bluuebunny/crossref_metadata_2025_split huggingface dataset:
MODIFIED LOW-DENSITY LIPOPROT EINS IN DI ABETES MELLITUS TYPE 2
Authors: Drapkina O. M. , Gegenava В. B. 
Published: July 2018

Objective:to compare the level of modified low-density lipoproteins (mLDL) in patients with diabetes mellitus type 2 (DM2) and without DM2; to identify the factors affecting mLDL сontent.Materials and methods.The study involved 64 patients; they were divided into 2 groups. The main group included 32 patients with DM2 (15 men and 17 women, median age – 65 years), the control group 2 included 32 patients without DM2 (15 men and 17 women, median age – 60.5 years). All patients (100 %) had arterial hypertension. Both groups were generally comparable in the main clinical and laboratory characteristics. Mann–Whitney test, Spearman correlation coefficient were used for statistical data processing.Results. In patients with DM2 mLDL level was significantly higher (р <0.001) and correlated with blood glucose concentration (p = 0.021), glycated hemoglobin values (p <0.001) and body-weight index (p = 0.007). In patients without DM2 mLDL level correlated with bodyweight index (p <0.001). No correlation between mLDL level and standard LDL content was found in patients with DM2 and in patients without DM2 (p = 0.714 and p = 0.758 respectively).Conclusion.DM2 is significantly associated with an increased mLDL level that is affected by parameters of carbohydrate metabolism and body-weight index. In persons without hyperlipidemia mLDL level increases in case of hyperglycemia.
CORRELATION BETWEEN VAS OPRESSIN CONCENTRATION AND CHRONIC HEART FAILURE SEVE RITY: CHARAC TERISTICS OF PA TIENTS WITH TERMINAL AND DECOMPE NSA TED HEART FAILURE
Authors: Trofimov E. S. , Poskrebysheva A. S. , Shostak N. А. 
Published: July 2018

Objective: to evaluate vasopressin (VP) concentration in patients with varying severity of chronic heart failure (CHF), intensity of clinical symptoms, and decreased level of left ventricular ejection fraction (LVEF). Materials and methods. In total, 120 patients (44 males, 76 females) with CHF of varying genesis (mean age 72.12 ± 10.18 years) and 30 clinically healthy individuals (18 males, 12 females) as a control group (mean age 33.4 ± 6.23 years) were examined. All patients underwent comprehensive clinical and instrumental examination in accordance with the standards for patients with CHF. The VP level was determined using ELISA. Statistical analysis was performed using the IBM SPSS Statistics v. 23 software.Results. The patients with CHF had significantly higher blood VP levels compared to the control group (72.91 ± 53.9 pg/ml versus 6.6 ± 3.2 pg/ml respectively; p <0.01). At the same time, patients with stage III CHF had significantly lower VP levels than patients with stages IIВ and IIА (35.61 ± 21.53 pg/ml versus 71.67 ± 48.31 pg/ml and 86.73 ± 59.78 pg/ml respectively; p<0.01). A similar picture was observed for the functional classes (FC). For instance, for CHF FC II and III, the VP level was 91.93 ± 67.13 pg/ml and 77.95 ± 54.01 pg/ml respectively, while for FC IV it decreased to 50.49 ± 28.18 pg/ml (p <0.01). The VP concentration in patients who subsequently perished was significantly lower than in patients who survived (48.79 ± 26.30 pg/ml versus 79.72 ± 57.73 pg/ml; p = 0.012). Moreover, in patients with LVEF <50 %, the VP level was significantly lower than in patients with LVEF >50 % (59.43 ± 42.51 pg/ml versus 86.43 ± 62.46 pg/ml respectively; p <0.05).Conclusion. The observed significant differences in VP in patients with stage III and IV CFH can indicate depletion of neurohumoral mediators in this patient category. However, a correlation between the VP level and the level of LVEF decrease can indicate a significant difference in the role of VP in CHF pathogenesis in patients with preserved and decreased LVEF. This observation requires further research.
SYSTEMIC VASCULITIS WITH LESION OF LARGE VESSELS AS A CAUSE OF ART ERIAL HYPERT ENSION IN A PATIENT OF YOUNG AGE
Authors: Andriyashkina D. Yu. , Demidova N. A. , Shostak N. А. , Somov D. A. , Laperishvili М. A. 
Published: July 2018

Objective:to analyze and present a clinical case of late diagnosis of Takayasu’s arteritis in a young female patient with long-term arterial hypertension.Materials and methods.The female patient G., born in 1989, had noted elevated arterial pressure (AP) of 150/90 mm Hg since she was 14. At 21 the following diagnosis was stated: Fibro-muscular dysplasia, stenosis of the left renal artery. Stenosis of the celiac trunk. Aneurisms of the branches of the superior mesenteric artery; prosthesis of the left renal artery was performed. Since the beginning of 2016, the patient has noted elevated AP of 200/110 mm Hg despite continuing hypotensive therapy. Diagnosis of Nonspecific aortoarteritis was proposed in May of 2017. Methylprednisolone therapy was administered: 250 mg No. 2 intravenously, Prednisolone: 25 mg a day orally. Due to signs of decreased blood flow to the left kidney, in August of 2017 extracorporeal repeat prosthesis of the left renal artery, bypass of the right middle renal artery with reversed autovein were performed.Results.During examination in October of 2017, the patient complained of weakness, frequent elevated AP of 200/110 mm Hg. In blood test: hemoglobin 106 g/l, erythrocyte sedimentation rate 38 mm/h, C-reactive protein 25 mg/l. A heterozygous mutation in the methylenetetrahydropholate reductase, a heterozygous mutation in the factor V gene (G1691A) were identified. Homocysteine level was normal, infection and oncological pathology were excluded. The following diagnosis was made: Takayasu»s arteritis type IV affecting the aorta and its branches, moderate activity. Occlusion of the celiac trunk. Aneurisms of the branches of the superior mesenteric artery. Critical stenosis of the left renal artery. Thrombosis of the aorto-renal prosthesis. Hypoplasia of the left kidney. Prednisolone 50 mg a day, metoprolol 50 mg a day, valsartan 160 mg a day, acetylsalicylic acid 100 mg a day were prescribed.Conclusion.The presented clinical observation shows the importance of comprehensive examination of young patients complaining of elevated AP for many years. Due to untimely diagnosis and absence of pathogenetic therapy, the patient suffered negative consequences of surgical treatment.
SELECTIVE INHIBITION OF KRAS SIGNALING BY COMBINATION OF LOW DOSE RAPAMYCIN AND PACLITAXEL IN VIVO
Authors: Yurova M. N. , Safina D. R. , Mizgirev I. V. 
Published: July 2018

Background.Therapy with compounds potentially capable to block KRAS oncogene signaling pathway is perspective direction in modern oncopharmacology. The aim of current study was to investigate effects of the combined treatment with rapamycin (RAP) and paclitaxel (PAC) in transgenic zebrafish (Danio rerio) with constant expression of mutant KRASV12 oncogene conjugated to green fluorescent protein (GFP) in epidermal cells. This strain has a modified phenotype due to epidermal hyperplasia and expression of GFP reporter at skin of embryos and adult fish.Materials and methods.Fish embryos 6 hpf were exposed to 0.1 % DMSO solution (control) and various doses of the drugs or combinations thereof. GFP expression in epidermal cells was morphometrically measured at 72 hpf.Results.Dose-related decrease in phenotypic changes up to complete epidermal normalization under RAP 50–400 nM treatment was observed. Treatment with nontoxic for embryos doses of PAC 50–250 nM increased fluorescence level in a dose-dependent manner, indicating an activation of KRAS signaling. Using of lower doses of RAP (10 and 25 nM) or PAC (10 nM) had no statistically significant effect on expression of transformed phenotype. Whereas combined treatment (RAP 10–25 nM and PAC 10–50 nM) dramatically decreased level of epidermal fluorescence and completely normalized phenotype of transgenic fish.Conclusions.Thus, mutual potentiating effect of RAP and PAC in low doses which leads to selective inhibition of the KRAS signaling pathway was revealed, indicating the prospect of further studies of these drugs combination for targeted cancer therapy.
ÖĞRETMENLERİN MESLEĞE YÖNELİK DAVRANIŞ VE YAŞANTI MODELLERİNİN BELİRLENMESİ: BARTIN İLİ ÖRNEĞİ
Authors: Karakaş Ayhan , Kıngır Said , Kiremitçi Olcay 
Published: July 2018

Bu çalışmanın amacı öğretmenlerin mesleklerine yönelik
davranış modellerinin ve yaşantı modellerinin belirlenmesi ve öğretmenlerin
mesleğe yönelik davranış ve yaşantı modellerinin çeşitli değişkenlere göre
farklılık gösterip göstermediğini saptamaktır. Çalışmada MEDYAM (Mesleğe
Yönelik Davranış ve Yaşantı Modelleri) ölçeği kullanılmıştır. Çalışma Bartın
ilindeki merkezi ilköğretim ve ortaöğretim kurumlarında çalışan 279 öğretmen
üzerinde 2015 Aralık ayında gerçekleştirilmiştir. Çalışmada elde edilen
verilerin analizinde frekans analizi, t testi ve ANOVA yapılmıştır. Elde edilen
sonuçlara göre öğretmenlerin, %39.4’ünün sakınmacı grupta yer aldığı,
%11.8’inin ise tükenmiş olarak nitelendirilen ve sağlık açısından en kötü grup
olan grupta yer aldığı görülmektedir. En sağlıklı grubun oranı ise %32.6’dır.
Çalışmada yapılan analizler sonrası, öğretmenlerin mesleğe yönelik davranış alt
boyutlarından elde edilen ortalama puanların, cinsiyet değişkenine göre
mükemmeliyetçilik çabası, yaşam doyumu ve sosyal destek yaşantısı boyutlarında
anlamlı bir farklılık görülmektedir. Öğretmenlerin medeni durumlarına göre, işin öznel önemi, mesleki hırs, başarma
eğilimi ve yaşam doyumu alt boyutlarında anlamlı farklılık, yaşlarına göre işin öznel önemi, mesleki
doyum ve sosyal destek yaşantısı alt boyutlarında anlamlı farklılık
bulunmaktadır. Hizmet yılı değişkenine göre, pes etme eğilimi, sosyal destek
yaşantısı alt boyutlarında deneyimsiz öğretmenlerin puanlarının daha yüksek
olması buna karşın işin öznel önemi, başarma eğilimi, alt boyutunda ise
deneyimli öğretmenlerin daha fazla puan alması istatistiki olarak
farklılaşmaktadır.
Homocysteine remethylation pathway in neonates with congenital heart disease and neural tube defects
Authors: Surmiak Piotr , Baumert Małgorzata , Walencka Zofia , Paprotny Magdalena , Witek Andrzej 
Published: July 2018

WstępEtiologia wrodzonych wad serca (WWS) oraz wad cewy nerwowej (WCN) jest niewyjaśniona, wykazano jednak związek między stężeniem homocysteiny oraz kwasu foliowego a występowaniem wrodzonych anomalii.
Celem pracy była ocena stężenia biochemicznych markerów szlaku metabolizmu homocysteiny u noworodków z WWS oraz WCN i ich matek.Materiał i metodyBadaniem objęto 47 par – matka i jej noworodek urodzony z WWS (n = 29) i WCN (n = 18). Grupę kontrolną (GK) stanowiły 54 pary matek i ich zdrowe dzieci. Próbki krwi matki i krwi pępowinowej pobierano w celu oznaczenia stężenia tHcy, kwasu foliowego i witaminy B12.WynikiStężenie tHcy u noworodków z WWS było znamiennie wyższe niż u ich matek oraz u dzieci z WCN. Stężenie tHcy u noworodków z WCN było znamiennie wyższe niż w grupie kontrolnej. Stężenia witaminy B12 były podobne u wszystkich badanych noworodków w porównaniu z wartościami stwierdzonymi u ich matek. U noworodków z WCN i WWS stężenie kwasu foliowego w krwi pępowinowej było znamiennie niższe niż u dzieci z grupy kontrolnej.WnioskiZaobserwowane różnice w stężeniu homocysteiny i kwasu foliowego między noworodkami z wrodzonymi wadami serca i wadami cewy nerwowej sugerują obecność dodatkowych czynników zaburzających szlaki metaboliczne homocysteiny u tych dzieci.
LITERASI INFORMASI SEJAK DINI: PENGETAHUAN BARU BAGI ANAK USIA DINI
Authors: Riady Yasir 
Published: July 2018

The golden age of children aged 0 to 8 years is a phase in which children begin to know the world and will determine how it will grow, develop, live and move on through life. This step of life will take place only once in human life, as well as the growth rate of rapid growth to reach about 50 % the capacity of the human intellect has occurred when the age of 4 years, 80 % occurred when the age of 8, and 100 % when the child reaches the age of 8-18 years, means such a vulnerable age in the elementary age child development. One of the things that must be understood for the development of early childhood literacy is the ability of information that must be developed early on, it can help children to have the skills and ability to identify, locate, evaluate, organize and effectively create new knowledge, use it and communicate it in a series of problem solving at hand. This paper describes the importance of information literacy as an initial stage for the child to progress in his new knowledge, the organization of early childhood education by looking at the quality and the added ability to make information literacy prior knowledge of the child so that the child develops to become intelligent, wise and noble.
Analysis on the Effect of Deposits and Financing on The Net Income (SHU) at KPN Al Ikhlas IAIN Batusangkar
Authors: Rizal R. , David D. , Fitri Sri Adella , Ramadanis R. 
Published: July 2018

<div class="page" title="Page 1"><div class="layoutArea"><div class="column"><p><span>Cooperative is an institution founded by and for the members with the purpose to prosper the members with maximum achievement of outcome. The phenomenon that happened in Sharia civil servant cooperative Al-Ikhlas in IAIN Batusangkar from year of 2015 until the closing book in 2016, shows that </span><span>member deposits and financing toward members has </span><span>increased. Meanwhile, the net income is decreased. This phenomenon is interesting to investigate because </span><span>it seems like the increasing of deposits and financing do not influence the net income. Consequently, This </span><span>research aims to analysis the effect of deposit, such </span><span>as special obligatory deposit, financing deposit and financing simultaneously and partially towards net </span><span>income (SHU) at sharia civil servant cooperative </span><span>(KPN) Al Ikhlas IAIN Batusangkar. This is a field research with quantitative approach during the </span><span>year of 2015 and 2016 as the secondary data. The R</span>esult of this research shows that partially, merely financing that has effect towards net income (SHU) with significance level accost 6% that is 0.059 on wald value in the amount of 3,561.While basic contribution, obligatory deposit, special obligatory deposit, financing deposit have no significant effect on net income (SHU). Furhtermore, the amount of basic contribution effect, obligatory deposit effect, special obligatory deposit effect, financing deposit and financing simultaneously on net income (SHU) is 57.2%, while the remaining 42.8% is influenced by other factors that not examined in this research. It is suggested to the management of this sharia cooperative to find out another halal finance to increase financing so it can increase net income such as increasing member participation by gaining the amount of deposits. </p></div></div></div>
Brief Standing Desk Intervention to Reduce Sedentary Behavior at a Physical Activity Conference in 2016
Authors: Wilson Jason J. , Adlakha Deepti , Cunningham Conor , Best Paul , Cardwell Chris R. , Stephenson Aoife , Murphy Marie H. , Tully Mark A. 
Published: July 2018

Objectives. To examine the impact of environmental restructuring on attendees at a physical activity conference when provided with standing tables and given point-of-decision prompts (PODPs; e.g., health messages). Methods. This randomized controlled trial took place at the Health-Enhancing Physical Activity Europe 2016 conference in Belfast, United Kingdom, September 2016. We randomly allocated 14 oral sessions to either the intervention group (standing tables + PODPs; n = 7) or the control group (PODPs only; n = 7). Conference volunteers discreetly recorded the number of attendees standing and sitting and estimated the number of women and attendees aged 40 years or older. Results. There was a significant difference (P = .04) in the proportion of attendees standing during the intervention (mean = 16.8%; SD = 9.5%) than during control sessions (mean = 6.0%; SD = 5.8%). There was no differential response between gender and age groups in the proportion standing during intervention sessions (P > .05). Conclusions. Providing standing tables may be a feasible and effective strategy to reduce sitting at physical activity conferences.
Open Defecation Sites, Unmet Sanitation Needs, and Potential Sanitary Risks in Atlanta, Georgia, 2017–2018
Authors: Capone Drew , Ferguson Anna , Gribble Matthew O. , Brown Joe 
Published: July 2018

Objectives. To survey the spatial distribution and enteric pathogen profile of discarded human feces in the city of Atlanta, Georgia. Methods. After defining priority search areas in central Atlanta, we conducted 5 searches of open defecation sites totaling 15 hours during the period from October 2017 to January 2018. We collected fresh stools for analysis via multiplex reverse-transcription polymerase chain reaction to identify presence of 15 common parasitic, bacterial, and viral enteric pathogens. Results. We identified and mapped 39 open defecation sites containing 118 presumptive human stools; 23% of the 26 collected fresh stools tested positive for 1 or more pathogens. An estimated 12% of stools were positive for enterotoxigenic Escherichia coli, 7.7% for Giardia spp., 3.8% for norovirus, and 3.8% for Salmonella spp. The majority (92%) of identified open defecation sites were within 400 meters of a shelter or soup kitchen. Conclusions. Though this study was constrained by a small sample size, results suggest that open defecation in Atlanta is common and may pose risks to public health. Public Health Implications. Open defecation may pose health risks to people experiencing homelessness and the general public.
Human Papillomavirus Vaccine Initiation for Adolescents Following Rhode Island’s School-Entry Requirement, 2010–2016
Authors: Thompson Erika L. , Livingston Melvin D. , Daley Ellen M. , Zimet Gregory D. 
Published: July 2018

Objectives. To assess changes in human papillomavirus (HPV) vaccine initiation for adolescent girls and boys in Rhode Island compared with all other states. Methods. We estimated the gender-specific effects of Rhode Island’s school-entry HPV vaccination policy on self-reported HPV vaccination initiation by using a difference-in-differences design with the National Immunization Survey–Teen from 2010 through 2016. Results. Compared with boys in other states, boys in Rhode Island increased their HPV vaccine initiation rate by 11% (b = 0.11; 95% confidence interval [CI] = 0.05, 0.18) after enactment of the requirement. No difference was seen in the probability of HPV vaccine initiation among girls in Rhode Island compared with girls in the multistate control (b = −0.01; 95% CI = −0.08, 0.05). Conclusions. Our analysis identified an 11% increase in HPV vaccine initiation rate among boys in Rhode Island after the school-entry requirement was enacted, whereas no significant change was observed for girls. Public Health Implications. Given suboptimal vaccine uptake rates in the United States, continued pursuit of state-level public policy to improve HPV vaccination is needed. School-entry requirements for HPV vaccination may be a strategy for closing the gap in HPV vaccine uptake for boys and girls.
Clinical Evaluation of Synovial Alpha Defensin and Synovial C-Reactive Protein in the Diagnosis of Periprosthetic Joint Infection
Authors: Stone William Z. , Gray Chancellor F. , Parvataneni Hari K. , Al-Rashid Mamun , Vlasak Richard G. , Horodyski MaryBeth , Prieto Hernan A. 
Published: July 2018

Background:
Diagnosing periprosthetic joint infection after total joint arthroplasty is often challenging. The alpha defensin test has been recently reported as a promising diagnostic test for periprosthetic joint infection. The goal of this study was to determine the diagnostic accuracy of alpha defensin testing.

Methods:
One hundred and eighty-three synovial alpha defensin and synovial fluid C-reactive protein (CRP) tests performed in 183 patients undergoing evaluation for periprosthetic joint infection were reviewed. Results were compared with the Musculoskeletal Infection Society (MSIS) criteria for periprosthetic joint infection.

Results:
Alpha defensin tests were performed prior to surgical treatment for infection, and 37 of these patients who had these tests were diagnosed by MSIS criteria as having infections. Among this group, the alpha defensin test had a sensitivity of 81.1% (95% confidence interval [CI], 64.8% to 92.0%) and a specificity of 95.9% (95% CI, 91.3% to 98.5%). There were 6 false-positive results, 4 of which were associated with metallosis. There were 7 false negatives, all of which were associated with either draining sinuses (n = 3) or low-virulence organisms (n = 4). A combined analysis of alpha defensin and synovial fluid CRP tests was performed in which a positive result was represented by a positive alpha defensin test and a positive synovial fluid CRP test (n = 28). Among this group, the sensitivity was calculated to be 73.0% (95% CI, 55.9% to 86.2%) and the specificity was calculated to be 99.3% (95% CI, 96.2% to 99.9%). An additional combined analysis was performed where a positive result was represented by a positive alpha defensin test or positive synovial fluid CRP test (n = 64). Among this group, the sensitivity was calculated to be 91.9% (95% CI, 78.1% to 98.3%) and the specificity was calculated to be 79.5% (95% CI, 72.0% to 85.7%).

Conclusions:
Alpha defensin in combination with synovial fluid CRP demonstrates very high sensitivity for diagnosing periprosthetic joint infection, but may yield false-positive results in the presence of metallosis or false-negative results in the presence of low-virulence organisms. When both alpha defensin and synovial fluid CRP tests are positive, there is a very high specificity for diagnosing periprosthetic joint infection.

Level of Evidence:
Diagnostic Level III. See Instructions for Authors for a complete description of levels of evidence.