bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ergenlerin Değer Yönelimleri ve Değer Yönelimlerinin İnternet Bağımlılığıyla İlişkisinin İncelenmesi
Authors: DOĞAN Mebrure 
Published: December 2018

Araştırmanın amacı ergenlerin
hayatlarında hangi değerlerin etkisini daha çok hissettiklerini, çeşitli
değişkenlerin değer tercihlerinde değişikliğe yol açıp açmadığını ortaya
koymaktır. Ergenlerin internet bağımlılığı düzeyleri ile değer yönelimleri arasındaki
ilişkileri incelemek araştırmanın diğer bir amacını oluşturmaktadır. Ülkemizde
ergenlerin değer yönelimlerinin internet bağımlılığı ile ilişkisini ele alan
bir çalışmaya rastlanmamıştır. Hangi değerlerin ergenler üzerinde daha etkili
olduğunu ve bunların internet bağımlılığı ile ilişkisini incelenmesinin
internet bağımlılığını önleme çalışmalarına yardımcı olacağı düşünülmektedir.
Afyonkarahisar ilinde bulunan beş farklı lisede öğrenim görmekte olan 134’ü kız
(% 48,6), 142’si erkek (% 51,4) olmak üzere 276 lise öğrencisinin katıldığı
çalışmada veriler, “Schwartz Değerler Ölçeği “ ve “Young İnternet Bağımlılığı
Testi Kısa Formu” ile toplanmıştır.
T-testi, One way ANOVA, Pearson Momentler Çarpım Korelasyon tekniğinin
kullanıldığı araştırmada elde edilen bulgulara göre cinsiyet açısından erkek
öğrenciler “güç, hazcılık ve uyarılım” değerlerini, kız öğrenciler ise
“evrensellik, uyma” değerlerini daha
fazla önemsemektedirler. Örneklem grubunun değer sıralaması “dindarlık,
iyilikseverlik, güvenlik, öz-yönelim, evrensellik, uyma, başarı, geleneksellik,
uyarılım, güç, hazcılık” şeklinde belirlenmiştir. Araştırmada internet
bağımlılığı ile “güç, hazcılık, uyarılım” değerleri arasında pozitif;
“evrensellik, iyilikseverlik, geleneksellik, uyma ve dindarlık” değerleri
arasında ise negatif yönlü anlamlı ilişkiler tespit edilmiştir.
UM ESTUDO SOBRE A PERSONALIZAÇÃO DO ENSINO COM A COLABORAÇÃO DE RECURSOS AUDIOVISUAIS EM AMBIENTES INTERATIVOS PARA A APRENDIZAGEM DA DISCIPLINA DE HISTÓRIA – RESULTADOS PRELIMINARES
Authors: Marchi Késsia Rita da Costa , Neto Alexandre Amaury de Mello , Andrade Lucas de Melo 
Published: December 2018

Este artigo descreve um estudo sobre a personalização do ensino e a colaboração das TIC’s (Tecnologias de Informação e Comunicação) para a aprendizagem da disciplina de História no Ensino Médio. Para esta personalização foi considerado a Educação Híbrida e sua relação com a personalização do ensino, na qual, refere-se a uma combinação entre o modelo convencional de ensino e os recursos (impressos ou digitais) que possibilitem oportunidades para o aluno aprender dentro de seu ritmo individual de aprendizagem, desenvolvendo, inclusive, habilidades autônomas. Para tanto, é discutido neste trabalho o modelo tradicional de ensino de História e os novos desafios colocados pela era digital ao processo de ensino e aprendizagem, desafios estes, que têm se mostrado como uma tendência de evolução do processo educacional, demandando soluções que possibilitem colaborar no desenvolvimento de conteúdos interativos. Também é apresentado neste trabalho uma análise de alguns dados que foram obtidos por meio de aplicação de questionários, sendo que no decorrer desta análise buscou-se compreender de que forma os professores entrevistados relacionavam-se com os recursos tecnológicos utilizados em suas aulas e quais possíveis problemas encontrados na produção de materiais didáticos para personalizarem suas práticas educacionais. Após esta análise, este trabalho apresenta uma proposta de construção de ferramenta que objetiva auxiliar esses professores a inserirem, em seus processos de ensino e aprendizagem o ensino híbrido, mediado por TIC´s.
ÍNDICE DE SALUBRIDADE AMBIENTAL DO MUNICÍPIO DE UMUARAMA/PR COM BASE NOS DADOS DO ANO DE 2016
Authors: Lupepsa Vanda Zago , Hoffmann César Augusto , Santana Junior Jorgelino Pedro de , Barbado Norma 
Published: December 2018

Resumo: Conhecer o nível de qualidade de vida em um Município é primordial para o desenvolvimento de determinada localidade, pois com a ciência desta informação, a cidade se torna mais atrativa a novos investimentos, sendo que as cidades têm buscado ampliar a qualidade e oferta de serviços e equipamentos públicos urbanos a fim de elevar a salubridade ambiental. Atualmente, a busca por qualidade de vida tem peso importante na decisão das pessoas, na escolha de onde viver. Os dados considerados para esta adaptação do ISA, são voltados para a qualidade social, econômica e ambiental, fomentando o tripé da sustentabilidade, levando em conta em um de seus sub indicadores também a qualidade urbana. Foram considerados, para esta análise, os seguintes indicadores: Indicador de Abastecimento de Água (IAA) com peso 0,20; Indicador de Esgoto Sanitário (IES) com peso 0,20; Indicador de Resíduos Sólidos (IRS) com peso 0,20; Indicador de Drenagem Urbana (IDU) com peso 0,10; Indicador de Qualidade Urbana (IQU) com peso 0,15; Indicador socioeconômico (ISE) com peso 0,15. De acordo com o levantamento de dados realizado, o índice de Salubridade Ambiental (ISA) do Município de Umuarama/PR, para o ano de 2016, alcançou 0,9207 sendo que o índice máximo de avaliação do ISA é de 1,0. Assim sendo, a cidade de Umuarama é considerada salubre frente aos parâmetros de avaliação adotados.
3D Printing Technology in Drug Delivery: Recent Progress and Application
Authors: Kotta Sabna , Nair Anroop , Alsabeelah Nimer 
Published: December 2018

Background:
3D printing technology is a new chapter in pharmaceutical manufacturing and has gained
vast interest in the recent past as it offers significant advantages over traditional pharmaceutical processes. Advances
in technologies can lead to the design of suitable 3D printing device capable of producing formulations
with intended drug release.

Methods:
This review summarizes the applications of 3D printing technology in various drug delivery systems.
The applications are well arranged in different sections like uses in personalized drug dosing, complex drugrelease
profiles, personalized topical treatment devices, novel dosage forms and drug delivery devices and 3D
printed polypills.

Results:
This niche technology seems to be a transformative tool with more flexibility in pharmaceutical manufacturing.
Typically, 3D printing is a layer-by-layer process having the ability to fabricate 3D formulations by
depositing the product components by digital control. This additive manufacturing process can provide tailored
and individualized dosing for treatment of patients different backgrounds with varied customs and metabolism
pattern. In addition, this printing technology has the capacity for dispensing low volumes with accuracy along
with accurate spatial control for customized drug delivery. After the FDA approval of first 3D printed tablet Spritam,
the 3D printing technology is extensively explored in the arena of drug delivery.

Conclusion:
There is enormous scope for this promising technology in designing various delivery systems and
provides customized patient-compatible formulations with polypills. The future of this technology will rely on its
prospective to provide 3D printing systems capable of manufacturing personalized doses. In nutshell, the 3D
approach is likely to revolutionize drug delivery systems to a new level, though need time to evolve.
M918: A Novel Cell Penetrating Peptide for Effective Delivery of HIV-1 Nef and Hsp20-Nef Proteins into Eukaryotic Cell Lines
Authors: Rostami Bahareh , Irani Shiva , Bolhassani Azam , Cohan Reza Ahangari 
Published: December 2018

Background:
HIV-1 Nef protein is a possible attractive target in the development of
therapeutic HIV vaccines including protein-based vaccines. The most important disadvantage of
protein-based vaccines is their low immunogenicity which can be improved by heat shock proteins
(Hsps) as an immunomodulator, and cell-penetrating peptides (CPPs) as a carrier.

Methods:
In this study, the HIV-1 Nef and Hsp20-Nef proteins were generated in E.coli expression
system for delivery into the HEK-293T mammalian cell line using a novel cell-penetrating peptide,
M918, in a non-covalent fashion. The size, zeta potential and morphology of the peptide/protein
complexes were studied by scanning electron microscopy (SEM) and Zeta sizer. The efficiency of
Nef and Hsp20-Nef transfection using M918 was evaluated by western blotting in HEK-293T cell
line.

Results:
The SEM data confirmed the formation of discrete nanoparticles with a diameter of approximately
200-250 nm and 50-80 nm for M918/Nef and M918/Hsp20-Nef, respectively. The
dominant band of ~ 27 kDa and ~ 47 kDa was detected in the transfected cells with the Nef/ M918
and Hsp20-Nef/ M918 nanoparticles at a molar ratio of 1:20 using anti-HIV-1 Nef monoclonal antibody.
These bands were not detected in the un-transfected and transfected cells with Nef or Hsp20-
Nef protein alone indicating that M918 could increase the penetration of Nef and Hsp20-Nef proteins
into the cells.

Conclusion:
These data suggest that M918 CPP can be used to enter HIV-1 Nef and Hsp20-Nef
proteins inside mammalian cells efficiently as a promising approach in HIV-1 vaccine development.
Metal and Non-Metal Catalysts in the Synthesis of Five-Membered S-Heterocycles
Authors: Kaur Navjeet 
Published: December 2018

Background:A wide variety of biological activities are exhibited by N, O and S containing heterocycles and recently, many reports appeared for the synthesis of these heterocycles. The synthesis of heterocycles with the help of metal and non-metal catalyst has become a highly rewarding and important method in organic synthesis. This review article concentrated on the synthesis of S-heterocylces in the presence of metal and non-metal catalyst. The synthesis of five-membered S-heterocycles is described here.Objective:There is a need for the development of rapid, efficient and versatile strategy for the synthesis of heterocyclic rings. Metal, non-metal and organocatalysis involving methods have gained prominence because traditional conditions have disadvantages such as long reaction times, harsh conditions and limited substrate scope.Conclusion:The metal-, non-metal-, and organocatalyst assisted organic synthesis is a highly dynamic research field. For ßthe chemoselective and efficient synthesis of heterocyclic molecules, this protocol has emerged as a powerful route. Various methodologies in the past few years have been pointed out to pursue more sustainable, efficient and environmentally benign procedures and products. Among these processes, the development of new protocols (catalysis), which avoided the use of toxic reagents, are the focus of intense research.
Trends in the Analysis of Biopharmaceuticals by HPLC
Authors: Tartaglia Angela , Locatelli Marcello , Samanidou Victoria 
Published: December 2018

Background:
Biopharmaceuticals are biological drugs consisting of a complex compound
that can be produced by a living organism or derive from it. Biopharmaceuticals are very complicated
compounds from structural point of view and for this reason, they cannot be fully characterized in
terms of their structure with current analytical methods as it happens instead of low molecular weight
chemicals drugs.

Introduction:
The regulatory guidelines require the characterization of the primary or higher sequence
of these molecules and the characterization of any post-translational modifications. The use
of biopharmaceuticals has really grown in the last few years: in 2016, the number of biopharmaceuticals
approved by the Food and Drug Administration (FDA) and European Medicines Agency (EMA)
for use in humans’ diseases was 1357. From 2013 to 2016, 73 of these compounds were approved for
the treatment of cancer, inflammation, immune disorders, infections, anemia and cardiovascular diseases.

Aim/Conclusion:
The aim of the present review is to provide an overview of recent approaches for
the characterization of biopharmaceutical products in HPLC that have been presented in the literature
in the last years.
Опыт применения различных методик проведения комбинированной спинально-эпидуральной анестезии при реконструктивных операциях на артериях нижних конечностей
Authors: Chebanov K.O. , Klygunenko O.M. , Novikov S.P. , Ploschenko Yu.A. , Dubova V.M. , Baida Yu.B. , Lapkin I.V. 
Published: December 2018

Актуальность. За последние годы регионарные методы обезболивания шагнули на несколько ступеней вверх. Помимо появления новых препаратов для введения в эпидуральное и субарахноидальное пространство, на сегодняшний день существует целый ряд комбинированных методов регионарной анестезии и анальгезии, которые включают все преимущества используемых методов одновременно. В нашей клинике на базе городского сосудистого центра реконструктивные операции на артериях нижних конечностей проводятся преимущественно в условиях комбинированной спинально-эпидуральной анестезии (КСЭА), которая может технически выполняться по одно- и двухуровневой методике. Цель исследования: сравнить эффективность анестезии и послеоперационной анальгезии при применении одно- и двухуровневой комбинированной спинально-эпидуральной анестезии. Материалы и методы. Проанализированы 2 группы пациентов по 39 человек, которым было показано оперативное вмешательство на артериях нижних конечностей. В первой группе проводилась одноуровневая КСЭА, во второй — двухуровневая КСЭА. Премедикация в обеих группах за 40 минут до операции включала инфулган 100 мл внутривенно, дексалгин 2,0 внутримышечно, осетрон 4 мг внутривенно. Вопрос о преинфузии решался индивидуально. Оценку результатов мы осуществляли по признакам эффективности интраоперационной анестезии, времени разрешения двигательного блока, эффективности послеоперационной анальгезии по визуально-ассоциативной шкале, а также адекватности перфузии. Результаты. Интраоперационно в группе одноуровневой КСЭА 8 (20,5 %) пациентам понадобилось дополнительное введение анестетика в эпидуральное пространство с целью анестезии, во второй — 10 пациентам (26 %), однако данные показатели не достигали степени статистической достоверности (р < 0,05) и данная погрешность не является значимой. Полное разрешение двигательного блока в послеоперационном периоде в обеих группах наступало через 4,0 ± 0,5 часа. Дальнейшее обезболивание в обеих группах производилось через эпидуральный катетер с интервалом каждые 4 часа и не достигало по визуально-ассоциативной шкале более 4 баллов, соответственно, не требовалось дополнительного назначения наркотических анальгетиков как в первой, так и во второй группе. Выводы. Техника одно- и двухуровневой КСЭА позволяет в равной степени достичь должного эффекта интраоперационной анестезии, своевременного разрешения двигательного блока, а также всех положительных эффектов продленной эпидуральной анальгезии в послеоперационном периоде.
SISTEM INFORMASI APLIKASI PENGELOLAAN TRANSAKSI KEUANGAN DAN PENDATAAN KONSUMEN PADA CV. PUPLAS
Authors: Loveri Tomi Tm 
Published: December 2018

<em>The author conducted research on Cv. Puplas s, aims to know about financial management and data collection of consumers in Cv. Puplas. Transaction management and report creation that is still manual and do not have a database, so often the occurrence of errors in the processing of financial transactions. Likewise, when the consumer data processing and reporting process given to the leadership takes a long time and less efficient, because the data is still in the form of archives. To overcome this problem, the writer tries to design a system that can solve the problem. This research is done using field research method with direct observation and interview, then in Library Research for Literature study and laboratory research to design Information System using Web Programing CodeIgniter and SQLyog as database manager</em>
OPTIMALISASI JALUR EVAKUASI TSUNAMI MENGGUNAKAN SISTEM INFORMASI GEOGRAFIS DI KOTA PADANG BERBASIS WEB
Authors: Yanto Heri 
Published: December 2018

<p>Sistem Informasi Geografi adalah suatu sistem informasi yang digunakan untuk memasukkan, menyimpan, memanggil kembali, mengolah, menganalisa dan menghasilkan data bereferensi geografis atau geospatial, untuk mendukung pengambilan keputusan dalam suatu perencanaan. Pemberian pengetahuan ini dilakukan dengan memanfaatkan teknologi dan ilmu pegetahuan yang berkembang saat ini yaitu sistem Informasi Geografis. Sistem ini akan dapat memberikan suatu informasi yang berguna bagi user dengan pemanfaatan pemetaan <em>GIS</em>. Sistem Informasi Geografi ini dibangun untuk pemilihan jalur evakuasi yang paling optimal sedangkan metode yang digunakan untuk menggambarkan pemodelannya yaitu menggunakan UML. Sistem ini penulis rancang dengan menggunakan Mapserver dan merupakan berbasis <em>web</em>.</p>
Predicting Sense of Presence and Sense of Community in Immersive Online Learning Environments
Authors: McClannon Terry W. , Cheney Amy , Bolt Les , Terry Krista 
Published: December 2018

This study is based on survey research conducted between 2010 and 2017, involving 1053 graduate students using immersive online learning environments for their coursework. Investigators used course structural factors and student engagement factors to predict students’ perceptions of community and presence in the online immersive space. Utilizing the Sense of Community II index (SCI-2) and the Community of Inquiry survey (COI) median scores as cut scores for predicted outcomes, researchers demonstrated that purely online environments which encouraged student engagement in the online immersive space can enhance sense of presence and sense of community. In addition, students in graduate programs that used online immersive delivery methods longer developed a stronger sense of community. Both dependent measures proved to have stable subscale structures for this inquiry based on a cursory confirmatory factor analysis
DIGGING DEEPER INTO THE DATA: THE ROLE OF GATEWAY COURSES IN ONLINE STUDENT RETENTION
Authors: Swan Karen , Bloemer William , Bogle Leonard , Day Scott 
Published: December 2018

Improvement in undergraduate retention and progression is a priority at many US postsecondary institutions and there seems to be a growing movement to address it by identifying gateway courses (foundational courses in which a large number of students fail or withdraw) and concentrating on “fixing” them. This paper argues that may not be the best use of limited resources. No matter what we do, there will always be courses with high DFW rates simply because of the nature of their content and the preparation of the students who must take them. Our research suggests that student type and academic stage affect student success and that gateway courses (courses which block student progression) can be found at all undergraduate levels. Specifically, we have found that one can use student type, academic stage, cumulative GPA, and prior withdrawals to predict success in undergraduate courses. Moreover, relating predictions to observed DFW rates can highlight courses exceeding expectations, and those which fall below them, to support a more nuanced understanding of where and what attention is needed. We illustrate the utility of such approach by examining issues surrounding success in online courses at our institution.
Synchronous and Asynchronous Discussions: Effects on Cooperation, Belonging, and Affect
Authors: Peterson Amy T , Beymer Patrick N. , Putnam Ralph T. 
Published: December 2018

Supporting productive peer-to-peer interaction is a central challenge in online courses. Although cooperative learning research provides robust evidence for the positive outcomes of face-to-face cooperative learning (Johnson & Johnson, 1989), online modes of cooperative learning have provided mixed results. This study examines the effects of synchronous versus asynchronous interaction on students’ sense of cooperation, belonging, and affect in online small-group discussions. Fifty-two undergraduate students were assigned to synchronous and asynchronous interaction conditions. The findings support prior research that asynchronous communication interferes with the relationship between cooperative goals and the outcomes of cooperation. Results inform theory and practice, by showing that asynchronous cooperative learning may not work as designed because the presence of cooperative goals do not predict cooperative outcomes.
Süt Sığırcılığı İşletmelerinde Üreticilerin Kooperatif Kanalıyla Süt Pazarlama Olasılığını Etkileyen Faktörler: Trakya Bölgesi Örneği
Authors: KOÇ Gökçe , UZMAY Ayşe 
Published: December 2018

Türkiye’de kalkınma ve tarım
politikalarının öncelikli hedeflerinden biri tarımsal üretimde örgütlenmenin
arttırılmasıdır, ancak, kooperatif bilinci, kültürü ve güçlü bir
kooperatifçilik yapılanması henüz oluşturulamamıştır. Tarımın en önemli alt
sektörlerinden biri olan süt ve süt ürünleri sektöründe de kooperatiflerin
payının son derece düşük olduğu dikkati çekmektedir. Kooperatifleşmenin
arttırılması, hayvancılığın ve özellikle süt sığırcılığının karşı karşıya
kaldığı sorunların çözümünde etkili bir yöntem ve önemli bir politika aracıdır.
Bu kapsamda, bu araştırmanın temel amaçları süt üretiminde stratejik öneme
sahip olan Trakya Bölgesi’nde küçük ve orta boy süt sığırcılığı işletmelerinde örgütlenmenin
durumunu ortaya koymak, üreticilerin sütlerini kooperatif aracılığıyla
pazarlama olasılığını etkileyen faktörleri belirlemek ve bölgede örgütlenmenin
geliştirilmesi için politika önerileri sunmaktır. Araştırmanın ana materyalini
bölgenin üç ilinde (Kırklareli, Tekirdağ ve Edirne) 108 üretici ile
gerçekleştirilen yüz yüze görüşmeler oluşturmaktadır. Üreticilerin sütlerini
kooperatif aracılığıyla pazarlama olasılığını etkileyen faktörlerin analizinde
lojistik regresyon modelinden yararlanılmıştır. Görüşülen üreticilerin %60.2’si
sütlerini kooperatif aracılığıyla pazarlamaktadır. Model sonuçlarına göre,
üreticinin eğitim seviyesi, çocukların süt sığırcılığında çalışması, üretimden
vazgeçme isteği ve satış fiyatı sütün kooperatif aracılığıyla pazarlanma
olasılığını etkilemektedir. Araştırma sonucunda, kooperatiflerin rekabet
gücünün arttırılması ve işleme tesislerini kurarak piyasada etkinliğinin sağlanmasının
gerekliliği vurgulanmıştır. Bu destekler, bölge üreticilerinin refahının
artması, katma değer ve istihdam yaratılması, ayrıca bölgede sektörün ülke
ekonomisi ve ihracatına katkısının arttırılması açısından önemlidir.
علم لغة المدونات والترجمة
Authors: Ibrahim Riyadh Khalil 
Published: December 2018

شهد القرن الواحد والعشرين تطورا تكنولوجيا وتنظيميا في الاقتصاد والمجتمع الدولي مما عكس أثرا كبيرا على الترجمة والدراسات الترجمة. تعد المدونة مجموعة لغوية طبيعية تعرض للقراءة على الحاسوب لاغراض التحليل اللغوي لنماذج لغوية متنوعة وهي الأساس لظهور علم لغة المدونات. لقد عمل علم لغة المدونات على تسهيل مهمة المترجمين في الاستفادة من كميات هائلة من المعلومات المخزونة في الحاسوب لغرض دراسة وترجمة اللغة الهدف . تهدف الدراسة الحالية الى تعريف طلبة الترجمة والمترجمين على طرق التطبيق العملي لمدونات الحاسوب لاستخدامها في مختلف حقول المعرفة. لقد أظهرت الدراسة أن علم لغة المدونات ذا أهمية بالغة في التوصيف الدقيق لنماذج مختلفة من اللغة حيث يوضح كيفية التفاعل بين المفردات والنحو وعلم لغة الدلالة لإنتاج الترجمة الملائمة. تضم مدونات الحاسوب نصوصا مكتوبة، شفوية، عامية، رسمية، روائية وغير روائية لمختلف المناطق السكانية وعلم جغرافية اللغة ومن هنا تبرز الحاجة لتكوين مدونات عربية وطنية للمؤلفين العرب لغرض المقارنة مع المدونات الاجنبية.