bluuebunny/crossref_metadata_2025_split huggingface dataset:
Wearable Technology in the Management of Chronic Diseases: A Growing Concern
Authors: Adepoju Victor Abiola , Jamil Safayet , Biswas Mohammad Shahangir , Chowdhury ABM Alauddin 
Published: December 2024

ABSTRACTWearable technology in the management of chronic diseases has emerged as a significant and growing concern in healthcare. These technologies, including smartwatches, fitness trackers, and other sensor‐based devices, offer continuous monitoring and real‐time data collection for individuals with chronic conditions. The data collected can include vital signs, activity levels, sleep patterns, and more, providing valuable insights into a patient's health. This trend is particularly relevant in the context of chronic diseases, such as diabetes, cardiovascular conditions, and respiratory disorders, where continuous monitoring is crucial for effective management. Wearable devices empower patients to actively participate in their healthcare by facilitating self‐monitoring and promoting healthy behaviors. Healthcare providers can also leverage the data generated by these devices to make informed decisions, personalize treatment plans, and intervene proactively. However, challenges exist, such as data security and privacy concerns, the accuracy of the collected information, and the need for effective integration into existing healthcare systems. Despite these challenges, the increasing adoption of wearable technology in chronic disease management reflects a promising avenue for improving patient outcomes and reducing healthcare costs through preventive and personalized care.
Reusable Ni‐Immobilized MOF Catalyst for Dehydrogenation of N‐Heterocycles Under Milder Conditions
Authors: Sk Motahar , Saifi Shadab , Bera Sourajit , Ghosh Adrija , Aijaz Arshad , Banerjee Debasis 
Published: December 2024

AbstractHerein, we have demonstrated the design and synthesis of a novel Ni‐immobilized MOF as heterogeneous catalyst for the dehydrogenation of N‐heterocycles. A series of five and six‐membered N‐heteroarenes bearing one or more heteroatoms were synthesized in up to 98 % yield (>33 examples). Late stage functionalization to the synthesis of β‐glucuronides inhibitor, antimalarial drug quinine, and the nonsteroidal anti‐inflammatory drug (NSAID) indomethacin were obtained under milder reactions conditions. A series of mechanistic studies revealed the detection of H2 and H2O2 during the progress of the reactions and suggested the involvement of enamine‐imine intermediate species for sequential dehydrogenation. Detailed characterization of the fresh catalyst and reused catalyst were performed using SEM, TEM, BET, PXRD, and EDX elemental mappings. The catalyst could be recycled up to four‐times without much loss in catalytic activities. In‐situ formed defects, pore size enlargement and additional Lewis acid sites within catalyst nanocrystals assisted in attaining high activity and selectivity to N‐heteroarenes.
Developmental and Adult Striatal Patterning of Nociceptin Ligand Marks Striosomal Population With Direct Dopamine Projections
Authors: Hueske Emily , Stine Carrie , Yoshida Tomoko , Crittenden Jill R. , Gupta Akshay , Johnson Joseph C. , Achanta Ananya S. , Bhagavatula Smitha , Loftus Johnny , Mahar Ara , Hu Dan , Azocar Jesus , Gray Ryan J. , Bruchas Michael R. , Graybiel Ann M. 
Published: December 2024

ABSTRACTCircuit influences on the midbrain dopamine system are crucial to adaptive behavior and cognition. Recent developments in the study of neuropeptide systems have enabled high‐resolution investigations of the intersection of neuromodulatory signals with basal ganglia circuitry, identifying the nociceptin/orphanin FQ (N/OFQ) endogenous opioid peptide system as a prospective regulator of striatal dopamine signaling. Using a prepronociceptin‐Cre reporter mouse line, we characterized highly selective striosomal patterning of Pnoc mRNA expression in mouse dorsal striatum, reflecting the early developmental expression of Pnoc. In the ventral striatum, Pnoc expression in the nucleus accumbens core was grouped in clusters akin to the distribution found in striosomes. We found that PnoctdTomato reporter cells largely comprise a population of dopamine receptor D1 (Drd1) expressing medium spiny projection neurons localized in dorsal striosomes, known to be unique among striatal projection neurons for their direct innervation of midbrain dopamine neurons. These findings provide a new understanding of the intersection of the N/OFQ system among basal ganglia circuits with particular implications for developmental regulation or wiring of striato‐nigral circuits.
Fuzzy‐Markov Routing Policy and Priority‐Based Load Balancing for Cognitive Radio Ad Hoc Networks
Authors: Sindhuja S. , Vadivel R. 
Published: December 2024

ABSTRACTA cognitive radio ad hoc network (CRAHNs) is an infrastructure‐free network containing a cognitive radio, which can use the spectrum resources effectively through an adaptive change of parameter settings and decision‐making. Hence, it enhances the spectrum efficacy for satisfying the growing mobile traffic requests. In multihop CRAHNs, in order to ensure a reliable transmission and energy efficiency, the routing protocol should consider the metrics of channel quality, link stability, and energy consumption. In this paper, a Fuzzy‐Markov routing policy and priority‐based load balancing algorithm (FMRP‐PLB) for CRAHNs is designed. In this protocol, a combined routing metric is derived using delay, energy rate, and link expiration time metrics. For modeling the channel state, a Fuzzy‐Markov decision model is designed, in which the channel states and spectrum availabilities of SU are modeled as state transition matrices. Then, optimum routing decisions are made using the combined routing metric and the predicted transmission success probability. A load balancing metric (LBM) is derived in terms of available link capacity, remaining buffer size of node, and back‐off delay. During data transmission, based on the traffic priority and measured levels of LBM, the optimum paths are selected. Simulation results using NS2 suggest that FMRP‐PLB attains an increased packet delivery ratio with reduced delay and energy consumption.
Greening the OECD: Unravelling the Complex Relationship Between Natural Resource Efficiency, Technological Innovation and Population Density on Ecological Footprint
Authors: Çabaş Meral , Beşer Nazife Özge , Ayaydın Hasan , Barut Abdulkadir , Magazzino Cosimo 
Published: December 2024

ABSTRACTThis paper aims to investigate the relationship among green environmental technologies, resource efficiency, population density and ecological footprint in 38 OECD member countries between 2000 and 2019. The Method of Moments Quantile Regression (MMQREG) and Augmented Mean Group (AMG) estimators are used to analyse this relationship. Based on the results, strong evidence of a negative relationship between green environmental technologies, resource efficiency, population density and ecological footprint emerges, suggesting that these factors contribute to environmental improvement in OECD economies. Overall, the findings contribute to a deeper understanding of the complex dynamics among these variables and provide valuable insights for policymakers and stakeholders striving for sustainable environmental management and policy formulation. In this context, countries should develop standard guidelines and best practices on green technologies and resource efficiency, making it easier for sectors to adapt in these areas.
Changes in Functional Connectivity Relate to Modulation of Cognitive Control by Subthalamic Stimulation
Authors: Achtzehn Johannes , Grospietsch Friederike , Horn Alexandra , Güttler Christopher , Horn Andreas , Marcelino Ana Luísa de Almeida , Wenzel Gregor , Schneider Gerd‐Helge , Neumann Wolf‐Julian , Kühn Andrea A. 
Published: December 2024

ABSTRACTSubthalamic (STN) deep brain stimulation (DBS) in Parkinson's disease (PD) patients not only improves kinematic parameters of movement but also modulates cognitive control in the motor and non‐motor domain, especially in situations of high conflict. The objective of this study was to investigate the relationship between DBS‐induced changes in functional connectivity at rest and modulation of response‐ and movement inhibition by STN‐DBS in a visuomotor task involving high conflict. During DBS ON and OFF conditions, we conducted a visuomotor task in 14 PD patients who previously underwent resting‐state functional MRI (rs‐fMRI) acquisitions DBS ON and OFF as part of a different study. In the task, participants had to move a cursor with a pen on a digital tablet either toward (automatic condition) or in the opposite direction (controlled condition) of a target. STN‐DBS induced modulation of resting‐state functional connectivity (RSFC) as a function of changes in behavior ON versus OFF DBS was estimated using link‐wise network‐based statistics. Behavioral results showed diminished reaction time adaptation and higher pen‐to‐target movement velocity under DBS. Reaction time reduction was associated with attenuated functional connectivity between cortical motor areas, basal ganglia, and thalamus. On the other hand, increased movement velocity ON DBS was associated with stronger pallido‐thalamic connectivity. These findings suggest that decoupling of a motor cortico‐basal ganglia network underlies impaired inhibitory control in PD patients undergoing subthalamic DBS and highlight the concept of functional network modulation through DBS.
Clinical Presentations and Surgical Features of Morgagni Hernia in Adults: A Retrospective Study
Authors: Mardani Parviz , Dalfardi Farzad , Bahmani Saman , Rahmati Rahem , Zarimeidani Fatemeh , Ziaian Bizhan , Amirian Armin , Vafabin Masoud , Shahriarirad Reza 
Published: December 2024

ABSTRACTBackground and AimsMorgagni hernias are rare congenital diaphragmatic defects that can lead to bowel obstruction and incarceration if not repaired. While this disease typically manifests as respiratory distress, frequent respiratory infections, and infant growth failure, it can sometimes be accidentally discovered in adulthood through cross‐sectional imaging. We aimed to report our experience managing this entity during 20 years at our referral center.MethodsA retrospective chart review was performed of adult patients diagnosed with Morgagni diaphragmatic hernia who underwent surgery at Shiraz University of Medical Sciences in two main referral hospitals between 2002 and 2022. Patients' demographic and clinical data, including surgical features and hospitalization, course were extracted and subsequently analyzed.ResultsSeventeen patients, including three men and 14 women, with an age range of 26 to 92 years (average age 61.5 years), were diagnosed with Morgagni diaphragmatic hernia. Three patients had left‐sided hernias, and 14 had right‐sided hernias. The most common clinical manifestations were shortness of breath and abdominal pain. The most commonly herniated contents were the omentum and colon. All patients underwent laparotomy, and the hernia sac was removed in 11 patients.ConclusionsMorgagni is a rare congenital diaphragmatic hernia usually diagnosed incidentally. Laparoscopic repair has high success rates and is a viable option for patients with this pathology.
Combination Effect of Phenylalanine‐Arginine‐Beta‐Naphthylamide and Curcumin on the Expression of the mexY Gene in Aminoglycoside‐Resistant Clinical Isolates of Pseudomonas aeruginosa
Authors: Charkhi Parisa , Haghshenas Mohammad Reza , Mirzaei Bahman , Khalili Younes , Goli Hamid Reza 
Published: December 2024

ABSTRACTBackground and AimsOverexpression of MexXY‐OprM efflux pump causes resistance to aminoglycosides in Pseudomonas aeruginosa. We aimed to investigate the relationship between resistance to aminoglycosides and the MexXY‐OprM expression level in P. aeruginosa clinical isolates without and after treatment with curcumin and/or phenylalanine‐arginine‐beta‐naphthylamide (PAβN) as the efflux pump inhibitors.MethodsWe collected 100 clinical isolates from hospitalized patients. The minimum inhibitory concentrations of aminoglycosides were determined by the micro‐broth dilution method in the presence and absence of PAβN and/or curcumin. Then, real‐time PCR was used to determine the expression level of the MexXY‐OprM efflux pump.ResultsIn this study, 34%, 35%, 10%, 38%, 43%, 42%, and 39% of the clinical isolates were resistant to gentamicin, tobramycin, amikacin, netilmicin, spectinomycin, kanamycin, and streptomycin, respectively. Also, 45% of the isolates showed an overexpression of the mexY gene, while 31 (68.88%) isolates exhibited a 2–3‐fold overexpression, and 14 (31.11%) isolates had a more than threefold overexpression of the mexY gene. However, 4 (8.88%) isolates showed a ≥ 10‐fold overexpression of this gene. The combination of PAβN with spectinomycin, netilmicin, streptomycin, and kanamycin exhibited a reduced MIC range of these aminoglycosides in 93.02%, 86.8%, 76.9%, and 71.4% of resistant isolates, respectively. Additionally, all gentamicin‐, tobramycin‐, kanamycin‐, streptomycin‐, and netilmicin‐resistant isolates showed a decreased MIC range in combination with curcumin. The most synergistic effect of curcumin and PAβN was observed in combination with spectinomycin, while the least synergistic effect was detected with kanamycin.ConclusionCurcumin can be a significant efflux inhibitor as an adjuvant in combination with aminoglycosides for successful treatment of patients infected by P. aeruginosa overexpressing the MexXY‐OprM efflux pump.
Zero‐Flow Dynamics for Headwater Streams in a Humid Forested Landscape
Authors: Leach Jason A. , Webster Kara L. , Hudson Danielle T. , Buttle James , Nehemy Magali 
Published: December 2024

ABSTRACTMuch of our understanding on temporary headwater streams is from arid and sub‐humid environments. We know less about zero‐flow periods in humid headwater catchments that experience seasonal snow cover. Our study characterised the temporal and spatial patterns of zero‐flow periods for forested headwater streams in a snow‐dominated landscape. We used 36 years of streamflow data from 13 headwater catchments within the Turkey Lakes Watershed located on the Canadian Shield in Ontario, Canada, near the eastern shores of Lake Superior. These headwater catchments differ substantially in their number of May–November zero‐flow days (0–166 days per year) despite being clustered in a small geographical area with similar geology, physiography and vegetation cover. The catchments also experience similar continental climatic conditions with relatively even precipitation inputs throughout the year (mean annual precipitation of 1210 mm/year). Inter‐annual variability in the number of zero‐flow days was primarily associated with May–November precipitation and evapotranspiration. Despite the large seasonal snowpacks that form in this region, the amount of snow did not appear to influence the extent of zero‐flow periods. We found that between‐catchment variability in zero‐flow occurrences was related to differences in catchment area and catchment properties typically associated with greater groundwater influence. Our study suggests that occurrences of zero‐flows in headwater streams can be highly variable even over small geographical regions and that flow permanence may be more sensitive to spring to fall weather conditions than the influence of snow due partly to the shallow soils typically found on the Canadian Shield.
Treatment of recurrent priapism using proximal shunt: Quackles technique
Authors: Toledo Jiménez Miguel , Carracedo Calvo David , Moscatiello Pietro , Fiorillo Alessandro , Quintana Álvarez Rebeca , Pereira Rodríguez Nathalie , Hernández Bermejo Irene , Miñana Toscano Iñigo , Sánchez Encinas Miguel 
Published: December 2024

IntroductionRecurrent priapism is a rare variant of ischemic priapism that involves recurrent erections typically lasting less than 4 h. The primary goal of treatment is to prevent future episodes, with options ranging from pharmacological treatments to various surgeries.Case presentationA 38‐year‐old man experienced multiple episodes of priapism that were refractory to angioembolization of an arteriocavernous fistula and oral treatment with Cetirizine and Bicalutamide. After the patient refused intracavernous self‐injections, various surgical options were considered. Ultimately, a proximal penile shunt surgery with a cavernosal–spongiosal shunt using the Quackles technique was chosen, which proved effective in preventing episodes and did not affect the patient's erectile function.ConclusionPenile shunt surgery using the Quackles proximal technique is a safe and effective option for the treatment of recurrent priapism.
RIS–Assisted Propagation Control in CDMA‐FBMC‐OQAM System
Authors: Patra Radhashyam , Mahapatro Arunanshu 
Published: December 2024

ABSTRACTThis framework incorporates the Reconfigurable Intelligent Surface (RIS)–assisted propagation control in Code Division Multiple Access‐Filter Bank MultiCarrier‐Offset Quadrature Amplitude Modulation (CDMA‐FBMC‐OQAM) system. In this system, the modulated signal is reflected by the RIS, which is composed of many tiny passive reflecting elements, and then transmitted through the channel to the receiver. The multiple reflected signals from the RIS are collected at the receiver and then FBMC demodulated and then CDMA despread, which improves the Instantaneous Signal‐to‐Noise‐Ratio (ISNR) of the detected signal. As a result, Bit‐Error‐Probability (BEP) performance is improved.
Improving the Efficiency of Electrostatic Embedding Using the Fast Multipole Method
Authors: Colinet Pauline , Neese Frank , Helmich‐Paris Benjamin 
Published: December 2024

ABSTRACTThis paper reports the improvement in the efficiency of embedded‐cluster model (ECM) calculations in ORCA thanks to the implementation of the fast multipole method. Our implementation is based on state‐of‐the‐art algorithms and revisits certain aspects, such as efficiently and accurately handling the extent of atomic orbital shell pairs. This enables us to decompose near‐field and far‐field terms in what we believe is a simple and effective manner. The main result of this work is an acceleration of the evaluation of electrostatic potential integrals by at least one order of magnitude, and up to two orders of magnitude, while maintaining excellent accuracy (always better than the chemical accuracy of 1 kcal/mol). Moreover, the implementation is versatile enough to be used with molecular systems through QM/MM approaches. The code has been fully parallelized and is available in ORCA 6.0.
A patient with a PTPN11 gene variant complicated with Chiari I malformation and syringomyelia and a review of literatures
Authors: Yi Zhi , Xue Jiao , Song Zhenfeng , Li Fei , Yang Chengqing , Zhang Ying 
Published: December 2024

AbstractBackgroundAccording to previous literature reports, PTPN11 gene variants account for approximately 50% of Noonan syndrome (NS) cases and 85% of Leopard syndrome (LS) cases. Several patients who were diagnosed with NS or LS complicated with Chiari I malformation (CIM) and/or syringomyelia have been reported to have a PTPN11 variant. However, it is not always clear whether the association between CIM and/or syringomyelia and PTPN11 variants is real or random. We try to explain this phenomenon by reporting a clinical case and making a mini‐review.MethodsWe retrospectively described a clinical case in detail and made a genetic test on the proband and her family members using whole‐exome sequencing. And made a review of the related literatures.ResultsThe patient was manifesting progressive abnormal gait and muscle weakness for more than 2 years before she was admitted to our hospital at the age of 5 years and 2 months. On examination, she looked frail and slender. She had short stature, mild intellectual disability, decreased muscle strength in the left limb, thinner left limb, left hollow foot and foot drop, weakened left knee and Achilles tendon reflexes and a positive left Babinski sign. She looked timid and had very little expressive language. MRI of the brain and spine revealed CIM and syringomyelia with hydrops. Cardiac ultrasonography revealed an ostium secundum defect. ECG examination showed no abnormalities. She received a spinal cavity subarachnoid shunt; the symptoms were relieved to some extent, and the cavity in the lumbar vertebrae was significantly reduced after the surgery. Genetic testing found a variant, c. 922A>G (p. Asn308Asp) in the PTPN11 gene. Both parents were wild‐type at this locus. A literature review found that 31 patients with NS or LS were complicated with CIM, syringomyelia or both. Together with our patient, a total of six patients in this group had the PTPN11 gene variant. Among them, four were complicated with both CIM and syringomyelia, and two were complicated with CIM only.ConclusionsWe report another case with a PTPN11 variant that was complicated with both CIM and syringomyelia. It suggests that CIM and syringomyelia may be clinical manifestations of PTPN11 variation‐related diseases. This phenomenon may be underrated due to limitations of genetic diagnostic methods in the past. We strongly suggest routine craniocerebral and spinal MRI scans and genetic testing for patients suspected of having NS or LS.
A Survey Assessing Nonalcoholic Fatty Liver Disease Knowledge Among Hepatologists and Non‐Hepatologists in China
Authors: Colombo Laura 
Published: December 2024

ABSTRACTBackground and AimA global increase in nonalcoholic fatty liver disease (NAFLD) prevalence has been observed in the last decade. This study assesses knowledge, awareness, and clinical practice gaps of hepatologists and non‐hepatologists in NAFLD management across hospitals in China.MethodsA web‐based quantitative survey was conducted, and participants included hepatologists (gastroenterologists and infectious disease specialists) and non‐hepatologists (internal medicine specialists, cardiologists, and pharmacists) from various hospitals across China.ResultsIn total, 1627 healthcare practitioners (HCPs) responded to the survey. This included 658 hepatologists and 969 non‐hepatologists. In comparison to 92.6% hepatologists, only 58.0% of non‐hepatologists were aware of NAFLD. A higher proportion of hepatologists (82.8%) performed screening for NAFLD compared to non‐hepatologists (56.9%). Majority of the hepatologists (70%) and non‐hepatologists (67%) were aware of the four primary recommendations for managing NAFLD. Only 11% of hepatologists did not manage NAFLD patients, mainly because they felt they did not have enough time (66.7%). Of the 36% non‐hepatologists who did not manage NAFLD, 78.4% stated that NAFLD is not their specialty, and 38.6% were not familiar with the treatment options.ConclusionMost hepatologists were aware of and agreed to performing screening for NAFLD compared to non‐hepatologists. Both hepatologists and non‐hepatologists exhibited similar level of understanding on NAFLD management. However, a small percentage of both hepatologists and non‐hepatologists admitted that they did not manage NAFLD patients because they were not familiar with available treatment options. This underscores the importance of further educating HCPs involved in managing NAFLD.