bluuebunny/crossref_metadata_2025_split huggingface dataset:
Within-person, longitudinal associations between neighborhood cohesion and adult mental health: A test of bidirectional relations
Authors: Prati Gabriele 
Published: November 2024

Background: There is theory and evidence supporting a relationship between neighborhood cohesion and mental health among adult people. However, most studies have used a cross-sectional design, and longitudinal studies have provided mixed support for this hypothesis. Moreover, while neighborhood cohesion is assumed to be a consistent predictor of mental health, the possibility of a reciprocal relation has been overlooked. Aim: The aim of the current study was to investigate the within-person reciprocal associations between neighborhood cohesion and adult mental health. Methods: This study used data from Understanding Society: the UK Household Longitudinal Study including waves 1, 3, 6, 9, and 12 ( n = 81,895). A short version of Buckner’s Neighborhood Cohesion Instrument was used, along with two well-established measures of mental health: the 12-item General Health Questionnaire and the mental component summary score of the 12-item Short-Form Health Survey. Results: Hierarchical Bayesian continuous time dynamic modeling revealed significant reciprocal within-person cross-effects (i.e. deterministic effects) between neighborhood cohesion and adult mental health, a larger standardized effect of mental health on neighborhood cohesion than than vice versa. Moreover, peak standardized cross-lagged effects were found for a time interval of approximately 1 year. Finally, the combined stochastic and deterministic interpretation revealed effects of neighborhood cohesion on mental health that were opposite to what was expected, suggesting a faster dissipation of some initially correlated change. Conclusion: Although neighborhood cohesion has traditionally been conceptualized in terms of its contribution to mental health, there is greater support for the view that mental health precedes neighborhood cohesion rather than the reverse.
Integrating AI Into Education: Successful Strategies, Ideas, and Tools From Psychology Instructors
Authors: Costa Christina , Husain-Habib Nahid , Reiter Alyssa 
Published: November 2024

Background Integrating artificial intelligence (AI) into psychological education represents an opportunity in teaching methodologies, offering possibilities for instructors. Despite its potential, there is a significant gap in knowledge regarding how psychology instructors implement AI tools in their teaching practices. Objective The primary objective of this study was to explore how psychology instructors utilize AI tools. Method This study employed semistructured interviews with 15 psychology instructors. Interviews were transcribed and subjected to thematic analysis. Results The study revealed key motivations for AI integration: preparing students for the workforce, enhancing academic integrity, aligning with institutional goals, and addressing potential challenges. Additionally, various methods of AI integration were explored, focusing on fostering critical thinking, supporting research and writing, and promoting ethical AI use. Challenges such as inconsistent AI policies, varied student proficiency, ethical concerns, and difficulties with prompt engineering were highlighted. Conclusion This study shows that AI integration in psychology education is done in a myriad of ways, and instructors demonstrate creative approaches to how to implement AI and the potential challenges. Teaching Implications Psychology instructors can consider integrating AI tools into their coursework. Additionally, educators can address potential challenges by providing clear AI usage guidelines and offering tailored.
Extended use of axillary impella 5.5 as a bridge to post-infarct ventricular septal defect repair
Authors: Gregory Vasiliki , Zias Ariadne , Isath Ameesh , Spielvoge David , Ohira Suguru 
Published: November 2024

Post-infarct ventricular septal defect (VSD) carries high mortality. Since emergent repair of post-infarct VSD is challenging, hemodynamic stabilization utilizing temporary mechanical circulatory support crucially provides time to delay intervention and allows necessary scar tissue formation which improves the fragility of myocardium and leads to a definitive repair. To date, there remains no standard for achieving hemodynamic stability, including usage and mode of temporary mechanical circulatory support. We describe a patient with acute post-infarct VSD in cardiogenic shock successfully supported with Impella 5.5 for 67 days as a bridge to surgical repair and coronary artery bypass grafting.
Complication rate with the 1940-nm versus 1470-nm wavelength laser
Authors: Keo Hak Hong , Gondek Karoline , Diehm Nicolas , Leib Christoph , Uthoff Heiko , Engelberger Rolf P , Staub Daniel 
Published: November 2024

Background We hypothesized, that endovenous laser ablation (EVLA) with the highly water specific 1940-nm wavelength laser would reduce ablation-related thrombus extension (ARTE) incidence compared to the less specific 1470-nm laser. Materials and methods Between February 2017 to March 2023 we identified a consecutive series of patients undergoing EVLA from the prospectively ongoing VEINOVA registry. Patients were treated with the 1940-nm or 1470-nm laser. Demographic data and outcome data were used for this retrospective analysis. Results From a total of 3055 EVLA, 2006 procedures were performed with the1470-nm and 1049 with the 1940-nm laser. At 2–6 days follow- up visit (follow up visit 1), all ARTE occurred in 18 (0.9%) of all procedures with the 1470-nm and in 1 (0.1%) with the 1940-nm laser ( p = 0.023). DVT was similar in both groups (0.3% vs 0.2%, p = 0.784). Phlebitis occurred in 67 (3.3%) of all procedures with the 1470-nm and in 2 (0.2%; p = 0.003) with the 1940-nm laser and paresthesia in 99 (4.9%) versus 5 (0.5%; p < 0.001), respectively. At 5–6 weeks follow-up (follow up visit 2), all ARTE occurred in 27 (1.4%) of all procedures with the 1470-nm and in 4 (0.4%; p = 0.010) with the 1940-nm laser. DVT was similar in both groups (0.7% vs 0.4%; p = 0.846). Phlebitis occurred in 97 (4.8%) of all procedures with the 1470-nm and in 9 (0.9%; p < 0.001) with the 1940-nm laser and paresthesia in 194 (9.7%) versus 35 (3.3%; p < 0.001), respectively. Occlusion rate was in both groups similar (99.8% vs 99.6%). Conclusion EVLA using the 1940-nm laser appears to be safe with lower ARTE incidence than using the 1470-nm laser. Phlebitis and paresthesia occurred less frequent with the 1940-nm than with the 1470-nm laser, thus favoring the use of the 1940-nm laser.
Mechanical and dynamic characteristics for the CFRP, GFRP, and hybrid composites exposed to HCl environment
Authors: Coskun Taner , Sozen Betul , Kapıcı Serkan , Sahin Omer Sinan 
Published: November 2024

In the current study, the low-velocity impact (LVI) characteristics of carbon fiber-reinforced polymer (CFRP), glass fiber-reinforced polymer (GFRP), and hybrid composites before and after the corrosive environment exposure were investigated. In this regard, CFRP, GFRP, and hybrid composites were subjected to LVI and tensile loadings after being kept in a 10% diluted HCl environment for 1 week and 1 month, and the impacts of the corrosive environment on the composites’ dynamic and mechanical responses were determined by comparing the outcomes of the control and aged specimens. LVI tests for CFRP, GFRP, and hybrid composites were carried out by transferring 25.2 and 11.2 J impact energy to the specimens with two impact velocities of 3 and 2 m/s, respectively, and thus, the effects of impact energy and hybridization were investigated. Moreover, tensile tests were conducted for the control and aged specimens with 2 mm/min crosshead speed, and thus, the effects of fiber material, hybridization, and corrosive environment on the mechanical properties were determined. The study found that CFRP composites had higher stiffness than GFRPs, whereas hybrid composites exhibited dynamic responses between CFRP and GFRP, as expected. On the other hand, it turned out that the composites absorbed most of the impact energy, which was interpreted as being absorbed by the damage of fiber-reinforced composites, which stand out with their brittle characteristics. Furthermore, it was discovered that the damage severity elevated as expected with a longer aging time, which was attributed to the corrosive liquid attacking the fibers, matrix, and fiber/matrix interfaces and reducing strength. It was also observed that, as predicted, the corrosive effects generally resulted in a reduction in tensile responses, including ultimate strain and tensile strength.
An SBM and TBSS Analysis in Early-stage Patients With Alzheimer’s Disease, Lewy Body Dementias, and Corticobasal Syndrome
Authors: Giannakis Alexandros , Vartholomatos Evrysthenis , Astrakas Loukas , Anyfantis Emmanouil , Tatsioni Athina , Argyropoulou Maria , Konitsiotis Spiridon 
Published: November 2024

Objective To compare gray matter (GM) and white matter (WM) changes in patients with Alzheimer’s disease (AD), Lewy body dementias (LBD), corticobasal syndrome (CBS), and healthy controls (HC). Methods Surface-based morphometry (SBM) was assessed on 3D T1-weighted images using FreeSurfer image analysis and WM microstructure was studied using Tract-Based Spatial Statistics (TBSS) in 12 AD, 15 LBD, 10 CBS patients, and 10 HC. Results Patients with AD, compared with HC, exhibited reduced cortical surface area and volume in the superior frontal, middle frontal, and medial orbitofrontal cortex. In TBSS, AD patients, compared with HC and LBD, displayed decreased fractional anisotropy, axial diffusivity, and increased radial diffusivity in all major WM tracts. Other comparisons between the groups yielded no differences, either in the SBM or the TBSS analysis. Conclusions The results indicate significant early structural changes in the GM of the frontal lobe, along with WM alterations early in AD patients.
Real world application of the 2023 ACR/EULAR antiphospholipid antibody syndrome classification criteria in a pharmacist directed anticoagulation clinic
Authors: DeFazio Catherine , Horvath Lara , Morgan Jennifer , Murphy Meaghan B. , Shtoyko Ashley N. , Phillips Elizabeth M. 
Published: November 2024

Objectives To determine the number of patients that met classification for antiphospholipid antibody syndrome (APS) after applying the 2023 American College of Rheumatology and the European Alliance for Associations of Rheumatology (ACR/EULAR) classification criteria, to identify reasons patients did not meet the new criteria, and determine the number of patients who were single, double, or triple positive based on laboratory criteria. Methods A single center, retrospective chart review of patients with APS on anticoagulation managed by ambulatory care clinical pharmacists. Data collected included patient demographics, type of anticoagulation, and clinical and laboratory criteria for APS as defined by the 2023 ACR/EULAR criteria. Data is presented using descriptive statistics. Results A total of 51 patients previously diagnosed with APS were included. There were 42 patients on warfarin (82.3%), 4 patients on direct oral anticoagulants (19%), 3 patients on low molecular weight heparin (5.8%), and 2 patients on fondaparinux (3.9%). Of the 51 patients, 12 (23.5%) met classification criteria, 33 (64.7%) did not meet classification criteria and 6 (11.7%) had insufficient data. Of the 27 patients that did not meet criteria, 13 patients did not meet the laboratory criteria (39.4%), 6 patients did not meet the clinical criteria (18.2%) and 14 patients did not meet both laboratory and clinical criteria (42.4%). Of the 12 patients that met classification criteria, 2 patients were triple positive (16.7%), 3 were double positive (25%), and 7 were single positive (58.3%). Conclusions Results from this study indicate that APS continues to be a complex disease state with challenges in diagnosis and classification. Since only a small number of patients in our clinic continued to meet the classification criteria, opportunities for patient re-evaluation of management strategies at our institution could be considered.
Triage ethics in mass casualty incident simulation: A phenomenological exploration
Authors: Watson Adrianna Lorraine , Drake Jeanette , Anderson Matthew , Heaston Sondra , Schmutz Pyper , Reed Calvin , Rasmussen Rylie 
Published: November 2024

Background Disaster scenarios challenge both novice and experienced nurses to navigate complex ethical dilemmas in resource-limited environments. Traditional nursing education often leaves new nurses unprepared for the ethical demands of disaster nursing. Utilitarianism must often guide triage ethics and decision-making. There is a critical need to equip nursing students with these ethical competencies. Research question/Aim This study explores nursing students’ lived experiences using introductory triage ethics in mass casualty incident simulation (MCIS). Research design A qualitative, interpretive phenomenological approach was employed, analyzing reflective journal responses from senior nursing students following MCIS participation. Participants and research context Participants were senior-year nursing students from a private university in the U.S., engaging in MCIS as part of their curriculum, which simulated resource-limited disaster scenarios requiring real-time ethical decisions. Ethical considerations The study received Institutional Review Board (IRB) approval, and participants provided informed consent. Data were anonymized and did not affect academic evaluation. Findings Two major themes emerged: 1. Living in Ethical Dilemmas (subthemes: We Could Have Saved Them If…, Looking Past Obvious Suffering, How Can We Be Prepared?, We Can’t Abandon Them). 2. Development of Ethical Competency (subthemes: Knowing You’ve Done Enough, Finding New Perspectives, There Is No Right Answer). Students grew in moral reasoning and emotional resilience, transitioning from patient-centered care to utilitarian decision-making. Conclusions Participation in the mass casualty incident simulation allowed nursing students to confront and navigate complex ethical challenges in real time, fostering significant growth in moral reasoning and emotional resilience. Through immersion in simulated ethical dilemmas, students grappled with the tension between patient-centered care and the realities of utilitarian decision-making. This experience catalyzed a deeper understanding of ethical ambiguity and the development of moral clarity, equipping them with foundational skills for ethically navigating crises. Nursing curricula should recognize and incorporate opportunities that facilitate this ethical growth through experiential learning.
Four-Week GLP Immunotoxicity Assessment of Lactoferrin Alpha Produced by Komagataella phaffii in Sprague-Dawley Rats
Authors: Peterson Ross , Crawford Robert B. , Blevins Lance K. , Kaminski Norbert E. , Clark Anthony J. , Malinczak Carrie-Anne 
Published: November 2024

Oral toxicity and toxicokinetic properties of human lactoferrin (LF) alpha produced in Komagataella phaffii (effera™) were investigated in adult Sprague-Dawley rats over a 28-day period under good laboratory practice conditions. Main study dosing used groups of 10 rats/sex/dose, and a secondary study evaluating toxicokinetic parameters used 6 rats/sex/dose. The vehicle control group received sodium citrate buffer, test groups received daily doses of 200, 600, and 2000 mg of effera™ per kg body weight, and the comparative control group received 2000 mg bovine LF (bLF)/kg body weight per day. T-cell-dependent antibody response against keyhole limpet hemocyanin and immunophenotyping of the spleen were performed as measures of immunotoxicity. Clinical observations, body weight, hematology, coagulation, clinical chemistry, urinalysis, immunotoxicity, gross necropsy, and histopathology were assessed. Toxicokinetic parameters were analyzed as an indication of LF bioavailability, and anti-LF antibody assays were conducted to detect antibodies produced against LF to measure immunogenicity. No treatment related toxicologically significant changes were observed. Based on the absence of toxicologically relevant changes, effera™ is well tolerated in rats at doses up to 2000 mg rhLF/kg/day, an amount ∼400 times that of the estimated daily intake at the 90th percentile proposed for human adult use.
Serological and molecular detection of Toxoplasma gondii in cats in Europe with evaluation of associated risk factors for pathogen contact/infection
Authors: Schäfer Ingo , Binder Franka , Kerner Katharina , Breu Doris , Müller Elisabeth 
Published: November 2024

Objectives Toxoplasma gondii is an obligate intracellular coccidian pathogen, with domestic cats and other members of the Felidae family serving as its definitive hosts. The aim of the study was to identify risk factors for positive test results. Methods A laboratory database was screened for T gondii PCR results from faecal samples and serology results (IgM, IgG) from serum/plasma taken from cats in Europe between January 2008 and December 2022. Logistic regression analysis was performed to identify risk factors associated with positive T gondii results, such as breed, age, sex, neuter status, regionality, seasonality, feline leukaemia virus (FeLV) and feline immunodeficiency virus (FIV) status. Odds ratios (ORs) were calculated. Results A total of 45,523 cats were included: 14,500 (31.9%) tested positive by direct and/or indirect detection methods for T gondii (PCR: 126/7896 [1.6%], IgG: 14,148/37,882 [37.3%], IgM: 1539/37,882 [4.1%]). Age >5 years (IgG: OR 2.591, P <0.001; IgM: OR 1.954, P <0.001), European domestic shorthair cats/cross breeds (IgG: OR 3.848, P <0.001; IgM: OR 2.152, P <0.001), male sex (IgG: OR 1.134, P <0.001), neuter status in male (IgG: OR 0.536, P <0.001) and female cats (IgG: OR 0.577, P <0.001), FeLV antigen positivity (IgG: OR 1.358, P = 0.030) and FIV antibody positivity (IgG: OR 2.350, P <0.001; IgM: OR 2.650, P <0.001) significantly impacted the serological results. In PCR testing, neuter status had a significant impact in male (OR 2.455, P = 0.002) and female cats (OR 2.988, P <0.001). Serological and PCR results were significantly influenced by regionality for IgG (central: OR 1.454, P <0.001; north: OR 0.768, P <0.001; south: OR 0.526, P <0.001; east: OR 0.768, P <0.001; west: OR 0.709, P <0.001), IgM (central: OR 0.616, P <0.001; north: OR 1.456, P <0.001; south: OR 1.767, P <0.001; east: OR 1.456, P <0.001) and PCR testing (central: OR 0.460, P <0.001; north: OR 3.020, P = 0.002; east: OR 3.020, P = 0.002). Seasonality had a statistically significant impact on IgM (summer: OR 1.402, P <0.001; winter: OR 0.732, P <0.001) and PCR testing (autumn: OR 1.473, P = 0.038). Conclusions and relevance Breed, age, sex, neuter status, seasonality and regionality significantly impacted serological results. Neuter status, seasonality and regionality significantly impacted the PCR results. Immunosuppression (FeLV/FIV) had a significant impact on serological results. PCR-positive cats shed oocysts and spread infection to other susceptible hosts, including humans. Surveillance is therefore recommended, taking into consideration the associated risk factors.
Predicting Calcein Release from Ultrasound-Targeted Liposomes: A Comparative Analysis of Random Forest and Support Vector Machine
Authors: Shomope Ibrahim , Percival Kelly M. , Abdel Jabbar Nabil M. , Husseini Ghaleb A. 
Published: November 2024

The type of algorithm employed to predict drug release from liposomes plays an important role in affecting the accuracy. In recent years, Machine Learning (ML) has shown potential for modeling complex drug delivery systems and predicting drug release dynamics with a greater degree of precision. In this regard, Random Forest (RF) and Support Vector Machine (SVM) are two ML algorithms that have been extensively applied in various biomedical and drug delivery contexts. Yet, direct comparisons of their predictive accuracy in modeling ultrasound-triggered drug release from liposomes remain limited. Existing studies predominantly focus on drug release under static conditions or with limited external stimuli rather than the dynamic, nonlinear responses observed under ultrasound exposure. Objective This study presents a comparative analysis of RF and SVM for predicting calcein release from ultrasound-triggered, targeted liposomes under varied low-frequency ultrasound (LFUS) power densities (6.2, 9, and 10 mW/cm2). Methods Liposomes loaded with calcein and targeted with seven different moieties (cRGD, estrone, folate, Herceptin, hyaluronic acid, lactobionic acid, and transferrin) were synthesized using the thin-film hydration method. The liposomes were characterized using Dynamic Light Scattering and Bicinchoninic Acid assays. Extensive data collection and preprocessing were performed. RF and SVM models were trained and evaluated using mean absolute error (MAE), mean squared error (MSE), coefficient of determination (R²), and the a20 index as performance metrics. Results RF consistently outperformed SVM, achieving R2 scores above 0.96 across all power densities, particularly excelling at higher power densities and indicating a strong correlation with the actual data. Conclusion RF outperforms SVM in drug release prediction, though both show strengths and apply based on specific prediction needs.
Evolving Methods and Application of a 3D Printed Model in the Current Deep Inferior Epigastric Perforator Flap Elevation
Authors: Woo Soo Jin , Kim Su Yong , Ahn Il Young , Hong Ki Yong , Choi Jinil , Lee Se Yeon , Kim Woo Ju , Kim Sun Joo , Kang Shin Hyuk , Chang Hak 
Published: November 2024

Background The choice of the deep inferior epigastric perforator (DIEP) flap for breast reconstruction has increased. Three-dimensional (3D) models of DIEP flaps have been introduced with advances in 3D technology to assist the tedious intramuscular dissection of the pedicle. This study presents the process of creating an ideal 3D model for a DIEP flap. Methods Collaboration among various professionals, including surgeons, radiologists, and 3D-printing model makers, is essential for manufacturing suitable 3D-printing DIEP models. Our team facilitated the collaboration process by sharing the virtual 3D model via a uniform resource locator (URL) using an online platform accessible on mobile devices. Results During collaboration in 3D DIEP model-making, we continuously upgraded the model to a better version. The model was modified according to the surgeon’s preference from a 1:1 ratio size to a handheld size. Additionally, we achieved significant advancements over conventional methods, including improved visualization of detailed vessel pathways with separation of arteries and veins, tissue transparency, and superficial inferior epigastric vein (SIEV). Conclusions Through 3D model-making collaborations, our team successfully developed a 3D DIEP model with translucency and visualized arteries and veins separately with accentuation of the perforators, including SIEV tracing, which is more accurate. This ideal 3D model for the DIEP flap enables the selection of a perforator vessel that is safe and easy to dissect to lower complications and procedure time and will be of great help to less experienced surgeons.