bluuebunny/crossref_metadata_2025_split huggingface dataset:
Complete Genome Sequence of a Novel Human Gammapapillomavirus Isolated from a Cervical Swab in Luxembourg
Authors: Latsuzbaia Ardashel , Arbyn Marc , Dutta Sankhadeep , Fischer Marc , Gheit Tarik , Tapp Jessica , Tommasino Massimo , Weyers Steven , Mossong Joël 
Published: March 2018

ABSTRACT
A novel human papillomavirus genotype was detected in a cervical swab specimen by next-generation sequencing after rolling circular amplification. It was fully cloned and characterized. The L1 open reading frame showed 77% nucleotide similarity with the closest genotype, HPV101, belonging to the gamma-6 species.
Draft Genome Sequences of Two Dickeya dianthicola Isolates from Potato
Authors: Cai W. , Srivastava S. K. , Stulberg M. J. , Nakhla M. K. , Rascoe J. 
Published: March 2018

ABSTRACT

Here, we report two annotated draft genome sequences of
Dickeya dianthicola
isolates from potatoes collected in Delaware and West Virginia. The genomes of strains DE440 and WV516 show 99% similarity to each other and 96% and 95% similarity to the European strains IPO 980 and RNS04.9, respectively.
Complete Genome Sequences of the Probiotic Lactic Acid Bacteria
Lactobacillus helveticus
D75 and D76
Authors: Toropov V. A. , Vakhitov T. Y. , Shalaeva O. N. , Roshchina E. K. , Sitkin S. I. 
Published: March 2018

ABSTRACT

Lactobacillus helveticus
D75 and D76 were isolated from the intestinal tract of a healthy child. Both strains possess symbiotic, probiotic, and antagonistic activities. We have sequenced and annotated the whole genomes of
L. helveticus
D75 and D76 and have conducted a preliminary genome comparative analysis.
Characteristics of participants who withdraw from surgical simulation-based educational research
Authors: Vega Vega Camila , Gostlow Hannah Claire , Marlow Nicholas , Babidge Wendy , Maddern Guy 
Published: March 2018

IntroductionThe problems associated with recruitment and retention of patients in clinical trials have been widely addressed in literature; however, similar problems associated with healthcare workers are rarely reported. The aim of this paper is to outline the factors that can impede a participant’s successful participation in a research project and to analyse the characteristics of participants that withdrew.MethodsThe Laparoscopic Simulation Skills Program (LSSP) was a prospective randomised cohort study investigating the efficacy of self-directed learning for basic laparoscopic skills acquisition. Two hundred and seven medical students, junior doctors, as well as surgical and gynaecology trainees were enrolled between June 2015 and November 2016.ResultsFifty-six (27%) participants failed to attend the final assessment. Of these, 43 participants (77%) responded to the follow-up survey and/or phone contact regarding non-attendance. Most participants failed to attend due to lack of free time/conflicting clinical duties and university requirements. Participants who did not attend the final assessment and did not provide further responses were less motivated by a career in surgery, surgical simulation and perceived less benefits of laparoscopic simulation. The 43 participants who answered the survey and/or phone contact provided similar responses to the participants who completed the study requirements and had more intrinsic motivators to enrol.ConclusionsClinical duties and other educational commitments are the biggest barriers to participation in simulation based-education research.
Change in cardiovascular risk factors in patients who develop psoriatic arthritis: longitudinal data from the Nord-Trøndelag Health Study (HUNT)
Authors: Gulati Agnete Malm , Salvesen Øyvind , Thomsen Ruth Stoklund , Kavanaugh Arthur , Semb Anne Grete , Rollefstad Silvia , Haugeberg Glenn , Hoff Mari 
Published: March 2018

ObjectivesThe aim of this population-based study was to compare changes in cardiovascular (CV) risk factors over a decade-long period in patients who developed psoriatic arthritis (PsA) and the background population.MethodsPatients diagnosed with PsA (n=151) between 1998 and 2008 and matched controls (n=755) who participated in both the Nord-Trøndelag Health Study (HUNT) 2 (1995–1997) and HUNT3 (2006–2008) were included. Mixed linear and logistic models were used to analyse the difference in mean change between HUNT2 and HUNT3 in patients and controls for body mass index (BMI), total cholesterol (TC), triglycerides, low-density lipoprotein cholesterol (LDL-c), high-density lipoprotein cholesterol (HDL-c) and blood pressure (BP).ResultsAt baseline (HUNT2), the patients who developed PsA compared with controls had higher BMI (27.2 vs 25.9 kg/m2, p<0.001) and lower HDL-c (1.32 vs 1.40 mmol/L, p<0.03) and more were smokers (41.1 vs 28.5%, p<0.01). Seventy-eight per cent had skin psoriasis. The mean PsA disease duration at HUNT3 was 4.8 (+/–3.0) years. The patients who developed PsA gained less weight from HUNT2 to HUNT3 compared with the control group (2.1 vs 3.9 kg, difference in mean change −1.8 kg, 95% CI −3.9 to −0.5, p<0.01). TC, triglycerides, LDL-c or HDL-c values and BP declined in both groups, with no significant differences between groups.ConclusionLongitudinal 10-year data did not show an increase in CV risk factors in patients who developed PsA compared with controls. This study implies that unfavourable CV risk factors in PsA were present before the diagnosis was established.
Ab initiostudy of naphthalene and anthracene elastic properties
Authors: Prazyan Tigran L. , Zhuravlev Yuri N. 
Published: March 2018

A study of the crystal structure, mechanical and acoustic properties of two [Formula: see text] and [Formula: see text] monoclinic phases of naphthalene and anthracene was performed using ab initio method of linear combination of atomic orbitals (LCAO) and basis sets: C_6-21G*, H_3-1p1G. The method was implemented in the CRYSTAL[Formula: see text]14,[Formula: see text]17 software package using electron density functional theory including van der Waals interactions (DFT-D2 and DFT-D3 (BJ)), in the local density approximation (LDA) with VWN exchange-correlation potential, gradient approximation PBE exchange-correlation functional and B3LYP hybrid functional. The calculated elastic constants for the first time are in moderate agreement with experimental data. Bulk modulus [Formula: see text], shear modulus [Formula: see text], Young’s modulus [Formula: see text] and the Poisson’s ratio [Formula: see text], as well as acoustic properties (average velocity of sound [Formula: see text], the Debye temperature [Formula: see text], and acoustic Grüneisen parameter [Formula: see text]) were obtained using the Voigt–Reuss–Hill model.
Multi-Criteria Decision Making for PLM Maturity Analysis based on an Integrated Fuzzy AHP and VIKOR Methodology
Authors: Yu Xi , Zhang Haiqing , Bouras Abdelaziz , Ouzrout Yacine , Sekhari Aicha 
Published: March 2018

A wide range of product lifecycle management (PLM) maturity models are proposed to assess the relative position of companies on their road to complete PLM implementation. However, it is a tough job for the company to dynamically evaluate the gradual process of PLM maturity by using existing values and accurately make decisions of improving PLM maturity by selecting the optimum alternative. A fuzzy PLM components maturity model (PCMA) is presented to build the internal logical relationship between maturity levels and existing values that can automatically predict the unknown PLM maturity levels. A fuzzy AHP–VIKOR methodology is used to make a decision among option PLM strategies. The weights of the criteria are determined by fuzzy pairwise comparison matrices (PCM). The weights of alternatives with respect to criteria are calculated by fuzzy VIKOR. The fuzzy AHP–VIKOR is a compromise solution and has the ability of transfer subjective and implicit linguistics into objective and transparent data. A numerical example illustrates and clarifies the running steps of the proposed methodology.
Effects of phase correlations in naturalistic stimuli on quantitative information coding by fly photoreceptors
Authors: Ignatova Irina I. , French Andrew S. , Frolov Roman V. 
Published: March 2018

Natural visual scenes are rarely random. Instead, intensity and wavelength change slowly in time and space over many regions of the scene, so that neighboring temporal and spatial visual inputs are more correlated and contain less information than truly random signals. It has been suggested that sensory optimization to match these higher order correlations (HOC) occurs at the earliest visual stages, and that photoreceptors can process temporal natural signals more efficiently than random signals. We tested this early-stage hypothesis by comparing the information content of Calliphora vicina photoreceptor responses to naturalistic inputs before and after removing HOC by randomizing phase. Forty different, 60-s long, naturalistic sequences (NS) were used, together with randomized-phase versions of the same sequences to give pink noise (PN) so that each input pair had identical means, variances, mean contrasts, and power spectra. We measured the information content of inputs and membrane potential responses by three different methods: coherence, mutual information, and compression entropy. We also used entropy and phase statistics of each pair as measures of HOC. Responses to randomized signals generally had higher gain, signal-to-noise ratio, and information rates than responses to NS. Information rate increased with a strong, positive, linear correlation to phase randomization within sequence pairs. This was confirmed by varying the degree of phase randomization. Our data indicate that individual photoreceptors encode input information by Weber’s law, with HOC within natural sequences reducing information transfer by decreasing the number of local contrast events that exceed the noise-imposed threshold. NEW & NOTEWORTHY Natural visual scenes feature statistical regularities, or higher order correlations (HOC), both in time and space, to encode surfaces, textures, and object boundaries. Visual systems rely on this information; however, it remains controversial whether individual photoreceptors can discriminate and enhance information encoded in HOC. Here we show that the more HOC the stimulus contains, the lower the information transfer rate of photoreceptors. We explain our findings by applying the Weber’s paradigm of differential signal perception.
Relative burst amplitude of muscle sympathetic nerve activity is an indicator of altered sympathetic outflow in chronic anxiety
Authors: Holwerda Seth W. , Luehrs Rachel E. , Gremaud Allene L. , Wooldridge Nealy A. , Stroud Amy K. , Fiedorowicz Jess G. , Abboud Francois M. , Pierce Gary L. 
Published: March 2018

Relative burst amplitude of muscle sympathetic nerve activity (MSNA) is an indicator of augmented sympathetic outflow and contributes to greater vasoconstrictor responses. Evidence suggests anxiety-induced augmentation of relative MSNA burst amplitude in patients with panic disorder; thus we hypothesized that acute stress would result in augmented relative MSNA burst amplitude and vasoconstriction in individuals with chronic anxiety. Eighteen participants with chronic anxiety (ANX; 8 men, 10 women, 32 ± 2 yr) and 18 healthy control subjects with low or no anxiety (CON; 8 men, 10 women, 39 ± 3 yr) were studied. Baseline MSNA and 24-h blood pressure were similar between ANX and CON ( P > 0.05); however, nocturnal systolic blood pressure % dipping was blunted among ANX ( P = 0.02). Relative MSNA burst amplitude was significantly greater among ANX compared with CON immediately preceding (anticipation) and during physiological stress [2-min cold pressor test; ANX: 73 ± 5 vs. CON: 59 ± 3% arbitrary units (AU), P = 0.03] and mental stress (4-min mental arithmetic; ANX: 65 ± 3 vs. CON: 54 ± 3% AU, P = 0.02). Increases in MSNA burst frequency, incidence, and total activity in response to stress were not augmented among ANX compared with CON ( P > 0.05), and reduction in brachial artery conductance during cold stress was similar between ANX and CON ( P = 0.92). Relative MSNA burst amplitude during mental stress was strongly correlated with state ( P < 0.01) and trait ( P = 0.01) anxiety (State-Trait Anxiety Inventory), independent of age, sex, and body mass index. Thus in response to acute stress, both mental and physiological, individuals with chronic anxiety demonstrate selective augmentation in relative MSNA burst amplitude, indicating enhanced sympathetic drive in a population with higher risk for cardiovascular disease. NEW & NOTEWORTHY Relative burst amplitude of muscle sympathetic nerve activity in response to acute mental and physiological stress is selectively augmented in individuals with chronic anxiety, which is a prevalent condition that is associated with the development of cardiovascular disease. Augmented sympathetic burst amplitude occurs with chronic anxiety in the absence of common comorbidities. These findings provide important insight into the relation between anxiety, acute stress and sympathetic activation.
Contribution from motor unit firing adaptations and muscle coactivation during fatigue
Authors: Contessa Paola , Letizi John , De Luca Gianluca , Kline Joshua C. 
Published: March 2018

The control of motor unit firing behavior during fatigue is still debated in the literature. Most studies agree that the central nervous system increases the excitation to the motoneuron pool to compensate for decreased force contributions of individual motor units and sustain muscle force output during fatigue. However, some studies claim that motor units may decrease their firing rates despite increased excitation, contradicting the direct relationship between firing rates and excitation that governs the voluntary control of motor units. To investigate whether the control of motor units in fact changes with fatigue, we measured motor unit firing behavior during repeated contractions of the first dorsal interosseous (FDI) muscle while concurrently monitoring the activation of surrounding muscles, including the flexor carpi radialis, extensor carpi radialis, and pronator teres. Across all subjects, we observed an overall increase in FDI activation and motor unit firing rates by the end of the fatigue task. However, in some subjects we observed increases in FDI activation and motor unit firing rates only during the initial phase of the fatigue task, followed by subsequent decreases during the late phase of the fatigue task while the coactivation of surrounding muscles increased. These findings indicate that the strategy for sustaining force output may occasionally change, leading to increases in the relative activation of surrounding muscles while the excitation to the fatiguing muscle decreases. Importantly, irrespective of changes in the strategy for sustaining force output, the control properties regulating motor unit firing behavior remain unchanged during fatigue. NEW & NOTEWORTHY This work addresses sources of debate surrounding the manner in which motor unit firing behavior is controlled during fatigue. We found that decreases in the motor unit firing rates of the fatiguing muscle may occasionally be observed when the contribution of coactive muscles increases. Despite changes in the strategy employed to sustain the force output, the underlying control properties regulating motor unit firing behavior remain unchanged during muscle fatigue.
Comparative Study of the Initial Experience in Performing Robotic and Laparoscopic Right Hepatectomy with Technical Description of the Robotic Technique
Authors: Marino Marco Vito , Shabat Galyna , Guarrasi Domenico , Gulotta Gaspare , Komorowski Andrzej Lech 
Published: March 2018

<b><i>Background:</i></b> Despite potential benefits of robotic liver surgery, it is still considered a “development in progress” technique. <b><i>Methods:</i></b> The outcomes of 14 patients undergoing robotic right hepatectomy were analyzed and compared with the results of 20 laparoscopic right hepatectomies consecutively performed by the same young surgeon. <b><i>Results:</i></b> The overall mean operative time was less in robotic arm (425 ± 139 vs. 565.18 ± 183.73, <i>p</i> = 0.022) and the estimated blood loss was similar (335.15 ± 139.8 vs. 423.95 ± 205.15, <i>p</i> = 0.17); no blood transfusion was required. Two patients in robotic group and 5 in laparoscopic group (<i>p</i> = 0.454) underwent conversion to open surgery; the overall morbidity was 21.4 and 15% in studied arms, respectively (<i>p</i> = 0.634). Pathology reports showed a mean surgical margin of 26.02 ± 3.9 in robotic arm, 28.76 ± 4.6 for laparoscopic, (<i>p</i> = 0.079) and we achieved a R0 resection rate of 91.66 and 85%, respectively. Reoperation and 90-days mortality rate were both null in robotic arm. One patient in laparoscopic group was reoperated due to postoperative hemorrhage. One-year overall and disease free-survival rate were 92.3 and 84.6%, respectively in robotic arm and 90 and 85% in laparoscopic arm. <b><i>Conclusions:</i></b> Robotic right hepatectomy is a safe and feasible technique providing promising short-term outcomes and oncological results also in the initial phase of learning curve.
Left Septal Slow Pathway Ablation for Atrioventricular Nodal Reentrant Tachycardia
Authors: Katritsis Demosthenes G. , John Roy M. , Latchamsetty Rakesh , Muthalaly Rahul G. , Zografos Theodoros , Katritsis George D. , Stevenson William G. , Efimov Igor R. , Morady Fred 
Published: March 2018

Background:
Immunohistochemistry studies suggest that the anatomic substrate of the slow pathway in atrioventricular nodal reentrant tachycardia (AVNRT) is the left inferior nodal extension. We hypothesized that slow pathway ablation from the left septum is an effective alternative to right-sided ablation.

Methods and Results:

We analyzed our databases of AVNRT in search of cases that had used slow pathway ablation from the left septum because of failure of right septal ablation, and then prospectively subjected consenting patients to a left septal–only procedure. Of 1342 patients subjected to right septal slow pathway ablation for AVNRT, 15 patients, 11 with typical and 4 with atypical AVNRT, had a left septal approach after unsuccessful right-sided ablation (R+L group). Eleven patients were subjected to a left septal–only approach for slow pathway ablation without a previous right septal attempt (L group). Fluoroscopy times in the R+L and L groups were 30.5 (21.0–44.0) and 20.0 (17.0–25.0) minutes, respectively (
P
=0.061), and radiofrequency current delivery times were 11.3 (5.0–19.1) and 10.0 (7.0–12.0) minutes, respectively (
P
=0.897). There was no need for additional ablation lesions at other anatomic sites in either group, and no cases of atrioventricular block were encountered. Recurrence rates of the arrhythmia for the R+L and L groups were 6.7% and 0%, respectively, in the 3 months after ablation (
P
=1.000).

Conclusions:
Left septal ablation at the anatomic site of the left inferior nodal extension is an alternative for ablation of both typical and atypical AVNRT when ablation at the right posterior septum is ineffective.
Arthur Danto, the End of Art, and the Philosophical View of History
Authors: van den Akker Chiel 
Published: March 2018

Abstract
This essay takes Arthur Danto’s end-of-art thesis as a case in point of a substantive philosophy of history. Such philosophy explains the direction that art has taken and why that direction could not have been different. Danto never scrutinized the philosophy of history that his end-of-art thesis presumes. I aim to do that by drawing a distinction between what I refer to as the common view of history and the philosophical view of history, and by arguing that we need the latter if we want to properly assess the plausibility of the end-of-art thesis.
Learning from History
Authors: Bouton Christophe 
Published: March 2018

Abstract
In this paper, I would like to show that Koselleck’s thesis on the dissolution of the topos historia magistra vitae in modernity is open to certain objections, to the extent that one finds in modernity a number of practical conceptions of history which are “useful for life”. My own thesis is that the topos of history as the “Guide to Life” is not so much dissolved as rather transformed with modernity, and in a sense which has to be specified. This point of view will be defended with reference to European authors of the nineteenth century (I focus on the examples of Droysen and Nietzsche), though I will add some observations on the twentieth century in the last part of the paper.
Predicting Near-Term Changes in the Earth System: A Large Ensemble of Initialized Decadal Prediction Simulations Using the Community Earth System Model
Authors: Yeager S. G. , Danabasoglu G. , Rosenbloom N. A. , Strand W. , Bates S. C. , Meehl G. A. , Karspeck A. R. , Lindsay K. , Long M. C. , Teng H. , Lovenduski N. S. 
Published: March 2018

AbstractThe objective of near-term climate prediction is to improve our fore-knowledge, from years to a decade or more in advance, of impactful climate changes that can in general be attributed to a combination of internal and externally forced variability. Predictions initialized using observations of past climate states are tested by comparing their ability to reproduce past climate evolution with that of uninitialized simulations in which the same radiative forcings are applied. A new set of decadal prediction (DP) simulations has recently been completed using the Community Earth System Model (CESM) and is now available to the community. This new large-ensemble (LE) set (CESM-DPLE) is composed of historical simulations that are integrated forward for 10 years following initialization on 1 November of each year between 1954 and 2015. CESM-DPLE represents the “initialized” counterpart to the widely studied CESM Large Ensemble (CESM-LE); both simulation sets have 40-member ensembles, and they use identical model code and radiative forcings. Comparing CESM-DPLE to CESM-LE highlights the impacts of initialization on prediction skill and indicates that robust assessment and interpretation of DP skill may require much larger ensembles than current protocols recommend. CESM-DPLE exhibits significant and potentially useful prediction skill for a wide range of fields, regions, and time scales, and it shows widespread improvement over simpler benchmark forecasts as well as over a previous initialized system that was submitted to phase 5 of the Coupled Model Intercomparison Project (CMIP5). The new DP system offers new capabilities that will be of interest to a broad community pursuing Earth system prediction research.