bluuebunny/crossref_metadata_2025_split huggingface dataset:
BRAND SWITCHING MODEL AGAINST CONSUMER DISSATISFACTION ON THE SHOPEE MARKETPLACE TO OTHER MARKETPLACES
Authors: Savitri Citra , Maemunah Mumun 
Published: November 2024

The study determines consumer dissatisfaction, variety seeking, and brand switching at Shopee's market offices. This study was conducted to determine the direct and indirect effects of consumer dissatisfaction and variety-seeking on brand switching on the Shopee marketplace to other marketplaces. The method used is quantitative with a population of Shopee users in Karawang who have switched to other marketplaces. A total of 150 samples were taken using a non-probability method of incidental sampling technique. In this paper, Consumer dissatisfaction has a positive and meaningful impact on variety seeking, variety seeking has a positive and significant effect on brand switching, consumer dissatisfaction has no significant and positive effect on brand switching, and consumer dissatisfaction has a significant and significant effect on brand switching through variety seeking.
El tránsito de la “ropa de China” hacia la Ciudad de México durante las primeras décadas del siglo XVIII
Authors: Mondragon Parra Jocelyn Anaid 
Published: November 2024

Durante la época colonial los textiles asiáticos como el algodón y la seda fueron muy apetecidosen América. La ropa que era confeccionada con diversas variedades de telas asiáticas pero que pertenecían a la tradición occidental fue llamada genéricamente “ropa de China”. Este nombre es abordado en el presente ensayo como una categoría con dos significados no excluyentes. Por un lado, estas “prendas chinas” eran elaboradas en Asia y posteriormente transportadas a Nueva España a través de la ruta transpacífica. Por otro lado, la tela asiática se manufacturaba por sastres novohispanos y esta ropa era vendida dentro del virreinato y hacia el sur del continente. En este texto se vierten reflexiones en torno a la comercialización de la “ropa de China” en la Ciudad de México durante el siglo XVIII a través de pleitos comerciales.
Dynamics of CO2 fluxes and environmental responses in a Poplar plantation
Authors: Ge Mengyu , Wang Weifeng , Ruan Honghua , Wang Guobing , Zhang Shuang , Yu Shuiqiang 
Published: November 2024

Forest plantations cover a large percentage of global forest landscapes contributing significantly to carbon sequestration. By using continuous eddy covariance technique, we observed net ecosystem CO2 exchange (NEE), gross primary production (GPP), ecosystem respiration (ER), and meteorological variables from August 2018 to December 2019 in a Poplar plantation. The Poplar plantation ecosystem was a carbon sink overall, with high carbon uptake in growing season and limited uptake/emission in non-growing season. The annual cumulative NEE, GEP, and ER were −763.61, 1542.19, and 778.58 g C m−2 yr−1, respectively. Photosynthetically active radiation (PAR) significantly influenced NEE both at half-hourly and daily scale (P &lt; 0.01 for both), while relative humidity (RH) and vapor pressure deficit (VPD) only significantly affected NEE at half-hourly scale (P &lt; 0.01). The prevailing wind direction throughout 2019 was southeast and it varied between seasons. Southeast wind was the prevailing wind direction in summer and winter, while southwest and northeast wind were the dominant wind direction in spring and autumn, respectively. Our results highlight that polar plantations play an important role in storing carbon, and that understanding meteorological conditions is crucial in investigating ecosystem-atmosphere interactions and their impacts on carbon cycling.
Distinct types of VHHs in Alpaca
Authors: Wang Xinhao , Zhang Lu , Zhang Yao , Li Jiaguo , Xu Wenfeng , Zhu Weimin 
Published: November 2024

IntroductionVHHs (VH of heavy-chain-only antibodies) represent a unique alternative to Q7 conventional
antibodies because of their smaller size, comparable binding affinity and biophysical properties. MethodIn this study, we systematically analyzed VHH NGS sequences from 22 Alpacas and structure data from public database. ResultsVHHs in Alpaca can be grouped into five main types with multiple distinct sequence and structure
features. Based on the existence of hallmark residues in FR2 region, VHHs can be classified into two
groups: nonclassical VHHs (without hallmark residues) and classical VHHs (with hallmark residues).
Based on VHH hallmark residues at 42 position (IMGT numbering, FR2 region) and number of cysteines,
we found that Alpaca classical VHHs can be further separated into three main types: F_C2 VHHs with F
(phenylalanine) at position 42 and having 2 cysteines within sequences, Y_C2 VHHs with Y (tyrosine)
at position 42 and having 2 cysteines, and F_C4 with F at position 42 and having 4 cysteines. Non-classical VHHs can be further separated into 2 types based on germlines mapped: N_V3 for VHHs mapped to V3 germlines and N_V4 for V4 germlines. Based on whether FR2 residues are involved in binding, two kinds of paratopes can be identified. Different types of VHHs showed distinct associations with these two paratopes and displayed significant differences in paratope size, residue usage and other structure features. DiscussionSuch results will have significant implications in VHH discovery, engine e ring, and design for innovative therapeutics.
Effects of repetitive transcranial magnetic stimulation combined with repetitive peripheral magnetic stimulation on upper limb motor function after stroke: a systematic review and meta-analysis
Authors: Luo Shanshan , Wen Zhu , Liu Ying , Sun Tao , Xu Li , Yu Qian 
Published: November 2024

ObjectiveTo evaluate the effectiveness of repetitive transcranial magnetic stimulation (rTMS) combined with repetitive peripheral magnetic stimulation (rPMS) on upper limb motor dysfunction after stroke.MethodsWe systematically searched databases up to May 2024, including PubMed, Embase, Cochrane Library, Web of Science, CNKI, VIP, Wanfang, and CBM. Randomized controlled trials (RCTs) examining the application of rTMS combined rPMS on upper limb motor dysfunction after stroke were included based on predefined inclusion criteria. We used Cochrane Risk of Bias 2 tool to assess bias risk of the included RCTs. Meta-analysis was conducted using RevMan 5.4 and Stata 17.0 software.ResultsA total of 9 RCTs involving 483 participants were included in this study. Compared with the control groups that used either conventional therapy or rTMS alone, the experimental group that used rTMS combined rPMS showed significant improvements in stroke patients' upper limb motor function [MD = 3.65, 95% CI (2.75, 4.54), P &lt; 0.05], ability of daily living [MD = 4.50, 95% CI (3.50, 5.50), P &lt; 0.05], and spasticity [MD = –0.34, 95% CI (−0.48, −0.20), P &lt; 0.05]. Meanwhile, in terms of neurophysiological indicators, significant differences were found both for motor evoked potential latency [MD = −1.77, 95% CI (−3.19, −0.35), P &lt; 0.05] and motor evoked potential amplitude [MD = 0.25, 95% CI (0.01, 0.49), P &lt; 0.05].ConclusionThis study provides low-level evidence that the therapy of LF-rTMS or HF-rTMS combined with rPMS can improve the upper limb motor function and daily living ability of stroke patients. However, given that the low quality of the evidence for the evaluation results, further evidence from high-quality studies is needed to substantiate this conclusion.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42024539195, PROSPERO Platform [CRD42024539195].
Pneumatization pattern of the temporal bone with volumetric assessment and its impact on the frequency of cerebrospinal fluid leak in patients undergoing vestibular schwannoma surgery via the retrosigmoid approach
Authors: Zaczkowski Karol , Wójcik Rafał , Tybor Krzysztof , Jaskólski Dariusz Jan , Wiśniewski Karol 
Published: November 2024

IntroductionVestibular schwannomas are benign tumors that account for 8% of all intracranial tumors. Due to their location in the cerebellopontine angle and internal auditory canal, access to these lesions requires disruption of the temporal bone. The pneumatization of this bone varies between individuals, and literature reports suggest that it may influence the frequency of cerebrospinal fluid leaks. In our study, we assessed whether the pneumatization of the temporal bone differs in individuals with or without cerebrospinal fluid leak.MethodsWe conducted a retrospective analysis that initially included 143 individuals, of whom 103 were ultimately qualified for the study. We analyzed the clinical data of the patients and the radiological characteristics of the pneumatization of the temporal bone using volumetric methods, additionally relying on classifications of temporal bone pneumatization.ResultsPneumatization of the temporal bone in patients operated on for vestibular schwannoma with cerebrospinal fluid leakage was significantly higher compared to the group without leakage (Right: 11.15 [IQR 8.93–12.83] vs. 13.25 [IQR 10.15–15.53]; p = 0.040; Left: 10.95 [IQR 9.5–12.26] vs. 14.4 [IQR 13.03–15.7]; p = 0.012). Additionally, a higher degree of pneumatization of the petrous apex was significantly more frequent in the group with cerebrospinal fluid leak in both left (p &lt; 0.001) and right (p &lt; 0.001) side.DiscussionThe analyzed data suggest that greater pneumatization of the temporal bone and a higher degree of petrous apex pneumatization in the classification of temporal bone pneumatization may be associated with an increased risk of cerebrospinal fluid leak. To draw causal inferences, prospective studies in this area are necessary.
Cytokine correlations in childhood-onset rheumatic diseases with pulmonary involvement
Authors: Huang Hua , Ding Fei , Liu Chenxi , Bao Shengfang , Jin Yingying , Jin Yanliang , Bao Yixiao 
Published: November 2024

BackgroundThere was less research about cytokines in lung involvement of childhood-onset rheumatic diseases (RD) patients.ObjectiveIn this investigation, blood levels of 12 cytokines were tested in order to explore their associations with lung involvement in newly diagnosed childhood-onset RD patients.MethodsHigh-resolution computed tomography (HRCT) and pulmonary function tests (PFTs) were performed on 53 newly diagnosed RD patients without any treatment in our department between July 2021 and December 2023. Patients were separated into groups based on whether their lungs were involved or not according to abnormalities found on HRCT or PFTs. We examined the serum cytokines with 41 healthy, age and gender-matched controls.ResultsThe majority of serum cytokine levels were statistically different between the RD group with lung involvement and the control group. The RD group with lung involvement had considerably higher serum IL-6 and IFN-γ levels than the RD group without lung involvement or control group. The median serum IL-6 levels were 19 pg/ml [interquartile range (IQR) 6.9, 27.6], 4.4 pg/ml (IQR 2.0, 10.5), and 2.0 pg/ml (IQR 2.0, 2.0) in RD group with lung involvement, RD group without lung involvement, and control group, respectively. Similarly, the median serum IFN-γ levels were 6.0 pg/ml (IQR 5.0, 15), 5.0 pg/ml (IQR 5.0, 5.0), and 5.0 pg/ml (IQR 5.0, 5.0) in RD group with lung involvement, RD group without lung involvement, and control group, respectively. The receiver operating characteristic (ROC) curve study showed that IL-6 and IFN-γ had area under the curve (AUC) values of 0.782 and 0.742, respectively, indicating their significant diagnostic potential for lung involvement in RD patients.ConclusionOur findings imply that IL-6 and IFN-γ may be associated with the development of lung illnesses and may be involved in the pathophysiology of RD. Thus, in individuals with RD, elevated levels of IFN-γ over 5.42 pg/ml or IL-6 above 6.25 pg/ml may warrant suspicion of lung involvement.
Salidroside ameliorates cerebral ischemic injury and regulates the glutamate metabolism pathway in astrocytes
Authors: Zheng Xiaoyu , Zhang Hongwei , Zhang Yehao , Ding Zhao , Huang Zishan , Li Haoran , Yao Mingjiang , Song Wenting , Liu Jianxun 
Published: November 2024

Background and AimSalidroside (SA) is the main active component of Rhodiola rosea L., with potential in treating cardiovascular and cerebrovascular diseases and cerebral ischemia. However, its efficacy and mechanism in cerebral ischemia remain unclear, particularly regarding its effect on glutamate (Glu) metabolism. In this paper, we aimed to investigate the efficacy of SA in treating cerebral ischemia and its pharmacological mechanism.Experimental procedureWe studied the effects of SA on SD rats with cerebral ischemia, evaluating neurobehavior, cerebral water content, infarct size, and brain microstructure. We also assessed its impact on glial fibrillary acidic protein (GFAP), glutamine synthetase (GS), and glutamate transporter 1 (GLT-1) proteins using immunohistochemistry and Western blot. Additionally, we used SVGp12 cells to simulate cerebral ischemia and measured Glu levels and used Western blot to observe the level of GS and GLT-1.ResultsSA improved neural function, reduced infarct size, and regulated GSH and Glu levels in rats. In cell experiments, SA increased cell viability and decreased Glu concentration after ischemia induction. It also regulated the expression of GFAP, GS, and GLT-1.ConclusionSA alleviates cerebral ischemia-induced injury by acting on astrocytes, possibly through regulating the glutamate metabolic pathway.
Limitations of soil-applied non-microbial and microbial biostimulants in enhancing soil P turnover and recycled P fertilizer utilization - a study with and without plants
Authors: Herrmann Michelle Natalie , Griffin Lydia Grace , John Rebecca , Mosquera-Rodríguez Sergio F. , Nkebiwe Peteh Mehdi , Chen Xinping , Yang Huaiyu , Müller Torsten 
Published: November 2024

IntroductionPhosphorus recovery from waste streams is a global concern due to open nutrient cycles. However, the reliability and efficiency of recycled P fertilizers are often low. Biostimulants (BS), as a potential enhancer of P availability in soil, could help to overcome current barriers using recycled P fertilizers. For this, a deeper understanding of the influence of BSs on soil P turnover and the interaction of BSs with plants is needed. MethodsWe conducted an incubation and a pot trial with maize in which we testednon-microbial (humic acids and plant extracts) and microbial BSs (microbial consortia) in combination with two recycled fertilizers for their impact on soil P turnover, plant available P, and plant growth.Results and discussionBSs could not stimulate P turnover processes (phosphatase activity, microbial biomass P) and had a minor impact on calcium acetate-lactate extractable P (CAL-P) in the incubation trial. Even though stimulation of microbial P turnover by the microbial consortium and humic acids in combination with the sewage sludge ash could be identified in the plant trial with maize, this was not reflected in the plant performance and soil P turnover processes. Concerning the recycled P fertilizers, the CAL-P content in soil was not a reliable predictor of plant performance with both products resulting in competitive plant growth and P uptake. While this study questions the reliability of BSs, it also highlights the necessity toimprove our understanding and distinguish the mechanisms of P mobilization in soil and the stimulation of plant P acquisition to optimize future usage.
Augmenting self-guided virtual-reality exposure therapy for social anxiety with biofeedback: a randomised controlled trial
Authors: Premkumar Preethi , Heym Nadja , Myers James A. C. , Formby Phoebe , Battersby Steven , Sumich Alexander Luke , Brown David Joseph 
Published: November 2024

IntroductionWe previously found that self-guided Virtual Reality Exposure Therapy (VRET) improved Public Speaking Anxiety (PSA) and reduced heartrate. Elevated heartrate characterises social anxiety and the self-guided VRET seemed to reduce heartrate. Thus, receiving continuous biofeedback about physiological arousal during the VRET could help socially anxious individuals to manage their anxiety. The present study aimed to determine whether biofeedback enhances the responsiveness of VRET.MethodsSeventy-two individuals with high self-reported social anxiety were randomly allocated to VRET-plus-biofeedback (n=38; 25 completers) or VRET alone (n=35; 25 completers). Three hour-long VRET sessions were delivered over three consecutive weeks. During each session, participants delivered a 20-minute public speech in front of a virtual audience. Participants in the VRET-plus-biofeedback group received biofeedback on heartrate and frontal alpha asymmetry (FAA) within the virtual environment and were asked to lower their arousal accordingly. Participants in both groups completed psychometric assessments of social anxiety after each session and at one-month follow-up.ResultsPSA improved by the end of treatment and overall social anxiety improved one month after the VRET across both groups. The VRET-plus-biofeedback group showed a steadier reduction in FAA in the first VRET session and a greater reduction in self-reported arousal across the three sessions than the VRET-alone group.ConclusionBiofeedback can steady physiological arousal and lower perceived arousal during exposure. The benefits of self-guided VRET for social anxiety are sustained one month after therapy.
Psychosocial, emotional and behavioral problems, quality of life, and mental health care seeking behaviors among children and adolescents in Jordan: a national school-based survey
Authors: Khader Yousef , Abu Khudair Sara , Tanaka Eizaburo , Kufoof Lara , Al Nsour Mohannad , Aqel Ashraf , Maayeh Mohammad , Kharabsha Ahmad 
Published: November 2024

ObjectivesThis study aimed to estimate the prevalence of psychosocial, emotional, and behavioral problems and their symptoms among children and adolescents in Jordan, assess their quality of life, and examine mental health help-seeking behavior.MethodsA large-scale school-based national survey was conducted in Jordan among children and adolescents aged 8 to 18 years (grades 3 to 12) from the host and refugee populations, utilizing a multi-stage stratified cluster sampling technique to select a nationally representative sample. Two versions of structured questionnaires were used: proxy parent version for students in grades 3 to 6 (8–11 years) and self-report version for students in grades 7 to 12 (12–18 years). The study questionnaires employed internationally recognized and validated tools in English, which were translated into Arabic.ResultsA total of 8,000 (3,433 (42.9%) boys, 4,567 (57.1%) girls) and (3,593 (44.9%) children, 4,407 (55.1%) adolescents) were included. About 24.5% of children had anxiety symptoms (18.0% of Jordanians, 34.5% of Syrian camp refugees, 33.7% of Syrian urban refugees, and 24.7% of Palestinian camp refugees) and 16.6% of children had major depressive disorder symptoms (11.0% of Jordanians, 25.4% of Syrian camp refugees, 25.0% of Syrian urban refugees, and 14.0% of Palestinian camp refugees). Almost 13.9% of children and 19.7% of adolescents had abnormal levels of total emotional and behavioral difficulties. Nearly 16.5% of children and 35.0% of adolescents had poor overall health-related quality of life. When experiencing a personal or emotional problem, only 28.1% of children’s parents would seek help for their children and 19.7% of adolescents would seek help for themselves.ConclusionThe study revealed a high prevalence of various mental health issues’ symptoms, particularly among refugees and female adolescents. Intention to seek help is relatively low, suggesting that children and adolescents’ mental health needs are not being widely met. It is crucial to implement integrated and coordinated plans and programs that effectively target multiple factors that impact children and adolescents’ mental health, while also respecting the prevailing cultural context. A key aspect of promoting the mental well-being of children and adolescents in Jordan is the inclusive involvement of refugees and individuals from other nationalities.
Mental and physical health characteristics of older and younger adults receiving medication for opioid use disorder
Authors: Walker Teresa J. , Mohankumar Rakshitha , Kraus Shane W. , Cotton Brandi P. , Renn Brenna N. 
Published: November 2024

BackgroundMethadone is an effective and widely used medication for opioid use disorder (MOUD). Within in the United States (US), older adults represent an increasing proportion of those receiving MOUD, yet little is known about characteristics of older individuals in these programs.ObjectivesTo evaluate mental and physical health characteristics of younger and older adults receiving MOUD and test whether age moderates the relation between physical and mental health variables.MethodsData for this secondary analysis are drawn from a cross-sectional survey of a convenience sample of individuals seeking methadone dosing as part of MOUD at four opioid treatment programs in two regions of the US. Descriptive statistics and correlational and moderation analyses examined outcomes of pain severity, pain interference, self-rated health, physical activity, depression, and anxiety across younger (18-49) and older (50+ years) participants.ResultsAnalyses included 469 participants (mean [range] age, 41.01 [20–70] years). Older participants reported higher pain severity and interference, less physical activity, and worse self-rated health than those in the younger age group (ps &lt; 0.05). Associations between mental and physical health variables were generally weak-to-moderate in the older age group (r = 0.26 to r = 0.44, p &lt; 0.01), and weak in the younger age group, although age did not moderate associations.ConclusionClinically significant mental and physical health variables are associated among individuals receiving methadone for MOUD, with older adults facing unique challenges.Clinical implicationsOpioid use treatment should include not only pain management but also assessment and treatment of depression and anxiety and optimization of other health behaviors (e.g., physical activity) across age groups. Pain management and health promotion are particularly relevant targets for aging individuals receiving MOUD.
Perceived Effectiveness of Public Health Unit Partnerships With Faith-Based and Other Community-Based Organizations to Promote COVID-19 Vaccination Among Ethnoracial Communities
Authors: Song Melodie Yunju , Blake-Hepburn Denessia , Varia Monali , Estey Noad Elizabeth , Peer Nazia , Pakes Barry , Fadel Shaza A. , Allin Sara , Ataullahjan Anushka , Di Ruggiero Erica 
Published: November 2024

ObjectivesThe objective of this study was to explore how Ontario Public Health Units (PHUs) partnered with faith-based organizations (FBOs) and other community-based organizations (CBOs) to promote COVID-19 vaccination among ethnoracial groups made structurally vulnerable during the pandemic, and to understand how PHUs perceive the effectiveness of these partnerships with these organizations.MethodsBetween June to December 2022, we distributed a cross-sectional survey to 34 PHUs in Ontario to explore how PHUs were engaging and partnering with FBOs and CBOs.ResultsResponses were received from 28 of 34 (82.5%) public health units. Across Ontario, 23 (82.1%) respondent PHUs worked with FBOs during the COVID-19 vaccine rollout with activities ranging from informing FBOs of vaccine availability, to using places of worship as sites for vaccine administration and co-creating educational materials on immunization that were faith- and culturally sensitive.ConclusionFBOs can be a valuable community partner as PHUs work to increase the reach and uptake of public health interventions. Ongoing monitoring and evaluation of the impact of FBO engagement on vaccine confidence and uptake among ethnoracial communities is needed to inform future community engaged vaccine programming in Ontario.