bluuebunny/crossref_metadata_2025_split huggingface dataset:
Positive effects of low LDL-C and statins on bone mineral density: an integrated epidemiological observation analysis and Mendelian randomization study
Authors: Li Gloria Hoi-Yee , Cheung Ching-Lung , Au Philip Chun-Ming , Tan Kathryn Choon-Beng , Wong Ian Chi-Kei , Sham Pak-Chung 
Published: July 2019

Abstract

Background
Low-density lipoprotein cholesterol (LDL-C) is suggested to play a role in osteoporosis but its association with bone metabolism remains unclear. Effects of LDL-C-lowering drugs on bone are also controversial. We aim to determine whether LDL-C is linked causally to bone mineral density (BMD) and assess the effects of LDL-C-lowering drugs on BMD.

Methods
Association between blood lipid levels and BMD was examined by epidemiological observation analyses in a US representative cohort NHANES III (n = 3638) and the Hong Kong Osteoporosis Study (HKOS; n = 1128). Two-sample Mendelian randomization (MR), employing genetic data from a large-scale genome-wide association study (GWAS) of blood lipids (n = 188 577), total body BMD (TB-BMD) (n = 66 628) and estimated BMD (eBMD) (n= 142 487), was performed to infer causality between LDL-C and BMD. Genetic proxies for LDL-C-lowering drugs were used to examine the drugs’ effects on BMD.

Results
In the NHANES III cohort, each standard deviation (SD) decrease in LDL-C was associated with a 0.045 SD increase in femoral neck BMD (95% CI: 0.009 − 0.081; P = 0.015). A similar increase in BMD was observed in the HKOS at femoral neck and lumbar spine. In MR analysis, a decrease in genetically predicted LDL-C was associated with an increase in TB-BMD {estimate per SD decrease, 0.038 [95% confidence interval (CI): 0.002 − 0.074]; P = 0.038} and eBMD [0.076 (0.042 − 0.111); P = 1.20x10−5]. Reduction in TB-BMD was causally associated with increased LDL-C [0.035 (0.033 − 0.066); P = 0.034]. Statins’ LDL-C-lowering proxies were associated with increased TB-BMD [0.18 (0.044 − 0.316); P = 9.600x10−3] and eBMD [0.143 (0.062 − 0.223); P = 5.165x10−4].

Conclusions
Negative causal association exists between LDL-C level and BMD. Statins’ LDL-C-lowering effect increases BMD, suggesting their protective effect on bone.
Even Today, a Western and Gendered Social Science: Persistent Geographic and Gender Biases in Undergraduate IR Teaching
Authors: Knight Sarah Cleeland 
Published: July 2019

Abstract
A perennial critique of international relations is that the field focuses disproportionately on the United States and Europe and contains a gender bias in terms of ignoring issues of particular concern to women. The field is also infamous for how difficult it is for female scholars to publish and have their publications cited. This study evaluates these claims of bias in the area of undergraduate international relations teaching by analyzing an original dataset of 48 introduction to international relations syllabi from ten countries. The study analyzes the authors of required readings and the theories and empirical topics taught, and finds that the geographic and gender biases are both firmly in place. The first finding is that courses assign readings predominantly from US-resident, US-trained, male authors, even those courses taught outside the United States and those taught by female faculty. A second finding is that assigned readings focus overwhelmingly on the United States more than any other country or region, and only 1 percent of readings focus specifically on gender-related issues.
Insights on Funeral Practices and Insects Associated With the Tombs of King Ferrante II d’Aragona and Other Renaissance Nobles
Authors: Loni Augusto , Fornaciari Antonio , Canale Angelo , Giuffra Valentina , Vanin Stefano , Benelli Giovanni 
Published: July 2019

Abstract
The impressive Sacristy of the Basilica of San Domenico Maggiore contains 38 wooden sarcophagi with the bodies of 10 Aragonese princes and other Neapolitan nobles, who died in the 15th and 16th centuries. To improve the knowledge about the entomofauna associated with bodies in archaeological contexts, herein we provide insights on the funerary practices and the insect community associated to Ferrante II King of Naples and other Italian Renaissance mummies of the Aragonese dynasty buried in the Basilica of St. Domenico Maggiore. We identified 842 insect specimens: 88% were Diptera (Muscidae, Fanniidae, and Phoridae), followed by 9% Lepidoptera (Tineidae) and 3% Coleoptera (Dermestidae and Ptinidae). Ninety-seven percent of the specimens were collected from the coffin of Francesco Ferdinando d’Avalos, which was the best preserved. A lack of fly species characterizing the first colonization waves of exposed bodies was noted. The most common fly was the later colonizing muscid Hydrotaea capensis (Wiedemann); only a few Fanniidae (Fannia spp.) were retrieved. The lack of blowflies, coupled with recording H. capensis as the dominant fly, supports our hypothesis that corpses have been kept indoors for a long time under confined environmental conditions. Other explanations include odorous oils/balms having been used in the embalming process, causing the delay or stopping the arrival of first colonizer flies. Hermetically sealing of the coffin with bitumen may also have played a role in preventing access to the corpses. This scenario describes a historical context characterized by a well-advanced knowledge of body preparation, with specific burial techniques adopted for nobles.
Elastic fiber system evaluated in the digestive organ of rats
Authors: Inoue Kouji , Kuroda Noriyuki , Sato Tetsuji 
Published: July 2019

AbstractAccording to our previous reports, the intraperiodontal elastic fiber system comprises oxytalan fibers, whereas all types of elastic system fibers are present in the gingiva. Much remains to be elucidated regarding the topographic development of the elastic fiber system that constitutes the walls of the digestive organs. This study aimed to examine the topographic development of the elastic fiber system in the periodontal tissue, oral cavity and digestive tract of rats at light- and electron microscopic levels. At embryonic day 20, in situ hybridization revealed the mRNA expression of tropoelastin in the putative gingival lamina propria but not in the dental follicle. At the postnatal stage, the masticatory mucous membrane of the gingiva and hard palate comprised three different types of elastic system fibers (oxytalan, elaunin and elastic fibers). Conversely, the elastic fiber system comprised elaunin and elastic fibers in other oral mucosae and the lining mucosae of digestive tract organs (the esophagus, stomach and small intestine).The findings of our study suggest that the elastic fiber system is mainly related to tissue resistance in the periodontal ligament and tissue elasticity in the oral mucosae without masticatory mucosae and the overlying mucosa of digestive tracts and both functions in the gingiva and hard palate, respectively. The appearance of elaunin fibers in the periodontium of rats aged 14 weeks suggests the expression of tropoelastin induced by mechanical stressors such as mastication. The intraperiodontal difference in the distribution of elaunin fibers suggests heterogeneity among fibroblasts constituting the periodontium.
The Role of APAL/ST8SIA6-AS1 lncRNA in PLK1 Activation and Mitotic Catastrophe of Tumor Cells
Authors: Luo Man-Li , Li Jingjing , Shen Liping , Chu Junjun , Guo Qiannan , Liang Guorun , Wu Wei , Chen Jianing , Chen Rufu , Song Erwei 
Published: July 2019

Abstract

Background
Tumor growth can be addicted to vital oncogenes, but whether long noncoding RNAs (lncRNAs) are essential to cancer survival is largely uncharacterized.

Methods
We retrieved Gene Expression Omnibus datasets to identify lncRNA overexpression in 257 cancers vs 196 normal tissues and analyzed the association of ST8SIA6-AS1 (termed Aurora A/Polo-like-kinase 1 [PLK1]–associated lncRNA, APAL) with the clinical outcomes of multiple types of cancer from public RNA sequencing and microarray datasets as well as from in-house cancer cohorts. Loss- and gain-of-function experiments were performed to explore the role of APAL in cancers in vitro and in vivo. RNA pulldown and RNA immunoprecipitation were used to investigate APAL-interacting proteins. All statistical tests were two-sided.

Results
APAL is overexpressed in multiple human cancers associated with poor clinical outcome of patients. APAL knockdown causes mitotic catastrophe and massive apoptosis in human breast, lung, and pancreatic cancer cells. Overexpressing APAL accelerates cancer cell cycle progression, promotes proliferation, and inhibits chemotherapy-induced apoptosis. Mechanism studies show that APAL links up PLK1 and Aurora A to enhance Aurora A-mediated PLK1 phosphorylation. Notably, targeting APAL inhibits the growth of breast and lung cancer xenografts in vivo (MCF-7 xenografts: mean tumor weight, control = 0.18 g [SD = 0.03] vs APAL locked nucleic acids = 0.07 g [SD = 0.02], P &lt; .001, n = 8 mice per group; A549 xenografts: mean tumor weight control = 0.36 g [SD = 0.10] vs APAL locked nucleic acids = 0.10 g [SD = 0.04], P &lt; .001, n = 9 mice per group) and the survival of patient-derived breast cancer organoids in three-dimensional cultures.

Conclusions
Our data highlight the essential role of lncRNA in cancer cell survival and the potential of APAL as an attractive therapeutic target for a broad-spectrum of cancers.
Patient care without borders: a systematic review of medical and surgical tourism
Authors: Foley Brittany M , Haglin Jack M , Tanzer Joshua Ray , Eltorai Adam E M 
Published: July 2019

Abstract

Background
Medical tourism (MT) is an increasingly utilized modality for acquiring medical treatment for patients globally. This review assimilates the current literature regarding MT, with particular focus on the applications, ethics and economics.

Methods
A systematic review of MEDLINE and PubMed Central databases for publications relating to MT from 2005 to 2018 yielded 43 articles for this review.

Results
Patients seeking elective bariatric, cosmetic and orthopedic surgery abroad are motivated by significantly lower costs, all-inclusive vacation packages and reduced wait times. Complication rates as high as 56% include infection, poor aesthetic and functional outcome and adverse cardiovascular events. Cross-border reproductive care has steadily increased due to less restrictive policies in select countries; however, the depth of research on outcomes and quality of care is abysmal. Stem cell therapy promise treatments that are often not well researched and offer minimal evidence of efficacy, yet patients are drawn to treatment through anecdotal advertisements and a last sense of hope. Transplant surgery sought to decrease wait times carries many of the similar aforementioned risks and may contribute to the practice of organ trafficking in countries with high rates of poverty. Patients and countries alike are motivated by a plethora of factors to engage in the MT industry but may be doing so without accurate knowledge of the quality, safety or potential for economic gain. Safety is of utmost importance to prevent surgical complications and the spread of treatment-resistant bacteria.

Conclusions
MT is growing in popularity and complexity. The lack of standardization in its definition and regulation leads to difficulty in epidemiologic and economic analysis and ethical issues of informed consent and health equity. The findings of this review may be used by the stakeholders of MT, including patients and providers, to enhance informed decision-making and quality of care.
Ionization degree and magnetic diffusivity in the primordial star-forming clouds
Authors: Nakauchi Daisuke , Omukai Kazuyuki , Susa Hajime 
Published: July 2019

ABSTRACTMagnetic fields play such roles in star formation as the angular momentum transport in star-forming clouds, thereby controlling circumstellar disc formation and even binary star formation efficiency. The coupling between the magnetic field and gas is determined by the ionization degree in the gas. Here, we calculate the thermal and chemical evolution of the primordial gas by solving chemical reaction network where all the reactions are reversed. We find that at ∼1014–1018 cm−3, the ionization degree becomes 100–1000 times higher than the previous results due to the lithium ionization by thermal photons trapped in the cloud, which has been omitted so far. We construct the minimal chemical network which can reproduce correctly the ionization degree as well as the thermal evolution by extracting 36 reactions among 13 species. Using the obtained ionization degree, we evaluate the magnetic field diffusivity. We find that the field dissipation can be neglected for global fields coherent over ≳ a tenth of the cloud size as long as the field is not so strong as to prohibit the collapse. With magnetic fields strong enough for ambipolar diffusion heating to be significant, the magnetic pressure effects to slow down the collapse and to reduce the compressional heating become more important, and the temperature actually becomes lower than in the no-field case.
A study of gamma-ray burst afterglows as they first come into view of the SwiftUltraviolet and Optical Telescope
Authors: Page M J , Oates S R , De Pasquale M , Breeveld A A , Emery S W K , Kuin N P M , Marshall F E , Siegel M H , Roming P W A 
Published: July 2019

ABSTRACT
We examine the emission from optically bright gamma-ray burst (GRB) afterglows, as the Ultraviolet and Optical Telescope (UVOT) on the Neil Gehrels Swift Observatory first begins observing, following the slew to target the GRB, while the pointing of the Swift satellite is still settling. We verify the photometric quality of the UVOT settling data using bright stars in the field of view. In the majority of cases, we find no problems with the settling exposure photometry, but in one case, we excise the first second of the exposure to mitigate a spacecraft attitude reconstruction issue, and in a second case, we exclude the first second of the exposure in which the UVOT photocathode voltage appears to be ramping up. Of a sample of 23 afterglows which have peak V magnitudes <16, we find that all are detected in the settling exposures, when Swift arrives on target. For nine of the GRBs, the UVOT settling exposure took place before the conclusion of the prompt gamma-ray emission. Five of these GRBs have well-defined optical peaks after the settling exposures, with rises of >0.5 mag in their optical light curves, and there is a marginal trend for these GRBs to have long T90. Such a trend is expected for thick-shell afterglows, but the temporal indices of the optical rises and the timing of the optical peaks appear to rule out thick shells.
Humean Laws and (Nested) Counterfactuals
Authors: Loew Christian , Jaag Siegfried 
Published: July 2019

AbstractHumean reductionism about laws of nature is the view that the laws reduce to the total distribution of non-modal or categorical properties in spacetime. A worry about Humean reductionism is that it cannot motivate the characteristic modal resilience of laws under counterfactual suppositions and that it thus generates wrong verdicts about certain nested counterfactuals. In this paper, we defend Humean reductionism by motivating an account of the modal resilience of Humean laws that gets nested counterfactuals right.
Managerial Short-Termism and Investment: Evidence from Accelerated Option Vesting*
Authors: Ladika Tomislav , Sautner Zacharias 
Published: July 2019

AbstractWe show that executives cut investment when their incentives become more short term. We examine a unique event in which hundreds of firms eliminated option vesting periods to avoid a drop in income under accounting rule FAS 123-R. This event allowed executives to exercise options earlier and thus profit from boosting short-term performance. Our identification exploits that FAS 123-R’s adoption was staggered almost randomly by firms’ fiscal year-ends. CEOs cut investment and reported higher short-term earnings after option acceleration, and they subsequently increased equity sales.
Irritability and brain volume in adolescents: cross-sectional and longitudinal associations
Authors: Dennis Emily L , Humphreys Kathryn L , King Lucy S , Thompson Paul M , Gotlib Ian H 
Published: July 2019

Abstract
Irritability is garnering increasing attention in psychiatric research as a transdiagnostic marker of both internalizing and externalizing disorders. These disorders often emerge during adolescence, highlighting the need to examine changes in the brain and in psychological functioning during this developmental period. Adolescents were recruited for a longitudinal study examining the effects of early life stress on the development of psychopathology. The 151 adolescents (73 M/78 F, average age = 11.5 years, standard deviation = 1.1) were scanned with a T1-weighted MRI sequence and parents completed reports of adolescent irritability using the Affective Reactivity Index. Of these 151 adolescents, 94 (46 M/48 F) returned for a second session (average interval = 1.9 years, SD = 0.4). We used tensor-based morphometry to examine cross-sectional and longitudinal associations between irritability and regional brain volume. Irritability was associated with brain volume across a number of regions. More irritable individuals had larger hippocampi, insula, medial orbitofrontal cortex and cingulum/cingulate cortex and smaller putamen and internal capsule. Across the brain, more irritable individuals also had larger volume and less volume contraction in a number of areas that typically decrease in volume over the developmental period studied here, suggesting delayed maturation. These structural changes may increase adolescents’ vulnerability for internalizing and externalizing disorders.
A Needs Analysis of Parents Following Sudden Cardiac Death in the Young
Authors: McDonald Kristie , Sharpe Louise , Yeates Laura , Semsarian Christopher , Ingles Jodie 
Published: July 2019

ABSTRACTThe sudden cardiac death (SCD) of a young person is a devastating event for any parent. Inherited heart disease is often either identified or assumed to be the cause. Few studies have explored the psychosocial impact to the surviving at-risk family members. We sought to investigate the needs of parents who have experienced the SCD of their child (≤45 years). A quantitative needs analysis questionnaire was developed based on semi-structured interviews, including one focus group, and a review of relevant literature. There were 38 parents who completed a cross-sectional quantitative survey. Parents’ perceived needs for information and support spanned medical, psychosocial, spiritual and financial domains. Medical information and support needs were identified as the most important domains, followed by psychosocial, spiritual and financial information and support needs. Importantly, psychosocial information and support needs were reported as the most unmet need, endorsed by 54% of parents. Medical information and support needs were reported as unmet by almost one third of parents. The two most endorsed needs were “To have the option of whether or not you would pursue genetic testing for yourself or family members” and “To understand what happened”. This work demonstrates for the first time, the multifactorial needs of parents after SCD in the young. With the greatest unmet need reported as psychosocial needs, there is clear necessity to find ways of integrating psychological support in to the care of families after SCD in the young.KEY QUESTIONSWhat is already known about this subject?There is currently very little known about the needs of families following a sudden cardiac death due to inherited heart diseases. We know there is significant risk of poor psychological outcomes including posttraumatic stress and prolonged grief, even years after the death, however this is one of the first studies to formally evaluate the needs of parents during this time.What does this study add?We show that medical information and support needs are ranked very highly, but psychosocial support needs are the most unmet. Our findings provide a platform for developing an approach to delivering psychosocial support interventions in this population.How might this impact on clinical practice?Currently clinical and research efforts in this setting focus on clinical and genetic aspects of care. Here we show the critical need to also focus on the psychological care needs in this population. These data will help to guide services in integrating psychological support in to their multidisciplinary clinic models.
Accuracy of ECG Chest Electrode Placements by Paramedics; an observational study
Authors: Gregory Pete , Lodge Stephen , Kilner Tim , Paget Suzy 
Published: July 2019

AbstractBackgroundThe use of the 12-lead ECG is common in UK paramedic practice but its value depends upon accurate placement of the ECG-electrodes. Several studies have shown widespread variation in the placement of chest electrodes by other health professionals but no studies have addressed the accuracy of paramedics. The main objective of this study was to ascertain the accuracy of the chest lead placements by registered paramedics.MethodsRegistered paramedics who attended the Emergency Services Show in Birmingham in September 2018 were invited to participate in this observational study. Participants were asked to place the chest electrodes on a male model in accordance with their current practice. Correct positioning was determined against the Society for Cardiological Science & Technology’s Clinical Guidelines for recording a standard 12-lead electrocardiogram (2017) with a tolerance of 19mm being deemed acceptable based upon previous studies.Results52 eligible participants completed the study. Measurement of electrode placement in the craniocaudal and mediolateral planes showed a high level of inaccuracy with 3/52 (5.8%) participants able to accurately place all chest leads. In leads V1 - V3, the majority of incorrect placements were related to vertical displacement with most participants able to identify the correct horizontal position. In V4, the tendency was to place the lead too low and to the left of the pre-determined position whilst V5 tended to be below the expected positioning but in the correct horizontal alignment. There was a less defined pattern of error in V6 although vertical displacement was more likely than horizontal displacement.ConclusionsOur study identified a high level of variation in the placement of chest ECG electrodes which could alter the morphology of the ECG. From a patient safety perspective, we would advocate that paramedics leave the chest electrodes in situ to allow hospital staff to assess the accuracy of the placements.Key messagesWhat is already known on this subjectThe recording of a prehospital ECG has become increasingly common in sophisticated Emergency Medical Services across the worldThe accuracy of precordial ECG electrode placement has been studied with other health professionals and has highlighted varying degrees of accuracy.Inaccurate electrode placement can lead to aberrant ECG readings and application of unnecessary treatment or the withholding of indicated treatmentWhat this study addsIn this observational cohort study, we found significant variation in the placement of the precordial ECG electrodes by UK registered paramedicsWe recommend that paramedics leave the prehospital ECG electrodes in situ to allow hospital staff to assess the accuracy of the placements.