bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficacy and safety of Tripterygium wilfordii glycosides tablets combined with Western medicine for patients with rheumatic immune diseases
Authors: Shu Hang , Chen Xiao-Yu , Zhao Jie , Li Pin , Sun Zhen 
Published: November 2024

BACKGROUND
Rheumatic immune diseases are a group of chronic inflammatory diseases characterized by joint and systemic multi-organ involvement, including rheumatoid arthritis, systemic lupus erythematosus, and Sjogren’s syndrome, among others. The pathogenesis of these diseases is related to the abnormal activation and regulatory imbalance of the immune system. The prevalence and morbidity of rheumatic immune diseases are high, imposing a significant burden on patients' quality of life and socio-economic costs. Currently, the treatment of rheumatic immune diseases mainly relies on Western medicine, such as non-steroidal anti-inflammatory drugs, glucocorticoids, disease-modifying antirheumatic drugs, and biologics. However, the therapeutic effects of Western medicine are not ideal, some patients poorly respond or are resistant to Western medicine, and long-term use often causes various adverse reactions.
AIM
To systematically evaluate the efficacy and safety of Tripterygium wilfordii glycosides tablets combined with Western medicine in the treatment of patients with rheumatic immune diseases.
METHODS
This study conducted a meta-analysis to systematically evaluate the efficacy and safety of Tripterygium wilfordii glycosides tablets combined with Western medicine for patients with rheumatic immune diseases. Chinese and English databases were searched for randomized controlled trials (RCTs) on the treatment of rheumatic immune diseases with Tripterygium wilfordii glycosides tablets combined with Western medicine. The quality of the included studies was assessed using the Cochrane risk of bias assessment tool. Meta-analysis was performed using RevMan 5.4 software.
RESULTS
The meta-analysis included 11 RCTs involving 1026 patients with rheumatic immune diseases. The combined treatment significantly reduced the risk of disease recurrence (relative risk = 1.07, 95% confidence interval: 1.01-1.15, P < 0.05) and showed no significant heterogeneity (I 2 = 0%, P = 0.53), indicating that Tripterygium wilfordii glycosides tablets combined with Western medicine is an effective method to reduce the possibility of postoperative recurrence in patients with rheumatic immune diseases. However, due to the limited number and quality of the studies included, these results should be interpreted with caution.
CONCLUSION
Tripterygium wilfordii glycosides tablets combined with Western medicine is an effective and safe treatment option for patients with rheumatic immune diseases and can be considered a clinical choice. However, more high-quality research is needed to validate this conclusion and provide more solid evidence for clinical practice.
Multidimensional characteristics are associated with pain severity in osteonecrosis of the femoral head
Authors: Yue Chen , Xue Zhang , Cheng Yan , Sun Chaojun , Liu Youwen , Xu Bin , Guo Jiayi 
Published: November 2024

AimsPain is the most frequent complaint associated with osteonecrosis of the femoral head (ONFH), but the factors contributing to such pain are poorly understood. This study explored diverse demographic, clinical, radiological, psychological, and neurophysiological factors for their potential contribution to pain in patients with ONFH.MethodsThis cross-sectional study was carried out according to the “STrengthening the Reporting of OBservational studies in Epidemiology” statement. Data on 19 variables were collected at a single timepoint from 250 patients with ONFH who were treated at our medical centre between July and December 2023 using validated instruments or, in the case of hip pain, a numerical rating scale. Factors associated with pain severity were identified using hierarchical multifactor linear regression.ResultsRegression identified the following characteristics as independently associated with higher pain score, after adjustment for potential confounders: Association Research Circulation Osseous classification stage IIIa or IIIb, bone marrow oedema, grade 3 joint effusion, as well as higher scores on pain catastrophizing, anxiety, and central sensitization. The final model explained 69.7% of observed variance in pain scores, of which clinical and radiological factors explained 37%, while psychological and neurophysiological factors explained 24% and demographic factors explained 8.7%.ConclusionMultidimensional characteristics jointly contribute to the severity of pain associated with ONFH. These findings highlight the need to comprehensively identify potential contributors to pain, and to personalize management and treatment accordingly.Cite this article: Bone Joint Res 2024;13(11):673–681.
Teachers Reported Knowledge, Skills, and Usefulness of Professional Development on the Self-Determined Learning Model of Instruction
Authors: Matusevich Hunter A. , Shogren Karrie A. , Raley Sheida K. , Lane Kathleen Lynne , Frey Bruce B. 
Published: November 2024

Abstract
Understanding the impacts of professional development (PD) on teachers’ perceptions of their knowledge, skills, and usefulness (KSU) of evidence-based practices is important, particularly for self-determination interventions in inclusive, secondary classrooms. Limited research exists examining the impacts of self-determination intervention PD on teachers’ learning outcomes. In this study, we analyzed the impacts of PD on the Self-Determined Learning Model of Instruction (SDLMI) delivered during a 3-year research project on trained teachers’ self-reported KSU of self-determination. Results suggested there were positive impacts on teachers’ KSU of self-determination after PD. Implications for future research and practice are discussed.
Comparing college students’ mood states among immersive virtual reality, non-immersive virtual reality, and traditional biking exercise
Authors: Liu Wenxi , McDonough Daniel J. , Gao Zan 
Published: November 2024

Objectives
This study examined differences in young adults’ mood states during immersive virtual reality (VR), non-immersive VR, and traditional exercise biking sessions.

Design
Repeated-measure study design.

Methods
Forty-nine college students (34 females; Mage = 23.6 years) completed three separate 20-minute exercise biking sessions: (1) immersive VR biking using the PlayStation 4 + VirZoom VR bike; (2) non-immersive VR biking using the Gamercize bike + Xbox 360; and (3) traditional stationary biking using the Spirit Fitness XBU55. Participants’ mood states (anger, confusion, depression, fatigue, tension, and vigor) were assessed by using the Brunel Mood Scale after each session.

Results
Statistically significant differences were observed between biking sessions for all components of mood [F (2, 96) = 3.84–278.56, p < 0.05, η2 = 0.07–0.85], except for tension (p > 0.05). Results indicated non-immersive VR biking yielded significantly higher anger compared to immersive VR biking; non-immersive VR biking yielded significantly higher confusion compared to immersive VR biking and traditional biking, respectively; immersive VR biking yielded significantly lower depression compared to traditional biking; both immersive VR biking and non-immersive VR biking yielded significantly lower fatigue compared to traditional biking; and immersive VR biking yielded significantly higher vigor compared to non-immersive VR biking) and traditional biking, respectively.

Conclusion
Findings suggested the immersive VR-based biking exercise may facilitate in reducing the negative feelings, such as anger, fatigue, depression, and improving positive feeling, such as vigor, among college students. The immersive VR-based exercise appeared to be a feasible approach for motivating college students participating in physical activity and improving overall mood states.
Association between dietary niacin intake and chronic obstructive pulmonary disease among American middle-aged and older individuals: A cross-section study
Authors: Shi Yushan , Pu Shuangshuang , Zhang Chunlai , Xu Kanghong , Guo Xuxiao , Gao Wei 
Published: November 2024

Background
The attention towards the relationship between chronic obstructive pulmonary disease (COPD) and dietary intake is escalating. However, the effects of dietary niacin on COPD in middle and older individuals remains unclear. This study aimed to illuminate the connection between dietary niacin intake and COPD.

Methods
This cross-sectional study analyzed 7,170 participants from the National Health and Nutrition Examination Survey (NHANES) spanning the years 2013 to 2018. Participants were categorized into four groups based on quartiles of dietary niacin intake. To examine the association between covariates, dietary niacin intake, and COPD, we employed univariate analysis and multivariate logistic regression equations. Additionally, restricted cubic splines were utilized to assess linearity. Furthermore, we conducted stratified and interaction analyses to evaluate the stability of the relationship in diverse subgroups.

Results
Among the 7,170 participants, 11.6% (834/7170) were diagnosed with COPD. The multivariable adjusted odds ratios (ORs) and 95% confidence intervals (CIs) for COPD were 0.96 (95% CI: 0.77–1.19, p = 0.706), 0.78 (95% CI: 0.62–0.99, p = 0.038), and 0.76 (95% CI: 0.57–1.00, p = 0.047), respectively, when comparing the second, third, and fourth quartiles of niacin intake levels to the lowest quartile (p for trend = 0.017). An inverse association was observed between the occurrence of COPD and dietary niacin intake (nonlinear: p = 0.347). Stratified analyses revealed no significant differences or interactions.

Conclusion
Our findings suggest a potential link between increased dietary niacin intake and a decreased prevalence of COPD.
Assessment of scabies and its associated factors in Hawassa Zuria District, Southern Ethiopia: A cross-sectional study
Authors: Dejen Philmon , Girma Mekonnen , Chernet Adane , Vaz Nery Susana , Shimelis Techalew 
Published: November 2024

Background
Scabies is a common but neglected skin disease caused by the parasitic mite Sarcoptes scabiei var. hominis. Globally, the disease affects more than 400 million people. Although Ethiopia is a high-burden country for scabies, its epidemiology has not been well assessed. Therefore, this study aimed to determine the prevalence of scabies, clinical features, and associated risk factors in the communities of the Hawassa Zuria District of the Sidama Region, southern Ethiopia.

Methods
A community-based cross-sectional study was conducted from September through November 2023 in the Hawassa Zuria District. A multistage random sampling technique was applied to enrol 511 participants. The International Alliance for Control of Scabies Diagnostic Criteria was used for examination. The data were collected electronically using the Open Data Kit application through a pretested interviewer-administered questionnaire. Analysis was performed using STATA software. The binary logistic regression analyses model was used to assess the association between each independent variable and scabies prevalence. During the bivariate logistic regression analyses a variable with a p-value of < 0.25 was a candidate for multivariable logistic regression analyses. In multivariable logistic regression analyses the odds ratios with a 95% confidence interval and a p-value less than 0.05 were used to describe the strength of the association and statistical significance.

Results
The median age of the study participants was 19 years (interquartile range: 11–32 years), and 52.6% of the participants were females. The overall prevalence of scabies was 6.3% (95% CI 4.3–8.7%). The majority of individuals with scabies had a moderate degree of severity. The most frequent lesions were intensely itchy papules, vesicles, and pustules that appeared in the interdigital space, flexor wrist surfaces, and elbow. Males were more likely to have scabies [adjusted odds ratio (AOR) = 2.57; 95% CI: 1.10–6.00] than females were and it was not influenced by age. The risk of scabies was higher for households with low (AOR = 3.88; 95% CI: 1.01–14.91) and middle-class wealth index (AOR = 4.43; 95% CI: 1.13–17.33), as well as for individuals residing in households with an overcrowding index >1.5 (AOR = 2.64; 95% CI: 1.13–6.18), in those individuals who washed their hands with water only (AOR = 2.98; 95% CI: 1.23–7.24), in those who used an unimproved water source (AOR = 2.98; 95% CI: 1.25–7.06) and in those who slept on the floor (AOR = 2.70; 95% CI: 1.17–6.18).

Conclusion
The observed moderate presence of scabies in the study area stresses the need to strengthen disease management efforts, improve wealth, reduce overcrowding, ensure clean water access, and promote better hygiene practices to reduce the spread of scabies.
Expression markers of human skeletal muscle associated with disorders of glucose metabolism in the basal and postprandial state
Authors: Makhnovskii P. A. , Kurochkina N. S. , Vepkhvadze T. F. , Tomilova A. O. , Lednev E. M. , Shestakova M. V. , Popov D. V. 
Published: November 2024

BACKGROUND. Skeletal muscles play a key role in the organism’s carbohydrate metabolism. Dysregulation of insulin-dependent glucose uptake in skeletal muscle disrupts carbohydrate metabolism in the organism and can lead to the development of obesity and type 2 diabetes.AIM. To identify expression markers (genes) of human skeletal muscle associated with disorders of glucose metabolism in the basal state and after a mixed meal normalized for body mass.MATERIALS AND METHODS. The study involved three groups of 8 people: healthy volunteers, obese patients without and with type 2 diabetes. Venous blood samples were taken in the morning (09:00) after an overnight fast and 30 min, 60 min, 90 min, 120 min, and 180 min after ingestion of a mixed meal normalized by body mass (6 kcal/kg). Biopsy samples from m. vastus lateralis was taken before and 1 h after a meal to assess gene expression (RNA sequencing) and search for genes correlating with markers of impaired glucose metabolism in the basal and postprandial state.RESULTS. Strong correlations (|ρ|>0.7 and p<0.001) between the gene expression and the level of insulin, C-peptide, glucose or glycated hemoglobin in the basal and/or postprandial state was found for 75 genes. Of these, 17 genes had marked differences (>1.5-fold) in expression between healthy people and patients, or differences in expression changes in response to a meal. We can note genes whose role in impaired glucose metabolism has already been shown earlier (FSTL1, SMOC1, GPCPD1), as well as a number of other genes that are promising for further study of the mechanisms of insulin resistance in skeletal muscle.CONCLUSION. Skeletal muscle expression markers were identified as promising candidates for future targeted studies aimed at studying the mechanisms of insulin resistance and searching for potential therapeutic targets.
Real-world effectiveness and safety of fixed-ratio combination insulin glargine 100 u/ml plus lixisenatide in adults with type 2 diabetes (T2DM): subanalysis of the international, multicentre, prospective observational study SUCCESS in the Russian population
Authors: Vikulova O. K. , Atanesyan R. A. , Movsesyan S. D. , Kasatkina Yu. P. , Perevyazka A. A. , Zaytseva E. L. , Kharakhulakh M. I. , Andreeva N. V. , Krivosheyeva I. A. , Vorobyev S. V. , Saprina T. V. , Avaliani D. A. , Prudnikova M. A. , Shestakova M. V. , Mokrysheva N. G. 
Published: November 2024

AIM: To evaluate the impact a fixed-ratio combination of insulin glargine(100U/ml) and lixisenatide(iGlarLixi) on the glycemic control in Russian study T2D population uncontrolled on OAD ± insulin therapy in real-world settings.MATERIALS AND METHODS: The Russian subanalysis of international, multicentre, prospective, observational SUCCESS study included 160 T2DM patients who had initiated iGlarLixi within 1 month prior to study inclusion from 11 regions of the Russian Federation. The primary endpoint — HbA1c change from baseline to month 6. Secondary endpoints: HbA1c change after 12 months, achievement of target HbA1c levels after 6 and 12 months; change in FPG and PPG, change in body weight after 6 and 12 months, iGlarLixi dose dynamics. Safety endpoints: adverse events, serious adverse events, adverse events of special interest, frequency of hypoglycemia during the study period.RESULTS: The average age of patients in the Russian population was 60.8±9.4 years; average duration of T2DM was 11.4 years, mean HbA1c — 9.3±1.5%; mean BMI 33.3 kg/m2. Prior to the study, most patients were on 2 (36.3%) and 3 OADs (27.5%), 32.5% — on insulin therapy. The mean change of HbA1c at month 6 was -1.81%, and -2.03% at month 12. 51.3% patients achieved individual HbA1c targets at month 12, 46.7% of patients achieved the HbA1c target without hypoglycemia and weight gain. The decrease of body weight in 12 months was -3.3±4.4 kg. During the study period, 17 cases of hypoglycemia were recorded (0.11 events per patient-year); 1 severe hypoglycemia (0.01 events per patient-year). The total number of adverse events (AEs) was 43(26.9%), serious AEs - 10 (6.3%).CONCLUSION: According to the results of this prospective real world sub-group analysis, initiation of iGlarLixi in Russian adults with T2DM uncontrolled on OADs ± insulin significantly improves glycemic control with low risk of hypoglycemia and no body weight increase.
AS DIRETRIZES PARA A FORMAÇÃO DOCENTE E O PROGRAMA INSTITUCIONAL DE BOLSA DE INICIAÇÃO À DOCÊNCIA (PIBID): A FORMAÇÃO INICIAL DOS PROFESSORES DE GEOGRAFIA E O ENSINO NA CONTEMPORANEIDADE
Authors: Carvalho Josias Ivanildo Flores de , Santos Francisco Kennedy Silva dos , Sousa Laryssa de Aragão 
Published: November 2024

Este artigo tem como objetivo apresentar de maneira crítico-situacional as diretrizes para a formação inicial de professores de Geografia, a partir da resolução de nº 2 de 1º de julho de 2015 que define as Diretrizes Curriculares Nacionais - DCNs para a formação inicial em nível superior de professores e destacar a importância do Programa Institucional de Bolsa de Iniciação à Docência (PIBID) no processo de formação inicial dos licenciandos em Geografia. Para a realização deste estudo utilizou-se a pesquisa qualitativa dado que privilegia a temática escolhida, fazendo uso especificamente de análise documental e revisão de literatura. A fundamentação teórica está ancorada no campo da Geografia e da Educação, construindo assim uma reflexão crítica a respeito da formação inicial dos licenciandos em Geografia, na pretensão de uma educação geográfica mais significativa na contemporaneidade. Diante disto, pode-se afirmar que quando as diretrizes curriculares para a formação inicial dos professores estão bem desenhadas e atreladas também a programas de incentivo à docência, com destaque para o PIBID, pode-se avançar em questões fundamentais para as licenciaturas, como uma formação inicial exitosa e professores com habilidades fundamentais para um ensino-aprendizagem de Geografia mais voltada a questões atuais dos alunos e da sociedade globalizada.
A model for measuring the quality of public policies in innovation
Authors: Pakes Paulo Renato , Torkomian Ana Lúcia Vitale , Silva Brena Bezerra , Borrás Miguel Ángel Aires , Bianchini Vívian Karina , Razzino Carlos do Amaral 
Published: November 2024

Goal : This article presents a model for measuring the quality of public policies on innovation and its validation in a public policy on technology parks (SPTec)
Design/methodology/approach: A survey on the quality of public policy SPTec was carried out. Through descriptive analysis, it was possible to verify the quality of public policy in five determinants of quality. Factor analysis allowed the regrouping of quality attributes into new determinants for SPTec public policy. Finally, the multiple regression analysis allowed us to analyze the dependence relationship between the variables.
Results: The public policy SPTec is immature in terms of process quality, quality of the relation, and quality of the result. In addition, we identified the determinants that should be prioritized in the implementation of SPTec public policy in a possible reformulation. Finally, the attributes of quality that generate the greatest effect in terms of an increase in user satisfaction are shown, as well as those that generate a decrease in satisfaction if they have an increase in their performance.
Limitations of the investigation: Because of the chosen research approach, the research results may lack generalizability. Therefore, researchers are encouraged to test the proposed propositions further.
Practical implications: As a limitation, there is the fact that the factor analysis of public policy SPTec can only be generalized at the level of the same. Likewise, the presented model for measuring quality in the public sector requires adaptation for each public policy analyzed.
Originality/value: This article fills a gap regarding the lack of instruments for measuring the quality of public policies in innovation systems.
The relationship between mixed venous blood oxygen saturation and pulmonary arterial and venous pressures in patients with heart failure
Authors: Funaki Ryuji , Ogawa Kazuo , Mashitani Yuto , Oh Takuya , Kashiwagi Yusuke , Tanaka Toshikazu D. , Nagoshi Tomohisa , Kawai Makoto , Yoshimura Michihiro 
Published: November 2024

AbstractRecent discoveries have identified intrapulmonary bronchopulmonary anastomoses (IBAs) as a relatively common phenomenon forming intrapulmonary right‐to‐left shunts. This study hypothesizes that IBAs play a significant role in the pathophysiology of heart failure. We aim to investigate the impact of these intrapulmonary right‐to‐left shunts on pulmonary arterial and venous pressures in heart failure patients, utilizing mixed venous oxygen saturation (SvO₂) as a key measurement. This study included 237 patients with heart failure who underwent cardiac catheterization. The relationships between SvO₂ and pulmonary artery systolic pressure (sPAP), pulmonary artery wedge pressure (PAWP), and left ventricular end‐diastolic pressure (LVEDP) were examined using various statistical methods (single regression analysis, partial correlation analysis, structural equation modeling, and Bayesian estimation). All statistical methods that we performed showed that SvO₂ was significantly and negatively correlated with both sPAP and PAWP (p < 0.01, respectively). However, SvO₂ did not significantly correlate with LVEDP. These results suggest that a decrease in SvO₂ leads to an increase in PAWP and sPAP, while LVEDP is only passively influenced by PAWP. This phenomenon likely reflects the impact of an intrapulmonary right‐to‐left shunt caused by IBAs. The decrease in SvO₂ causes an increase in sPAP and may also cause an increase in PAWP via IBAs.
What Can Historicising Rawls Achieve?
Authors: Andersson Emil , Olsson Yaouzis Nicolas 
Published: November 2024

Abstract
This essay explores the implications of historicising John Rawls’s theory of justice. While historical research on Rawls and his social context has provided valuable insights, some scholars argue that historicising carries significant philosophical consequences. This paper critically examines one such argument that contends that historicising Rawls’s theory demonstrates its contextual nature, undermines its diagnostic powers, and leads to its complete dissolution. We offer a reconstruction of this argument and show that it fails. Further, while we argue that this argument fails, we go on to suggest that historical evidence may contribute to a defensive argument against appeals to expert opinion. By examining the appropriate relationship between historical research and philosophy, this essay contributes to the evaluation of the historicist critique and offers insights into the broader role of historical research in philosophical discourse.