bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cutaneous manifestations of diabetes mellius: a clinico epidemiological study
Authors: Venkatesh S. , Thamizhselvi S. , . Tharini 
Published: January 2019

<p class="abstract"><strong>Background:</strong> Diabetes mellitus is one of the commonest non communicable diseases seen all over the world, constituting 49% from India, i.e., 72 million patients according to the Indian Council of Medical Research. The aim of the study was to study the various skin manifestations in diabetic patients and to correlate them with glycemic levels.</p><p class="abstract"><strong>Methods:</strong> Patients for the study were chosen among those who were on treatment for diabetes mellitus and presented to the skin department with various cutaneous manifestations.<strong></strong></p><p class="abstract"><strong>Results:</strong> Infections were commonest cutaneous manifestations in both type 1 and type 2. Among infections, fungal infections were commoner followed by bacterial infections. Among house wives, the commoner was candidal dermatosis intertrigo-toe/finger cleft followed by chronic paronychia. Among bacterial infections, erythrasma was commonly followed by pyoderma. Among pyodermas, furunculosis was common. Most common associated dermatoses were acanthosis nigricans and acrochordons. Treatment-related manifestations were not found.</p><p><strong>Conclusions:</strong> In type 2 diabetic patients, infections were commonly followed by acanthosis nigricans, acrochordons, and generalized pruritus. Glycemic levels were higher in those with candidiasis and also with pyodermas. </p>
Czym jest i czym nie jest starzenie komórki?
Authors: Sikora Ewa , Bielak-Ĺťmijewska Anna , Mosieniak Grażyna 
Published: January 2019

Cell senescence is a process that occurs due to telomere erosion or can be induced by various stresses. Senescent cells cease to divide but remain alive, metabolically active and able to secrete many molecules. They also show many hallmarks of senescence, such as enlarged size, increased granularity, increased activity of SA-Î˛-galactosidase, increased level of cyclin-dependent kinase inhibitors, p16 and p21, and DNA damage foci. Originally, cell senescence was attributed to proliferating normal cells, in contrast to cancer cells, which were considered as those endowed with indefinite growth ability. Recently, it has become evident that anticancertreatment induces senescence in cancer cells. Moreover, certain hallmarks of senescence were detected in non-proliferating post-mitotic cells. There are many signalling pathways involved in cell senescence, but the most prevalent is the DNA damage response pathway. In this review we have summarized our long lasting input in the global study of the mechanisms of senescence of normal and cancer cells and discussed the diversity of the concept of cell senescence.
Rola autofagii w komórkach nowotworowych: charakterystyka wzajemnych zależności pomiędzy procesami autofagii i apoptozy; modulacja autofagii jako nowa strategia terapeutyczna w leczeniu glejaków
Authors: Ciechomska Iwona Anna 
Published: January 2019

The Noble Assembly decided to award the 2016 Nobel Prize in Physiology or Medicine to Yoshinori Ohsumi for his discoveries of mechanisms of autophagy, a fundamental process for degrading and recycling cellular components. His discoveries opened a path to understanding the fundamental importance of autophagy in many physiological processes, such as adaptation to starvation or response to infection. Mutations in autophagy genes can cause disease, and the autophagic process is involved in several conditions including cancer and neurological disease. It shows the importance of autophagy research, as many questions remain open. The main aim of our research presented here was to better understand the role of autophagy in cancer. Here, we present articles concerning correct monitoring autophagy in cancer cells, characterization of the molecular links between autophagy and apoptosis and analysis of autophagy as a new therapeutic strategy in glioma.
Tanggung Jawab Pelaku Usaha Pertambangan Rakyat dalam Reklamasi Gumuk Setelah Kegiatan Tambang
Authors: Prayogo Ade Lutfi 
Published: January 2019

The responsibility of mining businesses in carrying out post-mining reclamation activities applies to all mining business permits including holders of the People's Mining Permit (IPR). The arrangement of post-mining land reclamation activities for small-scale mining business people on what so-called ‘gumuk’ mining is still not efficient regarding its making and implementation. Legal responsibility for IPR holders in the preparation of plans, implementation, and sanctions provided still depends on regulations made by the regional government. The norm gap still exists if there is a lack of guarantee costs for post-mining reclamation due to the absence of mandatory guarantee funds. This is evidenced by the fact that there are still many regional governments that have not made regulations on reclamation and post-mining by IPR holders. Therefore, it is necessary to add norms to regulations that regulate reclamation and post-mining activities for community mining businesses. The addition of norms also needs to be done to the implementation rules so that environmental functions can be functioned properly by community mining business actors.
Keywords: Responsibility, Business Actors, People's Mining
New Insights on Mechanisms Controlling Fracturing-Fluid Distribution and Their Effects on Well Performance in Shale-Gas Reservoirs
Authors: Liu Yongzan , Leung Juliana Y. , Chalaturnyk Richard J. , Virues Claudio J. 
Published: January 2019

Summary
Many stimulated shale-gas wells experience surprisingly low fracturing-fluid recoveries. Fracture closure, gravity segregation, proppant distribution, and shut-in (soaking) time have been widely postulated to be the contributing factors. This study examines the effects of these factors on fracturing-fluid distribution and subsequent well performance using flow and geomechanical simulations. In the end, two real-field examples are used to validate the findings in this study.
Geomechanical simulation is used to capture the complex post-closure fracture geometry caused by nonuniform proppant distribution. The geometry is then passed into a series of 3D numerical flow models that are constructed using petrophysical parameters, fluid properties, and operational constraints representative of the Horn River shale-gas reservoir. Within the flow simulation, the hydraulic fracture is represented explicitly in the computational domain by means of local-grid refinement, and the physical process of fracture closure during shut-in and production periods is modeled by adjusting the fracture volume and fracture conductivity dynamically. Non-Darcy behavior caused by high gas velocity in the fracture and matrix desorption are considered. The results of the geomechanical simulation confirm the formation of a residual opening above the proppant pack in a partially propped fracture. The residual opening offers a highly conductive flow path for the gas, which is much more mobile than the water-based fracturing fluid, and this difference in mobility further aggravates gravity segregation. Gravity segregation might lead to water accumulating near the bottom of a vertical planar fracture, but reduced fracture conductivity could limit the segregation and promote a more uniform fluid distribution. Water uptake into the matrix is influenced by forced and spontaneous imbibition caused by the large pressure differential across the matrix/fracture interface and matrix capillarity. Additional water is displaced into the matrix as pressure depletes and the fracture closes. Fracturing-fluid-penetration depth increases with shut-in time, resulting in an enhancement in the initial gas rate, but lower late-time production is also observed.
Analysis of the residual opening of a partially propped fracture and its role in fracturing-fluid distribution in three dimensions is novel. Field examples suggest that considering the various physical mechanisms investigated in this study could improve the accuracy of the numerical model for history matching and the reliability of the ensuing production forecasting. The findings in this study might provide a better understanding of fracturing-fluid distribution, which is useful for optimizing production strategies and operations concerning hydraulically fractured shale-gas reservoirs.
A model of molecular characteristics to classify patients with WHO Grade III gliomas
Authors: Zhang Botao , Lu Dan , Shen Rongfang , Cheng Shujun , Feng Lin 
Published: January 2019

Abstract
Background: The World Health Organization (WHO) Grade III gliomas display large within-group differences, and no studies have attempted to classify Grade III gliomas to our knowledge. We aimed to classify Grade III gliomas and complement the existing molecular classification system.
Methods: We used microarrays to profile glioma progression from normal brains (n = 5) to WHO Grade II (n = 97) to Grade III (n = 34) to Grade IV samples (n = 89). Using bioinformatics analysis to construct a model to evaluate the diagnosis and prognosis of patients with Grade III gliomas.
Results: We identified 27 gene expression patterns of glioma progression and found Grade III glioma samples had large within-group differences. There were 506 differentially expressed genes in Grade III glioma samples and used to construct a network. Three clusters were identified, we chose the first two genes with the most significant P values in each cluster, age and Isocitrate Dehydrogenase 1 (IDH1) mutations to construct a model to score and high risk scores were significantly associated with poor survival in our data and two independent datasets for patients with Grade III gliomas (P = 1.12e−03, P = 2.55e−04, P = 5.93e−06, respectively). The ROC area under the curve was 80.0%, 80.9% and 76.6%, respectively.
Conclusions: Our results revealed that the model was able to predict the diagnosis and prognosis of patients with Grade III gliomas, assisting with post-surgical treatment management and providing a priori molecular targeting treatment.
Keywords: Grade III gliomas, model, molecular characteristics, predictive.
Development of a bioreactor system for the remediation of endosulphan
Authors: Jesitha K. , Harikumar P. S. 
Published: January 2019

Abstract
A bioreactor system that consisted of Pseudomonas fluorescens cells immobilised in calcium-alginate beads was utilised to remediate endosulphan contaminated water and soil. A packed bed reactor system was designed for the bio-degradation of endosulphan in artificially spiked water samples (initial concentration of endosulphan: 350 µg/L). Reactor studies with cell-immobilised Ca-alginate beads were conducted after checking their efficiency through batch and column degradation studies. The results showed that the concentration of toxic isomers of endosulphan (endosulphan alpha and endosulphan beta) was below the limit in the bioreactor during the 7th day of the experiment. Experiments conducted with contaminated soil samples (initial concentration of endosulphan: 1,000 μg/kg) indicated that the toxic isomers of endosulphan degraded to below the detection limit within 10 days and monitoring of endosulphan residues on the 14th day revealed that almost complete degradation of metabolites of endosulphan had occurred. The bioreactor system designed can be scaled up for remediation of endosulphan in contaminated areas.
Contribución al conocimiento del género Linum (Linaceae) en Veracruz, México
Authors: Burgos-Hernández Mireya , Castillo-Campos Gonzalo 
Published: January 2019

Antecedentes y Objetivos: Linum es el género más grande de la familia Linaceae y cuenta con una amplia importancia socioeconómica. En Veracruz, la taxonomía del grupo es desconocida, a pesar de ser el tercer estado de mayor diversidad florística de México. El presente trabajo tuvo como objetivo conocer la riqueza específica del género Linum y brindar herramientas para su correcta identificación en el estado de Veracruz.Métodos: Se revisaron los especímenes de Linum colectados en Veracruz y depositados en los herbarios CHAPA, ENCB, MEXU y XAL, así como los ejemplares escaneados disponibles en las páginas de TROPICOS y JSTOR Global Plants. Paralelamente, a partir de estudios florísticos regionales, se generó una lista preliminar de especies. La determinación y descripción de ejemplares se realizó utilizando claves de diferentes tratamientos taxonómicos y floras, así como el análisis de la información contenida en la literatura y en bases de datos digitales.Resultados clave: Se identificaron ocho especies de Linum distribuidas en Veracruz, de las cuales tres constituyen nuevos registros verificados para el estado y cuatro son consideradas endémicas del país. Se proporciona una clave dicotómica para su identificación, fotografías, descripciones morfológicas, sinonimia y datos ecológicos. Se incluyen mapas de distribución y se amplía el rango de distribución para algunos taxa.Conclusiones: Cincuenta por ciento de las especies identificadas para Veracruz son endémicas para México, de las cuales Linum orizabae es la de mayor presencia en el estado. Se incluyen tres especies raras o poco frecuentes que no habían sido registradas formalmente para Veracruz, todas ellas vulnerables a la degradación y pérdida de hábitat. Lo anterior, junto con múltiples errores de identificación detectados, refleja el escaso conocimiento del grupo y la necesidad de inventariar, analizar y caracterizar de manera integral la diversidad de lináceas en la región, y en general, del país.
User Involvement in Developing the MYPLAN Mobile Phone Safety Plan App for People in Suicidal Crisis: Case Study
Authors: Buus Niels , Juel Anette , Haskelberg Hila , Frandsen Hanne , Larsen Jette Louise Skovgaard , River Jo , Andreasson Kate , Nordentoft Merete , Davenport Tracey , Erlangsen Annette 
Published: January 2019

Background
The effect of safety planning for people in suicidal crisis is not yet determined, but using safety plans to mitigate acute psychological crisis is regarded as best practice. Between 2016 and 2017, Australian and Danish stakeholders were involved in revising and updating the Danish MYPLAN mobile phone safety plan and translating the app into a culturally appropriate version for Australia.

Objective
The objective of this study was to examine the negotiation of stakeholders’ suggestions and contributions to the design, function, and content of the MYPLAN app and to characterize significant developments in the emerging user-involving processes.

Methods
We utilized a case study design where 4 focus groups and 5 user-involving workshops in Denmark and Australia were subjected to thematic analysis.

Results
The analyses identified 3 consecutive phases in the extensive development of the app: from phase 1, Suggesting core functions, through phase 2, Refining functions, to phase 3, Negotiating the finish. The user-involving processes continued to prevent closure and challenged researchers and software developers to repeatedly reconsider the app’s basic user interface and functionality. It was a limitation that the analysis did not include potentially determinative backstage dimensions of the decision-making process.

Conclusions
The extended user involvement prolonged the development process, but it also allowed for an extensive exploration of different user perspectives and needs.
Competencias básicas y transversales, nuevas demandas de formación en la educación superior
Authors: Piña Jiménez Irma 
Published: January 2019

El presente artículo parte del cuestionamiento que se hace a los fines de la educación superior en el nuevo siglo, en concordancia con la presencia de la noción de competencia y las implicaciones que esta tiene en la práctica educativa que se ocupa de la formación de los profesionales. Para ella retoma de manera especial, algunas aportaciones que el autor Bernard Rey de la Universidad Libre de Bruselas elabora, sobre las competencias transversales.
Posteriormente analiza algunos argumentos en torno a las preguntas ¿Cómo se propicia la formación del profesional competente? y ¿Cómo se adquieren las competencias? centrándose en el caso de la enfermería universitaria.
En el último apartado, se hace una reflexión respecto a la naturaleza de los contenidos no escritos que derivan del saber práctico profesional, cuya enseñanza posee la ventaja de no desvincularse de su práctica.
Austeridad e inversión privada en carreteras de México
Authors: Mendoza Méndez José Enrique 
Published: January 2019

<p class="Standard">La austeridad aplicada al presupuesto se expresa en recortes masivos del gasto público y el consecuente deterioro de bienes y servicios públicos. Las aún vigentes políticas del Consenso de Washington (CW), determinan que quede poco espacio para la inversión pública, en particular para los programas de inversión carretera en general, y para Caminos y Puentes Federales de Ingresos y Caminos Conexos (CAPUFE) en particular. Ante la falta de recursos para la construcción y modernización de este sector, se abre la puerta para la participación de las Asociaciones Público Privadas (APP) en la red troncal, por medio de concesiones, paquetes de aprovechamiento de activos y Proyectos de Prestación de Servicios (PPS). Este esquema termina supeditando el presupuesto público a las necesidades de rentabilidad del capital monopólico financiero. </p>
Deuda pública de Argentina: de la última dictadura al default de 2001
Authors: Val María Emilia 
Published: January 2019

<p align="right"> </p><p>La problemática de la deuda pública constituye uno de los temas centrales para comprender la historia argentina de las últimas décadas. Los recientes episodios relacionados con la deuda (la crisis y cesación de pagos de 2001, los canjes de 2005 y 2010, el conflicto con los llamados fondos buitre, entre otros) no se pueden entender sin atender al proceso de endeudamiento y la dinámica de relaciones asociadas, del que son consecuencia. Específicamente, el crecimiento exponencial del endeudamiento soberano externo desde mediados de los años setenta hasta la crisis de pago de 2001 tuvo importantes derivaciones en el plano económico, financiero, político y social: la acumulación de niveles de deuda insostenibles, la injerencia creciente de los acreedores sobre los lineamientos de la política económica local y la transferencia de una enorme masa de recursos para su pago explican en gran medida el deterioro de las cuentas fiscales, de las condiciones de vida de amplias franjas de la población, los desequilibrios económicos y las persistentes trabas al desarrollo. En este sentido, el objetivo de este artículo es reconstruir el derrotero histórico de la deuda soberana argentina, describiendo su evolución y principales transformaciones en las diferentes etapas comprendidas entre 1976 y 2001.</p><p> </p><div><br clear="all" /><br /><div><p> </p></div></div>
Pensamiento Constructivo y Afrontamiento al Estrés en Estudiantes Universitarios
Authors: Contreras Gutiérrez Ofelia , Chávez Becerra Margarita , Aragón Borja Laura Edna 
Published: January 2019

La presente investigación tuvo como objetivo establecer la relación posible entre pensamiento constructivo y estilos de afrontamiento al estrés en estudiantes universitarios. Se trabajó con una muestra aleatoria de 184 estudiantes de tres campus multidisciplinarios de la UNAM, 107 mujeres y 77 hombres. Se aplicaron el Cuestionario de Pensamiento Constructivo para Estudiantes Universitarios (CPCE) y la Escala de Afrontamiento para Adolescentes (ACS). El 77% de los estudiantes obtienen puntuaciones entre adecuado y alto pensamiento constructivo, mientras que el 23% califica bajo pensamiento constructivo. La mayoría de los estudiantes refiere utilizar estrategias del estilo dirigido a la resolución de problemas con frecuencia de a menudo (70 a 89), mientras que las estrategias improductivas son raramente utilizadas (30 a 49). En el análisis de las relaciones entre estilos de afrontamiento y pensamiento constructivo se denota que a puntuaciones altas en pensamiento constructivo corresponden puntuaciones altas en el empleo de estrategias de afrontamiento dirigidas a la solución de los problemas, también se observa una correlación directa entre pensamiento no constructivo y afrontamiento improductivo. El afrontamiento conductual es la subescala que muestra una correlación considerable con el estilo de afrontamiento orientado a la solución de problemas, mientras que la falta de Afrontamiento Emocional, la baja autoestima, y la incapacidad para sobreponerse se asocian con la elección de un estilo de afrontamiento improductivo. El estilo de afrontamiento en relación con los demás se asocia con afrontamiento conductual, baja autoestima e incapacidad de sobreponerse. Los estudiantes que poseen baja autoestima, e incapacidad para manejar sus emociones, pero poseen la habilidad para afrontar conductualmente, optan por buscar redes de soporte social como alternativa de afrontamiento.
Industry Tax Planning and Stock Returns
Authors: Heitzman Shane M. , Ogneva Maria 
Published: January 2019

ABSTRACT
We find evidence that equity returns increase with the propensity for tax planning in a firm's industry. This risk premium is imposed on all firms in the industry, even those that are less aggressive than their peers. The industry-based risk premium coexists with a firm-specific discount associated with active tax planning strategies that carry low systematic risk. The discount on tax planning at the firm level, however, is dwarfed by the premium on tax planning at the industry level, and is concentrated in industries that are less likely to attract scrutiny from the tax authority.
How Disaggregated Forecasts Influence Investor Response to Subsequent Earnings Announcements
Authors: Clor-Proell Shana M. , Hirst D. Eric , Koonce Lisa , Seybert Nicholas 
Published: January 2019

ABSTRACT
Firms often issue disaggregated earnings forecasts, and prior research reveals benefits to doing so. However, we hypothesize and experimentally find that the benefits of disaggregated forecasts do not necessarily carry over to the time of actual earnings announcements. Rather, disaggregated forecasts create multiple points of possible comparison between the forecast and the subsequent earnings announcement. Thus, when firms disaggregate forecasts and subsequently release disaggregated actual earnings numbers, investors reward firms that beat those multiple benchmarks, but punish firms that miss those multiple benchmarks. Thus, we show that issuing a disaggregated earnings forecast to achieve the associated benefits can backfire after the announcement of actual earnings. Our results have implications for researchers and firm managers.
Data Availability: Contact the authors.
Revisiting the (Mis)Pricing of Accruals
Authors: Lail Bradley , Lipe Robert C. , Yi Han S. 
Published: January 2019

ABSTRACT
Our paper examines inconsistent conclusions regarding the accrual anomaly and demonstrates the importance of aligning regression specifications with hypotheses. Richardson, Sloan, Soliman, and Tuna (2005) conclude that accruals are mispriced and the mispricing seems to increase as accrual reliability decreases. Barone and Magilke (2009) and Ball, Gerakos, Linnainmaa, and Nikolaev (2016) conclude that cash flows rather than accruals are mispriced. We show that the divergent conclusions come from misalignment between the null hypothesis and regression specification in Richardson et al. (2005). In addition, analysis of the contemporaneous relations between stock returns and components of earnings supports an initial underreaction to cash flows by investors. We fail to detect links between the reliability measures in Richardson et al. (2005) and investor behavior once we align the statistical tests with the null hypothesis. Our reexamination of prior findings benefits accounting academics, standard setters, and others interested in how investors use earnings components.
JEL Classifications: M41.
Data Availability: All data used in this study are publicly available from the sources identified in the text.