bluuebunny/crossref_metadata_2025_split huggingface dataset:
Maternal residential exposure to specific agricultural pesticide active ingredients and birth defects in a 2003–2005 North Carolina birth cohort
Authors: Rappazzo Kristen M. , Warren Joshua L. , Davalos Angel D. , Meyer Robert E. , Sanders Alison P. , Brownstein Naomi C. , Luben Thomas J. 
Published: December 2018

BackgroundPreviously we observed elevated odds ratios (ORs) for total pesticide exposure and 10 birth defects: three congenital heart defects and structural defects affecting the gastrointestinal, genitourinary and musculoskeletal systems. This analysis examines association of those defects with exposure to seven commonly applied pesticide active ingredients.MethodsCases were live‐born singleton infants from the North Carolina Birth Defects Monitoring Program linked to birth records for 2003–2005; noncases served as controls (total n = 304,906). Pesticide active ingredient exposure was assigned using a previously constructed metric based on crops within 500 m of residence, dates of pregnancy, and likely chemical application dates for each pesticide‐crop combination. ORs (95% CI) were estimated with logistic regression for categories of exposure compared to unexposed. Models were adjusted for maternal race/ethnicity, age at delivery, education, marital status, and smoking status.ResultsAssociations varied by birth defect and pesticide combinations. For example, hypospadias was positively associated with exposures to 2,4‐D (OR50th to <90th percentile: 1.39 [1.18, 1.64]), mepiquat (OR50th to <90th percentile: 1.10 [0.90, 1.34]), paraquat (OR50th to <90th: 1.14 [0.93, 1.39]), and pendimethalin (OR50th to <90th: 1.21 [1.01, 1.44]), but not S‐metolachlor (OR50th to <90th: 1.00 [0.81, 1.22]). Whereas atrial septal defects were positively associated with higher levels of exposure to glyphosate, cyhalothrin, S‐metolachlor, mepiquat, and pendimethalin (ORs ranged from 1.22 to 1.35 for 50th to <90th exposures, and 1.72 to 2.09 for >90th exposures); associations with paraquat were null or inconsistent (OR 50th to <90th: 1.05 (0.87, 1.27).ConclusionOur results suggest differing patterns of association for birth defects with residential exposure to seven pesticide active ingredients in North Carolina.
Resting‐state connectivity within and across neural circuits in anorexia nervosa
Authors: Uniacke Blair , Wang Yun , Biezonski Dominik , Sussman Tamara , Lee Seonjoo , Posner Jonathan , Steinglass Joanna 
Published: December 2018

AbstractIntroductionObsessional thoughts and ritualized eating behaviors are characteristic of Anorexia Nervosa (AN), leading to the common suggestion that the illness shares neurobiology with obsessive–compulsive disorder (OCD). Resting‐state functional connectivity MRI (rs‐fcMRI) is a measure of functional neural architecture. This longitudinal study examined functional connectivity in AN within the limbic cortico‐striato‐thalamo‐cortical (CSTC) loop, as well as in the salience network, the default mode network, and the executive control network (components of the triple network model of psychopathology).MethodsResting‐state functional connectivity MRI scans were collected in unmedicated female inpatients with AN (n = 25) and healthy controls (HC; n = 24). Individuals with AN were scanned before and after weight restoration and followed for one month after hospital discharge. HC were scanned twice over the same timeframe.ResultsUsing a seed‐based correlation approach, individuals with AN had increased connectivity within the limbic CSTC loop when underweight, only. There was no significant association between limbic CSTC connectivity and obsessive–compulsive symptoms or prognosis. Exploratory analyses of functional network connectivity within the triple network model showed reduced connectivity between the salience network and left executive control network among AN relative to HC. These abnormalities persisted following weight restoration.ConclusionsThe CSTC findings suggest that the neural underpinnings of obsessive–compulsive symptoms may differ from those of OCD. The inter‐network abnormalities warrant examination in relation to illness‐specific behaviors, namely abnormal eating behavior. This longitudinal study highlights the complexity of the neural underpinnings of AN.
Oxaliplatin regulates myeloid‐derived suppressor cell‐mediated immunosuppression via downregulation of nuclear factor‐κB signaling
Authors: Kim Na‐Rae , Kim Yeon‐Jeong 
Published: December 2018

AbstractMyeloid‐derived suppressor cells (MDSCs) represent one of the major types of immunoregulatory cells present under abnormal conditions, including cancer. These cells are characterized by their immature phenotype and suppressive effect on various immune effectors. In both human and mouse, there are two main subsets of MDSCs: polymorphonuclear (PMN)‐MDSCs and mononuclear (Mo)‐MDSCs. Thus, strategies to regulate MDSC‐mediated immunosuppression could result in the enhancement of anticancer immune responses. Oxaliplatin, a platinum‐based anticancer agent, is widely used in clinical settings. It is known to induce cell death by interfering with double‐stranded DNA and interrupting its replication and transcription. In this study, we found that oxaliplatin has the potential to regulate MDSC‐mediated immunosuppression in cancer. First, oxaliplatin selectively depleted MDSCs, especially Mo‐MDSCs, but only minimally affected T cells. In addition, sublethal doses of oxaliplatin eliminated the immunosuppressive capacity of MDSCs and induced the differentiation of MDSCs into mature cells. Oxaliplatin treatment diminished the expression of the immunosuppressive functional mediators arginase 1 (ARG1) and NADPH oxidase 2 (NOX2) in MDSCs, while an MDSC‐depleting agent, gemcitabine, did not downregulate these factors significantly. Oxaliplatin‐conditioned MDSCs had no tumor‐promoting activity in vivo. In addition, oxaliplatin modulated the intracellular NF‐κB signaling in MDSCs. Thus, oxaliplatin has the potential to be used as an immunoregulatory agent as well as a cytotoxic drug in cancer treatment.
Methamphetamine‐induced renal pseudovasculitis: Suspicion is the key
Authors: Chamarthi Gajapathiraju , Lee Loy Justin , Koratala Abhilash 
Published: December 2018

Key Clinical Message
It is important to recognize drug‐induced vasculitis as patients with true vasculitis often require immunosuppressive therapy and delay in treatment can result in significant mortality. Illicit drug use (specifically methamphetamine and cocaine) should be in the differential diagnosis of vasculitis as it typically resolves with cessation of the drug.
To Be or Not to be Temp? An Analysis of the Moderating Role of Motives for Accepting Temporary Employment
Authors: Lo Presti Alessandro , Callea Antonino , Pluviano Sara 
Published: December 2018

AbstractWe investigate the role of contract volition and motives for accepting temporary employment in the relationship between precariousness of life and negative psychological symptoms in a sample of 275 Italian temps. Results suggest that the negative effect of contract volition on negative psychological symptoms is partially mediated by precariousness of life. A moderated mediation model shows that specific motives moderate the negative effects of contract volition on precariousness of life, so that when contract volition is higher, workers with weaker motives feel less precarious. This study broadens our understanding of temporary employment outcomes by showing that the negative consequences of precariousness of life seem to be less troublesome among temporary workers with higher contract volition and lower motivation. © 2018 ASAC. Published by John Wiley & Sons, Ltd.
A comparison of anti‐arrhythmic efficacy of carvedilol vs metoprolol succinate in patients with implantable cardioverter‐defibrillators
Authors: Ayan Mohamed , Habash Fuad , Alqam Bilal , Gheith Zaid , Cross Michael , Vallurupalli Srikanth , Paydak Hakan 
Published: December 2018

BACKGROUNDThe effects of carvedilol and metoprolol succinate on appropriate and inappropriate implantable cardioverter defibrillator (ICD) therapy in patients with heart failure with reduced ejection fraction (HFrEF) are not fully understood.HYPOTHESISThe hypothesis of our study is possible carvedilol superiority over metoprolol in patients with ICD.METHODSAll patients with ICD registered to a single device clinic between 1/2012 and 6/2017 (n = 569) were identified. Patients with systolic heart failure (left ventricular ejection fraction ≤40%) treated with carvedilol vs metoprolol succinate were compared. Primary endpoint was difference in survival free of appropriate device therapy (shock or anti‐tachycardia pacing, ATP). Secondary endpoints were freedom from inappropriate therapy (shock or ATP) and all cause death.RESULTSA total of 225 patients were included in the analysis with median follow up of 57 months (IQR 33.7‐90). The 2 groups were comparable in the baseline characteristics. Carvedilol was superior to metoprolol succinate in improving survival free of appropriate ICD therapy (HR 0.42; 95% CI 0.24‐0.72, P = 0.01). This difference was driven by reduction in survival free of appropriate shocks (HR 0.30; 95% CI 0.15‐0.63, P = −0.01) while there was no significant difference in appropriate ATP (HR 0.55; 95% CI 0.28‐1.1, P = 0.12). There was no significant difference in time to inappropriate shocks (HR 1.02; 95% CI 0.19‐5.6, P = 0.97), inappropriate ATP (HR 0.93, OR 0.24‐3.5, p value 0.9) or all cause death (HR 0.8; 95% CI 0.42‐1.5, P = 0.52).CONCLUSIONSThis study suggests that carvedilol use was associated with improved survival free of appropriate ICD therapy compared to metoprolol succinate in patients with HFrEF.
Insulin resistance influences the impact of hypertension on left ventricular diastolic dysfunction in a community sample
Authors: Bamaiyi Adamu J. , Woodiwiss Angela J. , Peterson Vernice , Gomes Monica , Libhaber Carlos D. , Sareli Pinhas , Norton Gavin R. 
Published: December 2018

BackgroundAlthough obesity‐associated metabolic abnormalities (insulin resistance‐IR) may not play as marked a role in determining left ventricular (LV) diastolic dysfunction (DD) as hypertension, the impact of combinations of these risk factors on DD is unknown.HypothesisWe hypothesized that IR influences the impact of hypertension on DD.MethodsIn 704 randomly selected participants from a community sample with a high prevalence of hypertension (50.6%) and obesity (46.5%), we determined adiposity indices, IR from the homeostasis model (HOMA‐IR) and LV diastolic function using standard echocardiographic techniques.ResultsHOMA‐IR was independently associated with lateral wall e' and E/e' (P < 0.05 to P < 0.005) as well as a diagnosis of DD (P < 0.02). Importantly, however, an enhanced relationship between HOMA‐IR and E/e' in hypertensives (n = 356, partial r = 0.15, P < 0.005) as compared to normotensives (n = 348, partial r = 0.02 P = 0.75) was noted. Consequently, as compared to normotensives, with adjustments for confounders, hypertension was independently associated with DD only in those with the highest tertile of HOMA‐IR (odds ratio = 2.65, 95% confidence interval = 1.29‐5.42, P < 0.01), while in those with the lowest tertile of HOMA‐IR, hypertension failed to show a higher prevalence of DD (P = 0.22).ConclusionsInsulin resistance enhances the impact of hypertension on LV DD. Thus, DD is more likely to occur with the combination of hypertension and IR.
Fluoxetine delays the cognitive function decline and synaptic changes in a transgenic mouse model of early Alzheimer's disease
Authors: Zhou Chun‐ni , Chao Feng‐lei , Zhang Yi , Jiang Lin , Zhang Lei , Fan Jin‐hua , Wu Yong‐xin , Dou Xiao‐yun , Tang Yong 
Published: December 2018

AbstractAlzheimer's disease (AD) is a progressive neurodegenerative disorder associated with cognitive decline. Previous studies have reported that the syndrome of AD begins with subtle alterations in hippocampal synapses prior to frank neuronal degeneration. It has recently been reported that fluoxetine (FLX) shows positive effects on AD patients who have depression and anxiety. However, it is unclear whether FLX can affect the pathogenesis of AD mice in the early stage of AD. To address this question, 8‐month‐old male APP/PS1 double‐transgenic AD mice were administered a 10‐week course of FLX (10 mg/kg/day) injections. Then, spatial learning and memory were evaluated using a Morris water maze test. Immunohistological staining and an unbiased stereological method were used to estimate the total number of dendritic spine synapses in the hippocampus. We found that FLX significantly shortened the mean escape latencies of the 10‐month‐old mice; reduced the elevated levels of soluble Aβ40, Aβ42, and amyloid plaques in the hippocampus; and prevented the decrease in dendritic spine synapses and in postsynaptic protein PSD‐95 density in the dentate gyrus, CA1/2 and CA3 regions of the hippocampus. Our results indicate that reversing synaptic impairment might be considered a promising therapeutic approach for alleviating the cognitive deficits associated with early AD. Moreover, our results suggest that FLX may be a safe and effective drug for delaying the progress of AD, which might provide a starting point for further research into new preventative measures and treatments for AD.
Node‐Fusion: Topology‐aware virtual network embedding algorithm for repeatable virtual network mapping over substrate nodes
Authors: Wang Desheng , Zhang Weizhe , He Hui , Liu Chuanyi 
Published: December 2018

SummaryCloud computing has become a new Internet application model, where network virtualization is recognized as an important technology for allowing multiple heterogeneous virtual networks (VNs) to coexist on a shared substrate network (SN). As demands in cloud computing increase, the scale of VN greatly increases as well, and providing an end‐to‐end SN to embed VNs in terms of scale is difficult. To utilize SN resources fully, we devise a topology‐aware Node‐Fusion algorithm, which is different from the traditional virtual network embedding (VNE) algorithms, for repeatable VNE over substrate nodes problem. We rank the resource of nodes through a novel solution by considering the CPU and bandwidth of adjacent link capacity and the number of adjacent links of each node as resources, and rank a node on the basis of resources. Furthermore, we embed several virtual nodes into the same substrate node together in accordance with Node‐Fusion interconnection value during the node mapping process, which can greatly improve the success ratio of the subsequent link mapping phase. Evaluation results confirm that Node‐Fusion outperforms traditional classical heuristics (Link‐opt, Node‐opt, and ORSTA), which are modified to fit into our model, with regard to acceptance ratio, long‐term revenue, long‐term cost, and revenue‐cost ratio.
Bridging market demand, proactivity, and technology competence with eco‐innovations: The moderating role of innovation openness
Authors: Liao Yi‐Chuan , Tsai Kuen‐Hung 
Published: December 2018

AbstractThis study develops a contingency framework by drawing upon on the perspectives of resource‐based view, stakeholder, and open innovation to investigate how and when market demand, environmental proactivity, and technology competence affect a firm's decision on the scope of eco‐innovation. A sample composed of 1,717 service firms is utilized to test the hypotheses. A zero‐truncated negative binomial approach is adopted to analyze the data. The results reveal that innovation openness plays a significant moderating role in the influence of proactivity and technology competence on the scope of eco‐innovation. Specifically, environmental proactivity has a stronger effect on the scope of eco‐innovation under high levels of search breadth and depth. Moreover, technology competence has more influence on the scope of eco‐innovation under a high level of search breadth. In addition, the results reveal that market demand positively affects the scope of eco‐innovation.
Cross‐layer optimization for full‐duplex cognitive radio network with cooperative spectrum sensing
Authors: Li Haitao , Liu Changjun 
Published: December 2018

SummaryIn this paper, the cross‐layer optimal design of multihop ad hoc network employing full‐duplex cognitive radios (CRs) is investigated. Firstly, the analytical expressions of cooperative spectrum sensing performance for multihop CR networks over composite fading channels are derived. Then, the opportunistic throughput and transmit power of CRs are presented based on the derivation of false alarm and missed detection probability. Finally, a multiobjective optimization model is proposed to maximize the opportunistic throughputs and minimize the transmitting power. Simulation results indicate that Pareto optimal solution of sensing duration, decision threshold, and transmit power can be achieved by cross‐layer multiobjective optimization, it can balance the conflicts between different objective functions and reap the acceptable outcomes for multihop CR network.
D2D communications with subchannel reusing for throughput‐guaranteed relay selection in LTE
Authors: Kao Shang‐Juh , Luo Sin‐Yu , Kao Ming‐Tsung , Chang Fu‐Min 
Published: December 2018

SummaryUsing full‐duplex relaying in device‐to‐device (D2D) communication, spectrum efficiency can be further improved as compared with traditional half‐duplex relaying. Due to the increasing demands for more system capacities and higher data rate, a throughput‐guaranteed and power‐aware relay selection mechanism is essential so that services can be successfully accomplished within tolerable power consumption. It is also imperative to prevent cellular users from interfering and preserve resources for more users at the same time. In current paper, we proposed an efficient relay selection scheme with subchannel reusing. Using the nonconflict group discovery algorithm, firstly, we divided D2D pairs into different groups based on the neighbor lists of all the devices. The D2D pairs in the same group were considered nonconflictive. By building a matrix that represents the power consumption of D2D transmission peers through relays, we proposed a group‐oriented relay selection scheme based on the Hungarian method allowing subchannel reuse over relay‐assisted D2D networks. Applying this mechanism, different D2D pairs are able to transmit messages at the same subchannel, whenever they are in the same group. Better throughput and spectrum usage than currently available relay selection schemes without subchannel reusing can be obtained. Particularly, more D2D pairs in high dense networks can be accommodated, and spectrum resources can be better preserved. The simulation results showed that our proposed mechanism can improve the total throughput by up to 35% as compared with an existing relay selection scheme without subchannel reusing, called as PRS‐D2D, when most D2D pairs are in a few groups.
User centric three‐factor authentication protocol for cloud‐assisted wearable devices
Authors: Jiang Qi , Qian Yuanyuan , Ma Jianfeng , Ma Xindi , Cheng Qingfeng , Wei Fushan 
Published: December 2018

SummaryWearable devices, which provide the services of collecting personal data, monitoring health conditions, and so on, are widely used in many fields, ranging from sports to healthcare. Although wearable devices bring convenience to people's lives, they bring about significant security concerns, such as personal privacy disclosure and unauthorized access to wearable devices. To ensure the privacy and security of the sensitive data, it is critical to design an efficient authentication protocol suitable for wearable devices. Recently, Das et al proposed a lightweight authentication protocol, which achieves secure communication between the wearable device and the mobile terminal. However, we find that their protocol is vulnerable to offline password guessing attack and desynchronization attack. Therefore, we put forward a user centric three‐factor authentication scheme for wearable devices assisted by cloud server. Informal security analysis and formal analysis using ProVerif is executed to demonstrate that our protocol not only remedies the flaws of the protocol of Das et al but also meets desired security properties. Comparison with related schemes shows that our protocol satisfies security and usability simultaneously.
Imprint cytology of biphenotypic sinonasal sarcoma of the paranasal sinus: A case report
Authors: Sugita Shintaro , Kubo Terufumi , Aoyama Tomoyuki , Moriya Jun , Okuni Tsuyoshi , Wanibuchi Masahiko , Yamashita Ken , Onodera Maki , Tsujiwaki Mitsuhiro , Segawa Keiko , Sugawara Taro , Hasegawa Tadashi 
Published: December 2018

AbstractBiphenotypic sinonasal sarcoma (BSNS) is a rare low‐grade spindle cell sarcoma that predominantly affects middle‐aged women with multiple tumors in the sinonasal tract. BSNS shows biphenotypic expression of neural and myogenic markers on immunohistochemistry (IHC) with a specific chimeric PAX3‐MAML3 fusion. The cytological features of BSNS have so far not been reported. Here, we describe a case of BSNS including findings of imprint cytology, histology, IHC, and genetic analysis. A 30‐year‐old woman presented with a nodular tumor that completely occupied the ethmoid sinus. The tumor was resected and submitted for imprint cytology, which revealed relatively bland spindle tumor cells that had mildly enlarged oval to spindle‐shaped nuclei with fine nuclear chromatin and a thin nuclear rim in a clear background. Nucleoli were inconspicuous and there was no significant nuclear atypia and pleomorphism. These cytological findings were consistent with the histology of low‐grade spindle cell sarcoma in BSNS. On IHC, the tumor cells were focally positive for S‐100 protein and α‐smooth muscle actin; nuclear β‐catenin expression was also seen. PAX3 split signals were detected in 52% of tumor cells by fluorescence in situ hybridization. Reverse transcriptase‐polymerase chain reaction also identified a chimeric PAX3‐MAML3 fusion gene. Based on these findings, we diagnosed the tumor as BSNS. Our findings revealed that a relatively bland spindle cell cytology with a clear background is a characteristic feature of BSNS. BSNS should therefore be differentiated from benign and bland‐appearing malignant spindle cell tumors and the combination of cytology, histology, IHC, and genetic analysis facilitates the diagnosis of BSNS.
Factors that affect transfer swing period in mutual smoothing effect of RE output fluctuation
Authors: Komami Shintaro , Jozuka Takeshi 
Published: December 2018

AbstractAlthough output of individual RE (Renewable Energy) such as PV (Photovoltaic Generation) severely varies, total output of many REs locate with geographical diversity is considerably smoothed out. The phenomenon is well known and is called as (mutual) smoothing effect. To quantitatively and mathematically express it, a theory named “Transfer Hypothesis” using “Transfer Swing Period Tx” as an important parameter is presented. Since the theory regards the effect as a kind of low pass filter, the theory can be applied to not only spectrum on frequency axis but also time sequential data. However, whole view of factors that affect Tx is not made clear yet. Therefore, it is questionable that once identified Tx in the studied area can be always adequate for practical use. The paper verifies the adequacy. Seasonal factors such as month and week, impact by number of sites in the studied area, and geographical factors such as distance between neighboring sites and studied area's size are examined. It has been demonstrated that Tx of two sites strongly depends on their distance, that number of sites does not affect Tx, and that Tx of the studied area is equal to that of two sites separated a distance 1/3 the length of the studied area. Therefore, it has been found that long time measurement on many sites is not necessary to identify Tx.