bluuebunny/crossref_metadata_2025_split huggingface dataset:
A recepção crítica do romance O Coruja, de Aluísio Azevedo
Authors: Viana Maria 
Published: January 2019

De maneira geral, costuma-se agrupar a obra de Aluísio Azevedo em dois segmentos. De um lado, ficariam obras de indiscutível qualidade literária, caso de O cortiço, Casa de pensão e O Mulato; de outro, os livros destinados às folhas matutinas e, portanto, escritos para atender à demanda dos leitores de jornais. Essa divisão contribuiu para que grande parte dos romances desse escritor, despertasse pouco interesse de estudo por parte da crítica. No caso da obra O Coruja, alguns críticos a condenam; outros consideram suas qualidades, mas lamentam o fato de o romance ter sido escrito apressadamente para ser publicado como folhetim. Por isso, achamos relevante apresentar neste artigo breve explanação sobre a recepção da obra de Aluísio Azevedo, com destaque para o romance O Coruja. *** The critical reception of the novel O Coruja, by Aluísio Azevedo ***In general, it is customary to organize the novels of Aluísio Azevedo into two segments. On the one hand, they would be books of indisputable literary quality (O cortiço, O homem and O mulato); on the other, the books written for the morning paper and, therefore, written to meet the demands of newspaper readers. That division contributed to some novels by Aluísio Azevedo are little studied. In the case of book O Coruja, some critics condemn; others critics consider their qualities, but they talk the fact that novel be written hastily, for be published in serial. Therefore, we present in this article relevant brief xplanation about the reception of the work of Aluísio Azevedo, especially the novel O Coruja.Keywords: Aluísio Azevedo; O Coruja; Critical fortune.
L’ethos discursif
Authors: Di Fanti Maria Da Glória Corrêa , Feré Liz 
Published: January 2019

La notion d’ethos discursif a été l’objet de différentes recherches portant sur l’image de l’énonciateur produite par le discours. Cette image, selon Maingueneau (2005, 2006, 2008, 2014), se construit dans les discours à travers ses multiples relations avec l’autre (sujets et discours) et se dégage de l’articulation entre divers éléments (éthiques, esthétiques, psychiques), qui ont besoin de l'incorporation de l'interlocuteur pour l'appréhender dans un ensemble complexe de représentations sociales et culturelles[1].[1] Une partie des idées sur l’ethos ont été développées dans l’article Identidade, alteridade e cultura regional: a construção do ethos milongueiro gaúcho (DI FANTI, 2009).
Análisis de la corrupción a nivel internacional y su relación con los costos asociados en la gestión de los negocios
Authors: Briseño-Ramírez Hugo , Rubiano-Moreno Jessica , Rodríguez-Magaña Alejandro 
Published: January 2019

En el siguiente trabajo se busca probar la hipótesis según la cual la corrupción es fruto del alto costo de la legalidad, al obstaculizar la agilidad para hacer negocios.Se realiza un modelo econométrico con una muestra de 43 países, en el que la variable dependiente es el índice de corrupción, y las variables independientes o explicativas son un índice de costo de la legalidad —compuesto a su vez por cinco indicadores—, y una variable asociada al ingreso. Ambas resultan significativas, tal como lo sugiere la teoría.En conclusión, la corrupción es resultado del excesivo costo de la legalidad y del bajo nivel de ingreso.
Políticas de Financiamiento: Apoyos Financieros Federales Financing Policies: Federal Financial Support
Authors: Medina Sauza Ana Lilia , Acosta Márquez Maria Pilar , López Fernández Eira 
Published: January 2019

La Secretaría de Economía (SE) con el fin de promover el crecimiento de las empresas tanto para aquellas que inician sus actividades como para las que ya están constituidas, ha desarrollado programas de apoyo financiero, mismos que ofrece al público en general para fines específicos de acuerdo al tipo de empresa.
En el presente trabajo se estudia a una persona física que adquiere un apoyo financiero federal obtenido a través del Instituto Nacional del Emprendedor, órgano administrativo desconcentrado de la SE, que dedica su esfuerzo a brindar apoyo financiero a las empresas. Dicho estudio se lleva a cabo para estimar el efecto fiscal a partir del ingreso recibido como apoyo.
Minimally invasive surgical treatment of a patient with pathological tortuosity of the carotid artery using endoscopic assistance
Authors: Lukyanchikov V. A. , Khasauov R. Kh. , Kozhaev Z. U. , Gekkieva Zh. S. , Krylov V. V. , Vinogradov R. A. 
Published: January 2019

The study objective is to describe a clinical case of surgical treatment of a patient with pathological distal tortuosity of the left internal carotid artery (ICA) and present a comprehensive description of a proposed surgical technique, as well as compare advantages and disadvantages of the chosen and alternative surgery types.Materials and methods. At the 1st stage, we performed computed angiography and triplex scanning of the main head arteries and modelled operative approach. At the 2nd stage, we mapped the ICA approach, redressing and resection. At the 3rd stage, using endoscopic assistance we separated the ICA along its entire length, found its pathological kink, performed ICA redressing and resection with subsequent reanastomosis with high accuracy and minimal injury.Results. ICAblood flow was 320 ml/min (prior to surgery: 140 ml/min). In the postoperative period, positive dynamics of the patient’s neurological status were observed. Computed angiography and triplex scanning confirmed removal of pathological tortuosity. Compared to the proposed technique, other surgery types (open access) are characterized by high risk of injury of the cranial nerve branches, submandibular and parotid glands, necessity of dissection of the digastric, stylohyoid muscles, subluxation of the mandibula, etc.Conclusion. The method of allocation of hard to reach tortuosities of the carotid artery developed based on previously known endoscopic manipulations on the vessels of the extremities using endoscopic assistance allows to decrease injury during the intervention and achieve maximal technical and clinical effect.
The necessity and advantages of personified neck lymph node dissection in T1-2N0M0 oral mucosa cancer. A pathway to radical surgery
Authors: Margolin G. , Mudunov A. М. , Gelfand I. M. , Alymov Yu. V. , Akhundov A. A. , Podvyaznikov S. О. , Narimanov M. N. , Zabotina T. N. , Zakharova E. N. 
Published: January 2019

The study objectiveis to investigate the causes of insufficient efficiency of neck lymph node dissection and possibilities of its improvement in cancer of the oral mucosa without clinically detectable metastases.Materials and methods.A review of literature on surgical methods of affecting regional lymph collectors in cancers of the oral cavity was performed, and preliminary data on possibilities of biopsy of the sentinel lymph node were obtained.Conclusion.Combination of fluorescent lymph node mapping andflow cytometry allows to identify the sentinel lymph node and detect hidden micrometastases with high sensitivity.
Prevalence of virus-associated cancer of the nasal cavity and paranasal sinuses in the Arkhangelsk Region
Authors: Vereschagin M. Yu. , Minkin A. U. , Makarova M. V. 
Published: January 2019

The study objective is to evaluate the prevalence of Epstein—Barr virus (EBV), herpes virus, human papillomavirus (HPV), and cytomegalovirus (CMV) infection among patients with cancer of the nasal cavity and paranasal sinuses in the Arkhangelsk Region.Materials and methods. We examined surgical specimens from 100 patients treated in the Arkhangelsk Clinical Oncology Dispensary between 2010 and 2015. Tissue homogenates were used for DNA isolation. DNA amplification with subsequent detection was performed using polymerase chain reaction.Results and conclusion. The 36 % of study participants were infected with EBV; the second most common viral pathogens were CMV and human herpes virus type 6 (HHV-6), both found in 21 % of cases. Monoinfection was observed in less than one-third of patients (20 % — EBV, HPV type 16 — 6 %), whereas the remaining participants had mixed infections: EBV + HHV-6 (2 %), CMV + EBV (5 %), EBV + herpes simplex virus types 1 and 2 (HSV-1,2) (1 %), EBV + CMV + HHV-6 (3 %), HPV type 16 + HSV-1,2 (3 %), and HPV type 6 + HPV type 16 (7 %). None of the patients with stage I cancer had mixed infections, whereas participants with stage II, III, and IV cancer demonstrated mixed infections in 1 %, 11 %, and 9 % of cases respectively.After specific treatment, 11 patients (30.5 %) infected with EBV developed regional metastases and 5 patients (13.9 %) had relapses. All patients simultaneously infected with EBV and HHV-6 had distant metastases. Combination of EBV, CMV, and HHV-6 resulted in relapses in 100 % of cases and distant metastasis in 75 % of cases.
ANALYSIS OF SPONTANEOUS REPORTS OF ADVERSE REACTIONS IN PATIENTS WITH CORONARY ARTERY DISEASE IN THE REPUBLIC OF CRIMEA
Authors: Matveev O. V. , Krasheninnikov A. E. , Kiseleva N. M. , Egorova E. A. , Dormidor A. G. 
Published: January 2019

Aim. To analyze spontaneous reports of adverse drug reactions in patients with coronary artery disease in the Republic of Crimea for the fve-year period from January 2011 to August 2016.Methods. 332 reports of adverse drug reactions in patients with coronary artery disease collected in the “ARCADe” database were analyzed. Out of them, 231 reports on essential drugs affecting the cardiovascular system were selected. The age of patients who reported adverse drug reactions ranged from 37 to 90 years.Results. The rate of adverse drug reaction reports increased with patients’ aging, reaching its maximum (31.6% of all drug reaction reports) by 70–80 years. The incidence of adverse reactions was higher among women (63.6%), which is generally consistent with other studies. However, men receiving nitrates had a 3.4-fold increase in the rate of adverse drug reactions compared to women. The highest rate of adverse drug reactions was associated with ACE inhibitors (29.0%), and in particular Enalapril, which is probably explained by a higher rate of their prescriptions, compared to other drugs.Conclusion. Most of the reported adverse drug reactions were expected. The frequent development of allergic reactions (16% out of all adverse reactions in this study) in patients with coronary artery disease were associated with ACE inhibitors, betablockers and antithrombotic agents.
Regarding the subject of degradation of femoral medial condyle cartilaginous tissue in damaged knee joint medial meniscus
Authors: Denisov A. S. , Zagorak D. P. 
Published: January 2019

Aim. To reveal the influence of patient’s connective tissue state and body mass on the development of damage of the cartilaginous tissue of femoral bone medial condyle in case of medial meniscus rupture.
Materials and methods. The study included 85 patients, undergoing arthroscopic treatment of the knee joint in connection with damaged medial meniscus. The damage degree of femoral medial condyle cartilaginous tissue was estimated using Outerbridge classification (1961). The body mass was calculated by the body mass index kg/m2. To assess the connective tissue elasticity, “the method of express diagnosis of dysplastic state of connective-tissue structures in conditions of ambulatory traumatologo-orthopedic service” was used.
Results. The present paper is devoted to a widespread problem – the damage of femoral medial condyle cartilaginous tissue in case of medial meniscus rupture. The aim of the study was to find out the influence of connective tissue state and body mass on the damage of the femoral medial condyle cartilaginous tissue. Seventy patients were examined. As a result of analysis, it was established that an excess body mass as well as low connective tissue elasticity provoke destruction of the cartilaginous tissue of femoral bone medial condyle. Patients with connective tissue dysplasia are more tolerant to cartilaginous tissue degradation. The risk group for cartilaginous tissue damage includes persons with low connective tissue elasticity and obesity.
Conclusions. When medial meniscus is ruptured, most patients during the first 6 months after trauma experience damage of femoral medial condyle cartilaginous tissue. The most favorable for the outcome is the state when patients have a normal body mass. Dysplastic state of connective tissue somehow eliminates the damaging factor at the expense of elevated elasticity of cartilaginous tissue. The most unfavorable is the situation, when patients have excess body mass and low connective tissue elasticity. For this group of patients the most optimal variant is hospitalization and arthroscopic treatment taking into account urgent indications.
Changed content of heat shock proteins and antibodies to them in blood and nasal mucosa cells in rhinites and rhinosinusites of different etiology
Authors: Ivanov M. O. , Ivanova N. M. , Maksimenya M. V. , Karavaeva T. M. , Egorova E. V. , Fefelova E. V. , Tsybikov N. N. 
Published: January 2019

Aim. To determine the content of heat shock proteins with molecular weight 70 kDa (HSP 70) and antibo dies to them in blood and nasal secretion in patients with allergic rhinites and infectious rhinosinusites of different etiology.
Materials and methods. The paper presents the results of examination of 10 patients with allergic rhinitis and 30 patients, infected with rhinosinusites(the age range 25–35 years). The patients with infectious rhinosinusites were divided into 3 groups according to nosologic form of disease. The control group included 10 practically healthy persons in the ratio, comparable by their gender and age with sick persons.
Results.The analysis showed that in the nasal secretion of all patients, HSP 70 level significantly raised compared to the control. Maximum values were registered in patients with bacterial rhinosinusitis and were higher than in patients with viral and fungous ones by 1.9 times (p = 0.015) and 2.9 times (p = 0.001), respectively. In blood serum, HSP 70 concentration compared with the control increased in patients with allergic rhinitis and bacterial rhinosinusitis by 103.67 % (p = 0.015) and 32.11 % (p = 0.049), respectively; these values in the last two groups exceeded the latter in patients with fungous RS by 2.37 times (p = 0.01) and by 1.54 times (p = 0.035).
Conclusions. It was detected that in the group of patients with allergic rhinitis and chronic bacterial rhinosinusitis in the nasal secretion and blood serum, HSP 70 values were the highest. In the nasal secretion, HSP 70 level was higher than in blood. The amount of autoantibodies to HSP 70 in blood grew in allergic rhinitis, fungous and viral forms of rhinosinusites that reflects the immunological effect of chaperone proteins.
Characteristics of adaptive responses and status of newborns depending on degree of parturient genital colonization with Ur. Urealyticum
Authors: Melnikova T. A. , Padrul M. M. , Gorovits E. S. , Rabotnikova G. I. 
Published: January 2019

Aim. To study the characteristic features of newborn status depending on the level of parturient genital colonization with Ur. urealyticum.
Materials and methods. The characteristic features of newborns’ status were studied in 112 puerperas, who by the results of repeated microbiological examination for ureaplasmosis, in the period of 30–34 weeks of pregnancy were divided into 3 groups: group I included 38 persons with negative results of PCR and bacteriology; group II (risk) joined 39 women, infected with Ur. urealyticum to 104 CFU/ml and PCR 5·104 DNA copies per ml; and group III – 35 pregnant women with bacterial inoculation less than 104 CFU/ml. The comparison group – 40 pregnant women, uninfected with ureaplasmas when examined for the first time.
Results. In newborn children from puerperas of risk group, Apgar scores at 1 and 5 minutes were statistically significantly lower, than in children, born from mothers of the other groups. In this group, birth of premature newborns and those with hypotrophy as well as newborns with fetal development retardation syndrome were registered significantly more often. Perinatal encephalopathy was detected in 50.0 % of newborns. When discharged from maternal home, nearly a half of infants from this group had no the initially required body mass, but in the other groups there were 2–2.5 times more such newborns.
Conclusions. Newborns from mothers infected with Ur. Urealyticum in high, etiologically significant titers, are characterized by decrease in adaptive responses that is proved by Apgar scores and by retarded body mass growth after birth. High level of parturient genital colonization with Ur. urealyticum has a negative effect on the newborns’ health status. Low, etiologically insignificant Ur. urealyticum titers in mothers practically don’t influence the newborns’ health status.
Congenital Infantile Fibrosarcoma of the Tongue: Case Report and Review of the Literature
Authors: Lee Francis , Ha Jennifer , Vijayasekaran Shyan 
Published: January 2019

Introduction: Congenital infantile fibrosarcoma is often misdiagnosed. It may be more common than noted in the literature. We present an unusual case of paediatric head and neck fibrosarcoma.
Methods: Restrospective case report and literature review.
Results: We report the surgical management of a fibrosarcoma of the tongue in an 8-month-old child where neo-adjuvant chemotherapy was unsuccessful.
Conclusion: Surgical resection is the mainstay of treatment, in the head and neck region where critical structures are close to the tumour, complete resection with wide margins can be difficult. The role of chemotherapy is yet to be defined.
Iguratimod, A Synthetic Disease Modifying Anti- Rheumatic Drug (Sdmard), and Various Dmards Suppress Joint Destruction. The Pathophysiological Mechanisms of the Inhibition of Bone/Cartilage Destruction
Authors: Ishikawa Koichiro , Ishikawa Junichiro 
Published: January 2019

Objective: To elucidate the radiographic outcomes for rheumatoid arthritis (RA) patients using the synthetic disease-modifying antirheumatic drug (sDMARD) Iguratimod (IGU) and other DMARDs including injectable sodium aurothiomalate, bucillamine, salazosulphapyridine, infliximab, etanercept, tocilizumab and/or abatacept.Patients and Methods: 213 patients were enrolled in this study. Total Genant-modified Sharp scores (GSS) of hands/wrists and feet at baseline and at week 104 were calculated in 31 RA patients treated with a daily dose of 25 mg or 50 mg for 104 weeks.Results: Total GSS of 31 patients at week 104 showed no progression (total GSS <= 0.84: the smallest detectable change) in 16 (52%) patients with a mean score reduction (95% CI) of-4.3 (-8.1 ~ -0.5) (p < 0.05).Conclusion: Treatment with the sDMARD, IGU showed no radiographic progression in 16 (52%) RA patients at week 104. Concerning the suppression mechanism of joint destruction by IGU and other DMARDs, we speculate that DMARDs prevent bone/cartilage destruction by inhibiting the receptor activator of nuclear factor-kappa B (NF- kB) lig and (RANKL) and through other antirheumatic actions.
Sintesis Lapis Tipis Zn1-XNiXO sebagai Material Fotokatalis Pendegradasi Pewarna Tekstil
Authors: Roziqin Achmad Zainur , Haryati Tanti , Andarini Novita 
Published: January 2019

Limbah cair zat warna dapat didegradasi dengan menggunakan teknik fotodegradasi katalitik menggunakan material semikonduktor dengan bantuan paparan sinar ultraviolet (UV). Salah satu material semikonduktor yang digunakan untuk proses pendegradasian adalah zink oksida (ZnO). Metode sintesis lapis tipis Zn1-xNixO adalah sistem deposisi larutan. Pengaruh dari variasi jumlah penambahan ion dopan Ni 2+ pada sintesis lapis tipis Zn1-xNixO terhadap struktur dan komposisi dikarakterisasi menggunakan X-Ray Diffraction (XRD) dan X-Ray Fluoresence (XRF). Kinerja dari lapis tipis Zn1-xNixO sebagai fotokatalitik dipelajari melalui % degradasi limbah zat cair dalam hal ini menggunakan Procion Red MX8-B. Berdasarkan hasil karakterisasi diperoleh hasil semakin tinggi persentase ion dopan Ni2+ maka semakin tinggi kristanilitas dan semakin kecil ukuran kristal dari lapis tipis Zn1-xNixO. Begitu pula pada aktivitas fotokatalisnya semakin tinggi persentase ion dopan Ni2+ maka semakin tinggi pula persen degradasinya. Aktivitas fotokatalis optimum didapatkan pada lapis tipis dengan komposisi 5% Ni yaitu sebesar 34.5%. Kata Kunci: Lapis tipis Zn1-xNixO, fotodegradasi katalitik, limbah cair zat warna.
HEALTH FACILITIES LOCATIONAL ANALYSIS IN MAKURDI LOCAL GOVERNMENT AREA OF BENUE STATE-NIGERIA USING GIS APPLICATION
Authors: Okosun Oboh Satur 
Published: January 2019

The most important indices of defining general welfare and quality of life of people in the world are the physical and mental health of individuals. This study attempts to examine GIS solution in the spatial analysis of health facilities in Makurdi local government area of Benue State, through mapping of the existing health facilities located in the study area, their spatial distribution pattern, identify areas with marginal services and propose a model for the future development as well examine the availability and accessibility of the existing health facilities, e.g (road network, travel time, distance covered and queuing time). The” Nearest neighbour analysis” Geospatial statistical method was employed to determine the spatial distribution pattern of the existing health facilities in other to determine the area of limited service and accessibility to healthcare facilities. The findings indicated that the healthcare facilities are randomly distributed; Fiidi ward was discovered to have limited service as regards the healthcare facilities in the study area. In line with the findings, recommendations were made on the use of GIS to build a concept that can be followed and replicated in divergent social-economic and political contexts. Conclusively, the study had shown that GIS is a vital tool in healthcare facility analysis and also in live application issues and thus should be encouraged in Nigeria for national economic transformation and sustainable development.

keywords: Health, GIS, Mapping, Location
Rendemen dan Flavonoid Total Ekstrak Etanol Kulit Batang Bangkal (Nauclea subdita) dengan Metode Maserasi Ultrasonikasi
Authors: Sari Destria Indah , Triyasmono Liling 
Published: January 2019

ABSTRAK

Penggunaan jenis dan konsentrasi pelarut ekstraksi merupakan beberapa hal yang dapat mempengaruhi jumlah rendemen dan kandungan metabolit sekunder suatu ekstrak. Bangkal (Nauclea subdita) merupakan salah satu tumbuhan di Kalimantan Selatan, dan bagian kulit batangnya sering dimanfaatkan oleh masyarakat setempat untuk mengatasi pengaruh buruk sinar matahari. Penelitian ini bertujuan untuk menentukan rendemen dan kandungan flavonoid total dalam ekstrak etanol kulit batang bangkal dengan metode maserasi ultrasonikasi. Konsentrasi pelarut etanol divariasikan menjadi 30%, 50%, 70%, dan 96%. Hasil rendemen yang diperoleh untuk masing-masing konsentrasi tersebut yaitu 2,60%; 1,88%; 1;88%; 1,92%. Sedangkan total flavonoid yang diperoleh dari dua replikasi sebesar 12,329 ± 0,251 EK, 8,865 ± 0,058 EK, 18,012 ± 0,461 EK, dan 44,728 ± 2,525 EK.

Kata kunci	: bangkal (Nauclea subdita), rendemen, flavonoid total, maserasi ultrasonikasi

ABSTRACT

Solvent type and concentration were some factors that could effect extract yield and secondary metabolites content. Bangkal (Nauclea subdita) were one of the plant on South Kalimantan, and its bark were used to treat sunrays negative effect. This research was aimed to determined extract yield and total flavonoid content using ultrasonicated maceration methode. Ethanol concentration were varied to 30%, 50%, 70%, and 96%. Yield obtained from those concentrations were 2.06% , 1.88%, 1.88%, and 1.92%, respectively. While total flavonoid content obtained from conducted in duplication were 12.329 ± 0.251 QE, 8.865 ± 0.058 QE, 18.012 ± 0.461 QE, and 44.728 ± 2.525 QE, respectively.

Keywords: Nauclea subdita, extract yield, total flavonoid, ultrasonicated maceration.