bluuebunny/crossref_metadata_2025_split huggingface dataset:
Making her end of life her own: further reflections on supporting a loved one with motor neurone disease
Authors: Harris Denise Andrea , Jack Kirsten , Wibberley Christopher 
Published: June 2019

Background: People can live for many months without knowing why their body is failing prematurely before being diagnosed with motor neurone disease (MND); a terminal neurodegenerative disease which can be experienced as ‘devastating’ for the person and their family. Aim: This study aimed to explore the meaning of supporting a loved one with MND to die. Methods: This study uses reflection and autobiographical story to connect with broader cultural, political and social meaning and understandings of dying. Findings: Four themes were identified relating to the end-of-life trajectory of MND. Loss of person (lived body experienced in silence); loss of relationships (lived relations are challenged); loss of home and loss of time (lived space and lived time take on new meaning); loss of future (dying—facing it alone). Conclusion: Dying with MND is a complex phenomenon. When a person can no longer move and communicate, relationships between those involved in end-of-life care are challenging. A person with MND needs the support from those acting as power of attorney to make their end of life their own, and they themselves need support to find meaning in their suffering. This autoethnographic reflection provides vicarious experiences for nurses and other healthcare professionals working with people with MND and similar conditions.
Validation of Risk Scoring Systems in Ursodeoxycholic Acid–Treated Patients With Primary Biliary Cholangitis
Authors: Efe Cumali , Taşçilar Koray , Henriksson Ida , Lytvyak Ellina , Alalkim Fatema , Trivedi Hirsh , Eren Fatih , Eliasson Johanna , Beretta‐Piccoli Benedetta Terziroli , Fischer Janett , Calişkan Ali Riza , Chayanupatkul Maneerat , Coppo Claudia , Ytting Henriette , Purnak Tugrul , Muratori Luigi , Werner Mårten , Muratori Paolo , Rorsman Fredrik , Önnerhag Kristina , Günşar Fulya , Nilsson Emma , Heurgué-Berlot Alexandra , Güzelbulut Fatih , Demir Nurhan , Gönen Can , Semela David , Aladağ Murat , Kiyici Murat , Schiano Thomas D. , Montano-Loza Aldo J. , Berg Thomas , Ozaslan Ersan , Yoshida Eric M. , Bonder Alan , Marschall Hanns-Ulrich , Wahlin Staffan 
Published: June 2019

INTRODUCTION:
Risk stratification based on biochemical variables is a useful tool for monitoring ursodeoxycholic acid (UDCA)-treated patients with primary biliary cholangitis (PBC). Several UDCA response criteria and scoring systems have been proposed for risk prediction in PBC, but these have not been validated in large external cohorts.

METHODS:
We performed a study on data of 1746 UDCA-treated patients with PBC from 25 centers in Europe, United States, and Canada. The prognostic performance of the risk scoring systems (GLOBE and UK-PBC) and the UDCA response criteria (Barcelona, Paris I, Paris II, Rotterdam, and Toronto) were evaluated. We regarded cirrhosis-related complications (ascites, variceal bleeding, and/or hepatic encephalopathy) as clinical end points.

RESULTS:
A total of 171 patients reached a clinical end point during a median 7 years (range 1–16 years) of follow-up. The 5-, 10- and 15-year adverse outcome–free survivals were 95%, 85%, and 77%. The GLOBE and UK-PBC scores predicted cirrhosis-related complications better than the UDCA response criteria. The hazard ratio (HR) for a 1 standard deviation increase was HR 5.05 (95% confidence interval (CI): 4.43–5.74, P < 0.001) for the GLOBE score and HR 3.39 (95% CI: 3.10–3.72, P < 0.001) for the UK-PBC score. Overall, the GLOBE and UK-PBC risk scores showed similar and excellent prognostic performance (C-statistic, 0.93; 95% CI: 0.91%–95% vs 0.94; 95% CI: 0.91%–0.96%).

DISCUSSION:
In our international, multicenter PBC cohort, the GLOBE and UK-PBC risk scoring systems were good predictors of future cirrhosis-related complications.
More than just friends: in-home use and design recommendations for sensing socially assistive robots (SARs) by older adults with depression
Authors: Randall Natasha , Bennett Casey C. , Šabanović Selma , Nagata Shinichi , Eldridge Lori , Collins Sawyer , Piatt Jennifer A. 
Published: June 2019

Abstract
As healthcare turns its focus to preventative community-based interventions, there is increasing interest in using in-home technology to support this goal. This study evaluates the design and use of socially assistive robots (SARs) and sensors as in-home therapeutic support for older adults with depression. The seal-like SAR Paro, along with onboard and wearable sensors, was placed in the homes of 10 older adults diagnosed with clinical depression for one month. Design workshops were conducted before and after the in-home implementation with participating older adults and clinical care staff members. Workshops showed older adults and clinicians sawseveral potential uses for robots and sensors to support in-home depression care. Long-term in-home use of the robot allowed researchers and participants to situate desired robot features in specific practices and experiences of daily life, and some user requests for functionality changed due to extended use. Sensor data showed that participants’ attitudes toward and intention to use the robot were strongly correlated with particular Circadian patterns (afternoon and evening) of robot use. Sensor data also showed that those without pets interacted with Paro significantly more than those with pets, and survey data showed they had more positive attitudes toward the SAR. Companionship, while a desired capability, emerged as insufficient to engage many older adults in long-term use of SARs in their home.
Between the institution and the individual: What walking in a place that includes institutional heritage discloses
Authors: Argaman Einav 
Published: June 2019

AbstractThis article discusses the ways in which “walking” in a place that exhibits institutional heritage (albeit is not set as a separate gallery) discloses individuality within institutional/hegemonic intent. Examining photographs taken in a place that,among other activities, comprises institutional heritage, the article adds to the literature by specifying a new mode of walking in heritage “sites.” Walking is regarded a semiotic resource; hence, the article’s insights relate to: (a) arguments in the institution, (b) definitions of “center,” (c) “attractors” in retailing and museums (as places which present heritage), and (d) the architecture of paths. The final section of the article considers heritage ineducationalinstitutions (the specific environment that the article discusses). It relates to the characteristics of classroom talk and offers recommendations for incorporating them in exhibitions dedicated to the heritage of education institutions, as a means to establish teachers’ professional identity.
Relationships Among Circuit Training, Small-Sided and Mini Goal Games, and Competition in Professional Soccer Players: A Comparison of On-Field Integrated Training Routines
Authors: Giménez Jesús V. , Gomez Miguel A. 
Published: June 2019

Abstract
Giménez, JV and Gomez, MA. Relationships among circuit training, small-sided and mini goal games, and competition in professional soccer players: A comparison of on-field integrated training routines. J Strength Cond Res 33(7): 1887–1896, 2019—The aim of this study was to investigate and compare different physical variables and load indicators of 2 small-sided game (SSG) formats and ball circuit training (CT). Fourteen professional players participated in 3 training routines using a similar occupied area per player (90 m2). The CT, SSGs, and mini goal games (MGs) consisted of 8 repetitions of 4-minute game play, interspersed by 2 minutes of active recovery, and data were compared with the first 32 minutes of 2 competitive match simulations (MS). All movement patterns from walking to sprinting were recorded using 10-Hz global positioning system devices, whereas player perception of exertion was recorded after trial using a visual analogue scale. Practical differences among the 3 drills and MS were analyzed using magnitude-based inferences. The results suggested that the training routines did not exactly replicate the movement patterns of a competitive match. Furthermore, this study provides evidence that if high-intensity play is preferred, then SSGs should be emphasized (because they provide more total accelerations compared with the other drills; most likely effects). Moreover, the CT showed lower load and distance covered (m) than the MGs and SSGs. In conclusion, these drills may be useful for competition and impact microcycles (i.e., intermittent efforts with accelerations, decelerations, and walking actions) to achieve the specific adaptations of high-intensity efforts.
TÜKETİCİLERİN AKILCI İLAÇ KULLANIMINA YÖNELİK BİLGİ DÜZEYLERİ VE DAVRANIŞLARINI ETKİLEYEN FAKTÖRLERİN DEĞERLENDİRİLMESİ: SİVAS İLİ ÖRNEĞİ
Authors: ERCAN Tolgay , BİÇER Derya Fatma 
Published: June 2019

Tüketicinin satın alma davranışı bir ihtiyacının giderilmesinden kaynaklanmaktadır. Satın alma sürecini gerçekleştiren tüketici, güçlü tutumları ile bu davranışı ortaya koymaktadır. Akılcı ilaç kullanımı, öncelikli olarak halk sağlığını ve toplumun çıkarını gözetmektedir. İnsanların ilaçlara kolay bir şekilde ulaşabilmeleri, ilaçlar hakkındaki yetersiz bilgiye sahip olmaları veya ilaç kullanımlarındaki davranış problemlerinden kaynaklı günümüzde yanlış ilaç kullanımları artmış bunun sonucunda zararlı yan etkiler de ortaya çıkmıştır. Bu çalışma akılcı ilaç kullanımında Sivas ili tüketicilerinin bilgi düzeyleri ve davranışlarını etkileyen faktörler arasında anlamlılık olup olmadığını araştırmak amacıyla yapılmıştır. Anket çalışmaları yaz ve kış mevsimleri olmak üzere iki dönemde ve 463 kişi ile gerçekleştirilmiştir. Çalışmadan elde edilen bulgulara göre; katılımcıların medeni halleri, cinsiyetleri, eğitim durumlarındaki ilerleme, meslek gruplarının farklılığı, yaş aldıkça sergiledikleri davranışlar istatiksel olarak anlamlı olduğu, anket yapılan tüketicilerin büyük çoğunluğunun akılcı ilaç kullanım ilkeleri doğrultusunda davranış sergiledikleri sonucuna ulaşılmıştır.
Social Robots for Hospitalized Children
Authors: Logan Deirdre E. , Breazeal Cynthia , Goodwin Matthew S. , Jeong Sooyeon , O’Connell Brianna , Smith-Freedman Duncan , Heathers James , Weinstock Peter 
Published: June 2019

BACKGROUND AND OBJECTIVES:
Social robots (SRs) are increasingly present in medical and educational contexts, but their use in inpatient pediatric settings has not been demonstrated in studies. In this study, we aimed to (1) describe the introduction of SR technology into the pediatric inpatient setting through an innovative partnership among a pediatric teaching hospital, robotics development, and computational behavioral science laboratories and (2) present feasibility and acceptability data.

METHODS:
Fifty-four children ages 3 to 10 years were randomly exposed to 1 of 3 interventions: (1) interactive SR teddy bear; (2) tablet-based avatar version of the bear; or (3) plush teddy bear with human presence. We monitored intervention enrollment and completion patterns, obtained qualitative feedback on acceptability of SR use from child life–specialist stakeholders, and assessed children’s positive and negative affect, anxiety, and pain intensity pre- and postintervention.

RESULTS:
The intervention was well received and appeared feasible, with 93% of those enrolled completing the study (with 80% complete parent data). Children exposed to the SR reported more positive affect relative to those who received a plush animal. SR interactions were characterized by greater levels of joyfulness and agreeableness than comparison interventions. Child life specialist stakeholders reported numerous potential benefits of SR technology in the pediatric setting.

CONCLUSIONS:
The SR appears to be an engaging tool that may provide new ways to address the emotional needs of hospitalized children, potentially increasing access to emotionally targeted interventions. Rigorous development and validation of SR technology in pediatrics could ultimately lead to scalable and cost-effective tools to improve the patient care experience.
Acciones biológicas y fisiológicas del GLP-1
Authors: Camacho Vargas Shirley , González Castellón Carolina Abigail , Solís Vargas Montserrat , Fernández Ramírez Aileen , Alvarado Fernández Victor 
Published: June 2019

El péptido similar al glucagón tipo 1 (GLP-1) derivado del proglucagón, consta de 42 aminoácidos y es liberado en respuesta a estímulos hormonales, neuronales y nutricionales. Este es producido por las células enteroendocrinas tipo L del tracto intestinal, células α del páncreas y en neuronas del núcleo del tracto solitario. El GLP-1 actúa sobre los receptores de GLP-1 y es degradado rápidamente por la dipeptidil peptidasa 4. El GLP-1, es una de las incretinas que promueve la transcripción de la insulina y su secreción; adicionalmente se ha demostrado que es un factor trófico de las células β pancreáticas. Este péptido también presenta efectos en el sistema nervioso central, donde actúa como agente neuroprotector y anorexígeno, gastrointestinales, cardiovasculares, renales, óseos y a nivel metabólico. Los cambios metabólicos observados posterior a una cirugía bariátrica, se consideran mediados por la acción del GLP-1. En la actualidad, se han desarrollado múltiples agonistas del receptor de GLP-1, los cuales están siendo utilizados principalmente como tratamiento hipoglicemiante en los pacientes que padecen diabetes mellitus tipo 2.
Koncepcja narzędzia informatycznego „elektroniczny nakaz doprowadzenia” przeznaczonego dla organów wymiaru sprawiedliwości
Authors: Trąbka Jan 
Published: June 2019

The article presents the concept of good practice in IT and the implementation of EDI technology in the Polish judicial system. The concept of good practice was described in the implementation of the pilot project of good management of the subordinate units of the Polish Ministry of Justice as a part of the project “Education in the time and cost management of judicial proceedings – case management”. The project was partially funded by the European Social Fund within the framework of Human Capital. The aim of the good practice “Digital writ of habeas corpus” (abbreviated to d-writ) is to introduce tools for electronic data interchange (EDI). These tools facilitate orders bringing prisoners and/or witnesses to courts by the police (replace paper communication with EDI communication channel embedded in IS of interested parties). It uses XML-based EDI protocol and encrypted data channel. The digital writ of habeas corpus saves both the courts an police money, and reduces the duration and complexity of the process. The article presents the assumptions of good d-writ practice, the technology involved and the stages of the project’s implementation.
Infrastructure scour management: a case study for A68 Galadean Bridge, UK
Authors: Koursari Eftychia , Wallace Stuart 
Published: June 2019

Scour can be responsible for compromising the stability of bridges and, if not identified early and adequately addressed, can lead to the catastrophic failure of a structure. BD 97/12 of the Design Manual for Roads and Bridges is used for the assessment of bridges and other structures over or adjacent to a watercourse and allows application of risk ratings based on variable circumstances and therefore a logical approach to investment in scour-related issues. Structures considered to be particularly at risk of scour are being subject to reactive safety inspections following events likely to increase water levels. This study describes efforts to use engineering measures for increased protection against scouring at A68 240 Galadean Bridge, UK. In this case, sediment transport has formed an island upstream of the structure, introducing a bend into what used to be a straight section of Leader Water, resulting in the river being redirected towards the western riverbank. As a result, the northwestern embankment of the A68, the outer side of the bend, has been significantly eroded. This case study emphasises the importance of changes in the morphology of a watercourse to be identified at early stages.
Refurbishing the historic Old Tweed Bridge, Scotland – the challenges and innovations
Authors: Grubb Andrew , O'Connor Kieran , McDonald Hazel 
Published: June 2019

The historic Old Tweed Bridge is a three-span listed masonry arch crossing the River Tweed. Structural integrity concerns resulted in the bridge being temporarily closed to the public and propped. This paper discusses the challenges associated with the construction works necessary to refurbish the bridge permanently. The works involved installing a temporary propping and encapsulation structure, excavating the bridge infill, taking down and rebuilding the walls, casting a concrete saddle above the arches, waterproofing and resurfacing. Other innovative works involved closing the gap between the voussoirs and arch barrel using a bespoke arch pulling system and repairing voussoir stones in situ with a lime-based material. There were significant environmental challenges on the project as the bridge is located in an ecologically sensitive area. The River Tweed is one of the UK's great salmon rivers, which restricted working in the river and required strict pollution controls. Alternative roosts for bats were provided and netting was required around the bridge as part of an advanced works contract to mitigate the risk of birds nesting in the bridge.
Family’s experience in Caring of Cancer Patient undergoing Oral Chemotherapy : A Study Phenomenology
Authors: Huda Nurul , Erwin Erwin , Febriyanti Eka 
Published: June 2019

ABSTRACTThe use of Oral Chemotherapy is increasing nowadays. Family who directly involve in caring the patient should be aware of the side effect and how to handle this agent safely. Phenomenology approach of qualitative study was conducted to get illustration regarding family experience in managing care of patient receiving oral chemotherapy. Data was collected by semi structured interviewed. Study gathered from 10 participants who meet criteria. The current study showed that three temathic item related to how they manage care to their family’s member. Those are 1) Lack of knolwedge about oral chemotherapy, 2) Confusing in handling safe oral chemotherapy and 3) lack of ability in caring patients when side effect appeared and following adherence. These three things are considered lacked by the patients. Therefore, health care professional especially nurses are expected to give more education and attention about administering oral chemotherapy agents, safe handling, adherence and managing side effects both of in clinical and home setting. Multi-component interventions that include education, equipment, and technology can improve compliance with oral chemotherapy and will help families to secure and provide the appropriate affection to them.ABSTRAKPenggunaan kemoterapi oral semakin meningkat saat ini. Keluarga yang secara langsung terlibat dalam merawat pasien harus menyadari efek samping dan cara menangani terapi ini dengan aman. Penelitian kualitatif dengan pendekatan fenomenologi dilakukan untuk mendapatkan gambaran mengenai pengalaman keluarga dalam mengelola perawatan pasien yang menerima kemoterapi oral. Data dikumpulkan secara semi terstruktur melalui wawancara. Penelitian ini terdiri dari 10 partisipan keluarga yang memenuhi kriteria inklusi. Hasil penelitian menunjukkan terdapat tiga tema terkait bagaimana keluarga merawat pasien dengan oral chemotherapy di rumah. Ketiga tema tersebut adalah 1) kurangnya pengetahuan keluarga tentang oral kemoterapi, 2) kebingungan keluarga dalam penanganan keamanan oral chemotherapy dan 3) ketidakmampuan keluarga dalam menangani efek samping dan menjaga kepatuhan. Ketiga hal ini dianggap masih belum bisa dilakukan oleh keluarga dan membutuhkan bimbingan serta informasi dari petugas kesehatan. Oleh karena itu, petugas kesehatan professional terutama perawat diharapkan dapat memberikan edukasi dan perhatian yang lebih kepada keluarga tentang bagaimana pemberian kemoterapi oral yang baik, penanganan yang aman serta peningkatan kepatuhan dalam menjalani perawatan. Memberikan intervensi multikomponen yang mencakup pendidikan, peralatan pendukung, dan teknologi dipercayai dapat meningkatkan kemampuan dalam perawatan dan kepatuhan dalam menjalani kemoterapi oral, sehingga dapat membantu keluarga untuk memberikan rasa aman dan kasih sayang yang kepada pasien.
ОПТИМИЗАЦИЯ МАРШРУТОВ ПРОКЛАДКИ МАГИСТРАЛЬНОГО ТРУБОПРОВОДА ДЛЯ ТРАНСПОРТИРОВКИ ГЕОРЕСУРСОВ
Authors: Токтошов Гулжигит Ысакович , Юргенсон Анастасия Николаевна , Мигов Денис Александрович 
Published: June 2019

Актуальность исследования обусловлена необходимостью транспортировки добытого георесурса от месторождений до их переработки, с целью дальнейшего распределения между потребителями ресурсов различного назначения. В связи с этим актуальным является задача выбора маршрута прокладки магистрального трубопровода, осуществляющего транспортировку георесурсов от места добычи до мест их переработки. При этом должна быть обеспечена минимальность капитальных вложений и эксплуатационных затрат, а также надёжность функционирования магистрального трубопровода в условиях непредвиденных природно-техногенных воздействий. Цель: предложить новый метод для прокладки магистрального трубопровода, учитывающий совместимость или несовместимость различных типов трубопроводного транспорта в одном техническом коридоре, а также надежность их функционирования. Объекты: магистральный трубопровод, прокладываемый на заданной территории. Методы: методы теории графов и теории гиперсетей; методы эволюционного синтеза; компьютерное моделирование процесса транспортировки георесурсов; дискретизация области размещения магистрального трубопровода. Результаты. Предложен новый математический аппарат, основанный на модели теории гиперсетей, учитывающий иерархичность структуры проектируемого магистрального трубопровода. На основе гиперсетевого подхода получен новый метод прокладки магистрального трубопровода, учитывающий несовместимость различных типов ресурсов для прокладки в одном техническом коридоре. Разработан двухэтапный метод построения магистрального трубопровода, обеспечивающий минимальность капитальных вложений и эксплуатационных затрат. Кроме того, разработан модифицированный муравьиный алгоритм, обеспечивающий получение не только дешевого решения, но и достаточно надёжного по отношению к заданному порогу, при условии, что сбои происходят в первичной (физической) сети. В качестве показателя надёжности мы рассматриваем минимум среди всех парных вероятностей связности между каждым перерабатывающим пунктом и соответствующим источником. Полученные в ходе исследования численные эксперименты показывают применимость предложенных нами методов.