bluuebunny/crossref_metadata_2025_split huggingface dataset:
Laju Dekomposisi Serasah Daun di Ekosistem Bakau Pulau Kelong, Kabupaten Bintan
Authors: Dharmawan I Wayan Eka , Zamani Neviaty P. , Madduppa Hawis H. 
Published: October 2019

<strong>Decomposition Rate of Leaf Litter in The Mangrove Ecosystem of Kelong Island, Bintan Regency.</strong> The mangrove forests in the southeastern part of Kelong Island have abundant carbon reserves that indicate high primary productivity areas. Decomposition of leaf litter, as a part of regional productivity, produces simple essential nutrients utilized to sustain the growth of mangroves. The purpose of this study was to determine the decomposition rate of leaf litter in each zone of the study, the Landward (L), Middlezone (M), and Seaward (S) which is distinguished by the abundance of plant species and in situ environmental parameters. The experiment was conducted in March–May 2015 in the mangrove areas of Island Kelong, Bintan regency. The decomposition process was observed at six time intervals, i.e. 2, 4, 7, 14, 28, and 42 days using net bag containing 10 g of wet leaves placed on the substrate surface. The results showed that L was a zone with highest percentage of decomposition (56.34 ± 20.58%) compared to the M and S, respectively for 51.59 ± 15.46% and 51.09 ± 8.70%. The highest rate of litter decomposition in zone L was 1.40 ± 0.82 g·m-2·day-1 that was significantly different from the zones M and S, respectively of 0.83 ± 0.89 g·m-2·day-1 and 0.78 ± 0.70 g·m-2·day-1. Analysis of the coefficient of decomposition rate (k) indicated that the rate of decomposition in this region was high (k &gt; 0.01). The decomposition rate has a significant correlation with the abundance of mangrove species, the salinity value of the water, and soil temperature.
Kajian Metode Klasifikasi Citra Landsat-8 untuk Pemetaan Habitat Bentik di Kepulauan Padaido, Papua
Authors: Hafizt Muhammad , Iswari Marindah Yulia , Prayudha Bayu 
Published: October 2019

<strong>Assessment of Landsat-8 Classification Method for Benthic Habitat Mapping in Padaido Islands, Papua.</strong> Indonesia is the biggest archipelagic country in the world with an area of coral reefs of 39,583 km.This area has to be managed effectively and efficiently utilizing satellite remote sensing technique capable of mapping of benthic habitat coverage, such as coral reefs, seagrasses, macroalgae, and bare substrates. The technique is supported by the availability of Landsat-8 OLI satellite images that have been recording the regions of Indonesia continuously every 16 days. This research was carried out in June 2015 in parts of Padaido Islands, Papua. This area was selected due to high coral reef damages. This study utilized Landsat-8 OLI to compare two classification methods, namely pixel based and object based methods using ‘maximum 2 likelihood’ (ML) and ‘example based feature extraction’ classifications, respectively, after water column correction (Lyzenga method). The results showed that both methods produced benthic habitat maps with 7 class covers. The pixel-based classification resulted in a better overall accuracy (47.57%) in the mapping of benthic habitats than object-based classification approach (36.17%). Thus, the ML classification is applicable for benthic habitat mapping in Padaido Islands. However, the consistency of this method must be analyzed in many diffrent locations of Indonesian waters.
Distribusi Sedimen Permukaan Dasar Laut Perairan Sumba, Nusa Tenggara Timur
Authors: Putra Purna Sulastya , Nugroho Septriono Hari 
Published: October 2019

<strong>Subsurface sediment distribution in the Sumba Waters, East Nusa Tenggara.</strong> Marine geological survey of the Ekspedisi Widya Nusantara 2016 was conducted in the Sumba Waters on 4 to 26 August 2016 using Baruna Jaya VIII research vessel. The aim of this survey was to reveal the type and characteristics of the subsurface sediments of the Sumba Waters. A total of 13 samples were taken from the different depth in the subsurface bottom of the sea using grabbing methode with box corer. Grain size analysis were conducted using Mastersizer 2000 to understand the characteristics and the sediment type distribution. In general, the type of the subsurface sediment in the Sumba Waters is ranging from medium to very coarse sandy silt. Distribution of the subsurface sediments is correlated to depths. Grain size of the sediments in the Sumba Strait is coarser than in the western and southern of Sumba Island that directly connected to the Indian Ocean. Distribution of the subsurface sediment showing that the sediment, which are distributed further away from the coast is poorly sorted. The deposition of the subsurface-sea sediment is interpreted to represent a calm, and slow sedimentation mechanism under uniform suspension process.
Cadangan Karbon di Area Padang Lamun Pesisir Pulau Bintan, Kepulauan Riau
Authors: Indriani . , Wahyudi Aan J. , Yona Defri 
Published: October 2019

<strong>Carbon Stock in Seagrass Meadows of Bintan Island, Riau Archipelago.</strong> Carbon dioxide (CO<sub>2</sub>) is the main component of greenhouse gas that contributes to global warming. About 40 Tt CO<sub>2 </sub>was accumulated in the ocean plays an important role in the oceans’s carbon cycle. The ocean can absorb CO<sub>2 </sub>through photosynthesis by the planktonic community or coastal vegetations (i.e. seagrass and mangrove) to reduce atmospheric CO<sub>2</sub>. As a study case, we assessed Bintan Island that has the extensive area of seagrass meadows. The potential of seagrass meadows, especially in the absorption of CO<sub>2 </sub>can be estimated by determining the carbon stock. The dominant species of seagrass in Bintan Island are <em>Enhalus acoroides</em> and <em>Thalassia hemprichii</em>. The objectives of this study are carbon stock assessment of the sediment and seagrass habitus (i.e above substrate (AS) consist of leave blades and fronds and Below Substrate (BS) consist of roots and rhizomes). We compare carbon stock between AS and BS, as well as between two species. The result of the research show that carbon estimation value in Pengudang Station (PS) (68.398,47 g C/m<sup>2</sup>) is higher than Teluk Bakau Station (57.763,47 g C/m<sup>2</sup>). The carbon estimation value of <em>E. acoroides</em> is higher that others either in TBS of PS. The carbon stock in BS is higher than AS. While the estimated carbon stock in the sediment in PS was higher than in TBS.
Theu+gen construction in Modern Standard Russian
Authors: Luraghi Silvia , Naccarato Chiara , Pinelli Erica 
Published: October 2019

AbstractIn Modern Standard Russian (MSR), the prefix/preposition pairu-/uis peculiar with respect to other similar pairs, due to the meaning mismatch between the two. While the prefixu- has an ablative meaning, as shown when it is prefixed to motion verbs, the prepositional phraseu+gen occurs in locative constructions, and other related constructions, such as predicative possession that is expressed via the cross-linguistically common Locative Schema. Etymological considerations show that the meaning preserved by the prefix is older. The only type of occurrence which, according to the literature, preserves the ablative meaning for theu+gen construction is found with verbs of requesting, removing, and buying. Notably, however, in other Slavic languages putative ablative contexts are limited to verbs of requesting. Data from MSR, Old Church Slavic, Polish and Czech lead to the conclusion that the extension of theu+gen construction to verbs of removing in MSR is based on its use for the encoding of predicative possession. Extension to verbs of buying is better explained through the locative meaning of the construction. As a result of different developments, theu+gen construction has become part of the argument structure of a group of verbs including verbs of asking and requesting, verbs of removing, and verbs of buying, which are characterized by the common feature of taking human non-recipient third arguments. We argue that the different usages of theu+gen construction in MSR constitute an instance of constructionalization based on the merger of originally different constructions. We further argue that accounting for this development in constructional terms offers better insights in the relation among the various different usages ofu+gen than simply focusing on the meaning of the preposition and its polysemy pattern.
Large placental chorioangioma: a potential effective in-utero treatment modality for radio frequency ablation
Authors: Yulia Angela , Chelemen Oana , Bhutani Ruchi , Hutchinson Ciaran , Levine Samantha , Kamel Dia , Wimalasundera Ruwan 
Published: October 2019

Abstract

Background
Placenta chorioangiomas are common benign placental tumours. While microscopic chorioangiomas are frequent, macroscopic chorioangiomas of more than 5 cm are rare and often associated with fetal complications such as high output cardiac failure, fetal anaemia and stillbirth. Close monitoring and in-utero treatment are sometimes necessary to prevent adverse pregnancy outcome.

Case presentation
We present two cases of large placenta chorioangiomas with one case requiring surgical therapy with radiofrequency ablation (RFA) of tumour vessels, which resulted in a successful outcome of a live birth at term.

Conclusion
We conclude that RFA is an effective alternative treatment modality to fetoscopic laser therapy in utero for cases at risk of fetal cardiac failure and intrauterine demise in the presence of large chorioangiomas.
Converting GTP hydrolysis into motion: versatile translational elongation factor G
Authors: Rodnina Marina V. , Peske Frank , Peng Bee-Zen , Belardinelli Riccardo , Wintermeyer Wolfgang 
Published: October 2019

Abstract
Elongation factor G (EF-G) is a translational GTPase that acts at several stages of protein synthesis. Its canonical function is to catalyze tRNA movement during translation elongation, but it also acts at the last step of translation to promote ribosome recycling. Moreover, EF-G has additional functions, such as helping the ribosome to maintain the mRNA reading frame or to slide over non-coding stretches of the mRNA. EF-G has an unconventional GTPase cycle that couples the energy of GTP hydrolysis to movement. EF-G facilitates movement in the GDP-Pi form. To convert the energy of hydrolysis to movement, it requires various ligands in the A site, such as a tRNA in translocation, an mRNA secondary structure element in ribosome sliding, or ribosome recycling factor in post-termination complex disassembly. The ligand defines the direction and timing of EF-G-facilitated motion. In this review, we summarize recent advances in understanding the mechanism of EF-G action as a remarkable force-generating GTPase.
The Ras switch in structural and historical perspective
Authors: Gasper Raphael , Wittinghofer Fred 
Published: October 2019

Abstract
Since its discovery as an oncogene more than 40 years ago, Ras has been and still is in the focus of many academic and pharmaceutical labs around the world. A huge amount of work has accumulated on its biology. However, many questions about the role of the different Ras isoforms in health and disease still exist and a full understanding will require more intensive work in the future. Here we try to survey some of the structural findings in a historical perspective and how it has influenced our understanding of structure-function and mechanistic relationships of Ras and its interactions. The structures show that Ras is a stable molecular machine that uses the dynamics of its switch regions for the interaction with all regulators and effectors. This conformational flexibility has been used to create small molecule drug candidates against this important oncoprotein.
Targeted Forward Genetics: Population-Scale Analyses of Allele Replacements Spanning Thousands of Base Pairs in Fission Yeast
Authors: Storey Aaron J , Wang Hsin-Ping , Protacio Reine U , Davidson Mari K , Wahls Wayne P 
Published: October 2019

AbstractPrecise allele replacement (genome editing), without unwanted changes to the genome, provides a powerful tool to define the functions of DNA elements and encoded factors in their normal biological context. While CRISPR is now used extensively for gene targeting, its utility for precise allele replacement at population scale is limited because: (A) there is a strict requirement for a correctly positioned PAM motif to introduce recombinogenic dsDNA breaks (DSBs); (B) efficient replacements only occur very close to the DSBs; and (C) indels and off-target changes are frequently generated. Here we show, using a saturated mutation library with about 15,000 alleles of the ade6 gene of Schizosaccharomyces pombe, that pop-in, pop-out allele replacement circumvents these problems. Two rounds of selection ensure that clones arise by homologous recombination with the target locus. Moreover, the exceptionally high efficiency allows one to carry out the process in bulk, then screen individual clones for phenotypes and genotypes. Alleles were introduced successfully throughout the region targeted, up to 1,956 base pairs from the DSB. About 11% of mutant alleles were hypomorphic, demonstrating utility for analyses of essential genes and genetic elements. This process of “targeted forward genetics” can be used to analyze comprehensively, across thousands of base pairs within a specific target region, a variety of allelic changes, such as scanning amino acid substitutions, deletions, and epitope tags. The overall approach and optimized workflow are extensible to other organisms that support gene targeting.
Distinct Functions in Regulation of Meiotic Crossovers for DNA Damage Response Clamp Loader Rad24(Rad17) and Mec1(ATR) Kinase
Authors: Shinohara Miki , Bishop Douglas K , Shinohara Akira 
Published: October 2019

Abstract
The number and distribution of meiotic crossovers (COs) are highly regulated, reflecting the requirement for COs during the first round of meiotic chromosome segregation. CO control includes CO assurance and CO interference, which promote at least one CO per chromosome bivalent and evenly-spaced COs, respectively. Previous studies revealed a role for the DNA damage response (DDR) clamp and the clamp loader in CO formation by promoting interfering COs and interhomolog recombination, and also by suppressing ectopic recombination. In this study, we use classical tetrad analysis of Saccharomyces cerevisiae to show that a mutant defective in RAD24, which encodes the DDR clamp loader (RAD17 in other organisms), displayed reduced CO frequencies on two shorter chromosomes (III and V), but not on a long chromosome (chromosome VII). The residual COs in the rad24 mutant do not show interference. In contrast to rad24, mutants defective in the ATR kinase homolog Mec1, including a mec1 null and a mec1 kinase-dead mutant, show slight or few defects in CO frequency. On the other hand, mec1 COs show defects in interference, similar to the rad24 mutant. Our results support a model in which the DDR clamp and clamp-loader proteins promote interfering COs by recruiting pro-CO Zip, Mer, and Msh proteins to recombination sites, while the Mec1 kinase regulates CO distribution by a distinct mechanism. Moreover, CO formation and its control are implemented in a chromosome-specific manner, which may reflect a role for chromosome size in regulation.
Congenital Heart Disease and Autism: A Case-Control Study
Authors: Sigmon Eric R. , Kelleman Michael , Susi Apryl , Nylund Cade M. , Oster Matthew E. 
Published: October 2019

OBJECTIVES:
There has long been an association between congenital heart disease (CHD) and general neurodevelopmental delays. However, the association between CHD and autism spectrum disorders (AuSDs) is less well understood. Using administrative data, we sought to determine the association between CHD and AuSD and identify specific CHD lesions with higher odds of developing AuSD.

METHODS:
We performed a 1:3 case-control study of children enrolled in the US Military Health System from 2001 to 2013. Children with International Classification of Disease, Ninth Revision, Clinical Modification codes for AuSD were identified as cases and matched with controls on the basis of date of birth, sex, and enrollment time frame. Each child’s records were reviewed for CHD lesions and associated procedures. Conditional logistic regression determined odds ratios (ORs) and 95% confidence intervals (CIs) for comparative associations.

RESULTS:
There were 8760 cases with AuSD and 26 280 controls included in the study. After adjustment for genetic syndrome, maternal age, gestational diabetes, short gestation, newborn epilepsy, birth asphyxia, and low birth weight, there were increased odds of AuSD in patients with CHD (OR 1.32; 95% CI 1.10–1.59). Specific lesions with significant OR included atrial septal defects (n = 82; OR 1.72; 95% CI 1.07–2.74) and ventricular septal defects (n = 193; OR 1.65; 95% CI 1.21–2.25).

CONCLUSIONS:
Children with CHD have increased odds of developing AuSD. Specific lesions associated with increased risk include atrial septal defects and ventricular septal defects. These findings will be useful for counseling parents of children with CHD.
Evaluación de la habitabilidad en barrios. Uso de técnicas alternativas
Authors: León Rodríguez Adriana Del Pilar , Alfonso Ávila Julieth Viviana , Díaz Márquez Sonia Esperanza , Quevedo Reyes Jorge Enrique 
Published: October 2019

En la planificación de una ciudad se debe garantizar el diseño de barrios habitables, que cuenten con una jerarquización vial ordenada, zonas verdes suficientes y un espacio público adecuado, permitiendo la integración con las demás actividades de la ciudad. Sin embargo, cuando el barrio ya está construido, la acción del planificador se dirige a determinar su nivel de habitabilidad para establecer las necesidades de intervención. Así, el propósito de este artículo es evaluar la habitabilidad de barrios, considerando indicadores de movilidad y urbanismo, por medio del uso de técnicas no tradicionales en la ingeniería de transporte como la cartografía social, la observación aérea y una aplicación móvil (Mobydick). Para ello, se tomó como caso de estudio el barrio Asís en Tunja (Colombia). Como resultado, se evidenció que el uso simultáneo de técnicas interdisciplinarias complementa la evaluación de habitabilidad en una unidad funcional como el barrio, desde el punto de vista de la movilidad.
Formas de mobilidade, visibilidade e poder em Medellín: Metrocable e Parques- Biblioteca
Authors: Capillé Cauê , Reiss Camille 
Published: October 2019

As renovações urbanas de Medellín tornaram-se modelo para a América Latina. O projeto integrado de transporte complementar ao metrô (em especial, os teleféricos) e de novos equipamentos culturais (em especial, bibliotecas públicas) abriu espaço para permitiu a atuação do Estado na melhoria da qualidade de vida nas áreas informais da cidade. No entanto, ao centralizar a gestão da mobilidade por intermédio de grandes infraestruturas de escala urbana, observa-se que os sistemas auto-organizacionais existentes são gradativamente substituídos ou sobrepostos pelo projeto estatal de renovação. É, portanto, importante compreender que esta nova “presença” (espacial e institucional) do Estado implica na modificação de sistemas de poder locais, para além da possibilidade de mobilidade urbana e acesso a serviços públicos. Este artigo analisa as culturas espaciais e territoriais dos Metrocables e dos Parques-Biblioteca. Discute, por fim, como essas culturas espaciais de acesso e domínio visual ao/do território urbano implicam em diferentes formas de poder na cidade.
Lope de Vega. <em>Las bodas entre el Alma y el Amor Divino. El hijo pródigo</em>. Edición de J. Enrique Duarte. Kassel: Reichenberger, 2017, 282 páginas
Authors: Chen Sham Jorge 
Published: October 2019

Lope de Vega. Las bodas entre el Alma y el Amor Divino. El hijo pródigo. Edición de J. Enrique Duarte. Kassel: Reichenberger, 2017, 282 páginas
Efeito do treinamento com flauta doce na força muscular respiratória de idosas: estudo piloto
Authors: Viana Dayane Aparecida , Vicentini de Oliveira Daniel , Sousa Perogari Maycon , Alves Silva Lilane Maria , Ruas Gualberto , Patrizzi Lislei Jorge , Ribeiro Luiz Gonçalves Jurema 
Published: October 2019

Objetivo: O objetivo deste estudo foi mensurar a força muscular respiratória de idosas com treinamento com flauta doce. Métodos: Estudo quasi-experimental realizado com cinco idosas. As idosas foram submetidas a oito semanas de treinamento presenciais de 90 minutos com flauta doce referente a música “Noite Feliz”. A mensuração da força muscular respiratória foi realizada antes e após o período de treinamento, por meio de um manovacuômetro e a função respiratória por meio da espirometria. Utilizou-se a estatística descritiva e inferencial, considerando p<0,05. Resultados: A prova de função pulmonar não apresentou nenhuma alteração, com média de CVF, VEF1, VEF1/CVF (80±5, 82±5 e 89±6 %, respectivamente). No entanto, a PImáx e a PEmáx apresentaram aumentos significantemente após o treinamento (54±20 vs 98±8 cmH2O, p<0,04 e 40±14 vs 68±17 cmH2O, p<0,03 respectivamente). Conclusão: Houve aumento da força muscular respiratório de idosas submetidas a um treinamento com flauta doce.
Endocrine-Related Adverse Events Related to Immune Checkpoint Inhibitors: Proposed Algorithms for Management
Authors: Del Rivero Jaydira , Cordes Lisa M. , Klubo-Gwiezdzinska Joanna , Madan Ravi A. , Nieman Lynnette K. , Gulley James L. 
Published: October 2019

Abstract

Immune checkpoint inhibitors have proven to be effective for various advanced neoplasia. Immune-related adverse events (irAEs) as a result of increased T cell activation are unique and potentially life-threating toxicities associated with the use of immune checkpoint inhibitors. Multiple endocrine irAEs, including primary hyperthyroidism and hypothyroidism, thyroiditis, primary adrenal insufficiency, type 1 diabetes mellitus, and hypophysitis, have been reported with the use of various immune checkpoint inhibitors. In some cases, these irAEs can lead to discontinuation of treatment. Here we propose for the general oncologist algorithms for managing endocrine irAEs to aid in the clinical care of patients receiving immunotherapy.

Key Points
There is a relative high risk of endocrine immune-related adverse events (irAEs) during therapy with checkpoint inhibitors, particularly when combination therapy is implemented. Patients treated with anti-CTLA-4 antibodies have an increased risk of hypophysitis, whereas patients treated with anti-PD-1/PD-L1 antibodies have a higher risk of primary thyroid dysfunction. Rarely, patients develop T1DM and central diabetes insipidus, and hypoparathyroidism is a rare occurrence. A growing clinical understanding of endocrine irAEs has led to effective treatment strategies with hormone replacement.