bluuebunny/crossref_metadata_2025_split huggingface dataset:
Usefulness of contrast-enhanced and TOF MR angiography for follow-up after low-profile stent-assisted coil embolization of intracranial aneurysms
Authors: Akkaya Selcuk , Akca Onur , Arat Anıl , Peker Ahmet , Balci Sinan 
Published: July 2018

Background Low-profile, self-expandable stents are used to treat wide-neck aneurysms located on the smaller distal intracranial arteries. This study aimed to assess the usefulness of time-of-flight (TOF) and contrast-enhanced (CE) magnetic resonance angiography (MRA) for follow-up after LEO Baby stent (LBS)-assisted coil embolization. Methods Twenty-four aneurysms treated with LBS-assisted coil embolization were evaluated. Researchers reviewed TOF MRA and CE MRA images in terms of occlusion and stent patency. Aneurysm occlusion was graded according to Raymond–Roy classification as follows: total occlusion (grade 1), residual neck (grade 2), and residual aneurysm (grade 3). Stent patency was scored as follows: occlusion (1), stenosis (2), and normal (3). Interobserver and intermodality agreement values were determined by weighted kappa (κ) statistics. Results Intermodality and interobserver values of TOF MRA and CE MRA with digital subtraction angiography (DSA) were perfect (κ = 1.00, p < 0.001) in terms of aneurysm occlusion. Rate of stent occlusion and stenosis in DSA, TOF, and MRA, respectively, were as follows: 0 and 12.5%, 16.6 and 70.8%, and 0 and 62.5%. Intermodality agreement values of TOF MRA and CE MRA with DSA were insignificant in terms of stent patency (κ = 0.065, p = 0.27; κ = 0.158, p = 0.15, respectively). Interobserver agreement was substantial in both TOF MRA (κ = 0.71, p < 0.001) and CE MRA (κ = 0.64, p = 0.001). Conclusions Both TOF and CE MRA techniques have strong concordance with DSA for the detection of aneurysm occlusion status. CE MRA can be used as a first-line noninvasive imaging modality due to its superiority to TOF MRA with respect to the visualization of in-stent signals.
Weekend Admission of Intracapsular Femoral Neck Fractures Not Associated With a Greater Rate of Mortality or Morbidity
Authors: Rezaie Wahid , Roukema Gert , Van de Meulebroucke Bart 
Published: July 2018

Introduction: For a number of emergency conditions, admission over the weekend has been associated with rising morbidity and mortality rates. However, different studies have provided conflicting results regarding the increased rates of mortality and morbidity for patients with intracapsular femoral fracture who were admitted over the weekend, compared to weekdays. This study investigated the effect of weekend admissions on the surgical outcomes of patients with intracapsular femoral neck fractures. Materials and Methods: We conducted a retrospective cohort study of all the patients who were admitted to our level-II trauma center with an intracapsular femoral neck fracture between January 2009 and June 2011. Admission was classified as at the weekend if it took place between 18:00 pm on Friday until midnight on Sunday or on bank holidays. We compared the mortality rates within 30 days and 6 months after surgery for weekday and weekend admissions. Secondary outcomes considered included length of hospital stay, postoperative complications, and reoperation rates. Statistical analysis was performed using logistic regression models, which were adjusted for patient and surgical characteristics. Results: In total, 315 patients met our inclusion criteria. The mean age of this group was 77.9 years (standard deviation ±13) and the female to male ratio was 5:2. The average follow-up period was 49 months. Under logistic regression analysis, weekend admission was not a significant independent risk factor for the 30-day mortality rate (odds ratio 1.85, 95% confidence interval, 0.74-4.62; P = .19). Seventy-seven patients admitted over the weekend were treated within 24 hours versus 125 patients for the weekday group (80.2% vs 57.9%; P = .005). There were no differences between the sample groups in relation to implant-related complications (24.9% vs 25.8%, respectively, P = .89) nor in relation to general complications (12% vs 18.6%, respectively, P = .06). The mean hospital stay of patients operated on during weekends or holidays was significantly shorter compared to patients operated on during weekdays (6.7 vs 8.5 days; P = .009). Conclusion: Patients with intracapsular femoral neck fractures who were admitted over the weekend at our trauma center did not have a higher risk of mortality or morbidity. Furthermore, temporary preoperative care provided over the weekend by an internal medical consultant can be safe and efficient even in the circumstances where there is a lack of dedicated geriatric support. The absence of an elective operating list at the weekend could be a potential factor in shortening waiting times for surgery for intracapsular femoral neck fracture at weekends and holidays.
The common VWF single nucleotide variants c.2365A>G and c.2385T>C modify VWF biosynthesis and clearance
Authors: Mufti Ahmad H. , Ogiwara Kenichi , Swystun Laura L. , Eikenboom Jeroen C. J. , Budde Ulrich , Hopman Wilma M. , Halldén Christer , Goudemand Jenny , Peake Ian R. , Goodeve Anne C. , Lillicrap David , Hampshire Daniel J. 
Published: July 2018

Key Points
VWF variants c.2365A>G and c.2385T>C independently influence VWF biosynthesis and clearance, increasing VWF plasma levels. Commonly inherited VWF variants can directly influence the protein and may contribute to hemostatic and thrombotic disease risk/severity.
Trispecific killer engager CD16xIL15xCD33 potently induces NK cell activation and cytotoxicity against neoplastic mast cells
Authors: Don Yun Hyun , Felices Martin , Vallera Daniel A. , Hinderlie Peter , Cooley Sarah , Arock Michel , Gotlib Jason , Ustun Celalettin , Miller Jeffrey S. 
Published: July 2018

Key Points
NK cell natural cytotoxicity and antibody-dependent cellular cytotoxicity of patients with systemic mastocytosis are normal. Trispecific killer engagers (161533 TriKE) target NK cells from normal donors and systemic mastocytosis patients to kill mast cells.
Prediction of chronic kidney disease after acute kidney injury in ICU patients: study protocol for the PREDICT multicenter prospective observational study
Authors: Geri Guillaume , Stengel Bénédicte , Jacquelinet Christian , Aegerter Philippe , Massy Ziad A. , Vieillard-Baron Antoine ,   the PREDICT investigators, Legriel Stéphane , Laurent Virginie , Teboul Jean-Louis , Tarazona Anatole Virginie , Mekontso-Dessap Armand , Mira Jean-Paul , Diehl Jean-Luc , Pirracchio Romain , Bigé Naike , Dupuis Claire , Gaudry Stéphane , Maizel Julien , Souweine Bertrand , Zafrani Lara , Mégarbane Bruno , Mebazaa Alexandre , Durbach Antoine , Audard Vincent , Thervet Eric , Boffa Jean-Jacques , Hanouna Guillaume , Titeca Dimitri , Philiponnet Carole , Glotz Denis 
Published: July 2018

Abstract
Background
Acute kidney injury (AKI) is frequent and associated with poor outcome in intensive care unit (ICU) patients. Besides the association with short- and long-term mortality, the increased risk of chronic kidney disease (CKD) has been recently highlighted in non-ICU patients. This study aims to describe the incidence and determinants of CKD after AKI and to develop a prediction score for CKD in ICU patients.

Methods
Prospective multicenter (n = 17) observational study included 1200 ICU patients who suffered from AKI (defined by an AKIN stage ≥ 1) during their ICU stay and were discharged alive from ICU. Preexisting end-stage renal disease (ESRD) and immunosuppressant treatments are the main exclusion criteria. Patients will be monitored by a nephrologist at day 90 and every year for 3 years. The main outcome is the occurrence of CKD defined by a creatinine-based estimated glomerular filtration rate (eGFR) lower than 60 mL/min/1.73 m2 or renal replacement therapy for ESRD in patients whose eGFR will be normalized (≥ 60 mL/min/1.73 m2) at day 90. Secondary outcomes include albuminuria changes, eGFR decline slope and ESRD risk in patients with preexisting CKD, cardiovascular and thromboembolic events and health-related quality of life.

Discussion
This is the first study prospectively investigating kidney function evolution in ICU patients who suffered from AKI. Albuminuria and eGFR monitoring will allow to identify ICU patients at risk of CKD who may benefit from close surveillance after recovering from AKI. Major patient and AKI-related determinants will be tested to develop a prediction score for CKD in this population.
Trial registration ClinicalTrials.gov, NCT03282409. Registered on September 14, 2017
Lipidomics: a promising cancer biomarker
Authors: Yan Furong , Zhao Hong , Zeng Yiming 
Published: July 2018

AbstractThe prevention, diagnosis and targeted therapies of cancer are important in cancer controlling and treatment. The present challenge about cancer biomarker still remains in identifying the special biomarkers for predicting cancer risk and assessing patient's response during anticancer treatment. Lipidomics, in simple definition is the quantification of all lipids in a confined biological entity. Lipids play roles in membrane structure, energy storage, and signal transduction as well as in human cancers. Previous researches indicated that lipids may serve as a promising biomarker in the early diagnoses and individualized treatment of cancer.
Nodal and Hedgehog synergize in gill slit formation during development of the cephalochordate Branchiostoma floridae
Authors: Ono Hiroki , Koop Demian , Holland Linda Z. 
Published: July 2018

ABSTRACT
The larval pharynx of the cephalochordate Branchiostoma (amphioxus) is asymmetrical. The mouth is on the left, and endostyle and gill slits are on the right. At the neurula, Nodal and Hedgehog (Hh) expression becomes restricted to the left. To dissect their respective roles in gill slit formation, we inhibited each pathway separately for 20 min at intervals during the neurula stage, before gill slits penetrate, and monitored the effects on morphology and expression of pharyngeal markers. The results pinpoint the short interval spanning the gastrula/neurula transition as the critical period for specification and positioning of future gill slits. Thus, reduced Nodal signaling shifts the gill slits ventrally, skews the pharyngeal domains of Hh, Pax1/9, Pax2/5/8, Six1/2 and IrxC towards the left, and reduces Hh and Tbx1/10 expression in endoderm and mesoderm, respectively. Nodal auto-regulates. Decreased Hh signaling does not affect gill slit positions or Hh or Nodal expression, but it does reduce the domain of Gli, the Hh target, in the pharyngeal endoderm. Thus, during the neurula stage, Nodal and Hh cooperate in gill slit development – Hh mediates gill slit formation and Nodal establishes their left-right position.
Janus-Type Dendritic Organoiridium(III) Complex Bearing Hole- and Electron-Transporting Moieties: Synthesis, Luminescence Properties, and OLED Applications
Authors: Okamura Naoki , Maeda Takeshi , Yagi Shigeyuki 
Published: July 2018

Abstract
A novel tris-cyclometalated iridium(III) complex bearing carbazole-based hole-transporting and triarylphosphine oxide-based electron-transporting dendrons was synthesized through a convergent synthetic route, and its facial and meridional isomers were isolated by conventional silica gel chromatography. The facial isomer exhibited sky-blue photoluminescence (PL) from the phosphorescent core even in the neat film state with a relatively high PL quantum yield (ΦPL) of 0.57 because the dendrons efficiently suppress aggregate formation between the cores. The meridional isomer was less emissive (ΦPL; 0.029 in deaerated dichloromethane) but photoisomerized to the facial isomer by UV light irradiation (365 nm) in spite of large steric hindrance between the bulky dendrons. A non-doped organic light-emitting diode (OLED) employing the facial isomer exhibited sky-blue electroluminescence with a higher maximum external quantum efficiency (EQEmax) of 1.6% than that of a comparable device employing a reference complex bearing only hole-transporting dendrons (EQEmax; 0.5%). As lipophilic and apolar tert-butyl groups are placed on the molecular surface, the present dendritic complex is soluble in cyclohexane and insoluble in ethanol. Utilizing this characteristic solubility, non-doped multilayer OLEDs consisting of a stack of hole-transporting layer/emitting layer (the dendritic complex)/electron-transporting layer were fabricated by solution processing. One of the multilayer devices exhibited an improved EQEmax of 5.2%.
A Limitação Territorial da Coisa Julgada como Óbice ao Acesso à Justiça
Authors: Borges Daniela Meca , Ferreira Olavo Augusto Vianna Alves 
Published: July 2018

As ações coletivas têm como pontos sensíveis a discussão acerca da legitimidade e da coisa julgada. O presente estudo tem por escopo a análise desta última, em que o debate se justifica porque a coisa julgada reflete as consequências do processo no mundo real. A coisa julgada nas demandas coletivas teve sua extensão ampliada para operar-se erga omnes ou ultra partes (redação original do art. 16 da Lei n. 7.347/1985 e art. 103 da Lei n. 8.078/1990), objetivando evitar a multiplicação de demandas com o mesmo pedido e causa de pedir e a existência de decisões conflitantes. Ocorre que a Lei n. 9.494/1997, até hoje em vigor, alterou o artigo 16 da Lei da Ação Civil Pública (Lei n. 7.347/1985) para limitar a coisa julgada à competência territorial do órgão prolator. A partir de então, surgiram grandes celeumas na doutrina e na jurisprudência pátria quanto à constitucionalidade, eficácia e aplicabilidade desta alteração, que ainda não foram definitivamente dirimidas. Diante desse cenário, são feitas considerações críticas, mediante emprego do método dedutivo, acerca da limitação da coisa julgada pela competência territorial do órgão prolator da decisão, que permitem concluir pela sua incompatibilidade com o microssistema processual coletivo e, também, que ela representa barreira ao acesso à justiça.
O Princípio da Concentração da Matrícula e a Fraude à Execução: um Diálogo entre a Lei n. 13.097/2015 e o CPC/2015
Authors: Didier Jr Fredie Souza , Braga Paula Sarno 
Published: July 2018

Trata-se de um ensaio que visa a analisar a constitucionalidade formal dos arts. 54-56 da Lei n. 13.097/2015, considerando que a lei decorre da conversão de medida provisória que trata de tema de Direito material (e não processual). Visa, ainda, a demonstrar a compatibilidade desses artigos, que disciplinam a ciência da fraude como pressuposto necessário para a configuração de fraude à execução no contexto dos negócios imobiliários, com o regramento posterior do CPC/2015, que alcança, também, os negócios mobiliários. As leis em comento não se contrapõem e acabam sendo complementares entre si na regência da matéria.
Healthcare choices in Mumbai slums: A cross-sectional study
Authors: Naydenova Elina , Raghu Arvind , Ernst Johanna , Sahariah Sirazul A. , Gandhi Meera , Murphy Georgina 
Published: July 2018

Background: Informal urban settlements, known as slums, are the home for a large proportion of the world population. Healthcare in these environments is extremely complex, driven by poverty, environmental challenges, and poor access to formal health infrastructures. This study investigated healthcare challenges faced and choices made by slum dwellers in Mumbai, India. Methods: Structured interviews with 549 slum dwellers from 13 slum areas in Mumbai, India, were conducted in order to obtain a population profile of health-related socio-economic and lifestyle factors, disease history and healthcare access. Statistical tools such as multinomial logistic regression were used to examine the association between such factors and health choices. Results: Private providers (or a mixture of public and private) were seen to be preferred by the study population for most health conditions (62% - 90% health consultations), apart from pregnancy (43% health consultations). Community-based services were also preferred to more remote options. Stark differences in healthcare access were observed between well-known conditions, such as minor injuries, pulmonary conditions, and pregnancy and emerging challenges, such as hypertension and diabetes. A number of socio-economic and lifestyle factors were found to be associated with health-related decisions, including choice of provider and expenditure. Conclusions: Better planning and coordination of health services, across public and private providers, is required to address mortality and morbidity in slum communities in India. This study provides insights into the complex landscape of diseases and health providers that slum dwellers navigate when accessing healthcare. Findings suggest that integrated services and public-private partnerships could help address demand for affordable community-based care and progress towards the target of universal health coverage.
The Implications of Durability, Resilience and Energy Efficiency on the Advancement of Water Management in Wall Assemblies
Authors: Weston Theresa A. 
Published: July 2018

Abstract
As building, energy, and green codes become more stringent, new building technologies and innovations are being incorporated into the building envelope. When incorporating new technologies into building assemblies, traditional construction practices need to be adapted. However, as these adaptations of construction practices take place, they still need to maintain adherence to basic principles of water management to prevent moisture accumulation in building assemblies. A critical component of water management is water-resistive barriers. Water-resistive barriers are used in light-frame wall assemblies behind the cladding to control the ingress of water, which penetrates the cladding, and keep it from penetrating further into the wall. Traditional water-resistive barriers were asphalt-impregnated papers and felts, which were applied in shingle fashion over the wall studs or sheathing. Plastic building wraps have to a large extent replaced the traditional building papers, comprising 75 % of the U.S. housing market. Recently, new materials being used as water-resistive barriers include panel materials and fluid-applied coatings. Assessing the durability of water-resistive barriers has been complicated by this range of material types. Because of the shingle-fashion installation, durability assessment of traditional materials and building wraps has focused on the material durability. The new materials require additional durability assessments relating to compatibility and durability of adhesion, most importantly at panel and substrate joints. This article describes the framework for evaluating water-resistive barrier durability.
Pressure responses following the insertion of pro-seal laryngeal mask airway in patients with controlled hypertension: A comparison with tracheal intubation
Authors: Vavadia Drashti , Shah Rupal 
Published: July 2018

Aims & Objectives: To compare:1) Hemodynamic responses during insertion of pro-seal laryngeal mask airway (PLMA) vs endo-tracheal tubation (ETT) in hypertensive patients under control. 2) The incidence of complications.
Methods: A total of 30 patients aged between 45-60 years of ASA grade II having history of essential hypertension under control, were on oral medication who were posted for abdominal surgeries under GA were randomly divided into two groups of 15 each (One group for PLMA insertion and other for ETT insertion). The two groups were compared for pressor responses following insertion of PLMA or ETT.
Results: After PLMA Insertion, mean pulse increased from 67±7 to 68±5 per minute, Systolic Blood Pressure (BP) increased from 123±1 to 127±5 per mmHg, Diastolic BP increased from 72±8 to 78±7 per mmHg and Mean Artery Pressure (MAP) increased from 89±11 to 94±8 mm Hg. After ETT insertion: Mean pulse increased from 68±2 to 80±8 per minute, Systolic BP increased from 124±1 to 152±8 per mmHg, Diastolic BP increased from 72±8 to 96±8 per mmHg and MAP increased from 89±10 to 115±4 mm Hg.
Conclusion: We concluded that Proseal LMA is safe. It is judged by: Stable hemodynamics, adequate oxygenation, and ventilation and less complications.
Tuberculosis: Diagnosed and Undiagnosed as a Cause of Death
Authors: Gandhi Shivangi , Shah Pinal 
Published: July 2018

Aims and Objectives: This study has been conducted to find out the frequency of tuberculosis, histopathological pattern analysis of tuberculosis along with associated non-neoplastic changes and there role in the cause of death.
Methodology: A retrospective cross-sectional study is done based on a Histomorphological evaluation of 23 cases diagnosed at Department of Pathology, tertiary care hospital of south Gujarat from January 2017 to December 2017. We received the gross specimen of the lungs, heart, liver, kidney, spleen, and brain for post-mortem examination in all autopsy cases. We did gross pathological and histopathological analysis of all the autopsy cases sent for histopathology over a period of one year.
Results: In the present study out of 656 autopsy cases, 23 cases (3.5 %) were of granulomatous inflammation. Mean age of diagnosis was found to be 38 years. Males (65.2%) were more affected than females. Tuberculosis was diagnosed in only 21.7 % of total 23 cases before death. Findings were found in the lung in all cases while spread to the liver, spleen, kidney, and brain was also observed. Zeihl Neelson stain showing the presence of Acid Fast Bacilli confirms the diagnosis of tuberculous inflammation in 91% of cases.
Conclusion: Tuberculosis is not an uncommon finding at autopsy. The lack of diagnosis pre mortem might be attributable to either the presence of social stigma in some parts of the world that dissuades people from seeking timely medical assistance, or non-typical presentations of tuberculosis cases. Indeed, even autopsies potentially have a role in helping improve community health services.
English proficiency level in Colombian undergraduate students of medical programs
Authors: Alonso Julio César , Díaz Diana Margarita , Estrada Daniela , Mueces Brigitte Vanesa 
Published: July 2018

Introducción. El gobierno propuso posicionar a Colombia como un destino turístico de salud y bienestar, siendo uno de los objetivos aumentar los niveles de competencia del inglés en los profesionales de la salud. Esto se relaciona con la meta, para 2014, del Ministerio de Educación Nacional (MEN) de que 20% de los graduados deberían clasificar en nivel intermedio o superior en inglés.Objetivos. Analizar el cumplimiento de la meta establecida por el MEN para los graduandos de los programas de medicina.Materiales y métodos. Aproximación descriptiva y estadística (pruebas de proporciones paramétricas y no paramétricas) que empleó datos de la prueba Saber Pro (2011-2015) para los programas de medicina de las instituciones de educación superior de carácter académico universitario.Resultados. El porcentaje global de estudiantes que cumplió la meta (28.6%) fue satisfactorio; sin embargo, solo 18 de 43 (37.2%) programas de medicina la cumplieron.Conclusiones. El nivel de inglés de los potenciales graduados de los programas de medicina está alineado con la meta del gobierno. No obstante, hay mucho por mejorar si se tiene en cuenta que cerca del 70% de los futuros graduados de los programas de medicina no alcanza un nivel intermedio o superior en esta competencia.