bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exploring the moral compass
Authors: Márquez Reiter Rosina , Orthaber Sara 
Published: January 2019

AbstractWith the advent of the internet and social media, car and vanpooling have become easily available alternatives to public transport in many parts of the world. This paper draws on publicly available data from a Facebook car and vanpooling group used by Slovenian cross-border commuters to make their journeys to and from Austria more economically sustainable. It examines public displays of moral indignation following allegations of malpractice by relatively new members whose whole purpose in joining the group was to earn a living from driving vans across borders. Vanpool users collaboratively denounce van service providers for transgressing some of the social responsibilities that ought to bind members of the group together and for their lack of accountability. The accusations which entail exaggerations, complaints, insults and threats, among other hostile verbal attacks, convey moral indignation and are similarly resisted and challenged by the drivers. They offer a window into conflicting behavioural expectations at a time of socioeconomic change and transition. The alleged lack of van providers’ accountability which, in turn, informs the van users’ displays of moral indignation is indicative of the moral relativism that emerges as a result of the relocalisation and, the nature of a contemporary global practice at a time when changes in social life are underway. The primacy of the economic return that car and vanpooling offers service providers and cross-commuters with is oriented to by the former as outstripping the social responsibilities typically related to the provision of the regulated services, and by the latter, as morally unjustifiable despite acknowledging its economic value.
La vida tiene muchas curvas [Life has many curves]
Authors: Link Holly , Arango Obed 
Published: January 2019

Abstract
In this article, a conceptual discussion grounded in our practice as educators and scholars we use a bilingual
poem, collaboratively written by young people from Latinx immigrant backgrounds, as an entry point to engage with existing
discussions among practitioners and scholars on connections between translanguaging and Freirean praxis, and more broadly, on
translanguaging and its potential for social transformation. Grounding our discussion in our work at a bilingual community
education non-profit organization that seeks to empower Latinx immigrants, we explore how we are developing translanguaging spaces
for immigrant students and families, spaces guided by a collective vision of social transformation, through what we call
translanguaging praxis. Through articulating this translanguaging praxis, we foreground the transformative
potential of translanguaging. We argue that translanguaging is not only a political act but that it can also be a critical,
rebellious and creative one through which educators, students and families can respond to dominant narratives on Latinx immigrants
in the US, co-constructing counter-stories through which they express who they are from their own perspectives and in dialogue
with each other.
To language differently
Authors: Robinson Elizabeth 
Published: January 2019

AbstractThis article explores the synergies between translanguaging and feminist poststructuralism to deepen understandings of how educators can teach for justice. I highlight how both theories challenge dominant structures and boundaries; how they privilege process over product; and how they both illuminate non-dominant voices and experiences. I explore how both translanguaging and feminist poststructuralism have helped me challenge foundational epistemologies, ontologies, and methodologies as a teacher educator in the field of teaching English. Throughout this article I examine what taking up these theories to challenge and question the status quo means for how we might better engage language as a tool for justice.
Soy sauce increased the oxidative stress tolerance of nematode via p38 MAPK pathway
Authors: Sugawara Takaya , Saraprug Danaporn , Sakamoto Kazuichi 
Published: January 2019

ABSTRACT
Soy sauce – a fermented food made from soybeans and wheat – is considered a healthy seasoning, but little scientific evidence is available to support this. In this study, physiological effects of soy sauce were analyzed using Caenorhabditis elegans. When soy sauce was fed to C. elegans together with Escherichia coli OP50, fat accumulation decreased, and resistance to oxidative stress by H2O2 was greatly increased in the nematodes. qRT-PCR revealed that mRNA expression of oxidative stress tolerance genes, including sod, ctl, and gpx, was markedly increased in soy sauce-fed nematodes. Worms ingesting soy sauce showed high mitochondrial membrane potential and reactive oxygen species (ROS) and low intracellular ROS, suggesting that soy sauce induced mitohormesis and decreased cytoplasmic ROS. Therefore, soy sauce ingestion affects the mitochondria and may alter the fat metabolism in C. elegans. Furthermore, the increase in oxidative stress tolerance is mediated through p38 MAPK pathway.
Labour challenges in Ethiopia’s textile and leather industries: no voice, no loyalty, no exit?
Authors: Hardy Vincent , Hauge Jostein 
Published: January 2019

Abstract
A state-led industrialization push inspired by the East Asian ‘developmental state’ model is at the centre of Ethiopia’s recent economic success. This model has historically proved potent for achieving rapid industrialization, but the business-state alliance at the heart of the model generally aimed to curb the power of labour. Focusing on textile and leather manufacturing in Ethiopia, this article addresses two questions: are workers capable of extracting gains from the process of industrialization, and have the actions of workers affected global value chain integration in the two industries? Our data show that opportunities for collective voice among workers are limited. However, workers have expressed their discontent by leaving employers when working conditions fail to meet their expectations. The resulting turnover has generated significant obstacles for local and foreign firms attempting to participate in global value chains. In response, the Ethiopian state and employers implemented a number of measures, including restrictions on emigration and more generous non-wage benefits. Recent research on global value chains and labour highlights how workers are able to influence work practices through individual action. The present article builds on these ideas, but shows that firms and governments have the ability to respond and limit this power.
Improved indel detection in DNA and RNA via realignment with ABRA2
Authors: Mose Lisle E , Perou Charles M , Parker Joel S 
Published: January 2019

Abstract

Motivation
Genomic variant detection from next-generation sequencing has become established as an extremely important component of research and clinical diagnoses in both cancer and Mendelian disorders. Insertions and deletions (indels) are a common source of variation and can frequently impact functionality, thus making their detection vitally important. While substantial effort has gone into detecting indels from DNA, there is still opportunity for improvement. Further, detection of indels from RNA-Seq data has largely been an afterthought and offers another critical area for variant detection.

Results
We present here ABRA2, a redesign of the original ABRA implementation that offers support for realignment of both RNA and DNA short reads. The process results in improved accuracy and scalability including support for human whole genomes. Results demonstrate substantial improvement in indel detection for a variety of data types, including those that were not previously supported by ABRA. Further, ABRA2 results in broad improvements to variant calling accuracy across a wide range of post-processing workflows including whole genomes, targeted exomes and transcriptome sequencing.

Availability and implementation
ABRA2 is implemented in a combination of Java and C/C++ and is freely available to all from: https://github.com/mozack/abra2.

Supplementary information
Supplementary data are available at Bioinformatics online.
Cbs overdosage is necessary and sufficient to induce cognitive phenotypes in mouse models of Down syndrome and interacts genetically with Dyrk1a
Authors: Marechal Damien , Brault Véronique , Leon Alice , Martin Dehren , Lopes Pereira Patricia , Loaëc Nadege , Birling Marie-Christine , Friocourt Gaelle , Blondel Marc , Herault Yann 
Published: January 2019

Abstract
Identifying dosage-sensitive genes is a key to understand the mechanisms underlying intellectual disability in Down syndrome (DS). The Dp(17Abcg1-Cbs)1Yah DS mouse model (Dp1Yah) shows cognitive phenotypes that need to be investigated to identify the main genetic driver. Here, we report that three copies of the cystathionine-beta-synthase gene (Cbs) in the Dp1Yah mice are necessary to observe a deficit in the novel object recognition (NOR) paradigm. Moreover, the overexpression of Cbs alone is sufficient to induce deficits in the NOR test. Accordingly, overexpressing human CBS specifically in Camk2a-expressing neurons leads to impaired objects discrimination. Altogether, this shows that Cbs overdosage is involved in DS learning and memory phenotypes. To go further, we identified compounds that interfere with the phenotypical consequence of CBS overdosage in yeast. Pharmacological intervention in Tg(CBS) mice with one selected compound restored memory in the NOR test. In addition, using a genetic approach, we demonstrated an epistatic interaction between Cbs and Dyrk1a, another human chromosome 21-located gene (which encodes the dual-specificity tyrosine phosphorylation-regulated kinase 1a) and an already known target for DS therapeutic intervention. Further analysis using proteomic approaches highlighted several molecular pathways, including synaptic transmission, cell projection morphogenesis and actin cytoskeleton, that are affected by DYRK1A and CBS overexpression. Overall, we demonstrated that CBS overdosage underpins the DS-related recognition memory deficit and that both CBS and DYRK1A interact to control accurate memory processes in DS. In addition, our study establishes CBS as an intervention point for treating intellectual deficiencies linked to DS.
Early extubation improves outcome following extracardiac total cavopulmonary connection
Authors: Ono Masamichi , Georgiev Stanimir , Burri Melchior , Mayr Benedikt , Cleuziou Julie , Strbad Martina , Balling Gunter , Hager Alfred , Hörer Jürgen , Lange Rüdiger 
Published: January 2019

Abstract

OBJECTIVES
The aim of this study was to investigate the impact of an early extubation strategy on the outcome following extracardiac total cavopulmonary connection.

METHODS
From 1999 through 2017, 458 patients underwent extracardiac total cavopulmonary connection; 257 (56%) patients were managed with an early extubation strategy adopted in 2009 (group A). Their outcome was compared with those of 201 (44%) patients treated before 2009 (group B). In group A, the outcome of unstable patients, defined as >75th percentile for volume administered and inotrope scores, was compared with those of stable patients.

RESULTS
Ventilation time (median: 4 h vs 16 h, P < 0.001), fluid volume administered during the first 24 h (mean: 110 ml/kg vs 164 ml/kg, P = 0.003), chest tube duration (median: 3 days vs 4 days, P = 0.028) and length of intensive care unit stay (median: 6 days vs 7 days, P = 0.001) were less in group A than in group B. The reintubation rate (7% vs 6%, P = 0.547) and early mortality (0.8% vs 1.5%, P = 0.465) were similar between groups. The 80 unstable group A patients received more inotropic support (P < 0.001) and fluid volume (P < 0.001) than stable patients, but the ventilation time (6 h vs 5 h, P = 0.220), the reintubation rate (10% vs 6%, P = 0.283) and the length of intensive care unit stay (7 days vs 6 days, P = 0.590) were similar. In unstable patients, mean arterial pressure before extubation was significantly lower than stable patients (P = 0.001). However, mean arterial pressure in unstable patients increased significantly (P < 0.001) soon after extubation, and became similar to the value in stable patients.

CONCLUSIONS
Early extubation following extracardiac total cavopulmonary connection improves postoperative haemodynamics and recovery regardless of the initial haemodynamic status.
Rat Hepatitis E Virus Linked to Severe Acute Hepatitis in an Immunocompetent Patient
Authors: Andonov Anton , Robbins Mark , Borlang Jamie , Cao Jingxin , Hatchette Todd , Stueck Ashley , Deschambault Yvon , Murnaghan Kyle , Varga Jessy , Johnston Lynn 
Published: January 2019

Abstract
Hepatitis E virus (HEV) is a major public health concern in developing countries where the primary transmission is via contaminated water. Zoonotic HEV cases have been increasingly described in Europe, Japan, and the United States, with pigs representing the main animal reservoir of infection. We report an unusual acute hepatitis infection in a previously healthy man caused by a rat HEV with a considerably divergent genomic sequence compared with other rat HEV strains. It is possible that rat HEV is an underrecognized cause of hepatitis infection, and further studies are necessary to elucidate its potential risk and mode of transmission.
The Devil You Know: Self-Esteem and Switching Responses to Poor Service
Authors: Consiglio Irene , van Osselaer Stijn M J 
Published: January 2019

Abstract
We investigate a psychological factor regulating consumers’ switching in response to poor service quality: chronic global self-esteem. Whereas high-self-esteem consumers tend to switch to other providers in response to poor service quality, low-self-esteem consumers often do not. This happens because low-self-esteem consumers who experience poor service become risk-averse, and therefore reluctant to engage in new committed service relationships. Indeed, low-self-esteem consumers’ likelihood to switch to an alternative provider in response to poor service quality increases when this provider offers a less risky, low commitment (vs. more risky, high commitment) contract. Moreover, experimentally reducing low-self-esteem consumers’ risk aversion increases their likelihood to switch to alternative providers in response to poor service quality. Finally, low-self-esteem consumers’ risk aversion mediates their reluctance to switch in response to poor service. We rule out failure severity perceptions, power, autonomy, affect, and action orientation as alternative explanations. The implication of this research for public policy makers is that promoting competition (by offering consumers options and by reducing switching costs) may not be enough to protect the welfare of low-self-esteem consumers. We also suggest ways in which firms can untie vulnerable consumers from negative service relationships.
The Poetics of Narrativity: Understanding Trauma, Temporality, and Spatiality Forty Years after the Birmingham Pub Bombings
Authors: Nasar Saima , Schaffer Gavin 
Published: January 2019

Abstract
This article explores the social history of the Birmingham Pub Bombings (UK). In addition to individual losses and injuries, the bombings triggered widespread anti-Irish prejudice and violence, wrongful convictions and community tensions. The resultant disharmony within the city of Birmingham lasted for generations, while the voices of communities not directly involved in the events of November 21, 1974, have mostly remained silent. This article offers new lessons in the historical construction of trauma and how we make sense of traumatic events. Using original oral history interviews and witness seminars, it explores the layers of trauma that have been transmitted socially, politically, spatially, and intergenerationally. It begins by first focusing on the temporal and spatial dimensions of this local history, which reveal how the reconfiguring of temporalities can be used to locate an inner voice for British postwar, urban, social history. Then, it contextualizes individual and collective experiences of the Birmingham Pub Bombings in order to reveal the ways in which traumatic experiences are placed within a narrative form that orders and facilitates the integration of past trauma within the present. As such, we argue that the poetics of narrativity—or the narrative framing of how and when trauma memories are told, heard, and negotiated—has the potential to pull together a richer, more inclusive, community history.
Prospective multicenter surveillance of clinically isolated Aspergillus species revealed azole-resistant Aspergillus fumigatus isolates with TR34/L98H mutation in the Kyoto and Shiga regions of Japan
Authors: Tsuchido Yasuhiro , Tanaka Michio , Nakano Satoshi , Yamamoto Masaki , Matsumura Yasufumi , Nagao Miki 
Published: January 2019

Abstract
The prevalence of azole-resistant Aspergillus fumigatus (ARAF) in Japan is unclear. We aimed to investigate the epidemiology of clinically isolated Aspergillus species and the frequency of azole resistance in Aspergillus species, particularly Aspergillus fumigatus, in the Kyoto and Shiga regions of Japan. Strains of clinically isolated Aspergillus species were prospectively collected from nine acute care hospitals. Species identification was performed by DNA sequence analysis, and all strains were subjected to antifungal susceptibility testing. Sequencing of the Aspergillus cyp51A gene and promoter region and genotyping by short tandem repeats were performed for ARAF isolates. A total of 149 strains were collected, and 130 strains were included for the subsequent analysis after the exclusion of duplicate isolates. The most commonly isolated species was Aspergillus fumigatus, accounting for 43.1% (56 isolates) overall, and seven (12.7%) of 55 strains of A. fumigatus were azole-resistant. Azole-resistance of other Aspergillus species were also found that two (22.2%) of nine strains of A. tubingensis and two (28.6%) of seven strains of A. flavus were azole-resistant. DNA sequence analysis of the ARAF strains revealed that two carried the cyp51A TR34/L98H mutation, one carried G448S, one carried M220I, and three had no relevant mutations (wild type). Genotyping and phylogenetic analyses showed that the TR34/L98H strains were clustered with the strains from the Netherlands and France. These data suggest the emergence of ARAF with TR34/L98H in Japan, and continuous surveillance will be important to identify trends in resistance.
The Use of Anterior Lumbosacral Interbody Fusion in Spinopelvic Stabilization After High Partial Sacrectomy
Authors: Kashlan Osama N , Monson David K , Refai Daniel 
Published: January 2019

Abstract

BACKGROUND AND IMPORTANCE
Traditionally, when a patient presents with a midline chordoma with extension to the mid-S1 body where neither S1 nerve roots can be spared, the recommendation would be to perform a total sacrectomy for en bloc resection. This procedure, however, results in a large bony defect that makes it difficult to achieve fusion across the lumbosacral and sacroiliac junction (SIJ). To help prevent this challenge in the situation described above, we propose performing a high sacrectomy for en bloc resection with placement of an anterior L5-S1 graft instead in specific situations where the tumor extends to the mid-S1 body leaving the superior aspect of S1 unaffected.

CLINICAL PRESENTATION
A 56-yr-old female presented to our clinic with back pain, leg pain, urinary incontinence, and perineal numbness. She was found to have a chordoma that extended to the mid-S1 body superiorly. Her S1 nerve roots were involved extraforaminally. We performed the operation described above with no signs of hardware malfunction or tumor recurrence at 5 mo.

CONCLUSION
In patients where the sacral tumor that involves the S1 nerve roots but does not involve the superior portion of the S1 body, there continues to be unaffected SIJ to allow for arthrodesis, and an anterior approach is necessary for other indications, we recommend performing a high partial sacrectomy with placement of an anterior L5-S1 graft rather than a total sacrectomy as long as the bony resection offers ability to obtain tumor margins.
Can Medium-Resolution Satellite Imagery Measure Economic Activity at Small Geographies? Evidence from Landsat in Vietnam
Authors: Goldblatt Ran , Heilmann Kilian , Vaizman Yonatan 
Published: January 2019

AbstractThis study explores the potential and the limits of medium-resolution satellite data as a proxy for economic activity at small geographic units. Using a commune-level dataset from Vietnam, it compares the performance of commonly used nightlight data and higher resolution Landsat imagery, which measures daytime light reflection. The analysis suggests that Landsat outperforms nighttime lights at predicting enterprise counts, employment, and expenditure in simple regression models. A parsimonious combination of the first two moments of the Landsat spectral bands can explain a reasonable share of the variation in economic activity in the cross-section. There is, however, poor prediction power of either satellite measure for changes over time.
The time-course of component processes of selective attention
Authors: Wen Tanya , Duncan John , Mitchell Daniel J 
Published: January 2019

AbstractAttentional selection shapes human perception, enhancing relevant information, according to behavioral goals. While many studies have investigated individual neural signatures of attention, here we used multivariate decoding of electrophysiological brain responses (MEG/EEG) to track and compare multiple component processes of selective attention. Auditory cues instructed participants to select a particular visual target, embedded within a subsequent stream of displays. Combining single and multi-item displays with different types of distractors allowed multiple aspects of information content to be decoded, distinguishing distinct components of attention, as the selection process evolved. Although the task required comparison of items to an attentional “template” held in memory, signals consistent with such a template were largely undetectable throughout the preparatory period but re-emerged after presentation of a non-target choice display. Choice displays evoked strong neural representation of multiple target features, evolving over different timescales. We quantified five distinct processing operations with different time-courses. First, visual properties of the stimulus were strongly represented. Second, the candidate target was rapidly identified and localized in multi-item displays, providing the earliest evidence of modulation by behavioral relevance. Third, the identity of the target continued to be enhanced, relative to distractors. Fourth, only later was the behavioral significance of the target explicitly represented in single-item displays. Finally, if the target was not identified and search was to be resumed, then an attentional template was weakly reactivated. The observation that an item’s behavioral relevance directs attention in multi-item displays prior to explicit representation of target/non-target status in single-item displays is consistent with two-stage models of attention.