bluuebunny/crossref_metadata_2025_split huggingface dataset:
Recent planning approaches and mobility concepts for home health care services in Austria – A review
Authors: Hirsch Patrick 
Published: April 2018

Summary
Home health care (HHC) services are faced with a rising demand in Austria. This is due to an increased life expectancy, changing family structures, and the trend to grow old at home. The percentage of their working time that is spent by the HHC staff for travelling from one client to the next one reaches 30% and even more in some rural areas. Changing the assignment of HHC staff to clients and the sequence of visits can lead to major reductions in the travel distances, and therefore, to more sustainable solutions. The aim of this paper is to provide a comprehensive overview on the logistical planning of HHC services in Austria. In order to meet the future requirements, it is important to analyze different mobility concepts for the HHC staff and to provide tailored solution approaches for routing and scheduling. The reader learns about the current HHC situation in Austria, the logistical requirements for planning these services, possible mobility concepts for the HHC staff, and potential threats for HHC operations. The developed solution methods are presented in brief and the main findings are highlighted and discussed. The paper concludes with an outlook on potential future research paths in HHC routing and scheduling.
Comparison of organic and conventional crop yields in Austria
Authors: Brückler Martin , Resl Thomas , Reindl Andreas 
Published: April 2018

Summary
Organic farming represents an integral part of agriculture in Austria. The share of organic holdings and the share of area being organically farmed are already high relative to other countries within the European Union. So far, analyses of the organic sector have mainly focused on the economic output and the utilised area; less is known about absolute crop yields per hectare and the gap between organic and conventional crop yields. Given their relevance for profitability calculations and production strategies, such data is of major interest for farmers, advisors, and decision-makers. To address this lack of knowledge, we combine the Austrian farm accountancy data and Integrated Administration and Control System data for Austria. This paper presents a statistical analysis of organic crop yield data for the national Austrian territory as well as for regional categories and covers the period from 2003–2016. The results show a significant difference in crop yields: i) between organic and conventional farming systems; ii) between regional categories in Austria. Organic cereals achieve 35% lower average crop yields than conventional systems, yields for organic root and tuber crops were 27–49% lower. Yield gaps of oilseed and protein crops vary widely between respective crop species.
Eye-tracking test design influences the relationship between gazing behaviour and evaluation decision
Authors: Vu Thi Minh Hang , Tu Viet Phu , Duerrschmid Klaus 
Published: April 2018

SummaryRecent research has revealed a correlation between consumer gazing behaviour and decision-making in eye-tracking tests, which suggested a predictability decision-making from gazing behaviour. Since the eye-tracking test design has been reported to have an effect on gazing behaviour, the objective of this work is therefore to study systematically whether the test design influences the relationship between choice and gazing. Using a Tobii-T60 Eye Tracker, 100 persons participated in eye-tracking tests working on food images. Two design factors were tested: 1) Type of evaluation (maximum choice,minimum choice,ranking,and rating); 2) Question content (deliciousness,healthiness,prices,and familiarity). The results showed that the correlation between decision-making and gazing behaviour is influenced by bothType of evaluationandQuestion content. Only in the choice tests, a significant correlation between gazing behaviour and consumer decision-making was found. No correlation was found in the question content group Prices, but a very strong correlation existed in the three other question content groups. The results are discussed considering the relationship between visual attention and cognitive processes in decision-making.
Changes in forest landscape due to agricultural activities and their influence on natural ecosystems: the eastern Galician mountains
Authors: Diaz-Maroto I.J. , Diaz-Maroto M.C. 
Published: April 2018

AbstractForest and agricultural landscapes are vital in relation to biodiversity. Protection policies in such areas should include incentives to enable the common landuse practices. Conservation cannot be addressed in the short term because these landscapes have evolved as socio-ecological systems and provide optimal conditions for biodiversity maintenance. They occur in areas where agriculture has not changed significantly as in the eastern Galician mountains. The landscape dynamics has been shaped by human involvement during centuries. We analyzed how the landscape has evolved according to environmental, socioeconomic and historical changes with the aim of proposing actions for its conservation. The study focused on the recovery of natural hardwood forests which have been intensively exploited since ancient times. Over the past few centuries, these forests have been transformed to agricultural land, felled for use in the naval, metallurgical and railway industries, expropriated from the Church, and affected by wildfire; more recently, have been replaced by fast growing species. Today, broadleaved forests cover small areas of rugged land where the topography often precludes other land uses. In conclusion, although the landscape in the study area has undergone a major transformation, now this land is a priority for biodiversity conservation.
Telomere biology and age-related diseases
Authors: Herrmann Markus , Pusceddu Irene , März Winfried , Herrmann Wolfgang 
Published: April 2018

AbstractTelomeres are the protective end caps of chromosomes and shorten with every cell division. Telomere length has been proposed as a biomarker of biological age and a risk factor for age-related diseases. Epidemiologic studies show an association between leukocyte telomere length (LTL) and mortality. There is solid evidence that links LTL with cardiovascular disease. Short telomeres promote atherosclerosis and impair the repair of vascular lesions. Alzheimer’s disease patients have also a reduced LTL. Telomeres measured in tumor tissue from breast, colon and prostate are shorter than in healthy tissue from the same organ and the same patient. In healthy tissue directly adjacent to these tumors, telomeres are also shorter than in cells that are more distant from the cancerous lesion. A reduced telomere length in cancer tissue from breast, colon and prostate is associated with an advanced disease state at diagnosis, faster disease progression and poorer survival. By contrast, results regarding LTL and cancer are inconsistent. Furthermore, the majority of studies did not find significant associations between LTL, bone mineral density (BMD) and osteoporosis. The present manuscript gives an overview about our current understanding of telomere biology and reviews existing knowledge regarding the relationship between telomere length and age-related diseases.
Salivary biomarkers and cardiovascular disease: a systematic review
Authors: Gohel Vishal , Jones Judith A. , Wehler Carolyn J. 
Published: April 2018

AbstractBackground:The purpose of this systematic review is to summarize the literature examining associations between salivary biomarkers and cardiovascular disease (CVD) status.Contents:An advanced search was conducted using MeSH terms related to salivary biomarkers and CVD, and entered into the PubMed, Web of Science, and Google Scholar search databases. Four hundred and thirty-three records were narrowed to 22 accepted articles. Included titles were assessed for quality using the Newcastle-Ottawa scale, and ranked into categories of low, moderate, or high.Summary:A total of 40 salivary biomarkers were analyzed among accepted articles. The most studied markers were salivary creatine kinase isoform MB, C-reactive protein (CRP), matrix metalloproteinase-9, troponin I, myeloperoxidase, myoglobin, and brain natriuretic peptide. Salivary CRP provided the most consistent trends. Statistically significant increases of salivary CRP were present with CVD in every study that analyzed it. The remaining six markers demonstrated varying patterns.Outlook:Existing studies provide insufficient data to draw definitive conclusions. Current research shows that there is an association between some salivary biomarkers and CVD, but the details of existing studies are conflicting. Despite inconclusive results, the diagnostic potential of saliva shows promise as a non-invasive means of cardiovascular risk assessment.
Assessing matrix, interferences and comparability between the Abbott Diagnostics and the Beckman Coulter high-sensitivity cardiac troponin I assays
Authors: Kavsak Peter A. , Malinowski Paul , Roy Chantele , Clark Lorna , Lamers Shana 
Published: April 2018

AbstractBackground:Analytical evaluation of high-sensitivity cardiac troponin (hs-cTn) assays, with particular attention to imprecision, interferences and matrix effects, at normal cTn concentrations, is of utmost importance as many different clinical algorithms use concentration cutoffs <10 ng/L for decision-making. The objective for the present analytical study was to compare the new Beckman Coulter hs-cTnI assay (Access hsTnI) to Abbott’s hs-cTnI assay in different matrices and for different interferences, with a focus on concentrations <10 ng/L.Methods:The limit of blank (LoB) and the limit of detection (LoD) were determined in different matrices for the Beckman hs-cTnI assay. Passing-Bablok regression and difference plots were determined for 200 matched lithium heparin and EDTA plasma samples for the Beckman assay and 200 lithium heparin samples for the Abbott assay. Both EDTA and heparin plasma samples were also evaluated for stability under refrigerated conditions, for endogenous alkaline phosphatase interference and for hemolysis and icterus.Results:The Beckman hs-cTnI assay LoB was 0.5 ng/L with the following range of LoDs=0.8–1.2 ng/L, with EDTA plasma yielding lower concentrations as compared to lithium heparin plasma (mean difference=−14.9%; 95% CI=−16.9 to 12.9). Below 10 ng/L, lithium heparin cTnI results from the Beckman assay were on average 1.1 ng/L (95% CI=0.7 to 1.5) higher than the Abbott results, with no difference between the methods when using EDTA plasma (mean difference =−0.1 ng/L; 95% CI=−0.3 to 0.2). Low cTnI concentrations were less effected by interferences in EDTA plasma.Conclusions:The Access hsTnI method can reliably detect normal cTnI concentrations with both lithium heparin and EDTA plasma being suitable matrices.
Exploring the microbiota to better understand gastrointestinal cancers physiology
Authors: Panebianco Concetta , Potenza Adele , Andriulli Angelo , Pazienza Valerio 
Published: April 2018

Abstract
Gastrointestinal cancers account for around 40% of cancer-related deaths worldwide, representing a global health burden. There is a growing body of evidence highlighting the link between microbiota and gastrointestinal tumorigenesis and/or resistance to therapy. In the present manuscript, we reviewed the published studies on the relationship between the microbiota and the different gastrointestinal tumors, namely, gastric, colorectal and esophageal, including also the cancer of accessory organs such as liver and pancreas. There is an emergent interest in the manipulation of gastrointestinal microflora in order to understand the gastrointestinal tumorigenesis’ processes and the establishment of chemoresistance mechanisms.
Immunoglobulin G (IgG) and IgG subclass reference intervals in children, using Optilite® reagents
Authors: Grunewald Olivier , Lopez Benjamin , Brabant Séverine , Rogeau Stéphanie , Deschildre Antoine , Phrommavanh Vassana , Lefort Marie , Moitrot Emmanuelle , Gyselinckx Dominique , Deleplancque Anne-Sophie , Lefevre Guillaume , Labalette Myriam , Dubucquoi Sylvain 
Published: April 2018

Abstract

Background:
Immunoglobulin G (IgG) and IgG subclass assays are indicated in patients with suspected primary immunodeficiency (PID). Commercially available assays for IgG subclass determination are calibrated against various preparations, and so specific reference values are required for each of them. Using Optilite® reagents from The Binding Site Group Ltd., we sought to determine the pediatric IgG and IgG subclass reference intervals with respect to the ERM-DA470k certified reference material.

Methods:
Levels of IgG and IgG subclasses were analyzed in serum samples collected from a large cohort of PID-free children and adolescents. Reference intervals were calculated for previously published age groups (6–12 months, 12–18 months, 18 months–2 years, 2–3 years, 3–4 years, 4–6 years, 6–9 years, 9–12 years and 12–18 years), according to the Clinical and Laboratory Standards Institute’s C28-A3c protocol.

Results:
A total of 456 serum samples were analyzed. The correlation between the total IgG and the sum of the IgG subclasses was good (r2=0.96). No statistically significant gender-specific differences were observed. Our results for the changes over time in IgG and IgG subclass levels are consistent with previous reports. The differences between our lower/upper reference limits and those in the literature are probably due to variations in calibration.

Conclusions:
Our present results provide a reliable basis for the diagnosis of PIDs in childhood and for the accreditation of laboratories using Optilite® immunoturbidimetric reagents for IgG subclass measurement. Laboratory scientists and clinicians should be aware of the need for manufacturer-specific IgG subclass reference intervals.
Serum procalcitonin concentration within 2 days postoperatively accurately predicts outcome after liver resection
Authors: Aoki Yuto , Taniai Nobuhiko , Yoshioka Masato , Kawano Youichi , Shimizu Tetsuya , Kanda Tomohiro , Kondo Ryota , Kaneya Yohei , Furuki Hiroyasu , Uchida Eiji 
Published: April 2018

Abstract

Background:
Relatively high mortality and morbidity rates are reported after liver resection (LR). However, the early predictors of complications after LR are not clear. This study was performed to clarify the usefulness of procalcitonin (PCT) for the early prediction of complications after elective LR.

Methods:
This observational study included 72 consecutive patients who underwent elective LR from December 2015 to March 2017. Patients were categorized into two groups: those with and without postoperative complications (Clavien-Dindo grade ≥II). The values of postoperative inflammatory markers (white blood cell [WBC] count, C-reactive protein [CRP] and PCT) were compared between the two groups.

Results:
CRP and PCT were significantly higher in patients with than without complications; however, the WBC count showed no difference within 5 days postoperatively. The maximum area under the receiver operating characteristic curves within 2 days after LR using the WBC count, CRP and PCT were 0.608, 0.697 and 0.860, respectively, PCT had the best predictive ability in the early postoperative period. The PCT level peaked within 2 days postoperatively in 61 patients (85%). The maximum PCT level within 2 days postoperatively (PCT1−2) was significantly higher in patients with than without complications (0.52 vs. 0.19 ng/mL, p<0.001). A cutoff PCT1−2 level of 0.35 ng/mL achieved 80% sensitivity and 83% specificity. In patients without complications, there was no difference in PCT1−2 even when the surgical procedure differed (p=0.935).

Conclusions:
PCT1−2 is an early predictive marker after LR and can be similarly used regardless of the LR procedure.
Ultrastructural changes in murine liver following HSV infection and stroke
Authors: Motorna Natalia , Rybalko Svetlana , Kvitnitskaya-Ryzhova Tatyana , Starosyla Daria , Strokina Iryna , Kaminsky Rostyslav , Savosko Sergey , Sokurenko Liudmyla , Chaikovsky Yuri 
Published: April 2018

Abstract
The study of herpetic infection is a topical problem. Although the peculiarities and consequences of acute HSV-I infection in the brain are quite well-studied, little is known about the damage to other organs which are not a source of latent HSV-I infection, the liver in particular. The current study is aimed at determining the ultrastructural changes in murine liver following HSV infection and stroke. Liver samples obtained from four groups of animals were studied: 1) intact mice; 2) mice with stroke; 3) mice infected with HSV-I; 4) mice aflicted with HSV-I and subsequently simulated stroke. The study showed the reproduction of the virus in hepatic endotheliocytes, although no virions were detected in the hepatocytes. Therefore, the described changes were considered the consequences of the infectious process. Pathological changes of hepatocytes consisted of deformation and fragmentation of the nuclei, as well as accumulation of osmiophilic granules, lysosomes and lamellary bodies. Latent HSV-I infection may reactivate in liver after the stroke, potentially causing the complications of the underlying disease.
Evaluation of the impact of the proteasome inhibitor on calcium channel expression in cardiomyocytes treated with doxorubicin
Authors: Korga Agnieszka , Soroka Milena , Wicha Karolina , Humeniuk Ewelina , Adamczuk Grzegorz , Iwan Magdalena , Sysa Marcin , Dudka Jaroslaw 
Published: April 2018

Abstract
One of the less known mechanisms of doxorubicin action is the effect on the functioning of the ubiquitin-proteasome degradation system (UPS). So far, the role of impaired proteasome activity in the development of anthracycline cardiomyopathy has not been clarified. It has been shown, however, that doxorubicin decreases the expression of proteins, including the expression of the calcium channel. However, it has not been established whether the observed disturbances are due to the activation of the UPS system by doxorubicin, or due to inhibition of translation or transcription. Therefore, the aim of the study was to evaluate the mRNA and protein expression of plasmalemmal (NaCaX, L-type) and sarcoplasmic reticulum (SERCA2, RyR2) channels in rat embryonic cardiomyocytes treated with doxorubicin and the proteasome inhibitor – bortezomib. The study was conducted utilizing the rat cardiomyocyte H9C2 line that was treated with doxorubicin and bortezomib in different concentrations. After 24 hours incubation, mRNA and protein expression analysis followed. The study did not show any universal mechanism of doxorubicin influence on calcium channel expression. With regard to the Na/Ca exchanger, we saw that DOX decreased the protein level in a proteasome activitydependent manner. Moreover, we noted that the SERCA2 protein expression level was regulated by degradation intensity, however at the same time, no significant effect of doxorubicin on the level of this protein was demonstrated.
Apoptosis of rats’ cardiomyocytes after chronic energy drinks consumption
Authors: Slawinski Miroslaw Aleksander , Wawryk-Gawda Ewelina , Zarobkiewicz Michal Konrad , Halczuk Pawel , Jodlowska-Jedrych Barbara 
Published: April 2018

Abstract
Energy drinks (ED) are beverages containing caffeine, taurine, vitamins, herbal extracts, and sugar or sweeteners. They are marketed as capable of improving stamina, athletic performance and concentration, moreover, as serving as a source of energy. Still, there are very few papers describing the impact of ED on cell biology – including cell apoptosis within tissues. Therefore, in our study, we assessed the symptoms of rat cardiomyocytes apoptosis after 8 weeks consumption of ED.
For the research, we used male Wistar rats divided into 2 groups (experimental and control). The experimental animals received ED at a dose average of 0.190 ml per g of body weight per day for a period of 8 weeks. The animals of the control group received just water and food without limitation. After 8 weeks, the rats were decapitated; hearts and other organs were collected. After embedding in paraffin blocks, 5μm thick tissue slides were prepared and stained according to standard hematoxylin and eosine (H&E) staining protocol. Additional slides were stained by immunohistochemistry with antibodies directed against either caspaze-3 or p53 protein.
Our results showed that the expression of caspase 3 and p53 protein varied depending on the group of rats. The expression of caspase 3 observed in cardiomyocytes was much more intense in the experimental group compared to the control group. Furthermore, the immunoprecipitation of p53 protein was observed more frequently in the cardiomyocytes nuclei of the experimental group than in the control group.
Obtained results suggest that chronic use of ED induces intracellular disorders and apoptosis in consumer cardiomyocytes.
Stability indicating HPLC method for the simultaneous determination of dapagliflozin and saxagliptin in bulk and tablet dosage form
Authors: Deepan Thiyagarajan , Dhanaraju Magharla Dasaratha 
Published: April 2018

Abstract
A simple, fast, and highly selective RP-HPLC method was developed for the determination of Dapagliflozin (DAP) and Saxagliptin (SAX) in API and tablet dosage form. The separation was done using a Xterra RP18 (4.6×150 mm, 5 μm particle size) column with Acetonitrile: water (60:40). The isocratic elution mode at a flow rate of 1 mL/min, and the analytes were measured at 248 nm. The retention time for DAP and SAX were about 2.091 and 3.249 min, respectively. Calibration curves were found to be linear in the ranges of 100-500 μg/ml for DAP and 50-250 μg/ml for SAX, with correlation coefficients of 0.9998. The detection and quantification values for DAP was 3.0 and 9.98 μg/ml and SAX was 3.02 and 10 μg/ml respectively.
The Boundary Effect in the Accuracy Estimate for the Grid Solution of the Fractional Differential Equation
Authors: Makarov Volodymyr , Mayko Nataliya 
Published: April 2018

Abstract
A grid method for solving the first boundary value problem for ordinary and partial differential equations with the Riemann–Liouville fractional derivative is justified.
The algorithm is based on using Green’s function, the Fredholm integral equation, and the Lagrange interpolation polynomial.
The impact of the Dirichlet boundary condition on the accuracy of the approximate solution is revealed and quantitatively described through the weight assessment.
All the estimates provide clear evidence that the accuracy order of the grid method is higher near the boundary of the domain than it is in the inner nodes of the mesh set.
Online music recommendation platforms as representations of ontologies of musical taste
Authors: Krämer Benjamin 
Published: April 2018

Abstract
The framework of the ‘social ontology of the internet’ is applied to music recommendation platforms.
Those websites provide individual suggestions of music to users, creating new dynamics of taste that
are no longer based on human-to-human interaction and verbalized judgments. An exemplary analysis
of three platforms shows that different conceptions of musical tastes are represented by technical
systems: situational emotional preferences, a formalist aesthetics, and social proximity based on
tastes. The platforms share certain assumptions about the ontology of musical entities and of course
the constitutive act of recommending. We discuss how this act can be ascribed to technical systems.
Theses on the platforms’ effects on the social structure of musical tastes are developed.