bluuebunny/crossref_metadata_2025_split huggingface dataset:
Using Social Space Perspective to Explore SDGs Curricula Localisation: Case Study at Two Japanese National and Private Universities
Authors: Enkhtur Ariunaa , Rakhshandehroo Mahboubeh 
Published: November 2024

ABSTRACTDrawing on the concept of the Production of Space this article examines how sustainable development agenda was localised—in design, operation and students' lived experiences—in two international education programmes at two universities in Japan. We analysed relevant programme documents, interviews with faculty members, students' reflective notes, as well as the authors' autoethnographic journals. The findings show that the local and institutional context influenced the SDGs curriculum design (representations of space or the conceived space). The virtual and physical learning spaces, the pedagogy and the operation of the programme (spatial practice or perceived space) shaped students' interaction and learning outcomes (representational space or the lived space). As instructors attempted to adopt SDGs in their teaching (through perceived space) and as students tried to gain interdisciplinary knowledge through SDGs (through lived space), both parties negotiated and challenged the programme design shifting the conceived spaces. Our study contributes to a deeper understanding of the localisation of SDGs within the internationalisation of higher education by employing Lefebvre's spatial analysis. This approach reveals the complex socio‐spatial dynamics at play, offering insights into how educational environments are constructed and experienced.
Sinonasal adenosquamous carcinomas arising in seromucinous hamartoma or respiratory epithelial adenomatoid hamartoma with atypical features: Report of five detailed clinicopathological and molecular characterisation of rare entity
Authors: Bradová Martina , Costes‐Martineau Valerie , Laco Jan , Vaněček Tomáš , Grossmann Petr , Němcová Jana , Pavlovský Zdeněk , Skálová Alena , Michal Michal 
Published: November 2024

AimsSinonasal adenosquamous carcinoma (ASC) is a rare tumour classified as a variant of squamous cell carcinoma, exhibiting both squamous and glandular differentiation. ASC has a poorer prognosis compared to sinonasal mucoepidermoid carcinoma (MEC), another uncommon tumour in this region. ASC is believed to originate from metaplastic squamous epithelium, though it may also arise from respiratory epithelium in respiratory epithelial adenomatoid hamartoma (REAH) or seromucinous glands in seromucinous hamartoma (SH).Methods and resultsFive cases of sinonasal ASC were retrieved from our registry. Initially, they were classified as sinonasal MEC (n = 3), ASC (n = 2), and carcinoma ex REAH (n = 1). All cases showed adenosquamous malignant proliferation beneath the surface respiratory epithelium with occasional squamous metaplasia, except for one case that showed dysplasia. The respiratory epithelium exhibited an inverted growth pattern consistent with REAH/SH, and displayed atypical sinonasal glands (ASGSH) arising within seromucinous hamartoma. Next‐generation sequencing (NGS) revealed multiple pathogenic mutations in two cases, and in case 4 GGA2::PRKCB and EYA2::SERINC3 gene fusions. One case was positive for high‐risk HPV. None of the cases exhibited CRTC1/3::MAML2 gene fusion.ConclusionThe connection between ASGSH and ASC has not been described in the literature. There is a growing need for additional studies on the morphological, immunohistochemical, and genetic aspects of these tumours. SH/REAH may serve as precursor lesions in the progression of atypical sinonasal glands to malignancy, and their role in tumour development deserves further investigation.
Uncovering the impact of digital technologies on strategising: Evidence from a systematic literature review
Authors: Zhou Qijun , Yu Honglan , Adams Kweku , Attah‐Boakye Rexford , Johansson Jeaneth 
Published: November 2024

AbstractAdopting digital technologies in different organizations has become a trend over the last decade, yet our understanding regarding impact of digital technologies on strategising needs to be more cohesive. This paper reviews existing research on how digital transformation intersects with strategic management to adress this gap. Specifically, the aim is to explore how the digital context changes strategising. Based on a systematic review of empirical evidence from 163 journal papers, we showcased the manifestation of strategising in the digital age in terms of strategic practitioners, practices and praxis. By consolidating these findings, a typology of strategic actions in the digital age is developed and discussed, highlighting the interplay among changes in strategy‐as‐practice parameters. This framework clarifies in strategic scenarios of digital transformation and identifies various strategic directions and actions. Overall, we argue that although digital transformation has created additional strategic options, it has yet to change the underlying assumptions of strategising in firms.
LGR4 Deficiency Aggravates Skin Inflammation and Epidermal Hyperplasia in Imiquimod‐Induced Psoriasis
Authors: Xue Mengfei , Yang Ruijie , Li Guihong , Ni Zhizhan , Chao Yuqing , Shen Kairui , Ren Hua , Du Bing , Qin Juliang , Sun Zhenliang 
Published: November 2024

ABSTRACTPsoriasis is a chronic inflammatory skin disease characterised by inflammatory cell infiltration, keratinocyte hyperproliferation and increased neovascularization. Despite extensive research, the precise mechanisms underlying psoriasis pathology and treatment strategies remain unclear because of a complex aetiology and disease progression. Hence, in this study, we aimed to identify potential therapeutic targets for psoriasis and explore their effects on disease progression. We observed that G protein‐coupled receptor LGR4 attenuates psoriasis progression. Bioinformatics analysis of publicly available clinical data revealed lower LGR4 expression in the skin lesions of patients with psoriasis than in their non‐lesioned skin. Both in vitro (HaCaT cell) and in vivo (mouse) models confirmed this phenomenon. The Lgr4‐knockout mouse model further confirmed that LGR4 plays a positive role in psoriasis progression. Specifically, Lgr4 knockout promoted the secretion of inflammatory factors, accumulation of local immunocyte infiltration in skin lesions, and keratinocyte proliferation. In conclusion, we demonstrated that LGR4 is critical to limiting psoriasis progression, suggesting that it is a viable target for the clinical management of this skin condition.
Constructing a Predictive Model for Psychological Distress of Young‐ and Middle‐Aged Gynaecological Cancer Patients
Authors: Qu Yitong , Zhang Yinan , Zhou Xueying , Wang Linan , Zhu Xinran , Jin Shimei , Zhuang Shumei 
Published: November 2024

ABSTRACTBackgroundCancer patients experience substantial psychological distress which causes the reduction of the quality of life. However, the risk of psychological distress has not been well predicted especially in young‐ and middle‐aged gynaecological cancer patients. This study aimed to develop a prediction model for psychological distress in young‐ and middle‐aged gynaecological cancer patients using the artificial neural network (ANN).MethodsA cross‐sectional study of young‐ and middle‐aged gynaecological cancer patients (n = 368) was conducted between March and December 2022. We used the univariate analysis to determine the factors affecting psychological distress. ANN was used for psychological distress prediction in young‐ and middle‐aged gynaecological cancer patients. Also, a traditional logistic regression (LR) model was constructed for comparison. The area under the receiver's operating characteristic curve (AUC) was used to evaluate the model's predictive performance.ResultsANN and LR showed that self‐efficacy, economic income and sleep duration were the top risk variables for psychological distress in young‐ and middle‐aged gynaecological cancer patients. The AUC of the ANN was 0.977, the sensitivity was 94.83% and the specificity was 86.44%, whereas logistic regression's were 0.920, 85.57% and 82.76%, respectively.ConclusionCompared with the LR model, the ANN model shows obvious superiority across all assessment index outcomes, and it may be used as a decision‐support tool for early identification of young‐ and middle‐aged gynaecological cancer patients suffering from psychological distress.
Assessing the Role of Digital Literacy in Accessing and Utilising Virtual Healthcare Services: A Systematic Review Protocol
Authors: Hung Caitlin , Katapally Tarun Reddy 
Published: November 2024

ABSTRACTRationaleEmerging digital technologies are accelerating the transition of healthcare services from traditional in‐person settings to virtual platforms. As a result, digital literacy is becoming essential for individuals to effectively engage with these services. However, inadequate digital literacy poses a significant barrier to both accessing and utilising virtual healthcare, potentially widening existing health disparities.Aims and ObjectivesThis protocol outlines the approach for systematically reviewing and synthesising the existing literature on the influence of digital literacy on accessing and utilising virtual healthcare services.MethodsA comprehensive literature search will be conducted across five databases: Web of Science, Medline, Scopus, CINAHL and IEEE Xplore, covering publications from 2014 to 2024. The review will include all age cohorts and demographics, focusing on studies that examine digital literacy and measures of access to and utilisation of virtual healthcare services. Two independent reviewers will screen studies using pre‐determined search strategies for inclusion.ConclusionFindings from this study will provide valuable insights into the challenges and facilitators of digital literacy in engaging with virtual healthcare services. This review will also offer evidence‐based recommendations to optimise digital health interventions and promote inclusive, equitable healthcare delivery.
Swimming kinematics of deep‐sea fishes
Authors: Woodworth Brett , Palmeri Jessica , Flannery Patrick , Fregosi Lydia , Donatelli Cassandra , Gerringer Mackenzie E. 
Published: November 2024

AbstractAlthough the deep oceans represent Earth's largest habitat, the challenges of studying deep‐sea organisms in situ have limited our understanding of adaptation, ecology, and behaviour in these important ecosystems. One fundamental trait of fishes that remains largely unexplored in the deep ocean is swimming, a vital process for movement, migration, and dispersal in marine habitats. Deep‐sea conditions such as temperature, pressure, and food availability could each impact the speed and efficiency of swimming in fishes. To investigate swimming kinematics of fishes with increasing depth, we analysed in situ video of bony fishes across a 6000‐m depth gradient. We compared open‐source videos of fishes from National Oceanic and Atmospheric Administration (NOAA) Ocean Exploration with tank‐based recordings of shallow‐water relatives from Puget Sound, Washington, USA to understand how both habitat depth and phylogeny influence swimming in fishes. We analysed kinematics in four dominant demersal fish groups, the orders Anguilliformes, Gadiformes, Ophidiiformes, and Perciformes. Deep‐sea fishes swam consistently slowly. Swimming kinematics varied across temperature, oxygen, body elongation, and depth. These results suggest that swimming kinematics do not change linearly with increasing habitat depth in fishes and that the impacts of deep‐sea conditions such as low temperatures, high pressures, and low nutrient availability on swimming behaviour need to be considered independently of one another. These findings provide insight into the evolution of fish form and function in the deep ocean.
PLK2 inhibited oxidative stress and ameliorated hepatic ischemia–reperfusion injury through phosphorylating GSK3β
Authors: Ge Wenwen , Wang Zhoucheng , Zhong Xinyang , Chen Yutong , Tang Xiao , Zheng Shusen , Xu Xiao , Wang Kai 
Published: November 2024

AbstractBackground and AimHepatic ischemia–reperfusion (I/R) injury is the primary cause of liver dysfunction and liver failure, commonly occurring in liver transplantation, hepatectomy, and hemorrhagic shock. Polo‐like kinase 2 (PLK2), a pivotal regulator of centriole duplication, plays a crucial role in cell proliferation and injury repair. However, the function of PLK2 in hepatic I/R remains unclear.MethodsThe effect of PLK2 was investigated in the mouse hepatic I/R model and the hepatocyte hypoxia‐reoxygenation (H/R) model. Liver injury was assessed by serum transaminase and hematoxylin and eosin staining. Cell apoptosis was analyzed using TUNEL analysis and immunoblotting. Inflammatory factors were evaluated by reverse transcription‐quantitative polymerase chain reaction. Mice or cultured cells during the I/R or H/R were treated by overexpressing PLK2. ROS fluorescence staining was used to assess oxidative stress injury.ResultsPLK2 was upregulated after hepatic I/R injury. Overexpressed PLK2 significantly improved liver enzyme levels and alleviated liver histological injury. Moreover, PLK2 decreased hepatocyte apoptosis and inhibited the expression of inflammatory factors in liver. Mechanistically, PLK2 increased the phosphorylation of GSK3β and enhanced expression of the antioxidant enzyme HO‐1, leading to less ROS production. Inhibition of the HO‐1 aggravated ROS generation and abolished the protective effect of PLK2.ConclusionOverall, these findings revealed that PLK2 enhanced HO‐1 expression and reduced oxidative stress damage in hepatic I/R injury, and this protective effect related to GSK3β activity.
Quantifying whole human hair scalp fibres of varying curl: A micro‐computed tomographic study
Authors: Berg Claire van den , Khumalo Nonhlanhla P. , Ngoepe Malebogo N. 
Published: November 2024

AbstractScalp hair is a key feature of humans and its variability has been the subject of a broad range of studies. A small subset of these studies has focused on geometric quantification of human scalp hair fibres, however the use of race‐ and ethnicity‐based classification systems makes it challenging to draw objective conclusions about fibre variability. Furthermore, sample preparation techniques for micro‐imaging studies often alter the original form of hair fibres. This study sought to determine which of the commonly reported descriptors could be resolved using micro‐computed tomography (micro‐CT) for fibres of varying curl. Images obtained from micro‐CT were used to reconstruct three‐dimensional images that were then analysed. The study also explored the capabilities and limitations of micro‐CT as an imaging modality by comparing and cross‐validating findings with those obtained from scanning electron microscopy (SEM) and laser micrometry. The former deals with surface imaging while the latter deals with cross‐sectional measurements. Micro‐CT was found to be highly effective at resolving cross‐sectional ellipsoidal parameters, but performed more poorly than SEM in reconstructing surface level details at a 2 resolution. The technique was, however, able to reveal the presence of the medulla in type VI (high curl) hair fibres. When compared with high curl fibres, greater intra‐fibre variability was observed for the low and medium curl fibres, highlighting the importance more objective classification systems.
Current status of peptide receptor radionuclide therapy in grade 1 and 2 gastroenteropancreatic neuroendocrine tumours
Authors: Kuiper Jelka , Zoetelief Eline , Brabander Tessa , de Herder Wouter W. , Hofland Johannes 
Published: November 2024

AbstractPeptide receptor radionuclide therapy (PRRT) using [177Lu‐DOTA0,Tyr3]octreotate (177Lu‐DOTATATE) represents an established treatment modality for somatostatin receptor‐positive, locally advanced or metastatic gastroenteropancreatic neuroendocrine tumours (GEP NET) of grade 1 or 2. The studies have demonstrated that four cycles of PRRT with 177Lu‐DOTATATE prolongs progression‐free survival and preserves quality of life, in patients with grade 1 and 2 advanced GEP NET. Notably, first‐line PRRT using 177Lu‐DOTATATE in grade 2 and 3 GEP NET patients has also shown efficacy and safety. Furthermore, PRRT can ameliorate symptoms in patients with NET‐associated functioning syndromes. Although various studies have explored alternative radionuclides for PRRT, none currently meet the criteria for routine clinical implementation. Ongoing research aims to further enhance PRRT, and the results from large clinical trials comparing PRRT with other NET treatments are anticipated, potentially leading to significant modifications in NET treatment strategies and PRRT protocols. The results of these studies are likely to help address existing knowledge gaps in the coming years. This review describes the clinical practice, recent developments and future treatment options of PRRT in patients with grade 1 and 2 GEP NET.
Treatment of Cognitive Behavior Therapy for the Locus of Control with Internet Gaming Addiction Problem
Authors: Sugara Gian Sugiana , Nurfadila Ninda Amety , Arumsari Cucu , Rahimsyah Anandha Putri , Muhajirin Muhammad 
Published: November 2024

AbstractResearch has identified Internet gaming addiction as a new and often unrecognized clinical disorder that impacts users' ability to control Internet gaming use, which can lead to relational, work, and social problems. The locus of control is a factor in controlling the use of Internet games. Researchers have suggested using cognitive behavior therapy (CBT) as the treatment of choice for Internet addiction. This paper presents the findings of a study that utilized an A‐B‐A single‐case research design to explore the impact of CBT on enhancing internal locus of control and reducing Internet gaming addiction. The participants in this study were three high school students (N = 3) who exhibited a high level of Internet gaming addiction and a predominantly external locus of control. CBT intervention was provided in six sessions. Treatment focused on modified cognitive distortion and developing positive behavior using the down arrow technique, acting as if, shaping, problem‐solving, and behavior reinforcement. Participants completed the Game Addiction Scale for Adolescents and the Locus of Control Scale for Game Addiction. Data were obtained at three distinct phases: before, during, and after the CBT intervention. Results show that CBT reduced Internet gaming addiction and enhanced internal locus of control both during and after the intervention, indicating its potential as an effective treatment for students with gaming addiction issues.
Warfarin and Aspirin Versus Warfarin Alone in Patients With HeartMate 3 Left Ventricular Assist Device: A Systematic Review and Meta‐Analysis
Authors: Viana Patricia , Lopes Lucca Moreira , Cabral Thamiris Dias Delfino , Persson Jorge , Tapioca Vanessa de Oliveira , Freire Camila Veronica S. , Relvas Jessica Hoffmann , Mesquita Yasmin , Marques Isabela Reis , Gomes Wilton Francisco 
Published: November 2024

ABSTRACTBackground and AimsHeartMate 3 (HM3), a fully magnetically levitated ventricular assist device (LVAD), has been associated with reduced thromboembolic events compared to HeartMate II. However, bleeding events remained significant. Among patients undergoing HM3 implantation, the standard antithrombotic regimen comprises both warfarin and aspirin (ASA), but there is a lack of evidence on the optimum antithrombotic therapy. We performed a systematic review and meta‐analysis assessing the impact of combined ASA and warfarin therapy compared to warfarin alone on the incidence of non‐surgical bleeding events in patients with HM3 LVAD.MethodsMEDLINE, Embase, and Cochrane databases were searched for randomized controlled trials (RCTs) and observational studies comparing warfarin alone with warfarin combined with ASA in patients with HM3 LVAD. Binary endpoints were analyzed using computed risk ratios (RRs) with 95% confidence intervals (CIs). A random‐effect model was applied for all endpoints.ResultsFive studies (one RCT and four observational) encompassing 869 patients were included, with 424 (48.8%) prescribed warfarin alone, and 662 (76.2%) being male. Compared with the combined anticoagulation regimen, warfarin alone significantly reduced non‐surgical bleeding (RR 0.30; 95% CI 0.09–0.95; p = 0.04) and gastrointestinal bleeding (RR 0.26; 95% CI 0.12–0.58; p < 0.001). There was no statistically significant difference between the groups for all‐cause mortality (RR 1.02; 95% CI 0.45–2.32; p = 0.963).ConclusionsOur findings indicate that the use of warfarin alone for anticoagulation in HM3 patients is associated with a reduced risk of bleeding events when compared to the combined therapy with ASA.
Plant‐produced SARS‐CoV‐2 antibody engineered towards enhanced potency and in vivo efficacy
Authors: de Taeye Steven W. , Faye Loïc , Morel Bertrand , Schriek Angela I. , Umotoy Jeffrey C. , Yuan Meng , Kuzmina Natalia A. , Turner Hannah L. , Zhu Xueyong , Grünwald‐Gruber Clemens , Poniman Meliawati , Burger Judith A. , Caniels Tom G. , Fitchette Anne‐Catherine , Desgagnés Réjean , Stordeur Virginie , Mirande Lucie , Beauverger Guillaume , de Bree Godelieve , Ozorowski Gabriel , Ward Andrew B. , Wilson Ian A. , Bukreyev Alexander , Sanders Rogier W. , Vezina Louis‐Philippe , Beaumont Tim , van Gils Marit J. , Gomord Véronique 
Published: November 2024

SummaryPrevention of severe COVID‐19 disease by SARS‐CoV‐2 in high‐risk patients, such as immuno‐compromised individuals, can be achieved by administration of antibody prophylaxis, but producing antibodies can be costly. Plant expression platforms allow substantial lower production costs compared to traditional bio‐manufacturing platforms depending on mammalian cells in bioreactors. In this study, we describe the expression, production and purification of the originally human COVA2‐15 antibody in plants. Our plant‐produced mAbs demonstrated comparable neutralizing activity with COVA2‐15 produced in mammalian cells. Furthermore, they exhibited similar capacity to prevent SARS‐CoV‐2 infection in a hamster model. To further enhance these biosimilars, we performed three glyco‐ and protein engineering techniques. First, to increase antibody half‐life, we introduced YTE‐mutation in the Fc tail; second, optimization of N‐linked glycosylation by the addition of a C‐terminal ER‐retention motif (HDEL), and finally; production of mAb in plant production lines lacking β‐1,2‐xylosyltransferase and α‐1,3‐fucosyltransferase activities (FX‐KO). These engineered biosimilars exhibited optimized glycosylation, enhanced phagocytosis and NK cell activation capacity compared to conventional plant‐produced S15 and M15 biosimilars, in some cases outperforming mammalian cell produced COVA2‐15. These engineered antibodies hold great potential for enhancing in vivo efficacy of mAb treatment against COVID‐19 and provide a platform for the development of antibodies against other emerging viruses in a cost‐effective manner.