bluuebunny/crossref_metadata_2025_split huggingface dataset:
Brugerinddragelse i brug og integration af læringsplatforme
Authors: Dirckinck-Holmfeld Lone 
Published: August 2019

Artiklen undersøger, hvordan kombinationen af deltagende design og en ekspansiv læringstilgang kan guide processen med at integrere læringsplatformene i danske skoler. Hvordan er det muligt at etablere lokalt ejerskab, hvordan er det muligt at styrke de faglige og pædagogiske handlinger, og hvordan er det muligt at udvikle nye læringskulturer rammesat og støttet af de nye platforme? Dette kapitel skriver sig ind i det videnskabsfelt, som omhandler ”ibrugtagning” af teknologi, særligt den gren som udvikler begreber om forandring og transformation af professionel arbejdspraksis. Kapitlet har et særligt fokus på at undersøge, hvorledes fremtidsværkstedet som metode kan skabe indsigt i samt udvikle det pædagogiske personales engagement og ejerskab i forhold til en faglig, pædagogisk og organisatorisk brug af læringsplatforme.
Organic Fertilizers Effect on Potato (Solanum tuberosum L.) Tuber Production in Sandy Loam Soil
Authors: Ahmed Farid , Mondal M. Monjurul Alam , Akter Md. Babul 
Published: August 2019

Potatoes are one of the most common and important vegetable crops in the world and carrying different health benefits that make them all the more essential as a staple dietary item for much of the world’s population. The high nutrient content, ability to adapt to marginal environments, relative ease of cultivation and low cost and high productivity are attributes that make potatoes one of the principal and most important sources of food and income for developing countries. Considering the importance of organic manure for potato cultivation, the experiment was conducted to evaluate the effect of four organic fertilizers on potato tuber production in sandy loam soil. The most popular and easily available two potato cultivars namely Cardinal and Diamant and four organic fertilizers viz., cowdung at the rate of 8 t ha-1, chicken manure at the rate of 8 t ha-1, Rangpur Dinajpur Rural Service (RDRS) developed organic fertilizer at the rate of 740 kg ha-1 and Northern organic fertilizer at the rate of 500 kg ha-1 along with a control. The results revealed that the plant height, number of leaves, leaves fresh weight, yield contributing characters and yield were significantly different and higher in organic fertilizers over control. The highest plant height, leaf number, leaf fresh weight, total dry matter, absolute growth rate, tuber growth rate, tubers plant-1 and larger tuber size were observed in chicken manure which resulted the highest tuber yield (29.71 t ha-1) followed by cowdung (28.67 t ha-1) with same statistical rank. The third highest tuber yield was recorded in RDRS organic fertilizer (26.42 t ha-1) and Northern organic fertilizer (26.00 t ha-1). Besides, the potato cultivar, cardinal gave the highest tuber yield (26.39 t ha-1) compare to diamont (24.57 t ha-1). Finally, the potato cultivar cardinal and organic fertilizers, chicken manure followed by cowdung are recommended for potato cultivation in Rangpur region due to the highest yield production as well as maximum benefit-cost ratio.
A Bioprinted In Vitro Model for Osteoblast to Osteocyte Transformation by Changing Mechanical Properties of the ECM
Authors: Lee Bryan E. J. , Shahin‐Shamsabadi Alireza , Wong Michael K. , Raha Sandeep , Selvaganapathy Ponnambalam Ravi , Grandfield Kathryn 
Published: August 2019

AbstractOsteocytes are key contributors to bone remodeling. During the remodeling process, trapped osteoblasts undergo a phenotypic change to become osteocytes. The specific mechanisms by which osteocytes work are still debatable and models that exist to study them are sparse. This work presents an in vitro, bioprinted model based on the previously developed technique, ExCeL, in which a cell‐embedded hydrogel is printed and immediately crosslinked using paper as a crosslinker‐storing substrate. This process mimics the phenotypical change of osteoblast to osteocyte by altering the mechanical properties of the hydrogel. By printing Saos‐2, osteosarcoma cells, embedded in the alginate hydrogel with differing mechanical properties, their morphology, protein, and gene expression can be changed from osteoblast‐like to osteocyte‐like. The stiffer gel is 30 times stiffer and results in significantly smaller cells with reduced alkaline phosphatase activity and expression of osteoblast‐marker genes such as MMP9 and TIMP2. There is no change in viability between cells despite encapsulation in gels with different mechanical properties. The results show that the phenomenon of osteoblasts becoming encapsulated during the bone remodeling process can be replicated using the ExCeL bioprinting technique. This model has potential for studying how osteocytes can interact with external mechanical stimuli or drugs.
Instrumentiertes Feuchtemonitoring von historischen Bauwerken mittels elektrischer Impedanzspektroskopie
Authors: Krüger Markus , Lehmann Frank 
Published: August 2019

AbstractIm Rahmen mehrerer Forschungsprojekte zum Erhalt historischer Bauwerke wurde ein drahtloses Monitoringsystem für die kontinuierliche Bauwerksüberwachung entwickelt. Das System erlaubt die Verwendung einer Vielzahl von verschiedenen Sensoren sowohl zur Erfassung der Einwirkungen bzw. Umweltbedingungen, denen die historischen Objekte ausgesetzt sind, als auch der Bauwerksreaktion bzw. der Veränderungen am Bauwerk. Feuchtebedingte Schäden spielen dabei eine bedeutende Rolle und verursachen sehr hohe Kosten. Im vorliegenden Beitrag werden die Grundlagen zur instrumentierten Dauerüberwachung mittels drahtloser Sensornetze zur präventiven Konservierung vorgestellt und die Besonderheiten diskutiert, die auch bei der Weiterentwicklung von Monitoringsystemen berücksichtigt werden können. Die elektrische Impedanzspektroskopie bzw. Impedanzmessungen stellen dabei eine kostengünstige Möglichkeit zur qualitativen Feuchtemessung dar.
The impact of angiogenesis inhibitors on survival of patients with small cell lung cancer
Authors: Shi Xiaoshun , Dong Xiaoying , Young Sylvia , Chen Allen Menglin , Liu Xiguang , Zheng Zhouxia , Huang Kailing , Lu Di , Feng Siyang , Morahan Grant , Cai Kaican 
Published: August 2019

AbstractBackgroundSmall cell lung cancer (SCLC) is a highly invasive and lethal neuroendocrine tumor. Antiangiogenic drugs have been reported in the treatment of SCLC. We aimed to provide a comprehensive evaluation of the impact of angiogenic inhibitors on SCLC survival using network meta‐analysis.MethodsThe impact of five angiogenesis inhibitors, that is, vandetanib (Van), bevacizumab (Bev), Rh‐endostatin (End), sunitinib (Sun), and thalidomide (Tha), on progression‐free survival (PFS) and overall survival (OS) was evaluated by conducting a network meta‐analysis. RNA sequencing data were downloaded from publicly available databases.ResultsNine phase II and III randomized controlled trials (RCTs), that involved 1599 participants, that investigated angiogenesis inhibitors in the treatment of SCLC were included in this meta‐analysis. Sun and Bev achieved better PFS than Tha (Bev VS. Tha, HR = 0.88, 95% CI: 0.79‐0.98, Sun VS. Tha, HR = 0.80, 95% CI: 0.65‐1.00). Moreover, Sun and Bev were superior to placebo in terms of PFS (Bev VS. Placebo, HR = 0.89, 95%CI: 0.81‐0.97, Sun VS. Placebo, HR = 0.81, 95% CI: 0.66‐1.00). Based on this study, we found no significant difference of OS of SCLC. The angiogenesis pathway and expression of target genes were globally deactivated in SCLC tissue.ConclusionResults of this network meta‐analysis indicate that the PFS outcome of SCLC with Sun or Bev drugs is superior to that of Tha. The improved therapeutic impact of angiogenesis inhibitors on SCLC needs more evidence, such as long‐term observation in clinical trials, to be validated.
Percutaneous obliteration of the right ventricle to avoid coronary damage by sinusoids in patients with pulmonary atresia intact ventricular septum during staged single ventricle palliation
Authors: Hubrechts Jelena , Cools Bjorn , Brown Stephen C. , Eyskens Benedicte , Heying Ruth , Boshoff Derize , Gewillig Marc 
Published: August 2019

AbstractBackground and AimsSuprasystemic pressure waves can damage the coronary arteries resulting in myocardial ischemia and excess early mortality. We aimed to reduce the coronary pressure wave through the sinusoids by abolishing RV volume with percutaneous devices.Methods and ResultsFour patients with PA‐IVS and coronary sinusoids from the hypertensive rudimentary RV were evaluated at a median age 26.6 months (range: 2.7–51.7). Right ventricle coronary dependent flow to the left ventricular myocardium was excluded. All four patients had dual perfusion with competitive flow from the RV through the sinusoids to the coronary arteries. Devices used were: Amplatzer vascular plug II of 10–16 mm; 27 coils (diameter 5–15 mm) in the oldest patient. Right ventricular angiography after cavity obliteration showed no more significant coronary perfusion through the sinusoids. There were no complications or deaths. Only minor and transient changes in the levels of troponin were observed. Coronary angiography at pre‐Fontan evaluation showed no progress of coronary abnormalities in two patients.ConclusionIn selected patients with functionally single left ventricle, obliteration of the hypertensive RV cavity by percutaneous devices is safe and abolishes the systolic pressure wave in coronary sinusoids. When performed early, this may halt coronary damage and avoid excess mortality.
Fine‐needle aspiration cytology of the apocrine variant of epithelial‐myoepithelial carcinoma
Authors: Perez Diandra , Naous Rana 
Published: August 2019

AbstractEpithelial‐myoepithelial carcinoma (EMCa) is a rare neoplasm that most frequently afflicts the parotid gland. Histologically, a dual layer of inner, luminal epithelial cells and outer myoepithelial cells with associated background hyalinization characterize these tumors. Several variants of EMCa have been described, including the more recent description of the apocrine variant. We present here a case of a 71‐year‐old male with a parotid mass diagnosed on FNA as an apocrine epithelial‐myoepithelial carcinoma. To our knowledge, this is the first case report describing the cytomorphologic features of apocrine EMCa on FNA smears.
Oppia nitens C.L. Koch, 1836 (Acari: Oribatida): Current Status of Its Bionomics and Relevance as a Model Invertebrate in Soil Ecotoxicology
Authors: Fajana Hamzat O. , Gainer Amy , Jegede Olukayode O. , Awuah Kobby F. , Princz Juliska I. , Owojori Olugbenga J. , Siciliano Steven D. 
Published: August 2019

Abstract
The oribatid soil mite Oppia nitens C.L. Koch, 1836, is a model microarthropod in soil ecotoxicity testing. This species has a significant role in supporting soil functions and as a suitable indicator of soil contamination. Despite its significance to the environment and to ecotoxicology, however, very little is known of its biology, ecology, and suborganismal responses to contaminants in the soil. In the present review, we present detailed and critical insights into the biology and ecology of O. nitens in relation to traits that are crucial to its adaptive responses to contaminants in soil. We used a species sensitivity distribution model to rank the species sensitivity to heavy metals (cadmium and zinc) and neonicotinoids (imidacloprid and thiacloprid) compared with other standardized soil invertebrates. Although the International Organization for Standardization and Environment and Climate Change Canada are currently standardizing a protocol for the use of O. nitens in soil toxicity testing, we believe that O. nitens is limited as a model soil invertebrate until the molecular pathways associated with its response to contaminants are better understood. These pathways can only be elucidated with information from the mites’ genome or transcriptome, which is currently lacking. Despite this limitation, we propose a possible molecular pathway to metal tolerance and a putative adverse outcome pathway to heavy metal toxicity in O. nitens. Environ Toxicol Chem 2019;38:2593–2613. © 2019 SETAC
The Use of Geographic Information Systems for Spatial Ecological Risk Assessments: An Example from the Athabasca Oil Sands Area in Canada
Authors: Eccles Kristin M. , Pauli Bruce D. , Chan Hing Man 
Published: August 2019

Abstract
There is an acknowledged need in ecotoxicology for methods that integrate spatial analyses in risk assessment. This has resulted in the emergence of landscape ecotoxicology, a subdiscipline of ecotoxicology. However, landscape ecotoxicology has yet to become common practice in risk assessment due to the underdevelopment of techniques and a lack of standardized methods. In the present study, we demonstrate how geographic information systems (GISs) can serve as a standardized platform to integrate data, assess spatial patterns of ecotoxicological data for multiple species, and assess relationships between chemical mixture exposures and effects on biota for landscape ecotoxicological risks assessment. We use data collected under the Joint Oil Sands Monitoring Program in the Athabasca Oil Sands Region in Alberta, Canada. This dataset is composed of concentrations of contaminants including metals and polycyclic aromatic compounds, and health endpoints measured in 1100 biological samples, including tree swallows, amphibians, gull and tern eggs, plants, and mammals. We present 3 examples using a GIS as a platform and geospatial analysis to: 1) integrate data and assess spatial patterns of contaminant exposure in the region, 2) assess spatial patterns of exposures to complex mixtures, and 3) examine patterns of exposures and responses across the landscape. We summarize the methods used in the present study into a workflow for ease of use. The GIS methods allow researchers to identify hot spots of contamination, use georeferenced monitoring data to derive quantitative exposure-response relationships, and assess complex exposures with more realism. Environ Toxicol Chem 2019;38:2797–2810. © 2019 SETAC
Abstract
Chemical exposures to biota in regions of anthropogenic disturbance can be spatially assessed to quantity how exposures and responses vary across the landscape. These patterns and relationships can be used to inform and refine future biomonitoring programs.
Piezo1 regulates calcium oscillations and cytokine release from astrocytes
Authors: Velasco‐Estevez María , Rolle Sara O. , Mampay Myrthe , Dev Kumlesh K. , Sheridan Graham K. 
Published: August 2019

AbstractAstrocytes are important for information processing in the brain and they achieve this by fine‐tuning neuronal communication via continuous uptake and release of biochemical modulators of neurotransmission and synaptic plasticity. Often overlooked are their important functions in mechanosensation. Indeed, astrocytes can detect pathophysiological changes in the mechanical properties of injured, ageing, or degenerating brain tissue. We have recently shown that astrocytes surrounding mechanically‐stiff amyloid plaques upregulate the mechanosensitive ion channel, Piezo1. Moreover, ageing transgenic Alzheimer's rats harboring a chronic peripheral bacterial infection displayed enhanced Piezo1 expression in amyloid plaque‐reactive astrocytes of the hippocampus and cerebral cortex. Here, we have shown that the bacterial endotoxin, lipopolysaccharide (LPS), also upregulates Piezo1 in primary mouse cortical astrocyte cultures in vitro. Activation of Piezo1, via the small molecule agonist Yoda1, enhanced Ca2+ influx in both control and LPS‐stimulated astrocytes. Moreover, Yoda1 augmented intracellular Ca2+ oscillations but decreased subsequent Ca2+ influx in response to adenosine triphosphate (ATP) stimulation. Neither blocking nor activating Piezo1 affected cell viability. However, LPS‐stimulated astrocyte cultures exposed to the Piezo1 activator, Yoda1, migrated significantly slower than reactive astrocytes treated with the mechanosensitive channel‐blocking peptide, GsMTx4. Furthermore, our data show that activating Piezo1 channels inhibits the release of cytokines and chemokines, such as IL‐1β, TNFα, and fractalkine (CX3CL1), from LPS‐stimulated astrocyte cultures. Taken together, our results suggest that astrocytic Piezo1 upregulation may act to dampen neuroinflammation and could be a useful drug target for neuroinflammatory disorders of the brain.
Appraisal of the methodological quality of clinical practice guidelines in the Philippines
Authors: Miguel Red Thaddeus D. , Silvestre Maria Asuncion A. , Imperial Ma. Lourdes S. , Ho Beverly Lorraine C. , Dans Leonila F. 
Published: August 2019

SummaryPurposeThe Republic of the Philippines has recently enacted the Universal Health Care Law, which mandates the Philippines Department of Health (DOH) to operationalize evidence‐based clinical practice guideline (CPG) development. As a baseline to the foregoing task, the aim of this study was to appraise the methodological quality of CPGs previously developed and currently being disseminated in the Philippines. A multimethod search for CPGs was implemented. CPGs were independently evaluated using a modified version of the Knowledge Management Plus CPG appraisal tool.FindingsEighty‐seven CPGs were included in the appraisal. Majority implemented processes to ensure validity, ie, consideration for patient groups, management options, benefits, and harms (99%), and indicated strength of their recommendations (89%). Seventy‐seven CPGs (89%) evaluated the evidence for local applicability. Of the 87 CPGs, 20 CPGs (23%) considered equity in the development process. The development process differed among CPGs with varying degrees of utilization of GRADE methodology (52%), disclosure of funding sources (72%), and engagement of technical support external to the development body (3%). Mean duration of CPG development was 1 year (SD 5.9 months), and mean interval between updates was 6 years and 1 month (SD 37.8 months).ConclusionAlthough most of the CPGs fulfilled essential criteria for quality recommendations (validity and applicability), equity considerations were limited. Furthermore, only half used the GRADE approach and development and dissemination practices differed substantially between CPGs. Thus, it is recommended that a standard CPG development process be made available by the DOH to be utilized by CPG developers in the Philippines.
A Commercially Available Ruthenium Compound for Catalytic Hydrophosphination
Authors: Cibuzar Michael P. , Dannenberg Steven G. , Waterman Rory 
Published: August 2019

AbstractHydrophosphination with a commercially available ruthenium compound, bis(cyclopentadienylruthenium dicarbonyl) dimer ([CpRu(CO)2]2), was explored. Styrene derivatives or Michael acceptors react readily with either primary or secondary phosphines in the presence of 0.1 mol % of [CpRu(CO)2]2 under photolysis with an inexpensive and commercially available UV/A 9 W lamp. In comparison to related photoactivated hydrophosphination reactions with [CpFe(CO)2]2 as a catalyst, these ruthenium‐catalyzed reactions proceed at greater relative rates with lower catalyst loadings.
Recurrent massive myxoid liposarcoma in retroperitoneum 10 years post initial operation
Authors: Horiuchi Takamasa , Maekawa Shigekatsu , Obara Wataru , Kume Haruki , Matsuoka Naoki 
Published: August 2019

IntroductionMyxoid liposarcoma tends to be a relatively good prognosis. Follow‐up is recommended once a year from the 5th year after surgery.Case presentationA 48‐year‐old man had a massive retroperitoneal tumor, measuring approximately 20 cm. Resection of a huge myxoid liposarcoma had been performed on his back 10 years ago and the weight of the mass was 14 kg. The tumor was resected from the right kidney and its weight was 3.6 kg. Pathological examination showed myxoid liposarcoma and therefore, the tumor was diagnosed as recurrent. But after the resection, no recurrence or metastasis was observed.ConclusionTo our knowledge, the case presents the first report where both initial and recurrent tumors were massive and the time for recurrence was 10 years. Therefore, a follow‐up of myxoid liposarcoma might have to be done cautiously throughout the patient's life.
Clinical validation of the chronic liver disease questionnaire for the Chinese population in Singapore
Authors: Chang Pik‐Eu , Tan Hiang‐Keat , Lee Yean , Fook‐Chong Stephanie , Chia Pei‐Yuh , Shaik‐Hussain Nurshifa , Lee Hwei‐Ling , Aloweni Fazila 
Published: August 2019

Background and AimAssessment of health‐related quality‐of‐life (HRQOL) in patients with chronic liver disease (CLD) requires the use of validated instruments that are understood by patients in their native language. We previously translated the Chronic Liver Disease Questionnaire into the Singapore‐Mandarin version (CLDQ‐SG). This study aims to examine the internal consistency and validity of the CLDQ‐SG in patients with CLD.MethodsWe conducted a cross‐sectional study of adult patients with CLD seen in a tertiary center in Singapore who completed both the CLDQ‐SG and Short Form Health Survey 36 version 2 (SF‐36v2) questionnaires. Internal consistency of the CLDQ‐SG was assessed using Cronbach's alpha coefficient. Convergent and divergent validity of the SF‐36v2 was assessed using the Spearman correlation coefficient, while discriminant validity was assessed using the Jonckheere‐Terpstra test for trend. Exploratory factor analysis was performed to evaluate the factor structure of the CLDQ‐SG.ResultsWe enrolled 242 subjects (68.2% males, median age 67 years). Predominant etiology of CLD was chronic hepatitis B. Severity of CLD was divided into noncirrhotic (67.3%), compensated cirrhosis (24.0%), and decompensated cirrhosis (8.7%). Item convergent and discriminant validity of the CLDQ‐SG was excellent, with 100% scaling success in all six domains. All domains exhibited good internal consistency, with Cronbach's α > 0.70. We observed a consistent trend of a reduction in mean CLDQ‐SG score in the three groups reflecting the discriminant validity of the CLDQ‐SG to assess changes in HRQOL in different severities of CLD. Factor analysis of the CLDQ‐SG demonstrated an independent factor assessing sleep.ConclusionThe Singapore‐Mandarin version of CLDQ‐SG is a valid and reliable instrument to measure HRQOL in patients with CLD.
A comparative in silico analysis of Rab5 proteins from pathogenic species to find its role in the pathogenesis
Authors: Srivastava Vijay Kumar , Kaushik Sanket , Jyoti Anupam 
Published: August 2019

AbstractThe enteric protozoan parasite, Entamoeba histolytica (Eh), is the causative agent of amoebic dysentery and liver abscess in humans. It infects around 50 million people worldwide, which is a third general cause of death from parasitic diseases after malaria and schistosomiasis. The other prevalent form of the disease is Visceral leishmaniasis caused by Leishmania donovani which is a human blood parasite. On the other hand, the Toxoplasma gondii is an obligate intracellular protozoan parasite; it causes serious opportunistic infections in HIV‐positive persons. The biological processes in all living organisms are mostly mediated by the proteins, and recognizing new target proteins and finding their function in pathogenesis will help in choosing better diagnostic markers. In eukaryotes, Rab protein plays a major role in pathogenesis. Rabs represent the largest branch in the Ras superfamily of GTPases. Among them, the Rab5 is important in the endocytosis and thus involved in pathogenesis. In this paper, we discussed the physiochemical profiling, modelling, and docking of the Rab5 protein from pathogenic species that is Entamoeba histolytica, Leishmania donovani, and Toxoplasma gondii. The modeled structures from this study and the key residues identified would give a better understanding of the three‐dimensional structure and functional insights into these proteins and help in developing new drug targets.