bluuebunny/crossref_metadata_2025_split huggingface dataset:
Les ministres de Bercy, pilotes ou otages de la structure ?
Authors: Lambert Alain 
Published: February 2019

« Ministres pilotes ou otages ? » : cette question est régulièrement posée au sujet des ministres de Bercy. L’analyse pragmatique proposée observe que ces derniers disposent de tous les atouts et d’outils pour affirmer leur autorité, à condition qu’ils s’assument comme « responsables politiques » tant à l’endroit de la structure que des autorités qui leur sont supérieures. Et qu’au final le ministre le plus autonome sera celui qui n’aura pas demandé d’être nommé à ce poste.
Cycles de vie à Bercy
Authors: Siné Alexandre 
Published: February 2019

La longévité des ministres du Budget et de l’Économie et des Finances a tendance à se réduire sous la V e République, pour se porter à un niveau inférieur à deux ans. Système politique, trajectoires individuelles ou mise en œuvre des politiques publiques et des réformes en sont les causes. Si cette espérance de vie est analogue à celle des autres départements ministériels, elle est toutefois significativement inférieure à celle des ministres allemands et anglais, ce qui minore la continuité de la représentation française au niveau européen et réduit la capacité à incarner avec constance des politiques de long terme. Par ailleurs, le décalage entre le temps des politiques publiques et celui du ministre incite ce dernier au court-termisme. En revanche, Bercy est un tremplin politique qui permet d’accéder aux plus hautes fonctions de la République ou au sein d’institutions internationales.
Les personnels de Bercy
Authors: Pochard Marcel 
Published: February 2019

Les personnels de Bercy sont marqués du sceau de l’excellence, professionnellement et déontologiquement. Si leur régime de rémunération et d’œuvres sociales, avantageux par rapport au reste de la fonction publique, est à la mesure, tel n’est pas le cas de leur gestion, qui pose problème, entravée qu’elle est par des pesanteurs multiples, notamment corporatistes, qui réduisent singulièrement leur efficience, en particulier s’agissant des agents des deux grandes directions à réseau ( dgf i p et Direction générale des douanes et droits indirects). Une profonde mue de cette gestion a été engagée depuis la fin des années 1990, mais faute d’un « mandat politique clair », comme le dit la Cour des comptes, cette mue est encore loin de la transformation en profondeur qui s’impose.
Le ministre des Finances selon Gaston Jèze : États-Unis, Angleterre et Argentine
Authors: Bourget Renaud 
Published: February 2019

Invité à l’université de Buenos Aires en 1923 pour y prononcer une série de conférences, Gaston Jèze exposa le sens qui devait être celui des réformes à mener en Argentine, dont le système financier, pensait-il, tranchait, par les caractères obsolètes et surannés qu’il avait hérités de la période coloniale, avec le grand et riche pays qu’elle était devenue. Consacrant sa deuxième conférence aux fonctions du ministre des Finances argentin, Jèze devait décrire d’emblée la faiblesse de sa situation. C’est donc en Angleterre, pays de « l’équilibre budgétaire » et du « ministre des Finances fort », ainsi qu’aux États-Unis, dont le Congrès venait d’adopter une loi créant le Bureau of the Budget, qu’il trouva les exemples opportuns à suivre. Ce faisant, Jèze livra son « modèle » en la matière : le ministre des Finances doit avant tout être un « ministre de l’équilibre budgétaire ».
Human Blood and Tonsil Plasmacytoid Dendritic Cells Display Similar Gene Expression Profiles but Exhibit Differential Type I IFN Responses to Influenza A Virus Infection
Authors: Vangeti Sindhu , Gertow Jens , Yu Meng , Liu Sang , Baharom Faezzah , Scholz Saskia , Friberg Danielle , Starkhammar Magnus , Ahlberg Alexander , Smed-Sörensen Anna 
Published: February 2019

Abstract
Influenza A virus (IAV) infection constitutes an annual health burden across the globe. Plasmacytoid dendritic cells (PDCs) are central in antiviral defense because of their superior capacity to produce type I IFNs in response to viruses. Dendritic cells (DCs) differ depending on their anatomical location. However, only limited host-pathogen data are available from the initial site of infection in humans. In this study, we investigated how human tonsil PDCs, likely exposed to virus because of their location, responded to IAV infection compared with peripheral blood PDCs. In tonsils, unlike in blood, PDCs are the most frequent DC subset. Both tonsil and blood PDCs expressed several genes necessary for pathogen recognition and immune response, generally in a similar pattern. MxA, a protein that renders cells resistant to IAV infection, was detected in both tonsil and blood PDCs. However, despite steady-state MxA expression and contrary to previous reports, at high IAV concentrations (typically cytopathic to other immune cells), both tonsil and blood PDCs supported IAV infection. IAV exposure resulted in PDC maturation by upregulation of CD86 expression and IFN-α secretion. Interestingly, blood PDCs secreted 10-fold more IFN-α in response to IAV compared with tonsil PDCs. Tonsil PDCs also had a dampened cytokine response to purified TLR ligands compared with blood PDCs. Our findings suggest that tonsil PDCs may be less responsive to IAV than blood PDCs, highlighting the importance of studying immune cells at their proposed site of function.
FLEXamers: A Double Tag for Universal Generation of Versatile Peptide-MHC Multimers
Authors: Effenberger Manuel , Stengl Andreas , Schober Kilian , Gerget Maria , Kampick Maximilian , Müller Thomas R. , Schumacher Dominik , Helma Jonas , Leonhardt Heinrich , Busch Dirk H. 
Published: February 2019

Abstract
Peptide-MHC (pMHC) multimers have become a valuable tool for immunological research, clinical immune monitoring, and immunotherapeutic applications. Biotinylated tetramers, reversible Streptamers, or dye-conjugated pMHC multimers are distinct pMHC reagents tailored for T cell identification, traceless T cell isolation, or TCR characterization, respectively. The specific applicability of each pMHC-based reagent is made possible either through conjugation of probes or reversible multimerization in separate production processes, which is laborious, time-consuming, and prone to variability between the different types of pMHC reagents. This prohibits broad implementation of different types of pMHC reagents as a standard toolbox in routine clinical immune monitoring and immunotherapy. In this article, we describe a novel method for fast and standardized generation of any pMHC multimer reagent from a single precursor (“FLEXamer”). FLEXamers unite reversible multimerization and versatile probe conjugation through a novel double tag (Strep-tag for reversibility and Tub-tag for versatile probe conjugation). We demonstrate that FLEXamers can substitute conventional pMHC reagents in all state-of-the-art applications, considerably accelerating and standardizing production without sacrificing functional performance. Although FLEXamers significantly aid the applicability of pMHC-based reagents in routine workflows, the double tag also provides a universal tool for the investigation of transient molecular interactions in general.
The 1619 Dordrecht Synod’s decision on corruptio totalis: A missional challenge for the church in terms of media reporting on corruption in South Africa
Authors: Baron Eugene 
Published: February 2019

The doctrinal controversy, which led to the formal Synod in Dordrecht (1618–1619), had many stakeholders. The different European countries and its governments also had much at stake in terms of how the issue would have been dealt with by the Reformed Church. Although for different reasons than now, the controversy and the ultimate decision taken at the renowned Synod still has significance for the church and society in the 21st century and even beyond. Therefore, a recent study on the reporting of four South African newspapers on corruption (as a form of sin) is telling in terms of the way such cases are presented. Their reporting displays a different way of presenting ‘sin’ mainly as an actual sin and not as a human condition which calls for the church, in response to the missio Dei, to reflect theologically on contemporary media discourse on ‘sin’ if it wants to address the root cause of corruption in South Africa. Although I realise that there is other ways for the church to respond to widespread corruption, this article focuses mainly on a theological contribution in terms of a broader discussion on ‘sin’.
The Coal Beds of Generations X, Y, and Z: Syncing, Learning, and Propagating in the Age of the Posthuman
Authors: Govier Eloise 
Published: February 2019

ABSTRACTIn this article I broaden the discussion of posthuman pedagogy by arguing that when humans and Artificial Intelligences (AIs) engage, they are not separate entities but are instead “in-phenomena” (K. Barad, “Posthumanist Performativity: Toward an Understanding of How Matter Comes to Matter,” Signs: Journal of Women in Culture and Society 28[3] [2003]: 801–31). I contend that the division between humans and AI is artificial, and dispute the ontological separability of the two entities while they are in-phenomena. Instead, using anthropologist Tim Ingold’s notion of “correspondence-thinking,” I argue that humans and technology “sync up” and enter into “correspondence” (T. Ingold, “On Human Correspondence,” Journal of the Royal Anthropological Institute 23[1] [2017a]: 9–27). By doing so, I contend that the human body enters a different ontological category, which I describe using the neologism “humAIn.” I take inspiration from philosopher and physicist Karen Barad, and using her approach to causality and agency, contend that the ontological gap between human and AI is collapsed during “intra-actions.” Thus, the blood-filled veins of the human body and the blinking light of the metallic body coordinate and operate in unison—they are in sync. To explore the transient state humans enter while syncing with AIs, I outline ethnographic research carried out with the “chatterbot” hosted in my smartphone. While syncing with the device, I consider collaborative learning, a modality that attends to the role of education in wider society, and think through the repercussions of syncing for human–AI civic life. I argue that humAIn entities generate a valuable quasi-synthetic resource—proto-data—and these are the new coal beds of generations X, Y, and Z.
Application of relay puncture technique in treating patients with complicated lower extremity arterial diseases
Authors: Li Chengzhi , You Huimin , Zhang Hong , Liu Yulong , Li Wanghai , Wang Xiaobai , Zhang Yan 
Published: February 2019

Objective
This study aimed to introduce and evaluate the safety and efficacy of the relay puncture technique in patients with complicated lower extremity arterial diseases.

Methods
A total of 21 patients (16 male and five female patients; median age: 68.5 years old), who had suffered from lower extremity arterial diseases between December 2014 and July 2017, were retrospectively collected. For all patients, the contralateral femoral artery was not available for puncture access, and the length of the devices was too short for the brachial artery approach. Therefore, the relay puncture technique, in which the first puncture was performed on the brachial artery, followed by an antegrade puncture on the femoral artery, was used to accomplish the endovascular therapy. Percutaneous transluminal angioplasty and/or percutaneous transluminal stenting were/was used to assess the efficacy of the relay puncture technique. The ankle–brachial index (ABI) and Rutherford clinical classification were used to evaluate the improvement of symptoms after treatment. Patients were followed up for 1, 3, 6, and 12 months, and annually (mean: 16.6 months) after discharge.

Results
The relay puncture treatment had a 100% technical success rate, and immediately decreased the ischemic symptoms of patients after the procedure. The ABI significantly increased from 0.33 ± 0.18 to 0.75 ± 0.21 at the 1-year follow-up time point (P < 0.05). No serious complications occurred during the follow-up period. The 1-year primary patency rate was 71.43%.

Conclusion
The relay puncture technique is a feasible technique in the hands of experienced and skilled equipment operators for the treatment of lower extremity arterial diseases, when the contralateral femoral artery is not available for puncture, and the length of the device is too short to treat the distal lesion of the femoral artery and popliteal artery through the brachial artery approach.
A Study on the Role of Omega Fatty Acids as an Adjuvant Therapy in Treatment of Amblyopia
Authors: Sharda Shipra 
Published: February 2019

Aim:
To study the role of omega fatty acids as an adjuvant therapy in treatment of amblyopia.

Methods:
This prospective, randomized, interventional study included thirty two patients aged 5-12 years of age with unilateral amblyopia or bilateral amblyopia. One group (A) of sixteen patients were prescribed occlusion therapy and the other group (B) received 1000 mg per day of omega fatty acids along with occlusion for a period of three months. Follow-up assessments included best corrected visual acuity (BCVA) (both distance and near) and stereoacuity measurements at 1 week and end of three months.

Results:
The mean age of the patients was 8.68 ± 1.55 years. The mean baseline visual acuity for distance was 0.85 ± 0.071 Log MAR equivalent for Group A and 0.81 ± 0.073 Log MAR eq for Group B. At the end of therapy, the mean visual acuity was 0.48 ± 0.91 Log MAR eq and 0.40 ± 0.20 Log MAR equivalent for Group A and B respectively. There was statistically significant improvement in vision within Group A (p value-0.0008) and Group B (p value-0.0001). When both groups were compared, the results were insignificant (p value-0.373).

Conclusion:
Omega fatty acids improve visual acuity in patients with amblyopia and maintain improved visual acuity but there is no additional benefit when compared to patching alone. This study encourages further research on this subject.
Lipari Island
Authors: Depalmas Anna 
Published: February 2019

Abstract
Lipari is the largest of the Aeolian islands and there was an obsidian deposit which, since the early Neolithic period, was a source of trade in a broad area of the Mediterranean. The stratification of the castle's hill defines the occupation phases of the island up to the end of the later prehistoric settlement which was destroyed by invaders at the beginning of the Early Iron Age.
Herennius Modestinus
Authors: Cursi Maria Floriana 
Published: February 2019

AbstractModestinus was one of the most prominent jurists of the Severan age. He was Ulpian's student and in the so‐called Law of Citations his opinions were considered authoritative. He probably came from the Greek‐speaking East and held many important public positions related to his legal expertise. Many extracts of his works survive in the Justinianic Digest.
Improving fiducial and prostate capsule visualization for radiotherapy planning usingMRI
Authors: Pathmanathan Angela U. , Schmidt Maria A. , Brand Douglas H. , Kousi Evanthia , van As Nicholas J. , Tree Alison C. 
Published: February 2019

AbstractBackground and purposeIntraprostatic fiducial markers (FM) improve the accuracy of radiotherapy (RT) delivery. Here we assess geometric integrity and contouring consistency using a T2*‐weighted (T2*W) sequence alone, which allows visualization of theFM.Material and methodsTen patients scanned within the Prostate Advances in Comparative Evidence (PACE) trial (NCT01584258) had prostate images acquired with computed tomography (CT) and Magnetic Resonance (MR) Imaging: T2‐weighted (T2W) and T2*W sequences. The prostate was contoured independently on each imaging dataset by three clinicians. Interobserver variability was assessed using comparison indices with MonacoADMIRE(research version 2.0, ElektaAB) and examined for statistical differences between imaging sets.CTandMRimages of two test objects were acquired to assess geometric distortion and accuracy of marker positioning. The first was a linear test object comprising straight tubes in three orthogonal directions, the second was a smaller test object with markers suspended in gel.ResultsInterobserver variability for prostate contouring was lower for both T2W and T2*W compared toCT, this was statistically significant when comparingCTand T2*W images. All markers are visible in T2*W images with 29/30 correctly identified, only 3/30 are visible in T2W images. Assessment of geometric distortion revealed in‐plane displacements were under 0.375 mm inMRI, and through plane displacements could not be detected. The signal loss in theMRimages is symmetric in relation to the true marker position shown inCTimages.ConclusionProstate T2*W images are geometrically accurate, and yield consistent prostate contours. This single sequence can be used to identifyFMand for prostate delineation in a mixedMR‐CTworkflow.
A Review of Perovskites Solar Cell Stability
Authors: Wang Rui , Mujahid Muhammad , Duan Yu , Wang Zhao‐Kui , Xue Jingjing , Yang Yang 
Published: February 2019

AbstractIn this review, the factors influencing the power conversion efficiency (PCE) of perovskite solar cells (PSCs) is emphasized. The PCE of PSCs has remarkably increased from 3.8% to 23.7%, but on the other hand, poor stability is one of the main facets that creates a huge barrier in the commercialization of PSCs. Herein, a concise overview of the current efforts to enhance the stability of PSCs is provided; moreover, the degradation causes and mechanisms are summarized. The strategies to improve device stability are portrayed in terms of structural effects, a photoactive layer, hole‐ and electron‐transporting layers, electrode materials, and device encapsulation. Last but not least, the economic feasibility of PSCs is also vividly discussed.
In‐Flow MOF Lithography
Authors: Sevim Semih , Franco Carlos , Liu Hongjun , Roussel Hervé , Rapenne Laetitia , Rubio‐Zuazo Juan , Chen Xiang‐Zhong , Pané Salvador , Muñoz‐Rojas David , deMello Andrew J. , Puigmartí‐Luis Josep 
Published: February 2019

AbstractContinuous‐flow microfluidic systems are widely recognized as advanced and robust tools for materials synthesis. Indeed, the exquisite spatiotemporal control over reagent concentrations in a microfluidic channel has enabled the formation of composite materials and structures with unique features. Herein, we show for the first time that by combining reactive substrates with continuous‐flow microfluidic devices, material growth can be spatiotemporally driven and modulated on a surface. We demonstrate such unprecedented control by crystallizing and patterning compositional gradients of HKUST‐1 (a widely investigated metal‐organic framework (MOF)) on a reactive surface. We believe that this novel approach will engender new possibilities for incorporating MOFs on reactive surfaces, and thus for developing new advanced technological architectures and devices.
Theorizing Safety Informed Settings: Supporting Staff at Youth Residential Facilities
Authors: Sichel Corianna E. , Burson Esther , Javdani Shabnam , Godfrey Erin B. 
Published: February 2019

HighlightsWe outline the understudied challenges and needs of the Youth Residential Facility (YRF) workforce.Integrating trauma‐informed care and settings theory, we describe YRFs as trauma‐organized settings.We critique the person‐mediated emphasis of current trauma‐informed approaches.We make recommendations to shift problematic YRF regularities by focusing on safety, relationships, and YRF workforce well‐being.
Tracking of physical fitness in elementary school children: The role of changes in body fat
Authors: Werneck André O. , Silva Danilo R. , Oyeyemi Adewale L. , Fernandes Rômulo A. , Romanzini Marcelo , Cyrino Edilson S. , de Arruda Miguel , Ronque Enio R.V. 
Published: February 2019

AbstractObjectivesThe aim of the present study was to examine the stability of physical fitness, and the interrelationships among intra‐individual changes in fitness and fatness among elementary school children.MethodsA longitudinal study was conducted among 372 adolescents (196 boys) and followed up over 3 years (from childhood to adolescence). Physical fitness was estimated using three indicators: cardiorespiratory fitness (through a 9‐minute running test), flexibility (through a sit‐and‐reach test), and muscle resistance (through maximal abdominals in 1 minute). Body adiposity was obtained through triceps and subscapular skinfolds. Somatic maturation was assessed by the peak of height velocity. Kappa and Lin's tests of concordance as well as logistic regression analyses were conducted with P < 0.05 in STATA 15.1.ResultsTracking of physical fitness from childhood to adolescence was moderate for both sexes [boys: kappa = 0.441 (P < 0.001); LCCC = 0.591 (P < 0.001). Girls: kappa = 0.335 (P < 0.001); LCCC = 0.534 (P < 0.001)]. A larger increment in body fat was associated with a higher likelihood to decrease a tertile in physical fitness among boys [OR: 4.17 (95% CI: 1.31‐13.22)] and with a lower likelihood to increase a tertile in physical fitness among both sexes [boys: OR = 0.25 (95% CI: 0.09‐0.67); girls: OR: 0.37 (95% CI: 0.15‐0.92)].ConclusionsHealth‐related physical fitness has moderate tracking from childhood to adolescence. Increases in body adiposity from childhood to adolescence are associated with a reduction in physical fitness tertile.
Tailored Combinatorial Microcompartments through the Self‐Organization of Microobjects: Assembly, Characterization, and Cell Studies
Authors: Song Qimeng , Steuber Marc , Druzhinin Sergey I. , Schönherr Holger 
Published: February 2019

AbstractA new concept enables the generation of cell microenvironments by microobject assembly at an water/air interface. As the orientation of 30 μm sized polymer cubes and their capillary force assembly are controlled by the surface wettability, which in turn can be modulated by coating the initially exposed surfaces with gold and self‐assembled monolayers, unique niches in closely packed arrays of cubes with vertex up orientation can be realized. The random assembly of distinctly different cubes, prefunctionalized or surface‐structured exclusively on their top surface, facilitates the parallel generation of different microenvironments in a combinatorial manner, which paves the way to future systematic structure–property relationship studies with cells.
Zerovalent Rhodium and Iridium Silatranes Featuring Two‐Center, Three‐Electron Polar σ Bonds
Authors: Nance Patricia J. , Thompson Niklas B. , Oyala Paul H. , Peters Jonas C. 
Published: February 2019

AbstractSpecies with 2‐center, 3‐electron (2c/3e−) σ bonds are of interest owing to their fascinating electronic structures and potential for interesting reactivity patterns. Report here is the synthesis and characterization of a pair of zerovalent (d9) trigonal pyramidal Rh and Ir complexes that feature 2c/3e−σ bonds to the Si atom of a tripodal tris(phosphine)silatrane ligand. X‐ray diffraction, continuous wave and pulse electron paramagnetic resonance, density‐functional theory calculations, and reactivity studies have been used to characterize these electronically distinctive compounds. The data available highlight a 2c/3e−bonding framework with a σ*‐SOMO of metal 4‐ or 5dz2parentage that is partially stabilized by significant mixing with Si (3pz) and metal (5‐ or 6pz) orbitals. Metal‐ligand covalency thus buffers the expected destabilization of transition‐metal (TM)‐silyl σ*‐orbitals by d–p mixing, affording well‐characterized examples of TM–main group, and hence polar, 2c/3e−σ “half‐bonds”.