bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cobimetinib‐induced “dropped head syndrome” and subsequent disease management in an Erdheim‐Chester patient
Authors: King Amber C. , Diamond Eli L. , Orozco Jennifer S. , Morse Hannah R. , Ouyang Linda L. , Schöder Heiko , Rampal Raajit K. 
Published: September 2019

AbstractOur rechallenge of cobimetinib in an Erdheim‐Chester Disease (ECD) patient for the rare adverse effect, “dropped head syndrome,” with a previously unexplored cobimetinib regimen was successful. Similar to other experiences with targeted agents in ECD, dosing of cobimetinib may vary to mitigate toxicity without impairing efficacy.
Research on the Preparation of Graphdiyne and Its Derivatives
Authors: Xie Chipeng , Wang Ning , Li Xiaofang , Xu Guorong , Huang Changshui 
Published: September 2019

AbstractAs a new 2D carbon material allotrope composed of sp and sp2 carbon atoms, graphdiyne (GDY) possesses a highly conjugated porous structure, easily tunable intrinsic bandgap, and various excellent properties. Such properties allowed researchers to develop methods to prepare GDY, so that it can be applied for energy storage and conversion, environmental protection, various electronic devices and so on. In this review, the authors systematically discuss the methods and strategies developed for preparing GDY and its derivatives, including the synthesis of GDY by using liquid‐, solid‐, and gas‐phase methods, the synthesis of heteroatom‐doped GDY, the preparation of GDY‐based composites, and the synthesis of GDY analogues. All these preparation methods can provide the way to obtain GDY for specific studies and applications.
Towards the Development of Advanced Packing Design for Distillation in Rotating Packed Beds
Authors: Qammar Hina , Gładyszewski Konrad , Górak Andrzej , Skiborowski Mirko 
Published: September 2019

AbstractThe growing demand for flexible and compact separation technologies has promoted the application of high‐gravity technology, like rotating packed beds (RPBs). Mass transfer characterization and packing design play an important role in the development of this technology. This article provides a systematic approach towards the evaluation of packing and the development of advanced packing design for distillation in RPBs. For the latter, an additive manufacturing approach is used to develop a new Zickzack packing for RPBs. The new packing provides better mass transfer at reduced pressure drop compared to available conventional packings, while being competitive in terms of mass transfer with the industrially applied rotating zigzag bed at significantly reduced pressure drop.
Safety and efficacy of trabectedin when administered in the inpatient versus outpatient setting: Clinical considerations for outpatient administration of trabectedin
Authors: Jones Robin L. , Maki Robert G. , Patel Shreyaskumar R. , Wang George , McGowan Tracy A. , Shalaby Waleed S. , Knoblauch Roland E. , von Mehren Margaret , Demetri George D. 
Published: September 2019

BackgroundThe results of the randomized, phase 3 ET743‐SAR‐3007 trial demonstrated that trabectedin had a significantly longer progression‐free survival (PFS) compared with dacarbazine in patients with advanced leiomyosarcoma/liposarcoma after the failure of prior chemotherapy. Patients randomized to trabectedin received a 24‐hour intravenous infusion either in an inpatient or outpatient setting. Herein, the authors reported the safety, efficacy, and patient‐reported outcomes based on first infusion site of care.MethodsPatients were randomized 2:1 to trabectedin (at a dose of 1.5 mg/m2) or dacarbazine (1 g/m2 over 20‐120 minutes) with overall survival (OS) as the primary endpoint and PFS, time to disease progression, objective response rate, duration of response, safety, and patient‐reported symptom scoring as secondary endpoints. The setting of the trabectedin infusion was based on institutional preference and categorized based on the setting of the first infusion.ResultsOf the 378 patients who were treated with trabectedin, 100 (27%) and 277 (73%), respectively, first received trabectedin in the inpatient and outpatient setting. No differences were observed with regard to PFS or OS based on site of care. The median PFS was 4.1 months versus 4.2 months (hazard ratio, 0.90; P = .49) for inpatients versus outpatients, respectively, and the median OS was 14.3 months versus 13.7 months (hazard ratio, 0.89; P = .40), respectively. Grade 3/4 adverse events (classified according to the National Cancer Institute Common Terminology Criteria for Adverse Events [version 4.0]) were reported in 87 inpatients (87%) compared with 219 outpatients (79%); grade 3/4 serious adverse events were reported in 43 inpatients (43%) and 92 outpatients (33%). Extravasation occurred in 0 inpatients and 5 outpatients (2%), whereas the incidence of catheter‐related complications was similar between groups (16% vs 15%).ConclusionsAlthough the majority of patients who were randomized to trabectedin received outpatient therapy, the outcomes of the current study suggested equivalent safety and efficacy in either setting.
Axonal localization of the fragile X family of RNA binding proteins is conserved across mammals
Authors: Shepard Katherine A. , Korsak Lulu I T. , DeBartolo Danielle , Akins Michael R. 
Published: September 2019

AbstractSpatial segregation of proteins to neuronal axons arises in part from local translation of mRNAs that are first transported into axons in ribonucleoprotein particles (RNPs), complexes containing mRNAs and RNA binding proteins. Understanding the importance of local translation for a particular circuit requires not only identifying axonal RNPs and their mRNA cargoes, but also whether these RNPs are broadly conserved or restricted to only a few species. Fragile X granules (FXGs) are axonal RNPs containing the fragile X related family of RNA binding proteins along with ribosomes and specific mRNAs. FXGs were previously identified in mouse, rat, and human brains in a conserved subset of neuronal circuits but with species‐dependent developmental profiles. Here, we asked whether FXGs are a broadly conserved feature of the mammalian brain and sought to better understand the species‐dependent developmental expression pattern. We found FXGs in a conserved subset of neurons and circuits in the brains of every examined species that together include mammalian taxa separated by up to 160 million years of divergent evolution. A developmental analysis of rodents revealed that FXG expression in frontal cortex and olfactory bulb followed consistent patterns in all species examined. In contrast, FXGs in hippocampal mossy fibers increased in abundance across development for most species but decreased across development in guinea pigs and members of the Mus genus, animals that navigate particularly small home ranges in the wild. The widespread conservation of FXGs suggests that axonal translation is an ancient, conserved mechanism for regulating the proteome of mammalian axons.
Cooperatively Catalyzed Henry Reaction through Directed Metal‐Chitosan Interactions
Authors: Khoury Christine , Pappuru Sreenath , Gavriely Noa , Kleinerman Olga , Shpasser Dina , Segal‐Peretz Tamar , Gazit Oz M. 
Published: September 2019

AbstractThe main focus of the present work is on identifying the critical parameters involved in inducing acid‐base cooperative catalytic interaction in hybrid metal‐polymer materials. To makes these hybrid materials Ti or Sn acid sites are grafted to the hydroxy groups of chitosan (CS). The cooperative catalytic interactions between the Ti/Sn and the primary amine sites on CS are tested for the nitro‐aldol condensation of nitromethane with 4‐nitro‐benzaldehyde. The observed results show that the synthesis conditions have a pronounce effect on the 3D arrangement of the hybrid materials, which in turn affect the reaction activity and selectivity. The catalysts are characterized using N2‐pysisorption, XRD, FTIR, XPS and HRTEM in conjunctions with reaction kinetic analysis. Using the combined results, a reaction mechanism is proposed, which emphasizes the effect of proximity and orientation of the Lewis acid (Ti or Sn) and base (NH2) active sites on cooperative catalysis in the Henry reaction.
A bias‐compensated proportionate NLMS algorithm with noisy input signals
Authors: Yoo JinWoo , Shin JaeWook , Park PooGyeon 
Published: September 2019

SummaryThis paper proposes a novel proportionate normalized least‐mean‐squares (PNLMS) algorithm that is robust to input noises. Through compensating for biases due to input noise added at the filter input, the proposed PNLMS algorithm avoids performance deterioration owing to the noisy input signals. Moreover, since the proposed PNLMS algorithm uses a new gain‐distribution matrix, it has a fast convergence rate compared with the existing PNLMS algorithms, even when there is no input noise. The experimental results verify that the proposed PNLMS algorithm enhances the filter performance for sparse system identification in the presence of input noises.
Comparative analysis on pore‐scale permeability prediction on micro‐CT images of rock using numerical and empirical approaches
Authors: Song Rui , Wang Yao , Liu Jianjun , Cui Mengmeng , Lei Yun 
Published: September 2019

AbstractVarieties of pore‐scale numerical and empirical approaches have been proposed to predict the rock permeability when the pore structure is known, for example, microscopic computerized tomography (micro‐CT) technology. A comparative study on these approaches is conducted in this paper. A reference dataset of nine micro‐CT images of porous rocks is generated and processed including artificial sandpacks, tight sandstone, and carbonate. Multiple numerical and empirical approaches are used to compute the absolute permeability of micro‐CT images including the image voxel‐based solver (VBS), pore network model (PNM), Lattice Boltzmann method (LBM), Kozeny‐Carman (K‐C) equation, and Thomeer relation. Computational accuracy and efficiency of different numerical approaches are investigated. The results indicate that good agreements among numerical solvers are achieved for the sample with a homogeneous structure, while the disagreement increases with an increase in heterogeneity and complexity of pore structure. The LBM and VBS solver both have a relative higher computation accuracy, whereas the PNM solver is less accurate due to simplification on the topological structure. The computation efficiency of the different solver is generally computation resources dependent, and the PNM solver is the fastest, followed by VBS and LBM solver. As expected, empirical relation can over‐estimate permeability by a magnification of 50 or more, particularly for those strong heterogeneous structures reported in this study. Nevertheless, empirical relation is still applicable for artificial rocks.
Adjuvant therapies in the management of medication‐related osteonecrosis of the jaws: Systematic review
Authors: de Souza Tolentino Elen , de Castro Tamara F. , Michellon Felipe C. , Passoni Ana C. C. , Ortega Lorena J. A. , Iwaki Lilian C. V. , da Silva Mariliani C. 
Published: September 2019

AbstractBackgroundWe investigated the efficacy of hyperbaric oxygen (HBO), low‐intensity laser (LIL), and platelet‐rich plasma (PRP) in the management of medication‐related osteonecrosis of the jaws (MRONJ).MethodsA literature search was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta‐Analyses statement. Two examiners independently assessed eligibility and risk of bias and extracted data.ResultsThere was improvement in 75.6% of the 41 patients submitted to HBO, with positive effects on pain relief and decreased size and number of lesions at a faster rate, with better effects when the drug was discontinued. For LIL, 158 (64.2%) of the 246 patients/sites improved the symptoms and 98 (39.8%) healed completely. Fourteen (17.3%) of the 81 patients treated with PRP significantly improved the symptoms and 65 (80.2%) completely healed.ConclusionsThese therapies served as safe and effective adjuvant modalities for MRONJ treatment. The lack of randomized clinical trials evidences the need for more high‐quality investigations on the subject.
Effect on surgical decisions: Ulipristal acetate as key player in Belgian phase IV registration trial
Authors: Verguts Jasper , Godin Pierre Arnaud , De Vree Bart , Donnez Olivier , Cosyns Stefan , Luyckx Mathieu , Nisolle Michelle 
Published: September 2019

AbstractObjectiveTo observe alterations in surgical planning that were due to the use of ulipristal acetate (UPA) 5 mg daily for symptomatic uterine fibroids.MethodsA prospective cohort trial involving women with symptomatic fibroids was undertaken in 23 clinical practice sites within Belgium between October 1, 2014, and March 31, 2016, to compare initial surgical planning to performed surgical procedures following the use of UPA 5 mg daily for 3 months. Secondary outcomes were surgical complications, reduction in fibroids, bleeding control, and adverse effects.ResultsTwo hundred and twenty‐two women were recruited for the trial. The requirement for surgery decreased with the use of UPA, with 54% of women undergoing surgery after treatment. The reduction in surgery performed was lower for women willing to conceive (40%) compared to women who were not (49%). The volume of the fibroids decreased significantly, with the largest measured fibroid decreasing by 50%. Bleeding and pain were significantly decreased with the use of UPA. No major complications were recorded, and no liver function abnormalities were reported during the treatment and in follow‐up.ConclusionBy administering UPA, the required rate of surgery was significantly decreased. Also, the resulting reduction in size of the fibroids could have the potential benefit of reducing surgery‐related complications, and long‐term use may be warranted to avoid surgery completely.
The Importance of Biologically Active Vitamin D for Mineralization by Osteocytes After Parathyroidectomy for Renal Hyperparathyroidism
Authors: Yajima Aiji , Tsuchiya Ken , Burr David B , Wallace Joseph M , Damrath John D , Inaba Masaaki , Tominaga Yoshihiro , Satoh Shigeru , Nakayama Takashi , Tanizawa Tatsuhiko , Ogawa Hajime , Ito Akemi , Nitta Kosaku 
Published: September 2019

ABSTRACTHypomineralized matrix is a factor determining bone mineral density. Increased perilacunar hypomineralized bone area is caused by reduced mineralization by osteocytes. The importance of vitamin D in the mineralization by osteocytes was investigated in hemodialysis patients who underwent total parathyroidectomy (PTX) with immediate autotransplantation of diffuse hyperplastic parathyroid tissue. No previous reports on this subject exist. The study was conducted in 19 patients with renal hyperparathyroidism treated with PTX. In 15 patients, the serum calcium levels were maintained by subsequent administration of alfacalcidol (2.0 μg/day), i.v. calcium gluconate, and oral calcium carbonate for 4 weeks after PTX (group I). This was followed in a subset of 4 patients in group I by a reduced dose of 0.5 μg/day until 1 year following PTX; this was defined as group II. In the remaining 4 patients, who were not in group I, the serum calcium (Ca) levels were maintained without subsequent administration of alfacalcidol (group III). Transiliac bone biopsy specimens were obtained in all groups before and 3 or 4 weeks after PTX to evaluate the change of the hypomineralized bone area. In addition, patients from group II underwent a third bone biopsy 1 year following PTX. A significant decrease of perilacunar hypomineralized bone area was observed 3 or 4 weeks after PTX in all group I and II patients. The area was increased again in the group II patients 1 year following PTX. In group III patients, an increase of the hypomineralized bone area was observed 4 weeks after PTX. The maintenance of a proper dose of vitamin D is necessary for mineralization by osteocytes, which is important to increase bone mineral density after PTX for renal hyperparathyroidism. © 2019 The Authors. JBMR Plus published by Wiley Periodicals, Inc. on behalf of American Society for Bone and Mineral Research.
A CTGF-RUNX2-RANKL Axis in Breast and Prostate Cancer Cells Promotes Tumor Progression in Bone
Authors: Kim Bongjun , Kim Haemin , Jung Suhan , Moon Aree , Noh Dong-Young , Lee Zang Hee , Kim Hyung Joon , Kim Hong-Hee 
Published: September 2019

ABSTRACT
Metastasis to bone is a frequent occurrence in patients with breast and prostate cancers and inevitably threatens the patient's quality of life and survival. Identification of cancer-derived mediators of bone metastasis and osteolysis may lead to novel therapeutic strategies. In this study, we established highly bone-metastatic PC3 prostate and MDA-MB-231 (MDA) breast cancer cell sublines by in vivo selection in mice. In bone-metastatic cancer cells, the expression and secretion of connective tissue growth factor (CTGF) were highly upregulated. CTGF knockdown in bone-metastatic cells decreased invasion activity and MMP expression. RUNX2 overexpression in the CTGF knockdown cells restored the invasion activity and MMP expression. In addition, CTGF increased RUNX2 protein stability by inducing its acetylation via p300 acetyl transferase. The integrin αvβ3 receptor mediated these effects of CTGF. Furthermore, CTGF promoted RUNX2 recruitment to the RANKL promoter, resulting in increased RANKL production from the tumor cells and subsequent stimulation of osteoclastogenesis from precursor cells. In addition, animal model with injection of CTGF knocked-down prostate cancer cells into 6-week old BALB/c male mice showed reduced osteolytic lesions. More importantly, the expression levels of CTGF and RANKL showed a strong positive correlation in human primary breast tumor tissues and were higher in bone metastases than in other site metastases. These findings indicate that CTGF plays crucial roles for osteolytic bone metastasis both by enhancing invasiveness of tumor cells and by producing RANKL for osteoclastogenesis. Targeting CTGF may lead to the development of effective preventive and therapeutic strategies for osteolytic metastasis. © 2019 American Society for Bone and Mineral Research.
Secular Trends of Hip Fractures in Lebanon, 2006 to 2017: Implications for Clinical Practice and Public Health Policy in the Middle East Region
Authors: Saad Randa K , Harb Hilda , Bou-Orm Ibrahim R , Ammar Walid , El-Hajj Fuleihan Ghada 
Published: September 2019

ABSTRACT
Country-specific hip fracture incidence rates (IRs) and longevity allow the Fracture Risk Assessment Tool (FRAX) to be adapted to individual countries. Secular trends can affect tool calibration. Data on hip fracture IRs in the Middle East is scarce, and long-term secular trend studies are nonexistent. Using the Ministry of Public Health hip fracture registry, we calculated age- and sex-specific hip fracture IRs in Lebanon, from 2006 to 2017, among individuals aged ≥50 years. We used Kendall's tau-b (τb) test to determine the correlation between time and hip fracture IRs, and calculated both the annual % change in IRs and the % change in IR compared to the baseline period (2006 to 2008). The registry recorded 6985 hip fractures, 74% at the femoral neck, 23% intertrochanteric, and 3% subtrochanteric. Men constituted 32% of the population, and were significantly younger than women (76.5 ± 11.0 years versus 77.7 ± 10.3 years; p &lt; 0.001). Annual overall IRs, per 100,000, ranged from 126.6 in 2014 to 213.2 in 2017 in women, and 61.4 in 2015 to 111.7 in 2017 in men. The average women to men IR ratio was 1.8 (range, 1.5 to 2.1). IRs steadily increased with age, and IR ratios increased in parallel in both sexes, with a steeper and earlier rise (by 5 years) in women. Data showed a consistent decline in hip fracture IRs starting in 2006 in women, and in 2009 in men. There was a significant negative correlation between time (2006 to 2014) and hip fracture IRs in women (τb = −0.611, p = 0.022) but not in men (τb = −0.444, p = 0.095). The steady decrease in IRs reversed after 2015 in both sexes. This long-term data on secular trends in the Middle East is novel and consistent with worldwide changes in hip fracture rates. The impact of such changes on national FRAX-derived estimates is unclear, should be assessed, and may necessitate an update in the FRAX Lebanon calculator. © 2019 American Society for Bone and Mineral Research.
A six‐CpG‐based methylation markers for the diagnosis of ovarian cancer in blood
Authors: Wang Lei , Ni Sha , Du Zhenhua , Li Xiuqin 
Published: September 2019

AbstractDNA methylation markers in the peripheral blood are able to be applied to treat epithelial cancer. Nevertheless, the diagnostic potential value of it for ovarian cancer (OV) has not been studied. The study aimed to explore the difference of DNA methylation in peripheral blood between OV patients and healthy women. Firstly, the whole blood of DNA methylation data was provided by the Gene Expression Omnibus (GEO) database. The linear model was applied to the identification of significantly differentially expressed methylated CpG sites (differentially methylation sites [DMP]), and the further screen of co‐expression CpG sites (Co‐DMP). A total of 2812 DMPs were identified, and weighted gene co‐expression network analysis helped to obtain seven co‐expression modules. Among them, the yellow module was the most related to OV. Co‐DMPs (167) in the yellow module were mainly distributed near the transcription start sites. However, most of them were not in the CpG island. Least absolute shrinkage and selection operator (LASSO) regression analysis was applied to the identification of stable OV‐related blood biomarkers that six Co‐DMPs (cg00134539, cg00226923, cg25268718, cg25697314, cg25839227, cg26574610) with the highest frequency were found as potential biomarkers. Finally, the diagnostic classifier was established using the support vector machine (SVM) with the accuracy rate of 87.1% and 74.5% in training data set and validation data set, respectively. To sum up, a new feature was provided here for the diagnosis of OV, which is helpful for the diagnosis and individualized treatments of early OV.
Working through shame with an intercultural couple in Japan: Transforming negative emotional interactions and expanding positive emotional resources
Authors: Iwakabe Shigeru 
Published: September 2019

AbstractJapan is often described as an intricate yet contradictory society in which the elements of the most advanced technologies and ancient cultural traditions coexist. Social cohesion rooted in uniformity and ethnic purity has long been the implicit, normative ideal in Japan, while diversity as intrinsic value is still a relatively new concept. In this monocultural milieu, intercultural couples often encounter issues associated with culturally‐bound notions of gender roles and the societal pressure to conform to the implicit cultural ideal. The distress of unresolved past emotional injuries may also surface, which often results in the couple getting stuck in negative emotional cycles. This paper will discuss the case of Yoko and Frank, who were treated with an affect‐focused approach in which their emotional conflicts, particularly their feelings of shame, were worked through while each partner developed their self‐ and other‐emotion regulating capacity. The therapist also helped the couple develop new patterns of positive emotional interaction.