bluuebunny/crossref_metadata_2025_split huggingface dataset:
Outcomes following persistent atrial fibrillation ablation using localized sources identified with Ripple map
Authors: Melby Daniel P. , Gornick Charles , Abdelhadi Raed , Sengupta Jay , Pai Manju , Zakaib John S. , Moore JoEllyn , Benditt David G. 
Published: July 2019

AbstractBackgroundAblation of persistent atrial fibrillation (AF) remains challenging. Identification and ablation of localized AF drivers may offer the possibility for improved outcomes. Ripple map is a novel software algorithm that may allow improved localization of possible AF drivers through the whole chamber graphical display of continuously recorded bipolar electrograms. The objective of this study was to determine whether regions of high‐frequency Ripple activation (HFRA) observed on Ripple map provide useful ablation targets in patients with persistent AF.Methods and ResultsConsecutive patients underwent the first‐time ablation of persistent AF (n = 162) using a standard stepwise (n = 105) or a Ripple map guided approach (n = 57). Ripple map guided patients underwent pulmonary vein antral isolation followed by ablation of HFRA sites. Acute termination of AF was observed in 91.2% of the Ripple‐guided patients vs 52.4% in the stepwise approach, P < .0001. Following a single ablation procedure, after 18 months 98.2% of Ripple map guided patients were free of AF, compared with 81.4% of standard stepwise ablation (P = .005). Freedom from atrial tachycardia (54.4% Ripple map vs 52.4% standard, P = .9) or any atrial arrhythmia (52.6% Ripple map vs 39.0% standard, P = .10) did not differ between the two strategies. In a subset analysis (n = 30 of 56), Ripple map regions corresponded to sites with spatiotemporal dispersion in all atrial locations. No differences were observed in the rate of procedural complications.ConclusionsAblation of HFRA sites identified with Ripple map resulted in a higher rate of acute termination and improved freedom from AF compared to a standard stepwise approach.
Determinants of postoperative left atrial structural reverse remodeling in patients undergoing combined catheter ablation of atrial fibrillation and left atrial appendage closure procedure
Authors: Li Yi‐Gang , Gong Chang‐Qi , Zhao Ming‐Zhe , Sun Jian , Wang Qun‐Shan , Zhang Peng‐Pai , Feng Xiang‐Fei , Yu Yi , Yu Yi‐Chi , Liang Bing‐Er ,   and other members of the Xinhua Cardiac EP Study Group
Published: July 2019

AbstractIntroductionCatheter ablation of atrial fibrillation (AFCA) and left atrial appendage closure (LAAC) exert opposite effects on left atrial (LA) size. We aim to observe the net impact of combined AFCA and LAAC strategy on LA size and explore those factors which might affect the postprocedure LA structural remodeling.MethodsA total of 53 patients, who underwent combined AFCA and Watchman LAAC in our center from March to December 2017, were enrolled. Atrial fibrillation (AF) recurrence was monitored after the procedure. Left atrial volume (LAV) and left atrial appendage volume (LAAV) were measured by Mimics based on dual‐source computed tomography images.ResultsAt 6 months, sinus rhythm (SR) was maintained in 79.2% patients. LAV was significantly reduced (130.2 ± 36.3 mL to 107.1 ± 30.0 ml; P < .001) in SR maintenance group, but not in AF recurrence group (138.8 ± 39.3 mL to 137.9 ± 36.9 mL; P = .671). In SR group, preoperative LAAV/LAV ratio (B = −0.894; P = .015), NT‐proBNP (B = 0.005; P = .019) and left ventricular ejection fraction (LVEF) (B = −0.778; P < .001) could interactively affect the extent of postoperative LA structural reverse remodeling, among which LAAV/LAV ratio could independently predict the significance of reverse remodeling (≥15% reduction in LAV) (OR, 0.56; 95% CI, 0.34‐0.90; P = .018). A preoperative LAAV/LAV ratio less than 7.1% is indicative of significant LA structural reverse remodeling in this patient cohort.ConclusionsLA structural reverse remodeling could be evidenced in patients with maintained SR following combined AFCA and LAAC. Smaller LAAV/LAV ratio, higher NT‐proBNP or lower LVEF at baseline are associated with more significant LA structural reverse remodeling, while LAAV/LAV ratio can predict the significance of the process after one‐stop treatment.
Low‐cost healthy extrudates of rice and bhimkol (Musa balbisiana, ABB) formulated through linear programming
Authors: Borah Anjan , Das Deepjyoti K. , Hazarika Manuj K. , Mukhopadhyay Rupak , Mahanta Charu L. 
Published: July 2019

AbstractLow amylose rice, intermediate amylose rice, and seeded banana were taken for formulation of an extruded product using linear programming (LP) model. The model was designed to develop nutritious low‐cost extrudate products. The optimization for development of extrudates was performed by using central composite rotatable design (CCRD). The formulated extruded product developed at the optimized condition was found to have calorific value of 175 kcal/100 g and protein content of 6.35% with adequate amount of micro‐nutrients like magnesium (15.3 mg/100 g) and potassium (33.2 mg/100 g), respectively. Cytotoxicity assay with various levels of the extrudate showed negligible toxicity against human embryonic kidney (HEK293) cells.Practical ApplicationReady‐to‐eat (RTE) foods are becoming widely popular due to change in lifestyle. However, RTE products are basically cereal‐based and found to have low nutritional value. Thus, there is a need to increase protein and minerals in cereal‐based extruded cereals.
Voluntary Reserve Targets
Authors: BAUGHMAN GARTH , CARAPELLA FRANCESCA 
Published: July 2019

AbstractWe study monetary policy implementation through an operating regime involving voluntary reserve targets (VRTs). Operating regimes based on reserve requirements may lead to a collapse in interbank trade, as they have since the financial crisis. We show that, no matter the abundance of reserves, VRTs encourage market activity and support the central bank's control over interest rates. We consider (i) the impact of anticipated and unanticipated liquidity injections by the central bank on market outcomes and (ii) a comparison with the implementation framework currently adopted by the Federal Reserve. Overall, a VRT framework may provide several advantages over other frameworks.
Clinical factors associated with the recurrence of central giant cell lesions
Authors: Chrcanovic Bruno Ramos , Gomes Carolina Cavaliéri , dos Santos Thiago Rezende , Abreu Mauro Henrique Nogueira Guimarães , Gomez Ricardo Santiago 
Published: July 2019

AbstractCentral giant cell lesion of the jaws (CGCLJ) is a destructive condition that shows a varied and unpredictable biological behaviour. In the present study, we aimed to evaluate factors associated with the recurrence of CGCLJ. Based on the data of a previous systematic review of 2270 cases of CGCLJ, we used the multiple imputation to deal with the missing data. The dependent variable was the recurrence after the first treatment (yes/no). The dichotomic covariates were sex, upper or lower jaw location, size (up to or larger than 4 cm), pain, cortical bone perforation (yes/no), locularity (uni‐/multilocular), tooth displacement (yes/no), treatment type (curettage or enucleation) and root resorption (yes/no). The final logistic model indicated that the tumours associated with tooth displacement, root resorption and treated with curettage had a more significant chance of recurrence. In conclusion, our study suggests that tooth displacement, root resorption and the type of treatment are potentially useful in the future construction of an algorithm for patient's treatment.
Intraosseous xanthoma of the mandible: A multi‐institutional case series with a literature review
Authors: de Arruda José Alcides Almeida , Almeida Tatiana Fernandes Araújo , Abreu Lucas Guimarães , do Amaral Márcio Bruno Figueiredo , Anbinder Ana Lia , Flores René Martínez , Agostini Michelle , Romañach Mário José , Silva Tarcília Aparecida , de Andrade Bruno Augusto Benevenuto , Mesquita Ricardo Alves 
Published: July 2019

AbstractBackgroundThe aim of the present study was to report the clinicopathologic, radiographic and immunohistochemical features of five South American cases of intraosseous xanthomas of the mandible and to compare them to those detected in a literature review.MethodsClinical data were collected from the records of three Oral and Maxillofacial Pathology services in South America and compared with those compiled from a literature review based on a search of three electronic databases (PubMed, Web of Science and Scopus). All cases were evaluated by haematoxylin and eosin staining and immunohistochemistry for CD68 and S‐100.ResultsThe series comprised four females (80%) and one male (20%) with a mean age of 23.3 ± 10.9 years (range: 13‐45 years). In four cases, there was involvement of the posterior region of the mandible (80%). The lesions presented radiographically as unilocular (60%) radiolucencies with punched‐out margin (80%). All cases predominantly consisted of CD68‐positive and S‐100‐negative xanthomatous cells. No recurrences were observed after curettage, with a median follow‐up of 27 months.ConclusionIntraosseous xanthoma of the jaws is a rare benign disorder. We report here five additional cases affecting the mandible, for a total of 36 cases of the jaws reported in the literature. Overall, this lesion has predilection for posterior sites of the mandible of asymptomatic young adults.
Influence of risk factors in the ESC‐EHRA EORP atrial fibrillation ablation long‐term registry
Authors: Trines Serge A. , Stabile Giuseppe , Arbelo Elena , Dagres Nikolaos , Brugada Josep , Kautzner Josef , Pokushalov Evgeny , Maggioni Aldo P. , Laroche Cécile , Anselmino Matteo , Beinart Roy , Traykov Vassil , Blomström‐Lundqvist Carina ,   on behalf of the ESC‐EHRA Atrial Fibrillation Ablation Long‐Term Registry investigators
Published: July 2019

AbstractBackgroundThe influence of risk factors on atrial fibrillation (AF) ablation recurrence is increasingly recognized. We present a sub‐analysis of the European Society of Cardiology‐European Heart Rhythm Association‐European Society of Cardiology AF ablation long‐term registry on the effect of traditional risk factors for AF on postablation recurrence, reablation, and complications using real‐world data.MethodsRisk factors for AF were defined as body mass index ≥27 kg/m², hypertension, chronic obstructive pulmonary disease, diabetes, alcohol ≥2 units/day, sleep apnea, smoking, no/occasional sports activity, moderate/severe mitral or aortic valve disease, any cardiomyopathy, peripheral vascular disease, chronic kidney disease, heart failure, coronary artery disease/infarction, and previous pacemaker/defibrillator implant. Patients were divided in two groups with ≥1 or without risk factors. Primary outcomes were arrhythmia recurrence after blanking period, reablation, and adverse events or death. Differences between the groups and the influence of individual risk factors were analyzed using multivariate Cox regression.ResultsThree thousand sixty nine patients were included; 217 patients were without risk factors. Risk factor patients were older (58.4 vs 54.1 years), more often female (32% vs 19.8%) and had more often persistent AF (27.2% vs 23.5%). In a multivariate analysis, patients without risk factors had a hazard ratio of 0.70 (95% CI 0.49‐0.99) for recurrence compared to risk factor patients. The multivariate hazard ratios for reablation or adverse events/death were not different between the two groups. Hypertension and body mass index were univariate predictors of recurrence.ConclusionsPatients with ≥1 risk factor had a 30% higher risk for arrhythmia recurrence after ablation, but no differences in risk for repeat ablations and adverse events or death.
Inheritance and molecular mapping of restorer‐of‐fertility (Rf) gene in A2 hybrid system in pigeonpea (Cajanus cajan)
Authors: Sharma Pankaj , Singh Inderjit , Sirari Asmita , Khosla Gaurav , Singh Gurjeet , Ludhar Navkiran Kaur , Singh Sarvjeet 
Published: July 2019

AbstractInheritance of fertility restorer gene in pigeonpea was studied using F2 and BC1F1 populations derived from cross AL103A × IC245273. It was found to be controlled by single dominant gene. Out of 228 SSR primer pairs, 33 primer pairs showed parental polymorphism, while four primers were found polymorphic in bulk segregant analysis (BSA). These four primers viz., CcM 1615, CcM 0710, CcM 0765 and CcM 1522 were used for genotyping of F2 population and were found to be placed at 3.1, 5.1, 28.1 and 45.8 cM, respectively. Two of them, CcM 1615 and CcM 0710, evinced clear and unambiguous bands for fertility restoration in F2 population. The Rf gene was mapped on linkage group 6 between the SSR markers CcM 1615 and CcM 0710 with the distances of 3.1 and 5.1 cM, respectively. The accuracy of the CcM 1615 was validated in 18 restorers and six maintainer lines. The marker CcM 1615 amplified in majority of male restorer lines with a selection accuracy of 91.66%.
Trichinella spiralis muscle larvae release extracellular vesicles with immunomodulatory properties
Authors: Kosanović Maja , Cvetković Jelena , Gruden‐Movsesijan Alisa , Vasilev Saša , Svetlana Milanović , Ilić Nataša , Sofronić‐Milosavljević Ljiljana 
Published: July 2019

AbstractAimsExtracellular vesicles (EVs) represent a newly discovered but universal communication tool between cells or organisms. However, few data exist on nematode EVs and none for Trichinella spiralis. Here, we aimed to investigate whether T spiralis muscle larvae produce EVs, whether they carry immunomodulatory proteins and whether they have a role in immunomodulation as a component of excretory‐secretory muscle larvae products (ES L1).Methods and resultsEVs were enriched from conditioned medium of T spiralis muscle larvae. Transmission electron microscopy images showed T spiralis EVs to be 30‐80 nm in size, and Western blot confirmed the presence of two out of three glycoproteins with the immunodominant epitope characteristic for muscle larvae of the genus Trichinella. Using a peripheral blood mononuclear cell (PBMC) stimulation assay, it was shown that these EVs elevated production of IL10 and IL6.ConclusionT spiralis muscle larvae produce EVs. Those EVs carry immunomodulatory proteins and have the capacity independently to induce regulatory responses in the same way as the T spiralis excretory‐secretory muscle larvae products from which they were isolated.
A review of the known unknowns in the early stages of septoria tritici blotch disease of wheat
Authors: Brennan C. J. , Benbow H. R. , Mullins E. , Doohan F. M. 
Published: July 2019

Septoria tritici blotch (STB) disease of wheat is caused by the fungal pathogen Zymoseptoria tritici. It is the most important foliar disease of wheat in western Europe and affects wheat cultivation worldwide. The combination of intensive fungicide usage, a polycyclic asexual life cycle and an active sexual cycle has led to the emergence of fungal strains resistant/tolerant to all the major classes of fungicides used in its control. The hallmark of this disease is a long, symptomless latent phase that precedes the onset of visible symptoms. Understanding the processes that occur during the symptomless phase of infection is paramount in developing alternative strategies for disease control; however, large gaps in our knowledge of the disease remain. The known unknowns of the latent stage of infection can be summarized in three questions. Does the fungus initiate or manipulate host defences to trigger programmed cell death in order to facilitate nutrient acquisition or is the host acting exclusively? Does the fungus feed during both the latent phase and the necrotrophic phase like a true hemibiotroph? Does the long latent phase serve a beneficial function for the fungus or is it simply an artefact of evolution? This review aims to distil observations made during studies that have directly or indirectly contributed to answering these questions and points towards their most likely answers.
Detailed Model of a Thermoelectric Generator Performance
Authors: Buchalik Ryszard , Nowak Iwona , Rogozinski Krzysztof , Nowak Grzegorz 
Published: July 2019

Abstract
The paper deals with mathematical modeling of heat transfer phenomena occurring in a system containing thermoelectric elements. The main focus was on creating a useful computational tool for designing, validating, testing, controlling, and regulating the energy harvesting system with a thermoelectric cell. The model widely described in the literature, assuming a constant temperature level on both sides of the cell, has been modified to take into account the thermal resistance of heat exchangers that are inseparable parts of nearly every device of this kind. The results and conclusions from the solutions of equations forming a formalized record of the proposed method, the assumed approach to modeling, used physical phenomena and sensitivity analysis of the impact of the tested parameters on the system operation was presented. The calculations were made for the data of a selected thermoelectric generating cell available on the market.
Design, Modeling, and Test: The Hydraulic Vibration Energy Recovery System of Speed Bump
Authors: Guo Yan , He Ren 
Published: July 2019

Abstract
This paper designs a hydraulic vibration energy recovery system of speed bump that can recover vehicle vibration energy while decelerating the vehicle. Using hydraulic fluid as the energy recovery medium for deceleration, according to the speed range of vehicles passing through the speed bump, a design scheme for the hydraulic vibration energy recovery device for speed bump with a combination of split generation and continuous generation is proposed. Based on the coupling characteristics of the vehicle-speed bump-hydraulic transducer at different speeds of the vehicle, a joint simulation model was established to study the speed bump power generation module. Based on the simulation results, the hydraulic system operating parameters and component types were determined. Finally, a simulation test was conducted on an improved test-bed to test the power generation capability of the system.
Multiple-Objective Optimization for Solar Concentrator Layout
Authors: Wang Kung-Jeng , Dao Le Duc 
Published: July 2019

Abstract
Solar energy is critical because it does not only sustain global environment but also produce ample power to use. This study addresses solar concentrator layout to maximize the profit for the firm manufacturing the concentrator, while helping an energy user receives as much sunlight as possible. We consider several key design factors of a solar concentrator layout, such as light transmission loss, to make the model more accurate. As for the economic scale of production, some key constraints are considered, such as concentrator thickness and the number of exits, where a sunbeam is delivered to an optical cable for energy transmission. To obtain a high brightness from a good solar concentrator for the user, the concentrator manufacturer requires to increase the complexity of concentrator layout, but suffers from the high manufacturing cost. In this study, we simultaneously address the issues of the optimal solar concentrator layout and trade-off of conflict objectives between the energy user and the concentrator manufacturer. This study proposes a nondominated sorting genetic algorithm for multiple-objective optimization solution. To summarize, the result from this study presents a promising solution both for the light efficiency to supply users and for the profit of the firm on delivering the solar concentrator layout.
Evaporative Wicking Phenomena on Nanotextured Surfaces
Authors: Le Duong Vy , Pham Quang N. , Lee Jonggyu , Zhang Shiwei , Won Yoonjin 
Published: July 2019

AbstractAs modern electronics become miniaturized with high power, thermal management for electronics devices has become significant. This motivates the implementation of new cooling solutions to dissipate high-heat levels from high-performance electronics. Evaporative cooling is one of the most promising approaches for meeting these future thermal demands. Thin-film evaporation promotes heat dissipation through the phase change process with minimal conduction resistance. In this process, it is important to design surface structures and corresponding surface properties that can minimize meniscus thickness, increase liquid–vapor interfacial area, and enhance evaporation performances. In this study, we investigate thin-film evaporation by employing nanotextured copper substrates for varying thermal conditions. The liquid spreading on the nanotextured surfaces is visualized using a high-speed imaging technique to quantify evaporative heat transfer for various surfaces. The permeability is calculated using an enhanced wicking model to estimate the evaporation effect combined with the mass measurements. Then, infrared (IR) thermography is employed to examine two-dimensional temporal temperature profiles of the samples during the evaporative wicking with a given heat flux. The combination of optical time-lapse images, evaporation rate measurements, and temperature profiles will provide a comprehensive understanding of evaporation performances using textured surfaces.
Altered ellipsoid zone reflectivity and deep capillary plexus rarefaction correlate with progression in Best disease
Authors: Romano Francesco , Arrigo Alessandro , Leone Pier Pasquale , Saladino Andrea , Bandello Francesco , Battaglia Parodi Maurizio 
Published: July 2019

AimsTo evaluate the effects of neurovascular damage in patients with the typical vitelliform lesion of Best vitelliform macular dystrophy (BVMD) in the attempt to identify different progression patterns.MethodsProspective, observational case series. Patients in the vitelliform stage of BVMD and healthy controls underwent complete ophthalmological examination on a yearly basis, including best-corrected visual acuity (BCVA), biomicroscopy, optical coherence tomography (OCT) and OCT angiography (OCT-A). 4.5×4.5 mm OCT-A slabs were imported into ImageJ software and their vessel density (VD) was calculated. Similarly, the ellipsoid zone (EZ) was manually outlined and the reflectivity was measured above the vitelliform lesion and in the 500 µm external to it. Retinal pigment epithelium–Bruch’s membrane complex was taken as internal reference.Results34 eyes (24 patients) and 34 matched controls were included in the study. Mean follow-up was of 28.4±5.8 months, with 12 eyes showing signs of stage progression at the end follow-up. The EZ overlying the vitelliform lesion and in the peri-lesional area disclosed a significant reduction in reflectivity when compared with the foveal and para-foveal EZ of controls, respectively. VD resulted meaningfully decreased only at the deep capillary plexus. Of notice, more extensive EZ (reflectivity <0.7) and vascular alterations (VD <0.4) at baseline strongly correlated with worse BCVA and were associated with a more rapid progression at follow-up.ConclusionsBoth EZ reflectivity and VD at deep capillary plexus may prove valuable biomarkers to assess BVMD severity and detect progression. In this view, ‘rapid progressors’ might benefit the most from timely genetic therapies in the future.