bluuebunny/crossref_metadata_2025_split huggingface dataset:
Description of the surgical technique for condylectomy with minimally invasive surgery to treat interdigital helomas on the lesser toes: a Delphi study
Authors: Marti‐Martinez Luis M. , Gracia‐Sánchez Alba , Ferrer‐Torregrosa Javier , Lorca‐Gutierrez Rubén , Garcia‐Campos Jonatan , Sánchez‐Pérez Salvador Pedro 
Published: February 2019

AbstractBackgroundDescriptions of the techniques for condylectomies via minimally invasive surgery (MIS) to treat interdigital helomas of the lesser toes are scarce in the literature. This study aimed to define and describe this surgical technique.MethodsThis observational study was performed using the Delphi method. We collected the anonymous opinions of a multidisciplinary international panel of ten experts by answering a 43‐items questionnaire via e‐mail. Statements with an average score ≥ 3 were included in the next round, as were those in which none of the three statements reached the minimum score of 3 within the same item.ResultsResponse rate: 90%. Three rounds were needed to reach consensus on proposed items. A new statement that combined two statements was proposed in round 3. Eleven recommendations regarding the incision and instruments used to perform this surgical technique were obtained based on the expert consensus.ConclusionsA longitudinal incision to the distal pulp of the toe or an incision to the centre of the plantar aspect of the head of the proximal phalanx should be performed according to the affectation, and a Beaver 64 scalpel blade, a blunt elevator and a Shannon‐Isham burr are the most acceptable tools for this kind of surgery.
Hemodynamically self-corrected ΔADC analysis in idiopathic normal pressure hydrocephalus
Authors: Takatsuji-Nagaso Marina , Miyati Tosiaki , Ohno Naoki , Mase Mitsuhito , Kasai Harumasa , Shibamoto Yuta , Kobayashi Satoshi , Gabata Toshifumi , Kitagawa Kiyohide 
Published: February 2019

Objective:
To clarify the cause of higher water fluctuation of the brain in idiopathic normal pressure hydrocephalus (iNPH), we assessed change in hemodynamic-independent apparent diffusion coefficient during the cardiac cycle (ΔADC) in iNPH.

Methods:
Electrocardiographically synchronized single-shot diffusion echo-planer imaging (b = 0, 500, and 1000 s/mm2) was performed in healthy volunteers, atrophic ventricular dilation group, and iNPH group, respectively. The ΔADC (b = 0 and 1000 s/mm2) and maximum ADC (b = 0 and 500 s/mm2) in the cardiac cycles were measured at the frontal white matter in the brain. Then, self-corrected ΔADC was obtained from the ΔADC divided by the maximum ADC (ADCpeak: perfusion-related diffusion) to correct the blood flow effect.

Results:
The ΔADC after correction was significantly higher in the iNPH group than in the other two groups. However, there was no significant difference in ADCpeak values among the groups.

Conclusion:
Self-corrected ΔADC in iNPH increased because of changes in the biomechanical properties of the brain. Self-corrected ΔADC analysis makes it possible to obtain information on hemodynamically independent water fluctuation as well as perfusion in iNPH.

Advances in knowledge:
Analysis self-corrected ΔADC provides simultaneously information on biomechanical properties, perfusion, and water fluctuation in iNPH.
Visceral Debranching for the Treatment of Thoracoabdominal Aortic Aneurysms
Authors: Damrauer Scott , Fairman Ron 
Published: February 2019

Abstract
Based on a Presentation at the 2013 VEITH Symposium, November 19–23, 2013 (New York, NY, USA)
Surgical repair of thoracoabdominal aortic aneurysms (TAAA) is associated with significant morbidity and mortality. Hybrid approaches that involve visceral debranching and aortic endografting allow for an alternative approach in certain high-risk patients. In most circumstances the visceral vessels can be bypassed in a retrograde manner from the iliac arteries via a midline laparotomy, and the aortic aneurysm subsequently excluded with standard aortic endografts. These procedures avoid the extensive two-cavity exposure, aortic cross-clamping, and mechanical circulatory support that comprise open TAAA repair, and offer the theoretical advantage of being less invasive. Despite this, outcomes have been mixed with reported perioperative mortality rates of 0% and 34% and permanent paraplegia rates of 0% to 13% in most major series. The reported outcomes, as well as the variation between centers, highlight the importance of patient selection in undertaking hybrid repair. In practice, the best outcomes are achieved in patients who have high-risk anatomy, rather than high-risk comorbidities.
Arterial Stiffness Alterations and Inflammatory Response Following Endovascular Aortic Repair
Authors: Moulakakis Konstantinos , Mylonas Spyridon , Kakisis John , Kadoglou Nikolaos , Papadakis Ioannis , Sfyroeras George , Antonopoulos Constantine , Mantas George , Ikonomidis Ignatios , Liapis Christos 
Published: February 2019

Abstract
Based on a Presentation at the 2013 VEITH Symposium, November 19–23, 2013 (New York, NY, USA)
Endovascular abdominal aortic aneurysm repair (EVAR) and thoracic aortic aneurysm repair (TEVAR) have been widely incorporated into clinical practice. However, changes in arterial stiffness and post-implantation syndrome after aortic endografting remain important issues under investigation. The aneurysm sac wall motion after successful EVAR and TEVAR reflects complex interactions between all the components of the excluded aneurysm, including true compliance of the aneurysm wall itself, intra-aneurysm sac pressure, remodeling of the thrombus, and mechanical characteristics of the endograft. Experimental and clinical studies have shown that aortic endografting results in increased arterial stiffness in animal models. It can be assumed that the alterations of aortic mechanical properties can have a direct impact on heart output. The long-term impact of these mechanical changes on cardiovascular outcomes and the potential effects of different endografts on hemodynamics are important issues under investigation. Post-implantation syndrome (PIS) is a systemic inflammatory response frequently observed after endovascular treatment of aortic pathologies. The main features of PIS include fever, leukocytosis, elevated C-reactive protein levels, and coagulation disturbances. Endograft design appears to influence this inflammatory response following aortic endografting; woven polyester endografts have been shown to be associated with greater inflammatory response compared to PTFE stent grafts. The purpose of this paper is to review the literature to elucidate arterial stiffness alterations and inflammatory response after EVAR and TEVAR and the impact of endograft design on aortic stiffness and the post-inflammatory response.
Persistent Buttock Claudication after Endovascular Abdominal Aortic Aneurysm Repair
Authors: Robaldo Alessandro , Pagliari Stefano , Piaggio Filippo , Colotto Patrizio 
Published: February 2019

AbstractWe describe the successful surgical treatment of a 71-year-old man affected by right buttock claudication after a right internal iliac artery (IIA) coil embolization as an adjunct to endovascular iliac artery aneurysm repair. Computed tomography angiography revealed extensive aortoiliac calcifications and thrombus in the vessel walls. Despite patency of the contralateral IIA and preservation of right distal collateral flow through ipsilateral hypogastric branches, the symptom was persistent and disabling. The high-risk patient underwent an “open” repair of the infrarenal abdominal aneurysm with removal of the entire stent-graft and concomitant revascularization of the right IIA. Post-operative recovery was uneventful, and the patient remained asymptomatic during a 30-month follow-up. This case underscores the importance of considering all potential solutions, including open surgery, to preserve pelvic inflow after aortoiliac stent grafting, particularly for high-risk patients with vulnerable plaque and higher risk of thrombus embolization.
Single-stage Endovascular Treatment of a Penetrating Aortic Ulcer with a Concomitant “Isolated” Iliac Aneurysm
Authors: Hu Haidi , Guo Jianming , Bai Hualong , Dardik Alan 
Published: February 2019

AbstractPenetrating aortic ulcer (PAU) is an acute aortic syndrome that can proceed to life-threatening aortic dissection or even aortic rupture. Isolated iliac aneurysms are relatively rare and often asymptomatic due to their deep pelvic location but are frequently associated with high mortality with rupture. We report a case of a 68-year-old man with a symptomatic penetrating ulcer in the descending aorta and an asymptomatic right iliac aneurysm involving the common and internal iliac arteries. The patient was successfully treated by endovascular repair in a single-stage manner using stent grafts in the descending aorta and right common iliac artery after coil embolization of the right internal iliac artery. Follow-up imaging showed complete resolution of the PAU and exclusion of the right iliac aneurysm without endoleak. Aggressive endovascular treatment for a symptomatic PAU with an asymptomatic isolated iliac aneurysm is feasible and allows complete treatment of vascular pathology at a single time.
Optimization of a Whole-Stalk Operating System after Sugarcane Base Cutting
Authors: Xie Luxin , Wang Jun , Cheng Shaoming , Hu Jinbing 
Published: February 2019

Abstract. Leaf stripping and top breaking are the key procedures in whole-stalk sugarcane harvesting. In this study, a whole-stalk operating system after sugarcane base cutting was developed and tested to improve the leafy trash cleaning performance and adaptability of a whole-stalk harvester. A leaf shredding procedure was proposed before leaf stripping, and an anti-float top breaking device was developed for breaking cane tops. The rotational speeds of the leaf shredding (RL), leaf stripping (RS), and top breaking (RT) rollers were regarded as experimental factors, and the leafy trash content (including leaves, leaf sheaths, and tops in this study), top breaking rate, abrasion rate, and non-fracture rate of the middle or bottom parts were selected as indices. Central composite design combined with response surface methodology and comprehensive evaluation method were employed to conduct experiments and explore the interaction effects of factors on indices. The optimal operating parameters were nonlinearly optimized and determined to be RL of 512.9 rpm, RS of 418.8 rpm, and RT of 307.0 rpm. Under these conditions, the predicted values of leafy trash content, top breaking rate, abrasion rate, and non-fracture rate were 4.98%, 88.39%, 5.19%, and 96.21%, respectively. Verification experiments indicated that the observed values were in agreement with the predicted values. Results suggested that the leaf shredding device and anti-float top breaking device developed in this study were effective for improving the leafy trash cleaning performance and adaptability of the whole-stalk operating system, and there was a good potential for performance improvement of whole-stalk sugarcane harvesters. Keywords: Central composite design, Leaf shredding, Leaf stripping, Response surface methodology, Top breaking, Whole-stalk harvester.
LAPOR HENDI : JEMBATAN PENGADUAN YANG SETENGAH HATI
Authors: Dzakiyati Fiki , Nugroho Rosihan Widi , Warsono Hadi 
Published: February 2019

Lapor Hendi adalah layanan publik berbasis online untuk menyampaikan pengaduan, menyampaikan aspirasi dan berkomunikasi langsung dengan Pemkot Semarang. Inovasi ini menjadi sarana perbaikan layanan publik melalui peran aktif masyarakat dalam melakukan pengawasan. Penelitian ini bertujuan untuk mengevaluasi pengelolaan pelayanan pengaduan Lapor Hendi serta faktor penghambat dalam layanan Lapor Hendi. Menggunakan metode deskriptif kualitatif dengan studi kasus, pengambilan data melalui studi pustaka dan wawancara. Penelitian ini menggunakan teori William Dunn, 6 faktor dalam melalkukan evaluasi : efektivitas, efisiensi, kecukupan, perataan, responsivitas dan ketepatan serta faktor penghambat dalam pelaksanaan kebijakan. Dalam kajian ditemukan ada 2 faktor utama yang menghambat Lapor Hendi yaitu Sumbar Daya Manusia (SDM) dan Teknologi. Untuk meningkatkan penyelesaikan pengaduan diperlukan SOP sebagai panduan layanan, bukti bahwa pengaduan telah diselesaikan dan kontak penanggung jawab jika masyarakat melakukan konfirmasi terhadap pengaduan.
PENGARUH KETIDAKAMANAN KERJA, KETERLIBATAN KARYAWAN DAN DUKUNGAN ORGANISASI TERHADAP KINERJA KARYAWAN DENGAN KOMITMEN ORGANISASIONAL SEBAGAI VARIABEL INTERVENING PADA KARYAWAN BAGIAN PRODUKSI BULU MATA PALSU PT. COSMOPROF INDOKARYA DI KABUPATEN BANJARNEGARA
Authors: Pawestri Tyasih Sukma , Pradhanawati Ari 
Published: February 2019

The performance of employees the production of eyelashes PT. Cosmoprof Indokarya shown at an average of the results of each employee in the years 2013-2015 tends to fluctuate. The target of production is set by the company is 1.56 million pairs of eyelashes, but only about 1.4 million pairs of eyelashes can be produced. To deal with the problem is to determine what factors are causing the employee's performance did not reach the target. The high levels of stress and perceived environmental changes employees will create a sense of insecurity that can affect the performance degradation. Lack of organizational support received by employees will affect their performance. When employees are participating in the work and do not have a strong desire to survive in the organization will decrease the performance of the employee. This is also shown by the employee turnover rate of 20% by year. This study aims to identify and analyze the effects of job insecurity, employee engagement, organizational support and organizational commitment to employee performance and organizational commitment partially as an intervening variable. Researchers ask 10 (ten) hypothesis in this study. This type of research is a quantitative research study classification based on objective being explanatory, where statistics were used to analyze the sample data and results will be generalizable to populations where samples were taken. The population in this study were all employees of the production PT.Cosmoprof Indokarya as many as 941 employees and the number of samples 91 employees. Data were analyzed using SEM-PLS and use data analysis tools SmartPLS 3.0. The data analyzed comes from distributing questionnaires to employees. Results of testing the coefficient of SEM analysis showed that: (H1) is rejected; (H2) is received; (H3) is received; (H4) is received; (H5) is received; (H6) was rejected; (H7) is received; (H8) is rejected; (H9) was rejected; (H10) is rejected. The results of the study explains there are some weak indicators of each variable job insecurity, employee engagement, organizational support, organizational commitment, and employee performance. It is recommended that companies to review, evaluation, and give motivation and training on employees in order to improve their capabilities.
Rapid susceptibility testing of multi-drug resistant Escherichia coli and Klebsiella by glucose metabolization monitoring
Authors: Kittel Maximilian , Findeisen Peter , Ghebremedhin Beniam , Miethke Thomas , Grundt Alexander , Ahmad-Nejad Parviz , Neumaier Michael 
Published: February 2019

Abstract

Background
The increasing number of multi-drug resistant (MDR) bacteria provides enormous challenges for choosing an appropriate antibiotic therapy in the early phase of sepsis. While bacterial identification has been greatly accelerated by the introduction of matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS), the antibiotic susceptibility testing (AST) remains time-consuming. Here, we present a rapid susceptibility testing method for testing Gram-negative bacteria, exemplarily validated for Escherichia coli and Klebsiella spp.

Methods
Gram-negative isolates (E. coli and Klebsiella spp.) were either taken as single colonies from agar plates (n=136) or directly extracted and identified from positive blood cultures (n=42) using MALDI-TOF MS. Bacteria were incubated in glucose-supplemented Luria broths (LBs) each containing one antibiotic (ceftazidime, piperacillin, imipenem and ciprofloxacin), routinely used to classify Gram-negative bacteria in Germany. To determine susceptibility the dynamics of glucose utilization in bacterial suspensions were quantitatively measured in the presence or absence of antibiotics designated liquid-AST (L-AST).

Results
The L-AST can be run on clinical-chemistry analyzers and integrated into laboratory routines. It yields critical resistance information within 90–150 min downstream of a MS-based identification. The results showed a high concordance with routine susceptibility testing, with less than 1% very major errors (VME) and 3.51% major errors (ME) for 178 assessed isolates. Analysis of turnaround time (TAT) for 42 clinical samples indicated that L-AST results could be obtained 34 h earlier than the routine results.

Conclusions
As exemplified for E. coli and Klebsiella spp., L-AST provides substantial acceleration of susceptibility testing following MALDI-TOF MS identification. The assay is a simple and low-cost method that can be integrated into clinical laboratory to allow for 24/7 AST. This approach could improve antibiotic therapy.
The effect of DOAC-Stop on lupus anticoagulant testing in plasma samples of venous thromboembolism patients receiving direct oral anticoagulants
Authors: Ząbczyk Michał , Kopytek Magdalena , Natorska Joanna , Undas Anetta 
Published: February 2019

Abstract

Background
Direct oral anticoagulants (DOACs) cause false positive lupus anticoagulant (LA) results. We assessed the impact of DOAC-Stop, reversing in vitro effects of DOACs, on LA testing in anticoagulated patients.

Methods
We assessed 75 venous thromboembolism patients aged 44.5±14.6 years. Blood samples were collected 2–28 h since intake of DOACs, including 50 patients on rivaroxaban, 20 on dabigatran and five on apixaban. LA testing was performed at baseline and after DOAC-Stop treatment. Positive LA was defined as the normalized (patient/standard plasma clotting time) LA screening and screening (LA1)/confirmation (LA2) ratios exceeding 1.2.

Results
LA diluted Russell’s viper venom time (dRVVT) normalized screening test revealed abnormal results in 73 (97.3%) and activated partial thromboplastin time (APTT)-LA in 49 (65.3%) patients. In six (8%) patients, antiphospholipid syndrome (APS) was diagnosed. dRVVT LA1/LA2 was abnormal in 35 (50.7%) patients taking DOACs. The APTT ratio was normal in all studied subjects. DOAC-Stop completely removed dabigatran and reduced by 98% rivaroxaban and by 92.3% apixaban concentrations (all p<0.05). After DOAC-Stop screening dRVVT remained prolonged in 34 (49.3%) patients (p<0.001), while dRVVT LA1/LA2 was abnormal in six (8.7%) subjects, with no association with DOAC concentrations at baseline and after DOAC-Stop. The APTT-LA screening test remained prolonged in five (7.2%) patients, while the APTT LA1/LA2 ratio was normal in those subjects. DOAC-Stop did not influence LA testing in APS patients.

Conclusions
Application of DOAC-Stop effectively reduced plasma DOAC concentrations leading to appropriate dRVVT results in up to 97% of VTE patients.
A Multilevel Examination of Entrepreneurial Orientation and Corporate Entrepreneurship: the Joint Impact of Unit-Level Social Capital and Firm-Level Transformational Leadership
Authors: Chang Yi-Ying , Liu Yi Ping , Chang Che-Yuan 
Published: February 2019

Abstract
We examine the relationship between unit-level entrepreneurial orientation (EO) and unit-level corporate entrepreneurship (CE), which has been typically neglected in entrepreneurship research. Building on the conservation of resource theory (COR), we argue that the relationship between unit-level EO and unit-level CE will be stronger when unit-level social capital is higher. Further, we posit that unit-level social capital becomes more effective when firm-level leaders are viewed as less (and not more) transformational by unit members. Data were collected from 186 managers, 372 employees, and 62 senior managers from 93 units of 31 firms. We find that unit-level EO is positively related to unit-level CE and this relationship strengthens when unit-level social capital is high. This moderating effect of social capital is itself moderated by firm-level transformational leadership, and strengthens as firm-level transformational leadership behaviors decrease (supporting “dark side” views of transformational leadership). Implications of our findings for organizational entrepreneurship research and practice are discussed.
Cellulolytic activity of brown-rot Antrodia sinuosa at the initial stage of cellulose degradation
Authors: Sugano Junko , Linnakoski Riikka , Huhtinen Seppo , Pappinen Ari , Niemelä Pekka , Asiegbu Fred O. 
Published: February 2019

Abstract
The initial stage of cellulose degradation has been studied via in vitro assays of fungi isolated from rotten wood in a boreal forest. Among the 37 isolates, Antrodia sinuosa appeared to be an effective cellulose degrader and was selected for studying the initial degradation process. In the liquid cultivation with carboxymethylcellulose (CMC), the increase of the mycelial dry weight coincided with the pH decrease of the culture medium from pH 5.7 to 3.9, between the 3rd and 6th cultivation day. At the same time, the cellulolytic activity increased; the CMCase activity increased sharply and the reducing sugars reached their maximum concentration in the culture medium. It seems that the decreasing pH enables the cellulose degradation by A. sinuosa at an early stage of the process. The results of this study may be useful for a more efficient industrial application of biomass by means of brown-rot fungi.
Nm23-H1 inhibits hypoxia induced epithelial-mesenchymal transition and stemness in non-small cell lung cancer cells
Authors: Wu Cun-en , Zhuang Yu-wen , Zhou Jin-yong , Liu Shen-lin , Zou Xi , Wu Jian , Wang Rui-ping , Shu Peng 
Published: February 2019

Abstract
The Nm23 gene has been acknowledged to play a crucial role in lung cancer metastasis inhibitory cascades controlled by multiple factors. Low expression or allelic deletion of nm23-H1 is strongly linked to widespread metastasis and poor differentiation of non-small cell lung cancer (NSCLC). In this study, nm23-H1 was down regulated in epithelial-mesenchymal transition (EMT) and stemness enhancement under cobalt chloride (CoCl2)-induced hypoxia in NSCLC cells. Moreover, knocking down of nm23-H1 by shRNA apparently promoted hypoxia induced EMT and stemness, which was entirely suppressed via over expression of nm23-H1. Mechanistically, the Wnt/β-catenin signaling pathway was found to participate in the nm23-H1-mediated process. Besides, XAV939 prohibited cell EMT and stemness which could be impaired by knocking down of nm23-H1, while stable transfection of nm23-H1 attenuated hypoxia phonotype induced by lithium chloride (LiCl). Generally, our experiment provided evidence that nm23-H1 can reverse hypoxia induced EMT and stemness through the inhibition of the Wnt/β-catenin pathway, which may furnish a deeper perspective into the better treatment or prognosis for NSCLC.