bluuebunny/crossref_metadata_2025_split huggingface dataset:
Results of the prospective EORTC Children Leukemia Group study 58081 in precursor B‐ and T‐cell acute lymphoblastic leukemia
Authors: Domenech Carine , Kicinski Michal , De Moerloose Barbara , Piette Caroline , Chahla Wadih A. , Kornreich Laure , Pasquet Marlène , Uyttebroeck Anne , Theron Alexandre , Poirée Marilyne , Arfeuille Chloé , Bakkus Marleen , Grardel Nathalie , Paillard Catherine , Freycon Claire , Millot Frédéric , Simon Pauline , Philippet Pierre , Pluchart Claire , Suciu Stefan , Rohrlich Pierre , Ferster Alina , Bertrand Yves , Cavé Hélène ,   for the Children's Leukemia Group (CLG) of the European Organization for Research and Treatment of Cancer (EORTC)
Published: November 2024

AbstractHere, we report the results of the prospective cohort study EORTC‐CLG 58081 and compare them to the control arm of the randomized phase 3 trial EORTC‐CLG 58951, on which treatment recommendations were built. In both studies, patients aged 1–18 years with BCR::ABL1 negative acute lymphoblastic leukemia of the B‐lineage (B‐ALL) or T‐lineage (T‐ALL) were treated using a BFM backbone without cranial irradiation. Similarly to the control arm of 58951, prednisolone (PRED) 60 mg/m2/day was used for induction therapy, but a few modifications were made. Dexamethasone (DXM) was used in average‐risk 2 (AR2) T‐ALL and B‐ALL during induction, 10 and 6 mg/m2/day, respectively. Leucovorin rescue was delayed to 42 h instead of 36 h after initiation of high‐dose methotrexate, and a postconsolidation MRD time point was added to stratify patients. Between 2011 and 2017, 835 patients were prospectively enrolled in the 58081 study. Overall, the 5‐year event‐free survival (EFS) was 84.8% versus 83.6% (hazard ratio [HR], 0.96 [95% confidence interval [CI]: 0.76–1.21]) for 58081 versus 58951 considered as a control group, respectively, 84.3% versus 84.9% (HR, 1.06 [99% CI: 0.75–1.49]) in B‐ALL but 87.3% versus 76.6% (HR, 0.59 [99% CI: 0.28–1.24]) in T‐ALL. The comparison between the two studies regarding EFS differed by risk group (p = 0.012). The HR was 2.15 (99% CI: 0.67–6.85) for very low‐risk but 0.34 (99% CI: 0.13–0.89) for AR2. The particularly favorable results observed in the T‐ALLs and AR2 subgroups suggest the benefit of using DXM in specific patient groups and highlight the importance of risk stratification.
Tele‐Medical Nutrition Therapy to Promote Healthy Eating and Nutrition Adherence of Chronic Patients in the COVID‐19 Pandemic: A Pragmatically Before‐After Trial
Authors: Norouzi Somaye , Majd Fateme Arefi , Rostami Somaye , Mirzaee Moghadameh , Sistani Samane , Ahmadian Leila 
Published: November 2024

ABSTRACTBackground and AimsPatients find it difficult, during the pandemic, to receive appropriate nutrition services because of the limited access to health services. This study assessed the effectiveness of a tele‐consulting nutrition intervention on the nutrition adherence of patients with diabetes and hypertension.MethodsA tele‐medical nutrition therapy (MNT) intervention was conducted as a one‐group before‐after trial. The estimated sample size was 314. Of these, 183 patients were selected from Hefdah‐e‐Shahrivar and 131 from Farabi Hospital. Patients were asked to complete an adapted version of the nutrition adherence self‐reported instrument to compare nutrition adherence when they received face‐to‐face therapy versus tele MNT.ResultsIn total, 166 completed all phases of the study. The results showed that the nutrition adherence score significantly increased compared to before the intervention. Hedges's g effect size also confirmed the high efficacy of telenutrition therapy. The magnitude of differences was within a high range (effect size 3.76 [CI: 3.40–4.12]).ConclusionsThe present findings showed that providing teleconsulting nutrition services to diabetic and hypertensive patients can positively affect their nutrition adherence. Telenutrition to promote a healthy diet can contribute to effectively controlling diseases in chronic patients during/after the pandemic with no gaps or failures.Trial RegistrationThis study was a tele‐nutrition intervention. In this study, we provided consultation on regular food consumption and did not order any chemical substances or nutritional supplements. Furthermore, we did not perform any treatment or invasive intervention, we assumed that a registration number was unnecessary, so we did not apply for clinical trial registration.
Weighted Vest Combined With Vibrotactile Stimulations Decrease the Sympathetic Activity: A Repeated Measures Study
Authors: Maula Mohamad Izzur , Ammarullah Muhammad Imam , Nugwita Chandra Maulana , Faisal Muhammad Sultan , Afif Ilham Yustar , Husaini Farhan Ali , Lamura M. Danny Pratama , Jamari Jamari , Winarni Tri Indah 
Published: November 2024

ABSTRACTBackground and AimsMental and neurological disorders are a growing global concern, further intensified by the COVID‐19 pandemic. Stress management techniques, such as deep pressure therapy, have gained attention, with weighted vests commonly used for anxiety relief. However, there is limited scientific evidence supporting their efficacy. This study aimed to rigorously assess the effectiveness of a weighted vest incorporating vibrotactile stimulation in reducing anxiety by measuring physiological indicators—pulse rate and skin conductance (SC)—as well as subjective comfort ratings.MethodsA total of 30 final‐semester college students participated in the study. Participants wore a vibrotactile‐weighted vest, and both pulse rate and skin conductance (SC) were measured to gauge anxiety levels. Additionally, participants rated their comfort using a Comfort Rating Scale (CRS). Changes in pulse rate and SC were statistically analyzed, and effect sizes (Cohen's d) were calculated to assess the magnitude of the intervention's impact.ResultsThe weighted vest with vibrotactile stimulation resulted in a significant reduction in both pulse rate (dpulse = 0.23–0.62) and SC (dsc = 0.32–0.66), indicating a small to medium effect size in anxiety reduction. Subjective evaluations of the vest using the CRS revealed low scores on discomfort‐related items, with participants rating unfavorable statements between 1.5/10 and 4.6/10, suggesting overall comfort during use.ConclusionThis study provides compelling evidence that vibrotactile‐weighted vests effectively reduce anxiety, as indicated by both physiological measures and subjective comfort ratings. The findings support the potential of this intervention as a formal therapeutic tool for stress and anxiety reduction. Further research may explore long‐term effects and broader applications in clinical settings.
Comparing the Efficacy of Empirical Anti‐Infective Therapy and Follow‐Up Observation for Newly Diagnosed Pulmonary Ground‐Glass Nodules With Suspected Inflammatory Etiology: A Multicenter Prospective Observational Study Protocol
Authors: Feng Wenhong , He Tao , Zhang Yuanqiang , Mu Yunfei , Pu Yang , Liu Ying , Ouyang Zhangning , Song Hangao , Zhong Yiming , Lu Hong , Zhou Yanglin , Zou Ping , Yang Gang , Tian Honggang , Jin Jianglin , Liang Gaoyu , Yang Lin , Zhang Laian , Liu Yangjun , Dai Wei , Qing Haomiao , Zhang Jingyu , Shi Qiuling , Li Qiang , Yang Ding , Zhang Rui , Wei Xing 
Published: November 2024

ABSTRACTBackground and AimsThe optimal management strategy for newly diagnosed pulmonary ground‐glass nodules (GGNs) with suspected inflammatory etiology remains controversial in clinical practice. Empirical anti‐inflammatory therapy is commonly used, but its efficacy compared with that of follow‐up observation lacks high‐quality evidence. Therefore, this study aims to compare the effectiveness of empirical anti‐infective therapy and follow‐up observation for pulmonary GGNs in real‐world settings.MethodsThis study intends to include 254 participants with newly discovered pulmonary ground‐glass opacities (GGOs) suspected to be related to inflammation but without current radiographic features suggestive of malignancy. Antibiotics will be recommended when the doctor considers the GGOs may be infection‐related. Upon enrollment, all participants will be assessed with the Self‐Rating Anxiety Scale (SAS) and divided into either the intervention or observation group. A repeat CT scan and SAS assessment will be conducted with all participants after 1 month ( ± 2 weeks) following the initial discovery of the GGOs. The primary outcome is the participants' response rate at the first follow‐up CT. The secondary outcome is the GGO response rate and total scores of SAS at 1 month after enrollment. A non‐inferiority test will be conducted to compare the outcomes between the two groups.DiscussionTo date, the efficacy and necessity of using antibiotics for GGOs suspected to be inflammatory upon primary CT screening remain controversial. This protocol describes the rationale and methodology to address this unmet clinical need using real‐world data, aiming to bridge the gap between clinical guidelines and real‐world practice.Trial Registration: ChiCTR2200056975.
Validating the Effect of Topography and Geology on Rainfall–Runoff in Mountainous Catchments Using the Improved HYdrologic CYcle Model
Authors: Inaoka Jun , Kosugi Ken'ichirou , Masaoka Naoya 
Published: November 2024

ABSTRACTRainfall–runoff characteristics of mountainous catchments are affected by many factors, such as topography and geology. Traditionally, the effects of geology on rainfall–runoff characteristics have been explained using geology, but the differences in runoff characteristics within the same geological settings have not been examined. These differences can be expressed as differences between the hydrological model parameters. However, the effects of geology on the model calculations have not yet been clarified. Thus, this study aims to clarify the effects of topography and geology on model calculations using an improved HYdrologic CYcle (HYCY) model that considers bedrock infiltration. Runoff observations were conducted for approximately 3 years in 19 catchments at 2 sites located in sedimentary rock and granite mountains. Rainfall was recorded at each site. The observed hydrographs were used to optimise the parameters for each catchment using the least‐squares method. The relationship between parameter m and the soil layer storage was calculated using the optimised parameters, representing the percentage of the area contributing to runoff. Furthermore, these results were compared with observational analysis results. The improved HYCY model accurately represented all 19 runoffs. When the total precipitation in 1 event exceeded 200 mm, parameter m became ~1 and ~0.3–0.4 in sedimentary rock and granitic catchments, respectively, which shows the effect of geology. The effects of topography on the parameters were exhibited in Kc and Kb, which calculated the storm flow from the channels and baseflow hydrographs, respectively. However, the parameter distributions exhibited geological differences, namely in parameter Kh, Kb and m. The parameter Kh calculates the overland flow hydrograph. This implies that geological differences affect the probability of the overland flow generation rate and the recession hydrographs of the overland flow and baseflow.
Maternal illnesses during pregnancy and the risk of childhood cancer: A medical‐record based analysis (UKCCS)
Authors: Bonaventure Audrey , Simpson Jill , Kane Eleanor , Roman Eve 
Published: November 2024

AbstractOften relying on mother's recollections of past events, the possible relationship between maternal illness in pregnancy and risk of malignancy in their offspring has long been a focus of research. Free from recall bias, this study of childhood cancer (0–14 years) examined these associations using data abstracted from mothers' primary‐care (1623 cases, 2521 controls) and obstetric (2721 cases, 5169 controls) records. Maternal infections and other illnesses in pregnancy were examined for any possible associations with childhood leukaemia, lymphoma, CNS or embryonal tumours using pooled information from the two medical record sources (2885 cases and 5499 controls), accounting for potential confounders. Maternal anaemia was associated with childhood acute myeloid leukaemia (AML) (odds ratio, OR = 2.07, 95%CI [1.40–3.08]). Anaemia during pregnancy was also recorded more frequently in the notes of mothers of children with medulloblastoma, retinoblastoma and embryonal rhabdomyosarcoma: ORs 2.36 [1.36–4.11], 1.83 [1.01–3.33] and 2.91 [1.64–5.16] respectively. Other associations included urinary tract infections (UTIs) and non‐Hodgkin lymphoma (NHL); preeclampsia and NHL; and polyhydramnios with both AML and NHL. No evidence was found to suggest that influenza during pregnancy impacted on childhood leukaemia risk. In conclusion, our findings are supportive of an association between maternal anaemia in pregnancy and childhood AML, and maternal anaemia and embryonal tumours; underscoring the need for further research exploring the potential causes and roles of iron and vitamin deficiencies. Due to small numbers and lack of corroborative evidence, the associations observed for UTIs, preeclampsia, and polyhydramnios must be treated cautiously.
Disseminated intravascular coagulation is an underestimated but fatal adverse event associated with blinatumomab therapy: A pharmacovigilance analysis of FAERS
Authors: Song Zhiqiang , Wang Yang , Zhang Dongliang , Wang Tao , Liu Na , Gao Lei , Wang Libing , Yang Jianmin 
Published: November 2024

AbstractHematologic adverse events (AEs) are common and serious toxicities in patients with hematologic malignancies undergoing blinatumomab therapy. However, restrictive selection criteria in pivotal clinical trials can lead to an underestimation of rare but fatal toxicities. In this study, we systematically analyzed hematologic AEs associated with blinatumomab using the Food and Drug Administration Adverse Event Reporting System (FAERS) from October 2014 to December 2023. Disproportionate analysis was performed to identify overreported AEs, with a reporting odds ratio (ROR), and a lower bound of the 95% confidence interval (ROR025) exceeding one considered significant. Additionally, adjusted mortality rates and risk ratios (RR) of the top 10 reported hematologic AEs were calculated using a logistic regression model. Among 4745 blinatumomab‐related cases, 418 (8.81%) involved hematologic AEs. We identified 22 significantly overreporting hematologic AEs compared to the full database, with myelosuppression (n = 39 [9.33%], ROR025 = 8.04), disseminated intravascular coagulation (DIC, n = 31 [7.42%], ROR025 = 15.14), and bone marrow failure (n = 14 [3.35%], ROR025 = 3.41) notably underestimated in clinical trials. DIC resulted in a substantial mortality rate of 45.16%. Finally, DIC was found to be independently associated with death in a multivariable logistic regression analysis (RR = 2.47 [95% CI: 1.11–3.83]). These findings could aid clinicians in the early detection of these rarely reported but fatal hematologic AEs, thereby reducing the risk of severe toxicities in blinatumomab recipients.
COMPUTER TO PLATES – A REALITY
Authors: Larson Larry G. 
Published: November 2024

AbstractComputer‐to‐press plates represent a concept which was advanced many years ago, and which is viewed by many within the field as the final step in the development of an all‐electronic prepress system. Experts within the industry mostly agree on the trends, they generally agree on the ultimate results, but they often disagree on the current status of the technology or on a plan to get to the final result.
It's not just about skills: Adopting a motivation‐informed approach to instruction with adolescents
Authors: Conradi Smith Kristin , Jang Bong Gee , Ostot Tori J. 
Published: November 2024

AbstractAn issue devoted to foundational skills and adolescents might center the cognitive skills and practices most needed to accelerate learning. While an understanding of these—whether multisyllabic decoding, fostering comprehension through discussion, or argumentative writing—is important, in this article, we advocate for the importance of attending to principles of motivation. After defining motivation within the context of adolescent literacy instruction, we summarize representative research on the topic. We then present four guiding principles for teachers, each accompanied by practical examples for classroom application.
Choice versus no choice: Practical considerations for increasing choices
Authors: Kim Ji Young , Morris Cody , Ellsworth Megan E. , Liu Xiaoyuan , Seacord Nicole F. 
Published: November 2024

AbstractChoice involves engaging in a selection response when multiple options are concurrently available. Choices can be incorporated into many components of behavior‐analytic treatment such as providing clients with a choice between multiple items, activities, or tasks. We reviewed the main characteristics of 38 behavior‐analytic articles that compared choice and no‐choice conditions. We coded the experimental arrangements of choice and no‐choice conditions and analyzed potential factors affecting preferences for choice and no choice. The findings suggest that the sizing of alternatives from which to choose, the timing of choice opportunities, and the timing of the delivery of the chosen option varied across the studies. Furthermore, preferences for choice shifted with differential reinforcement history and response effort manipulations of choice or no choice. The findings suggest that individual variables should be considered when providing choices, but more research is needed.
The Role of PI3K/AKT/HIF‐1α Pathway in the Effect of Nano‐TiO2 on Lactate Production in TM4 Cells
Authors: Chang Hongmei , Zhao Siqi , Lei Yuzhu , Hu Yunhua , Yan Yizhong , Song Guanling 
Published: November 2024

ABSTRACTTitanium dioxide nanoparticles (nano‐TiO2) can cause a reduction in sperm counts, and lactate production in Sertoli cells plays a key role in spermatogenesis. The aim of this study was to evaluate the effect of nano‐TiO2 on lactate production in mouse Sertoli cell line (TM4 cells) and to investigate whether the effect is mediated through the PI3K/AKT/HIF‐1α pathway. After TM4 cells were treated with different concentrations of nano‐TiO2 for 48 h, cell viability, contents of glucose and lactate, and the expression levels of GLUT3 and key enzymes (HK1, HK2, PFKM, ENO1, LDH) during lactate production were detected. PI3K/AKT/HIF‐1α pathway proteins were measured. In addition, PI3K agonist (IGF‐1) was added to explore whether nano‐TiO2 regulates HIF‐1α through PI3K/AKT pathway, thereby affecting the production of lactate in TM4 cells. The results showed that nano‐TiO2 significantly inhibited TM4 cell viability, increased glucose content, decreased lactate content, and downregulated the expression levels of GLUT3 and key enzymes during lactate production. Meanwhile, nano‐TiO2 decreased the expression of PI3K/AKT pathway phosphorylated proteins and HIF‐1α, and IGF attenuated this effect of nano‐TiO2. Collectively, nano‐TiO2 downregulated the expression level of proteins and enzymes related to lactate production in TM4 cells by inhibiting PI3K/AKT/HIF‐1α pathway, resulting in the decrease of lactate production in TM4 cells.
Cholesterol Depletion Activate Hepatic Stellate Cells Mediated Through SREBP‐2 Signaling
Authors: Vijayan Nivya , Perumal Madan Kumar 
Published: November 2024

ABSTRACTLiver fibrosis is one of the leading cause of death worldwide. In liver, hepatic stellate cells are the primary cell type that gets activated during fibrosis. LX‐2 cells are human‐derived hepatic stellate cell lines typically employed for studying liver fibrosis mechanisms and screening anti‐fibrotic lead molecules. Although LX‐2 cells are partially activated in culture conditions, numerous stimuli including TGF‐β, H2O2, hypoxia, LPS were reported to activate LX‐2 cells. In this study, for the first time, the effect of cholesterol depletion on LX‐2 cells was studied. Under cholesterol‐depleted conditions, the mRNA and protein expression of HSC activation markers (α‐SMA, GFAP) were significantly increased. Also, the expression of SREBP‐2, HMGCR were significantly upregulated in response to cholesterol depletion. Treatment with fatostatin, a reported SREBP inhibitor abolished nuclear SREBP‐1 and SREBP‐2 expression and regulated the SREBP signaling. Transmission electron microscopic imaging showed distinct ultrastructural changes in response to cholesterol depletion. Furthermore, cholesterol depletion did not affect the cell‐cycle profile of LX‐2 cells compared with untreated while fatostatin treatment induced G2 cell‐cycle arrest. Overall, cholesterol depletion activated LX‐2 cells mediated by SREBP‐2 signaling and therefore could be further employed as stimuli for LX‐2 activation and screening lead molecules targeting SREBPs.
Outcomes of transitioning from mandatory to elective research at a dental school in Southern California
Authors: Kwon So Ran , Oyoyo Udochukwu , Estey Mark 
Published: November 2024

AbstractObjectivesThe purpose of this study was to assess the impact of a curricular change from mandatory to elective research on the student research outcomes at a Southern California Dental School over ten years. Additionally, the perception of dental students and faculty toward research in dental education was assessed.MethodsA survey was distributed to determine the perception towards research in dental education, motivation and barriers for pursuing research and the possibility participants would pursue research—even if the school did not mandate it. The survey was distributed to a total of 507 dental students and 121 full‐time faculty.ResultsBoth dental students (80.6%) and faculty (91.4%) agreed that learning about research is important in dental education. Both cohorts generally agreed that research experience enhances dental training, supports the scientific basis of dental treatment methods, and correlates with clinical ability. The majority of students (77.0%) disagreed with mandating research while faculty (77.6%) believed that it should be mandated. Lack of time was the single most stated barrier for participating in research. The overall trend during the transition from mandatory to elective research showed that initially there was a stark drop in students and faculty participation and projects being carried out. However, with deliberate planning, research outcomes steadily increased.ConclusionsWe conclude that dental students and faculty have a positive perspective on the importance of research in dental education and actively engage in research and mentoring activities when provided with a supportive and encouraging environment. This participation occurs regardless of whether research is mandated or elective.