bluuebunny/crossref_metadata_2025_split huggingface dataset:
Badiuzzaman Said Nursi's Approach to Effective Da'wah Management: The Role of Eye Contact, Facial Expressions and Body Gestures in Information Delivery
Authors: Noor Muaz Mohd , Suyurno S. Salahudin , Sairi Faridah Mohd 
Published: December 2024

Effective communication information is essential today. In the field of da'wah management, the mastery and skills of non-verbal communication by the da’i, such as eye contact, facial expressions, and body language management, can enhance the effective delivery of da’wah messages. In the 21st century, among the successful da’i is Badiuzzaman Said Nursi, whose approach integrates both verbal and non-verbal communication techniques to ensure information reaches its intended audience effectively. This study focuses on the three elements of non-verbal communication contained in Badiuzzaman Said Nursi's kenesik communication, and their role in managing information flow within da’wah. Three elements are eye contact, facial expressions, and body language. The study employed a qualitative approach, utilizing document analysis and content analysis to examine Said Nursi’s writings and da’wah strategies. The results reveal that Badiuzzaman Said Nursi’s effective da’wah management through non-verbal communication significantly contributed to the global acceptance of his message, demonstrating that managing non-verbal cues enhances message clarity and audience engagement. These findings provide valuable insights for preachers in both traditional and contemporary settings, emphasizing the importance of synchronizing verbal and non-verbal communication for effective da’wah management.
Depression, Anxiety, Stress and Its Association with Coping Strategies among Malaysian University Students
Authors: Abdul Halim Bushra , Fuzi Siti Fairus , Jama Siti Ramizah , Zainudin Siti Nursyahira , Jusoh Nordianah , Zahidi Nurul Emyza , Wan Hassan Wan Hartini 
Published: December 2024

Malaysia is one of the countries transitioning from the pandemic phase to an endemic phase of Covid-19. The spread of Covid-19 had a significant impact on university students, affecting their mental health just as it did for many others. This study investigates depression, anxiety, and stress symptom levels among Malaysian university students and the coping strategies used to prevent or reduce these psychological distress symptoms. A web-based questionnaire was developed using Google Forms to collect data from students who were selected non-randomly from three public universities and one from a private university in Malaysia. Patient Health Questionnaire-9 (PHQ-9), Generalized Anxiety Disorder-7 (GAD-7), and Perceived Stress Scales-10 (PSS-10) were used for measuring depression, anxiety, and stress respectively. The coping strategies were measured using five strategies: seeking social support for emotional reasons, seeking social support for instrumental reasons, acceptance, mental disengagement, and humanitarian. The study findings indicated that 60.7% had depression symptoms, 30.4% had anxiety symptoms, and 86.3% had stress symptoms at moderate-to-severe levels. Acceptance was the most preferred coping strategy among the students while seeking social support for instrumental reasons was the least preferred coping strategy. Students with severe depression levels used mental disengagement coping strategies more than those with mild symptoms. Mental disengagement coping strategy was associated with severe anxiety symptoms compared to mild and minimal symptoms. Seeking social support for emotional reasons was also associated with moderate anxiety symptoms compared to mild anxiety symptoms.
Assessment of Ketamine’s Influence on In Vitro Angiogenesis
Authors: Takaishi Kazumi , Takata Marina , Nishikawa Mika , Kitahata Hiroshi , Kawahito Shinji 
Published: December 2024

Objective
Angiogenesis is associated with angiogenic therapy and wound healing processes. It is important for anesthesiologists to understand the effects of perioperative and long-term use of anesthetics on angiogenesis. This study aimed to determine the effects of ketamine on in vitro angiogenesis: the proliferation of human umbilical vein endothelial cells (HUVEC) and normal human diploid fibroblasts (NHDF), HUVEC migration, and in vitro capillary tube formation in cocultured HUVEC and NHDF.

Methods
The effects of ketamine at concentrations of 1, 10, and 50 µM on the proliferation of HUVEC and NHDF for 48 hours were determined by using a water-soluble tetrazolium salt reagent. Quantitation of migration for 22 hours was achieved by measuring the fluorescence of migrating HUVEC exposed to ketamine using an angiogenesis system. The effects of ketamine on capillary tube formation with or without vascular endothelial growth factor (VEGF) were investigated in cocultured HUVEC and NHDF incubated for 3 and 10 days.

Results
Ketamine did not show any enhancing or suppressive effects on the in vitro proliferation of HUVEC and NHDF, HUVEC migration, or capillary tube formation in cocultured HUVEC and NHDF for either 3 or 10 days in the presence or absence of VEGF.

Conclusion
Ketamine had no effects on in vitro angiogenesis using cultured HUVEC and NHDF. Ketamine can potentially be used as an anesthetic agent with no influence on angiogenesis.
A IMPORTÂNCIA DA GOVERNANÇA DE TECNOLOGIA DA INFORMAÇÃO E COMUNICAÇÃO NO DESEMPENHO ORGANIZACIONAL DO PODER JUDICIÁRIO DO ESTADO DO AMAZONAS
Authors: Lima Raysa Freitas de , Palheta Raphael Ribeiro 
Published: December 2024

O tema deste artigo aborda o desempenho organizacional da tecnologia da informação e comunicação no Poder judiciário do Estado do Amazonas, nesse sentido, o objetivo é analisar seu impacto no desempenho da organização. Por meio de pesquisa qualitativa, utilizando questionários aplicados aos membros da Governança de TIC, a metodologia utilizada visou compreender o impacto da governança de TIC na forma de questionário dividido em partes correspondentes aos objetivos traçados, foram avaliadas as políticas, estratégias e estruturas organizacionais, além dos indicadores de eficiência e eficácia. O questionário foi encaminhado para os membros da governança por meio do uso da ferramenta do Word e encaminhado com a utilização de aplicativo de mensagem para coleta de dados, que foram analisados utilizando a técnica de análise de conteúdo. Os resultados apontam que a Governança de TIC contribui significativamente para a melhoria dos processos internos, aumento da eficiência operacional e aprimoramento da qualidade dos serviços prestados.
IMPLEMANTATION OF THE LARAVEL FRAMEWORK IN THE FURNITURE SALES INFORMATION SYSTEM CASE STUDY CV. KUALITA JAYA
Authors: Haqqi Ahmad Difauddin 
Published: December 2024

Kualita Jaya menjual jasa pembuatan furniture interior dan eksterior. CV Kualita Jaya menyediakan pembuatan eksterior interior furniture dengan bahan kayu, aluminium, stainless besi maupun kombinasi material aluminium frame diayam dengan rotan sintetis dan kayu jati. Pada saat ini, CV Kualita Jaya belum memiliki sebuah sistem informasi yang mendukung untuk kebutuhan pemasaran dan pengelolaan data laporan penjualan dan pembelian. Dengan adanya sebuah sistem informasi yang terintregasi, maka diharapkan penjualan CV Kualita Jaya dapat berkembang dan laporan jumlah penjualan pembelian dapat memberikan gambaran umum keuangan bisnis. Dengan belum adanya sistem informasi yang mewadahi maka penelitian ini bertujuan untuk memberikan sistem informasi penjualan pembelian dan laporan berbasis web. Dalam membuat sistem informasi penjualan web, Framework merupakan sebuah kerangka kerja yang digunakan untuk membantu web developer dalam pembuatan sebuah sistem informasi. Dengan menggunakan Framework maka penulisan kode akan menjadi lebih mudah, rapi, dan lebih terstruktur. Adapun Framework yang digunakan dalam adalah Framework Laravel. Implementasi sistem informasi dalam penelitian ini menggunakan PHP, database MySQL, HTML, CSS dan Laravel sebagai Framework.Kata kunci : Web, Framework, Laravel, Sistem Informasi
Generation of primary feline chimeric antigen receptor T cells
Authors: Cockey James R. , Zhou Gavin M. , Kulp Emily N. , Urbina Christian A. , Kerkenpaß Christina , Leifer Cynthia A. 
Published: December 2024

Abstract

OBJECTIVE
The purpose of this study was to develop procedures to engineer feline chimeric antigen receptor (CAR) T cells.

METHODS
6 healthy cats were used in this study. Blood was collected, and CD3+ primary T cells were enriched by magnetic activated cell sorting, expanded, and used to generate CAR T cells.

RESULTS
Phorbol myristate acetate plus ionomycin and concanavalin A induced similar early proliferation of CD3-enriched feline CD4+ and CD8+ T cells but phorbol myristate acetate plus ionomycin induced greater expansion over 12 days. Chimeric antigen receptor T cells were engineered by transduction with an FIV-based lentiviral system to express a human CD19 CAR. Feline CD19 CAR T cells demonstrated specific cytotoxicity against human CD19+ target cells. Conditions were developed to polarize the T cells to THelper subsets.

CONCLUSIONS
We generated functional and specific primary feline CAR T cells and demonstrated conditions to polarize the cells, which may be therapeutically advantageous for CAR T-cell use in a variety of disease contexts.

CLINICAL RELEVANCE
CAR T therapy has been used with great success for human hematologic malignancies and is under development for use in canines. Our study is the first demonstration of functional feline CAR T cells and describes the procedures for their engineering. These findings lay the foundation for future development of CAR T therapy for multiple feline diseases.
Bovine Lung Peptides after Trypsinolysis Reveal Anti-Exudative Activity
Authors: Ishimov U. J. , Gafurova N. , Asrorov A. M. , Wali A. , Mukhamedov N. , Olimjonov S. O. , Vypova N. , Khamidov S. , Abdirahimova S. Sh. , Ziyavitdinov J. F. 
Published: December 2024

Abstract
Enzymatic hydrolysates of proteins isolated from cow lungs are used as anti-inflammatory agents for the growth and regeneration of new tissues. Hydrolysates were observed to inhibit the production of free radicals in cells and have a high anti-exudative activity even in low doses. In this study, we established the anti-exudative activity of peptides of protein hydrolysates isolated from bovine lungs. The anti-exudative activity of the peptides sum was compared with acetylsalicylic acid (ASA) and prednisolone, and the dynamics of inflammation were studied by tumour formation using carrageenan and formalin. Between 1 h and 24 h after administration of the drug, the effect of the peptides sum showed a significantly better indicator than the rest of the means. In general, the anti-exudative activity of the peptides sum was 2–3 times higher than the rest of the preparations. Biochemical indicators of prednisolone and peptides sum in two doses of 10−6 μg/kg and 10−4 μg/kg were studied. As a result of the study, it was found that the peptides sum at 10−6 μg/kg dose enhanced alanine aminotransferase (ALT) activity by 17.1% compared to those resulting from prednisolone treatment. In C-reactive protein (CRP) and antistreptolysin O (ASO) indicators, 10−4 μg/kg dose showed high activity. The sum of isolated peptides reduced ALT and ASO levels. This study provides additional support for preparing anti-inflammatory means from the peptides sum isolated from bovine lungs.
The cyclic vector of realization of cultural memory in the novel "Chagin" by Evgeny Vodolazkin
Authors: Bezrukov Andrey Nikolaevich 
Published: December 2024

Evgeny Vodolazkin has firmly established himself in the latest Russian prose as a master of the realization of artistic intrigue. His novels are a vivid confirmation of this. The writer, in addition to forming a very dense intriguing plot, adding a figurative series, manifesting a point of view, deliberately uses the technique of artistic collision, but in an admittedly realistic way. For Evgeny Vodolazkin, the course of novel events is not only a literal combination of situational episodes, it is also a carefully thought-out dialogue with the reader. The subject of the research in the article is the deciphering of the theme of memory on the example of E.G. Vodolazkin's novel "Chagin". The object of study correlates with the main issue of the text, which builds a narrative, a figurative series, a genre structure. The purpose of the work is a parametric analysis of the manifestation of cultural memory in the specified text. The assessment of the imaginative thinking of the main character, Isidor Chagin, is not excluded in the study, since memory cannot be considered separately from the feeling and perception of reality by the character. The methodological basis of the work is focused on the comparative principles of text evaluation, conceptual verification of the work, taking into account the systematization of receptive connotations. In the novel "Chagin", the main character is going through a crisis state – he cannot forget what he has read, seen, and experienced. Memory is syncretically soldered to the existence of the hero as such, it ontologically sets the metaphysics of the character's existence. The scientific novelty of the study lies in the fact that the novel has not yet been practically studied within the framework of this category, there is no proper assessment of the topic in the critical-analytical type mode. The materials can be useful practically in verifying the style, manner of writing, and artistic thinking of Evgeny Vodolazkin. The conclusions of the work are focused on the fact that memory in the novel "Chagin" is a formula of irreversibility. But the actions and deeds of the hero are in many ways a demonstration of multiplicity. Although Vodolazkin's writing style and poetics do not gravitate towards postmodernism, the influence of modern trends is clearly evident in this work. The plot of the novel is not accidental, the figure of the main character is composed in a special way, but the context itself, clearly expanding, has a multiplicity of excuses. Cultural memory is cyclically oriented, for Evgeny Vodolazkin it is an impulse to destabilize meanings, because it is an ontological task of artistic creation.
Use of ionized plasma jet therapy in the treatment of xanthelasma palpebrarum
Authors: Thobde Mallika , Borkar Milind , Oke Manjiri Abhijit , Dodeja Ajay 
Published: December 2024

Objectives:
To evaluate the safety and efficacy of ionized plasma therapy for the treatment of xanthelasma palpebrarum.

Material and Methods:
A total of 35 patients were enrolled for the study. Patients were screened as per the predefined inclusion and exclusion criteria. The patients were treated with ionized plasma jet therapy (IPJT) plasma machines. Pre- and post-sizes of the xanthelasma lesions were noted along with the side effects, and the patients were followed up for a period of 90 days.

Results:
The complete resolution of the xanthelasma lesion was observed in 28 out of 35 patients, with two patients requiring two sessions, five patients developing hypopigmentation, and 1 patient having hyperpigmentation as a side effect, which was resolved after 4 weeks.

Conclusions:
Based on the results, ionized plasma therapy for xanthelasma palpebrarum can be recommended as a safe and effective option.
Efektivitas Teknik Self-Instruction Untuk Meningkatkan Kepercayaan Diri Pada Santri
Authors: Putri Navion Febranti , Khasanah Zakiyah 
Published: December 2024

Penelitian ini bertujuan untuk mengetahui sejauh mana keefektifan teknik self instruction untuk meningkatkan kepercayaan diri pada santri Pondok Pesantren Mambaus Sholihin 2 Blitar. Pelaksanaan kegiatan dilakukan melalui pemberian konseling individu dengan mendukung adanya perubahan kepercayaan diri santri yang rendah menjadi kepercayaan diri yang lebih tinggi dengan ditandai yaitu cara berfikir yang lebih positif, berani mengambil keputusan dan optimis dalam menjalankan kewajiban. Dalam penelitian ini, metode eksperimen subjek tunggal diterapkan dalam bentuk single subject research (SSR) dalam desain A-B-A. Pada kondisi baseline 1 (A1) dilakukan sebanyak 3 kali pertemuan dengan mean skor 136, pada kondisi intervensi (B) sebanyak 4 kali pertemuan dengan mean skor 172 dan pada fase baseline 2 (A2) dilakukan 3 kali dengan mean skor 199. Pemberian teknik self-instruction terbukti mampu untuk meningkatkan kepercayaan diri santri. Dari uji N-Gain Score didapatkan skor 0,52 atau 52%, sehinggaÂ dapat disimpulkan bahwa teknik self instruction cukup efektif untuk meningkatkan kepercayaan diri padaÂ santri.
Simples “demoras” vs. “inactividad administrativa”: Notas para el estudio conceptual de los plazos máximos de los procedimientos administrativos y su incumplimiento
Authors: Saavedra Bazán Ernesto José 
Published: December 2024

El autor aborda las notas principales para un estudio conceptual del ‘plazo legal’ y el ‘plazo razonable’ en los procedimientos administrativos de evaluación previa, a efectos de asociarlos con los conceptos de simples ‘demoras’ e ‘inactividad administrativa’. Se identifica una serie de oportunidades para mejoras legislativas a la normativa administrativa general nacional, así como para un cambio de paradigmas sobre el procedimiento administrativo mismo.
Effectiveness of the Ayah ASI Group Education on the Self-efficacy of Pregnant Women in Providing Exclusive Breastfeeding
Authors: Saima Putri Siregar  , Evi Karota Bukit  , Farida Linda Sari Siregar  
Published: December 2024

The success of exclusive breastfeeding is related to self-efficacy, the mother's belief in her ability to provide exclusive breastfeeding is getting better, and the support ofher husband plays an important role in increasing the mother's self-efficacy. The purpose of this study was to analyze the effectiveness of Ayah ASI group education on pregnant women's self-efficacy in breastfeeding plans. The method used was a quasi experimental non-equivalent with control group pretest-posttest intervention. The sample consisted of 27 respondents in the intervention group at the clinic of Neri midwife clinic and 27 respondents in the control group at Pratama Niar clinic with consecutive sampling technique. The intervention was given in theform of “Ayah ASI” education for three weeks.
Analisis Pengendalian Mutu Kemasan Produk Mi Instan X dengan Metode Six Sigma di PT. Y
Authors: Kusumaningrum Julia , Haris Helmi , Fanani Muhammad Zainal , Jumiono Aji , Amalia Lia 
Published: December 2024

PT. Y merupakan perusahaan yang bergerak di bidang industri makanan yang memproduksi mi instan yang dikemas dengan kemasan plastik dan ditambah dengan bumbu sesuai jenis rasa. Selama proses produksi berjalan, ditemukan adanya produk yang cacat atau kerusakan pada kemasannya. Tujuan dari penelitian ini adalah untuk mengetahui jenis cacat/ defect, melakukan analisis faktor-faktor penyebab cacat/defect dari produk yang sering terjadi dan menyusun upaya perbaikan dengan menggunakan metode Six Sigma yang terdiri atas tahap Define, Measure, Analyze, Improve dan Control (DMAIC). Hasil penelitian menunjukkan bahwa perusahaan Y memiliki nilai sigma sebesar 4,06. Melalui hasil analisis yang dilakukan diketahui bahwa terdapat 3 cacat/defect yang dominan terjadi pada pengemasan produk mi instan merk X yaitu kemasan berlubang tertusuk mi sebesar 39,464%, mi tertekan seal kemasan/gencet mi sebesar 24,138% dan kemasan meletus sebesar 16,475%. Faktor penyebab kerusakan kemasan produk berasal dari faktor manusia, metode, bahan dan mesin. Usulan perbaikan yang direkomendasikan yaitu pembentukan tim Quality Improvement, adanya penambahan Instruksi Kerja (IK) untuk pengecekan tekanan conveyor busa di mesin packing dan IK untuk penyortiran mi, mencari bahan kemas dan busa penekan yang lebih tepat, maintenance dan perbaikan untuk mesin slitter, perbaikan thermocontrol dan pengadaan singkron untuk conveyor busa penekan dan conveyor mi.
Glikosida Steviol Sebagai Pemanis Rendah Kalori Berbasis Ekstrak Stevia
Authors: Sembiring Bagem Br , Mardiah Mardiah , Fanani Muhammad Zainal 
Published: December 2024

Gula sebagai salah satu bahan aditif yang dapat menambah rasa manis atau nikmat pada makanan ataupun minuman. Kebutuhan terhadap gula cukup tinggi karena merupakan kebutuhan sehar-hari. Untuk memenuhi permintaan, pemerintah melakukan impor dan ada beberapa perusahaan menciptakan gula buatan tetapi dapat berdampak negatif terhadap kesehatan manusia. Daun stevia mengandung glikosida steviol pemberi rasa manis rendah kalori dan dapat diperoleh melalui proses ekstraksi. Stevia dapat diolah menjadi berbagai jenis bentuk produk, seperti simplisia,ekstrak kering, tablet, teh. Selain sebagai pemanis, daun stevia bermanfaat untuk kesehatan. Mutu simplisia dipengaruhi oleh proses pengeringan dan mutu ekstrak dipengaruhi oleh mutu simplisia sebagai bahan baku ekstraksi. Kualitas ekstrak berhubungan dengan senyawa metabolit sekunder dipengaruhi oleh jenis pelarut dan konsentrasi pelarut, lama ekstraksi, suhu, kehalusan bahan, perbandingan bahan dengan pelarut dan metode ekstraksi. Jenis pelarut yang efektif untuk mengekstrak stevioside adalah air dan etanol. Ekstrak stevia rasanya lebih manis dibandngkan gula tebu teapi memiliki rasa sedikit pahit.
Integrasi Moderasi Beragama Pada Pengembangan Kurikulum Merdeka Belajar Pendidikan Agama Islam Dalam Membentuk Penguatan Profil Pelajar Pancasila
Authors: Abdul Azis Achmad 
Published: December 2024

Tujuan penelitian ini untuk menganalisis moderasi beragama ke dalam pengembangan kurikulum merdeka belajar pendidikan agama Islam untuk memperkuat profil pelajar pancasila dengan menganalisis penerapan, internalisasi dan dampaknya. Metode penelitian ini menggunakan pendekatan deskriptif kualitatif dengan metode penelitian studi pustaka (library research) melalui tinjauan literatur dan analisis konseptual. Pengumpulan data diperoleh dengan meninjau literatur yang relevan termasuk buku, dokumen, artikel dan kebijakan pendidikan, serta meninjau literatur online. Data yang terkumpul akan dianalisis secara cermat untuk memperoleh pemahaman komprehensif mengenai integrasi moderasi beragama dalam pengembangan kurikulum merdeka belajar pendidikan agama Islam untuk memperkuat profil pelajar pancasila dan implikasi praktis dari ketiga konsep terintegrasi tersebut dalam konteks pendidikan saat ini. Hasil penelitian ini menunjukkan bahwa integrasikan moderasi beragama ke dalam pengembangan kurikulum merdeka belajar pendidikan agama Islam untuk memperkuat profil pelajar pancasila, dapat membantu meningkatkan kesadaran dikalangan peserta didik tentang bahayanya intoleransi, ekstremisme, dan radikalisme. Selain itu, moderasi beragama dalam pengembangan kurikulum merdeka belajar pendidikan agama Islam dalam memperkuat profil pelajar pancasila memberikan dampak positif bagi peserta didik dengan meningkatkan pemahaman peserta didik tentang moderasi beragama dan Pancasila pada mata pelajaran pendidikan agama Islam, diantaranya melalui toleransi, kepekaan terhadap perbedaan, pengembangan karakter, kebijaksanaan individu, pemikiran kritis dan kreativitas, serta penanaman sikap moderat dalam kehidupan sehari-hari melalui pendekatan holistik dan pembelajaran kolaboratif serta pemecahan masalah melalui proyek Kontekstual.