bluuebunny/crossref_metadata_2025_split huggingface dataset:
Predicting ionizing radiation exposure using biochemically-inspired genomic machine learning
Authors: Zhao Jonathan Z.L. , Mucaki Eliseos J. , Rogan Peter K. 
Published: June 2018

Background: Gene signatures derived from transcriptomic data using machine learning methods have shown promise for biodosimetry testing. These signatures may not be sufficiently robust for large scale testing, as their performance has not been adequately validated on external, independent datasets. The present study develops human and murine signatures with biochemically-inspired machine learning that are strictly validated using k-fold and traditional approaches. Methods: Gene Expression Omnibus (GEO) datasets of exposed human and murine lymphocytes were preprocessed via nearest neighbor imputation and expression of genes implicated in the literature to be responsive to radiation exposure (n=998) were then ranked by Minimum Redundancy Maximum Relevance (mRMR). Optimal signatures were derived by backward, complete, and forward sequential feature selection using Support Vector Machines (SVM), and validated using k-fold or traditional validation on independent datasets. Results: The best human signatures we derived exhibit k-fold validation accuracies of up to 98% (DDB2, PRKDC, TPP2, PTPRE, and GADD45A) when validated over 209 samples and traditional validation accuracies of up to 92% (DDB2, CD8A, TALDO1, PCNA, EIF4G2, LCN2, CDKN1A, PRKCH, ENO1, and PPM1D) when validated over 85 samples. Some human signatures are specific enough to differentiate between chemotherapy and radiotherapy. Certain multi-class murine signatures have sufficient granularity in dose estimation to inform eligibility for cytokine therapy (assuming these signatures could be translated to humans). We compiled a list of the most frequently appearing genes in the top 20 human and mouse signatures. More frequently appearing genes among an ensemble of signatures may indicate greater impact of these genes on the performance of individual signatures. Several genes in the signatures we derived are present in previously proposed signatures. Conclusions: Gene signatures for ionizing radiation exposure derived by machine learning have low error rates in externally validated, independent datasets, and exhibit high specificity and granularity for dose estimation.
Revisão de ferramentas para avaliação ergonômica
Authors: Pagnoncelli Laperuta Dalila Giovana , Adamczuk Oliveira Gilson , Ribas Pessa Sergio Luiz , Poglia da Luz Roger 
Published: June 2018

O propósito deste artigo é analisar os métodos/ferramentas de avaliação ergonômica por meio da identificação e definição dos métodos, incidência de publicações e análise de especialistas. Utilizando ajuste das séries históricas por ajuste de séries temporais, obteve-se uma tendência linear ascendente em publicações para 23 dos 24 métodos identificados neste estudo, sendo os mais frequentes: NIOSH, fanger, NASA-TLX, OWAS, REBA e RULA. O método NIOSH, o mais incidente em publicações, foi muito bem avaliado pelo grupo, tendo sido utilizado por todos os especialistas consultados. Os métodos NASA-TLX (3º) e REBA (5º) também foram bem avaliados e utilizados pelos ergonomistas, ficando acima da média de avaliação e uso. Embora a consulta aos especialistas gere resultados semelhantes à investigação quantitativa, sua maior contribuição é de caráter qualitativo, cujas percepções fundamentam a análise crítica dos métodos de avaliação ergonômica sob a luz da literatura. Concluiu-se que, em complemento a essas informações, é preciso considerar a particularidade da tarefa e a experiência do profissional de ergonomia no processo de escolha do método de avaliação ergonômica. Por fim, identificou-se muitos métodos semelhantes, derivados ou associados entre si, sendo necessário estudar o processo de análise e avaliação ergonômica em busca de perspectivas para uma abordagem de avaliação ergonômica unificada (estudos futuros).
MAH 15887: Animal Husbandry and Animal Paleography
Authors: Cavigneaux Antoine , Clevenstine Emmert 
Published: June 2018

AbstractThe cuneiform collection of the Musée d’art et d’histoire of Geneva, Switzerland, includes a document that dates to the 30th year of King Rīm-Sîn of Larsa and displays the features of the reports described 50 years ago by F.R. Kraus in Staatliche Viehhaltung im altbabylonischen Lande Larsa. Interesting features of the tablet are its use of both sexagesimal and centesimal notation, its attestation of one more variation on Rīm-Sîn’s post-Isin year formula, and its illustration of a paleographic issue that has exercised Assyriologists for almost 100 years.
The Reliability of Technical and Tactical Tagging Analysis Conducted by a Semi-Automatic VTS In Soccer
Authors: Beato Marco , Jamil Mikael , Devereux Gavin 
Published: June 2018

AbstractThe Video Tracking multiple cameras system (VTS) is a technology that records two-dimensional position data (x and y) at high sampling rates (over 25 Hz). The VTS is of great interest because it can record external load variables as well as collect technical and tactical parameters. Performance analysis is mainly focused on physical demands, yet less attention has been afforded to technical and tactical factors. Digital.Stadium® VTS is a performance analysis device widely used at national and international levels (i.e. Italian Serie A, Euro 2016) and the reliability evaluation of its technical tagging analysis (e.g. shots, passes, assists, set pieces) could be paramount for its application at elite level competitions, as well as in research studies. Two professional soccer teams, with 30 male players (age 23 ± 5 years, body mass 78.3 ± 6.9 kg, body height 1.81 ± 0.06 m), were monitored in the 2016 season during a friendly match and data analysis was performed immediately after the game ended. This process was then replicated a week later (4 operators conducted the data analysis in each week). This study reports a near perfect relationship between Match and its Replication. R2 coefficients (relationships between Match and Replication) were highly significant for each of the technical variables considered (p < 0.001). In particular, a high score of interclass correlation and a small coefficient of variation were reported. This study reports meaningless differences between Match and its Replication (intra-day reliability). We concluded that the semi-automatic process behind the Digital.Stadium® VTS was more than capable of recording technical tagging data accurately.
The esophageal manometry with gas-perfused catheters
Authors: Höhne Sven , Arndt Martin , Hesse Viola 
Published: June 2018

Abstract

Background
The well-established methods for esophageal manometry have some disadvantages: the-water-perfused catheters needs calibration by gravity and measuring in supine position, and the solid-state catheters are very expensive. Manometry using gas-perfused catheters is a suitable alternative. There have been only a few publications about this.

Objectives and methods
The results for esophageal manometry in 1700 patients were retrospectively analyzed based on the clinical reports and the manometry data. The gas-perfusion manometry was critically assessed.

Results
The mean age was 54 years. The indications for esophageal manometry were GER symptoms in 58.5% (pathological DeMeester score in 41.8%), dysphagia in 12.4%, and already known achalasia in 8.9%. Motility disorders could be found in 40% of the patients with GER symptoms (51% of the patients with pathological DeMeester score), and in 88% of achalasia patients. The resting LES pressure was 8.9±5.94 mmHg with GER symptoms, 16.4±12.79 mmHg without GER symptoms, and 26.8±14.03 mmHg with achalasia. The relaxation LES pressure was 20.0±10.93 mmHg in achalasia patients, and 8.3±5.77 mmHg in the others.
The gas-perfusion manometry was well tolerated by all patients without any serious complications.

Discussion
Manometry using gas-perfused catheters is an easy to handle and inexpensive method to investigate the esophageal motility. The suitability of gas perfusion with helium for esophageal manometry depends on physical and technical requirements, such as a constant gas flow, a dead space in the transducer, and the catheter being as small as possible. In consideration of this, the detection of the pressure changing in swallowing acts is excellent. The measured LES pressures are generally lower than with other methods like with water-perfused or solid-state catheters, possibly because of the higher compliance in a gas-filled surrounding. The normal values in gas-perfusion manometry are comparable but not identical with the values of other manometric methods.
Criminal court ordered assessments in France and Canada
Authors: Prat Sebastien S , Praud Noemie , Barney Lauren 
Published: June 2018

In this Letter to the Editor, we aim to compare the Canadian and the French forensic psychiatry system. Comparing both systems is interesting because France is considered as one of the oldest modern justice systems, and many of the forensic concept are inherited from it or its European neighbours. On the other hand, Canada is one of the countries where the modern forensic psychiatry is born, implementing the actual scientific concepts of criminology. Although the overall goal of the Justicer system and Forensic Psychiatry is the same in both countries, the theoritecal and practical differences help each professional to reflect on their own practice in their jurisdiction.
Testing and Evaluating the Effect of Adding Fibers and Nanomaterials on Improving the Performance Properties of Thin Surface Asphalt
Authors: Tanzadeh Javad , Otadi Ameneh 
Published: June 2018

Abstract
Thin surface treatments are used to improve the functional condition but not the structural condition of a roadway. In this study of superior adhesion, flexibility, and durability values, an optimum combination of quick emulsions of cationic modified with styrene butadiene rubber polymer and hybrid nanomaterial (by 4 wt. % nanosilica and 3 wt. % nanoclay) additives and asphalt emulsion, together with consuming 0.4 wt.% polyethylene fibers that can be defined as a reinforced thin surface treatment, or fiber-reinforced microsurfacing, was used. An appropriate mix design was selected according to the results of a cohesion test, wet track test, and load wheel test. It was found that the effect of nanomaterials on the increase of the stability of the mixture and accelerating setting for a quick crossing of traffic flow was achieved by far more than adding residual asphalt and fiber to the mixture. Since cationic emulsifiers act as antistripping agents after breaking of the emulsion, nanosilica also causes an 8 % increase in adhesive asphalt emulsions. Also, the results show that nanosilica caused a 5 % increase in the cohesion of the asphalt emulsion. The nanoclay, on the other hand, was found to cause a 12 % increase in the resistance to surface abrasion. However, the application of the nanosilica and fiber causes acceleration of the emulsion break. Furthermore, considering the role of fibers in crack prevention, the results obtained from the low-temperature flexural creep test show an increase in the flexural tensile strength value by 17 %, which is used to evaluate the cracking resistance, and a 27 % reduction in the value of displacements, as well as resistance to rutting.
Physical Model Test and Evaluation for the Tunnel Stability Influenced by Magnitude and Path of Loading
Authors: Hao Xian-Jie , Yuan Liang , Xue Jun-Hua , Wang Shao-Hua , Ren Bo , Zhang Xiang-Yang , Li Yu-Lin 
Published: June 2018

Abstract
The stability of an underground tunnel is closely related to its stress path. Here, a total of twelve load levels with three load paths are designed to analyze the influence of magnitude and path of stress on the stability of an underground tunnel from the perspective of tunnel displacement characteristics, stress distribution, and crack propagation by physical model testing and numerical simulation. The results show that the cracks are generated from the corner of the sidewall first by the vertical maximum principal stress; the larger the initial loading, the higher the initial crack position in the sidewalls of the tunnel, and the tendency of the cracking to converge to the arch foot is also more obvious. As the applied pressure increases, the average length and depth of cracking of the sidewall, the radial strain, and the circumferential strain all undergo an exponential increase; the average length grows faster than the depth, and the growth in radial strain is faster than that of the circumferential strain. When tunnels with different loading paths are subjected to the same applied pressure, and if the load rate is low because of progressive damage, it leads to damage at greater depths, but the displacements are relatively small. On the contrary, when the load rate is rapid, under the effect of a certain dynamic load, the damage is more severe, and the displacements are larger; but, because the load is borne by the entire model, the depth of the damage is relatively small. It is important to note that the effect of the stress path applies only within certain stress magnitudes. With increasing stress, the effect of the stress path diminishes.
Optogenetic Study of Anterior BNST and Basomedial Amygdala Projections to the Ventromedial Hypothalamus
Authors: Yamamoto Ryo , Ahmed Nowrin , Ito Tetsufumi , Gungor Nur Zeynep , Pare Denis 
Published: June 2018

AbstractThe basomedial amygdala (BM) influences the ventromedial nucleus of the hypothalamus (VMH) through direct glutamatergic projections as well as indirectly, through the anterior part of the bed nucleus of the stria terminalis (BNSTa). However, BM and BNSTa axons end in a segregated fashion in VMH. BM projects to the core of VMH, where VMH’s projection cells are located, whereas BNSTa projects to the shell of VMH, where GABAergic cells that inhibit core neurons are concentrated. However, the consequences of this dual regulation of VMH by BM and BNSTa are unknown. To study this question, we recorded the responses of VMH’s shell and core neurons to the optogenetic activation of BM or BNSTa inputs in transgenic mice that selectively express Cre-recombinase in glutamatergic or GABAergic neurons. Glutamatergic BM inputs fired most core neurons but elicited no response in GABAergic shell neurons. Following BM infusions of AAV-EF1α-DIO-hChR2-mCherry in Vgat-ires-Cre-Ai6 mice, no anterograde labeling was observed in the VMH, suggesting that GABAergic BM neurons do not project to the VMH. In contrast, BNSTa sent mostly GABAergic projections that inhibited both shell and core neurons. However, BNSTa-evoked IPSPs had a higher amplitude in shell neurons. Since we also found that activation of GABAergic shell neurons causes an inhibition of core neurons, these results suggest that depending on the firing rate of shell neurons, BNSTa inputs could elicit a net inhibition or disinhibition of core neurons. Thus, the dual regulation of VMH by BM and BNSTa imparts flexibility to this regulator of defensive and social behaviors.
El pensamiento centroamericano del siglo XIX: política y educación (Central American Thought in the 19th Century: Politics and Education)
Authors: Camacho Guzmán Gustavo , Bonilla Corrales Karen 
Published: June 2018

El siglo XIX marcó cambios en el accionar político y social de la región centroamericana. Mediante el ensayo, el pensamiento intelectual de los principales personajes del Istmo se manifestó de manera prolífica. Sus reflexiones se orientaban a la creación de propuestas sobre nuevos modos de vida de las antiguas colonias, a la vez que surgieron los proyectos de identidad nacional en los cinco países de la región, ahora independientes. Este artículo muestra un somero panorama de las principales posturas adoptadas en la educación y la religión como ejes transversales de la praxis política y cultural de estos intelectuales. Abstract The nineteenth century marked the political and social action of the Central American region. Through the essay, the intellectual thought of the outstanding figures of this isthmus became prolific. Their reflections were oriented towards the creation of proposals on new ways of life in the old colonies. At the same time projects for the national identity of the independent countries of the region also appeared. This article provides a brief overview of the main positions in education and religion cutting across the political and cultural praxis of these intellectuals.
Identifier, déchiffrer et interpréter le code énigmatique dans l’œuvre de Jean Ray : vers une lecture policière du conte « Le Gardien du Cimetière » (Identificar, descifrar e interpretar el código enigmático en la obra de Jean Ray: hacia una lectura detectivesca del cuento « Le Gardien du Cimetière »)
Authors: Jiménez Murillo Juan Carlos 
Published: June 2018

Cet article se propose de montrer les relations existantes entre le récit fantastique et le récit policier à travers l’analyse du conte « Le Gardien du Cimetière » de l’écrivain belge Jean Ray. La coexistence de ces deux registres littéraires à l’intérieur de ce conte, constitue l’occasion de se centrer sur le rôle du lecteur, conçu celui-ci comme un détective qui doit se livrer à un travail de développement de stratégies de lecture. Sous la forme d’une suite de neuf étapes, à partir du modèle proposé par le tchèque Jiří Šrámek, le lecteur doit s’interroger, repérer les indices, les étudier et les trier pour aboutir enfin au dénouement de l’énigme. Resumen Este artículo describe las relaciones existentes entre el relato fantástico y el policíaco mediante el análisis del cuento «El guardián del cementerio»/«El guarda del cementerio», del escritor belga Jean Ray. La coexistencia de dos registros literarios dentro de la historia permite centrarse en la función del lector, percibido como un detective que debe desarrollar varias estrategias de lectura. A lo largo de nueve etapas, según el modelo planteado por Jiří Šrámek, el lector debe cuestionarse, identificar pistas, estudiarlas y clasificarlas para finalmente lograr la resolución del enigma.
Spektroskopija dokumentinio paveldo autentiškumo tyrimuose: Supraslės vienuolyno raštinės atvejis
Authors: Žižiūnas Tadas 
Published: June 2018

[full article and abstract in Lithuanian; abstract in English]
The aim of the article was to create a research methodology for questioned historical documents where UV-VIS-NIR reflectance spectroscopy is used to identify color variations of historical documents written with iron gall ink. Such methodology was introduced because most historical documents are written with iron gall ink. Secondly, iron gall ink is causing various damage to historical documents hence new and effective research methods are needed. Thirdly, such new methodologies should be accessible for humanities and social science where no specific chemical knowledge is needed.20 volumes of Supraslis abbey office’s historical documents were selected as a case study to test the created methodology. Each book was numbered and labeled with the known provenance. In each book three pages (in the beginning, in the middle and in the end) were selected and two measurements (in the top of the page and in the end) were taken. Also so called Q page (questioned) was de visu selected as different from other pages which turned out 79% not being thecase. What is more, all measurement’s exact spots were also micro- photographed and macro – photographed to make sure that the measured ink samples that were selected had no stains, were not damaged or otherwise polluted. Measurements were performed with CRAIC PV 308 spectrophotometer calculating 900 measurements average for one value of ∼1mm2 sample area.The case study demonstrated that UV-VIS-NIR reflectance spectroscopy can be a very fast and nondestructive tool to investigate historical questioned documents, certain pages of a documenet or even to compare several books from the same or different time periods and place origin. However, effective research require ink color comparison with color maps or other mathematical representation models (e.g. MacAdam’s ellipse). Furthermore, for more precise comparison, big databases with books, origin dates, origin place, spectral data, physical condition and other related parameters are needed.
Estilos de Aprendizagem e Ensino a Distância na Perspectiva da Inclusão
Authors: Souza Suellen Silva dos Santos de , Aragon Glauca Torres 
Published: June 2018

Este estudo analisa como a Educação a Distância pode, ao reconhecer os estilos de aprendizagem, contribuir para a inclusão educacional. Para isso, foi realizada pesquisa bibliográfica acerca da temática, considerando o período referente aos últimos cinco anos, nas bases de dados Pubmed, SciELO e Google Acadêmico. Constatou-se que os estilos de aprendizagem são importantes instrumentos a serem considerados nos processos de ensino-aprendizagem integrados à modalidade de ensino a distância, sendo esse um instrumento de política pública educacional de democratização de acesso à educação. Assim, articular os diversos estilos de aprendizagem e as propostas pedagógicas no ensino a distância resulta em um processo de viabilização de direitos para os que possuem necessidades educativas especiais ou para os que necessitem desenvolver/estimular outros estilos de aprendizagem, atendendo a políticas voltadas à inclusão educacional. Diante disso, espera-se dos diferentes sistemas de ensino maior atenção no sentido do planejamento contínuo de ações para que seja reforçada a formação continuada dos professores na temática debatida, bem como intervir para que políticas públicas educacionais vigentes, em especial a Educação a Distância, sejam efetivamente acessíveis aos estudantes com necessidades educativas especiais. Palavras-chave: Educação a Distância, Inclusão educacional, Neurociências, Neuroeducação. Learning Styles and Distance Education in the Perspective of Inclusion AbstractThis study analyzes how distance education can, by recognizing learning styles, contribute to inclusive education. A bibliographic research in Pubmed, Scielo and Google Academic databases was done on the topic, considering as the period of investigation the last five years. It was verified that learning styles are important instruments to be considered in the teaching-learning process for distance learning, that being an instrument of an educational public policy for democratic access to education. Thus, considering the different learning styles on pedagogical proposals in distance learning results in a process of making rights available to those with special educational needs or those who need to develop/stimulate other learning styles, taking into account policies aimed to inclusive education.Therefore, it is expected that the different educational systems pay more attention in the planning for continuing education to reinforce the ongoing teachers training with the topic discussed, as well as make sure that existing public education policies, especially for distance education, be effectively accessible to students with special needs. Keywords: Distance learning, Inclusive education, Neuroeducation, Neurosciences.