bluuebunny/crossref_metadata_2025_split huggingface dataset:
“Flipping or flapping?” investigating engineering students’ experience in flipped classrooms
Authors: Chew Esyin , Jones Lim Jen Nee , Wordley Scott 
Published: October 2018

PurposeThis study has explored the flipped classroom model in a private university in Malaysia. It aims to present a flipped classroom intervention for engineering education innovation.Design/methodology/approachThe research (1) revisited prominent educational theories for a flipping or flapping pedagogy, (2) implemented and explored the flipped classroom experiences in one engineering subject using the action inquiry method with thematic analysis and (3) reflectively evaluated both students’ and educators’ “flipping or flapping experience”.FindingsThe responses of the research participants are analysed and used to develop the flipping or flapping classroom principles and an ideal flipped classroom model. From passive lectures to active learning with collaborative discourse and reflective communication, flipping the classroom can offer a seamless learning experience.Research limitations/implicationsThe flipped classroom model can provide good reference for other educational researchers who intended to conduct a flipped classroom. However, the small sample size with qualitative method and thematic analysis useds led to considerable theoretical development, but it may not achieve the validity standards to generalise the findings. Further empirical investigation with a systematic controlled group is recommended for future work across disciplines for extrapolation.Originality/valueThis is a genuine case study with an identified innovative teaching need to investigate how flipped classrooms can be enabled and enhanced in engineering education innovation.
2-D periodic structures. A numerical study
Authors: Rocchetta Giuseppe , Mancusi Geminiano 
Published: October 2018

Purpose
Within the context of 2D square lattices, searching for the existence of band gaps assumes a great interest owing to many possible fields of application: from energy absorption devices to noise and vibration controllers, as well as advanced strategies for the seismic isolation.

Design/methodology/approach
The underlying microstructure may influence the mechanical response of 2D square lattices according to a complex interplay between different factors. A first one is related to the so-called “size-effect”. A second one relates, instead, to the mass density distribution.

Findings
It has been observed that lumped masses may induce additional band gaps to appear and may magnify their width. Finally, an additional factor deals with the inner damping characteristics of the constituent materials, which usually are polymer-based.

Originality/value
This study focuses on the first factor from a specific perspective: to investigate the influence of the size effect on the existence and properties of frequency band gaps.
Fractional relaxation model of materials obtained with selective laser sintering technology
Authors: Bochnia Jerzy , Blasiak Slawomir 
Published: October 2018

Purpose
The purpose of this paper was to verify the possibility of applying differential calculus of incomplete order to describe relaxation of the material obtained using selective laser sintering (SLS) technology.

Design/methodology/approach
The samples were made using the incremental technology for three print directions. Relaxation tests were conducted. The theoretical curves, which are the solution of the equation describing the five-parameter Maxwell-Wiechert model for derivatives in relation to the total time of complete order and fractional order, were adjusted to the obtained experimental curves.

Findings
The SLS technology creates new possibilities regarding modelling polymeric elements which might be applied as functional models (products). Therefore, it is necessary to conduct an in-depth study of their properties, including relaxation properties, which is associated with the necessity to use proper mathematical tools to describe those properties. The differential calculus of incomplete order was applied herein to describe the anisotropy of relaxation properties because of the print direction in relation to the relaxation curves adjusted with the five-parameter Maxwell-Wiechert model.

Research limitations/implications
As a result of the conducted considerations, the authors obtained the dependencies describing the anisotropy of relaxation properties with the use of coefficients alpha and beta, which stand for the derivative order of the differential equation, whereas coefficient kappa stands for the translation coefficient which is an innovative application of this type of mathematical apparatus.

Practical implications
The developed method might be applied to describe the anisotropy of a broader group of materials manufactured with the use of incremental technologies.

Originality/value
The application of the differential calculus of incomplete order to describe the anisotropy of the materials manufactured from polyamide powder using the SLS technology is a distinctive feature of this paper. A crucial cognitive element of the conducted research is the fact which confirms that the dynamic viscosity coefficients have the greatest impact on the anisotropy of material properties depending on the print directions.
Accounting for social return on investment (SROI)
Authors: Bellucci Marco , Nitti Carmela , Franchi Serena , Testi Enrico , Bagnoli Luca 
Published: October 2018

PurposeThis study aims to assess the effectiveness of social return on investment (SROI) as a measure of the social impact produced by non-profit organisations and social enterprises that support family-centred care, an approach that focuses on the pivotal role of families in paediatric health care.Design/methodology/approachThe study offers an analytical evaluation of the SROI created by the Italian branch of the Ronald McDonald House Charities and highlights (a) the participatory analysis of stakeholders and outcomes; (b) the measurement of inputs; (c) the definition of outputs and proxies for the measurement of outcomes; (d) the calculation of the SROI ratio; and (e) the results of a sensitivity analysis.FindingsThis study discusses the advantages and shortcomings of SROI analyses, the practical implications of this research on governance and management and the role of engagement in managing the expectations of stakeholders. The value of SROI measurements in shaping strategic and management decisions – with special emphasis on stakeholder relations – is also discussed.Originality/valueNon-profit organisations and social enterprises often require tools that assess the outcomes of their activities. The present research can provide new guidance to SROI analysts, while drawing attention to the most suitable proxies and indicators for evaluating the SROI of organisations operating in the health care sector.
Impact of nonlinear radiative nanoparticles on an unsteady flow of a Williamson fluid toward a permeable convectively heated shrinking sheet
Authors: Zaib Aurang , Haq Rizwan Ul , Chamkha A.J. , Rashidi M.M. 
Published: October 2018

PurposeThe study aims to numerically examine the impact of nanoparticles on an unsteady flow of a Williamson fluid past a permeable convectively heated shrinking sheet.Design/methodology/approachIn sort of the solution of the governing differential equations, suitable transformation variables are used to get the system of ODEs. The converted equations are then numerically solved via the shooting technique.FindingsThe impacts of such parameters on the velocity profile, temperature distribution and the concentration of nanoparticles are examined through graphs and tables. The results point out that multiple solutions are achieved for certain values of the suction parameter and for decelerating flow, while for accelerating flow, the solution is unique. Further, the non-Newtonian parameter reduces the fluid velocity and boosts the temperature distribution and concentration of nanoparticles in the first solution, while the reverse drift is noticed in the second solution.Practical implicationsThe current results may be used in many applications such as biomedicine, industrial, electronics and solar energy.Originality/valueThe authors think that the current results are new and significant, which are used in many applications such as biomedicine, industrial, electronics and solar energy. The results have not been considered elsewhere.
Mechanochemical-assisted heterogeneous surface modification of parawood microcrystalline cellulose and its effect on the properties of polypropylene composites
Authors: Chuayplod Patcharaporn , Aht-Ong Duangdao 
Published: October 2018

PurposeThe purpose of this work was to modify the surface of parawood sawdust (Hevea brasiliensis) microcrystalline cellulose (PW-MCC) used as reinforcing agent in polypropylene composites with benzoyl chloride under a mechanochemistry process.Design/methodology/approachThe acetylated PW-MCC was produced from heterogeneous condition using planetary ball mill process at a rotation speed of 400 rpm. Before the esterification reaction, PW-MCC was pre-treated with pyridine at 60°C for 1 h in order to penetrate and swell the cellulose structure. The optimum condition of esterified PW-MCC with various molar ratios of benzoyl chloride/anhydroglucose unit (AGU) was studied. The degree of substitution, functional group, thermal stability and morphology of esterified cellulose were characterized by1H-nuclear magnetic resonance (NMR), Fourier transform infrared spectroscopy (FTIR), thermogravimetric analyzer (TGA) and scanning electron microscopy (SEM).FindingsThe functional group from FTIR confirmed that PW-MCC was successfully esterified with benzoyl chloride. The optimum condition which gave the maximum degree of substitution at 3.00 was achieved by using benzoyl chloride/AGU at 5 for 1 h. SEM analysis revealed that the modified PW-MCC surface became rougher than the unmodified PW-MCC surface. The polypropylene composites with 5-30 wt% PW-MCC and esterified PW-MCC were prepared without compatibilizer.Originality/valueThe composites with esterified PW-MCC enhanced water resistance and thermal stability when compared to composites with PW-MCC.
Clinical and microbiological response of mice to intranasal inoculation with Lactococcus lactis expressing Group A Streptococcus antigens, to be used as an anti‐streptococcal vaccine
Authors: García Patricia C. , Paillavil Braulio A. , Scioscia Natalia , Dale James B. , Legarraga Paulette , Salazar‐Echegarai Francisco J. , Bueno Susan M. , Kalergis Alexis M. , Wozniak Aniela 
Published: October 2018

ABSTRACTProtein subunit vaccines are often preferred because of their protective efficacy and safety. Lactic acid bacteria expressing heterologous antigens constitute a promising approach to vaccine development. However, their safety in terms of toxicity and bacterial clearance must be evaluated. Anti‐Streptococcus pyogenes (S. pyogenes) vaccines face additional safety concerns because they may elicit autoimmune responses. The assessment of toxicity, clearance and autoimmunity of an anti‐streptococcal vaccine based on Lactococcus lactis (L. lactis) expressing 10 different M protein fragments from S. pyogenes (L. lactis‐Mx10) is here reported. Clearance of L. lactis from the oropharynges of immunocompetent mice and mice devoid of T/B lymphocytes mice was achieved without using antibiotics. The absence of autoimmune responses against human tissues was demonstrated with human brain, heart and kidney. Assessment of toxicity showed that leucocyte counts and selected serum biochemical factors were not affected in L. lactis‐Mx10‐immunized mice. In contrast, mice immunized with L. lactis wild type vector (L. lactis‐WT) showed increased neutrophil and monocyte counts and altered histopathology of lymph nodes, lungs and nasal epithelium. Two days after immunization, L. lactis‐Mx10‐immunized and L. lactis‐WT‐immunized mice weighed significantly less than unimmunized mice. However, both groups of immunized mice recovered their body weights by Day 6. Our results demonstrate that L. lactis‐WT, but not the vaccine L. lactis‐Mx10, induces alterations in certain hematologic and histopathological variables. We consider these data a major contribution to data on L. lactis as a bacterial vector for vaccine delivery.
External validation and clinical usefulness of first‐trimester prediction models for small‐ and large‐for‐gestational‐age infants: a prospective cohort study
Authors: Meertens LJE , Smits LJM , van Kuijk SMJ , Aardenburg R , van Dooren IMA , Langenveld J , Zwaan IM , Spaanderman MEA , Scheepers HCJ 
Published: October 2018

ObjectiveTo assess the external validity of all published first‐trimester prediction models based on routinely collected maternal predictors for the risk of small‐ and large‐for‐gestational‐age (SGA and LGA) infants. Furthermore, the clinical potential of the best‐performing models was evaluated.DesignMulticentre prospective cohort.SettingThirty‐six midwifery practices and six hospitals (in the Netherlands).PopulationPregnant women were recruited at <16 weeks of gestation between 1 July 2013 and 31 December 2015.MethodsPrediction models were systematically selected from the literature. Information on predictors was obtained by a web‐based questionnaire. Birthweight centiles were corrected for gestational age, parity, fetal sex, and ethnicity.Main outcome measuresPredictive performance was assessed by means of discrimination (C‐statistic) and calibration.ResultsThe validation cohort consisted of 2582 pregnant women. The outcomes of SGA <10th percentile and LGA >90th percentile occurred in 203 and 224 women, respectively. The C‐statistics of the included models ranged from 0.52 to 0.64 for SGA (n = 6), and from 0.60 to 0.69 for LGA (n = 6). All models yielded higher C‐statistics for more severe cases of SGA (<5th percentile) and LGA (>95th percentile). Initial calibration showed poor‐to‐moderate agreement between the predicted probabilities and the observed outcomes, but this improved substantially after recalibration.ConclusionThe clinical relevance of the models is limited because of their moderate predictive performance, and because the definitions of SGA and LGA do not exclude constitutionally small or large infants. As most clinically relevant fetal growth deviations are related to ‘vascular’ or ‘metabolic’ factors, models predicting hypertensive disorders and gestational diabetes are likely to be more specific.Tweetable abstractThe clinical relevance of prediction models for the risk of small‐ and large‐for‐gestational‐age is limited.
Device exchange versus nonexchange modalities in left ventricular assist device‐specific infections: A systematic review and meta‐analysis
Authors: Bauer Tyler M. , Choi Jae Hwan , Luc Jessica G.Y. , Weber Matthew P. , Moncho Escrivá Ester , Patel Sinal , Maynes Elizabeth J. , Boyle Andrew J. , Samuels Louis E. , Entwistle John W. , Morris Rohinton J. , Massey H. Todd , Tchantchaleishvili Vakhtang 
Published: October 2018

AbstractNo standardized treatment algorithm exists for the management of continuous‐flow left ventricular assist device (CF‐LVAD)‐specific infections. The aim of this systematic review and meta‐analysis was to compare the outcomes of CF‐LVAD‐specific infections as managed by device exchange to other treatment modalities not involving device exchange. Electronic search was performed to identify all studies in the English literature relating to the management of CF‐LVAD‐specific infections. All identified articles were systematically assessed for selection criteria. Thirteen studies with 158 cases of CF‐LVAD‐specific infection were pooled for analysis. Overall, 18/158 (11.4%) patients underwent CF‐LVAD exchange, and 140/158 (88.6%) patients were treated with non‐exchange modalities. The proportion of patients with isolated driveline infections or pump or pocket infections did not differ significantly between the groups. During a mean follow‐up of 290 days, there were no significant differences in the overall mortality [exchange 17.6% (4.3–50.6) vs. non‐exchange 23.3% (15.8–32.9), P = 0.67] and infection recurrence rates [exchange 26.7% (8.7–58.0) vs. non‐exchange 38.6% (15.4–68.5), P = 0.56]. In the setting of CF‐LVAD‐specific infections, device exchange does not appear to confer an advantage in the overall mortality and infection recurrence as compared to non‐exchange modalities.
Rapid antimicrobial susceptibility testing of positive blood cultures by direct inoculation and reading of disc diffusion tests after 3–4 hours
Authors: Weme Einar Tollaksen 
Published: October 2018

The aim of the study was to validate whether rapid antimicrobial susceptibility testing (AST) by very early reading of disc diffusion tests would provide reliable results in daily routine work. A total of 264 positive blood culture bottles were examined, of which 178 were examined as part of the daily routine workflow. Enterobacterales were evaluated for resistance to cefotaxime, ceftazidime, gentamicin and ampicillin. Staphylococcus aureus (S. aureus) was tested for resistance to cefoxitin as a marker of methicillin‐resistant S. aureus (MRSA). The zones were read after 3 h, and if there was insufficient growth, 30 and 60 min later. The results were compared to standard overnight AST. For ampicillin, gentamicin and cefoxitin, there were no errors. For cefotaxime, there were three minor (1.5%), three major (1.5%) and no very major errors. For ceftazidime, there were 13 minor (6.5%) errors only. With the exception of one minor error, all errors were ESBL‐A‐ or AmpC‐producing isolates where rapid AST showed a higher degree of resistance than standard AST. This low‐cost method may contribute to early effective antibacterial treatment by providing reliable results of AST within 3–4 h. Special breakpoints for early reading are a prerequisite.
Laparoscopic excision of an acquired ureteral diverticulum: A case report
Authors: Negoro Hiromitsu , Inoue Takahiro , Imai Kazuto , Goto Takayuki , Sawada Atsuro , Akamatsu Shusuke , Saito Ryoichi , Kobayashi Takashi , Yamasaki Toshinari , Ogawa Osamu 
Published: October 2018

AbstractUreteral diverticula, especially acquired diverticula, are rare. Surgery is indicated when a diverticulum is accompanied by complications such as stones, pyelonephritis, stenosis, and signs of malignancy. A 59‐year‐old woman visited our urology department with asymptomatic macrohematuria. Enhanced CT scan revealed a right ureteral diverticulum with a 16‐mm diameter that contained two tiny stones inside. After 8 months, the size of these stones increased; therefore, the patient underwent laparoscopic resection of the ureteral diverticulum and end‐to‐end anastomosis of the ureter. Subsequent histopathology of the excised specimen revealed an acquired diverticulum. Follow‐up intravenous pyelography showed adequate urine passage with only minor dilatation of the pelvis at 3 months after the operation. The laparoscopic approach is believed to be feasible for ureteral diverticula cases that require ureteral end‐to‐end anastomosis.
Professionals’ Perspectives on Viewing Child Sexual Abuse Images to Improve Response to Victims
Authors: Slane Andrea , Martin Jennifer , Rimer Jonah R. , Eke Angela W. , Sinclair Roberta , Charles Grant , Quayle Ethel 
Published: October 2018

AbstractThe complexity of the phenomenon of child sexual abuse images online (CSAIO) benefits from cross‐disciplinary collaboration across law enforcement, child protection, and children's mental health. Through focus groups with professionals working in these fields, this article focuses on when and whether professionals who work with child sexual abuse cases should be exposed to viewing CSAIO and if so under what circumstances doing so would benefit investigations and support services for victims. In a broader sense, this article is about professional experience, decision making, training, and collaboration around a particularly difficult professional experience, namely exposure to viewing CSAIO.
AID and TET2 co-operation modulates FANCA expression by active demethylation in diffuse large B cell lymphoma
Authors: Jiao J , Jin Y , Zheng M , Zhang H , Yuan M , Lv Z , Odhiambo W , Yu X , Zhang P , Li C , Ma Y , Ji Y 
Published: October 2018

Summary
Diffuse large B cell lymphoma (DLBCL) is traced to a mature B malignance carrying abnormal activation-induced cytidine deaminase (AID) expression. AID activity initially focuses on deamination of cytidine to uracil to generate somatic hypermutation and class-switch recombination of the immunoglobulin (Ig), but recently it has been implicated in DNA demethylation of genes required for B cell development and proliferation in the germinal centre (GC). However, whether AID activity on mutation or demethylation of genes involves oncogenesis of DLBCL has not been well characterized. Our data demonstrate that the proto-oncogene Fanconi anaemia complementation group A (FANCA) is highly expressed in DLBCL patients and cell lines, respectively. AID recruits demethylation enzyme ten eleven translocation family member (TET2) to bind the FANCA promoter. As a result, FANCA is demethylated and its expression increases in DLBCL. On the basis of our findings, we have developed a new therapeutic strategy to significantly inhibit DLBCL cell growth by combination of the proteasome inhibitor bortezomib with AID and TET2 depletion. These findings support a novel mechanism that AID has a crucial role in active demethylation for oncogene activation in DLBCL.
Altered metabolic pathways regulate synovial inflammation in rheumatoid arthritis
Authors: Fearon U , Hanlon M M , Wade S M , Fletcher J M 
Published: October 2018

Summary
Rheumatoid arthritis is characterized by synovial proliferation, neovascularization and leucocyte extravasation leading to joint destruction and functional disability. The blood vessels in the inflamed synovium are highly dysregulated, resulting in poor delivery of oxygen; this, along with the increased metabolic demand of infiltrating immune cells and inflamed resident cells, results in the lack of key nutrients at the site of inflammation. In these adverse conditions synovial cells must adapt to generate sufficient energy to support their proliferation and activation status, and thus switch their cell metabolism from a resting regulatory state to a highly metabolically active state. This alters redox-sensitive signalling pathways and also results in the accumulation of metabolic intermediates which, in turn, can act as signalling molecules that further exacerbate the inflammatory response. The RA synovium is a multi-cellular tissue, and while many cell types interact to promote the inflammatory response, their metabolic requirements differ. Thus, understanding the complex interplay between hypoxia-induced signalling pathways, metabolic pathways and the inflammatory response will provide better insight into the underlying mechanisms of disease pathogenesis.
Hungry, Hungry Gringos: Solving the Problems Posed by Feeding Tourists
Authors: Griffith Lauren Miller 
Published: October 2018

AbstractTourist demand for food stuffs like delicate lettuce varieties that are ill‐suited to the local environment are setting off a chain of reactions within the Cayo District of Belize. To meet demand, farmers are learning to grow these crops organically, synthesizing knowledge from a variety of sources in order to succeed in this new market. This paper takes readers through the experiences of villagers who work in several key sites of a luxury eco‐resort—the restaurant, kitchen, store room, and organic farm—before turning to the implications for the village at large. Though catering to tourists’ tastes is often treated as a form of neocolonialism, this case study examines the agency and creativity expressed by local community members as they adapt to this changing market.