bluuebunny/crossref_metadata_2025_split huggingface dataset:
Acellular dermal matrix contributes to epithelialization in patients with chronic sinusitis
Authors: Bing Zhong , Feng Liu , Wu Chun-Shu , Du Jin-Tao , Liu Ya-Feng , Liu Shi-Xi 
Published: January 2019

Background Nasal endoscopic surgery is widely used for nasal diseases, including sinusitis and tumors. However, scar hyperplasia, nasal irritation, scab, and nasal obstruction delay nasal mucosal recovery, with prolonged cleaning exacerbating the patient's financial burden. Here, we presented a novel approach for the treatment of nasal mucosal defects, termed acellular dermal matrix. Methods A total of 31 patients with bilateral chronic sinusitis (maxillary sinusitis and ethmoid sinusitis) underwent nasal surgery and nasal mucosal repair in September–October 2016. We divided the nasal cavities of each patient into control and acellular dermal matrix groups, randomly selected one side for nasal mucosal repair by surgery. A suitable acellular dermal matrix size was selected according to the defect in each patient. After pruning, the acellular dermal matrix was placed on the wound surface and filled with gelatin sponge. All patients were followed up for 14 weeks to compare nasal mucosal epithelialization between the control and acellular dermal matrix groups. Results：No obvious complications and adverse reactions were observed after nasal surgery. Lund-Kennedy scores in the acellular dermal matrix group were significantly decreased compared with the control group at 8 (0 (0, 1) vs. 2 (2, 4); P<0.05) weeks. Epithelialization time of eight weeks in the acellular dermal matrix groups was significantly decreased than the control group of 14 weeks. Conclusion Acellular dermal matrix provides a growth framework for the healthy mucosa on the wounded surface and reduces postoperative epithelialization time.
Health Disparities in Hospice Utilization and Length of Stay in a Diverse Population With Lung Cancer
Authors: Johnson Lee Ann , Blew Amy , Schreier Ann M. 
Published: January 2019

Background: Lung cancer is the leading cause of cancer deaths globally. Individuals are diagnosed at an advanced stage with limited life expectancy. Objectives: To explore potential health disparities in hospice utilization and length of stay (LOS) in a diverse sample of patients with lung cancer. Methods: Demographic and clinical information as well as data for hospice utilization and LOS was extracted from electronic health records. Data were analyzed using descriptive statistics, χ2 tests, and an analysis of variance test. Results: Data from 242 patients were analyzed. In the sample, 33% (n = 80) were Black and 51% (n = 124) lived in a rural county. At the time of data collection, 67% of the sample was deceased and 36% (n = 86) chose to enroll in hospice. No disparities were found for race, age, gender, or rural/urban dwellers in hospice enrollment. No disparities were found for race, gender, or rural/urban dwellers for hospice LOS. Age was associated with hospice LOS ( P = .004). Those who were older were more likely to have a longer LOS. Conclusion: Hospice utilization and LOS were low for all groups with lung cancer in a geographically and racially diverse region of the United States. Given the rates of mortality in lung cancer, discussions about the goals and benefits of hospice care may be beneficial and should be part of an ongoing dialogue throughout the disease trajectory.
The impact of in hospital patient-education intervention on older people’s attitudes and intention to have their benzodiazepines deprescribed: a feasibility study
Authors: Gnjidic Danijela , Ong Hui Min Magdalene , Leung Celeste , Jansen Jesse , Reeve Emily 
Published: January 2019

Background: Long-term benzodiazepine use in the older population is common and is associated with significant harm. The provision of a patient-educational booklet during hospitalization may encourage patients to discuss review and possible deprescribing of benzodiazepine therapy with their health professionals. The aim of this study was to assess the feasibility and effect of a patient empowerment intervention in hospital inpatients on patient initiation of a discussion about deprescribing benzodiazepines versus usual care. Methods: A feasibility interventional study using a patient-empowerment education intervention was conducted at a Sydney teaching hospital. Patients aged ⩾ 65 years, prescribed a benzodiazepine, and able to provide consent were invited to participate in the study. Participants were randomly allocated to intervention or control group (1:1). Intervention participants received the patient-empowerment booklet and control received usual care. All participants received 1-month follow-up phone interviews to assess medication and attitudinal changes. Results: A total of 42 participants were recruited (20 intervention and 22 control). The average age was 71.5 (interquartile range: 69.0–80.3) and 54.8% were females. There was no difference in baseline characteristics between intervention and control groups ( p > 0.05). At baseline, 65.0% of participants (53.0% intervention, 86.0% control) were not concerned about the potential benzodiazepine side effects. Twenty-nine participants (15 intervention and 14 control) completed 1-month follow up; 22 participants (11 intervention and 11 control) were discharged on the benzodiazepine. Among these, 13 (59.1%) had ceased benzodiazepine at 1-month follow up [46.2% ( n = 6) intervention; 53.8% ( n = 7) control]. In the intervention group, 33.3% ( n = 5) of participants had initiated a discussion with their doctor or pharmacist about stopping the benzodiazepine compared with 35.7% ( n = 5) in the control group. Conclusion: Cessation of benzodiazepines 1 month following discharge was common. Future larger studies are required to confirm the effectiveness of providing a patient-empowerment booklet on reducing benzodiazepine use and other potentially inappropriate medications.
Altered enteric expression of the homeobox transcription factor Phox2b in patients with diverticular disease
Authors: Cossais François , Lange Christina , Barrenschee Martina , Möding Marie , Ebsen Michael , Vogel Ilka , Böttner Martina , Wedel Thilo 
Published: January 2019

BackgroundDiverticular disease, a major gastrointestinal disorder, is associated with modifications of the enteric nervous system, encompassing alterations of neurochemical coding and of the tyrosine receptor kinase Ret/GDNF pathway. However, molecular factors underlying these changes remain to be determined.ObjectivesWe aimed to characterise the expression of Phox2b, an essential regulator of Ret and of neuronal subtype development, in the adult human enteric nervous system, and to evaluate its potential involvement in acute diverticulitis.MethodsSite‐specific gene expression of Phox2b in the adult colon was analysed by quantitative polymerase chain reaction. Colonic specimens of adult controls and patients with diverticulitis were subjected to quantitative polymerase chain reaction for Phox2b and dual‐label immunochemistry for Phox2b and the neuronal markers RET and tyrosine hydroxylase or the glial marker S100β.ResultsThe results indicate that Phox2b is physiologically expressed in myenteric neuronal and glial subpopulations in the adult enteric nervous system. Messenger RNA expression of Phox2b was increased in patients with diverticulitis and both neuronal, and glial protein expression of Phox2b were altered in these patients.ConclusionsAlterations of Phox2b expression may contribute to the enteric neuropathy observed in diverticular disease. Future studies are required to characterise the functions of Phox2b in the adult enteric nervous system and to determine its potential as a therapeutic target in gastrointestinal disorders.
Human neutrophils express low levels of FcγRIIIA, which plays a role in PMN activation
Authors: Golay Josée , Valgardsdottir Rut , Musaraj Gerta , Giupponi Damiano , Spinelli Orietta , Introna Martino 
Published: January 2019

Abstract
We have identified a rare healthy FcγRIIIB (CD16B)-null donor completely lacking FCGR3B RNA and protein expression and dissected the role of the different neutrophil Fcγ receptors in the response to therapeutic anti-CD20 monoclonal antibodies. We observed that polymorphonuclear neutrophils (PMNs) from FcγRIIIB wild-type (WT) individuals or the null donor were more effectively activated by chronic lymphocytic leukemia (CLL) B-cell targets opsonized with glycoengineered anti-CD20 antibodies compared with fully core-fucosylated anti-CD20 antibodies, suggesting the presence and role of FcγRIIIA (CD16A) on PMNs. Indeed, we demonstrated by reverse-transcription polymerase chain reaction, flow cytometry, and western blot analysis that PMNs from FcγRIIIB WT donors and the null individual express low levels of FcγRIIIA on their surfaces. FcγRIIIA is a functional and activating molecule on these cells, because anti-CD16 F(ab′)2 antibodies alone were able to activate highly purified PMNs from the FcγRIIIB-null donor. Use of blocking anti-CD16 and anti-CD32 antibodies showed that FcγRIIIA is also a major mediator of phagocytosis of CD20-opsonized beads by FcγRIIIB WT and null PMNs. In contrast, trogocytosis of antibody-opsonized CLL B cells by PMNs was mediated primarily by FcγRIIIB in WT PMNs and by FcγRIIA in null PMNs. We conclude that FcγRIIIA is an important player in PMN functions, whereas FcγRIIIB is dispensable for activation and phagocytosis. We discuss the clinical implications of these findings.
Targeting of cathepsin S reduces cystic fibrosis-like lung disease
Authors: Small Donna M. , Brown Ryan R. , Doherty Declan F. , Abladey Anthony , Zhou-Suckow Zhe , Delaney Rebecca J. , Kerrigan Lauren , Dougan Caoifa M. , Borensztajn Keren S. , Holsinger Leslie , Booth Robert , Scott Christopher J. , López-Campos Guillermo , Elborn J. Stuart , Mall Marcus A. , Weldon Sinéad , Taggart Clifford C. 
Published: January 2019

Cathepsin S (CatS) is upregulated in the lungs of patients with cystic fibrosis (CF). However, its role in CF lung disease pathogenesis remains unclear.In this study, β-epithelial Na+channel-overexpressing transgenic (βENaC-Tg) mice, a model of CF-like lung disease, were crossed with CatS null (CatS−/−) mice or treated with the CatS inhibitor VBY-999.Levels of active CatS were elevated in the lungs of βENaC-Tg mice compared with wild-type (WT) littermates. CatS−/−βENaC-Tg mice exhibited decreased pulmonary inflammation, mucus obstruction and structural lung damage compared with βENaC-Tg mice. Pharmacological inhibition of CatS resulted in a significant decrease in pulmonary inflammation, lung damage and mucus plugging in the lungs of βENaC-Tg mice. In addition, instillation of CatS into the lungs of WT mice resulted in inflammation, lung remodelling and upregulation of mucin expression. Inhibition of the CatS target, protease-activated receptor 2 (PAR2), in βENaC-Tg mice resulted in a reduction in airway inflammation and mucin expression, indicating a role for this receptor in CatS-induced lung pathology.Our data indicate an important role for CatS in the pathogenesis of CF-like lung disease mediated in part by PAR2 and highlight CatS as a therapeutic target.
What should be the protein target for adjustable Human Milk fortification in premature infants?
Authors: Dorum Bayram Ali , Ozkan Hilal , Cakir Salih Cagri , Koksal Nilgun , Sen Gizem Ezgi 
Published: January 2019

Objective: To assess the short- and long-term effects of the adjustable fortification (ADJ) regimen on growth parameters in premature infants and to evaluate the amount of protein supplements given to reach the targeted blood urea nitrogen (BUN) levels.
Methods: In this retrospective study, preterm babies who were born at ≤32 weeks gestational age and fed with human milk, were evaluated in two groups. Infants in Group-I were fed only standard fortification (STD). Infants in Group-II were fed the ADJ regimen. The study was conducted between 2011 and 2016.
Results: There were 123 infants in the STD group and 119 in the ADJ group. The mean gestational age of the patients in Group-I was 29.7±1.8 weeks, and mean birth weight was 1266.1±347.1 g. The mean gestational age of the patients in Group-II was 29.5±1.9 weeks, and the mean birth weight was 1217.5±345.5 g. The daily increase in weight and weekly increase in HC were significantly higher in the ADJ group infants. Weight and HC of infants in the ADJ group were significantly higher at 40 weeks. At one year corrected age, weight, length, and HC measurements of both groups were similar. In Group-II, 63% of patients required additional protein supplementation up to 1.6 g/day to achieve the target BUN levels.
Conclusion: A higher protein intake through the ADJ regimen improves the physical growth rate of premature infants in the NICU and after discharge. However, sometimes, the targeted growth and BUN values ​​cannot be achieved despite the administration of protein at the recommended increased doses. Increasing protein supplementation up to 1.6 g/day is safe, feasible, and beneficial for these infants.
How to cite this:Dorum BA, Ozkan H, Cakir SC, Koksal N, Sen GE. What should be the protein target for adjustable Human Milk fortification in premature infants? Pak J Med Sci. 2019;35(1):277-281. doi: https://doi.org/10.12669/pjms.35.1.337
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Frequency and predictors of pulmonary hypertension in patients with Systemic Lupus Erythematosus
Authors: Asif Sadia , Rasheed Aflak , Mahmud Tafazzul-e-Haque , Asghar Ammad 
Published: January 2019

Objective: To determine the frequency and predictors of pulmonary hypertension in patients with Systemic Lupus Erythematosus in a Pakistani population, presenting at a tertiary care hospital
Methods: This cross-sectional study was conducted at the Department of Rheumatology, Shiekh Zayed Hospital, Lahore from March to June 2018. A total of 97 patients, who fulfilled the Systemic Lupus Erythematosus (SLE) criteria of American College of Rheumatology (ACR) 1992 were enrolled. Pulmonary Arterial Hypertension (PAH) was measured by calculating pulmonary arterial systolic pressure through echocardiography by a single consultant cardiologist. Disease characteristics and demography was collected in a self-administered proforma. PAH was defined as mean pulmonary arterial pressure of 25mmHg or above by calculating with a formula. SPSS version 20 was used for analysis of data.
Results: Out of 97 patients, 89.7% (n=87) were females and 10.3% (n=10) were males, with mean age of 31.29±8.824 years. The mean disease duration was 24.21±30.46 months. PAH was found in 23.3% (n=23) patients, including 19 females and 4 males. On further analysis of data, Raynaud phenomenon, rheumatoid factor and nephritis were assessed as predictors of PAH and all of these showed statistical significance for presence of PAH as per Chi-square test (p<0.05).
Conclusion: In this study, 23.3% SLE patients showed evidence of PAH and positive statistical significance was found between predictors like Raynaud phenomenon, rheumatoid factor, nephritis and presence of PAH. So it is imperative to detect PAH early and start prompt treatment to achieve better quality of life.
How to cite this:Asif S, Rasheed A, Mahmud TH, Asghar A. Frequency and predictors of pulmonary hypertension in patients with Systemic Lupus Erythematosus. Pak J Med Sci. 2019;35(1):86-89. doi: https://doi.org/10.12669/pjms.35.1.405
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Million Migrants study of healthcare and mortality outcomes in non-EU migrants and refugees to England: Analysis protocol for a linked population-based cohort study of 1.5 million migrants
Authors: Burns Rachel , Pathak Neha , Campos-Matos Ines , Zenner Dominik , Katikireddi Srinivasa Vittal , Muzyamba Morris C. , Miranda J. Jaime , Gilbert Ruth , Rutter Harry , Jones Lucy , Williamson Elizabeth , Hayward Andrew C. , Smeeth Liam , Abubakar Ibrahim , Hemingway Harry , Aldridge Robert W. 
Published: January 2019

Background: In 2017, 15.6% of the people living in England were born abroad, yet we have a limited understanding of their use of health services and subsequent health conditions. This linked population-based cohort study aims to describe the hospital-based healthcare and mortality outcomes of 1.5 million non-European Union (EU) migrants and refugees in England. Methods and analysis: We will link four data sources: first, non-EU migrant tuberculosis pre-entry screening data; second, refugee pre-entry health assessment data; third, national hospital episode statistics; and fourth, Office of National Statistics death records. Using this linked dataset, we will then generate a population-based cohort to examine hospital-based events and mortality outcomes in England between Jan 1, 2006, and Dec 31, 2017. We will compare outcomes across three groups in our analyses: 1) non-EU international migrants, 2) refugees, and 3) general population of England. Ethics and dissemination: We will obtain approval to use unconsented patient identifiable data from the Secretary of State for Health through the Confidentiality Advisory Group and the National Health Service Research Ethics Committee. After data linkage, we will destroy identifying data and undertake all analyses using the pseudonymised dataset. The results will provide policy makers and civil society with detailed information about the health needs of non-EU international migrants and refugees in England.
Purification of pulp mill condensates by an adsorptive process on activated carbon
Authors: Gamelas José A.F. , Rebola Sofia M. , Evtyugina Margarita G. , Esteves Valdemar I. , Evtuguin Dmitry V. 
Published: January 2019

Abstract
In order to close the water cycle in pulp mills with condensates instead of fresh water, the malodorous/hazardous volatile compounds and colored substances have to be removed by appropriate efficient methods. In the present work, the condensate from the evaporation of black liquor (BL) from a kraft mill was purified by a batch adsorptive process by means of commercial activated carbon (AC). The effluent was found to contain a wide range of aromatic and organosulfur volatile compounds, including toluene, ethylguaicol, syringaldehyde, dimethyl disulfide (DMDS), dimethyl trisulfide (DMTS), 2,3-dimethylthiophene, benzothiol and benzothiophene derivatives. Methanol was the major volatile organic component in the condensate (201 mg l−1), which was, however, poorly adsorbed on the AC surface. Aromatics and organosulfur contaminants were adsorbed almost completely in 2–5 min at 23°C under the optimized AC load (900 mg l−1). The treatment allowed the elimination of up to 99% of the obnoxious odor, color and turbidity of the condensate. The adsorption equilibrium followed the Langmuir model and the pseudo-second-order kinetics. The new process could be incorporated in the pulp mill with relatively low additional reagent costs.
Teaching Basic Nursing Care: Nurse Preceptors’ Perceptions about Changing the Teaching Context from the Clinical Setting to a School Simulation Lab
Authors: Lillekroken Daniela 
Published: January 2019

AbstractResearch demonstrates that basic nursing care receives less attention in clinical settings and has become visually less prominent in nursing education curriculums. While much is known about the importance of preceptorship in clinical settings, little is known about how preceptors teach basic nursing care to students in a school simulation lab. This study explores the preceptors’ perceptions of teaching basic nursing care to nursing students in the school simulation lab compared to clinical settings. Data were collected through focus group interviews and participant observation and analyzed by using qualitative content analysis. Three main categories emerged: (i) Perceived advantages and disadvantages, (ii) Positive attitudes – remembering being a student, and (iii) Knowing what to do and showing how to do it. Awareness of the importance of having knowledge about basic nursing care may contribute to counterbalancing the devaluation of basic nursing care among nursing students.
Workplace Employee Representation and Industrial Relations Performance: New Evidence from the 2013 European Company Survey
Authors: Addison John T. , Teixeira Paulino 
Published: January 2019

Abstract
Using cross-country data from the European Company Survey, we investigate the relationship between workplace employee representation and management perceptions of the climate of industrial relations, sickness/absenteeism, employee motivation, and staff retention. For a considerably reduced subset of the data, a fifth indicator – strike activity – is also considered alongside the other behavioral outcomes. From one perspective, the expression of collective voice through works council-type entities may be construed as largely beneficial, especially when compared with their counterpart union agencies either operating alone or in a dominant position. However, if heightened distributional struggles explain these differential outcomes in workplace employee representation, it should not go unremarked that the influence of formal collective bargaining is seemingly positive.
The Brown Book of Alice Ambrose
Authors: De Pellegrin Enzo 
Published: January 2019

Abstract
Little is known about the origins of the Brown Book of Ludwig Wittgenstein. One of his better-known texts, it was first published in print in 1958 and is based on notes that Wittgenstein had dictated to two of his pupils, Francis Skinner and Alice Ambrose, at Cambridge University during the academic year of 1934 – 35. The present paper examines some of the few extant remarks by Wittgenstein and others about the circumstances from which the text emerged against the backdrop of various source materials, including a set of handwritten and typed notes that belong to a collection of Ambrose’s papers at Cambridge University Library.
Hinges, Prejudices, and Radical Doubters
Authors: Boncompagni Anna 
Published: January 2019

Abstract
This paper makes use of the Wittgenstein-inspired perspective of hinge epistemology in connection with research on epistemic injustice. Its aim is to shed light on the neglected relationship between hinges and prejudices, by focussing on the role of the “radical doubter” in epistemic practices. After the introduction, section 1 presents Miranda Fricker’s (2007) seminal work and points out that epistemic injustice typically involves the silence of discriminated groups, an aspect that emerges with most clarity when the figure of the doubter is considered. This is further investigated in section 2 with the examination of the film “Twelve Angry Men”, by Sidney Lumet. Some unsolved problems posed by Lumet’s film, rotating around the notion of reasonable doubt, are addressed in the following section through the Wittgensteinian metaphor of hinges as developed in hinge epistemology. Finally, by bringing together epistemic injustice and hinge epistemology, section 4 puts to the fore the importance of cultivating the capacity of attention towards radical doubters for understanding one’s own prejudices and promoting social transformations.