bluuebunny/crossref_metadata_2025_split huggingface dataset:
Terapi Siklosporin Pada Psoriasis Pustulosa Generalisata Dengan Liver Injury Karena Penggunaan Acitretin Jangka Panjang
Authors: Yuniati Renni , Putri Intan Nurmawati 
Published: September 2019

Latar belakang: Psoriasis pustulosa generalisata (PPG) merupakan salah satu jenis psoriasis yang jarang terjadi. Angka kejadian PPG 0,6-0,7 kasus per satu juta jiwa. Gejala khas PPG yaitu terdapat pus steril dengan ukuran 2-3 mm yang tersebar generalisata diatas kulit yang eritem. Terapi yang biasa digunakan diantaranya siklosporin, acitretin, atau metrotekstat. Tujuan: Tujuan dari kasus ini untuk membahas tentang faktor pencetus PPG, pilihan obat, komplikasi, dan efek samping dari terapi PPG jangka panjang.Kasus: Seorang wanita usia 37 tahun dengan riwayat psoriasis datang dengan keluhan terdapat pustula generalisata, makula eritem dan skuama. Faktor predisposisi dan pencetus pada pasien ini adalah obesitas dan stres emosional. Pasien pernah mendapatkan terapi siklosporin selama 3 tahun kemudian diganti asitretin satu tahun terakhir. Hasil histopatologi didapatkan gambaran abses munro dan parakeratosis sesuai dengan PPG. Didapatkan leukositosis dan kelainan tes fungsi hati pada pemeriksaan laboratorium, sehingga terapi kembali diganti dengan siklosporin dosis rendah selama 10 hari dan memberikan hasil yang memuaskan.Pembahasan: PPG merupakan penyakit autoimun. Stres emosional merupakan faktor yang paling berpengaruh; pada kasus ini pasien telah lama menderita PPG dan terapi sistemik jangka panjang, emosi pasien menjadi tidak terkontrol sehingga sering terjadi kekambuhan. Acitretin dapat menyebabkan kerusakan hepar; siklosporin dapat menjadi pilihan yang lebih baik.Â Simpulan: PPG masih menjadi masalah besar. Stres emosional merupakan faktor yang mempengaruhi kejadian PPG. Terapi jangka panjang dan efek samping menyebabkan ketidakpatuhan pasien untuk konsumsi obat. Penting bagi pasien untuk melanjutkan terapi obat sistemik dan mengontrol emosiKata kunci: Psoriasis pustulosa generalisata, Acitretin, Siklosporin, Kerusakan Hepar.Key Words:Â Psoriasis, Hypocalcemia, Hypoparathyroidism, Psoriasis of von ZumbuschPsoriasis is an autoimmune disease triggered by different conditions in genetically susceptible people. It is characterized by variable cutaneous manifestations including localized or disseminated pustules. Generalized pustular psoriasis (GPP) has two main clinical forms: von Zumbusch psoriasis, characterized by severe erythrodermia and scaling skin after the resolution of pustules, and the annular form. GPP may also present severe extracutaneous manifestations including pneumonitis, heart failure and hepatitis. Old reports showed a relationship between hypoparathyroidism and hypocalcemia as triggers for GPP highlighting the importance of adequate workup of the patient and possible therapeutic changes in acute situations. Here, we present a case of severe von Zumbusch psoriasis with life-threatening complications triggered by severe hypocalcemia secondary to hypoparathyroidism successfully treated with aggressive calcium reposition.Key Words:Â Psoriasis, Hypocalcemia, Hypoparathyroidism, Psoriasis of von Zumbusch
Kidney Transplantation in Semarang: Outcomes and Prognosis
Authors: Nugroho Eriawan Agung , Supit Tommy , Santosa Ardy , Daniswara Nanda , Addin Sofyan Rais , Mukti Anggun Ari 
Published: September 2019

Introduction & objective:Kidney transplantationis increasingly performed acrossIndonesia, including in Semarang. However there are limited publications onrenal transplantationfrom Indonesia, especially from centers outside Jakarta. The objective of this case series is to give a brief overview on the transplantation performed in Semarang, discusscurrent issues and ongoing efforts to address them.
Case series:Twenty-seven renal transplants in Dr. Kariadi General Hospital from January2012 until July 2018wereretrospectively analyzed. On average recipients were younger (32.5 years old) compared to the donors (46.8 years old). All kidneys were acquired from living donors with the majority of them to be blood-related(74.1%). The 3 leading etiologies of end-stage renal disease were hypertension (36.0%), diabetes mellitus (26.9%), and autoimmune disease (11.2%). The average total ischemic time was 36.9 minutes andthe average length of stay was 11 days. We report 5 cases of mortality, 3 cases of allograft rejection and no re-transplantation.
Discussion: The demographics of kidney transplant patients in Semarang were similar compared to the National data. The limited number of transplant in Semarang contributes to the low number of survival rate and highlights the need of further training and expertise. Better survival rate can be achieved with more transplants number as well as reaching the plateau of learning curve within the coming years.
Conclusion: The development of kidney transplant in Semarang follows the National milestones. In order to maximize the potentialthe institution, further improvements should concentrate on the development of integrated organ transplant infrastructure. The main goal of this institution is to establish a solid transplant center capable of covering Central Java, aiding the decentralization of kidney transplant in the Nation
Keywords: Kidney transplantation, End-stage Renal Disease, Chronic Kidney Disease, Indonesia, Semarang, Epidemiology, Update
Discovery of Tidally Perturbed Pulsations in the Eclipsing Binary U Gru: A Crucial System for Tidal Asteroseismology
Authors: Bowman Dominic M. , Johnston Cole , Tkachenko Andrew , Mkrtichian David E. , Gunsriwiwat Khemsinan , Aerts Conny 
Published: September 2019

Abstract
The interior physics of stars is currently not well constrained for early-type stars. This is particularly pertinent for multiple systems, as binary interaction becomes more prevalent for more massive stars, which strongly affects their evolution. High-precision photometry from the Transiting Exoplanet Survey Satellite (TESS) mission offers the opportunity to remedy the dearth of observations of pulsating stars that show evidence of binary interaction, specifically pulsating mass-accreting components of semi-detached Algol-type eclipsing binary (oEA) systems. We present the TESS light curve of the circular eclipsing binary system U Gru (TIC 147201138), which shows evidence of free heat-driven pressure modes and a series of tidally perturbed pressure modes. We highlight the asteroseismic potential of studying pulsating stars in binary systems, and demonstrate how tidal asteroseismology can be applied to infer the influence of binary interaction on stellar structure.
29P/Schwassmann–Wachmann 1, A Centaur in the Gateway to the Jupiter-family Comets
Authors: Sarid G. , Volk K. , Steckloff J. K. , Harris W. , Womack M. , Woodney L. M. 
Published: September 2019

Abstract
Jupiter-family comets (JFCs) are the evolutionary products of trans-Neptunian objects (TNOs) that evolve through the giant planet region as Centaurs and into the inner solar system. Through numerical orbital evolution calculations following a large number of TNO test particles that enter the Centaur population, we have identified a short-lived dynamical Gateway, a temporary low-eccentricity region exterior to Jupiter through which the majority of JFCs pass. We apply an observationally based size distribution function to the known Centaur population and obtain an estimated Gateway region population. We then apply an empirical fading law to the rate of incoming JFCs implied by the the Gateway region residence times. Our derived estimates are consistent with observed population numbers for the JFC and Gateway populations. Currently, the most notable occupant of the Gateway region is 29P/Schwassmann–Wachmann 1 (SW1), a highly active, regularly outbursting Centaur. SW1's present-day, very-low-eccentricity orbit was established after a 1975 Jupiter conjunction and will persist until a 2038 Jupiter conjunction doubles its eccentricity and pushes its semimajor axis out to its current aphelion. Subsequent evolution will likely drive SW1's orbit out of the Gateway region, perhaps becoming one of the largest JFCs in recorded history. The JFC Gateway region coincides with a heliocentric distance range where the activity of observed cometary bodies increases significantly. SW1's activity may be typical of the early evolutionary processing experienced by most JFCs. Thus, the Gateway region, and its most notable occupant SW1, are critical to both the dynamical and physical transition between Centaurs and JFCs.
The Impact of Metallicity Evolution of the Universe on the Maximum Mass of LIGO Binary Black Holes
Authors: Safarzadeh Mohammadtaher , Farr Will M. 
Published: September 2019

Abstract
We can be biased against observing massive black holes (BHs) merging in the local universe as the bounds on the maximum BH mass (

) depends on the assumptions regarding the metallicity evolution of the star-forming gas across the cosmic time. We investigate the bounds on the metallicity evolution, mass distribution, and delay times of the binary BH sources based on the 10 observed events by LIGO. We parametrize

to be a function of metallicity that itself is modeled to evolve with redshift in either a modest or rapid fashion. Rapid metallicity evolution models predict a stringent bound of

, while the bound on

in the models with modest metallicity evolution is

. Therefore, inferring

from GW data depends on the assumed metal enrichment history of the universe that is not severely constrained at the moment.
The Changing Rotational Light-curve Amplitude of Varuna and Evidence for a Close-in Satellite
Authors: Fernández-Valenzuela Estela , Ortiz Jose Luis , Morales Nicolás , Santos-Sanz Pablo , Duffard René , Aznar Amadeo , Lorenzi Vania , Pinilla-Alonso Noemí , Lellouch Emmanuel 
Published: September 2019

Abstract
From CCD observations carried out with different telescopes, we present short-term photometric measurements of the large trans-Neptunian object Varuna in 10 epochs, spanning around 19 years. We observe that the amplitude of the rotational light curve has changed considerably during this period of time from 0.41 to 0.55 mag. In order to explain this variation, we constructed a model in which Varuna has a simple triaxial shape, assuming that the main effect comes from the change of the aspect angle as seen from Earth, due to Varuna’s orbital motion in the 19 year time span. The best fits to the data correspond to a family of solutions with axial ratios b/a between 0.56 and 0.60. This constrains the pole orientation in two different ranges of solutions presented here as maps. Apart from the remarkable variation of the amplitude, we have detected changes in the overall shape of the rotational light curve over shorter timescales. After the analysis of the periodogram of the residuals to a 6.343572 hr double-peaked rotational light-curve fit, we find a clear additional periodicity. We propose that these changes in the rotational light-curve shape are due to a large and close-in satellite whose rotation induces the additional periodicity. The peak-to-valley amplitude of this oscillation is in the order of 0.04 mag. We estimate that the satellite orbits Varuna with a period of 11.9819 hr (or 23.9638 hr), assuming that the satellite is tidally locked, at a distance of ∼1300 km (or ∼2000 km) from Varuna, outside the Roche limit.
Exploring the Local Black Hole Mass Function below 106 Solar Masses
Authors: Gallo Elena , Sesana Alberto 
Published: September 2019

Abstract
The local black hole mass function (BHMF) is of great interest to a variety of astrophysical problems, ranging from black hole binary merger rates to an indirect census of the dominant seeding mechanism of supermassive black holes. In this Letter, we combine the latest galaxy stellar mass function from the Galaxy And Mass Assembly survey with X-ray-based constraints to the local black hole occupation fraction to probe the BHMF below 106
M
⊙. Notwithstanding the large uncertainties inherent to the choice of a reliable observational proxy for black hole mass, the resulting range of BHMFs yields a combined normalization uncertainty of ≲1 dex over the [105–106] M
⊙ range, where upcoming, space-based gravitational wave detectors are designed to be most sensitive.
Correlation Between Optical Coherence Tomography and Magnetic Resonance Imaging of Rectus Muscle Thickness Measurements in Graves' Ophthalmopathy
Authors: De-Pablo-Gómez-de-Liaño Lucía , Fernández-Vigo José Ignacio , Merino-Menéndez Salomé , Duque-Muñoz María , Gómez-de-Liaño Rosario 
Published: September 2019

Purpose:
To assess the correlation between optical coherence tomography (OCT) and magnetic resonance imaging (MRI) measurements of extraocular rectus muscle thickness in patients with Graves' ophthalmopathy.

Methods:
This was a cross-sectional observational study conducted in 62 eyes of 31 patients with Graves' ophthalmopathy. The disease phase was inactive in 20 patients and active in the remaining 11. The OCT measurements obtained were: medial rectus thickness at 7.2 and 9.2 mm from the limbus and lateral rectus thickness at 8.5 mm from the limbus. MRI measurements were maximum transversal diameter (T-MRI), craniocaudal diameter (CC-MRI), and muscle area (A-MRI).

Results:

For the whole patient cohort, correlation emerged between the OCT-MR and T-MRI measurements (
R
= 0.428 to 0.576;
P
≤ .002), A-MRI (
R
= 0.562 to 0.674;
P
< .001), and CC-MRI (
R
= 0.286 to 0.293;
P
≤ .046). In patients with clinically active Graves' ophthalmopathy, correlations with T-MRI (
R
= 0.576 to 0.604;
P
≤ .010) and A-MRI (
R
= 0.678 to 0.706;
P
< .001) were higher. No correlations were detected between OCT and MRI measurements of lateral rectus thickness (
P
≥ .177), regardless of disease phase.

Conclusions:
The correlations observed suggest OCT could be a complementary assessment or screening method to detect thickening of the anterior portion of the medial rectus muscle in patients with Graves' ophthalmopathy, which may be especially useful when MRI is not available.

[
J Pediatr Ophthalmol Strabismus
. 2019;56(5):319–326.]
How Many Plusoptix S04 Measures Yield the Most Sensitive Amblyopia Screening?
Authors: Guimarães Sandra , Soares Andreia , Costa Patrício , Silva Eduardo 
Published: September 2019

Purpose:
To analyze how the Plusoptix S04 (Plusoptix, Atlanta, GA), a widely used technology for amblyopia screening, predicts amblyopia.

Methods:
A total of 1,547 children aged 3 to 4 years underwent a non-invasive eye examination in a whole population screening. The Plusoptix was measured binocularly three consecutive times. Seven models were developed: the first (P1), second (P2), and third (P3) measure of Plusoptix, the mean of P1, P2, and P3 (Pmean123), the maximal value of P1, P2, and P3 (Pmax123), the mean of P1 and P2 (Pmean12), and the maximal value of P1 and P2 (Pmax12).

Results:

Internal consistency was excellent for sphere, cylinder (alpha = 0.92 vs 0.97), aniso-sphere, and aniso-cylinder (alpha = 0.87 vs 0.86). All models predicted amblyopia (
P
< .001); there was 2.3% new diagnosis and 5.1 events per variable. A bootstrap analysis with 1,000 samples confirmed the stability of the model. Astigmatism (
P
< .001; odds ratio [OR] = 2.1 to 3.6) and aniso-sphere (
P
< .001; OR = 3.6 to 9.0) predicted amblyopia. Although sphere, when measurable, did not predict amblyopia (
P
> .19; OR = 1.2 to 1.3), the likelihood of amblyopia presence was 100 times higher when the Plusoptix displayed “hyper.” All receiver operating characteristic (ROC) curves were significant (
P
< .001), with no differences between them (all
P
> .16). Adjusting the cut-off from ROC curves for the highest sensitivity, Pmax12 referred 31.9% and 16.1% fewer patients than P1 and Pmean12, respectively. A third measure revealed accommodation-related false-negative results; therefore, adding measurements showed no benefit.

Conclusions:
This was the first study to assess the Plusoptix's prediction of amblyopia. When aiming for maximal sensitivity, the Plusoptix refers many children (> 20% children in all models). The first measure refers more children than two measures. Non-measurable results must be considered abnormal because the chance of amblyopia presence was high.

[
J Pediatr Ophthalmol Strabismus
. 2019;56(5):305–312.]
Long-Term Ophthalmic Outcomes in Pediatric Orbital Cellulitis: A Prospective, Multidisciplinary Study From a Tertiary-Care Referral Institute
Authors: Singh Manpreet , Negi Avinash , Zadeng Zoramthara , Verma Roshan , Gupta Pankaj 
Published: September 2019

Purpose:
To analyze the clinical profile, radiological features, and ophthalmic outcomes of the multidisciplinary management of children with pediatric orbital cellulitis.

Methods:
A prospective, interventional study of patients diagnosed as having pediatric orbital cellulitis was conducted. A complete history, clinical examination, laboratory work-up, radiology (computed tomography [CT]), multidisciplinary consultations (otolaryngology, pediatrics, and microbiology), and treatment plan were obtained for all children. The patients were admitted to the hospital and administered intravenous broad-spectrum antibiotics. Orbital and subperiosteal abscesses were drained via an endonasal or external route. Functional endoscopic sinus surgery was performed when necessary. After a minimum follow-up of 12 months, visual acuity, pupillary reaction, extraocular movements, and proptosis were evaluated as the outcome measures.

Results:
Forty patients (male = 28, 70%) had unilateral presentation of pediatric orbital cellulitis at a mean age of 7.5 years (range: 4 to 12 years). At presentation, all patients had eyelid edema, conjunctival congestion, and chemosis: 38 (95%) had proptosis, 36 (90%) had decreased extraocular movements and pain, 16 (40%) had a relative afferent pupillary defect, and 6 (15%) had exposure keratitis and optic disc edema. CT scans showed sinusitis in 30 (75%) patients, orbital abscess in 14 (35%) patients, and subperiosteal abscess in 5 (12.5%) patients. At a mean follow-up of 15 months, 30 (75%) patients had complete success, 8 (20%) patients had partial success, and the treatment failed in 2 (5%) patients. No patient had any life-threatening complications.

Conclusions:
The multidisciplinary management of pediatric orbital cellulitis provides satisfactory long-term ophthalmic outcomes. Ethmoidal sinusitis is the most common etiology of pediatric orbital cellulitis, and endoscopic abscess drainage and functional endoscopic sinus surgery are minimally invasive and provide rapid relief in children.

[
J Pediatr Ophthalmol Strabismus
. 2019;56(5):333–339.]
Accuracy of Corneal Elevation with Four Corneal Topography Systems
Authors: Schultze Robert L 
Published: September 2019

ABSTRACT
PURPOSE: To compare the elevation accuracy of placido-based videokeratoscopes with a rasterphotogrammetry-based topography system using models of an aspheric surface and a simulated myopic ablation.
METHODS: Test surfaces representative of normal corneas and corneas after excimer ablation were fabricated from a material measurable using both reflective (placido) and projective (rasterstereographic) systems. The "normal" surface was a rotationally symmetric asphere, while the simulated photorefractive keratectomy ablation had a central 5.5 mm diameter clear zone with a 1 mm blend radius to eliminate surface discontinuity. The surfaces were measured with their axes of symmetry aligned with the instrument axis, and again with their axes tilted downward by 10° to produce a nonsymmetric shape.
RESULTS: All of the topography systems performed reasonably well in measuring the aspheric surface, with root mean square elevation error ranging from 1.2 to 14.3 µ??. The rasterstereographic system had a root mean square error of 4.7 µ?\ on the simulated ablation, while the placido systems had root mean square errors of 10.6 to 29.5 µt?. Tilting the surfaces did not significantly alter the results.
CONCLUSIONS: The tested placido videokeratoscopes do not provide reliable elevation data for shapes that have nonlinear changes in curvature. This may have serious implications if these systems are used for postoperative analysis or contact lens fitting on corneas that have been modified by refractive procedures. [J Refract Surg 1998;14:100-104]
Robust point set registration method based on global structure and local constraints
Authors: Yang Kai , Chen Yufei , Zhang Haotian , Liu Xianhui , Zhao Weidong 
Published: September 2019

Background and Objectives:
Point set registration is a very fundamental problem in computer vision. The registration problem can be divided into rigid and nonrigid registration. The transformation function modeling of rigid registration is simpler, whereas the nonrigid registration is better to solve the practical problems.

Materials and Methods:
We proposed a robust point set registration method using both global and local structures. Here, we use a popular probability model, Gaussian mixture model, to preserve the global structure of point set. Then, we designed a local constraint provided by some neighboring points to maintain the local structure of the point set. Finally, expectation-maximization algorithm is used to update model parameters in our method.

Results:
First of all, we carried out experiments on the synthesized data, which included four degradation cases: deformation, noise, outlier, and rotation. By comparing the mean and standard deviation of registration errors with the several state-of-the-art methods, our method was proved to have stronger robustness. Then, we conducted experiments on real retinal fundus images, aiming to establish reliable feature point correspondence between the two images. The experimental results show that we perform better when the two images have larger shooting angles and more noises.

Conclusions:
The Gaussian mixture protects the global structure of the point set, and the local constraints make full use of the local structure, which makes our method more robust. Experiments on synthetic data prove that our method obtains superior results to those of the state-of-the-art methods. Experiments on retinal image data show that our method also performs very well in practical applications.
Local Gauss multiplicative components method for brain magnetic resonance image segmentation
Authors: Cheng Jie , Yin Haiqing , Jiang Lingling , Zheng Junyu , Wei Su 
Published: September 2019

Background and Objectives:
In magnetic resonance (MR) images’ quantitative analysis, there are often considerable difficulties due to factors, such as intensity inhomogeneities and low contrast. Here, we construct a new image segmentation method to solve the MR image segmentation problem caused by internal and external factors.

Materials and Methods:
We downloaded a series of MR images as research objects through the BrainWeb (http://www.bic.mni.mcgill.ca/brainweb/). There is low contrast information between different components in these images. In addition, we randomly added a certain degree of bias field information to the images. We proposed a model that can simultaneously perform bias field estimation and image segmentation. Our idea is to make use of the property that observed image can be decomposed into multiplicative components. First, the bias field representation is given by a series of smooth basic functions; the required true image is represented as the function of observed image and bias field. Then, the segmentation model of Gaussian probability distribution with different means and variances is constructed by local information.

Results:
Qualitative experiments (intensity inhomogeneity images) show that our model achieves satisfactory segmentation results with very few (<10) iterations for severe intensity inhomogeneities image segmentation, while quantitative experiments (20 brain MR images) show that the proposed model can achieve higher accuracy in segmentation.

Conclusions:
Different from the existing model, our model is constructed based on the local information of the true image, and the influence of above-mentioned factors is better avoided and obtain satisfactory results.