bluuebunny/crossref_metadata_2025_split huggingface dataset:
Parent experiences with genetic testing for pediatric hearing loss
Authors: Cejas Ivette , Coto Jennifer , Sarangoulis Christina M. , Yunis Valerie , Blanton Susan , Liu Xue Zhong 
Published: November 2024

AbstractThe purpose of the current study was to assess parent perceptions and experiences of genetic testing, as well as barriers for not undergoing testing in a sample of families of children with hearing loss. A 44‐item questionnaire, The Parent Perception of Genetic Testing Questionnaire developed by the research study team was administered. Participants were recruited from a pediatric otolaryngology/audiology practice and social media. A total of 146 parents of children with hearing loss participated. Approximately 47.6% of the children in our sample underwent genetic testing, 44.8% did not, and 7.6% of parents were unsure. For those that did not undergo testing, reasons included: unaware (6.2%), not interested (8.9%), cost (8.9%), time (3.4%), fearful of results (2.7%), and never offered (15.1%). For those that did undergo testing, over half of the parents reported that they did not receive counseling before (55.1%) and 41.7% reported they received counseling after the testing. Furthermore, parents were confused about the results with 18.3% reporting they were Very Confused, 28.3% Somewhat Confused, 20% A Little Confused, and 33.3% Not Confused at All about the variant of uncertain or unknown significance. Notably, less than half of parents (43.4%) remembered what they were told about the mode of inheritance. Overall, our study highlighted the low adoption rate of genetic testing and lack of integration into standard of care for otology/audiology practices. Collaboration between hearing healthcare professionals and geneticists is warranted to determine how to reduce barriers to access while improving pre‐ and post‐counseling.
The effect of symmetry‐preserving operations on 3‐connectivity
Authors: Van den Camp Heidi 
Published: November 2024

AbstractIn 2017, Brinkmann, Goetschalckx and Schein introduced a very general way of describing operations on embedded graphs that preserve all orientation‐preserving symmetries of the graph. This description includes all well‐known operations such as Dual, Truncation and Ambo. As these operations are applied locally, they are called local orientation‐preserving symmetry‐preserving operations (lopsp‐operations). In this text, we will use the general description of these operations to determine their effect on 3‐connectivity. Recently it was proved that all lopsp‐operations preserve 3‐connectivity of graphs that have face‐width at least three. We present a simple condition that characterises exactly which lopsp‐operations preserve 3‐connectivity for all embedded graphs, even for those with face‐width less than three.
High‐speed and contactless inspection of defective micro‐LEDs through the photovoltaic effect
Authors: Yasuda Toshiro , Sugawa Shigetoshi , Yokomichi Yayoi , Kobayashi Kazuhisa , Hamori Hiroshi , Teramoto Akinobu 
Published: November 2024

AbstractThe most significant challenge associated with micro‐light‐emitting‐diode (micro‐LED) displays, which are anticipated to be the next generation of display technology, is the high manufacturing cost. In order to reduce manufacturing costs, it is essential to improve yield. Improving the manufacturing yield of them necessitates the evaluation of micro‐LED chips prior to their installation onto substrates. However, the microsize and large quantity of these chips renders inspection difficult with conventional inspection methods. Herein, we propose a method for inspecting micro‐LED chips by measuring the voltage generated between the anode and cathode due to the photovoltaic effect using a developed proximity capacitance image sensor. As this inspection method does not require the use of probe pins to contact LED electrodes, it enables simultaneous inspection of multiple chips in a short time without causing any damage to the electrodes. In this paper, an experimental system equipped with this sensor was developed to demonstrate the basic measurement principle. Moreover, we demonstrated that more than 50,000 micro‐LED chips with a size of 60 μm × 34 μm can be simultaneously inspected in approximately 2 s.
How statistically fragile are randomized controlled trials comparing quadriceps tendon autografts with hamstring or bone‐patellar tendon‐bone autografts in anterior cruciate ligament reconstruction?
Authors: Dworsky‐Fried Joshua , Bernardini Luca , Vivekanantha Prushoth , Gyemi Lauren , Meena Amit , Tapasvi Sachin , Fink Christian , de SA Darren 
Published: November 2024

AbstractPurposeTo determine the statistical fragility of randomized controlled trials (RCTs) which compare the use of quadriceps tendon (QT) autografts to either hamstring tendon (HT) or bone‐patellar tendon‐bone (BPTB) autografts in anterior cruciate ligament reconstruction (ACLR).MethodsA search was conducted across PubMed, MEDLINE and EMBASE databases for RCTs comparing QT autografts to HT or BPTB autografts in ACLR from inception to 21 April 2024. Studies that reported ≥1 statistically significant continuous outcome, statistically significant dichotomous outcome and/or nonsignificant dichotomous outcome were included for analysis. The fragility index (FI), continuous fragility index (CFI) and reverse fragility index (RFI) were calculated for significant dichotomous outcomes, significant continuous outcomes and nonsignificant dichotomous outcomes, respectively.ResultsA total of 11 RCTs comprising 716 patients were included. The mean sample size was 65.8 patients. The median FI among nine outcomes from four studies was 1.0 (interquartile range [IQR], 0.5; 95% confidence interval [CI], 0.6–1.4; range 0.5–1.5). The number of patients lost to follow‐up at the final follow‐up period was more than the study‐specific FI in three (75%) studies. The median CFI among 30 outcomes from six studies was 4.9 (IQR, 10.1, 95% CI, 3.9–8.2; range 0–18.2). The number of patients lost to follow‐up at the final follow‐up period was more than the study‐specific CFI in four (66.7%) studies. The median RFI among 10 outcomes from five studies was 5.0 (IQR, 3.5; 95% CI, 3.4–6.6; range 1.0–9.0). The number of patients lost to follow‐up at the final follow‐up period was more than the study‐specific RFI in four (80%) studies.ConclusionThis systematic review revealed that regardless of the metric used, RCTs comparing QT autografts to HT or BPTB autograft options in ACLR are statistically fragile. While the indices of statistical fragility evaluated in this study are important metrics of robustness to consider, their application in research and clinical practice needs to be further elucidated.Level of EvidenceLevel I.
Linked Flaps of the Thoracodorsal Vascular Tree for Correcting Extensive Post‐Burn Deformities and Achieving Optimal Reconstruction Outcomes
Authors: Ryoo Hyun Jung , Park Ji Hwan , Park Ji Ah. , Kim Youn Hwan , Shim Hyung‐Sup 
Published: November 2024

ABSTRACTBackgroundAutologous skin grafting has been the popular method for reconstructing post‐burn defects. However, this technique has limitations such as high contracture rates and inadequate volume coverage. This report aims to propose the principles and advantages of utilizing microsurgically linked perforator flaps for the reconstruction of extensive burn defects and associated post‐burn scar contracture in the lower and upper extremities and trunk.MethodPatients who underwent free tissue transfer for primary and secondary burn wound reconstruction at a single institution between 2016 and 2023 were included in the study. Patients received thoracodorsal vascular tree‐linked flaps for the correction of post‐burn deformities. Postoperative results were evaluated, including flap survival, complications, and the DASH self‐report questionnaire for upper extremity reconstruction.ResultAmong the 20 patients, 12 required primary reconstruction, while 8 underwent secondary reconstruction using anastomotic chimeric free tissue transfer. The majority of burn injuries resulted from thermal contact (n = 8), followed by flames (n = 5), scalds (n = 4), electrical contact (n = 2), and friction (n = 1). The most frequently utilized combinations were the thoracodorsal artery perforator (TDAp) and anterolateral thigh (ALT) flap (11 cases). Additionally, four cases involved the pedicled TDAp flap in conjunction with the deep inferior epigastric artery perforator (DIEP) flap. The average DASH score for upper extremity burn patients was 10.58.ConclusionsThree‐dimensional tissue coverage achieved through the linkage of two or even three independent free flaps is increasingly utilized in post‐burn reconstruction. This approach offers multiple advantages and represents a viable option for burn reconstruction.
Diagnosis of incipient faults in wind turbine bearings based on ICEEMDAN–IMCKD
Authors: Li Yanjun , Han Ding 
Published: November 2024

AbstractTo address the difficulty in extracting early fault feature signals of rolling bearings, this paper proposes a novel weak fault diagnosis method for rolling bearings. This method combines the Improved Complementary Ensemble Empirical Mode Decomposition with Adaptive Noise (ICEEMDAN) and the Improved Maximum Correlated Kurtosis Deconvolution (IMCKD). Utilizing the kurtosis criterion, the intrinsic mode functions obtained through ICEEMDAN are reconstructed and denoised using IMCKD, which significantly reduces noise in the measured signal. This approach maximizes the energy amplitude at the fault characteristic frequency, facilitating fault feature identification. Experimental studies on two test benches demonstrate that this method effectively reduces noise interference and highlights the fault frequency components. Compared with traditional methods, it significantly improves the signal‐to‐noise ratio and more accurately identifies fault features, meeting the requirements for discriminating rolling bearing faults. The method proposed in this study was applied to the measured vibration signals of the gearbox bearings in the new high‐speed wire department of a Long Products Mill. It successfully extracted weak characteristic information of early bearing faults, achieving the expected diagnostic results. This further validates the effectiveness of the ICEEMDAN–IMCKD method in practical engineering applications, demonstrating significant engineering value for detecting and extracting weak impact characteristics in rolling bearings.
Optimal Bundling Cooperation Strategies for Online Paid Membership Programs
Authors: Du Shaofu , Li Zongyin , Choi Tsan‐Ming , Hu Li 
Published: November 2024

ABSTRACTPaid membership programs are popular in Internet firms, and “bundling cooperation for paid memberships” is trendy in their online operations. Unlike traditional product bundling problems, membership bundling between Internet firms presents new characteristics such as member sharing, which brings challenges to profit allocation and partner selection. Despite being a commonly seen business practice, little is known about the optimal bundling strategies and the cooperation mechanisms regarding firms' membership status. To fill this gap, we develop a stylized model that considers the potential added‐value income of membership to analyze the bundling problem between two firms. We show that the optimal bundling strategy depends on firms' original member bases and their ability to mine member value (i.e., value‐monetization ability). We discuss the allocation policy with Nash bargaining and find that the firm may entirely waive its bundled membership fee income and even compensate its partner to achieve cooperation. Surprisingly, a start‐up partner with no member base may be the optimal option. Nevertheless, if there is no such a partner in the market, forming a bundle with a well‐established partner is the right choice. Our findings provide novel managerial insights into bundled membership operations of Internet firms in practice.
The association of higher offspring early‐childhood weight gain with prepregnancy metabolic and bariatric surgery
Authors: Hilaire Maya‐Jean , Babcock Annelise , White Glenn , Masson Cynthia F. , Salem Rany M. , Reddy Uma M. , Gallagher Dympna , LeDuc Charles A. , Thaker Vidhu V. 
Published: November 2024

AbstractObjectiveThe objective of this study was to assess maternal gestational outcomes and offspring growth trajectories following prepregnancy metabolic and bariatric surgery (MBS) compared with non‐MBS controls.MethodsSingle‐center deliveries between January 2020 and March 2023 with prepregnancy Roux‐en‐Y gastric bypass (herein referred to as “bypass”), sleeve gastrectomy (herein referred to as “sleeve”), and non‐MBS controls were included. Offspring growth trajectories were compared with the World Health Organization child growth standards. Linear mixed models assessed MBS‐bypass and MBS‐sleeve offspring weight, length, and BMI trajectories with a prepregnancy BMI 27 to 37 kg/m2 and propensity score‐matched controls.ResultsThe study included 440 participants with prepregnancy MBS (MBS‐bypass, 185; MBS‐sleeve, 225; 76% Hispanic/Latino) and 13,434 non‐MBS controls. Gestational weight gain and gestational diabetes mellitus were similar, whereas hypertensive disorders of pregnancy were more common after MBS. The post‐MBS offspring had lower birth weight but higher weight gain at 24 months (sleeve, +1.4 kg [95% CI: 1.0–1.9]; bypass, +0.5–0.7 kg [95% CI: 0.0–1.2]) compared with non‐MBS groups. Male children had higher weight gain than females. The post‐MBS‐sleeve but not the post‐MBS‐bypass offspring had higher BMI z scores.ConclusionsThe higher early‐life weight gain and sex differences in the post‐MBS‐sleeve group compared with the post‐MBS‐bypass group provide a window toward elucidating pathways to mitigate intergenerational metabolic risk transfer.image
Electrospun Polylactic Acid/Polyethylene Glycol/ Silicate‐Chlorinated Bioactive Glass Composite Scaffolds for Potential Bone Regeneration
Authors: Souza Joyce R. de , Kukulka Elisa C. , Kito Letícia T. , de Sá Alves Mariana , dos Santos Verônica R. , Trichês Eliandra S. , Vasconcellos Luana M. R. , Thim Gilmar P. , Campos Tiago M. B. , Borges Alexandre L. S. 
Published: November 2024

ABSTRACTThe integration of bioglass with polymers in tissue engineering scaffolds holds promise for enhancing bone regeneration. This study explores the fabrication and characterization of composite scaffolds comprising polylactic acid (PLA)/polyethylene glycol (PEG) fibers incorporated with silicate‐chlorinated bioglasses (45S5 and 58S). Electrospinning was utilized to produce the scaffolds, followed by physical–chemical and in vitro evaluations. Scanning electron microscopy (SEM) revealed uniform fiber formation, with bioglass incorporation observed in the composite groups. Bioglass incorporation led to a significant reduction in fiber diameter. Thermogravimetric analysis (TGA) estimated bioglass content, with 58S exhibiting the highest incorporation. Contact angle measurements indicated enhanced hydrophilicity in bioglass‐containing groups. In vitro, bioactivity assessment in simulated body fluid (SBF) demonstrated apatite formation potential and the pH variance indicates a slightly alkaline to neutral condition. Cell culture studies revealed robust cellular adhesion and metabolic activity across all groups, with no cytotoxic effects observed. Overall, these findings suggest the potential of PLA/PEG bioglass composite scaffolds for bone tissue engineering applications.
Effect of multi‐angle lamination on mechanical properties and damages behavior of carbon fiber reinforced resin matrix composites
Authors: Huang Zhiquan , Zhang Liangliang , Zheng Yonglin , Zou Jinchao , Gao Xiangyu , Wang Tao 
Published: November 2024

AbstractCarbon fiber reinforced resin matrix composites, when subjected to multi‐angle delamination during vacuum hot pressing, suffered from defects such as uneven fiber distribution, resin‐rich zones, and voids. These defects caused varied damage and failure behaviors in the composites, seriously affecting their mechanical properties. In this paper, the defect distribution, tensile and flexural properties, and damage behaviors of multi‐angle lay‐up specimens prepared in an autoclave were studied. The results indicated that irregularly shaped voids in laminates with a 0° angle difference primarily led to local stress concentration. Elliptical and elongated voids in laminates with a 90° angle difference were mainly susceptible to delamination. The [0/90]8 layer exhibited the best overall mechanical properties. The proportion of 0° laminates had a direct impact on the mechanical properties, with 0° contact laminates on the bending‐compression side capable of withstanding higher bending loads. The [+45/−45]8 plyer demonstrated pseudo‐delayed behavior, enabling the laminate to show better toughness under load. Variations in damage due to the proportions and positions of the laminates influenced the mechanical properties and damages behavior of multi‐angle laminates.Highlights
Angular differences were observed to affect void and resin distribution.
The best overall mechanical properties were attributed to [0/90]8 laminates.
Pseudo‐delay behavior was exhibited by [+45/−45]8 laminates.
Proportion of 0° layers impacted mechanical properties.
Greater bending loads were withstood by the 0° contact layer.
A Horizontal Double‐Sided Copper Metallization Technology Designed for Solar Cell Mass‐Production
Authors: Wang Lu , Qin Yusen , Peng Meilin , Huang Meixian , Liu ZhiPeng , Lu Yibo , Zhou Guohua , Ji Jingjia 
Published: November 2024

ABSTRACTIn the international photovoltaic market, the “carbon footprint” label has received great attention, and low‐carbon footprint products are widely popular. Compared with metallic silver, copper has the characteristics of low carbon emissions and low cost, which can effectively reduce the carbon footprint. Based on this, this article reports a horizontal double‐sided copper metallization technology. This technology can not only metalize the front and back sides of various types of silicon solar cells at the same time but also has fast speed, good uniformity, and simple process, making it suitable for the industrial mass production of solar cells. This article describes the structure and manufacturing process of TOPCon solar cells patterned with an ultrashort pulse laser and metalized using this novel horizontal double‐sided copper metallization technology. In this batch, average efficiency reached above 26%.
Synthesis and Application of Biodegradable Cellulose Hydrogels From Sunflower Husks as a Water‐Retaining Material in Agriculture
Authors: Battalova Ainur , Kabdrakhmanova Sana , Akatan Kydyrmolla , Shaimardan Esbol , Beisebekov Madiar , Karzhaubayeva Aktoty , Kantay Nurgamit , Ibraeva Zhanar , Thomas Sabu 
Published: November 2024

ABSTRACTThe water shortage is currently a major problem for agriculture around the world, and this, in turn, can negatively impact food safety. Therefore, in this article, acrylamide monomer (AAm) was bound by the cross‐linking agent N, N′‐methylene‐bis‐acrylamide (MBA) in amounts of 10, 15, and 20 mg along with microcrystalline cellulose (MCC) obtained from sunflower seed husk (SFH) and a biodegradable hydrogel in the soil layer with high sorption capacity was synthesized. As a result of the study, the AAm monomer found to be attached to the MCC matrix via intermolecular hydrogen bonds. The kinetics of swelling of the obtained hydrogels in aqueous, electrolytic and water‐ethanol, water‐acetone binary solutions at various amounts of cross‐linking agent were comparatively studied, and it was found that the water sorption potential of the natural polymer—MCC‐based hydrogel (MCC hydrogel)—is high at pH = 6.5 and corresponds to the pH of the soil environment. The study showed that the synthesized hydrogel is optimal when using 10 mg of a cross‐linking agent, has mechanical strength, withstands pressure up to 27 MPa, completely decomposes at 796°C, and has good thermal stability. It has been established that the pore sizes of hydrogel with 10 mg of cross‐linking agent lie within the range of 313.9 nm‐den 3.41 μm and belong to mesoporous materials, where the degree of swelling is 1176%. The MCC hydrogel was saturated with water from the soil within 5 days and collapsed within 35 days, releasing the absorbed water back into the soil, losing 66% of its mass and undergoing biological decomposition. These properties of MCC hydrogel allow it to be used as a “water‐retaining material” in agriculture.
Global sensitivity analysis of Open Systems Pharmacology Suite physiologically based pharmacokinetic models
Authors: Najjar Abdulkarim , Hamadeh Abdullah , Krause Sophia , Schepky Andreas , Edginton Andrea 
Published: November 2024

AbstractSensitivity analyses are important components of physiologically based pharmacokinetic (PBPK) model development and are required by regulatory agencies for PBPK submissions. They assess the impact of parametric uncertainty and variability on model estimates, aid model optimization by identifying parameters requiring calibration, and enable the testing of assumptions within PBPK models. One‐at‐a‐time (OAT) sensitivity analyses quantify the impact on a model output in response to changes in a single parameter while holding others fixed. Global sensitivity analysis (GSA) methods provide more comprehensive assessments by accounting for changes in all uncertain or variable parameters, though at a higher computational cost. This tutorial article presents a software package for conducting both OAT and GSA of PBPK models built in the Open Systems Pharmacology (OSP) Suite. The tool is accessible through either an R script or a graphical user interface, and the outputs consist of sensitivity metrics of pharmacokinetic (PK) parameters, such as Cmax and AUC, evaluated with respect to model input parameters. Results are formatted according to regulatory standards. The OAT analysis methods comprise two‐way local sensitivity analyses and probabilistic uncertainty analyses, whereas the GSA methods include the Morris, Sobol, and EFAST methods. These analyses can be conducted on single PBPK models or pairs of models for the evaluation of the sensitivity of PK parameter ratios in drug–drug interaction studies. The practical application of the package is demonstrated through three illustrative case studies.