bluuebunny/crossref_metadata_2025_split huggingface dataset:
High prevalence and diversity of Extended-Spectrum β-Lactamase and emergence of Carbapenemase producingEnterobacteriaceaespp in wildlife in Catalonia
Authors: Darwich Laila , Vidal Anna , Seminati Chiara , Albamonte Andreu , Casado Alba , López Ferrán , Molina-López Rafael A. , Migura-Garcia Lourdes 
Published: January 2019

AbstractIn wildlife, most of the studies focused on antimicrobial resistance (AMR) describeEscherichia colias the principal indicator of the selective pressure. In the present study, new species ofEnterobacteriaceaewith a large panel of cephalosporin resistant (CR) genes have been isolated from wildlife in Catalonia. A total of 307 wild animals were examined to determine CR enterobacteria prevalence, AMR phenotypes and common carbapenem and CR gene expression. The overall prevalence of CR-phenotype was 13% (40/307): 17.3% in wild mammals (18/104) and 11.5% in wild birds (22/191) (p<0.01)). Hedgehogs presented the largest prevalence with 13.5% (14/104) of the mammal specimens, followed by raptors with 7.3% (14/191) of the total bird specimens. Although CRE. coliwas obtained most frequently (45%), other CR-Enterobacteriaceaespp likeKlebsiella pneumoniae(20%),Citrobacter freundii(15%),Enterobacter cloacae(5%),Proteus mirabilis(5%),Providenciaspp (5%) andSerratia marcescens(2.5%) were isolated. A high diversity of CR genes was identified among the isolates, with 50% yieldingblaCMY-2, 23%blaSHV-12, 20%blaCMY-1 and 18%blaCTX-M-15. Additionally, new CR-gene variants and resistance to carbapenems associated to OXA-48 were found. Most of the CR isolates, principallyK. pneumoniaeandC. freundii, were multiresistant with co-resistance to fluoroquinolones, tetracycline, sulphonamides and aminoglycosides. This study describes for the first time in wildlife a high prevalence ofEnterobacteriaceaespp harbouring a large variety of carbapenem and CR genes frequently associated to nosocomial human infections. Implementation of control measures to reduce the impact of anthropogenic pressure in the environment is urgently needed.
Structure-Unbinding Kinetics Relationship of p38α MAPK Inhibitors
Authors: Ge Xiaoxia , Tan Hepan , Xie Lei 
Published: January 2019

AbstractRational Drug Design still faces a major hurdle for the prediction of drug efficacyin vivosolely based on its binding affinity for the targetin vitro. The traditional perspective has proven to be inadequate as it lacks the consideration of essential aspects such as pharmacokinetics and binding kinetics in determining drug efficacy and toxicity. Residence time, the average lifetime of drug-target complex, has gained broader recognition as a better predictor for lead optimization. Long residence time could contribute to sustained pharmacological effect and may mitigate off-target toxicity as well. To unravel the underlining mechanism for variation of residence time and determine the ligand features governing the unbinding kinetics, unbinding kinetics of two distinct type II inhibitors of p38α MAP kinase were investigated and compared by molecular dynamics and metadynamics simulation approaches. Free energy landscape of key motions associated with unbinding was constructed for both inhibitors. Multiple unbinding pathways and rebinding were revealed during the drug-target dissociation process of faster unbinder Lig3 and slower unbinder Lig8 respectively, suggesting a novel mechanism of unbinding kinetics. This comparative study implies that hydrophobic and hydrogen-bonding interactions in the R1 group of ligands are crucial for slow unbinding. Such kind of structure-kinetics relationship approaches could also be applied to predict unbinding pathways and kinetics of many other small molecules, and facilitate the design of efficient kinase inhibitors.
An information system architecture for ensuring anonymity of student survey responses
Authors: Ardalan Alireza , Ardalan Roya K. , Rao Shailaja , Alexander Kay B. 
Published: January 2019

Purpose
There has been a lack of an information systems architecture which explicitly illustrates processes that make and maintain the anonymity of student responses in an online system for student opinion survey of faculty teaching. The purpose of this paper is to present an information systems architecture which explicitly shows the process of disassociation of student credentials and their responses. It also shows that the process guarantees a complete anonymity of student responses.

Design/methodology/approach
The system was developed to satisfy the needs of students, faculty and administrators of a higher education institution with several objectives, one of which is the complete anonymity of student responses.

Findings
The system developers were successful in designing and developing a student opinion survey system that keeps student responses completely anonymous.

Research limitations/implications
The anonymity of student responses improves students’ trust in the survey system and may increase student response rate. Other factors that affect student response rate should be analyzed to determine their effect on student response rate and adjust those factors to improve student response rate.

Practical implications
This paper shares the success of developing an information system that makes student responses anonymous. The goal is to increase the discussion of this topic among researchers and practitioners to further improve the system to increase student response rate.

Originality/value
The proposed information system architecture is novel because it keeps student responses completely anonymous.
Design and performance analysis of an industrial robot arm for robotic drilling process
Authors: Sun Longfei , Liang Fengyong , Fang Lijin 
Published: January 2019

Purpose
The purpose of this paper is to present a robotic arm that can offer better stiffness than traditional industrial robots for improving the quality of holes in robotic drilling process.

Design/methodology/approach
The paper introduces a five-degree of freedom (DOF) robot, which consists of a waist, a big arm, a small arm and a wrist. The robotic wrist is composed of two DOFs of pitching and tilting. A parallelogram frame is used for robotic arms, and the arm is driven by a linear electric cylinder in the diagonal direction. Double screw nuts with preload are used in the ball screw to remove the reverse backlash. In addition, dual-motor drive is applied for each DOF in the waist and the wrist to apply anti-backlash control method for eliminating gear backlash.

Findings
The proposed robotic arm has the potential for improving robot stiffness because of its truss structure. The robot can offer better stiffness than industrial robots, which is beneficial to improve the quality of robotic drilling holes.

Originality/value
This paper includes the design of a five-DOF robot for robotic drilling tasks, and the stiffness modeling of the robot is presented and verified by the experiment. The robotic system can be used instead of traditional industrial robots for improving the hole quality to a certain extent.
Market distance and insider-ownership strategies: a resource-dependence perspective
Authors: Lin Wen-Ting 
Published: January 2019

PurposeOwnership issues are an important feature of corporate governance when firms focus on global expansion in multiple and diverse regions. Drawing on resource dependence theory (RDT), the purpose of this paper is to address the phenomenon regarding the extent to which international market distance affects equity stakes in group-affiliated firms held by business group headquarters.Design/methodology/approachThis study uses longitudinal data on foreign direct investments by 106 business groups (BGs), including 561 group-affiliated firms, from Taiwan over a five-year period from 2006 to 2010.FindingsThe results show that the equity stakes of the BG headquarters in the group-affiliated firms in foreign markets were positively associated with the geographic distance between the country of the BG headquarters and the host country of the foreign group-affiliated firms, the cultural distance between the country of the BG headquarters and the host country of the foreign group-affiliated firms and institutional distance between the country of the BG headquarters and the host country of the foreign group-affiliated firms.Research limitations/implicationsMost studies of corporate governance and international business are based on a transaction cost economics approach, a resource-based perspective and agency and institutional theories. In contrast, this study, by using RDT, provides an alternative explanation regarding the factors that affect the equity stakes of parent firms in group-affiliated firms.Practical implicationsThis study presents two basic pieces of advice for consideration. First, at the managerial level, group-affiliated firms should develop their own resources and capabilities in order to become more autonomous in pursuing advantageous international activities that the parent firms may not foresee. Second, and again at the managerial level, business group headquarters should adopt a strategy to balance the dependency relationship between group-affiliated firms and business group headquarters.Originality/valueThis study provides the most finely grained analysis, to date, regarding how international market distance affects business group headquarters from newly industrialized economies in terms of diverse equity stakes in foreign affiliates, the unique attributes of BGs and international market distances’ relationship with both the operations and the expansion opportunities of BGs.
Drivers and barriers to circular economy implementation
Authors: Agyemang Martin , Kusi-Sarpong Simonov , Khan Sharfuddin Ahmed , Mani Venkatesh , Rehman Syed Tahaur , Kusi-Sarpong Horsten 
Published: January 2019

Purpose
Circular economy (CE) has gained considerable attention from researchers and practitioners over the past few years because of its potential social and environmental benefits. However, limited attention has been given in the literature to explore the drivers and barriers in CE implementation in emerging and developing countries besides China. Therefore, the purpose of this paper is to identify the drivers and barriers to implementing a CE in Pakistan’s automobile manufacturing industry.

Design/methodology/approach
This study adopts an explorative approach to understand the drivers and barriers at the micro-level CE implementation in Pakistan’s automobile industry. The research design includes both qualitative and quantitative methods using a survey instrument and interviews to gather data. The use of the two main sources of data provides the opportunity for triangulation of the data to improve the validity of the findings, and enables greater inferences from the results.

Findings
This study shows that “profitability/market share/benefit” (30 percent), “cost reduction” (22 percent) and “business principle/concern for environment/appreciation” (19 percent) are the top three drivers. Similarly, “unawareness” (22 percent), “cost and financial constraint” (20 percent) and “lack of expertise” (17 percent) are the top three barriers in implementing CE principles in Pakistan automobiles industry.

Research limitations/implications
This study considers only Pakistan automobiles industry, and the practical implications potentially limit to emerging Asian economies.

Originality/value
This study is the first of its kind that has investigated the drivers and barriers of CE at the organizational level in the automobile industry of Pakistan. Thus, it helps to advance the understanding of the subject matter and enables the formulation of effective policies and business strategies by practitioners for upscaling CE and sustainability.
Prognostic significance of basal versus superior segment in patients with completely resected lung adenocarcinoma in the lower lobe
Authors: Lin Yi‐Han , Hung Jung‐Jyh , Yeh Yi‐Chen , Hsu Wen‐Hu 
Published: January 2019

BackgroundAlthough the lower lobes of the lungs occupy half of the chest on both sides, the prognostic value of tumor location in lung cancer in the lower lobe has not been well demonstrated. This study investigated the prognostic value of tumor location (basal vs. superior) in patients with resected lung adenocarcinoma in the lower lobe.MethodsA total of 207 patients undergoing lobectomy for lung adenocarcinoma in the lower lobe were included in the study. The association between tumor location and mediastinal lymph node metastasis was analyzed. Prognostic factors of overall survival and probability of freedom from recurrence (FFR) were also investigated.ResultsDuring follow‐up, 71 (34.3%) patients developed recurrence. Patients with basal segment tumors had a significantly higher possibility of developing N2 lymph node metastasis than those with superior segment tumors (P = 0.025). Univariate analysis showed that location in the basal (vs. superior) segment was a significant prognostic factor for a lower probability of FFR (P = 0.013). Basal (vs. superior) segment remained a significant prognostic factor for a lower probability of FFR (P = 0.010) in multivariate analysis.ConclusionsBasal segment tumors have a significantly higher possibility of developing N2 lymph node metastasis than superior segment tumors in resected lung adenocarcinoma in the lower lobe. Tumor location at the basal segment was a significant prognostic factor for a lower probability of FFR. This information is useful for patient stratification of risk of postoperative recurrence.
Urban Political Ecology from Below: Producing a “Peoples’ History” of the Portland Harbor
Authors: Goodling Erin 
Published: January 2019

AbstractUrban political ecology scholars recognise that a historical perspective is central to elucidating processes of racialised uneven development. In this paper, I articulate a collectively produced “peoples’ history” of the Portland Harbor Superfund Site, recounting how over a century of industrial pollution in Portland, Oregon has disproportionately impacted Native, Black, immigrant and refugee, and houseless residents of all backgrounds—and has spawned collective work for a more just future. I argue that it is imperative for scholars to not only articulate such racialised pasts, however, but also to recognise how those working on the front lines of change draw on their own personal and group experiences to produce shared narratives, particularly across difference and in a context of depoliticised, ahistorical sustainability discourse. The case of the Portland Harbor Community Coalition reveals how the production of a shared history can be an important part of work to redress racialised dispossession and displacement in so‐called green cities.
The impact of bilingual environments on selective attention in infancy
Authors: Comishen Kyle J. , Bialystok Ellen , Adler Scott A. 
Published: January 2019

AbstractBilingualism has been observed to influence cognitive processing across the lifespan but whether bilingual environments have an effect on selective attention and attention strategies in infancy remains an unresolved question. In Study 1, infants exposed to monolingual or bilingual environments participated in an eye‐tracking cueing task in which they saw centrally presented stimuli followed by a target appearing on either the left or right side of the screen. Halfway through the trials, the central stimuli reliably predicted targets' locations. In Study 2, the first half of the trials consisted of centrally presented cues that predicted targets' locations; in the second half, the cue–target location relation switched. All infants performed similarly in Study 1, but in Study 2 infants raised in bilingual, but not monolingual, environments were able to successfully update their expectations by making more correct anticipatory eye movements to the target and expressing faster reactive eye latencies toward the target in the post‐switch condition. The experience of attending to a complex environment in which infants simultaneously process and contrast two languages may account for why infants raised in bilingual environments have greater attentional control than those raised in monolingual environments.
Impaired left ventricular mechanics and functional reserve are associated with reduced exercise capacity in patients with hypertrophic cardiomyopathy
Authors: Wu Xiao‐Peng , Li Yi‐Dan , Zhang Miao , Zhu Wei‐Wei , Cai Qi‐Zhe , Jiang Wei , Sun Lan‐Lan , Ding Xue‐Yan , Ye Xiao‐Guang , Qin Yun‐Yun , Lu Xiu‐Zhang 
Published: January 2019

BackgroundReduced metabolic equivalents (METs) are an indicator of exercise intolerance, which predicts poor prognosis in hypertrophic cardiomyopathy (HCM) patients. We sought to evaluate the changes in left ventricular (LV) mechanics and functional reserves, as well as their association with functional capacity in HCM patients.MethodsSeventy HCM patients and thirty controls were included in this study. LV mechanics were evaluated at rest and during exercise by echocardiography and two‐dimensional speckle‐tracking imaging to obtain parameters of functional reserve, LV global longitudinal strain (LVGLS), strain rate (SR), and circumferential strain.ResultsHypertrophic cardiomyopathy (HCM) patients had lower LVGLS, systolic SR, early and late diastolic SR at rest and during exercise, and reduced absolute and relative systolic and diastolic reserve compared to controls. LV circumferential strain was significantly higher at rest but lower during exercise in HCM patients. Exercise capacity was markedly reduced in HCM patients, and peak exercise LVGLS (LVGLS‐exe) significantly correlated with exercise capacity. Multivariate regression analyses showed that LVGLS‐exe, LV filling pressure during exercise (E/e'‐exe), and LV mass index (LVMI) were independent predictors of exercise capacity. Moreover, LVGLS‐exe displayed incremental predictive value over E/e'‐exe and LVMI for exercise intolerance. Receiver operating characteristic curve analysis showed LVGLS‐exe had optimal accuracy for predicting exercise intolerance in HCM patients.ConclusionsHypertrophic cardiomyopathy (HCM) patients have reduced LV mechanics at rest and during exercise and impaired mechanical reserve. LVGLS‐exe is associated with exercise capacity and is an optimal predictive value for reduced exercise capacity in HCM patients.
LIMD1 phosphorylation in mitosis is required for mitotic progression and its tumor‐suppressing activity
Authors: Zhou Jiuli , Zhang Lin , Zhou Wei , Chen Yuanhong , Cheng Yufeng , Dong Jixin 
Published: January 2019

LIM domains containing 1 (LIMD1) is a member of the Zyxin family proteins and functions as a tumor suppressor in lung cancer. LIMD1 has been shown to regulate Hippo‐YAP signaling activity. Here, we report a novel regulatory mechanism for LIMD1. We found that cyclin‐dependent kinase 1 (CDK1) and c‐Jun NH2‐terminal kinases 1/2 (JNK1/2) phosphorylate LIMD1 in vitro and in cells during anti‐tubulin drug‐induced mitotic arrest. Phosphorylation also occurs during normal mitosis. S272, S277, S421, and S424 were identified as the main phosphorylation sites in LIMD1. Deletion of LIMD1 resulted in a shortened mitotic cell cycle and phosphorylation of LIMD1 is required for proper mitotic progression. We further showed that the phosphorylation‐deficient mutant LIMD1‐4A is less active in suppressing cell proliferation, anchorage‐independent growth, cell migration, and invasion in lung cancer cells. Together, our findings suggest that LIMD1 is a key regulator of mitotic progression, and that dysregulation of LIMD1 contributes to tumorigenesis.
Stress intensity factors for circumferential through‐wall cracks in thin‐walled cylindrical shells subjected to tension and torsion
Authors: Rege Kristen , Pavlou Dimitrios G. 
Published: January 2019

AbstractIn order to assess the structural integrity of tubular members or pipes containing circumferential through‐wall cracks, their stress intensity factor solutions are required. While stress intensity factors for tension and bending are available, few solutions exist for the case of torsion, even though these components may also be subjected to torque. In this paper, the finite element method is used to compute the stress intensity factors for this geometry under tension and torsion. Shell elements are employed to compute the results for thin shells by the means of the displacement extrapolation technique. The computed results indicate that the available analytical solution for torsional loading, which is based on shallow shell theory, is nonconservative for long cracks in thin shells. Shallow shell theory is in general not applicable to long cracks, and the present work is therefore able to provide solutions for a wider range of crack lengths than what is currently available.
Analysis of the stress intensity factor dependence with the crack velocity using a lattice model
Authors: Braun Matías , González Albuixech Vicente Francisco 
Published: January 2019

AbstractIn this work, the influence of crack propagation velocity in the stress intensity factor has been studied. The analysis is performed with a lattice method and a linear elastic constitutive model. Numerous researchers determined the relationship between the dynamic stress intensity factor and crack propagation velocity with experimental and analytical results. They showed that toughness increases asymptotically when the crack tip velocity is near to a critical. However, these methods are very complex and computationally expensive; furthermore, the model requires the use of several parameters that are not easily obtained. Moreover, its practical implementation is not always feasible. Hence, it is usually omitted. This paper aims to capture the physics of this complex problem with a simple fracture criterion. The selected criterion is based on the maximum principal strain implemented in a lattice model. The method used to calculate the stress intensity factor is validated with other numerical methods. The selected example is a finite 2D notched under mode I fracture and different loads rates. Results show that the proposed model captures the asymptotic behaviour of the SIF in function of crack speed, as reported in the aforementioned models.
When two worlds collude: Working from home and family functioning in Australia
Authors: DOCKERY Alfred M. , BAWA Sherry 
Published: January 2019

AbstractThis article analyses the effect of employees working from home on their partners' assessments of family functioning using Australian household panel data collected from 2001 to 2013 in 48 multivariate models. Some evidence is found that working from home contributes to better relationships and a more equitable division of household responsibilities for couples with children. Limited evidence of negative externalities is observed, notably where male employees work substantial hours from home. Overall the findings contribute to the weight of evidence that working from home is conducive to families achieving a better work‐life balance.
Gendered costs of austerity: The effects of welfare regime and government policies on employment across the OECD, 2000–13
Authors: KUSHI Sidita , McMANUS Ian P. 
Published: January 2019

AbstractThis article proposes a thorough analysis of the gendered impact of government policies applied during the Great Recession on unemployment across 28 OECD countries following an empirical estimation using random effects modelling with data from 2000 to 2013 to test the influence of welfare systems. Results point to a significant effect of welfare regime even beyond the crisis, primarily through social expenditure levels and public sector employment dynamics, which mainly affect women. The detailed policy analysis highlights the need to look for alternatives to austerity policies, and the authors conclude with some suggestions in that regard.