bluuebunny/crossref_metadata_2025_split huggingface dataset:
Change in risk for narcolepsy over time and impact of definition of onset date following vaccination with AS03 adjuvanted pandemic A/H1N1 influenza vaccine (Pandemrix) during the 2009 H1N1 influenza pandemic
Authors: Granath Fredrik , Gedeborg Rolf , Smedje Hans , Feltelius Nils 
Published: May 2019

AbstractPurposeTo estimate risk for narcolepsy in defined time windows following exposure to adjuvanted A(H1N1) pandemic vaccine (Pandemrix) and impact of different definitions of index date for the narcolepsy diagnosis.MethodsVaccine exposure in approximately 30% of the Swedish population in 2009 was linked to information on narcolepsy diagnosis retrieved from the national patient registry. Cases were verified by a systematic chart review. Poisson regression was used to compare incidence in defined time windows following vaccination.ResultsOf 266 cases of narcolepsy identified, 25% (66/266) were prevalent cases with symptom onset documented before vaccine exposure. Incident cases had a median time interval between first symptom and the date recorded in the patient registry of 64 weeks (IQR 39‐107) when vaccinated (N = 182) and 65 weeks (IQR 51‐72) when unvaccinated (N = 16). With first symptom defining index date, the adjusted risk for narcolepsy in younger patients was increased 14 times during the first year after vaccination, three times elevated the second year, but with no detectable increased risk more than 2 years after vaccination exposure. Using the index date from the patient registry, the adjusted increase in risk was about seven times elevated for all three time intervals.ConclusionsThe magnitude of the estimated increased risk for narcolepsy following exposure to the A(H1N1) pandemic vaccine is highly dependent on the method used to determine the index date for disease onset. The sometimes very long and potentially variable interval from first symptom to a health care registry diagnosis complicates estimations of risk.
Partial differential equation modeling and vibration control for a nonlinear 3D rigid‐flexible manipulator system with actuator faults
Authors: Cao Fangfei , Liu Jinkun 
Published: May 2019

SummaryIn this paper, modeling and controlling problem for a two‐link rigid‐flexible manipulator in three‐dimensional (3D) space is studied under actuator faults. For modeling, the dynamics of the 3D mechanical system is represented by nonlinear partial differential equations, which is first derived in infinite dimension form. Based on the nonlinear model, the controller is proposed, which can achieve joint angle control and vibration suppression control in the presence of actuator faults. The stability analysis of the closed‐loop system is given based on LaSalle invariance principle. Numerical simulations illustrate the effectiveness of the proposed controller. This study will promote the development of nonlinear flexible manipulator systems in 3D space.
Preparation and Characterization of Dentin Phosphophoryn‐Derived Peptide‐Functionalized Lignin Nanoparticles for Enhanced Cellular Uptake
Authors: Figueiredo Patrícia , Sipponen Mika H. , Lintinen Kalle , Correia Alexandra , Kiriazis Alexandros , Yli‐Kauhaluoma Jari , Österberg Monika , George Anne , Hirvonen Jouni , Kostiainen Mauri A. , Santos Hélder A. 
Published: May 2019

AbstractThe surface modification of nanoparticles (NPs) using different ligands is a common strategy to increase NP−cell interactions. Here, dentin phosphophoryn‐derived peptide (DSS) lignin nanoparticles (LNPs) are prepared and characterized, the cellular internalization of the DSS‐functionalized LNPs (LNPs‐DSS) into three different cancer cell lines is evaluated, and their efficacy with the widely used iRGD peptide is compared. It is shown that controlled extent of carboxylation of lignin improves the stability at physiological conditions of LNPs formed upon solvent exchange. Functionalization with DSS and iRGD peptides maintains the spherical morphology and moderate polydispersity of LNPs. The LNPs exhibit good cytocompatibility when cultured with PC3‐MM2, MDA‐MB‐231, and A549 in the conventional 2D model and in the 3D cell spheroid morphology. Importantly, the 3D cell models reveal augmented internalization of peptide‐functionalized LNPs and improve antiproliferative effects when the LNPs are loaded with a cytotoxic compound. Overall, LNPs‐DSS show equal or even superior cellular internalization than the LNPs‐iRGD, suggesting that DSS can also be used to enhance the cellular uptake of NPs into different types of cells, and release different cargos intracellularly.
Adsorption of hexavalent chromium onto alkali‐modified biochar derived from Lepironia articulata: A kinetic, equilibrium, and thermodynamic study
Authors: Asadullah  , Kaewsichan Lupong , Tohdee Kanogwan 
Published: May 2019

AbstractHydrochar obtained after hydrothermal carbonization (HTC) of Lepironia articulata (LA) was modified into biochar by reacting with a specific amount of KOH in a tubular reactor under slow pyrolysis. The physical and chemical properties of the hydrochar and modified biochar were characterized. The performance of modified biochar (LABC) was investigated through batch sorption experiments. Removal (%) and the maximum adsorption capacity (qmax) of Cr(VI) onto LABC increased up to 98.9% and 28.75 mg/g relative to 63.44% and 21.90 mg/g in unmodified hydrochar (LAHC) at pH 2.0, 313 K, and 200 mg/L, respectively. The sorption kinetics uptake data were best interpreted with pseudo‐second‐order model, and sorption isotherm was simulated with the Langmuir adsorption model. The thermodynamic parameters confirm the adsorption process to be an endothermic, spontaneous, and increased disorder. The overall results revealed that LABC can be utilized as an environmentally friendly, inexpensive, and effective adsorbent in Cr(VI) removal.Practitioner points

Hydrochar and modified biochar prepared from a tropical biomass (Lepironia articulata) were successfully used for the removal of Cr(VI) from aqueous solution.

Increased specific surface was obtained by applying chemical modification with alkali treatment, contributing to effectiveness as adsorbent.

Dimensionless Kc was estimated from the Langmuir fits and then used to estimate thermodynamics of adsorption.

The signs of ∆H°, ∆G°, and ∆S° indicate that the adsorption of Cr(VI) onto LABC was an endothermic, spontaneous, and increased disorder.
How Do Interruptions Affect Productivity?
Authors: Brumby Duncan P. , Janssen Christian P. , Mark Gloria 
Published: May 2019

AbstractWork is frequently interrupted. What is known about how interruptions affect productivity? This important question has been studied using a variety of research methods, from controlled experiments designed to learn about the effect of interruptions on task performance, to analytical cognitive models that explain what makes an interruption disruptive, to in-situ observational studies that document the kinds of interruptions people experience in their actual workplaces. In this chapter, we review research on interruptions that has used these three research methods. We review what the methods entail, and what insights it has given on how interruptions affect productivity.
Kerr-de Sitter quasinormal modes via accessory parameter expansion
Authors: Novaes Fábio , Marinho Cássio I. S. , Lencsés Máté , Casals Marc 
Published: May 2019

AbstractQuasinormal modes are characteristic oscillatory modes that control the relaxation of a perturbed physical system back to its equilibrium state. In this work, we calculate QNM frequencies and angular eigenvalues of Kerr-de Sitter black holes using a novel method based on conformal field theory. The spin-field perturbation equations of this background spacetime essentially reduce to two Heun’s equations, one for the radial part and one for the angular part. We use the accessory parameter expansion of Heun’s equation, obtained via the isomonodromicτ-function, in order to find analytic expansions for the QNM frequencies and angular eigenvalues. The expansion for the frequencies is given as a double series in the rotation parameteraand the extremality parameterϵ= (rC−r+)/L, whereLis the de Sitter radius andrCandr+are the radii of, respectively, the cosmological and event horizons. Specifically, we give the frequency expansion up to orderϵ2for generala, and up to orderϵ3with the coefficients expanded up to (a/L)3. Similarly, the expansion for the angular eigenvalues is given as a series up to (aω)3with coefficients expanded for smalla/L. We verify the new expansion for the frequencies via a numerical analysis and that the expansion for the angular eigenvalues agrees with results in the literature.
Evaluation of Radiation Exposure During Sentinel Lymph Node Biopsy in Breast Cancer: A Retrospective Study
Authors: Burrah Rajaram , James Karen , Poonawala Shabbir 
Published: May 2019

AbstractIntroductionSentinel node biopsy (SNB) is the standard of care for nodal staging in breast cancer. Currently, radioisotope‐guided SNB is the standard technique. We have undertaken this study to analyse radiation exposure during SNB for breast cancer over a significant period of time.MethodsThe study was conducted over a period of 41 months and included 183 patients. The radioisotope was usually administered the day preceding the surgery at a dose of 40 MBq (±10%), and a lower dose of 20 MBq (±10%) was given if injected on the day of surgery. The radiation exposure was measured by dosimeters worn by the surgeon and surgical assistant.ResultsThe surgical procedures performed were mastectomy and SNB (56 patients), wide local excision and SNB (109 patients), and SNB alone (18 patients). The median time interval between the injection and surgery was 19.3 h, and median duration of surgery 93 min. The annual exposure for the surgeon was 0.125 mSv (range 0.01–0.03 mSv) and for the assistant was 0.265 (range 0.01–0.13 mSv).ConclusionContrary to other studies, we found the radiation exposure in the assistant was higher than that in the surgeon and we think this is because the assistant is positioned closer to the injection site during the procedure. However, the cumulative levels of radiation with SNB were very low and significantly below the permissible limits. The timing of injection, type of breast surgery and duration of procedure did not affect the levels of radiation exposure.
Eye-tracking and economic theories of choice under risk
Authors: Harrison Glenn W. , Swarthout J. Todd 
Published: May 2019

AbstractWe examine the ability of eye movement data to help understand the determinants of decision-making over risky prospects. We start with structural models of choice under risk, and use that structure to inform what we identify from the use of process data in addition to choice data. We find that information on eye movements does significantly affect the extent and nature of probability weighting behavior. Our structural model allows us to show the pathway of the effect, rather than simply identifying a reduced form effect. This insight should be of importance for the normative design of choice mechanisms for risky products. We also show that decision-response duration is no substitute for the richer information provided by eye-tracking.
In-process closed-loop control for stabilising the melt pool temperature in selective laser melting
Authors: Renken Volker , von Freyberg Axel , Schünemann Kevin , Pastors Felix , Fischer Andreas 
Published: May 2019

AbstractAdditive manufacturing processes are gaining more importance in the industrial production of metal components, as they enable complex geometries to be produced with less effort. The process parameters used to manufacture a wide variety of components are currently kept constant and closed-loop controls are missing. However, due to the part geometry that causes varying heat flow to neighbouring powder and solidified sections or due to deviations in the atmosphere caused by fumes within the work area, there are changes in the melt pool temperature. These deviations are not considered by system control, so far. It is, therefore, advisable to measure the melt temperature with sensors and to regulate the process. This work presents an approach that enables fast process control of the melt pool temperature and combines a closed-loop control strategy with a feedforward approach. The control strategies are tested by proof-of-concept experiments on a bridge geometry and partly powder-filled steel plates. Furthermore, results of a finite element simulation are used to validate the experimental results. Combining closed-loop and feedforward control reduces the temperature deviation by up to 90%. This helps to prevent construction errors and increases the part quality.
The integration of idioms of distress into mental health assessments and interventions: a systematic review
Authors: Cork C. , Kaiser B. N. , White R. G. 
Published: May 2019

Background.Psychiatric diagnostic manuals recognise the importance of local expressions of distress in culturally diverse settings [i.e. idioms/cultural concepts of distress (CCDs)], yet there is a lack of consensus on how these should be incorporated into mental health related research.Aims.To perform a narrative synthesis and critical review of research exploring how idioms/CCDs have been integrated into assessment measures and interventions.Method.A systematic review was conducted in accordance with PRISMA guidelines. An adapted version of the COSMIN checklist was used to assess the quality of the linguistic translation of the idioms/CCDs.Results.Twenty-nine papers were included in the final review. Primary qualitative research was the most common method of gathering information about idioms/CCDs. The majority of studies described integrating idioms/CCDs into assessment measures as opposed to interventions. Some studies used information relating to idioms/CCDs to develop novel assessment measures, while others adapted pre-existing assessment measures. The measures generated moderate to high levels of validity. Information relating to the linguistic translation conducted in the completion of the studies tended to be inadequately reported.Conclusions.Integrating information about idioms/CCDs into assessment measures can enhance the validity of these assessments. Allocating greater research attention to idioms/CCDs can also promote more equitable exchanges of knowledge about mental health and wellbeing between the Global North and the Global South.
Don't Judge a Wine by Its Closure: Price Premiums for Corks in the U.S. Wine Market
Authors: Bekkerman Anton , Brester Gary W. 
Published: May 2019

AbstractFor many purchases, consumers often possess only limited information about product quality. Thus, observable product characteristics are used to determine expected quality levels when making purchase decisions. We use more than 1 million weekly scanner-level observations from grocery stores across ten U.S. markets between September 2009 and August 2012 to examine how consumers value a wine bottle's closure type (i.e., cork or screw cap). We focus on lower-priced wines—those with sale prices less than $30 per 750 milliliter bottle—to more accurately evaluate decisions of consumers for whom seeking additional information about wine quality is likely more costly than the benefits derived from that information. Using both pooled ordinary least squares and quantile regressions to estimate price premiums for bottles with corks or screw caps, we find that U.S. consumers are willing to pay, on average, approximately 8% more (about $1.00) for a bottle of wine that has a cork closure. In addition, we show that the size of this premium increases as wine prices decline. (JEL Classifications: D81, M31, Q11)
Competition Policy in the Wine Industry in Europe
Authors: Rizzo Andrea Minuto 
Published: May 2019

AbstractIn recent years, several European antitrust authorities intervened in the wine sector to authorize mergers and acquisitions, provide opinions to governments, and ascertain anticompetitive agreements. This article analyzes these interventions in the context of an evolving regulatory framework. I draw conclusions about the direction of competition policy, in particular in relation to possible co-operations among various players in the wine industry. (JEL Classifications: K21, L40, L51)
‘A place of great trust to be supplied by men of skill and integrity’: assayers and knowledge cultures in late sixteenth- and seventeenth-century London
Authors: KILBURN-TOPPIN JASMINE 
Published: May 2019

AbstractThis article suggests that institutional workshops of assay were significant experimental sites in early modern London. Master assayers at Goldsmiths’ Hall on Foster Lane, in the heart of the city, and at the Royal Mint, in the Tower, made trials to determine the precious-metal content of bullion, plate and coinage. The results of their metallurgical experiments directly impacted upon the reputations and livelihoods of London's goldsmiths and merchants, and the fineness of coin and bullion. Engaged in the separation and transformation of matter, assayers and the affairs of their workshops were also a curiosity for those interested in the secrets of nature. Making use of a wide-ranging body of sources, including institutional court minutes, artisanal petitions, mercantile guidebooks, recipe books and natural-philosophical treatises, this article uncovers a complex culture of metropolitan expertise. We first examine the workshop spaces in which assayers undertook their professional activities, and their secretive corporate cultures. We turn next to the manuscript culture through which assayers codified and communicated knowledge, ‘secrets’ and techniques to broader urban audiences. Finally, we assess exchanges and tensions between assayers and the wider community of Londoners engaged in scientific knowledge production and dissemination.
Glycaemic regulation, appetite and ex vivo oxidative stress in young adults following consumption of high-carbohydrate cereal bars fortified with polyphenol-rich berries
Authors: Smith Tracey J. , Karl James Philip , Wilson Marques A. , Whitney Claire C. , Barrett Ann , Farhadi Nicole Favreau , Chen Chung-Yen Oliver , Montain Scott J. 
Published: May 2019

AbstractConsumption of certain berries appears to slow postprandial glucose absorption, attributable to polyphenols, which may benefit exercise and cognition, reduce appetite and/or oxidative stress. This randomised, crossover, placebo-controlled study determined whether polyphenol-rich fruits added to carbohydrate-based foods produce a dose-dependent moderation of postprandial glycaemic, glucoregulatory hormone, appetite andex vivooxidative stress responses. Twenty participants (eighteen males/two females; 24 (sd5) years; BMI: 27 (sd3) kg/m2) consumed one of five cereal bars (approximately 88 % carbohydrate) containing no fruit ingredients (reference), freeze-dried black raspberries (10 or 20 % total weight; LOW-Rasp and HIGH-Rasp, respectively) and cranberry extract (0·5 or 1 % total weight; LOW-Cran and HIGH-Cran), on trials separated by ≥5 d. Postprandial peak/nadir from baseline (Δmax) and incremental postprandial AUC over 60 and 180 min for glucose and other biochemistries were measured to examine the dose-dependent effects. Glucose AUC0–180 mintrended towards being higher (43 %) after HIGH-Raspv.LOW-Rasp (P=0·06), with no glucose differences between the raspberry and reference bars. Relative to reference, HIGH-Rasp resulted in a 17 % lower Δmaxinsulin, 3 % lower C-peptide (AUC0–60 minand 3 % lower glucose-dependent insulinotropic polypeptide (AUC0–180 min)P&lt;0·05. No treatment effects were observed for the cranberry bars regarding glucose and glucoregulatory hormones, nor were there any treatment effects for either berry type regardingex vivooxidation, appetite-mediating hormones or appetite. Fortification with freeze-dried black raspberries (approximately 25 g, containing 1·2 g of polyphenols) seems to slightly improve the glucoregulatory hormone and glycaemic responses to a high-carbohydrate food item in young adults but did not affect appetite or oxidative stress responses at doses or with methods studied herein.
Late Tertiary fault activity in the southwestern boundary fault system of the Roer Valley Graben: evidences from the Bree area (NE Belgium)
Authors: Sintubin M. , Sels O. , Buffel P. 
Published: May 2019

AbstractThe Bree Uplift is a particular structure in the direct footwall of the southwestern graben boundary fault system of the Roer Valley Graben, which has been firstly recognized at the base of the Cretaceous. To date fault activity around the Bree Uplift has been confined to the Subhercynian (late Cretaceous) inversion event or considered fading out during Tertiary times.The revision of the existing geological data reveals that the Bree Uplift can still be recognized on the top-Tertiary map. This infers at least a late Tertiary activity, suggesting continuous fault activity in the graben boundary fault system not only on the major boundary faults but also on different splay faults, bounding individual fault blocks.
Colonization With Methicillin-Resistant Staphylococcus aureus in ICU Patients Morbidity, Mortality, and Glycopeptide Use
Authors: Garrouste-Orgeas Maité , Timsit Jean-Francois , Kallel Hatem , Ali Adel Ben , Dumay Marie Francoise , Paoli Benedicte , Misset Benoit , Carlet Jean 
Published: May 2019

AbstractObjective:To determine the impact of methicillin-resis-tant Staphylococcus aureus (MRSA) colonization on the occurrence of S aureus infections (methicillin-resistant and methicillin-suscep-tible), the use of glycopeptides, and outcome among intensive care unit (ICU) patients.Design:Prospective observational cohort survey.Setting:A medical-surgical ICU with 10 single-bed rooms in a 460-bed, tertiary-care, university-affiliated hospital.Patients:A total of 1,044 ICU patients were followed for the detection of MRSA colonization from July 1, 1995, to July, 1 1998.Methods:MRSA colonization was detected using nasal samples in all patients plus wound samples in surgical patients within 48 hours of admission or within the first 48 hours of ICU stay and weekly thereafter. MRSA infections were defined using Centers for Disease Control and Prevention standard definitions, except for ventilator-associated pneumonia and catheter-related infections, which were defined by quantitative distal culture samples.Results:One thousand forty-four patients (70% medical patients) were included in the analysis. Mean age was 61±18 years; mean Simplified Acute Physiologic Score (SAPS) II was 36.4±20; and median ICU stay was 4 (range, 1-193) days. Two hundred thirty-one patients (22%) died in the ICU. Fifty-four patients (5.1%) were colonized with MRSA on admission, and 52 (4.9%) of 1,044 acquired MRSA colonization in the ICU. Thirty-five patients developed a total of 42 S aureus infections (32 MRSA, 10 methi-cillin-susceptible). After factors associated with the development of an S aureus infection were adjusted for in a multivariate Cox model (SAPS II >36: hazard ratio [HR], 1.64; P=.09; male gender: HR, 2.2; P=.05), MRSA colonization increased the risk of S aureus infection (HR, 3.84; P=.0003). MRSA colonization did not influence ICU mortality (HR, 1.01; P=.94). Glycopeptides were used in 11.4% of the patients (119/1,044) for a median duration of 5 days. For patients with no colonization, MRSA colonization on admission, and ICU-acquired MRSA colonization, respectively, glycopeptide use per 1,000 hospital days was 37.7, 235.2, and 118.3 days. MRSA colonization per se increased by 3.3-fold the use of glycopeptides in MRSA-colonized patients, even when an MRSA infection was not demonstrated, compared to non-colonized patients.Conclusions:In our unit, MRSA colonization greatly increased the risk of S aureus infection and of glycopeptide use in colonized and non-colonized patients, without influencing ICU mortality. MRSA colonization influenced glycopeptide use even if an MRSA infection was not demonstrated; thus, an MRSA control program is warranted to decrease vancomycin use and to limit glycopeptide resistance in gram-positive cocci.