bluuebunny/crossref_metadata_2025_split huggingface dataset:
Intraoperative Findings of Lateral Ligament Avulsion Fractures and Outcome After Refixation to the Fibula
Authors: Diallo Jasmin , Wagener Joe , Schweizer Christine , Lang Tamara Horn , Ruiz Roxa , Hintermann Beat 
Published: March 2018

Background: An acute ankle sprain can result in a bony avulsion of the lateral ankle ligaments. The extent of concomitant lesions and subsequent instability patterns are not clearly understood. The high incidence of old avulsion fractures found in symptomatic chronic ankle instability may indicate the need for primary fixation. Methods: Ten patients (5 male, 5 female; mean age, 34 years; range, 15–64 years) with bony avulsion fractures of the fibula after acute ankle sprains were included. All patients were treated after a mean of 7.7 days (range, 2–17 days) with screw fixation of the fragment to the fibula. Clinical and radiographic assessments were performed, and the extent of ligament injury was documented. Results: The anterior talofibular ligament and calcaneofibular ligament were found to be attached to the avulsion fragment. The average size was 6.3 mm (range, 4–9 mm) in width from anterior to posterior and 5.2 mm (range, 4–7 mm) in length from superior to inferior. The displacement of the fragment increased under varus stress. Two patients had cartilage lesions in the lateral talus. After a mean follow-up period of 2.4 years (range, 2–4 years), all were clinically and radiographically stable, and patients were satisfied. Conclusions: It was observed arthroscopically that the anterior talofibular ligament and calcaneofibular ligament were attached to the fragment. This is critical because motion between the fragment and the fibula may prevent spontaneous healing. Primary fixation of the fragment prevented rotational instability and was efficient to restore function and stability. Level of Evidence: Level IV, retrospective case series.
Clinical Efficacy of Diphenylcyclopropenone Immunotherapy as Monotherapy for Multiple Viral Warts
Authors: Park Jun Yeong , Park Bok Won , Cho Eun Byul , Park Eun Joo , Kim Kwang Ho , Kim Kwang Joong 
Published: March 2018

Background: Diphenylcyclopropenone (DPCP) immunotherapy for viral warts has been used for many years, but no studies have analyzed the treatment effects of DPCP alone, without the use of conventional therapy before immunotherapy. Objectives: We evaluated clinical efficacy of DPCP monotherapy compared to cryotherapy and pulsed dye laser (PDL) therapy. We also assessed the impact of initial sensitization on clinical response. Methods: We retrospectively analyzed the medical records of 250 patients with multiple viral warts between January 2008 and December 2015. Results: The DPCP-only group (n = 43) showed a lower clinical response (75.6%) than the cryotherapy-only group (n = 171, 89.8%, P < .01) and PDL-only group (n = 36, 90.3%, P < .01). The positive clinical response was 76.3% (119/156) in the successful sensitization group (n = 21) and 74.4% in the failed sensitization group ( P = .870). Conclusions: DPCP monotherapy has a lower clinical response than conventional therapy. Initial sensitization to DPCP does not predict a failed response with continued immunotherapy for viral warts.
Physician decision making in anticoagulating atrial fibrillation: a prospective survey of a physician notification system for atrial fibrillation detected on cardiac implantable electronic devices of patients at increased risk of stroke
Authors: Cloutier Justin M. , Khoo Clarence , Hiebert Brett , Wassef Anthony , Seifer Colette M. 
Published: March 2018

Objectives: The objectives of this study were to evaluate the effectiveness of a physician notification system for atrial fibrillation (AF) detected on cardiac devices, and to assess predictors of anticoagulation in patients with device-detected AF. Methods: In 2013, a physician notification system for AF detected on a patient’s CIED [including pacemakers, implantable cardioverter defibrillators (ICD) or cardiac resynchronization therapy (CRT) devices] was implemented, with a recommendation to consider oral anticoagulation in high-risk patients. We prospectively investigated the effectiveness of this system, and evaluated both patient and physician predictors of anticoagulation, as well as factors influencing physician decision making in prescribing anticoagulation. Both uni- and multivariable analysis as well as descriptive statistics were used in the analysis. Results: We identified 177 patients with device-detected AF, 126 with a CHADS2 ⩾2. Only 41% were prescribed anticoagulation at any point within 12 months. On multivariable analysis, stroke risk as predicted by CHADS2 was not a predictor of anticoagulation. ASA use predicted a lower rate of anticoagulation (OR 0.39, 95% CI 0.16–0.97, p = 0.04); physicians in practice for <20 years were more likely to prescribe anticoagulation (OR 3.39, 95% CI 1.28–8.93, p = 0.01); and physicians who believed both cardiologist and family doctor should be involved in managing anticoagulation were more likely to prescribe anticoagulation (OR 3.28, 95% CI 1.02–10.5, p = 0.05). Conclusions: Patients on aspirin were less likely to be anticoagulated. Physicians in practice for <20 years and who believed that both the general practitioner and cardiologist should be involved in managing anticoagulants were more likely to prescribe anticoagulation.
High Tibial Osteotomy Performed With All-PEEK Implants Demonstrates Similar Outcomes but Less Hardware Removal at Minimum 2-Year Follow-up Compared With Metal Plates
Authors: Roberson Troy A. , Momaya Amit M. , Adams Kyle , Long Catherine D. , Tokish John M. , Wyland Douglas J. 
Published: March 2018

Background: High tibial osteotomy (HTO) is a valuable treatment option in the high-demand patient with chondral damage and an altered mechanical axis. Traditional opening wedge HTO performed with metal plates has several limitations, including hardware irritation, obscuration of detail on magnetic resonance imaging, and complexity of revision surgery. Recently, an all-polyetheretherketone (PEEK) HTO implant was introduced, but no studies to date have evaluated the performance of this implant with minimum 2-year outcomes compared with a traditional metal plate. Purpose: To compare patient outcomes and complications of HTO performed using a traditional metal plate with those performed using an all-PEEK implant. Study Design: Cohort study; Level of evidence, 3. Methods: All patients who underwent HTO by a single surgeon with a minimum 2-year follow-up over a 4-year period were identified. Medical records were reviewed for patient demographics, concomitant procedures, implant used, type and degree of correction, complications, reoperations, and failures. Recorded patient outcomes included EuroQol–5 dimensions (EQ-5D), resiliency, Single Assessment Numeric Evaluation (SANE), Tegner activity level scale, International Knee Documentation Committee (IKDC), and Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) scores. HTO performed using a traditional metal plate served as the control group. Statistical analysis was performed using the Student t test for continuous variables and chi-square analysis for nonparametric data, with P < .05 considered significant. Results: A total of 41 patients (21 in the all-PEEK group, 20 in the control group) were identified with greater than 2-year follow-up. The mean patient age was 44 years, and there were no differences between the groups with regard to demographics, degree of correction, or concomitant procedures. In addition, no significant differences were found for any of the patient-reported outcomes. Complications (10% vs 15%, respectively; P = .59), failures (10% vs 5%, respectively; P = .58), and reoperations (10% vs 30%, respectively; P = .10) were similar for the all-PEEK and control groups. However, the all-PEEK group did not have any hardware removal, while 4 patients in the control group underwent hardware removal ( P = .03). Conclusion: This study suggests that an all-PEEK implant may be safely used with comparable outcomes and complication rates to the traditional method but with less need for hardware removal.
MicroRNA-17-92 is required for T-cell and B-cell pathogenicity in chronic graft-versus-host disease in mice
Authors: Wu Yongxia , Schutt Steven , Paz Katelyn , Zhang Mengmeng , Flynn Ryan P. , Bastian David , Sofi M. Hanief , Nguyen Hung , Dai Min , Liu Chen , Chang Ying-Jun , Blazar Bruce R. , Yu Xue-Zhong 
Published: March 2018

Key Points
miR-17-92 mediates the progression of scleroderma and bronchiolitis obliterans in cGVHD by enhancing T- and B-cell responses. Pharmacologically blocking the activity of miR-17-92 with an anti–miR-17 antagomir effectively alleviates cGVHD.
Stearoyl-CoA desaturase-1 promotes colorectal cancer metastasis in response to glucose by suppressing PTEN
Authors: Ran Hui , Zhu Yemin , Deng Ruyuan , Zhang Qi , Liu Xisheng , Feng Ming , Zhong Jie , Lin Shuhai , Tong Xuemei , Su Qing 
Published: March 2018

Abstract

Background
Diabetic patients have a higher risk factor for colorectal cancer (CRC) metastasis. Stearoyl-CoA desaturase 1 (SCD1), the main enzyme responsible for producing monounsaturated fatty acids(MUFA) from saturated fatty acids, is frequently deregulated in both diabetes and CRC. The function and mechanism of SCD1 in metastasis of CRC and its relevance to glucose remains largely unknown.

Methods
SCD1 expression levels were analyzed in human CRC tissues and the Cancer Browser database (https://genome-cancer.ucsc.edu/). CRC cell lines stably transfected with SCD1 shRNAs or vector were established to investigate the role of SCD1 in modulating migration and invasion of CRC cells. A glucose concentration gradient was set to investigate regulation of SCD1 in CRC relevant to diabetic conditions.

Results
The clinical data analysis showed high expression of SCD1 in CRC tissues with a negative correlation with the prognosis of CRC. In vitro experiments revealed that SCD1 increased CRC progression through promoting epithelial–mesenchymal transition (EMT). Lipidomic analysis demonstrated that SCD1 increased MUFA levels and MUFA administration could rescue migration and invasion defect of CRC cells induced by SCD1 knockdown. Furthermore, SCD1-mediated progression of CRC was promoted by carbohydrate response-element binding protein (ChREBP) in response to high glucose. Mechanistically, hyperglycemia-SCD1-MUFA induced CRC cell migration and invasion by regulating PTEN.

Conclusions
Our findings show that SCD1 promotes metastasis of CRC cells through MUFA production and suppressing PTEN in response to glucose, which may be a novel mechanism for diabetes-induced CRC metastasis.
Revolving Rating Analysts and Ratings of Mortgage-Backed and Asset-Backed Securities: Evidence from LinkedIn
Authors: Jiang John (X.) , Wang Isabel Y. , Wang K. Philip 
Published: March 2018

This study examines whether revolving rating analysts who transition from major rating agencies to issuers are associated with any rating inflation in the issuers’ mortgage-backed securities (MBS) or asset-backed securities (ABS). Using professional profiles posted on LinkedIn to identify revolving rating analysts with structured finance rating experience, we find that the more the issuers employ such analysts, the more likely that ratings of issuers’ MBS and ABS new issuances are inflated compared with otherwise similarly rated securities. Additional analyses show that the impact of revolving rating analysts is more pronounced in complex deals and when the revolving analysts are more senior, indicating that rating expertise in structured finance may play a role in MBS and ABS rating inflation. Finally, we find that at least for AAA-rated MBS and ABS, investors fail to see through the rating inflation associated with revolving rating analysts. The online appendix is available at https://doi.org/10.1287/mnsc.2017.2921 . This paper was accepted by Shivaram Rajgopal, accounting.
A presença de Dioniso nas taças de vinho kylikes decoradas com grandes olhos monumentais do período arcaico dos gregos
Authors: Candido Maria Regina 
Published: March 2018

O conjunto de vasos em terracota no formato de kylix detém a função social de taça para beber vinho que, provavelmente, circulava junto aos simposiastas nos banquetes. Acredito que ao final da festa as taças eram depositadas no santuário do deus Dioniso. A aparência das kylikes que selecionamos detém a peculiaridade de simular uma face devido à presença de dois grandes pares de olhos.
Ritmo em Aristóxeno
Authors: Gouvêa Artur 
Published: March 2018

Este trabalho apresenta pesquisa, tradução e comentários sobre o texto Elementos de ritmo, escrito pelo antigo estudioso da música Aristóxeno de Tarento, com o intuito de elucidar questões concernentes aos termos por ele utilizados para descrever os fenômenos musicais relacionados à organização do tempo e, consequentemente, aos agrupamentos das durações, tentando traçar um paralelo entre a forma de responder a esses fenômenos no período antigo e hodiernamente. Para tal, tentar-se-á localizar de forma suscinta Aristóxeno no contexto de seu tempo e provocar discussões a partir de excertos traduzidos do texto grego estabelecido por Christopher Marchetti que evidenciarão o choque entre o discurso antigo, presente no texto de Aristóxeno, e o discurso que parte da vivência contemporânea particular do autor deste documento. Palavras-chave: Aristóxeno - Música - Ritmo
La Séptima Gran Cosmovisión: Mecánica Cuántica y Universo Consciente
Authors: Castilla Adolfo 
Published: March 2018

Se aborda en este trabajo un tema tan antiguo y general, pero al mismo tiempo tan actual, como las diferencias y posibles relaciones entre la materia y el espíritu. Se hace a través de la consideración de fenómenos como las «cosmovisiones», o interpretaciones generales de lo que es nuestro mundo y lo que los hombres hacemos en él, surgidos periódicamente en la humanidad como consecuencia de grandes descubrimientos y grandes teorías explicativas de la naturaleza de nuestro universo, incluyendo al hombre dentro de él. Sugerimos que estamos entrando en la séptima cosmovisión y la definimos en términos generales. El perfeccionamiento de la especie humana fisiológica y mentalmente puede que sea uno de los resultados concretos a los que pueden dar lugar las nuevas interpretaciones y los cambios tecnológicos que las acompañan, así como la utilización de la Inteligencia Artificial Fuerte y la creación de robots humanoides y «máquinas espirituales». Más importante que todo ello, y a lo que especialmente nos referimos, es el hecho de que la nueva etapa del hombre ante la que estamos, puede caracterizarse por un mayor papel del espíritu, la consciencia, y la subjetividad en la marcha de nuestro mundo, algo a lo que contribuyen las nuevas concepciones relacionadas con la Mecánica Cuántica y con la posibilidad de existencia de un Universo Consciente.
Fractone Bulbs Derive from Ependymal Cells and Their Laminin Composition Influence the Stem Cell Niche in the Subventricular Zone
Authors: Nascimento Marcos Assis , Sorokin Lydia , Coelho-Sampaio Tatiana 
Published: March 2018

Fractones are extracellular matrix structures in the neural stem cell niche of the subventricular zone (SVZ), where they appear as round deposits named bulbs or thin branching lines called stems. Their cellular origin and what determines their localization at this site is poorly studied, and it remains unclear whether they influence neural stem and progenitor cell formation, proliferation, and/or maintenance. To address these questions, we analyzed whole-mount preparations of the lateral ventricle of male and female mice by confocal microscopy using different extracellular matrix and cell markers. We found that bulbs are rarely connected to stems and that they contain laminin α5 and α2 chains, respectively. Fractone bulbs were profusely distributed throughout the SVZ and appeared associated with the center of pinwheels, a critical site for adult neurogenesis. We demonstrate that bulbs appear at the apical membrane of ependymal cells at the end of the first week after birth. The use of transgenic mice lacking laminin α5 gene expression (Lama5) in endothelium and in FoxJ1-expressing ependymal cells revealed ependymal cells as the source of laminin α5-containing fractone bulbs. Deletion of laminin α5 from ependymal cells correlated with a 60% increase in cell proliferation, as determined by phospho-histone H3 staining, and with a selective reduction in the number of slow-dividing cells. These results indicate that fractones are a key component of the SVZ and suggest that laminin α5 modulates the physiology of the neural stem cell niche.SIGNIFICANCE STATEMENTOur work unveils key aspects of fractones, extracellular matrix structures that are present in the SVZ that still lack a comprehensive characterization. We show that fractones extensively interact with neural stem cells, whereas some of them are located precisely at pinwheel centers, which are hotspots for adult neurogenesis. Our results also demonstrate that fractones increase in size during aging and that their interactions with neural stem and progenitor cells become more complex in old mice. Last, we show that fractone bulbs are produced by ependymal cells and that their laminin content regulates neural stem cells.
Determination of the psychometric properties of the Patients’ Self-Efficacy Scale in blood pressure patients
Authors: Ghadiri Raheleh , Alimohammadi Masoumeh , Majdabadi Hesamedin Askari 
Published: March 2018

Introduction
This study was designed to determine self-efficacy and its related factors in patients with hypertension.

Materials and methods
This study is descriptive-sectional from the correlation. A total of 250 patients from a blood pressure clinic of Semnan city (in Iran) completed Medication Understanding and Use Self-Efficacy Scale were randomly selected in 2017. Data were analyzed using variance, Pearson’s Correlation, and χ2 using the LISREL 8.8 software.

Results
The items 1, 6, 7, and 8 have high correlation (at least higher than 0.60), indicating the possibility of aggregation of these four variables in the first factor (taking medication), and the four items 2, 3, 4, and 5 are highly correlated with each other, which are the second factor (learning about medication). In addition, Cronbach’s α of reliability (taking medication) for the first factor was 0.67 and 0.63 for the second factor (learning about medication) and 0.69 for the whole scale.

Conclusion
The effectiveness of blood pressure self-efficacy is an appropriate tool for measure-taking responsibility for the time and taking medications by patients, and researchers can use it as a valid tool in therapeutic, psychological, and health research.
Matrix-assisted laser desorption ionization–time of flight mass spectrometry for identification of bacteria isolated from pharmaceutical clean rooms
Authors: Andrade Laíse de Oliveira , Awasthi Rajendra , Dua Kamal , de Jesus Andreoli Pinto Terezinha 
Published: March 2018

Introduction
During the manufacturing of sterile drugs, it is of the utmost importance to meet the minimum requirements for asepsis recommended by the legislations on good manufacturing practices-based efficient environmental monitoring.

Aims and methods
The availability of relatively simple to use matrix-assisted laser desorption ionization–time of flight mass spectromtomy (MALDI-TOF MS) devices in the last years has changed the laboratory workflows for the microbial identification, mainly in the clinical area. Thus, the objective of this work was to evaluate the suitability of the MALDI-TOF MS technique for the identification of bacteria isolated from the environment of clean rooms used in some stages of the production of a viral vaccine. Eighteen known bacterial species commonly isolated from clean rooms studied were identified by MALDI-TOF technique and by a biochemical technique (BBL Crystal® System).

Results
Performance of MALDI-TOF MS was better than biochemical technique for correct species identifications (88.89% and 38.89%, respectively) and produced less unreliable identification (5.55% and 22.22%).

Conclusion
MALDI-TOF MS can be implemented for routine identification of bacteria in a pharmaceutical quality control laboratory, but as a database-dependent system, maybe some isolated not identified by this technique must be additionally studied and, if appropriate, added to an in-house database.
A gramática estadunidense como alteridade para a gramatização brasileira do português no século XIX : análise da composição da gramática Holmes Brazileiro ou Grammatica da Puericia de Júlio Ribeiro (1886) a partir do modelo do compêndio A Grammar of the English Language de George Frederick Holmes (1878)
Authors: De Aquino José Edicarlos 
Published: March 2018

Resumo: Este artigo analisa os procedimentos de Júlio Ribeiro para compor a sua gramática Holmes Brazileiro Grammatica da Puericia, em 1886, com base no modelo do compêndio A Grammar of the English Language, lançada por George Frederick Holmes em 1878. Ilustrando em detalhes o mecanismo de transferência de tecnologia entre línguas segundo o conceito de gramatização de Auroux (1992), essa análise nos permite trazer à luz um elemento pouco observado na história das ideias linguísticas no Brasil, isto é, a alteridade que a gramática estadunidense representa para a gramatização brasileira do português no século XIX. Dessa forma, detalhamos as várias modificações que Júlio Ribeiro opera no texto de Holmes ao traduzi-lo e adaptá-lo para a escrita de uma gramática do português, mostrando como elas se realizam por exigência das especificidades da ordem da própria língua, mas também como significam um gesto de autoria do gramático brasileiro sobre o conhecimento linguístico, inserindo, inclusive, referências ao Brasil no discurso gramatical.Palavras-chave: gramatização brasileira; século XIX; Júlio Ribeiro; George Frederick Holmes; gramática brasileira, gramática estadunidense; gramática latina extensa.Abstract: This article analyzes the procedures of Júlio Ribeiro to compose his grammar Holmes Brazileiro Grammatica da Puericia, in 1886, from the model of the compendium A Grammar of the English Language, released by George Frederick Holmes in 1878. Illustrating in detail the technology transfer mechanism between languages according to Auroux’s concept of grammatization (1992), this analysis allows us to bring to light an unobserved element observed in the history of linguistic ideas in Brazil, that is, the alterity that the American grammar represents for the Brazilian grammatization of Portuguese in the nineteenth century. In this way, we detail the various modifications that Júlio Ribeiro operates in Holmes’s text by translating it and adapting it to the writing of a Portuguese grammar, showing how they are performed by exigency of the specifics of the order of the language itself, but also as signify a gesture of authorship by the Brazilian grammarian about linguistic knowledge, including references to Brazil in grammatical discourse.Keywords: Brazilian grammatization; nineteenth century; Júlio Ribeiro; George Frederick Holmes; Brazilian grammar, American grammar; extended Latin grammar.
Un capítulo poco conocido del estudio diccionarístico: La terminografía lexicográfica. Estado y propuestas
Authors: Camacho Niño Jesús 
Published: March 2018

La investigación presentada es de carácter metalexicográfico y toma la terminología de especialidad lexicográfica como objeto de estudio, siendo su objetivo conocer el desarrollo de los estudios referentes a este subconjunto léxico. Así, a lo largo de las siguientes páginas ahondaremos en las distintas reflexiones que se han realizado en torno a la terminografía lexicográfica desde sus inicios hasta su actualidad más reciente. El acercamiento pretende ser lo más exhaustivo posible, intentando incluir todas las ponderaciones realizadas en torno a este aspecto del estudio lexicográfico. Por ello, no solo se ha atendido a la lexicografía de ámbito hispánico, sino que también han tenido cabida propuestas terminográficas en otras lenguas: inglés, alemán, polaco o noruego, lo que garantizará, al menos en parte, la coherencia y validez de los resultados obtenidos.