bluuebunny/crossref_metadata_2025_split huggingface dataset:
China's Energy Consumption in the New Normal
Authors: Mi Zhifu , Zheng Jiali , Meng Jing , Shan Yuli , Zheng Heran , Ou Jiamin , Guan Dabo , Wei Yi‐Ming 
Published: June 2018

AbstractEnergy consumption is one of main reasons for global warming and highly correlated with economic development. As the largest energy consumer worldwide, China has entered a new economic development model—the “new normal.” This study aims to explore the pattern shift in China's energy consumption growth in this new development phase. We use structural decomposition analysis and environmentally extended input‐output analysis to decompose China's energy consumption changes during 2005–2012 into five factors: population, efficiency, production structure, consumption patterns, and consumption volume. During the period of the global financial crisis, the energy consumption generated by China's exports dropped, while the energy consumption generated by capital formation grew rapidly. Over three quarters of China's energy consumption growth was caused by capital formation during 2007–2010. This growth is mainly because of China's economic stimulus measures in response to the global recession, with a focus on infrastructure construction. In the new normal, the strongest factors offsetting China's energy consumption have been shifting from efficiency gains to structural changes. Efficiency gains were the strongest factor offsetting China's energy consumption in traditional development model and offset 42% of energy consumption between 2005 and 2010 by keeping other driving forces constant. Since 2010, however, their effects offsetting energy have become weak. The production structure and consumption patterns both drove China's energy consumption growth in the traditional development model and drove energy consumption growth by 31% and 12% between 2005 and 2010, respectively. Since 2010, however, both factors have started to offset China's energy consumption.
Clonal Vegetation Patterns Mediate Shoreline Erosion
Authors: Bernik Brittany M. , Eppinga Maarten B. , Kolker Alexander S. , Blum Michael J. 
Published: June 2018

AbstractUnderstanding processes governing coastal erosion is becoming increasingly urgent because highly valued ecosystems like salt marshes are being lost at accelerating rates. Here we examine the role of biotic interactions in mediating marsh shoreline erosion under wind wave forces. We parameterized analytical and cellular automata models with field data to assess how soil heterogeneity among clonal patches of an ecosystem engineer mediates spatiotemporal patterns of marsh shoreline erosion. We found that spatial heterogeneity accelerates erosion, especially when it is organized in patches of intermediate size. Patch size also mediated interannual variability in erosion and strongly controlled shoreline roughness. Our results indicate that shoreline roughness can be diagnostic of internal biological structure and spatiotemporal variability in erosion. Hence, measures of shoreline roughness may inform the timeframe and spatial extent needed to accurately monitor erosion. These findings highlight how the physical response of marsh shorelines to wind wave erosion is a function of landscape ecology.
Variability of the Ross Gyre, Southern Ocean: Drivers and Responses Revealed by Satellite Altimetry
Authors: Dotto Tiago S. , Naveira Garabato Alberto , Bacon Sheldon , Tsamados Michel , Holland Paul R. , Hooley Jack , Frajka‐Williams Eleanor , Ridout Andy , Meredith Michael P. 
Published: June 2018

AbstractYear‐round variability in the Ross Gyre (RG), Antarctica, during 2011–2015, is derived using radar altimetry. The RG is characterized by a bounded recirculating component and a westward throughflow to the south. Two modes of variability of the sea surface height and ocean surface stress curl are revealed. The first represents a large‐scale sea surface height change forced by the Antarctic Oscillation. The second represents semiannual variability in gyre area and strength, driven by fluctuations in sea level pressure associated with the Amundsen Sea Low. Variability in the throughflow is also linked to the Amundsen Sea Low. An adequate description of the oceanic circulation is achieved only when sea ice drag is accounted for in the ocean surface stress. The drivers of RG variability elucidated here have significant implications for our understanding of the oceanic forcing of Antarctic Ice Sheet melting and for the downstream propagation of its ocean freshening footprint.
Modeling of Dissolution‐Induced Permeability Evolution of a Granite Fracture Under Crustal Conditions
Authors: Lu Renchao , Nagel Thomas , Shao Hua , Kolditz Olaf , Shao Haibing 
Published: June 2018

AbstractThis work focuses on the interaction between pressure solution creep and contact area expansion under hydrothermal conditions and proposes an innovative process‐based approach for describing contact area expansion by fracture closure. The formulation is established in the physical context of pressure solution creep and represents the dynamic process of enhanced mineral dissolution over grain contacts, which moves toward equilibrium as a result of decrease of mineral solubility by pressure drop. Then, a theoretical maximum of the contact area ratio Rc,max is obtained from the formulation whose existence demonstrates that pressure solution is with an energy threshold for activation rather than spontaneously taking place under any circumstances. Based upon the formulation, a 1‐D reactive transport model is developed and applied to investigate dissolution‐induced permeability evolution of a granite fracture under crustal conditions. The applicability of the developed model to a polymineralic system is examined against the experimental measurements reported in Yasuhara et al. (2011, https://doi.org/10.1016/j.apgeochem.2011.07.005). This investigation reconfirms the significance of pressure solution creep in fracture permeability evolution under low and moderate temperatures and provides a justified interpretation for the unusual experimental observation that fracture permeability reduction does not necessarily lead to apparent increases of effluent element concentrations. The surface topography of fracture channels markedly affects hydraulic feedback on chemical compaction in terms of both magnitude and rate of change. Temperature elevation contributes to accelerating the progression of pressure solution creep.
SRSF3 maintains transcriptome integrity in oocytes by regulation of alternative splicing and transposable elements
Authors: Do Dang Vinh , Strauss Bernhard , Cukuroglu Engin , Macaulay Iain , Wee Keng Boon , Hu Tim Xiaoming , Igor Ruiz De Los Mozos , Lee Caroline , Harrison Andrew , Butler Richard , Dietmann Sabine , Jernej Ule , Marioni John , Smith Christopher W. J. , Göke Jonathan , Surani M. Azim 
Published: June 2018

AbstractThe RNA-binding protein SRSF3 (also known as SRp20) has critical roles in the regulation of pre-mRNA splicing. Zygotic knockout of Srsf3 results in embryo arrest at the blastocyst stage. However, SRSF3 is also present in oocytes, suggesting that it might be critical as a maternally inherited factor. Here we identify SRSF3 as an essential regulator of alternative splicing and of transposable elements to maintain transcriptome integrity in mouse oocyte. Using 3D time-lapse confocal live imaging, we show that conditional deletion of Srsf3 in fully grown germinal vesicle oocytes substantially compromises the capacity of germinal vesicle breakdown (GVBD), and consequently entry into meiosis. By combining single cell RNA-seq, and oocyte micromanipulation with steric blocking antisense oligonucleotides and RNAse-H inducing gapmers, we found that the GVBD defect in mutant oocytes is due to both aberrant alternative splicing and derepression of B2 SINE transposable elements. Together, our study highlights how control of transcriptional identity of the maternal transcriptome by the RNA-binding protein SRSF3 is essential to the development of fertilized-competent oocytes.
Krüppel-Like Factor 10 participates in cervical cancer immunoediting through transcriptional regulation of Pregnancy-Specific Beta-1 Glycoproteins
Authors: Marrero-Rodríguez Daniel , Taniguchi-Ponciano Keiko , Subramaniam Malayannan , Hawse John R. , Pitel Kevin S. , Arreola-De la Cruz Hugo , Huerta-Padilla Victor , Ponce-Navarrete Gustavo , Figueroa-Corona Ma. del Pilar , Gomez-Virgilio Laura , Martinez-Cuevas Teresa I. , Mendoza-Rodriguez Monica , Rodriguez-Esquivel Miriam , Romero-Morelos Pablo , Ramirez-Salcedo Jorge , Baudis Michael , Meraz-Rios Marco , Jimenez-Vega Florinda , Salcedo Mauricio 
Published: June 2018

AbstractCervical cancer (CC) is associated with alterations in immune system balance, which is primarily due to a shift from Th1 to Th2 and the unbalance of Th17/Treg cells. Usingin silicoDNA copy number analysis, we have demonstrated that ~20% of CC samples exhibit gain of 8q22.3 and 19q13.31; the regions of the genome that encodes the KLF10 and PSG genes, respectively. Gene expression studies demonstrated that there were no alterations in KLF10 mRNA expression, whilst the PSG2 and −5 genes were up-regulated by 1.76 and 3.97-fold respectively in CC compared to normal tissue controls. siRNA and ChIP experiments in SiHa cells have demonstrated that KLF10 participates in immune response through regulation of IL6, IL25 and PSG2 and PSG5 genes. Using cervical tissues from KLF10−/−mice, we have identified down-regulation of PSG17, −21 and −23 and IL11. These results suggest that KLF10 may regulate immune system response genes in cervical cancer among other functions. KLF10 and PSG copy number variations and alterations in mRNA expression levels could represent novel molecular markers in CC.
Autoimmune disease associated IFIH1 single nucleotide polymorphism related with IL-18 serum levels in Chinese systemic lupus erythematosus patients
Authors: Zhang Junlong , Liu Xinle , Meng Yanming , Wu Hengxu , Wu Yongkang , Yang Bin , Wang Lanlan 
Published: June 2018

AbstractSystemic lupus erythematosus (SLE) has heterogeneous clinical manifestations. IFIH1 (interferon induced with helicase C domain 1) as one of antiviral helicase genes mediating type I interferon production, plays an essential role in the pathogenesis of SLE. The gene variants in IFIH1 could abnormally activate antiviral defenses and increased type I interferon signaling. The present study aimed to validate associations between single nucleotide polymorphisms (SNP) in IFIH1 and the pathogenesis of SLE. In total, rs1990760, rs3747517 and rs10930046 in IFIH1 are genotyped in 400 SLE patients and 659 health controls in Chinese cohort by an improved multiplex ligation detection reaction (iMLDR) technique. Significant associations were observed between alleles of IFIH1 (rs1990760 C > T, P = 0.005, OR = 1.36, 95%CI = 1.10–1.69; rs3747517 T > C, P = 0.004, OR = 1.31, 95%CI = 1.09–1.58, respectively) and SLE susceptibility. IFIH1 rs1990760 TT genotype carriers had lower serum levels of IL-18 (P < 0.001) and granzyme B (P < 0.001) than CC and CT genotype carriers. IFIH1 rs1990760 CT genotype carriers had higher anti-dsDNA–positive than CC and TT genotype carriers. In conclusion, IFIH1 polymorphisms (rs1990760 and rs3747517) were associated with SLE susceptibility and rs1990760 risk T allele related with IL-18 and granzyme B serum levels in SLE patients.
Transient and Flexible Hyperbolic Metamaterials on Freeform Surfaces
Authors: Lin Hung-I , Shen Kun-Ching , Lin Shih-Yao , Haider Golam , Li Yao-Hsuan , Chang Shu-Wei , Chen Yang-Fang 
Published: June 2018

AbstractTransient technology is deemed as a paramount breakthrough for its particular functionality that can be implemented at a specific time and then totally dissolved. Hyperbolic metamaterials (HMMs) with high wave-vector modes for negative refraction or with high photonic density of states to robustly enhance the quantum transformation efficiency represent one of the emerging key elements for generating not-yet realized optoelectronics devices. However, HMMs has not been explored for implementing in transient technology. Here we show the first attempt to integrate transient technology with HMMs, i.e., transient HMMs, composed of multilayers of water-soluble and bio-compatible polymer and metal. We demonstrate that our newly designed transient HMMs can also possess high-k modes and high photonic density of states, which enables to dramatically enhance the light emitter covered on top of HMMs. We show that these transient HMMs devices loss their functionalities after immersing into deionized water within 5 min. Moreover, when the transient HMMs are integrated with a flexible substrate, the device exhibits an excellent mechanical stability for more than 3000 bending cycles. We anticipate that the transient HMMs developed here can serve as a versatile platform to advance transient technology for a wide range of application, including solid state lighting, optical communication, and wearable optoelectronic devices, etc.
Patch Angioplasty or Primary Closure Following Carotid Endarterectomy for Symptomatic Carotid Artery Stenosis
Authors: Huizing Eline , Vos Cornelis , Hulsebos Robin , van den Akker Peter , Borst Gert , Ünlü Çağdaş 
Published: June 2018

Objectives Guidelines recommend routine patching to prevent restenosis following carotid endarterectomy, mainly based on studies performed many years ago with different perioperative care and medical treatment compared with current standards. Aim of the present study was to compare primary closure (PRC) versus patch closure (PAC) in a contemporary cohort of patients.
Methods Consecutive patients treated by carotid endarterectomy for symptomatic stenosis between January 2006 and April 2016 were retrospectively analyzed. Primary outcome was restenosis at 6 weeks and 1 year and occurrence of ipsilateral stroke. Secondary outcomes were mortality, complications, and reintervention rates.
Results Five hundred carotid artery endarterectomies were performed. Fifty-nine patients were excluded because eversion endarterectomy was performed or because they were asymptomatic. PRC was performed in 349 and PAC in 92 patients. Restenosis at 6 weeks was 6.0% in the PAC group versus 3.0% in the PRC group (p = 0.200). Restenosis at 1 year was 31.6 versus 14.1%, respectively (p = 0.104). No difference was found for stroke (3.4 vs 1.1%, p = 0.319), death (1.1 vs 0.0%, p = 0.584), or other complications (1.1 vs 0.0%, p = 0.584), respectively.
Conclusions It remains unclear whether routine patching should be recommended for all patients. A strategy of selective patching compared with routine patching, based on internal carotid artery diameter and other patient characteristics, deserves further investigation.
Diffusiophoresis of charged colloidal particles in the limit of very high salinity
Authors: Prieve Dennis C. , Malone Stephanie M. , Khair Aditya S. , Stout Robert F. , Kanj Mazen Y. 
Published: June 2018

Significance
Contact between low- and high-salinity water occurs in many applications including enhanced oil recovery (EOR), desalination by reverse osmosis, or electric-power production (“blue energy”) by pressure-retarded osmosis. The resulting salinity gradients can propel particles which cause fouling of osmosis membranes. In EOR the gradient can transport functionalized nanoparticles into the porous oil-bearing rock. Once transported, the nanoparticles undertake in situ sensing and intervention activities in the rock. At very high salinity, the long-range interaction needed for diffusiophoresis or electrophoresis of charged particles is expected to vanish. Nonetheless, we observed measurable speeds at salinities approaching saturation.
A disordered acidic domain in GPIHBP1 harboring a sulfated tyrosine regulates lipoprotein lipase
Authors: Kristensen Kristian K. , Midtgaard Søren Roi , Mysling Simon , Kovrov Oleg , Hansen Lars Bo , Skar-Gislinge Nicholas , Beigneux Anne P. , Kragelund Birthe B. , Olivecrona Gunilla , Young Stephen G. , Jørgensen Thomas J. D. , Fong Loren G. , Ploug Michael 
Published: June 2018

Significance
Dietary fats absorbed by intestinal enterocytes are packaged into chylomicrons, which circulate in the bloodstream until docking along capillary endothelial cells, primarily in striated muscle and adipose tissue. There, a functional unit composed of lipoprotein lipase (LPL) and GPIHBP1 hydrolyzes the triglycerides in chylomicrons, releasing free fatty acids for use by surrounding parenchymal cells. The current study describes the interactions between LPL and GPIHBP1 and describes how a disordered region of GPIHBP1 results in order and functional stability within LPL. The elucidation of LPL–GPIHBP1 interactions sheds light on the regulation of intravascular triglyceride processing and provides insights into plasma triglyceride metabolism in health and disease.
Update on the genetics of nonbacterial osteomyelitis in humans
Authors: Cox Allison J. , Ferguson Polly J. 
Published: June 2018

Purpose of review
To summarize the current advances in our understanding or the genetic basis of nonbacterial osteomyelitis.

Recent findings
Chronic recurrent multifocal osteomyelitis (CRMO) is a complex genetic disorder. Past discoveries identified several single gene defects (LPIN2, Pstpip2 and IL1RN) that cause IL-1-mediated sterile multifocal osteomyelitis. Recently Lorden et al.'s studies show that LIPIN2 deficiency can activate the NLRP3 inflammasome through alterations in the function of P2X7 receptor providing evidence that Majeed syndrome is an NLRP3 inflammasomopathy. New gene discoveries include the identification of FBLIM1 as a CRMO susceptibility gene. Mutations in FBLIM1 were found in a consanguineous family with CRMO. Fblim1 is one of the most significantly differentially expressed gene in bone from chronic multifocal osteomyelitis (cmo) mice, plays a role in IL-10-driven anti-inflammatory responses, and is involved in the physiology of bone remodeling. Lastly, new data on the putative CRMO susceptibility locus on chromosome 18 is presented here. Using Sanger sequencing, rather than microsatellite analysis, the DS18S60 susceptibility region could not be replicated in a larger cohort.

Summary
CRMO occurs in humans, nonhuman primates, dogs and mice. There is a genetic component to disease but the genetic basis has only been identified for a small percentage of all cases.
MULTIMODAL IMAGING IN A CASE OF CENTRAL RETINAL ARTERY OCCLUSION IN THE PRESENCE OF TYPE 2 MACULAR TELANGIECTASIA
Authors: Ingolotti Mariana , Roig Melo-Granados Enrique Alfonso , González-Madrigal Pedro Mario , Ruiz García Humberto 
Published: June 2018

Purpose:
To report a case of central retinal artery occlusion in a patient with macular telangiectasia Type 2 using multimodal imaging.

Methods:
Observational case report.

Results:
A 58-year-old woman who presented with acute painless unilateral vision loss was diagnosed with central retinal artery occlusion in her right eye with macular telangiectasia Type 2 findings in both eyes. Fundus examination revealed retinal whitening with unusual cherry-red spot plus small crystalline deposits in the temporal macula. Surprisingly, spectral domain optical coherence tomography of the contralateral eye showed characteristically intraretinal hyporreflective spaces, whereas optical coherence tomography angiography exhibited microvascular abnormalities in the deep capillary plexus. At follow-up, a pseudolamellar macular hole was noticed in the affected eye with no recovery of best-corrected visual acuity.

Conclusion:
This case describes an onset of central artery occlusion in a patient with underlying macular telangiectasia Type 2 and suggests that it had a possible role in the acceleration of its natural course. The utility of multimodal imaging lies on better accuracy in diagnosis as well as prognosis, management, and monitoring of the disease.
Analysis of Clozapine Use and Safety by Using Comprehensive National Data From the Japanese Clozapine Patient Monitoring Service
Authors: Inada Ken , Oshibuchi Hidehiro , Ishigooka Jun , Nishimura Katsuji 
Published: June 2018

Abstract

Objective
The aim of this study was to investigate clozapine use and its associated adverse effects in patients in Japan.

Methods
We analyzed data recorded from July 2009 to January 2016 (N = 3780 patients) in the Clozaril Patient Monitoring Service, which was established in Japan in 2009 and includes all Japanese patients who have been prescribed clozapine.

Results
The treatment discontinuation rate was 23.9% (869/3780 cases). The average ± SD treatment duration was 234.9 ± 306.9 days (median, 115 days), and the average ± SD dosage was 186.41 ± 151.6 mg/d. The estimated treatment continuation rates resulting from all-cause discontinuation were 78.2 after 1 year and 72.9% after 2 years of treatment. The incidence of neutropenia/leucopenia was 5.4% (206/3780 cases). The average ± SD dose before discontinuation was 233.36 ± 168.15 mg (median, 200 mg; range, 4–600 mg). The incidence of glucose intolerance was 15.4% (583/3780 cases). Of 3780 patients, 98 (2.67%) developed glucose intolerance before and after taking clozapine administration, whereas 485 patients (12.8%) developed glucose intolerance after taking clozapine. The average ± SD time from treatment initiation to new onset of glucose intolerance was 382.2 ± 420.2 days (median, 216 days; range, 4–2053 days).

Conclusions
The data obtained in this study, particularly regarding the incidence of clozapine-induced adverse events, will enable the optimal and safe use of clozapine in Japanese patients with treatment-resistant schizophrenia.
Current Practices in Pediatric Emergency Medicine Fellowship Trauma Training
Authors: Fleisher Diana T. , Katz-Sidlow Rachel J. , Meltzer James A. 
Published: June 2018

Objective
The management of injured children is a required element of pediatric emergency medicine (PEM) fellowship training. Given the relatively infrequent exposure of trainees to major trauma, it is important to understand how programs train fellows and assess their competency in pediatric trauma.

Methods
An online survey was sent to 84 PEM fellowship program directors (PDs). Program directors were asked to describe their program's characteristics, the degree of fellow independence, educational techniques used to train fellows in trauma, and their expectation of fellows' competency in 14 core trauma-related skills upon graduation. Program directors were classified as having high expectations if they anticipated that graduating fellows could perform 12 trauma skills or more independently.

Results
Fifty-nine programs (70%) responded. Although most programs (55, 93%) identified as pediatric trauma centers, fellows at the majority of programs (41, 69%) spent some or all of their trauma experience at an outside hospital. Only a minority of programs (17, 29%) allowed fellows to lead pediatric trauma resuscitations as independent attendings without precepting. Programs used over a dozen different educational methods to varying degrees. Less than half of programs (28, 47%) used a formal trauma curriculum. Whereas 33 PDs (56%) had high expectations, only 9 (15%) expected fellows to be able to perform all 14 skills.

Conclusions
There is considerable variability in how PEM fellows are trained to care for injured children. Most PDs do not realistically expect fellows to be able to perform all recommended trauma skills after graduation. Our findings highlight the need for further research and efforts to standardize the training of PEM fellows in pediatric trauma.