bluuebunny/crossref_metadata_2025_split huggingface dataset:
Results of catheter-directed thrombolysis for acute ilio-femoral deep venous thrombosis – A retrospective cohort study
Authors: Madsen Christina P , Gesla Jerzy , Vijdea Radu L , Serifi Maria A , Christensen Johnny K , Houlind Kim 
Published: March 2018

Background Catheter-directed thrombolysis may prevent post-thrombotic syndrome in patients with ilio-femoral deep venous thrombosis. We performed a retrospective review of prospectively collected follow-up data to evaluate the results of catheter-directed thrombolysis at our institution. Method Patients admitted for venous thrombolysis were included in the study and their files screened for information regarding results and technical aspects of treatment and patient status on follow-up. A catheter was inserted under imaging guidance into the thrombosed vein. Through the catheter tissue plasminogen activator was administered. Daily catheter-based venographies were performed to monitor progression in thrombus resolution. After thrombolysis flow-limiting stenosis was stented. Patients started wearing compression stockings and were started on oral anticoagulant therapy. Follow-up visits with ultrasound, magnetic resonance venography and clinical assessment were scheduled at six weeks and three, six, 12 and 24 months. Results A total of 48 patients underwent catheter-directed thrombolysis, including 36 female patients. Median age was 28 years. Complete lysis of the thrombus was achieved in 43 cases and partial lysis in two cases and 26 stents were placed. No deaths or life-threatening bleeding events occurred. Thirty-two of the patients who achieved full lysis and were followed up remained patent at follow-up. At 12 months seven patients had symptoms of post-thrombotic syndrome. Conclusion Catheter-directed thrombolysis represents a safe and effective alternative to systemic anticoagulative treatment of deep venous thrombosis with rapid resolution of the thrombus and few complications. Long-term patency shows good validity and this study suggests that catheter-directed thrombolysis is effective in preventing post-thrombotic syndrome.
Real‐world management of juvenile autoimmune liver disease
Authors: de Boer Y S , Liberal R , Vergani D , Mieli-Vergani G 
Published: March 2018

Background and aimsJuvenile autoimmune liver disease (JAILD) includes paediatric forms of autoimmune hepatitis (AIH) and autoimmune sclerosing cholangitis (ASC). Since evidence is scarce, there are currently no evidence‐based management guidelines for juvenile AIH. This survey was carried out amongst the paediatric members of the International AIH Group (IAIHG) to describe their practices in the management of JAILD.MethodsAn online survey questionnaire was distributed to members of the IAIHG with active practice (https://www.surveymonkey.de/r/Juvenile_AILD). The questionnaire consisted of four clinical scenarios on different presentations of AIH.ResultsFifty‐eight surveys were sent to the IAIHG members, out of which 43 (74%, 22 countries, four continents) were returned. None reported budesonide as a first‐line induction agent for the acute presentation of AIH. Sixteen (37%) routinely perform liver biopsy at three years of biochemical remission. Thirty‐five respondents (81%) perform magnetic resonance cholangiography (MRC) at presentation. Ciclosporin is the most widely used second‐line agent (number of patients treated = ∼360, 21 centres). Mycophenolate mofetil (n = ∼225, 31 centres), tacrolimus (n = ∼130, 21 centres) and sirolimus (n = ∼5, 3 centres) are less often reported. Rescue therapy with infliximab and rituximab has been tried in eight centres (n = ∼19) and nine centres (n = ∼16), respectively.ConclusionsPrednisolone remains the preferred first‐line induction agent in JAILD. MRC at presentation is performed by the large majority of participants. Participants reported a wide variation in performing liver biopsy for therapy evaluation during follow‐up. Within the paediatric members of the IAIHG there is considerable experience with second‐line therapeutic agents.
Examining Trends in Cost and Clinical Benefit of Novel Anticancer Drugs Over Time
Authors: Saluja Ronak , Arciero Vanessa S. , Cheng Sierra , McDonald Erica , Wong William W.L. , Cheung Matthew C. , Chan Kelvin K.W. 
Published: March 2018

Purpose: The purpose of this study was to determine if clinical benefits of novel anticancer drugs, measured by the ASCO Value Framework and European Society of Medical Oncology (ESMO) Magnitude of Clinical Benefit Scale, have increased over time in parallel with increasing costs. Methods: Anticancer drugs from phase III randomized controlled trials cited for clinical efficacy evidence in drug approvals between January 2006 to December 2015 were identified and scored using both frameworks. For each drug, the monthly price and incremental anticancer drug costs were calculated. Relationships between cost and year of approval were examined using generalized linear regressions models. Ordinary least square models were used to evaluate relationships between ASCO and ESMO scores and year of approval. Spearman correlation coefficients between costs and clinical benefit scores were calculated. Results: In total, 42 randomized controlled trials were included. Both monthly prices and incremental anticancer drug costs were significantly associated with year of approval and showed an average annual increase of 9% and 21%, respectively. The predicted mean incremental anticancer drug cost increased from $30,447 in 2006 to $161,141 in 2015 (greater than five-fold increase). Both ASCO and ESMO scores were not statistically associated with year of approval or correlated with monthly prices or incremental anticancer drug costs. Conclusion: Over the past decade, costs of novel oncology drugs have increased, while clinical benefits of these medications have not experienced a proportional positive change. The incremental anticancer drug costs have increased at a much greater rate than monthly prices, indicating that the increase in anticancer drug costs may be higher than commonly reported.
A Self-Fulfilling Cycle of Coercive Surveillance: Workers’ Invisibility Practices and Managerial Justification
Authors: Anteby Michel , Chan Curtis K. 
Published: March 2018

In the past few decades, the growth of surveillance has become a fixture of organizational life. Past scholarship has largely explained this growth as the result of traditional managerial demands for added control over workers, coupled with newly available cheap technology (such as closed-circuit televisions and body-worn cameras). We draw on the workplace resistance literature to complement these views by suggesting that workers can also drive such growth. More specifically, we show that workers under surveillance can feel constantly observed and seen, but they can also feel largely unnoticed as individuals by management. This paradoxical experience leads them to interpret the surveillance as coercive and to engage in invisibility practices to attempt to go unseen and remain unnoticed. Management, in turn, interprets these attempts as justification for more surveillance, which encourages workers to engage in even more invisibility practices, thus creating a self-fulfilling cycle of coercive surveillance. Our study therefore offers one of the first endogenous explanations for the growth of surveillance while also isolating unique forms of resistance attached to such surveillance.The e-companion is available at https://doi.org/10.1287/orsc.2017.1175 .
The Effects of Communication Networks and Turnover on Transactive Memory and Group Performance
Authors: Argote Linda , Aven Brandy L. , Kush Jonathan 
Published: March 2018

We theorize that the effect of membership turnover on group processes and performance depends on a group’s communication network. We describe two mechanisms through which communication networks affect group performance: (1) the number of direct communication paths and (2) the clarity of the coordination logic. These mechanisms map onto two network dimensions: density, which affects a group’s behavior through the number of available communication paths, and centralization, which affects a group’s behavior through the clarity of the coordination logic. We empirically analyze the effects of turnover on the performance of fully connected all-channel networks and hub-and-spoke or wheel networks in an experiment of 109 four-person groups performing two collaborative problem-solving tasks. The greater number of direct communication paths enabled fully connected groups with stable membership to develop stronger transactive memory systems (TMSs) and perform better than fully connected groups that experienced turnover. By contrast, the clear coordination logic of perfectly centralized groups that experienced turnover facilitated more frequent dyadic communication, which enabled them to strengthen their TMSs, incorporate the contributions of new members, and improve their performance. Thus, our results indicate that communication networks condition the effect of membership turnover on group processes and performance. The online appendix is available at https://doi.org/10.1287/orsc.2017.1176 .
Self-care strategies to prevent venous leg ulceration recurrence
Authors: Brown Annemarie 
Published: March 2018

Recurrence of venous leg ulcers is common. Annemarie Brown discusses self-care strategies that can play a role in the prevention of recurrence Venous leg ulcers are common and take a long time to heal. Recurrence of leg ulcers occurs frequently, with some estimates suggesting 70% of ulcers will recur. Preventing recurrence would reduce costs to the NHS, as well as improve quality of life for patients. Encouraging patients to self-care is key to preventing recurrence of venous leg ulcers. Self-care includes the use of compression therapy, physical activity, mobility and leg elevation. It is likely that practice nurses will be responsible for encouraging patients to perform self-care in order to prevent venous leg ulcer recurrence.
The rock band KISS and American Dream ideology
Authors: James Kieran , Briggs Susan P. , Grant Bligh 
Published: March 2018

Abstract
This article is a collective effort on the authors’ part to remember KISS, one of the most important hard-rock bands of the 1970s and 1980s. Influenced by the glam-rock movement that preceded its rise, arguably KISS was the first major act in rock music history to present rock music as Entertainment Product first and music only second. We discuss the original, democratic concept of the Fab Four – Gene, Paul, Ace and Peter – as well as Gene Simmons’ and Paul Stanley’s subsequent American Dream ideology. We go on to analyse the current version of the band in the light of the original line-up and appearance. We find that the KISS fan base is divided with some fans accepting Simmons’ current view that the four masked personas can be utilized by anyone chosen by the band’s leadership; a second group that tries to correct the alleged historical injustices committed against former band members Ace Frehley and Peter Criss; and a third group that is cynical about the current version of KISS but finds it fruitless to rehash old debates (since any proffered solutions not supported by the current band leadership are unlikely to come to pass).
The Current Use of GPS, Its Potential, and Limitations in Soccer
Authors: Hennessy Liam , Jeffreys Ian 
Published: March 2018

ABSTRACT
IN SOCCER, GLOBAL POSITIONING SYSTEM (GPS) MONITORING OF PLAYER WORKLOADS IS NOW EXTENSIVELY USED ACROSS ALL LEVELS OF THE SPORT. TO MAKE BETTER USE OF THIS TECHNOLOGY IT IS IMPORTANT TO APPRECIATE HOW IT WORKS. FURTHER, WHEN THE LIMITATIONS OF GPS USE ARE APPRECIATED AND THE RATIONALE OF USE IS AGREED AND ARTICULATED, THEN THE POTENTIAL OF GPS MONITORING CAN BE EFFECTIVELY REALIZED TO BETTER MANAGE PLAYERS' PERFORMANCE, WORKLOAD AND WELFARE. (SEE VIDEO, SUPPLEMENTARY DIGITAL CONTENT, NUMBER 1, WHICH SUMMARIZES GPS USE, LIMITATIONS, AND POTENTIAL IN SOCCER, HTTP://LINKS.LWW.COM/SCJ/A238).
Differences in the Electrophysiological Properties of Mouse Somatosensory Layer 2/3 NeuronsIn Vivoand Slice Stem from Intrinsic Sources Rather than a Network-Generated High Conductance State
Authors: Fernandez Fernando R. , Rahsepar Bahar , White John A. 
Published: March 2018

AbstractSynaptic activityin vivocan potentially alter the integration properties of neurons. Using recordings in awake mice, we targeted somatosensory layer 2/3 pyramidal neurons and compared neuronal properties with those from slices. Pyramidal cellsin vivohad lower resistance and gain values, as well as broader spikes and increased spike frequency adaptation compared to the same cells in slices. Increasing conductance in neurons using dynamic clamp to levels observedin vivo, however, did not lessen the differences betweenin vivoand slice conditions. Further, local application of tetrodotoxin (TTX)in vivoblocked synaptic-mediated membrane voltage fluctuations but had little impact on pyramidal cell membrane input resistance and time constant values. Differences in electrophysiological properties of layer 2/3 neurons in mouse somatosensory cortex, therefore, stem from intrinsic sources separate from synaptic-mediated membrane voltage fluctuations.
Genome-Wide Analysis ofMycoplasma bovirhinisGS01 Reveals Potential Virulence Factors and Phylogenetic Relationships
Authors: Chen Shengli , Hao Huafang , Zhao Ping , Liu Yongsheng , Chu Yuefeng 
Published: March 2018

AbstractMycoplasma bovirhinis is a significant etiology in bovine pneumonia and mastitis, but our knowledge about the genetic and pathogenic mechanisms of M. bovirhinis is very limited. In this study, we sequenced the complete genome of M. bovirhinis strain GS01 isolated from the nasal swab of pneumonic calves in Gansu, China, and we found that its genome forms a 847,985 bp single circular chromosome with a GC content of 27.57% and with 707 protein-coding genes. The putative virulence determinants of M. bovirhinis were then analyzed. Results showed that three genomic islands and 16 putative virulence genes, including one adhesion gene enolase, seven surface lipoproteins, proteins involved in glycerol metabolism, and cation transporters, might be potential virulence factors. Glycerol and pyruvate metabolic pathways were defective. Comparative analysis revealed remarkable genome variations between GS01 and a recently reported HAZ141_2 strain, and extremely low homology with others mycoplasma species. Phylogenetic analysis demonstrated that M. bovirhinis was most genetically close to M. canis, distant from other bovine Mycoplasma species. Genomic dissection may provide useful information on the pathogenic mechanisms and genetics of M. bovirhinis.
Genome-Wide Association Mapping Uncovers Fw1, a Dominant Gene Conferring Resistance to Fusarium Wilt in Strawberry
Authors: Pincot Dominique D A , Poorten Thomas J , Hardigan Michael A , Harshman Julia M , Acharya Charlotte B , Cole Glenn S , Gordon Thomas R , Stueven Michelle , Edger Patrick P , Knapp Steven J 
Published: March 2018

Abstract
Fusarium wilt, a soil-borne disease caused by the fungal pathogen Fusarium oxysporum f. sp. fragariae, threatens strawberry (Fragaria × ananassa) production worldwide. The spread of the pathogen, coupled with disruptive changes in soil fumigation practices, have greatly increased disease pressure and the importance of developing resistant cultivars. While resistant and susceptible cultivars have been reported, a limited number of germplasm accessions have been analyzed, and contradictory conclusions have been reached in earlier studies to elucidate the underlying genetic basis of resistance. Here, we report the discovery of Fw1, a dominant gene conferring resistance to Fusarium wilt in strawberry. The Fw1 locus was uncovered in a genome-wide association study of 565 historically and commercially important strawberry accessions genotyped with 14,408 SNP markers. Fourteen SNPs in linkage disequilibrium with Fw1 physically mapped to a 2.3 Mb segment on chromosome 2 in a diploid F. vesca reference genome. Fw1 and 11 tightly linked GWAS-significant SNPs mapped to linkage group 2C in octoploid segregating populations. The most significant SNP explained 85% of the phenotypic variability and predicted resistance in 97% of the accessions tested—broad-sense heritability was 0.96. Several disease resistance and defense-related gene homologs, including a small cluster of genes encoding nucleotide-binding leucine-rich-repeat proteins, were identified in the 0.7 Mb genomic segment predicted to harbor Fw1. DNA variants and candidate genes identified in the present study should facilitate the development of high-throughput genotyping assays for accurately predicting Fusarium wilt phenotypes and applying marker-assisted selection.
Феномен гендерной метаморфозы в романе А. Картер «Страсть новой Евы»
Authors: Семенец Антонина Валерьевна 
Published: March 2018

<p>Статья посвящена рассмотрению феномена гендерной метаморфозы на примере романа английской писательницы ХХ в. Анджелы Картер «Страсть новой Евы» (1977). Мотив разного рода превращений свойственен широкому кругу произведений разных авторов, поэтому данное явление анализируется во взаимосвязи с другими художественными текстами.</p><p>Трансформации можно рассматривать как фантастические элементы, создающие такие нарративы, в которых повествование может быть подвергнуто деконструкции или извращаться. Метаморфоза, или превращение, переход, принятие новой формы с изменением внешнего вида, влечет за собой разрыв связей между телом и сознанием, которые были достаточно крепки и естественны. Отмечено, что сюжеты, связанные с превращениями, сформированы под влиянием мифологии, философии и фольклора. </p><p>В работе выделены как общие черты сюжетообразующего начала метаморфозы в романе А. Картер, так и ее особенности, к которым можно прежде всего отнести феминистскую направленность. Рассмотрены образы Евы/Эвелина и Тристессы как примеры гендерной нестабильности. Их неординарность отображает позицию автора, что гендер имеет социальную природу и ему свойственна динамичность.</p>Современные теории идентичности катализируют дискуссии феминистского характера, они также расширили теоретическую базу, ставшую основой творчества А. Картер. Литературная интертекстуальность ее работ указывает на осведомленность и интерес писательницы к интерпретациям идентичности и гендера, базирующимся на теориях психоанализа и феминизма. А. Картер, используя литературные приемы, не только подвергает критике стереотипы, выработанные современным обществом, но и разрабатывает гендерную проблематику. Такая писательская стратегия позволяет автору находить все новые ключи к расширению человеческой свободы
Connective tissue dysplasia in females with primary knee and hip osteoarthritis
Authors: Izmozherova N V , Getmanova N A , Popov A A , Peretolchina T F 
Published: March 2018

Aim. Assessment of the prevalence of connective tissue dysplasia markers in women with primary knee and hip osteoarthritis.
Methods. 203 females were examined in a cross-sectional study, with median age 58 years (55-62 years) and duration of post-menopause for 8 years (5.0-12.0 years). Severity of postmenopausal syndrome was defined by modified menopause index scores with the assessment of neurovegetative, metabolic and endocrine and psychoemotional symptoms. Backache and joint pain were assessed by visual analogue scale. Osteoarthritis was diagnosed according to clinical and radiologic criteria.
Results. In 153 patients primary osteoarthritis stage 2-3 was diagnosed (group 1), group 2 included 50 patients without osteoarthritis. Screening for connective tissue dysplasia was performed by steps. At first, L.V. Solovyova’s phenotypic screening scale modified by T.F. Peretolchina was used, and cut-off score of 1.92 points was found in 6 (12%) patients without osteoarthritis and 44 (28.8%) in osteoarthritis group, that allowed suggesting connective tissue dysplasia. Then international M.J. Glesby phenotypic scale was used: 53 (34.6%) patients with osteoarthritis and only 1 (2%) subject without osteoarthritis had three and more phenotypic traits (χ2=18.925, р <0.001), that confirms connective tissue dysplasia. On step three, according to Russian guidelines on «Inherited disorders of connective tissue» (Russian scientific society of cardiology, 2012), among examined patients three phenotypes of connective tissue dysplasia were determined: (1) joint hypermobility syndrome; (2) increased dysplastic stigmatization and (3) increased, mostly visceral dysplastic stigmatization. The latter was more prevalent in females with osteoarthritis.
Conclusion. High prevalence of connective tissue dysplasia criteria in primary osteoarthritis patients confirms the presence of dysplastic osteoarthritis phenotype and necessity of personalized attitude to patient management.
Efficacy of magneto-laser therapy in the treatment of ureaplasma infection
Authors: Aliev N N , Zeynalov M S , Alieva N N 
Published: March 2018

Aim. To study clinical and epidemiological data in males and females with ureaplasma infection and to evaluate efficacy of magneto-laser therapy used as additional treatment of ureaplasma infection.
Methods. 104 patients (94 men and 10 women) with urogenital ureaplasma infection were observed. Patients were divided into two groups: a study group (n=55) that received standard and magneto-laser therapy, and a comparison group (n=49) that received only standard treatment. Polymerase chain reaction was used to investigate samples for Mycoplasma hominis, Ureaplasma parvum and urealyticum, and bacteriological study for Mycoplasma hominis and Ureaplasma spp. was additionally performed with determining their antibiotic susceptibility. Magnetic therapy was conducted with the use of Michelangelo device (Italy) for 10 minutes to small pelvis area for 10 days.
Results. As a result, 78 (82.9%) males were diagnosed with uretritis, 52 (55.3%) with prostatitis, 37 (39.3%) with cystitis. In females monoinfection was more prevalent than in males (50.0% vs 40.4%). Ureaplasmosis predominantly affected subjects aged 20-29 (97.8%) and 30-39 (86.0%) years. In female group, patients aged 20-29 years prevailed, while in a male group - patients aged 30-39 years. In males, the association of Ureaplasma with Mycoplasma hominis (36.1%) prevailed.
Conclusion. Complex treatment of ureaplasma infection of urogenital tract including magneto-laser therapy demonstrated high clinical efficacy and allowed achieving clinical and laboratory cure of ureaplasma infection in 85.4% of cases.