bluuebunny/crossref_metadata_2025_split huggingface dataset:
Adult Bone Marrow Three‐Dimensional Phenotypic Landscape of B‐Cell Differentiation
Authors: Carrion Claire , Guérin Estelle , Gachard Nathalie , le Guyader Alexandre , Giraut Stéphane , Feuillard Jean 
Published: November 2018

BackgroundThe different B‐cell subsets in human bone marrow result from a dynamic equilibrium between endogenous production, B‐cell bone marrow reentry and terminal plasma cell differentiation. Our aim was to define and quantify the different medullary B‐cell subsets.MethodsA series of 32 normal adult bone marrows plus 15 normal adult blood samples was studied by nine color flow cytometry (CD10, CD19, CD24, CD27, CD34, CD38, CD45, IgM, and IgD). With the Kaluza software radar plots, two 2D triple parametric histograms (CD10/CD34/CD45 and CD27/IgM/IgD) were set‐up to identify six progenitor and five mature B‐cell subsets.ResultsVery early B‐cell progenitors were CD19neg/CD10pos/CD34pos. B‐cell progenitors were split into five subsets on the CD10/CD34/CD45 triple parametric histogram, sequentially ordered according to the loss of CD34 and CD10 and acquisition of surface IgM and IgD. CD19pos/CD38low mature B‐cells were divided into four subsets on the CD27/IgM/IgD triple parametric histogram, with two stages of naïve B‐cells and two CD27hi marginal zone and switched memory B‐cell compartments. CD19pos/CD34neg/CD10low immature B‐cells were the main bone marrow B‐cell subset, accounting for one third of bone marrow B‐cells. Transitional B‐cells were the only immature bone marrow stage found in the blood. Compared to blood, the bone marrow was enriched in both marginal zone and switched B‐cells.ConclusionWe provide the first analysis of 3D B‐cell differentiation by multicolor flow cytometry leading to propose reference values for each bone marrow and blood B‐cell compartment. This warrants further exploration of normal and pathological human B‐cell maturation. © 2018 International Clinical Cytometry Society
Fundamental study on fatigue measurement in VDT work from speech analysis
Authors: Matsumura Toshie , Kawamura Emi , Kosaka Hiroaki , Hashimoto Hideki , Kagawa Toshiya , Yoshimura Hiroki , Shimizu Tadaaki 
Published: November 2018

AbstractWe aimed at developing a simple fatigue measurement system, so far the influence of the noise is small under laboratory environment and the experimenter side who uses a simulator. We have been studying fatigue measurement in a manageable environment. In order to show the effectiveness of our proposed method in a real environment, we collected fatigue measurement indexes before and after work for technical engineers of Software Development Company operating visual display terminals (VDT) work, changes before and after were compared and examined. As a result, in the conventional indexes, a significant difference was found in the pulse rate and the flicker value. We found that there are significant differences between before and after some speech of fundamental frequency, speech power, and period of speech indexes. In VDT work, there was a difference in flicker value as a fatigue measurement index, which was also supported by subjective symptoms and self‐evaluation results. In addition, since significant differences were also found in the speech index, in the work centering on the VDT work as well as the bicycle simulator so far, it was shown that speech indexes can be effective indicators.
Diastolic stress test echocardiography in patients with suspected heart failure with preserved ejection fraction: a pilot study
Authors: Belyavskiy Evgeny , Morris Daniel A. , Url‐Michitsch Marion , Verheyen Nicolas , Meinitzer Andreas , Radhakrishnan Aravind‐Kumar , Kropf Martin , Frydas Athanasios , Ovchinnikov Artem G. , Schmidt Albrecht , Tadic Marijana , Genger Martin , Lindhorst Ruhdja , Bobenko Anna , Tschöpe Carsten , Edelmann Frank , Pieske‐Kraigher Elisabeth , Pieske Burkert 
Published: November 2018

AbstractAimsThe purpose of this pilot study was to assess the potential usefulness of diastolic stress test (DST) echocardiography in patients with suspected heart failure with preserved ejection fraction (HFpEF).Methods and resultsPatients with suspected HFpEF (left ventricular ejection fraction ≥ 50%, exertional dyspnoea, septal E/e′ at rest 9–14, and N‐terminal pro‐B‐type natriuretic peptide (NT‐proBNP) at rest < 220 pg/mL; n = 13) and a control group constituted from asymptomatic patients with arterial hypertension (n = 19) and healthy subjects (n = 18) were included. All patients were analysed by two‐dimensional and Doppler echocardiography at rest and during exercise (DST) and underwent cardiopulmonary exercise testing and NT‐proBNP analysis during exercise. HFpEF during exercise was defined as exertional dyspnoea and peak VO2 ≤ 20.0 mL/min/kg. In patients with suspected HFpEF at rest, 84.6% of these patients developed HFpEF during exercise, whereas in the group of asymptomatic patients with hypertension and healthy subjects, the rate of developed HFpEF during exercise was 0%. Regarding the diagnostic performance of DST to detect HFpEF during exercise, an E/e′ ratio >15 during exercise was the most accurate parameter to detect HFpEF (accuracy 86%), albeit a low sensitivity (45.5%). Nonetheless, combining E/e′ with tricuspid regurgitation (TR) velocity > 2.8 m/s during exercise provided a significant increase in the sensitivity to detect patients with HFpEF during exercise (sensitivity 72.7%, specificity 79.5%, and accuracy 78%). Consistent with these findings, an increase of E/e′ was significantly linked to worse peak VO2, and the combination of an increase of both E/e′ and TR velocity was associated with elevated NT‐proBNP values during exercise.ConclusionsThe findings of this pilot study suggest that DST using E/e′ ratio and TR velocity could be of potential usefulness to diagnose HFpEF during exercise in patients with suspected HFpEF at rest.
Early Cretaceous granitic dykes in the western Dabie Orogen, China: Geochronology, petrogenesis, and tectonic implications
Authors: Zhu Jiang , Wang Lianxun , Ma Jian , Zhou Zuomin , Deng Xin , Hu Junliang 
Published: November 2018

Whole‐rock major‐trace elemental, whole‐rock Sr–Nd, and zircon U–Pb–Hf isotopic analyses have been carried out on two suites of Early Cretaceous granitic dykes in the western Dabie Orogen (Central China) with the aim of addressing their petrogenesis and geodynamic significance. LA‐ICPMS zircon U–Pb dating reveals that the E‐W‐trending granitic dykes have emplacement ages of 133.9 ± 1.6 and 132.8 ± 1.0 Ma, while the NW‐trending granitic dykes have emplacement ages of 121.4 ± 0.9 and 120.5 ± 0.7 Ma. These rocks have high concentrations of SiO2 and K2O, belonging to the high‐K calc‐alkaline and shoshonitic series. They are metaluminous to peraluminous and are mainly fractionated I‐type granite. The E‐W‐trending granites have moderate initial 87Sr/86Sr ratios (0.70614 to 0.70878) and negative εNd(t) values varying from −16.2 to −17.2 with two‐stage Nd model ages of 2.20 to 2.43 Ga. They exhibit a narrow range of zircon εHf(t) values (−22.34 to −23.70) with two‐stage Hf model ages of 2.31 to 2.36 Ga. These isotopic signatures suggest a homogeneous crustal source without significant magma contamination or mixing. The NW‐trending granites have initial 87Sr/86Sr ratios ranging from 0.70774 to 0.71034 and negative εNd(t) values varying from −10.9 to −9.5 with two‐stage Nd model ages of 1.69 to 1.80 Ga. They yield variable zircon εHf(t) values of −17.06 to −0.39 with two‐stage Hf model ages of 1.07 to 1.99 Ga, implying heterogeneous crustal signatures with minor mantle materials involved. Combining the geological, geochemical, and isotopic evidences, the E‐W‐trending granitic dykes are considered to be derived from partial melting of crustal materials under normal thickness during a transitional period following the tectonic collapse, while the NW‐trending granitic dykes resulted from crust melting in an extensional setting, most likely induced by the asthenospheric upwelling. Our results support that the western Dabie Orogen could have experienced S‐N‐directed compression (pre. 133 Ma), S‐N‐directed extension (ca. 133 Ma), and general E‐W‐directed extension (ca. 120 Ma). We propose that the Dabie Orogen has experienced tectonic collapse of the thickened lower crust and also has been affected by the subduction of the Izanagi (or Palaeo‐Pacific) Plate during the Early Cretaceous.
Resting‐state functional connectivity after concussion is associated with clinical recovery
Authors: Kaushal Mayank , España Lezlie Y. , Nencka Andrew S. , Wang Yang , Nelson Lindsay D. , McCrea Michael A. , Meier Timothy B. 
Published: November 2018

AbstractThere has been a recent call for longitudinal imaging studies to better characterize the time course of physiological recovery following sport‐related concussion (SRC) and its relationship with clinical recovery. To address this, we evaluated changes to resting‐state functional connectivity (rs‐FC) of the whole‐brain network following SRC and explored associations between rs‐FC and measures of clinical outcome. High school and collegiate football athletes were enrolled during preseason. Athletes that suffered SRC (N = 62) were assessed across the acute (within 48 hr) and sub‐acute (days 8, 15, and 45) phases. Matched football athletes without concussion served as controls (N = 60) and participated in similar visits. Multi‐band resting‐state fMRI was used to assess whole‐brain rs‐FC at each visit using network‐based statistic and average nodal strength from regions of interest defined using a common whole‐brain parcellation. Concussed athletes had elevated symptoms, psychological distress, and oculomotor, balance, and memory deficits at 48 hr postconcussion relative to controls, with diminished yet significant elevations in symptoms and psychological distress at 8 days. Both rs‐FC analyses showed that concussed athletes had a global increase in connectivity at 8 days postconcussion relative to controls, with no differences at the 48‐hr, 15‐day, or 45‐day visits. Further analysis revealed the group effect at the 8‐day visit was driven by the large minority of concussed athletes still symptomatic at their visit; asymptomatic concussed athletes did not differ from controls. Findings from this large‐scale, prospective study suggest whole‐brain rs‐FC alterations following SRC are delayed in onset but associated with the presence of self‐reported symptoms.
Discriminating Alzheimer's disease progression using a new hippocampal marker from T1‐weighted MRI: The local surface roughness
Authors: Platero Carlos , López María Eugenia , Carmen Tobar María del , Yus Miguel , Maestu Fernando 
Published: November 2018

AbstractHippocampal atrophy is one of the main hallmarks of Alzheimer's disease (AD). However, there is still controversy about whether this sign is a robust finding during the early stages of the disease, such as in mild cognitive impairment (MCI) and subjective cognitive decline (SCD). Considering this background, we proposed a new marker for assessing hippocampal atrophy: the local surface roughness (LSR). We tested this marker in a sample of 307 subjects (normal control (NC) = 70, SCD = 87, MCI = 137, AD = 13). In addition, 97 patients with MCI were followed‐up over a 3‐year period and classified as stable MCI (sMCI) (n = 61) or progressive MCI (pMCI) (n = 36). We did not find significant differences using traditional markers, such as normalized hippocampal volumes (NHV), between the NC and SCD groups or between the sMCI and pMCI groups. However, with LSR we found significant differences between the sMCI and pMCI groups and a better ability to discriminate between NC and SCD. The classification accuracy of the LSR for NC and SCD was 68.2%, while NHV had a 57.2% accuracy. In addition, the classification accuracy of the LSR for sMCI and pMCI was 74.3%, and NHV had a 68.3% accuracy. Cox proportional hazards models adjusted for age, sex, and education were used to estimate the relative hazard of progression from MCI to AD based on hippocampal markers and conversion times. The LSR marker showed better prediction of conversion to AD than NHV. These results suggest the relevance of considering the LSR as a new hippocampal marker for the AD continuum.
Predictors of successful manual rotation for occiput posterior positions
Authors: Bertholdt Charline , Gauchotte Emilie , Dap Matthieu , Perdriolle‐Galet Estelle , Morel Olivier 
Published: November 2018

AbstractObjectiveTo identify predictors of the success of manual rotation of fetuses in an occiput posterior position.MethodsA prospective, observational, single‐center study included all women with a singleton pregnancy at term with a fetus in an occiput posterior position for whom manual rotation was attempted from December 1, 2013, to April 30, 2015 at a tertiary care maternity unit in Nancy, France. Occiput posterior position was confirmed by ultrasonography, and success of manual rotation was defined by the occiput anterior position of the fetus after the attempt.ResultsOcciput posterior position was diagnosed in 233 (9.2%) of the 2522 deliveries during the study period and the majority of cases were managed successfully by manual rotation (167 [71.7%]). Factors associated with successful rotation were fetal engagement (adjusted odds ratio [aOR] 2.20, 95% confidence interval [CI] 1.05–4.56), spontaneous labor (aOR 1.85, 95% CI 1.01–3.43), and no failure to progress (aOR 2.01, 95% CI 1.02–3.94). Successful manual rotation was associated with lower rates of cesarean (P<0.001) and instrumental (P<0.001) deliveries.ConclusionStudy findings suggested that manual rotation, especially after fetal engagement, succeeded more often when performed systematically than when it was attempted after failure to progress.
Angiotensin II confers resistance to apoptosis in cardiac myofibroblasts through the AT1/ERK1/2/RSK1 pathway
Authors: Cai Wenfeng , Zhong Shuping , Zheng Fuchun , Zhang Yanmei , Gao Fenfei , Xu Hongquan , Cai Xiangna , Lan Junhong , Huang Danmei , Shi Ganggang 
Published: November 2018

ABSTRACTMyofibroblast apoptosis is essential for normal resolution of wound repair, including cardiac infarction repair. Impaired cardiac myofibroblast (CMF) apoptosis is associated with excessive extracellular matrix (ECM) deposition, which could be responsible for pathological cardiac fibrosis. Conventionally, angiotensin II (Ang II), a soluble peptide, is implicated in fibrogenesis because it induces cardiac fibroblast (CFb) proliferation, differentiation, and collagen synthesis. However, the role of Ang II in regulation of CMF survival and apoptosis has not been fully clarified. In this report, we cultured neonatal rat CFbs, which transform into CMFs after passage 3 (6–8 days), and investigated the effects of Ang II on CMFs challenged by TNF‐α combined with cycloheximide and the underlying mechanisms. Here, we show that Ang II rapidly activates MAPKs but not AKT in CMFs and confers apoptosis resistance, as evidenced by the inhibition of caspase‐3 cleavage, early apoptotic cells and late apoptotic cells. This inhibitory effect of Ang II was reversed by blockade of AT1 or inactivation of ERK1/2 or RSK1 but not AT2, indicating that activation of the prosurvival AT1/ERK1/2/RSK1 signaling pathway mediates apoptosis resistance. TGF‐β, a latent fibrotic factor, was found to have no relation to Ang II‐induced apoptosis resistance in our study. Furthermore, Ang II‐mediated apoptosis resistance, which was conferred by activation of the AT1/ERK1/2/RSK1 signaling pathway, was also confirmed in human adult ventricular cardiac myofibroblasts. Collectively, our findings suggest a novel profibrotic mechanism of Ang II in which it promotes myofibroblast resistance to apoptosis in addition to classical mechanisms, providing a potential novel therapeutic approach by targeting prosurvival signaling pathways. © 2018 IUBMB Life, 71(1):261–276, 2019
Palliation of malignant gastroduodenal obstruction with self‐expandable metal stent using side‐ and forward‐viewing endoscope: Feasibility and outcome
Authors: Kumar Vinay , Ghoshal Uday C , Mohindra Samir , Saraswat Vivek A 
Published: November 2018

BackgroundThe endoscopic placement of a self‐expandable metal stent (SEMS), an alternative to surgical bypass for the palliation of malignant gastric outlet obstruction (GOO), is commonly performed using a forward‐viewing endoscope with a wide therapeutic channel; however, due to limited availability, most Indian centers use a side‐viewing duodenoscope. We studied the feasibility and outcome of SEMS placement using side‐ and forward‐viewing endoscopes.MethodData of patients undergoing SEMS placement using side‐ and forward‐viewing endoscopes with a therapeutic channel for the palliation of malignant GOO presenting during a 5‐year period were analyzed retrospectively. Follow‐up data were obtained from records and telephonic interviews, and technical and clinical success, complications, and survival were evaluated.ResultsOf 114 patients (age 56.5 ± 11.6 years, 59 [52%] female), 90 (79%) and 24 (21%) underwent SEMS placement using side‐ and forward‐viewing endoscopes, respectively. Technical (89, 98.9% vs. 24, 100%, P = ns) and clinical success (84, 93.3% vs. 23, 95.8%, P = ns) and complication rate (3, 3.3% vs. 0, P = ns) between side‐ and forward‐viewing endoscopes were comparable. However, SEMS could be placed in a shorter time using a forward‐ rather than side‐viewing endoscope (21 min [inter‐quartile range 19.5–35] vs. 34 min [25–45], P = < 0.001). SEMS could be deployed successfully with a forward‐viewing endoscope in two patients in whom an initial attempt using side‐viewing endoscope failed. Gastric outlet obstruction scoring system (GOOSS) improved following stent placement (median 0, range 0–2 vs. 2, 0–3, P = 0.0001). The survival of patients undergoing SEMS placement using side‐ and forward‐viewing endoscopes was comparable.ConclusionAlthough side‐ and forward‐viewing endoscopes are equally effective for antroduodenal SEMS placement, the procedure can be performed faster using the latter.
Characterization and oxidative stability of oils and bioactive compounds of the fruits ofByrsonima cydoniifoliaA. Juss. at different ripening stages
Authors: Marcelino Gabriela , Donadon Juliana R , Caires Anderson RL , Michels Flavio S , Oliveira Lincoln CS , Cortes Mário R , Maldonade Iriani R , Cavalheiro Leandro F , Nazário Carlos ED , Maróstica Júnior Mário R , Santos Nathalia MD , Batista Patrícia B , Pott Arnildo , Nunes Ângela A , Figueiredo Priscila S , Hiane Priscila A , Nascimento Valter A , Guimarães Rita CA 
Published: November 2018

AbstractBACKGROUNDFruits present high concentrations of bioactive compounds that are beneficial to health due to their antioxidant properties. New alternatives to vegetable oils with such properties have been studied. We determined the chemical compounds ofByrsonima cydoniifoliaA. Juss. fruits in three ripening stages as well as the optical behavior and quality level of the oils.RESULTSThe ripening stage affected the chemical composition of the fruits and oils. The fruits presented high values of bioactive compounds, as ascorbic acid (1.46–1.82 g kg−1) and total phenols (3.54–15.91 g gallic acid equivalents kg−1), as well as showed excellent antioxidant activity. The ripe fruits showed high content of carotenoids (45.90 mg kg−1) were lutein is the major carotenoid, representing 55.56%. The oil of the ripe fruits showed high lipid content (252.6 g kg−1) and contained oleic (521.83 g kg−1), palmitic (209.13 g kg−1) and linoleic (195.4 g kg−1) fatty acids. The oil of ripe fruits showed the best oxidative stability, with longer induction period (22.29 h) than the other oils.CONCLUSIONFruits ofB. cydoniifoliaA. Juss. demonstrate to possess a promising potential for the use as functional ingredients. The oil of the ripe fruits was more stable and presents a greater potential to be used for edible purposes. © 2018 Society of Chemical Industry
Vision‐tangible interactive display method for mixed and virtual reality: Toward the human‐centered editable reality
Authors: Zhang Zhenliang , Li Yue , Guo Jie , Weng Dongdong , Liu Yue , Wang Yongtian 
Published: November 2018

AbstractBuilding a human‐centered editable world can be fully realized in a virtual environment. Both mixed reality (MR) and virtual reality (VR) are feasible solutions to support the attribute of edition. Based on the current development of MR and VR, we present the vision‐tangible interactive display method and its implementation in both MR and VR. We address the issue of MR and VR together because they are similar regarding the proposed method. The editable mixed and virtual reality system is useful for studies, which exploit it as a platform. In this paper, we construct a virtual reality environment based on the Oculus Rift, and an MR system based on a binocular optical see‐through head‐mounted display. In the MR system about manipulating the Rubik's cube, and the VR system about deforming the virtual objects, the proposed vision‐tangible interactive display method is utilized to provide users with a more immersive environment. Experimental results indicate that the vision‐tangible interactive display method can improve the user experience and can be a promising way to make the virtual environment better.
Can Pharyngeal Packing Prevent Postoperative Nausea and Vomiting in Nasal Surgery?
Authors: Jin Ho Joon , Kim Subin , Hwang Se Hwan 
Published: November 2018

ObjectivesWe aimed to perform a meta‐analysis for the efficacy of pharyngeal packing during nasal surgery in the prevention of postoperative nausea and vomiting (PONV).Data SourcesMEDLINE, SCOPUS, and the Cochrane database.MethodsTwo authors independently searched the databases for relevant studies from inception to October 2017. Included studies were randomized controlled studies published in English comparing pharyngeal packing during intubation (packing group) with no packing (control group) in patients who underwent nasal surgery. Outcomes of interest included the incidence of PONV and throat pain during the first 24 hours postsurgery.ResultsTen studies were included in the meta‐analysis. The incidence of moderate‐to‐severe PONV in the recovery room was significantly higher in the packing group than in the control group. However, the incidence of moderate‐to‐severe PONV significantly decreased and was lower in the packing group than in the control group at 2 hours postoperative. The incidence of throat pain was higher in the packing group than in the control group until 2 hours postoperative.ConclusionsConsidering the occurrence of postoperative morbidity according to the time course, pharyngeal packing during nasal surgery does not alleviate PONV but instead could aggravate postoperative throat pain. Additionally, pharyngeal packing has the possibility of airway problem such as the foreign body aspiration. Based on our results, we suggest that there is no need to place a pharyngeal pack to prevent PONV in patients undergoing nasal surgery.Level of Evidence1b Laryngoscope, 129:291–298, 2019