bluuebunny/crossref_metadata_2025_split huggingface dataset:
Maxillary Pneumosinus Dilatans Presenting With Proptosis: A Case Report and Review of the Literature
Authors: Alatar Abdullah A , AlSuliman Yazeed A , Alrajhi Maha S , Alfawwaz Fahad S 
Published: February 2019

Background: Pneumosinus dilatans (PSD) is a rare pathological paranasal sinus expansion. This condition is usually symptomatic or cosmetically apparent, requiring surgical intervention. Multiple hypotheses have been postulated as to the cause of this condition; however, the precise cause and pathogenesis remain obscure. Case report and Methods: An 11-year-old boy presented with right eye bulging and was subsequently found to have PSD of the maxillary sinus. A search was conducted of the PubMed electronic database, using the keywords “pneumosinus dilatans,” “pneum(oco)ele,” “pneum(oc)ele,” “pneum(atoco)ele,” and “air cyst.” Articles published in English were reviewed. Results: The literature review identified 29 cases of PSD involving the maxillary sinus. The mean age of presentation was 25 years old. Only the right maxillary sinus was affected in 16 cases, followed by the bilateral sinuses in 7 cases and the left sinus in 6 cases. In 5 cases, all paranasal sinuses, along with the maxillary sinus, were expanded. The most common presenting symptom was facial swelling, which was found in 55% of the cases, followed by proptosis and pain. Computed tomography is the gold standard radiological method for diagnosing PSD. Conclusions: Pneumosinus dilatans is a rare condition that is usually symptomatic and requires surgical intervention. The etiology of the disease is attributed to multiple hypotheses, but more studies are needed to explore this condition further.
Initial experience with the novel EmboTrap II clot-retrieving device for the treatment of ischaemic stroke
Authors: Valente Iacopo , Nappini Sergio , Renieri Leonardo , Pedicelli Alessandro , Lozupone Emilio , Colosimo Cesare , Mangiafico Salvatore , Limbucci Nicola 
Published: February 2019

Introduction We report our experience with the novel stent-type clot-retrieval device EmboTrap II for the revascularization of large artery occlusions in acute ischaemic stroke. Materials and methods Twenty-nine patients with acute ischaemic stroke due to large artery occlusion underwent mechanical thrombectomy with the new EmboTrap II in two Italian centres. Clinical, procedural and radiological data were collected. Angiographic results and neurological outcomes were analysed. Results Only large vessel occlusions were included. Intravenous thrombolysis was administered in 72% of patients. Successful reperfusion (TICI 2b-3) was obtained in 76% of patients treated exclusively with EmboTrap II. No device-related permanent complications occurred. Conclusion In our experience, mechanical thrombectomy with EmboTrap II is safe and effective. Reperfusion rate was comparable to that obtained with other stent retrievers.
Transvenous Approach for the Treatment of cerebral Arteriovenous Malformations (TATAM): Study protocol of a randomised controlled trial
Authors: Fahed Robert , Darsaut Tim E , Mounayer Charbel , Chapot René , Piotin Michel , Blanc Raphaël , Mendes Pereira Vitor , Abud Daniel G , Iancu Dana , Weill Alain , Roy Daniel , Nico Lorena , Nolet Suzanne , Gevry Guylaine , Raymond Jean 
Published: February 2019

Background Transvenous embolisation is a promising technique but the benefits remain uncertain. We hypothesised that transvenous embolisation leads to a higher rate of arteriovenous malformation angiographic occlusion than transarterial embolisation. Methods The Transvenous Approach for the Treatment of cerebral Arteriovenous Malformations (TATAM) is an investigator initiated, multicentre, prospective, phase 2, randomised controlled clinical trial. To test the hypothesis that transvenous embolisation is superior to transarterial embolisation for arteriovenous malformation obliteration, 76 patients with arteriovenous malformations considered curable by up to two sessions of endovascular therapy will be randomly allocated 1:1 to treatment with either transvenous embolisation (with or without transarterial embolisation) (experimental arm) or transarterial embolisation alone (control arm). The primary endpoint of the trial is complete arteriovenous malformation occlusion, assessed by catheter cerebral angiography. Complete occlusions will be confirmed at 3 months, while incompletely occluded arteriovenous malformations, considered treatment failures, will then be eligible for complementary treatments by surgery, radiation therapy, or even transvenous embolisation. Standard procedural safety outcomes will also be assessed. Patient selection will be validated by a case selection committee, and participating centres with limited experience in transvenous embolisation will be proctored. Discussion The TATAM trial is a transparent research framework designed to offer a promising but still unvalidated treatment to selected arteriovenous malformation patients. Clinical Trial Registration-URL: http://www.clinicaltrials.gov . Unique identifier: NCT03691870.
Frailty Questionnaire Is Not a Strong Prognostic Factor for Functional Outcomes in Hip or Knee Arthroplasty Patients
Authors: Meessen Jennifer M. T. A. , Fiocco Marta , Leichtenberg Claudia S. , Vliet Vlieland Thea P. M. , Slagboom P. Eline , Nelissen Rob G. H. H. 
Published: February 2019

Introduction: Up to 33% and 25% of patients with end-stage hip and knee osteoarthritis (OA) are considered frail by the Groningen Frailty Indicator (GFI). This study aims to assess whether frail patients have lower functional gains after arthroplasty and to assess GFI as a tool to discriminate between good and adverse change score. Materials and Methods: Patients with end-stage hip/knee OA scheduled for arthroplasty were recruited from the Longitudinal Leiden Orthopaedics Outcomes of Osteo-Arthritis Study. Functional outcome was measured as change score on the Hip Osteoarthritis Outcome Score/Knee Osteoarthritis Outcome Score (HOOS/KOOS), by subtracting preoperative score from 1-year postsurgery score and then dichotomized based on a cutoff of 20 points. For each HOOS/KOOS subscale, 3 models were estimated: GFI univariate (model 1), GFI and baseline score (model 2), and baseline score univariate (model 3). A receiver operating characteristic analysis was performed to assess the discriminative ability of each model. Results: Eight hundred five patients with end-stage hip OA (31.4% frail) and 640 patients with end-stage knee OA (25.4% frail) were included. Frail patients were older, had a higher body mass index, had more comorbidities, and lived more often alone. Persons considered frail by GFI had significant lower baseline score; however, except for “function in sports and recreation” and “quality of life,” change scores were similar in frail and nonfrail persons. The discriminatory value of GFI was negligible for all HOOS/KOOS subscales. Baseline score, however, was adequate to discriminate between total knee arthroplasty patients with more or less than twice the minimally clinically important difference on KOOS symptoms subscale (area under the curve = 0.802). Discussion/Conclusion: Although frail patients with OA have lower functioning scores at baseline, the change scores on HOOS/KOOS subscales are similar for both frail and nonfrail patients. Exploring other heath assessements may improve patient-specific outcome prediction.
Malglycemia is associated with poor outcomes in pediatric and adolescent hematopoietic stem cell transplant patients
Authors: Sopfe Jenna , Pyle Laura , Keating Amy K. , Campbell Kristen , Liu Arthur K. , Wadwa R. Paul , Verneris Michael R. , Giller Roger H. , Forlenza Gregory P. 
Published: February 2019

Abstract
Malglycemia (hypoglycemia, hyperglycemia, and/or glycemic variability) in adult hematopoietic stem cell transplant (HSCT) recipients is associated with increased infection, graft-versus-host disease, organ dysfunction, delayed engraftment, and mortality. Malglycemia has not been studied in pediatric HSCT recipients. This study aimed to characterize the incidence and consequences of malglycemia in this population. Medical records for a cohort of 344 patients, age 0 to 30 years, who underwent first HSCT from 2007 to 2016 at Children’s Hospital Colorado were retrospectively reviewed. Glucose data were analyzed in intervals and assessed for potential risk factors and associated outcomes. Malglycemia occurred in 43.9% of patients. Patients with a day 0 to 100 mean glucose of 100 to 124 mg/dL had a 1.76-fold (95% confidence interval [CI], 1.10-2.82; P = .02) increased risk of death and patients with a day 0 to 100 mean glucose ≥ 125 mg/dL had a 7.06-fold (95% CI, 3.84-12.99; P &lt; .0001) increased risk of death compared with patients with a day 0 to 100 mean glucose &lt; 100 mg/dL. For each 10 mg/dL increase in pre-HSCT glucose, there was a 1.11-fold (95% CI, 1.04-1.18; P = .0013) increased risk of post-HSCT infection. These adverse impacts of malglycemia occurred independent of transplant type, graft-versus-host disease, and steroid therapy. Malglycemia in the pediatric HSCT population is independently associated with significantly increased risk of morbidity and mortality. Further research is required to evaluate the utility of glucose control to mitigate these relationships and improve HSCT outcomes. This trial was registered at www.clinicaltrials.gov as #NCT03482154.
Identifying Cancer-Directed Surgeries in Medicare Claims: A Validation Study Using SEER-Medicare Data
Authors: Lavery Jessica A. , Lipitz-Snyderman Allison , Li Diane G. , Bach Peter B. , Panageas Katherine S. 
Published: February 2019

Purpose Medicare claims provide a rich data source for large-scale quality assessment because data are available for all beneficiaries nationally. For cancer surgery, the absence of information regarding site of cancer and date of diagnosis on an administrative claim necessitates testing to ensure accurate quality assessment and public reporting. Methods Using the SEER Medicare–linked database as the gold standard, we developed and tested an approach to identify cancer-directed surgeries from Medicare fee-for-service claims alone. Our analysis evaluated two questions: (1) Can we identify a large percentage of patients who underwent a cancer-directed surgery using only Medicare claims? (2) Of all patients identified as having undergone a cancer-directed surgery, what percentage had cancer? We evaluated this approach for 17 primary cancer sites. Results The number of Medicare beneficiaries diagnosed with their first cancer during the years 2011 to 2013 and who underwent cancer-directed surgery ranged from 45 patients (bones and joints) to 20,163 patients (breast). The percentage of cancer-directed surgeries identified using Medicare claims alone ranged from 62% (skin melanoma) to 94% (prostate). For all but three cancer sites (skin melanoma, thyroid, and urinary bladder), more than 80% of cancer-directed surgeries were identified using our approach. Of all surgeries identified, more than 90% were for patients with cancer. Conclusion Identifying patients who underwent a cancer-directed surgery from Medicare claims is feasible for many cancer sites, although careful consideration needs to be given to the validity of each site. Our findings support the use of Medicare claims for large-scale quality assessment of cancer surgery by disease site.
Neoplasm Risk Among Individuals With a Pathogenic Germline Variant in DICER1
Authors: Stewart Douglas R. , Best Ana F. , Williams Gretchen M. , Harney Laura A. , Carr Ann G. , Harris Anne K. , Kratz Christian P. , Dehner Louis P. , Messinger Yoav H. , Rosenberg Philip S. , Hill D. Ashley , Schultz Kris Ann P. 
Published: February 2019

Purpose DICER1 syndrome is an autosomal-dominant, pleiotropic tumor-predisposition disorder caused by pathogenic germline variants in DICER1. We sought to quantify risk, hazard rates, and the probability of neoplasm incidence accounting for competing risks (“cumulative incidence”) of neoplasms (benign and malignant) and standardized incidence ratios for malignant tumors in individuals with DICER1 pathogenic variation. Patients and Methods We combined data from three large cohorts of patients who carry germline pathogenic variation in DICER1. To reduce ascertainment bias, we distinguished probands from nonprobands. Neoplasm diagnoses were confirmed by review of pathology reports and/or central review of surgical pathology materials. Standardized cancer incidence ratios were determined relative to the SEER program, which does not capture all DICER1-associated neoplasms. For all malignancies and benign tumors (“neoplasms,” excluding type Ir pleuropulmonary blastoma and thyroid nodules), we used the Kaplan-Meier method and nonparametric cumulative incidence curves to estimate neoplasm-free survival. Results We calculated the age at first neoplasm diagnosis (systematically ascertained cancers plus DICER1-associated neoplasms pleuropulmonary blastoma, cystic nephroma, and nasal chondromesenchymal hamartoma) in 102 female and male nonproband DICER1 carriers. By age 10 years, 5.3% (95% CI, 0.6% to 9.7%) of nonproband DICER1 carriers had developed a neoplasm (females, 4.0%; males, 6.6%). By age 50 years, 19.3% (95% CI, 8.4% to 29.0%) of nonprobands had developed a neoplasm (females, 26.5%; males, 10.2%). After age 10 years, female risk was elevated compared with male risk. Standardized cancer incidence ratio analysis of 102 nonproband DICER1 carriers, which represented 3,344 person-years of observation, showed significant cancer excesses overall, particularly of gynecologic and thyroid cancers. Conclusion This work provides the first quantitative analysis of site-specific neoplasm risk and excess malignancy risk in 102 systematically characterized nonproband DICER1 carriers. Our findings inform DICER1 syndrome phenotype, natural history, and genetic counseling.
Preparedness components of health systems in the Eastern Mediterranean Region for effective responses to dust and sand storms: a systematic review
Authors: Allahbakhshi Kiyoumars , Khorasani-Zavareh Davoud , Khani Jazani Reza , Ghomian Zohreh 
Published: February 2019

Background:Dust and Sand Storm (DSS), according to estimates by global reports, will increase dramatically in the Eastern Mediterranean Region (EMR). Numerous health problems caused by DSS will be severely affected regions and vulnerable groups. This study aimed to identify the components of the preparedness of health systems for the DSS phenomenon in EMR.Methods:In this systematic review, the peer-reviewed papers in four electronic databases, including Medline through PubMed, Scopus, ISI Web of Science and the Cochrane library, as well as available grey literature, were searched and selected. The research process was carried out by including papers whose results were related to the potential health effects caused by desert dusts in EMR. Was used the combination of three groups of keywords: the exposure factor, health effects as outcomes, and the countries located in EMR. The focus was on the PRISMA checklist, with no time limitations until December 2017. Finally, through 520 related citations, 30 articles were included. Descriptive and thematic content analyses were evaluated.Results:The preparedness components were divided into three and ten main categories and subcategories, respectively. The three categories covered the areas of DSS hazard identification, planning and policy-making, and risk assessment.Conclusions:Recognition of the health system preparedness factors for DSS in EMR will help policy-makers and managers perform appropriate measures when dealing with this hazard. More studies should be conducted to understand these factors in other parts of the world.Registration:PROSPERO registration numberCRD42018093325.
РОЛЬ СОВРЕМЕННЫХ ИННОВАЦИОННЫХ ТЕХНОЛОГИЙ В ОБРАЗОВАТЕЛЬНОМ ПРОЦЕССЕ
Authors: Pavlova Irina Aleksandrovna , Tarasova Elena Vladimirovna 
Published: February 2019

В последние годы в связи с реформами образования в нашей стране происходит поиск современных эффективных методик получения образования и воспитания. Новые потребности развивающегося российского общества невозможно обеспечить без существенной перестройки методик и технологий подготовки кадров высшей квалификации, реализуемых в соответствии с требованиями государственных стандартов. При этом в целях обеспечения соответствующего уровня подготовки обучающихся, и формирования специалиста с высшим образованием, обладающим всеми необходимыми компетенциями, требуется введение новых технологий обучения в процесс образования.Учитывая рост конкуренции на рынке образовательных услуг, подготовка специалистов не может ограничивать себя лишь традиционными лекциями, семинарами, практическими и лабораторными работами. Безусловно, традиционная методика обучения остается незаменимой в случае передачи теоретических знаний и концепций. Но формирование глубоких профессиональных навыков и умений требует иных подходов.Повышению качества подготовки специалистов поможет внедрение инновационных методов обучения. Современные методики обучения акцентируютсвое внимание на раскрытии творческого потенциала студентов, повышению их самостоятельности в изучении материала.В настоящее время процесс осуществления образования во многом связан с применением онлайн-обучения. Значительный информационный поток в сети Интернет и возможности технологий дистанционного обучения должны благоприятно сказываться на формировании итоговых навыков и умений. Только грамотно организованный процесс электронного обучения приведет к формированию квалифицированного специалиста. В данной статье рассматриваются вопросы актуальности, возможности и необходимости применения современных форм обучения в образовательном процессе.Цель – изучение вопросов, связанных с возможностью внедрения новых технологий и их активное использование в образовательном процессе.Метод или методология проведения работы: теоретические методы (анализ и синтез, сравнение, классификация, обобщение); методы эмпирического уровня (изучение литературы, документов и результатов деятельности, оценивание методики).Результаты: выявление ряда проблем, возникающих при внедрении активных форм обучения в образовательный процесс.Область применения результатов: результаты проведенного исследования могут быть учтены при организации образовательного процесса, с использованием активных форм обучения, как в учреждениях высшего образования, так и средне-специального.
Consumer Search and Retail Market Structure
Authors: Rhodes Andrew , Zhou Jidong 
Published: February 2019

A puzzling feature of many retail markets is the coexistence of large multiproduct firms and smaller firms with narrow product ranges. This paper provides a possible explanation for this puzzle, by studying how consumer search frictions influence the structure of retail markets. In our model, single-product firms that supply different products can merge to form a multiproduct firm. Consumers wish to buy multiple products and, due to search frictions, value the one-stop shopping convenience associated with a multiproduct firm. We find that, when search frictions are relatively large, all firms are multiproduct in equilibrium. However, when search frictions are smaller, the equilibrium market structure is asymmetric, with different retail formats coexisting. This allows firms to better segment the market and, as such, typically leads to the weakest price competition. When search frictions are low, this asymmetric market structure is also the worst for consumers. Moreover, due to the endogeneity of market structure, a reduction in the search friction can increase market prices and harm consumers. The online appendix is available at https://doi.org/10.1287/mnsc.2018.3058 . This paper was accepted by Eric Anderson, marketing.
Sintesis dan Karakterisasi CNT (Carbon Nanotube) Berdopan Logam Kobalt
Authors: Lestari Nur Dwi , Pardoyo Pardoyo , Subagio Agus 
Published: February 2019

Telah dilakukan penelitian sintesis dan karakterisasi CNT (Carbon Nanotube) dengan doping logam kobalt. Penelitian ini bertujuan untuk menentukan karakter CNT sebelum dan setelah didoping dengan variasi konsentrasi logam 10%, 20%, 30%, 40% dan 50%. Metode yang digunakan pada penelitian ini adalah impregnasi basah yang meliputi perendaman pada larutan logam dan kalsinasi. Hasil impregnasi dianalisis menggunakan Fourier Transform-Infra Red (FT-IR), GSA (Gas Sorption Analysis), Scanning Electron Microscopy (SEM) dan Energy Dispersive X-Ray Spectroscopy (EDS). Analisis FT-IR menunjukkan adanya vibrasi ulur dari ikatan Co-C dan Co-O. Hasil GSA menunjukkan bahwa CNT loading 30% mempunyai luas permukaan tertinggi yaitu 69,192 m2/g. Hasil SEM-EDS menunjukkan bahwa morfologi permukaan dinding CNT ditutupi aggregat-aggregat kobalt. Pada hasil EDS fraksi kobalt dihasilkan adalah 1,96 % yang nilainya tidak jauh berbeda dari fraksi Fe yaitu 1,49%. Hal ini menunjukkan bahwa CNT doping logam Co menggunakan metode impregnasi basah tidak efektif.
Patatin-like phospholipase domain containing 3-gene (adiponutrin), preptin, kisspeptin and amylin regulates oocyte developmental capacity in PCOS
Authors: Celik Nilufer , Aydin Suleyman , Ugur Kader , Yardim Meltem , Acet Mustafa , Yavuzkir Seyda , Sahin ć°brahim , Celik Onder 
Published: February 2019

This study was planned to test whether follicular fluid (FF) levels of patatin-like phospholipase domain containing 3-gene (PNPLA3:adiponutrin), preptin, kisspeptin, and amylin change in polycystic ovarian syndrome (PCOS). A total of 40 infertile volunteers undergoing IVF/ICSI were included in the study. They were divided into two groups as PCOS (n=20) and control group without PCOS (n=20). The controls were recruited from subjects with a poor ovarian response. The PCOS and control participants were matched according to their body mass index (BMI). Each group of participants underwent ovarian stimulation with GnRH antagonist protocol. Blood and FF samples of one dominant follicle were obtained from each subject during the oocyte pick-up. FF and serum levels of PNPLA3, preptin, kisspeptin and amylin were measured through ELISA. Amylin and adiponutrin median values were not different according to study groups (p>0.05). FF-preptin median values in the control group were similar to the serum preptin values of control and PCOS groups (Z=0.970, p=1.000 and Z=2.631, p=0.051, respectively). Medians of the serum preptin in control and PCOS groups were the same (Z=1.649; p=0.595). FF-preptin median values of PCOS group were significantly lower than the preptin median values of the control group. Serum preptin levels were positively correlated with HOMA-IR, but not with pregnancy rates and the number of retrieved oocytes. Serum kisspeptin levels were negatively correlated with the number of retrieved oocytes and pregnancy rates. While amylin and adiponutrin have no role in the folliculogenesis, kisspeptin and preptin work together for regulating follicle developmental capacity in PCOS.
Integrating Strength and Power Development in the Long-Term Athletic Development of Young Rugby Union Players: Methodological and Practical Applications
Authors: Durguerian Alexandre , Piscione Julien , Mathieu Bertrand , Lacome Mathieu 
Published: February 2019

ABSTRACTTHE PURPOSE OF THIS ARTICLE IS TO DESCRIBE THE TRAINING STRATEGY BUILT BY THE FRENCH RUGBY UNION TO OPTIMIZE STRENGTH AND POWER DEVELOPMENT IN ELITE RUGBY UNION PLAYERS. THE TRAINING PROCESS IS BASED ON 4 STAGES COMPOSED OF EDUCATIONAL AND TECHNICAL EFFICIENCY, WORK CAPACITY, MAXIMAL STRENGTH, AND EXPLOSIVE POWER. THE EVOLUTION OF THE PLAYER DURING THESE DIFFERENT STEPS SHOULD BE ADJUSTED ACCORDING TO INDIVIDUAL PROGRESSION AND NOT ONLY THEIR CHRONOLOGICAL AND BIOLOGICAL AGE. SUPERVISED TRAINING SESSIONS WITH QUALIFIED AND EXPERIENCED STRENGTH AND CONDITIONING COACHES ARE PARAMOUNT TO ENSURE INDIVIDUALIZED TRAINING AND PROVIDE SOUND PEDAGOGICAL APPROACHES.