bluuebunny/crossref_metadata_2025_split huggingface dataset:
Healing Materialities: framing Biodesign’s potential for conventional and regenerative sustainability
Authors: Pollini Barbara , Rognoli Valentina 
Published: November 2024

Abstract
The rediscovered potential of ‘growing’ instead of ‘making’ drives the emergence of new materialities. This is leading to innovative developments in biotechnologies and Biodesign, both of which are intricately connected and seen as transformative elements in the discourse on sustainability. Biofabricated materials are starting to be evaluated using established sustainability metrics such as life cycle assessment, highlighting their essential role in the circular economy and shedding light on some overlooked process-dependent environmental burdens. At the same time, some biodesigned materials and artefacts are characterised by their ability to transcend the conventional concept of sustainability, embracing the principles of Regenerative Design thanks to the restorative and regenerative potential of living and bioreceptive materials. The study explores the main Biodesign variables, presenting a taxonomy created to comprehensively understand the phenomenon. The resulting findings highlighted the dual nature of Biodesign, which promotes both inner and outer sustainability. These findings gave rise to a conceptual framework defined as ‘Healing Materialities’, developed by the authors to highlight the main Biodesign variables discussed while addressing a broad spectrum of ecological potentials, from conventional to regenerative sustainability. The article discusses the concept of ‘Healing Materialities’, emphasising the role of Biodesign in supporting a profound ecological turn and advocating the adoption of regenerative materials and processes capable of harmonising the long-term needs of both human and non-human entities.
FROBENIUS NUMBERS ASSOCIATED WITH DIOPHANTINE TRIPLES OF $x^2+y^2=z^3$
Authors: KOMATSU TAKAO , GUPTA NEHA , UPRETI MANOJ 
Published: November 2024

AbstractWe give an explicit formula for the Frobenius number of triples associated with the Diophantine equation$x^2+y^2=z^3$, that is, the largest positive integer that can only be represented inpways by combining the three integers of the solutions of$x^2+y^2=z^3$. For the equation$x^2+y^2=z^2$, the Frobenius number has already been given. Our approach can be extended to the general equation$x^2+y^2=z^r$for$r>3$.
Annual bluegrass cross resistance to prodiamine and pronamide in the southern United States
Authors: Osburn Andrew W. , Bowling Rebecca G. , Unruh J. Bryan , McKeithen Chase , Hathcoat Daniel , Bagavathiannan Muthukumar 
Published: November 2024

Abstract
Annual bluegrass is one of the most problematic weeds in the turfgrass industry, exhibiting both cross-resistance and multiple-herbicide resistance. Prodiamine, pronamide, and indaziflam are commonly used preemergence herbicides for the control of this species on golf courses in the southern United States. There have been increasing anecdotal reports of annual bluegrass populations escaping control with these herbicides, but resistance has yet to be confirmed. To evaluate the response of annual bluegrass to three herbicides, populations were collected from golf courses, athletic fields, and landscape areas in Texas and Florida, and a dose-response assay was conducted on populations that were suspected to be resistant to and known to be susceptible to prodiamine, pronamide, and indaziflam. The suspected-resistant populations showed survival to prodiamine at 32 times the recommended field rate (both populations from Florida and Texas) of 736 g ai ha−1, and to pronamide at 32 times (the Florida populations) or 16 times (the Texas populations) the recommended field rate of 1,156 g ha−1. In contrast, the known susceptible populations attained 100% mortality at rates as low as 46 and 578 g ha−1, respectively, from applications of prodiamine and pronamide. For indaziflam, the suspected-resistant populations showed reduced sensitivity up to the recommended field rate of 55 g ha−1, but they were controlled when treated with a rate twice that of the field rate. Overall, annual bluegrass populations with resistance to prodiamine and pronamide, and reduced sensitivity to indaziflam (at the recommended field rate) were confirmed from golf courses in Florida and Texas. In the presence of herbicide-resistant annual bluegrass populations, especially to commonly used herbicides such as prodiamine and pronamide, turfgrass managers should adopt integrated management strategies and frequently rotate herbicide sites of action, rather than relying solely on microtubule-assembly inhibitors or cellulose biosynthesis inhibitors, to control this species.
Discerning TGF and Leader Current Pulse in ASIM Observation
Authors: Mezentsev A. , Østgaard N. , Marisaldi M. , Sarria D. , Lehtinen N. , Neubert T. , Chanrion O. , Gordillo‐Vazquez F. 
Published: November 2024

AbstractTerrestrial gamma ray flash (TGF) observations made by the Atmosphere‐Space Interaction Monitor (ASIM) have demonstrated that these TGFs are accompanied by a prominent optical pulse from a hot leader channel. It is hard to confidently resolve the true sequence of the events in the source region due to temporal proximity of the involved processes. Here we report a bright long duration TGF together with its associated optical recordings showing clear temporal separation between the TGF and the optical pulse. In this observation the optical pulse is clearly distinct and subsequent relative to the TGF. The corresponding lightning discharge occurred at the very end of the TGF. We conclude that the current surge inside the lightning leader channel cannot be responsible for generation of this TGF. The current surge that produced the associated optical pulse can itself be conditioned by the TGF and may be responsible for the TGF termination.
Drivers of Seasonal and Diel Methane Emissions From a Seagrass Ecosystem
Authors: Henriksson Linnea , Yau Yvonne Y. Y. , Majtényi‐Hill Claudia , Ljungberg Wilma , Tomer Aprajita S. , Zhao Shibin , Wang Fenfang , Cabral Alex , Asplund Maria , Santos Isaac R. 
Published: November 2024

AbstractSeagrass meadows are effective sinks of atmospheric carbon dioxide (CO2). However, there is little insight on how methane (CH4) emissions may potentially offset carbon sequestration in seagrass meadows. Here, we resolve diel and seasonal dynamics of CH4 and CO2 water‐air fluxes over a cold‐temperate Zostera marina seagrass meadow using high‐resolution timeseries observations in seawater. CH4 was emitted from the seagrass‐dominated coastal bay year‐round to atmosphere with CH4 fluxes ranging from 0.2 to 2.6 μmol m−2 d−1. These fluxes are at the lower end of earlier estimates based mostly on short‐term (i.e., 1 day) observations. The 13‐fold seasonal fluctuations in CH4 emissions were greater than the 6‐fold diel fluctuation. Radon observations imply that dissolved CH4 was primarily originated from sediment porewater. The main fate of CH4 in the water was outgassing to the atmosphere via wind forcing. Oxygen and temperature partially controlled dissolved CH4 seasonal dynamics. There was an annual average uptake of CO2 from the atmosphere (−0.9 ± 1.5 mmol m−2 d−1) driven by enhanced photosynthesis in the spring and summer. The CO2‐equivalent CH4 outgassing (0.5 ± 0.6 g CO2 eq m−2 yr−1) offsets only 0.8% of the sediment carbon accumulation in this cold‐temperate Z. marina meadows over a 20‐year time horizon. The CO2‐equivalent CH4 flux was 6% of the average annual CO2 uptake. Hence, CH4 emissions from this cold‐temperate seagrass meadow acted as a minor offset to carbon sequestration.
The Mother's Day Geomagnetic Storm on 10 May 2024: Aurora Observations and Low Latitude Space Weather Effects in Mexico
Authors: Gonzalez‐Esparza J. A. , Sanchez‐Garcia E. , Sergeeva M. , Corona‐Romero P. , Gonzalez‐Mendez L. X. , Valdes‐Galicia J. F. , Aguilar‐Rodriguez E. , Rodriguez‐Martinez M. , Ramirez‐Pacheco C. , Castellanos C. I. , Pazos M. , Mendoza B. , Gatica‐Acevedo V. J. , Melgarejo‐Morales A. , Caraballo R. , Andrade‐Mascote E. , Villanueva‐Hernandez P. , Bonifaz‐Alfonzo R. , Sierra P. , Romero‐Hernandez E. , Peralta‐Mendoza I. , Perez‐Tijerina E. , Mejia‐Ambriz J. C. , Guerrero‐Peña C. , Caccavari A. , Cifuentes‐Nava G. , Hernandez‐Quintero E. 
Published: November 2024

AbstractOn 10 May 2024, a severe geomagnetic storm coinciding with Mother's Day in Mexico lasted over 40 hr and produced polar auroras observable at low latitudes. This storm, the most intense since 2003, resulted from a series of solar flares and coronal mass ejections from active region 3664. The event was significant for space weather studies in Mexico, marking a milestone by enabling comprehensive measurements of its effects. The Mexico Space Weather Service (SCIESMEX) and the National Space Weather Laboratory (LANCE) had prepared for such an event since their inception. LANCE's instrument networks recorded solar chromospheric images, solar radio bursts, geomagnetic variations, Schumann resonances, ionospheric disturbances, and energetic particle flows. They also monitored Geomagnetically Induced Currents (GICs) in three strategic substations of the national electrical system. This provided unprecedented insights into the dynamics of severe space weather events at the North‐American low‐latitude environment. Citizen science efforts documented auroras and regional responses, capturing variations in geomagnetic indices, ionospheric disturbances, cosmic ray fluxes, GICs, and technological impacts. SCIESMEX worked with the National Civil Protection System (SINAPROC) to issue warnings, ensuring public awareness and preparedness. This coordination underscores the importance of effective communication and collaboration in mitigating impacts. The May 2024 geomagnetic storm demonstrated the critical role of preparedness, research, and public education in reducing the effects of future space weather events in Mexico.
Dosing of antidepressants in relation to body weight in children and adolescents with overweight
Authors: Izsak Julia , Kimland Elin E. , Martikainen Jari , Dahlén Elin , Kindblom Jenny M. 
Published: November 2024

AbstractOverweight and obesity in children and adolescents may impact pharmacokinetics and drug exposure. The aim of the present study was to evaluate doses of antidepressants in relation to body weight in children. We used data from the BMI Epidemiology Study (BEST) Gothenburg cohort and the National Prescribed Drug Register and included children and adolescents with a prescription of fluoxetine (n = 347) or sertraline (n = 733) and a weight measurement. For fluoxetine, individuals with overweight or obesity received slightly lower doses at first prescriptions, but not in iterated prescriptions. The weight-normalized dose was lower in individuals with overweight or obesity in first and iterated prescriptions, compared with normal weight (p < 0.01). For sertraline, there were no significant dose differences between individuals with overweight or obesity, compared with normal weight. However, pronounced differences were seen in dose per kilogram body weight in both first and iterated prescriptions (p < 0.01). We conclude that the doses of fluoxetine and sertraline were essentially similar in individuals with overweight or obesity, but the weight-normalized doses were clearly lower. Given the ongoing obesity epidemic, larger studies addressing optimal dosing in individuals with elevated weight are warranted.
Inferring social signals from the eyes in male schizophrenia
Authors: Resch Annika , Moosavi Jonas , Sokolov Alexander N. , Steinwand Patrick , Wagner Erika , Fallgatter Andreas J. , Pavlova Marina A. 
Published: November 2024

AbstractNonverbal communication habitually leaks out in ways that expose underlying thoughts, true feelings, and integrity of a counterpart. Social cognition is deficient in a wide range of mental disorders, including schizophrenia (SZ). Inferring social signals through the eyes is pivotal for social interaction but remains poorly investigated. The present work aims to fill this gap by examining whether and, if so, how reading language of the eyes is altered in SZ. We focused on male SZ, primarily because the disorder manifests a gender-specific profile. Patients and matched typically developing (TD) individuals were administered the Reading the Mind in the Eyes Test-Modified (RMET-M) and Emotions in Masked Faces (EMF) task that provide comparable visual information. The findings indicate that in SZ, the emotion recognition profile is similar to TD, with a more accurate recognition of some emotions such as fear, neutral expressions, and happiness than the others (sadness and disgust). In SZ, however, this profile is shifted down: all emotions are recognized less accurately than in TD. On the RMET-M, patients are also less precise, albeit they perform better on items with positive valence. In SZ only, recognition accuracy on both tasks is tightly linked to each other. The outcome reveals global challenges for males with SZ in inferring social information in the eyes and calls for remediation programs to shape social cognition. This work offers novel insights into the profiles of social cognitive deficits in mental disorders that differ in their gender prevalence.
A novel sustainable biocide against the fruit fly Drosophila suzukii made from orange peels
Authors: Barone Giovanni Davide , Hartbauer Manfred 
Published: November 2024

AbstractDrosophila suzukii (D. suzukii), a pervasive pest originating from Southeast Asia, presents a substantial risk to global agriculture. The ability of the female flies to lay eggs within fruits of varying maturity stages, combined with the accelerated offspring development within warmer climates, results in rapid population growth. This poses significant challenges for fruit production and viticulture, exacerbated by the increasing prevalence of pesticide resistance. We propose a solution to this growing issue using an attract-and-kill approach by making use of upcycled organic waste materials made from orange peels. Specifically, we have tested an innovative salty orange peel product (OPP) in a choice experiment, in which OPP and hydrogel (control) were made available to fruit flies in Petri dishes situated beneath red wine grapes. The number of dead flies in both Petri dishes were counted each day and fly maggots inside berries were extracted after four days. Since Petri dishes were covered with a red lid, flies only selected on the basis of olfactory cues. Our results showed a higher number of captured flies in Petri dishes containing OPP compared to those with the hydrogel control. Furthermore, a notable reduction in the number of maggots was observed inside grapes located above OPP compared to the grapes closer to the hydrogel control. Dilution of OPP was followed by a lower count of dead flies. In additional choice experiments, the concentration of NaCl was found to be positively correlated with the number of dead flies. This suggests an important lethal effect caused by high salt concentrations. In a final experiment, OPP was also compared to the commercially-available attractant called Drosalure™, which resulted in a slightly higher attractiveness of OPP to D. suzukii. These findings suggest that OPP holds potential as a cost-efficient and eco-friendly biocide made from organic waste material. OPP offered in attract-and-kill traps equipped with small entry holes is safe for bees and may replace other less eco-friendly control measures for D. suzukii in organic vineyards.
Synthesis and preliminary cytotoxicity evaluation of water soluble pentacyclic triterpenoid phosphonates
Authors: Lugiņina Jevgeņija , Kroškins Vladislavs , Lācis Rihards , Fedorovska Elza , Demir Öznur , Dubnika Arita , Loca Dagnija , Turks Māris 
Published: November 2024

AbstractSynthesis, solubility and cytotoxicity evaluation of anionic phosphonates derived from betulin, betulinic acid, oleanolic acid and ursolic acid is reported. Phosphonate moieties were successfully installed at terpenoid C28 by carboxylic acid deprotonation/alkylation sequence using (dimethoxyphosphoryl)methyl trifluoromethanesulfonate as alkylation reagent. Also, betulin-derived and ether-linked bis-phosphonate is obtained and characterized. After demethylation in the presence of TMSI the resulting phosphonic acids were transformed into their disodium salts. All target compounds display excellent water solubility, which was determined by qNMR in D2O. Cytotoxicity tests were performed in different concentrations of each compound (10–50 µM) against human osteosarcoma cell line MG-63 and osteoblast precursor cell line MC3T3-E1. Improved aqueous solubility and low cytotoxicity profile of the newly designed triterpenoid phosphonates reveal high potential for various medicinal chemistry and pharmacological applications in the future.
Development and validation of a dynamic nomogram for individualized prediction of survival in patients with colon cancer
Authors: Sun Yuting , Huang Longchang , Shen Xiaoming , Yang Zenghui , Xu Binghua , Bao Chuanqing , Shi Yifan 
Published: November 2024

AbstractCurrent tools for predicting survival outcomes in colon cancer patients predominantly rely on clinical and pathologic characteristics. However, accumulating evidence demonstrates a significant correlation between nutritional status and patient outcomes. This study aimed to establish a new dynamic nomogram for individualized prediction of postoperative overall survival (OS). The clinicopathological and nutritional data of colon cancer patients undergoing radical resection were retrospectively collected and randomly divided into the primary and validation cohorts. Risk factors on OS rates were investigated by Cox analyses and, the nomogram was constructed using significant predictors. Among 1,024 patients, 341 deaths were observed after median follow-up of 54 months. Five independent prognostic factors, including nutritional status assessments, were incorporated into the nomogram. The C-index regarding 1-, 3-, and 5-year OS were 0.830, 0.859, and 0.757 in the primary cohort and 0.843, 0.870, and 0.773 in the validation cohort, respectively. Calibration curves for the probability of OS exhibited an optimal agreement. Decision curve analyses revealed the greater application value of the nomogram than the TNM staging system. Based on the nomogram, patients could be stratified into three scenarios with significant prognostic classification (P < 0.0001). In conclusion, we developed and validated an easy-to-use dynamic nomogram for predicting postoperative OS in colon cancer patients.
Analysis of the impact of deep learning know-how and data in modelling neonatal EEG
Authors: Daly Aengus , Lightbody Gordon , Temko Andriy 
Published: November 2024

AbstractThe performance gains achieved by deep learning models nowadays are mainly attributed to the usage of ever larger datasets. In this study, we present and contrast the performance gains that can be achieved via accessing larger high-quality datasets versus the gains that can be achieved from harnessing the latest deep learning architectural and training advances. Modelling neonatal EEG is particularly affected by the lack of publicly available large datasets. It is shown that greater performance gains can be achieved from harnessing the latest deep learning advances than using a larger training dataset when adopting AUC as a metric, whereas using AUC90 or AUC-PR as metrics greater performance gains are achieved from using a larger dataset than harnessing the latest deep learning advances. In all scenarios the best performance is obtained by combining both deep learning advances and larger datasets. A novel developed architecture is presented that outperforms the current state-of-the-art model for the task of neonatal seizure detection. A novel method to fine-tune the presented model towards site-specific settings based on pseudo labelling is also outlined. The code and the weights of the model are made publicly available for benchmarking future model performances for neonatal seizure detection.
Unraveling neuroprotection with Kv1.3 potassium channel blockade by a scorpion venom peptide
Authors: Beraldo-Neto Emidio , Ferreira Vanessa Florentino , Vigerelli Hugo , Fernandes Karolina Rosa , Juliano Maria Aparecida , Nencioni Ana Leonor Abrahao , Pimenta Daniel Carvalho 
Published: November 2024

AbstractVoltage-gated potassium channels play a crucial role in cellular repolarization and are potential therapeutic targets in neuroinflammatory disorders and neurodegenerative diseases. This study explores Tityus bahiensis scorpion venom for neuroactive peptides. We identified the αKtx12 peptide as a potent neuroprotective agent. In SH-SY5Y cells, αKtx12 significantly enhances viability, validating its pharmacological potential. And in the animal model, we elucidate central nervous system (CNS) mechanism of αKtx12 through neuroproteomic analyses highlighting αKtx12 as a valuable tool for characterizing neuroplasticity and neurotropism, revealing its ability to elicit more physiological responses. The peptide’s potential to promote cell proliferation and neuroprotection suggests a role in functional recovery from nervous system injury or disease. This research unveils the neuroactive potential of scorpion venom-derived αKtx12’s, offering insights into its pharmacological utility. The peptide’s impact on neuronal processes suggests a promising avenue for therapeutic development, particularly in neurodegenerative conditions.
Using data from cue presentations results in grossly overestimating semantic BCI performance
Authors: Rybář Milan , Poli Riccardo , Daly Ian 
Published: November 2024

AbstractNeuroimaging studies have reported the possibility of semantic neural decoding to identify specific semantic concepts from neural activity. This offers promise for brain-computer interfaces (BCIs) for communication. However, translating these findings into a BCI paradigm has proven challenging. Existing EEG-based semantic decoding studies often rely on neural activity recorded when a cue is present, raising concerns about decoding reliability. To address this, we investigate the effects of cue presentation on EEG-based semantic decoding. In an experiment with a clear separation between cue presentation and mental task periods, we attempt to differentiate between semantic categories of animals and tools in four mental tasks. By using state-of-the-art decoding analyses, we demonstrate significant mean classification accuracies up to 71.3% during cue presentation but not during mental tasks, even with adapted analyses from previous studies. These findings highlight a potential issue when using neural activity recorded during cue presentation periods for semantic decoding. Additionally, our results show that semantic decoding without external cues may be more challenging than current state-of-the-art research suggests. By bringing attention to these issues, we aim to stimulate discussion and drive advancements in the field toward more effective semantic BCI applications.