bluuebunny/crossref_metadata_2025_split huggingface dataset:
Vergleich der Bildqualität zweier unterschiedlicher OCT-Angiografie-Systeme mit Fokus auf Bewegungsartefakten bei gesunden Probanden
Authors: Mihailovic Natasa , Lauermann Jost Lennart , Schubert Friederike , Lahme Larissa , Treder Maximilian , Alten Florian , Eter Nicole , Alnawaiseh Maged 
Published: April 2019

Zusammenfassung
Hintergrund Die vorliegende Studie vergleicht die Ausprägung von Bewegungsartefakten bei Aufnahmen der optischen Kohärenztomografie-Angiografie (OCT-A) bei gesunden Probanden zwischen 2 OCT-A-Systemen verschiedener Hersteller mit unterschiedlicher technischer Ausstattung.
Methodik In dieser Arbeit wurden 25 Augen von 25 gesunden Probanden (19 weiblich, mittleres Alter 31,12 ± 11,95 Jahre) ohne bestehende Augenerkrankungen oder zurückliegende Augenoperationen eingeschlossen. OCT-A-Aufnahmen wurden mit dem RTVue XR Avanti (Optovue Inc., Fremont, Kalifornien, USA) sowie mit dem Spectralis OCT-A-Modul (Heidelberg Engineering, Heidelberg, Deutschland) durchgeführt. In jeweils 2 Messungen der Makula (Optovue: 3 × 3 mm², äquivalent Heidelberg: 10 × 10°) je Proband mit aktivem Eye Tracking (ET) wurde die Ausprägung von Bewegungsartefakten im superfiziellen OCT-Angiogramm anhand eines Motion Artifact Scores (MAS) von 2 unabhängigen Readern erfasst.
Ergebnisse Die Signalstärke (signal strength index, SSI) lag im Mittel bei 73,0 ± 7,8 (Optovue) und 39,6 ± 3,6 (Heidelberg), dies entsprach beim Optovue 73,0% des theoretischen Bestwerts (SSImax = 100 = 100%) und beim Heidelberg 79,2% der höchstmöglichen SSI (SSImax = 50 = 100%). Beide Geräte zeigten eine insgesamt geringe Artefaktausprägung mit einem entsprechend niedrigen MAS (mittlerer MAS [Optovue]: 1,32 ± 0,551; mittlerer MAS [Heidelberg]: 1,7 ± 0,789; p = 0,006). Die Übereinstimmung zwischen den beiden Readern lag bei beiden Geräten bei 88%. Ein Quilting/Banding zeigte sich in 20% (10/50, Optovue), resp. 6% (3/50, Heidelberg) aller Messungen, ein Stretching in 4% (2/50, Optovue) und in 6% (3/50, Heidelberg). Ein Vessel Doubling und Displacement zeigte sich jeweils in einer Optovue-Aufnahme (2%) und bei keiner Heidelberg-Aufnahme (0%). Blink Lines hingegen waren in 3 Heidelberg-Aufnahmen (6%) und in keiner Optovue-Aufnahme auffindbar (0%).
Schlussfolgerung Beide Geräte ermöglichen trotz unterschiedlicher Soft- und Hardware im vorliegenden Kollektiv Aufnahmen mit nur geringer Ausprägung von Bewegungsartefakten. Jedoch kommen diese auch bei gesunden Probanden mit guter Fixation vor. Ferner zeigte sich eine hohe Übereinstimmung bei der Bildbeurteilung in Bezug auf den MAS zwischen den beiden Readern. Dennoch bleibt die Analyse von Bewegungsartefakten komplex und erfordert eine gewisse Erfahrung und genaue Betrachtung bei der Bewertung von OCT-A-Aufnahmen.
Sicherheit geht vor – Evaluation von IOL-Injektorsystemen
Authors: Borkenstein Andreas F. , Borkenstein Eva-Maria 
Published: April 2019

Zusammenfassung
Hintergrund Der Fortschritt in der Kataraktchirurgie brachte vorgeladene IOL-Implantationssysteme auf den Markt. Diese sollen die OP-Gesamtzeit sicher und effektiv verkürzen. Im Rahmen dieser Studie wurde die Sicherheit und Handlichkeit des 2-Komponenten-Autoloading-Systems SAFELOADER® (HumanOptics AG, Erlangen, Deutschland) bewertet und mit 2 anderen Systemen verglichen.
Material und Methoden Insgesamt wurden 167 Augen in die monozentrische prospektive Studie eingeschlossen. In 67 Augen wurden die IOLs durch das SAFELOADER-System, in 50 Augen durch ein Fully-preloaded-System (TECNIS iTec® Preloaded Delivery System, Johnson & Johnson Vision, Santa Ana, CA, USA) und in 50 Augen durch ein manuelles System (UNFOLDER® Platinum 1 Series Delivery System, Johnson & Johnson Vision, Santa Ana, CA, USA) implantiert. Für jedes Verfahren wurden die IOL-Vorbereitungszeit und die Implantationszeit in Sekunden festgehalten. Der OP-Ablauf sowie die Handhabung durch den Arzt und die OP-Schwester wurden bewertet.
Ergebnisse Der SAFELOADER und iTec sind schneller und handlicher als der UNFOLDER. Die Vorbereitungszeit des SAFELOADER war mit einem Median von 6,5 Sekunden (s) (5,3 – 6,9) ca. 1 s länger (p < 0,0001) als die des iTec-Systems mit 5,2 s (4,5 – 6,5). Beide waren signifikant (p < 0,0001) schneller als der manuelle UNFOLDER mit 26,9 s (20,6 – 30,1). Bei Betrachtung der reinen Implantationszeit gab es kaum Unterschiede zwischen SAFELOADER mit 7,2 s (5,3 – 8,6), iTec mit 7,3 s (5,9 – 8,3) und UNFOLDER mit 7,2 s (5,9 – 7,6). Im gesamten OP-Ablauf schnitten SAFELOADER mit einer Note von 2,0 (1,0 – 3,0) und iTec 1,0 (1,0 – 3,0) deutlich (p < 0,0001) besser ab als das manuelle System mit 5,0 (3,0 – 5,0). Der Arzt empfand die Handhabung des SAFELOADER und des iTec (beide Median 1,0; 1,0 – 2,0) signifikant (p < 0,0001) besser als die des UNFOLDER (2,5; 1,0 – 4,0). Für die OP-Schwester schnitt der SAFELOADER mit 1,0 (1,0 – 2,0) signifikant (p < 0,0001) besser ab als iTec mit 2,0 (1,0 – 3,0) und der UNFOLDER mit 4,0 (2,0 – 5,0).
Schlussfolgerung Das 2-Komponenten-Autoloading-System SAFELOADER® ist intuitiv zu handhaben, schnell und effektiv in der Anwendung und bietet ein hohes Maß an Sicherheit.
Significantly lower annual rates of neoplastic progression in short- compared to long-segment non-dysplastic Barrett’s esophagus: a systematic review and meta-analysis
Authors: Chandrasekar Viveksandeep Thoguluva , Hamade Nour , Desai Madhav , Rai Tarun , Gorrepati Venkata Subhash , Jegadeesan Ramprasad , Sathyamurthy Anjana , Sharma Prateek 
Published: April 2019

Abstract
Background Although shorter lengths of Barrett’s esophagus (BE) have been associated with a lower risk of neoplastic progression, precise estimates have varied, especially for non-dysplastic BE (NDBE) only. Therefore, current US guidelines do not provide specific recommendations on surveillance intervals based on BE length. We performed a systematic review and meta-analysis of the published literature to examine neoplastic progression rates of NDBE based on BE length.
Methods PubMed, Cochrane, Google Scholar, and Embase were comprehensively searched. Studies reporting progression rates in patients with NDBE and > 1 year of follow-up were included. The number of patients progressing to esophageal adenocarcinoma (EAC) and high grade dysplasia (HGD)/EAC in individual studies and the mean follow-up were recorded to derive person-years of follow-up. Pooled rates of progression to EAC and HGD/EAC based on BE length (< 3 cm vs. ≥ 3 cm) were calculated.
Results Of the 486 initial studies identified, 10 met the inclusion/exclusion criteria. These included a total of 4097 NDBE patients; 1979 with short-segment BE (SSBE; 10 773 person-years of follow-up) and 2118 with long-segment BE (LSBE; 12 868 person-years). The annual rates of progression to EAC were significantly lower for SSBE compared with LSBE: 0.06 % (95 % confidence interval 0.01 % – 0.10 %) vs. 0.31 % (0.21 % – 0.40 %), respectively; odds ratio (OR) 0.25 (0.11 – 0.56); P < 0.001, as were the rates for the combined endpoint (HGD/EAC): 0.24 % (0.09 % – 0.32 %) vs. 0.76 % (0.43 % – 0.89 %), respectively; OR 0.35 (0.21 – 0.58); P < 0.001. There was no significant heterogeneity among studies.
Conclusion The results demonstrate significantly lower rates of neoplastic progression in NDBE patients with SSBE compared with LSBE. BE length can easily be used for risk stratification purposes for NDBE patients undergoing surveillance endoscopy and consideration should be given to tailoring surveillance intervals based on BE length in future US guidelines.
Diverting Ostomy: For Whom, When, What, Where, and Why
Authors: Plasencia Alexis , Bahna Heidi 
Published: April 2019

AbstractFecal diversion is an important tool in the surgical armamentarium. There is much controversy regarding which clinical scenarios warrant diversion. Throughout this article, we have analyzed the most recent literature and discussed the most common applications for the use of a diverting stoma. These include construction of diverting ileostomy or colostomy, ostomy for low colorectal/coloanal anastomosis, inflammatory bowel disease, diverticular disease, and obstructing colorectal cancer. We conclude the following: diverting loop ileostomy is preferred to loop colostomy, an ostomy should be used for a pelvic anastomosis < 5 to 6 cm including coloanal anastomosis and ileo-anal-pouch anastomosis, severe perianal Crohn's disease frequently requires diversion, a primary anastomosis with diverting ileostomy in the setting of diverticular perforation is safe, and a diverting stoma can be used as a bridge to primary resection in the setting of an obstructing malignancy.
Health Care Policy and Outcomes after Colon and Rectal Surgery: What Is the Bigger Picture?—Cost Containment, Incentivizing Value, Transparency, and Centers of Excellence
Authors: Bhama Anuradha , Holubar Stefan , Delaney Conor 
Published: April 2019

AbstractEarly in the 21st century, the costs of health care in the United States have spiraled out of control, where the per capita spending is $9,237 per person—the highest in the world. By 2020, an estimated 20% of GDP will be spent on health care. The issue of cost and quality is now becoming a national crisis, with ∼50% of hospitals losing money on clinical operations, forcing closure of essential critical access hospitals, and forcing health care workers to relocate or change professions. This crisis will only worsen with the graying of America, as an estimated 17% of Americans will be over the age of 65 years by the year 2020. The policy and financial structures on which these changes are based are important factors of which practicing surgeons should be aware. This review discusses recent national health care policy reform and specific topics including cost-containment legislation, value-based incentives and penalties, transparency, and centers of excellence in colorectal surgery.
Abdominal Cutaneous Nerve Entrapment Syndrome, Case Report and Diagnostic Evaluation
Authors: Guedes-Correa Jose Fernando , Bulhões Stephanie Oliveira Fernandes de 
Published: April 2019

Abdominal cutaneous nerve entrapment is a rarely diagnosed condition that leads to intense neuropathic pain in the anterolateral wall of the abdomen. Generally, it is triggered by some factor implied in the increase of the pressure on the nerve in its passage by the abdominal wall. Its most important differential diagnosis is pain of visceral origin.We present a case in which the clinical findings confirmed on ultrasound and other imaging tests established the diagnosis and in which the noninvasive treatment was effective.
Endovascular Treatment in the Subclavian Steal Syndrome
Authors: Gatto Luana Antunes Maranha , Chaves Jennyfer Paulla Galdino , Mendes Cássio Henrique , Seabra Diego do Monte Rodrigues , Koppe Gelson Luis , Demartini Junior Zeferino 
Published: April 2019

AbstractWhen the proximal occlusion or stenosis of the subclavian or of the brachiocephalic artery may require distal arterial filling through reversal flow from the vertebral artery, causing clinically significant blood supply reduction to the brainstem, it is called subclavian steal syndrome (SSS). We report a 54-year-old male patient who presented with multiple episodes of syncopes and vascular claudication due to right SSS. He underwent an angioplasty, evolving with complete improvement of the symptoms. We review the clinical presentation, the diagnostic methods, and the treatment options of the disease.
Usage of a Translated Version of Terminologia Anatomica in Brazil: An Examination of the Neurosurgical Literature
Authors: Lessa Krysna Pires , Vilasbôas Ítalo Gonçalo Matias , Aquino Marcos de Amorim , Maldonado Igor Lima 
Published: April 2019

Introduction The linguistic factor may have delayed the universal adoption of the International Anatomical Terminology (IAT), which was widespread in Latin and in English only. Independent translations are possible, but they are not devoid of methodological difficulties.
Objective To estimate the usage of the translated version of the Terminologia Anatomica in neurosurgical articles in Brazil.
Method Consecutive national publications were checked for the correspondence of their anatomical terms to the following categories: IAT – Brazilian version; IAT in Latin; Nomina Anatomica – previous versions; incomplete terms; derivative terms; eponyms; neologisms; and others (misspellings and prosaic terms). The years 2014 and 2015 were chosen for analysis so that included articles were published at least 16 years after the publication of the original IAT (1998) and at least 13 years since the publication of the Brazilian version (2001).
Results Out of a total of 183 articles analyzed, 1,132 anatomical terms were identified, referring to 334 different anatomical structures. Most of the structures were described using terms from the Brazilian version of the IAT (n = 834; 73.7%). Those that did not belong to or did not derive from any version of the IAT totaled 281 (24.8%). The remaining 17 terms (1.5%) corresponded to words derived or provided for in the Latin IAT. No association was identified between the number of authors and any category of nomenclature.
Conclusion Although most anatomical structures cited in Portuguese were described in accordance with the Brazilian version of the IAT, the degree of adherence was considered moderate given that about one-quarter of the terms escaped this terminology.
A De Novo Dominant Negative Mutation in DNM1L Causes Sudden Onset Status Epilepticus with Subsequent Epileptic Encephalopathy
Authors: Schmid S. , Wagner M. , Goetz C. , Makowski C. , Freisinger P. , Berweck S. , Mall V. , Burdach S. , Juenger H. 
Published: April 2019

AbstractMitochondrial dynamics such as fission and fusion play a vital role in normal brain development and neuronal activity. DNM1L encodes a dynamin-related protein 1 (Drp1), which is a GTPase essential for proper mitochondrial fission. The clinical phenotype of DNM1L mutations depends on the degree of mitochondrial fission deficiency, ranging from severe encephalopathy and death shortly after birth to initially normal development and then sudden onset of refractory status epilepticus with very poor neurologic outcome. We describe a case of a previously healthy 3-year-old boy with a mild delay in speech development until the acute onset of a refractory status epilepticus with subsequent epileptic encephalopathy and very poor neurologic outcome. The de novo missense mutation in DNM1L (c.1207C > T, p.R403C), which we identified in this case, seems to determine a unique clinical course, strikingly similar to four previously described patients in literature with the identical de novo heterozygous missense mutation in DNM1L.
The mixed effects of online diversity training
Authors: Chang Edward H. , Milkman Katherine L. , Gromet Dena M. , Rebele Robert W. , Massey Cade , Duckworth Angela L. , Grant Adam M. 
Published: April 2019

Significance
Although diversity training is commonplace in organizations, the relative scarcity of field experiments testing its effectiveness leaves ambiguity about whether diversity training improves attitudes and behaviors toward women and racial minorities. We present the results of a large field experiment with an international organization testing whether a short online diversity training can affect attitudes and workplace behaviors. Although we find evidence of attitude change and some limited behavior change as a result of our training, our results suggest that the one-off diversity trainings that are commonplace in organizations are not panaceas for remedying bias in the workplace.
Pejvakin-mediated pexophagy protects auditory hair cells against noise-induced damage
Authors: Defourny Jean , Aghaie Alain , Perfettini Isabelle , Avan Paul , Delmaghani Sedigheh , Petit Christine 
Published: April 2019

Significance
Noise-induced hearing loss is a highly prevalent form of sensorineural hearing impairment affecting individuals of all ages. Noise exposure triggers a rapid increase in reactive oxygen species (ROS) levels, causing oxidative damage to auditory hair cells and resulting in hearing loss. Here we describe a novel mechanism of protection against noise-induced auditory hair cell damage. In response to sound exposure, pejvakin, a peroxisome-associated protein, acts as an ROS sensor and recruits the autophagy machinery to trigger the degradation of peroxisomes (pexophagy) damaged by oxidative stress. We characterized the pejvakin interactions involved in this process. We provide evidence that pejvakin-mediated pexophagy plays a key role in controlling peroxisome proliferation and protecting auditory hair cells against noise-induced damage.
Improved enantioselectivity of E. coli BioH in kinetic resolution of methyl (S)-3-cyclohexene-1-carboxylate by combinatorial modulation of steric and aromatic interactions
Authors: Wu Xiafen , Yang Shengli , Yu Hongwei , Ye Lidan , Su Bingmei , Shao Zehui 
Published: April 2019

ABSTRACT
As a chiral precursor for the important anticoagulant Edoxaban, enantioselective synthesis of (S)-3-cyclohexene-1-carboxylic acid is of great significance. The complicated procedures and generation of massive solid waste discourage its chemical synthesis, and the alternative biocatalysis route calls for an enzyme capable of asymmetric hydrolysis of racemic methyl-3-cyclohexene-1-carboxylate. To this end, we engineered the E. coli esterase BioH for improved S-enantioselectivity via rational design. By combinatorial modulation of steric and aromatic interactions, a positive mutant Mu3 (L24A/W81A/L209A) with relatively high S-selectivity in hydrolyzing racemic methyl-3-cyclohexene-1-carboxylate was obtained, improving the enantiomeric excess from 32.3% (the wild type) to 70.9%. Molecular dynamics simulation was conducted for both (R)- or (S)- complexes of the wild type and Mu3 to provide hints for the mechanism behind the increased S-selectivity. Moreover, the reaction conditions of Mu3 in methyl-3-cyclohexene-1-carboxylate hydrolysis was optimized to improve the conversion rate to 2 folds.
Time-Varying Exposure to Ozone and Risk of Stillbirth in a Nonattainment Urban Region
Authors: Rammah Amal , Whitworth Kristina W , Han Inkyu , Chan Wenyaw , Symanski Elaine 
Published: April 2019

Abstract
In a racially and ethnically diverse urban area (Harris County, Texas) with historic nonattainment O3 levels, we obtained birth and fetal death records from 2008–2013 and estimated maternal residential O3 concentrations from conception until delivery using inverse-distance interpolation from the local air monitoring network. We examined multipollutant models (with fine particulate matter and nitrogen dioxide) and effect measure modification by race/ethnicity and length of gestation. We found a 9% (95% confidence interval (CI): 1, 18) increased stillbirth risk associated with a 3.6-parts-per-billion increase in O3 exposure. The risk was higher among women with pregnancies of <37 gestational weeks (hazard ratio (HR) = 1.13, 95% CI: 1.04, 1.23) compared with women with pregnancies of longer gestation (HR = 1.05, 95% CI: 0.87, 1.27) and among Hispanic women (HR = 1.14, 95% CI: 1.02, 1.27). We also conducted a case-crossover analysis and detected no associations with short-term exposure. To our knowledge, this study is the first to use time-to-event analyses to examine stillbirth risk associated with time-varying prenatal ozone (O3) exposure over pregnancy. Our findings indicate that maternal O3 exposure over pregnancy is associated with stillbirth risk and that Hispanic women and women with shorter pregnancies might be at particular risk.
American Association for Accreditation of Ambulatory Surgical Facilities (AAAASF) History: Its Role in Plastic Surgery Safety
Authors: Singer Robert , Keyes Geoffrey R , Nahai Foad 
Published: April 2019

Abstract
From its origin cosmetic surgery was performed in facilities which were neither certified nor regulated. Recognizing that there was no formal oversight of facilities, a group of plastic surgeons saw the need to develop an accreditation program. This eventually evolved into the American Association for Accreditation of Ambulatory Plastic Surgery Facilities. The organization was started to implement and maintain a voluntary inspection accreditation program for qualifying surgical facilities. Its focus was to educate plastic surgeons on safety and became recognized as the gold standard for accreditation. Seeing the need for similar standards for all surgeons, it morphed into the American Association for Accreditation of Ambulatory Surgery Facilities (AAAASF). Comprehending that accreditation was in everyone’s best interest, AAAASF developed educational formats for plastic surgeons, testified at the US Congress suggesting potential ways that oversight of facilities could improve patient safety, functioned as a resource to numerous states in developing guidelines for oversight of facilities, continued to update its standards, and extended its accreditation program internationally. Recognizing the value of accreditation, proven by AAAAASF’s extensive database from its Internet-Based Quality Assurance Program, the American Society for Aesthetic Plastic Surgery (ASAPS) and the American Society of Plastic Surgeons (ASPS) mandated that its members operate only in accredited or licensed facilities. Numerous studies documenting the safety of accredited plastic surgical facilities from AAAASF’s extensive quality assurance and peer-review reporting program are cited. AAAASF played a significant role and will continue to do that in producing better, safer environments for outpatient surgical procedures.
Facing death together: heterospecific aggregations of blowfly larvae evince mutual benefits
Authors: Komo Larissa , Scanvion Quentin , Hedouin Valéry , Charabidze Damien 
Published: April 2019

AbstractHeterospecific aggregations and foraging associations have been observed between different species, from apes to birds to insects. Such associations are hypothesized to result in a mutually beneficial relationship entailing benefits that are not apparent in conspecific groupings. Therefore, the objectives of the present study were to investigate 1) how 3 blowfly species, namely, Calliphora vicina, Calliphora vomitoria, and Lucilia sericata, aggregate according to species, and 2) if developmental benefits are linked to heterospecific aggregation. For objective (1), larvae of 2 species were placed between 2 conspecific aggregates, each with a different species (i.e., a binary choice test). After 20 h, the positions of all larvae were determined. On average, 98% of the maggots added later settled together on one of the 2 pre-existing aggregations, demonstrating a collective choice. The aggregation spot with C. vicina was preferred against others, indicating different attractiveness of different species. To relate this behavior to its benefits (objective ii), C. vicina and L. sericata larvae were raised from first instar to adult in con- and heterospecific conditions, and their development time, mortality rates, and morphometrics were measured. Thereby, mutual and asymmetric consequences were observed: specifically, there were significant increases in size and survival for L. sericata and faster development for C. vicina in heterospecific groups. These results indicate that the predilection for heterospecific association leads to mutual developmental benefits. This heterospecific aggregation behavior may be a resource-management strategy of blowflies to face carrion-based selection pressure.