bluuebunny/crossref_metadata_2025_split huggingface dataset:
Population segmentation based on healthcare needs: a systematic review
Authors: Chong Jia Loon , Lim Ka Keat , Matchar David Bruce 
Published: August 2019

Abstract
Background
Healthcare needs-based population segmentation is a promising approach for enabling the development and evaluation of integrated healthcare service models that meet healthcare needs. However, healthcare policymakers interested in understanding adult population healthcare needs may not be aware of suitable population segmentation tools available for use in the literature and barring better-known alternatives, may reinvent the wheel by creating and validating their own tools rather than adapting available tools in the literature. Therefore, we undertook a systematic review to identify all available tools which operationalize healthcare need-based population segmentation, to help inform policymakers developing population-level health service programmes.

Methods
Using search terms reflecting concepts of population, healthcare need and segmentation, we systematically reviewed and included articles containing healthcare need-based adult population segmentation tools in PubMed, CINAHL and Web of Science databases. We included tools comprising mutually exclusive segments with prognostic value for clinically relevant outcomes. An updated secondary search on the PubMed database was also conducted as the last search was conducted 2 years ago. All identified tools were characterized in terms of segment formulation, segmentation base, whether they received peer-reviewed validation, requirement for comprehensive electronic medical records, proprietary status and number of segments.

Results
A total of 16 unique tools were identified from systematically reviewing 9970 articles. Peer-reviewed validation studies were found for 9 of these tools.

Discussion and conclusions
The underlying segmentation basis of most identified tools was found to be conceptually comparable to each other which suggests a broad recognition of archetypical patient overall healthcare need profiles. While many tools operate based on administrative record data, it is noted that healthcare systems without comprehensive electronic medical records would benefit from tools which segment populations through primary data collection. Future work could therefore include development and validation of such primary data collection-based tools. While this study is limited by exclusion of non-English literature, the identified and characterized tools will nonetheless facilitate efforts by policymakers to improve patient-centred care through development and evaluation of services tailored for specific populations segmented by these tools.
Complete Resolution of Sellar Metastasis in a Patient With NSCLC Treated With Osimertinib
Authors: Fan WuQiang , Sloane Jason , Nachtigall Lisa B 
Published: August 2019

Abstract
Non–small cell lung cancer with pituitary metastasis (NSCLC-PM) is a devastating disease; however, treatment is being revolutionized by a novel therapy targeting highly specific tumor signals, such as the mutation of epidermal growth factor receptors (EGFRs). Long-term management of hormonal defects in this population has become a unique neuroendocrine clinical challenge. We report the case of a 73-year-old female nonsmoker who was diagnosed with stage IV non–small cell lung cancer. The initial staging evaluation revealed a 7 × 11 × 21-mm sellar lesion abutting the optic chiasm and causing clinical hypopituitarism. The patient received three cycles of chemotherapy with carboplatin and pemetrexed, which was discontinued because of major cumulative side effects of myelosuppression and kidney disease. Eight months later, scans demonstrated evidence of disease progression. A repeated lung nodule biopsy revealed an EGFR exon 19 deletion mutation. EGFR-targeted therapy with osimertinib 80 mg daily was initiated. A complete resolution of the pituitary lesion was evident on a follow-up pituitary MRI 5 weeks later and was sustained 1 year after. However, the panhypopituitarism persisted. This is an illustrative case of NSCLC-PM with EGFR exon 19 deletion mutation, wherein osimertinib, a third-generation EGFR‒tyrosine kinase inhibitor, eradicated the sellar metastasis and prevented the need for radiotherapy. However, the neuroendocrine deficits persisted despite anatomic improvement.
Atypical Tibial Fracture in a 63-Year-Old Woman With Intermittent Use of Bisphosphonate Unmasking Hypophosphatasia
Authors: Malabu Usman H , Lockett Jack , Lyster Emma , Maguire John , Tan YongMong 
Published: August 2019

Abstract
We report an unusual case of atypical proximal tibial stress fracture (APTF) associated with intermittent use of bisphosphonates (BPs) and persistently low serum alkaline phosphatase (ALP) levels. We describe the case of a 63-year-old white woman who had experienced an APTF after 4 years of intermittent exposure to alendronate given for recurrent metatarsal stress fractures. BP administration was stopped after the diagnosis of the APTF. A review of her previous serum ALP levels revealed they had been consistently low. Adult hypophosphatasia (HPP) was diagnosed by the low serum ALP activity and elevated urine phosphoethanolamine levels. She was treated conservatively with analgesics. Adult HPP is an underrecognized condition associated with atypical insufficiency fractures, and BP use compounds this risk. To the best of our knowledge, we report the first case of intermittent BP exposure preceding an APTF in an adult patient with HPP, highlighting the uncommon site of the proximal tibia for BP-associated atypical insufficiency fractures, the need to screen for HPP in those with persistently low ALP levels before they begin BP therapy, and the importance of avoiding BP use in those with HPP.
Trans/Criptions
Authors: Thornton Max 
Published: August 2019

Abstract
Phenomenological theology can provide a helpful reframing of the bodily rituals of transgender and disabled experience, embracing the ways in which they waste time and energy and sacralizing this waste as a microtactic of resistance to oppression and a site for the in-breaking of the transcendent in the everyday. Using Rosemarie Garland-Thomson's model of the misfit, trans and disabled experience can be understood as a temporal misfitting under the cis and abled norms of neoliberal capitalism, which seeks to contain, suppress, or eliminate their inefficient, flexible, and waste time. A coalitional politics of trans/crip misfitting must resist the capacitating imperatives of normative time, instead leaning into the rupture created by trans/crip time as a space-time of potentiality and openness to alterity. The theological thought of Jean-Yves Lacoste can help frame the little rituals and bodily practices of trans and crip life as de Certeauvian microtactics that embody resistance to the coercions of neoliberal capitalism and, through their very frustration and difficulty, as sites of possibility for true liturgical experience.
Levush Project
Authors: Waxman Tobaron 
Published: August 2019

Abstract
The Levush Project is a series of originally designed hand-fabricated textiles consisting only of syringes and pharmaceutical packaging for testosterone treatments Tobaron Waxman used since the early 2000s. The focus of the project is the research and development of these textiles, for creation of wearable artworks to be worn in choreographic and vocal performances.
Embracing Inherent Chaos
Authors: Domenack Damien Pascal 
Published: August 2019

Abstract
In The Soul of the Stranger, Joy Ladin centers nonbinary gender expression in the first chapter of Genesis. Ladin articulates the opportunity for nonbinary gender categories by moving beyond the creation of the binary and focusing on Adam (humanity), who represents the whole of humanity. This review expands and creates an entry point for interreligious dialogue with African diasporic religions, by acknowledging humanity as a part of the interconnected balance of nature and recognizing the influence the Babylonian creation story, Enuma Elish, had on the the deep primordial oceanic chaos described as tehon in the Torah.
God&gt;Cursing&gt;Shaming&gt;Blessing&gt;Pride
Authors: Goh Joseph N. 
Published: August 2019

Abstract
This response to Joy Ladin's work attempts to articulate how a reconceptualization of God in terms of a “cursing” and “shaming” God might be theologically helpful. Rather than understanding God as cursing transgender people who ought to be ashamed of themselves, this response investigates what it is that God might curse, shame, bless, and bring to pride in relation to transgender people.
On Genesis
Authors: Bychowski M. W. 
Published: August 2019

Abstract
In this roundtable response to Joy Ladin's “Genesis of Gender,” the author affirms the possibilities for a theology of liberation arising from the book of Genesis but places a greater emphasis on humanity's cocreative and subcreative role in generation of gender. The author unpacks the act of naming in Genesis 2, specifically God's instruction for humanity to assign names to animals as the first act in a series of assigning meaning, associations, and genders to creation. The author argues that this role is complicated by the command to increase and multiply, which expands and transforms both creation and subcreative names of gender. This dynamism in creation and subcreation should prompt the regular liberation from inaccurate and oppressive gender identities, allowing for a greater degree of self-naming and self-composition.
Reliability of computed tomography-based renal cortex volume to determine split renal function in preoperative living kidney donors
Authors: Surawech Chuthaporn , Sasiwimonphan Kewalee 
Published: August 2019

Objective: The purpose of this study was to assess the utility of CT-based renal cortex volume to estimate split renal function (SRF) in pre-transplant living kidney donors and to evaluate its reliability to predict graft function in the recipients. Methods: Our study recruited all adult potential donors who had both Tc-99m-diethylenetriamine pentacetate (DTPA) scintigraphy and CT angiography of the abdominal aorta done before donating their kidney. We compared the correlation between CT-based renal cortex volume combined with kidney function and DTPA scan as well as post-donation kidney function in the recipients. Results: The correlation between CT-based split cortex volume and DTPA-measured SRF before transplantation was strong (intraclass correlation coefficient = 0.954–0.968). The inter-rater reliability of two radiologists also showed substantial agreement (intraclass correlation coefficient = 0.97, p < 0.001). In contrast, the correlations between renal cortical volume of donated kidney adjusted to recipient body weight and recipient kidney function was poor at both 2 week and 2 year follow-up. Conclusion: CT-based renal cortex volume combined with pre-operative kidney function appears to be precise and reproducible to evaluate pre-transplant SRF. Nevertheless, the prediction of recipient graft function needs to be further investigated to ensure a good outcome. Advances in knowledge: This method is practicable for all potential donors who undergo kidney transplantation in terms of streamline donor workup without compromising information.
Effect of micro-computed tomography reconstruction protocols on bone fractal dimension analysis
Authors: Gaêta-Araujo Hugo , Oliveira-Santos Nicolly , Brasil Danieli Moura , do Nascimento Eduarda Helena Leandro , Madlum Daniela Verardi , Haiter-Neto Francisco , Oliveira-Santos Christiano de 
Published: August 2019

Objectives: To evaluate the influence of the level of three micro-CT reconstruction tools: beam-hardening correction (BHC), smoothing filter (SF), and ring artefact correction (RAC) on the fractal dimension (FD) analysis of trabecular bone. Methods: Five Wistar rats’ maxillae were individually scanned in a SkyScan 1174 micro-CT device, under the following settings: 50 kV, 800 µA, 10.2 µm voxel size, 0.5 mm Al filter, rotation step 0.5°, two frames average, 180° rotation and scan time of 35 min. The raw images were reconstructed under the standard protocol (SP) recommended by the manufacturer, a protocol without any artefact correction tools (P0) and 35 additional protocols with different combinations of SF, RAC and BHC levels. The same volume of interest was established in all reconstructions for each maxilla and the FD was calculated using the Kolmogorov (box counting) method. One-way ANOVA with Dunnet’s post-hoc test was used to compare the FD of each reconstruction protocol (P0–P35) with the SP (α = 5%). Multiple linear regression verified the dependency of reconstruction tools in FD. Results: Overall, FD values are not dependent on RAC (p = 0.965), but increased significantly when the level of BHC and SF increased (p < 0.001). FD values from protocols with BHC at 45% combined with SF of 2, and BHC at 30% combined with SF of 4 or 6 had no statistical difference compared to SP. Conclusions: BHC and SF tools affect the FD values of micro-CT images of the trabecular bone. Therefore, these reconstruction parameters should be standardized when the FD is analyzed.
Post-stroke cognition with the Oxford Cognitive Screen vs Montreal Cognitive Assessment: a multi-site randomized controlled study (OCS-CARE)
Authors: Demeyere Nele , Sun Shuo , Milosevich Elise , Vancleef Kathleen 
Published: August 2019

Background: Cognitive impairment is common following stroke. The Oxford Cognitive Screen (OCS) was designed to assess focal post-stroke cognitive deficits in five domains. Here, we investigated whether results generated by the OCS vs the domain-general Montreal Cognitive Assessment (MoCA) at baseline impacted patient outcomes at 6 months follow-up. Methods: Patients <2 months post-stroke were randomized to receive either the OCS and corresponding information leaflet or standard care with the MoCA at baseline. After 6 months, patients received both the OCS and MoCA. The primary registered outcome measures were the Stroke Impact Scale (SIS) and change in stroke severity (National Institutes of Health Stroke Scale; NIHSS) at 6 months. The secondary outcome was change in cognitive performance from baseline to 6-month follow-up. The relationship between scores from the two cognitive screens at follow-up was also explored. Results: A total of 821 patients from 37 different hospital or rehabilitation sites (England, UK) were recruited to the OCS-CARE study, with 467 completing 6-month follow-up. Patient outcomes defined by overall SIS scores and changes in NIHSS did not differ between the OCS or MoCA groups. There were high accordance rates between the OCS and MoCA at 6 months, with severity of cognitive impairment reflected in both screening tools. Cognitive performance in both groups over the 6-month follow-up declined in 22% of patients. A larger proportion of OCS group patients demonstrated improvements in cognitive scores (49% vs 40% in MoCA). Conclusions: The type of cognitive screening test did not impact broad stroke outcome measures, and the two screening tools showed a high overall accordance. The results suggest that more of the domain-specific deficits in OCS recover subacutely, providing a more granular picture of cognitive recovery as well as decline. Registration: ISRCTN50857950; registered on 27/03/2014.
Scaled deployment of Wolbachia to protect the community from dengue and other Aedes transmitted arboviruses
Authors: O'Neill Scott L. , Ryan Peter A. , Turley Andrew P. , Wilson Geoff , Retzki Kate , Iturbe-Ormaetxe Inaki , Dong Yi , Kenny Nichola , Paton Christopher J. , Ritchie Scott A. , Brown-Kenyon Jack , Stanford Darren , Wittmeier Natalie , Jewell Nicholas P. , Tanamas Stephanie K. , Anders Katherine L. , Simmons Cameron P. 
Published: August 2019

Background: A number of new technologies are under development for the control of mosquito transmitted viruses, such as dengue, chikungunya and Zika that all require the release of modified mosquitoes into the environment. None of these technologies has been able to demonstrate evidence that they can be implemented at a scale beyond small pilots. Here we report the first successful citywide scaled deployment of Wolbachia in the northern Australian city of Townsville. Methods: The wMel strain of Wolbachia was backcrossed into a local Aedes aegypti genotype and mass reared mosquitoes were deployed as eggs using mosquito release containers (MRCs). In initial stages these releases were undertaken by program staff but in later stages this was replaced by direct community release including the development of a school program that saw children undertake releases. Mosquito monitoring was undertaken with Biogents Sentinel (BGS) traps and individual mosquitoes were screened for the presence of Wolbachia with a Taqman qPCR or LAMP diagnostic assay. Dengue case notifications from Queensland Health Communicable Disease Branch were used to track dengue cases in the city before and after release. Results: Wolbachia was successfully established into local Ae. aegypti mosquitoes across 66 km2 in four stages over 28 months with full community support. A feature of the program was the development of a scaled approach to community engagement. Wolbachia frequencies have remained stable since deployment and to date no local dengue transmission has been confirmed in any area of Townsville after Wolbachia has established, despite local transmission events every year for the prior 13 years and an epidemiological context of increasing imported cases. Conclusion: Deployment of Wolbachia into Ae. aegypti populations can be readily scaled to areas of ~60km2 quickly and cost effectively and appears in this context to be effective at stopping local dengue transmission
Capturing data for emergency department performance monitoring purposes
Authors: McCabe Aileen , Brenner Maria , Larkin Philip , Nic An Fhailí Sinéad , Gannon Brenda , O'Sullivan Ronan , Wakai Abel 
Published: August 2019

Background: Good-quality data is required for valid and reliable key performance indicators. Little is known of the facilitators and barriers of capturing the required data for emergency department key performance indicators. This study aimed to explore and understand how current emergency department data collection systems relevant to emergency department key performance indicators are integrated into routine service delivery, and to identify the resources required to capture these data elements. Methods: Following pilot testing, we conducted two focus groups with a multi-disciplinary panel of 14 emergency department stakeholders drawn from urban and rural emergency departments, respectively. Focus groups were analyzed using Attride–Stirling’s framework for thematic network analysis. Results: The global theme “Understanding facilitators and barriers for emergency department data collection systems” emerged from three organizing themes: “understanding current emergency department data collection systems”; “achieving the ideal emergency department data capture system for the implementation of emergency department key performance indicators”; and “emergency department data capture systems for performance monitoring purposes within the wider context”. Conclusion: The pathways to improving emergency department data capture systems for emergency department key performance indicators include upgrading emergency department information systems and investment in hardware technology and data managers. Educating stakeholders outside the emergency department regarding the importance of emergency department key performance indicators as hospital-wide performance indicators underpins the successful implementation of valid and reliable emergency department key performance indicators.
Galleria mellonella insektua eta Caenorhabditis elegans nematodoa, infekzio eredu boteretsuak Candida glabrata eta erlazionatutako espezieen birulentzia ikertzeko
Authors: Hernando-Ortiz Ainara , Mateo Estibaliz , Ortega-Riveros Marcelo , De-la-Pinta Iker , Quindós Guillermo , Eraso Elena 
Published: August 2019

Kandidiasia Candida generoko espezieek eragindako infekzio mikotikoa da. Candida albicans agente etiologiko nagusia da baina gero eta gehiagotan Candida generoko beste espezie batzuk agertzen ari dira kandidiasiaren eragile bezala eta, hauen artean, Candida glabrata espeziea. Espezie honekin lotuta beste bi espezie daude, Candida bracarensis eta Candida nivariensis, teknika molekularrek ondo desberdindu ditzaketenak. Aldaketa etiologiko hauek ondorio larriak izan ditzakete kandidiasiaren diagnostikoan, tratamenduan edota pronostikoan, besteak beste, bere patogenia edo antifungikoekiko sentikortasuna oso desberdina izan daitezkeelako. Ordezko eredu esperimentalek erabiliz mikroorganismoek eragindako gaixotasunen patogenia eta terapia ezagutzeko ezinbesteko aukera ematen dizkigute, eta hauen artean, Caenorhabditis elegans nematodoa eta Galleria mellonella lepidopteroa ditugu. Ikerketa lan honetan konbentzionalak ez diren bi animalia eredu hauen erabilgarritasuna ebaluatu nahi izan da Candida glabrata, Candida bracarensis eta Candida nivariensis harreman filogenetiko estua duten hiru espezie hauen birulentzia in vivo aztertzeko.
La irrupción de la política en la escuela secundaria: nuevas figuras de ciudadanía
Authors: Núñez Pedro 
Published: August 2019

En este artículo se presenta un análisis de la construcción de ciudadanía en la escuela secundaria argentina. Se aborda la discusión sobre movimientos sociales y se presentan las características del sistema educativo. Luego, se indaga en las demandas y los repertorios de acción del movimiento estudiantil secundario. Finalmente, presentamos tres figuras de ciudadanía emergentes. Se concluye que existe un desplazamientoen las acciones políticas juveniles hacia la preeminencia de la toma de escuelas y una heterogeneidad de formas de participación con énfasis en los estilos juveniles.
Explorando «la grieta». Representaciones de la conflictividad social en miembros de la pequeña burguesía urbana
Authors: Artese Matías , Castro Rubel Jorge , Tapia Hernán 
Published: August 2019

En este artículo se exploran las nociones existentes sobre conflictividad y divisiones sociales en la Argentina actual, sus causas y consecuencias. Mediante la realización de entrevistas, dichas nociones se trabajaron con 13 pequeños empresarios de la región metropolitana de Buenos Aires. El objetivo es conocer los elementos que dan forma al concepto de «grieta», el cual forma parte de la agenda pública actual, impulsada a través de los medios de comunicación hegemónicos. Intentamos elucidar así un conocimiento que en principio se nos presenta fragmentario y contradictorio.
A study case for the analysis of asymptotic expansions beyond the tQSSA for inhibitory mechanisms in enzyme kinetics.
Authors: Bersani A. M. , Borri A. , Milanesi A. , Tomassetti G. , Vellucci P. 
Published: August 2019

AbstractIn this paper we study the model of the chemical reaction of fully competitive inhibition and determine the appropriate parameter∊(related to the chemical constants of the model), for the application of singular perturbation techniques. We determine the inner and the outer solutions up to the first perturbation order and the uniform expansions. Some numerical results are discussed.