bluuebunny/crossref_metadata_2025_split huggingface dataset:
Transcriptomic analysis of left-right differences in human embryonic forebrain and midbrain
Authors: de Kovel Carolien G. F. , Lisgo Steven N. , Francks Clyde 
Published: September 2018

AbstractLeft-right asymmetry is subtle but pervasive in the human central nervous system. This asymmetry is initiated early during development, but its mechanisms are poorly known. Forebrains and midbrains were dissected from six human embryos at Carnegie stages 15 or 16, one of which was female. The structures were divided into left and right sides, and RNA was isolated. RNA was sequenced with 100 base-pair paired ends using Illumina Hiseq 4000. After quality control, five paired brain sides were available for midbrain and forebrain. A paired analysis between left- and right sides of a given brain structure across the embryos identified left-right differences. The dataset, consisting of Fastq files and a read count table, can be further used to study early development of the human brain.
The Hydra I cluster core
Authors: Hilker M. , Richtler T. , Barbosa C. E. , Arnaboldi M. , Coccato L. , Mendes de Oliveira C. 
Published: September 2018

Context. NGC 3311, the central galaxy of the Hydra I cluster, shows signatures of recent infall of satellite galaxies from the cluster environment. Previous work has shown that the line-of-sight velocity dispersion of the stars and globular clusters in the extended halo of NGC 3311 rises up to the value of the cluster velocity dispersion. In the context of Jeans models, a massive dark halo with a large core is needed to explain this finding. However, position dependent long-slit measurements show that the kinematics are still not understood.
Aims. We aim to find kinematic signatures of sub-structures in the extended halo of NGC 3311.
Methods. We performed multi-object spectroscopic observations of the diffuse stellar halo of NGC 3311 using VLT/FORS2 in MXU mode to mimic a coarse “IFU”. The slits of the outermost masks reach out to about 35 kpc of galactocentric distance. We use PPXF to extract the kinematic information of velocities, velocity dispersions and the high-order moments h3 and h4.
Results. We find a homogeneous velocity field and velocity dispersion field within a radius of about 10 kpc. Beyond this radius, both the velocities and the velocity dispersion start to depend on azimuth angle and show a significant intrinsic scatter. The inner spheroid of NGC 3311 can be described as a slow rotator. Outside 10 kpc the cumulative angular momentum is rising, however, without showing an ordered rotation signal. If the radial dependence alone is considered, the velocity dispersion does not simply rise but fills an increasingly large range of dispersion values with two well defined envelopes. The lower envelope is about constant at 200 km s−1. The upper envelope rises smoothly, joining the velocity dispersion of the outer globular clusters and the cluster galaxies. We interpret this behaviour as the superposition of tracer populations with increasingly shallower radial distributions between the extremes of the inner stellar populations and the cluster galaxies. Simple Jeans models illustrate that a range of mass profiles can account for all observed velocity dispersions, including radial MOND models.
Conclusions. The rising velocity dispersion of NGC 3311 apparently is a result of averaging over a range of velocity dispersions related to different tracer populations in the sense of different density profiles and anisotropies. Jeans models using one tracer population with a unique density profile are not able to explain the large range of the observed kinematics. Previous claims about the cored dark halo of NGC 3311 are therefore probably not valid. This may in general apply to central cluster galaxies with rising velocity dispersion profiles, where infall processes are important.
Planetary tidal interactions and the rotational evolution of low-mass stars
Authors: Gallet F. , Bolmont E. , Bouvier J. , Mathis S. , Charbonnel C. 
Published: September 2018

Context. The surface angular velocity evolution of low-mass stars is now globally understood and the main physical mechanisms involved in it are observationally quite constrained. However, while the general behaviour of these mechanisms is grasped, their theoretical description is still under ongoing work. This is the case, for instance, about the description of the physical process that extracts angular momentum from the radiative core, which could be described by several theoretical candidates. Additionally, recent observations showed anomalies in the rotation period distribution of open cluster, main sequence, early K-type stars that cannot be reproduced by current angular momentum evolution models.
Aims. In this work, we study the parameter space of star-planet system’s configurations to investigate if including the tidal star-planet interaction in angular momentum evolution models could reproduce the anomalies of this rotation period distribution.
Methods. To study this effect, we use a parametric angular momentum evolution model that allows for core-envelope decoupling and angular momentum extraction by magnetized stellar wind that we coupled to an orbital evolution code where we take into account the torque due to the tides raised on the star by the planet. We explore different stellar and planetary configurations (stellar mass from 0.5 to 1.0 M⊙ and planetary mass from 10 M⊕ to 13 Mjup) to study their effect on the planetary orbital and stellar rotational evolution.
Results. The stellar angular momentum is the most impacted by the star-planet interaction when the planet is engulfed during the early main sequence phase. Thus, if a close-in Jupiter-mass planet is initially located at around 50% of the stellar corotation radius, a kink in the rotational period distribution opens around late and early K-type stars during the early main sequence phase.
Conclusions. Tidal star-planet interactions can create a kink in the rotation period distribution of low-mass stars, which could possibly account for unexpected scatter seen in the rotational period distribution of young stellar clusters.
Arabinogalaktan-Proteine (AGPs) aus dem kurzzeiterhitzten Presssaft von Echinacea purpurea
Authors: Classen Birgit 
Published: September 2018

ZusammenfassungPresssäfte der oberirdischen Teile von Echinacea purpurea (L.) Moench werden als unspezifische Immunstimulanzien eingesetzt. Als potenzielle Wirkstoffe werden hoch molekulare Polysaccharide bzw. Glykoproteine, insbesondere Arabinogalaktan-Proteine (AGPs), diskutiert. Aus dem kurzzeiterhitzten Presssaft von Echinacea purpurea wurde daher eine hochmolekulare Arabinogalaktan-Protein-Fraktion durch spezifische Fällung mit Yariv‘s Reagenz isoliert und charakterisiert. Es konnte gezeigt werden, dass die Hauptstrukturelemente des Polysaccharidanteils der AGPs denen des unbehandelten Presssaftes entsprechen und dass der AGP-Gehalt im Vergleich zu Ethanol-stabilisierten Presssäften um ein Vielfaches erhöht ist. Für Arabinogalaktan-Proteine aus den oberirdischen Teilen des Roten Sonnenhuts konnten in vitro bereits verschiedene immunmodulierende Aktivitäten nachgewiesen werden.
Ein Spital für Traditionelle Thailändische Medizin
Authors: Burri Josef 
Published: September 2018

ZusammenfassungTraditionelle Thailändische Medizin (TTM) fließt ins Behandlungsangebot der Krankenhäuser ein. Neben dem Ausbau von Lehre und Forschung und ergänzend zur weit verbreiteten Anwendung von TTM im Alltag der Thai hält das überlieferte und weiterentwickelte lokale Heilwissen auch Einzug in die Spitäler. Federführend bei diesem Prozess war ein Provinzspital, das den unaussprechlichen Namen Abhaibhubejhr-Hospital trägt. Es spielte auch eine Pionierrolle bei der Forschung und Konfektionierung von phytotherapeutischen Zubereitungen.
The Protective Effect of Heparin in a Dog Model of Rethrombosis Following Pharmacologic Thrombolysis
Authors: Voytik Sherry , Badylak Stephen F , Burke Sandra , Klabunde Richard E , Henkin Jack , Simmons Abby 
Published: September 2018

SummaryRethrombosis is an important clinical problem for patients who have benefitted from pharmacologic thrombolysis. The present study describes a dog model of arterial thrombosis, which includes endothelial denudation, intimal damage, and stenosis, and is suitable for studying the phenomena of both thrombolysis and subsequent rethrombosis. The model was used to determine the effect of tissue-type plasminogen activator (t-PA), high and low dose heparin, and saline upon the incidence of rethrombosis after t-PA-induced thrombolysis. Initial thrombolysis with reflow was achieved with 0.4 mg/kg t-PA, intravenous bolus injection, followed immediately by 0.4 mg/kg t-PA, 30 min infusion, in 40 of 42 dogs (95%) that had an occlusive, 125I-labelled thrombus created in a segment of femoral artery. The 40 dogs in which reperfusion was achieved were randomly sorted into 4 groups of 10 each which then received either saline, t-PA (0.4 mg kg−1 infused over 1 h), low dose heparin (500 U bolus injection then 250 U h−1 for 24 h), or high dose heparin (1,500 U bolus injection then 500 U h−1 for 24 h). Sixty percent (6/10) of the saline treated dogs showed occlusive rethrombosis at 24 h. The incidence of occlusive rethrombosis was 9/10 in the t-PA treated group (p = NS), 3/10 in the lowdose heparin treated group (p = NS), and 0/10 in the high dose heparin treated group (p <0.01). Two smaller groups consisting of 5 dogs each were treated with either saline or high dose heparinalone (no t-PA). None of the dogs in either group showed thrombolysis with reflow. All of the high dose heparin treated dogs and half of the low dose heparin treated dogs had prolonged values for the prothrombin time, activated partial thromboplastin time, and thrombintime through 24 h. All dogs treated with t-PA followed by additional t-PA had transient prolongations of the coagulation test values and also had a decrease in the plasma α2-antiplasmin concentration. These results suggest that heparin, when givenin high enough doses to cause risk of hemorrhage, provides protection against arterial rethrombosis following t-PA induced thrombolysis in a dog model of this clinically relevant problem.
Recurrent Chronic Subdural Hematoma: Clinical and Imaging Risk Factors
Authors: Abdennebi Benaissa , Al Shamiri Maher 
Published: September 2018

Abstract
Background Chronic subdural hematoma (CSDH) is a major cause of neurosurgical emergencies in the elderly. Despite the use of routine surgical practices, recurrence of this condition is expected. This study was conducted to identify the risk factors (RF) for recurrent CSDH.
Methods Between January 2016 and July 2017, 103 consecutive patients suffering from CSDH were admitted to our department. The no-recurrence group (NRG) consisted of 91 patients, and the recurrence group (RG) consisted of 12 patients. To identify the RF involved in recurrent CSDH, we analyzed multiple factors, including patient comorbidities and imaging data.
Results Between the two groups, there were no statistical differences (p > 0.05) for head trauma, diabetes mellitus (DM), high blood pressure, heart diseases, anticoagulation agents, or seizures; however, DM was associated with one of the above-mentioned factors. In contrast, there were significant differences for antiplatelet agents (APA) (p < 10–6) and the right side of the hematoma location (p = 0.03).
Conclusion Although the literature highlights the controversy regarding RF for CSDH, we detected APA and the right side as RF, whereas DM alone or associated with another comorbidity does not affect the CSDH outcome.
Dexmedetomidine for Sedation of Neonates with HIE Undergoing Therapeutic Hypothermia: A Single-Center Experience
Authors: O'Mara Keliana , Weiss Michael 
Published: September 2018

AbstractHypoxic-ischemic encephalopathy (HIE) is a significant cause of morbidity and mortality in neonates. Therapeutic hypothermia reduces the risk of death or disability. Providing optimal sedation while neonates are undergoing therapeutic hypothermia is likely beneficial but may present therapeutic challenges. There are limited data describing the use of dexmedetomidine for sedation in patients undergoing therapeutic hypothermia. The objective of this study is to evaluate the efficacy and short-term safety of dexmedetomidine infusion for sedation in term neonates undergoing therapeutic hypothermia for HIE.
Inhibition of cIAP1 as a strategy for targeting c-MYC–driven oncogenic activity
Authors: Li Haoyan , Fang Yanjia , Niu Chunyi , Cao Hengyi , Mi Ting , Zhu Hong , Yuan Junying , Zhu Jidong 
Published: September 2018

Significance
Dysregulated expression of master transcription factor c-MYC has been shown to promote proliferation and cell survival programs in cancer cells to mediate resistance to anticancer therapies and promote metastasis. Development of pharmacological agents to inhibit c-MYC as an anticancer therapy is a longstanding but elusive goal in the cancer field. Our study provides a potential widely applicable pharmacological strategy for targeting c-MYC–driven oncogenic activity by inhibiting cIAP1 E3 ubiquitin ligase activity as a treatment for cancers. Furthermore, we demonstrate the pharmacological interference in the dynamic interaction of an E3 ubiquitin ligase with its E2s as a strategy for inhibiting ubiquitination reactions.
VarSelLCM: an R/C++ package for variable selection in model-based clustering of mixed-data with missing values
Authors: Marbac Matthieu , Sedki Mohammed 
Published: September 2018

AbstractSummaryVarSelLCM allows a full model selection (detection of the relevant features for clustering and selection of the number of clusters) in model-based clustering, according to classical information criteria. Data to be analyzed can be composed of continuous, integer and/or categorical features. Moreover, missing values are managed, without any pre-processing, by the model used to cluster with the assumption that values are missing completely at random. Thus, VarSelLCM also allows data imputation by using mixture models. A Shiny application is implemented to easily interpret the clustering results.Availability and implementationVarSelLCM is available to download at https://CRAN.R-project.org/package=VarSelLCM/.Tutorialvignette is available online at http://varsellcm.r-forge.r-project.org/Supplementary informationSupplementary data are available at Bioinformatics online.
Acute kidney injury associated with lymphangitic carcinomatosis
Authors: Sannier Aurélie , Dupuis Emmanuel , Berger Anne Katrin , Bischofs Christian , Massy Ziad A , Seidowsky Alexandre 
Published: September 2018

Abstract
Acute kidney injury (AKI) is a major complication in patients with cancer, associated with significant morbidity and mortality. Only two cases of kidney lymphangitic carcinomatosis associated with AKI have been reported, in gastric and colorectal adenocarcinoma. Here, we report on a 53-year-old man with pancreatic adenocarcinoma who developed AKI as a result of kidney lymphangitic carcinomatosis. The patient rapidly became anuric and required haemodialysis. Kidney lymphangitic carcinomatosis should be considered as a cause of AKI in patients with cancer and may become a more frequent clinical finding as patients with metastatic carcinoma survive for longer.
Appendectomy for Therapy-Refractory Ulcerative Colitis Results in Pathological Improvement of Colonic Inflammation: Short-Term Results of the PASSION Study
Authors: Sahami S , Wildenberg M E , Koens L , Doherty G , Martin S , D’Haens G R A M , Cullen G , Bemelman W A , Winter D , Buskens C J 
Published: September 2018

Abstract

Background and Aims
The objective of this study was to examine the modulating effect of an appendectomy on the disease course of therapy-refractory ulcerative colitis [UC] patients, and to analyse appendiceal pathological characteristics predictive of pathological response.

Methods
Patients with therapy-refractory UC, and referred for proctocolectomy, were invited to undergo laparoscopic appendectomy first. The primary end points were clinical response after 3 and 12 months. Secondary end points were endoscopic remission, failure, and pathologic response. Appendiceal specimens, and pre- and post-operative biopsies were histologically graded according to the validated Geboes score.

Results
Thirty patients [53% male] with a median age of 40 (interquartile range [IQR], 33–47) underwent appendectomy, with a median preoperative total Mayo score of 9 [IQR, 8–11]. After 12 months, 9 patients [30%] had lasting clinical response, of whom 5 [17%] were in endoscopic remission. Pathological evaluation was possible in 28 patients. After a median of 13.0 weeks [range 7–51], pathological response was seen in 13 patients [46%], with a median decrease of 2 points [range 1–3]. Appendiceal inflammation was highly predictive of pathological response when compared with no inflammation or extensive ulcerations [85% vs 20%, p = 0.001].

Conclusions
Appendectomy was effective in one-third of therapy-refractory UC patients, with a substantial proportion of patients demonstrating complete endoscopic remission after 1 year. Pathological response was seen in almost 50% of patients and was related to active inflammation in the appendix, limited disease, and shorter disease duration. These early results suggest that there is a UC patient group that may benefit from appendectomy.
Aortic stenosis exacerbates flow aberrations related to the bicuspid aortic valve fusion pattern and the aortopathy phenotype
Authors: Shan Yan , Li Jun , Wang Yongshi , Wu Boting , Barker Alex J , Markl Michael , Wang Chunsheng , Wang Xiaolin , Shu Xianhong 
Published: September 2018

Abstract

OBJECTIVES
A bicuspid aortic valve (BAV) is characterized by variable phenotypic manifestations, as well as longitudinal evolution of valve dysfunction and ascending aorta dilatation. The present study investigated the impact of severe aortic stenosis (AS) on the flow patterns and wall shear stress (WSS) distribution in BAV patients with right–left (RL) and right-non-coronary (RN) cusp fusion types, and the study aimed to reveal whether aortic dysfunction could further alter intrinsic aortic haemodynamic aberrations generated by abnormal BAV cusp fusion patterns.

METHODS
Four-dimensional flow magnetic resonance imaging was performed in 120 BAV subjects and 20 tricuspid aortic valve controls. BAV patients were evenly categorized into 4 cohorts, including RL and RN BAV with no more than mild aortic dysfunction as well as RL and RN BAV-AS with isolated severe AS.

RESULTS
BAV subjects exhibited eccentric outflow jets resulting in regional WSS elevation at the right-anterior position of the ascending aorta in the RL group and the right-posterior location in the RN group (P < 0.005). The presence of severe AS resulted in accelerated outflow jets and more prominent flow and WSS eccentricity (P < 0.005) by marked helical (P = 0.014) and vortical flow formation (P < 0.005), as well as increased prevalence of tubular and transverse arch dilatation. The changes to the flow jet in BAV-AS subjects blurred the differences in peak flow velocity and WSS distribution between RL and RN BAV. Differences in the phenotypes of aortopathy were associated with changes in functional haemodynamic parameters such as flow displacement and WSS eccentricity.

CONCLUSIONS
Severe AS markedly exacerbated aortic flow aberrations in BAV patients and masked the existing distinct flow features deriving from RL and RN fusion types. Longitudinal studies are needed to investigate the evolution of ascending aortic dilatation relative to the interaction between intrinsic cusp fusion types and acquired severe valve dysfunction.
Generalized notions of sparsity and restricted isometry property. Part I: a unified framework
Authors: Junge Marius , Lee Kiryung 
Published: September 2018

AbstractThe restricted isometry property (RIP) is an integral tool in the analysis of various inverse problems with sparsity models. Motivated by the applications of compressed sensing and dimensionality reduction of low-rank tensors, we propose generalized notions of sparsity and provide a unified framework for the corresponding RIP, in particular when combined with isotropic group actions. Our results extend an approach by Rudelson and Vershynin to a much broader context including commutative and non-commutative function spaces. Moreover, our Banach space notion of sparsity applies to affine group actions. The generalized approach in particular applies to high-order tensor products.
Acute Abdomen in Pediatric Patients With Lassa Fever: Prevalence and Response to Nonoperative Management
Authors: Akpede George O , Adetunji Adewale E , Udefiagbon Ernest O , Eluehike Sylvester O , Odike Angela I , Ewah-Odiase Rosemary O , Omosofe Folorunso O , Akerele Johnbull M , Atafo Rebecca O , Okonofua Martha O , Onyeke Imonifome , Oyedeji Omobolaji A , Mbanefo Kaine , Ogbaini-Emovon Ephraim , Okokhere Peter O , Günther Stephan , Dongo Andrew E 
Published: September 2018

Abstract
Few reports on the prevalence of acute abdomen (AAbd) in pediatric patients with Lassa fever (LF) are available, and no firm policy on its management exists. Here, we report on its prevalence in and the response to treatment among a cohort of children with confirmed LF. Six (10.3%) of 58 children with LF had AAbd, whereas 6 (2.8%) of 215 children with AAbd had LF. Nonoperative treatment was successful in 5 of the 6 children with both AAbd and LF. We conclude that AAbd is not uncommon in pediatric patients with LF, and it could be responsive to nonoperative treatment. Testing for LF in all children with febrile AAbd might be justified in areas in which LF is endemic.
Resources, Values, Identity: Young Cosmopolitans and the Referendum on British Membership of the European Union
Authors: Ehsan Rakib , Sloam James 
Published: September 2018

AbstractIn the aftermath of the global financial crisis, we have witnessed a resurgence in nationalism, Euroscepticism and populist politics in Europe and the United States. Young people have borne the brunt of this crisis. Yet, in the 2016 UK referendum, the vast majority of younger citizens voted for Britain to remain in the European Union. But why did they do so? Drawing upon a bespoke survey of 1351 18- to 30-year-olds, this article investigates the relative importance of socio-demographic factors, post-materialist values and primary self-identification. It finds that positive views about cultural diversity and being a full-time student were the greatest predictors of a young person voting Remain, whilst no significant association is found between higher educational attainment and voting Remain at the multivariate level. Setting the EU referendum within the broader context of youth politics, the article also identifies the existence of cosmopolitan values amongst young Remainers. This has major implications for both our understanding of the success of Jeremy Corbyn and the Labour Party amongst young voters in the 2017 general election, and the challenges the Conservative Party faces with regard to establishing support among Britain’s young cosmopolitans for future elections.