bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hypomagnesemia and Survival in Patients with Ovarian Cancer Who Received Chemotherapy with Carboplatin
Authors: Liu Wenli , Qdaisat Aiham , Soliman Pamela T. , Ramondetta Lois , Lopez Gabriel , Narayanan Santhosshi , Zhou Shouhao , Cohen Lorenzo , Bruera Eduardo , Yeung Sai-Ching J. 
Published: April 2019

Abstract

Background
Hypomagnesemia is a known side effect of several antineoplastic agents, but its impact on outcomes of patients with cancer is not well understood. We examined whether magnesium abnormalities affect survival in patients with ovarian cancer who receive chemotherapy containing carboplatin.

Materials and Methods
We included patients with advanced ovarian cancer who had undergone surgery and chemotherapy between January 1, 2004, and December 31, 2014, at our institution. Inclusion criteria were age 18 years or older, pathology of high-grade serous carcinoma, first treatment (surgery or chemotherapy) within 60 days of diagnosis, and chemotherapy containing carboplatin. The final cohort consisted of 229 patients. Vital signs and laboratory tests were recorded at baseline and during the treatment course. The associations between magnesium abnormalities (and other clinical characteristics) and survival were analyzed.

Results
The median patient age was 64 years. Higher baseline heart rate (beats per minute; hazard ratio [HR] = 1.02, p = .002) and greater frequency of hypomagnesemia during the treatment course (HR = 1.05, p = .002) were significantly associated with shorter survival independent of completeness of tumor reduction (HR = 1.60, p = .02), and International Federation of Gynecology and Obstetrics stage (HR = 1.63, p = .01).

Conclusion
Baseline heart rate and the frequency of hypomagnesemia episodes during treatment are prognostic of survival for patients with advanced ovarian cancer receiving carboplatin-containing chemotherapy and tumor reductive surgery. Future research is needed for strategies to detect and prevent hypomagnesemia in this patient population.
Lenalidomide in Pretreated Patients with Diffuse Large B-Cell Lymphoma: An Italian Observational Multicenter Retrospective Study in Daily Clinical Practice
Authors: Broccoli Alessandro , Casadei Beatrice , Chiappella Annalisa , Visco Carlo , Tani Monica , Cascavilla Nicola , Conconi Annarita , Balzarotti Monica , Cox Maria Christina , Marino Dario , Goldaniga Maria Cecilia , Marasca Roberto , Tecchio Cristina , Patti Caterina , Musuraca Gerardo , Devizzi Liliana , Monaco Federico , Romano Alessandra , Fama Angelo , Zancanella Michelle , Paolini Rossella , Rigacci Luigi , Castellino Claudia , Gaudio Francesco , Argnani Lisa , Zinzani Pier Luigi 
Published: April 2019

Abstract

Background
Diffuse large B-cell lymphoma (DLBCL) is the most common non-Hodgkin lymphoma subtype, and approximately 50% of the patients are &gt;60 years of age. Patients with relapsed/refractory (rr) disease have a poor prognosis with currently available treatments. Lenalidomide is available in Italy for patients with rrDLBCL based on a local disposition of the Italian Drug Agency.

Subjects, Materials, and Methods
An observational retrospective study was conducted in 24 Italian hematology centers with the aim to improve information on effectiveness and safety of lenalidomide use for rrDLBCL in real practice.

Results
One hundred fifty-three patients received lenalidomide for 21/28 days with a median of four cycles. At the end of therapy, there were 36 complete responses (23.5%) and 9 partial responses with an overall response rate (ORR) of 29.4%. In the elderly (&gt;65 years) subset, the ORR was 33.6%. With a median follow-up of 36 months, median overall survival was reached at 12 months and median disease-free survival was not reached at 62 months. At the latest available follow-up, 29 patients are still in response out of therapy. Median progression-free survivals differ significantly according to age (2.5 months vs. 9.5 in the younger vs. elderly group, respectively) and to disease status at the latest previous therapy (15 months for relapsed patients vs. 3.5 for refractory subjects). Toxicities were manageable, even if 30 of them led to an early drug discontinuation.

Conclusion
Lenalidomide therapy for patients with rrDLBCL is effective and tolerable even in a real-life context, especially for elderly patients.

Implications for Practice
Diffuse large B-cell lymphoma (DLBCL) is the most common subtype of non-Hodgkin lymphoma, and approximately 50% of the patients are &gt;60 years of age. Patients with relapsed/refractory (rr) disease have a poor prognosis, reflected by the remarkably short life expectancy of 12 months with currently available treatments. The rrDLBCL therapeutic algorithm is not so well established because data in the everyday clinical practice are still poor. Lenalidomide for patients with rrDLBCL is effective and tolerable even in a real-life context, especially for elderly patients.
EUS-assisted biliodigestive anastomoses for malignant mechanical jaundice
Authors: Rudakova M. N. , Ryabov K. Yu. , Zhevelyuk A. G. , Trandofilov M. M. , Prokhorov A. V. , Popov A. Yu. 
Published: April 2019

Aim. To assess the role of endoscopic ultrasonography (EUS) in bile duct drainage for malignant mechanical jaundice followed by abnormal anatomy of upper gastrointestinal tract.Material and methods. There were 43 attempts to form EUS-assisted biliodigestive anastomoses in 43 patients for the period 2014–2018. Procedure was successful in 33 (76.74%) patients.Results. Two periods were identified to analyze the results. The first period (2014–2015) included 21 patients who underwent surgery, the second period (2016–2018) – 22 patients. In the first period, the effectiveness of EUS-assisted procedures was 57%, in the second one – 96%.Conclusion. EUS-assisted biliodigestive anastomoses are useful for biliary decompression in various anatomical situations including switching off the duodenum from food passage. These operation is safe alternative to other types of decompression with accumulation of experience.
The results of endosonography-assisted internal drainage of pancreatic pseudocyst
Authors: Starkov Yu. G. , Zamolodchikov R. D. , Dzhantukhanova S. V. , Vyborniy M. I. , Lukich K. V. , Ibragimov A. S. , Goncharov I. M. , Lavrentyeva V. Yu. 
Published: April 2019

Aim.To compare immediate and long-term results of internal drainage of pancreatic pseudocyst by using of endosonography-assisted and open surgical approaches.Material and methods.EUS-assisted internal drainage of pancreatic pseudocyst was performed in 32 patients in 2011–2016. Open drainage procedures were carried out on the other 32 patients.Results.In the group of endoscopic drainage, technical success rate, clinical success rate and complication rate were 97%, 85% and 26%, respectively. There were no recurrent pseudocysts in long-term period. Comparison with open surgery confirmed advantages of endoscopic technique regarding time of operation (p< 0.01), intraoperative blood loss (p< 0.01) and length of hospital-stay (p< 0.01).Conclusion.EUS-assisted internal drainage of pancreatic pseudocysts in the treatment of chronic pancreatitis is characterized by high rate of technical and clinical success, small postoperative morbidity and low incidence of longterm recurrences.
Bile duct injuries and systemic approach to the treatment
Authors: Romashchenko P. N. , Maystrenko N. A. , Pryadko A. S. , Aliev A. K. 
Published: April 2019

Aim.Present a program of examination and treatment of patients with biliary duct injury, corresponding to the level of the international protocol and modern requirements for the quality of medical care.Material and methods.The results of examination and treatment of 77 patients with bile ducts injuries are analyzed. The analysis of the main surgical interventions for the elimination of bile ducts injuries is given: reconstructive operations in 44.3% of patients, recovery operations – in 36.7% and external drainage – in 19%.Results.A program approach has been developed to assist patients with bile duct injuries in civil health care at various levels of surgical care.Conclusions.The implementation of this program provides timely diagnosis of damage to the bile duct and minimizing the number of postoperative complications at the second and third levels of surgical care. It was determined that a rational approach to reduce the number of injuries of the bile ducts is their prevention by perfect adherence to the technique of surgical intervention on the organs of the upper floor of the abdominal cavity, and to reduce the number of negative consequences, the proposed algorithm for diagnosis and treatment.
X-ray surgery for benign biliary strictures after cholecystectomy
Authors: Okhotnikov O. I. , Yakovleva M. V. , Gorbacheva O. S. 
Published: April 2019

Aim.To determine the role of antegrade X-ray surgical interventions in the treatment of benign postoperative biliary strictures.Material and methods.A retrospective analysis of treatment of 36 patients with benign biliary strictures was performed. Isolated stricture of biliodigestive anastomosis was diagnosed in 25 cases, partial clipping of common hepatic duct proximal to biliodigestive anastomosis – in 3 cases, partial clipping of bile duct – in 3 patients, isolated biliary strictures – in 5 patients including 4 of them with stricture within previously deployed T-shaped drainage. At the first stage, percutaneous transhepatic cholangiostomy was performed. According to antegrade cholangiography data, structure type “+1, +2” by H. Bismuth classification in modification of E. I. Galperin was diagnosed in 16 (55.2%) patients, proximal biliary strictures (“0”–“−2”) in 13 patients. Three patients with partial clipping of common bile duct and 4 patients with benign biliary stricture in the area of previously deployed T-shaped drainage were not classified. Recanalization of strictures by “catheter-guide” system was followed by antegrade dilatation of the stricture. Final stage was frame external-internal drainage for 6–12 months with stepwise redo balloon dilatation every 3 months (35 patients). The criterion for the end of minimally invasive treatment was the absence of balloon waist in the stricture zone observed during the next procedure but not earlier than in 6 months from primary balloon dilatation. Surgical correction was indicated for recurrent stricture.Results.Direct technical success was achieved in 35 patients. There was 1 case of recurrent strictures within 1 year among 3 cases of primary repair of biliary strictures in the area of previously installed T-shaped drainage. Resection of common bile duct stricture was followed by Roux-en-Y hepaticojejunostomy. Recurrence-free period among 36 patients ranged from 1 to 10 years, median – 56 months. There were no mortality and complications after X-ray surgery.Conclusion.Antegrade recanalization and balloon dilatation of the stricture followed by long-term external-internal biliodigestive frame drainage are effective for both stricture of biliodigestive anastomosis and partial clipping of bile duct. Conventional surgical procedures should be preferred for cicatricial strictures of extrahepatic bile ducts after previous T-shaped drainage deployment.
PISA 2003 ve 2012 Matematik Okuryazarlığı Puanlarının Ölçüt Geçerliği: Beklenti Tabloları ve Uyum Analizi
Authors: KILIÇ Abdullah Faruk , ERDEM-KARA Başak , DOĞAN Nuri 
Published: April 2019

Bu çalışmanın amacı PISA 2003 ve 2012 matematik okuryazarlığı
puanlarının ölçüt geçerliğini beklenti tabloları ve uyum analizi yardımıyla
araştırmaktır. Bu amaçla PISA 2003 ve 2012 problem çözme becerileri puanları
kullanılmıştır. Puanlar 3 farklı şekilde kategorize edilmiştir. İlk olarak PISA
tarafından kullanılan puan aralıkları kullanılmıştır. Ancak PISA puanlarını 357
ve altını da bir kategori kabul ederek 7 kategori oluşturulmuştur. Ayrıca puan
aralıkları %10 ve %20’lik dilimlere bölünerek beklenti tabloları oluşturulmuş,
damlacık grafikleriyle görsel olarak yorumlanması sağlanmış ayrıca kategoriler
arasındaki uyumu incelemek için uyum analizi yapılmıştır. Araştırma sonucunda
matematik puanlarının %20’lik dilimler halinde kategorize edildiğinde %10’luk dilimlere
göre daha uyumlu sonuçlar elde edildiği, beklenti tablolarında oranların
yükseldiği gözlenmiştir. PISA puan kategorisinde matematik puan kategorileriyle
problem çözme puanı kategorilerinin benzer olduğu söylenebilir.
Türkiye’de Tartışmalı ve Sosyobilimsel Konular Üzerine Yazılan Lisansüstü Tezlerin Eğitim Bilimleri Perspektifinden İncelenmesi
Authors: TATAR Şefika , ADIGÜZEL Oktay Cem 
Published: April 2019

Bu çalışma kapsamında, 2007-2016 yılları arasında
Türkiye’de tartışmalı ve sosyobilimsel konular üzerine gerçekleştirilen
tezlerin yüksek lisans ve doktora düzeylerine, yıllara ve anabilim/bilim
dallarına, konu alanlarına ve araştırma modellerine göre dağılımlarının
incelenmesi amaçlanmıştır. Betimsel tarama modelinde desenlenen bu çalışmada
tezler, araştırmacı tarafından hazırlanan bir betimsel analiz formu
doğrultusunda incelenmiştir. Yapılan analizler sonucunda tartışmalı ve
sosyobilimsel konuların ağırlıklı olarak ilköğretim ve yükseköğretim
düzeyindeki tezlerde araştırma konusu yapıldığı tespit edilmiştir. Tartışmalı
ve sosyobilimsel konular üzerine yapılan çalışmaların konu alanları
incelendiğinde çalışmaların yoğunluklu olarak fen ve biyoetik konularında
gerçekleştirildiği, bunların dışında kalan konularda çok sınırlı sayıda kaldığı
gözlenmiştir. Sosyobilimsel konuların bilişsel beceriler üzerindeki etkisi en
çok araştırılan konu olurken; bu konularla ilgili duyuşsal beceriler en çok
araştırılan ikinci konu olmuştur
Pengaruh Kecukupan Modal dan Risiko Kredit Terhadap Likuiditas Pada Bank Umum Syariah Yang Terdaftar di Bank Indonesia
Authors: Gautama Budhi Pamungkas , Annisa Rizka , Waspada Ikaputera 
Published: April 2019

AbstractThis research is based on the increasing number of liquidity of Islamic General Bank which is registered in Bank of Indonesia. The aim of this research is to find out the image of capital adequacy by using CAR indicator, credit risk by using NPF indicator and examine the impact of capital adequacy and credit risk towards the liquidity of islamic general bank which is registered in Bank of Indonesia. The research method used in this research is descriptive and verification method. This research used capital adequacy secondary data, credit risk and liquidity which are based on the financial statements from each bank which have been managed in 2012-2016 period. The analysis technique for this research was by using classical assumption test, regression analysis panel data and hypothesis test. This study used purposive sampling in islamic general bank registered in Bank of Indonesia in 2012-2016 period. This research was done by panel data analysis that was assisted by an application named Eview 8. Based on regression significance test, the capital adequacy and credit risk have influenced the liquidity itself. Based on the regression coefficient test, the capital adequacy gave significant positive effect to the liquidity, while the credit risk gave significant negative effect to liquidity. Keywords. capital adequacy; credit risk; liquidity AbstrakPenelitian ini dilatarbelakangi oleh meningkatnya likuiditas pada Bank Umum Syariah yang terdaftar di Bank Indonesia. Tujuan dari penelitian ini adalah untuk mengetahui gambaran kecukupan modal dengan menggunakan indikator CAR, risiko kredit dengan menggunakan indikator NPF dan likuiditas dengan menggunakan indikator FDR serta menguji pengaruh kecukupan modal dan risiko kredit terhadap likuiditas pada bank umum syariah yang terdaftar di Bank Indonesia. Metode penelitian yang dilakukan dalam penelitian ini yaitu dengan menggunakan metode deskriptif dan verifikatif. Data yang digunakan dalam penelitian ini adalah data sekunder kecukupan modal, risiko kredit dan likuiditas yang bersumber dari laporan keuangan dari masing-masing bank yang sudah diolah periode 2012-2016. Teknik analisis yang dilakukan dalam penelitian ini dengan menggunakan uji asumsi klasik, analisis regresi data panel dan uji hipotesis. Penelitian ini menggunakan teknik penelitian dengan cara purposive samplingpada bank umum syariah yang terdaftar di Bank Indonesia periode 2012-2016. Penelitian ini dilakukan menggunakan analisis data paneldengan dibantu oleh aplikasi Eviews 8. Berdasarkan uji keberartian regresi, kecukupan modal dan risiko kredit berpengaruh terhadap likuiditas. Berdasarkan uji koefisien regresi, kecukupan modal berpengaruh positif signifikan terhadap likuiditas, sedangkan risiko kredit berpengaruh negatif signifikan terhadap likuiditas. Kata kunci. kecukupan modal; risiko kredit; likuiditas
Analisis Penerapan Metode Activity Based Costing dalam Menentukan Harga Sewa Kamar Hotel
Authors: Faishal Fahmi Hikmah , Mulyani Heni , Yulianti Leni 
Published: April 2019

Abstract.This study aims to find out how the application of hotel room rental prices by using activity based costing at de’Kayakini Bandung hotels. This study uses descriptive research methods. Descriptive research to determine the difference in activity based costing methods with traditional methods. In this study there is only one type of variable used, namely rent. The rental price is the amount of money that will be paid for something to be received, the rental price in this study is the selling price. The data sources used in this study are secondary data sources. Secondary data is obtained from Hotel De’Kayakini in the form of hotel cost reports. The results of the study show that from the calculation of the cost of rooms using the activity based costing method, the lower cost of goods is obtained compared to the traditional cost accounting method.Keywords. activity based costing; room rental prices AbstrakPenelitian ini bertujuan untuk untuk mengetahui bagaimana penerapan harga sewa kamar hotel dengan menggunakan activity based costing pada hotel de’Kayakini Bandung. Penelitian ini menggunakan metode penelitian deskriptif. Penelitian deskriptif untuk mengetahui perbedaan metode activity based costing dengan metode tradisional. Dalam penelitian ini terdapat hanya satu jenis variabel yang digunakan yaitu harga sewa. Harga sewa adalah sejumlah uang yang akan dibayarkan untuk sesuatu hal yang akan diterima, harga sewa dalam penelitian ini adalah harga jual. Sumber data yang digunakan dalam penelitian ini, merupakan sumber data sekunder. Data sekunder didapatkan dari Hotel De’Kayakini berupa laporan biaya hotel. Hasil penelitian menunjukkan bahwa dari perhitungan harga pokok kamar dengan menggunakan metode activity based costing diperoleh harga pokok yang lebih rendah dibandingkan dengan metode traditional cost accounting.Kata kunci. activity based costing; harga sewa kamar
Pengaruh Leverage Keuangan Terhadap Profitabilitas Pada Perusahaan Sub-Sektor Telekomunikasi Yang Terdaftar Di Bursa Efek Indonesia
Authors: Christian Jogi , Supriyatna Yayat , Faruk Umar 
Published: April 2019

Abstract.This study aims to describe the financial leverage and profitability of the company and how the influence of financial leveraege on profitability in the telecommunications sub-sector companies listed on the Indonesia Stock Exchange. With survey research through descriptive and verification methods, the research sample was 4 telecommunications companies in the period 2007-2016. The sampling technique uses Purposive Sampling, while the analysis technique uses simple linear regression using the help of EViews software 9. Based on the descriptive analysis of financial leverage from year to year it tends to be relatively up and fluctuating profitability but is quite decreased compared to the initial year of the study. The effect of financial leverage on profitability is 56% while the remaining 44% is influenced by other factors, the results of hypothesis testing indicate that the effect of financial leverage on profitability has a significant negative effect so that the results of the study can be generalized to the population. Keywords. Financial Leverage; DAR; Profitability, ROA AbstrakPenelitian ini bertujuan untuk mengetahui gambaran leverage keuangan dan profitabilitas perusahaan serta bagaimana pengaruh leveraege keuangan terhadap profitabilitas pada perusahaan sub-sektor telekomunikasi yang terdaftar di Bursa Efek Indonesia. Dengan penelitian survey melalui metode deskriptif dan verifikatif, sampel penelitian adalah 4 perusahaan telekomunikasi pada periode 2007-2016. Teknik sampling menggunakan Purposive Sampling, sedangkan teknik analisis menggunakan regresi linier sederhana menggunakan bantuan software EViews 9. Berdasarkan analisis deskriptif leverage keuangan dari tahun ke tahun cenderung relatif naik dan profitabilitas fluktuatif namun cukup menurun jika dibandingkan dengan tahun awal penelitian. Pengaruh leverage keuangan terhadap profitabilitas sebesar 56% sementara sisanya 44% dipengaruhi oleh faktor lain, hasil uji hipotesis menunjukkan bahwa pengaruh leverage keuangan terhadap profitabilitas berpengaruh negatif signifikan sehingga hasil penelitian dapat digeneralisasikan kepada populasi. Kata Kunci. Leverage Keuangan, DAR, Profitabilitas, ROA
Pengaruh Pendapatan Garansi Bank Terhadap Laba Operasional
Authors: Sugiyanto Sugiyanto 
Published: April 2019

AbstractThis research was conducted to determine influence of the bank guarantee revenue to the operating profit at PT Bank BJB Tbk Cabang Utama Bandung Period from January to December 2015. This research used a quantitative method. Data collection techniques used observation and literature study. The writer used Pearson correlations analysis, determination and Regression. The result showed that the correlation between revenue of bank guarantee and operating profit at PT. Bank BJB Tbk Cabang Utama Bandung Period from January to December 2015 had a vey low relationship with level of correlation coefficient as much as 0,189. While the influence of guarantee bank to operating profit was found to be 0,36% and the remaining of 99,64% was influenced by other factors which were not observed by the writer. There were obstacles in this research, such as; incompleteness of supporting document, there was collectability of customers at the time of analysis BI – Checking, as well as the legality of the company that were not updated or a change of leadership. The suggestion for the company is to improve the publishing process faster, in order to increase customer’s confidence so that an application for a bank guarantee will be more and income on bank guarantee will be even greater.Keywords. bank guarante revenue; operating profit.Abstrak Penelitian ini dilakukan untuk mengetahui pengaruh pendapatan garansi bank terhadap laba operasional pada PT Bank BJB Tbk Cabang Utama Bandung Periode Januari - Desember 2015. Penelitian ini menggunakan metode penelitian kuantitatif, teknik pengumpulan data melalui wawancara, observasi, dan studi kepustakaan. Peneliti menggunakan analisis Pearson, determinasi, dan Regresi Sederhana. Hasil penelitian menunjukkan bahwa keterkaitan pendapatan garansi bank dan laba operasional pada PT Bank BJB Tbk Cabang Utama Bandung mempunyai tingkat hubungan sangat rendah dengan nilai koefisien korelasi sebesar 0,189. Sedangkan besar pengaruh pendapatan garansi bank terhadap laba operasional ditemukan sebesar 0,36% dan sisanya sebesar 99,64% dipengaruhi faktor lainnya yang tidak diteliti oleh penulis. Adapun kendala dalam penelitian ini yaitu ketidaklengkapan dokumen pendukung, terdapat kolektabilitas nasabah pada saat analisis BI – Checking serta legalitas perusahaan yang sudah tidak update atau ada perubahan kepemimpinan. Adapun saran untuk perusahaan yaitu sebaiknya meningkatkan proses penerbitan lebih cepat, agar kepercayaan nasabah meningkat sehingga permintaan untuk penetbitan garansi bank lebih banyak dan pendapatan atas penerbitan garansi bank akan semakin besar.Kata Kunci. laba operasional; pendapatan garansi bank.