bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical Analysis of Hospital-acquired Bloodstream Infection in the Elderly
Authors: Sun Baojun 
Published: May 2019

Objective: This study was designed to get epidemiological characteristics, etiology characteristics, prognosis assessment and prognostic factors of hospital-acquired bloodstream infection (HABSI) in the elderly in Chinese PLA General Hospital and aimed at providing a reference for HABSI in the elderly on clinical diagnosis and treatment to improve the prognosis. Methods: The clinical data and pathology data of 210 cases of the elderly patients with HABSI from 2009 to 2012 in geriatric wards were retrospectively analyzed. Compare the clinical assessment effects of APACHE-II score, SAPS-II score and SOFA score to HABSI prognosis in the elderly by plotting the receiver operating characteristic curve. Use univariate and multivariate logistic regression analysis to get prognostic factors of HABSI in the elderly. Results: Univariate analysis of mortality: Day 1 apache -> 18 II score, lung infection, invasive ventilation, chronic hepatic insufficiency, chronic renal insufficiency, substantive organ malignant tumor, deep venipuncture, indwelling gastric tube indwelling ureter, complicated with shock and acquired bloodstream infections in the elderly patients with 7 days survival state association is significant. Day-1 SOFA score>7, chronic liver dysfunction, chronic renal insufficiency, concurrent shock, hemodialysis and 28-day survival status of patients with acquired bloodstream infection in elderly hospitals were significantly associated. Multivariate unconditioned logistic regression analysis related to death: Day-1APACHE-II score>18, parenchymal malignant tumors, and concurrent shock are independent risk factors for 7-day death in elderly patients with acquired bloodstream infection. Day-1 SOFA score>7, chronic renal insufficiency, and concurrent shock are independent risk factors for 28-day mortality in elderly patients with acquired bloodstream infection. Conclusion: The incidence of acquired bloodstream infections in the elderly was 1.37%. The 7-day and 28-day mortality rates were 8.10% and 22.38%, respectively. Concurrent shock is 26.7%. The 28-day mortality rate of concurrent shock patients was 48.21%. The best outcome score for the 7-day prognosis of elderly patients with acquired bloodstream infection was the Day-1APACHE-II score, followed by the Day-1 SOFA score. The best score for the 28-day prognostic assessment was the Day-1 SOFA score.
La Colección Zavaleta y su traslado al <i>Field Museum</i> de Chicago: una aproximación desde la vida social de los objetos
Authors: Gluzman Geraldine A. 
Published: May 2019

La colección de objetos arqueológicos y restos óseos humanos depositada en el Field Museum of Natural History de Chicago se inscribe dentro de una compleja trama histórica que este artículo busca explorar. Procedentes de tres provincias del Noroeste argentino (Salta, Tucumán y Catamarca) fueron adquiridos en 1904 durante la Louisiana Purchase Exposition llevada a cabo en Saint Louis (Missouri, Estados Unidos) mediante su compra directa a Manuel B. Zavaleta, su colector. Se propone analizar algunas de las principales condiciones sociales y políticas que permitieron su exposición en Saint Louis hasta su actual resguardo en el museo de Chicago y, en baja cantidad de bienes, posterior intercambio con otras instituciones. Se empleará el concepto de campo científico como espacio de tensiones entre diversos actores, instituciones y actividades para dar cuenta de las vicisitudes sufridas por las piezas desde su recuperación en Argentina. Una aproximación desde la vida social de los objetos permitirá comprender cómo los bienes arqueológicos fueron motivo de múltiples disputas sociales y de diversas lecturas de significación acerca del pasado y del futuro, no solo de las piezas sino también de los grupos indígenas contemporáneos en las postrimerías del siglo XIX e inicios del XX.
PELATIHAN PENELITIAN TINDAKAN KELAS (PTK) BAGI GURU SD NEGERI DI KECAMATAN SUKARAJA KABUPATEN SELUMA
Authors: Dihamri Dihamri , Haimah Haimah , Srifitriani Abditama 
Published: May 2019

Guru- guru Sekolah Dasar (SD) kesulitan naik pangkat khususnya dari golongan IV/a ke IV/b karena tidak dapat memenuhi persyaratan dalam bidang karya tulis ilmiah. Tujuan akhir pengabdian ini adalah agar guru-guru SD memiliki kompetensi menyusun proposal Penelitian Tindakan Kelas (PTK). Pelatihan akan bermanfaat bagi guru dalam peningkatan profesional dan memenuhi persyaratan kenaikan pangkat. Metode yang digunakan untuk mencapai tujuan tersebut adalah pelatihan dan bimbingan. Guru-guru dilatih penyusunan proposal PTK. Pelatihan dilaksanakan enam kali pertemuan, bimbingan kelompok tiga kali pertemuan dan bimbingan individu masing-masing tiga kali pertemuan. Bimbingan juga dilakukan lewat hp (handphone), wa (WhatsApp), dan email. Selama kegiatan dilakukan monitoring dan setelah kegiatan diadakan evaluasi. Kegiatan pelatihan dilaksanakan sesuai rencana. Hasilnya guru-guru dapat menyusun proposal PTK bahkan ada yang dapat menyusun laporan PTK.
Computed tomography-guided Tru-cut biopsy of lung mass, as an important diagnostic tool: Histopathological characteristics, age, sex distribution, and risk factors in Misurata Cancer Center, Libya
Authors: Sidoun Mohamed Alhashmi M. , Topov Yasin , Elfageh Mohamed A. , Mansour Noura A. , Jwaid Abdullah A. , Jahan Alhadi M. , Alragig Mussa A. 
Published: May 2019

Abstract
Background: Lung biopsies may be classified according to the method of access or by the reason for biopsy. Tru-cut biopsy is a simple, relatively safe, rapid, and reliable technique for the diagnosis of lung mass lesions, particularly with the aid of computed tomography (CT) scan. This procedure is commonly used worldwide to detect different kinds of lung tumors, but its usefulness in Libya is not yet studied.
Objectives: The aim of this study was to assess the usefulness of Tru-cut biopsy as a diagnostic method in lung tumors and also to determine the incidence of lung cancer in various ages and sex groups and in relation to smoking data.
Patients and Methods: Retrospective study was done on 136 patients who underwent CT-guided Tru-cut biopsy from January 2012 to March 2015. The included patients have lung mass lesions suspected to be neoplastic according to chest radiograph and/or CT scan.
Results: We found biopsies and histopathology reports of 136 cases. The patients’ age was from 20 to 85 years with the peak incidence in the sixth and seventh decades. The benign lesions were 18 (13.23%), and malignant lesions were 118 (86.76%) documented microscopically. The most common tumor was squamous cell carcinoma (25.17%), followed by adenocarcinoma (23.02%) and small cell lung carcinoma (17.26%). Nonspecific inflammation was found in 8.63%.
Conclusion: CT-guided Tru-cut biopsy is a simple, safe, and reliable procedure with high diagnostic accuracy for the diagnosis and subtyping of lung cancer. The definitive result of malignancy is a base for correct decision for the patient's treatment after careful clinical correlation with performance state, radiology findings, and complete serological investigations.
Slice-torus Concordance Invariants and Whitehead Doubles of Links
Authors: Cavallo Alberto , Collari Carlo 
Published: May 2019

AbstractIn this paper we extend the definition of slice-torus invariant to links. We prove a few properties of the newly-defined slice-torus link invariants: the behaviour under crossing change, a slice genus bound, an obstruction to strong sliceness, and a combinatorial bound. Furthermore, we provide an application to the computation of the splitting number. Finally, we use the slice-torus link invariants and the Whitehead doubling to define new strong concordance invariants for links, which are proven to be independent of the corresponding slice-torus link invariant.
La consecución de la alfabetización universal en el Alto Nervión (País Vasco)
Authors: Merino Zulueta Aketza 
Published: May 2019

El objetivo del presente trabajo consiste en realizar un estudio de caso concreto acerca del proceso de alfabetización en la comarca vasca del Alto Nervión, entre Araba/Álava y Bizkaia. Basándose en la necesidad de huir de generalizaciones y resaltar matices, valoramos los avances de esta comarca en relación al calendario marcado por otras zonas próximas, otras provincias o España en su conjunto, en el contexto de los estudios que analizan las capacidades alfabetizadoras como elemento esencial para la mejora del capital humano, factor necesario aunque no suficiente para el desarrollo económico, reflexión a la que se dedica la primera parte del trabajo. A continuación se realiza un recorrido que abarca desde los primeros datos sobre alfabetización que aparecen a mediados del siglo XIX, hasta 1935, momento en que la comarca ya ha alcanzado la alfabetización universal, pasando por una fase intermedia protagonizada por una importante crisis económica y demográfica. El estudio se lleva a cabo mediante fuentes estadísticas como son los padrones municipales de población que reflejan la adquisición por parte de cada individuo de las capacidades de leer y escribir. El análisis nos lleva a concluir que el proceso de alfabetización, a pesar de enfrentar importantes desequilibrios territoriales, de género o socioprofesionales, se había completado ya antes de la Guerra Civil, capacitando a su capital humano para el desarrollo económico que el Alto Nervión estaba emprendiendo.
La Semana Trágica de Barcelona de 1909 en la historiografía escolar: del africanismo a la posmodernidad
Authors: Castillejo Cambra Emilio 
Published: May 2019

El tratamiento de los sucesos de la Semana Trágica de Barcelona de 1909 que hizo la historiografía escolar antes de 1975 (final de la dictadura de Franco), estuvo condicionado por factores diversos: sacralización del orden social y del sistema de la Restauración, el africanismo, el pensamiento eclesial. Desde esta fecha, a pesar de los avances de la historiografía profesional y de las libertades democráticas, comprobamos que los manuales de Historia siguen sin dar las claves para evidenciar las complicidades que sostienen el sistema de poder frente al que se produce la revuelta de julio de 1909 en Barcelona, y las ideologías que sirven para legitimarla: anticolonialismo, anticapitalismo, antimilitarismo y anticlericalismo. En esta ocultación intervienen reminiscencias del pasado (palabras-trampa del pensamiento eclesial, del militarismo, del colonialismo...), tabúes sociales sobre la Iglesia católica y el Ejército, y la liquidez y falta de compromiso del pensamiento posmoderno imperante.
Lost in Warsaw: the subversion of multilingual humour in the Italian subtitles to the Polish war comedy Giuseppe in Warsaw (1964)
Authors: Wozniak Monika 
Published: May 2019

In 1964, many decades before multilingual movies have become fashionable, a Polish director, Stanisław Lenartowicz, made a war comedy called “Giuseppe in Warsaw”. It narrates the adventures of an Italian soldier who on his way home from the Russian front during World War II is stranded in Poland. Pseudo-language, translation, mistranslation, and mock translation figure conspicuously in the movie, which shows a series of clashes between Polish, German and Italian languages in the most improbable combinations. The original film used no subtitles, because the linguistic chaos was pivotal to showing the absurdity of the war through the deforming lenses of the comedy. This paper analyses various mechanisms of the multilingual humour in the original film and in its subtitled version in Italian, in order to see how the dynamics of humour change in the case of L3TT which becomes L2 in translation (Italian), especially when the point of the view of the audience is subverted and the viewers identify with the protagonist rather than the Polish characters in the movie.
Imagery ability of elite level athletes from individual vs. team and contact vs. no-contact sports
Authors: Di Corrado Donatella , Guarnera Maria , Vitali Francesca , Quartiroli Alessandro , Coco Marinella 
Published: May 2019

Background
In the sport context, imagery has been described as the condition in which persons imagine themselves while executing skills to deal with the upcoming task or enhance performance. Systematic reviews have shown that mental imagery improves performance in motor tasks

Methods
The aim of the present study was to explore whether imagery vividness (i.e., the clarity or realism of the imagery experience) and controllability (i.e., the ease and accuracy with which an image can be manipulated mentally) differ by sport types (team vs. individual and contact vs. non-contact). Participants were athletes from team contact and non-contact sports (rugby and volleyball, respectively), and individual contact and non-contact sports (karate and tennis, respectively) between the ages of 20 and 33 years (M = 24.37, SD = 2.85). The participants completed the Vividness of Visual Imagery Questionnaire, the Vividness of Movement Imagery Questionnaire-2, and the Mental Image Transformation Tasks.

Results
A 2 ×2 × 2 (gender × 2 contact-no-contact × 2 sport type) between groups MANOVA showed differences in imagery ability by sport type. Practical indications deriving from the findings of this study can help coaches and athletes to develop mental preparation programs using sport-specific imagery.
Joint action of miR‐126 and MAPK/PI3K inhibitors against metastatic melanoma
Authors: Pedini Francesca , De Luca Gabriele , Felicetti Federica , Puglisi Rossella , Boe Alessandra , Arasi Maria Beatrice , Fratini Federica , Mattia Gianfranco , Spada Massimo , Caporali Simona , Biffoni Mauro , Giuliani Alessandro , Carè Alessandra , Felli Nadia 
Published: May 2019

Emerging data support the rationale of combined therapies in advanced melanoma. Specifically, the combined use of drugs with different mechanisms of action can reduce the probability of selecting resistant clones. To identify agents active against melanoma cells, we screened a library of 349 anti‐cancer compounds, currently in clinical use or trials, and selected PIK‐75, an inhibitor of the phosphatidylinositol 3‐kinase/protein kinase B (PI3K/AKT) pathway, as the ‘top active’ drug. PIK‐75 was then used alone or in combination with vemurafenib, the first BRAF inhibitor approved for patients with melanoma harboring BRAF mutations. We identified a combined dose of PIK‐75 and vemurafenib that inhibited both the PI3K/AKT and mitogen‐activated protein kinase pathways, thereby overcoming any compensatory activation. In view of the important tumor suppressor function induced by restoring expression of microRNA (miR)‐126 in metastatic melanoma cells, we examined whether miR‐126 has a synergistic role when included in a triple combination alongside PIK‐75 and vemurafenib. We found that enforced expression of miR‐126 (which alone can reduce tumorigenicity) significantly increased PIK‐75 activity when used as either a single agent or in combination with vemurafenib. Interestingly, PIK‐75 proved to be effective against early passage cell lines derived from patients’ biopsies and on melanoma cell lines resistant to either vemurafenib or dabrafenib, thus suggesting that it potentially has the capability to overcome drug resistance. Finally, the synergistic role played by miR‐126 in combination with vemurafenib and/or PIK‐75 was demonstrated in vivo in mouse xenograft models, in which tumor growth inhibition was associated with increased apoptosis. These results not only show the efficacy of PIK‐75 and vemurafenib co‐treatment but also indicate that restoration of miR‐126 expression in advanced melanoma can enhance their antitumor activity, which may possibly allow dose reduction to decrease adverse events without reducing the therapeutic benefits.
Racial and Ethnic Differences in the Prevalence and Time to Onset of Manifestations of Systemic Lupus Erythematosus: The California Lupus Surveillance Project
Authors: Maningding Ernest , Dall'Era Maria , Trupin Laura , Murphy Louise B. , Yazdany Jinoos 
Published: May 2019

ObjectiveThe California Lupus Surveillance Project (CLSP) is a population‐based registry of individuals with systemic lupus erythematosus (SLE) residing in San Francisco County, California from 2007 to 2009, with a special focus on Asian/Pacific Islander and Hispanic patients. We used retrospective CLSP data to analyze racial and ethnic differences in lupus manifestations and in the timing and risk of developing severe manifestations.MethodsA total of 724 patients with SLE were retrospectively identified. Prevalence ratios (PRs) of SLE manifestations were calculated using Poisson regression models stratified by race/ethnicity and adjusted for sex, age at SLE diagnosis, and disease duration. We studied onset of severe SLE manifestations after SLE diagnosis using Kaplan‐Meier methods to examine time‐to‐event and Cox proportional hazards regression models to estimate hazard ratios (HRs). White patients were the referent group in all analyses.ResultsAfrican Americans, Asian/Pacific Islanders, and Hispanic patients had increased prevalence of renal manifestations (PR 1.74 [95% confidence interval (95% CI) 1.40–2.16], PR 1.68 [95% CI 1.38–2.05], and PR 1.35 [95% CI 1.05–1.74], respectively). Furthermore, African Americans had increased prevalence of neurologic manifestations (PR 1.49 [95% CI 1.12–1.98]), and both African Americans (PR 1.09 [95% CI 1.04–1.15]) and Asian/Pacific Islanders (PR 1.07 [95% CI 1.01–1.13]) had increased prevalence of hematologic manifestations. African Americans, Asian/Pacific Islanders, and Hispanic patients, respectively, had higher risk of developing lupus nephritis (HR 2.4 [95% CI 1.6–3.8], HR 4.3 [95% CI 2.9–6.4], and HR 2.3 [95% CI 1.4–3.8]) and thrombocytopenia (HR 2.3 [95% CI 1.1–4.4], HR 2.3 [95% CI 1.3–4.2], and HR 2.2 [95% CI 1.1–4.7]). Asian/Pacific Islander and Hispanic patients had higher risk of developing antiphospholipid syndrome (HR 2.5 [95% CI 1.4–4.4] and HR 2.6 [95% CI 1.3–5.1], respectively).ConclusionThis is the first epidemiologic study comparing lupus manifestations among 4 major racial and ethnic groups. We found substantial differences in the prevalence of several clinical SLE manifestations among racial/ethnic groups and discovered that African Americans, Asian/Pacific Islanders, and Hispanic patients are at increased risk of developing several severe manifestations following a diagnosis of SLE.
A Simple Strategy towards Highly Conductive Silver‐Nanowire Inks for Screen‐Printed Flexible Transparent Conductive Films and Wearable Energy‐Storage Devices
Authors: Li Dongdong , Liu Xing , Chen Xin , Lai Wen‐Yong , Huang Wei 
Published: May 2019

AbstractPrintable silver‐nanowire (Ag NW) inks with simple formulation, low cost, and high conductivity are developed and screen printed on flexible poly(ethylene terephthalate) substrates. By using ultralong Ag NWs (≈75 µm in length) as the conductor, the screen‐printed Ag NW patterns exhibit exceptional conductivity (up to 8.32 × 103 S cm−1) and excellent mechanical robustness. Rheological behavior suitable for screen printing is achieved by adjusting the formulation of the inks, which assures neat and smooth screen‐printed lines with resolution as high as 100 µm. Uniform and honeycomb‐structured Ag NW transparent conductive films with superior flexibility and optical transmittance ≈80% are obtained by screen printing the Ag NW inks. Flexible all‐solid‐state supercapacitors based on Ag NW/PEDOT:PSS electrodes reach areal specific capacitance as high as 8.58 mF cm−2, a value threefold higher than that of pristine PEDOT:PSS electrodes. Moreover, a high flexibility with a bending angle of 180° and long‐term stability with ≈90% capacitance retention over 2500 cycles, is also obtained, manifesting this material's great potential applications for flexible and wearable energy‐storage devices.
Silver nanoparticles promote osteogenic differentiation of human periodontal ligament fibroblasts by regulating the RhoA–TAZ axis
Authors: Xu Yunhe , Zheng Bowen , He Jia , Cui Zhao , Liu Yi 
Published: May 2019

AbstractSilver nanoparticles (AgNps) are well established antibacterial agents, which have been reported to promote osteogenesis of stem cells. Ras homolog gene family member A (RhoA) and Tafazzin (TAZ) have been recently shown to be involved in osteogenic differentiation. The present study aimed to evaluate the effects of AgNps on osteogenic differentiation of human periodontal ligament fibroblasts (HPDLFs), and investigate the underlying mechanisms of AgNps activity. 3‐(4,5‐Dimethylthiazol‐2‐yl)‐2,5‐diphenyltetrazolium bromide (MTT) assay was employed to determine the safe concentration of AgNps in HPDLFs. Using an alkaline phosphatase assay, Alizarin red S staining and detection of the expression of alkaline phosphatase (ALP), runt‐related transcription factor 2 (RUNX2), osteocalcin (OCN), osterix (OSX), and collagen‐I, we found that AgNps, at a concentration range of 25–100 μM, promoted osteogenic differentiation of HPDLFs in a dose‐dependent manner. We also found that 100 μM AgNps up‐regulated the active RhoA expression level. The results of ALP activity and expression of osteogenic markers showed that the effects of AgNps on osteogenic differentiation were abrogated by a RhoA pathway inhibitor, C3 reagent. Additionally, silencing of TAZ attenuated the AgNps‐induced osteogenic differentiation of HPDLFs, as shown by decreased ALP activity and down‐regulation of osteogenic markers. Interestingly, TAZ knockdown had a very small effect on the activity of RhoA, whereas C3 suppressed the expression of TAZ, indicating that TAZ was a downstream effector of RhoA. In conclusion, the present work demonstrated that AgNps promoted osteogenic differentiation of HPDLFs by activating the RhoA–TAZ axis.
pH‐Induced Fluorescence and Thermal Relaxation Rate Modulation in a Hydrazone Photoswitch
Authors: Shao Baihao , Aprahamian Ivan 
Published: May 2019

AbstractA recently developed family of bistable hydrazone‐based photochromic compounds open new possibilities for molecular machinists with their unique combination of properties. Herein we report on the effect of acid/protonation on the switching and fluorescence emission of a recently reported dimethyl amino hydrazone derivative (1). The fluorescence of 1 can be turned ON/OFF upon deprotonation/protonation cycles, and protonated 1 photoswitches efficiently. Meanwhile, acid catalysis leads to a dramatic acceleration of its thermal relaxation rate (from years to hours).