bluuebunny/crossref_metadata_2025_split huggingface dataset:
High-density Bacterial Nasal Carriage in Children Is Transient and Associated With Respiratory Viral Infections—Implications for Transmission Dynamics
Authors: Thors Valtyr , Christensen Hannah , Morales-Aza Begonia , Oliver Elizabeth , Sikora Paulina , Vipond Ian , Muir Peter , Finn Adam 
Published: November 2018

Background:
This longitudinal study describes the associations between respiratory viral infections, rhinitis and the prevalence and density of the common nasopharyngeal bacterial colonizers, Streptococcus pneumoniae (Sp), Moraxella catarrhalis (Mc), Haemophilus influenzae (Hi) and Staphylococcus aureus.

Methods:
In an observational cohort study, 161 children attending day care centers in Bristol, United Kingdom, were recruited. Monthly nasopharyngeal swabs were taken and stored frozen in Skim-milk, tryptone, glucose and glycerin broth (STGG) broth. Quantitative polymerase chain reaction was used for detection of respiratory viruses and 4 bacterial species. t tests and logistic regression models were used for analysis.

Results:
The frequent colonisers, Sp, Mc and Hi were more frequently found at high density in contrast to Staphylococcus aureus although temporally, high-density carriage was short lived. Respiratory viral infections and symptoms of rhinitis were both independently and consistently associated with higher bacterial density with an observed 2-fold increase in density for Sp, Mc and Hi (P = 0.004–0.017).

Conclusions:
For Sp and Hi, the association between young age and higher bacterial DNA density was explained by more frequent viral infection and increased nasal discharge, while the associations between some viral specie’s and some bacterial species’ density appear to be stronger than others. Increased colonization density and rhinitis may promote transmission of these commonly carried organisms.
Mathematical Models of Sleep and Circadian Rhythms: A Case for Using the 2-Process Model in Neuroscience Nursing
Authors: Mithani Sara , Fink Anne M. 
Published: November 2018

ABSTRACT
Acute and chronic neurological disorders impair sleep. Despite the availability of theoretical/mathematical frameworks about sleep, the nursing profession rarely incorporates these models. The purpose of this article was to analyze the 2-process model of sleep regulation using Fawcett and DeSanto-Madeya’s method, a systematic approach for determining whether a theory is relevant to nursing. The 2-process model has 3 concepts: process S (sleep-dependent process), process C (circadian-timing–dependent process), and total sleep propensity (summation of processes S and C). Nonnursing theories do not explicitly incorporate nursing metaparadigm concepts—person, health, environment, and nursing—but the 2-process model is congruent with nursing’s philosophy. The model guided studies quantifying sleep and circadian patterns in other fields, and nurses could use this framework to measure the impact of nursing interventions. Strengths of the 2-process model include parsimony (conciseness without oversimplification) and the ability to empirically test propositions related to processes S and C. The 2-process model is relevant to neuroscience nursing—by measuring sleep/circadian-related variables (electroencephalogram, core body temperature, salivary melatonin). Nurses have opportunities to design, test, and use interventions that improve sleep in patients with neurological conditions.
Alcohol Consumption as a Moderator of Anxiety and Sleep Quality
Authors: CHUEH Ke-Hsin , GUILLEMINAULT Christian , LIN Chia-Mo 
Published: November 2018

ABSTRACT

Background:
Although people who sleep poorly may attempt to relieve anxiety for better sleep quality, whether daily alcohol consumption is a factor that moderates anxiety and sleep disturbance is not known.

Purpose:
The aim of the study was to explore (a) the association between anxiety and sleep quality and (b) whether daily alcohol consumption acted as a moderator between anxiety and sleep quality in those who reported sleeping poorly.

Methods:
Eighty-four participants aged 20–80 years who reported poor sleep (Pittsburgh Sleep Quality Index > 5) in northern Taiwan were enrolled in this cross-sectional study. A structured questionnaire covering demographics (including daily alcohol consumption), level of anxiety, level of depression, and perceived sleep quality was used to collect data.

Results:
The participants were mostly women (72.6%). The mean age was 41.81 (SD = 12.62) years; 51.2%, 19.0%, 13.1%, and 14.3%, respectively, had minimal, mild, moderate, and severe anxiety. After adjusting for factors related to sleep quality using multiple regression analysis, receiving sleep therapy, consuming alcohol on a daily basis, and having anxiety were found to be predictors of poor sleep quality. Moreover, daily alcohol consumption was found to moderate the relationship between anxiety and sleep quality.

Conclusions/Implications for Practice:
People who sleep poorly should avoid misusing alcohol to self-treat poor sleep quality or anxiety and should instead utilize sleep hygiene education and mental healthcare. Daily alcohol consumption may be a moderator between anxiety status and sleep quality.
Prosthetic Limb User Experiences With Crossover Feet: A Pilot Focus Group Study to Explore Outcomes That Matter
Authors: McDonald Cody L. , Cheever Sarah M. , Morgan Sara J. , Hafner Brian J. 
Published: November 2018

ABSTRACT

Introduction
Many different prosthetic feet are available to meet the diverse needs of people with lower-limb amputation. Current methods used to assess comparative effectiveness of prosthetic feet may not align with outcomes that are most important to people with lower-limb amputation. User participation in qualitative research is one approach to guide selection of outcome measures for clinical practice and quantitative research studies. This pilot study examined outcomes of importance to people who have used both energy storing and crossover prosthetic feet.

Materials and Methods
An in-person focus group of people with lower-limb amputation was conducted. Inclusion criteria were as follows: 18 years of age or older, lower-limb amputation, previous use of an energy storing foot and crossover foot, and a minimum of 1 year prosthesis use.

Results
Five participants with lower-limb amputation (4 males/1 female), aged 41 to 59 years (mean, 45.6 ± 7.7 years), participated in the focus group. Three participants had unilateral transtibial amputations; one had bilateral transtibial amputations; and another had bilateral involvement with a transtibial and partial-foot amputation. All participants reported daily use of a prosthesis (mean, 15.2 ± 1.1 hours). Three categories of themes arose from this focus group: direct outcomes, external influences, and indirect outcomes. Direct outcomes included balance and stability, endurance and sustained gait quality, and naturalness. External influences included peer and prosthetist interactions. Indirect outcomes included increased confidence and expanded mobility. Outcome measures available to assess identified constructs were suggested.

Conclusions
Engagement of prosthesis users through qualitative research methods can inform the choice of outcome measures used to assess clinical outcomes or evaluate the effectiveness of prosthetic devices.
Crystalloid fluid administration was associated with outcomes in pediatric patients with severe sepsis or septic shock
Authors: Zhang Shan , Dai Xiaoke , Guo Chunbao 
Published: November 2018

Abstract
Intravenous fluid prescription plays an important role in sepsis management, which may be associated with patient prognosis. The objective of the present study was to determine if the administration of crystalloid fluids is associated with clinical outcome for patients with severe sepsis and septic shock.
The medical records of 79 patients with severe sepsis or septic shock at an academic tertiary care hospital between 2011 and 2016 were reviewed retrospectively. The patients were dichotomized based on the median 3-day amount of corrected crystalloid fluids as low (<193 mL/kg) versus high (>193 mL/kg). The primary outcome measure was mortality. Secondary outcome measures included length of stay in the pediatric intensive care unit (PICU), usage of mechanical ventilation, etc.
The most common bacterial pathogens were Escherichia coli and Klebsiella spp. with a strikingly high number of multidrug-resistant infections (10.1%). The most common site of infection was of abdominal origin. Patients who received larger amounts of crystalloids were more likely to have lower weight and underlying comorbidities (high PRISM score). Although fluid intake was different in the 2 groups, output volumes were almost the same; therefore, a positive fluid balance was present in the high crystalloid patients. The incidence of mortality increased as the accumulated 3-day amount of crystalloid fluids administered increased. The total length of stay in the PICU was longer for patients who received high volume crystalloid fluid (15.8 ± 7.8 days) than for patients who received the lower volume (9.7 ± 5.3 days, P = .026).
A higher amount of 3-day crystalloid administration was unfavorable for postoperative outcomes in children with sepsis and septic shock; these patients experienced higher PICU mortality, longer PICU stays, and more ventilator days. More study on the benefits and harms of fluid in children are needed to improve patient safety and the quality of care that would facilitate better outcomes.
Clinical and imaging features of vertebrobasilar dolichoectasia combined with posterior circulation infarction
Authors: Wang Feng , Hu Xiao-Yun , Wang Tao , Fang Xiang-Ming , Dai Zheng , Guo Dao-liu , Mao Xu-Qiang , Cui Zhi-Ming 
Published: November 2018

Abstract
This study aims to analyze the clinical and imaging features of vertebrobasilar dolichoectasia (VBD) combined with posterior circulation infarction, and to explore risk factors for the occurrence of posterior circulation infarction in VBD patients.
VBD patients were divided into 2 groups, according to the results of the imaging examination: posterior circulation infarction group and nonposterior circulation infarction group. The demographics, vascular risk factors, imaging, and other clinical data of the VBD patients were collected and retrospectively compared, and the risk factors for the occurrence of posterior circulation infarction in VBD patients were analyzed. The relationship between imaging features of the VBD blood supply artery and the infarct site was also analyzed.
A total of 56 VBD patients were included into the analysis. Among these patients, 26 patients had posterior circulation infarction. Infarction occurred in the blood supply area of the posterior cerebral artery in 14 patients. The difference in the height of the basilar artery bifurcation between patients with vertebrobasilar artery blood supply area infarction and patients with posterior cerebral artery supply area infarction was statistically significant. Hypertension and posterior circulation intracranial atherosclerosis were the risk factors for posterior circulation infarction in VBD patients.
Elevated basilar artery bifurcation is a risk factor for infarction in the posterior cerebral artery supply area in VBD patients. Posterior circulation infarction in VBD may be the comprehensive result of multiple factors, such as congenital defects of the basilar artery wall, hypertension, and atherosclerotic lesions.
Enhanced recovery care versus traditional care following laminoplasty
Authors: Li Jun , Li Hao , Xv Zheng-kuan , Wang Jian , Yu Qun-fei , Chen Gang , Li Fang-cai , Ren Ying , Chen Qi-xin 
Published: November 2018

Abstract
Enhanced recovery after surgery (ERAS) has been shown to shorten length of hospital stay and reduce perioperative complications in many types of surgeries. However, there has been a paucity of research examining the application of ERAS to major spinal surgery. The current study was performed to compare complications and hospital stay after laminoplasty between an ERAS group and a traditional care group.
The ERAS group included 114 patients who underwent laminoplasty managed with an ERAS protocol between January 2016 and June 2017. The traditional care group included 110 patients, who received traditional perioperative care between November 2014 and December 2015. Postoperative hospital stay (POPH), physiological function, postoperative visual analogue scale (VAS) pain score, and postoperative complications were compared between the 2 groups.
The mean POPH was significantly shorter in the ERAS group than traditional care group (5.75 ± 2.46 vs. 7.67 ± 3.45 d, P < .001). ERAS protocol significantly promoted postoperative early food-taking (8.45 ± 2.94 h vs 21.64 ± 2.66 h, P < .001), reduced the first time of assisted walking (30.79 ± 14.45 vs. 65.24 ± 25.34 h, P < .001), postoperative time of indwelling urinary catheters (24.76 ± 12.34 vs. 53.61 ± 18.16 h, P < .001), and wound drainage catheters (43.92 ± 7.14 vs. 48.85 ± 10.10 h, P < .001), as compared with the traditional care group. Pain control was better in the ERAS group than traditional care group in terms of mean VAS score (2.72 ± 0.46 vs. 3.35 ± 0.46, P < .001) and mean maximum VAS score (3.76 ± 1.12 vs. 4.35 ± 1.15, P < .001) in 3 days after surgery. The morbidity rate was 21.05% (24 of 114 patients) in the ERAS group and 20.90% (23 of 110 patients) in the control group (P = .75).
The ERAS protocol is both safe and feasible for patients undergoing laminoplasty, and can decrease the length of postoperative hospitalization without increasing the risk of complications.
A new classification of parathyroid glands to evaluate in situ preservation or autotransplantation during thyroid surgery
Authors: Su Anping , Gong Yanping , Wei Tao , Gong Rixiang , Li Zhihui , Zhu Jingqiang 
Published: November 2018

Abstract
The indication for autotransplantation of parathyroid glands is still controversial. A new classification of parathyroid glands based on the positional relationship among parathyroid glands, thyroid gland and thymus was created to decide in situ preservation or autotransplantation during thyroid surgery.
A retrospective study included patients with papillary thyroid cancer who underwent total thyroidectomy with bilateral central lymph node dissection between November 2014 and November 2016. According to the application of the new classification (December 2015–November 2016) or traditional method (preservation of all functional parathyroid glands in situ, November 2014–November 2015), the patients were divided into new classification and traditional groups.
The traditional method was utilized in 288 patients who underwent surgery during the first half of the study, while the new classification was applied to 249 patients during the latter half of the study. The incidence of transient hypoparathyroidism was 43.0% (107/249) in new classification group and 35.8% (103/288) in the traditional group, respectively (P = .093). The corresponding incidence of permanent hypoparathyroidism was 0.4% (1/249) and 4.5% (13/288) (P = .002).
The new classification of parathyroid glands potentially reflects the difficulty of preservation and helps to make a reasonable decision on preservation or autotransplantation of a parathyroid gland, which may minimize the incidence of permanent hypoparathyroidism.
Combination of meshed dermis graft and cultured epithelial autograft for massive burns
Authors: Hayashi Minoru , Yoshitake Kotaro , Tokunaka Ryohei , Yoshida Yuki , Oshima Mikiko , Tatsuta Sayo , Hamada Taishi , Kamitomo Ayako , Hamajima Akito 
Published: November 2018

Abstract

Rationale:
This study reviewed the use of a combination of meshed dermis graft and cultured epithelial autografts (CEA) made in Japan “JACE” (JACE; Japan Tissue Engineering Co., Ltd. Japan) for the treatment of massively burns. JACE is a Green-type CEA. We recently described a method in which we prepare the wound bed for burned patients by using artificial dermis and graft with JACE on a meshed 6:1 split-thickness autograft. In this report, we used a meshed 3:1 split-thickness dermis graft without epithelial cells. There are several reports of combination of using CEA on meshed split-thickness autograft, however this is the first report of using CEA on meshed split-thickness dermis graft.

Patient concerns and diagnosis:
Between March 2015 and August 2017, 3 burn patients were enrolled in this study. The patients ranged in age from 51 to 66 years. All 3 patients suffered severe burn injury that caused by flame. % Total Body Surface Area (TBSA) burned were ranged from 37.5% to 69%.

Interventions:
All patients received surgical treatment with tangential excision within a week from admission. We implanted artificial dermis immediately after debridement. Basically, we applied meshed 6:1 split-thickness autografts to the wound bed and covered with JACE. However, in the absence of split-thickness autografts, we used a meshed 3:1 split-thickness dermis graft instead of a meshed 6:1 split-thickness autograft.

Outcomes:
At 3 weeks after the transplantation of JACE, the take rate for JACE sheets was >60% on the meshed 3:1 split-thickness dermis graft. Furthermore, almost all of the burn wounds had healed at 6 weeks after surgery.

Lessons:
We observed good results by grafting JACE on meshed 3:1 dermis graft. With this new method, it is possible to cover a large burn wound by harvesting tissue from only a small site.
Comparison of the effects of different positive end-expiratory pressure levels on respiratory mechanics and oxygenation in laparoscopic surgery
Authors: Wang Min , Geng Nan , Gao Ya , Zhang Yan , Wang Yingbin , Shen Xiping , Tian Jinhui , Wang Bo 
Published: November 2018

AbstractBackground:Several studies have observed the good effects of positive end-expiratory pressure (PEEP) application in laparoscopic surgeries, such as counteracted intraoperative atelectasis, improved respiratory mechanics, and gas exchange. However, evidence of systematic comparisons of different PEEP levels is short, and the optimal level of PEEP during laparoscopy remains unknown and controversial. The study aims to compare the effects of different PEEP levels on respiratory mechanics and oxygenation in laparoscopic surgery using network meta-analyses.Methods:To identify relevant studies, a systematic search will be conducted among electronic databases, including PubMed, Cochrane Library, EMBASE, and Web of Science. We will include randomized controlled trials (RCTs). The risk of bias in the included RCTs will be assessed using the Cochrane bias risk tool. Network meta-analysis will be performed using STATA 15.0, and R 3.4.1 software.Results:This study is ongoing and the results will be published in a peer-reviewed journal.Conclusion:The results of this study will be sent to clinicians and healthcare providers in the National Health Service, which is expected to help clinicians make more informed treatment decisions and facilitate further research on the use of PEEP during surgery.PROSPERO registration number:CRD42018093537.
Endoscopic repair of spontaneous esophageal rupture during gastroscopy
Authors: He Feiyun , Dai Mugen , Zhou Jiwang , He Jiansheng , Ye Bin 
Published: November 2018

Abstract

Rationale:
Most of esophageal rupture is a very serious life-threatening benign gastrointestinal tract disease with high mortality. However, there are a few cases of spontaneous esophageal rupture during gastroscopy.

Patient concerns:
A 57-year-old man who underwent a routine diagnostic gastroscopy due to food obstruction was reported. During the gastroscopy, he vomited severely, which was followed by severe left chest pain radiating into the back and upper abdomen. The diagnosis was made by computed tomography (CT) scan without delay. Enhanced CT showed extensive mediastinal emphysema, a small amount of left pleural effusion, and a 6 cm tear was confirmed in the lower esophagus posteriorly.

Diagnoses:
The patient was diagnosed with an intrathoracic rupture type of spontaneous esophageal rupture.

Interventions:
The patient received endoscopic suturing techniques under endotracheal intubation, titanium clip clamping, and over the scope clip (OTSC) sealing.

Outcomes:
The procedure was smooth and the patient recovered well after operation.

Lessons:
During gastroscopy, the risk of esophageal rupture should be considered due to sudden pain caused by severe nausea and vomiting. Esophageal rupture can rapidly lead to severe life-threatening infections such as empyema and mediastinitis. Therefore, awareness of this condition is important so that appropriate treatment can rapidly be implemented to increase the likelihood of a good outcome.
Management of placental site trophoblastic tumor
Authors: De Nola Rosalba , Schönauer Luca Maria , Fiore Maria Grazia , Loverro Matteo , Carriero Carmine , Di Naro Edoardo 
Published: November 2018

Abstract

Rationale:
Placental site trophoblastic tumor (PSTT) is a very rare malignant tumor, belonging to a family of pregnancy-related illnesses, called gestational trophoblastic diseases (GTD). Less than 300 cases of PSTT have been reported in literature, with an incidence of ≈ 1/50,000–100,000 pregnancies representing only 0.23% to 3.00% of all GTDs.

Patient concerns:
Our report describes 2 additional cases of PSTT outlining their main diagnostic features and the subsequent management. The first case presented contemporary to a persistent hydatidiform mole in a 37-year-old woman, para 2042; whereas the second one originated 5 years after a miscarriage in 43-year-old woman, para 1031 with a previous diagnosis of breast cancer, and shared some features with placental site nodule (PSN), a benign condition.

Diagnosis:
The first case had a difficult diagnosis because there was an amenorrhea of 11th week with high serum beta-human chorionic gonadotropin (beta-HCG) and an initial ultrasound image of vesicular mole. After the Dilatation and Curettage, histology confirmed the previous hypothesis. However, the final histology of PSTT was obtained after major surgery. On the contrary, the diagnosis of the second case was less challenging but surprising, thanks to a routine trans-vaginal ultrasound showing a suspicious endometrial thickness positive for PSTT at a subsequent hysteroscopic guided biopsy.

Interventions:
The treatment consisted of hysterectomy and subsequent follow up. Lymphadenectomy or lymph node sampling were not performed due to the initial stage of the disease.

Outcomes:
In the first case, there were high values of serum beta-HCG that plummeted after the surgery, whereas in the second one they had been always negative. Hereafter, both went through a follow up with periodic serum oncological markers, imaging studies and clinical evaluation, which have showed negative result for 3 years and 15 months, respectively.

Lessons:
A detailed gynecological ultrasound examination could be extremely helpful to understand the next diagnostic step of echo-guided D&C or hysteroscopic biopsy and for a pre-operative staging assessment. On the contrary, determining the serum beta-HCG's curve is crucial just in case of an initial positive value to pursue clinical evaluation and follow-up. In case of good prognostic factors, the main therapy remains hysterectomy.