bluuebunny/crossref_metadata_2025_split huggingface dataset:
Primary fatty amides in plasma associated with brain amyloid burden, hippocampal volume, and memory in the European Medical Information Framework for Alzheimer's Disease biomarker discovery cohort
Authors: Kim Min , Snowden Stuart , Suvitaival Tommi , Ali Ashfaq , Merkler David J. , Ahmad Tahmina , Westwood Sarah , Baird Alison , Proitsi Petroula , Nevado‐Holgado Alejo , Hye Abdul , Bos Isabelle , Vos Stephanie , Vandenberghe Rik , Teunissen Charlotte , ten Kate Mara , Scheltens Philip , Gabel Silvy , Meersmans Karen , Blin Olivier , Richardson Jill , De Roeck Ellen , Sleegers Kristel , Bordet Régis , Rami Lorena , Kettunen Petronella , Tsolaki Magda , Verhey Frans , Sala Isabel , Lléo Alberto , Peyratout Gwendoline , Tainta Mikel , Johannsen Peter , Freund‐Levi Yvonne , Frölich Lutz , Dobricic Valerija , Engelborghs Sebastiaan , Frisoni Giovanni B. , Molinuevo José L. , Wallin Anders , Popp Julius , Martinez‐Lage Pablo , Bertram Lars , Barkhof Frederik , Ashton Nicholas , Blennow Kaj , Zetterberg Henrik , Streffer Johannes , Visser Pieter J. , Lovestone Simon , Legido‐Quigley Cristina 
Published: May 2019

AbstractIntroductionA critical and as‐yet unmet need in Alzheimer's disease (AD) is the discovery of peripheral small molecule biomarkers. Given that brain pathology precedes clinical symptom onset, we set out to test whether metabolites in blood associated with pathology as indexed by cerebrospinal fluid (CSF) AD biomarkers.MethodsThis study analyzed 593 plasma samples selected from the European Medical Information Framework for Alzheimer's Disease Multimodal Biomarker Discovery study, of individuals who were cognitively healthy (n = 242), had mild cognitive impairment (n = 236), or had AD‐type dementia (n = 115). Logistic regressions were carried out between plasma metabolites (n = 883) and CSF markers, magnetic resonance imaging, cognition, and clinical diagnosis.ResultsEight metabolites were associated with amyloid β and one with t‐tau in CSF, these were primary fatty acid amides (PFAMs), lipokines, and amino acids. From these, PFAMs, glutamate, and aspartate also associated with hippocampal volume and memory.DiscussionPFAMs have been found increased and associated with amyloid β burden in CSF and clinical measures.
Response invalidity in empirical research: Causes, detection, and remedies
Authors: Edwards Jeffrey R. 
Published: May 2019

AbstractResearch in behavioral operations management and related areas relies heavily on self‐report measures. The utility of such measures depends on the extent to which the responses are valid, meaning they correspond to the thoughts and beliefs of respondents with regard to the phenomena under study. Response validity is undermined when respondents are unwilling or unable to provide adequate responses to survey questions, an issue that has generated an array of methods for screening and evaluating survey data and dealing with dubious responses. This article uses the work of Abbey and Meloy (2017) as a point of departure to examine the causes, detection, and remedies of response invalidity. The article concludes with recommendations for future research that treats response validity and its dimensions as methods factors that should be formally incorporated into statistical models.
Microdroplet nucleation by dissolution of a multicomponent drop in a host liquid
Authors: Tan Huanshu , Diddens Christian , Mohammed Ali Akash , Li Junyi , Versluis Michel , Zhang Xuehua , Lohse Detlef 
Published: May 2019

Multicomponent liquid drops in a host liquid are very relevant in various technological applications. Their dissolution or growth dynamics is complex. Differences in solubility between the drop components combined with the solutal Marangoni effect and natural convection contribute to this complexity, which can be even further increased in combination with the ouzo effect, i.e. the spontaneous nucleation of microdroplets due to composition-dependent miscibilities in a ternary system. The quantitative understanding of this combined process is important for applications in industry, particularly for modern liquid–liquid microextraction processes. In this work, as a model system, we experimentally and theoretically explore water–ethanol drops dissolving in anethole oil. During the dissolution, we observed two types of microdroplet nucleation, namely water microdroplet nucleation in the surrounding oil at drop mid-height, and oil microdroplet nucleation in the aqueous drop, again at mid-height. The nucleated oil microdroplets are driven by Marangoni flows inside the aqueous drop and evolve into microdroplet rings. A one-dimensional multiphase and multicomponent diffusion model in combination with thermodynamic equilibrium theory is proposed to predict the behaviour of spontaneous emulsification, i.e. microdroplet nucleation, that is triggered by diffusion. A scale analysis together with experimental investigations of the fluid dynamics of the system reveals that both the solutal Marangoni flow inside the drop and the buoyancy-driven flow in the host liquid influence the diffusion-triggered emulsification process. Our work provides a physical understanding of the microdroplet nucleation by dissolution of a multicomponent drop in a host liquid.
Beyond the breaking point? Survey satisficing in conjoint experiments
Authors: Bansak Kirk , Hainmueller Jens , Hopkins Daniel J. , Yamamoto Teppei 
Published: May 2019

AbstractRecent years have seen a renaissance of conjoint survey designs within social science. To date, however, researchers have lacked guidance on how many attributes they can include within conjoint profiles before survey satisficing leads to unacceptable declines in response quality. This paper addresses that question using pre-registered, two-stage experiments examining choices among hypothetical candidates for US Senate or hotel rooms. In each experiment, we use the first stage to identify attributes which are perceived to be uncorrelated with the attribute of interest, so that their effects are not masked by those of the core attributes. In the second stage, we randomly assign respondents to conjoint designs with varying numbers of those filler attributes. We report the results of these experiments implemented via Amazon's Mechanical Turk and Survey Sampling International. They demonstrate that our core quantities of interest are generally stable, with relatively modest increases in survey satisficing when respondents face large numbers of attributes.
Integrated gas field development: The Anjum story
Authors: Hollman F.J. 
Published: May 2019

AbstractIn contrast to oil field development, gas field development requires tight integration of subsurface, surface and economic issues due to the difficulty of storing surplus produced gas and the large effect of the back-pressures in a surface network on the individual well performance. As a major gas supplier the Shell Group, and in particular NAM, has extensive experience in this field.The gas production from onshore fields in the North Friesland area is a recent NAM development. A 10 million cubic meter per day LTS gas treatment installation located near the village of Anjum came on stream in 1997. Production initially started from 3 wells in 2 fields to deliver gas to the Gasunie grid at Grijpskerk. The total area comprises 10 fields and 4 remaining prospects and is planned to be fully developed by the year 2001, using wet gas pipelines to route the production to either the Anjum LTS installation or the Grijpskerk SilicaGel installation.The Rotliegend reservoirs in this part of the Netherlands are very heterogeneous and require a more detailed subsurface simulation than feasible with the standard NAM tool for gas field development (GENREM). In addition, the area is close to the Waddenzee and based on extensive ecological research, NAM uses a stringent, self-imposed ecological constraint, whilst evaluating the development plans for this area. Detailed subsidence studies have been run using subsidence-modeling tools, which run under a software user-interface called FrontEnd, an in-house development by the Shell Group. Also running under this interface is an application for gas field development called Gas Field Planning Tool (GFPT). GFPT combines a detailed subsurface simulator with a surface simulator using a development planning module, which handles economic and operational aspects of the integrated model. Lastly, the interface gives access to a powerful command language and a mathematical toolbox, which can be used to define almost any missing functionality.Making use of the flexibility offered by the FrontEnd interface and with help from available expertise in RTS (Shell Rijswijk), an integrated GFPT model was built, which not only incorporates operational and economic constraints, but also does optimization and subsidence analysis. The model is used to evaluate all development options and scenarios for this area in a consistent manner. Therefore, all proposed development plans are optimized within all applied constraints whether they are related to surface, subsurface, economic, or environmental aspects.Production history and well performance are very close to those predicted by these detailed models, which will allow accurate prediction of future field performance and subsidence.
Subsidence, tremors and society
Authors: Gussinklo H.J. , Haak H.W. , Quadvlieg R.C.H. , Schutjens P.M.F.M. , Vogelaar L. 
Published: May 2019

AbstractThe province of Groningen is flat and level, lying at an elevation close to sea level. The area is intensely cultivated and water table levels are a matter of concern. When the size of the Groningen gasfield was recognized in the sixties, it was realized, that substantial subsidence might occur at the surface affecting a large area.Intensive studies were performed over time to predict future subsidence. These studies are supported by theoretical and experimental research in Shell since the 1950’s concerning reservoir compaction and related surface subsidence. To monitor reservoir compaction and surface subsidence on a regular basis, an extensive monitoring program was set up by NAM. The program comprises leveling surveys, GPS measurements, measurements of shallow formation compaction and in-situ reservoir compaction.In Groningen weak earthquakes have occurred since 1991 at irregular intervals. A multidisciplinary study from 1991–1993 on the relationship between gas production and earthquakes in the northern part of the Netherlands, combined with further studies concluded, that under certain circumstances these earthquakes may result from gas production. Monitoring is carried out through a seismic observation network with borehole sensors and locally installed accelerometers.Because of the expected impact of subsidence induced by gas production on surface water management, an Agreement was concluded between the Province of Groningen and NAM.In line with the 1983 Agreement the ‘Commissie Bodemdaling’ was founded, in which both NAM and the Province of Groningen are represented. On the basis of NAM predictions and actual measurements this Committee determines, what measures are to be taken to prevent, minimize or to correct for effects of gas production induced surface subsidence.
Environmental conditions and paleowind directions at the end of the Weichselian Late Pleniglacial recorded in aeolian sediments and geomorphology (Twente, Eastern Netherlands)
Authors: van Huissteden Ko (J.) , Schwan Jacques C.G. , Bateman Mark D. 
Published: May 2019

AbstractThe Late weichselian Pleniglacial wind regime in the eastern Netherlands is reconstructed by means of landform and sedimentological analysis. This analysis involves aeolian and fluvial landforms in the Dinkel river valley in the Twente region. The aeolian deposits considered here date from the Last Glacial Maximum (approximately 22 ka) to the start of the Belling Interstadial at 14.7 ka.A major event in this period is the formation of a cryoturbation level caused by permafrost degradation, overlain by an erosional hiatus dated between 21 and 17 ka. Both features are attributed to a period of warmer and moister climate, causing permafrost degradation and erosion by surficial runoff. Thereafter aeolian activity prevailed under relatively arid conditions. A deflation surface was formed, the Beuningen Gravel Bed. This deflation surface is present in many Weichselian sections in the Netherlands and the adjacent parts of Belgium and Germany. The deflation occurred concurrently with deposition of coversand at other places.The morphology of the coversand-landscape in the Dinkel valley was controlled by the relief of the pre-existing floodplain and the wind pattern. Coversand ridges consisting of low dunes accumulated near the margins of the active channel belt. Relatively thick sand sheets occur in the leesides of the ridges, thin sand sheets are found at greater distance.Mainly westerly sand-transporting winds operated during winter and summer. In winter aeolian deposition occurred by frequent and strong easterly winds also. On the smallest, local scale, the pattern of deposition was determined by the topography and moisture of the receiving surface.Coversand deposition came to an end with the formation of a sand sheet under relatively warm and less arid conditions. Coversand deposition continued into the Belling Interstadial; colonization of the coversand surface by vegetation probably has been delayed by nutrient-poor conditions.
The climate in The Netherlands during the Younger Dryas and Preboreal: means and extremes obtained with an atmospheric general circulation model
Authors: Renssen H. 
Published: May 2019

AbstractThe shift from the coldYounger Dryas phase to the relatively warm Pre-boreal at~l 1.5 thousand years BP occurred within 50 calendar years and represents a clear example of rapid climate warming. Geologists and palaeo-ecologists have extensively studied the impact of this shift on the environment in The Netherlands. The global atmospheric general circulation model of the Max-Planck-Institute for Meteorology is applied to perform simulations of the Younger Dryas and Pre-boreal climates. Here detailed results are presented for the grid-cell representing The Netherlands, providing quantified estimates of climatic means and extremes for both periods. The results suggest that the Younger Dryas climate was characterised by cold winters (temperatures regularly below -20 °C) and cool summers (13-14 °C), with a high inter-annual variability, strong fluctuations in temperature, frequent storms and snowfall from September to May. The Pre-boreal climate was a ‘continental’ version of present-day climate, with cooler winters, warmer summers (~2 °C difference) and more snowfall, but lower wind speeds. Also, the Pre-boreal climate was wetter than the present and Younger Dryas climates. The main driving factors were the low temperatures of the partly sea-ice covered N Atlantic Ocean and the insolation that was very different from today, with more incoming solar radiation during summer (+30W/m2) and less during winter (-10W/m2).The presented detailed results could be valuable for interpreting palaeo-environmental records and for modelling studies on sedimentological processes during the Late Quaternary.
Vertebrate track bed stratigraphy of the Röt and basal Lower Muschelkalk (Anisian) of Winterswijk (East Netherlands)
Authors: Diedrich C. 
Published: May 2019

AbstractThe 35.5 m thick Anisian section of theWinterswijkse Steen- en Kalkgroeve (Eastern Netherlands) comprises the Upper Röt (Upper Röt Claystone Member) to the basal Lower Muschelkalk (Oolith Member). In the section 15 terrestrial or marine influenced parasequences are recognized. A fourth order sequence shows the increasing marine influence. New marker beds, ten vertebrate track beds, three bone beds and cephalopod remains have been documented. This enabled correlation to other sections in NW Germany. The tracks found in the Winterswijkse Steen- en Kalkgroeve at the boundary Röt/Lower Muschelkalk are linked to the oldest known vertebrate skeleton remains of the Germanic Basin. It is the first time that the exact stratigraphic position of these vertebrate remains has been established. In the terrestrial influenced section of the Winterswijkse Steen- en Kalkgroeve, the well preserved vertebrate track ways and vertebrate fauna will be of international importance and will provide new data of theTriassic carbonate tidal flat megatracksite concept and reptiles living in this environment.
Laser-diffraction and pipette-method grain sizing of Dutch sediments: correlations for fine fractions of marine, fluvial, and loess samples
Authors: Buurman P. , Pape Th. , Reijneveld J.A. , de Jong F. , van Gelder E. 
Published: May 2019

AbstractTo evaluate correlations between silt and clay fractions determined by pipette method and laser diffraction, samples from Dutch fine marine, fluvial, and loess deposits were analysed by both methods. For fluvial deposits, correlations for fractions <2 and >50 μm were excellent (R2 > 0.95), those for 2–4, 4–8, 16–32 and 32–50 μm were satisfactory (R2 = 0.80 – 0.95), while that for the fraction 8–16 μm had an R2 of only 0.68. For marine deposits, correlations for <2 and >50 μm were in the same range, but those of all other fractions except 8–16 μm were lower. In the loess samples, correlations for all but the 8–16 μm fraction were unsatisfactory. Laser diffraction gave 42% of pipette clay in marine samples, and 62% in fluvial and loess samples if regressions are forced through 0. Sand fractions detected by laser diffraction were 107% of the sieve fraction in marine samples, and 99% in the fluvial samples. Correlations for fractions smaller than reference size are generally better than those for individual size fractions. Both the 2 μm and the 50 μm boundary cause problems in the comparison. The first because of platy shape of clay minerals, and the second due to both a change in method in the pipette/sieving procedure, and to non-sphericity of particles. Apparently, correlations for clay- and silt-size fractions obtained by pipette method and laser diffraction will be different for each type of sediment.
Phenotypic plasticity more essential to maintaining variation in host-attachment behaviour than evolutionary trade-offs in a facultatively parasitic mite
Authors: Durkin Emily S. , Luong Lien T. 
Published: May 2019

AbstractA prevailing hypothesis for the evolution of parasitism posits that the fitness benefits gained from parasitic activity results in selection for and fixation of parasitic strategies. Despite the potential fitness advantage of parasitism, facultative parasites continue to exhibit genetic variation in parasitic behaviour in nature. We hypothesized that evolutionary trade-offs associated with parasitic host-attachment behaviour maintain natural variation observed in attachment behaviour. In this study, we used replicate lines of a facultatively parasitic mite, previously selected for increased host-attachment behaviour to test whether increased attachment trades off with mite fecundity and longevity, as well as the phenotypic plasticity of attachment. We also tested for potential correlated changes in mite morphology. To test for context-dependent trade-offs, mite fecundity and longevity were assayed in the presence or absence of a host. Our results show that selected and control mites exhibited similar fecundities, longevities, attachment plasticities and morphologies, which did not provide evidence for life history trade-offs associated with increased attachment. Surprisingly, phenotypic plasticity in attachment was maintained despite directional selection on the trait, which suggests that phenotypic plasticity likely plays an important role in maintaining attachment variation in natural populations of this facultative parasite.
Cytokine profile in first-episode psychosis, unaffected siblings and community-based controls: the effects of familial liability and childhood maltreatment
Authors: Corsi-Zuelli Fabiana , Loureiro Camila Marcelino , Shuhama Rosana , Fachim Helene Aparecida , Menezes Paulo Rossi , Louzada-Junior Paulo , Mondelli Valeria , Del-Ben Cristina Marta 
Published: May 2019

AbstractBackgroundInflammation is a possible biological mechanism underlying the association between childhood maltreatment and psychosis. Previous investigations on this regard were mainly conducted on chronic schizophrenia and lacked control for confounders. We aim to investigate the role of familial liability, childhood maltreatment and recent stress in determining cytokine abnormalities at the onset of psychosis.MethodsWe recruited 114 first-episode psychosis (FEP) patients, 57 unaffected biological siblings of FEP patients, and 251 community-based controls. Plasma cytokines (IL-1β, IL-6, TNF-α, IFN-γ, IL-4, IL-10 and TGF-β) were measured and differences across the groups analysed after adjusting for potential confounders.ResultsFEP had a higher pro- and anti-inflammatory cytokine profile (IL-1β, IL-6, TNF-α, IL-10 and TGF-β), which was not observed in unaffected siblings. Siblings presented decreased IL-1β when compared with patients and controls. Childhood maltreatment was associated with higher levels of TGF-β in both patients and siblings when compared with controls. Physical childhood abuse was associated with increased levels of TGF-β in FEP patients but with decreased levels in controls. Other childhood maltreatment subtypes or recent stressors did not affect cytokine levels in any of the groups.ConclusionsNormal or reduced cytokines in siblings represent possibly a protective factor and suggest that the identified inflammatory profile in FEP can be a real pathophysiological component of psychosis. Experience of childhood maltreatment may contribute as long-term immune priming for the TGF-β pathway, and increased levels of this cytokine in both patients and siblings exposed to childhood maltreatment point to a possible biological candidate of familial risk for psychosis.