bluuebunny/crossref_metadata_2025_split huggingface dataset:
Typing complex meningococcal vaccines to understand diversity and population structure of key vaccine antigens
Authors: Rodrigues Charlene M. C. , Chan Hannah , Vipond Caroline , Jolley Keith , Harrison Odile B. , Wheeler Jun , Whiting Gail , Feavers Ian M. , Maiden Martin C. J. 
Published: November 2018

Background:Protein-conjugate capsular polysaccharide vaccines can potentially control invasive meningococcal disease (IMD) caused by five (A, C, W, X, Y) of the six IMD-associated serogroups. Concerns raised by immunological similarity of the serogroup B capsule, to human neural cell carbohydrates, has meant that ‘serogroup B substitute’ vaccines target more variable subcapsular protein antigens. A successful approach using outer membrane vesicles (OMVs) as major vaccine components had limited strain coverage. In 4CMenB (Bexsero®), recombinant proteins have been added to ameliorate this problem. Methods:Here, scalable, portable, genomic techniques were used to investigate the Bexsero®OMV protein diversity in meningococcal populations. Shotgun proteomics identified 461 proteins in the OMV, defining a complex proteome. Amino acid sequences for the 24 proteins most likely to be involved in cross-protective immune responses were catalogued within thePubMLST.org/neisseriadatabase using a novel OMV peptide Typing (OMVT) scheme.Results:Among these proteins there was variation in the extent of diversity and association with meningococcal lineages, identified as clonal complexes (ccs), ranging from the most conserved peptides (FbpA, NEISp0578, and putative periplasmic protein, NEISp1063) to the most diverse (TbpA, NEISp1690). There were 1752 unique OMVTs identified amongst 2492/3506 isolates examined by whole-genome sequencing (WGS). These OMVTs were grouped into clusters (sharing ≥18 identical OMVT peptides), with 45.3% of isolates assigned to one of 27 OMVT clusters. OMVTs and OMVT clusters were strongly associated with cc, genogroup, and Bexsero®antigen variants, demonstrating that combinations of OMV proteins exist in discrete, non-overlapping combinations associated with genogroup and Bexsero®Antigen Sequence Type. This highly structured population of IMD-associated meningococci is consistent with strain structure models invoking host immune selection.Conclusions:The OMVT scheme facilitates region-specific WGS investigation of meningococcal diversity and is an open-access, portable tool with applications for vaccine development, especially in the choice of antigen combinations, assessment and implementation.
You Can't Have It All: The Experience of Academic Hospitalists During Pregnancy, Parental Leave, and Return to Work
Authors: Gottenborg Emily , Maw Anna , Ngov Li‐Kheng , Burden Marisha , Ponomaryova Anastasiya , Jones Christine D. 
Published: November 2018

BACKGROUNDThe United States lags behind most other countries regarding the support for working mothers and parental leave. Data are limited to describe the experience of female hospital medicine physicians during pregnancy, parental leave, and their return to work in academic hospital medicine.METHODSWe conducted a qualitative descriptive study including interviews with 10 female academic hospitalists chosen from institutions across the country that are represented in Society of Hospital Medicine (SHM) Committees. Interview guides were based on the following domains: experience in pregnancy, parental leave, and return to work. Interviews were recorded, transcribed verbatim, and analyzed using a general inductive approach to theme analysis using the ATLAS.ti software (Scientific Software Development GmbH, Berlin, Germany).PRIMARY OUTCOMEWomen in hospital medicine experience the following six common challenges in their experience as new parents, each of which has the potential to impact their career trajectory, wellness, and are associated with areas for institutional improvement: (1) access to paid parental leave, (2) physical challenges, (3) breastfeeding, (4) career opportunities, (5) colleague responses, and (6) empathy in patient care.
MENINAS E CRIMINALIDADE: UM ESTUDO DE CASO DO CENTRO DE REEDUCAÇÃO SOCIAL SÃO JERÔNIMO (CRSSJ)
Authors: Barreto Ana Flávia Arruda Lanna 
Published: November 2018

Este artigo trata-se de um estudo de caso acerca da criminalidade de adolescentes que cumpriam medidas socioeducativas de internação no Centro de Reeducação Social São Jerônimo (CRSSJ), em Belo Horizonte, Minas Gerais. É descrito a história da unidade, sua estrutura, seus principais objetivos, rotina de atividades e funções do corpo técnico e administrativo. Além disso, são analisadas as dificuldades enfrentadas na unidade socioeducativa, conceitos de violência, principais valores das adolescentes. O estudo sobre a realidade observada nos possibilitou conhecer, mesmo que parcialmente, o universo moral e social das adolescentes em conflito com a lei, seus medos, expectativas e modos de vida que refletem a violência por elas praticada e vivenciada. Percebe-se, a partir da análise de dados qualitativos e quantitativos recolhidos em pesquisa empírica, que as adolescentes são submetidas ao uso indiscriminado da violência, a ausência de mecanismos de sociabilidade e identidade social, a inexistência de valores humanísticos norteadores da formação humana. Essas condições têm levado a ocorrência de ações arbitrárias e criminosas capazes de romper com o humano e valorizar a violência como instrumento de poder, dominação e exclusão.
Prevalencia de lactancia materna en menores de 6 meses en el departamento del Huila, Colombia
Authors: Javela Perez Leonel , Javela Rugeles Julian David , Vallejo Cuellar Lisimaco , Rios Gallardo Angela Magnolia , Reyes Gaspar Pedro Leon , Suaza-Calderón Edilberto , Trujillo Bahamon Claudia Leonor , Alarcón Jose Domingo 
Published: November 2018

Objetivos: conocer la prevalencia de lactancia materna (exclusiva, predominante y con alimentación complementaria) en bebés <6 meses en el Huila y subregiones, así como factores relacionados.Métodos: estudio con diseño correlacional, descriptivo-transversal, en madres de bebés <6 meses realizado entre octubre-diciembre de 2015. Del total de bebés <6 meses del Huila (N=755), se realizó una encuesta a madres de 335 bebés, incluyendo los 37 municipios, el árearural y urbana. Se realizó muestreo no probabilístico por conveniencia utilizando información del Instituto Colombiano de Bienestar Familiar, centros asistenciales en salud y búsqueda aleatorizada simple para ubicar a las madres.Resultados: en <6 meses se encontró prevalencia de lactancia materna del 95.8 %; lactancia materna exclusiva obtuvo 58.5 %; predominante, 17.6 %; y alimentación complementaria a lactancia materna 19.7%. Categorizando por grupos etarios (meses de 0-1, 2-3 y 4-5), la prevalencia de la lactancia materna exclusiva fue 74.8, 56.4 y 31.3 %, respectivamente. Al sumar la lactancia materna exclusiva con la predominante (lactancia materna completa), las prevalencias fueron 85.3, 72.2 y 63.8 %, respectivamente.Conclusiones: se logró conocer por primera vez para el departamento del Huila las prevalencias en lactancia materna. La prevalencia de lactancia materna, lactancia materna exclusiva, predominante y con alimentación complementaria, tanto en total de <6 meses, categorizando por subgrupos etarios, es mayor que la media referida para Colombia en su Encuesta Nacional de Situación Nutricional (Ensin-2010). Se logró establecer indicadores para subregiones del Huila y caracterización de factores relacionados con lactancia materna.
Halal Meat Supply Chain Traceability based on HACCP, Blockchain and Internet of Things
Authors: Rejeb Abderahman 
Published: November 2018

Recently, Halal food has drawn remarkable attention of many consumers around the world. Besides to being unsafe, Halal food such as meat can encounter several issues throughout its supply chain and logistics. At any time, Halal integrity is not guaranteed and risks of becoming non-Halal is the major concern of all parties along the supply chain. To respond to Muslim consumers’ trust concerns in Halal food, many traceability systems were proposed in previous studies based on emerging technologies and recommended to be incorporated into Halal food supply chains. Nevertheless, all of these systems are centralized, opaque and not enough transparent. To mitigate these problems, blockchain technology is introduced as a ground-breaking innovation with greater decentralization, visibility and transparency. This paper makes a major contribution in suggesting Halal meat supply chain traceability system for real-time food tracing based on embedding Islamic dietary law into HACCP, blockchain and Internet of Things.
Histories of Futures Past: Dystopian Fiction and the Historical Impulse
Authors: Heise-von der Lippe Anya 
Published: November 2018

AbstractThis article traces the historical impulse in two intertextually connected dystopian texts – George Orwell’s1984(1949) and Margaret Atwood’sThe Handmaid’s Tale(1985) – by reading the two novels in the context of the construction of historical narrative after the proclaimed ‘end of history’ in the twentieth century. It considers their representation of history within the framework of literary criticism of the historical novel (György Lukács), critical dystopias (Tom Moylan), and memory as an active, mediated engagement with the past (Astrid Erll and Ann Rigney). It looks, more specifically, at how the texts contrast personal experience and the meta-narrative contemplation of memory with institutionalized versions of history on different diegetic levels by juxtaposing the narrators’/focalizers’ view of history with that presented in the framework of pseudo-historical appendices that accompany and significantly modify the interpretations of both narratives.
Kualitas Sumur Gali di Dusun Wahakaim
Authors: Souisa Gracia Victoria , Y. Janwarin Lea Mediatrix 
Published: November 2018

Abstrak
Seluruh kepala keluarga Dusun Wahakaim, Desa Aketernate, memenuhi kebutuhan air bersih dengan mengandalkan sumur gali yang secara fisik tidak memenuhi syarat kualitas air bersih. Penelitian ini bertujuan, mengetahui gambaran kualitas air sumur gali ditinjau dari parameter fisik, kimia dan mikrobiologi sebelum dan sesudah penyaringan sederhana. Desain penelitian yang digunakan adalah survey deskriptif berbasis laboratorium, dengan total sampel sebanyak 12 sampel air. Pemeriksaan kualitas air dilakukan di Laboratorium Kesehatan, Provinsi Maluku, data hasil laboratorium secara deskriptif dibandingkan dengan Permenkes RI Nomor 416/Menkes/Per/IX/1990. Hasil penelitian menunjukan, untuk sampel air yang belum disaring, sebanyak 3 sumur gali (37,5%) tidak memenuhi syarat TDS dan rasa, sebanyak 7 sumur gali (87,5%) tidak memenuhi syarat mangan dan klorida, dan 100% tidak memenuhi syarat Total coli, sedangkan sebanyak 4 sumur gali (50%) tidak memenuhi syarat E.coli dan untuk sampel air yang telah disaring, sebanyak 2 sampel air (50%) tidak memenuhi syarat TDS, sedangkan parameter mikrobiologi sebanyak 3 sampel air (75%) tidak memenuhi syarat Total coli. Efektifitas penyaringan sederhana optimal pada parameter kekeruhan, TSS dan mangan.

Abstract
All of the family heads of Wahakaim, Aketernate Village, met the need for clean water by relying on dug wells that did not physically meet the requirements of clean water quality. This study aims to find out the description of the water quality of dug wells in terms of physical, chemical and microbiological parameters before and after simple filtering. The research design used was a laboratory-based descriptive survey, with a total sample of 12 water samples. Water quality checks were carried out in the Health Laboratory, Maluku Province, descriptive laboratory data compared to Permenkes RI Number 416 / Menkes / Per / IX / 1990. The results showed that for the water samples that had not been filtered, 3 dug wells (37.5%) did not meet the TDS and taste requirements, as many as 7 dug wells (87.5%) did not meet the requirements of manganese and chloride, and 100% did not meet Total coli requirements, while as many as 4 wells dug (50%) did not meet E.coli requirements and for water samples that were filtered, 2 water samples (50%) did not meet the TDS requirements, while microbiological parameters were 3 water samples (75% ) does not meet the requirements of Total coli. Simple optimal filtering effectiveness on turbidity parameters, TSS and manganese.
Kebiasaan Sarapan pada Mahasiswa Aktif
Authors: Putra Alman , Syafira Dhea Nur , Maulyda Salma , Cahyati Widya Hary 
Published: November 2018

Abstrak
Di Provinsi Jawa Tengah terdapat status gizi kurang sebanyak 7,5 %, status gizi normal sebanyak 53,1 %, status gizi gemuk sebanyak 28,1, dan status gizi obes sebanyak 11,2 %. Asupan salah satu faktor yang mempengaruhi status gizi. Asupan salah satunya dapat dipenuhi dengan sarapan. Dalam penelitian ini menggunakan sampel Mahasiswa Semester 1-7 Program Studi Kesehatan Masyarakat Universitas Ngudi Waluyo yang berjumlah 77 orang. Jenis penelitian yang digunakan adalah penelitian yang bersifat deskriptif kualitatif dengan desain penelitian cross sectional. Dari hasil penelitian, dapat diketahui bahwa secara keseluruhan Mahasiswa Pogram Studi Kesehatan Masyarakat memiliki status gizi normal sebanyak 57 responden (74 %). Kebiasaan sarapan terdapat lebih banyak frekuensi sarapan responden 43 (56 %) jarang melakukan sarapan. Lebih banyak 64 responden (83 %) melakukan sarapan sebelum pukul 09.00. Sedangkan responden melakukan sarapan setiap pagi sebanyak 38 (49 %) hampir sama dengan responden melakukan sarapan hanya saat sebelum melakukan aktivitas sebanyak 39 (51 %).

Abstract
In Central Java Province, there are less than 7.5% nutrition status, 53.1% normal nutrition status, 28.1 obese nutrition status, and obesity nutrition status of 11.2%. Intake of one of the factors that affect nutritional status. One intake can be filled with breakfast. In this study used a sample of Students Semester 1-7 Ngudi Waluyo Community Health Studies Program which amounted to 77 people. The type of research used is descriptive qualitative research with cross sectional research design. From the results of the research, it can be seen that overall Student Pogram Studies Public Health has normal nutritional status as much as 57 respondents (74%). Breakfast habits are more frequent breakfast 43 respondents (56%) rarely do breakfast. More 64 respondents (83%) did breakfast before 09.00. While respondents do breakfast every morning as much as 38 (49%) almost the same as the respondent to do breakfast just before the activity as much as 39 (51%).
Artocarpus altilis Extracts as Liquid Electric Mosquito Repellent Against Aedes aegypti
Authors: Ernawati Ernawati , Cahyati Widya Hary 
Published: November 2018

ABSTRACT
Aedes aegypti is the main vector of dengue virus carriers. One alternative to deal with these problem is by using insecticides derived from the leaves of breadfruit (Artocarous altilis) with the method of liquid electric. The research was purely experimental, with a posttest-only control group design with six variations of extract concentration of 9%, 13%, 20%, 30%, 44%, and 66% with 3 repetitions. The result of Kruskal Wallis test showed that there was a difference of the average number of Aedes aegypti mosquito mortality on various concentration of breadfruit leaf extract, that indicated by significance or probability value of 0.008 <0.05. The deadliest concentration of breadfruit leaf was 66% concentration with mosquito mortality of 83.3% from all mosquito test. The probit analysis obtained LC50 at concentration of 17.850% and LC90 at concentration of 98.348%.

Keywords: Aedes aegypti, Breadfruit Leaf Extract, Liquid Electric

ABSTRAK
Aedes aegypti merupakan nyamuk yang menjadi vektor utama pembawa virus dengue. Salah satu alternatif lain untuk menangani permasalahan tersebut yaitu dengan menggunakan insektisida yang berasal dari tumbuhan atau nabati, yaitu daun sukun (Artocarous altilis) dengan metode elektrik cair. Jenis penelitian ini adalah eksperimen murni, dengan rancangan posttest only control group design dengan enam variasi konsentrasi ekstrak sebesar 9%, 13%, 20%, 30%, 44%, dan 66% dengan masing-masing 3 kali pengulangan. Hasil uji Kruskal Wallis menunjukkan bahwa ada perbedaan rata-rata jumlah kematian nyamuk Aedes aegypti pada berbagai konsentrasi ekstrak daun sukun, ditunjukkan dengan nilai signifikansi atau probabilitas adalah 0,008 < 0,05. Konsentrasi ekstrak daun sukun yang paling banyak mematikan nyamuk yaitu konsentrasi 66% dengan kematian nyamuk 83,3 % dari keseluruhan nyamuk. Uji analisis probit didapatkan LC50 pada konsentrasi 17.850% dan LC90 pada konsentrasi 98.348%.

Kata kunci: Aedes aegypti, Ekstrak Daun Sukun, Elektrik Cair
Risk Factors of Autism Spectrum Disorder (ASD)
Authors: Hernawan Andri Dwi , Diningrum Aisyah , Jati Sri Nugroho , Nasip M. 
Published: November 2018

Abstract
There were 112,000 ASD sufferers in Indonesia in 2012 and in 2015 it was estimated that there were 1 per 250 children or 134,000 sufferers. The proportion of ASD was 62.8% and in 2016 it was 1.28 out of 1000 children in 2015. This study aimed to determine the risk factors for the incidence of ASD in Pontianak City. The research method was analytic observational with a control case study design. The sample was 70 people (35 cases and 35 controls) taken by purposive sampling technique. Data analysis used Chi-Square test (α = 0,05). The results showed that the factors associated with the incidence of ASD were father's age (p = 0.03; OR = 4.00; CI = 1.250-12.804), stress history during pregnancy (p = 0.04; OR = 3.18; CI = 1.13-8.93) and insufficient months of birth (p = 0.036; OR = 4.88; CI = 1.22-19.4), while age of mother during pregnancy, passive smoker, antenatal hemorrhage and pregnancy interval were not associated with the incidence of ASD (p> 0.05). The conclusion of this study is father's age, the presence of a history of stress during pregnancy and insufficient months of birth associated with the incidence of ASD.
Keywords: Father’s age, Stress History, Autism Spectrum Disorder

Abstrak
Autism Spectrum Disorder (ASD) dikenal sebagai triad of impairments yaitu adanya gangguan perkembangan pada aspek komunikasi, adanya perilaku yang diulang-ulang dan gangguan dalam berinteraksi dengan lingkungan. Pada tahun 2012 dilaporkan sebanyak 112.000 penderita ASD di Indonesia, tahun 2015 diperkirakan terdapat 1 per 250 anak atau 134.000 penderita. Data dari UPTD Autis Center Kota Pontianak tahun 2015 proporsi ASD sebesar 62,8% dan pada tahun 2016 sebesar 1,28 dari 1000 anak. Penelitian ini bertujuan untuk mengetahui faktor risiko kejadian ASD di Kota Pontianak. Metode penelitian adalah observasional analitik dengan desain studi kasus kontrol.Sampel penelitian berjumlah 70 orang (35 kasus dan 35 kontrol) yang diambil dengan teknik purposive sampling. Analisis data menggunakan uji Chi-Square (α=0,05). Hasil penelitian menunjukkan faktor yang berhubungan dengan kejadian ASD adalah usia ayah (p=0,03; OR=4,00; CI=1,250-12,804), riwayat stres saat hamil (p=0,04; OR=3,18; CI=1,13-8,93) dan lahir belum cukup bulan (p=0,036; OR=4,88; CI=1,22-19,4), sedangkan usia ibu saat hamil, perokok pasif, perdarahan antenatal dan jarak kehamilan tidak berhubungan dengan kejadian ASD (p>0,05). Simpulan penelitian ini adalah faktor usia ayah, adanya riwayat stres saat hamil dan kelahiran belum cukup bulan berhubungan dengan kejadian ASD.
Keyword : Usia ayah, riwayat stress, Autism Spectrum Disorder
Renal cell carcinoma: a systematic review and meta-analysis on expression of androgen receptor
Authors: Abdi Hossein , Reza Mozaffari Hamid , Payandeh Mehrdad , Sadeghi Edris 
Published: November 2018

Background: Chromosome Xq11-12 is the place that the androgen receptor (AR) sequence appears. Herein, the prevalence of this biomarker and its relation with pT stage and tumor grade was reported.
Methods: Four online sites (PubMed, Scopus, Web of Science, and Cochrane Library) have been searched up to Sep 2018 systematically. Meta-Analysis software version 2.0 (CMA 2.0) and STATA 14.0 statistical software were utilized. Publication bias did not exist.
Results: From the initial 1141 articles identified from the systematically searches. At last, nine of them remained for analysis. The meta-analysis included 1447 patients that 345 of them had AR expression. AR expression significantly correlated with low tumor grade and low tumor pT stage.
Conclusion: AR expression was 28.2%, and it had the relationship with tumor low grade and low pT stage. Additional studies required to figure out the role of it on RCC patients.
Investigating cell blood counter and abdominal radiography accuracy in diagnosis of acute suppurative appendicitis among patients under surgery
Authors: Shahmoradi Mohammad Kazem , Mahmoudvand Hormoz , Nadri Sedigheh , Niazi Massumeh , Adeli Mahin , Rouientan Abdolreza 
Published: November 2018

Background: Acute appendicitis is the most common surgical emergencies; while unusual symptoms have a differential diagnosis. This study aimed to determine the diagnostic accuracy of CBC and abdominal X-ray in acute suppurative appendicitis.
Methods: This cross-sectional study was performed on 198 patients. For all patients, complete blood count and abdominal X-ray were recorded. The pathological report after surgery was the gold standard for diagnosis. Then indicators of the validity of tests CBC, X-ray and neutrophil to lymphocyte ratio, consisted of positive predictive value (PPV) and negative predictive value (NPV), sensitivity, specificity, were analyzed.
Results: Out of patients, 133 of patients were male (67.2%), and 65 (32.8%) were female with mean age of 29.13 years. Acute appendicitis confirmed in 77.8% of pathological study, and 17.7% was the normal appendix. Leukocytosis, NLR and abdominal X-ray tests, each have a sensitivity of 89.5%, 78.5% and 100%, specificity of 31.4%, 31.4% and 31.8%, PPV 85.8%, 84.2% and 53.9%, NPV 39.2%, 23.9% and 100%, respectively. There was a significant relationship between appendicitis and WBC> 10.000 and abdominal radiography findings.
Conclusion: Due to the sensitivity of performing CBC and leukocytosis and NLR is at an acceptable level, especially with a relatively high positive predictive value, could be concluded that the positivity of these tests for confirming the diagnosis in suspected cases might be helpful and can help to strengthen the clinical diagnosis. Our results in relation to the x-ray of the abdomen suggest its usefulness in the diagnosis of appendicitis.
Первая находка гриба Diaporthe phaseolorum на подсолнечнике в России
Authors: Гомжина М. М. , Ганнибал Ф. Б. 
Published: November 2018

Грибы рода Diaporthe широко распространены по всему миру, многие виды являются патогенами экономически значи-мых культур, в том числе и подсолнечника. Традиционно идентификацию видов Diaporthe осуществляли по морфологическим, морфолого-культуральным признакам и связи с питающим растением. Достоверную идентификацию до уровня вида представителей этого рода на настоящий момент рекомендуется осуществлять, основываясь на изучении молекулярно-генетических признаков. Комплексное изучение видов Diaporthe в России с применением методов молекулярной филогении не проводилось.
Представленная работа посвящена идентификации изолята Diaporthe sp., выделенного из подсолнечника, собранно-го в Краснодарском крае. Согласно полученным результатам изучения молекулярно-генетических (нуклеотидные последовательности области внутренних транскрибируемых спейсеров рибосомальной ДНК, генов β-тубулина и фактора элонгации трансляции-1α) и морфологических признаков, изолят MF 16-010 был идентифицирован как вид Diaporthe phaseolorum (Cooke & Ellis) Sacc. На территории России этот изолят является первой достоверной находкой данного вида на подсолнечнике. В результате искусственной инокуляции было показано, что изолят MF 16-010 является для подсолнечника патогенным.