bluuebunny/crossref_metadata_2025_split huggingface dataset:
Experiencia con paratiroidectomía quirúrgica en pacientes con enfermedad renal crónica e hiperparatiroidismo terciario
Authors: Sanint Valentina , Restrepo Valencia César Augusto , Chala Galindo Andrés Ignacio 
Published: September 2019

Introducción: el hiperparatiroidismo terciario es la consecuencia final de las alteraciones del metabolismo calcio-fósforo en pacientes con enfermedad renal crónica. Aquellos pacientes que no logran controlarlo con el tratamiento médico, requieren paratiroidectomía.
Objetivo: describir la evolución clínica y paraclínica en pacientes con enfermedad renal crónica y diagnóstico de hiperparatiroidismo terciario, que fueron llevados a paratiroidectomía.
Metodología: estudio prospectivo, que incluyó pacientes con hiperparatiroidismo terciario llevados a paratiroidectomía entre los años 2006 y 2015. Se realizaron estudios bioquímicos pre y post quirúrgicos y se evaluó la presencia y progresión de síntomas.
Resultados: se incluyeron 32 pacientes, 68.8% mujeres, con media de edad de 46.2 años. Se identificaron diferencias estadísticamente significativas en el cambio en los valores de calcio, fósforo y PTH pre y post quirúrgicos. El 81.5% de los pacientes reportaron presencia de síntomas. El 34.6, 26.9, y 23% presentaron mejoría total de dolor óseo, dolor articular y prurito, respectivamente. El 28% presentaron hipocalcemia sintomática post operatoria. No hubo casos de muerte durante el seguimiento.
Conclusiones: la paratiroidectomía se constituye en un alternativa segura y confiable para los pacientes con hiperparatiroidismo terciario, mejorando significativamente los síntomas y las alteraciones en el metabolismo óseo y mineral. Vigilar los niveles de calcio en el post operatorio es importante para evitar las complicaciones del síndrome de hueso hambriento
Patrones de prescripción de medicamentos antitiroideos en una población de Colombia
Authors: Machado-Alba Jorge Enrique , Medina-Morales Diego Alejandro , Valladales-Restrepo Luis Fernando , Loaiza-Bedoya Daniel , Paredes-Mendoza Milton 
Published: September 2019

Introducción: En Colombia no se conoce la prevalencia de los trastornos asociados a tirotoxicosis ni se dispone de estudios fármacoepidemiológicos acerca de la prescripción de los medicamentos antitiroideos.
Objetivo: Determinar los patrones de prescripción de los antitiroideos y variables asociadas a su uso en una población de pacientes Colombia.
Métodos: Estudio de corte transversal, realizado entre enero 1 y marzo 30 de 2015 sobre los hábitos de prescripción de medicamentos antitiroideos en una población afiliada al Sistema de Salud Colombiano. Se midieron variables sociodemográficas, farmacológicas y de comedicación. Se diseñó una base de datos sobre el consumo de medicamentos y se utilizaron pruebas t de Student, X2 y modelos de regresión logística.
Resultados: Un total de 327 pacientes en tratamiento con medicamentos antitiroideos fueron incluidos. La edad media fue de 53,7±18,1 años y el 78,3% de pacientes correspondió a mujeres. El metimazol se prescribió en el 95,4% de los pacientes, el propiltiouracilo en el 4,6%. En el 76,8% de pacientes se presentó comedicación; en particular con antihipertensivos (38,2%) y adicionalmente con propranolol (34,3%).
Conclusiones: La tendencia de prescripción de medicamentos antitiroideos en Colombia es similar a lo reportado en diferentes estudios a nivel mundial. El principal medicamento antitiroideo es metimazol, con una tasa de uso mayor a la reportada en Norteamérica y en estudios europeos. Las dosis del metimazol y de propiltiouracilo reportadas en este estudio se ajustan a las recomendaciones de la Asociación Americana de Endocrinología Clínica.
Reporte de casos
Authors: Méndez-Álvarez Lupo , Albino-Serpa Fiorella , Donado-Gómez Jorge Hernando 
Published: September 2019

Un reporte de caso es un tipo de estudio observacional que presenta detalladamente problemas médicos de un paciente único y de características únicas. Organizan y vuelven a narrar lo que ocurrió en la historia clínica, evolución de la enfermedad, cuidados médicos instituidos y los resultados obtenidos. Son el único medio para describir eventos clínicos raros. Si bien son el nivel de evidencia más bajo, se consideran como la primera línea de evidencia. Dentro de los reportes de casos se identifican dos tipos, unos relacionados al diagnóstico, en los cuales se aborda una condición clínica nueva o presentación inusual de una enfermedad conocida. Y otro tipo, los relacionados al tratamiento donde se evidencia un enfoque terapéutico nuevo, original o mejor y la aparición de nuevos o inusuales efectos adversos. Además, estos reportes pueden ilustrar un nuevo principio, apoyar o refutar una teoría actual y así estimular la investigación. En este artículo brindamos herramientas para este fin.
Incluimos información referente a aspectos éticos, listado de revistas especializadas en publicación de reportes de casos y cómo ha sido la evolución de la publicación de los reportes de casos a lo largo del tiempo. Se hace necesaria esta información para brindar al personal en formación o con poca experiencia en el tema, cuáles son las condiciones que ameritan escribir un reporte de casos y en caso de llegar a requerirlo cómo se debería escribir de una adecuada forma.
ISLAMISASI DI KAWASAN LAUT SULAWESI PADA ABAD KE-19
Authors: Ichsan Azis Muhammad Nur 
Published: September 2019

Islamisasi yang terjadi di Nusantara pada abad ke-19 tidak terlepas dari peran dan pengaruh para pedagang sekaligus ulama dari Timur Tengah yang membawa ajaran Islam. Proses Islamisasi dan konversi agama membutuhkan waktu dan proses panjang, hingga sampai diterima oleh masyarakat setempat. Penerimaan ajaran Islam dilakukan melalui beberapa saluran, terutama dalam jaringan perdagangan. Kawasan Laut Sulawesi, sebagai entrepot, merupakan salah satu jalur Islamisasi karena perkembangan perdagangan rempah-rempah di Maluku sebagai wilayah penghasil rempah-rempah.Tulisan ini bertujuan mengungkap proses Islamisasi di sekitar Kawasan Laut Sulawesi pada abad XIX.Tulisan ini merupakan tulisan sejarah, dengan menggunakan metode sejarah; heuristik, kritik, interpretasi, dan historiografi yang bersifat analisis-kualitatif dan mampu menunjukkan satu rangkaian proses Islamisasi yang terjadi di Nusantara sekitar abad XIX. Hasil kajian ini menunjukkan bahwa pengaruh Islam diawali dari proses perdagangan, di kawasan Laut Sulawesi, bagi pedagang yang menghubungkan ke Maluku sebagai satu pola Islamisasi, sehingga di masa berikutnya komunitas Muslim mampu menciptakan Moslemen clave di Semenanjung Laut Sulawesi.
RINTISAN AWAL PENDIDIKAN MUHAMMADIYAH DI SUMATERA BARAT TAHUN 1925-1939
Authors: Rohman Fandy Aprianto , Mulyati Mulyati 
Published: September 2019

Muhammadiyah pada awalnya hanya berkembang di wilayah Pulau Jawa saja, namun dalam waktu cepat dapat menyebar ke seluruh Indonesia, termasuk ke Sumatera Barat. Pada tahun 1925, Syekh Abdul Karim Amrullah membawa perserikatan ini ke Sumatera, tepatnya di Maninjau, Sungai Batang, Sumatera Barat. Dari sinilah Muhammadiyah semakin berkembang ke seluruh Sumatera. Penelitian ini menganalisis dan mendeskripsikan proses awal mula Muhammadiyah muncul di Sumatera Barat hingga usaha-usaha yang dilakukan Muhammadiyah untuk mengembangkan gagasan pembaruan. Adapun penelitian ini menggunakan teknik analisa kualitatif, yaitu analisa yang didasarkan pada hubungan sebab-akibat dari fenomena historis pada cakupan waktu dan tempat. Hasil penelitian menunjukkan bahwa daya tarik Muhammadiyah di Sumatera Barat terletak pada gerakan pemurnian Islam, terutama dalam bidang pendidikan. Muhammadiyah memperbarui sistem pendidikan Islam di Sumatera Barat dengan tujuan mendidik masyarakat agar menghindari hal-hal yang bertentangan dan menyimpang dari akidah Islam. Muhamadiyah initially only developed in the island of Java, but soon it could spread throughout Indonesia, including West Sumatera. In 1925, Syekh Abdul Karim Amrullah brought this organization to sumatera, precisely in Maninjau, Sungai Batang, West Sumatera. From this, Muhammadiyah increasingly developed throughout Sumatera. This study analyzes and describes the initial process of Muhammadiyah appearing in West Sumatera until the efforts made by Muhammadiyah to develop renewal ideas. The research uses qualitative analysis techniques, namely analysis based on causal relationship of historical phenomena in the scope of time and place. The result of the study indicate that the appeal of Muhammadiyah in West Sumatera lies in the Islamic purification movement, especially in the field of education. Muhammadiyah renewed the Islamic education system in West Sumatera with the aim of educating the public to avoid things that are contrary and deviate from the Islamic faith.
REFLEKSI NILAI BUDAYA DALAM UNGKAPAN TRADISIONAL MASYARAKAT LUBUKLINGGAU SUMATERA SELATAN
Authors: Hasanadi Hasanadi 
Published: September 2019

This research investigates cultural values reflection existing within Lubuklinggau community in South Sumatera Province through several of traditional expressions. They are: 1) Expression of payu ponga nilek ngelup. Jengan melawan wang tue nilek meresak; (2) Expression of awak tue betunak dǝak hiyang melam kire nak ngelong; (3) Expression of lah ngidar lah baputar lom dǝpat jelan hatuju; (4) Expression of makan ati nenggung sedingan rube abis resan urung; (5) Expression of lambat bekat gǝcang dǝpat. By using literary sociological approach and reinforced by hermeneutic analysis, it was concluded the five expressions reflect the cultural values of Lubuklinggau community, especially related to several life aspect, namely: (1) The need for a perennial commitment to be consistent and obedient to parents; (2) The importance of wife presence as a life partner and the significance of maintaining the integrity of family; (3) The need for knowledge in understanding the dynamics of dialogue that arises within community; (4) The need to compromise in maintaining friendship and healthy relationship amidst citizens; and (5) The importance of accurateness as well as swiftness in every field of engaged business.Keywords: cultural values reflections, traditional expressions, Lubuklinggau
FUNGSI DAN PELESTARIAN ALAT MUSIK SUNAI DI KABUPATEN MUKOMUKO PROPINSI BENGKULU
Authors: Arios Rois Leonard 
Published: September 2019

Sunai merupakan alat musik utama pengiring tari gandai. Dalam mitologi suku bangsa Pekal mengenal tokoh Malin Deman yang menciptakan sunai untuk mengiringi tari gandai yang ditarikan oleh dayang-dayang. Walaupun berasal dari suku bangsa Pekal, masyarakat Kabupaten Mukomuko yang multi etnis menjadikan alat musik sunai sebagai bagian dari kesenian mereka. Pertanyaannya adalah bagaimana fungsi sunai bagi masyarakat dan upaya pelestariannya hingga tetap eksis. Penelitian dilakukan dengan pendekatan kualitatif dengan wawancara, pengamatan, dan studi pustaka sebagai alat pengumpul data. Hasil penelitian menggambarkan bahwa sunai menjadi pemersatu masyarakat yang beraneka ragam budaya dan menjadi milik bersama masyarakat Kabupaten Mukomuko. Hal ini terlihat dari semakin banyaknya pemain sunai dan tampil mengiringi tari gandai. Pemerintah Kabupaten Mukomuko juga melakukan berbagai kegiatan agar sunai semakin dikenal oleh masyarakat.
EFEKTIVITAS PENGGUNAAN PENDEKATAN PEMBELAJARAN REALISTIC MATHEMATIC EDUCATION (RME) DENGAN BERBANTUAN MEDIA PEMBELAJARAN APLIKASI KAHOOT
Authors: Wijayanti Rica , HERMANTO DIDIK , ZAINUDDIN ZAINUDDIN 
Published: September 2019

Rancangan yang dibuat oleh seorang guru sangat menentukan terhadap keberhasilan belajar siswa. Namun, permasalahan yang sering terjadi di lapangan adalah tidak semua guru mampu mendesain proses pembelajaran dengan tepat. Salah satu desain yang dapat digunakan oleh seorang guru ketika mengajar adalah menggunakan pendekatan pembelajaran sesuai dengan mata pelajaran yang akan diajarkan. Pendekatan Realistic Mathematic Education (RME) adalah sebuah pendekatan yang dapat menjadi alternatif untuk digunakan ketika mengajarkan mata pelajaran matematika. Pendekatan ini mengaitkan matematika dengan kehidupan nyata siswa sehingga siswa dapat langsung menerapkan ilmu yang diperoleh. Selain menggunakan pendekatan, guru juga harus mendesain media pembelajaran. Media pembelajaran kahoot adalah media berupa game edukasi yang memanfaatkan teknologi berbasis android. Tujuan penelitian ini adalah untuk mendeskripsikan keefektivan dari pendekatan Realistic Mathematic Education (RME) dengan berbantuan media pembelajaran aplikasi kahoot. Jenis penelitian yang digunakan dalam penelitian ini adalah penelitian quasi eksperiment (eksperimen semu). Hasil data yang diperoleh pada penelitian ini menunjukkan bahwa sebesar 8,46 dan sebesar 2,07. Karena , maka dapat disimpulkan bahwa diterima dan ditolak. Artinya, pendekatan Realistic Mathematic Education (RME) dengan berbantuan media pembelajaran aplikasi kahoot efektif digunakanKata Kunci : Efektivitas; Pendekatan RME; Media pembelajaran kahoot;
Content and language integrated learning and teaching in digital class: Latvia experience
Authors:   University of Latvia, Latvia, Anspoka Zenta , Eglite Inese 
Published: September 2019

The topicality of the research relates to the problem that in the last ten or more years approximately 300 thousand Latvian people live outside Latvia. Together with parents are living children in more than 15 countries. One of the tasks with national importance is to help to children and their family to save or to develop Latvian language and culture traditions, to give possibility to return to Latvia and to continue education process in Latvia. Latvian Language State Agency provides an opportunity to learn Latvian as a State language and to get acquainted	with Latvian culture traditions, to understand social events, relationships in the society. One of possibility for this is to plan and to realize integrated content and language learning and teaching process for children outside Latvia in a digital class. That means to use Classflow site and another digital tools (Skype, a mobile phone and toys with special computer software, interactive blackboard programs etc.). Aim of the study is to analyze the experience of children living outside Latvia to learn integrated content and language with digital tools. Research is based on analyses of theories about content and language integrated learning, communicative approach for language acquirement and teacher’s professional competence. Empirical research is based on pedagogical observation and teacher’s survey results. As respondents are 120 children (6-14 year old) in 22 groups/digital classes and 16 teachers./ Keywords: digital class as a work organization form, content and language integrated learning (CLIL), teacher’s professional competence
Investigação quanto aos índices de conforto térmico em uma indústria de sorvetes
Authors: Terra Stela Xavier , Ferreira Jessica Rodrigues Paiva , Campos Larissa Baladam , Coelho Mariana Matos , Franz Luis Antonio Dos Santos 
Published: September 2019

O presente trabalho realizou um estudo de caso em uma empresa familiar de pequeno porte da indústria de alimentos no setor de produção de uma empresa de pizzas e sorvetes. O objetivo deste estudo é de aplicar os conceitos de conforto térmico identificando melhorias nas condições de conforto térmico no ambiente de trabalho para os colaboradores. Para tal, foi realizada uma pesquisa de campo para coleta de dados sobre o conforto térmico por meio da realização de leituras para temperaturas através do medidor de stress térmico TGD-200, durante quase duas horas em intervalos de 10 minutos. Após feita a coleta, os dados foram utilizados em uma ferramenta online com o propósito de calcular índices de conforto térmico e foi gerado um gráfico para análise. Com os resultados foi constatado que ao longo de algum tempo há sensação térmica levemente fria no ambiente para o posto de trabalho analisado e isso faz com que haja perda de capacidade na eficiência de trabalho podendo até gerar riscos ocupacionais como doenças de frio. Assim esse estudo propõe algumas medidas para melhorar o conforto térmico dos ocupantes do posto de trabalho no ambiente de produção de sorvetes.
Custos logísticos no canal reverso: estudo de caso da polpa de açaí na cidade de Castanhal-PA
Authors: Neto Marco Aurélio Gouveia Furtado Belém , Nunes Denilson Ricardo de Lucena , Santos Lucas de Oliveira , Silva André Cristiano 
Published: September 2019

O açaí, fruto típico da região amazônica, vem apresentando uma crescente no seu consumo em âmbito global, tal fato culmina, consequentemente, no aumento da geração de uma grande quantidade de resíduo que, caso não seja reaproveitado, será destinado aos lixões. A Política Nacional de Resíduos Sólidos surgiu para orientar a gestão de resíduos sólidos, com destaque para a estruturação de canais logísticos reversos, onde ocorre grande parte dessa gestão. Os processos logísticos que ocorrem nos canais reversos geram custos. Sabe-se que ao alocar esses custos de maneira correta, o canal logístico tende a se fortalecer e se perpetuar. Frente ao exposto, este estudo consistiu em estimar os custos logísticos referentes aos canais reversos do resíduo do açaí na cidade de Castanhal-PA, além disso, foi necessário avaliar a forma de custeio mais adequada pra esse caso. O estudo foi realizado em 4 etapas, afim de fazer com que houvesse uma melhor divisão das etapas teóricas e práticas, foram elas: identificação dos agentes nos canais, processos que ocorrem nos canais e levantamento bibliográfico sobre custeio e custeio logístico. Observou-se que o sistema ABC se mostrou mais compatível para esse tipo de custeio em virtude do nível de complexidade e necessidade de informações. Esse sistema foi usado para estimar os custos logísticos nas atividades de coleta e distribuição dos resíduos da polpa do açaí.
BTLA–HVEM Checkpoint Axis Regulates Hepatic Homeostasis and Inflammation in a ConA-Induced Hepatitis Model in Zebrafish
Authors: Shi Wei , Shao Tong , Li Jiang-yuan , Fan Dong-dong , Lin Ai-fu , Xiang Li-xin , Shao Jian-zhong 
Published: September 2019

Abstract
The BTLA−HVEM checkpoint axis plays extensive roles in immunomodulation and diseases, including cancer and autoimmune disorders. However, the functions of this checkpoint axis in hepatitis remain limited. In this study, we explored the regulatory role of the Btla–Hvem axis in a ConA-induced hepatitis model in zebrafish. Results showed that Btla and Hvem were differentially expressed on intrahepatic Cd8+ T cells and hepatocytes. Knockdown of Btla or Hvem significantly promoted hepatic inflammation. Btla was highly expressed in Cd8+ T cells in healthy liver but was downregulated in inflamed liver, as evidenced by a disparate proportion of Cd8+Btla+ and Cd8+Btla– T cells in individuals without or with ConA stimulation. Cd8+Btla+ T cells showed minimal cytotoxicity to hepatocytes, whereas Cd8+Btla– T cells were strongly reactive. The depletion of Cd8+Btla– T cells reduced hepatitis, whereas their transfer enhanced hepatic inflammation. These observations indicate that Btla endowed Cd8+Btla+ T cells with self-tolerance, thereby preventing them from attacking hepatocytes. Btla downregulation deprived this tolerization. Mechanistically, Btla–Hvem interaction contributed to Cd8+Btla+ T cell tolerization, which was impaired by Hvem knockdown but rescued by soluble Hvem protein administration. Notably, Light was markedly upregulated on Cd8+Btla– T cells, accompanied by the transition of Cd8+Btla+Light– to Cd8+Btla–Light+ T cells during hepatitis, which could be modulated by Cd4+ T cells. Light blockade attenuated hepatitis, thereby suggesting the positive role of Light in hepatic inflammation. These findings provide insights into a previously unrecognized Btla–Hvem–Light regulatory network in hepatic homeostasis and inflammation, thus adding a new potential therapeutic intervention for hepatitis.
A Caspase-1 Biosensor to Monitor the Progression of Inflammation In Vivo
Authors: Talley Sarah , Kalinina Olga , Winek Michael , Paik Wonbeom , Cannon Abigail R. , Alonzo Francis , Choudhry Mashkoor A. , Knight Katherine L. , Campbell Edward M. 
Published: September 2019

Abstract
Inflammasomes are multiprotein complexes that coordinate cellular inflammatory responses and mediate host defense. Following recognition of pathogens and danger signals, inflammasomes assemble and recruit and activate caspase-1, the cysteine protease that cleaves numerous downstream targets, including pro–IL-1β and pro–IL-18 into their biologically active form. In this study, we sought to develop a biosensor that would allow us to monitor the initiation, progression, and resolution of inflammation in living animals. To this end, we inserted a known caspase-1 target sequence into a circularly permuted luciferase construct that becomes bioluminescent upon protease cleavage. This biosensor was activated in response to various inflammatory stimuli in human monocytic cell lines and murine bone marrow–derived macrophages. Next, we generated C57BL/6 transgenic mice constitutively expressing the caspase-1 biosensor. We were able to monitor the spatiotemporal dynamics of caspase-1 activation and onset of inflammation in individual animals in the context of a systemic bacterial infection, colitis, and acute graft-versus-host disease. These data established a model whereby the development and progression of inflammatory responses can be monitored in the context of these and other mouse models of disease.
Comments on “Review of the association between periodontitis and chronic obstructive pulmonary disease in smokers”
Authors: Pedron Irineu Gregnanin 
Published: September 2019

Comments on “Review of the association between periodontitis and chronic obstructive pulmonary disease in smokers” by Agathi Spiropoulou and colleagues, published in issue 1 of the 89th volume (2019) of the Monaldi Archives for Chest Disease.
Leadership Proficiency: Perspectives of Athletic Trainers New to Practice
Authors: Handlos Janelle L. , Ludwig Genevieve 
Published: September 2019

Context
A broad range of knowledge, skills, and abilities related to leadership has been suggested as essential for development during the athletic training education process. Though the importance of these characteristics has been established, researchers have not yet evaluated the self-perceived proficiency levels of new-to-practice athletic trainers (ATs).

Objective
To determine the level of self-perceived proficiency attained on key leadership competencies by new-to-practice ATs and to determine which factors relate to increased levels of self-perceived proficiency.

Design
Quantitative survey research.

Setting
Online questionnaire.

Patients or Other Participants
One hundred seventy-three ATs within their first 5 years of practice participated in the study.

Main Outcome Measure(s)
Participants completed a Web-based questionnaire developed by the researchers to determine the self-perceived level of proficiency attained by the new-to-practice AT on 5 key leadership competencies. One open-ended response item allowed participants to suggest educational experience changes that could lead to increased proficiency in the 5 key leadership competencies.

Results
Athletic trainers who completed their professional education at the master's level selected higher self-perceived proficiency levels for the competency knowledgeable than those who completed bachelor's degrees to complete their professional athletic training requirements. As years of practice increased, ATs perceived higher levels of proficiency in the competencies of knowledgeable, ethical practice, and credible. Level of self-perceived proficiency ratings for adaptable and resilient were significantly lower than those for other competencies, regardless of demographic variables.

Conclusions
Completion of professional education at the master's degree level resulted in increased self-perceived levels of knowledge in new-to-practice ATs. Self-perceived proficiency in the characteristic of adaptability and resilience lags behind other key competencies even as years of practice increase. Instructors could use pedagogical and curricular strategies from other health care professions to increase adaptability and resilience in athletic training students.