bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinicomycological Profile of Dermatophytosis in Tripura – An Institution Based Cross Sectional Study
Authors: Chakrabarti Syamal K. , Bhattacharjee Shibabrata , Goswami Bidhan , Sengupta Shauli , Bhattacharjee Bhaskar 
Published: October 2024

Abstract

Background:
In a small state like Tripura, a surge in prevalence of superficial dermatophytosis has been observed from April to September among the population of both tribal and non-tribal groups having different lifestyle, different food habit, and different socioeconomic status. Studies from different region reveal varying pattern of etiological distribution of the disease. But till date no research study has been initiated in Tripura on clinicomycological profile of dermatophytosis.

Objectives:
This study was undertaken with the objectives to estimate the proportion of different fungal species associated with dermatophytosis among the patients attending Dermatology Outpatient Department of a Tertiary care hospital of Tripura and also to determine possible association of different clinical parameters with fungal species if any.

Materials and Methods:
A total of three hundred and ninety-one (391) new cases of dermatophytosis attending Dermatology Outpatient Department of a Tertiary care teaching hospital of Tripura were included in this study from June, 2021 to May, 2022. All the specimens were assessed by direct microscopic examination and in vitro culture. Fungi were identified on the basis of their macroscopic and microscopic features with the help of lactophenol cotton blue staining and urease test.

Results:
There was a male preponderance among cases and maximum patients belonged to 21-40 years age group. Trichophyton schoenleinii was the most common fungal species (52.1%) grown in culture followed by Trichophyton rubrum (26.9%).

Conclusion:
In contrast to previous study results from different parts of India, Trichophyton schoenleinii was the most common isolated fungal species from this part of northeast India, and Tinea corporis (41.3%) was the most prominent clinical manifestation of dermatophytosis.
Hundred Most Cited Articles in Actinic Keratosis: A Bibliometric Analysis
Authors: Li Yizhi , Qi Zuoyao , Du Chichi , Jiang Guan 
Published: October 2024

Abstract
Many articles have been published on actinic keratosis. Bibliometric analysis helps identify the most influential studies in a particular field, Our article was to identify the 100 most frequently cited references on actinic keratosis through bibliometric analysis. As of March 1, 2020, actinic keratosis was searched in the Web of Science database and ranked in order of the total number of citations. The top 100 most cited articles in actinic keratosis were analysed. The top 100 most cited articles on actinic keratosis were published between 1982 and 2020. The largest number of articles were published in a single interval in 2001–2005. The average annual citations increased first and then decreased. The total citations were positively correlated with annual citations. The 100 articles were classified into different research focuses: pathogenesis (33%), treatment (24%), clinical features and diagnosis (15%), pathophysiology (8%), epidemiology (5%), associated diseases (2%) and others (13%). Among these 100 articles, 5 were clinical trials, 14 focused on the association between actinic keratosis and P53, and 9 reported the association between actinic keratosis and 5-aminolevulinic acid. The 100 articles were published in 38 journals by 87 different first corresponding authors from 15 different countries, mostly in the USA and Australia. Stockfleth, E from the University of Berlin published the most articles as the corresponding author. The top 100 cited references of actinic keratosis were identified and their bibliometric characteristics were analysed to lay a foundation for further research.
Neutrophil/Lymphocyte Ratio as a Biomarker of Response to H1-Antihistamine Therapy in Patients with Chronic Spontaneous Urticaria
Authors: Qiu Xiaonan , Ran Qiao , Pan Juanjuan , Tan Guozhen 
Published: October 2024

Abstract

Backgrounds:
A large proportion of patients with chronic spontaneous urticaria (CSU) are resistant to a standard dose of antihistamine. Acknowledged biomarkers for identifying these patients have not been determined. The neutrophil/lymphocyte ratio (NLR) has been considered as an important indicator of inflammation in chronic diseases.

Aims:
To explore whether NLR could serve as a biomarker for predicting the response to H1-antihistamine in patients with CSU.

Methods:
This hospital-based, retrospective study included 109 patients with CSU diagnosed from 2017 to 2020 in our clinic and divided them into two groups by their responses to the 2-week antihistamine therapy of standard-dose: 69 with H1-antihistamine-refractory and 40 with non-H1-antihistamine-refractory CSU. The laboratory test results were collected from the hospital information system and integrated with SPSS software.

Results:
Patients refractory to H1-antihistamine had significantly higher median NLR (P = 0.039), age (3 P = 0.021), complement C3 (P = 0.026), presence of elevated WBC (P = 0.026) and elevated monocytes (MONO) (P = 0.045) and significantly lower IgM (P = 0.022). The binary logistic regression model revealed that NLR was significantly associated with H1-antihistamine-refractory of CSU (odds ratio (OR) 1.717, 95% confidence interval (CI) 1.065–2.766, P = 0.026), which was consistent with that after adjusted for potential confounding factors including age, complement C3, presence of elevated WBC and MONO, and IgM (OR 1.681, 95% CI 1.019–2.773, P = 0.042).

Conclusion:
Our results showed a strong and significant association between higher NLR and H1-antihistamine resistance in CSU, suggesting that NLR may be a potential biomarker for predicting the response to H1-antihistamine therapy in patients with CSU.
Development and sensory evaluation of Moringa oleifera–enriched snack bar for micronutrients deficiency in adolescents
Authors: Sandhya Joseph Joy , Kanniammal Chinnathambi 
Published: October 2024

Background: This study aimed to assess the sensitivity, texture, and nutritional quality of Moringa-enriched wheat bars to improve the nutritional status of the adolescent population. Moringa, which has gained a nutraceutical perspective from various pieces of research, is being incorporated into food product development. Moringa leaves from the “miracle tree,” a habitat of origin from South Asia, are enriched with macro- and micronutrients that combat both malnutrition and hidden hunger (micronutrient deficiency). The phytochemical properties of Moringa leaves, such as their antidiabetic, anticancer, antiulcer, antimicrobial, and antioxidant properties, make them a superfood. Purpose: This study aimed to develop a snack bar incorporating Moringa flour that aligns with adolescents’ snacking preferences while also providing an adequate supply of iron. Materials and Methods: Moringa leaves were processed using the conventional method to obtain sieved, coarse Moringa leaf flour. Moringa oleifera snack bars were prepared at concentrations of 15% (M1), 10% (M2), and 5% (M3). The snack bar that shows high acceptability was subjected to nutritional evaluation to determine the specific iron content. Results: Organoleptic evaluation of M3, M2, and M1 by 24 semitrained personnel identified M3, at a 5% concentration, as the most acceptable. The nutritionally analyzed M3
M. oleifera snack bar contained protein (12.1 g), fiber (9.18 g), iron (10.1 g), magnesium (112 mg), calcium (345 mg), zinc (19.4 mg), and a good source of energy (447 kcal). Discussion:
Moringa, as a nutraceutical agent, in addition to its average dietary value utilized in nutritional snack bar development, aids in health promotion and disease prevention among adolescents with unhealthy food habits, such as consuming junk food. Conclusion: The M. oleifera snack bar supplies the recommended dietary allowance of micronutrients and macronutrients and contains antioxidants, such as flavonoids.
Development of ready-to-eat nutri bar from black soybean (Kala Bhatt) and millets: Exploring traditional foods of Uttarakhand
Authors: Gupta Divya , Harti Shivakumar Shankar 
Published: October 2024

BACKGROUND:
Malnutrition, particularly insufficient intake of certain micronutrients, limits a child’s ability to survive, grow, and develop. It increases the rate of morbidity and mortality among the most vulnerable populations, which significantly lowers their productivity as an adult. While adopting strategies to tackle malnutrition, regional diets must also be considered.

METHODS:
Based on the nutritive values, some staple ingredients from Uttarakhand, such as black soybean, finger millet, and foxtail millet, have been utilized to develop a ready-to-eat (RTE) packaged nutri-bar. A sensory characteristic evaluation of the product has been carried out. The product has been evaluated in the laboratory for its proximate composition, some minerals, presence of heavy metals, pesticide, and shelf-life.

RESULTS:
The proximate composition of RTE nutri-bar includes protein content 18.16%, carbohydrate content 54.82%, total fats 12.13%, moisture 12.21%, and an ash value of 2.68%. Dietary fiber content is found to be 8.09%, and the energy evaluated for a 100-g sample is 401.09 Kcal. Calcium is present in very good amounts, that is, 478.44 mg/100 g. The amount of pesticide residues and added anti-oxidants are found below the level of quantification.

CONCLUSION:
The use of traditional foods in local communities has declined, but it may be revived with an appropriate framework, policy, and information sharing in conjunction with contextual food-based treatments.
Awareness, perception, and practices of Ayurveda doctors toward FSSAI (Ayurveda Ahara) Regulations Act 2022: A cross-sectional survey
Authors: Kapoorchand Hemalatha 
Published: October 2024

BACKGROUND:
The Food Safety and Standards Authority of India (FSSAI; Ayurveda Ahara) Regulations Act 2022 was established by the FSSAI to regulate the safety, quality, and labeling of Ayurvedic food products. This Act is specifically designed to distinguish Ayurvedic food products from Ayurvedic medicines and proprietary drugs, ensuring that they meet strict standards of safety and authenticity. This study aims to assess the knowledge, attitudes, and practices of Ayurvedic doctors regarding the FSSAI (Ayurveda Ahara) Regulations Act 2022. It seeks to understand their level of awareness and implementation of these regulations in clinical practice and to identify areas for further education or training.

METHODS:
A cross-sectional online survey was conducted from April 4, 2024, to June 20, 2024, using Google Forms. The semi-structured questionnaire included 31 questions divided into four sections covering knowledge, attitudes, and practices toward the FSSAI Ayurveda Ahara regulations. The survey included 148 qualified Ayurvedic doctors from across India. Descriptive analysis of the data was performed, and the results were expressed as percentages.

RESULTS:
Out of 148 respondents, 85.1% were aware of the FSSAI Ayurveda Ahara regulations, but only 14.2% were thoroughly familiar with them. Most respondents had acquired knowledge through professional associations (83.7%) and medical journals (72.9%). While 81.8% of the doctors believed in the significant role of the regulations in public health, practical challenges such as the availability of compliant products and patient adherence were identified. Only 54.7% of doctors were likely to incorporate compliant Ayurvedic food products into their treatment recommendations.

CONCLUSION:
The study highlights the need for enhanced education and dissemination of detailed information about the FSSAI (Ayurveda Ahara) Regulations Act 2022. Despite positive attitudes toward the regulations, practical application is hindered by significant challenges. Addressing these gaps through targeted training programs, improved information dissemination, and supportive measures is essential for effective implementation.
A narrative review on the role of naturopathy in the management of diabetes mellitus
Authors: Mooventhan A. , Gowthami R. , Krishnamurthy Dhansri , Nivethitha L. 
Published: October 2024

Abstract:
Diabetes mellitus is a group of metabolic diseases characterized by chronic hyperglycemia resulting from defects in insulin secretion, insulin action, or both. Alternative therapies with antihyperglycemic effects are increasingly sought after by patients with diabetes. Some potential alternative treatments for diabetes include yoga and naturopathy, which encompass hydrotherapy, massage therapy, mud therapy, acupuncture, and more. While there are review articles on various alternative therapies for diabetes individually, no known reviews have reported the collective effect of naturopathy therapies, including acupuncture, on diabetes. This comprehensive review was conducted using PubMed/Medline and Google Scholar electronic databases, aiming to provide evidence-based effects of naturopathy therapies such as hydrotherapy, mud therapy, fasting therapy, diet therapy, massage therapy, magnetotherapy, acupuncture, and reflexology, commonly practiced in India, on the management of diabetes. The literature suggests that these treatment modalities significantly improve type 2 diabetes mellitus (T2DM). However, more studies are needed to understand the comprehensive effects of administering these treatments, either individually or in combination, in effectively treating T2DM.
A rare case of respiratory syncytial virus bronchiolitis with spontaneous bilateral pneumothorax in an infant
Authors: Mishra Reshmi , Rup Amit Ranjan , Jain Mukesh Kumar , Sahoo Bandya , Patnaik Sibabratta 
Published: October 2024

Abstract:
The most common self-limiting viral infection of the lower respiratory tract in the pediatric population is bronchiolitis, which most commonly affects infants. In most cases, respiratory syncytial virus (RSV) is the causative agent. In general, the recovery occurs within 5–7 days without any complications. Spontaneous pneumothorax is one of the rare and less-reported complications of bronchiolitis. We report a case of a male child aged 5 months with bilateral spontaneous pneumothorax (PNO) with subcutaneous emphysema following bronchiolitis. The nasopharyngeal swab was positive for RSV, and all other investigations ruled out any underlying illness causing spontaneous PNO. Although it is a rare complication of bronchiolitis, it may occur late during the disease course. Pediatricians must be aware of this life-threatening complication, which may develop during the disease course despite an early clinical improvement.
Teflon flu: Is it a rising concern of only developed country?
Authors: Pati Sanghamitra , Das Dasarathi , Sinha Abhinav , Mahapatra Pranab , Turuk Jyotirmayee 
Published: October 2024

Abstract:
Teflon flu also known as polymer fume fever is a temporary flu-like illness caused by inhaling fumes released when polytetrafluoroethylene (PTFE), the chemical used to make non-stick coatings like Teflon, is heated to very high temperatures. This condition typically occurs when non-stick cookware is overheated to above 500°F (260°C), releasing fumes that can cause symptoms in humans. Teflon flu is manifested with fever, chills, headache, body aches, cough, sore throat and shortness of breath which usually appear within a few hours of exposure and may last for a day or tw. Teflon flu is generally not considered dangerous for healthy individuals but repeated exposure could have more serious effects. Although in India cases are not widely reported as in countries like the U.S., India’s medical community, including the Indian Council of Medical Research has advised caution and advocated use of earthen pots for cooking. Here we discuss in detail the causes, and ways to prevent Teflon flu in Indian context.
Evaluation of Rajapravartani Vati and Saraswatarishta in dysmenorrhea: A study protocol for a single-arm, multicenter, and community-based study
Authors: Mata Sunita , Makhija Deepa , Manathottathil Aparna , Tripathi Arunabh , Rana Rakesh Kumar , Rana Kiran , Sharma Abha , Joshi Vandana , Chandrasekhara Rao Bhogavalli , Srikanth Narayanam , Acharya Rabinarayan 
Published: October 2024

Abstract

BACKGROUND:
Primary dysmenorrhea is one of the major public health concerns that affects about 50%–90% of women. Even though the condition is associated with psychosomatic symptoms, conventional management is mainly focused on reducing pain only. This study is designed to evaluate the potential of Ayurvedic management in dysmenorrhea, addressing both physical and psychosomatic aspects of the condition.

OBJECTIVE:
The study aims to assess the effectiveness and tolerability of Rajapravartani Vati and Saraswatarishta in dysmenorrhea.

MATERIALS AND METHODS:
This study is a prospective, single-arm, open-label, and multicenter clinical study involving 10 centers. According to pre-defined selection criteria, a total of 460 participants with primary dysmenorrhea in the age range of 14–25 years will be enrolled from the study sites. All participants will receive Rajapravartani Vati 500 mg twice daily orally starting from 7 days before the expected date of the menstrual cycle up to the third day of menstruation for three consecutive menstrual cycles. Saraswatarishta will be given, a 10 mL dose with 20 mL of lukewarm water at bedtime for 84 days. The participants will be followed for further 3 months to assess the sustained effect of the intervention. The change in pain, disease-specific symptoms, and psychosomatic status will be assessed for three consecutive cycles by using the Visual Analog Scale score, Working Ability, Location, Intensity, Days of pain, Dysmenorrhea score, and Moos Menstrual Distress Questionnaire, respectively. The tolerability of the drugs will be assessed through the occurrence of treatment-emergent adverse events during the study period, and compliance to study interventions.

DISCUSSION:
This study will help in providing evidence-based scientific data related to the clinical evaluation and tolerability of Rajapravartani Vati and Saraswatarishta in dysmenorrhea.

TRIAL REGISTRATION:
CTRI/2023/07/054617 dated July 3, 2023.
Management of varicose ulcer complicated with class II cellulitis through multimodal Ayurvedic interventions: A case report
Authors: Peethambaran Sinimol Thekkekkoottumughath , Sumedhan Varsha , Somaraj Lisha 
Published: October 2024

Abstract
This case report describes a 45-year-old female homemaker with a varicose ulcer complicated by class II cellulitis on her right lower limb. The ulcer, which appeared 26 days before presentation to OPD measured 7.5 cm × 3 cm × 0.2 cm and was located midway between the popliteal fossa and the ankle joint. It was associated with pain and serous discharge, and the surrounding skin exhibited erythema (redness), indicative of cellulitis. An emergency Doppler study of the venous system of the right lower limb was done, which ruled out deep venous thrombosis. As no relief was obtained from the external application of povidone-iodine ointment for about 2 weeks as suggested by conventional treatment, the patient came to the outpatient department of Regional Ayurveda Research Institute, Thiruvananthapuram, Kerala, India. A diagnosis of varicose ulcer complicated with class II cellulitis was established based on the clinical examination, relevant laboratory investigations, and detailed patient history. A comprehensive multimodal Ayurvedic treatment was administered, including internal medications like Panchanimbakwatha, Kaisoraguggulu, Triphalaguggulu, Punarnavadi Paneeya, and Madhusnuhi Rasayana for 20 days. Tablets Mahasudarshanam and AYUSH-64 were given for the first 2 weeks to manage cellulitis, which subsided during this period. The grading of venous insufficiency was C6 according to the “Clinical, Etiology, Anatomic, Pathophysiology classification” on day 1, improved to C1 by day 42 following treatment, indicating significant recovery. According to the “National Pressure Injury Advisory Panel Classification,” the ulcer was graded as Stage 3 on the day with significant improvement by day 42, where only mild discoloration of the overlying skin remained. The medications used for treatment had properties, such as Raktashodhaka (blood purifying), Krimighna (antimicrobial), Soolahara (anodyne), Vranashodhaka (wound-cleansing), Vranaropana (wound-healing), Sophahara (anti-inflammatory), and Pittahara (alleviate Pitta Dosha). In Ayurveda, venous ulcers can be considered as Siragranthijanyavran and cellulitis as Sirashotha. This case highlights the importance of timely intervention in the management of varicose ulcers complicated by cellulitis. The Ayurvedic therapeutic regimen demonstrated in this case offers an effective approach to managing complicated cellulitis in varicose ulcers, emphasizing the potential of Ayurveda in treating chronic conditions when addressed promptly.
In vitro Effect of Low-level Lasers on Proteomic Concentration in Human Blood Plasma Using 375 nm and 650 nm Lasers
Authors: Al-Kaabi Ahmed Abdulkareem , Al-Mosawi Mustafa , Al-Bayati Ali Abdullateef Abdulateef 
Published: October 2024

Abstract

Background:
As a continuation of earlier laboratory research and its findings, we are studying the effects of biostimulation and alteration on human blood plasma to improve blood circulation in blood vessels, treat some infections, and treat various diseases, including blood protein-related ones.

Methods:
Blood samples were collected through venipuncture into tubes containing, ethylenediaminetetraacidic as an anticoagulant from healthy adult donors, and plasma was separated from blood components. Blood plasma samples were irradiated for varying periods (5, 10, 15, and20) min. Before and after irradiation, total protein and albumin concentrations were calculated using 375 nm and 650 nm lasers. Using a spectrophotometer, the concentration of total protein and albumin was determined for each sample.

Results:
At the (375 and 650) nm laser wavelength and exposure durations of (5, 10, 15, and 20) min, it was observed that the total protein concentration had significant differences between pre- and postirradiation probate value (P = 0.05, P = 0.05, P = 0.05, and P = 0.05, respectively). It was observed that the total protein and albumin concentrations had significant differences between pre- and postirradiation. In addition, the results demonstrate that the concentration of total protein and albumin decreases more significantly at a laser wavelength of 650 nm compared to a laser wavelength of 375 nm at times of (5 and 10) min.

Conclusions:
Our results clearly indicate that low-level lasers with different wavelengths of ( 375 , 630) nm both affect the concentration of total protein and albumin in human blood plasma, which can contribute to the treatment of many pathological conditions in the future.