bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hubungan Nilai PH Cairan Pleura dengan Hasil Pleurodesis pada Penderita Efusi Pleura karena Keganasan
Authors: Marhana Isnin Anang , Handoko Asep Tri 
Published: June 2019

Background: Pleural effusion is a frequent complication of advanced stage are obtained in patients with malignancy. Shortness of breath at rest and decreased exercise tolerance are major functional limitations for patients with cancer who develop extensive pleural effusion. Pleural fluid drainage followed by a pleurodesis can reduce the symptoms of shortness of breath and prevent pleural fluid reaccumulation. Unfortunately, pleurodesis attempts fail in 10 to 40% of patients with recurrent pleural fluid and shortness of breath. Low pleural fluid pH can be used as a marker for increased metabolic activity of tumors in intrapleura, and is associated with increasing tumor, and can predict the failure of pleurodesis. The purpose of this study was to prove association between low pleural fluid pH value with failure pleurodesis in patients pleural effusion malignancy. Method: This is an observational study with cross sectional design that is the analysis conducted at Hospital Dr Soetomo in patients pleural effusion malignancy were subjected to pleurodesis for 6 months. Total 11 patients who meet the inclusion and exclusion criteria. Result: The mean value obtained pleural fluid pH 7,3±0,2, based on logistic regression analysis obtained low pleural fluid pH is not significant association with failure of pleurodesis, as shown from the significant value generated wald test is 0,116 where the value is above 0,05. Conclusion: Low pleural fluid pH is not significant association with failure of pleurodesis.
NEEDS ANALYSIS OF MODULE TEACHING MATERIALS OF GORONTALO MUHAMMADIYAH ORGANIZATION IN LEARNING HISTORY AT SMAN 1 GORONTALO
Authors: Malae Andris K , Warto Warto , Djono Djono 
Published: June 2019

<p>This paper aims to analyze the needs of teaching materials module history of movement organization Muhammadiyah Gorontalo at SMAN 1 Gorontalo.This is done because, in the learning in the school has not used the module as a companion of textbooks. The research method used is descriptive-qualitative, that is by doing observation, interview and document study. The results showed that during the learning process of history at SMAN 1 Gorontalo, less exploration of local history studies, especially related to the movement of the Muhammadiyah organization. On the one hand, students need a new understanding of the local history of Gorontalo. Thus, the use of a module containing the historical material of Muhammadiyah organization movement in Gorontalo becomes important to be compiled, then taught to students. The goal is that students can know that the Gorontalo region also has a variety of history that is not less interesting when compared with other areas in Indonesia. The implications of this study can be used as a guide to the teacher in analyzing the various learning needs required by students during the learning process at school.For students, with the teaching material of this module, more exploring willingness learn according to requirement given by teacher.</p><p> </p><center><a href="http://creativecommons.org/licenses/by-sa/4.0/" rel="license"><img src="https://i.creativecommons.org/l/by-sa/4.0/88x31.png" alt="Creative Commons License" /></a><br />This work is licensed under a <a href="http://creativecommons.org/licenses/by-sa/4.0/" rel="license">Creative Commons Attribution-ShareAlike 4.0 International License</a></center><p> </p>
IMPROVEMENT EARLY COUNTING ABILITY WITH FUN COOKING ACTIVITIES
Authors: Risina Duana Fera 
Published: June 2019

<p>The objectives of the study is to know the process of fun cooking activities and increase early counting in children with learning math fun cooking activities. Fun cooking is a process of making food and drink until finally produce a product that can be eaten and done with fun. Through cooking the child will learn about language skills, mathematical concepts, skills in the process of science, experimental skills, coordination of physical skills, social skills, food and nutritional concepts. Observations made in five Kindergarten Group B in Kecamatan Selo, Boyolali found that teachers teach counting children still the old way, teachers use activity sheets in learning to count and do not use instructional media. Fun cooking activities using action research design (action research) model of Kemmis and Taggart, covering the planning, action, observation and reflection. Data analysis using quantitative and qualitative analysis (mixed methods). Quantitative data were analyzed using descriptive analysis (frequency tables, mean, percentage, standard deviation) while the qualitative data were analyzed by step 1) data reduction, (2) data display, and (3) verification of data.</p><p> </p><p> </p><center><a href="http://creativecommons.org/licenses/by-sa/4.0/" rel="license"><img src="https://i.creativecommons.org/l/by-sa/4.0/88x31.png" alt="Creative Commons License" /></a><br />This work is licensed under a <a href="http://creativecommons.org/licenses/by-sa/4.0/" rel="license">Creative Commons Attribution-ShareAlike 4.0 International License</a></center><p> </p>
PROJECT – BASED LEARNING (PJBL) TO IMPROVE STUDENTS’ WRITING CAPABILITY
Authors: Sholihah Umi 
Published: June 2019

<p>Writing is considered as a difficult skill in learning English. That’s way the teacher should creative and innovative in teaching writing. One of methods that can be used in teaching writing is PjBL (Project Based Learning). The purpose of this article is to examine the uses of PjBL can improve students’ writing capability. It is based on the classroom action research with the subject is the students of fourth semester of English department of Widya Dharma University. The findings of the research imply that PjBL is very effective. The implementation of PjBL improved the students’ writing capability. PjBL enables the students to be more active to explore their ideas. By doing the project, the students can work together and share their ideas and knowledge with others. It makes the learning activity is not teacher centered but student centered, because most of the activity is done by the students. It can also improve writing class in a better situation in the way that the classroom situation becomes more alive with various interesting activities, and there is a rising of students’ participation.</p><p> </p><p> </p><center><a href="http://creativecommons.org/licenses/by-sa/4.0/" rel="license"><img src="https://i.creativecommons.org/l/by-sa/4.0/88x31.png" alt="Creative Commons License" /></a><br />This work is licensed under a <a href="http://creativecommons.org/licenses/by-sa/4.0/" rel="license">Creative Commons Attribution-ShareAlike 4.0 International License</a></center><p> </p>
TEACHER RECRUITMENT IN PUBLIC ELEMENTARY SCHOOLS
Authors: Paramita Petra Patria D 
Published: June 2019

<p>In order to get qualified teachers and meet the needs of teachers in schools, it is necessary to establish a teacher recruitment system. Teacher recruitment is an important step in teacher management because from this process teachers will be screened and then later placed in school. Qualified teachers from this process will ensure the quality of education in the school. There are two paths of recruitment for public school teachers: through government test (CPNS) and schools internal recruitment. The purpose of this research is to examine whether these two processes produce different teacher qualities and be able to get teacher who can comply with the requirement specified by the law.</p><p> </p><p> </p><center><a href="http://creativecommons.org/licenses/by-sa/4.0/" rel="license"><img src="https://i.creativecommons.org/l/by-sa/4.0/88x31.png" alt="Creative Commons License" /></a><br />This work is licensed under a <a href="http://creativecommons.org/licenses/by-sa/4.0/" rel="license">Creative Commons Attribution-ShareAlike 4.0 International License</a></center><p> </p>
Designing Digital Teaching Media for Millennial Teachers: Trends and Sense
Authors: HARYATI SRI 
Published: June 2019

<p align="justify">Digital-based teaching media possess very high production quality capable of showcasing complex ideas in a short period of time. Later, the digital-based teaching media is well developed in millennial era indicating by the productivity escalation of it. This study aim at investigating (1) the trending application resorted by the teaching media designers to create the digital-based teaching media; (2) the problems faced by millennial teachers in creating the digital-based teaching media; (3) the underlying factors of the problems; (4) the efforts of digital teaching media designers to overcome the problems. Using descriptive qualitative, the 129 digital teaching media designers (millennial teachers) within 22-37 years old were investigated about the process and the product of digital-based teaching media. Questionnaire, interview, and document analysis used to assemble the data. The data were analyzed using the Interactive Model of data analysis. Triangulation technique facilitated the data validation and verification later. The result of the research shows that (1) the there are trending applications resorted by designer to create the digital teaching media such as prezi, movie maker and kine toon; (2) Less creativity and understanding towards technology become the major problems; (3) The lack of knowledge in technology and the dependency to make use the ready-made digital teaching media be the prominent factors causing the problem in designing digital teaching media; (4) Enhancing the creativity, innovation and technology sensitivity is the top solution proposed by teachers. The research implies that being the digital teaching media developers need extra efforts. Moreover, improving the technology sensitivity towards the current technology for teaching assists the designer better.</p>
Words Problem Based Creation for Thematic Mathematical Stories: A Collaborative Action Research
Authors: Sumarwati Sumarwati , Budiyono Budiyono , Anindyarini Atikah 
Published: June 2019

This research aims to improve the classroom practices of rural primary teachers in developing mathematics word problem through collaborative action research. The cooperation between fourth grade teachers and researchers from university focused on examining the results of the implementation of the two activities within the action plans, ‘Creating word problems communicatively based by teachers’ and ‘Solving word problems easily by students’. From the analysis of qualitative data (interviews with students, observation and journal entries) and quantitative (tests and questionnaires) seen a significant improvement of the results of teacher in word problem creating and students in word problem solving. Developing word problem based on thematic mathematical stories enabled students to guide in using storytelling as a tool for understanding word problems
RNA-Seq reveals differential expression profile and functional annotation of genes involved in retinal degeneration in Pde6c mutant Danio rerio
Authors: Saddala Madhu Sudhana , Lennikov Anton , Huang Hu 
Published: June 2019

Abstract
Retinal degenerative diseases affect millions of people and are the leading cause of vision loss. Retinal degeneration has been attributed to a wide variety of causes, such as disruption of genes that are involved in phototransduction, biosynthesis, folding of the rhodopsin molecule and the structural support of the retina. The molecular pathogenesis of the biological events in retinal degeneration is unclear. The molecular basis of the retinal pathologies defect can be potentially determined by gene-expression profiling of the whole retina. In the present study, we have analyzed the differential gene expression profile of retina from a wild-type zebrafish and pde6c mutant. The datasets were downloaded from the Sequence Read Archive (SRA), removed adaptors and unbiased bases and checked to ensure the quality. The reads were further aligned to the reference genome of zebrafish and calculated gene expression. The differentially expressed genes (DEGs) were filtered based on the FDR (±4) and p-values (p<0.001). We performed gene annotation (Molecular function, biological process, cellular component), and functional pathways (KEGG pathway) for the DEGs. Our result showed that 216 up-regulated and 3527 down-regulated between normal and pde6c mutant zebrafish. These DEGs are involved in various KEGG pathways like Phototransduction (12 genes), mRNA surveillance pathway (17 genes), Phagosome (25 genes), Glycolysis / Gluconeogenesis (15 genes), Adrenergic signalling in cardiomyocytes (29 genes), Ribosome (20 genes), Citrate cycle (TCA cycle) (8 genes), Insulin signalling pathway (24 genes), Oxidative phosphorylation (20 genes) and RNA transport (22 genes) pathways respectively. Much more of all the pathways genes were down-regulated, but fewer genes were up-regulated in retina mutant of zebrafish. Our data strongly indicate that the among these genes, above mentioned pathways genes as well as calcium-binding proteins, neural damage proteins, peptidase proteins, immunological proteins, and apoptosis proteins are mostly involved in retinal and neural degeneration that cause abnormalities in photoreceptors or RPE cells.
The Comparison between Sepsis 1.0 and Sepsis 3.0 in Database of Severe Infection in Critical Illness: A Retrospective Study
Authors: Zhang Wei , Zheng Yan , Gu Juan , Kang Yan 
Published: June 2019

Abstract
Objective To compared the Sepsis 1.0 criterial with the Sepsis 3.0 criteria predict the efficacy of all-caused mortality of in-hospital in critically ill patients with severe infection. Design This is a retrospective and cohort study based on the database of severe infection. Setting A 48-bed general intensive care unit in affiliated hospital of University. Patients Critically ill patients with suspected infection based on the electronic health records from 1 January to 31 December, 2015. Interventions None. Measurements The variables of exposures included: quick sequential organ failure assessment (qSOFA), systemic inflammatory response syndrome (SIRS) score and sequential organ failure assessment (SOFA). Main outcomes and measures: for predictive validity, we found that the discrimination for hospital mortality was more common with sepsis than with uncomplicated infections. Results are reported as the area under the receiver operating characteristic curve (AUROC).Main Results In the primary cohort, 873 patients had suspected infection cohort (n=634), of whom 188 (29.7%) died; and with the non-infection cohort (n=239), 26 patients died (10.9%). Among intensive care unit (ICU) cases in the infection cohort, the predictive validity for hospital mortality was higher for Sepsis 3.0 (SOFA) criteria (AUROC=0.702; 95%CI, 0.665 −0.737; p≤0.01 for both) than for Sepsis 1.0 (SIRS) criteria (AUROC=0.533; 95% confidence interval [95%CI], 0.493−0.572). Conclusions In our study, we found the Sepsis 3.0 criteria is able to accurately predict the prognosis in critically ill patients with severe infection, and its predictive efficacy is superior to Sepsis 1.0 criteria.
Genomic regions related to white/black tail feather color in Dwarf chickens detected using a genome-wide association study
Authors: Nie Changsheng , Qu Liang , Jiang Zhihua , Wang Kehua , Qu Lujiang , Ning Zhonghua 
Published: June 2019

Abstract
Background: The genetic foundation of chicken tail feather color is not very well studied to date, though that of body feather color is extensively explored. In the present study, we used a synthetic chicken dwarf line (DW), which was originated from the hybrids between a black tail chicken breed, Rhode Island Red (RIR) and a white tail breed, Dwarf Layer (DL), to understand the genetic rules of the white/black tail color. The DW line still contain the individuals with black or white tails, even if the body feather are predominantly red, after more than ten generation of self-crossing and being selected for the body feather color. We firstly performed four crosses using the DW line chickens including black tail male to female, reciprocal crosses between the black and white, and white male to female to elucidate the inheritance pattern of the white/black tail. Furtherly, we performed a genome-wide association (GWA) analysis to determine the candidate genomic regions underlying the tail feather color by using black tail chickens from the RIR and DW chickens and white individuals from DW lines. Results: In the cross experiment, we found that (i) the white/black tail feather colors are independent of body feather color and (ii) the phenotype are autosomal simple trait and (iii) the white are dominant to the black in the DW lines. The GWA results showed that seven Single-nucleotide polymorphism (SNP) on chromosome 24 were significantly correlated with tail feather color. The significant region (3.97-4.26 Mb) perches nine known genes and five anonymous genes. The nine genes were: NECTIN1, THY1, gga-mir-1466, USP2, C1QTNF5, RNF26, MCAM, CBL and CCDC153. Conclusions: The study has revealed the white/black tail feather trait is autosome-linked in Dwarf chickens. In the genome significant ~0.29 Mb region, fourteen genes were found and some of them could play critical roles in the formation of white/black tail feather color, especially gene MCAM. Taken together, our research is the first study on genetics of tail feather color and could help the more understanding of feather pigmentation in chicken.
Integrated analysis of the physiology, RNA, and microRNA involved in black locust (Robinia pseudoacacia) rejuvenation
Authors: Zhang Zijie , Sun Yuhan , Han Chao , Dong Li , Guo Qi , Li Xiuyu , Cao Sen , Din Saleem Ud , Munir Zeeshan , Pérez-Pérez José Manuel , Li Yun 
Published: June 2019

Abstract
Background

Rejuvenation is a key process that enables perennial woody plants to regain growth potential. In Robinia pseudoacacia plantations, natural root sprouting individuals provide good material for studying the rejuvenation of woody plants. However, the physiological differences and molecular mechanisms underlying black locust rejuvenation remain unclear. In this study, we compared the physiological conditions and molecular responses of rejuvenated individuals and mother trees.

Results

Our analysis of leaf structures and physiological indices showed that the epidermis thickness, leaf thickness and leaf-tissue tightness of rejuvenated individuals were less than those of mother trees. The soluble-sugar content and total SOD activity of rejuvenated individuals were also lower than those of mother trees. The younger the rejuvenated individuals were, the lower the ABA content, ABA/ZT and GA3/ZT in the leaves. The ZT content increased with decreasing age of rejuvenated individuals. Using high-throughput sequencing strategies, the mRNA and miRNA involved in the rejuvenation of black locust were identified. RNA-seq identified 175,862 unigenes by de novo transcript assembly. Of those, 4,727 differentially expressed genes were identified based on clean reads mapped to the assembled transcriptome for gene expression analysis(fold change≥2 or ≤0.5 and q-value≤0.05). These genes were enriched to 53 gene ontology(GO) terms and 20 KEGG pathways (FDR≤0.01). Among these were a major pathway related to flavone and flavonol biosynthesis. High-throughput miRNA sequencing identified a total of 991 miRNAs, including 671 novel miRNAs. Furthermore, 262 known and 625 novel differentially expressed miRNAs were identified(fold change≥1.5 or ≤0.67 and p≤0.05). The main functions identified in the GO analysis of the target predictions overlapped with differentially expressed genes derived from RNA-seq. KEGG pathway enrichment showed that circadian rhythm-fly and signaling pathways regulating pluripotency of stem cells attracted considerable attention during rejuvenation.

Conclusion

Our study revealed physiological differences between rejuvenated individuals and mother trees of R. pseudoacacia. Differential genes between mother trees and rejuvenated individuals may vary according to the tree ages, but miRNAs may play a key regulatory role in rejuvenation. The same genotype system composed of root germinating individuals and mother-tree individuals provides a solid starting point for further elucidation of the rejuvenation of woody plants.
Elderly Females Fall More From Heights but Males Survive Less: Insights from an American Level 1 Trauma Center
Authors: El-Menyar Ayman , Tilley Elizabeth , Al-Thani Hassan , Latifi Rifat 
Published: June 2019

Abstract
Background

Approximately one third of subjects ≥65 year old and half of subjects ≥80 years old sustain a fall injury each year. We aimed to study the outcomes of fall from a height (FFH) among elderly. We hypothesized that in an elderly population, fall-related injury and mortality are the same in both genders.

Methods

A retrospective analysis was conducted between January 2012 and December 2016 in patients who sustained fall injury at age of at least 60 years and were admitted into a Level 1 Trauma center. Patients were divided into 3 groups: Gp-I: 60-69, Gp-II: 70-79 and Gp-III: ≥80 years old. Data were analyzed and compared using Chi-square, one-way analysis of variance (ANOVA) and logistic regression analysis tests.

Results

Forty-three percent (3665/8528) of adult trauma patients had FFH and 2181 (59.5%) were ≥ 60 years old and 52% were women. The risk of fall increased with age with an Odd ratio (OR) 1.52 for age 70-79 and an OR 3.40 for ≥80.

Females fell 1.2 times more (age-adjusted OR 1.24; 95% CI 1.05-1.45) and 47% of ≥80 years old suffered FFH. Two-thirds of FFH occurred at a height ≤1 meter. Injury severity (ISS, NISS and GCS) were worse in Gp-II, lower extremities max Abbreviated Injury score (max AIS) was higher in Gp-III. Overall mortality was 8.7% (Gp-I 3.6% vs. 11.3% in Gp-II and 14% in Gp- III). Males showed higher mortality than females in the entire age groups (Gp-I: 4.6% vs 1%, Gp-II: 12.9% vs 4.2% and Gp-III: 17.3% vs 6.9% respectively). On multivariate analysis, shock index (OR 3.80; 95% CI 1.27-11.33) and male gender (OR 2.70; 95% CI 1.69-4.16) were independent predictors of mortality.

Conclusions

Fall from a height is more common in elderly female patients, but male patients have worse outcomes. Preventive measures for falls at home still are needed for the elderly of both genders.