bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prognostic value of soluble angiotensin II receptor 1 and soluble angiotensin converting enzyme (CD 143) in patients with acute leukemia
Authors: Ebied Samia Abd El-Moneim , Sadek Nadia Aly , Zaki Nadia El-Sayed , Kaream Samir Ali Abd El- , Kashif Heba Khafagui Ahmed El 
Published: April 2019

AbstractBackgroundThe renin-angiotensin system (RAS) is a bioenzymic cascade that plays an integral role in cardiovascular homoeostasis by influencing vascular tone, fluid and electrolyte balance and the sympathetic nervous system. RAS was viewed as a circulating endocrine system, whereby renin released from the juxtaglomerular cells of the kidney cleaves the liver-derived macroglobulin precursor angio-tensinogen, to produce the inactive decapeptide angiotensin I, which is then converted to the active octapeptide Ang II by angiotensin converting enzyme (ACE) within the pulmonary. There is increasing evidence that Ang II, a major regulator of blood pressure and cardiovascular homeostasis, is involved in the regulation of cell proliferation, angiogenesis, inflammation and tissue remodeling, which suggests that this peptide might also play a role in cancer. Ang II is the main effector of the RAS and it alternatively binds to either Ang II T1R or Ang II T2R. The Ang II T1R and Ang II T2R can act as antagonists, and mediate effects on cell migration and proliferation of metastatic cancer cells and hemopoietic stem-progenitor cells. Components of the RAS are frequently differentially expressed in various cancers in comparison with their corresponding non- malignant tissue. Yet, the RAS has not been fully elucidated in patients with acute leukemia. Objective: The aim of the present work was to study serum level of Angiotensin II receptor type 1 and the soluble angiotensin converting enzyme (CD143) in patients with acute leukemia in order to extrapolate their possible prognostic value.Subjects and MethodsThe present study included 20 healthy volunteers clinically free from hypertension or sarcoidosis, 20 patients of newly diagnosed AML and 20 patients of newly diagnosed ALL. Blood samples were collected from all subjects and the level of serum ACE and serum Ang IIT1R were measured by enzyme linked immunossorbent assay.ResultsThe activity of ACE (U/L) and the concentration of Ang IIT1R (U/L) in patients groups with either AML or ALL before therapy were significantly higher than in control group. After therapy, the activity of the enzyme and its receptor concentration in both groups of patients were significantly decreased but still significantly higher than in normal control subjects.ConclusionsEstimating the serum level of ACE and soluble Ang IIT1R is of informative diagnostic and prognostic value. Estimation serum level of ACE and Ang IIT1R levels in patients with either AML or ALL is of value in deciding the treatment protocol.
The effects of amiodarone prophylaxis on cardiac dysrhythmia in acute aluminium phosphide poisoning
Authors: Beyranvand Mohammad-Reza , Farrokhi Soleyman , Peyvandi Hassan , Soltaninejad Kambiz , Shadnia Shahin 
Published: April 2019

Abstract
Cardiovascular toxicity is the most common cause of fatality in the first 24 hours of poisoning with aluminium phosphide (AlP). Most often manifesting itself in cardiac dysrhythmias. The aim of this study was to evaluate the benefits of amiodarone prophylaxis against cardiac dysrhythmia in 46 patients with acute AlP poisoning. They were divided in two groups of 23: one receiving amiodarone and the other not (control). The treatment group received amiodarone prophylaxis in the initial intravenous bolus dose of 150 mg, followed by a drip of 1 mg/min for six hours and then of 0.5 mg/min for eighteen hours. Both groups were Holter-monitored for 24 hours since admission. Save for amiodarone, both groups received the same standard treatment. Amiodarone had a significant beneficial effect in reducing the frequency of ST-segment elevation and ventricular fibrillation plus atrial fibrillation (P=0.02 and P=0.01, respectively), but the groups did not differ significantly in mortality (9 vs 11 patients, respectively). The mean time between ICU admission and death (survival time) was significantly longer in the treatment group (22 vs 10 h, respectively; P=0.03). Regardless its obvious limitations, our study suggests that even though amiodarone alone did not reduce mortality, it may provide enough time for antioxidant therapy to tip the balance in favour of survival and we therefore advocate its prophylactic use within the first 24 h of AlP poisoning.
Effects of simvastatin and fenofibrate on butyrylcholinesterase activity in the brain, plasma, and liver of normolipidemic and hyperlipidemic rats
Authors: Vukšić Antonija , Lovrić Jasna , Konjevoda Paško , Blažević Nina , Bilušić Marinko , Bradamante Vlasta 
Published: April 2019

Abstract
The study objective was to test the hypothesis that simvastatin and fenofibrate should cause an increase in butyrylcholinesterase (BuChE) activity not only in the plasma and liver but also in the brain of normolipidemic and hyperlipidemic rats. Catalytic enzyme activity was measured using acetylthiocholine (ATCh) and butyrylthiocholine (BTCh) as substrates. Normolipidemic and hyperlipidemic rats were divided in four groups receiving 50 mg/kg of simvastatin a day or 30 mg/kg of fenofibrate a day for three weeks and three control groups receiving saline. Simvastatin and fenofibrate caused an increase in brain BuChE activity in both normo- and hyperlipidemic rats regardless of the substrate. The increase with BTCh as substrate was significant and practically the same in normolipidemic and hyperlipidemic rats after simvastatin treatment (14–17% vs controls). Simvastatin and fenofibrate also increased liver and plasma BuChE activity in both normolipidemic and hyperlipidemic rats regardless of the substrate. In most cases the increase was significant. Considering the important role of BuChE in cholinergic transmission as well as its pharmacological function, it is necessary to continue investigations of the effects of lipid-lowering drugs on BuChE activity.
Happy 70, Archives! – our mission and vision for the years to come
Authors: Čakalo Dado , Kopjar Nevenka 
Published: April 2019

Abstract
This year we turn 70! Lucky for journals, they don’t get old with volumes. In our case, quite the opposite. The idea of this editorial, however, is not to look so far back but to share with you – our readers and authors – where we see Archives in the years to come.
Heat Treatment Effect on Lath Martensite
Authors: Fábián Enikő Réka , Kótai Áron 
Published: April 2019

Abstract
During our investigation lath martensite was produced in low carbon steels by austenitization at 1200 °C/20 min, and the cooling of samples in ice water. The samples were tempered at a range of temperatures. The tempering effects on microstructure and on mechanical proprieties were investigated. Some samples with lath martensite microstructure were cold rolled and heat treated at different temperatures. Recrystallization was observed after heat treatment at 600-700 °C.
Method for Emissivity Estimation of Metals
Authors: Filep Emőd , Kutasi Dénes Nimród , Kenéz Lajos 
Published: April 2019

Abstract
Knowledge of the surface emissivity of metals is becoming more and more important both from the material science, process modelling and control point of view. Previous research results have shown that the emissivity of most metals depends on the temperature of the surface. It has also been reported that the most important temperature region is between 300 – 1000 K degrees, where the change of the emissivity is the most intense, which is also the most significant from a process control point of view [1]. We also report temperature dependent emissivity observed during plasma nitriding of low alloy steels [2]. Related to one of our present research topics the study of the low alloy aluminum (AlMg1, AlMg3) emissivity has prooven relevant. In this article the developed emissivity estimation model is presented. In the first part a literature overview and the theoretical approach of the new method is discussed, followed by the experimental results for low alloy aluminium emissivity determination and a comparison with the results available in the literature.
Effect of Expansion Pressure on the Drug Eluting Coating and the Corrosion Characteristics of Coronary Stents
Authors: Horicsányi Krisztina , Asztalos Lilla , Károly Dóra , Fazakas Éva 
Published: April 2019

Abstract
During implantation, stents are delivered in crimped state to the narrowed lesion, where they are expanded to the desired size by the balloon. Due to insufficient size selection or high resistance to plaque, the stent is often widened by the expansion pressure to a level greater than the nominal pressure specified by the manufacturer. Depending on the degree of overpressure, the nominal diameter of the stent may change by several tenths of a millimetre. Numerous studies have dealt with the physiological effects of overexposure and stenogenic stress, but so far no studies have been carried out to investigate the stent coating and corrosion properties of the stent. In our research a widely used drug-eluting, platinum-chromium alloyed steel stent was observed with an inflation pressure of 12 and 18 bar. Scanning electron microscopy revealed lesions of the coating and potentiodynamic tests were performed to determine the corrosion rate.
Corrosion Testing of Additively Manufactured Metals and Biomedical Devices
Authors: Kemény Dávid Miklós , Károly Dóra 
Published: April 2019

Abstract
Additive manufacturing (AM) is becoming increasingly important, making it possible to produce a product in a short time, to specific individual requirements, and even in the presence of the customer. This research is related to direct metal laser sintering of additive manufacturing. This new technology is increasingly being used in more sectors, for example in biomedical industry, where a damaged product can potentially endanger human life. Corrosion tests were carried out during our research. Cyclic voltammetry curves and corrosion rates were determined with a potentiostat. Two typical biocompatible implant materials were compared, a cobalt chromium alloy (powder metallurgy) and a titanium alloy (3D printed). The results will help in specifying the corrosion properties of additively manufactured materials.
Investigation of Laser Welding Technology of Diamond Drilling Segments
Authors: Kenéz Attila Zsolt , Bagyinszki Gyula 
Published: April 2019

Abstract
Segments containing diamond particles are fixed to replaceable inserts or to steel tool bodies for cost-effectiveness. The joining technology used should meet both environmental and technical requirements. The joining zone is subjected to high mechanical and significant thermal loads during use. In the event of an improper joint, the segments may detach from the base and fly away causing injury. Nowadays, many methods of welding or brazing are used to fix diamond segments. Among the possible segment fixing technologies, laser beam welding has been investigated. The microstructure of the joints has been examined by optical and scanning electron microscopy and chemical element maps have been recorded. Joints have been subjected to fracture and hardness testing. The mechanical properties and composition changes of the joints with different joining technologies have been evaluated and compared.
Addictive and Substractive Combined Production of Cobalt-Crome-Based Frames in Dentistry
Authors: János Kónya , Klaudia Kulcsár 
Published: April 2019

Abstract
The following study analyses the use of modern 3D printing technology in dentistry with its necessary manufacturing and machining processes. Fitting of the manufactured metal structures is examined depending on their use, in terms of conventional adhesion-based denture designs and screw-fixed dentures on implants. Influencing factors and effects of the required post-processing steps are examined. Aspects such as sand-blasting, heat treatment, equipment and tools required for cutting are analyzed. The aim of this study is to create a manufacturing process that enables the required precision fitting of the created frame structure types.
Application of High Energy Absorbing Materials for Blast Protection
Authors: Kovács Tünde , Nyikes Zoltán , Figuli Lucia 
Published: April 2019

Abstract
In the current century, building protection is very important in the face of terrorist attacks. The old buildings in Europe are not sufficiently resilient to the loads produced by blasts. We still do not fully understand the effects of different explosives on buildings and human bodies. [1–3] Computing blast loads are different from that of traditional loads and the material selection rules for this type of impact load are diverse. Historical and old buildings cannot be protected simply by new walls and fences. New ways need to be found to improve a building’s resistance to the effects of a blast. It requires sufficiently thin yet strong retrofitted materials in order to reinforce a building’s walls [4–6].
Mechanical Studies of Injection Molded Composites with Polypropilene Matrix
Authors: Istvánné Ráthy , Péter Pinke , Csenge Huszák 
Published: April 2019

Abstract
The wide use of composite materials is mainly due to their excellent strength / mass ratio, corrosion resistance and relatively low price. Approximately 35-40% of the fibre-reinforced composites are made of thermoplastic polymers in which fibreglass, carbon or natural fibres are most often used as reinforcement, while the remaining 60 – 65% is made up of high-tech carbon or glass fibre-reinforced thermosetting composites. Most of them are used in the transport and electronics industries. New processing technologies not only improve the properties of the products but also contribute to reducing costs.
In this paper, we compare the results of mechanical tests with molded standard specimens with polypropylene matrix and test results from cut-outs from injection molded products.
The Effect of Administration of Copper Nanoparticles in Drinking Water on Redox Reactions in the Liver and Breast Muscle of Broiler Chickens
Authors: Ognik Katarzyna , Cholewińska Ewelina , Stępniowska Anna , Drażbo Aleksandra , Kozłowski Krzysztof , Jankowski Jan 
Published: April 2019

Abstract
The aim of the study was to determine what dosage of copper nanoparticles added in the form of a hydrocolloid to standard dietary supplementation with copper sulphate will increase the antioxidant potential in the liver and breast muscle of chickens. In total, 126 one-day-old Ross 308 chickens were assigned to 7 experimental groups of 18 birds each (3 replications of 6 individuals each). The basal-diet treatment did not receive nano-Cu. Experimental groups received nano-Cu (0.5, 1.0 or 1.5 mg/kg body weight per day) via a tube into the crop over three 3-day periods (days 8–10, 22–24 and 36–38) or three 7-day periods (days 8–14, 22–28 and 36–42). Dietary supplementation of chickens with nano-Cu to exceed the Cu level recommended by the NRC increased the content of Cu (P=0.042) while reducing that of Zn in the liver (P=0.031) and breast muscle (P=0.036). Supplementing the diet of chickens with nano-Cu to a level exceeding the level of copper recommended by the NRC by 7% to 25% increased the antioxidant potential of the liver and the breast meat. The study has shown that the antioxidant status of the liver and breast meat of chickens can be improved by supplementing the standard dietary copper sulphate supplement with the addition of nano-Cu, but to a level not exceeding 25% of the copper content recommended by NRC (1994) for broiler chickens, but the most safe is the nano-Cu level not exceeding 7% of the copper content recommended by NRC (1994).
The Physiological and Productivity Effects of Heat Stress in Cattle – A Review
Authors: Herbut Piotr , Angrecka Sabina , Godyń Dorota , Hoffmann Gundula 
Published: April 2019

Abstract
A trend of global warming has been observed over the last few years and it has often been discussed whether there is an effect on livestock. Numerous studies have been published about heat stress in cattle and its influence on the physiology and productivity of animals. Preventing the negative effects of heat stress on cattle is essential to ensure animal welfare, health and productivity. Monitoring and analysis of physiological parameters lead to a better understanding of the adaptation processes. This can help to determine the risk of climate change and its effects on performance characteristics, e.g. milk yield and reproduction. This, in turn, makes it possible to develop effective measures to mitigate the impact of heat load on animals. The aim of this article is to provide an overview of the current literature. Studies especially about the physiological and productive changes due to heat stress in cattle have been summarised in this review. The direction of future research into the aspect of heat stress in cattle is also indicated.
Antimicrobial Susceptibility of Streptococci Most Frequently Isolated from Czech Dairy Cows with Mastitis
Authors: Šlosárková Soňa , Nedbalcová Kateřina , Bzdil Jaroslav , Fleischer Petr , Zouharová Monika , Staněk Stanislav , Kašná Eva , Pechová Alena 
Published: April 2019

Abstract
The aim was to investigate the antimicrobial susceptibility of most frequently isolated streptococci from Czech dairy herds. A total of 3,719 quarter milk samples were collected and cultivated between January 2017 and June 2018 from cows with clinical or subclinical mastitis from 112 farms. Only one isolate of each species, collected from the same farm per six-month period, was included in the susceptibility testing. The susceptibilities of Streptococcus uberis (163 isolates) and S. dysgalactiae (25 isolates) to 10 antimicrobials (penicillin – PEN, amoxicillin/clavulanic acid – AMC, ceftiofur – EFT, clindamycin – CLI, gentamicin – GEN, streptomycin – STR, trimethoprim/sulfamethoxazole – SXT, enrofloxacin – ENR, tetracycline – TET, rifampicin – RIF) from 9 groups were determined by measuring their minimum inhibitory concentrations. The percentages of resistant S. uberis isolates to the antimicrobials were as follows: TET (63.2%), STR (52.1%), CLI (30.1%), and RIF (2.5%). Intermediate susceptibility was found to RIF (63.2%), PEN (35%), ENR (2.5%), EFT (1.8%), and AMC (1.2%). All the S. uberis isolates were susceptible to GEN and SXT (100%). However, only 6.7% of S. uberis isolates were susceptible to all tested antimicrobials, and 38.7% of isolates were multidrug resistant (≥ 3 groups of antimicrobials). All the S. dysgalactiae isolates were susceptible to PEN, AMC, EFT, GEN, SXT, and ENR (100%). Resistant S. dysgalactiae isolates were found to TET (60%), STR (28%), CLI (12%), and intermediate to TET (24%) and RIF (20%). Sixteen percent of S. dysgalactiae isolates were multidrug resistant. The relatively high occurrence of (multiple) resistance, relative to mastitis pathogens, highlights the importance of monitoring this condition in dairy herds.
Effect of Fractionated Seminal Plasma on Sperm Characteristics Following Cryopreservation of Boar Semen
Authors: Wasilewska-Sakowska Karolina , Zasiadczyk Łukasz , Fraser Leyland 
Published: April 2019

Abstract
This study aimed to investigate the effect of fractionated seminal plasma (SP) on boar sperm characteristics following cryopreservation. Gel filtration chromatography yielded two fractions: SP1 with more than 40 kDa (>40 kDa) and SP2 with less than 40 kDa (<40 kDa). The fractionated SP (SP1 and SP2), whole seminal plasma (wSP) and Beltsville Thawing Solution (BTS) were used for the treatment of semen before freezing-thawing. Besides the analysis of sperm motility characteristics, plasma membrane integrity (PMI), acrosome integrity, and viability (Vybrant Apoptosis Assay) were analyzed in pre-freeze and post-thaw (PT) semen. Among the analyzed pre-freeze sperm parameters, rapid movement was markedly affected by boar and treatment. Furthermore, boar and treatment were significant sources of variations in PT semen quality. Treatment with wSP caused a marked reduction in PT semen quality compared with BTS, SP1 or SP2. Wide variations in PT acrosome integrity and viability were observed in spermatozoa treated with BTS and the fractionated SP, being significantly higher in the SP1- and SP2-treated samples. However, PT semen quality did not differ between semen samples treated with SP1 and SP2. Representative electrophoretic profiles of sperm proteins from each treatment showed quantitative and qualitative differences, indicating varying effects of the cryopreservation procedure on the sperm membrane integrity. The findings of this study indicated that the cryoprotective effects of the SP components varied among boars and that different components of the fractionated SP exerted varying effects on sperm functions following cryopreservation. It could be suggested that the variable protective protein components of either fractionated SP ameliorated alterations in the sperm membranes during cryopreservation, resulting in reduced susceptibility to cryo-damage.
Analysis of Genetic Parameters of Carcass Traits and Daily Gain of Native Breed Pigs Raised in Poland
Authors: Szyndler-Nędza Magdalena , Eckert Robert , Tyra Mirosław , Żak Grzegorz , Szulc Karolina , Blicharski Tadeusz 
Published: April 2019

Abstract
The aim of the study was to determine genetic parameters of live performance traits in pigs of three native breeds maintained in Poland. As part of the conservation programmes, the Puławska (Puł), Złotnicka White (ZW) and Złotnicka Spotted (ZS) breeds are monitored for productivity based on performance test results of these breeds. The study included 6042 gilts and 2406 boars of the Puławska breed, 866 Złotnicka White gilts, and 903 Złotnicka Spotted gilts. The genetic parameters were estimated separately for each breed, and also separately for sexes in the case of the Puławska breed. The components (co)variance and genetic parameters were estimated using the REML method for the animal model taking into account different combination of fixed and random effects. Convergence of the iterative process was achieved by the selection of AIREML algorithm. The coefficients of genetic and phenotypic correlations between measurements of slaughter traits and daily gain were low for all breed groups. In turn, the relationships between backfat thickness measurements and carcass meat percentage were estimated as high. Only the correlations of slaughter traits with loin eye height were not uniform for the analysed breed groups. The coefficients of heritability (h2) were high and intermediate for all breeds and sexes. The highest heritability coefficients were obtained for daily gain (0.58 in ZW to 0.80 in Puł gilts), followed by backfat thickness (0.37 in Puł gilts to 0.64 in ZW) and carcass meat percentage (0.40 in ZS to 0.56 in ZW). The lowest coefficients were obtained for loin eye height (0.24 in Puł boars to 0.40 in ZW). The estimated genetic parameters could be used to verify selection indices of the breeds included in the genetic resources conservation programmes.