bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Current‐Adaptive Evaporator with Optimized Energy Utilization for Self‐Cleaning High‐Salinity Desalination
Authors: Zhang Ruicheng , Zhang Wenqing , Ren Haipeng , Liu Keshuai , Yang Shichang , Chen Bin , Li Wei , Ge Can , Xu Duo , Xu Weilin 
Published: November 2024

AbstractSolar steam generation (SSG) shows great potential in brine desalination to address the global water crisis. However, the salt accumulation has become a severe bottleneck that destroys devices and weakens efficiencies. Traditional evaporators are difficult to simultaneously realize clean salt‐rejection and efficient operation during high‐salinity desalination. In this work, a weaved cylinder evaporator with both efficient static and dynamic energy utilization is fabricated for self‐cleaning high‐salinity desalination. The energy utilization performance is optimized through a balanced water supply, omnidirectional solar absorption, infiltration content regulation, and dynamic current adaptation. Hence, an outstanding SSG rate of 1.91 kg·m−2·h−1 is achieved under 1 sun radiation. The dynamic self‐cleaning characteristics ensure competitive and durable high‐salinity desalination (≈11 kg·m−2·day−1) during weekly practical operation without salt deposition. Overall, the design overcomes the trade‐off between desired mass transfer and undesired heat loss.
A Molecular‐Targeting Photosensitizer to Inhibit DNA Damage Repair System and Induce cGAS‐STING Pathway Activation for Photo‐Immunotherapy of Ovarian Cancer
Authors: Fan Lianfeng , Zhang Peng , Gan Yuxuan , Li Ling , Wang Li , Wang Minjia , Liu Xianglong , Ma Jing , Liu Bin , Shi Leilei 
Published: November 2024

AbstractPoly(ADP‐ribose) polymerase (PARP) inhibitors are commonly utilized in the clinical management of patients with platinum‐sensitive recurrent and late‐stage ovarian cancer, which constitutes a significant proportion of gynecological cancer‐related mortality. Nonetheless, the constraints of their monofunctional properties and limited therapeutic efficacy observed in advanced cancer cases necessitate the exploration of more potent therapeutic strategies for the management of ovarian cancer. The present study describes the development of QTABI, a PARP‐targeting photosensitizer capable of producing reactive oxygen species with light irradiation. Simultaneously, it exhibits significant inhibition of PARP activity, induction of deoxyribonucleic acid (DNA) damage, and consequent synthetic lethality. Furthermore, QTABI can effectively promote the accumulation of cytosolic DNA and activate the cyclicGMP‐AMP synthase (cGAS)‐stimulator of interferon gene (STING) pathway under light irradiation, thereby eliciting potent anti‐tumor immune responses and ultimately boosting anti‐cancer efficacy. Collectively, these findings suggest that QTABI is a multi‐functional photosensitizer, which targets the DNA‐damaging repair system and activates the cGAS‐STING pathway, offering a promising combination photo‐immunotherapy strategy for treating ovarian cancer.
Antitumor Activity of a Bispecific Chimera Targeting EGFR and Met in Gefitinib‐Resistant Non‐Small Cell Lung Cancer
Authors: Wang Ya , Zhang Guixi , Zhou Zhilan , Zhang Ning , Jiang Hang , Liu Yichang , Fu Ting , Zhu Yingdi , Li Juan 
Published: November 2024

AbstractNon‐small cell lung cancers (NSCLC) frequently acquire resistance to tyrosine kinase inhibitors (TKI) due to epidermal growth factor receptor (EGFR) mutation or activation of the bypass pathway involving mesenchymal‐epithelial transition factor (Met). To address this challenge, a bispecific nanobody‐aptamer chimera is designed to target mutated EGFR and Met simultaneously to block their cross‐talk in NSCLC. The EGFR‐Met chimera is cost‐effectively engineered using microbial transglutaminase and click chemistry strategies. With enhanced binding affinity toward the target proteins, the as‐developed chimera inhibits efficiently the cross‐talk between signaling pathways associated with EGFR and Met. This inhibition leads to the suppression of downstream pathways, such as Erk and Akt, and induces upregulation of cell cycle arrest‐related proteins, including Rb, p21, and p27. Additionally, the chimera activates the caspase‐dependent apoptotic signaling pathway. Consequently, it inhibits cell migration, induces cell death, and causes cell cycle arrest in vitro. Moreover, the chimera exhibits significant antitumor efficacy in drug‐resistant xenograft mouse models, showcasing improved tissue penetration and low toxicity. This study accentuates the potential of the bispecific EGFR‐Met chimera as a promising therapeutic option for NSCLC resistant to EGFR TKIs.
How the Versatile Self‐Assembly in Drug Delivery System to Afford Multimodal Cancer Therapy?
Authors: Cao Yuqi , Zhao Xiaomin , Miao Yuhang , Wang Xin , Deng Dawei 
Published: November 2024

AbstractThe rapid development of self‐assembly technology during the past few decades has effectively addressed plenty of the issues associated with carrier‐based drug delivery systems, such as low loading efficiency, complex fabrication processes, and inherent toxicity of carriers. The integration of nanoscale delivery systems with self‐assembly techniques has enabled efficient and targeted self‐administration of drugs, enhanced bioavailability, prolonged circulation time, and controllable drug release. Concurrently, the limitations of single‐mode cancer treatment, including low bioavailability, poor therapeutic outcomes, and significant side effects, have highlighted the urgent need for multimodal combined antitumor therapies. Set against the backdrop of multimodal cancer therapy, this review summarizes the research progress and applications of a large number of self‐assembled drug delivery platforms, including natural small molecule self‐assembled, carrier‐free self‐assembled, amphiphilic polymer‐based self‐assembled, peptide‐based self‐assembled, and metal‐based self‐assembled nano drug delivery systems. This review particularly analyzes the latest advances in the application of self‐assembled nano drug delivery platforms in combined antitumor therapies mediated by chemotherapy, phototherapy, radiotherapy, sonodynamic therapy, and immunotherapy, providing innovative research insights for further optimization and expansion of self‐assembled nano drug delivery systems in the clinical translation and development of antitumor combined therapy.
Sustainable Lithography Paradigm Enabled by Mechanically Peelable Resists
Authors: Chen Lei , Liang Huikang , Liu Peng , Liu Cuihong , Feng Bo , Shu Zhiwen , Chen Yiqin , Dong Xiaoqian , Xie Jianfei , Ji Ming , Duan Huigao 
Published: November 2024

AbstractLithography is critical in micro‐ and nanofabrication processes, enabling the development of integrated circuits, semiconductor devices, and various advanced electronic and photonic systems. However, there are challenges related to sustainability, efficiency, and yield, as well as compatibility with transient electronics. This work introduces a sustainable lithography paradigm employing mechanically peelable resists compatible with existing cleanroom processes. The resists exhibit near‐zero adhesion to various substrates, facilitating efficient, cost‐effective, environmentally friendly, and chemical‐free mechanical stripping without observable particulate residues. The mechanical lift‐off process enables scalable and 100%‐yield pattern transfer using commercially available tape within seconds. Furthermore, the new paradigm supports distributed and in situ conformal manufacturing using the peelable resist as a “transferable stencil mask” to fabricate various functional devices on flexible and nonplanar surfaces, as well as ultra‐thin biodegradable substrates. Overall, this work expands the potential for using lift‐off as a standard process in the pan‐semiconductor industry and opens new avenues for lithographic procedures aimed at the reliable mass production of transient electronics and integrated biodegradable devices, addressing growing sustainability issues caused by electronic waste.
Joule‐Heated Interfacial Catalysis for Advanced Electrified Esterification with High Conversion and Energy Efficiency
Authors: Zhang Jifang , Zhang Xinyuan , Shen Yue , Fu Bo , Wu Yijin , Kang Jian , Chen Shan , Wang Guozhong , Zhang Haimin , Yin Huajie , Zhao Huijun 
Published: November 2024

AbstractEsterification reactions are crucial in industries such as chemicals, fragrances, and pharmaceuticals but often face limitations due to high reversibility and low reactivity, leading to restricted yields. In this work, an electrified esterification pathway utilizing a Joule‐heated interfacial catalysis (JIC) system is proposed, where a hydrophilic, sulfonic acid‐functionalized covalent organic framework grown on carbon felt (COF─SO3H@CF) acts as the interfacial catalyst, and the carbon felt serves as the electric heat source. This approach achieves an acetic acid conversion of 80.5% at a heating power density of 0.49 W cm−3, without additional reagents by vaporizing reaction products, surpassing the theoretical equilibrium limit of 62.5% by 1.29 times. Comprehensive analysis indicates that the intimate contact between the electric heat source and the COF─SO3H catalyst enables efficient, localized Joule heating directly at catalytic sites, minimizing thermal losses and allowing precise control over reaction interfaces. This finding demonstrates that this JIC system not only enhances esterification efficiency but may also offer a sustainable, energy‐efficient pathway for high‐yield chemical processes.
A Building‐Integrated Hybrid Photovoltaic‐Thermal (PV‐T) Window for Synergistic Light Management, Electricity and Heat Generation
Authors: Polito Francesco , Huang Gan , Markides Christos N. 
Published: November 2024

AbstractThe installation of common solar panels and collectors in the built environment requires access to significant roof space, which is limited. This motivates the development of high‐efficiency, building‐integrated technologies that can maximize space utilization and energy provision. In this work, a building‐integrated hybrid photovoltaic‐thermal window (PVTW) is fabricated and tested, composed of a semi‐transparent photovoltaic (PV) layer and a selectively absorptive liquid‐based thermal absorber. It is demonstrated that, at 30° inclination, the PVTW can simultaneously generate electricity, with an electrical efficiency of 3.6%, and provide ≈50 °C water, with a thermal efficiency of 10.7%, in the middle of a typical summer day (20th July) in London (maximum ambient temperature ≈34 °C, solar irradiance ≈1100 W m−2 at midday). The water temperature decreases by ≈7 °C, whilst thermal efficiency improves to 17.6% as the inclination angle increases to 90° (vertical); the electrical efficiency reduces marginally (3.3%). Compared to a liquid‐based solar‐thermal window (STW), the PVTW can generate hot water at ≈10 °C higher temperature and with 10% absolute increase in thermal efficiency when the inclination angle is 60°, plus electricity. The wider uptake of this technology in glass‐based urban spaces has the potential to generate significant energy while reducing building temperature management costs.
A Purely Biomanufactured System for Delivering Nanoparticles and STING Agonists
Authors: Li Yu‐an , Feng Yi , Li Wenjing , Zhang Yuqin , Sun Yanni , Wang Shifeng , Curtiss Roy , Shi Huoying 
Published: November 2024

AbstractNanovaccines have significantly contributed in the prevention and treatment of diseases. However, most of these technologies rely on chemical or hybrid semibiological synthesis methods, which limit the manufacturing performance advantages and improved inoculation outcomes compared with traditional vaccines. Herein, a universal and purely biological nanovaccine system is reported. This system integrates three modules: (1) self‐assembling nanoparticles, (2) self‐catalyzed synthesis of small‐molecule stimulator of interferon gene (STING) agonists, and (3) delivery vectors that target the cytosolic surveillance system. Various nanoparticles are efficiently self‐assembled using this system. After confirming the excellent immunostimulatory and lymph node targeting of this system, its broad‐spectrum antiviral efficacy is further demonstrated. By leveraging the comprehensive biosynthetic capabilities of bacterial cells, this system can efficiently combine various adjuvant‐active modular components and antigenic cargo, thereby providing a highly diversified and potent vaccine platform.
Implantable Multifunctional Micro‐Oxygen Reservoir System for Promoting Vascular‐Osteogenesis via Remodeling Regenerative Microenvironment
Authors: Rui Min , Mao Jiannan , Wu Hongshuai , Hui Yujian , Shen Hao , Yang Yilin , Ma Tao , Ren Kewei , Wang Juan , Cui Wenguo , Shi Qin , Yang Huilin 
Published: November 2024

AbstractHypoxia and reactive oxygen species (ROS) overaccumulation cause persistent oxidative stress and impair intrinsic regenerative potential upon tissue injury. For local tissue injury with hypoxia, such as bone fracture and defects, a localized‐sufficient oxygen supply is highly desirable but remains challenging. Therefore, to explore a strategy and its intrinsic mechanism for supplying oxygen locally and remodeling the regenerative microenvironment, an innovative oxygenating hydrogel microsphere system with sustained oxygenation and antioxidant properties is introduced by loading CaO2@SiO2@PDA (CSP) nanoparticles. Specifically, the CSP nanoparticles exhibited broad‐spectrum free radicals scavenging ability, along with prolonged controlled‐release of oxygen once integrated into the gelatin methacrylate anhydride (GelMA) microspheres (CSP‐GM). The CSP‐GM with extra cellular matrix (ECM)‐mimicking structures reconstructed living niches, promoting the adhesion and proliferation of bone marrow stromal cells (BMSCs). As a multifaceted microenvironment regulator, CSP‐GM remodeled the regenerative microenvironment by synergistically producing oxygen and scavenging ROS, recovering mitochondrial homeostasis and antioxidant defenses of BMSCs, promoting angiogenesis and osteogenesis under hypoxia conditions via precisely modulating the Nrf2/HO‐1 signaling pathway. The multiple pro‐regenerative effects of the implantable functionalized micro‐oxygen reservoir on bone repair are further corroborated by the enhanced vascularized bone formation in rat femoral defects, presenting a comprehensive and promising strategy for tissue repair.
Metamaterial‐Enabled Hybrid Receive Coil for Enhanced Magnetic Resonance Imaging Capabilities
Authors: Zhu Xia , Wu Ke , Anderson Stephan W. , Zhang Xin 
Published: November 2024

AbstractMagnetic resonance imaging (MRI) relies on high‐performance receive coils to achieve optimal signal‐to‐noise ratio (SNR), but conventional designs are often bulky and complex. Recent advancements in metamaterial technology have led to the development of metamaterial‐inspired receive coils that enhance imaging capabilities and offer design flexibility. However, these configurations typically face challenges related to reduced adaptability and increased physical footprint. This study introduces a hybrid receive coil design that integrates an array of capacitively‐loaded ring resonators directly onto the same plane as the coil, preserving its 2D layout without increasing its size. Both the coil and metamaterial are individually non‐resonant at the targeted Larmor frequency, but their mutual coupling induces a resonance shift, achieving a frequency match and forming a hybrid structure with enhanced SNR. Experimental validation on a 3.0 T MRI platform shows that this design allows for adjustable trade‐offs between peak SNR and penetration depth, making it adaptable for various clinical imaging scenarios.
Mechanical Activation of cPLA2 Impedes Fatty Acid β‐Oxidation in Vein Grafts
Authors: Fan Linwei , Tang Yuanjun , Liu Jian , Liu Yueqi , Xu Yiwei , Liu Jiayu , Liu Han , Pang Wei , Guo Yuxuan , Yao Weijuan , Zhang Tao , Peng Qin , Zhou Jing 
Published: November 2024

AbstractHigh‐magnitude cyclic stretch from arterial blood pressure significantly contributes to the excessive proliferation and migration of vascular smooth muscle cells (VSMCs), leading to neointima formation in vein grafts. However, the molecular mechanisms remain unclear. This study highlights the critical role of cytosolic Phospholipase A2 (cPLA2)/ Yin Yang 1 (YY1)/ carnitine palmitoyltransferase 1b (CPT1B) signaling in coordinating VSMC mechanical activation by inhibiting fatty acid β‐oxidation. Metabolomic analysis showed that a 15%–1 Hz arterial cyclic stretch, compared to a 5%–1 Hz venous stretch, increased long‐chain fatty acids in VSMCs. cPLA2, identified as a mechanoresponsive molecule, produces excessive arachidonic acid (ArAc) under the 15%–1 Hz stretch, inhibiting CPT1B expression, a key enzyme in fatty acid β‐oxidation. ArAc promotes transcription factor YY1 degradation, downregulating CPT1B. Inadequate fatty acid oxidation caused by knockdown of CPT1B or YY1, or etomoxir treatment, increased nuclear membrane tension, orchestrating the activation of cPLA2. Overexpressing CPT1B or inhibiting cPLA2 reduced VSMC proliferation and migration in vein grafts, decreasing neointimal hyperplasia. This study uncovers a novel mechanism in lipid metabolic reprogramming in vein grafts, suggesting a new therapeutic target for vein graft hyperplasia.
Enhancing the Therapeutic Potential of Peptide Antibiotics Using Bacteriophage Mimicry Strategies
Authors: Wan Hongping , Zhong Xinyi , Yang Shinong , Deng Jiarong , Song Xu , Liu Yong , Li Yuanfeng , Yin Zhongqiong , Zhao Xinghong 
Published: November 2024

AbstractThe rise of antibiotic resistance, coupled with a dwindling antibiotic pipeline, presents a significant threat to public health. Consequently, there is an urgent need for novel therapeutics targeting antibiotic‐resistant pathogens. Nisin, a promising peptide antibiotic, exhibits potent bactericidal activity through a mechanism distinct from that of clinically used antibiotics. However, its cationic nature leads to hemolysis and cytotoxicity, which has limited its clinical application. Here, nanodelivery systems have been developed by mimicking the mechanisms bacteriophages use to deliver their genomes to host bacteria. These systems utilize bacteriophage receptor‐binding proteins conjugated to loading modules, enabling efficient targeting of bacterial pathogens. Peptide antibiotics are loaded via dynamic covalent bonds, allowing for infection microenvironment‐responsive payload release. These nanodelivery systems demonstrate remarkable specificity against target pathogens and effectively localize to bacteria‐infected lungs in vivo. Notably, they significantly reduce the acute toxicity of nisin, rendering it suitable for intravenous administration. Additionally, these bacteriophage‐mimicking nanomedicines exhibit excellent therapeutic efficacy in a mouse model of MRSA‐induced pneumonia. The facile synthesis, potent antimicrobial performance, and favorable biocompatibility of these nanomedicines highlight their potential as alternative therapeutics for combating antibiotic‐resistant pathogens. This study underscores the effectiveness of bacteriophage mimicry as a strategy for transforming peptide antibiotics into viable therapeutics.
Modulating the Interactions of Peptide‐Polyphenol for Supramolecular Assembly Coatings with Controllable Kinetics and Multifunctionalities
Authors: Huo Kaiyuan , Liu Wenjie , Shou Zeyu , Wang Hongxiang , Liu Hao , Chen Yang , Zan Xingjie , Wang Qing , Li Na 
Published: November 2024

AbstractPolyphenols and peptides represent two fundamental building blocks in the kingdom of supramolecular assembly (SA) coatings, which have recently attracted considerable interest. Regulating the assembly kinetics of SA coatings is critical to controlling the performance of SA coatings, but this area is still in its infancy, especially in the SA coating of peptide‐polyphenol. Herein, a library of oligopeptides with rich diversity, numerous polyphenols, and modulators are explored to reveal their roles in the formation and regulation of SA coating. Citric acid (CA) is an effective regulator of interaction between the polyphenols and peptides to produce peptide‐polyphenol coatings, TCP. The electrostatic interaction between tannic acid (TA) and cationic peptide drives the formation of TCP, while the multiple hydrogen bonds between CA and TA and peptide dominate the assembly kinetics. With optimized assembly pH and the mass ratio of TA, CA, and peptide, the thickness of TCP coating deposits onto diverse substrates (glass, silica, titanium, polystyrene) is ≈400 nm with controllable kinetics. The multifunctional TCP coatings are endowed via peptide‐coupled functional units, including enhanced cellular adhesion, elevated osteogenic capacity, anti‐protein adsorption, and antimicrobial. This work contributes to the understanding of the assembly kinetics and functionalization of peptide‐polyphenol coatings.
Boosting Li‐Metal Anode Performance with Lithiophilic Li–Zn Seeds in a 2D Reduced Graphene Oxide Scaffold
Authors: Zhou Xiaoze , Wang Shuaiqi , Li Yaru , Yang Yi , Xiao Xiao , Chen Gang 
Published: November 2024

AbstractThe substitution of conventional graphite with Li metal as an anode material has garnered significant interest due to its exceptionally high theoretical energy density. However, the direct application of Li metal as an anode in batteries faces formidable challenges, including dendrite growth and interphase instability. Herein, a high‐performance composite anode (LZ‐rGO) that integrates a reduced graphene oxide (rGO) scaffold with lithiophilic Li–Zn alloy nanoparticles is presented. The Li–Zn seeds embedded in the structure lower the initial nucleation barrier and facilitate uniform Li deposition. Furthermore, the rGO scaffold, possessing a large specific surface area, enables the LZ‐rGO anode to significantly reduce voltage hysteresis and prevents the deactivation of metallic Li during the plating/stripping processes. As a result, the symmetric cell demonstrates stability over 1200 h at a current density of 1 mA cm−2, with negligible voltage fluctuation. When paired with a LiFePO4 cathode, the full cell achieves stable cycling for 1000 cycles with a high‐capacity retention, demonstrating exceptional interface stability and cycling efficiency.
Boosting electrocatalytic alcohol oxidation: Efficient d–π interaction with modified TEMPO and bioinspired structure
Authors: Chen Ying , Wang Shibin , Xu Zaixiang , Wang Yuhang , He Jiahui , Li Kai , Wang Jieyu , Liu Lihao , Ren Linhan , Li Suiqin , Zhang Zhengbin , Zhong Xing , Wang Jianguo 
Published: November 2024

AbstractAminoxyl radicals electrocatalysis presents a sustainable method for oxidizing alcohols into high‐value products. Nonetheless, the requirement for high doses of aminoxyl radicals diminishes product purity and economic viability. This study synthesized methylimidazole‐functionalized 4‐acetylamino‐2,2,6,6‐tetramethylpiperidine‐N‐oxyl derivative (MIAcNH‐TEMPO) with a strongly electron‐withdrawing imidazole group and combined it with bioinspired nickel‐supported carbonaceous octopus tentacles for effective electrooxidation of alcohols, achieving high current density of 200 mA cm−2, selectivity of 99%, and turnover frequency of 26,490 h−1. In situ experiments and theoretical calculations indicated that the synergistic effect of Ni‐3dxz orbitals on the tentacle surface interacting with the π orbitals of MIAcNH‐TEMPO creates a strong d–π interaction, which effectively facilitating the creation of a locally intermediate‐enriched microenvironment, decreased the required quantity of aminoxyl radicals. Moreover, the high aqueous solubility of MIAcNH‐TEMPO reduces the difficulty of separation process. Scale‐up experiments conducted in a continuous flow electrolyzer showcased the potential of this strategy for practical applications.