bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prevalence and adverse obstetric outcomes of female genital mutilation among women in rural Northern Ghana
Authors: Nonterah Engelbert A , Kanmiki Edmund W , Agorinya Isaiah A , Sakeah Evelyn , Tamimu Mariatu , Kagura Juliana , Kaburise Michael B , Ayamba Emmanuel Y , Nonterah Esmond W , Awuni Denis A , Al-Hassan Majeedallahi , Ofosu Winfred , Awoonor-Williams John K , Oduro Abraham R 
Published: October 2019

Abstract

Background
Female genital mutilation (FGM) is commonly practiced in sub-Saharan Africa and results in adverse pregnancy outcomes among affected women. This paper assessed the prevalence and effects of FGM on pregnancy outcomes in a rural Ghanaian setting.

Methods
We analyzed 9306 delivery records between 2003 and 2013 from the Navrongo War Memorial Hospital. Multivariable logistic regression analyses were used to determine the effects of FGM on pregnancy outcomes such as stillbirth, birth weight, postpartum haemorrhage, caesarean and instrumental delivery. We also assessed differences in the duration of stay in the hospital by FGM status.

Results
A greater proportion of mothers with FGM (24.7%) were older than 35 years compared with those without FGM (7.6%). FGM declined progressively from 28.4% in 2003 to 0.6% in 2013. Mothers with FGM were nearly twice as likely to have caesarean delivery (adjusted odds ratios = 1.85 with 95%CI [1.72, 1.99]) and stillbirths (1.60 [1.21, 2.11]) compared with those without. Similarly, they had a 4-fold increased risk of post-partum haemorrhage (4.69 [3.74, 5.88]) and more than 2-fold risk lacerations/episiotomy (2.57 [1.86, 3.21]) during delivery. Average duration of stay in the hospital was higher for mothers with FGM from 2003 to 2007.

Conclusions
Despite significant decline in prevalence of FGM, adverse obstetric outcomes are still high among affected women. Increased public health education of circumcised women on these outcomes would help improve institutional deliveries and heighten awareness and prompt clinical decisions among healthcare workers. Further scale-up of community level interventions are required to completely eliminate FGM.
Cell-fies: sharing microbiology with global audiences through Instagram
Authors: Hines Hunter N 
Published: October 2019

ABSTRACT
For the dissemination of microbiology and science in general, social media is an underutilized but increasingly powerful tool, and one that transcends traditional avenues for scientific outputs. In order to reach and potentially inspire a deeply interested and general public, scientists should engage with platforms such as Instagram to share their content to an increasingly global audience.
Physical Functional Limitations in a First-Admission Cohort at Midlife: Findings From the Suffolk County Mental Health Project
Authors: Clouston Sean A P , Jonas Katherine , Fochtmann Laura J , Bromet Evelyn J , Kotov Roman 
Published: October 2019

Abstract

Background
Psychosis is a risk factor for aging-related conditions and early mortality. Little is known about the age-specific risk of objectively measured physical functional limitations among individuals with serious mental illness.

Methods
The Suffolk County Mental Health Project is a prospective study of individuals hospitalized for the first time for psychosis. To assess physical functioning at midlife and to identify emerging risk factors for older-age changes, 101 participants with schizophrenia (mean age = 47.2, SD = 8.0 years; 41.6% female) and 112 participants with other psychoses (mean age = 48.2, SD = 9.5 years; 45.5% female) were assessed for chair-rise and balance limitations 20 years after diagnosis. A never-psychotic comparison group of 237 age/sex/geographically matched community controls was similarly assessed (mean age = 50.3, SD = 8.8 years; 44.7% female). Logistic regression was used to examine group differences in prevalence of poor performance and demographic, medical, and treatment correlates.

Results
Chair-rise limitations (45.5% [35.8–55.3]) and balance limitations (17.2% [9.8–24.5]) were common in individuals with schizophrenia. Prevalence of chair-rise limitations was higher in schizophrenia (46.3%) than in other psychotic disorders (31.9%) and never-psychotic group (22.1%), whereas risk of balance limitations was higher in schizophrenia (17.2%) compared with never-psychotic controls (8.1%). Schizophrenia was a significant risk factor for chair-rise (adjusted odds ratio = 3.01 [1.79–5.08], p &lt; .001) and balance limitations (adjusted odds ratio = 2.63, [1.25–5.51], p = .010). Multivariable analysis of symptom severity found avolition was associated with chair-rise limitations, but not balance, independent of diagnosis.

Conclusion
Physical limitations are crucial because they identify existing problems with mobility and portend an increased risk of disability and death. Because participants with schizophrenia were at increased risk of physical limitations, assessments of chair-rise and balance limitations may be critical to monitoring individuals with psychosis.
IKAP—Identifying K mAjor cell Population groups in single-cell RNA-sequencing analysis
Authors: Chen Yun-Ching , Suresh Abhilash , Underbayev Chingiz , Sun Clare , Singh Komudi , Seifuddin Fayaz , Wiestner Adrian , Pirooznia Mehdi 
Published: October 2019

Abstract

Background
In single-cell RNA-sequencing analysis, clustering cells into groups and differentiating cell groups by differentially expressed (DE) genes are 2 separate steps for investigating cell identity. However, the ability to differentiate between cell groups could be affected by clustering. This interdependency often creates a bottleneck in the analysis pipeline, requiring researchers to repeat these 2 steps multiple times by setting different clustering parameters to identify a set of cell groups that are more differentiated and biologically relevant.

Findings
To accelerate this process, we have developed IKAP—an algorithm to identify major cell groups and improve differentiating cell groups by systematically tuning parameters for clustering. We demonstrate that, with default parameters, IKAP successfully identifies major cell types such as T cells, B cells, natural killer cells, and monocytes in 2 peripheral blood mononuclear cell datasets and recovers major cell types in a previously published mouse cortex dataset. These major cell groups identified by IKAP present more distinguishing DE genes compared with cell groups generated by different combinations of clustering parameters. We further show that cell subtypes can be identified by recursively applying IKAP within identified major cell types, thereby delineating cell identities in a multi-layered ontology.

Conclusions
By tuning the clustering parameters to identify major cell groups, IKAP greatly improves the automation of single-cell RNA-sequencing analysis to produce distinguishing DE genes and refine cell ontology using single-cell RNA-sequencing data.
Efficacy and safety of surgery for spontaneous pneumothorax in elderly patients
Authors: Nagata Shunichi , Omasa Mitsugu , Tokushige Kosuke , Nakanishi Takao , Motoyama Hideki 
Published: October 2019

Abstract

OBJECTIVES
There is no clear consensus on the surgical indications for spontaneous pneumothorax in elderly patients. In this study, we aimed to assess the efficacy and safety of surgical treatment of spontaneous pneumothorax in patients aged ≥70 years. We also sought to identify the risk factors for postoperative prolonged air leaks and complications in such patients.

METHODS
Data pertaining to 104 elderly patients who underwent surgery out of 206 patients (aged ≥70 years) who were diagnosed with spontaneous pneumothorax at our institution between 1994 and 2018 were retrospectively reviewed. The incidences of postoperative persistent air leaks (≥2 days) and postoperative complications (≥grade 3; Clavien–Dindo classification) were analysed for efficacy and safety assessment, respectively.

RESULTS
Median postoperative air leaks continued for 0 days (range 0–25); 14.4% patients developed ≥grade 3 postoperative complications. On the basis of results of multivariable analysis, it was observed that a higher PaCO2 level was significantly associated with prolonged postoperative air leaks [odds ratio (OR) 1.08, 95% confidence interval (CI) 1.00–1.17; P = 0.047]. Poorer performance status was associated with a significantly increased risk of postoperative complications, as assessed by multivariable analysis (OR 6.13, 95% CI 1.38–27.3; P = 0.017). The recurrence rate was 4.8%; mortality rate of patients was 2.9%. Three-year survival rate after surgery was 73.8%.

CONCLUSIONS
Surgical treatment of spontaneous pneumothorax may be effective and safe in selected elderly patients. Moreover, higher PaCO2 and poorer performance status were independent risk factors for postoperative persistent air leaks and complications, respectively.
Cumulative sum analysis of the learning curve for the preclosure technique using Proglide
Authors: Gao Haoyu , Luo Mingyao , Fang Kun , Fan Bowen , Zhao Jiawei , Xue Yunfei , Shu Chang 
Published: October 2019

Abstract

OBJECTIVES
Our study aims to assess the technical quality and the learning curve of the preclosure technique for a vascular surgeon using Proglide using cumulative sum analysis (CUSUM analysis).

METHODS
This study was designed retrospectively and enrolled 81 consecutive patients with 88 access sites who underwent endovascular aortic repair or thoracic endovascular aortic repair with the preclosure technique using Proglide between July 2017 and February 2018. The patients were divided into 2 groups chronologically: (A) the first 40 cases and (B) the latter 41 cases. Logistic regression analysis was used to assess the impact of technical risk factors on the success of the preclosure technique, and the χ2 test and 1-way ANOVA were applied to analyse the distribution of individual characteristics and risk factors between the 2 groups. CUSUM analysis was adapted to analyse the learning curve and to monitor the technical quality, with a predetermined target failure rate of 5%, an alternative failure rate of 20% and calculated 80% ‘alert’, 95% ‘alarm’ and 80% ‘reassurance’ lines.

RESULTS
Primary technical success was obtained in 81 (92.05%) access sites. There were no significant correlations between primary technical success and risk factors, including, common femoral artery diameter (P = 0.88), common femoral artery depth from the skin (P =0.94), the level of common femoral artery calcification (P =0.86) and size of sheath (P =0.96). Moreover, the distribution of related risk factors was not significantly different between groups A and B. CUSUM analysis showed that the cumulative failure rate never crossed the 80% ‘alert’ and 95% ‘alarm’ lines. Additionally, the failure rate began to approach the 80% ‘reassurance’ line after ∼22 cases and crossed the 80% ‘reassurance’ line after 36 cases.

CONCLUSIONS
The technique of totally percutaneous access using Proglide is safe and effective for an experienced vascular surgeon, even if the operator has no previous experience with any preclosure techniques. CUSUM analysis showed that 36 cases are necessary to achieve the target failure rate of 5%.
Key aspects and feasibility assessment of a proposed wind farm in Jordan
Authors: Al-Addous Mohammad , Saidan Motasem , Bdour Mathhar , Dalala Zakariya , Albatayneh Aiman , Class Christina B 
Published: October 2019

AbstractTo tackle climate change and secure energy supplies, many countries invest heavily on wind energy as it is a clean source and is becoming more cost effective with the technological advancement and increased capacity per unit installed. The investigation of the availability of wind resources is an essential step of any feasibility study of a wind farm project and is vital for securing financial resources. With this intent, the main aspects for designing a wind farm at Ajloun (north of Jordan) is investigated and wind energy potential is determined based on available wind data. Based on the site characteristic, the required infrastructure is highlighted, including the turbine array layout and the pattern of connections with the external transmission lines. The investigation of the feasibility of the project includes an appraisal of social and environmental consequences of constructing the wind farm project. The results show that the selected location for the wind farm is encouraging and has a promising profit potential. The findings estimate the annual electricity generation of the wind farm at 379659.51 MWh, with a breakeven selling point of around $30.03/MWh, at a highly competitive price. However, with an estimated selling price of $36.65/MWh on average, it will settle the interest rate demanded by the banks that have an internal rate of return of 7%. No major issues with geotechnical and environmental issues were identified with respect to the project.
Ulrich Bundles on Three-Dimensional Scrolls
Authors: Fania Maria Lucia , Lelli-Chiesa Margherita , Pons-Llopis Joan 
Published: October 2019

AbstractIn this paper we construct Ulrich bundles of low rank on three-dimensional scrolls (with respect to the tautological line bundle). We pay special attention to the four types of three-fold scrolls in ${\mathbb{P}}^5$, which were classified in [31].
The Use of Large-Particle Aerosol Exposure to Nipah Virus to Mimic Human Neurological Disease Manifestations in the African Green Monkey
Authors: Lee Ji Hyun , Hammoud Dima A , Cong Yu , Huzella Louis M , Castro Marcelo A , Solomon Jeffrey , Laux Joseph , Lackemeyer Matthew , Bohannon J Kyle , Rojas Oscar , Byrum Russ , Adams Ricky , Ragland Danny , St Claire Marisa , Munster Vincent , Holbrook Michael R 
Published: October 2019

Abstract
Nipah virus (NiV) is an emerging virus associated with outbreaks of acute respiratory disease and encephalitis. To develop a neurological model for NiV infection, we exposed 6 adult African green monkeys to a large-particle (approximately 12 μm) aerosol containing NiV (Malaysian isolate). Brain magnetic resonance images were obtained at baseline, every 3 days after exposure for 2 weeks, and then weekly until week 8 after exposure. Four of six animals showed abnormalities reminiscent of human disease in brain magnetic resonance images. Abnormalities ranged from cytotoxic edema to vasogenic edema. The majority of lesions were small infarcts, and a few showed inflammatory or encephalitic changes. Resolution or decreased size in some lesions resembled findings reported in patients with NiV infection. Histological lesions in the brain included multifocal areas of encephalomalacia, corresponding to known ischemic foci. In other regions of the brain there was evidence of vasculitis, with perivascular infiltrates of inflammatory cells and rare intravascular fibrin thrombi. This animal model will help us better understand the acute neurological features of NiV infection and develop therapeutic approaches for managing disease caused by NiV infection.
Governing ignorance through abduction
Authors: Magnani Lorenzo 
Published: October 2019

AbstractI will analyse three fundamental ways of governing ignorance though abduction, which are essential from an eco-cognitive and eco-logical point of view, in which the central role in human cognition of natural and artefactual environment is taken into account. First of all, according to the so-called GW-schema, proposed by Gabbay and Woods, abduction presents an ignorance-preserving or (ignorance-mitigating) character: given the fact that the abduced hypotheses aim at becoming truths, the basic ignorance is neither solved nor left untouched. Second, I will contend that abduction is not always ignorance preserving but also knowledge enhancing. Indeed, according to the eco-cognitive model of abduction, I myself have recently proposed, we can easily see that, occasionally, knowledge can be immediately increased (and ignorance ‘killed’) through abduction: in this perspective, abduction does not have to be rigidly conceptualized as an inference to the best explanation in the received sense, which is as an inference that, to grant truth, also takes advantage of an empirical evaluation phase or an inductive phase, as Peirce classified it. Finally, it is important to stress that abductive cognition is at the roots of two fundamental cognitive processes. On one side, abductive cognition constructs (and/or takes advantage of the exploitation of) embodiments, external representations, enactions, artefacts and props, which involve ignorant entities suitably transformed in cognitive representations and/or devices. On the other side, abductive cognition dominates those ‘special’ cognitive creative processes that lead to what I call the disseminated ‘computational domestication of ignorant entities’: I will illustrate the example of the recent unconventional computational domestication of ignorant entities, which creates novel cognitive embodiments (morphological computation).
Probability as a modal operator: the possibilities of its combination with other modalities
Authors: Guallart Nino 
Published: October 2019

Abstract
In this work we examine some of the possibilities of combining a simple probability operator with other modal operators, in particular with a belief operator. We will examine the semantics of two possible situations for expressing probabilistic belief or the lack of it, a simple subjective probability operator (SPO) versus the composition of a belief operator, plus an objective modal operator (BOP). We will study their interpretations in two probabilistic semantics: a relational Kripkean one and a variation of neighbourhood semantics, showing that the latter is able to represent the lack of probabilistic belief more directly, just with the SPO, whereas relational semantics needs the combination of BOP probability to represent lack of belief.
Growth of the tropical Pinus kesiya as influenced by climate and nutrient availability along an elevational gradient
Authors: Ho Le Tuan , Schneider Raimund , Thomas Frank M 
Published: October 2019

Abstract

Aims
In contrast to temperate regions, the reasons for growth reductions of individual tree species along elevational gradients in tropical mountain ranges are poorly known, especially for tropical conifers. We aimed at testing whether climatic or edaphic conditions are responsible for the reduced growth of Pinus kesiya, a widely distributed pine species of southern and south-eastern Asia, at higher elevations.

Methods
We analysed the stem diameter increment and the isotope discrimination against 13C (△ 13C) in tree rings of P. kesiya along an elevational gradient of ~900 to ~2000 m a.s.l. in the mountain ranges of South-Central Vietnam, and related growth to △  13C and to climatic and edaphic variables.

Important findings
We found no consistent correlation patterns between the basal area increment (BAI) of the trees and temperature or precipitation. In contrast, across the elevational gradient, we obtained significantly negative correlations of BAI with △  13C and with the C/N ratios and the δ 15N signature of the upper mineral soil. BAI was positively correlated with the concentrations of plant-available phosphorus (Pa) and of “base” cations (calcium, magnesium, potassium) in the soil. We conclude that lower temperatures at higher elevations exert an indirect effect on tree growth by inducing higher C/N ratios and by reducing the rate of nitrogen (N) and P mineralization, which may be further hampered by lower concentrations of “base” cations (upon enhanced leaching by precipitation) and a negative feedback from low availability of mineralized N and P at higher elevations. Our results may be transferable to the uppermost growth limit of P. kesiya and to other montane regions of the species’ occurrence.
Benign Pancreatic Hyperenzymemia, Also Known as Gullo’s Syndrome
Authors: Rosell-Camps Antonio , Martínez-Cepas Patricia , Riera-Llodrá Joana María , Ventura-Espejo Laura , Riutord-Arrom Nadal 
Published: October 2019

Abstract
Benign pancreatic hyperenzymemia, also known as Gullo’s syndrome, is a little-known syndrome first described in 1996 in patients studied for an elevation of pancreatic enzymes while otherwise being asymptomatic. We describe the case of a 2-year-old patient who was found to have significant elevation of amylase and lipase levels while he was asymptomatic. Blood tests and imaging tests were performed to determine the etiology, but they gave normal results. The enzyme elevation can even be 10 times the normal value of the enzyme, and only 1 enzyme may elevate, although most often all pancreatic enzymes are elevated. The etiology is not known, although several hypotheses have been suggested. This enzyme elevation is described both in adults and children and also sporadically or with a familial pattern. Knowledge of it can limit the performance of the multiple complementary test, some of which are very invasive in patients who have elevated pancreatic enzymes while they are asymptomatic. It knowledge allows us to confirm a benign prognosis about it and reassure the family about this disease and that in the end it will not require aggressive treatments such as surgery or chemotherapy.
Towards 3D modelling of convection in planetesimals and meteorite parent bodies
Authors: Neumann Wladimir 
Published: October 2019

ABSTRACT
Observations of asteroid belt members, investigations of meteorites and thermal evolution models converge on the paradigm of the ubiquity of melting processes in the planetesimals of the early Solar system. At least partial melting of planetesimals that fulfilled size and accretion time requirements to surpass the solidus temperatures of metal and silicates led to the weakening of the rock due to the interstitial melt. A decrease of the viscosity relative to melt-free material facilitates solid-state convection on partially molten bodies. Additional melting can produce liquid-like layers with suspended particles, i.e. magma oceans. Thermal evolution models indicate that partially molten layers can occur in the interior of undifferentiated bodies and in silicate mantles of differentiated ones. They can exist before a magma ocean forms or after it solidifies and above a whole-mantle magma ocean or below a shallow magma ocean. Thus, convection is likely. Attempts to model and to quantify the effects of convection in planetesimals remain rare. This study discusses the possibility of solid-state convection in partially molten planetesimals, presents a first-order comparison of a 3D mantle convection model with a conduction model taking a Vesta-sized body as an example and illustrates the importance of convection for meteorite parent bodies.
Tomopeas ravus (Chiroptera: Molossidae)
Authors: Velazco Paúl M , Kline Kerry A 
Published: October 2019

Abstract
Tomopeas ravus Miller, 1900 is a bat commonly called Peruvian crevice-dwelling bat. It is the only representative of the subfamily Tomopeatinae and endemic to the coastal desert of Peru where it is associated with woody savanna ecosystems and narrow rock crevices. Globally, it is considered “Endangered” by the International Union for Conservation of Nature and Natural Resources, mostly due to the ongoing population reduction and small and fragmented geographic range.