bluuebunny/crossref_metadata_2025_split huggingface dataset:
Patient participation, authority and understanding – A case study of communication patterns in a geriatric consultation
Authors: Hellström Muhli Ulla , Saferstein Barry , Siouta Eleni 
Published: August 2019

Objectives: The objectives are to examine communication patterns in the discourse between a female geriatric patient and a pharmacist concerning use of an inhaler in order to understand the communicative components of consultation interaction that support the patient learning and demonstrate understanding of medical information. Methods: This article is a qualitative case study from a project that video recorded 40 clinical consultations. The case was selected as a representative example of the use of material and visual information resources during a clinical consultation between a patient and a pharmacist in a geriatric setting. Results: The patient's understanding of the clinician's medical advice did not result simply from repeating the clinician's demonstration. Rather, the patient's discussion and manipulation of the inhaler produced a communication pattern that increased her authority over topics and forms of expression. Conclusion: A combination of verbal, visual and tactile information resources produced pattterns of interaction that enhanced the patient's participation, authority and understanding of medical information. Practice implications: Many consultations can incorporate use of visual and material information resources to improve patients’ participation in treatment decisions.
Contemporary Outcomes for Advanced-Stage Classical Hodgkin Lymphoma in the U.S.: Analysis of Surveillance, Epidemiology, and End Results Database
Authors: Guru Murthy Guru Subramanian , Szabo Aniko , Hamadani Mehdi , Fenske Timothy S. , Shah Nirav N. 
Published: August 2019

Abstract

Background
Advanced-stage Hodgkin lymphoma (HL) is a curable malignancy, although outcomes remain poor in certain patients. It remains unclear if recent advances have improved their population-level survival over time.

Materials and Methods
Using the Surveillance, Epidemiology, and End Results database, we identified patients aged ≥18 years with stage III or IV classical HL as the first primary malignancy, diagnosed between 2000 and 2014 and treated with chemotherapy. Patients were stratified by date of diagnosis into three groups (2000–2004, 2005–2009, 2010–2014) to assess the trends in overall survival (OS).

Results
A total of 9,042 patients with a median age of 41 years were included. The use of frontline radiation therapy decreased in each period (21.3% [2000–2004] vs. 15.5% [2005–2009] vs. 10.7% [2010–2014]; p &lt; .001). Three-year OS was significantly higher for patients diagnosed between 2010 and 2014 (81.8%) and 2005 and 2009 (80.6%) compared with 2000 and 2004 (78.5%; p = .0008 and .02, respectively). Whereas outcomes were poorest in the age &gt;60 cohort, similar improvements were also seen in 3-year OS over the three time periods within this patient population. On multivariate analysis, diagnosis in the earlier period and minority race were associated with higher mortality. Females and married patients had significantly lower mortality risk.

Conclusion
Survival of patients with advanced-stage HL has continued to improve over time, suggesting the impact of evolving treatment approaches. Three-year OS in the contemporary period remains inadequate at 81.8%, highlighting the need for continued research to improve their outcomes.

Implications for Practice
This article evaluates contemporary outcomes for advanced-stage Hodgkin lymphoma (HL) in the U.S. using the Surveillance, Epidemiology, and End Results database. Although overall survival (OS) has improved in each 5-year period since 2000, the 3-year OS from 2010 to 2014 remains inadequate at 81.8% and is limited by patient demographics. New therapies are indicated to improve clinical outcomes in advanced-stage HL.
A perda urinária é frequente em pacientes com Doença Pulmonar Obstrutiva Crônica (DPOC) atendidos ambulatorialmente
Authors: Correia da Silva Carolina , Ribeiro Santana Júlia , Oliveira da Silva Vinícius , Godoy Januário Priscila , França Ferraz de Oliveira Humberto , Camelier Aquiles Assunção , Rosa Camelier Fernanda Warken 
Published: August 2019

INTRODUÇÃO: A incontinência urinária (IU) é definida como qualquer perda involuntária de urina, sendo a tosse um fator de risco. A tosse é um sintoma frequente da Doença Pulmonar Obstrutiva Crônica (DPOC) podendo associar-se com a IU. OBJETIVO: Avaliar a frequência de perda urinária e o impacto da IU na qualidade de vida das pessoas com DPOC e caracterizar a presença de tosse. MATERIAL E MÉTODOS: Tratou-se de um estudo descritivo, realizado em pessoas com DPOC. A coleta dos dados foi realizada no Departamento de Ciências da Vida II/UNEB. Aplicou-se o International Consultation Incontinence Short-Form (ICIQ-SF) para avaliar a frequência de perda urinária e o King’s Health Questionnaire (KHQ) para o impacto na qualidade de vida. Os dados foram analisados no software SPSS (v.22.0), descritos em medida de tendência central, dispersão e proporções. Um p < 0,05 foi considerado estatisticamente significante. RESULTADOS: Das 30 pessoas avaliadas, a média da idade foi 66,7± 8,6 anos; desses 11 (36,7%) apresentaram queixa de IU, sendo sete (63,3%) mulheres. Entre esses a média de pontuação do ICIQ-SF foi de 5,9± 4,4. Vinte e oito participantes (93,3%) tinham tosse crônica. Analisando o KHQ, o domínio de maior impacto foi “percepção geral de saúde’’. CONCLUSÃO: A frequência de IU em pessoas com DPOC foi de 35,7% e a de tosse foi de 93,3%. Entre as pessoas com perda urinária, 36,7% referiram alguma interferência na vida diária. É importante incluir a avaliação da IU para ampliar o manejo clínico da condição de saúde dessas pessoas.
LA EMPRESA ESTATAL COMO TERCERO CIVIL A PROPÓSITO DEL PERFECCIONAMIENTO DE LOS PROCESOS PENALES EN CUBA
Authors: Matos Hidalgo Leaned 
Published: August 2019

Este artículo aborda los aspectos más generales acerca de la empresa estatal como tercero civil responsable en los procesos penales, identificando las principales limitaciones y las verdaderas posibilidades de intervención de este sujeto en sede penal, debido a que en el proceso de actualización del modelo económico cubano, este sujeto es fundamental en la gestión y desarrollo económico, y persisten varias brechas de impunidad civil por delitos de los agentes, funcionarios, directivos y trabajadores de estas entidades, que no coadyuvan a mejores mecanismos para la realización de su objeto social. En este sentido se hacen coincidir incorrectamente las responsabilidades civil y penal en el sujeto responsable penalmente, aspectos que se discuten en la investigación que se presenta, siendo de vital importancia la contextualización de los cuerpos legales a partir de la nueva constitución, que permitan que la víctima, en la mayoría de estos casos el Estado, obtenga una indemnización directa, segura y rápida por efectos del juzgamiento en un proceso penal.
Marketing Social para Prevenir el delito
Authors: Pérez Romero Luis Alfonso , Muñoz Cubillos Diana Paola 
Published: August 2019

Al observar los altos índices de criminalidad que se vienen desarrollando en el país de Colombia, surge la necesidad de una investigación que abra caminos para disminuir las cifras establecidas mes a mes del delito hurto, con el apoyo de la integración del derecho penal y del marketing social para la prevención del delito. La presente publicación es producto de la investigación realizada en 2014 en una de las comunas de la ciudad de Villavicencio, Colombia, con el objetivo general de aplicar el Marketing Social para la prevención del delito hurto cometido por jóvenes entre los 17 a 30 años de edad, centradas en las hipótesis del grado de punibilidad y tipo del delito versus variables propias del imputado como: edad, género, escolaridad, ocupación y hora en que cometen el delito. Se encontró el perfil del delincuente y su conducta, con clara ubicación geográfica que permitió desarrollar un modelo predictor para identificar al probable delincuente y desarrollar acciones del marketing social para disminuir la incidencia del delito hurto en esta comuna. Se identificaron las características del delito hurto a personas del mismo barrio, determinando su perfil, problemática y posibles soluciones; con el marco de referencia del marketing social, la administración, el derecho penal, las bases de datos proporcionadas por la Policía Metropolitana y con el apoyo de la comunidad, se generaron estrategias encaminadas a la prevención del delito
LA CORRUPCIÓN Y El JUICIO SÓCRATES
Authors: Coley José gabriel 
Published: August 2019

Una de las acusaciones de peso que llevó a Sócrates a la pena de muerte fue corromper la juventud ateniense. La pala corrupción proviene del latín corrumpere que significa sobornar, falsificar, dañar, romper, quebrar, despedazar, arrebatar, echar a perder, hacer claudicar, hacer trizas, inmoralidad, clientelismo, etc.
En aras de una definición, hoy día la corrupción es entendida como el uso de lo público para fines y lucros privados. La cosa pública (la república o república) se constituyó históricamente como una necesidad de protegernos los unos con los otros, contribuyendo todos para lograr el bien común.
Prevalence of Complications in Type 2 Diabetics in Dubai, UAE: A Cross-sectional Study
Authors: Al Sabbah Haleama , Alketbi Moaza , Dghaim Rania 
Published: August 2019

Background: Diabetes complications have been increasingly prevalent among type 2 diabetics during the past decades causing high rates of morbidity and mortality. Measures of the prevalence of diabetes complications will lead to preventive decisions and planning of health care. The main objective of this study was to assess the prevalence rates of complications in Type 2 diabetics in two Diabetes Centers in Dubai.
Methods: A cross-sectional descriptive analytical study conducted among type 2 diabetics attending diabetes centers in Dubai. Data was collected form secondary source using patients' records from two diabetes centers involved in the study. Random sampling technique was used to collect 150 patients proportionally allocated according to the total patients (4700 attending patients) available in the two diabetes centers. Data obtained was analyzed using SPSS v.22. Descriptive statistics were calculated (mean, standard deviation, and percentages). Chi-square test was used to compare frequencies between groups. The significance level was set at 0.05.
Results: The study showed that the most dominant prevalence type of complications were: Hyperlipidemia (84%), Neuropathy (34%), Dyslipidemia (32%), Retinopathy (28%), Lethargy (21.3%), and Nephropathy (16.7%). The associations made between three variables each separately (Date of First Visit, HbA1c, and Fasting Blood Glucose) with the prevalence type of complications, showed significant differences in some types: Dyslipidemia, Hyperlipidemia, Neuropathy, Retinopathy, and Joint & Bone pain.
Conclusions: There is a reasonable correlation between different variables and the prevalence of complications among the diabetic population, thus studies should always follow up on this issue in order to have clear associations to prevent complications from occurring in the first place.
ESTUDOS COMUNICACIONAIS NA AMÉRICA LATINA: alguns percursos
Authors: Echenique Raul Herrera , Baptista Renato Dias , Moraes Nelson Russo de , Porto Junior Francisco Gilson Rebouças 
Published: August 2019

Muitos pesquisadores se estabeleceram como autores de obras importantes sobre a comunicação como instrumentalidade inata humana dentro das perspectivas do estabelecimento de suas políticas e negociações e mesmo no ensaio dos primeiros tecidos sociais, que sob a forma de clãs e tribos envergavam-se sobre a busca de melhor instrumentalidade diante das demandas e riscos impostos pelo meio ambiente. A construção da sociedade contemporânea, contudo, salta das microrrelações humanas para grandes e complexas redes de interconexão, que sobre uma base tecnológica ascendente, une as pessoas mais distantes em diálogos e tecidos sociais que, embora eficazes, tornam – por vezes – tais relações mais superficiais e seus atores mais desengajados.
Pengaruh Naturalistic Intelligence dan New Environmental Paradigm terhadap Environmental Sensitivity
Authors: Ningtyas Lisa Dwi 
Published: August 2019

Globalization currently developing with very rapidly. The negative impact of the rapid development of globalization is environmental damage. One of the necessary to prevent damage to the environment that is environmental sensitivity on the self every students. Thatâ€™s the destination holding of this research, which is to find whether there is effect of naturalistic intelligence and new environmental paradigm toward studentsâ€™ environmental sensitivity. This research involving 91 students in Jakarta as a sample of random selected. There are 3 instruments has been developed to measure these variables. Each of the instruments has reliability .824, .583, and .579. Data has been analyzed by path analysis. The result of the research indicate that there is a significant effect between new environmental paradigm toward studentsâ€™ environmental sensitivity (.436). But, in this research it wasâ€™nt proven naturalistic intelligence contribute significantly toward studentsâ€™ new environmental paradigm or studentsâ€™ environmental sensitivity. so that, new environmental paradigm is not proven as a mediator variable that significantly mediates between naturalistic intelligence and studentsâ€™ environmental sensitivity. Therefore, in the increases studentsâ€™ environmental sensitivity , factor such as new environmental paradigm can be considered.
Hubungan Personality (Pro-Environmental Behavior) dengan Perilaku Pro-Lingkungan (Pro-Environmental Behavior) Siswa
Authors: Datau Rahmirini 
Published: August 2019

This study aims to discover the correlation between personality and pro-environmental behavior in students, personality is made up of five factors (openness, conscientiousness, extraversion, agreeableness, and neuroticism) that each have its own correlation towards the students moral environmental behavior. This study uses quantitative survey method and involves 89 data samples and was taken in SMAN 27 Jakarta. The data is collected through participant observation using questionnaire. Based on empirical data obtained as a result of this study, personality traits are an important factor that alters pro-environmental behavior in students, especially factors such as conscientiousness.
Spatial and temporal clusters of avian influenza A (H7N9) virus in humans across five epidemics in mainland China: an epidemiological study of laboratory-confirmed cases
Authors: Shan Xuzheng , Wang Yongqin , Song Ruihong , Wei Wen , Liao Hongxiu , Huang Huang , Xu Chunqiong , Chen Lvlin , Li Shiyun 
Published: August 2019

Abstract
Background: Avian influenza A (H7N9) virus was first reported in mainland China in 2013, and alarming in 2016-17 due to the surge in reported cases across a wide geographic area. Our study aimed to identify and explore the spatial and temporal variation across five epidemics to reinforce the epidemic prevention and control. Methods: We drew spatial and temporal information about all laboratory-confirmed human cases of A (H7N9) virus infection reported in mainland China covering 2013-17 from the open source. The autocorrelation analysis and intensity of cases were used to analyse the spatial cluster while circular distribution method was used to analyse the temporal cluster. Results: Across the five epidemics, a total of 1553 laboratory-confirmed human infection with A (H7N9) virus were reported in mainland China. The global Moran’s I index values of five epidemic were 0.610, 0.132, 0.308, 0.306, 0.336 respectively, all of which were statistically significant. Yangtze River Delta region and the Pearl River Delta region had the highest intensity, and range enlarged from the east of China to inner provinces and even the west of China across the five epidemics. The temporal clusters of the five epidemics were statistically significant, and the peak period was from the end of January to April. The peak periods of the first and fifth epidemic were later than the mean peak period. Conclusions: Spatial and temporal clusters of avian influenza A (H7N9) virus in humans indeed exist, moreover the regions existing clusters may enlarge across five epidemics. Yangtze River Delta region and the Pearl River Delta region have the spatial cluster and the peak period is from January to April. The government should facilitate the tangible improvement for the epidemic preparedness.
Seizure Impact on the School Attendance in Children with Epilepsy: Prospective Study in the Pediatrics Neurology Clinic at Tikur Anbessa Specialized Hospital,Addis Ababa, Ethiopia
Authors: Hassen Oumer , Beyene Ayalew moges 
Published: August 2019

Abstract
Abstract
Background:
Epilepsy is the most common chronic neurological disease seen in Pediatrics Neurology Units in developing countries and like other chronic disorders it has been found to negatively affect school attendance and academic performance influencing school life of children. An educational underachievement can also be due to comorbid learning and behavioral problems in these children. The impact of epilepsy on school attendance may also contribute to the academic difficulties of children with epilepsy. The purpose of this study is to assess school absenteeism and determine which factors influence school absenteeism in school aged children and adolescents with epilepsy.
Methods:
A hospital based prospective study was conducted among school aged children and adolescents with epilepsy between the ages of 7-18 years attending at the Paediatric Neurology Clinic and their primary caretakers. A sample of 183 children and adolescents were included in the study. The participants (children and their parents/caregivers) gave information concerning the socio-demographic data, primary caregiver’s information like educational status, information concerning child’s seizure and epilepsy status disclosures to teachers and peer. And medical cards were thoroughly reviewed. Descriptive statistics and bi-variate logistic regression analysis was done to assess determinants of school absenteeism.
Results:
The prevalence of school absenteeism among children aged 7-18years at PNC follow up was 69.4%.Among other factors female sex with AOR 2.19(95% CI 1.03-4.84), having symptomatic seizure AOR 2.51(95% CI 1.09-5.86), having seizure at school and having longer duration of seizure were statistically significant association with school absenteeism.
Conclusion:
This study demonstrated the school absenteeism is very common among children aged 7-18 years at PNC follow up (69.4%) and that seizure has a significant impact on children’s school attendance.
Keywords: Epilepsy; School; Childhood; Absenteeism; Ethiopia
Trial registration: N/A
Physiological significance of ClpP in Enterococcus faecalis and its regulating proteins were identified by Tandem Mass Tag Mass Spectrometry
Authors: Zheng Jinxin , Wu Yang , Lin Zhiwei , Wang Guangfu , Jiang Sibo , Sun Xiang , Tu Haopeng , Yu Zhi-jian , Qu Di 
Published: August 2019

Abstract
Background

ClpP is important for bacterial growth and plays an indispensable role in cellular protein quality control systems by refolding or degrading damaged proteins, but the physiological significance of ClpP in Enterococcus faecalis is still obscure. Thus a clpP deletion mutant (△clpP) was constructed in E. faecalis OG1RF strain to elucidate a more comprehensive picture of the effect of ClpP on E. faecalis. The global abundance of proteins was determined by a mass spectrometer with Tandem Mass Tags labeling.

Results

The ΔclpP mutant strain showed impaired growth at 20°C or 45°C, at 5% NaCl or 2 mM H2O2. The surviving bacteria of the ΔclpP mutant strain reduced after exposure to the high concentration (50 x MIC) of linezolid or minocycline for 96 h. The ΔclpP mutant strain also demonstrated decreased biofilm formation but increased virulence in a Galleria mellonella model. The mass spectrometry proteomics data indicated that the abundances of 135 proteins changed (111 proteins increased, 24 proteins decreased) in the ΔclpP mutant strain. Among those differential abundance proteins, the abundances of stress response or virulence relating proteins: FsrA response regulator, gelatinase GelE, regulatory protein Spx (spxA), heat-inducible transcription repressor HrcA, transcriptional regulator CtsR, ATPase/chaperone ClpC, acetyl esterase/lipase, and chaperonin GroEL increased in the ΔclpP mutant strain; however, the abundances of ribosomal protein L4/L1 family protein (rplD), ribosomal protein L7/L12 (rplL2), 50S ribosomal protein L13 (rplM), L18 (rplR), L20 (rplT), 30S ribosomal protein S14 (rpsN2) and S18 (rpsR) all reduced. The abundances of biofilm formation related adapter protein MecA increased, while the abundances of dihydroorotase (pyrC), orotate phosphoribosyltransferase (pyrE) and orotidine-5'-phosphate decarboxylase (pyrF) all decreased in the ΔclpP mutant strain.

Conclusion

The present study demonstrates that ClpP participates in stress tolerance, biofilm formation, antimicrobials tolerance, and virulence of E. faecalis.
An Anaplastic Lymphoma Kinase Pathway Signature is associated with Cell De-differentiation, Neoadjuvant Response and Recurrence Risk in Breast Cancer
Authors: Wu Yong , Liu Dingxie 
Published: August 2019

Abstract
The role of ALK signaling in the pathogenesis of breast cancer (BC) is not clear. Previously we generated a gene signature for ALK pathway based on the difference of gene expression profiles between tumor cells with activated and inactive ALK pathway. Here, this signature was used to compute ALK pathway activity in BC samples from 42 microarray datasets, and the associations between ALK pathway score and the clinical outcome were examined by logistic regression and survival analysis. Our results indicated that high ALK pathway activity was a significant risk factor for the presence of higher-grade breast cancer with loss of ER and PR expression in the 42 datasets (n= 6381). ALK pathway activity was also positively associated with pathological complete response (pCR) in 15 datasets annotated with patient’s neoadjuvant response information (n= 2093, overall OR 1.67, p=2.00E-12), and with recurrence risk in 30 datasets annotated with patient’s survival information (n= 4678, overall HR 1.21, p=3.31E-08). The associations of ALK pathway activity with pCR and recurrence were more significant in HER2 negative and grade 1&2 tumors than in HER2 positive and grade 3 tumors. Notably, the association between ALK and tumor recurrence was statistically significant in patient with age>50 but not ≤50 years old, in patient with positive but not negative lymph node and in patients with residual disease but not pCR following neoadjuvant chemotherapy. These data indicate that ALK may be involved in BC tumorigenesis and ALK pathway signature represents a novel biomarker for BC clinical management.