bluuebunny/crossref_metadata_2025_split huggingface dataset:
Structures and electronic properties of domain walls in BiFeO3 thin films
Authors: Huyan Huaixun , Li Linze , Addiego Christopher , Gao Wenpei , Pan Xiaoqing 
Published: July 2019

Abstract
Domain walls (DWs) in ferroelectrics are atomically sharp and can be created, erased, and reconfigured within the same physical volume of ferroelectric matrix by external electric fields. They possess a myriad of novel properties and functionalities that are absent in the bulk of the domains, and thus could become an essential element in next-generation nanodevices based on ferroelectrics. The knowledge about the structure and properties of ferroelectric DWs not only advances the fundamental understanding of ferroelectrics, but also provides guidance for the design of ferroelectric-based devices. In this article, we provide a review of structures and properties of DWs in one of the most widely studied ferroelectric systems, BiFeO3 thin films. We correlate their conductivity and photovoltaic properties to the atomic-scale structure and dynamic behaviors of DWs.
Definitions, regulations, and new frontiers for dietary fiber and whole grains
Authors: Korczak Renee , Slavin Joanne L 
Published: July 2019

AbstractThe aim of this article is to review the definitions and regulations for dietary fiber and whole grains worldwide and to discuss barriers to meeting recommended intake levels. Plant foods, such as whole grains, that are rich in dietary fiber are universally recommended in dietary guidance. Foods rich in dietary fiber are recommended for all, but dietary recommendations for whole grains and dietary fiber depend on definitions and regulations. Official recommendations for dietary fiber in the United States and Canada are denoted by dietary reference intakes (DRIs), which are developed by the Institute of Medicine. An adequate intake (AI) for dietary fiber was based on prospective cohort studies of dietary fiber intake and cardiovascular disease risk that found 14 grams of dietary fiber per 1000 kilocalories protected against cardiovascular disease (CVD). This value was used to set AIs for dietary fiber across the life cycle based on recommended calorie intakes. Actual intakes of dietary fiber are generally about half of the recommended levels. Recommendations for whole grain intake are equally challenging, as definitions for whole grain foods are needed to set recommendations. The 2005 Dietary Guidelines for Americans recommended that half of all grain servings be whole grains, but usual intakes are generally less than 1 serving per day, rather than the recommended 3 servings per day. Scientific support for whole grain recommendations is based on the same prospective cohort studies and links to CVD protection used to inform dietary fiber guidance. Thus, dietary fiber is a recommended nutrient and whole grains are a recommended dietary pattern in dietary guidance in North America and around the world. Challenges for attaining recommended intakes of dietary fiber and whole grains include low-carbohydrate diets, low-gluten diets, and public health recommendations to avoid processed foods.
Heats of combustion of the main carbohydrates contained in plant-source foods
Authors: Sánchez-Peña María Judith , Martínez-Navarro Ana Guadalupe , Márquez-Sandoval Fabiola , Gutiérrez-Pulido Humberto , Pacheco-Moisés Fermín Paul , González-Ortiz Luis Javier 
Published: July 2019

Abstract
In a previous review, the experiments of American chemist W.O. Atwater were critically examined, with the findings demonstrating certain weaknesses that could compromise the validity of the values currently used for metabolizable energy. An examination of published works on the heat of combustion of carbohydrates reveals 2 types of weaknesses: the inaccuracy and imprecision of the calorimetric data used, and the averaging procedure employed to estimate such representative values. The present review focuses on the first type of weakness, namely the inaccuracy and imprecision of the calorimetric data used in previous studies. An exhaustive bibliographic search yielded almost 100 heat of combustion values for some of the 6 main carbohydrates contained in plant-source foods (glucose, fructose, sucrose, maltose, starch, and cellulose). These heats of combustion were subjected to rigorous statistical analysis to propose the following for each carbohydrate: (1) an interval (termed a bibliographic interval) that very likely includes the actual heat of combustion value and (2) a “representative value” (calculated to produce the minimum level of inaccuracy). In addition, an estimation of the maximum level of inaccuracy that could be expected when using such a representative value is reported.
Patient-centred care in an occupational medicine clinic
Authors: Lari S , Thompson A M S , Spilchuk V , Afanasyeva M , Holness D L 
Published: July 2019

Abstract

Background
Patient-centred care (PCC) has been associated with improved patient satisfaction outcomes in a variety of clinical settings. There is a paucity of research addressing the concept of PCC in an occupational medicine context.

Aims
To assess patient perception and compare physician and patient perceptions of patient centredness of the care at a specialty occupational medicine clinic.

Methods
An observational study design using the Patient Perception of Patient Centeredness Questionnaire (PPPC) at an ambulatory tertiary care occupational health clinic. Results were analysed using a standardized coding system. Summary scores were compared to results reported in a primary care setting. Patient and physician scores were compared to detect physician–patient differences in perceived patient centredness of care.

Results
Of 47 eligible patients 37 consented to participate and seven were excluded due to incomplete data. Summary scores of patient perceptions of patient centredness were similar but somewhat better than scores reported in a primary care setting. Perceived patient centredness of care was high and there was minimal discordance between patient and physician scores.

Conclusions
This study demonstrated that PCC can be measured in an occupational health setting. In an ambulatory tertiary care occupational health clinic there was a high degree of patient centredness of care which may be explained by a variety of factors. Future research should consider whether similar findings exist in other occupational medicine practice settings.
Select Committees and Brexit: Parliamentary Influence in a Divisive Policy Area
Authors: Lynch Philip , Whitaker Richard 
Published: July 2019

Abstract
In this first comprehensive study of House of Commons departmental select committees and Brexit, we analyse the incidence of divisions (i.e. formal votes) on Brexit-related issues in select committees, showing that unanimity remains the norm with the exception of the Exiting the EU Committee, which is the most divided select committee of recent times. We add to the literature on select committee influence by adapting Russell and Benton’s (2011) methodology to examine government responses to committee recommendations on Brexit. We show that most have been partially accepted but that the level of policy change, rather than divisions on recommendations, is the main factor explaining variation, with greater success for recommendations suggesting a lower degree of change. Committees have also had indirect influence, shaping the agenda and bringing information into the public domain.
Q-type asteroids: Possibility of non-fresh weathered surfaces
Authors: Hasegawa Sunao , Hiroi Takahiro , Ohtsuka Katsuhito , Ishiguro Masateru , Kuroda Daisuke , Ito Takashi , Sasaki Sho 
Published: July 2019

Abstract
Itokawa particles, which are samples recovered from the S-complex asteroid 25143 Itokawa by the Hayabusa spacecraft, demonstrate that S-complex asteroids are parent bodies of ordinary chondrite meteorites. Furthermore, they clarify that the space-weathering age of the Itokawa surface is of the order of several thousand years. Traditionally, Q-type asteroids have been considered fresh-surfaced. However, as the space-weathering timescale is approximately three orders of magnitude lesser than the conventionally considered age, the previously proposed formation mechanisms of Q-type asteroids cannot sufficiently explain the surface refreshening. In this study, we propose a new hypothesis on the surface state of Q-type asteroids: Q-type asteroids have a non-fresh weathered surface with a paucity of fine particles. For verifying this hypothesis, laboratory experiments on the space weathering of ordinary chondrites are performed. Based on the results of these experiments, we found that large (more than $100\, \mu \mathrm{m}$) ordinary chondritic particles with space weathering exhibit spectra consistent with Q-type asteroids.
Multifactorial and Species-Specific Feedback Regulation of the RNA Surveillance Pathway Nonsense-Mediated Decay in Plants
Authors: Kesarwani Anil K , Lee Hsin-Chieh , Ricca Patrizia G , Sullivan Gabriele , Faiss Natalie , Wagner Gabriele , Wunderling Anna , Wachter Andreas 
Published: July 2019

Abstract
Nonsense-mediated decay (NMD) is an RNA surveillance mechanism that detects aberrant transcript features and triggers degradation of erroneous as well as physiological RNAs. Originally considered to be constitutive, NMD is now recognized to be tightly controlled in response to inherent signals and diverse stresses. To gain a better understanding of NMD regulation and its functional implications, we systematically examined feedback control of the central NMD components in two dicot and one monocot species. On the basis of the analysis of transcript features, turnover rates and steady-state levels, up-frameshift (UPF) 1, UPF3 and suppressor of morphological defects on genitalia (SMG) 7, but not UPF2, are under feedback control in both dicots. In the monocot investigated in this study, only SMG7 was slightly induced upon NMD inhibition. The detection of the endogenous NMD factor proteins in Arabidopsis thaliana substantiated a negative correlation between NMD activity and SMG7 amounts. Furthermore, evidence was provided that SMG7 is required for the dephosphorylation of UPF1. Our comprehensive and comparative study of NMD feedback control in plants reveals complex and species-specific attenuation of this RNA surveillance pathway, with critical implications for the numerous functions of NMD in physiology and stress responses.
Unravelling GSNOR-Mediated S-Nitrosylation and Multiple Developmental Programs in Tomato Plants
Authors: Gong Biao , Yan Yanyan , Zhang Lili , Cheng Fei , Liu Zhen , Shi Qinghua 
Published: July 2019

Abstract
Nitric oxide (NO) impacts multiple developmental events and stress responses in plants. S-nitrosylation, regulated by S-nitrosoglutathione reductase (GSNOR), is considered as an important route for NO bioactivity. However, genetic evidence for GSNOR-mediated plant development and S-nitrosylation remains elusive in crop species. Genetic and site-specific nitrosoproteomic approach was used to obtain GSNOR-mediated phenotype and S-nitrosylated network. Knockdown of GSNOR increased the endogenous NO level and S-nitrosylation, resulting in higher germination rate, inhibition of root and hypocotyl growth, decreased photosynthesis, reduced plant growth, altered plant architecture, dysplastic pollen grains, and low fructification rate and fruit yield. For nitrosoproteomic analysis, 395 endogenously S-nitrosylated proteins with 554 S-nitrosylation sites were identified within a wide range of biological processes, especially for energy metabolism. Physiological and exogenous energy-support testing were consistent with the omic result, suggesting that GSNOR-mediated S-nitrosylation of energy metabolism plays key roles in impacting plant growth and development. Taken together, GSNOR is actively involved in the regulation of multiple developmental processes related to agronomically important traits. In addition, our results provide valuable resources and new clues for the study of S-nitrosylation-regulated metabolism in plants.
Competing Endogenous RNA Networks Underlying Anatomical and Physiological Characteristics of Poplar Wood in Acclimation to Low Nitrogen Availability
Authors: Lu Yan , Deng Shurong , Li Zhuorong , Wu Jiangting , Liu Qifeng , Liu Wenzhe , Yu Wen-Jian , Zhang Yuhong , Shi Wenguang , Zhou Jing , Li Hong , Polle Andrea , Luo Zhi-Bin 
Published: July 2019

Abstract
Although poplar plantations are often established on nitrogen (N)-poor soil, the physiological and molecular mechanisms underlying wood properties of poplars in acclimation to low N availability remain largely unknown. To investigate wood properties of poplars in acclimation to low N, Populus ï¿½ canescens saplings were exposed to either 50 (low N) or 500 (normal N) ï¿½M NH4NO3 for 2 months. Low N resulted in decreased xylem width and cell layers of the xylem (the number of cells counted along the ray parenchyma on the stem cross section), narrower lumina of vessels and fibers, greater thickness of double fiber walls (the walls between two adjacent fiber cells), more hemicellulose and lignin deposition, and reduced cellulose accumulation in poplar wood. Consistently, concentrations of gibberellins involved in cell size determination and the abundance of various metabolites including amino acids, carbohydrates and precursors for cell wall biosynthesis were decreased in low N-supplied wood. In line with these anatomical and physiological changes, a number of mRNAs, long noncoding RNAs (lncRNAs) and microRNAs (miRNAs) were significantly differentially expressed. Competing endogenous RNA regulatory networks were identified in the wood of low N-treated poplars. Overall, these results indicate that miRNAs–lncRNAs–mRNAs networks are involved in regulating wood properties and physiological processes of poplars in acclimation to low N availability.
Pain, Anxiety, and Depression in the First Two Years Following Transport-Related Major Trauma: A Population-Based, Prospective Registry Cohort Study
Authors: Giummarra Melita J , Simpson Pamela , Gabbe Belinda J 
Published: July 2019

AbstractObjectivesThis study aimed to characterize the population prevalence of pain and mental health problems postinjury and to identify risk factors that could improve service delivery to optimize recovery of at-risk patients.MethodsThis population-based registry cohort study included 5,350 adult survivors of transport-related major trauma injuries from the Victorian State Trauma Registry. Outcome profiles were generated separately for pain and mental health outcomes using the “pain or discomfort” and “anxiety or depression” items of the EuroQol Five Dimensions Three-Level questionnaire at six, 12, and 24 months postinjury. Profiles were “resilient” (no problems at every follow-up), “recovered” (problems at six- and/or 12-month follow-up that later resolved), “worsening” (problems at 12 and/or 24 months after no problems at six and/or 12 months), and “persistent” (problems at every follow-up).ResultsMost participants had persistent (pain/discomfort, N = 2,171, 39.7%; anxiety/depression, N = 1,428, 26.2%) and resilient profiles (pain/discomfort, N = 1,220, 22.3%; anxiety/depression, N = 2,055, 37.7%), followed by recovered (pain/discomfort, N = 1,116, 20.4%; anxiety/depression, N = 1,025, 18.8%) and worsening profiles (pain/discomfort, N = 956, 17.5%; anxiety/depression, N = 948, 17.4%). Adjusted multinomial logistic regressions showed increased risk of problems (persistent, worsening, or resolved) vs no problems (resilient) in relation to female sex, middle age, neighborhood disadvantage, pre-injury unemployment, pre-injury disability, and spinal cord injury. People living in rural areas, motorcyclists, pedal cyclists, and people with head, chest, and abdominal injuries had lower risk of problems.DiscussionTargeted interventions delivered to people with the risk factors identified may help to attenuate the severity and impact of pain and mental health problems after transport injury.
Effects of Rescheduling Hydrocodone on Opioid Prescribing in Ohio
Authors: Liu Yingna , Baker Olesya , Schuur Jeremiah D , Weiner Scott G 
Published: July 2019

AbstractBackgroundWe quantified opioid prescribing after the 2014 rescheduling of hydrocodone from schedule III to II in the United States using a state-wide prescription database and studied trends three years before and after the policy change, focusing on certain specialties.MethodsWe used Ohio’s state prescription drug monitoring program database, which includes all filled schedule II and III prescriptions regardless of payer or pharmacy, to conduct an interrupted time series analysis of the nine most prescribed opioids: hydrocodone, oxycodone, tramadol, codeine, and others. We analyzed hydrocodone prescribing trends for the physician specialties of internal medicine, anesthesiology, and emergency medicine. We evaluated trends 37 months before and after the rescheduling change.ResultsRescheduling was associated with a hydrocodone level change of –26,358 (95% confidence interval [CI] = –36,700 to –16,016) prescriptions (–5.8%) and an additional decrease in prescriptions of –1,568 (95% CI = –2,296 to –839) per month (–0.8%). Codeine prescribing temporarily increased, at a level change of 6,304 (95% CI = 3,003 to 9,606) prescriptions (18.5%), indicating a substitution effect. Hydrocodone prescriptions by specialty were associated with a level change of –805 (95% CI = –1,280 to –330) prescriptions (–8.5%) for anesthesiologists and a level change of –14,619 (95% CI = –23,710 to –5,528) prescriptions (–10.2%) for internists. There was no effect on prescriptions by emergency physicians.ConclusionsThe 2014 federal rescheduling of hydrocodone was associated with declines in hydrocodone prescriptions in Ohio beyond what had already been occurring, and hydrocodone may have been briefly substituted with codeine. These results indicate that rescheduling did have a lasting effect but affected prescribing specialties variably.
Is the Brief-BESTest Brief Enough? Suggested Modifications Based on Structural Validity and Internal Consistency
Authors: Godi Marco , Giardini Marica , Arcolin Ilaria , Ferrante Simona , Nardone Antonio , Corna Stefano , Colombo Roberto 
Published: July 2019

Abstract

Background
The Brief Balance Evaluation Systems Test (Brief-BESTest) could be a useful tool for balance assessment. Although some psychometric characteristics have been examined, others still need to be clarified.

Objective
The objective was to assess the structural validity, convergent validity, discriminant validity, and internal consistency of the Brief-BESTest in neurological patients.

Design
This was a cross-sectional study.

Methods
Data were from 416 patients with neurological disease and related balance disorders. Patients were assessed with the 5-levels Activities-Specific Balance Confidence Scale (ABC 5-levels), Brief-BESTest, and some simple balance tests (ie, 1-leg stance, Timed “Up & Go” test, functional reach, and a fall history questionnaire). Three Brief-BESTest models were examined through confirmatory factor analysis, and the following indexes were calculated: Comparative Fit Index, Tucker-Lewis Index, and root-mean-square error of approximation. Convergent validity was assessed by calculating the correlation between Brief-BESTest and ABC 5-levels total scores. Receiver operating characteristics assessed the ability of each model to differentiate between people with falls and those without falls. Internal consistency was measured with Cronbach α and coefficient ω.

Results
Confirmatory factor analysis showed model 3 (Comparative Fit Index = 0.97; Tucker-Lewis Index = 0.95; root-mean-square error of approximation = 0.05), with item 1 removed and error covariance between items 3 and 4 and between items 5 and 6, to have a significantly better structure than models 1 and 2. The correlation between Brief-BESTest and ABC 5-levels was 0.61 (Spearman ρ) for all 3 models. The area under the curve of the receiver operating characteristics showed an acceptable accuracy (0.72) in distinguishing patients with a history of falls from those without a history of falls (95% confidence interval = 0.66–0.78) for all models and was superior to the areas under the curve of other simple balance tests (1-leg stance, Timed “Up & Go” test, functional reach). Cronbach α was good for Brief-BESTest models 1 (0.92) and 3 (0.92), but ω was greater than 0.80 only for model 3.

Limitations
The sample was heterogeneous.

Conclusions
The Brief-BESTest, after some changes, shows good validity and internal consistency in patients affected by different balance disorders.
Ambiguity, Volatility, and Credit Risk
Authors: Augustin Patrick , Izhakian Yehuda 
Published: July 2019

Abstract
We explore the implications of ambiguity for the pricing of credit default swaps (CDSs). A model of heterogeneous investors with independent preferences for ambiguity and risk shows that, because CDS contracts are assets in zero net supply, the net credit risk exposure of the marginal investor determines the sign of the impact of ambiguity on CDS spreads. We find that ambiguity has an economically significant negative impact on CDS spreads, on average, suggesting that the marginal investor is a net buyer of credit protection. A 1-standard-deviation increase in ambiguity is estimated to decrease CDS spreads by approximately 6%. (JEL C65, D81, D83, G13, G22)
Authors have furnished an Internet Appendix, which is available on the Oxford University Press Web site next to the link to the final published paper online.
The association between lymphopenia and serious infection risk in rheumatoid arthritis
Authors: Subesinghe Sujith , Kleymann Alexander , Rutherford Andrew Ian , Bechman Katie , Norton Sam , Benjamin Galloway James 
Published: July 2019

Abstract

Objectives
To investigate the relationship between occurrence of serious infection (SI) and lymphocyte counts in patients with RA using data from a single centre.

Methods
We used routinely captured data from a single tertiary rheumatology centre to explore the relationship between lymphopenia and SI risk. Adult RA patients were included over a 5-year follow-up period. Admissions due to confirmed SI were considered. SI rate with 95% confidence intervals was calculated. The association between SI with baseline lymphocyte counts, time-averaged lymphocyte counts throughout all follow-up, and a nadir lymphocyte count was assessed using Cox proportional hazards regression. The relationship between lymphopenia over time and SI was analysed using a mixed-effect model of lymphocyte counts prior to SI.

Results
This analysis included 1095 patients with 205 SIs during 2016 person-years of follow-up. The SI rate was 4.61/100 patient-years (95% CI: 3.76, 5.65). Compared with patients with nadir lymphocyte counts &gt;1.5 × 109 cells/l, nadir lymphopenia &lt;1 × 109 cells/l was significantly associated with higher SI risk (HR 3.28; 95% CI: 1.59, 6.76), increasing to HR 8.08 (95% CI: 3.74, 17.44) in patients with lymphopenia &lt;0.5 × 109 cells/l. Lymphocyte counts were observed to be reduced in the 30-day period prior to SI.

Conclusion
Lymphocyte counts below &lt;1.0 × 109 cells/l were associated with higher SI risk in RA patients; the strongest association between lymphopenia and SI was observed when lymphocyte counts were below &lt;0.5 × 109 cells/l. Lymphopenia may be used as a measure to stratify patients at risk of SI.