bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pair-wise Comparison Analysis for Multiple Pool-seq: an efficient method identified anthocyanin biosynthesis genes in rice pericarp
Authors: Yang Xinghai , Xia Xiuzhong , Zhang Zongqiong , Nong Baoxuan , Zeng Yu , Wu Yanyan , Xiong Faqian , Zhang Yuexiong , Liang Haifu , Pan Yinghua , Dai Gaoxing , Deng Guofu , Li Danting 
Published: February 2019

AbstractThe complex traits are derived from multiple genes and exhibit a large variety of phenotypes. High-throughput sequencing technologies have become the new strategies for mapping the important traits of crops. However, these methods have their own disadvantages and limitations. Here we introduced Pair-wise Comparison Analysis for Multiple Pool-seq (PCAMP) for mapping the candidate genomic regions involved in anthocyanin biosynthesis in rice pericarp. In this protocol, the second filial generation (F2) populations obtained by crossing two parents with different target traits were divided into n (n>=3) subpopulations according to their phenotypes. Thirty phenotypically identical individuals were selected from each subpopulation and DNA samples were extracted to form a pool for sequencing. Finally, we compared the SNP-index between every two Pool-seqs to map the candidate genomic regions. We applied PCAMP to analyse F2populations and successfully identified five known genes and five new candidate genomic regions for anthocyanin biosynthesis in rice pericarp. These results demonstrate that PCAMP is an efficient new method for dissecting the complex traits of crops.
Pharmacogenomics, biomarker network and allele frequencies in colorectal cancer
Authors: López-Cortés Andrés , Paz-y-Miño César , Guerrero Santiago , Jaramillo-Koupermann Gabriela , Intriago-Baldeón Dámaris P. , García-Cárdenas Jennyfer M. , Guevara-Ramírez Patricia , Armendáriz-Castillo Isaac , Leone Paola E. , Quiñones Luis Abel , Cayún Juan Pablo , Soria Néstor W. 
Published: February 2019

ABSTRACTColorectal cancer (CRC) is one of the leading causes of cancer death worldwide. Over the last decades, several studies have shown that tumor-related genomic alterations predict tumor prognosis, drug response and toxicity. These observations have led to the development of a number of precision therapies based on individual genomic profiles. As part of these approaches, pharmacogenomics analyses genomic alterations that may predict an efficient therapeutic response. Studying these mutations as biomarkers for predicting drug response is of a great interest to improve precision medicine. Here we conduct a comprehensive review of the main pharmacogenomics biomarkers and genomic alterations affecting enzyme activity, transporter capacity, channels and receptors, and therefore the new advances in CRC precision medicine to select the best therapeutic strategy in populations worldwide, with a focus on Latin America.
Divisively normalized integration of multisensory error information develops motor memories specific to vision and proprioception
Authors: Hayashi Takuji , Kato Yutaro , Nozaki Daichi 
Published: February 2019

ABSTRACTBoth visual and proprioceptive information contribute to accurate limb movement, but the mechanism of integration of these different modality signals for movement control and learning remains controversial. Here, we aimed to elucidate the mechanism of integration by examining motor adaptation when various combinations of visual and proprioceptive perturbations were applied during reaching movements. We found that the movement corrections by adaptation were explained by a mechanism known as a divisive normalization, which was previously reported to be the mechanism underlying the integration of multisensory signals in neurons. Furthermore, we found evidence that the motor memory for each sensory modality was formed separately and the outputs from these memories were integrated. These results provide a novel view of the utilization of different sensory modality signals in motor control and adaptation.
xiView: A common platform for the downstream analysis of Crosslinking Mass Spectrometry data
Authors: Graham Martin , Combe Colin , Kolbowski Lars , Rappsilber Juri 
Published: February 2019

AbstractxiView provides a common platform for the downstream analysis and visualisation of Crosslinking Mass Spectrometry data. It is independent of the search software used and its input is compliant with the relevant mass spectrometry data standards. It uses established visualisation techniques, notably Multiple Coordinated Views, to help the user explore the data and is designed to facilitate comparisons between different datasets.
Integrated approaches to identifying cryptic bat species in areas of high endemism: the case ofRhinolophus andamanensisin the Andaman Islands
Authors: Srinivasulu Chelmala , Srinivasulu Aditya , Srinivasulu Bhargavi , Jones Gareth 
Published: February 2019

AbstractThe diversity of bats worldwide includes large numbers of cryptic species, partly because divergence in acoustic traits such as echolocation calls are under stronger selection than differences in visual appearance in these nocturnal mammals. Island faunas often contain disproportionate numbers of endemic species, and hence we might expect cryptic, endemic species to be discovered relatively frequently in bats inhabiting islands. Species are best defined when multiple lines of evidence supports their diagnosis. Here we use morphometric, acoustic, and molecular phylogenetic data to show that a horseshoe bat in the Andaman Islands is distinct in all three aspects, supporting its description as a newly described endemic species. We recommend investigation into possible new and endemic bat species on islands by using integrated approaches that provide independent lines of evidence for taxonomic distinctiveness. We provide a formal description of the new species –Rhinolophus andamanensisDobson, 1872.
Quantitative investigation of factors relevant to the T cell spot test for tuberculosis infection in active tuberculosis
Authors: Li Kui , Yang Caiyong , Jiang Zicheng , Liu Shengxi , Liu Jun , Fan Chuanqi , Li Tao , Dong Xuemin 
Published: February 2019

AbstractBackgroundPrevious qualitative studies suggested that the false negative rate of T cell spot test for tuberculosis infection (T-SPOT.TB) is associated with many risk factors in tuberculosis patients; However, more precise quantitative studies are not well known.ObjectiveTo investigate the factors affecting quantified T-SPOT.TB in patients with active tuberculosis.MethodsWe retrospectively analyzed the data of 360 patients who met the inclusion criteria. Using the levels of early secreted antigenic target 6 kDa (ESAT-6) and culture filtrate protein 10 kDa (CFP-10) as dependent variables, variables with statistical significance in the univariate analysis were subjected to optimal scaling regression analysis.ResultsThe results showed that the ESAT-6 regression model had statistical significance (P-trend < 0.001) and that previously treated cases, CD4+ and platelet count were its independent risk factors (all P-trend < 0.05); their importance levels were 0.095, 0.596 and 0.100, respectively, with a total of 0.791. The CFP-10 regression model also had statistical significance (P-trend < 0.001); platelet distribution width and alpha-2 globulin were its independent risk factors (all P-trend < 0.05), their importance levels were 0.287 and 0.247, respectively, with a total of 0.534. The quantification graph showed that quantified T-SPOT.TB levels had a linear correlation with risk factors.ConclusionThe test results of T-SPOT.TB should be given more precise explanations, especially in patients with low levels of CD4+, platelet, alpha-2 globulin and high platelet distribution width.
RBF-based mesh morphing approach to perform icing simulations in the aviation sector
Authors: Groth Corrado , Costa Emiliano , Biancolini Marco Evangelos 
Published: February 2019

Purpose
Numerical simulation of icing has become a standard. Once the iced shape is known, however, the analyst needs to update the computational fluid dynamics (CFD) grid. This paper aims to propose a method to update the numerical mesh with ice profiles.

Design/methodology/approach
The present paper concerns a novel and fast radial basis functions (RBF) mesh morphing technique to efficiently and accurately perform ice accretion simulations on industrial models in the aviation sector. This method can be linked to CFD analyses to dynamically reproduce the ice growth.

Findings
To verify the consistency of the proposed approach, one of the most challenging ice profile selected in the LEWICE manual was replicated and simulated through CFD. To showcase the effectiveness of this technique, predefined ice profiles were automatically applied on two-dimensional (2D) and three-dimensional (3D) cases using both commercial and open-source CFD solvers.

Practical implications
If ice accreted shapes are available, the meshless characteristic of the proposed approach enables its coupling with the CFD solvers currently supported by the RBF4AERO platform including OpenFOAM, SU2 and ANSYS Fluent. The advantages provided by the use of RBF are the high performance and reliability, due to the fast application of mesh smoothing and the accuracy in controlling surface mesh nodes.

Originality/value
As far as authors’ knowledge is concerned, this is the first time in scientific literature that RBF are proposed to handle icing simulations. Due to the meshless characteristic of the RBF mesh morphing, the proposed approach is cross solver and can be used for both 2D and 3D geometries.
Benchmarking energy use of iron and steel industry: a data envelopment analysis
Authors: Haider Salman , Mishra Prajna Paramita 
Published: February 2019

PurposeThe purpose of this paper is to benchmark the energy use of Indian iron and steel industry. For this purpose, the authors have estimated a production frontier to know the best performing states. Further, the energy-saving targets are estimated to lie below the benchmark level for those states. Panel data for this purpose are extracted from the Annual Survey of Industry (an official database from the government of India) for 19 major steel-producing states over the period from 2004–2005 to 2013–2014.Design/methodology/approachThe authors employed a radial and non-radial (slack-based measure) variant of the data envelopment analysis (DEA) to estimate the production frontier. Particularly, slack-based measures (SBMs) developed by Tone (2001) are used to get a more comprehensive measure of energy efficiency along with technical efficiency. Variable returns to scale technology is specified to accommodate market imperfection and heterogeneity across states. Four inputs (capital, labour, energy and material) and a single output are conceptualised for the production process to accommodate input substitution. The relative position of each state in terms of the level of energy efficiency is then identified.FindingsThe authors started by examining energy-output ratio. The average level of energy intensity shows declining trends over the period of time. States like Bihar, Jharkhand, Gujarat and Uttarakhand remain stagnant in the energy intensity level. SBM of energy efficiency shows an overall average energy saving potential of 8 per cent without reducing average output level. Considerable heterogeneity exists among states in terms of the energy efficiency scores. Further, the authors calculated scale efficiency (SE) which shows the overall average level of SE is 0.91; hence, the scale of operation is not optimal and needs to adjusted to enhance energy efficiency.Originality/valueThe authors demonstrate the empirical application of DEA with SBM to energy use performance. This is the first study that benchmarks Indian states in terms of the consumption of energy input to produce iron and steel by applying DEA.
Examining the mediating effect of trust and psychological well-being on transformational leadership and organizational commitment
Authors: Jain Priyanka , Duggal Taranjeet , Ansari Amirul Hasan 
Published: February 2019

Purpose
The purpose of this paper is to extend the under-researched work on employees’ organizational commitment by examining transformational leadership (TL) adopted by the leader and the level of trust subordinates have in such a leader.

Design/methodology/approach
Data were collected using convenience sampling and self-administered survey methods from professionals employed in Indian public sector banks (n=236).

Findings
Findings reveal that the subordinates’ level of trust and psychological well-being partially mediates the relationship between TL and employees’ organizational commitment.

Practical implications
TL shares a positive relationship with organizational commitment through trust and psychological well-being.

Originality/value
Even though previous studies on organizational commitment have produced a significant piece of work, this study is among the first to propose and analyze a comprehensive and theoretically grounded structure of TL, organizational commitment, level of trust and employees’ psychological well-being.
Implementation model for cellular manufacturing system using AHP and ANP approach
Authors: Sharma Vikrant , Gidwani B.D. , Sharma Vikram , Meena M.L. 
Published: February 2019

PurposeThe purpose of this paper is to visualize the prioritization among essential factors of cellular manufacturing system (CMS) implementation using the analytic hierarchy process (AHP) and analytic network process (ANP) methods.Design/methodology/approachBased on literature review, 4 enabler dimensions and 17 CM factors were identified which were validated by experts from academia and industry. Then, AHP and ANP models are proposed in evaluating CMS implementation dimensions and factors. The results are validated using sensitivity analysis.FindingsThese models give firms a straightforward and simple to utilize way to deal with CMS efficiently. The two strategies were appeared to be powerful in choosing a strategy for CMS implementation. The two strategies brought about nearly similar outcomes. Both methods consider the particular necessities of the organization through its own accessible ability.Practical implicationsThe techniques exhibited in this paper can be utilized by a wide range of organizations for adopting CMS that have a higher impact on performance and thus overall productivity. The two techniques are explained in a step-by-step approach for easier adoption by practitioners.Originality/valueThe strength of the present study is that it is one of the first few to be conducted in perspective for CM implementation factors analysis.
ADVANCE Scholar Program: enhancing minoritized scholars’ professional visibility
Authors: Carter-Sowell Adrienne R. , Vaid Jyotsna , Stanley Christine A. , Petitt Becky , Battle Jericka S. 
Published: February 2019

PurposeThe purpose of this paper is to describe a mentoring program developed at a large predominantly white research university that was aimed at retaining and advancing women faculty of color. The ADVANCE Scholar Program pairs each scholar for two years with a senior faculty member at the university who serves as an internal advocate, and with an eminent scholar outside the university who helps the scholar gain prominence in their discipline.Design/methodology/approachThis paper offers a case study of the ADVANCE Scholar Program. The authors describe the intersectional approach to organizational change in this conceptual framework and provide a brief overview of the institution and precursors to the development of the Scholar program. The authors describe the program itself, its rationale, structure and participants in the program.FindingsOverall, the program generated a positive reception and outcomes, and the authors suggest that such a program has the potential to make a positive difference in making the university a more supportive place for a diverse professoriate and recommend it as a model for adoption at other predominantly white research universities.Practical implicationsBy publishing the operations and the outcomes of this faculty mentoring program, we expect to contribute broadly to a more supportive campus climate for a diverse professoriate. We have developed, implemented, and continue to study this successful model to retain minoritized faculty scholars in the professoriate.Social implicationsWomen faculty of color are often assigned to serve on committees to meet diversity objectives of the institution and are sought after by students of color from across the university, but this service is not considered. This program, the ADVANCE Scholar Program, pairs each scholar with a senior faculty member who serves as an internal advocate, and an external eminent scholar who guides the scholar in gaining national prominence. These efforts to retain and promote minoritized faculty scholars, altogether, have important implications on the pervasive issues affecting many members of academic communities at the individual, interpersonal and the institutional levels.Originality/valueThis case study provides an innovative strategy to tackle the lack of role models and the experiences of social isolation that occurs for women faculty of color with multiply marginalized status. Hence, women faculty of color benefit from a valuable, institutionally supported, university-wide mentoring program designed to increase diversity of minoritized faculty in the professoriate ranks.
Constructions of inclusion at two senior nursing home units in Sweden: immigrants’ perspectives
Authors: Hamrin Solange Barros de Alcantara 
Published: February 2019

Purpose
This study is an inductive exploration of factors that are relevant to the inclusion and integration of immigrant workers in a Swedish workplace. The purpose of this paper is to examine the experiences of immigrant employees with other organisational actors at two senior nursing units in Sweden.

Design/methodology/approach
Results are drawn from the analyses of interviews with six female and three male immigrant nursing assistants living permanently in Sweden.

Findings
Trustful relationships with other organisational actors, during both formal and informal interactions, are considered essential facilitating inclusion of these immigrant workers. Immigrant workers experienced inclusion when they achieved language competence (or felt supported in their attempts to do so) and bridged cultural differences. The results also highlight conditions for interactions and leadership as factors influencing inclusion. In addition, inclusion implied acculturation or awareness of the values of native-born citizens.

Research limitations/implications
The study suggests that immigrants’ relational dynamics with their colleagues are essential to inclusion, despite types of studies that focus mainly on the competences of leaders to manage diversity.

Practical implications
The results have implications for organisations’ development of a more democratic workplace with more inclusiveness and with satisfied employees.

Originality/value
The study gives voice to immigrant workers, which is rare in Swedish and international organisations that deal with the issue of immigrant integration in the workplace.
Internal branding and employees’ brand outcomes: do generational differences and organizational tenure matter?
Authors: Dechawatanapaisal Decha 
Published: February 2019

PurposeThe purpose of this paper is to investigate the mediating effect of brand identification between internal branding and brand citizenship behavior as well as brand loyalty, and the roles of working generation and organizational tenure as moderators of the relationship between internal branding and brand identification.Design/methodology/approachThis research used a survey method and a structured questionnaire to collect data from salespeople working in the cement and construction materials industry. The hypothesized relationships were tested and analyzed by means of a confirmatory factor analysis, structural equation modeling, hierarchical regression and a bootstrapping procedure.FindingsBrand identification partially mediates the link between internal branding and brand citizenship behavior and fully mediates that between internal branding and brand loyalty. Also, the influences of internal branding on brand identification are varied among generational cohorts and employees with different tenure.Research limitations/implicationsThe current research took place among customer-interface employees, which can be extended to back-end or supporting workers, in order to better reflect the overall effect of internal branding efforts.Practical implicationsOrganizations need to undertake internal branding to induce a shared understanding among employees about brand insights, and to foster their perception of belongingness in order to motivate desired brand behaviors. Furthermore, managers may improve internal branding mechanisms by taking generational differences and duration of employment into consideration, since these factors impinge on the effects of internal branding.Originality/valueThis study contributes to internal branding research by addressing the contingent influences of employees’ differences on the success of internal branding efforts.
User experiences in live video streaming: a netnography analysis
Authors: Wang Yi-Sheng 
Published: February 2019

Purpose
The purpose of this paper is to conduct an in-depth exploration of the special context and user experiences of live video streaming and to provide insights regarding an interpretation of the contextualization experiences model.

Design/methodology/approach
This study used netnography, online interviews and the physical travel of researchers to the field for field participation and observations. The combination of netnography and online interviews combined online and offline studies to achieve greater consistency in the data collection, analysis and other processes.

Findings
The findings of the study can be classified into a three-stage situational context approach, which is presented in the form of propositions. Finally, the insights of the contextualization experiences model are presented.

Originality/value
This study resulted in the development of a substantive theory that provides insight into interpreting the contextualization experiences model. The theory was developed based on raw data to enable it to explain the phenomena in the context of similar instances of live video streaming.