bluuebunny/crossref_metadata_2025_split huggingface dataset:
APAKAH FILOSOFI PENDIDIKAN GURU MEMPENGARUHI LITERASI DIGITAL? EFEK MEDIASI RESISTENSI TERHADAP PERUBAHAN
Authors: Terusianita Elisabeth , Radiana Usman , Dewi Nur Oktavianti , Wicaksono Luhur 
Published: December 2024

ABSTRAKPerkembangan pada zaman teknologi digital telah membawa dampak signifikan dalam berbagai aspek kehidupan, termasuk pendidikan. Literasi digital menjadi salah satu kemampuan penting yang harus dimiliki oleh para guru dalam menghadapi tantangan abad ke-21. Literasi digital mencakup keterampilan dalam menggunakan teknologi, memproses informasi digital, dan berkomunikasi melalui media digital. Di sisi lain, filosofi pendidikan yang dipegang oleh guru juga memainkan peran penting dalam bagaimana mereka mendekati pembelajaran, termasuk penggunaan teknologi digital.Artikel ini akan mengeksplorasi apakah filosofi pendidikan yang dianut oleh guru mempengaruhi literasi digital mereka, dengan melihat efek mediasi dari resistensi terhadap perubahan. Apakah guru dengan filosofi pendidikan yang lebih terbuka terhadap pembelajaran konstruktivis lebih mudah menerima dan meningkatkan literasi digital mereka? Atau apakah resistensi terhadap perubahan menjadi penghalang utama bagi pengembangan keterampilan digital mereka?Kata Kunci: Filosofi Pendidikan, Literasi Digital, Mediasi Resistensi ABSTRACTDevelopments in the era of digital technology have had a significant impact on various aspects of life, including education. Digital literacy is one of the important skills that teachers must have in facing the challenges of the 21st century. Digital literacy includes skills in using technology, processing digital information, and communicating via digital media. On the other hand, the educational philosophy held by teachers also plays an important role in how they approach learning, including the use of digital technology. This article will explore whether the educational philosophy held by teachers influences their digital literacy, by looking at the mediating effect of resistance to change. Are teachers with an educational philosophy that is more open to constructivist learning more receptive to and improving their digital literacy? Or is resistance to change a major barrier to developing their digital skills?Keywords: Filosofi Pendidikan, Literasi Digital, Mediasi Resistensi
PERAN FILSAFAT PENDIDIKAN DALAM MENGHADAPI TANTANGAN PENDIDIKAN DI ERA DIGITAL
Authors: Mora Andreas , Radiana Usman , Paranita Wira , Wicaksono Luhur 
Published: December 2024

ABSTRAK Penelitian ini bertujuan untuk menjelaskan peran penting filsafat pendidikan dalam dunia pendidikan, terutama dalam menghadapi tantangan di era digital. Filosofi pendidikan menganggap pendidikan sebagai sebuah proses perlunya memanusiakan siswa agar mereka dapat merealisasikan potensi yang ada pada diri manusia itu sendiri. Perkembangan teknologi memaksa setiap siswa untuk lebih mengembangkan potensi mereka ke arah penggunaan teknologi. Penting bagi guru untuk memikirkan cara inovatif di mana pembelajaran dapat dilakukan baik untuk meningkatkan afektif, kognitif, dan psikomotorik siswa. Dalam era digital saat ini, digitalisasi dalam pembelajaran menjadi kebutuhan untuk meningkatkan kualitas proses Pendidikan yang ada. Untuk itu pelatihan-pelatihan sangat dibutuhkan dalam mengembangkan sumber daya manusia dalam hal ini adalah guru itu sendiri.Kata Kunci: Filsafat Pendidikan Era DigitalABSTRACTThis study aims to explain the important role of educational philosophy in the world of education, especially in facing challenges in the digital era. Educational philosophy considers education as a process of the need to humanize students so that they can realize the potential that exists in humans themselves. The development of technology forces every student to further develop their potential towards the use of technology. It is important for teachers to think of innovative ways in which learning can be carried out both to improve students' affective, cognitive, and psychomotor skills. In today's digital era, digitalization in learning is a necessity to improve the quality of the existing education process. For this reason, training is needed in developing human resources in this case the teachers themselves.Keywords: Educational Philosophy Digital Era
PENGEMBANGAN E-MODUL INTERAKTIF BERBASIS STEM MATERI UNSUR, SENYAWA, CAMPURAN UNTUK MENINGKATKAN KETERAMPILAN ABAD 21 SISWA SMP KELAS VIII
Authors: Indriyati Tri Novita , Dike Daniel , Sekarwinahyu Mestika 
Published: December 2024

ABSTRAKPendidikan harus mampu menyiapkan peserta didik menghadapi abad 21. Untuk menciptakan pembelajaran abad 21 guru dapat menerapkan pendekatan STEM dan mengintegrasikan teknologi dalam proses pembelajaran misalnya dengan E-Modul berbasis STEM. Tujuan penelitian ini untuk mengetahui pengembangan E-Modul interaktif berbasis STEM materi unsur, senyawa, campuran yang valid, praktis, dan efisien dalam meningkatkan keterampilan abad 21 siswa SMP kelas VIII. Penelitian yang dilakukan merupakan penelitian R & D dengan model ADDIE. Tahapan ADDIE antara lain Analyze, Design, Develop, Implement dan Evaluate. Sebelum diimplementasikan dalam pembelajaran maka E-Modul terlebih dahulu divalidasi. Berdasarkan hasil validasi oleh ahli dan uji praktisi maka E-Modul dinyatakan layak dan sangat baik untuk digunakan. Selanjutnya dilakukan uji terbatas oleh 12 peserta didik dan E-Modul dinyatakan sangat baik. Tahapan selanjutnya yaitu tahap implementasi E-Modul dalam skala luas pada kelas VIII SMPN 3 Tempunak. Berdasarkan analisis N-Gain diperoleh hasil bahwa E-Modul interaktif berbasis STEM efektif meningkatkan keterampilanan abad 21 peserta didik.Kata Kunci: E-Modul interaktif, STEM, keterampilan abad 21ABSTRACTEducation must capable prepare participant educate face 21st century . For create learning 21st century teachers can apply STEM approach and integrate technology in the learning process for example with E- Module STEM based . Goal study This For know E- Module development interactive STEM based materials elements , compounds , mixtures that are valid, practical , and efficient in increase skills 21st century junior high school students in grade VIII. The research conducted is R & D research with the ADDIE model. The stages of ADDIE include Analyze , Design, Develop, Implement and Evaluate . Before implemented in learning then E- Module moreover formerly validated . Based on results validation by expert And test practitioner then E- Module stated worthy And very Good For used . Next done test limited by 12 participants educate and E- Module stated very Good . Stages furthermore that is stage E- Module implementation in scale wide on class VIII of SMPN 3 Tempunak . Based on N-Gain analysis is obtained results that E- Module interactive effective STEM based increase skills 21st century participants educate Keywords: Interactive E-Module, STEM, 21st Century Skills
PENGEMBANGAN BAHAN AJAR INTERAKTIF BERBASIS KOMPUTER KELAS 4 SD/MI
Authors: Srirapika Nida , Halidjah Siti , Pranata Rio 
Published: December 2024

ABSTRAKPenelitian ini bertujuan untuk mengembangkan dan menghasilkan produk bahan ajar interaktif dengan mengkolaborasikan teknologi digital yakni berbasis komputer yang layak dan praktis untuk digunakan di MIN 3 Pontianak. Penelitian ini menggunakan pendekatan penelitian dan pengembangan (Research and Development) dengan metode yang mengadopsi model dari Thiagarajan, 4D yakni Define (pendefinisian), Design (perancangan), Development (pengembangan), Dissemination (penyebarluasan). Teknik pengumpulan data penelitian ini berupa observasi, kuesioner atau angket, wawancara dan dokumentasi. Sumber data penelitian ini adalah hasil angket respons siswa. Berdasarkan hasil angket respon siswa pada kelayakan mendapatkan persentase rata-rata bahan ajar interaktif berbasis komputer sebenar 98% dengan kualifikasi sangat layak. Dan kepraktisan mendapatkan persentase rata-rata bahan ajar interaktif berbasis komputer adalah 98% dengan kualifikasi sangat praktis. Berdasarkan hasil penelitian ini dapat disimpulkan bahwa pengembangan bahan ajar interaktif berbasis komputer di kelas 4 MIN 3 Pontianak layak digunakan.Kata Kunci: Pengembangan, Bahan ajar, Interaktif, KomputerABSTRACTThis study aims to develop and produce interactive teaching material products by collaborating digital technology, namely computer-based, which are feasible and practical for use at MIN 3 Pontianak. This research uses a research and development approach with a method that adopts Thiagarajan's 4D model, namely Define, Design, Development, Dissemination. The data collection techniques of this research are observation, questionnaires or questionnaires, interviews and documentation. The data source of this research is the results of student response questionnaires. Based on the results of the student response questionnaire on the feasibility of getting the average percentage of real computer-based interactive teaching materials 98% with very feasible qualifications. And the practicality of getting the average percentage of computer-based interactive teaching materials is 98% with very practical qualifications. Based on the results of this study, it can be concluded that the development of computer-based interactive teaching materials in class 4 MIN 3 Pontianak is feasible to use.Keywords: Development, Interactive, Teaching Materials, Computer
Peran Persepsi Harga Dalam Memoderasi Hubungan Kualitas Produk terhadap Keputusan Pembelian Air Minum Dalam Kemasan (AMDK) Dikalangan Generasi Z: Bukti dari Kajian Systematic Literature Review
Authors: Ramdhan Muhamad , Djuniardi Dede 
Published: December 2024

Bottled drinking water (AMDK) has become a basic need for people in Indonesia. Consumers when choosing AMDK consider various factors, including product quality and price. Many companies that produce bottled drinking water have to compete to get their products chosen by consumers. Generation Z, when deciding to purchase a product, looks at various aspects such as product quality and price as factors to consider. So a review is needed journal papers which discusses product quality on purchasing decisions with price perceptions as a moderation that strengthens this relationship. Method used in this research are Systematic Literature Review (SLR), which focuses on journal articles published from 2019 to 2023. This study sets three research questions (Research Questions, RQ). The focus of this research is on bottled drinking water producers in the hope that it can help understand consumer behavior and implement appropriate strategies to increase product sales.
Rehabilitation of chronic post-stroke visual field defect with	computer-assisted training
Authors: Julkunen Laura , Tenovuo Olli , Jääskeläinen Satu , Hämäläinen Heikki 
Published: December 2024

Purpose. Our aim was to study whether homonymous visual field defects could be restored in chronic stroke patients (N = 5) using computer-assisted training, and whether the possible beneficial effect could be maintained. Visual evoked potential (VEP) recordings were applied to evaluate whether they could demonstrate the possible training effects at the cortical level. Methods. We applied a specially designed computer program in the training. Subjective assessment, static and kinetic perimetry, and pattern reversal hemifield VEP recordings were used to detect the possible changes. Results. Two patients showed improvements immediately after the training in static perimetry. Further improvements were detected at a later follow-up in three patients. With kinetic perimetry, improvements were detected in three patients. The visual field defect was detected with VEP recordings in four patients before the training, and improvements could be verified with the method in three patients, two of which clearly improved in the static perimetry as well. Conclusions. In three patients, the visual defect diminished with the computer-assisted method. It seems evident that visual field defects resulting from stroke can be partially restored even in the chronic phase.
CGP 3466 increases survival of cultured fetal dopaminergic	neurons
Authors: Matarredona Esperanza R. , Meyer Morten , Seiler Rolf W. , Widmer Hans R. 
Published: December 2024

Purpose: To analyze the effects of CGP 3466, a compound structurally related to deprenyl, on survival and function of fetal ventral mesencephalic dopaminergic neurons. Methods: Free-floating roller tube (FFRT) cultures of rat (E14) ventral mesencephalon were treated with CGP 3466 [10-8 M] for 7 days. Tyrosine hydroxylase (TH) and glial fibrillary acidic protein (GFAP) immunocytochemistry was performed to allow analysis of dopaminergic neurons and astroglial cells, respectively. Lactate dehydrogenase activity in the culture medium served as a measure of cell death. Control and CGP 3466 treated cultures were grafted into 6-hydroxydopamine-lesioned rats, and graft survival and function evaluated 9 weeks posttransplantation. Results: FFRT cultures treated with CGP 3466 contained significantly more (two fold) surviving TH-immunoreactive (-ir) neurons and decreased lactate dehydrogenase activity in the culture medium compared to controls. The actions of CGP 3466 seem not to be mediated by astroglial cells, since GFAP-ir cell numbers and GFAP protein levels did not differ between the groups. CGP 3466 pretreatment of donor cultures did not improve TH-ir cell survival in the grafts nor did it alter functional recovery as compared to controls. Conclusions: CGP 3466 is an effective survival factor for cultured midbrain dopaminergic neurons. However, CGP 3466 pretreatment does not ameliorate survival and function of the dopaminergic neurons after grafting into a rat model of Parkinson's disease.
Activation of A$_3$ receptors by endogenous	adenosine inhibits synaptic transmission during hypoxia in rat cortical	neurons
Authors: Hentschel S. , Lewerenz A. , Nieber K. 
Published: December 2024

Purpose: The aim of our study was to characterize the influence of A $_3$ receptors on synaptic potentials (PSPs) in pyramidal cells from the rat cingulate cortex during hypoxia. METHODS: Intracellular recordings ($n=49$) were taken from slice preparations. PSPs were evoked by electrical stimulation. Results: Hypoxia (95%NA $_2$ -5%COA $_2$ , 5 min) reduced the amplitude of the PSPs significantly. The effect was more pronounced in the presence of adenosine re-uptake inhibitor S-(p-nitrobenzyl)-6-thioguanosine (NBTG) and deaminase inhibitor erythro-9-(2-hydroxy-3-nonyl)adenine (EHNA); the effect was completely reversed by bovine adenosine deaminase. Hypoxic inhibition induced after A $_1$ receptor blockade with 1,3-dipropyl-8-cyclopentylxanthine (DPCPX) in the presence of NBTG was completely reversed by the A $_3$ antagonist 9-chloro-2-(2-furanyl)-5-[(phenylacetyl)amino]-1,2,4-triazolo[1,5-c]quinazoline (MRS 1220), indicating the involvement of A $_3$ receptors in hypoxic PSP inhibition. This was confirmed by A $_3$ agonist NA $^6$ -(3-iodobenzyl)-adenosine-5'-N-methylcarboxamide (IB-MECA) inhibiting PSPs. The effect of IB-MECA was blocked by the rat A $_3$ receptor-selective antagonist 3-propyl-6-ethyl-5-[(ethylthio)carbonyl]-2-phenyl-4-propyl-3-pyridinecarboxylate (MRS 1523) and was not observed in the presence of G-protein inhibitor guanosine-5'-O-2-thiodiphosphate (GDP-β-S). Conclusion: We conclude that a high level of endogenous adenosine, which occurs during hypoxia, activates A $_3$ receptors. Their activation contributes to PSP inhibition by adenosine during hypoxia.
Dimeric fibroblast growth factor-2 enhances functional recovery	after focal cerebral ischemia
Authors: Berry David , Ren JingMei , Kwan Chi-Pong , Sietsma Dana K. , Sasisekharan Ram , Finklestein Seth P. 
Published: December 2024

Purpose: The purpose of this study was to examine the effects of dimerized basic fibroblast growth factor (dFGF), a novel engineered growth factor, in a model of functional recovery following focal cerebral infarction (stroke) in rats. Methods: A focal stroke was made in mature male rats by occlusion of the middle cerebral artery (MCA). dFGF was administered by intracisternal injection at one and three days after stroke. Tests to evaluate sensorimotor recovery of the contralateral limbs were done during the next three weeks after stroke. Results: dFGF significantly enhanced recovery of sensorimotor function in limb placing and body swing tests compared to vehicle treatment. There were no differences in body weight or infarct volume in dFGF- vs. vehicle-treated animals. Conclusions: dFGF represents a potential treatment to enhance functional recovery after stroke and offers several advantages over bFGF, including stability and independence from extracellular heparan sulfates.
A genetic fusion GDNF-C fragment of tetanus toxin prolongs	survival in a symptomatic mouse ALS model
Authors: Ciriza J. , Moreno-Igoa M. , Calvo A.C. , Yague G. , Palacio J. , Miana-Mena F.J. , Muñoz M.J. , Zaragoza P. , Brûlet P. , Pinzolas R. y Osta 
Published: December 2024

Purpose: Amyotrophic Lateral Sclerosis (ALS) is a paralyzing disorder that kills individuals within three to five years of onset without any possibility for effective treatment. One proposed therapy has been the use of neurotrophic factors to inhibit the apoptosis of motorneurones. At the present, one way to deliver neurotrophic factors after intramuscular injection to the motor neurones is through the use of adenoviral vectors. An alternative strategy is the use of the atoxic C fragment of tetanus toxin (TTC) as a neurotrophic factor carrier for motorneurones. Methods: We have produced the recombinant protein fusion Glial Derived Neurotrophic Factor and C fragment of tetanus toxin (GDNF-TTC) and we have tested its antiapoptotic activity in degeneration culture cells and in the symptomatic SOD $^{G93A}$ transgenic animal model for ALS. Results: We demonstrated that GDNF-TTC induces the neuronal survival Akt kinase pathway in mouse cortical culture neurons and~maintains its antiapoptotic neuronal activity in Neuro2A cells. Moreover, we have found that genetic fusion is able to increase survival by 9 days and improves life quality in symptomatic ALS animal models. Conclusion: These results suggest that recombinant GDNF-TTC fusion protein intramuscular injections provide a potential therapy for ALS treatment.
Neural correlates of recovery from acute hemispatial	neglect
Authors: Thimm M. , Fink G.R. , Sturm W. 
Published: December 2024

Purpose: To investigate the neural correlates associated with recovery from acute spatial neglect resulting from right hemispheric stroke. Methods: Four neglect patients were investigated both behaviourally and by fMRI at an acute (18 ± 5 days) and at a chronic stage (123 ± 18 days) post stroke. Results: At the second assessment all patients showed substantial behavioural improvements. These were associated with an increase of neural activity in the right middle frontal gyrus, right inferior parietal cortex, right inferior temporal gyrus/fusiform gyrus, left superior temporal gyrus/angular gyrus and left anterior cingulate gyrus. Decreased neural activity at the second assessment was found in the right parahippocampal gyrus and left fusiform gyrus. Conclusions: The pattern of neural reorganisation comprises areas of a right hemisphere fronto-parietal attentional network and corresponding left hemisphere areas suggesting a compensatory recruitment of analogous contralesional areas. Interestingly, a more complex pattern of neural changes was observed in the fusiform gyri which have previously been implicated in lateralised directed spatial attention. There was an increase in the right hemisphere and a decrease in the left hemisphere. This pattern of recovery is reminiscent of a "push-pull" pattern previously described for the dorsal parietal cortex by Corbetta et al. (2005) in the recovery from spatial neglect.
Transplantation of embryonic neurones to replace missing spinal	motoneurones
Authors: Nógrádi Antal , Szabó András 
Published: December 2024

Loss of spinal motoneurones results in severe functional impairment. The most successful way to replace missing motoneurones is the use of embryonic postmitotic motoneurone grafts. It has been shown that grafted motoneurones survive, differentiate and integrate into the host cord. If grafted motoneurones are provided with a suitable conduit for axonal regeneration (e.g. a reimplanted ventral root) the grafted cells are able to grow their axons along the whole length of the peripheral nerves to reach muscles in the limb and restore function. Grafted motoneurones show excellent survival in motoneurone-depleted adult host cords, but the developing spinal cord appears to be an unfavourable environment for these cells. The long term survival and maturation of the grafted neurones are dependent on the availability of a nerve conduit and one or more target muscles, no matter whether these are ectopic nerve-muscle implants or limb muscles in their original place. Thus, grafted and host motoneurones induce functional recovery of the denervated limb muscles when their axons regenerate into an avulsed and reimplanted ventral root. On the other hand, motoneurone-enriched embryonic grafts placed into a hemisection cavity in the cervical spinal cord induce axonal regeneration from great numbers of host motoneurones, possibly by the bridging effect of the grafts. In this case the regenerating host motoneurones reinnervate their original target muscles while the graft provides few axons for the reinnervation of muscles. These results suggest that reconstruction of the injured spinal cord with embryonic motoneurone-enriched spinal cord graft is a feasible method to improve severe functional motor deficits.
Retrograde viral transduction of cortical pyramidal neurons from	the spinal cord
Authors: Groutsi F. , Mason M.R.J. , Anderson P.N. , Martins S. , Anesti M. , Coffin R.S. , Campbell G. 
Published: December 2024

Purpose: The primary motor pathway, the corticospinal tract, is a major target for spinal cord regeneration studies. One way of improving the regeneration of corticospinal axons is to introduce regeneration-associated genes into cortical motor neurons using viral vector delivery. Methods: We used an engineered Herpes Simplex virus (HSV1) with the EF1α promoter encoding either LacZ or GFP to transduce cortical neurons through retrograde transport following the injection of vector into adult rat striatum or spinal cord. After three-days to one-month post-injection, sections of brain and spinal cord were viewed with fluorescence microscopy or processed for LacZ histochemistry. Results: Many layer V motor cortical neurons were transduced following striatal injections. These were not corticospinal neurons as they were not fluorogold-labelled following tracer injection into spinal cord. Corticospinal neurons in both hemispheres were, however, transduced following direct vector injections into the dorsal column of spinal cord, yielding 250–400 transduced corticospinal neurons per animal. No non-pyramidal neurons or thalamic neurons were transduced by spinal injections. Conclusions: Therefore, this HSV1.EF1α vector is highly effective for the transduction of corticospinal neurons without direct injection into the brain and could be used to introduce regeneration-relevant genes into these neurons with the aim of regenerating the corticospinal tract.