bluuebunny/crossref_metadata_2025_split huggingface dataset:
Multivariate resting-state functional connectivity predicts response to cognitive behavioral therapy in obsessive–compulsive disorder
Authors: Reggente Nicco , Moody Teena D. , Morfini Francesca , Sheen Courtney , Rissman Jesse , O’Neill Joseph , Feusner Jamie D. 
Published: February 2018

SignificanceThe ability to predict an individual’s potential response to treatment would permit clinicians to more prudently allocate resources that support cognitive behavioral therapy for obsessive–compulsive disorder (OCD), an often stressful and time-consuming treatment. The current study lays important groundwork for an exciting advance toward personalized medicine in psychiatry that up to this point has eluded the field. This study marks a success in using multivariate pattern recognition to identify neurobiological predictors of treatment response. In addition, it advances knowledge of the neurophysiology of OCD and of mechanistic processes involved in the therapeutic response, which could be used to refine existing treatments or to develop novel treatments based on identified potential brain targets.
Cancer-secreted hsa-miR-940 induces an osteoblastic phenotype in the bone metastatic microenvironment via targeting ARHGAP1 and FAM134A
Authors: Hashimoto Kyoko , Ochi Hiroki , Sunamura Satoko , Kosaka Nobuyoshi , Mabuchi Yo , Fukuda Toru , Yao Kenta , Kanda Hiroaki , Ae Keisuke , Okawa Atsushi , Akazawa Chihiro , Ochiya Takahiro , Futakuchi Mitsuru , Takeda Shu , Sato Shingo 
Published: February 2018

Significance
Prostate cancer is one of most common cancers in men worldwide, and osteoblastic bone metastasis is frequently observed in prostate cancer patients. However, the mechanisms responsible for the predominantly osteoblastic phenotype have not been fully elucidated. Cancer-secreted microRNAs (miRNAs) were recently shown to be significant in the modification of the tumor microenvironment. Here, hsa-miR-940, which was highly secreted by prostate cancer cells, promoted osteogenic differentiation of human mesenchymal stem cells in vitro, and induced extensive osteoblastic lesions in the bone metastatic microenvironment in vivo. Our study provides a demonstration that osteoblastic bone metastasis can be induced by miRNAs secreted by cancer cells in the bone microenvironment.
Bryostatin-1 alleviates experimental multiple sclerosis
Authors: Kornberg Michael D. , Smith Matthew D. , Shirazi Hasti Atashi , Calabresi Peter A. , Snyder Solomon H. , Kim Paul M. 
Published: February 2018

Significance
Multiple sclerosis (MS) is an inflammatory disease that targets the central nervous system and leads to severe neurologic disability. Bryostatin-1 is a naturally occurring, brain-penetrant compound that has undergone human testing in cancer and Alzheimer’s disease, but also has immunomodulatory properties that might provide benefit in MS. Here, we show that bryostatin-1 potently prevents disease and reverses neurologic deficits in the major mouse model of MS, experimental autoimmune encephalomyelitis (EAE). Its benefit even in late-stage EAE further suggests potential in progressive forms of MS, in which much disability accrues but treatments are currently lacking. The established clinical safety profile of bryostatin-1 in humans could expedite its development as a therapeutic agent in MS.
Death-domain dimerization-mediated activation of RIPK1 controls necroptosis and RIPK1-dependent apoptosis
Authors: Meng Huyan , Liu Zhen , Li Xingyan , Wang Huibing , Jin Taijie , Wu Guowei , Shan Bing , Christofferson Dana E. , Qi Chunting , Yu Qiang , Li Ying , Yuan Junying 
Published: February 2018

Significance
While the critical role of RIPK1 kinase activity in mediating necroptosis and RIPK1-dependent apoptosis has been established, we still know little about how the nonkinase domains of RIPK1 regulate its kinase activity. Establishing the role of RIPK1-death domain (DD) in mediating RIPK1 activation and formation of complex II provides an important insight into the molecular mechanism by which RIPK1 is activated during the transition from complex I to complex II. These results suggest that RIPK1-DD self-association may provide an amplification mechanism to promote the activation of RIPK1 kinase activity for mediating signal transduction to lead to cell death. Our results also suggest that the activation of RIPK1 may be regulated by its concentration as increased expression of RIPK1 under pathological conditions may promote its dimerization and activation.
Afro-Hispanic contact varieties at the syntax/pragmatics interface
Authors: Sessarego Sandro , Gutiérrez-Rexach Javier 
Published: February 2018

Abstract
The Null Subject Parameter (NSP) has been the focus of much debate in the syntactic and pragmatic literature. Within the realm of Spanish and Portuguese, the analysis of two dialects that do not follow its predictions (Dominican Spanish (DS) and Brazilian Portuguese (BP)) has led to the postulation of new hypotheses to account for their unexpected syntactic patterns. The present study pays attention to yet another dialect of Spanish that does not conform to the NSP, Chinchano Spanish (CS), an Afro-Hispanic variety spoken in Chincha, Peru. In so doing, this paper provides an analysis of null and overt subjects that partially deviates from previous accounts of similar pro-drop phenomena. Additionally, this study proposes a model of contact-induced language transmission that explains why CS – as well as many other Afro-Hispanic languages of the Americas (AHLAs) – presents patterns that do not align this dialect with either null-subject languages (NSLs) like Italian or non-null-subject languages (NNSLs) like English.
Hasta perder la última gota de mi sangre
Authors: King Jeremy 
Published: February 2018

Abstract
In spite of the recent burgeoning of the field of Spanish socio-pragmatics, the category of commissive speech acts has been all but ignored in scholarship, particularly in contact varieties of the language. Colonial Louisiana presents an ideal context for this type of work. The analysis herein involves a corpus of 100 business letters between Spanish government and military officials in 18th century Louisiana. All commissive speech acts were identified and coded according to a modified version of the taxonomy presented in Bilbow (2002). Results of the study reveal that the level of power of the speaker (= letter writer) proved to be the most significant factor in the formulation of commissives. The level of relative power of a speaker appeared to guide not only the general type of commissives employed (e.g., promises vs. offers) but also the specific morphological expression of the speech act (e.g., future vs. present tense).
L2 Spanish in the U.S. and the question of motivation
Authors: Schroth Terri , Smith Bryant 
Published: February 2018

Abstract
University students’ motivation to study Spanish includes a number of practical or instrumental factors (e.g., ease in finding gainful employment and desire to travel) and intrinsic or integrative factors (e.g., personal growth and using Spanish to communicate with family and friends). To better understand students’ current motivation to study Spanish, we examined data collected from university students of lower-division Spanish language courses from two different geographical regions in the United States. The participants completed questionnaires that sought to determine their motivation for studying Spanish. Concurrent with our hypothesis, results of this pilot study indicate that the students of Spanish who participated in this study express more practical (instrumental) motivations to learn the language. A desire to connect with one’s heritage or to speak Spanish with family members proved to be a less important motivator than we had anticipated, as did the geographic region of the students.
Espero estén todos
Authors: Rodríguez-Riccelli Adrián 
Published: February 2018

Abstract
This study adopts a quantitative methodology to investigate variation between null and overt expressions of Spanish complementizer que. I focus on two varieties of Spanish from Mexico City and Los Angeles, California. This research uses a corpus linguistics–inspired methodology, relying on Twitter as a database to extract tokens and Rrbul (Johnson 2008) to perform the multivariate analysis. I extracted and analyzed 1,505 tokens and coded for 9 linguistic and 2 extra-linguistic factors. I showed the internal factors ‘verb modality’ and ‘embedded subject status’ to significantly affect the alternation, favoring the null option. Contrary to what was expected, the external factor ‘city’ did not have any significant effect on the distribution. I discuss the results in light of formal and sociolinguistic studies on the nature of subordinated constructions in Spanish (Brovetto 2002; Etxepare 1996; Subirats-Rüggeberg 1987), English (Tagliamonte & Smith 2005) and Spanish in contact with English (Silva-Corvalán 1993, 1994, 1998).
A usage-based account for the historical reflexes of
ain’t in AAE
Authors: Smith K. Aaron 
Published: February 2018

Abstract
This paper is a comparative and historical study of the grammatical status of
auxiliary ain‘t in African-American English (AAE). Drawing
on the representation of AAE speakers in works of fiction from the 19th
century and present-day, the paper confirms that the broad range of uses of
auxiliary ain‘t are nearly all available in historical AAE.
The study also presents data that certain of the uses (specifically those
not documented or only infrequently documented for non-AAE varieties) have
increased in fictive representations of AAE. The analysis shows that the
increase is led by a specific verb type (and even a specific verb) and thus
suggests an exemplar-based increase and extension of ain‘t.
Moreover, the paper also shows a formal morphosyntactic convergence of
several uses of auxiliary ain‘t and motivates that
convergence through exemplar merging, suggesting an association of that
merged morphosyntactic form with sociolinguistic identity.
look
up about
Authors: Nordquist Dawn 
Published: February 2018

Abstract
This chapter investigates the emergence of a new English
phrasal-prepositional verb, look up about, which is found
predominantly in online discourse and is largely synonymous with “to
google”. It is argued that the verb emerged as the result of a reanalysis of
a source syntagm that eroded an internal constituency boundary and resulted
in a new lexical item. In order to understand how reanalysis took place in
the lexicalization of look up about, usage-based processes
such as chunking and holistic and heuristic-based processing are examined,
and Bybee’s (2002) Linear Fusion Hypothesis is also invoked to explain how
this multi-word expression has entered the lexicon of many users.
Retention of Student Pharmacists’ Knowledge and Skills regarding Overdose Management with Naloxone
Authors: Jacobson Anita N. , Bratberg Jeffrey P. , Monk Miranda , Ferrentino John 
Published: February 2018

Background Overdose education and naloxone training was recently implemented into the required curriculum of the College of Pharmacy at the University of Rhode Island. The objective of this study was to compare the retention of knowledge between student pharmacists who received a didactic lecture only versus student pharmacists who received the same lecture plus a skills-based objective structured clinical examination (OSCE) with a standardized patient actor. Methods Students in their first-professional year (P1) of the Doctor of Pharmacy program (n = 129) and students in their second-professional (P2) year (n = 123) attended a required lecture on opioid overdose, including detailed naloxone training. P2 students were additionally required to participate in an OSCE assessment following the didactic lecture component. An anonymous, voluntary survey was offered to all students approximately 6 months later. A Chi-Square or Fisher's Exact Test was performed on the survey responses to assess any difference in the responses between the two groups. Results A total of 99 P1 students (76.7%) and 116 P2 students (94.3%) completed the survey. P1 students were found to be more knowledgeable regarding the duration of naloxone action and identification of risk factors for opioid overdose. P2 students were found to be more knowledgeable regarding non-medical ways patients may obtain opioids and the correct order of emergency response during a suspected opioid overdose… Conclusions P2 students did not demonstrate superior retention of information regarding naloxone and opioid use disorder on survey questions compared with P1 students. There was a trend towards P2 students feeling more confident in their ability to counsel patients for overdose prevention and reporting disagreement with the statement that “overdose prevention for people who use drugs is a waste of time and money” compared with the P1 students, but these did not reach statistical significance. Since the opioid crisis continues unabated, naloxone training using OSCE and didactic methods remain an on-going required part of the pharmacy curriculum.
Results of the supplementary comparison SIM.M.FF-S12 for volume of liquids at 20 L
Authors: Maldonado M , Castillo E , Rodríguez L D 
Published: February 2018

A supplementary comparison was performed in order to compare national measurement systems to determine volume of liquids, particularly at fixed volume of 20 L. The participants were CENAM (Mexico), LACOMET (Costa Rica) and RECOPE (Costa Rica). The measurements were carried out from October 2016 to June 2017. The chosen value of volume (20 L) is representative of the Calibration and Measurement Capabilities (CMCs) declared by the three participants. The transfer standard (TS) was a stainless steel pipette for volume at 20 L. Prior to the beginning of the comparison, the TS was tested by CENAM. The results of the test phase showed excellent values for both repeatability and reproducibility. During the SIM.M.FF-S12, the results of the laboratories showed good agreement with the reference values. The best estimation of the measurands, as reported by the participants, showed a ± 0.0022 % as the largest difference among the laboratories.

Main text

To reach the main text of this paper, click on Final Report. Note that this text is that which appears in Appendix B of the BIPM key comparison database kcdb.bipm.org/.
The final report has been peer-reviewed and approved for publication by the CCM, according to the provisions of the CIPM Mutual Recognition Arrangement (CIPM MRA).
RaMWAS: fast methylome-wide association study pipeline for enrichment platforms
Authors: Shabalin Andrey A , Hattab Mohammad W , Clark Shaunna L , Chan Robin F , Kumar Gaurav , Aberg Karolina A , van den Oord Edwin J C G 
Published: February 2018

Abstract

Motivation
Enrichment-based technologies can provide measurements of DNA methylation at tens of millions of CpGs for thousands of samples. Existing tools for methylome-wide association studies cannot analyze datasets of this size and lack important features like principal component analysis, combined analysis with SNP data and outcome predictions that are based on all informative methylation sites.

Results
We present a Bioconductor R package called RaMWAS with a full set of tools for large-scale methylome-wide association studies. It is free, cross-platform, open source, memory efficient and fast.

Availability and implementation
Release version and vignettes with small case study at bioconductor.org/packages/ramwas Development version at github.com/andreyshabalin/ramwas.

Supplementary information
Supplementary data are available at Bioinformatics online.
ChemDistiller: an engine for metabolite annotation in mass spectrometry
Authors: Laponogov Ivan , Sadawi Noureddin , Galea Dieter , Mirnezami Reza , Veselkov Kirill A 
Published: February 2018

Abstract

Motivation
High-resolution mass spectrometry permits simultaneous detection of thousands of different metabolites in biological samples; however, their automated annotation still presents a challenge due to the limited number of tailored computational solutions freely available to the scientific community.

Results
Here, we introduce ChemDistiller, a customizable engine that combines automated large-scale annotation of metabolites using tandem MS data with a compiled database containing tens of millions of compounds with pre-calculated ‘fingerprints’ and fragmentation patterns. Our tests using publicly and commercially available tandem MS spectra for reference compounds show retrievals rates comparable to or exceeding the ones obtainable by the current state-of-the-art solutions in the field while offering higher throughput, scalability and processing speed.

Availability and implementation
Source code freely available for download at https://bitbucket.org/iAnalytica/chemdistillerpython.

Supplementary information
Supplementary data are available at Bioinformatics online.
Development of Proximal Junctional Kyphosis After Minimally Invasive Lateral Anterior Column Realignment for Adult Spinal Deformity
Authors: Gandhi Shashank V , Januszewski Jacob , Bach Konrad , Graham Randall , Vivas Andrew C , Paluzzi Jason , Kanter Adam , Okonkwo David , Tempel Zachary J , Agarwal Nitin , Uribe Juan S 
Published: February 2018

Abstract

BACKGROUND
Development of proximal junctional kyphosis (PJK) after correction of adult spinal deformity (ASD) undermines sagittal alignment. Minimally invasive anterior column realignment (ACR) is a powerful tool for correction of ASD; however, long-term PJK rates are unknown.

OBJECTIVE
To characterize PJK after utilization of ACR in ASD correction.

METHODS
A retrospective multi-institution cohort analysis per STROBE criteria was conducted of all patients who underwent lateral lumbar interbody fusion (LLIF) or ACR for ASD from 2010 to 2015. All patients obtained preoperative and follow-up upright radiographs, assessing spinal alignment and development of PJK. Patients without proper imaging or minimum 1-yr follow-up were excluded.

RESULTS
A total of 73 of 112 patients who underwent either LLIF or ACR for ASD met inclusion criteria. Mean follow-up was 22.8 mo. There was significant improvement of all spinopelvic parameters. Overall, PJK and proximal junctional failure (PJF) rates were 20.5% and 11%, respectively. The incidence of PJK increased with greater corrective surgery (0% LLIF, 30% ACR, 42.9% ACR + posterior column osteotomy (PCO); P < .001). PJF rates increased (0% LLIF, 11% ACR, 40% ACR + PCO; P = .005). Risk factors included location of the upper-instrumented vertebra at T10-L1 vs L2-L4 (P = .007), age (P = .029), severity of ASD, and overcorrection of sagittal imbalance.

CONCLUSION
The incidence of PJK after minimally invasive ACR is slightly lower than reported after open surgery but greater than in LLIF only and increases with PCO utilization. The PJK rate increases when crossing the TL junction, sagittal imbalance severity, and overcorrection. Elderly patients are at an increased risk, suggesting need for age appropriate correction goals.
Cognitive Functional Therapy: An Integrated Behavioral Approach for the Targeted Management of Disabling Low Back Pain
Authors: O’Sullivan Peter B , Caneiro J P , O’Keeffe Mary , Smith Anne , Dankaerts Wim , Fersum Kjartan , O’Sullivan Kieran 
Published: February 2018

Abstract
Biomedical approaches for diagnosing and managing disabling low back pain (LBP) have failed to arrest the exponential increase in health care costs, with a concurrent increase in disability and chronicity. Health messages regarding the vulnerability of the spine and a failure to target the interplay among multiple factors that contribute to pain and disability may partly explain this situation. Although many approaches and subgrouping systems for disabling LBP have been proposed in an attempt to deal with this complexity, they have been criticized for being unidimensional and reductionist and for not improving outcomes. Cognitive functional therapy was developed as a flexible integrated behavioral approach for individualizing the management of disabling LBP. This approach has evolved from an integration of foundational behavioral psychology and neuroscience within physical therapist practice. It is underpinned by a multidimensional clinical reasoning framework in order to identify the modifiable and nonmodifiable factors associated with an individual's disabling LBP. This article illustrates the application of cognitive functional therapy to provide care that can be adapted to an individual with disabling LBP.
Understanding the Etiology of Chronic Pain From a Psychological Perspective
Authors: Linton Steven J , Flink Ida K , Vlaeyen Johan W S 
Published: February 2018

Abstract
The etiology of chronic pain–related disability is not fully understood, particularly from a clinical perspective. Investigations to date have identified risk factors and elucidated some important processes driving the development of persistent pain problems. Yet this knowledge and its application are not always accessible to practicing physical therapists or other clinicians. This article aims to summarize the main psychological processes involved in the development of chronic pain disability and to derive some guidelines for treatment and future research. To this end, the focus is on the paradox of why coping strategies that are helpful in the short term continue to be used even when—ironically—they maintain the problem in the long term. To aid in summarizing current knowledge, 4 tenets that elucidate the etiology of chronic pain are described. These tenets emphasize that chronic pain disability is a developmental process over time, contextual factors set the stage for this development, underlying transdiagnostic psychological factors fuel this development, and the principles of learning steer the development of pain behaviors. With these tenets, an explanation of how a chronic problem develops for one person but not another is provided. Finally, hypotheses that can be empirically tested to guide clinical application as well as basic research are generated. In conclusion, understanding the psychological processes underlying the etiology of chronic pain provides testable ideas and a path forward for improving treatment interventions.
A Mechanism-Based Approach to Physical Therapist Management of Pain
Authors: Chimenti Ruth L , Frey-Law Laura A , Sluka Kathleen A 
Published: February 2018

Abstract
Pain reduction is a primary goal of physical therapy for patients who present with acute or persistent pain conditions. The purpose of this review is to describe a mechanism-based approach to physical therapy pain management. It is increasingly clear that patients need to be evaluated for changes in peripheral tissues and nociceptors, neuropathic pain signs and symptoms, reduced central inhibition and enhanced central excitability, psychosocial factors, and alterations of the movement system. In this Perspective, 5 categories of pain mechanisms (nociceptive, central, neuropathic, psychosocial, and movement system) are defined, and principles on how to evaluate signs and symptoms for each mechanism are provided. In addition, the underlying mechanisms targeted by common physical therapist treatments and how they affect each of the 5 categories are described. Several different mechanisms can simultaneously contribute to a patient's pain; alternatively, 1 or 2 primary mechanisms may cause a patient's pain. Further, within a single pain mechanism, there are likely many possible subgroups. For example, reduced central inhibition does not necessarily correlate with enhanced central excitability. To individualize care, common physical therapist interventions, such as education, exercise, manual therapy, and transcutaneous electrical nerve stimulation, can be used to target specific pain mechanisms. Although the evidence elucidating these pain mechanisms will continue to evolve, the approach outlined here provides a conceptual framework for applying new knowledge as advances are made.