bluuebunny/crossref_metadata_2025_split huggingface dataset:
Design, synthetic approches, structure-activity relationship strategy and antibacterial evaluation for N-alkylated derivatives with binding mode of chloroquinoline- thiazolidinedione based hybrids
Authors: Juddhawala Krunal V. , Parekh Nikhil M. 
Published: November 2024

Abstract

A variety of new compounds have been integrated into the structural framework of (5Z)-5-[(2-(4-methylpiperazin-1yl)quinoline-3-yl)methyl]-1,3-thiazolidine-2,4-dione. The synthesis of 1,3-thiazolidine-2,4-dione was accomplished by means of the condensation of 2-chloroquinoline, which later functioned as a pivotal reagent in the reaction with 3-carbaldehydes, resulting in the production of 2,4-thiazolidinedione. The characterization of these recently synthesised compounds was performed by their interactions with halide compounds, namely involving substituted N-alkylation. Chemical identification was achieved by using elemental analysis, Fourier-transform infrared spectroscopy (FT-IR), and proton nuclear magnetic resonance spectroscopy (1H-NMR). Additionally, the synthesised compounds were subjected to in vitro testing to assess their antibacterial activity against a range of pathogens, such as Staphylococcus aureus, Bacillus subtilis, Escherichia coli, and Pseudomonas aeruginosa.
Distributed Temporal Coding of Visual Memory Categories in Human Hippocampal Neurons
Authors: She Xiwei , Moore Bryan J. , Roeder Brent M. , Nune George , Robinson Brian S. , Lee Brian , Shaw Susan , Gong Hui , Heck Christianne N. , Popli Gautam , Couture Daniel E. , Laxton Adrian W. , Marmarelis Vasilis Z. , Deadyler Sam A. , Liu Charles , Berger Theodore W. , Hampson Robert E. , Song Dong 
Published: November 2024

Abstract

The hippocampus is crucial for forming new episodic memories. While the encoding of spatial and temporal information (where and when) in the hippocampus is well understood, the encoding of objects (what) remains less clear due to the high dimensions of object space. Rather than encoding each individual object separately, the hippocampus may instead encode categories of objects to reduce this dimensionality. In this study, we developed and applied a combined experimental-modeling approach to investigate how the hippocampus encodes visual memory categories in humans. We recorded spikes from hippocampal CA3 and CA1 neurons in 24 epilepsy patients performing a visual delayed match-to-sample (DMS) task involving five image categories. An ensemble multi-temporal-resolution classification model was employed to decode these visual memory categories from the hippocampal spiking activity with moderate numbers of trials. This model enables the identification of the spatio-temporal characteristics of hippocampal encoding through its interpretable representations. Using this model, we estimated the optimal temporal resolutions for decoding each visual memory category for each neuron in the ensemble. Results indicate that visual memory categories can be decoded from hippocampal spike patterns despite the short data length, supporting the presence of category-specific coding in the human hippocampus. We found that hippocampal neuron ensembles encode visual memory categories in a distributed manner, akin to a population code, while individual neurons use a temporal code. Additionally, CA3 and CA1 neurons exhibit similar and redundant information regarding visual memory categories, likely due to the strong and diffuse feedforward synaptic connections from the CA3 region to the CA1 region.
The rise of the worm: bibliometric insights into the growing significance of vermicomposting for sustainable agriculture and environmental management
Authors: Mhamdi Ridha 
Published: November 2024

Abstract

Purpose This paper presents a comprehensive bibliometric analysis of vermicomposting research over the past decade, focusing on its several advantages to sustainable agriculture and waste management.
Method The study encompasses 3259 papers published during the last decade (2013-2022), with a focus on the last five years to identify emerging trends.
Results A substantial growth in vermicomposting research is observed, with an annual publication output doubling from 2013 to 2022. Subject area analysis reveals prominence in Agricultural and Biological Sciences and Environmental Science. International collaboration has increased over the decade, with India leading in quantity but displaying a Field-Weighted Citation Impact (FWCI) below the global average. Other countries, including China, Spain, USA, and Malaysia, exhibit higher FWCI scores. Academic-corporate collaboration is limited, with only 9 papers resulting from such partnerships. Patent analysis indicates a growing interest in vermicomposting-related innovations, with 35 patents published since 2015, emphasizing sustainable practices in agriculture and waste management.
Conclusion Emerging trends encompass the development of methods for assessing vermicompost maturity and investigating its integration with other waste treatment technologies, optimization of vermicomposting through feedstock diversification, process fine-tuning, and innovative reactor designs, and environmental applications, involving the removal of heavy metals, degradation of microplastics, and wastewater treatment.
The Impact of Corporate Social Responsibility on Financial Performance, Financial Inclusion, and Financial Stability: case of Tunisia
Authors: Fatma Felhi 
Published: November 2024

Abstract

The aim of this study is to analyze how Corporate Social Responsibility (CSR) affects the financial performance, financial inclusion, and financial stability of financial institutions in Tunisia. The research focuses on data from 30 financial institutions collected annually from 2008 to 2019. The results show that CSR, along with the age and size of the institution, positively influences all three factors. On the other hand, higher levels of debt have a negative impact on financial inclusion and financial stability. Moreover, financial inclusion is negatively correlated with asset tangibility.
ЛАТЕНТНОЕ ВАРВАРСТВОПРИРОДА ЯВЛЕНИЯ, ИСТОРИЧЕСКАЯ ЭВОЛЮЦИЯ(РОССИЙСКИЙ ОПЫТ)
Authors: И.Г. ЯКОВЕНКО 
Published: November 2024

В статье, на российском материале, рассматривается природа латентного варварства. Исследуется возникновение этого феномена, его историкокультурная эволюция. Описываются значимые характеристики сознания и поведения латентного варвара. Автор предлагает культурологическую интерпретацию исследуемого явления. Особое место занимает проблема ментальности. Варвар, как и любой иной человеческий тип, задается соответствующей ментальностью. Отсюда внимание к проблеме межпоколенческого воспроизводства варварского сознания, которое задается процессами инсталляции ментальности.
In the article, on the Russian material, the nature of latent barbarism is considered. The origin of this phenomenon, its historical and cultural evolution is investigated. The significant characteristics of consciousness and behavior of the latent barbarian are described. The author offers a culturological interpretation of the phenomenon under study. A special place is occupied by the problem of mentality. The barbarian, like any other human type, is given the appropriate mentality. Hence the attention to the problem of intergenerational reproduction of barbaric consciousness, which is set by the processes of installation of mentality.
«ВАРВАРСТВО ЦИВИЛИЗАЦИИ»ЛИЦОМ К ЛИЦУС «ЦИВИЛИЗАЦИЕЙ ВАРВАРСТВА»: ФЕНОМЕН ЛАТЕНТНОГО ВАРВАРСТВА В КОНТЕКСТЕ ГРЕКО-РИМСКОЙ ЦИВИЛИЗАЦИИ I В. ДО Н.Э.(ПО ПРОИЗВЕДЕНИЯМ ЦИЦЕРОНА)
Authors: В.О. НИКИШИН 
Published: November 2024

Статья посвящена примерам латентного варварства в произведениях Цицерона. В первую очередь автор анализирует терминологию Цицерона и в результате приходит к выводу, что оратор делил все человечество на три категории, а именно греков, римлян и варваров. Кроме того, Цицерон отметил еще одну промежуточную категорию так называемых полуварваров (примеры: галлогреки и боспораны). В произведениях Цицерона мы находим примеры того, как греки (Graeculi), римляне (Пизон, Антоний, Долабелла) или эллинизированные полуварвары (Брогитар I, Кастор II) проявляют варварские свойства натуры, т.е. черты, чуждые культурному образу жизни (vita perpolita humanitate). Наконец, автор приходит к выводу, что практически во всех случаях те характеристики и оценки, которые Цицерон давал тем или иным лицам, в значительной степени зависели от его личного отношения к этим людям.
This article is devoted to the examples of latent barbarity in the works of Cicero. First of all the author analyzes the terminology of Cicero and as a result comes to a conclusion that the orator divided the whole mankind in three categories which were the Greeks, the Romans and the Barbarians. Besides that Cicero marked one else intermediate category of the socalled halfbarbarians, for example the Gallogrecs and the Bosporans. In the works of Cicero we find some examples of that the Greeks (Graeculi), the Romans (Calpurnius Piso, Antony and Dolabella) or hellenized halfbarbarians (Brogitarus I, Castor II) showed barbaric features of their proper characters, i.e. traits which were alien to the cultural way of life (vita perpolita humanitate). Finally, the author comes to a conclusion that practically in all the cases those characteristics and estimates, which Cicero gave one or another person, to a great extent depended on his own attitude to these people.
МЕЖДУ «ЦИВИЛИЗАЦИЕЙ» И«ВАРВАРСТВОМ»: В ПОИСКАХ РИМСКО-ИТАЛИЙСКОЙ ИДЕНТИЧНОСТИ
Authors: В.А. КВАШНИН 
Published: November 2024

Статья посвящена проблеме культурного влияния греческих полисов Южной Италии на Рим. Одним из проявлений этого было проникновение комплекса идей и мифологем греческого происхождения, призванных обосновать родство различных народов Италии с эллинским миром. Италийские общины восприняли и адаптировали идеологические модели, созданные в Афинах в VIV вв. до н.э. Следствием этого было возникновение определенных идеологических ориентиров, объяснявших успехи племен Центральной Италии их приверженностью к более простому и умеренному образу жизни. Возникновение тенденции к конструированию греческого происхождения народов Италии было связано со стремлением самых разных полисов и этнических групп к подобной самоидентификации в свете славы имперского успеха, сформировавшейся после Восточного похода Александра Македонского на базе афинских идеологических разработок.
The article is devoted to the problem of cultural influence of the Greek policies of Southern Italy on Rome. One of the manifestations of this process is the assimilation of a complex of ideas and myths of Greek origin, designed to form the relationship of different peoples of Italy with the Hellenistic world. The Italian community embraced and adapted the ideological models created in Athens in the VIV centuries B.C. The result was the creation of some ideological concepts explaining the success of the tribes of Central Italy by their commitment to a simple and moderate lifestyle. The emergence of the trend towards the construction of the Greek origin of the peoples of Italy was associated with the desire of a variety of policies and ethnic groups to such the selfidentification in the light of the glory of the imperial success, formed after the Eastern campaign of Alexander the Great on the basis of Athenian ideological concepts.
ЭЛЕМЕНТЫ ЛАТЕНТНОГОВАРВАРСТВА В ЭЛЛИНСКОЙКУЛЬТОВОЙ ПРАКТИКЕ
Authors: Л.Г. ШЕПКО 
Published: November 2024

Статья посвящена элементам культовой практики греков, которые наиболее ярко проявляются в массовых общественных действах праздниках и присутствуют в погребальнопоминальных сценариях. Праздники и погребальные церемонии представителей варварского мира (скифов, тюрок) включают такие же элементы. Анализируя эллинский и варварский миры в синхронном контексте, общность обрядов и культовой практики их представителей обычно рассматривают в рамках взаимодействия и заимствования. Сценарии социально значимых мероприятий опираются на мировоззренческую основу общиннородового строя. Выработанный алгоритм коллективных действий сохраняется достаточно долго. Цивилизация привносит разнообразие формы, но в полной мере не может скрыть стадиально варварский компонент на цивилизационном этапе эволюции эллинов.
The article depicts the elements of the Greek cult practices. Processions, initiations, sacrifices, cleansing, competitions, etc. are most vividly manifested in mass public events holidays. They are also present in the ancient Greek funeral / memorial scenarios. Holidays and funeral ceremonies of the barbarian world representatives (Scythians, Turks) include the same elements which may, however, differ in their sequence. Analyzing the Hellenic and Barbaric worlds in a synchronous context, scholars usually think the commonality of rituals and the cult practices of their representatives to be in the framework of interaction and borrowing. At the same time, the formation of scenarios for socially significant events is based on the ideological basis of the communalclan system. Thus, the algorithm of collective actions develops, maintaining itself for a long time. Civilization introduces variety of forms but cannot fully conceal the barbaric stage component at the new civilization level of the Hellenic evolution.
ЛАТЕНТНОЕ ВАРВАРСТВОМЕЖДУ ВАРВАРСТВОМ ИЦИВИЛИЗАЦИЕЙ
Authors: М.Г. ГУСАКОВ 
Published: November 2024

Статья посвящена латентному варварству в поздней Римской империи. Латпнтное варварство, т.е. скрываемое или скрытое варварство, понимается как варварство в олеждах цивилизации. Солдат римской армии, варвар по происхождению, сохраняя полностью или частично менталитет варвара, осваивал латынь, элементы римской культуры, прннимал нормы жизнедеятельности цивилизованного общества. Его притягивали возможности и желание воспользоваться плодами чужой цивилизации. Помимо армии для варваров дорогой в цивилизацию было рабство. Объективно раб имел возможность стать вольным человеком и даже войти в число обеспеченных, а в ряде случаев и богатых людей, скрыто, не всегда разделяя при этом ценности и нормы цивилизации. По мере увеличения числа подобных латентных варваров возрастали конфликты между ними и гражданами Рима. В итоге бывшие варвары, войдя в Рим, постепенно разрушали его, что привело к глубокому кризису всей системы.
The article is devoted to the problem of the latent barbarism in the Late Roman empire. Latent barbarism, i.e. hidden or disguised barbarism, is understood as barbarism wearing civilized clothes. The soldiers of the Roman army, barbarian by origin, keeping all or part of the mentality of the barbarian, mastered the Latin and the elements of Roman culture, accepted primal norms of life of a civilized society. He was attracted by the opportunities and the desire to take advantage of the fruits of alien civilization. In addition to the army for the barbarians the way to civilization was slavery. Objectively, the slave had the opportunity to become a free man and even enter the number of wealthy, and in some cases rich people, not always secretly sharing the values and norms of civilization. As the number of such latent barbarians increased, conflicts between them and the citizens of Rome increased. In the end, the former barbarians, entering Rome, gradually destroyed it, which led to a deep crisis of the whole system.
Политические и географические границы Южного Кавказа (Закавказья)
Authors: А.К. Шагинян 
Published: November 2024

В настоящем исследовании на основании сведений из литературных памятников античной и раннесредневековой географии, а также многочисленных статей из ведущих справочных изданий мира XIXXX вв. представлены и проанализированы термины, касающиеся исторической географии Южного Кавказа (Закавказья) и смежных областей Армянского нагорья. Автор критикует устоявшееся в отечественной литературе, официальной документации и СМИ мнение о южных границах Южного Кавказа (Закавказья). Он показывает, что политические границы Южного Кавказа (Закавказья) на юге значительно шире географических границ, охватывая северо-восточные регионы обширной физико-географической области Армянское нагорье, которые в первой трети XIX в. были включены в состав Российской империи, а после оказались в составе Советского Союза.
In the paper, based on information from the literary sources of ancient and early medieval geography, as well as numerous articles from leading reference books of the world of the 19th20th centuries, the terms applied to the historical geography of the South Caucasus (Transcaucasia) and adjacent areas of the Armenian Highlands are presented and analyzed. The opinion on the southern borders of the South Caucasus (Transcaucasia), which has been established in Russian literature, official documentation and the media is criticized. The author shows that the political borders of the South Caucasus (Transcaucasia) in the south are much wider than geographical borders, covering the northeastern regions of the vast physical and geographical area of the Armenian Highlands, which were included in the Russian Empire in the first third of the 19th century, and later became part of the Soviet Union.
ئیستاتیکای فرەجۆریی دەقئاوێزان لە شیعرەکانی صافی هیرانی دا
Authors: Naz Ahmad Saeed  , Avin Asos Hama  
Published: November 2024

پوخته
گەشەو ئیستاتیکای ئەدەبی، لە هەندێ بارودۆخدا پەیوەستە بە پەیوەندییە ناوخۆییەكان. دەقئاوێزان، وەك میتۆد و ڕێبازێكی ڕەخنەیی، یارمەتیدەرێكی وزەبەخشی ئەرێنیە بۆ دەرخستنی فۆرمی ئەم گەشە و ئیستاتیکایە، جگە لەوەی یەکێک لە تایبەتمەندییەکانی دەقی ئەدەبی ئەوەیە کەوا هەر دەقێک دەشێت لە پەیوەندییەکی کارتێکردندا بێت لەگەڵ دەقەکانی پێش خۆی، ئەمەش وەک دیاردەیەکی ئەدەبی بەرچاودەکەوێت، کەوا لەژێر ڕۆشنایی دەقئاوێزاندا خۆی بەرجەستە دەکات. بەم پێیە ئەم توێژینەوەیە هەوڵێکە بۆ دەرخستنی ئەو سیما ئیستاتیکیانەی لە ئەنجامی فرەجۆریی دەقئاوێزان لە شیعرەکانی صافیدا بەرچاودەکەون.
دەقئاوێزان وەک دیاردەیەکی ئەدەبی، پەیوەستە بە ڕادەی کاریگەری و کارتێکردنی شاعیران لەگەڵ یەکتری، لەبەرئەوە صافی هیرانی وەک شاعیرێکی کلاسیک لە ژێر کاریگەری شاعیرانی کلاسیکدابووە و لە هەمانکاتیشدا هۆشیاری و باڵادەستی شاعیر بەسەر دیاردە ئەدەبی و کلتورییەکان و ڕۆشنبیرییەکانی قۆناغەکەی، ئەنجامی ئەو کاریگەرییە پیشاندەدات. لەبەر ڕۆشنایی ئەم کاریگەرییەدا توێژینەوەکەمان ئەو ڕەهەندە ئیستاتیکییانەی دەرخستووە کەوا فرەجۆریی دەقئاوێزان لە دەقە شیعرییەکانی شاعیردا دەردەخەن، هەروەک؛ دەرخستنی ئەو دیاردە دەقئاوێزانیانەی لە ئەنجامی کاریگەری شاعیرانی کلاسیک لەلایەک و لەلایەکی تریش ئەو ڕەهەندانەی دەقئاوێزانی کلتوری وئاینی ڕۆشنبیری و فۆلکلۆری دەردەخەن.
Performance and mechanism of ‘coagulation co-adsorption’ on simultaneous reduction of turbidity and low-fluoride pollution by a polymer metal-based defluorination and turbidity-removal agent (PMDTA)
Authors: Fu Ying , Zheng Jiewen , Li Junhui , Wang Jie , Cheng Ming , Hang Qixin 
Published: November 2024

ABSTRACT

A polymer metal-based defluorination and turbidity-removal agent (PMDTA) was prepared using a poly-Si–Fe coagulant (PSF) and aluminum. Simultaneous reduction of turbidity and fluoride by PMDTA was studied using the ‘coagulation co-adsorption (CcA)’ method for the simulated and real low-fluoride waters, respectively, compared with that by PSF. The surface and bond structures, charged properties, and size of PMDTA and its flocs were explored, and the mechanism of removing turbidity and fluoride was analyzed. The results showed PMDTA decreased fluoride to &lt;1 mg/L (PSF could not), but both decreased turbidity to &lt;0.5 NTU. PMDTA adapted to a wider initial turbidity, humid acid (HA), NaCl, and temperature. PMDTA had similar bond structures to PSF, more complex surface structures than PSF, and higher surface space and adsorption sites than PSF. Filtration had almost no impact on fluoride removal, but gave positive impact on turbidity removal. The removal mechanisms of fluoride and turbidity were different: the former was mainly removed through adsorption on PMDTA-flocs (controlled by their forming conditions) having efficient adsorption properties, and the latter was mainly cleared through a synergistic effect of the Derjaguin–Landau–Verwey–Overbeek (DLVO) theory (classic coagulation mechanism). The efficient fluoride removal by PMDTA can fully utilize the existing facilities in water plants.
Evaluation of the Effects of Guizhi Shaoyao Zhimu Decoction on Rheumatoid Arthritis by Ultrasound Combined with Electrophysiological Examination
Authors: Shi Miao , Li Xin , Yuan Min , Chen Feng , Xu Lishan , Pan Xiaojie , Lv Baowei , Teng Jianbo 
Published: November 2024

Background:
Guizhi Shaoyao Zhimu Decoction can be used in the treatment of rheumatoid arthritis, but there is scarce literature on using ultrasound combined
with electrophysiology to evaluate the efficacy of this traditional Chinese medicine.

Aim:
This study aimed to explore the clinical effect of Guizhi Shaoyao Zhimu decoction on cold-dampness arthralgia rheumatoid arthritis (RA) by
ultrasound and electrophysiological examination.

Methods:
A total of 64 patients with rheumatoid arthritis were randomly divided into two groups, with 32 cases in each group. The control group was treated
with conventional western medicine, and the experimental group was treated with Guizhi Shaoyao Zhimu Decoction in addition to conventional
western medicine. After 4 weeks of treatment, traditional Chinese medicine (TCM) symptom scores, erythrocyte sedimentation rate (ESR), Creactive
protein (CRP), 28 joint disease range of motion score (DAS28), ultrasonic score, and electrophysiological examination results were
observed.

Results:
There were significant differences in TCM syndrome scores, ESR, CRP, DAS28, and ultrasound scores in the two groups before and after
treatment (P<0.05). Compared between the two groups after treatment, there were statistically significant differences in TCM syndrome scores,
ESR, CRP, DAS28, and ultrasound scores (P<0.05). The motor nerve conduction velocity (MNCV), sensory nerve conduction velocity (SNCV),
and action potential (AP) of the median nerve and ulnar nerve in the experimental group were significantly increased compared with the control
group (P<0.05).

Conclusions:
Guizhi Shaoyao Zhimu Decoction combined with conventional western medicine has a significant effect on cold-dampness arthralgia rheumatoid
arthritis, and ultrasound and electrophysiological examination can be used to evaluate its curative effect.
Upregulation of LncRNA WT1-AS Inhibits Tumor Growth and Promotes Autophagy in Gastric Cancer via Suppression of PI3K/Akt/mTOR Pathway
Authors: Zhang Xiaobei , Jin Meng , Yao Xiaoying , Liu Jilan , Yang Yonghong , Huang Jian , Jin Guiyuan , Liu Shiqi , Zhang Baogui 
Published: November 2024

Background:
Increasing evidence has highlighted the involvement of the imbalance of long non-coding RNAs in the development of gastric cancer (GC), which
is one of the most common malignancies in the world. This study aimed to determine the role of lncRNA WT1-AS in the progression of GC and
explore its underlying mechanism.

Methods:
The expression of lncRNA WT1-AS in gastric cancer tissues was detected using RT-qPCR. We knocked down the expression of WT1-AS in GC
cells or treated them with rapamycin or both. Then, transwell assay and scratch assay were carried out to determine the migration of GC cells, and
flow cytometry was carried out to determine the cell cycle. The immunofluorescence technique was used to determine the autophagy, and a tumor
formation experiment was carried out to determine tumor growth in vivo. The expression of factors related to the PI3K/Akt/mTOR pathway was
also measured by Western Blotting.

Results:
In GC tissues and cells, lncRNA WT1-AS was underexpressed. Moreover, overexpression of lncRNA WT1-AS blocked the PI3K/Akt/mTOR
pathway. Upregulation of lncRNA WT1-AS or inhibition of the PI3K/Akt/mTOR pathway suppressed cancer cell migration in vitro, leading to cell
cycle arrest, and promoted autophagy while inhibiting tumor growth in vivo. It also reduced the expression levels of Ki-67, MMP2, MMP9, and
VEGF. The WT1-AS+rapamycin group was the most prominent in all experiments.

Conclusion:
The upregulation of lncRNA WT1-AS could suppress the PI3K/Akt/mTOR pathway, which inhibits cell migration and cell cycle arrest while
promoting autophagy in gastric cancer cells.