bluuebunny/crossref_metadata_2025_split huggingface dataset:
What is Important in E-health Interventions for Stroke Rehabilitation? A Survey Study among Patients, Informal Caregivers, and Health Professionals.
Authors: Wentink Manon M. , Bodegom-Vos Leti van , Brouns Berber , Arwert Henk J. , Vliet Vlieland Thea P.M. , De Kloet Arend J. , Meesters Jorit J. L. 
Published: August 2018

Incorporating user requirements in the design of e-rehabilitation interventions facilitates their implementation. However, insight into requirements for e-rehabilitation after stroke is lacking. This study investigated which user requirements for stroke e-rehabilitation are important to stroke patients, informal caregivers, and health professionals. The methodology consisted of a survey study amongst stroke patients, informal caregivers, and health professionals (physicians, physical therapists and occupational therapists). The survey consisted of statements about requirements regarding accessibility, usability and content of a comprehensive stroke e-health intervention (4-point Likert scale, 1=unimportant/4=important). The mean with standard deviation was the metric used to determine the importance of requirements. Patients (N=125), informal caregivers (N=43), and health professionals (N=105) completed the survey. The mean score of user requirements regarding accessibility, usability and content for stroke e-rehabilitation was 3.1 for patients, 3.4 for informal caregivers and 3.4 for health professionals. Data showed that a large number of user requirements are important and should be incorporated into the design of stroke e-rehabilitation to facilitate their implementation.
Safety and Feasibility of a First-Person View, Full-Body Interaction Game for Telerehabilitation Post-Stroke
Authors: Proffitt Rachel , Warren Jessica , Lange Belinda , Chang Chien-Yen 
Published: August 2018

This study explored the feasibility and safety of pairing the Microsoft Kinect® sensor with the Oculus Rift® Head Mounted Display (HMD) as a telerehabilitation technology platform for persons post-stroke. To test initial safety, fourteen participants without disabilities (age 30 ± 8.8 years) engaged in a game-based task using the Microsoft Kinect® with a first-person view using the Oculus Rift®. These tasks were repeated for five participants post-stroke (age 56 ± 3.0 years). No significant adverse events occurred in either study population. When using the Oculus Rift® HMD, three participants without disabilities reported dizziness and nausea. All of the participants post-stroke required hands-on assistance for balance and fall prevention. The intensive nature of physical support necessary for this type of interaction limits the application as a telerehabilitation intervention. Given the increasing availability of HMDs for commercial use, it is crucial that the safety of immersive games and technologies for telerehabilitation is fully explored.
CHEROKEE ARCHAEOLOGICAL LANDSCAPES AS COMMUNITY ACTION
Authors: Sampeck Kathryn , Griffin Jr Johi D. 
Published: August 2018

Um programa de pesquisa e educação atualmente desenvolvido pelos próprios autores e outros membros do Tribal Historic Preservation Office of the Eastern Band of Cherokee Indians contribui diretamente para o desenvolvimento econômico, para a educação, e para a criação de identidades e comunidades. De fato, a arqueologia da paisagem revela como os Cherokees atravessaram o fundamental e tumultuado período entre o século dezesseis e o inicio do século dezoito, um passado silenciado nos programas de educação atuais e nos livros de história. Do ponto de vista Cherokee, as nossas origens são ligadas aos princípios de gadugi, traduzido por ‘cidade’ ou ‘comunidade,’ e tohi, ‘equilibro.’ Gadugi e tohi juntos são os pilares da identidade Cherokee. Estes princípios aparentemente abstratos são arqueologicamente perceptíveis: gadugi se entende claramente pelo estudo das relações espaciais da organização interna da comunidade, a rede de relações entre cidades e recursos regionais, artefatos e ecofatos ligados às atividades, e elementos de grande escala “não sítios”, como os caminhos e os campos agrícolas. Nossa pesquisa está concentrada sobre um tempo histórico essencial ainda que pouco estudado: os encontros coloniais do século dezesseis até o inicio do século dezoito. A arqueologia tem um papel capital em termos de justiça social e ética da gestão da paisagem cultural, fornecendo às Primeiras Nações um acesso equipável aos benefícios potenciais de paisagens culturais assim como à uma participação significativa nos planos e ações a respeito deles.
Integrating Unmanned Aircraft Systems to Measure Linear and Areal Features into Undergraduate Forestry Education
Authors: Viegut Reid , Kulhavy David L. , Unger Daniel R , Hung I-Kuai , Humphreys Brian 
Published: August 2018

The use of Unmanned Aircraft Systems (UAS) in undergraduate forestry education continues to expand and develop. Accuracy of data collection is an important aspect of preparation for “society-ready” foresters to meet the complex sustainable environment managing for ecological, social and economic interests. Hands-on use of a DJI Phantom 4 Pro UAS by undergraduates to measure the length and area of 30 linear features and areal features on Earth’s surface were estimated. These measurements were compared (measured within the ArcMap 10.5.2 interface) to hyperspectral Pictometry imagery measured on the web-based interface and the Google Earth Pro interface. Each remotely estimated measurement was verified with the actual ground measurements and the methods compared. An analysis of variance, conducted on the absolute length errors resulting in a p-value of 0.000057, concluded that the three length estimating techniques were statistically different at a 95% confidence interval. A Tukey pair-wise test found that the remotely sensed DJI Phantom 4 Pro data was statistically less accurate than the Pictometry and Google Earth Pro data, while both of which were found to be not different statistically in terms of accuracy. The areal feature area measurements were not normally distributed and therefore tested for equal medians using a Kruskal-Wallis test. The test found that there was no significant difference between sample medians, indicating that all three methods of estimating area are statistically equal in accuracy. The results indicate that Pictometry and Google Earth Pro could both be used to accurately estimate linear feature lengths remotely in lieu of in situ linear measurements while all three remote sensing techniques can be used to accurately estimate areal feature areas remotely in lieu of in situ areal measurements.
Student Produced Videos - An Innovative and Creative Approach to Assessment
Authors: Speed Caroline Jane , Lucarelli Giuseppe Andrea , Macaulay Janet Olwyn 
Published: August 2018

The ability to think critically and creatively are essential graduate attributes for science students yet many science graduates lack these skills and may struggle to gain employment. As undergraduate science educators, we are aiming to improve critical thinking, creativity and the promotion of deeper learning in our students. We have designed and implemented an innovative and creative approach to assessment to engage students with laboratory practicals, which are a core component of the biomedical sciences at Monash University. Through the introduction of an innovative approach to assessment using small group student produced videos, we aim to improve skills in theoretical understanding, data analysis and presentation.This paper details the design of instructional guidelines for small group student produced video assessment, the implementation of the video assessment into 2nd and 3rd year biochemistry laboratory practical classes and the generation of research outcomes and evaluation of this novel assessment technique. Observation of student behaviour during the laboratory classes found students were filming/photographing their experiments and appeared far more engaged with the actual experiments than in previous years. In addition, many student videos demonstrated high levels of creativity and critical thinking. The student produced video assessment did provide an opportunity for creative and critical thinking in students but there are still aspects to be improved.
Feeding regimen modulates zebrafish behavior
Authors: Dametto Fernanda S. , Fior Débora , Idalencio Renan , Rosa João Gabriel S. , Fagundes Michele , Marqueze Alessandra , Barreto Rodrigo E. , Piato Angelo , Barcellos Leonardo J.G. 
Published: August 2018

Here we show that the feeding regimen modulates zebrafish (Danio rerio) behavior. With regard to the time elapsed between feeding and behavioral evaluation, fish fed 3 h before behavioral evaluation in the novel tank test (NTT) showed decreased activity and a trend toward an anxiolytic reaction (increased use of the upper section of the aquarium) in comparison to fish fed 0.5, 6, 12, 24 or 48 h before testing, although differences were not statistically significant for all comparisons. Activity and use of the upper section of the aquarium did not differ significantly among the other treatments. Regarding feeding frequency, fish fed once a day showed higher anxiety-like behavior (decreased use of the upper section of the aquarium) in comparison to fish fed twice a day, but feeding four or six times per day or only every second day did not result in differences from feeding twice a day. Feeding frequency had no effect on activity level. Metabolically, fish fed once a day presented decreased levels of glucose and glycogen and increased lactate when compared to the regular feeding (fish fed twice a day), suggesting that feeding regimen may modulate carbohydrate metabolism. Mechanistically, we suggest that the metabolic changes caused by the feeding regimen may induce behavioral changes. Our results suggest that the high variability of the results among different laboratories might be related to different feeding protocols. Therefore, if issues pertaining to the feeding regimen are not considered during experiments with zebrafish, erroneous interpretations of datasets may occur.
Patterns in evolutionary origins of heme, chlorophyll a and isopentenyl diphosphate biosynthetic pathways suggest non-photosynthetic periods prior to plastid replacements in dinoflagellates
Authors: Matsuo Eriko , Inagaki Yuji 
Published: August 2018

Background
The ancestral dinoflagellate most likely established a peridinin-containing plastid, which have been inherited in the extant photosynthetic descendants. However, kareniacean dinoflagellates and Lepidodinium species were known to bear “non-canonical” plastids lacking peridinin, which were established through haptophyte and green algal endosymbioses, respectively. For plastid function and maintenance, the aforementioned dinoflagellates were known to use nucleus-encoded proteins vertically inherited from the ancestral dinoflagellates (vertically inherited- or VI-type), and those acquired from non-dinoflagellate organisms (including the endosymbiont). These observations indicated that the proteomes of the non-canonical plastids derived from a haptophyte and a green alga were modified by “exogenous” genes acquired from non-dinoflagellate organisms. However, there was no systematic evaluation addressing how “exogenous” genes reshaped individual metabolic pathways localized in a non-canonical plastid.

Results
In this study, we surveyed transcriptomic data from two kareniacean species (Karenia brevis and Karlodinium veneficum) and Lepidodinium chlorophorum, and identified proteins involved in three plastid metabolic pathways synthesizing chlorophyll a (Chl a), heme and isoprene. The origins of the individual proteins of our interest were investigated, and we assessed how the three pathways were modified before and after the algal endosymbioses, which gave rise to the current non-canonical plastids. We observed a clear difference in the contribution of VI-type proteins across the three pathways. In both Karenia/Karlodinium and Lepidodinium, we observed a substantial contribution of VI-type proteins to the isoprene and heme biosynthesises. In sharp contrast, VI-type protein was barely detected in the Chl a biosynthesis in the three dinoflagellates.

Discussion
Pioneering works hypothesized that the ancestral kareniacean species had lost the photosynthetic activity prior to haptophyte endosymbiosis. The absence of VI-type proteins in the Chl a biosynthetic pathway in Karenia or Karlodinium is in good agreement with the putative non-photosynthetic nature proposed for their ancestor. The dominance of proteins with haptophyte origin in the Karenia/Karlodinium pathway suggests that their ancestor rebuilt the particular pathway by genes acquired from the endosymbiont. Likewise, we here propose that the ancestral Lepidodinium likely experienced a non-photosynthetic period and discarded the entire Chl a biosynthetic pathway prior to the green algal endosymbiosis. Nevertheless, Lepidodinium rebuilt the pathway by genes transferred from phylogenetically diverse organisms, rather than the green algal endosymbiont. We explore the reasons why green algal genes were barely utilized to reconstruct the Lepidodinium pathway.
Usefulness of miRNA-338-3p in the diagnosis of pemphigus and its correlation with disease severity
Authors: Lin Naiyu , Liu Qingxiu , Wang Menglei , Wang Qian , Zeng Kang 
Published: August 2018

Background
Pemphigus is a common life-threatening, autoimmune bullous disease effecting both cutaneous and mucous membranes. Previous diagnosis of pemphigus is based on clinical presentations, histopathology, immunofluorescence and enzyme-linked immunosorbent assay. Furthermore, no laboratory parameters could be used to indicate disease severity. MicroRNAs are endogenous small RNAs, which could be used as diagnostic biomarkers for some autoimmune diseases. Previously, miR-338-3p has been proven significantly up-regulated in pemphigus patients.

Methods
Pemphigus patients (including pemphigus vulgaris and pemphigus foliaceus) with active lesions and with remission, patients diagnosed as bullous pemphigoid and healthy volunteers were recruited, and miR-338-3p expression level was measured using reverse transcriptase-quantitative polymerase chain reaction (RT-qPCR). Active pemphigus patients accepting treatment were followed up for at least 2 weeks to investigate the expression change of miR-338-3p during treatment period. Target genes of miR-338-3p were screened through computer-aided algorithm and verified by RT-qPCR, Western blot and Luciferase activity assay.

Results
MiR-338-3p was specifically increased in patients diagnosed as pemphigus with active lesions. The expression level of miR-338-3p gradually decreased after effective treatment. MiR-338-3p expression was independently correlated with disease severity defined by PDAI (Pemphigus Disease Area Index) or ABSIS (Autoimmune Bullous Skin Disorder Intensity Score) criteria. Up-regulation of miR-338-3p could significantly suppress RNF114 expression at mRNA and protein level in vitro.

Discussion
MiR-338-3p could be used as a diagnostic biomarker of pemphigus in addition to other traditional methods. Up-regulation of MiR-338-3p was associated with more severe condition in pemphigus. RNF114 is the target gene of miR-338-3p, which probably participates in the regulation of disease activity of pemphigus.
CD80 and CTLA-4 as diagnostic and prognostic markers in adult-onset minimal change disease: a retrospective study
Authors: Zhao Bing , Han Hui , Zhen Junhui , Yang Xiaowei , Shang Jin , Xu Liang , Wang Rong 
Published: August 2018

Background
Minimal change disease (MCD) is a form of idiopathic nephrotic syndrome. Compared to children, adult-onset MCD patients are reported to have delayed responses to glucocorticoid treatment. Several studies of children have suggested detecting urinary CD80 levels to diagnose MCD. There are no effective diagnostic methods to distinguish steroid-sensitive MCD from steroid-resistant MCD unless treatments are used.

Methods
In a total of 55 patients with biopsy-proven MCD and 26 patients with biopsy-proven idiopathic membranous nephropathy, CD80 and cytotoxic T-lymphocyte antigen-4 (CTLA-4) levels in serum, urine and renal tissue were analyzed.

Results
Steroid-sensitive MCD patients in remission had lower urinary CD80 levels and higher CTLA-4 levels than patients in relapse (156.65 ± 24.62 vs 1066.40 ± 176.76 ng/g creatinine; p < 0.0001), (728.73 ± 89.93 vs 151.70 ± 27.01 ng/g creatinine; p < 0.0001). For MCD patients in relapse, mean urinary CD80 level was higher, and CTLA-4 level was lower for those who were steroid-sensitive than those who were steroid-resistant (1066.40 ± 176.76 vs. 203.78 ± 30.65 ng/g creatinine; p < 0.0001), but the mean urinary CTLA-4 level was lower (151.70 ± 27.01 vs. 457.83 ± 99.45 ng/g creatinine; p < 0.0001). CD80 expression in glomeruli was a sensitive marker to diagnose MCD. The absent or minimal expression of CTLA-4 in glomeruli could distinguish steroid-sensitive MCD from steroid-resistant MCD.

Conclusions
Glucocorticoid treatment may result in complete remission for only MCD patients with strongly positive CD80 expression and negative CTLA-4 expression in glomeruli, or higher urinary CD80 level and lower CTLA-4 level.
Implementation of Republic Act 9593 (National Tourist Act) as Perceived by the Selected Residents of Dipolog City, Philippines
Authors: Batara Abraham , Flora Chrymae 
Published: August 2018

Tourism has provided some essential benefits to the local community as an economic development tool which paved the way for employment and investment, cultural attraction, festivals and outdoor reaction opportunities (Anderek & Vogt, 2000). The study was conducted to assess the implementation of Republic Act 9593 (National Tourist Act) as perceived by the selected residents of Dipolog City. Specifically, it determined: 1) the awareness of the residents of Dipolog City on the implementation of RA 9593; 2) the roles of the LGUs of Dipolog City on the implementation of RA 9593; and 3) the perceptions of the residents of Dipolog City on the effects of implementation of RA 9593 in terms of benefits and satisfaction. There are 100 respondents of this study from the five communities of Dipolog with 6 key informant officials. Frequency and percentage were used in the presentation and analysis of data collected through survey and interviews with key informants. Using descriptive method, results revealed that by implementing the policy of Tourism Act of 2009 in Dipolog, positive effects on the city economic, social and environmental development occurred. The awareness of the residents contributed successful implementation of Tourism Act of 2009, by formulating their own policies in the form of ordinances, resolutions, plans and programs of LGU units.
Educational Broadcast Programs Tuned In: Tool for Enhancing Learning in Educational Broadcasting to Residents of Canipaan, Leyte, Philippines
Authors: Ugsad Rothelia Maria , Entoma Susan , Laureno Henry Mar 
Published: August 2018

Educational broadcasting serves as a way to enrich learning. It features programs which aim to reinforce learning and are usually entertaining as well as educational. The study aimed to investigate the needs of the Institute's adopted local community - Canipaan residents in enhancing learning particularly on livelihood projects through educational broadcast programs. Supported by an interview, this descriptive study was conducted to the residents from the aforementioned institute's adopted community using percentage equivalent and Pearson r as statistical tools. On relationship between profiles and media resources and its program stations, most of the residents' profiles such as age, sex, educational attainment, family income and membership in organizations were significantly associated with broadcast resources at 0.01 levels. They were as well associated strongly with TV stations. Meanwhile, regarding the media programs tuned in by these residents through radio and television broadcast firms, majority of them had nothing to tune in as they had no media resources. However, if they would be informed how it would be necessary to be updated especially on current news, health tips and livelihood programs, they would probably switch their interest in listening to educational programs to help improve their lifestyles. Respondents, in general, indicated that they looked forward to an establishment of a community radio station to be able to reach out to their needs.
Contextualizing Human Resource Management Practices: The Philippine Experience for an HEI
Authors: Cabahug Monriud , Ferrater-Gimena Judy Ann 
Published: August 2018

Human resource management is extremely imperative for any association, particularly in the scholarly setting. The employees should be given a clear direction on where they are going to when they become part of the organization. This study aimed to assess the extent of the manifestation of a sound human resource management (HRM) practices of the University of Cebu-Banilad as assessed by the teaching and the non-teaching staff. The results of this investigation will be used as basis for the formulation of interventions in the current human resource management system. This study utilized the predictive relational method of research using a researcher-made questionnaire. Using purposive sampling, there were forty-seven (47) employees who participated in this investigation. Percent, median, mode, and range were computed to analyze the data. The results revealed that wage and salary, administration, training and development, and change in personnel status were practiced in some cases only. Further, career management, job security and status, working condition, and people empowerment were the factors that motivate them in some cases to perform well in their respective job functions. There is a significant relationship between the age and the respondents' perception of the human resource management practices. However, there was no connection between the sexual orientation of the representatives and their reactions to the motivational variables.
Division of Lanao Del Sur 1, DepEd-ARMM: Its Vital Role in Peacebuilding and Reconciliation in the Post-Conflict Settings
Authors: Sumagayan Sahanee 
Published: August 2018

The Philippines has experienced over 40 years of internal armed conflict in the Southern Island of Mindanao, as the resident Muslim population continues to demand self-determination. Hence, this study aimed to locate and explore frameworks on building peace initiatives and conflict tools resolution as the symbolic rites of procedures. Specifically, it sought to: 1) Understand the meaning of peacebuilding and reconciliation in the context of post-conflict settings; 2) Define extremism; 3) Determine the role of Division of Lanao del Sur 1, DepEd-ARMM in preventing extremism, and 4) Determine how education can counter religious extremism. Using documentary analysis method, data were obtained and collected from the Mindanao State University (MSU) System library, the Armed Forces of the Philippines, the Philippine National Police, the Department of Education (DepEd-ARMM), the Department of Social Welfare and Development (DSWD), the Philippine National Red Cross (PNRC), and Bangon Marawi Task Force. There were six (6) key informants interviewed by the researcher. Based on the nature of the study, no statistical treatment of data gathered was done. This is the limitation of the study. Findings revealed that peacebuilding facilitates the establishment of durable peace and prevents the recurrence of violence through reconciliation, education, institutional and political building for economic transformation. The Division of Lanao del Sur 1, DepED-ARMM recommends that the government should create an independent commission to highlight measurable progress and determine the benchmarks that these programs have met.