bluuebunny/crossref_metadata_2025_split huggingface dataset:
Implementasi Metode Inquiry untuk Meningkatkan Motivasi dan Prestasi Belajar Fiqh Siswa di Kelas VIII MTs Nurul Iman NW Keruak Tahun Pembelajaran 2016/2017
Authors: Efendi Saprudin 
Published: August 2019

Di era globalisasi sekarang pendidikan dihadapkan pada tuntutan yang semakin meningkat, baik mutu, maupun kualitasnya. Untuk itu kreativitas seorang guru sangat diperlukan agar tercipta suasana pembelajaran yang lebih menyenangkan. Sesuai hasil evaluasi kurikulum KTSP (2007), diketahui bahwa siswa MTs Nurul Iman NW Keruak belum mencapai kemampuan optimalnya. Siswa hanya tahu banyak fakta tetapi kurang mampu memanfaatkannya, oleh sebab itu sistem pendidikan saat ini dan di masa depan harus dikembangkan agar lebih responsif terhadap tuntutan masyarakat dan tantangan yang akan dihadapi. Hasil penelitian menunjukkan; Metode Inquiry dapat meningkatkan motivasi belajar Fiqih siswa. Hal ini terlihat dari prosentase peningkatan motivasi belajar Fiqih siswa sebesar 28.44% pada data awal (sebelum diterapkan Metode Inquiry) sebesar 49.26%, dan meningkat pada siklus I sebesar 77.70%, serta pada siklus II motivasi belajar siswa sebesar 80.71% atau meningkat 31.45% dari data awal serta meningkat 3.01% dari siklus I. Dengan rata-rata prosentase nilai motivasi belajar Fiqih siswa antara siklus I dan siklus II sebesar 79.20%
DigestiFlow - reproducible demultiplexing for the single cell era
Authors: Holtgrewe Manuel , Nieminen Mikko , Messerschmidt Clemens , Beule Dieter 
Published: August 2019

Summary. Managing raw sequencing data and conversion into sequences (demultiplexing) remains a challenging topic for groups running sequencing devices. They face many challenges in such efforts and solutions range from manual management of spreadsheets to very complex and customized LIMS systems handling much more than just sequencing raw data. In this manuscript, we describe the software package DigestiFlow that focuses on the management of Illumina flow cell sample sheets and raw data. Namely, it allows for automated extraction of flow cell raw data information, management of sample sheets, and the automated (and thus reproducible) demultiplexing of Illumina base calls data.
Availability and Implementation. The software is available under the MIT license at https://github.com/bihealth/digestiflow-server. The client and demux software components are available via Bioconda.
Developing a global occupational health and safety management system model for Japanese companies
Authors: Kajiki Shigeyuki , Mori Koji , Kobayashi Yuichi , Hiraoka Kou , Fukai Nanae , Uehara Masamichi , Adi Nuri Purwito , Nakanishi Shigemoto 
Published: August 2019

Abstract

Objectives
To develop and validate a global occupational health and safety management system (OHSMS) model for Japanese companies.

Methods
In cooperation with a Japanese company, we established a research team and gathered information on occupational health and safety (OHS) practices in nine countries where the target company operated manufacturing sites. We then developed a model hypothesis via research team meeting. The model hypothesis was introduced to local factories in Indonesia and Thailand as trial sites. We evaluated the roles of the company headquarters, the implementation process, and any improvements in OHS practices at the sites. Based on the results, a global OHSMS model was formalized for global introduction.

Results
The model consisted of both headquarters and site roles. These roles were well-functioning, and OHS at the sites improved. Two issues concerning the functioning of the headquarters were identified: the need to establish a reporting system to the headquarters and the need to support the improvement of specialized human resources. By improving the model hypothesis to address these issues, the model was formalized for global introduction.

Conclusions
The global OHSMS model was based on the use of methods and specialized human resources relevant to each region and their common objectives, as well as evaluation indicators based on the minimum requirements of the company headquarters. To verify the effectiveness of this model, the experiment should be extended to other countries.
Safety and Tolerability of Thrombin Inhibition in Scleroderma‐Associated Interstitial Lung Disease
Authors: Silver R. M. , Wilson D. A. , Akter T. , Atanelishvili I. , Huggins J. T. , Kajdasz K. , Highland K. B. , Nietert P. J. , Bogatkevich G. S. 
Published: August 2019

ObjectiveInterstitial lung disease (ILD) is a frequent complication of systemic sclerosis (SSc) (scleroderma) and the leading cause of scleroderma‐related deaths. There exists an unmet need for a new drug therapy for ILD‐complicated SSc. Substantial evidence supports an important role for thrombin in the pathogenesis of SSc‐associated ILD (hereafter SSc‐ILD), and targeting thrombin with a direct thrombin inhibitor could prove to be a novel and effective treatment strategy. As a first step toward designing a clinical trial to test the efficacy of thrombin inhibition in SSc‐ILD, we conducted this study to test the safety and tolerability of dabigatran in patients with SSc‐ILD.MethodsWe performed a prospective, single‐center, open‐label treatment trial with the direct thrombin inhibitor, dabigatran, in patients with SSc‐ILD. Any patient with a history of gastrointestinal hemorrhage or gastric antral vascular ectasia was excluded. Blood monitoring was performed monthly, and patient‐reported outcomes, pulmonary function tests, and skin scores were obtained at baseline and at 3‐ and 6‐month visits. Bronchoscopy with bronchoalveolar lavage (BAL) was performed at baseline and at 6 months for measurement of lung thrombin activity.ResultsOf 15 patients with SSc‐ILD, 14 completed 6 months of treatment with dabigatran at 75 mg taken orally twice daily. Adverse events were uncommon and usually mild or unrelated to the study medication. No serious adverse event was observed. Dabigatran was well tolerated, and we observed no significant gastrointestinal, pulmonary, or other safety issues or intolerability. BAL fluid thrombin activity decreased or remained stable in 13 of 14 (92.8%) subjects.ConclusionDabigatran appears to be safe and well tolerated in patients with SSc‐ILD. A larger randomized controlled trial to test the efficacy of direct thrombin inhibition with dabigatran can be considered.
Upconversion Luminescence Sandwich Assay For Detection of Influenza H7 Subtype
Authors: Tsang Ming‐Kiu , Wong Yuen‐Ting , Tsoi Tik‐Hung , Wong Wing‐Tak , Hao Jianhua 
Published: August 2019

AbstractWith large anti‐Stokes shifts and background‐free signals, upconversion luminescent (UCL) screening assays have been a promising method to reduce the transmission of influenza epidemic, which can critically alleviate the disease burden and extra annual deaths. In this work, a luminescent resonance energy transfer sandwich assay is developed, which utilizes core–shell upconversion nanoparticles and gold nanoparticles as the donor and acceptor, respectively. The influenza H7 gene of H7N9 virus is used as the target for optimization of the assay. Importantly, the hybridization time of the assay is ≈40 min and the specificity test indicates the probes are specific toward the H7 target. The limit of detection of the system is ≈134 × 10−12 m (≈3.22 × 1010 molecules). Moreover, the assay is tested with the use of polymerase chain reaction validated samples from human isolates. The results are promising for implanting future on‐site rapid influenza screening application.
Switching between Crystallization from the Glassy and the Undercooled Liquid Phase in Phase Change Material Ge2Sb2Te5
Authors: Pries Julian , Wei Shuai , Wuttig Matthias , Lucas Pierre 
Published: August 2019

AbstractControlling crystallization kinetics is key to overcome the temperature–time dilemma in phase change materials employed for data storage. While the amorphous phase must be preserved for more than 10 years at slightly above room temperature to ensure data integrity, it has to crystallize on a timescale of several nanoseconds following a moderate temperature increase to near 2/3 Tm to compete with other memory devices such as dynamic random access memory (DRAM). Here, a calorimetric demonstration that this striking variation in kinetics involves crystallization occurring either from the glassy or from the undercooled liquid state is provided. Measurements of crystallization kinetics of Ge2Sb2Te5 with heating rates spanning over six orders of magnitude reveal a fourfold decrease in Kissinger activation energy for crystallization upon the glass transition. This enables rapid crystallization above the glass transition temperature Tg. Moreover, highly unusual for glass‐forming systems, crystallization at conventional heating rates is observed more than 50 °C below Tg, where the atomic mobility should be vanishingly small.
Safe, Metal‐Free, and Direct Synthesis of Dialkyl Acylmethylidenehydrazine‐1,1‐dicarboxylates from Dimethylsulfoxonium Acylmethylides and Dialkyl Azodicarboxylates
Authors: Zhou Bingnan , Dong Jun , Xu Jiaxi 
Published: August 2019

AbstractN‐Acylhydrazones are versatile electrophiles for the synthesis of nitrogen‐containing compounds. Dialkyl acylmethylidenehydrazine‐1,1‐dicarboxylates are a class of N‐acylhydrazones and were prepared efficiently from dimethylsulfoxonium acylmethylides and dialkyl azodicarboxylates. The reaction is temperature‐controlled, generating tetraalkyl 3,6‐diacyl‐1,2,4,5‐tetrazinane‐1,2,4,5‐tetracarboxylates as major products accompanied by dialkyl acylmethylidenehydrazine‐1,1‐dicarboxylates as byproducts at low temperature, or dialkyl acylmethylidenehydrazine‐1,1‐dicarboxylates only at high temperature. The current direct synthetic method is a safe and transition‐metal‐free route for the synthesis of dialkyl acylmethylidenehydrazine‐1,1‐dicarboxylates.magnified image
Value of supplementing vitamin C to the triple therapy on the eradication rates ofHelicobacter pyloriinfection
Authors: El Shahawy Mohamed S. , El Metwaly Ibrahim , Shady Zakarya M. 
Published: August 2019

AbstractSeveral clinical studies have shown that higher prevalence ofHelicobacter pyloriinfection is associated with low vitamin C (Vit C) level in serum. The aim of this study was to assess the effect of supplementation of Vit C on the eradication rates of clarithromycin‐based triple therapy forH. pyloriinfection. This study included 100 patients diagnosed withH. pylorigastritis using magnifying narrow‐band imaging endoscopy supported by stool antigen test. Patients were divided into two groups: Patients in group A (n = 50) received amoxicillin, clarithromycin, and esomeprazole for 2 weeks while patients in group B (n = 50) received Vit C for 4 weeks, in addition to amoxicillin, clarithromycin, and esomeprazole for 2 weeks. The eradication rates were assessed using per‐protocol (PP) and intention‐to‐treat (ITT) analysis. Our results revealed that, eradication was achieved in 31 (70.45%) of 44 patients by PP and 31 (62.%) of 50 by ITT analysis in group A, while in group B, eradication was achieved in 34 (73.91%) of 46 patients by PP and 34 (68%) of 50 by ITT analysis. However, when Vit C supplementation was added to the clarithromycin‐based triple therapy it was observed that there were no statistically significant differences between groups A and B (P= .663 in ITT analysis andP= .727 in PP analysis).Our results demonstrated that supplementing Vit C to clarithromycin‐based triple therapy did not provide an additional advantage for achieving significantly higher eradication rates forH. pylori‐related chronic gastritis and most likely to be preventive rather than curative.
Tunable Hydrogen Release from Amine–Boranes via their Insertion into Functional Polystyrenes
Authors: Ledoux Audrey , Brunet Juliette , Raynaud Jean , Lacôte Emmanuel 
Published: August 2019

AbstractPolystyrene‐g‐boramine random copolymers are dihydrogen reservoirs with tunable dehydrogenation temperatures, which can be adjusted by selecting the boramine content in the copolymers. They display a unique dihydrogen thermal release profile, which is a direct consequence of the insertion of the amine–boranes in a polymeric scaffold, and not from a direct modification of the electronics or sterics of the amine–borane function. Finally, the mixture of polystyrene‐g‐boramines with conventional NH3‐BH3 (borazane) allows for a direct access to organic/inorganic hybrid dihydrogen reservoirs with a maximal H2 loading of 8 wt %. These exhibit a dehydrogenation temperature lower than that of either the borazane or the polystyrene‐g‐boramines taken separately.
Bridging Crystal Engineering and Drug Discovery by Utilizing Intermolecular Interactions and Molecular Shapes in Crystals
Authors: Spackman Peter R. , Yu Li‐Juan , Morton Craig J. , Parker Michael W. , Bond Charles S. , Spackman Mark A. , Jayatilaka Dylan , Thomas Sajesh P. 
Published: August 2019

AbstractMost structure‐based drug discovery methods utilize crystal structures of receptor proteins. Crystal engineering, on the other hand, utilizes the wealth of chemical information inherent in small‐molecule crystal structures in the Cambridge Structural Database (CSD). We show that the interaction surfaces and shapes of molecules in experimentally determined small‐molecule crystal structures can serve as effective tools in drug discovery. Our description of the shape and interaction propensities of molecules in their crystal structures can be used to screen them for specific binding compatibility with protein targets, as demonstrated through the high‐throughput profiling of around 138 000 small‐molecule structures in the CSD and a series of drug–protein crystal structures. Electron‐density‐based intermolecular boundary surfaces in small‐molecule crystal structures and in target‐protein pockets are utilized to identify potential ligand molecules from the CSD based on 3D shape and intermolecular interaction matching.
Cationic organotin cluster [t‐Bu2Sn(OH)(H2O)]22+2OTf−‐catalyzed one‐pot three‐component syntheses of 5‐substituted 1H‐tetrazoles and 2,4,6‐triarylpyridines in water
Authors: Wang Hongshe , Zhao Weixing , Du Juan , Wei Fenyan , Chen Qi , Wang Xiaomei 
Published: August 2019

The cationic organotin cluster [t‐Bu2Sn(OH)(H2O)]22+2OTf− is easy to prepare and stable in air. The catalytic activity of [t‐Bu2Sn(OH)(H2O)]22+2OTf− as a neutral organotin Lewis acid catalyst is probed through the one‐pot three‐component syntheses of 5‐substituted 1H‐tetrazoles from aldehydes, hydroxylamine hydrochloride and sodium azide, and of 2,4,6‐triarylpyridines from aromatic aldehydes, substituted acetophenones and ammonium acetate. The reactions proceed well in the presence of 1 mol% of [t‐Bu2Sn(OH)(H2O)]22+2OTf− in water and provide the corresponding 5‐substituted 1H‐tetrazoles and 2,4,6‐triarylpyridines in good to excellent yields. The method reported has several advantages such as the catalyst being neutral, low catalyst loading and use of water as a green solvent.
Retardation of Crystallization through the Addition of Dairy Phospholipids
Authors: Cooper Zachary , Simons Casey , Martini Silvana 
Published: August 2019

AbstractThe objective of this work was to identify the effects that milk phospholipids (PL) have on crystallization of anhydrous milk fat (AMF). Three mixtures were prepared by adding 0%, 0.01%, and 0.1% PL to AMF. Each mixture was crystallized for 90 min at 24, 26, and 28 °C. The solid fat content was measured as a function of time and fitted to the Avrami equation. Melting point, thermal behavior, viscoelastic properties, and crystal morphology were all measured at 90 min. All assays were repeated, as well as hardness, after being stored at 5 °C for 48 hours. Samples containing PL showed slower crystallization as concentration increased especially at higher temperatures (26 and 28 °C). The addition of PL caused a difference in crystal morphology resulting in visibly larger crystals at 90 min. The elasticity and hardness at 90 min were influenced by the addition of PL at 24 °C with lower values obtained in samples with PL compared to the AMF alone. No differences in hardness nor in elasticity was observed for samples crystallized at 26 and 28 °C. A decrease in melting enthalpy was observed in samples with PL indicating a reduction in crystallization at all temperatures, which was supported by crystal morphology.
Knockdown of arylalkylamine N‐acetyltransferase‐like 2 in Drosophila melanogaster
Authors: Anderson Ryan L. , Wallis Dylan J. , Aguirre Alexander , Holliday Dean , Merkler David J. 
Published: August 2019

AbstractDrosophila melanogaster produces fatty acid amides, and thus, provides a model to unravel the pathways for their biosynthesis. We previously demonstrated that arylalkylamine N‐acetyltransferase‐like 2 (AANATL2) from D. melanogaster will catalyze the formation of long‐chain N‐acylserotonins and N‐acyldopamines in vitro. Generating silencing RNA via the UAS/GAL4 bipartite approach for targeted gene expression effectively decreased the endogenous levels of the AANATL2 transcripts in D. melanogaster, as shown by reverse transcription quantitative polymerase chain reaction. Consistent with these data, western blot analysis of the offspring of the AANATL2 knockdown flies using an anti‐AANATL2 antibody revealed a significant reduction in the expression of the AANATL2 protein. Reduced expression of AANATL2 decreased the cellular levels of N‐palmitoyldopamine (PALDA), providing strong evidence that AANATL2 is responsible for the biosynthesis of PALDA in vivo. This is the first time that the expression of an AANAT has been reduced in D. melanogaster to link one of these enzymes to the in vivo production of an N‐acylarylalkylamide.
Decade‐long X‐ray observations of HESS J0632+057
Authors: Malyshev Denys , Chernyakova Maria , Santangelo Andrea , Pühlhofer Gerd 
Published: August 2019

AbstractWe present the results of a decade of X‐ray observations of the gamma ray loud binary HESS J0632+057 and interpret the available broadband data in view of the system geometry and emission mechanisms. We have performed an analysis of all X‐ray data available to date from Swift, XMM‐Newton, Chandra, NuSTAR, and Suzaku. We refine the orbital period of the system to be days (95% c.l.), consistent with previous studies but measured with significantly better accuracy. We report on a hydrogen column density and spectral slope variation along the orbit. We argue that the observed variability can be explained within an “inclined disk” model in which the orbit of the compact object is inclined to the disk of the Be star. We show that the observed X‐ray to TeV emissions can originate from a broken cut‐off power‐law population of electrons and describe a way in which future X‐ray/TeV observations can distinguish between the proposed model and the alternative flip‐flop emission scenario of this system.
Implication of hypocholesterolemia in autism spectrum disorder and its associated comorbidities: A retrospective case–control study
Authors: Benachenhou Sérine , Etcheverry Antoine , Galarneau Luc , Dubé Jean , Çaku Artuela 
Published: August 2019

Autism spectrum disorder (ASD) has been associated with low cholesterol levels in a limited number of studies. However, the prevalence of hypocholesterolemia as well as the degree of association with ASD remains to be elucidated. We therefore sought to investigate the lipid profiles of a group of French‐Canadian ASD individuals. The medical records of 79 ASD individuals and 79 age and gender‐matched healthy controls were retrospectively reviewed. The fasting lipid profiles including total cholesterol (TC), high‐density lipoprotein, triglycerides, and low‐density lipoprotein were extracted for individuals of both groups along with the following clinical data: anthropometric measurements, medication use and associated disorders. Lipid parameters were compared to age and gender‐based normative population and categorized in centile groups. The prevalence of hypocholesterolemia was revealed to be more than threefold higher in ASD individuals as compared to the general population (23%; P = 0.005). The 25th centile was determined as a potential TC threshold that could best predict the ASD (odds ratio [OR] = 3.04; 95% confidence interval [CI]: 1.58–6.65; P < 0.001). This study identified specific ASD comorbidities associated with hypocholesterolemia: TC levels below the 10th centile were associated with a higher rate of ASD‐associated intellectual disability (OR = 3.33; 95% CI: 1.26–8.00) and anxiety/depression (OR = 4.74; 95% CI: 1.40–15.73). Overall, these results support a potential association between hypocholesterolemia and ASD occurrence. Application of this study to larger populations is urging to provide more extensive data that may further elucidate the association between hypocholesterolemia and ASD. Autism Res 2019, 12: 1860–1869. © 2019 International Society for Autism Research, Wiley Periodicals, Inc.Lay SummaryAssociation of autism spectrum disorder (ASD) with abnormally low levels of cholesterol (hypocholesterolemia) has been documented before. These studies were incomplete, and the conclusion remains speculative. Here, we reviewed the medical records of 79 French‐Canadian ASD individuals and compared their total cholesterol (TC) levels to healthy individuals matched for age and gender. We observed four times more hypocholesterolemia in ASD than in the general population. Furthermore, low TC in ASD was associated with higher rates of ASD‐associated intellectual disability and anxiety/depression. Our results support an association between hypocholesterolemia and ASD and open novel opportunities for the diagnosis and treatment of specific forms of ASD.
The role of motivation and volition in economic decisions: Evidence from eye movements and pupillometry
Authors: Ludwig Jonas , Jaudas Alexander , Achtziger Anja 
Published: August 2019

AbstractEconomic decisions usually involve high stakes, real consequences, and some degree of personal risk. This article explores the impact of motivational and volitional states on economic decision processes in an incentivized lottery choice task. We investigated the patterns of decision time, choice, information search, and pupil dilation dependent on an experimental manipulation of motivation and volition, that is, the deliberative and the implemental mindset. The results indicated that choice preferences in economic decisions were robust and remained unaffected by motivational and volitional states, but decision processes were notably impacted. Decision makers in a deliberative state of mind searched for information more extensively and made slower decisions than the baseline. The implemental mindset was associated with more attention paid to the probability attributes of the gambles relative to the deliberative mindset. Furthermore, we observed that gamble outcomes that entailed no win at all (i.e., zero outcomes) played an important role for information search. These outcomes were largely disregarded in terms of predecisional information search but elicited pupillary responses similar to very high outcome lotteries. These results inform the current debate about the zero effect in risky choice. We also discuss the potential of eye‐tracking studies of risky choice to dissolve ambiguities concerning the contributions of effort and arousal to modulating pupillary response. Implications for theoretical advances in decision research are discussed.