bluuebunny/crossref_metadata_2025_split huggingface dataset:
Randomized Phase II Trial of Bevacizumab or Temsirolimus in Combination With Chemotherapy for First Relapse Rhabdomyosarcoma: A Report From the Children’s Oncology Group
Authors: Mascarenhas Leo , Chi Yueh-Yun , Hingorani Pooja , Anderson James R. , Lyden Elizabeth R. , Rodeberg David A. , Indelicato Daniel J. , Kao Simon C. , Dasgupta Roshni , Spunt Sheri L. , Meyer William H. , Hawkins Douglas S. 
Published: September 2019

PURPOSEThe primary aim of this clinical trial was to prioritize bevacizumab or temsirolimus for additional investigation in rhabdomyosarcoma (RMS) when administered in combination with cytotoxic chemotherapy to patients with RMS in first relapse with unfavorable prognosis.PATIENTS AND METHODSPatients were randomly assigned to receive bevacizumab on day 1 or temsirolimus on days 1, 8, and 15 of each 21-day treatment cycle, together with vinorelbine on days 1 and 8, and cyclophosphamide on day 1 for a maximum of 12 cycles. Local tumor control with surgery and/or radiation therapy was permitted after 6 weeks of treatment. The primary end point was event-free survival (EFS). Radiographic response was assessed at 6 weeks. The study had a phase II selection that was design to detect a 15% difference between the two regimens (α = .2; 1-β = 0.8; two sided test).RESULTSEighty-seven of 100 planned patients were enrolled when the trial was closed after the second interim analysis after 46 events occurred in 68 patients with sufficient follow-up. The O’Brien Fleming boundary at this analysis corresponded to a two-sided P value of .058 with an observed two-sided P value of .003 favoring temsirolimus. The 6-month EFS for the bevacizumab arm was 54.6% (95% CI, 39.8% to 69.3%) and 69.1% (95% CI, 55.1% to 83%) for the temsirolimus arm. Objective response rates were 28% (95% CI, 13.7% to 41.3%) and 47% (95% CI, 31.5% to 63.2%) for the bevacizumab and temsirolimus arms, respectively ( P = .12) and, 28% of patients on bevacizumab and 11% on temsirolimus had progressive disease at 6 weeks.CONCLUSIONPatients who received temsirolimus had a superior EFS compared with bevacizumab. Temsirolimus has been selected for additional investigation in newly diagnosed patients with intermediate-risk RMS.
Are National Comprehensive Cancer Network Evidence Block Affordability Ratings Representative of Real-World Costs? An Evaluation of Advanced Non–Small-Cell Lung Cancer
Authors: Cohen Joshua T. , Lin Pei-Jung , Sheinson Daniel M. , Wong William B. , Wu Ning , Yim Yeun Mi , Ramsey Scott D. 
Published: September 2019

PURPOSE: The National Comprehensive Cancer Network (NCCN) developed the Evidence Blocks framework to assess the value of oncology regimens. This study characterizes the relationship between real-world costs and NCCN affordability ratings (ARs) for advanced non–small-cell lung cancer (aNSCLC) treatments. METHODS: Using the MarketScan and PharMetrics Plus databases, we identified patients treated between 2012 and 2017 with an aNSCLC regimen evaluated by the NCCN Evidence Blocks. We estimated adjusted mean total per-patient-per-month (PPPM) costs and drug costs for each regimen using a log-linked gamma generalized linear model. Weighted regression was used to examine the correlation between adjusted mean PPPM costs per regimen and NCCN AR. RESULTS: A total of 25,162 patients with aNSCLC (mean age, 63 years [standard deviation, 10 years]; 52% male) had identifiable regimens. Mean total PPPM cost by therapeutic class ranged from $16,824 for epidermal growth factor receptors to $41,815 for immunotherapy-based treatment. Epidermal growth factor receptor and anaplastic lymphoma kinase inhibitor treatment had lower ARs compared with generic chemotherapy. No therapy was listed as AR group 5 (least expensive). In pairwise comparisons, AR group 1 had significantly higher PPPM total costs compared with AR groups 2 and 4. There were no significant differences in PPPM total cost among AR groups 2, 3, and 4. CONCLUSION: Real-world aNSCLC treatment costs are often inconsistent with the NCCN ARs. Given that NCCN Evidence Blocks are intended to inform provider-patient discussions and other decision support resources, such as the NCCN Categories of Preference, our results suggest that the NCCN ARs require further refinement and validation.
Opioids and Their Endocrine Effects: A Systematic Review and Meta-analysis
Authors: de Vries Friso , Bruin Mees , Lobatto Daniel J , Dekkers Olaf M , Schoones Jan W , van Furth Wouter R , Pereira Alberto M , Karavitaki Niki , Biermasz Nienke R , Zamanipoor Najafabadi Amir H 
Published: September 2019

AbstractContextThe increased use of opioids has resulted in an unprecedented opioid epidemic. Chronic opioid use causes hypogonadism, but its frequency, as well as the effects of opioids on other hypothalamo–pituitary–end organ hormone axes, remains unclear.ObjectiveThe aim of this systematic review and meta-analysis was to assess the effects of opioid use on pituitary function.MethodsEight electronic databases were searched for articles published up to May 8, 2018. Fixed or random effects meta-analysis was performed to estimate pooled proportions with 95% confidence intervals (CI). This study is reported following the PRISMA and MOOSE guidelines.Data synthesis52 studies (22 low risk of bias) were included describing 18 428 subjects, consisting of patients with chronic pain (n = 21 studies) or on maintenance treatment for opioid addiction (n = 9) and healthy volunteers (n = 4). The most frequently used opioid was methadone (n = 13 studies), followed by morphine (n = 12). Prevalence of hypogonadism was 63% (95% CI: 55%–70%, 15 studies, 3250 patients, 99.5% males). Prevalence of hypocortisolism relying on dynamic and nondynamic testing was 15% (95% CI: 6%–28%, 5 studies, 205 patients, 57.5% males) and including only studies using the insulin tolerance tests 24% (95% CI 16%–33%, 2 studies, n = 97 patients). In 5 out of 7 studies, hyperprolactinemia was present. No clear effects on the somatotropic and hypothalamo–pituitary–thyroid axes were described.ConclusionsHypogonadism occurs in more than half of male opioid users, and hypocortisolism in approximately one-fifth of all patients. Periodical evaluation of at least the gonadal and adrenal axes is therefore advisable.
Loss of DNA methyltransferase activity in primed human ES cells triggers increased cell-cell variability and transcriptional repression
Authors: Tsankov Alexander M. , Wadsworth Marc H. , Akopian Veronika , Charlton Jocelyn , Allon Samuel J. , Arczewska Aleksandra , Mead Benjamin E. , Drake Riley S. , Smith Zachary D. , Mikkelsen Tarjei S. , Shalek Alex K. , Meissner Alexander 
Published: September 2019

ABSTRACT
Maintenance of pluripotency and specification towards a new cell fate are both dependent on precise interactions between extrinsic signals and transcriptional and epigenetic regulators. Directed methylation of cytosines by the de novo methyltransferases DNMT3A and DNMT3B plays an important role in facilitating proper differentiation, whereas DNMT1 is essential for maintaining global methylation levels in all cell types. Here, we generated single-cell mRNA expression data from wild-type, DNMT3A, DNMT3A/3B and DNMT1 knockout human embryonic stem cells and observed a widespread increase in cellular and transcriptional variability, even with limited changes in global methylation levels in the de novo knockouts. Furthermore, we found unexpected transcriptional repression upon either loss of the de novo methyltransferase DNMT3A or the double knockout of DNMT3A/3B that is further propagated upon differentiation to mesoderm and ectoderm. Taken together, our single-cell RNA-sequencing data provide a high-resolution view into the consequences of depleting the three catalytically active DNMTs in human pluripotent stem cells.
Genetic heterogeneity within collective invasion packs drives leader and follower cell phenotypes
Authors: Zoeller Elizabeth L. , Pedro Brian , Konen Jessica , Dwivedi Bhakti , Rupji Manali , Sundararaman Niveda , Wang Lei , Horton John R. , Zhong Chaojie , Barwick Benjamin G. , Cheng Xiaodong , Martinez Elisabeth D. , Torres Matthew P. , Kowalski Jeanne , Marcus Adam I. , Vertino Paula M. 
Published: September 2019

ABSTRACT
Collective invasion, the coordinated movement of cohesive packs of cells, has become recognized as a major mode of metastasis for solid tumors. These packs are phenotypically heterogeneous and include specialized cells that lead the invasive pack and others that follow behind. To better understand how these unique cell types cooperate to facilitate collective invasion, we analyzed transcriptomic sequence variation between leader and follower populations isolated from the H1299 non-small cell lung cancer cell line using an image-guided selection technique. We now identify 14 expressed mutations that are selectively enriched in leader or follower cells, suggesting a novel link between genomic and phenotypic heterogeneity within a collectively invading tumor cell population. Functional characterization of two phenotype-specific candidate mutations showed that ARP3 enhances collective invasion by promoting the leader cell phenotype and that wild-type KDM5B suppresses chain-like cooperative behavior. These results demonstrate an important role for distinct genetic variants in establishing leader and follower phenotypes and highlight the necessity of maintaining a capacity for phenotypic plasticity during collective cancer invasion.
Determination of the Distribution of Ferric Chloro Complexes in Hydrochloric Acid Solutions at 298 K
Authors: Uchikoshi Masahito 
Published: September 2019

Abstract
Understanding the intrinsic nature of materials requires ultrahigh-purity materials because impurities affect various properties. Ion-exchange separation is one of the most promising purification technologies; however, the thermodynamic details of the ion-exchange reaction have not been made clear. The condition of metal species in the solution phase is fundamental to investigating the ion-exchange reaction. In this paper, the distribution of ferric chloro complexes in hydrochloric acid solutions was investigated by factor analysis of UV-Vis absorption spectra, followed by fitting analysis of a theoretical model to individual molar attenuation coefficients obtained by mathematical decomposition of UV-Vis absorption spectra. Five ferric species were detected by principal component analysis using a novel index proposed in this paper. In the results of factor analysis followed by fitting analysis, [FeIII]3+, [FeIIICl]2+, [FeIIICl2]+, [FeIIICl3]0, and [FeIIICl4]− were identified. The activity coefficients of charged species in concentrated aqueous solutions were estimated by using a modified Debye-Hückel equation. The thermodynamic parameters of the four cumulative formation constants and a Setchénow coefficient for neutral species of [FeIIICl3]0 were determined. The adsorbability of ferric, cupric, and cobalt species to an anion exchanger from hydrochloric acid solutions was qualitatively discussed using the results obtained in this paper.
Carbon Dioxide Hydrosilylation to Methane Catalyzed by Zinc and Other First-Row Transition Metal Salts
Authors: Zhang Qiao , Fukaya Norihisa , Fujitani Tadahiro , Choi Jun-Chul 
Published: September 2019

Abstract
We accomplished zinc catalyzed hydrosilylation of carbon dioxide (CO2) to silyl formate (C+II), bis(silyl)acetal (C0), methoxysilane (C−II), and finally methane (C−IV). Among several zinc salts, we found that Zn(OAc)2 with ligand 1,10-phenanthroline was the best. A turnover number of 815000 was achieved using the zinc catalyst to yield C+II. Unexpectedly, we observed the generation of CO from CO2 and hydrosilane for the first time. In addition to Zn, other first-row transition metals (Mn, Fe, Co, Ni, and Cu) also served as Lewis acid catalysts for CO2 hydrosilylation, regardless of the nature of the metal.
Person-Centred Dermatology Self-care Index: a translation and validation study
Authors: Kottner Jan , Ludwig Oliver , Bode Thomas , Cowdell Fiona , Ersser Steven , Blume-Peytavi Ulrike , Lahmann Nils 
Published: September 2019

Objective:Self-management is important to successfully managing chronic skin diseases. The Person-Centred Dermatology Self-care Index (PeDeSI) is a self-efficacy theory-based questionnaire tool to measure education and support needs of adults with long-term skin conditions. The aim of this research was to translate the PeDeSI into German (PeDeSI-G) and to explore the validity of this tool.Methods:The instrument was translated by five translators working independently. User understanding and relevance were evaluated by nurses, patients and physicians. The translated version was modified and applied in a subsequent validation study. Demographic and other variables, PeDeSI-G and Dermatology Life Quality Index (DLQI) scores of dermatological patients were obtained.Results:PeDeSi-G and DLQI scores were obtained from 100 patients. A conceptually and semantically equivalent German translation of the PeDeSI was developed. There was a statistically significant difference between in- and outpatients (p<0.001). PeDeSI-G scores were most strongly correlated with disease duration and DLQI scores.Conclusions:Validation results indicate that the PeDeSI-G is able to discriminate between patients with different educational and support needs for this patient group. Newly diagnosed patients and patients admitted to the hospital for the first time might benefit most from the PeDeSI-G assessment. The PeDeSI-G is a valid tool for assessing and evaluating the support needs of German-speaking patients with chronic skin disease.
Brief Report: Calculation and Convergent and Divergent Validity of a New ADOS-2 Expressive Language Score
Authors: Mazurek Micah O. , Baker-Ericzén Mary , Kanne Stephen M. 
Published: September 2019

Abstract
Despite the importance of expressive language for individuals with autism spectrum disorder (ASD), expressive language assessments are not consistently included in ASD research and many studies do not adequately describe participants' verbal abilities. A valid and efficient measure of expressive language would facilitate consistent reporting across ASD research studies and provide data for additional analyses. The current study developed a new Autism Diagnostic Observation Schedule (ADOS-2) expressive language score and examined convergent and divergent validity in a large, well-defined sample of children with ASD. This score was highly correlated with other measures of expressive language (including parent-report, direct assessment, and clinician ratings) and less strongly correlated with measures of receptive language and nonverbal cognitive ability, providing good evidence of convergent and divergent validity.
Behavioral Treatment of Self-Injury: 2001 to 2016
Authors: Shawler Lesley A. , Russo Samantha R. , Hilton Jennifer L. , Kahng SungWoo , Davis Cheryl J. , Dorsey Michael F. 
Published: September 2019

AbstractIndividuals diagnosed with intellectual and developmental disabilities (IDD) frequently exhibit self-injurious behavior (SIB). Previous research has examined the published literature on behavioral treatments of SIB from 1964–2000. Results suggested that these treatments were highly efficacious at decreasing SIB, particularly when based on the results of a functional assessment. The purpose of this review is to update, replicate, and extend the previous research. The current findings indicate an increase in studies reporting automatically maintained SIB as well as less efficacious treatments overall. Discussion of our conclusions and methods of SIB assessment and treatment are discussed, both as they relate to the previous review and for future directions.
Self-Reported Guilt Among Adult Siblings of People With Intellectual and Developmental Disabilities
Authors: Shivers Carolyn M. 
Published: September 2019

Abstract
As more siblings become responsible for their aging brothers and sisters with intellectual and developmental disabilities, it becomes increasingly important to understand these siblings' emotional needs, including potential negative emotions such as guilt. This study examined the presence and correlates of self-reported guilt among 1,021 adult siblings of people with intellectual and developmental disabilities. Respondents completed the Adult Sibling Questionnaire, a national survey examining characteristics of adult health, depression, and feelings of guilt. Over 50% of siblings reported feeling increased guilt. Siblings who experienced increased guilt (versus those who did not) experienced less close sibling relationships, more depressive symptoms, and lower levels of well-being. Siblings experiencing more guilt also had brothers/sisters with more severe emotional/behavioral problems.
Islam dan Resolusi Konflik
Authors: Harjuna Muhamad 
Published: September 2019

AbstractThis article examines the essence of religion and specifically speaks of Islam as a peaceful, progressive and solutive religion. Islam comes from the Most Peaceful (al-Salâm), always spreading peace wherever and whenever. The greetings spoken by Muslims reflect the noble character of the Assalamu'alaikum (may peace be upon you). Islam is a progressive religion, against oppressors, capitalists, injustices, fighting for the rights of the oppressed little ones, glorifying women, and bringing about a harmonious and peaceful society within the framework of fraternity. Islam is a solutive religion, teaches the virtues of morality as opposed to bad morality, resolves nonviolent conflict, and contributes to giving spirit to build peace or conflict resolution, and also contributes in giving spirit to build peace or conflict resolution. The Qur'an’s solution to conflict is a suggestion for clarification, mediation, deliberation, forgiveness, reconciliation, good deeds, and justice. A holistic study of Islam will find the substance of Islam as a religion of raḥmatan lil 'âlamḭn.
STRATEGI PENGEMBANGAN UMKM HALAL DI JAWA TENGAH DALAM MENGHADAPI PERSAINGAN GLOBAL
Authors: Pujiono Arif , Setyawati Ro'fah , Idris I 
Published: September 2019

Abstrak Jawa Tengah sebagai bagian integral negara Indonesia memiliki potensi besar berupa Usaha Mikro Kecil dan Menengah (UMKM) halal dalam mendukung pembangunan. Sebagai wilayah dengan jumlah penduduk muslim yang besar dan memiliki jumlah UMKM terbanyak dan beraneka ragam, ternyata UMKM halal di Jawa Tengah belum mampu bersaing secara global. Penelitian ini memiliki tujuan utama untuk menetapkan strategi pengembangan UMKM halal di Jawa Tengah dalam menghadapi persaingan global. Metode yang digunakan adalah analisis statistik deskriptif melalui kuesioner terstruktur, indepth interview, focus group discussion (FGD) dengan tokoh kunci (key persons) dan analisis strenghts, weaknesses, oppotunities, dan threats (SWOT). Berdasarkan hasil analisis SWOT , maka strategi yang dapat dikembangkan untuk meningkatkan daya saing UMKM halal di Jawa Tengah adalah meningkatkan sertifikasi UMKM halal, meningkatkan kualifikasi SDM UMKM halal, menggunaan teknologi modern dan tepat guna untuk memenuhi standar produk UMKM halal, pemperkuat keterkaitan dengan industri (hilirisasi), melakukan diversifikasi produk UMKM halal, Meningkatkan peran lembaga keagamaan dan pendidikan untuk literasi produk UMKM halal kepada masyarakat muslim, meningkatkan peran fintech untuk pembiayaan dan sertifikasi produk UMKM halal beserta pemasarannya, membangun sinergi dengan institusi terkait untuk inovasi produk UMKM halal, meningkatkan branding produk UMKM halal melalui media teknologi dan informasi, memperkuat kajian fikih untuk menghasilkan produk UMKM halal Kata kunci: UMKM halal, Jawa Tengah, strategi pengembangan, dan SWOT
The Mechanism and Control Technology of Strong Strata Behavior in Extra-Thick Coal Seam Mining Influenced by Overlying Coal Pillar
Authors: Gao Rui , Kuang Tiejun , Lan Yiwen 
Published: September 2019

Abstract
This work aimed at revealing the mechanism of strong strata behavior in extra-thick coal seam mining which was influenced by an overlying coal pillar (OCP). To this end, the evolution characteristics of the stress and displacement in advance coal body of the working face were studied via numerical simulation. On this basis, the mechanism of strong strata behavior in working face affected by OCP was revealed. In situ monitoring also demonstrated that, as the working face mining near to the position of OCP, severe rib spalling and roadway deformation frequently appeared. The scheme of strengthening the hydraulic supports resistance and adding anchor cables was put forward to control the surrounding rocks in the stope. As a result, the maximum deformation of the roadway height was 0.66m and could completely meet the demands for safe mining. The study on the mechanism of strong strata behavior in working face and the strengthen supporting scheme would provide a theoretical basis for similar mining conditions, thus ensure safe and efficiency coal seam mining.
Numerical Simulation of Flow Distribution in the Reactor Used for CFRPs Degradation under Supercritical Condition
Authors: Cheng Huanbo , Liu Weihao , Huang Haihong , Liu Zhifeng 
Published: September 2019

Abstract
Supercritical fluids with excellent decomposition and mass transfer capabilities can degrade the resin matrix of carbon fiber reinforced polymer (CFRPs) to recycle high-performance carbon fibers. The degradation rate of CFRPs was influenced by the velocity and temperature distributions of supercritical fluids in the reactor with mechanical stirring. The flow field model in the reactor was established during the degradation of CFRPs by supercritical ethanol. The velocity and temperature distributions in both the axial and radial directions were simulated when the stirrer was installed in the reactor at different heights. The simulation indicated that the flow distribution was uneven in the reactor and the position with optimum flow distribution for placing CFRPs was 45 %–70 % of the installation distance between underside of the impeller and the base of the reactor. The experiment shows mechanical stirring can significantly promote CFRPs degradation. When the installing height of the stirrer is 110 mm, the degradation rate of the epoxy resin is 10 % higher than that without stirring. The degradation rate of epoxy resin was also affected by the placement position of CFRPs in the reactor, and could be improved by approximately 14 % higher than that without mechanical stirring when the CFRPs were placed in the position with optimum flow distribution.