bluuebunny/crossref_metadata_2025_split huggingface dataset:
Skin improvement is a surrogate for favourable changes in other organ systems in early diffuse cutaneous systemic sclerosis
Authors: Nevskaya Tatiana , Zheng Boyang , Baxter Carl A , Ramey Dena R , Pope Janet E , Baron Murray ,   for Canadian Scleroderma Research Group
Published: October 2019

AbstractObjectivesSkin improvement in diffuse cutaneous SSc (dcSSc), measured with modified Rodnan skin score (mRSS), is frequently used as a primary outcome in clinical trials, but it is uncertain whether mRSS changes reflect changes in other organ systems. This aim of this study was to explore if skin changes in early dcSSc over 1 and 2 years are associated with changes in severity of other organ involvement.MethodsCanadian Scleroderma Research Group database patients with dcSSc, disease duration of ≤5 years, no evidence of initial end-stage organ damage and/or significant comorbidity who had 1 year (n = 154) and 2 years (n = 128) of follow-up data were included. mRSS changes of 25% and/or ≥5 points were considered significant. Organ involvement was assessed by Medsger Disease Severity Score and Canadian Scleroderma Research Group definitions using bivariate, chi-square, ANOVA, adjusted regression and longitudinal mixed effect model analyses.ResultsImprovement in mRSS was found in 41% of patients at 1 year and in 50% at 2 years. Improved patients showed less forced vital capacity decline (P = 0.012) and less frequent new cardiac involvement (P = 0.02) over 1 year, as well as better lung (by both Disease Severity Score, P = 0.006, and Δforced vital capacity%, P = 0.026), peripheral vascular (P = 0.006) and joint/tendon (P = 0.002) involvement over 2 years. mRSS worsening was consistently linked to less favourable lung outcomes at both 1- and 2-year follow-up visits, and more severe gastrointestinal disease at 2 years.ConclusionChanges in lung function in early dcSSc closely parallel skin changes. mRSS improvement reflects better prognosis for visceral disease and may be a reliable outcome measure in clinical trials.
The effect of ethnicity and team membership on face processing: a cultural neuroscience perspective
Authors: Yan Zhimin , Schmidt Stephanie N L , Saur Sebastian , Kirsch Peter , Mier Daniela 
Published: October 2019

AbstractIn-ethnicity bias, as one of the in-group biases, is widespread in different cultures, interfering with cross-ethnicity communication. Recent studies have revealed that an in-ethnicity bias can be reduced by an in-team bias caused by the membership in a mixed-ethnicity team. However, the neural correlates of different in-group biases are still not clear, especially regarding possible cultural differences. A total of 44 participants (20 Chinese and 24 Germans) were recruited and completed a social categorization fMRI-task, categorizing faces according to their ethnicity and a learned team membership. Our behavioral results revealed both in-ethnicity and in-team bias in German participants, but not in Chinese participants. Our imaging results, however, showed both biases across all participants, as reflected in increased dorsal medial frontal cortex (MFC) activation for in-ethnicity, as well as in-team categorizations, while activation in ventral MFC was higher for in-ethnicity faces in Chinese participants than in the German participants. Our results highlight the importance of the dorsal MFC for in-group categorization across cultures and suggest that cultures might modulate in-group biases.
Hyaluronic Acid Filler Injections for Nasolabial Folds in Asian Patients
Authors: Zhao Minghao , Cai Lei , Li Facheng , Han Xuefeng 
Published: October 2019

Background
There are multiple techniques used to inject hyaluronic acid to minimize the appearance of nasolabial folds. These techniques vary in accordance with the etiology of the nasolabial folds. Based on our understanding of nasolabial anatomy and our experience with the injection of hyaluronic acid fillers, we herein summarize a systemic treatment plan based on a practical nasolabial fold assessment method.

Methods
From November 2015 to December 2017, 180 patients received hyaluronic acid injections in our clinic to improve the appearance of nasolabial folds. All patients were followed up for at least 1 month. All patients underwent our nasolabial fold assessment and were then treated with an appropriate plan. The therapeutic effect was assessed via the photonumeric wrinkle assessment scale. Patients with complications were monitored for up to 1 year. A follow-up survey was performed 1 month postoperatively, with the outcome rated as excellent, satisfactory, moderate, or unsatisfactory.

Results
Patients demonstrated a significant improvement in the appearance of the nasolabial folds. No infection or vascular complications occurred. The 1-month follow-up survey revealed that the patient satisfaction rate was 96.7% (excellent or satisfactory outcome).

Conclusion
This systemic treatment method for nasolabial folds is effective, safe, and practical.
Prognostic value of the Residual Cancer Burden index according to breast cancer subtype: validation on a cohort of BC patients treated by neoadjuvant chemotherapy
Authors: Hamy Anne-Sophie , Darrigues Lauren , Laas Enora , De Croze Diane , Topciu Lucian , Lam Giang-Thanh , Evrevin Clémence , Rozette Sonia , Laot Lucie , Lerebours Florence , Pierga Jean-Yves , Osdoit Marie , Faron Matthieu , Feron Jean-Guillaume , Laé Marick , Reyal Fabien 
Published: October 2019

ABSTRACTIntroductionThe Residual Cancer Burden (RCB) quantifies residual disease after neoadjuvant chemotherapy (NAC). Its predictive value has not been validated on large cohorts with long-term follow up. The objective of this work is to independently evaluate the prognostic value of the RCB index depending on BC subtypes (Luminal, HER2-positive and triple negative (TNBCs)).MethodsWe retrospectively evaluated the RCB index on surgical specimens from a cohort of T1-T3NxM0 BC patients treated with NAC between 2002 and 2012. We analyzed the association between RCB index and relapse-free survival (RFS), overall survival (OS) among the global population, after stratification by BC subtypes.Results717 patients were included (luminal BC (n = 222, 31%), TNBC (n = 319, 44.5%), HER2-positive (n = 176, 24.5%)). After a median follow-up of 99.9 months, RCB index was significantly associated with RFS. The RCB-0 patients displayed similar prognosis when compared to the RCB-I group, while patients from the RCB-II and RCB-III classes were at increased risk of relapse (RCB-II versus RCB-0: HR=3.25 CI [2.1-5.1] p<0.001; RCB-III versus RCB-0: HR=5.6 CI [3.5-8.9] p<0.001). The prognostic impact of RCB index was significant for TNBC and HER2-positive cancers; but not for luminal cancers (Pinteraction = 0.07). The prognosis of RCB-III patients was poor (8-years RFS: 52.7%, 95% CI [44.8 – 62.0]) particularly in the TNBC subgroup, where the median RFS was 12.7 months.ConclusionRCB index is a reliable prognostic score. RCB accurately identifies patients at a high risk of recurrence (RCB-III) with TNBC or HER2-positive BC who must be offered second-line adjuvant therapies.
Assessing circular RNAs in Alzheimer disease
Authors: Cervera-Carles Laura , Dols-Icardo Oriol , Cervantes-Gonzalez Alba , Molina-Porcel Laura , Muñoz-Llahuna Laia , Clarimon Jordi 
Published: October 2019

AbstractCircular RNAs (circRNA) are evolutionary conserved non-coding RNAs resulting from the backsplicing of precursor messengers. Recently, a circular-transcriptome-wide study of circRNA in brain tissue from patients with Alzheimer’s disease (AD) has revealed a striking association between the expression of circRNA and AD pathological diagnosis. In the present study, we aimed at replicating the major findings in an independent case series comprising definitive sporadic and familial AD. In order to assess the specificity of circRNA changes, we also included cases with frontotemporal lobar degeneration (FTLD), comprising brain specimens with TDP-43 aggregates (FTLD-TDP43) and samples that presented Tau accumulation (FTLD-Tau). Through a quantitative PCR approach, we evaluated a total of eight circRNAs that surpassed the significant threshold in the former meta-analysis (circHOMER1, circDOCK1, circKCNN2, circMAN2A1, circFMN1, circRTN4, circMAP7, and circPICALM). Average expression changes between AD patients and controls followed the same directions as previously reported, suggesting an overall upregulation of circDOCK1, circMAP7, circMAN2A1, circRTN4 and circPICALM, and a downregulation of the remainder (circHOMER1, circFMN1 and circKCNN2) in AD brain tissue. We also confirmed an exacerbated alteration in circRNA expression in the Mendelian AD group compared to the sporadic forms. Two circRNAs, circHOMER1 and circKCNN2, also showed significant expression alterations in the group of FTLD-Tau and FTLD-TDP43, respectively. Overall, these results reinforce the conception that expression of circRNAs is altered in Alzheimer’s disease, and also suggest a wider involvement of this particular class of RNA in other neurodegenerative dementias.
High-resolution Linkage Map with Allele Dosage Allows the Identification of an Apomixis Region and Complex Traits in Guinea Grass (Megathyrsus maximus)
Authors: Deo Thamiris G. , Ferreira Rebecca C. U. , Lara Leticia A. C. , Moraes Aline C. L. , Alves-Pereira Alessandro , de Oliveira Fernanda A. , Garcia Antonio A. F. , Santos Mateus F. , Jank Liana , Souza Anete P. 
Published: October 2019

AbstractForage grasses are mainly used in animal feed to fatten cattle and dairy herds. Among tropical forage crops that reproduce by seeds, guinea grass (Megathyrsus maximus) is considered one of the most productive. This species has several genomic complexities, such as autotetraploidy and apomixis, due to the process of domestication. Consequently, approaches that relate phenotypic and genotypic data are incipient. In this context, we built a linkage map with allele dosage and generated novel information about the genetic architecture of traits that are important for the breeding ofM. maximus. From a full-sib progeny, a linkage map containing 858 single nucleotide polymorphism (SNP) markers with allele dosage information expected for an autotetraploid was obtained. The high genetic variability of the progeny allowed us to map ten quantitative trait loci (QTLs) related to agronomic traits, such as regrowth capacity and total dry matter, and 36 QTLs related to nutritional quality, which were distributed among all homology groups (HGs). Various overlapping regions associated with the quantitative traits suggested QTL hotspots. In addition, we were able to map one locus that controls apospory (apo-locus) in HG II. A total of 55 different gene families involved in cellular metabolism and plant growth were identified from markers adjacent to the QTLs and apomixis locus by using thePanicum virgatumgenome as a reference in comparisons with the genomes ofArabidopsis thalianaandOryza sativa. Our results provide a better understanding of the genetic basis of reproduction by apomixis and traits important for breeding programs that considerably influence animal productivity as well as the quality of meat and milk.
Parietal–prefrontal feedforward connectivity in association with schizophrenia genetic risk and delusions
Authors: Borrajo Danielle , La Michelle , Shah Shefali , Chen Qiang , Berman Karen F , Weinberger Daniel R , Tan Hao Yang 
Published: October 2019

AbstractBackgroundConceptualizations of delusion formation implicate, in part, deficits at feed-forward information transfer across posterior to prefrontal cortices, resulting in dysfunctional integration of new information in favor of over-familiar prior beliefs. Here, we used functional MRI and machine learning models to examine feedforward parietal-prefrontal information transfer in schizophrenia patients in relation to delusional thinking, and polygenic risk for schizophrenia.MethodsWe studied 66 schizophrenia patients and 143 healthy controls as they performed context updating during working memory (WM). Dynamic causal models of effective connectivity were focused on prefrontal and parietal cortex, where we examined parietal-prefrontal connectivity in relation to delusions in patients. We further tested for an effect of polygenic risk for schizophrenia on connectivity in healthy individuals. We then leveraged support vector regression models to define optimal normalized target connectivity tailored for each patient, and tested the extent to which deviation from this target predicted individual variation in delusion severity.ResultsIn schizophrenia patients, updating and manipulating context information was disproportionately less accurate than was WM maintenance, with a task accuracy-by-diagnosis interaction. Also, patients with delusions tended to have relatively reduced feedforward effective connectivity during context updating in WM manipulation. The same parietal-prefrontal feedforward prefrontal effective connectivity was adversely influenced by polygenic risk for schizophrenia in healthy subjects. Individual patients’ deviation from predicted ‘normal’ feedforward connectivity based on the support vector models correlated with delusional severity.ConclusionsThese computationally-derived observations support a role for feed-forward parietal-prefrontal information processing deficits in delusional psychopathology, and in genetic risk for schizophrenia.
Fibroblast-specific IL11 signaling is required for lung fibrosis and inflammation
Authors: Ng Benjamin , Dong Jinrui , Viswanathan Sivakumar , Widjaja Anissa A. , Paleja Bhairav S. , Adami Eleonora , Ko Nicole SJ. , Wang Mao , Lim Stella , Tan Jessie , Chothani Sonia P. , Albani Salvatore , Schafer Sebastian , Cook Stuart A. 
Published: October 2019

ABSTRACTTissue injury leads to activation of resident stromal, parenchymal and immune cells to initiate reparative processes that, if unresolved, can lead to fibrosis and organ damage. The directionality of effect between fibrosis and inflammation in the lung has been a point of debate for many years. Here, we tested the hypothesis that Interleukin 11 (IL11) signaling in fibroblasts is of primary importance for pulmonary fibrosis and that this event is upstream of lung inflammation. We generated mice with loxP-flankedIl11ra1alleles and crossed them to aCol1a2-CreERT strain to enableIl11ra1deletion in adult fibroblasts (Il11ra1-CKO mice). Lung fibroblasts fromIl11ra1-CKO mice were selectively deleted forIl11ra1and refractory to TGFβ1 stimulation. In the mouse model of bleomycin-induced lung fibrosis,Il11ra1-CKO mice had markedly reduced pulmonary fibrosis and lesser lung damage, which was accompanied by diminished ERK activation in the stromal compartment. Bleomycin lung injury inIl11ra1-CKO mice was also associated with diminished STAT3 activation in inflammatory cells, fewer pulmonary immune cell infiltrates and almost complete inhibition of NF-kB activation. These data reveal an essential role for IL11 signaling in fibroblasts for lung fibrosis and show that inflammation in the lung can be secondary to stromal activation.
Critical role for Slam/SAP signaling in the thymic developmental programming of IL-17- and IFN-γ-producing γδ T cells
Authors: Dienz Oliver , DeVault Victoria L. , Musial Shawn C. , Mistri Somen K. , Mei Linda , Baraev Aleksandr , Dragon Julie A. , Krementsov Dimitry , Veillette Andre , Boyson Jonathan E. 
Published: October 2019

AbstractDuring thymic development, γδ T cells commit to either an IFN-γ- or an IL-17-producing phenotype through mechanisms that remain unclear. Here, we investigated whether the SLAM/SAP signaling pathway played a role in the functional programming of thymic γδ T cells. Characterization of SLAM family receptor expression revealed that thymic γδ T cell subsets were each marked by distinct co-expression profiles of SLAMF1, SLAMF4, and SLAMF6. In the thymus, immature CD24hiVγ1 and Vγ4 γδ T cells were largely contained within a SLAMF1+SLAMF6+double positive (DP) population, while mature CD24lowsubsets were either SLAMF1+or SLAMF6+single positive (SP) cells. In the periphery, SLAMF1 and SLAMF6 expression on Vγ1, Vγ4, and Vγ6 T cells distinguished IL-17- and IFN-γ-producing subsets, respectively. Disruption of SLAM family receptor signaling through deletion of SAP resulted in impaired thymic γδ T cell maturation at the CD24hiSLAMF1+SLAMF6+DP stage that was associated with a decreased frequency of CD44+RORγt+γδ T cells. These defects were in turn associated with impaired γδ T cell IL-17 and IFN-γ production in both the thymus as well as in peripheral tissues. The role for SAP was subset-specific, as Vγ1, Vγ4, Vγ5, but not Vγ6 subsets were SAP-dependent. Together, these data suggest that the SLAM/SAP signaling pathway regulates a critical checkpoint in the functional programming of IL-17 and IFN-γ-producing γδ T cell subsets during thymic development.
Identification of critical factors for assessing the quality of restaurants using data mining approaches
Authors: Mahmood Ahsan , Khan Hikmat Ullah 
Published: October 2019

Purpose
The purpose of this paper is to apply state-of-the-art machine learning techniques for assessing the quality of the restaurants using restaurant inspection data. The machine learning techniques are applied to solve the real-world problems in all sphere of life. Health and food departments pay regular visits to restaurants for inspection and mark the condition of the restaurant on the basis of the inspection. These inspections consider many factors that determine the condition of the restaurants and make it possible for the authorities to classify the restaurants.

Design/methodology/approach
In this paper, standard machine learning techniques, support vector machines, naïve Bayes and random forest classifiers are applied to classify the critical level of the restaurants on the basis of features identified during the inspection. The importance of different factors of inspection is determined by using feature selection through the help of the minimum-redundancy-maximum-relevance and linear vector quantization feature importance methods.

Findings
The experiments are accomplished on the real-world New York City restaurant inspection data set that contains diverse inspection features. The results show that the nonlinear support vector machine achieves better accuracy than other techniques. Moreover, this research study investigates the importance of different factors of restaurant inspection and finds that inspection score and grade are significant features. The performance of the classifiers is measured by using the standard performance evaluation measures of accuracy, sensitivity and specificity.

Originality/value
This research uses a real-world data set of restaurant inspection that has, to the best of the authors’ knowledge, never been used previously by researchers. The findings are helpful in identifying the best restaurants and help finding the factors that are considered important in restaurant inspection. The results are also important in identifying possible biases in restaurant inspections by the authorities.
Conflict, caste and resolution: a quantitative analysis for Indian villages
Authors: Borooah Vani Kant , Tagat Anirudh , Mishra Vinod 
Published: October 2019

Purpose
The purpose of this paper is to provide a quantitative assessment of caste-based conflict in India. The data for this paper are from the Rural Economic and Demographic Survey (REDS) of 2006 encompassing 8,659 households in 242 villages in 18 Indian states.

Design/methodology/approach
Using these data, the authors examine two broad issues: the sources of conflict in rural India and the degree to which these sources contribute to caste-basted, as opposed to non-caste-based conflict; the sources of conflict resolution in rural India: are some conflict-resolving agencies more effective at dealing with caste-based conflicts and others more effective with non-caste-based conflicts?

Findings
There was a rise in caste-based conflict over the (approximate) period 1996-2006. There are several reasons for the rise in caste-based conflict but, in the main, is the rise in assertiveness of persons belonging to India’s lower castes. In terms of conflict resolution, panchayats and prominent individuals were important in resolving village conflicts: 69 per cent of caste-based, and 65 per cent of non-caste based, conflicts were resolved by one or the other of these two agents.

Originality/value
This is the first attempt, using econometric methodology, to study caste conflict at a village level in India.
Leadership style and teacher performance: mediating role of occupational perception
Authors: Abu Nasra Muhammed , Arar Khalid 
Published: October 2019

PurposeThe purpose of this paper is to develop a model in which leadership styles (transformational or transactional leadership) directly and indirectly (through occupation perception) affect teacher performance (in-role performance and organizational citizenship behavior (OCB)).Design/methodology/approachThe research hypothesis holds that the leadership style (transformational or transactional) has a direct and indirect effect on teacher performance (through occupation perception). These hypotheses have been tested on data collected from 630 Arab Israeli teachers.FindingsTeachers’ in-role performance increases as they perceive their principals’ leadership style as more transformational and less transactional. In addition, the results reveal that the effect of transformational principals’ leadership style on OCB is expressed only by indirect effect (through occupational perception).Originality/valueThe results of the study contribute to the understanding of the way leadership style and performance interact in schools, and the importance of teachers’ occupational perception in explaining this relationship. Future research should further investigate the teachers’ occupational perceptions and its effect on their performance as little research has been conducted to date.
The influence of team social media usage on individual knowledge sharing and job performance from a cross-level perspective
Authors: Cui Xiling , Huo Baofeng , Lei Yang , Zhou Qiang 
Published: October 2019

PurposeThe purpose of this paper is to examine how team social media usage (SMU) affects two types of knowledge sharing (KS), namely, in-role and extra-role KS, and then individual job performance. The study also examines the mediating effects of two types of KS and the main and moderating effects of team performance norms on individual job performance.Design/methodology/approachThis study applies the theory of communication visibility to develop a cross-level model and then validate it through a three-wave survey from 600 individuals in 120 teams. Hierarchical linear model is used to test the hypotheses.FindingsThe results suggest that team SMU improves team members’ in-role and extra-role KS, and thus enhances their individual job performance. The in-role and extra-role KS have partial mediating effects between team SMU and job performance. The results also show that team performance norms have a positive main effect on individual job performance, but negatively moderate the relationship between individual extra-role KS and job performance.Research limitations/implicationsThis study contributes to the operations management literature by examining the effects of team SMU from a multilevel perspective.Practical implicationsThe findings provide managers with ways to improve individual KS and job performance.Originality/valueThis study is one of the first to investigate the effects of team SMU on individual KS and job performance. It also identifies the two-sided effects of team performance norms.