bluuebunny/crossref_metadata_2025_split huggingface dataset:
Diagnostic performance of specific biomarkers for interstitial lung disease: a single center study
Authors: Maharjan Anu S. , Amjadi Sogol S. , Jaskowski Troy D. , La’ulu Sonia L. , Lebiedz-Odrobina Dorota , Frech Tracy M. , Tebo Anne E. 
Published: November 2024

Abstract

Objectives
This study aimed to determine the clinical significance of Krebs von den Lungen-6 (KL-6), surfactant proteins A (SP-A) and D (SP-D) in the evaluation and management of interstitial lung disease (ILD).

Methods
Serum KL-6, SP-A, SP-D levels were measured in 122 unique consecutive patients referred for connective tissue disease (CTD) associated ILD (CTD-ILD) autoantibodies and 120 “healthy” controls. Patients’ charts were retrospectively reviewed and categorized as ILD and non-ILD or CTD-ILD and other ILD. All biomarkers were evaluated for diagnosis and moderate vs. severe ILD based on high-resolution computed tomography (HRCT).

Results
ILD was diagnosed in 52 % (n=64) and non-ILD in 48 % (n=58). ILD patients were categorized as other ILD (61 %, n=39) or CTD-ILD (39 %, n=25). Patients with ILD had significantly elevated levels of SP-A (p<0.02), KL-6 or SP-D (both p<0.0001) when compared to those with non-ILD. The mean levels of all biomarkers were significantly elevated levels in the ILD compared to non-ILD group (p<0.0001). No significant difference in biomarker levels between CTD-ILD and other ILD groups (p≥0.900). Biomarkers had comparable specificities (89–93 %) however; sensitivities were variable at 75 , 77 and 17 % for KL-6, SP-D and SP-A, respectively. Combination of KL-6 and SP-D yielded comparable diagnostic accuracy to all biomarkers with median levels significantly higher in patients with severe vs. mild disease.

Conclusions
KL-6 and SP-D levels are elevated in ILD and therefore contribute to the diagnosis and risk stratification for patient management.
Solving the crisis with “do-it-yourself heroes”? The media coverage on pioneer communities, Covid-19, and technological solutionism
Authors: Asmuss Jeanette , Hepp Andreas , Lüpkes Julie , Schmitz Anne 
Published: November 2024

Abstract
Protective shields and medical devices produced in Makerspaces as well as the early detection of disease through self-measurement have been widely publicized in the media coverage of the Covid-19 pandemic. This article systematically examines this phenomenon by analyzing the coverage of the Maker and Quantified Self movements in Germany and the UK. Through a discourse analysis of (online) newspapers, the article demonstrates that during the pandemic the coverage of both pioneer communities was markedly positive. Makers were often portrayed as problem solvers, while Quantified Self members were depicted as seismographs of the pandemic. Overall, our analysis reveals an overarching narrative that constructs members of these groups as “do-it-yourself heroes” who respond to the Covid-19 pandemic through their experimental practices, promoting a form of technological solutionism.
A Schmidt–Nochka theorem for closed subschemes in subgeneral position
Authors: Heier Gordon , Levin Aaron 
Published: November 2024

Abstract
In previous work, the authors established a generalized version of Schmidt’s subspace theorem for closed subschemes in general position in terms of Seshadri constants.
We extend our theorem to weighted sums involving closed subschemes in subgeneral position, providing a joint generalization of Schmidt’s theorem with seminal inequalities of Nochka.
A key aspect of the proof is the use of a lower bound for Seshadri constants of intersections from algebraic geometry, as well as a generalized Chebyshev inequality.
As an application, we extend inequalities of Nochka and Ru–Wong from hyperplanes in 𝑚-subgeneral position to hypersurfaces in 𝑚-subgeneral position in projective space, proving a sharp result in dimensions 2 and 3, and coming within a factor of

3
/
2

3/2

of a sharp inequality in all dimensions.
We state analogous results in Nevanlinna theory generalizing the second main theorem and Nochka’s theorem (Cartan’s conjecture).
The asymptotic behavior for the Navier-Stokes-Voigt-Brinkman-Forchheimer equations with memory and Tresca friction in a thin domain
Authors: Dilmi Mohamed , Djenaihi Youcef , Dilmi Mourad , Boulaaras Salah , Benseridi Hamid 
Published: November 2024

Abstract
In this article, we investigate the behavior of weak solutions for the three-dimensional Navier-Stokes-Voigt-Brinkman-Forchheimer fluid model with memory and Tresca friction law within a thin domain. We analyze the asymptotic behavior as one dimension of the fluid domain approaches zero. We derive the limit problem and obtain the specific Reynolds equation, while also establishing the uniqueness of the limit velocity and pressure distributions.
Integration of Project-Based Learning in Science, Technology, Engineering, and Mathematics to Improve Students’ Biology Practical Skills in Higher Education: A Systematic Review
Authors: Megawati Ruth 
Published: November 2024

Abstract
Science, technology, engineering, and mathematics (STEM)-integrated project-based learning (PBL) is essential in contemporary education as it improves students’ advanced cognitive capacities, critical thinking aptitude, scientific literacy, and ecological awareness. This study aims to identify and highlight some research publications that examine STEM-integrated PBL to improve students’ biology practical skills in higher education. The author guided the systematic review process with the preferred reporting items for systematic reviews and meta-analyses diagram, ensuring a structured approach to article selection. The author selected 24 potential articles for the literature review based on certain inclusion criteria. The chosen articles emphasize the importance of evaluating STEM-integrated PBL to improve biology practicum skills among students in higher education, highlighting the need for quantitative methods such as descriptive surveys and experiments in research. The research article’s findings show a positive trend toward improving educational practices in biology through the integration of STEM in PBL, with a growing body of literature focusing on this area. The findings of this study offer valuable insights for educators to improve students’ biology practical skills in higher education.
Comparison between thermal models across the Middle Magdalena Valley, Eastern Cordillera, and Eastern Llanos basins in Colombia
Authors: Bermúdez Mauricio A. , Moreno Gleubis Belén Silveira , Fernández Andrea Gómez , González Natalia Urrea , Chaparro Lady Alejandra Barrera 
Published: November 2024

Abstract
In this research, we compared thermochronological and traditional one-dimensional thermal models across the Middle Magdalena Valley (MMV), Eastern Cordillera, and Eastern Llanos Basins in Colombia. These models allow us to relate cooling/heating histories to exhumation events, subsidence, fault activities, and fluid flow. The Eastern Cordillera and Eastern Llanos Basins are discriminated as prospective zones for hydrocarbon (HC) generation. The De Armas Syncline at the MMV basin shows high thermal maturity (127°C), describing rocks completely depleted in terms of HC generation. The eastern zone of this syncline is buried until it reaches temperatures above 150°C. The contrast between thermal models in the Eastern Cordillera basin suggests a possible sediment supply scenario from the west to the east of the Soapaga Fault. In the Eastern Llanos basin, the thermal histories between both models explain the latest uplift and sediment supply processes from the hinterland zone of the Eastern Cordillera to the foothill zone of the Eastern Llanos basin. In terms of thermal evolution, the three basins are different, reaching different levels of burial and HC maturity. However, in terms of cooling events related to exhumation, the basins have similarities as they are controlled by the mountain building of the Eastern Cordillera of Colombia.
Thermal conductivity evaluation of magnetized non-Newtonian nanofluid and dusty particles with thermal radiation
Authors: Hussain Syed Modassir , Khan Umair , Obalalu Adebowale Martins , Zaib Aurang 
Published: November 2024

Abstract
The thermal conductivity of nanofluids (NFs) has emerged as a critical area of research due to its potential to enhance heat transfer in various industrial applications. Non-Newtonian NFs, in particular, exhibit unique flow characteristics under the influence of magnetic fields, making them suitable for systems requiring precise control of fluid dynamics, such as cooling systems in electronics and energy sectors. Owing to its usage, this article presents the magneto-Marangoni convective flow for fluid (phase-I), particle (phase-II), and propagation in tangent hyperbolic NF (copper–ethanol) containing maximum cell swimming speed. This study aims to evaluate the thermal conductivity of magnetized non-Newtonian NFs mixed with dusty particles in the presence of thermal radiation, exploring how magnetic fields and particle interactions affect overall thermal performance. The Gegenbauer wavelet collocation-based scheme was utilized to solve the model and investigate physical attributes such as plate friction, Nusselt number, Sherwood number, and mass flux. The results indicate that the species reaction field is increased by activation energy, whereas it is reduced by chemical reaction. Also, increasing values of thermal radiation tend to improve the heat distribution.
40 Gb/s RoFSO communication system under turbulent channel link for 5G applications
Authors: Mohammed Tahani J. , Ali Mazin Ali A. 
Published: November 2024

Abstract
The present study involves an examination of a communication system known as radio over free space optics (RoFSO), which was designed using Optisystem ver. 20. The main purpose of this inquiry is to analyze the transmission of data at a rate of 40 Gb/s over a link distance of 2 km. The achievement was attained by the utilization of four transmission channels, each of which has the capability to send data at a rate of 10 Gb/s. The system under consideration was evaluated through varying degrees of turbulence. Two scintillation models, log-normal and gamma–gamma, were used to evaluate the proposed communication performance and include evaluating the behavior of specific wavelengths (193.1, 193.2, 193.3, and 193.4 THz) in transmitting data. This evaluation is achieved by the metrics Q-factor, bit error rate (BER), and log BER. The suggested system’s data-transfer performance improved up to a distance of 1.75 km when the scintillation (L-N) model was applied, whereas it was limited to 0.75 km when the (G-G) model was imposed. Furthermore, it is noticed that the wavelength (193.1 THz) is distinct in data transfer across the two models, followed by the wavelength (193.4 THz). RoFSO is an emerging network architecture that holds significant potential for fulfilling the envisioned requirements for the advancement of 5G systems.
Different optical fiber hybrid repeater amplifiers arrangement for optical losses and optical dispersion management in the presence of modulation code schemes
Authors: Prabu Ramachandran Thandaiah , Lingaraj Vanitha , Gajendran Bhavani , Balakrishnan Balamuralitharan , Balashanmugam Thiyaneswaran , Dorairajan Nithya , Adel Marian Habbib 
Published: November 2024

Abstract
This paper highlights the different optical fiber hybrid repeater amplifiers arrangement for optical losses and optical dispersion management in the presence of modulation code schemes. The light signal power is measured and clarified with/without any amplification versus fiber channel length with 1,300 and 1,550 nm wavelength based on various modulation schemes. Electrical output power after receiver is clarified without amplification and with various amplification techniques against fiber channel length with second and third wavelength based on on-off keying modulation code scheme. The quality factor and BER are measured after receiver against transmission data rates without amplification and with various amplification techniques against 300 km fiber channel length with 1,300 nm wavelength based different modulation code schemes.
Elbow injuries in overhead throwing athletes: clinical evaluation, treatment, and osteopathic considerations
Authors: King Benjamin W. , Raum George M. , De Luigi Arthur J. , Bowers Robert L. 
Published: November 2024

Abstract
Injury to the elbow is very common in the throwing athlete and can potentially lead to long absences from play and, in the most severe scenarios, medical retirement. The throwing motion is a highly complex series of movements through the entire kinetic chain that results in very high angular velocities and valgus forces at the elbow joint. The repetitive nature of overhead throwing in combination with the high levels of accumulated force at the elbow puts both pediatric and adult athletes at risk of both acute and chronic overuse injuries of the elbow. This review provides an update on common injuries in the throwing athlete and covers clinical presentation, diagnosis, and treatment of these injuries.
Assessment of quality of life in families affected by maple syrup urine disease: a cross sectional study
Authors: Magdy Rofaida M. , Dolins Karen Reznik , Nagdy Hanan , Ali Tasneem Mohammed , Elabd Heba S. , Hassan Mohammad Ahmad 
Published: November 2024

Abstract

Objectives
Maple syrup urine disease (MSUD) is considered one of the intoxication-type inborn errors of metabolism (IT-IEM). Patients with MSUD are afflicted with a chronic illness, and the disease and its management have both physical and psychological consequences for the patients and their families. The aim of this study was to assess the quality of life (QoL) and its main determining factors for patients with MSUD and their families under follow-up in Sohag University Hospital.

Methods
Parents of 36 patients with MSUD participated in a questionnaire translated into Arabic to assess their QoL. Subsequently, a file review was conducted to identify any key factors that could potentially influence the parents’ QoL.

Results
The results of the study indicated that 27 (75 %) of the MSUD patients exhibited poor QoL, while only 9 (25 %) patients reported good QoL across all studied aspects. Significant differences were observed between the two groups in terms of the disease onset, whether acute or asymptomatic (diagnosed before acute metabolic decompensation) (p=0.001) and the type of screening employed (p=0.007).

Conclusions
There is a paucity of data on the QoL of pediatric patients with IT-IEM, including MSUD. The methodological approaches and assessment instruments utilized in existing studies are inconsistent. Identifying the factors that affect QoL would be beneficial for improving patient care, evaluating outcomes and treatments, and planning effective social and psychological interventions to enhance the patients’ QoL.
Prevalence of fragile X syndrome in South Asia, and importance of diagnosis
Authors: Fazna Aminath , Hagerman Randi Jenssen 
Published: November 2024

Abstract
Fragile X syndrome (FXS) is a genetic disorder caused by a mutation in the FMR1 gene on the X chromosome, leading to a range of developmental and intellectual disabilities. FXS is characterized by intellectual disability, behavior challenges, and distinct physical features such as an elongated face, large ears, and hyperflexible joints; FXS remains the most common inherited cause of intellectual disability. Behavioral manifestations often include attention deficits, hyperactivity, anxiety, and features of autism spectrum disorder. The prevalence of FXS in the South Asian population is not well-documented, but existing studies suggest it may be comparable to global prevalence rates, which are approximately 1 in 4,000 males and 1 in 8,000 females. Accurate diagnosis of FXS in South Asians is crucial due to the implications for early intervention and treatment, which can significantly improve the quality of life and developmental outcomes for affected individuals. Early diagnosis also facilitates genetic counselling and family planning, helping to reduce the risk of recurrence in families. Increased awareness and screening in South Asian communities are essential to address the diagnostic gap and ensure timely support for individuals with FXS or disorders associated with the premutation of FMR1.
Considerations for electromagnetic simulations for a quantitative correlation of optical spectroscopy and electron tomography of plasmonic nanoparticles
Authors: Dieperink Mees , Skorikov Alexander , Claes Nathalie , Bals Sara , Albrecht Wiebke 
Published: November 2024

Abstract
The optical cross sections of plasmonic nanoparticles are intricately linked to their morphologies. Accurately capturing this link could allow determination of particles’ shapes from their optical cross sections alone. Electromagnetic simulations bridge morphology and optical properties, provided they are sufficiently accurate. This study examines key factors affecting simulation precision, comparing common methods and detailing the impacts of meshing accuracy, dielectric function selection, and substrate inclusion within the boundary element method. To support the method’s complex parameterization, we develop a workflow incorporating reconstruction, meshing, and mesh simplification, to enable the use of electron tomography data. We analyze how choices of reconstruction algorithm and image segmentation affect simulated optical cross sections, relating these to shape errors minimized during data processing. Optimal results are obtained using the total variation minimization (TVM) reconstruction method with Otsu thresholding and light smoothing, ensuring reliable, watertight surface meshes through the marching cubes algorithm, even for complex shapes.
Hydrothermal synthesis and crystal structure of catena-poly[(1,10-phenanthroline-κ
2
N,N′)-bis(μ
2-nitroisophthalato-κ
3
O,O′:O″)nickel(II)], C20H13NiN3O7
Authors: Wen-Jie Bi , Dong Xie , Xing-ming Hu , Hu Chen , He-dong Bian 
Published: November 2024

Abstract
C20H13NiN3O7; triclinic, P1̄ (no. 2), a = 8.329(7) Å, b = 8.726(8) Å, c = 13.300(12) Å, α = 85.948(14)°, β = 75.509(14)°, γ = 72.258(13)°, V = 891.3(13) Å3, Z = 2, R

gt
(F) = 0.0373, wR

ref
(F
2) = 0.1007, T = 296(2) K.
Comparing classic time series models and state-of-the-art time series neural networks for forecasting as-fired liquor properties
Authors: Ng Jerry , Lawryshyn Yuri , DeMartini Nikolai 
Published: November 2024

Abstract
The properties of as-fired black liquor dictate kraft recovery boiler operation. If these properties could be forecasted, operations could be adjusted to optimize boiler performance. Here, we compare the performances of classic time series models and two state-of-the-art time series neural networks for forecasting as-fired liquor heating value, viscosity, and boiling point rise at a Canadian mill. Additionally, we show that, like classic time series models, autoregressive neural networks can be regarded as functions of unknown disturbances, which is useful in comparing model complexities. Our results show that classic time series models can accurately forecast as-fired liquor properties and that classic time series models perform comparably to state-of-the-art time series neural networks. We suspect this is due to the high autocorrelation of mill data that results from frequent measurements relative to long residence times. This autocorrelation is suspected to attenuate the cross-correlations between upstream disturbances and as-fired liquor properties. As a result, neural networks, which are useful for accommodating non-linear cross-correlations and dynamics, struggle to outperform classic time series models and may not always be appropriate for forecasting chemical process parameters.
Zur Bedeutung der Leitlinienerstellung für den Öffentlichen Gesundheitsdienst zur effizienten Überwachung der Trinkwasserversorgung für die Bevölkerung
Authors: Exner Martin , Junge Daniel , Jakubowski Elke 
Published: November 2024

Zusammenfassung
Die Trinkwasserüberwachung ist eine originäre Aufgabe des Öffentlichen Gesundheitsdienst (ÖGD). Sie dient dem Schutz der öffentlichen Gesundheit. Für diese Aufgabe sind internationale und nationale Normen und Handlungsempfehlungen etabliert. Zugleich bestehen Ausgestaltungslücken und es fehlen Überwachungskapazitäten im ÖGD. Lücken zu schließen, und Kompetenzen und Kapazitäten für die Trinkwasserüberwachung im ÖGD zu stärken ist in Anbetracht aktueller ökologischer und geopolitischer Herausforderungen besonders dringend.
Evidenzbasierung im Infektionsschutz
Authors: Harder Thomas , Bornhofen Bernhard , Rexroth Ute 
Published: November 2024

Zusammenfassung
Wie das Beispiel der STIKO-Empfehlungen zeigt, sichert ein evidenzbasiertes, transparentes und partizipatives Vorgehen bei der Entwicklung von Empfehlungen die Qualität der Maßnahmen im Infektionsschutz und erhöht deren Akzeptanz bei den Zielgruppen. Neben zeit- und ressourcensparenden Methoden wie Rapid Reviews und KI-Anwendungen braucht der ÖGD jedoch strukturelle Ertüchtigung, um im Infektionsschutz sein wissenschaftliches Selbstverständnis und Evidenzbasierung noch breiter umzusetzen.
Evidenzbasierung im Zahnärztlichen Dienst
Authors: Schäfer Michael , Gottstein Ilka 
Published: November 2024

Zusammenfassung
Die Zahnärztlichen Dienste in den Gesundheitsämtern arbeiten auf der Basis der existierenden Gesetzgebung. Die Zahnärztinnen und Zahnärzte des Öffentlichen Gesundheitsdienstes bringen sich in die Erstellung der Leitlinien ein, die eine wesentliche Basis ihrer Arbeit darstellen. Maßnahmen zur Qualitätssicherung wurden geschaffen. Evidenzbasiertes Handeln wird zur Bewältigung der Probleme in der Mundgesundheit vordringlicher. Eine Anbindung an eine Bundesinstitution wäre eine weitere Maßnahme.
Das Verbundvorhaben RESILIENT als Beispiel für Evidenzbasierung im Öffentlichen Gesundheitsdienst
Authors: Trautmann Freya , Galante-Gottschalk Annette , Schade Manuela , Zscheppang Anja 
Published: November 2024

Zusammenfassung
Die kommunale Gesundheitsberichterstattung stellt eine wichtige Grundlage für eine bedarfsorientierte und evidenzbasierte Gesundheitsplanung dar, allerdings fehlt es bisher an wichtigen Voraussetzungen. Das Verbundvorhaben RESILIENT erprobt einen Ansatz zur Verknüpfung von Gesundheits-, Umwelt- und Sozialdaten auf kleinräumiger Ebene, wobei Daten der gesetzlichen Krankenversicherung eine zentrale Rolle zur Abbildung der gesundheitlichen Lage darstellen. Die Umsetzung ist stadtspezifisch mit verschiedenen Herausforderungen verbunden.
Green synthesis of gold nanoparticles and their emerging applications in cancer imaging and therapy: a review
Authors: Ali Dheyab Mohammed , Tang Jia Hui , Abdul Aziz Azlan , Hussein Nowfal Shaymaa , Jameel Mahmood S. , Alrosan Mohammad , Oladzadabbasabadi Nazila , Ghasemlou Mehran 
Published: November 2024

Abstract
The green and eco-friendly synthesis of gold nanoparticles (AuNPs) from renewable resources such as plants, algae, fungi, and bacteria has recently gained interest due to its use of sustainable feedstocks. This review presents an in-depth exploration of AuNP synthesis methods and their applications in cancer imaging and therapy. We examine the mechanisms behind various physical and chemical techniques used to synthesize AuNPs, with a special focus on the unique biomedical applications of green-synthesized AuNPs in diagnostic and therapeutic platforms, such as imaging and targeted therapy. Although promising, green synthesis of AuNPs faces challenges, including variability in particle size, limitations in morphology control, and scalability issues, which need to be addressed to fully harness their potential. This review also demonstrates that AuNPs can be loaded with anticancer agents to create targeted drug delivery vehicles for tumor treatment. As nanotechnology drives revolutionary advances in healthcare, AuNPs offer a promising toolkit for medical progress. However, a fundamental understanding of AuNPs and rigorous risk assessments in diagnostics, imaging, and therapeutic applications are essential to enable their safe and effective use in clinical settings.