bluuebunny/crossref_metadata_2025_split huggingface dataset:
Docking Assisted Prediction and Biological Evaluation of Sideritis L. Components with PTP1b Inhibitory Action and Probable Anti-Diabetic Properties
Authors: Eleftheriou Phaedra , Therianou Ekaterini , Lazari Diamanto , Dirnali Stavroula , Micha Anna 
Published: February 2019

Background:
The main characteristic of Diabetes type II is the impaired activation of intracellular
mechanisms triggered by the action of insulin. PTP1b is a Protein Tyrosine Phosphatase that
dephosphorylates insulin receptor causing its desensitization. Since inhibition of PTP1b may prolong
insulin receptor activity, PTP1b has become a drug target for the treatment of Diabetes II. Although a
number of inhibitors have been synthesized during the last decades, the research still continues for the
development of more effective and selective compounds. Moreover, several constituents of plants and
edible algae with PTP1b inhibitory action have been found, adding this extra activity at the pallet of
properties of the specific natural products.

Objective:
Sideritis L. (Lamiaceae) is a herbal plant growing around the Mediterranean sea which is included
in the Mediterranean diet for centuries. The present study is the continuation of a previous work
where the antioxidant and anti-inflammatory activities of the components of Sideritis L. were evaluated
and aimed to investigate the potential of some sideritis’s components to act as PTP1b inhibitors, thus
exhibiting the beneficial effect in the treatment of diabetes II.

Methods:
Docking analysis was done to predict PTP1b inhibitory action. Human recombinant PTP1b
enzyme was used for the evaluation of the PTP1b inhibitory action, while inhibition of the human LAR
and human T-cell PTP was tested for the estimation of the selectivity of the compounds.

Conclusion:
Docking analysis effectively predicted inhibition and mode of inhibitory action. According
to the experimental results, four of the components exhibited PTP1b inhibitory action. The most active
ones were acetoside, which acted as a competitive inhibitor, with an IC50 of 4 µM and lavandufolioside,
which acted as an uncompetitive inhibitor, with an IC50 of 9.3 µM. All four compounds exhibited increased
selectivity against PTP1b.
Drug Overdose-Induced Coma Blisters: Pathophysiology and Clinical and Forensic Diagnosis
Authors: Dinis-Oliveira Ricardo J. 
Published: February 2019

Background:Coma blisters or coma bullae are bullous lesions that have been associated with cases of drug overdose-induced coma. Previous history of suicide attempt by administering benzodiazepines, barbiturates, ethanol, antipsychotics, antidepressants or opioids have been particularly implicated. Patients may present also painful deep skin and soft tissue involvement, edema and functional impairment. The pathophysiology remains unknown and lesions are usually self-limited and typically resolve without scarring.Objective:This work aims to fully review the state of the art regarding the causes pathophysiology, diagnosis and treatment of drug overdose-induced coma blisters.Conclusion:Coma blisters are a benign, self-limiting condition that should be suspected in patients who develop pressure blisters several hours after an altered state of consciousness.
Matching-adjusted indirect comparison: secukinumab versus infliximab in biologic-naive patients with psoriatic arthritis
Authors: Strand Vibeke , McInnes Iain , Mease Philip , Nash Peter , Thom Howard , Kalyvas Chrysostomos , Hunger Matthias , Gandhi Kunal , Pricop Luminita , Jugl Steffen , Choy Ernest 
Published: February 2019

Aim:To compare secukinumab with infliximab in biologic-naive patients with psoriatic arthritis using matching-adjusted indirect comparison.Patients & methods:Individual patient baseline data for secukinumab were matched to published aggregate data for infliximab by key baseline characteristics, with matching weights determined by logistic regression, and used to recalculate American College of Rheumatology (ACR) responses for secukinumab, for comparison with infliximab.Results:There were no differences in outcomes between secukinumab and infliximab at weeks 6/8 and 14/16. At weeks 24 and 54/52, ACR 20 responses were higher with secukinumab 150 mg than infliximab. At week 54/52, ACR 20/50 responses were higher for secukinumab 300 mg than infliximab.Conclusion:In the mid to long term, patients receiving secukinumab were more likely to achieve ACR 20/50 responses than those receiving infliximab.
DIREITO, ESTADO E A GOVERNANÇA GLOBAL: UMA ANALISE CRÍTICA ANTE A CONFIGURAÇÃO DE UMA SOCIEDADE INTERNACIONAL COMPLEXA
Authors: Antunes de Miranda José Antunes , Barcelos Corrêa Janaína 
Published: February 2019

A globalização trouxe novos atores e níveis de produção jurídica questionando a soberania do Estado, enfraquecendo a força normativa das Constituições e promovendo a governança global. O objetivo desse artigo é analisar de forma crítica o papel do direito frente ao atual processo de globalização em um mundo cada vez mais absorvido por práticas de governança global onde se observa casa vez mais a diminuição da aplicação de princípios tipicamente de matriz constitucional na esfera jurídica internacional. Realizou-se um estudo, com base em pesquisa bibliográfica procurando identificar a discussão sobre a evolução normativa das ações de governança global. Concluímos que a coexistência de diferentes atores e instituições formais de governança não significa que o estado-nação e as instituições intergovernamentais tenham perdido importância. O Estado nação é uma constituição histórica, mas mutável, e o monopólio, o exercício da autoridade, não pode ser a ele exclusivo em um mundo de características cada vez mais complexas e interdependentes.Palavras chaves: Globalização. Soberania. Estado-Nação. Constituições. Governança.
WOMEN'S EXISTENCE IN CHRISTINA ROSSETTI'S 'BRIDE SONG' POEM (EKSISTENSI PEREMPUAN DALAM PUISI 'BRIDE SONG' KARYA CHRISTINA ROSSETTI)
Authors: Winarti Winarti 
Published: February 2019

This article aims at describing women existence as reflected on Bride Song poem written by Christina Rossseti. Rossettiâ€™s view on womenâ€™s lives was inspired much by her awareness toward the their conditions in Victorianâ€™s era. In the meantime, women were shaped to be an individuals who fulfill the ideal standard as preferred by men. By Bride Song, Rosetti tried to break patriarchal domination toward women. She wanted to turn back the existence equivalence between men and women based on human rights. She also attemped to open the worldâ€™s perspective to accept womenâ€™s existence as important as menâ€™s and not just a binary opposition of it. Womenâ€™s existence in Bride Song is not only a struggle against menâ€™s domination in Victorian era, but it alsoÂ has relevance with contemporary issues on womenâ€™s struggle to show their existence in this modern era.
ARISTA : Application of Reporting Information System at FTK Undiksha
Authors: Anggisavitri Kade Arista 
Published: February 2019

Penelitian ini bertujuan: Membuat rancang bangun dan mengembangkan ARISTA (Application of Reporting Informastion System FTK Undiksha); mengetahui respon sivitas akademika FTK terhadap ARISTA (Application of Reporting Informas-tion System at FTK Undiksha). Untuk memberikan pelayanan yang baik bagi civitas akademikanya, FTK memberikan kesempatan kepada sivitasnya untuk memberikan masukan baik kritik maupun saran terkait pelayan yang diberikan. Aplikasi ARISTA akan mewadahi semua keluhan baik kritik maupun saran yang berhubungan dengan pihak jurusan maupun fakultas. Aplikasi ini membagi cakupan permasalahan menjadi 2 yaitu, pengaduan ke jurusan atau pengaduan ke fakultas. Jenis penelitian ini adalah penelitian pengembangan dengan model Analysis, Design, Development, Implementation, and Evaluation (ADDIE).Implementasi penelitian ini diterapkan dengan menggunakan framework Re-act-Native pada aplikasi mobile dan menggunakan bahasa pemrograman PHP dengan bantuan framework Laravel pada aplikasi web. Untuk proses pengujian, dilakukan lima (5) tahap proses pengujian yaitu: Uji blackbox untuk mengetahui apakah seluruh fungsional perangkat lunak sudah sesuai dan hasilnya sebesar 100% baik; uji whitebox yang menyatakan bahwa implementasi source code sesuai dan tanpa error; uji pengalaman pengguna menggunakan metode UEQ untuk mengetahui pengalaman pengguna setelah mengunakan aplikasi ARISTA; uji compatibility yang menyatakan aplikasi ARISTA bisa digunakan pada perangkat dengan merek dan sistem operasi Android yang berbeda; uji keamanan yang dilakukan dengan SQL Injection sebanyak 4 kali menyatakan bahwa aplikasi ARISTA aman. Kata kunci: Aplikasi Mobile, Pengaduan, FTK, Undiksha, React-Native
Enhancement of Some Mechanical Properties of White Cement Mortar by Adding Nanoparticles of Zirconium Oxide
Authors: Al-kamal Ahmed K. , Marhoon Ismail Ibrahim , Salman Ali A. , Muhammad Ahmed K. 
Published: February 2019

This paper will study mortar compressive strength (fc) and flexural strength (fr) by cement replacement which is partial with the particles of Nano-Zr2O3. Zr2O3nanoparticles are used as well as using average diameter of 35 nm with four various contents by weight of cement (0.25%, 0.75%, 1.25% and 1.75%). The (fc) and (fr) tests were performed after the process of curing at the 28-days which is the standard age. The preparation of mortar of Nano-cement was done by using the ratio of cement-sand by weight which is 1:3 with the ratio of water-binder materials (w/b ratio) as 0.5. The results demonstrated that the (fc) and (fr) of the mortars of cement with Zr2O3were registered higher than cement mortar that is pure. The ultimate Nano-cement mortar strength was obtained at 1.25% of the replacement of cement. The improvement in (fc) and (fr) were 15.6 % and 18.4% in a respective way at 28 days.
Teknologi Komputer dan Proses Kreatif Musik Menuju Revitalisasi Pembelajaran Seni Musik
Authors: Wahyu Widodo Tri 
Published: February 2019

The impact of computer technology advancement in current music education, as well as musical life in general, is undoubted cannot be avoided. Modern music software has given a great contribution to musical creativity so that computer technology can help tertiary music education process to be much better.Keywords: Computer technology, music education, musical creativity
Fast Coordination of Power Electronic Converters for Energy Routing in Shipboard Power Systems
Authors: Ginn III H L , Bakos J D , Flinstone Fred , Benigni A 
Published: February 2019

A long-term goal of future naval shipboard power systems is the ability to manage energy flow with sufficient flexibility to accommodate future platform requirements such as, better survivability, continuity, and support of pulsed and other demanding loads. To attain this vision of shipboard energy management, shipboard power and energy management systems must coordinate operation of all major components in real-time. The primary components of a shipboard power system are the generators, energy storage modules, and increasingly power electronics that interface those sources and main load centers to the system. Flexible management of energy flow throughout shipboard distribution systems can be realized by automated coordination of multiple power electronic converters along with storage and generation systems. Use of power converters in power distribution systems has continuously increased due to continued development of the power electronics building blocks (PEBB) concept which reduces cost and increasing reliability of converters. Recent developments in SiC power devices are yielding PEBBs with far greater switching frequencies than Si based devices resulting in an order of magnitude reduction of the time scales as compared to converter systems utilizing conventional IGBT based PEBBs. In addition there have also been advancements in highly modularized converter systems with hundreds of PEBBs such as the Modular Multilevel Converter. Both of those trends have resulted in the continued evolution of the Universal Controller Architecture which attempts to standardize control interfaces for modular power electronic systems. Further development of interface definitions and increasing communication and computational capabilities of new FPGA based controllers provides opportunities beyond simply supporting SiC PEBBs. Fast control coordination across the system using an appropriate communication architecture provides a degree of energy management not previously realizable in shipboard power systems. The paper will present recent research results in networked control architectures for power electronic converter coordination and control. It will demonstrate that current FPGA and gigabit speed serial communication technologies allow for a very high degree of energy flow control.
No process for initiative
Authors: Parkes G J 
Published: February 2019

Throughout naval aviation engineering history, processes have continually developed and improved safety, especially with rapidly evolving complex aircraft systems. With more processes to follow, technicians will become more reliant on those processes. The post Hadden-Cave era has led to increased understanding of accountability, thereby diminishing initiative or the application of engineering principles to solve real life engineering problems. High level policy and accountability rhetoric have cascaded throughout engineering management to engineering technicians, with the warning ‘do not deviate from process’ from fear air safety may be compromised. This, coupled with the perceived threat of consequence to the individual should compliance be ignored, leads to a culture of process rather than a culture of lateral thought around complex engineering issues. Consequently, naval engineers feel unable to innovate or improvise practical solutions to problems despite engineers understanding the need to maintain air safety. As a war-fighting organisation which extends to disaster relief operations or damage control at sea, the supervisor/team leader may find themselves without a process and potentially unable to respond with confidence to the situation at hand. A key attribute of a Petty Officer is initiative; as reliance on process increases and reliance on effective intelligence decreases, are the Royal Navy limiting their future leaders? Attitudes and competence take time to change and develop; there is an increasing risk that the naval engineer of the future fails to think around problems and it is imperative that we encourage and develop initiative in naval aviation engineers.
Mujeres en prisiones españolas. Violencia, conflictos y acciones para la paz
Authors: Chávez Torres Martha , Añaños Bedriñana Fanny Tania 
Published: February 2019

Las manifestaciones de violencia y de conflictos aquí analizados, se centran en prisiones españolas. Se aplicaron 538 cuestionarios a mujeres, clasificadas en segundo y tercer grado de cumplimiento de la pena, repartidas en cárceles de once Comunidades Autónomas en los regímenes de vida ordinario y abierto. El objetivo es mostrar la interdependencia entre violencia y conflicto, las manifestaciones en prisión de esta diada y las soluciones encontradas por parte de las mujeres y del personal penitenciario; acciones que conducen a una paz artificiosa y tensa. Por último se plantea la trascendencia social de una educación penitenciaria en la cultura de paz para la transformación de los conflictos.
Bilingüismo de indígenas migrantes y desplazamiento de idiomas autóctonos en León, Guanajuato
Authors: Schnuchel Sophia 
Published: February 2019

El presente artículo trata sobre el contacto del español con seis idiomas indígenas en el contexto de la migración interna en la ciudad de León, Guanajuato. Se analizan los conocimientos lingüísticos de 67 personas indígenas, las cuales pertenecen a seis etnias, y su grado de multilingüismo. Se muestra que la competencia oral en los idiomas indígenas es mejor que la competencia escrita en estos idiomas vernáculos. Además, se observa que los adultos tienen mejores conocimientos de los idiomas indígenas y problemas con el español, mientras que la mayoría de los niños son bilingües y dominan el español mucho mejor que sus padres. También se analizan los contextos en los cuales se usan los idiomas. Se puede constatar que se presenta una situación de diglosia entre los indígenas que viven en León.
Bertha Dimas Huacuz y Grupo Tsinajpiriicha. Sïpiaata tsinajpekua. Plantas y prácticas medicinales de los p’urhépecha / Sïpiaata ka tsinajpekua p’urhepecheeri. Morelia: Secretaría de Cultura, PACMyC, Dirección General de Culturas Populares-Unidad Regional Michoacán, 2018, 149 p. ISBN en trámite
Authors: Meneses Eternod Sue 
Published: February 2019

Compendio, en versión bilingüe español-p'urhepecha, sobre cuarenta plantas medicinales de la región con indicaciones sobre sus usos, sus características morfológicas, los espacios físicos en donde comúnmente se encuentra, sus partes útiles, además de su preparación, modo de empleo y sus contraindicaciones.
INCIDENCE OF POWDERY MILDEW ON CUCURBIT PLANTS IN KATSINA, NIGERIA
Authors: Labo Abubakar  Umar , Gufran Ahmad Abrar Ahmad Khan, 
Published: February 2019

Present paper deals with the study of powdery mildew incidence on different cucurbits in Katsina city (Barhim Estate, Kofar Durbi, Kofar Sauri, Kofar Marusa and Low Cost), Nigeria. The finding shows that the areas infested with powdery mildew is one of the important disease of cucurbits. The Sphaerotheca fuliginea was identified to be the causal organism present on all observed cucurbits in the study. Highest frequency of disease was found in Kofar Sauri(79%) fallowed by Kofar Marusa (68%), Kofar Durbi (66%), Barhim Estate (65%) and the lowest frequency of occurrence of disease was found in Low Cost (55%).The intensity of the disease was moderate to severe in general but it was high in many fields, the area-wise variation was also noticed. On vegetables, the highest frequency of occurrence of powdery mildew disease was observed on L. cylindrica (76.4%) followed by C. moschata (60%), C. sativus (59.3%), C. vulgaris (53.9%) and lowest was found on C. melo (44.4%). The highest intensity of disease was found on C. moschata, followed by L. cylindrica, C. sativus, C. vulgaris and C. melo.
Numerical solution of modified regularized long wave equation by using cubic trigonometric B-spline functions
Authors: ZORŞAHİN GÖRGÜLÜ Melis , IRK Dursun 
Published: February 2019

In this study, the Modified Regularized Long Wave (MRLW) equation is solved numerically. The method used for the numerical solution of MRLW equation includes the space discretization with the Galerkin finite element method based on cubic trigonometric B-spline, and also the time discretization with the Crank-Nicolson method. We tried to obtain a more accurate method with the help of trigonometric B-spline for the numerical solution of the MRLW equation than the existing numerical methods in the first test problem. Then, the interaction problem of the two positive solitary waves of the MRLW equation is considered, and the conservation constants are compared with the existing ones to see the correctness of the method.
Kendali Logika Fuzzy pada Sistem Electronic Control Unit (ECU) Air Conditioner Mobil
Authors: Fahmizal Fahmizal , Orlando Tommy Richard , Murti Budi Bayu , Budiyanto Maun , Mayub Afrizal 
Published: February 2019

<p>Makalah ini memaparkan perancangan kendali logika <em>fuzzy</em> pada sistem <em>electronic control unit </em>(ECU)<em> </em><em>air condition</em><em>er </em>mobil. Salah satu kendala pada ECU mobil adalah kerusakan pada sistem <em>air conditio</em><em>ner</em>. Bila ini terjadi umumnya pengguna mobil mengganti sistem ECU secara keseluruhan. Namun pada makalah ini, penulis meracang sistem ECU yang secara khusus digunakan untuk sistem <em>air conditioner</em> mobil. Sistem yang dirancang menggunakan sensor DS18B20 <em>waterproof</em> untuk mendeteksi suhu <em>evaporator</em> mobil. Selanjutnya, nilai suhu tersebut digunakan sebagai masukan logika <em>fuzzy</em> yang terdiri dari pembacaan suhu sekarang dan suhu terakhir dalam mengatur kecepatan putar kipas motor DC atau <em>fan exhausting</em> dan waktu <em>switching</em> <em>magnetic</em> <em>clutch compressor</em> menyala. Hubungan relasi masukan <em>fuzzy</em> diselesaikan dengan aturan Mamdani dan keluaran dari logika <em>fuzzy</em> diselesaikan dengan metode <em>weight average</em> (WA). Dari hasil pengujian diperoleh bahwa kendali logika <em>fuzzy</em> yang diaplikasikan pada rancangan sistem <em>air conditio</em><em>ner</em> mampu mengendalikan kecepatan <em>fan exhausting</em> secara halus dan responsif.</p><p><em><strong>Abstract</strong></em></p><p><em>This paper describes the design of fuzzy logic controls in the system of electronic control unit (ECU) of car air conditioner. One obstacle in the car ECU is damage to the air conditioner system. If this happens generally car users change the whole ECU system. But in this paper, the authors form the ECU system which is specifically used for car air conditioner systems. The system is designed using a DS18B20 waterproof sensor to detect the temperature of the car's evaporator. Furthermore, the temperature value is used as a fuzzy logic input consisting of reading the current temperature and the last temperature in adjusting the rotating speed of the DC motor fan or exhausting fan and when the switching magnetic clutch compressor is on. Completion of fuzzy input relations is solved using Mamdani rules and the output of fuzzy logic is solved using the weight average (WA) method. From the test results it was found that the fuzzy logic control applied to the design of the air conditioner system was able to control the speed of the exhausting fan in a smooth and responsive manner.</em></p><p><strong><br /></strong></p><p> </p>