bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pengaruh H2SO4 pada PVA yang Dimodifikasi pada Campuran Biomassa Tongkol Jagung-Bulu Ayam sebagai Adsorben Campuran Logam Pb2+ dan Cu2+
Authors: Fatmawati Sitta Noor , Hastuti Rum , Haris Abdul 
Published: November 2018

Penelitian tentang pengaruh H2SO4 pada PVA yang dimodifikasi pada campuran biomassa dari tongkol jagung - bulu ayam sebagai adsorben untuk campuran ion Pb2+ dan Cu2+ telah dilakukan. Tujuan dari penelitian ini adalah memperoleh data mengenai pembuatan adsorben dari tongkol jagung - bulu ayam sebelum dimodifikasi PVA dengan asam sulfat A1 dan setelah modifikasi A2. Serta untuk menentukan kapasitas adsorpsi, konstanta kesetimbangan adsorpsi, energi adsorpsi dan pengaruh kompetisi campuran ion Pb2+ dan Cu2+. Adsorben yang dihasilkan selanjutnya dikarakterisasi menggunakan spektroskopi FTIR dan BET. Hasil penelitian menunjukkan bahwa penambahan PVA dengan asam sulfat pada biomassa dari tongkol jagung - bulu ayam efektif untuk menurunkan kadar campuran ion Pb2+ dan Cu2+. Hal ini dikarenakan penambahan PVA dengan asam sulfat dapat memperbesar pori-pori adsorben dari tongkol jagung - bulu ayam serta menambah gugus aktif OH. Hal tersebut ditunjukkan dari hasil analisis BET yang menunjukkan kenaikan luas permukaan sebesar 43,42%, rata-rata pori sebesar 79,55% dan total volume pori 2,5 kali lebih besar dibandingkan adsorben A1.
Editions- und Dokumentwissenschaft an der Bergischen Universität Wuppertal
Authors: Krebs Sophia Victoria , Lukas Wolfgang , Nutt-Kofoth Rüdiger , Platz-Schliebs Anja , Schmidt Karl-Heinrich , Stadler Uwe , Steinhauer Eric W. 
Published: November 2018

Zusammenfassung
Der Masterstudiengang „Editions- und Dokumentwissenschaft“ vermittelt philologische Kompetenzen in Theorie und Praxis der Edition, im Bereich der philologischen Textkritik wie auch in dem der Dokumentverarbeitung. Die wissenschaftlich gesicherte Herstellung, Erschließung und Repräsentation von Texten und ihrer kulturellen Überlieferung steht dabei im Fokus. Im Studiengang werden zudem u. a. modernes informations- und medientechnologisches Wissen, Medienrecht, Typographie und elektronisches Publizieren gelehrt.
Effect of Physical Activity on the Quality of Life in Osteoporotic Females Living in Residential Facilities: A Randomized Controlled Trial
Authors: Nawrat-Szołtysik Agnieszka , Miodońska Zuzanna , Opara Józef , Polak Anna , Matyja Beata , Małecki Andrzej 
Published: November 2018

Background and Purpose:
The study aimed to assess the effect of a program of modified Sinaki exercises and Nordic Walking on the life quality in osteoporotic and osteopenic females living in residential care facilities, taking into account their baseline level of activity and risk of falling. The study was designed as a randomized controlled trial.

Methods:
A sample of 91 females 65 to 98 years of age, the residents of Upper Silesian residential care facilities, was randomized into 4 groups. All groups received the same pharmacological treatment. In group 1 (control group), drugs were the only therapy; in group 2, the therapy was enhanced by program of modified Sinaki exercises; group 3 participated in Nordic Walking workout; and group 4 did both Sinaki exercises and Nordic Walking. Locomotor activity of the participants was estimated from pedometer readings. The risk of falling was assessed with the “Timed Up and Go” Test and the Functional Reach Test. With the QUALEFFO-41 questionnaire, the life quality of the participants was evaluated at baseline and after 12 months of intervention.

Results and Discussion:
The study revealed that the studied women were at high risk of falling and that their physical activity was relatively low, likewise the quality of their lives. Their satisfaction with life was reduced by poor health, limited mobility, and the lack of social activities. Life quality improved in all 3 intervention groups, but in the control group, it decreased. The results of Bonferroni's post hoc test pointed to statistically significantly better quality of life in groups 2 (P = .01) and 4 (P < .01).

Conclusion:
Both modified Sinaki exercises and Nordic Walking significantly improved the participants' quality of life, but the most effective therapeutically was the combination of both these forms of physical activity.
The Long-Term Impact of Renin-Angiotensin System (RAS) Inhibition on Cardiorenal Outcomes (LIRICO): A Randomized, Controlled Trial
Authors: Saglimbene Valeria , Palmer Suetonia C. , Ruospo Marinella , Natale Patrizia , Maione Ausilia , Nicolucci Antonio , Vecchio Mariacristina , Tognoni Gianni , Craig Jonathan C. , Pellegrini Fabio , Lucisano Giuseppe , Hegbrant Jörgen , Ariano Rosario , Lamacchia Olga , Sasso Antonio , Morano Susanna , Filardi Tiziana , De Cosmo Salvatore , Pugliese Giuseppe , Procaccini Deni A. , Gesualdo Loreto , Palasciano Giuseppe , Johnson David W. , Tonelli Marcello , Strippoli Giovanni F.M. ,   on behalf of the Long-Term Impact of RAS Inhibition on Cardiorenal Outcomes (LIRICO) Investigators
Published: November 2018

Background
The comparative effectiveness of treatment with angiotensin-converting enzyme (ACE) inhibitors, angiotensin receptor blockers (ARBs), or their combination in people with albuminuria and cardiovascular risk factors is unclear.

Methods
In a multicenter, randomized, open label, blinded end point trial, we evaluated the effectiveness on cardiovascular events of ACE or ARB monotherapy or combination therapy, targeting BP<130/80 in patients with moderate or severe albuminuria and diabetes or other cardiovascular risk factors. End points included a primary composite of cardiovascular death, nonfatal myocardial infarction, nonfatal stroke, and hospitalization for cardiovascular causes and a revised end point of all-cause mortality. Additional end points included ESRD, doubling of serum creatinine, albuminuria, eGFR, BP, and adverse events.

Results
Because of slow enrollment, the trial was modified and stopped 41% short of targeted enrollment of 2100 participants, corresponding to 35% power to detect a 25% reduced risk in the primary outcome. Our analysis included 1243 adults, with median follow-up of 2.7 years. Efficacy outcomes were similar between groups (ACE inhibitor versus ARB, ACE inhibitor versus combination, ARB versus combination) as were rates of serious adverse events. The rate of permanent discontinuation for ARB monotherapy (6.3%) was significantly lower than for ACE inhibitor monotherapy (15.7%) or combined therapy (18.3%).

Conclusions
Patients may tolerate ARB monotherapy better than ACE inhibitor monotherapy. However, data from this trial and similar trials, although as yet inconclusive, show no trend suggesting differences in mortality and renal outcomes with ACE inhibitors or ARBs as dual or monotherapy in patients with albuminuria and diabetes or other cardiovascular risk factors.
SDÜTF ÖĞRETİM ÜYELERİNİN PROBLEME DAYALI ÖĞRENME KONUSUNDAKİ GÖRÜŞLERİNİN DEĞERLENDİRİLMESİ
Authors: KOLCU Giray , VATANSEVER Kevser , BEYAZIT ÜÇGÜN Ayşenur , TAMAM İbrahim , BAŞER Aysel , KİŞİOĞLU Ahmet Nesimi 
Published: November 2018

Amaç: Çalışmamızda Süleyman Demirel Üniversitesi Tıp
Fakültesi Öğretim Üyelerinin probleme dayalı öğrenme yaklaşımı ile ilgili görüşlerinin değerlendirilmesi
amaçlanmıştır.Yöntem: Araştırmanın Evreni olarak Süleyman Demirel
Üniversitesi Tıp Fakültesi’nde 2017-2018 eğitim-öğretim yılında aktif görevli
olan 93 (%74,4) öğretim üyesine
ulaşılabilmiştir (n:93). Anket dört ana bölümden oluşmaktadır. Bunlar; birinci
bölümde öğretim üyelerinin sosyodemografik özelliklerini sorgulayan 4 soru,
ikinci bölümde öğretim üyelerinin PDÖ konusundaki görüşlerini etkileyebilecek
faktörleri sorgulayan 8 soru, üçüncü bölümde öğretim üyelerinin SDÜTF eğitim
programının mevcut hali ile ilgili görüşlerini sorgulayan 12 soru, dördüncü bölümde öğretim üyelerinin PDÖ ile
ilgili görüşlerini sorgulayan 12 sorudan oluşmaktadır.

Bulgular: Çalışmamızda SDÜTF eğitim programının mevcut hali “orta” PDÖ ile ilgili görüşleri “iyi” olarak
değerlendirilmiştir. Cevaplara beşli ölçekle değerlendirildiğinde katılımcıların
SDÜTF eğitim programı ile ilgili puanların ortalaması 33,34±19,63 (Min: 0,00,
maks: 60,00) , Bununla birlikte PDÖ ile ilgili puanların ortalaması 40,54±11,43(Min:12,00, Max:60,00) olarak bulunmuştur. Çalışmanın
analizlerinde öğretim üyelerinin PDÖ konusundaki görüşleri ile eğitim
programını geliştirme süreci ile ilgili bir komisyonda görev almayı isteme,
eğitim programını değerlendirme süreci ile ilgili bir komisyonda görev almayı
isteme, eğitim yönlendiriciliğinin hizmet ve araştırma etkinliklerini
aksatacağını düşünme, SDÜ mevcut eğitim programının öğrencilerin kazanımlarına
ve ilgi/motivasyon üzerine etkisi arasında anlamlı ilişki bulunmuştur.Tartışma: Fakültemiz öğretim üyeleri için PDÖ yaklaşımını bir gelişim alanı olarak
değerlendirebiliriz. PDÖ
etkinliklerinin öğretim üyelerinin rutin çalışma düzenini etkilemeyecek
düzenlenmelerle planlanması bu yaklaşımın kabullenilmesi ve uygulanmasını
olumlu etkileyebilir. Çalışmamızda öğretim
üyelerinin fakültenin mevcut eğitim programının ilgi ve
motivasyon üzerine olumlu görüşlerinin aynı
şekilde PDÖ ile ilgili görüşlerini de etkileyeceği
bulunmuştur. Bu
bağlamda öğretim üyesi sayısı ve öğrenme ortamlarının planlanması, eğitim
programı geliştirme konusunda eğitici eğitimlerinin tasarlanması ve mevcut
eğitim programının öğrenmeye yönelik ilgi ve motivasyon arttırıcı etkisi ile
öğretim üyelerinin PDÖ konusundaki görüşlerini olumlu etkilediği kanaatindeyiz.
Готовность государственных служащих к управлению проектами
Authors: Федорова Наталья Васильевна , Минченкова Ольга Юрьевна 
Published: November 2018

<p>В статье выделены критерии оценки готовности государственных служащих к управлению в рамках концепции проектного менеджмента, предложена модель формирования профессиональной готовности государственных служащих к управлению проектами, а также этапы, условия, содержание, формы и методы обучения государственных служащих.</p>
Muscle wasting diseases has two distinct trajectories on the 3‐dimensional age‐BMI‐peak VO2 scatterplot
Authors: Sugie Masamitsu , Harada Kazumasa , Takahashi Tetsuya , Nara Marina , Koyama Teruyuki , Fujimoto Hajime , Kyo Shunei , Ito Hideki 
Published: November 2018

AbstractAimsFrailty and sarcopenia are age‐related morbid states, and a low body mass index (BMI) is a characteristic of frailty and cachexia. However, no common index for assessing these three muscle wasting states is available, making it difficult to understand the relationship among them. Peak oxygen uptake (peak VO2), an index of life expectancy, may be a useful common index. Therefore, this study aimed to investigate the relationship among sarcopenia, frailty, and cachexia using age, BMI, and peak VO2.Methods and ResultsParticipants were 175 Japanese community dwelling older adults (58 men, 117 women; 77.6 years). We assessed biochemical, physiological, and physical factors, and symptoms associated with frailty, and cachexia. Peak VO2 was assessed with a cardiopulmonary exercise test. Participants were classified into five groups: robust, pre‐frail, frail, sarcopenia, and cachexia. We compared the groups by age, BMI, and peakVO2 with average values and 95% confidence intervals (CIs). 17% (n=30) of participants were classified as robust, 40% (n=70) as pre‐frail, 12% (n=21) as sarcopenia, 25% (n=44) as frail, and 6% (n=10) as cachexia. Significant differences were found in age (robust vs. frail, pre‐frail vs. frail), BMI (robust vs. cachexia, pre‐frail vs. cachexia, frail vs. cachexia), and peak VO2 (robust vs. frail, robust vs. cachexia, pre‐frail vs. cachexia) with average values and 95% CIs. Three dimensions among age, BMI and peak VO2 revealed two trajectories (from robust to frailty via pre‐frailty, and from robust to cachexia via sarcopenia) among muscle wasting diseases.ConclusionsThis study revealed two trajectories among muscle wasting diseases.
A Discrete Event Simulation Model for the Analysis of Software Quality Attributes
Authors: Bogado Verónica , Gonnet Silvio , Leone Horacio 
Published: November 2018

A discrete event simulation model for evaluating quality attributes, employing the software architecture, is proposed in this work. A metamodel of the software architecture domain that includes the concepts required for measuring quality attributes at runtime is specified. So, a simulation model is built from it, following the principles of hierarchy and modularity, assembling simple blocks to obtain complex blocks. DEVS framework is applied to obtain a decoupled model from the simulator, and the DEVS formalism is used to specify the elements of the simulation model.
The objective of this approach is to provide information about the quality attributes that can be measured at runtime, introducing the discrete event simulation in the context of the software architecture design. This quantitative information will assist the architect to make decisions about the design of the system.
MINING COMPANIES AND LOCAL COMMUNITIES: SOCIAL PARTNERSHIP AS THE BASIS OF CONFLICTFREE DEVELOPMENT (on the example of the province Batu Hijau, Indonesia).Review of: Enacting the Corporation: an American Mining Firm in Post-Authoritarian Indonesia by Marina Welker. Berkeley – Los-Angeles – London: University of California Press, 2014. 289 p.
Authors: Поддубиков В. , Poddubikov V. 
Published: November 2018

<p>The articlerepresents a review of the monograph by American anthropologist Marina Welker (Cornell University,USA), dedicated to the socioanthropological study of the relationship of the American industrial corporation Newmont leading mineral extraction on Sambava island (Indonesia), with the local population communities. Based on results of two-year field work, the author analyzes the most important aspects in terms of social tension in areas of intensive mining, the main components of the conflict discourse around the resource rent extraction and distribution problems, and the experience of the American corporation for the normalization of relations with local communities. The book under review is of considerable interest from the point of view of development in the Russian practice of socio-anthropological research in the problem field extractivism, its social and environmental development impact. This review is available to Russian-speaking reader for the first time. Previously, it has been published twicein foreign scientific journals in English [1] and Estonian [2]. </p>
Water quality assessment and plasmid analysis of multiple antibiotic-resistant Escherichia coli O157:H7 from well-water sources in Ado-Ekiti metropolis, Nigeria
Authors: Oluyege Jacob Olaoluwa , Adeoye Monisade Omolade , Olowe Busayo Mutiat 
Published: November 2018

Abstract
This research aimed to assess the physicochemical and bacteriological quality of underground water, and determine the antibiotic susceptibility and presence of plasmids in multiple antibiotic-resistant (MAR) Escherichia coli O157:H7 in underground water sources in Ado-Ekiti. Physicochemical and bacteriological analysis of water samples were carried out using standard methods, an antibiotic susceptibility test was investigated using the standard disc diffusion method and plasmid analysis of MAR isolates was carried out using the polymerase chain reaction (PCR) technique. The physicochemical parameters analyzed were within WHO recommendations except for pH and potassium while the water samples did not conform to the WHO bacteriological recommendations for drinking water. A total of 272 E. coli were isolated and identified, among which 150 isolates were non-sorbitol fermenters (NSF) and taken as presumptive E. coli O157. MAR to three and more classes of antibiotics used were observed among these NSF with high MAR-Index, &gt;0.2. Plasmid analysis of selected 15 isolates among the MAR NSF showed that their resistance to antibiotics was likely plasmid-mediated as they carry one to two plasmids on them. The study revealed that the water samples from Ado-Ekiti metropolis are unsafe for consumption.
Synthesis and Biological Evaluation of New 1,3,4-Oxadiazoles as Potential Anticancer Agents and Enzyme Inhibitors
Authors: Yurttaş Leyla , Çavuşoğlu Betül K. , Çiftçi Gülşen A. , Temel Halide E. 
Published: November 2018

Background:
1,3,4-Oxadiazoles have been known with a wide variety of pharmacological activities
including anticancer activity.

Objective:
In this study, novel 2,5-disubstituted 1,3,4-oxadiazole derivatives were synthesized and evaluated for
determining their anticancer, anticholinesterase and lipoxygenase (LOX) inhibitory activity.

Methods:
All compounds were tested against C6 rat glioma, A549 human lung carcinoma and NIH/3T3 mouse
embryo fibroblast cell lines to define cytotoxic concentrations and apoptosis induction levels which they cause.

Results:
Many of the compounds exhibited remarkable potency that compounds 2a, 2b, 2e, 2h and 2j against C6
cells and compounds 2a, 2b, 2d, 2g, 2i, 2j against A549 cells were found more active than cisplatin. Compound
2d namely, 2-[(5-(4-aminophenyl)-1,3,4-oxadiazol-2-yl)thio]-1-(4-chlorophenyl)ethan-1-one induced apoptosis
of A549 cells with 74.9% whereas cisplatin caused 70.9% percentage.

Conclusion:
Among them, compounds 2d and 2j against A549 cell line, compounds 2b and 2e against both
tumor cell lines showed selective cytotoxicity evaluating the inhibition concentration against NIH/3T3 cell line.
None of the compounds showed significant acetylcholinesterase (AChE) and lipoxygenase inhibitory activities.
Determination of Usnic Acid Responsive miRNAs in Breast Cancer Cell Lines
Authors: Kiliç Nil , Islakoğlu Yasemin Ö. , Büyük İlker , Gür-Dedeoğlu Bala , Cansaran-Duman Demet 
Published: November 2018

Objective:Breast Cancer (BC) is the most common type of cancer diagnosed in women. A common treatment strategy for BC is still not available because of its molecular heterogeneity and resistance is developed in most of the patients through the course of treatment. Therefore, alternative medicine resources as being novel treatment options are needed to be used for the treatment of BC. Usnic Acid (UA) that is one of the secondary metabolites of lichens used for different purposes in the field of medicine and its anti-proliferative effect has been shown in certain cancer types, suggesting its potential use for the treatment.Methods:Anti-proliferative effect of UA in BC cells (MDA-MB-231, MCF-7, BT-474) was identified through MTT analysis. Microarray analysis was performed in cells treated with the effective concentration of UA and UA-responsive miRNAs were detected. Their targets and the pathways that they involve were determined using a miRNA target prediction tool.Results:Microarray experiments showed that 67 miRNAs were specifically responsive to UA in MDA-MB-231 cells while 15 and 8 were specific to BT-474 and MCF-7 cells, respectively. The miRNA targets were mostly found to play role in Hedgehog signaling pathway. TGF-Beta, MAPK and apoptosis pathways were also the prominent ones according to the miRNA enrichment analysis.Conclusion:The current study is important as being the first study in the literature which aimed to explore the UA related miRNAs, their targets and molecular pathways that may have roles in the BC. The results of pathway enrichment analysis and anti-proliferative effects of UA support the idea that UA might be used as a potential alternative therapeutic agent for BC treatment.
KUALITAS AIR SUNGAI GAJAH WONG DITINJAU DARI PENGHAMBATAN ENZIM ASETILKOLINESTERASE (Water Quality Assessment of Gajah Wong River Based on Inhibition of Acetylcholinesterase Activity)
Authors: Riswanto Florentinus Dika Octa , Hariono Maywan , Susanto Gatot Nugroho , Budiasmoro Ignatius Yulius Kristio , Istyastono Enade Perdana 
Published: November 2018

ASBTRAKSungai Gajah Wong, salah satu sungai di kota Yogyakarta, dikhawatirkan terpapar pencemaran air akibat pembuangan limbah rumah tangga, industri, rumah sakit maupun hotel yang masuk ke dalam alirannya. Hal ini menyebabkan penurunan kualitas air sungai dan menimbulkan dampak negatif bagi makhluk hidup yang memanfaatkannya. Pencemaran air sungai tersebut dapat diamati secara biokimiawi berdasarkan uji aktivitas penghambatan enzim asetilkolinesterase (AChE) oleh cemaran pestisida organofosfat dan karbamat. Uji biokimiawi dalam analisis kualitas air terhadap penghambatan AChE dapat dilakukan secara kolorimetrik menurut metode Ellman. Hasil reaksi ini dapat diamati secara melalui pembentukan senyawa berwarna dan serapannya dapat diukur pada panjang gelombang visibel. Penentuan lokasi sampling pada penelitian didasarkan pada pertimbangan sebaran muatan polusi/diffuse pollution loads consideration. Ditetapkan enam lokasi pengambilan sampel air sungai yaitu GW-1, GW-2, GW-3, GW-4, GW-5, dan GW-6 berturut-turut dari utara ke selatan. Dari keenam lokasi, GW-6 sebagai titik paling selatan dalam jalur pengambilan sampel menunjukkan penghambatan aktivitas AChE yang paling tinggi ditunjukkan dengan aktivitas AChE yang rendah. ASBTRACTGajah Wong River, one of the rivers in Yogyakarta city, was threatened by contamination of water pollutant due to the disposal waste of households, industrials, hospitals and hotels into its stream. The pollutions might cause the decreasing of water quality and raised the negative impact to living creatures that exploit it. River pollutions can be observed biochemically based on inhibition of acetylcholinesterase (AChE) enzyme activity by organophosphate and carbamate pesticide contamination. Biochemical assay in the analysis of water quality could be done according to the colorimetric of Ellman’s method. The results of this reaction can be observed by measuring the formation of colored compounds at visible wavelengths. Determination of the sampling location in this research was performed based on diffuse pollution loads consideration. Six sampling sites was defined and named as GW-1, GW 2, GW 3, GW 4, GW-5, and GW-6, respectively in a row from north to south. As the results, water from GW-6 as the southernmost site in the sampling sites showed the highest inhibition of AChE activity.
Bibliografía de filología hispánica
Authors: De Filología Hispánica Nueva Revista 
Published: November 2018

Las reseñas se consignan a continuación del libro (o artículo reseñado). Cuando éste se ha descrito en una entrega anterior de la Bibliografía, se pone entre paréntesis el número de ficha correspondiente. También se hacen referencias a ediciones anteriores de una obra, a tomos anteriores de una obra en curso de publicación, etc. En estos casos, la cifra que precede al número de referencia indica el volumen de la NRFH en que figura la ficha en cuestión. Así, el "núm. 39-39695" corresponde a la ficha 39695, la cual está en el volumen 39 de la NRFH. Cuando no hay cifra inicial, ha de entenderse que el número remite a una ficha incluida en el presente fascículo.