bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identification of risk variants and characterization of the polygenic architecture of disruptive behavior disorders in the context of ADHD
Authors: Demontis Ditte , Walters Raymond , Rajagopal Veera M. , Waldman Irwin D. , Grove Jakob , Als Thomas D. , Dalsgaard Søren , Ribases Marta , Grauholm Jonas , Bækvad-Hansen Marie , Werge Thomas , Nordentoft Merete , Mors Ole , Mortensen Preben Bo ,   ADHD Working Group of the Psychiatric Genomics Consortium (PGC), Cormand Bru , Hougaard David M. , Neale Benjamin M. , Franke Barbara , Faraone Stephen V. , Børglum Anders D. 
Published: October 2019

AbstractAttention-Deficit/Hyperactivity Disorder (ADHD) is a childhood psychiatric disorder often comorbid with disruptive behavior disorders (DBDs). ADHD comorbid with DBDs (ADHD+DBDs) is a complex phenotype with a risk component that can be attributed to common genetic variants. Here we report a large GWAS meta-analysis of ADHD+DBDs based on seven cohorts in total including 3,802 cases and 31,305 controls. Three genome-wide significant loci were identified on chromosomes 1, 7, and 11. A GWAS meta-analysis including a Chinese cohort supported the locus on chromosome 11 to be a strong risk locus for ADHD+DBDs across European and Chinese ancestries (rs7118422, P=3.15×10-10, OR=1.17). This locus was not associated with ADHD without DBDs in a secondary GWAS of 13,583 ADHD cases and 22,314 controls, suggesting that the locus is a specific risk locus for the comorbid phenotype.We found a higher SNP heritability for ADHD+DBDs (h2SNP =0.34) when compared to ADHD without DBDs (h2SNP =0.20). Genetic correlations of ADHD+DBDs with aggressive (rg =0.81) and anti-social behaviors (rg=0.82) were high, and polygenic risk score analyses revealed a significant increased burden of variants associated with ADHD and aggression in individuals with ADHD+DBDs compared to ADHD without DBDs. Our results suggests that ADHD+DBDs represent a more severe phenotype with respect to the genetic risk load than ADHD without DBDs, in line with previous studies, and that the risk load to some extent can be explained by variants associated with aggressive behavior.
Effects of Aging on the Encoding of Spatial Direction in the Human Brain
Authors: Koch Christoph , Li Shu-Chen , Polk Thad A. , Schuck Nicolas W. 
Published: October 2019

AbstractHuman aging is characterized by impaired spatial cognition and reductions in the distinctiveness of category-specific fMRI activation patterns. Yet, little is know about age-related decline in neural distinctiveness of spatial information. Here, we asked whether neural tuning functions of walking direction are broadened in older versus younger adults. To test this idea, we developed a novel method that allowed us to investigate changes in fMRI-measured pattern similarity while participants navigated in different directions in a virtual spatial navigation task. We expected that directional tuning functions would be broader in older adults, and thus activation patterns that reflect neighboring directions would be less distinct as compared to non-adjacent directions. Because loss of distinctiveness leads to more confusions when information is read out by downstream areas, we analyzed predictions of a decoder trained on these representations and asked (1) whether decoder confusions between two directions increase proportionally to their angular similarity, (2) and how this effect may differ between age groups. Evidence for tuning-function-like signals was found in the retrosplenial complex and primary visual cortex. Significant age differences in tuning width, however, were only found in the primary visual cortex, suggesting that less precise visual information could lead to worse directional signals in older adults. Yet, age differences in visual tuning were not related to behavior. Instead, directional information encoded in RSC correlated with memory on task. These results shed new light on neural mechanisms underling age-related spatial navigation impairments and introduce a novel approach to measure tuning specificity using fMRI.
Micro-scale fluid behavior during cryo-EM sample blotting
Authors: Armstrong M. , Han B-G. , Gomez S. , Turner J. , Fletcher D. A. , Glaeser R. M. 
Published: October 2019

ABSTRACTBlotting has been the standard technique for preparing aqueous samples for single-particle electron cryo-microscopy (cryo-EM) for over three decades. This technique removes excess solution from a TEM grid by pressing absorbent filter paper against the specimen prior to vitrification. However, this standard technique produces vitreous ice with inconsistent thickness from specimen to specimen and from region to region within the same specimen, the reasons for which are not understood. Here, high-speed interference-contrast microscopy is used to demonstrate that the irregular pattern of fibers in the filter paper imposes tortuous, highly variable boundaries during removal of excess liquid from a flat, hydrophilic surface. As a result, aqueous films of nonuniform thickness are formed while the filter paper is pressed against the substrate. This pattern of nonuniform liquid thickness changes again after the filter paper is pulled away, but the thickness still does not become completely uniform. We suggest that similar topological features of the liquid film are produced during the standard technique used to blot EM grids and that these manifest in nonuniform ice after vitrification. These observations suggest that alternative thinning techniques, which do not rely on direct contact between the filter paper and the grid, may result in more repeatable and uniform sample thicknesses.STATEMENT OF SIGNIFICANCEMultiple imaging techniques are used to observe dynamic, micro-scale events as excess water is removed from a substrate by blotting with filter paper. As a result, new insight is gained about why the thickness values of remaining sample material are so variable across a single EM grid, as well as from one grid to the next. In addition, quantitative estimates are made of the shear forces to which macromolecular complexes can be exposed during blotting. The fact that sample thicknesses and flow rates are seen to be inherently under poor control during blotting suggests that other methods of removing excess water may be better suited for consistently achieving large sample areas that are suitable for use in electron cryo-microscopy.
Social inequity, taxes and welfare in Australasia
Authors: Marriott Lisa , Sim Dalice 
Published: October 2019

Purpose
The purpose of this paper is to highlight, challenge and explain the inequitable treatment of tax and welfare fraudsters in the criminal justice systems of Australia and New Zealand. The authors offer prejudice by way of explanation and suggest that it is also prejudice that restricts the implementation of more equitable processes. A second objective of the study is to highlight the importance of critical tax research as an instrument to agitate for social change.

Design/methodology/approach
A survey captures 3,000 respondents’ perceptions of the likelihood that different “types” of people will commit welfare or tax fraud. Using social dominance theory, the authors investigate the extent to which prejudice impacts on attitudes towards those engaged in these fraudulent activities.

Findings
The authors find the presence of traditional stereotypes, such as the perception that businessmen are more likely to commit tax fraud and people receiving welfare assistance are more likely to commit fraud. The authors also find strong preferences towards respondents’ own in-group, whereby businessmen, Maori and people receiving welfare assistance believed that their own group was less likely to commit either crime.

Social implications
Where in-group preference exists among those who construct and enforce the rules relating to investigations, prosecutions and sentencing of tax and welfare fraud, it is perhaps unsurprising that welfare recipients attract less societal support than other groups who have support from their own in-groups that have greater power, resources and influence.

Originality/value
The study highlights the difficulty of social change in the presence of strong in-group preference and prejudice. Cognisance of in-group preference is relevant to the accounting profession where elements of self-regulation remain. In-group preferences may impact on services provided, as well as professional development and education.
The civic mission of schools and students’ participation in school governance
Authors: Yuen Timothy Wai Wa , Cheng Chi Keung Eric , Guo Chunlan , Leung Yan Wing 
Published: October 2019

Purpose
The purpose of this paper is to examine the relationships between the civic mission of schools and students on participation in school governance through an empirical study. It articulates the importance of school mission on nurturing citizenship of high school students.

Design/methodology/approach
The research used a mixed method with questionnaire survey in the first phase and qualitative interviews in the second phase. Quantitative data were obtained from a survey completed by 3,209 students and 495 teachers (including principals) from 51 secondary schools in Hong Kong. Qualitative data were collected from 41 individual interviews with principals and teachers and 17 focus group interviews with 56 students in five case study schools.

Findings
Both students and teachers believed that good citizenship qualities should include students’ participation in school governance. Schools in general took up the civic mission to nurture good and participatory citizens. A mission of nurturing students to become good and participatory citizens made a significant and positive contribution toward achieving students’ actual participation in school governance. However, students’ actual impact on major school policies was minimal. A paradox existed whereby students, knowing their influence over managerial issues was much circumscribed, still gave it a higher rating than their teachers.

Originality/value
The paper contributes an empirical model for school leaders to develop school vision for promoting student participation in school governance. Based on a large-scale research supported by public funding, the paper contributes an empirical model for school leaders to develop school vision for promoting student participation in school governance. It further adds to the literature on relationship between citizenship education, civic mission of school and student participation in governance.
Combating police corruption in five Asian countries: a comparative analysis
Authors: Quah Jon S.T. 
Published: October 2019

PurposeThe purpose of this paper is to analyse the contextual differences and causes of police corruption in Indonesia, Japan, the Philippines, South Korea and Taiwan and to assess their governments’ effectiveness in minimising this problem.Design/methodology/approachThe paper begins by identifying the contextual differences in the five countries before analysing their major causes of police corruption and their governments’ effectiveness in minimising it.FindingsPolice corruption is a more serious problem in Indonesia and the Philippines because of their more difficult governance environments, low salaries of police officers, red tape, lack of meritocracy in recruitment and promotion, and lack of accountability of police officers. By contrast, the perceived extent of police corruption has declined in Japan, South Korea and Taiwan in recent years because of the improvement in the salaries of their police officers and the implementation of various police reforms.Originality/valueThis comparative analysis of combating police corruption in five Asian countries will be of interest to policy makers and scholars concerned with minimising this problem.
Stock pledging and earnings management: an empirical analysis
Authors: Bhatia Sandhya , Choudhary Sangita , Dugar Amish , Mazumdar Smita 
Published: October 2019

Purpose
The purpose of this paper is to investigate the impact of agency risk implied in case of personal debt obtained by promoters through pledging of their stock on accrual and real earnings management practices.

Design/methodology/approach
In this paper abnormal accruals, as suggested in Dechow et al. (1995), and the real earnings management proxies as indicated in Dechow et al. (1998) and Roychowdhury (2006) are used. OLS regression is run over 29,054 firm-years of Indian companies starting from the year 2008 to 2016. Then the occurrence of earnings management is tested in firms in year t where promoters pledge/release their holdings from the pledge in year t+1.

Findings
The findings suggest that earnings management increases in the prior year with an increase in the proportion of promoters’ stock pledge in the subsequent year. The authors find evidence for increased earnings management through accruals and also for real earnings management using abnormal cash flows and abnormal discretionary expenses. However, the authors do not find real earnings management using abnormal production cost as a measure.

Practical implications
The paper has considerable implications on managerial behavior toward earnings management because of the flexibility managers have in applying accounting policies and authority in operating decisions under domestic GAAP, and IFRS and earnings are prone to management tactics, fostering agency risk when they relate to the welfare of decision makers.

Originality/value
This paper addresses the consequences of individual borrowing of promoters collateralized by their stake in the firm, which is a global phenomenon, on reporting quality.
Compliance costs and comparability benefits of cross-listing
Authors: Wang Shiheng , Wu Serena 
Published: October 2019

Purpose
The purpose of this paper is to examine two channels through which accounting standard differences could affect cross-listing: compliance costs and/or comparability benefits.

Design/methodology/approach
The authors use two settings to disentangle the two channels. First, financial reporting requirements are more stringent for cross-listings via direct listings than cross-listings via depositary receipts; as a result, the effect of compliance costs (if any) would be manifested differently in the two venues of cross-listings. Second, some host countries allow foreign firms to report under International Financial Reporting Standards (IFRS) without mandating IFRS for domestic firms; compared to host countries that mandate IFRS for both domestic and foreign firms, these IFRS-permitting countries provide a setting to test the importance of comparability benefits while holding constant compliance costs.

Findings
The authors find that prior to IFRS adoption, direct listings decrease with accounting standards differences between two countries while depositary receipts increase with such differences, consistent with the costs of complying with host country’s accounting standards affecting firms’ cross-listing decisions. After the harmonization of accounting standards, the authors find that IFRS-mandating host countries gain cross-listings from other IFRS-mandating jurisdictions, while IFRS-permitting countries do not experience such gains. These combined results suggest that accounting related compliance costs and comparability benefits both influence cross-listing decisions.

Originality/value
The paper employs unique settings that enable an in-depth examination of the role of compliance costs vs that of comparability benefits on cross-listing decisions. The settings employed by the authors allow them to disentangle the two channels and provide an important insight that accounting standard-related compliance costs and comparability benefits both affect cross-listing decisions.
Shelf life prediction model of postharvest table grape using optimized radial basis function (RBF) neural network
Authors: Li Yue , Chu Xiaoquan , Fu Zetian , Feng Jianying , Mu Weisong 
Published: October 2019

Purpose
The purpose of this paper is to develop a common remaining shelf life prediction model that is generally applicable for postharvest table grape using an optimized radial basis function (RBF) neural network to achieve more accurate prediction than the current shelf life (SL) prediction methods.

Design/methodology/approach
First, the final indicators (storage temperature, relative humidity, sensory average score, peel hardness, soluble solids content, weight loss rate, rotting rate, fragmentation rate and color difference) affecting SL were determined by the correlation and significance analysis. Then using the analytic hierarchy process (AHP) to calculate the weight of each indicator and determine the end of SL under different storage conditions. Subsequently, the structure of the RBF network redesigned was 9-11-1. Ultimately, the membership degree of Fuzzy clustering (fuzzy c-means) was adopted to optimize the center and width of the RBF network by using the training data.

Findings
The results show that this method has the highest prediction accuracy compared to the current the kinetic–Arrhenius model, back propagation (BP) network and RBF network. The maximum absolute error is 1.877, the maximum relative error (RE) is 0.184, and the adjusted R2 is 0.911. The prediction accuracy of the kinetic–Arrhenius model is the worst. The RBF network has a better prediction accuracy than the BP network. For robustness, the adjusted R2 are 0.853 and 0.886 of Italian grape and Red Globe grape, respectively, and the fitting degree are the highest among all methods, which proves that the optimized method is applicable for accurate SL prediction of different table grape varieties.

Originality/value
This study not only provides a new way for the prediction of SL of different grape varieties, but also provides a reference for the quality and safety management of table grape during storage. Maybe it has a further research significance for the application of RBF neural network in the SL prediction of other fresh foods.
Street food traders, farmers and sustainable practice to reduce food waste in the Italian context
Authors: Alfiero Simona , Christofi Michael , Bonadonna Alessandro 
Published: October 2019

PurposeThe purpose of this paper is to demonstrate how food waste management can affect both retail and distribution operators’ efficiency performance and their ability to create value. In particular, the paper shows how optimizing food waste management characterizes best practices and favors the development of sustainability.Design/methodology/approachBased on a survey of 196 outdoor market operators (including farmers and street food traders) from 27 outdoor markets, the authors analyzed unsold food/food wastage processesvis-à-visthe operators’ behavior and attitude. To provide accurate definitions of the satisfaction levels, a consumer perception survey was carried out, with a usable sample of 2,107 questionnaires. The efficiency performance was evaluated according to data envelopment analysis.FindingsThe results showed that farmers operate more efficiently than street food traders and that the traditional management of unsold food/food waste is an important competitive element in this sector.Research limitations/implicationsThe sample represents the Greater Turin Area in Italy, i.e., thus, limiting generalizability of the results. In addition, the variables analyzed were limited to certain aspects of selling processes and food waste management.Practical implicationsThe results provide some indicators on how a more rational style of unsold food management can improve an operators’ performance and help make a social impact.Originality/valueTo the best of the authors’ knowledge, this is the first study that analyses outdoor market operators’ efficiency, based on the use of food waste as a variable affecting their performance.
Consumers impact on food quality under frozen conditions in Germany
Authors: Kölzer Beate Silvia , Geppert Jasmin , Klingshirn Astrid , Weber Harald , Brugger Lilla , Engstler Antje , Härlen Jochen , Ertel Thomas , Gindele Thomas , Stamminger Rainer 
Published: October 2019

Purpose
More than 50 per cent of all German households own a freezing appliance and so far the market of frozen foods is constantly increasing (1 per cent from 2017 to 2018). Despite frozen foods playing an important role in our everyday life, little is known about the consumer’s habits at home. The purpose of this paper is to uncover gaps in the knowledge about consumer behaviour when handling frozen food. Moreover, the impact of consumers on the quality of frozen products should be assessed.

Design/methodology/approach
A representative online survey was carried out to investigate different aspects of consumer behaviour concerning frozen foods. Respondents (n=2,053) were questioned about their general handling habits regarding eight different food groups: fruit, vegetables, meat, fish, bread, pastries, ready-to-eat meals and leftovers. The focus was on freezing, pre-handling, packaging and thawing – depending on the age of those questioned and combined with best practice advice regarding quality storage of frozen products.

Findings
Most Germans have the opportunity to freeze food and keep their freezers full or medium loaded. Older participants act more efficiently towards quality storage, but more education about freezing and frozen storage would be generally helpful to maintain quality of frozen foods and increase utilisation of freezers, using their full preservation potential.

Research limitations/implications
No open questions were asked due to the scope of more than 2,000 participants, which, in retrospect, would have been instructive.

Originality/value
Consumer handling of frozen food in Germany was investigated in a representative way for the first time, covering age groups from 18 to 69 and household sizes from 1 to >4 people, focussing on eight major food groups.
Tomato attributes and consumer preferences – a consumer segmentation approach
Authors: Jürkenbeck Kristin , Spiller Achim , Meyerding Stephan G.H. 
Published: October 2019

Purpose
Vegetables are an important component of a healthy diet. Given that tomatoes are the most purchased vegetable in Germany, the purpose of this paper is to focus on how consumers evaluate tomatoes during their food choice. Each consumer has different preferences and, in order to target them, it is necessary to identify consumer groups. The study segments tomato consumers into homogenous target groups.

Design/methodology/approach
A choice experiment was used to simulate the buying situation in a supermarket. The data were analysed using latent class analysis, as well as principal component factor analysis to measure food-related lifestyles. The sample consisted of 1,027 consumers and was representative of the characteristics of gender, age, educational level and income for the German population.

Findings
Consumers perceive air transportation and plastic wrapping as most climate damaging in tomato production. Six different tomato consumer groups were identified and named according to the attribute they found most important, i.e. “Balanced consumers”, “Price-conscious consumers”, “Taste enthusiasts”, “Colour-sensitive consumers”, “Price-conscious consumers with a taste preference” and “Colour- and price-sensitive consumers”. In three clusters, colour was the most important attribute. However, green and yellow tomatoes were rejected by all segments, indicating communication problems.

Originality/value
The results of this study provide breeders and marketers with valuable insights into the factors driving tomato choice. The information was based on a large sample and will help breeders to select the types of tomatoes that are in demand by consumers.