bluuebunny/crossref_metadata_2025_split huggingface dataset:
Anticancer Activity and Topoisomerase II Inhibition of Naphthalimides with ω-Hydroxylalkylamine Side-Chains of Different Lengths
Authors: Tomczyk Mateusz D. , Byczek-Wyrostek Anna , Strama Klaudia , Wawszków Martyna , Kasprzycki Przemysław , Walczak Krzysztof Z. 
Published: September 2018

Background:
The substituted 1,8-Naphthalimides (1H-benzo[de]isoquinoline-1,3(2H)-
diones) are known as DNA intercalators stabilizing DNA-Topoisomerase II complexes. This interaction
disrupts the cleavage-relegation equilibrium of Topo II, resulting in formation of broken
strands of DNA.

Objective:
To investigate the influence of type of substituents and substitution positions in 1,8-
naphthalimde skeleton on the inhibition of Topoisomerase II activity.

Methods:
The starting 1,8-naphthalimide were prepared from acenaphthene by introduction of
appropriate substituents followed by condensation with ω-hydroxylakylamines of different chain
length. The substituents were introduced to 1,8-naphthalimide molecule by nucleophilic substitution
of leaving groups like nitro or bromo present in 4 or 4,5- positions using the ω-
hydroxylalkylamines. The bioactivity of obtained compounds was examined in model cell lines.

Results:
Antiproliferative activity of selected compounds against HCT 116 human colon cancer
cells, human non-small cell lung cells A549 and non-tumorigenic BEAS-2B human bronchial
epithelium cells was examined. Several of investigated compounds exhibit a significant activity
(IC50 µM to 7 µM) against model cancer cell lines. It was demonstrated that upon treatment with
concentration of 200 µM, all derivatives display Topo II inhibitory activity, which may be compared
with activity of Amonafide.

Conclusion:
The replacement of the nitro groups in the chromophore slightly reduces its anticancer
activities, whereas the presence of both nitro group and ω-hydroxylalkylamine chain resulted
in seriously increased anticancer activity. Obtained compounds showed Topo II inhibitory activity,
moreover, influence of the substitution pattern on the ability to inhibit Topo II activity and
cancer cells proliferation was observed.
Celastrus Orbiculatus Extract Potentiates the Sensitivity of Cisplatin Via Caspase-Depenent Apoptosis in Gastric Cancer
Authors: Wang Weimin , Zhou Yan , Yao Qiang , Liu Weihua , Xiang Liangliang , Ni Tengyang , Dai Xiaojun , Liu Yanqing 
Published: September 2018

Background:
Cisplatin-based treatment often leads to therapeutic failure because the acquisition of
cisplatin resistance. The combination of cisplatin with other agents has been recognized as a promising strategy to
overcome cisplatin resistance.

Objective:
Celastrus orbiculatus is a traditional Chinese medicine from Celastraceae family with multiple
pharmacological activities. We previously found that the ethyl acetate extract of Celastrus orbiculatus (COE)
exhibited significant antitumor activity in gastric cancer. Here, we asked whether COE could increase the sensitivity
of cisplatin.

Methods:
We use CCK8 assay to show synergistic cytotoxicity of COE and cisplatin. Then, PI single staining and
FITC-Annexin V/PI double staining were used to observe apoptotic cells through flow cytometry. The proteins of
caspase signaling pathway were examined by Western blotting.

Results:
COE and cisplatin showed synergistic cytotoxicity in a dose-dependent manner in BGC 823 and SGC 7901
gastric cancer cells, and COE could increase the number of apoptotic cells upon cisplatin treatment in vitro.
Moreover, our results indicated that COE could enhance cisplatin–induced activation of caspase-8 or caspase-
9/caspase-3/PARP1 signaling pathways. The xenograft study further confirmed that COE increased the sensitivity of
cisplatin in vivo.

Conclusion:
Our findings provided new evidence that COE could increase the sensitivity of cisplatin on the
antitumor effect.
Protective Effects of Curcumin Against Nephrotoxic Agents
Authors: Farkhondeh Tahereh , Samarghandian Saeed , Azimi-Nezhad Mohsen , Shahri Ali M.P. 
Published: September 2018

Background:Curcumin is the one of the main phenolic ingredients in curcuma species rhizome. Curcuma species have traditionally been used for the treatment of diabetes, cardiovascular, and renal diseases.Methods:The present study was designed to review the scientific literature on the protective effects of curcumin against nephrotoxic agents.Results:Studies have shown the protective effects of curcumin against nephrotoxic agents such as gallic acid, glucose, tartrazine, streptozotocin, lead, cadmium, fluoride, maleate, malathion, nicotine, cisplatin, gentamicin, and methotrexate. However, further investigations are needed to determine the efficacy of curcumin as an antidote agent due to the lack of clinical trial studies. Therefore, it is recommended to conduct clinical trials in humans to confirm these effects.Conclusion:The current review indicated that curcumin may be effective against nephrotoxicity by modulating oxidative stress and inflammatory responses.
Çocuklarda Ameliyathane Dışı Anestezi Uygulamaları
Authors: Keskin Gülsen 
Published: September 2018

Son yıllarda sağlık alanındaki teknolojik gelişmeler, ameliyathane dışı ortamlarda çocuklara yönelik tanısal ve girişimsel işlemler için sedasyon ve analjezi ihtiyacını arttırmıştır. Çocuğun yaşına, psikolojik durumuna, mevcut hastalığına ve yapılacak işleme uygun sedasyon yöntemi seçilmelidir. Ameliyathane dışı anestezi ekibinin varlığı sedasyon başarısını arttırırken, ortaya çıkabilecek olumsuzluklara engel olur.Sağlık alanındaki gelişmelerle ameliyathane dışı tanı ve tedavi uygulamaları giderek artmakta ve anesteziyologlar için yeni zorluklar oluşturmaktadır. Radyoloji, Gastroenteroloji, Üroloji, Kadın Hastalıkları ve Doğum, Kardiyoloji, Nöroloji, Çocuk Hematoloji ve Onkoloji, Psikiyatri, Göğüs Hastalıkları, Kulak Burun Boğaz Bölümü ve Diş Hekimliği gibi birçok alanda ameliyathane dışı anestezi (ADA) uygulamaları yapılmaktadır.
Gambaran Angka Prevalensi Mikrofilaria di Kabupaten Banyuasin Pasca Pengobatan Massal Tahap III
Authors: Oktarina Reni , Santoso Santoso , Taviv Yulian 
Published: September 2018

Filariasis is a chronic infectious disease that can cause permanent disability. One effort to interrupt transmission of filariasis is the Mass Drug Administration filariasis (MDA filariasis) in endemic areas of filariasis for 5 years. In 2012, MDA filariasis was carried out in all regions of Banyuasin. After treatment the 3rd year, it is necessary to evaluate the prevalence of microfilaria and microfilaria density. This activity was conducted by finger blood survey to people who’s living in sentinel and spot villages. This study selected 930 people for SDJ activities The test results obtained 4 positive of microfilaria Brugia malayi. The prevalence or microfilaria rate (Mf rate) in the village of sentinel was 0,96 with microfilaria density were 938/mL of blood, Mf rate in spot village was 0.31 with a microfilaria density were 217.75/mL of blood, while the Mf rate district was 0.43 with a microfilaria density were 716.06/mL of blood. People who suffer filiariasis mostly are farmers/fishermen. The prevalence of microfilariae in Banyuasin decreased, but the risk of transmission can still occur because of the density of microfilariae found> 50/mL of blood.
Relationship of Cash Conversion Cycle with Firm Size, Working Capital Approaches and Firm’s Profitability: A Case of Pakistani Industries
Authors: Bhutto Niaz Ahmed , Abbas Ghulam , Rehman Mujeeb ur , Shah Syed Mir M 
Published: September 2018

<span>This study is aimed to analyze the comparative performance management of different industrial<span> groups at single time scale from multiple perspectives. The study investigates the relationship<span> between the length of CCC, firm size, firm profitability and aggressive/conservative Working<span> Capital policies of 12 industrial groups. Descriptive analysis, Pearson correlation and Analysis of<span> Variance (ANOVA) with post-hoc test (Least Significant Differences) have been used for<span> empirical investigation. The data is collected from the financial statements of the 157 public<span> limited companies listed in the Karachi Stock Exchange (KSE) for the year 2009. It is found that<span> significant differences lie among the mean values of CCC across the Industries and more<span> specifically, Oil and Gas industry is significantly different from all the other industries in term of<span> its length of CCC. Findings of the study show that there is a significant and positive relationship<span> between firms’ aggressive investing policies and conservative financing policies. It is concluded<span> that length of CCC has negative relationship with sales revenue, return on equity (ROE) and<span> financing policies of the firms and has positive relationship with total assets, return on assets <span>(ROA) and investing policies of firms. The practical implications of this study are for the<span> management of the firms to consider the importance of the length of CCC in formulating their<span> policies because the length of CCC is closely related to aggressive/conservative Working Capital<span> approaches of firms. This is the first study of its nature conducted in Pakistan so far which has<span> taken into account all these variables simultaneously and tried to investigate their relationship<span> with each other.<br /><br class="Apple-interchange-newline" /></span></span></span></span></span></span><br /><br class="Apple-interchange-newline" /></span></span></span></span></span></span></span></span></span></span></span></span></span>
The Effects of Contract Framing on Misconduct and Entitlement
Authors: Nichol Jennifer E. 
Published: September 2018

ABSTRACT
This study examines the effects of incentive contract framing on misreporting and entitlement. I conduct a 2 × 2 between-subjects experiment, manipulating incentive contract framing (Bonus/Penalty) and the awareness of the opportunity to misreport (Before Effort/After Effort). I predict and find that (1) penalty contracts cause a higher rate and degree of misreporting, and (2) this greater misreporting occurs due to a greater sense of entitlement to the incentive funds. Collectively, this study's theory and results indicate that while penalty contracts can sometimes increase effort relative to bonus contracts, they also encourage greater dishonesty in reporting when that effort is not successful.
Data Availability: Contact the author.
Effect of Sweet Marjoram (Origanum majorana L.) Cogermination and Aqueous Extracts on Maize (Zea mays L.)
Authors: Bonea Dorina , Urechean Viorica 
Published: September 2018

Abstract
The purpose of this study was to examine the allelopathic effect of sweet marjoram (O. majorana) on the germination and early stages of maize seedlings. Two experiments were performed under laboratory conditions (in Petri dishes). In the first experience, Origanum majorana seeds were cogerminated with maize (Zea mays) seeds in the same Petri dish. For the second experience were used aqueous extracts from fresh and dry aboveground biomass of the sweet marjoram (stem, leaves) in concentrations of 1%, 2% and 3%. Cogermination of O. majorana with maize seeds has significantly stimulated the germination index (Gi) and growth of maize seedlings. Aqueous extracts of sweet marjoram in a concentration of 1% and 2% have significantly stimulated shoot length of maize. On the other hand, aqueous extracts at a concentration of 3% significantly inhibited root length of maize. These results suggest that the cogermination with sweet marjoram seeds may be an alternative to biostimulation of maize initial growth, and aqueous extracts in low concentrations could be used as growth bioregulators.
Researches Regarding New and Improved Technologies for Sunflower and Sorghum Crops in the Context of Climate Changes in Dobrogea Region
Authors: Manole Dumitru , Jinga Vasile , Giumba Ana Maria , Dudoiu Roxana , Cristea Stelica 
Published: September 2018

Abstract
At Sport Agra in Amzacea, in the last few years there have been experimented new sunflower and sorghum crop technologies designed to face the current climate changes. These technologies for the intended crops include the following elements: changing the sowing epoch with one month before the usual period recommended by classical technologies; application of herbicides in order to control both weeds and Orobanche cumana Wallr. parasite in plots cultivated with various hybrids from Syngenta and Limagrain companies; application of last generation fungicides during the vegetation period, which will reduce the attack of the main crop pathogens; screening of hybrids with good behavior towards the main pest agent of area - Orobanche cumana parasite, which cause important yield losses in the south east past of Romania. There were tested 8 hybrids from Syngenta Company, 6 hybrids from Limagrain and 4 hybrids from NARDI Fundulea. The yields obtained for most of the hybrids were over 4 t/ha. For sorghum crop, there were performed various experiments such as: changing the sowing period - beginning of April in order to benefit from the soil’s humidity at 4-5 cm depth boosting the germination process; choosing early hybrids in order to avoid the drought season which starts in June; applying adequate crop protection treatments, with pre-emergent and postemergent herbicides and last generation insecticides. The obtained production from sorghum crop were over 10 t/ha for most of the varieties tested.
Extreme Dry Years in the 21st Century at the Level of the Agricultural Areas of Muntenia, Romania
Authors: Oprea Oana-Alexandra , Mateescu Elena , Barbu Anda , Tudor Rodica 
Published: September 2018

Abstract
The global climatic changes consisting of the increased in the average air temperature and changes in the rainfall regime have led in the last decades to the extension of the agricultural areas affected by the drought phenomenon, both worldwide and in Romania. During the last half century, the drought and the phenomena associated with it, namely aridization and desertification, are a major problem for mankind. The limiting factor affecting field crops on the largest surface is the drought, the extent and intensity of this type of risk causing annual reduction of agricultural production by at least 30-50%. Drought represents the natural phenomenon determined by the amounts of precipitations below the normal values. The absence of rainfall is due to the predominance of the anti-cyclonic type. The most frequent phenomena occur in the extra-Carpathian agricultural regions of southern and south-eastern Romania Muntenia is located in the drought-sensitive area, where the influx of continental anti-cyclones is higher. Although this phenomena is possible in all seasons and in all agricultural areas, it doesn’t occur simultaneously and doesn’t have the same intensity. In the 21st century, the agricultural years 2001-2002, 2002-2003, 2006-2007, 2011-2012 and 2014-2015 are included in the list of the most recent years in terms of rainfall quantities, the heat units recorded in the warm season, as well as the soil moisture reserve available to winter wheat and maize plants during maximum water consumption. The objective of this paper is to highlight the correlation between the pluviometric regime analyzed during periods of maximum consumption of water from winter wheat and maize crops, the phenomenon of "heat" and the soil moisture reserve. The analysis of these specific indices helped us characterize the mentioned agricultural years, in the context of analysing the phenomenon of pedological drought with an impact in agriculture in Muntenia Region. An important element in the development of agricultural management strategies is to improve scientific knowledge and capacities to better manage climate variability by examining climate data and risks and opportunities analysis. The decrease in production of winter wheat and maize wheat crops occurs in extreme dry agricultural years due to the shortening of the vegetation season as a result of the increase in air temperature and water stress during the period of accumulation of the dry matter in the grain (the filling phase grain) caused by the reduction of precipitation amounts. Drought periods are increasingly common in Romania and are a major problem for agriculture with high impact on the agricultural production.
Effects of Some Herbal Plant Supplements on Growth Performance and the Immune Response in Nile Tilapia (Oreochromis Niloticus)
Authors: Hassan Ayman Abdel Mohsen , Yacout Mohamed Helmy , Khalel Mohamed Samir , Hafsa Salma Hashim Abu , Ibrahim Mostafa Abdel Rahman , Mocuta Dorina Nicoleta , Turek Rahoveanu Adrian , Dediu Lorena 
Published: September 2018

AbstractUsing of natural plants as immunostimulant in fish is more useful than antibacterial drugs that cause adversely side effects for fish, environment and consumers. Therefore, the present study was to investigate the effects of dietary turmeric (Curcuma longa), rosemary (Rosmarinus officinalis) and thyme (Thymus vulgaris) as feed additives on growth performance, proximate composition and some immuno-hematological parameters on Nile tilapia. Four nitrogenous (31.43-31.56 % crude protein) and isocaloric (17.90-18.04 kJ/g) diets were formulated to contain 0% (control), 1% of turmeric, rosemary or thyme, respectively. The results reveled that, supplementation with medicinal herbs significantly increased (P<0.05) weight gain, specific growth rates and protein efficiency ratio (PER) compared to those in the control group. Moreover, the medicinal herb additives had insignificant effect on carcass composition and some biochemical composition. Hematocrit and leukocrit levels in the fish fed with turmeric, rosemary and thyme added diet were found to be significantly (P <0.05) higher than the control group. However, leukocyte level among the experimental groups was not significantly differed (P >0.05). In neutrophils of experimental fish groups, there were higher numbers of NBT (+) cells fixed on lamellas than those of the control group. So, based on the current findings together with the low cost and the immunostimulative effect of turmeric, rosemary and thyme it can be recommended to be used in fish feed to minimize the mortalities caused by some pathogens.
Estimates of the Population Parameters and Exploitation Rate of Pontic Shad (Alosa Immaculata Bennett, 1835) in the Romanian Black Sea Coast
Authors: Tiganov George , Nenciu Magda-Ioana , Danilov Cristian Sorin , Nita Victor Nicolae 
Published: September 2018

Abstract
Sex ratio, morphometric characteristics, age and growth for Pontic shad from Romanian Black Sea Coast were examined. A total of 2.133 individuals were caught between March 2012 and September 2013. Female : male sex ratio was 0.62. According to the age reading, distribution varied form II to V year. The von Bertalanffy equation and growth performance index were determined by ESP software in Pontic shad. The asymptotic length (L∞ = L infinity) of Pontic shad generated by the ELEFAN I method, after introducing total length data for the two years of study, was 41.5. The natural mortality instantaneous coefficient (M) of the entire Pontic shad population, calculated according to Pauly’s empirical equation, using the growth parameters of the Von Bertalanffy formula and the mean annual temperature of the two study years of 13°C, recorded the following values: M = 0.585 in 2012 and M = 0.639 in 2013. According with the resultants, it is recommended to perform a sustainable fishing which allows the capture of legal-sized of fish.
First Outcomes of Grafting Wolfberry in Romania
Authors: Asănică Adrian , Hoza Dorel , Iacob Alexandru 
Published: September 2018

Abstract
Grafting berries is a topic untouched by researchers or practitioners till now in Romania due to the convenient and widely spread way of classic propagation methods. Nevertheless, the positive effect of grafted plants in commercial orchards is well known at many other species. Traits like precocity, uniformity, fruit size and yield stability is desired to be achieved in this manner. By grafting berries, we look forward to eliminate the actual shortcomings of the traditional crop systems, mainly generated by bushy crown shape that requires large distance between the plants, difficulties in mowing or weeding process along the rows, pruning and harvest operation in a uncomfortable arch position, discontinuous application of pesticides inside the bush etc. In this regard, different methods and trials have been conducted in the last two years at the University of Agronomic Sciences and Veterinary Medicine Bucharest in order to eliminate these bottlenecks in the berry technology trough grafted plants.
Control of Coffee Leaf Rust by Chitosan Oligomers and Propolis
Authors: Silva-Castro Iosody , Barreto Robert W. , Rodriguez M. Carmen H. , Matei Petruta M. , Martín-Gil Jesús 
Published: September 2018

Abstract
Broad scale use of chemical pesticides is known to have produced broad scale environmental impact worldwide and, at the same time, discovery and registration of new molecules to be used as insecticides, herbicides and fungicides have slowed significantly along the last decades, reducing the number of options for pest control by the farmers. Searches for novel environmentally friendly products are a recognized priority. In this work, aqueous solutions of chitosan oligomers (COs) and propolis (P), individually or as binary mixtures, were tested against Hemileia vastatrix, the fungus which causes coffee leaf rust, the worst disease of coffee. Germination of H. vastatrix was inhibited up toll 99 % by COs, followed by the mixture of COs-P and P individually (germination inhibition of 96 % and 54 % respectively). Testing those products on detached coffee leaf discs also produced promising results when COs were applied before H. vastatrix inoculation. These results may lead to the discovery of new antifungal products for the control of coffee leaf rust.
Study on the Potential of Winetourism in Alba County
Authors: Popa Andrada I. , Coros Monica M. 
Published: September 2018

Abstract
The present paper addresses an analysis of the economic, touristic and gastronomic evolution of the county starting from the period before the 1990s until 2016. Initially, the economic growth of Alba County started with its industry, especially the chemical, wood processing, machine building, and food industry, but also with mining. Afterwards, there was a period of economic decline, thereafter the industry in this area started to relaunch, however, below the 1990s level. The results of the study show the existence of many tourist attractions with great potential for growth and it also present the economic growth potential of Sebes, Cugir, Blaj, Alba Iulia, Rosia Montana, Zlatna, Ocna Mures, Arieseni and Aiud. The conclusions of the study highlight the need identified at county level, namely the necessity to turn into account the wine route by expanding accommodation capacities, taking advantage of the touristic objectives, developing the infrastructure and tailoring the offers