bluuebunny/crossref_metadata_2025_split huggingface dataset:
Heterotypic droplet formation by pro-inflammatory S100A9 and neurodegenerative disease-related alpha-synuclein
Authors: Veiveris Dominykas , Kopustas Aurimas , Sulskis Darius , Mikalauskaite Kamile , Tutkus Marijonas , Smirnovas Vytautas , Ziaunys Mantas 
Published: November 2024

AbstractLiquid-liquid phase separation (LLPS) of proteins and nucleic acids is a rapidly emerging field of study, aimed at understanding the process of biomolecular condensate formation and its role in cellular functions. LLPS has been shown to be responsible for the generation of promyelocytic leukemia protein bodies, stress granules, and intrinsically disordered protein condensates. Recently, it has been discovered that different neurodegenerative disease-related proteins, such as alpha-synuclein (related to Parkinson’s disease) and amyloid-beta (Alzheimer’s disease) are capable of forming heterotypic droplets. Other reports have also shown non-LLPS cross-interactions between various amyloidogenic proteins and the resulting influence on their amyloid fibril formation. This includes the new discovery of pro-inflammatory S100A9 affecting the aggregation of both amyloid-beta, as well as alpha-synuclein. Combined, these observations suggest that protein interactions during LLPS and heterotypic droplet formation may be a critical step in the onset of neurodegenerative diseases.In this study, we explore the formation of heterotypic droplets by S100A9 and alpha-synuclein using a range of different spectroscopic and microscopic techniques. We show that the protein mixture is capable of assembling into both homotypic, as well as heterotypic condensates and that this cross-interaction alters the aggregation mechanism of alpha-synuclein. In addition, it also stabilizes a specific fibril conformation, which has a higher propensity for self-replication. These results provide insight into the influence of S100A9 on the process of neurodegenerative disease-related protein LLPS and aggregation, bringing us one step closer to developing a potential cure or treatment modality.
Dynamic consensus-building between neocortical areas via long-range connections
Authors: Javadzadeh Mitra , Schimel Marine , Hofer Sonja B. , Ahmadian Yashar , Hennequin Guillaume 
Published: November 2024

AbstractThe neocortex is organized into functionally specialized areas. While the functions and underlying neural circuitry of individual neocortical areas are well studied, it is unclear how these regions operate collectively to form percepts and implement cognitive processes. In particular, it remains unknown how distributed, potentially conflicting computations can be reconciled. Here we show that the reciprocal excitatory connections between cortical areas orchestrate neural dynamics to facilitate the gradual emergence of a ‘consensus’ across areas. We investigated the joint neural dynamics of primary (V1) and higher-order lateromedial (LM) visual areas in mice, using simultaneous multi-area electrophysiological recordings along with focal optogenetic perturbations to causally manipulate neural activity. We combined mechanistic circuit modeling with state-of-the-art data-driven nonlinear system identification, to construct biologically-constrained latent circuit models of the data that we could further interrogate. This approach revealed that long-range, reciprocal excitatory connections between V1 and LM implement an approximate line attractor in their joint dynamics, which promotes activity patterns encoding the presence of the stimulus consistently across the two areas. Further theoretical analyses revealed that the emergence of line attractor dynamics is a signature of a more general principle governing multi-area network dynamics: reciprocal inter-area excitatory connections reshape the dynamical landscape of the network, specifically slowing down the decay of activity patterns that encode stimulus features congruently across areas, while accelerating the decay of inconsistent patterns. This selective dynamic amplification leads to the emergence of multi-dimensional consensus between cortical areas about various stimulus features. Our analytical framework further predicted the timescales of specific activity patterns across areas, which we directly verified in our data. Therefore, by linking the anatomical organization of inter-area connections to the features they reconcile across areas, our work introduces a general theory of multi-area computation.
Distinguishing the activity of adjacent somatosensory nuclei within the brainstem using 3T fMRI
Authors: Howell Paige , Odermatt Ingrid , Harrison Olivia , Rabe Finn , Meissner Sarah , Freund Patrick , Wenderoth Nicole , Kikkert Sanne 
Published: November 2024

AbstractExperimental evidence in animal models indicates that the brainstem plays a major role in sensory modulation. However, mapping functional activity within the human brainstem presents many methodological challenges. These constraints have deterred essential research into human sensory brainstem processing. Here, using a 3T fMRI sequence optimised for the brainstem, combined with uni- and multivariate analysis approaches, we investigated the extent to which functional activity of neighbouring somatosensory nuclei can be delineated in the brainstem, thalamus and primary somatosensory cortex (S1). Whilst traditional univariate approaches offered limited differentiation between adjacent hand and face activation in the brainstem, multivariate classification enabled above-chance decoding of these activity patterns across S1, the thalamus, and the brainstem. Our findings establish a robust methodological approach to explore signal processing within the brainstem and across the entire somatosensory stream. This is a fundamental step towards broadening our understanding of somatosensory processing within humans and determining what changes in sensory integration may occur in clinical populations following sensory deprivation.
The role of cholinergic signaling in multi-sensory gamma stimulation induced perivascular clearance of amyloid
Authors: Lavoie Nicolas , Blanco-Duque Cristina , Kahn Martin , Nawaid Hiba , Loon Anjanet , Seguin Alexander , Raju Ravikiran , Davison Alexis , Yang Cheng-yi , Tsai Li-Huei 
Published: November 2024

ABSTRACTModulatory neurotransmitters exert powerful control over neurons and the brain vasculature. Gamma Entrainment Using Sensory Stimuli (GENUS) promotes amyloid clearance via increased perivascular cerebral spinal fluid (CSF) flux in mouse models of Alzheimer’s Disease. Here we use whole-brain activity mapping to identify the cholinergic basal forebrain as a key region responding to GENUS. In line with this, GENUS promoted cortical acetylcholine release, vascular dilation, vasomotion and perivascular clearance. Inhibiting cholinergic signaling abolished the effects of GENUS, including the promotion of arterial pulsatility, periarterial CSF influx, and the reduction of cortical amyloid levels. Our findings establish cholinergic signaling as an essential component of the brain’s ability to promote perivascular amyloid clearance via non-invasive sensory stimulation.
An automatic domain-general error signal is shared across tasks and predicts confidence in different sensory modalities
Authors: Davidson Matthew , Aiyer Sriraj , Yeung Nick 
Published: November 2024

AbstractUnderstanding the ability to self-evaluate decisions is an active area of research. This research has primarily focused on the neural correlates of self-evaluation during visual-tasks, and whether pre- or post-decisional neural correlates capture subjective confidence in that decision. This focus has been useful, yet also precludes an investigation of key every-day features of metacognitive self-evaluation: that decisions are rapid, must be evaluated without explicit feedback, and unfold in a multisensory world. These considerations lead us to hypothesise that an automatic domain-general metacognitive signal may be shared between sensory modalities, which we tested in the present study with multivariate decoding of electroencephalographic (EEG) data. Participants (N=21, 12 female) first performed a visual task with no request for self-evaluations of performance, prior to an auditory task that included rating decision confidence on each trial. A multivariate classifier trained to predict errors in the speeded visual-task generalised to predict errors in the subsequent non-speeded auditory discrimination. This generalisation was unique to classifiers trained on the visual response-locked data, and further predicted subjective confidence on the subsequent auditory task. This evidence of overlapping neural activity across the two tasks provides evidence for automatic encoding of confidence independent of any explicit request for metacognitive reports, and a shared basis for metacognitive evaluations across sensory modalities.
Awareness of the future: Dolphins know when they need to remember for the future
Authors: Ortiz Sara Torres , Smeele Simeon Q. , Osvath Mathias , Guerrero Andrea Martín , Sanchez Ariana Hernandez , Ramirez Cristina Ubero , Almunia Javier , von Bayern Auguste M. P. 
Published: November 2024

AbstractIn humans, awareness of an upcoming memory test enhances intentional encoding and improves memory recall. Here, we investigated whether dolphins exhibit similar future-oriented encoding of information known to be needed in the future. Dolphins were trained to remember specific, randomly assigned actions for later re-enactment, with either immediate or delayed recall. When an unexpected delay was introduced in trials anticipating immediate recall, memory was retained for only 13 seconds, suggesting working memory encoding. However, when instructed to expect delayed recall, dolphins accurately reproduced actions after delays even after 16 hours. These results suggest that dolphins, anticipating future need, intentionally encode actions to be performed in the future into long-term memory, implying prospective encoding and prospective memory capacities. Their memory also displayed key features of episodic memory: encoding occurred in a single episode, and memory was declarative, as the action itself declared its content. Moreover, dolphins more effectively recalled self-performed actions compared to gestural codifications of the same actions, mirroring the human-typical “enactment effect” and supporting episodic-like memory over semantic memory. Our findings indicate that dolphins show awareness of future memory demands and seem to use a future-oriented, episodic-like memory system, capable of storing prospectively encoded, intended actions in long-term memory.
Planning-while-acting: addressing the continuous dynamics of planning and action in a sequential embodied task
Authors: Nuzzi Davide , Cisek Paul , Pezzulo Giovanni 
Published: November 2024

AbstractEveryday tasks, such as selecting routes when driving or preparing meals require making sequences of embodied decisions, in which planning and action processes are intertwined. In this study, we address how people make sequential embodied decisions, requiring balancing between immediate affordances and long-term utilities of alternative action plans. We designed a novel game-like task in which participants controlled an avatar tasked with “crossing rivers”, by jumping across rocks. The task permitted us to assess how participants balanced between immediate jumping affordances (“safe” versus “risky” jumps) and the utility (length) of the ensuing paths to the goal. Behavioral and computational analyses revealed that participants planned ahead their path to the goal rather than simply focusing on the most immediate jumping affordances. Furthermore, embodied components of the task influenced participants’ decision strategies, as evident by the fact that participants’ current direction of movement influenced their choice between safe and risky jumps. We also found that participants showed (pre)planning before making the first jump, but they continued deliberating during it, with movement speed decreasing at decision points and when approaching them. Finally, computational modeling indicates that farsighted participants who assigned greater weight to the utility of future jumps showed a better performance, highlighting the usefulness of planning in embodied settings. Our findings underscore the importance of studying decision-making and planning in ecologically valid, embodied settings, providing new insights into the interplay between action and cognition in real-world planning-while-acting scenarios.
Exploring dynamic customer requirement trend of buffet restaurant: a two-stage analysis from online reviews
Authors: Shen Zifan , Li Yanlai , Wang Shouyang , Zhao Cuiming 
Published: November 2024

PurposeCustomer expectations and preferences may evolve as they experience more. This study aims to analyze the dynamics of customer requirements (CRs) as customer experience familiarity increases, offering insights for enhancing product-service quality.Design/methodology/approachThis study categorizes dynamic requirements into two conversion stages: from new to repeat customers and from repeat to frequent customers. First, crawl online reviews (ORs) and determine each review’s conversion stage. Second, identify product-service attributes from reviews and conduct aspect-level sentiment analysis. Then, examine each attribute’s trend direction and magnitudes in the two stages. Finally, a dynamic-trend importance-performance analysis (DTIPA) model is developed to analyze the dynamic requirements and provide strategies for optimizing product services.FindingsThis study identifies eight attributes of buffet restaurants with varying requirement change trends. In particular, customer attention to “waiting time,” “variety of dishes,” “cost performance” and “taste” decreases in the first stage. In the second stage, “environment” and “freshness” increase differently from the first. Satisfaction with “cost performance” increases in the first stage but decreases in the perception of frequent customers. Improvement strategies are also provided based on these trends.Originality/valueResearch on dynamic requirement trends based on ORs and customer experience familiarity is scarce, particularly in the context of buffet restaurants. Moreover, existing methods have their limitations. This study proposes a novel approach for the progressive exploration and extraction of evolving CRs from ORs. By incorporating the trend direction and magnitude of attributes’ importance and satisfaction, DTIPA is developed to form strategies for optimizing buffet restaurant product services.
The effect of volition and memory distrust on eyewitness suggestiblity
Authors: Barnoth Ditte , Brown Scott , Saraiva Renan , Wagner Marlena , Cullen Hayley Joanne 
Published: November 2024

Purpose
Post-event information (PEI) may distort eyewitness memory and lead to erroneous eyewitness testimonies. This paper aims to explore whether factors such as volitional engagement with PEI (e.g. choice to engage with a co-witness) and memory distrust influence misinformation acceptance and the perceived credibility of a co-witness.

Design/methodology/approach
Participants (n = 223) completed the Memory Distrust Scale and then watched a short mock crime video. Thereafter, two-thirds of the participants were asked whether they would prefer or not to listen to a co-witness’ account of the witnessed event (choice condition), and one-third of the participants did not have the choice (control condition). Every participant listened to the co-witness account (which contained items of misinformation); thus, those who preferred to listen to the testimony were in the choice-yes (i.e., volition) condition and those who preferred not to listen were in the choice-no (i.e., non-volition) condition. Finally, participants completed a cued recall task assessing their memory of the video and acceptance of misinformation. They also provided ratings to establish the perceived credibility of the co-witness.

Findings
The results indicated that neither volition nor memory distrust influenced misinformation acceptance. However, those who preferred to listen to the testimony (i.e., the choice-yes condition) perceived the co-witness as more credible than those in the choice-no or control conditions.

Practical implications
The findings suggest that witnesses are susceptible to misinformation regardless of their willingness to engage with or avoid PEI. Further implications and future research directions are discussed.

Originality/value
To the best of the authors’ knowledge, this study is the first to investigate the role of volition and memory distrust as a trait in eyewitnesses tendency to engage with or avoid post-event information. The research explores whether these mechanisms impact upon memory conformity and perceived co-witness credibility.
Distinguishing fashion consciousness from fashion involvement: review and survey
Authors: Büttner Ana Julia , Strehlau Suzane 
Published: November 2024

PurposeDespite the large corpus of literature on fashion consciousness (FC) and fashion involvement (FI), both terms are often used synonymously, resulting in conflicting or mixed results. We address this limitation by offering a critical analysis of FC and FI, with a specific focus on their measurements.Design/methodology/approachA snowball sample survey of 720 respondents were conducted for factor analysis aimed at assessing reliability and validity. Specifically, following discriminant and concurrent validity between FC and FI.FindingsOur empirical research underscores the clear distinction between FC and FI in terms of their theoretical definitions and measurements. We strongly discourage their use as interchangeable/synonymous terms or use of other potentially related terminology.Originality/valueOur contribution clarifies the differences between FI and FC. While acknowledging that authors may resort to linguistic repetition in their discourse, we advocate for consistently using the precise terms “fashion involvement” and “fashion consciousness” whenever feasible. This study has the potential to inform future knowledge development and literature reviews in the field.
Enhancing digital intelligence among Thai seniors: developing and validating the digital intelligence quotient scale
Authors: Wiroonrath Sirinya , Na-Nan Khahan , Inmor Sureerut , Thammarakkitanon Vipaspon 
Published: November 2024

PurposeThe purpose of this study is to develop and validate a digital intelligence quotient (DIQ) scale specifically designed to assess cognitive and socio-emotional competencies among the elderly population in Thailand. The study aims to enhance the understanding of digital intelligence within this demographic and provide a practical tool for researchers and practitioners in the fields of gerontology and digital literacy.Design/methodology/approachThe study employed a multi-phase approach, beginning with the formulation of 34 questions based on established DIQ concepts and theories. These questions underwent exploratory factor analysis (EFA) for initial validation, followed by confirmatory factor analysis (CFA) and assessments of convergent validity. The final DIQ scale was tested with a sample of 400 elderly participants in Thailand, ensuring both content and construct validity.FindingsThe EFA identified eight dimensions of DIQ: digital identity, digital use, digital safety, digital security, digital emotional intelligence, digital communication, digital literacy and digital rights. The CFA confirmed the consistency of these dimensions with empirical data, resulting in a reliable and valid instrument for assessing digital intelligence among the elderly. The study highlights the importance of these competencies in navigating the digital landscape and addressing the unique challenges faced by older adults.Originality/valueThis study provides a novel and comprehensive instrument for assessing digital intelligence among the elderly, contributing to the theoretical understanding of digital competencies in this demographic. The DIQ scale offers valuable insights for designing tailored interventions and digital literacy programs, promoting digital resilience and knowledge among older adults. This research addresses a critical gap in the literature and has practical implications for enhancing digital inclusion and safety for the elderly.
Innovative methods of management and control of financial audit by enterprises in the conditions of war (remote work)
Authors: Yaroshenko Oleg M. , Nastyuk Vasyl Ya , Koliesnik Tetiana V. , Klemparskyi Mykola M. , Tsybulnyk Nelli Yu 
Published: November 2024

PurposeThe article examines the specifics of conducting a financial audit by enterprises through innovative methods of management and control, especially under martial law and remote work.Design/methodology/approachThe authors study the draft laws aimed at improving the conduct of financial audits under martial law.FindingsThe advantages and prospects for the introduction of electronic audits in Ukraine are analyzed. The need to introduce electronic audits and outsourcing audits as one of the methods of reducing the impact of war on the Ukrainian economy is determined.Practical implicationsA number of measures are proposed to improve management and control of financial audits during the war and implement e-audit in the traditional system of taxpayer audits and activities. The audit in the context of remote work and war can no longer be conducted by traditional methods. It is specified that the main form of audit is a remote audit, which, despite the limitations, should be conducted in accordance with established international standards.Originality/valueFinally, it is proposed to clarify the structure of specialized tax audit in Ukraine, create an electronic audit procedure and develop appropriate software for auditors.
Sneakerheads for Trump: information flows in the online news media
Authors: Dubois Derek 
Published: November 2024

PurposeThis paper explores information flows in the news media amid ideological polarization, focusing on challenges and opportunities. The case study of Donald Trump’s sneaker line unveiling examines how news agencies navigate objectivity in reporting politically sensitive topics online. It also explores the balance news supply chains must strike between expediency, objectivity and differentiation for diverse audiences.Design/methodology/approachThe study conducts qualitative and quantitative content analysis on mainstream media coverage of Donald Trump’s sneaker unveiling. Meticulous coding and inductive approaches systematically review news stories to uncover trends and variations. Incorporating media bias ratings provides context on potential framing biases. This rigorous methodology aims to locate emergent themes in how news outlets interpret and report on politically charged events, offering reliable insights into the dynamics of reporting on contentious narratives.FindingsThe analysis reveals polarized reactions to Trump’s sneaker unveiling, reflecting societal divisions. Aesthetics underscore manipulative political messaging and ethical dilemmas. Varying press reception mirrors broader tensions across online news media. Coverage suggests a link between media bias and sentiment toward Trump. Theoretical insights explore dynamic capabilities and social identity theory. The study offers practical implications for navigating ideological framing and audience engagement, benefiting news media supply chain professionals.Originality/valueThis paper provides novel insights into online news supply chains, revealing complexities in reporting politically charged events. It contributes theoretical perspectives on dynamic capabilities and social identity theory and offers practical implications for managing ideological framing in online news media, adding significantly to existing knowledge.Peer reviewThe peer review history for this article is available at: https://publons.com/publon/10.1108/OIR-04-2024-0241