bluuebunny/crossref_metadata_2025_split huggingface dataset:
Smart cities and enabling technologies: influences on urban Facility Management services
Authors: Talamo C , Pinto M R , Viola S , Atta N 
Published: July 2019

Abstract
The application of innovative Information and Communication Technologies (ICTs) to the field of Urban Facility Management (UFM) outlines new possibilities for optimizing existing services and for developing new services based on the key concepts of: Internet of Things (IoT), Big Data, information sharing and smart applications. Such ICT-based services could potentially be able to: transform the demand for infrastructures and physical assets; participate to requalification processes; influence the sustainability of the built environment as well as the economic value of urban areas. Starting from this premise, the paper deals with the contents and the current results of an ongoing research whose aim is to propose sets of classification and coding rules and a framework for identifying, analysing and linking Smart Cities (SC) domains and sub-domains, related UFM services and the various levels of enabling ICT technologies. The application of the proposed framework to a selected representative sample made up by both European Initiatives (e.g. H2020 projects) involved with SC solutions at the urban scale and virtuous cases of cities that have implemented smart solutions, allows to collect, allocate and process information, in a unified way, in order to:
• identify and describe the current main trends within each of the SC domains (e.g. mobility, energy, waste, building, governance) and sub-domains;
• implement a taxonomy of UFM services, including related characterising parameters and stakeholders;
• identify and analyse, according to reading keys, smart UFM services that may have meaningful impacts (accessibility, transport, land-use, etc.) on urban areas;
• draw the current innovative scenarios of smart UFM services enabled by ICTs, characterized by information sharing (Big Data flows) and by the integration of physical and digital infrastructures and assets;
• highlight the emerging and widespread enabling technologies for smart UFM services, related to each of the layers of the technological infrastructure (e.g. sensing, network, platform, analytics, applications);
• investigate the possibility of the creation of context-aware communities through the inclusion of multiple social components.
The research, which is part of the PRIN research “Metropolitan cities: economic-territorial strategies, financial constraints and circular regeneration”, aims at providing interpretive keys and structured information, useful to study, evaluate and compare possible influences and impacts of the smart UFM services on the sustainability of the urban environment and on the dynamics of property values. The scenario that emerges from the analysis is inscribed in the broader framework of the circular economy where, with the support of ICTs -based services, cities can put in place virtuous processes to reduce, recycle and reuse waste.
Localizing the SDGs through tailored-based training solutions targeting students and academics
Authors: Fernandez G , Maione C 
Published: July 2019

Abstract
This paper focuses on understanding, education, and knowledge gaps on topics related to sustainable development such as urban metabolism, responsible use of natural resources, and the United Nations Sustainable Development Goals (SDGs). This work is part of a broader study that aims at disseminating education on topics at all level of societies, including minority groups such as children, elderly, persons with disabilities, students and academics, women, LGBTI+, and homeless and refugees. The current study tackles students and academics specifically and illustrates the relationship between cultural background (country and continent of origin) and perceptions of sustainable development and politics at the local level. For this analysis, data were analysed and collected at the Politecnico di Milano, Milan (Italy) using structured interviews and survey questionnaires. Findings provide a deeper understanding of students and academic sensitivities of SDGs and local political system spatial patterns by continent across the world.
BIMReL: a new BIM object library using Construction Product Regulation attributes (CPR 350/11; ZA annex)
Authors: Pavan A , Mirarchi C , Amosso G , Nesa L Meherun , Pasini D , Daniotti B , Spagnolo S Lupica 
Published: July 2019

Abstract
The digitalisation of construction sector introduces opportunities for all the actors of AEC chain. Using the virtualisation of real entities, with models of buildings, infrastructures or of the environment (BIM: Building Information Model), it could be possible to simulate the sustainability of new property developments or renewal ones (capex/opex; BS PAS 1192-2-3 [1] [2]). With the object-oriented programming, the new ICT tools for AEC sector can rework on the data themselves, with the classes and attributes they have “learned”. At the beginning, the typology of classes and attributes were defined in BIM authoring software. To complete all the information required for every different use, the actors can find other attributes (of objects) they may need in other database existing on the market. These extended attributes could be linked to the BIM authoring objects to complete their functionality in all phases of the construction process. Thus, all the attributes of each object are now defined by the software houses, by public or private organisations (and their BIM tools) or by every single manufacturer company. However, there isn’t an international standard other than the Italian UNI 11337-3:2015 [3]. To improve this status quo, increase the implementation of sustainability simulation and life cycling data management in AEC process, it is necessary to define a new specific technical standard of BIM object attributes. BIMReL is the first BIM object library that uses the common information structure and the essential characteristics for CE mark of CPR 350/2011 (Construction Product Regulation) [4], to define the attributes of the virtual objects like the real products. The architecture of BIMReL is based on the data structure of newly released Italian standard UNI 11337-3 (2019) and, as a consequence, part of the EN draft standard at European CEN 442 Technical Committee (WG 4).
Energy and comfort management of the educational spaces through IoT network for IAQ assessment in the eLUX lab
Authors: Tagliabue L C , Cecconi F Re , Rinaldi S , Flammini A , Ciribini A L C 
Published: July 2019

Abstract
IoT networks for data gathering in the buildings allow to control and manage the operational phase of the systems for ventilation and IAQ, optimizing the energy flows and the indoor comfort conditions. The concept of Cognitive Building steers the implementation of such networks in the assets considering the sensors as scattered systems to inform and actuate the adaptation strategies which are crucial when variables have to be included in the process management. Variables as weather, occupancy flows during the day, energy production by renewable energies, energy storage strategies, affect the indoor conditions, the rate of use of the HVAC systems and the energy management of the used/storage resources. The eLUX lab at the Smart Campus of the University of Brescia is a pilot building in the field and it has been monitoring since 2017. The indoor conditions monitoring could unveil critical situations defined by temperature, humidity and indoor air quality (IAQ) in the educational spaces and envisage strategies and scenarios related to energy demand defined by the occupancy stream. The IoT network collects data about indoor air quality in the different spaces and it is used to verify and increase the accuracy on occupancy estimation. The HVAC management referred to the effective occupancy can enable an energy management process based on user-centred approach empowering an increment of the comfort hours facing critical situations and it is possible to promote actuation strategies preserving energy efficiency and IAQ (e.g. increase ventilation to decrease the CO2 concentration, decrease temperature and control relative humidity in the indoor spaces by window opening or modulation of the fans and dehumidification systems activation). The educational spaces have been adopted as case studies to analyse the actual indoor conditions and come up with a detailed description of the profiles of use (i.e. occupancy, lighting, equipment, HVAC, CO2) supporting effective management policies. The paper describes the analyses on the data collected to understand when and how the indoor conditions can be improved to preserve the learning performance of the users. The research addresses one of the main topics of the eLUX living lab.
A framework for the optimisation of glazed gridshells in the early design stage under structural and energy-based criteria
Authors: Pagnacco T , Masera G , Weilandt A , Baldassini N 
Published: July 2019

Abstract
While it is of primary importance to deliver high performance architecture within constraints of time and money, the integration between structural and energy-based aspects presents significant challenges for the organisation of the design process, especially in the early stages. In the case of complex envelopes, such as glazed gridshells, these engineering-related aspects should be considered from multiple points of view from the very beginning of the concept development, exploiting the potential conflicts between architects and engineers to let creative solutions emerge, and thus avoiding expensive and time-consuming design modifications downstream. This paper aims to define the framework required to integrate a multi-objective optimisation capable of combining such aspects into an integrated flow of information. Such an integrated analysis presents difficulties because, in the early design phases, conceptual changes happen faster than computational capacity; so, to overcome this obstacle it is necessary to define an iterative flow of information between structural and energy-based procedures, while at the same time taking into account the aesthetic requirements. This particular flow not only guarantees a correct passage of technical data among different software tools, but it also allows for a better communication and comprehension of information between diverse actors, such as architects and engineers. Based on this specific plan, a conceptual framework for optimising gridshells under structural, geometrical and energy-based criteria is developed and presented. The final goal of such a procedure is not, clearly, to replace the designer, but to give guidance to transform potential conflict into creative discussion and improve the efficiency of the later phases of the design process.
The Significance of Trans-Epidermal Water Loss After Microneedling and Microneedling-Radiofrequency Procedures: Histological and IRB-Approved Safety Study
Authors: Sasaki Gordon H 
Published: July 2019

Abstract

Background
Microneedling (MN) and microneedling-radiofrequency (MN-RF) result in skin rejuvenation and skin exposure to pathogens.

Objectives
The aim was to determine histopathological changes of needle-depth injuries in preauricular skin and measure time-dependent repair of transepidermal water loss (TEWL) in subjects.

Methods
MN and MN-RF procedures were performed at 0.5- and 1.5-mm needle depths on preauricular skin strips from a facelift patient. In 10 subjects, MN and MN-RF procedures were performed at 0.5-mm needle lengths on 6 marked opposing face and body sites. MN and MN-RF at 1.5-mm needle lengths were also carried out on each subject’s midface skin lateral to the nasolabial fold. TEWL measurements were recorded with a calibrated DermaLab Cortex device (Hadsund, Denmark).

Results
Histological examination confirmed that the penetration depths of microchannels closely approximated the 0.5- or 1.5-mm needle lengths. In addition, MN-RF exhibited zones of coagulation injury at the distal end of the channel. After MN or MN-RF at 0.5-mm needle length, TEWL values were greatest immediately after needling to scalp, midface, neck, chest, arm, and thigh sites and remained slightly higher than baseline throughout the 48-h evaluation period. TEWL measurements after MN or MN-RF at 1.5-mm needle length resulted in the highest- and longest-lasting values throughout the 2-day observation period.

Conclusions
MN and MN-RF devices are novel devices that require further investigation into optimal treatment parameters and protocols, patient selection, and protection against intrusion of external pathogens and reactive cosmeceutical ingredients with barrier repair.

Level of Evidence: 2
Talkin’ Bout iGeneration: A New Era of Individualistic Social Work Practice?
Authors: Fenton Jane 
Published: July 2019

AbstractThis article considers the impact of generational changes on the new cohort of social work students most of whom were born post-1995, and therefore belong to ‘iGeneration’ (iGen).This article is especially concerned with the finding that the generation before iGen is more right-wing authoritarian than all post-war generations and what this might mean for the future of social work should that trajectory continue. A study was undertaken to examine the attitudes of 122 iGen students in first-year university course in Scotland. Results show that mean attitudinal measures were right-wing authoritarian in relation to crime and punishment and to unemployed people. Social work students aligned more in their attitudes with their primary education colleagues and less with their less authoritarian community education colleagues, and, overall, the iGen cohort was significantly more right-wing authoritarian than their older colleagues. In essence, there was evidence to suggest that an individualistic, self-sufficiency neoliberal narrative had been quite profoundly internalised by the iGen cohort of students. Implications of a new individualistic practice are considered, and suggestions for social work education programmes are made.
FBXW10 promotes hepatocarcinogenesis in male patients and mice
Authors: Luo Yuan-Deng , Zhang Jie , Fang Lei , Zhu Yan-Yin , You Yue-Mei , Zhang Cheng-Cheng , Zheng Ping , Zhang Lei-Da , Yin Liang-Yu , Xia Feng , Bie Ping , Xie Chuan-Ming 
Published: July 2019

Abstract
Hepatocellular carcinoma (HCC) is reported to associate with abnormal expression of SCF E3 ubiquitin ligases. FBXW10, an F-box protein of the E3 ubiquitin ligases, was abnormally regulated in HCC patients. However, whether FBXW10 is associated with HCC has not yet been evaluated. Here, we analyzed the associations between overall survival and various risk factors in 191 HCC tissues. Univariate and multivariate analyses demonstrated that FBXW10 was an independent risk factor related to HCC prognosis. The results showed that FBXW10, gender and tumor state were strongly associated with overall survival in HCC patients. Furthermore, high expression of FBXW10 was associated with poor survival among male HCC patients but not female HCC patients. FBXW10 was more highly expressed in male HCC tissues and more strongly related to vascular invasion in male HCC patients. Consistent with these findings, the male FBXW10-Tg(+) mice were more susceptible to tumorigenesis, changes in regenerative capacity, and liver injury and inflammation but not changes in liver function than FBXW10-Tg(–) mice. FBXW10 promoted cell proliferation and migration in HCC cell lines. Our findings reveal that FBXW10, an independent risk factor for HCC, promotes hepatocarcinogenesis in male patients, and is also a potential prognostic marker in male patients with HCC.
Taste Responsiveness of Spider Monkeys to Dietary Ethanol
Authors: Dausch Ibañez Daniel , Hernandez Salazar Laura Teresa , Laska Matthias 
Published: July 2019

AbstractRecent studies suggest that frugivorous primates might display a preference for the ethanol produced by microbia in overripe, fermenting fruit as an additional source of calories. We, therefore, assessed the taste responsiveness of 8 spider monkeys (Ateles geoffroyi) to the range of ethanol concentrations found in overripe, fermenting fruit (0.05–3.0%) and determined taste preference thresholds as well as relative taste preferences for ethanol presented in sucrose solutions and in fruit matrices, respectively. Using a 2-bottle preference test of short duration (1 min), we found that spider monkeys are able to detect ethanol concentrations as low as 0.5%, that they prefer ethanol concentrations up to 3% over water, and that they prefer sucrose solutions and pureed fruit spiked with ethanol over equimolar sucrose solutions and pureed fruit without ethanol. However, when presented with an ethanol-spiked sucrose solution and a higher-concentrated sucrose solution without ethanol, the animals clearly preferred the latter, even when the sucrose–ethanol mixture contained 3 times more calories. These results demonstrate that spider monkeys are more sensitive to the taste of ethanol than rats and humans and that they prefer ecologically relevant suprathreshold concentrations of ethanol over water. Tests with sucrose solutions and pureed fruits that were either spiked with ethanol or not suggest that sweetness may be more important for the preferences displayed by the spider monkeys than the calories provided by ethanol. The present results, therefore, do not support the notion that dietary ethanol might be used by frugivorous primates as a supplemental source of calories.
Toxin A–Predominant Pathogenic Clostridioides difficile: A Novel Clinical Phenotype
Authors: Lin Qianyun , Pollock Nira R , Banz Alice , Lantz Aude , Xu Hua , Gu Limei , Gerding Dale N , Garey Kevin W , Gonzales-Luna Anne J , Zhao Mingwei , Song Linan , Duffy David C , Kelly Ciaran P , Chen Xinhua 
Published: July 2019

Abstract

Background
Most Clostridioides difficile toxinogenic strains produce both toxins A and B (A+B+), but toxin A–negative, toxin B–positive (A−B+) variants also cause disease. We report the identification of a series of pathogenic clinical C. difficile isolates that produce high amounts of toxin A with low or nondetectable toxin B.

Methods
An ultrasensitive, quantitative immunoassay was used to measure toxins A and B in stool samples from 187 C. difficile infection (CDI) patients and 44 carriers. Isolates were cultured and assessed for in vitro toxin production and in vivo phenotypes (mouse CDI model).

Results
There were 7 CDI patients and 6 carriers who had stools with detectable toxin A (TcdA, range 23–17 422 pg/mL; 5.6% of samples overall) but toxin B (TcdB) below the clinical detection limit (&lt;20 pg/mL; median TcdA:B ratio 17.93). Concentrations of toxin A far exceeded B in in vitro cultures of all 12 recovered isolates (median TcdA:B ratio 26). Of 8 toxin A&gt;&gt;B isolates tested in mice, 4 caused diarrhea, and 3 of those 4 caused lethal disease. Ribotyping demonstrated strain diversity. TcdA-predominant samples were also identified at 2 other centers, with similar frequencies (7.5% and 6.8%).

Conclusions
We report the discovery of clinical pathogenic C. difficile strains that produce high levels of toxin A but minimal or no toxin B. This pattern of toxin production is not rare (&gt;5% of isolates) and is consistently observed in vitro and in vivo in humans and mice. Our study highlights the significance of toxin A in human CDI pathogenesis and has important implications for CDI diagnosis, treatment, and vaccine development.
To Succeed, One Health Must Win Animal Agriculture’s Stronger Collaboration
Authors: Gray Gregory C , Mazet Jonna A K 
Published: July 2019

Abstract
The One Health approach has received widespread international endorsements from professional, academic, and governmental organizations as the way forward in tackling complex interdisciplinary problems, such as emerging zoonotic diseases, antimicrobial resistance, and food safety. Yet conspicuously absent from US One Health training or research activities are the animal agricultural industries. Their absence is likely due to multiple factors, including the lack of appreciation for their potential problem-solving roles, as well as the industries’ business-oriented fears that such engagement could cause them to suffer economic damage. As demands on the swine, poultry, egg, beef, and dairy production industries are closely linked to the above-mentioned complex problems, we must find new, nonthreatening ways to better engage and win animal agriculture’s collaboration into One Health training and research partnerships for successful health problem solving. Without animal agricultural industries’ improved cooperation, One Health’s efforts to control these complex problems are not likely to succeed.
Minimizing Bee (Hymenoptera: Apoidea) Bycatch in Japanese Beetle Traps
Authors: Sipolski Steven J , Datson Sara W , Reding Michael , Oliver Jason B , Alm Steven R 
Published: July 2019

Abstract
Native and introduced bees were attracted to and captured in commercially available Japanese beetle, Popillia japonica Newman (Coleoptera: Scarabaeidae), traps baited with floral lure components: geraniol, eugenol, and phenethyl propionate [PEP] in Rhode Island, Ohio, and Tennessee. Studies in Rhode Island showed that Bombus impatiens Cresson (Hymenoptera: Apidae) was significantly more attracted to geraniol alone and as a component in floral lure blends than to either eugenol or PEP alone. Xylocopa virginica (L.) (Hymenoptera: Apidae) was more selective in being primarily attracted to traps baited with higher amounts of geraniol in 2016. Removing geraniol from the floral lure blend did not significantly reduce Japanese beetle captures in 2017 and 2018 in Rhode Island and Ohio but did significantly reduce bee captures in Rhode Island in 2017 and 2018. Green, black, brown, and red traps captured significantly fewer bees than clear or standard yellow vane and green cage traps in 2018 in Rhode Island and Tennessee; however, there were no significant differences between Japanese beetle captures in any of the colored or clear traps. Our results show that using all green traps with a lure composed of eugenol and PEP and the Japanese beetle female produced sex pheromone can effectively capture Japanese beetles while minimizing bycatch of bees.
Three female patients with Danon disease presenting with predominant cardiac phenotype: a case series
Authors: Mulder Bart A , Hoedemaekers Yvonne M , van den Berg Maarten P , van Loon Rosa L E , Wind Anna M , Jongbloed Jan D H , Wiesfeld Ans C P 
Published: July 2019

AbstractBackgroundDanon disease is a rare X-linked multisystemic disorder that has primarily been described in male patients.Case summaryWe present three female patients with Danon disease with a predominantly cardiac phenotype in whom disease onset and expression was very different from that of male patients. Case 1 was first admitted for acute heart failure and then readmitted a few months later for cardiac shock, necessitating mechanical support, and heart transplantation. Case 2 had complex arrhythmias for which many antiarrhythmic drugs were tried with only limited success. Her disease accelerated after her first pregnancy, and she showed reduced left ventricular function and dilated cardiomyopathy. Case 3 was referred for near syncope and ablated for an accessory pathway; she had extensive left ventricular hypertrophy. In all three cases, a final diagnosis of Danon disease was only made after genetic testing that identified a causal variant in the lysosome-associated membrane protein 2 gene.DiscussionDanon disease in female patients is a challenging diagnosis that may not be identified until genetic testing has been performed.