bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tailoring rhodium-based metal-organic layers for parahydrogen-induced polarization: achieving 20% polarization of 1H in liquid phase
Authors: Chen Jiawei , Zhang Qi , Chen Tao , Zheng Zeyu , Song Yuhang , Liu Huichong , Chen Ziqiao , Wang Jing , Wang Haoshang , Sun Huijun , Wang Xinchang , Chen Zhong , Wang Cheng , Tian Zhongqun 
Published: November 2024

ABSTRACT
Heterogeneous catalysts for parahydrogen-induced polarization (HET-PHIP) would be useful for producing highly sensitive contrasting agents for magnetic resonance imaging (MRI) in the liquid phase, as they can be removed by simple filtration. Although homogeneous hydrogenation catalysts are highly efficient for PHIP, their sensitivity decreases when anchored on porous supports due to slow substrate diffusion to the active sites and rapid depolarization within the channels. To address this challenge, we explored 2D metal-organic layers (MOLs) as supports for active Rh complexes with diverse phosphine ligands and tunable hydrogenation activities, taking advantage of the accessible active sites and chemical adaptability of the MOLs. By adjusting the electronic properties of phosphines, TPP-MOL-Rh-dppb (TPP = tris(4-carboxylphenyl)phosphine), featuring a κ2-connected di(phosphine) ligand, generated hyperpolarized styrene achieving an over-2400-fold signal enhancement and a polarization level of 20% for 1H in methanol-d4 solution. The TPP-MOL-Rh-dppb effectively inherited the high efficiency and pairwise addition of its homogenous catalyst while maintaining the heterogeneity of MOLs. This work demonstrates the potential of 2D phosphine-functionalized MOLs as heterogeneous solid support for HET-PHIP.
Topological mechanical states in geometry-driven hyperuniform materials
Authors: Hong Sungyeon , Nerse Can , Oberst Sebastian , Saadatfar Mohammad 
Published: November 2024

Abstract
Disordered hyperuniform materials are increasingly drawing attention due to their unique physical properties, associated with global isotropy and locally broken orientational symmetry, that set them apart from traditional crystalline materials. Using a dynamic space-partitioning process, we generate disordered hyperuniform cellular structures where distinct patterns of pentagonal and heptagonal topological defects emerge within hexagonal domains. The microscopic defect dynamics are guided by local topological transitions, commonly observed in viscoelastic systems. This leads to a reduction in the system’s structural entropy as hyperuniformity is attained, marked by the rise and fall of certain locally favored motifs. Further, we introduce an elastic hyperuniform material that exhibits evolving topological mechanical states in the continuum. Through vibration experiments and numerical analysis, we show energy localization around these defects, which is tied to the topological band gaps inherent to our geometry-driven material. We suggest that this robust dynamic mechanism influences a broad spectrum of disordered systems, from synthetic materials to biological structures guided by stigmergic interactions.
Variation in evidence use across policy sectors: the case of Brazil
Authors: Saguin Kidjie , Guedes-Neto João V , Palotti Pedro Lucas Moura , Koga Natália Massaco , Carneiro Flavio Lyrio 
Published: November 2024

Abstract
Evidence use across policy sectors is widely believed to vary as each sector espouses a specific and dominant pattern in how it sources evidence. This view privileges the idea that a “culture of evidence” serves as a norm that guides behavior in the entire sector. In this article, we seek to nuance the policy sectoral approach to understanding evidence use by analyzing the results of a large-N survey of federal employees in Brazil (n = 2,177). Our findings show a diverse set of cultures of evidence with a few sectors like Science and Technology demonstrating a strong likelihood for using scientific evidence with most sectors showing a mixed pattern of sourcing evidence. However, a majority of the surveyed civil servants show an “indistinct” pattern of evidence use who are likely to not use any sources of evidence.
Supervisory cooperation and regulatory arbitrage
Authors: Beck Thorsten , Silva-Buston Consuelo , Wagner Wolf 
Published: November 2024

Abstract
While bank supervisors frequently cooperate across countries, novel data on 268 cooperation agreements reveal that such cooperation falls short of covering the global operations of large banking groups. We show that this causes material regulatory arbitrage: banking groups allocate lending activities and risk into third-country subsidiaries when cooperation agreements cover their operations in other countries. The average distortion in a country’s foreign lending caused by regulatory arbitrage is 21 percent, with the effect being magnified in the presence of a weak supervisory framework. Taken together, our results indicate that incompleteness in cooperation substantially diminishes its global effectiveness.
Environmental dependence of geometrical efficiency for the scintillation cell in radon and thoron measurement
Authors: Iwaoka Kazuki , Palad Lorna Jean H , Feliciano Chitho P , Tamakuma Yuki , Hosoda Masahiro , Tokonami Shinji , Kanda Reiko , Moritake Takashi 
Published: November 2024

Abstract
222Rn is recognized as a matter of international concern for human health risk. Because 220Rn as well as 222Rn coexist in the natural environment, thoron sometimes influences the experiment for radon measurement. It is important to measure radon and thoron separately to evaluate the risk of the exposure to 222Rn. As a discriminative measurement method for 222Rn and 220Rn, a simple technique with a single scintillation cell is well known. However, in recent years, the influence of atmospheric environment on the geometrical efficiency of the scintillation cell has not yet been investigated. In this study, environmental dependence of geometrical efficiency for the scintillation cell in 222Rn and 220Rn measurement was investigated using the Lucas type scintillation cell and Monte Carlo particle simulation. It was found that the influence of temperature and pressure on the geometrical efficiencies were larger than that of relative humidity.
The effects of antioxidant administration in the early stages of radiation-induced tumorigenesis
Authors: Yamauchi Kazumi , Tsutsumi Yuki , Kobayashi Toshiyuki , Komura Jun-ichiro 
Published: November 2024

Abstract
ApcMin/+ mouse was a model mouse for human familial adenomatous polyposis, and irradiation at an early age increases tumors in the small and large intestine. To study the effects of antioxidant administration on tumor incidence after continuous whole-body exposure to gamma rays, ApcMin/+ mice were exposed to a medium-dose-rate, 200 mGy/d, from postnatal Day 0 to 21 of age or a high-dose-rate of 0.65 Gy/min (total dose 4.2 Gy) on postnatal Day 7. The dams and pups were supplied with the N-acetylcysteine (NAC) in drinking water (7 g/L), from gestation Day 15 until weaning (21 days-old). A significant increase in the number of intestinal tumors were observed in ApcMin/+ mice irradiated with high dose-rate gamma rays as compared with the non-irradiated controls, but there was no significant difference in tumor counts between the non-irradiated controls and the medium-dose rate irradiation groups. NAC administration did not have any significant effect at least at this dose. These results suggest that the supplementation of anti-oxidant at the early stage of tumorigenesis does not suppress the formation of irradiation-induced small intestinal tumors.
Assessment of photon and proton-induced activation in particles accelerators
Authors: Nourreddine Abdel-Mjid , Collin Jonathan , Arbor Nicolas , Begin François , Barbagallo Massimo , Carminati Federico , Galli Carminati Giuliana , Horodynski Jean-Michel 
Published: November 2024

Abstract
Nuclear activation affects all operating, future, or dismantled particle accelerators used in various fields, from medical applications to industrial applications. This work is concerned with the study of the radioactivity induced in various materials (Sc, Cu, Tb, Ta, W, Au) irradiated by hard Bremsstrahlung photons from an electron beam and by secondary neutrons induced by a proton beam. In both cases, the primary beam features an 18 MeV kinetic energy. We have performed Monte Carlo simulations with MCNP, GEANT4, FLUKA, and PHITS, coupled with the analytical codes CINDER’90 or FISPACT-II, to estimate the threshold reaction rates and the induced radioactivity in the samples. We compared the simulations with experimental activation measurements performed by high-resolution gamma spectrometry at a decommissioned medical LINAC and around the CYRCé cyclotron. We also used CR-39 solid-state nuclear track detectors to characterize the thermal and fast neutron components of the secondary fields.
ESR measurement of carbonated hydroxyapatite for dosemeter
Authors: Seito Hajime , Yokozuka Eri , Oka Toshitaka , Kitatsuji Yoshihiro , Nagasawa Naotsugu 
Published: November 2024

Abstract
We have examined a dosimetry characteristic of carbonate hydroxyapatite (CO3HAp), which is a dental bone graft material. The purpose of this work is to investigate the reproducibility and stability of radiation-induced radicals on CO3HAp samples and assess the feasibility of using these materials as dosemeters. CO3HAp samples were exposed to gamma rays with dose range from 10 to 10 000 Gy. The electron spin resonance (ESR) spectra for irradiated samples were measured. Variation of peak-to-peak amplitude of the ESR signal intensity as a function of absorbed dose for CO3HAp was compared with that for alanine dosemeters, suggesting that the CO3HAp sample has a good linear dose response in the range from 10 to 10 000 Gy as well as does the alanine dosemeters.
Comparison of codes for calculation of projocted radiation-induced cancer risks
Authors: Kujiraoka Ikuo , Noguchi Yoshihiro , Shimada Kazumasa , Hirouchi Jun , Takahara Shogo 
Published: November 2024

Abstract
The lifetime attributable risk (LAR) of cancer caused by radiation exposure is crucial when deciding on radiological protection measures or protective actions for nuclear emergency preparedness and response. Although a model for estimating LAR among the Japanese population has been developed based on epidemiological data from A-bomb survivors, a flexible projection code implementing this model must be developed. This study investigated existing codes to contribute to the development of a projection code. Based on these investigations, we compared their LAR calculation results and explored the causes of their differences.
A diagnostic study on the application of segmental somatosensory evoked potential examination to acquired premature ejaculation
Authors: Zhao Yin , Chen Minhui , Li Jiacheng , Li Zheyang , Xu Zilei , Liao Zedong , Xu Keli , Huang Xiaojun 
Published: November 2024

Abstract

Background
Premature ejaculation (PE), affecting approximate 5%, has an unclear pathogenesis, limited treatment efficacy, and a lack of effective diagnostic methods.

Aim
This prospective diagnostic study aimed to compare segmental dorsal penile nerve somatosensory evoked potentials (DNSEP) differences among patients with acquired premature ejaculation (APE), primary premature ejaculation (PPE), and healthy controls.

Method
This prospective diagnostic study examined patients suffering from PE who visited the outpatient clinic of the Department of Urology of the Second Affiliated Hospital of Zhejiang University School of Medicine from January 1, 2022 to February 28, 2023. According to the definition of PE by the ISSM, 16 cases comprised the healthy control group, 31 in the APE group, and 28 in the PPE group. Each group was examined based on the segmental DNSEP with electrodes recording at multiple locations (the selected location was at the Cz and the C7). The latency time of the evoked potential obtained at Cz was P40, and that obtained at C7 was P30. The P30/P40 ratios of P40, P30, and DNSEP wave amplitudes at C7 and Cz were compared among the 3 groups of patients.

Result
No group differences were found in P40 latency at Cz. However, PPE showed higher DNSEP amplitude at Cz, while APE showed lower amplitudes compared with controls. Both APE and PPE had significantly shorter P30 latency at C7 than controls. SEP amplitude at C7 was similar in APE and PPE but lower than in controls. The P30/P40 ratio was lower in APE compared with PPE and controls.

Clinical implications
Segmental SEP may offer more assistance in localizing neurological lesions, potentially guiding clinical treatment.

Strengths and limitations
In this study, the innovative use of the P30/P40 ratio was proposed, maintaining consistency in emotional states and measurement conditions for the same patient. However, limitations include a restricted number of patient cases and challenges in obtaining a diverse control group, potentially introducing bias. In addition, not considering subclinical premature ejaculation and the comorbidity of PE + ED (LCEE) in patient stratification is another limitation of this study. Results suggest a correlation between secondary PE and underlying conditions, such as obesity and lumbar spine injuries. The study validates multi-site somatosensory-evoked potential examination for locating neural lesions but acknowledges the need for future invasive needle electrode AEP testing to analyze neuropathological changes more comprehensively.

Conclusion
In conclusion, segmental DNSEP examination aids in localizing neuropathy in APE patients, and the P30/P40 ratio proves more accurate in diagnosing APE than P40 alone.
Nine in one: integrative taxonomic evidence of hidden species diversity in the widespread Zambezi grunter, Parauchenoglanis ngamensis (Siluriformes: Auchenoglanididae), from southern and south-central Africa
Authors: Sithole Yonela , Vreven Emmanuel J W M N , Bragança Pedro H N , Musschoot Tobias , Chakona Albert 
Published: November 2024

Abstract
The Zambezi grunter, Parauchenoglanis ngamensis, is currently distributed across four (sub)basins in southern and south-central Africa, namely the Okavango, upper Zambezi, Kwanza, and Kasai. The present study used a combination of molecular (barcoding), colour pattern, and other morphological data to explore the possible existence of hidden species diversity within this species. Based on the available samples, analyses of molecular data uncovered seven well-supported (.96–1.00 Bayesian posterior probabilities) candidate species, with 1.6%−8.5% genetic divergence between them. These, in addition to two more candidate species without genetic data, exhibited a combination of consistent colour pattern and other morphological differences that supported their distinction. The present study redescribes P. ngamensis, which is confined to the Okavango and upper Zambezi (sub)basins, and describes eight new species: two from the Kwanza Basin and six from the Kasai sub-basin. The fact that some of the species occur allopatrically, whereas others are sympatric and even syntopic indicates the complex palaeogeographical history of these basins. In addition, the high species diversity discovered in the Kasai sub-basin seems to be related to its highly peculiar hydrography. Accurate delimitation of species boundaries and mapping of their distribution is crucial for conservation assessments and guiding their protection.
“I Was Broken and Still Had to Stay Strong. I Cannot Be Weak”
Authors: Reimer Alinda , Hoffmann Jan , Mause Laura , Heinen Carolin , Dresbach Till , Scholten Nadine 
Published: November 2024

Background:
The challenging transition to parenthood affects both mothers and fathers; yet, the strain intensifies with a premature birth in the neonatal intensive care unit (NICU), underscoring the importance of acknowledging and addressing potential differences in parental roles.

Purpose:
This paper aimed to investigate how parental role conflicts among mothers and fathers of preterm-born infants hospitalized in German NICUs manifest and investigated potential parental resources.

Methods:
Twenty-four participants, 17 mothers, and seven fathers of very low birth-weight infants were interviewed. A thematic content analysis was performed at a semantic level.

Results:
Fathers feel pressured to fulfill the role expectations, often leading to the suppression of paternal feelings and needs. For mothers, deviating from societal expectations regarding their expressive roles can be distressing, as they worry that such deviation might hinder their infants from having a successful start in life. Consulting with healthcare professionals shows to ease challenges for both parental roles.

Implications for Practice and Research:
Maternal and paternal challenges are often rooted in expectations placed on their societal roles. Highlighting these challenges can be essential for increasing awareness and effectively addressing them. Tailored nursing practices may have the potential to facilitate individuals’ navigation of uncertainties and fulfillment of caregiving roles.
The Significance of rS Change in the V2 Lead for Diagnosing Ventricular Tachycardia Deserves Attention: A Case Report
Authors: Li Jian , Li Shixing , Zhang Chuang , Shi Xiangmin 
Published: November 2024

Abstract
Occasionally, incessant ventricular tachycardia (VT) exhibits a narrow QRS complex pattern that could be misdiagnosed as supraventricular tachycardia. In this case, a 66-year-old woman was referred to the emergency department due to the worsen hemodynamic and incessant VT manifesting as a narrow QRS complex pattern that was initially misdiagnosed as supraventricular tachycardia (SVT), which was unresponsive to antiarrhythmic drugs. The electrocardiogram manifestation of VT was characterized by an rS configuration in lead V2 with Rs pattern in leads V1 and V3, and the R-wave amplitude of lead V1 and V3 was greater than that of lead V2, which was different from the typical electrocardiogram features of right bundle branch block. The patient was subsequently found to have suspected acute myocarditis when the cause of the disease was investigated. A combination of high-dose methylprednisolone, immunoglobulin and intra-aortic balloon pump was given immediately. Hemodynamics gradually stabilized, and ventricular tachycardia did not recur. The rS change in the V2 lead may be helpful to distinguish VT from supraventricular tachycardia.
Immune checkpoint inhibitor therapy as a neoadjuvant treatment for muscle-invasive bladder carcinoma: A narrative review
Authors: Ding Sentai , Wu Chenrui , Cao Jishuang , Lyu Jiaju 
Published: November 2024

Abstract
Immunotherapy has become a standard treatment for patients with advanced urothelial carcinoma, and neoadjuvant immunotherapy is currently being extensively explored. This review highlights the initial findings and key clinical therapeutic insights on immune checkpoint inhibitors in the early treatment of muscle-invasive bladder cancer across diverse patient populations. Most available literature consists of clinical investigations involving small sample, single-arm phase II trials, with the primary endpoint being the pathologic complete response rate. Early results of immune checkpoint inhibitors in the neoadjuvant treatment of bladder cancer have demonstrated promising efficacy. However, these findings require confirmation in large phase III clinical trials, with particular emphasis on long-term survival benefits and identifying patients who respond to treatment.
Case reports of type 1 cystic biliary atresia—A rare variant of biliary atresia along with review of literature
Authors: Gupta Rahul , Vijay Priti , Gupta Atul 
Published: November 2024

Abstract
Cystic biliary atresia is a rare (5%–10%) variant of type 1 biliary atresia. The present report intends to share our experience with cystic variant of biliary atresia along with a review of pertinent literature. The first case was a 3-month-old infant with cholestatic jaundice with preoperative diagnosis of an infantile type of choledochal cyst. The second case was a 4-month-old twin infant with cholestatic jaundice and with preoperative differential diagnosis of either cystic biliary atresia or an infantile type of choledochal cyst (cyst located within the hepatic hilum). Cystic biliary atresia was confirmed intraoperatively in both the patients. In the first infant, Kasai portoenterostomy procedure was performed, whereas in the second patient, the hepaticoduodenostomy procedure was performed. At 6 months’ follow-up, there was no episode of cholangitis in the first and two episodes in the second case. In both patients, total bilirubin was trending down on follow-up. Cystic biliary atresia presents with cystic dilatation of proximal biliary tract. Type 1 cystic biliary atresia may masquerade as infantile variant of choledochal cyst. The Kasai portoenterostomy procedure is a standard palliative surgical procedure for patients with biliary atresia to restore bile drainage. A high index of suspicion with early operative intervention is recommended to palliate cholestasis in the infant with cystic variant of biliary atresia.
HNF4α-CDKL3 axis restricts MASLD progression by targeting FoxO1 via non-canonical phosphorylation
Authors: Pang Zhongqiu , Zhang Hui , Zheng Shaoqin , Yang Xueling , Liu Chang , Han Qing , Chen Yi , Li Zexu , Zhang Xi , Cao Liu , Wang Qiang , Cao Yanli , Sun Xun , Zhao Pu , Li Xuexin , Zheng Qianqian , Sheng Ren 
Published: November 2024

Background and Aims:
Metabolic dysfunction-associated steatotic liver disease (MASLD) is a worldwide disease with a broad spectrum of symptoms. Though being mild at early stages, further development of MASLD causes steatohepatitis, cirrhosis, liver cancers and accompanied diabetes. Discovery of the critical regulators in MASLD progression hold great values in both basic and translational medicine.

Approach and Results:
Herein, we identified Cyclin-dependent kinase like 3 (CDKL3) as a primary guardian against MASLD progression. Mice with liver-specific Cdkl3 ablation developed severe MASLD-related hepatic inflammation, fibrosis and diabetes. Mechanism-wise, CDKL3 directly phosphorylates FoxO1 on an unconventional site for the ubiquitination-dependent degradation of FoxO1, thereby remarkably alleviating glycogen and lipid accumulation and essentially preventing the onset of higher MASLD stages. Moreover, hepatic CDKL3 is a direct target gene of HNF4α. HNF4α is inhibited during MASLD, which led to diminished CDKL3 expression. The CDKL3-mediated crosstalk of HNF4α and FoxO1 hence forms a feedback loop in MASLD progression.

Conclusions:
We unearthed an alternative but critical regulatory path of FoxO1 by HNF4α-CDKL3 axis. CDKL3 serves as a guardian against MASLD and also may function as a prognosis indicator of FoxO1 inhibitor in MASLD treatment.