bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Role of Ejection Fraction to Clinical Outcome of Acute Ischemic Stroke Patients
Authors: Rahmayani Fidha , Setyopranoto Ismail ,   Paryono
Published: April 2018

ABSTRACT
Aims: The aim of the study was to determine the effect of left ventricular ejection fraction on clinical outcomes of acute ischemic stroke patients. Study Design: This study design was a prospective cohort observational study. Place and Duration of Study: This study was conducted at Stroke Unit, Neurology Ward, and Cardiology Ward at the Dr. Sardjito Hospital, Yogyakarta, Indonesia, between July and December 2016. Materials and Methods: Hospitalized acute ischemic stroke patients were recruited, with sample was taken by consecutive sampling until reaching amount fulfilling inclusion criterion was 62 persons. In this study, clinical outcomes were measured by National Institutes of Health Stroke Scale (NIHSS) scores as well as dependent variables and left ventricular ejection fraction as independent variables. Logistic regression analyses were performed to discover any potential independent variable that can influence the left ventricular ejection fraction role at the clinical outcomes with NIHSS scores. Results: Multivariate analyses revealed that several variables were significantly interacted with the influence of left ventricular ejection fraction at the clinical outcomes with NIHSS scores. These variables were the left ventricular ejection fraction <48% (95% confidence interval [CI]: 0.691–0.925; P = 0.001), left ventricular ejection fraction + low high-density lipoprotein (HDL) (95% CI: 0.73–0.949; P = 0,001), left ventricular ejection fraction + diabetes mellitus (DM) (95% CI: 0.799–0.962; P = 0,001), and left ventricular ejection fraction + low HDL + DM (95% CI: 0.841–0.98; P = 0,001). Conclusion: The influence of the lower left ventricular ejection fraction to clinical outcome of ischemic stroke patients has a worsening of neurological deficit outcome by considering the combination of several independent variables including the DM and low HDL.
Bedside Ultrasonography as an Alternative to Computed Tomography Scan for the Measurement of Optic Nerve Sheath Diameter
Authors: Yanamandra Uday , Gupta Amul , Yanamandra Sushma , Das Subrat Kumar , Patyal Sagarika , Nair Velu 
Published: April 2018

ABSTRACT
Background: Optic nerve sheath diameter (ONSD) as measured by optic nerve sheath ultrasonography (ONSU) is used as a surrogate marker of intracranial pressure (ICP), especially in resource-limited settings. There is a growing interest in the use of ONSU in emergency and high-altitude setups. Notwithstanding multiple studies done on this subject, there is a paucity of data regarding standardization of techniques and comparison of ONSU with computed tomography (CT). Materials and Methods: Thirty-five patients with a diagnosis of high-altitude cerebral edema were enrolled in the study. ONSD was measured in all patients using ONSU, along visual and coronal axis, and CT scan. We repeated ONSU in these patients on days 3, 7, 10, and 15 (day of discharge). Correlation between visual and coronal axis as well as CT scan was analyzed. Results: The correlation of visual to coronal and coronal to visual was equally significant (both correlation coefficients being R
2 = 0.983). Correlation of ONSD by visual axis to CT scan was better than coronal axis (correlation coefficient R
2 = 0.986 vs. 0.96, respectively). Conclusion: In our study, we found a strong correlation between the visual and coronal axes. Thus, either of the two axes can be used for monitoring ICP. However, it has been found that measurements along the coronal axis are challenging, especially in the emergency setup. ONSD measured along visual axis correlated better with CT scan as compared to the coronal axis.
Obsessive-Compulsive Inventory-Revised: Factor Structure, Reliability, Validity, and Suicide Risk Screening Characteristics among Nigerian Patients with Schizophrenia
Authors: Opakunle Tolulope , Aloba Olutayo , Akinsulore Adesanmi , Opakunle Olubukola , Fatoye Femi 
Published: April 2018

ABSTRACTObjective: This study attempted to explore the feasibility of use of the 18-item Obsessive-Compulsive Inventory-Revised (OCI-R) as a subjective suicide risk assessment tool in a cross-sectional sample of Nigerian patients with schizophrenia. Materials and Methods: Two hundred and thirty-two outpatients with schizophrenia were recruited from the mental health clinic of a university teaching hospital in Southwestern Nigeria. They completed the OCI-R in addition to the Social and Occupational Functioning Assessment Scale, the Positive and Negative Syndrome Scale, and a sociodemographic and illness-related questionnaire. The patients were objectively interviewed with the Mini-International Neuropsychiatric Interview suicidality module items to assess their suicide risk. Results: The 18-item OCI-R demonstrated satisfactory sensitivity (0.900) and specificity (0.662) at a total cutoff score of 10 in relation to the identification of Nigerian patients with schizophrenia with significant suicide risk. At this cutoff score, the area under the receiver operating characteristic curve was 0.817 (95% confidence interval: 0.735–0.898), and positive predictive value (0.726) and negative predictive value (0.869) were also satisfactory. The OCI-R also demonstrated satisfactory internal consistency and construct validity. Conclusion: The OCI-R has demonstrated to be useful as a subjective suicide risk assessment tool among Nigerian schizophrenia patients.
Practical consensus recommendatons for Paget’s disease in breast cancer
Authors: Gaurav A. , Gupta V. , Koul R. , Dabas S. , Sareen R. , Geeta K. , Arora V. , Parikh Purvish M. , Aggarwal S. 
Published: April 2018

AbstractPaget's disease of the breast is a rare type of cancer of the nipple–areola complex and that is often associated with an underlying in situ or invasive carcinoma. Diagnosis and treatment of Paget's disease is controversial. Expert oncologists discuss on the update on the approaches of Paget's disease diagnosis and its treatment options. This expert group used data from published literature, practical experience and opinion of a large group of academic oncologists to arrive at this practical consensus recommendations for the benefit of community oncologists.
Practical consensus recommendations for gestational breast cancer
Authors: Sekhon J. S. , Naik N. , Bansal P. , Bansal I. , Dhull A. , Goel A. , Ramachandran C. S. , Shinde S. , Aggarwal S. , Parikh P. M. 
Published: April 2018

AbstractThis manuscript provides a practical and easy to use consensus recommendation to community oncologists on how to manage gestational breast cancer.
Practical consensus recommendations regarding the use of hormonal therapy in metastatic breast cancer
Authors: Rajappa Senthil , Bajpai J. , Basade M. , Ganvir M. , Goswami C. , Murali A. , Rathi A. K. , Kaushal V. , Jain S. , Parikh Purvish M. , Aggarwal S. 
Published: April 2018

AbstractMetastatic breast cancer (MBC) is cancer that has spread from the breast to another part of the body or has come back in another distant location. Treatment options for MBC depend on several factors. One of these factors is the levels of hormone receptors (HRs) in the tumor. Cancers with high levels of HRs, called HR-positive, use the hormones estrogen and progesterone to grow and spread. Hormonal therapy is a type of treatment specifically for HR-positive breast cancer. This expert group used data from published literature, practical experience and opinion of a large group of academic oncologists to arrive at these practical consensus recommendations in regards with the use of hormonal therapy and the management of HR-positive MBC for the benefit of community oncologists.
Survey of the Protection Mechanisms to the SSL-based Session Hijacking Attacks
Authors: Hossain Md. Shohrab , Paul Arnob , Islam Md. Hasanul , Atiquzzaman Mohammed 
Published: April 2018

Web communications between the server and the client are being used extensively. However, session hijacking has become a critical problem for most of the client-server communications. Among different session hijacking attacks, SSL stripping is the most dangerous attack. There are a number of measures proposed to prevent SSL tripping-based session hijacking attacks. However, existing surveys did not summarize all the preventive measures in a comprehensive manner (without much illustration and categorization). The objective of this paper is to provide a comprehensive survey of existing measures against SSL stripping-based session hijacking attacks and compare those measures. In this paper, we have classified all the existing preventive measures for SSL stripping-based session hijacking attacks into two main categories: client-side measures and serverside measures. We have illustrated the proposed solutions comprehensively with useful diagrams for clarification. We have also compared them based on different performance criteria. This paper will help web security researchers to have a comparative analysis of all solutions for the SSL stripping based attacks, thereby improving existing solutions to better protect the users from session hijacking attacks.
The relationship between left ventricular diastolic function and the autonomic nervous function in elderly patients with mild-to-moderate essential hypertension
Authors: Liu Qunwei , Lin Xin , Dong Lei , Han Limin , Chang Feng 
Published: April 2018

Objective: To investigate the relationship between left ventricular diastolic function (LVDF) and autonomic nervous function in elderly patients with mild-to-moderate essential hypertension.Design: A total of 146 elderly patients with mild-to-moderate essential hypertension were enrolled in our hospital from January, 2015 to October, 2017. Blood pressure was recorded, and biochemical indexes and the N-terminal pro-brain natriuretic preptide (NT-proBNP) were investigated. 2-dimensional echocadiolography was used to measure the parameters of LVDF. Based on the classification standard of LVDF, all subjects were divided into two groups: normal LVDF group (n = 72), left ventricular diastolic dysfunction group (n = 74). At the same time, the dynamic electrocardiogram were investigated for all subjects to monitor the indexes of time on heart rate variability (HRV).Results: (1) The level of NT-proBNP, left ventricular mass index (LVMI), interventricular septal thickness (IVST) and LVPWT increased significantly (p < .05 for all), while the level of PNN50, rMSSD, SDANN and SDNN decreased significantly (p < .05 for all) in left ventricular diastolic dysfunction group (abnormal LVDF group) compared with that in normal LVDF group (normal LVDF group); (2) The partial correlation analysis showed that rMSSD, PNN50 and triangle index were negatively correlated with peak A (r = -0.208, -0.219, -0.211, p < .05 for all), and positive correlated with the ratio of peak E to peak A (E/A) (r = 0.179, 0.184, 0.181, p < .05); SDNN were negatively correlated with NT-proBNP and E/E’ (r = -0.183, -0.181, p < .05 for all), positive correlated with E’ (r = 0.178, p < .05); (3) Multiple stepwise regression analysis showed that peak A and E/A were independent influencing factors for PNN50 (β = -0.261, p = .004; β = 0.179, p = .016); E/E’ and NT-proBNP were independent influencing factor for SDNN (β = -0.163, p = .018; β = -0.172, p = .022).Conclusions: Left ventricular diastolic dysfunction is closely related to impaired autonomic nervous function in elderly patients with mild-to-moderate essential hypertension.
L’enseignement et l’action créative : de l’inférence comme indice de professionnalisation du futur enseignant de musique
Authors: Balmori Isabel 
Published: April 2018

« Comment la société organise-t-elle des expertises ? » À partir de la question formulée par le sociologue américain Abbott (1988) et dans le cadre d’une recherche menée par l’équipe DAM de l’Université de Genève, nous nous sommes penchés sur les pratiques des formateurs et des étudiants en chant — le premier assumant institutionnellement un rôle d’experts. Nous avons analysé ces pratiques sur la base des trois opérations caractéristiques du professionnel : le diagnostic, l’inférence et le traitement, théorisés par Abbott. Leur mise en parallèle avec les pratiques de transmission depuis le XVIIe siècle jusqu’à nos jours nous a permis de mettre en relief de profondes transformations dans l’enseignement du chant dit « classique », notamment dans l’étape d’inférence. Cette étape permettrait au professeur de chant expérimenté de déployer sa créativité, mais constituerait aussi un vrai défi pour l’étudiant en voie de professionnalisation.
La collaboration au coeur d’une évaluation de dispositif de formation. Le cas d’une recherche-intervention multipartenariale
Authors: AUSSEL Lucie 
Published: April 2018

Cette contribution s’inscrit dans le contexte d’un laboratoire commun (LabCom) porté par une équipe de recherche en sciences humaines et sociales (SHS) et un acteur socio-économique de la région toulousaine. L’objectif de ce partenariat était de « faire en sorte que le monde de la recherche académique se rapproche des entreprises » (convention). Ainsi, ce LabCom a permis la collaboration d’une petite et moyenne entreprise, organisatrice de congrès et d’une équipe de recherche pluridisciplinaire en SHS. Nous nous intéressons dans le cadre de ce dossier thématique à l’évaluation de dispositif lorsque qu’elle se développe en contexte de recherche collaborative. Ainsi, une partie des résultats de l’évaluation d’un dispositif expérimental de formation, développé au sein de ce congrès de cardiologie interventionnelle, sera présentée.
Empirical evaluation of data normalization methods for molecular classification
Authors: Huang Huei-Chung , Qin Li-Xuan 
Published: April 2018

BackgroundData artifacts due to variations in experimental handling are ubiquitous in microarray studies, and they can lead to biased and irreproducible findings. A popular approach to correct for such artifacts is through post hoc data adjustment such as data normalization. Statistical methods for data normalization have been developed and evaluated primarily for the discovery of individual molecular biomarkers. Their performance has rarely been studied for the development of multi-marker molecular classifiers—an increasingly important application of microarrays in the era of personalized medicine.MethodsIn this study, we set out to evaluate the performance of three commonly used methods for data normalization in the context of molecular classification, using extensive simulations based on re-sampling from a unique pair of microRNA microarray datasets for the same set of samples. The data and code for our simulations are freely available as R packages at GitHub.ResultsIn the presence of confounding handling effects, all three normalization methods tended to improve the accuracy of the classifier when evaluated in an independent test data. The level of improvement and the relative performance among the normalization methods depended on the relative level of molecular signal, the distributional pattern of handling effects (e.g., location shift vs scale change), and the statistical method used for building the classifier. In addition, cross-validation was associated with biased estimation of classification accuracy in the over-optimistic direction for all three normalization methods.ConclusionNormalization may improve the accuracy of molecular classification for data with confounding handling effects; however, it cannot circumvent the over-optimistic findings associated with cross-validation for assessing classification accuracy.
Acid‐Responsive Polymer Additives Increase RNA Transfection from Lipid Nanoparticles
Authors: Cheung Timothy H. , Fuchs Alexander , Shoichet Molly S. 
Published: October 2024

AbstractLipid nanoparticles (LNPs) are the most clinically advanced RNA delivery technology, but their efficiency is limited by low RNA release after endosome disruption. To improve RNA release, an acid‐responsive polymer is synthesized with which to formulate LNPs for RNA encapsulation and release. Specifically, three acid‐responsive poly(lactic acid)‐block‐poly(carboxybetaine) zwitterionic derivatives are designed and synthesized that are cationic and complexed with RNA at pH 7.4, but are neutral following cleavage at endosomal pH, thereby having lower affinity to RNA. The polymers are formulated into each of the clinically approved Onpattro, Moderna, or Pfizer LNP formulations to produce hybrid polymer‐lipid nanoparticles (PLNPs). With the PLNPs, the IC50 values of multiple small interfering RNAs (siRNAs) decreased up to 5.4‐fold compared to parent LNPs in several cell lines. Moreover, messenger RNA (mRNA) transfection increased up to two fold. The acid‐responsive polymers in PLNPs accounted for the enhanced RNA transfection as this phenomenon is lost with acid‐inert polymers. Confocal microscopy confirmed that cytosolic RNA concentration increased using the acid‐responsive polymers; conversely, uptake and endosomal escape are identical to existing LNPs. This confirmed that enhanced RNA transfection is due to increased RNA dissociation from its carrier. The novel polymer represents a versatile strategy to increase RNA transfection from LNPs.
Upcycling Industrial Biomass Wastes Into Aerogels Using Zinc Chloride Salt Hydrates
Authors: Zhang Mairui , Liao Yang , Han Nara , Lee Seoku , Leem Gyu , Kim Kwang Ho , Pan Xuejun , Wie Jeong Jae , Yoo Chang Geun 
Published: October 2024

AbstractEnd‐of‐life paper products, including food packages and rejected fibers from the paper industry, are unrecyclable biomass wastes and thus generally landfilled or incinerated. One of the major obstacles to their recycling is the existence of impurities besides cellulose fiber in the biomass wastes. In this study, a fabrication method is investigated to upcycle biomass wastes directly into high‐performance aerogels without separation of impurities. Surprisingly, this study observes that residual impurities participate in cross‐linking reactions for the aerogel formation. In this study, zinc chloride salt hydrate is applied to convert biomass wastes to aerogel via a dissolution‐regeneration process. The fabricated aerogels exhibited high water absorption capacity (15 times its weight), as well as comparable mechanical strength and thermal insulation performance to the reported cellulose aerogels. In addition, the impurities (i.e., calcium‐based inorganic salt) assisted in the cross‐linking of the cellulose network for the aerogel formation. The scanning electron microscopy (SEM) image of the aerogel generated from the rejected fibers showed a honeycomb inner structure. The rejected fiber aerogels also demonstrated a high compressive modulus of 51 MPa and a low thermal conductivity of 0.029 W m−1 K−1. The results for water absorption and thermal insulation suggest excellent potential across various application domains.
Economic considerations of in‐season potassium applications to soybean using payoff matrices
Authors: Ortel C. C. , Roberts T. L. , Popp M. , Ross W. J. , Slaton N. A. , Parvej M. R. 
Published: October 2024

AbstractPotassium (K) deficiency is a common yield‐limiting factor in Arkansas soybean (Glycine max (L.) Merr.) production that can be addressed with innovative supplemental fertilizer application. An established leaf sampling protocol and dynamic critical concentration allow accurate diagnosis of K deficiency with corresponding recommendations for corrective, in‐season K fertilizer applications at site‐specific rates and times to reach anticipated yield goals. However, the profitability of in‐season K fertilizer applications to irrigated soybean remains unclear. Research was conducted in Arkansas from 2021 to 2023 to evaluate multiple rates of in‐season applications of muriate of potash to soybean at 15 and 30 days after first flower (DAR1). The economic ramifications of in‐season fertilizer applications were quantified by calculating yield averages, partial returns (PRs), and regret when comparing PR to not fertilizing, each assuming 5‐year average prices for fertilizer and soybean grain. Significant yield responses to in‐season potash fertilizer were found at both 15 and 30 DAR1 times. These yield increases translated to large increases in PR or lower regret when compared to using no fertilizer. Corrective applications of 74–112 kg K ha−1 were often considered optimal, with risk assessments provided to allow informed decisions. Results were summarized by category of leaf‐K concentration, and treatment averages were provided to calculate payoff matrices for 15 and 30 DAR1 times. The resulting payoff matrices can be used as a decision support tool with any grain and fertilizer price to facilitate informed management decisions that optimize profitability as soybean and fertilizer prices impact optimal outcomes.
Targeted microwave ablation of localised prostate cancer: Initial results of VIOLETTE trial
Authors: Delongchamps Nicolas Barry , Peltier Alexandre , Potiron Eric , Bladou Franck , Anract Julien , Diamand Romain , Robert Grégoire , Messas Aurel , Van Velthoven Roland 
Published: October 2024

AbstractObjectiveThe aim of this study was to assess the precision and safety of targeted microwave ablation (TMA) using organ‐based tracking (OBT) fusion, in patients with intermediate risk prostate cancer.Patients and methodWe conducted a prospective, multicentric trial. Eligible patients had a prostate‐specific antigen (PSA) < 20 ng/mL, a magnetic resonance imaging (MRI)‐visible index tumour of Gleason score 3 + 4, with largest axis ≤15 mm and distant of at least 5 mm from the rectum and apex. TMA was performed with microwave needle applicator using OBT fusion, with a transperineal or a transrectal approach. In this interim analysis, we evaluated precision, safety, urinary and sexual outcomes, and PSA density kinetics.ResultsAt this point, 37 patients were treated in five centres. Median (interquartile range) age is 68 (63–72) years. Baseline median prostate volume and PSA are of 45 (34–57) mL and 8 (6.2–10.8) ng/mL, respectively. Median largest tumour axis on T2W MRI is of 11 mm (10–13). Patients were treated under general anaesthesia or conscious IV sedation in an outpatient setting. Anaesthesia had a median duration of 78 (66–90) min. A median number of 3 (2–4) 12‐W ablations of 2 to 5 min were performed per patient. After a median follow‐up of 6 (2.4–10) months, we observed 58 adverse events (AE) in 22 patients. These were of Common Terminology Criteria for Adverse Events (CTCAE) grade 1, 2 and 3 in 43 (74%), 13 (22%) and 2 (4%) cases. Six (15%) patients had an acute urinary retention, five of which considered as severe AE because of rehospitalisation. We did not observe any significant difference in International Prostate Symptom Score (IPSS), Male Sexual Health Questionnaire‐ejaculatory dysfunction (MSHQ‐EjD) and International Index of Erectile Function (IIEF5) from baseline to last follow‐up. Median PSA density evolved from 0.2 (0.1–0.3) at baseline to 0.1 (0.07–0.16) at 12 months.ConclusionsThese preliminary results suggest that TMA using OBT fusion is precise and safe in patients with intermediate risk localised prostate cancer. Further inclusions and follow‐up are needed to assess oncological outcome.