bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effectiveness of Two Wavelengths of Diode Laser and Amorphous Calcium Phosphate–Casein Phosphopeptide Mousse in the Treatment of Dentinal Hypersensitivity: A Randomized Clinical Study
Authors: Nambiar Manjusha , Shetty Bhavya , Fazal Ibrahim , Khan Safiya Fatima , Shah Mehul A. , Kamath Vignesh , Faruk Shahaziya , Jalaj Vaishnavi , N. Sowmya 
Published: November 2024

Objective: In office methods for immediate relief of dentinal hypersensitivity (DH) has long been an area of research. This study compared the efficacy of 660 nm diode laser, 980 nm diode laser, and amorphous calcium phosphate–casein phosphopeptide (ACP–CPP) agent in the treatment of DH.Materials and Methods: A total of 39 patients with minimum three hypersensitive teeth in at least one quadrant were selected and randomly divided into three groups; Group A, B, and C patients were treated by 660 nm diode laser, 980 nm diode laser, and ACP–CPP agent, respectively. All the hypersensitive teeth were stimulated with tactile; thermal and air stimuli, and the pretreatment and posttreatment hypersensitivity scores were evaluated with the numeric rating scale (NRS) at baseline, 30 min, 1 week, 1 month, 3 months, and 6 months. The Shapiro–Wilk test was used to determine the uniformity of the data. The Chi‐square (χ2) test of significance was used to compare proportions. For intergroup comparison, the Kruskal–Wallis test and the Mann–Whitney U test were utilized.Results: At 30 min and 1 week, the 980 nm laser was more effective than the 660 nm laser, but there was no statistically significant difference between the two groups at 1, 3, and 6 months. Throughout the trial period, the 660 nm and 980 nm diode lasers were more effective than the ACP–CPP agent in lowering DH.Conclusions: 660 nm diode laser, 980 nm diode laser, and ACP–CPP agent showed positive prospective as effective desensitizers when utilized as a clinical procedure.
Phase Ib Pharmacodynamic Study of the MNK Inhibitor Tomivosertib (eFT508) Combined With Paclitaxel in Patients With Refractory Metastatic Breast Cancer
Authors: Ferrario Cristiano , Mackey John , Gelmon Karen A. , Levasseur Nathalie , Sorensen Poul H. , Oo Htoo Zarni , Negri Gian L. , Tse Veronica W.L. , Spencer Sandra E. , Cheng Grace , Morin Gregg B. , del Rincon Sonia , Cotechini Tiziana , Gonçalves Christophe , Hindmarch Charles C.T. , Miller Wilson H. , Amiri Mehdi , Basiri Tayebeh , Villareal-Corpuz Victor , Sperry Sam , Gregorczyk Kevin , Spera Gonzalo , Sonenberg Nahum , Pollak Michael 
Published: November 2024

Abstract

Purpose:
Preclinical data motivate clinical evaluation of inhibitors of MAPK-interacting kinases 1 and 2 (MNK1/2). We conducted a phase 1b clinical trial to study target engagement and safety of tomivosertib, a MNK1/2 inhibitor, alone and in combination with paclitaxel.

Patients and Methods:
Eligible patients had metastatic breast cancer resistant to standard-of-care treatments. Biopsies were obtained at baseline and during treatment with tomivosertib, and then tomivosertib was continued with the addition of paclitaxel until disease progression or toxicity. Serum drug levels were measured, and pharmacodynamic endpoints included IHC, proteomics, translatomics, and imaging mass cytometry.

Results:
Tomivosertib alone and in combination with paclitaxel was well tolerated. There was no pharmacokinetic interaction between the drugs. We observed a clear reduction in phosphorylation of eIF4E at S209, a major substrate of MNK1/2, and identified tomivosertib-induced perturbations in the proteome, translatome, and cellular populations of biopsied metastatic breast cancer tissue.

Conclusions:
We conclude that tomivosertib effectively inhibits MNK1/2 activity in metastatic breast cancer tissue and that it can safely be combined with paclitaxel in future phase II studies. We demonstrate feasibility of using proteomic profiles, translatomic profiles, and spatial distribution of immune cell infiltrates for clinical pharmacodynamic studies.
Calculating Future 10-Year Breast Cancer Risks in Risk-Adapted Surveillance: A Method Comparison and Application in Clinical Practice
Authors: Zachariae Silke , Quante Anne S. , Kiechle Marion , Rhiem Kerstin , Fehm Tanja N. , Schröder Jörg-Gunther , Horvath Judit , Leinert Elena , Dikow Nicola , Ronez Joelle , Schönfeld Mirjam , van Mackelenbergh Marion T. , Schatz Ulrich A. , Meisel Cornelia , Aktas Bahriye , Witt Dennis , Mehraein Yasmin , Weber Bernhard H.F. , Solbach Christine , Speiser Dorothee , Hoyer Juliane , Faigle-Krehl Gesine , Much Christiane D. , Müller-Rausch Alma-Verena , Villavicencio-Lorini Pablo , Banys-Paluchowski Maggie , Pieh Daniel , Schmutzler Rita K. , Fischer Christine , Engel Christoph 
Published: November 2024

Abstract
The German Consortium for Hereditary Breast and Ovarian Cancer (GC-HBOC) has successfully implemented risk-adapted breast cancer surveillance for women at high breast cancer risk in Germany. Women with a family history of breast and ovarian cancer but without pathogenic germline variants in recognized breast cancer risk genes are recommended annual breast imaging if their predicted 10-year breast cancer risk is 5% or higher, using the Breast and Ovarian Analysis of Disease Incidence and Carrier Estimation Algorithm (BOADICEA) breast cancer risk model, as outlined in the current GC-HBOC guideline. However, women who initially do not meet this risk threshold may do so later, even if there is no new cancer in their family. To determine when this threshold is crossed, one could annually repeat BOADICEA calculations using an aging pedigree: the “prediction by aging pedigree” (AP) approach. Alternatively, we propose a simplified and more practical “'conditional probability” (CP) approach, which calculates future risks based on the initial BOADICEA assessment. Using data from 6,661 women registered with GC-HBOC, both methods were compared. Initially, 74% of women, ages 30 to 48 years, had a 10-year breast cancer risk below 5%, but 53% exceeded this threshold at an older age based on the AP approach. Among the women with an initial risk below the threshold, the CP approach revealed that 99% of women exceeded the 5% threshold at the same or an earlier age compared with the AP approach (88% of cases were within the same year or 1 year earlier). The CP approach has been implemented as a user-friendly web application.
Prevention Relevance: The German Consortium for Hereditary Breast Cancer recommends annual breast imaging for women if their 10-year breast cancer risk is 5% or higher. Women who initially do not meet this risk threshold may do so later. We propose a simple method to determine future risks based on initial risk assessments.
Table S3 from ETx-22, a Novel Nectin-4–Directed Antibody–Drug Conjugate, Demonstrates Safety and Potent Antitumor Activity in Low-Nectin-4–Expressing Tumors
Authors: Lopez Marc , Crompot Emerence , Josselin Emmanuelle , Farina Anne , Rubis Marion , Castellano Remy , Fares Joanna , Wehbe Maria , Collette Yves , Charafe Emmanuelle , Blanchin Stéphanie , Romagne François , Pálfi Anikó , Hechler Torsten , Pahl Andreas , Azim Hatem A. , Lhospice Florence , Mamessier Emilie , Bertucci François , Elands Jack , Préville Xavier , Olive Daniel 
Published: November 2024

<p>Supplementary Table 3 shows the affinities (Octet) of anti-hnectin-4 mAbs for monomeric and dimeric human nectin-4 </p>
Detrimental Effect of Acute Hyperglycemia on the Outcomes of Large Ischemic Region Stroke
Authors: Tanaka Kanta , Yoshimoto Takeshi , Koge Junpei , Yamagami Hiroshi , Imamura Hirotoshi , Sakai Nobuyuki , Uchida Kazutaka , Beppu Mikiya , Matsumaru Yuji , Matsumoto Yasushi , Kimura Kazumi , Ishikura Reiichi , Inoue Manabu , Sakakibara Fumihiro , Morimoto Takeshi , Yoshimura Shinichi , Toyoda Kazunori ,   the RESCUE‐Japan LIMIT Investigators
Published: November 2024

Background
Although endovascular therapy (EVT) is effective for large ischemic region strokes, the impact of hyperglycemia remains unclear.

Methods and Results
We analyzed data from the RESCUE‐Japan LIMIT (Recovery by Endovascular Salvage for Cerebral Ultra‐Acute Embolism‐Japan Large Ischemic Core) trial, which randomized stroke patients with Alberta Stroke Program Early Computed Tomography Score of 3 to 5 to EVT versus medical management. Outcomes were compared among patients with normoglycemia (<140 mg/dL), moderate hyperglycemia (≥140, <180 mg/dL), and severe hyperglycemia (≥180 mg/dL) on admission. Among 200 patients (median age 76.5 years, median glucose level 131 mg/dL, EVT 50%), diabetes prevalence was 10.0%, 18.4%, and 71.0% in the groups with normoglycemia (n=120), moderate hyperglycemia (n=49), and severe hyperglycemia (n=31), respectively. Achievement of modified Rankin Scale score 0 to 3 at 90 days was less frequent in the group with severe hyperglycemia (6.5%) than in the groups with normoglycemia (25.0%) and moderate hyperglycemia (24.5%), with adjusted odds ratios (aOR) of 1.48 (95% CI, 0.59–3.72) for moderate and 0.17 (95% CI, 0.03–0.95) for severe hyperglycemia relative to normoglycemia. The risk of symptomatic intracranial hemorrhage was higher for moderate hyperglycemia (6.1%; aOR, 2.86 [95% CI, 0.42–19.71]) and particularly for severe hyperglycemia (25.8%; aOR, 18.59 [95% CI, 2.47–139.87]) compared with normoglycemia (2.5%). Symptomatic intracranial hemorrhage rates were similar for EVT and medical management in normoglycemia (1.6% versus 3.4%) and moderate hyperglycemia (5.0% versus 6.9%), but for severe hyperglycemia, the rate was higher in patients with EVT (36.8%) than in those without (8.3%).

Conclusions
Severe hyperglycemia was associated with worse functional prognosis and increased symptomatic intracranial hemorrhage in large ischemic region strokes.

Registration

URL:
https://clinicaltrials.gov
. Identifier: NCT03702413.
Mediation Analysis of Serum Fibroblast Growth Factor 20 and Poor Prognosis After Ischemic Stroke
Authors: Chen Keyang , Huang Wenting , Hu Beilei , Fu Fangwang , Cao Yungang , Xu Huiqin , Ruan Lixin , Li Yongang , Li Yan , Chen Jun , Liang Fei , Wang Xue , Du Xudong , Lin Li , Li Xiaokun 
Published: November 2024

Background
We aimed to examine the relationship between serum FGF20 (fibroblast growth factor 20) levels and stroke prognosis in a multicenter cohort study.

Methods and Results
Patients with ischemic stroke/transient ischemic attack were prospectively recruited from 5 participating centers and followed up at 3 months and 1 year. FGF20 levels were measured using the ELISA method. The primary outcome was poor stroke functional outcome (modified Rankin Scale score of 3–6), and secondary outcomes included death and composite vascular events. Multivariable logistic regression analysis or Cox proportional hazards regression analysis was employed to estimate the relationship between FGF20 and study outcomes. Mediation analysis was conducted to examine the mediating effects of traditional risk factors on the association between FGF20 and stroke outcomes. A total of 1011 patients with ischemic stroke were included in the study. After adjusting for potential confounding factors, an elevated serum FGF20 level was associated with a reduced risk of the poor outcome and death. Multivariable adjusted spline regression analysis demonstrated a linear correlation between serum FGF20 levels and the stroke outcomes. The incorporation of FGF20 alongside conventional risk factors marginally enhanced the reclassification of adverse outcomes. Renal function and white blood cell count partially mediated the relationship between FGF20 and the prognosis of ischemic stroke.

Conclusions
Elevated FGF20 level is associated with decreased risks of adverse outcomes after ischemic stroke, which was partially mediated by renal function and white blood cells with a modest amount, indicating that serum FGF20 might serve as a promising biomarker for predicting stroke prognosis.

Registration

URL:
https://www.chictr.org.cn
; Unique identifier: ChiCTR2100051104.
Genetic Determinants of Left Atrial Function Are Associated With Stroke
Authors: Vad Oliver B. , Paludan‐Müller Christian , Diederichsen Søren Z. , McKaige Emily A. , Monfort Laia M. , Lundegaard Pia R. , Bertelsen Litten , Andreasen Laura , Svendsen Jesper H. , Olesen Morten S. 
Published: November 2024

Background
While atrial fibrillation (AF) is a key risk factor for stroke, recent studies have suggested that atrial cardiomyopathy may also increase stroke risk in the absence of AF. This study aimed to evaluate genetic determinants for left atrial (LA) function and volumes and risk of stroke.

Methods and Results

Polygenic scores (PGSs) for LA measures were constructed and used in 380 017 individuals in the UK Biobank, without history of ischemic stroke, systemic arterial embolism, or AF at enrollment. Risk of ischemic stroke was estimated using time‐to‐event models, considering all‐cause death and incident AF as competing events. Systemic arterial embolism was investigated as a secondary end point. The PGS for LA passive emptying fraction was associated with risk of ischemic stroke. Individuals with a PGS for LA passive emptying fraction in the lowest quartile had a hazard ratio (HR) of 1.12 for ischemic stroke compared with those in the top quartile (
P
=0.004). These associations were robust in a subgroup free of prevalent cardiovascular disease at baseline (HR for lowest quartile versus top quartile, 1.22;
P
<0.001). No associations were found for 4 other PGSs for LA measures or for risk of systemic arterial embolism. Two‐sample Mendelian randomization was conducted between LA measures and cardioembolic stroke and indicated a protective effect of higher LA functional measurements.

Conclusions
The PGS for LA passive emptying fraction was significantly associated with incident ischemic stroke when considering AF as a competing risk. Consistent results were found in Mendelian randomization analyses. These findings suggest that atrial dysfunction may influence stroke risk independently of AF.
Spiritualisation of the Coronavirus in Africa
Authors: Tinashe Nenjerama Theophilus , Matanzima Joshua 
Published: November 2024

Abstract
The advent of the coronavirus pandemic shook the globe. The prevalence of the pandemic was interpreted differently in different quarters. African religious leaders also interpreted the pandemic spiritually. In the beginning of the pandemic the prophets reiterated their past prophecies about the disease from the sea that would rock the world. For many contemporary prophets the emergence of this disease was a confirmation of prophecy. This paper assesses the ways in which coronavirus has been spiritualised. In so doing it underscores the inextricable nexus between disease and religion. The study uses the case of the Nigerian prophet TB Joshua and the Zimbabwean prophet Emmanuel Makandiwa, and critically engages with the myriad ways by which coronavirus was interpreted through a spiritual lens by both. Where relevant, the study compares their prophecies. The article argues that some of the theologies behind the interpretation call for a close analysis in terms of their impact on the community of the followers of both Joshua and Makandiwa. Critical Discourse Analysis is used to analyse the prophesies of these two prophets about the virus during the pandemic.
The Role of the Bharatiya Janata Party in Shaping India’s Foreign Policy towards the European Union since 2014
Authors: Jaskólska Aleksandra 
Published: November 2024

Abstract
The article aims to analyze the role of the Bharatiya Janata Party (BJP) in shaping India’s foreign policy towards the European Union (EU). The article hypothesizes that the BJP, the political party in power since 2014, is the main domestic political actor that impacts India’s foreign policy towards the EU. Its strategy towards the EU is influenced not only by domestic factors but also by external ones. Firstly, the article assesses the formal and informal mechanisms the BJP uses to shape Indian foreign policy. Next, it identifies the main factors influencing the BJP’s foreign policy toward the EU. Finally, it evaluates the importance of the BJP, as an example of a domestic actor, in forming India’s foreign policy toward the EU.
Evaluation of the effect on stroke mechanism, stroke recurrence and clinical outcome in stroke patients with basilar artery atherosclerosis: A single centre retrospective observational study
Authors: Dinç Yasemin , Özpar Rifat , Mesut Gizem , Hojjati Farid , Gökçe Serhat , Siğirli Deniz , Akarsu Emel Oğuz , Sarıdaş Furkan , Hakyemez Bahattin , Bakar Mustafa 
Published: November 2024

Objectives Basilar artery atherosclerotic plaque is the predominant cause of stroke in the posterior circulation. İscheamic stroke caused basilar artery atherosclerosis faces a high risk of recurrence despite optimal medical treatment, which might lie in the less than ideal recognition of underlying stroke mechanism and lack of individualized treatment for strokes of different mechanisms. We aim in this study to investigate the effect on stroke mechanism, stroke recurrence and clinical outcome in stroke patients with basilar artery atherosclerosis. Methods In this study, 107 ischaemic stroke patients with atherosclerotic stenosis in the BA who were followed up in Uludag University Faculty of Medicine between 1 January 2019 and 1 January 2022. The study was conducted retrospectively and observationally. Results According to the results of our study, the degree of stenosis in atherosclerotic stenosis of the symptomatic basilar artery was found to be an independent risk factor for stroke recurrence. Independent risk factors for unfavourable clinical outcomes in these patients were determined as female gender, stenosis being in the proximal segment, stroke mechanism being from artery to artery embolism, and congestive heart failure. Conclusion The most striking result of our study is that clinical outcome was found to be closely related to the female gender, the stroke mechanism being artery-to-artery embolism, and the stenosis is in the proximal segment. If stroke mechanisms were evaluated more clearly, it would likely help provide individualised treatments.
The more, the merrier? Young adults’ sibling relationship quality in medium to large families
Authors: Jensen Alexander C. , Ashby Sarah , Noorda Naomi M. , Jasperson Jennie 
Published: November 2024

Approximately 80% of individuals from the United States have at least one sibling. Of those with siblings, a little more than half have two or more siblings. Yet, research on siblings across the life course, including young adulthood, has focused primarily on sibling dyads rather than larger sibling groups or multiple sibling dyads from the same family. The overarching aim of the current study was to explore the form and impacts of entire sibling groups and multiple sibling dyads for young adults with two or more siblings. Data were collected from an online survey of 975 young adults aged 19–29 years from across the United States ( M age = 25.43, SD = 2.52; 48% male; 73% white). Results showed that participants reported greater variation in sibling relationship quality when their siblings were not all the same gender and when their siblings had greater differences in age. Young adults were more likely to report a close aged sibling as the sibling with whom they have the closest relationship or most conflict. Relationship quality also showed links with psychosocial outcomes. In some cases, greater variation in sibling conflict and closer relationships with one particular sibling were linked to better outcomes. More conflict was linked to poorer outcomes. Multiple effects were moderated by gender, gender of the sibling, and characteristics of the entire sibling subsystem. Overall, our findings suggest that sibling relationships in medium to larger families are multifaceted and complex. Our results are in line with a family systems perspective that siblings have unique roles but that sibling dyads within families mutually influence and interact with one another.
A qualitative analysis of the use of intraoperative acupuncture for patients with nosocomephobia
Authors: Thor Pa , Moreno Andrew , Zhong Haoyan , Sheetz Miriam , Popovic Marko , Strickland Sabrina M , Ast Michael P , Cheng Stephanie I 
Published: November 2024

Background: Nosocomephobia, a type of posttraumatic stress disorder (PTSD), is a diagnosis of an extreme fear of hospitals that can hinder current/future medical care. There is little research on how nosocomephobia affects elective surgery or how acupuncture can help patients cope. Methods: Using the transactional model of stress/coping, this qualitative case study examined the role of acupuncture in nosocomephobia patients’ elective surgery appraisal processes. Two patients were interviewed about their nosocomephobia and prior hospital experiences. Six reviewers coded interview transcripts line-by-line using Dedoose software. Reviewers labeled meaningful words, phrases and sentences and produced over 600 codes. Reviewers discussed/identified themes by grouping similar codes and resolving discrepancies. A thematic analysis was then used to develop final themes. Pseudonyms were assigned to protect patient privacy. Sophie had avascular necrosis in both hips and suffered PTSD from a previous traumatic event. Intraoperative acupuncture calmed her hospital anxiety, allowing her to have both hips replaced. Olivia had experienced PTSD and hospital phobia since she was 12 years old. Acupuncture reduced her anxiety surrounding a necessary knee arthrotomy and osteochondral allograft. Results: Thematic analysis showed how nosocomephobia impacted patients’ views of surgery and distinguished between their unique fear rationale. The transactional model of stress/coping illustrated patients’ appraisal process from surgery (stressor) to coping (acupuncture) to reappraisal (mental state). Conclusion: Procedural visits can be stressful due to already heightened anxiety. Although no definitive conclusions can be drawn from this small, uncontrolled case series, acupuncture may represent a safe, noninvasive way for nosocomephobia patients to manage preoperative anxiety.
Total Thrombus-Formation System in Patients with Peripheral Artery Disease
Authors: Pfrepper Christian , Franke Careen , Metze Michael , Weise Maria , Siegemund Annelie , Siegemund Roland , Federbusch Martin , Henschler Reinhard , Petros Sirak , Konert Manuela 
Published: November 2024

The Total Thrombus-formation Analysis System (T-TAS) is an automated device using coated microchips to assess thrombus formation under flow conditions. Its value to monitor coagulation function in patients under antiplatelet therapy awaits further clarification. This study evaluated T-TAS to detect response to dual antiplatelet therapy (DAPT) in patients with peripheral artery disease (PAD). T-TAS using the platelet-chip (PL-chip) and atheroma-chip (AR-chip) was performed in 60 patients with PAD on the day after lower extremity revascularization. Results were compared with light transmission aggregometry (LTA) and multiple electrode aggregometry (MEA, ADP- and ASPI-test). To determine T-TAS reference ranges, 30 healthy blood donors were enrolled. The area under the curve of the PL-chip (AUC-PL) was outside the reference range in 91.2% and AUC-AR in 21.1% of the PAD patients. Low responders in MEA ASPI, MEA ADP or both tests and low responders in LTA induced by ADP had a significantly higher AUC-PL compared to responders (204 vs 70, p = .016 and 140 vs 32, p < .001), respectively. Median AUC-PL in low responders in LTA and MEA, LTA or MEA and in responders in LTA and MEA was 301, 104 and 32 (p = .001), respectively. Our results suggest that the PL-chip can continuously assess the level of response to DAPT and might be helpful to monitor PAD patients.