bluuebunny/crossref_metadata_2025_split huggingface dataset:
The RNA-binding protein DND1 acts sequentially as a negative regulator of pluripotency and a positive regulator of epigenetic modifiers required for germ cell reprogramming
Authors: Ruthig Victor A. , Friedersdorf Matthew B. , Garness Jason A. , Munger Steve C. , Bunce Corey , Keene Jack D. , Capel Blanche 
Published: June 2019

ABSTRACT
The adult spermatogonial stem cell population arises from pluripotent primordial germ cells (PGCs) that enter the fetal testis around embryonic day (E)10.5. PGCs undergo rapid mitotic proliferation, then enter prolonged cell cycle arrest (G1/G0), during which they transition to pro-spermatogonia. In mice homozygous for the Ter mutation in the RNA-binding protein Dnd1 (Dnd1Ter/Ter), many male germ cells (MGCs) fail to enter G1/G0 and instead form teratomas: tumors containing many embryonic cell types. To investigate the origin of these tumors, we sequenced the MGC transcriptome in Dnd1Ter/Ter mutants at E12.5, E13.5 and E14.5, immediately prior to teratoma formation, and correlated this information with DO-RIP-Seq-identified DND1 direct targets. Consistent with previous results, we found DND1 controls downregulation of many genes associated with pluripotency and active cell cycle, including mTor, Hippo and Bmp/Nodal signaling pathway elements. However, DND1 targets also include genes associated with male differentiation, including a large group of chromatin regulators activated in wild-type but not mutant MGCs during the E13.5 and E14.5 transition. Results suggest multiple DND1 functions and link DND1 to initiation of epigenetic modifications in MGCs.
Thyroid auto immune antibodies in children with Type-I Diabetes mellitus in relation to diabetes control
Authors: Ridha Muneera Fadhil , Al Zubaidi Munib Ahmed 
Published: June 2019

Background & Objective: As an autoimmune disease, Type-1 diabetes mellitus (DM) may be associated with other autoimmune disorders, the presence of thyroid antibodies could be negatively impact the diabetic control. Our objective was to investigate thyroid autoimmunity in a cohort of children and adolescents with Type-1 diabetes and the Influence of the presence of thyroid autoimmune abnormalities on the control of diabetes in group of Iraqi pediatric patients with Type-I D.M.
Methods: This study was conducted at the Medical City Complex, Children Welfare Hospital, Baghdad, Iraq. This study was carried out from the first of January 2016 till the end of September 2017. Data were analyzed from 150 patients with Type-1 diabetes, aged 1–18 years who were treated and are coming for regular follow up in the diabetic clinic. Thyroid functions tests, Antibodies to thyroglobulin (anti-TG) and thyroperoxidase (anti-TPO) were measured, documented and correlated with diabetic control according to glycated haemoglobin (HbA1c) level.
Results: In the total of 150 patients, positive Antibodies to thyroglobulin (anti TG) were more in ≤3 years duration group of Diabetes mellitus( DM) and negative anti TG was less in the >3 years duration of DM group with statistically significant results (p=0.043), Regarding the distribution of thyroid antibodies (AB) according to HbA1c group, there was progressive positive anti thyroperoxidase (anti TPO) titer with glycemic status, good glycemic control had the lowest positive anti TPO titer and poor glycemic control group had the highest positive anti TPO titer and the result was statistically significant (p=0.048).
Conclusions: Thyroid autoimmunity may be associated with poor diabetic control and elevated TSH levels, indicating subclinical hypothyroidism that my affect the diabetic control.
doi: https://doi.org/10.12669/pjms.35.4.192
How to cite this:Ridha MF, Al-Zubaidi MA. Thyroid auto immune antibodies in children with type I Diabetes mellitus in relation to diabetes control. Pak J Med Sci. 2019;35(4):969-973. doi: https://doi.org/10.12669/pjms.35.4.192
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Phenotypic detection of Extended Spectrum β-Lactamases (ESBL) among gram negative uropathogens reveals highly susceptibility to imipenem
Authors: Mohammed Isra , Abass Elfadil 
Published: June 2019

Objective: We aimed to determine antibiotic susceptibility patterns of ESBL- and non-ESBL bacteria isolated from pregnant women with UTI in antenatal wards in Khartoum State, Sudan.
Methods: This cross-sectional study was conducted during April-July 2016 at different hospitals in Khartoum State. Mid-stream urine samples were obtained from 150 hospitalized pregnant women and cultured on CLED (Cystine Lactose Electrolyte Deficient) agar. Microorganisms were identified using standard microbiological procedures. Isolated Gram-negative bacteria were tested for antibiotic susceptibility and ESBL screening using modified Kirby- Bauer method and Double Disc Synergy Test (DDST) respectively.
Results: Urine culture revealed positive results in 33/150 (22%) and the most prevalent isolates were Gram negative bacteria (18/33, 54.5%). Among gram-negative bacteria, isolates of E. coli were the most prevalent accounting 66.6% (12/18) followed by K. pneumoniae (4/18, 22.2%) and K. oxytoca (2/18, 11.1%). ESBL was detected in 8/18 (44.4%) of the Gram-negative isolates. Of note, imipenem was the most susceptible antibiotic for ESBL-producer and non-ESBL producer Gram negative isolates, accounting 100% susceptibility for both bacterial groups. Overall susceptibility rates were also high for ciprofloxacin (13/18, 72.2%). In other hand, co-trimoxazole and amoxicillin showed high resistance pattern for ESBL-producer and non-ESBL producer isolates; 27.8%, 44.4% and 38.9%, 38.9% susceptibility rates of co-trimoxazole and amoxicillin for ESBL-producer and non-ESBL producer isolates, respectively.
Conclusions: Imipenem remains the most powerful option for ESBL- and non-ESBL bacteria causing UTIs in pregnant women. However, due to tremendous increase of antibiotic-resistant, antibiotic-susceptibility testing is recommended as a routine investigation for admitted pregnant women.
doi: https://doi.org/10.12669/pjms.35.4.207
How to cite this:Mohammed I, Abass E. Phenotypic detection of Extended Spectrum β-Lactamases (ESBL) among gram negative uropathogens reveals highly susceptibility to imipenem. Pak J Med Sci. 2019;35(4):1104-1109. doi: https://doi.org/10.12669/pjms.35.4.207
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
CRISE ORGÃNICA, HEGEMONIA E REVOLUÇÃO PASSIVA GRAMSCIANA
Authors: Militão Maria Socorro Ramos 
Published: June 2019

Visando compreender os fatores que originaram o Fascismo na Itália e as derrotas do movimento operário na Europa, o filósofo italiano Antonio Gramsci promoveu uma análise microscópica desses fenômenos e das dimensões que eles atingiram no período da Primeira Guerra e no posterior, assim pôs-se a investigar os fatores que se coligaram e caracterizaram a crise, desencadeada por eles. Essas seriam algumas das questões que receberiam a atenção doautor sardo em sua obra Cadernos do Cárcere, na qual construiria preciosas anotações acerca da crise capitalista que, para ele, não seria apenas uma crise esporádica própria ao sistema, mas uma crise orgânica por ser acompanhada de perda de poder hegemônico. Naquela obra, mostra que a assim chamada crise de hegemonia também desencadeia crises econômicas, políticas, de comando, de autoridade, etc. Por isso, ela deve ser interpretada como um movimento orgânico que se desenvolve em um processo histórico complexo, com sua multiplicidade de componentes e inter-relações em nível global, e não apenas como fenômeno imediato e conjuntural, daí ser provocada por um somatório de questões que se acumularam molecularmente. O autor dos Cadernos aponta como fracasso da política da classe dirigente a imposição do consenso dasgrandes massas pela força; a organização política de grandes massas anteriormente passivas e que passam a se movimentar, embora sem uma vontade política precisa; ou ainda porque as forças antagônicas se mostraram incapazes de organizar em seu favor esta desordem. Diante desse quadro é que se apresenta o objetivo deste artigo: explicitar o processo de desenvolvimento da crise orgânica e a inerente perda de hegemonia decorrente dela, e, com efeito, demonstrar a possibilidade de construção da hegemonia dos e para os subalternos. A investigação em âmbito filosófico-político terá como base teórica o legado gramsciano e, como método de orientação da pesquisa, a filosofia da práxis.
O ENIGMA ONTOLÓGICO DA MERCADORIA COMO PONTO DE PARTIDA D’O CAPITAL DE MARX
Authors: Pereira Leonardo Da Hora 
Published: June 2019

Apesar de ser tido normalmente como um livro de economia, de teoria social ouaté mesmo de história, O Capital de Marx possui elementos de grande interesse filosófico. Se adotarmos esse último ponto de vista, torna-se inevitável uma abordagem do primeiro capítulo desta obra, na medida em que ele introduz uma tese curiosa, algo como um enigma ontológico: como algo pode existir de dois modos diferentes, concomitantes e relacionados entre si? Pois esse é o caso da mercadoria, analisada por Marx neste primeiro capítulo. Neste artigo, iremospropor uma leitura deste capítulo com vistas a esclarecer este modo dúplice de existência da mercadoria. Esta tentativa de esclarecimento é a nosso ver relevante, tendo em vista que tal “qüiproquó ontológico” já suscitou inúmeras controvérsias e tal enigma é extremamente importante para a compreensão do resto da obra e da própria dinâmica capitalista, tal como pensada por Marx; não à toa, a explicação do modo de ser da forma-mercadoria se encontra logo no começo do Capital.
ENTRE O DISCURSO E A ONTOLOGIA DO SER SOCIAL: POSSIBILIDADES DE UM DEBATE
Authors: Sombra Laurenio Leite 
Published: June 2019

O objetivo deste artigo é fazer um contraponto entre a teoria do discurso de Ernesto Laclau e Chantal Mouffe e a ontologia do ser social de Lukács. Tentamos expor que a dualidade estabelecida por Laclau e Mouffe entre contingência e necessidade, categorias fundamentalmente lógicas, não abarca a ontologia do ser social, que constitui uma objetividade que “tem a sua própria lógica”, nem da necessidade nem da contingência. Lukács, assim como Marx, parte do trabalho como categoria central da passagem de uma ontologia da natureza paraa ontologia do ser social. Aqui se argumenta que a linguagem tem o mesmo peso ontológico do trabalho. Inserindo-se essa dimensão na ontologia de Lukács, alguns dos elementos da teoria do discurso de Laclau e Mouffe, apesar de suas insuficiências, podem ser repensados.
Ship Domain in Various Visibility Conditions in Restricted Waters
Authors: Pietrzykowski Zbigniew , Siemianowicz Marek , Wielgosz Mirosław 
Published: June 2019

AbstractShip domain is one of navigational safety assessment criteria. Its shape and size depend on many factors, including visibility. This article examines the influence of visibility on the shape and dimensions of ship domain in restricted waters. The research was conducted using a simulator of the ECDIS system with the participation of experts’ navigators. The domains of ships in good and restricted visibility have been compared.
Concept of LNG Transfer and Bunkering Model of Vessels at South Baltic Sea Area
Authors: Gucma Maciej , Bąk Andrzej , Chłopińska Ewelina 
Published: June 2019

AbstractAt first part of the article methods of SOx (sulphur oxides) emission reduction is presented along with the description of LNG (Liquefied Natural Gas) as a bunker fuel for vessel. Assumptions for the methods of bunkering between different LNG driven vessel and bunker means is presented. Last part presents assumptions for optimization method and detailed factors to be used in the further work. Optimization of Location-Route Planning (LRP) model with dynamics is presented as starting idea for next steps.
The Identification of Possible Applications of the E-Loran System
Authors: Czaplewski Krzysztof , Weintrit Adam 
Published: June 2019

AbstractGlobal Navigation Satellite Systems (GNSS) more and more affect many areas of human activity in the world. Every day human activity around the world depends upon satellite systems for positioning, navigation and timing. As these systems are commonly used further efforts must be made to make GNSS more immune to on occurring more and more frequently incidents of jamming and spoofing. It seems that eLoran system is currently the best the technical and scientific solution to allowing for effective protection of the Global Navigation Satellite Systems. Last year the authors presented eLoran system as a potential tool for transmission of the national time signal [Curry et al., 2017]. This time the authors present abilities of additional use of the eLoran as a back-up system for GNSS.
Conversion of A Second- To First-Order Linear Nomoto Model in the Light of Zigzag Manoeuvre Performance
Authors: Artyszuk Jarosław 
Published: June 2019

AbstractThe problem of considerable difference between the first- and second-order linear Nomoto models is undertaken, not well covered in literature so far. If the former approximates the latter (better one, of a sound hydrodynamic interpretation) for some reasons, its parameters can not be easily derived from the other one, except for some specific rare cases. For such an identification purpose, we can use a simulated zigzag response and the classic procedure proposed by Nomoto in 1960. However, the first-order model thus developed yields somehow redefined constants against the original model, which lose their normal hydrodynamic (or kinematic) sense. In other words, it is very sensitive to the manoeuvre type on input, being therein the zigzag test. Therefore, the model is allowed to be only used for simulating motions essentially similar to the input zigzag. In other words, the identification procedure works like a blind curve-fitting and the first-order model (in contrast to second-order one) is inadequate for reflecting arbitrary manoeuvres, even for mild rudder as to be within ‘linear’ assumptions.This study examines systematically and in detail such an incompatibility of the first order model in that it presents the conversion charts from the standpoint of 10°/10° zigzag test matching. One can receive higher or lower values for the parameters of first-order model, versus the second-order one, depending on the T3/T2 ratio of the latter model.
LIFE+2010 QUADMAP Project: results obtained from the analysis of data collected during the application of the new methodology to the pilot quiet areas
Authors: Bartalucci Chiara , Borchi Francesco , Carfagni Monica , Governi Lapo , Luzzi Sergio , Aspuru Itziar , Gaudibert Piotr , Wolfert Henk 
Published: June 2019

Abstract
Since the 90s, quiet areas have commonly been considered as places to be acoustically preserved or where acoustic interventions should be implemented to reduce noise levels. With the enforcement of the Environmental Noise Directive in 2002, a formal definition of a ‘quiet area in agglomeration’ and a ‘quiet area in open country’ was established. However, many Member States complained about the absence of guidelines regarding the identification and management of quiet areas. The LIFE QUiet Areas Definition and Management in Action Plans (QUADMAP) project started in 2011 to contribute to the Directive’s incomplete requirements for quiet areas. The project’s main result has been the introduction of a flexible methodology for the selection, analysis and management of quiet areas in agglomeration in which both acoustic and nonacoustic parameters are evaluated. The current paper illustrates the analyses carried out on the data collected during the application of the selection, analysis and management phases of the developed methodology in the different pilot cases selected during the Project. Mentioned analysis are aimed at verifying the benefits of the proposed complementary selection criteria (‘relative quiet urban areas’ identification criteria and ‘homogeneous urban areas’ subdivision criteria), at defining the measurement periods most representative of the areas and the acoustic and nonacoustic parameters to be considered as the most significant.
Performance Characteristic Modeling for 2D Compressor Cascades
Authors: Fei Teng , Ji Lucheng , Yi Weilin 
Published: June 2019

Abstract
The flow field in a compressor cascade is very complex owing to the highly 3D, turbulent, and viscous properties. However, in the through-flow analysis method, the viscosity effects are taken into account using empirical models. These models were based on experimental results for early blades. However, the blade types in modern compressors are quite different from those in older compressors. Therefore, it is not possible to predict the performance of modern compressors using the old empirical models. In this study, several multiple circular-arc (MCA) blades commonly used in modern compressors were simulated. After the simulations, a database of the cascade performance was built. Based on this database, some new models were established to predict the performance of modern cascades using regression analysis methods and an artificial neural network (ANN) method. The accuracy of all these new models is high enough for use in engineering applications.
Recurrent spondylodiscitis secondary to hallux osteomyelitis
Authors: Staniszewska Aleksandra , Ballingall Elizabeth , Schnatterbeck Peter , Lattimer Christopher R , Amin Amit , Lynn William , Mehta Sanjeev 
Published: June 2019

Foot infections are the commonest complication of diabetes mellitus requiring hospitalisation. Despite local osteomyelitis being the most frequent sequel of a diabetic foot infection, there is emerging evidence to suggest that local disease may lead to distant infections. In this report we present a case of recurrent thoracic spine spondylodiscitis due to left hallux osteomyelitis in a man with type 2 diabetes. This case illustrates the importance of considering spondylodiscitis as a differential diagnosis in patients presenting with diabetic foot infection and complaining of acute severe back pain.
Effect of the Number of Years of Soil Exploitation by Saffron Cultivation in Morocco on the Diversity of Endomycorrhizal Fungi
Authors: El Aymani I. , El Gabardi S. , Artib M. , Chliyeh M. , Selmaoui K. , Ouazzani Touhami A. , Benkirane R. , Douira A. 
Published: June 2019

The diversity of endomycorrhizal fungi in the rhizosphere of Crocus
sativus has been studied at five sites in the Taliouine region
(Tinfat), located in Taroudant Province (Morocco), according to the number of
years of soil exploitation by Saffron cultivation. In all sites, the roots of
Crocus sativus carry structures of endomycorrhizal fungi.
Root mycorrhizal frequencies are very high in site 1 (93.33%); site 2 (96.67%);
site 4 (90%) and in site 6 (93.33%). In these sites, the spore density is,
respectively, 39, 58, 138, 99 spores / 100 g of soil. The frequency of root
mycorrhization is lower at the site (76.66%) which also exhibited a spore
density of 27 spores / 100 g of soil.
The identification of isolated spores made it possible to note the presence of 36
species belonging to 6 genera: Glomus (15 species),
Acaulospora (10 species), Scutellospora (6
species), Gigaspora (2 species), Pacispora (2
species), Entrophospora (1 species). Species such as
Glomus clarum, G. etunicatum, G.
aggregatum, G. intraradices, Acaulospora
laevis, Scutellospora coralloidea, were present in
all studied sites.
The greatest richness of MA fungi was registers in the site at four successive
years of exploitation by Saffron (24 species), with a Shannon diversity index H
‘= 2.82 which is the highest among all studied sites, followed by the site at
six years of occupation by Saffron (21 species), with H ‘= 2.61, while the
lowest number of species was recorded in sites of two, three and ten years of
exploitation of sol by Saffron, with H ‘= 1.77, respectively; 2.12 and 2.44.
This decrease in endomycorrhizal species richness confirms that Crocus
sativus residues are probably the cause. In fact, the prolonged
occupation of plots with safrana has an allelopathic effect on mycoflora and on
the yield of Saffron.
Pengaruh Lama Penyimpanan dan Penambahan Asam Sitrat pada Nasi di Rice Cooker terhadap Kandungan Nutrisi
Authors: Handayani Hany , Rosahdi Tina Dewi , Viera Baiq El 
Published: June 2019

Umumnya, nasi merupakan jenis makanan yang dikonsumsi oleh sebagian masyarakat Indonesia. Nasi dimasak oleh masyarakat menggunakan alat pemasak nasi otomati atau disebut dengan rice cooker. Nasi dimasak tanpa dan dengan asam sitrat kemudian dihangatkan selama 48 jam dan dianalisis pada jam penghangatan ke-0, 24 dan 48 jam. Penelitian ini bertujuan untuk mengidentifikasi pengaruh lama penyimpanan dan penambahan asam sitrat pada nasi di rice cooker terhadap kadar air, kadar abu, kadar lemak, kadar nitrogen total, karbohidrat total, serat kasar dan menentukan Bahan Ekstrak Tanpa Nitrogen (BETN) pada nasi tanpa dan dengan asam sitrat. Lama penyimpanan nasi (0, 24, dan 48 jam) di rice cooker mempengaruhi kadar air, kadar lemak total, kadar nitrogen total, karbohidrat total, serat kasar dan kadar BETN tetapi tidak mempengaruhi kadar abu. Penambahan asam sitrat pada nasi di rice cooker mempengaruhi kadar lemak total dengan penyimpanan selama 0 ke 24 mengalami penurunan, sedangkan pada penyimpanan 24 ke 48 jam mengalami kenaikan kadar lemak total.
Kinerja Susunan dan Jumlah Elemen Peltier pada TEC Alat Transportasi Ikan Segar
Authors: Widianto Tri Nugroho , Mahendra Caesar 
Published: June 2019

AbstrakKinerja cara penyusunan dan jumlah elemen peltier pada pendingin termoelektrik (TEC) alat transportasi ikan segar telah diuji. TEC alat transportasi ikan segar terdiri dari komponen utama yaitu elemen peltier, heatsink, kipas, bracket alumunium dan heat pipe. Uji kinerja dilakukan terhadap susunan dan jumlah elemen peltier TEC alat transportasi ikan segar dengan variasi dua buah TEC dengan elemen peltier tunggal, dua buah TEC dengan elemen peltier ganda dan empat buah TEC dengan elemen peltier tunggal. Parameter yang diamati meliputi suhu ruang penyimpanan ikan, suhu heatsink dan kebutuhan energi TEC. Pengukuran dilakukan selama 120 menit dengan interval pengukuran setiap 10 menit. Suhu ruang peti penyimpanan ikan dengan dua buah TEC peltier ganda adalah 18,8 °C, dua buah TEC peltier tunggal sebesar 13,5 °C dan empat buah TEC peltier tunggal sebesar 8,5 °C. Kebutuhan energi TEC dengan dua buah elemen ganda sebesar 46 Watt, TEC dengan 2 buah elemen peltier tunggal sebesar 83 Watt, sedangkan pada 4 elemen peltier tunggal 166 Watt. Performance of Arrangement and Number the Peltier Elements on Refrigerated Fish Container TECAbstractPerformance of arrangement and number of peltier elements on the refrigerated fish container TEC (thermoelectric cooler) had been tested. The TEC of refrigerated fish container was composed of peltier elements, a heatsink, a fan, an aluminum bracket, and a heat pipe. The arrangement and number of peltier element variations in each refrigerated container box were two TEC composed of a single peltier element, two TEC composed of dual peltier element and four TEC composed of a single peltier element. Performance test was conducted by measuring temperature of box container, temperature of heatsink, and the energy consumption of TEC. Performance test carried out at every 10 minutes for 120 minutes. Temperature of refrigerated container box composed of two TEC with dual peltier element was 18.8 °C, two TEC with single peltier element was 13.5 °C and four TEC with single peltier element was 8.5 °C. The energy consumption of refrigerated container box of two TEC composed dual peltier element was 46 Watts, two TEC composed of single peltier element was 83 Watts and four TEC composed of single peltier element were 166 Watts.