bluuebunny/crossref_metadata_2025_split huggingface dataset:
The in vitro cross-reactivity and blood coagulation potential of recombinant porcine factor VIII in Japanese patients with acquired hemophilia A
Authors: Takeyama Masahiro , Sasai Kana , Miyaguchi Yasuo , Ogiwara Kenichi , Furukawa Shoko , Shimonishi Naruto , Nakajima Yuto , Ueda Hitoshi , Nogami Keiji 
Published: October 2024

Abstract
Recombinant porcine factor VIII (rpFVIII) is a hemostatic agent for acquired hemophilia A (AHA). Cross-reaction of auto-antibodies against rpFVIII has been reported, although no data are available in Japanese patients. This study investigated the cross-reactivity and coagulation potential of rpFVIII in plasma samples from Japanese patients with AHA. Cross-reactivity was calculated as the ratio of anti-porcine FVIII inhibitor titer (pFVIII-INH) to human FVIII inhibitor titer. Comprehensive coagulation potential was assessed by clot waveform analysis (CWA) and thrombin generation assay (TGA) in samples spiked with rpFVIII (equivalent to 200 U/kg). Nine of 16 plasma samples (56.3%) had positive pFVIII-INH, with a median cross-reactivity of 1.2%. FVIII activity (FVIII:C) was restored to > 100% in all samples upon spiking with rpFVIII, but was weakly correlated with pFVIII-INH. CWA parameters and most TGA parameters were restored to normal upon spiking with rpFVIII; correlation of these parameters with FVIII:C was similar to that observed in controls. Overall, cross-reactivity to rpFVIII in Japanese patients was similar to that reported in Caucasian patients. Our results suggest that an initial clinical dose of 200 U/kg rpFVIII could restore coagulation potential to normal, and that FVIII:C monitoring after rpFVIII administration may be more informative than pFVIII-INH before administration.
“It Was a Complete Violation of Everything”: LGBT + Veterans’ Experiences of Discrimination and Oppression Through the Exemptive UK Military “Gay Ban” Policy
Authors: McGill Gill , Allen Shannon , Osborne Alison K. 
Published: October 2024

Abstract
Introduction
This is the first empirical study carried out in the UK to examine the devasting impact of the policy to ban all gay, lesbian, bisexual and transgender personnel under exemptive military laws and their resultant support needs as military veterans. The so-called “gay ban” policy was enforced with the rationale that homosexuality was incompatible with military service.

Methods
In the UK between 2021 and 2022, 15 LGBT + veterans took part in semi-structured interviews and 101 LGBT + veterans completed an online survey. The findings were triangulated to provide a comprehensive understanding of the impact of the “gay ban” policy.

Results
Three key overarching themes were identified: Emotional Impact, Changing to Adapt and Adapting to Change and Aftermath: Barriers to Help-Seeking.

Conclusions
Social cohesion, established during military service, was limited upon leaving the Armed Forces and LGBT + veterans reported feeling a loss of their identity and the ability to foster social relationships. The policy ban facilitated discrimination and harassment, causing emotional distress, mental ill health, social isolation and limited access to appropriate support following transition.

Policy Implications
Despite the lifting of the “gay ban” policy over 20 years ago, how inclusivity is represented in a historically heteronormative institution is unclear. The “gay ban” policy was weaponised with strategic power, leading to long-term, negative psychological consequences for those who were disempowered by the ban. Therefore, it is essential that confidence is restored, and that policy and institutional-level changes recognise the historical harm for the future of LGBT + military personnel and veterans. These findings will help to raise awareness and increase knowledge and, in turn, contribute to improving access and engagement with service provision and support.
Abstracts Najaarsvergadering NVU, 8 november 2024
Authors:   Bohn Stafleu van Loghum
Published: October 2024

SamenvattingDeze studie onderzoekt de impact van de intraoperatieve katheterdiameter op postoperatieve uitkomsten na een distale hypospadie-operatie bij kinderen. Complicatie-percentages en maximale flow (Qmax) worden geëvalueerd.
The lattice of ideals of certain rings
Authors: Savin Diana 
Published: October 2024

AbstractLet A be a unitary ring and let $$(\mathbf {I(A)},\subseteq )$$

(

I
(
A
)

,
⊆
)

be the lattice of ideals of the ring A. In this article, we will study the property of the lattice $$(\mathbf {I(A)},\subseteq )$$

(

I
(
A
)

,
⊆
)

to be Noetherian or not, for various types of rings A. In the last section of the article, we study certain rings that are not Boolean rings, not fields, but all their ideals are idempotent.
Recommendations for patch testing with patient’s own materials in occupational dermatology
Authors: Bieck Cara , Obermeyer Lara , Dicke Katja , Alberts Antje , Skudlik Christoph , John Swen Malte , Brans Richard 
Published: October 2024

AbstractAllergic contact dermatitis is one of the most common occupational skin diseases. Due to the limited availability of commercial patch test preparations, patch testing patient’s own material (POM) is of great importance in the diagnosis of occupational contact dermatitis. In a research project (FB 317b) funded by the German Social Accident Insurance (DGUV), a comprehensive assessment of the quality of patch testing with POM in individuals with suspected occupational skin diseases was carried out for the first time in Germany. The initial results show considerable deficiencies in the documentation and in some cases also in the performance of patch testing POMs. Therefore, recommendations for patch testing POM and in particular patch testing with workplace materials are presented.
Postgenomic understandings of fatness and metabolism
Authors: Chellappoo Azita 
Published: October 2024

Abstract‘Obesity’ has, for decades, been a subject of intense scientific and public interest, and remains a key target for postgenomic science. I examine the emergence of determinism in research into ‘obesity’ in the postgenomic field of metabolomics. I argue that determinism appears in metabolomics research in two ways: firstly, fragmentation and narrow construal of the environment is evident in metabolomics studies on weight loss interventions, resulting in particular features of the environment (notably, dietary intake) having outsized influence while the wider social environment is neglected. Secondly, studies aiming to characterize the metabolic signature of ‘obesity’ are guided by a commitment to a deterministic connection between ‘obesity’ and dysfunction, leading to a neglect or distortion of metabolic heterogeneity across individuals regardless of body size.
Complexity and Complex Hope: Thinking Critically and Well in Education
Authors: McChesney Katrina , Locke Kirsten 
Published: October 2024

AbstractAs a thinker and scholar, Martin Thrupp was attuned to the complexity of real-world situations and challenges in education. Things were never simple, and there was never just one thing going on. This has been one of the characteristics we have most admired about Martin. In this piece, we articulate some of what we have learned from Martin and consider what it might mean to think critically and well about education in our present moment and context. We identify a number of directions in which we might all think—and seek to think critically and well—following Martin’s example. We reflect on how Martin, as a careful and critical thinker, was not always popular (including with governments and research fashions of the day) and was not always certain of the best way forward, yet remained committed to ideals of complex hope and the importance of us all raising our heads to contribute.
Exploring Partial Disclosure in Research: Challenges, Justifications, and Recommendations for Ethical Oversight
Authors: Akuma Ifeanyichukwu , Vaswani Vina 
Published: October 2024

Abstract
Deception in research is contentious, as ethical codes stress informed consent, yet complete disclosure may jeopardise validity. Indian Council for Medical Research (ICMR) guidelines classify deception into active, incomplete, and authorised forms. This study explores the ethical justification for incomplete (partial disclosure), permissible instances, and the dilemma faced by ethics committees in balancing scientific rigour and participant protection. The qualitative, non-experimental cross-sectional research, using in-depth interviews, identifies themes through thematic analysis. Findings reveal challenges for ethics committees, as incomplete information hampers understanding, amongst others. The paper proposes an ethics committee framework, urging researchers to minimise or avoid partial deception and recommending institutional awareness campaigns and standard operating procedures for minimal-harm studies using partial disclosure. Therefore, it proposes that partial disclosure should be justified by the 3Vs—value, validity, and veracity to preserve research integrity.
Methodological challenges in studying disease processes using observational cohort data
Authors: Cook Richard J. , Lawless Jerald F. 
Published: October 2024

Abstract
Cohort studies of disease processes deal with events and other outcomes that may occur in individuals following disease onset. The particular goals are often the evaluation of interventions and estimation of the effects of risk factors that may affect the disease course. Models and methods of event history analysis and longitudinal data analysis provide tools for understanding disease processes, but there are numerous challenges in practice. These are related to the complexity of the disease processes and to the difficulty of recruiting representative individuals and acquiring detailed longitudinal data on their disease course. Our objectives here are to describe some of these challenges and to review methods of addressing them. We emphasize the appeal of multistate models as a framework for understanding both disease processes and the processes governing recruitment of individuals for cohort studies and the collection of data. The use of other observational data sources in order to enhance model fitting and analysis is discussed.
Impact on physico-chemical characteristics of cream cheese analogue using blend of dairy and vegetable fat
Authors: Junaid Muhammad , Rehman Tasbeeha , Imran Muhammad , Inayat Saima , Rehman Hifz Ur , Ullah Ehsan , Muzamil Hafiz Shahzad , Younas Umair 
Published: October 2024

AbstractCream cheese analogue is a soft cheese with a slightly sweet and pleasantly tangy taste. It is prepared using the substitutes of dairy fats and proteins partially or completely. Cream cheese analogue ingredients are purchased carefully keeping in mind the required specifications. For the above-mentioned research, different samples of cream cheese (T0, T1, T2 and T3) were manufactured with standardized fat and protein and the moisture was maintained at 50–55% during these trials. All ingredients were added in a large container for mixing and cooking treatment for 1–2 min at 75 °C and homogenized for 5–6 min with the help of a hand mixture until completely homogenous sample was obtained. Samples were then transferred in to another container and allowed them to attain temperature between 20 and 25 °C. After that, samples were incubated with the addition of mesophilic culture until desired pH (4.6–4.7) was achieved. Later samples were heated at 50–55 °C for 2–3 min and then placed in a muslin cloth and left overnight for whey drainage. Physicochemical, microbial analysis were performed while sensory evaluation was performed using different parameters and scales. Sample prepared using 75% dairy cream and 25% cocoa butter substitute fat (T1) showed good results. T1 had better consistency which was considered desirable characteristics of cream cheese. This research proved the cost effective as cream cheese prepared with plant-based fat which made its production possible at industrial level. Cream cheese which was made from dairy fat (75%) and cocoa butter substitute fat (25%) had more springiness, smoothness, gumminess, more pleasant taste, color, flavor and aroma than other samples. This dairy product can be used in future in Pakistan.
Contribution of environmental and biological factors to bacterial community structure and stability in a subalpine lake
Authors: Guo Ping , Li Cui , Liu Jinxian , Wu Tiehang , Chai Baofeng 
Published: October 2024

Abstract
Bacterial community play an essential role in regulating water quality and the global biogeochemical cycle in aquatic ecosystems. However, how trophic interactions (i.e., biotic factors) regulate the diversity and composition of bacterial community in lake ecosystems remains unknown. Here, we employed DNA meta-barcoding of water samples to explore the impact of bacterivorous protozoans on the bacterial community. The results showed significant seasonal variations in the diversity and composition of both bacterial and protist communities. The composition of bacterivorous protozoans was identified as the primary predictor for the bacterial community alpha diversity in spring and summer, and for beta diversity in spring and autumn, indicating that biotic interactions play a greater role in driving the diversity of bacterial community across different seasons. Biological factors were more important than environmental factors for explaining the variations in the relative abundance of several bacterial genera (i.e., Pseudoxanthomonas, hgcI_clade, and Pseudorhodobacter). Network analyses showed that bacterial networks differed among seasons, and the autumn network exhibited the highest stability. Our findings indicated that the bacterial community stability was significantly affected by environmental factors, specifically SO4
2–and PO4
3–, rather than bacterivorous protozoans. Overall, our findings provide new perspectives on the role of trophic interactions in maintaining the structure of bacterial community in different seasons, and enhance our understanding of the bacterial community assembly in lake ecosystems.
Expert Consensus Recommendations on a Biosimilars Value Framework for the Gulf Cooperation Council Countries
Authors: Alnaqbi Khalid A. , Al-jedai Ahmed , Farghaly Mohamed , Omair Mohammed A. , Hamad Anas , Abutiban Fatemah M. A. , Shirawi Ali Al , Rayes Hanan Al , Aldallal Sarah , Fahmy Sahar , Simoens Steven 
Published: October 2024

Abstract
Objective
This paper aims to develop a biosimilar value framework with local stakeholders in Gulf Cooperation Council (GCC) countries.

Methods
A convenience sample of ten key opinion leaders from the United Arab Emirates, Kingdom of Saudi Arabia, Kuwait, Oman and Qatar participated in an expert panel meeting in November 2022 that examined factors positively influencing biosimilar adoption in these countries. The discussion was structured around a conceptual biosimilar value framework and an overview of biosimilar policies as derived from a targeted review of the peer-reviewed and grey literature.

Results
The expert panel agreed on a biosimilar value framework for the GCC countries that is founded on trust, cost savings and contextual considerations. They emphasized the importance of launching educational initiatives that build trust in and expand knowledge of all stakeholders about biosimilars. This also includes making stakeholders aware of the various value propositions of biosimilars as an instrument to produce, for example, cost savings. Finally, they stressed that biosimilar adoption is influenced by contextual factors such as incentives and implementation efforts.

Conclusion
Our proposed biosimilars value framekwork is the first set of recommendations in the Arab countries designed to help policymakers and decision-makers promote biosimilar adoption, both in high-income GCC countries and in low- and middle-income countries.
Regulatory mechanism of bamboo biochar dosage on cadmium accumulation in Salix psammophila: insights from rhizosphere microbial communities, assembly processes, and interactions
Authors: Gai Xu , Xing Wenli , Cheng Wanqing , Xiao Jiang , Chen Guangcai 
Published: October 2024

AbstractSoil amendments play a pivotal role in regulating rhizosphere microbial communities, which is essential for maintaining robust plant growth under adverse environmental conditions. However, the microbial mechanisms that underlie the impact of biochar on phytoremediation performance remain incompletely understood in the context of different application rates. Here, we compared the phytoremediation performance, rhizosphere microbial community characteristics, and microbial interactions in Salix psammophila across different biochar application rates (1%, 3%, 5%, and 7%) in Cd-contaminated soil. Applying 5% biochar increased plant biomass by 10.02%, root activity by 183.82%, and Cd accumulation by 13.65%. Lower biochar rates (1% and 3%) decreased Cd accumulation in plants by 21.89% and 42.05%, respectively, compared to the control. Rhizosphere soil properties and Cd content, except for nitrogen, showed a gradient change with increasing biochar application rates. This was accompanied by an elevation in the Chao1 index for the bacterial community, although the fungal community remained unaffected in terms of diversity and structure. Null-model analyses indicated that fungal community assembly was mainly driven by ecological drift, explaining its unresponsiveness to biochar application. Applying 1% biochar enhanced microbial network stability while reducing bacterial network complexity. Conversely, 3% biochar application resulted in the lowest microbial network stability. Biochar application, except 3%, reduced the proportion of bacteria-fungi associations, suggesting increased independence between two microbial kingdoms. Random forest and piecewise structural equation models revealed that phytoremediation performance is influenced by microbial network stability, complexity, and bacteria-fungi associations. Fungal complexity and stability, along with bacterial stability, were identified as key predictors of phytoremediation performance. Our findings reveal potential mechanisms by which biochar influences phytoremediation through altering microbial interactions. For long-term microbial stability and cost-effectiveness, a 1% biochar application is recommended for phytoremediation. Conversely, for rapid Cd accumulation in plants, a 5% biochar application is optimal.
Graphical Abstract
Socioeconomic status and sex ratio in the contemporary Hungarian population
Authors: Sarkadi Fanni , Szász Eszter , Rosivall Balázs 
Published: October 2024

Abstract
According to the Trivers–Willard hypothesis (TWH), when the mother's condition around conception influences the future reproductive success of male and female offspring differently, the adjustment of offspring sex ratio (SR) to maternal condition will increase the parents’ fitness. The TWH has been tested in several taxa, including humans where socioeconomic status as an index of condition has been widely used. The results are inconsistent, possibly because the preconditions of the TWH are not always met. To investigate the preconditions and prediction of the TWH in the contemporary Hungarian population, we collected data by an online questionnaire on self-perceived childhood living standard, the number of children and the sex of the respondents’ siblings. We found no sex-specific relationship between reproductive success and childhood living standards, thus the precondition of the TWH was not met. We found no relationship between socioeconomic status and offspring SR when data from the whole country was used, but there was a tendency in the predicted direction when we used data from Budapest and considered the SR of only those family members who were born under similar conditions. Similar approaches should be preferred in the future to avoid noise caused by changing status during the reproductive lifespan.
Performance of a large language model for identifying central line-associated bloodstream infections (CLABSI) using real clinical notes
Authors: Rodriguez-Nava Guillermo , Egoryan Goar , Goodman Katherine E. , Morgan Daniel J. , Salinas Jorge L. 
Published: October 2024

Abstract
We evaluated one of the first secure large language models approved for protected health information, for identifying central line-associated bloodstream infections (CLABSIs) using real clinical notes. Despite no pretraining, the model demonstrated rapid assessment and high sensitivity for CLABSI identification. Performance would improve with access to more patient data.
Gravity modelling of ice thickness and valley geometry on Taku Glacier (T'aak̲ú K̲wáan Sít'i), Alaska
Authors: Borthwick Louise , Muto Atsuhiro , Tinto Kirsty 
Published: October 2024

Abstract
Taku Glacier recently began retreating for the first time since the late 19th century but limited observations of its bed leaves uncertainties on how this retreat will proceed. In this study, we use ground-based gravity measurements to improve the extent of bed-elevation estimates on the Taku by modelling the glacier in 3D. We find the across-flow geometry of the middle to upper reach of the Taku and the Matthes branch has a step-like feature near the edge and a wide, flat bottom. We constrain the ice thickness along flow within uncertainty limits and provide a range of expected values. Along the centre line of our model, we find a maximum ice thickness of 1556 ± 143 m and the deepest bed at 445 ± 166 m below sea level. The along-flow results also delineate two bedrock bumps, which could help stabilise the retreat of the Taku when its terminus is submerged in water. We model the bed to be below sea level until at least 35 km upstream of the terminus where the Matthes branch joins the main branch, improving constraints on how far upstream the Taku would be vulnerable to marine retreat.
Work after lawful status: formerly undocumented immigrants’ gendered relational legal consciousness and workplace claims-making
Authors: Tenorio Luis Edward 
Published: October 2024

AbstractUndocumented status impedes immigrants’ workplace claims to legal rights and better treatment. But what happens when they obtain lawful permanent residency – does the reluctance to make claims in the workplace change? If so, how? Drawing on timeline interviews, I examine changes in the relational legal consciousness and reported workplace claims-making of 98 formerly undocumented Latino immigrants. Most respondents reported increased willingness to engage in, and follow through with, workplace claims. However, gendered differences emerged. Men’s claims largely revolved around wage negotiations, moving to a better paying position, and enforcement of legal rights with an attached monetary value. They were also more likely to frame claims as legal rights. In contrast, women’s claims largely revolved around better work treatment, access to job benefits, and workplace accommodations. They were also more likely to frame claims as moral rights. I explain these outcomes as a function of three relational mechanisms: lawful status being understood relative to experiences being undocumented; gendering in the legalization process; and social ties promoting gendered expectations of lawful permanent residency. My findings highlight the importance of gendered differences in relational legal consciousness and how lived reference points (e.g., prior undocumented experience) inform how legal consciousness changes over time.