bluuebunny/crossref_metadata_2025_split huggingface dataset:
Recreational sector is the dominant source of fishing mortality for oceanic fishes in the Southeast United States Atlantic Ocean
Authors: Shertzer Kyle W. , Williams Erik H. , Craig Joseph Kevin , Fitzpatrick Eric E. , Klibansky Nikolai , Siegfried Katie I. 
Published: July 2019

AbstractRecreational fishing is increasingly recognised as an important source of mortality for marine fish populations. In the United States, estimates of marine recreational catch and effort were recently revised for the time period 1981 and beyond, and for many species, the revised estimates were substantially higher than the original values. Here, the proportion of total landings that came from the recreational sector in the Southeast US Atlantic was quantified. The proportions for 22 oceanic species and for all species combined were computed, using a full time series of landings (1981–2016) and a more recent time series (1999–2016). For the full and recent time series, landings of most species (15/22 and 17/22, respectively) were dominated by the recreational sector. For all species combined, 71% of landings in the full time series were from the recreational sector, and 76% in the recent time series. Trend analysis indicated that most species had a stable or increasing proportion of landings from the recreational sector. In addition, stock assessments were conducted on four species, and the catch revisions increased the estimated scale of abundance and, in some cases, affected stock or fishery status. This work underscores the importance of recreational fishing for marine resource management.
A genome‐wide search for local adaptation in a terrestrial‐breeding frog reveals vulnerability to climate change
Authors: Cummins Deanne , Kennington W. Jason , Rudin‐Bitterli Tabitha , Mitchell Nicola J. 
Published: July 2019

AbstractTerrestrial‐breeding amphibians are likely to be vulnerable to warming and drying climates, as their embryos require consistent moisture for successful development. Adaptation to environmental change will depend on sufficient genetic variation existing within or between connected populations. Here, we use Single Nucleotide Polymorphism (SNP) data to investigate genome‐wide patterns in genetic diversity, gene flow and local adaptation in a terrestrial‐breeding frog (Pseudophryne guentheri) subject to a rapidly drying climate and recent habitat fragmentation. The species was sampled across 12 central and range‐edge populations (192 samples), and strong genetic structure was apparent, as were high inbreeding coefficients. Populations showed differences in genetic diversity, and one population lost significant genetic diversity in a decade. More than 500 SNP loci were putatively under directional selection, and 413 of these loci were correlated with environmental variables such as temperature, rainfall, evaporation and soil moisture. One locus showed homology to a gene involved in the activation of maturation in Xenopus oocytes, which may facilitate rapid development of embryos in drier climates. The low genetic diversity, strong population structuring and presence of local adaptation revealed in this study shows why management strategies such as targeted gene flow may be necessary to assist isolated populations to adapt to future climates.
Transnational grandparenting: an introduction
Authors: NEDELCU MIHAELA , WYSS MALIKA 
Published: July 2019

AbstractThis first special issue dedicated to grandparenting patterns and their significance within transnational families sheds new light on transnational grandparenting as a phenomenon reflecting the convergence of three major transformations in today's societies – global ageing, diversification of migration and mobility flows, and lifestyle individualization. It contains five articles based on empirical studies conducted in several European countries (Switzerland, Luxembourg, Spain, Romania, and the Czech Republic) focusing on transnational families from both EU and non‐EU countries (Germany, France, Italy, Brazil, Morocco, Algeria, Switzerland, Britain, Portugal, Romania, and Vietnam). These articles portray transnational grandparenting through the prism of three nexuses (mobile/non‐mobile, migrant/non‐migrant, and kin/non‐kin), thus allowing one to understand grandparents' roles in the transnational circulation of care in the light of contemporary family transformations on the one hand, and of the increased transnationalization of everyday ‘doing family’ practices on the other.
Spatial–temporal evolution of the port–hinterland relationship: A case study of the Midstream Yangtze River, China
Authors: He Dan , Sun Zhijing , Gao Peng , Lau Yui‐yip 
Published: July 2019

AbstractMost scientific attention on port studies centers on deep sea ports, especially container ports. In this paper, in contrast, attention is focused on the spatial–temporal development of inland waterway ports on the Midstream Yangtze River from 2001 to 2013. The aim of this study is to assess two relevant and complementary questions of the hinterland evolution: its geographical extent and the coordination relationship with the inland port. To conduct the study, it was necessary to first identify the boundaries of the ports' hinterlands within the given timeframe. Then, the coupling coordination degree model was introduced to explore the underlying relationship between the port service and hinterland economy. Furthermore, to better depict the intricate economic characteristics of the hinterland, the development stage theory was applied in the models. The results highlight the emergence of a discontinuous hinterland at Wuhan Port and its reinforcement of primacy with respect to fierce hinterland rivalry. It also demonstrates that an interplay between major ports and their corresponding hinterlands evolves from the transitional stage, characterized by lagging port service, to the multi‐stage, wherein the supply of ports partly outstrips hinterland demand.
Clinical efficacy of a new cetylpyridinium chloride‐hyaluronic acid–based mouthrinse compared to chlorhexidine and placebo mouthrinses—A 21‐day randomized clinical trial
Authors: Tadakamadla Santosh Kumar , Bharathwaj Venkata V. , Duraiswamy Prabu , Sforza Chiarella , Tartaglia Gianluca M. 
Published: July 2019

AbstractObjectiveTo compare the effectiveness of a novel cetylpyridinium chloride (CPC)‐hyaluronic acid (HA)–based mouthrinse with chlorhexidine (CHX) and placebo mouthrinses in preventing plaque and gingivitis. The secondary outcomes were calculus, extrinsic stains, oral malodour and occurrence of adverse events.MethodsA 21‐day randomized, double‐blind, three‐arm parallel study with random allocation of young dental students to any of the three mouthrinse groups. Thorough prophylaxis was done at baseline followed by a baseline examination for oral malodour, extrinsic stains, calculus, gingivitis and plaque by a single examiner. All the subjects used the allocated mouthrinse twice daily for 21 days and were examined again at the end of the experimental period. They were also interviewed for adverse events. Change in the scores of clinical indices was calculated and compared between the groups.ResultsA total of 75 subjects were included and completed the experiment. There was a significant difference for change in plaque index scores between the groups (P = .015); subjects in the placebo group experienced higher levels of plaque accumulation than the other groups. Teeth staining increased in the CHX (P < .001) and placebo groups (P = .002), but not in CPC‐HA users (P = .573). No significant differences were found between the three experimental groups for change in the gingival index (P = .08), calculus scores (P = .494), oral malodour (P = .870) and reporting of adverse events (P = .249).ConclusionsCPC‐HA and CHX had similar effectiveness in preventing plaque accumulation, while no differences were observed between the mouthrinses for preventing gingivitis. Dental staining was caused by CHX and the placebo mouthrinses but not by CPC‐HA mouthrinse.
Potentially bioaccessible phenolics, antioxidant capacities and the colour of carrot, pumpkin and apple powders – effect of drying temperature and sample structure
Authors: Bochnak Justyna , Świeca Michał 
Published: July 2019

AbstractThe study aimed to examine carrot, pumpkin and apple powders produced by hot‐air‐drying (50, 60, 70 °C) of samples with different levels of fragmentation (cut, grated, blended). The drying temperatures and sample structure were shown to be important determinants of the quality of the powders. The best colour stability of carrot, pumpkin and apple was found for the grated sample dried at 70 °C, the blended sample dried at 70 °C and the blended sample dried at 70 °C, respectively. The highest antiradical capacity and reducing power were found for powders obtained after drying the cut samples at 70 °C. Total phenolics and free radical quenchers were well bioaccessible in vitro. In turn, the reducing power was markedly reduced after drying at 50 °C. The analysed powders are a valuable source of concentrated bioactive ingredients, which predisposes them to serve as functional food components.
Responses to bullying among individuals with intellectual and developmental disabilities: Support needs and self‐determination
Authors: Griffin Megan M. , Fisher Marisa H. , Lane Laurel A. , Morin Lindsay 
Published: July 2019

AbstractBackgroundCompared to the general population, individuals with intellectual and developmental disabilities (IDD) more often experience bullying and its negative social and emotional impacts. Prior studies explored bullying of individuals with IDD primarily through investigations of the perspectives of others and the negative impacts of bullying. The current study examined how individuals with IDD describe their responses to experiences of bullying, with a focus on whether responses included component skills of self‐determination.MethodEighteen adults with IDD (50% female) aged 18–63 years were interviewed about their experiences with bullying. Interviews were analysed to determine responses to bullying and the degree to which their responses demonstrated self‐determination.ResultsData analysis revealed two primary themes, outside support and self‐determination, with additional subthemes.ConclusionsFindings provide a more nuanced description of the ways in which individuals with IDD respond to bullying, including the demonstration of self‐determination skills. Implications for research and practice are discussed.
Motivational and cognitive benefits of training in immersive virtual reality based on multiple assessments
Authors: Makransky Guido , Borre‐Gude Stefan , Mayer Richard E. 
Published: July 2019

AbstractThe main objective of this study was to examine the effectiveness of immersive virtual reality (VR) as a medium for delivering laboratory safety training. We specifically compare an immersive VR simulation, a desktop VR simulation, and a conventional safety manual. The sample included 105 first year undergraduate engineering students (56 females). We include five types of learning outcomes including post‐test enjoyment ratings; pre‐ to post‐test changes in intrinsic motivation and self‐efficacy; a post‐test multiple choice retention test; and two behavioral transfer tests. Results indicated that the groups did not differ on the immediate retention test, suggesting that all three media were equivalent in conveying the basic knowledge. However, significant differences were observed favoring the immersive VR group compared to the text group on the two transfer tests involving the solving problems in a physical lab setting (d = 0.54, d = 0.57), as well as enjoyment (d = 1.44) and increases in intrinsic motivation (d = 0.69) and self‐efficacy (d = 0.60). The desktop VR group scored significantly higher than the text group on one transfer test (d = 0.63) but not the other (d= 0.11), as well as enjoyment (d =1.11) and intrinsic motivation (d =0.83).
Long non‐coding RNA LINC01535 promotes cervical cancer progression via targeting the miR‐214/EZH2 feedback loop
Authors: Song Hongjuan , Liu Yuan , Jin Xin , Liu Yang , Yang Yanling , Li Lei , Wang Xuan , Li Guilin 
Published: July 2019

AbstractLong non‐coding RNAs (lncRNAs) have shown critical roles in multiple cancers via competitively binding common microRNAs. miR‐214 has been proved to play tumour suppressive roles in various cancers, including cervical cancer. In this study, we identified that lncRNA LINC01535 physically binds miR‐214, relieves the repressive roles of miR‐214 on its target EZH2, and therefore up‐regulates EZH2 protein expression. Intriguingly, we also found that EZH2 directly represses the expression of miR‐214. Thus, miR‐214 and EZH2 form double negative regulatory loop. Through up‐regulating EZH2, LINC01535 further represses miR‐214 expression. Functional experiments showed that enhanced expression of LINC01535 promotes cervical cancer cell growth, migration and invasion in vitro and cervical cancer xenograft growth in vivo. Reciprocally, LINC01535 knockdown suppresses cervical cancer cell growth, migration and invasion. Activation of the miR‐214/EZH2 regulatory loop by overexpression of miR‐214 or silencing of EZH2 reverses the roles of LINC01535 in promoting cervical canc`er cell growth, migration and invasion in vitro and cervical cancer xenograft growth in vivo. Clinically, LINC01535 is significantly up‐regulated in cervical cancer tissues and correlated with advanced clinical stage and poor prognosis. Moreover, the expression of LINC01535 is reversely associated with the expression of miR‐214 and positively associated with the expression of EZH2 in cervical cancer tissues. In conclusion, this study reveals that LINC01535 promotes cervical cancer progression via repressing the miR‐214/EZH2 regulatory loop.
miR‐516a‐3p inhibits breast cancer cell growth and EMT by blocking the Pygo2/Wnt signalling pathway
Authors: Chi Yanyan , Wang Feng , Zhang Tengfei , Xu Han , Zhang Yana , Shan Zhengzheng , Wu Shaoxuan , Fan Qingxia , Sun Yan 
Published: July 2019

AbstractmiR‐516a‐3p has been reported to play a suppressive role in several types of human tumours. However, the expression level, biological function and fundamental mechanisms of miR‐516a‐3p in breast cancer remain unclear. In the present study, we found that miR‐516a‐3p expression was down‐regulated and Pygopus2 (Pygo2) expression was up‐regulated in human breast cancer tissues and cells. Through analysing the clinicopathological characteristics, we demonstrated that low miR‐516a‐3p expression or positive Pygo2 expression was a predictor of poor prognosis for patients with breast cancer. The results of a dual luciferase reporter assay and Western blot analysis indicated that Pygo2 was a target gene of miR‐516a‐3p. Moreover, overexpression of miR‐516a‐3p inhibited cell growth, migration and invasion as well as epithelial‐mesenchymal transition (EMT) of breast cancer cells, whereas reduced miR‐516a‐3p expression promoted breast cancer cell growth, migration, invasion and EMT. Furthermore, we showed that miR‐516a‐3p suppressed cell proliferation, metastasis and EMT of breast cancer cells by inhibiting Pygo2 expression. We confirmed that miR‐516a‐3p exerted an anti‐tumour effect by inhibiting the activation of the Wnt/β‐catenin pathway. Finally, xenograft tumour models were used to show that miR‐516a‐3p inhibited breast cancer cell growth and EMT via suppressing the Pygo2/Wnt signalling pathway. Taken together, these results show that miR‐516a‐3p inhibits breast cancer cell growth, metastasis and EMT by blocking the Pygo2/ Wnt/β‐catenin pathway.
Potential competition and quality disclosure
Authors: Oh Frederick Dongchuhl , Park Junghum 
Published: July 2019

AbstractThis study presents a model of quality disclosure in which an incumbent, through its quality and disclosure choices, influences the potential that a new entrant enters the market. In this regard, we consider a sequential framework in which the incumbent chooses its quality and decides whether to disclose it to the market; subsequently, the entrant makes the same decisions, if it enters the market. We show that the potential competition can create strategic incentives for the incumbent to choose nondisclosure, because the availability of information about the incumbent's quality promotes entry by enhancing the entrant's expected profit from the market. In addition, an analysis of the effects of mandatory disclosure laws suggests that they can be effective in encouraging new market entrants and in improving the product quality of established firms.
Aspirin up‐regulates suppressor of cytokine signaling 3 in glial cells via PPARα
Authors: Chakrabarti Sudipta , Roy Avik , Prorok Tim , Patel Dhruv , Dasarathi Sridevi , Pahan Kalipada 
Published: July 2019

AbstractNeuroinflammation is being recognized as a hallmark of different neurodegenerative disorders, including Alzheimer’s disease. Suppressor of cytokine signaling 3 (SOCS3) is an anti‐inflammatory molecule, which is known to inhibit cytokine signaling and inflammatory gene expression in different cells. However, the pathways by which SOCS3 could be up‐regulated in brain cells are poorly understood. Aspirin is a widely available pain reliever that is showing promise beyond its known pain‐relieving capacity. This study underlines the importance of aspirin in upregulating SOCS3 in astrocytes and microglia. Aspirin increased the expression of Socs3 mRNA and protein in mouse astrocytes and BV‐2 microglial cells in both a time‐ and dose‐dependent manner. While investigating the mechanism, we found that Socs3 gene promoter harbors peroxisome proliferator response element and that aspirin up‐regulated SOCS3 in astrocytes isolated from PPARβ (−/−), but not PPARα (−/−), mice. Accordingly, aspirin increased SOCS3 in vivo in the cortex of wild type and PPARβ (−/−), but not PPARα (−/−), mice. Similarly, aspirin treatment increased astroglial and microglial SOCS3 in the cortex of FAD5X, but not FAD5X/PPARα (−/−), mice. Finally, recruitment of PPARα by aspirin to the proximal, but not distal, peroxisome proliferator response element of the Socs3 promoter suggests that aspirin increases the transcription of Socs3 gene via PPARα. This study describes a novel property of aspirin in elevating SOCS3 in glial cells via PPARα and suggests that aspirin may be further considered for therapeutic application in neuroinflammatory and neurodegenerative disorders.
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Temporospatial effects of acyl‐ghrelin on activation of astrocytes after ischaemic brain injury
Authors: Dong Ruirui , Chen Man , Liu Jing , Kang Jihong , Zhu Shigong 
Published: July 2019

AbstractThe protective mechanisms of astrocyte signalling are based on the release of neurotrophic factors and the clearing of toxic substances in the early stages of cerebral ischaemia. However, astrocytes are also responsible for the detrimental effects that occur during the later stages of ischaemia, in which glial scars are formed, thereby impeding neural recovery. Acyl‐ghrelin has been found to be neuroprotective after stroke, although the influence of acyl‐ghrelin on astrocytes after ischaemic injury is yet to be clarified. In the present study, we used permanent middle cerebral arterial occlusion to establish a brain ischaemia model in vivo, as well as oxygen and glucose deprivation (OGD) to mimic ischaemic insults in vitro. We found that acyl‐ghrelin injection significantly increased the number of activated astrocytes in the peri‐infarct area at day 3 after brain ischaemia and decreased the number of activated astrocytes after day 9. Moreover, the expression of fibroblast growth factor 2 (FGF2) in the ischaemic hemisphere increased markedly after day 3, and i.c.v. injection of SU5402, an inhibitor of FGF2 signalling, abolished the suppression effects of acyl‐ghrelin on astrocyte activation in the peri‐infarct region during the later stages of ischaemia. The results from in vitro studies also showed the dual effect of acyl‐ghrelin on astrocyte viability. Acyl‐ghrelin increased the viability of uninjured astrocytes in an indirect way by stimulating the secretion from OGD‐injured astrocytes. It also inhibited the astrocyte viability in the presence of FGF2 in a dose‐dependent manner. Furthermore, the expression of acyl‐ghrelin receptors on astrocytes was increased after acyl‐ghrelin and FGF2 co‐treatment. In conclusion, acyl‐ghrelin promoted astrocyte activation in the early stages of ischaemia but suppressed the activation in later stages of ischaemic injury. These later effects were likely to be triggered by the increased expression of endogenous FGF2 after brain ischaemia.
Nursing Research Literature Production in Terms of the Scope of Country and Health Determinants: A Bibliometric Study
Authors: Kokol Peter , Železnik Danica , Završnik Jernej , Blažun Vošner Helena 
Published: July 2019

AbstractPurposeThe aim of this paper was to present the results of the first study in which nursing research literature production was studied in the relation to country and health determinants.DesignBibliometric analysis was used.MethodsThe corpus of nursing publications was harvested from the Scopus indexing and abstracting database. Using research articles' metadata (funding acknowledgments, publication years, and author affiliations), we analyzed global trends in the nursing research literature production of funded and nonfunded publications. Next, we performed a regression analysis and correlation analysis relating nursing research productivity to health and country determinants.FindingsThe search resulted in 118,870 papers, among which 22.0% were funded (24.7% for G8 countries). Nursing literature production is exhibiting a positive trend. The United States is by far the most productive country in terms of funded and nonfunded literature production, although it is ranked only ninth in per capita production, for which Sweden is the most productive country regarding funded papers. The study also revealed that gross domestic product, human development factor, and gross national income were related to nursing research literature productivity.ConclusionsThe positive trend in nursing research literature production (both funded and nonfunded) reveals a growth in nursing research funding. Regionally centered research literature production shows that the more developed and “rich” countries produce the majority of publications. A positive correlation is evident between country determinants and research literature production, as is a positive correlation between per capita literature research production and well‐being and health determinants.Clinical RelevanceSubstantial growth in terms of nursing research literature production and research funding has been identified. While a limited amount of research in this area exists, this study revealed some interesting relations between nursing literature production and country and health determinants, which might motivate nursing researchers to pursue more intensive research and funders to support further growth of nursing research funding.