bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prevalence of organic central precocious puberty in males: criteria for a high index of suspicion
Authors: Amodeo Maria Elisa , Deodati Annalisa , Pedicelli Stefania , Mirra Giulia , Pampanini Valentina , Cianfarani Stefano 
Published: November 2024

Graphical abstractAbstractBackgroundA high prevalence (40–75%) of organic brain lesions in boys with central precocious puberty (CPP) has been reported.ObjectivesTo evaluate the causes of CPP in a large cohort of males and to identify the possible predictive factors for organic brain lesions in males.DesignAn observational study was conducted in 102 otherwise healthy boys with CPP diagnosed from 1998 to 2023 in a single tertiary center.MethodsAll boys underwent a thorough clinical, endocrine and neuroimaging assessment with a detailed evaluation of the pituitary region.ResultsOrganic CPP was found in only 8/102 children (7.8%). Children with brain tumors were younger than 8 years, had no family history positive for precocious puberty and maternal menarche occurred at an age significantly more advanced than in children with idiopathic CPP. Headache was reported at diagnosis in 7/8 children with brain tumors. A progressive increase in the occurrence of idiopathic CPP in males has been observed in the last two decades with a peak of new diagnoses during the pandemic lockdown.ConclusionsOur findings indicate that the prevalence of pathological brain lesions in boys with CPP is considerably lower than previously reported, thus making the diagnosis less alarming. Age younger than 8 years, presence of neurological symptoms, family history negative for precocious puberty in the first-degree relatives and age of maternal menarche older than 11 years raise suspicion of organic CPP and should lead to prompt neuroimaging.Significance statementDifferently from what has been reported in most previous studies, our study has shown a low incidence of brain tumors in male children with precocious puberty, thus making the diagnosis less alarming for parents and physicians. Some criteria for a high index of suspicion of brain tumors in boys with precocious puberty have been identified. Finally, a progressive increase in the occurrence of idiopathic CPP in boys has been observed over the past two decades with a peak of new diagnoses during the pandemic lockdown, as previously reported in girls.
A NEUROCIÊNCIA E AS METODOLOGIAS DINÂMICAS PARA ALUNOS COM DEFICIT COGNITIVO
Authors: Costa Poliana Silva , Pereira Wagner Ferreira , Nascimento José Wilton Serrão , Silva Isabela Lobato Guedelha da , Cunha Daiana  Cássia do Carmo , Xavier Maria Cristina Rodrigues Silva , Negrão Cleonice Rodrigues , Costa José Francisco da Silva 
Published: November 2024

Este artigo objetiva compreender a aplicação dos conhecimentos da neurociência no processo de ensino e aprendizagem voltados para alunos que possuem déficit cognitivo considerando abordagem teórica para aplicar nas práticas pedagógicas com intuito de melhorar o desenvolvimento cognitivo, superando as dificuldades a partir de metodologias dinâmicas, jogos e ludicidade. Justifica-se a pesquisa considerando que a neurociência representa uma área capaz de auxiliar os alunos que possuem déficit cognitivo. As atividades metodológicas colaboraram para favorecer a plasticidade cerebral, promovendo um aprendizado significativo levando em conta as limitações e potencialidades dos alunos, A metodologia aplicada busca adotar uma abordagem qualitativa e bibliográfica com pesquisas em artigos, livros, teses e dissertações relacionados a teoria neurocientíficos e educacionais. Os resultados indicaram que atividades que estimulam simultaneamente múltiplas áreas cerebrais por meio de exercícios que combinam música, movimento e arte além de outras metodologias, são significativas para desenvolver habilidades cognitivas em alunos com déficit cognitivos, além disso, a neurociência aponta segundo estudos na área que o uso de metodologias como aplicação de jogos educativos é capaz de favorecer a aprendizagem incluindo ainda atividades que envolvem coordenação motora e concentração no processo educativo, pode fortalecer a neuroplasticidade, resultando em maior progresso no aprendizado. Atividade metodológica é capaz de criar estratégias pedagógicas de acordo com perfil neurológico de cada aluno, pois a integração de conhecimentos da neurociência com práticas pedagógicas, auxilia quando aplicada numa abordagem mais eficaz e ainda atividades lúdicas e interativas que podem ativar os estímulos variados, tornando-se fundamentais para desenvolver habilidades cognitivas, reduzindo as dificuldades de aprendizagem. Conclui-se que o treinamento contínuo, em um ambiente acolhedor e adaptado, pode promover a plasticidade cerebral na melhoria do desempenho do déficit cognitivo. Portanto, a formação continuada em neurociência pode auxiliar para inovação metodológica, sendo aplicada à educação, a fim de desenvolver práticas cada vez mais inclusivas e eficientes.
A Qualitative Approach to Cancer Awareness Among Rural Women
Authors: Neha PG Nadupuru , Sanjeeva Rao Nallapu Samson 
Published: November 2024

Introduction: The incidence of various types of cancers in India are set to increase thereby putting an increased burden on the health system. There is a need for people to know sufficiently about cancer, the various types, the risk factors, the early symptoms and signs etc. so that they can come for professional diagnosis early. However, the fear of cancer prevents screening, early diagnosis and prompt treatment.
Methodology: A qualitative study was done about cancer awareness among women in the rural areas using qualitative methods like Focus Group Discussions (FGD), In Depth interviews and Key Informant interviews.
Results: Incurability of cancer, stigma, fear of cancer, need for support – physical, emotional & spiritual, lack of discussion in the community, causes of cancer, knowledge about cancer and personal experience with cancer are the themes identified in this study.
Discussion: Stigma concerning cancer is a challenge to cancer awareness and control activities in any society. “Cancer fear” is any fear, anxiety, or worry related to cancer, including causes or consequences of cancer such as fear of treatment for cancer. Social support is necessary for physical adaptation, wellbeing and emotional adjustment in people suffering with cancer.
Conclusion: This study reveals that knowledge about cancer in rural women is low and there are many misconceptions. There is reluctance to discuss about it due to fear and stigma.
Recommendations: Following appropriate cancer education programmes with a stress on rural populations, prevention and screening programmes must be taken up urgently. Healthcare workers and volunteers in rural health care must be given necessary training to be able to give adequate cancer awareness, addressing key misconceptions.
Chosen Aspects of Psychiatric Confidentiality in the Jurisprudence of the Supreme Court
Authors: Górski Paweł 
Published: November 2024

Psychiatric secrecy, which is based on Article 50 of the Law of August 19, 1994 on Mental Health Protection, is intended to protect the dignity and privacy of patients and their families. However, it does not have an absolute character and can be limited or abrogated in certain situations, examples of which can be found in case law. Accordingly, the purpose of the article was to analyze the Supreme Court’s rulings on mental health issues and the protection of secrecy related to it.The article is an overview, analyzing the case law of the Supreme Court on the issue of psychiatric secrecy.The results of the analysis show that in the jurisprudence of the Supreme Court, the issue of psychiatric secrecy appears in the context of criminal proceedings, especially in cases related to the work of expert witnesses. The Court emphasizes that this secrecy is not absolute and may be subject to restrictions to protect other constitutional goods, but in proportion between the purpose of the restriction and the scope of the information disclosed. The Court’s rulings also emphasize the autonomy of psychiatric experts and the need to trust their professional competence, noting various aspects related to the evaluation of their work.Based on the analysis of the Supreme Court’s jurisprudence, it can be concluded that psychiatric confidentiality does not have an absolute character and can be limited in certain situations, but always with respect for the patient’s personal rights. The case law further indicates the need to balance this secrecy with other values, such as the welfare of the patient or society. It should also be noted that existing differences in the interpretation of the rules on the appointment of psychiatric experts in the criminal process may affect judicial practice in this area.
PENDAMPINGAN CUSTOMER RELATIONSHIP MANAGEMENT UMKM BATIK DI KABUPATEN JOMBANG GUNA MENCAPAI KEUNGGULAN BERSAING BERKELANJUTAN
Authors: Wibowo Nugroho Mardi , Widiastuti Yuyun , Saibudin Siti Ulandari 
Published: November 2024

The partner in this community service activity is UD Batik Tulis New Colet located in Jatipelem Village, Diwek District, Jombang Regency, East Java. The main problems faced by the partner: First, the decline in sales turnover. Second, customer loyalty has decreased, this is indicated by some customers no longer making batik purchase transactions to partners. The purpose of this community service: First increase the turnover of partners who have decreased. The second is to restore and increase customer loyalty that had experienced a decline in loyalty by marking that several market regions had not made purchase transactions to the partner. The method of implementing this community service program uses CRM assistance, stimulation, brainstorming and discussion, as well as monitoring & evaluation. The results of this service program: First, sales turnover increased by 52.57%. Second, the increase in customer loyalty is characterized by the addition of a market that actively transacts purchases, namely returning two old market regions to active customers transacting repurchase transactions and the addition of one new market region that actively transacts purchases. This community service activity impacts the economic empowerment of partners by improving marketing performance and competitive advantage of the partner on an ongoing basis.abtract in bahasaMitra dalam kegiatan pengabdian kepada masyarakat ini adalah UD Batik Tulis New berlokasi di Desa Jatipelem Kecamatan Diwek Kabupaten Jombang, Jawa Timur. Permasalahan utama yang dihadapi oleh mitra: Pertama, menurunnya omzet penjualan. Kedua, loyalitas pelanggan mengalami penurunan, hal ini ditandai dengan beberapa pelanggan sudah tidak lagi melakukan transaksi pembelian batik ke mitra. Tujuan pengabdian kepada masyarakat ini: Pertama meningkatkan omset mitra yang mengalami penurunan. Kedua mengembalikan dan meningkatkan loyalitas pelanggan yang sempat mengalami penurunan loyalitas dengan ditandainya beberapa wilayah pasar sudah tidak melakukan transaksi pembelian ke UD Batik Tulis New Colet. Metode pelaksanaan program pengabdian masyarakat ini menggunakan pendampingan customer relationship management (CRM), sumulasi, brainstorming dan diskusi, serta monitoring & evaluasi. Hasil dari program pengabdian ini: Pertama meningkatnya omzet penjualan sebesar 52,57%. Kedua, adanya peningkatan loyalitas pelanggan ditandai dengan penambahan pasar yang aktif bertransaksi pembelian yaitu mengembalikan dua wilayah pasar lama menjadi pelanggan aktif bertransaksi pembelian Kembali dan penambahan satu wilayah pasar baru yang aktif bertransaksi pembelian. Kegiatan pengabdian kepada masyarakat ini memiliki dampak terhadap keberdayaan mitra secara ekonomi berupa peningkatan kinerja pemasaran dan keunggulan bersaing UD Batik Tulis New Colet secara berkelanjutan.
PPM PENGEMBANGAN WISATA DESA DI DESA SUMBERMULYO KECAMATAN JOGOROTO KABUPATEN JOMBANG
Authors: Dwiningwarni Sayekti Suindyah , Chamariyah Chamariyah , Endah M Yurila , Ningsih Sumita Widiyah , Nur Fauziyah Ananda Istiqomah , Dwi Andari Syamsiyah Yuli 
Published: November 2024

Sumber Mulyo is a village located in Jogoroto Jombang District. Sumber Mulyo Village has potential in the field of village tourism because this village is location in an area that has a history of "PECEL" culinary tourism in Jombang Regency since the 1980s. The village tourism potential in this village has not been manage properly. The Community Service Program partner is BUMDes "Murni Jaya", which manages various business units, one of which is the fishing pond business unit. During the Covid-19 pandemic, this tour was in great demand by the people in the village, even people other the village.The objectives of this program are first, to improve the managerial capabilities of Partners in managing village tourism business units; second, to improve Partners' abilities and skills in keeping financial records. The methods used are training, mentoring, and monitoring. The results of this community service program include: first, Partners have a village tourism business plan; both Partners increased their ability to plan village tourism development; third, Partners increase their ability and skills in preparing financial reports.abstract in bahasaSumber Mulyo merupakan sebuah desa yang berada di Kecamatan Jogoroto Jombang. Desa Sumber Mulyo memiliki potensi di bidang wisata desa, karena desa ini terletak di daerah yang memiliki sejarah wisata kuliner”PECEL” di Kabupaten Jombang sejak tahun 1980 an. Potensi wisata desa yang terdapat di desa ini belum terkelola dengan baik. Mitra Program Pengabdian Masyarakat ini adalah BUMDes “Murni Jaya”, yang mengelola berbagai unit usaha, salah satunya adalah unit usaha wisata kolam pancing. Selama masa pandemi Covid-19, wisata ini sangat diminati oleh masyarakat di desa tersebut, bahkan masyarakat di luar desa tersebut.Tujuan program ini adalah pertama, untuk meningkatkan kemampuan managerial Mitra dalam mengelola unit usaha wisata desa; kedua, meningkatkan kemampuan dan ketrampilan Mitra dalam melakukan pencatatan keuangan. Metode yang digunakan adalah pelatihan, pendampingan dan monitoring. Hasil program pengabdian kepada masyarakat ini antara lain: pertama, Mitra memiliki perencanaan usaha wisata desa; kedua Mitra meningkat kemampuannya dalam membuat perencanaan pengembangan wisata desa; ketiga, Mitra meningkat kemampuan dan ketrampilannya dalam menyusun laporan keuangan.
PELATIHAN TIM PELACAK DAN KADER PEMANTAU DETEKTIF COVID-19 (DITEKSI AKTIF CORONA VIRUS DISEASE) DI DESA MARGAMUKTI, SUMEDANG
Authors: Ridwan Heri , Aisyah Iis , Astuti Ayu Prameswari Kusuma , Latifah Siti Lika 
Published: November 2024

Covid-19 terus mengalami mutasi dan menghasilkan varian-varian baru, termasuk BF.7 dan XBB.1.5, yang merupakan subvarian dari Omicron. Organisasi Kesehatan Dunia (WHO) telah mengidentifikasi varian XBB 1.5 sebagai yang paling menular. Oleh karena itu, diperlukan kontribusi dari anggota kader kesehatan untuk membantu dalam pemantauan dan deteksi awal individu yang dicurigai terinfeksi virus Covid-19. Kader kesehatan masyarakat adalah individu yang dipilih oleh masyarakat dan dilatih untuk menangani berbagai masalah kesehatan, baik pada tingkat individu maupun masyarakat, serta bekerja dekat dengan fasilitas pelayanan kesehatan. Tujuan dari program pengabdian kepada masyarakat ini adalah untuk menciptakan kader kesehatan yang memiliki peran sebagai detektif aktif Covid-19. Metode yang telah digunakan yaitu melalui pendidikan, pelatihan, diskusi, dan penilaian terkait dengan deteksi aktif Covid-19 bagi anggota kader. Hasil dari program ini adalah telah terbentuknya 18 kader detektif yang mampu melacak dan memonitor individu yang dicurigai terinfeksi Covid-19 di desa Margamukti. Rencana tindak lanjut kedepannya, tim Program Kesehatan Masyarakat (PkM) akan bekerjasama dengan pemerintahan desa-desa lain yang berada di wilayah kerja Puskesmas yang sama untuk menyelenggarakan pelatihan yang serupa kepada para kader kesehatan. Ini merupakan upaya kolaboratif dan partisipatif dalam meningkatkan kualifikasi para kader untuk kepentingan kesehatan masyarakat.
Achievement of Control of Severe Bronchial Asthma When Using Dupilumab
Authors: Kazmerchuk O. V. , Sobko E. A. , Demko I. V. 
Published: November 2024

The aim of the study was to evaluate the possibility of achieving control of severe bronchial asthma (BA) using genetically engineered biological therapy with Dupilumab. Materials and methods. The study included 32 patients with severe bronchial asthma (8 (25 %) men, mean age 58 [28; 65]) years, 24 (75 %) women, mean age 50 [26; 62] years) who received additional therapy with Dupilumab for 12 months. The endpoint of the study was 12 months of therapy with Dupilumab. The allergic phenotype of the disease was recorded in 19 (60 %) patients, a quarter of patients had non-allergic phenotype, and 5 (15 %) patients had mixed BA. Results. Before the introduction of genetically engineered biological therapy, patients had an extremely high daily need for emergency medications — about 9 times a day, 4 or more exacerbations were recorded during the previous 12 months before inclusion in the study. After 12 months of additional therapy with Dupilumab, a significant reduction in symptoms was noted — 22 (70 %) patients did not have asthma attacks at all. In 6 patients (19 %), 1 exacerbation of bronchial asthma developed during the next 12 months, which the patients coped with independently using nebulizer therapy at home. Before the start of genetically engineered biological therapy, 10 people (31 %) received systemic glucocorticosteroids (OCS) at a dose of 10 to 5 mg of prednisolone. After 4 months, 22 (70 %) patients receiving hormonal drugs managed to stop them. After 12 months, no patients took OCS. Conclusion. During 12 months of additional therapy with Dupilumab, patients managed to completely stop taking OCS. Exacerbations requiring hospitalization were absent in all patients included in the study. Complete control was achieved by 22 (69 %) subjects, partial control was achieved by 10 (31 %). There was no need for short-acting beta-agonists (SABA) in 27 (85 %) subjects.
Apclusterv: Refinement of Viral Genome Clustering with Affinity Propagation
Authors: Haobin Yao , Ruishi Liang , Zhongyu Xiong , Yanming Zhou 
Published: November 2024

Abstract

Background
Clustering assemblies is a fundamental process of metagenomic analysis. In an era where researchers from a variety of export domains are conducting heavy efforts on viral metagenomics, unsupervised clustering becomes a critical bioinformatics tool to overcome the shortage of viral reference genomes with known taxonomy information.
Results
Here we present Apclusterv, a novel software for clustering viral genome assemblies in an unsupervised manner. Our clustering pipeline relies on gene prediction from contigs and protein sequence alignment. The program is implemented as an open-source Python package. Apclusterv integrates two clustering procedures: Markov Clustering (MCL) and Affinity Propagation (AP). MCL and AP are both clustering algorithms that can determine the number of clusters automatically. Also, they display great synergy in our work. In the task of clustering metagenomic assemblies of viral genomes, our algorithm shows significant improvement in the quality of clusters obtained.
The software freely available at https://github.com/hbyaoherbert/Apclusterv
Conclusions
Assemblies of metagenomic reads are largely incomplete. Apclusterv resolves the limitation of short-reads assembly by identifying confident local alignments through a self-adaptive clustering system. The software can give accurate genera-level viral clusters from metagenomic contigs, which are critical to subsequent classification, Operation Taxonomy Unit (OUT) construction, or gene-sharing network analysis.
GABAergic anti-convulsion prospects of thymol through in vivo and in silico studies
Authors: Islam Muhammad Torequl , Hasan Md. Sakib Al , Ferdous Jannatul , Ansari Irfan Aamer , Ansari Siddique Akber , Islam Md. Amirul 
Published: November 2024

Abstract

The thyme monoterpenoid phenol thymol (THY) possesses diverse biological activities, including anti-convulsant effects. However, the possible action mechanism behind this fact has yet to be discovered. This study aimed to evaluate the anti-convulsant effects of THY with possible molecular insights through in vivo and in silico studies. For this, we performed isoniazid (INH) and pentylenetetrazole (PTZ)-induced convulsion studies in Swiss mice, along with molecular docking studies with the GABAA receptor subunits. Our in vivo study reveals that THY (especially at 25, and 50 mg/kg) significantly (p <0.05) and dose-dependently delayed the onset of convulsion and decreased the duration of convulsion along with the mortality rates, thereby increasing protection in animals alone and/or with the standard GABAergic anti-convulsant drug diazepam (DZP) (2 mg/kg). Interestingly, THY antagonized both INH and PTZ-induced convulsions more profoundly with DZP in animals. In silico studies demonstrate that THY showed a strong binding affinity against GABAA (‒6.6 kcal/mol) by forming several bonds. THY may be a hopeful bioactive to manage convulsions and their associated comorbidities in animals.
Magnetically Dependent Photovoltages in Permalloy Metasurfaces
Authors: Rab Md Afzalur , Keene David , Nesbit Sean , Baker Terence , Noginova Natalia 
Published: November 2024

Abstract

Significant photoinduced voltages observed in permalloy structures consist of two contributions with different origins, which depend on illumination conditions, structure geometry and magnetic field in distinct ways. The first component is the plasmon drag effect voltage closely associated with plasmon propagation. The second contribution is magnetically dependent and can be related to photoinduced gradients in the sample temperature and spin polarization. Possible mechanisms of the effect are discussed.
Development of a Bayesian Subjective Model for Predicting the Clinical Diagnosis of Ebola in the Democratic Republic of the Congo
Authors: Kebela John Kamwina , Kimpanga Prince , Nyandwe Jean , Kokolomami Jack , Chabikuli Odrague , Bwira Steve , Ahuka Steve , Mabela Rostin , Bulenfu Dorothée , Sundika Tresor , Beya Willy , Matadi Bibiche , Malu Gisele , Dyamba Fidèle , Mutombo Annie , Buhalagarha Jean-Paul , Kebela Benoit , Kabasele Bienvenu , Mwamba Dieudonné , Musema Godfroid , Bope Cedrick , Kukangindila Emmanuel , Munyanga Sylvain 
Published: November 2024

Abstract

The symptoms and clinical signs of Ebola virus disease are similar to those of malaria, thus leading to difficulties in terms of making differential diagnoses. Therefore, we developed a subjective model for the clinical diagnosis of Ebola. Excel and SPSS software were used to analyse data. The likelihood ratio, the kappa statistic and various internal evaluation parameters of the model were calculated. These analyses revealed that 4 factors strongly influence the clinical diagnosis of Ebola: haemorrhagic signs, neurological signs, digestive signs and epidemiological links. Among these 4 factors, the combination of haemorrhagic signs and epidemiological links in a patient yields a 60.5% chance of the case being confirmed as Ebola. Therefore, all health care providers in areas with the potential for Ebola must prioritise classifying any patient with these 2 factors as a genuine case of Ebola