bluuebunny/crossref_metadata_2025_split huggingface dataset:
Integrated Radiolaria, benthic foraminifera and conodont biochronology of the pelagic Permian blocks/tectonic slices and geochemistry of associated volcanic rocks from the Mersin Mélange, southern Turkey: Implications for the Permian evolution of the northern Neotethys
Authors: Tekin Ugur Kagan , Okuyucu Cengiz , Sayit Kaan , Bedi Yavuz , Noble Paula J. , Krystyn Leopold , Göncüoglu Mehmet Cemal 
Published: December 2018

AbstractBlocks and tectonic slices within the Mersin Mélange (southern Turkey), which are of Northern Neotethyan origin (Izmir–Ankara–Erzincan Ocean (IAE)), were studied in detail by using radiolarian, conodont, and foraminiferal assemblages on six different stratigraphic sections with well‐preserved Permian succesions. The basal part of the Permian sequence, composed of alternating chert and mudstone with basic volcanics, is assigned to the late Asselian (Early Permian) based on radiolarians. The next basaltic interval in the sequence is dated as Kungurian. The highly alkaline basic volcanics in the sequence are extremely enriched, similar to kimberlitic/lamprophyric magmas generated at continental intraplate settings. Trace element systematics suggest that these lavas were generated in a continental margin involving a metasomatized subcontinental lithospheric mantle source (SCLM). The middle part of the Permian sequences, dated by benthic foraminifera and conodont assemblages, includes detrital limestones with chert interlayers and neptunian dykes of middle Wordian to earliest Wuchiapingian age. Higher in the sequence, detrital limestones are overlain by alternating chert and mudstone with intermittent microbrecciated beds of early Wuchiapingian to middle Changhsingian (Late Permian) age based on the radiolarians. A large negative shift at the base of the Lopingian at the upper part of section is correlated to negative shifts at the Guadalupian/Lopingian boundary associated with the end‐Guadalupian mass extinction event. All these findings indicate that a continental rift system associated with a possible mantle plume existed during the late Early to Late Permian period. This event was responsible for the rupturing of the northern Gondwanan margin related to the opening of the IAE Ocean. When the deep basinal features of the Early Permian volcano‐sedimentary sequence are considered, the proto IAE oceanic crust formed possibly before the end of the Permian. This, in turn, suggests that the opening of the IAE Ocean dates back to as early as the Permian.
A culture shock in dental hygiene: Exploring the management of oral health after head and neck cancer
Authors: Pateman Kelsey A. , Weerakoon Arosha T. , Batstone Martin D. , Ford Pauline J. 
Published: December 2018

AbstractObjectivesManaging oral health after the treatment for head and neck cancer requires meticulous daily oral hygiene practices and regular professional dental care; however, the individual factors and health system structures required to achieve oral health are often not well considered. This study aimed to explore how oral health was understood and managed after head and neck cancer treatment and identify factors that influenced oral health behaviours and dental service utilization.MethodsA qualitative, inductive approach was used for data collection and analysis. Sampling of participants was purposive, using a maximum variation approach, and data were analysed using thematic analysis. Participants were recruited from the maxillofacial clinic at a tertiary facility in Brisbane, Queensland, Australia.ResultsTwenty‐one participants took part in the study. Findings described individual and structural factors that influenced the management of oral health post‐treatment. Individual determinants of oral health behaviours included a cognitive shift towards lifelong oral health; management of unexpected barriers; and management of competing priorities. Structural factors included availability, accessibility of services, and continuity of care. The ability to fund oral health emerged as a salient theme that influenced both individual and structural factors.ConclusionsStrong self‐efficacy and financial and spousal support enhanced the management of oral health, whereas difficulty managing competing issues post‐treatment, such as psychological and financial stress, limited participants’ capacity to prioritize and manage oral health. Policy initiatives are needed to address the structural barriers caused by a lack of timely access to general and preventive dental care post‐treatment.
Basal cell carcinoma of the vulva: a case report and systematic review of the literature
Authors: Renati Sruthi , Henderson Christopher , Aluko Ashley , Burgin Susan 
Published: December 2018

AbstractThe vulva is an unusual site for basal cell carcinoma (BCC). Vulvar BCC accounts for <1% of all BCCs and <5% of all vulvar malignancies. We report the case of an 83 year‐old woman who presented with a 2‐month history of a tender labial growth, with histopathology confirming nodular BCC. We conducted a systematic literature review of the characteristics of reported cases of vulvar BCCs. A comprehensive systematic review of articles indexed for MEDLINE and Embase yielded 96 reports describing 437 patients with 446 BCCs of the vulva. The mean age at presentation was 70 (range 20–100). Most women had no underlying vulvar disease. Approximately 60% of cases were of the nodular subtype. Treatment approach varied widely with over half of cases treated with wide local or local excision. Mohs micrographic surgery (MMS) for vulvar BCC was first reported in 1988 with seven total MMS cases reported. Twenty‐three cases of recurrence have been reported; 21 of these cases after local excision but none following MMS. Vulvar BCC is a rarely reported cancer that affects older women predominantly. MMS represents a promising treatment for BCC in this anatomic location.
Genetic variants of erythropoietin (EPO) and EPO receptor genes in familial erythrocytosis
Authors: Vočanec Danijela , Prijatelj Tinkara , Debeljak Nataša , Kunej Tanja 
Published: December 2018

AbstractObjectivesErythrocytosis is characterized by the expansion of erythrocyte compartment including elevated red blood cell number, hematocrit, and hemoglobin content. Familial erythrocytosis (FE) is a congenital disorder with different genetic background. Type 1 FE is primary FE caused by mutation in erythropoietin receptor gene (EPOR). Type 2‐5 FE are secondary FEs caused by mutations of genes involved in oxygen sensing pathway important for erythropoietin (EPO) regulation. In the present study, we summarized associations between EPOR and EPO gene variations with development of FE and searched for genetic variants located within regulatory regions.MethodsPublications reporting EPOR and EPO sequence variants associated with FE or clinical features of erythrocytosis were retrieved from PubMed and WoS. In silico, sequence reanalysis was performed using Ensembl genomic browser, release 89 to screen for variants located within regulatory regions.ResultsTo date, 28 variants of the EPOR and seven variants of the EPO gene have been associated with erythrocytosis or upper hematocrit. Sequence variants were also found to be present within regulatory regions.ConclusionsRole of variants in regulatory regions of the EPO gene should be further investigated.
Penile intraepithelial neoplasia: Nomenclature, incidence and progression to malignancy in the Netherlands
Authors: Hoekstra Robert J , Trip Evelien J , ten Kate Fybo JW , Horenblas Simon , Lock MTW Tycho 
Published: December 2018

ObjectiveTo determine the incidence of penile intraepithelial neoplasia in the Netherlands using a nationwide histopathology registry and to discuss the nomenclature of premalignant penile lesions.MethodsData from patients in the Netherlands diagnosed with a premalignant penile lesion between January 1998 and December 2007 were collected from the nationwide histopathology registry (PALGA); this database covers all pathology reports of inhabitants in the Netherlands. The premalignant lesions included were erythroplasia of Queyrat; Bowen's disease; bowenoid papulosis; mild, moderate and severe dysplasia; and carcinoma in situ of the penis. The terminology used in the pathological reports was translated to penile intraepithelial neoplasia. The grading was made analogous to that of vulvar premalignant lesions.ResultsThe PALGA database enrolled 380 patients with premalignant penile lesions. Severe premalignant lesions, penile intraepithelial neoplasia III, were found in 254 patients (67%), penile intraepithelial neoplasia II in 84 (22%) and penile intraepithelial neoplasia I in 42 patients (11%). Most lesions were located on the prepuce (45%), followed by glans (38%) and shaft (3%). The median age of patients with penile intraepithelial neoplasia was 58 years. Progression to malignant disease occurred (2% for penile intraepithelial neoplasia I vs 7% for penile intraepithelial neoplasia III) in 26 patients.ConclusionsPenile intraepithelial neoplasia is a rarely diagnosed condition. Because of the wide variation of terms used for premalignant intraepithelial neoplasia of the penis, we recommend restricting this nomenclature to penile intraepithelial neoplasia.
Quality criteria, instruments, and requirements for nursing documentation: A systematic review of systematic reviews
Authors: De Groot Kim , Triemstra Mattanja , Paans Wolter , Francke Anneke L. 
Published: December 2018

AbstractAimTo obtain an overview of existing evidence on quality criteria, instruments, and requirements for nursing documentation.DesignSystematic review of systematic reviews.Data sourcesWe systematically searched the databases PubMed and CINAHL for the period 2007–April 2017. We also performed additional searches.Review methodsTwo reviewers independently selected the reviews using a stepwise procedure, assessed the methodological quality of the selected reviews, and extracted the data using a predefined extraction format. We performed descriptive synthesis.ResultsEleven systematic reviews were included. Several quality criteria were described referring to the importance of following the nursing process and using standardized nursing terminologies. In addition, some evidence‐based instruments were described for assessing the quality of nursing documentation, such as the D‐Catch. Furthermore, several requirements for formats and systems of electronic nursing documentation were found that refer to the importance of user‐friendliness and development in consultation with nursing staff.ConclusionAligning documentation with the nursing process, using standard terminologies, and using user‐friendly formats and systems appear to be important for high‐quality nursing documentation. The lack of evidence‐based quality indicators presents a challenge in the pursuit of high‐quality nursing documentation.Impact

There is uncertainty in nursing practice about which criteria have to be met to achieve high‐quality documentation.

Aligning documentation with the nursing process, using standard terminologies, and using user‐friendly formats and systems appear to be important.

These findings can help nursing staff and care organizations enhance the quality of nursing documentation.
Nucleoporin 107 facilitates the nuclear export of Scn5a mRNA to regulate cardiac bioelectricity
Authors: Guan Yi , Gao Xueting , Tang Qiuyu , Huang Lin , Gao Siyun , Yu Shuai , Huang Jiale , Li Jun , Zhou Daizhan , Zhang Yangyang , Shi Dan , Liang Dandan , Liu Yi , Li Li , Cui Yingyu , Xu Liang , Chen Yi‐Han 
Published: December 2018

AbstractNucleoporins (Nups) are known to be functional in nucleo‐cytoplasmic transport, but the roles of nucleoporins in nonproliferating cells, such as cardiac myocytes, are still poorly understood. In this study, we report that Nup107 regulates cardiac bioelectricity by controlling the nucleo‐cytoplasmic trafficking of Scn5a mRNA. Overexpression of Nup107 induced the protein expression of Scn5a rather than that of other ion channels, with no effects of their mRNA levels. The analysis for the protein production demonstrated Nup107‐facilitated transport of Scn5a mRNA. Using RIP‐PCR and luciferase assay, we found that the 5′‐UTR of Scn5a mRNA was not involved in the interaction, whereas the spatial interaction between Nup107 protein and Scn5a mRNA was formed when Scn5a mRNA passing through the nuclear pore. Functionally, Nup107 overexpression in neonatal rat ventricle myocytes significantly increased the currents of Scn5a‐encoded INa channel. Moreover, the close correlation between Nup107 and Nav1.5 protein expression was observed in cardiomycytes and heart tissues subjected to hypoxia and ischaemic insults, suggesting a fast regulation of Nup107 on Nav1.5 channel in cardiac myocytes in a posttranscriptional manner. These findings may provide insights into the emergent control of cardiac electrophysiology through Nup‐mediated modulation of ion channels.
RNF168 facilitates proliferation and invasion of esophageal carcinoma, possibly via stabilizing STAT1
Authors: Yu Na , Xue Min , Wang Weilong , Xia Dongxue , Li Yajie , Zhou Xiaofeng , Pang Dan , Lu Kui , Hou Jinghan , Zhang Aijia , Zhuang Ting , Wang Lidong , Chang Tingmin , Li Xiumin 
Published: December 2018

AbstractOesophageal cancer ranks as one of the most common malignancy in China and worldwide. Although genome‐wide association studies and molecular biology studies aim to elucidate the driver molecules in oesophageal cancer progression, the detailed mechanisms remain to be identified. Interestingly, RNF168 (RING finger protein 168) shows a high frequency of gene amplification in oesophageal cancer from TCGA database. Here, we report an important function for RNF168 protein in supporting oesophageal cancer growth and invasion by stabilizing STAT1 protein. RNF168 gene is amplified in oesophageal cancer samples, which tends to correlate with poor prognosis. Depletion RNF168 causes decreased cell proliferation and invasion in oesophageal cancer cells. Through unbiased RNA sequencing in RNF168 depleted oesophageal cancer cell, we identifies JAK‐STAT pathway is dramatically decreased. Depletion RNF168 reduced JAK‐STAT target genes, such as IRF1, IRF9 and IFITM1. Immuno‐precipitation reveals that RNF168 associates with STAT1 in the nucleus, stabilizing STAT1 protein and inhibiting its poly‐ubiquitination and degradation. Our study provides a novel mechanism that RNF168 promoting JAK‐STAT signalling in supporting oesophageal cancer progression. It could be a promising strategy to target RNF168 for oesophageal cancer treatment.
First report of the invasive Reticulitermes flavipes (Kollar, 1837) (Blattodea, Rhinotermitidae) in the Canary Islands
Authors: Hernández‐Teixidor David , Suárez Daniel , García Javier , Mora David 
Published: December 2018

AbstractReticulitermes flavipes, one of the most harmful subterranean termite pests, is reported for the first time from Tenerife (Canary Islands, Spain). Cytochrome oxidase II was sequenced from five specimens in order to confirm the identification. To date, this invasive species has been detected in a limited area in the northeast of the island, affecting buildings, crops and native plant species. Another colony with the identical haplotype found in the southwest, 60 km away from the main population, indicates that this invasive insect may be more widespread over the island.
Interventions to Improve Gait in Older Adults with Cognitive Impairment: A Systematic Review
Authors: Zhang Weihong , Low Lee‐Fay , Gwynn Josephine Diana , Clemson Lindy 
Published: December 2018

ObjectivesTo review intervention programs that measure gait to investigate what features of the intervention may contribute to improving gait in older adults with cognitive impairment or dementia.DesignSystematic review using Medline, Cinahl, Scopus, PsychInfo, Amed, Embase, Web of Science, and PubMed for original research published in English between January 1, 2000, and July 23, 2018, to identify interventional controlled trials. Narrative synthesis was undertaken.ResultsOf 6,379 citations, 36 articles met inclusion criteria. Interventions were categorized as medication or medical devices (8 studies), exercise (19 studies), and exercise plus cognitive training (9 studies). Antidementia medication may improve gait variability in people with Alzheimer's disease. Exercise programs focusing on strength and balance training, especially when combined with functional mobility training, improve gait in people with mild cognitive impairment or dementia. Exercise plus cognitive training programs combining strength and balance training, functional mobility training, and training on attention and executive function also improve gait.ConlusionPhysical and cognitive factors affect gait performance, and both should be addressed in intervention programs. Physical exercises including functional mobility training, especially walking, have better results than physical programs with only static, resistance, and flexibility training. Cognitive intervention should be concomitant with physical exercises rather than separate, with a focus on attention and executive function. Combining physical training with cognitive training in a functional context may assist older adults with cognitive impairment generalize from training to everyday activity.J Am Geriatr Soc 67:381–391, 2019.
Quality of End‐of‐Life Care and Its Association with Nurse Practice Environments in U.S. Hospitals
Authors: Lasater Karen B. , Sloane Douglas M. , McHugh Matthew D. , Aiken Linda H. 
Published: December 2018

ObjectivesThe purpose of this study is twofold: (1) to describe the quality of end‐of‐life care in US hospitals from the perspective of hospital nurses; and (2) to evaluate the relationship between the nurse practice environment and end‐of‐life care quality.DesignCross‐sectional analysis of multiple linked secondary data sources.PARTICIPANTS and SETTINGA total of 12,870 direct care registered nurses in 491 acute‐care hospitals.MeasurementsMeasures of end‐of‐life care quality and nurse practice environment were derived from the 2016 RN4CAST‐US survey of nurses. Nurses reported on end‐of‐life care quality for patients for whom death within a year would not be surprising. Nurse practice environment was measured using the Practice Environment Scale of the Nursing Work Index, a National Quality Forum validated scale.ResultsMost nurses gave their hospitals an unfavorable evaluation of end‐of‐life care overall (58%) and said patients often experience painful procedures that were unlikely to change their outcome (53%). The best predictor of poor quality was the nurse practice environment. Nurses in the best environments were 55% less likely than nurses in poor environments to rate their hospital's overall end‐of‐life care quality unfavorably (odds ratio = 0.45; 95% confidence interval = 0.39–0.52; P < .001).ConclusionQuality of end‐of‐life care in US hospitals is imperfect and is significantly worse in hospitals with poor nurse practice environments than in hospitals with the best environments. This study reinforces the importance of nurses in providing high‐quality end‐of‐life care. J Am Geriatr Soc 67:302–308, 2019.
Post‐Acute Care among Older Adults with Stage I to III Colorectal Cancer
Authors: Kenzik Kelly M. , Williams Grant R. , Bhatia Smita , Balentine Courtney J. 
Published: December 2018

BACKGROUNDLittle information is available on the long‐term use of post‐acute care among older patients with colorectal cancer (CRC), relative to individuals without cancer. This study examines the use of post‐acute care among older cancer survivors (>65 y) with CRC and compares it with noncancer patients up to 5 years from surgery.DESIGNRetrospective cohort.SETTINGSEER‐Medicare.PARTICIPANTSPatients treated for stage I to III CRC between January 1, 2000, and December 31, 2011 (n = 40 812) and noncancer Medicare beneficiaries hospitalized for noncancer treatment matching on age, sex, race, comorbidity, and Medicaid dual eligibility.MEASUREMENTSIncident post‐acute care claims (skilled nursing, long‐term care facility, and home health) from 0 to 100 days, 101 to 365 days, and 1 to 5 years from hospitalization.RESULTSThe median age was 77 years. All patients had surgery, 34% received chemotherapy, and 27% received surgery and adjuvant therapy. The cumulative incidence of any post‐acute care within 100 days of hospitalization was 45.7% for stage III, 37.9% for stage I/II, and 39% for controls (p < .001). Within the CRC cohort only, the cumulative incidence of post‐acute care was 2.9% (stage I/II) and 4.2% (stage III, p < .001) from 101 to 365 days and 15.8% (stage I/II) and 16.9% (stage III, p < .001) from 1 to 5 years. Increasing age, ostomies, and neoadjuvant or adjuvant therapy were associated with increased hazard of all post‐acute patients within 100 days from hospitalization. From 1 to 5 years from diagnosis, adjuvant therapy was associated with greater exclusive home health care use.CONCLUSIONSSurvivorship planning among older CRC patients should include discussions of post‐acute care following cancer therapy, even several years after treatment. J Am Geriatr Soc 67:937–944, 2019.
Patient and carer experience of blended diet via gastrostomy: a qualitative study
Authors: Phillips G. 
Published: December 2018

AbstractBackgroundHome enteral feeding is becoming increasingly prevalent within the UK. The use of commercial prescription formula is considered best practice; however, increasingly, patients are choosing to use blended diet via gastrostomy. There is anecdotal evidence suggesting both physical and social benefits, although there are concerns regarding the safety and efficacy of this method of feeding. The present study explores the experiences of patients who are currently using or have used this method of feeding in the past.MethodsPatients currently using or having previously used blended diet via gastrostomy were identified. Patients and their carers, where applicable, were invited to participate in a semi‐structured interview. The data were transcribed and themes were identified.ResultsThematic analysis of the data collected showed that patients had an overall positive experience of blended diet with few or no identified disadvantages. Participants reported improvements in gastrointestinal symptoms, as well as general wellbeing, in addition to the social benefits of their family member being included in family mealtimes. Reference was made to the lack of support for this method of feeding and the desire for blended diet to be offered as an alternative to commercial enteral feed.ConclusionsThis research highlights the benefits of blended diet via gastrostomy as an alternative to commercial formula. More research is needed to develop evidence‐based guidelines for patients and the healthcare professionals supporting them.