bluuebunny/crossref_metadata_2025_split huggingface dataset:
Carcinoembryonic Antigen and Breast Carcinoma Antigen (CA 15.3) in Preoperative Staging and Postoperative Monitoring of Patients with Carcinoma of the Breast
Authors: Omar Y.T. , Behbehani A.E. , Al-Naqeeb N. , Motawy M.M. , Folldi M.O. , Awwad A.H. , Nasralla M. Y. , Szymendera J.J. 
Published: April 2018

Serum levels of carcinoembryonic antigen (CEA) and breast carcinoma antigen (CA 15.3) were determined in patients with breast carcinoma: in 129 before initial surgical or nonsurgical treatment and in 134 afterwards. Before any initial treatment, CEA was elevated in 15% of patients with Stage IV disease and CA 15.3 was high in 11% with Stage III and 48% with Stage IV. While monitoring management active disease was associated with elevated serum CEA in 66% of the patients, with elevated CA 15.3 in 73% and with at least one of the markers elevated in 86%. Both tests had high specificity (93% and 98%). The rise in serum CEA and, even more so, of serum CA 15.3 roughly paralleled the increase in bulk of the tumor: from locoregional disease through metastases to the lungs, bones, lungs with bones, and liver. Decreases in the levels of serum CEA and CA 15.3 reflected response to therapy, increases in the level of at least one marker - treatment failure, and levels fluctuating above the normal range indicated stationary disease. During follow-up, the predictive value of a negative test (levels within the normal range), suggesting that the patient might be free of disease, was 61% for CEA alone, 67% for CA 15.3 alone, and 80% for the two tests combined. We conclude that an elevated serum level of only one of the markers was useful for staging, implying advanced disease. Determination of both markers jointly was useful for monitoring the effectiveness of the therapy and for follow-up aimed at detection of relapse.
Sialic Acid, Ferritin and CEA Levels in Peripheral Blood and Blood Draining from the Tumor in Breast Cancer
Authors: Monti M. , Catania S. , Locatelli E. , Scazzoso A. , Calzaferri G. , Cunietti E. 
Published: April 2018

Concentrations of total serum N-acetyl-neuraminic acid, carcinoembryonic antigen, ferritin, lactate dehydrogenase, creatine phosphokinase and total proteins were measured in both tumor drainage blood (axillary vein) and in peripheral blood taken during surgery from 44 breast cancer patients. There were no significant differences in any of the markers between mean values in peripheral and tumor drainage blood, between cancer patients and healthy controls, between patients with or without axillary lymph node metastases, or according to the site of breast mass.
A Preliminary Study of Brain Gliomas with H17E2 Monoclonal Antibody: Immunoscintigraphy and Pharmacokinetics
Authors: Skarlos DV. , Malamitsi J. , Sivolapenko G B. , Demakopoulos N. , Avgoustatos G. , Koutoulidis C. , Epenetos Aa. 
Published: April 2018

Ten patients with relapsing high grade brain gliomas and one patient with low grade glioma were studied with a monoclonal antibody (H17E2) against placental alkaline phosphatase. In addition 2 patients with relapsing high grade glioma were studied with a non specific antibody (4D513/2118). 1 mCi of Iodine-131-labelled H17E2 was administered intracarotidly (i.c.) in two, and intravenously (i.v.) in 9 patients. Immunoscintigrams were taken at 0, 2, 24, 48 and 72 hours. Radioactivity was monitored in blood and urine. Tumour/non-tumour ratios were estimated (max. 2.45). All high grade gliomas receiving specific antibody irrespective of the route of administration, gave a positive immunoscintigraphic pattern, increasing in intensity with time. Disappearance of radioactivity in blood was biexpontential with a long component over 30 hours. Urinary excretion of radioactivity ranged from 3.7–21.7% of administered dose/day. The patient with low grade glioma and the patients receiving non specific monoclonal antibody showed a negative pattern, a fast blood clearance and a high urinary excretion. We conclude that a) Iodine-131 labelled H17E2 proved to be stable in vivo and produced satisfactory tumour localisation and b) i.v. route was as good as i.c.
Radioimmunotherapy Trials in Germ Testicular Carcinoma: A Phase I Study
Authors: Riva P. , Marangolo M. , Tison V. , Moscatelli G. , Franceschi G. , Spinelli A. , Rosti G. , Morigi P. , Riva N. , Tirindelli D. 
Published: April 2018

Two patients with germ cell testicular cancer were submitted to radioimmunotherapy (RIT) by using the monoclonal antibody 131I-radiolabelled (MoAb) H17E2, raised against placental alkaline phosphatase (PLAP). Both patients had been previously treated with repeated chemotherapy regimens assisted by autologous bone marrow transplant (ABMT), that, in the end were unsuccessful, thus necessitating further experimental treatment. RIT was well tolerated and the targeting of multiple neoplastic lesions was satisfactory. Nevertheless, the clinical results of treatment were minimal owing to the extension of the tumour. The data obtained suggest the possibility of applying this form of treatment in patients with minimal residual disease after previous traditional chemotherapy regimens.
Elimination Kinetics of Prostate-Specific Antigen Serum and Urine
Authors: Semjonow A. , Hamm M. , Rathert P. 
Published: April 2018

The serum half-life of prostate-specific antigen (PSA) was calculated in 66 patients subsequent to radical prostatectomy. Comparing serum half-life to disease outcome in 37 patients after a minimum follow-up of two years, it was found that PSA serum half-life identifies patients with residual disease earlier and more reliably than the presence or absence of detectable PSA levels postoperatively. It is suggested that residual tumor affects the half-life by contributing to the serum level of PSA. When PSA serum half-life was calculated solely in potentially cured patients, we found a half-life of 1.6 days, which is considerably shorter than in previous reports based on patient populations regardless of the outcome of disease in the follow-up. To elucidate the route of PSA elimination, serial urine PSA levels were determined before and after radical prostatectomy, revealing strong evidence for the assumption that PSA is not eliminated by the kidneys in its unchanged form.
Comparison of Cyfra 21–1, Tpa and Tps in Lung Cancer, Urinary Bladder Cancer and Benign Diseases
Authors: Stieber P. , Dienemann H. , Hasholzner U. , Fabricius P.G. , Schambeck C. , Weinzierl M. , Poley S. , Samtleben W. , Hofmann K. , Meier W. , Untch M. , Fateh-Moghadam A. 
Published: April 2018

Recently CYFRA 21–1, a new tumor marker measuring a fragment of cytokeratin 19, was introduced and proved to be suitable for therapy monitoring and follow-up of non-small cell lung carcinomas (NSCLC), in particular squamous cell carcinomas. Besides CYFRA 21–1 there are two other tumor markers, tissue polypeptide antigen (TPA) and tissue polypeptide-specific antigen (TPS), which also measure various cytokeratins in serum. In a retrospective study we investigated the clinical significance of these three cytokeratin markers in lung cancer and in carcinoma of the urinary bladder. For this purpose we investigated the sera of 50 healthy persons, 273 patients with various benign diseases, 218 patients with histologically proven lung cancer and 88 patients with carcinoma of the urinary bladder. In a first step the specificity was established for the different reference groups and the cutoff values were fixed at a specificity of 95%. In lung cancer the single and combined sensitivities were calculated versus benign lung diseases (n = 58) as reference group. With single determinations CYFRA 21–1 proved to have the highest sensitivity in lung cancer in general (61%), in non-small cell lung carcinomas (64%), in squamous cell carcinomas (79%), in adenocarcinomas (54%) and in large cell carcinomas (65%). In small cell lung carcinomas (SCLC) NSE was confirmed to be the marker of choice (55%). With combined determinations a clear increase in sensitivity could only be reached in large cell carcinomas (CYFRA 21–1 + TPA: 77%) and in small cell carcinomas (CYFRA 21–1 + NSE: 62%). In cancer of the urinary bladder the sensitivities were established versus benign urological diseases (n = 73). CYFRA 21–1 showed with 38% true positive test results the highest sensitivity compared to TPA (27%) and TPS (23%). From our investigations it was evident that TPA detects at least partially the same substance as CYFRA 21–1 (the sensitivities compared to the markers TPS, CEA, SCC and NSE were rather high, but not as high as for CYFRA 21–1) whereas TPS represents a completely different parameter of clinical chemistry (lowest number of true positive test results over the whole investigation), which apparently measures something completely different. These findings cleary correspond with the very recent results of immunoblotting comparing CYFRA 21–1, TPA and TPS.
Soluble Interleukin-2 Receptors in Patients with Advanced Colorectal Carcinoma
Authors: Pavlidis N. , Nicolaides C. , Bairaktari E. , Kalef-Ezra J. , Athanassiadis A. , Seferiadis C. , Fountzilas G. 
Published: April 2018

The levels of soluble interleukin-2 receptors (sIL-2R) were measured in the serum of 52 patients with advanced colorectal carcinoma and compared to CEA and CA 19-9 levels. Twenty-five normal, age and sex-matched individuals served as controls. Seventy-five per cent of the patients had increased mean serum levels of sIL-2R (1539 ± 155 U/ml), while normal controls had mean levels of 555 ± 31 U/ml (p < 0.001). The relationship with hepatic or lymph nodal metastases showed no statistically significant difference (p=0.34 and p=0.47, respectively). Serum sIL-2R levels showed a linear correlation with CEA (p < 0.05). Patients with lower pretreatment sIL-2R levels (less than 1.200 U/ml) had a longer survival than patients with higher initial levels (more than 1.200 U/ml) (p=0.0049). In conclusion, the present work shows that the serum levels of sIL-2R: a) are elevated in patients with advanced colorectal cancer, b) have no relationship with the type of metastases, c) correlate with serum CEA and d) have a prognostic value for survival.
Can Patients Practice Strenuous Sports After Uncemented Ceramic-on-Ceramic Total Hip Arthroplasty?
Authors: Bonnin Michel P. , Rollier Jean-Charles , Chatelet Jean-Christophe , Ait-Si-Selmi Tarik , Chouteau Julien , Jacquot Laurent , Hannink Gerjon , Saffarini Mo , Fessy Michel-Henri 
Published: April 2018

Background: Patients are often concerned about returning to sports after total hip arthroplasty (THA). Purpose: To (1) evaluate sports participation and motivation rates in a large cohort of patients who underwent uncemented THA with ceramic-on-ceramic bearings and (2) determine whether patients’ participation was associated with their motivation for each sport, preoperative demographics, or patient-reported outcomes. Study Design: Case-control study; Level of evidence, 3. Methods: We surveyed 1310 patients (aged <75 years) who underwent uncemented ceramic-on-ceramic THA and collected levels of motivation and participation for 22 different sports as well as patient-reported outcome measure scores. A total of 1042 patients (1206 hips) returned questionnaires; the mean age at index surgery was 60.6 ± 8.8 years. Results: At least 51% of patients participated regularly or frequently in at least 1 light sport, 73% in at least 1 moderate sport, and 20% in at least 1 strenuous sport. Sports participation was strongly correlated with motivation ( r = 0.97, P < .001) but not with level of discomfort ( r = 0.22, P = .292). Participation in strenuous sports was significantly associated with age, body mass index, and sex. There were significant differences among patients who practiced various categories of sports as determined using the Oxford Hip Score ( P = .008), but not with regard to the Forgotten Joint Score ( P = .054). Conclusion: Only 20% of patients practiced strenuous sports regularly or frequently after THA, regardless of pain or discomfort. Participation in sports after THA is strongly correlated with motivation but not with level of discomfort. Longer term studies with a greater focus on complications and survival are necessary to determine whether high-impact sports compromise patient safety or implant longevity.
Imaging the Deep Choroidal Vasculature Using Spectral Domain and Swept Source Optical Coherence Tomography Angiography
Authors: Diaz J. Daniel , Wang Jay C. , Oellers Patrick , Lains Inês , Sobrin Lucia , Husain Deeba , Miller Joan W. , Vavvas Demetrios G. , Miller John B. 
Published: April 2018

Purpose: To evaluate the deeper choroidal vasculature in eyes with various ocular disorders using spectral domain (SD) optical coherence tomography angiography (OCTA) and swept source (SS) OCTA. Methods: Patients underwent OCTA imaging with either SD-OCTA (Zeiss Cirrus Angioplex or Optovue AngioVue) or SS-OCTA (Topcon Triton). Retinal pigment epithelium (RPE) integrity, structural visualization of deep choroidal vessels on en face imaging, and OCTA of deep choroidal blood flow signal were analyzed. Choroidal blood flow was deemed present if deeper choroidal vessels appeared bright after appropriate segmentation. Results: Structural visualization of choroidal vessels was feasible in all eyes by en face imaging. In both SD-OCTA and SS-OCTA, choroidal blood flow signal was present in all eyes with overlying RPE atrophy (100% of eyes with RPE atrophy, 28.6% of all imaged eyes, P < .001). Conclusions: While choroidal vessels can be visualized anatomically in all eyes by en face imaging, choroidal blood flow detection in deep choroidal vessel is largely restricted to areas with overlying RPE atrophy. Intact RPE acts as a barrier for reliable detection of choroidal flow using current OCTA technology, inhibiting evaluation of flow in deeper choroidal vessels in most eyes.
Extreme enrichment of selenium in the Apliki Cyprus-type VMS deposit, Troodos, Cyprus
Authors: Martin Andrew J. , McDonald Iain , MacLeod Christopher J. , Prichard Hazel M. , McFall Katie 
Published: April 2018

ABSTRACTThe Troodos ophiolite Cyprus hosts the type locality for Cyprus-type, mafic volcanogenic massive sulfide (VMS) deposits. Regional soil geochemical data for Troodos are highly variable with the Solea graben, one of three regional graben structures on Cyprus, showing enrichment in Te and Se. Of the three VMS sampled within the Solea graben, Apliki exhibits the most significant enrichment in Se. Samples from the South Apliki Breccia Zone; a zone of hematite-rich breccia containing euhedral pyrite and chalcopyrite, contain up to 4953 and 3956 ppm Se in pyrite and chalcopyrite, respectively. Four paragenetic stages are identified at Apliki and different generations of pyrite are distinguishable using trace-element chemistry analysed via laser ablation inductively coupled plasma mass spectrometry. Results indicate stage I pyrite formed under reduced conditions at high temperatures >280°C and contains 182 ppm (n = 22 σ = 253) Se. Late stage III pyrite which is euhedral and overprints chalcopyrite and hematite is enriched in Se (averaging 1862 ppm; n = 23 σ = 1394). Sulfide dissolution and hematite formation displaced large amounts of Se as hematite cannot accommodate high concentrations of Se in its crystal structure. The mechanisms proposed to explain the pronounced change in redox are twofold. Fault movement leading to localized seawater ingress coupled with a decreasing magmatic flux that generated locally oxidizing conditions and promoted sulfide dissolution. A Se/S ratio of 9280 indicates a probable magmatic component for late stage III pyrite, which is suggested as a mechanism explaining the transition from oxidizing back to reduced conditions. This study highlights the significance of changes in redox which promote sulfide dissolution, mobilization and enrichment of Se.
Bulbar impairment score and survival of stable amyotrophic lateral sclerosis patients after noninvasive ventilation initiation
Authors: Sancho Jesús , Martínez Daniel , Bures Enric , Díaz José Luis , Ponz Alejandro , Servera Emilio 
Published: April 2018

There is general agreement that noninvasive ventilation (NIV) prolongs survival in amyotrophic lateral sclerosis (ALS) and that the main cause of NIV failure is the severity of bulbar dysfunction. However, there is no evidence that bulbar impairment is a contraindication for NIV. The aim of this study was to determine the effect of bulbar impairment on survival in ALS patients with NIV.ALS patients for whom NIV was indicated were included. Those patients who refused NIV were taken as the control group.120 patients who underwent NIV and 20 who refused NIV were included. The NIV group presented longer survival (median 18.50 months, 95% CI 12.62–24.38 months) than the no-NIV group (3.00 months, 95% CI 0.82–5.18 months) (p<0.001) and also in those patients with severe bulbar dysfunction (13.00 months (95% CI 9.49–16.50 months)versus3.00 months (95% CI 0.85–5.15 months), p<0.001). Prognostic factors for ALS using NIV, adjusted for NIV failure, were severity of bulbar dysfunction (hazard ratio (HR) 0.5, 95% CI 0.92–0.97; p=0.001) and time spent with oxygen saturation measured by pulse oximetry <90% (%sleepSpO2<90) using NIV (HR 1.12, 95% CI 1.01–1.24; p=0.02).Severe bulbar impairment in ALS does not always prevent NIV from being used, but the severity of bulbar dysfunction at NIV initiation and %sleepSpO2<90 while using NIV appear to be the main prognostic factors of NIV failure in ALS.
Fank1 and Jazf1 promote multiciliated cell differentiation in the mouse airway epithelium
Authors: Johnson Jo-Anne , Watson Julie K. , Nikolić Marko Z. , Rawlins Emma L. 
Published: April 2018

ABSTRACT
The airways are lined by secretory and multiciliated cells which function together to remove particles and debris from the respiratory tract. The transcriptome of multiciliated cells has been extensively studied, but the function of many of the genes identified is unknown. We have established an assay to test the ability of over-expressed transcripts to promote multiciliated cell differentiation in mouse embryonic tracheal explants. Overexpression data indicated that Fibronectin type 3 and ankyrin repeat domains 1 (Fank1) and JAZF zinc finger 1 (Jazf1) promoted multiciliated cell differentiation alone, and cooperatively with the canonical multiciliated cell transcription factor Foxj1. Moreover, knock-down of Fank1 or Jazf1 in adult mouse airway epithelial cultures demonstrated that these factors are both required for ciliated cell differentiation in vitro. This analysis identifies Fank1 and Jazf1 as novel regulators of multiciliated cell differentiation. Moreover, we show that they are likely to function downstream of IL6 signalling and upstream of Foxj1 activity in the process of ciliated cell differentiation. In addition, our in vitro explant assay provides a convenient method for preliminary investigation of over-expression phenotypes in the developing mouse airways.
This article has an associated First Person interview with the first author of the paper.
Surveillance imaging for sporadic renal angiomyolipoma less than 40 mm: lessons learnt and recommendations from the experience of a large district general hospital
Authors: Chan KE , Chedgy ECP , Bent CL , Turner KJ 
Published: April 2018

IntroductionSporadic renal angiomyolipomas, although benign in natural can cause life-threatening spontaneous haemorrhage. Surveillance of smaller lesions is recommended but there is no guidance on the surveillance interval or modality. Our aim was to study our sporadic angiomyolipoma population to determine the growth rate, factors that were associated with a higher growth rate and design a surveillance programme.Materials and methodsAll sporadic renal angiomyolipomas diagnosed between September 2009 and March 2015 were included. Patients with a diagnosis of tuberous sclerosis were excluded.ResultsA total of 217 sporadic renal angiomyolipomas were diagnosed. The median follow-up was 24 months (range 10–118 months). The median size at diagnosis was 9.00 mm with a mean growth rate of 0.13 mm/year (standard deviation 0.88). One hundred and fifty angiomyolipomas (69%) were shown to have negative or zero growth. In the remaining 67, 59 had a growth rate of less than 2.00 mm/year. Size of angiomyolipoma, tumour burden and age were not associated with a higher growth rate on multivariate analysis.ConclusionThe majority of sporadic angiomyolipomas are small and do not grow. Our practice is to perform surveillance for those greater than 20 mm, with five-yearly ultrasound scans for 21–29 mm, and two-yearly surveillance for 30–39 mm tumours.
FORMAÇÃO DE EDUCADORES DO PEJA: AÇÃO COLETIVA, REFLEXÃO CONTEXTUALIZADA E PROJETOS DE TRABALHO
Authors: Girotto Cyntia G.G. Simões , Miguel José Carlos , Miller Stela 
Published: April 2018

O presente artigo tem como objetivo evidenciar uma das possibilidades de formação dos profissionais de EJA (Educação de Jovens e Adultos), qual seja, a formação contínua, que acompanha a trajetória de trabalho do educador com seus alunos, tendo como suporte sua inserção em projeto de pesquisa, na perspectiva de um processo coletivo que envolve ação-reflexão-ação. Objetiva, também, pôr em discussão as bases sobre as quais podem ser construídas as aprendizagens na área de matemática, leitura e escrita.
EDUCAÇÃO E INFÂNCIA: ENSAIO SOBRE PODER E CONTROLE
Authors: Mesomo Aliandra Cristina 
Published: April 2018

Este texto pretende problematizar questões voltadas à educação no momento atual, procurando refletir sobre as práticas educacionais institucionais a partir de situações de poder nelas verificadas. Para tanto, toma os estudos de Michel Foucault sobre a dominação dos corpos, tempos e espaços nas instituições (entre elas a escola) como referencial teórico elementar para a fundamentação das problematizações. A faixa etária escolar sobre a qual serão feitas as considerações e reflexões educacionais refere-se às crianças de 0 a 6 anos, ou seja, a Educação Infantil. No entanto, muitas das considerações podem ser estendidas e entendidas no contexto escolar mais amplo.
“HISTÓRIAS COM PROBLEMAS” UMA FORMA DE EDUCAR PARA A NUMERACIA E PARA A LITERACIA
Authors: Sardinha Maria de Fátima Morais , Azevedo Fernando José de Fraga , Palhares Pedro Manuel Baptista 
Published: April 2018

As “histórias com problemas” são uma estratégia de ensino que visa, através de uma abordagem interdisciplinar, ligar a Língua Portuguesa à Matemática. Este artigo analisa parte de um estudo realizado no âmbito de uma investigação de mestrado numa turma do 3.º ano do 1.º Ciclo do Ensino Básico, em Portugal, no ano lectivo de 2002/03. Pretendeu-se, através da implementação deste método de ensino, analisar se as histórias com problemas promoviam uma educação para a literacia e para a numeracia. São aqui analisados os dados recolhidos através de observação, acompanhada de gravação vídeo, numa situação em que os alunos, após resolverem um problema matemático não rotineiro, tinham que criar uma história para melhor contextualizar o problema. A partir desta análise são apresentadas as conclusões e reflexões sobre a eficácia deste método no desenvolvimento de competências de numeracia e literacia.