bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reading-to-write tasks for professional purposes in Spanish as a foreign language
Authors: Vangehuchten Lieve , Leijten Mariëlle , Schrijver Iris 
Published: December 2018

Abstract
A reading-to-write task is a complex cognitive activity. The aim of this study is to gain insight into the difficulties that advanced learners of Spanish as a foreign language for professional communication purposes experience when they have to perform a reading-to-write task. This insight will help to improve writing instruction and training for this particular type of students. In this study, 19 students of a one-year master’s programme in multilingual professional communication (level B2–C1 of the Common European Framework of Reference for Languages, Council of Europe, 2001) were asked to carry out a reading-to-write task in Dutch, their mother tongue, and in Spanish at the beginning of the academic year. This task was repeated at the end of the academic year. On both occasions, the task was writing an informative synthesis of approximately 200–250 words using three digital source texts in Dutch and in Spanish pertaining to different text genres (i.e., a report from the European Union, a website, a newspaper article). The three source texts varied in lexical and syntactical complexity, content, style and discursive characteristics. All written products were evaluated by two independent raters. We found no general improvement in the reading-to-write task between the two moments, neither in the L1 nor in the L2. We did not find an improvement at sentence, text, or discourse level either. We will explore several explanations for this lack of improvement, based on theoretical models of foreign language acquisition and recent empirical writing research.
Reliability and validity of field‐based fitness tests in youth soccer players
Authors: Dugdale James H. , Arthur Calum A. , Sanders Dajo , Hunter Angus M. 
Published: December 2018

ABSTRACTThis study aimed to establish between‐day reliability and validity of commonly used field‐based fitness tests in youth soccer players of varied age and playing standards, and to discriminate between players without (“unidentified”) or with (“identified”) a direct route to professional football through their existing club pathway. Three‐hundred‐and‐seventy‐three Scottish youth soccer players (U11–U17) from three different playing standards (amateur, development, performance) completed a battery of commonly used generic field‐based fitness tests (grip dynamometry, standing broad jump, countermovement vertical jump, 505 (505COD) and T‐Drill (T‐Test) change of direction and 10/20 m sprint tests) on two separate occasions within 7–14 days. The majority of field‐based fitness tests selected within this study proved to be reliable measures of physical performance (ICC = 0.83–0.97; p < .01). However, COD tests showed weaker reliability in younger participants (ICC = 0.57–0.79; p < .01). The field‐based fitness testing battery significantly discriminated between the unidentified and identified players; χ2 (7) = 101.646, p < .001, with 70.2% of players being correctly classified. We have shown field‐based fitness tests to be reliable measures of physical performance in youth soccer players. However, results from the 505COD and T‐Test change of direction tests may be more variable in younger players, potentially due to complex demands of these tests and the limited training age established by these players. While the testing battery selected in this study was able to discriminate between unidentified and identified players, findings were inconsistent when attempting to differentiate between individual playing standards within the “identified” player group (development vs. performance).
Checking for a Narrower Impact of White
Authors: Vande Kamp Garrett N. 
Published: December 2018

AbstractAnalysis of Republican Party of Minnesota v. White by political scientists shows that White had no appreciable effect on the conduct or outcome of judicial elections, including a comprehensive study of White by Chris W. Bonneau, Melinda Gann Hall, and Matthew J. Streb. Yet there is reason to believe that White may have had a more narrow impact than Bonneau, Hall, and Streb originally allowed. An extension of their original analysis is conducted, with results showing that their findings are largely robust to more tailored model specifications. Exceptions include findings on ballot roll-off, but contradictory results further support the notion that White truly had no effect.
MetFlow: an interactive and integrated workflow for metabolomics data cleaning and differential metabolite discovery
Authors: Shen Xiaotao , Zhu Zheng-Jiang 
Published: December 2018

Abstract

Summary
Mass spectrometry-based metabolomics aims to profile the metabolic changes in biological systems and identify differential metabolites related to physiological phenotypes and aberrant activities. However, many confounding factors during data acquisition complicate metabolomics data, which is characterized by high dimensionality, uncertain degrees of missing and zero values, nonlinearity, unwanted variations and non-normality. Therefore, prior to differential metabolite discovery analysis, various types of data cleaning such as batch alignment, missing value imputation, data normalization and scaling are essentially required for data post-processing. Here, we developed an interactive web server, namely, MetFlow, to provide an integrated and comprehensive workflow for metabolomics data cleaning and differential metabolite discovery.

Availability and implementation
The MetFlow is freely available on http://metflow.zhulab.cn/.

Supplementary information
Supplementary data are available at Bioinformatics online.
Clinical Practice Guideline for the Management of Asymptomatic Bacteriuria: 2019 Update by the Infectious Diseases Society of America
Authors: Nicolle Lindsay E , Gupta Kalpana , Bradley Suzanne F , Colgan Richard , DeMuri Gregory P , Drekonja Dimitri , Eckert Linda O , Geerlings Suzanne E , Köves Béla , Hooton Thomas M , Juthani-Mehta Manisha , Knight Shandra L , Saint Sanjay , Schaeffer Anthony J , Trautner Barbara , Wullt Bjorn , Siemieniuk Reed 
Published: December 2018

Abstract
Asymptomatic bacteriuria (ASB) is a common finding in many populations, including healthy women and persons with underlying urologic abnormalities. The 2005 guideline from the Infectious Diseases Society of America recommended that ASB should be screened for and treated only in pregnant women or in an individual prior to undergoing invasive urologic procedures. Treatment was not recommended for healthy women; older women or men; or persons with diabetes, indwelling catheters, or spinal cord injury. The guideline did not address children and some adult populations, including patients with neutropenia, solid organ transplants, and nonurologic surgery. In the years since the publication of the guideline, further information relevant to ASB has become available. In addition, antimicrobial treatment of ASB has been recognized as an important contributor to inappropriate antimicrobial use, which promotes emergence of antimicrobial resistance. The current guideline updates the recommendations of the 2005 guideline, includes new recommendations for populations not previously addressed, and, where relevant, addresses the interpretation of nonlocalizing clinical symptoms in populations with a high prevalence of ASB.
The Expression of agrp1, A Hypothalamic Appetite-Stimulating Neuropeptide, Reveals Hydrodynamic-Induced Starvation in a Larval Fish
Authors: Koch L , Shainer I , Gurevich T , Holzman R 
Published: December 2018

AbstractLarval fish suffer dramatic mortality in the days following transition to autonomous feeding, with over 90% of larvae being eliminated within a period of few weeks. Recent work has shown that the hydrodynamic environment experienced by recently-hatched larvae impedes their feeding rates even under high prey densities. Here, we quantified starvation through early ontogeny in Sparus aurata larvae (8–18 days post-hatching; DPH) and tested whether the emerging ontogenetic pattern is consistent with that expected one based on the hydrodynamic environment that these larvae experience. We screened three candidate genes agrp1, npy, and hsp70, whose expression was previously shown to respond to starvation in fish. Of the three genes, agrp1 was identified as a suitable indicator for starvation. Localization of agrp1 mRNA by whole-mount in-situ hybridization confirmed that, in S. aurata larvae, agrp1 is expressed only in the hypothalamus. Quantification of agrp1 mRNA using real-time PCR revealed that the expression of this gene is elevated in starved compared to fed larvae, and in younger (8 DPH) compared to older larvae (18 DPH). Manipulating the water viscosity to simulate the hydrodynamic conditions during the onset of the critical period led to increased agrp1 expression. These findings suggest that the hydrodynamic constraints on larval feeding lead to the starvation of small larvae. Further, they provide a mechanistic explanation for the “safe harbor” hypothesis, which postulates that larvae should allocate resources toward rapid linear growth to escape detrimental effects of dwelling in an environment where viscous fluid forces dominate.
High-volume surfactant administration using a minimally invasive technique: Experience from a Canadian Neonatal Intensive Care Unit
Authors: Bhattacharya Soume , Read Brooke , McGovern Evelyn , da Silva Orlando 
Published: December 2018

Abstract

Background
Surfactant delivery via a thin endotracheal catheter during spontaneous breathing, a technique called minimally invasive surfactant therapy (MIST), is an alternative to intubation and surfactant administration. There is paucity of data regarding the administration of high-volume surfactant using this technique.

Methods
We conducted a retrospective cohort study to review the safety, efficacy, and procedural details pertaining to the delivery of 5 mL/kg of BLES® via MIST approach. In 2016, our centre initiated a practice change allowing the use of MIST as an alternative method of surfactant delivery in infants born at ≥28 weeks and/or with a birth weight ≥ 1,000 g with respiratory distress syndrome. In this study, we identified all neonates who received surfactant via MIST between May 1, 2016 and July 30, 2018 and collected relevant procedural data.

Results
Since this practice change, MIST technique was attempted in 43 neonates with successful instillation of surfactant in 41 (95.3%) of the neonates. Intubation and positive pressure ventilation was avoided in 35 neonates (85.3%). No serious adverse effect was noted.

Conclusions
Our study reports successful use of higher volume surfactant via MIST. This should encourage other similar centres to consider this technique, in order to avoid unnecessary intubation and positive pressure ventilation.
Naloxone Availability and Pharmacy Staff Knowledge of Standing Order for Naloxone in Pennsylvania Pharmacies
Authors: Graves Rachel L. , Andreyeva Elena , Perrone Jeanmarie , Shofer Frances S. , Merchant Raina M. , Meisel Zachary F. 
Published: December 2018

Objective:
To assess the availability and price of naloxone as well as pharmacy staff knowledge of the standing order for naloxone in Pennsylvania pharmacies.

Methods:
We conducted a telephone audit study from December 2016 to April 2017 in which staff from Pennsylvania pharmacies were surveyed to evaluate naloxone availability, staff understanding of the naloxone standing order, and out-of-pocket cost of naloxone.

Results:
Responses were obtained from 682 of 758 contacted pharmacies (90% response rate). Naloxone was stocked (ie, available for dispensing) in 306 (45%) pharmacies surveyed. Of the 376 (55%) pharmacies that did not stock naloxone, 118 (31%) stated that they could place an order for naloxone for pickup within 1 business day. Responses by pharmacy staff to questions about key components of the standing order for naloxone were collected from 581 of the 682 pharmacies who participated in the survey (85%). Of the 581 pharmacy staff members who stated that they either stocked or could order naloxone, 64% correctly answered all questions pertaining to understanding of the naloxone standing order. The respective median out-of-pocket prices stated in the audit varied by formulation and ranged from $50 to $4000. Staff from national pharmacies were significantly more likely than staff from regional/local chain and non-chain pharmacies to correctly answer that a prescription was not required to obtain naloxone (68.5%, 57.7%, and 52.4% respectively, (P = 0.0045).

Conclusions:
Multiple barriers to naloxone access exist in pharmacies across a large, diverse state, despite the presence of a standing order to facilitate such access. Limited availability of naloxone in pharmacies, lack of knowledge or understanding by pharmacy staff of the standing order, and variability in out-of-pocket cost for this drug are among these potential barriers. Regulatory or legal incentives for pharmacies or drug manufacturers, education efforts directed toward pharmacy staff members, or other interventions may be needed to increase naloxone availability in pharmacies.
A STROBE compliant observational study on trace elements in patients with ulcerative colitis and their relationship with disease activity
Authors: Poursadegh Farid , Ahadi Mitra , Vosoughinia Hassan , Salehi Maryam , Beheshti Namdar Ali , Farzanehfar Mohammad Reza , Memar Bahram , Ziaolhagh Reza 
Published: December 2018

Abstract
Nutritional deficiencies and malnutrition are considered to be related to ulcerative colitis (UC); however, the association between serum levels of micronutrients and UC is not well known. This study aimed to evaluate the serum levels of micronutrients in UC patients and investigate their association with disease activity.
This cross-sectional study was conducted on UC patients visiting the Department of Gastroenterology at 3 different teaching hospitals between January 2016 and January 2017. UC activity was measured based on Truelove and Witts’ severity index and guidelines for colonoscopy. A healthy gender- and age-matched group was also selected. Serum levels of zinc, copper, selenium, ceruloplasmin, albumin, and total protein were compared between the 2 groups of UC patients and healthy subjects using independent-samples t test. Also, the association between serum levels of micronutrients and UC activity was assessed by using Pearson and Spearman correlation coefficient tests. The data were analyzed by SPSS version 21, considering P ≤.05 as the statistical significance level.
Overall, 112 (54 male and 58 female) individuals with the mean age of 34.6 years were studied in the 2 groups of UC patients (n = 56) and healthy subjects (n = 56). The 2 groups were homogeneous in terms of age, gender, marital status, place of residence, and educational level (P >.05). The serum levels of total protein (6.41 ± 1.1 vs 7.41 ± 0.4 g/dL; P = .0001), albumin (4.72 ± 1.1 vs 5.19 ± 0.28 g/dL; P = .0001), zinc (679 ± 62 vs 1055 ± 156 μg/L; P = .0001), and selenium (81.85 ± 6.4 vs 108.4 ± 12.98 micg/L; P = .0001) were significantly lower in the UC patients. The serum level of copper did not differ significantly between the 2 groups (P = .1).
Considering the simultaneous reduction in nutritional criteria in the UC patient group, malnutrition appears to be a factor affecting micronutrient deficiency in patients with UC.
Myiasis-induced sepsis: a rare case report of Wohlfahrtiimonas chitiniclastica and Ignatzschineria indica bacteremia in the continental United States
Authors: Lysaght Travis B. , Wooster Meghan E. , Jenkins Peter C. , Koniaris Leonidas G. 
Published: December 2018

Abstract

Rationale:
The presentation of sepsis and bacteremia in cutaneous and cavitary myiasis is uncommon. We present a patient, residing in a temperate region of the United States, with myiasis and sepsis from the emerging human pathogens Wohlfahrtiimonas chitiniclastica and Ignatzschineria indica.

Patient concerns:
A 37-year-old male patient with an 8-month history of chronic lymphedema and ulcers of the lower left extremity presented with myiasis of the left foot and leg. The patient was initially seen by his family practitioner many times and was prescribed antibiotics which he could not afford. Debridement of the myiasis was not conducted by the family practitioner due to the belief that the patient's current state of myiasis would effectively debride and eventually heal the chronic ulcers along with multiple antibiotic regimens. Over the 8-month period, the patient developed a progressive, painful, necrotizing infection of his lower left extremity.

Diagnoses:
Physical examination clearly showed myiasis of the patient's lower left extremity, believed to be caused by Lucilia sericata (green bottle fly). Blood cultures revealed the presence of Providencia stuartii, W chitiniclastica, and I indica to be the underlying cause of sepsis and bacteremia.

Interventions:
All visible maggots were extracted, debridement of devitalized tissue was performed, and the leg ulcers were wrapped in pH neutral bleach. The patient was initially treated with a broad-spectrum antibiotic regimen of vancomycin, clindamycin, piperacillin, and tazobactam which, following clinical improvement, was de-escalated to cefepime.

Outcomes:
The fly larvae and maggots were removed from the extremity by scrubbing, pulse lavage, and filing away the callused tissue. Additionally, the patient's sepsis and bacteremia, caused by W chitiniclastica and I indica, were successfully treated through antibiotic intervention. Amputation was avoided.

Lessons:
The use of pulse lavage and chlorhexidine-soaked brushes for the removal of cavitary myiasis is an effective and minimally invasive procedure which does not cause additional damage to surrounding tissue. W chitiniclastica and I indica are emerging bacteria that have known association to parasitic fly myiasis in humans and are capable of causing sepsis and/or bacteremia if not accurately identified and treated promptly.
Comparison of refractive outcomes between femtosecond laser-assisted cataract surgery and conventional cataract surgery
Authors: Whang Woong-Joo , Yoo Young-Sik , Joo Choun-Ki , Yoon Geunyoung 
Published: December 2018

Abstract
The purpose of our study is to compare the predictive accuracy of femtosecond laser-assisted cataract surgery with the results of conventional cataract surgery. This prospective study included 83 eyes from 83 patients who underwent femtosecond laser-assisted cataract surgery and 83 eyes from 83 patients who underwent conventional cataract surgery. Preoperative IOL power calculations were performed with the partical coherence interferometry. Femtosecond laser-assisted capsulotomy was based on 5.2 mm scanned capsule center. Following phacoemulsification, 1-piece IOL was inserted into the capsular bag. Refractive outcome was measured 3 months postoperatively with manual refraction. Predicted refraction was assessed by the Barret-Universal II, Haigis, Hoffer Q, SRK/T, and T2 formulas. We applied optimized IOL constants and retrospectively personalized IOL constants. There was no difference in preoperative demographic data. When the optimized IOL constants were used, the femtosecond laser-assisted group produced significantly lower MAEs in the Barret-Universal II, Hoffer Q, SRK/T, and T2 formulas (P < .05). After the personalization of IOL constants, there were statistical differences in the Barret-Universal II, Hoffer Q (P < .05). The standard deviation of ME and MedAE were also relatively lower with femtosecond laser-assisted group. In conclusion, femtosecond laser-assisted cataract surgery with Catalys femtosecond laser system produced better refractive outcomes than conventional cataract surgery.
Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia
Authors: Jin Linfang , Wang Zhiqiang , Qi Xiaowei 
Published: December 2018

Abstract

Rationale:
Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia (DIPNECH) is a rare idiopathic disease with only about 100 cases reported in the literature.

Patient concerns:
Here, we presented 4 cases of DIPNECH. Four patients included 2 females and 2 males, aged 54 to 64 years old; 3 had no smoking history and 1 had history of smoking for 30 years. Surgical resection was performed for every patient. Cases 1 and 3 did not receive postoperative chemotherapy or radiotherapy, and case 2 received 4 times of postoperative chemotherapy. Case 4 just finished the operation and after a period of time, he will receive postoperative chemotherapy.

Diagnoses:
Case 1: A 57-year-old female had chest pain, and computer tomography (CT) examination prompted a mass shadow of left lung lower lobe. Case 2: A 64-year-old female had cough and expectoration for more than 1 month. CT examination showed: a lump with diameter of about 2.5 cm and irregular edge was in right lung upper lobe, being largely possibly lung cancer. Case 3: A 54-year-old male, CT examination accidentally found a long strip-shaped nodule in left lung oblique fissure when checkup's, and he had no fever, cough, expectoration, chest tightness, or chest pain. Case 4: A 61-year-old male, checkup's CT examination accidentally found a nodule, fibrosis, bronchiectasis, and secondary infection in the left lower lobe. Combined with pathological morphology and immunohistochemistry, cases 1 and 3 were diagnosed as DIPNECH with multiple carcinoid tumorlet formation and chronic inflammation and bronchiectasis, case 2 was diagnosed as an adenocarcinoma with DIPNECH and multiple carcinoid tumorlet formation, case 4 was diagnosed as an adenocarcinoma with DIPNECH and multiple carcinoid tumorlet formation and chronic inflammation and bronchiectasis.

Interventions:
Surgical resection was performed for every patient. Cases 1 and 3 did not receive postoperative chemotherapy or radiotherapy, and case 2 received 4 times of postoperative chemotherapy. Case 4 just finished the operation and after a period of time, he will receive postoperative chemotherapy.

Outcomes:
Four patients have been followed up and have had good condition.

Lessons:
DIPNECH is often found accidentally in a surgical specimen, is easily missed, and needs careful observation. Immunohistochemistry is necessary to make this diagnosis.