bluuebunny/crossref_metadata_2025_split huggingface dataset:
Long non‐coding RNA GAPLINC promotes angiogenesis by regulating miR‐211 under hypoxia in human umbilical vein endothelial cells
Authors: He Yangyan , Wu Ziheng , Qiu Chenyang , Wang Xiaohui , Xiang Yilang , Lu Tian , He Yunjun , Shang Tao , Zhu Qianqian , Wang Xun , Zeng Qinglong , Zhang Hongkun , Li Donglin 
Published: October 2019

AbstractIn this study, we investigated the role of a long non‐coding RNA GAPLINC in angiogenesis using human umbilical vein endothelial cells (HUVEC). We found that hypoxia and hypoxia‐inducible factor 1α (HIF‐1α) increased the expression of GAPLINC in HUVEC cells. Moreover, GAPLINC overexpression down‐regulated miR‐211 and up‐regulated Bcl2 protein expression. Further rescue experiments confirmed that hypoxia directly increased GAPLINC expression. GAPLINC overexpression also increased cell migration and vessel formation which promoted angiogenesis, and these changes were attributed to the increased expression of vascular endothelial growth factor receptors (VEGFR) and delta‐like canonical notch ligand 4 (DLL4) receptors. Finally, we demonstrated that GAPLINC promotes vessel formation and migration by regulating MAPK and NF‐kB signalling pathways. Taken together, these findings comprehensively demonstrate that overexpression of GAPLINC increases HUVEC cells angiogenesis under hypoxia condition suggesting that GAPLINC can be a potential target for critical limb ischaemia (CLI) treatment.
Optimizing isolation process of kaempferitrin from leaves of Prunus cerasifera
Authors: Wu Bo , Peng Lijuan , Yang Guoyan 
Published: October 2019

AbstractKaempferitrin was extracted from leaves of Prunus cerasifera with an average yield of 1.3 ± 0.18% (n = 20). The purity of the product was over 98.5% as determined by high‐performance liquid chromatography. Dried and smashed leaves of P. cerasifera were subjected to extraction with 70% ethanol (vol/vol) at room temperature and the extract was concentrated by vacuum evaporation. The extract was separated using nonpolar and medium polar macroporous resin in series. The post‐column collecting solution was concentrated under reduced pressure and its product was obtained through secondary crystallization. Kaempferitrin obtained was structurally analyzed and characterized. The absorption of kaempferitrin to macroporous resin was analyzed thermodynamically and kinetically to determine its melting and turbidity point. After purification of mother liquor, the recovery rate was over 70%.Practical ApplicationsPrunus cerasifera is a plant resource that has yet to be tapped. Kaempferitrin in its leaves, with a content of 1.8–2.2%, is an important bioactive substance. Pharmacologically, kaempferitrin induces immune reactions in vitro, stimulates the secretion of adiponectin in adipocytes, elicits apoptosis, and possess antitumor effects. Separation of kaempferitrin from P. cerasifera leaves using the macroporous resin double‐column system is cost‐effective and simple. Moreover, the method can achieve high extraction efficiency. After crystallization, the purity was higher than 98.5%. The technology can be widely used in the preparation processes of medical agents. In addition, the results showed that the optimized parameters can be applied to the parameter prediction of related designs.
Optimal antibribery policy when bribery type is endogenous
Authors: Hong Fuhai , Yin Zhendong 
Published: October 2019

AbstractThis paper analyzes the optimal allocation of antibribery resources when bribery type is endogenously determined by corrupt bureaucrats. A firm is supposed to invest to get licenses for production from bureaucrats. The bureaucrat commits to a bribes schedule that specifies bribes demanded from compliant firms (therefore, engaging in extortion) and noncompliant firms (engaging in collusion) as a precondition of granting the license. The allocation of antibribery resources determines the probability that each type of bribery is detected and prosecuted and thus affects the bureaucrat's choice of bribes schedule and the equilibrium bribery type. We find that the government should prioritize combating collusion when the resources are sufficiently scarce, should abstain from combating extortion after it wipes out collusion when the resources are less scarce, and should eradicate both types of bribery when the resources are sufficiently abundant. When there are multiple investment dimensions, however, there exists a special case where the government targets both types of bribery when the resources are at some intermediate level.
Hyperspectral imaging of drill core from the Steen River impact structure, Canada: Implications for hydrothermal activity and formation of suevite‐like breccias
Authors: MacLagan E. A. , Walton E. L. , Herd C. D. K. , Rivard B. 
Published: October 2019

AbstractHyperspectral imaging can be used to rapidly identify and map the spatial distributions of many minerals. Here, hyperspectral mapping in three wavelength regions (visible and near‐infrared, shortwave infrared, and thermal infrared) was applied to drill cores (ST001, ST002, and ST003) penetrating a continuous sequence of crater‐fill breccias from the Steen River impact structure in Alberta, Canada. The combined data sets reveal distinct mineralogical layering, with breccias derived predominantly from sedimentary rocks overlying those derived from granitic basement. This stratigraphy demonstrates that the breccias were not appreciably disturbed following deposition, which is inconsistent with formation models of similar breccias (suevites) by explosive impact melt–fluid interaction. At Steen River, volatiles from sedimentary target rocks were an inherent part of forming these enigmatic breccias. Approximately three quarters of terrestrial impact structures contain sedimentary target rocks; therefore, the role of volatiles in producing so‐called suevitic breccias may be more widespread than previously realized. The hyperspectral maps, specifically within the SWIR wavelength region, also delineate minerals associated with postimpact hydrothermal activity, including ammoniated clay and feldspar minerals not detectable using traditional techniques. These nitrogen‐bearing minerals may have originated from microbial processes, associated with oil‐ and gas‐producing units in the crater vicinity. Such minerals may have important implications for the production of habitable environments by impact‐induced hydrothermal activity on Earth and Mars.
Sedimentological analysis of two drill cores through the crater moat‐filling breccia, Flynn Creek impact structure, Tennessee
Authors: De Marchi L. , Ormö J. , King D. T. , Adrian D. R. , Hagerty J. J. , Gaither T. A. 
Published: October 2019

AbstractSedimentological (line‐logging) analysis of two drill cores, FC77‐3 and FC67‐3, situated, respectively, in the northwestern and southeastern quadrants of the Flynn Creek impact structure's crater‐moat area reveals that the ~27 m thick crater moat‐filling breccia consists of three subequal parts. These parts, which were deposited during early modification stage of this marine‐target impact structure, are distinguished on the basis of vertical trends in sorting, grain size, and counts of clasts per meter in comparison with other well‐known marine‐target impact structures, namely Lockne, Tvären, and Chesapeake Bay. The lower part is interpreted to represent mainly slump deposits, and the middle part is interpreted to represent a stage intermediate between slump and marine resurge, that is, a traction flow driven by overriding suspension flow. The upper part (size graded, and relatively well sorted and fine grained) is interpreted to represent marine resurge flow only. The upper part is capped by a relatively thin and relatively fine‐grained calcarenite to calcisiltite deposit.
Certified nursing assistants as agents of creative caregiving in long‐term care
Authors: Eaton Jacqueline , Cloyes Kristin , Paulsen Brooke , Madden Connie , Ellington Lee 
Published: October 2019

AbstractAimCertified nursing assistants (CNAs) provide most of the direct care for long‐term care (LTC) residents, yet there are few CNA‐led interventions aimed at improving quality of care. In our preliminary work developing a CNA art‐based intervention, we describe CNA definitions and perceptions of creativity in relation to care of LTC residents.MethodsData from six sequential focus groups with CNAs (n = 14) in two LTC facilities were analysed to describe the concept of creativity in relation to LTC caregiving and its meaning to CNAs working in LTC.ResultsCertified nursing assistants defined creativity as formal art‐making, yet they also described creative approaches to engaging residents in order to build relationships and reduce challenging behaviour. While most linked creativity with discerning and responding to resident needs, creativity was also foundational to time management, teamwork and navigating challenges.ConclusionDeveloping CNA‐centred interventions to promote creative caregiving may enhance both person‐centred LTC and CNA empowerment, improving resident care.Implications for practiceCNA creativity should be viewed as a skill with the potential to enhance care and increase CNA empowerment. Interventions should be developed, in partnership with CNAs, to promote creative caregiving.
Skin microbiota: Friend or foe in pediatric skin health and skin disease
Authors: Schneider Andrea M. , Nelson Amanda M. 
Published: October 2019

AbstractThe human integument and gastrointestinal tract host unique microbial ecosystems. Within the last decade, research has focused on understanding the contributions of the microbiota to human health and disease. The majority of skin microbiome studies involve adults. This review focuses on key studies conducted within the pediatric population and provides a framework for future skin microbiome work in this ever‐expanding field. This article begins by exploring the skin microbiome at birth and reviews the impact of delivery mode on infant skin colonization. How skin microbial colonization evolves from infancy to adulthood and normal development impacts the abundance of skin commensals such as Streptococcus, Staphylococcus, and Cutibacterium is also highlighted. Finally, several skin microbiome research studies in common pediatric skin conditions are reviewed, including body odor, atopic dermatitis (AD), and acne. The bacteria involved in metabolizing sweat, the impact on body odor, and how this process evolves from childhood to adulthood is outlined. In AD, different bacteria genera that predominate in children and adults and the impact of current AD therapies on skin microbiota are explored. Finally, in acne, the understanding of how Cutibacterium acnes contributes to acne pathogenesis and how acne therapies impact the skin microbial communities is reviewed.
Severe recurrent aphthous stomatitis treated with adalimumab: A case report in a teenage patient
Authors: de Perosanz‐Lobo Dario , Latour Irene , Ortega‐Quijano Daniel , Fernández‐Guarino Montserrat , Torrelo Antonio 
Published: October 2019

AbstractRecurrent aphthous stomatitis (RAS) is a chronic disorder of unknown etiology characterized by recurring ulcers involving the oral mucosa in patients with no other manifestations. It is a common cause of oral ulcers in children. In its major form, RAS can be a severe and disabling disorder due to pain and scarring, and poses a therapeutic challenge. Therapies for major RAS include prednisone, thalidomide, colchicine, and dapsone. However, many patients do not achieve adequate control of the disease with them (J Clin Diagn Res, 10, 2016 and ZE08). We report a case of severe RAS in a teenager with a dramatic response to adalimumab.
Get in line: Do part‐time legislatures use sunset laws to keep executive agencies in check
Authors: Baugus Brian , Bose Feler , Jacob Jeffry 
Published: October 2019

AbstractSunset provisions are clauses embedded in legislation that cause a piece of legislation or a regulatory board to expire on a certain date unless the legislature takes affirmative action to renew the legislation or board. Supporters and legislators offer several reasons why sunset laws are valuable and useful. An article by Baugus and Bose (2015), reported on the king‐and‐council model of Congleton (2001), suggests that sunset laws are a key tool legislatures use in asserting themselves against an executive branch that often dominates state government. We investigate this possibility using empirical analysis, which suggests that part‐time legislatures, specifically, a form of part‐time legislature referred to as hybrid legislatures, are more prone to use sunset legislation as a tool to keep the executive preferences in check.
Producing knowledge about mercury mining: Local practices and textual tools
Authors: Raphael Renée 
Published: October 2019

AbstractThis contribution analyses accounts of the refining of mercury in the printed works of Biringuccio, Agricola, and Barba and in archival documents related to mercury production at Almadén. Similarities in printed texts, coupled with the lack of connections of their authors to significant sites of mercury mining in the early modern world, suggest that these authors developed their accounts not through personal experience or knowledge exchanges with practitioners but through the types of textual borrowings associated with period humanist scholarship. Examination of local archival sources produced at Almadén indicates, moreover, the lack of correspondence between these printed accounts and local practices at the foremost site of mercury production in early modern Europe. These findings indicate the continuing importance of textual forms of scholarship in the production of period technical knowledge and the dangers of using such learned treatises as indicators of actual practice.
Pragmatic and (or) Constitutive? On the Foundations of Contemporary Risk Communication Research
Authors: Rickard Laura N. 
Published: October 2019

AbstractA diffuse and interdisciplinary field, risk communication research, is founded on how we understand the process and purpose of communication more generally. To that end, this article outlines two fundamental functions of risk communication: (1) a pragmatic function, in which senders direct messages at audiences (and vice versa), with various intended (and sometimes unintended) effects; and (2) a constitutive function, in which messages re(create) what we mean by “risk” in a given social context, including how we can, and/or should relate to it. Although representing distinct epistemological and theoretical social scientific traditions, these functions necessarily coexist in a broader understanding of risk communication, including its so‐called “effectiveness.” The article concludes by considering how we might enact this fuller understanding of risk communication's dual functions through engagement in collaborative, sustainability science‐oriented research.
Exploiting autoimmunity unleashed by low‐dose immune checkpoint blockade to treat advanced cancer
Authors: Bakacs Tibor , Moss Ralph W. , Kleef Ralf , Szasz Marcell A. , Anderson Colin C. 
Published: October 2019

AbstractAs a result of the cancer immunotherapy revolution, more than 2000 immuno‐oncology agents are currently being tested or are in use to improve responses. Not unexpectedly, the 2018 Nobel Prize in Physiology or Medicine was awarded to James P. Allison and Tasuku Honjo for their development of cancer therapy by the blockade of co‐inhibitory signals. Unfortunately, manipulation of the co‐inhibitory receptors has also resulted in a safety issue: widespread iatrogenic immune‐related adverse events (irAEs). Autoimmunity is emerging as the nemesis of immunotherapy. Originally, it was assumed that CTLA‐4 blockade selectively targets T cells relevant to the antitumour immune response. However, an uncontrolled pan T cell activation was induced compromising tolerance to healthy self‐tissues. The irAEs are very similar to that of a chronic graft‐versus‐host‐disease (GVHD) reaction following allogeneic bone marrow transplantation (BMT). We hypothesized that ipilimumab induced a graft‐versus‐malignancy (GVM) effect, which eradicated metastatic melanoma in a minority of patients, but also involved an auto‐GVHD reaction that resulted in widespread autoimmunity in the majority. Therefore, we argued for a profound theoretical point against the consensus of experts. The task is not to desperately put the genie back in the bottle by immune‐suppressive treatments, but instead to harness the autoimmune forces. In this way, the same goal could be achieved by an antibody as by the adoptive transfer of alloreactive donor lymphocytes, but without severe GVHD. The proof‐of‐principle of a low‐dose‐combination immune checkpoint therapy, consisting only of approved drugs and treatments, was demonstrated in 111 stage IV cancer patients.
Smart devices for the management of pediatric asthma: a scoping review protocol
Authors: Betz Cecily L. , Lewinter Katherine , Kysh Lynn , Hudson Sharon , Espinoza Juan 
Published: October 2019

ABSTRACT

Objective:
The objective of this scoping review is to identify the scope of literature published on the use of smart devices for interventions in pediatric asthma, including low income and culturally diverse populations.

Introduction:
Childhood asthma results in substantial morbidity and costs that pose a significant burden to families and healthcare systems. Low-income and culturally diverse pediatric populations have increased rates of morbidity and mortality compared to higher income families. Smart devices have the potential to improve pediatric asthma health outcomes and reduce health disparities.

Inclusion criteria:
This scoping review will consider studies with participants who are children, adolescents and young adults with the diagnosis of asthma (ages zero to 26 years). Studies of children and adolescents and young adults with asthma may include adult participants who manage and/or supervise asthma care or provide asthma instruction.

Methods:
This scoping review will be conducted using the Ovid MEDLINE, Embase, Cochrane Library, CINAHL, Web of Science, PsycINFO, ERIC, and both Compendex and Inspec through Engineering Village databases. Gray literature searches will also be conducted. Studies will be reviewed independently by two reviewers, with any conflicts adjudicated by a third member. Data extracted will be presented in a tabular format with an accompanying narrative.
Accelerating Clinical Innovation in Biomedical Engineering Education by Using a Digital Portal for Collaboration
Authors: Berry Joel L. , Noles Kristen , Eberhardt Alan , Wingo Nancy 
Published: October 2019

Abstract
The rapidly changing healthcare landscape requires continuous innovation by clinicians, yet generating ideas to improve patient care is often problematic. This paper describes the development of a digital tool used in an interprofessional program designed to enhance collaborations between clinicians, undergraduate, and graduate STEM students, particularly biomedical engineering (BME). The program founders began by connecting clinicians and students through a course portal in a learning management system (LMS). They eventually secured internal funding to create an open access tool for posting and viewing problems, allowing interprofessional teams to rally around healthcare challenges and create prototypes for solving them. Results after three years of the program's inception have been encouraging, as teams have created devices and processes that have led to intellectual property disclosures, provisional patents, grant funding, and other productive interprofessional relationships. The open access tool has given clinicians and STEM students an outlet for convenient team formation around unsolved clinical problems and allowed a fluid exchange of ideas between participants across a variety of clinical disciplines.
Modeling of Top Burr Formation in Micro-End Milling of Zr-Based Bulk Metallic Glass
Authors: Ray Debajyoti , Puri Asit Baran , Hanumaiah Naga , Halder Saurav 
Published: October 2019

Abstract
In this study, an analysis is presented for the formulation of a model in top burr formation to estimate the width of the top burrs formed in micro-end milling process. In this analysis, the width of the top burrs, considered to be the measure of burr size of top burrs, represents the extent of burr formation. The model is applied to quantify the burr formation in Zr-based bulk metallic glass, an amorphous metallic alloy. In this study, micromilling experiments were carried out on the bulk metallic glass work material at different levels of feed rate, axial depth of cut, and cutting speed to compare the experimental values of top burr width with the predicted values. Analysis is carried out to characterize top burr formation based on the experimental results of burr sizes in the up-milling and down-milling side edges, and the influential effects of the cutting parameters on the burr formation are analyzed.
Exact decoherence brought by one internal degree of freedom: von Neumann equation approach and examples
Authors: Besagas John Paul A. , Lima Jan Carlo L. , Galapon Eric A. 
Published: October 2019

In a quantum measurement setting, it is known that environment-induced decoherence theory describes the emergence of effectively classical features of the quantum system–measuring apparatus composite system when the apparatus is allowed to interact with the environment. In [E. A. Galapon, Europhys. Lett. 113, 60007 (2016)], a measurement model is found to have the feature of inducing exact decoherence at a finite time via one internal degree of freedom of the apparatus provided that the apparatus is decomposed into a pointer and an inaccessible probe, with the pointer and the probe being in momentum-limited initial states. However, an issue can be raised against the model: while the factorization method of the time-evolution operator used there is formally correct, it is not completely rigorous due to some unstated conditions on the validity of the factorization in the Hilbert space of the model. Furthermore, no examples were presented there in implementing the measurement scheme in specific quantum systems. The goal of this paper is to re-examine the model and confirm its features independently by solving the von Neumann equation for the joint state of the composite system as a function of time. This approach reproduces the joint state obtained in the original work, leading to the same conditions for exact decoherence and orthogonal pointer states when the required initial conditions on the probe and pointer are imposed. We illustrate the exact decoherence process in the measurement of observables of a spin-1/2 particle and a quantum harmonic oscillator by using the model.
A short note on inverse sum indeg index of graphs
Authors: Balachandran Selvaraj , Elumalai Suresh , Mansour Toufik 
Published: October 2019

The inverse sum indeg index of a graph [Formula: see text] is defined as [Formula: see text], where [Formula: see text] is the degree of the vertex [Formula: see text]. In a recent paper, Pattabiraman [Inverse sum indeg index of graphs, AKCE Int. J. Graphs Combinat. 15(2) (2018) 155–167] gave some lower and upper bounds on [Formula: see text] index of all connected graphs in terms of Harmonic index, second Zagreb index and hyper Zagreb index. But some results were erroneous. In this note, we have corrected these results.