bluuebunny/crossref_metadata_2025_split huggingface dataset:
Social media marketing and customers’ passion for brands
Authors: Mukherjee Kaustav 
Published: October 2019

PurposeThe modern-day digital marketers use social media as a tool for brand awareness and customer engagement. However, whether social media marketing can actually impact deeper into the users’ emotional level and instigate purchase intention is a popular moot point. The purpose of this paper is to investigate as to whether social media marketing is effective in inciting a sense of arousal or passion for the advertised brands and finally generate a purchase intention in the minds of the social media users.Design/methodology/approachA convenient sampling procedure was followed to collect relevant data using a structured questionnaire. The technique of structural equation modelling was used for model building using the software, AMOS 18.FindingsThe study reveals that efficient use of social media for marketing communications can generate a passion for the advertised brands in the social media users’ minds, as well as instigate a brand purchase intention.Research limitations/implicationsThe study has been restricted to Indian smartphone customers who also spend a substantial amount of time on social media.Practical implicationsThe use of social media for online customer engagement is a smart strategy that can be employed by digital marketers in order to emotionally connect the advertised brand with the users of social media.Originality/valueThis study is probably the first to investigate the direct impact of social media marketing on users’ brand passion.
How qualitative research can infuse teaching in accounting
Authors: Jack Lisa , Saulpic Olivier 
Published: October 2019

Purpose
This paper aims to present an understanding of what it means to infuse teaching with qualitative research and to introduce the papers in the special issue.

Design/methodology/approach
This is an introductory essay that provides a brief overview and analysis of the ideas to be found in the issue.

Findings
The special issue contributes to the understanding of the integration of teaching and research by showing how the authors as actors, as teacher-researchers, bring not just the findings but also reflexivity into the classroom and take knowledge out into both research and teaching. The papers in this issue all consider the agency of teachers in bringing an epistemology into the classroom, and in developing that epistemology.

Originality/value
The papers in this issue go beyond concepts of research-led teaching and the research-teaching nexus towards reflective pieces that develop understanding of epistemology rather than more conventional reports of classroom interventions.
Sustainable tourism certification, local governance and management in dealing with overtourism in East Africa
Authors: Maingi Shem Wambugu 
Published: October 2019

PurposeThe purpose of this paper is to understand the causes and effects of overtourism within the East African region. The paper examines how national governments address the problem of overtourism in East Africa and determines underlying principles and best practice in sustainable tourism certification, local governance and management in dealing with overtourism.Design/methodology/approachTo address the objectives, the researcher conducted an exploratory experience survey research design. The study examines the different articles in the subject area and interview findings of practitioner respondents. Based on a review of the existing dimensions of overtourism, the effects of overtourism and local governance, the study sought to derive a holistic (systemic and integrated) perspective on the subject matter.FindingsThe paper presents valuable evidence from industry practitioners on the effects of overtourism in East Africa by classifying the effects as psychological, physical, economic and socio-cultural. Further, the paper examines how East African governments address the problem of overtourism and gives recommendations on ways to enforce, govern and coordinate implementation of tourism regulations and policies in East Africa.Originality/valueThis paper is the first to address overtourism in the context of East Africa, examining different local and innovative approaches to dealing with the impacts of overtourism in an East African context.
Speech and language therapists’ reflections on developing and maintaining confidence in tracheoesophageal speech rehabilitation
Authors: Hancock Kelli L. , Ward Elizabeth C. , Hill Anne E. 
Published: October 2019

AbstractBackgroundThe management of tracheoesophageal speech (TES) rehabilitation is an area of speech and language therapists’ (SLTs) clinical practice where knowledge and skills are primarily developed through postgraduate workplace experience and training. Although recent research suggests clinicians in Australia perceive there is adequate access to workplace training, little is known about how clinicians develop and/or maintain clinical confidence when working in this specialist caseload.AimsTo investigate factors that contribute to development of clinician confidence as well as the factors that impact on improving and maintaining confidence when working in the clinical area of TES rehabilitation.Methods & ProceduresSLTs working in an Australian clinical service and in a current or recent caseload including patients using TES were eligible to participate. A total of 36 SLTs were recruited and then grouped by level of experience (novice n = 15, intermediate n = 7, experienced n = 14). Ten focus groups of 60‐min duration were conducted each with three to four participants from the same experience level. A semi‐structured interview guide was used to facilitate the discussion of issues relating to training and confidence; however, only the content pertaining to clinical confidence is reported. Thematic analysis was used to analyse the transcripts.Outcomes & ResultsFour themes were identified as contributing to the development of confidence: training, exposure, accessing support and mentorship, and leadership opportunities. Three themes were identified as critical for improving or maintaining clinical confidence: ongoing management of a caseload, ongoing support and further learning. An additional overarching theme was the desire for SLTs to classify or quantify their level of confidence, typically using a numeric scale or in years of clinical experience. The impact of varying contexts and caseloads on confidence levels was highlighted by all participants, but particularly those in the novice focus groups.Conclusions & ImplicationsThe findings highlight the fact that the acquisition and maintenance of confidence is an ongoing consideration for SLTs, both those starting out and those with years of clinical experience. With patient presentation increasing in complexity, the importance of understanding contributing factors for gaining and maintaining confidence should be considered alongside postgraduate training and the provision of ongoing support for SLTs working in this specialized clinical area, regardless of experience level.
Hydroxychloroquine in dermatology: New perspectives on an old drug
Authors: Chew Christopher Y , Mar Adrian , Nikpour Mandana , Saracino Amanda M 
Published: October 2019

AbstractHydroxychloroquine is an age‐old drug whose use as an immunomodulatory agent with a low side‐effect profile continues to expand. We present a review of this drug including recently updated prescribing recommendations and a summary of its clinical application in dermatology. A maximum daily dose of 5.0 mg/kg based on actual body weight and no greater than 400 mg is advised in order to reduce the risk of retinopathy, which is potentially permanent and has an estimated prevalence of 7.5% at 5 years on standard dosing. Baseline ophthalmologic assessment followed by annual screening after 5 years is recommended; however, closer monitoring should be considered in the setting of existing retinopathy, a cumulative dose > 1000 g or renal dysfunction. Hydroxychloroquine is now considered to be safe in pregnancy, and routine glucose‐6‐phosphate dehydrogenase (G6PD) deficiency testing is not required. Smoking can significantly decrease its efficacy although the reason is still uncertain. Hydroxychloroquine appears to also demonstrate antineoplastic and cardioprotective benefits.
Patients aged less than 3 years with acute myeloid leukaemia characterize a molecularly and clinically distinct subgroup
Authors: Hara Yusuke , Shiba Norio , Yamato Genki , Ohki Kentaro , Tabuchi Ken , Sotomatsu Manabu , Tomizawa Daisuke , Kinoshita Akitoshi , Arakawa Hirokazu , Saito Akiko M. , Kiyokawa Nobutaka , Tawa Akio , Horibe Keizo , Taga Takashi , Adachi Souichi , Taki Tomohiko , Hayashi Yasuhide 
Published: October 2019

SummaryAlthough infants (age <1 year) with acute myeloid leukaemia (AML) have unique characteristics and are vulnerable to chemotherapy, children aged 1–2 years with AML may have characteristics similar to that of infants. Thus, we analysed 723 paediatric AML patients treated on the Japanese AML99 and AML‐05 trials to identify characteristics of younger children. We identified patients aged <3 years (the younger group) as a distinct subgroup. KMT2A‐rearrangement (KMT2A‐R), CBFA2T3‐GLIS2, CBFB‐MYH11 and NUP98‐KDM5A were frequently found in the younger group. Prognostic analyses revealed poor 5‐year overall survival (OS), event‐free survival (EFS) and cumulative incidence of relapse (CIR) in patients with CBFA2T3‐GLIS2 (42%, 17% and 83%, respectively) and those with NUP98‐KDM5A (33%, 17% and 83%, respectively). Additionally, we identified KMT2A‐R and CBFB‐MYH11 as age‐specific prognostic markers. Regarding KMT2A‐R, the younger group had significantly better OS, EFS and CIR than the older group (aged 3 to <18 years) (P = 0·023, 0·011 and <0·001, respectively). Conversely, concerning CBFB‐MYH11, the younger group had significantly poor EFS and CIR than the older group (each P < 0·001), suggesting that certain molecular markers are linked to different prognoses according to age. Therefore, we characterized patients <3 years as a distinct subgroup of paediatric AML.
The effect of glucocorticoids on Thrombospondin‐1, Osteocalcin and the Thrombospondin‐1:Osteocalcin ratio in humans
Authors: Cesana‐Nigro Nicole , Keshvari Sahar , Barclay Johanna L. , Sorbello Jane , Upham John W. , Benham Helen , Anderson Stephen T. , Steiger Natasha , Prins Johannes B. , Inder Warrick J. 
Published: October 2019

AbstractObjectiveThrombospondin‐1 (TSP1), a matricellular protein, and Osteocalcin (OCN), a noncollagenous protein secreted by osteoblasts, are known to be up‐ and down‐regulated, respectively, by glucocorticoids. The aim of this study was to determine whether a ratio between TSP1:OCN was altered by changes in glucocorticoid activity in humans.DesignProspective observational study.SettingTertiary university hospital in Queensland, Australia.Patients and MeasurementsPatients with Cushing's syndrome (CS, n = 19), asthma or giant cell arteritis on chronic prednisolone treatment (PRED, n = 13), adrenal insufficiency (AI, n = 16) and healthy volunteers (HV, n = 20). Plasma TSP1 and serum total OCN were measured by immunoassay at 0800h, 1200h and 1600h in patients with CS, patients with AI taking replacement glucocorticoids, HV before and after 4 mg dexamethasone and PRED patients predose at 800 and 4 hours post‐dose at 1200 hours.ResultsPlasma TSP1 in CS was higher (P < .0001), and serum OCN was lower (P < .0001) than HV. The TSP1:OCN ratio in HV increased significantly after 4 mg dexamethasone (P < .0001) and in AI after taking their hydrocortisone replacement therapy (P < .001). PRED patients had a higher TSP1:OCN ratio compared with HV at both 800 and 1200 hours (both P < .001), but no significant change occurred from pre‐ to post‐dose. A TSP1:OCN ratio of >73 at 800 hours differentiated CS from HV with a sensitivity of 95% and a specificity of 100%.ConclusionsThe TSP1:OCN ratio is elevated in patients on prednisolone and in patients with CS compared with healthy volunteers. It may be a useful biomarker of total body glucocorticoid activity in humans.
Nicotine smoking concentrations modulate GABAergic synaptic transmission in murine medial prefrontal cortex by activation of α7* and β2* nicotinic receptors
Authors: Cuevas‐Olguin Roberto , Esquivel‐Rendon Eric , Vargas‐Mireles Jorge , Barajas‐Lόpez Carlos , Salgado‐Delgado Roberto , Saderi Nadia , Arias Hugo R. , Atzori Marco , Miranda‐Morales Marcela 
Published: October 2019

AbstractNicotine is the major addictive component of cigarettes, reaching a brain concentration of ~300 nM during smoking of a single cigarette. The prefrontal cortex (PFC) mechanisms underlying temporary changes of working memory during smoking are incompletely understood. Here, we investigated whether 300 nM nicotine modulates γ‐aminobutyric acid (GABA) ergic synaptic transmission from pyramidal neurons of the output layer (V) of the murine medial PFC. We used patch clamp in vitro recording from C57BL/6 mice in the whole‐cell configuration to investigate the effect of nicotine on pharmacologically isolated GABAergic postsynaptic currents (IPSCs) in the absence or presence of methyllycaconitine (MLA) or dihydro‐β‐erythroidine (DHβE), selective antagonists of α7‐ and β2‐containing (α7* and β2*) nicotinic acetylcholine receptors (AChRs), respectively. Our results indicated that nicotine, alone or in the presence of MLA, decreases electrically evoked IPSC (eIPSC) amplitude, whereas in the presence of DHβE, nicotine elicited either an eIPSCs amplitude increase or a decrease. In the presence of DHβE, nicotine increased membrane conductance leaving the paired pulse ratio unchanged in all conditions, suggesting a non‐β2* mediated effect. In the presence of MLA, nicotine decreased the mean spontaneous IPSC (sIPSC) frequency but increased their rise time, suggesting a non‐α7* AChR‐mediated synaptic modulation. Also, in the presence of DHβE, nicotine decreased both eIPSC rise and decay times. No receptors other than α7* and β2* appear to be involved in the nicotine effect. Our results indicate that nicotine smoking concentrations modulate GABAergic synaptic currents through mixed pre‐ and post‐synaptic mechanisms by activation of α7* and β2* AChRs.
Characterising extinction debt following habitat fragmentation using neutral theory
Authors: Thompson Samuel E. D. , Chisholm Ryan A. , Rosindell James 
Published: October 2019

AbstractHabitat loss leads to species extinctions, both immediately and over the long term as ‘extinction debt’ is repaid. The same quantity of habitat can be lost in different spatial patterns with varying habitat fragmentation. How this translates to species loss remains an open problem requiring an understanding of the interplay between community dynamics and habitat structure across temporal and spatial scales. Here we develop formulas that characterise extinction debt in a spatial neutral model after habitat loss and fragmentation. Central to our formulas are two new metrics, which depend on properties of the taxa and landscape: ‘effective area’, measuring the remaining number of individuals and ‘effective connectivity’, measuring individuals’ ability to disperse through fragmented habitat. This formalises the conventional wisdom that habitat area and habitat connectivity are the two critical requirements for long‐term preservation of biodiversity. Our approach suggests that mechanistic fragmentation metrics help resolve debates about fragmentation and species loss.
Patient and public involvement in doctoral research: Impact, resources and recommendations
Authors: Coupe Nia , Mathieson Amy 
Published: October 2019

AbstractBackground and aimPatient and public involvement (PPI) has potential to enhance health‐care research and is increasingly an expectation, particularly for many funding bodies. However, PPI can be tokenistic, which may limit this potential. Furthermore, few studies report PPI processes and impact, particularly in doctoral research studies, which are seldom reported in peer‐reviewed papers. The aim of this paper was to explore the impact of PPI on two health‐related doctoral research studies and identify how PPI could be used meaningfully at this level.MethodThe PPI processes included (a) involvement of two ‘Research Buddies’ who informed the research design and ensured implementation of a booklet intervention was feasible for family carers, (b) data analysis workshops with ‘Research Buddies’ to identify emerging themes from practitioner interviews, (c) public and stakeholder involvement who informed data collection tool design, and the design of an intervention to help people with obesity who attend weight loss groups.FindingsThe application of PPI enhanced both doctoral studies by assisting data analysis; problem solving and improving recruitment rates; improving the usability and appeal of data collection tools and interventions; and developing implementation strategies. Patient and public involvement was considered a rewarding experience for both researchers and PPI contributors.ConclusionThis paper demonstrates the value of PPI in doctoral research in relation to its impact on research processes, researchers and contributors. We also present recommendations on how PPI could be incorporated into future doctoral research, including resources required, planning PPI processes and involving PPI contributors in all stages of research.
Multipotentiality of skin‐derived precursors: application to the regeneration of skin and other tissues
Authors: Bergeron L. , Busuttil V. , Botto J.‐M. 
Published: October 2019

AbstractSkin‐derived precursors (SKPs) have been described as multipotent dermal precursors. Here, we provide a review of the breadth and depth of scientific literature and studies regarding SKPs, accounting for a large number of scientific publications. Interestingly, these progenitors can be isolated from embryonic and adult skin, as well as from a population of dermal cells cultured in vitro in monolayer. Gathering information from different authors, this review explores different aspects of the SKP theme, such as the potential distinct origins of SKPs in rodents and in humans, and also their ability to differentiate in vitro and in vivo into multiple lineages of different progeny. This remarkable capacity makes SKPs an interesting endogenous source of precursors to explore in the framework of experimental and therapeutic applications in different domains. SKPs are not only involved in the skin’s dermal maintenance and support as well as wound healing, but also in hair follicle morphogenesis. This review points out the interests of future researches on SKPs for innovative perspectives that may be helpful in many different types of scientific and medical domains.
Investigating consumers’ green values and food‐related behaviours in Turkey
Authors: Gunden Cihat , Atis Ela , Salali H. Ece 
Published: October 2019

AbstractThis study sets out to examine the influence of consumers’ green values on food‐related behaviours. Data were collected from a random sample of 385 consumers in Izmir, Turkey via face‐to‐face interviews. Factor analysis was conducted to identify the underlying dimensions that capture the meaning of green values, which affect shopping, cooking and eating behaviours of consumers. A composite variable that represents consumers’ perception of green values was created to classify consumers into two segments labelled: Negative perceivers (37.7%) and positive perceivers (62.3%). The results indicated that the positive perceivers tended to have healthier and environmentally friendly food consumption behaviours than the negative perceivers. Gender, age, education, marital status, body mass index, regular exercise and smoking were significant for differentiating between the segments. We intend to construct value‐based intervention programmes that are easy to implement, non‐mandatory and cost‐effective for the negative perceivers.
The immunoglobulin γ marker 17 allotype and KIR/HLA genes prevent the development of chronic hepatitis B in humans
Authors: Di Bona Danilo , Pandey Janardan P. , Aiello Anna , Bilancia Massimo , Candore Giuseppina , Caruso Calogero , Colomba Claudia , Duro Giovanni , Ligotti Mattia Emanuela , Macchia Luigi , Rizzo Sergio , Accardi Giulia 
Published: October 2019

SummaryHepatitis B virus (HBV) infection causes a self‐limiting disease in most individuals. However, < 10% of infected subjects develop a chronic disease. Genetic host variability of polymorphic genes at the interface of innate and acquired immunity, such as killer immunoglobulin‐like receptors (KIR), their human leucocyte antigen (HLA) and IgG allotypes (GM), could explain this different clinical picture. We previously showed a protective role of the KIR2DL3 gene for the development of chronic hepatitis B (CHB), and a detrimental role of the KIR ligand groups, HLA‐A‐Bw4 and HLA‐C2. We have expanded the previous analysis genotyping patients for GM23 and GM3/17 allotypes. The comparison of the patients with CHB with those who resolved HBV infection showed that the presence of GM17 allele virtually eliminated the risk of developing CHB (OR, 0·03; 95% CI, 0·004–0·16; P < 0·0001). In addition, the combination of GM17, KIR2DL3, HLA‐A‐Bw4 and HLA‐C2 was highly sensitive to predict the outcome of HBV infection.
Implications of the movement behaviour of African tigerfishHydrocynus vittatusfor the design of freshwater protected areas
Authors: Jacobs Francois J. , Næsje Tor F. , Ulvan Eva M. , Weyl Olaf L. F. , Tiyeho Deon , Hay Clinton J. , O'Brien Gordon C. , Downs Colleen T. 
Published: October 2019

AbstractAfrican tigerfishHydrocynus vittatus(n =35) were tagged with external radio‐transmitters in the Kavango River, Namibia, to determine whether freshwater protected areas could be an effective tool for the management and conservation of this species. They were manually tracked in the core study area of 33 km everyc. 12 days from July–October 2016 to May 2017 for between 123 to 246 days. In addition, 14 extended surveys were carried out for up to 680 km to determine the total area use of the tagged individuals. Tigerfish displayed at least two behavioural patterns either having high site fidelity with shorter movements or using larger areas with longer movements. Twenty‐three (66%) of the tigerfish had high site fidelity using an area of less than 33 km of river, whereas 12 tigerfish (34%) undertook long distance movements of up to 397 km upstream and 116 km downstream from their tagging locations. During the long‐distance movements tigerfish crossed the territorial boundaries of Angola, Namibia and Botswana. Of the 35 fish that were monitored, 14 (40%) spent more than 80% of the monitored time in the 33 km study area and 18 (51%) stayed within the study area for at least 50% of the monitored time. These findings suggest that freshwater protected areas may be a useful management tool and we predict that a protected river area of 2–5 km river length could protect 25.9–34.6% of the population for at least 75% of the time whereas protection of 10 km river length could protect at least 50% of tigerfish for at least 75% of the time.
A pilot study of the performance of captive‐reared delta smelt Hypomesus transpacificus in a semi‐natural environment
Authors: Hung Tien‐Chieh , Rosales Marlin , Kurobe Tomofumi , Stevenson Troy , Ellison Luke , Tigan Galen , Sandford Marade , Lam Chelsea , Schultz Andrew , Teh Swee 
Published: October 2019

AbstractA captive breeding programme was developed in 2008 for delta smelt Hypomesus transpacificus in reaction to dramatic population decline over several decades. We took 526 sub‐adult captive‐reared delta smelt and cultured them for 200 days without providing artificial food or water quality management to assess their performance once released in the wild. The results indicated captive‐reared sub‐adult delta smelt could survive in a semi‐natural environment with uncontrolled water quality and naturally produced wild prey through spawning and into their post spawning phase.