bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pre-post, mixed-methods feasibility study of the WorkingWell mobile support tool for individuals with serious mental illness in the USA: a pilot study protocol
Authors: Nicholson Joanne , Wright Spenser M , Carlisle Alyssa M 
Published: February 2018

IntroductionSuccessful competitive employment has been found to be related to enhanced self-esteem, higher quality of life and reduced mental health service use for individuals living with serious mental illnesses (SMIs) including schizophrenia, bipolar disorder and major depression. The effectiveness of the individual placement and support model has been demonstrated in multiple randomised controlled trials in many countries. The management of stress, depression and anxiety in the workplace may be effectively enhanced through digital mental health interventions. The WorkingWell mobile support tool (‘app’) is specifically designed to meet the need for illness management support for individuals with SMI in the workplace, as an adjunct to professional treatment.Methods and analysisThe WorkingWell app, grounded in evidence-based supported employment, is informed by user experience design. It will be tested in a pre-post design, mixed-methods pilot study to explore issues of feasibility, acceptability and usefulness, and to provide preliminary data on the impact of use. Putative mediators of improved job tenure and psychological well-being, including postintervention changes in social support, self-efficacy and work-related motivation, will be investigated. Forty individuals at least 18 years of age, meeting the eligibility requirements for supported employment services (ie, diagnosed with a mental illness meeting the criteria for severity, duration and treatment), working a minimum of 10 hours per week at study enrolment, and speaking, reading and writing in English will be recruited for the pilot study. Research staff will recruit individuals at community-based mental health agencies; provide orientation to the study, the study smartphones and the WorkingWell app; conduct research interviews including standardised measures as well as semistructured items; and provide technical assistance in telephone calls and inperson meetings. A sample of 10 agency staff will be recruited to obtain further information on the feasibility, acceptability and usefulness of WorkingWell.Ethics and disseminationThe study design and procedures are approved by the Dartmouth-Hitchcock Medical Center Committee for the Protection of Human Subjects, the Massachusetts Department of Mental Health Central Office Research Review Committee and the Vermont Agency of Human Services Institutional Review Board. Study findings will be disseminated to agency partners, state agencies and funders, and to the research and technology development communities. Findings from the study will inform the design, data collection procedures and protocol for future full-scale randomised controlled trial testing of the effectiveness of the WorkingWell app, as well as investigations of work-related variables as mediators of psychological well-being and quality of life for individuals with SMI.
Breast carcinoma in sclerosing adenosis: a clinicopathological and immunophenotypical analysis on 206 lesions
Authors: Yu Bao-Hua , Tang Shao-Xian , Xu Xiao-Li , Cheng Yu-Fan , Bi Rui , Shui Ruo-Hong , Tu Xiao-Yu , Lu Hong-Fen , Zhou Xiao-Yan , Yang Wen-Tao 
Published: February 2018

AimsTo fully elucidate the clinicopathological features of breast carcinoma in sclerosing adenosis (SA-BC).MethodsClinical and histological characteristics of 206 SA-BCs from 180 patients were retrospectively evaluated. Immunohistochemical phenotype was examined. The clinicopathological relevance of the topographical pattern of SA-BCs was analysed.ResultsOverall, up to 46 patients (25.6%) had contralateral cancer, either SA associated or not. Of 99 cases who underwent core needle biopsy (CNB), 36 were underestimated as adenosis or atypical ductal hyperplasia at CNB, 5 invasive cases were misinterpreted as in situ carcinomas, whereas 4 ductal carcinoma in situ (DCIS) cases were overdiagnosed as invasive carcinoma. Microscopically, 163 tumours were in situ, including 136 DCIS, 19 lobular carcinomas in situ (LCIS) and 8 mixed DCIS/LCIS; of these carcinomas in situ (CIS), 37 had microinvasion. The DCIS group exhibited low, intermediate and high grades in 53.7%, 34.6% and 11.8% of cases, respectively, mostly with solid (43.4%) or cribriform (41.9%) pattern. Forty out of 43 invasive cases were invasive ductal carcinoma (IDC), mostly DCIS predominant. Immunophenotypically, luminal A phenotype was identified in 55.1%, 63.2% and 45.0% of DCIS, LCIS and IDC cases, respectively. Topographical type A group (carcinoma being entirely confined to SA, n=176) was characterised by smaller size, less invasiveness, lower grade and more frequency of luminal A immunophenotype compared with type B group (≥ 50% but not all of the carcinomatous lesion being located in SA, n=30) (all P<0.05).ConclusionsCIS, especially non-high-grade DCIS, represents the most common variant of SA-BC, and luminal A is the most predominant immunophenotype. CNB assessment might be challenging in some SA-BCs. The topographical pattern has great clinicopathological relevance. Careful evaluation of the contralateral breast and long-term follow-up for patients with SA-BC is necessary given its high prevalence of bilaterality.
Comparing the characteristics of users of an online service for STI self-sampling with clinic service users: a cross-sectional analysis
Authors: Barnard Sharmani , Free Caroline , Bakolis Ioannis , Turner Katy M E , Looker Katharine J , Baraitser Paula 
Published: February 2018

ObjectivesOnline services for self-sampling at home could improve access to STI testing; however, little is known about those using this new modality of care. This study describes the characteristics of users of online services and compares them with users of clinic services.MethodsWe conducted a cross-sectional analysis of routinely collected data on STI testing activity from online and clinic sexual health services in Lambeth and Southwark between 1January 2016 and 31March 2016. Activity was included for chlamydia, gonorrhoea, HIV and syphilis testing for residents of the boroughs aged 16 years and older. Logistic regression models were used to explore potential associations between type of service use with age group, gender, ethnic group, sexual orientation, positivity and Index of Multiple Deprivation (IMD) quintiles. We used the same methods to explore potential associations between return of complete samples for testing with age group, gender, ethnic group, sexual orientation and IMD quintiles among online users.Results6456 STI tests were carried out by residents in the boroughs. Of these, 3582 (55.5%) were performed using clinic services and 2874 (44.5%) using the online service. In multivariate analysis, online users were more likely than clinic users to be aged between 20 and 30 years, female, white British, homosexual or bisexual, test negative for chlamydia or gonorrhoea and live in less deprived areas. Of the individuals that ordered a kit from the online service, 72.5% returned sufficient samples. In multivariate analysis, returners were more likely than non-returners to be aged >20 years and white British.ConclusionNearly half (44.5%) of all basic STI testing was done online, although the characteristics of users of clinic and online services differed and positivity rates for those using the online service for testing were lower. Clinics remain an important point of access for some groups.
Counting crocodiles from the sky: monitoring the critically endangered gharial (Gavialis gangeticus) population with an unmanned aerial vehicle (UAV)
Authors: Thapa Gokarna Jung , Thapa Kanchan , Thapa Ramesh , Jnawali Shant Raj , Wich Serge A. , Poudyal Laxman Prasad , Karki Suraj 
Published: February 2018

Technology is rapidly changing the methods used in the field of wildlife monitoring. Unmanned aerial vehicles (UAV) are an example of a new technology that allows biologists to take to the air to monitor wildlife. A fixed-wing UAV was used to monitor the critically endangered gharial population along 46 km of the Babai River in Bardia National Park, Nepal. The UAV was flown at an altitude of 80 m along 12 pre-designed missions and, with a search effort of 2.72 h of flight time, acquired a total of 11 799 images covering an effective surface area of 8.2 km2 of riverbank habitat. The images taken from the UAV could differentiate between gharial and muggers. A total count of 33 gharials and 31 muggers with observed density (per square kilometre) of 4.64 and 4.0 for gharial and mugger, respectively. Comparison of count data between one-time UAV and multiple conventional visual encounter rate surveys’ data showed no significant difference in the mean. Basking season and turbidity were important factors for monitoring crocodiles along the riverbank habitat. Efficacy of monitoring crocodiles by UAV at the given altitude can be replicated in high-priority areas with lower operating cost and acquisition of high-resolution data.
Exact determination of asymptotic CMB temperature-redshift relation
Authors: Hahn Steffen , Hofmann Ralf 
Published: February 2018

Based on energy conservation in a Friedmann–Lemaître–Robertson–Walker (FLRW) Universe, on the Legendre transformation between energy density and pressure, and on nonperturbative asymptotic freedom at high temperatures, we derive the coefficient [Formula: see text] in the high-temperature [Formula: see text] — redshift [Formula: see text] relation, [Formula: see text], of the Cosmic Microwave Background (CMB). Theoretically, our calculation relies on a deconfining SU(2) rather than a U(1) photon gas. We prove that [Formula: see text], representing a topological invariant. Interestingly, the relative deviation of [Formula: see text] from the critical exponent associated with the correlation length [Formula: see text] of the 3D Ising model, [Formula: see text], is less than [Formula: see text]. We are not in a position to establish a direct theoretical link between [Formula: see text] and [Formula: see text] as suggested by the topological nature of [Formula: see text] and the fact that both theories are members of the same universality class. We do, however, spell out a somewhat speculative, strictly monotonic map from the physical Ising temperature [Formula: see text] to a fictitious SU(2) Yang–Mills temperature [Formula: see text], the latter continuing the asymptotic dependence of the scale factor [Formula: see text] on [Formula: see text] for [Formula: see text] down to [Formula: see text], and we identify an exponential map from [Formula: see text] to [Formula: see text] to reproduce critical Ising behavior.
Results of the Volar Approach in Proximal Interphalangeal Joint Arthroplasty
Authors: Duncan Scott F. M. , Smith Anthony A. , Renfree Kevin J. , Dunbar Ross M. , Merritt Marianne V. 
Published: February 2018

Background: Most hand surgeons use a dorsal approach for proximal interphalangeal (PIP) joint implant arthroplasty. However, a volar approach offers the advantage of no disturbance to the extensor mechanism, thus allowing early initiation of active range of motion. We examined our results in patients who underwent PIP joint arthroplasty via a volar approach.Methods: Using a retrospective chart review, we evaluated the outcomes of patients undergoing PIP joint arthroplasty through a volar approach between 2001 and 2005 by 3 fellowship-trained hand surgeons at our institution. The indication for surgery was PIP joint pain with radiographic evidence of joint destruction. Variables included implant type, diagnosis, affected digit(s), preoperative and postoperative range of motion, and complications. Hand therapy was initiated on postoperative day 3 or 4.Results: Over the 5 years, 25 PIP joints were replaced in 18 women and 2 men with the volar approach. Replacements consisted of 14 surface replacement prostheses, 9 pyrocarbon prostheses, and 2 silicone prostheses. The average age of patients at prosthesis implantation was 64 years (range, 39–75 years). Prostheses were placed in 1 index, 12 long, 7 ring, and 5 small digits. Average follow-up period was 33 months (range, 24–69 months). Preoperative diagnoses were osteoarthritis (14), rheumatoid arthritis (4), and posttraumatic arthritis (2). Preoperative total arc of motion averaged 42° (range, 0° extension to 80° flexion); postoperative total arc of motion averaged 56° (range, –10° extension to 90° flexion). Complications comprised 1 swan neck deformity, 1 deep infection, 1 dislocation (early), and 2 loose implants with flexion contractures. Seventeen patients had minimal or no pain at their last follow-up visit.Conclusions: PIP joint arthroplasty can be successfully implemented through a volar approach with various implant types and has outcomes similiar to the published results of the dorsal approach.
Ex-vivo Tendon Repair Augmented with Bone Marrow Derived Mesenchymal Stem Cells Stimulated with Myostatin for Tenogenesis
Authors: Le Wei , Cheah Andre Eu-Jin , Yao Jeffrey 
Published: February 2018

Background: To investigate the effect of myostatin (GDF-8) stimulation of bone marrow derived mesenchymal stem cells (BMSCs) on tenogenesis in the setting of tendon repair. GDF-8 has demonstrated the ability to augment tenogenesis and we sought to identify if this effect could lead to the focused differentiation of pluripotential stem cells down a tenocyte lineage ex vivo.Methods: Cadaveric upper limb flexor tendons were harvested, decellularized and divided into 1 cm segments. Sutures seeded with stem cells were passed through tendon segments to simulate repair. The repaired tendons were then cultured either with or without myostatin for 3, 5, and 7 days. The experiment was also repeated with non-decellularized tendons for a total of 4 groups. The tendons were then evaluated for the expression of scleraxis and tenomodulin, two biomarkers for tendon.Results: Myostatin stimulation led to an increase in expression of tenomodulin and scleraxis at 5 and 7 days in both the decellularized and non-decellularized tendons. Myostatin increased the differentiation of BMSCs into tenocytes and/or led to the upregulation of tenomodulin and scleraxis production by the native tenocytes present within the non-decellularized tendons.Conclusions: The addition of myostatin to BMSCs leads to tenocyte differentiation as evidenced by the expression of tenocyte biomarkers, scleraxis and tenomodulin. This effect is maintained in an ex vivo tendon repair model suggestive that these cells survive the passage through tendon tissue and remain metabolically active.
Complications of Intramedullary Fixation for Distal Radius Fractures in Elderly Patients: A Retrospective Analysis Using McKay’s Complication Checklist
Authors: Wakasugi Takuma , Shirasaka Ritsuro , Kawauchi Toshiyuki , Fujita Koji , Okawa Atsushi 
Published: February 2018

Background: Intramedullary fixation for distal radius fractures is reported to be free of hardware irritation and less invasive than other fixation methods. Some specific complications associated with intramedullary fixation, such as radial nerve sensory neuritis, have been reported, but no study has focused on the complication rates of intramedullary fixation for distal radius fractures in the elderly population. Furthermore, no studies have analyzed common complications, such as carpal tunnel syndrome and flexor tenosynovitis including trigger finger, among patients with distal radius fractures treated by intramedullary fixation based on a comprehensive complication checklist. Methods: We reviewed the medical records of 52 elderly patients with distal radius fractures treated with intramedullary nail fixation. We investigated the postoperative complications in these patients using McKay’s complication checklist. Results: 5 patients experienced radial nerve sensory disorder, and one patients developed carpal tunnel syndrome. All neurological symptoms resolved spontaneously, and these neurological complications were categorized as mild. Further, 3 patients developed trigger finger at the A1 pulley and needed triamcinolone injections for symptomatic relief. There were no tendinous complications around the implanted hardware. All tendinous complications were categorized as moderate complications and resolved with steroid injection therapy. Among skeletal complications, 1 case of postoperative volar displacement resolved with good functional outcome without the need for corrective osteotomy. This was considered a mild complication. The total complication rate was 19.2%. All complications were categorized as mild or moderate, and no patients experienced severe complications that needed further surgery such as hardware removal. Conclusions: Intramedullary fixation for distal radius fractures was free from tendinous complications such as tenosynovitis and tendon ruptures around the implant, which are frequently caused by volar locking plate fixation. However, this less invasive technique could not avoid common complications such as trigger finger and carpal tunnel syndrome associated with distal radius fractures.
Religious Minorities and Freedom of Religion or Belief in the uk
Authors: Weller Paul 
Published: February 2018

Abstract
By particular reference to the polity of the uk, this article discusses issues and options for groups identified as “religious minorities” in relation to issues of “religious freedom”. It does so by seeking to ensure that such contemporary socio-legal discussions are rooted empirically in the full diversity of the uk’s contemporary religious landscape, while taking account of (especially) 19th century (mainly Christian) historical antecedents. It argues that properly to understand the expansion in scope and substance of religious freedom achieved in the 19th century that account needs to be taken of the agency of the groups that benefited from this. Finally, it argues this history can be seen as a “preconfiguration” of the way in which religious minorities have themselves acted as key drivers for change in relevant 20th and 21st century uk law and social policy and could continue to do so in possible futures post-Brexit Referendum.
Atmospheric Dynamics Feedback: Concept, Simulations, and Climate Implications
Authors: Byrne Michael P. , Schneider Tapio 
Published: February 2018

AbstractThe regional climate response to radiative forcing is largely controlled by changes in the atmospheric circulation. It has been suggested that global climate sensitivity also depends on the circulation response, an effect called the “atmospheric dynamics feedback.” Using a technique to isolate the influence of changes in atmospheric circulation on top-of-the-atmosphere radiation, the authors calculate the atmospheric dynamics feedback in coupled climate models. Large-scale circulation changes contribute substantially to all-sky and cloud feedbacks in the tropics but are relatively less important at higher latitudes. Globally averaged, the atmospheric dynamics feedback is positive and amplifies the near-surface temperature response to climate change by an average of 8% in simulations with coupled models. A constraint related to the atmospheric mass budget results in the dynamics feedback being small on large scales relative to feedbacks associated with thermodynamic processes. Idealized-forcing simulations suggest that circulation changes at high latitudes are potentially more effective at influencing global temperature than circulation changes at low latitudes, and the implications for past and future climate change are discussed.
Phase II, Open-Label, Randomized, Multicenter Trial (HERBY) of Bevacizumab in Pediatric Patients With Newly Diagnosed High-Grade Glioma
Authors: Grill Jacques , Massimino Maura , Bouffet Eric , Azizi Amedeo A. , McCowage Geoffrey , Cañete Adela , Saran Frank , Le Deley Marie-Cécile , Varlet Pascale , Morgan Paul S. , Jaspan Tim , Jones Chris , Giangaspero Felice , Smith Helen , Garcia Josep , Elze Markus C. , Rousseau Raphaël F. , Abrey Lauren , Hargrave Darren , Vassal Gilles 
Published: February 2018

PurposeBevacizumab (BEV) is approved in more than 60 countries for use in adults with recurrent glioblastoma. We evaluated the addition of BEV to radiotherapy plus temozolomide (RT+TMZ) in pediatric patients with newly diagnosed high-grade glioma (HGG).MethodsThe randomized, parallel group, multicenter, open-label HERBY trial ( ClinicalTrials.gov identifier: NCT01390948) enrolled patients age ≥ 3 years to ≤ 18 years with localized, centrally neuropathology-confirmed, nonbrainstem HGG. Eligible patients were randomly assigned to receive RT + TMZ (RT: 1.8 Gy, 5 days per week, and TMZ: 75 mg/m2per day for 6 weeks; 4-week treatment break; then up to 12 × 28-day cycles of TMZ [cycle 1: 150 mg/m2per day, days 1 to 5; cycles 2 to 12: 200 mg/m2per day, days 1 to 5]) with or without BEV (10 mg/kg every 2 weeks). The primary end point was event-free survival (EFS) as assessed by a central radiology review committee that was blinded to treatment. We report findings of EFS at 12 months after the enrollment of the last patient.ResultsOne hundred twenty-one patients were enrolled (RT+TMZ [n = 59]; BEV plus RT+TMZ [n = 62]). Central radiology review committee–assessed median EFS did not differ significantly between treatment groups (RT+TMZ, 11.8 months; 95% CI, 7.9 to 16.4 months; BEV plus RT+TMZ, 8.2 months; 95% CI, 7.8 to 12.7 months; hazard ratio, 1.44; P = .13 [stratified log-rank test]). In the overall survival analysis, the addition of BEV did not reduce the risk of death (hazard ratio, 1.23; 95% CI, 0.72 to 2.09). More patients in the BEV plus RT+TMZ group versus the RT+TMZ group experienced one or more serious adverse events (n = 35 [58%] v n = 27 [48%]), and more patients who received BEV discontinued study treatment as a result of adverse events (n = 13 [22%] v n = 3 [5%]).ConclusionAdding BEV to RT+TMZ did not improve EFS in pediatric patients with newly diagnosed HGG. Our findings were not comparable to those of previous adult trials, which highlights the importance of performing pediatric-specific studies.
Inhibiting Cellular Senescence: A New Therapeutic Paradigm for Age-Related Osteoporosis
Authors: Khosla Sundeep , Farr Joshua N , Kirkland James L 
Published: February 2018

Abstract

Context
With the aging of the population and projected increase in osteoporotic fractures coupled with the declining use of osteoporosis medications, there is a compelling need for new approaches to treat osteoporosis. Given that age-related osteoporosis generally coexists with multiple other comorbidities (e.g., atherosclerosis, diabetes, frailty) that share aging as the leading risk factor, there is growing interest in the “Geroscience Hypothesis,” which posits that manipulation of fundamental aging mechanisms will delay the appearance or severity of multiple chronic diseases because these diseases share aging as the underlying risk factor. In this context, one fundamental aging mechanism that has received considerable attention recently as contributing to multiple age-related morbidities is cellular senescence. This mini-review provides an overview on cellular senescence with a focus on its role in mediating age-related bone loss.

Methods
This summary is based on the authors’ knowledge of the field supplemented by a PubMed search using the terms “senescence,” “aging,” and “bone.”

Results
There is compelling evidence from preclinical models and supportive human data demonstrating an increase in senescent cells in the bone microenvironment with aging. These cells produce a proinflammatory secretome that leads to increased bone resorption and decreased bone formation, and approaches that either eliminate senescent cells or impair the production of their proinflammatory secretome have been shown to prevent age-related bone loss in mice.

Conclusions
Targeting cellular senescence represents a novel therapeutic strategy to prevent not only bone loss but potentially multiple age-related diseases simultaneously.