bluuebunny/crossref_metadata_2025_split huggingface dataset:
SIRveNIB: Selective Internal Radiation Therapy Versus Sorafenib in Asia-Pacific Patients With Hepatocellular Carcinoma
Authors: Chow Pierce K.H. , Gandhi Mihir , Tan Say-Beng , Khin Maung Win , Khasbazar Ariunaa , Ong Janus , Choo Su Pin , Cheow Peng Chung , Chotipanich Chanisa , Lim Kieron , Lesmana Laurentius A. , Manuaba Tjakra W. , Yoong Boon Koon , Raj Aloysius , Law Chiong Soon , Cua Ian H.Y. , Lobo Rolley R. , Teh Catherine S.C. , Kim Yun Hwan , Jong Yun Won , Han Ho-Seong , Bae Si-Hyun , Yoon Hyun-Ki , Lee Rheun-Chuan , Hung Chien-Fu , Peng Cheng-Yuan , Liang Po-Chin , Bartlett Adam , Kok Kenneth Y.Y. , Thng Choon-Hua , Low Albert Su-Chong , Goh Anthony S.W. , Tay Kiang Hiong , Lo Richard H.G. , Goh Brian K.P. , Ng David C.E. , Lekurwale Ganesh , Liew Wei Ming , Gebski Val , Mak Kenneth S.W. , Soo Khee Chee ,   on behalf of Asia-Pacific Hepatocellular Carcinoma Trials Group
Published: March 2018

Purpose Selective internal radiation therapy or radioembolization (RE) shows efficacy in unresectable hepatocellular carcinoma (HCC) limited to the liver. This study compared the safety and efficacy of RE and sorafenib in patients with locally advanced HCC. Patients and Methods SIRveNIB (selective internal radiation therapy v sorafenib), an open-label, investigator-initiated, phase III trial, compared yttrium-90 (90Y) resin microspheres RE with sorafenib 800 mg/d in patients with locally advanced HCC in a two-tailed study designed for superiority/detriment. Patients were randomly assigned 1:1 and stratified by center and presence of portal vein thrombosis. Primary end point was overall survival (OS). Efficacy analyses were performed in the intention-to-treat population and safety analyses in the treated population. Results A total of 360 patients were randomly assigned (RE, 182; sorafenib, 178) from 11 countries in the Asia-Pacific region. In the RE and sorafenib groups, 28.6% and 9.0%, respectively, failed to receive assigned therapy without significant cross-over to either group. Median OS was 8.8 and 10.0 months with RE and sorafenib, respectively (hazard ratio, 1.1; 95% CI, 0.9 to 1.4; P = .36). A total of 1,468 treatment-emergent adverse events (AEs) were reported (RE, 437; sorafenib, 1,031). Significantly fewer patients in the RE than sorafenib group had grade ≥ 3 AEs (36 of 130 [27.7%]) v 82 of 162 [50.6%]; P < .001). The most common grade ≥ 3 AEs were ascites (five of 130 [3.8%] v four of 162 [2.5%] patients), abdominal pain (three [2.3%] v two [1.2%] patients), anemia (zero v four [2.5%] patients), and radiation hepatitis (two [1.5%] v zero [0%] patients). Fewer patients in the RE group (27 of 130 [20.8%]) than in the sorafenib group (57 of 162 [35.2%]) had serious AEs. Conclusion In patients with locally advanced HCC, OS did not differ significantly between RE and sorafenib. The improved toxicity profile of RE may inform treatment choice in selected patients.
EGFR Genotyping of Matched Urine, Plasma, and Tumor Tissue in Patients With Non–Small-Cell Lung Cancer Treated With Rociletinib, an EGFR Tyrosine Kinase Inhibitor
Authors: Goldman Jonathan W. , Karlovich Chris , Sequist Lecia V. , Melnikova Vlada , Franovic Aleksandra , Gadgeel Shirish M. , Reckamp Karen L. , Camidge D. Ross , Pérol Maurice , Ou Sai-Hong Ignatius , Liu Stephen V. , Yu Helena A. , Soria Jean-Charles , Socinski Mark A. , Mekhail Tarek M. , Solomon Benjamin J. , Natale Ronald B. , Otterson Gregory A. , Papadimitrakopoulou Vassiliki , Langer Corey J. , Neal Joel W. , Despain Darrin , Yurasov Sergey , Litten Jason B. , Erlander Mark , Raponi Mitch , Wakelee Heather A. 
Published: March 2018

Purpose Liquid biopsies represent an attractive alternative to tissue biopsies, particularly rebiopsies, in determining patient eligibility for targeted therapies. Clinical utility of urine genotyping, however, has not been explored extensively. We evaluated epidermal growth factor receptor ( EGFR) T790M detection in matched urine, plasma, and tissue and the clinical outcomes of patients with advanced non–small-cell lung cancer treated with rociletinib. Methods Tissue (n = 540), plasma (n = 482), and urine (n = 213) were collected from evaluable patients enrolled in TIGER-X, a phase I/II study. Genotyping was performed by therascreen EGFR testing in tissue, BEAMing in plasma, and a quantitative short footprint assay (Trovera) in urine, which was used to further examine discordant samples. Results Positive percent agreement with tissue T790M results was similar for urine (82%; 142 of 173) and plasma (81%; 313 of 387) genotyping. Urine and plasma together identified more patients who were T790M positive (92%) than tissue alone (83%) among matched samples (n = 177). The ability to identify mutations in plasma was strongly associated with M stage ( P < .001); rate of T790M detection for patients with M1a/M0 disease increased from 54% for plasma alone to 85% when urine and plasma were both examined. Objective response rates of patients who were T790M positive were comparable between tumor (34%), plasma (32%), and urine (37%). Conclusion Clinical response to rociletinib was comparable irrespective of whether T790M status was identified by liquid or tissue biopsy. Combined, urine and plasma identified a higher percentage of patients who were T790M positive than tumor genotyping alone and improved detection of T790M, particularly in the absence of distant metastases. These findings support the noninvasive analysis of urine and plasma before tumor rebiopsy when assessing T790M status.
Immunosensors Made with Layer-by-Layer Films on Chitosan/Gold Nanoparticle Matrices to Detect D-Dimer as Biomarker for Venous Thromboembolism
Authors: Rodrigues Valquiria C , Moraes Marli L , Soares Juliana C , Soares Andrey C , Sanfelice Rafaela , Deffune Elenice , Oliveira Osvaldo N 
Published: March 2018

Abstract
We report on immunosensors to detect D-dimer, a biomarker of venous thromboembolism, which are made with layer-by-layer (LbL) films containing immobilized anti-D-dimer monoclonal antibody alternated with a layer of chitosan/gold nanoparticles (AuNpChi). Detection was due to irreversible adsorption of the antigen D-dimer on its corresponding antibody according to a Langmuir-Freundlich model, thus giving rise to ellipsoidal structures in scanning electron microscopy images whose size and number increased with D-dimer concentration. The chemical groups involved in the adsorption process were inferred from polarization-modulated infrared reflection absorption (PM-IRRAS) through changes in the amide and carbonyl bands. Detection of D-dimer was made with electrical impedance spectroscopy, electrochemical impedance spectroscopy and cyclic voltammetry. The latter was the most sensitive with a detection limit of 9 × 10−4 µg/mL, sensitivity of 0.27 × 10−6 A/µgmL−1 with linear increase from 0 to 1 µg/mL. The selectivity of the immunosensor made with AuNpChi/anti-D-dimer film was verified by noting negligible changes in the cyclic voltammograms when exposed to typical interferents in biological fluids.
Ethanol production using vegetable peels medium and the effective role of cellulolytic bacterial (Bacillus subtilis) pre-treatment
Authors: Promon Salman Khan , Kamal Wasif , Rahman Shafkat Shamim , Hossain M. Mahboob , Choudhury Naiyyum 
Published: March 2018

Background: The requirement of an alternative clean energy source is increasing with the elevating energy demand of modern age. Bioethanol is considered as an excellent candidate to satiate this demand.Methods:Yeast isolates were used for the production of bioethanol using cellulosic vegetable wastes as substrate. Efficient bioconversion of lignocellulosic biomass into ethanol was achieved by the action of cellulolytic bacteria (Bacillus subtilis). After proper isolation, identification and characterization of stress tolerances (thermo-, ethanol-, pH-, osmo- & sugar tolerance), optimization of physiochemical parameters for ethanol production by the yeast isolates was assessed. Very inexpensive and easily available raw materials (vegetable peels) were used as fermentation media. Fermentation was optimized with respect to temperature, reducing sugar concentration and pH.Results:It was observed that temperatures of 30°C and pH 6.0 were optimum for fermentation with a maximum yield of ethanol. The results indicated an overall increase in yields upon the pretreatment ofBacillus subtilis; maximum ethanol percentages for isolate SC1 obtained after 48-hour incubation under pretreated substrate was 14.17% in contrast to untreated media which yielded 6.21% after the same period. Isolate with the highest ethanol production capability was identified as members of the ethanol-producingSaccharomycesspecies after stress tolerance studies and biochemical characterization using Analytical Profile Index (API) ® 20C AUX and nitrate broth test. Introduction ofBacillus subtilisincreased the alcohol production rate from the fermentation of cellulosic materials.Conclusions:The study suggested that the kitchen waste can serve as an excellent raw material in ethanol fermentation.
Taxa: An R package implementing data standards and methods for taxonomic data
Authors: Foster Zachary S.L. , Chamberlain Scott , Grünwald Niklaus J. 
Published: March 2018

The taxa R package provides a set of tools for defining and manipulating taxonomic data. The recent and widespread application of DNA sequencing to community composition studies is making large data sets with taxonomic information commonplace. However, compared to typical tabular data, this information is encoded in many different ways and the hierarchical nature of taxonomic classifications makes it difficult to work with. There are many R packages that use taxonomic data to varying degrees but there is currently no cross-package standard for how this information is encoded and manipulated. We developed the R package taxa to provide a robust and flexible solution to storing and manipulating taxonomic data in R and any application-specific information associated with it. Taxa provides parsers that can read common sources of taxonomic information (taxon IDs, sequence IDs, taxon names, and classifications) from nearly any format while preserving associated data. Once parsed, the taxonomic data and any associated data can be manipulated using a cohesive set of functions modeled after the popular R package dplyr. These functions take into account the hierarchical nature of taxa and can modify the taxonomy or associated data in such a way that both are kept in sync. Taxa is currently being used by the metacoder and taxize packages, which provide broadly useful functionality that we hope will speed adoption by users and developers.
The effectiveness of exercise-based vestibular rehabilitation in adult patients with chronic dizziness: A systematic review
Authors: Kundakci Burak , Sultana Anjum , Taylor Alan J , Alshehri Mansour Abdullah 
Published: March 2018

Background:Dizziness is a non-specific term used by patients to describe several symptoms ranging from true vertigo, light headedness, disorientation or sense of imbalance. Vestibular rehabilitation (VR) is a specific form of exercise-based therapy programme aimed at alleviating the primary and secondary problems of a vestibular pathology. The aim of this study was to investigate the effectiveness of exercise-based vestibular rehabilitation in adult patients with chronic dizziness.Methods:The following five databases were searched: the Cochrane Central Register of Controlled Trials (CENTRAL, the Cochrane Library), MEDLINE, PubMed, the Physiotherapy Evidence Database (PEDro) and Scopus (Elsevier). Two investigators independently reviewed all articles and a systematic review of literature was performed using the PRISMA guidelines (Preferred Reporting Items for Systematic Reviews and Meta-Analyses). The articles were included if they met the following inclusion criteria: (1) randomised controlled trial, (2) people with chronic dizziness, (3) adults aged 18 or over, (4) exercise-based VR, (5) VR exercises compared with sham or usual care, non-treatment or placebo and (6) only studies published full text in English.Results: The initial search identified 304 articles, four of which met the criteria for analysis. All studies involved some form of vestibular rehabilitation, including vestibular compensation, vestibular adaptation and substitution exercises. These exercises were compared with usual medical care (three studies) or placebo eye exercise (one study). The Vertigo Symptom Scale was the most commonly used outcome measure to assess subjective perception of symptoms of dizziness (three studies). According to the PEDro scale, three studies were considered to be of high quality, and one was rated as fair. Conclusions:This review suggests that exercise-based vestibular rehabilitation shows benefits for adult patients with chronic dizziness with regard to improvement in the vertigo symptom scale, fall risk, balance and emotional status.
A construção da narrativa em Primeiras Estórias
Authors: Veiga Benedito 
Published: March 2018

O trabalho examina as possibilidades de interpretação das Primeiras Estórias, propondo a ideia de que toda a ambiguidade da sequenciação das estórias, as “primeiras” e as “segundas”, é discutida em Pirlimpsiquice, em um jogo metafórico/simbólico.
An adverse events potential costs analysis based on Drug Programs in Poland. Dermatology focus
Authors: Szkultecka-Debek Monika , Drozd Mariola , Kiepurska Nina , Janowska Agnieszka , Paprzycki Piotr , Paluchowska Beata 
Published: March 2018

ABSTRACT
The aim of the project, carried out within the Polish Society for Pharmacoeconomics (PTFE), was to estimate the potential costs of treatment of the side effects which (theoretically) may occur as a result of treatments for the selected diseases. This paper deals solely with dermatology related events. Herein, several Drug Programs financed by the National Health Fund in Poland, in 2012, were analyzed. The adverse events were selected based on the Summary of Product Characteristics of the chosen products. We focused the project on those potential adverse events which were defined in SPC as frequent and very frequent. The results are presented according to their therapeutic areas, and in this paper, the focus is upon that which is related to dermatology. The events described as ‘very common’ had an incidence of ≥ 1/10, and that which is ‘common’ - ≥ 1/100, <1 /10. In order to identify the resources used, we, with the engagement of clinical experts, performed a survey. In our work, we employed only the total direct costs incurred by the public payer, based on valid individual cost data in February 2014. Moreover, we calculated the total spending from the public payer’s perspective, as well as the patient’s perspective, and the percentage of each component of the total cost in detail. The paper, thus, informs the reader of the estimated costs of treatment of side effects related to the dermatologic symptoms and reactions. Based on our work, we can state that the treatment of skin adverse drug reactions generates a significant cost - one incurred by both the public payer and the patient.
Kinetics of the decomposition and the estimation of the stability of 10% aqueous and non-aqueous hydrogen peroxide solutions
Authors: Zun Maria , Dwornicka Dorota , Wojciechowska Katarzyna , Swiader Katarzyna , Kasperek Regina , Rzadkowska Marzena , Poleszak Ewa 
Published: March 2018

Abstract
In this study, the stability of 10% hydrogen peroxide aqueous and non-aqueous solutions with the addition of 6% (w/w) of urea was evaluated. The solutions were stored at 20°C, 30°C and 40°C, and the decomposition of hydrogen peroxide proceeded according to first-order kinetics. With the addition of the urea in the solutions, the decomposition rate constant increased and the activation energy decreased. The temperature of storage also affected the decomposition of substance, however, 10% hydrogen peroxide solutions prepared in PEG-300, and stabilized with the addition of 6% (w/w) of urea had the best constancy.
A new diagnostic perspective – hyperglycemia in pregnancy – as of the year, 2014
Authors: Strawa-Zakoscielna Katarzyna , Lenart-Lipinska Monika , Szafraniec Aneta , Rudzki Grzegorz , Matyjaszek-Matuszek Beata 
Published: March 2018

Abstract
Gestational Diabetes Mellitus (GDM) is a growing epidemiological problem, and it is currently the most common metabolic disorder in pregnancy, as it affects approximately 2-6% of all pregnant women. In 2014, the Polish Diabetic Association introduced significant changes in the diagnosis of hyperglycemia as first diagnosed in pregnancy, based on the recommendations of the IADPSG of 2010 and WHO of 2013. There are now two categories: diabetes in pregnancy, and GDM. These involve different degrees of severity of metabolic complications for the mother and the growing fetus. Establishing a new diagnostic criterion is significant because of the negative impact of hyperglycemia on the fetus (especially in the first trimester), the increased prevalence of malformations or the possibility of spontaneous abortions in early pregnancy.
Is the vignette method used to assess quality of life in practice?
Authors: Szkultecka-Debek Monika , Drozd Mariola , Bem Marta , Kiepurska Nina , Mazur Joanna 
Published: March 2018

Abstract
Purpose. To define how extensive is the use of the vignettes method for quality of life assessment.
Methods. An internet search of different databases was performed to identify and enumerate the publications involving studies in which the vignettes method is employed in relation to quality of life assessment (QoL). PubMed-Medline and Cochrane were scrutinized for publications based on the same search criteria.
Results. Our search found that 6 Cochrane and 105 Medline publications, as well as 28 articles were published between 2011-2014. However, only 7 match the objective of the search.
Conclusion. The rating of vignettes is a promising additional technique to measure changes in QoL and utilities, however, it is not very often employed by the researchers. It can be considered for use as supplementary method to standard QoL measurement methods.
Anti-Helicobacter pylori activity in vitro of chamomile flowers, coneflower herbs, peppermint leaves and thyme herbs – a preliminary report
Authors: Malm Anna , Glowniak-Lipa Anna , Korona-Glowniak Izabela , Baj Tomasz 
Published: March 2018

Abstract
Recently, several studies have been undertaken so as to develop more effective therapeutic approaches towards eradicating Helicobacter pylori. Among these is phytotherapy. The aim of this study was to investigate the activity in vitro of the plant extracts obtained from common herbs cultivated in the Lubelszczyzna region against the reference strain H. pylori ATCC 43504. Among these are thyme herbs, chamomile flowers, peppermint leaves and coneflower herbs. Herein, it was found that the MIC values of the assayed extracts were as follows: the extracts from coneflower herbs showed anti-H. pylori activity with MIC = 31.3-125 μg/ml; the extracts from chamomile flowers demonstrated MIC = 31.3-62.5 μg/ ml; the extracts from peppermint leaves had MIC = 15.6-250 μg/ml; and the extracts from thyme herbs revealed MIC = 15.6-62.5 μg/ml, depending on the solvent used. The most active were the extracts obtained with ethyl acetate or ethanol alcohol absolute 99.8%. These showing MIC within the range of 15.6-62.5 μg/ml, while the lowest activity was observed in case of the extract obtained with 70% aqueous ethanol. This last showing MIC within the range of 62.5-250 μg/ml. The MIC values of essential oil components were 15.6 μg/ml for bisabolol and menthol or 31.3 μg/ml for thymol. The obtained data indicate that the assayed herbs possessed promising anti-H. pylori bioactivity.
The effect of a combined choline salicylate and cetalkonium chloride gel on particular strains of Pseudomonas aeruginosa, Staphylococcus spp. and Streptococcus spp.
Authors: Amangeldykyzy Saule , Nurlybek Aidana Nurlybekkyzy , Nurlan Aigerim Nurlybekkyzy , Juszkiewicz Konrad T. , Polski Andrzej , Seisembay Ulzhan Baurzhankyzy , Mukasheva Adiya Maksatovna , Umirzakovna Urumbaeva Kathira , Poleszak Ewa 
Published: March 2018

Abstract
The ongoing control of virulent bacteria strains is a challenge for today’s medicine. An example of this, is one widely used drug employed in treating less serious external oral and ocular bacterial infections. This is a gel containing both cetalkonium chloride and choline salicylate. However, whether in the era of expanding bacterial resistance this gel is still effective, is not clear. Hence, in our work, its antibacterial effect was studied against 13 strains of Pseudomonas aeruginosa, 6 strains of Staphylococcus spp. and 6 strains of Streptococcus spp. drawn from the collection of the Department of Microbiology, Virology and Immunology, Kazakh National Medical University, as well as against 30 strains of Staphylococcus spp. recently isolated from Kazakh medical students. This work demonstrated that Pseudomonas aeruginosa was insensitive to this preparation in all samples, while the sensitivity of Staphylococcus spp. and Streptococcus spp. was almost halved, compared to untreated samples. An interesting discovery was the greater resistance of strains obtained from student volunteers than from the collection. However, despite the evident resistance of some strains to the combined cetalkonium chloride and choline salicylate gel, we put forward that it can still be used in less serious external bacterial infections.
The knowledge of pregnant women regarding appropriate oral hygiene practices of young children – a questionnaire survey
Authors: Szalewska Magdalena , Boryczko Monika , Kapica Anna , Lemejda Justyna , Lukasik Marta , Pietryka-Michalowska Elzbieta , Szymanska Jolanta 
Published: March 2018

Abstract
Maintaining appropriate oral cavity hygiene in a young child is closely related to the health awareness and health-promoting behaviours of their parents/guardians, and especially that of the child’s mother. The aim of the study was to evaluate the knowledge of pregnant women regarding best practice oral hygiene procedures in young children. The survey involved 327 pregnant women aged 16-49 years, and the tool utilized was an anonymous questionnaire survey. The questionnaire included seven one-choice questions concerning basic information on proper oral hygiene procedures as should be practiced by young children. The statistical analysis was performed using Statistica PROGRAM 10 (StatSoft). The results of the survey reveal 60.55% of all surveyed had correct knowledge with regard to appropriate cleaning practices for the toothless oral cavity of an infant, that concerning the beginning of tooth brushing - 70.03%, tooth cleaning after night feeding - 39.76%, the duration of tooth brushing (at least 3-4 minutes) - 43.12%. What is more, the result of the survey demonstrate that slightly more than a half of the surveyed mothers (53.82%) would encourage their children to brush their teeth on their own from the first year of age, while 18.35% believe that children should be assisted in tooth brushing at least to their eighth year of age, and 59.63% would use fluoride toothpaste to brush their child’s teeth before he or she is one year old. Of the participants in this survey, pregnant women with university education, those living in large cities, or who are older, and those who had had previous pregnancies, show greater knowledge regarding suitable oral hygiene practices among young children. Our results reveal that extensive application of modern information technologies can be a means of preventing early childhood caries by facilitating the transmission of knowledge on proper nutrition and oral hygiene practices among young children.