bluuebunny/crossref_metadata_2025_split huggingface dataset:
A TOR-YAK1 signaling axis controls cell cycle, meristem activity and plant growth in Arabidopsis
Authors: Barrada Adam , Djendli Meriem , Desnos Thierry , Mercier Raphael , Robaglia Christophe , Montané Marie-Hélène , Menand Benoît 
Published: January 2019

ABSTRACT
TARGET OF RAPAMYCIN (TOR) is a conserved eukaryotic phosphatidylinositol-3-kinase-related kinase that plays a major role in regulating growth and metabolism in response to environment in plants. We performed a genetic screen for Arabidopsis ethylmethane sulfonate mutants resistant to the ATP-competitive TOR inhibitor AZD-8055 to identify new components of the plant TOR pathway. We found that loss-of-function mutants of the DYRK (dual specificity tyrosine phosphorylation regulated kinase)/YAK1 kinase are resistant to AZD-8055 and, reciprocally, that YAK1 overexpressors are hypersensitive to AZD-8055. Significantly, these phenotypes were conditional on TOR inhibition, positioning YAK1 activity downstream of TOR. We further show that the ATP-competitive DYRK1A inhibitor pINDY phenocopies YAK1 loss of function. Microscopy analysis revealed that YAK1 functions to repress meristem size and induce differentiation. We show that YAK1 represses cyclin expression in the different zones of the root meristem and that YAK1 is essential for TOR-dependent transcriptional regulation of the plant-specific SIAMESE-RELATED (SMR) cyclin-dependent kinase inhibitors in both meristematic and differentiating root cells. Thus, YAK1 is a major regulator of meristem activity and cell differentiation downstream of TOR.
Enhanced Quantum Yield of Nanographenes Incorporated in Supermicroporous Silicas and the Co-Adsorption Effect of Water Molecules
Authors: Watanabe Hiroto , Fujimaki Yasuto , Hayashi Kosei , Imai Hiroaki 
Published: January 2019

Abstract
Nanographene with various molecular sizes was synthesized and incorporated into the size-controlled pores of super-microporous silica (SMPS). It was found that when the pore diameter of the SMPS matched the molecular size of the nanographene, the fluorescence quantum yield was greatly enhanced. Furthermore, co-adsorption of water molecules improved the quantum yield. This improvement is attributed to a suppression of the interaction between the nanographene and silica walls, which lowers the quantum yield. Since nanographene is insoluble in water, it becomes surrounded by water molecules, almost like in aqueous solution. Finally, highly fluorescent solid materials were obtained by incorporating nanographene into SMPS.
Unicondylar knee arthroplasty using cobalt-chromium implants in patients with self-reported cutaneous metal hypersensitivity
Authors: Walker T. , Rutkowski L. , Innmann M. , Panzram B. , Herre J. , Gotterbarm T. , Aldinger P. R. , Merle C. 
Published: January 2019

Aims The treatment of patients with allergies to metal in total joint arthroplasty is an ongoing debate. Possibilities include the use of hypoallergenic prostheses, as well as the use of standard cobalt-chromium (CoCr) alloy. This non-designer study was performed to evaluate the clinical outcome and survival rates of unicondylar knee arthroplasty (UKA) using a standard CoCr alloy in patients reporting signs of a hypersensitivity to metal. Patients and Methods A consecutive series of patients suitable for UKA were screened for symptoms of metal hypersensitivity by use of a questionnaire. A total of 82 patients out of 1737 patients suitable for medial UKA reporting cutaneous metal hypersensitivity to cobalt, chromium, or nickel were included into this study and prospectively evaluated to determine the functional outcome, possible signs of hypersensitivity, and short-term survivorship at a minimum follow-up of 1.5 years. Results At a mean follow-up of three years (1.5 to 5.7), no local or systemic symptoms of hypersensitivity to metal were observed. One patient underwent revision surgery to a bicondylar prosthesis due to a tibial periprosthetic fracture resulting in a survival rate of 98.8% (95% confidence interval (CI) 91.7 to 99.8; number at risk, 28) at three years with the endpoint of revision for any reason and a survival rate of 97.6% (95% CI 90.6 to 99.3; number at risk, 29) for the endpoint of all reoperations. Clinical outcome was good to excellent with a mean Oxford Knee Score of 42.5 (sd 2.5; 37 to 48). Conclusion This study is the first demonstrating clinical results and survival analysis of UKA using a CoCr alloy in patients with a history of metal hypersensitivity. Functional outcome and survivorship are on a high-level equivalent to those reported for UKA in patients without a history of metal hypersensitivity. No serious local or systemic symptoms of metal hypersensitivity could be detected, and no revision surgery was performed due to an adverse reaction to metal ions.
A randomized, double-blind, placebo-controlled trial on the efficacy of tranexamic acid combined with rivaroxaban thromboprophylaxis in reducing blood loss after primary cementless total hip arthroplasty
Authors: Clavé A. , Gérard R. , Lacroix J. , Baynat C. , Danguy des Déserts M. , Gatineau F. , Mottier D. 
Published: January 2019

Aims Cementless primary total hip arthroplasty (THA) is associated with risks of bleeding and thromboembolism. Anticoagulants are effective as venous thromboprophylaxis, but with an increased risk of bleeding. Tranexamic acid (TXA) is an efficient antifibrinolytic agent, but the mode and timing of its administration remain controversial. This study aimed to determine whether two intravenous (IV) TXA regimens (a three-hour two-dose (short-TXA) and 11-hour four-dose (long-TXA)) were more effective than placebo in reducing perioperative real blood loss (RBL, between baseline and day 3 postoperatively) in patients undergoing THA who receive rivaroxaban as thromboprophylaxis. The secondary aim was to assess the non-inferiority of the reduction of blood loss of the short protocol versus the long protocol. Patients and Methods A multicentre, prospective, randomized, double-blind, placebo-controlled trial was undertaken involving 229 patients undergoing primary cementless THA using a posterior approach, whose extended rivaroxaban thromboprophylaxis started on the day of surgery. There were 98 male and 131 female patients, with a mean age of 65.5 years (32 to 91). The primary outcome, perioperative RBL, was evaluated at 72 hours postoperatively. The efficacy of short- and long-TXA protocols in the reduction of perioperative RBL was compared with a placebo group. Results TXA significantly reduced perioperative blood loss compared with placebo (p < 0.001); the mean differences were 525.3 ml (short-TXA vs placebo) and 550.1 ml (long-TXA vs placebo). No venous or arterial thromboembolic complications were reported. The upper boundary of the 95% confidence interval, when comparing short and long protocols, was below the pre-specified margin of non-inferiority (p = 0.027). Conclusion In patients undergoing primary cementless THA, using a posterior approach, who are treated with rivaroxaban for thromboembolic prophylaxis, short- and long-TXA IV protocols are significantly more effective than placebo in reducing perioperative RBL, without any thromboembolic complications. Non-inferiority of a short- versus a long-TXA protocol in reducing perioperative RBL was supported in a secondary analysis.
Fully integrated CMOS-compatible polarization analyzer
Authors: Wu Wenhao , Yu Yu , Liu Wei , Zhang Xinliang 
Published: January 2019

Abstract
Polarization measurement has been widely used in material characterization, medical diagnosis and remote sensing. However, existing commercial polarization analyzers are either bulky schemes or operate in non-real time. Recently, various polarization analyzers have been reported using metal metasurface structures, which require elaborate fabrication and additional detection devices. In this paper, a compact and fully integrated silicon polarization analyzer with a photonic crystal-like metastructure for polarization manipulation and four subsequent on-chip photodetectors for light-current conversion is proposed and demonstrated. The input polarization state can be retrieved instantly by calculating four output photocurrents. The proposed polarization analyzer is complementary metal oxide semiconductor-compatible, making it possible for mass production and easy integration with other silicon-based devices monolithically. Experimental verification is also performed for comparison with a commercial polarization analyzer, and deviations of the measured polarization angle are <±1.2%.
Crystal structure of 2-isopropylthioxanthone, C16H14OS
Authors: Liu Jin-Qiang , Ji Li , Wang Weizhou 
Published: January 2019

Abstract
C16H14OS, monoclinic, P21 (no. 4), a = 8.1588(5) Å, b = 7.8670(4) Å, c = 10.2161(5) Å, V = 655.70(6) Å3, Z = 2, R
gt(F) = 0.0539, wR
ref(F
2) = 0.1312, T = 290 K.
Amino acids and biogenic amines as food quality factors
Authors: Simon Sarkadi Livia 
Published: January 2019

AbstractThe importance of amino acids and biogenic amines is widely recognised in various fields, particularly in the fields of food science and nutrition. This mini-review contains a summary of my main research field that centres on aspects of Food Quality and Food Safety, with a particular emphasis on amino acids and biogenic amines. It also gives an overview of the recent developments on the related areas.
Syntheses and properties of cyclometalated ruthenium(II) complexes with 1,10-phenanthroline and phenylphthalazine ligands
Authors: Ji Jiao , Li Guo-Qiang , Xu Ya-Qin , Jia Ai-Quan , Zhang Qian-Feng 
Published: January 2019

Abstract
Treatment of cis-[RuCl2(phen)2]·2H2O (phen=1,- 10-phenanthroline) with 1-(2,6-diisopropylphenoxy)-4-phenylphthalazine (HL1) or 1-(2,6-dimethylphenoxy)-4-phenylphthalazine (HL2) in the presence of AgPF6 afforded two cyclometalated ruthenium(II) complexes, [Ru(κ
2-C,N-L1)(phen)2](PF6) (1) and [Ru(κ
2-C,N-L2)(phen)2](PF6) (2), respectively. The two complexes have been characterized by UV–vis and luminescence spectroscopy. The structure of 1·1.5H2O has been determined by single-crystal X-ray diffraction.
Competing Marxist Theories on the Temporal Aspects of Strike Waves: Silver’s Product Cycle Theory and Mandel’s Long Wave Theory
Authors: Cottle Eddie 
Published: January 2019

Despite the profound changes in capitalist development since the industrial revolution, strike waves and mass strikes are still a feature of the twenty-first century. This article examines two Marxist theories that seek to explain the temporal aspects of strike waves. In the main, I argue that Silver’s product cycle theory, suffers from an over-determinism, and that turning point strike waves are not mainly determined by lead industries. Mandel’s long wave theory argues that technological innovations tend to cluster and thus workers in different industries feature prominently in strike waves. By re-examining and comparing two competing Marxist theories on the temporality of strike waves and turning points, I will attempt to highlight the similarities but also place emphasis on where the theories differ. I examine the applicability of the theories to the South African case, and reference recent world events in order to ascertain the explanatory power of the competing theories. In the main I argue that Silver’s product cycle lead theory does not fit the South African experience.
KEYWORDS turning point strike waves; product cycle; long waves; capitalism
Interference Effects of Deleterious and Beneficial Mutations in Large Asexual Populations
Authors: Jain Kavita 
Published: January 2019

Abstract
Linked beneficial and deleterious mutations are known to decrease the fixation probability of a favorable mutation in large asexual populations. While the hindering effect of strongly deleterious mutations on adaptive evolution has been well studied, how weakly deleterious mutations, either in isolation or with superior beneficial mutations, influence the rate of adaptation has not been fully explored. When the selection against the deleterious mutations is weak, the beneficial mutant can fix in many genetic backgrounds, besides the one it arose on. Here, taking this factor into account, I obtain an accurate analytical expression for the fixation probability of a beneficial mutant in an asexual population at mutation-selection balance. I then exploit this result along with clonal interference theory to investigate the joint effect of linked beneficial and deleterious mutations on the rate of adaptation, and identify parameter regions where it is reduced due to interference by either beneficial or deleterious or both types of mutations. I also study the evolution of mutation rates in adapting asexual populations, and find that linked beneficial mutations have a stronger influence than the deleterious mutations on mutator fixation.
Infant out-of-Hospital Mortality and Ways to Reduce It
Authors: Kryuchko Daria S. , Ryumina Irina I. , Chelysheva Vera V. , Sokolova Ekaterina V. , Baibarina Elena N. 
Published: January 2019

Infant mortality is one of the key indicators of demography, characterizing not only the state of health and a social standard of living in a country, region, city, but also an indicator of the level of state development. In recent years there has been a steady downward trend in infant mortality. To the greatest extent, this trend is driven by improved quality of medical care. However, death of children outside healthcare facilities is the least controlled in the structure of infant mortality. The article considers the main causes of deaths of children under the age of one year outside healthcare facilities in the Russian Federation in 2017, presents data of the world and national statistics, analyses possible solutions to the problem.
Criteria for Differentiation of Non-Bacterial and Haematogenous Osteomyelitis: A Case-Control Study With Prospective Verification of the Outcomes
Authors: Kostik Mikhail M. , Kopchak Olga L. , Taschilkin Alexey I. , Zorin Vyacheslav I. , Maletin Alexey S. , Mushkin Alexander Yu. 
Published: January 2019

Background. Patients with haematogenous and non-bacterial osteomyelitis have similar clinical symptoms (pain in the nidus area, soft tissue swelling, fever) and laboratory signs (increased erythrocyte sedimentation rate, leukocyte count, C-reactive protein concentration). The criteria for distinguishing these two states are not determined.Objective. Our aim was to determine diagnostic criteria to differentiate haematogenous and non-bacterial osteomyelitis.Methods. The study included data of patients under the age of 18 years with non-bacterial or haematogenous osteomyelitis hospitalised to two clinical centres from 2009 to 2016. The diagnosis was established and re-verified according to archival data (medical history) and after two years of observation (at least once a year). Clinical, anamnestic and laboratory data (haemoglobin, leukocytes, leukocyte formula, platelets, ESR and C-reactive protein, CRP) as well as the results of radiation diagnostics (X-ray, CT scan, MRI or osteosyntigraphy) obtained at the disease onset were taken into account as potential diagnostic criteria.Results. Out of 145 patients with non-bacterial or haematogenous osteomyelitis, the diagnosis was re-verified in 138, of them non-bacterial osteomyelitis — in 91, haematogenous osteomyelitis — in 47. The following criteria had the highest diagnostic value for establishing cases of non-bacterial osteomyelitis: detection of bone destruction foci surrounded by osteosclerosis area [sensitivity (Se) 1.0; specificity (Sp) 0.79]; absence of fever (Se 0.66; Sp 0.92); the number of bone destruction foci > 1 (Se 0.73; Sp 1.0); CRP 55 mg/L (Se 0.94; Sp 0.73); negative results of bacteriological examination of the material from the bone destruction focus (Se 1.0; Sp 0.67).Conclusion. Diagnostic criteria for differentiation of non-bacterial and haematogenous osteomyelitis have been described. Further research on the efficacy of using these criteria to reduce the risk of diagnostic errors, decrease the diagnostic pause, reduce the risk of non-bacterial osteomyelitis complications is needed.
Nutritional Support for a Child With Juvenile Myelomonocytic Leukaemia at Various Stages of Antineoplastic Therapy: A Clinical Case
Authors: Shamsutdinova Mariam S. , Alymova Yulia A. , Vashura Andrey Yu. 
Published: January 2019

Background. Juvenile myelomonocytic leukaemia is a malignant disease with clonal impairment of haematopoiesis, characterized by excessive proliferation of monocytic and granulocytic sprout. Currently, the only way to cure it is hematopoietic stem cell transplantation. Vigorous treatment is accompanied by the development of a large number of complications, including nutritional ones. Nutritional support for these patients is fraught with many difficulties due to the treatment characteristics, patient’s condition, and complications of therapy.Description of a Clinical Case. A child diagnosed with juvenile myelomonocytic leukaemia, 1 year and 11 months old, received antineoplastic therapy — chemotherapy and bone marrow transplantation. In the course of treatment and after it, severe complications developed, which required various types of nutritional support, depending on the clinical situation. It is illustrated how important timely nutritional support is and how long and difficult nutritional disorders can proceed in these children even after termination of the main therapy.Conclusion. Preventive nutritional support with infant formulas is advisable for children with oncological diseases prior to treatment even with normal nutritional indicators. With the potential long-term impossibility of adequate alimentation per os, it is advisable to consider the placement of a gastrostomy tube for enteral nutrition since problems with appetite can be very long.
Ethical aporia of organ donation development
Authors: Popova O. V. 
Published: January 2019

Aim.The Aim of the article is to investigate the ethical and epistemological problems that have arisen in recent years in connection with the emergence of incidents that have caused the problematization of traditional approaches to the definition and ascertainment of death (in particular, cases that reflect the history of Jahi McMath and Anahita Meshkin) and the spread in the West such practices, as «controlled donation» and «donation after euthanasia».Materials and methods.The article uses the method of socio-ethical analysis and the bioethical case study methodology.Results.The analysis of the development of ethical support for the practice of organ donation is presented.Conclusion.The conclusion is made about the pronounced liberalization of the ethics of organ donation, characterized by the dictates of local moral contingency, linguistic manipulations with the categories of «gift», «harm», «autonomy» and the threat of trends in technological instrumentality in the system of development of transplantology and organ donation with the initial minimum of ethical grounds.
Lung transplantation for idiopathic pulmonary arterial hypertension: perioperational features
Authors: Poptsov V. N. , Spirina E. A. , Pashkov I. V. , Belikova A. V. , Oleshkevich D. O. , Latipov R. A. , Tsirulnikova O. M. , Epremian A. C. , Shigaev E. F. , Gautier S. V. 
Published: January 2019

Lung transplantation (LT) for idiopathic pulmonary arterial hypertension (IPAH) now is the only radical treatment of this disease.Aim:to analyze own experience of performing LT in patients with IPAH.Materials and methods.8 adult IPAH patients, who underwent LT between 2014 and october 2018, were included. In 7 of 8 patients undergoing bilateral lung transplantation on intraoperative venoarterial extracorporeal membrane oxygenation (VA ECMO) with prolongation into the postoperative period.Results.VA ECMO support was prolonged into postoperative period 6 and 7 days respectively in 2 (25,0%) patients and 3 days in 6 (75,0%) patients. Hospital mortality in IPAH patients was 1.Conclusions.Own experience demonstrates that LT is an effective method of treatment in patients with IPAH. Hospital, 1- and 3-year survival rates for the patient collective were 87.5, 75.0 and 75.0% respectively.
МАГМАТИЗМ И ЭПИТЕРМАЛЬНОЕ Ag-Au ОРУДЕНЕНИЕ КРАСНОЯРСКОГО РУДНОГО ПОЛЯ ГОРНОГО АЛТАЯ
Authors: (Anatoliу I. Gusev) Гусев Анатолий Иванович , (Evgeniya M. Tabakaeva) Табакаева Евгения Михайловна 
Published: January 2019

Актуальность исследования определяется необходимостью освещения новых данных по петрологии, геохимии субвулканических пород и эпитермальному Ag-Au оруденению Красноярского рудного поля Горного Алтая. С субвулканическими штоками гранитоидов пространственно и парагенетически связаны различные типы оруденения: меди, кобальта, мышьяка, вольфрама и золота. Впервые для Горного Алтая исследован высоко-серный тип Ag-Au оруденения. Цель исследования: изучить петрологические, геохимические особенности пород и оруденения Красноярского месторождения с использованием экспериментальных диаграмм, позволяющих выявлять генетические проблемы и физико-химические особенности петро-рудогенезиса. Методы исследования включали изучение состава горных пород с применением лазерно-абляционного анализа методом индуктивно-связанной плазмы на спектрометре «ОРTIMA&4300» с высокой чувствительностью определения элементов в Лаборатории Института минералогии, геохимии и кристаллохимии редких элементов (г. Москва). Изотопный состав серы и кислорода определён на масс-спектрометре МИ 1201В в той же лаборатории. Результаты. Главными рудогенерирующими объектами в Красноярском рудном поле являются субвулканические штоки гранитоидов среднего девона коргонского комплекса, которые относятся к пералюминиевому типу с варьирующими характеристиками по магнию и железу. В породах проявлен тетрадный эффект фракционирования РЗЭ W-типа. Концентрации Au и Ag в породах увеличиваются с уменьшением величины тетрадного эффекта фракционирования РЗЭ W-типа. Глубинный магматический очаг эволюционировал в сторону повышения его уровня с формированием резко кислотно-серных характеристик и формированием околорудных аргиллизитов. Оруденение Красноярского месторождения представлено серией сближенных кварцевых жил, с образованием своеобразного линейного штокверка. Руды сформированы в три стадии: существенно сульфидную, теллуридную и пострудную. Основные рудные минералы: пирит, галенит, сфалерит, тетраэдрит, теннантит, электрум, тетрадимит, редко – алтаит, гессит, энаргит, люцонит. Основные жильные минералы: кварц, кальцит, хлорит, сидерит, каолинит, монтмориллонит, иллит. Концентрации золота в рудах варьируют от 0,5 до 29,6 г/т, серебра – от 15 до 5000 г/т. Соотношение Ag/Au в рудах варьирует от 135 до 150 и позволяет относить Красноярское месторождение к Ag-Au типу. Температуры гомогенизации газово-жидких включений в кварце разных генераций от стадии к стадии снижались от 265 до 175 °С. Фугитивность серы снижалась от первой стадии (–10–11) ко второй (–15–16), f Te2 повышалась от (–15) до (–10) и f О2 от (–39,5) до (–37). Изотопы серы и кислорода свидетельствуют о магматогенном источнике серы и метеорном – кислорода.