bluuebunny/crossref_metadata_2025_split huggingface dataset:
A emergência da profissão do Educador Social: uma aproximação a partir dos processos de profissionalização
Authors: Canastra Fernando Augusto Coelho 
Published: June 2019

A formação inicial dos Educadores Sociais, em Portugal, tende a ins-crever-se numa lógica difusa, tanto ao nível do perfil formativo-profis-sional, como ao nível do seu referente competencial. O propósito destacomunicação visa apresentar uma aproximação a um modelo formativo,tendo como matriz disciplinar específica a Pedagogia Social. Partindode um referencial de competências (Sáez, 2009), sugerimos uma ou-tra abordagem em relação à consolidação do exercício profissional dosEducadores Sociais. A crescente oferta formativa nesta área, ao nível doensino superior, exige que se produzam referentes partilhados no do-mínio conceptual, metodológico e deontológico. Caso contrário, a lógi-ca de “desprofissionalização” tenderá a impor-se nos diversos sectores de intervenção onde trabalha o(a) Educador(a) Social. A formação dosprofissionais de Educação Social deve centrar-se numa lógica profissio-nal. É a partir deste enfoque que temos vindo a investigar.
Factors associated with follow-up difficulty in longitudinal studies involving community-dwelling older adults
Authors: Kawai Hisashi , Ejiri Manami , Tsuruta Harukazu , Masui Yukie , Watanabe Yutaka , Hirano Hirohiko , Fujiwara Yoshinori , Ihara Kazushige , Tanaka Masashi , Obuchi Shuichi 
Published: June 2019

Abstract
Background

To clarify the factors associated with the gradual drop-out from society in older adults, we defined the stages of follow-up difficulty based on four follow-up surveys on non-respondents of longitudinal mail surveys in community-dwelling older adults. This study aimed to examine the main factors associated with the stages of follow-up difficulty.

Methods

We conducted a follow-up mail survey (FL1) aimed at the baseline respondents and conducted follow-up surveys on non-respondents of each survey as follows; simplified mail (FL2), post card (FL3), and home visit surveys (FL4). The respondents of each follow-up survey were defined as a stage of follow-up difficulty and their characteristics concerning social participation and interaction at the baseline in each stage were analyzed.

Results

The respondent numbers of the FL1, FL2, FL3, and FL4 and NR (non-respondents) stages were 2,361; 462; 234; 84; and 101 respectively. Participation in hobby groups for FL2 and FL3, in sports groups in FL4, and for the neighborhood association and social isolation in NR were significantly associated with the stage of follow-up difficulty.

Conclusions

Based on these results, we conclude that the factors associated with each stage of follow-up difficulty are: 1) their activities start to be restricted by a decline in IADL in the FL2 and FL3 stages, 2) they dislike taking part in physical activity such as sports in the FL4 stage, and 3) they are more socially isolated, not belong to even a neighborhood association owing to be low social interaction in the NR group.
Whole-transcriptome analysis of heart in bovidae reveals regulatory pathways associated with high-altitude adaptation
Authors: Wang Hui , Zhixin Chai , Jincheng Zhong , Zhi Chen , Jiangjiang Zhu , Jikun Wang , Chengfu Zhang , Hanwen Cao , Jinwei Xin 
Published: June 2019

Abstract
Background: the yak (Bos grunniens) is one of the major livestock that can survive the extremely cold, harsh and oxygen-poor conditions and provide meat, milk and transportation for Tibetans living in the Qinghai-Tibetan Plateau, and there are some cattle migrate to yak habitat but cannot survive the extremely conditions well. However, the regulatory mechanisms that drive hypoxic adaptation of yak remain elusive.
Results: Thus, we collected heart tissues from Leiwuqi (LWQ) yak and their relatives, the migration cattle in LWQ yak habitat (HAC) and low-altitude cattle (LAC), respectively, for RNA sequencing, 178 co-differentially expressed protein-coding transcripts (CETs) including 6 down-regulated and 172 up-regulated CETs were discovered in both LAC-vs-LWQY and LAC-vs-HAC comparison groups. There were 133, 11 and 3 lncRNA transcripts were specific expressed in LWQY, HAC, and LAC groups, respectively. 2 and 230 lncRNA transcripts differentially expressed in LAC-vs-LWQY and LAC-vs-HAC，respectively, but no lncRNA transcripts co-differentially expressed in those two comparison groups. Among the 58 miRNAs that were co-differentially expressed, 18 were up-regulated and 40 were down-regulated. In addition, 640 (501 up-regulated and 139 down-regulated) and 152 (152 up-regulated and 1 down-regulated) circRNAs showed differential expression in LAC-vs-LWQY and LAC-vs-HAC comparison groups, respectively, and 53 up-regulated co-differentially expressed circRNAs were shared. Multiply CETs which are the target genes for miRNAs/lncRNAs were significantly enriched in high-altitude adaptation related processes, for instance, T cell receptor signaling, VEGF signaling, and cAMP signaling. A competing endogenous RNA (ceRNA) network by integrating competing relationships among CETs, miRNAs, lncRNAs and circRNAs were constructed. Furthermore, we constructed a hypoxic adaptation related ceRNA network to identified that 8 miRNAs and 15 circRNAs were predicted to regulated MAPKAPK3, PXN, NFATC2, ATP7A, DIAPH1 and F2R genes.
Conclusion: In conclusion, our data reinforce the view that the molecular network of high-altitude adaptation is composed of several protein-coding transcripts and non-coding transcripts that involved in multiply hypoxic adaptation regulatory pathways. The detailed mechanism for how this network crosstalk each other in heart of Bovidae are worthy of future research efforts.
Combined GLP-1, Oxyntomodulin, and Peptide YY Improves Body Weight and Glycemia in Obesity and Prediabetes/Type 2 Diabetes: A Randomized, Single-Blinded, Placebo-Controlled Study
Authors: Behary Preeshila , Tharakan George , Alexiadou Kleopatra , Johnson Nicholas , Wewer Albrechtsen Nicolai J. , Kenkre Julia , Cuenco Joyceline , Hope David , Anyiam Oluwaseun , Choudhury Sirazum , Alessimii Haya , Poddar Ankur , Minnion James , Doyle Chedie , Frost Gary , Le Roux Carel , Purkayastha Sanjay , Moorthy Krishna , Dhillo Waljit , Holst Jens J. , Ahmed Ahmed R. , Prevost A. Toby , Bloom Stephen R. , Tan Tricia M. 
Published: June 2019

OBJECTIVE
Roux-en-Y gastric bypass (RYGB) augments postprandial secretion of glucagon-like peptide 1 (GLP-1), oxyntomodulin (OXM), and peptide YY (PYY). Subcutaneous infusion of these hormones (“GOP”), mimicking postprandial levels, reduces energy intake. Our objective was to study the effects of GOP on glycemia and body weight when given for 4 weeks to patients with diabetes and obesity.

RESEARCH DESIGN AND METHODS
In this single-blinded mechanistic study, obese patients with prediabetes/diabetes were randomized to GOP (n = 15) or saline (n = 11) infusion for 4 weeks. We also studied 21 patients who had undergone RYGB and 22 patients who followed a very low-calorie diet (VLCD) as unblinded comparators. Outcomes measured were 1) body weight, 2) fructosamine levels, 3) glucose and insulin during a mixed meal test (MMT), 4) energy expenditure (EE), 5) energy intake (EI), and 6) mean glucose and measures of glucose variability during continuous glucose monitoring.

RESULTS
GOP infusion was well tolerated over the 4-week period. There was a greater weight loss (P = 0.025) with GOP (mean change −4.4 [95% CI −5.3, −3.5] kg) versus saline (−2.5 [−4.1, −0.9] kg). GOP led to a greater improvement (P = 0.0026) in fructosamine (−44.1 [−62.7, −25.5] µmol/L) versus saline (−11.7 [−18.9, −4.5] µmol/L). Despite a smaller weight loss compared with RYGB and VLCD, GOP led to superior glucose tolerance after a mixed-meal stimulus and reduced glycemic variability compared with RYGB and VLCD.

CONCLUSIONS
GOP infusion improves glycemia and reduces body weight. It achieves superior glucose tolerance and reduced glucose variability compared with RYGB and VLCD. GOP is a viable alternative for the treatment of diabetes with favorable effects on body weight.
Association of Habitual Daily Physical Activity With Glucose Tolerance and β-Cell Function in Adults With Impaired Glucose Tolerance or Recently Diagnosed Type 2 Diabetes From the Restoring Insulin Secretion (RISE) Study
Authors: Temple Karla A. , Tjaden Ashley H. , Atkinson Karen M. , Barengolts Elena , Hannon Tamara S. , Mather Kieren J. , Utzschneider Kristina M. , Edelstein Sharon L. , Ehrmann David A. , Mokhlesi Babak ,   RISE Consortium Investigators, Zeitler Philip S. , Williams Jayne , Cree-Green Melanie , Reyes Yesenia Garcia , Vissat Krista , Ehrmann David A. , Temple Karla A. , Rue Abby , Barengolts Elena , Mokhlesi Babak , Van Cauter Eve , Sam Susan , Miller M. Annette , Kahn Steven E. , Atkinson Karen M. , Palmer Jerry P. , Utzschneider Kristina M. , Gebremedhin Tsige , Kernan-Schloss Abigail , Kozedub Alexandra , Montgomery Brenda K. , Morse Emily J. , Mather Kieren J. , Garrett Tammy , Hannon Tamara S. , Lteif Amale , Patel Aniket , Chisholm Robin , Moore Karen , Pirics Vivian , Pratt Linda , Nadeau Kristen J. , Gross Susan , Savage Peter J. , Leschek Ellen W. , Arslanian Silva A. , Brown Kathleen , Guerra Nancy , Porter Kristin , Caprio Sonia , Savoye Mary , Pierpont Bridget , Buchanan Thomas A. , Xiang Anny H. , Trigo Enrique , Beale Elizabeth , Hendee Fadi N. , Katkhouda Namir , Nayak Krishan , Martinez Mayra , Montgomery Cortney , Wang Xinhui , Edelstein Sharon L. , Lachin John M. , Tjaden Ashley H. , Marcovina Santica , Harting Jessica , Albers John , Hill Dave 
Published: June 2019

OBJECTIVE
We examined the relationship between habitual daily physical activity and measures of glucose tolerance, insulin sensitivity, and β-cell responses in adults with impaired glucose tolerance (IGT) or drug-naive, recently diagnosed type 2 diabetes.

RESEARCH DESIGN AND METHODS
Participants included 230 adults (mean ± SD age 54.5 ± 8.5 years, BMI 35 ± 5.5 kg/m2; 42.6% women) who underwent a 3-h oral glucose tolerance test (OGTT) and hyperglycemic clamp. Wrist accelerometers worn for 7 consecutive days measured total physical activity counts (TAC) (daily mean 233,460 [∼50th percentile for age]). We evaluated whether TAC was associated with fasting plasma glucose, OGTT 2-h plasma glucose or glucose incremental area under the curve (G-iAUC), hyperglycemic clamp measures of insulin sensitivity (steady-state glucose infusion rate/insulin [M/I]) and β-cell responses (acute C-peptide response to glucose, steady-state C-peptide, and maximal β-cell response), and OGTT C-peptide index (ΔC-peptide0–30/Δglucose0–30).

RESULTS
After adjustments for confounders, there was no association of TAC with fasting plasma glucose, 2-h glucose, or G-iAUC. Higher TAC was associated with higher insulin sensitivity (M/I). After adjusting for M/I, higher TAC was not associated with measures of β-cell response.

CONCLUSIONS
In adults with IGT or drug-naive, recently diagnosed type 2 diabetes, higher levels of habitual physical activity are associated with higher insulin sensitivity. Further studies are needed to understand why higher levels of physical activity are not associated with better β-cell response.
Pemberian Dosis Pupuk Kandang dan Interval Panen terhadap Produksi Jawer Kotok (Coleus atropurpureus L. Benth)
Authors: Ayunina Krisetya , Aziz Sandra Arifin 
Published: June 2019

Jawer Kotok merupakan tanaman obat yang berasal dari Indonesia. Tanaman ini memiliki berbagai khasiat untuk kesehatan, tetapi belum banyak diketahui dan dibudidayakan sebagai tanaman obat. Produksi Jawer Kotok yang optimum memerlukan pertimbangan dari segi produktivitas tanaman serta bahan aktif yang terkandung di dalamnya. Budidaya tanaman obat umumnya dilakukan secara organik untuk menghindari pengaruh bahan kimia pada senyawa bioaktif dalam tanaman. Penelitian ini dilakukan untuk mengetahui dosis pupuk kandang dan interval panen yang dapat menunjang produksi Jawer Kotok sebagai tanaman obat. Penelitian dilaksanakan di Kebun Percobaan Cikabayan, Bogor, Jawa Barat, Indonesia pada bulan Januari hingga Juli 2018. Rancangan lingkungan yang digunakan adalah Rancangan Kelompok Lengkap Teracak dengan tiga ulangan. Hasil penelitian menunjukkan bahwa dosis pupuk signifikan meningkatkan bobot basah batang total serta variabel pertumbuhan berupa pertambahan tinggi tanaman, lebar tajuk dan jumlah cabang. Interval panen yang sering signifikan menurunkan bobot basah daun total dan variabel pertumbuhan berupa jumlah daun, pertambahan tinggi tanaman, lebar tajuk, jumlah cabang, kadar air, dan persentase daun batang. Interval panen signifikan menurunkan kadar klorofil a, karoten, dan total klorofil daun. Terdapat interaksi antara dosis pupuk dan interval panen pada parameter pertambahan tinggi tanaman pada 10 dan 26 MST.
Outcome of Injection Sclerotherapy for First Degree and Second Degree Haemorrhoids– A Study of 50 Cases
Authors: Quadir Md Ershad Ul , Rahman Md Mahbubur , Islam Md Tanvirul , Hosssain SM Shakhawat 
Published: June 2019

Introduction: Haemorrhoid is the frequent problem in clinical practice of general surgery. Haemorrhoids are dilatation and tortuosity of rectal veins affecting almost 4.5% of the population. Various operative and non operative therapeutic options are in practice to treat haemorrhoids, yet none has been proven cent percent effective. Sclerotherapy is a simple, safe and cost effective procedure that is widely practiced globally to treat haemorrhoids. Many sclerosants are being used with variable efficacies.
Objective: To evaluate the outcome of injection Sclerotherapy in first degree and second degree haemorrhoids.
Materials and Methods: Fifty patients of both gender having haemorrhoids who attended Outpatient Department (OPD) at BNS Patenga from September 2013 to August 2014 were included in this study. On the basis of history, patients were selected for Digital Rectal Examination (DRE) and proctoscopic examination to confirm the diagnosis. Sclerotherapy was repeated at interval of 6 weeks till symptomatic relief was achieved. Maximum 3 sittings of sclerotherapy were given. Patients were followed up at 3 months interval for 1 year.
Results: This prospective study was conducted on 50 cases of first degree and second degree Haemorrhoids. The highest number of patients 21(42%) were in the age group of 21-30 years with majority 38(76%) being male. Male female ratio was 3.16: 1. All the patients presented with painless per-rectal bleeding. Satisfactory results were observed in 29(58%) patients of whom 20(40%) patients were having first degree haemorrhoids and 9(18%) patients were having second degree haemorrhoids. Sclerotherapy was more effective in first degree compared to second degree haemorrhoids patients.
Conclusion: Injecting Sclerotherapy is a suitable office procedure for treatment of haemorrhoids. The method is easy, convenient, cheap, well accepted and comfortable for patient. More or less there are no complications and the result is also satisfactory.
Journal of Armed Forces Medical College Bangladesh Vol.12(2) 2016: 98-101
Competências digitais na perspectiva da informação, conhecimento e aprendizagem
Authors: Rocha Paulo César da Silva , Jucá Sandro César Silveira , Silva Solonildo Almeida da , Monteiro Aldayr de Oliveira 
Published: June 2019

Este artigo tem como objetivo identificar as competências digitais exigidas na sociedade contemporânea, dentro da perspectiva de seu uso na educação. Pode-se afirmar que na sociedade atual, que é amparada na informação, conhecimento e aprendizagem, num cenário de constantes e complexas mudanças impulsionadas pelo avanço da tecnologia, é importante que haja indivíduos preparados para fazer parte desse processo. Nota-se, para Rocha, Jucá e Silva (2019), um esforço contínuo de inovações humanas para transmitir ideias e criações ao longo do tempo e do espaço. Para esse artigo foi realizado uma pesquisa qualitativa, que, de acordo com Minayo (2007) possibilita ao pesquisador uma análise aprofundada do objeto estudado. Inicialmente, foi utilizada a pesquisa exploratória, na busca de bases teóricas por meio de uma revisão da literatura. Podemos concluir, a partir do exposto refere-se aos benefícios potenciais das TIC para o ensino-aprendizagem, incluindo ganhos na realização e motivação dos alunos. Acrescenta-se ainda a possibilidade de acessar um conteúdo dos quais não há oferta presencialmente, o que seja mais cômodo acessar de forma online. O segundo argumento reconhece a onipresença das tecnologias, o que leva à necessidade subsequente de adquirir a competência digital para ser funcional na sociedade, já que diversos serviços estão disponíveis na modalidade digital. Como consequência, o terceiro argumento enfatiza a necessidade de investir no aprimoramento das habilidades digitais para o crescimento social e competitividade econômica.
Desafios da construção e consolidação dos mestrados profissionais na área de Ensino no Brasil
Authors: Rocha Paulo César da Silva , Oliveira Maria das Graças de , Jucá Sandro César Silveira , Silva Solonildo Almeida da 
Published: June 2019

Este artigo tem como objetivo expor alguns desafios decorrentes da construção e consolidação dos mestrados profissionais na área de Ensino no Brasil. Existe ainda, por parte das instituições, uma falsa percepção de que o mestrado profissional pode desaboná-las e que apenas os programas acadêmicos dão prestígio e promovem a qualificação da universidade, o que representa um equívoco. Em detrimento desta equivocada percepção, traz-se documentos como os Programas da Área de Educação da Capes que estão organizados em diferentes propostas, constituindo linhas de pesquisa específicas e dando prioridade a produção de conhecimento educacional. Por meio de pesquisa qualitativa de caráter exploratório, chega-se a conclusão de que a diversidade na identidade dos mestrados profissionais não está apenas determinada pela sua área temática, mas, fundamentalmente, pelo grande desafio de integração com rigor a pesquisa no seu processo de desenvolvimento e conseguir a aplicabilidade dos resultados para transformação da realidade estudada. A partir do exposto, consideramos que o materialismo histórico-dialético pode contribuir para o entendimento epistemológico nas investigações sobre práticas em espaços educativos, pois suas dimensões ontológicas, axiológicas e gnosiológicas integram uma filosofia da transformação, a qual visa, por meio da análise histórica e dialética da realidade, alcançar sínteses que retomem, em outra dimensão, a conhecimento inicial, e visam, em última estância, à transformação social e coletiva.
About Stamped Paper of Shevchenko’s Release
Authors: Boron Oleksandr 
Published: June 2019

The author focused on examining various references concerning the amount paid to P. Engelgardt for the liberation of T. Shevchenko from serfdom. The article explains why the release was issued on the stamped paper for the transactions worth up to 1000 rubles, although the freedom of the poet cost 2500 rubles in banknotes.
Nonlinear compression of high-power laser pulses: compression after compressor approach
Authors: Khazanov E A , Mironov S Yu , Mourou G 
Published: June 2019

Abstract
The peak power of present-day lasers is limited by the pulse energy that the diffraction gratings of an optical compressor can withstand. A promising method to overcome this limitation is reviewed: the pulse power is increased by shortening its duration rather than increasing the pulse energy, the pulse being shortened after passing a compressor (Compression after Compressor Approach (CafCA)). For this purpose, the pulse spectrum is broadened as a result of self-phase modulation, and the pulse is then compressed by dispersion mirrors. Application of this idea, known since the 1960s, to lasers whose power is over 1 TW has been restrained until recently by a number of physical problems. These problems and possible methods to solve them are discussed in detail. The experimental results obtained over the past few years demonstrate the efficiency of the technique (compression by a factor of 5) in the range up to 250 TW. CafCA features three undisputed merits: simplicity and low cost, negligible loss of pulse energy, and applicability to any high-power laser.
Comparison of Added Value between Bioethanol Production and the Most Important Animal Production Branches Based on Concentrated Fodder, as Potential Competitors
Authors: Péter Jobbágy  
Published: June 2019

There are an enormous amount (2-3 million t/yr) of corn surplus is available year by year in Hungary. Inland utilization is an unsolved problem, whereas export facilities of raw (unprocessed) material could not be regarded as optimal way because of logistical barriers and the very low producer’s price. There are two basic opportunities for the export of the surplus of maize with reduced transportational costs and higher value: animal production and process of bio-ethanol. In Hungarian conditions both of them demand the same raw material so they should compete with each other for maize. Both need financial aid at least for the investment in order to reach profit. Decision makers are influenced by several factors in allocating of national supports between the differential branches, one of them could be the added value developing in the given vertical change. I will introduce and analyze the expectable added values of the abovementioned competitive activities.
L’hôpital public : par pertes et profits
Authors: Juven Pierre-André 
Published: June 2019

L’hôpital public va mal. Même la ministre de la Santé Agnès Buzyn en convient, elle qui déclarait : « L’hôpital entreprise, c’est fini » en annonçant à la fin 2017 la mise en place de la commission Aubert, chargée de faire des propositions. Pierre-André Juven revient ici sur la place qu’a prise l’hôpital dans le système de santé français. À l’encontre des pourfendeurs de l’hospitalo-centrisme, ne voyant dans la crise que la conséquence d’une accumulation de tâches et de moyens qui lui sont dévoués, il rappelle que les nouveaux modes de gestion et de financement l’ont progressivement étouffé. Mais il plaide aussi pour une critique qui n’oublie pas que s’il faut effectivement débloquer des moyens publics pour résorber la dette, financer les centres de santé et les structures de proximité, et revaloriser les salaires les plus bas à l’hôpital, il est tout aussi urgent de réfléchir à la façon dont on y travaille, et pour répondre à quels besoins.
« La crise sanitaire est la quatrième crise écologique »
Authors: Gaudillière Jean-Paul 
Published: June 2019

Chimiste, toxicologue, chercheur en santé environnementale, spécialiste de l’évaluation des risques sanitaires, André Cicolella a travaillé de 1971 à 1994 à l’Institut national de recherche et de sécurité (INRS) – d’où il a été abusivement licencié alors qu’il organisait un symposium international sur les effets des éthers de glycol sur la santé – puis à l’Institut national de l’environnement industriel et des risques (INERIS). Il a milité pour la protection juridique des lanceur.ses d’alerte et contribué à la création en 2001 de l’Agence française de sécurité sanitaire de l’environnement (et depuis 2005, du travail, AFSSET). Il a été le premier président de la Fondation Sciences Citoyennes, de 2002 à 2007. Il revient ici sur le bilan et sur la stratégie du Réseau Environnement Santé fondé en 2009, qui cherche à favoriser le développement de la santé environnementale comme réponse à la crise sanitaire.