bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association of perioperative P2Y12 inhibitor administration with outcomes for tandem occlusion: RESCUE AT-LVO sub-study
Authors: Yoshimoto Takeshi , Yamagami Hiroshi , Sakai Nobuyuki , Uchida Kazutaka , Shirakawa Manabu , Beppu Mikiya , Toyoda Kazunori , Matsumaru Yuji , Matsumoto Yasushi , Todo Kenichi , Hayakawa Mikito , Shindo Seigo , Morimoto Masafumi , Takeuchi Masataka , Imamura Hirotoshi , Ikeda Hiroyuki , Tanaka Kanta , Ishihara Hideyuki , Kakita Hiroto , Sano Takanori , Araki Hayato , Nomura Tatsufumi , Sakakibara Fumihiro , Yoshimura Shinichi ,   for RESCUE AT-LVO Investigators
Published: November 2024

BackgroundWe aimed to clarify the association between intraoperative P2Y12 inhibitor administration during EVT and clinical outcomes in patients with anterior circulation TO stroke.MethodsAmong consecutive patients with acute ischemic stroke (AIS) enrolled in the Recovery by Endovascular Salvage for Cerebral Ultra-acute Embolic and Atherothrombotic Stroke with Large Vessel Occlusion Registry from 2016 to 2019, those with anterior circulation TOs who underwent EVT were analyzed. These patients were categorized into the following groups: those who received P2Y12 inhibitors during the perioperative period and those who did not receive P2Y12 inhibitors. The outcomes included good functional outcomes, as indicated by a modified Rankin Scale score of 0–2 at 90 days, and the incidence of symptomatic intracranial hemorrhage (SICH) was compared between the two groups. Multivariate logistic regression models were used to assess the association of outcomes with perioperative P2Y12 inhibitor administration. Odds ratios (ORs) with 95% confidence intervals (CIs) were calculated using the group that did not receive P2Y12 inhibitors as the reference. The perioperative period included the period in which antithrombotic therapy was administered immediately before EVT and during the operative period.ResultsWe enrolled 242 patients with AIS with anterior circulation TOs (42 females [17.4%]; median age, 76 [interquartile range, 69–81] years). Patients who received P2Y12 inhibitors during the perioperative period (n = 131) showed a higher frequency of carotid artery stenting than those who did not receive perioperative P2Y12 inhibitors (n = 111; 86.3% vs. 42.3%, p &lt; 0.01). Furthermore, patients who received perioperative P2Y12 inhibitors during the perioperative period had a higher incidence of good functional outcomes than those who did not receive perioperative P2Y12 inhibitors (42.0% vs. 32.4%; adjusted OR: 6.65, 95% CI: 1.88–23.53), with no significant differences between the groups in the incidence of SICH (5.3% vs. 8.1%; OR: 0.44; 95% CI: 0.09–2.09).ConclusionPerioperative administration of P2Y12 inhibitors may be associated with a higher frequency of good functional outcomes in patients undergoing EVT for AIS with anterior circulation TOs. However, since several confounding factors are involved in this sub-analysis of EVT for anterior circulation TOs, further studies are warranted.
Effects of acupuncture at limb Acupoints-Guangming (GB37) on UDVA, CS, and EEG microstate in myopia
Authors: Wang Zhongqing , Yan Hao , Su Kangna , Wu Ruixin , Wang Lihan , Bi Hongsheng , Wu Jianfeng 
Published: November 2024

IntroductionAcupuncture is beneficial in improving visual function for myopi periocular acupoints Taiyang can improve contrast sensitivity (CS). In this study, we aim to further investigate the impact of acupuncture at the limbs acupoints-Guangming(GB37) acupoint on visual function, and the neural mechanism of acupuncture at the GB37 acupoint improving visual function through electroencephalography (EEG) microstate.MethodsA total of 22 myopia were recruited. Uncorrected distance visual acuity (UDVA) and CS of myopic patients were tested before and after acupuncture, and EEG data were recorded throughout the entire acupuncture procedure.ResultsOur study found that compared with pre-acupuncture, the UDVA and CS of both eyes at each spatial frequency were improved; compared with the resting state of pre-acupuncture, the duration, occurrence and contribution of microstate A were significantly increased, while those of microstate D were decreased during the post-acupuncture state. The duration of microstate A was positively correlated with the CS. There was no correlation between UDVA and EEG microstates.DiscussionAcupuncture at GB37 can improve the UDVA and CS in myopic patients, which may be related to microstate A.
Association of inflammation and nutrition status with all-cause and cardiovascular mortality in individuals with osteoarthritis: NHANES, 1999–2018
Authors: Guo Qifang , Shao Yijia , Wang Fei , Zhou Wei , Duan Xinwang 
Published: November 2024

BackgroundOsteoarthritis (OA) is the most prevalent form of arthritis worldwide. Inflammation and nutrition status play crucial roles in the development and progression of OA. The advanced lung cancer inflammation index (ALI) serves as a composite indicator for evaluating inflammation and nutritional status, while the systemic immune inflammation index (SII) is a novel marker for assessing immune-related inflammation. The study aimed to investigate the associations of the ALI and SII with all-cause and cardiovascular mortality among US adults with OA.MethodsA total of 2,602 individuals aged 20 years and above with OA were included in the study from the National Health and Nutrition Examination Survey (NHANES) spanning from 1999 to 2018. Participants were categorized into higher or lower ALI and SII groups using cut-off values determined by the maximally selected rank statistics method. The Kaplan-Meier analysis, Cox proportional hazards models, and Fine Gray competing risk regression models were employed to assess the associations between the ALI/SII and mortality in OA patients. Additionally, stratified and subgroup analyses were conducted to enhance the robustness of the findings. Furthermore, time-dependent receiver operating characteristic (ROC) analysis was used to evaluate the predictive capacity of ALI and SII for mortality.ResultsHigher SII levels were associated with a 2-fold increase in the risk of all-cause mortality (HR: 2.00, 95% CI: 1.59–2.52, p &lt; 0.001), whereas individuals with higher ALI in the OA group exhibited a significantly reduced risk of all-cause mortality (HR: 0.49, 95% CI: 0.39–0.60, p &lt; 0.001). Notably, in Model 3, individuals with higher ALI demonstrated a substantially lower risk of cardiovascular mortality (HR: 0.60, 95% CI: 0.44–0.82, p &lt; 0.001). Conversely, in fully adjusted models, those with higher SII experienced a significantly higher risk (HR: 1.83, 95% CI: 1.29–2.60, p &lt; 0.001). The RCS analysis revealed a J-shaped non-linear relationship between SII levels and all-cause mortality (p overall &lt; 0.001; p non-linear &lt; 0.001), and an L-shaped non-linear association between ALI levels and all-cause mortality (p overall &lt; 0.001; p non-linear = 0.002). The time-dependent ROC curves illustrated that ALI and SII displayed a reasonably good and consistent predictive performance for both short- and long-term mortality in OA patients.ConclusionsLower ALI and higher SII values were correlated with increased risks of all-cause and cardiovascular mortality among US adults with OA.
The characteristics of patients with multiple myeloma surviving over 10 years
Authors: Huang Beihui , Zhang Hongning , Liu Junru , Gu Jingli , Chen Meilan , Kuang Lifen , Li Xiaozhe , Li Juan 
Published: November 2024

ObjectiveTo explore the characteristics of patients with multiple myeloma (MM) who have achieved long-term survival of over 10 years in the context where novel agents and autologous stem cell transplantation (ASCT) serve as the primary therapeutic modalities.MethodsA retrospective analysis was conducted on 168 MM patients diagnosed and treated in our institution from January 2004 to January 2014. 44 patients with a survival period exceeding 10 years were categorized into the long-term survival group, while 124 patients with a survival period of less than 10 years were categorized into the non-long-term survival group.ResultsBeing younger than 57 years old (OR 3.634, 95%CI 1.302-10.143), having a neutrophil count of at least 3.66 * 109/L (OR 3.122, 95% CI 1.093-8.918), absence of high-risk genetic abnormalities (OR 7.146, 95%CI 1.066-47.904), and receiving frontline ASCT (OR 4.225, 95%CI 1.000-17.841) were positively associated with a survival period exceeding 10 years in patients with MM. Achieving sustained minimal residual disease (MRD) negativity for at least 24 months is associated with long-term survival regardless of the presence of high-risk cytogenetic abnormalities.ConclusionBeing younger, having a neutrophil count above 3.66 * 109/L, the absence of high-risk cytogenetic abnormalities, and receiving frontline ASCT are independent protective factors for transplant-eligible MM patients to survive more than 10 years. Achieving maintained MRD negativity status for over 24 months might be associated with long-term survival.
Polyvinylalcohol-carbazate mitigates acute lung injury caused by hydrochloric acid
Authors: Dong Caijuan , Liu Jielu , Quaranta Alessandro , Jing Xu , Nie Mu , Wheelock Craig E. , Murrell Benjamin , Coquet Jonathan M. , Bowden Tim Melander , Engstrand Thomas , Adner Mikael 
Published: November 2024

BackgroundAcute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are important causes of morbidity and mortality in critically ill patients. Gastric contents aspiration is one of the most common causes of ALI/ARDS. To date, there are still no specific and effective pharmacological treatments for ALI/ARDS. Polyvinylalcohol-carbazate (PVAC), a polymer that can bind endogenous aldehydes, neutralize oxidative stress and inhibit inflammatory factors, may be a potential treatment for ALI/ARDS.MethodsA hydrochloric acid (HCl) induced mouse model was employed to assess the effect of PVAC. The changes of lung mechanics, pulmonary edema, histology and immune cells, cytokines, and lipid mediators in bronchioalveolar lavage fluid (BALF) were investigated in HCl-challenged mice.ResultsIn the HCl model, PVAC administration alleviated airway hyperresponsiveness and improved pulmonary edema and damage. In addition, it decreased the recruitment of neutrophils to the lung, and inhibited the increase of IL-6, TNF-α and leukotriene B4.ConclusionThese data indicates that PVAC is a potential candidate for the treatment of ALI/ARDS induced by aspiration of gastric acid or for the control of “asthma-like” symptoms in patients with gastroesophageal reflux.
Using machine learning to identify risk factors for pancreatic cancer: a retrospective cohort study of real-world data
Authors: Su Na , Tang Rui , Zhang Yice , Ni Jiaqi , Huang Yimei , Liu Chunqi , Xiao Yuzhou , Zhu Baoting , Zhao Yinglan 
Published: November 2024

ObjectivesThis study aimed to identify the risk factors for pancreatic cancer through machine learning.MethodsWe investigated the relationships between different risk factors and pancreatic cancer using a real-world retrospective cohort study conducted at West China Hospital of Sichuan University. Multivariable logistic regression, with pancreatic cancer as the outcome, was used to identify covariates associated with pancreatic cancer. The machine learning model extreme gradient boosting (XGBoost) was adopted as the final model for its high performance. Shapley additive explanations (SHAPs) were utilized to visualize the relationships between these potential risk factors and pancreatic cancer.ResultsThe cohort included 1,982 patients. The median ages for pancreatic cancer and nonpancreatic cancer groups were 58.1 years (IQR: 51.3–64.4) and 57.5 years (IQR: 49.5–64.9), respectively. Multivariable logistic regression indicated that kirsten rats arcomaviral oncogene homolog (KRAS) gene mutation, hyperlipidaemia, pancreatitis, and pancreatic cysts are significantly correlated with an increased risk of pancreatic cancer. The five most highly ranked features in the XGBoost model were KRAS gene mutation status, age, alcohol consumption status, pancreatitis status, and hyperlipidaemia status.ConclusionMachine learning algorithms confirmed that KRAS gene mutation, hyperlipidaemia, and pancreatitis are potential risk factors for pancreatic cancer. Additionally, the coexistence of KRAS gene mutation and pancreatitis, as well as KRAS gene mutation and pancreatic cysts, is associated with an increased risk of pancreatic cancer. Our findings offered valuable implications for public health strategies targeting the prevention and early detection of pancreatic cancer.
Differential exposure to palatable food and its effects on binge-like eating behavior in adolescent rats
Authors: Chávez-Hernández María Elena , Rodríguez-Serrano Luis Miguel , Díaz-Urbina Daniel , Muñóz-Sánchez Sinuhé , Buenrostro-Jáuregui Mario Humberto , Escartín-Pérez Rodrigo Erick 
Published: November 2024

IntroductionConsumption of palatable food (PF) can lead to chronic overconsumption and obesity. Furthermore, adolescents may be vulnerable to excessively reinforcing foods, which increases the probability of developing overweight and obesity in adulthood. The role of PF availability in binge-like intake among adolescents without caloric needs remains unclear. The present study aimed to evaluate which PF access protocol is the most sensitive to induce increased caloric intake and binge-like eating during adolescence.MethodsWe used 24 male Wistar rats [30 postnatal days (PND)]; standard food and water were provided ad libitum. Rats were randomly assigned to one of three groups: (a) continuous, daily access to PF; (b) intermittent, 1-day access/1-day no-access; or (c) weekend, 3 days-access/4 days no-access. All groups had 1 h access to PF (chocolate sandwich cookies). Access protocols were maintained for 6 weeks; afterward, rats underwent a 7-day withdrawal period, and were then evaluated on a binge-eating test.ResultsChronic restricted PF access induces binge-like intake, with intermittent access resulting in the highest binge index. Additionally, caloric intake of PF increases over time during adolescence, with differential effects of intermittent and weekend access.ConclusionChronic restricted access to PF during adolescence induces binge-like intake, with differences depending on PF availability. This can lead to chronic overconsumption under non-homeostatic conditions.
Can leisure education effect on screen time and perceived leisure benefits for college students?
Authors: Özkara Abdullah Bora , Mulazimoglu Olcay , Somoglu Mustafa Baris , Kirkbir Fatih , Tokul Erdi , Aydemir Burakhan , Senturk Halil Evren , Dalbudak Ibrahim , Ozcilingir Ozgun Mirac 
Published: November 2024

BackgroundSince children and adolescents usually spend their theoretical course time at schools, they experience many negative effects of inactivity and physical inactivity. They are disadvantaged in terms of facing many health and social problems due to lack of physical activity. This sedentary life increases their exposure to screens and the time they spend sitting.Aim of the studyThe first aim of this research is to conduct an experimental study to reduce the excessive screen time of college students with an exercise intervention. The second aim of the study is to examine the perceived benefits of leisure activities of students with an exercise intervention.MethodsIn this direction, the study group of the research, which was conducted as an experimental study, consisted of 176 [74 female (42.0%), 102 male (58.0%)] students studying in the department of mathematics at college. In the study, the screen exposure time of students was measured with the “Screen time scale for youth and adolescents” along with a personal information form. In addition, the “Perceived Leisure Benefit Scale” scale was used to evaluate the participants’ awareness of the benefits obtained from leisure activities.Results and conclusionAccording to the findings of the research, it was determined that there was a positive and significant decrease in the screen time of the experimental group participants of students who participated in the research before and after the exercise intervention. In the Leisure Benefit Scale, it was observed that there were significant positive differences in favor of the experimental group.
Prevalence of homosexual and bisexual orientation in patients with borderline personality disorder and associated factors – a systematic review and meta-analysis
Authors: Shu Ying Chi Camille , Lau Ka To , Ho Cyrus Su Hui 
Published: November 2024

IntroductionThis meta-analysis aimed to quantitatively evaluate the association between homosexual and bisexual orientation and borderline personality disorder (BPD), including factors contributing to the association and clinical outcomes of homosexual and bisexual patients with BPD. MethodsWe systematically searched PUBMED, PsycINFO, Cochrane Library, MEDLINE, EMBASE and Web of Science for cross-sectional or cohort studies comparing the prevalence of homosexual and bisexual orientation amongst patients with BPD and controls. ResultsOur search identified 7 eligible studies, with a total sample case of 636 subjects with BPD and 535 subjects without BPD. Patients with BPD had a significantly higher likelihood of homosexual and bisexual orientation (Risk ratio [RR] 3.39, 95%CI 1.88-6.12) with a pooled prevalence of 28% (95% CI 0.24-0.31; I2 73%; 7 studies, 1171 participants). Subgroup analyses validated that BPD was independently associated with higher prevalence of both homosexual (RR 8.51, 95% CI 3.36-21.54) and bisexual orientation (RR 3.82, 95% CI 1.81-8.04), but no gender difference was yielded. Childhood sexual abuse (CSA) was associated with the development of homosexual and bisexual orientation in patients with BPD. DiscussionPoorer clinical outcomes, including physical and mental health, were associated with BPD status. Further studies are necessary to evaluate the feasibility and efficacy of sexual minority-specific treatment for these patients.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?RecordID=538356, identifier CRD42024538356.
The environmental health citizen interview tool: towards an inclusive qualitative environmental wellbeing approach in support of planetary health
Authors: Delbaere Ben , Pereira Barboza Evelise , Plüschke-Altof Bianka , Chebotareva Mariia , Van Rafelghem Evelien , Blockmans Lauren , Keune Hans 
Published: November 2024

BackgroundNature-based Solutions (NbS) are vital for addressing climate change and biodiversity loss, yet their benefits are often unequally distributed. This study introduces the Environmental Health Citizen Interview Tool, aiming to inclusively capture diverse perspectives on environmental wellbeing using qualitative research methods. The principles of epistemic justice and planetary health are central to its development.MethodsThe Environmental Health Citizen Interview Tool was developed as a qualitative tool, incorporating a simple visualization scoring system for responses. Six environmental health determinants were selected, with in-depth open-ended follow-up questions. Content validation involved transdisciplinary expert consultation. A guidebook for using the tool was also developed.FindingsThe tool offers a comprehensive approach to inquire environmental wellbeing, accommodating diverse perspectives through in-depth inquiries. Limitations include the need for further validation and testing.InterpretationThe Environmental Health Citizen Interview Tool provides a practical framework for inclusive assessment of environmental wellbeing, aligned with planetary health and epistemic justice principles. Its application should be complemented by quantitative environmental monitoring such as air quality and be contextualized by local researchers for reliability and relevance. Future research should focus on refining the tool and exploring its utility in diverse settings to inform equitable local policy interventions.
Physical and mental health status and influencing factors of older adults in community-dwelling in Northeast China: a cross-sectional study
Authors: Gao Mingcheng , Chen Ziyang , Li Jing , Liu Yue , Lv Run , Chen Huanhong , Zhang Lulu , He Yining , Guo Na , Zhang Yuping , Zhang Ying , Dai Xin 
Published: November 2024

BackgroundBetween 2020 and 2022, the COVID-19 pandemic spread globally, and the implementation of preventive measures led to reduced outdoor activities for older adults, resulting in a decline in social functioning. This study aims to improve community-based health interventions tailored to older adults experiencing physical and psychological declines following the COVID-19 pandemic.MethodsThis study utilized previous data mining results to estimate the demand for community health services for older adults. It involves collecting questionnaire responses to understand the basic characteristics and lifestyle behaviors of older adults. The severity of health issues among older adults was assessed using the KCL and GHQ-12 scales. Statistical analyses included descriptive statistics, chi-square tests, t-tests, ANOVA, non-parametric tests as applicable, and stratified binary logistic regression to determine the factors influencing the health status of older adults.ResultsOver 60% of the older adult population suffers from chronic diseases, and more than 70% do not participate in social activities. In the overall older adults, the detection rate for poor health is 15.60%. Chronic illness, reduced ability to perform daily activities, anxiety, poor self-rated health, sleep disturbances, and nutritional imbalance were identified as key risk factors affecting the health of older adults in the community.ConclusionOlder adults mainly engage in physical exercise, maintain a healthy lifestyle, and control their diet as self-care strategies. Early signs of frailty are characterized by declines in lower limb muscle function and memory. The most common manifestation of poor health among older adults is anxiety.
The effect of Virtual Reality Cycling with Music on simple obesity in college students: evidence from a randomized controlled trial in China
Authors: Zhao Meng , Lei Ying , Wei Ziran , You Ming 
Published: November 2024

BackgroundSimple obesity has become an increasingly prevalent health concern among college students. Existing research indicates that traditional exercise methods may not sufficiently engage this population, particularly those facing barriers to regular physical activity. Thus, this study investigated how combining VR cycling with music influenced fat reduction in this population.MethodThis study recruited 78 Chinese college students with simple obesity (BMI ≥ 28 kg/m2) and randomly assigned them to either an experimental group (VR cycling combined with music, n = 41) or a control group (traditional cycling, n = 37). Both groups engaged in 12 weeks of cycling training, three times a week, for 45 min per session. Key physiological indicators, such as weight, BMI, waist circumference, and hip circumference, were measured at baseline, mid-intervention, and post-intervention.ResultsThe VR cycling with music group exhibited significant improvements in key physiological metrics compared to the control group. Notable changes included a 4.1% reduction in weight, a 2.8% decrease in BMI, and a 2.8% reduction in waist circumference. Hip circumference also decreased by 2.5%, while the waist-to-hip ratio dropped by 0.016 units. Furthermore, the intervention led to a 7.2% increase in vital capacity, with all outcomes showing statistical significance (p&lt;0.01). The experimental group also reported higher levels of enjoyment and engagement throughout the intervention period.ConclusionParticipants in the experimental group experienced significant reductions in weight, BMI, and both waist and hip circumferences, as well as a notable improvement in vital capacity. The study highlights that combining virtual reality cycling with music resulted in more substantial weight loss and fat reduction in obese college students, compared to traditional cycling methods.