bluuebunny/crossref_metadata_2025_split huggingface dataset:
Using Of Fish Silase Different Composition Toward The Growth Of Nile Tilapia Oreochromis niloticus
Authors: Lauluw Elton R. , Lantu Sartje , Pangkey Henneke , Lumenta Cyska , Monijung Revol D. , Wantasen Adnan S. 
Published: September 2019

Silage is prepared by adding the probiotic into the material of bones and flesh of waste from the market. Silage is used as element substituted with fish meal as feed for tilapia with initial weight of 19.14 to 24.86 grams and a length of 3-5 cm. There are three types of feed using silage replacing fish meal as much as 10% (treatment A), 20% (treatment B) and 30% (treatment C) and a control used commercial feed (treatment D). The results obtained are feed in treatment D gives very significant results to the three other feed (A, B and C) in the case of weight, rate of growth and feed efficiency; but in a further test of Duncan, statistical results showed that feed C and D more efficient than feed A.Keywords: low cost artificial feed, silage, growth, tilapia ABSTRAKSilase dipersiapkan melalui penambahan probiotik ke dalam bahan tulang dan daging dari bahan-bahan yang tidak terpakai yang diambil dari pasar. Silase ini digunakan sebagai elemen yang disubsitusikan dengan tepung ikan untuk diberikan sebagai pakan pada ikan nila dengan berat awal 19,14-24,86 gr dan panjang 3-5 cm. Ada tiga jenis pakan dengan menggunakan silase menggantikan tepung ikan sebanyak 10 (perlakuan A), 20 (perlakuan B) dan 30% (perlakuan C) dan sebagai kontrol digunakan pakan komersial (perlakuan D). Hasil yang diperoleh adalah pakan uji pada perlakuan D sangat memberikan hasil berbeda yang sangat nyata dengan ketiga pakan lainnya (A, B dan C) dalam hal pertumbuhan berat, laju pertumbuhan dan efisiensi pakan; namun pada uji lanjut Duncan, hasil statistik menunjukkan bahwa pakan C dan pakan D lebih efisien dibandingkan pakan A.Kata kunci: akuakultur, pakan buatan murah, silase, pertumbuhan, ikan nila
PERBEDAAN PENGETAHUAN IBU SEBELUM DIBERI PENYULUHAN DAN SETELAH DIBERI PENYULUHAN TENTANG STIMULASI PERKEMBANGAN ANAK USIA 0-3 TAHUN (Di Posyandu 5 Kelurahan Srengat Kecamatan Srengat Kabupaten Blitar)
Authors: DARMAYANTI ROFIK , Pangestuti Fitria 
Published: September 2019

Stimulasi perkembangan yang dilakukan oleh ibu maupun keluarga sangat berpengaruh besar terhadap perkembangan seorang anak. Kurangnya pemberian stimulasi dapat menyebabkan penyimpangan tumbuh kembang bahkan gangguan yang menetap. Penelitian ini bertujuan untuk menganalisa perbedaan pengetahuan ibu sebelum diberi penyuluhan dan setelah diberi penyuluhan tentang stimulasi perkembangan anak usia 0-3 tahun.
Desain penelitian yang digunakan adalah pre-experimental design dengan menggunakan pre test-post test. Populasinya adalah semua ibu yang mempunyai anak usia 0-3 tahun yang rutin membawa anaknya ke Posyandu di Posyandu 5 Kelurahan Srengat Kecamatan Srengat Kabupaten Blitar sabanyak 23 responden. Keseluruhan populasi digunakan sebagai sampel dengan teknik total sampling. Variabel yang digunakan adalah Independent Variable yaitu penyuluhan tentang stimulasi perkembangan anak usia 0-3 tahun dan Dependent Variable yaitu pengetahuan ibu sebelum dan sesudah diberi penyuluhan tentang stimulasi perkembangan anak usia 0-3 tahun. Pengumpulan data diperoleh menggunakan kuesioner, pengolahan data melalui editing, coding, scoring dan tabulating. Untuk menguji adanya perbedaan dilakukan analisa uji Wilcoxon Match Pair Test.
Hasil penelitian menunjukkan pengetahuan ibu sebelum diberi penyuluhan tertinggi dengan kriteria pengetahuan kurang, sebanyak 13 responden (56,52%). Dan pengetahuan ibu setelah diberi penyuluhan tertinggi dengan kriteria pengetahuan baik sebanyak 15 responden (65,22%). Dari uji Wilcoxon didapatkan hasil ada perbedaan pengetahuan ibu sebelum diberi penyuluhan dan setelah diberi penyuluhan tentang stimulasi perkembangan anak usia 0-3 tahun (σ≤0,05).
Berdasarkan penelitian tersebut, dapat diketahui ada perbedaan pengetahuan ibu sebelum diberi penyuluhan dan setelah diberi penyuluhan tentang stimulasi perkembangan anak usia 0-3 tahun. Sehingga diharapkan ibu lebih aktif mencari informasi untuk menambah pengetahuan dan mendeteksi dini terjadinya keterlambatan perkembangan.
Kata kunci : , Ibu, Penyuluhan, Stimulasi, Perkembangan,
Anak
PERBEDAAN PENGETAHUAN IBU YANG MEMILIKI ANAK USIA 1-2 TAHUN SEBELUM DAN SETELAH DIBERIKAN PENYULUHAN TENTANG PENYAPIHAN ASI DI POSYANDU (Desa Bobang Kecamatan Semen Kabupaten Kediri)
Authors: DWI JAYANTI YUNDA , Sukmawati Irvin 
Published: September 2019

Penyapihan adalah suatu proses yang memungkinkan bayi dapat mengonsumsi makanan orang dewasa. Biasanya ibu-ibu khususnya di pedesaan tidak mengetahui bagaimana proses dan waktu yang tepat dalam proses penyapihan. Tujuan penelitian adalah mengetahui Perbedaan Pengetahuan Ibu Yang Memiliki Anak Usia 1-2 Tahun Sebelum dan Setelah Diberikan Penyuluhan Tentang Penyapihan ASI
Desain penelitian ini adalah penelitian one group pre post test design dengan populasi semua ibu yang memiliki anak usia 1-2 tahun. Teknik sampling yang digunakan adalah total sampling. Sampel yang digunakan 35 responden. Variabelnya penyuluhan tentang penyapihan ASI dan pengetahuan ibu tentang penyapihan ASI sebelum dan setelah diberikan penyuluhan. Pengumpulan data dengan kuesioner selanjutnya data di olah dengan editing, coding, scoring, tabulating, dan di uji dengan Willcoxon Match Pair Test.
Hasil pengetahuan ibu sebelum diberi penyuluhan adalah dari 35 responden yang diteliti didapatkan 25 responden (52,1%) sebagian besar mempunyai pengetahuan kurang. Dan setelah diberikan penyuluhan dari 35 responden yang diteliti didapatkan 25 responden (52,1) mempunyai pengetahuan cukup. Menurut hasil uji beda Willcoxon Match Pair Test didapatkan nilai Z hitung > dari Z tabel (5,16>1,96),maka H1 diterima .
Berdasarkan hasil penelitian tersebut dapat disimpulkan bahwa ada perbedaan pengetahuan ibu yang memiliki anak usia 1-2 tahun sebelum dan setelah diberikan penyuluhan tentang penyapihan ASI. Oleh karena itu, diharapkan tenaga kesehatan memberikan penyuluhan tentang penyapihan ASI dan bagi responden hendaknya mendapatkan informasi penyapihan ASI baik melalui media massa, media elektronik maupun tenaga kesehatan.
Pengetahuan, Ibu, Anak Usia 1-2 Tahun, Penyuluhan, Penyapihan ASI,
MINAT IBU NIFAS DALAM MELAKUKAN MOBILISASI DINI DI BPM NY. ANIK SULISTYAWATI (Desa Jekek Kecamatan Baron Kabupaten Nganjuk)
Authors: Dayati Rimur , Setyaningsih Yulia Ayu 
Published: September 2019

Latar belakang : Minat merupakan pengerahan perasaan dan menafsirkan untuk sesuatu hal yang timbul karena kebutuhan. Mobilisasi dini adalah kebijakan untuk selekas mungkin membimbing ibu keluar dari tempat tidurnya dan membimbingnya selekas mungkin berjalan. Namun para ibu pasca melahirkan cenderung takut untuk melakukan banyak gerakan. Tujuan dari penelitian ini adalah untuk mengetahui minat ibu nifas dalam melakukan mobilisasi dini.
Subjek dan metode : Desain pada penelitian ini adalah deskriptif. Populasi penelitian adalah 33 ibu nifas dengan menggunakan teknik total sampling dan didapatkan sampel sebesar 33 ibu nifas. Variabel yang digunakan merupakan variabel tunggal. Pengambilan data menggunakan kuesioner, penelitian dilakukan pada 16-19 mei 2016 di BPM Ny, Anik Sulistyawati Desa Jekek Kecamatan Baron Kabupaten Nganjuk.pengolahan data menggunakan Editing, Coding, Scoring, Tabulating kemudian dianalisa menggunakan prosentase.
Hasil :Hasil penelitian menunjukan bahwa dari 33 responden 24 responden (72,72%) memiliki minat Tinggi, 9 responden (27,27%) memiliki minat sedang dan 0 responden memliki minat rendah. Hampir seluruh ibu nifas dari 33 responden yang diteliti, 24 responden (72,72%) memiliki minat tinggi untuk melakukan mobilisasi dini dan 9 responden (27,27%) memiliki minat Sedang untuk melakukan mobilisasi dini.
Simpulan : Berdasarkan hasil penelitian dapat disimpulkan sebagian besar responden memiliki minat tinggi untuk melakukan mobilisasi dini. Petugas kesehatan berperan untuk mempertahankan minat ibu yang memiki minat tinggi dan meningkatkan minat ibu yang memiliki minat Sedang.
Arthroscopic Evaluation of the Subtalar Joint: A Review and Survey of Pathology
Authors: Whelan James H. , Kiser Caroline R. , Lazoritz John P. , Nelson Patrick , Sikes Jordan , Greenhagen Robert M. 
Published: September 2019

Background
A survey of pathology present in the subtalar joint by means of subtalar arthroscopy with anterolateral and middle portals has not been extensively explored in the literature. The focus of this study was to identify pathology in the subtalar joint with subtalar joint arthroscopy using this approach. We also compared these arthroscopic findings with those reported in the literature.

Methods
We performed a retrospective review of 49 consecutive patients who had undergone 53 subtalar arthroscopic procedures. Data were obtained from intraoperative arthroscopic findings that were documented in the operative note or with arthroscopic photography. Additional procedures, including ankle arthroscopy, lateral ankle stabilization, and peroneal tendon repair, were recorded. Descriptive statistics were calculated and reported.

Results
Subtalar arthroscopic examination revealed that all of the patients had intra-articular synovitis or adhesions present. Twenty-two procedures (42%) demonstrated subtalar joint instability, seven (13%) revealed chondromalacia, and one (2%) had an exostosis present. These observations are consistent with other reported findings in the literature.

Conclusions
This study found that the subtalar joint was most often affected by synovitis, adhesions, and instability in patients with symptomatic pathologies requiring subtalar arthroscopy. There was a relatively low incidence of chondromalacia or exostosis formation in the survey.
Prevalence and Susceptibility Analysis of Gram Negative Pathogens in Super Specialty Tertiary Care Centers, Pune in India from January 2018- January 2019
Authors: Satras Kishor Babaji 
Published: September 2019

Background and Objective: The encumbrance of antimicrobial resistance worldwide is substantive and likely to rise without any appropriate treatment which has enhanced the urge for the development of either new antibiotics or adjuvant therapy with antibiotics. Thus, we aimed to study a comparative antibiogram pattern of 758 clinical isolates collected from Pawana Hospital and Accord SDH, Pune (India), towards Elores (a novel antibiotic and adjutant entity of ceftriaxone, sulbactam and disodium edetate) and other antibiotics (imipenem, meropenem and piperacillin + tazobactam).
Methods: The clinical samples collected from outpatients and inpatients during a period of one year (January, 2018 to January, 2019), from Pawana Hospital and Accord SDH, Pune (India) and were further subjected to bacterial identification. Antibiotic susceptibility testing was executed in accordance with the recommendations of Clinical Laboratory Standards Institute (CLSI) guidelines.
Results: Out of 758 collected samples, urine samples contributed 69.41 and 37.63% among Enterobacteriaceae and Non-Enterobacteriaceae followed by pus (20.25 and 19.35%) and sputum (4.2 and 19.89%) while <4% and <12% Enterobacteriaceae and Non-Enterobacteriaceae isolates were collected from rest of the specimen. E. coli were found most prevalent (50.13%) along with 19.13 and 16.09% prevalence of Pseudomonas spp. and Klebsiella spp. whereas rest of the pathogens were <7% present. The antibacterial activity of Elores (87.80%) was observed superior to carbapenem drugs (meropenem; 62.67% and imipenem; 60.95%) and far better to piperacillin + tazobactam (48.42%) against 758 clinical pathogens. Antibiogram profile depicted Elores as most susceptible (95.10%) drug towards Enterobacteriaceae isolates which was approximately 31-50% more sensitive than other test drugs. Similar pattern was obtained for Non-enterobacteriaceae isolates (62.90%) where Elores contributed approximately 1-5% higher activity. However, Elores also conquered 79.51-86.59% resistance among meropenem, imipenem and piperacillin + tazobactam resistant pathogens.
Conclusion: Susceptibility profile data revealed the equivalence of Elores (Antibiotic-adjuvant entity; AAE) with carbapenem drugs (meropenem and imipenem) and superiority over piperacillin + tazobactam against clinical pathogens. Elores was also found active towards meropenem, imipenem and piperacillin + tazobactam resistant pathogens. Therefore, Elores, a resistance breaker, can be used as an efficient treatment alternate towards infections caused by resistant pathogens.
Postdoctoral nursing researcher career: A scoping review of required competences
Authors: Numminen Olivia , Virtanen Heli , Hafsteinsdóttir Thóra , Leino‐Kilpi Helena ,   Nurse Lead Consortium
Published: September 2019

AbstractAimThe aim of this review was to identify and summarize the required competences of nursing PhD students and postdoctoral researchers to pursue a successful researcher career and to compare these competences with the existing competence frameworks.DesignScoping review.MethodsPubMed, CINAHL, SocIndex, PsycInfo, Eric, EMBASE, Academic Search Premier and Scopus databases were searched from January 1990–December 2018. The guidelines of PRISMA Extension for Scoping Reviews and the scoping review framework by Arksey and O’Malley (2005, International Journal of Social Research Methodology, 8, 19) were applied.ResultsForty‐four studies were reviewed comprising 15 competence domains. Competences corroborated the competences defined in the competence frameworks. However, the qualitative and descriptive research designs rendered a modest level of evidence and generalizability.
Comprehensive Understanding of Bi‐functional Behavior of PNP‐Pincer Complexes Towards the Conversion of CO into Methanol and CO2: A DFT Approach
Authors: Ash Tamalika , Debnath Tanay , Das Abhijit K. 
Published: September 2019

AbstractThe conversion mechanisms of CO into methanol through hydrogenation and CO2 through hydrolysis catalyzed by (PNP)RuH2CO (1) pincer complex have been explored employing density functional theory (DFT). For both the reactions, we have identified two pathways. In pathway‐I, at first the CO takes part in the reaction by interacting with the Ru‐center of pincer complex and after that the H2/H2O molecule participates in the reaction, whereas in pathway‐II, the generation of hydrogenated/hydrolyzed pincer from initial pincer via the assistance of H2 or H2O molecule occurs first, followed by the reaction with CO. In case of hydrogenation, for both the pathways, CO is first converted to HCHO through hydrogenation which further undergoes hydrogenation to form methanol. In pathway‐I, the reaction of HCHO with H2 in presence of dehydrogenated pincer leads to produce methanol, whereas for pathway‐II the hydrogenated pincer formed at the beginning of this pathway carries out the aforementioned conversion. Further in presence of methanol, CO is catalytically converted to methyl formate. On the other hand, in case of hydrolysis, the conversion of CO to CO2 can be achieved in two ways, where 2nd step, i. e. formic acid to CO2 via formate ion formation follows similar mechanism for both the pathways. Overall, from our study it is revealed that the Ru‐pincer complex acts as a promising homogeneous catalyst for converting CO to various organic chemical commodities.
Health-related quality of life of carfilzomib- and daratumumab-based therapies in patients with relapsed/refractory multiple myeloma, based on German benefit assessment data
Authors: Weisel Katja , Ludwig Heinz , Rieth Achim , Lebioda Andrea , Goldschmidt Hartmut 
Published: September 2019

Abstract

Background
Carfilzomib and daratumumab are licensed in relapsed/refractory multiple myeloma (RRMM), but no head-to-head trials have been conducted.

Methods
We used data from dossiers prepared for the German Federal Joint Committee based on two phase III randomized trials of carfilzomib-based therapies (ASPIRE, ENDEAVOR) and two of daratumumab-based therapies (POLLUX, CASTOR) to conduct a descriptive assessment of health-related quality of life (HRQoL). HRQoL was assessed using the European Organisation for Research and Treatment of Cancer 30-item HRQoL Questionnaire, with hazard ratios calculated for carfilzomib- and daratumumab-based therapy versus comparators for time to HRQoL deterioration of ≥ 10 points. Analyses were also conducted on data from the EORTC 20-item myeloma-specific questionnaire, the Functional Assessment of Cancer Therapy/Gynecologic Oncology Group-Neurotoxicity scale, and the visual analog scale of the EuroQoL 5-dimension, 5-level questionnaire, where results for these instruments were available. As the designs and patient population of the four trials were similar but not identical, the analysis included only indirect, descriptive comparisons.

Results
Compared with lenalidomide/dexamethasone, median time to deterioration in global health status/QoL was longer for carfilzomib-based therapy versus control, but similar for daratumumab-based therapy and control. Compared with bortezomib/dexamethasone, time to deterioration was significantly longer for carfilzomib-based therapy versus control for global health status/QoL and numerous functional and symptom subscales. HRQoL measurement is feasible in large RRMM populations.

Conclusion
Descriptive assessment of HRQoL data suggests potential benefits for carfilzomib-based over daratumumab-based therapy.
A Suitable procedure for preparing of water Samples used in Radiocarbon Intercomparison
Authors: Takahashi H A , Minami M , Aramaki T , Handa H , Saito-Kokubu Y , Itoh S , Kumamoto Y 
Published: September 2019

ABSTRACTWe studied a suitable procedure for preparing of water samples used in radiocarbon intercomparisons involving dissolved inorganic carbon (DIC). The water samples must have inter-batch consistency and stable 14C concentrations and no sterilizing agent (e.g., HgCl2) should be added, in order to avoid the production of hazardous material. Six water samples, containing widely different amounts and types of salts, DIC, and 14C concentrations (1–100 pMC), were prepared in order to assess the procedure. Sample consistency was investigated through δ13C and chemical compositions; their low variabilities indicate that our procedure can be applied to radiocarbon intercomparison. A specific sample preparation protocol was developed for this kind of applications.
Short-term consequences of F508del-CFTR thermal instability on CFTR-dependent transepithelial currents in human airway epithelial cells
Authors: Froux Lionel , Coraux Christelle , Sage Edouard , Becq Frédéric 
Published: September 2019

AbstractLoss-of-function mutations in the Cystic Fibrosis Transmembrane conductance Regulator (CFTR) channel in human airway epithelial cells are responsible for Cystic Fibrosis. A deleterious impact of physiological temperature on CFTR plasma membrane expression, residence and channel activity is characteristic of the most common and severe CF mutation, F508del. Using primary human F508del-airway epithelial cells and CF bronchial epithelial CFBE41o- cell lines expressing F508del- or WT-CFTR, we examined the effects of temperature (29 °C-39 °C) on the amplitude and stability of short-circuit CFTR-dependent currents over time and the efficiency of pharmacological strategies to stably restore F508del-CFTR function. We show that F508del-CFTR functional instability at 37 °C is not prevented by low temperature or VX-809 correction, genistein and VX-770 potentiators, nor by the combination VX-809/VX-770. Moreover, F508del-CFTR-dependent currents 30 minutes after CFTR activation at 37 °C did not significantly differ whether a potentiator was used or not. We demonstrate that F508del-CFTR function loss is aggravated at temperatures above 37 °C while limited by a small decrease of temperature and show that the more F508del-CFTR is stimulated, the faster the current loss happens. Our study highlights the existence of a temperature-dependent process inhibiting the function of F508del-CFTR, possibly explaining the low efficacy of pharmacological drugs in clinic.
Olfactory receptor gene abundance in invasive breast carcinoma
Authors: Masjedi Shirin , Zwiebel Laurence J. , Giorgio Todd D. 
Published: September 2019

AbstractExpression of olfactory receptors (ORs) has been reported in many human tissues outside the nasal epithelium. ORs have been validated as biomarkers in prostate cancer. In breast cancer, however, the expression and role of OR genes remain understudied. We examined the significance of OR transcript abundance in a large invasive breast carcinoma population and identified two OR genes, OR2W3 and OR2B6 to be potentially correlated to breast cancer progression. 960 breast invasive tumors and 56 human breast cancer cell lines were assessed for OR gene expression and 21 OR genes were highly abundant among 198 cases. Our transcriptome analysis discovered three significantly abundant OR genes among three sub-populations of invasive breast carcinoma patients. OR2W3 was correlated with invasion genes and basal-like subtype whereas OR2B6 was correlated with proliferation genes and luminal A subtype. Analyzing the OR gene upregulation among breast cancer cell lines showed that OR2B6 and OR2W3 were abundant similar to invasive breast tumors. Our study suggests that specific OR genes may be correlated with breast cancer characteristics, making ORs potential new diagnostic, and/or treatment markers. This study suggests future directions for the exploration of a role for ORs in the mechanisms of breast cancer proliferation and progression.
Two-electron oxygen reduction on fullerene C60-carbon nanotubes covalent hybrid as a metal-free electrocatalyst
Authors: Hasanzadeh Aliyeh , Khataee Alireza , Zarei Mahmoud , Zhang Yifeng 
Published: September 2019

AbstractNanocarbon materials are considered to be active for electrochemical oxygen reduction reaction (ORR) for hydrogen peroxide (H2O2) synthesis. In the present work, a new type of fullerene 60 (C60)-carbon nanotubes (CNTs) hybrid with covalently attached C60 onto outer surface of CNTs was synthesized. The structure of C60-CNT hybrid was confirmed by physical and chemical characterizations and its conformation is proposed featuring the covalent incorporation of CNTs and C60 derivative. C60-CNT hybrid showed high efficiencies on electro-generating H2O2, owing to huge surface area and intermolecular electron-transfer in the hybrid structure. A high H2O2 production rate of 4834.57 mg L−1 h−1 (426.58 mmol L−1) was achieved at − 0.2 V vs saturated calomel electrode (SCE).