bluuebunny/crossref_metadata_2025_split huggingface dataset:
Semianalytical Estimation of Energy Deposition in the Ionosphere by Monochromatic Alfvén Waves
Authors: Verkhoglyadova Olga P. , Meng Xing , Mannucci Anthony J. , McGranaghan Ryan M. 
Published: June 2018

AbstractFor the first time we derive an analytical expression for energy deposition by propagating monochromatic Alfvén waves in the collisional ionosphere‐thermosphere (IT). Based on empirical models of IT parameters, we show an approximately 10% increase in efficiency of energy deposition at high latitudes and about 150 km altitude by Alfvén waves at 5 Hz as compared to static fields of the same magnitude. We analyze the dependence of the wave energy deposition on geomagnetic activity through a Global Ionosphere‐Thermosphere Model (GITM) simulation of IT conditions during the 13–14 October 2016 geomagnetic storm. The peak Alfvén wave contribution occurs in the E layer and lower part of the F layer. Wave‐induced heating is shown to increase in the daytime and postdusk high‐latitude F layer during the storm due to increased wave‐modified conductivity. We estimate that the Alfvén wave contribution to the IT energy budget can reach about 30% of the value of static Joule heating during a strong storm and that the actual percentage increase is dependent on latitude and altitude. This effect carries important implications for ionospheric dynamics, especially for density enhancement in the daytime cusp, heating in the vicinity of auroral arcs and ion outflow.
The Role of an Intense Front on the Connectivity of the Western Mediterranean Sea: The Cartagena‐Tenes Front
Authors: Hernández‐Carrasco I. , Orfila A. 
Published: June 2018

AbstractA combined space and time domain Self‐Organizing Maps analysis of Altimetry‐derived finite‐size Lyapunov exponents is used to extract characteristic spatial patterns of mesoscale features and to classify the western Mediterranean in regions of different variability of mixing activity. In particular, a recurrent and intense front is unveiled between Cartagena, Spain, and Tenes, Algeria, in the eastern boundary of the Alboran Sea, the here called Cartagena‐Tenes front (CTF). The temporal evolution and the frequency of occurrence of the spatial patterns and the regional variability of the mixing structures together with additional complementary Lagrangian diagnosis have been used to investigate the effect of the CFT on the regional flow connectivity. The seasonal behavior in the flux of particles through the domain associated with the degree of activation of the CTF shows that surface connectivity between the Alboran Sea and the western Mediterranean is stronger during winter and spring when the CTF is not active. Furthermore, the analysis shows that CTF becomes stronger than the Almeria‐Oran front over particular time periods, controlling the transport processes in this area. The impact of these fronts on transported substances has been analyzed based on Chlorophyll‐a satellite distribution, showing how the Lagrangian Coherent Structures, separate regions of different connectivity properties, affecting on the dynamical and biological behavior.
Relative Sea Level, Tides, and Extreme Water Levels in Boston Harbor From 1825 to 2018
Authors: Talke S. A. , Kemp A. C. , Woodruff J. 
Published: June 2018

AbstractUsing newly‐discovered archival measurements, we construct an instrumental record of water levels and storm tides in Boston (MA) since 1825. After ascertaining the 19th century datum and correcting for a 0–0.03 m bias in the modern tide‐gauge record, we show that local, decadally‐averaged relative sea level (RSL) rose by 0.28 ± 0.05 m since 1826, with an acceleration of 0.023 ± 0.009 mm/yr2. Tide range decreased by 5.5% between 1830 and 1910, due in large part to dredging and filling of Boston Harbor, and trended slightly upward thereafter. An evaluation of storm events since 1825 suggests that trends in flood risk are driven by RSL rise, with a small contribution by tidal trends. Sea‐level rise also interacts with the 18.6 year nodal cycle in tide amplitudes to produce decadal fluctuations in hazard. Conditional sampling of the 1825–2018 record shows that storm tides with a 0.01–0.5 annual probability (100 and 2 year events) are 0.1–0.2 m larger during periods with above‐average tidal amplitudes. Similarly, the once‐in‐25 year event during elevated tidal forcing becomes a once‐in‐100 year event during periods of reduced tides. A plurality of historic flood events—including floods in 1851, 1978, and 2018—occurred near the peak of the tidal nodal cycle. Projections to the year 2100 suggest that decadal fluctuations in tide characteristics will interact with relative sea‐level rise to produce a fluctuating hazard over time, with periods of relative stationarity (e.g., the 2020s) bracketed by relatively abrupt increases in flood hazard (the early 2030s).
Orientation and Stability of Asymmetric Magnetic Reconnection X Line
Authors: Liu Yi‐Hsin , Hesse M. , Li T. C. , Kuznetsova M. , Le A. 
Published: June 2018

AbstractThe orientation and stability of the reconnection x line in asymmetric geometry is studied using three‐dimensional (3‐D) particle‐in‐cell simulations. We initiate reconnection at the center of a large simulation domain to minimize the boundary effect. The resulting x line has sufficient freedom to develop along an optimal orientation, and it remains laminar. Companion 2‐D simulations indicate that this x line orientation maximizes the reconnection rate. The divergence of the nongyrotropic pressure tensor breaks the frozen‐in condition, consistent with its 2‐D counterpart. We then design 3‐D simulations with one dimension being short to fix the x line orientation but long enough to allow the growth of the fastest growing oblique tearing modes. This numerical experiment suggests that reconnection tends to radiate secondary oblique tearing modes if it is externally (globally) forced to proceed along an orientation not favored by the local physics. The development of oblique structure easily leads to turbulence inside small periodic systems.
Comprehensive Analysis of the Counter Equatorial Electrojet: Average Properties as Deduced From CHAMP Observations
Authors: Zhou Yun‐Liang , Lühr Hermann , Xu Hong‐wen , Alken Patrick 
Published: June 2018

AbstractTen years of geomagnetic field observations by the CHAMP satellite are used for a systematic investigation of the counter equatorial electrojet (CEJ). For the first time a comprehensive characterization of CEJ is presented. CEJs occur preferably during early morning, and their occurrence rate is down to 4% at noon. The CEJ occurrence rate shows a clear annual variation with a peak around July–August and a secondary peak in January. The late summer peak is related to the effect of meteor dust ablation. The CEJ amplitude is closely controlled by magnetic activity, showing a good correlation with the aP index. Nonmigrating solar tides are the main reason for longitudinal patterns of occurrence rate. The most prominent wavenumber 1 longitudinal structures during all seasons can be attributed to the tidal components SW3 and SPW1. The wavenumber 4 becomes largest during late summer‐autumn season, which is related to the DE3 component. Also, the influence of lunar tides is evident in the CEJ occurrence rate. Strongest modulation of the CEJ by the semidiurnal lunar M2 tide is observed around January, which is responsible for the secondary CEJ occurrence peak in January. Both the solar and lunar tidal waves appear out of phase between CEJ and equatorial electrojet, implying that the same tidal mechanisms influence both current systems. Changes of solar wind conditions can also influence the CEJ. Immediately after a sudden increase of solar wind input CEJs are depressed, but about 3 hr after that event CEJs are strongly enhanced because of the disturbance wind dynamo.
YAP promotes osteogenesis and suppresses adipogenic differentiation by regulating β-catenin signaling
Authors: Pan Jin-Xiu , Xiong Lei , Zhao Kai , Zeng Peng , Wang Bo , Tang Fu-Lei , Sun Dong , Guo Hao-han , Yang Xiao , Cui Shun , Xia Wen-Fang , Mei Lin , Xiong Wen-Cheng 
Published: June 2018

AbstractYAP (yes-associated protein) is a transcriptional factor that is negatively regulated by Hippo pathway, a conserved pathway for the development and size control of multiple organs. The exact function of YAP in bone homeostasis remains controversial. Here we provide evidence for YAP’s function in promoting osteogenesis, suppressing adipogenesis, and thus maintaining bone homeostasis. YAP is selectively expressed in osteoblast (OB)-lineage cells. Conditionally knocking out Yap in the OB lineage in mice reduces cell proliferation and OB differentiation and increases adipocyte formation, resulting in a trabecular bone loss. Mechanistically, YAP interacts with β-catenin and is necessary for maintenance of nuclear β-catenin level and Wnt/β-catenin signaling. Expression of β-catenin in YAP-deficient BMSCs (bone marrow stromal cells) diminishes the osteogenesis deficit. These results thus identify YAP-β-catenin as an important pathway for osteogenesis during adult bone remodeling and uncover a mechanism underlying YAP regulation of bone homeostasis.
Visualizing hydrogen-induced reshaping and edge activation in MoS2 and Co-promoted MoS2 catalyst clusters
Authors: Grønborg Signe S. , Salazar Norberto , Bruix Albert , Rodríguez-Fernández Jonathan , Thomsen Sean D. , Hammer Bjørk , Lauritsen Jeppe V. 
Published: June 2018

AbstractHydrodesulfurization catalysis ensures upgrading and purification of fossil fuels to comply with increasingly strict regulations on S emissions. The future shift toward more diverse and lower-quality crude oil supplies, high in S content, requires attention to improvements of the complex sulfided CoMo catalyst based on a fundamental understanding of its working principles. In this study, we use scanning tunneling microscopy to directly visualize and quantify how reducing conditions transforms both cluster shapes and edge terminations in MoS2and promoted CoMoS-type hydrodesulfurization catalysts. The reduced catalyst clusters are shown to be terminated with a fractional coverage of sulfur, representative of the catalyst in its active state. By adsorption of a proton-accepting molecular marker, we can furthermore directly evidence the presence of catalytically relevant S–H groups on the Co-promoted edge. The experimentally observed cluster structure is predicted by theory to be identical to the structure present under catalytic working conditions.
Genetic fine-mapping of the Iowan SNCA gene triplication in a patient with Parkinson’s disease
Authors: Zafar Faria , Valappil Ruksana Azhu , Kim Sam , Johansen Krisztina K. , Chang Anne Lynn S. , Tetrud James W. , Eis Peggy S. , Hatchwell Eli , Langston J. William , Dickson Dennis W. , Schüle Birgitt 
Published: June 2018

AbstractThe “Iowa kindred,” a large Iowan family with autosomal-dominant Parkinson’s disease, has been followed clinically since the 1920s at the Mayo Clinic. In 2003, the genetic cause was determined to be a 1.7 Mb triplication of the alpha-synuclein genomic locus. Affected individuals present with an early-onset, severe parkinsonism-dementia syndrome. Here, we present a descendant of the Iowa kindred with novel, disease-associated non-motor findings of reduced heart rate variability, complete anosmia, and a rare skin condition called colloid milium. At autopsy, key neuropathological findings were compatible with diffuse Lewy body disease. Using high-resolution comparative genomic hybridization (CGH) array analysis to fine-map the genomic breakpoints, we observed two independent recombination events of the SNCA locus that resulted in a genomic triplication of twelve genes, including SNCA, and the disruption of two genes, HERC6 and CCSER1, at the genomic breakpoints. In conclusion, we provide further evidence that the mere two-fold overexpression of alpha-synuclein leads to a fulminant alpha-synucleinopathy with rapid progression and severe clinical and neuropathological features.
Unveiling structural, chemical and magnetic interfacial peculiarities in ε-Fe2O3/GaN (0001) epitaxial films
Authors: Ukleev Victor , Suturin Sergey , Nakajima Taro , Arima Taka-hisa , Saerbeck Thomas , Hanashima Takayasu , Sitnikova Alla , Kirilenko Demid , Yakovlev Nikolai , Sokolov Nikolai 
Published: June 2018

AbstractThe metastable ε-Fe2O3 is known to be the most intriguing ferrimagnetic and multiferroic iron oxide phase exhibiting a bunch of exciting physical properties both below and above room temperature. The present paper unveils the structural and magnetic peculiarities of a few nm thick interface layer discovered in these films by a number of techniques. The polarized neutron reflectometry data suggests that the interface layer resembles GaFeO3 in composition and density and is magnetically softer than the rest of the ε-Fe2O3 film. While the in-depth density variation is in agreement with the transmission electron microscopy measurements, the layer-resolved magnetization profiles are qualitatively consistent with the unusual wasp-waist magnetization curves observed by superconducting quantum interference device magnetometry. Interestingly a noticeable Ga diffusion into the ε-Fe2O3 films has been detected by secondary ion mass spectroscopy providing a clue to the mechanisms guiding the nucleation of exotic metastable epsilon ferrite phase on GaN at high growth temperature and influencing the interfacial properties of the studied films.
Radiologists can detect the ‘gist’ of breast cancer before any overt signs of cancer appear
Authors: Brennan Patrick C. , Gandomkar Ziba , Ekpo Ernest U. , Tapia Kriscia , Trieu Phuong D. , Lewis Sarah J. , Wolfe Jeremy M. , Evans Karla K. 
Published: June 2018

AbstractRadiologists can detect abnormality in mammograms at above-chance levels after a momentary glimpse of an image. The study investigated this instantaneous perception of an abnormality, known as a “gist” response, when 23 radiologists viewed prior mammograms of women that were reported as normal, but later diagnosed with breast cancer at subsequent screening. Five categories of cases were included: current cancer-containing mammograms, current mammograms of the normal breast contralateral to the cancer, prior mammograms of normal cases, prior mammograms with visible cancer signs in a breast from women who were initially reported as normal, but later diagnosed with breast cancer at subsequent screening in the same breast, and prior mammograms without any visible cancer signs from women labelled as initially normal but subsequently diagnosed with cancer. Our findings suggest that readers can distinguish patients who were diagnosed with cancer, from individuals without breast cancer (normal category), at above-chance levels based on a half-second glimpse of the mammogram even before any lesion becomes visible on the mammogram. Although 20 of the 23 radiologists demonstrated this ability, radiologists’ abilities for perceiving the gist of the abnormal varied between the readers and appeared to be linked to expertise. These results could have implications for identifying women of higher than average risk of a future malignancy event, thus impacting upon tailored screening strategies.
Molecular profiling and sequential somatic mutation shift in hypermutator tumours harbouring POLE mutations
Authors: Hatakeyama Keiichi , Ohshima Keiichi , Nagashima Takeshi , Ohnami Shumpei , Ohnami Sumiko , Serizawa Masakuni , Shimoda Yuji , Maruyama Koji , Akiyama Yasuto , Urakami Kenichi , Kusuhara Masatoshi , Mochizuki Tohru , Yamaguchi Ken 
Published: June 2018

AbstractDefective DNA polymerase ε (POLE) proofreading leads to extensive somatic mutations that exhibit biased mutational properties; however, the characteristics of POLE-mutated tumours remain unclear. In the present study, we describe a molecular profile using whole exome sequencing based on the transition of somatic mutations in 10 POLE-mutated solid tumours that were obtained from 2,042 Japanese patients. The bias of accumulated variations in these mutants was quantified to follow a pattern of somatic mutations, thereby classifying the sequential mutation shift into three periods. During the period prior to occurrence of the aberrant POLE, bare accumulation of mutations in cancer-related genes was observed, whereas PTEN was highly mutated in conjunction with or subsequent to the event, suggesting that POLE and PTEN mutations were responsible for the development of POLE-mutated tumours. Furthermore, homologous recombination was restored following the occurrence of PTEN mutations. Our strategy for estimation of the footprint of somatic mutations may provide new insight towards the understanding of mutation-driven tumourigenesis.
Enhancing coherence via tuning coupling range in nonlocally coupled Stuart–Landau oscillators
Authors: Zhao Nannan , Sun Zhongkui , Xu Wei 
Published: June 2018

AbstractNonlocal coupling, as an important connection topology among nonlinear oscillators, has attracted increasing attention recently with the research boom of chimera states. So far, most previous investigations have focused on nonlocally coupled systems interacted via similar variables. In this work, we report the evolutions of dynamical behaviors in the nonlocally coupled Stuart–Landau oscillators by applying conjugate variables feedback. Through rigorous analysis, we find that the oscillation death (OD) can convert into the amplitude death (AD) via the cluster state with the increasing of coupling range, making the AD regions to be expanded infinitely along two directions of both the natural frequency and the coupling strength. Moreover, the limit cycle oscillation (OS) region and the mixed region of OD and OS will turn to anti-synchronization state through amplitude-mediated chimera. Therefore, the procedure from local coupling to nonlocal one implies indeed the continuous enhancement of coherence among neighboring oscillators in coupled systems.
Immunoprofiles of human Sertoli cells infected with Zika virus reveals unique insights into host-pathogen crosstalk
Authors: Strange Daniel P. , Green Richard , Siemann David N. , Gale Michael , Verma Saguna 
Published: June 2018

AbstractConfirmed reports of Zika virus (ZIKV) in seminal fluid months after clearance of viremia suggests that ZIKV can establish persistent infection in the seminiferous tubules, an immune privileged site of the testis. The seminiferous tubule epithelium is mainly composed of Sertoli cells that function to nourish and protect developing germ cells. We recently demonstrated that primary human Sertoli cells (hSeC) were highly susceptible to ZIKV as compared to dengue virus without causing cell death and thus may act as a reservoir for ZIKV in the testes. However, the cellular and immune responses of hSeC to infection with ZIKV or any other virus are not yet characterized. Using genome-wide RNA-seq to compare immunoprofiles of hSeC, we show that the most prominent response to ZIKV at early stage of infection was suppression of cell growth and proliferation functional pathways. Peak virus replication was associated with induction of multiple antiviral defense pathways. Unique ZIKV-associated signatures included dysregulation of germ cell-Sertoli cell junction signaling. This study demonstrates that hSeC are capable of signaling through canonical pro-inflammatory pathways and provides insights into unique cell-type-specific response induced by ZIKV in association with viral persistence in the testes.
Recurrent development of song idiosyncrasy without auditory inputs in the canary, an open-ended vocal learner
Authors: Mori Chihiro , Liu Wan-chun , Wada Kazuhiro 
Published: June 2018

AbstractComplex learned behaviors, like bird song and human speech, develop under the influence of both genetic and environmental factors. Accordingly, learned behaviors comprise species specificity and individual variability. Auditory information plays a critical role in vocal learning by songbirds, both to memorize tutor songs and to monitor own vocalizations. Nevertheless, audition-deprived songbirds develop structured, species-specific song patterns. It remains to be elucidated how the auditory input contributes to the development of individual variability of song characteristics. Here we show that an open-ended vocal learner, the canary, annually recapitulates individually unique songs without audition. Although the total number of syllable types was reduced by auditory deprivation, other vocal phenotypes examined in the syllable, phrase, and syntax of songs were conserved between the 1st and 2nd years, both in deafened and intact birds. In deafened canaries, approximately 60% of the syllables were yearly reproduced with consistent acoustic features, whereas the remaining syllables were replaced with new ones in an annual cycle of song development. These results indicate that the open-ended vocal learning of canaries involves an audition-independent mechanism for the development of recurrent song idiosyncrasy.
Effects of repeated transcranial direct current stimulation on smoking, craving and brain reactivity to smoking cues
Authors: Mondino Marine , Luck David , Grot Stéphanie , Januel Dominique , Suaud-Chagny Marie-Françoise , Poulet Emmanuel , Brunelin Jérôme 
Published: June 2018

AbstractRecent studies have shown that transcranial direct current stimulation (tDCS) may reduce craving and smoking. However, little is known regarding brain correlates of these behavioral changes. We aimed to evaluate whether 10 sessions of tDCS modulate cigarette consumption, craving and brain reactivity to smoking cues in subjects with tobacco use disorder (TUD). In a double blind parallel-arms study, 29 subjects with TUD who wished to quit smoking were randomly assigned to receive 10 sessions of either active or sham tDCS applied with the anode over the right dorsolateral prefrontal cortex (DLPFC) and a large cathode over the left occipital region. As compared to sham, active tDCS significantly reduced smoking craving and increased brain reactivity to smoking-cues within the right posterior cingulate, as measured with a functional magnetic resonance imaging event-related paradigm. However, we failed to find a significant difference between active and sham groups regarding the self-reported number of cigarettes smoked and the exhaled carbon monoxide during one month. These findings suggested that 10 sessions of tDCS over the right DLPFC may reduce craving by modulating activity within the resisting-to-smoke network but might not be significantly more effective than sham to decrease cigarette consumption.