bluuebunny/crossref_metadata_2025_split huggingface dataset:
Myeloproliferative neoplasms in the young: Mayo Clinic experience with 361 patients age 40 years or younger
Authors: Szuber Natasha , Vallapureddy Rangit R. , Penna Domenico , Lasho Terra L. , Finke Christy , Hanson Curtis A. , Ketterling Rhett P. , Pardanani Animesh , Gangat Naseema , Tefferi Ayalew 
Published: August 2018

AbstractBetween 1967 and 2017, 361 patients with myeloproliferative neoplasms (MPN), age ≤ 40 years, were seen at our institution, constituting 12% of all MPN patients (n = 3023) seen during the same time period; disease‐specific incidences were 12% in polycythemia vera (PV; n = 79), 20% in essential thrombocythemia (ET; n = 219) and 5% in primary myelofibrosis (PMF; n = 63). Compared to their older counterparts, younger patients were more likely to present with low risk disease (P < .001) and display female preponderance in ET (P = .04), lower incidence of arterial events overall (P < .001), and higher incidence of venous thrombosis in PV (P = .01). Younger patients were also more likely to express CALR mutations, in ET and PMF, normal karyotype, in PV and PMF, and lower incidence of high molecular risk mutations in PMF (P significant in all instances). Over median follow‐up of 11.3, 13, and 7.1 years for PV, ET, and PMF, leukemic transformations were respectively documented in 4%, 2%, and 10% (P values 0.1‐0.9) while incidences of fibrotic progression in PV (22%) and ET (16%) were expectedly higher in young patients, because of their longer survival (P < .001). Median survival in young patients was 37 years for PV, 35 for ET and 20 for PMF; the corresponding values were 22, 22, and 8 years for ages 41‐60 years and 10, 11, and 3 years for ages >60 years (P < .001). Young MPN patients comprise a unique disease subset defined by an attenuated‐risk cytogenetic and mutational backdrop and conspicuously longer survival compared to their older counterparts, which requires assertion during patient counseling.
Functionalization of multiwalled carbon nanotubes by amidation and Michael addition reactions and the effect of the functional chains on the properties of waterborne polyurethane composites
Authors: Wang Shaohui , Li Shasha , Hou Caiying , Ma Guozhang , Wang Hezhi , Wu Jianbin , Hao Xiaogang , Zhang Hui 
Published: August 2018

ABSTRACTA new class of hydrophilic multiwalled carbon nanotubes (MWCNTs) was prepared by amidation of carboxylated MWCNTs and then undergoing the Michael addition reactions with hydroxyethyl acrylate (HEA), acryloyl morpholine (ACMO), and acrylamide (AM), respectively. The functionalized MWCNTs were dispersible well in water showing zeta potential value of higher than −33.8 mV. After used as reinforcing filler to fabricate the waterborne polyurethane (WPU) composites, the functionalized MWCNTs showed more homogenous dispersion and stronger interfacial adhesion in/with WPU matrix in comparison with pristine MWCNTs, leading to an effective improvement in the mechanical properties, hydrophilicity and electrical conductivity of the MWCNTs/WPU composites. As fabrication of 1.5 wt % MWCNTs composite, the tensile stress was greatly enhanced by about 20.3, 22.5, and 30.1% from 13.3 MPa of the pristine MWCNTs composites to 16.0, 16.3, and 17.3 MPa for the MWCNTs‐HEA, ‐ACMO, and ‐AM composites, respectively. Varying hydrophilic moieties offered different mechanical properties and electrical conductivities to the MWCNTs/WPU composites, which is suggested to be caused by the improved compatibility and hydrogen bonds between the functionalized MWCNTs and WPU macromolecules. © 2018 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2018, 135, 46757.
Antimicrobial activity of nisin‐coated polylactic acid film facilitated by cold plasma treatment
Authors: Hu S. , Li P. , Wei Z. , Wang J. , Wang H. , Wang Z. 
Published: August 2018

ABSTRACTIn this investigation, the surface functionalization of polylactic acid (PLA) film has been carried out by cold plasma treatment (CPT) to facilitate the coating of nisin on its surface. The physical and chemical properties of PLA films, such as surface morphology, water contact angle (WCA), chemical structure, and dynamic mechanical thermal properties, after CPT were systematically investigated. The obtained results demonstrated that the oxygen/carbon (O/C) ratio of PLA films decreased from 0.46 to 0.40 with an increase in the time of CPT. As the time of CPT increased, the roughness at first increased to 6.24 nm for PLA30, but then decreased to 2.26 nm for PLA60, whereas WCA at first decreased to 51.06° but then increased to 75°. Attenuated total reflectance Fourier transform infrared spectroscopy confirmed the successful coating of nisin onto PLA films with CPT. As compared with the PLA film, PN60 decreased the total viable count of Listeria monocytogenes to 2.25 log10[CFU/mL]. The different antimicrobial abilities against L. monocytogenes indicated that CPT could affect the adsorption capacity of PLA surface. © 2018 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2018, 135, 46844.
Aluminosilicate nanofibers with ordered pores derived from block copolymer electrospun nanofibers
Authors: Dorneles M. F. , Oréfice R. L. 
Published: August 2018

ABSTRACTThe self‐assembling phenomenon of block copolymers (BCPs) can be used to spatially organize inorganic entities to create chemical patterns that can be converted into high‐surface area materials. In this study, electrospun nanofibers with ordered phases were designed and prepared using BCPs as the templates to control the distribution of inorganic nanoparticles (NPs). To this end, blends of Pluronic F127 BCP and poly(caprolactone) (in a 2:1 ratio) containing different amounts of aluminosilicate NPs (obtained through a sol–gel process) were electrospun. The nanofibers thus produced were pyrolyzed at 600 °C. The results indicated that the inorganic NPs were selectively located within the more hydrophilic domains of the BCP. The small angle X‐ray scattering results showed that the amount of inorganic NPs incorporated in the nanofibers affected the morphology of the BCPs, yielding structures ranging from lamellae to hexagonal array of cylinders. After pyrolysis, aluminosilicate‐rich fibers with a hexagonal array of cylindrical pores were obtained. © 2018 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2018, 135, 46868.
Design and synthesis of antibacterial waterborne fluorinated polyurethane
Authors: Zhao B. , Jia R. , Zhang Y. , Liu D. , Zheng X. 
Published: August 2018

ABSTRACTAntibacterial waterborne polyurethanes (WPUs) have attracted increasing attention in a wide range of industrial applications because of their versatile properties as well as ecofriendly nature. Although extensive research has been carried out on antibacterial WBPU synthesis, the roles of some of the key synthesis components remain unclear. In this study, the novel chain extender DMG (dimethylol propionamide containing guanidine group) was designed and synthesized, which has not been reported before. DMG and the waterborne fluorinated polyurethanes containing DMG show high bactericidal (> 99.99%) efficacy against a broad spectrum of gram‐positive and gram‐negative bacteria. Furthermore, when the amount of DMG reached 5%, the average particle size of waterborne fluorinated polyurethane dispersions was 56.24 nm. And waterborne fluorinated polyurethanes showed good thermal (> 460 °C) properties and high crystallization with the increase of chain extender DMG. The successful synthesis of these fascinating antibacterial waterborne materials may provide new insights into the development of protection materials in a sustainable form, which could be applied as coatings in various fields to prevent microbial contamination. © 2018 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 46923.
The design and properties study of a novel styryl‐pyridinium‐based water‐soluble fluorescent copolymer as tracing agent
Authors: Yan Liwei , Su Chunjiao , Shen Linghong , Lv Mingqian , Liu Cheng , Liu Xuan , Liu Guangsheng , Li Jialing , Ye Zhongbin 
Published: August 2018

ABSTRACTA water‐soluble fluorescent copolymer poly(acrylamide‐acrylic acid‐styrene pyridinium) (PAAS) for detecting polymer concentration in real time was synthesized via micellar free‐radical polymerization by acrylamide, acrylic acid, and styryl‐pyridinium salt derivative (SP‐4). The special Donor‐π‐Acceptor unit and ionic structure of SP‐4 endued the copolymer with excellent fluorescent properties and remarkable water solubility. The fluorescent copolymer was fully characterized by Fourier transform infrared, 1H nuclear magnetic resonance, thermogravimetry, Ubbelohde viscosity, ultraviolet–visible spectroscopy, and fluorescence measurements. Furthermore, the fluorescence intensity and the concentration of PAAS were verified to have ideal linear relationship with a correlation coefficient up to 0.9993, indicating that the copolymer's concentration can be easily measured by detecting its fluorescence intensity. Most importantly, the introduction of water‐soluble fluorescent monomer SP‐4 endowed the PAAS with good fluorescent stability in a wide range of temperature, pH, and brine concentrations. This study demonstrated that the fluorescent copolymer PAAS exhibits great potential application in detecting polymer concentration in various environments. © 2018 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 47062.
The Risk of Gout Among Patients With Sleep Apnea: A Matched Cohort Study
Authors: Blagojevic‐Bucknall Milica , Mallen Christian , Muller Sara , Hayward Richard , West Sophie , Choi Hyon , Roddy Edward 
Published: August 2018

ObjectiveObstructive sleep apnea (OSA) is associated with a range of serious comorbidities. This study was undertaken to investigate whether people with OSA are more likely to develop gout, in the short and long term, compared to those without OSA.MethodsA matched retrospective cohort study was undertaken using the UK Clinical Practice Research Datalink. Individuals age ≥18 years who received a diagnosis of OSA between 1990 and 2010 were identified and matched on age, sex, and practice with up to 4 individuals without OSA; follow‐up was until the end of 2015. Hazard ratios (HRs) were estimated using Cox regression adjusted for general health, lifestyle, and comorbidity characteristics. The risk of developing gout was assessed at different time points, and the body mass index (BMI) category–specific results were presented.ResultsThe study sample included 15,879 patients with OSA and 63,296 without. The median follow‐up was 5.8 years. We found that 4.9% of patients with OSA and 2.6% of patients without the disorder developed gout. The incidence rate per 1,000 person‐years was 7.83 (95% confidence interval [95% CI] 7.29–8.40) and 4.03 (95% CI 3.84–4.23) among those with and without OSA, respectively. The adjusted HR was 1.42 (95% CI 1.29–1.56). The risk of developing gout among OSA patients compared to those without was highest 1–2 years after the index date (HR 1.64 [95% CI 1.30–2.06]). This finding persisted among those who were overweight and obese. For those with normal BMI, the highest significant HR (2.02 [95% CI 1.13–3.62]) was observed at 2–5 years after the index date.ConclusionIn this study, patients with OSA continued to be at higher risk of developing gout beyond the first year following the diagnosis. Our results further indicate that peak incidences of gout vary according to BMI.
Finite‐Time Average Consensus Based Approach for Distributed Convex Optimization
Authors: Ma Wenlong , Fu Minyue , Cui Peng , Zhang Huanshui , Li Zhipeng 
Published: August 2018

AbstractIn this paper, we consider a distributed convex optimization problem where the objective function is an average combination of individual objective function in multi‐agent systems. We propose a novel Newton Consensus method as a distributed algorithm to address the problem. This method utilises the efficient finite‐time average consensus method as an information fusion tool to construct the exact Newtonian global gradient direction. Under suitable assumptions, this strategy can be regarded as a distributed implementation of the classical standard Newton method and eventually has a quadratic convergence rate. The numerical simulation and comparison experiment show the superiority of the algorithm in convergence speed and performance.
A Globally Convergent Adaptive Indirect Field‐Oriented Torque Controller for Induction Motors
Authors: Ortega Romeo , Pyrkin Anton , Bobtsov Alexey , Efimov Denis , Aranovskiy Stanislav 
Published: August 2018

AbstractOne of the most challenging problems in AC drives applications is the design of a simple plug‐in adaptation scheme to estimate the unknown rotor resistance and load torque for the industry‐standard indirect field oriented control. In this paper we give the first globally convergent solution to this problem for torque control of current‐fed induction motors that does not rely on any excitation assumption. Some results on speed regulation are also presented.
Closed‐form approximations for spread options in Lévy markets
Authors: Van Belle Jente , Vanduffel Steven , Yao Jing 
Published: August 2018

AbstractWe provide new closed‐form approximations for the pricing of spread options in three specific instances of exponential Lévy markets, ie, when log‐returns are modeled as Brownian motions (Black‐Scholes model), variance gamma processes (VG model), or normal inverse Gaussian processes (NIG model). For the specific case of exchange options (spread options with zero strike), we generalize the well‐known Margrabe formula (1978) that is valid in a Black‐Scholes model to the VG model under a homogeneity assumption.
Using steam explosion or AFEX™ to produce animal feeds and biofuel feedstocks in a biorefinery based on sugarcane residues
Authors: Mokomele Thapelo , da Costa Sousa Leonardo , Bals Bryan , Balan Venkatesh , Goosen Neill , Dale Bruce E. , Görgens Johann F. 
Published: August 2018

AbstractSustainable integration of biofuel (primarily bioethanol) and highly digestible livestock feed in production systems is a potential way to increase the economic returns to agriculture and simultaneously promote energy security, particularly in developing countries. In this work we evaluated the efficacy of steam explosion (StEx) and ammonia fiber expansion (AFEX™) as potential processes for improving thein vitrorumen digestibility, metabolizable energy, and ethanol yields from sugarcane crop residues (bagasse and cane leaf matter, CLM). Ammonia fiber expansion pretreatment enhanced thein vitrotrue digestibility and metabolizable energy content of sugarcane crop residues by 69% and 26%, respectively compared to untreated controls. On the other hand, StEx increased the true digestibility and metabolizable energy content of the sugarcane residues by 54% and 7%, respectively. Ammonia fiber expansion also increased the total nitrogen content of both sugarcane bagasse and CLM to more than 20.2 g kg−1dry forage, a more than 230% improvement relative to untreated controls. High solid‐loading enzymatic hydrolysis and fermentation of StEx‐ and AFEX™‐pretreated sugarcane crop residues generated yields of up to 3368 and 4360 L of ethanol per hectare of sugarcane cultivated, respectively, at a biomass‐degrading enzyme dosage of 20 mg protein per gram glucan. This research strongly suggests that the use of suitably pretreated sugarcane crop residues in integrated sugarcane biofuel‐livestock production systems can increase the total per hectare agricultural output without increasing the area of sugarcane cultivated. In effect, this integrated approach promotes more sustainable biofuel production and increased food production while avoiding the potential for indirect land use change. © 2018 Society of Chemical Industry and John Wiley & Sons, Ltd
What have we learnt about board gender diversity as a business strategy? The appointment of board subcommittees
Authors: Pucheta‐Martínez María Consuelo , Bel‐Oms Inmaculada 
Published: August 2018

AbstractThis paper explores whether a board's gender diversity influences the voluntary formation of its board subcommittees. Female board directorship may become a business strategy for firms if it affects the appointment of board subcommittees. We hypothesize that the voluntary creation of board subcommittees is affected by the presence of female directors on boards; the presence of independent, executive, and institutional female directors; and the proportion of shares held by female directors on boards. Board gender diversity has been measured as a proportion and with Blau's index. The results show that independent female directors are positively associated with the likelihood of voluntarily setting up all or some of the committees and a supervision and control committee. The presence of executive female directors negatively influences the probability of forming all or some of the committees, an executive committee and a supervision and control committee. The percentage of shares held by female directors has a positive effect on the voluntary creation of an executive committee. The findings also report that women directors and institutional female directors do not contribute to the voluntary creation of board subcommittees. Our evidence shows that female board directorship impacts the demand of internal control mechanisms such as board subcommittees, suggesting that firms should take it into account as a business strategy. The main implications derived from this research are relevant for Spanish policymakers and researchers because board gender diversity may play a significant role in the decision‐making processes of firms and may influence firms' outcomes.
A web‐based virtual laboratory for SHRIMP
Authors: Liu Yi‐Han , He Yu‐Tong , Tian Di , Fan Run‐Long , Yao Li 
Published: August 2018

AbstractThis paper introduces a novel web‐based virtual laboratory to assist teaching of Sensitive High Resolution Ion Micro‐probe (SHRIMP) implementation, called SHRIMP VL. This virtual laboratory is especially designed to aid learning of the instrument operation procedure. SHRIMP VL was developed based on hypertext preprocessor (PHP) technology and the Browser/Server application model, combined with the Yii framework and database technology. The virtual lab includes a virtual experiment platform to simulate the experiment procedure of the actual instrument and show experiment results. It also provides an immersive and visible virtual environment with navigational hints to guide user learning of the experiment operation, as well as theory presentations. To evaluate this virtual laboratory, two questionnaires were provided to students, who reported that SHRIMP VL is effective in helping them understand and master the instrument and experimental procedures, thereby improving their learning efficiency and laying foundations for personal operation of on‐site instruments.
SNP interactions of PGC with its neighbor lncRNAs enhance the susceptibility to gastric cancer/atrophic gastritis and influence the expression of involved molecules
Authors: Lv Zhi , Sun Liping , Xu Qian , Gong Yuehua , Jing Jingjing , Dong Nannan , Xing Chengzhong , Yuan Yuan 
Published: August 2018

AbstractMultidimensional interactions of multiple factors are more important in promoting cancer initiation. Gene‐gene interactions between protein‐coding genes have been paid great attention, while rare studies refer to the interactions between encoding and noncoding genes. Our research group previously found encoding gene PGC polymorphisms could affect the susceptibility to atrophic gastritis (AG) and gastric cancer (GC). Interestingly, several SNPs in long noncoding RNA (lncRNA) genes, just adjacent to PGC, were found to be associated with AG risk and GC prognosis afterward. This study aims to explore the SNP interactions between PGC and its neighbor lncRNAs on the risk of AG and GC. Genotyping for seven PGC SNPs and seven lncRNA SNPs was conducted using Sequenom MassARRAY platform in a total of 2228 northern Chinese subjects, including 536 GC cases, 810 AG cases, and 882 controls. We found 15 pairwise PGC‐lncRNAs SNPs had interactions: Five pairs were associated with AG risk, and ten pairs were associated with GC risk. Moreover, two GC‐related interactions PGC rs6939861 with lnc‐C6orf‐132‐1 rs7749023 and rs7747696 survived the Bonferroni correction (Pcorrection = 0.049 and 0.007, respectively). Several combinations showed obvious epistasis and cumulative effects on disease risk. Some three‐way interactions of SNPs with smoking and drinking could also be observed. Besides, a few interacting SNPs showed correlations with the expression levels of PGC protein and related lncRNAs in serum. Our study would provide research clues for further screening combination biomarkers uniting both protein‐coding and noncoding genes with the potential in prediction of the susceptibility to GC and its precursor.
Novel therapeutic roles of MC‐4 in combination with everolimus against advanced renal cell carcinoma by dual targeting of Akt/pyruvate kinase muscle isozyme M2 and mechanistic target of rapamycin complex 1 pathways
Authors: Son Ji Yeon , Yoon Sungpil , Tae In Hwan , Park Yu Jin , De Umasankar , Jeon Yukyoung , Park Young Ju , Rhyu Im Joo , Lee Byung Mu , Chung Kyu‐Huck , Lim Joung Eun , Lee Se Jeong , Lee Hye Won , Kwak Jong Hwan , Kim Hyung Sik , Choi Han Yong 
Published: August 2018

AbstractCurrent clinical trials of new anticancer therapies against metastatic renal cell carcinoma (RCC), including molecular‐targeted therapies, have not shown promise. The purpose of this study was to preclinically assess the antitumor effects of MC‐4, a partially purified material of Artemisia annua L., as a monotherapy or in combination with the known mechanistic target of rapamycin complex 1 (mTORC1) inhibitor, everolimus, against Caki‐1 (Von Hippel‐Lindau (VHL)+/+) and 786‐O (VHL−/−) human RCC cells. MC‐4 monotherapy significantly increased tumor growth inhibition and autophagic cell death in RCC cells in vitro and in vivo. Everolimus led to compensatory Akt activation by inhibiting only mTORC1 signaling pathway. In contrast to everolimus, MC‐4 enhanced phosphatase and tensin homolog expression and reduced its downstream effector, Akt/pyruvate kinase muscle isozyme M2 (PKM2), leading to decreased expression of glucose transporter 1, which is associated with cancer cell metabolism. The synergistic antitumor and anti‐metastatic effects induced by co‐administration of MC‐4 and everolimus involve cell growth inhibition and autophagic cell death via dual targeting of phosphatidylinositol 3‐kinase (PI3K)/Akt/PKM2 and mTORC1. These findings suggest that MC‐4 is a novel Akt/PKM2 inhibitor that can overcome the limitation of existing mTOR inhibitors and can be considered a novel strategy to treat patients with rapidly progressing advanced RCC.
In Vitro Toxicity of Asparagus Saponins in Distinct Multidrug‐Resistant Colon Cancer Cells
Authors: Jaramillo‐Carmona Sara , Guillén‐Bejarano Rafael , Jiménez‐Araujo Ana , Rodríguez‐Arcos Rocío , López Sergio 
Published: August 2018

AbstractColorectal cancer is the third most common cancer in the world. Many efforts have focused on finding natural molecules with potential chemo‐preventive activity due to their low toxicity compared to synthetic drugs. However, comprehensive information on the bioactive fractions and components is still missing. In this study, we developed a method for the quantitative separation and isolation of saponins from asparagus genotypes consisting of an adsorption chromatography and subsequent liquid chromatographic separation on a reversed‐phase column. The saponins isolated were tested for their cytotoxic activity against human colon cancer cell lines, which could develop cross‐resistance to a wide variety of chemotherapeutic drugs. Our results showed that Huétor‐Tájar asparagus saponins (HTSAP), mainly protodioscin and HTSAP‐10 have higher cytotoxic activity than HTSAP‐1, HTSAP‐6, and HTSAP‐8. This study links the potential anticancer effect of asparagus to specific saponins and unveils the triguero Huétor‐Tájar asparagus as a nutraceutical particularly in colon cancer therapies.