bluuebunny/crossref_metadata_2025_split huggingface dataset:
Population pharmacokinetics of artesunate and dihydroartemisinin in pregnant and non-pregnant women with uncomplicated Plasmodium falciparum malaria in Burkina Faso: an open label trial
Authors: Birgersson Sofia , Valea Innocent , Tinto Halidou , Traore-Coulibaly Maminata , Toe Laeticia C. , Hoglund Richard M. , Van Geertruyden Jean-Pierre , Ward Stephen A. , D’Alessandro Umberto , Abelö Angela , Tarning Joel 
Published: March 2019

Background: Malaria during pregnancy is a major health risk for both the mother and the foetus. Pregnancy has been shown to influence the pharmacokinetics of a number of different antimalarial drugs. This might lead to an under-exposure in these patients which could increase the risk of treatment failure and the development of drug resistance. The study aim was to evaluate the pharmacokinetics of artesunate and dihydroartemisinin in pregnant and non-pregnant patients using a population modelling approach. Methods: Twenty-four women in their second and third trimester of pregnancy and twenty-four paired non-pregnant women, all with uncomplicated P. falciparum malaria, were enrolled in this study. Treatment was a fixed-dose combination of oral artesunate and mefloquine once daily for three days. Frequent blood samples were collected and concentration-time data for artesunate and dihydroartemisinin were analysed simultaneously using nonlinear mixed-effects modelling. Results: Artesunate pharmacokinetics was best described by a transit-compartment absorption model followed by a one-compartment disposition model under the assumption of complete in vivo conversion of artesunate into dihydroartemisinin. Dihydroartemisinin pharmacokinetics was best described by a one-compartment disposition model with first-order elimination. Pregnant women had a 21% higher elimination clearance of dihydroartemisinin, compared to non-pregnant women, resulting in proportionally lower drug exposure. In addition, initial parasitaemia and liver status (alanine aminotransferase) were found to affect the relative bioavailability of artesunate. Conclusions: Results presented here show a substantially lower drug exposure to the antimalarial drug dihydroartemisinin during pregnancy after standard oral treatment of artesunate and mefloquine. This might result in an increased risk of treatment failure and drug resistance development, especially in low transmission settings where relative immunity is lower. Trial registration: ClinicalTrials.gov NCT00701961 (19/06/2008)
Human Garden Being in Relax Empty Axis/Empty Space with Suprapto Suryodarmo
Authors: Baxter Paul , Suryodarmo Suprapto 
Published: March 2019

Abstract
Following his keynote workshop at the Dance and Somatic Practices Conference at Coventry University in July 2017, Prapto was interviewed a month later during a workshop in Amsterdam, by Paul Baxter and Sandra Reeve. During the interview Prapto reflects upon his experience in Coventry, his concept of Human Garden Being and the meaning of his movement work.
Hebraica sunt, non leguntur: Some Emendations to Philo by the Late Yehoshua Amir
Authors: Glucker John 
Published: March 2019

Abstract
In a Hebrew translation of some Philonian works, Israeli scholar Yehoshua Amir (formerly Hermann Neumark, 1911–2002) offered a number of emendations, explaining some of them in extensive footnotes. To make some of his suggestions more widely available, I translate here three of his more important notes explaining his emendations, and discuss them with further evidence. They deal with emendations to Migr. 9, Heres 52 f., and Heres 313 f.
Bounded M-O Extended Exponential Distribution with Applications
Authors: Ghosh Indranil , Dey Sanku , Kumar Devendra 
Published: March 2019

AbstractIn this paper a new probability density function with bounded domain is presented. This distribution arises from the Marshall–Olkin extended exponential distribution proposed by Marshall and Olkin (1997). It depends on two parameters and can be considered as an alternative to the classical beta and Kumaraswamy distributions. It presents the advantage of not including any additional parameter(s) or special function in its formulation. The new transformed model, called the unit-Marshall–Olkin extended exponential (UMOEE) distribution which exhibits decreasing, increasing and then bathtub shaped density while the hazard rate has increasing and bathtub shaped. Various properties of the distribution (including quantiles, ordinary moments, incomplete moments, conditional moments, moment generating function, conditional moment generating function, hazard rate function, mean residual lifetime, Rényi and δ-entropies, stress-strength reliability, order statistics and distributions of sums, difference, products and ratios) are derived. The method of maximum likelihood is used to estimate the model parameters. A simulation study is carried out to examine the bias, mean squared error and 95  asymptotic confidence intervals of the maximum likelihood estimators of the parameters. Finally, the potentiality of the model is studied using two real data sets. Further, a bivariate extension based on copula concept of the proposed model are developed and some properties of the distribution are derived. The paper is motivated by two applications to real data sets and we hope that this model will be able to attract wider applicability in survival and reliability.
Long non-coding RNA CHRF promotes proliferation and mesenchymal transition (EMT) in prostate cancer cell line PC3 requiring up-regulating microRNA-10b
Authors: Liu Shuang , Wang Lin , Li Yongwei , Cui Yuanshan , Wang Yongqiang , Liu Chu 
Published: March 2019

Abstract
Despite the advance of diagnosis and treatment for prostate cancer, the prognosis of metastatic prostate cancer is poor. We aimed to explore the functional role of long non-coding RNA cardiac hypertrophy-related factor (lncRNA CHRF) in prostate cancer cells (PC3) as well as the molecular mechanisms. LncRNA CHRF silence repressed cell number (%), down-regulated expression of cyclinD1, CDK4 and CDK6, and promoted apoptosis along with activation of the casapse-3 and caspase-9. LncRNA CHRF promoted mesenchymal transition (EMT), showing down-regulation of E-cadherin and up-regulation of N-cadherin, vimentin and ZEB1. Afterwards, we found miR-10b expression was positively correlated with lncRNA CHRF expression, and miR-10b inhibition could reverse the effects of lncRNA CHRF on PC3 and LNCaP cell proliferation and EMT. Finally, lncRNA CHRF was found to activate the GSK3β/AKT and NF-κB pathways via up-regulation of miR-10b. LncRNA CHRF silence repressed proliferation and EMT while promoted apoptosis in PC3 cells via positive regulation of miR-10b. The GSK3β/AKT and NF-κB pathways were activated by lncRNA CHRF, possibly through up-regulation of miR-10b.
Oxidative Stress Parameters and Its Associations With Arterial Stiffness in Competitive Powerlifting Athletes After 12-Week Supervised Strength Training
Authors: Jürgenson Janno , Serg Martin , Kampus Priit , Kals Jaak , Zagura Maksim , Viru Mehis , Zilmer Kersti , Zilmer Mihkel , Eha Jaan , Unt Eve 
Published: March 2019

Abstract
Jürgenson, J, Serg, M, Kampus, P, Kals, J, Zagura, M, Viru, M, Zilmer, K, Zilmer, M, Eha, J, and Unt, E. Oxidative stress parameters and its associations with arterial stiffness in competitive powerlifting athletes after 12-week supervised strength training. J Strength Cond Res 33(7): 1816–1822, 2019—Available studies have not revealed a clear understanding of the impact of intensive strength training on arterial stiffness and oxidative stress (OxS) parameters, which may have a significant impact on further cardiovascular health of an athlete. The purpose of this study was to evaluate the effect of a 12-week supervised strength training program (SSTP) on oxidative stress indices and its relationship with arterial stiffness in powerlifting athletes. A total of 19 men (28 ± 6 years) exercised for 12 weeks (4 days per week with intensity 60–90% assessed from 1 repetition maximum, 90–120 minutes per session). Oxidative stress parameters and arterial stiffness (SphygmoCor 7.1) were measured before and after SSTP. The study results showed that total peroxide concentration increased and total antioxidant capacity decreased significantly after SSTP. There were no significant changes in carotid-femoral pulse wave velocity (cfPWV) or in the augmentation index. Correlation analysis revealed that the magnitude of the increase of cfPWV was significantly related to the increase of OxS. The current study demonstrated that a 12-week SSTP in powerlifting athletes produced significant changes in OxS indices, which were positively related to increased aortic stiffness. This novel finding may have significant implications about the effect of OxS on cardiovascular health after high-intensity strength training. Furthermore, strength and conditioningcoaches may have to consider the long-term exercise-induced changes in OxS on an individual level, where increased OxS leads to impaired arterial stiffness and cardiovascular health.
Investigation on the Potential Use of Recycled Fine Aggregate to Produce Geopolymer Mortar Mix
Authors: Saha Suman , Rajasekaran Chandrasekaran 
Published: March 2019

Abstract
The utilization of construction and demolition waste (C&DW) partially or fully for various purposes in construction industries is one of the most significant solutions to overcome the scarcity of raw materials and disturbances of the environmental system. On the other hand, geopolymer is being tried to be established as an alternative sustainable binder material for ordinary portland cement. In the present study, with the thought of promoting of sustainability, an attempt has been made to use concrete wastes as recycled fine aggregate (RFA) partially to produce fly ash (FA)–based geopolymer mortar. The workability, water absorption, compressive strength at 3, 7, 28, and 56 days, volume change behavior, and chloride permeability of the produced FA–based geopolymer mortar were determined. The effects of RFA, the ratio of alkali liquid (AL) to FA, and different curing regimes on these properties of mortar mix also discussed. The morphology and microstructures of the samples taken from the mortar mix, which were observed having the highest strength under different curing regimes, were studied using scanning electron microscopy (SEM). The experimental results indicate lower workability, higher water absorption capacity, and higher drying shrinkage of geopolymer mortar mix that has more RFA content in the mix, but the compressive strength of the geopolymer mortar mix started decreasing after a certain percentage of RFA content in the mix. Utilization of that certain percentage of RFA will help us to minimize the consumption of natural fine aggregates and reduce the disturbances generated by unorganized dumping of C&DW.
Improving Energy Efficiency in Wireless Sensor Networks through Virtual-Backbone–Based Topology Control Mechanism
Authors: Sivakumar V. , Janakiraman Subbiah , Chandraprabha K. 
Published: March 2019

Abstract
This article presents a design of a virtual-backbone–based topology control scheme that builds the virtual backbone with the help of localized information. Initially, the dominating set is constructed using spanning tree application. The resultant dominating set spanning tree is further optimized to remove dominant act nodes because, originally, they are the regular nodes, and it forms a small-sized backbone with selected sufficient energy capacity nodes. Then the 3-hop message forward algorithm is used to identify the relay nodes. The roles of the relay nodes are to make the dominating set as a connected dominating set (CDS). Finally, a minimal CDS is formed by a heuristic approach to remove redundant sensors from the CDS.
TheNeurospora crassaStandard Oak Ridge Background Exhibits Atypically Efficient Meiotic Silencing by Unpaired DNA
Authors: Giri Dev Ashish , Pankajam Ajith V , Nishant Koodali T , Kasbekar Durgadas P 
Published: March 2019

AbstractMeiotic silencing by unpaired DNA (MSUD), an RNAi-mediated gene silencing process, is efficient in crosses made in the Neurospora crassa standard Oak Ridge (OR) genetic background. However, MSUD was decidedly less efficient when the OR-derived MSUD testers were crossed with many wild-isolated strains (W), suggesting that either sequence heterozygosity in tester x W crosses suppresses MSUD, or that OR represents the MSUD-conducive extreme in the range of genetic variation in MSUD efficiency. Our results support the latter model. MSUD was less efficient in near-isogenic crosses made in the novel N. crassa B/S1 genetic background, and in N. tetrasperma strain 85. Possibly, in B/S1 and 85, additional regulatory cues, absent from OR, calibrate the MSUD response. A locus in distal chromosome 1R appears to underlie the OR vs. B/S1 difference. Repeat-induced point mutation (RIP) destroys duplicated genes by G:C to A:T mutation of duplicated DNA sequences. Chromosome segment duplications (Dps) dominantly suppress RIP, possibly by titrating out the RIP machinery. In Dp x N crosses, the Dp–borne genes cannot pair properly, hence efficient MSUD, as in OR, silences them and renders the crosses barren. We speculate that the increased productivity engendered by inefficient MSUD enables small duplications to escape RIP.
Depletion of Limiting rDNA Structural Complexes Triggers Chromosomal Instability and Replicative Aging of Saccharomyces cerevisiae
Authors: Fine Ryan D , Maqani Nazif , Li Mingguang , Franck Elizabeth , Smith Jeffrey S 
Published: March 2019

Abstract
Sir2 is a highly conserved NAD+-dependent histone deacetylase that functions in heterochromatin formation and promotes replicative life span (RLS) in the budding yeast, Saccharomyces cerevisiae. Within the yeast rDNA locus, Sir2 is required for efficient cohesin recruitment and maintaining the stability of the tandem array. In addition to the previously reported depletion of Sir2 in replicatively aged cells, we discovered that subunits of the Sir2-containing complexes silent information regulator (SIR) and regulator of nucleolar silencing and telophase (RENT) were depleted. Several other rDNA structural protein complexes also exhibited age-related depletion, most notably the cohesin complex. We hypothesized that mitotic chromosome instability (CIN) due to cohesin depletion could be a driver of replicative aging. Chromatin immunoprecipitation assays of the residual cohesin (Mcd1-Myc) in moderately aged cells showed strong depletion from the rDNA and initial redistribution to the point centromeres, which was then lost in older cells. Despite the shift in cohesin distribution, sister chromatid cohesion was partially attenuated in aged cells and the frequency of chromosome loss was increased. This age-induced CIN was exacerbated in strains lacking Sir2 and its paralog, Hst1, but suppressed in strains that stabilize the rDNA array due to deletion of FOB1 or through caloric restriction. Furthermore, ectopic expression of MCD1 from a doxycycline-inducible promoter was sufficient to suppress rDNA instability in aged cells and to extend RLS. Taken together, we conclude that age-induced depletion of cohesin and multiple other nucleolar chromatin factors destabilize the rDNA locus, which then results in general CIN and aneuploidy that shortens RLS.
Expressions of Gratitude and Medical Team Performance
Authors: Riskin Arieh , Bamberger Peter , Erez Amir , Riskin-Guez Kinneret , Riskin Yarden , Sela Rina , Foulk Trevor , Cooper Binyamin , Ziv Amitai , Pessach-Gelblum Liat , Bamberger Ellen 
Published: March 2019

BACKGROUND AND OBJECTIVES:Exposure to negative social interactions (such as rudeness) has robust adverse implications on medical team performance. However, little is known regarding the effects of positive social interactions. We hypothesized that expressions of gratitude, a prototype of positive social interaction, would enhance medical teams’ effectiveness. Our objective was to study the performance of NICU teams after exposure to expressions of gratitude from alternative sources.METHODS:Forty-three NICU teams (comprising 2 physicians and 2 nurses) participated in training workshops of acute care simulations. Teams were randomly assigned to 1 of 4 conditions: (1) maternal gratitude (in which the mother of a preterm infant expressed gratitude to NICU teams, such as the one that treated her child), (2) expert gratitude (in which a physician expert expressed gratitude to teams for participating in the training), (3) combined maternal and expert gratitude, or (4) control (same agents communicated neutral statements). The simulations were evaluated (5-point Likert scale: 1 = failed and 5 = excellent) by independent judges (blind to team exposure) using structured questionnaires.RESULTS:Maternal gratitude positively affected teams’ performances (3.9 ± 0.9 vs 3.6 ± 1.0; P = .04), with most of this effect explained by the positive impact of gratitude on team information sharing (4.3 ± 0.8 vs 4.0 ± 0.8; P = .03). Forty percent of the variance in team information sharing was explained by maternal gratitude. Information sharing predicted team performance outcomes, explaining 33% of the variance in diagnostic performance and 41% of the variance in therapeutic performance.CONCLUSIONS:Patient-expressed gratitude significantly enhances medical team performance, with much of this effect explained by enhanced information sharing.
Features of herpetofauna dynamics in the Nature Reserve «Dniprovsko-Orilsky» under conditions of climate change
Authors: Gasso V. Ya. , Yermolenko S. V. , Kochet V. M. , Hagut A. M. , Pakhomov O. Ye. 
Published: March 2019

The Nature Reserve «Dniprovsky-Orilsky» occupies unique ecosystems of the floodplain of the middle part of the Dnieper River, where the medium-flooded forests (black poplar and willow forests, elm-Tatarian maple oakeries, and pine forests at the sandy second terrace) predominate. Marshy, wet and dry meadows, sandy steppes, salt marshes, floodplain lakes and isles support the diversity of habitats. Reptiles, like ectothermic organisms, are known to be sensitive to temperature and humidity, which are directly influenced by climate change. Due to the variety of species and their habitats’ conditions, it is important to study the possible effects of climate change on each species and each place of their residence separately. Studies in more or less natural conditions of the Reserve allow minimizing the impact of the anthropogenic factors on the number and diversity of species. To produce accurate inventories we use the method of linear transects created at survey sites modified by Dinesman and Kaletskaya (1952) with a width of transects up to 3 meters. The length of the survey route depended on the availability for an accountant, but was not less than 1.0 km in all cases. The surveys were conducted during the period of maximum daily activity of reptiles in the spring-summer period on specified routes. The density of reptiles was described as the number of individuals per hectare of an averaged ecosystem. In aquatic and wetland ecosystems, the population density of European pond turtle and dice snake were determined as a number of specimens per 1 km of the waterbody’s bankline. During almost 30 years of observation, eight reptile species have been registered on the territory of the Dniprovsky-Orilsky Nature Reserve, among which three species (Coronella austriaca, Natrix tessellata and Dolichophis caspius) have been recorded in the last decade. In recent years (since 1972), the average increase in the temperature of the surface air layer in Ukraine was more than 1 °С. In winter, in the central regions of the country, the highest increase in the average monthly air temperature is observed. The excess reaches 2 °C and more. Climatic changes can be the reason for the invasion and the number growth of the dice snake and the appearance of the Caspian whipsnake within the Reserve. In the context of general climate change, there is a tendency to reduce the population density of the pond turtle, sand lizard and grass snake. At the same time, there is a gradual increase in the number of steppe vipers. Preserving current temperature trends in the coming years can create favourable conditions for another reptile species – the blotched snake (Elaphe sauromates) – to penetrate into the Reserve, but also negatively affect the hygrophilic species. Increasing the risk of summer fires in the Nature Reserve «Dniprovsky-Orilsky» is one of the most threatening factors for the conservation of the terrestrial biota, including reptiles.
The Potential Clinical Implications of Circulating Tumor Cells and Circulating Tumor Microemboli in Gastric Cancer
Authors: Abdallah Emne A. , Braun Alexcia C. , Flores Bianca C.T.C.P. , Senda Laís , Urvanegia Ana Cláudia , Calsavara Vinicius , Fonseca de Jesus Victor Hugo , Almeida Maria Fernanda Arruda , Begnami Maria Dirlei , Coimbra Felipe J.F. , da Costa Wilson Luiz , Nunes Diana Noronha , Dias-Neto Emmanuel , Chinen Ludmilla T. Domingos 
Published: March 2019

Abstract

Background
Gastric adenocarcinoma (GAC) is the third deadliest malignant neoplasm worldwide, mostly because of late disease diagnosis, low chemotherapy response rates, and an overall lack of tumor biology understanding. Therefore, tools for prognosis and prediction of treatment response are needed. Quantification of circulating tumor cells (CTCs) and circulating tumor microemboli (CTM) and their expression of biomarkers has potential clinical relevance. Our aim was to evaluate CTCs and CTM and their expression of HER2 and plakoglobin in patients with nonmetastatic GAC, correlating the findings to clinicopathological data.

Materials and Methods
CTC enrichment was performed with isolation by size of epithelial tumor cells, and the analysis was performed with immunocytochemistry and microscopy. Two collections were made: one at diagnosis (55 samples before neoadjuvant treatment) and one after surgery and before adjuvant therapy (33 samples).

Results
A high detection rate of CTCs (90%) was observed at baseline. We evaluated HER2 expression in 45/55 biopsy samples and in 42/55 CTC samples, with an overlap of 36 subjects. Besides the good agreement observed for HER2 expression in primary tumors and paired CTCs for 36 cases (69.4%; κ = 0.272), the analysis of HER2 in CTCs showed higher positivity (43%) compared with primary tumors (11%); 3/5 patients with disease progression had HER2-negative primary tumors but HER2-positive CTCs. A significant CTC count drop in follow-up was seen for CTC-HER2-positive cases (4.45 to 1.0 CTCs per mL) compared with CTC-HER2-negative cases (2.6 to 1.0 CTCs per mL). The same was observed for CTC-plakoglobin-positive cases (2.9 to 1.25 CTCs per mL).

Conclusion
CTC analysis, including their levels, plakoglobin, and HER2 expression, appears to be a promising tool in the understanding the biology and prognosis of GAC.

Implications for Practice
The analysis of circulating tumor cell levels from the blood of patients with gastric adenocarcinoma, before and after neoadjuvant treatment, is useful to better understand the behavior of the disease as well as the patients more likely to respond to treatment.