bluuebunny/crossref_metadata_2025_split huggingface dataset:
Unveiling Fv1's Potential: Insights into its Interaction with the HIV-1 Capsid
Authors: Dehghani Behzad , Hashempour Ava 
Published: November 2024

Abstract

Virus susceptibility factor 1 (Fv1) serves as the prototype restriction factor guarding against infection by murine leukemia virus (MLV). Analysis of the Fv1 sequences revealed several residues in the C-terminal region that had undergone positive selection during evolution and might have played a role in various retroviral infections. For the first time, various bioinformatic tools have been applied to reveal specific residues involved in the interaction between Fv1 and the HIV-1 capsid as the target. Molecular dynamics (MD) simulation analysis of the Fv1-capsid complex confirmed the stability of the protein-protein complex. Docking and molecular dynamic simulation analyses demonstrated the potential of Fv1 to inhibit HIV-1 infection and supported the possibility that the HIV-1 capsid could be a target for novel anti-HIV medications. Furthermore, we revealed conserved regions, postmodification sites, and secondary and tertiary structures, which provided valuable data about the nature of the FV1 protein.
Analgesia and sedation in premature infants receiving invasive ventilation: a systematic scoping review.
Authors: Moultrie Fiona , Durrmeyer Xavier , Bosch Gerbrich E. van den , Tauzin Manon , Roué Jean Michel , Olsson Emma , Cobo Maria M , Baxter Luke , Iyer Samyuktha , Bhatt Aomesh , Simons Sinno H.P. , Slater Rebeccah 
Published: November 2024

Abstract

The purpose of this scoping review is to assess the risks and benefits of providing analgesic and sedative drugs to ventilated premature infants. We sourced primary empirical research reporting outcomes related to the use of pharmacological analgesics and sedatives in ventilated premature infants. We included articles published in any language in peer-reviewed journals before February 2024 from MEDLINE, Embase, Web of Science, Cochrane Library, and Google scholar databases. Morphine was the most studied drug (39 studies), followed by fentanyl (19 studies). Midazolam (8 studies) and dexmedetomidine (3 studies) were the most frequently studied sedatives. Analgesic efficacy was more consistently reported for fentanyl than morphine. The sedative effect of opioids was rarely assessed. Respiratory, cardiovascular, gastrointestinal, neurological and neurodevelopmental risks were unclear for all opioids. Alternative synthetic opioids and midazolam appear to be associated with significant risks in the absence of clear benefits. Dexmedetomidine shows encouraging but limited results and merits further investigation as an opioid-sparing adjunct. Overall, fentanyl appears to have the best efficacy and safety profile for analgosedation in this patient population. This scoping review will support clinicians in their analgosedative management of ventilated premature infants and identifies research gaps and priorities.
WITHDRAWN: Gas Recycling Optimization in Gas Condensate Reservoirs Using 3D Compositional Modeling
Authors: Kasem Mohamed Raafat , Khattab Hamid Mohamed , Wahba Ali Moustafa 
Published: November 2024

Abstract

Gas condensate reservoirs present unique production challenges due to condensate dropout in reservoir pores when the pressure drops below the dew point. This immobile condensate accumulation reduces well productivity. Dry gas recycling is a widely recognized enhanced production technique to mitigate this issue and maximize condensate recovery. This study employs a three-dimensional compositional model to optimize condensate recovery by varying the gas recycling ratio in reservoirs of different qualities and gas compositions (with varying condensate yields). The analysis considers both vertical and horizontal production well configurations. Initially, a depletion scenario was modeled with five wells producing under natural depletion as the base case. Subsequently, a dry gas recycling process was applied with recycling ratios ranging from 0 to 1, achieved by converting one producer into an injector in a crestal injection pattern. Horizontal wells were also introduced to evaluate the impact of well geometry on recovery performance. The findings indicate that the optimum dry gas injection ratio increases with higher condensate yields. Specifically, the optimal ratio rises from 50% for gas with a condensate yield of 20 STB/MMSCF to 75% for gas with 60 STB/MMSCF. Additionally, reservoir quality and well geometry significantly influence performance. For high-quality reservoirs, horizontal wells outperform vertical wells for high-condensate-yield gas reservoirs. While for low-quality reservoirs: Vertical wells are more effective than horizontal wells for high-condensate-yield gas reservoirs. These results provide guidelines for optimizing dry gas injection ratios across a wide range of reservoir qualities and gas yield contents to maximize recovery.
ТРАНСДИСЦИПЛИНАРНОСТЬ В ИСТОРИЧЕСКОМ ЗНАНИИ
Authors: К.В. Хвостова 
Published: November 2024

Статья характеризует трансдисциплинарность в истории как проблему, относящуюся к связи логического и интуитивного знаний. Автор обращается к своей собственной научной практике и иллюстрирует специфические черты исторической трансдисциплинарности примерами из византийской истории. Понятие «цивилизация» характеризуется как трансдисциплинарное. В статье показана роль трансдисциплинарности в расширении границ исторического знания.
The article considers transdisciplinarity in history as a problem related to the connection between logical and intuitive knowledge. The author turns to his personal scientific practice and illustrates the specific features of historical transdisciplinarity by examples of Byzantine history. The author characterizes the concept of civilization as transdisciplinarian notion. The article demonstrates the role of transdisciplinarity in enlargement the limits of the historical knowledge.
ИДЕНТИТАРНЫЕ ПРОЦЕССЫ В СРЕДНЕВЕКОВОМ УЭЛЬСЕТЕРМИНОЛОГИЯ, ДИСКУРСЫ И СИТУАЦИЯ БИЛИНГВИЗМА
Authors: С.Е. Федоров 
Published: November 2024

Статья посвящена анализу идентитарных процессов, протекавших в средневековом Уэльсе в условиях активного для местного населения билингвизма[2]. Сосредотачивая свое внимание на вернакулярных и ориентированных на использование латинских терминов ресурсах, автор стремиться определить семантическое поле обозначения «Kymry», а также используемых за пределами этой традиции латинских определений. Обращая внимание на полисемию термина, автор подчеркивает наличие тенденции на последовательное разграничение вернакулярных и ориентированных на латинские определения языковых ресурсов и как результат – формирующихся на их основе дискурсов. Практики, отталкивавшиеся от такого разграничения, акцентировали его как принципиальное, но при этом неизбежно адаптировались к условиям активного для этого региона Британских островов двуязычия. В этом смысле в основанных на противоположных приоритетах дискурсах могли возникать и возникали поясняющие такие разграничения лексические комбинации, а традиции в свою очередь могли переплетаться. В том случае, когда подобного рода пояснения несли в себе значения внешнего характера (к примеру, производную от wēalas терминологию), возникающий таким образом эффект свидетельствовал о дискурсивной аккультурации образованной части туземного населения, но не затрагивал при этом свойственные «валлийскому» дискурсу бриттские акценты.
The evidence of written records and literary texts reveals a complex network of cultural and linguistic negotiations in Medieval Wales and England, in which the terms of ethnicity and subsequent discourses were formed and furthered. Diglossic combinations played a role of a crucial indicator of binary split between the vernacular and Latin language resources. Bilingualism, which indicates the native viewpoint on ethnicity and occupied territory, is hard to separate from a more general historical context where instead of the absent terms “Wales” and “the Welsh” prevailed the “Britain” and the “Britons”. Aimed at analysis of the semantic field of “Kymry”, the article concentrates on the formation of both the vernacular and Latin discourses and shows how its meaning was crystalized through their interaction. Treating British rhetoric as pervading much of the corpus of vernacular literature, the author underlines that ethnic and territorial definitions became clearer only after an introduction of wēalas based terminology. Limited to the exterior discourse these clarified meanings were not overriding and did not cross its line.
ДИТРИХ ШЕФЕР – ИСТОРИК КАК ВОСПИТАТЕЛЬ НАЦИИВ ВИЛЬГЕЛЬМОВСКОЙ ГЕРМАНИИ
Authors: Е.В. Киктева 
Published: November 2024

Статья посвящена научной и политической деятельности Дитриха Шефера, немецкого историка-медиевиста конца XIX – начала XX в., образцового представителя немецкой академической элиты. Представления Шефера об этосе ученого служили основой его публичной активности. В политике профессор стремился продвигать собственные идеи, далекие от конъюнктурных соображений. И в своей пропагандистской деятельности, подводя читателя к политическим идеям на основании исторических фактов, Шефер предстает не полемистом, а учителем немецкой нации.
The article is focused on Dietrich Schäfer, the German historian-medievalist of the late 19th – the early 20th c. The main emphasize is on academic and political practices, considering him as an example of a German academic elitist. Schäfer’s political activism was based on his beliefs about researcher’s ethos. Professor sought to provide his own ideas in politics, which had been far from reasons of political conjuncture. His political works are not clearly divided from the popular books, and Schäfer, engaged in agitational activity, came across not as a polemist but as a teacher or a mentor of the German nation, who went from historical facts to the political ideas.
СОВРЕМЕННАЯ ПОЛИТИЧЕСКАЯ ИСТОРИЯ ВО ФРАНЦИИКАК ПРОЕКТ ИСТОРИЧЕСКОГО СИНТЕЗА
Authors: А.Ю. Веревкин 
Published: November 2024

В последние десятилетия политическая история во Франции стала в полном смысле современной областью исторической науки. После длительного периода дискредитации она смогла обогатить свой методологический арсенал, расширить предметную область за рамки государственных институтов и публичного права, увеличить хронологический масштаб исследований. Автор анализирует причины подъема политической истории. В противовес объяснениям на уровне общих тенденций в исторической дисциплине, основное внимание уделено собственному вкладу историков политики в теоретическое развитие своей области. В частности, показано ключевое значение их подхода к трактовке исследовательского объекта.
During last three decades political history is proving to be a fully pertinent field of the French historical science. After a long period of profound discredit French political history has managed to enrich its methodology with resources of the adjacent disciplines, transcended its traditional boundaries of state institutions and public law and developed research technics for wide temporal scales. Thus French political history shows basic capacities for so-called historical synthesis, highly in demand in France after decline of the classic social history. This paper is dedicated to the analysis of causes for the recent rise of the political history in France. This paper is concentrated on the proper theoretical work of political historians promoting their own field, rather than on any explanation deriving from a diagnosis of the tendencies on the level of the whole historical discipline. In particular, this paper shows crucial importance of a certain manner of political historians to define the field of research of political history.
УСТАВ НЕМЕЦКОГО ОРДЕНА И ПОПЫТКАЕГО РЕДАКТИРОВАНИЯ В XV ВЕКЕРЕФОРМА ВЕРХОВНОГО МАГИСТРА ГАНСА ФОН ТИФЕНА
Authors: М.Б. Бессуднова 
Published: November 2024

Создание новой редакции устава Немецкого ордена, инициированное в 1492 г. верховным магистром Гансом фон Тифеном, явилось попыткой сохранить орденское государство с присущими ему коллегиальным правлением и корпоративной собственностью. Крестоносная парадигма и приверженность старинным уставным требованиям, присутствующие в программе Тифена, не могут восприниматься как доказательства ее анахроничности и отсутствия политической взвешенности, поскольку сохранение за орденом статуса государя достигалось незыблемостью папских и императорских привилегий, пожалованных ему в эпоху крестовых походов. Устав содержал определенный поведенческий код, который служил ордену доказательством сохранения его изначальной, крестоносной природы. Однако старинные нормы «благочестия» и «послушания» стали восприниматься как залог добросовестного исполнения рыцарями их административных функций, а их «бедность» гарантией сохранения орденом его собственности.
The effort of Grand Master Hans von Tiefen to create a new version of the Statutes of the Teutonic Order in 1492 was the last attempt to preserve Order’s state in Prussia with its collegial governance and corporate property. The crusading paradigm and the commitment to the statutory requirements, a typical of the program of Tiefen, should not be taken as evidence of its anachronism and the lack of political balance. The long-term sovereign status (Landsherr) of the Teutonic Order had been depended not only on the inviolability of all Papal and imperial privileges granted the Teutonic Knights during the Crusades, but mostly on their compliance with the generally accepted notions of sovereigns. Thus the Statute contained certain behavioral code for the Teutonic Knights and also served as the evidence of preservation of their crusading nature. However, the content of the definitions of "piety" and "obedience" started to work as a guarantee of the performance of administrative functions by the fellow knights, and their "poverty" guaranteed the preservation of the property by the Order.
Natural Language Processing and Social Determinants of Health in Mental Health Research: AI-Assisted Scoping Review
Authors: Scherbakov Dmitry A , Hubig Nina C , Lenert Leslie A , Alekseyenko Alexander V , Obeid Jihad S 
Published: November 2024

Abstract

Background
The use of natural language processing (NLP) in mental health research is increasing, with a wide range of applications and datasets being investigated.

Objective
This review aims to summarize the use of NLP in mental health research, with a special focus on the types of text datasets and the use of social determinants of health (SDOH) in NLP projects related to mental health.

Methods
The search was conducted in September 2024 using a broad search strategy in PubMed, Scopus, and CINAHL Complete. All citations were uploaded to Covidence (Veritas Health Innovation) software. The screening and extraction process took place in Covidence with the help of a custom large language model (LLM) module developed by our team. This LLM module was calibrated and tuned to automate many aspects of the review process.

Results
The screening process, assisted by the custom LLM, led to the inclusion of 1768 studies in the final review. Most of the reviewed studies (n=665, 42.8%) used clinical data as their primary text dataset, followed by social media datasets (n=523, 33.7%). The United States contributed the highest number of studies (n=568, 36.6%), with depression (n=438, 28.2%) and suicide (n=240, 15.5%) being the most frequently investigated mental health issues. Traditional demographic variables, such as age (n=877, 56.5%) and gender (n=760, 49%), were commonly extracted, while SDOH factors were less frequently reported, with urban or rural status being the most used (n=19, 1.2%). Over half of the citations (n=826, 53.2%) did not provide clear information on dataset accessibility, although a sizable number of studies (n=304, 19.6%) made their datasets publicly available.

Conclusions
This scoping review underscores the significant role of clinical notes and social media in NLP-based mental health research. Despite the clear relevance of SDOH to mental health, their underutilization presents a gap in current research. This review can be a starting point for researchers looking for an overview of mental health projects using text data. Shared datasets could be used to place more emphasis on SDOH in future studies.
Clinical portrait of a patient with acute coronary syndrome and type 2 diabetes mellitus: a novel strategy for the diagnosis, prognosis and treatment
Authors: Shved M.I. , Yastremska I.O. , Levytska L.V. , Kuchmiy V.Yu. , Prokopovych O.A. , Kitsak Ya.M. , Liakhovych R.M. 
Published: November 2024

Background. Patients with type 2 diabetes mellitus (T2DM) have a two-fold risk of coronary artery disease (CAD), and their myocardial infarction-associated mortality is 2–4 times higher compared to patients with intact carbohydrate metabolism. The purpose of the study: to determine the impact of type 2 diabetes on the severity of clinical course, changes in laboratory and instrumental findings, the prognosis and treatment strategy selection in patients with acute coronary syndrome (ACS). Materials and methods. We have examined 75 patients with ACS, which has developed on the background of T2DM (the main group), and 28 patients with ACS without T2DM (the control group). ACS with T2DM was substantially more frequent (84 % of cases) in young to middle-aged males (up to 60 years of age) who predominated compared to female patients in a 4.8 : 1 ratio. It was typical for these patients to have frequent comorbid conditions, namely: hypertension (94.7 %), metabolic syndrome (85.3 %), chronic kidney disease (30.7 %), chronic obstructive pulmonary disease (29.3 %), thyroid dysfunction (22.7 %), and such CAD risk factors (and their combinations in 89.3 % of cases) as atherogenic dyslipidemia (96.0 %), tobacco smoking (34.7 %), excessive alcohol use (32.0 %), family history of CAD and T2DM (29.3 and 61.3 % of patients, respectively). Results. The characte­ristic clinical feature in a patient with ACS and T2DM is a severe condition, which is due to a combined multi-vascular involvement of coronary arteries (which is 10.5 times more frequent in these patients) and larger volumes of myocardial necrosis. Such individuals have more pronounced manifestations of necrosis-resorption syndrome, a significant increase in left ventricular myocardial mass and volume due to an increase in diastolic and systolic dimensions, which suggests hypertrophy and cardiac remodeling with impaired systolic function (ejection fraction of less than 50 %) and impaired diastolic function; the latter is considered an impairment of relaxation processes. Conclusions. The clinical portrait of patients with ACS developed on the background of type 2 diabetes is characterized by the following features: men under 60 years of age with comorbid conditions and multiple risk factors for coronary artery disease, multivessel and hemodynamically severe coronary lesions (more than 33 points on the SYNTAX scale), large volume of myocardial necrosis, which determines the atypicality and severity of the disease, high grade of heart failure, a significantly higher incidence of life-threatening complications, and a high risk (over 160 points on GRACE score) of cardiac death.
Contaminación microbiológica en agua potable de localidades rurales en el municipio de Ahome, Sinaloa, México
Authors: Ávila-Díaz Jeován Alberto , Arciniega-Galaviz Marco Arturo , Moreno-Rentería Karla Judith , Llanes-Cárdenas Omar 
Published: November 2024

Las poblaciones rurales del municipio de Ahome, Sinaloa, presentan cierta prevalencia de enfermedades relacionadas con problemas gastrointestinales, razón que motivó la realización de este estudio, para determinar la calidad microbiológica del agua potable, como uno de los posibles factores diseminadores de patógenos. Se evaluó la calidad sanitaria del agua potable proveniente de la llave, mediante la detección de microorganismos indicadores (coliformes fecales termotolerantes) y la concentración de cloro, en 15 comunidades rurales en el municipio de Ahome, Sinaloa. Las bacterias coliformes fecales termotolerantes se aislaron y detectaron por el método de filtración por membrana. El 80 % de las comunidades rurales mostraron resultados positivos para coliformes fecales termotolerantes (1- 250 UFC mL-1) en muestras de agua de la llave del patio, aunque no fue posible identificar a Escherichia coli. Con base en de los resultados, se evidencia la necesidad de contar con mecanismos de control de calidad y saneamiento del agua más eficientes en las zonas rurales consideradas en este estudio, ya que el proceso de cloración no es efectivo y, por lo tanto, es necesario que se intensifique la vigilancia en las redes de distribución de agua, para disminuir la incidencia de enfermedades relacionadas con patógenos en agua para consumo humano.
Receita Contábil, um conceito com diferentes mensurações nas práticas das contabilidades, financeira e tributária
Authors: Farias Manoel Raimundo Santana , Pires André Luis de Moura 
Published: November 2024

O objetivo deste estudo foi caracterizar o conceito de receita como primário ou fundamental da contabilidade, do qual decorrem diferentes critérios de mensuração nas aplicações da contabilidade financeira e da contabilidade tributária, mas todos aplicações do mesmo conceito referencial: receita contábil. A caracterização foi baseada na semântica filosófica[1], especificamente o Significado semântico de receita, composto pela denotação (Referência) e pela conotação (Sentido). A justificativa para o estudo é que a distinção entre o conceito de receita das suas aplicações evita o equívoco de pretender distinguir a receita contábil da receita tributável, porque receita é um conceito contábil, isto é, receita contábil é um gênero, enquanto receita tributável é uma espécie de receita. Em síntese, o que se expõe é que há um conceito “receita contábil”, com suas diferentes aplicações, que, entretanto, não implicam em vários conceitos de receita e sim várias definições indicadoras da receita contábil. Ou seja, fundamentalmente, não há dois gêneros de receita: receita contábil e receita tributável, porque a receita tributável é uma espécie de receita contábil, especificamente apurada para fins de tributação. Portanto, temos: a) receita contábil (gênero); b) receita contábil financeira (espécie 1), mensurada de acordo com conceitos econômicos; e, c) receita contábil tributável (espécie 2), mensurada de acordo com políticas próprias - legislação tributária.

Palavras-Chave: Receita contábil. Teoria da Contabilidade. Contabilidade financeira. Contabilidade tributária. Receita contábil tributável.

[1] Semântica filosófica – a disciplina que estuda os conceitos de referência, intensão, sentido, significado, representação, interpretação, verdade e toda sua parentela. Os resultados desse estudo deveriam ajudar os cientistas a decidir ao que certas teorias se referem, assim como exatificar alguns dos conceitos intuitivos que utilizam, tais como os de conteúdo, contexto e verdade parcial. (BUNGE, 2006, p. 350).