bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical relevance of intracellular vascular endothelial growth factor levels in B-cell chronic lymphocytic leukemia
Authors: Aguayo Alvaro , O'Brien Susan , Keating Michael , Manshouri Taghi , Gidel Cristi , Barlogie Bart , Beran Miloslav , Koller Charles , Kantarjian Hagop , Albitar Maher 
Published: October 2019

AbstractStrong evidence exists for an association between high vascular endothelial growth factor (VEGF) levels and poor prognoses in patients with solid tumors and acute leukemia. Using Western blot analysis and solid-phase radioimmunoassay, we measured cellular VEGF levels in B-cell chronic lymphocytic leukemia (CLL) samples from 225 patients and correlated these levels with disease characteristics and prognoses. The median VEGF level in CLL samples was 7.26 times the median level detected in normal peripheral blood mononuclear cells. Patients with lower levels of VEGF protein showed a trend toward shorter survival (P = .07). However, in a subgroup of CLL patients with good prognoses or early-stage disease (Rai stages 0-II, Binet stages A,B; β2-M ≤ 2.8 mg/dL), lower levels of VEGF were associated with shorter survival times. For the entire group of patients, no correlation was found between VEGF levels and β2-M levels or Rai and Binet stage. Most samples from patients with CLL expressed the 43-kd VEGF isoform in addition to the commonly expressed 45-kd isoform. It remains to be seen whether the expression of the 43-kd isoform is responsible for this reversed correlation with outcome.
Evidence that juvenile myelomonocytic leukemia can arise from a pluripotential stem cell
Authors: Cooper Laurence J. N. , Shannon Kevin M. , Loken Michael R. , Weaver Molly , Stephens Karen , Sievers Eric L. 
Published: October 2019

Abstract
Children with neurofibromatosis type 1 (NF1) carry germline mutations in one allele of the NF1 gene and are predisposed to myeloid malignancies, particularly juvenile myelomonocytic leukemia (JMML). Disruption of the remaining NF1 allele can be found in malignant cells. Flow cytometric cell sorting techniques to isolate the malignant cell populations and molecular genetic methods to assay for somatic loss of the normal NF1 allele were used to study an unusual child with NF1 and JMML who subsequently had T-cell lymphoma. The data show that malignant JMML and lymphoma cells share a common loss of genetic material involving the normal NF1gene and approximately 50 Mb of flanking sequence, suggesting that the abnormal T-lymphoid and myeloid populations were derived from a common precursor cell. These data support the hypothesis that JMML can arise in a pluripotent hematopoietic cell.
Comparison of sensitivity to ultraviolet B irradiation between human lymphocytes and hematopoietic stem cells
Authors: Azuma Hiroshi , Ikebuchi Kenji , Yamaguchi Miki , Murahashi Hideaki , Mogi Yuko , Sato Norihiro , Fujihara Mitsuhiro , Hirayama Fumiya , Ikeda Hisami 
Published: October 2019

Abstract
To investigate the clinical applicability of prophylaxis of post-transplant graft-versus-host disease by UV-B irradiation of stem cell preparations, the UV-B sensitivities of human lymphocytes and primitive hematopoietic progenitors were compared. The mononuclear cell fractions (MNC) derived from human cord blood and granulocyte–colony-stimulating factor–mobilized peripheral blood were used. After UV-B irradiation, lymphocyte proliferation ability, hematopoietic colony-forming cells, and apoptotic cells were analyzed. At a dose of 33 J/m2, significant differences were observed in the residual percentages of hematopoietic progenitors and lymphocyte functions [ANOVA, F (5,46) = 19.4; P &lt; .0001], and the difference between CFU-C (85.2% + 24.0%; n = 8) and MLR (12.7% + 12.6%; n = 10) was significant (P &lt; .0001). There were no significant differences in the residual percentages of CFU-C, HPP-CFC, and LTC-IC. Percentages of annexin V-positive cells in the total MNC and the CD34+cell population in MNC after UV-B irradiation were 69.8% and 18.7%, respectively. In conclusion, there was a range of UV-B doses over which T lymphocytes were inactivated but hematopoietic progenitors, including HPP-CFC and LTC-IC, were preserved.
A child with Gradenigo syndrome presenting with meningism: a case report
Authors: Athapathu A. S. , Bandara E. R. S. , Aruppala A. A. H. S. , Chandrapala K. M. A. U. , Mettananda Sachith 
Published: October 2019

Abstract

Background
The symptoms of meningitis which include fever, headache, photophobia and irritability along with abducens nerve palsy pose a diagnostic dilemma requiring urgent attention. Here we report how such a dilemma was methodically and sequentially resolved using anatomical knowledge supported by neuroimaging and the eventual diagnosis of Gradenigo syndrome was made.

Case presentation
A 6-year-old previously healthy boy from Sri Lanka presented with high grade fever, headache, photophobia and left eye pain for 10 days and diplopia for 2 days duration. Neurological examination was unremarkable except for left sided abducens nerve palsy. He had high inflammatory markers and white blood cell count. A tentative differential diagnosis of acute bacterial meningitis complicated by cerebral oedema, acute hydrocephalus or cerebral abscess was made. However, non-contrast CT brain, cerebrospinal fluid analysis and electroencephalogram were normal leading to a diagnostic dilemma. MRI brain with contrast performed 3 days later due to limited resources revealed left mastoiditis extending to petrous temporal bone confirming Gradenigo syndrome.

Conclusion
This case report highlights the importance of a thorough physical examination in children presenting with unrelated neurological symptoms and signs. Unilateral abducens nerve palsy raises the suspicion of increased intracranial pressure and neuroimaging is vital in diagnostic uncertainties. Gradenigo syndrome emphasises the importance of incorporating anatomical knowledge into clinical practice.
Book Reviews
Authors: Lewis Peter , MacLennan Anne F. , McHugh Siobhan 
Published: October 2019

The Cultural Work of Community Radio, Katie Moylan (2019) Rowman and Littlefield, 180 pp., ISBN: 978-1-78348-932-9, h/bk, £97.05, e-book, £41.52
A Companion to the History of American Broadcasting, Aniko Bodroghkozy (ed.) (2018) Hoboken, NJ: John Wiley & Sons Inc., 512 pp., ISBN: 978-1-11864-615-1, h/bk, $215; e-book $172.99
Podcasting: New Aural Cultures and Digital Media, Dario Llinares, Neil Fox and Richard Berry (eds) (2018) Cham: Palgrave Macmillan, 332 pp., ISBN: 978-3-31990-055-1, p/bk, £22.49, e-book, £21.37
Podcasting: The Audio Media Revolution, Martin Spinelli and Lance Dann (eds) (2019) London and New York: Bloomsbury Academic, 272 pp., ISBN: 978-1-50132-868-8, p/bk, £19.99, e-book, £14.03
MURATTAL DAN MUJAWWAD AL-QUR’AN DI MEDIA SOSIAL
Authors: Masrurin ‘Ainatu 
Published: October 2019

Qur’an as self-referential text within the word Quran and Qul represents the moral dimension involved. It is a dimension when the Quran frequently is applied as a narrative object in daily life by which, according to Frédéric Deny, it is called Performative. In aesthetic reception discourse, Qur’an as a text is placed as an object approached beautifully. For instance, it’s voiced by sound and rhythm called murattal or Mujawwad. The oldest quranic recording is found in 1855 by S Hurgronje in which it was a starting point for the Quran to recept digitally in media matters. Around 2000, Quranic Aesthetic reception in media tools Was widespread massively, then reading Qur’an in this time using Rythm isn't a matter to be coached directly. By phenomenological approach, this research tries to mapping the typology as well as the history of the reader (Qori) who changes to use social media as a listener and appreciator by uploading his/her reading. The result shows that three aspects are influencing the reader's acts in social media, 1) to show the existence of the Quran 2) religious narcism, 3) authoritative freedom. Keyword: Performative, Aesthetic Reception, Qari’, Social Media
Crystal structure of 2-[(1E)-{[1,3-dihydroxy-2-(hydroxymethyl)propan-2-yl]iminiumyl}methyl]-5-(dodecyloxy)benzen-1-olate, C23H39NO5
Authors: Lee See Mun , Lo Kong Mun , Tiekink Edward R.T. 
Published: October 2019

Abstract
C23H39NO5, monoclinic, P21/c (no. 14), a = 26.1698(4) Å, b = 9.4863(2) Å, c = 9.0929(2) Å, β = 97.376(2)°, V = 2238.67(8) Å3, Z = 4, R
gt(F) = 0.0539, wR
ref(F
2) = 0.1580, T = 100(2) K.
Iconic processes and intermediality in the photobooks Silent Book and Sí por Cuba
Authors: Vitorio Ana Paula , Queiroz João 
Published: October 2019

Abstract

Silent Book and Sí por Cuba are paradigmatic examples of photobooks. Those two works are analyzed in this article based on intermedial studies and on C. S. Peirce’s semiotic. As a result, we observe properties and material components of the book working as iconic processes of the photos and of the relationship between them. It constrains interpretive semiotic behavior and reveals certain characteristics of those photographic images. In addition to identifying and presenting examples of it, we demonstrate how the pairing of two or more photos enables semiosis in which the referenced object is developed by the relations between photographs.
Der Beitrag von Infrastrukturgenossenschaften zur Daseinsvorsorge
Authors: Kluth Winfried 
Published: October 2019

Zusammenfassung
Die Propagierung der eingetragenen Genossenschaft als Instrument der Förderung bürgerschaftlichen Engagements im Bereich der Daseinsvorsorge durch den Bundesgesetzgeber wird in der Literatur wegen der damit verbundenen Orientierung an nicht direkt mitgliederbezogenen Interessen kritisiert. Der Beitrag geht auf diese Kritik ein und zeigt auf, warum es gute Gründe gibt, die eG im Bereich der kommunalen Daseinsvorsorge stärker als bisher zu nutzen.
Hypertension specific patient-reported outcome measure. Part III: validation, responsiveness and reliability assessment
Authors: Ionov M. V. , Zvartau N. E. , Dubinina E. A. , Khromov-Borisov N. N. , Tregubenko I. A. , Konradi A. O. 
Published: October 2019

Aim. Health-related quality of life in patients with arterial hypertension (HTN) is still determined by only generic patient-reported outcome measures (PROMs), although disease-specific ones are more reliable and highly valid. Previously, we reported the results of development and item-selection process of the new Russian HTN-specific PROM. The purpose of this last stage was to confirm validity, reliability, responsiveness and sensitivity of the scale and to present its final version.Material and methods. Analysis was done using data from a mass survey of patients with Grades 1-3 HTN (n=359, aged 25 to 91 y. o.) and healthy volunteers (n=48, aged 23 to 65 y.o), 407 returned questionnaires. We conducted two exploratory factor analyses (EFA) with the intermediate version of the PROM (80 questions, 20 of them HTN-specific). The Cattel’s scree test was used to select the optimal number of factors. After removing the items with a low factor loadings, a confirmatory factor analysis (CFA) was performed to assess the model’s fitindexes adequacy. The core indexes to be measured were SRMR, RMSEA, CFI. Finally, the PROM’s reliability (Cronbach’s α and McDonald’s ω) and criterion validity (responsiveness) were evaluated.Results. Both EFA with oblique and varimax rotation showed 35 questions have factor loadings ≥0,5 and assigned to one of 5 factors. The basic structure of the PROM was retained for further CFA. Most of indices of fit measured met the requirements: SRMR was 0,08, RMSEA was 0,07 (90% CI (0,07-0,08)) and CFI was 0,08, which confirms the construct validity. Both Cronbach’s α and MacDonald’s ω of each of the domains were ≥0,80 and the whole scale was 0,89 confirming satisfactory reliability. Scores of the questionnaire were positively correlated with the severity of HTN (p<0,001 for Grades 1-3 HTN) and between HTN and non-HTN patients (p=0,01 and 0,04 in psychologic and social domains respectively).Conclusion. Sequentially addressing of exploratory and confirmatory factor analyses and assessment of reliability and responsiveness allowed to form the final version of the patient-reported outcome measure for arterial hypertension. The new Russian-language questionnaire is a useful and feasible tool for routine practice and clinical trials.
EFFECT OF ORGANIZATIONAL JUSTICE, CONFLICT MANAGEMENT, COMPENSATION, WORK STRESS, WORK MOTIVATION ON EMPLOYEE PERFORMANCE SALES PEOPLE
Authors: Wiradendi Wolor Christian , Supriyati Yetti , Purwana Dedi 
Published: October 2019

Purpose: This study aimed to investigate the effect of organizational justice, conflict management, compensation, work stress, work motivation on the employee performance of sales people. Methodology: The sampling technique the researchers used is proportional random sampling. In this study, researchers used 200 samples taken. The number of populations is one dealer with four different ones, so the sample is also different. The number of sales people who were sampled 200 respondents from 302 salespeople. The sample size is proportional to the population at each dealer. Statistical tools used in this research are the Structural Equation Model (SEM). Data are analyzed by using statistical software LISREL 8.5. Result: This study resulted in the finding that organizational justice positive effect on employee performance. Conflict management positive effect on work motivation. Conflict management positive effect on employee performance. Compensation positive effect on work motivation. Compensation positive effect on employee performance. Work stress positive effect on employee performance. Work motivation positive effect on employee performance. Conflict Management also has an indirect influence through work motivation. Compensation also has an indirect influence through work motivation. Applications: This research can be used for the universities, teachers and education students. Novelty/Originality: In this research, the model of the effect of organizational justice, conflict management, compensation, work stress, work motivation on employee performance sales people are presented in a comprehensive and complete manner.
TOURISM ATTRACTION IN RUSSIAN REGIONS IN CYBERSPACE: NEW TENDENCIES OF TOURISM MEDIA MARKETING
Authors: V. Frolova Elena , V. Rogach Olga , M. Ryabova Tatyana 
Published: October 2019

Purpose: The present study was aimed at investigating the characteristics of tourist media content in cyberspace. The characteristics regarding the reflection and survey of tourist attractions in the Russian regions were also analyzed.
Methodology: Data on the empirical research field was collected through tourist feedback on the Internet, as well as other social studies studied the wide-ranging relationship of users with media space. Visual media and contemporary time were identified among the most well-known sources of information about services and tourist facilities. Available sentiments with a variety of information available in cyberspace included: inclusive communication, comprehensiveness, pragmatism and using literal communication and providing easy access. In this paper, the outcomes of the outlook for tourism advancement by the help of the media were also discussed.
Result: Tourism media, as well as the expansion flow and evolution regarding receiving and construction and increasing the information to respond to the key questions of the development of the tourism industry, were studied such as infrastructure equipment and services and the potential of the tourist industry. The content of cyber media was found to be helpful in consolidating the issues and modes and practical cases of various tourist groups, as well as representing the expectations and interests of tourism industry consumers. The popularity of media content has created vast opportunities for creators and users of information including personalization of demands, flexible communication, and the feasibility of introducing characters by presenting in virtual online space about the time spent on holidays.
Applications: This research can be used for the universities, teachers and education students.
Novelty/Originality: In this research, the model of the tourist attraction in Russian regions in cyberspace: new tendencies of tourism media marketing is presented in a comprehensive and complete manner.
Propuesta de enseñanza de inglés para escuelas normales
Authors: Rebollo Sánchez Jorge 
Published: October 2019

En este artículo de investigación se presenta el proyecto de una plataforma interna de inglés por niveles, alojada en una suite interna de WordPress, como una estrategia remedial de tutoría especializada para nivelar a alumnos cuyo dominio del inglés es muy limitado en normales públicas, a sabiendas que la especialidad en inglés demanda un nivel B2 al cuarto año de carrera, meta poco alcanzable considerando la cantidad de horas asignadas de estudio y práctica del idioma.
Hoy, el estudiante mexicano normalista se ha de apropiar del inglés como lengua extranjera por medio de cursos curriculares establecidos en el plan de estudios 2018, dentro de un trayecto formativo de lengua adicional, con una inversión de seis horas semanales. Aun así, no se garantiza ni la calidad ni la eficiencia ni el adecuado y objetivo nivel del egresado frente a los retos, reales, de un mundo actual sin maquillaje. ¿Qué hacer? ¿Qué se propone como estrategia de enseñanza para asegurar el éxito del plan de estudios 1999? La respuesta operativa, diseñada y puesta en marcha, se presenta en esta investigación. Dicha propuesta se piloteó con dos generaciones de la Escuela Normal de Atlacomulco, Español, Historia e Inglés, en el uso de la Learning Management System (LMS) o plataforma de aprendizaje, desde su ingreso, permanencia y egreso, apoyados de recursos alternos de autoría propia, y de talleres alternos de práctica del inglés a contraturno.
PENURUNAN PRESTASI BELAJAR REMAJA PADA KELUARGA TKW DI DESA JUNTINYUAT INDRAMAYU
Authors: Suharto Meiliani Puji , Humaedi Sahadi 
Published: October 2019

Pengiriman Tenaga Kerja Indonesia ke luar negeri terus mengalami peningkatan guna meningkatkan perekonomian. Kabupaten Indramayu merupakah kabupaten pengirim TKI terbanyak di Indonesia. Saat ini para TKI tidak hanya pria saja, namun wanita pun turut berpartisipasi menjadi Tenaga Kerja Wanita (TKW) guna meningkatkan perekonomian keluarga. Ibu yang bekerja sebagai Tenaga Kerja Wanita (TKW) membawa berbagai dampak baik positif maupun negatif, tidak terkecuali bagi keluarga yang ditinggalkan terutama anak yang sudah memasuki usia remaja. Masa remaja sering dianggap sebagai masa yang paling rawan dalam proses kehidupan. Dalam keluarga TKW, ada beberapa fungsi keluarga yang berjalan secara tidak baik, sehingga membuat remaja lebih memilih lingkungan diluar keluarganya yang dapat menyebabkan penurunan pada prestasi belajar anak. Subjek penelitian adalah remaja usia 12 – 18 tahun yang berlatar belakang dari keluarga TKW dan memiliki permasalahan pada penurunan prestasi belajar di Desa Juntinyuat Indramayu. Tujuan dari penelitian adalah untuk mendeskripsikan kehidupan remaja dalam keluarga TKW dan faktor penyebab penurunan prestasi belajar remaja.
The genes regulating maintenance of cellular protein location are differentially expressed in porcine epithelial oviductal cells during longterm in vitro cultivation
Authors: Stefańska Katarzyna , Kocherova Ievgenia , Knap Sandra , Kulus Magdalena , Celichowski Piotr , Jeseta Michal 
Published: October 2019

Abstract
The oviduct is a part of female reproductive tract that is essential for successful fertilization and early embryo development. It is lined with epithelium consisting of two types of cells: ciliated and secretory. The primary function of ciliated oviductal epithelial cells (OECs) is to support the transport of gametes and embryos through the ovary, whereas secretory OECs produce components of the oviductal fluid. Undoubtedly, the oviductal epithelium plays a major part in the early aspects of pregnancy development, from providing an optimal environment for gametes and embryos to supporting fertilization. Therefore, our aim was to gain a better insight into the genetic changes underlying function of these cells. We have harvested OECs from crossbred gilts (n=45), at the age of about nine months and which displayed two regular estrous cycles, and established long-term primary culture of porcine OECs. Microarray analysis was utilized to determine differentially expressed genes during day 1, 7, 15 and 30 of cultivation, with our results revealing54 differentially expressed genes belonging to three ontology groups: „maintenance of location”, „maintenance of protein location” and „maintenance of protein location in cell”. Since the biochemistry and morphology of epithelial cells may change during long term cultivation, we conclude that our results are a reflection of these changes and help to shed a light on porcine OECs properties in in vitro environment.

Running title: Maintenance of cellular protein location in porcine epithelial oviductal cells
Dampak Pendidikan Terhadap Produktivitas dan Upah: Bukti Empiris Pasar Monopsoni di Industri Manufaktur Indonesia
Authors: Sukirno Nurachma Indrati , Damayanti Arie 
Published: October 2019

Teori Human Capital mengatakan bahwa tenaga kerja yang berpendidikan lebih tinggi akan mendapatkan upah yang lebih besar karena mereka memiliki produktivitas yang lebih tinggi. Namun bukti empiris menunjukkan peningkatan produktivitas tidak selalu diikuti oleh peningkatan upah. Hal tersebut menggambarkan adanya degree of monopsony yang dimiliki perusahaan kepada tenaga kerjanya. Penelitian ini meneliti adanya degree of monopsony yang berbeda antar sektor dengan cara melihat hubungan antara komposisi tenaga kerja berdasarkan level pendidikan terhadap productivity-pay gap/rent sharing yang didapatkan oleh industri manufaktur Indonesia pada kurun waktu 1996 dan 2006. Pengukuran rent sharing yaitu selisih antara produktivitas tenaga kerja dengan rata-rata pengeluaran upah tenaga kerja yang dibayarkan oleh perusahaan. Penelitian ini menggunakan pooled cross section data yang dikontrol dengan dummy tahun, dan diestimasi menggunakan metode Ordinary Least Square (OLS). Hasilnya menunjukkan bahwa sebagian sektor industri manufaktur memiliki degree of monopsony terhadap tenaga kerja yang berpendidikan menengah dan tinggi, ditunjukkan dengan rent sharing positif yang didapatkan perusahaan jika menggantikan tenaga kerja yang berpendidikan rendah dengan tenaga kerja yang berpendidikan menengah dan tinggi. Semakin tinggi level teknologi produksi suatu sektor maka semakin besar degree of monopsony sektor tersebut terhadap tenaga kerja yang berpendidikan tinggi.