bluuebunny/crossref_metadata_2025_split huggingface dataset:
The transcription factor basal regulatory network of Homo sapiens and Saccharomyces cerevisiae: uncovering the relationship between topology and phenotype
Authors: Hernández-Domínguez JL , Brass A. , Navarro-López EM 
Published: June 2019

AbstractTranscription factors play a key role in controlling which proteins are made by a cell. As transcription factors are themselves proteins, they are part of a complex interconnected and self-regulated network. We define the transcription factor basal regulatory network (TFBRN) as the network formed by the interactions between transcription factors (TFs) as proteins acting on target genes which are themselves TFs. The question then becomes as to whether topological features of this network are important in determining phenotypes caused by perturbations in TFs. To explore this, we developed two simple TFBRN models; one based on data from human TFs, and the other on the budding yeast. Even from this basic model we did find some very clear correlations between local topological measures and phenotypes seen in cancer and rare genetic diseases. This strongly suggests that the local network architecture of the TFBRN provides important information around the roles of transcription factors and the impacts to an organisation of their perturbation.Author SummaryThe human body is controlled by proteins whose production is coordinated by proteins known as transcription factors. These transcription factors can control multiple proteins, including other transcription factors. Does this network itself play any role in determining the properties of the transcription factors and their roles in cancer and disease? In this paper we find that there is a relationship between the local structures in the network and processes such as cancer and rare genetic diseases. We also found a similar relationship between local network characteristics and budding yeast phenotypes. This work therefore shows that simple properties of the network of interactions between transcription factors and their targets can be useful in determining the effects caused by changes in transcription factors (whether through deletion or allelic variation).
Influences of career establishment strategies on generation Y’s self-directedness career
Authors: Wong Siew Chin , Mohd Rasdi Roziah 
Published: June 2019

Purpose
The purpose of this paper is to examine the influence of generation Y’s career establishment strategies on self-directedness career and to determine the moderation effect of gender on the relationship.

Design/methodology/approach
Data were collected from 188 full-time employees from different functional areas and departments of selected MNCs in Malaysian Electrical and Electronic Industry. Partial least squares structural equation modeling was used to examine the influences of establishment strategies and the moderating role of gender on self-directedness career.

Findings
Findings show that there are significant positive relationship between career strategies and self-directedness career at career establishment stages of generation Y. There is a significant difference between males and females in career establishment strategy (i.e. creating career opportunities) and self-directedness career.

Research limitations/implications
This paper explains self-directedness career based on the review of related career literatures whereby some may not specifically referring to Generation Y.

Practical implications
Such insights are useful for HRD practitioners dto develop relevant HRD interventions to assist individuals and organizations in career development.

Originality/value
This paper offers new insight into the predictors of self-directedness career and the moderating role of gender on the relationships.
The role of learning management in agile management for consensus culture
Authors: Tokel Aytac , Dagli Gokmen , Altinay Zehra , Altinay Fahriye 
Published: June 2019

Purpose
The purpose of this paper is to evaluate the formation of a consensual culture of agile management used in schools where school administrators and teachers work.

Design/methodology/approach
This research is based on a qualitative research approach that highlights social phenomena and explores the environment in which they belong. In this context, five managers and seven teachers working in six vocational education institutions were asked semi-structured questions during face-to-face interviews.

Findings
The research revealed that technology has a great impact on foster learning management and the development of school culture based on consensus.

Research limitations/implications
The data of the research is limited to the participants who are Five managers and seven teachers working in six vocational education institutions within Nicosia context.

Practical implications
The school gained awareness on the uses of technology for learning and development.

Social implications
Merits of technology for consensus culture were examined in this paper.

Originality/value
The paper is original in that it gives insights for the education system on the technology and learning.
The association between nurses’ religiousness and job satisfaction
Authors: Mensah Henry Kofi , Asiamah Nestor , Azinga Samuel Awuni 
Published: June 2019

Purpose
This study aims to assess the effect of religiosity on the job satisfaction of nurses in response to the paucity of studies that have investigated this relationship in a health care setting. The authors also tested the moderation impact of materialism on the religiosity–satisfaction nexus.

Design/methodology/approach
The quantitative (correlational) research technique was applied to test hypotheses of interest. The simple random sampling method was used to select a representative sample of 458 nurses. Confirmatory factor analysis (CFA) was used to examine the factor structures of relevant constructs and to test hypotheses. The study’s ultimate CFA model produced a good fit at 5 per cent significance level [Chi-square (χ2) = 19.121; p = 0.454].

Findings
Religiosity was found to make a positive effect on job satisfaction and a negative effect on materialism. Materialism makes a negative effect on job satisfaction. Religiosity and materialism makes a significant negative interaction effect on nurses’ satisfaction after controlling for job income.

Practical implications
It is therefore concluded that religiosity is a positive behaviour that contributes to the satisfaction of nurses, but materialism must be avoided or at least reduced to maximise this impact.

Originality/value
In this study, the authors demonstrate that the positive effect of religiousness on job satisfaction can be negatively moderated by materialism so that religiousness makes less impact on satisfaction owing to the negative influence of materialism on job satisfaction.
Multi-scale surface patterning – an approach to control friction and lubricant migration in lubricated systems
Authors: Grützmacher Philipp G. , Rosenkranz Andreas , Szurdak Adam , Grüber Markus , Gachot Carsten , Hirt Gerhard , Mücklich Frank 
Published: June 2019

Purpose
The paper aims to investigate the possibilities to control friction in lubricated systems by surface patterning, making use of a multi-scale approach. Surface patterns inside the tribological contact zone tend to directly reduce friction, whereas surface patterns located in the close proximity of the contact area can improve the tribological performance by avoiding lubricant starvation and migration. Finally, optimized surface patterns were identified by preliminary laboratory tests and transferred to a journal bearing, thus testing them under more realistic conditions.

Design/methodology/approach
Surface patterns on a large scale (depth > 10 µm) were fabricated by micro- and roller-coining, whereas surface patterns on a small scale (depth < 2 µm) were produced by direct laser interference patterning. The combination of both techniques resulted in multi-scale surface patterns. Tribologically beneficial surface patterns (verified in ball-on-disk laboratory tests) were transferred onto a journal bearing’s shaft and tested on a special test-rig. To characterize the lubricant spreading behavior, a new test-rig was designed, which allowed for the study of the lubricant’s motion on patterned surfaces under the influence of a precisely controlled temperature gradient.

Findings
All tested patterns accounted for a pronounced friction reduction and/or an increase in oil film lifetime. The results from the preliminary laboratory tests matched well, with results from the journal bearing test-rig, both tests showing a maximum friction reduction by a factor of 3-4. Numerical investigations, as well as experiments, have shown the possibility to actively guide lubricant over patterned surfaces. Smaller periodicities, as well as greater structural depths and widths, led to a more pronounced anisotropic spreading and/or greater spreading velocities. Multi-scale surfaces demonstrated the strongest effects regarding the lubricant’s spreading behavior.

Originality/value
Friction, as well as lubricant migration, can be successfully controlled by using micro-coined, laser-patterned and/or multi-scale surfaces. To the best of the authors’ knowledge, the study demonstrates for the first time the unique possibility to transfer results obtained in laboratory tests to a real machine component.
Disease risk and its moderating effect on the e-consultation market offline and online signals
Authors: Li Jia , Tang Jie , Yen David C. , Liu Xuan 
Published: June 2019

PurposeThe purpose of this paper is to investigate the moderating effect of disease risk in terms of the major signals (i.e. status, reputation and self-representation) on the e-consultation platforms.Design/methodology/approachIn this study, the proposed research hypotheses are tested using the transaction data collected from xywy.com (in Need of Therapy). In fact, xywy.com is one the leading e-consultation service websites in China that provides a platform for the interactions between the physicians and patients (Yu et al., 2016; Peng et al., 2015). Generally speaking, it has all the needed design elements and in other words, a standard e-consultation website should have such items/components as physician homepage, physician review, free consultation, paid consultation and recommendation systems.FindingsThe obtained results reveal that all attributes including status, reputation and self-representation have a positive impact on physician’s online order volume. Moreover, there is a positive moderating effect of disease risk onto the online reputation, indicating a higher effect exists for the diseases with high risk. However, the effect of offline status and online self-representation is not moderated by the disease risk, indicating market signals (online reputation) may have a stronger predictive power than seller signals (offline status and online self- representation), and therefore market signals are more effective when/if the disease risk is high.Originality/valueE-consultation has gradually become a significant trend to provide the healthcare services, in the emerging economy such as China because of shortage of medical resources but having an adequate access in internet usage. The impacts of signals on the health care market have been validated by previous studies. However, the research focusing on the moderating effect of signaling environment in the health care industry is still lacking. As a result, the value of this research helps to bridge the aforementioned research gap.
Organizational practices as antecedents of the information security management performance
Authors: Pérez-González Daniel , Preciado Sara Trigueros , Solana-Gonzalez Pedro 
Published: June 2019

PurposeThe purpose of this paper is to expand current knowledge about the security organizational practices and analyze its effects on the information security management performance.Design/methodology/approachBased on the literature review, the authors propose a research model together with hypotheses. The survey questionnaires were developed to collect data, which then validated the measurement model. The authors collected 111 responses from CEOs at manufacturing small- and medium-sized enterprises (SMEs) that had already implemented security policies. The hypothesized relationships were tested using the structural equation model approach with EQS 6.1 software.FindingsResults validate that information security knowledge sharing, information security education and information security visibility, as well as security organizational practices, have a positive effect on the information security management performance.Research limitations/implicationsThe consideration of organizational aspects of information security should be taken into account by academics, practitioners and policymakers in SMEs. Besides, the work helps validate novel constructs used in recent research (information security knowledge sharing and information security visibility).Practical implicationsThe authors extend previous works by analyzing how security organizational practices affect the performance of information security. The results suggest that an improved performance of information security in the industrial SMEs requires innovative practices to foster knowledge sharing among employees.Originality/valueThe literature recognizes the need to develop empirical research on information security focused on SMEs. Besides the need to identify organizational practices that improve information security, this paper empirically investigates SMEs’ organizational practices in the security of information and analyzes its effects on the performance of information security.
Extending the potential of Baumol’s entrepreneurial allocation theory
Authors: Aeeni Zeynab , Motavaseli Mahmoud , Sakhdari Kamal , Saeedikiya Mehrzad 
Published: June 2019

PurposeThe underlying assumptions of Baumol’s theory of entrepreneurial allocation limits its potential to answer some key questions related to the entrepreneurship allocation. Hence, this paper aims to highlight the inherent limits of Baumol’s theory and suggest a new approach for understanding the entrepreneur-institution relationship and their functions.Design/methodology/approachThis is a conceptual paper with a narrow focus on the literature.FindingsThe paper argues that Baumol’s adherence to neoclassic economics assumptions about entrepreneur and institution, such as entrepreneurs as rational choice taker with predetermined goals or institutions as exogenous, limits the potential of his theoretical framework to explain productive entrepreneurship in weak institutional settings. As such, underlying on Austrian economics assumptions about entrepreneur and his/her agency, this paper proposes a reconceptualization of productive entrepreneurship as an outcome of the interaction between entrepreneur and context.Practical implicationsGoing beyond Baumol’s main proposition of one-sided influence of institutions on entrepreneurship allocation, this research highlights the influence of individual factors and entrepreneurial action on choosing entrepreneurial paths by entrepreneurs. So, future policies to stimulate productive entrepreneurship should consider these factors and go beyond Baumol’s mere focus on institutional improvement.Originality/valueGoing beyond one-sided influence of institutions on entrepreneurship allocation, this paper suggests an interaction centric approach which considers the role of actors and institutions as the co-creator of each other in the social process and argues that any effort for explaining the entrepreneurship should consider the co-creative nature of the actors and institutions as well as the endogenous nature of institutions. The proposed approach will help expanding entrepreneurship literature through finding answers to some key under-examined questions in the promising research stream of entrepreneurship allocation.
Conversation Analysis (CA) as a tool for exploring interaction in an online video-conferencing based support service
Authors: Chatwin John , McEvoy Phil 
Published: June 2019

PurposeAround 60 per cent of people with dementia in the UK live at home. The experience of caring for a family member with dementia can be rewarding and positive, but it can also be significantly stressful. Current healthcare policy is encouraging greater provision to support family carers. Along with respite-care, day-care and support group-based initiatives, there has also been a focus on developing dementia-specific communication training. The paper discusses this issue.Design/methodology/approachThe authors outline a new initiative “Empowered Carers” which is being piloted in the North of England. Empowered Carers is an online support and communication training service for family carers who are caring for someone with dementia at home. It utilises online video conference-calling technology to connect carers with support workers, and also allows for simultaneous interactions involving other family members. A central tenet of the approach is a theoretically grounded support model, based on the concept of mentalisation.FindingsThe authors describe the background to Empowered Carers, and how a conventional evaluation strategy for the initiative is being used alongside a socio-linguistic approach (Conversation Analysis – CA). This aims to provide empirical evidence about how the assimilation of mentalisation is reflected in the structuring of speech patterns in carers during support sessions.Originality/valueThe authors explain the CA method, how it has been applied to similar talk-based therapeutic settings, and why its ability to explore sequential linguistic patterns across extremely large data-sets is particularly suited to studying interaction in emerging online arenas.
Exchange rate volatility and exports from India: a commodity-level panel data analysis
Authors: Sharma Chandan 
Published: June 2019

PurposeThis study aims to examine the relationship between exchange rate risk and export at commodity level for the Indian case.Design/methodology/approachThe monthly panel data used for analysis are at a disaggregated level, which cover around 100 products, encompassing all merchandize sectors for the period spanning from 2012:12 to 2017:11. To measure the exchange rate volatility, the authors use real as well as nominal exchange rate concepts and predict the volatility of exchange rate using the autoregressive conditional heteroscedastic-based model. They use pooled mean group, mean group and common correlated effects mean group estimator that is suitable for the objectives and data frequency.FindingsThe empirical analysis indicates both short- and long-term negative effects of exchange rate variations on exporting. Specifically, in the long run, real exchange rate as well as nominal exchange rate volatility has significant effects on export performance, yet, the effects of uncertainty of nominal exchange rate is much severe and intense. In the short run, it is the nominal exchange rate uncertainty that hurts exports from India. Nevertheless, the short-run effect is much lesser than the long-run, supporting the argument that the short-term exchange rate risk can be hedged, at least partially, through financial instruments; however, uncertainty of the long-term horizon cannot be hedged easily and cost-effectively.Practical implicationsReducing uncertainty and attaining stability in exchange rate and price level should be an important policy objective in developing countries such as India to achieve higher export growth, both in the short and long run.Originality/valueUnlike previous studies, this paper tests the relationship using micro-level data and uses advanced econometric techniques that are likely to provide more precise information regarding the association between exchange rate volatility and trade flows.
Can brands deviate from their brand aesthetic? Brand luxury status as a moderator
Authors: Seifert Christin , Cui Tianyu , Chattaraman Veena 
Published: June 2019

PurposeThe purpose of this paper is to examine the effect of brand design consistency (BDC) on consumers’ aesthetic judgment and purchase intention; and whether this effect of BDC is moderated by a brand’s luxury status.Design/methodology/approachA mixed-factorial experimental design that manipulated the BDC of handbags (prototypical/high/low) and brand luxury status (luxury/non-luxury) was conducted among 311 female participants to test the proposed hypotheses.FindingsResults obtained fromt-tests and repeated measures ANCOVA demonstrate that prototypical brand designs, followed by high, and then low BDC products, evoked the most positive consumer responses. Additionally, brand luxury status moderated the effect of BDC on consumer response, such that the effect was more salient for non-luxury than luxury brands.Practical implicationsLuxury brands are able to leverage the halo effect, as perceived brand design inconsistency has a lesser impact on consumers’ purchase intentions than for non-luxury brands. Non-luxury brands have less latitude to deviate from their brand aesthetic, and maintaining BDC in new products is imperative for these brands.Originality/valueDesigners constantly navigate the thresholds of their brand’s aesthetic in design decisions; however, few studies have investigated consumer responses to deviations from brand aesthetics. To the authors’ knowledge, no studies have examined this phenomenon in relation to a brand’s luxury status, a factor that critically impacts consumers’ design expectations.
Impact of training and professional development on health management and leadership competence
Authors: Ayeleke Reuben Olugbenga , North Nicola Henri , Dunham Annette , Wallis Katharine Ann 
Published: June 2019

Purpose
Training to improve health management and leadership competence is recommended. However, there is limited evidence showing the impact of training on competence. The purpose of this paper is to evaluate the evidence for the impact of training and professional development on health management and leadership competence.

Design/methodology/approach
A systematic review was conducted using a mixed-methods design. Studies using qualitative, quantitative or mixed-methods design were included. The following electronic databases were searched to October 2018: CENTRAL, CINAHL, EMBASE, ERIC, NEDLINE and PsycINFO. Study eligibility and methodological quality were assessed independently by two review authors. Data from qualitative studies were synthesised using thematic analysis. For quantitative studies, odds ratio (OR) or mean difference (MD) and 95% confidence interval (CI) were calculated for each intervention. Where appropriate, qualitative and quantitative data were integrated into a single synthesis using Bayesian methods.

Findings
In total, 19 studies were identified for inclusion in the review. Training and professional development interventions using flexible, multiple training techniques tailored to organisational contexts can improve individual competence and performance. Such training is typified by a leadership development programme. There was insufficient evidence to determine the effects of interventions on organisational performance.

Originality/value
This is the first systematic review evaluating the impact of training and professional development interventions on health management and leadership competence.