bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparative Analysis of Pelvic/Sacral versus Vertebral Chordomas in the US from 2000 to 2020
Authors: Agner Kevin E. , Larkins Michael C. 
Published: October 2024

Abstract

Purpose
Chordomas are rare tumors of the axial skeleton, with 55% of cases affecting the pelvis/sacrum and 10% affecting the vertebrae of the spine. We seek to provide a comparative analysis of demographic, disease, and treatment variables between these two disease sites.
Methods
Patients with chordomas were identified via the Surveillance, Epidemiology, and End Results (SEER) Program. Inclusion criteria was malignant chordoma (ICD-O-3 codes 9370/3-9372/3) limited to the pelvis, sacrum, or vertebrae of the spine (PSV). Fisher’s Exact and Kaplan-Meier survival analysis was conducted to assess variation between PSV disease sites.
Results
Eight-hundred-ninety-six patients diagnosed with chordomas of the PSV were identified. Patients with pelvic/sacral chordomas were more likely to be older (p < 0.001), non-White (p < 0.001), come from urban counties (p = 0.042), and have more advanced disease (p < 0.001) compared to those with vertebral chordomas. Patients with pelvic/sacral chordomas were also less likely to undergo radiotherapy (p < 0.001) but were more likely to undergo gross total resection (p < 0.001). Five-year overall survival (5y OS) for those with pelvic/sacral chordomas was 72.0% survival [66.8%,77.2%] compared to 71.0% [66.6%,75.4%] for those with vertebral chordomas. Disease histology was associated with variation in 5y OS (p < 0.001); treatment with surgery was associated with increased 5y OS (p < 0.001 for both disease sites).
Conclusion
Significant differences in both distribution and five-year overall survival were seen among patients with chordomas when comparison was conducted with respect to pelvic/sacral versus vertebral disease sites. Further investigation into the impact of disease histology and treatment modalities is warranted.
Percutaneous Vascular Plug in Management of an Acquired Broncho Pleural Cutaneous Fistula
Authors: Alex Ajay , Praveen A , George Niwin , Vinu C V , B Radhika Devi , Jose Neetha 
Published: October 2024

Abstract

Background:
Bronchopleural fistula (BPF) / broncho pleural cutaneous fistula is an abnormal communication between the peripheral bronchial tree and pleural space which can further also open to the skin surface. It is associated with significant morbidity and mortality in addition to poor quality of life. Management requires a multidisciplinary approach with careful evaluation to choose the best approach to treatment.
Case Presentation:
A 36-year-old male presented with a left chest wall tumor with multiple surgeries and CT revealing a left apico-posterior segment broncho pleural cutaneous fistula. Various options for the management of the BPCF including surgery and bronchoscopic occlusion were considered however an IR approach was planned. Plan was for vascular plug occlusion with/without glue embolization of the apico-posterior segmental bronchus. A 6F sheath was placed under direct vision and a 12 mm CERA plug was deployed. After plain plug occlusion, there were no signs of air leak. Various options for management including surgery and bronchoscopy procedures are limited in patients with poor pulmonary reserve. The IR approach offers the advantage of doing the procedure under real-time fluoroscopy, and no airway compromise. However, literature describes the use of glue to seal the interstices of the device which if not sealed was a cause of recurrence later. In our case, we report the percutaneous use of a CERA vascular plug as the sole device, especially since it has a polytetrafluoroethylene (PTFE) membrane which ensures occlusion, in addition to its titanium nitride coating which improves epithelialization. This ensures sustained occlusion as the sole agent, unlike other devices including the Amplatzer vascular plug.
Conclusions:
This highlights the relatively easy percutaneous route and the first report of CERA vascular plug usage for managing a case of broncho pleural cutaneous fistula.
EIF2S2 as a Prognostic Marker and Therapeutic Target in Glioblastoma: Insights into its Role and Downstream Mechanisms
Authors: Fan Bo , Pan Qing , Yuan Xiaokai , Du Wei , Yan Zhongjie 
Published: October 2024

Abstract

Glioblastoma (GBM) the most common and most aggressive primary brain tumor has a five-year survival rate of less than 5%. The onset of GBM is very complicated and has always been the focus of researchers. This study analyzed data from 155 GBM and 5 normal tissues from The Cancer Genome Atlas (TCGA), and patients were categorized into high and low EIF2S2 expression groups. The Overall survival and disease-free survival of GBM patients in low expression of EIF2S2 group were significantly higher than those in high expression of EIF2S2 group (p < 0.001), and the expression level of EIF2S2 was significantly correlated with tumor grade (p < 0.001) and tumor recurrence (p < 0.001). The study designed three different short hairpin RNA (shRNA) sequence vectors, identifying shEIF2S2-1 as the most effective. This vector significantly reduced EIF2S2 expression, cell proliferation, and migration while increasing apoptosis in SHG-44 and U251 cells (p < 0.01). By detecting SHG-44 cells infected with shEIF2S2 vector and shCtrl with human whole gene expression chip, we identified WNT5A that is a downstream target gene of EIF2S2. Interfering with WNT5A and overexpressing EIF2S2 in SHG-44 and U251 cells revealed that EIF2S2 regulates WNT5A expression. This regulation led to an increased apoptosis rate (p < 0.05) and a significant reduction in cell migration (p < 0.05) in both the EIF2S2 overexpression and shWNT5A interference groups, confirming that WNT5A is a downstream regulatory target of EIF2S2. This study revealed the key role of EIF2S2 in GBM and its potential molecular mechanism.
Peptide Derived from Bungarus caeruleus Proteome Binds with Higher Affinity to Ethionamide Resistance Regulator of Mycobacterium tuberculosis than Isoniazid
Authors: Singh Priyanka , Jayaraman Gurunathan 
Published: October 2024

Abstract

Antimicrobial resistance has become a serious health concern worldwide because of high morbidity and mortality. An increase in multi-drug and extensively drug-resistant (MDR and XDR) strains of Mycobacterium tuberculosis has trigged the finding of effective therapeutic alternatives. A computational approach has been utilized to predict and prediction of novel antimycobacterial peptides using the proteome sequences of Bungarus caeruleus (Indian Krait). In-silico digestion of proteome sequences using five different enzymes yielded more than 1000 shorter peptides sequences. Further, the antibacterial peptide was predicted using DBAASP server. Based on the various physiochemical properties (including stability, half-life and ADMET) 11 peptides were taken for molecular docking study. Ethionamide resistance regulator (EthR)-peptide docking was performed using HADDOCK server, and the peptide sequence HGATVAVKQVNRCSKNHL shows the maximum binding affinity with EthR. The binding score was found to be maximum for the peptide with -9.3 kcal/mol in comparison with the standard drug (Isoniazid) with -5.69 kcal/mol when analysed with PRODIGY server. The complex structure and the interactions were found to be stable during the 100 ns molecular dynamics simulations using Gromacs-2023.1. The stability of the complex was analysed in terms of RMSD, RMSF, radius of gyration, H-bond, and SASA. MMPBSA analysis indicated that the free energy of interaction of EthR with peptide and Isoniazid was found to be -36.15 kcal/mol and -6.95 kcal/mol respectively. The results indicate the potential anti-mycobacterial property of this 18-mer peptide which can be validated further through in-vitro and in-vivo studies.
Development and Validation of the Chinese Insulin Medication Literacy Scale (Ch-InMLS) for Patients with Diabetes Mellitus
Authors: Si fangying , Feng Tao , Shi xiangfen , Chen sufang , Yang yongjie 
Published: October 2024

Abstract

Objective: The aim of this study was to develop a simplified insulin medication literacy scale for patients with diabetes mellitus and evaluate its psychometric properties.
Methods: We developed an initial scale based on the framework of knowledge-attitude-practice model (KAP) with skills added, and the items were developed from literature review and insulin related guidelines, semi-structured interviews, cognitive interviews. After two rounds of expert consultation and pilot survey, a final version of the scale was developed. A cross-sectional survey was conducted with 553 patients with diabetes mellitus in Zhengzhou for the psychometric evaluation. In the construct validity, the number of participants was 262 for exploratory factor analysis and 291 for confirmatory factor analysis. In the reliability, internal consistency reliability and split-half reliability were evaluated using Cronbach’s alpha coefficients.
Results: The final scale consists of 36 items with 4 dimensions, including knowledge, attitude, practice, skill. EFA suggested four factors explaining 67.556% of the total variance (Kaiser–Meyer-Olkin test = 0.944, Bartlett’s test χ2 = 7384.296, P < 0.001). The results of confirmatory factor analysis showed that the model fit the data adequately. The Cronbach’s a coefficient was 0.849 for the overall scale and ranged from 0.744 to 0.783 for domains. The Spearman-Brown split-half reliability coefficient was 0.893 for the total scale and ranged from 0.793 to 0.872 for domains. The test-retest reliability coefficient of the total scale was 0.968 and ranged from 0.880 to 0.959 for domains.
Conclusions: The scale has acceptable content validity, construct validity, and good reliability. It can be used to evaluate the level of insulin medication literacy of patients with diabetes mellitus in China.
Systematic Review and Meta-Analyses of Mental Health App RCTs: Persuasive Design, Engagement, and Efficacy
Authors: Valentine Lee , Hinton Jordan D. X. , Bajaj Kriti , Boyd Larissa , O’Sullivan Shaunagh , Sorenson Rory P. , Bell Imogen , Vega Miguel Sobredo , Liu Virginia , Peters Wilma , Mangelsdorf Shaminka , Wren Thomas , Moller Carl , Cross Shane , McEnery Carla , Bendall Sarah , Nicholas Jennifer , Alvarez-Jimenez Mario 
Published: October 2024

Abstract

This systematic review and meta-analysis examined the efficacy of digital mental health apps and the impact of persuasive design principles on engagement and clinical outcomes. Of 119 eligible randomised controlled trials, 92 studies (n=16,728) were included in the analysis. Results demonstrated that mental health apps significantly improved clinical outcomes compared to control groups (g = 0.43). Apps used between 1 and 12 persuasive design principles (mode = 5). Notably, only 76% of studies reported engagement data. Twenty-five engagement metrics were identified across studies and grouped into 10 categories. Meta-regression and correlation analyses found no significant association between persuasive design principles and app efficacy or engagement. Future research should prioritise standardising and documenting engagement metrics and persuasive design principles; differentiating between engagement with mental health apps and real-world behavioural change and exploring the integration of persuasive design with behaviour change models to more accurately assess their influence on engagement and outcomes.
Data mining study on adverse events of cinacalcet based on JADER database
Authors: Tan Feilong , Xia Hongying , Yin Wenjie 
Published: October 2024

Abstract

Background
Cinacalcet is the first calcium-sensing receptor agonist (calcimimetic) primarily indicated for the management of secondary hyperparathyroidism in patients with chronic kidney disease. This study aims to evaluate the safety profile of cinacalcet in real-world clinical settings.
Methods
Data on adverse events (AEs) associated with cinacalcet, reported from the second quarter of 2004 to the fourth quarter of 2023, were extracted from the Japanese Adverse Drug Event Report (JADER) database. Data mining was performed using the reporting odds ratio (ROR) method, and the time to onset was analyzed using the Weibull Shape Parameter (WSP).
Results
A total of 663 AE reports related to cinacalcet were identified, involving 284 Preferred Terms (PTs) and 24 System Organ Classes (SOCs). Six noteworthy SOCs qualified based on criteria. Additionally, 67 AEs were identified with positive signals, comprising 41 significant AEs and 36 unexpected AEs. Notable signals that warrant particular attention include parathyroid haemorrhage, electrocardiogram QT shortened, sphincter of Oddi dysfunction, nephrolithiasis, intestinal obstruction, pancreatitis, ascites, gastrointestinal necrosis. The majority of AEs occurred within the first month of treatment. The WSP was calculated to be 0.66, indicating an early failure type.
Conclusion
This study has identified several significant and unexpected AEs associated with cinacalcet use, highlighting the need for careful monitoring, especially during the early stages of therapy.
REMINDER program: a randomized controlled trial protocol of a neuropsychological intervention for lifestyle modification in older adults at risk of dementia
Authors: Silva Ana Rita , Baptista Catarina , Baldeiras Inês , Pinho Maria Salomé , Lima Margarida , Afonso Rosa Marina 
Published: October 2024

Abstract

Background
Most dementia risk reduction trials encompass interventions mostly focused in cognitive and health monitoring risk factors, with less focus is given to psychosocial risk factors (e.g. social isolation, depression, anxiety) which can contribute to impoverished engagement in brain protective lifestyles. The REMINDER program was designed to increase at-risk older adults’ competence in terms of cognitive reserve, socialization and emotion regulation skills and goal setting/goal-monitoring; within the framework of the dementia prevention available guidelines.
Aims
This manuscript aim is to present the protocol for two randomized controlled trials for the validation of the REMINDER program.
Methods
The REMINDER study will a Community Trial (cognitively unimpaired older adults at risk; N = 270) and a Clinical Trial (individuals with Mild Cognitive Impairment; N = 270). The Clinical Trial will include an additional harm that combines caregivers’ education and support with the REMINDER program. Participants will take part of the REMINDER program for 20 sessions and complete pre/post and follow-up outcome assessment measures. This neuropsychologist-led group program include education, experiential/reflective and practice moments, including behavior modification techniques throughout the modules. Primary outcomes will be a cognitive function and healthy lifestyle behavior. Secondary outcomes include performance in specific cognitive functions, functional status, psychosocial/mental health indicators and blood-based markers of neurodegeneration.
Conclusions
Part of the World-Wide FINGERS network, the REMINDER program aims to contribute with the inclusion of goal monitoring, emotion regulation techniques, peer support and other behavioral techniques in a dementia prevention trial, fostering engagement and long-term adherence to protective lifestyles across the dementia risk continuum.
Trial registration
ClinicalTrial.gov Identifier NCT05296980
Clinical Relevance and Applicability of the 2022 World Health Organization Classification of Childhood B Lymphoblastic Leukemia in the Context of MRD-Directed Therapy
Authors: Patkar Nikhil , Rajpal Sweta , Chatterjee Gaurav , Bhanshe Prasanna , Terse Vishram , Joshi Swapnali , Chaudhary Shruti , Shetty Dhanlaxmi , Mohanty Purvi , Dhamne Chetan , Tembhare Prashant , Sriniva Shyam , Chichra Akanksha , Moulik Nirmalya Roy , Banavali Shripad , Gujral Sumeet , Narula Gaurav , Subramanian Papagudi 
Published: October 2024

Abstract

WHO5-2022 classification of B-lymphoblastic leukemia (B-ALL) incorporates several novel entities requiring high-throughput sequencing for their accurate characterization. The clinical relevance of this classification in the context of contemporary MRD-directed therapy is unclear. We analyzed 533 pediatric B-ALL uniformly treated with ICiCLe-ALL-14 protocol as defined by WHO2016 and reclassified them as per WHO5-2022 using targeted sequencing, FISH, and cytogenetics. Subtype-defining genetic abnormalities were identified in 81.2% of the cohort as per the WHO5 classification. Among the new subtypes, PAX5alt, MEF2D-r, and BCR::ABL1-like(ABL-class) were associated with an inferior 2-year event-free survival (EFS) of 39.1% (p < 0.0001), 53.8% (p = 0.024) and 60.6% (p = 0.043), respectively. We developed a 3-tier genetic risk stratification model incorporating 15 genetic subtypes and the IKZF1 deletion. Children with standard, intermediate, and high genetic risk demonstrated 2-year EFS of 92.6%, 71.0%, and 50.7% (p < 0.0001), and 2-year overall survival of 94.3%, 81.9%, and 71.6% (p < 0.0001), respectively. Genetic risk further identified heterogeneous outcomes among ICiCLe risk groups (p < 0.0001). Standard genetic risk was associated with superior OS and EFS irrespective of MRD status. We demonstrate the applicability of the WHO5 classification in routine practice and create a general framework for incorporating the WHO5 classification in risk-adapted therapy for childhood B-ALL.
An inorganic “non-targeted” characterization platform for comprehensive monitoring of elements in surface water
Authors: Tirez Kristof , Dehaspe Joni , Stappen Jeroen Van , Joris Ingeborg , Vanhoof Christine , Voorspoels Stefan , Annys Johan 
Published: October 2024

Abstract

Background
The concept of bioavailability influencing environmental risk from metals has gained European regulatory and scientific support, but routine implementation remains a challenge due to the scarcity of physico-chemical data obtained from national surface water monitoring networks for assessing metal complexation with abiotic ligands. It is essential to remain vigilant and to ensure that the narrow focus of our routine analytical equipment does not limit our perspective. The focus blinders in our surface water monitoring networks should not transform into vision blinders, preventing us from considering broader insights and possibilities. Thanks to advancements in analytical instrumentation and data processing capabilities, this study presents an inorganic “non-targeted” characterization platform for wide-eyed and high-quality surface water monitoring that is both time-efficient and cost-effective.
Results
This study evaluated the feasibility of a comprehensive inorganic quantitative non-target analysis combined with geochemical modeling as holistic monitoring, i.e., a complete and comprehensive characterization of matrix and trace elements in Flemish surface water samples. For this purpose, state-of-the-art inductively coupled plasma-tandem mass spectrometry (ICP-MS/MS) and Discrete Analyzer instrumentation were employed to perform quantitative analysis of (nearly) all elements in the periodic table. The obtained quantitative analysis data served as input for the PHREEQC geochemical model to calculate the chemical species of the elements and estimate the concentration of the free metal ion. For elements contributing to standard exceedances in Flemish waterways (e.g. Co), holistic monitoring can enhance understanding of their "(biological) availability" and ecological impact relative to environmental quality standards derived from chronic ecotoxicity data (NOEC or EC10). Different approaches to study the bioavailability of metal/metalloid species in freshwaters are compared, including the implementation of biotic ligand model-based approaches in risk assessment frameworks.
Conclusion
examples of the added value of holistic monitoring, i.e. coupling of a non-target characterization platform with geochemical modeling, are given in terms of i) improved analysis quality on the entire sample and not limited to individual analytes, ii) Improved data interpretation, not only the dissolved concentration per element but the concentration for each element species, iii) Proactive policy on future contaminants: analysis data of elements that are currently not monitored on a routine basis.
Mid-term outcomes of moderate-severe cystocele repairing with autologous fascia lata harvested through a small incision
Authors: Yu Bo , Yang Junfang , Nie Qingyang , Zhang Kun , Han Jinsong , Wang Yiting 
Published: October 2024

Abstract

Introduction and Hypothesis:
To investigate the mid-term outcomes of transvaginal repair for moderate-severe cystocele using autologous fascia lata harvested through a single small incision.
Methods
Between February and October 2022, 35 patients with morderate to severe cystocele undergoing transvaginal repair with autologous fascia lata were included. Patient demographics and perioperative data were collected, with follow-ups through outpatient visits or phone calls. Patients were evaluated by subjective perception of vaginal bulging, physical examination, Pelvic Floor Distress Inventory (PFDI-20) Questionnaire, patient satisfaction, Patient Global Impression of Improvement (PGI-I) scores, regret rate, willingness to recommend, complications, and harvesting site issue.
Results
The patient’s mean age was 60.44 ± 6.01 years. Fascia lata harvesting took 32.92 ± 19.72 minutes, reconstruction surgery lasted 141.21 ± 37.89 minutes. Follow-up duration was 15.94 ± 2.46 months. 5.7% (2/35) of the patients reported a non-interfering vaginal bulge not requiring treatment. Objective recurrence rate was 4.26% (1/24, Aa or Ba>0) PFDI-20 was significantly improved (P < 0.0001). All 35 patients (100%) were highly satisfied, with PGI-I score very much improved or improved. No patient regretted. 97.14% (34/35) would recommend the procedure. One patient developed poor wound healing at the vaginal apex. One patient developed thromboembolic event. Harvest site: 2.86% (1/35) developed a non-bothersome thigh bulge, 17.14% (6/35) noted an impact on wound appearance, and 8.57% (3/35) reported mild paresthesia.
Conclusion
Autologous fascia lata for cystocele treatment shows promising mid-term outcomes, safely and effectively enhancing QoL with high satisfaction. Despite concerns about leg scarring, no patient regretted and would recommend the procedure. Long-term outcomes require larger follow-up studies.