bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Fused Deep Learning Approach to Transform Novel Drug Repositioning
Authors: Cao Dongsheng , Li Kun , Yi Jiacai , Ye Qing , Yang Xixi , Yu Long , Deng Youchao , Wu Chengkun , Hou Tingjun , Jiang Dejun 
Published: November 2024

Abstract

Drug repositioning holds significant promise for discovering new therapeutic applications of existing drugs, thereby accelerating drug development, reducing associated costs, and improving overall efficiency. However, current methodologies encounter difficulties in effectively managing diverse network representations, tackling cold start issues, and handling intrinsic attribute representations. In this study, we introduce UKEDR, a fused deep learning framework that seamlessly integrates knowledge graph embedding, sophisticated pre-training strategies, and recommendation systems to address these challenges in drug repositioning. In UKEDR, a straightforward yet effective semantic similarity-driven embedding approach that leverages both pre-trained embeddings and knowledge graph structure was proposed to overcome the intractable cold start issue. Our comprehensive evaluations reveal that UKEDR outperforms various state-of-the-art baselines, including classical machine learning, network-based and deep learning approaches. In a cold start scenario simulating real-world drug discovery, UKEDR achieves 24.2% higher AUPR compared to the latest state-of-the-art, highlighting its superior capability in handling unseen nodes and generalizing to novel compounds. Furthermore, we demonstrate the effectiveness of UKEDR through repurposing case studies for various diseases such as falciparum malaria, prostate cancer and so on. Finally, model interpretability is enhanced through knowledge graph visualization, providing valuable insights into the drug repositioning process.
A Novel Empowered System for ISL Gesture Recognition
Authors: Sharma Durgesh M. , Qureshi Shahana G. , Gianey Hemant Kumar , Bhutada Kunika , Khune Sahil , Pillai Vinaykumar , Selokar Kushagra , Singabhatti Siddhesh , Gehani Hitesh , Shandilya Shishir Kumar , Bhanuse Roshan 
Published: November 2024

Abstract

In India, a large population is of hearing-impaired and vocal disabled. To provide them equality in society and to reduce their isolation in society an Indian Sign Language (ISL) for gesture recognition is highly required. This paper introduces an improved novel empowered system for ISL gesture recognition which can recognize accurately live videos including finger word spelling, and single-handed static and dynamic gestures. In the proposed system, Artificial Intelligence (AI), and Machine Learning (ML) approaches are incorporated to promptly identify the acknowledge and interpret ISL gestures. It also removes the communication barriers and fostering inclusiveness to improve the accuracy of the proposed system. Additionally, to improve the accuracy the Convolutional Neural Networks (CNNs) approach is incorporated to extract hierarchical features from visual data, enabling precise and prompt sign language interpretation, and the Support Vector Machines (SVMs) approach is incorporated to optimize classification margins and handles high-dimensional data effectively. With a 91% accuracy rate for single-handed dynamic words and a 97% accuracy rate for finger spelling alphabets, the proposed method successfully detects both types of words. Experiment outcomes indicate that this method attains a higher recognition rate than various existing techniques.
Liver-related mortality in homeless-experienced adults over a 16-year period
Authors: Adams Logan , Dickins Kirsten , Lewis Elizabeth , Beiser Marguerite , Baggett Travis , Fine Danielle 
Published: November 2024

Abstract

Homeless-experienced adults have higher liver-related mortality than the general population. The objective of our study was to examine temporal liver-related mortality trends and assess cause-specific liver-related mortality disparities in a large cohort of homeless-experienced adults. We linked a cohort of 60,092 adults who received care at Boston Health Care for the Homeless Program (BHCHP) from 2003-2017 to Massachusetts death occurrence files spanning 2003-2018. We evaluated temporal trends in age-standardized liver-related mortality rates in comparison to the MA population. We identified the leading causes of liver-related death aggregated across the study period and compared these cause-specific mortality rates to the general population, reporting standardized mortality rate ratios (SRRs). Of the 7,130 deaths in the cohort, 652 (9.1%) were liver-related. Among liver-related decedents, the mean age at death was 55.7 years (SD 8.3); 517 (79.2%) were male and 399 (61.2%) were White. Liver-related mortality decreased on average 3.5% annually (95% CI: -6.6%, -0.3%), though remained significantly higher than the MA population throughout the study period. Leading causes of liver-related death were cirrhosis (n=157, SRR 3.2 [95% CI: 3.2, 3.3]), liver cancer (n=148, SRR 2.4 [95% CI: 2.4, 2.5]), alcohol-related liver disease (n=140, SRR 4.4 [95% CI: 4.3, 4.6]), and viral hepatitis (n=99, SRR 7.2 [95% CI: 6.9, 7.6]).Liver-related deaths are an important contributor to excess mortality among homeless-experienced adults. Efforts to reduce this disparity should address alcohol use disorder and viral hepatitis given their substantial contribution to the disparity of mortality in this population.
Wear behavior dominated by strain partitioning between retained austenite and α-Fe in bainitic steel
Authors: Chen Sida , Huang Qinyuan , Wu Fengshuai , Li Zulai , Shan Quan 
Published: November 2024

Abstract

The strains in α-Fe (bainite) and retained austenite (RA) exhibit an apparent discrepancy during deformation, namely strain partitioning, which can determine the tensile behavior of bainitic steels. Due to the involvement of plastic deformation and strain accumulation in the wear process, the strain partitioning phenomenon must be considered in the study of wear mechanisms. The impact wear tests results indicated that the wear behavior was strongly affected by strain partitioning between α-Fe and RA, and the initial hardness and work-hardening rate were not the main factors determining the wear resistance. The strain partitioning is closely related to the RA morphology tailored by isothermal processes, which was proved by in situ tensile test. The strain discrepancy between the continuous thin film RA and α-Fe was shown to be less significant. A smaller strain discrepancy alleviated stress concentration and minimized the occurrence of cracks and material spalling during wear. The strain discrepancy between blocky RA and α-Fe was shown to be greater. The high strain in blocky RA promoted the the strain induced transformation (SIT) effect and increased the work-hardening rate; however, it led to strain concentration on the worn surface and accelerated surface spalling.
Phototactic moth diversity (Lepidoptera: Heterocera) in Banaras Hindu University, Varanasi, Uttar Pradesh, India: A preliminary survey and checklist
Authors: Kumar Ram , Chaudhary Ram Ajeet , Arya Varun , Giri Gouri Shankar , Keval Ram , N Srinivasa , Raju SVS , Srivast Kartikeya 
Published: November 2024

Abstract

Survey activities were conducted over two years from 2022 to 2024 at the main campus of Banaras Hindu University (BHU), Varanasi, Uttar Pradesh, India to know and documented the species richness of moth’s diversity. The result of the survey activities results into collection, identification and documentation of a total of 112 months belongs to 89 genera of 9 families and 31 sub families. Members of the family Erebidae and Cramibidae shown dominance over other with 28 genera having 33 species and accounts for the 29.72 per cent of total moth diversity each. This was followed by Noctuidae (15.31 per cent: 17 species; 12 genera), Geometridae (12.61 per cent:14 species; 11 genera), Sphingidae (8.12 per cent:9 species; 5 genera) and others. The least species richness was observed in Eupteroidae, Nolidae, and Notodinidae which accounts for the 4.54 per cent of total moth diversity of the study area. Earlier studies that had been conducted during 2020 reported 99 month species belonging to 84 genera and 11 families. The current investigation documented 5 more genera but the number of families was reduced from 11 to 09. The activities compared the works that had been done earlier and aimed to find out the possible reasons for the increased or decreased in faunal diversity. Rapidly growing urbanisation, light and environmental pollution are some of the factors may be responsible for decline in moth diversity.
The Sustainability Performance of Maintenance 4.0 in The Indonesian Coal Mining Sector
Authors: Setyoko Ajun Tri , Saputra Bhetta Age , Kristiningrum Ellia , Nurcahyo Rahmat , Suryanegara Muhammad , Ali Imran 
Published: November 2024

Abstract

Coal mining in Indonesia plays a strategic role in meeting domestic and export energy needs. However, this increasing demand also brings sustainability challenges that require effective maintenance management, especially for heavy equipment such as dump trucks. Maintenance 4.0 is present as a digital technology-based maintenance solution, using the Internet of Things (IoT) to monitor the health condition of heavy equipment components. Maintenance 4.0 with IoT technology can also be used to predict future machine failures. This study aims to measure the sustainability performance of the implementation of maintenance 4.0 using Overall Sustainability Scores (OSS) at 15 coal mining locations in Indonesia, focusing on the use of dump trucks equipped with IoT technology. The results showed that overall sustainability scores in the coal mining sector was 0.712. The sustainability indicator with the highest value was cost reduction (spare parts and material costs) of 0.919. The sustainability indicator with the lowest value was overall efficiency (frequency of damage) of 0.615. These results indicate that the digital transformation towards maintenance 4.0 needs to be directed at the overall efficiency indicator. Increasing overall equipment efficiency by reducing the frequency of unexpected breakdowns can support sustainability goals by reducing the use of natural resources and extending the life of heavy equipment.
Confidence-Based Curricula for Multi-Agent Path Finding via Reinforcement Learning
Authors: Phan Thomy , Driscoll Joseph , Romberg Justin , Koenig Sven 
Published: November 2024

Abstract

A wide range of real-world applications can be formulated as Multi-Agent Path Finding (MAPF) problem, where the goal is to find collision-free paths for multiple agents with individual start and goal locations. State-of-the-art MAPF solvers are mainly centralized and depend on global information, which limits their scalability and flexibility regarding changes or new maps that would require expensive replanning. Multi-agent reinforcement learning (MARL) offers an alternative way of addressing MAPF problems by learning decentralized policies that can generalize over a variety of maps. While there exist some prior works that attempt to connect both areas, the proposed techniques are heavily engineered and very complex due to the integration of many mechanisms that limit generality and are expensive to use. We argue that much simpler and more general approaches are needed to bring the areas of MARL and MAPF closer together with significantly lower costs. In this paper, we propose Confidence-based Auto-Curriculum for Team Update Stability (CACTUS) as a lightweight MARL approach to MAPF. CACTUS defines a simple reverse curriculum scheme, where the goal of each agent is randomly placed within an allocation radius around the agent's start location. The allocation radius increases gradually as all agents improve, which is assessed by a confidence-based measure. In addition, we propose an extension called Confidence- and Conflict-Based Curriculum Learning with Allocation Radius Adaptation (C3LARA), using weighted sampling of goal locations to improve conflict resolution in scenarios of high agent density. We provide a theoretical analysis of the strengths and limitations of CACTUS regarding exploration efficiency and multi-agent coordination. We evaluate CACTUS and C3LARA in various maps of different sizes, obstacle densities, and numbers of agents. Our experiments demonstrate better performance and generalization capabilities than state-of-the-art MARL approaches with less than 600,000 trainable parameters, which is less than 5% of the neural network size of current MARL approaches to MAPF.
No evidence of immune exhaustion after repeated SARS-CoV-2 vaccination in vulnerable and healthy populations
Authors: Bowdish Dawn , Benoit Jenna , Breznik Jessica , Wu Ying , Kennedy Allison , Liu Li-Min , Cowbrough Braeden , Baker Barbara , Hagerman Megan , Andary Catherine , Mushtaha Maha , Abdalla Nora , Gauvreau Gail , Kim Paul , Denburg Judah , Costa Andrew , Leong Darryl , Nazy Ishac , Duong MyLinh , Bramson Jonathan , Larché Maggie , Verschoor Chris P. 
Published: November 2024

Abstract

Frequent SARS-CoV-2 vaccination in vulnerable populations has raised concerns that this may contribute to T cell exhaustion, which could negatively affect the quality of immune protection. Herein, we examined the impact of repeated SARS-CoV-2 vaccination on T cell phenotypic and functional exhaustion in frail older adults in long-term care, individuals on immunosuppressive drugs, and healthy adults. Spike-specific CD4+ and CD8+ T cell levels did not decline in any cohort following repeated SARS-CoV-2 vaccination, nor did the expression of exhaustion markers on spike-specific or total T cells increase. T cell production of multiple cytokines (i.e. polyfunctionality) in response to the spike protein of SARS-CoV-2 did not decline in any cohort following repeated vaccination. None of the cohorts displayed elevated levels of terminally differentiated T cells following multiple SARS-CoV-2 vaccinations. Thus, repeated SARS-CoV-2 vaccination was not associated with increased T cell exhaustion in older frail adults, immunosuppressed individuals, or healthy adults.
ОТ МАГИЧЕСКОЙ МЕТАМОРФОЗЫДО МЕТАФОРЫ ГЕНЕЗИСАК ПРОБЛЕМЕ ПОНИМАНИЯ ИСТОРИЧЕСКОГО ВРЕМЕНИ
Authors: К. Поласик-Вжосек , В. Вжосек 
Published: November 2024

Авторы исходят из того, что время не обладает универсальной природой и, как и всё в культуре, имеет статус исторической относительности. В качестве источника познания исторического времени принимаются исторические дискурсы, которые реализуют выработанные культурой темпоральные исторические представления, т.е. воплощают в наррации конкретные господствующие представления об историческом мире. Авторы приходят к заключению, что историческое время, истоком которого является магическое мышление, представляет собой конституирующий составной элемент исторического мышления, возникает вместе с ним, а также вместе и в связи с ним подвергается изменениям. Из происходящих в нем изменений берутся известные нам примеры исторических форм мышления и речи, в т.ч. в форме историографических шедевров, являющихся одновременно и шедеврами культуры, которые содержат в себе явные и скрытые следы своего происхождения.
The authors suggest that time does not have universal nature and, everything in culture, has a status of historical relativity. A source for knowledge of historical time is in historical discourses, which implement temporal views of history produced by a culture, i.e., present dominant views of historical world in a narration. The authors conclude that historical time, which has its source in magical thought, is created with it, and is being changed with and in connection to it. Out of all changes, the authors explore historical forms of thought and speech, including historiographical masterpieces that are also cultural masterpieces and bear traces of their origin, external and internal.
ЗАБЫТЫЙ ЛОНДОНСКИЙ КОРРЕСПОНДЕНТРОССИЙСКИХ ЖУРНАЛОВСЕМЕН ИСААКОВИЧ РАПОПОРТ
Authors:  И.  Чикалова 
Published: November 2024

Автор продолжает серию публикаций, посвященных жизни и творчеству забытых российских дореволюционных англоведов – ученых и публицистов. В фокусе исследовательского интереса – личность Семена Исааковича Рапопорта (1858–1934), c 1891 г. постоянно проживавшего в Лондоне и вплоть до 1917 г. печатавшего корреспонденции и очерки об Англии в российских периодических изданиях: газетах «Новости», «Неделя» и журналах «Книжки недели», «Северный вестник», «Русское экономическое обозрение», «Вестник Европы», «Мир божий», «Образование», «Русская мысль», «Вестник финансов, промышленности и торговли».
The article continues a series of publications by the author that are dedicated to the life and works of a forgotten Russian pre-revolutionary expert in British Studies – scholars and publicists. The focus of the research is centered on the personality of the journalist Semen Isaakovich Rapoport (1858–1934), who from 1891 was based in London and up to 1917 had been published articles from England in the Russian periodicals such as newspapers “Novosti”, “Nedelia”, journals “Knizki Nedeli”, “Severnyi Vestnik”, “Russkoe Ekonomicheskoe Obozrenie”, “Vestnik Evropy”, “Mir Bozyi”, “Obrazovanie”, “Russkaia Mysl”, “Vestnik Finansov, Promyshlennosti i Torgovli”. It is presented “geography” and thematic varieties of the Rapoport’s publishing activity. Well known to his contemporaries, his name appeared to have been forgotten for long years after the revolution in Russia.
ЮБИЛЕЙНЫЕ ИСТОРИИ УНИВЕРСИТЕТОВ КАК ЖАНРСОВРЕМЕННОЙ РОССИЙСКОЙ ИСТОРИОГРАФИИ
Authors:  Л.  Репина 
Published: November 2024

Современная историография университетской истории в России носит ярко выраженный историко-культурный характер, что является общим для ряда формирующихся направлений. В статье речь идет об особом ракурсе рассмотрения истории российских университетов, а именно – в свете исследований коллективной исторической памяти и хронотопических характеристик интеллектуальной культуры. Автор подчеркивает специфическую природу «университетских историй», их сущностные отличия от «университетских исследований», ставящих перед собой задачу деконструкции предшествующей, «изобретенной» традиции. Число новых юбилейных университетских историй, выступающих как феномен мемориальной культуры, не столь велико, но именно они дают корпоративному самосознанию полноту темпоральной перспективы. Историческая перспектива longue durée, устремленная от «начала начал» к текущему моменту и далее – в грядущее, актуализируется в условиях процедуры «оптимизации», навязанной университетам извне. Юбилейные истории, создающие «Я-образ» университета в жанре корпоративной «автобиографии», начиная с сакрального акта «рождения», способствуют консолидации сообщества, связывая профессуру и студентов разных поколений, предъявляя университет «внешнему миру» и утверждая его высокую миссию и статус в обществе.
Contemporary Russian historiography of the history of universities has a clear historical-cultural bias, and this is shared by a number of important historiographical trends. The article explores a particular angle in the studying of Russian universities, namely, the context of collective historical memory and chronotopic characteristics of intellectual culture. The author emphasizes a specific nature of “university histories”, their difference from “university studies” that aim at deconstruction of a previous, “invented” tradition. A number of new jubilee histories of universities, a phenomenon of memorial culture, is not too high, but these histories give temporal perspective to corporate self-consciousness. A longue durée historical perspective that goes from the “point of origin” to the present and further – to the future, is actualized during the process of “optimization” forced upon universities. Jubilee histories that create “I-image” of a university in a genre of a corporate “biography”, from a sacral act of “birth”, consolidates a community and links professors and students of various generations by presenting a university to the “outside world” and establishing its high mission and social status.
О ВАРВАРАХ И ТИРАНАХ: СКРЫТОЕ ВАРВАРСТВО КАК ЭЛЕМЕНТ ПОЛИТИЧЕСКОЙ КРИТИКИ В ПОЗДНЕЙ РИМСКОЙ ИМПЕРИИ
Authors: М.А. ВЕДЕШКИН 
Published: November 2024

В статье анализируется использование дискурса скрытого варвара в политической пропаганде IV столетия на примере анализа биографий императоров Галерия и Максимина Дазы, представленных в труде христианского ритора Лактанция «De mortibus persecutorum». Делается вывод, что свидетельства церковного историка о характере вышеназванных императоров прямо опровергаются данными менее ангажированных авторов. Выдвигвается предположение, что, создавая образы гонителей, Лактанций использовал традиционный для римской литературы набор топосов, принятых для характеристики «тиранов», и усиливал свои обвинения, подчеркивая их варварское происхождение. Делается предположение, что основная часть описания Галерия была заимствована Лактанцием из сделанной веком ранее историком Геродианом характеристики императора Максимина Фракийца.
The article analyzes the use of discourse of the hidden barbarian in political propaganda of the 4th century on the example of the biographies of emperors Galerius and Maximinus Daza, presented in the work by Lactantius «De mortibus Persecutorum». It is concluded that the testimony of the historian on the character and ethnic origin of the aforementioned emperors is directly refuted by the data of less engaged authors. The assumption is made that while creating the image of the persecutors, Lactantius utilized a set of traditional topoi used to characterize the «tyrants» and enforced his accusations by stressing their barbaric origin. It is assumed that the main part of the Galerius’ description was borrowed by Lactantius from the characteristics of the emperor Maximinus Thracius made a century earlier by the historian Herodian.
ГРЕКИ И ВАРВАРЫ В РАССКАЗАХ ОБ ОСНОВАНИИ ЛАМПСАКИ И МАССАЛИИ
Authors: Д.М. КАМАРИ 
Published: November 2024

Статья посвящена вопросу о сходстве рассказов античных авторов об основании фокейцами Лампсаки и Массалии, которые были написаны в разные времена. Автор анализирует оба рассказа, чтобы определить, насколько описываемые античными авторами ранние связи между греками и варварами соответствовали реальным историческим отношениям.
The article is devoted to the issue of similarity of the stories of ancient authors about the founding by the Phocaeans of Lampsacus and Massalia, which were written by Greeks at different times. The author analyzes both stories to determine how the described by ancient authors early contacts between Greeks and barbarians corresponded to real historical relations.