bluuebunny/crossref_metadata_2025_split huggingface dataset:
Natural Evolution of Incomplete Reperfusion in Patients Following Endovascular Therapy After Ischemic Stroke
Authors: Mujanovic Adnan , Windecker Daniel , Cimflova Petra , Meinel Thomas R. , Seiffge David J. , Auer Elias , Boulouis Grégoire , Arnold Marcel , Serrallach Bettina L. , Rohner Roman , Janot Kevin , Dobrocky Tomas , Hill Michael D. , Goyal Mayank , Piechowiak Eike I. , Gralla Jan , Fischer Urs , Kaesmacher Johannes 
Published: November 2024

BACKGROUND:
A third of endovascularly treated patients with stroke experience incomplete reperfusion (expanded Thrombolysis in Cerebral Infarction [eTICI] <3), and the natural evolution of this incomplete reperfusion remains unknown. We systematically reviewed the literature and performed a meta-analysis on the natural evolution of incomplete reperfusion after endovascular therapy.

METHODS:
A systematic review of MEDLINE, Embase, and PubMed up until March 1, 2024, using a predefined strategy. Only full-text English-written articles reporting rates of either favorable (ie, delayed reperfusion (DR) or no new infarct) or unfavorable progression (ie, persistent perfusion deficit or new infarct) of incompletely reperfused tissue were included. The primary outcome was the rate of DR and its association with functional independence (modified Rankin Scale score, 0–2) at 90 days postintervention. Pooled odds ratios with 95% CIs were calculated using a random-effects model.

RESULTS:
Six studies involving 950 patients (50.7% female; median age, 71 years; interquartile range, 60–79) were included. Four studies assessed the evolution of incomplete reperfusion on magnetic resonance imaging perfusion imaging, while 2 studies used diffusion-weighted imaging and noncontrast computed tomography imaging, where new infarct was used to denote unfavorable progression. Five studies defined incomplete reperfusion as eTICI 2b50 or 2c. DR occurred in 41% (interquartile range, 33%–51%) of cases 24 hours postintervention. Achieving DR was associated with a higher likelihood of functional independence at 90 days (odds ratio, 2.5 [95% CI, 1.9–3.4]).

CONCLUSIONS:
Nearly half of eTICI <3 patients achieve DR, leading to favorable clinical outcomes. This subgroup may derive limited or potentially harmful effects from pursuing additional reperfusion strategies (eg, intra-arterial lytics or secondary thrombectomy). Accurately predicting the evolution of incomplete reperfusion could optimize patient selection for adjunctive reperfusion strategies at the end of an intervention.

REGISTRATION:

URL:
https://www.clinicaltrials.gov
; Unique identifiers: NCT05499832.
Conformalizing Machine Translation Evaluation
Authors: Zerva Chrysoula , Martins André F. T. 
Published: November 2024

Abstract
Several uncertainty estimation methods have been recently proposed for machine translation evaluation. While these methods can provide a useful indication of when not to trust model predictions, we show in this paper that the majority of them tend to underestimate model uncertainty, and as a result, they often produce misleading confidence intervals that do not cover the ground truth. We propose as an alternative the use of conformal prediction, a distribution-free method to obtain confidence intervals with a theoretically established guarantee on coverage. First, we demonstrate that split conformal prediction can “correct” the confidence intervals of previous methods to yield a desired coverage level, and we demonstrate these findings across multiple machine translation evaluation metrics and uncertainty quantification methods. Further, we highlight biases in estimated confidence intervals, reflected in imbalanced coverage for different attributes, such as the language and the quality of translations. We address this by applying conditional conformal prediction techniques to obtain calibration subsets for each data subgroup, leading to equalized coverage. Overall, we show that, provided access to a calibration set, conformal prediction can help identify the most suitable uncertainty quantification methods and adapt the predicted confidence intervals to ensure fairness with respect to different attributes.1
Distribution of the soybean cyst nematode, Heterodera glycines, in green soybean cultivation areas of Japan and its control measures
Authors: Toyota Koki , Kato Risako , Takeda Ai , Perry Roland N. 
Published: November 2024

Summary
Green soybean (edamame), an early-harvested soybean, is a popular vegetable in Asia and is recognised as a healthy vegetable in the other parts of the world. In Japan, edamame yield has gradually decreased over the last 30 years, despite similar cultivation areas. Damage caused by the soybean cyst nematode (SCN), Heterodera glycines, is one of the main causes. We surveyed the distribution of SCN in different locations and found a wide distribution of SCN across Japan. Different control measures are available, such as chemical control using fumigants or a granular type of nematicide, solarisation, and rotation with non-host crops. We are developing a new type of biological control method, which comprises short-term field cultivation and soil incorporation of mung bean. This method not only decreases the SCN density in soil but also mitigates soil erosion and nitrate leaching. For future SCN control it is essential to establish an environmentally friendly management strategy.
On the ability of the LR method to detect bias when there is pedigree misspecification and lack of connectedness
Authors: Pardo Alan M. , Legarra Andres , Vitezica Zulma G. , Forneris Natalia S. , Maizon Daniel O. , Munilla Sebastián 
Published: November 2024

Abstract
Background
Cross-validation techniques in genetic evaluations encounter limitations due to the unobservable nature of breeding values and the challenge of validating estimated breeding values (EBVs) against pre-corrected phenotypes, challenges which the Linear Regression (LR) method addresses as an alternative. Furthermore, beef cattle genetic evaluation programs confront challenges with connectedness among herds and pedigree errors. The objective of this work was to evaluate the LR method's performance under pedigree errors and weak connectedness typical in beef cattle genetic evaluations, through simulation.

Methods
We simulated a beef cattle population resembling the Argentinean Brangus, including a quantitative trait selected over six pseudo-generations with a heritability of 0.4. This study considered various scenarios, including: 25% and 40% pedigree errors (PE-25 and PE-40), weak and strong connectedness among herds (WCO and SCO, respectively), and a benchmark scenario (BEN) with complete pedigree and optimal herd connections.

Results
Over six pseudo-generations of selection, genetic gain was simulated to be under- and over-estimated in PE-40 and WCO, respectively, contrary to the BEN scenario which was unbiased. In genetic evaluations with PE-25 and PE-40, true biases of − 0.13 and − 0.18 genetic standard deviations were simulated, respectively. In the BEN scenario, the LR method accurately estimated bias, however, in PE-25 and PE-40 scenarios, it overestimated biases by 0.17 and 0.25 genetic standard deviations, respectively. In herds facing WCO, significant true bias due to confounding environmental and genetic effects was simulated, and the corresponding LR statistic failed to accurately estimate the magnitude and direction of this bias. On average, true dispersion values were close to one for BEN, PE-40, SCO and WCO, showing no significant inflation or deflation, and the values were accurately estimated by LR. However, PE-25 exhibited inflation of EBVs and was slightly underestimated by LR. Accuracies and reliabilities showed good agreement between true and LR estimated values for the scenarios evaluated.

Conclusions
The LR method demonstrated limitations in identifying biases induced by incomplete pedigrees, including scenarios with as much as 40% pedigree errors, or lack of connectedness, but it was effective in assessing dispersion, and population accuracies and reliabilities even in the challenging scenarios addressed.
A novel computational approach for the mining of signature pathways using species co-occurrence networks in gut microbiomes
Authors: Kim Suyeon , Thapa Ishwor , Ali Hesham 
Published: November 2024

Abstract
Background
Advances in metagenome sequencing data continue to enable new methods for analyzing biological systems. When handling microbial profile data, metagenome sequencing has proven to be far more comprehensive than traditional methods such as 16s rRNA data, which rely on partial sequences. Microbial community profiling can be used to obtain key biological insights that pave the way for more accurate understanding of complex systems that are critical for advancing biomedical research and healthcare. However, such attempts have mostly used partial or incomplete data to accurately capture those associations.

Methods
This study introduces a novel computational approach for the identification of co-occurring microbial communities using the abundance and functional roles of species-level microbiome data. The proposed approach is then used to identify signature pathways associated with inflammatory bowel disease (IBD). Furthermore, we developed a computational pipeline to identify microbial species co-occurrences from metagenome data at various granularity levels.

Results
When comparing the IBD group to a control group, we show that certain co-occurring communities of species are enriched for potential pathways. We also show that the identified co-occurring microbial species operate as a community to facilitate pathway enrichment.

Conclusions
The obtained findings suggest that the proposed network model, along with the computational pipeline, provide a valuable analytical tool to analyze complex biological systems and extract pathway signatures that can be used to diagnose certain health conditions.
Comparison between ultrasound guided erector spinae plane block and paravertebral block on acute and chronic post mastectomy pain after modified radical mastectomy: randomized controlled trial
Authors: Amr Samy Abdelrahman , Othman Ahmed Hassan , Ahmed Eman Hassan , Naeem Romany Gergis , Kamal Shereen Mamdouh 
Published: November 2024

Abstract
Background
Inadequate acute postoperative pain management is linked to the effect on the stress response and development of chronic pain. A unique regional anaesthetic method that is becoming more important for postoperative pain management is erector spinea plane block (ESP). Since its initial description, physicians have questioned weather this novel easy method can take the place of paravertebral block (PVB). Our goal was to evaluate, in contrast to control group, the effects of ESP & PVB on acute and chronic post-mastectomy pain.

Methods
One hundred and five female patients undergoing modified radical mastectomy participated in this study, randomly allocated into three equal groups: erector spinae plane block (ESP), thoracic paravertebral (TPV), and control groups. Both blocks were ultrasound-guided with 20 ml 0.25% bupivacaine according to patients’ group, control group was administered standard general anaesthesia without intervention. Total morphine consumption in the first 24 h postoperative was the primary outcome. The secondary outcomes were time to the first analgesia, (Visual Analogue Scale)VAS score, serum level of cortisol and prolactin, sedation score, side effects, and LANSS scores in the first, third, and sixth postoperative months were among the variables compared between groups.

Results
Total morphine consumption in the first 24 h was significantly higher in control than ESP and TPV groups (10.74 ± 1.37, 8.17 ± 1.69, 5.70 ± 1.95 respectively p < 0.001). Time to first analgesic request was the shortest in control versus ESP and TPV groups as (4.37 ± 3.06, 8.13 ± 1.75, 10.64 ± 1.83 h respectively p ˂0.001). ESP and TPV had significantly lower cortisol and prolactin levels compared to control (p < 0.001). The highest LANSS scores were in the control group in the first, third, and sixth months compared with ESP and TPV, with no significant difference between ESP and TPV.

Conclusion
ESP and TPV blocks provided superior early postoperative analgesia and reduced stress response compared to the control group in female patients undergoing modified radical mastectomy. PVB is better than ESB in acute postoperative pain management (the total morphine consumption VAS score and time of first analgesic request). Both techniques showed better long-term outcomes compared to the control group regarding LANSS score in the 6-month follow-up.

Trial registration
https://www.ClinicalTrials.gov trial registry (identifier NCT04498234 on 04/08/2020).
The complexity of needs and roles of family members during breast cancer rehabilitation: a qualitative study
Authors: Malmström Marlene , Holst-Hansson Annette , Olsson Möller Ulrika 
Published: November 2024

Abstract
Background
Family members play a crucial role in supporting women with breast cancer during their recovery. In the complex situation of being an informal caregiver, their own health and ability to support the patient needs to be acknowledged. The aim was to explore the experiences, needs and roles of family members throughout the rehabilitation process of women with breast cancer.

Methods
A qualitative study was conducted, involving semi-structured individual telephone interviews with 20 purposefully selected family members of women with breast cancer (13 men aged 24–79 years, 7 women aged 19–76 years). Data analysis utilized conventional content analysis and used “casing” as the analysis technique. The study is part of the ReScreen randomized controlled trial and all participants gave informed consent.

Results
The interviews revealed significant variation among family members, leading to the emergence of different typologies based on their reactions and specific preconditions. These typologies included: 1) The case of the assertive and confident team leader, 2) The case of the frustrated but persistent guardian, 3) The case of the reassured bystander, and 4) The case of the neglected outsider. While not mutually exclusive, the cases demonstrated clear similarities and differences in whether individuals felt secure or insecure in the rehabilitation process and their level of involvement in this process. Some described feelings of being involved and active in the process while others experienced not being involved and described feelings of abandonment. However, regardless of their role, family members reported that their own health was seldom considered by healthcare professionals.

Conclusions
This study sheds light on the concept of “we-disease,” where the role of a family member is interrelated with factors such as their health literacy, supporting role, level of involvement, relationship, and identity during the patient's rehabilitation process. This highlights significant divergence in whether family members perceive the rehabilitation process as a collaborative effort or an individual challenge. These perceptions greatly impact their own well-being and ability to support women with breast cancer, underscoring the importance of recognizing family members as informal caregivers and offering tailored support from healthcare professionals when needed.

Trial registration
ClinicalTrials.gov NCT03434717. Registered February 15, 2018.
Cervical cancer screening uptake in Arab countries: a systematic review with meta-analysis
Authors: Ahmed Hebatalla Abdelmaksoud Abdelmonsef , Abbas Mohammed Hamdi , Hussein Hussein Awad , Nasr Rehab Salah Fathy , Lashen Amira Ahmed , Khaled Heba , Azzam Ahmed 
Published: November 2024

Abstract
Background
Cervical cancer, though one of the most common cancers affecting women globally, holds immense potential for prevention through screening. Therefore, we conducted this meta-analysis to assess the rate of cervical cancer screening in Arab countries and identify barriers among those who did not participate.

Methods
A comprehensive search was conducted from January 1st to June 1st,2024, including all observational studies that reported cervical cancer screening uptake in any Arab country. A meta-analysis was performed using a random-effects model to estimate the pooled prevalence, and sensitivity analyses were conducted to test the robustness of the findings. The study followed PRISMA guidelines.

Results
This meta-analysis, covering 55 studies and 204,940 Arab women, found an overall cervical cancer screening uptake rate of 18.2% (95% CI: 13.9–23.6), with sensitivity analysis confirming the reliability of this estimate. Country disparities were evident, with Bahrain having the highest uptake at 44.1%, while Somalia had the lowest at 8.9%. Among women who underwent screening, the majority were ever-married (94.7%) and held positive attitudes towards screening (91.0%). Barriers to screening were common among women who did not participate, with the most frequent reasons being a lack of information (25.1%), the misconception of feeling healthy (24.5%), fear of the procedure (19.3%), and feelings of embarrassment (13.2%). Additionally, women who were screened had lower perceived barrier scores (SMD = -0.466) and higher perceived benefits scores (SMD = 0.379) than those who were not (p < 0.05).

Conclusion
This meta-analysis reveals a low overall cervical cancer screening uptake (18.2%) among Arab women. Key barriers such as lack of information, fear, the misconception of feeling healthy, and embarrassment hinder uptake. This alarmingly low rate underscores the urgent need for targeted interventions to address these barriers and promote awareness of early detection’s life-saving potential.
Association between parents’ perceived social support and children’s psychological adjustment: a cross-sectional study
Authors: Hosokawa Rikuya , Katsura Toshiki 
Published: November 2024

Abstract
Background
This study examined the relationship between parents’ perceived social support and their children’s psychological adjustment.

Methods
This cross-sectional survey study was conducted in 52 kindergartens and 78 preschools in Nagoya, Aichi, a major metropolitan area in Japan. Parents of eighth-grade children aged 13–14 years (N = 1,195) completed a questionnaire. A total of 602 valid responses were received. To accurately assess the relationship between parents’ perceived social support and behavioral characteristics, respondents diagnosed with a developmental disability or who failed to answer the required questionnaire items were excluded from the analysis. Consequently, 536 (89.0%) of the 602 participants met the eligibility criteria.

Results
The results indicated that the stronger the social support for parents, the lower the scores for externalizing and internalizing problems, and the higher the scores for prosociality. Conversely, insufficient social support may pose a risk to parental mental health and lead to suboptimal parenting practices. Issues in parental mental health adversely affect parenting, leading to fewer positive interactions with young children, increased rates of negative interactions and hostility, diminished communication, and delayed responses to children’s behaviors.

Conclusions
These results underscore the significant influence of parents’ perceptions of social support on their parenting beliefs and behaviors, which may, in turn, affect the development of their children’s mental health. Therefore, parents’ perceptions of social support are likely positively associated with children’s mental health.
Occupational risks of COVID-19: a case-cohort study using health insurance claims data in Germany
Authors: Romero Starke Karla , Mauer René , Hegewald Janice , Bolm-Audorff Ulrich , Brückner Gabriela , Schüssel Katrin , Schröder Helmut , Seidler Andreas 
Published: November 2024

Abstract
Background
Studies on occupation and COVID-19 infection that cover a range of occupational groups and adjust for important confounders are lacking. This study aimed to estimate occupational risks of hospitalization with COVID-19 by taking into account sociodemographic factors and previous comorbidities.

Methods
We applied a case-cohort design using workers insured with one of Germany’s largest statutory health insurers as a data source for occupational and demographical information as well as for information on comorbidities. Cox regression models with denominator weights for cases and controls assessed relative risks of hospitalization with COVID-19 in 2020.

Results
The study consisted of 11,202 COVID-19 cases and 249,707 non-cases. After adjusting for age, sex, number of pre-existing comorbidities, and socioeconomic status, we found at least doubled risks for occupations in theology and church work (HR = 3.05; 95% CI 1.93–4.82), occupations in healthcare (HR = 2.74; 95% CI 2.46–3.05), for bus and tram divers (HR = 2.46; 95% CI 2.04–2.97), occupations in meat processing (HR = 2.16; 95% CI 1.57–2.98), and professional drivers in passenger transport (e.g. taxi drivers) (HR = 2.00; 95% CI 1.59–2.51). In addition, occupations in property marketing and management, social workers, laboratory workers, occupations in personal care (e.g. hairdressers), occupations in housekeeping and occupations in gastronomy all had statistically significantly increased risks compared to the reference population (administrative workers).

Conclusions
We identified occupations with increased risks for hospitalization with COVID-19. For those having a doubled risk it can be assumed that COVID-19 diseases are predominantly occupationally related. By identifying high-risk occupations in non-healthcare professions, effective measures to prevent infections in the workplace can be developed, also in case of a future pandemic.
Swimmer arm-to-shoulder test for early differentiation between shoulder and cervical spine pathology in patients with shoulder pain
Authors: Hamoud Hesham , Aly Hany , Elmotaleb Yasser A. , Ghit Mohamad M. , Mosalam Ahmad , Nasrallah Tarek M. , El Zokm Saad M. , Fawzy Ibrahim , Bayoumy Abdelwahab N. , Mohamed Maha S. , Elazab Seham A. , Elmesiry Amal M. , Rageh Eman A. , Moussa Mai A. , Elyasaki Ahmed , Refaat Sherif , Elhilasy Ahmed M. , El deeb Ahmed M. , Elshaitany Walid , Eltabiey Ashraf 
Published: November 2024

Abstract
Background
Several tests have been suggested for screening and diagnosis of cervical spine and shoulder girdle conditions underlying shoulder pain with variable degrees of clinical accuracy. The present study aimed to test the reliability, clinical benefit and screening value of the Swimmer Arm-to-Shoulder (SAS) test; a new clinical test developed to differentiate shoulder impingement from cervical radiculopathy in patients with shoulder pain of ≤ 12 weeks.

Methods
The study included 718 patients aged 40–65 years, with unilateral and localized shoulder girdle pain lasting for ≤ 12 weeks. Diagnosis based on clinical, electromyography and radiological findings was considered as the reference gold standard for test assessment.

Results
Clinical diagnosis identified shoulder pathology in 288 patients (40.1%) and cervical spine pathology in 430 patients (59.9%). SAS test was positive in 274 patients (38.2%). The SAS test proved to be effective in distinguishing shoulder from cervical spine pathology with a sensitivity of 89.2% (95% CI: 85.0-92.6%), specificity of 96.1% (95% CI: 93.8–97.7%), PPV of 93.8% (95% CI: 90.5–96.0%), NPV of 93.0% (95% CI: 90.5–94.9%), LR + of 22.6% (95% CI: 14.1–36.0%), LR- of 0.11 (95% CI: 0.08–0.16) and accuracy of 93.3% (95% CI: 91.2–95.0%).

Conclusions
SAS test is an easy to perform, patient dependent and reliable as a screening test and diagnosis confirmatory test.