bluuebunny/crossref_metadata_2025_split huggingface dataset:
Validity of Mini-Fluid Challenge for Predicting Fluid Responsiveness Following Liver Transplantation
Authors: Mukhtar Ahmed , Awad Maha , Elayashy Mohamed , Hussein Amr , Obayah Gihan , Adawy Akram El , Ahmed Mai , Dahab Hisham Abul , Hasanin Ahmed , Elfouly Amr , Abdo Mostafa , Abdelaal Amr , Teboul Jean 
Published: March 2019

Abstract
Background

Mini-fluid challenge is a well tested and effective tool to predict fluid responsiveness under various clinical conditions. However, mini-fluid challenge has never been tested in patients with end-stage liver disease. This study investigated whether infusion of 150 ml albumin 5% can predict fluid responsiveness in cirrhotic patients following liver transplant.

Methods

Fifty patients receiving living donor liver transplant were included in the analysis. Mini-fluid challenge composed of 150 ml of albumin 5% administered over 1 min in three consecutive 50-ml fluid boluses. An additional 350 ml was then infused at a constant rate over 15 min (for a total of 500 ml). Stroke volume (SV) was measured as the product of the subaortic velocity time integral (VTI) and left ventricular outflow tract (LVOT) area. Fluid responsiveness was defined as an increase in SV by ≥15% after the infusion.

Results

Fifty patients were enrolled in the study. Fourteen patients were classified with Child A, 15 patients with Child B, and 21 patients with Child C cirrhosis. Thirty four patients were fluid responders and 16 patients were fluid non-responders. After 150 ml of albumin 5%, the SV increased significantly in our cohort. The area under receiver operating curve (AUROC) was 0.7 (95% confidence interval [CI] 0.5–0.8, P = 0.005). In subgroup analysis, the SV increased significantly after mini fluid challenge in the Child A group (P = 0.017) but not Child B or C groups (P = 0.3 and 0.29, respectively). The AUROC for mini-fluid challenge in the Child A group was 0.86 (95% confidence interval [CI] 0.6–0.9, P = 0.0004), while mini-fluid challenge failed to discriminate between responders and non-responders in Child B and C groups.

Conclusion

A mini-fluid challenge of 150 ml albumin 5% can predict fluid responsiveness in liver transplant patients with fair sensitivity and specifiicty. Subgroup analyis revealed that minifluid challenge can predict fluid responsiveness in patients with Child A cirrhosis but not patients with Child B or C cirrhosis

Trial Registration Number

NCT03396159. (Prospective registered). Initial registration date was 10/01/2018
Improving the reliability of professional psychological selection of aviation specialists
Authors: Arinicheva O. V. , Malishevsky A. V. 
Published: March 2019

The research used the Thomas-Kilman Conflict Mode Instrument (TKI) (more specifically, TKI-R, the Russian adaptation by N.V. Grishina) psychodiagnostic procedure to assess the behaviour strategy in conflict situations, as well as the Buss-Durkee Inventory to determine the tendency of subjects to various forms of aggressive behaviour. Statistical processing of the findings was done using the Bravais-Pearson correlation coefficient and Pearson’s criterion.Results.At the first stage of the multipurpose experiment 48 student dispatchers were surveyed, at the second stage the total of 603 subjects were surveyed (students of the Saint Petersburg State University of Civil Aviation and the Institute of Philology, Foreign Languages and Media Communications of the Irkutsk State University), i.e. while emphasizing operator professions in order to improve the validity of the experiment the sample was significantly extended to include, among others, students of the humanities. It was found that the results of the Buss-Durkee Inventory have an inverse correlation with the tendency to an adaptation strategy and direct correlation with the tendency to rivalry and collaboration strategies. According to Pearson’s fitting criterion, there are significant differences in the manifestation of such behaviour styles as rivalry and avoidance between pilot and humanities students, while for the samples of males and females the differences are in the manifestation of such behaviour stiles as rivalry, avoidance and compromise. Females are significantly less inclined to rivalry and somewhat more inclined to avoidance and compromise as compared to males. There are also no observable crucial differences between the intercorrelations of the TKI-R results of the first and second stages of the experiment. The authors’ findings were compared with the published results of the survey of the students of the Tuvan State University and Yaroslavl State Medical University, as well as with the results of surveys of athletes and business owners.Conclusions.By generalizing own findings and those set forth in other authors’ publications, we can conclude that uncooperative behaviour of all tested students is dominated by average manifestation of strategies of competing, collaborating, compromising, avoiding and accommodating, which indicates the ability of the subjects of this age for flexible behaviour in conflict situations subject to the specific conditions of interaction. That means that students, unlike the success-seeking business owners, while prioritizing collaboration and compromise in conflict situations, flexibly use other behaviour strategies. This must be taken into consideration when planning measures aimed at improving the reliability of professional psychological selection in commercial aviation. It appears that in view of the above reasons, the application of the TKI-R procedure in the professional psychological selection of aviation specialists is unviable.
Clinical Operational Tolerance and Immunosuppression Minimization in Kidney Transplantation: Where Do We Stand?
Authors: Manzia Tommaso Maria , Gazia Carlo , Baiocchi Leonardo , Lenci Ilaria , Milana Martina , Santopaolo Francesco , Angelico Roberta , Tisone Giuseppe 
Published: March 2019

Background:
The 20th century represents a breakthrough in the transplantation era, since
the first kidney transplantation between identical twins was performed. This was the first case of
tolerance, since the recipient did not need immunosuppression. However, as transplantation became
possible, an immunosuppression-free status became the ultimate goal, since the first tolerance case
was a clear exception from the hard reality nowadays represented by rejection.

Methods:
A plethora of studies was described over the past decades to understand the molecular
mechanisms responsible for rejection. This review focuses on the most relevant studies found in the
literature where renal tolerance cases are claimed. Contrasting, and at the same time, encouraging
outcomes are herein discussed and a glimpse on the main renal biomarkers analyzed in this field is
provided.

Results:
The activation of the immune system has been shown to play a central role in organ failure,
but also it seems to induce a tolerance status when an allograft is performed, despite tolerance is still
rare to register. Although there are still overwhelming challenges to overcome and various immune
pathways remain arcane; the immunosuppression minimization might be more attainable than
previously believed.

Conclusion:
Multiple biomarkers and tolerance mechanisms suspected to be involved in renal
transplantation have been investigated to understand their real role, with still no clear answers on the
topic. Thus, the actual knowledge provided necessarily leads to more in-depth investigations,
although many questions in the past have been answered, there are still many issues on renal
tolerance that need to be addressed.
Attenuating Effect of Portulaca oleracea Extract on Chronic Constriction Injury Induced Neuropathic Pain in Rats: An Evidence of Anti-oxidative and Anti-inflammatory Effects
Authors: Forouzanfar Fatemeh , Hosseinzadeh Hossein , Khorrami Mohammad B. , Asgharzade Samira , Rakhshandeh Hassan 
Published: March 2019

Background:
Neuropathic pain responds poorly to drug treatments. The present study investigated
the therapeutic effect of Portulaca oleracea, in chronic constriction injury (CCI)-induced
neuropathic pain in rats.

Objective & Methods:
Neuropathic pain was performed by putting four loose ligatures around the sciatic
nerve. CCI resulted in the development of heat hyperalgesia, mechanical allodynia and cold allodynia
accompanied by an increase in the contents of TNF-α, IL1β, malondialdehyde, with a reduction
in total thiol content.

Results:
Administration of Portulaca oleracea (100 and 200 mg/kg intraperitoneal) for 14 days in CCI
rats significantly alleviated pain-related behaviors, oxidative damage and inflammatory cytokines in a
dose-dependent manner.

Conclusion:
In conclusion, it is suggested that the antinociceptive effects of Portulaca oleracea might
be due to antioxidant and anti-inflammatory properties.
PENGARUH MODEL PEMBELAJARAN OPEN ENDED BERBASIS PENILAIAN PROYEK TERHADAP KOMPETENSI PENGETAHUAN PPKn SISWA
Authors: Wiyasa IKN 
Published: March 2019

The purpose of this research was to know the significant difference of knowledge competence of PPKn group of students which were taught by Open Ended learning model based on project assessment with group of students taught by conventional learning in fourth grades of SD Gugus I Gianyar Sub District Academic Year 2017/2018. This research was a quasi-experimental study with non-equivalent group design. Population in this research were all fourth graders of SD Gugus I Gianyar Sub District Academic Year 2017/2018 which amounted to 343 people. Determination of the sample in this reseach used random sampling technique with existing class scramble, then to determin of both of experimental and control groups were drawed so the fourth grade Melati SD Negeri 2 Gianyar as 36 students as experimental class and fourth grade A SD Negeri 1 Gianyar as much 44 students as a control class group. The student's knowledge competence data were collected with an ordinary double-choice objective test instrument of 30 validated questions. The gain score normalization value of fourth grades Melati under the average of 15 people and which reached an average of 21 people while the gain score normalization value of fourth grades A which were below the average of 21 people and who reached an average of 23 people. The result of t-test analysis shows tcalculate = 2,494> ttable (ɑ = 0,05, dk = 78) = 1,991 so H0 was rejected and Ha accepted. In accordance with these results can be concluded Open Ended learning model based on project assessment affect the competence of knowledge PPKn fourth graders of SD Gugus I Gianyar Sub District Academic Year 2017/2018. For researchers who have similarities of variables, the results of this research can be used as a relevant research. Keywords: open ended, project assessment, PPKn
PENERAPAN MODEL PEMBELAJARAN DISCOVERY LEARNING UNTUK MENINGKATKAN MOTIVASI DAN PRESTASI BELAJAR PRAKARYA DAN KEWIRAUSAHAAN SISWA
Authors: Ardana I Komang 
Published: March 2019

Tujuan dari diadakannya penelitian ini adalah untuk meningkatkan motivasi dan prestasi belajar pada siswa SMK Negeri 2 Singaraja Tahun Pelajaran 2016/2017 dengan model pembelajaran Discovery Learning mata pelajaran Prakarya dan kewirausahaan. Penelitian ini adalah penelitian tindakan kelas (PTK). Subyek penelitian yang akan dijadikan penelitian adalah siswa kelas XI Tata Boga 4 SMK N 2 Singaraja tahun pelajaran 2016/2017 yang berjumlah 41 orang Laki-laki 25 orang dan Perempuan 16 orang Sedangkan obyek penelitian adalah Motivasi siswa dan Prestasi belajar. Data mengenai prestasi belajar siswa yang dikumpulkan pada akhir setiap siklus dengan menggunakan tes. Data mengenai Motivasi belajar yang dikumpulkan dengan menggunakan lembar angket motivasi belajar berupa kuesioner. Analisis data yang digunakan pada penelitian ini menggunakan analisis data deskriptif. Berdasarkan analisis data yang dilakukan dapat disimpulkan bahwa implementasi model Discovery Learning dapat meningkatkan motivasi dan prestasi belajar Prakarya dan Kewirausahaan siswa kelas XI Tata Boga 4 SMK Negeri 2 Singaraja Tahun Pelajaran 2016/2017
Analisis pengaruh service recovery terhadap loyalitas pelanggan dalam jasa telepon seluler
Authors: Antika Mia 
Published: March 2019

The objectives of this research is to examine the impact of service recovery toward trust, and customer loyalty. To look at the connection between service recovery and customer loyalty this research used justice perspective that included procedural justice, interactional justice and distributive justice. The setting of this research was information technology business. The research was conducted in area of Surakarta regency with the customer phone operator as research respondent. This research used convinience sampling and employed 150 respondent that grouped by complaint and non-complaint customer. Regression analysis was used in this research to analyse the data. Research indicated that procedural justice have significant impact toward customer satisfaction. In contrast, distributive and interactional justive did not significant impact toward customer satisfaction. This research also found that trust and customer satisfaction significantly impact toward trust and customer loyalty. In addition, this result found that non-complaint respondent were more trust and loyalty than customer who complaint to service which provided by phone operator. This indicated that service recovery did not enable to recover service failure.
Üstün Yetenekli Öğrencilerin Eğitiminde Görev Yapan Öğretmenlerin Bireyselleştirilmiş Eğitim Programları Hazırlamaya Uygulamaya ve İzlemeye Yönelik Görüşlerinin Değerlendirilmesi
Authors: ILİK Serife Senay 
Published: March 2019

Bu çalışmanın amacı üstün yetenekli öğrencilerin eğitimindegörev yapan öğretmenlerin Bireyselleştirilmiş Eğitim Programlarına ilişkin görüşlerini belirlemektir. Çalışma da nitel araştırma yöntemlerinden durum araştırma yaklaşımı kullanılmıştır. Çalışmanın örneklemini, Konya il merkezinde faaliyette olan Bilim Sanat Merkezleribünyesinde görev yapan toplam 22 öğretmen oluşturmaktadır. Öğretmenlerin görüşlerini belirlemek amacıyla 7 açık uçlu sorudan oluşan yarı yapılandırılmış görüşme formu kullanılmıştır. Veriler betimsel olarak analiz edilerek yüzde, frekans ve kesit alma ile sunulmuştur. Çalışma sonuçlarına göre öğretmenlerin Bireyselleştirilmiş Eğitim Programlarıkullanmadıkları sonucu elde edilmiştir. Ayrıca öğretmenlerin büyük çoğunluğu Bireyselleştirilmiş Eğitim Programlarıhazırlamanın gerekli olduğunu belirtmişlerdir. BEP hazırlama uygulama ve değerlendirme için eğitim gereksinimlerinin olduğunu belirtmiştir.
Otistik Çocuklarda Hayali Resim Çizebilme Performansının Otizm Derecesi ve Gelişim Tarama Testleri İle İlişkili Olarak İncelenmesi
Authors: SARI Oktay Taymaz 
Published: March 2019

Araştırma otistik çocuklarda hayali resim çizebilme performansının
otizm derecesi ve gelişim tarama testleri ile ilişkili olarak incelenmesi amacı
ile tasarlanmıştır. Araştırmaya, 5-8 yaş arası toplam 17 (5 kız,12 erkek) otizm
tanısı almış, Hayal ve Gerçek Ayrımı Ön
Değerlendirme Çalışması’nda tüm aşamaları (sözcükleri anlama, resim çiftlerini
ayırt etme ve resim tamamlama) doğru şekilde tamamlayan çocuklar alınmıştır.
Otistik çocuklar gerçek ve imkânsız varlıklara dair hayali resim çizme durumu
ve yaratıcı içerik puanı açısından değerlendirilmiştir. Ayrıca her çocuğa
gelişim tarama testleri olan Ankara Gelişim Tarama Envanteri (AGTE), Otizm Davranış
Kontrol Listesi (ABC), Peabody Resim Kelime Testi ve Gesell Gelişim Testi
uygulanarak, hayali resim çizme durumu ve yaratıcı içerik puanı tarama testleri
skorları açısından da incelenmiştir. Bulgularımız otistik çocukların resim
çiftlerinde imkânsız resmi tanımlama ve eksik resmi imkansız içerikle uyumlu
şekilde tamamlamayı başarmalarına rağmen, hayali imkansız resmi var olmayan bir
şeyi tasarlayıp çizme çizmede, özellikle insan figüründe büyük ölçüde başarısız
olmuşlardır. Otistik çocuklarda var olmayan bir şeyi tasarlayıp çizme çizebilme
performansı artan otizm derecesi ile azalmakta, gelişim tarama test skorları
ile doğru orantılı olarak artmaktadır. Otistik çocukların var olmayan bir şeyi
tasarlayıp çizmede yaşadıkları zorluğun hayal etme ve içsel temsil oluşturmadan
ziyade, planlama ve yürütme aşamalarında ortaya çıkabileceğine ve yaratıcılık,
kognitif ve dil gelişim düzeyi ve otizm derecesi ile potansiyel ilişkisine
işaret etmektedir.
A Crystallographic Study of Bis[S-benzyl-5-bromo-2-oxoindolin-3-ylidenemethanehydrazonthioate] DisuIfide Solvated with Dimethylsulfoxide
Authors: Abdul Manan Mohd Abdul Fatah , Mohamed Tahir Mohamed Ibrahim , Crouse Karen Anne , How Fiona Ni Foong , Watkin David J 
Published: March 2019

The crystal structure of the title compound has been determined. The compound crystallized in the triclinic space group P -1 , Z = 2, V = 1839.42(18) A3 and unit cell parameters a= 11.0460(6) A, b = 13.3180(7) A, c = 13.7321(8) A, a= 80.659(3)° , b= 69.800(3)° and g= 77.007(2)° with one disordered dimethylsulfoxide solvent molecule with the sulfur and oxygen atoms are distributed over two sites; S101/S102 [site occupancy factors: 0.6035/0.3965] and O130/O131 [site occupancy factor 0.3965/0.6035]. The C22-S21 and C19-S20 bond distances of1.779(7) A and 1.788(8) A indicate that both of the molecules are connected by the disulfide bond [S20-S21 2.055(2) A] in its thiol form. The crystal structure reveals that both of the 5-bromoisatin moieties are trans with respect to the [S21-S20 and C19-N18] and [S20-S21 and C22-N23] bonds whereas the benzyl group from the dithiocarbazate are in the cis configuration with respect to [S21-S20 and C19-S44] and [S20-S21 and C22-S36] bonds. The crystal structure is further stabilized by intermolecular hydrogen bonds of N9-H35...O16 formed between the two molecules and N28-H281...O130, N28-H281...O131 and C41-H411...O131 with the solvent molecule.
Neighbouring countries – an important segment in inbound tourism An example of the European Union member states
Authors: Borzyszkowski Jacek 
Published: March 2019

Abstract
The aim of the article is to present the significance of neighbouring countries in the structure of inbound tourism for the member countries of the European Union. In order to achieve this aim, some secondary materials presenting the volume and the structure of tourist traffic in the analysed countries have been referred to. The structure of the article allows the Author to provide a detailed analysis of the particular problems in the discussed field. Firstly, a review of scientific literature on tourist traffic and the significance of neighbouring countries for inbound tourism is provided. The next part of the text presents the countries adjacent to the European Union member states. Subsequently, the significance of these destinations is indicated, due to the data that present the structure of inbound tourism. It transpires that in most analysed countries, their neighbouring states come as a significant - and often even the most important - segment in inbound tourism. Furthermore, neighbouring countries often take the top positions on the list of the countries the citizens of which visit particular destinations most frequently. The analysis of the structure of inbound tourism in Poland in the years 2012-2016 also indicates that the neighbouring markets form the most important segment, regardless of some changes that took place during the analysed time period. Due to the review of some relevant documents, it is indicated (on the example of Poland) that neighbouring countries are often of priority significance in the assumptions and development plans for tourism, although the ranks of the particular countries can be different. On one hand, the considerations presented in the article allow the Author to evaluate the significance of neighbouring countries for inbound tourism in the particular countries; on the other hand, they indicate the necessity of including these countries into the tourism policy, along with promotion activities undertaken in the foreign markets.
Adquisición y procesamiento de la actividad eléctrica del corazón y cerebro usando FPAA
Authors: Mosquera Cerquera Vladimir , Tovar Méndez Fabio Alejandro 
Published: March 2019

Este artículo presenta la adquisición y procesamiento del la actividad eléctrica del corazón y cerebro usando el Circuito Analógico Programable FPA AAN231E04 de Anadigm. Este diseño muestra una nueva opción que sustituye la implementación de sistemas analógicos de forma tradicional en el procesamiento de la actividad eléctrica del corazón y cerebro con un mejor rendimiento, economía, bajo consumo de potencia y libre de perturbaciones. De esta manera, se da evidencia de nuevas formas de diseño analógico donde simplemente con especificar las características del circuito analógico a implementar, se obtienen datos satisfactorios y un diseño bastante simple pero efectivo.En este orden de ideas, el hardware desarrollado consume poca potencia, presenta un bajo costo y permite obtener resultados satisfactorios para el análisis de la actividad eléctrica.
Agricultura de precisión aplicada a la estimación del comportamiento hidráulico de los suelos con fines de riego y drenaje
Authors: Pachón Bejarano Rodrigo Alberto , Chavarro Jorge Ivan 
Published: March 2019

Uno de los cambios más significativos desde finales del siglo XX en el campo de la producción agrícola internacional y nacional, ha sido la aplicación de la agricultura de precisión. El presente artículo recoge la experiencia investigativa realizada en el distrito de riego el Juncal municipio de Palermo-Huila, donde se determinó el ambiente fisiográfico general de la zona a partir de fotografías aéreas e imágenes satelitales, estableciendo con base en el conocimiento preciso del medio natural actual, una grilla de muestreo Geo-referenciado de 143 puntos para la determinación y modelación de la probable variabilidad espacial de algunas propiedades físico-químicas de los suelos del distrito.
Con la aplicación del software Matemática 5.2 for student, se desarrollaron ecuaciones de gobierno a partir de los parámetros determinados en las muestras que fueron recolectadas en campo. La densidad aparente y textura fueron las variables de dominio base en la modelación utilizada para la estimación de otras propiedades de los suelos como la porosidad, infiltración, capacidad de campo y punto de marchitez permanente, que en conjunto definen la dinámica del movimiento del agua en el suelo. Se aplicó el análisis estadístico de correlación, alcance y multivariado a las variables con los software MATLAB y GS+ Geostatistics for the Environmental Sciences, determinando los índices de variación en la selección del método de krigeado para el desarrollo de los modelos digitales de terreno en el software SURFER 8.0 logrando exponer la variabilidad espacial de cada variable en el área de producción agrícola, generando la base para la planificación de labores agrícolas como riego y drenaje.