bluuebunny/crossref_metadata_2025_split huggingface dataset:
An epidemic of bladder cancer: ten cases of bladder cancer in male Japanese workers exposed to ortho-toluidine
Authors: Nakano Makiko , Omae Kazuyuki , Takebayashi Toru , Tanaka Shigeru , Koda Shigeki 
Published: May 2018

Abstract

Background
ortho-Toluidine (OT) was listed as a Group 1 carcinogen by the International Agency for Research on Cancer in 2012 based on epidemiological observations of workers co-exposed to OT and aromatic amines. From 2014 to 2017, several cases of bladder cancer (BCa) secondary to occupational exposure, primarily to OT, were detected in Japan.

Objective
To describe 10 cases of BCa in male Japanese workers exposed primarily to OT at two plants that produce organic dye and pigment intermediates.

Methods
Details of the 10 cases were obtained from company records and through a questionnaire and interview. The surrogate level of exposure to each aromatic amine was calculated as the total job-weight/month for each process for each job-year.

Results
No quantitative exposure data were available. In most cases the surrogate level of exposure to OT was higher than to other amines. All 10 cases were exposed primarily to OT and co-exposed to paratoluidine, ortho-anisidine, aniline, 2,4-xylidine or orthochloroaniline. The age range at diagnosis was 41-71 years (mean 56). The duration of OT exposure was 7-28 years (mean 16.5) . Disease latency was 16-28 years (mean 21.9) . Eight patients were smokers. The main symptom at diagnosis was hematuria (70%).

Conclusions
The characteristics of BCa cases were associated with a high surrogate level of OT exposure and a disease latency of more than 20 years from the initial OT exposure. The main route of OT exposure was likely through the skin. It is necessary to continue health examinations in these target groups.
Association between occupational clusters and allergic rhinitis in the Korean population: analysis of the Korean National Health and Nutrition Examination Survey data
Authors: Park Sungjin , Jung Pil Kyun , Choi Myungsup , Seok Hongdeok , Kim Hansol , Oh Sung-Soo , Koh Sang-Baek 
Published: May 2018

Abstract

Objectives
This study aimed to investigate the association between occupational clusters and allergic rhinitis (AR).

Methods
The study was based on data from the Korean National Health and Nutrition Examination Survey (KNHANES: 2007-2015). This study included 46,965 individuals: 20,491 men and 26,474 women. AR was defined as having been diagnosed by a physician. Occupations were classified according to occupational characteristics and skill levels into white (chief executives, senior officials, legislators, managers, professionals, and technicians), pink (clerks, clerical support workers, services and sales workers), blue (craft and related trades workers, drivers, plant and machine operators, assemblers, elementary occupation workers), and green (skilled agricultural, forestry, and fishery workers) categories. We calculated the odds ratios (ORs) and 95% confidence intervals (CIs) of AR according to the occupational clusters by using the chi-squared test and logistic regression.

Results
In the study population, 10.7% of the men and 13.5% of the women had AR. The prevalence of AR was highest among white-collar workers, followed by pink, blue, and green-collar workers. Compared to green-collar workers, among men the adjusted ORs of the blue, pink, and white-collar workers were 2.00 (95% CI 1.58-2.53), 2.46 (95% CI 1.91-3.15), and 2.78 (95% CI 2.20-3.51), respectively; and among women were 2.45 (95% CI 1.99-3.02), 2.64 (95% CI 2.15-3.25), and 3.63 (95% CI 2.96-4.47), respectively.

Conclusions
This study suggests that AR prevalence is significantly associated with occupational clusters.
Ekonometryczna analiza produktywności kapitału w krajach Unii Europejskiej
Authors: Batóg Jacek , Dmytrów Krzysztof 
Published: May 2018

The paper presents the results of an analysis of capital productivity in the member countries of the European Union in the years 2000-2014. On the basis of a one-factor production function, changes in this variable were calculated for both time series and cross-section data. This enabled the identification of regularities both in particular countries and the EU as a whole. Those regularities included the significant influence of the economic crisis which began in 2008, the attendant blow to capital productivity of capital in the Member States and the large differences in this measure in the international dimension. The paper’s conclusions can be used by investors, whose decisions are based on the analysis of returns on invested capital. More generally, they may also inform about the future directions of capital flows and, as a consequence, about changes in EU employment levels.
Analiza porównawcza sytuacji osób w wieku niemobilnym w krajach Unii Europejskiej
Authors: Załuska Urszula , Kwiatkowska-Ciotucha Dorota 
Published: May 2018

The article presents the results of research aimed at objectively assessing the situation of people of a non-mobile age in the European Union (UE 27) and comparing it with the subjective feelings of respondents from that age group. The focus was on Poland, against the background of other Member States, as well as the search for good practices. The study compared two approaches to assessing the age group. The first was based on objective data illustrating the situation in areas of particular social importance. The second approach relied on subjective assessments of the satisfaction of 50–64 year‑olds. Taxonomic methods were used. The study’s results made it possible to identify those countries that may be considered the friendliest for individuals of non-mobile age and to confront the objectively assessed and subjective perceptions of these people in each country.
Quantitative Proteomics Analysis of Sporadic Medullary Thyroid Cancer Reveals FN1 as a Potential Novel Candidate Prognostic Biomarker
Authors: Zhan Shaohua , Li Jinming , Wang Tianxiao , Ge Wei 
Published: May 2018

Abstract

Background
Sporadic medullary thyroid cancer (MTC) is a rare neuroendocrine tumor. Currently, although the diagnosis of sporadic MTC is relatively simple, the need to discover novel candidate prognostic biomarkers for sporadic MTC and investigate the underlying mechanism involved in this rare disease is urgent.

Materials and Methods
We employed tandem mass tag-based liquid chromatography-mass spectrometry to identify and analyze differentially expressed proteins (DEPs) in sporadic MTC. Western blotting was used to validate the DEPs. Immunohistochemistry was performed to investigate FN1 and RPS6KA3 in an independent set of sporadic MTC tissues. Immunohistochemical data were analyzed by different statistical methods.

Results
Three hundred eighty-eight DEPs were identified in mass spectrometry, mainly involved in the extracellular matrix, cytoskeletal remodeling, or oxidoreductase activity. Among them, THBS1, MMP9, FN1, RPS6KA3, SYT1, and carcinoembryonic antigen were successfully validated by Western blot. In addition, FN1 and RPS6KA3, enriched in extracellular matrix (ECM) remodeling and the mitogen-activated protein kinase (MAPK) signaling pathway, respectively, were investigated in an independent set of sporadic MTC tissues. Receiver-operator characteristic curve analysis showed that FN1 and RPS6KA3 can be used for discriminating sporadic MTC tumorous tissues from paired normal thyroid tissues, and the clinical biomarker calcitonin was positively correlated with FN1 and RPS6KA3 in tumorous tissues. Furthermore, the immunohistochemical scores of FN1 in tumorous tissue showed an inverse relationship with tumor classification, lymph node classification, and American Joint Committee on Cancer stage. Through univariate and multivariate analysis for progression-free survival, we also found that low FN1 expression in tumorous tissues was an independent worse prognostic factor for progression-free survival.

Conclusion
We identified that the pathophysiology of sporadic MTC involve numerous pathways, including the synaptic vesicle pathway, the MAPK signaling pathway, and the ECM remodeling pathway. Furthermore, our study also identified FN1 as novel prognostic biomarkers related to the pathophysiologic changes in sporadic MTC.
Cluster Analysis Demonstrates the Need to Individualize Care for Cancer Survivors
Authors: de Rooij Belle H. , Park Elyse R. , Perez Giselle K. , Rabin Julia , Quain Katharine M. , Dizon Don S. , Post Kathryn E. , Chinn Garrett M. , McDonough Allison L. , Jimenez Rachel B. , van de Poll-Franse Lonneke V. , Peppercorn Jeffrey 
Published: May 2018

Abstract

Background
In efforts to inform clinical screening and development of survivorship care services, we sought to characterize patterns of health care needs among cancer survivors by (a) identifying and characterizing subgroups based on self-reported health care needs and (b) assessing sociodemographic, clinical, and psychosocial factors associated with these subgroups.

Methods
We conducted a cross-sectional self-administered survey among patients presenting for routine follow-up care for early-stage cancer at our academic medical center. Latent class cluster analysis was used to identify clusters of survivors based on survivorship care needs within seven domains. Multiple logistic regression analyses were used to assess factors associated with these clusters.

Results
Among 292 respondents, the highest unmet needs were related to the domains of side effects (53%), self-care (51%), and emotional coping (43%). Our analysis identified four clusters of survivors: (a) low needs (n = 123, 42%), (b) mainly physical needs (n = 46, 16%), (c) mainly psychological needs (n = 57, 20%), and (d) both physical and psychological needs (n = 66, 23%). Compared with cluster 1, those in clusters 2, 3, and 4 were younger (p &lt; .03), those in clusters 3 and 4 had higher levels of psychological distress (p &lt; .05), and those in clusters 2 and 4 reported higher levels of fatigue (p &lt; .05).

Conclusion
Unmet needs among cancer survivors are prevalent; however, a substantial group of survivors report low or no health care needs. The wide variation in health care needs among cancer survivors suggests a need to screen all patients, followed by tailored interventions in clinical care delivery and research.

Implications for Practice
The characterization of patients as having few needs, predominantly physical needs, predominantly psychological needs, or substantial needs that are both physical and psychological provides a productive framework for clinical care of cancer survivors and to guide further research in this field. Further research is needed to define the tailored information and services appropriate for each group of patients and to define optimal screening tools to efficiently identify the needs of individuals in oncology practice.
Trifluridine/Tipiracil (TAS-102) in Refractory Metastatic Colorectal Cancer: A Multicenter Register in the Frame of the Italian Compassionate Use Program
Authors: Cremolini Chiara , Rossini Daniele , Martinelli Erika , Pietrantonio Filippo , Lonardi Sara , Noventa Silvia , Tamburini Emiliano , Frassineti Giovanni Luca , Mosconi Stefania , Nichetti Federico , Murgioni Sabina , Troiani Teresa , Borelli Beatrice , Zucchelli Gemma , Dal Maso Alessandro , Sforza Vincenzo , Masi Gianluca , Antoniotti Carlotta , Di Bartolomeo Maria , Miceli Rosalba , Ciardiello Fortunato , Falcone Alfredo 
Published: May 2018

Abstract

Background
TAS-102 is indicated for patients with metastatic colorectal cancer (mCRC) previously treated with, or not considered candidates for, available therapies. Given the complete inefficacy in half of patients, the lack of predictive factors, the palliative setting, and the financial and clinical toxicity, optimizing the cost-benefit ratio is crucial. The “ColonLife” nomogram allows an estimate of the 12-week life expectancy of patients with refractory mCRC.

Materials and Methods
We collected data from patients treated at eight Italian centers in the compassionate use program. Baseline characteristics of patients who were or were not progression free at 6 months were compared. The discriminative ability of the ColonLife nomogram was assessed. Among patients who received both TAS-102 and regorafenib, clinical outcomes of the two sequences were compared.

Results
This study included 341 patients. Six (2%) and 93 (27%) patients achieved response and disease stabilization, respectively. The median progression-free survival (PFS) was 2.4 months with an estimated 6-month PFS rate of 19%; the median overall survival (OS) was 6.2 months. An Eastern Cooperative Oncology Group performance status (ECOG PS) of 0, normal lactate dehydrogenase (LDH), and a time from the diagnosis of metastatic disease of &gt;18 months were independently associated with higher chances of a patient being progression free at 6 months. The discriminative ability of ColonLife was confirmed. Among 121 patients who received both regorafenib and TAS-102, no differences in first or second PFS or OS were reported between the two sequences.

Conclusion
One out of five patients achieves clinical benefit with TAS-102. ECOG PS, LDH, and time from diagnosis of metastatic disease may help to identify these patients. Excluding patients with very short life expectancy appears a reasonable approach.

Implications for Practice
Improving the cost-efficacy ratio of TAS-102 in metastatic colorectal cancer is needed to spare useless toxicities in a definitely palliative setting. Eastern Cooperative Oncology Group performance status, lactate dehydrogenase levels, and time from the diagnosis of metastatic disease may help to identify patients more likely to achieve benefit. Properly designed prognostic tools (i.e., the “ColonLife” nomogram) may enable excluding from further treatments patients with very limited life expectancy.
Treating Children with ASD: The Perspective of Caregivers
Authors: Breik Noor , Kuo I fan , Bugden Shawn , Moffat Michael , Alessi-Severini Silvia 
Published: May 2018

Purpose: Treatment of Autism Spectrum Disorders (ASD) is challenging. Parents/caregivers’ perspective on the effectiveness of therapies and services available to their children is important but neglected in the literature on ASD. This study investigated such perspective through questionnaire-guided interviews with a group of parents in the province of Manitoba (Canada). A secondary objective of the study was to explore how health care professionals and specifically pharmacists can assist in providing better care to children with ASD. Methods: Informed consent was obtained from all participants. Data on diagnoses and prescribed medications were collected from medical charts. Parents/caregivers completed questionnaires during interviews scheduled at their convenience. Specific questions were asked to gather caregivers/parents’ perspectives on the effectiveness of medications and non-pharmacological interventions in controlling symptoms experienced by their children. Information on access to education and health services was also assessed. Common themes were identified using thematic analysis. Results: All children attended school, 88% were males, 50% experienced eating/sleeping difficulties; 69% reported Attention Deficit Hyperactivity Disorder comorbidity. Risperidone was reported to be effective in controlling aggressive behaviours. Methylphenidate and aripiprazole were often discontinued. Melatonin and occupational therapy services were said to be very useful. Access to behavioural therapy was often limited. Parents were concerned about lack of trained professionals in schools, limited understanding of their children’s needs, and uncertainty for the future. Conclusions: Better education and awareness are necessary to help ASD children and their families. Pharmacists should explore opportunities to provide better services. This article is open to POST-PUBLICATION REVIEW. Registered readers (see “For Readers”) may comment by clicking on ABSTRACT on the issue’s contents page.
CONTRIBUIÇÕES ENVIADAS AO IASB/FASB REFERENTES À REVISÃO DO DRAFT DE RECONHECIMENTO DE RECEITAS
Authors: Tavares Márcia Ferreira Neves , Anjos Luiz Carlos Marques dos , Paulo Edilson 
Published: May 2018

Este estudo objetivou investigar como os incentivos influenciadores das contribuições das empresas enviadas ao IASB/FASB, referente à revisão do Projeto de Exposição (Revised Exposure Draft) de reconhecimento de receitas, estão relacionados com as teorias de regulação já desenvolvidas no âmbito da teoria da contabilidade. A pesquisa foi conduzida por meio de análise de conteúdo, na qual foram identificadas demandas dentro da revisão do draft e analisaram-se os argumentos que fomentaram a manifestação dos diferentes grupos de interesse. Utilizou-se uma amostra com 30 empresas privadas, representantes das regiões geográficas consideradas as mais ativas do mundo em relação ao volume de contribuições enviadas aos normatizadores. Os resultados encontrados demonstraram que existe uma forte consonância dos incentivos das empresas com a teoria da competição entre grupos de interesses, existindo também forte reclamação por parte destas no excesso de informações requeridas pelos reguladores, encontrando apoio teórico no conceito de overproduction. Muitos dos argumentos realizados pelas empresas ocorrem pelo fato dos reguladores não apresentarem uma teoria contábil subjacente a determinado procedimento operacional proposto.
PESQUISA SOBRE ESTRATÉGIA NO SETOR PÚBLICO BRASILEIRO: AVALIAÇÃO DA PRODUÇÃO CIENTÍFICA NO PERÍODO 2007 – 2011
Authors: Ferreira Vicente da Rocha Soares , Najberg Estela , Porto Rafael Barreiros , Sousa Marcos de Moraes , Barbosa Nelson Bezerra 
Published: May 2018

A estratégia empresarial tem sido bastante investigada no setor privado, mas, no setor público, não tem tido atenção semelhante; apesar de sua importância para a gestão de ambos os setores. Como as investigações existentes podem estar esparsas e abarcar outras áreas da Administração, este trabalho teve o objetivo de descrever a evolução dos estudos sobre Estratégia no Setor Público. Para tanto, fez-se uma sistematização e uma breve avaliação da produção científica sobre Estratégia no Setor Público brasileiro. Trata-se de uma pesquisa bibliométrica com dados da base Scielo Brasil no período de 2007 a 2011. Os artigos escolhidos foram publicados em periódicos A1, A2, B1, B2 e B3 da área de Administração, o que resultou no estudo de 35 trabalhos. A análise aponta para dois resultados: que se pesquisa pouco o tema Estratégia no Setor Público; e que esse setor ainda não utiliza os instrumentos fornecidos pela área de Estratégia.
Chemical Preliminary Evaluation of leaves, Peels, and Fleshs Fruit of Limau Kuit: Local Orange of South Kalimantan
Authors: Irwan Azidi , Mustikasari Kamilia , Ariyani Dahlena 
Published: May 2018

This research was conducted to know about fruit of limau kuit from South Kalimantan which includes weight, diemeter of fruit, volume of fruit juice, water content, and ash content of its flesh as well as water and ash content on leaves and fruit peel. Chemical preliminary examination includes measurement of pH of fruits juice and phytochemical screening test on leaves, fruit peel, and fruit flesh. The result is obtained with mean value as follows: weight 154,82 g, diameter offruit 68,45 mm, volume of juice water 44,60 ml, water content of fruit flesh 67,16%, water content of fruit peel 65,67%, leaf water content 65,88%, ash content 0,72%, fruit ash content 1,39%, and leaf ash content 3,32%. Measurement of pH of fruit juice without dilution; 100x; 1000x; and 10000x dilutions showing a value of 1.62; 2.08; 2.68; and 3.33, respectively. The results of the phytochemical examination on fresh samples of leaves, fruit peels, and fruit juices showed all samples giving positive (+) test results against alkaloids, saponins, steroids, triterpenoids (except negative (-) for fruit skin samples), tannins, and flavonoids (except (-) for the juice of the fruit). While the samples with the fresh-dried treatment extracted each using ethanol and n-hexane solvents showed (+) results for all sample extracts in both fresh-dried treatments, except (-) saponins in dried leaves (ethanol extract) and fruit peels fresh (n-hexane extract). Tannin test for fresh leaf (n-hexane) and flavonoid for fresh leaves (ethanol extract) and fresh fruit peel (ethanol extract) showed negative results.Keywords: Limau kuit, South Kalimantan, chemical preliminary test, phytochemical test, ethanol extract, n-hexane extract.
APLIKASI AMONIUM HIDROKSIDA SEBAGAI ZAT PENANGKAP FORMALDEHIDA PADA KAYU LAPIS INDAH
Authors: Nurhayati Lany , Kholik Jannah Deppy Akilul , Santoso Adi 
Published: May 2018

Emisi formaldehida dari produk kayu lapis seperti kayu lapis indah yang direkat dengan urea formaldehida (UF) dapat mengganggu kesehatan, terutama jika digunakan di dalam ruangan dengan ventilasi terbatas. Untuk mengurangi emisi formaldehida, dapat dilakukan dengan penambahan zat penangkap dan akan bereaksi dengan formaldehida yaitu amonium hidroksida (NH4OH). Data yang diamati dalam penelitian ini meliputi pengukuran kadar air dan emisi formaldehida berdasarkan Japanese Agriculture Standard 2014 No. Notifikasi 303 menggunakan metode desikator 24 jam. NH4OH 25 % yang ditambahkan dilakukan dengan cara disemprot sebanyak 10 mL; 20 mL dan 30 mL. Hasil penelitian menunjukkan bahwa dengan penyemprotan NH4OH 25% sebanyak 10 mL dapat menurunkan emisi formaldehida pada kayu lapis indah sebesar 50,77% bila dibandingkan dengan kontrol. Kadar air kayu lapis indah setelah dilakukan penyemprotan NH4OH berkisar antara 9,84%-10,34%.
Probabilistic green infrastructure cost calculations using a phased life cycle algorithm integrated with uncertainties
Authors: Yu Ziwen , Montalto Franco , Behr Chris 
Published: May 2018

Abstract
Green infrastructure (GI) is often considered a cost-effective approach to urban stormwater management. Though various models have been created to simulate the life cycle cost (LCC) and present value (PV) of GI investments, decision-support tools are still few. This paper introduces a probabilistic GI cost estimation algorithm built into the Low Impact Development Rapid Assessment (LIDRA) model. This algorithm tracks annual and cumulative costs associated with the construction, operation and maintenance (O&M), and ultimate replacement of GI systems. In addition, the algorithm accounts for uncertainties in cost drivers, such as a GI's useful life (until replacement), capital and annual O&M costs, inflation, and interest rates. Net present value (NPV) is used to normalize future money flows and cumulative costs of different GI investment scenarios into a comparable current year cost equivalent. Demonstrated at the block scale, the results of the LIDRA algorithm are compared to an MS Excel-based computation of average costs. Variations of uncertainties are then integrated and further explored using an alternative implementation rate. This algorithm is a way to evaluate GI costs considering physical, socioeconomic and life cycle dimensions.