bluuebunny/crossref_metadata_2025_split huggingface dataset:
Economic Community of West African States Disaster Preparedness Tabletop Exercise: Building Regional Capacity to Enhance Health Security
Authors: Morton Hamer Melinda J. , Reed Paul L. , Greulich Jane D. , Beadling Charles W. 
Published: May 2018

AbstractObjectiveThe West African Disaster Preparedness Initiative held a disaster preparedness tabletop exercise with representatives from the Economic Community of West African States (ECOWAS) in November 2015. The tabletop exercise was hosted by the Republic of Ghana’s National Disaster Management Organization and partners in Accra, Ghana.MethodsECOWAS Commission delegates and representatives from 10 member states were confronted with a series of simulated crises. Participants utilized existing national preparedness plans and web-based information technologies to research and communicate about internal disaster threats and those from neighboring countries. After each of the exercise’s three phases, facilitators distributed participant surveys.ResultsA total of 106 individuals participated in the tabletop exercise. During the exercise, national teams utilizing well-developed disaster contingency plans and emergency operations center (EOC) standard operating procedures (SOPs) reached out to help less-prepared national teams. Key issues identified in the survey were language and cultural issues as barriers, effectiveness of disaster management agencies linked to heads of state, and the need for data sharing and real-time communication for situational awareness and multisector coordination.ConclusionThis tabletop exercise helped improve and refine the ECOWAS regional and member states’ national SOPs that teams will employ to prepare for, respond to, and recover from future disasters. (Disaster Med Public Health Preparedness. 2019;13:400-404)
When domes are spandrels: on septation in turritellids (Cerithioidea) and other gastropods
Authors: Anderson Brendan M. , Allmon Warren D. 
Published: May 2018

AbstractAlthough generally considered rare in gastropods, septation has long been noted in turritellids, but functional hypotheses do not survive strong scrutiny. Here we outline a methodology for testing spandrel hypotheses and apply it to the problem of turritellid septa. We follow Gould in using “spandrel” as a term for all features that are nonadaptive sequelae of adaptive features of organisms, including those that are structurally necessary, those that are developmentally correlated, and nondeterministic by-products that are correlated to features under selection.In turritellids, septa are constructed in microstructural continuity with secondary internal thickening of the shell, are highly variable features infraspecifically, and are strongly associated with degree of shell thickening. We therefore conclude that rather than being themselves adaptive, turritellid septa are spandrels of shell thickening. Turritellid septa are composed of crossed lamellar aragonite, which appears to be constructed by mantle epithelium over the visceral mass. Septation was also found in 22 of 24 gastropod families examined from a broad phylogenetic distribution. Septa thus appear to be a widespread feature of caenogastropods, in strong contrast to previous assertions that septa are less common in modern or high-spired shells.
Local Spatial Heterogeneity of Holocene Carbon Accumulation throughout the Peat Profile of an Ombrotrophic Northern Minnesota Bog
Authors: McFarlane Karis J , Hanson Paul J , Iversen Colleen M , Phillips Jana R , Brice Deanne J 
Published: May 2018

ABSTRACTWe evaluated the spatial heterogeneity of historical carbon accumulation rates in a forested, ombrotrophic bog in Minnesota to aid understanding of responses to an ongoing decade-long warming manipulation. Eighteen peat cores indicated that the bog has been accumulating carbon for over 11,000 years, to yield 176±40 kg C m−2 to 225±58 cm of peat depth. Estimated peat basal ages ranged from 5100 to 11,100 cal BP. The long-term apparent rate of carbon accumulation over the entire peat profile was 22±2 g C m−2 yr−1. Plot location within the study area did not affect carbon accumulation rates, but estimated basal ages were younger in profiles from plots closer to the bog lagg and farther from the bog outlet. In addition, carbon accumulation varied considerably over time. Early Holocene net carbon accumulation rates were 30±6 g C m−2 yr−1. Around 3300 calendar BP, net carbon accumulation rates dropped to 15±8 g C m−2 yr−1 until the last century when net accumulation rates increased again to 74±57 g C m−2 yr−1. During this period of low accumulation, regional droughts may have lowered the water table, allowing for enhanced aerobic decomposition and making the bog more susceptible to fire. These results suggest that experimental warming treatments, as well as a future warmer climate may reduce net carbon accumulation in peat in this and other southern boreal peatlands. Furthermore, our we caution against historical interpretations extrapolated from one or a few peat cores.
Mediators and moderators of nutrition intervention effects in remote Indigenous Australia
Authors: Brimblecombe Julie , Ferguson Megan , Barzi Federica , Brown Clare , Ball Kylie 
Published: May 2018

AbstractWe conducted a longitudinal dietary intervention study to assess the impact of a store-based intervention on mediators and moderators and consequent dietary behaviour in Indigenous communities in remote Australia. We assessed dietary intake of fruit, vegetable, water and sweetened soft drink, mediators and moderators among 148, eighty-five and seventy-three adult participants (92 % women) at baseline (T1), end of intervention (T2) and at 24 weeks post intervention (T3), respectively. Mediators included perceived affordability and self-efficacy. Moderators were barriers to eat more fruit and vegetables and food security. Mixed-effects models were used to determine changes in mediators and moderators with time and associations between these and each dietary outcome. Perceived vegetable affordability increased from T1 (19 %; 95 % CI 11, 27) to T2 (38 %; 95 % CI 25, 51) (P=0·004) and returned to baseline levels at T3. High self-efficacy to eat more fruit and vegetables and to drink less soft drink decreased from T1 to T3. A reduction in soft drink intake of 27 % (95 % CI −44, −4; P=0·02) was reported at T3 compared with T1; no changes with time were observed for all other outcome measures. Regardless of time, vegetable intake was positively associated with self-efficacy to cook and try new vegetables, no barriers and food security. The dietary intervention went someway to improving perceived affordability of vegetables but was probably not strong enough to overcome other mediators and moderators constraining behaviour change. Meaningful dietary improvement in this context will be difficult to achieve without addressing underlying constraints to behaviour change.
Phosphorus absorption and gene expression levels of related transporters in the small intestine of broilers
Authors: Hu Yixin , Liao Xiudong , Wen Qian , Lu Lin , Zhang Liyang , Luo Xugang 
Published: May 2018

AbstractTo investigate the P absorption and gene expression levels of related co-transporters, type IIb sodium-dependent phosphate co-transporter (NaPi-IIb), inorganic phosphate transporter 1 (PiT-1) and inorganic phosphate transporter 2 (PiT-2) in the small intestine of broilers, 450 1-d-old Arbor Acres male broilers were randomly allocated to one of three treatments with ten replicate cages of fifteen birds per cage for each treatment in a completely randomised design. Chickens were fed a diet with no added inorganic P (containing 0·06 % non-phytate P (NPP)) or with either 0·21 or 0·44 % NPP for 21 d. Plasma P concentration in the hepatic portal vein, mRNA and protein expression levels of NaPi-IIb, PiT-1 and PiT-2 were determined at 7, 14 and 21 d of age. The results showed that the concentration of P in plasma in the hepatic portal vein increased as dietary NPP increased (P<0·0001). At 14 and 21 d of age, the increase in dietary NPP inhibited (P<0·003)NaPi-IIbmRNA expression level in the duodenum, as well as PiT-1 mRNA and protein expression levels in the ileum, but promoted NaPi-IIb protein expression level (P<0·002) and PiT-2 mRNA and protein expression levels (P<0·04) in the duodenum. These results suggest that NaPi-IIb, PiT-1 and PiT-2 might be important P transporters in the small intestine of broilers. Higher intestinal P absorption may be achieved by up-regulating the protein expression levels of NaPi-IIb and PiT-2 and down-regulating the protein expression of PiT-1.
Maternal vitamin D concentrations are associated with faster childhood reaction time and response speed, but not with motor fluency and flexibility, at the age of 5–6 years: the Amsterdam Born Children and their Development (ABCD) Study
Authors: Brouwer-Brolsma Elske M. , Vrijkotte Tanja G. M. , Feskens Edith J. M. 
Published: May 2018

AbstractAbout 57 % of the pregnant European women have 25-hydroxyvitamin D (25(OH)D) concentrations below 50 nmol/l. However, as data on the impact of gestational vitamin D deficiency on maternal and fetal health are limited, the WHO does not advocate vitamin D supplementation as part of routine antenatal care. We explored associations between first trimester maternal 25(OH)D status and childhood cognition at 5–6 years of age (n1854, primarily Caucasian). Median serum 25(OH)D was determined at 13 (interquartile range 12–14) weeks of gestation. Childhood attention, motor fluency and flexibility and executive function were assessed using the Amsterdam Neuropsychological Tasks. Restricted cubic splines and linear regression analyses were used to analyse the data while adjusting for many maternal and child related covariates. Higher 25(OH)D status (nmol/l) was associated with better attention and executive functioning as shown by a faster reaction time (β−0·30 (sd0·14) ms,P=0·03), faster response speed (β−0·58 (sd0·21) ms,P=0·006), and better response speed stability (β−0·45 (sd0·17) ms,P=0·009). No associations were observed of serum 25(OH)D with motor fluency and flexibility. Associations were most pronounced among children of African origin (n205) as compared with those of Caucasian or another origin, for example attention (reaction time,β−2·06 (sd0·70) ms,P=0·004) and executive function (response speed,β−1·95 (sd0·94) ms,P=0·04). Concluding, maternal 25(OH)D status was significantly associated with childhood attention and executive function, while no associations were observed for 25(OH)D status with motor fluency and flexibility.
IM-sgi: an interface model for shape grammar implementations
Authors: Tching Joana , Reis Joaquim , Paio Alexandra 
Published: May 2018

AbstractInformation technologies are a driving force for progress in the design field, allowing new modes of creativity. However, most of the existing computational design tools are focused on the latest stages of the design process and especially directed to drafting operations. Conceptual design tools that support the designer in the creative and inventive early stages of the design project are still in their early development. Shape grammars (SG) were introduced by George Stiny in the 1970s, allowing the generation of designs according to a set of predefined rules. SG computational implementations have the potential to answer the need for tools that can assist designers, architects, and artists in the creative process, offering design alternatives, stimulating new ideas and encouraging the search for new design generation processes. Acknowledging this potential, a user-friendly interface seems essential for the adoption of these tools. Taking Scott Chase's interaction model as background, the aim of the present investigation is to define guidelines and begin to design a graphical-user interface for SG implementations. Inspection methods of human–computer interaction (HCI) were used to analyze existing SG implementations and understand usability issues. Subsequently, HCI ergonomic criteria for interface evaluation were adapted to establish guidelines for the design of an SG implementation interface, called IM-sqi. These guidelines take into account different user groups, adjustable interaction modes for each user group, and the nature of each task performed by the user.
Molecular detection of Anaplasma phagocytophilum DNA in the lesser horseshoe bat (Rhinolophus hipposideros) guano
Authors: Afonso E. , Goydadin A.-C. 
Published: May 2018

AbstractAlthough bats are increasingly recognised as potential reservoir hosts of human zoonotic pathogens, bacteria in bats are still poorly studied. To investigate the DNA faecal prevalence of the bacterium Anaplasma phagocytophilum, we sampled 23 lesser horseshoe bat (Rhinolophus hipposideros) maternity colonies located in buildings (churches, barns) in rural villages of eastern France. A total of 552 faecal samples were collected from 278 individuals. Anaplasma phagocytophilum DNA was detected in the faeces of 63 individuals (22.7%). Such high prevalence might suggest persistent infection in bats and/or a frequent consumption of insect preys carrying bacteria. Faecal DNA prevalence varied highly among colonies but was not related to the colony size. Faecal DNA prevalence was the highest in the Jura Department, where the density of ticks is known to be the highest across the study area. Because the sampled bats live in close proximity to humans, we discuss how concerning the presence of A. phagocytophilum DNA in bat guano is for humans frequenting places of worship that shelter bats. We also advocate future research to understand what a high faecal DNA prevalence in bat guano really implicates in terms of bacteria transmission.
Positive predictive value of infective endocarditis in the Danish National Patient Registry: a validation study
Authors: Østergaard Lauge , Adelborg Kasper , Sundbøll Jens , Pedersen Lars , Loldrup Fosbøl Emil , Schmidt Morten 
Published: May 2018

AbstractThe positive predictive value of an infective endocarditis diagnosis is approximately 80% in the Danish National Patient Registry. However, since infective endocarditis is a heterogeneous disease implying long-term intravenous treatment, we hypothesiszed that the positive predictive value varies by length of hospital stay. A total of 100 patients with first-time infective endocarditis in the Danish National Patient Registry were identified from January 2010 – December 2012 at the University hospital of Aarhus and regional hospitals of Herning and Randers. Medical records were reviewed. We calculated the positive predictive value according to admission length, and separately for patients with a cardiac implantable electronic device and a prosthetic heart valve using the Wilson score method. Among the 92 medical records available for review, the majority of the patients had admission length ⩾2 weeks. The positive predictive value increased with length of admission. In patients with admission length <2 weeks the positive predictive value was 65% while it was 90% for admission length ⩾2 weeks. The positive predictive value was 81% for patients with a cardiac implantable electronic device and 87% for patients with a prosthetic valve. The positive predictive value of the infective endocarditis diagnosis in the Danish National Patient Registry is high for patients with admission length ⩾2 weeks. Using this algorithm, the Danish National Patient Registry provides a valid source for identifying infective endocarditis for research.
Regulations on Genome Editing of Human Embryos in Japan: Our Moral Moratorium
Authors: NAKAZAWA EISUKE , YAMAMOTO KEIICHIRO , AKABAYASHI ARU , AKABAYASHI AKIRA 
Published: May 2018

Abstract:The use of human embryos in genome editing research has recently been approved in China and the United Kingdom. In Japan, the debate on regulations on genome editing research studies using human embryos is underway, but is becoming increasingly entangled, to the point of deadlock. One main reason for this is the misalignment between the Japanese government and the research communities, in their awareness surrounding these regulations. In this article, we report on this ongoing and entangled debate in Japan concerning the regulations on genome editing technology using human embryos. The most critically needed next step is a grassroots level discussion among various experts such as those in the arts and humanities.
A Life Fulfilled: Should There Be Assisted Suicide for Those Who Are Done with Living?
Authors: BUIJSEN MARTIN 
Published: May 2018

Abstract:The issue of assisted suicide for those with a “fulfilled life” is being hotly debated in the Netherlands. A large number of Dutch people feel that elderly people (i.e., people who have reached the age of 70) with a “fulfilled life” should have access to assisted suicide. Citizens have therefore requested Parliament to expand the existing legislation that governs euthanasia and physician-assisted suicide. The Dutch constitution does not permit national legislation to be incompatible with higher international (human rights) law. An analysis of the case law of the European Court of Human Rights shows that a person’s right to decide on the time and manner of his or her death should be regarded as an aspect of the right to privacy. Although no positive obligation has been imposed on parties to the European Convention for the Protection of Human Rights and Fundamental Freedoms to facilitate suicide, they may do so, provided that certain conditions are met.
Quality of Living and Dying: Pediatric Palliative Care and End-of-Life Decisions in the Netherlands
Authors: BROUWER MARIJE , MAECKELBERGHE ELS , DE WEERD WILLEMIEN , VERHAGEN EDUARD 
Published: May 2018

Abstract:In 2002, The Netherlands continued its leadership in developing rules and jurisdiction regarding euthanasia and end-of-life decisions by implementing the Euthanasia Act, which allows euthanasia for patients 12 years of age and older. Subsequently, in 2005, the regulation on active ending of life for newborns was issued. However, more and more physicians and parents have stated that the age gap between these two regulations—children between 1 and 12 years old—is undesirable. These children should have the same right to end their suffering as adults and newborn infants. An extended debate on pediatric euthanasia ensued, and currently the debate is ongoing as to whether legislation should be altered in order to allow pediatric euthanasia. An emerging major question regards the active ending of life in the context of palliative care: How does a request for active ending of life relate to the care that is given to children in the palliative phase? Until now, the distinction between palliative care and end-of-life decisions continues to remain unclear, making any discussion about their mutual in- and exclusiveness hazardous at best. In this report, therefore, we aim to provide insight into the relationship between pediatric palliative care and end-of-life decisions, as understood in the Netherlands. We do so by first providing an overview of the (legal) rules and regulations regarding euthanasia and active ending of life, followed by an analysis of the relationship between these two, using the Dutch National Guidelines for Palliative Care for Children. The results of this analysis revealed two major and related features of palliative care and end-of-life decisions for children: (1) palliative care and end-of-life decisions are part of the same process, one that focuses both on quality of living and quality of dying, and (2) although physicians are seen as ultimately responsible for making end-of-life decisions, the involvement of parents and children in this decision is of the utmost importance and should be regarded as such.
Determination of Death in Execution by Lethal Injection in China
Authors: PAUL NORBERT W. , CAPLAN ARTHUR , SHAPIRO MICHAEL E. , ELS CHARL , ALLISON KIRK C. , LI HUIGE 
Published: May 2018

Abstract:Since 1997, execution in China has been increasingly performed by lethal injection. The current criteria for determination of death for execution by lethal injection (cessation of heartbeat, cessation of respiration, and dilated pupils) neither conform to current medical science nor to any standard of medical ethics. In practice, death is pronounced in China within tens of seconds after starting the lethal injection. At this stage, however, neither the common criteria for cardiopulmonary death (irreversible cessation of heartbeat and breathing) nor that of brain death (irreversible cessation of brain functions) have been met. To declare a still-living person dead is incompatible with human dignity, regardless of the processes following death pronouncement. This ethical concern is further aggravated if organs are procured from the prisoners. Analysis of postmortem blood thiopental level data from the United States indicates that thiopental, as used, may not provide sufficient surgical anesthesia. The dose of thiopental used in China is kept secret. It cannot be excluded that some of the organ explantation surgeries on prisoners subjected to lethal injection are performed under insufficient anesthesia in China. In such cases, the inmate may potentially experience asphyxiation and pain. Yet this can be easily overlooked by the medical professionals performing the explantation surgery because pancuronium prevents muscle responses to pain, resulting in an extremely inhumane situation. We call for an immediate revision of the death determination criteria in execution by lethal injection in China. Biological death must be ensured before death pronouncement, regardless of whether organ procurement is involved or not.
Dry‐Season Greening and Water Stress in Amazonia: The Role of Modeling Leaf Phenology
Authors: Manoli Gabriele , Ivanov Valeriy Y. , Fatichi Simone 
Published: May 2018

AbstractLarge uncertainties on the sensitivity of Amazon forests to drought exist. Even though water stress should suppress photosynthesis and enhance tree mortality, a green‐up has been often observed during the dry season. This interplay between climatic forcing and forest phenology is poorly understood and inadequately represented in most of existing dynamic global vegetation models calling for an improved description of the Amazon seasonal dynamics. Recent findings on tropical leaf phenology are incorporated in the state‐of‐the‐art eco‐hydrological model Thetys & Chloris. The new model accounts for a mechanistic light‐controlled leaf development, synchronized dry‐season litterfall, and an age‐dependent leaf photosynthetic capacity. Simulation results from 32 sites in the Amazon basin over a 15‐year period successfully mimic the seasonality of gross primary productivity; evapotranspiration (ET); as well as leaf area index, leaf age, and leaf productivity. Representation of tropical leaf phenology reproduces the observed dry‐season greening, reduces simulated gross primary productivity, and does not alter ET, when compared with simulations without phenology. Tolerance to dry periods, with the exception of major drought events, is simulated by the model. Deep roots rather than leaf area index regulation mechanisms control the response to short‐term droughts, but legacy effects can exacerbate multiyear water stress. Our results provide a novel mechanistic approach to model leaf phenology and flux seasonality in the tropics, reconciling the generally observed dry‐season greening, ET seasonality, and decreased carbon uptake during severe droughts.