bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of CFTR-ENaC on spinal cord edema after spinal cord injury
Authors: Shen Guowei , Zhang Yunpeng , Cheng Xinkun , Li Dongdong , Ding Zhiyong , Tian Jiwei , Chen Hui , Ding Huiming 
Published: November 2024

Abstract

Objective
To explore the role of cystic fibrosis transmembrane conduction regulator (CFTR)-Epithelial sodium channel (ENaC) in spinal cord edema after spinal cord injury (SCI) and the related mechanism.

Methods
Lipopolysaccharide (LPS)-treated M1830 astrocytes were applied as the SCI in vitro model. Immunohistochemistry, real-time PCR, and Western blotting were utilized to detect CFTR and ENaC expression. Enzyme-linked immunosorbent assay was used to measure inflammatory cytokines including TNF-α, IL-1β, IL-6, and IL-18. Transmission electron microscope examined ultrastructure changes, while CFTR-172 or Capsazepine treatment assessed their effects on edema and inflammation. Western blot analysis was employed to evaluate the PI3K, p-PI3K, AKT, and p-AKT signaling pathways in treated cells.

Results
LPS-treated M1830 cells exhibited increased levels of CFTR and pro-inflammatory cytokines, including TNF-α, IL-1β, IL-6, and IL-18, alongside decreased ENaC expression and suppressed p-PI3K/PI3K and p-AKT/AKT levels. Degeneration of the myelin sheath and axons was observed in LPS-treated M1830, while changes in ultrastructural were recovered after adding CFTR-172 or Capsazepine. The level of CFTR, TNF-α, IL-1β, IL-6, and IL-18 was decreased, while the level of ENaC, p-PI3K/PI3K, and p-AKT/AKT was increased obviously in LPS-treated M1830 with CFTR-172, Capsazepine, or IGF-1.

Conclusion
Down-regulation of CFTR and up-regulation of ENaC can attenuate inflammation in SCI by activating the PI3K/AKT signaling pathway, highlighting a new therapeutic approach for SCI treatment. These findings address a critical gap in current SCI treatments and suggest a novel intervention strategy targeting ion channel regulation.
Characteristics of induced magnetic field on the time-dependent MHD nanofluid flow through parallel plates
Authors: Sahoo Rajesh Kumar , Mishra Satya Ranjan , Alkarni Shalan , Shah Nehad Ali 
Published: November 2024

Abstract
The heat transfer characteristics of an unsteady magnetohydrodynamic flow through non-conducting infinite vertical parallel plates are presented in this investigation. The flow is subjected to an induced magnetic field, and the base fluid water contains carbon nanotubes (CNTs), in particular multi-wall carbon nanotubes, to present the behaviour of the nanofluid. The aim is to examine the effect of the applied magnetization and CNT concentration on the heat transport performance of the system. However, suitable transformation rules are adopted for the re-designing of the proposed design model into its non-dimensional form. This transformed system is then solved analytically following the standard transformations. The influence of key parameters, including the Hartmann number (Ha), the angle of inclination of the magnetic field, thermal buoyancy, heat source, and the concentration of CNTs in the nanofluid, on the flow phenomena is analysed. The consequences reveal that the occurrence of the inclined magnetic field affects the flow and heat transfer characteristics significantly. Additionally, the introduction of CNTs to the nanofluid enhances the heat transfer performance due to their unique thermal properties. The study demonstrates that enhanced Ha and CNT concentration augments the heat transfer rate.
Young Icelanders and popular culture: An empirical study of Anglicisms in conversation
Authors: Hilmisdóttir Helga 
Published: November 2024

AbstractThe aim of the study is to investigate how young Icelanders use Anglicisms in conversation that is shaped by popular culture. The data comprises 4 hours and 30 minutes of recordings: spoken interaction between two fifteen-year-old boys that are playing a computer game, and a conversation between two young women hosting a podcast on fashion, lifestyle, and entertainment. The methodological approach applied in the study is interactional linguistics. The research questions are as follows: 1) What kind of Anglicisms occur in the data in respect to parts-of-speech? 2) What interactional functions do these items have in their context? The study begins by addressing the frequency and distribution of Anglicisms in the data, but the main emphasis is on the qualitative analysis of segments of talk. The study shows that speakers use Anglicisms in a systematic and meaningful way. In the analysis, the functions were categorised as follows: Anglicisms that appear on the screen, Anglicisms that index an international identity, Anglicisms as assessments and comments, and Anglicisms in rituals such as greetings and farewells.
Nondum tecum in gratiam redii
(Suet.
Tib
. 61.5): Reconciliation and Compromise in the Tiberian Reign of Terror
Authors: Rytwo Noam 
Published: November 2024

Abstract
In an anecdote written by Suetonius to emphasize Tiberius’ extreme cruelty, the emperor is said to have been so vindictive as to not only inflict death upon multitudes of people, but also keep death from others wishing to die. These people were imprisoned and sustained by the smallest rations of food, just enough to keep them alive and suffering. When one such victim begged to be put to death, the emperor replied that he had not yet made his peace with him. Unbelievable as this anecdote may be, it raises the question of whether, and on what terms, reconciliation with this seemingly unforgiving emperor would have been possible. Most ancient authors presented Tiberius as a cruel tyrant. This is especially so in their depiction of his so-called “reign of terror” following the death of his all-powerful praetorian prefect Sejanus in 31 CE, which saw the persecution of many of the latter’s followers. Nonetheless, some notable individuals escaped the fate of their comrades. Did Tiberius simply forgive the likes of Lentulus Gaetulicus and M. Terentius for their support of Sejanus, or did he rather compromise and come to terms with them, and if so, how, and why? In this article, I argue that despite Tiberius’ traditional image and the reality of his “reign of terror”, he was perfectly capable of making pragmatic and reasonable compromises to maintain relative peace with some of Sejanus’ most powerful adherents. I will also suggest that these compromises were hardly perceived as such, not just because of the prejudice of the sources against Tiberius, but perhaps also due to a semantic and conceptual gap, which made it difficult for the ancient Romans to accept compromise as a fact.
Que signifient les « besoins des élèves » dans la littérature scientifique? Un examen de la portée.
Authors: Nadeau Sandy , Nadeau Marie-France 
Published: November 2024

L’éducation inclusive place les besoins des élèves au cœur de l’intervention éducative. Cependant, le terme besoin reste défini de manière variable selon les perspectives théoriques adoptées, fournissant peu de repères pour guider les milieux de pratique. Cette situation a pour conséquence d’entrainer une disparité et une confusion dans l’interprétation de ce qui constitue un besoin, et une incertitude quant à la façon de répondre avec équité à la diversité des besoins des élèves. Cet article vise à identifier le sens attribué aux besoins des élèves (Kaufman, 1972) dans la littérature scientifique. Au terme de l’analyse des études recensées, quatre catégories de sens se distinguent, renvoyant à un risque d’inadaptation, à un développement positif, à une tension interne propre à l’élève et à un moyen d’interventions. L’implication de ces sens sur l’éducation inclusive sera le sujet d’une discussion en vue de faire émerger des pistes de réflexion permettant de contribuer à une clarification du terme « besoins des élèves ».
ДОСЛІДЖЕННЯ ПРОЦЕСІВ МАСОВІДДАЧІ ТА ДИФУЗІЙНИХ ПРОЦЕСІВ ЦУКРОЗИ В ЧАСТИНКИ ПЛОДУ ЯБЛУКА
Authors: Гузьова Ірина О. , Атаманюк Володимир М. 
Published: November 2024

У роботі спроектовано установку для бланшування та насичення цукрозою частинок плоду яблука в режимі барботування цукрового сиропу інертним газом. Для процесу насичення підготовлено цукровий сироп з температурою 70 °С та концентрацією 60 % Brix. На основі фото зрізів бланшованих плодів визначено середній діаметр та загальну довжину каналів між клітинами бланшованого яблука, і, відповідно, поверхневу поруватість частинок – 0.162 м2/м2. Розроблено механізм процесу насичення на основі залежності швидкості насичення плодів яблука від часу. Це обгрунтовує фізичний зміст процесів насичення в зовнішньо- та внутрі-шньодифузійній областях. Доведено, що в зовнішньодифузійній області існує нерегулярне насичення на початку процесу та насичення в періоді постійної швидкості. У внутрішньодифузійній області існує період спадаючої швидкості насичення. Доведено, що ефективні коефіцієнти дифузії залежать як від гідро-динамічних умов процесу, так і від області насичення. В зовнішньодифузійній області коефіцієнт ефективної дифузії є більшим, ніж у внутрішнодифузійній, в 100–200 разів. Авторами статті запропоновано проводити процеси насичення окремо для зовнішньо- та внутрішньодифузійної області. На основі узагальнення експериментальних даних виведені аналітичні залежності зміни концентрації цукрози в частинках плодів яблука в часі для зовнішньодифузійної та внутрішньодифузійної області. Виведені залежності дають змогу теоретично розрахувати кількість цукрози, яка переходить в частинку плоду яблука у внутрішньо- та зовнішньодифузійній областях. Також виведені критеріальні рівняння для розрахування коефіцієнту масовіддачі для ламінарного, турбулентного та перехідного режимів барботування сиропу інертним газом. За допомогою критеріальних рівнянь можна визначити кількість цукрози, яка переходить з сиропу в частинку плоду яблука шляхом масовіддачі.
Measured or communicated?
Authors: Fábri György 
Published: November 2024

AbstractThis research paper explores the intricate relationship between university rankings, mass democracy, and postmodernity, elucidating the societal shift in evaluating academic excellence. As higher education experiences mass democratization, rankings emerge as vital tools in the new information market, providing accessible metrics for an increasingly diverse audience. The concept of “medialization” underscores the impact of rankings on shaping public perception, as journalists, lacking deep understanding of academic intricacies, turn to rankings for clarity. Reactivity within universities to achieve higher ranking placements underscores the internal influence of external media-driven evaluations. The paper argues that postmodern relativism challenges traditional meritocracy, disrupting the established communicative status of universities. Amidst ongoing debates about the legitimacy of rankings, the research recommends embracing a communicative meritocracy as a strategic response, emphasizing the importance of universities actively shaping their narrative. The emergence of AI, exemplified by chatGPT, is identified as a potential transformative force, offering personalized information and challenging traditional ranking methodologies. The research concludes with a call for continuous self-reflection within ranking systems and universities amidst a changing higher education landscape.
Measuring Indigenous homelessness: Findings from Our Health Counts Toronto
Authors: McConkey Stephanie , Iannace Julia , Snyder Marcie , Bourgeois Cheryllee , Smylie Janet 
Published: November 2024

Abstract
Objectives
Our Health Counts (OHC) Toronto, an Indigenous population database which addresses gaps in urban health information, was used to measure Thistle’s (2017) 12 dimensions of Indigenous homelessness. Using this framework, we examine the sociodemographic characteristics of First Nations, Inuit, and Metis (FNIM) adults living in Toronto, the 12 dimensions as experienced by this population, and the distinctions between FNIM adults who were and those who were not experiencing physical homelessness.

Methods
Respondent-driven sampling (RDS)-II proportions and 95% confidence intervals were produced from the database (n = 915 FNIM adults) to describe key sociodemographic characteristics of the population and to estimate the proportion and number of dimensions of Indigenous homelessness experienced by FNIM adults. Results were compared between those who were and those who were not living physically homeless.

Results
This study shows that 27.3% of FNIM adults in Toronto were living physically homeless. The proportion of homelessness was significantly higher among males, adults aged 26 to 54, and unemployed individuals. Using the OHC database, 7 of the 12 dimensions were measurable. Almost all FNIM adults had experienced one or more of the 7 measurable dimensions. The most common were cultural disintegration and loss, mental disruption and balance, contemporary geographic separation, and relocation and mobility. These dimensions were significantly more common among FNIM adults experiencing physical homelessness.

Conclusion
Results show that FNIM adults living physically homeless are more likely to experience other dimensions of homelessness. Using existing data, 5 of the 12 dimensions were not measurable. This points to a critical need to develop new survey tools to fully understand the historical, environmental, social, political, spiritual, and emotional factors that influence pathways into homelessness among FNIM populations.
The impact of surgical treatment of benign ovarian tumors on the reproductive health of women, taking into account the International Classification of Functioning
Authors: Zakharov I. S. , Kovlen D. V. , Bezmenko A. A. , Kondrina E. F. , Nazarenko A. A. , Trigubchuk N. А. , Shaginyan G. G. 
Published: November 2024

The article presents a systematic analysis of studies evaluating the impact of surgical treatment of benign ovarian tumors on reproductive health, taking into account the criteria stated by the International Classification of Functioning, Disability and Health. To identify articles, foreign and domestic scientific databases were used (PubMed, Cochrane, eLibrary). After the initial identification of 704 scientific publications, 46 articles were selected using inclusion and exclusion criteria.The conducted systemic analysis allows us to formulate the conclusion that surgical interventions performed for benign ovarian tumors contribute to damage to ovarian tissue, and as a result, a decrease in the ovarian reserve of patients, which is associated with impaired fertility. A number of authors have demonstrated some recovery of anti-Mullerian hormone (AMH) levels 3-12 months after surgery. A significant portion of the studies have demonstrated a more pronounced postoperative decrease in AMH rates in patients with endometriomas compared with women operated on for non-endometrioid ovarian tumors. Lower AMH rates were noted in women with bilateral surgeries for bilateral ovarian tumors compared to patients who had unilateral surgeries. The performed systemic analysis showed higher postoperative AMH rates in patients with intraoperative suture hemostasis in comparison with the use of bipolar energy; in addition, there is a relationship between the number of coagulations and the severity of the decrease in AMH rates. In a few studies, it was noted that patients who underwent surgical treatment of ovarian tumors experienced an earlier onset of menopause. In connection with these possible functional disorders, further clinical studies of a high level of evidence are needed, aimed at developing effective strategies for preserving the functioning of the reproductive system after surgical treatment of benign ovarian tumors.
Hypolipidemic and Cardioprotective Efficacy of Peltophorum pterocarpum Linn in Doxorubicin Induced Cardiotoxicity in Rats
Authors: Nithyatharani Ramalingam , Manikandan Ramasamy , Anand Arumugam Vijaya , Alhimaidi Ahmad R. , Ammari Aiman A. , Ahamed Anis 
Published: November 2024

Background: Cardiovascular disease (CVD) refers to a common group of illnesses affecting the heart and blood arteries. It encompasses heart valve problems, atherosclerosis, angina, cardiomyopathy, coronary artery disease (CAD), and infections of the heart which are considered the main causes of death. Modern medications have some success but they typically come with unfavorable side effects. Researchers are paying attention to herbal remedies because of their limited or no negative effects. This study was conducted to find out the hypolipidemic and cardioprotective potential of the ethanolic extract of Peltophorum pterocarpum (P. pterocarpum) Linn leaves in doxorubicin-induced cardiac damage in rats. Methods: The ethanolic extract of P. pterocarpum leaves was subjected to compound identification by GC-MS analysis. For in vivo analyses, the rats were divided into six groups. Cardiac damage was induced by doxorubicin at a dosage of 1.5 ml/kg b.wt. various dosages of extract (200 and 300 mg/kg b.wt.) were injected and propranolol (25 mg/kg b.wt.) is used as a standard drug. After the treatment of the extract, biochemical parameters were evaluated followed by in silico analysis. Result: The levels of cardiac marker and lysosomal enzymes significantly increased in toxin-treated rats, and the mitochondrial enzyme levels were significantly reduced. After treatment with P. pterocarpum leaf extract, the levels significantly (P less than 0.05) returned to normal. These results may prove the cardiac protective effect of the ethanolic extract of P. pterocarpum leaves in DOX-induced cardiotoxicity rats.
Sandy soil spots in northwestern Paraná: approaches for identification and quantification
Authors: Santos Leonardo José Cordeiro , Oliveira José Guilherme , Breunig Fabio Marcelo , Calegari M´árcia Regina , Berra Elias Fernando , Fidalski Jonez 
Published: November 2024

The predominance of sandy soils in the Northwest region of the state of Paraná, associated with the removal of natural vegetation, favored the development of patches of white sand on the surface without any aggregation. These spots are associated with the different types of land use existing in the region and the process of lateral soil transformation. As they constitute material without aggregation, they can be easily transported by wind and water and deposited in water bodies, causing severe environmental impacts. Thus, using thermal infrared satellite images, the objective of the present study was to map, determine the formation process of the spots and estimate the predominant particle size fractions. The model used and validated with field and laboratory information, allowed the identification of surfaces with patches of white sand present in the study region and estimating their percentage in different classes. After filtering the samples with vegetation cover during the product calculation period, an R² of 0.78 was obtained. The removal of natural vegetation has contributed to the formation and expansion of sandy patches and erosion in the northwest region of Paraná.
Gradual expansion of the indications for minimally invasive liver resection to include highly complex procedures may improve postoperative outcomes
Authors: Sawa Yui , Kawaguchi Yoshikuni , Miyata Akinori , Nishioka Yujiro , Ichida Akihiko , Akamatsu Nobuhisa , Kaneko Junichi , Hasegawa Kiyoshi 
Published: November 2024

Aim: Liver resection is performed in patients with benign and malignant liver tumors. Advancements in surgical instruments and improved perioperative management have enabled safe laparoscopic and robotic liver resections. Herein, we aimed to evaluate the patients who underwent minimally invasive liver resection (MISLR) and compare their short-term outcomes with those of patients who underwent open liver resection (OLR), according to surgical complexity.
Methods: Data of patients who underwent liver resection at our institution from January 2011 to August 2023 were obtained from a prospectively maintained database. We gradually expanded the indications for MISLR from technically less demanding procedures to intermediate- and high-complexity MISLRs. The procedures were categorized into three grades (low, intermediate, and high) according to the liver resection complexity classification.
Results: Of the 1,866 patients who underwent liver resection, 953 were included in the analysis. Of the 953 patients, 781 underwent OLR and 172 underwent MISLR. The operative time and estimated blood loss increased with the increase in surgical complexity in the MISLR group, which was similar to finding in the OLR group. The complication rate also increased with the increase in surgical complexity in the OLR group (low complexity vs. high complexity, 34.8% vs. 50.1%). However, the complication rate was steadily low and approximately 10% across all complexity grades in the MISLR group.
Conclusion: Careful selection and gradual expansion of the indications of MISLR may facilitate improved postoperative outcomes in patients undergoing highly complex MISLRs.
Initial Steps in the Development of Vaca Muerta in Agua Del Cajon Field, Within the Black Oil Play
Authors: Bodini S. A. , Alvarez Gomez E. , Tripode J. E. 
Published: November 2024

Abstract
The Vaca Muerta Formation (Weaver, 1931) represents the principal hydrocarbon-generating rock unit of the Neuquén Basin and is currently being exploited as an unconventional resource via multi-fractured horizontal wells, accounting for 58% of Argentina's oil production and 67% of its gas production. Agua del Cajon Field (ADC), situated in the southeastern region of the Neuquén Basin is a mature asset featuring over 250 vertical wells producing gas and oil from diverse geological formations. Vertical well tests to Vaca Muerta Formation have been conducted in the field over the past 10 years, where the fluid could be verified and characterized, however with non-economic production rates.
In the year 2022, using the increased availability of high technology in the basin, a horizontal well of 1500 meters of lateral length was drilled to evaluate productivity. This well was one of the first horizontal wells drilled in the Vaca Muerta Formation in the southern east basin's edge. The Pilot well showed satisfactory results, allowing to continue the development with a four well pad of 2600 m lateral length in average. The preliminary results of both Pilot well and the pad will be discussed in this paper. While the geology and drilling will be briefly described, the focus of the analysis will be the completion of the wells, wells interaction, and production results