bluuebunny/crossref_metadata_2025_split huggingface dataset:
TNAP limits TGF-β-dependent cardiac and skeletal muscle fibrosis by inactivating SMAD2/3 transcription factors
Authors: Arnò Benedetta , Galli Francesco , Roostalu Urmas , Aldeiri Bashar , Miyake Tetsuaki , Albertini Alessandra , Bragg Laricia , Prehar Sukhpal , McDermott John C. , Cartwright Elizabeth J. , Cossu Giulio 
Published: May 2019

AbstractFibrosis is associated with almost all forms of chronic cardiac and skeletal muscle diseases. The accumulation of extracellular matrix impairs the contractility of muscle cells contributing to organ failure. Transforming growth factor beta (TGF-β) plays a pivotal role in fibrosis, activating pro-fibrotic gene programs via phosphorylation of SMAD2/3 transcription factors. However, the mechanisms that control de-phosphorylation of SMAD2/3 have remained poorly characterized. Here we show that tissue non-specific alkaline phosphatase (TNAP) is highly upregulated in hypertrophic hearts and in dystrophic skeletal muscles, and the abrogation of TGF-β signalling in TNAP positive cells reduces vascular and interstitial fibrosis. We show that TNAP co-localizes and interacts with SMAD2. TNAP inhibitor MLS-0038949 increases SMAD2/3 phosphorylation, while TNAP overexpression reduces SMAD2/3 phosphorylation and the expression of downstream fibrotic genes. Overall our data demonstrate that TNAP negatively regulates TGF-β signalling and likely represents a mechanism to limit fibrosis.Summary statementThis paper shows that tissue non-specific alkaline phosphatase negatively regulates TGF-β signalling and may represent a mechanism to limit fibrosis through SMAD dephosphorylation.
Stochastic semi-supervised learning to prioritise genes from high-throughput genomic screens
Authors: Vitsios Dimitrios , Petrovski Slavé 
Published: May 2019

AbstractAccess to large-scale genomics datasets has increased the utility of hypothesis-free genome-wide analyses that result in candidate lists of genes. Often these analyses highlight several gene signals that might contribute to pathogenesis but are insufficiently powered to reach experiment-wide significance. This often triggers a process of laborious evaluation of highly-ranked genes through manual inspection of various public knowledge resources to triage those considered sufficiently interesting for deeper investigation. Here, we introduce a novel multi-dimensional, multi-step machine learning framework to objectively and more holistically assess biological relevance of genes to disease studies, by relying on a plethora of gene-associated annotations. We developed mantis-ml to serve as an automated machine learning (AutoML) framework, following a stochastic semi-supervised learning approach to rank known and novel disease-associated genes through iterative training and prediction sessions of random balanced datasets across the protein-coding exome (n=18,626 genes). We applied this framework on a range of disease-specific areas and as a generic disease likelihood estimator, achieving an average Area Under Curve (AUC) prediction performance of 0.85. Critically, to demonstrate applied utility on exome-wide association studies, we overlapped mantis-ml disease-specific predictions with data from published cohort-level association studies. We retrieved statistically significant enrichment of high mantis-ml predictions among the top-ranked genes from hypothesis-free cohort-level statistics (p<0.05), suggesting the capture of true prioritisation signals. We believe that mantis-ml is a novel easy-to-use tool to support objectively triaging gene discovery and overall enhancing our understanding of complex genotype-phenotype associations.
Chemical-state-dependent free energy profile from single-molecule trajectories of biomolecular motor: Application to processive chitinase
Authors: Okazaki Kei-ichi , Nakamura Akihiko , Iino Ryota 
Published: May 2019

ABSTRACTThe mechanism of biomolecular motors has been elucidated using single-molecule experiments for visualizing motor motion. However, it remains elusive that how changes in the chemical state during the catalytic cycle of motors lead to unidirectional motions. In this study, we use singlemolecule trajectories to estimate an underlying diffusion model with chemical-state-dependent free energy profile. To consider nonequilibrium trajectories driven by the chemical energy consumed by biomolecular motors, we develop a novel framework based on a hidden Markov model, wherein switching among multiple energy profiles occurs reflecting the chemical state changes in motors. The method is tested using simulation trajectories and applied to singlemolecule trajectories of processive chitinase, a linear motor that is driven by the hydrolysis energy of a single chitin chain. The chemical-state-dependent free energy profile underlying the burnt- bridge Brownian ratchet mechanism of processive chitinase is determined. The novel framework allows us to connect the chemical state changes to the unidirectional motion of biomolecular motors.
Impact of personality traits on information needs and seeking behavior of LIS students in Pakistan
Authors: Ahmed Shamshad , Rehman Farhat , Sheikh Arslan 
Published: May 2019

Purpose
This paper aims to identify the personality traits (agreeableness, openness to experience, extraversion, conscientiousness and neuroticism) of library and information science (LIS) students in Pakistan. The difference among the personality traits of LIS students toward their information needs and seeking behavior is also analyzed.

Design/methodology/approach
Two instruments, namely, BFI scale and a self-structured instrument were used to collect the data. Kruskal–Wallis test was applied to find out differences among the personality traits of LIS students toward their information needs and seeking behavior.

Findings
Findings of the study revealed that out of 320 respondents, 186 possessed openness to experience, while only 7 possessed extraversion personality trait. Moreover, the students having extraversion personality trait were, generally, more concerned toward information needs. On the other hand students having conscientious trait were increasingly more seekers of information. Overall, the conscientiousness was identified as the most suitable personality trait for LIS students. A significant difference was also observed among all the personality traits of LIS students.

Practical implications
The findings of this study will help in the identification of LIS individual’s personality. The library managers can use these personality traits for the selection of suitable library professionals for their libraries.

Originality/value
This study can be valuable for the induction of new library professionals and also help managers in assigning the duties based on these personality traits.
The role of cultural difference and travel motivation in event participation
Authors: Yan Nanxi , Halpenny Elizabeth 
Published: May 2019

Purpose
Using a cross-cultural perspective, the purpose of this paper is to examine the effect of cultural difference and travel motivation on event participation and how cultural difference may influence the relationship between travel motivation and event participation. The paper highlights the importance of culture in tourism research.

Design/methodology/approach
The research was conducted by using a secondary data set (n=24,692) commissioned by Destination Canada (formerly the Canadian Tourism Commission). Both descriptive statistics (e.g. frequency analysis) and inferential statistics (e.g. hierarchical regressions) were calculated.

Findings
First of all, the results indicated that travel motivations and cultural difference can impact event participation. For example, those who were more motivated by knowledge and competence (e.g. knowing history and culture) were more likely to participate in art festivals and cultural events. Also, the research recognized that Asian-Canadians were more likely to visit ethnic or religious festivals than Anglo-Canadians, whereas Asian-Canadians were less likely to attend farmers’ market in comparison with Anglo-Canadians. Last, the effect of cultural difference can moderate the relationship between travel motivation and event participation.

Originality/value
These findings emphasize that travel motivations and cultural difference are key factors to be considered for festivals’ marketing. Particularly, the moderating effect of cultural difference reinforces that the important role played by culture for effective festival marketing should not be ignored. The research also provides valuable insights for destination managers who are interested in Asian markets. Moreover, using a secondary data set prepared by the Canadian Government largely increased the results’ representativeness, trustworthiness, and generalizability.
An integrated response model for business disruption
Authors: Wilson Phillip , Klockner Karen 
Published: May 2019

Purpose
The purpose of this paper is to discuss the planning and use of an all-hazards emergency services approach to business disruption, which resulted from the hosting of the 2018 Commonwealth Games (GC2018) by Australia. It outlines how this emergency response model worked and how it can be transitioned into other operational areas.

Design/methodology/approach
Although the Commonwealth Games provided a unique opportunity for Australia to showcase its large event capability, it also highlighted the need for innovation due to business disruption for front-line emergency response agencies. The Queensland Fire and Emergency Services (QFES) was faced with the need to review the standard emergency response model and to come up with a way to maintain business as usual operational effectiveness.

Findings
An all-hazards approach to emergency response was ultimately achieved through expanded air operations (helicopters), the use of a multi-agency approach and the use of volunteers to achieve strategic risk management outcomes.

Practical implications
The practical solutions that emerged are discussed as the expanded response model and collaborative engagements to achieve risk reduction, readiness and preparation.

Originality/value
The solution to utilise an integrated emergency response methodology, including rapid and effective aerial support, reflected an all-hazards response to include deployment to road crash rescue, hazardous materials and structural fires. This business model ensured that QFES continued to meet its established “operational excellence” standards while pioneering options to address incident responses within the community wherein circumstances are considered exceptional.
The writing performance of elementary students using a digital writing application
Authors: Baker Sheila F. , Lastrapes Renée E. 
Published: May 2019

Purpose
This paper aims to investigate elementary students’ writing experiences using a digital writing application and compares the results to the findings and recommendations of a national survey on instructional practices in writing.

Design/methodology/approach
Mixed methods were used to assess the quantity and quality of P-5 public school students’ writing over time. Teacher, librarian and student perceptions and experiences were examined and compared to the results and recommendations from a national survey on writing.

Findings
This paper provides empirical insights into the use of a digital writing application in writing instruction. Findings showed the use of a digital writing application: significantly increased the quantity and improved the quality of student writing; excited and motivated students to write; extended the learning day so more time was spent on writing; and supported students of special populations. Comparison to the recommendations of the national survey showed five of seven recommendations were not met in this study.

Research limitations/implications
Because of the chosen research approach, the research results may lack generalizability. Therefore, researchers are encouraged to conduct further investigations.

Practical implications
The paper includes implications for writing instruction using digital applications for teachers, librarians and educators in pre-service teacher and school librarian preparation programs.

Originality/value
Considering limited growth in national writing scores and the transition to online writing assessments by 2019, this paper addresses the need to integrate technology into writing instruction and offers practical strategies for doing so.
Analysing recent augmented and virtual reality developments in tourism
Authors: Moro Sérgio , Rita Paulo , Ramos Pedro , Esmerado Joaquim 
Published: May 2019

PurposeVirtual reality (VR) and augmented reality (AR) are two technological breakthroughs that stimulate reality perception. Both have been applied in tourism contexts to improve tourists’ experience. This paper aims to frame both AR and VR developments during the past 15 years from a scientific perspective.Design/methodology/approachThis study adopts a text mining and topic modelling approach to analyse a total of 1,049 articles for VR and 406 for AR. The papers were selected from Scopus, with the title, abstract and keywords being extracted for the analysis. Formulated research hypotheses based on relevant publications are then evaluated to assess the current state of the broader scope of the large sets of literature.FindingsMost of research using AR is based on mobile technology. Yet, wearable devices still show few publications, a gap that is expected to close in the near future. There is a lack of research adopting Big Data/machine learning approaches based on secondary data.Originality/valueAs both AR and VR technologies are becoming more mature, more applications to tourism emerge. Scholars need to keep pace and fill in the research gaps on both domains to move research forward.
Inter-organisational knowledge networks: synthesising dialectic tensions of university-industry knowledge discovery
Authors: Dooley Lawrence , Gubbins Claire 
Published: May 2019

PurposeDespite growth in use of inter-organisational relationships for knowledge co-creation, many collaborations struggle to realise the synergistic benefits of these networks. This paper aims to explore the evolving dialectic tensions evident within an inter-organisational relationship and the governance consideration to optimise the knowledge process.Design/methodology/approachA longitudinal case of a university-industry knowledge network is selected for study. The single case analysis aligns with the dialectical epistemology, which dismisses the expectation of homogeny or constancy across network cases.FindingsThe research highlights the circular condition between dialectic tensions evident within inter-organisational relations and the governance mechanisms developed to synthesis the network knowledge discovery capability. The research shows that these tensions are a natural part of the network existence and often advantageous to knowledge creation. The research also highlights that governance is required at multiple levels within the network entity to optimise knowledge exchange and discovery.Originality/valueThe research adds to the limited application of dialectical thinking to inter-organisational networks. It highlights the structural and relational governance mechanisms that interplay to optimise their knowledge process capability. The research also highlights the multiple levels within networks at which tensions can originate, requiring knowledge governance at the micro, meso and macro level to address the complexity of the inter-organisational relationship. This research provides a better understanding of how knowledge within inter-organisational relations can be managed for mutual benefit and value creation.
Do leadership styles promote ambidextrous innovation? Case of knowledge-intensive firms
Authors: Berraies Sarra , Zine El Abidine Syrine 
Published: May 2019

PurposeThe purpose of this study is to examine the effect of the transformational and transactional leadership styles and its sub-dimensions on exploitative and exploratory innovations. The authors deepened the analysis by highlighting the contribution of ambidextrous leadership on ambidextrous innovation.Design/methodology/approachThe conceptual model defined through a thorough review of the literature is tested empirically on a sample of 265 senior managers working in Tunisian knowledge-intensive firms (KIFs). A quantitative analysis is performed via a questionnaire. The analysis of the data collected is carried out using the partial least squares method.FindingsResults show that exploratory innovation is linked to transformational leadership and in particular to individualized consideration, intellectual stimulation and inspirational motivation. Moreover, exploitative innovation is promoted by transformational and transactional leadership styles and particularly by attributed idealized influence and contingent rewards. Also, ambidextrous leadership affects positively ambidextrous innovation.Originality/valueWhile little studies have investigated how the transformational and transactional leadership styles as constructs of second-order influence differently exploitative innovation and exploratory innovation, this research deepens the analysis by focusing on sub-dimensions of leadership styles that promote each type of innovation within KIFs. It also pioneers the investigation of the effect of ambidextrous leadership on ambidextrous innovation that has never been explored. This research provides important insights for leaders of KIFs and sheds the light on the key aspects of leadership that boost ambidextrous innovation.
In search of continuity
Authors: Olejniczak Tomasz , Pikos Anna , Goto Toshio 
Published: May 2019

Purpose
This study aims to represent an early attempt to define the notion of continuity and empirically illustrate its explanatory potential and methodological challenges.

Design/methodology/approach
This study combines historical and qualitative research techniques to conduct a qualitative analysis of continuity in the Jablkowski Brothers Department Store, a Polish centennial company. The paper highlights the potential synergies between historical and qualitative methods when applied to the analysis of long periods of time.

Findings
The authors find that using a theoretical framework of continuity provides novel ontological and epistemological insights into the nature of long-lived companies. Based on the findings, the authors present continuity in the context of existing theories and argue that it is a unique concept that deserves more scientific attention and rigorous empirical study.

Originality/value
This study contributes to the existing literature in three ways. First, it provides a brief, interdisciplinary overview of the concept of continuity. Second, it provides an empirical illustration of continuity analysis in a Polish centennial company with extremely discontinuous history. Finally, it positions continuity within the wider context of existing theories and shows how, through continuity, history can contribute to both the practice and theory of management.
Understanding the effectiveness of performance management system
Authors: Kang Young Cheoul , Choi Nakbum 
Published: May 2019

Purpose
The purpose of this paper is to explore factors that can influence on the police officer’s perception of the effectiveness of the performance management system (PMS). This study examines the effect of the attitude of employees and causal relationships between organizational/individual factors and the effectiveness of PMS during the implementation process.

Design/methodology/approach
The authors conducted a nationwide online survey of 10,619 police officers in South Korea. Structural equation modeling was employed to analyze multiple relationships simultaneously. The authors constructed a baseline model and also examined an alternative model in order to increase the model’s explanatory power.

Findings
Police officers’ perception of the understanding of the PMS, manager’s concern, participation and performance information (PI) usage exerted significant effects on the perceived effectiveness of the PMS. However, the relation between understanding of the PMS and PI usage was not significant. The study identified organizational and institutional settings for the success of the PMS. Overall, results support findings of previous studies that suggest an important role of common consensus on performance indicators and agreement between managers and employees.

Research limitations/implications
While the data size of this study is quite large, it should be considered that the respondent’s preferences on the PMS might have influenced survey results. Findings are limited by the use of a cross-sectional design. Future studies may investigate changes in causal relationships over time by employing a panel design. In addition, various survey items related to the practices of the PMS within the police organization need to be included in future studies.

Practical implications
To improve the effectiveness of performance management in the police organization, decision makers and managers must emphasize behavioral aspects of the system, especially the causal relationship between practices and perception of the usefulness of the system.

Originality/value
Despite the wide use of PMS in police management practice, police officers’ perception of the effectiveness of these systems has received little attention in the field. This study indicated a causal link between the factors in the PMS and the perception of the police officers.
Green (environmental) HRM: aligning ideals with appropriate practices
Authors: Leidner Sarah , Baden Denise , Ashleigh Melanie J. 
Published: May 2019

PurposeThe purpose of this paper is to explore how Green (environmental) Human Resource Management (GHRM) policies can elicit green employee behaviours. This study explores the role of sustainability advocates, who are leaders and managers in pursuit of their firm’s environmental agenda, in the design and delivery of GHRM policies, communication, recruitment and selection, environmental training, rewards and incentives.Design/methodology/approachIn this qualitative study, eighteen semi-structured interviews with sustainability advocates in European firms were conducted and analysed.FindingsGHRM practices are not in themselves peripheral, intermediate or embedded, but shaped by contextual situations. Sustainability advocates’ intentions do not seem to match GHRM policy design, i.e. they try to elicit value-based behaviours by using self-interest-based approaches, leading to misalignments between the attitudes and behaviours policies attempt to elicit, and the type of behaviours they elicit in practice.Research limitations/implicationsThis study explores GHRM practice implementation experienced by leaders and managers. Further research on the role of the HR function and recipients of GHRM is needed.Practical implicationsPractitioners need to be aware that organisational incentives (GHRM policies) that reflect self-interest can lead to self-interest-based behaviour and may be short-lived. A careful consideration of contextual factors will inform the selection of suitable GHRM policies. Environmental training completion rates seem an unsuitable metric for senior management bonuses.Originality/valueThis paper investigates the design and implementation stage of GHRM, leading to an identification of GHRM policies as peripheral, intermediate or embedded. This creates an in-depth knowledge on the efficacy of GHRM policies and their relation to the environment.