bluuebunny/crossref_metadata_2025_split huggingface dataset:
Enhanced Anti‐inflammatory Effects of Diclofenac Delivered Orally via Polyvinylpyrrolidone K30/Silk Fibroin Nanoparticles in a Murine Model of Carrageenan‐Induced Paw Edema
Authors: Di Khanh Nguyen , Ha Phuong T. M. , Nguyen Ngoc Phuc , Nguyen Ngoc Yen , Truong Tri Cuong , Nguyen Thi Tuong Van , Truong Quoc‐Ky , Nguyen Manh Quan , Pham Duy Toan 
Published: November 2024

AbstractDiclofenac has a relatively low oral bioavailability (50–60 %) and is quickly metabolized with a half‐life of less than 1 h. Therefore, the oral therapeutic effect of diclofenac is not optimal. This research developed polyvinylpyrrolidone K30‐functionalized silk fibroin nanoparticles as an effective delivery system for diclofenac (FNPs‐PVP‐DC). The FNPs‐DC and FNPs‐PVP‐DC were formulated by two methods of adsorption and solvent exchange. Depending on the formulation factors, the obtained particles exhibited different properties of nano‐scale sizes (400–800 nm), narrow size distribution, negatively charged surfaces (−17 to −19 mV), high PVP K30 incorporation (23 %–50 %), pHpzc of ~6.6, and appropriate chemical interactions. Interestingly, particles formulated by the adsorption method showed low drug encapsulation efficiencies of <15 %, whereas the solvent exchange method yielded moderate results of ~40 %. The FNPs‐DC possessed aggregated patterns, while the FNPs‐PVP‐DC were more uniformly distributed. All formulations limited diclofenac release (<20 %) under gastric conditions and sustained its release in the intestinal environment. In in‐vivo carrageenan‐induced paw edema mice model, the FNPs‐PVP‐DC demonstrated a 20–30 % higher anti‐inflammatory effect and a faster onset of action (within 1 h) compared to pure diclofenac at the same dose (5 mg/kg). These findings suggest that FNPs‐PVP‐DC have promising potential as novel oral anti‐inflammatory products.
Isolated peripheral neuroleukemiosis mimicking Guillain‐Barré syndrome in an adolescent with relapsed B‐lymphoblastic leukemia
Authors: Edmondson Ethan , Pauli Paisley , Punia Jyotinder , Calame Daniel G. 
Published: November 2024

AbstractBackgroundNeuroleukemiosis, leukemic infiltration of the peripheral nervous system (PNS), is rare. Very few cases of isolated neuroleukemiosis, PNS leukemic infiltration without leukemia blasts in the blood or bone marrow, have been reported in pediatrics. Most cases have occurred in adults with acute myelogenous leukemia (AML) in remission who presented with peripheral neuropathy. We describe a pediatric patient presenting with isolated neuroleukemiosis mimicking Guillain‐Barré syndrome.Patient descriptionA 15‐year‐old boy presented 1 month after IVIG treatment for Guillain‐Barre syndrome with worsening ataxia and weakness. He had a past medical history of B‐cell acute lymphoblastic leukemia (B‐ALL) in remission for 8 years. Examination revealed distal greater than proximal weakness of the bilateral lower extremities, areflexia at the Achilles tendon, and 1+ patellar and upper extremity reflexes. Initial magnetic resonance imaging (MRI) of the brain and spine were normal, and lumbar puncture revealed increased protein with uninterpretable white count due to excessive red blood cells. Repeat MRI brain and spinal cord showed extensive enlargement of all nerve roots and enhancement of the cauda equina and portions of cranial nerve VII bilaterally. Repeat lumbar puncture with cytology revealed leukemic blast cells. Blasts were not detected in peripheral blood smear or by flow cytometry. Bone marrow biopsy was also free of blast cells, confirming the diagnosis of relapsed B‐ALL restricted to the nervous system.ConclusionsNeuroleukemiosis is a rare entity with typical clinical features of mono‐ or polyneuropathy. It most often occurs in adults in remission from AML. However, neuroleukemiosis should also be on the differential for pediatric patients in remission from ALL presenting with neuropathy.
A Pilot Investigation Into the Use of Teledentistry and Artificial Intelligence to Assess Dental Erosion in Competitive Swimmers
Authors: Lanzetti Jacopo , Ferrati Federica , Pavone Lorenzo , Mussano Federico 
Published: November 2024

ABSTRACTObjectiveThe aim of the study was to assess the prevalence of dental erosion in competitive swimmers using teledentistry and artificial intelligence.Materials and MethodsAn opportunistic sample of 20 competitive swimmers was recruited. The participants reported that they carried out an average of 2.40 h of training per day, 4.45 days per week. Data gathering was carried out remotely. The subjects completed a digital questionnaire and uploaded three photos of their mouth. Intraoral photographs were analyzed using the “Intact‐Tooth” application to assess dental erosion. A statistical analysis was carried out to verify a possible correlation between the collected data.ResultsThe average calculated Basic Erosive Wear Examination (BEWE) index was 13.95, and 11 subjects (55%) had a severe BEWE (≥ 14). More than 40% of the participants disagreed about having social issues related to tooth hypersensitivity. Considering only subjects with a severe total BEWE value, we have observed an indirect correlation between the degree of dental erosion and diet (Pearson coefficient r = −0.57), whereas a direct correlation was observed between dental erosion and age (r = 0.493) and between BEWE and weekly training hours (r = 0.217).ConclusionsBecause of their lifestyle, competitive swimmers can be considered at a higher risk of developing dental erosion. In this context, teledentistry and AI tools can be effectively used to intercept those at the highest risk and prevent the occurrence of conditions.SummaryDental erosion assessment in competitive swimmers using teledentistry and AI.
Prosthetic Soft Tissue Management in Esthetic Implant Restorations, Part I: Presurgical Planning, Implant Placement, and Restoration Timing. A Narrative Review
Authors: Atri Faezeh , Nokar Kimia 
Published: November 2024

ABSTRACTObjectivesThis two‐part review article delineates various techniques to enhance esthetic outcomes in anterior implant treatments. Part I concentrates on presurgical measures, case selection, implant placement, and restoration timing. Part II discusses post‐surgical steps, the temporary restoration phase, the emergence profile contour, abutment types, and impression techniques.Material and MethodsA comprehensive search was conducted using Medline/PubMed, Embase, Scopus, and the Cochrane Library. The primary keywords included were “Dental Implants,” “Dental Prosthesis, Implant‐Supported,” “Esthetics, Dental,” “Dental Impression Techniques,” and “Tissue Management.”ResultsInitially, 1472 studies were identified, from which 187 were selected based on publication year and title relevance. After removing duplicates, 84 abstracts were reviewed in full text, culminating in 59 studies being thoroughly analyzed.ConclusionsOptimal esthetics in implant restorations are attainable through meticulous treatment planning, precise surgical execution, and systematic restorative steps, ensuring predictable outcomes. Factors such as a thick gingival biotype, an intact facial bone wall, and atraumatic extraction significantly contribute to superior esthetic results. Immediate implant placement combined with immediate provisionalization provides the most predictable outcomes by supporting and maintaining soft tissue architecture. Conversely, delayed implant placement and provisionalization often require extensive manipulation of collapsed soft tissues to achieve desired esthetics.
Unravelling the environmental drivers determining the residual fraction of soybean seed
Authors: Lopez Emelí , Alvarez Prado Santiago , Rotundo José L. , Gerde José A. 
Published: November 2024

AbstractThere are three main components of soybean (Glycine max (L.) Merr.) seeds: protein, oil, and residual. The residual fraction includes soluble and insoluble carbohydrates, lignin, and minerals. Among soluble carbohydrates, the presence of raffinose family of oligosaccharides (RFOs) has poor nutritional value (i.e., raffinose and stachyose), and the inability of monogastric animals to digest them limits the potential use of soybean meal for food and feed applications. Our objective was to understand how different environmental conditions impact soybean seed quality, particularly the concentration of the residual fraction and its components. Nine commercial genotypes from three maturity groups were sown on early and late dates. The concentration of insoluble carbohydrates + lignin was positively associated with seed weight (r = 0.67) and negatively associated with the mean temperature during the seed‐filling period (R5–R7; r = −0.61). Within soluble carbohydrates, RFOs were negatively influenced by the mean temperature at the beginning of the seed‐filling period (R5–R6; r = −0.37), while sucrose concentration showed the opposite effect (r = 0.43). In contrast, precipitation exhibited a positive correlation with RFOs, whereas sucrose displayed a negative correlation (r = 0.38 and r = −0.42). This study showed that the decrease in protein concentration was related to the increase in the residual fraction of the seeds, and higher temperatures during seed‐filling period impacted the residual composition of the seeds, specifically by reducing RFO concentration.
Bismuth and Fluorine Dual‐Doping of Lithium Argyrodite toward High‐Performance All‐Solid‐State Lithium Metal Batteries
Authors: Jiang Ziling , Xiao Yujie , Li Lin , Li Siwu , Luo Qiyue , Yu Chuang 
Published: November 2024

AbstractChlorine‐rich lithium argyrodite is considered as a promising superionic conductor electrolyte, but its practical application is limited due to poor air stability and instability toward lithium metal. In this work, BiF3 is proposed as a multi‐functional dopant for electrolyte modification, and the effects on the ionic conductivity, air stability, critical current density, and electrolyte/Li metal interfacial stability are studied. The results show that the doped electrolyte Li5.54P0.98Bi0.02S4.5Cl1.44F0.06 (LPBiSClF0.06) still maintains a relatively high ionic conductivity of 5.37 mS cm−1. Additionally, the formation of BiS45− unit and LiBiS2 phase provides high air/moisture resistibility. Meanwhile, the critical current density of the Li/LPBiSClF0.06/Li cell is increased two‐fold (2.1 mA cm−2). The in‐situ formation of LiF and Li−Bi alloy at the lithium metal/electrolyte interface plays a key role in achieving high performance. As a result, the assembled LCO@LNO/LPBiSClF0.06/Li battery retains 78.4 % of its capacity after 100 cycles at 0.2C.
Recycling Solid Electrolytes from All‐Solid‐State Lithium‐Ion Batteries by Using Deep Eutectic Solvents as Green Extractants
Authors: Chen Yu , Shi Zhuojia , Zhang Xueqing , Wang Chenyang , Wang Yanlong , Niu Zihang , Zhang Yuqing , Feng Minghui 
Published: November 2024

AbstractAll‐solid‐state lithium‐ion batteries (ASSLIBs) are attracting significant attention due to their high energy density, conductivity and safety. However, they are expected to generate substantial waste in the near future, leading to resource depletion and environmental pollution. Therefore, it is crucial to achieve green, mild and safe recovery of ASSLIBs. Here, we for the first time to use green deep eutectic solvents (DESs) to effectively recover solid‐state electrolytes (SSEs) from ASSLIBs at mild temperature. Results show that Li leaching efficiency can reach up to 87.5 % with a superhigh Li/La selectivity of 1902 at a low temperature of 80 °C. Furthermore, 70 anti‐solvents are screened to recycle the dissolved SSEs from leachate and 12 anti‐solvents could precipitate SSEs from leachate at room temperature. This research opens new possibilities for recovering SSEs from ASSLIBs using the sustainable, cost‐effective and safe solvents.
Fuzzy Logic Multicriteria Decision‐Making for Broadcast Storm Resolution in Vehicular Ad Hoc Networks
Authors: Heidari Arash , Jamali Mohammad Ali Jabraeil , Navimipour Nima Jafari 
Published: November 2024

ABSTRACTIn vehicular ad hoc networks (VANETs), the challenge of broadcast storms during data transmission arises due to an exponential increase in message rebroadcasts. This problem is exacerbated by high‐speed node movements, frequent topology changes, and repetitive discontinuities within these networks, hindering the development of efficient broadcasting protocols. Addressing this gap, our study introduces a pioneering approach utilizing a novel fuzzy method based on multicriteria decision‐making (MCDM) to prioritize vehicles in selecting optimal neighbors for data broadcast. The aim of this work is to propose for VANETs a fuzzy MCDM‐based re‐broadcasting scheme (FMRBS). This method seeks to eliminate broadcast storms and raise data distribution efficiency. We choose the best vehicles for data transportation by using fuzzy logic. The FMRBS system excelled in many respects over UMB and 802.11‐Distance. It decreased end‐to‐end latency and overhead while increasing packet delivery ratio (PDR) and network performance. By efficiently optimizing data distribution inside VANETs, FMRBS lowers broadcasting traffic and network congestion.
Foraging strategy as a route for sexual size dimorphism evolution
Authors: Rocha Pedro N. , Gawryszewski Felipe M. 
Published: November 2024

AbstractFemale‐biased sexual size dimorphism stands as a widespread evolutionary pattern. Fecundity selection, favouring larger females with greater reproductive output, is a leading explanation. However, larger body sizes demand greater energy intake, potentially hindering the evolution of extreme female sizes. Thus, the evolution of more lucrative foraging tactics may allow for an increase in size. Hence, coupled with selection against larger males, fecundity selection should result in larger SSD in species with more lucrative foraging strategies. Crab spiders are sit‐and‐wait predators that hunt in several plant substrata. Species that forage on flowers or employ prey‐luring strategies likely have access to higher food intake than other species. We extracted body size measurements of 614 crab spider species from 43 genera and classified them based on their foraging strategy. Our findings show that foraging strategies that provide higher energy input (EFS) result in larger SSD. Statistical estimates indicate that females have a cephalothorax width 91% larger than males in EFS species, compared to 26% larger females than males in non‐EFS species. These differences possibly arise due to larger females and smaller males. The effects on male size reduction might result from scramble competition, whereas the increase in female size is likely due to fecundity selection. These results suggest that the shift towards more lucrative foraging strategies may have been a key event in body size and SSD evolution in crab spiders.
The Multi‐Functional Use of Large Tree Cavities by Arboreal Vertebrates in a Temperate Broadleaved Forest of Eastern Europe
Authors: Yatsiuk Yehor 
Published: November 2024

ABSTRACTTree cavities offer protected shelters and resources for arboreal vertebrates worldwide. In general, cavities with larger openings are better accessible for predators and are avoided by smaller species for breeding, but can still be attractive for occasional use. The current study explores the diversity of functional use types and species interactions at the largest available tree cavities (entrance width ≥ 10 cm) in a temperate European forest with a low number of large cavity‐breeding species. Year‐round camera observations at 9 cavities (range 0.7–3.5 years) revealed 34 visiting species of birds and mammals, including non‐cavity‐breeding species. The top predator threatening other large‐cavity users was European pine marten (Martes martes), which regularly visited each cavity year‐round, on average every 0.7 months. Tawny owl (Strix aluco) was the only species successfully breeding in cavities, arguably because of its ability to defend the nests. However, other species visited cavities at an average rate of 1.5 visits per day, making predominantly short visits (less than 30 s) interpreted as exploration, searching for food, or inspecting for the presence of owls (mobbing). Making short visits and time segregation with predators was a behavioural strategy to exploit cavities for most species. These results confirm that, similarly to other keystone structures (large arboreal nests, ground burrows, etc.), large tree cavities attract a significant part of the arboreal vertebrate community and enrich their habitats. To sustain these functions in wooded ecosystems, management should provide a surplus of available cavities and diversity of their characteristics even when the apparent number of breeding species is low.
Macroclimatic Convergence and Habitat Specialisation Shape the Mediterranean Seed Germination Syndrome
Authors: Cruz‐Tejada Diana María , Mattana Efisio , Rosbakh Sergey , Fernández‐Pascual Eduardo , Carta Angelino 
Published: November 2024

ABSTRACTEcological theory predicts that plant reproductive phenology in the Mediterranean regions is shaped by evolutionary processes driven by strong seasonality in precipitation–evaporation patterns. Thus, it can be expected that seed germination phenology has adapted to maximise recruitment during the season of highest water availability. Cold‐cued and slow germination (i.e., the ‘Mediterranean seed germination syndrome’) has been hypothesised to be an adaptation to ensure that seedling emergence occurs in autumn/early winter, extending the growing season before the subsequent unfavourable summer drought. However, this hypothesis has been tested on individual species or local studies, without a proper synthesis for the whole Mediterranean region. Here we tested, for the first time, the Mediterranean seed germination syndrome using experimental data for 459 species (11,363 records, 59 families) occurring in the Mediterranean Basin. We performed a phylogenetically informed Bayesian meta‐analysis to model the effect on germination proportions of seven key experimental cues: mean incubation temperature, alternating temperature regime, light and dormancy‐breaking treatments (scarification, warm stratification and cold stratification) and the modulating role of seed mass on seed germination. We show that species from lowland zonal habitats of the Mediterranean align with the Mediterranean germination syndrome hypothesis, with their seeds responding positively to cool, constant temperatures and negatively to light. Yet, habitat specialists (i.e., species restricted to mountains, coasts and wetlands) deviate from the syndrome, showing nearly opposite germination requirements. Seed mass further influences the germination niche and phylogenetically related species exhibit similar germination responses. Cumulatively, these results suggest that evolutionary pressures from local habitat‐related conditions override the macroclimatically imposed Mediterranean seed germination syndrome.
Strengths and limitations of using participatory science data to characterize a wildlife mass mortality event
Authors: Taylor Liam U. , Barychka Tatsiana , McKeon Seabird , Bartolotta Natasha , Avery‐Gomm Stephanie 
Published: November 2024

AbstractParticipatory science (i.e., “community science” or “citizen science”) platforms are increasingly used at every level of ecological and conservation research, including disease monitoring. Here, we used a comprehensive, ground‐truthed mortality dataset to judge how well participatory science data from iNaturalist represented the magnitude, taxonomic, temporal, and spatial patterns of waterbird mortality associated with a mass mortality event following the incursion of highly pathogenic avian influenza in eastern Canada in 2022. The iNaturalist dataset was effective at identifying species with high mortality (especially Northern Gannets, Morus bassanus), along with the time period and spatial regions with high concentrations of avian deaths. However, iNaturalist data severely underestimated the magnitude, overestimated the taxonomic breadth, and poorly represented the full geographic scope of disease‐related deaths. Our results suggest iNaturalist can be used to identify the species, timing, and location of relatively high mortality in situations where no other information is available and to supplement conventional sources of data. However, iNaturalist alone can neither quantify the magnitude nor pinpoint the mechanisms of mortality and therefore is not a viable substitute for comprehensive mortality assessments.
Protection of water resources from agricultural pressures: Embracing different knowledge domains in governance approaches
Authors: Wuijts Susanne , Graversgaard Morten , Van Den Brink Cors , Boekhold Sandra , Sundnes Frode , Farrow Luke , Surdyk Nicolas , Cvejic Rozalija , Tegner Anker Helle , Belinskij Antti , Van Rijswick Marleen 
Published: November 2024

AbstractThe remediation of nitrate and pesticide pollution from agriculture in drinking water resources has manifested itself as a complex and multifaceted challenge in Europe and in other continents. Addressing agricultural pollution in water resources requires cross‐sectoral approaches. The EU Water Framework Directive aims to build bridges among these sectors, but the often sectoral implementation by Member States prevents its potential from being fully explored. This study aims to contribute to the body of interdisciplinary knowledge on the driving forces towards water quality improvement from agricultural pollution by case study research in five European countries in an interdisciplinary setting. The cases have shown that the added value of voluntary practices is considerable for creating shared ambitions but limited for actual water quality improvement. Implementation of strategies should be supported by practical guidance and monitoring of outcomes that enables compliance testing and refines simulation models for the formulation of follow‐up actions. Dynamic interactions among the knowledge domains, for example, social‐economic context, the legal framework, and the state of the water system, help to identify necessary actions at the different stages of the policy cycle. Especially in the implementation, monitoring, evaluation, and adaptation stage of the policy cycle, there is a need for further studies in order to improve effectiveness, for example on the role of monitoring and evaluation, licensing, and the issue of scale in cross‐sectoral approaches.
Rise of a CD27− IgD− CD11c+ B cells population in kidney recipients achieving long‐term graft stability under immunosuppression
Authors: Brinas François , Sailliet Nicolas , Tilly Gaëlle , Delbos Laurence , Kerleau Clarisse , Giral Magali , Degauque Nicolas , Brouard Sophie , Danger Richard 
Published: November 2024

AbstractThe use of immunosuppressive treatment is required to prevent rejection events, even a long time after kidney transplantation despite rare recipients achieving long‐term graft stability without the need for immunosuppressive treatment, called operationally tolerant patients (TOLs). We comprehensively investigate the immune system of long‐term IS recipients (LTTs) and TOLs to highlight their shared and unique immune features. Blood immune cell phenotyping was performed by spectral cytometry. Samples from 34 individuals were analyzed, including 6 LTTs, 8 TOLs, 10 stable patients at 1 year posttransplantation (STAs), and 10 healthy volunteers. B cells differed between LTTs and TOLs with a decreased total B‐cell frequency and the acquisition of a memory phenotype in LTTs whereas a naive phenotype is maintained in TOLs. The frequencies of IgD−CD27− B cells and CD11c+ memory B cells are increased in LTTs, with an exhausted phenotype, evoked by a significant decrease in CD25 expression. These CD11c+ B cells display an exhausted phenotype similar to those found in several chronic immune diseases in which they have been shown to participate in their pathophysiology, suggesting active chronic inflammation in LTTs. Altogether, these data indicate that precautions should be taken to minimize IS use.