bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sleep patterns, global mental status and mortality risk among middle-aged urban adults
Authors: Beydoun May A , Beydoun Hind A , Georgescu Michael F , Tate Rio , Hossain Sharmin , Vieytes Christian A Maino , Gamaldo Alyssa A , Evans Michele K , Zonderman Alan B 
Published: November 2024

Background Sleep, cognition, and mortality may be interdependent. Objective We explored paths between sleep, cognition and mortality and potential interactions. Methods The study examines the relationship among sleep, global mental status, and mortality risk using data from 1364 participants from the Healthy Aging in Neighborhood of Diversity across the Life Span (HANDLS) study. We used Cox proportional hazards models and four-way decomposition models to analyze sleep patterns and global mental status. Results After a median time at risk of 8.2 years, 172 deaths occurred, with rate of 16 per 1000 person-years. A 1-unit increase in the Pittsburgh Sleep Quality Index (PSQI) global score was linked to a 7% increase in mortality risk in the reduced model, but this effect was attenuated in the full model. In both reduced and fully adjusted models, the PSQI global score and sleep quality domains interacted with global mental status, with poor sleep generally associated with mortality risk in the group with better global mental status at first-visit. In four-way decomposition models, total effects (TE) of PSQI scores on mortality risk were positive and statistically significant, while being mostly controlled direct effects. However, among women, the inverse TE of global mental status on mortality risk was partially mediated by PSQI sleep latency and the PSQI global. Conclusions Poor global mental status is associated with greater mortality risk at better sleep quality levels and vice versa. Further longitudinal studies with multiple sleep and cognitive performance repeats are needed to corroborate these findings.
A DAT1 gene and APOE ε4 interaction is associated with apathy and structural brain changes in mild cognitive impairment and Alzheimer's disease
Authors: Malik Rubina , Beaton Derek , Ahmed Juweiriya , Nho Kwangsik , Saykin Andrew J , Wang Jian , Hegele Robert A , Finger Elizabeth ,   for the Alzheimer's Disease Neuroimaging Initiative
Published: November 2024

Background Apathy in patients with Alzheimer's disease (AD) is associated with significant morbidity and is often one of the first neuropsychiatric symptoms to present in mild cognitive impairment (MCI). Apathy is associated with accelerated cognitive decline and atrophy in fronto-striatal regions of the brain. Previous work has shown a link between apathy and the APOE gene in the context of AD, as the APOE ε4 allele is already known to be associated with the onset of AD. However, other genetic associations with apathy are largely unexplored. Objective To examine whether interactions between genetic variants related to neurotransmitter systems and regional brain atrophy are associated with apathy in patients with MCI and AD. Methods In a sample of individuals with AD (n = 266), MCI (n = 518), and cognitively normal controls (n = 378), a partial least squares correspondence analysis modeled interactions between single nucleotide polymorphisms, structural whole-brain imaging variables, and apathy. Results An interaction was found between apathy, the possession of an APOE ε4 allele combined with minor homozygosity for the DAT1 (dopamine transporter 1) gene, and regional brain atrophy. This interaction was closely linked to the MCI and AD groups. Conclusions The results point to an association of a dopaminergic genetic marker and apathy in the AD continuum and may inform future design of clinical trials of apathy, as well as new treatment targets.
Acoustic and thermal performance of home furnishings made of blended cotton-jute fabrics
Authors: Mustafa Eman , Mohamed Hatem Kh. , Hashima Wael A. , Abd El-Aziz Manar Y. 
Published: November 2024

This paper aims to examine the performance of home furnishing applications such as curtains, floor coverings, blankets or pillows to be air permeable, thermal insulators or sound absorbing materials. Two types of fillers, banana fibers and mini Styrofoam balls, were used in different proportions. Plain 1/1, twill 2/2, and sateen four weave structures made of jute-cotton fabrics were implemented by 12 and 16 picks per inch. The KES-F7 Thermo Labo apparatus was used to test the thermal conductivity of fabrics, SDL ATLAS M021 A tester was used to test air permeability, and the sound absorption coefficient (SAC) was measured using the impedance tube. The effect of different number of fabric layers (1, 2 or 3), different types of fillers between two layers of fabric and an air gap between the back plate and fabric samples during the sound absorption test was investigated. Along with two sewing techniques, lockstitch and 3-thread overlock stitch, two layers of optimal sound absorbing samples were joined together to examine the effect of different fillers on fabric properties. Radar chart, ANOVA analysis and coefficient of correlation were used as statistical tools to analyse the results. It was found that the lockstitch demonstrated better sewing performance compared to 3-thread overlock stitch. For triple-layered fabric with a twill structure, increasing the air gap between the back plate of the impedance tube and the fabric sample shifted the resonance frequency from 1600 Hz (SAC 0.97) to 1000 Hz (SAC 0.97). When using banana fibers with sateen structure, the resonance frequency remained at 6300 Hz but with an improved of SAC 0.96 compared to SAC 0.93. On the other hand, combining Styrofoam balls and banana fibres as fillers with a twill structure shifted the resonance frequency from 6300 Hz (SAC 0.93) to 4000 Hz (SAC 0.93).
Common carotid artery reconstruction with superficial femoral artery: Surgical steps to use fresh in vivo arterial homograft
Authors: Sposato Francesco , Borghese Ottavia , Tshomba Yamume 
Published: November 2024

Objectives The use of homograft for vascular reconstruction is a common practice in infective setting or to prevent aneurysmal dilation over the time. The use of fresh arterial homograft is conversely rarely reported. Methods We report a case about the use of fresh arterial homograft as a substitute of carotid intra-stent stenosis. Results We describe the several steps of the procedure of a carotid stent graft explant and reconstruction with the interposition of the superficial femoral artery in a 29-year-old patient presenting with a carotid intra-stent stenosis. One-month postoperatively, the DUS showed the patency of the bypass graft. Conclusions Fresh in vivo superficial femoral artery for common carotid artery reconstruction may be considered in young patient as it provides excellent size-match, resistance to infection and low risk of aneurysmal degeneration.
Impact of bimekizumab and certolizumab pegol on efficacy, safety and osteoblastic activity in radiographic axial spondyloarthritis: results from a phase IIa, multicentre, randomised, double-blind, exploratory study with PET-CT imaging
Authors: Baraliakos Xenofon , de Jongh Jerney , Poddubnyy Denis , Zwezerijnen Gerben J. C. , Hemke Robert , Glatt Sophie , Shaw Stevan , Ionescu Lucian , el Baghdady Assem , Mann Joanne , Maguire Ralph Paul , Vaux Tom , de Peyrecave Natasha , Oortgiesen Marga , Baeten Dominique , van der Laken Conny 
Published: November 2024

Background: The efficacy and safety of bimekizumab (BKZ), an inhibitor of interleukin (IL)-17F in addition to IL-17A, has been established in axial spondyloarthritis (axSpA). Early assessment of new bone formation is possible using 18F-fluoride positron emission tomography-computerised tomography (PET-CT) imaging to quantitatively monitor osteoblastic activity. Objectives: This exploratory study, initiated before phase IIb/III studies, assessed the efficacy and safety of BKZ in patients with radiographic (r-)axSpA and its effect on new bone formation. Design: Patients were randomised 2:1 to BKZ 160 mg every 2 weeks (Q2W; Weeks 0–10) then 320 mg Q4W (Weeks 12–44), or the reference drug: certolizumab pegol (CZP) 400 mg Q2W (Weeks 0–4), then 200 mg Q2W (Weeks 6–10), 400 mg Q4W (Weeks 12–44). Methods: Primary (Axial Spondyloarthritis Disease Activity Score (ASDAS) change from baseline (CfB)) and secondary endpoints (ASDAS-ID, ASDAS-MI) were assessed at Week 12. PET-positive axSpA lesion counts and osteoblastic activity quantification (mean SUVauc) were performed at baseline and Weeks 12 and 48 in the sacroiliac joints and spine (PET-CT substudy; not powered to evaluate differences). Results: In total, 76 patients were randomised; 26/76 entered the PET-CT substudy. At Week 12, the mean ASDAS CfB with BKZ was −2.1 (CZP: −1.8); ASDAS-ID and ASDAS-MI were achieved by 23.9% (11/46) (CZP: 20.8% (5/24)) and 60.9% (28/46) (CZP: 45.8% (11/24)) patients. Across treatments, clinical efficacy was maintained or increased further at Week 48. In the PET-CT substudy, the total number of PET-positive axSpA lesions and mean SUVauc were substantially reduced from baseline at Week 12 with BKZ and CZP, with reductions maintained or further reduced at Week 48. Treatments were well tolerated with no new safety signals. Conclusion: Dual inhibition of IL-17A and IL-17F with BKZ resulted in improved clinical outcomes and reduced osteoblastic activity in patients with r-axSpA, suggesting the potential of BKZ to reduce disease activity and new bone formation within 12 weeks of treatment. CZP findings were consistent with previous data. No new safety signals were identified. Trial registration: ClinicalTrials.gov, NCT03215277 ( https://clinicaltrials.gov/study/NCT03215277 ).
Attenuating Cartilage Degeneration in a Low Mechanical Compression Rat Model Through Intra-Articular Injections of Allogeneic Bone Marrow-Derived Mesenchymal Stem Cells
Authors: Tai Chia , Ito Akira , Zhao Zixi , Kuroki Hiroshi , Aoyama Tomoki 
Published: November 2024

Objective Mechanical stimulation significantly contributes to posttraumatic osteoarthritis (PTOA), a condition that impedes patient recovery following intra-articular injury. Effective treatment options for compression-induced injuries are limited. Bone marrow-derived mesenchymal stem cell (BMSC) implantation has emerged as a potential therapeutic breakthrough for joint diseases. The aim of this study was to attenuate the progression of PTOA induced by cyclic loading and demonstrate the potential effectiveness of BMSCs in a rat model of low mechanical compression. Design Using a rat model of compression-induced articular cartilage injury, assessments were conducted 2, 4, and 8 weeks after cyclic compressive loading. The expression of matrix metallopeptidase 13, transforming growth factor-beta 3 (TGF-β3), insulin-like growth factor 1 (IGF-1), and cleaved caspase-3 was evaluated through immunohistochemistry to investigate the mechanistic aspects underlying the prevention of compression-induced injury following BMSCs treatment. Results Intra-articular injections of BMSCs significantly improved scores in the OARSI (Osteoarthritis Research Society International) Osteoarthritis Cartilage Histopathology Assessment System and Histological-Histochemical Grading System. This treatment showed positive outcomes in maintaining high relative cell density and reducing proteoglycan loss after cyclic compression-induced injury. The expression patterns of IGF-1 and TGF-β3 provide valuable insights into the presence and distribution of these growth factors in healthy and injured cartilage. Conclusions These findings highlight the efficacy of BMSCs treatment in attenuating the advancement of compression-induced injuries, albeit within a limited timeframe.
Transendoscopic laser ablation of an esophageal plasma cell tumor in a cat
Authors: Wallick Maya E , Lechner Matthew J , Bonaventura Nicole C 
Published: November 2024

Case summary A 15-year-old male castrated domestic shorthair cat was presented for acute lethargy, vomiting and hyporexia. Abdominal and thoracic radiographs revealed a caudal thoracic/esophageal soft tissue opacity with concern for an esophageal mass or an esophageal foreign body. Esophagoscopy confirmed the presence of a large, irregular, mid-esophageal mass. Laser ablation using esophagoscopy was utilized to debulk the mass. Approximately 80% of the mass was removed without complication and an esophagostomy feeding tube was placed. The cat was discharged the same day of the procedure. Histopathology and immunohistochemistry staining were consistent with a plasma cell tumor. Recheck esophagoscopy 2 weeks after the procedure revealed no evidence of regrowth and resolved clinical signs in the patient. Relevance and novel information Laser ablation of esophageal neoplasms in cats represents a novel, lower cost, minimally invasive, palliative treatment alternative to surgery. To the authors’ knowledge, this is the first published report of successful partial laser ablation treatment of a large esophageal plasma cell tumor in a cat.
Effect of telerehabilitation assessment for adults with musculoskeletal conditions on access to care beyond the COVID-19 pandemic: A retrospective case-control analysis
Authors: Elsabbagh Lina , AlQahtani Hanan , Alsultan Alanood Adil , AlDossary Haya Jassem , Alresheidi Husain , Abdelhamid Akram , Buraik Dina W 
Published: November 2024

Background Musculoskeletal (MSK) conditions are the leading cause of disability worldwide. In MSK care, access to physical therapy is a major issue. The effectiveness of telerehabilitation phone assessment in improving access to care for MSK conditions has not yet been established in Saudi Arabia. Purpose To compare the effect of using a telerehabilitation phone with face-to-face care initial assessment on access to care, number of sessions and goals achievement at discharge. Methods This is a retrospective unmatched case-control analysis of a total of 724 Epic ® Electronic Medical Records guided by the Evidence standards framework for digital health technologies. Closed referrals from January 1st, 2022, to August 4th, 2022, for adults referred to Physical Therapy for MSK conditions were included. Participants who received a phone assessment were compared to those who received face-to-face care. The t-test was used to compare the means of the lead time, days to second appointment and number of treatment sessions. Univariate logistic regression was conducted to obtain the odds ratio of the outcome factors in the phone group. Statistical significance was set at p ≤ .05. Additionally,we compared the percentage of goal achievement at discharge. Results The lead time in days was significantly lower for the phone group (3.82 ± 5.36) compared to the face-to-face group (15.65 ± 17.71) p < 0.0001. Longer lead times from referral to first appointment were less likely to be a phone appointment and more likely to be a face-to-face appointment p < 0.001. However, the time from the first to the second appointment was significantly longer for the phone group p<0.0001. There was no significant difference in the number of appointments between both groups. The majority of the patients in both groups achieved all therapy goals (over 80% for phone and over 75% for face-to-face). Conclusion Initial telerehabilitation phone assessments compared to face-to-face care were associated with improved access to care, and there was no difference in the number of therapy sessions associated with achieving treatment goals. Future research is needed to determine the clinical effectiveness of phone initial assessments in the management of musculoskeletal conditions.
Gadolinium leakage into ocular structures as a marker in stroke: A retrospective analysis of the WAKE-UP trial
Authors: Wouters Anke , Van Assche Tim , Scheldeman Lauranne , Cheng Bastian , Simonsen Claus Ziegler , Ebinger Martin , Nighoghossian Norbert , Muir Keith W , Endres Matthias , Fiebach Jochen B , Pedraza Salvador , Gerloff Christian , Thijs Vincent , Thomalla Götz , Lemmens Robin 
Published: November 2024

Introduction: Blood-brain barrier disruption in acute ischemic stroke is a well described phenomenon associated with hemorrhagic complications. The hyperintense acute reperfusion marker (HARM) represents gadolinium leakage in the cerebrospinal fluid. Gadolinium leakage into ocular structures (GLOS) might represent a dysfunction of the blood-ocular barrier. We aimed to investigate the presence of GLOS in the WAKE-UP trial and its association with HARM, hemorrhagic transformation (HT) and functional outcome. Patients and methods: Randomized patients from the WAKE-UP trial who underwent dynamic susceptibility contrast perfusion weighted imaging at baseline and fluid attenuated inversion recovery (FLAIR) imaging at both baseline and follow-up, were included. We studied the association between GLOS with baseline and outcome variables. Results: We were able to analyze the data of 192/503 (38%) randomized WAKE-UP patients. GLOS was detected in 56 (29%) cases, four times more frequently than HARM (7%). GLOS positive patients were older (73 vs 65 years; p < 0.01), had a lower glomerular infiltration rate (GFR 79.5 vs 87.2 mL/min; p = 0.01), higher white matter hyperintensity volume (15.0 vs 9.9 mL; p < 0.01), less often presented with a large vessel occlusion (27% vs 44%; p = 0.02) and HARM was more often observed (9/56 vs 4/136; p = 0.01). In multivariable analysis the presence of GLOS was not associated with HT nor poor functional outcome (modified Rankin scale 3–6). Discussion and conclusion: GLOS is a relatively common finding in acute ischemic stroke patients and is associated with older age, worse renal function, increased white matter hyperintensity burden and HARM but not with HT or functional outcome.
Enhancing Diagnostic Accuracy: Three-Dimensional Sonographic Diagnosis of Hydrosalpinx in Pelvic Inflammatory Disease
Authors: Fernandez Carlos M. , Levine Elliot M. , Tam Teresa 
Published: November 2024

Objective: The aim of this study was to assess the role of 3D transvaginal sonography (3DTVS) in diagnosing hydrosalpinx, a common manifestation of pelvic inflammatory disease (PID). The PID is a complex inflammatory condition, in patients who can present with pelvic pain, infertility, or pelvic mass. Materials and Methods: This study was designed as a retrospective case series and conducted to ascertain the potential utility of sonographic identification of hydrosalpinx. The patient data, across a series of patient cases, were analyzed to investigate the diagnostic and surgical approaches received. This case series comprised of patients with specific conditions including deeply infiltrating endometriosis (DIE), as well as the utilization of the ovarian-adnexal radiological data-reporting system (O-RADS), for ovarian malignancy diagnosis. Results: Among the 42 patients diagnosed sonographically with hydrosalpinx and enrolled in the study, 19 underwent laparoscopic surgery to confirm the diagnoses through histopathology. Comparing sonographic findings with operative outcomes, the diagnostic accuracy in this case series revealed hydrosalpinx diagnosis was accurately established in 14 cases (74%) utilizing 3DTVS. Conclusion: In this group of patient cases, the use of noninvasive 3DTVS was found to be a valuable adjunct to conventional diagnostic methods for the diagnosis of hydrosalpinx and supplemented contemporary gynecologic practice.
Differential regulation of magnesium transporters Slc41, Cnnm and Trpm6-7 in the kidney of salmonids may represent evolutionary adaptations to high salinity environments
Authors: Takvam Marius , Denker Elsa , Gharbi Naouel , Tronci Valentina , Kolarevic Jelena , Nilsen Tom Ole 
Published: November 2024

AbstractMagnesium is important for enzymatic reactions and physiological functions, and its intracellular concentration is tightly regulated. Atlantic salmon has the ability to handle large changes in environmental Mg2+ concentration when migrating between freshwater and seawater habitats, making it a relevant model to investigate Mg2+ homeostasis. Parr-smolt transformation (PST) is a life history transition which prepares the freshwater juvenile for the marine environment. The kidney is one of the key organs involved in handling higher salt load in teleosts. Though several key Mg2+ transport families (SLC41, CNNM and TRPM6-7) have recently been identified in mammals and a few fishes, the molecular bases of Mg2+ homeostasis in salmon are not known. We found that all three families are represented in the salmon genome and exhibit a clear conservation of key functional domains and residues. Present study indicates a selective retention of paralogous Mg2+ transporters from the fourth whole genome duplication round (Ss4R) and a differential regulation of these genes, which suggests neo- and/or sub-functionalization events. slc41a1-1, cnnm4a1, -4a2 and trpm7-2 are the main upregulated genes in the kidney during PST and remain high or further increase after exposure to seawater (33 ppt). By contrast, slc41a1-2, -3a, cnnm3-1, and cnnm3-2 are only upregulated after seawater exposure. In addition, slc41a1-1, -2, and trpm7-2 respond when exposed to brackish water (12 ppt), while cnnm3-1 and cnnm3-2 do not, indicating the existence of a lower salinity threshold response for these members. Finally, the response of slc41a1-1, -2 and trpm7-2 in salmon was significantly reduced or completely abolished when exposed to Mg2+-reduced brackish water, while others were not, suggesting they might be specifically regulated by Mg2+. Our results are consistent with previous findings on other euryhaline teleosts and chondrichthyan species, suggesting the existence of common adaptive strategies to thrive in high salinity environments. Concomitantly, salmonid-specific innovations, such as differential regulation and recruitment of family members not previously shown to be regulated in the kidney (Cnnm1 and Cnnm4) of other vertebrates might point to adaptions associated with their very plastic anadromous life cycle.