bluuebunny/crossref_metadata_2025_split huggingface dataset:
MOFs for Electrocatalysis: From Serendipity to Design Strategies
Authors: Aiyappa Harshitha Barike , Masa Justus , Andronescu Corina , Muhler Martin , Fischer Roland A. , Schuhmann Wolfgang 
Published: December 2018

AbstractThe rapid upsurge of metal–organic frameworks (MOFs) as well as MOF‐derived materials has stimulated profound interest to capitalize on their many potential untapped benefits in electrocatalysis for energy applications. The possibility of tuning the metal–ligand junctions of the MOF architecture opens new avenues to design robust, extended heterostructures for addressing the present‐day energy challenges. Interestingly, despite having detailed crystallographic information, it is often difficult to envisage the interplay of charge transport (electrons and ions), mass transport (pore system) together with the specific effects of the molecularly defined reaction center of MOFs for a given electrocatalytic reaction. Here, guidelines are offered for judiciously engineering the electronic structure of MOFs to deliver targeted electrocatalytic function. Some of the pivotal works on MOF‐based materials for electrocatalysis are discussed, which can be correlated to the biological models in terms of their structural resemblance and an instructive insight is provided about the “new chemistry” that can be explored based on the lessons learned from nature in combination with the theoretical understanding of the energetics of the reactions.
Rationalization of stereoselectivity in enzyme reactions
Authors: Chan H. C. Stephen , Pan Lu , Li Yi , Yuan Shuguang 
Published: December 2018

Enzymes are responsible for more than 5,000 different types of biochemical reactions. Enzymes speed up various chemical reactions in cell that would otherwise take millions of years to occur in milliseconds. The ability to discriminate between optical isomers is vital for living systems. The selective formation of only one product stereoisomer from achiral substrates is one of the most sophisticated tasks for enzymes. Because of the importance of stereoselectivity in biology, the structural and mechanistic basis underlying these phenomena has become the subject of intensive research. Enzymatic reactions provide the basis of cellular biochemistry and typically display high stereoselectivity. With the advances of enzyme engineering, in vitro evolution and, especially, computational rational design, scientists start to provide various methods and tools to manipulate the stereoselective properties of enzymes. To gain an insightful view of stereoselectivity in enzyme reactions, we present an extensive discussion on the latest progresses in this area.This article is categorized under:Structure and Mechanism > Computational Biochemistry and BiophysicsStructure and Mechanism > Reaction Mechanisms and CatalysisMolecular and Statistical Mechanics > Molecular Dynamics and Monte‐Carlo Methods
Subnetwork identification and chemical modulation for neural regeneration: A study combining network guided forest and heat diffusion model
Authors: Wang Hui , Wang Gang , Zhu Li‐Da , Xu Xuan , Diao Bo , Zhang Hong‐Yu 
Published: December 2018

BackgroundThe induction of neural regeneration is vital to the repair of spinal cord injury (SCI). While compared with peripheral nervous system (PNS), the regenerative capacity of the central nervous system (CNS) is extremely limited. This indicates that modulating the molecular pathways underlying PNS repair may lead to the discovery of potential treatment for CNS injury.MethodsBased on the gene expression profiles of dorsal root ganglion (DRG) after a sciatic nerve injury, we utilized network guided forest (NGF) to rank genes in terms of their capacity of distinguishing injured DRG from sham‐operated controls. Gene importance scores deriving from NGF were used as initial heat in a heat diffusion model (HotNet2) to infer the subnetworks underlying neural regeneration in the DRG. After potential regulators of the subnetworks were found through Connectivity Map (cMap), candidate compounds were experimentally evaluated for their capacity to regenerate the damaged neurons.ResultsGene ontology analysis of the subnetworks revealed ubiquinone biosynthetic process is crucial for neural regeneration. Moreover, almost half of the genes in these subnetworks are found to be related to neural regeneration via text mining. After screening compounds that are likely to modulate gene expressions of the subnetworks, three compounds were selected for the experiment. Of them, trichostatin A, a histone deacetylase inhibitor, was validated to enhance neurite outgrowth in vivo via an optic nerve crush mouse model.ConclusionsOur study identified subnetworks underlying neural regeneration, and validated a compound can promote neurite outgrowth by modulating these subnetworks. This work also suggests an alternative approach for drug repositioning that can be easily extended to other disease phenotypes.
Polarization, Partisan Preferences and Strategic Voting
Authors: Daoust Jean-François , Bol Damien 
Published: December 2018

AbstractIn this article, we study how polarization affects the propensity of supporters of non-viable parties to cast a strategic vote. To do so, we rely on Canadian election panel surveys from the Making Electoral Democracy Work project that were specifically designed to identify strategic voting. We find that the polarization between viable parties increases the probability of a supporter of a non-viable party casting a strategic vote, because it increases how much she likes her favourite viable party, and decreases how much she dislikes her least favourite viable party. Polarization thus increases strategic voting because it alters partisan preferences.
Paleocommunity mixing increases with marine transgression in Dinosaur Park Formation (Upper Cretaceous) vertebrate microfossil assemblages
Authors: Oreska Matthew P. J. , Carrano Matthew T. 
Published: December 2018

AbstractVertebrate microfossil assemblages in a stratigraphic sequence often yield similar assortments of taxa but at different relative abundances, potentially indicative of marginal paleocommunity changes driven by paleoenvironmental change over time. For example, stratigraphically younger assemblages in the Dinosaur Park Formation (DPF) yield proportionally more aquatic taxa, consistent with marine transgression. However, individual deposits may have received specimens from multiple source paleocommunities over time, limiting our ability to confidently identify ecologically significant, paleocommunity differences through direct assemblage comparisons. We adapted a three-source, two-tracer Bayesian mixing model to quantify proportional contributions from different source habitats to DPF microfossil assemblages. Prior information about the compositions of separate, relatively unmixed terrestrial, freshwater, and marine assemblages from the Belly River Group allowed us to define expected taxon percent abundances for the end-member habitats likely contributing specimens to the mixed deposits. We compared the mixed assemblage and end-member distributions using 21 different combinations of vertebrate taxa. Chondrichthyan, dinosaur, and amphibian occurrence patterns ultimately allowed us to parse the contributions from the potential sources to 14 of the 15 mixed assemblages. The results confirmed a significant decline in terrestrial contributions at younger DPF sites, driven primarily by increased freshwater specimen inputs—not incursions from the adjacent marine paleocommunity. A rising base level likely increased lateral channel migration and the prevalence of freshwater habitats on the landscape, factors that contributed to increased paleocommunity mixing at younger channel deposit sites. Bayesian methods can account for source-mixing bias, which may be common in assemblages associated with major paleoenvironmental changes.
Concerns about contracting HIV, knowing partners’ HIV sero-status and discussion of HIV/STI with sexual partners as determinants of uptake of HIV testing
Authors: Ajayi Anthony Idowu , Abioye Abdulazeez Olumide , Adeniyi Oladele Vincent , Akpan Wilson 
Published: December 2018

AbstractWorldwide, adolescents and young adults (aged 15–25 years) account for the highest proportion of new HIV infections, yet the uptake of HIV testing among this cohort is sub-optimal. Understanding factors that predict the uptake of HIV testing among adolescents and young adults is critical for designing effective and relevant interventions to increase testing. Drawing from the psychosocial constructs of the Health Belief Model, the study examined the effects of HIV risk perception, discussion of HIV with partners and knowing partners’ HIV status on HIV testing uptake among adolescents and young adults in two Nigerian universities. The study was conducted in 2018 and was cross-sectional in design, with a final sample of 784 male and female students selected using stratified random sampling. Adjusted and unadjusted logistic regression models were used to examine the effect of HIV risk perception, discussion of HIV with partners and knowing partners’ HIV status on HIV testing uptake. Only 50.6% of participants had ever tested for HIV with 30.7% being tested in the last year, with no significant differences by sex. After controlling for other covariates (age, sex and being sexually active), knowing partners’ HIV status, having discussed HIV with partners and being very concerned about contracting HIV were found to be significantly associated with ever being tested for HIV and recent HIV testing uptake. Uptake of HIV testing was found to be low in the study setting and fell short of the first ‘90%’ UNAIDS target. Age-appropriate strategies, targeting open communication on HIV/STIs and disclosure of sero-status between sexual partners are required to promote uptake of HIV testing among young adults and adolescents in Nigeria.
Facilitating creativity in dementia care: the co-construction of arts-based engagement
Authors: Robertson Jane M. , McCall Vikki 
Published: December 2018

AbstractThis paper seeks to understand the engagement of people with dementia in creative and arts-based activities by applying a relational model of citizenship and incorporating concepts of contextual and embodied learning from adult learning theory. A theoretically driven secondary analysis of observational and interview data focuses on the engagement of staff, volunteers and people with dementia during an arts-based intervention in a day centre and care home. The processes through which learning is co-constructed between the person with dementia, staff/volunteer facilitators and peers in the group to co-produce a creative engaged experience involves: increasing confidence for learning, facilitating social and physical connections, and affirming creative self-expression. The role of facilitator is central to the process of creative engagement to reinforce a sense of agency amongst participants and recognise people's prior experiences of learning and engagement in creative activities. People with dementia continue to learn and grow through engagement in creative activities to produce positive outcomes for the individual participants and for the care staff who observe and participate in this creativity. Facilitating creativity requires attention to lifelong experiences of learning in addition to the immediate interactional context to integrate arts-based interventions in dementia care successfully.
The Making of a “Simple Domestic:” Domestic Workers, the Supreme Court, and the Law in Postrevolutionary Mexico
Authors: Hidalgo Sara 
Published: December 2018

AbstractThis article examines the legal construction of domestic labor as an unskilled and undervalued occupation in postrevolutionary Mexico, a milieu that was otherwise renowned for an extraordinary expansion of workers’ rights. Based on the writing of legal scholars and legal disputes between domestic workers and their employers that reached Mexico's Supreme Court, the article discusses how a discourse that framed domestic labor as an occupation confined within the protective bounds of the household became an enduring legal formula to justify and reinforce the exclusion of domestics from labor protections recognized for other workers. In so doing, it shows how Supreme Court jurisprudence ultimately redefined the criteria for delimiting this large occupational category based on what was understood as its particular spatialization (the indoor household space) and its distinctive temporalization (guided by family needs instead of production demands). Designating workers who fit these criteria as “simple domestics,” the Court erased any professional specialization among them, marginalizing this overwhelmingly female workforce from other service workers, such as doormen and private drivers, who had previously been considered “domestic.”
APPROXIMATION OF THE TAIL PROBABILITIES FOR BIDIMENSIONAL RANDOMLY WEIGHTED SUMS WITH DEPENDENT COMPONENTS
Authors: Shen Xinmei , Ge Mingyue , Fu Ke-Ang 
Published: December 2018

AbstractLet $\left\{ {{\bi X}_k = {(X_{1,k},X_{2,k})}^{\top}, k \ge 1} \right\}$ be a sequence of independent and identically distributed random vectors whose components are allowed to be generally dependent with marginal distributions being from the class of extended regular variation, and let $\left\{ {{\brTheta} _k = {(\Theta _{1,k},\Theta _{2,k})}^{\top}, k \ge 1} \right\}$ be a sequence of nonnegative random vectors that is independent of $\left\{ {{\bi X}_k, k \ge 1} \right\}$. Under several mild assumptions, some simple asymptotic formulae of the tail probabilities for the bidimensional randomly weighted sums $\left( {\sum\nolimits_{k = 1}^n {\Theta _{1,k}} X_{1,k},\sum\nolimits_{k = 1}^n {\Theta _{2,k}} X_{2,k}} \right)^{\rm \top }$ and their maxima $({{\max} _{1 \le i \le n}}\sum\nolimits_{k = 1}^i {\Theta _{1,k}} X_{1,k},{{\max} _{1 \le i \le n}}\sum\nolimits_{k = 1}^i {\Theta _{2,k}} X_{2,k})^{\rm \top }$ are established. Moreover, uniformity of the estimate can be achieved under some technical moment conditions on $\left\{ {{\brTheta} _k, k \ge 1} \right\}$. Direct applications of the results to risk analysis are proposed, with two types of ruin probability for a discrete-time bidimensional risk model being evaluated.
A NOTE ON RÉNYI'S ENTROPY RATE FOR TIME-INHOMOGENEOUS MARKOV CHAINS
Authors: Li Wenxi , Wang Zhongzhi 
Published: December 2018

AbstractIn this note, we use the Perron–Frobenius theorem to obtain the Rényi's entropy rate for a time-inhomogeneous Markov chain whose transition matrices converge to a primitive matrix. As direct corollaries, we also obtain the Rényi's entropy rate for asymptotic circular Markov chain and the Rényi's divergence rate between two time-inhomogeneous Markov chains.
Association between Rift Valley fever virus seroprevalences in livestock and humans and their respective intra-cluster correlation coefficients, Tana River County, Kenya
Authors: Bett B. , Lindahl J. , Sang R. , Wainaina M. , Kairu-Wanyoike S. , Bukachi S. , Njeru I. , Karanja J. , Ontiri E. , Kariuki Njenga M. , Wright D. , Warimwe G. M. , Grace D. 
Published: December 2018

AbstractWe implemented a cross-sectional study in Tana River County, Kenya, a Rift Valley fever (RVF)-endemic area, to quantify the strength of association between RVF virus (RVFv) seroprevalences in livestock and humans, and their respective intra-cluster correlation coefficients (ICCs). The study involved 1932 livestock from 152 households and 552 humans from 170 households. Serum samples were collected and screened for anti-RVFv immunoglobulin G (IgG) antibodies using inhibition IgG enzyme-linked immunosorbent assay (ELISA). Data collected were analysed using generalised linear mixed effects models, with herd/household and village being fitted as random variables. The overall RVFv seroprevalences in livestock and humans were 25.41% (95% confidence interval (CI) 23.49–27.42%) and 21.20% (17.86–24.85%), respectively. The presence of at least one seropositive animal in a household was associated with an increased odds of exposure in people of 2.23 (95% CI 1.03–4.84). The ICCs associated with RVF virus seroprevalence in livestock were 0.30 (95% CI 0.19–0.44) and 0.22 (95% CI 0.12–0.38) within and between herds, respectively. These findings suggest that there is a greater variability of RVF virus exposure between than within herds. We discuss ways of using these ICC estimates in observational surveys for RVF in endemic areas and postulate that the design of the sentinel herd surveillance should consider patterns of RVF clustering to enhance its effectiveness as an early warning system for RVF epidemics.
Characterization of first blastomeres in Patagonian blenny (Eleginops maclovinus) (Perciformes: Eleginopidae)
Authors: Isler Iván Valdebenito , Figueroa Villalobos Elías , Sandoval Leydy , Contreras Mellado Pablo , Sánchez Caamaño Juan Carlos , Avendaño Jorge Farías , Risopatrón Jennie 
Published: December 2018

SummaryThere is no information about the characteristics of early cleavage in the Patagonian blennie (Eleginops maclovinus), which can be used as a diagnostic tool for embryo quality. The purpose of this investigation, therefore, was to characterize the first blastomeres of E. maclovinus morphologically. Of a ‘pool’ of incubated eggs at 10.7 ± 0.5°C, 100 microphotographs of blastodiscs were extracted at different incubation periods from 0.25 to 5 h after fertilization and analyzed. Blastodiscs taken at 3.5, 4.0 and 5.0 h were characterized and classified into symmetric or asymmetric groups according to their morphology. The proportions of length (L) and width (W) of each blastomere were determined to establish its symmetry. Additionally, 20 microphotographs of blastodiscs of normal appearance were analyzed morphologically (control blastodisc: CB) and compared other blastodiscs (4.0 and 5.0 h). The results showed that before fertilization oocytes presented a somehow turgid aspect (maximum average diameter of 987 ± 41 µm) and after fertilization and hydration, their diameter increased to 1001.5 ± 11 µm (but not statistically significant) and presented a spherical shape. First cleavage ends after 3.5 h of development, forming two blastomeres 467 ± 45 μm length (L) and 328 ± 21 μm width (W) with a L/W ratio of 1.43 ± 0.19. The second cleavage ends after development at 4.5 h forming four blastomeres 238 ± 65 μm length and 227 ± 65 μm width with a ratio L/W of 1.06 ± 0.09. Five categories were identified during the blastomere characterization: 70% normal or symmetric; 8% with odd numbers of blastomeres; 6% unequal; 6% ‘pie shaped’ and 10% amorphous.
Comparison of national cross-sectional breast-feeding surveys by maternal education in Europe (2006–2016)
Authors: Sarki Mahesh , Parlesak Alexandr , Robertson Aileen 
Published: December 2018

AbstractObjectiveBreast-feeding is an important determinant of health of mothers and their offspring. The present study aimed to compare breast-feeding rates across Europe disaggregated by maternal education and establish what proportion achieves at least 50 % exclusive breast-feeding (EBF) at 6 months.Design/SettingSecondary analysis of national or sub-national studies’ breast-feeding data for EU Member States plus Norway and Iceland, published in 2006–2016. Nineteen EU Member States plus Norway reported rates of EBF and any breast-feeding disaggregated by maternal education, of which only thirteen could be matched to the International Standard Classification of Education.ParticipantsMothers and their infants aged 0–12 months.ResultsData on EBF rates at 6 and 4 months were found in only four and six countries, respectively. At 6 months, EBF rates of 49 % in Slovakia and 44 % in Hungary were closest to WHO’s target of at least 50 % EBF. At 4 months, mothers with high education level in Denmark, the Netherlands and Germany had the highest EBF rates (71, 52 and 50 %, respectively). Mothers with low education level were less likely to initiate breast-feeding and cessation occurred early. The inequality gap ranged from 63 % in Irish mothers to no gap or very low levels of inequality in Poland, Sweden and Norway.ConclusionsMore mothers with high, compared with low, education initiate breast-feeding and practise EBF for longer. More European policies should be targeted to protect, support and promote breast-feeding, especially among mothers with only mandatory education.
Effects of folic acid food fortification scenarios on the folate intake of a multi-ethnic pregnant population
Authors: Teixeira Juliana A , Castro Teresa G , Wall Clare R , Marchioni Dirce Maria , Berry Sarah , Morton Susan MB , Grant Cameron C 
Published: December 2018

AbstractObjectiveTo simulate effects of different scenarios of folic acid fortification of food on dietary folate equivalents (DFE) intake in an ethnically diverse sample of pregnant women.DesignA forty-four-item FFQ was used to evaluate dietary intake of the population. DFE intakes were estimated for different scenarios of food fortification with folic acid: (i) voluntary fortification; (ii) increased voluntary fortification; (iii) simulated bread mandatory fortification; and (iv) simulated grains-and-rice mandatory fortification.SettingEthnically and socio-economically diverse cohort of pregnant women in New Zealand.ParticipantsPregnant women (n 5664) whose children were born in 2009–2010.ResultsParticipants identified their ethnicity as European (56·0 %), Asian (14·2 %), Māori (13·2 %), Pacific (12·8 %) or Others (3·8 %). Bread, breakfast cereals and yeast spread were main food sources of DFE in the two voluntary fortification scenarios. However, for Asian women, green leafy vegetables, bread and breakfast cereals were main contributors of DFE in these scenarios. In descending order, proportions of different ethnic groups in the lowest tertile of DFE intake for the four fortification scenarios were: Asian (39–60 %), Others (41–44 %), European (31–37 %), Pacific (23–26 %) and Māori (23–27 %). In comparisons within each ethnic group across scenarios of food fortification with folic acid, differences were observed only with DFE intake higher in the simulated grains-and-rice mandatory fortification v. other scenarios.ConclusionsIf grain and rice fortification with folic acid was mandatory in New Zealand, DFE intakes would be more evenly distributed among pregnant women of different ethnicities, potentially reducing ethnic group differences in risk of lower folate intakes.
Politics, markets, and rare commodities: responses to Chinese rare earth policy
Authors: Vekasi Kristin 
Published: December 2018

AbstractThis paper examines economic statecraft in the case of rare-earth elements, of which China controls over 90% of the world's current supply, and famously cut off exports to Japan during a territorial dispute in 2010. The rare-earth sanctions provide an opportunity to investigate claims of economic statecraft, power and interdependence, and the political implications of near-monopoly control of a resource critical for high-tech military, consumer, medical, and environmental industries. A vector error correction model statistically disentangles the effects of China's economic statecraft from their rare-earth quota and pricing policies. Prior to the sanctions, there was little international supply diversification. China's purported use of rare-earth elements was an economically costly diplomatic signal that demonstrated their potential leverage, but also had unintended consequences, as Japan moved to diversify rare-earth supplies and in doing so deepened diplomatic ties with China's neighbors. Economic statecraft served to heighten regional tensions and undermine the China's own end goals.