bluuebunny/crossref_metadata_2025_split huggingface dataset:
Germinated brown rice combined with Lactobacillus acidophilus and Bifidobacterium animalis subsp. lactis inhibits colorectal carcinogenesis in rats
Authors: Lin Pao‐Ying , Li Sing‐Chung , Lin Hui‐Pu , Shih Chun‐Kuang 
Published: November 2018

AbstractColorectal cancer is a common cancer strongly associated with diet. Certain probiotics and prebiotics possess an inhibitory activity against colorectal cancer, while synbiotics may be more effective in preventing this cancer than either prebiotics or probiotics alone. Germinated brown rice (GBR) is considered as a candidate prebiotics with anticancer potential. However, the effect of GBR combined with probiotics on colorectal cancer is not clear. The present study investigated the preventive effect of combination of GBR and Lactobacillus acidophilus, Bifidobacterium animalis subsp. lactis, or both on colorectal carcinogenesis and the possible mechanism in rats treated with 1,2‐dimethylhydrazine (DMH) and dextran sulfate sodium (DSS). DMH/DSS treatment induced preneoplastic aberrant crypt foci (ACF) and mucin‐depleted foci (MDF), reduced superoxide dismutase (SOD) activity, increased anti‐apoptotic Bcl‐2 expression, and decreased the expression of pro‐apoptotic p53, Bax, and caspase‐3 in the colon. Germinated brown rice alone or combined with probiotics inhibited the formation of MDF in the middle colon, enhanced the colonic expression of p53 and Bax, and increased the ratio of Bax/Bcl‐2. Combined treatment of GBR and probiotics inhibited the formation of ACF‐producing sialomucin (SIM‐ACF) and recovered the activity of SOD in the colon. Combination of GBR and L. acidophilus further increased caspase‐3 expression and decreased Bcl‐2 expression. These findings suggest that GBR combined with L. acidophilus and/or B. animalis subsp. lactis may inhibit colorectal carcinogenesis by enhancing antioxidative capacity and inducing apoptosis. This synbiotics may be a potential functional food or chemopreventive agent for controlling colorectal cancer.
A Flexible, Self‐Floating Composite for Efficient Water Evaporation
Authors: Fang Zhenxing , Jiao Shihui , Wang Boran , Yin Wen , Pang Guangsheng 
Published: November 2018

AbstractA flexible, self‐floating W18O49/carbon foam composite is fabricated by calcining melamine foam with W18O49 as an adsorbate in N2 atmosphere. This self‐floating property is simply realized by a carbonization process other than the complicated surface modification process. The simple synthesis procedure helps to increase not only the solar absorption but also the retention of W18O49 in the porous net structure. This composite absorbs almost the whole solar spectrum and generates localized heat at the surface, which is beneficial for water evaporation. Its water evaporation rate is 6.6 times higher than that of pure water. It has a stable cyclic performance over ten cycles under the illumination of simulated sunlight (500 W Xe lamp). Its flexibility makes it easy to reuse and transfer, which is evaluated by the bending deformation test. The W18O49/carbon foam composite is a prospective material in solar energy conversion field, and the preparation procedure is feasible to scale‐up.
Microglial glutamate release evoked by α‐synuclein aggregates is prevented by dopamine
Authors: dos‐Santos‐Pereira Mauricio , Acuña Leonardo , Hamadat Sabah , Rocca Jeremy , González‐Lizárraga Florencia , Chehín Rosana , Sepulveda‐Diaz Julia , Del‐Bel Elaine , Raisman‐Vozari Rita , Michel Patrick P. 
Published: November 2018

AbstractWhen activated, microglial cells have the potential not only to secrete typical proinflammatory mediators but also to release the neurotransmitter glutamate in amounts that may promote excitotoxicity. Here, we wished to determine the potential of the Parkinson's disease (PD) protein α‐Synuclein (αS) to stimulate glutamate release using cultures of purified microglial cells. We established that glutamate release was robustly increased when microglial cultures were treated with fibrillary aggregates of αS but not with the native monomeric protein. Promotion of microglial glutamate release by αS aggregates (αSa) required concomitant engagement of TLR2 and P2X7 receptors. Downstream to cell surface receptors, the release process was mediated by activation of a signaling cascade sequentially involving phosphoinositide 3‐kinase (PI3K) and NADPH oxidase, a superoxide‐producing enzyme. Inhibition of the Xc‐ antiporter, a plasma membrane exchange system that imports extracellular l‐cystine and exports intracellular glutamate, prevented the release of glutamate induced by αSa, indicating that system Xc‐ was the final effector element in the release process downstream to NADPH oxidase activation. Of interest, the stimulation of glutamate release by αSa was abrogated by dopamine through an antioxidant effect requiring D1 dopamine receptor activation and PI3K inhibition. Altogether, present data suggest that the activation of microglial cells by αSa may possibly result in a toxic build‐up of extracellular glutamate contributing to excitotoxic stress in PD. The deficit in dopamine that characterizes this disorder may further aggravate this process in a vicious circle mechanism.
LAR and PTPσ receptors are negative regulators of oligodendrogenesis and oligodendrocyte integrity in spinal cord injury
Authors: Dyck Scott , Kataria Hardeep , Akbari‐Kelachayeh Khashayar , Silver Jerry , Karimi‐Abdolrezaee Soheila 
Published: November 2018

AbstractFollowing spinal cord injury (SCI), the population of mature oligodendrocytes undergoes substantial cell death; promoting their preservation and replacement is a viable strategy for preserving axonal integrity and white matter repair in the injured spinal cord. Dramatic upregulation of matrix chondroitin sulfate proteoglycans (CSPGs) is shown to pose an obstacle to endogenous repair processes, and targeting CSPGs improves functional recovery after SCI. However, the cellular and molecular mechanisms underlying the inhibitory effects of CSPGs remain largely undefined. Modulation of CSPGs specific signaling receptors, leukocyte common antigen‐related (LAR), and protein tyrosine phosphatase‐sigma (PTPσ) allows us to uncover the role and mechanisms of CSPGs in regulating oligodendrocytes in SCI. Here, utilizing specific functionally blocking peptides in a clinically relevant model of contusive/compressive SCI in the rat, we demonstrate that inhibition of PTPσ and LAR receptors promotes oligodendrogenesis by endogenous precursor cells, attenuates caspase 3‐mediated cell death in mature oligodendrocytes, and preserves myelin. In parallel in vitro systems, we have unraveled that CSPGs directly induce apoptosis in populations of neural precursor cells and oligodendrocyte progenitor cells and limit their ability for oligodendrocyte differentiation, maturation, and myelination. These negative effects of CSPGs are mediated through the activation of both LAR and PTPσ receptors and the downstream Rho/ROCK pathway. Thus, we have identified a novel inhibitory role for PTPσ and LAR in regulating oligodendrocyte differentiation and apoptosis in the injured adult spinal cord and a new feasible therapeutic strategy for optimizing endogenous cell replacement following SCI.
MicroRNA expression profiles discriminate childhood T‐ from B‐acute lymphoblastic leukemia
Authors: Almeida Renata Santos , Costa e Silva Matheus , Coutinho Luiz Lehmann , Garcia Gomes Renan , Pedrosa Francisco , Massaro Juliana Doblas , Donadi Eduardo Antônio , Lucena‐Silva Norma 
Published: November 2018

AbstractMicroRNAs (miRNAs) play a critical role on biological and cellular processes; the search for functional markers may be of importance for differential diagnosis, prognosis, and development of new therapeutic regimens. In this context, we evaluated the bone marrow miRNA profile of Brazilian children exhibiting T‐ or B‐cell acute lymphoblastic leukemia (T‐ALL or B‐ALL), using massive parallel sequencing, using the HiSeq 2500 platform (Illumina). The differential expression analysis was conducted considering a leave‐one‐out approach and FDR ≤ 0.05. Machine learning algorithms were applied to search for the disease subset biomarkers. Target prediction, functional enrichment, and classification of biological categories were also performed. Sixteen miRNAs were differentially expressed between T‐ and B‐ALL, of which 10 (miR‐708‐5p, miR‐497‐5p, miR‐151a‐5p, miR‐151b, miR‐371b‐5p, miR‐455‐5p, miR‐195‐5p, miR‐1266‐5p, miR‐574‐5p, and miR‐425‐5p) were downregulated and six (miR‐450b‐5p, miR‐450a‐5p, miR‐542‐5p, miR‐424‐5p, miR‐629‐5p, and miR‐29c‐5p) were upregulated in childhood T‐ALL. These miRNAs may be used for distinguishing childhood lymphoblastic leukemia subtypes, since it provided the clear separation of patients in these two distinct groups. Six relevant biological pathways were identified according to their role in leukemia, namely, viral carcinogenesis, cell cycle, and B‐cell receptor signaling pathways for induced miRNAs and TGF‐beta signaling, apoptosis, and NF‐kappa B signaling for the repressed miRNAs, of which several miRNA gene targets participate in cell differentiation and hematopoiesis processes. Machine learning analysis pointed out miR‐29c‐5p expression as the best discriminator between childhood T‐ and B‐ALL, which is involved in calcium signaling, critical for B‐cell lymphocyte fate. Further studies are needed to assure the role of the 16 miRNAs and miR‐29c‐5p on acute lymphoblastic leukemia subtypes and on disease prognosis.
Sensitivity of streamflow simulation in the Delaware River Basin to forecasted land‐cover change for 2030 and 2060
Authors: Williamson Tanja N. , Claggett Peter 
Published: November 2018

AbstractIn order to simulate the potential effect of forecasted land‐cover change on streamflow and water availability, there has to be confidence that the hydrologic model used is sensitive to small changes in land cover (<10%) and that this land‐cover change exceeds the inherent uncertainty in forecasted conditions. To investigate this, a 26‐year streamflow record was simulated for 33 basins (54–928 km2) in the Delaware River Basin using three dates of land cover: the 2011 National Land‐Cover Dataset (Homer, Fry, & Barnes, ), 2030 land‐cover conditions representing median values from 101 equally‐likely forecasts, and 2060 land‐cover conditions corresponding to the same iterations used to represent 2030. Streamflow was simulated using a process‐based hydrologic model that includes both pervious and impervious methods as parameterized by three land‐cover‐based hydrologic response units (HRUs)—forested, agricultural, and developed land. Small, but significant differences in streamflow magnitude, variability, and seasonality were seen among the three time periods—2011, 2030, and 2060. Temporal differences were discernible from the range of conditions simulated with 101 equally likely forecasts for 2030. Development was co‐located with the most frequent landscape components, as characterized by topographic wetness index, resulting in a change in hydrology for each HRU, highlighting that knowing the location of disturbance is key to understanding potential streamflow changes. These results show that streamflow simulation using regional calibration that incorporates land‐cover‐based HRUs can be sensitive to relatively small changes in land‐cover and that temporal trends resulting from land‐cover change can be isolated in order to evaluate other changes that might affect water resources.
Tidally‐averaged flows in the interior Sacramento–San Joaquin River Delta: Trends and change attribution
Authors: Hutton Paul H. , Chen Limin , Rath John S. , Roy Sujoy B. 
Published: November 2018

AbstractThe hydrology of the San Francisco Bay‐Delta estuary (the Delta) has been significantly modified over the past 150 years to serve a variety of human needs for water supply and food production, albeit with adverse ecological impacts. These adverse impacts, in concert with evolving societal values, have motivated change in the estuary's water management to promote ecosystem restoration goals while continuing to support human uses. Understanding historical flow patterns, as well as the environmental functions provided by these flow patterns, is critical to restoration planning. Building upon previous work on outflow trends from the Delta to San Francisco Bay, this paper evaluates historical trends in key interior Delta flows spanning nine decades (1922–2016) and presents an attribution of these trends to various anthropogenic drivers. We reconstructed historical time series records at four key locations in the interior of the Delta; these time series represent tidally‐averaged flows that are intensively managed and are of great importance to the beneficial uses of water in the region. We derived several scenario‐based flow time series at these same four locations to assist in attributing change to a variety of drivers, including reservoir and export pumping operations, in‐Delta barrier and gate operations, and upstream water diversions. Flow changes were measured relative to 1920‐level land use and water management conditions. We find the four interior Delta locations to have distinct seasonal flow trends and, in general, unique responses to various drivers of change. Our work highlights the complex nature of historical flow changes in a highly‐managed estuarine ecosystem, and the types of modifications that would be necessary to reverse these changes.
Effects of instream processes, discharge, and land cover on nitrogen export from southern Appalachian Mountain catchments
Authors: Webster Jackson R. , Stewart Rebecca M. , Knoepp Jennifer D. , Jackson C. Rhett 
Published: November 2018

AbstractCatchments with minimal disturbance usually have low dissolved inorganic nitrogen (DIN) export, but disturbances and anthropogenic inputs result in elevated DIN concentration and export and eutrophication of downstream ecosystems. We studied streams in the southern Appalachian Mountains, USA, an area dominated by hardwood deciduous forest but with areas of valley agriculture and increasing residential development. We collected weekly grab samples and storm samples from nine small catchments and three river sites. Most discharge occurred at baseflow, with baseflow indices ranging from 69% to 95%. We identified three seasonal patterns of baseflow DIN concentration. Streams in mostly forested catchments had low DIN with bimodal peaks, and summer peaks were greater than winter peaks. Streams with more agriculture and development also had bimodal peaks; however, winter peaks were the highest. In streams draining catchments with more residential development, DIN concentration had a single peak, greatest in winter and lowest in summer. Three methods for estimating DIN export produced consistent results. Annual DIN export ranged from less than 200 g ha−1 year−1 for the less disturbed catchments to over 2,000 g ha−1 year−1 in the catchments with the least forest area. Land cover was a strong predictor of DIN concentration but less significant for predicting DIN export. The two forested reference catchments appeared supply limited, the most residential catchment appeared transport limited, and export for the other catchments was significantly related to discharge. In all streams, baseflow DIN export exceeded stormflow export. Morphological and climatological variation among watersheds created complexities unexplainable by land cover. Nevertheless, regression models developed using land cover data from the small catchments reasonably predicted concentration and export for receiving rivers. Our results illustrate the complexity of mechanisms involved in DIN export in a region with a mosaic of climate, geology, topography, soils, vegetation, and past and present land use.
Do foreign portfolio capital flows affect domestic investment? Evidence from Brazil
Authors: Colombo Jefferson A. , Loncan Tiago R. , Caldeira João F. 
Published: November 2018

AbstractAlthough there are several direct and indirect theoretical channels through which foreign capital flows may affect domestic investment, empirical evidence remains inconclusive. In this paper, we employ a VARX framework to assess the impact of equity foreign portfolio investment (EFPI) on domestic investment growth, employing monthly series for the Brazilian economy. Our results suggest that EFPI played a nonnegligible role in explaining aggregate investment fluctuations, but only before the 2008 global financial crisis. After the crisis, a period marked first by a shift in economic policy in 2008–2009, with substantial increases in government intervention, followed by deterioration in the institutional outlook and political stability in 2014–2015, mostly against the backdrop of the Petrobras corruption scandal, unexpected shocks to EFPI no longer led any real effects on investment growth. Although, in general, our results vouch for beneficial effects of equity capital flows on investment, this virtuous relationship is likely disturbed by interventionist policies and political unrest.
Expectation hypothesis and term structure anomaly
Authors: Kuo I‐Doun , Chen Cathy Yi‐Hsuan , Huang Kai‐Min 
Published: November 2018

AbstractCampbell and Shiller (1991) find the presence of term structure anomaly, in which the slope of the term structure predicts inconsistently to the change in yield of longer term bonds over the life of shorter term bonds during 1952–1987. Focusing on the post Campbell and Shiller period, our findings suggest that the anomaly is not only attributed to term premia but also relates to expectation errors. We found that macroeconomic surprises and irrationality from investors' behaviour are important determinants of time‐varying expectation errors. These factors are capable of explaining the rejection of the expectation hypothesis and the U.S. term structure anomaly in long‐term securities.
Recombinant Human Bone Morphogenetic Protein 6 Delivered Within Autologous Blood Coagulum Restores Critical Size Segmental Defects of Ulna in Rabbits
Authors: Grgurevic Lovorka , Oppermann Hermann , Pecin Marko , Erjavec Igor , Capak Hrvoje , Pauk Martina , Karlovic Sven , Kufner Vera , Lipar Marija , Bubic Spoljar Jadranka , Bordukalo‐Niksic Tatjana , Maticic Drazen , Peric Mihaela , Windhager Reinhard , Sampath T Kuber , Vukicevic Slobodan 
Published: November 2018

ABSTRACTBMP2 and BMP7, which use bovine Achilles tendon–derived absorbable collagen sponge and bovine bone collagen as scaffold, respectively, have been approved as bone graft substitutes for orthopedic and dental indications. Here, we describe an osteoinductive autologous bone graft substitute (ABGS) that contains recombinant human BMP6 (rhBMP6) dispersed within autologous blood coagulum (ABC) scaffold. The ABGS is created as an injectable or implantable coagulum gel with rhBMP6 binding tightly to plasma proteins within fibrin meshwork, as examined by dot‐blot assays, and is released slowly as an intact protein over 6 to 8 days, as assessed by ELISA. The biological activity of ABGS was examined in vivo in rats (Rattus norvegicus) and rabbits (Oryctolagus cuniculus). In a rat subcutaneous implant assay, ABGS induced endochondral bone formation, as observed by histology and micro‐CT analyses. In the rabbit ulna segmental defect model, a reproducible and robust bone formation with complete bridging and restoration of the defect was observed, which is dose dependent, as determined by radiographs, micro‐CT, and histological analyses. In ABGS, ABC scaffold provides a permissive environment for bone induction and contributes to the use of lower doses of rhBMP6 compared with BMP7 in bovine bone collagen as scaffold. The newly formed bone undergoes remodeling and establishes cortices uniformly that is restricted to implant site by bridging with host bone. In summary, ABC carrier containing rhBMP6 may serve as an osteoinductive autologous bone graft substitute for several orthopedic applications that include delayed and nonunion fractures, anterior and posterior lumbar interbody fusion, trauma, and nonunions associated with neurofibromatosis type I. © 2018 American Society for Bone and Mineral Research.
Adding Lateral Spine Imaging for Vertebral Fractures to Densitometric Screening: Improving Ascertainment of Patients at High Risk of Incident Osteoporotic Fractures
Authors: Prince Richard L , Lewis Joshua R , Lim Wai H , Wong Germaine , Wilson Kevin E , Khoo Ben C , Zhu Kun , Kiel Douglas P , Schousboe John T 
Published: November 2018

ABSTRACT

The current diagnosis of osteoporosis is limited to a T-score ≤–2.5. However, asymptomatic vertebral fractures (VF) are known to predict a high risk of subsequent fractures and pharmaceutical intervention is known to reduce future fracture risk in these individuals. In a prospective, population-based cohort of ambulant older women, we sought to evaluate the role of VF detection by screening densitometric lateral spine imaging (LSI) for VF at time of bone density testing to the effect on the magnitude of fracture risk. A total of 1084 women (mean age 75 years ± SD 3 years) had baseline LSI that identified 100 (9%) women with VFs and 89 (8%) with femoral neck (FN) T-score osteoporosis ≤–2.5. Follow-up identified incident clinical spine fracture in 73 (7%), 305 (28%) with any fracture-related hospitalization, and 121 (11%) with a hip fracture–related hospitalization. Compared with those without baseline VF, in those with baseline VF, relative risk (RR) for incident clinical spine, hip, and any fracture were 3.46 (95% confidence interval [CI] 2.14–5.60, p &lt; 0.001); 1.72 (95% CI 1.09–2.71, p = 0.02), and 1.4 (95% CI 1.07–1.84, p = 0.02), respectively. In 675 (62%) of women with femoral neck osteopenia (T-score &lt;–1 to &gt;–2.5), 61 (9%) also had a VF. Compared with those without baseline VF, RR for any incident fragility fractures and fractures at spine and hip in those with baseline VF were 1.6 (95% CI 1.2–2.1, p &lt; 0.01), 3.9 (95% CI 2.2–6.9, p &lt; 0.01), and 1.6 (95% CI 0.9–2.8, p = 0.10), respectively. On basis of the prognosis, older women with LSI VF with osteopenia should be diagnosed with osteoporosis and should be considered for pharmaceutical intervention. © 2018 American Society for Bone and Mineral Research.