bluuebunny/crossref_metadata_2025_split huggingface dataset:
La paradoja de Costa Rica (1984-2018): Éxito exportador y heterogeneidad estructural
Authors: Govaere Vicarioli Velia 
Published: July 2019

Este texto aborda la fisura entre el exitoso desarrollo exportador costarricense y las discordancias productivas, laborales, sociales, educativas y territoriales que destacan la heterogeneidad del modelo nacional de desarrollo. Desde 1984 tuvo lugar un cambio de paradigmas en las políticaspúblicas de la CEPAL de la época, que daban un papel predominante al proteccionismo de la producción doméstica y a la intervención del Estado en la economía. El cambio de modelo giró hacia la inserción en el comercio internacional, pero los resultados de ese cambio han sido contradictorios. Un notable éxito exportador está contrapuesto a debilidades del parque empresarial endógeno debaja modernidad y competitividad, flaquezas educativas, creciente desigualdad de ingresos y brechas territoriales. Este artículo plantea que las asimetrías nacionales son productode un cambio inconcluso de paradigma, que sobredimensionó la internacionalización y descuidó desfases internos derivados o acentuados por ella. Se aboga por políticas públicas más holísticas que hagan más completo el modelo.
Markers of Collagen Formation and Degradation Reflect Renal Function and Predict Adverse Outcomes in Patients With Type 1 Diabetes
Authors: Pilemann-Lyberg Sascha , Rasmussen Daniel Guldager Kring , Hansen Tine Willum , Tofte Nete , Winther Signe Abitz , Holm Nielsen Signe , Theilade Simone , Karsdal Morten Asser , Genovese Federica , Rossing Peter 
Published: July 2019

OBJECTIVE
Patients with type 1 diabetes (T1D) have a higher risk of developing chronic kidney disease, cardiovascular events (CVEs), and mortality than the general population. We hypothesized that two previously published biomarkers, namely PRO-C6, a biomarker of collagen type VI formation, and C3M, a biomarker of collagen type III degradation, may be associated with impaired renal function and have prognostic value for adverse renal, CVE, and mortality in patients with T1D.

RESEARCH DESIGN AND METHODS
PRO-C6 and C3M in serum (sPRO-C6, sC3M) and urine (uPRO-C6, uC3M) were measured by ELISA in 663 patients with T1D ranging from normoalbuminuric to macroalbuminuric. Association of the biomarkers with mortality, CVEs, heart failure, decline in estimated glomerular filtration rate (eGFR) ≥30%, and end-stage renal disease (ESRD) were tested in Cox proportional hazards models after log2 transformation and adjusted for relevant clinical characteristics. Hazard ratios (HRs) were reported per doubling of biomarker levels.

RESULTS
High levels of sPRO-C6 were independently associated with a higher risk of all-cause mortality (HR 2.26 [95% CI 1.31–3.87], P &lt; 0.0031). There was an association with higher risk of CVEs (n = 94) and heart failure (n = 28) but not after adjustment (P ≥ 0.58). In relation to renal outcomes, adjusted sPRO-C6 was associated with a higher risk of eGFR decline ≥30% in T1D, with eGFR &gt;45 and &gt;30 mL/min/1.73 m2, and with a higher risk of ESRD (all P ≤ 0.03). Higher uPRO-C6 was associated with a lower risk of decline in eGFR.

CONCLUSIONS
In patients with T1D, higher sPRO-C6 was an independent predictor of both decline in eGFR and development of ESRD and of all-cause mortality. Higher uPRO-C6 was also associated with a lower risk of decline in eGFR.
Functional activity of p-glycoprotein in blood-brain barrier during experimental par-kinson's syndrome
Authors: Chernykh Ivan V. , Shchulkin Aleksey V. , Mylnikov Pavel Yu. , Gatsanoga Maria V. , Gradinar Maria M. , Yesenina Anna S. , Yakusheva Elena N. 
Published: July 2019

Background. P-glycoprotein (Pgp, ABCB1-protein) is a membrane transporter with broad substrate specificity that is localized in hepatocytes, enterocytes, epithelial renal tubules, and also in tissue barriers, including blood-brain barrier (BBB). Increased Pgp activity in BBB is one of the reasons for the pharmacoresistance of a number of CNS diseases.
Aim. Analysis of Pgp functional activity in BBB during experimental Parkinson's syndrome.
Materials and Methods. The work was performed on 90 Wistar rats, divided into 3 series (n=30 in each). The 1 series (control) was subcutaneously injected sunflower oil once a day for 7 days, and Pgp activity in BBB was assessed on the 8th day. The 2 and 3 series (pathology control) - were administered rotenone at a dose of 2.5 mg/kg once a day for 7 and 28 days respectively to simulate parkin-sonism. At the end of the experiment Pgp activity was estimated. To confirm Parkinson's syndrome, in addition to the clinical picture, level of dopamine in midbrain and striatum was determined using enzyme-linked immunosorbent assay. Pgp functional activity in BBB was assessed by the degree of penetration of its marker substrate fexofenadine into the brain after its intravenous administration at a dose of 10 mg/kg. The content of fexofenadine in the blood plasma and in brain tissue was estimated by the area under pharmacokinetic curve of the substance (in the blood or brain tissues) - AUC0-t(plasma) or AUC0-t(brain) respectively. To assess the BBB permeability the ratio AUC0-t(brain) / AUC0-t(plasma) was calculated.
Results. Rotenone administration led to the development of parkinsonism typical picture: muscle stiffness, hypokinesia, gait instability. There was a decrease in dopamine level in the striatum after 7 days by 69.6% (p=0.095), after 28 days - by 93.9% (p=0.008), in midbrain - by 72.7% (p=0.095) and 68.7% (p=0.032) respectively. Fexofenadine AUC0-t(plasma) and AUC0-t(brain) after its intravenous administration to control rats were 266.2 (246.4; 285.6) μg/ml*min and 5.9 (5.8;6.6) µg/g*min respectively, AUC0-t(brain) /AUC0-t(plasma) - 0.020 (0.019; 0.022). When rotenone was for 7 days administered - fexofenadine AUC0-t(brain) increased 2.02 times (p=0.0163), AUC0-t(brain) / AUC0-t(plasma) - 2.4 times (p=0.0283). 28 days administration of rotenone led to augmentation of AUC0-t(brain) of fexofenadine by 1.75 times (p=0.0283), AUC0-t(brain) / AUC0-t(plasma) - by 2.27 times (p=0.0163).
Conclusions. The development of Parkinson’s syndrome, caused by the administration of rotenone, inhibits Pgp functional activity in BBB, which is confirmed by the accumulation in the brain marker substrate of the transporter - fexofenadine.
Condition of microcirculatory and hemostasis systems in rats after moderate hypothermia
Authors: Lycheva Natalia A. , Shakhmatov Igor I. , Sedov Anton V. , Makushkina Daria A. , Vdovin Vyacheslav M. 
Published: July 2019

Hypothermia produces a generalized impact on an organism, with involvement of all organs and systems into the response. It was shown that hypothermia promotes multi-organ dysfunction syndrome, which makes it important to study the influence of hypothermia on condition of hemostasis and microcirculatory systems.
Aim. To study the condition of the hemostasis system and the microcirculatory bed in different periods of moderate hypothermia in rats.
Materials and Methods. The current study was performed on 50 male Wistar rats. Condition of microcirculatory blood stream in all animals was assessed with laser Doppler flowmetry. Condition of hemostasis system was studied according to routine protocols and an integrated method of examination – thromboelastography. Statistical analysis was performed using Statistica 6.0 software package (StatSoft, USA) with calculation of Mann-Whitney nonparametric test.
Results. Analysis of the experimental data showed that moderate hypothermia produced a pronounced modulating influence on the microcirculatory system. Vasodilatation occurred immediately after reaching the stage of hypothermia, suggesting the beginning of decompensation in the experimental animals. The highest risk for hemodynamic pathologies was observed 5 days after cessation of cooling and was characterized by a massive reduction in the vascular tone, intensification of hemodynamics against the background appearance of thrombinemia markers in the blood stream and pronounced inhibition of fibrinolysis. Enhanced hemodynamics of the nutritional vascular bed with the underlying progressive prothrombotic condition is a potent risk factor for thrombosis and multiple organ dysfunction syndrome. Vasospasm that developed 2 weeks after recovery of the body temperature, indicated a profound modulation of vasculature and preservation of high-level sympathetic input, as well as increasing rigidity of blood vessel walls. Rising fibrinogen concentrations confirm a progressive inflammatory reaction.
Conclusion. A moderate degree of hypothermia produces a pronounced modulating effect on the microcirculation. The established regularities make it possible to form a clear understanding of the course and development of the pathological reaction in the body of victims and to give recommendations on the use of pharmacological medicine for preventive therapy. Thus, a period has been established when thrombotic readiness is maximal, and use of anticoagulant and antiplatelet drugs is required, together with drugs that improve rheological properties of blood.
Funções de duas variáveis, representação gráfica e integração
Authors: Fortes Cruz João Manuel 
Published: July 2019

O trabalho expõe a introdução do software GeoGebra como revezamento no ensino da Representação Gráfica, Imagens de Domínios e Integração de Funções de Duas Variáveis. A experiência propõe o reconhecimento das potencialidades deste software na resolução de questões matemáticas que integrem representação gráfica em funções de duas variáveis, bem como a do domínio das mesmas e sua integração. A função de duas variáveis é conteúdo da grelha curricular do Plano de Estudos do Ensino Superior em algumas Universidades do País e o software GeoGebra oferece recursos didáticos que facilitam o seu ensino. Concretizou-se em um briefing de três reuniões, com a participação de cinco professores. A metodologia utilizada para alcançar os objetivos baseia-se no estudo de caso do tipo descritivo com análise essencialmente qualitativa.
Endoscopic Foraminotomy in Spinal Epidural Lipomatosis, Case Report
Authors: Quillo-Olvera Diego , Kim Jin Sung , Quillo-Olvera Javier , Quillo-Resendiz Javier 
Published: July 2019

A 69-year-old woman with a history of hypertension and Cushing's syndrome, Her symptoms onset a year ago with pain in both legs treated with analgesics, but continued with right L4-L5 radiculopathy, she underwent treatment with endoscopy lumbar transforaminal, relieving his discomfort in the right leg, indicating on the visual analog scale (VAS) a score of 2/10. Four months later she started with pain in the left leg pointing to VAS of 7/10 in the disposition of the roots of L4-L5. Magnetic resonance imaging (MRI) of lumbar spine in sagittal and axial sequence weighted in T1 and T2 showed an excess of epidural fat and compression of the dural sac from L1 to S1. After the clinical-radiological assessment, the patient was treated with a left L4-L5 endoscopic foraminotomy in which adipose tissue was obtained and a decompression of the neural structures was achieved, the pain and weakness of the leg improved, indicated a VAS of 2/10 and the MacNab criteria scale for clinical graduation reported as good.
We present a case of spinal epidural lipomatosis caused by Cushing's syndrome in a patient who underwent a lumbar endoscopic foraminotomy for radicular pain in a hospital in Korea.
Spinopelvic Parameters in Anterior Lumbar Interbody Fusion, the First Follow-Up Study of Three Years in Mexican Population
Authors: Quillo-Olvera Diego , Quillo-Olvera Javier , Quillo-Resendiz Javier , Vega-Sosa Alfonso 
Published: July 2019

Objective: The objective of this work is to identify the modifications of the spinopelvic balance posterior to the ALIF and therefore its clinical repercussion.
Methods: A retrospective study of 20 patients were included, patients treated with ALIF was performed by 2 neurosurgeons and 1 vascular surgeon in 1 medical center in 2015, clinical data and radiographic measurements pre and postoperative at 3 years follow-up were studied.
Results: The number of patients was 20;16 females (80%) and 4 males (20%), with a follow-up 36 months, the mean age of the studied group was 50.1 ± 8.5years (range 35-67 years), body mass index (BMI) was 29± 3.5, two of the 20 patients (10%) had undergone prior spine surgery, a total of 26 ALIF levels were treated in 20 patients, fourteen patients (70%) underwent 1 level L5-S1 and six patients (6%) underwent 2 level L4-L5,L5-S1. All ALIF cages were supplemented with anterior integrated fixation, Eigth(40%) of 20 patients were treated with posterior spinal fixation in addition to their ALIF procedure, Twelve (60%) of 20 patients were standalone ALIF. The mean hospital stay after ALIF procedure were 4.05± 1.87 days (range 2-9 days).
PI,SS,PT and LL were measures pre and the postoperative was the last reported during the 3 years follow up, PI and SS has statistically significant (p= 0.008 and 0.012)correspondingly. visual analog scale (VAS) was the measure preoperative and the postoperative was the last reported getting statistically significant (p= 0.001) and the complications obtained in 4 cases were persistent pain, bleeding, intestinal pseudoclusion and retrograde ejaculation.
Conclusions: The interaction between the anatomy of the pelvis and the paravertebral muscles have a direct influence on the stress of the intervertebral discs, improving the posture of the spine and minimizing energy expenditure.
In this work performed the changes in the espinopelvic parameters that are described in the literature were obtained; we know that the ALIF improves the pelvic incidence and therefore the lumbar lordosis postoperative. Here we could verify that the modification of spinopelvic balances is related to the clinical improvement of the patient in the follow-up after his surgery, however is necessary to demonstrate quantitatively the modification of these parameters in our population to justify that the surgery is a satisfactory result for the patient.
Voter Education for First Time Voters through Rumah Pintar Pemilu
Authors: Rafni Al , Suryanef Suryanef 
Published: July 2019

Voter education for first time voters is important given the group’s potential in contributing to 30% of overall voters. Unfortunately, the potential is not well managed through systematical and comrprehensive voter education. Rumah Pintar Pemilu (Election Smart House/RPP) is one of the priorities of the Election Commission (KPU) that functions as a voter education service center. It has become a facility for first time voters to understand about the election and democracy in general. This research used research and development (R&D) method. Data was collected through deep interview, focus group discussion (FGD), and documentation study. The result shows the RPP’s potential in serving voter education for first time voters and how RPP is developed as a political education facility in cities/regencies.
Keywords: voter education, first time voters, learning resources
ABSTRAK
Pendidikan pemilih bagi pemilih pemula menjadi penting mengingat potensi suara yang ada pada kelompok ini memiliki kontribusi lebih kurang 30% dari jumlah pemilih. Sayangnya potensi sebesar itu seringkali tidak dikelola dengan baik melalui pendidikan pemilih yang sistematis dan komprehensif. Kehadiran Rumah Pintar Pemilu (RPP) sebagai salah satu program prioritas Komisi Pemilihan Umum (KPU) yang berfungsi sebagai pusat layanan pendidikan pemilih menjadi wahana tersendiri bagi pemilih pemula untuk mengerti tentang pemilu dan kehidupan demokrasi pada umumnya. Penelitian ini menggunakan metode pengembangan atau Research and Development (R&D). Data penelitian dikumpulkan melalui teknik wawancara mendalam, focus group discussion (FGD), dan studi dokumentasi. Hasil penelitian menggambarkan potensi RPP dalam memberikan layanan pendidikan pemilih bagi pemilih pemula dan bagaimana RPP dikembangkan sebagai sarana pendidikan politik di kabupaten/kota.
Kata Kunci: pendidikan pemilih, pemilih pemula, sumber belajar
ANALISIS KARYA LUKIS PADA BOTOL KACA BEKAS DENGAN MENERAPKAN ORNAMEN SUMATERA UTARA OLEH SISWA KELAS XI SMAS AL-WASHLIYAH PASAR SENEN MEDAN T.A 2018/2019 DITINJAU DARI PRINSIP-PRINSIP DESAIN
Authors: Siregar Purnama Sari , Sihite Onggal , Erdansyah Fuad 
Published: July 2019

AbstrakPenelitian ini bertujuan untuk memperkenalkan ornamen Sumatera Utara kepada siswa serta melatih kemampuan siswa dalam melukis ornamen dengan menerapkan prinsip-prinsip desain. Melukis ornamen adalah salah satu cara mengenal dan memelihara ornamen. Tahapan penelitian ini diawali dengan pembelajaran tentang ornamen Sumatera Utara dan prinsip-prinsip desain. Selanjutnya siswa diberi tugas untuk melukis ornamen Sumatera Utara. Artinya, siswa bebas mengekspresikan konsepnya lewat bentuk-bentuk ornamen tersebut. Metode penelitian yang dilakukan adalah deskriptif kualitatif yang menganalisis pengetahuan ornamen dan karya lukis ornamen siswa berdasarkan prinsip desain. Hasil penelitian menunjukkan adanya peningkatan pengetahuan tentang ornamen Sumatera Utara dan cukup baik dalam penerapan prinsip desain pada praktik melukis ornamen.Kata Kunci: ornamen, lukis, prinsip, desain.AbstractThis research purpose to introduce the North Sumatera ornaments to students and practice their skill in painting of ornaments with using the principles of design. Painting the ornaments is one way to recognize and maintain ornaments. The Step of research is begin with learning about North Sumatera ornaments and the principles of design. Then, students are given the task to paint the North Sumatera ornaments. That mean, students are free to express their concept with the shapes of that ornaments. The method of research conducted is qualitative descriptive which analyzing the ornaments knowledge and ornaments painting of students based on the principles of design. The result of this research show that there is creasing of the knowledge about North Sumatera Ornaments, and good enough in practice of painting ornament.Keywords: ornament, painting, principle, design.
KESESUAIAN POLA KEMEJA PRIA SISTEM ALDRICH TERHADAP PRIA BERTUBUH IDEAL INDONESIA
Authors: Fadillah Rosi Rizki , Adriani Adriani 
Published: July 2019

AbstrakTujuan penelitian untuk mendeskripsikan kelemahan, cara memperbaiki, serta kesesuaian pola kemeja pria sistem Aldrich terhadap pria bertubuh ideal Indonesia. Metode penelitian menggunakan penelitian terapan. Teknik analisa data menggunakan statistik deskriptif berupa perhitungan rumus persentase menggunakan microsoft excel. Objek penelitian yaitu pola kemeja pria sistem Aldrich yang diuji cobakan pada pria bertubuh ideal Indonesia, dengan tinggi 170 cm, berat 63 kg. Dinilai oleh 5 orang panelis yang ahli dibidang pola busana pria. Instrumen penelitian yang digunakan adalah kuesioner/angket memakai skala likerts. Hasil penelitian menunjukkan bahwa pola kemeja pria sistem Aldrich terhadap pria bertubuh ideal Indonesia, mempunyai 5 kelemahan berdasarkan penilaian dari 5 orang panelis diantaranya yaitu: 1) lingkar dada berlebih 3 cm, 2) lebar punggung berlebih 2,5 cm, 3) panjang kemeja kurang 5 cm, 4) lingkar kerung lengan berlebih 2,5 cm, 5) lingkar ujung lengan berlebih 2,5 cm. Cara memperbaikinya yaitu: 1) lingkar dada dikurangi 3 cm pada sisi kiri dan kanan, 2) lebar punggung dikurangi 2,5 cm pada sisi kiri dan kanan, 3) panjang kemeja ditambah 5 cm, 4) lingkar kerung lengan dikurangi 2,5 cm, 5) lingkar ujung lengan dikurangi 2,5 cm. Kesesuaian didapat dengan mencocokkan hasil dari kelemahan dan cara perbaikan pola kemeja pria sistem Aldrich terhadap pria bertubuh ideal Indonesia.Kata Kunci: kesesuaian, kemeja, aldrich, pria ideal.AbstractThe purpose of this study is to describe the weaknesses, how to improve, and the suitability of Aldrich's men's shirt pattern towards ideal Indonesian male posture. The method uses applied study. The data analysis was performed using descriptive statistics in the form of calculating formula percentages using Microsoft Excel. The object of this study was the Aldrich’s men shirt pattern which were tested on an ideal Indonesian male posture, with a height of 170 cm, weight of 63 kg. Judged by 5 panelists who are experts in men's clothing. The study instrument was a questionnaire / questionnaire using the Likerts scale. The results showed that the Aldrich’s men shirt pattern towards an ideal Indonesian male posture had 5 weaknesses based on the assessment from 5 panelists which were : 1) chest circumference over 3 cm, 2) back width over 2.5 cm, 3) shirt length less 5 cm, 4) sleeve circumference over 2.5 cm, 5) arm tip circumference over 2.5 cm. How to improve it are: 1) chest circumference shortened by 3 cm on the left and right side, 2) Back width shortened by 2.5 cm on the left and right side, 3) Shirt length extended by 5 cm, 4) Sleeve circumference shortened by 2.5 cm , 5) arm tip circumference shortened by 2.5 cm. The suitability is obtained by matching the results of the weaknesses and how to improve Aldrich's men shirt pattern towards ideal Indonesian male posture..Keywords: suitability, shirt, aldrich, ideal man.
PENGEMBANGAN CD INTERAKTIF BERBASIS TUTORIAL MATA KULIAH GAMBAR ANATOMI MAHASISWA TATA BUSANA JURUSAN IKK FPP UNP
Authors: Ys Afnur Saputri. , Nelmira Weni 
Published: July 2019

AbstrakMata kuliah gambar anatomi mempelajari pengetahuan dan keterampilan menggambar anatomi untuk desain busana. Dalam penyajian materi tersebut diperlukan media yang lebih inovatif dan interaktif sehingga dapat memotivasi mahasiswa dan dijadikan media pembelajaran secara mandiri. Penelitian ini bertujuan untuk menghasilkan media CD interaktif berbasis tutorial dalam pembelajaran gambar anatomi yang valid dan mengetahui respon mahasiswa yang menggunakannya. Penelitian ini merupakan Penelitian dan Pengembangan (R&D) dengan menggunakan model 4D dan penelitian ini hanya dilakukan sampai tahap develop saja. Media CD interaktif ini divalidasi oleh 4 orang validator dan uji coba dilakukan pada mahasiswa S1 Tata Busana tahun pelajaran 2016. Data yang dikumpulkan dari penelitian ini adalah data hasil validasi media CD interaktif berbasis tutorial, dan data respon mahasiswa terhadap media CD interaktif berbasis tutorial yang dihasilkan. Hasil validasi dianalisis secara deskriptif dan diperoleh skor 83 % dengan kategori sangat valid. Sedangkan respon mahasiswa setelah kegiatan uji coba secara umum positif.Kata Kunci: CD interaktif, gambar anatomi.AbstractThe subject of anatomy drawing studies insights and anatomy drawing skills for fashion design. In this presentation material, a more innovative and interactive media is needed so that it can motivate students and create learning media independently. This study aims to produce interactive CD media based on tutorials in learning valid anatomical images and learning responses used by students. This research is Research and Development (R & D) using the 4D model and this research can only be done until development. The interactive CD media was validated by 4 validators and the trial was conducted involving the 2016 Bachelor of Fashion Design students. The data collected from this study were the results of the tutorial interactive CD media validation, and the response of student data to the interactive CD media tutorial produced. The validation results were completed descriptively and obtained a score of 83% with a very valid category. While students' responses after the trial try were generally positive. Keywords: interactive CD, anatomical image.