bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prolonged venous transit is associated with lower odds of excellent recovery after reperfusion in anterior large‐vessel occlusion stroke
Authors: Salim Hamza Adel , Lakhani Dhairya A. , Mei Janet , Luna Licia , Shahriari Mona , Hyson Nathan Z. , Deng Francis , Dmytriw Adam A. , Guenego Adrien , Urrutia Victor C. , Marsh Elisabeth B. , Lu Hanzhang , Xu Risheng , Leigh Rich , Wolman Dylan , Shah Gaurang , Pulli Benjamin , Albers Gregory W. , Hillis Argye E. , Llinas Rafael , Nael Kambiz , Wintermark Max , Heit Jeremy J. , Faizy Tobias D. , Yedavalli Vivek 
Published: December 2024

AbstractBackground and purposeAcute ischemic stroke due to anterior circulation large‐vessel occlusion (AIS‐LVO) remains a leading cause of disability despite successful reperfusion therapies. Prolonged venous transit (PVT) has emerged as a potential prognostic imaging biomarker in AIS‐LVO. We aimed to investigate whether PVT is associated with a decreased likelihood of excellent functional outcome (modified Rankin Scale [mRS] score of 0–1 at 90 days) after successful reperfusion.MethodsIn our prospectively collected, retrospectively reviewed database, we analyzed data from 104 patients with AIS‐LVO who achieved successful reperfusion (modified Thrombolysis in Cerebral Infarction score of 2b/2c/3) between September 2017 and September 2022. PVT was defined as a time to maximum (Tmax) of ≥10 s in the superior sagittal sinus and/or torcula on computed tomography perfusion (CTP) imaging. Patients were categorized into PVT‐positive (PVT+) and PVT‐negative (PVT–) groups. The primary outcome was excellent functional recovery at 90 days.ResultsOf the 104 patients, 30 (29%) were PVT+. Excellent functional outcome was achieved in 38 patients (37%). PVT+ patients had a significantly lower rate of excellent recovery compared to PVT– patients (11% vs. 39%; p < 0.001). After adjusting for possible confounders, PVT positivity was independently associated with lower odds of excellent recovery (adjusted odds ratio 0.11, 95% confidence interval 0.02 to 0.48; p = 0.006).ConclusionsAmong patients with AIS‐LVO who achieved successful reperfusion, PVT positivity was independently associated with a decreased likelihood of excellent functional outcome at 90 days. Assessment of PVT on CTP may provide valuable prognostic information and aid in clinical decision making for patients with AIS‐LVO.
Genome‐Wide Diversity in Lowland and Highland Maize Landraces From Southern South America: Population Genetics Insights to Assist Conservation
Authors: Dominguez Pia Guadalupe , Gutierrez Angela Veronica , Fass Monica Irina , Filippi Carla Valeria , Vera Pablo , Puebla Andrea , Defacio Raquel Alicia , Paniego Norma Beatriz , Lia Veronica Viviana 
Published: December 2024

ABSTRACTMaize (Zea mays ssp. mays L.) landraces are traditional American crops with high genetic variability that conform a source of original alleles for conventional maize breeding. Northern Argentina, one the southernmost regions of traditional maize cultivation in the Americas, harbours around 57 races traditionally grown in two regions with contrasting environmental conditions, namely, the Andean mountains in the Northwest and the tropical grasslands and Atlantic Forest in the Northeast. These races encounter diverse threats to their genetic diversity and persistence in their regions of origin, with climate change standing out as one of the major challenges. In this work, we use genome‐wide SNPs derived from ddRADseq to study the genetic diversity of individuals representing the five groups previously described for this area. This allowed us to distinguish two clearly differentiated gene pools, the highland northwestern maize (HNWA) and the floury northeastern maize (FNEA). Subsequently, we employed essential biodiversity variables at the genetic level, as proposed by the Group on Earth Observations Biodiversity Observation Network (GEO BON), to evaluate the conservation status of these two groups. This assessment encompassed genetic diversity (Pi), inbreeding coefficient (F) and effective population size (Ne). FNEA showed low Ne values and high F values, while HNWA showed low Ne values and low Pi values, indicating that further genetic erosion is imminent for these landraces. Outlier detection methods allowed identification of putative adaptive genomic regions, consistent with previously reported flowering‐time loci and chromosomal regions displaying introgression from the teosinte Zea mays ssp. mexicana. Finally, species distribution models were obtained for two future climate scenarios, showing a notable reduction in the potential planting area of HNWA and a shift in the cultivation areas of FNEA. These results suggest that maize landraces from Northern Argentina may be unable to cope with climate change. Therefore, active conservation policies are advisable.
Exploring the Mediating Role of EFL Teachers’ Emotion Regulation in the Relationship Between Emotional Intelligence and Resilience
Authors: Liu Honggang , Liu Baochen , Zhou Xueheng 
Published: December 2024

ABSTRACTResearch on English as a foreign language (EFL) teachers’ psychology has been increasingly focusing on emotional intelligence (EI), emotion regulation (ER) and resilience due to the significant challenges these teachers face. However, the complex relationships among these three variables in the EFL teaching field have received scant attention. To address this gap, this study was conducted to test hypotheses regarding the relationships between EI, ER and resilience and the mediating role of ER. A survey was administered to 1017 junior high school EFL teachers from mainland China using three distinct scales to assess their levels of EI, ER and resilience. The data were analysed using SPSS 26.0 and Amos 24.0. The findings revealed that the EFL teachers demonstrated high levels of EI, ER and resilience. Furthermore, structural equation modelling showed that EI significantly predicted resilience, and cognitive reappraisal in ER significantly mediated this relationship. These results emphasize the importance of cultivating EI in enhancing EFL teachers’ psychological well‐being. Evidently, EI is a key factor in improving teacher resilience, and ER plays a crucial mediating role in this process, thereby enabling them to address professional challenges.
Established and Emerging Roles of DEAD/H‐Box Helicases in Regulating Infection and Immunity
Authors: Parthun Michael , Long Matthew E. , Hemann Emily A. 
Published: December 2024

ABSTRACTThe sensing of nucleic acids by DEAD/H‐box helicases, specifically retinoic acid‐inducible gene I (RIG‐I) and melanoma differentiation‐associated protein 5 (MDA5), plays a critical role in inducing antiviral immunity following infection. However, this DEAD/H‐box helicase family includes many additional proteins whose immune functions have not been investigated. While numerous DEAD/H‐box helicases contribute to antiviral immunity, they employ diverse mechanisms beyond the direct sensing of nucleic acids. Some members have also been identified to play proviral (promoting virus replication/propagation) roles during infections, regulate other non‐viral infections, and contribute to the regulation of autoimmunity and cancer. This review synthesizes the known and emerging functions of the broader DEAD/H‐box helicase family in immune regulation and highlights ongoing efforts to target these proteins therapeutically.
Erasing History as a Form of Defensive Forgetting
Authors: Berninger Anja 
Published: December 2024

ABSTRACTIt has sometimes been suggested that removing statues of problematic historical figures such as Cecil Rhodes from the public realm amounts to ‘erasing history’ and should therefore be avoided. In philosophy, this approach has generally been rejected. In this article, I try to develop a more plausible version of the erasing history argument. I suggest that sometimes societies aim to forget for defensive reasons (i.e. to cover up past wrongdoing). I also suggest that such past wrongdoing can also consist in the widespread acceptance of a problematic monument (and therewith complicity in the insult it represents). I conclude that in such cases, to avoid defensive forgetting, we should aim to recontextualize rather than remove the monument. I also discuss which forms such recontextualization may take.
No associations between neuroborreliosis in children and psychiatric neurodevelopmental disorders: a nationwide, population‐based, matched cohort study
Authors: Tetens Malte M. , Graham Emma E. , Andersen Nanna S. , Bangsborg Jette , Bodilsen Jacob , Dessau Ram B. , Ellermann‐Eriksen Svend , Jørgensen Charlotte Sværke , Møller Jens Kjølseth , Nielsen Alex Christian Yde , Pedersen Michael , Søgaard Kirstine K. , Obel Dorrit , Nygaard Ulrikka , Obel Niels , Lebech Anne‐Mette , Omland Lars Haukali 
Published: December 2024

BackgroundIt has been suggested that neuroborreliosis in children can manifest as psychiatric neurodevelopmental disorders or cause long‐term neurodevelopmental sequelae. However, previous studies were limited by size and design.MethodsWe performed a nationwide, population‐based, matched cohort study in Denmark between 1995 and 2021. We included all Danish residents <16 years old with a positive Borrelia burgdorferi sensu lato intrathecal antibody index test (children with neuroborreliosis). To form a comparison cohort, we randomly extracted individuals from the general population matched on date of birth and sex 10:1 to children with neuroborreliosis. We calculated hazard ratios (HRs) with 95% CIs of contact to departments of psychiatry, diagnosis of attention deficit disorder, diagnosis of learning or intellectual developmental disorders, or receipt of psychostimulants for attention deficit disorder among children with neuroborreliosis compared with comparison cohort members. We did a sensitivity analysis in the form of a case‐control study, where we examined whether these outcomes were more frequent among children with neuroborreliosis than in the comparison cohort before study inclusion to account for differential delay in diagnosis.ResultsWe included 1,132 children with neuroborreliosis and 11,320 comparison cohort members with an observation time of 168,858 person‐years. We found no associations between neuroborreliosis and contact with departments of psychiatry (HR: 1.0, 95% CI 0.9–1.2), diagnosis of attention deficit disorder (HR: 0.9, 95% CI 0.6–1.3), diagnosis of learning or intellectual developmental disorders (HR 0.8, 95% CI 0.5–1.4), or receipt of psychostimulants for attention deficit disorder (HR: 0.8, 95% CI 0.6–1.1). Also, in the sensitivity analyses, these outcomes were not more present among children with neuroborreliosis than in the comparison cohort before study inclusion.ConclusionsOur results do not support that neuroborreliosis in children manifests as psychiatric neurodevelopmental disorders or causes long‐term neurodevelopmental sequelae.
2024 European guidelines for the management of genital herpes
Authors: Patel Rajul , Moran Benjamin , Clarke Emily , Geretti Anna Maria , Lautenschlager Stephan , Green John , Donders Gilbert , Gomberg Mikhail , Samraj Shyam , Tiplica George Sorin , Foley Elizabeth 
Published: December 2024

AbstractGenital herpes is one of the most common sexually transmitted infections worldwide. Using the best available evidence, this guideline recommends strategies for diagnosis, management and follow‐up of the condition as well as for minimizing transmission. Early recognition and initiation of therapy is key and may reduce the duration of illness or avoid hospitalization with complications, including urinary retention, meningism or severe systemic illness. The guideline covers a range of common clinical scenarios, such as recurrent genital herpes, infection during pregnancy and coinfection with human immunodeficiency virus.
“Çété méné endan Lalwizyann”: The role of Haiti in representations of Louisiana Creole language and identity
Authors: Wendte Nathan A. 
Published: December 2024

AbstractMisconceptions about the ethnolinguistic relationship between Haiti and Louisiana persist to the present. Central to this debate is whether Louisiana Creole (LC) is a variety of French, an independent language, or a variant of the better‐known and more widely spoken Haitian Creole (HC). In this paper, I present data from residents of Louisiana and the greater Gulf South who invoke Haiti in reference to who and what are Creoles. Haiti surfaces in two primary ways: as a site of origin and authentication or as a site of difference and denaturalization. Haiti's indexical value and authenticating potential vary according to a speaker's ethnolinguistic identity. These complexities are particularly important for understanding the history and trajectory of the current reclamation movement for the Louisiana Creole language (aka “Kouri‐Vini”).
An Integrative Review of Exclusive Breast Milk Expression
Authors: Rosenbaum Kimberly , McAlister Barbara 
Published: December 2024

IntroductionA growing number of families are using exclusive breastmilk expression to feed their newborns. They need accurate information and support from their providers.MethodsThe purpose of this integrative review was to explore the prevalence, characteristics, practices, and outcomes of families who fed exclusively expressed breastmilk to their infants. The electronic databases of CINAHL, Scopus, PubMed, Web of Science, and article reference lists for articles on expressing human milk for infants were searched. Results were filtered to glean published studies between 2012 and 2022, academic journals, human studies, and English language journals while excluding secondary reviews and expert opinions. Both authors screened records within Covidence systematic review management software. Selected studies were evaluated for quality of evidence using the Johns Hopkins Research Evidence Appraisal Tool.ResultsTwenty‐seven studies were included in this review. Most families who exclusively expressed originally planned to directly breastfeed their newborns and only began pumping after encountering problems. The most frequently recurring theme was that advice from health care personnel was inconsistent. Women described a knowledge deficit and received more help with exclusive expression from informal social media groups than their providers. Prevalence of exclusive breastmilk expression is highest in Asian countries and in the neonatal intensive care unit environment. These women had a shorter duration of human milk feeding and higher likelihood of cessation compared with women who both fed expressed milk and directly breastfed.DiscussionOnly recently have breastfeeding researchers begun distinguishing the type of milk (human milk or artificial formula) from the feeding method in their publications. This approach allows clinicians to provide better guidance on the outcomes of each feeding method. As clinicians, we can help families by encouraging them and providing consistently accurate information. Solely feeding expressed human milk is a valid option when the lactating person is unable or unwilling to directly breastfeed.
Does cross‐fertilization occur in recent macroeconomics? A quantitative exploration of the interactions between DSGE and MAB models
Authors: Baccini Alberto , Cioni Martina , Dal Pont Legrand Muriel , Petrovich Eugenio 
Published: December 2024

AbstractThe dominant approach to macroeconomics has always claimed its capacity to incorporate new ideas, continuously adapting its models in order to address contemporaneous challenges. This narrative leads to present academic macroeconomics research as driven by a continuous linear progress. 2008 and its trail of crises seems to have revealed more openly that such interactions, to consider that they may have existed, may no longer operate. Focusing on recent period, we propose to challenge this narrative, investigating whether such interactions still exist today and questioning their nature. We established a set of 2299 articles composed by Dynamic Stochastic General Equilibrium (DSGE) models and Macro Agent‐Based Models (MABM). We investigate the structure of the social communities authoring these articles and their intellectual interactions in view of establishing their relative fragmentation or strong scientific unity. Bibliographic coupling reveals that DSGE and MABM literatures refer to two different sets of bibliographic references. We also pay attention to two communities known to be interstitial: HANKs and hybrid models. While the overall results exhibit a relative fragmentation of these communities, they do not provide evidence of collaboration between MABM and DSGE authors. Rather, results suggest a completely dissymmetric influence from DSGE on the MABM literature
Navigating Treatment‐Induced Head and Neck Malignancies in Cancer Survivors
Authors: Girardi Fábio Muradás , Pesenatto Gustavo Guthmann , Fuchs Larissa Dill , Maahs Thomas Peter , Treister Nathaniel S. , Maahs Gerson Schulz 
Published: December 2024

ABSTRACTCancer presents a significant global health burden. Traditional treatment modalities, especially radiotherapy and chemotherapy, have improved survival, but they have long‐term consequences. Treatment‐induced malignancies, a growing concern, pose risks to survivors. Often with limited treatment options, these tumors tend to have a worse survival rate. A thorough understanding of the main risk groups is critical for lifelong follow‐up and personalized care strategies. This review provides an update on the knowledge of treatment‐induced malignancies of the head and neck in cancer survivors; specifically, it discusses the risks, histological considerations, diagnosis and treatment strategies, follow‐up recommendations, and future perspectives.
Impact of the International Tumor Budding Consensus Conference Recommendations in Oral Cancer
Authors: Kopecka Katerina , Herman Michal , Michalek Jaroslav , Zapletalova Jana , Hermanova Marketa , Liptakova Priska , Hendrych Michal , Mozola Michal , Pink Richard 
Published: December 2024

ABSTRACTObjectivesTumor budding was suggested as a valuable prognostic factor in oral squamous cell carcinoma (OSCC) but lacks a standardized scoring system. This study evaluates tumor budding in OSCC using the scoring system recommended by the International Tumor Budding Consensus Conference (ITBCC) 2016.Materials and MethodsThe study included 114 patients with resected OSCC. Tumor budding was evaluated according to ITBCC criteria and assigned to three categories (low, intermediate, and high tumor budding). The associations between tumor budding and clinicopathological parameters were examined and survival rate analyses were performed by the Kaplan–Meier method. The prognostic value of tumor budding was assessed by Cox regression analysis.ResultsSignificant correlations of tumor budding with clinicopathological parameters including lymph node metastasis, grade, stage, perineural and lymphovascular invasion, and local recurrence were found. Intermediate and high tumor budding were significantly and independently associated with worse disease‐free survival. High tumor budding was identified as an independent prognostic factor for disease‐specific and overall survival.ConclusionsThe ITBCC scoring system represents a simple, feasible, and reproducible method to evaluate tumor budding in OSCC. Tumor budding, according to ITBCC criteria, showed its prognostic value in resected OSCC, and its incorporation into the histopathological reporting guidelines should be considered.
Intrinsic Capacity and Instrumental Activity of Daily Living Among Community Dwelling Elderly in China: The Mediating Effect of Two‐Way Social Support and Sense of Coherence
Authors: Hu Qingqing , Xu Jiajia , Ren Yifei , Ding Jie , Chu Ting 
Published: December 2024

ABSTRACTObjectivesTo explore the influence of intrinsic capacity (IC) on instrumental activities of daily living (IADL) among community‐dwelling elderly and to analyze the chain‐mediated effects of two‐way social support, and sense of coherence (SOC).DesignThis study was a cross‐sectional research design. Participants were recruited from September 2023 to December 2023 from Hangzhou City, Zhejiang Province, China, using a multistage sampling method.SampleParticipants in this study were at least 60 years old and had been currently living in the community for at least 1 year (n = 458).MeasurementsThe Integrated Care for Older People screening tool, the Brief Two‐Way Social Support Scale, the Sense of Coherence Scale‐13, and the Functional Activities Questionnaire were used to collect relevant data, which were statistically tested using structural equation modeling and multiple mediation effects.ResultsThere were correlations between IC, two‐way social support, SOC and IADL in community‐dwelling elderly (all p < 0.01). IC predicted two‐way social support (β = 0.570, p < 0.001), SOC (β = 0.544, p < 0.001) and IADL (β = −0.492, p < 0.001); two‐way social support had a positive predictive effect on SOC (β = 0.363, p < 0.001) but a negative predictive effect on IADL (β = −0.193, p < 0.001); SOC negatively predicted IADL (β = −0.150, p < 0.05).ConclusionsTo mitigate the impact of declining IC on IADL among community‐dwelling elderly, to sustain independent living, and to reduce the risk of progression to illness and disability, this study proposes two‐way social support and SOC as potential effective intervention targets. This conclusion holds implications for the assessment and intervention of elderly health, as well as the formulation of public health policies.
Glycomolecules: from “sweet immunity” to “sweet biostimulation”?
Authors: Boulogne I. , Mirande‐Ney C. , Bernard S. , Bardor M. , Mollet J.‐C. , Lerouge P. , Driouich A. 
Published: December 2024

AbstractClimate changes and environmental contaminants are daunting challenges that require an urgent change from current agricultural practices to sustainable agriculture. Biostimulants are natural solutions that adhere to the principles of organic farming and are believed to have low impacts on the environment and human health. Further, they may contribute to reducing the use of chemical inputs while maintaining productivity in adverse environments. Biostimulants are generally defined as formulated substances and microorganisms showing benefits for plant growth, yield, rhizosphere function, nutrient‐use efficiency, quality of harvested products, or abiotic stress tolerance. These biosolutions are categorized in different subclasses. Several of them are enriched in glycomolecules and their oligomers. However, very few studies have considered them as active molecules in biostimulation and as a subclass on their own. Herein, we describe the structure and the functions of complex polysaccharides, glycoproteins, and glycolipids in relation to plant defense or biostimulation. We also discuss the parallels between sugar‐enhanced plant defense and biostimulation with glycomolecules and introduce the concept of sweet biostimulation or glycostimulation.