bluuebunny/crossref_metadata_2025_split huggingface dataset:
Barriers and facilitators to the timely diagnosis of endometriosis in primary care in the Netherlands
Authors: van der Zanden Moniek , Teunissen Doreth A M , van der Woord Inger W , Braat Didi D M , Nelen Willianne L D M , Nap Annemiek W 
Published: July 2019

Abstract

Background
Endometriosis is an invalidating gynaecological condition in women of reproductive age, and a frequent cause of infertility. Unfortunately, the condition is characterized by a long interval between onset of symptoms and diagnosis. GPs in the Netherlands are educated to provide basic gynaecological care and serve as gatekeepers for specialist medical care. Therefore, it is of great importance that they recognize signs and symptoms possibly caused by endometriosis to initiate adequate actions.

Objective
The main objective of this study was to identify barriers and facilitators to the timely diagnosis of endometriosis from the GPs’ perspective.

Methods
Semi-structured focus group discussions with GPs were organized throughout the Netherlands. The participants were encouraged to brainstorm about their perspective on daily practice regarding endometriosis and suggestions for interventions to enable early diagnosis and treatment. Analysis was based on grounded theory methodology.

Results
Forty-three GPs participated in six focus groups. Analysis of the transcripts revealed relevant determinants of practice in four main themes: professionals’ experience and competence, patient characteristics, guideline factors and professional collaboration. A lack of knowledge and awareness appeared to result in a low priority for establishing the diagnosis of endometriosis, especially in young women. Infertility, patient engagement and a recent serious case or training facilitated referral.

Conclusion
Several factors in daily primary health care contribute to the diagnostic delay in endometriosis. Future interventions to reduce this delay may be aimed at increasing awareness by means of education, incorporating the subject into national clinical guidelines and improvements in interdisciplinary collaboration.
Defending sovereignty without collaboration: Vichy and the Italian Fascist threats of 1940–1942
Authors: Varley Karine 
Published: July 2019

Abstract
This article asks how Vichy sought to defend French sovereignty against Italian threats across those unoccupied areas of France and its colonial empire which were covered by the Italian armistice between June 1940 and November 1942. It suggests that, while Vichy’s response to German violations of French sovereignty was limited by its policy of collaboration, no such constraints were in place when it came to Italian interventions. Despite this, however, the defence of French sovereignty against Italian threats was not a straightforward story of defiance. Opposing Italian actions in one policy domain in one territory had to be weighed against the potential repercussions in another policy domain in another territory. It also had to be calibrated with the implications for French relations with Berlin. The Italian dimension to Vichy’s actions therefore suggests that the biggest challenge in negotiations was not Vichy’s desire to defend its sovereign status so much as the lure of collaboration.
Challenges, tactics and integrated management of emerald ash borer in North America
Authors: McCullough Deborah G 
Published: July 2019

AbstractEmerald ash borer (EAB) (Agrilus planipennis Fairmaire), discovered in southeastern Michigan, USA in 2002, has become the most destructive and costly invasive forest insect in North America. This phloem-boring beetle has also invaded Moscow, Russia and continued spread of EAB potentially threatens European ash (Fraxinus spp.) species. This review summarizes EAB life history, including interspecific variation in host preference, invasion impacts and challenges of detecting new infestations and provides an overview of available management tactics. Advances in systemic insecticides, particularly emamectin benzoate products applied via trunk injection, have yielded effective and practical options both to protect individual trees and to slow EAB population growth and ash decline on an area-wide basis without disrupting natural enemies. Economic costs of treating ash are substantially lower than removal costs, retain ecosystem services provided by the trees, reduce sociocultural impacts and conserve genetic diversity in areas invaded by EAB. Girdled ash trees are highly attractive to EAB adults in low-density populations and debarking small girdled trees to locate larval galleries is the most effective EAB detection method. An array of woodpeckers, native larval parasitoids and introduced parasitoids attack EAB life stages but mortality is highly variable. Area-wide management strategies that integrate insecticide-treated trees, girdled ash trap trees and biological control can be adapted for local conditions to slow and reduce EAB impacts.
Genes Related to Education Predict Frailty Among Older Adults in the United States
Authors: Huibregtse Brooke M , Newell-Stamper Breanne L , Domingue Benjamin W , Boardman Jason D 
Published: July 2019

Abstract

Objective
This article expands on research that links education and frailty among older adults by considering the role of genes associated with education.

Method
Data come from a sample of 7,064 non-Hispanic, white adults participating in the 2004–2012 waves of the Health and Retirement Study. Frailty was measured with two indices: (a) The Frailty Index which corresponds to a deficit accumulation model; and (b) The Paulson–Lichtenberg Frailty Index which corresponds to the biological syndrome/phenotype model. Genes associated with education were quantified using an additive polygenic score. Associations between the polygenic score and frailty indices were tested using a series of multilevel models, controlling for multiple observations for participants across waves.

Results
Results showed a strong and negative association between genes for education and frailty symptoms in later life. This association exists above and beyond years of completed education and we demonstrate that this association becomes weaker as older adults approach their 80s.

Discussion
The results contribute to the education–health literature by highlighting new and important pathways through which education might be linked to successful aging.
Lithospheric structure beneath the central and western North China Craton and adjacent regions from S-receiver function imaging
Authors: Zhang Yaoyang , Chen Ling , Ai Yinshuang , Jiang Mingming 
Published: July 2019

SummaryTo elucidate the nature and extent of the lithospheric modification in the central and western North China Craton (NCC) and adjacent regions, we used the wave equation–based migration technique of S-receiver function on teleseismic data collected from 314 broadband stations in this region to image the lithospheric structure. Incorporating data from previous lithospheric structure studies, we obtained unprecedented high-resolution depth maps of the lithosphere–asthenosphere boundary (LAB) and mid-lithospheric discontinuity (MLD) in the NCC. Our results show more detailed variations of the lithospheric thickness in the central and western NCC and adjacent regions, which ranges from 100 to >170 km, in marked contrast to the thinned lithosphere (60–100 km) in the eastern NCC. Despite its generally thick lithosphere (>130 km), the Ordos Block shows a concordant N–S difference from the surface to deep lithosphere with a boundary at the latitude of 37–38°N. The central NCC is laterally heterogeneous in the lithospheric structure, and the thick lithosphere (∼160 km) in the south is interpreted as a remnant cratonic mantle root. The central Qinling Orogenic Belt preserves a thick lithosphere (∼150 km), which may block the asthenospheric flow driven by extrusion of the Tibetan Plateau to the west of the NCC. Moreover, a negative MLD is widely identified at the depth of 80–110 km within the thick lithosphere, which corroborates the global existence of the MLD in continental regions. The consistence in the depth of the MLD and the shallow LAB in the eastern NCC supports the conjecture that the MLD may have played an important role in the lithospheric modification of the eastern NCC.
Anthropogenic seismicity as aftershocks for geo-resource production? Implications for Mmax estimates (reservoir impoundment cases)
Authors: Grasso J-R , Amorese D , Karimov A 
Published: July 2019

SUMMARYDeveloping a model for anthropogenic seismic hazard remains an open challenge whatever the geo-resource production. We analyse the (Mmax) largest reported magnitude on each site where (RTS) Reservoir Triggered Seismicity in documented (37 events, 1933–2008), for aftershocks of reservoir impoundment loading. We relate each reservoir impoundment to its magnitude-equivalent M*reservoir = M*(Lr). We use (Lr) the reservoir length as a proxy for a rupture length of the reservoir main shock-equivallent. This latter is derived from the empirical relationship that exists for tectonic earthquake among magnitude and rupture length. We resolve (i) Mmax for RTS are bounded by M*reservoir at a 95 per cent confidence level; (ii) in average Mmax are smaller than M*reservoir by 2.2 units (iii) 50 per cent of the Mmax occurrence is within 2 ± 1 yr from the reservoir impoundment. These triggering patterns support the signature of fluid driven seismicity during the slow reservoir impoundment emerges as a weaker efficiency (larger ΔM = M*reservoir – Mmax) to trigger Mmax events than from earthquake interactions.
A generalized Rytov approximation for accurate calculation of phase variation in strong perturbation media
Authors: Feng Bo , Wu Ru-Shan , Wang Huazhong 
Published: July 2019

SUMMARY
In the case of long-range propagation of forward scattering, due to the accumulation of phase changes caused by the velocity perturbations, the validity of the Born approximation will be violated. In contrast, the phase-change accumulation can be handled by the Rytov approximation, which has been widely used for long-distance propagation with only forward scattering or small-angle scattering involved. However, the weak scattering assumption (i.e. small velocity perturbation) in the Rytov approximation limits its scope of application. To address this problem, we analyse the integral kernel of the Rytov transform using the Wentzel-Kramers-Brillouin-Jeffreys (WKBJ) approximation and we demonstrate that the integral kernel is a function of velocity perturbation and scattering angle. By applying a small scattering angle approximation, we show that the phase variation has a linear relationship with the slowness perturbation, no matter how strong the magnitude of perturbation is. Therefore, the new integral equation is then referred to as the generalized Rytov approximation (GRA) because it overcomes the weak scattering assumption of the Rytov approximation. To show the limitations of the Rytov approximation and the advantages of the proposed GRA method, first we design a two-layer model and we analytically calculate the errors introduced by the small scattering angle assumption using plane wave incidence. We show that the phase (traveltime) variations predicted by the GRA are always more accurate than the Rytov approximation. Particularly, the GRA produces accurate phase variations for the normal incident plane wave regardless of the magnitude of velocity perturbation. Numerical examples using Gaussian anomaly models demonstrate that the scattering angle has a crucial impact on the accuracy of the GRA. If the small scattering angle assumption holds, the GRA can produce an accurate phase approximation even if the velocity perturbation is very strong. On the contrary, both the first-order Rytov approximation and the GRA fail to get satisfying results when the scattering angle is large enough. The proposed GRA method has the potential to be used for traveltime modelling and inversion for large-scale strong perturbation media.
Insights into local health and wellbeing policy process in Australia
Authors: Lilly Kara , Hallett Jonathan , Robinson Suzanne , Selvey Linda A 
Published: July 2019

Abstract
To investigate factors that enable or challenge the initiation and actioning of health and wellbeing policy in Australian local governments using political science frameworks. An online survey was distributed to staff and elected members of Australian local governments. The survey sought responses to a range of variables as informed by political science frameworks. Data were analysed using descriptive statistics and results were compared between local governments of different geographical sizes and locations using Kruskal–Wallis non-parametric testing. There were 1825 survey responses, including 243 CEOs, representing 45% of Australian local governments. Enablers for local government policy initiation and action included the high priority given to health and wellbeing (44%), local leadership (56%) and an organizational (70%) and personal obligation (68%) to the community to act. Less true is a favourable legislative environment (33%), leadership from higher levels of government (29%) and sufficient financial capacity (22%). Cities are better positioned to initiate and action health policy, regardless of the broader legislative environment. Health and wellbeing is a high priority for Australian local governments, despite lack of funding and limited lobbying and support from other sectors and higher levels of government. The insights from political science frameworks assist to understand the policy process, including the interrelatedness of enablers and challenges to initiating and actioning health and wellbeing policy. Further understanding the policy drivers would support practitioners and researchers advocating to influence local health and wellbeing policy.
Space-time analysis of unhealthy food advertising: New Zealand children’s exposure and health policy options
Authors: Liu Wei , Barr Michelle , Pearson Amber L , Chambers Tim , Pfeiffer Karin A , Smith Moira , Signal Louise 
Published: July 2019

Abstract
Reducing children’s exposure to unhealthy food advertising is an accepted strategy to end childhood obesity. This study aimed to (i) measure children’s space-time exposures to unhealthy food advertising in public outdoor spaces, using GPS and wearable cameras; and (ii) test effectiveness of banning options. We compiled data (collected July 2014—June 2015) on 138 12-year-old children in Wellington, New Zealand, using wearable cameras and GPS devices worn over 4 days. In 2017–18, we linked 59 150 images taken in public outdoor spaces to GPS data. Of these, 1631 contained unhealthy food advertising exposures, defined as ≥50% of an advertisement observed in each image. We examined spatial patterns using kernel density mapping and graphed space-time trends. We interpolated a kriged exposure rate across Wellington to estimate exposure reductions for potential bans. Children were exposed to 7.4 (95% CI 7.0–7.8) unhealthy food advertisements/hour spent in outdoor public spaces. Exposures occurred in shopping centres, residential areas and sports facilities, commonly involving fast food, sugary drinks and ice cream. Peak exposure times were weekend afternoons/evenings and weekdays before/after school. In Wellington, we estimated that banning such advertising within 400 m of playgrounds would yield a 33% reduction in exposure, followed by in residential areas (27%), within 400 m of schools (25%), and 50% for a ban combining all above. This work documents the extent of children’s exposure to unhealthy food advertising and the potential impact of bans. Given the ubiquity of advertising in public spaces, this New Zealand research offers innovative methods and findings likely relevant in other jurisdictions.
Progress in the genetic analysis of Parkinson’s disease
Authors: Singleton Andrew , Hardy John 
Published: July 2019

AbstractThe pace of genetic discovery in complex disease has accelerated exponentially over the last decade. Our fund of knowledge of the foundational genetics in disease has never been as great. There is a clear path forward to the resolution of the genetic architecture toward a point at which we will saturate the biological understanding of disease through genetics. This understanding continues to provide fundamental insights into disease biology and, with the advent of new data and methodologies, the path from gene to function is becoming clearer and cleaner. In this opinion piece, we discuss progress in the genetics of Parkinson disease. We explore what genetics has revealed thus far in the context of disease biology. We highlight mitophagy/autophagy, dopamine metabolism and the adaptive immune system. We try and link these findings together to give a holistic view of pathogenesis with the underlying theme that disease pathogenesis relates to a failure of damage response pathways. In the 1990s, Parkinson’s disease wa disorders and diseases. This review highlights recent advances in our understanding of the methylome's functionality and covers potential new roles for DNA methylation, their readers, writers, and erasers. Additionally, we examine novel insights into the relationship between the methylome, DNA–protein interactions, and their contribution to neurodegenerative diseases. Lastly, we outline the gaps in our knowledge that will likely be filled through the widespread use of newer technologies that provide greater resolution into how individual cell types are affected by disease and the contribution of each individual modification site to disease pathogenicity.
The technical risks of human gene editing
Authors: Davies Benjamin 
Published: July 2019

AbstractA recent report from Dr He Jiankui concerning the birth of twin girls harbouring mutations engineered by CRISPR/Cas nucleases has been met with international condemnation. Beside the serious ethical concerns, there are known technical risks associated with CRISPR/Cas gene editing which further raise questions about how these events could have been allowed to occur. Numerous studies have reported unexpected genomic mutation and mosaicism following the use of CRISPR/Cas nucleases, and it is currently unclear how prevalent these disadvantageous events are and how robust and sensitive the strategies to detect these unwanted events may be. Although Dr Jiankui’s study appears to have involved certain checks to ascertain these risks, the decision to implant the manipulated embryos, given these unknowns, must nonetheless be considered reckless. Here I review the technical concerns surrounding genome editing and consider the available data from Dr Jiankui in this context. Although the data remains unpublished, preventing a thorough assessment of what was performed, it seems clear that the rationale behind the undertaking was seriously flawed; the procedures involved substantial technical risks which, when added to the serious ethical concerns, fully justify the widespread criticism that the events have received.
A Population-Based Study of Combination vs Monotherapy of Anti-TNF in Persons With IBD
Authors: Elias Evan D , Targownik Laura E , Singh Harminder , Bernstein Charles N 
Published: July 2019

Abstract

Background
Few data exist about the utilization of combination therapy (anti–tumor necrosis factor [anti-TNF] plus immunosuppressives) in clinical practice. We assessed the prevalence and predictors of combination therapy use vs anti-TNF monotherapy in inflammatory bowel disease (IBD) in the Canadian province of Manitoba.

Methods
All 23 prescribers of anti-TNF medications for IBD in Manitoba facilitated chart review of their comprehensive lists of adult anti-TNF patients from 2005 to 2015. Subjects were stratified by year of first anti-TNF exposure. Patient, disease, and prescriber factors influencing combination therapy use were explored.

Results
A total of 774 patients met inclusion criteria. Seventy-one point one percent had Crohn’s disease (CD), 28.3% had ulcerative colitis (UC), and 0.6% had IBD unclassified; 45.3% received combination therapy, with no difference between CD and UC. Crohn’s disease subjects receiving combination therapy were more likely to have penetrating or perianal disease (56.9% vs 42.8%; P = 0.001) and less likely to have had previous IBD-related surgeries (36.2% vs 46.2%; P = 0.02). The median age at diagnosis and at anti-TNF initiation was lower among combination therapy users. Adalimumab users were as likely as infliximab users to receive combination therapy but persisted with treatment for a shorter time. The proportion of new anti-TNF users receiving combination therapy did not change over time (P = 0.43). There was substantial variation in combination therapy use between prescribers (P = 0.002). The most frequently encountered reasons for avoiding combination therapy were previous intolerance or ineffectiveness of immunosuppressive monotherapy.

Conclusion
Use of combination therapy has remained unchanged over time despite the publication of high-quality data supporting its efficacy over anti-TNF monotherapy.
Beyond the Powerhouse: Integrating Mitonuclear Evolution, Physiology, and Theory in Comparative Biology
Authors: Havird Justin C , Weaver Ryan J , Milani Liliana , Ghiselli Fabrizio , Greenway Ryan , Ramsey Adam J , Jimenez Ana G , Dowling Damian K , Hood Wendy R , Montooth Kristi L , Estes Suzanne , Schulte Patricia M , Sokolova Inna M , Hill Geoffrey E 
Published: July 2019

Abstract
Eukaryotes are the outcome of an ancient symbiosis and as such, eukaryotic cells fundamentally possess two genomes. As a consequence, gene products encoded by both nuclear and mitochondrial genomes must interact in an intimate and precise fashion to enable aerobic respiration in eukaryotes. This genomic architecture of eukaryotes is proposed to necessitate perpetual coevolution between the nuclear and mitochondrial genomes to maintain coadaptation, but the presence of two genomes also creates the opportunity for intracellular conflict. In the collection of papers that constitute this symposium volume, scientists working in diverse organismal systems spanning vast biological scales address emerging topics in integrative, comparative biology in light of mitonuclear interactions.