bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exploring the Lapse in Druggability: Sequence Analysis, Structural Dynamics and Binding Site Characterization of K-RasG12C Variant, a Feasible Oncotherapeutics Target
Authors: Adeniji Emmanuel A. , Olotu Fisayo A. , Soliman Mahmoud E.S. 
Published: July 2018

Background:The difficulty in druggability of K-Ras variant has presented a challenge in the treatment of cancer diseases associated with its dysfunctionality. Despite the identification of different binding sites, limited information exists in the literature about their characteristics. Therefore, identification, crossvalidation and characterization of its druggable sites would aid the design of chemical compounds that will arrest its dysfunctionality related oncogenesis.Objective:This study entails the identification, cross-validation and characterization of K-Ras G12C variant’s binding sites for potential druggability, coupled with the elucidation of alterations in 3D conformations and dynamics.Method:Molecular dynamics simulation was carried out on the inactive, the active and the hyperactive K-RasG12Cvariant using the amber software package. The SiteMap software was employed in identifying and characterizing the druggable binding sites while the validation of the binding sites was carried out with the SiteHound and MetaPocket servers.Results:Four druggable binding sites were identified, validated and characterized based on physicochemical attributes such as size, volume, degree of enclosure or exposure, degree of contact, hydrophobic/hydrophilic character, hydrophobic/hydrophilic balance and hydrogen-bonding features. Conformational studies also revealed that the K-Ras variant exhibited notable structural instability, increased flexibility and a strongly anticorrelated movement compared to the inactive and active wildtype forms.Conclusion:The attributes of the characterized druggable sites will be useful in designing site-specific K-Ras inhibitors for the treatment of K-Ras variant associated cancer diseases.
Indikator sekolah kreatif
Authors: Nurhayati Riana 
Published: July 2018

Penelitian ini bertujuan untuk mengetahui indikator Sekolah Kreatif di Sekolah Dasar (SD). Penelitian ini menggunakan metode kualitatif. Subjek penelitian adalah kepala sekolah dan guru SD Muhammadiyah 16 Surabaya (Sekolah Kreatif). Analisa data dengan reduksi, kategorisasi dan intepretasi. Hasil penelitian menunjukkan bahwa indikator yang bisa dicapai oleh sekolah untuk membuat sekolah lebih kreatif adalah pengembangan sistem gagasan dan ide, pengembangan sistem sosial dalam aktivitas belajar, dan penciptaan sistem lingkungan sekolah yang sinergis antar unsur sekolahKata kunci: sekolah kreatif THE INDICATORS OF CREATIVE SCHOOLAbstractThis research is aimed at revealing the indicators of creative school in emelentary schools. The study employed qualitative method, and the subject of the research was the principal and teachers of Muhammadiyah 16 Surabaya Elementary School (a creative school). The data were analyzed by applying reduction, categorization, and interpretation. The result of the research shows that the indicators which can be attained by elementary school in order to contrive a creative school are developing the concept and idea systems, developing social system in learning activity, and creating synergetic school elements at the school environment system.Keywords: creative school
Assessing the Efficacy of Mobile Health Apps Using the Basic Principles of Cognitive Behavioral Therapy: Systematic Review (Preprint)
Authors: Rathbone Amy Leigh , Clarry Laura , Prescott Julie 
Published: July 2018

BACKGROUND

Cognitive behavioral therapy (CBT) in its basic principle has developed itself as a stand-alone, substantial method of therapy. With effective application in therapy for a range of mental health issues, the spread of CBT methods to Web-based therapy sources is evident. The development of mobile phone apps using CBT principles is increasing within the research area. Despite the move to Web-based methods of therapy, it is argued that these methods lack the same efficacy of face-to-face therapy sessions.

OBJECTIVE

The aim of this review was to assess extent research findings with regard to the effectiveness of CBT-related mobile health (mHealth) apps. By assessing only studies employing a randomized controlled trial design, the review aimed to determine app efficacy within the highly regarded method of investigation.

METHODS

A comprehensive literature search was conducted across several databases. Search results were filtered, and results were subject to strict inclusion and exclusion criteria because of the nature of the review. Where possible, analysis of effect size was calculated and results reported.

RESULTS

A total of 8 studies investigating the effectiveness of mHealth CBT-related apps across a range of mental health issues were reviewed. Three studies used the app against a control group, and 5 studies used the app intervention against another form of treatment or intervention. A range of effect sizes were seen across all included studies (d=−0.13 to 1.83; 0.03-1.44), with the largest effects often being seen when comparing the data from pre- to posttest for the app engaged group.

CONCLUSIONS

The studies reviewed support the use of mHealth apps containing CBT principles for a range of mental health issues. However, the effectiveness over longer time periods should be assessed. Researchers and professionals should seek to collaborate effectively when creating new apps to enhance their effectiveness as a treatment for the general public.
Perancangan Lingkungan Fisik Dengan Pendekatan Green Building
Authors: Yuliyanti Y 
Published: July 2018

PG Tjoekir is a sugar manufactured by PTPN X BUMN, sugar production trough 6 phase where each has many problem about physic environment ( health and comfort). Each room has environment with noisy level a 85 dBA, exposure level a 200 lux and temperature level a 36°C. So these problem has need design repair for environment physic with Green Building methods. This methods can be reduce noisy level, exposure level and temperature level. For arelaize health abd comfort workroom to emloyees. The result of reserch has obtainable a design 4 exhaust fan, 4 exhaust, 3 turbin ventilation, 4 LED lamp and 3 Regupol vibration metal. About the design realize can reduce of temperature room 0,73 m/s and 44 dBA for noisy level.
PROBLEM OF INTOLERANCE TOWARDS CONVICTS AND WAYS OF SOLUTIONS
Authors: Lisowski Piotr , Panchenko Mykola , Rekun Viktor 
Published: July 2018

The article analyzes the problem of intolerance towards convicted persons, in particular, the concept, the meaningful signs and possible approaches of its minimization. The research is carried out in a comparative mode and based upon the norms of the current legislation of Ukraine and Poland. The researchers dwell upon key aspects of social adaptation of former convicts. The emphasis is made on the experience of the European Union in effective using "probation" as a way to minimize the intolerance towards former prisoners in society.
Women newspaper editors in NZ: Short term love affair
Authors: Strong Catherine 
Published: July 2018

New Zealand has had three women prime ministers, and the first country in the world to give women a vote, but there is still a gender gap in leadership in the traditionally staid arena of daily newspapers. One-third of the country’s daily newspapers have never had a female editor. The gender imbalance is significant in an industry that still breaks the majority of news items, and is influential in public information. The low ratio of women editors is incongruous with the fact the majority of journalism students are female, and a large number new hires are women. This longitudinal study has interviewed every woman who has held the position of editor, which totals only 15. The good news is that currently there are more women in editorships than ever before, the sad news is that this still represents only 29 percent of daily editors. The attitudinal interviews show the editors love the job, but quit after only a few short years, but this may be changing.
REVIEW: Intervention in Aboriginal communities examined
Authors: Mason Bonita 
Published: July 2018

‘And there’ll be NO dancing’: Perspectives on policies impacting Indigenous Australia since 2007, edited by Elisabeth Baehr and Barbara Schmidt-Haberkamp. Cambridge, UK: Cambridge Scholars Publishing, 2017. 354 pp. ISBN 9781443898638
‘THE PAST is now with us; it never went away.’
The 2007 Intervention into the lives of Aboriginal people living in the Northern Territory was a low point in the relationship between the Australian government and Indigenous people. As one of the Aboriginal authors in No Dancing, Warraimay historian Victoria Grieves puts it, the Northern Territory Emergency Response (NTER), as the Intervention was officially known, ‘leaves no doubt about the relationship of Aboriginal people to the settler colonial state’ (p. 89).
Bearing Witness 2017: Year 2 of a Pacific climate change storytelling project
Authors: Robie David 
Published: July 2018

In 2016, the Pacific Media Centre responded to the devastation and tragedy wrought in Fiji by Severe Tropical Cyclone Winston by initiating the Bearing Witness journalism project and dispatching two postgraduate students to Viti Levu to document and report on the impact of climate change (Robie & Chand, 2017). This was followed up in 2017 in a second phase of what was hoped would become a five-year mission and expanded in future years to include other parts of the Asia-Pacific region. This project is timely, given the new 10-year Strategic Plan 2017-2026 launched by the Secretariat of the Pacific Regional Environment Programme (SPREP) in March and the co-hosting by Fiji of the UN Framework Convention on Climate Change (COP23) climate change conference in Bonn, Germany, during November. The students dispatched in 2017 on the ‘bearing witness’ journalism experiential assignment to work in collaboration with the Pacific Centre for the Environment and Sustainable Development (PaCE-SD) and the Regional Journalism Programme at the University of the South Pacific included a report about the relocation of a remote inland village of Tukuraki. They won the 2017 media and trauma prize of the Asia-Pacific Dart Centre, an agency affiliated with the Columbia School of Journalism. This article is a case study assessing the progress with this second year of the journalism project and exploring the strategic initiatives under way for more nuanced and constructive Asia-Pacific media storytelling in response to climate change.
Retrospective survey of owners' experiences with palliative radiation therapy for pets
Authors: Fan Vivian C. , Mayer Monique N. , Sukut Sally L. , Gustafson Nancy R. , Mauldin G. Neal , Waldner Cheryl L. 
Published: July 2018

Abstract
OBJECTIVE To describe animal owners' experiences with palliative radiation therapy (PRT) of pets and identify factors influencing satisfaction with their pets' treatment.
DESIGN Retrospective, cross-sectional study.
SAMPLE 118 owners of dogs, cats, or rabbits.
PROCEDURES Medical records were searched to identify animals that underwent PRT between 2004 and 2013. Signalment, tumor-related data, and outcome information were recorded. Owners completed an electronic survey assessing satisfaction with treatment (ie, satisfaction with the decision for their pet to undergo PRT and indication that they would choose PRT for their pet again), expectations regarding PRT, and perceptions of their pets' quality of life (QOL) and signs of discomfort from acute adverse radiation effects. Additional data regarding practical aspects of treatment, pet death, communications with veterinarians, and owner demographics were collected. Variables were tested for association with measures of owner satisfaction.
RESULTS 92 of 116 (79%) owners were satisfied with the decision to have their pets undergo PRT. Most (92/118 [78%]) owners reported their pet's QOL improved after PRT; these owners were significantly more likely to be satisfied than those who did not report improved QOL. Owners who perceived their pets had discomfort from adverse radiation effects (38/116 [33%]) were significantly less likely to be satisfied than owners who did not report this observation. Measures of satisfaction were not associated with patient survival time. Twenty-one of 118 (18%) owners indicated they expected PRT would cure their pet's tumor.
CONCLUSIONS AND CLINICAL RELEVANCE Results suggested that short life expectancy should not deter recommendation of PRT for pets. Protocols that minimize risk of acute adverse effects may be advantageous. Veterinarians should attempt to ensure that owners understand the goals of PRT.
Survey of human-horse relationships and veterinary care for geriatric horses
Authors: Mueller Megan Kiely , Sween Carolyn , Frank Nicholas , Paradis Mary Rose 
Published: July 2018

Abstract
OBJECTIVE To assess relationships between horse owners (or lessees) and geriatric or nongeriatric horses and to investigate factors influencing veterinary care decision-making.
DESIGN Descriptive, cross-sectional, survey-based study.
SAMPLE 2,879 people who owned or leased ≥ 1 horse.
PROCEDURES Participants were recruited through social media and online horse forums to participate in an online survey about their horses, including measures of attachment, veterinary care decision-making, and experiences surrounding the death of a horse. Data were collected for primary horses (those respondents interacted with most) and secondary horses. Horses were further categorized as geriatric (≥ 20 years of age) and nongeriatric.
RESULTS Geriatric primary horses were considered companion animals, retired, or used as part of a business significantly more frequently, and described as competition horses significantly less frequently, than nongeriatric horses. Geriatric horses were owned or leased significantly longer than nongeriatric horses, but the degree of respondents' attachment did not differ for geriatric versus nongeriatric horses. When respondents reported the death of a horse in the previous year, euthanasia was associated with higher levels of bereavement than death by other means. Death of geriatric horses most commonly followed a chronic illness and was associated with significantly higher levels of bereavement than death of nongeriatric horses. Among factors influencing decisions regarding expensive or long-term medical care, the horse's ability to lead a comfortable life was ranked highest. Respondents with geriatric horses made numerous accommodations for their care.
CONCLUSIONS AND CLINICAL RELEVANCE Results provided important initial information about the relationships people have with geriatric horses. Understanding how individuals perceive their horses and how they make decisions regarding complex veterinary care is critical in informing effective client communication.
Clients' attitudes toward veterinarians' attire in the small animal emergency medicine setting
Authors: Sugerman-McGiffin Tyler , Hybki Gabrielle C. , Castro Jesse , Murphy Lisa A. , Tansey Colleen , Patlogar Jeffrey E. , Nakamura Reid K. , Chen Dillon Y. 
Published: July 2018

Abstract
OBJECTIVE To determine how veterinarians' attire affected clients' perceptions and trust in the small animal emergency medicine setting.
DESIGN Cross-sectional study.
SAMPLE 154 clients of a 24-hour small animal emergency clinic in a rural location.
PROCEDURES A survey was administered to clients in the waiting room over a 1-month period to elicit their impressions of veterinarians' attire in various clinical scenarios and whether that attire would affect their perceptions. Respondents completed the survey after examining photographs of 1 male and 1 female veterinarian in 5 styles of attire (business, professional, surgical, clinical, and smart casual).
RESULTS 83 (53.9%) respondents were female, and 71 (46.1%) were male; age was evenly distributed. Across all clinical scenarios, the most common response was no preference regarding the way a male or female veterinarian was dressed and that this attire would have no effect on the respondents' trust in their veterinarian. Most respondents were indifferent or preferred that their veterinarians not wear neckties and white coats. Twenty-six percent (40/154) of respondents indicated that they believed their veterinarian's attire would influence their opinion of the quality of care their pet received.
CONCLUSIONS AND CLINICAL RELEVANCE In this small animal emergency medicine setting, most clients indicated no preference regarding their veterinarian's attire, yet approximately one-fourth indicated this attire would influence their perception of the quality of care their pet received. Further studies are warranted in other practice settings and locations to determine whether these findings are generalizable or unique to this particular setting.
Eco-Economics in Cities and Rural Areas
Authors: Zvirgzdiņš Jānis , Plotka Kaspars , Geipele Sanda 
Published: July 2018

Abstract
Economic models are built primarily following the classical economic theories, but a challenge to build good models with classical theories is needed to define the exact value of the Earth, which is hardly definable. Quite often national gross product indicator calculation reuses the same performance indicators, where the resource and income distribution system is not linked to production factors. The resource and income distribution system is primarily associated with low productivity (execution of a sales plan, execution of a profit plan, profitability level, increase in market share, personnel turnover rate, hours worked per employee). Changes in the productive and economic structures of the markets result in new innovative growth patterns which, based on customer motivation, are linked to the concentration of capital in regional and national markets, the growth of transnational markets and the development of technology. At the same time, extensive economic development through natural resources leads to deforestation, landscape changes, desertification, swamping and soil fertility renewal. So far, it often has been assumed that economic growth depends on the use of natural resources, and natural resources are unlimited. The results are “resource crisis”: resources are running out and resource prices are rising, thus invalidating a particular model. On the other hand, the eco-economy approach is a sustainable future for the economic modelling. The principle of eco-economy is based on a production system, which relies on re-cyclicality (the basis is the production of zero waste production). For this to happen, a transition to a completely new mind-set is needed. The research results were previously approbated during the graduate meeting of the Baltic DBU scholarship holders from 4 to 6 May 2018 in Latvia.
Development of Public Administration and Governance in Central and Eastern Europe: Content Analysis of The NISPAcee Journal
Authors: Kotnik Žiga , Kovač Polonca 
Published: July 2018

Abstract
Public administration (PA) as a discipline and public governance as a closely related concept have been developing constantly and rather rapidly in recent years. A particularly lively progress is characteristic of Central and Eastern Europe (CEE), owing to its post-communist legacy and subsequent transition. This paper outlines the mainstream topics of PA development within The NISPAcee Journal, which covers the CEE region and beyond. The principal objective of the paper is to systematically and quantitatively codify a series of text documents that comprises 142 articles published between 2008 and 2016 in The NISPAcee Journal, in order to identify the characteristics of PA development in the region. The paper investigates three hypotheses: first, whether the quality of the articles changed throughout 2008 – 2016; second, whether The NISPAcee Journal attests a multidisciplinary orientation in terms of scientific contributions from different disciplines, and third, whether The NISPAcee Journal reflects the West-East knowledge transfer among PA academia. The three hypotheses were tested against seven analytical dimensions. The research findings reveal that governance is the prevailing cognitive paradigmatic approach of The NISPAcee Journal. Europeanisation is the common thread of almost all articles, with a particular emphasis on the ideological elements of the Neo-Weberian and New Public Management doctrines. Qualitative methodology is still the prevailing research method, and the occurrence of mixed methodology is rare. The topical orientation of the analysed manuscripts is very diverse. A considerable emphasis is placed on the analysis and development of PA as a discipline. The majority of researchers originate from CEE countries and focus their studies on Eastern Europe, the Balkans, and the Caucasus. Scientific partnership between the Eastern and the Western academic worlds is still scarce. Given the low level of exchange of best academic practices between Western and Eastern Europe, research results indicate the need for an increased internationalisation of the NISPAcee Journal and a more holistic approach to tackle the future challenges of global and regional PA and public governance more adequately.
Recreational Development in the Settlements of the Warta Valley in Wielkopolska
Authors: Januchta-Szostak Anna , Karaśkiewicz Agata 
Published: July 2018

Abstract
Riverside areas have substantial recreational and tourist assets, but their potential in the settlements of Wielkopolska is underused due to difficult access to the river and the poor development of the embankments. The aim of the research is to analyse the functional-spatial structure and the development of River Warta areas in the settlements of Wielkopolska with respect to their usefulness in recreation. Particular attention is paid to accessibility and the location of recreational infrastructure in the Warta Valley. Out of the eleven Wielkopolska settlements which were included, only in four – Konin, Śrem, Poznań and Sieraków – had sections of embankment boulevards been built. In the riverside areas there are few recreational facilities used in connection with the close proximity of the river. However, a great tourist asset of the Warta Valley is the Great Waterway Loop of Wielkopolska, which operates successfully due to the growing number of harbours and marinas in all the settlements included in the study.
ARKEOLOGI, PUBLIK DAN MEDIA SOSIAL DI MALUKU
Authors: Ririmasse Marlon NR 
Published: July 2018

Media sosial telah menjadi wahana yang bertautan dengan hampir seluruh aspek kehidupan manusia saat ini. Mulai dari ranah teknologi informasi hingga segmen kebudayaan. Termasuk dalam disiplin arkeologi. Sudah lebih dari dua dekade, media sosial tidak saja menjadi ruang informal perjumpaan dan pertukaran gagasan, namun telah menjelma menjadi motor efektif yang turut menggerakkan dinamika akademis disiplin arkeologi. Termasuk menjadi agen bagi interaksi arkeologi dan masyarakat. Media sosial berperan sebgai salah satu ruang paling efektif dalam meluaskan pengetahuan arkeologi bagi publik. Termasuk di Maluku. Makalah ini mencoba mengamati hubungan disiplin arkeologi dan media sosial bagi perluasan pengetahuan arkeologi dan sejarah budaya untuk masyarakat di Maluku. Metode yang digunakan adalah kajian pustaka. Hasil studi menemukan bahwa media sosial telah menjadi salah satu agen utama dalam publikasi pengetahuan arkeologi di Maluku dan prospektif untuk terus dikembangkan ke depan. Kata kunci: Arkeologi, Publik, Media Sosial, Maluku