bluuebunny/crossref_metadata_2025_split huggingface dataset:
A generative artificial intelligence approach for antibiotic optimization
Authors: Torres Marcelo D. T. , Zeng Yimeng , Wan Fangping , Maus Natalie , Gardner Jacob , de la Fuente-Nunez Cesar 
Published: November 2024

AbstractAntimicrobial resistance (AMR) poses a critical global health threat, underscoring the urgent need for innovative antibiotic discovery strategies. While recent advances in peptide design have yielded numerous antimicrobial agents, optimizing these molecules experimentally remains challenging due to unpredictable and resource-intensive trial-and-error approaches. Here, we introduce APEX Generative Optimization (APEXGO), a generative artificial intelligence (AI) framework that integrates a transformer-based variational autoencoder with Bayesian optimization to design and optimize antimicrobial peptides. Unlike traditional supervised learning approaches that screen fixed databases of existing molecules, APEXGOgenerates entirely novel peptide sequences through arbitrary modifications of template peptides, representing a paradigm shift in peptide design and antibiotic discovery. Our framework introduces a new peptide variational autoencoder with design and diversity constraints to maintain similarity to specific templates while enabling sequence innovation. This work represents the firstin vitroandin vivoexperimental validation of generative Bayesian optimization in any setting. Using ten de-extinct peptides as templates, APEXGOgenerated optimized derivatives with enhanced antimicrobial properties. We synthesized 100 of these optimized peptides and conducted comprehensivein vitrocharacterizations, including assessments of antimicrobial activity, mechanism of action, secondary structure, and cytotoxicity. Notably, APEXGOachieved an outstanding 85% ground-truth experimental hit rate and a 72% success rate in enhancing antimicrobial activity against clinically relevant Gram-negative pathogens, outperforming previously reported methods for antibiotic discovery and optimization. In preclinical mouse models ofAcinetobacter baumanniiinfection, several AI-optimized molecules—most notably derivatives of mammuthusin-3 and mylodonin-2—exhibited potent anti-infective activity comparable to or exceeding that of polymyxin B, a widely used last-resort antibiotic. These findings highlight the potential of APEXGOas a novel generative AI approach for peptide design and antibiotic optimization, offering a powerful tool to accelerate antibiotic discovery and address the escalating challenge of AMR.
Resting-state functional connectivity and fast spindle temporal organization contribute to episodic memory consolidation in healthy aging
Authors: Hamel Anaïs , Champetier Pierre , Rehel Stéphane , André Claire , Landeau Brigitte , Mézenge Florence , Haudry Sacha , Roquet Daniel , Vivien Denis , de La Sayette Vincent , Chételat Gaël , Rauchs Géraldine , Mary Alison ,   the Medit-Ageing Research group
Published: November 2024

AbstractEpisodic memory consolidation relies on the functional specialization of brain networks and sleep quality, both of which are affected by aging. Functional connectivity during wakefulness is crucial to support the integration of newly acquired information into memory networks. Additionally, the temporal dynamics of sleep spindles facilitates overnight memory consolidation by promoting hippocampal replay and integration of memories within neocortical structures. This study aimed at exploring how resting-state functional connectivity during wakefulness contributes to sleep-dependent memory consolidation in aging, and whether spindles clustered in trains modulates this relationship.Forty-two healthy older adults (68.82 ± 3.03 years), enrolled in the Age-Well clinical trial, were included. Sleep-dependent memory consolidation was assessed using a visuo-spatial memory task performed before and after a polysomnography night. Resting-state functional connectivity data were analyzed using graph theory applied to the whole brain, specific brain networks and the hippocampus.Lower limbic network integration and higher centrality of the anterior hippocampus were associated with better memory consolidation. Spindle trains modulated these effects, such that older participants with longer spindle trains exhibited a stronger negative association between limbic network integration and memory consolidation.These results indicate that lower functional specialization at rest is associated with weaker memory consolidation during sleep. This aligns with the dedifferentiation hypothesis, which posits that aging is associated with reduced brain specificity, leading to less efficient cognitive functioning. These findings reveal a novel mechanism linking daytime brain network organization and sleep-dependent memory consolidation, and suggest that targeting spindle dynamics could help preserve cognitive functioning in aging.
Gustatory sensitivity to amino acids in bumblebees
Authors: Rossoni Sergio , Parkinson Rachel H. , Niven Jeremy E. , Nicholls Elizabeth 
Published: November 2024

AbstractBees rely on amino acids from nectar and pollen for essential physiological functions. While nectar typically contains low (<1 mM) amino acid concentrations, while their levels in pollen are higher, but vary widely (10-200 mM). Behavioural studies suggest bumblebees have preferences for specific amino acids but whether such preferences are mediated via gustatory mechanisms remains unclear. This study explores bumblebees’ (Bombus terrestris) gustatory sensitivity to two essential amino acids (EAAs), valine and lysine, using electrophysiological recordings from gustatory sensilla on their mouthparts. Valine elicited a concentration-dependent response from 0.1 mM, indicating that bumblebees could perceive valine at concentrations found naturally in nectar and pollen. In contrast, lysine failed to evoke a response across tested concentrations (0.1-500 mM). The absence of lysine detection raises questions about the specificity and diversity of amino acid-sensitive receptors in bumblebees. Bees responded to valine at lower concentrations than sucrose, suggesting comparatively higher sensitivity (EC50: 0.7 mMvs. 3.91 mM for sucrose). Our findings indicate that bumblebees can rapidly evaluate the amino acid content of pollen and nectar using pre-ingestive cues, rather than relying on post-ingestive cues or feedback from their nestmates. Such sensory capabilities likely impact foraging strategies, with implications for plant-bee interactions and pollination.
Stigma management: a counter-accounting of child labour and environmental issues in the mining sector
Authors: Khalid Sharif Mahmud , Uche Chinyere O. 
Published: November 2024

PurposeLarge mining companies are often subject to stigmatisation. Thus, these companies try to shift stigma to artisanal small-scale miners in stigma management. This study seeks to understand why and how these mining companies use corporate reporting in shifting stigma.Design/methodology/approachThis is a qualitative study that combines data collected from semi-structured interviews, focus group and secondary documents.FindingsThe findings suggest that large mining companies involved in shifting stigma use corporate reporting to promote a positive image and avoid investor discrimination. Artisanal small-scale miners are targeted because of their vulnerability to stereotyping and discrimination. The findings suggest that mining companies shift stigma by blaming and shaming artisanal small-scale miners for child labour, human endangerment and environmental damage in reporting. The work of these miners is abnormalised as violating moral order. It is observed that the information provided in corporate reporting is often decontextualised from reality.Originality/valueThis paper makes an original contribution to accounting studies by showing how corporate reporting is used in counter-accounting in the context of stigma management. Counter-accounting as a form of stigma management is operationalised through the blaming and shaming of artisanal small-scale miners.
Exploring dynamics of stakeholder salience and functional roles in megaproject collaborative innovation system: insights from the Hong Kong-Zhuhai-Macao Bridge
Authors: Chen Xiaoyan , Liu Yan , Locatelli Giorgio , He Qinghua , Zhang Xinyue 
Published: November 2024

PurposeMegaprojects provide an ideal context for exploring the dynamic characteristics of stakeholders within a collaborative innovation system. This research aims to examine the changes in stakeholder salience and functional roles during the evolution of such a system.Design/methodology/approachThis study is empirically grounded on the Hong Kong-Zhuhai-Macao Bridge (HZMB) megaproject in China, analyzed with the stakeholder salience, stakeholder functional role, stakeholder dynamics and collaborative innovation system theoretical lens.FindingsThe megaproject collaborative innovation system can be divided into four stages: the birth stage, development stage, mature stage and re-innovation stage. Stakeholder salience generally remains unchanged throughout the lifecycle of the collaborative innovation system, except for engineering consulting firms (ECF). ECF transitioned from a definitive stakeholder to an expectant stakeholder upon project completion. The number of definitive stakeholders during the first three stages increases gradually. Besides, stakeholder functional roles shift in eight different directions throughout the lifecycle of the megaproject collaborative innovation system because they possess different core resources necessary for implementing innovations and are positioned differently within the collaborative innovation system.Originality/valueThis study contributes to the theory and practice of collaborative innovation in megaprojects. First, it offers insights into the evolution of megaproject collaborative innovation systems from the perspective of stakeholder interactions. Second, it has significant implications for managing stakeholder relationships based on their salience and functional roles at different stages of the collaborative innovation system.
Facilitating entrepreneurship in higher education through practitioner integration: a closer look at the “entrepreneur in residence” initiative
Authors: Aluthgama-Baduge Chinthaka , Rajasinghe Duminda , Ilonen Sanna , Gilman Mark 
Published: November 2024

PurposeWe investigate practitioner integration (PI) within higher education institutions (HEIs) by taking a closer look at the entrepreneur in residence (EiR) initiative. Engaging experienced entrepreneurs through EiR initiatives to facilitate entrepreneurship education (EE) has become a familiar PI model within HEIs; nevertheless, how EiRs perceive their role and integration in academia has been under-researched. We deepen the understanding of how EiRs facilitate EE and their role and fit into academia.Design/methodology/approachThis qualitative research employs interpretative phenomenological analysis (IPA) as the methodology. Following IPA guidance, we purposively selected seven EiRs working within HEIs and conducted one semi-structured interview with each participant. The data were analysed using IPA data analysis guidelines.FindingsThe findings suggest that the previous experiences of EiRs influence their confidence, skills and intrinsic motivation in their role in academia. EiRs play a multifaceted role that goes beyond students and simple educational activities to develop trust and understanding among university communities while bridging academic–practitioner, structural and communication gaps that hinder entrepreneurship in higher education. The study reveals the disconnected nature of EiRs’ role in academia and the tensions between academics and EiRs.Originality/valueThis study provides space for unheard EiRs’ voices, enriching the scarce EiR literature by advancing our knowledge about their role and fit in academia. The novel insights into the role of EiRs broaden the scope of EE to university communities beyond students. The findings deepen our understanding of how EiRs foster entrepreneurship by acting as a trust ladder and developing a networked approach to supporting university stakeholders. The challenges lie in how EiRs are integrated and the tensions between academics and practitioners. We also found that EiRs with greater authority, prior exposure to strategic roles within the institution and strong relationships with institutional leaders perform their role efficiently. Hence, this study establishes the importance of a more coordinated, strategic approach to PI within HEIs.
Factors affecting the adoption of energy efficiency measures across business enterprises in India
Authors: Ali Jabir , Shah Farah Farooq 
Published: November 2024

Purpose
This study aims to analyse the factors affecting the adoption of energy efficiency measures (EEMs), like energy conservation and management, heating and cooling improvements and improvements to lighting systems across business enterprises.

Design/methodology/approach
Analytical techniques such as descriptive statistics, chi-square test and logistic regression with marginal effect have been used on the World Bank Enterprise Survey 2022 data covering 9,374 firms in India to make the necessary inferences.

Findings
Analysis indicates that about 79.7 % firms have reported the adoption of at least one EEM. The chi-square statistics show that medium manufacturing firms with higher age, having female ownership, belonging to bigger cities, spending on R&D, taking credit from financial institutions and having international quality certification are comparatively more associated with EEM adoption. Further, the analysis of marginal effect indicates that enterprise characteristics such as age, size, ownership, lean operations, spending on R&D, availing credit and certification significantly impact the adoption of EEMs. Similarly, firms with higher capacity utilisation and facing business obstacles such as access to resources, regulations and externalities have significantly influenced the adoption of EEMs.

Practical implications
This study provides insights to firms in devising strategies and managing factors affecting the adoption of each element of EEM for enhancing efficiency and encouraging green economy practices.

Originality/value
Considering energy conservation and efficiency as an area of concern among the firms and the availability of limited comprehensive empirical investigation, this study provides unique theoretical and practical contributions.
Striking the balance: unraveling the influence of organizational culture on organization citizenship behavior with corporate social responsibility as the bridge
Authors: Iqbal Junaid , Parray Zahoor Ahmad 
Published: November 2024

PurposeThis comprehensive study, grounded in social identity theory, aimed to explore the intricate dynamics between clan, adhocracy, hierarchy and market cultures within organizations, and their respective impacts on organizational citizenship behavior. Furthermore, the research investigated the mediating role of corporate social responsibility in this relationship.Design/methodology/approachThe study gathered data from 477 bank employees in UT Jammu and Kashmir, utilizing a cluster sampling methodology. SPSS and AMOS were employed to assess the model and hypotheses, thereby strengthening the reliability of the results.FindingsThe findings significantly highlight the influential roles played by clan, adhocracy, hierarchy, and market cultures in shaping organizational citizenship behavior. Moreover, the study underscores the pivotal role of corporate social responsibility as a mediator in the relationship between these organizational culture dimensions and organizational citizenship behavior.Originality/valueThis research enhances the application of social identity theory in organizational settings. It offers valuable insights for managers and supervisors aiming to utilize organizational culture and corporate social responsibility initiatives to improve positive employee behaviors. The practical implications derived from this study provide actionable strategies to optimize workplace dynamics, fostering a culture that promotes organizational citizenship behavior. Ultimately, this contributes to improved organizational performance and employee satisfaction.
Green banking, sustainability and COVID-19: a systematic literature review
Authors: Goswami Anju 
Published: November 2024

PurposeThis study presents a systematic literature review on green banking (GB) and sustainability from 2012 to 2024, filtering 45 out of 561 research publications.Design/methodology/approachUsing NVivo and Biblioshiny, the study employed a combination of bibliometric analysis and thematic analysis, representing a novel approach in this field.FindingsThe analysis of ‘term frequency' results has indicated that the term “green banking” has gained significant attention during the peak of the COVID-19 pandemic, followed by sustainability and green finance. This suggests that approximately 12.5% of the literature on GB has emerged shortly after the first wave of the COVID-19 crisis. Cluster analysis and network analysis has divided the GB articles into two major clusters and one minor cluster. Most studies cover titles such as “sustainable”, “sustainable development” and “sustainability.” However, there is a significant gap in research on the theme of GB. Aside from legitimacy and stakeholder theories, no clear theoretical frameworks have yet been published in the field of GB. Among all categories of publishers, Elsevier ranks highest for publishing journal articles on “green” topics. According to publication output by country, China leads with 17 publications, followed by Malaysia with 11, and both Australia and India with nine each.Practical implicationsThe in-depth research on GB provides fresh insights for policymakers and academics regarding future research directions.Originality/valueThis study is likely the first to incorporate both bibliometric and thematic analysis to explore the growing phenomenon of GB. Furthermore, none of the existing banking literature explicitly addresses the relevant questions and themes that could benefit future researchers and policymakers.
Shadows across cultures: exploring the dark side of anthropomorphized agents
Authors: Husain Rehan , Tripathi Shalini Nath 
Published: November 2024

Purpose
This study aims to delve into the cultural differences between developing and developed countries pertaining to the negative behavioral fallouts of adopting anthropomorphized humanoids or robots. The underlying motivation (for the study) lies in the fact that these countries are at the vanguard of artificial intelligence development and deployment, albeit with varying levels of development and acceptance.

Design/methodology/approach
The research framework used in this study is guided by the computers as social actors framework, expectancy disconfirmation theory and is supported by the uncanny valley theory. The data was collected in two contexts using probabilistic sampling technique, N= = 782 (n1 = 393 respondents: developed country i.e. USA and n2 = 389 respondents: developing country i.e. India). The partial least square analysis was carried out for the proposed model’s validation and hypotheses testing.

Findings
This study shows that in developed countries, the consumers have high preinteraction expectations while they express comparatively more dark behavior than respondents from developing countries. Consumers in developed countries focus on anthropomorphic knowledge and design cues, while in developing countries, they pay attention to utility and functionality. Finally, the results also suggest that female respondents from developed countries exhibit more resilience toward anthropomorphized agents in adopting and expressing dark behavior.

Originality/value
The present research makes essential contributions to anthropomorphism literature. First, this study explored impact of the interaction effect on the dark side, a rather under-explored domain in regret literature. Second, this study provides evidence for cross-cultural variations pertaining to the dark side impacts. Finally, this study adds to impact of demographic variables, showing that gender played a significant role in moderating relationships in the proposed model.
Effects of competitive intelligence and halal integrity on Halalan Tayyiban implementation strategy in Indonesian MSMEs: the mediating role of halal orientation strategy
Authors: Susiang Maria Imelda Novita , Siswanti Indra , Permana Dudi , Wibowo Mas Wahyu 
Published: November 2024

Purpose
Indonesia is a leading producer and consumer of halal products globally. Micro, small and medium enterprises (MSMEs) play a vital role in this market; however, ensuring the integrity and effectiveness of their halal practices remains a concern. This study aims to investigate the interplay among competitive intelligence (CI), halal integrity (HI), halal orientation strategy (HOS) and Halalan Tayyiban implementation strategy (HTIS) within Indonesian MSMEs.

Design/methodology/approach
A total of 250 questionnaires were administered to Indonesian MSMEs, and 210 valid responses were analyzed using SmartPLS.

Findings
The HOS mediates the relationship between CI/HI and HTIS in Indonesian MSMEs by ensuring that CI gathered by MSMEs aligns with HI requirements, leading to successful HTIS. This integrated approach enhances the MSMEs’ market competitiveness and ensures that their products comply with Islamic principles and quality standards.

Research limitations/implications
Future studies could examine the impact of a robust HOS on CI use, how HOS moderates the relationship between HI and resource allocation for HTIS and how HTIS affects performance outcomes.

Practical implications
Indonesian MSMEs should update their strategies based on CI insights and changes in HI requirements. Investigating how these findings translate across diverse regions with significant Muslim populations (Southeast Asia and the Middle East) can provide insights into the influence of cultural variations on the relationships among HOS, CI, HI and HTIS.

Social implications
By emphasizing HI throughout operations, MSMEs build trust and ensure products adhere to ethical and religious principles. The emphasis on maintaining high halal integrity throughout business operations reinforces ethical and religious principles within the halal market. By adhering to strict halal standards and certification processes, businesses uphold the integrity of their products and services, contributing to the preservation of religious values and ethical practices within society.

Originality/value
The findings provide a roadmap for successful strategy formulation and implementation in the halal industry.