bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical Utility of Prospective Molecular Characterization in Advanced Endometrial Cancer
Authors: Soumerai Tara E. , Donoghue Mark T.A. , Bandlamudi Chaitanya , Srinivasan Preethi , Chang Matthew T. , Zamarin Dmitriy , Cadoo Karen A. , Grisham Rachel N. , O'Cearbhaill Roisin E. , Tew William P. , Konner Jason A. , Hensley Martee L. , Makker Vicky , Sabbatini Paul , Spriggs David R. , Troso-Sandoval Tiffany A. , Charen Alexandra Snyder , Friedman Claire , Gorsky Mila , Schweber Sarah J. , Middha Sumit , Murali Rajmohan , Chiang Sarah , Park Kay J. , Soslow Robert A. , Ladanyi Marc , Li Bob T. , Mueller Jennifer , Weigelt Britta , Zehir Ahmet , Berger Michael F. , Abu-Rustum Nadeem R. , Aghajanian Carol , DeLair Deborah F. , Solit David B. , Taylor Barry S. , Hyman David M. 
Published: August 2018

Abstract

Purpose:
Advanced-stage endometrial cancers have limited treatment options and poor prognosis, highlighting the need to understand genetic drivers of therapeutic vulnerabilities and/or prognostic predictors. We examined whether prospective molecular characterization of recurrent and metastatic disease can reveal grade and histology-specific differences, facilitating enrollment onto clinical trials.

Experimental Design:
We integrated prospective clinical sequencing and IHC data with detailed clinical and treatment histories for 197 tumors, profiled by MSK-IMPACT from 189 patients treated at Memorial Sloan Kettering Cancer Center.

Results:
Patients had advanced disease and high-grade histologies, with poor progression-free survival on first-line therapy (PFS1). When matched for histology and grade, the genomic landscape was similar to that of primary untreated disease profiled by TCGA. Using multiple complementary genomic and mutational signature-based methods, we identified patients with microsatellite instability (MSI), even when standard MMR protein IHC staining failed. Tumor and matched normal DNA sequencing identified rare pathogenic germline mutations in BRCA2 and MLH1. Clustering the pattern of DNA copy-number alterations revealed a novel subset characterized by heterozygous losses across the genome and significantly worse outcomes compared with other clusters (median PFS1 9.6 months vs. 17.0 and 17.4 months; P = 0.006). Of the 68% of patients harboring potentially actionable mutations, 27% were enrolled to matched clinical trials, of which 47% of these achieved clinical benefit.

Conclusions:
Prospective clinical sequencing of advanced endometrial cancer can help refine prognosis and aid treatment decision making by simultaneously detecting microsatellite status, germline predisposition syndromes, and potentially actionable mutations. A small overall proportion of all patients tested received investigational, genomically matched therapy as part of clinical trials.
‘Returning to our Spiritual Roots’: African Hindus in Ghana Negotiating Religious Space and Identity
Authors: Ofori Atiemo Abamfo 
Published: August 2018

AbstractThis paper examines the phenomenon of the ‘African Hindu’ in the context of the discussions on ‘transnational Hinduism’. I also report on how these African Hindus resort to a reinterpretation of the history of their Ghanaian indigenous (traditional) religion and culture in their attempt to find religious space in the almost-choked religious environment of Ghana, and also how they attempt to negotiate their new religious identity in relation to their identity as Africans (Ghanaians). I conclude with a prognosis of the form that Hinduism is likely to assume in the near future on Ghanaian soil as its African converts try to live their faith in the context of their local culture.
Getting More out of Storm Surge Forecasts: Emergency Support Personnel Needs in North Carolina
Authors: Munroe Robert , Montz Burrell , Curtis Scott 
Published: August 2018

Abstract
Storm surge has been identified as a dangerous and damaging coastal hazard that is expected to be exacerbated by rising sea levels. However, storm surge research and applications are relatively new and poorly understood compared to other storm-related hazards. This survey-based research of emergency support personnel across eastern North Carolina aims to connect ongoing research with the needs of storm surge users. Results indicate that emergency managers and other emergency support functions depend on storm surge information to assess and communicate risk, to educate the public, to evacuate the public, or for long-term resilience and recovery planning. They were generally satisfied with the type and timing of currently available surge information, but desired additional types of surge information (i.e., timing) and longer lead times.
Effects of geriatric interdisciplinary home rehabilitation on complications and readmissions after hip fracture: a randomized controlled trial
Authors: Berggren Monica , Karlsson Åsa , Lindelöf Nina , Englund Undis , Olofsson Birgitta , Nordström Peter , Gustafson Yngve , Stenvall Michael 
Published: August 2018

Objective: This pre-planned secondary analysis of geriatric interdisciplinary home rehabilitation, which was initially found to shorten the postoperative length of stay in hospital for older individuals following hip fracture, investigated whether such rehabilitation reduced the numbers of complications, readmissions, and total days spent in hospital after discharge during a 12-month follow-up period compared with conventional geriatric care and rehabilitation. Design: Randomized controlled trial. Setting: Geriatric department, participants’ residential care facilities, and ordinary housing. Subjects: Individuals aged ⩾70 years with acute hip fracture ( n = 205) were included. Intervention: Geriatric interdisciplinary home rehabilitation was individually designed and aimed at early discharge with the intention to prevent, detect, and treat complications after discharge. Main measures: Complications, readmissions, and days spent in hospital were registered from patients’ digital records and interviews conducted during hospitalization and at 3- and 12-month follow-up visits. Results: No significant difference in outcomes was observed. Between discharge and the 12-month follow-up, among participants in the geriatric interdisciplinary home rehabilitation group ( n = 106) and control group ( n = 93), 57 (53.8%) and 44 (47.3%) had complications ( P = 0.443), 46 (43.4%) and 38 (40.9%) fell ( P = 0.828), and 38 (35.8%) and 27 (29.0%) were readmitted to hospital ( P = 0.383); the median total days spent in hospital were 11.5 and 11.0 ( P = 0.353), respectively. Conclusion: Geriatric interdisciplinary home rehabilitation for older individuals following hip fracture resulted in similar proportions of complications, readmissions, and total days spent in hospital after discharge compared with conventional geriatric care and rehabilitation.
Effect of adding neuromuscular electrical stimulation training to pulmonary rehabilitation in patients with chronic obstructive pulmonary disease: randomized clinical trial
Authors: Mekki Marwa , Paillard Thierry , Sahli Sonia , Tabka Zouhair , Trabelsi Yassine 
Published: August 2018

Objective: To investigate the effectiveness of neuromuscular electrical stimulation added to pulmonary rehabilitation on walking tolerance and balance in patients with chronic obstructive pulmonary disease (COPD). Design: Randomized clinical trial. Setting: Outpatient, Faculty of Medicine of Sousse, Tunisia. Subjects: A total of 45 patients with COPD were assigned to an intervention group ( n = 25) or a control group ( n = 20). Interventions: The intervention group underwent a neuromuscular electrical stimulation added to pulmonary rehabilitation, and the control group underwent only a pulmonary rehabilitation, three times per week during six months. Main Measures: Measures were taken at baseline and after six months of training. A stabilometric platform, time up and go, Berg balance scale tests, 6 minute walking test, and the maximal voluntary contraction were measured. Results: In the intervention group, an increase in an exercise tolerance manifested by a longer distance walked in 6 minute walking test 619.5 (39.6) m was observed in comparison to the control group 576.3 (31.5) m. The values of the time up and go, Berg balance scale, and maximal voluntary contraction in the intervention group at follow-up were significantly higher than those in the control group ( P  = 0.02, P  = 0.01, P  = 0.0002, respectively). The center of pressure in the mediolateral and in the anteroposterior directions, as well as the center of pressure area was significantly more improved in open eyes and closed eyes in the intervention group compared to the control group ( P < 0.001). Conclusion: The neuromuscular electrical stimulation added to pulmonary rehabilitation group benefited from better walking tolerance and greater balance improvement than the only pulmonary rehabilitation.
Marine geological researches in the greater bay of Navarino area, Southern Ionian sea
Authors: ΠΕΡΙΣΟΡΑΤΗΣ Κ. , ΚΟΝΙΣΠΟΛΙΑΤΗΣ Ν. , ΖΗΜΙΑΝΙΤΗΣ Ε. , ΓΑΛΑΝΟΠΟΥΛΟΥ Σ. , ΖΑΧΑΡΑΚΗ Π. 
Published: August 2018

This paper examines the marine area of the Bay of Navarino and the Ionian sea sector to the west of the bay, based on a collection of shallow and intermediate penetration seismic profiles and on three gravity cores. The Bay has a smooth sea bottom morphology with maximum depth (75m) toward the south. Two minor reefs penetrate the sea bottom, one of them rising above the sea level forming a rocky island. In the open sea area the sea bottom is anomalous, especially after the shelf break, that is distinguished at a depth of approx. 160m. Beyond this depth deep valleys and ridges alternate and produce a rough morphology. The examination of the three gravity cores indicated that their sediment sand composition is mainly biogenic with minor amounts of terrigenous material. Increased shell fragments and terrigenous material was found at the bottom of one core taken at a depth of 116m, related probably to wave action at an earlier sea level position. The study of the seismic profiles collected within the bay and in the shelf area revealed,the presence of two distinct sedimentation units, un upper A filling with loose sediments the basins that are formed in the lower Y which is the basement. Within unit A two distinct subunits are recognized Al and A2, separated by an unconformity. In the sector to the west of the bay and beyond the shelf break, alternating opaque and transparent sediment packages are present, that are attributed to earlier sedimentation phases of low/high sea level stages. An older shelf break feature correlated with sea level stage 6 was distinguished at approx. 250m. sea depth. Thus subsidence rate in the area is estimated between 1 and 2 mm/year. The comparison of all data with the known sea level change curve indicated that unit AI was deposited during and after the latest transgression (stage 1) the unconformity between Al and A2 is related to the previous regression (stage 2), while the deposition of the unit A2 took place probably during stages 3 and/or 5. The morphology of the basement Y in the bay and the shelf area is thus attributed probably to stage 6 when the area was again subaerially exposed.
Collaboration between a human group and artificial intelligence can improve prediction of multiple sclerosis course: a proof-of-principle study
Authors: Tacchella Andrea , Romano Silvia , Ferraldeschi Michela , Salvetti Marco , Zaccaria Andrea , Crisanti Andrea , Grassi Francesca 
Published: August 2018

Background:Multiple sclerosis has an extremely variable natural course. In most patients, disease starts with a relapsing-remitting (RR) phase, which proceeds to a secondary progressive (SP) form. The duration of the RR phase is hard to predict, and to date predictions on the rate of disease progression remain suboptimal. This limits the opportunity to tailor therapy on an individual patient's prognosis, in spite of the choice of several therapeutic options.Approaches to improve clinical decisions, such as collective intelligence of human groups and machine learning algorithms are widely investigated.Methods:Medical students and a machine learning algorithm predicted the course of disease on the basis of randomly chosen clinical records of patients that attended at the Multiple Sclerosis service of Sant'Andrea hospital in Rome.Results:A significant improvement of predictive ability was obtained when predictions were combined with a weight that depends on the consistence of human (or algorithm) forecasts on a given clinical record.Conclusions:In this work we present proof-of-principle that human-machine hybrid predictions yield better prognoses than machine learning algorithms or groups of humans alone. To strengthen and generalize this preliminary result, we propose a crowdsourcing initiative to collect prognoses by physicians on an expanded set of patients.
A retrospective study on atrial fibrillation after coronary artery bypass grafting surgery at The National Heart Institute, Kuala Lumpur
Authors: Farouk Musa Ahmad , Quan Chou Zhao , Xin Low Zheng , Soni Trived , Dillon Jeswant , Hay Yuen Kah , Nordin Rusli Bin 
Published: August 2018

Background: Atrial fibrillation (AF) is common after cardiac surgery and has been associated with poor outcome and increased resource utilization. The main objective of this study is to determine the incidence of POAF in Malaysia and identify the predictors of developing POAF. The secondary outcome of this study would be to investigate the difference in mortality and morbidity rates and the duration of intensive care unit (ICU), high dependency unit (HDU) and hospital stay between the two. Methods: This is a retrospective single-center, cross sectional study conducted at the National Heart Institute, Malaysia. Medical records of 637 who underwent coronary artery bypass grafting (CABG) surgery in 2015 were accrued. Pre-operative, operative and post-operative information were subsequently collected on a pre-formulated data collection sheet. Data were then analyzed using IBM SPSS v23. Results: The incidence of POAF in our study stands at 28.7% with a mean onset of 45±33 hours post operatively. Variables with independent association with POAF include advancing age, Indian population, history of chronic kidney disease, left ventricular ejection fraction and beta-blocker treatment. The mortality rate is significantly higher statistically (p < 0.05), and similarly the incidence of stroke. The incidence of other post-operative complications was also significantly higher statistically. The duration of ICU, HDU and hospital stays were statistically longer (p < 0.001) with higher rates of ICU readmissions and reintubations seen. Conclusion: We conclude that the incidence of POAF in Malaysia is comparable to the figures in Western countries, making POAF one of the most commonly encountered condition after CABG with similar higher rates of mortality, poor outcomes and longer duration of stay, and therefore increased cost of care. Strategies to reduce the incidence of AF after cardiac surgery should favorably affect surgical outcomes and reduce utilization of resources and thus lower cost of care.
Scaled deployment of Wolbachia to protect the community from Aedes transmitted arboviruses
Authors: O'Neill Scott L. , Ryan Peter A. , Turley Andrew P. , Wilson Geoff , Retzki Kate , Iturbe-Ormaetxe Inaki , Dong Yi , Kenny Nichola , Paton Christopher J. , Ritchie Scott A. , Brown-Kenyon Jack , Stanford Darren , Wittmeier Natalie , Anders Katherine L. , Simmons Cameron P. 
Published: August 2018

Background: A number of new technologies are under development for the control of mosquito transmitted viruses, such as dengue, chikungunya and Zika that all require the release of modified mosquitoes into the environment. None of these technologies has been able to demonstrate evidence that they can be implemented at a scale beyond small pilots. Here we report the first successful citywide scaled deployment of Wolbachia in the northern Australian city of Townsville. Methods: The wMel strain of Wolbachia was backcrossed into a local Aedes aegypti genotype and mass reared mosquitoes were deployed as eggs using mosquito release containers (MRCs). In initial stages these releases were undertaken by program staff but in later stages this was replaced by direct community release including the development of a school program that saw children undertake releases. Mosquito monitoring was undertaken with Biogents Sentinel (BGS) traps and individual mosquitoes were screened for the presence of Wolbachia with a Taqman qPCR assay. Dengue case notifications from Queensland Health Communicable Disease Branch were used to track dengue cases in the city before and after release. Results: Wolbachia was successfully established into local Ae. aegypti mosquitoes across 66 km2 in four stages over 28 months with full community support. A feature of the program was the development of a scaled approach to community engagement. Wolbachia frequencies have remained stable since deployment and to date no local dengue transmission has been confirmed in any area of Townsville after Wolbachia has established, despite local transmission events every year for the prior 13 years and an epidemiological context of increasing imported cases. Conclusion: Deployment of Wolbachia into Ae. aegypti populations can be readily scaled to areas of ~60km2 quickly and cost effectively and appears in this context to be effective at stopping local dengue transmission
Molecular characterization and morphological description of cryptic haemoproteids in the laughingthrushes (Leiothrichidae) in the western and eastern Himalaya, India
Authors: Ishtiaq Farah , Rao Megha , Palinauskas Vaidas 
Published: August 2018

Background: Laughingthrushes (family: Leiothrichidae) consists of diverse and widespread species found in the Indian subcontinent but there is a lack of information on their avian haemosporidians. Methods: We sampled 231 laughingthrushes of 8 species in the western and eastern Himalaya in India. Using parasite morphology and cytochrome b sequences we describe 2 new Haemoproteus species harbored in 3 species of laughingthrushes and report a case of cryptic speciation. Results: First Haemoproteus lineage TROERY01 (GenBank: KY623720) found in Trochalopteron erythrocephalum (27.47%) and Trochalopteron variegatum (2.9%) in mid to high altitude tropical forests in the western and eastern Himalaya, was described as Haemoproteus (Parahaemoproteus) leiothrichus n. sp. (Haemosporida: Haemoproteidae). Second Haemoproteus lineage TROERY02 (GenBank: KY623721) described as Haemoproteus (Parahaemoproteus) homoleiothrichus n. sp. (Haemosporida: Haemoproteidae) was found in T. erythrocephalum (2.19%) and Trochalopteron lineatum (3.84%), albeit in low intensity, only in the western Himalaya. Both H. homoleiothrichus n. sp. and H. leiothrichus n. sp. showed no significant difference in morphological features in blood stages. A genetic divergence of 4.4% along with distinct phylogenetic position indicates that these 2 lineages represent cryptic species. Previously, T. erythrocephalum has been described as an additional host for a morphologically described Haemoproteus timalus in the oriental region. Our described species have several morphological features that are absent in H. timalus. These are, the presence of dumbbell-like shaped mature gametocytes, ‘arm’ like extensions of gametocytes and lateral displacement of nuclei of infected erythrocytes. Illustrations of blood stages of the new species are given, and phylogenetic analysis with morphologically described Haemoproteus species identifies parasites closely related to the 2 described parasites. Conclusions: The lineages described here have been recorded only in the laughingthrushes so far. These are the first parasites to be described with T. erythrocephalum as a type host from the western and eastern Himalaya in India.
Diagnostic Thresholds for Androgen-Producing Tumors or Pathologic Hyperandrogenism in Women by Use of Total Testosterone Concentrations Measured by Liquid Chromatography-Tandem Mass Spectrometry
Authors: Sharma Anu , Kapoor Ekta , Singh Ravinder J , Chang Alice Y , Erickson Dana 
Published: August 2018

Abstract

BACKGROUND
Previously defined thresholds for total testosterone (TT) concentrations to screen for androgen-producing tumors (APTs) have used RIA, which can be less accurate in women. We aimed to define diagnostic thresholds to screen for APTs or postmenopausal pathologic hyperandrogenism using TT concentrations measured by Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS).

METHODS
We performed a retrospective cohort study on all women with TT ≥3.5 nmol/L and all postmenopausal women presenting with hyperandrogenism between 2004 and 2014 at the Mayo Clinic in Rochester, MN.

RESULTS
Of the 369 women with TT ≥3.5 nmol/L, 89 were included and subdivided into 3 groups based on their clinical diagnosis [21 (24%), APT; 16 (18%), postmenopausal pathologic hyperandrogenism; 52 (58%), polycystic ovary syndrome]. The source of the APT was more frequently ovarian (81%, n = 17) than adrenal (19%, n = 4). The diagnostic threshold using ROC analysis for TT to identify APT in women with severe biochemical hyperandrogenemia was ≥5.1 nmol/L (sensitivity, 90%; specificity, 81%). In a second analysis of a cohort of postmenopausal women only presenting with symptoms or signs of hyperandrogenism, median TT was significantly higher in the postmenopausal pathologic hyperandrogenism group (APT and ovarian hyperthecosis) vs the idiopathic hyperandrogenism group (4.9 vs 0.8 nmol/L; P &lt; 0.01). In postmenopausal women, the diagnostic threshold for pathologic hyperandrogenism was TT ≥2.2 nmol/L (sensitivity, 100%; specificity, 86%).

CONCLUSIONS
The diagnostic threshold for TT concentration as measured by LC-MS/MS to identify APT in women with biochemical severe hyperandrogenemia was TT ≥5.1 nmol/L. In postmenopausal women, the diagnostic threshold for pathologic hyperandrogenism was lower (TT ≥2.2 nmol/L).
Sensitivitas dan spesifisitas food consumption score dalam mengidentifikasi rawan pangan dengan parameter status gizi balita
Authors: Firna Aklesta Leni , Bambang Azis Nur , Afifah Diana Nur 
Published: August 2018

Background : Food consumption score (FCS) was one of indicators to measure the food insecurity that included some elements from food access and food consumption, but the sensitivity was different in each area so it was needed to do the sensitivity and specificity tests with the high precision and accuracy of parameter. Objectives : To do the sensitivity and specificity test of food consumption score to identify the food insecurity with parameter status of toddlers’ nutrition anthropometrically. Methods : Cross sectional study with total subjects 517 toddlers. Status of toddlers’ nutrition was counted according to zscore WHZ, WAZ, and HAZ. The FCS score was counted according to WFP formula. Results : Sensitivity (Se) and specificity (Sp) FCS test with parameter of WHZ, WAZ, HAZ as followed Se=0 Sp= ≥ 90%. Conclusion: The cut-off point of FCS that was set by WFP was non-sensitive in identifying the food insecurity with parameter status of toddlers’ nutrition.