bluuebunny/crossref_metadata_2025_split huggingface dataset:
An ADAR1 inducer attenuated the effects of social isolation on depressive-like behavior and ADAR1 (p110) in BALB/c mice
Authors: Xue Ying , Yu Weizhi , Li Jinying , Hong Xu , Zhang Xiaonan , Li Huairui , Zhai Xiuli , Gao Ye , Gui Lin , Yu Deqin , Xiao Zhaoyang , Tang Yiyuan , Yin Shengming 
Published: December 2018

Introduction
Social isolation induces depressive-like behavior in animals and humans by impacting RNA editing, but the detailed mechanisms are still unknown. The purpose of this study was to explore how an ADAR1 (RNA-editing enzyme) inducer and inhibitor may impact the isolation-induced depressive-like behavior of mice and to identify new therapeutic targets for the development of an effective solution for the recovery from depressive-like behavior in socially isolated animals and humans.
Methods
Twenty-one-day-old BALB/c mice with and without isolation treatment were evaluated for depressive-like behavior by open-field tests, tail suspension tests, and forced swimming tests. Immunohistochemistry and Western blots were used to measure the immunoreactivity and protein expression of ADAR1 (p110). In addition, the isolated mice were treated with an ADAR1 inducer (IFN-γ) or inhibitor (EHNA). The performance of both treatments on the behavior of and ADAR1 (p110) expression in isolated mice was examined.
Results
Both the immunoreactivity and protein expression of ADAR1 (p110) in the prefrontal cortex decreased in isolated BALB/c mice with depressive-like behavior compared to those of the age-matched, gregarious BALB/c mice. Additionally, the treatments with ADAR1 inducer or inhibitor improved or aggravated depressive-like behavior in isolated mice, respectively. Furthermore, the ADAR1 inducer returned the immunoreactivity and protein expression of ADAR1 (p110) back to the normal level.
Conclusion
The ADAR1 inducer attenuated the effects of social isolation on depressive-like behavior and ADAR1 (p110) in BALB/c mice.
The Influence of Physicochemical Properties of Biomimetic Hydroxyapatite on the In Vitro Behavior of Endothelial Progenitor Cells and Their Interaction with Mesenchymal Stem Cells
Authors: Sadowska Joanna Maria , Guillem‐Marti Jordi , Ginebra Maria‐Pau 
Published: December 2018

AbstractCalcium phosphate (CaP) substrates are successfully used as bone grafts due to their osteogenic properties. However, the influence of the physicochemical features of CaPs in angiogenesis is frequently neglected despite it being a crucial process for bone regeneration. The present work focuses on analyzing the effects of textural parameters of biomimetic calcium deficient hydroxyapatite (CDHA) and sintered beta‐tricalcium phosphate (β‐TCP), such as specific surface area, surface roughness, and microstructure, on the behavior of rat endothelial progenitor cells (rEPCs) and their crosstalk with rat mesenchymal stem cells (rMSCs). The higher reactivity of CDHA results in low proliferation rates in monocultured and cocultured systems. This effect is especially pronounced for rMSCs alone, and for CDHA with a fine microstructure. In terms of angiogenic and osteogenic gene expressions, the upregulation of particular genes is especially enhanced for needle‐like CDHA compared to plate‐like CDHA and β‐TCP, suggesting the importance not only of the chemistry of the substrate, but also of its textural features. Moreover, the coculture of rEPCs and rMSCs on needle‐like CDHA results in early upregulation of osteogenic modulator, i.e., protein deglycase 1 might be a possible cause of overexpression of osteogenic‐related genes on the same substrate.
Fungi‐Enabled Synthesis of Ultrahigh‐Surface‐Area Porous Carbon
Authors: Wang Ping , Ye Huan , Yin Ya‐Xia , Chen Hao , Bian Yin‐Bing , Wang Zhuo‐Ren , Cao Fei‐Fei , Guo Yu‐Guo 
Published: December 2018

AbstractThe growth of white‐rot fungi is related to the superior infiltrability and biodegradability of hyphae on a lignocellulosic substrate. The superior biodegradability of fungi toward plant substrates affords tailored microstructures, which benefits subsequently high efficient carbonization and chemical activation. Here, the mechanism underlying the direct growth of mushrooms toward the lignocellulosic substrate is elucidated and a fungi‐enabled method for the preparation of porous carbons with ultrahigh specific surface area (3439 m2 g−1) is developed. Such porous carbons could have potential applications in energy storage, environment treatment, and electrocatalysis. The present study reveals a novel pore formation mechanism in root‐colonizing fungi and anticipates a valuable function for fungi in developing the useful porous carbons with a high specific surface area.
N‐Doped C@Zn3B2O6 as a Low Cost and Environmentally Friendly Anode Material for Na‐Ion Batteries: High Performance and New Reaction Mechanism
Authors: Wang Sai , Zhang Xin‐Bo 
Published: December 2018

AbstractNa‐ion batteries (NIBs) are ideal candidates for solving the problem of large‐scale energy storage, due to the worldwide sodium resource, but the efforts in exploring and synthesizing low‐cost and eco‐friendly anode materials with convenient technologies and low‐cost raw materials are still insufficient. Herein, with the assistance of a simple calcination method and common raw materials, the environmentally friendly and nontoxic N‐doped C@Zn3B2O6 composite is directly synthesized and proved to be a potential anode material for NIBs. The composite demonstrates a high reversible charge capacity of 446.2 mAh g−1 and a safe and suitable average voltage of 0.69 V, together with application potential in full cells (discharge capacity of 98.4 mAh g−1 and long cycle performance of 300 cycles at 1000 mA g−1). In addition, the sodium‐ion storage mechanism of N‐doped C@Zn3B2O6 is subsequently studied through air‐insulated ex situ characterizations of X‐ray diffraction (XRD), X‐ray photoelectron spectroscopy (XPS), and Fourier‐transform infrared (FT‐IR) spectroscopy, and is found to be rather different from previous reports on borate anode materials for NIBs and lithium‐ion batteries. The reaction mechanism is deduced and proposed as: Zn3B2O6 + 6Na+ + 6e− ⇋ 3Zn + B2O3 ∙ 3Na2O, which indicates that the generated boracic phase is electrochemically active and participates in the later discharge/charge progress.
Double‐Layer Polymer Electrolyte for High‐Voltage All‐Solid‐State Rechargeable Batteries
Authors: Zhou Weidong , Wang Zhaoxu , Pu Yuan , Li Yutao , Xin Sen , Li Xiaofang , Chen Jianfeng , Goodenough John B. 
Published: December 2018

AbstractNo single polymer or liquid electrolyte has a large enough energy gap between the empty and occupied electronic states for both dendrite‐free plating of a lithium‐metal anode and a Li+ extraction from an oxide host cathode without electrolyte oxidation in a high‐voltage cell during the charge process. Therefore, a double‐layer polymer electrolyte is investigated, in which one polymer provides dendrite‐free plating of a Li‐metal anode and the other allows a Li+ extraction from an oxide host cathode without oxidation of the electrolyte in a 4 V cell over a stable charge/discharge cycling at 65 °C; a poly(ethylene oxide) polymer contacts the lithium‐metal anode and a poly(N‐methyl‐malonic amide) contacts the cathode. All interfaces of the flexible, plastic electrolyte remain stable with no visible reduction of the Li+ conductivity on crossing the polymer/polymer interface.
A 1D Magnetoelectric Sensor Array for Magnetic Sketching
Authors: Chu Zhaoqiang , Shi Weiliang , Shi Huaduo , Chen Qingxiao , Wang Lei , PourhosseiniAsl Mohammad Javad , Xiao Chijie , Xie Tianyu , Dong Shuxiang 
Published: December 2018

AbstractAlthough various magnetic sensors have been developed, tiny magnetic object detection is still a challenging issue in some cases, such as capsule position detection, endoscope navigation, and the detection of magnetic devices hidden in/on the human body. In this paper, a magnetic detecting and sketching system utilizing a 1D magnetic sensor array with 56 magnetoelectric (ME) sensing units is proposed. The ME sensors used in this system are based on a (1‐1) connectivity Metglas/piezofiber composite operating in the longitudinally magnetized and transversely poled (L‐T) mode. Simulation and experiment results show that the proposed magnetic detecting system can not only monitor the 2D position of a running magnetic metal object, but it can also identify its posture and length‐diameter ratio. The proposed magnetic detecting method is, therefore, very promising for medical magnetic positioning and security checking.
Butterfly‐Inspired Triboelectric Nanogenerators with Spring‐Assisted Linkage Structure for Water Wave Energy Harvesting
Authors: Lei Rui , Zhai Hua , Nie Jinhui , Zhong Wei , Bai Yu , Liang Xi , Xu Liang , Jiang Tao , Chen Xiangyu , Wang Zhong Lin 
Published: December 2018

AbstractThe exploration of water wave energy to generate electric power is a promising and valuable way to solve global energy crisis. Triboelectric nanogenerators (TENGs) are considered as one of the most promising approaches for harvesting water wave energy. Here, a butterfly‐inspired triboelectric nanogenerator (B‐TENG) with spring‐assisted four‐bar linkage is fabricated to acquire multidirectional water wave energy from different types of movements generated by the device. The arc‐shaped outer shell can efficiently absorb the impact force of water wave and inner spring‐assisted four‐bar linkage can induce multiple contact–separation motion of TENG module, both of which allow the B‐TENG to harvest energy from different types of low‐frequency waves. The short‐circuit current and open‐circuit voltage of this B‐TENG device can reach 75.35 µA and 707.01 V, while a maximum output power density of 9.559 W m−3 can be achieved and 180 light‐emitting diodes can be directly lightened up by this B‐TENG. The energy generated from this B‐TENG can also be stored in a capacitor and to drive some marine sensor devices, such as an electronic thermometer. This proposed B‐TENG device is specially designed for multidirectional water energy harvesting and it may have good application prospects for ocean information monitoring and power supply to oceanic islands.
Bladeless‐Turbine‐Based Triboelectric Nanogenerator for Fluid Energy Harvesting and Self‐Powered Fluid Gauge
Authors: Chen Jian , Tang Wei , Han Kai , Xu Liang , Chen Baodong , Jiang Tao , Wang Zhong Lin 
Published: December 2018

AbstractTriboelectric nanogenerator (TENG) is attractive as an energy harvesting and self‐powered sensing technology. The working frequency and surface charge density are the key factors that influence the output performance. To boosting the output of the TENG by improving the working frequency, a bladeless turbine–based triboelectric nanogenerator (BT‐TENG) is designed, which transforms the fluid flow into a high rotation motion that drives the rotation TENG. When blown by compressed air, the BT‐TENG rotates at an average speed of 7500 rpm. Owing to its high‐frequency rotation, the short‐circuit current of the BT‐TENG is 60 µA and the output power is 3.6 mW. By integrating six layers of TENG into the bladeless turbine (BT‐6TENGs), the total short‐circuit current is 180 µA and the output power reaches 15 mW. The BT‐6TENGs could charge a 4.7 mF capacitor to 3.6 V within 3 min, and continuously drive a wireless sensor to collect data and transmit to a smartphone. In practical applications, the BT‐TENG could harvest steam mechanical energy, which can be widely used in home heat steam to industrial wasted heat. Additionally, the BT‐TENG is integrated within a fluidic system as a self‐powered flow rate sensor.
Portable Multiplex Optical Assays
Authors: Coskun Ahmet F. , Topkaya Seda Nur , Yetisen Ali K. , Cetin Arif E. 
Published: December 2018

AbstractGlobal health issues are increasingly becoming critical with high fatality rate due to chronic and infectious diseases. Emerging technologies aim to address these problems by understanding the causes of lethal conditions and diagnosing symptoms at early stage. Existing commercial diagnostics primarily focus on single‐plex assays due to ease‐of‐use, simplicity in analysis, and amenability to mass manufacturing. Many research grade devices have utilized only a few molecular and morphological signatures in bodily fluids. However, multiplex devices can improve accuracy, sensitivity, and scalability of research and diagnostic devices. This review presents multiplex assays that utilize optical, electrical, and chemical methods and materials that have the potential to improve portable point‐of‐care diagnostics. The critical role of emerging optical and complementary assays with multiple contrast mechanisms is investigated to enable highly multiplex analysis in field settings. Multiparameter portable devices for field applications toward health monitoring, food testing, air quality monitoring, and microanalysis in other extreme conditions are examined. Current trends indicate the need for validation of health diagnosis based on a large number of biomarkers in randomized clinical trials. Advanced digital analysis, crowd‐sourced solutions, and robust user interfaces will become an integral part of the connected global health systems and personalized monitoring platforms.
Scalable, Highly Uniform, and Robust Colloidal Mie Resonators for All‐Dielectric Soft Meta‐Optics
Authors: Cho YongDeok , Huh Ji‐Hyeok , Kim Kwangjin , Lee Seungwoo 
Published: December 2018

AbstractAll‐dielectric nanoparticles (NPs) with high (>3.0) or moderate (1.7–3.0) refractive indices have become fundamental to meta‐optics, as they enable low‐loss, low‐heating, and quenching‐free magnetodielectric Mie resonances, which are difficult to achieve by use of plasmonic counterparts. However, a scalable and versatile synthetic route for such magnetodielectric NPs retaining high uniformity, roundness, and robustness has remained elusive. Thus, soft self‐assembly still represents an underutilized method in the optical engineer's toolset, which in turn limits the accessible range of meta‐optics. Herein, a gram‐scale and versatile synthesis of dielectric colloidal Mie resonators is presented, in which selenous acid precursors are converted into highly uniform, crystalline colloids by a low demand reaction. These crystalline selenium (c‐Se) colloids enable strong electric and magnetic resonances due to their moderate refractive index (2.8–3.2 at optical frequencies), while simultaneously satisfying the requirements of high uniformity, roundness, and robustness. Even with these exotic properties, c‐Se colloids are successfully self‐assembled into various all‐dielectric meta‐optics systems including (i) metafluids exhibiting directional scattering, (ii) metamolecules with nanogap‐dielectric resonances, and (iii) metacrystals with magnetodielectric bandgaps. The design space of all‐dielectric meta‐optics will be greatly expanded by utilizing soft self‐assembly of c‐Se colloids.
Phototunable Morpho Butterfly Microstructures Modified by Liquid Crystal Polymers
Authors: Qing Xin , Liu Yuyun , Wei Jia , Zheng Ran , Zhu Chongyu , Yu Yanlei 
Published: December 2018

AbstractThe unique hierarchical microstructures of the Morpho butterfly wing (MBW) exhibit angle independent blue iridescence. Biomimicking these microstructures and turning them into functional photonic crystals (PhCs) have fascinated scientists yet remain challenging. Here, a phototunable PhC is fabricated by depositing the azobenzene‐containing linear liquid crystal polymer (LLCP) onto the MBW template. Thanks to the excellent mechanical properties and deformability of LLCP, the generated 3D bilayer microstructures demonstrate hierarchical deformation upon UV light irradiation, leading to a blueshift of the reflection peak (70 nm) and a remarkable change of reflectance (40%). This phototunable PhC may have potential applications in pigments, cosmetics, and sensors.
Enantio‐ and Diastereoselective Synthesis of β‐Aryl‐β‐pyrazolyl α‐Amino Acid Esters via Copper‐Catalyzed Reaction of Azomethine Ylides with Benzylidenepyrazolones
Authors: Gong Yan‐Chuan , Wang Yue , Li Er‐Qing , Cui Hao , Duan Zheng 
Published: December 2018

AbstractA fully stereoselective synthesis of unnatural chiral β‐aryl‐β‐pyrazolyl α‐amino acid esters via copper‐catalyzed addition reactions of azomethine ylides with benzylidenepyrazolones bearing two contiguous stereogenic centers was developed. A 1H‐pyrazol‐5‐ol was introduced by the aromatization of 3H‐pyrazol‐3‐one in the reaction. The transformation operated at room temperature and afforded β‐1H‐pyrazol‐5‐ol‐α‐amino esters in high yields with good to excellent levels of diastereo‐ and enantioselectivity.magnified image
Peptide–siRNA Supramolecular Particles for Neural Cell Transfection
Authors: Hernandez‐Garcia Armando , Álvarez Zaida , Simkin Dina , Madhan Ashwin , Pariset Eloise , Tantakitti Faifan , de J. Vargas‐Dorantes Oscar , Lee Sungsoo S. , Kiskinis Evangelos , Stupp Samuel I. 
Published: December 2018

AbstractSmall interfering ribonucleic acid (siRNA)‐based gene knockdown is an effective tool for gene screening and therapeutics. However, the use of nonviral methods has remained an enormous challenge in neural cells. A strategy is reported to design artificial noncationic modular peptides with amplified affinity for siRNA via supramolecular assembly that shows efficient protein knockdown in neural cells. By solid phase synthesis, a sequence that binds specifically double‐stranded ribonucleic acid (dsRNA) with a self‐assembling peptide for particle formation is integrated. These supramolecular particles can be further functionalized with bioactive sequences without affecting their biophysical properties. The peptide carrier is found to silence efficiently up to 83% of protein expression in primary astroglial and neuronal cell cultures without cytotoxicity. In the case of neurons, a reduction in electrical activity is observed once the presynaptic protein synaptophysin is downregulated by the siRNA–peptide particles. The results demonstrate that the supramolecular particles offer an siRNA delivery platform for efficient nonviral gene screening and discovery of novel therapies for neural cells.
Synergistic Effect of 3D Current Collectors and ALD Surface Modification for High Coulombic Efficiency Lithium Metal Anodes
Authors: Chen Kuan‐Hung , Sanchez Adrian J. , Kazyak Eric , Davis Andrew L. , Dasgupta Neil P. 
Published: December 2018

AbstractImproving the performance of Li metal anodes is a critical bottleneck to enable next‐generation battery systems beyond Li‐ion. However, stability issues originating from undesirable electrode/electrolyte interactions and Li dendrite formation have impaired long‐term cycling of Li metal anodes. Herein, a bottom‐up fabrication process is demonstrated for a current collector for Li metal electrodeposition and dissolution composed of highly uniform vertically aligned Cu pillars. By rationally controlling geometric parameters of the 3D current collector architecture, including pillar diameter, spacing, and length, the morphology of Li plating/stripping upon cycling can be controlled and optimal cycling performance can be achieved. In addition, it is demonstrated that deposition of an ultrathin layer of ZnO by atomic layer deposition on the current collector surface can facilitate the initial Li nucleation, which dictates the morphology and reversibility of subsequent cycling. This core–shell pillar architecture allows for the effects of geometry and surface chemistry to be decoupled and individually controlled to optimize the electrode performance in a synergistic manner. Using this platform, Li metal anodes are demonstrated with Coulombic efficiency up to 99.5%, providing a pathway toward high‐efficiency and long‐cycle life Li metal batteries with reduced excess Li loading.
Native Vacancy Enhanced Oxygen Redox Reversibility and Structural Robustness
Authors: Li Yejing , Wang Xuefeng , Gao Yurui , Zhang Qinghua , Tan Guoqiang , Kong Qingyu , Bak Seongmin , Lu Gang , Yang Xiao‐Qing , Gu Lin , Lu Jun , Amine Khalil , Wang Zhaoxiang , Chen Liquan 
Published: December 2018

AbstractCathode materials with high energy density, long cycle life, and low cost are of top priority for energy storage systems. The Li‐rich transition metal (TM) oxides achieve high specific capacities by redox reactions of both the TM and oxygen ions. However, the poor reversible redox reaction of the anions results in severe fading of the cycling performance. Herein, the vacancy‐containing Na4/7[Mn6/7(◻Mn)1/7]O2 (◻Mn for vacancies in the MnO slab) is presented as a novel cathode material for Na‐ion batteries. The presence of native vacancies endows this material with attractive properties including high structural flexibility and stability upon Na‐ion extraction and insertion and high reversibility of oxygen redox reaction. Synchrotron X‐ray absorption near edge structure and X‐ray photoelectron spectroscopy studies demonstrate that the charge compensation is dominated by the oxygen redox reaction and Mn3+/Mn4+ redox reaction separately. In situ synchrotron X‐ray diffraction exhibits its zero‐strain feature during the cycling. Density functional theory calculations further deepen the understanding of the charge compensation by oxygen and manganese redox reactions and the immobility of the Mn ions in the material. These findings provide new ideas on searching for and designing materials with high capacity and high structural stability for novel energy storage systems.
Perinatal veterinary medicine‐related evaluation in hematological and serum biochemical profiles of experimental beagles throughout pregnancy and parturition
Authors: Kimura Tohru , Kotani Kazuhiko 
Published: December 2018

AbstractBackgroundThe aims of this study were (a) to ascertain age‐related changes in the reference values in hematological and serum biochemical examinations of beagles, and (b) to clarify the changes in these findings, including acute phase proteins and oxidative stress, throughout pregnancy and after parturition.MethodsClinicopathological parameters were measured in young beagles at 6, 9 and 12 months and in adult beagles aged from 24 to 60 months. Likewise, pregnant beagles were investigated throughout the pregnancy and after parturition.ResultsApparent age‐related changes were found in erythrocytic parameters during the growth and development of beagles. Most of the parameters (total protein, albumin, blood urea nitrogen, creatinine, urate, alkaline phosphatase (ALP) and creatine kinase (CK) exhibited age‐dependent transitions. White cell count significantly increased after 30 days of pregnancy. The values of erythrocytic parameters moderately decreased during the second half of the pregnancy. Triglycerides, total cholesterol, free cholesterol and phospholipid concentrations increased in the mid‐ and late stages of pregnancy. ALP, lactate dehydrogenase, CK and cholinesterase activities markedly increased during pregnancy and/or after parturition. C‐reactive protein (CRP) concentrations gradually increased and reached a maximum after 30‐40 days of pregnancy. Serum amyloid A (SAA) levels markedly increased at 30 days of pregnancy before subsiding, and then increased again 3 days after parturition. Reactive oxygen metabolites (d‐ROMs) showed significant increases after 30 and 40 days of pregnancy.ConclusionsReference values for hematological and serum biochemical examinations should be used for health evaluation of dogs, taking sex, age and the stage of pregnancy into consideration. Measurements of CRP, SAA and d‐ROM levels are also useful for assessing maternal conditions in mid‐pregnancy.