bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identification of the retrotalar pulley of the Flexor Hallucis Longus tendon
Authors: Tzioupis Chris , Oliveto Anthony , Grabherr Silke , Vallotton Jacques , Riederer Beat M. 
Published: July 2019

AbstractFunctional Hallux Limitus is the expression of the gliding restraint of the Flexor Hallucis Longus (Fhl) tendon, resulting in several painful syndromes. This impingement is located along the tract of the Fhl tendon at the level of its retrotalar tunnel sealed posteriorly by a fibrous pulley. This pulley, although poorly anatomically characterized, has been arthroscopically proven that its presence or resection plays a pivotal clinical role in the biomechanics of the lower leg, being the main restraint to the physiological movement of the Fhl tendon. The aim of our study was to identify and characterize this anatomical structure. Eleven cadaveric lower legs were initially assessed by computer tomography (CT) imaging, subsequently plastinated, dissected and histologically evaluated by use of Mayer's and Hematoxylin stain. We have shown that the retrotalar pulley of the Fhl shares the same histological characteristics with the retinaculum of the long fibularis muscle and the retinaculum of flexor digitorum muscle, thus it constitutes a different entity than the adjacent formations.
Accumulation by and without dispossession: Rural land use, land expropriation, and livelihood implications in China
Authors: Zhan Shaohua 
Published: July 2019

AbstractLand expropriation and peasant resistance in China have been widely noted, but the many cases in which peasants consent to give up land have drawn less attention. This paper conceptualizes and examines an alternative development practice: accumulation without dispossession (AWD), a concept first developed by Gillian Hart and Giovanni Arrighi. AWD may arise if accumulation takes place without (completely) depriving rural producers of the right to assets and benefits. The paper examines multiple forms of AWD and makes two main arguments. First, land expropriation does not necessarily lead to dispossession if peasants are compensated with valuable flats, commercial venues, and/or secure jobs. Due to its positive effects on social equality and livelihood security, AWD may offer an alternative vision in the era of neoliberal dispossession. Second, the outcome of land expropriation in China has varied substantially across space and time. In general, there has been a shift away from AWD in the 1980s following the neoliberal reform in the 1990s, but in the recent decade, there has been some movement back towards AWD due to peasant protests, though only to a limited degree. Nevertheless, the majority of peasants losing land have not received compensation sufficient to sustain a secure livelihood.
Capitalist development in hostile conjunctures: War, dispossession, and class formation in Turkey
Authors: Karatasli Sahan Savas , Kumral Sefika 
Published: July 2019

AbstractThis article analyses how periods of geopolitical conflict and violence have affected the development of capitalism and class formation in Turkey. We argue that all major episodes of conflict, violence and war—from forced displacement and ethnic cleansing of the non‐Muslims in the late 19th and the early 20th century, to Kurdish secessionist warfare in the 1990s and the Syrian Civil War—have become major historical turning points in the development of historical capitalism in Turkey. These “hostile conjunctures” transformed capitalism through their direct and indirect effects on dispossession, class formation, and capital accumulation. Although each of these conflicts produced a violent dispossession process, none of them resembled the rural dispossession process in England. To make sense of Turkey's experience, we turn our attention to what we call the “Castilian/Spanish road,” and what Lenin called the “Junker/Prussian road” and the “farmers/American road.” Our analysis shows that these differential paths of dispossession, class formation, and capital accumulation have produced highly variegated rather than uniform outcomes. We conclude that we are living in a new “hostile conjuncture,” which is pregnant to a major structural crisis and is generating the preconditions of another historical transformation in the way capitalism operates.
A new strategy for taste masking on bitter drug by other combined drug in fixed-dose combination: bitterness of Amlodipine besylate could be masked efficiently by Valsartan
Authors: Kojima Honami , Nakamura Saki , Haraguchi Tamami , Yoshida Miyako , Habara Masaaki , Ikezaki Hidekazu , Uchida Takahiro 
Published: July 2019

Abstract

Objectives
The aim of this study was to evaluate the bitterness of amlodipine besylate (AML) combined with other five antihypertensive drugs: alacepril, benazepril, hydrochlorothiazide, telmisartan (TEL) and valsartan (VAL), which have possibility of usage as a fixed-dose combination (FDC) drugs.

Methods
The bitterness of individual six drugs and AML combined with each of the five drugs was evaluated using taste sensor SA402B (Intelligent Sensor Technology Inc.). AML combined with TEL or VAL was evaluated by taste sensor and human gustatory sensation tests. The interaction between AML with TEL or VAL was evaluated by 1H-NMR.

Key findings
The bitterness of AML was significantly decreased by addition of VAL, whereas it remained unchanged by the addition of TEL in taste sensor and human gustatory sensation test. In the 1H-NMR spectrum of AML with VAL, signal shifts of protons in AML were observed compared to that in AML alone. On the other hand, in the 1H-NMR spectrum of AML with TEL, signal shifts of protons in AML were not observed.

Conclusions
It was suggested that when VAL was mixed with AML, the electrostatic interactions between positive charged amino group of AML and negative charged tetrazole group of VAL were caused, and thereby led the suppression the bitterness of AML.
Association of A‐FABP gene polymorphism and mRNA expression with intramuscular fat content (IMF) in Baicheng‐You chicken
Authors: Wang Yong , Liu Wenqiang , Hang Chao , Du Yiqiang , Chen Ying , Xing Jinming , Gao Jun , Qiu Dexin 
Published: July 2019

AbstractThis study aims to assess the association of polymorphisms and mRNA expression of adipocyte‐type fatty acid‐binding protein (A‐FABP) with intramuscular fat (IMF) in the breast muscle (BM) and leg muscle (LM) of Baicheng‐You chickens (BYCs). A total of 180 chickens, including sixty black Baicheng‐You chickens (BBYCs), sixty silky Baicheng‐You chickens (SBYCs) and sixty white Baicheng‐You chickens (WBYCs), were reared from 1 to 120 day. A polymerase chain reaction–single‐strand conformation polymorphism strategy (PCR‐SSCP) was used to detect the polymorphism of the A‐FABP gene in the first exon, and the C51T silent mutational site was found. The IMF content with the AA genotype was significantly higher than that with the AG genotype (p = 0.0473) in the LM of WBYC. Thus, this site could be taken as a molecular marker in selecting a higher IMF content of LM in WBYC. A‐FABP gene mRNA expression in the BM and LM of BYCs was detected, and a significant positive correlation was observed in the LM of WBYC. These findings provide fundamental data that might be useful in further study of the role of the A‐FABP gene in IMF content and fatty metabolism in chickens.
Genetic diversity of genotype 6 HCV infections in France: Epidemiology and consequences for treatment strategy
Authors: Pronier Charlotte , Fontaine Hélène , Dorival Céline , Carrat Fabrice , Pol Stanislas , Thibault Vincent ,   the AFEF/ANRS Hepather study group
Published: July 2019

AbstractGenotype‐6 hepatitis C virus (GT6‐HCV) exhibits a high genetic diversity. GT6 prevalence, diversity and real‐life response to treatment were studied among 14 603 HCV mono‐infected patients from the French ANRS‐CO22‐Hepather cohort. NS3, NS5A and NS5B‐HCV genes were amplified and sequenced for all GT6‐infections identified in the database. Following phylogenic characterization, resistance‐associated substitution polymorphisms were identified. GT6‐infected patients (n = 36; 0.25%) did not differ from patients infected with other genotypes with regard to gender, age or liver fibrosis. GT6e was the most prevalent (27.8%), followed by 6a (22.2%), 6q (11.1%) and 6o (8.3%). Each subtype p and xc were found in two patients (5.6%) and subtypes f/h/r and t were each detected in one patient. Four strains (11.1%) clustered with unclassified reference sequences. Concordant genotype determination throughout NS3, NS5A and NS5B‐genes is consistent with lack of recombination within this genomic region. All, but three patients were born in Asia, Cambodia (44.4%), Vietnam (38.9%) or Laos (8.3%). GT6a were found in 42.8% of Vietnamese and 6e in 37.5% of Cambodian. GT6q, 6p and 6r were only found in Cambodian patients. Resistance‐associated polymorphisms for each DAA classes were identified in baseline sequences. Twenty‐seven patients were treated with sofosbuvir‐based combinations and 3 with glecaprevir/pibrentasvir. All treated patients, whether naïve or previously treated, achieved a sustained viral response. In conclusion, GT6‐infections are uncommon in France and their genetic diversity likely reflects infection within the country of origin. Despite residue variability at DAA resistance‐associated positions, sustained viral response was obtained in all treated patients.
The ECHO model proved to be a useful tool to increase clinicians' self‐effectiveness for care of patients with Hepatitis C in Argentina
Authors: Mendizabal Manuel , Ridruejo Ezequiel , Ceballos Susana , Sixto Marcela , Billordo Ariel , Gadea Claudia , Mengarelli Silvia , Alonso Cristina , Palazzo Ana , De María Luis , Bruno Andrés , Perez Daniela , Piñero Federico , Deltrozzo Verónica , Mendoza Carlos , Figueroa Sebastián , Manero Estela , Villa Marina , Barreyro Fernando , Moreno Valeria , Vilar José , Murga Dolores , Fernandez Marcelo , O´Flaherty Martin , Arora Sanjeev , Silva Marcelo ,   the Latin American Liver Research, Educational, Awareness Network (LALREAN)
Published: July 2019

AbstractThe ECHO model was developed to expand access to medical care for populations with HCV infection in underserved areas. We aimed to compare HCV treatment outcomes in community‐based clinics with the Austral University Hospital (AUH) and to assess improvement in physician knowledge and skills. In October 2015, we established an HCV ECHO clinic at the AUH in Buenos Aires. To evaluate the impact of this programme, we conducted a prospective cohort study comparing treatment for HCV infection at the AUH with healthcare providers from different Argentinean provinces. A survey evaluating skills and competence in HCV care was administered, and results were compared. The primary endpoint was sustained virologic response (SVR) and under direct‐acting antivirals. Since the implementation of ECHO clinics, a total of 25 physicians participated in at least one session (median 10.0; IQR 3.0‐18.0). SVR rates (n = 437 patients) were 94.2% (95% CI 90.4‐96.8) in patients treated at AUH clinic (n = 227/242) and 96.4% (95% CI 92.7‐98.5) in those treated at ECHO sites (n = 188/195), with a nonsignificant difference between sites, 2.2% SVR difference (95% CI −0.24‐0.06; P = 0.4). We also found a significant improvement in all the evaluated skills and abilities. Replicating the ECHO model helped to improve participants' skills in the management of HCV achieving similar SVR rates. ECHO model was demonstrated to be an effective intervention able to multiply and expand HCV treatment, a critical barrier to access to care that needs to be solved if we are committed with WHO goals to eliminate HCV by 2030.
Autism as a Form of Life: Wittgenstein and the Psychological Coherence of Autism
Authors: Chapman Robert 
Published: July 2019

AbstractAutism is often taken to be a specific kind of mind. The dominant neuro‐cognitivist approach explains this via static processing traits framed in terms of hyper‐systemising and hypo‐empathising. By contrast, Wittgenstein‐inspired commentators argue that the coherence of autism arises relationally, from intersubjective disruption that hinders access to a shared world of linguistic meaning. This paper argues that both camps are unduly reductionistic and conflict with emerging evidence, due in part to unjustifiably assuming a deficit‐based framing of autism. It then develops a new Wittgensteinian account—autism as a different form of life—which avoids these issues. Rather than autistic systemising being the basis of autistic cognition, it is taken to be a reaction to pre‐epistemic and semantic anxieties that come with developing as a minority within a different form of life. This re‐framing can provide a coherent account of the autistic mind, and has significant conceptual, practical, and ethical implications.
Freedom as Non‐Domination and Widespread Prejudice
Authors: Costa M. Victoria 
Published: July 2019

AbstractThis paper offers an answer to an objection to Phillip Pettit’s neo‐republican account of freedom as non‐domination raised by Sharon Krause. The objection is that widespread prejudice, such as systemic racism or sexism, generates significant obstacles to individuals’ free agency but that neo‐republicanism fails to explain why these obstacles reduce freedom. This is because neo‐republicanism defines domination in terms of the capacity for arbitrary interference, but many prejudiced actions do not involve physical coercion, threats, or any other behavior typically described as types of interference. The paper discusses three strategies to account for the impact of widespread prejudice on the domination of groups. It argues that the most plausible strategy redefines domination in terms of behavior that is prima facie wrong and lacks appropriate checks. Such behavior includes interference but also includes prejudiced actions, such as failing to select the most qualified candidate for a job.
A barley stripe mosaic virus‐based guide RNA delivery system for targeted mutagenesis in wheat and maize
Authors: Hu Jiacheng , Li Shaoya , Li Zhaolei , Li Huiyuan , Song Weibin , Zhao Haiming , Lai Jinsheng , Xia Lanqin , Li Dawei , Zhang Yongliang 
Published: July 2019

SummaryPlant RNA virus‐based guide RNA (gRNA) delivery has substantial advantages compared to that of the conventional constitutive promoter‐driven expression due to the rapid and robust amplification of gRNAs during virus replication and movement. To date, virus‐induced genome editing tools have not been developed for wheat and maize. In this study, we engineered a barley stripe mosaic virus (BSMV)‐based gRNA delivery system for clustered regularly interspaced short palindromic repeat (CRISPR)/Cas9‐mediated targeted mutagenesis in wheat and maize. BSMV‐based delivery of single gRNAs for targeted mutagenesis was first validated in Nicotiana benthamiana. To extend this work, we transformed wheat and maize with the Cas9 nuclease gene and selected the wheat TaGASR7 and maize ZmTMS5 genes as targets to assess the feasibility and efficiency of BSMV‐mediated mutagenesis. Positive targeted mutagenesis of the TaGASR7 and ZmTMS5 genes was achieved for wheat and maize with efficiencies of up to 78% and 48%. Our results provide a useful tool for fast and efficient delivery of gRNAs into economically important crops.
Crosstalk between epigenetic silencing and infection by tobacco rattle virus in Arabidopsis
Authors: Diezma‐Navas Laura , Pérez‐González Ana , Artaza Haydeé , Alonso Lola , Caro Elena , Llave César , Ruiz‐Ferrer Virginia 
Published: July 2019

SummaryDNA methylation is an important epigenetic mechanism for controlling innate immunity against microbial pathogens in plants. Little is known, however, about the manner in which viral infections interact with DNA methylation pathways. Here we investigate the crosstalk between epigenetic silencing and viral infections in Arabidopsis inflorescences. We found that tobacco rattle virus (TRV) causes changes in the expression of key transcriptional gene silencing factors with RNA‐directed DNA methylation activities that coincide with changes in methylation at the whole genome level. Viral susceptibility/resistance was altered in DNA (de)methylation‐deficient mutants, suggesting that DNA methylation is an important regulatory system controlling TRV proliferation. We further show that several transposable elements (TEs) underwent transcriptional activation during TRV infection, and that TE regulation likely involved both DNA methylation‐dependent and ‐independent mechanisms. We identified a cluster of disease resistance genes regulated by DNA methylation in infected plants that were enriched for TEs in their promoters. Interestingly, TEs and nearby resistance genes were co‐regulated in TRV‐infected DNA (de)methylation mutants. Our study shows that DNA methylation contributes to modulate the outcome of viral infections in Arabidopsis, and opens up new possibilities for exploring the role of TE regulation in antiviral defence.
Conifers depend on established roots during drought: results from a coupled model of carbon allocation and hydraulics
Authors: Mackay D. Scott , Savoy Philip R. , Grossiord Charlotte , Tai Xiaonan , Pleban Jonathan R. , Wang Diane R. , McDowell Nathan G. , Adams Henry D. , Sperry John S. 
Published: July 2019

Summary

Trees may survive prolonged droughts by shifting water uptake to reliable water sources, but it is unknown if the dominant mechanism involves activating existing roots or growing new roots during drought, or some combination of the two.

To gain mechanistic insights on this unknown, a dynamic root‐hydraulic modeling framework was developed that set up a feedback between hydraulic controls over carbon allocation and the role of root growth on soil–plant hydraulics. The new model was tested using a 5 yr drought/heat field experiment on an established piñon‐juniper stand with root access to bedrock groundwater.

Owing to the high carbon cost per unit root area, modeled trees initialized without adequate bedrock groundwater access experienced potentially lethal declines in water potential, while all of the experimental trees maintained nonlethal water potentials. Simulated trees were unable to grow roots rapidly enough to mediate the hydraulic stress, particularly during warm droughts. Alternatively, modeled trees initiated with root access to bedrock groundwater matched the hydraulics of the experimental trees by increasing their water uptake from bedrock groundwater when soil layers dried out.

Therefore, the modeling framework identified a critical mechanism for drought response that required trees to shift water uptake among existing roots rather than growing new roots.
Evolving together, evolving apart: measuring the fitness of rhizobial bacteria in and out of symbiosis with leguminous plants
Authors: Burghardt Liana T. 
Published: July 2019

SummaryMost plant–microbe interactions are facultative, with microbes experiencing temporally and spatially variable selection. How this variation affects microbial evolution is poorly understood. Given its tractability and ecological and agricultural importance, the legume–rhizobia nitrogen‐fixing symbiosis is a powerful model for identifying traits and genes underlying bacterial fitness. New technologies allow high‐throughput measurement of the relative fitness of bacterial mutants, strains and species in mixed inocula in the host, rhizosphere and soil environments. I consider how host genetic variation (G × G), other environmental factors (G × E), and host life‐cycle variation may contribute to the maintenance of genetic variation and adaptive trajectories of rhizobia – and, potentially, other facultative symbionts. Lastly, I place these findings in the context of developing beneficial inoculants in a changing climate.
Loneliness among older people living in care homes in Sri Lanka
Authors: Wijesiri H. S. Maliga S. K. , Samarasinghe Kerstin , Edberg Anna‐Karin 
Published: July 2019

AbstractAim and objectivesThe aim of this study was to explore loneliness in older people (aged 65+) living in care homes in Colombo, Sri Lanka.BackgroundLoneliness, defined as the subjective, unwelcome feeling of the lack or loss of companionship, is known to be associated with old age, especially among older people living in care homes. Although several studies have shown that loneliness is highly prevalent, we lack knowledge about older people's personal experience of loneliness when residing in a care home and the strategies that older people use by themselves on a day‐to‐day basis to alleviate loneliness.MethodsThe participants (n = 75) were randomly selected from three different types of care homes: governmental, non‐governmental and private, and loneliness was screened using the Revised University of California–Los Angeles (R‐UCLA) Loneliness Scale. The 15 participants with the highest score on the loneliness scale were purposively selected for individual interviews.ResultsThe median loneliness score was 45 (range 20–80); no significant differences concerning loneliness were found between the care homes. No differences concerning loneliness were found for any demographic variable except marital status. Loneliness was experienced as coping with inner pain, which older people described as emotional suffering caused by feeling abandoned from the family network and fettered to the care home, anxious about their future and depressed. Participants managed their loneliness by accepting their loneliness, practising religion, staying in touch with family, engaging in daily activities and participating in social activities.ConclusionReliable and socio‐culturally validated tools for screening loneliness and culturally applicable interventions targeting factors associated with loneliness are necessary in the care of older people residing in care homes. A person‐centred approach involving family or significant others is recommended in clinical practice, and an increase in the number of nurses with specialist education in geriatric nursing seems urgent.
BK viremia and nephropathy in pediatric renal transplant recipients
Authors: Hamasaki Yuko , Dolan Niamh M. , Cubitt David , Breuer Judith , Sebire Neil J. , Marks Stephen D. 
Published: July 2019

AbstractThe renal survival rate of pediatric renal transplant recipients (pRTR) has improved with the use of modern immunosuppressive agents; however, the incidence of post‐transplantation viral infection has increased. This study investigated the incidence of BK viremia and BK viral–associated nephropathy (BKVAN) in pRTR. One‐hundred‐and‐thirty‐four pRTR were divided into two groups: group 1 (n = 20, 14.9%) comprised those who were prospectively followed with longitudinal analyses after renal transplantation in the time period from May 2007 to June 2008, while group 2 (n = 114, 85.1%) cross‐sectional study of those who were transplanted from January 1994 to April 2007. The mean ages at transplantation in groups 1 and 2 were 10.6 ± 4.7 years and 7.8 ± 4.5 years, respectively. BK viremia was detected in four (20.0%) patients in group 1, and seven (6.1%) in group 2 (P = 0.04), with increased incidence associated with induction therapy. The median time to detection of BK viremia after transplantation was 44 days in group 1 and 142 days in group 2. BKVAN was diagnosed in three patients (two in group 1 and one in group 2). All three patients diagnosed with BKVAN were receiving tacrolimus, mycophenolate mofetil, and corticosteroids as maintenance immunosuppression. Reducing immunosuppression resulted in reduced BK viremia. Monitoring for BK viremia and BKVAN is important in pRTR being treated with the current immunosuppressive regimen. The first line of treatment for BK viremia remains careful reduction of immunosuppression and close monitoring of renal allograft function.