bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identification of Novel Genes and Variations Associated to Glycolytic Potential Based on Pig Model
Authors: Wu Wangjun , Zhang Zengkai , Chao Zhe , Li Bojiang , Ning Caibo , Jiang Aiwen , Dong Chao , Wei Wei , Chen Jie , Liu Honglin 
Published: July 2018

ABSTRACTIn livestock, glycolytic potential (GP) is a critical indicator for evaluating the meat quality. To date, two major genes protein kinase AMP-activated γ3 non-catalytic subunit gene (PRKAG3) and phosphorylase kinase catalytic subunit gamma 1(PHKG1), and corresponding cause mutations influencing GP have been confirmed in pigs. Therefore, the aim of this study to identify the novel candidate genes and variations related to GP-related traits using a four-hybrid pig model [Pietrain (P)× Duroc (D)] ×[(Landrace) ×(Yorkshire)]. We totally constructed six RNA-seq libraries using longissimus dorsi (LD) muscles, and each library contained two higher GP (H) or two lower GP (L) individuals. A total of 525, 698 and 135 differentially expressed genes (DEGs) were identified between H11 vs L11, H9 vs L9, and H5 vs L5 groups using PossionDis method, respectively. Notably, we found 97 non-redundant DEGs were mapped to GP related QTLs from three paired comparison groups. Moreover, 69 DEGs were identified between H (H11, H9 and H5) and L (L11, L9 and L5) groups using NOIseq method. Additionally, 1,076 potential specific SNPs were figured out between H and L groups, and approximately 40 large Indels with a length ≥ 5bp were identified in each sequencing library. In conclusion, our data provide foundation for further confirming the key genes and the functional mutations affecting GP-related traits in pigs, and also pave the way for elucidating the underling molecular regulatory mechanisms of glycogen metabolism in future study. Moreover, this study might provide valuable information for study on human glycogen storage diseases.
Interactive innovative tool for early diagnosis of global pre-crisis processes (based on measurement and assessment of the virtual intellectual capital)
Authors: Vahanyan Grigori Arshaluys , Vahanyan Hovhannes , Ghazaryan Margarita 
Published: July 2018

PurposeThe purpose of this paper is to present the great importance and impact of the virtual intellectual capital (VIC) in the frameworks of digital economics, e-governance and business, e-trading and commerce, virtual organizations and enterprises, and information communication technologies development (based on the comparative case studies of the world, Russian and Armenian economics). These conditions increase the importance of the measurement and assessment of the VIC.Design/methodology/approachThe research findings are obtained through the method of comparative analysis of the complex models of the VIC. The features are studied through measuring and assessing the VIC parameters of virtual representations on the internet. The data are complemented through virtual cluster analysis, a multidimensional statistical procedure that collects data containing information on facility selection. Three cluster groups are used in the study: the clusters of the TNCs and their virtual representations; the clusters of the network of the leading innovation centers and their virtual representations; and the clusters of the leading universities and their virtual representations.FindingsThe paper establishes the research findings of the growth forecasts of the IC clusters in the world, Russian and Armenian economic processes. This is extremely important to ensuring sustainable growth of the country’s competitiveness, economy and general welfare. The paper proposes a new model of the virtual national or transnational intellectual capital (VNTIC). The VNTIC model presents three general components: virtual representations of universities, innovation center networks and transnational corporations in global networks. The research findings show that the interactive innovative tools (IIT) can be used for early diagnosis of the world economic and financial processes.Originality/valueThe authors developed for the first time the IIT for measuring and assessing the three intellectual capital components. The paper presents a new approach and a more reliable tool for short-term forecasting at global and national levels based on QI ranking of the VIC clusters of the commercial enterprises, universities and networks of innovation centers.
Emerging organizational parameters and their roles in implementation of organizational change
Authors: Aslam Usman , Muqadas Farwa , Imran Muhammad Kashif , Saboor Abdul 
Published: July 2018

PurposeThe purpose of this paper is to investigate new emerging organizational parameters and their roles in successful change implementation. These organizational parameters are rarely investigated especially in the context of organizational change (OC) in private and public sector organizations.Design/methodology/approachIn cumulative, 403 valid responses have been obtained randomly from public sector workers by using self-administered questionnaires.FindingsThe results reveal that knowledge sharing regarding incremental and radical changes can helpful for effective OC implementation. Findings highlight the significant role of emotional and social intelligence in managing resistance and bringing openness to change in these organizations. It is also found that social media has become an important emerging organizational parameter to foster effective communication and knowledge sharing during OC implementation. Apart from the direct effects, readiness to change has multiple effects coupled with emerging organizational parameters to implement change successfully.Research limitations/implicationsThe results of the current study offer diversified implications for theory, practice and global society. The theoretical base is taken from the well-known theories of management (i.e. Lewin’s three-step model, field theory, intelligence theory, cost-effective theory, social exchange theory, social network theory and social penetration theory). Emerging organizational parameters that have a potential impact on effective change implementation are identified. The findings suggest that global organizations should have to initiate effective networking structure using social media applications and social intelligence skills to remain connected and get positive responses about change formulation and implementation decision.Originality/valueA majority of studies have presented the research model on OC implementation in the context of developed countries, which form 30 percent of the world’s population, mostly the Americas and Europe. It is observed that a developing country, such as Pakistan, has a culture that is based on power distance, collectivism and more political influence as compared to developed countries. Triandis et al. (1980) argued that any theoretical contribution without considering the cultural aspect can lead to bias findings. There is limited research available in the world that is conducted to examine the interactive effects of readiness to change on the relationship between effective change implementation, knowledge sharing, intelligence and social media. These findings are useful to plan and execute OC using new emerging organizational parameters.
Workplace bullying across the globe: a cross-cultural comparison
Authors: Salin Denise , Cowan Renee , Adewumi Oluwakemi , Apospori Eleni , Bochantin Jaime , D’Cruz Premilla , Djurkovic Nikola , Durniat Katarzyna , Escartín Jordi , Guo Jing , Išik Idil , Koeszegi Sabine T. , McCormack Darcy , Monserrat Silvia Inés , Zedlacher Eva 
Published: July 2018

Purpose
The purpose of this paper is to analyze cross-national and cross-cultural similarities and differences in perceptions and conceptualizations of workplace bullying among human resource professionals (HRPs). Particular emphasis was given to what kind of behaviors are considered as bullying in different countries and what criteria interviewees use to decide whether a particular behavior is bullying or not.

Design/methodology/approach
HRPs in 13 different countries/regions (n=199), spanning all continents and all GLOBE cultural clusters (House et al., 2004), were interviewed and a qualitative content analysis was carried out.

Findings
Whereas interviewees across the different countries largely saw personal harassment and physical intimidation as bullying, work-related negative acts and social exclusion were construed very differently in the different countries. Repetition, negative effects on the target, intention to harm, and lack of a business case were decision criteria typically used by interviewees across the globe – other criteria varied by country.

Practical implications
The results help HRPs working in multinational organizations understand different perceptions of negative acts.

Originality/value
The findings point to the importance of cultural factors, such as power distance and performance orientation, and other contextual factors, such as economy and legislation for understanding varying conceptualizations of bullying.
An empirical study of elder abuse in the state of Uttar Pradesh of India
Authors: Patel Avanish Bhai , Mishra Anindya J. 
Published: July 2018

Purpose
Elder abuse is the matter of grave concern in recent times in India. Today, older people are facing the abusive behaviour such as maltreatment, mental and physical torture and heedless ignominy from the family and the society. The purpose of this paper is to examine the nature of elder abuse in Indian socio-cultural context and also focuses on the causes of elder abuse and abusers.

Design/methodology/approach
Mixed method design has been applied in this paper. The study has been conducted from October 2012-January 2013 on a sample of 220 older people living in both rural and urban areas of Lucknow, India. The data have been analysed through descriptive and narrative analysis.

Findings
The study finds that the emotional abuse is more common among the older people, which raises the feeling of insecurity, depression and isolation. The study also points out that the respect, honour, status and authority which were enjoyed by the elderly in the traditional society, have gradually started declining. Moreover, the study finds that the family members, do not provide proper food, clothing and medical facilities in rural areas.

Research limitations/implications
Since the sample of older respondents was small and focused on those living in a particular area of one state, the authors cannot generalise from this study to include the great diversity of experience and difference in perceptions among the older people even within a particular state. However, widespread and diverse types of accounts of elder abuse were reported even in these settings, which can help indicate areas for future research and policies.

Originality/value
This is an original paper, which is based on the experiences of older people living in rural-urban areas and discussed the elder abuse in socio-cultural context.
Internationalization process through an opportunity lens
Authors: Rezende Sérgio , Galdino Kátia , Lamont Bruce 
Published: July 2018

Purpose
The purpose of this paper is to establish a conversation between international business and international entrepreneurship literatures by analyzing if and how international opportunities are related to the internationalization process of the firm.

Design/methodology/approach
This paper reports finding from a backward-looking longitudinal, qualitative, embedded case study of an internationalized Brazilian firm, covering all 13 foreign markets where the firm has operated over 18 years.

Findings
Modal shifts within foreign markets were rare. Over time, the firm learned how to refine, rather than change, the servicing modes within each foreign market; it also learned how to better develop internal and exploitative opportunities, manage a portfolio of servicing modes across foreign markets, and use more complex mode servicing packages. Overall, international opportunities and the internationalization process of the firm were inextricably connected.

Research limitations/implications
The authors acknowledge limitations related to the statistical generalizability of the research method and suggest that statistical validation is needed as the research on opportunities and the internationalization process of the firm progresses.

Practical implications
Internationalizing firms should carefully consider the choice of entry mode in foreign markets. They should also understand that learning is not necessarily associated with change.

Originality/value
The authors show that the internationalization process of a traditional firm can be analyzed through an opportunity lens. This means associating characteristics of international opportunities with mode continuation and modal shifts in all foreign markets where the firm operates.
The impact of knowledge management systems on innovation
Authors: Elmorshidy Ahmed 
Published: July 2018

Purpose
This paper aims to examine and validate the effect of knowledge management systems (KMS) on innovation.

Design/methodology/approach
Survey data from 392 employees working in private and public organizations in the state of Kuwait were collected and used to test the proposed research model and hypotheses through structural equation modeling.

Findings
This study finds that system quality, information quality and service quality of KMS have a positive effect on perceived usefulness and perceived ease of use of the system, and in turn, they have a positive effect on actual use of KMS which leads to net benefit represented in an increased innovation for employees who use the KMS. Employees (users of the system) indicated that the use of the system helped them to improve their work, come up with new ways to conduct work, discover new solutions to solve problems, accomplish more complex tasks in less time and communicate in a better way with other employees.

Practical implications
The findings of this study analyzed the elements of KMS that influence innovation in public and private organizations at the individual level. This should be helpful for the designers of KMS to focus on those success factor elements when building KMS, which should make it easy for individuals to acquire knowledge, use it, share it and thus become more innovative and successful in the work they do and the decisions they make. The study also shows a positive relationship between usefulness, ease of use and attitude toward using KMS. Developers of KMS should also take these guidelines in consideration when designing a responsive KMS.

Originality/value
Both knowledge and innovation are considered as crucial sources for sustaining the competitive advantage for organizations. However, despite this, knowledge management (KM) and innovation have established themselves as separate fields and distinct areas of research. However, although KM has a strong relationship with innovation, it is unclear if the research literature in these two fields converge. There is a lack of research studies that deal with interrelation of KM and innovation in organizations. This study is among the first to attempt to fill this gap by empirically investigating the effect of KMS on innovation in both private and public organizations in the state of Kuwait.
Lower birthweight and left‐/mixed‐handedness are associated with intensified age‐related sex steroid decline in men. Findings from the Men's Health 40+ Study
Authors: Hoppler S. , Walther A. , La Marca‐Ghaemmaghami P. , Ehlert U. 
Published: July 2018

SummaryIn males, age‐related decline in free testosterone (T) and dehydroepiandrosterone (DHEA) by 2–3% per year has been reported. Estradiol (E2) and progesterone (P) seem to decrease as well, but to a lesser extent. Lower sex steroid levels in men have been related to physical and mental symptoms. Low birthweight and left‐/mixed‐handedness (L/MH) are indicators of an adverse fetal environment during pregnancy, and both have been linked to morbidity in later life. The aim of this study is to examine the relationship between lower birthweight as well as L/MH and age‐related sex steroid decline. In a cross‐sectional study design, saliva samples were collected under standardized conditions from healthy men for subsequent steroid hormone analysis using standard luminescence immunoassays. T (M = 67.57 pg/mL), DHEA (M = 247.91 pg/mL), E2 (M = 1.29 pg/mL), and P (M = 28.20 pg/mL) have been quantified leading to a final sample of 256 men providing complete data on sex hormones (MAge=57.8; SDAge = 10.8). Information on participants’ birthweight was obtained from birth reports (N = 134), and participants were asked about their handedness (right‐handed, left‐handed, mixed‐handed) (N = 256). Multivariate‐adjusted linear regression models relating each sex hormone individually and the principal component of declining steroid hormones (DSH)—an integrated hormonal parameter—with handedness and birthweight did not identify significant associations except for handedness and E2. Moderation analysis using robust regression accounting for bias due to influential data points detected a significant association between age and DSH for handedness (β = −0.0314, p = 0.040) but only a trend for birthweight (β = 0.0309, p = 0.073). For lower birthweight, a trend toward intensified age‐related sex steroid decline in men was observed, while for L/MH, a significant association with intensified age‐related sex steroid decline was identified. These results indicate that L/MH and potentially also lower birthweight might be considered as early risk factors for endocrine health in later life.
Extent of intraluminal exfoliated malignant cells during surgery for colon cancer: Differences in cell abundance ratio between laparoscopic and open surgery
Authors: Kobayashi Shinichiro , Inoue Yusuke , Fujita Fumihiko , Ito Shinichiro , Yamaguchi Izumi , Nakayama Masahiko , Kanetaka Kengo , Takatsuki Mitsuhisa , Eguchi Susumu 
Published: July 2018

AbstractIntroductionLaparoscopic colectomy with intracorporeal anastomosis is a minimally invasive surgical procedure for patients with colon cancer. However, there are often concerns about the presence of intraluminal exfoliated malignant cells in the intracorporeal anastomosis. This study investigated the relationship between colon cancer surgery and the incidence of intraluminal exfoliated malignant cells and several factors.MethodsEighty‐nine consecutive patients who underwent either laparoscopic or open colectomy were prospectively studied in our department between 2007 and 2011. Before anastomosis, the proximal and distal lumens were irrigated with normal saline and subjected to cytological examination.ResultsIn 27 patients (30.3%), exfoliated cancer cells were detected. On the distal side, the frequency of positive cytology findings of exfoliated malignant cells was significantly lower in the laparoscopic colectomy group than in the open colectomy group (P = 0.01). In the laparoscopic colectomy group, there were no cases of positive cytology findings for exfoliated malignant cells more than 100 mm from the primary tumor. The incidence of positive cytology more than 100 mm from the primary tumor was significantly lower than the incidence of positive cytology less than 100 mm from the primary tumor (P = 0.04).ConclusionsExfoliated malignant cells were detected at anastomosis sites in patients with colon cancer. On the distal side, laparoscopic colectomy may prevent the development of exfoliated malignant cells.
Cross‐group friendships and psychological well‐being: A dual pathway through social integration and empowerment
Authors: Bagci Sabahat C. , Turnuklu Abbas , Bekmezci Eyup 
Published: July 2018

This study investigated the associations between cross‐group friendships and psychological well‐being among a sample of physically disabled adults. A total of 269 disabled people (Mage = 39.13, SD = 13.80; 114 females, 152 males, 3 unknown) completed questionnaires including the quality of their friendships with non‐disabled people, perceived majority group's attitudes towards the minority group, collective self‐esteem, collective action tendencies, own outgroup attitudes, and psychological well‐being. Findings demonstrated that disabled people's cross‐group friendships were directly and indirectly associated with higher levels of psychological well‐being via two routes: one by promoting perceived majority attitudes which consequently led to more positive own outgroup attitudes (well‐being through social integration hypothesis) and the other by leading to higher levels of collective self‐esteem which enhanced collective action tendencies (well‐being through empowerment hypothesis). Findings offer important insights into the study of cross‐group friendships in relation to the psychological well‐being of stigmatized minority group members.
The promise of reward crowdfunding
Authors: Gutiérrez‐Urtiaga María , Sáez‐Lacave María‐Isabel 
Published: July 2018

AbstractResearch Question/IssueWe study reward crowdfunding (RC), the most innovative segment of the crowdfunding market, where, instead of a debt or equity contract, fund providers are promised some good or service in the future in exchange for their contribution to the funding of the investment project under a contract that does not penalize the creator's failure to deliver. The existing economic and legal literature is puzzled by the platform's use of this seemingly inefficient contract where a standard pre‐sale contract would appear to work better.Research Findings/InsightsCounterintuitively, we prove that the no‐penalty contract is the optimal contract between creators of unknown talent and early adopters of their products when creators can benefit from being discovered as talented and from the goodwill generated by delivering on their promise to early adopters.Theoretical/Academic ImplicationsOur analysis contributes to understanding RC by showing that the no‐penalty RC contract, far from being an inefficiency, is a contractual innovation specifically designed for talent discovery. We also contribute to the literature on relationship contracts, showing that even in a one‐shot game, it is possible to sustain a contract in the desire to build a reputation that will be useful in a future contract with a third party.Practitioner/Policy ImplicationsOur analysis has important policy implications on how backers should be protected. Standard measures of consumer or investor protection may be counterproductive.
Groundwater Quality and Hydraulic Fracturing: Current Understanding and Science Needs
Authors: Soeder Daniel J. 
Published: July 2018

AbstractHydraulic fracturing (fracking) is a process used for the stimulation and production of ultra‐low permeability shale gas and tight oil resources. Fracking poses two main risks to groundwater quality: (1) stray gas migration and (2) potential contamination from chemical and fluid spills. Risk assessment is complicated by the lack of predrilling baseline measurements, limited access to well sites and industry data, the constant introduction of new chemical additives to frack fluids, and difficulties comparing data sets obtained by different sampling and analytical methods. Specific recommendations to reduce uncertainties and meet science needs for better assessment of groundwater risks include improving data‐sharing among researchers, adopting standardized methodologies, collecting predrilling baseline data, installing dedicated monitoring wells, developing shale‐specific environmental indicators, and providing greater access to field sites, samples, and industry data to the research community.