bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sex differences in recovery from postoperative sarcopenia during adjuvant CAPOX therapy for colorectal cancer
Authors: Nozawa Hiroaki , Abe Shinya , Abe Kentaro , Yokota Yumi , Hori Shunsuke , Yakabe Mitsutaka , Sasaki Kazuhito , Emoto Shigenobu , Yokoyama Yuichiro , Sonoda Hirofumi , Murono Koji , Matsuzaki Hiroyuki , Nagai Yuzo , Shinagawa Takahide , Akishita Masahiro , Ishihara Soichiro 
Published: October 2024

Abstract
Background
Women are predisposed to develop intolerance to cancer chemotherapy. Sarcopenia and chemotherapy are mutually related. Women are generally intolerable to chemotherapeutics such as 5-fluorouracil. Although adjuvant oxaliplatin-based chemotherapy, e.g. CAPOX is commonly used to treat colorectal cancer, its effects on patients in terms of sarcopenia and sex remain unknown. We investigated sex disparities in the impacts of CAPOX on body composition in this study.

Methods
We conducted a prospective study on diagnostic metrics used for sarcopenia in colorectal cancer patients receiving adjuvant CAPOX. Evaluations of the nutritional status by the Mini-Nutritional Assessment (MNA), gait speed, grip strength, skeletal muscle mass, fat mass, and bone mineral content using a body composition analyzer were performed in the first, fourth, and eighth cycles of CAPOX (first, second, and third measurements, respectively).

Results
Among 80 eligible patients, 61 completed four CAPOX cycles. The median differences in MNA, gait, grip strength, muscle mass, fat mass, and bone mineral content between the first and second measurements for men (n = 35) and women (n = 26) were + 10.5% and + 2.9% (p = 0.067), + 4.5% and − 2.6% (p = 0.16), + 1.8% and + 2.8% (p = 0.66), + 2.7% and + 1.3% (p = 0.021), + 4.5% and + 3.5% (p = 0.59), and + 3.3% and + 0.0% (p = 0.006), There were no sex differences in comparisons of the above metrics between the first and third measurements in 34 patients who completed eight CAPOX cycles (19 wen and 15 women).

Conclusions
Early cycles of adjuvant CAPOX may have a negative impact on the postoperative recovery of several metrics for diagnosing sarcopenia in women.
Camillo Golgi’s contributions to the anatomic basis of sensitivity in tendons
Authors: Garbarino Maria Carla , Pisani Antonio , Biggiogera Marco , Mazzarello Paolo 
Published: October 2024

Abstract
Between 1878 and 1880 Camillo Golgi, professor of Histology and General Pathology at the University of Pavia, studied the termination of the nerves inside the tendons, near their muscular insertion. He defined two fundamental categories of corpuscles. The first type, which he called muscle-tendon terminal organs, was morphologically characterized by spindle structures which at one end seemed to relate to the muscle fibers while at the other end they gradually merged with the tendon bundles. Golgi discovered that these structures received from one to four myelinated nerve fibers, which lost their myelin sheath as they entered the bundle, within which they divided dichotically, ending in a large number of terminal arborizations that had the appearance of reticular intertwines. In the superficial thickness of the tendon, near the muscle, Golgi also noticed a second category of corpuscles, which he described as claviform bodies or formations similar to Pacinian bodies. In 1890 Vittorio Mazzoni precisely defined their morphological characteristics. These corpuscles were later called Golgi muscle-tendon organs and Golgi-Mazzoni corpuscles. On the basis of their position and histological appearance, Golgi also correctly hypothesized their physiological role: to be receptors of muscular tension for the muscle-tendon organs and transducers of sensitivity to touch and pressure for the Golgi-Mazzoni corpuscles.
Role of clipping in aneurysmal subarachnoid hemorrhage: a post hoc analysis of the Earlydrain trial
Authors: Mertens Robert , Wolf Stefan , Wessels Lars , Hecht Nils , Gempt Jens , Meyer Bernhard , Ringel Florian , Rohde Veit , Vajkoczy Peter ,   for the Earlydrain Study Group
Published: October 2024

AbstractThe choice between clipping and coiling of ruptured cerebral aneurysms in subarachnoid hemorrhage (SAH) remains controversial. The recently published Earlydrain trial provides the opportunity to analyze the latest clip-to-coil ratio in German-speaking countries and to evaluate vasospasm incidence and explorative outcome measures in both treatment modalities. We performed a post hoc analysis of the Earlydrain trial, a multicenter randomized controlled trial investigating the use of an additional lumbar drain in aneurysmal SAH. The decision whether to clip or to coil the ruptured aneurysm was left to the discretion of the participating centers, providing a real-world insight into current aneurysm treatment strategies. Earlydrain was performed in 19 centers in Germany, Switzerland, and Canada, recruiting 287 patients with aneurysmal SAH of all severity grades. Of these, 140 patients (49%) received clipping and 147 patients (51%) coiling. Age and clinical severity based on Hunt-Hess/WFNS grades and radiological criteria were similar. Clipping was more frequently used for anterior circulation aneurysms (55%), whereas posterior circulation aneurysms were mostly coiled (86%, p < 0.001). In high-volume recruiting centers, 56% of patients were treated with clipping, compared to 38% in other centers. A per-year analysis showed a stable and balanced clipping/coiling ratio over time. Regarding vasospasm, 60% of clipped versus 43% of coiled patients showed elevated transcranial Doppler criteria (p = 0.007), reflected in angiographic vasospasm rates (51% vs. 38%, p = 0.03). In contrast to the Earlydrain main results establishing the superiority of an additional lumbar drain, explorative outcomes after clipping and coiling measured by secondary infarctions, mortality, modified Rankin Score, Glasgow Outcome Scale Extended, or Barthel-Index showed no significant differences after discharge and at six months. In clinical practice, aneurysm clipping is still a frequently used method in aneurysmal SAH. Apart from a higher rate of vasospasm in the clipping group, an exploratory outcome analysis showed no difference between the two treatment methods. Further development of periprocedural treatment modalities for clipped ruptured aneurysms to reduce vasospasm is warranted.
Drought field experiments: how to adapt rainout shelters to agroforestry?
Authors: Bachakdjian Lory , Blanchet Guillaume , Gosme Marie , Bourdoncle Jean-François , Dupraz Christian 
Published: October 2024

AbstractAgroforestry could be a major strategy to adapt agriculture to climate change, thanks to the microclimate effects of trees and improved infiltration. However, the experimental validation of these claims is scarce. In this methodological review, we discuss options for the experimental simulation of drought conditions in agroforestry field experiments, comparing it with strategies adopted in natural, agricultural, or forestry ecosystems. We classify rainout shelters used in field experiments according to mobility, completeness of rain interception and height of rainout shelter. We show that specificities of agroforestry systems create constraints and require compromises in the design and operation of rainout shelters. We conclude that large rainout shelters, which induce drought for both the trees and the crops while limiting artifacts and biases, would be most relevant for studying the resistance of agroforestry systems to drought. Unfortunately, the review of rainout shelters already used in agroforestry systems reveals a lack of rainout shelters capable of intercepting rain on both trees and crops, achieving total rain interception, while being relatively low-cost and manageable by a small team. Therefore, we benchmark three novel rainout shelter designs that we tested in a mature agroforestry system under Mediterranean climatic conditions. We discuss their advantages and disadvantages in terms of both scientific and operational aspects. While compromises had to be done between experimental design, risks of artifact/bias, effectiveness, ease of installation, operation and maintenance, and agricultural management, these prototypes are starting points for achieving well-performing rainout shelters and testing the effects of drought in agroforestry experiments.
20 years review of the multi actor multi criteria analysis (MAMCA) framework: a proposition of a systematic guideline
Authors: Huang He , Heuninckx Shary , Macharis Cathy 
Published: October 2024

Abstract
Multi-criteria Decision Making (MCDM) involves evaluating alternatives based on a comprehensive set of conflicting criteria, often requiring the involvement of varied decision makers. This has led to the emergence of stakeholder-based multi-criteria group decision-making (MCGDM) frameworks. However, traditional MCGDM frequently overlooks the interactions and trade-offs among different actors and criteria. The Multi-actor Multi-criteria Analysis (MAMCA), developed in 2000, provides a transparent decision-making process explicitly considering these interrelationships. It allows diverse stakeholder groups to represent their priorities, thereby enhancing their understanding of their own and others’ positions. Over the past two decades, MAMCA has seen a significant rise in popularity and has been widely applied in diverse contexts, proving valuable as both a decision-making and stakeholder engagement tool. However, our analysis of publications on cases in which MAMCA was applied over the years shows that considerable variation exists in the overall process approach, contingent upon the specific goals and context. To address these variations, this paper proposes a modularized MAMCA structure, complemented by systematic application guidelines, to aid future users in navigating the process steps and identifying the most suitable methods for each step. Additionally, future research directions are suggested for potential enhancements to the MAMCA framework by integrating varied methodologies.
Smartphone-driven centrifugal microfluidics for diagnostics in resource limited settings
Authors: Lapins Noa , Akhtar Ahmad S. , Banerjee Indradumna , Kazemzadeh Amin , Pinto Inês F. , Russom Aman 
Published: October 2024

Abstract
The broad availability of smartphones has provided new opportunities to develop less expensive, portable, and integrated point-of-care (POC) platforms. Here, a platform that consists of three main components is introduced: a portable housing, a centrifugal microfluidic disc, and a mobile phone. The mobile phone supplies the electrical power and serves as an analysing system. The low-cost housing made from cardboard serves as a platform to conduct tests. The electrical energy stored in mobile phones was demonstrated to be adequate for spinning a centrifugal disc up to 3000 revolutions per minute (RPM), a rotation speed suitable for majority of centrifugal microfluidics-based assays. For controlling the rotational speed, a combination of magnetic and acoustic tachometry using embedded sensors of the mobile phone was used. Experimentally, the smartphone-based tachometry was proven to be comparable with a standard laser-based tachometer. As a proof of concept, two applications were demonstrated using the portable platform: a colorimetric sandwich immunoassay to detect interleukin-2 (IL-2) having a limit of detection (LOD) of 65.17 ng/mL and a fully automated measurement of hematocrit level integrating blood-plasma separation, imaging, and image analysis that takes less than 5 mins to complete. The low-cost platform weighing less than 150 g and operated by a mobile phone has the potential to meet the REASSURED criteria for advanced diagnostics in resource limited settings.
Invariant manifolds near $$L_1$$ and $$L_2$$ in the Sun–Jupiter elliptic restricted three-body problem II: the dynamics of comet Oterma
Authors: Duarte Gladston , Jorba Àngel 
Published: October 2024

Abstract
Comet 39P/Oterma is known to make fast transitions between heliocentric orbits outside the orbit of Jupiter and heliocentric orbits inside that of Jupiter. In this paper, the dynamics of comet Oterma is modelled and fitted in the Planar Elliptic RTBP. Using the computations presented in Duarte(Celest. Mech. Dyn. Astron 136:26, 2024), we look for the invariant objects around

$$L_1$$

L
1

and

$$L_2$$

L
2

, which in the case of the Planar Elliptic RTBP is invariant tori and their stable and unstable manifolds that are the skeleton that guides Oterma in its rapid transition.
Higher education and the public good in Finland
Authors: Brewis Elisa 
Published: October 2024

Abstract
This paper discusses understandings of higher education and the public good in the context of Finland. A lexical-based comparison of public goods terminology reveals that the Finnish translation of public good—julkishyödyke—is used in comparatively recent (post-1970s) scholarship, mainly limited to the fields of economics, forestry and agriculture. It is notably absent in discussions of higher education. Instead, universities’ contribution to the public good is expressed as sivistys, service, social impact and national development. The second half of the paper discusses findings from a qualitative study of university staff and policymaker understandings of public good(s) (n = 21). Participants framed the contribution of universities to the public good as sivistys, service and social impact and also highlighted the dimension of social equality. These goods were viewed as applicable to local, national and global levels, flowing both out of and into Finland, thus benefiting everyone. As such, responses were closely aligned with the UNESCO (2015) definition of higher education as a global common good. Recent higher education policies that are based on the logic of higher education as a private good (education export, tuition fees for international students) threaten this model, revealing a conflict in the role of the state as protector of the public good at the national level and promoter of higher education as a private good at the global level.
Higher education and national and global public good(s) in Ontario, Canada
Authors: Brewis Elisa , Brotherhood Thomas , Yang Lili 
Published: October 2024

Abstract
This paper explores contributions to public good(s) in higher education in Ontario, Canada. In a break from the trend of this special issue, this paper does not offer a comprehensive national study. Rather, it is based on a multiple case study conducted in a single predominantly English-speaking province, Ontario, drawing on 19 semi-structured interviews conducted in 2019 with policymakers and university staff, including those in academic and executive roles. The analysis offers novel insights into contemporary understandings of public good(s) in general, and Ontarian higher education’s contributions to the public good, and its relationship with the state and global community. Participants highlighted three dimensions of the public good: economic, knowledge-based, and social. While participants from the provincial and national spheres focused more on narratives of province- or nation-building through economic development and social mobility, university staff additionally highlighted knowledge-based contributions, emphasizing an educated citizenry, critical debate, and curiosity-driven research.
Ultimate Rationality. Husserl on Critical Position-Taking (Stellungnahme) in the Theoretical and Axiological Spheres
Authors: Delamare Alexis 
Published: October 2024

AbstractAs a fervent rationalist, Husserl placed considerable emphasis on the delineation of the different levels of reason. Its highest form, he contends, is position-taking (Stellungnahme) understood as a critical stance towards a positional act P. Specifically, such a Stellungnahme is a three-step procedure: the subject, possibly motivated by a passive discordance, starts by questioning P (active doubt); she then seeks to validate P by returning to its originary fulfillment (active search for evidence); finally, she ratifies such a fulfillment in an act of acknowledgment (active decision), thereby making P a permanent personal conviction. In the literature, the role of position-taking in the formation of persons has been aptly emphasized, but insufficient attention has been paid to its intrinsic structure and concrete functioning; furthermore, the few existing studies on this topic are limited to the theoretical domain. The aim of this paper is to fill this twofold gap by providing a comprehensive account of critical Stellungnahme in both the intellectual and the axiological spheres, drawing especially on the manuscripts from the Studien zur Struktur des Bewusstseins. The first part examines Stellungnahme in the theoretical realm, underscoring its teleological orientation towards justification and the active role played by the subject in it. The second part shows how this procedure can be extended to rationalize value-experiences, by elucidating the nature of affective evidence and approval (Billigung). Finally, the third part demonstrates how a particular value, that of knowledge, can concretely pass the axiological position-taking and thus be recognized as an actual value.
Ergodic and Chaotic Properties of the Heat Equation
Authors: Rudnicki Ryszard 
Published: October 2024

AbstractWe consider a semiflow generated by the heat equation on the half-line with zero Neumann boundary condition. If the initial functions are from some weighted space X, then we prove that there exists an invariant mixing measure and X is the topological support of this measure. This result implies chaotic properties of the semiflow.
Reciprocal Relationships Between Parental Involvement and Academic Performance in Early Adolescence: A Two-Year Longitudinal Study in China
Authors: Yang Yi 
Published: October 2024

AbstractPrevious literature has focused on the overall influence of parental involvement on adolescents’ academic performance, while less attention has been accorded to the reciprocal relationships between different forms of parental involvement and academic performance across gender. The present study examined the reciprocal associations between different forms of parental involvement and adolescents’ academic performance using nationally representative data. A total of 9449 Chinese adolescents (47.82% girls, Mage = 13.21, SD = 0.65, 91.20% Han Ethnicity) have participated in the two-year and two-wave longitudinal study. Cross-lagged model results indicated reciprocal associations between parent-reported involvement and academic performance. Autonomy-supportive parental involvement in Grade 7 was positively associated with better academic performance in Grade 8, while behavioral control was negatively associated with later academic performance. Parental socialization practices vary by adolescent’s gender. Compared with girls, boys experienced increased parental behavioral control in response to better academic performance. The findings reflect the persistence of stereotypical gender expectations and gender socialization in contemporary China.
Preparation of monolithic silica HPLC columns with truss-structured skeletons and embedded surfactant-templated mesopores
Authors: Detani Takanori , Morisato Kei , Ohira Masayoshi , Nakanishi Kazuki 
Published: October 2024

AbstractMonolithic macro/mesoporous silica gels have been prepared via a sol-gel process using triblock copolymer Pluronic P123 (EO20PO70EO20) as a structure-directing agent. In this synthesis, P123 not only induces phase separation to form macroporous structure but also acts as a supramolecular template to form mesopores with precisely controlled shape and size. Obtained was a monolithic silica composed of continuous truss-like columnar skeletons in which cylindrical mesopores are arranged in a 2D-hexagonal symmetry. These monolithic silica gels have extremely high porosity approaching 90% and exhibited high specific surface area and sharp pore size distribution as revealed by N2 sorption measurements. Combinations of the initial composition and the post-gelation treatment on wet gels allowed the control of physical properties of meso- and macropore structures. The monolithic HPLC columns prepared using these silica gels surface-modified by ODS (octadecylsilyl) ligands gave as many as 140,000 theoretical plates/m for the separation of alkylbenzenes in a reversed-phase mode. Very weak dependence of height equivalent to theoretical plate, H, on the mobile phase velocity was also recognized in comparison with conventional particle-packed columns.
Graphical Abstract
Learning differentiable logic programs for abstract visual reasoning
Authors: Shindo Hikaru , Pfanschilling Viktor , Dhami Devendra Singh , Kersting Kristian 
Published: October 2024

AbstractVisual reasoning is essential for building intelligent agents that understand the world and perform problem-solving beyond perception. Differentiable forward reasoning has been developed to integrate reasoning with gradient-based machine learning paradigms. However, due to the memory intensity, most existing approaches do not bring the best of the expressivity of first-order logic, excluding a crucial ability to solve abstract visual reasoning, where agents need to perform reasoning by using analogies on abstract concepts in different scenarios. To overcome this problem, we propose NEUro-symbolic Message-pAssiNg reasoNer (NEUMANN), which is a graph-based differentiable forward reasoner, passing messages in a memory-efficient manner and handling structured programs with functors. Moreover, we propose a computationally-efficient structure learning algorithm to perform explanatory program induction on complex visual scenes. To evaluate, in addition to conventional visual reasoning tasks, we propose a new task, visual reasoning behind-the-scenes, where agents need to learn abstract programs and then answer queries by imagining scenes that are not observed. We empirically demonstrate that NEUMANN solves visual reasoning tasks efficiently, outperforming neural, symbolic, and neuro-symbolic baselines.
Vortices on cylinders and warped exponential networks
Authors: Gupta Kunal , Longhi Pietro 
Published: October 2024

AbstractWe study 3d $$\mathcal {N}=2$$

N
=
2

U(1) Chern–Simons-Matter QFT on a cylinder $$C\times \mathbb {R}$$

C
×
R

. The topology of C gives rise to BPS sectors of low-energy solitons known as kinky vortices, which interpolate between (possibly) different vacua at the ends of the cylinder and at the same time carry magnetic flux. We compute the spectrum of BPS vortices on the cylinder in an isolated Higgs vacuum, through the framework of warped exponential networks, which we introduce. We then conjecture a relation between these and standard vortices on $$\mathbb {R}^2$$

R

2

, which are related to genus-zero open Gromov–Witten invariants of toric branes. More specifically, we show that in the limit of large Fayet–Iliopoulos coupling, the spectrum of kinky vortices on C undergoes an infinite sequence of wall-crossing transitions and eventually stabilizes. We then propose an exact relation between a generating series of stabilized CFIV indices and the Gromov–Witten disk potential and discuss its consequences for the structure of moduli spaces of vortices.