bluuebunny/crossref_metadata_2025_split huggingface dataset:
Eating disorders symptoms in sexual minority women: A systematic review
Authors: Meneguzzo Paolo , Collantoni Enrico , Gallicchio Davide , Busetto Paolo , Solmi Marco , Santonastaso Paolo , Favaro Angela 
Published: April 2018

AbstractBackgroundAlthough the literature consistently shows increased levels of psychological distress in the gay population, less evidence—and with contrasting findings—is available with regard to lesbian women. The aim of the present study is to review the literature in the eating disorders (EDs) field in order to provide further data on the frequency of EDs symptoms in sexual minority women.MethodA systematic review of the studies identified by electronic database search (PubMed, Ovid, ScienceDirect, and Google Scholar) up to August 2017.ResultsFourty‐five studies were found, conducted on 372,256 women. Only 7 studies investigated patients with lifetime diagnosis of ED. As for the symptomatology of EDs, 39 studies were found, which presented huge differences in the scales used for the assessment (e.g., Eating Disorders Inventory and Eating Attitudes Test‐26).ConclusionsA higher number of diagnoses of EDs were found in sexual minority women, with a symptomatology characterized by higher occurrence of binge eating and purging, as well as lower body dissatisfaction and drive for thinness, compared with heterosexual peers.
A numerical comparison of protective measures against external fire spread
Authors: Nilsson Markus , Husted Bjarne , Mossberg Axel , Anderson Johan , McNamee Robert Jansson 
Published: April 2018

SummaryThe impact of different passive protective measures against external vertical fire spread was investigated using the numerical tool Fire Dynamics Simulator (FDS). The numerical study was divided into a validation study and a comparative analysis. The validation study was performed to evaluate FDS as a calculation tool for modelling external vertical fire spread and was conducted using experimental results from a large‐scale fire test done on a SP FIRE 105 test rig at SP, Sweden. It was concluded that FDS 6.2.0 could reproduce the experimental results with a reasonable level of detail. In the comparative analysis, the impact on the external fire from a smaller apartment was studied in FDS with different configurations of horizontal projections and spandrels in the building exterior. Also, the effects of an upper and lower facade set‐back configuration were studied. The results show that facade solutions based on a horizontal projection or an upper facade set‐back configuration result in comparable or better protection compared with a defined spandrel height. The results also show that a spandrel height of at least 1.2 m can be replaced by a 60‐cm‐deep horizontal projection, given that the balcony is wider than the underlying opening.
Management of newly diagnosed high‐risk and intermediate‐risk follicular lymphoma with 90Y ibritumomab tiuxetan in a phase II study
Authors: Berinstein Neil L. , Pennell Nancy M. , Weerasinghe Rashmi , Buckstein Rena , Piliotis Eugenia , Imrie Kevin R. , Chodirker Lisa , Cussen Mary‐Anne , Miles Ellen , Reis Marciano D. , Ghorab Zeina , Cheung Matthew C. 
Published: April 2018

AbstractFive‐year overall survival for high‐risk Follicular Lymphoma International Prognostic Index follicular lymphoma is only approximately 50% compared with 90% for low risk. To evaluate an approach to improve upon this poor outcome, we completed an exploratory phase II trial of intensified treatment for patients with intermediate and high‐risk follicular lymphoma. Front‐line treatment with chemo‐immunotherapy consisting of rituximab, cyclophosphamide, vincristine, doxorubicin, and prednisone was followed by radio‐ immunotherapy with 90‐Yttrium ibritumomab tiuxetan consolidation, and 2 years of rituximab maintenance. The 5‐year overall survival for intermediate and high‐risk patients was 88% and 83%, respectively. Of 33 enrolled patients, 3 were off study before receiving radio‐immunotherapy. Three months post radio‐immunotherapy, 28/33 (85%) patients had achieved complete response including 6 patients who had only a partial response to chemo‐immunotherapy and converted to complete response after radio‐immunotherapy. The 5‐year progression‐free survival for intermediate and high risk was 79% and 58%, respectively. Nine of 19 patients with molecular markers patients remain in molecular and clinical complete remission with a median follow‐up of 48 months (range 3‐84 months). Post radio‐immunotherapy, hematologic toxicities were mostly grade 1 and 2. However, asymptomatic grade 3 or 4 thrombocytopenia and neutropenia occurred in 11%‐36% and 10%‐24% of patients, respectively. Myelodysplastic syndrome occurred in 1 patient 4 years post treatment. Whereas many patients had prolonged B‐cell reduction and low immunoglobulin levels post treatment, previous immunities to rubella were maintained. More aggressive upfront approaches such as this may benefit higher risk follicular lymphoma, but confirmatory trials are required. http://www.clinicaltrials.gov: NCT01446562.
A comparative transgene expression study between a protaplex and a rotaplex embedded lipid‐nano particles in murine derived dendritic cell
Authors: Shaheen Sharif M. , Azad A.K. , Mustafezur Rahman M. , Uddin Md. Jashim 
Published: May 2018

AbstractGene therapy depends on the perfect DNA delivery to the nuclear subdomain, where DNA should be orchestrated in a lipid based programmed packaging, like multi‐functional envelope type of nano device (MEND) and tetra lamellar multi‐functional envelope type of nano device (T‐MEND) published elsewhere. In both the packaging system, DNA has to make a complex (core) with a cationic polymer. It is important how about the effect of such a DNA/condenser core inside the programmed‐packaging reflects the transgene expression. Here we compared transgene expression of a firefly luciferase gene from both the protaplex (protamine‐DNA) and rotaplex (polyrotaxane‐DNA), packaged in MENDs. Dendritic cells were transfected with these nanoparticles and transgene expression, cell viability as well as antigen presentations were measured. Transgene expression from the MEND of protaplex was significantly higher in JAWs‐II cell (dendritic cell line) and bone marrow dendritic cell. Cell viability and antigen presentations from the protaplex were also prompt and better than that of polyplex, when T‐MEND package systems containing protaplex and rotaplex, were compared. Confocal microscopic studies of fluorescently labeled plasmid DNA reflected the evidence of ease decondensation of DNA from the protaplex than that of a rotaplex. Our results suggest that a natural DNA condenser (protamine in protaplex) prefers transgene expression better to those of synthetic polycationic condenser (polyrotaxane in rotaplex).
Analytical performance of the various acquisition modes in Orbitrap MS and MS/MS
Authors: Kaufmann Anton 
Published: April 2018

AbstractQuadrupole Orbitrap instruments (Q Orbitrap) permit high‐resolution mass spectrometry‐based full scan acquisitions and have a number of acquisition modes where the quadrupole isolates a particular mass range prior to a possible fragmentation and high‐resolution mass spectrometry‐based acquisition. Selecting the proper acquisition mode(s) is essential if trace analytes are to be quantified in complex matrix extracts. Depending on the particular requirements, such as sensitivity, selectivity of detection, linear dynamic range, and speed of analysis, different acquisition modes may have to be chosen. This is particularly important in the field of multi‐residue analysis (eg, pesticides or veterinary drugs in food samples) where a large number of analytes within a complex matrix have to be detected and reliably quantified. Meeting the specific detection and quantification performance criteria for every targeted compound may be challenging. It is the aim of this paper to describe the strengths and the limitations of the currently available Q Orbitrap acquisition modes. In addition, the incorporation of targeted acquisitions between full scan experiments is discussed. This approach is intended to integrate compounds that require an additional degree of sensitivity or selectivity into multi‐residue methods.
Micro‐Raman detection of the differentiation state of SH‐SY5Y cells grown on silicon and aluminium substrates
Authors: Ricci Maria , Sagini Krizia , Caponi Silvia , Urbanelli Lorena , Cornella Nicola , Macchi Paolo , Morresi Assunta , Emiliani Carla , Fioretto Daniele , Musio Carlo , Sassi Paola 
Published: April 2018

AbstractSH‐SY5Y cell line is a model for neural diseases originating from neuroblastoma, a paediatric embryonal malignancy that may differentiate and regress to a benign state. By monitoring the differentiation in single living cells, it could be possible to reach a better understanding of the process and, consequently, to develop new therapeutic approaches. In this work, we investigated the potential of Raman microspectroscopy to monitor biochemical changes in single living SH‐SY5Y cells treated with a combination of retinoic acid (RA) and brain‐derived neurotrophic factor to stimulate the differentiation toward a neuronal phenotype. The results show that the spectroscopic analysis is able to detect biochemical alterations consistent with the differentiation process. Moreover, we investigated also the influence of the cell culture substrate on the treatment outcome. Silicon and aluminium are 2 materials suitable for the spectroscopic analysis and of interest in neuroscience applications. Even though silicon has an ensured biocompatibility, it is subject to alterations after the treatment with RA. Aluminium revealed to be a cost‐effective cell culture substrate for the RA and brain‐derived neurotrophic factor treatment of SH‐SY5Y cells and particularly suitable for Raman microspectroscopy.
CARS microscopy of scytonemin in cyanobacteria Nostoc commune
Authors: Venckus Petras , Paliulis Skalvis , Kostkevičiene Jolanta , Dementjev Andrej 
Published: April 2018

AbstractThis paper deals with the study of scytonemin in cyanobacteria applying coherent anti‐Stokes Raman scattering (CARS) microscopy. The chemically specific CARS response from particular chemical compounds in the algae cell is usually weak because of their low concentration and is often overwhelmed by optical emissions from other cellular constituents. This report demonstrates that for scytonemin localized in cyanobacteria Nostoc commune, the vibrational response is sufficient for its reliable identification. Scytonemin is known as a sunscreen sheath enclosing the cells of microalgae against ultraviolet radiation. The effectiveness of CARS microscopy as a mapping technique with the aim to visualize the scytonemin sheath in a live culture such as cyanobacteria N. commune has been revealed.
Supersonic Shear Imaging Elastography in Skeletal Muscles: Relationship Between In Vivo and Synthetic Fiber Angles and Shear Modulus
Authors: Lima Kelly , Rouffaud Remi , Grégoire Jean‐Marc , Pereira Wagner , Oliveira Liliam F. 
Published: April 2018

ObjectivesTo verify a relationship between the pennation angle of synthetic fibers and muscle fibers with the shear modulus (μ) generated by Supersonic shear imaging (SSI) elastography and to compare the anisotropy of synthetic and in vivo pennate muscle fibers in the x2–x3 plane (probe perpendicular to water surface or skin).MethodsFirst, the probe of Aixplorer ultrasound scanner (v.9, Supersonic Imagine, Aix‐en‐Provence, France) was placed in 2 positions (parallel [aligned] and transverse to the fibers) to test the anisotropy in the x2–x3 plane. Subsequently, it was inclined (x1–x3 plane) in relation to the fibers, forming 3 angles (18.25 °, 21.55 °, 36.86 °) for synthetic fibers and one (approximately 0 °) for muscle fibers.ResultsOn the x2–x3 plane, μ values of the synthetic and vastus lateralis fibers were significantly lower (P < .0001) at the transverse probe position than the longitudinal one. In the x1–x3 plane, the μ values were significantly reduced (P < .0001) with the probe angle increasing, only for the synthetic fibers (approximately 0.90 kPa for each degree of pennation angle).ConclusionsThe pennation angle was not related to the μ values generated by SSI elastography for the in vivo lateral head of the gastrocnemius and vastus lateralis muscles. However, a μ reduction with an angle increase in the synthetic fibers was observed. These findings contribute to increasing the applicability of SSI in distinct muscle architecture at normal or pathologic conditions.
Flexible Supercapacitor Based on Inkjet‐Printed Graphene@Polyaniline Nanocomposites with Ultrahigh Capacitance
Authors: Diao Jianglin , Yuan Jia , Ding Ailing , Zheng Jiushang , Lu Zhisong 
Published: April 2018

AbstractThis work describes the fabrication of high‐performance all‐solid‐state supercapacitors based on covalently‐anchored reduced graphene oxide (RGO)@polyaniline (PANI) composites via an inkjet printing method. Morphological and chemical characterization data show that PANI nanoparticles are immobilized on graphene oxide (GO) nanosheets via covalent bonds. Sandwich‐structured and interdigitated supercapacitors are fabricated by printing the as‐prepared GO@PANI composites on flexible substrates, followed by a chemical reduction. The devices display high volumetric capacitances (258.5 F cm−3 at 1 mV s−1 for sandwich‐structured ones and 554 F cm−3 at 1 mV s−1 for interdigitated ones) and excellent cycling retention (2000 cycles >90%). Moreover, at the bending state, there are no significant changes on the device capacitances, indicating their great flexibility. The high‐performance devices can be further designed to produce special geometries and patterns. The work may provide a novel strategy to fabricate RGO@PANI composite‐based supercapacitors, which allows the end users to precisely deposit active materials according to their designs, for miniature and wearable electronics.
A new efficient approach to the characterization of D‐stable matrices
Authors: Pavani Raffaella 
Published: April 2018

The concept of D‐stability is relevant for stable square matrices of any order, especially when they appear in ordinary differential systems modeling physical problems. Indeed, D‐stability was treated from different points of view in the last 50 years, but the problem of characterization of a general D‐stable matrix was solved for low‐order matrices only (ie, up to order 4). Here, a new approach is proposed within the context of numerical linear algebra. Starting from a known necessary and sufficient condition, other simpler equivalent necessary and sufficient conditions for D‐stability are proved. Such conditions turn out to be computationally more appealing for symbolic software, as discussed in the reported examples. Therefore, a new symbolic method is proposed to characterize matrices of order greater than 4, and then it is used in some numerical examples, given in details.
A discrete polar Stockwell transform for enhanced characterization of tissue structure using MRI
Authors: Pridham Glen , Steenwijk Martijn D. , Geurts Jeroen J.G. , Zhang Yunyan 
Published: May 2018

PurposeThe purpose of this study was to present an effective algorithm for computing the discrete polar Stockwell transform (PST), investigate its unique multiscale and multi‐orientation features, and explore potentially new applications including denoising and tissue segmentation.Theory and MethodsWe investigated PST responses using both synthetic and MR images. Moreover, we compared the features of PST with both Gabor and Morlet wavelet transforms, and compared the PST with two wavelet approaches for denoising using MRI. Using a synthetic image, we also tested the edge effect of PST through signal‐padding. Then, we constructed a partially supervised classifier using radial, marginal PST spectra of T2‐weighted MRI, acquired from postmortem brains with multiple sclerosis. The classification involved three histology‐verified tissue types: normal appearing white matter (NAWM), lesion, or other, along with 5‐fold cross‐validation.ResultsThe PST generated a series of images with varying orientations or rotation‐invariant scales. Radial frequencies highlighted image structures of different size, and angular frequencies enhanced structures by orientation. Signal‐padding helped suppress boundary artifacts but required attention to incidental artifacts. In comparison, the Gabor transform produced more redundant images and the wavelet spectra appeared less spatially smooth than the PST. In addition, the PST demonstrated lower root‐mean‐square errors than other transforms in denoising and achieved a 93% accuracy for NAWM pixels (296/317), and 88% accuracy for lesion pixels (165/188) in MRI segmentation.ConclusionsThe PST is a unique local spectral density‐assessing tool which is sensitive to both structure orientations and scales. This may facilitate multiple new applications including advanced characterization of tissue structure in standard MRI.
Symmetric orthogonal approximation to symmetric tensors with applications to image reconstruction
Authors: Pan Junjun , Ng Michael K. 
Published: April 2018

SummaryThe main objective of this paper is to study an approximation of symmetric tensors by symmetric orthogonal decomposition. We propose and study an iterative algorithm to determine a symmetric orthogonal approximation and analyze the convergence of the proposed algorithm. Numerical examples are reported to demonstrate the effectiveness of the proposed algorithm. We also apply the proposed algorithm to represent correlated face images. We demonstrate better face image reconstruction results by combining principal components and symmetric orthogonal approximation instead of combining principal components and higher‐order SVD results.
Reciprocal loop of hypoxia‐inducible factor‐1α (HIF‐1α) and metastasis‐associated protein 2 (MTA2) contributes to the progression of pancreatic carcinoma by suppressing E‐cadherin transcription
Authors: Zhu Shuai , Deng Shijiang , He Chi , Liu Mingliang , Chen Hengyu , Zeng Zhu , Zhong Jianxin , Ye Zeng , Deng Shichang , Wu Heshui , Wang Chunyou , Zhao Gang 
Published: April 2018

AbstractMetastasis‐associated protein 2 (MTA2) is overexpressed in certain malignancies, and plays important roles in tumour metastasis and progression. The present study highlights the function of MTA2 in pancreatic carcinoma through its role as a deacetylator of hypoxia‐inducible factor‐1α (HIF‐1α) and a cotranscriptional factor for E‐cadherin expression. We found that overexpression of MTA2 promoted, and knockdown of MTA2 inhibited, the invasion and proliferation of pancreatic carcinoma cells both in vitro and in xenograft models in vivo. We also found that MTA2 is transcriptionally upregulated by HIF‐1α through a hypoxia response element (HRE) of the MTA2 promoter in response to hypoxia. Reciprocally, MTA2 deacetylates HIF‐1α and enhances its stability through interacting with histone deacetylase 1 (HDAC1). Consequently, HIF‐1α recruits MTA2 and HDAC1 to the HRE of the E‐cadherin promoter, by which E‐cadherin transcription is repressed. In agreement with these experimental results, MTA2 is positively associated with HIF‐1α, but inversely correlated with E‐cadherin, in pancreatic carcinoma samples. Moreover, data from The Cancer Genome Atlas on 172 pancreatic carcinomas indicate an association between high expression of MTA2 and short overall survival. Taken together, our study identifies MTA2 as a critical hub and potential therapeutic target to inhibit the progression and metastasis of pancreatic carcinoma. Copyright © 2018 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
Simple route for the preparation of graphene/poly(styrene‐b‐butadiene‐b‐styrene) nanocomposite films with enhanced electrical conductivity and hydrophobicity
Authors: Kepić Dejan P , Ristić Ivan S , Marinović‐Cincović Milena T , Peruško Davor B , Špitálsky Zdenko , Pavlović Vladimir B , Budimir Milica D , Šiffalovič Peter , Dramićanin Miroslav D , Mičušík Matej , Kleinová Angela , Janigová Ivica , Marković Zoran M , Todorović Marković Biljana M 
Published: April 2018

AbstractThis paper reports a simple route for the preparation of graphene/poly(styrene‐b‐butadiene‐b‐styrene) (SBS) nanocomposite films employing a vacuum filtration method. Graphene is exfoliated well by an electrochemical procedure and homogeneously dispersed in the polymer matrix. The prepared nanocomposite films were characterized by XRD, Fourier transform IR (FTIR) spectroscopy, X‐ray photoelectron spectroscopy (XPS), Raman spectroscopy, AFM and SEM. Morphological studies showed that graphene formed a smooth coating over the surface of SBS. The increase in graphene concentration induces the wrinkling of graphene sheets at the composite surface which causes a further increase in surface roughness. The FTIR, Raman and XPS spectra of graphene/SBS nanocomposite films indicate the strong interactions between graphene and the polymer matrix. According to the XRD patterns, introducing SBS into graphene did not modify the graphene structure additionally, i.e. the crystal lattice parameters do not depend on SBS content in graphene/SBS nanocomposite films. The graphene/SBS nanocomposite films also exhibited better hydrophobicity due to the increased surface roughness and lower sheet resistivity (reduced 10 times) compared to exfoliated graphene. © 2018 Society of Chemical Industry
Biobased epoxy resin derived from eugenol with excellent integrated performance and high renewable carbon content
Authors: Miao Jia‐Tao , Yuan Li , Guan Qingbao , Liang Guozheng , Gu Aijuan 
Published: April 2018

AbstractDeveloping biobased epoxy resin with high renewable carbon content and outstanding integrated performance is beneficial for both sustainable development and applications in cutting‐edge fields. Herein, a biobased epoxy monomer (TEUP‐EP) with high renewable carbon content (100%) was synthesized from renewable eugenol with a sustainable process; TEUP‐EP was then blended with 4,4′‐diaminodiphenylmethane (DDM) to develop a new biobased epoxy resin (TEUP‐EP/DDM). The integrated performance of TEUP‐EP/DDM resin was studied and compared with that of petroleum‐based diglycidyl ether of bisphenol A (DGEBA)/DDM resin. Compared with DGEBA/DDM resin, TEUP‐EP/DDM resin has much better integrated performance and not only exhibits a glass transition temperature about 26 °C higher and a 24.4% or 57% increased flexural strength or modulus, but also shows outstanding flame retardancy. Specifically, the limiting oxygen index increases from 26.5% to 31.4% and the UL‐94 grade improves from no rating to the V‐0 level; moreover, the peak heat release rate and total heat release decreased by 63.1% and 57.4%, respectively. All these results fully prove that TEUP‐EP/DDM is a novel biobased high performance epoxy resin. The mechanism behind these attractive integrated performances is discussed intensively. © 2018 Society of Chemical Industry