bluuebunny/crossref_metadata_2025_split huggingface dataset:
HER3-Mediated Resistance to Hsp90 Inhibition Detected in Breast Cancer Xenografts by Affibody-Based PET Imaging
Authors: Martins Carlos D. , Da Pieve Chiara , Burley Thomas A. , Smith Rhodri , Ciobota Daniela M. , Allott Louis , Harrington Kevin J. , Oyen Wim J.G. , Smith Graham , Kramer-Marek Gabriela 
Published: February 2018

Abstract
Purpose: Recent studies have highlighted a role of HER3 in HER2-driven cancers (e.g., breast cancer), implicating the upregulation of the receptor in resistance to HER-targeted therapies and Hsp90 inhibitors (e.g., AUY922). Therefore, we have developed an affibody-based PET radioconjugate that quantitatively assesses HER3 changes induced by Hsp90 inhibition in vivo.
Experimental Design: ZHER3:8698 affibody molecules were conjugated via the C-terminus cysteine to DFO-maleimide for 89Zr radiolabeling. The probe was characterized in vitro and in vivo in a panel of human breast cell lines and xenograft models with varying HER3 receptor levels. In addition, the radioconjugate was investigated as a tool to monitor the outcome of AUY922, an Hsp90 inhibitor, in an MCF-7 xenograft model.
Results: We demonstrated that 89Zr-DFO-ZHER3:8698 can track changes in receptor expression in HER3-positive xenograft models and monitor the outcome of AUY922 treatment. Our in vitro findings showed that MCF-7 cells, which are phenotypically different from BT474, develop resistance to treatment with AUY922 through HER3/IGF-1Rβ–mediated signaling. Of note, the lack of response in vitro due to HER3 recovery was confirmed in vivo using 89Zr-DFO-ZHER3:8698–based imaging. Upon AUY922 treatment, higher radioconjugate uptake was detected in treated MCF-7 xenografts, correlating with an AUY922-induced HER3 upregulation concomitant with an increase in IGF-1Rβ expression.
Conclusions: These data underline the potential of HER3-based PET imaging to noninvasively provide information about HER3 expression and to identify patients not responding to targeted therapies due to HER3 recovery. Clin Cancer Res; 24(8); 1853–65. ©2018 AACR.
New record of Munidopsis taiwanica (Decapoda, Anomura) from a mud volcano field in the Mariana Trench, with in-situ observations on habitat
Authors: Dong Dong , Li Xinzheng 
Published: February 2018

Squat lobsters are prevalent in chemosynthetic environments but have been insufficiently studied in mud volcano habitats. An abyssal species,Munidopsis taiwanicaOsawa, Lin & Chan, 2008 was recently collected in a mud volcano field in the Mariana Trench at a depth greater than 5000 m, which represents a new distributional record. Its diagnostic characters are presented in this study. In-situ observation suggested thatM. taiwanicawas closely associated with this chemosynthetic environment and probably exhibited camouflage behaviour by attaching seafloor sediments onto its body.Munidopsis taiwanicais the first confirmed species of squat lobster found in the mud volcano environment, and currently represents the deepest record (5491 m) of squat lobsters in the world.
Evidence-Based Analysis of Adjacent Segment Degeneration and Disease After LIF: A Narrative Review
Authors: Trivedi Nikunj N. , Wilson Sean M. , Puchi Luis A. , Lebl Darren R. 
Published: February 2018

Study Design: Narrative review. Objectives: The etiology of adjacent segment degeneration (ASDeg) and adjacent segment disease (ASDz) after lumbar interbody fusion (LIF) remains controversial. The aim of this narrative review was to provide an evidence-based analysis of the peer-reviewed literature on clinical studies of ASDeg and ASDz after LIF. Methods: A review was performed utilizing Medline, Embase, and Cochrane databases. Two reviewers independently extracted relevant data from each included study. Statistical comparisons were made when appropriate. Results: Nine articles that matched the inclusion and exclusion criteria were included. All the studies were Level III and retrospective. MINORS scores ranged from 9.5 to 13. Clinical outcomes were assessed in all 9 studies, but only 6 studies used validated outcomes measures. Only 6 studies reported values for both ASDeg and ASDz. ASDeg alone was reported in 3 studies. Due to the variability in the criteria for designation as ASDz (different radiographic modalities) and ASDeg (different outcomes measures), we were unable to calculate frequency-weighted mean values or compare the various surgical techniques. Conclusions: This review highlights the various limitations of the current literature on ASDeg and ASDz after lumbar fusion, specifically the absence of a rigorous definition and classification system and an extraordinary heterogeneity in methodology. There needs to be a fundamental shift in the current ASDeg and ASDz research landscape, toward a consensus, so that the high-level clinical research that is essential for treatment of spinal pathology may become available.
Βιβλιοκρισία:Ecclesiastical History and Nikephoros Kallistou Xanthopoulos, Proceedings of the International Symposium, Vienna, 15th-16th December 2011, ed. Chr. GASTGEBER and S. PANTEGHINI [Veröffentlichungen zur Byzanzforschung, 37], Wien 2015, 184 σελ.
Authors: ΚΙΑΠΙΔΟΥ Ειρήνη-Σοφία 
Published: February 2018

Βιβλιοκρισία:Ecclesiastical History and Nikephoros Kallistou Xanthopoulos, Proceedings of the International Symposium, Vienna, 15th-16th December 2011, ed. Chr. GASTGEBER and S. PANTEGHINI [Veröffentlichungen zur Byzanzforschung, 37], Wien 2015, 184 σελ.
Continuing Professional Development: The role of the paramedic in sepsis management
Authors: Higginson Ray , Williams Meirion , Parry Andy , Burrows Paul 
Published: February 2018

Overview Sepsis is a potentially life-threatening complication of an infection and involves a complex array of inflammatory responses. Sepsis is usually caused by bacterial, viral, or fungal infections that are likely to develop into pneumonia, abdominal infections and kidney infections. Sepsis has gained increasing publicity in recent years and is now a strong focus of clinical education following the launch of the ‘Surviving Sepsis’ campaign. Paramedics need to understand the pathophysiological process associated with sepsis, and how these may present in patients.
‘Le geste architectural’; Symbolism and authority in the case of the Centre Beaubourg
Authors: Psilopoulos Angelos 
Published: February 2018

Architecture seems often imbued with the notion of “gesture.” The term is mentioned in abundance both when architecture is seen as a discipline and when it is seen as a social practice. Arguments about it can be found in an artefact as well as in an act of design. In this context it may be revealed as an object to be claimed (i.e., a fetish), or stand for a trace or a carrier of meaning. Thus, in a wider scope, gesture may be discussed as a persistent – if not necessary – theme in the field’s culture.This essay examines “gesture” as a mediator between society (including culture and power) and the practice of architecture. This will be discussed within the framework of the competition for the Centre Beaubourg (later known as Centre Georges Pompidou). The heated discourse revolving around the expression “le geste architectural,” including the proposal to design the building literally as an open hand and thereby as a gesture of offering, will be explored. We will thus show how “gesture” simultaneously creates a multifaceted existence: at once as a token of validity and a symbol of truth and beauty, as well as representing the very danger of banality. Furthermore, we will show how the Centre itself – to which was attributed the character of a feat – becomes a “political gesture” carrying the sperm that spawned the type of “heroic architecture” that is so distinctive to the Fifth Republic. Finally, we will revisit “gesture” as a token taking part in a conundrum where the modern ideal ends up substitutinggenuinenesswithgenius; and we will see this binary relationship in connection to all the “gestures” we discuss in the case of the Centre Beaubourg.On these premises we will propose that, before we ask to define “gesture” by its content, it is important to see it first and foremost for what itdoes; namely, that it acts as a nominator, and thereby as a mediator, and even a weaver, of the collective between architecture and society. This shift in perspective is critical, as it reveals that gesture plays a more dynamic role than any doctrine would like to have it. Ultimately, we hope to show that gesture can be seen as taking an integral part in the very fabric of architecture, instead of merely playjng a role in one of its many histories.This essay is based on existing literature as well as original research conducted in the archives of the Centre Georges Pompidou – to which we extend our gratitude for the access.
Learning, robust monetary policy and the merit of precaution
Authors: André Marine Charlotte , Dai Meixing 
Published: February 2018

Abstract
We study in a New Keynesian framework the consequences of adaptive learning for the design of robust monetary policy. Compared to rational expectations, the fact that private sector follows adaptive learning gives the central bank an additional intertemporal trade-off between optimal behavior in the present and in later periods thanks to its ability to manipulate future inflation expectations. We show that adaptive learning imposes a more restrictive constraint on monetary policy robustness to ensure the dynamic stability of the equilibrium than under rational expectations but strengthens the argument in favor of a more aggressive monetary policy when the central bank fears for model misspecifications.
Progressive Philanthropie: Geht das überhaupt zusammen? – Einige Gedanken zum Geben für den sozialen Wandel
Authors: Fiedler Matthias 
Published: February 2018

Zusammenfassung
Progressive Philanthropie – Geht das überhaupt zusammen? Dieser Artikel beschreibt, welche Herausforderungen die Philanthropie bearbeiten muss, wenn sie an einer wirklichen sozialen, ‚ökologischen und gerechten Transformation arbeiten will. Er führt aus, wie nur durch eine gezielte Arbeit für einen echten sozialen Wandel, bei der eine klare Theory of Change und eine kritische Reflexion des Zusammenhangs von Geld, Macht, und Philanthropie im Zentrum stehen, wichtige Impulse für Veränderung setzen und diese dann auch mutig, verlässlich und dauerhaft durchführen kann.
Crystal structure of dibromido-carbonyl-(η6-p-cymene)osmium(II), C11H14Br2OOs
Authors: Clayton Hadley S. 
Published: February 2018

Abstract
C11H14Br2OOs, monoclinic, P21/c (no. 14), a = 10.3844(5) Å, b = 6.7833(3) Å, c = 19.0379(9) Å, β = 102.143(2)°, V = 1311.03(11) Å3, Z = 4, R
gt(F) = 0.0258, wR
ref(F
2) = 0.0582, T = 173(2) K.
Effects of nanofillers on the characteristics and performance of PEBA-based mixed matrix membranes
Authors: Kardani Rokhsare , Asghari Morteza , Mohammadi Toraj , Afsari Morteza 
Published: February 2018

Abstract
Mixed matrix membranes (MMMs) with superior structural and functional properties provide an interesting approach to enhance the separation properties of polymer membranes. As a matter of fact, MMMs combine the advantages of both components; polymeric continuous phase and nanoparticle dispersed phase. Generally, the separation performance of polymeric membranes suffers from an upper-performance limit. Hence, the incorporation of nanoparticles helps to overcome such limitations. Block copolymers such as poly(ether-block-amide) (PEBA) composed of immiscible soft ether segments as well as hard amide segments have been shown as excellent materials for the synthesis of membranes. Consequently, PEBA membranes have been extensively used in scientific research and industrial processes. It is thus aimed to provide an overview of PEBA MMMs. This review is especially devoted to summarizing the effects of nanoparticle loading on PEBA performance and properties such as selectivity, permeability, thermal and mechanical properties, and others. In addition, the preparation techniques of PEBA MMMs and solvent selection are discussed. This article also discusses the many types of nanoparticles incorporated into PEBA membranes. Furthermore, the future direction in PEBA MMMs research for separation processes is briefly predicted.
Estimation of the Y-chromosomal short tandem repeat (Y-STR) mutation rates in Turkey
Authors: Mertoglu Elif , Filoglu Gonul , Zorlu Tolga , Bulbul Ozlem 
Published: February 2018

Abstract

Background
The Non-recombining region of the Y-chromosome (NRY) is transferred from father to son in an unchanged form without recombination in meiosis. Since Short tandem repeats on Y-chromosome (Y-STRs) in this region do not have any recombination, these regions are identical in all male individuals who are related to the father except for mutations. Therefore, these regions gain importance in identification for the forensic sciences or determination of paternity. In determination of paternity, if mismatches are observed between father and child, population-specific mutation rates should be used to determine whether it is a mutation or a true exclusion. Therefore in this study, we aim to determine the mutation rates of 17 Y-STR loci in Turkey.

Material and methods
17 Y-STR loci were typed by using AmpFlSTR® Yfiler™ Kit in 90 volunteer father-son pairs. Mutation rates were calculated and compared with other populations.

Results
The mutations were found between three father-son pairs at DYS439 and DYS458 loci. In addition, a duplication in DYS389 II loci* 30, 31 was observed. The average mutation rate was determined as 1.96×10−3 for Turkish population.

Conclusion
This investigation will contribute to minimize the possibility of false exclusion of the father-son and kinship relations.
Seguridad Alimentaria: Evolución conceptual y relación con el cambio climático
Authors: Rodríguez Quirós Rigoberto 
Published: February 2018

El cambio climático en la actualidad es un reto para el ser humano, sus efectos se dan en todos los aspectos de la vida: la biodiversidad (flora y fauna), la disposición de agua para consumo humano, industria y sector agropecuario, alteración de los sistemas productivos, y la seguridad alimentaria; conocer el origen y evolución de este último concepto es fundamental para establecer su relación con el cambio climático y plantear los desafíos que se enfrentan.Estos desafíos deben ser atendidos por todos los sectores: tomadores de decisión, institucional, académico y sociedad civil, con el fin de poder abordarlo de la manera más adecuada y proveer soluciones. En este apartado se pretende abordar dos cuestiones básicas: cuál ha sido el origen y la evolución teórico-conceptual del concepto de seguridad alimentaria y cuáles son los principales retos que se tienen en la relación seguridad alimentaria – cambio climático.
The Narrow Road to Exoneration - the Incidence, Characteristics and Outcomes of Wrongful Conviction Claims in Sweden over a One-Year Period
Authors: Hellqvist Sara 
Published: February 2018

One way of investigating the phenomenon of wrongful convictions is to study the road to exoneration. In some respects, the post-conviction review process lies at the heart of the wrongful conviction issue, since this is where alleged miscarriages of justice are either acknowledged or rejected. However, the number and characteristics of the criminal cases that pass through the Swedish post-conviction review process are unknown. Against this background, the overarching objective of the present article is to provide an empirical basis for an informed discussion of wrongful convictions. More specifically, this article examines wrongful conviction claims and the judicial outcomes of these claims over a one-year period. The findings are discussed in relation to the view that the operation of the post-conviction process may be understood as a means by which the legal system may preserve its legitimacy. It is also discussed why there is a need for more transparency in this particular part of the criminal justice system.
Editorial V.15 N.2
Authors: REB Equipe Editorial 
Published: February 2018

A entrega do 1o Prêmio Nacional de Ensino de Bioquímica e Biologia Molecular Bayardo Baptista Torres foi realizada na seção de encerramento da 46a Reunião anual da SBBq (27-30 de julho), na cidade de Águas de Lindóia/SP. Nessa oportunidade, aproveitamos para incrementar a divulgação da Revista de Ensino de Bioquímica (REB) em seu estande no evento usando painéis e folders explicativos.No decorrer do segundo semestre tivemos algumas mudanças no corpo editorial da revista. O Prof. Dr. André Amaral Gonçalves Bianco (Unifesp) tornou-se Co-editor da REB, o Prof. Dr. Bayardo Baptista Torres passou a ocupar a posição de Editor-Sênior e o prof. Gabriel Gerber Hornink assumiu as atividade de Editor-Chefe.A equipe de editores manteve seu trabalho de divulgação e ampliação da revista, buscando intensificar sua internacionalização e o que já é observado, no número atual, pois contamos com três artigos publicados em língua inglesa, sendo que um deles é de autoria de pesquisadores da Índia.Em 2017, contabilizamos 44.935 acessos realizados ao site de nossa revista, por 33.154 usuários, de 120 países, totalizando cerca 111.270 visualizações de páginas.Na seção “Pesquisa em Ensino” há duas pesquisas focadas no ensino de Bioquímica envolvendo aspectos metabólicos: o primeiro aborda um estudo comparativo entre instrumentos didáticos para o ensino do ciclo da ureia e o segundo apresenta estudos dirigidos diferenciados objetivando a aprendizagem significativa dos alunos.A seção “Inovações Educacionais” apresenta duas práticas interessantes: uma experiência da iniciação científica em neurofisiologia por jovens do ensino médio e a contextualização de conceitos da estrutura de proteínas por meio de modelos do hormônio insulina.Na seção “REB na Escola” tivemos duas experiências no ensino médio; uma abordando o uso de modelos de moléculas para o ensino-aprendizagem de síntese de proteínas e outra envolvendo o ensino-aprendizagem de conteúdos de Biologia Celular por meio de práticas pedagógicas alternativas.Esperamos que os trabalhos publicados na REB possam contribuir para as pesquisas na área da Bioquímica, Biologia Molecular e áreas correlatas, como Fisiologia, Genética, Biologia celular, e convidamos professores e estudantes a enviarem e compartilharem suas descobertas e inovações.AtenciosamenteBayardo B. Torres - USPEditor-sêniorGabriel G. Hornink - Unifal-MGEditor-chefeVera Maria T. Trindade - UFRGSCo-editorEduardo Galembeck - UnicampCo-editorAndré Amaral Branco - UnifespCo-editor
Is there a Title Role for Renal Sympathetic Denervation in Patients with Symptomatic Myocardial Bridging Refractory to Clinical Treatment and Ventricular Arrhythmias?
Authors: Kiuchi Marcio Galindo , Chen Shaojie 
Published: February 2018

The connection concerning the autonomic nervous system and coronary spasm during the systole is multifaceted. An augmentation in sympathetic activity, due to pain caused by angina and the several transient ischemic episodes may origin an augment in noradrenaline, the neurotransmitter of efferent sympathetic fibers, triggering more vasoconstriction by stimulating vascular smooth muscle cells, besides may lead the cardiac hypertrophy. Based on these concepts we aim to find a role to renal sympathetic denervation in patients with symptomatic myocardial bridging refractory to standard clinical treatment and ventricular arrhythmias. In conclusion, our findings suggest that RSD can be a role in myocardial bridging treatment, augmenting the LVEF, diminishing the LV mass and the number of transient ischemic segments measured by CMRI, besides to reduce the number of individuals presenting symptoms, the mean of NSVT recorded by 24-hour-Holter monitoring, and the number of patients with SVT inducible by the EPS. Perhaps such benefits are due to the decrease in the LV mass and sympathetic cardiac activity, consequently, there being less constriction of the arteries with myocardial bridges and less ventricular arrhythmias.We report preliminary data on 6 patients with controlled hypertension, with normal renal function, with symptomatic myocardial bridging refractory to clinical treatment and ventricular arrhythmias who underwent a pilot renal sympathetic denervation (RSD) procedure. At baseline, the 6 (100%) patients presented symptoms while 6 months after RSD only 1 (17%) subject still complained of the symptoms (P=0.0152). Our findings suggest that RSD can play a role in myocardial bridging treatment, augmenting LVEF, diminishing LV mass and the number of transient ischemic segments measured by CMRI.
A Research on Reasons for Participation of Producers to Agricultural Fairs
Authors: SAVRAN Ferhan , KÖKSAL Özdal , AKTÜRK Duygu 
Published: February 2018

Agricultural fairs, giving a chance to farmers and agricultural suppliers to get
together in a certain time and place, allowing direct and efficient information
exchange, face-to-face interaction, are significant promotional activities. In
Turkey like developing countries, agricultural fairs have a great significance
in introduction of new technologies in agriculture. In Turkey, totally 456
fairs were organized in 2015 and 49 of them were related with agriculture and
green houses. In this study, individual and enterprise characteristics of the
producer visiting the “Field Day” fair held in Tekirdağ-Turkey in 2015,
benefits and gains provided to producers, producer perspectives on fairs were
assessed. The questionnaires made with 173 producers visiting the fair
constituted the primary material of the study. Data were analyzed with
Non-Linear Canonical Correlation Analysis (DOKKA). It was observed that the
producers with high-level education visited more number of fairs and this
producer group consider agricultural fairs as an effective tool in introducing
agricultural innovations. In general, producers visited agricultural fairs to
see new technologies, to gain a prestige and to reach economically available
technologies.&nbsp;&nbsp;
Menemen Ekolojik Koşullarında Borago officinalis L. (Hodan) Bitkisinde Farklı Sıra Arası Mesafelerinin Bazı Verim ve Kalite Özelliklerine Etkileri
Authors: Sönmez Çiğdem , Şimşek Soysal Ayşe Özge , Taghiloofar Amir Hasan , Bayram Emine , Çoşkunol Hakan 
Published: February 2018

Bu çalışma E.Ü. Ziraat
Fakültesi Menemen Araştırma ve Üretim Çiftliğinde organik üretim alanında
2014-2015 ve 2015-2016 yıllarında gerçekleştirilmiştir. İki yıl süreyle
yürütülen bu araştırmada Borago
officinalis L. bitkisinin bazı verim ve kalite özellikleri üzerine farklı
sıra arası mesafelerinin (30 cm, 40 cm, 50 cm ve 60 cm) etkileri
araştırılmıştır. İlk ve ikinci deneme yıllarında sırasıyla bitki boyu
58.16-77.0 cm, 65.86-75.93 cm; 1000 tane ağırlığı 16.3-17.0 g, 15.0-16.4 g; dal
sayısı 5.96-7.46 adet/bitki, 6.55-8.10 adet/bitki; salkım sayısı 27.40-41.86
adet/bitki, 31.50-33.85 adet/bitki; tane verimi 44.38-76.39 kg/da, 41.67-79.72
kg/da arasında değişmiştir. Her iki deneme yılında da sıra arası mesafeleri
arttıkça 1000 tane ağırlığı dışındaki değerlerin artış gösterdiği
belirlenmiştir. Araştırmada sabit yağ oranları ilk yıl %29.96-34.04, ikinci yıl
%30.13-33.67 aralığında değişmiştir. Sıra arası mesafeleri arttıkça sabit yağ
oranlarında bir azalma gözlenmiştir. Yağ bileşimleri incelendiğinde, yıllar ortalaması
olarak palmitik asit %13.10-13.31, stearik asit %3.78-4.07, oleik asit %20.26-20.74,
linoleik asit %36.40-37.54, ϒ-
linolenik asit %18.20-18.71,
eikosenoik asit %4.09-4.25 ve erüsik asit %2.36-2.60 olarak saptanmıştır.
Sonuçta Borago officinalis bitkisinde
kabul edilebilir tane verimi ile birlikte yüksek düzeyde yağ içeriği elde
edilebilmesi bakımından 50 cm sıra arası mesafesinin uygulanması gerektiğini
söylemek mümkündür.&nbsp;