bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Molecular Mechanisms of Human Osteosarcoma Cell Apoptosis Induced by Arsenic Trioxide and Vincristine
Authors: Yao Xiao-Guang , Zhang Wei-Hua , Zhao Gui-Song , Yao Jia-Chen , Wu Peng-Huan , Song Shu-Xia , Liu Su-Yuan , Arun Sigdel 
Published: September 2019

Background: Arsenic trioxide (As2O3) and vincristine (VCR) have been used for the treatment of tumors. But little is known about the mechanisms and whether they induce apoptosis of human osteosarcoma MG-63 cells.
Methods: MG-63 cells were treated with As2O3 and VCR, respectively. Their effects on cell apoptosis and cell cycle arrest were evaluated by MTT assay and flow cytometry. Their effects on the expressions of apoptosis-related proteins PCNA, Bcl-2, Bax, caspase-3, cyclin D1 and cyclin E were investigated by Western-blot.
Results: Both As2O3 and VCR have time- and dose-dependent effects on apoptosis and cell arrest of MG-63 cells. As2O3 induces MG-63 cell arrest in S phase, whereas VCR induces MG-63 cell arrest in G2/M phase. Both As2O3 and VCR suppress the expression of PCNA, cyclin D1, cyclin E and Bcl-2, and increase the expression of Bax and casepase-3.
Salvage robot-assisted radical prostatectomy (sRARP) for radiation resistant prostate cancer in a group of initially high risk patients
Authors: Lamichhane Nirmal , Dowrick Adam S. , Axcrona Ulrika , Brennhovd Bjørn , Fosså Sophie D. , Axcrona Karol 
Published: September 2019

Introduction: Salvage robot-assisted radical prostatectomy (sRARP) is seen as an attractive option for salvage treatment of radiation therapy -recurrent prostate cancer (PC), thanks in part to the good visualisation that is possible using this modality. However, the results of fewer than 200 salvage sRARPs have been published in the literature. We report the outcomes in a cohort of initially high risk patients of robot-assisted radical prostatectomy as salvage local therapy for radiation-resistant PC in a Scandinavian healthcare setting.
Materials and methods: A retrospective review of the charts of all patients who underwent sRARP for biochemical failure (BCF) after primary radiation treatment for localised PC at a single institution was performed.
Results: Twenty-two patients, median age 67 years (range 57 to 72), had sRARP performed between June 2008 to July 2013. A median follow-up of 26 months (range 2 to 63) was observed. Perioperative complications occurred in 4 patients (18%), with one patient sustaining a rectal injury. Histo-pathological diagnosis was pT2 in three, pT3a in five, pT3b in twelve and pTx in one patient. Ten patients (45%) had a positive surgical margin (PSM). At follow-up, 54 % of patients were free of biochemical progression and 41% were continent.
Conclusions: We showed that salvage RARP is technically feasible in a cohourt of patients with predominantly high risk disease. This study adds to the limited data already in the literature, demonstrating the high frequency of locally advanced (pT3b) PC, a patient group that is usually not included in salvage treatments, as e.g. high frequency ultrasound or salvage brachytherapy. Further, given that the historical barriers to salvage RP with higher rates of rectal injury and poor urinary control no longer seem to be applicable in the modern era, we think that more patients should be considered candidates for this potentially curative salvage treatment of radiation-resistant PC. However, long-term follow-up is needed to confirm if the additional burden on these patients confers to oncological control following the procedure.
Intubating Conditions with three different doses of Rocuronium in surgery of cancer patients
Authors: Wagle Bhawana , Regmi Yogesh 
Published: September 2019

Background: This is a prospective randomized, double blind study to determine the doses of rocuronium that would give 90% and 95% probabilities of successful tracheal intubation within 60s after administration. This study evaluated intubating conditions and duration of action of 0.4 mg, 0.8 mg and 1.2 mg of rocuronium, administered intravenously in patients undergoing elective surgical procedures. Goal in this study is to define doses level of rocuronium that would provide optimal relaxation for tracheal intubation in patients in whom succinylcholine was relatively contraindicated.
Methods: Sixty patients both male and female, ASA I & II, age between 18–60 years, with BMI of less that 30 who were planned for elective surgical procedures were randomized into three groups. Group A received 0.4 mg (n=20), Group B received 0.8 mg (n=20) and Group C received 1.2 mg (n=20) of rocuronium. At 60 seconds after injection of the rocuronium, laryngoscopy was initiated, with the goal being endotracheal tube passed through the patient's vocal cords and the cuff inflated within the trachea in 20s. Intubating conditions was graded excellent, good or poor according to Cooper scoring system criteria. When the patient lost consciousness, train-of-four (TOF) stimulation (at 2 Hz and repeated every 12s) were recorded. Immediately after tracheal intubation and every 5 min thereafter the investigator counted the number of tactile TOF responses. The duration of action of rocuronium was defined as the time from the end of injection of rocuronium until reappearance of first tactile response to TOF stimulation.
Results: There were twelve patients in the 0.4mg/kg rocuronium group, two in the 0.8mg/kg group, and one in the 1.2mg/kg rocuronium group with an unacceptable intubation grade caused by sustained coughing at intubation. The D90 and D95 doses were 0.83(0.59 -1.03) and 1.04 (0.76-1.36) mg/kg, respectively. Estimated time until first tactile train-of-four response after D50 and D95 doses were 43min and 52 min, respectively.
Conclusion: After induction with pethedine and sodium thiopentone, rocuronium in a dose of 0.8mg/kg produces equivalent intubating conditions as that of 1.2mg/kg after 60 seconds of administration
Community Screening of Prostate Cancer in Eastern Nepal
Authors: Belbase Narayan , Agrawal C.S. 
Published: September 2019

Background: Prostate cancer incurs a substantial incidence and mortality burden, and it ranks among the top ten specific causes of death in males.
Objectives: To explore the situation of prostate cancer in a cohort of healthy population in Eastern Nepal.
Methods: This study was conducted in the Department of General surgery at B. P. Koirala Institute of Health Sciences, Dharan, Nepal in the department of surgery from July 2010 to June 2011. Males above 50 years visiting Surgical Outpatient Department in BPKIHS were enrolled in the study. Screening camps were organized in four Teaching district hospitals of BPKIHS in Eastern Nepal. Digital rectal examination (DRE) was done by the trained professionals after collecting blood for serum prostatic specific antigen (PSA). Trucut biopsy was done for all individuals with abnormal PSA, DRE or both findings.
Results: A total of 1521 males more than 50 years of age were assessed and screened after meeting inclusion criteria. Maximum individuals 1452 (96.2% ) had PSA ≤ 4.0 ng/ml. Abnormal PSA ( > 4 ng/ml) was found in 58 (3.8%) individuals. Abnormal DRE was found in 26 (1.72%) individuals. Both DRE and PSA was abnormal in 26 (1.72%) individuals. On the basis of raised PSA or abnormal DRE 58 (3.84%) individuals were subjected to digitally guided trucut biopsy. Biopsy report revealed Benign Prostatic Hyperplasia in 47 (3.11%) individuals and adenocarcinoma prostate in 11 (0.73%) individuals. The specificity of DRE was 65.95% sensitivity 90.9% and positive predictive value 38.46%. The sensitivity of PSA more than 4ng/ml in detecting carcinoma prostate was 100% and the positive predictive value for serum PSA was 18.96%.
Conclusion: The overall cancer detection rate in this study was 0.73% and those detected were locally advanced. Larger community-based studies are highly warranted specially among high-risk groups.
Video endoscopic inguinal lymphadenectomy and open inguinal lymphadenectomy for penile cancer in China: a systematic review
Authors: Du Jiang-Ping , Lamichhane Nirmal 
Published: September 2019

Background: To evaluate the effect between video endoscopic inguinal lymphadenectomy (VEIL) and open inguinal lymphadenectomy (OIL) for penile cancer to provide the evidence-based basis for the selection of the clinical therapy schemes.
Methods: The related clinical controlled trial literatures on the effective comparison of VEIL and OIL were retrieved from the databases of CNKI and Wanfang database. The screening was independently performed by reviewer according to the including and excluding criteria. The related data were extracted and the meta-analysis performed by the RevMan 5.3 software.
Results: A total of 9 trials were included. There were 335 cases of inguinal lymphadenectomies, in which 151 cases were VEIL and 184 cases were OIL. The meta-analysis results showed that there were no statistical differences between the two types of operations in terms of the operative time (WMD=28.74, 95% CI-4.12~61.60, P=0.09), but the difference between VEIL and OIL in term of intra-operative blood loss (WMD=-29.24, 95% CI–55.24~- 22.89, P<0.01), postoperative hospital stays (WMD=-3.43, 95%CI–5.07~-1.80, P<0.01), postoperative drainage time (WMD=-3.81, 95%CI–5.38~-2.23, P<0.01), surgical complications (Number of sides OR=0.53, 95% CI0.34~0.81, P<0.01; Number of cases OR=0.36, 95% CI0.24~0.54, P<0.01).
Conclusion: VEIL has approximately the same time of operation to OIL, but has less intra-operative blood loss, hospital stay, postoperative drainage time and surgical complications.
3D-printed moulds facilitate making an anatomically matched cement spacer for reconstruction long bone defection after resection of tumors of humerous
Authors: Zhao Haltao , Sigdel Arun , Hou Xizhi , Zhang Ting , Zhang Guochuan , Sun Tao 
Published: September 2019

Background: A nail and cement spacer is one of the option for the reconstruction of the proximal humerus after tumor resection among prosthesis unaffordable patients. However, making the cement spacer anatomically match its replacement remains challenging.
Presentation of case: A 12-year-old boy was diagnosed with osteosarcoma in the right proximal humerus by core needle biopsy. After preoperative neo-adjuvant chemotherapy, a wide resection was performed, and the defect was reconstructed with an anatomically matched cement spacer. The cement spacer was fabricated using 3D-printed moulds, which were made according to the mirror image of the left humerus based on CT data. The post-operative course was uneventful, and at the 12-month follow-up, the patient is able to move with only some restriction in abduction and upward lift. The MSTD score was 21.
Conclusion: Fabrication of an anatomically matched cement spacer using 3D-printed moulds is a simple, inexpensive, and reproducible procedure for reconstruction complex bone defect.
Leukaemia with pregnancy managed at B. P. Koirala Memorial Cancer Hospital
Authors: Pariyar J , Shrestha B , Acharya BC , Sharma KS , Shrestha J , Shrestha S , Sundas S , Panthee S 
Published: September 2019

Abstract: Leukaemia during pregnancy is rare, occurring approximately one in every 75,000 to 100,000 pregnancies annually. Chemotherapeutic agents may have harmful effects to the developing baby though leukaemia itself rarely harms the baby. There is no evidence that pregnancy accelerates the progression of disease or affects the outcome. However, treatment dilemmas often occur.
Aims: To study the clinical presentation, treatment and outcome of leukaemia with pregnancy managed at B. P. Koirala Memorial Cancer Hospital (BPKMCH).
Methods: Descriptive study was conducted at BPKMCH. Case records of women with cancer and pregnancy from January 2006 to February 2013 were analyzed regarding their clinical details, treatment, follow-up and feto-maternal outcome.
Results: Six women, of 20 to 28 years had leukaemia with pregnancy among which four were chronic myeloid leukaemia (CML), one was acute lymphocytic leukaemia (ALL) and acute myeloid leukaemia (AML) each. All four cases of CML had conceived while on oral Imatinib; the three case diagnosed in the first trimester opted for immediate termination of pregnancy while the fourth one diagnosed at 22 weeks of pregnancy continued pregnancy and delivered at 34 weeks by emergency caesarean section for severe oligohydramnios. The ALL case diagnosed at 26 weeks of pregnancy wanted termination of pregnancy and immediate induction chemotherapy. The AML case diagnosed at 32 weeks of pregnancy desired to undergo induction chemotherapy with pregnancy but she defaulted treatment and had intrauterine fetal death and died due to postpartum haemorrhage. The baby, delivered to a mother exposed to Imatinib throughout pregnancy, till date has normal growth and development. Five mothers are in remission.
Conclusions: Leukaemia with pregnancy, more common in younger women is rare and posed treatment challenges. Definitive treatment should be individualized according to the desire of the pregnant woman and should include a multi- disciplinary team. Termination of pregnancy in favour of definitive chemotherapy to mother is better and easier during the first trimester of pregnancy. Because of teratogenic effects of chemotherapy, effective contraception be used during therapy to prevent pregnancy.
Peningkatan Phycocyanin pada Spirulina Platensis dengan Media Limbah Virgin Coconut Oil pada Photobioreactor Tertutup
Authors: Sukadarti Sri , Wahyu Murni Sri , Azimatun Nur M.M. 
Published: September 2019

Waste of Virgin Coconut Oil (VCO) industries has a high value of Chemical Oxygen Demand (COD), it is therefore a problem for the environment. This waste contains organic materials such as oil, proteins, carbohydrates and some minerals, that potentially to be used for the cultivation of blue-green algae Spirulina plantesis. Spirulina plantesis is an excellent source of phycocyanin. The Phycocyanin has anti-aging, anti-oxidant and anti-inflammatory properties, it is therefore considered useful. This research is aimed to study the effects of the addition of urea and light intensity on the growth of Spirulina, the concentration of phycocyanin and decreasing of COD value. Spirulina platensis was cultivated in a closed photobioreactor with an air flow for 7 days. The light intensity was varied as follows 5000 lux, 6000 lux, 7000 lux and 8000 lux, and the addition of urea as nutrients was also varied as follows 40 ppm, 50 ppm, 60 ppm and 70 ppm. This research indicated that the optimum condition was obtained at the addition of urea of 70 ppm, light intensity of 6000 lux. This research resulted μmax of 1,1375day-1 , the biomass productivity of 0,0423 g/l/day, biomass concentration of 0,1734 g/l and phycocyanin concentration of 5,047%. The largest of COD removal is was 98,06% and the COD value of 280 mg/l was finally achieved.
PENGARUH TINGKAT KEASAMAN PADA KARAKTERISTIK ZEOLIT ALAM SEBAGAI ADSORBEN AMMONIUM HIDROKSIDA (NH4OH)
Authors: Fajar Mukti Nur Indah 
Published: September 2019

Natural zeolite is a mineral that are widely available in Indonesia. Among many other benefits, the natural zeolite can be used as an adsorbent to reduce water pollutant caused by ammonia compounds and combination of derivatives. This research aimed to study the effect of different acids on zeolite characterizatics as adsorbent of ammonium hydroxide (NH4OH). The effect of acids addition on natural zeolite was studied by varying the concentration of H2SO4(0,5 N; 3 N and 5 N) and concentration of H3PO4 (0,5 N; 3 N and 5 N). In this study, zeolite surface was observed by Fourier Transform Infrared (FTIR). Results were showed that the amount of NH4OH adsorbed on H- zeolite has a maximum (23,6 mg/gram zeolit) at 5 N H2SO4. From the NH4OH uptake experiment, it was noted that zeolite obtained from H-Zeolite-H2SO4 has higher NH4OH adsorption capacity than that of zeolite obtained from H-Zeolite-H3PO4. The adsorption capacity of H-Zeolite-H2SO4, H-Zeolite-H3PO4, are 23,6 mg/g and 12,9 mg/g, respectively. FTIR analysis was showed that NH4OH adsorbed on the surface of H- zeolite on Brønsted acid peak.
HUBUNGAN PARITAS DENGAN DERAJAT LASERASI JALAN LAHIR DI POLINDES JETIS LOR KECAMATAN NAWANGAN KABUPATEN PACITAN
Authors: Yogi Etika Desi 
Published: September 2019

For women, the perineum is very important stretching and lubricating the perineum during labor can weaken the pelvic floor muscles in the vaginal wall, trauma to the perineum also causes discomfort and pain during sexual intercourse and an estimated 85% of maternal mothers experience birth canal lacerations (Kettle and Tohil 2008). One of the fears that are often felt by pregnant women, especially third timers, is fear of being torn and afraid of sewing. Especially for mothers who have experienced it, this can make their own trauma when facing the birth process later (USU, 2006). The purpose of this study was to determine the relationship of parity to the degree of laceration of the birth pathway in Jetis Lor Polindes, Nawangan District, Pacitan Regency.
The design or design in this study is correlation analysis, with the "retrospective" approach. This study analyzed the relationship of parity with the degree of laceration of the birth path in Jetis Lor Polindes, Nawangan District, Pacitan Regency. In this study, the population was all mothers giving birth at Jetis Lor Polindes, Nawangan District, Pacitan Regency. The samples in this study were all mothers giving birth at Jetis Lor Polindes, Nawangan District, Pacitan Regency. In this study by looking at the last 1 year data. In this study the independent variable is parity. In this study the dependent variable is the degree of laceration of the birth canal. Based on the calculation results of SPSS 11.5 for Windows, it was found that there was no relationship between parity and laceration degrees in the Jetis Lor Polindes, Nawangan Subdistrict, Pacitan Regency, from the results of probability (sig. 2-tailed) 0.22 <0.05.The researcher hopes that the mother will seek information and increase knowledge about the labor process, so that with good knowledge will reduce lacerations on the birth canal
Efek Aditif SiO2 Terhadap Suhu Sintering Keramik Alumina dan Karakteristiknya
Authors: Djuhana Djuhana , Mulyadi Mulyadi , Sunardi Sunardi 
Published: September 2019

Sintering keramik alumina dilakukan dengan aditif SiO2 dari pasir silika. Komposisi silika divariasikan yaitu 0 %, 5 % dan 10 % berat. Kedua bahan baku ditimbang, di campur menggunakan media aquades dan digiling menggunakan rotary ball mill selama 10 jam. Selanjutnya capuran tersebut di keringkan untuk menguapkan aquades menggunakan pengering pada suhu 100oC selama 12 jam. Kemudian campuran serbuk tersebut diukur distribusi ukuran partikel menggunakan Laser Particle Size. Selanjutnya serbuk tersebut dicampur dengan perekat PVB sebanyak 2% berat dan dilanjutkan dicetak dengan gaya 10 tonf untuk membentuk pellet. Kemudian pelet tersebut disintering menggunakan Thermolyn Furnace pada suhu 1200, 1300, 1400 dan 1500oC dengan waktu penahanan 2 jam dan heating rate 10oC/menit. Hasil pengukuran particle size menunjukkan bahwa serbuk setelah di milling memiliki ukuran diameter rata-rata adalah 18,48 µm. Hasil dari karakterisasi diperoleh kondisi yang optimum yaitu sampel dengan penambahan 10 % SiO2 dan suhu sintering 1500oC memiliki bulk densitas tertinggi 3,36 g/cm3 dan porositas 1,06 %, hardness vickers tertinggi = 780 Hv. Penambahan SiO2 sampai 10 % berat tidak menimbulkan rekasi dengan Al2O3, terlihat tida ada pembentukan fasa baru dari hasil XRD, dan fasa yang terbentuk adalah fasa corundum (α-Al2O3).
Special Features of the Crime’s Subject Under the Article 330 of the Criminal Code of Ukraine
Authors: Boichuk V. Yu. 
Published: September 2019

On the basis of the analysis of criminal and legal literature, certain provisions of the Criminal Code of Ukraine and court practice of their application, the author has determined that the description of special features of the crime’s subject through the construction of “in connection with the performance of official duties” used by the legislator in the disposition of the Art. 330 of the Criminal Code of Ukraine indicates the identity of the subject to the category of officials. At the same time, taking into account the dualism of criminal and legal approaches to the definition of the term of “an official” in the descriptions of a victim and the crime’s subject, the author has emphasized on the application of the more narrow concept laid down in Part 3 of the Art. 18 of the Criminal Code of Ukraine and the Resolution of the Plenum of the Supreme Court of Ukraine dated from April 26, 2002 No. 5 “On judicial practice in cases of bribery”.
As a result, the author has come to the conclusion that a special subject of the crime under the Art. 330 of the Criminal Code of Ukraine may be officers of the departments of the National Police of Ukraine, the State Investigation Bureau, the Security Service of Ukraine, the Foreign Intelligence Service of Ukraine, the State Border Guard Service of Ukraine, the Office of State Security, the State Fiscal Service of Ukraine, the State Penal Service of Ukraine, the Ministry of Defense of Ukraine, the President of Ukraine, officials of the President’s Administration of Ukraine, Verkhovna Rada of Ukraine, Cabinet of Ministers of Ukraine, National Security and Defense Council of Ukraine, Supreme High Command General Headquarters of Ukraine, the Ministry of Defense of Ukraine, the General Staff of Armed Forces of Ukraine, the unions, military units and units of the Armed Forces of Ukraine, the State Special Transport Service, the State Service for Special Communications and Information Protection of Ukraine, the National Guard of Ukraine, the Council of Ministers of the Autonomous Republic of Crimea, regional, district, city and district in the cities, state administrations and local self-government agencies, as well as officials of enterprises, institutions and organizations that carry out state defense orders, conduct research and perform development in the defense area, etc.