bluuebunny/crossref_metadata_2025_split huggingface dataset:
Toxicity Profile of Double-agent Adjuvant Chemotherapy after Concurrent Chemoradiation and Brachytherapy in Locally Advanced Cervical Cancer: Comparison with Standard Chemoradiation Protocol
Authors: Pandya Tejas , Suhag Virender , Ranjan Subhash , Sunita BS , Pandya Sujata 
Published: July 2019

Abstract
Introduction: Carcinoma cervix is the most common gynecological malignancy in India and a major cause of cancer mortality and morbidity in the females despite Concurrent chemoradiotherapy (CCRT). Attempts are on to improved overall survival by addition of adjuvant chemotherapy (ACT) to CCRT. Aim: The aim of this study is to establish toxicity profile of double-agent ACT after CCRT and ICRT in locally advanced cervical cancer (LACC) and to compare it with standard chemoradiation protocol. Materials and Methods: Patients were randomized into two arms: in conventional arm (Arm 1, n = 23), patients received a standard protocol of weekly injection cisplatin 40 mg/m2 concurrently with pelvic external beam radiotherapy (5040cGy/28 fractions) followed by ICRT (03 fractions of 7 Gy each). In interventional arm (Arm 2, n = 24), patients received CCRT/ICRT protocol; and were further offered ACT with three cycles of consolidation chemotherapy using injection paclitaxel and injection carboplatin every 3 weeks after CCRT and ICRT. Results: The incidence of anemia was 14/23 (50% Grade 1) in Arm 1 and 12/24 in Arm 2 (17% Grade 1, rest higher grade). In Arm 2, 37% of patients had ≥Grade 2 neuropathy and 16% of patients had Grade 1 alopecia, whereas nil incidence was reported in Arm 1 (P = 0.005 and 0.04, respectively). Grade 3 neutropenia was observed in 4/23 (17%) patients of Arm 1 and 8/24 patients (33%) of Arm 2. None of the patients in Arm 1 required indoor supportive care while 4/24 patients (17%) were managed as an indoor patient. Among late toxicities, in Arm 2, the incidence of Grade 2 and Grade 3 anemia was 42%, whereas in Arm 1, its incidence was 22%. In Arm 1, no patient exhibited features of neuropathy, whereas, in Arm 2, 12/24 (50%) of the patients had neuropathy (P value for these two late events was <0.05 statistically significant). No therapy-induced mortality was noted. Conclusion: Exhibition of ACT with injection Paclitaxel and injection carboplatin in locally advanced carcinoma cervix is a technically viable option with manageable toxicity.
A Study of Hormone Receptor Status in Breast Carcinoma and use of HER2-Targeted Therapy in a Tertiary Care Center of India
Authors: Bhaskar Sandeep , Rastogi Kartick , Gupta Shivani , Jindal Arpita , Bhatnagar Aseem Rai , Jain Sandeep 
Published: July 2019

Abstract
Aims: The aim is to study the hormone receptor status, association of HER2 expression with prognostic factors and use of HER2-targeted therapy in North Indian breast cancer patients. Subjects and Methods: Immunohistochemistry reports of 288 breast cancer patients registered in the department of Radiotherapy, SMS Medical College, Jaipur in 2015–2016 were analyzed for estrogen receptor (ER), progesterone receptor (PR), and c-erb B-2 protein (HER2/neu) expression. Equivocal HER2 (2+) was further confirmed by fluorescent in situ hybridization (FISH). Number of patients receiving HER2/neu-targeted therapy was also studied. Results: For ER, positive status was more common (56%), whereas for PR and HER2/neu, negative status was more common (59% and 60% resp.). HER2 status was unknown for 25% patients. The percentage of equivocal HER2 (immunohistochemistry 2+) cases showing amplification on FISH was also high (56.7%). The percentage of eligible cases for targeted therapy actually receiving it was low (28%). The percentage of triple negative phenotype (ER-/PR-/HER2-) was high (29.8%). Triple-negative breast cancer phenotype was more common in young-aged premenopausal women but was not statistically significant. All HER2/neu + cases were infiltrating ductal carcinoma. HER2/neu expression was significantly higher with large tumor size (P = 0.001), high tumor grade (P < 0.001), advanced stage (P = 0.001), greater number of positive lymph nodes (P = 0.02), and ER/PR negativity (P < 0.001). Conclusions: Most of the breast cancer patients are ER and/or PR positive and HER2/neu negative. The percentage of triple-negative phenotype is higher. More than half of HER2/neu 2+ cases show amplification on FISH assay. The percentage of eligible patients actually receiving targeted therapy is low. HER2/neu protein expression is significantly higher with adverse features such as large tumor size, high grade, advanced stage, greater number of positive lymph nodes, and ER/PR negativity.
Unusual Renal and Colonic Mass: Description of a Rare Case
Authors: Khare Manika , Ahuja Arvind , Bhardwaj Minakshi , Khattar Nikhil 
Published: July 2019

AbstractSeminoma is a germ cell tumor which accounts for approximately 40% of all germ cell tumors. Testicular seminoma is usually localized to the testis, and in 25% of cases, lymph node metastasis is seen. However, rarely, it can metastasize to visceras. We report a rare case of metastatic seminoma in a 40-year-old male who presented with renal and intestinal mass 2 years after orchidectomy.
A Rare Case of Endobronchial Metastasis in a Case of Carcinoma Tongue
Authors: Bisht Niharika , Singh Sankalp , Mishra Prabha Shankar , Gupta Samir , Kapoor Amul 
Published: July 2019

AbstractCancer of the tongue and other parts of the oral cavity are a leading cause of death in the worldwide population. The common sites of metastasis from oral cavity cancers are lung and bone. Endobronchial metastasis of an extra-thoracic malignancy is a rare phenomenon and such metastases from a malignancy of the tongue are almost unheard of. We present a case of carcinoma oral cavity with subsite tongue that after radical therapy of local site had an unusual site of distant metastasis in the right main bronchus, along with metastases to the lung parenchyma and right third rib.
Solitary Duodenal Metastasis from Renal Cell Carcinoma with Metachronous Pancreatic Neuroendocrine Tumor: Review of Literature with a Case Discussion
Authors: Baghmar Saphalta , Shasthry S M , Singla Rajesh , Patidar Yashwant , Bihari Chhagan B , Sarin S K 
Published: July 2019

AbstractRenal cell cancinoma (RCC) is a unique malignancy with features of late recurrences, metastasis to any organ, and frequent association with second malignancy. It most commonly metastasizes to the lungs, bones, liver, renal fossa, and brain although metastases can occur anywhere. RCC metastatic to the duodenum is especially rare, with only few cases reported in the literature. Herein, we review literature of all the reported cases of solitary duodenal metastasis from RCC and cases of neuroendocrine tumor (NET) as synchronous/metachronous malignancy with RCC. Along with this, we have described a unique case of an 84-year-old man who had recurrence of RCC as solitary duodenal metastasis after 37 years of radical nephrectomy and metachronous pancreatic NET.
Squamous Cell Carcinoma Developing De Novo in an Untreated, Nonsun-Exposed Psoriatic Plaque
Authors: Tandon Sidharth , Sharma Prafulla Kumar , Zutso Kezhaleto , Singh Ajeet 
Published: July 2019

AbstractPsoriasis is a chronic inflammatory dermatosis, which causes hyperproliferation of skin. Patients afflicted with psoriasis are also at a risk of developing nonmelanoma skin cancers, with the risk of such a possibility being attributed to the administration of systemic immunosuppressive agents, phototherapy, and biological agents. We present a case of psoriasis with de novo development of squamous cell carcinoma, in a photoprotected site, with no history of administration of systemic immunosuppressive agents, phototherapy, or biological agents.
Inhalation Exposure to Dioxins Air Pollutant Generated by Dead Body Incineration at Buddhist Temple: Cancer Risk Estimation
Authors: Joob Beuy , Wiwanitkit Viroj 
Published: July 2019

Abstract
Background: Dioxin is accepted as an important toxic chemical that can induce carcinogenesis. The dioxin contamination in air is accepted as an important air pollutant. Apart from the industry, the dioxin in air can be generated by other little mentioned sources. Methods: Here, the authors assessed the cancer risk due to inhalation exposure to dioxins air pollutant generated by dead body incineration at Buddhist temple based on situation in Indochina. Indeed, there are many thousand Buddhist temples in Indochina and the dead body incineration is routinely done at the temple every day and the dioxin generated from this activity is little mentioned. Results: According to this study, the risk of cancer due to exposure to dioxins air pollutant generated by dead body incineration at Buddhist temple is high and should be the issue for proper public health management. Conclusion: Dioxins air pollutant generated by Dead bodyIncineration at Buddhist temple is an important cancer risk for both adult and children living in that area.
Primary Renal Leiomyosarcoma Arising from Renal Vein: A Case Report of Rare Entity with Review of Literature
Authors: Kundu Reetu , Chandra Mahesh , Punia Rajpal Singh , Aggarwal Purnima 
Published: July 2019

AbstractPrimary renal sarcomas are extremely rare neoplasms accounting for about 1% of all malignant renal neoplasms. Among all the sarcomas of kidney, leiomyosarcoma is the most common histotype. The histogenesis of these tumors is unclear, and presumably, they arise either from renal capsule or smooth muscle of renal vessels or renal pelvis. We report a case of a 65-year-old woman, who presented with intermittent abdominal pain for 1 year. The correct diagnosis was established only after the histopathological analysis of the resected specimen. The poor prognosis borne by these tumors mandates a thorough evaluation of all renal masses with unusual gross and histomorphology.
Pediatric Bone Sarcomas: Outcome of Multimodality Treatment in a Single Institution in South India over a Decade
Authors: Shanmugam Subbiah , Govindasamy Gopu , Hussain Syed Afroze , Fells S Prinith Siga 
Published: July 2019

Abstract
Context: Pediatric bone sarcoma is a rare entity with low incidence of around 2.5–6 per million population in India. Management of this condition is well standardized, and global survival data are available; however, there is a paucity of data in the Indian perspective. Aim of the Study: The aim of this study is to analyze various prognostic factors and survival outcome. The purpose of this study is to assess the role of surgery, multiagent chemotherapy, and radiation in the management of these tumors. Patients and Methods: Retrospective analysis of patients aged 18 and less, diagnosed as bone sarcomas and treated in our tertiary cancer center. All the patients received at least one form of therapy depending on stage and site of the primary lesion. Results: Twenty-one patients of Ewing sarcoma and 20 patients of osteosarcomas were eligible and were included in the study. In Ewing sarcoma, completing the full course of standard chemotherapy and radiotherapy to the local site was associated with improved survival. In osteosarcoma, limb salvage surgery (LSS) had a significant difference in overall survival compared to amputation. Induction chemotherapy was associated with better percentage of necrosis and showed improved survival. The percentage of necrosis correlated positively with survival which was statistically significant (P = 0.015). Conclusion: The median survival in both these bone sarcomas is inferior to global trends. Probable reasons for such discrepancy are lack of compliance to treatment protocols due to age factors and late presentation. Completion of multiagent chemotherapy in both the tumors add to better survival. Radiotherapy in Ewing sarcoma improves survival. In osteosarcoma, LSS is an oncologically safe alternative to amputation. The percentage of necrosis following chemotherapy in osteosarcoma is a reliable predictor of prognosis.
An Unusual Tumor of the Vagina
Authors: Archana Archana , Shamsunder Saritha , Yadav Amit , Malik Sunita 
Published: July 2019

AbstractA 28-year-old female came with complaints of swelling in the perineal area; examination revealed a nontender and fixed mass of approximately 4 cm × 3 cm on the right vulvovaginal junction extending into the vaginal wall. Wide excision of the mass was performed; histopathological examination revealed features suggestive of Merkel cell carcinoma of vagina.
Burkitt Leukemia in a 5-Year-Old Girl with Williams–Beuren Syndrome: Review of the Literature
Authors: Patiroglu Turkan , Ozcan Alper , Karakukcu Musa , Ozdemir Mehmet Akif , Unal Ekrem 
Published: July 2019

AbstractWilliams–Beuren syndrome (WBS) is a rare neurodevelopmental genetic disorder associated with microdeletion at the long arm of chromosome 7 (7q11.23). Few cases have been reported with WBS with hemato oncological malignancies. Herein, we report Burkitt leukemia in a 5 year old girl with WBS. We like to call attention to the management of this rare combination.
Post-transplant Epstein–Barr Virus-Related Lymphoproliferative Disorder: A Case Report and Review of Literature
Authors: Goli Vasu Babu , Shah Preet , Bhat M Ganapathi , Nagral Aabha 
Published: July 2019

AbstractPost transplant lympho-proliferative disorders (PTLD) are a serious complications of solid organ transplantation. Solid organ recipients have an increased risk of cancers related to immunosuppression and the Epstein-Barr virus (EBV)-in particular lymphomas and majority of PTLD are of B-cell origin. The occurrence of PTLD in solid organ recipients can have varied clinical presentation and histopathological features. Although lymphoproliferative disorders were initially reported to be rare complication of transplantation, observations in past decade shown that they are common and are associated with poor outcomes. We report the case of a patient with deceased donor liver transplantation for Budd-chiari syndrome, who presented, four years after liver transplantation, with an EBV-associated Burkitt lymphoma with gastrointestinal and extensive skeletal metastasis recovered completely after adjustment of immunosuppressive treatment and chemo-immunotherapy. Our suggestion is that patients with the risk factors like T-cell depleting agents or increasing immunosuppressive therapy must be closely monitored with quantitative EBV PCR. Improvements in immunosuppressive strategies for transplantation and advances in treatment resulted in improved outcomes and long term survival for patients with PTLD.
Conjunctival Mass as the Initial Presentation of Acute Lymphoblastic Leukemia in a Child
Authors: Meena Jagdish Prasad , Sharma Aakanksha , Gupta Aditya Kumar , Singh Anuj , Maharana Prafulla Kumar , Phulware Ravi Hari , Seth Rachna 
Published: July 2019

AbstractAcute lymphoblastic leukemia (ALL) is the most common childhood malignancy with excellent survival. ALL has varied presentations. Presentation of ALL as a conjunctival mass is very rare. We report a child who presented to us with redness of the left eye and was found to have conjunctival mass. On biopsy, this mass was later diagnosed as ALL. The bone marrow examination supported the diagnosis. Timely diagnosis and initiation of treatment are essential to salvage the vision and to improve survival in such cases.
Nasal Cavity Cancer with Distal Phalanx Metastasis: An Extremely Rare Case Report
Authors: Rastogi Kartick , Dadhich Prashant , Bhaskar Sandeep , Gupta Shivani 
Published: July 2019

AbstractCancers of nasal cavity are relatively uncommon; and osseous metastases distal to the elbow and knee joints are also very rare. We herein report the two rare occurrences of nasal cavity carcinoma and acrometastasis together in the same patient, which is the first such case report to the best of our knowledge. The features associated with acrometastasis in the present study are similar to what has been cited in the literature, such as male gender, older age, widespread metastasis, single bone metastasis, lytic lesion, third finger, distal phalanx, poor prognosis, and short survival; however, involvement of left hand and nasal cavity as the primary site of tumor were the exceptions.
An Alternate Method of Fabrication of an Obturator in a Patient Diagnosed with Melanotic Neuroectodermal Tumor of Infancy
Authors: Dholam Kanchan P , Singh Gurkaran Preet , Gurav Sandeep V , Shinde Arati A 
Published: July 2019

AbstractThe quality of treatment and rehabilitation for the pediatric head and neck cancer patient has greatly improved due to interdisciplinary management. Surgical resection of maxilla leads to functional impairment which can be adequately restored with an obturator. However, its fabrication can be challenging in a pediatric patient. A simple, practical, and time-saving procedural modification in the fabrication of obturator in a patient diagnosed with rare melanotic neuroectodermal tumor of infancy has been presented.
Langerhans Cell Histiocytosis in a 5-Year-Old Girl: A Case Report and Review of Literature
Authors: Rao Shruthi , Hegde Shruthi , Thilak PS Gopinath , Babu G Subhas , Ajila Vidya , Shetty Urvashi , Buch Sajad Ahmad 
Published: July 2019

AbstractLangerhans cell histiocytosis (LCH) is an uncommon hematological disorder affecting infants and young children. LCH is a rare disorder of the reticuloendothelial system associated with proliferation of Langerhans cells and mature eosinophils. LCH can involve any bone, but the most common are pelvis, ribs, skull, long bones, vertebra, and facial bones. In the skull, frontal and parietal bones are commonly involved followed by the jaws, where mandible is more commonly affected than the maxilla. In this article, we report a case of LCH in a 5-year-old child involving the mandible. Swelling of one side of the face and aggressive periosteal reaction led to the diagnosis of monostotic LCH. The manuscript also summarizes the results of a literature search in PubMed of reported cases of LCH over the past 10 years.
O oportunismo pré-eleitoral ao nível das despesas públicas compensa na busca pela reeleição nos municípios catarinenses no século XXI?
Authors: Lautenschlage Jonatan 
Published: July 2019

Da construção de estradas a aumentos dos salários dos funcionários públicos, passando por reduções nos impostos no período que antecede as eleições, as manipulações orçamentais em anos eleitorais são um fenómeno observado em diversas nações, estados e municípios em todo o mundo. Muitos políticos acreditam que ao aumentarem as despesas no ano das eleições e durante o mandato, conseguirão aumentar as suas chances de obter um novo mandato. Mas será que isso realmente ocorre em Santa Catarina? E será que em todos os municípios catarinenses esse fenômeno é igual? Ao estudar as eleições municipais catarinense entre 2005 e 2016, contatou-se que os eleitores de Santa Catarina premiam o comportamento oportunista de seus prefeitos, tanto nas despesas públicas, como nos investimentos. Constatou-se, também, que o oportunismo compensa nos municípios com maiores níveis de IDHM.
‘Legal Multi-parenthood’ in Context: Experiences of Parents in Light of the Dutch Proposed Family Law Reforms
Authors: Cammu Nola 
Published: July 2019

‘Legal Multi-parenthood’ in Context: Experiences of Parents in Light of the Dutch Proposed Family Law Reforms
In 2016 the Dutch Government Commission of Reassessment of Parenthood (GCRP) proposed a wide array of legal changes to Family Law, e.g. with regard to legal multi-parenthood and legal multiple parental responsibility. Although the commission researched these matters thoroughly in its quest towards proposing new directions in the field of Family Law, multi-parents themselves were not interviewed by the commission. Therefore, this article aims to explore a possible gap between the social experiences of parents and the recommendations of the GCRP. Data was drawn from in depth-interviews with a sample of 25 parents in plus-two-parent constellations living in Belgium and the Netherlands. For the most part the social experiences of parents aligned with the ways in which the GCRP plans to legally accommodate the former. However, my data tentatively suggests that other (legal) recommendations of the GCRP need to be explored more in depth.---In 2016 stelde de Nederlandse Staatscommissie Herijking ouderschap voor om een wettelijk kader te creëren voor meerouderschap en meeroudergezag. Ondanks de grondigheid van het gevoerde onderzoek ontbraken er gegevens omtrent de ervaringen van de meerouders zelf. Dit artikel levert een bijdrage in het vullen van deze leemte door inzage te geven in de (juridische) ervaringen van 25 ouders in meerouderschapsconstellaties in België en Nederland.
Simultaneous determination of trace levels of Cd(II) and Pb(II) in tap water samples by anodic stripping voltammetry with 2-mercaptobenzothiazole modified electrode
Authors: Phlay Sophy , Tapachai Weena Aemaeg , Daungthong Supunnee , Worarattananurak Puchong , Chooto Pipat 
Published: July 2019

Glassy carbon electrode (GCE) modified by 2-mercaptobenzothiazole (MBT), mesoporous silica (Meso) and bismuth was developed to determine Cd(II) and Pb(II) simultaneously by square wave anodic stripping voltammetry (SWASV). In-situ preparation was found to work best in optimum conditions of acetate buffer pH 6, accumulation potential of -1.1 V, deposition time of 300 s and scan rate of 200 mV/s. SW peaks revealed the linear range of 5-50 µg/L Cd(II) and 5-50 µg/L Pb(II). LOD and LOQ for Cd(II) and Pb(II) were determined as 0.56, 0.80, 1.87 and 2.66 µg/L, respectively. The interaction of metals with bismuth and MBT, as well as higher surface area due to mesoporous silica, support beneficial performance of the modified electrode. Insignificant interferences from other regularly present metal ions were found. With SRM1640 standard, the SWASV results are found comparable to those obtained by inductive coupled plasma optical emission spectrometry (ICP-OES). The method was used to analyze the metals in tap water by standard addition method with the satisfactory recovery of 100.7 % for Cd(II) and 100.8 % for Pb(II).