bluuebunny/crossref_metadata_2025_split huggingface dataset:
Autocrine Fibronectin Inhibits Breast Cancer Metastasis
Authors: Shinde Aparna , Libring Sarah , Alpsoy Aktan , Abdullah Ammara , Schaber James A. , Solorio Luis , Wendt Michael K. 
Published: June 2018

Abstract
Both epithelial–mesenchymal transition (EMT) and mesenchymal–epithelial transition (MET) are linked to metastasis via their ability to increase invasiveness and enhance tumor-initiating capacity. Growth factors, cytokines, and chemotherapies present in the tumor microenvironment (TME) are capable of inducing EMT, but the role of the extracellular matrix (ECM) in this process remains poorly understood. Here, a novel tessellated three-dimensional (3D) polymer scaffolding is used to produce a fibrillar fibronectin matrix that induces an EMT-like event that includes phosphorylation of STAT3 and requires expression of β1 integrin. Consistent with these findings, analysis of the METABRIC dataset strongly links high-level fibronectin (FN) expression to decreased patient survival. In contrast, in vitro analysis of the MCF-10A progression series indicated that intracellular FN expression was associated with nonmetastatic cells. Therefore, differential bioluminescent imaging was used to track the metastasis of isogenic epithelial and mesenchymal cells within heterogeneous tumors. Interestingly, mesenchymal tumor cells do not produce a FN matrix and cannot complete the metastatic process, even when grown within a tumor containing epithelial cells. However, mesenchymal tumor cells form FN-containing cellular fibrils capable of supporting the growth and migration of metastatic-competent tumor cells. Importantly, depletion of FN allows mesenchymal tumor cells to regain epithelial characteristics and initiate in vivo tumor growth within a metastatic microenvironment.
Implications: In contrast to the tumor-promoting functions of fibronectin within the ECM, these data suggest that autocrine fibronectin production inhibits the metastatic potential of mesenchymal tumor cells. Mol Cancer Res; 16(10); 1579–89. ©2018 AACR.
Clinical and Imaging Predictors of Recurrent Ischemic Stroke: A Systematic Review and Meta-Analysis
Authors: Kauw Frans , Takx Richard A.P. , de Jong Hugo W.A.M. , Velthuis Birgitta K. , Kappelle L. Jaap , Dankbaar Jan.W. 
Published: June 2018

<b><i>Background:</i></b> Predictors of recurrent ischemic stroke are less well known in patients with a recent ischemic stroke than in patients with transient ischemic attack (TIA). We identified clinical and radiological factors for predicting recurrent ischemic stroke in patients with recent ischemic stroke. <b><i>Methods:</i></b> A systematic search in PubMed, Embase, Cochrane Library, and CINAHL was performed with the terms “ischemic stroke,” “predictors/determinants,” and “recurrence.” Quality assessment of the articles was performed and the level of evidence was graded for the articles included for the meta-analysis. Pooled risk ratios (RR) and heterogeneity (<i>I</i><sup>2</sup>) were calculated using inverse variance random effects models. <b><i>Results:</i></b> Ten articles with high-quality results were identified for meta-analysis. Past medical history of stroke or TIA was a predictor of recurrent ischemic stroke (pooled RR 2.5, 95% CI 2.1–3.1). Small vessel strokes were associated with a lower risk of recurrence than large vessel strokes (pooled RR 0.3, 95% CI 0.1–0.7). Patients with stroke of an undetermined cause had a lower risk of recurrence than patients with large artery atherosclerosis (pooled RR 0.5, 95% CI 0.2–1.1). We found no studies using CT or ultrasound for the prediction of recurrent ischemic stroke. The following MRI findings were predictors of recurrent ischemic stroke: multiple lesions (pooled RR 1.7, 95% CI 1.5–2.0), multiple stage lesions (pooled RR 4.1, 95% CI 3.1–5.5), multiple territory lesions (pooled RR 2.9, 95% CI 2.0–4.2), chronic infarcts (pooled RR 1.5, 95% CI 1.2–1.9), and isolated cortical lesions (pooled RR 2.2, 95% CI 1.5–3.2). <b><i>Conclusions:</i></b> In patients with a recent ischemic stroke, a history of stroke or TIA and the subtype large artery atherosclerosis are associated with an increased risk of recurrent ischemic stroke. Predictors evaluated with MRI include multiple ischemic changes and isolated cortical lesions. Predictors of recurrent ischemic stroke concerning CT or ultrasound have not been published.
Inheriting and Buying a Homeland: The Land of Israel and the Patriarchs
Authors: Cordoni Constanza 
Published: June 2018

AbstractAfter 70CE, when Israel was no longer an independent nation in the land of Israel and their cultic center was no longer physically present there, the rabbis of the Palestinian and Babylonian diaspora reflect from different perspectives on the beginning of the story of the land, on what can be called the “homeland myth” of the patriarchal narratives of Scripture. In doing so, they create their own ancestral homeland myth. In this article, two sets of rabbinic texts are examined in order to illustrate how the rabbis refashioned the scriptural myth and produced two versions of a rabbinic ancestral homeland myth. The first group of texts are related to the promise of the land and its fulfilment, the second to the establishment of the first Jewish grave in the promised land.
Copyist B of the Erasmiana Manuscripts in Gouda Identified
Authors: Klein Jan Willem 
Published: June 2018

Abstract
In the past I have written about the two copyists of the Gouda Erasmiana manuscripts, indicated by P.S. Allen as Copyist A and Copyist B. The identity of Copyist A has been revealed earlier as Henricus Jacobi Leidensis, a monk in the Stein convent, who was active in the first quarter of the fifteenth century. Copyist B, however—who was active around 1590—remained unknown. Further research brought up a name, which I had encountered earlier, but which I did not relate with the Erasmiana manuscripts. It concerns a monk who lived in Stein, but moved to Amsterdam in 1560, long before Copyst B wrote the manuscripts. And died there. This leads to one conclusion: the parts of the Erasmiana manuscripts written by copyist B, did not originate from the monastery of Stein or from Gouda, but were compiled in Amsterdam.
‘Avec Permission tacite’. The Amsterdam Edition of Rousseau’s Émile (1762)
Authors: Janssen Frans A. 
Published: June 2018

Abstract
We are well informed on the early editions of Rousseau’s Émile by the exemplary bibliography of Jo-Ann McEachern published in 1989. Two editions were to appear simultaneously, one for the French market, to be published in Paris by Nicolas-Bonaventure Duchesne, and an Amsterdam edition to be published by Jean Néaulme, for distribution to the rest of Europe. The imprint of the Néaulme edition reads: ‘Selon la Copie de Paris. Avec Permission tacite pour le Libraire’. This contribution tries to explain these words.
Have We Reached the Limits of Predictability for Tropical Cyclone Track Forecasting?
Authors: Landsea Christopher W. , Cangialosi John P. 
Published: June 2018

AbstractThe tropical cyclone is the largest single-day-impact meteorological event in the United States and worldwide through its effects from storm surge, extreme winds, freshwater flooding, and embedded tornadoes. Fortunately, over the last three decades there have been incredible advances in forecast accuracy, especially for the track of the tropical cyclone’s center. Errors have been cut by two-thirds in just 25 years due to global modeling advances, data assimilation improvements, dramatic increases in observations primarily derived from satellite platforms, and use of ensemble forecast techniques. These four factors have allowed for highly accurate synoptic-scale atmospheric initial conditions and forecasts of the steering flow out through several days into the future. However, such improvements cannot continue indefinitely. It is well known in the atmospheric sciences that there exists an inherent “limit of predictability” because of errors at the smallest scales (microscale—meters and seconds) that eventually cascade up to the largest scales (synoptic scale—thousands of kilometers and several days). While there have been estimates of the limits of predictability for tropical cyclone track prediction in the past, our current capabilities have exceeded those somewhat pessimistic earlier outlooks. This essay discusses the current state of the art for tropical cyclone track prediction and reassesses whether reaching the “limit of predictability” is imminent. The ramifications of this eventual conclusion—whether in the short-term or still decades away—could be critical for all users of tropical cyclone track forecast information, including the emergency management community/governments, the media, the private sector, and the general public.
Mechanisms Setting the Strength of Orographic Rossby Waves across a Wide Range of Climates in a Moist Idealized GCM
Authors: Wills Robert C. J. , Schneider Tapio 
Published: June 2018

AbstractOrographic stationary Rossby waves are an important influence on the large-scale circulation of the atmosphere, especially in Northern Hemisphere winter. Changes in stationary waves with global warming have the potential to modify patterns of surface temperature and precipitation. This paper presents an analysis of the forcing of stationary waves by midlatitude orography across a wide range of climates in a moist idealized GCM, where latent heating and transient eddies are allowed to feed back on the stationary-eddy dynamics. The stationary-eddy amplitude depends to leading order on the surface winds impinging on the orography, resulting in different climate change responses for mountains at different latitudes. Latent heating is found to damp orographic stationary waves, whereas transient eddies are found to reinforce them. As the climate warms, the damping by latent heating becomes more effective while the reinforcement by transient eddies becomes less effective, leading to an overall reduction in orographic stationary wave amplitude. These effects overwhelm the influences of a reduced meridional temperature gradient and increased dry static stability, both of which increase the sensitivity of the free troposphere to orographic forcing. Together with a reduction in the midlatitude meridional temperature gradient, the weakening of orographic stationary waves leads to reduced zonal asymmetry of temperature and net precipitation in warm, moist climates. While circulation changes in this idealized model cannot be expected to agree quantitatively with changes in the real world, the key physical processes identified are broadly relevant.
Multidimensional Intergenerational Instrumental Support and Self-Rated Health Among Older Adults in Rural China: Trajectories and Correlated Change Over 11 Years
Authors: Mao Weiyu , Chi Iris , Wu Shinyi 
Published: June 2018

Objectives: This study investigated the dynamic relationship between multidimensional intergenerational instrumental support and health over time. This approach is of theoretical, methodological, and practical significance in gerontological research. Method: Data came from The Well-Being of Older People in Anhui Province in 2001, 2003, 2006, 2009, and 2012. Of the 1,636 participants at baseline, a working sample of 1,557 older adults was used. Trajectories and correlated change were estimated using parallel latent growth curve modeling with maximum likelihood estimation. Results: “Received household-chore help” decreased over time, whereas “received personal-care help” increased over time. “Provided household-chore help” and “provided personal-care help” increased and then decreased over time. Increasing receipt of “household-chore help” and “personal-care help” were associated with faster decline in health over time. Discussion Findings suggest distinctive patterns of changes for different dimensions of intergenerational instrumental support and their relationship with changes in perception of health over time in later life.
The Effects of Chronic Iron Overload in Rats with Acute Acetaminophen Overdose
Authors: Ackerman Zvi , Skarzinski Galina , Link Gabriela , Glazer Maya , Pappo Orit , Grozovski Maria 
Published: June 2018

Background and Aims: Rats are resistant to acetaminophen (APAP) hepatotoxicity. In this study, we evaluated whether by augmentation of the hepatic oxidative stress, through the induction of hepatic iron overload (IO), it will be feasible to overcome the resistance of rats to the toxic effects of APAP. Method: Rats with no or increased hepatic IO. Results: Providing iron by diet induced hepatocellular IO, while parenteral iron administration induced combined hepatocellular and sinusoidal cell IO. APAP administration to rats with no IO caused an increase in hepatic oxidative stress and a decrease in the hepatic antioxidative markers but no hepatic cell damage. APAP administration to rats with hepatocellular IO further amplified the hepatic oxidative stress but induced only hepatocyte feathery degeneration without any increase in serum aminotransaminases. APAP administration to rats with combined hepatocellular and sinusoidal cell IO caused an unexpected decrease in hepatic oxidative stress and increase in the hepatic antioxidative markers and no hepatic cell damage. No hepatic expression of activated c-jun-N-terminal kinase was detected in any of the rats. Conclusions: The hepatic distribution of iron may affect its oxidative/antioxidative milieu. Augmentation of hepatic oxidative stress did not increase the rats’ vulnerability to APAP.
Current understanding of meningeal and cerebral vascular function underlying migraine headache
Authors: Levy Dan , Labastida-Ramirez Alejandro , MaassenVanDenBrink Antoinette 
Published: June 2018

Background The exact mechanisms underlying the onset of a migraine attack are not completely understood. It is, however, now well accepted that the onset of the excruciating throbbing headache of migraine is mediated by the activation and increased mechanosensitivity (i.e. sensitization) of trigeminal nociceptive afferents that innervate the cranial meninges and their related large blood vessels. Objectives To provide a critical summary of current understanding of the role that the cranial meninges, their associated vasculature, and immune cells play in meningeal nociception and the ensuing migraine headache. Methods We discuss the anatomy of the cranial meninges, their associated vasculature, innervation and immune cell population. We then debate the meningeal neurogenic inflammation hypothesis of migraine and its putative contribution to migraine pain. Finally, we provide insights into potential sources of meningeal inflammation and nociception beyond neurogenic inflammation, and their potential contribution to migraine headache.
Early Adolescent Substance Use and Mental Health Problems and Service Utilisation in a School-based Sample
Authors: Brownlie Elizabeth , Beitchman Joseph H. , Chaim Gloria , Wolfe David A. , Rush Brian , Henderson Joanna 
Published: June 2018

Objective: This paper reports on substance use, mental health problems, and mental health service utilisation in an early adolescent school-based sample. Method: Participants were 1,360 grade 7 and 8 students from 4 regions of Ontario, Canada. Students completed an in-class survey on mental health and substance use. The sampling strategy and survey items on demographics, substance use, service utilisation, and distress were adapted from the Ontario Student Drug Use and Health Survey. Internalising and externalising mental health problems were assessed using the Global Assessment of Individual Needs – Short Screener. Distress was defined as fair or poor self-rated mental health. Results: Rates of internalising and/or externalising problems above the threshold exceeded 30%; yet, fewer than half had received mental health services in the past 12 mo. Substance use was associated with increased odds of internalising and externalising problems above the threshold and distress. Youth using cannabis had 10-times the odds of exceeding the threshold for internalising or externalising problems. The use of substances other than alcohol or cannabis was associated with increased odds of fair or poor self-rated mental health among grade 8 students. Of the youth who confirmed at least a substance use problem, most also reported mental health problems; this association was stronger among girls than boys. Conclusions: Early adolescent substance use was associated with concurrent self-reported mental health problems in a non-clinical sample. The low levels of service utilisation reported highlight the need for improved access to early identification and intervention to prevent the development of concurrent disorders.
Operating room nurses’ perception of professional values
Authors: Torabizadeh Camellia , Darari Fatemeh , Yektatalab Shahrzad 
Published: June 2018

Background and significance of research: Nurses’ awareness of professional values and how those values affect their behaviors is an integral part of nursing care. There is a large body of research on nursing professional values, however, a careful survey of the available literature did not yield any studies investigating the status of professional values in operating rooms. Objective: This study aims to investigate the perception of operating room nurses of university hospitals toward professional values. Research plan: In this cross-sectional study, data were collected using Schank and Weis’s Nurses Professional Values Scale–Revised. The collected data were analyzed in SPSS version 16. Participants and settings: The 513 participants of the study consisted of operating room nurses and nurse anesthetists from six university hospitals. Ethical considerations: This study has been approved by the ethics committee of the university. Findings: The mean total professional values score of the operating room staff was found to be 100.84 ± 15.685, which indicates that the participants had a positive perception toward observance of nursing professional values in practice. The results showed that the participants considered the domains of justice and activism as, respectively, the most and the least important. The operating room staff’s overall professional values scores were not found to correlate significantly with their ages, professional experience, university majors, or attendance at ethics workshops. However, a significant difference was found between the professional values scores of the female and male staff. The professional values scores of the operating room nurses and the nurse anesthetists were not significantly different (p value = 0.494). Conclusion: Operating room staff’s awareness of professional values is essential to providing care to patients based on professional principles. Accordingly, there is need for programs to raise operating room nurses’ awareness of their professional duties and improve their professional performance.
Connecting Personal Experiences of Loss and Professional Practices in Advance Care Planning and End-of-Life Care: A Survey of Providers
Authors: Wallace Cara L. , Cruz-Oliver Dulce M. , Ohs Jennifer E. , Hinyard Leslie 
Published: June 2018

Background: Although practitioners overwhelmingly agree on the importance of advance care planning (ACP) and preparing for the end of life (EOL), the process is fraught with barriers. Objective: The goal of this research was to explore potential connections between providers’ own personal experiences and current professional practices in ACP and EOL care. Design: A cross-sectional survey design, gathering voluntary, anonymous responses from participants between August and December 2016. The survey sought information from providers in 3 distinct areas: (1) personal experiences of loss, (2) personal ACP, and (3) professional practices related to ACP and EOL care. Setting/Participants: One hundred and ninety health-care professionals (primarily physicians, nurses, and social workers) participated in the survey across a greater, Metropolitan area in the Midwest. Measurements: Questions for professional practices were subscales from the End-of-Life Professional Caregiver Survey: Patient- and Family-Centered Communication (PFCC) and Effective Care Delivery (ECD). Questions developed by the research team were evaluated by judges chosen for clinical and/or research expertise. Results: Numerous connections were found between professionals’ histories of loss, personal ACP, and professional practices. For example, both clinicians with personal experience caring for someone who is dying and clinicians who had completed their own ACP scored higher in both PFCC and ECD and were more likely to refer patients to hospice and palliative care. Conclusions: Results support educational interventions involving opportunities for reflection and completion and communication about ACP. Additionally, educational opportunities for students in health care should focus on incorporating both ACP and greater exposure to hospice and palliative care.
Testosterone Replacement Therapy in Deficient Patients With Chronic Heart Failure
Authors: Navarro-Peñalver Marina , Perez-Martinez M. Teresa , Gómez-Bueno Manuel , García-Pavía Pablo , Lupón-Rosés Josep , Roig-Minguell Eulalia , Comin-Colet Josep , Bayes-Genis Antoni , Noguera Jose A. , Pascual-Figal Domingo A. 
Published: June 2018

Background: Testosterone deficiency is associated with heart failure (HF) progression and poor prognosis. Testosterone therapy has been shown to improve exercise capacity in patients with chronic HF, but no trial has evaluated the impact of replacement in patients with demonstrated testosterone deficiency. Methods: Prospective, randomized, double-blind, placebo-controlled, and parallel-group trial comparing testosterone replacement with placebo in males with chronic HF with reduced ejection fraction (HFrEF) and testosterone deficiency (NCT01813201). Long-acting undecanoate testosterone at a fixed dose of 1000 mg was supplied by intramuscular injection at inclusion and then every 3 months. The placebo group received isotonic saline serum. Patients were randomly allocated 1:1 to testosterone or placebo while receiving optimal medical therapy, and the study was conducted for 12 months. Results: The final sample comprised 29 patients, 15 in the placebo group and 14 in the testosterone group (aged 65 ± 8, 62% with an ischemic etiology, left ventricular ejection fraction [LVEF] 30% ± 6%, 69% New York Heart Association functional [NYHA II]). After 12 months, testosterone replacement increased testosterone levels ( P = .002) but was not associated with benefit in terms of clinical symptoms and functional capacity including NYHA class, Framingham score, Minnesota Living Heart Failure Questionnaire, 6-minute walk test, or LVEF and N-terminal pro-B-type natriuretic peptide levels. No significant side effects associated with testosterone treatment were observed. No effects were found in other hormonal, metabolic, and bone turnover biomarkers. Conclusion: In patients with HFrEF and testosterone deficiency, replacement therapy was not associated with any significant improvement.