bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tekstil Sektöründe İş Kazalarına Sebep Olan Risk Faktörlerinin DEMATEL Yöntemiyle Analizi
Authors: EFE Ömer Faruk , EFE Burak 
Published: August 2019

Günümüzde rekabetin ve sürekli
iyileştirmenin en önemli unsurlarından birisi de iş sağlığı ve güvenliği çalışmalarıdır. İş sağlığı ve güvenliği
uygulamalarının etkinliği işletmelerin ve çalışanların performansını uzun dönemde
olumlu etkilemektedir. Çalışma ortamında üretim verimliliğini ve çalışan
sağlığını olumsuz etkileyen birçok risk faktörü bulunmaktadır. Bunların tespit
edilmesi ve çalışma ortamından uzaklaştırılması işletmenin ve çalışanın güvenliği
açısından önemlidir. Bu çalışmada tekstil sektöründe, iş kazalarına sebep olan
risk faktörleri incelenmiştir. Kazalar üzerinde etkili olan risk faktörleri ve
birbirleri arasındaki etkileri daha net ve doğru olarak belirlenebilirse,
yapılacak iş sağlığı ve güvenliği uygulamalarının da etkinliği o düzeyde artacaktır.
İş kazasına sebep olan risk faktörlerinin birbirleri arasındaki ilişki DEMATEL
yöntemi ile araştırılmıştır. Sonuç olarak “yönetim-işveren algıları” kriterinin
diğer risk faktörlerini daha çok etkilediği tespit edilmiştir. Yönetim-işveren
algısında oluşturulabilecek iyileşmeler ile diğer risk faktörlerinin etkinliği
ve kazaların gerçekleşme durumu azaltılacaktır. Diğer kriterleri en az
etkileyen ve en fazla etkilenen faktör ise “biyolojik faktörler” olarak
bulunmuştur.
Bazı Antidepresan ve Antiepileptik İlaçların İnsan Kanında Eş Zamanlı Analizi için LC-MS/MS Yöntemi Geliştirilmesi
Authors: TEMEL Mehmet Kamil , AKSU Osman , KAYA Ertuğrul , DÖNMEZ Mert , ERGUN Ümit 
Published: August 2019

Bu çalışmada, sık kullanılan
antidepresan ilaç etken maddeleri olan Paroksetin, Sitolapram, Essitolapram,
Venlafaksin ile antiepileptik ilaç etken maddeleri olan Karbamazepin ve
Oxkarbamazepin moleküllerinin tayini için, insan kanında Sıvı
Kromatografisi-Kütle Spektrometresi (LC-MS/MS) cihazı ile basit, hızlı ve
güvenilir olan bir metot geliştirilmiştir. Her bir ilaç etken maddesi için geri
kazanım, doğruluk, yüzde bağıl standart sapma (%RSD), gözlenebilme sınırı (LOD)
ve alt tayin sınırı (LOQ) gibi bazı analitik parametrelerin belirlenip,
ölçülebilir en düşük değerlerin yüksek hassasiyet ile en kısa sürede eş zamanlı
olarak yapılması amaçlanmıştır. Etken maddelerin her biri için belirlenen konsantrasyonlarda;
LOD değerleri 0,06-0,36 ng.mL-1, LOQ değerleri ise 0,21-1,21 ng.mL-1 aralığında elde
edilmiştir. Gün içi tekrarlanabilirlik değerlerinde %RSD sonuçları 0,15-10,71
ng.mL-1, günler arası tekrarlanabilirlik değerlerinde ise %RSD
sonuçları 0,23-13,75 ng.mL-1 aralığında bulunmuştur.
Pb(NO3)2 Toksisitesine Karşı Nigella sativa L.’nin In vivo Koruyucu Rolü
Authors: YAPAR Kürşad , ÇAVUŞOĞLU Kültiğin , YALÇIN Emine , ACAR Ali , DEMİRTAŞ Güray 
Published: August 2019

In
this study, the protective role of Nigella
sativa L. seed extract (NSSE) against Pb(NO3)2
toxicity in albino mice was investigated. For this purpose, the mice were
randomly divided to six groups. In control group, mice were treated with tap
water and in the treatment groups 500 mg kg-1 bw Pb(NO3)2,
300 and 600 mg kg-1 bw doses of NSSE were exposed to mice. The
effects of all treatments on organism development were investigated by
determining the changes in body, liver and kidney weights of each group.
Genotoxic effects were determined by investigating the chromosomal
abnormalities (CAs) in bone marrow cells, micronucleus (MN) frequency in
erythrocyte and buccal mucosa cells. As a result, it was observed that Pb(NO3)2 treatment resulted in a 6.33-fold decrease in
body weight gain and 2.08 and 1.65-fold increase in liver and kidney weights
compared to control group, respectively. In addition, it was determined that
these alterations in weights were positively changed after NSSE treatment. From
MN assays it was observed that MN frequencies of erythrocyte and buccal mucosa
cells in 500 mg kg-1 bw
Pb(NO3)2 treated group were found as
58.17±5.46 and 19.00±2.76 while in 600 mg kg-1 bw NSSE+Pb(NO3)2
treated group, the frequencies were determined as 32.67±3.78 and
6.50±1.87, respectively. A similar protective role was also observed against
CAs formation, and 600 mg kg-1 NSSE treatment was found to reduce
the chromatid breaks by 44%. As a result, it has been determined that NSSE can
be used as a protective nutrient against the harmful effects of chemicals such
as heavy metals especially Pb.
3B Basılabilir Füme Silika Takviyeli Foto-Duyarlı Polimerlerin Mekanik Özelliklerinin İncelenmesi
Authors: SARAÇ Mehmet , ORANLI Aslı , AKTİTİZ İsmail , SAYGI YALÇIN Berrin , VAROL Remzi 
Published: August 2019

Son yıllarda, eklemeli imalat sektörü
ve teknolojisinin ilgisine ve önemine paralel olarak, üç boyutlu (3B) parça
üretimi için kullanılan fotokürlenebilir polimer reçineler üzerine yapılan
çalışmalar büyük ilgi görmektedir. Eklemeli imalat yöntemlerinden biri olan
Streolitografi (SLA) yöntemi, yüksek hızlı işleme ve parça üretimi hassasiyeti
açısından diğer yöntemlerden ayrılmasının yanı sıra mekanik ve diğer
karakteristik özelliklerinin değiştirilmesine izin vermektedir. Özellikle
polimer kompozit malzemelerin mekanik dayanımını arttırmak için birçok çalışma
günümüze kadar yapılmaktadır. Kil, Al2O3, SiO2,
BaTiO3, ZrO2 gibi seramik malzemeler mekanik dayanımı
artırmak için takviye malzemesi olarak örnek verilebilir. Bu çalışmada, dört farklı (katkısız, %0,25,
%0,5, %1) konsantrasyona sahip füme silika katkılı polyester esaslı akrilat
fotokürlenebilir reçinenin mekanik özelliklerine etkisi araştırılmıştır. 167m2/gr
yüzey alanına sahip füme silika %0,25, %0,5 ve %1 konsantrasyonlarında
fotokürlenebilir reçineye eklenmiştir. Çekme testi, dinamik mekanik analiz
(DMA) ve taramalı elektron mikroskobu (SEM) sonuçlarına göre, SLA
kompozitlerinin artan füme silika konsantrasyonu ile birlikte mekanik
dayanımının artmasına rağmen termal kararlılığında azalma (depolama ve kayıp modülü) görülmüştür. Füme
silikanın yüksek yüzey alanı nedeniyle, fotokürlenebilir reçine içerisinde %1
konsantrasyonuna kadar nispeten daha iyi homojen dağıldığı olduğu
gözlemlenmiştir.
Materialización de la norma. Citas y reiteraciones en la colección Juan Bautista Simoni
Authors: Arqueros Guadalupe 
Published: August 2019

Este artículo retoma el concepto de norma desarrollado por Judith Butler y analiza la producción de sujetos generizados en fotografías, visualizando citas y parodias, lugares de eficacia, fallas y fracturas. Utilizando la noción de norma como forma de producción del estándar común, regulador de los fenómenos sociales y como medida de comparación y referencia del grupo consigo mismo. Teniendo en cuenta que no es externa al campo de su aplicación y no solo es responsable de originarlo, sino que confiere realidad. Su poder se origina en la cita y la reiteración. El análisis de la colección fotográfica Juan Bautista Simoni (Ca. 1900) nos permitirá ver cómo el campo de eficacia de las normas es el telón de fondo sobre el cual se recorta el género en sus dimensiones idealizadas y las maneras en que el dispositivo fotográfico funciona integrando un régimen sexual regulador. En este marco se explora el modo en que las imágenes han funcionado como construcciones discursivas de cuyo seno nacen sujetos que reiteran la regulación de lo masculino y lo femenino, como verdades naturales ahistóricas. Además, nos interesa reflexionar sobre cómo las fotografías cimentan identidades genéricas débilmente formadas humanizando y enmarcando los cuerpos en un régimen biopolítico que, aunque con pliegues y fracturas, resulta igualmente eficaz. El presente trabajo se encuadra en la tradición de los estudios de géneros, entendidos como prácticas de crítica cultural; en tanto interpela los procesos de producción ideológica de signos en la presentación y representación de las imágenes.
La era menemista del PAMI. Una aproximación al pasado reciente de la obra social de los jubilados en Argentina
Authors: Minoldo Sol 
Published: August 2019

Orientado principalmente a la cobertura de personas jubiladas, el PAMI constituye una institución clave en la mediación del acceso de las personas mayores argentinas a la cobertura de salud. Sin embargo, los antecedentes de estudio específicamente centrados en este organismo son llamativamente escasos. Este trabajo propone reconstruir una aproximación a la etapa de gestión menemista del instituto a través del relato documentado de la prensa escrita. Para ello, sistematiza la información publicada por tres periódicosde tirada nacional con diferentes líneas editoriales (La Nación, Página12 y Clarín). En el periodo de 6 años que abarca el análisis, se implementaron en PAMI diferentes modelos de gestión y de gobierno, el organismo acumuló una deuda asfixiante, la salud de las personas mayores fue puesta en riesgo debido a reiteradas interrupciones de la atención así como a diversas falencias y demoras, y fue afectada fuertemente la estructura y economía del sistema nacional de prestadores de salud.
IN SILICO DESIGN OF POTENTIAL 1, 5-BENZOTHIAZEPINE DERIVATIVES AS AN ANTI - CONVULSANT AGENT BY MOLECULAR DOCKING STUDIES
Authors: Smita Parjane , Rahul Kunkulol , Dattatray Nandal 
Published: August 2019

Epilepsy is characterized by the presence of recurrent seizures. A seizure can be defined as “an episodic disturbance of movement, feeling, or consciousness caused by sudden synchronous, inappropriate, and excessive electrical discharges in the cerebral cortex”. One in every three patients with epilepsy is probable to be severely disabled. It is continuing this scenario as an attempt to develop potent and nontoxic anti-convulsant agents. Recently the discovery of benzothiazepine derivatives as an anticonvulsant agent is a significant area for research in medicinal chemistry as it is free from all side effects which is shown by a developed as an anticonvulsant agent. In this paper, we have presented results of 2D, and 3D docking poses studies of a series of 300 (Three series) molecules containing 1,5-benzothiazepine pharmacophore as anti-convulsant agents. Docking analysis was utilized to predict the mechanism of action of the designed derivatives for anticonvulsant potential. All the molecules exhibited a binding score in the range of -82.61 to - 118.25 kcal/mol. Most active molecules from Series 1, 2 and 3 exhibited hydrogen bond interactions with LEU282B, LEU282B and LEU282B. Also for the selected standard sodium phenytoin showed the hydrogen bond interaction with LYS637A. It was noted that the docking score of 1a to 10a, 101b to 110b and 201c to 210c was almost the same as that of selected standard sodium phenytoin. The protein showed hydrogen bonding with all synthesized compound showed potential against epilepsy with GABA nergic mechanism.
Keywords: Anti-convulsant; 1,5-benzothiazepine; V-Life MDS 4.3.
Антропометричні параметри та показники тканинних компартментів тіла в пацієнтів із хронічною серцевою недостатністю і зниженою фракцією викиду лівого шлуночка залежно від втрати маси тіла за останні 6 місяців
Authors: Voronkov L. G. , Voitsekhovska К. V. , Fedkiv S. V. , Koval V. I. 
Published: August 2019

The aim – to compare the anthropometric parameters and body tissue compartments of patients with chronic heart failure (CHF) and reduced left ventricular ejection fraction depending on weight loss ≥ 6 % of total body weight within the previous 6 months.Materials and methods. 77 stable patients with chronic heart failure 25–75 years old, NYHA class II–IV, with left ventricular ejection fraction ≤ 35 % were screened. The criterion for the patients group distribution was the weight loss in the last 6 months ≥ 6 % according to the European guidelines for the diagnosis and treatment of CHF. Body composition was measured by dual-energy X-ray absorptiometry. Patients were included in a clinical compensation phase.Results and discussion. Weight loss ≥ 6 % within the previous 6 months was observed in 34 (44.2 %) patients. Patients with weight loss ≥ 6 % had a significantly smaller fat tissue mass (p=0.002) and lean tissues mass (p=0.039), which was confirmed by comparing the normalized indicators of these tissue arrays relative to growth. The limb muscle mass (p=0.006) and the limb muscle mass index (p=0.002) were significantly less in this group of patients. The number of lost kilograms over the past 6 months correlated inversely with the muscle mass index of limbs (r=–0.411, p=0.001), body weight (r=–0.381, p=0.001), muscle mass of limbs (r=–0.360, p=0.001), hip circumference (r=–0.352, p=0.002), body surface area (r=–0.345, p=0.009), waist circumference (r=–0.334, p=0.003), body mass index (r=–0.330, p=0.004), shoulder arm circumference (r=–0.280, p=0.015), lean tissue mass (r=–0.277, p=0.015), skin-fat fold thickness under the scapula (r=–0.273, p=0.018), fat mass tissue (r=–0.269, p=0.018), the circumference of tense arm (r=–0.262, p=0.023), the ratio of fat tissue to height (r=–0.253, p=0.026), the fat tissue index (r=–0.233, p=0.042), and correlated positively with the percentage of bone tissues (r=0.250, p=0.028).Conclusions. Weight loss ≥ 6 % over the past 6 months in patients with CHF and reduced ventricular ejection fraction was observed in 34 (44.2 %) patients. Patients with CHF and weight loss ≥ 6 % were significantly older, had a higher NYHA class, lower body weight, body mass index, shoulder circumference of a tense and relaxed arm, waist and hip circumferences, thickness skin and fat folds over the biceps, triceps and under the scapula. Patients with a body weight loss of ≥ 6 % over the past 6 months had a significantly lower percentage of fat tissue, fat mass and lean tissue mass, indexes of fat mass and muscular tissue of limbs. Patients in groups did not differ in terms of mineral bone mass.
Клінічний перебіг гострого міокардиту у хворих зі збереженою фракцією викиду лівого шлуночка
Authors: Kovalenko V.  M. , Nesukay E. G. , Cherniuk S. V. , Kirichenko R. M. , Titova N. S. , Giresh I. I. , Dmitrichenko O. V. 
Published: August 2019

The aim – to investigate the dynamic changes of the structural and functional state of the heart and the persistence of cardiac rhythm disorders in patients with acute myocarditis with preserved left ventricular ejection fraction (LV EF) during 6 months of follow-up.Materials and methods. 54 patients with acute myocarditis and preserved LV EF (> 40 %) of the left ventricle (LV) were screened. The examination was performed twice: in the first month from the debut of myocarditis and in 6 months of follow-up. Results and discussion. According to data obtained by CMR, in the 1st month from the disease onset, the early contrast on T1-weighted images and/or the high intensity of the signal on T2 images were detected in all patients, with their percentage being 66.6 % and 62.9 % respectively, and late enhancement was observed in 14.8 % of cases. After 6 months of observation, edema and myocardial hyperemia were detected only in 7.4 and 9.2 % of cases, and fibrotic changes were in 37.0 % of patients, while 59.2 % of patients had no pathological changes on CMR at all. The average number of affected by inflammatory changes LV segments in the 1st month was 2.33±0.23, and after 6 months it decreased to 1.43±0.17 segments (р<0.01). The value of LV EF increased from 47.3±2.3 % in the 1st month to 56.2±2.5 % after 6 months (р<0.05) of follow-up, and detection of non-sustained ventricular tachycardia (NSVT) episodes decreased from 20.4 % cases in the 1st month to 7.4 % of cases after 6 months. According to the results of the correlation analysis, a strong direct correlation was established between the number of LV segments involved in the inflammatory process in the 1st month from the myocarditis onset (r=0.81, р<0.01) as also after 6 months (r=0.72; р<0.01) and the presence of NSVT episodes, that was also confirmed by determining the exact Fisher criterion (p=0.019), statistically reliable correlations of the same direction were also established between the presence of NSVT episodes and fibrotic changes on cardiac MRI.Conclusions. For patients with acute myocarditis with a preserved LV EF, the absence of severe violations of the LV contractile function is characterized by a small amount of inflammatory lesions of myocardium. Clinically significant cardiac rhythm disorders, in particular episodes of non-sustained ventricular tachycardia, can be observed in these patients in the absence of significant violations of the structural and functional heart state and are associated with a greater number of LV segments affected by inflammatory and fibrotic changes.
Прогностичне значення підвищення систолічного артеріального тиску та його корекції в українських пацієнтів з артеріальною гіпертензією: результати когортного дослідження СИСТЕМА-2
Authors: Tseluyko V. I. 
Published: August 2019

The aim – to assess the effect of the systolic blood pressure lowering (SBP) on the decreasing of cardiovascular and cardiocerebral complications in 3 and 12 months after the therapy change in patients aged over 55 years without blood pressure control at the routine GP management. Materials and methods. 102 physicians from various regions of Ukraine took part in СИСТЕМА-2 (Systema-2) study. The study consistently involved patients over the age of 55 who had applied to a GP with an arterial hypertension (a total of 2,040 patients).Results and discussion. Among patients who took antihypertensive drugs (91.6 %), the mean SBP was 167 mm Hg, and the blood pressure target level was observed only in 6.9 % of the cases. After 3 months of treatment mean SBP was 138.0±1.0 mm Hg in group with the combination of indapamide with amlodipine and in group with other antihypertensive treatment – 151.0±4.8 mm Hg. After the one year of observation the most of patients reached the target level of SBP – mean SBP in patients taking the combination of indapamide with amlodipine was 132.0±0.5 mm Hg and other antihypertensive therapy – 136.0±1.4 mm Hg (42 % of patients took 3 and more antihypertensive medicines) (p=0,01). The unfavorable course of hypertension was not associated with the initial level of SBP, but the with level of SBP after 3 months of treatment. The number of non-fatal stroke in the group of patients taking the combination of indapamide with amlodipine was 0.4 %, in the group with other treatment was 1.9 %. Within a year 38 (2 %) patients died. The leading cause of death was cardiovascular diseases – 21 (55 %) patients.Conclusions. Reduction of SBP was significantly higher in the group of patients taking the combination of amlodipine and indapamide after 3 and 12 months. The factor associated with a decrease in the incidence of stroke is the early achievement of the target level of SBP, as evidenced by statistically significant differences in this indicator in patients with stroke and in patients without this complication 3 months after their involvement in the study. The use of the recommended combination therapy for calcium antagonist and diuretic in patients aged over 55 years provides better control of blood pressure and statistically significant decreases in the number of strokes, even in the presence of other factors of an adverse prognosis. Low attachment and withdrawal therapy are associated with a significant deterioration in the prognosis.
Perbanyakan Secara Vegetatif Cacahan Daun Terhadap Pertumbuhan Stek Anggrek Bulan (Phalaenopsis amabilis) Sebagai Tanaman Lanskap
Authors: Jonni Jonni , Rasdanelwati Rasdanelwati 
Published: August 2019

Tanaman hias merupakan elemen lunak pada lanskap yang dipergunakan sebagai dekorasi dalam ruangan atau luar ruangan. Anggrek dikenal sebagai tanaman hias yang sangat indah dan variasinya hampir tidak terbatas dan dapat digunakan sebagai tanaman hias lanskap indoor maupun outdoor. Anggrek bulan (Phalaenopsis amabilis) tanaman yang tumbuh tegak, dapat dijumpai pada daerah hutan tropis basah, memiliki beragam keunikan, antara lain bunga yang indah dengan warna-warni yang menarik sehingga banyak dijadikan sebagai tanaman lanskap. Untuk mempercepat perbanyakan dan menghasilkan bibit yang sama dengan induknya dan dalam waktu yang cepat, jumlah yang banyak, dilakukan teknologi stek daun dengan cara mencacah daun. Tujuan dari penelitian ini adalah mendapatkan teknologi perbanyakan tanaman hias anggrek phaleonopsis, dan mendapatkan bagian daun yang terbaik untuk dijadikan bahan perbanyakan pada tanaman hias anggrek phaleonopsis sebagai tanaman lanskap. Penelitian ini dilaksanakan dari bulan Maret sampai Agustus 2018 bertempat kebun percobaan Politeknik Pertanian Negeri Payakumbuh. Metode penelitian yang digunakan adalah Rancangan Acak Lengkap (RAL) yang terdiri atas 4 perlakukan dan 4 ulangan, dengan variabel yang diamati dan diukur adalah waktu muncul kalus, jumlah cacahan berkalus, jumlah berkecambah, dan persentasi cacahan. Hasil perbanyakan tanaman anggrek dengan cacahan daun tidak berpengaruh terhadap waktu muncul kalus, jumlah kalus, jumlah berkecambah, namun berpengaruh nyata terhadap persentase hidup cacahan. Cacahan pada pangkal daun anggrek merupakan yang terbaik dari pada daun utuh, cacahan tengah, dan cacahan ujung daun anggrek sebagai tanaman lanskap. Disarankan dalam penelitian selanjutnya dilakukan cacahan pada ujung daun anggrek dengan berbagai media tanam tanaman lanskap.
GLYCEMIC STATUS AND THE MARKERS OF INFLAMMATION: A COMPARATIVE STUDY IN PATIENTS WITH PRE-DIABETES AND DIABETES
Authors: Shrestha Shailaza , Sharma Dr. Preeti , Kumar Dr. Pradeep , Prasad Dr. Mahendra 
Published: August 2019

Background: Subclinical inflammation characterized by elevated inflammatory markers is found in diabetic patients. Inflammation, an important cardiovascular risk factor, is elevated in diabetics with poor glycemic control than those with good control.
Aim: To study the effect between glycemic status on inflammatory markers in pre-diabetes and diabetes.
Methods: This study included 300 subjects divided into 3 groups; Control: 100, Pre-diabetes: 100 patients and Diabetes: 100 patients. Basic details of all the participants like age and gender were recorded and laboratory investigations like fasting blood sugar (FBS), glycosylated hemoglobin (HbA1c), IL-6, CRP, fibrinogen, uric acid and adiponectin were conducted.
Results: Compared to controls, the levels FBS, HbA1c, IL-6, CRP, fibrinogen and uric acid were elevated and adiponectin was decreased in pre-diabetes and diabetes. The inflammatory parameters (IL-6, CRP, fibrinogen, uric acid and adiponectin) were significantly correlated with glycemic parameters (FBS, HbA1c) in diabetes, i.e. r=0.28, r=0.55, r=0.2, r=0.48 and r=-0.4 respectively in case of FBS and r=-0.39, r=0.48, r=0.21, r=0.33 and r=-0.53 respectively for HbA1c. Similarly, in pre-diabetes, FBS correlated significantly with adiponectin (r=-0.19), fibrinogen (r=0.29) and uric acid (r=0.18) while that with HbA1c was significant with adiponectin (r=-0.31), IL-6 (r=0.25), CRP (r=0.21) and fibrinogen (r=0.3).
Conclusion: The strong correlations observed between glycemic control parameters and inflammation parameters in pre-diabetes and diabetes suggested the crucial involvement of inflammation in the diabetes development. So better control of glycemia can cause significant reduction in inflammation and arrest the health burden.
Key words: Glycemic control, Pre-diabetes, Diabetes, Inflammation.