bluuebunny/crossref_metadata_2025_split huggingface dataset:
Smartphone-based migraine behavioral therapy: a single-arm study with assessment of mental health predictors
Authors: T. Minen Mia , Adhikari Samrachana , K. Seng Elizabeth , Berk Thomas , Jinich Sarah , W. Powers Scott , B. Lipton Richard 
Published: June 2019

AbstractProgressive muscle relaxation (PMR) is an under-utilized Level A evidence-based treatment for migraine prevention. We studied the feasibility and acceptability of smartphone application (app)-based PMR for migraine in a neurology setting, explored whether app-based PMR might reduce headache (HA) days, and examined potential predictors of app and/or PMR use. In this single-arm pilot study, adults with ICHD3 migraine, 4+ HA days/month, a smartphone, and no prior behavioral migraine therapy in the past year were asked to complete a daily HA diary and do PMR for 20 min/day for 90 days. Outcomes were: adherence to PMR (no. and duration of audio plays) and frequency of diary use. Predictors in the models were baseline demographics, HA-specific variables, baseline PROMIS (patient-reported outcomes measurement information system) depression and anxiety scores, presence of overlapping pain conditions studied and app satisfaction scores at time of enrollment. Fifty-one patients enrolled (94% female). Mean age was 39 ± 13 years. The majority (63%) had severe migraine disability at baseline (MIDAS). PMR was played 22 ± 21 days on average. Mean/session duration was 11 ± 7 min. About half (47%) of uses were 1+ time/week and 35% of uses were 2+ times/week. There was a decline in use/week. On average, high users (PMR 2+ days/week in the first month) had 4 fewer days of reported HAs in month 2 vs. month 1, whereas low PMR users (PMR < 2 days/week in the first month) had only 2 fewer HA days in month 2. PROMIS depression score was negatively associated with the log odds of using the diary at least once (vs. no activity) in a week (OR = 0.70, 95% CI = [0.55, 0.85]) and of doing the PMR at least once in a week (OR = 0.77, 95% CI = [0.68, 0.91]). PROMIS anxiety was positively associated with using the diary at least once every week (OR = 1.33, 95% CI = [1.09, 1.73]) and with doing the PMR at least once every week (OR = 1.14 [95% CI = [1.02, 1.31]). In conclusion, about half of participants used smartphone-based PMR intervention based upon a brief, initial introduction to the app. App use was associated with reduction in HA days. Higher depression scores were negatively associated with diary and PMR use, whereas higher anxiety scores were positively associated.
The ChlD subunit links the motor and porphyrin binding subunits of magnesium chelatase
Authors: Farmer David A. , Brindley Amanda A. , Hitchcock Andrew , Jackson Philip J. , Johnson Bethany , Dickman Mark J. , Hunter C. Neil , Reid James D. , Adams Nathan B. P. 
Published: June 2019

Abstract
Magnesium chelatase initiates chlorophyll biosynthesis, catalysing the MgATP2−-dependent insertion of a Mg2+ ion into protoporphyrin IX. The catalytic core of this large enzyme complex consists of three subunits: Bch/ChlI, Bch/ChlD and Bch/ChlH (in bacteriochlorophyll and chlorophyll producing species, respectively). The D and I subunits are members of the AAA+ (ATPases associated with various cellular activities) superfamily of enzymes, and they form a complex that binds to H, the site of metal ion insertion. In order to investigate the physical coupling between ChlID and ChlH in vivo and in vitro, ChlD was FLAG-tagged in the cyanobacterium Synechocystis sp. PCC 6803 and co-immunoprecipitation experiments showed interactions with both ChlI and ChlH. Co-production of recombinant ChlD and ChlH in Escherichia coli yielded a ChlDH complex. Quantitative analysis using microscale thermophoresis showed magnesium-dependent binding (Kd 331 ± 58 nM) between ChlD and H. The physical basis for a ChlD–H interaction was investigated using chemical cross-linking coupled with mass spectrometry (XL–MS), together with modifications that either truncate ChlD or modify single residues. We found that the C-terminal integrin I domain of ChlD governs association with ChlH, the Mg2+ dependence of which also mediates the cooperative response of the Synechocystis chelatase to magnesium. The interaction site between the AAA+ motor and the chelatase domain of magnesium chelatase will be essential for understanding how free energy from the hydrolysis of ATP on the AAA+ ChlI subunit is transmitted via the bridging subunit ChlD to the active site on ChlH.
The search for candidate genes associated with natural variation of grain Zn accumulation in barley
Authors: Detterbeck Amelie , Nagel Manuela , Rensch Stefan , Weber Michael , Börner Andreas , Persson Daniel P. , Schjoerring Jan Kofod , Christov Vesselin , Clemens Stephan 
Published: June 2019

Abstract
Combating hidden hunger through molecular breeding of nutritionally enriched crops requires a better understanding of micronutrient accumulation. We studied natural variation in grain micronutrient accumulation in barley (Hordeum vulgare L.) and searched for candidate genes by assessing marker-trait associations (MTAs) and by analyzing transcriptional differences between low and high zinc (Zn) accumulating cultivars during grain filling. A collection of 180 barley lines was grown in three different environments. Our results show a pronounced variation in Zn accumulation, which was under strong genotype influence across different environments. Genome-wide association mapping revealed 13 shared MTAs. Across three environments, the most significantly associated marker was on chromosome 2H at 82.8 cM and in close vicinity to two yellow stripe like (YSL) genes. A subset of two pairs of lines with contrasting Zn accumulation was chosen for detailed analysis. Whole ears and flag leaves were analyzed 15 days after pollination to detect transcriptional differences associated with elevated Zn concentrations in the grain. A putative α-amylase/trypsin inhibitor CMb precursor was decidedly higher expressed in high Zn cultivars in whole ears in all comparisons. Additionally, a gene similar to barley metal tolerance protein 5 (MTP5) was found to be a potential candidate gene.
The β-hairpin region of the cyanobacterial F1-ATPase γ-subunit plays a regulatory role in the enzyme activity
Authors: Akiyama Kentaro , Kondo Kumiko , Inabe Kosuke , Murakami Satoshi , Wakabayashi Ken-ichi , Hisabori Toru 
Published: June 2019

Abstract
The γ-subunit of cyanobacterial and chloroplast ATP synthase, the rotary shaft of F1-ATPase, equips a specific insertion region that is only observed in photosynthetic organisms. This region plays a physiologically pivotal role in enzyme regulation, such as in ADP inhibition and redox response. Recently solved crystal structures of the γ-subunit of F1-ATPase from photosynthetic organisms revealed that the insertion region forms a β-hairpin structure, which is positioned along the central stalk. The structure–function relationship of this specific region was studied by constraining the expected conformational change in this region caused by the formation of a disulfide bond between Cys residues introduced on the central stalk and this β-hairpin structure. This fixation of the β-hairpin region in the α3β3γ complex affects both ADP inhibition and the binding of the ε-subunit to the complex, indicating the critical role that the β-hairpin region plays as a regulator of the enzyme. This role must be important for the maintenance of the intracellular ATP levels in photosynthetic organisms.
Cratering and age of the small Saturnian satellites
Authors: Rossignoli N. L. , Di Sisto R. P. , Zanardi M. , Dugaro A. 
Published: June 2019

Context. The small (≤135 km mean radius) satellites of Saturn are closely related to its rings and together they constitute a complex dynamical system where formation and destruction mechanisms compete against each other. The Cassini-Huygens mission provided high-resolution images of the surfaces of these satellites and therefore allowed for the calculation of observational crater counts.
Aims. We model the cratering process by Centaur objects on the small Saturnian satellites, and compare our results with the observational crater counts obtained from the Voyager and Cassini missions.
Methods. Using a theoretical model previously developed we calculate the crater production on these satellites considering two slopes of the size-frequency distribution (SFD) for the smaller objects of the Centaur population and compare our results with the available observations. In addition, we consider the case of catastrophic collisions between these satellites and Centaur objects and calculate the age of formation of those satellites that suffer one or more disruptions.
Results. In general we find that the observed crater distributions are best modeled by the crater size distribution corresponding to the s2 = 3.5 index of the SFD of impactors with diameters smaller than 60 km. However, for crater diameters D ≲ 3–8 km (which correspond to impactor diameters d ~ 0.04–0.15 km), the observed distributions become flatter and deviate from our results, which may evidence processes of erosion and/or crater saturation at small crater sizes or a possible break in the SFD of impactors at d ~ 0.04–0.15 km to a much shallower differential slope of approximately − 1.5. Our results suggest that Pan, Daphnis, Atlas, Aegaeon, Methone, Anthe, Pallene, Calypso, and Polydeuces suffered one or more catastrophic collisions over the age of the solar system, the younger being associated to arcs with ages of ~108 yr. We have also calculated surface ages for the satellites, which indicate ongoing resurfacing processes.
Nosokomiale Pneumonie – neue Leitlinien
Authors: Kramme Evelyn , Dalhoff Klaus 
Published: June 2019

Was ist neu?
Erregerspektrum: Die Rolle multiresistenter Erreger Das nationale Referenzzentrum verzeichnet insgesamt eine Zunahme der Nachweise gramnegativer multiresistenter Erreger (MRE), was sich nach bisheriger Datenlage noch nicht auf das Erregerspektrum der HAP (hospital aquired pneumonia) ausgewirkt hat. Das individuelle Risikoprofil für das Auftreten von MRE bleibt entscheidend für die kalkulierte Therapie.
Diagnostik Als ergänzende diagnostische Maßnahme wurde die Thoraxsonografie in die Empfehlung aufgenommen. Besondere Bedeutung misst die Leitlinie der Messung von PCT und Laktat bei, um frühzeitig eine Sepsis/einen septischen Schock zu erkennen. Als Empfehlung zur virologischen Diagnostik kam die Durchführung einer PCR in der Influenza-Saison hinzu.
Kalkulierte Therapie: Initial Mono- oder Kombinationstherapie? Eine Kombinationstherapie wird nur noch bei sehr schwerer Erkrankung (invasive Beatmung, septischer Schock) und hohem Risiko für MRE empfohlen, da sie sich in zahlreichen Studien nur in diesen Konstellationen als überlegen erwiesen hat. Es wird eine deutliche Empfehlung zur zügigen Deeskalation nach klinischen und mikrobiologischen Kriterien ausgesprochen.Aufgrund pharmakokinetischer/pharmakodynamischer Erwägungen sollte bei Patienten mit Sepsis/septischem Schock in der Initialphase eine prolongierte Infusion von hierfür geeigneten Betalaktam-Antibiotika nach initialer Kurzinfusion erwogen werden.
Inhalative Therapie Eine adjunktive aerosolierte Therapie sollte nur in erfahrenen Zentren bei Nachweis von Erregern mit multiplen Resistenzen durchgeführt werden, wenn der Therapieerfolg einer systemischen Therapie fraglich ist.
Die Polypill – Ein praktikables Konzept?
Authors: Thürmann Petra A. , Kleinerüschkamp Adina G. , Boehme Philip 
Published: June 2019

Was ist neu?
Vor- und Nachteile des Polypill-Konzepts Polypills können die Therapieadhärenz erhöhen, während insbesondere die Aspekte aus ärztlicher Sicht Therapiesicherheit und -flexibilität das Thema aktueller Diskussionen sind.
Die Polypill in der Primärprävention Aufgrund der Nichtberücksichtigung individueller Risikofaktoren durch ihren „Massenmedikations“-Ansatz sollte die Polypill zur Primärprävention nur einem ausgewählten Hochrisikopatientengut vorbehalten bleiben.
Sekundärprävention bei bereits optimal eingestellten Patienten sowie Primärprävention bei Hochrisikopatienten Zukünftige Studien müssen zeigen, dass die Anwendung von Polypills nicht nur einen positiven Einfluss auf Adhärenz und Surrogatparameter hat, sondern auch zu einer Reduktion kardiovaskulärer Ereignisse und letztendlich der Letalität führt.
Chancen und Grenzen eines zeitgemäßen Onlineauftrittes für Urologen
Authors: Cebulla Angelika , Marx Maria , Struck Julian Peter 
Published: June 2019

Zusammenfassung
Hintergrund Eine angemessene und zeitgemäße Onlinepräsenz hat unter Medizinern und speziell Urologen zunehmend an Relevanz gewonnen. Studien konnten zeigen, dass Patienten vermehrt Onlineangebote nutzen, um sich über Gesundheitsthemen zu informieren. Neben dem reinen Informationserhalt gewinnt der Onlineauftritt bei der Arztsuche und für die Arzt-Patienten-Kommunikation immer mehr an Bedeutung. Zudem nutzen Fachgesellschaften und Journals soziale Medien, um ihre Reichweite in der urologischen bzw. medizinischen Welt zu maximieren.
Ziel der Arbeit Diese Arbeit soll Chancen und Risiken des urologischen Onlineauftrittes aufzeigen und Hinweise zur Umsetzbarkeit geben.
Ergebnisse Eine professionelle sowie visuell ansprechende Homepage ist ein wichtiges Werkzeug im Patientenkontakt. Beim Aufbau einer professionellen, digitalen Identität gilt es sowohl rechtliche als auch strategische Gesichtspunkte zu beachten. Es existieren bereits Leitfäden und Empfehlungen, die Hinweise zum Umgang mit sozialen Medien und zur inhaltlichen Gestaltung von Homepages geben. V. a. die rechtlichen Auflagen sind komplex, hier bedürfen Mediziner einer eingehenden, professionellen Beratung.
Diskussion Unabhängig vom Medium ist ein sensibler Umgang mit online veröffentlichten Inhalten anzuraten. Hierbei empfiehlt sich eine strenge Trennung von privaten und professionellen Onlineauftritten. Weiterhin sollten die Ziele des eigenen Internetauftrittes in regelmäßigen Abständen reevaluiert und ggf. angepasst werden.
MR Imaging of the Hip: An Update on Bone Marrow Edema
Authors: Vassalou Evangelia E. , Spanakis Konstantinos , Tsifountoudis Ioannis P. , Karantanas Apostolos H. 
Published: June 2019

AbstractBone marrow edema (BME) represents a frequent and easily detected MR imaging finding that is recognized as a common source of pain. It is considered a nonspecific finding that constitutes a central component of a wide spectrum of pathologies affecting the hip joint, showing high variability in terms of prognosis and treatment requirements. Solid knowledge of the various BME patterns and associated imaging findings indicative of these conditions can aid in differentiation. Additionally, correlation with clinical and laboratory data are essential for arriving at a final diagnosis in several cases. In this review, we describe the disease characteristics and imaging findings and also highlight the differential diagnostic clues regarding common hip disorders associated with BME including avascular necrosis, transient osteoporosis, stress injuries, and infectious/inflammatory disorders.
Conventional and Arthrographic Magnetic Resonance Techniques for Hip Evaluation: What the Radiologist Should Know
Authors: Schmaranzer Florian , Cerezal Luis , Llopis Eva 
Published: June 2019

AbstractOver the last 2 decades, the definition of pathomechanical concepts that link osseous deformities to chondrolabral damage and expose young and active patients to the risk of early osteoarthritis has led to a tremendous increase in the number of joint-preserving surgeries performed. The rise in arthroscopic procedures has led to an increasing demand for comprehensive preoperative magnetic resonance imaging (MRI) assessment of the hip joint. This includes conventional MRI for the assessment of extra-articular and periarticular pathologies such as greater trochanteric pain, deep gluteal pain syndrome, and sports injuries. Magnetic resonance arthrography with or without traction is reserved for the accurate evaluation of deformities associated with impingement and hip instability and for detecting the resulting intra-articular lesions. This article summarizes the current standard imaging techniques that the radiologist should know. It also explores the potential of computer-assisted analysis of three-dimensional MRI for virtual impingement simulation and volumetric analysis of cartilage composition and geometry.
Ultrasound-guided Musculoskeletal Interventions for the Most Common Hip and Pelvis Conditions: A Step-by-Step Approach
Authors: Allen Georgina , Obradov Marina , Chianca Vito , Messina Carmelo , Sconfienza Luca Maria 
Published: June 2019

AbstractPain around the hip and pelvis is a very common condition. Pain may be generated within the joint space (i.e. the hip joint itself, the sacroiliac joints or the pubic symphysis) or from surrounding myotendinous, bursal, or nerve structures. Over the years, percutaneous musculoskeletal procedures have become increasingly popular to diagnose and treat painful conditions around the hip and the pelvis. Most intra- and extra-articular procedures are performed under ultrasound guidance. This article reviews the most common diagnostic and therapeutic procedures that can be performed around the hip and the pelvis under ultrasound guidance.
Artificial Intelligence in Musculoskeletal Imaging: Review of Current Literature, Challenges, and Trends
Authors: Hirschmann Anna , Cyriac Joshy , Stieltjes Bram , Kober Tobias , Richiardi Jonas , Omoumi Patrick 
Published: June 2019

AbstractArtificial intelligence (AI) has gained major attention with a rapid increase in the number of published articles, mostly recently. This review provides a general understanding of how AI can or will be useful to the musculoskeletal radiologist. After a brief technical background on AI, machine learning, and deep learning, we illustrate, through examples from the musculoskeletal literature, potential AI applications in the various steps of the radiologist's workflow, from managing the request to communication of results. The implementation of AI solutions does not go without challenges and limitations. These are also discussed, as well as the trends and perspectives.
Update on Whole-body MRI in Musculoskeletal Applications
Authors: Vilanova Joan C. , García-Figueiras Roberto , Luna Antonio , Baleato-González Sandra , Tomás Xavier , Narváez José A. 
Published: June 2019

AbstractWhole-body magnetic resonance imaging (WB-MRI) is a powerful tool increasingly used to assess oncologic and nononcologic diseases. WB-MRI provides information about diffuse multifocal pathologies with excellent anatomical definition through high soft tissue contrast and spatial resolution as well as valuable functional information from diffusion-weighted images. In addition to its roles in establishing the diagnosis and assessing the extent and severity of disease, WB-MRI is also useful for monitoring the response to treatment for malignant and benign systemic diseases affecting the musculoskeletal system. This article reviews and updates the applications of WB-MRI in current practice, discussing the role of this helpful tool in various conditions involving the musculoskeletal system including bone metastases, hematologic cancers, inflammatory processes, infections, and multisystemic-multifocal bone, nerve, vascular, and muscle/soft tissue disorders, as well as other idiopathic conditions.
Imaging of Articular and Extra-articular Sports Injuries of the Hip
Authors: Boric Igor , Isaac Amanda , Dalili Danoob , Ouchinsky Michel , De Maeseneer Michel , Shahabpour Maryam 
Published: June 2019

Sports-related articular and periarticular hip injuries are common in athletes. Knowledge of patient complaints and clinical findings are crucial for adequate interpretation of imaging examinations. However, asymptomatic athletes can present abnormal imaging findings, and clinical presentation of hip injuries may be nonspecific. Therefore, a thorough examination of the hip and surrounding soft tissue images is essential.This review describes the intra-articular pathologies encountered in sports activities including labrum or cartilage lesions, associated or not with femoroacetabular hip impingement syndromes, as well as ligament teres injuries, using magnetic resonance imaging (MRI) or computed tomography arthrography. Different causes of snapping hip syndrome (from intra- and extra-articular origins) are also discussed and illustrated. The extra-articular forms of hip impingement syndromes including ischiofemoral and subspine impingement are depicted with MRI and ultrasound. Diagnostic imaging of bone avulsions, greater trochanteric syndrome, athletic pubalgia, and myotendinous injuries is also described.
N-Methyl-D-Aspartate Receptor Encephalitis with Psychiatric Symptoms and an Ovarian Teratoma Detected by MRI in a 17-Year-Old Girl
Authors: Barth A. , Nassenstein I. , Tröbs R.B. , Tannapfel A. , Dercks H. , Rostásy K. , Wegener-Panzer A. 
Published: June 2019

AbstractN-methyl-D-aspartate receptor (NMDAR) encephalitis is a rare antibody-mediated autoimmune encephalitis often associated with an ovarian teratoma in adolescent females. Here we present a 17-year-old girl with only and unusual psychiatric symptoms as part of her NMDAR encephalitis in combination with a very small ovarian teratoma suspected by magnetic resonance (MR) imaging and finally histologically confirmed. We further review the literature of NMDAR encephalitis in combination with an ovarian teratoma and discuss the recommended radiological workup in children with a suspected ovarian tumor.
Kalkulierte parenterale Initialtherapie bakterieller Erkrankungen bei Erwachsenen – Update 2018
Authors: Bodmann Klaus-Friedrich 
Published: June 2019

Was ist neu?
Darstellung und Klassifizierung neuer Substanzen: Bei der Klassifizierung neuer Substanzen werden die neuen Cephalosporin/Betalactamaseinhibitor-Kombinationen sowie die Cephalosporine mit MRSA-Wirksamkeit eingearbeitet.
Pharmakokinetik/Pharmakodynamik: Dieses Kapitel fokussiert auf die Notwendigkeit eines therapeutischen Drug-Monitorings.
Respiratorische Infektionen: Das Kapitel „Respiratorische Infektionen“ vergleicht im Bereich der nosokomialen Pneumonie die S3-Leitlinie mit dem risikoadaptierten Punktescore der PEG.
Sepsis: Im Kapitel „Sepsis“ werden die neuen Sepsisdefinitionen erklärt sowie neue therapeutische Alternativen für die kalkulierte Initialtherapie der Sepsis bei unbekanntem Fokus und beim Fokus Atemwege aufgezeigt.