bluuebunny/crossref_metadata_2025_split huggingface dataset:
“Craving to hear from you…”
Authors: Darden Vicki , Maroney Elisa M. 
Published: November 2018

AbstractThis study examines the feasibility of mobile technology for interpreter education. While interpreter education and its use of technology is well-established and documented in developed countries, educational opportunities for signed language interpreters in developing countries are scarce. One innovation, mobile phone technology, appears to be changing patterns of technological adoption in developed and developing countries, connecting those previously denied access by geography or income. Education through mobile applications, or m-learning, was used to provide professional development to interpreters from the U.S. and Ghana in an action research pilot study. Surveys, discussions, and reflections were analyzed to identify the types of technologies employed, challenges encountered, evidence of learning, and collegial interactions. While successful outcomes were documented, findings indicate feasibility is still dependent on several factors.
Entrepreneurship for religious tourism in Mumbai, India.
Authors: Yasuda S. 
Published: November 2018

Abstract

This chapter first summarizes the concept of entrepreneurship in religious tourism by focusing on the theory of religious economy. It then considers the characteristics of the religious tourism marketplace in Mumbai and India. Subsequently, the management strategy of an Islamic tour operator is described, based on a personal interview with the company's co-manager. The unique management strategy of the Islamic tour operator is summarized by three points: the establishment of a leisure culture based on Islamic value for lower-middle-class people in local communities; the development of customers' religious knowledge and piety through religious tours; and the circulation of the company's profit in the local community.
Religious tourism in the ideological framework of Chinese tourism education.
Authors: Korstanje M. E. , George B. P. 
Published: November 2018

Abstract

This chapter deals with the rise and expansion of Chinese presence in tourism-related studies as well as the limitations of Chinese tourism scholars in conducting applied research, particularly in religious tourism. It also looks at the way religious tourism is treated in Chinese tourism education simply as a business and nothing else. The communist ideology pervading the Chinese education system provides an overarching influence upon what to teach and how. Chinese educational thinkers do not consider it ethical to teach religious tourism to students, yet market forces present tremendous opportunities for the exploitation of the country's religious and cultural heritage.
Objectively measured absolute and relative physical activity intensity levels in postmenopausal women
Authors: Gil‐Rey Erreka , Maldonado‐Martín Sara , Palacios‐Samper Natalia , Gorostiaga Esteban M. 
Published: November 2018

AbstractObjectives: To investigate how objectively measured physical activity (PA) levels differ according to absolute moderate intensity recommendation (3–6 METs) and relative to individual lactate thresholds (LT1 and LT2), and to verify if high‐fit women record higher PA levels compared to women with lower aerobic fitness.Methods: Seventy‐five postmenopausal women performed an incremental exercise test and several constant‐velocity tests wearing an accelerometer to identify the activity counts (ct min−1) corresponding to LT1 and LT2. Individual linear regression determined activity counts cut‐points for each intensity: (1) sedentary (<200 ct min−1), (2) light (from 200 ct min−1 to ct min−1 at LT1), (3) moderate (ct min−1 between LT1 and LT2) and (4) vigorous (ct min−1 > LT2). Participants then wore an accelerometer during a week to measure the time spent at each PA intensity level.Results: According to absolute intensity categorisation, high‐fit postmenopausal women recorded twice as much time at moderate‐to‐vigorous PA (MVPA) (P < 0.01) than low‐fit women. However, when PA intensity was calculated relative to individual lactate thresholds, MVPA was significantly reduced by half (P < 0.01) and the data revealed no differences (P = 0.62) between groups (∼20 min day−1 at MVPA).Conclusions: Accelerometer cut‐points derived from absolute moderate‐intensity recommendations overestimated MVPA. Similar time at MVPA was recorded by high‐ and low‐fit postmenopausal women when the cut‐points were tailored to individual lactate thresholds. A more accurate estimation of PA behaviour could be provided with the use of individually tailored accelerometer cut‐points.
Clogging in two-dimensions: effect of particle shape
Authors: Goldberg Ezequiel , Manuel Carlevaro C , Pugnaloni Luis A 
Published: November 2018

Abstract
We study the discharge of a two-dimensional silo through small openings via discrete element simulations. We consider the effect of the shape of the grains on the clogging of the flow, focusing on regular polygons and disks. We show that the clogging probability presents a non-linear response as a function of the number of vertexes of the polygons. Also, the clogging probability is strongly dependent on the protocol used to trigger the flow after each clog. We found that the size and shape of the blocking arches display a much larger variability for some polygons, particularly for squares, than for disks.
Occupy Climate: Social Movement-Building in Literature, Politics, and the Arts
Authors: LeMenager Stephanie 
Published: November 2018

Abstract
New books by Shelley Streeby, Robert Marzec, and Ashley Dawson point the way toward a cultural criticism for the climate change era. In its own way, each seeks to change the methods of literary and cultural studies, to change the form of the academic monograph, and to encourage a just transition from the radically unequal and ecologically injured world of the now. All three can be seen as contributing to the social and academic movement known as Environmental Justice or Critical Environmental Justice. All three evoke, to some extent, earlier, experimental scholarly works influenced by or generative for the Occupy movement, writings by theorists and practitioners of tactical media like McKenzie Wark and Ricardo Dominguez, and such popular radical thinkers as Mike Davis, Rebecca Solnit, Naomi Klein, and Winona LaDuke. Finally, all three books emerge, somewhat unexpectedly, from literature departments, raising the question of what we mean by literary and cultural studies at this moment in the eclipse of humanism by planetary geology and posthumanist philosophical thought.
Paleontology: advancing China's international leadership
Authors: Jia Hepeng 
Published: November 2018

Abstract
In recent years, Chinese scientists have achieved significant progress in paleontological discoveries and scientific studies. Series of studies published in top journals, such as Science, Nature and Proceedings of the National Academy of Sciences of the United States of America (PNAS), have astonished the world by presenting beautiful fossils that furnish robust evidence to enrich the understanding of organismic evolution, major extinctions and stratigraphy. It has been portrayed as the heyday in the paleontology of China. What is the status of the field? What factors have caused the avalanche of fossil discoveries in China? What implications can these new discoveries provide for our understanding of current evolution theories? How, given their significant contribution to the world's paleontology scholarship, can Chinese scientists play a due leadership role in the field? At an online forum organized by the National Science Review (NSR), its associate editor-in-chief, Zhonghe Zhou, asked four scientists in the field as well as NSR executive editor-in-chief Mu-ming Poo to join the discussion.
Jin Meng

Paleobiologist at American Museum of Natural History
Mu-ming Poo

Neurobiologist at Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences
Shuzhong Shen

Stratigrapher at Nanjing Institute of Geology and Paleontology, Chinese Academy of Sciences
Shuhai Xiao

Paleobiologist and geobiologist at Virginia Polytechnic Institute and State University
Zhonghe Zhou (Chair)

Paleobiologist at Institute of Vertebrate Paleontology and Paleoanthropology (IVPP), Chinese Academy of Sciences
Risk Management in the Ambulatory Care Process in a Mutual Benefit Association Covering Work-Related Accidents and Diseases: Applying Modified Failure Mode and Effect Analysis (FMEA) Methodology
Authors: Grau Norma , Manzanera Rafael , Orrego Carola , Ortner Jordi , Vives Albert , Saurí Carme , Moya Diego , Martínez José Miguel 
Published: November 2018

Aim
To assess the impact of different forms of use of failure mode and effect analysis methodology for risk prioritization in the ambulatory care process in a mutual benefit association covering work-related accidents and diseases.

Methods
The study is based on a previously drafted and individually prioritized risk map by a multidisciplinary team made up of patient safety committee members from health care centers and clinics in a mutual benefit association covering work-related accidents and diseases. The professionals mainly carry out their work in the field of management (individual manager group (IMG)). A group formed by clinicians subsequently completed 2 prioritizations: one based on the individual opinions of each of the members (individual clinical group (ICG)) and another in a consensual way (consensual clinical group (CCG)) as recommended by failure mode and effect analysis methodology. The risk prioritization was compared in the 3 groups (IMG, ICG, and CCG).

Results
The risk prioritization by the IMG defines 7 extreme risks (risk prioritization ≥ 275). When the clinical group prioritizes them in an individual way (ICG), there is no extreme risk, whereas when it does so in a consensual way (CCG), there are 21 extreme risks. With respect to the coincidences of existing causes between the 3 groups, it is noted that the “risk of falls” is rated by both the clinical and the manager group but prioritized differently. On the other hand, the ICG and CCG coincide in that pressure on health care services can contribute to carrying out incomplete anamnesis. They also both consider that internal and external waiting lists and holiday periods can cause a delay in the starting of rehabilitation. The IMG and the CCG show similarity in the risk assessment of overprescribing medication and that multiple computer sessions are initiated. Finally, the IMG and the ICG coincide in the “lack of delivery of the medication leaflet”.

Conclusions
The point of view of the clinicians is important in the risk prioritization of the ambulatory health care process. The difference in the risk prioritization between the clinical group at individual level and after consensus is remarkable.
Design and Usability Testing of the Stroke Caregiver Support System: A Mobile-Friendly Website to Reduce Stroke Caregiver Burden
Authors: Caunca Michelle R. , Simonetto Marialaura , Hartley Gregory , Wright Clinton B. , Czaja Sara J. 
Published: November 2018

Abstract

Purpose
The purpose of this study was to design a mobile-friendly, Internet-based website, modeled on previously described websites for Alzheimer caregivers, to equip stroke caregivers and potentially reduce caregiver burden.

Design
A mixed-methods study was performed to design and test the usability of the Stroke Caregiver Support System (SCSS).

Methods
An iterative, user-centered design approach was employed in three phases: (I) Focus Groups, (II) Structured Interviews, and (III) Usability Testing. Phase I and Phase II provided information for the development of the SCSS website, whereas Phase III helped in gathering data regarding the usability and efficacy of the newly implemented SCSS website.

Findings
Qualitative data on caregiving and the content and design of the SCSS were obtained from focus groups and interviews. In the usability test, the nine caregivers who completed Phase III (78% women, mean age = 46, SD = 17) exhibited a high level of burden and depressive symptoms (median [Q1, Q3] Zarit burden score = 18 [16, 23], Center of Epidemiologic Studies-Depression Scale = 15 [8, 17]). Caregivers conveyed the usability of the SCSS but also expressed several needed improvements.

Conclusions
Participants reported the value of the SCSS, but further refinements are needed to maximize its usability and potential efficacy.

Clinical Relevance
The SCSS has potential to reduce caregiver burden in stroke.
Perinasal Osteotomy With Distraction Osteogenesis for a Mild Syndromic Craniosynostosis
Authors: Kobayashi Shinji , Fukawa Toshihiko , Yasumura Kazunori , Satake Toshihiko , Maegawa Jiro 
Published: November 2018

Abstract
Le Fort II and III procedures have generally been performed for syndromic craniosynostosis with midfacial hypoplasia and skeletal class III malocclusion. However, some patients have midfacial hypoplasia without malocclusion. Perinasal osteotomy was performed with distraction osteogenesis to move the midface forward in 2 patients (a 17-year old female patient with Crouzon-like disease and a 15-year-old female patient with Antely–Bixler syndrome) with mild midface hypoplasia without malocclusion. The success of the procedure was assured by 3 features: the intermaxillary sutures were fixed by a mini metal plate to prevent separation during distraction; the distraction wires were fixed through the bone of the piriform aperture with the mini metal plates to prevent the wires from coming off; and the osteotomy line was designed in front of the palatomaxillary suture to avoid suture damage. These were expected to secure the procedure. Perinasal osteotomy with distraction osteogenesis is considered one of the recommended procedures for mild midfacial hypoplasia as seen in mild syndromic craniosynostosis without malocclusion.
Multiple Patient Casualty Scenarios
Authors: Marlow Shannon L. , Bedwell Wendy L. , Zajac Stephanie , Reyes Denise L. , LaMar Michelle , Khan Saad , Lopreiato Joseph , Salas Eduardo 
Published: November 2018

Introduction
Teamwork is a critical aspect of patient care and is especially salient in response to multiple patient casualties. Effective training and measurement improve team performance. However, the literature currently lacks a scientifically developed measure of team performance within multiple causality scenarios, making training and feedback efforts difficult. The present effort addresses this gap by integrating the input of subject matter experts and the science of multicasualty teams and training to (1) identify overarching teamwork processes and corresponding behaviors necessary for team performance and (2) develop a behavioral observation tool to optimize teamwork in multicasualty training efforts.

Method
A search of articles including team performance frameworks associated with team training was conducted, leading to the identification of a total of 14 articles. Trained coders extracted teamwork processes and the corresponding team behaviors indicative of effective performance from these articles. Five subject matter experts were interviewed using the critical incident technique to identify additional behaviors.

Results
Team situation awareness, team leadership, coordination, and information exchange emerged as the four core team processes required for team performance in scenarios with multiple patient casualties. Relevant behaviors and subbehaviors within these overarching processes were identified to inform a pilot behavioral framework of team performance.

Conclusions
The processes and associated behaviors identified within this effort serve as scientifically grounded behaviors of team performance in the case of multiple patient casualties simulated training scenarios. Future work can use and further refine these results to ensure that measures of team performance are grounded in specific, observable, and scientifically delineated behaviors.
Transcriptional regulatory networks that promote and restrict identities and functions of intestinal innate lymphoid cells
Authors: Pokrovskii Maria , Hall Jason A. , Ochayon David E. , Yi Ren , Chaimowitz Natalia S. , Seelamneni Harsha , Carriero Nicholas , Watters Aaron , Waggoner Stephen N. , Littman Dan R. , Bonneau Richard , Miraldi Emily R. 
Published: November 2018

SummaryInnate lymphoid cells (ILCs) can be subdivided into several distinct cytokine-secreting lineages that promote tissue homeostasis and immune defense but also contribute to inflammatory diseases. Accumulating evidence suggests that ILCs, similarly to other immune populations, are capable of phenotypic and functional plasticity in response to infectious or environmental stimuli. Yet the transcriptional circuits that control ILC identity and function are largely unknown. Here we integrate gene expression and chromatin accessibility data to infer transcriptional regulatory networks within intestinal type 1, 2, and 3 ILCs. We predict the “core” sets of transcription-factor (TF) regulators driving each ILC subset identity, among which only a few TFs were previously known. To assist in the interpretation of these networks, TFs were organized into cooperative clusters, or modules that control gene programs with distinct functions. The ILC network reveals extensive alternative-lineage-gene repression, whose regulation may explain reported plasticity between ILC subsets. We validate new roles for c-MAF and BCL6 as regulators affecting the type 1 and type 3 ILC lineages. Manipulation of TF pathways identified here might provide a novel means to selectively regulate ILC effector functions to alleviate inflammatory disease or enhance host tolerance to pathogenic microbes or noxious stimuli. Our results will enable further exploration of ILC biology, while our network approach will be broadly applicable to identifying key cell state regulators in otherin vivocell populations.
Inferring the direction of rhythmic neural transmission via inter-regional phase-amplitude coupling (ir-PAC)
Authors: Nandi Bijurika , Swiatek Peter , Kocsis Bernat , Ding Mingzhou 
Published: November 2018

ABSTRACTPhase-amplitude coupling (PAC) estimates the statistical dependence between the phase of a low-frequency and the amplitude of a high-frequency component of local field potentials (LFP). Characterizing the relationship between nested oscillations in LFPs, PAC has become a powerful tool for understanding neural dynamics in both animals and humans. In this work, we introduce a new application for this measure to two LFPs to infer the direction and strength of rhythmic neural transmission between distinct networks. Based on recently accumulating evidence that transmembrane currents related to action potentials contribute a broad-band component to LFP in the high-gamma band, we hypothesized that PAC calculated between high-gamma in one LFP and low-frequency oscillations in another would relate the output (spiking) of one area to the input (soma/dendritic postsynaptic potentials) of the other. We tested this hypothesis on theta-band long range communications between hippocampus and prefrontal cortex (PFC) and theta-band short range communications between different regions within the hippocampus. The results were interpreted within the known anatomical connections predicting hippocampus→PFC and DG→CA3→CA1, i.e., theta transmission is unidirectional in both cases: from hippocampus to PFC and along the tri-synaptic pathway within hippocampus. We found that (1) hippocampal high-gamma amplitude was significantly coupled to theta phase in PFC, but not vice versa; (2) similarly, high-gamma amplitude in DG was significantly coupled to CA1 theta phase, but not vice versa, and (3) the DG high-gamma-CA1 theta PAC was significantly correlated with DG→CA1 Granger causality, a well-established analytical measure of directional neural transmission. These results support the hypothesis that inter-regional PAC (ir-PAC) can be used to relate the output of a “driver” network (i.e., high gamma) to the input of a “receiver” network (i.e., theta) and thereby establish the direction and strength of rhythmic neural transmission.
Intravenous colistin use for infections due to multidrug-resistant gram-negative bacilli in critically ill paediatric patients: a systematic review and meta-analysis
Authors: Karageorgos Spyridon A. , Bassiri Hamid , Siakallis George , Miligkos Michael , Tsioutis Constantinos 
Published: November 2018

SynopsisBackgroundData are limited regarding the clinical effectiveness and safety of intravenous colistin for treatment of infections by multidrug-resistant gram-negative bacilli (MDR-GNB) in the paediatric intensive care unit (PICU).MethodsSystematic review of intravenous colistin use in critically ill paediatric patients with MDR-GNB infection in PubMed, Scopus and Embase (through January 31st, 2018).ResultsOut of 1,181 citations, 7 studies were included on the use of intravenous colistin for 405 patients in PICU. Majority of patients were diagnosed with lower respiratory tract infections, with Acinetobacter baumannii being the predominant pathogen. Colistin dosages ranged between 2.6-18 mg/kg/day, with none but one case reporting a loading dose. Emergence of colistin-resistance during treatment was reported in two cases. Nephrotoxicity and neurotoxicity were reported in 6.1% and 0.5% respectively, but concomitant medications and severe underlying illness limited our ability to definitively associate use of colistin with nephrotoxicity. Crude mortality was 29.5% (95%CI 21.7-38.1%), whereas infection-related mortality was 16.6% (95%CI 12.2-21.5%).ConclusionsWhile the reported incidence of adverse events related to colistin were low, reported mortality rates for infections by MDR-GNB in PICU were notable. In addition to severity of disease and comorbidities, inadequate daily dosage and the absence of a loading dose may have contributed to mortality. As the use of colistin for treatment of MDR-GNB infections increases, it is imperative to understand whether optimal dosing of colistin in paediatric patients differs across different age groups. As such, future studies to establish the pharmacokinetic properties of colistin in different paediatric settings are warranted.
Telomere length, arsenic exposure and risk of basal cell carcinoma of skin
Authors: Srinivas Nalini , Rachakonda Sivaramakrishna , Hielscher Thomas , Calderazzo Silvia , Rudnai Peter , Gurzau Eugen , Koppova Kvetoslava , Fletcher Tony , Kumar Rajiv 
Published: November 2018

AbstractTelomere lengthper sea heritable trait has been reported to be associated with different diseases including cancers. In this study based on arsenic exposed 528 cases with basal cell carcinoma of skin (BCC) and 533 healthy controls, we observed a statistically significant association between decreased telomere length and increased BCC risk (OR = 5.92, 95% CI = 3.92-9.01,P<0.0001). We also observed that higher arsenic exposure (>1.32 µg/L) was statistically significantly associated with decreased telomere length (β = −0.026, 95% CI = − 0.05-0.003,P= 0.02). The interaction between arsenic exposure and telomere length on BCC risk was statistically significant (P= 0.02). Within each tertile based on arsenic exposure, the individuals with shorter telomeres were at an increased risk of BCC, with highest risk being in the highest exposed group (OR = 16.13, 95% CI = 6.71-40.00,P<0.0001); followed by those in medium exposure group (OR = 5.05, 95% CI = 2.29-10.20,P<0.0001), and low exposure group (OR = 3.44, 95% CI = 1.81-6.54,P= 0.0002). The combined effect of highest arsenic exposure and shortest telomeres on the risk of BCC (OR = 10.56, 95% CI = 5.14-21.70) showed a statistically significant departure from additivity (interaction constant ratio 6.56,P= 0.03). Our results show that in the presence of arsenic exposure, decreased telomere length predisposes individuals to increased risk of BCC, with the effect being synergistic in individuals with highest arsenic exposure and shortest telomeres.