bluuebunny/crossref_metadata_2025_split huggingface dataset:
Telephone consultation in primary care
Authors: Gonzalez Francisco , Cimadevila Blanca , Garcia-Comesaña Julio , Cerqueiro Susana , Andion Eladio , Prado Jorge , Bermudez Jorge , Rubial Felix 
Published: March 2018

Purpose
The purpose of this paper is to describe and analyze a teleconsultation modality based on a simple telephone call, using either landline or mobile phone, made available to more than two million people. Telecommunication systems are an increasingly common feature in modern healthcare. However, making teleconsultations available to the entire population covered by a public health system is a challenging goal.

Design/methodology/approach
This retrospective longitudinal observational study analyzed how this modality was used at the primary care level in Galicia, a region in the Northwest of Spain, in 2014 and 2015, focusing on demand, gender and age preferences, rural vs urban population and efficiency.

Findings
Of 28,472,852 consultations requested in this period, 9.0 percent were telephone consultations. Women requested more telephone consultations (9.9 percent of total consultations) than men (7.7 percent of total consultations). The highest demand occurred for the over 85 age group for both men and women. In both years, 2014 and 2015, the number of telephone consultations per inhabitant was higher in urban (0.53 and 0.69) than in rural areas (0.34 and 0.47). In 10.9 percent of cases, the telephone consultations required further face-to-face consultation.

Originality/value
Conventional voice telephone calls can efficiently replace conventional face-to-face consultations in primary healthcare in roughly 10 percent of cases. Women are more likely than men to use primary care services in both face-to-face and telephone consultation modalities. Public healthcare systems should consider implementing telephone consultations to deliver their services.
Does the business model canvas drive venture success?
Authors: Ladd Ted 
Published: March 2018

Purpose
The purpose of this paper is to explore the efficacy of Osterwalder and Pigneur’s Business Model Canvas for 271 teams competing in a venture pitch competition during a cleantech accelerator program.

Design/methodology/approach
It uses competition results and data from a website used by participants to track their hypothesis construction and testing.

Findings
Teams that used the elements of customer segment, value proposition, key activities or key partnerships performed significantly better in the competition. Yet of all nine elements in the Canvas, only customer segmentation showed a significant linear bivariate correlation between the number of validated hypotheses and performance. Finally, teams that heavily used a triumvirate of elements composed of customer segmentation, value proposition and channel performed two times better than teams that barely used these elements.

Research limitations/implications
The findings of this exploratory analysis imply that the components of a business model that explain and predict early success might be different than those for a more mature firm.

Practical implications
These results suggest that practitioners could improve early performance by narrowing their scrutiny to just the triumvirate, because the Canvas may contain components that are unhelpful for entrepreneurs as they form a business model for their nascent venture.

Originality/value
This paper fills a gap by empirically testing the prediction that application of the Business Model Canvas drives venture success and providing a revise definition for a business model that is more appropriate for start-up ventures.
Towards new coopetition-based business models? The case of Netflix on the French market
Authors: Daidj Nabyla , Egert Charles 
Published: March 2018

PurposeThe purpose of this research paper is to discuss the evolution in business models (BM) of one key player (Netflix) in the French online streaming video services market.Design/methodology/approachThe paper is based on a qualitative approach (Netflix case study based on secondary data) to reduce the gap between theory and business practice.FindingsThrough technological convergence, the movie and video industry has seen dramatic changes in the means of consumption, forcing the traditional media players to evolve and adapt their strategy and BM to face new entrants (mainly IT companies). Coopetitive practices have been developed in spite of a fierce competition in the French market with impact on BM. Netflix is representative of this evolution.Research limitations/implicationsThis qualitative research is based on a case study. The results of a single case study cannot be used to make generalizations. Certainly, this paper represents only a first step. Further research is required in this field.Originality/valueThe originality of this paper is to expand the understanding of BMs by including various strategic and marketing perspectives and analyze the impact of coopetitive practices on the BM of one key player: Netflix.
Holistic performance management of virtual teams in third-party logistics environments
Authors: Eaidgah Youness , Abdekhodaee Amir , Najmi Manoochehr , Arab Maki Alireza 
Published: March 2018

Purpose
The purpose of this paper is to investigate the use of an integrated approach for performance improvement of virtual teams (VTs) in third-party logistics (3PL) through the integration of performance management (PM), visual management (VM) and continuous improvement (CI) initiatives into one coherent system. The paper will also propose a methodological framework to establish such a system. The intended integrated system is called as integrated visual management (IVM) throughout this paper.

Design/methodology/approach
This research is based on a case study that took place in a 3PL context with 19 VTs of different sizes spread across Australia. Many major 3PL companies provide their services either internationally or nationwide and therefore use VTs on a regular basis. The selected company does the same. This case was picked as representative of the many complexities which VTs face in 3PL settings, e.g. geographical and temporal separations; different skill levels within the team and between different team bases; multi-teaming system; high staff turnover; recurring performance problems and firefighting approach to problem-solving; and highly demanding performance requirements from clients. Further, this case study, being of a newly established contract and team, enabled the observation of the team dynamic and complexities from the earliest stages. In addition, as the main author of the paper was part of the managerial layer of the studied VT, this provided it a unique opportunity to escape the usual bureaucracy and rather focus on the research. This study also includes a literature review on VTs along with PM, VM and CI, which comprises IVM.

Findings
It was found that an integrated approach to PM, VM and CI was effective in systematically improving the VT performance. The framework for implementing IVM was productive and enabled to successfully plan and deploy the improvement intentions. Even though the team was highly virtual and encompassed a range of situational challenges, including different skill levels, a multi-teaming system and a high staff turnover, nevertheless, through IVM, the results met and exceeded performance targets on a sustainable base. Inventory record accuracy, dispatch on time, delivery in full on time and dock to stock were improved by 45, 62, 22 and 25 per cent on average, respectively.

Originality/value
The originality of the paper comes from its methodological approach to performance improvement for VTs in 3PL contexts through integrating PM, VM and CI systems into one coherent system, IVM.
Validation of a QuEChERS‐Based Gas Chromatography‐Mass Spectrometry (GC‐MS) Method for Analysis of Phthalate Esters in Grain Sorghum
Authors: Sun Xiaotao , Dong Wei , Liu Miao , Shen Caihong , Zhang Yuyu , Sun Jinyuan , Sun Baoguo , Li Hehe , Chen Feng 
Published: March 2018

AbstractA modified QuEChERS method coupled with gas chromatography‐mass spectrometry (GC‐MS) was developed for analysis of 14 phthalate esters (PAEs) in grain sorghum (GS). Chemical extraction was done with acetonitrile followed by dispersive‐solid phase extraction technique with a mixture of sorbents including primary secondary amine and octadecyl silica. Under the optimized condition, the matrix‐matched calibration curves for all PAEs showed good linear relationship in the concentration range between 5 and 500 μg/L with correlation coefficients (R2) better than 0.99. Mean recoveries were between 82.0% and 120.2% at spiking levels of 0.06, 0.6, and 2.0 mg/kg with RSD of 0.3% to 7.8% (n = 5) for intra‐day precision and 1.2% to 7.6% (n = 5) for inter‐day precision. The LODGS and LOQGS for 14 PAEs were between 0.4 and 10.0 μg/kg and 0.5 and 20.0 μg/kg, respectively. Analysis of 32 commercial GS samples revealed that dimethyl‐, diethyl‐, diisobutyl‐, dibutyl‐, and di‐ (2‐ethylhexyl) phthalate esters were detected in all of the analytes. In addition, content‐color scale model was applied to visualize the concentration differences of PAEs in real GS samples. Principal component analysis of PAEs revealed that the GS samples did not have a distinctive cluster based on their geographic origins. The established method was proven to be simple, accurate, and effective for analysis of PAEs in GS, which might also be applied for analysis of PAEs in other matrices.Practical ApplicationA modified QuEChERS‐based GC‐MS method was developed for the determination of phthalate esters (PAEs) in grain sorghum (GS). The ubiquitous presence of PAEs can migrate into GS. Therefore, evaluation of the total content of PAEs in GS is helpful to understand its impact of overall pollution level on other foods. This study has provided some basic information in terms of the content and contamination of PAEs in GS, which is helpful to establish relevant standards and risk assessment of GS for the government.
Yeast culture dietary supplementation modulates gut microbiota, growth and biochemical parameters of grass carp
Authors: Liu Han , Li Juntao , Guo Xianwu , Liang Yunxiang , Wang Weimin 
Published: March 2018

SummaryGut microbiota contributes positively to the physiology of their host. Some feed additives have been suggested to improve livestock health and stimulate growth performance by modulating gut bacteria species. Here, we fed grass carp with 0 (control), 8% (Treat1), 10% (Treat2), 12% (Treat3) and 16% (Treat4) of yeast culture (YC) for 10 weeks. The gut microbiota was analysed by 16S rRNA gene V3‐4 region via an Illumina MiSeq platform. PCoA test showed that gut bacterial communities in the control and Treat3 formed distinctly separate clusters. Although all the groups shared a large size of OTUs as a core microbiota community, a strong distinction existed at genus level. Treat3 contained the highest proportion of the beneficial bacteria and obviously enhanced the capacity of amino acid, lipid metabolism and digestive system. In addition, Treat3 significantly improved the fish growth and increased the liver and serum T‐SOD activities while dramatically decreased the liver GPT and GOT. Collectively, these findings demonstrate the beneficial effects of YC feeding on gut microbiota, growth and biochemical parameters and Treat3 might be the optimal supplementation amount for grass carp, which opens up the possibility that a new feed additive can be developed for healthy aquaculture.
Impact of salvage treatment modalities in patients with positive FDG‐PET/CT after R‐CHOP chemotherapy for aggressive B‐cell non‐Hodgkin lymphoma
Authors: Chin Vicky , Fulham Michael , Hertzberg Mark , Jackson Michael , Lindeman Robert , Brighton Timothy , Kidson‐Gerber Giselle , Wegner Eva A , Cheung Carol , MacCallum Susan , Williams Janet , Thompson Stephen R 
Published: March 2018

AbstractIntroductionTo compare outcomes of different salvage treatment modalities in patients with aggressive B‐cell non‐Hodgkin lymphoma (NHL) who remain FDG‐PET positive after R‐CHOP chemotherapy. Existing data on these patients with FDG‐PET primary refractory disease are limited.MethodsPatients with diffuse large B‐cell lymphoma or grade 3 follicular lymphoma were retrospectively reviewed from the Prince of Wales Hospital databases. Eligibility criteria were: age≥18 years, treated with R‐CHOP, with positive post‐chemotherapy FDG‐PET. Salvage treatment modalities were: radical radiotherapy (RT, dose≥30 Gy), high dose chemotherapy and autologous stem cell transplant (ASCT), or non‐radical management. Survival was calculated from date of post‐chemotherapy FDG‐PET to last follow‐up.ResultsTwenty‐six patients from 2003–2015 met the inclusion criteria. Median age was 60 (range 19–84). Most had adverse baseline features: 21 (81%) stage III‐IV, 24 (92%) bulky disease and nine (35%) skeletal involvement. Characteristics of PET‐positivity post‐chemotherapy were single site in 16 (62%), sites of prior bulk in 24 of 24, skeletal sites in five of nine, and able to be encompassed by RT in 21 (81%). Salvage treatment was: radical RT in 17 (65%), ASCT in four (15%) and non‐radical in five (20%). Median follow‐up of surviving patients was 31 months. Kaplan–Meier estimates of 3‐year PFS and OS were 41% and 52%, respectively. By salvage modality, 3‐year PFS was 51% for RT, 25% for ASCT and 20% for non‐radical treatment, (P = 0.453); 3‐year OS was respectively 65%, 25% and 40% (P = 0.173).ConclusionPatients with FDG‐PET positive disease after R‐CHOP for aggressive B‐cell NHL are salvageable with radiotherapy.
Diagnostic accuracy of diffusion‐weighted imaging‐ magnetic resonance imaging compared to positron emission tomography/computed tomography in evaluating and assessing pathological response to treatment in adult patients with lymphoma: A systematic review
Authors: Fitzpatrick John J , Ryan Miriam A , Bruzzi John F 
Published: March 2018

SummaryThe use of Positron emission tomography/computerised tomography (PET/CT) is well established in the staging and assessment of treatment response of lymphoma. Recent studies have suggested that whole body diffusion‐weighted imaging –magnetic resonance imaging (WB‐DW‐MRI) may be an alternative to PET/CT in both staging and assessment of treatment response. A systematic review was performed to assess the ability of DW‐MRI in the assessment of treatment response in lymphoma. Pubmed, Medline, Web of Science and Embase databases were queried for studies examining whole body DW‐MRI compared to PET/CT in adult patients using a protocol of search terms. We carried out an extensive assessment of titles, abstracts and full texts of relevant paper as well as quality assessment with the Quality Assessment of Diagnostic Accuracy (QUADAS‐2) tool. Eight studies were found to meet the criteria and were included in our review and analysis. Overall, the quality of studies was found to be moderate, with good inter‐rater agreement (K = 0.74). Data analysis showed that lesion‐based assessment in 5 studies with pooled results had a sensitivity and specificity of 94.7% and 99.3%. Assessment with Cohen's Kappa coefficient showed agreement to be excellent (K = 0.88). Three studies were included for qualitative analysis, two of which showed good equivalence between PET/CT and DW‐MRI. WB‐DWI‐MRI can be considered a sensitive and specific method for assessing treatment response in Lymphoma without the use of ionising radiation or administration of F‐18 Flurodeoxyglucose. Further studies are needed to evaluate the optimum b‐values in assessing treatment response.
Group‐specific environmental sequencing reveals high levels of ecological heterogeneity across the microsporidian radiation
Authors: Williams Bryony A. P. , Hamilton Kristina M. , Jones Meredith D. , Bass David 
Published: March 2018

SummaryThe description of diversity is a key imperative in current biological studies and has been revolutionised by the molecular era that allows easy access to microbial diversity not visible to the naked eye. Broadly targeted SSU rRNA gene amplicon studies of diverse environmental habitats continue to reveal new microbial eukaryotic diversity. However, some eukaryotic lineages, particularly parasites, have divergent SSU sequences, and are therefore undersampled or excluded by the methodologies used for SSU studies. One such group is the Microsporidia, which have particularly divergent SSU sequences and are rarely detected in even large‐scale amplicon studies. This is a serious omission as microsporidia are diverse and important parasites of humans and other animals of socio‐economic importance. Whilst estimates of other microbial diversity are expanding, our knowledge of true microsporidian diversity has remained largely static. In this work, we have combined high throughput sequencing, broad environmental sampling and microsporidian‐specific primers to broaden our understanding of the evolutionary diversity of the Microsporidia. Mapping our new sequences onto a tree of known microsporidian diversity we uncover new diversity across all areas of the microsporidian tree and uncover clades dominated by novel sequences, with no close described relatives.
The effect of Psephodiplosis rubi (Diptera: Cecidomyiidae) leaf galls on the secondary metabolite profiles of two congeneric host plants
Authors: Hall Casey R , Robertson Luke P , Carroll Anthony R , Kitching Roger L 
Published: March 2018

AbstractGalling insects have the unique ability to control the secondary chemistry of their host plants. Galled plant tissue often has higher concentrations of these secondary compounds compared with surrounding plant material. In this study, we used nuclear magnetic resonance (NMR) spectroscopy metabolomics techniques to investigate the effect of galls induced by Psephodiplosis rubi Kolesik, on the profiles of secondary metabolites in its two Rubus host plants in subtropical rainforest. We isolated four triterpenoid compounds from both Rubus species. Concentrations of individual triterpenes were not significantly different in galled and non‐galled leaves; however, the concentration of 2‐oxopolomic acid was significantly negatively correlated with gall abundance. At the interspecific level, non‐galled leaves from both Rubus species were chemically indistinguishable in principal component analysis analyses, while galled leaves showed slight chemical differences. Surprisingly, there was very little difference in metabolic profiles of galled and non‐galled leaves at the intraspecific level. Using NMR, we were able to detect slightly different chemical responses in two congeneric host plant species induced by P. rubi galls. We demonstrate how NMR can be used to detect interspecific chemical differences of plants in ecological studies.
Should I Stay or Should I Go? Leaders, Exile, and the Dilemmas of International Justice
Authors: Krcmaric Daniel 
Published: March 2018

AbstractIn recent years, several oppressive leaders have been arrested and extradited to international courts. What are the consequences of this global justice cascade? I address this question by examining patterns of exile. I show that the justice cascade has a differential effect on leaders based on their culpability (whether they presided over atrocity crimes). In the past, culpable and nonculpable leaders went into exile at virtually identical rates. Today, however, culpable leaders are about six times less likely to flee abroad because exile no longer guarantees a safe retirement. These findings raise stark implications for existing research that debates whether international justice deters atrocities or prolongs conflicts. My results about exiled leaders, I explain, imply that the justice cascade should deter atrocities and prolong conflicts. Thus, instead of debating whether international justice is helpful or harmful, future scholarship should carefully consider the trade‐offs it creates.
Preliminary study of the homologous recombination repair pathway in mouse spermatogonial stem cells
Authors: Le W. , Qi L. , Xu C. , Xiang Z. , Mao Z. , Zhang J. , Xu J. , Wu D. 
Published: March 2018

SummaryThe present study was designed to detect DNA repair response through the homologous recombination pathway in mouse spermatogonial stem cells. Mouse spermatogonial stem cells (mSSCs) were obtained from the adult DBA/2 mouse testes by MACS sorting. mSSCs and mice animals were divided into four groups (30 min, 2, 24 h, control) and treated with ionizing irradiation while the control group received pseudo‐irradiation. Proteins involved in the homologous recombination pathway (γH2AX, ATM, RAD51, CtIP, and RPA2) were assessed in mSSCs both in vitro and in vivo. Moreover, the non‐homologous end‐joining or homologous recombination (NHEJ/HR) reporter plasmids were transfected into mSSCs to assess NHEJ/HR pathway activity after DNA double‐strand break (DSB). γH2AX, a classical DNA DSB marker, was absent in mSSCs both in vivo and in vitro after DSB repair, but was highly expressed in other tissue stem cells. In addition, ATM and phosphorylated ATM (p‐ATM) were involved in DNA damage response (DDR) in mSSCs. p‐ATM foci were overexpressed immediately after irradiation (30 min and 2 h), but gradually decreased over the repair time. The HR pathway‐related proteins, CtIP and RPA2 were negatively regulated after treatment in Western blot (WB). NHEJ/HR reporter plasmid transfection indicated that the HR pathway played a minor role in mSSCs during DDR, consistent with the WB findings. This study demonstrates that mSSCs may have a unique response to DNA damage since crucial proteins involved in HR pathway were negatively regulated after DSB. In addition, the expression level of p‐ATM, but not γH2AX, was increased after DSB, suggesting that DNA damage repair in mSSCs might be a γH2AX‐independent response. Furthermore, the HR pathway may play a minor role during DDR in mSSCs.