bluuebunny/crossref_metadata_2025_split huggingface dataset:
Management of Priapism: A Contemporary Review
Authors: Mishra Kirtishri , Loeb Aram , Bukavina Laura , Baumgarten Adam , Beilan Jonathan , Mendez Melissa , DiGiorgio Lorenzo , Fu Liying , Carrion Rafael 
Published: March 2019

ABSTRACTIntroductionCurrent management of ischemic priapism revolves around 3 principles: resolving the acute event, preserving erectile function, and reducing the risk of future recurrences. Although more conservative management options, such as aspiration, irrigation, and surgical shunts, are effective in many patients, those who are refractory to these interventions or have prolonged priapism may benefit from placement of a penile prosthesis (PP).AimTo provide a comprehensive overview of priapism management, highlight the current literature on the utility of penile implants for refractory priapism, and provide insight from a high-volume center on surgical decision making and technique.MethodsA complete review of the current guidelines and associated literature was performed. Associated algorithms were evaluated, and our experience was overlaid on the data present in the literature.Main Outcome MeasuresThe current management algorithm for priapism was evaluated. Subsequently, the data on acute and delayed PP placement were assessed. Rates of postoperative infection, erectile dysfunction, and patient satisfaction were also examined.ResultsOverall, both delayed and early PP implants are associated with higher rates of failure than routine PP implants. In patients with refractory or prolonged priapism, early implantation may be technically easier, with decreased loss of penile length and associated complications.ConclusionPatients should be evaluated on an individual basis and counseled on the risks and benefits of PP implantation in early and delayed time frames. Although there is no definitive evidence at this time regarding the ideal device or timing of implantation, there are well-established pros and cons of malleable vs inflatable prostheses and of acute vs delayed implantation.
Platelet-Rich Plasma Therapy for Male Sexual Dysfunction: Myth or Reality?
Authors: Epifanova Maya V. , Gvasalia Badri R. , Durashov Maksim A. , Artemenko Sergey A. 
Published: March 2019

ABSTRACTIntroductionPlatelet-rich plasma (PRP) found its use in treating different conditions and diseases, because concentrated plasma PRP consists of many growth factors. Their interaction with surrounding cells, intracellular matrix, and mediators at the site of injection leads to tissue regeneration. Angiogenic, vasculogenic, and regenerative effects of PRP may be used for erectile dysfunction (ED) and Peyronie’s disease (PD) treatment.AimTo present a current data review of preclinical and clinical trials on PRP use for treating ED and PD.MethodsUp-to-date literature on PRP use for ED and PD treatment was analyzed. The search was based on Pubmed, Cochrane Library, clinicaltrials.gov databases, with the following key words: “platelet-rich plasma” and/or “erectile dysfunction” and/or “Peyronie’s disease” and/or “sexual dysfunction.”Main Outcome MeasuresThe main outcome measures for preclinical trials on ED were erectile function, assessed with intracavernous pressure, and pathologic analysis of penile tissue. The main outcome measures for clinical trials on ED included penile duplex Doppler ultrasound scanning and validated questionnaires. The main outcome measures on PD were pathologic analysis of penile tissue for preclinical trials, as well as penile duplex Doppler ultrasound scanning, penile curvature angle measuring, and validated questionnaires for clinical trials.Results4 preclinical and 6 clinical trials were described and analyzed in this article. Limitations for both preclinical and clinical trials included small groups, short follow-up periods, a lack of control groups or groups with placebo, and the lack of quality and quantity analysis of PRP.ConclusionAvailable data show the lack of adverse reactions with PRP treatment. The studies that we found were limited by small groups. This is why the data on safety and effectiveness should be taken carefully. However, it is important to mention that PRP therapy has the potential for treating male sexual dysfunction and may be useful in andrology.
Hegel on Reflection and Reflective Judgement
Authors: Miller Elaine P. 
Published: March 2019

AbstractI examine the relation between logic and nature in terms of ‘reflection’, the word that Hegel uses at the end of theEncyclopaedia Logicto describe the self-sundering or externalization of the idea into nature. Although nominally the term ‘reflection’ seems to denote a uniquely mental process and is often used so by Hegel in his early critique ofReflexionsphilosophie, in his later writings it also has an irreducibly ontological significance. Hegel describes logic's opening-out to nature as a movement of ‘reflection’ [Widerschein] and he follows Kant in describing the shift from the finite to the infinite in the relation between nature and thought as one of reflective judgement. Although Hegel generally considers reflection to be uniquely concerned with finite cognition and the constitution of finite things, I argue that in his embrace of reflective judgement he sees a key role for reflection in the relation of logic, nature and spirit.
The prevalence of antiseptic tolerance genes among staphylococci and enterococci in a pediatric population
Authors: Sommer Lauren M. , Krauss Jennifer L. , Hultén Kristina G. , Dunn James J. , Kaplan Sheldon L. , McNeil J. Chase 
Published: March 2019

AbstractObjective:The smr and qacA/B genes in Staphylococcus aureus confer tolerance to antiseptics and are associated with nosocomial acquisition of infection and underlying medical conditions. Such antiseptic tolerance (AT) genes have also been reported in coagulase-negative staphylococci (CoNS) and enterococci, however, few data are available regarding their prevalence. We sought to describe the frequency of AT genes among bloodstream isolates of S. aureus, CoNS and enterococci at Texas Children’s Hospital (TCH).Methods:Banked CoNS, S. aureus and enterococci isolated from blood cultures collected bewteen October 1, 2016, and October 1, 2017, were obtained from the TCH clinical microbiology laboratory. All isolates underwent polymerase chain reaction (PCR) assay for the qacA/B and smr genes. Medical records were reviewed for all cases.Results:In total, 103 CoNS, 19 Enterococcus spp, and 119 S. aureus isolates were included in the study, and 80.6% of the CoNS possessed at least 1 AT gene compared to 37% of S. aureus and 43.8% of E. faecalis isolates (P < .001). Among CoNS bloodstream isolates, the presence of either AT gene was strongly associated with nosocomial infection (P < .001). The AT genes in S. aureus were associated with nosocomial infection (P = .025) as well as the diagnosis of central-line–associated bloodstream infection (CLABSI; P = .04) and recent hospitalizations (P < .001). We found no correlation with genotypic AT in E. faecalis and any clinical variable we examined.Conclusions:Antiseptic tolerance is common among bloodstream staphylococci and E. faecalis isolates at TCH. Among CoNS, the presence of AT genes is strongly correlated with nosocomial acquisition of infection, consistent with previous studies in S. aureus. These data suggest that the healthcare environment contributes to AT among staphylococci.
Unpredictable homeodynamic and ambient constraints on irrational decision making of aneural and neural foragers
Authors: Clark Kevin B. 
Published: March 2019

AbstractForaging for nutritional sustenance represents common significant learned/heritable survival strategies evolved for phylum-diverse cellular life on Earth. Unicellular aneural to multicellular neural foragers display conserved rational or irrational decision making depending on outcome predictions for noise-susceptible real/illusory homeodynamic and ambient dietary cues. Such context-dependent heuristic-guided foraging enables optimal, suboptimal, or fallacious decisions that drive organismal adaptation, health, longevity, and life history.
Hope, exploration, and equilibrated action schemes
Authors: Gozli Davood G. , Gao Ci Jun 
Published: March 2019

AbstractThe concepts want, hope, and exploration cannot be organized in relation to a single type of motive (e.g., motive for food). They require, in addition, the motive for acquiring and maintaining a stable scheme that enables reward-directed activity. Facing unpredictability, the animal has to seek not only reward, but also a new equilibrated state within which reward seeking is possible.
Does the “incentive hope” hypothesis explain food-wasting behavior among humans? Yes and no
Authors: Misiak Michał , Sorokowski Piotr , Karwowski Maciej 
Published: March 2019

AbstractIn this commentary, we discuss how the “incentive hope” hypothesis explains differences in food-wasting behaviors among humans. We stress that the role of relevant ecological characteristics should be taken into consideration together with the incentive hope hypothesis: population mobility, animal domestication, and food-wasting visibility.
Household composition and the dynamics of community-based social care in England
Authors: Iparraguirre José 
Published: March 2019

AbstractLittle is known about the dynamic relationship between the different funding sources of community-based social care in England. Using Waves 2–6 (2004–2013) of the English Longitudinal Study of Ageing survey, I estimated dynamic multi-level cross-classified mixed-effects logistic regression models to investigate whether receiving services by one source is more or less likely if an older person was already receiving services funded by the same source or another in the previous period. Four hypotheses between formal privately and publicly funded help and informal help are tested: substitution, complementarity, compensation and task-specificity. I also report evidence that older people on low incomes residing in local authorities that reduce social care spending are especially affected.
‘That's for old so and so's!’: does identity influence older adults’ technology adoption decisions?
Authors: Astell Arlene J. , McGrath Colleen , Dove Erica 
Published: March 2019

AbstractThe role of identity in older adults’ decision-making about assistive technology adoption has been suggested but not fully explored. This scoping review was conducted to understand better how older adults’ self-image and their desire to maintain this influence their decision-making processes regarding assistive technology adoption. Using the five-stage scoping review framework by Arksey and O'Malley, a total of 416 search combinations were run across nine databases, resulting in a final yield of 49 articles. From these 49 articles, five themes emerged: (a) resisting the negative reality of an ageing and/or disabled identity; (b) independence and control are key; (c) the aesthetic dimension of usability; (d) assistive technology as a last resort; and (e) privacy versus pragmatics. The findings highlight the importance of older adults’ desire to portray an identity consistent with independence, self-reliance and competence, and how this desire directly impacts their assistive technology decision-making adoption patterns. These findings aim to support the adoption of assistive technologies by older adults to facilitate engagement in meaningful activities, enable social participation within the community, and promote health and wellbeing in later life.
Coriolis force-assisted inertial confinement fusion
Authors: Winterberg F. 
Published: March 2019

AbstractA fundamental problem for the realization of laser fusion through the implosion of a spherical target is Kidder's E−1/6 law, where E is the energy needed for ignition, proportional to the 6th power of the ratio R/R0, where R0 and R are the initial and final implosion radii, respectively. This law implies that the ignition energy is very sensitive to the ratio R0/R, or vice versa, the ratio R0/R is very insensitive to the energy input, with R0/R limited by the Rayleigh–Taylor instability. According to still classified data of the Centurion–Halite experiment at the Nevada Test Site, ignition would require an energy of ${\rm E}\simeq 50\,{\rm MJ}$, 25 times larger than the 2 MJ laser at the National Ignition Facility (NIF) reported in the New York Times. This means that even a tenfold increase from 2 to 20 MJ would only decrease the R/R0 ratio by an insignificant factor of 10−1/6 ≃ 0.7. To overcome this problem, it is proposed that the spherical target is replaced with a hollowed-out, rapidly rotating, cm-size ferromagnetic target, accelerated by a rotating traveling magnetic wave to a rotational velocity of ~1 km/s, at the limit of its tensile strength. In a rotating reference system, the general theory of relativity predicts the occurrence of negative gravitational field masses in the center of rotation, with their source located in the Coriolis force field. The density of this negative gravitational field mass can be larger than the magnitude of the positive mass density of a neutron star. The repulsive gravitational force causes the centrifugal force. For a magnetized plasma placed in the rapidly spinning, hollowed-out target chamber, this repulsive force can be balanced by the magnetic force generated by thermomagnetic currents of the Nernst effect. Such a configuration does not suffer from the Rayleigh–Taylor instability, but becomes a small magnetohydrodynamic generator, amplifying the magnetic field to values about equal to those of the Nernst effect, axially confining the plasma. By placing the spinning target in the center of a lithium vortex, the fusion neutrons absorbed in the vortex can breed tritium, and at the same time remove heat from the target chamber to sustain the Nernst effect. A hot spot is thereby produced in the target chamber, which launches a thermonuclear burn wave into a cylindrical deuterium–tritium configuration. With the stability of a rapidly rotating target greatly increased, and the range of 10 MeV electrons in the wall of the cm-size ferromagnetic target, an intense 10 MeV relativistic electron beam drawn from a 10 MJ Marx generator should be sufficient to implode the target for thermonuclear ignition.
Surgery-induced cryptorchidism induces apoptosis and autophagy of spermatogenic cells in mice
Authors: Zheng Yi , Zhang Pengfei , Zhang Conghui , Zeng Wenxian 
Published: March 2019

SummaryCryptorchidism, characterized by the presence of one (unilateral) or both (bilateral) undescended testes, is a common male urogenital defect. Cryptorchidism can lead to male infertility, testicular cancer being the most extreme clinical symptom, as well as psychological issues of the inflicted individual. Despite this, both knowledge about the aetiology of cryptorchidism and the mechanism for cryptorchidism-induced male infertility remain limited. In this present study, by using an artificial cryptorchid mouse model, we investigated the effects of surgery-induced cryptorchidism on spermatogenic cells and seminiferous epithelial cycles. We found that surgery-induced cryptorchidism led to a reduced testicular weight, aberrant seminiferous epithelial cycles and impaired spermatogenesis characterized by degenerating spermatogenic cells. We also observed multinucleated giant cells after surgery-induced cryptorchidism. Transmission electron microscopy, terminal deoxynucleotidyl transferase dUTP nick end labelling (TUNEL) and western blot assays demonstrated cryptorchidism-induced apoptosis of spermatogenic cells. Moreover, we identified the occurrence of autophagy in germ cells after surgery-induced cryptorchidism. Interestingly, apoptosis and autophagy were synchronous, suggestive of their synergetic roles in promoting germ cell death. Our results provide novel insights into the cryptorchidism-induced male infertility, thereby contributing to the development of male contraceptive strategies as well as treatment options for male infertility caused by cryptorchidism.
Ingredient bundles and recipe tastings in food pantries: a pilot study to increase the selection of healthy foods
Authors: Stein Emma C , Stowers Kristen Cooksey , McCabe Michelle L , White Marney A , Schwartz Marlene B 
Published: March 2019

AbstractObjectiveThe present study examined the effect of ingredient bundles (i.e. measured ingredients with recipes) and recipe tastings as a strategy to increase the selection of healthy, target foods (kale, brown rice and whole-wheat pasta).DesignEach of the three conditions was tested once per week for three weeks. The conditions were: Treatment 1 (T1), recipe tastings only; Treatment 2 (T2), ingredient bundle plus recipe tastings; and Control, no intervention.SettingA food pantry in Bridgeport, CT, USA.ParticipantsFood pantry clients.ResultsControlling for family size and intervention week, the likelihood of clients in T2 (n 160) selecting at least one target item compared with the Control group (n 160) was 3·20 times higher for kale, 4·76 times higher for brown rice and 7·25 times higher for whole-wheat pasta. Compared with T1 (n 128), T2 clients were 2·67 times more likely to select kale, 7·67 times more likely to select brown rice and 11·43 times more likely to select whole-wheat pasta. No differences between T1 and the Control group were found.ConclusionsFindings suggest that innovative, nudging strategies such as ingredient bundles may increase appeal of foods and encourage pantry clients to select healthier options.
Melt-water formed dark streaks on slopes of Haughton crater as possible Mars analogues
Authors: Clarke Jonathan , Knightly Paul , Rupert Shannon 
Published: March 2019

AbstractHaughton crater in the Canadian Arctic has been extensively used as a Mars (and lunar) analogue over the past 20 years. Here we report on small scale, dark, semi-seasonal slope streaks formed by melt water flowing down the crater walls that we observed during the Mars Society-sponsored M160 expedition to the F-MARS facility on the NW rim of the crater. The streaks are formed by biofilms colonizing snow melt flowing from semi-permanent snow patches in Haughton crater on Devon Island and elsewhere in the Canadian Arctic. These features superficially resemble the dark slope streaks and recurring slope lineae (RSL) observed on Mars and may serve as analogues for wet models for their formation and a contrast with dry formation models. Their significance to astrobiology and planetary science is three-fold: (1) as examples of dark recurring streaks known to be associated with water they provide a benchmark to compare with Martian slope streaks and RSL. (2) The melt streaks may have potential as astrobiological analogues for wet models of slope streaks and RSL. (3) They are natural laboratories to study planetary protection issues associated with robotic and astronaut exploration of potential water-related slope features on Mars.
Paleometry as a key tool to deal with paleobiological and astrobiological issues: some contributions and reflections on the Brazilian fossil record
Authors: Gomes Amanda L. S. , Becker-Kerber Bruno , Osés Gabriel L. , Prado Gustavo , Becker Kerber Pedro , de Barros Gabriel E. B. , Galante Douglas , Rangel Elidiane , Bidola Pidassa , Herzen Julia , Pfeiffer Franz , Rizzutto Márcia A. , Pacheco Mírian L. A. F. 
Published: March 2019

AbstractInvestigations into the existence of life in other parts of the cosmos find strong parallels with studies of the origin and evolution of life on our own planet. In this way, astrobiology and paleobiology are married by their common interest in disentangling the interconnections between life and the surrounding environment. In this way, a cross-point of both sciences is paleometry, which involves a myriad of imaging and geochemical techniques, usually non-destructive, applied to the investigation of the fossil record. In the last decades, paleometry has benefited from an unprecedented technological improvement, thus solving old questions and raising new ones. This advance has been paralleled by conceptual approaches and discoveries fuelled by technological evolution in astrobiological research. In this context, we present some new data and review recent advances on the employment of paleometry to investigations on paleobiology and astrobiology in Brazil in areas such biosignatures in Ediacaran microbial mats, biogenicity tests on enigmatic Ediacaran structures, research on Ediacaran metazoan biomineralization, fossil preservation in Cretaceous insects and fish, and finally the experimental study on the decay of fish to test the effect of distinct types of sediment on soft-tissue preservation, as well as the effects of early diagenesis on fish bone preservation.
Measurement of Hedonic and Eudaimonic Orientations to Happiness: The Spanish Orientations to Happiness Scale
Authors: Lorente Laura , Tordera Núria , Peiró José María 
Published: March 2019

AbstractUnderstanding happiness and well-being has been one of the central issues for psychologists in recent decades. Happiness orientations have been identified as important pathways toward different types of well-being, and so the development and validation of scales for their measurement is an important step in their study. The present research aims to adapt and validate the Spanish Orientations to Happiness Scale (SOTH), a 6-item scale based on the Orientations to Happiness Questionnaire. This brief scale, which measures hedonic and eudemonic orientations, was administered to 1,647 Spanish workers. Scale structure was subjected to exploratory (EFA) and confirmatory (CFA) factor analysis to obtain evidence of factorial validity. Evidence for convergent validity was assessed by correlating the scale with two measures of hedonic and eudaimonic well-being, and discriminant validity was assessed with the average variance extracted (AVE). Results of EFA showed a two-factor solution, and CFA partially supported this structure, χ2(8,N= 793) = 36.61, p < .001; RMSEA = .06; SRMR = .05; CFI = .97; ACFI = .96. Results also demonstrated appropriate convergent and discriminant validity. The SOTH Scale has been shown to be reliable (CR indices > .72) and valid (AVE = .50), and so it is a valuable tool for assessing orientations to happiness in the Spanish context. Finally, the scientific value and practical utility of the scale are discussed.
Quantifying the Impact of Atmospheric Transport Uncertainty on CO2 Surface Flux Estimates
Authors: Schuh Andrew E. , Jacobson Andrew R. , Basu Sourish , Weir Brad , Baker David , Bowman Kevin , Chevallier Frédéric , Crowell Sean , Davis Kenneth J. , Deng Feng , Denning Scott , Feng Liang , Jones Dylan , Liu Junjie , Palmer Paul I. 
Published: March 2019

We show that transport differences between two commonly used global chemical transport models, GEOS‐Chem and TM5, lead to systematic space‐time differences in modeled distributions of carbon dioxide and sulfur hexafluoride. The distribution of differences suggests inconsistencies between the transport simulated by the models, most likely due to the representation of vertical motion. We further demonstrate that these transport differences result in systematic differences in surface CO2 flux estimated by a collection of global atmospheric inverse models using TM5 and GEOS‐Chem and constrained by in situ and satellite observations. While the impact on inferred surface fluxes is most easily illustrated in the magnitude of the seasonal cycle of surface CO2 exchange, it is the annual carbon budgets that are particularly relevant for carbon cycle science and policy. We show that inverse model flux estimates for large zonal bands can have systematic biases of up to 1.7 PgC/year due to large‐scale transport uncertainty. These uncertainties will propagate directly into analysis of the annual meridional CO2 flux gradient between the tropics and northern midlatitudes, a key metric for understanding the location, and more importantly the processes, responsible for the annual global carbon sink. The research suggests that variability among transport models remains the largest source of uncertainty across global flux inversion systems and highlights the importance both of using model ensembles and of using independent constraints to evaluate simulated transport.