bluuebunny/crossref_metadata_2025_split huggingface dataset:
Les impacts du vieillissement de la population française sur les systèmes sanitaires et médico-sociaux : une analyse des revues académiques et professionnelles depuis la loi ASV
Authors: Hentic-Giliberto Michelle , Stephan Sylvie 
Published: February 2019

La loi d’Adaptation de la Société au Vieillissement (ASV), promulguée en décembre 2015, fait de la prise en compte du vieillissement « un impératif national et une priorité de l’ensemble des politiques publiques de la nation ». Le présent article vise à nourrir l’état des lieux de la prise en compte de cette problématique, au moyen d’une étude du contenu éditorial de la littérature académique et professionnelle francophone. La recherche porte sur deux corpus , l’un extrait du portail de sciences humaines et sociales de langue française CAIRN.INFO, l’autre constitué de 330 articles issus de revues du secteur sanitaire et médico-social sur la période allant de janvier 2015 à mai 2018. Une démarche exploratoire fondée sur une analyse lexicale permet d’extraire des contenus, l’approche du vieillissement telle qu’elle est abordée dans les travaux académiques en SHS et spécifiquement en économie-gestion, et dans les revues professionnelles du secteur sanitaire et médico-social. Une étude approfondie est menée sur les trois thématiques que sont la gouvernance du système de santé, le management des structures sanitaires et médico-sociales, la silver économie. Les résultats font apparaître que si la sociologie est la discipline qui étudie de manière plus marquée l’émergence et les conséquences du vieillissement sur l’environnement et les populations (66 articles), seuls 28 articles en sciences économiques et sciences de gestion lui sont consacrés. Ces derniers identifient principalement la problématique de la gouvernance du vieillissement au niveau macro-économique ou en lien avec les situations particulières de certains pays. Seuls, quelques rares articles s’intéressent spécifiquement à la situation française et aux dimensions managériale, organisationnelle ou opérationnelle. Concernant les revues professionnelles, l’accent est mis sur le positionnement de la personne âgée au cœur du dispositif d’accompagnement, les thématiques de la dépendance et des domaines et modalités de sa prise en charge sont largement discutées. De part et d’autre la silver économie, pourtant identifiée comme un véritable levier de croissance (OMS 2 , 2016), reste mal identifiée.
Une pensée inutile
Authors: Maffesoli Michel 
Published: February 2019

Dans la lignée de penseurs trop délaissés, tels Goerges Bataille, Georg Simmel, l’auteur tente de montrer comment il y a un « hédonisme du quotidien » qui sous-tend toute vie en société. Non plus une attente, une tension vers l’avenir, mais un présentéisme. On voit resurgir ce que Bataille nommait la « part maudite », cet aspect chtonien, nocturne de l’imaginaire. Le lien social devient émotionnel. Ce que l’auteur nomme « une éthique de l’esthétique ».
La part de l’autre. Georges Bataille, notre prochain
Authors: Tacussel Patrick 
Published: February 2019

L’objectif de cet article est de mettre en relief la force de la pensée radicale de Georges Bataille par la mise en perspective des multiples aspects de son œuvre explorant les arcanes de la société. L’accent est mis sur une expérience intérieure conçue comme fil conducteur nous amenant à une compréhension de l’hétérogénéité du social via la transgression, l’énergie, la dépense : en somme une exploration de la vie dans toute sa puissance.
La politique d’éros comme volonté de chance
Authors: Christias Panagiotis 
Published: February 2019

À partir de l’ouvrage	Sur Nietzsche de Georges Bataille, l’auteur pointe la mise en jeu de la chance en tant que donnée du monde. La problématique théorique est fondée sur une « expérience intérieure » qui met en scène un sujet désirant cette existence de la chance, alors qu’elle suscite en même temps une part d’angoisse et qu’elle met également en question la raison et l’autre.
Laure. Le démon de la curiosité et ses échos
Authors: Chiore Valeria 
Published: February 2019

La réflexion porte ici sur la figure de Colette Peignot, dite Laure, au centre d’un cercle englobant Nietzsche, Lautréamont, Klossowski et bien sûr Bataille, pour lequel elle fut une muse inspiratrice. Ses écrits sont une sorte de kaléidoscope dans lequel on peut percevoir la force d’écrire et celle de lire. L’attention est portée sur les textes posthumes	Histoire d’une petite fille et	Le sacré , afin d’en saisir les images, émotions et réflexions qui ont particulièrement irradié Georges Bataille, tant dans sa vie que dans son œuvre.
Les Trente sans gloire vues par l’œil de Bataille
Authors: Romano Onofrio 
Published: February 2019

La pensée de Georges Bataille est toujours d’actualité et nous aide à interroger notre présent. L’objectif de cet article consiste à proposer une compréhension des	trente sans gloire du néo-libéralisme sous l’angle de la souveraineté, de la dépense et de l’excédent d’énergie dont les effets sur le sujet contemporain sont manifestes, en inaugurant en définitive une possible construction sociale de la conscience de soi.
A Dedicated Fracture Reduction Room: A Cost-Effective Alternative to the Operating Room
Authors: Whitlock Patrick W. , Little Kevin J. , Singleton Sandra S. , Mahmoud Mohamed , Ngamprasertwong Pornswan , McCarthy James J. 
Published: February 2019

Introduction:
Charges, procedural efficiency, return to activity, and complications after closed treatment of fractures performed in an operating room (OR) versus closed reduction in a dedicated fracture reduction room (FRR) were compared.

Methods:
Patients with closed fractures of the forearm who underwent closed reduction in the year before (OR), and after implementation of the FRR, were retrospectively reviewed. Charges, American Society of Anesthesiologists class, sex, age, length of follow-up, prior reduction, fracture location/displacement, time from injury to procedure, procedural time, time to return to activity, and complications were recorded.

Results:
Eighteen patients met the inclusion criteria in the FRR group (13 men, 5 women), and 22 in the OR group (18 men, 4 women). No notable differences in age, sex, follow-up, American Society of Anesthesiologists class, fracture location/displacement, incidence of prior reduction, or time to return to activity were observed. Two (9.5%) complications occurred in the FRR group versus 7 (32%) in the OR group, P > 0.05. No anesthesia complications were present. Patients treated in the FRR incurred charges of $5,299 ± $1,289 versus $10,455 ± $2,290 in the OR, P < 0.001. Total time of visit in the FRR was ∼30% less than the OR, P < 0.001. No notable delay in treatment was observed.

Discussion:
In the era of finite resources and value-based care, implementation of a FRR resulted in safe, cost-effective, and increased procedural efficiency.
Simultaneous Analysis of Iodine and Bromine Species in Infant Formula using HPLC-ICP-MS
Authors: Nelson Jenny , Pacquette Lawrence , Dong Shuofei , Yamanaka Michiko 
Published: February 2019

Abstract
Background: A fast and sensitive method for the simultaneous analysis of iodine and bromine species in infant formula was developed using HPLC–inductively coupled plasma–MS (HPLC-ICP-MS). Method: To determine the four halogen species [iodide (I−), iodate &lt;inline-formula&gt;&lt;mml:math display="inline"&gt;&lt;mml:mrow&gt;&lt;mml:mo&gt;(&lt;/mml:mo&gt;&lt;mml:mrow&gt;&lt;mml:msubsup&gt;&lt;mml:mrow&gt;&lt;mml:mi mathvariant="normal"&gt;IO&lt;/mml:mi&gt;&lt;/mml:mrow&gt;&lt;mml:mn&gt;3&lt;/mml:mn&gt;&lt;mml:mo&gt;−&lt;/mml:mo&gt;&lt;/mml:msubsup&gt;&lt;/mml:mrow&gt;&lt;mml:mo&gt;)&lt;/mml:mo&gt;&lt;/mml:mrow&gt;&lt;/mml:math&gt;&lt;/inline-formula&gt;, bromide (Br−), and bromate &lt;inline-formula&gt;&lt;mml:math display="inline"&gt;&lt;mml:mrow&gt;&lt;mml:mo&gt;(&lt;/mml:mo&gt;&lt;mml:mrow&gt;&lt;mml:msubsup&gt;&lt;mml:mrow&gt;&lt;mml:mi mathvariant="normal"&gt;BrO&lt;/mml:mi&gt;&lt;/mml:mrow&gt;&lt;mml:mn&gt;3&lt;/mml:mn&gt;&lt;mml:mo&gt;−&lt;/mml:mo&gt;&lt;/mml:msubsup&gt;&lt;/mml:mrow&gt;&lt;mml:mo&gt;)&lt;/mml:mo&gt;&lt;/mml:mrow&gt;&lt;/mml:math&gt;&lt;/inline-formula&gt;] in a milk-based Standard Reference Material and four commercially available infant formula products. Results: The four halogen species were baseline separated in less than 6.5 min using an anion exchange resin column and 5.0 mM NaH2PO4 / 15.0 mM Na2SO4 / 5.0 mM EDTA (pH 7.0) mobile phase. Following separation, the halogen species were detected by measuring m/z 79 for Br and m/z 127 for I using a triple quadrupole–ICP-MS. The instrument was operated in single quadrupole mode with helium cell gas. Excellent linearity (R = 0.9999 or better) was obtained for all four species with calibration standards ranging from 0 to 100 ppb. The LOD for I−, &lt;inline-formula&gt;&lt;mml:math display="inline"&gt;&lt;mml:msubsup&gt;&lt;mml:mrow&gt;&lt;mml:mi mathvariant="normal"&gt;IO&lt;/mml:mi&gt;&lt;/mml:mrow&gt;&lt;mml:mn&gt;3&lt;/mml:mn&gt;&lt;mml:mo&gt;−&lt;/mml:mo&gt;&lt;/mml:msubsup&gt;&lt;/mml:math&gt;&lt;/inline-formula&gt;, Br−, and &lt;inline-formula&gt;&lt;mml:math display="inline"&gt;&lt;mml:msubsup&gt;&lt;mml:mrow&gt;&lt;mml:mi mathvariant="normal"&gt;BrO&lt;/mml:mi&gt;&lt;/mml:mrow&gt;&lt;mml:mn&gt;3&lt;/mml:mn&gt;&lt;mml:mo&gt;−&lt;/mml:mo&gt;&lt;/mml:msubsup&gt;&lt;/mml:math&gt;&lt;/inline-formula&gt; were all less than 0.67 μg/kg. To test the suitability of the method for the accurate determination of low concentrations of the four species in infant formula samples, a spike recovery test was carried out at 20 and 40 μg/kg into the diluted infant formula samples. Conclusions: Total elemental determinations of iodine and bromine were also performed using the triple quadrupole–ICP-MS without HPLC.
Threshold value and applicable range of nonlinear behavior detection method using second derivative of acceleration
Authors: Iyama Jun , Wakui Masaki 
Published: February 2019

AbstractA previously proposed nonlinearity detection method using the second derivative “snap” of the recorded absolute acceleration requires the determination of a threshold value based on the yield strength of the target vibration system, which may not be known. Therefore, this study aims to extend this detection method by determining the mathematical relation between the snap and stiffness change and velocity of the vibration system; the results indicate that the threshold value required to detect nonlinearities can be explicitly expressed by mathematical equations. Although the accuracy of this detection method is affected by the intensity of noise and the time intervals of the acceleration records, the introduced mathematical model can both explain these effects and allow the user to decide a priori whether this method can be used to detect nonlinearities. Furthermore, the proposed mathematical model for nonlinearity detection was verified by dynamic response analysis with varying natural periods, showing that the detectable range estimated by the model agreed with the range where the accuracy of nonlinearity detection by snap increases.
Substituent Position‐Controlled Stereoselectivity in Enzymatic Reduction of Diaryl‐ and Aryl(heteroaryl)methanones
Authors: Li Zhining , Wang Zexu , Wang Yuhan , Wu Xiaofan , Lu Hong , Huang Zedu , Chen Fener 
Published: February 2019

AbstractWe report here the discovery of a novel ketoreductase (KRED), named KmCR2, with a broad substrate spectrum on bioreduction of sterically bulky diaryl‐ and aryl(heteroaryl)methanones. The position of the substituent on aromatic rings (meta versus para or ortho) was revealed to control the stereospecificity of KmCR2. The stereoselective preparation of both enantiomers of diaryl‐ or aryl(heteroaryl)methanols using strategically engineered substrates with a traceless directing group (bromo group) showcased the potential application of this substrate‐controlled bioreduction reaction. The combined use of substrate engineering and protein engineering, was demonstrated to be a useful strategy in efficiently improving stereoselectivity or switching stereopreference of enzymatic processes.magnified image
Synthesis of Redox‐switchable 5,15‐Dialkyl‐10,20‐diaryl‐5,15‐diazaporphyrins and Diversification of their N‐Alkyl Groups
Authors: Mutoh Mai , Sudoh Keisuke , Furukawa Ko , Minoura Mao , Nakano Haruyuki , Matano Yoshihiro 
Published: February 2019

AbstractNickel(II) and copper(II) complexes of redox‐switchable 20π, 19π, and 18π 5,15‐dialkyl‐10,20‐diaryl‐5,15‐diazaporphyrins were prepared through a metal‐templated cyclization method. Furthermore, the terminal silyloxy groups in the peripheral N‐alkyl chains were transformed into hydroxy groups by deprotection. It is worth noting that redox reactions between the 19π and 18π systems bearing hydroxy groups caused a change in the water solubility of the diazaporphyrin chromophore.
Skin nerve pathology: Biomarkers of premanifest and manifest amyloid neuropathy
Authors: Chao Chi‐Chao , Hsueh Hsueh‐Wen , Kan Hung‐Wei , Liao Chun‐Hua , Jiang Hao‐Hua , Chiang Hao , Lin Whei‐Min , Yeh Ti‐Yen , Lin Yea‐Huey , Cheng Ya‐Yin , Hsieh Sung‐Tsang 
Published: February 2019

ObjectiveSmall‐fiber sensory and autonomic symptoms are early presentations of familial amyloid polyneuropathy (FAP) with transthyretin (TTR) mutations. This study aimed to explore the potential of skin nerve pathologies as early and disease‐progression biomarkers and their relationship with skin amyloid deposits.MethodsSkin biopsies were performed in patients and carriers to measure intraepidermal nerve fiber (IENF) density, sweat gland innervation index of structural protein gene product 9.5 (SGII[PGP9.5]) and peptidergic vasoactive intestinal peptide (SGII[VIP]), and cutaneous amyloid index. These skin pathologies were analyzed with clinical disability assessed by FAP stage score (stage 0–4) and compared to neurophysiological and psychophysical tests.ResultsThere were 70 TTR‐mutant subjects (22 carriers and 48 patients), and 66 cases were TTR‐A97S. Skin nerve pathologies were distinct according to stage. In carriers, both skin denervation and peptidergic sudomotor denervation were evident: (1) IENF density was gradually reduced from stage 0 through 4, and (2) SGII(VIP) was markedly reduced from stage 1 to 2. In contrast, SGII(PGP9.5) was similar between carriers and controls, but it declined in patients from stage 2. Skin amyloids were absent in carriers and became detectable from stage 1. Cutaneous amyloid index was correlated with SGII(PGP9.5) and stage in a multivariate mixed‐effect model. When all tests were compared, only IENF density, SGII(PGP9.5), and cutaneous amyloid index were correlated with stage, and IENF density had the highest abnormal rate in carriers.InterpretationBiomarkers of sensory and sudomotor innervation exhibited a stage‐dependent progression pattern, with sensory nerve degeneration as the early skin nerve pathology. Ann Neurol 2019;85:560–573
The siRNAsome: A Cation‐Free and Versatile Nanostructure for siRNA and Drug Co‐delivery
Authors: Zheng Meng , Jiang Tong , Yang Wen , Zou Yan , Wu Haigang , Liu Xiuhua , Zhu Fengping , Qian Rongjun , Ling Daishun , McDonald Kerrie , Shi Jinjun , Shi Bingyang 
Published: February 2019

AbstractNanoparticles show great potential for drug delivery. However, suitable nanostructures capable of loading a range of drugs together with the co‐delivery of siRNAs, which avoid the problem of cation‐associated cytotoxicity, are lacking. Herein, we report an small interfering RNA (siRNA)‐based vesicle (siRNAsome), which consists of a hydrophilic siRNA shell, a thermal‐ and intracellular‐reduction‐sensitive hydrophobic median layer, and an empty aqueous interior that meets this need. The siRNAsome can serve as a versatile nanostructure to load drug agents with divergent chemical properties, therapeutic proteins as well as co‐delivering immobilized siRNAs without transfection agents. Importantly, the inherent thermal/reduction‐responsiveness enables controlled drug loading and release. When siRNAsomes are loaded with the hydrophilic drug doxorubicin hydrochloride and anti‐P‐glycoprotein siRNA, synergistic therapeutic activity is achieved in multidrug resistant cancer cells and a tumor model.
Oxygen Evolution Reaction over the Au/YSZ Interface at High Temperature
Authors: Song Yuefeng , Zhou Si , Dong Qiao , Li Yangsheng , Zhang Xiaomin , Ta Na , Liu Zhi , Zhao Jijun , Yang Fan , Wang Guoxiong , Bao Xinhe 
Published: February 2019

AbstractThe oxygen evolution reaction (OER) is a sluggish electrocatalytic reaction in solid oxide electrolysis cells (SOECs) at high temperatures (600–850 °C). Perovskite oxide has been widely investigated for catalyzing the OER; however, the formation of cation‐enriched secondary phases at the oxide/oxide interface blocks the active sites and decreases OER performance. Herein, we show that the Au/yttria‐stabilized zirconia (YSZ) interface possesses much higher OER activity than the lanthanum strontium manganite/YSZ anode. Electrochemical characterization and density functional theory calculations suggest that the Au/YSZ interface provides a favorable path for OER by triggering interfacial oxygen spillover from the YSZ to the Au surface. In situ X‐ray photoelectron spectroscopy results confirm the existence of spillover oxygen on the Au surface. This study demonstrates that the Au/YSZ interface possesses excellent catalytic activity for OER at high temperatures in SOECs.
Solid Base Bi24O31Br10(OH)δ with Active Lattice Oxygen for the Efficient Photo‐Oxidation of Primary Alcohols to Aldehydes
Authors: Dai Yitao , Ren Pengju , Li Yaru , Lv Dongdong , Shen Yanbin , Li Yongwang , Niemantsverdriet Hans , Besenbacher Flemming , Xiang Hongwei , Hao Weichang , Lock Nina , Wen Xiaodong , Lewis James P. , Su Ren 
Published: February 2019

AbstractThe selective oxidation of primary alcohols to aldehydes by O2 instead of stoichiometric oxidants (for example, MnVII, CrVI, and OsIV) is an important but challenging process. Most heterogeneous catalytic systems (thermal and photocatalysis) require noble metals or harsh reaction conditions. Here we show that the Bi24O31Br10(OH)δ photocatalyst is very efficient in the selective oxidation of a series of aliphatic (carbon chain from C1 to C10) and aromatic alcohols to their corresponding aldehydes/ketones under visible‐light irradiation in air at room temperature, which would be challenging for conventional thermal and light‐driven processes. High quantum efficiencies (71 % and 55 % under 410 and 450 nm irradiation) are reached in a representative reaction, the oxidation of isopropanol. We propose that the outstanding performance of the Bi24O31Br10(OH)δ photocatalyst is associated with basic surface sites and active lattice oxygen that boost the dehydrogenation step in the photo‐oxidation of alcohols.
Photoinduced Reversible Solid‐to‐Liquid Transitions for Photoswitchable Materials
Authors: Xu Wen‐Cong , Sun Shaodong , Wu Si 
Published: February 2019

AbstractHeating and cooling can induce reversible solid‐to‐liquid transitions of matter. In contrast, athermal photochemical processes can induce reversible solid‐to‐liquid transitions of some newly developed azobenzene compounds. Azobenzene is photoswitchable. UV light induces trans‐to‐cis isomerization; visible light or heat induces cis‐to‐trans isomerization. Trans and cis isomers usually have different melting points (Tm) or glass transition temperatures (Tg). If Tm or Tg of an azobenzene compound in trans and cis forms are above and below room temperature, respectively, light may induce reversible solid‐to‐liquid transitions. In this Review, we introduce azobenzene compounds that exhibit photoinduced reversible solid‐to‐liquid transitions, discuss the mechanisms and design principles, and show their potential applications in healable coatings, adhesives, transfer printing, lithography, actuators, fuels, and gas separation. Finally, we discuss remaining challenges in this field.
Cetacean Skull Telescoping Brings Evolution of Cranial Sutures into Focus
Authors: Roston Rachel A. , Roth V. Louise 
Published: February 2019

ABSTRACTMany modifications to the mammalian bauplan associated with the obligate aquatic lives of cetaceans—fusiform bodies, flukes, flippers, and blowholes—are evident at a glance. But among the most strikingly unusual and divergent features of modern cetacean anatomy are the arrangements of their cranial bones: (1) bones that are situated at opposite ends of the skull in other mammals are positioned close together, their proximity resulting from (2) these bones extensively overlapping the bones that ordinarily would separate them. The term “telescoping” is commonly used to describe the odd anatomy of modern cetacean skulls, yet its usage and the particular skull features to which it refers vary widely. Placing the term in historical and biological context, this review offers an explicit definition of telescoping that includes the two criteria enumerated above. Defining telescoping in this way draws attention to many specific biological questions that are raised by the unusual anatomy of cetacean skulls; highlights the central role of sutures as the locus for changes in the sizes, shapes, mechanical properties, and connectivity of cranial bones; and emphasizes the importance of sutures in skull development and evolution. The unusual arrangements of cranial bones and sutures referred to as telescoping are not easily explained by what is known about cranial development in more conventional mammals. Discovering the evolutionary‐developmental processes that produce the extensive overlap characteristic of cetacean telescoping will give insights into both cetacean evolution and the “rules” that more generally govern mammalian skull function, development, and evolution. Anat Rec, 302:1055–1073, 2019. © 2019 Wiley Periodicals, Inc.
Chrysophanol Suppresses Hypoxia‐Induced Epithelial‐Mesenchymal Transition in Colorectal Cancer Cells
Authors: Deng Min , Xue Yong‐Ju , Xu Le‐Rong , Wang Qiang‐Wu , Wei Jun , Ke Xi‐Quan , Wang Jian‐Chao , Chen Xiao‐Dong 
Published: February 2019

ABSTRACTColorectal cancer (CRC) is a common human malignancy, accounting for 600,000 death cases annually worldwide. Chrysophanol is a naturally occurring anthraquinone compound and exhibits anti‐neoplastic activities. This study aims to explore the biological effects of chrysophanol on CRC metastasis and the relevant underlying mechanism. Cell proliferation assay, wound scratch assay, and Transwell invasion assay were used to examine the effect of chrysophanol on proliferation, migration, and invasion of CRC cells. Hypoxia‐inducible factor‐1α (HIF‐1α) shRNA was utilized to transfect CRC cells to examine the role of HIF‐1α in chrysophanol suppression of hypoxia‐induced epithelial to mesenchymal transition (EMT). The suppression effect of chrysophanol on hypoxia‐induced EMT in vivo was also validated in xenograft tumor models. In the present study, our findings indicated that chrysophanol has the capability to suppress hypoxia‐induced EMT in CRC in vitro and in vivo, and the possible mechanism involved is the inhibition of HIF‐1α via modulating PI3k/Akt signaling pathway. Collectively, the results indicated that chrysophanol can be used as an EMT and cancer metastasis inhibitor in the treatment of CRC. Anat Rec, 302:1561–1570, 2019. © 2019 American Association for Anatomy