bluuebunny/crossref_metadata_2025_split huggingface dataset:
Response of growth, yield, and quality of edible-podded snow peas to supplemental LED lighting during winter greenhouse production
Authors: Kong Yun , Zheng Youbin 
Published: May 2019

The occurrence of low natural light levels during winter months is a major limiting factor for greenhouse plant production in northern regions. To determine the effects of supplemental lighting (SL) on winter greenhouse production of pea pods, plant growth, pod yield, and quality were investigated under SL at a photosynthetic photon flux density (PPFD) of 50, 80, 110, and 140 μmol m−2 s−1, plus a no-SL control treatment, inside a Canadian greenhouse from January to March. Light-emitting diodes with a red-to-blue PPFD ratio of 4:1 and a 16 h photoperiod were used for the lighting treatments. During the trial period, the average natural daily light integral (DLI) inside the greenhouse was 6.6 mol m−2 d−1 and the average daily temperature was around 13 °C. Compared with the control, SL treatments increased pod yield and promoted plant growth, as demonstrated by faster main stem extension and greater aerial biomass. Also, total pod yield (g plant−1 or no. plant−1) and some growth traits (e.g., stem diameter, branch number, leaf thickness, and leaf chlorophyll content) were proportional to supplemental PPFD within the range of 0–140 μmol m−2 s−1. However, SL levels of 50–80 μmol m−2 s−1, corresponding to a total (natural + supplemental) DLI of 9.4–11.1 mol m−2 d−1, resulted in the best pod quality based on evaluations of individual fresh mass, length, soluble solids content, succulence, and firmness. Therefore, a total DLI ranging between 9.4 and 11.1 mol m−2 d−1 can be recommended as a target light level for greenhouse production of pea pods using SL under winter environment conditions.
The μ+μ− collider to sensitivity estimates on the magnetic and electric dipole moments of the tau-lepton
Authors: Köksal M. , Billur A. A. , Gutiérrez-Rodríguez A. , Hernández-Ruíz M. A. 
Published: May 2019

Using the effective Lagrangian formalism, the anomalous magnetic and electric dipole moments of the tau-lepton in the [Formula: see text] process are investigated with the future muon collider where [Formula: see text], 3 and 6 TeV. In addition, the bounds at the 95% confidence level on the dipole moments of the tau-lepton are estimated using different integrated luminosities. It is shown that the [Formula: see text] process leads to a remarkable improvement in the existing experimental bounds on the anomalous magnetic and electric dipole moments of the tau-lepton [Formula: see text] and [Formula: see text] at 95% C.L. for [Formula: see text], [Formula: see text] and [Formula: see text].
Effective Cancer Genotyping—Many Means to One End
Authors: Meador Catherine B. , Oxnard Geoffrey R. 
Published: May 2019

Abstract
Precision cancer medicine requires effective genotyping of every patient's tumor to optimally design treatment plans. Despite its imperfect sensitivity, the rapidity and convenience of cell-free DNA sequencing makes it an essential complement to tumor genotyping, which, when used appropriately, can aid the pursuit of effective genotyping for all patients.
See related article by Leighl et al., p. 4691
AKT1E17K Activates Focal Adhesion Kinase and Promotes Melanoma Brain Metastasis
Authors: Kircher David A. , Trombetti Kirby A. , Silvis Mark R. , Parkman Gennie L. , Fischer Grant M. , Angel Stephanie N. , Stehn Christopher M. , Strain Sean C. , Grossmann Allie H. , Duffy Keith L. , Boucher Kenneth M. , McMahon Martin , Davies Michael A. , Mendoza Michelle C. , VanBrocklin Matthew W. , Holmen Sheri L. 
Published: May 2019

Abstract

Alterations in the PI3K/AKT pathway occur in up to 70% of melanomas and are associated with disease progression. The three AKT paralogs are highly conserved but data suggest they have distinct functions. Activating mutations of AKT1 and AKT3 occur in human melanoma but their role in melanoma formation and metastasis remains unclear. Using an established melanoma mouse model, we evaluated E17K, E40K, and Q79K mutations in AKT1, AKT2, and AKT3 and show that mice harboring tumors expressing AKT1E17K had the highest incidence of brain metastasis and lowest mean survival. Tumors expressing AKT1E17K displayed elevated levels of focal adhesion factors and enhanced phosphorylation of focal adhesion kinase (FAK). AKT1E17K expression in melanoma cells increased invasion and this was reduced by pharmacologic inhibition of either AKT or FAK. These data suggest that the different AKT paralogs have distinct roles in melanoma brain metastasis and that AKT and FAK may be promising therapeutic targets.

Implications:
This study suggests that AKT1E17K promotes melanoma brain metastasis through activation of FAK and provides a rationale for the therapeutic targeting of AKT and/or FAK to reduce melanoma metastasis.
Randomized Double-Blind Placebo-Controlled Biomarker Modulation Study of Vitamin D Supplementation in Premenopausal Women at High Risk for Breast Cancer (SWOG S0812)
Authors: Crew Katherine D. , Anderson Garnet L. , Hershman Dawn L. , Terry Mary Beth , Tehranifar Parisa , Lew Danika L. , Yee Monica , Brown Eric A. , Kairouz Sebastien S. , Kuwajerwala Nafisa , Bevers Therese , Doster John E. , Zarwan Corrine , Kruper Laura , Minasian Lori M. , Ford Leslie , Arun Banu , Neuhouser Marian , Goodman Gary E. , Brown Powel H. 
Published: May 2019

AbstractObservational studies have reported an inverse association between vitamin D intake and breast cancer risk. We examined whether vitamin D supplementation in high-risk premenopausal women reduces mammographic density (MD), an established breast cancer risk factor. We conducted a multicenter randomized double-blind placebo-controlled trial in premenopausal women at high risk for breast cancer [5-year risk ≥ 1.67%, lifetime risk ≥ 20%, lobular carcinoma in situ, prior stage 0–II breast cancer, hereditary breast cancer syndrome, or high MD (heterogeneously/extremely dense)], with a baseline serum 25-hydroxyvitamin D [25(OH)D] ≤ 32 ng/mL. Participants were randomized to 12 months of vitamin D3 20,000 IU/week or matching placebo. The primary endpoint was change in MD from baseline to 12 months using the Cumulus technique. Secondary endpoints included serial blood biomarkers [25(OH)D, 1,25-dihydroxyvitamin D (1,25(OH)D), insulin-like growth factor (IGF)-1, IGF-binding protein-3] and MD change at 24 months. Among 208 women randomized, median age was 44.6 years, 84% were white, 33% had baseline 25(OH)D &lt; 20 ng/mL, and 78% had high baseline MD. Comparing the active and placebo groups at 12 months, MD changes were small and did not significantly differ. Mean MD changes at 12 and 24 months were −0.3% and −1.2%, respectively, in the active arm and +1.5% and +1.6% with placebo (P &gt; 0.05). We observed a mean change in serum 25(OH)D of +18.9 versus +2.8 ng/mL (P &lt; 0.01) and IGF-1 of −9.8 versus −1.8 ng/mL (P = 0.28), respectively. At 12 months, MD was positively correlated with serum IGF-1 and IGF-1/IGFBP-3 (P &lt; 0.01). This trial does not support the use of vitamin D supplementation for breast cancer risk reduction.
Do not Miss Rare and Treatable Cause of Early-Onset Hemolytic Uremic Syndrome: Cobalamin C Deficiency
Authors: Topaloglu Rezan , İnözü Mihriban , Gülhan Bora , Gürbüz Berrak , Talim Beril , Coşkun Turgay 
Published: May 2019

The most common disorder of vitamin B12 metabolism is methylmalonic aciduria and homocystinuria type cobalamin C (cblC), which accounts for most of the cases is referred to as cblC deficiency. Cobalamin deficiency is one of the causes of early-onset hemolytic uremic syndrome (HUS). Here, we present the cases of 2 infants with cobalamin deficiency who presented with early-onset HUS. The first patient was a 5-month-old female who was admitted to the hospital with seizure, pallor, and yellow-colored diarrheal stools. Initial laboratory examination showed direct Coombs test-negative hemolytic anemia. Later, she developed acute kidney injury and thrombocytopenia. Bone marrow aspiration showed megaloblastic features, and urinary examination showed elevated levels of methylmalonic acid (MMA), ­methyl citrate, and 3-hydroxypropionic acid. Methionine-restricted diet, parenteral hydroxocobalamine, folinic acid, carnitine, and betaine were initiated. Hemolytic activity was ­controlled with this treatment. Genetic screening showed homozygous mutation on the <i>MMACHC</i>gene (p.R161*[c.481C&#x3e;T]). The second patient was a 3-month-old male infant who was admitted to the hospital with malaise and diarrhea. Laboratory examination showed direct Coombs test-negative hemolytic anemia with leukopenia. Later he developed acute kidney injury and thrombocytopenia. Bone marrow aspiration revealed megaloblastic changes. Urine organic acid test showed increased levels of MMA. Parenteral hydroxocobalamine, folinic acid, carnitine, and betaine were initiated. He died due to respiratory failure and cardiac arrest. Direct sequencing of <i>MMACHC</i> identified homozygous mutation, c.271dup A. CblC deficiency is an important cause of early-onset HUS and prompt diagnosis will provide specific treatment modalities.
Scribes, Assistants, and the Materiality of Administrative Documents in Qin-Early Han China: Excavated Evidence from Liye, Shuihudi, and Zhangjiashan
Authors: Ma Tsang Wing 
Published: May 2019

As a result of the increasing administrative needs in the early imperial period, the profession of scribes was liberated from being the exclusive reserve of traditional hereditary families and opened to aspirants from non-hereditary families. Based on the excavated legal and administrative texts from Liye, Shuihudi, and Zhangjiashan, this paper explores the complementary nature of the scribes and assistants to understand the opening of the scribal profession. This paper also coins a concept of “administrative literacy,” which suggests that the materiality of written surfaces is a significant factor in understanding the literacy of administrative officials in early imperial China. Du fait des besoins croissants de l’administration aux débuts de l’époque impériale, la profession de scribe a cessé d’être l’apanage des familles qui traditionnellement en avaient l’accès exclusif, et a été ouverte à des candidats venus d’autres familles. En se fondant sur les documents administratifs et juridiques exhumés à Liye, Shuihudi et Zhangjiashan, cet article explore la nature complémentaire des rôles de scribe et d’assistant, en vue de comprendre une telle ouverture de la profession de scribe. Ce faisant, il propose le concept de “compétence administrative” et suggère que la matérialité des supports d’écriture était un facteur important pour comprendre les niveaux de compétence des fonctionnaires de l’administration aux débuts de l’ère impériale.
To Know the Enemy: The Zei qing huizuan, Military Intelligence, and the Taiping Civil War
Authors: Meyer-Fong Tobie 
Published: May 2019

AbstractThis article highlights the strategies and institutions that were mobilized in order to collect information during the Taiping Civil War (1851-1864). Through a close reading of the Zei qing huizuan 賊情彙纂 (Compendium of Rebel Intelligence), the article reveals that the Qing and its allies understood the Taiping as a political entity constituted on a familiar (dynastic) model and also in ethnographic terms (linguistic, sartorial, religious, regional). The article also demonstrates how individuals made use of their access to information to obtain patronage and employment within the pro-Qing camp. Finally, by spotlighting the political and moral language used by the authors of the Zei qing huizuan, the article makes obvious the deep relationship between intelligence and ideology.
Writing Landscapes into Civilization: Ming Loyalist Ambitions on the Mekong Delta
Authors: Ang Claudine 
Published: May 2019

AbstractAfter the collapse of the Ming dynasty, a group of Ming loyalists settled in Hà Tiên (located on the Vietnamese side of the modern border between Cambodia and Vietnam) on the Mekong delta. On those frontier lands, they built a settlement around a port that maintained close connections with Guangdong and Fujian. This article examines an eighteenth-century literary project that took as its focus ten scenic sites in Hà Tiên. The poems were distributed via the coastal trading network to poets in Vietnam and the Chinese mainland, who composed matching poems and returned them with the next sailing season. These poetic compositions functioned as a medium through which the originator of the project rendered his domain civilized by giving pattern (wen 文) to Hà Tiên’s natural environment. Moreover, he encoded in them messages that urged dispersed Ming loyalists to make Hà Tiên their new capital. Close study of the ten original poems uncovers the motivations of a second-generation Ming loyalist, who composed landscape poetry to create a new home outside the Chinese mainland.
Vedic Heritage for Environmental Stewardship
Authors: Dwivedi O.P. 
Published: May 2019

AbstractAn ethic of environmental stewardship can find valuable support in the world's existing cultural and spiritual traditions. This paper emphasises the Vedic heritage for eco-care, citing as examples numerous passages from Hindu sacred writings, including the Vedas, the Upanishads and the Bhagavad Gita. These scriptures demonstrate an early understanding of the need to temper our material appetites, and most importantly, to treat the earth with care and respect.
Arne Naess and the Norwegian Nature Tradition
Authors: Witoszek Nina 
Published: May 2019

AbstractThe current debate on the sources, meaning and implications of Arne Naess's Deep Ecology often refers to Spinoza, Gandhi and Socrates as the main inspirations of his vision. This essay explores the less familiar, Norwegian sources of Næss's thought and its rootedness in the Scandinavian Enlightenment. The context of the native tradition illuminates both the underlying central values of Deep Ecology - and its famous inconsistencies.
Earth's Insights ... and Inadequacies
Authors: Eaton Heather 
Published: May 2019

AbstractThe ecological wisdom from cross-cultural and religious insights provides needed historical references, guidance and ethical ideals for the ecological crisis. However, while supporting the project undertaken in Earth's Insights, this article challenges the tools used to develop a postmodern worldview. The lack of adequate discussions about the postmodern discourses, the new science, a 'universal' postmodern worldview, and the infusing of cross-cultural ecological ethics into such a worldview, leave the project vulnerable and utopian.
Earth's Insights: A Geographer's Perspective on its Rationale and Method
Authors: Proctor James 
Published: May 2019

AbstractJ. Baird Callicott's argument in Earth's Insights that a global conservation ethic resonant with Leopold and postmodern science is emerging emanates from a particular point of departure and method of justification. I provide a perspective on Callicot's rationale and method as a way of critically examining this argument's underlying basis, and in the spirit of fostering greater interaction between geographers and others with an intellectual interest in environmental ethics.
Gandhi's Khadi Spirit and Deep Ecology
Authors: Torchia Adela Diubaldo 
Published: May 2019

AbstractAlthough Mohandas K. Gandhi died before ecological concern was a pervasive issue, his ethical and religious approach to the treatment of all fellow creatures. was founded on an identification with all that lives. Such an identification is a prerequisite to the understanding of the profound biological and spiritual interconnectedness advocated by the modem deep ecology movement. For Gandhi the broad ideal of ahimsa, or non-injury, was out of reach without such an awareness of the interdepency of all of life. And ahimsa was also impossible without 'self-purification', a largely ascetical life of renunciation of material and physical indulgence. Gandhi was an early pioneer of both the more-with-less approach to ecologically-sound living, and deep ecology's perspective of the oneness of all elements of the biosphere, and their spiritual link.
Between Self-showing and Withdrawal: Heidegger’s Question of Being Reconsidered
Authors: Yang Guang 
Published: May 2019

Abstract
This article focuses on two Platonic concepts, δύναµις and χώρα, and Heidegger’s interpretation of them in his lecture courses on Greek philosophy. I try to demonstrate that these two concepts offer us insights into the dynamic movement of Being between self-showing and withdrawal. The aim of the article is to show that Being, as one of the greatest kinds in the Sophist, and the elusive χώρα in the Timaeus can open up new perspectives on the Heideggerian question of Being.
Myth, Primitive Sign, Poetry: From Cassirer to Heidegger
Authors: Leib Robert S. 
Published: May 2019

Abstract
Cassirer is important in 20th Century philosophy for the attention he gives to the fundamental relationship between myth and language. For Cassirer, myth is a non-subjective form of discourse wherein the origin of language coincides with both the human-divine encounter and the event of being itself. In this article, I trace the disagreement between Cassirer and Heidegger on the nature of the magical (or “primitive”) sign, which is at the heart of mythical discourse. While Heidegger initially argues that this form of sign is structurally impossible on the basis of his accounts of signs and language in Being and Time, he later comes to recognize that he had not properly accounted for its possibility within his phenomenological deduction. I conclude by describing how Heidegger’s notion of poetry eventually comes into alignment with the way Cassirer describes the function of myth and the magical sign.
Foreign Policy and Human Rights: Eritrea in the Post Algiers Period
Authors: Venkataraman Manickam , Gebrezgiabiher Thewodros Aregay 
Published: May 2019

Abstract
The interconnection between foreign policy and human rights is increasingly recognized both at academic and practice levels owing largely to the increasing internationalization and pre-eminence of human rights in global politics. In fact, human rights and democracy promotion have secured a place in foreign policy agendas and has gained significance in conflict resolution and peace work as well. Also, human rights norms and principles are recognized and enshrined in international laws and endorsed in regional treaties and national constitutions and has gained prime importance in international relations. As a result, internal and external dynamics of states have been effectively intertwined. This article analyses Eritrea’s foreign policy dynamics and its implications on human rights particularly in the aftermath of the Algiers Peace Agreement of December 2001 that concluded a three years border conflict with Ethiopia. This is done by enquiring whether the conflict and failure to implement the Algiers agreement has anything to do with the gross human rights violations that is witnessed in that country. The article proceeds to analyse the issue in a descriptive and analytical manner by using both secondary and primary sources, including treaties, official statements of public bodies, peace accords and un Drafts,1 and it concludes that the ongoing human rights violations is a product of the stalemate with Ethiopia that has provided a mechanism for continued repression and authoritarian rule in the country.
The Pedagogies of Preaching
Authors: Reinhardt Bruno 
Published: May 2019

Abstract
This article investigates Pentecostal preaching from a pedagogical angle, more exactly from the point of view of its transmission to apprentice pastors in a Ghanaian seminary or Bible school. My concern is the reproduction of a specific preaching style in this institution, an “international” one, governed by explicit and implicit norms. I revisit ethnographically some of these norms as they are conveyed and embodied through lectures about preaching, devotional routines, and student services. I call attention to the emic notion of “flow”, arguing that it lends good legibility to how Pentecostals articulate the multivalent status of preaching as a mimetic skill, a contingent performance, and an authentic expression of charisma. By doing so, flow also provides an interesting entry into the pedagogical dimension of the power assembling and expanding this organization transnationally.
Spanish Books in Michiel van Hamont’s Bookshop (1569): A Case Study of the Distribution of Spanish Books in Sixteenth-Century Brussels
Authors: Adam Renaud 
Published: May 2019

AbstractThis paper is dedicated to the study of the dissemination of Spanish books—books written in Spanish—during the 16th century in Brussels. This study is based on an inventory of the bookseller-printer Michiel van Hamont made in 1569, at the request of the authorities searching for heretical books. This is the first survey conducted on this subject. Spanish books that have effectively circulated within the Southern Netherlands, have generally been neglected by scholars. They mainly focused their attention on local production (which books were printed by whom) and export to the Iberian World (Kingdom of Spain and Americas). They studied the rise of Antwerp as a major centre of Spanish vernacular editions and its role in the dissemination of Spanish books. The first findings in this paper show that the distribution of Spanish books in Brussels in the mid-sixteenth century is merely a marginal phenomenon.
The Origins of Printing in Spanish in Antwerp
Authors: Gonzalo Sánchez-Molero José Luis 
Published: May 2019

AbstractThe city of Antwerp occupies a special place in the history of relations between Spain and the Netherlands during the centuries of the modern period. Hispano-Netherlandish relations in the centuries of the modern period have been studied from many different points of view. On this occasion we propose to delve into the origins of the very important links created around books and to deal, in particular, with the beginnings of the production of books in Spanish in Antwerp. Our intention here, therefore, is not to make a new listing of the editions printed at that time but a quite different one: to analyse the way in which this interesting publishing phenomenon developed in its origins and within a very specific period of time: the years prior to Christophe Plantin’s great publishing success.
Printing Spanish Books in the Southern and Northern Netherlands, 1520-1700
Authors: Wilkinson Alexander S. 
Published: May 2019

AbstractExploiting the most recent bibliographical information available, this article surveys Spanish-language printing in the southern and northern Netherlands from its tentative beginnings in 1520 to 1700. The anni mirabiles (1543-1560) have done much to shape perceptions of the trade in Spanish books. Yet, these were relatively short-lived. Overall, production grew steadily before 1701 with Antwerp then Brussels and Amsterdam becoming market leaders. A staggering 350 printers and publishers are known to have been involved in producing these works, although for almost all of them, printing in Spanish was never the main part of their output. The character of these works changed over the two centuries, with religious texts growing in importance. While every book had its own history, and intended market, it seems clear that Spanish-language books were not being produced exclusively or even predominantly to target the market in Spain itself—at least not directly.