bluuebunny/crossref_metadata_2025_split huggingface dataset:
LC-MS/MS method for the simultaneous determination of six phenolic acids in rat plasma and hypoglycemic effects in normal and T2DM rats after oral administration of Eleutherococcus senticosus fruits extract
Authors: Chen Jingnan , Sun Yanping , Li Sen , Wu Haibo , Guo Lijia , Wei Yuxin , Liu Yunwei , Li Xiangquan , Wang Meng , Wang Zhenyue , Wang Zhibin 
Published: December 2024

AbstractEleutherococcus senticosus (Rupr. & Maxim.) Maxim. fruits (ESF) is a natural health food that has been widely used in traditional medicine. This study aimed to establish and validate a rapid and sensitive method for determining of six phenolic acids in plasma of normal and T2DM rats by ultra-performance liquid chromatography–tandem mass spectrometry (UHPLC-MS/MS). Separation and quantification were performed on a Waters HSS T3 column (100 × 2.1 mm, 1.8 μm) with water (A) and methanol (B). The electrospray ionization (ESI) source was operated in negative ionization mode. Multiple reaction monitoring (MRM) was used to quantitatively analyzed hyperoside m/z 463.2→301.1, caffeic acid m/z 179.1→135.1, chlorogenic acid m/z 353.2→190.9, gallic acid m/z 169.0→125.1, protocatechuic acid m/z 153.1→109.1, and isofraxidin m/z 221.1→191.0, respectively. The hypoglycemic effect of ESF was verified by determining blood glucose and lipid levels in a type 2 diabetes model. This study laid the foundation for exploring ESF clinical guidelines in the future.
Materials approaches for next-generation encapsulated cell therapies
Authors: Krishnan Siddharth R. , Langer Robert , Anderson Daniel G. 
Published: December 2024

Abstract
Transplanted cells can act as living drug factories capable of secreting therapeutic proteins in vivo, with applications in the treatment of Type 1 diabetes (T1D), blood borne disease, vision disorders, and degenerative neural disease, potentially representing functional cures for chronic conditions. However, attack from the host immune system represents a major challenge, requiring chronic immunosuppression to enable long-lived cell transplantation in vivo. Encapsulating cells in engineered biomaterials capable of excluding components of the host immune system while allowing for the transport of therapeutic proteins, oxygen, nutrients, metabolites, and waste products represents a potential solution. However, the foreign-body response can lead to isolation from native vasculature and hypoxia leading to cell death. In this prospective article, we highlight materials-based solutions to three important challenges in the field: (i) improving biocompatibility and reducing fibrosis; (ii) enhancing transport of secreted protein drugs and key nutrients and oxygen via engineered, semipermeable membranes; and (iii) improving oxygenation. These efforts draw on several disciplines in materials’ research, including polymer science, surfaces, membranes, biomaterials’ microfabrication, and flexible electronics. If successful, these efforts could lead to new therapies for chronic disease and are a rich space for both fundamental materials’ discovery and applied translational science.

Graphical Abstract
Church and university in Scotland: Challenges and prospects
Authors: Fergusson David 
Published: December 2024

This paper was originally delivered as the third D. W. D. Shaw memorial lecture at the University of Aberdeen on 27 May 2024. It examines the shifting patterns in the relationship of church and academy in Scotland from the establishment of the four ancient universities to the present day. Despite historical changes, most notably the Reformation, the church and the academy maintained a cooperative relationship in the shared project of producing a well-educated clergy. Yet this has altered significantly in recent decades. Contributory factors include a steep decline in the number of ordinands, the emergence of religious studies, and diverging economic circumstances. The paper concludes by examining future prospects for theological education, addressing critical questions concerning the academic pursuit of a confessional Christian theology amidst rising secularism and alternative approaches to the study of religion.
Synergistic Application of Geoelectrical Methods for Mapping Placers along the Coastal Periphery of Southern Odisha, India
Authors: Singh Akarsh , Agrahari Sudha 
Published: December 2024

ABSTRACT
This study examines the distribution and amount of placer deposits enriched with heavy minerals along the coastal region of Odisha, India utilizing a combination of geoelectrical techniques. Abundant heavy mineral placers have been identified along the southern coast of Odisha. However, while geological investigations have been conducted, there is a notable absence of geophysical analyses in this specific area. To ascertain both the horizontal and vertical extensions of heavy mineral placer deposits, a comprehensive investigation was undertaken, involving the execution of 23 ERT (Electrical Resistivity Tomography) and TDIP (Time-Domain Induced Polarization) profiles within the designated study zone. These profiles unveiled substantial heavy-mineral zones spanning from shallow layers to depths of approximately 10-15 m. Two primary patterns of mineralization were discerned: firstly, dispersed occurrences which manifested closer to the surface, characterized by irregular black patches of minerals; secondly, concentrated mineralization found at moderate to significant depths, hinting at concealed or buried deposits. Considering the presence of conductive minerals (ilmenite, magnetite) within the beach placers of the study locale, the application of ERT and IP methods proved to be viable. Additionally, the mineralization trends exhibited variance as one traversed from the southwest to the northeast within the study area. Notably, the resistivity of the heavy minerals ranged from 0.1 to 1.1 Ωm, coupled with chargeabilities surpassing 20 mV/V. Significantly, the arrangement of alternating heavy mineralization layers within the sand formations implied the potential presence of stratal anisotropy. Consequently, a specialized code was developed and implemented to perform 2D anisotropic inversion of the ERT data. The application of this anisotropic inversion rectified the depth estimations for concealed pockets of heavy mineralization. While conventional isotropic inversion suggested a concealed mineralization pocket at depths of 15-32 m, the anisotropic inversion revealed that the same mineral-bearing strata existed at depths of 16–28 m.
A new species of Talantodiscus (Family Pleurotomariidae ) from the Late Jurassic of the Kutch, Western India
Authors: Saha Sandip , S. Das Shiladri , Mondal Subhronil , Bose Kanishka 
Published: December 2024

ABSTRACT
Talantodiscus is a rare genus within the pleurotomariid gastropods represented by only seven species from nine different Mesozoic localities of New Zealand and Europe, appearing from the late Middle Triassic (Late Ladinian) to the Middle Jurassic (Bajocian) in the fossil record. In the present paper, we report a new species, i.e., Talantodiscus gujaratensis, from the topmost Tithonian bed of the Kutch Basin, western India. The new find extends the palaeobiogeographic range of the genus to the western India beside New Zealand and European localities. Also, the last appearance datum (LAD) of the genus is extended to the latest of the Jurassic (Tithonian).
A New Fauna from the Deccan Intertrappean Sediments of Central India Reveals KP Extinction and Survivorship, and Origins of Asiatic Freshwater Molluscs
Authors: Delvene Graciela , Munt Martin C. , Paul Sharmistha , Gangopadhyay T.K. 
Published: December 2024

ABSTRACT
A previously undescribed Danian freshwater intratrappean mollusc fauna from Barga, Shahpura District, Madhya Pradesh, Central India is dominated by bivalves and pulmonate gastropods. We introduce the new unionid genus and species Shahpuranaia shai (Tribe Indochinellini) with other bivalve taxa including a margaritiferid, and a sphaeriid tentatively assigned to Pisidium. The genus Telankhedilymnaea is introduced for elongate fusiform Lymnaeid gastropods. We record KP extinction survivorship amongst the Lymnaeids indicating that the intertrappeans were a Late Cretaceous to Early Palaeogene refuge. The Barga fauna lived prior to the diversification of the East and Southeast Asian mollusc faunas during the convergence between the Indian plate and Burma Terrane with Asia.
Tradução de poemas de Marina Tsvietáieva por Augusto de Campos
Authors: Campos Augusto De 
Published: December 2024

Tradução dos poemas "Vivo não morto", "Com paciência" e "Psiquê", da poeta russa Marina Tsvietáieva (1894-1941). Os dois primeiros foram inscritos em fotos da autora, reelaboradas graficamente, e o terceiro sobre um perfil de Tzvietáieva, de autoria de Elizabeta Sierguéieva Kruglíkova (1865-1941).
Moral, paz y justicia en la ética colombiana
Authors: Suarez Robinsson 
Published: December 2024

This paper will address three fundamental moments. These are: morality, peace and justice with the state. These three moments seek to understand Colombian ethics, how its morality experiences frictions with its social ethics and how the transcendence of this problem is represented by a peace articulated with justice, we will explore the deep social fracture that exists between individual morality and collective ethics in Colombia. We will ask what is the reality that has generated this estrangement and how violence has played a fundamental role in this dissociation.
Hipercolesterolemia familiar: un enemigo oculto desde la infancia, ¿olvidado o infrecuente?
Authors: Tirado Pérez Irina Suley , Granados Pérez José Vicente , Lopera Cañaveral María Victoria , Correa Saldarriaga Johana 
Published: December 2024

Resumen
INTRODUCCIÓN: La hipercolesterolemia familiar (HF) es el trastorno metabólico genético más común, caracterizado por niveles marcadamente elevados de lipoproteínas de baja densidad desde el nacimiento, que conducen a enfermedad cardiovascular aterosclerótica (Atherosclerotic Cardiovascular Disease, ASCVD) y muertes prematuras. El propósito de esta revisión es compartir un caso clínico con esta patología y realizar una revisión actual sobre el diagnóstico y el manejo de estos pacientes con el fin de una concientización que contribuya a la disminución de la morbimortalidad.
CASO CLÍNICO: Paciente femenino de 6 años, que asiste a control de endocrinología pediátrica por sobrepeso, asintomática. Con antecedentes familiares de dislipidemia y enfermedad cardiovascular, padre con dislipidemia, abuela y tías paternas con enfermedad cerebrovascular a los 50 años, abuelo materno con dislipidemia, abuela y tia materna con aneurisma cerebral. Se le realiza paraclínicos que evidenciaron hipercolesterolemia a expensas del colesterol LDL, de dificil control a pesar de control de hábitos y manejo multidisciplinario. Se sospecha de hipercolesterolemia familiar y se realiza prueba genética con detección de variante heterocigota del gen LDLR (receptor LDL).
CONCLUSIONES: La hipercolesterolemia familiar es la principal causa de accidente cerebrovascular (ACV), esta inicia desde la infancia. Por lo cual, es de vital importancia reconocer los antecedentes personales con el fin de realizar un diagnóstico temprano. A pesar de los grandes avances en la enfermedad y el manejo efectivo, la HF sigue siendo subdiagnosticada generando un impacto en morbimortalidad y salud Pública.
Embarazo exitoso de una adolescente con leucemia granulocítica crónica en la era de las terapias blanco
Authors: Garrido Luisa Basauri , García Monserrat Vázquez , Pérez Irlanda Campos , Chanes Daniela Jimenez , Cayoja Valverda Ilsen , Olaya Nieto Alberto , Vázquez Zúñiga Denisse , Olaya Vargas Alberto , Rincones Monarrez Doris , Cervantes Delgado María 
Published: December 2024

Resumen
INTRODUCCIÓN: Las terapias blanco como el mesilato de Imatinib, el primero de los inhibidores de la tirosina quinasa, en la práctica clínica ha cambiado drásticamente el pronóstico de los pacientes con leucemia granulocítica crónica y otro tipo de cáncer; sin embargo, su riesgo teratogénico es elevado con base a su mecanismo de acción, como lo demuestran estudios en modelos murinos. A pesar de esto, su capacidad teratogénica no está clara en humanos.
REPORTE DE CASO: Adolescente de 16 años con diagnóstico de leucemia granulocítica crónica con tratamiento a base de Mesilato de Imatinib, el cual fue administrado durante todo el embarazo, sin que el recién nacido presentara algún efecto teratogénico. La paciente presentó amenaza de parto pre termino por lo que hubo la necesidad de interrumpir el embarazo en la semana 34 de la gestación, obteniéndose un producto hipotrófico, con buen estado general y adecuado desarrollo durante 2 años de seguimiento.
CONCLUSIONES: Si bien en este caso no se describe ningún efecto teratogénico sobre el producto del embarazo durante el mismo y su seguimiento extrauterino, se recomienda que todas las y los adolescentes utilicen un método anticonceptivo durante el tratamiento con este tipo de terapias blanco ante el potencial de su mecanismo de acción para afectar la embriogénesis, así como en el caso de embarazos programados esperar hasta que la paciente tenga 48 meses con remisión molecular completa.
Competências Digitais em Projetos Pedagógicos da Licenciatura em Matemática a Distância
Authors: Araújo Filho Roberto Mariano , Silva Robson Santos da , Santos Filho José Elias dos 
Published: December 2024

Este artigo investiga as competências digitais em componentes curriculares de três cursos de licenciatura em Matemática na modalidade a distância do estado do Rio Grande do Norte, utilizando como base os projetos pedagógicos dos cursos, disponíveis online. As competências digitais partem do quadro de Competências Digitais para a formação inicial docente de Araripe e Lins (2020), que se alinha à demanda da Base Nacional Comum para a formação inicial de professores. A análise de conteúdo das ementas foi realizada pautando-se no quadro de competências digitais distribuídas em três eixos: Pedagógico, Cidadania Digital e Desenvolvimento profissional. Os resultados mostram que as instituições pesquisadas precisam aprimorar a atualização dos projetos pedagógicos dos cursos, para atender à demanda do documento e as necessidades da sociedade atual.

Palavras-chave: Competências digitais. Educação a distância. Formação de professores. Matemática.
Cultural capital, Islamism, and political distrust in Indonesia General Election: an ethnicity-based community engaged in Islamic Defenders Front (FPI)
Authors: Basya Muhammad Hilali , Hamka Hamka 
Published: December 2024

Although there have been many studies investigating Islamist movements andtheir views concerning the relationship between Islam and politics, very rarestudies examining the ways particular ethnicity-based Islamist group invent andrevitalize their cultural capital in dealing with Islamism. Based on the case of therole of FPI (the Islamic Defenders Front) group in Jakarta rejecting the resultof Pemilu 2019 (Indonesian General Election), this study aims to investigatethe way a young Batavian community that is engaged in the FPI (a semi radicalIslamist organization) interpret their Batavian values and tradition in dealing with Islamism. This research uses a case study approach that investigates culturalcapital and its influence to a young Batavian community joining the FPI. Thisstudy relies more on in-depth interviews with the members as well as observation.Based on the fieldwork this article shows that tension in national political levelin Pemilu 2019 which polarized society had encouraged these young Batavians tobe engaged in an organization connecting them to wider Islamic groups. Insteadof Muhammadiyah or Nahdatul Ulama (NU), their cultural capital is moresupportive encouraging them to be engaged with the Islamic Defenders Front(FPI). Through this engagement in FPI and participation in political distrustrejecting the result of Pemilu 2019 they were not only involved with nationalissues, but also local issues dealing with their domination as an indigenous groupliving in an urban area.
Crowdfunding for inter-faith peace: youth, networked social movement, and muslim philanthropy NGOs in contemporary Indonesia
Authors: Anoraga Bhirawa 
Published: December 2024

This study examines the involvement of Indonesian youth and Muslimphilanthropy NGOs in the promotion of inter-faith harmony throughcrowdfunding. Crowdfunding or online fundraising has been rapidly growing inIndonesia. It has been used to respond to various issues, among which is religiousviolence. Oftentimes, when radical acts happened in Indonesia, people turnedto crowdfunding to express inter-faith solidarity and support. This study drawsfrom the concept of networked social movement to explain the characteristicsof crowdfunding campaigns for inter-faith harmony. This concept highlightscontemporary online movements that are spontaneous, leaderless, and temporalin nature which is distinct from the well-organized movements commonly studiedby scholars. This study employs digital ethnography on campaigns that respondedto religious violence in the largest crowdfunding platform in Indonesia, Kitabisa,which is complemented by interviews with the campaign initiators and Muslimphilanthropy NGOs. This article argues that the characteristics of network social movement fit with the current youth generation that is assumed to be sociallyapathetic and more immersed in developing themselves and consuming media.Nevertheless, despite the spontaneous and temporal tenets, the youth’s inter-faithmovements were able to mobilize a significant number of donations and attractMuslim NGOs that were often perceived to be sectarian to support the inter-faithcampaigns. The findings of this study contribute to the studies on Indonesianyouth, Islamic philanthropy, and the state of inter-faith relations in Indonesia,which was argued to be experiencing a conservative turn.
Improving the Islamic Education Learning Quality through Classroom Management in Madrasah Ibtidaiyah
Authors: Mahfud Moh. , Razak Akhmad Zakki Abd. , Gahlan Waleed Yahya 
Published: December 2024

This research aims to describe classroom management practices and teachers' efforts to improve the quality of Islamic religious education learning in Madrasah Ibtidaiyah. A qualitative approach with a case study method was employed, utilizing observation, interviews, and document studies for data collection. Data analysis involved reduction, presentation, validation, and conclusion drawing. The findings reveal that classroom management by teachers includes preparation of essential teaching skills. Teachers enhance classroom management through various approaches: discipline, reward and punishment, teaching, attitude, and group process. This research contributes to the academic understanding of classroom management implementation in Islamic religious education at the Madrasah Ibtidaiyah level. In Islamic education, classroom management is a crucial skill for educators, aligning with the Prophet Muhammad’s SAW emphasis on purposeful, precise, and thorough efforts in teaching.
A Comparative Study between Legally Imported and Smuggled Brands of Atenolol and Atorvastatin Drugs Marketed in Aden, Yemen
Authors: Al-Nasi Abdullah Ali , Banafea Abdulmalek , Al-helali Abdulaziz , Badhri Abdullah , Al-obadi Ibrahim , Al-haj Marwah , Al-obadi Muaadh , Al-qumishi Nasser , Alkhalifi Omar , Al-akbari Salem , Al-haddad Thekra 
Published: December 2024

The purpose of this project was to compare the quality control parameters of both legally imported and smuggled products of Atenolol (Tenormin®) and Atorvastatin (Ateroz®) drugs marketed in Aden, Yemen. Hundred tablets from each studied product were taken from the market and were determined by the quality control parameters including weight variation, hardness, diameter, thickness, disintegration, leakage and assay tests as well as identification of drugs by Fourier Transform Infra-Red spectrophotometer. The result of this study showed that both legally imported and smuggled tested tablets of Atenolol (Tenormin®) in accordance with quality control specifications except the assay test of smuggled Tenormin where the result shows a value of 81% only and thickness test of smuggled Tenormin that show the values outside of the acceptable range. On the other hand, legally imported and smuggled tablet of Atorvastatin (Ateroz®) complied quality control specifications for the tested parameters. We concluded that the tested drugs complied most of quality control specifications with presence of a variation in some quality control tests between legally imported and smuggled products.
The dementia certified nurse process for acquiring knowledge for care of older adult patients with dementia in acute care hospitals: a qualitative descriptive study
Authors: Kabaya Sonoko , Nagahata Tayo , Juanamasta I Gede 
Published: December 2024

Introduction: This study aimed to explore DCNs’ perceived knowledge acquisition in older adult patients with dementia in acute-care hospitals.
Methods: The study used qualitative methods, with 14 Japanese DCNs involved in the snowball sampling method. Face-to-face interviews were conducted between June and December 2016 by the principal investigator. A qualitative content analysis was used in this study. The study results were divided into nine categories and 31 sub-categories.
Results: This study highlights the process through which DCNs in acute-care hospitals acquire expertise in caring for older adults with dementia. Initially, DCNs faced dilemmas between patients’ resistance to treatment and their professional priorities, leading to emotional and cognitive shifts that motivated them to seek specialized knowledge and refine their care methods. By reflecting on their experiences, integrating patient-centered approaches, and sharing insights with team members, DCNs deepened their understanding, adapted care strategies, and enhanced their clinical capacity to meet patients' needs effectively.
Conclusions: Nurses should provide appropriate training before taking care of the patients. Knowledge should be combined with patient’s problems and behavior. Thus, nurses become more flexible in adapting to patients with dementia. These findings emphasize the importance of fostering reflective practices and educational interventions to enhance DCNs’ expertise, enabling them to provide patient-centered care and improve outcomes for older adults with dementia.
Addressing Loneliness in Dementia Patient’s Caregiver Through Spiritual Aspect
Authors: Christophorus Aditya Pawitan  , Agustina Konginan  
Published: December 2024

Introduction: In this brief case report, we aim to focus on the spiritual aspect and how it may benefit in addressing loneliness. Case: The case is a female 62 years old, diagnosed with generalized anxiety disorder with a psychosocial stressor of perceived isolation (loneliness), treatment approach consists of medication and spiritual-integrated cognitive behavioral therapy focused on her loneliness. Discussion: According to the definition spirituality is related to a transcendental being (vertical) and relation with others, the environment, and oneself (horizontal). In loneliness, the psychosocial symptom of perceived social isolation might be caused by the falling apart of a spiritual relation, either vertical or horizontal. Conclusion: Loneliness might be prolonged by a change in spiritual value and addressing loneliness through a spiritual aspect is an area that needs to be explored in future studies.

Keywords: Spirituality, Loneliness, Spiritual Intervention, Caregiver, Mental Health