bluuebunny/crossref_metadata_2025_split huggingface dataset:
Repeated intranasal ketamine for treatment-resistant depression – the way to go? Results from a pilot randomised controlled trial
Authors: Gálvez Verònica , Li Adrienne , Huggins Christina , Glue Paul , Martin Donel , Somogyi Andrew A , Alonzo Angelo , Rodgers Anthony , Mitchell Philip B , Loo Colleen K 
Published: March 2018

Background: Ketamine research in depression has mostly used intravenous, weight-based approaches, which are difficult to translate clinically. Intranasal (IN) ketamine is a promising alternative but no controlled data has been published on the feasibility, safety and potential efficacy of repeated IN ketamine treatments. Methods: This randomised, double-blind, placebo-controlled pilot study compared a 4-week course of eight treatments of 100 mg ketamine or 4.5 mg midazolam. Each treatment was given as 10 separate IN sprays, self-administered 5 min apart. The study was stopped early due to poor tolerability after five treatment-resistant depressed participants were included. Feasibility, safety (acute and cumulative), cognitive and efficacy outcomes were assessed. Plasma ketamine and norketamine concentrations were assayed after the first treatment. Results: Significant acute cardiovascular, psychotomimetic and neurological side effects occurred at doses < 100 mg ketamine. No participants were able to self-administer all 10 ketamine sprays due to incoordination; treatment time occasionally had to be extended (>45 min) due to acute side effects. No hepatic, cognitive or urinary changes were observed after the treatment course in either group. There was an approximately two-fold variation in ketamine and norketamine plasma concentrations between ketamine participants. At course end, one participant had remitted in each of the ketamine and midazolam groups. Conclusions: IN ketamine, with the drug formulation and delivery device used, was not a useful treatment approach in this study. Absorption was variable between individuals and acute tolerability was poor, requiring prolonged treatment administration time in some individuals. The drug formulation, the delivery device, the insufflation technique and individual patient factors play an important role in tolerability and efficacy when using IN ketamine for TRD.
Sustained Delivery of Transforming Growth Factor β1 by Use of Absorbable Alginate Scaffold Enhances Rotator Cuff Healing in a Rabbit Model
Authors: Yoon Jong Pil , Lee Chang-Hwa , Jung Jae Wook , Lee Hyun-Joo , Lee Yong-Soo , Kim Ja-Yeon , Park Ga Young , Choi Jin Hyun , Chung Seok Won 
Published: March 2018

Background: The failure rate for healing after rotator cuff repair is relatively high. Purpose: To establish a system for sustained release of transforming growth factor β1 (TGF-β1) using an alginate scaffold and evaluate the effects of the sustained release of TGF-β1 on rotator cuff healing in a rabbit model. Study Design: Controlled laboratory study. Methods: Before the in vivo animal study, a standard MTS assay was performed to evaluate cell proliferation and metabolic activity on the alginate scaffold. Additionally, an enzyme-linked immunosorbent assay was performed to confirm the capacity of the sustained release of TGF-β1-containing alginate scaffold. Once the in vitro studies were completed, bilateral supraspinatus tendon repairs were performed in 48 rabbits that were allocated to 3 groups (n = 16 each) (group 1, supraspinatus repair only; group 2, supraspinatus repair with TGF-β1 single injection; group 3, supraspinatus repair with TGF-β1 sustained release via an alginate-based delivery system). Biomechanical and histological analyses were performed to evaluate the quality of tendon-to-bone healing at 12 weeks after rotator cuff repair. Results: The cell proliferation rate of the alginate scaffold was 122.30% compared with the control (fresh medium) group, which confirmed that the alginate sheet had no cytotoxicity and enhanced cell proliferation. Additionally, the level of TGF-β1 was found to increase with time on the alginate scaffold. Biomechanically, group 3 exhibited a significantly heightened ultimate failure load compared with groups 1 and 2 (group 1, 74.89 ± 29.82 N; group 2, 80.02 ± 34.42 N; group 3, 108.32 ± 32.48 N; P = .011) and more prevalent midsubstance tear compared with group 1 ( P = .028). However, no statistical differences were found in the cross-sectional area of the supraspinatus tendon (group 1, 32.74 ± 9.38; group 2, 33.76 ± 8.89; group 3, 34.80 ± 14.52; P = .882) and ultimate stress (group 1, 2.62 ± 1.13 MPa; group 2, 2.99 ± 1.81 MPa; group 3, 3.62 ± 2.24 MPa; P = .317). Histologically, group 3 exhibited a significantly heightened modified total Bonar score (group 1, 5.00 ± 1.54; group 2, 6.12 ± 1.85; group 3, 7.50 ± 1.31; P = .001). In addition, the tendon-to-bone interface for group 3 demonstrated better collagen orientation, continuity, and organization, and the area of new fibrocartilage formation was more evident in group 3. Conclusion: At 12 weeks after rotator cuff repair, the authors found improved biomechanical and histological outcomes for sustained release of TGF-β1 using alginate scaffold in a rabbit model. Clinical Relevance: The alginate-bound growth factor delivery system might improve healing after rotator cuff repair in humans.
Teaching Bible for Transformation
Authors: Smallbones Jackie L. 
Published: March 2018

The fact that the Bible transforms lives, or rather, the engagement with scripture transforms lives, begs the question: How? This article addresses this question by first considering two prior questions: For whom was the Bible written? Why was the Bible written? How we answer these two questions will influence what we believe about, and therefore how we teach the Bible for transformation. To the first question, I suggest the Bible was written for an elect community, the people of God and therefore how it transforms will have something to do with that community, more particularly, where we teach the Bible. To the second question, I suggest that the Bible was written to make God known. Most of the rest of the article addresses what this means and how we can teach in ways where God is known in loving, experiential and obedient relationships. Therefore, the article concludes, not with a method for teaching, but with suggestions for teaching to encounter the Living God.
Book Review: The Five Smooth Stones: Essential Principles for Biblical Ministry
Authors: Mohler James W. , Kimber Thomas 
Published: March 2018

Below, 15 books are reviewed, presented in the following general order: foundations, children/family ministry, youth ministry, adult ministry, teaching-learning process, leadership/administration, and spirituality/spiritual formation—although reviews may not appear for each area. We invite readers to consider reviewing a book for CEJ. Guidelines are available in downloadable documents at www.biola.edu/cej . A list of each area and responsible editors appears after the last review. In this addition, we express appreciation to Dr. Norma Hedin and her team for compiling the excellent textbook review section in the area of foundations of Christian educational ministry.
Book Review: Formational Children's Ministry: Shaping Children Using Story, Ritual and Relationship
Authors: Carr Jane , Welch Teresa D. 
Published: March 2018

In this section 15 books are reviewed, presented in the following general order: children/family ministry, youth ministry, adult ministry, foundations, teaching-learning process, spirituality/spiritual formation, and leadership/administration—although reviews may not appear for each area. We invite readers to consider reviewing a book for CEJ. Guidelines are available in downloadable documents at www.biola.edu/cej . A list of each area and responsible editors appears after the last review. Note: Jim Mohler, who had been serving as Book Review Editor for the CEJ, stepped down from this role in Spring 2009 to focus energy on treatments and recovery from cancer. Our prayers are with him for a complete recovery. Jane Carr, Associate Professor of Christian Education at Talbot School of Theology, Biola University, now serves as our Book Review Editor. You can reach her at: reviews.cej@biola.edu
Baptismal Theology and Practices and the Spiritual Nurture of Children Part I: Early and Medieval Church
Authors: Lawson Kevin E. 
Published: March 2018

Baptismal theology and practices have always had a major influence on the educational efforts of the church, either setting expectations for those who are to be baptized or establishing requirements of instruction for children following their baptism. This article addresses the changes in baptismal theology and practice during the early and medieval church eras and their influence on the educational ministries of the church, particularly with children. A second article reviews changes from the Reformation to the present and provides a case study of how Horace Bushnell's views of the spiritual nurture of children are grounded in his theology of baptism. 1 1 These two articles are based on a paper presented at the 2009 Children's Spirituality Conference: Christian Perspectives, held at Concordia University, River Forest, IL. The audience was faculty, researchers, graduate students, and ministry practitioners from a variety of Christian traditions, including Catholic, Mainline Protestant, and Evangelical Protestant. A version of this paper is forthcoming in a book on children's spirituality. It should be available in 2011.
Baptismal Theology and Practices and the Spiritual Nurture of Children Part II: Reformation to the Present
Authors: Lawson Kevin E. 
Published: March 2018

Baptismal theology and practices have always had a major influence on the educational efforts of the church, either setting expectations for those who are to be baptized or establishing requirements of instruction for children following their baptism. The first article in this series addressed the changes in baptismal theology and practice in the early and medieval church and their influence on the educational ministries of the church of these eras, particularly with children. This second article reviews changes in theology and practice from the Reformation to the present era and their impact on the church's ministry with children, providing a case study of theological reflection by Horace Bushnell on baptism and the spiritual nurture of children. It closes with recommendations for ministry with children today in light of baptismal beliefs and practices. 1 1 These two articles are based on a paper presented at the 2009 Children's Spirituality Conference: Christian Perspectives, held at Concordia University, River Forest, IL. The audience was faculty, researchers, graduate students, and ministry practitioners from a variety of Christian traditions, including Catholic, Mainline Protestant, and Evangelical Protestant. A version of this paper is forthcoming in a book on children's spirituality. It should be available in 2011.
Results of the International Wet Steam Modeling Project
Authors: Starzmann Jörg , Hughes Fiona R , Schuster Sebastian , White Alexander J , Halama Jan , Hric Vladimir , Kolovratník Michal , Lee Hoon , Sova Libor , Št’astný Miroslav , Grübel Marius , Schatz Markus , Vogt Damian M , Patel Yogini , Patel Giteshkumar , Turunen-Saaresti Teemu , Gribin Vladimir , Tishchenko Victor , Gavrilov Ilya , Kim Changhyun , Baek Jehyun , Wu Xiaoming , Yang Jiandao , Dykas Sławomir , Wróblewski Włodzimierz , Yamamoto Satoru , Feng Zhenping , Li Liang 
Published: March 2018

The purpose of the “International Wet Steam Modeling Project” is to review the ability of computational methods to predict condensing steam flows. The results of numerous wet-steam methods are compared with each other and with experimental data for several nozzle test cases. The spread of computed results is quite noticeable and the present paper endeavours to explain some of the reasons for this. Generally, however, the results confirm that reasonable agreement with experiment is obtained by using classical homogeneous nucleation theory corrected for non-isothermal effects, combined with Young’s droplet growth model. Some calibration of the latter is however required. The equation of state is also shown to have a significant impact on the location of the Wilson point, thus adding to the uncertainty surrounding the condensation theory. With respect to the validation of wet-steam models it is shown that some of the commonly used nozzle test cases have design deficiencies which are particularly apparent in the context of two- and three-dimensional computations. In particular, it is difficult to separate out condensation phenomena from boundary layer effects unless the nozzle geometry is carefully designed to provide near-one-dimensional flow.
Stability of vincristine sulfate, doxorubicin hydrochloride and etoposide phosphate admixtures in polyisoprene elastomeric pump supporting transition of the EPOCH regimen to outpatient care
Authors: Svirskis Darren , Behera Sairam , Naidoo Neera , Beachman Joanne , Raina Tarsha , Zhou Yongzhi , Berkahn Leanne , Costello Ian , Gu Yongchuan 
Published: March 2018

Background The EPOCH regimen, consisting of vincristine sulfate, doxorubicin hydrochloride, and etoposide phosphate, is typically administered by continuous infusion over four days to oncology inpatients. If the EPOCH regimen was available to be administered through portable elastomeric pumps, chemotherapy could be transitioned to an outpatient setting, reducing inpatient bed days and overall healthcare costs. However, a lack of stability data for the admixtures in the elastomeric infusion devices currently prevents the transition of the regime to an outpatient setting. The purpose of this study is to determine the physical and chemical stability of the admixture in polyisoprene elastomeric pumps under different storage conditions to support the transition of the EPOCH regime to an outpatient setting. Methods The physico-chemical stability of three admixtures at a range of clinically relevant concentrations compounded in polyisoprene elastomeric infusors was determined when refrigerated at 2–6℃ over a 14-day period followed by 35℃ up to 7 days in the dark, and under standardized fluorescent light to simulate scenarios in clinical practice. Results All tested admixtures were compatible and the drugs were stable in the elastomeric infusors for up to 14 days when stored at 2–6℃ followed by 7 days at 35℃ in the dark, with nominal losses of <5%. The major degradant of etoposide phosphate was its active form etoposide. There was no degradation (<1% loss) found when the admixture was exposed to a standardized fluorescent light dose of 80 klux-h (25℃) for 10 h. The temperature and light conditions the infusors were exposed to during the stability study were more severe than the conditions determine during clinical administration. Conclusion The extended stability of the three infusional admixtures compounded in elastomeric infusion pumps demonstrated herein permits advance preparation and storage of these drugs, reducing pharmacy compounding resources. The demonstrated stability at 35℃ and under light exposure, conditions more severe than those experienced during clinical practice, support continuous infusions for up to seven days from the elastomeric infusors without a loss of potency. The proven stability of the EPOCH regimens in the tested elastomeric infusion device supports the transition of treatment to an outpatient setting which will reduce inpatient bed days and overall healthcare costs.
Detection of feline coronavirus mutations in paraffin-embedded tissues in cats with feline infectious peritonitis and controls
Authors: Sangl Laura , Matiasek Kaspar , Felten Sandra , Gründl Stefanie , Bergmann Michele , Balzer Hans-Jörg , Pantchev Nikola , Leutenegger Christian M , Hartmann Katrin 
Published: March 2018

Objectives The amino acid substitutions M1058L and S1060A in the spike protein of feline coronavirus (FCoV) have been postulated to be responsible for the development of the pathogenic feline infectious peritonitis virus (FIPV), which causes feline infectious peritonitis (FIP). The aim of the following study was to investigate the presence of mutated virus in tissue samples of cats with and without FIP. Methods The study population consisted of 64 cats, 34 of which were diagnosed with FIP and 30 control cats. All cases underwent autopsy, histopathology and immunohistochemistry (IHC) for FCoV. Furthermore, a genotype-discriminating quantitative reverse transcriptase PCR (RT-qPCR) was performed on shavings of paraffin-embedded tissues to discriminate between cats with FIP and controls, and the sensitivity and specificity of this discriminating RT-qPCR were calculated using 95% confidence intervals (CIs). Results Specificity of genotype-discriminating RT-qPCR was 100.0% (95% CI 88.4–100.0), and sensitivity was 70.6% (95% CI 52.5–84.9). In cats with FIP, 24/34 tested positive for FIPV. In samples of three control cats and in seven cats with FIP, FCoV was found, but genotyping was not possible owing to low FCoV RNA concentrations. Out of the positive samples, 23 showed the amino acid substitution M1058L in the spike protein and none the substitution S1060A. One sample in a cat with FIP revealed a mixed population of non-mutated FCoV and FIPV (mixed genotype). For one sample genotyping was not possible despite high viral load, and two samples were negative for FCoV. Conclusions and relevance As none of the control animals showed FCoV amino acid substitutions previously demonstrated in cats with FIP, it can be presumed that the substitution M1058L correlates with the presence of FIP. FCoV was detected in low concentration in tissues of control animals, confirming the ability of FCoV to spread systemically. The fact that no negative controls were included in the IHC protocol could potentially lead to an underestimation of the sensitivity of the RT-qPCR.
Is macular pigment optical density really involved in fixation preference?
Authors: Erkan Turan Kadriye , Cankaya Ali Bulent , Taylan Sekeroglu Hande , Inam Onur , Karahan Sevilay 
Published: March 2018

Purpose: To evaluate macular pigment optical density in healthy children and to compare the values with those of strabismic children with respect to fixation preference. Methods: The study recruited 54 healthy and 41 strabismic children. Two groups were matched in terms of gestational age, birth weight, and body mass index. All participants underwent complete ophthalmological evaluation and macular pigment optical density measurement and filled a self-reported food frequency questionnaire. Strabismic children were categorized according to fixation preference. Results: The mean age was 9.87 ± 2.39 years in healthy children and 9.07 ± 2.07 years in children with strabismus (p = 0.091). Mean macular pigment optical density was 0.23 ± 0.25 in healthy eyes and 0.25 ± 0.27 in non-preferred eyes of strabismic children (p = 0.964). Macular pigment optical density was significantly higher in preferred eyes of strabismic children (0.43 ± 0.34) compared to non-preferred eyes (p = 0.004) and healthy eyes (p = 0.001). There was a difference of macular pigment optical density between both eyes in patients with grades 1, 2, and 3 fixation preference, whereas patients with grade 4 preference had similar macular pigment optical density in both eyes (p = 0.008). There was a statistically significant positive correlation between macular pigment optical density in preferred eyes and body mass index (r = 0.354, p = 0.023). Conclusion: Preferred eyes of children with strabismus seem to have higher macular pigment optical density readings. This difference may emerge from the higher tendency of recognizing the flicker stimulus while preferred eye is under testing. Similar macular pigment optical density in healthy and non-preferred eyes and the fact that both lower than preferred eyes remain unexplained. It should be kept in mind that macular pigment optical density results should be carefully interpreted and macular pigment optical density in cases with strabismus should be further investigated.
Complications of cataract surgery in eyes filled with silicone oil
Authors: Kanclerz Piotr , Grzybowski Andrzej , Schwartz Stephen G , Lipowski Paweł 
Published: March 2018

Introduction: The aim of the study was to evaluate complications of cataract surgery in eyes filled with silicone oil. Methods: This retrospective, noncomparative, consecutive case series analyzed medical files of patients with eyes filled with silicone oil undergoing cataract surgery. Phacoemulsification with posterior chamber intraocular lens implantation was conducted with or without concurrent silicone oil removal. Results: In this study, 121 eyes of 120 patients were included. In 32 eyes (26.4%) with evident silicone oil microemulsification or silicone oil–associated open-angle glaucoma, silicone oil was removed prior to phacoemulsification through a pars plana incision and no cases of posterior capsular rupture occurred during the subsequent cataract surgery. In the remaining 89 eyes, phacoemulsification was performed with silicone oil in the vitreous cavity. In these eyes, the rate of posterior capsular rupture was 9/89 (10.1%) and the rate of silicone oil migration into the anterior chamber through an apparently intact posterior capsule was 5/89 (5.6%). In 94 eyes (77.7%), an intraocular lens was inserted into the capsular bag, in 3 eyes (2.5%) into the sulcus, and in 1 eye (0.8%) a transscleral suturing was performed. Conclusions: In this series, complications related to the silicone oil were not uncommon during cataract surgery. In the majority of patients without evident silicone oil microemulsification or silicone oil–associated open-angle glaucoma, cataract surgery and posterior chamber intraocular lens implantation were performed while leaving the silicone oil in place.
Long-term follow-up of cryopreserved amniotic membrane transplant during strabismus reoperations: Up 85 months’ follow-up
Authors: Kassem Rehab Rashad , Kamal Ahmed Mostafa , El-Mofty Randa Mohamed Abdel-Moneim , Elhilali Hala Mostafa 
Published: March 2018

Purpose: To evaluate the long-term effect of cryopreserved human amniotic membrane transplant during strabismus reoperations. Methods: A total of 15 patients with persistent strabismus were included in a prospective study to evaluate the effect of wrapping the extra-ocular muscles with cryopreserved amniotic membrane during strabismus reoperations. The study end-point was the last follow-up visit. A successful outcome was defined as 0–10∆ of horizontal tropia and 0–4∆ of vertical tropia, with no limitation of ductions exceeding −1. A cosmetically acceptable outcome was defined as a tropia of 0–15∆. Results: Maximum follow-up was 85 months (mean: 25.4 ± 25.5 months). At the last follow-up visit, a successful outcome was achieved in 46.7%, a cosmetically acceptable outcome was achieved in 66.7%, and the mean ocular deviation angles improved from 38.60 ± 14.63∆, preoperatively, to 10.6 ± 11.08∆. Motility limitation on the final follow-up visit exceeded −1 in only 4/180 muscles (2.2%). Conclusion: The effect of cryopreserved amniotic membrane transplantation on the success of strabismus reoperations was moderate in terms of ocular alignment. Its effect was more pronounced in terms of ocular motility. The latter better reflects the level of adhesions. No long-term complications were documented, denoting safety of cryopreserved amniotic membrane usage during strabismus reoperations.