bluuebunny/crossref_metadata_2025_split huggingface dataset:
Case-control investigation of occupational exposure to chlorinated solvents and non-Hodgkin’s lymphoma
Authors: Callahan Catherine L , Stewart Patricia A , Friesen Melissa C , Locke Sarah , De Roos Anneclaire J , Cerhan James R , Severson Richard K , Rothman Nathaniel , Purdue Mark P 
Published: March 2018

ObjectivesAlthough many studies have investigated the association between trichloroethylene (TCE) exposure and non-Hodgkin’s lymphoma (NHL), less is known about other chlorinated solvents. We extended our previous analysis of occupational TCE exposure in a multicentre population-based case-control study of NHL to investigate associations with five additional chlorinated solvents: 1,1,1,-trichloroethane, carbon tetrachloride, chloroform, methylene chloride and perchloroethylene.MethodsCases (n=1189) and controls (n=982) provided detailed information on their occupational histories and workplace exposure to chlorinated solvents for selected occupations using job-specific interview modules. An industrial hygienist used this information and a review of the literature to assess occupational exposure to chlorinated solvents. We computed ORs and 95% CIs for different exposure metrics, with the unexposed group as the referent. We also computed ORs by NHL subtype.ResultsHigh cumulative hours exposed to carbon tetrachloride was associated with NHL (>520 hours: OR 1.9; 95% CI 1.0 to 3.6; Ptrend=0.04). This association remained after restricting to jobs with high-intensity exposure (OR 2.0; 95% CI 1.1 to 3.8; P=0.03) and ≥90% exposure probability (OR 2.1; 95% CI 1.0 to 4.3; P=0.03), adjusting for TCE (OR 2.1; 95% CI 1.0– to 4.1; P=0.04) and incorporating a 15-year lag (OR 1.9; 95% CI 1.0 to 3.6; P=0.06). The other evaluated chlorinated solvents were not associated with NHL.ConclusionsThis is the first study using high-quality quantitative exposure assessment methods to identify a statistically significant elevated association between occupational exposure to carbon tetrachloride and NHL. Our findings, although limited by a small number of exposed cases, offer evidence that carbon tetrachloride may be a lymphomagen.
Fostering inclusion, keeping the net neutral
Authors: Tims Jodi , Reed Daniel A. 
Published: March 2018

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http://cacm.acm.org/blogs/blog-cacm
ACM-W chair Jodi Tims offers ways everyone can promote inclusiveness, while Daniel A. Reed assesses the debate over Net neutrality.
Protumor Steering of Cancer Inflammation by p50 NF-κB Enhances Colorectal Cancer Progression
Authors: Porta Chiara , Ippolito Alessandro , Consonni Francesca Maria , Carraro Lorenzo , Celesti Giuseppe , Correale Carmen , Grizzi Fabio , Pasqualini Fabio , Tartari Silvia , Rinaldi Maurizio , Bianchi Paolo , Balzac Fiorella , Vetrano Stefania , Turco Emilia , Hirsch Emilio , Laghi Luigi , Sica Antonio 
Published: March 2018

Abstract
Although tumor-associated macrophages (TAM) display a M2-skewed tumor-promoting phenotype in most cancers, in colorectal cancer, both TAM polarization and its impact remain controversial. We investigated the role of the M2-polarizing p50 NF-κB subunit in orchestrating TAM phenotype, tumor microenvironment composition, and colorectal cancer progression. We first demonstrated, by parallel studies in colitis-associated cancer (CAC) and in genetically driven ApcMin mouse models, that the p50-dependent inhibition of M1-polarized gut inflammation supported colorectal cancer development. In accordance with these studies, p50–/– mice displayed exacerbated CAC with fewer and smaller tumors, along with enhanced levels of M1/Th1 cytokines/chemokines, including IL12 and CXCL10, whose administration restrained CAC development in vivo. The inflammatory profile supporting tumor resistance in colons from p50–/– tumor bearers correlated inversely with TAM load and positively with both recruitment of NK, NKT, CD8+ T cells and number of apoptotic tumor cells. In agreement, myeloid-specific ablation of p50 promoted tumor resistance in mice, whereas in colorectal cancer patients, a high number of p50+ TAMs at the invasive margin was associated with decreased IL12A and TBX21 expression and worse postsurgical outcome. Our findings point to p50 involvement in colorectal cancer development, through its engagement in the protumor activation of macrophages, and identify a candidate for prognostic and target therapeutic intervention. Cancer Immunol Res; 6(5); 578–93. ©2018 AACR.
Early and One-Year Outcomes of Acute Stroke in the Industrial Region of Poland During the Decade 2006–2015: The Silesian Stroke Registry
Authors: Gierlotka Marek , Labuz-Roszak Beata , Wojtyniak Bogdan , Lasek-Bal Anetta , Zdrojewski Tomasz , Adamczyk-Sowa Monika , Chwojnicki Kamil , Skrzypek Michal , Ciesla Daniel , Gasior Mariusz 
Published: March 2018

<b><i>Background:</i></b> Poland, classified as a high-income country, is still considered to have a high cardiovascular risk population. During the last decade, the standards of care in acute stroke (AS) had markedly improved; thus, we aimed to assess whether and how it translated into early and late outcomes. <b><i>Methods:</i></b> Silesian Stroke Registry was created from the administrative database of the public, obligatory, health ­insurer in Poland. The AS cases were selected based on primary diagnosis coded in ICD-10 as I60-I64 for years 2006–2015 (<i>n</i> = 120,844). Index hospitalization together with data on re-hospitalizations, procedures, ambulatory visits, rehabilitation and all-cause deaths in a 1-year follow-up were analyzed. <b><i>Results:</i></b> The rates of admissions per 100,000 adult population varied between 41–47 for haemorrhagic and 257–275 for ischaemic stroke with substantial decrease in almost all age groups except for the oldest patients. In ischaemic stroke, thrombolytic therapy raised from 0 to 8.8% in 2015, along with significant trends of decreasing 30-day (from 20 to 16%) and 12-month (from 35 to 31%) case fatality. In haemorrhagic stroke, case fatality had not changed. After ischaemic stroke, 12-month readmissions due to AS declined from 11–12% in 2006–2009 to 9% in 2010–2014. The percentage of patients benefiting from rehabilitation increased from 24 to 32%. <b><i>Conclusions:</i></b> In a large population of industrial province, we showed recent, positive trends in AS admissions, treatment and 1-year outcomes. Development of stroke unit networks and increase in thrombolytic treatment were at least in part responsible for survival improvement and reduction of recurrence of AS. However, case-fatality and stroke recurrence remain high compared to those of other developed countries.
Rainbow trout personality: individual behavioural variation in juvenile Oncorhynchus mykiss
Authors: Elias Ashley , Thrower Frank , Nichols Krista M. 
Published: March 2018

AbstractWe evaluated the variation in dispersal, exploration, and aggression across time in juvenile progeny produced from wild caught rainbow trout (Oncorhynchus mykiss) at a critical developmental shift associated with the highest mortality in fish. By testing multiple ecologically relevant behaviours repeatedly in the same individuals, we simultaneously tested multiple hypotheses regarding personality, plasticity, and behavioural syndromes to better understand the innate behavioural variation in a population containing both migratory and resident life histories. There were consistent behavioural differences, or personality, between individuals across time, for dispersal, aggression, and exploration, unrelated to size or sex. The significant repeatabilities (0.10–0.46) indicate that these traits are potentially heritable. Also, we found both habituation in all behaviours and significant differences between individuals in the rate of that habituation, despite no evidence of a behavioural syndrome. The identification of this individual level variation is a step towards understanding which heritable traits selection could influence.
Age and growth of the common wall lizard, Podarcis muralis (Laurenti, 1768)
Authors: Eroğlu Ali İhsan , Bülbül Ufuk , Kurnaz Muammer , Odabaş Yasemin 
Published: March 2018

Abstract
The present study was designed to compare the life history traits of two Podarcis muralis populations located at sites of different elevation. The age at maturity was similar in both populations, whereas longevity was found to be lower in the lowland one (Dereköy). The males and females of both populations had a similar snout-vent length (SVL) and mean age. Sexual size dimorphism (SSD) was weak in the highland population, males being slightly larger than females, whereas a strong male-biased SSD was observed in the lowland one. The growth coefficient (k) and growth rates were similar in both populations. This study indicates that the age at maturation (2-3 years) and growth rates (2.37 mm/year) are similar in two populations of P. muralis exposed to different climatic and environmental conditions. Longevity was slightly higher in the highland population (16 years) compared to the lowland one (14 years).
Desire for Self-healing
Authors: Lau Ngar-sze 
Published: March 2018

Abstract
This practice report describes how Chinese meditators understand the “four foundations of mindfulness” (satipaṭṭhāna, sinianzhu 四念住) as a remedy for both mental and physical suffering. In the tradition of Theravāda Buddhism, satipaṭṭhāna is particularly recognized as the core knowledge for understanding the relationship between mind and body, and the core practice leading to liberation from suffering. Based on interviews with Chinese meditation practitioners, this study develops three main themes concerning how they have alleviated afflictions through the practice of satipaṭṭhāna. The first theme highlights how practitioners learn to overcome meditation difficulties with “right attitude.” The second theme is about practicing awareness with “six sense doors” open in order to facilitate the balance of the “five faculties.” The third theme explores how practitioners cultivate daily life practice through an understanding of the nature of mind and body as impermanent and as not-self. This paper details how these themes and embodied practices of satipaṭṭhāna constitute ways of self-healing for urban educated Buddhists in the contemporary Chinese context.
Interdecadal Variability of the Warm Arctic and Cold Eurasia Pattern and Its North Atlantic Origin
Authors: Sung Mi-Kyung , Kim Seon-Hwa , Kim Baek-Min , Choi Yong-Sang 
Published: March 2018

ABSTRACTThis study investigates the origin of the interdecadal variability in the warm Arctic and cold Eurasia (WACE) pattern, which is defined as the second empirical orthogonal function of surface air temperature (SAT) variability over the Eurasian continent in Northern Hemisphere winter, by analyzing the Twentieth Century Reanalysis dataset. While previous studies highlight recent enhancement of the WACE pattern, ascribing it to anthropogenic warming, the authors found that the WACE pattern has experienced a seemingly periodic interdecadal variation over the twentieth century. This long-term variation in the Eurasian SAT is attributable to the altered coupling between the Siberian high (SH) and intraseasonal Rossby wave emanating from the North Atlantic, as the local wave branch interacts with the SH and consequentially enhances the continental temperature perturbation. It is further identified that these atmospheric circulation changes in Eurasia are largely controlled by the decadal amplitude modulation of the climatological stationary waves over the North Atlantic region. The altered decadal mean condition of stationary wave components brings changes in local baroclinicity and storm track activity over the North Atlantic, which jointly change the intraseasonal Rossby wave generation and propagation characteristics as well. With simple stationary wave model experiments, the authors confirm how the altered mean flow condition in the North Atlantic acts as a source for the growth of the Rossby wave that leads to the change in the downstream WACE pattern.
Tolerogenic properties of the Fc portion of IgG and its relevance to the treatment and management of hemophilia
Authors: Blumberg Richard S. , Lillicrap David ,   the IgG Fc Immune Tolerance Group
Published: March 2018

AbstractHemophilia, or inherited genetic deficiencies in coagulation factors, results in uncontrolled bleeding requiring replacement therapy with recombinant proteins given preventively or on demand. However, a major problem with these approaches is the potential for development of immune responses to the administered proteins due to the underlying genetic deficiency of the factor(s) throughout life. As such, there is great interest in developing strategies that avoid immunogenicity and induce immune tolerance. Recently, recombinant factor VIII (rFVIII) and rFIX fused to the crystallizable fragment (Fc) domain of immunoglobulin G (IgG) have been developed as therapeutic agents for hemophilia A and B, respectively. Although it is well known that the possession of an Fc domain confers IgG’s longer-lasting circulating half-life, it is not generally appreciated that the Fc domain also confers immunoregulatory properties that are associated with the induction of tolerance. Here, we review some of the latest advances in our understanding of the tolerogenic abilities of IgG Fc and the impact of Fc-fusion proteins of rFVIII on the treatment of hemophilia.
Antitumor Activity of Nivolumab in Recurrent and Metastatic Nasopharyngeal Carcinoma: An International, Multicenter Study of the Mayo Clinic Phase 2 Consortium (NCI-9742)
Authors: Ma Brigette B.Y. , Lim Wan-Teck , Goh Boon-Cher , Hui Edwin P. , Lo Kwok-Wai , Pettinger Adam , Foster Nathan R. , Riess Jonathan W. , Agulnik Mark , Chang Alex Y.C. , Chopra Akhil , Kish Julie A. , Chung Christine H. , Adkins Douglas R. , Cullen Kevin J. , Gitlitz Barbara J. , Lim Dean W. , To Ka-Fai , Chan K.C. Allen , Lo Y.M. Dennis , King Ann D. , Erlichman Charles , Yin Jun , Costello Brian A. , Chan Anthony T.C. 
Published: March 2018

Purpose This multinational study evaluated the antitumor activity of nivolumab in nasopharyngeal carcinoma (NPC). Tumor and plasma-based biomarkers were investigated in an exploratory analysis. Patients and Methods Patients with multiply pretreated recurrent or metastatic NPC were treated with nivolumab until disease progression. The primary end point was objective response rate (ORR) and secondary end points included survival and toxicity. The expression of programmed death-ligand 1 (PD-L1) and human leukocyte antigens A and B in archived tumors and plasma clearance of Epstein-Barr virus DNA were correlated with ORR and survival. Results A total of 44 patients were evaluated and the overall ORR was 20.5% (complete response, n = 1; partial response, n = 8). Nine patients received nivolumab for > 12 months (20%). The 1-year overall survival rate was 59% (95% CI, 44.3% to 78.5%) and 1-year progression-free survival (PFS) rate was 19.3% (95% CI, 10.1% to 37.2%). There was no statistical correlation between ORR and the biomarkers; however, a descriptive analysis showed that the proportion of patients who responded was higher among those with PD-L1 positive tumors (> 1% expression) than those with PD-L1-negative tumors. The loss of expression of one or both human leukocyte antigen class 1 proteins was associated with better PFS than when both proteins were expressed (1-year PFS, 30.9% v 5.6%; log-rank P = .01). There was no association between survival and PD-L1 expression or plasma Epstein-Barr virus DNA clearance. There was no unexpected toxicity to nivolumab. Conclusion Nivolumab has promising activity in NPC and the 1-year overall survival rate compares favorably with historic data in similar populations. Additional evaluation in a randomized setting is warranted. The biomarker results were hypothesis generating and validation in larger cohorts is needed.
Exercise Training Mitigates Multisystem Deconditioning during Bed Rest
Authors: PLOUTZ-SNYDER LORI L. , DOWNS MEGHAN , GOETCHIUS ELIZABETH , CROWELL BRENT , ENGLISH KIRK L. , PLOUTZ-SNYDER ROBERT , RYDER JEFFREY W. , DILLON EDGAR LICHAR , SHEFFIELD-MOORE MELINDA , SCOTT JESSICA M. 
Published: March 2018

ABSTRACT

Introduction
This study investigated the safety and effectiveness of a new integrated aerobic and resistance exercise training prescription (SPRINT) using two different sets of exercise equipment: a suite of large International Space Station–like exercise equipment similar to what is found on the International Space Station and a single device with aerobic and resistance exercise capability in the spaceflight analog of bed rest (BR).

Methods
Subjects (n = 34) completed 70 d of 6° head down tilt BR: 9 were randomized to remain sedentary (CONT), 9 to exercise training using traditional equipment (EX), 8 to exercise using traditional equipment and low-dose testosterone supplementation (ExT), and 8 to exercise using a combined resistance and aerobic flywheel device. Peak aerobic capacity, ventilatory threshold, cardiac morphology and function (echocardiography), muscle mass (magnetic resonance imaging) and strength/power (isokinetic, leg press, and vertical jump), and bone health (bone mineral density, blood and urine bone markers) were assessed before and after BR.

Results
The SPRINT protocol mitigated BR-induced muscle and cardiac deconditioning regardless of the exercise device used. Molecular markers of bone did not change in the CONT or EX groups. Peak aerobic capacity was maintained from pre- to post-BR in all exercise groups similarly, whereas significant declines were observed in the CONT group (~10%). Significant interaction effects between the CONT group and all EX groups were observed for muscle performance including leg press total work, isokinetic upper and lower leg strength, vertical jump power, and maximal jump height as well as muscle size.

Conclusions
This is the first trial to evaluate multisystem deconditioning and the role of an integrated exercise countermeasure. These findings have important implications for the design and implementation of exercise-based countermeasures on future long-duration spaceflight missions.
Impact of Medicaid Managed Care on Illinois's Acute Health Services Expenditures for Adults With Intellectual and Developmental Disabilities
Authors: Yamaki Kiyoshi , Wing Coady , Mitchell Dale , Owen Randall , Heller Tamar 
Published: March 2018

Abstract
States have increasingly transitioned Medicaid enrollees with disabilities from fee-for-service (FFS) to Medicaid Managed Care (MMC), intending to reduce state Medicaid spending and to provide better access to health services. Yet, previous studies on the impact of MMC are limited and findings are inconsistent. We analyzed the impact of MMC on costs by tracking Illinois's Medicaid acute health services expenditures for adults with intellectual and developmental disabilities (IDD) living in the community (n = 1,216) before and after their transition to MMC. Results of the difference-in-differences (DID) regression analysis using an inverse propensity score weight (IPW) matched comparison group (n = 1,134) design suggest that there were no significant state Medicaid cost savings in transitioning people with IDD from FFS to MMC.
Implementation of MHLFF based low power pulse triggered flip flop
Authors: Verma Shreya , Usharani Tunikipati , Iswariya S , Godavarthi Bhavana 
Published: March 2018

The present research paper proposes to implement a low power pulse-triggered flip-flop. The proposed design is MHLFF (modified hybrid latch flip-flop). In MHLFF method, the pulse generator will be altered concerning illustration inverters what’s more a pasquinade transistor. This technique will be comparative should understood kind about flip flop what’s more it utilizes a static lock structure. Should succeed Most exceedingly bad situation delay issue brought on Eventually Tom's perusing discharging way comprise from claiming three stacked transistor MHLFF may be presented. We can minimize the power and delay when compared to the existing models i.e, CDFF and SCDFF. The circuit was implementing using Cadence Virtuoso tool in 90-nm and 45-nm technology.
Perception on faculty academic relationship management in higher education with reference to self financing engineering colleges
Authors: Selvakumar V. , Maran K. , Sankar S. 
Published: March 2018

The study aims to find out the faculty perceptions in higher education towards academic relationship management. The researcher selected 363 respondents by convenience sampling technique among the faculty members working in engineering colleges in the district of Chennai, Kanchipuram and Thiruvallur districts of Tamilnadu for this study. This study is to find out the perceptional difference in relationship management due to demographic factors–gender, age, designation and marital status and contributing factors- team work, Job stress and work environment. The study revealed that major faculty members perceive work environment, teamwork, leadership, career growth are the key dimensions that has influence on relationship management if these dimensions are perceived positively. Moreover, job stress has a negative impact on the perception of faculty academic relationship by the faculty members.
Mutual fund investors perception in India-a study
Authors: Udhayasankar R. , Maran K. 
Published: March 2018

Mutual fund is four decades old in India. It was started by UTI during the year 1964 with few schemes for small investors. During this short span of time it has made tremendous growth in Indian small investors. But now a day’s its volume of investors and sources of investment also growing tremendous level. Moreover mutual fund scheme have added new dimension to overcome financial risk of small investors and also in fund raising capacity of corporate sectors. Mutual fund investors can diversify even more by purchasing different kind of stocks which will helps to spreading out investors’ money across different types of derivative instruments and hence it reduces the risk tremendously up to certain extent and it is automatically diversify in a predetermined category of investments. This serves bridge work between small investors and corporate sectors likewise considering those points in this paper is an attempt to know the investors’ perceptions towards selected mutual funds. This paper makes an attempt to identify various factors affecting perception of investors regarding investment in mutual funds. The findings will helpful to identify the investors’ interest base and factors clearly and it reveals that the investors consider mutual funds as flexible investment option and it creates interest of investment among small investors.
Study of the mechanical performance and analysis of hybrid natural snake grass-jute-glass fiber strengthened polyester composite
Authors: Thiruvasagam C. , Prabagaran S. , Suresh P. 
Published: March 2018

The research paper involves fiber composites form a special category materials that are contributing to present swaping of manufactured hybrid which finds traditional and non traditional applications. The study explains which are accentuates and optimizing for the recently recognized snake grass standard materials. In this article, the prospecting performance characterization of SG fiber is selected and contrasted as per the ASTM standard. This study additionally manages the examination apply different phenomena of this stages in Jute and snake as fortifications utilized index ended a try. Experiments have been conducted on normal Filaments, snake grass, Glass Fiber and Jute to analyse their Mechanical properties. The common strands are orchestrated in the flat and vertical heading as transferred quality on all sides. Microstructural analysis of these hybrid composite is observed using Scanning Electron Microscope that reveals bonding and Filament breaksge, Voids and Fiber decover which are further investigated.