bluuebunny/crossref_metadata_2025_split huggingface dataset:
Gravitomagnetism and pulsar beam precession near a Kerr black hole
Authors: Kocherlakota Prashant , Joshi Pankaj S , Bhattacharyya Sudip , Chakraborty Chandrachur , Ray Alak , Biswas Sounak 
Published: September 2019

ABSTRACT
A rotating black hole causes the spin axis of a nearby pulsar to precess due to geodetic and gravitomagnetic frame-dragging effects. The aim of our theoretical work here is to explore how this spin precession can modify the rate at which pulses are received on Earth. Towards this end, we obtain the complete evolution of the beam vectors of pulsars moving on equatorial circular orbits in the Kerr space–time, relative to asymptotic fixed observers. We proceed to establish that such spin precession effects can significantly modify observed pulse frequencies and, in specific, we find that the observed pulse frequency rises sharply as the orbit shrinks, potentially providing a new way to locate horizons of Kerr black holes, even if observed for a very short time period. We also discuss implications for detections of sub-millisecond pulsars, pulsar nulling, quasi-periodic oscillations, multiply peaked pulsar Fourier profiles, and how Kerr black holes can potentially be distinguished from naked singularities.
Using large-scale structure data and a halo model to constrain generalized dark matter
Authors: Thomas Daniel B , Kopp Michael , Markovič Katarina 
Published: September 2019

ABSTRACTConstraints on the properties of the cosmological dark matter have previously been obtained in a model-independent fashion using the generalized dark matter (GDM) framework. Here we extend that work in several directions: We consider the inclusion of WiggleZ matter power spectrum data (MPS), and show that this improves the constraints on the two perturbative GDM parameters, $c^2_\mathrm{ s}$ and $c^2_\text{vis}$, by a factor of 3, for a conservative choice of wavenumber range. A less conservative choice can yield an improvement of up to an order of magnitude compared to previous constraints. In order to examine the robustness of this result we develop a GDM halo model (HM) to explore how non-linear structure formation could proceed in this framework, since currently GDM has only been defined perturbatively and only linear theory has been used when generating constraints. We then examine how the HM affects the constraints obtained from the MPS data. The less-conservative wavenumber range shows a significant difference between linear and non-linear modelling, with the latter favouring GDM parameters inconsistent with ΛCDM, underlining the importance of careful non-linear modelling when using this data. We also use this HM to establish the robustness of previously obtained constraints, particularly those that involve weak gravitational lensing of the cosmic microwave background. Additionally, we show how the inclusion of neutrino mass as a free parameter affects previous constraints on the GDM parameters.
The nuclear environment of the NLS1 Mrk 335: Obscuration of the X-ray line emission by a variable outflow
Authors: Parker M L , Longinotti A L , Schartel N , Grupe D , Komossa S , Kriss G , Fabian A C , Gallo L , Harrison F A , Jiang J , Kara E , Krongold Y , Matzeu G A , Pinto C , Santos-Lleó M 
Published: September 2019

ABSTRACT
We present XMM–Newton, NuSTAR, Swift, and Hubble Space Telescope observations of the Narrow-line Seyfert 1 galaxy Mrk 335 in a protracted low state in 2018 and 2019. The X-ray flux is at the lowest level so far observed, and the extremely low continuum flux reveals a host of soft X-ray emission lines from photoionized gas. The simultaneous UV flux drop suggests that the variability is intrinsic to the source, and we confirm this with broad-band X-ray spectroscopy. The dominance of the soft X-ray lines at low energies and distant reflection at high energies, is therefore due to the respective emission regions being located far enough from the X-ray source that they have not yet seen the flux drop. Between the two XMM–Newton spectra, taken 6 months apart, the emission line ratio in the O vii triplet changes drastically. We attribute this change to a drop in the ionization of intervening warm absorption, which means that the absorber must cover a large fraction of the line emitting region, and extend much further from the black hole than previously assumed. The HST spectrum, taken in 2018, shows that new absorption features have appeared on the blue wings of C iii*, Ly α, N v, Si iv, and C iv, likely due to absorbing gas cooling in response to the low flux state.
Phosphorylation of Drosophila CENP-A on serine 20 regulates protein turn-over and centromere-specific loading
Authors: Huang Anming , Kremser Leopold , Schuler Fabian , Wilflingseder Doris , Lindner Herbert , Geley Stephan , Lusser Alexandra 
Published: September 2019

AbstractCentromeres are specialized chromosomal regions epigenetically defined by the presence of the histone H3 variant CENP-A. CENP-A is required for kinetochore formation which is essential for chromosome segregation during mitosis. Spatial restriction of CENP-A to the centromere is tightly controlled. Its overexpression results in ectopic incorporation and the formation of potentially deleterious neocentromeres in yeast, flies and in various human cancers. While the contribution of posttranslational modifications of CENP-A to these processes has been studied in yeast and mammals to some extent, very little is known about Drosophila melanogaster. Here, we show that CENP-A is phosphorylated at serine 20 (S20) by casein kinase II and that in mitotic cells, the phosphorylated form is enriched on chromatin. Importantly, our results reveal that S20 phosphorylation regulates the turn-over of prenucleosomal CENP-A by the SCFPpa-proteasome pathway and that phosphorylation promotes removal of CENP-A from ectopic but not from centromeric sites in chromatin. We provide multiple lines of evidence for a crucial role of S20 phosphorylation in controlling restricted incorporation of CENP-A into centromeric chromatin in flies. Modulation of the phosphorylation state of S20 may provide the cells with a means to fine-tune CENP-A levels in order to prevent deleterious loading to extra-centromeric sites.
Low temperature isothermal amplification of microsatellites drastically reduces stutter artifact formation and improves microsatellite instability detection in cancer
Authors: Daunay Antoine , Duval Alex , Baudrin Laura G , Buhard Olivier , Renault Victor , Deleuze Jean-François , How-Kit Alexandre 
Published: September 2019

AbstractMicrosatellites are polymorphic short tandem repeats of 1–6 nucleotides ubiquitously present in the genome that are extensively used in living organisms as genetic markers and in oncology to detect microsatellite instability (MSI). While the standard analysis method of microsatellites is based on PCR followed by capillary electrophoresis, it generates undesirable frameshift products known as ‘stutter peaks’ caused by the polymerase slippage that can greatly complicate the analysis and interpretation of the data. Here we present an easy multiplexable approach replacing PCR that is based on low temperature isothermal amplification using recombinase polymerase amplification (LT-RPA) that drastically reduces and sometimes completely abolishes the formation of stutter artifacts, thus greatly simplifying the calling of the alleles. Using HT17, a mononucleotide DNA repeat that was previously proposed as an optimal marker to detect MSI in tumor DNA, we showed that LT-RPA improves the limit of detection of MSI compared to PCR up to four times, notably for small deletions, and simplifies the identification of the mutant alleles. It was successfully applied to clinical colorectal cancer samples and enabled detection of MSI. This easy-to-handle, rapid and cost-effective approach may deeply improve the analysis of microsatellites in several biological and clinical applications.
A prognostic model to personalize monitoring regimes for patients with incidental asymptomatic meningiomas
Authors: Islim Abdurrahman I , Kolamunnage-Dona Ruwanthi , Mohan Midhun , Moon Richard D C , Crofton Anna , Haylock Brian J , Rathi Nitika , Brodbelt Andrew R , Mills Samantha J , Jenkinson Michael D 
Published: September 2019

Abstract

Background
Asymptomatic meningioma is a common incidental finding with no consensus on the optimal management strategy. We aimed to develop a prognostic model to guide personalized monitoring of incidental meningioma patients.

Methods
A prognostic model of disease progression was developed in a retrospective cohort (2007–2015), defined as: symptom development, meningioma-specific mortality, meningioma growth or loss of window of curability. Secondary endpoints included non-meningioma-specific mortality and intervention.

Results
Included were 441 patients (459 meningiomas). Over a median of 55 months (interquartile range, 37–80), 44 patients had meningioma progression and 57 died (non-meningioma-specific). Forty-four had intervention (at presentation, n = 6; progression, n = 20; nonprogression, n = 18). Model parameters were based on statistical and clinical considerations and included: increasing meningioma volume (hazard ratio [HR] 2.17; 95% CI: 1.53–3.09), meningioma hyperintensity (HR 10.6; 95% CI: 5.39–21.0), peritumoral signal change (HR 1.58; 95% CI: 0.65–3.85), and proximity to critical neurovascular structures (HR 1.38; 95% CI: 0.74–2.56). Patients were stratified based on these imaging parameters into low-, medium- and high-risk groups and 5-year disease progression rates were 3%, 28%, and 75%, respectively. After 5 years of follow-up, the risk of disease progression plateaued in all groups. Patients with an age-adjusted Charlson comorbidity index ≥6 (eg, an 80-year-old with chronic kidney disease) were 15 times more likely to die of other causes than to receive intervention at 5 years following diagnosis, regardless of risk group.

Conclusions
The model shows that there is little benefit to rigorous monitoring in low-risk and older patients with comorbidities. Risk-stratified follow-up has the potential to reduce patient anxiety and associated health care costs.
Designing ionic channels in novel carbons for electrochemical energy storage
Authors: Ye Jianglin , Simon Patrice , Zhu Yanwu 
Published: September 2019

Abstract
Tremendous efforts have been dedicated to developing high-performance energy storage devices based on the micro- or nano-manipulation of novel carbon electrodes, as certain nanocarbons are perceived to have advantages such as high specific surface areas, superior electric conductivities, excellent mechanical properties and so on. In typical electrochemical electrodes, ions are intercalated/deintercalated into/from the bulk (for batteries) or adsorbed/desorbed on/from the surface (for electrochemical capacitors). Fast ionic transport, significantly determined by ionic channels in active electrodes or supporting materials, is a prerequisite for the efficient energy storage with carbons. In this report, we summarize recent design strategies for ionic channels in novel carbons and give comments on the promising features based on those carbons towards tailorable ionic channels.
Termite colonies from mid-Cretaceous Myanmar demonstrate their early eusocial lifestyle in damp wood
Authors: Zhao Zhipeng , Yin Xiangchu , Shih Chungkun , Gao Taiping , Ren Dong 
Published: September 2019

Abstract
Insect eusociality is characterized by cooperative brood care, reproductive division of labour and multiple generations of adults within a colony. The morphological specializations of the different termite castes from Burmese amber were recently reported, indicating the termites possessed advanced sociality in the mid-Cretaceous. Unfortunately, all the reported Cretaceous termites are individually preserved, which does not cover the behaviours of the cooperative brood care and multiple generations of adults in the nests of the Cretaceous termites. Herein, we report three eusocial aggregations from colonies of the oldest known Stolotermitidae, Cosmotermesgen. nov., in 100 Ma mid-Cretaceous Burmese amber. One large aggregation, comprising 8 soldiers, 56 workers/pseudergates and 25 immatures of different instars, additionally presents the behaviours of cooperative brood care and overlapping generations. Furthermore, taphonomic evidence indicates Cosmotermes most probably dwelled in damp/rotting wood, which provides a broader horizon of the early societies and ecology of the eusocial Cosmotermes.
Exceeding WHO Framework Convention on Tobacco Control (FCTC) Obligations: Nepal Overcoming Tobacco Industry Interference to Enact a Comprehensive Tobacco Control Policy
Authors: Bhatta Dharma N , Bialous Stella , Crosbie Eric , Glantz Stanton 
Published: September 2019

AbstractBackgroundThe tobacco industry works to block, delay, and weaken national tobacco control legislation to implement the WHO Framework Convention on Tobacco Control (FCTC). This article reviews how Nepal overcame industry opposition and to a comprehensive tobacco control law implementing the FCTC.MethodsWe triangulated newspaper articles and policy documents with key informant interviews.ResultsWith the support of international health groups, local tobacco control advocates worked with policymakers in Nepal to pass a comprehensive tobacco control law that exceeded FCTC obligations. The tobacco industry exploited a time of political transition to block consideration by Parliament, arranged and sponsored foreign tours for legislators, made death threats to tobacco control advocates and their families, and argued for the economic importance of tobacco farms. Despite strong interference from Health, and Law and Justice ministers, a 2009 Supreme Court ruling helped tobacco control advocates secure a comprehensive tobacco control law in 2011 that included rotating pictorial health warning labels covering 75% of both sides of cigarette packages, 100% smoke free public places and workplaces, private homes and vehicles, and a tobacco advertising, promotion, and sponsorship ban.ConclusionsAdvocates in developing countries should utilize Nepal's experience to reject tobacco industry offers of compromise and continue educating politicians and legislators to generate political support to pass a comprehensive tobacco control law. Technical and financial support from international agencies, and effective collaboration and coordination of civil societies, and utilization of domestic litigation are helpful in LMICs where governance is weak (the abstract in Nepali is available as a Supplementary Material).ImplicationsThe tobacco industry exploited a time of political transition in Nepal in its effort to block comprehensive tobacco control policy in Parliament by sponsoring foreign tours of legislatures, making death threats to tobacco control advocates and their families, and arguing for the economic importance of tobacco farms. Tobacco control advocates used litigation to raise awareness and educate legislators and promote strong legislation with the involvement of international health groups. Technical and financial support from international agencies, and effective collaboration and coordination of civil societies, and utilization of domestic litigation are helpful in LMICs where governance is weak.
A yeast display immunoprecipitation screen for targeted discovery of antibodies against membrane protein complexes
Authors: Lajoie Jason M , Cho Yong Ku , Frost Dustin , Bremner Samantha , Li Lingjun , Shusta Eric V 
Published: September 2019

Abstract
Yeast display immunoprecipitation is a combinatorial library screening platform for the discovery and engineering of antibodies against membrane proteins using detergent-solubilized membrane fractions or cell lysates as antigen sources. Here, we present the extension of this method for the screening of antibodies that bind to membrane protein complexes, enabling discovery of antibodies that target antigens involved in a functional protein-protein interaction of interest. For this proof-of-concept study, we focused on the receptor-mediated endocytosis machinery at the blood-brain barrier, and adaptin 2 (AP-2) was chosen as the functional interaction hub. The goal of this study was to identify antibodies that bound to blood-brain barrier (BBB) membrane protein complexes containing AP-2. Screening of a nonimmune yeast display antibody library was carried out using detergent-solubilized BBB plasma membranes as an antigen pool, and antibodies that could interact with protein complexes containing AP-2 were identified. Downstream characterization of isolated antibodies confirmed targeting of proteins known to play important roles in membrane trafficking. This functional yeast display immunoprecipitation screen may be applied to other systems where antibodies against other functional classes of protein complexes are sought.
Spontaneous generation of spin current from the vacuum by strong electric fields
Authors: Huang Xu-Guang , Matsuo Mamoru , Taya Hidetoshi 
Published: September 2019

AbstractWe discuss spontaneous spin current generation from the vacuum by strong electric fields as a result of interplay between the Schwinger mechanism and a spin–orbit coupling. By considering a homogeneous slow strong electric field superimposed by a fast weak transverse electric field, we explicitly evaluate the vacuum expectation value of a spin current (the Bargmann–Wigner spin current) by numerically solving the Dirac equation. We show that a non-vanishing spin current polarized in the direction perpendicular to the electric fields flows mostly in the longitudinal direction. We also find that a relativistic effect due to helicity conservation affects the direction/polarization of a spin current.
Thermal fluctuations to the thermodynamics of a non-rotating BTZ black hole
Authors: Nadeem-ul-islam  , Ganai Prince A , Upadhyay Sudhaker 
Published: September 2019

Abstract
We discuss the effect of small statistical thermal fluctuations around the equilibrium of the thermodynamics of a small non-rotating BTZ black hole. This is done by evaluating the leading-order corrections to the thermodynamical equations of state, namely entropy, free energy, internal energy, pressure, enthalpy, Gibbs free energy, and specific heat, quantitatively. In order to analyze the effects of perturbations on the thermodynamics, we plot various graphs and compare corrected and non-corrected thermodynamic quantities with respect to the event horizon radius of a non-rotating BTZ black hole. We also derive the first-order corrections to isothermal compressibility.
Identifying evidence of effectiveness in the co-creation of research: a systematic review and meta-analysis of the international healthcare literature
Authors: Halvorsrud Kristoffer , Kucharska Justyna , Adlington Katherine , Rüdell Katja , Brown Hajdukova Eva , Nazroo James , Haarmans Maria , Rhodes James , Bhui Kamaldeep 
Published: September 2019

Abstract

Background
To investigate and address the evidence gap on the effectiveness of co-creation/production in international health research.

Methods
An initial systematic search of previous reviews published by 22 July 2017 in Medline, Embase, PsycINFO, Scopus and Web of Science. We extracted reported aims, elements and outcomes of co-creation/production from 50 reviews; however, reviews rarely tested effectiveness against intended outcomes. We therefore checked the reference lists in 13 included systematic reviews that cited quantitative studies involving the public/patients in the design and/or implementation of research projects to conduct meta-analyses on their effectiveness using standardized mean difference (SMD).

Results
Twenty-six primary studies were included, showing moderate positive effects for community functions (SMD = 0.56, 95%CI = 0.29–0.84, n = 11) and small positive effects for physical health (SMD = 0.25, 95%CI = 0.07–0.42, n = 9), health-promoting behaviour (SMD = 0.14, 95%CI = 0.03–0.26, n = 11), self-efficacy (SMD = 0.34, 95%CI = 0.01–0.67, n = 3) and health service access/receipt (SMD = 0.36, 95%CI = 0.21–0.52, n = 12). Non-academic stakeholders that co-created more than one research stage showed significantly favourable mental health outcomes. However, co-creation was rarely extended to later stages (evaluation/dissemination), with few studies specifically with ethnic minority groups.

Conclusions
The co-creation of research may improve several health-related outcomes and public health more broadly, but research is lacking on its longer term effects.
Quantitative Easing and Equity Prices: Evidence from the ETF Program of the Bank of Japan
Authors: Barbon Andrea , Gianinazzi Virginia 
Published: September 2019

Abstract
Since the introduction of its quantitative and qualitative easing program in 2013, the Bank of Japan has been increasing its holdings of Japanese equity through large-scale purchases of index-linked ETFs, to lower risk premiums. We exploit the cross-sectional heterogeneity of the supply shock to identify a positive and persistent impact on stock prices, consistent with a portfolio balance channel. The evidence suggests that long-run demand curves for stocks are downward sloping with unitary price elasticity. We show that the purchases of ETFs tracking the price-weighted Nikkei 225 generate pricing distortions relative to a value-weighted benchmark.
Received April 13, 2018; editorial decision July 18, 2019 by Editor Thierry Foucault. Authors have furnished an Internet Appendix, which is available on the Oxford University Press Web site next to the link to the final published paper online.
Cretaceous beetles (Insecta: Coleoptera) in amber: the palaeoecology of this most diverse group of insects
Authors: Peris David , Rust Jes 
Published: September 2019

AbstractBeetles, the most successful group of invertebrates on Earth, have a worldwide distribution and an outstanding fossil record. In addition, they are well known as inclusions in fossil resin. In historical studies of fossil material, specimens were often named and described without placing the taxa in an ecological context. However, the research philosophy for fossil beetles has changed over the past few years. In this article, we summarize the palaeoecological interpretations of fossil beetles from Cretaceous ambers, which includes species from 69 families, most of which were described during the last 3 years. By analysing current habits of those families, we argue that saproxylicity was the most common feeding strategy for these fossil beetles. More specifically, fungivorous species appear to dominate. In contrast, we find only anecdotal evidence for the presence of wood-boring groups, and it is thus necessary to identify alternative abiotic or biotic processes that are responsible for the copious resin production at this time. Finally, the recent description of some beetles as gymnosperm pollinators during the Cretaceous lends more weight to the importance of amber studies in addressing the role of beetles in the evolution of pollination strategies.
Updated concepts in the diagnosis and management of community-acquired pneumonia
Authors: Hunton Ryan 
Published: September 2019

ABSTRACT
Pneumonia accounts for about 1 million hospitalizations each year in the United States. It is the number one cause of death from infectious disease and eighth leading cause of death in the United States. This article reviews recent updates in best practices for diagnosing and managing pneumonia in the ED or primary care practice. Despite developments in the diagnosis of pneumonia, vital signs and chest examination findings can and should guide clinical management. Chest radiography is routinely used to diagnose pneumonia. However, a negative chest radiograph should not replace clinical impression. In immunocompetent patients with community-acquired pneumonia, the CURB-65 decision rule has a role in identifying high-risk patients, including those who will require ICU admission and a critical care intervention.