bluuebunny/crossref_metadata_2025_split huggingface dataset:
Gradual Release of Sensitive Data under Differential Privacy
Authors: Koufogiannis Fragkiskos , Han Shuo , Pappas George J. 
Published: February 2018

We introduce the problem of releasing private data under differential privacy when the privacy level is subject to change over time. Existing work assumes that privacy level is determined by the system designer as a fixed value before private data is released. For certain applications, however, users may wish to relax the privacy level for subsequent releases of the same data after either a re-evaluation of the privacy concerns or the need for better accuracy. Specifically, given a database containing private data, we assume that a response y1 that preserves \( \epsilon _1\)-differential privacy has already been published. Then, the privacy level is relaxed to \( \epsilon _2\), with \( \epsilon _2 > \epsilon _1\), and we wish to publish a more accurate response y2 while the joint response (y1,y2) preserves \( \epsilon _2\)-differential privacy. How much accuracy is lost in the scenario of gradually releasing two responses y1 and y2 compared to the scenario of releasing a single response that is \( \epsilon _2\)-differentially private? Our
results consider the more general case with multiple privacy level relaxations and show that there exists a composite mechanism that achieves no loss
in accuracy.
We consider the case in which the private data lies within Rn with an adjacency relation induced by the \( \ell _1\)-norm, and we initially focus on mechanisms that approximate identity queries. We show that the same accuracy can be achieved in the case of gradual release through a mechanism whose outputs can be described by a lazy Markov stochastic process. This stochastic process has a closed form expression and can be efficiently sampled. Moreover, our results extend beyond identity queries to a more general family of privacy-preserving mechanisms. To this end, we demonstrate the applicability of our tool to multiple scenarios including Google’s project RAPPOR, trading of private data, and controlled transmission of private data in a social network. Finally, we derive similar results for the approximated differential privacy.
A study of Some Hormones and Antioxidant ‎Systems Disturbances in Older Men
Authors: Al-Saadi Reem Abdul-Raheem , Al-Watify Dakhel Ghani 
Published: February 2018

Ageing is a physiological phenomenon that manifested itself with disturbances of many homeostatic regulating mechanisms of the body . The present study was conducted and employed to investigate two major systems( hormones and antioxidant systems) that can be implicated in progress of aging .The total number of subjects included in the present study was fifty (50) healthy men and classified according to their ages into two groups, the first group included 25 younger men (control group) and their ages ranged between 21 to 30 years old whereas the second group included 25 older men and their ages were between 61 to 70 years old. Data obtained from this study indicated a significant decrease(p<0.05) in the levels of thyroid stimulating hormone (TSH) which is associated with marked elevation (p<0.05) of triiodothyronine(T3) and tetraiodothyronine(T4) of older men when compared with younger men. In regard to levels of cortisol and testosterone hormones were significantly decreased (p<0.05) in aged men when matched with their counterparts of younger men. Concerning concentrations of malondehyde (MDA) ,a final product of lipid peroxidation, confirmed a remarkable elevation (p<0.05) in older men compared to younger men and these results were associated with significant lowering (p<0.05) in the activities of antioxidant components including glutathione peroxidase (GPX), reduced glutathione (GSH) and catalase . In addition , there are no significant correlations(p>0.05) occurring among hormones( testosterone , T3) and glutathione peroxidase and of malondehyde . From these results ,one can be concluded that with ageing there are many disturbances and fluctuations of hypothalamic-adrenal and thyroid axis that accompanied with drop of essential antioxidant components that may be lead to suppress of defense against free radicals and the present study concluded that the changes occurring in studied hormones have not relations and effects on the antioxidant systems.
Genotipos de frijol negro opaco resistentes a sequía terminal
Authors: Tosquy-Valle Oscar Hugo , López-Salinas Ernesto , Francisco-Nicolás Néstor , Acosta-Gallegos Jorge Alberto , Villar-Sánchez Bernardo 
Published: February 2018

En Veracruz, la sequía terminal es el factor abiótico que más limita la producción de frijol Phaseolus vulgaris L. en el sistema de producción de humedad residual. Los objetivos de la investigación fueron: clasificar genotipos de frijol negro opaco por su resistencia a sequía e identificar los de mayor eficiencia en rendimiento en condiciones de riego y sequía terminal. En invierno-primavera de 2013, se condujeron dos experimentos en Cotaxtla, Veracruz; uno con riego completo y el otro con suspensión de riego a partir del inicio de floración. Se evaluaron 22 líneas y las variedades Negro INIFAP, Negro Tacaná y Negro Jamapa, en diseño experimental bloques al azar con tres repeticiones. Se cuantificó días a madurez fisiológica, producción de materia seca sin grano, vainas por planta, semillas por vaina, peso de 100 semillas y rendimiento de grano. Como estimadores de eficiencia se utilizaron los índices de susceptibilidad a sequía (ISS) y de eficiencia relativa del rendimiento (IER). El rendimiento y la cantidad de vainas por planta fueron las características más afectadas por la sequía terminal, con reducciones promedio de 41.39 y 29.97%. Con ISS menores a 0.81, NCB-229, SCN-2, Jamapa Plus y SEN-70 fueron los genotipos más resistentes a sequía, mientras que X0233-159-2, X02-33-147-2, B-98311, MBSF-14729 y Negro Jamapa, los más susceptibles. CIAT-103-25, SCN 2, SEN 70, NGO 17-99 y NCB 229, mostraron la mayor eficiencia en rendimiento con riego y sequía (IER mayor a 1.35), en tanto que X02-33-159-2, B-98311, MBSF-14729 y Negro Jamapa, tuvieron la menor eficiencia productiva.
Caracterización físico-química de sustratos orgánicos para producción de pepino (Cucumis sativus L.) bajo sistema protegido
Authors: Galindo Pardo Flor Valeria , Fortis Hernández Manuel , Preciado Rangel Pablo , Trejo Valencia Radames , Segura Castruita Miguel Ángel , Orozco Vidal Jorge Arnaldo 
Published: February 2018

El presente trabajo pretende aportar información sobre el uso de sustratos orgánicos elaborados a partir de estiércol bovino tratado para la producción de pepino. El trabajo se realizó en Invernadero durante el año 2011 en el Instituto Tecnológico de Torreón (ITT), Torreón, Coahuila. El diseño experimental fue completamente al azar; considerando cuatro tratamientos con cuatro repeticiones: vermicompost + arena (20:80 v/v); estiércol solarizado + arena (20:80); vermicompost + estiércol solarizado + arena (10:10:80) y un tratamiento testigo (solución steiner). Las mezclas de sustratos se formularon en base a volumen (v/v), utilizando bolsas de polietileno negro de 15 kg de peso. El material genético fue el híbrido Hisham 1110-EZ. Las variables evaluadas en planta fueron altura, peso fresco y seco, rendimiento, calidad de fruto, sólidos solubles y análisis químico foliar; en el sustrato se evaluaron parámetros físicos, químicos y microbiológicos. Los resultados indicaron respuesta significativa en altura, rendimiento y en el análisis del tejido vegetal, así como en CE y pH. El rendimiento de pepino fue mayor con la utilización de la solución Steiner (9.87 kg m-2); la mezcla de arena más vermicompost (80:20) obtuvo el mayor rendimiento de los sustratos orgánicos con un rendimiento de 8.45 kg m-2. Éstos resultados permiten suponer que la utilización del sustrato de arena con vermicompost, como medio de crecimiento y nutrición, podría permitir reducir la fertilización tradicional, lo cual se considera una mejora en los sistemas de producción orgánica bajo invernadero.
Pengaruh Anggaran Partisipatif terhadap Kinerja pada Lembaga Keuangan Syariah yang di Mediasi Keadilan Persepsian dan Komitmen
Authors: Santoso Selamet Eko Budi , W Wage 
Published: February 2018

Penelitian ini menguji apakah penganggaran partisipatif mempengaruhi kinerja, dan apakah pengaruh tersebut dimediasi oleh keadilan persepsian dan komitmen terhadap tujuan. Penelitian ini dilakukan pada Lembaga Keuangan Syariah, yaitu Baitulmal Wattamwil (BMT), di Kabupaten Banyumas.Penelitian ini menggunakan sampel manajer dan kepala bagian keuangan lembaga keuangan mikro syariah. Data dikumpulkan dengan cara pengisian kuesioner. Metode statistik yang digunakan untuk menguji masing-masing hipotesis adalah Structural Equation Modelling Partial Least Square (SEM PLS) menggunakan WARP PLS.Penelitian ini menemukan bahwa: (1) penganggaran partisipatif positif mempengaruhi kinerja manajerial; (2) pengaruh tersebut dimediasi sebagian oleh keadilan prosedural dan komitmen terhadap tujuan.
Kesepian Pada Middle Age yang Melajang (Studi Fenomenologis Tentang Tipe Kesepian)
Authors: Wardani Dyah Putri , Septiningsih Dyah Siti 
Published: February 2018

Penelitian ini bertujuan untuk mengkaji tipe kesepian pada middle age yang masih melajang di Purwokerto.Penelitian ini menggunakan metode penelitian kualitatif dengan pendekatan fenomenologis. Hasil penelitian menunjukkan bahwa informan 1 berjenis kelamin pria menunjukkan 7 tipe kesepian yang dialami yaitu kesepian emosional (sedang melakukan tahap pendekatan dengan lawan jenis), mengalami interpersonal loneliness (merindukan wanita yang pernah dekat, setelah putus dengan wanita tersebut banyak menjalin hubungan dengan lawan jenis), kesepian kosmik (belum memiliki wanita yang cocok untuk dinikahi, memiliki pemikiran bahwa menjalin hubungan dengan wanita yang berjarak jauh tidak akan berjalan lancar), kesepian kognitif (jarang mencurahkan hati dengan orang lain), kesepian psikologikal (pengalaman masa lalu berpengaruh untuk kehidupan saat ini sehingga merasa kecewa, menyesal, merasa bersalah dan merasa kena kualat), kesepian perilaku (berbagai kegiatan dilakukan sendiri), dan kesepian sosial (tidak memiliki peran dalam masyarakat). Informan 2 berjenis kelamin pria menunjukkan 4 tipe kesepian yang dialami yaitu kesepian emosional (ingin memiliki hubungan yang serius dengan lawan jenis), kesepian kosmik (belum memilki wanita yang cocok untuk dinikahi, merasa tidak mungkin menjalin hubungan dengan wanita karena merasa belum mapan dari segi ekonomi), kesepian kognitif (jarang mencurahkan hati dengan orang lain, lebih memilih Allah SWT sebagai tempat curahan hatinya) dan kesepian perilaku (berbagai kegiatan dilakukan sendiri). Informan 3 berjenis kelamin wanitamenunjukkan 4 tipe kesepian yang dialami yaitu kesepian emosional (merasa kurang mendapatkan kasih sayang dari keluarga dan belum terpenuhi), kesepian kognitif (hanya mencurahkan hati dengan kakak), kesepian sosial (tidak memiliki peran dalam masyarakat, keadaan lingkungan tempat tinggal sepi), dan culture shock (merasa kesulitan menyesuaikan diri saat berada dilingkungan baru). Kata Kunci : Tipe Kesepian, Middle Age, Lajang.
Perbedaan Kecerdasan Emosi Antara Perawat Laki-Laki dan Perawat Perempuan
Authors: Nugroho Satrio , Dwiyanti Retno 
Published: February 2018

Penelitian ini bertujuan mengetahui perbedaan dan melihat tingkat kecerdasan emosi antara perawat laki-laki dan perawat perempuan di Rumah Sakit Wijayakusuma Purwokerto. Subjek pada penelitian ini berjumlah 94 perawat di Rumah Sakit Wijayakusuma Purwokerto yang terbagi menjadi dua kelompok yaitu 35 perawat laki-laki dan 59 perawat perempuan. Metode pengumpulan data yang digunakan pada penelitian ini adalah metode kuesioner dengan instrumen skala kecerdasan emosi. Hasil uji validitas melalui try out terpakai terhadap 94 perawat diperoleh koefisien validitas yang bergerak dari mulai 0,316 sampai 0,741 dengan standar Azwar sebesar 0,3 dan taraf signifikansi sebesar 5% (0,05). Sedangkan hasil uji reliabilitas skala kecerdasan emosi diperoleh nilai a sebesar 0,915. Berdasarkan hasil uji hipotesis dengan menggunakan teknik uji-t diperoleh t hitung sebesar 4.879 dengan nilai probabilitas 0,000. Oleh karena itu t tabel dengan df (n-2) sebesar 92 dan menggunakan taraf signifikansi 1% (0,01) yaitu sebesar 2,630, maka t hitung> t tabel yaitu (4,879 > 2,630) dan nilai probabilitas lebih kecil dari 1% (0,01) yaitu (0,000< 0,01). Hasil uji mean, maka diketahui bahwa mean untuk kecerdasan emosi perawat laki-laki yaitu 149.06 lebih besar dari mean kecerdasan emosi perempuan yaitu 135.63. Dengan standar deviasi (SD) kecerdasan emosi perawat laki-laki yaitu 14.138 dan standar deviasi (SD) kecerdasan emosi perempuan yaitu 12.117. Dengan demikian, maka dapat disimpulkan bahwa hipotesis pada penelitian ini adalah diterima, berarti ada perbedaan yang signifikan kecerdasan emosi antara perawat laki-laki dengan perawat perempuan dan kecerdasan emosi perawat laki-laki lebih tinggi daripada perawat perempuan di Rumah Sakit Wijayakusuma Purwokerto. Kata Kunci : Kecerdasan Emosi, Perawat Laki-laki, Perawat Perempuan.
Jogos como tecnologias educacionais para o ensino de genética: a aprendizagem por meio do lúdico
Authors: Silva Meiridiane Ribeiro da , Antunes Adriana Maria 
Published: February 2018

A genética é uma das áreas da biologia em que os alunos demonstram maior grau de dificuldade, por ser complexa e trazer conteúdos de difícil assimilação. O presente trabalho teve como objetivo elaborar o jogo intitulado “Jogando com a genética”, bem como avaliar a eficácia dessa tecnologia educacional no ensino de genética. O jogo informatizado de perguntas e respostas acerca dos principais conceitos de genética foi criado em Microsoft Office Power Point, considerando a essência das metodologias lúdicas. A proposta pedagógica foi realizada em uma turma do 3° ano do Ensino Médio do colégio XX. Os resultados da pesquisa foram analisados por meio de questionários pré-teste e pós-teste e de observações in loco. Verificou-se que os jogos lúdicos associados ao método tradicional de ensino possibilitam entendimento dos conteúdos, participação e interação dos alunos nas aulas. A pesquisa permitiu caracterizar um novo recurso didático que pode ser reproduzido e usado por outros educadores no ensino de genética.
İlkokul Dördüncü Sınıf Öğrencilerinin Ceza ve Kural Kavramlarına İlişkin Algılarının Metaforlarla Analiz Edilmesi
Authors: AKAR Tuba , ÖĞRETİR ÖZÇELİK Ayşe Dilek 
Published: February 2018

Bu araştırmanın
amacı, İlkokul dördüncü sınıf çocuklarının ceza ve kural kavramlarına ait
kullandıkları metaforları ortaya çıkarmaktır. Araştırma örneklemini Sinop
merkez ilçe bünyesinde yer alan Osmaniye İlkokulu, Korucuk İlkokulu, Atatürk
İlkokulu ve Gazi İlkokulunda öğrenim gören 261 öğrenci
oluşturmaktadır.Araştırmada veri toplamak amacıyla, araştırmaya katılan
çocukların ceza ve kural kavramlarına dair sahip oldukları algıları ortaya
çıkarmak amacıyla açık uçlu bir anket formu düzenlenmiş; anket formunda
çocuklara “Ceza............. gibidir; çünkü…….” ve “Kural............. gibidir;
çünkü…….” cümlelerini tamamlamaları
istenmiştir.Öğrencilerin ceza ve kural kavramlarına ilişkin düşünceleri içerik
analizi tekniği ile çözümlenmiştir. Araştırma sonucunda, üretilen ceza metaforların kaynaklarına
bakıldığında; engellenme (hapishane), balon, acı biber, spor, kötü gibi
kavramların en çok kullanıldığı görülmüştür. Öğrenciler tarafından üretilen
kural ile ilgili metaforların kaynaklarına bakıldığında ise trafik, okul,
müzik, ev ve spor gibi kavramların öğrenciler tarafından en çok algılandıkları
tespit edilmiştir. İlkokul 4.sınıf öğrencilerinin ceza ve kural kavramlarını
soyut düşünemedikleri için yaşamsal olarak maruz kaldıkları deneyimler
üzerinden ilişkilendirdikleri anlaşılmıştır. Ancak bu temel deneyimler üzerine
çocuklara kavramsal şemalarını oluşturmaları adına kavramların fonksiyonlarına
ilişkin formel bilgilere pek yer verilmediği belirlenmiştir.
MLN8237 treatment in an orthoxenograft murine model for malignant peripheral nerve sheath tumors
Authors: Payne Russell , Mrowczynski Oliver D. , Slagle-Webb Becky , Bourcier Alexandre , Mau Christine , Aregawi Dawit , Madhankumar Achuthamangalam B. , Lee Sang Y. , Harbaugh Kimberly , Connor James , Rizk Elias B. 
Published: February 2018

OBJECTIVEMalignant peripheral nerve sheath tumors (MPNSTs) are soft-tissue sarcomas arising from peripheral nerves. MPNSTs have increased expression of the oncogene aurora kinase A, leading to enhanced cellular proliferation. This makes them extremely aggressive with high potential for metastasis and a devastating prognosis; 5-year survival estimates range from a dismal 15% to 60%. MPNSTs are currently treated with resection (sometimes requiring limb amputation) in combination with chemoradiation, both of which demonstrate limited effectiveness. The authors present the results of immunohistochemical, in vitro, and in vivo analyses of MLN8237 for the treatment of MPNSTs in an orthoxenograft murine model.METHODSImmunohistochemistry was performed on tumor sections to confirm the increased expression of aurora kinase A. Cytotoxicity analysis was then performed on an MPNST cell line (STS26T) to assess the efficacy of MLN8237 in vitro. A murine orthoxenograft MPNST model transfected to express luciferase was then developed to assess the efficacy of aurora kinase A inhibition in the treatment of MPNSTs in vivo. Mice with confirmed tumor on in vivo imaging were divided into 3 groups: 1) controls, 2) mice treated with MLN8237, and 3) mice treated with doxorubicin/ifosfamide. Treatment was carried out for 32 days, with imaging performed at weekly intervals until postinjection day 42. Average bioluminescence among groups was compared at weekly intervals using 1-way ANOVA. A survival analysis was performed using Kaplan-Meier curves.RESULTSImmunohistochemical analysis showed robust expression of aurora kinase A in tumor cells. Cytotoxicity analysis revealed STS26T susceptibility to MLN8237 in vitro. The group receiving treatment with MLN8237 showed a statistically significant difference in tumor size compared with the control group starting at postinjection day 21 and persisting until the end of the study. The MLN8237 group also showed decreased tumor size compared with the doxorubicin/ifosfamide group at the conclusion of the study (p = 0.036). Survival analysis revealed a significantly increased median survival in the MLN8237 group (83 days) compared with both the control (64 days) and doxorubicin/ifosfamide (67 days) groups. A hazard ratio comparing the 2 treatment groups showed a decreased hazard rate in the MLN8237 group compared with the doxorubicin/ifosfamide group (HR 2.945; p = 0.0134).CONCLUSIONSThe results of this study demonstrate that MLN8237 is superior to combination treatment with doxorubicin/ifosfamide in a preclinical orthoxenograft murine model. These data have major implications for the future of MPNST research by providing a robust murine model as well as providing evidence that MLN8237 may be an effective treatment for MPNSTs.
Ligament augmentation for prevention of proximal junctional kyphosis and proximal junctional failure in adult spinal deformity
Authors: Safaee Michael M. , Deviren Vedat , Dalle Ore Cecilia , Scheer Justin K. , Lau Darryl , Osorio Joseph A. , Nicholls Fred , Ames Christopher P. 
Published: February 2018

OBJECTIVEProximal junctional kyphosis (PJK) is a well-recognized, yet incompletely defined, complication of adult spinal deformity surgery. There is no standardized definition for PJK, but most studies describe PJK as an increase in the proximal junctional angle (PJA) of greater than 10°–20°. Ligament augmentation is a novel strategy for PJK reduction that provides strength to the upper instrumented vertebra (UIV) and adjacent segments while also reducing junctional stress at those levels.METHODSIn this study, ligament augmentation was used in a consecutive series of adult spinal deformity patients at a single institution. Patient demographics, including age; sex; indication for surgery; revision surgery; surgical approach; and use of 3-column osteotomies, vertebroplasty, or hook fixation at the UIV, were collected. The PJA was measured preoperatively and at last follow-up using 36-inch radiographs. Data on change in PJA and need for revision surgery were collected. Univariate and multivariate analyses were performed to identify factors associated with change in PJA and proximal junctional failure (PJF), defined as PJK requiring surgical correction.RESULTSA total of 200 consecutive patients were included: 100 patients before implementation of ligament augmentation and 100 patients after implementation of this technique. The mean age of the ligament augmentation cohort was 66 years, and 67% of patients were women. Over half of these cases (51%) were revision surgeries, with 38% involving a combined anterior or lateral and posterior approach. The mean change in PJA was 6° in the ligament augmentation group compared with 14° in the control group (p < 0.001). Eighty-four patients had a change in PJA of less than 10°. In a multivariate linear regression model, age (p = 0.016), use of hook fixation at the UIV (p = 0.045), and use of ligament augmentation (p < 0.001) were associated with a change in PJA. In a separate model, only ligament augmentation (OR 0.193, p = 0.012) showed a significant association with PJF.CONCLUSIONSLigament augmentation represents a novel technique for the prevention of PJK and PJF. Compared with a well-matched historical cohort, ligament augmentation is associated with a significant decrease in PJK and PJF. These data support the implementation of ligament augmentation in surgery for adult spinal deformity, particularly in patients with a high risk of developing PJK and PJF.
Actigraphy Detects Greater Intra-Individual Variability During Gait in Non-Manifesting LRRK2 Mutation Carriers
Authors: van den Heuvel Lieneke , Lim Andrew S. , Visanji Naomi P. , Huang Jana , Ghate Taneera , Mestre Tiago A. , AlDakheel Amaal , Connolly Barbara S. , Gasca-Salas Carmen , Kern Drew S. , Jain Jennifer , Slow Elizabeth J. , Pondal Margarita , Faust-Socher Achinoam , Rogaeva Ekaterina , Tomlinson George , Lang Anthony E. , Marras Connie 
Published: February 2018

Background: With recent advances in the search for disease-modifying therapies for Parkinson’s disease (PD) the importance of identifying prodromal markers becomes greater. Non-manifesting LRRK2 mutation carriers (NMC) are at risk for developing PD, and provide a population in which to identify possible markers. Objective: The aim of this study was to test the hypothesis that NMC have differences in daily activity, fragmentation of sleep, arm swing asymmetry, and movement variability during walking, detectable by actigraphy, as compared to matched control subjects. Methods: Eleven NMC, fourteen PD patients (4 LRRK2-PD, 10 idiopathic PD (iPD)), and twenty-nine controls wore wristbands containing an accelerometer for seven days, and performed a daily walking task. Outcome measures included daily activity, fragmentation of activity, fragmentation of sleep, arm swing asymmetry during walking, and intra-individual variability. Results: Compared to healthy controls, both NMC and LRRK2/iPD showed higher intra-individual variability in activity during walking compared to healthy controls. Individuals with LRRK2-PD/iPD, but not NMC, tend to have lower activity levels, more arm swing asymmetry and less increase of arm swing with transition from slow to faster walking speed compared to healthy controls. Conclusion: Higher intra-individual variability of gait-associated movements might be a useful biomarker of prodromal PD. These results encourage replication in a larger sample and longitudinal analysis is warranted.