bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identification of Prolificacy‐Related Differentially Expressed Proteins from Sheep (Ovis aries) Hypothalamus by Comparative Proteomics
Authors: Zhang Zhuangbiao , Tang Jishun , Di Ran , Liu Qiuyue , Wang Xiangyu , Gan Shangquan , Zhang Xiaosheng , Zhang Jinlong , Chen Wei , Hu Wenping , Chu Mingxing 
Published: May 2019

AbstractReproduction, as a physiologically complex process, can significantly affect the development of the sheep industry. However, a lack of overall understanding to sheep fecundity has long blocked the progress in sheep breeding and husbandry. In the present study, the aim is to identify differentially expressed proteins (DEPs) from hypothalamus in sheep without FecB mutation in two comparison groups: polytocous (PF) versus monotocous (MF) sheep at follicular phase and polytocous (PL) versus monotocous (ML) sheep at luteal phase. Totally 5058 proteins are identified in sheep hypothalamus, where 22 in PF versus MF, and 39 proteins in PL versus ML are differentially expressed, respectively. A functional analysis is then conducted including Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway analysis to reveal the potential roles of these DEPs. The proteins ENSOARP00000020097, ENSOARP00000006714, growth hormone (GH), histone deacetylase 4 (HDAC4), and 5′‐3′ exoribonuclease 2 (XRN2) in PF versus MF, and bcl‐2‐associated athanogene 4 (BAG4), insulin‐like growth factor‐1 receptor (IGF1R), hydroxysteroid 11‐beta dehydrogenase 1 (HSD11B1), and transthyretin (TTR) in PL versus ML appear to modulate reproduction, presumably by influencing the activities of gonadotropin‐releasing hormone (GnRH). This study provides an alternative method to identify DEPs associated with sheep prolificacy from the hypothalamus. The mass spectrometry data are available via ProteomeXchange with identifier PXD013822.
Enhancing the settling time estimation of a class of fixed‐time stable systems
Authors: Aldana‐López Rodrigo , Gómez‐Gutiérrez David , Jiménez‐Rodríguez Esteban , Sánchez‐Torres Juan Diego , Defoort Michael 
Published: May 2019

SummaryIn this paper, we provide a new nonconservative upper bound for the settling time of a class of fixed‐time stable systems. To expose the value and the applicability of this result, we present four main contributions. First, we revisit the well‐known class of fixed‐time stable systems, to show the conservatism of the classical upper estimate of its settling time. Second, we provide the smallest constant that the uniformly upper bounds the settling time of any trajectory of the system under consideration. Third, introducing a slight modification of the previous class of fixed‐time systems, we propose a new predefined‐time convergent algorithm where the least upper bound of the settling time is set a priori as a parameter of the system. At last, we design a class of predefined‐time controllers for first‐ and second‐order systems based on the exposed stability analysis. Simulation results highlight the performance of the proposed scheme regarding settling time estimation compared to existing methods.
Polymorphism of Palladium(II) Complexes : Crystal Structure Determination, Luminescence Properties, Hirshfeld Surface Analyses and DFT/TD‐DFT Studies
Authors: Seyfi Sara , Alizadeh Robabeh. , Ganji Masoud D. , Amani Vahid 
Published: May 2019

AbstractTwo luminescent polymorphs based on a new Pd(II) complex [Pd(mtzt)2(en)] (mtzt=1‐methyl‐1H‐1,2,3,4‐tetrazole‐5‐thiol and en=ethylenediamine) have been synthesized and characterized by FTIR, UV/Vis, elemental analysis,1HNMR and single‐crystal X‐ray diﬀraction analysis. The X‐ray structural analysis indicated that in the structures of these polymorphs Pd(II) cation is four‐coordinated in a distorted square planer configuration by two tetrazole rings in the cis‐positions, two nitrogen atoms of chelated ethylenediamine ligand. The dihedral angles between the planes of the tetrazole rings of polymorphs (1) and (2) are 72.01 and 77.70°, respectively. Moreover, in these polymorphs, intermolecular interactions C−H…N, C−H…S, and N−H…N hydrogen bonds, are effective in the stabilization of the crystal structures. The present study reports a detailed analysis of Hirshfeld surfaces, facilitating a comparison of intermolecular interactions in the supramolecular structure. The geometries of polymorphs (1) and (2) are optimized with B3LYP−D3/TZVP method, and analyzed with natural bond orbital (NBO), then their UV/Vis spectra are calculated with time‐dependent density functional theory (TD‐DFT) method. The IR spectroscopy was performed using VEDA4 software and compared with the experimental values. Quantum chemical parameters are: such as EHOMO, ELUMO, energy gap, chemical hardness (η), and dipole moment (μ), and the frontier molecular orbital properties.
Hexyltriphenylphosphonium Bromide as an Absolutely Chemoselective Ionic Liquid Catalyst in the Three‐Component Reaction of Aryl Aldehydes, Acetophenones and Malononitrile
Authors: Bahrami Kiumars , Khodaei Mohammad M. , Batooie Nasim , Hosseinzadeh Nouraddin , Foroumadi Alireza 
Published: May 2019

AbstractHexyltriphenylphosphonium bromide (HTPB) is used as an efficient ionic liquid catalyst in the chemoselective addition of malononitrile to carbonyl group moiety of chalcones through the three‐component reaction of aryl aldehydes, acetophenone derivatves, and malononitrile to produce (E)‐2‐(1,3‐diarylallylidene)malononitriles at ambient temperature. The method is simple, solvent‐free, environmentally friendly, and gives excellent yields in a short reaction times.
Effect of pH Variations on the Properties of Cyclodextrin‐Calixarene Nanosponges
Authors: Di Vincenzo Antonella , Russo Marco , Cataldo Salvatore , Milea Demetrio , Pettignano Alberto , Lo Meo Paolo 
Published: May 2019

AbstractThe pH‐responsive properties of cyclodextrin‐calixarene nanosponge co‐polymeric materials have been investigated. In particular, ISE‐H+ potentiometric titrations were carried out in order to evaluate the acid‐base properties and the actual amount of ionizable sites present in the materials. Moreover, the relevant pH‐dependent adsorption abilities were evaluated towards a set of selected model organic pollutant molecules by means of adsorption tests and by studying the corresponding adsorption isotherms. The latter ones could be suitably described by means of the Freundlich model. The whole of the experimental results enabled us to clarify some general aspects of the microscopic behavior of the nanosponges considered.
Porous Graphitic Carbon Nitride Synthesized via Using Carbon Nanotube as a Novel Recyclable Hard Template for Efficient Visible Light Photocatalytic Organic Pollutant Degradation
Authors: Chen Xiang , Wang Haonan , Meng Ruru , Chen Minmin 
Published: May 2019

AbstractTwo‐dimensional (2D) graphitic carbon nitride (g‐C3N4) has attracted considerable attention due to its many intriguing properties in visible light photocatalysis. However, the photocatalytic performance of g‐C3N4 is far from satisfaction partly because standard synthesis methods prepare rather dense materials with low specific surface area. Herein, we report a facile approach to prepare porous g‐C3N4 via using carbon nanotubes (CNT) as a novel hard template for the first time. Unlike other hard templates, CNT can be easily removed by ultrasonic method and recycled to produce porous g‐C3N4. The as‐prepared porous g‐C3N4 has a much higher specific surface area of 103.3 m2 g−1 than the bulk g‐C3N4 of 10.5 m2 g−1. The photocatalytic organic pollutant decomposition rate of porous g‐C3N4 is nearly 4.4 times as high as that of bulk g‐C3N4 under visible light (λ > 400 nm) irradiation. This work opens a new way to explore the sustainable, environment‐friendly preparation of high‐performance g‐C3N4 for solar energy conversion and environmental remediation, especially for large‐scale applications in industry.
Palladium/Copper Nanoalloy Supported on Carbon Nanotubes for the Electrooxidation of Methanol and Ethylene Glycol
Authors: Arulmani Subramanian , Kumar Ponnusamy Vinoth , Landi Giovanni , Anandan Sambandam 
Published: May 2019

AbstractHerein, we demonstrate the ultrasonic‐assisted synthesis of Palladium/Copper nanoalloy supported on carbon nanotubes (PdCu/CNT) towards the electro‐oxidation of methanol and ethylene glycol using Triton X‐100 as a stabilizer. Structural and morphological analysis manifests the formation of PdCu nanoalloy on the surface of CNTs. For the electrochemical comparison, PdCu on Vulcan carbon (PdCu/VC) also synthesized in the same procedure and characterized thoroughly. The electrochemical evaluations of the PdCu/CNT reveal the better mass activity of 1021.6 mA mg[pd]−1 which is 1.6‐fold higher than PdCu/VC and 5.9 times advanced than commercial Pd/C catalysts towards methanol electrooxidation. Also, for electrooxidation of ethylene glycol, the mass activity of the PdCu/CNT is more of about 1219.8 mA mg[pd]−1 which is around 1.7 times enhanced than PdCu/VC and 4.1 times improved than commercial Pd/C catalysts. Furthermore, sonochemically prepared PdCu/CNT provides improved stability up to 3600s in both methanol and ethylene glycol oxidation reactions. The accredited activity enhancement due to its unique construction of zero‐dimensional structured PdCu nanoalloy with one‐dimensional CNTs and modified electronic effect of Pd on it.
Impact of aerodynamic modelling on seakeeping performance of a floating vertical axis wind turbine
Authors: Leroy Vincent , Gilloteaux Jean‐Christophe , Lynch Mattias , Babarit Aurélien , Ferrant Pierre 
Published: May 2019

AbstractThis study focuses on the impact of the aerodynamic model on the dynamic response of a floating vertical axis wind turbine (VAWT). It compares a state‐of‐the‐art quasi‐steady double multiple streamtube (DMS) solver, a prescribed vortex wake (PVW), and a free vortex wake (FVW) solver. The aerodynamic loads acting on a bottom‐fixed VAWT and computed with the three aerodynamic solvers are compared, then the dynamic responses of the floating turbine in irregular waves and turbulent wind with the different aerodynamic solvers are compared. Differences are observed, particularly in the mean motions of the platform. Eventually, the aerodynamic damping computed by the solvers are estimated with aerodynamic simulations on the turbine with imposed surge and pitch motions. The estimated damping can then be correlated with the dynamic response amplitude of the VAWT. Substantial discrepancies are observed between the three solvers at high tip speed ratio, when the rotor is highly loaded. It is shown that the quasi‐steady DMS solver seems to give greater amplitude of motions for the floating VAWT because of strong rotor/wake interaction that are not correctly accounted for.
Cross-Cultural Comparison of the Code of the Street
Authors: Howell Simon , Kurtenbach Sebastian , Rauf Abdul , Zaman Muhammad , Zdun Steffen 
Published: May 2019

AbstractThis is one of the core chapters of this book. After describing the national peculiarities, the main findings are presented and cross-culturally compared and reflected in the context of the street code. The aspects, social space/neighborhood, street etiquette, symbols, toughness/masculinity, friends, respect, enemies, and violent perception are addressed. The goal of this approach is not just a documentation of the main findings but also a stepwise comparison of these topics in the three countries. This allows for presenting a wide range of various aspects, but also a description and discussion of similarities.
Uncovering early indicators of fixation during the concept development stage of children’s design processes
Authors: Schut Alice , Klapwijk Remke , Gielen Mathieu , van Doorn Fenne , de Vries Marc 
Published: May 2019

AbstractIn this paper, we explore the early indicators of design fixation occurring during the concept development stage of children’s design processes. This type of fixation, which we named:concept fixation, causes a blind adherence to the current (possibly unfavourable) state of a design idea. Its occurrence hampers the creative thinking processes present in a design process, which in turn stagnates the development of initial design ideas into final designs. Until now, research on design fixation has mainly focussed on creative idea generation in the early phases of the design process through analysing (intermediate) design ideas and completed artefacts. However, children’s fixation behaviours might be identified at an earlier moment through the conversations that take place in the classroom about their design ideas. To this end, we present a case study in which we explored early indicators of concept fixation of a group of 24 primary school children (ages 9–11) carrying out a co-design project. Fixation was observed through the manner in which the design teams responded to questions and comments from their peers and the client. Four categories of response behaviours indicating concept fixation emerged from the verbal data, namely: ‘band-aids’, ‘already-in-there’, ‘question-not-relevant’ and ‘it’s-not-possible’. We expect that the indicators will be helpful in identifying concept fixation during the design process, especially in an educational context. The process of identification of fixation, and reflecting on it, creates awareness. This is considered as an important step by professional designers towards guarding oneself from fixation episodes in future projects, and thus being more creative.
The response of a standardized fluid challenge during cardiac surgery on cerebral oxygen saturation measured with near-infrared spectroscopy
Authors: Holmgaard Frederik , Vistisen Simon T. , Ravn Hanne B. , Scheeren Thomas W. L. 
Published: May 2019

AbstractNear infrared spectroscopy (NIRS) has been used to evaluate regional cerebral tissue oxygen saturation (ScO2) during the last decades. Perioperative management algorithms advocate to maintain ScO2, by maintaining or increasing cardiac output (CO), e.g. with fluid infusion. We hypothesized that ScO2 would increase in responders to a standardized fluid challenge (FC) and that the relative changes in CO and ScO2 would correlate. This study is a retrospective substudy of the FLuid Responsiveness Prediction Using Extra Systoles (FLEX) trial. In the FLEX trial, patients were administered two standardized FCs (5 mL/kg ideal body weight each) during cardiac surgery. NIRS monitoring was used during the intraoperative period and CO was monitored continuously. Patients were considered responders if stroke volume increased more than 10% following FC. Datasets from 29 non-responders and 27 responders to FC were available for analysis. Relative changes of ScO2 did not change significantly in non-responders (mean difference − 0.3% ± 2.3%, p = 0.534) or in fluid responders (mean difference 1.6% ± 4.6%, p = 0.088). Relative changes in CO and ScO2 correlated significantly, p = 0.027. Increasing CO by fluid did not change cerebral oxygenation. Despite this, relative changes in CO correlated to relative changes in ScO2. However, the clinical impact of the present observations is unclear, and the results must be interpreted with caution.Trial registration:http://ClinicalTrial.gov identifier for main study (FLuid Responsiveness Prediction Using Extra Systoles—FLEX): NCT03002129.
PET Evaluation of Microglial Activation in Non-neurodegenerative Brain Diseases
Authors: Ghadery Christine , Best Laura A. , Pavese Nicola , Tai Yen Foung , Strafella Antonio P. 
Published: May 2019

AbstractPurpose of the ReviewMicroglial cell activation is an important component of neuroinflammation, and it is generally well accepted that chronic microglial activation is indicative of accumulating tissue damage in neurodegenerative conditions, particularly in the earlier stages of disease. Until recently, there has been less focus on the role of neuroinflammation in other forms of neurological and neuropsychiatric conditions. Through this review, we hope to demonstrate the important role TSPO PET imaging has played in illuminating the pivotal role of neuroinflammation and microglial activation underpinning these conditions.Recent FindingsTSPO is an 18 kDa protein found on the outer membrane of mitochondria and can act as a marker of microglial activation using nuclear imaging. Through the development of radiopharmaceuticals targeting TSPO, researchers have been able to better characterise the spatial-temporal evolution of chronic neurological conditions, ranging from the focal autoimmune reactions seen in multiple sclerosis to the Wallerian degeneration at remote parts of the brain months following acute cerebral infarction.SummaryDevelopment of novel techniques to investigate neuroinflammation within the central nervous system, for the purposes of diagnosis and therapeutics, has flourished over the past few decades. TSPO has proven itself a robust and sensitive biomarker of microglial activation and neuroimaging affords a minimally invasive technique to characterise neuroinflammatory processes in vivo.
Epidemiological, clinical, and severity characterization of sickle cell disease in a population from the Brazilian Amazon
Authors: Cesar Purim , Dhyani Anamika , Schwade Luiz Augusto , Acordi Pollyana , Albuquerque Cinthia Xerez , Nina Rejane , Paula Erich V. De , Fraiji Nelson 
Published: May 2019

Objective/background:
Sickle cell disease (SCD) is a chronic inflammatory condition caused by a point mutation in the HBB gene. Here we characterized the clinical presentation of SCD in a population from Amazonas State in northern Brazil, in order to evaluate whether the higher Amerindian ancestry observed in this relatively isolated geographic region would influence the clinical presentation of SCD.

Methods:
This was a cross-sectional study characterizing the clinical presentation of SCD patients registered at HEMOAM, Amazon, Brazil. Data were obtained using a structured questionnaire, and by a review of the medical records.

Results:
Of the 236 SCD patients listed in the historical records, 122 were included in this study. The median age was 15 years, with a male to female ratio of 52:70. The population was characterized by a high level of socioeconomic vulnerability, with only 2.1% presenting a family income above five minimum wages. Homozygous HbS (SS) was the most prevalent form of SCD (89.7%), and the diagnosis of SCD was performed in the context of complications in 92.3% of patients. The median frequency of vaso-occlusive crisis in the past 12 months was 2 (0-10). Using a validated clinical severity score based on clinical and laboratory data, no significant difference could be observed when compared to other populations.

Conclusion:
Our results represent the first comprehensive characterization of epidemiological, laboratorial, and clinical data of SCD in the region of the Brazilian Amazon. Despite the higher contribution of Amerindian ancestry previously demonstrated in this region, the main clinical characteristics of SCD seem similar to those reported in other populations.
Collaborating Beyond Collections: Engaging Tribes in Museum Exhibits
Authors: Goff Sheila , Chapoose Betsy , Cook Elizabeth , Voirol Shannon 
Published: May 2019

AbstractThere has been—and continues to be—tension between Native peoples and museums in the United States due to past collecting practices and exhibitions that strive to interpret their culture and history without their involvement. Previously, many of these exhibitions stereotyped and lumped Native peoples together, depicting their cultures as static and interpreting them and their material culture from a Western scientific perspective. Changes are being made. Collaboration between Native peoples and museums in all areas of museum work, including exhibitions, is beginning to be considered by many as a best practice. Exhibitions developed in collaboration with Native peoples, with shared curatorial authority, decidedly help ease the historic tension between the two, and they are much more vibrant and accurate than when collaboration is lacking. This article will provide three examples of collaboration, defined with our tribal partners, to develop exhibitions at History Colorado, the state history museum, concluding with lessons learned.
Narrowband signals recorded near a moulin that are not moulin tremor: a cautionary short note
Authors: Carmichael Joshua D 
Published: May 2019

AbstractGeophysicists that deploy seismic sensors in ablation zones of glaciers and ice sheets to record glaciogenic signatures can confront recording challenges caused by instrument melt-out or tilt. These challenges often require installing sensors in boreholes to delay melt-out, or securing sensors to structures that improve coupling. We show that some of these structures that were buried near a moulin at a snow-free site in the ablation zone of the Western Greenland Ice Sheet resonated as they became exposed, and caused their geophones to record temporally evolving, narrowband signals that mimic features of glaciogenic sources like moulin tremor. We quantify these artifacts with a mechanical model that shows instruments undergo structural resonance as they melt-out, at exposure rates that we predict from an ablation model (RACMO). These models reproduce general spectral features in our data, and enable us to estimate what instrument exposure reduces ice-to-sensor coupling enough to prevent icequake detection. Last, we use our resonance data to quantitatively measure how narrowband signals that originate from either artificial or glaciogenic sources will reduce the ability of certain waveform detectors (correlators) to capture transient seismic events, even if sensors remain coupled.
A MARKED COX MODEL FOR THE NUMBER OF IBNR CLAIMS: ESTIMATION AND APPLICATION
Authors: Badescu Andrei L. , Chen Tianle , Lin X. Sheldon , Tang Dameng 
Published: May 2019

AbstractIncurred but not reported (IBNR) loss reserving is of great importance for Property &amp; Casualty (P&amp;C) insurers. However, the temporal dependence exhibited in the claim arrival process is not reflected in many current loss reserving models, which might affect the accuracy of the IBNR reserve predictions. To overcome this shortcoming, we proposed a marked Cox process and showed its many desirable properties in Badescu et al. (2016).In this paper, we consider the model estimation and applications. We first present an expectation–maximization (EM) algorithm which guarantees the efficiency of the estimators unlike the moment estimation methods widely used in estimating Cox processes. In addition, the proposed fitting algorithm can be implemented at a reasonable computational cost. We examine the performance of the proposed algorithm through simulation studies. The applicability of the proposed model is tested by fitting it to a real insurance claim data set. Through out-of-sample tests, we find that the proposed model can provide realistic predictive distributions.