bluuebunny/crossref_metadata_2025_split huggingface dataset:
Associations of language barriers with very preterm children’s behavioural and socio-emotional problems across Europe
Authors: Jaekel Julia , Aubert Adrien M. , Jaekel Nils , Costa Raquel , Johnson Samantha , Zeitlin Jennifer ,   the SHIPS Research group, Lebeer J. , Van Reempts P. , Bruneel E. , Cloet E. , Oostra A. , Ortibus E. , Sarrechia I. , Boerch K. , Pedersen P. , Toome L. , Varendi H. , Männamaa M. , Ancel P. Y. , Burguet A. , Jarreau P. H. , Pierrat V. , Truffert P. , Maier R. F. , Zemlin M. , Misselwitz B. , Wohlers L. , Cuttini M. , Croci I. , Carnielli V. , Ancora G. , Faldella G. , Ferrari F. , Koopman-Esseboom C. , Gadzinowski J. , Mazela J. , Montgomery A. , Pikuła T. , Barros H. , Costa R. , Rodrigues C. , Aden U. , Draper E. S. , Fenton A. , Johnson S. J. , Mader S. , Thiele N. , Pfeil J. M. , Petrou S. , Kim S. W. , Andronis L. , Zeitlin J. , Aubert A. M. , Bonnet C. , El Rafei R. , Seppänen A. V. 
Published: November 2024

Abstract
Background
Very preterm birth (<32 weeks gestation, VP), immigrant background, and language barriers are all independently associated with a high risk for mental health problems in childhood, but research has neglected the long-term development of immigrant children born VP. We assessed whether behavioural and socio-emotional problems of 5-year-old children born VP growing up across different language contexts in the European Union are associated with an immigrant background and linguistic distance of families’ mother tongue (L1) to the host countries’ official languages.

Methods
Data are from a population-based cohort including all VP births in 2011/12 in 11 European countries; a total of 3,067 children were followed up at 2 and 5 years of age. Behavioural and socio-emotional difficulties were assessed using the parent-reported Strengths and Difficulties Questionnaire (SDQ).

Results
Mixed-effects models showed that a larger linguistic distance of children’s L1 to the host countries’ official language was associated with higher SDQ total scores (0.02 [0.01, 0.03]), after adjusting for a wide range of social risks, biological, and perinatal clinical factors.

Conclusion
Language barriers in the form of linguistic distance between VP children’s L1 and countries’ official languages play a critically important role for the behavioural and socio-emotional development of immigrant children born VP.

Impact

Immigrant children born very preterm across Europe face systemic inequalities such as language barriers. Language barriers can be operationalised as a continuous linguistic distance score between children’s mother tongues and countries’ official languages. Linguistic distance plays an important role for the behavioural and socio-emotional development of immigrant children born VP. Research, policy, and practice need to better account for language barriers to increase equity in health and education.
Comparative evaluation of sealing ability and adaptation of gel form of MTA to dentinal walls: an in-vitro study
Authors: Parthasarathy Haritha , Modak Akshara , Yarmunja Mahabala Karuna , Natarajan Srikant , Baliga Shrikala , Thomas Manuel , Rao Ashwin , Nayak Anupama 
Published: November 2024

Abstract
Context
Mineral Trioxide Aggregate (MTA) is a calcium silicate-based cement that potentially exhibits improved washout resistance when carboxymethyl chitosan or gelatin is incorporated. Gel-form MTA is a novel mineral trioxide aggregate formulated using construction industry-based technology. The present study was conducted to comparatively evaluate the sealing ability and adaptation to dentinal walls of gel-form MTA.

Materials and methods
This in-vitro study consisted of two groups: gel-form MTA and the conventional powder-liquid MTA. 10 samples per group were used for each of the tested parameters. Adaptation of the MTA to the dentinal walls was tested under the light microscope and measured using Image J software. Sealing ability was evaluated using a single aerobic bacterial leakage model. Appropriate statistical analysis was done for the obtained data. Adaptation of the MTA was analyzed using independent t-test and Friedman test, whereas the bacterial leakage was analyzed using chi-square test.

Results
On comparison of the adaptation property at coronal and apical thirds, there was no statistically significant difference between the groups (p = 0.071 and p = 0.638, respectively). However, while comparing the same in the middle one-third of the root, lesser gaps were identified in the gel-form MTA group (p = 0.013). One sample belonging to the conventional powder-liquid MTA group showed significant turbidity during bacteria leakage evaluation (p = 0.001) with the presence of E. faecalis in the count of 103 colony forming units/milliliter.

Conclusion
The gel-form MTA shows a better adaptation to the dentinal walls at the middle third of the root and exhibits better sealing ability against bacterial leakage when tested for E. faecalis. The adaptation of gel-form MTA at coronal and apical third of the root was comparable to the conventional powder-liquid MTA.
Enhancing mitochondrial one-carbon metabolism is neuroprotective in Alzheimer’s disease models
Authors: Yu Yizhou , Chen Civia Z. , Celardo Ivana , Tan Bryan Wei Zhi , Hurcomb James D. , Leal Nuno Santos , Popovic Rebeka , Loh Samantha H. Y. , Martins L. Miguel 
Published: November 2024

AbstractAlzheimer’s disease (AD) is the most common form of age-related dementia. In AD, the death of neurons in the central nervous system is associated with the accumulation of toxic amyloid β peptide (Aβ) and mitochondrial dysfunction. Mitochondria are signal transducers of metabolic and biochemical information, and their impairment can compromise cellular function. Mitochondria compartmentalise several pathways, including folate-dependent one-carbon (1C) metabolism and electron transport by respiratory complexes. Mitochondrial 1C metabolism is linked to electron transport through complex I of the respiratory chain. Here, we analysed the proteomic changes in a fly model of AD by overexpressing a toxic form of Aβ (Aβ-Arc). We found that expressing Aβ-Arc caused alterations in components of both complex I and mitochondrial 1C metabolism. Genetically enhancing mitochondrial 1C metabolism through Nmdmc improved mitochondrial function and was neuroprotective in fly models of AD. We also found that exogenous supplementation with the 1C donor folinic acid improved mitochondrial health in both mammalian cells and fly models of AD. We found that genetic variations in MTHFD2L, the human orthologue of Nmdmc, were linked to AD risk. Additionally, Mendelian randomisation showed that increased folate intake decreased the risk of developing AD. Overall, our data suggest enhancement of folate-dependent 1C metabolism as a viable strategy to delay the progression and attenuate the severity of AD.
Exploring the potential of dental calculus to shed light on past human migrations in Oceania
Authors: Velsko Irina M. , Fagernäs Zandra , Tromp Monica , Bedford Stuart , Buckley Hallie R. , Clark Geoffrey , Dudgeon John , Flexner James , Galipaud Jean-Christophe , Kinaston Rebecca , Lewis Cecil M. , Matisoo-Smith Elizabeth , Nägele Kathrin , Ozga Andrew T. , Posth Cosimo , Rohrlach Adam B. , Shing Richard , Simanjuntak Truman , Spriggs Matthew , Tamarii Anatauarii , Valentin Frédérique , Willie Edson , Warinner Christina 
Published: November 2024

AbstractThe Pacific islands and Island Southeast Asia have experienced multiple waves of human migrations, providing a case study for exploring the potential of ancient microbiomes to study human migration. We perform a metagenomic study of archaeological dental calculus from 102 individuals, originating from 10 Pacific islands and 1 island in Island Southeast Asia spanning ~3000 years. Oral microbiome DNA preservation in calculus is far higher than that of human DNA in archaeological bone, and comparable to that of calculus from temperate regions. Oral microbial community composition is minimally driven by time period and geography in Pacific and Island Southeast Asia calculus, but is found to be distinctive compared to calculus from Europe, Africa, and Asia. Phylogenies of individual bacterial species in Pacific and Island Southeast Asia calculus reflect geography. Archaeological dental calculus shows good preservation in tropical regions and the potential to yield information about past human migrations, complementing studies of the human genome.
Structural insight into the distinct regulatory mechanism of the HEPN–MNT toxin-antitoxin system in Legionella pneumophila
Authors: Jin Chenglong , Jeon Cha-Hee , Kim Heung Wan , Kang Jin Mo , Choi Yuri , Kang Sung-Min , Lee Hyung Ho , Kim Do-Hee , Han Byung Woo , Lee Bong-Jin 
Published: November 2024

AbstractHEPN–MNT, a type VII TA module, comprises the HEPN toxin and the MNT antitoxin, which acts as a nucleotidyltransferase that transfers the NMP moiety to the corresponding HEPN toxin, thereby interfering with its toxicity. Here, we report crystal structures of the Legionella pneumophila HEPN–MNT module, including HEPN, AMPylated HEPN, MNT, and the HEPN–MNT complex. Our structural analysis and biochemical assays, suggest that HEPN is a metal-dependent RNase and identify its active site residues. We also elucidate the oligomeric state of HEPN in solution. Interestingly, L. pneumophila MNT, which lacks a long C-terminal α4 helix, controls the toxicity of HEPN toxin via a distinct binding mode with HEPN. Finally, we propose a comprehensive regulatory mechanism of the L. pneumophila HEPN–MNT module based on structural and functional studies. These results provide insight into the type VII HEPN–MNT TA system.
Zfp260 choreographs the early stage osteo-lineage commitment of skeletal stem cells
Authors: Weng Yuteng , Feng Yanhuizhi , Li Zeyuan , Xu Shuyu , Wu Di , Huang Jie , Wang Haicheng , Wang Zuolin 
Published: November 2024

AbstractThe initial fine-tuning processes are crucial for successful bone regeneration, as they guide skeletal stem cells through progenitor differentiation toward osteo- or chondrogenic fate. While fate determination processes are well-documented, the mechanisms preceding progenitor commitment remain poorly understood. Here, we identified a transcription factor, Zfp260, as pivotal for stem cell maturation into progenitors and directing osteogenic differentiation. Zfp260 is markedly up-regulated as cells transition from stem to progenitor stages; its dysfunction causes lineage arrest at the progenitor stage, impairing bone repair. Zfp260 is required for maintaining chromatin accessibility and regulates Runx2 expression by forming super-enhancer complexes. Furthermore, the PKCα kinase phosphorylates Zfp260 at residues Y173, S182, and S197, which are essential for its functional activity. Mutations at these residues significantly impair its functionality. These findings position Zfp260 as a vital factor bridging stem cell activation with progenitor cell fate determination, unveiling a element fundamental to successful bone regeneration.
Preconfigured cortico-thalamic neural dynamics constrain movement-associated thalamic activity
Authors: González-Pereyra Perla , Sánchez-Lobato Oswaldo , Martínez-Montalvo Mario G. , Ortega-Romero Diana I. , Pérez-Díaz Claudia I. , Merchant Hugo , Tellez Luis A. , Rueda-Orozco Pavel E. 
Published: November 2024

AbstractNeural preconfigured activity patterns (nPAPs), conceptualized as organized activity parcellated into groups of neurons, have been proposed as building blocks for cognitive and sensory processing. However, their existence and function in motor networks have been scarcely studied. Here, we explore the possibility that nPAPs are present in the motor thalamus (VL/VM) and their potential contribution to motor-related activity. To this end, we developed a preparation where VL/VM multiunitary activity could be robustly recorded in mouse behavior evoked by primary motor cortex (M1) optogenetic stimulation and forelimb movements. VL/VM-evoked activity was organized as rigid stereotypical activity patterns at the single and population levels. These activity patterns were unable to dynamically adapt to different temporal architectures of M1 stimulation. Moreover, they were experience-independent, present in virtually all animals, and pairs of neurons with high correlations during M1-stimulation also presented higher correlations during spontaneous activity, confirming their preconfigured nature. Finally, subpopulations expressing specific M1-evoked patterns also displayed specific movement-related patterns. Our data demonstrate that the behaviorally related identity of specific neural subpopulations is tightly linked to nPAPs.
Stabilising CO2 concentration as a channel for global disaster risk mitigation
Authors: Lu Saite , Tambakis Demosthenes 
Published: November 2024

AbstractWe investigate the influence of anthropogenic $$\hbox {CO}_2$$

CO
2

concentration fluctuations on the likelihood of climate-related disasters. We calibrate annual incidence rates against global disasters and $$\hbox {CO}_2$$

CO
2

growth spanning from 1960 to 2022 based on a dynamic panel logit model. We also study the sensitivity of disaster incidence to stochastic carbon dynamics consistent with IPCC-projected climate outcomes for 2100. The key insight is that present and lagged $$\hbox {CO}_2$$

CO
2

growth contains valuable information about the likelihood of future disaster events. We further show that lowering carbon stock uncertainty by dampening the persistence or the variability of $$\hbox {CO}_2$$

CO
2

concentration has a first-order impact on mitigating expected disaster risk.
Deep Kronecker LeNet for human motion classification with feature extraction
Authors: Pardhu Thottempudi , Kumar Vijay , Durbhakula Kalyan C. 
Published: November 2024

AbstractHuman motion classification is gaining more interest among researchers, and it is significant in various applications. Human motion classification and assessment play a significant role in health science and security. Technology-based human motion evaluation deploys motion sensors and infrared cameras for capturing essential portions of human motion and key facial elements. Nevertheless, the prime concern is providing effectual monitoring sensors amidst several stages with less privacy. To overcome this issue, we have developed a human motion categorization system called Deep Kronecker LeNet (DKLeNet), which uses a hybrid network.The system design of impulse radio Ultra-Wide Band (IR-UWB) through-wall radar (TWR) is devised, and the UWB radar acquires the signal. The acquired signal is passed through the gridding phase, and then the feature extraction unit is executed. A new module DKLeNet, which is tuned by Spotted Grey Wolf Optimizer (SGWO), wherein the layers of these networks are modified by applying the Fuzzy concept. In this model, the enhanced technique DKLeNet is unified by Deep Kronecker Network (DKN) and LeNet as well as the optimization modules SGWO is devised by Spotted Hyena Optimizer (SHO) and Grey Wolf Optimizer (GWO). The classified output of human motion is based on human walking, standing still, and empty. The analytic measures of DKLeNet_SGWO are Accuracy, True positive rate (TPR), True Negative rate (TNR), and Mean squared error (MSE) observed as 95.8%, 95.0%, 95.2%, and 38.5%, as well as the computational time observed less value in both training and testing data when compared to other modules with 4.099 min and 3.012 s.
Manner implicatures in large language models
Authors: Cong Yan 
Published: November 2024

AbstractIn human speakers’ daily conversations, what we do not say matters. We not only compute the literal semantics but also go beyond and draw inferences from what we could have said but chose not to. How well is this pragmatic reasoning process represented in pre-trained large language models (LLM)? In this study, we attempt to address this question through the lens of manner implicature, a pragmatic inference triggered by a violation of the Grice manner maxim. Manner implicature is a central member of the class of context-sensitive phenomena. The current work investigates to what extent pre-trained LLMs are able to identify and tease apart different shades of meaning in manner implicature. We constructed three metrics to explain LLMs’ behavior, including LLMs-surprisals, embedding vectors’ similarities, and natural language prompting. Results showed no striking evidence that LLMs have explainable representations of meaning. First, the LLMs-surprisal findings suggest that some LLMs showed above chance accuracy in capturing different dimensions of meaning, and they were able to differentiate neutral relations from entailment or implications, but they did not show consistent and robust sensitivities to more nuanced comparisons, such as entailment versus implications and equivalence versus entailment. Second, the similarity findings suggest that the perceived advantage of contextual over static embeddings was minimal, and contextual LLMs did not notably outperform static GloVe embeddings. LLMs and GloVe showed no significant difference, though distinctions between entailment and implication were slightly more observable in LLMs. Third, the prompting findings suggest no further supportive evidence indicating LLM’s competence in fully representing different shades of meaning. Overall, our study suggests that current dominant pre-training paradigms do not seem to lead to significant competence in manner implicature within our models. Our investigation sheds light on the design of datasets and benchmark metrics driven by formal and distributional linguistic theories.
Photoregulatory functions drive variation in eye coloration across macaque species
Authors: Perea-García Juan Olvido , Massen Jorg J. M. , Ostner Julia , Schülke Oliver , Castellano-Navarro Alba , Gazagne Eva , José-Domínguez Juan Manuel , Beltrán-Francés Víctor , Kaburu Stefano , Ruppert Nadine , Micheletta Jérôme , Gupta Shreejata , Majolo Bonaventura , Maréchal Laëtitia , Pflüger Lena S. , Böhm Pia M. , Bourjade Marie , Duran Elif , Hobaiter Catherine , Monteiro Antónia 
Published: November 2024

AbstractPrimates, the most colorful mammalian radiation, have previously served as an interesting model to test the functions and evolutionary drivers of variation in eye color. We assess the contribution of photo-regulatory and communicative functions to the external eye appearance of nine macaque species representing all the branches of their radiation. Macaques’ well described social structure and wide geographical distribution make them interesting to explore. We find that (1) the posterior option of the anterior eyeball is more pigmented closer to the equator, suggesting photoprotective functions. We also find that (2) the temporal side of the eyeball is more heavily pigmented than the nasal side. This suggests that eyeball pigmentation in macaques is distributed to reduce damage to the corneal limbus. The inclusion of a translocated population of M. fuscata in our analyses also suggests that external eye appearance may change quickly, perhaps owing to phenotypic plasticity. We find no evidence that communicative functions drive variation in external eye appearance in macaques. These results suggest that the amount of light in a species’ environment drives variation in eye coloration across macaque species. Furthermore, the geographical distribution of macaques hints at important factors that have yet to be accounted for, such as the reflectivity of the terrain a given species inhabits.
A convergent mixed methods to study registration on kidney transplantation waiting list refusal by women and men on dialysis in France
Authors: ADOLI Latame Komla , CAMPEON Arnaud , CHATELET Valérie , COUCHOUD Cécile , LOBBEDEZ Thierry , BAYER Florian , VABRET Elsa , DAUGAS Eric , VIGNEAU Cécile , JAIS Jean-Philippe , BAYAT-MAKOEI Sahar 
Published: November 2024

AbstractNot all patients on dialysis want to be registered on the kidney transplantation (KT) waiting list and undergo transplantation. The aim of this convergent mixed methods study was to determine the features of patients refusing to be registered on the KT waiting list and the reasons. Quantitative data on all 2017–2019 incident 18–85-year-old dialysis patients, eligible for KT, were extracted from the REIN registry in France. Qualitative data were collected through semi-structured interviews with patients on dialysis and nephrologists from the Bretagne, Île-de-France and Normandie French regions. The binary logistic regression method was used to identify factors/reasons associated with registration refusal and an inductive thematic analysis was performed on qualitative data. The quantitative analysis included data of 10,512 patients (mean age = 57.5 years). Among them, 860 (8.18%) refused to be registered on the KT waiting list. The multivariate analysis showed that women were 83% more likely to refuse registration compared with men. The qualitative analysis included 21 patients and 11 nephrologists. The integration of the results from the quantitative and qualitative analyses allowed identifying some factors associated with the registration refusal. Most of these factors converged across analyses. These included age, sex/gender, autonomy on dialysis and comorbidities. The integration of the results highlighted some divergence concerning sex/gender and autonomy and an area of expansion related to comorbidities. In conclusion, the patient age, sex/gender and comorbidities appear to play an important role in the refusal to be registered on the waiting list. Interventions focused on these factors might help to improve KT accessibility in France.
Improvement of EME accuracy based on an equivalent voltage acquisition method and corresponding voltage compensation strategy
Authors: Wang Mingyu , Yang Beining , Qin Yaru , Dong Guanglin 
Published: November 2024

AbstractIt is a known cost‐effective method to employ a DSP‐based electric machine emulator (EME) for motor control unit testing, this paper introduces a novel approach to enhance the emulator's accuracy. The inaccuracies caused by terminal voltage sampling errors in the motor control unit and voltage distortions in the inverter are addressed in this paper. An advanced equivalent voltage acquisition technique, which samples the duty cycle‐amplitude of the inverter's terminal voltage, is developed. Leveraging the acquired equivalent voltage data, a novel voltage compensation strategy that providing more accuracy in EME performance is proposed. The mathematical foundation of the EME is established using Kirchhoff's voltage and current laws. These findings are independently validated through simulations and experiments. The results provide robust evidence that the proposed equivalent voltage acquisition and compensation strategies can enhance the accuracy of the EME.
Retraction Note: Public investment disbursement in construction of transport infrastructure: Situation and solution
Authors: Nguyen Thi Tuyet Dung , Hoang Thi Hang Nga 
Published: November 2024

This paper has been formally retracted from publication by the authors due to a conflict of interest that was discovered post-publication. The authors are responsible for this mistake and apologise for it.
Request approved by the proceedings Editors and the Publisher on August 6, 2024.