bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaporative characteristics of sessile nanofluid droplet on micro‐structured heated surface
Authors: Zhu Gui‐Ping , Ong Kian‐Soo , Chong Karen Siew‐Ling , Yao Jia‐Feng , Huang Hu‐Lin , Duan Fei 
Published: October 2018

AbstractMicro‐structure patterned substrates attract our attention due to the special and programmable wettabilities. The interaction between the liquid and micro/nano structures gives rise to controllable spreading and thus evaporation. For exploration of the application versatility, the introduction of nanoparticles in liquid droplet results in interaction among particles, liquid and microstructures. In addition, temperature of the substrates strongly affects the spreading of the contact line and the evaporative property. The evaporation of sessile droplets of nanofluids on a micro‐grooved solid surface is investigated in terms of liquid and surface properties. The patterned nickel surface used in the experiments is designed and fabricated with circular and rectangular shaped pillars whose size ratios between interval and pillars is fixed at 5. The behavior is firstly compared between nanofluid and pure liquid on substrates at room temperature. For pure water droplet, the drying time is relatively longer due to the receding of contact line which slows down the liquid evaporation. Higher concentrations of nanoparticles tend to increase the total evaporation time. With varying concentrations of graphite at nano scale from 0.02% to 0.18% with an interval at 0.04% in water droplets and the heating temperature from 22 to 85°C, the wetting and evaporation of the sessile droplets are systematically studied with discussion on the impact parameters and the resulted liquid dynamics as well as the stain. The interaction among the phases together with the heating strongly affects the internal circulation inside the droplet, the evaporative rate and the pattern of particles deposition.
Proposal of design rules for ductile X‐CBFS in the framework of EUROCODE 8
Authors: Costanzo Silvia , D'Aniello Mario , Landolfo Raffaele 
Published: October 2018

SummaryCross concentrically braced frames (X‐CBFs) are commonly used as primary seismic resisting system, owing to their large lateral stiffness, simplicity of design, and relatively low constructional cost. Current EN 1998‐1 provides design rules theoretically aiming at developing ductile global plastic mechanism, namely enforcing plastic deformations in the diagonal members, while the remaining structural members and connections should elastically behave. However, as widely demonstrated by many existing studies, the design and the corresponding seismic performance of EC8‐compliant X‐CBFs are generally affected by several criticisms, eg, difficulties in sizing of diagonal members, massive and non‐economical structures, and poor seismic behavior. In light of these considerations, the research activity presented in this paper is addressed to revise the design rules and requirements given EN 1998‐1 for X‐CBFs to simplify the design process and to improve the ductility and the dissipative capacity of this structural system. Hence, design rules are proposed for the next version of EN 1998‐1 and numerically validated by means of nonlinear dynamic analyses.
Severity of somatic symptoms in outpatients with anorexia and bulimia nervosa
Authors: Weigel Angelika , Löwe Bernd , Kohlmann Sebastian 
Published: October 2018

AbstractObjectivePrior studies investigated objective somatic consequences of eating disorders whereas research on subjective somatic symptom severity, that is, profiles of subjective burden of somatic symptoms in patients with anorexia (AN) and bulimia nervosa (BN), is sparse.MethodsSomatic symptom severity (Patient Health Questionnaire‐15) was investigated in a cross‐sectional consecutive sample of outpatients with AN or BN. Using regression and mediation analyses, effects of somatic symptom severity on days of sick leave during the last 2 weeks and quality of life were examined.ResultsCompared with AN‐outpatients (n = 90, MBMI = 17.2, Mage = 27.9 years, 95% female), BN‐outpatients (n = 63, MBMI = 21.8, Mage = 29.0 years, 93% female) reported a significantly higher somatic symptom severity (p = 0.016). Increased somatic symptom severity predicted days of sick leave during the last 2 weeks (p = 0.036) and physical quality of life (p = <0.001). However, after controlling for depression and anxiety as mediators, somatic symptom severity did no longer predict psychological quality of life (p = n.s.).ConclusionsSomatic symptom severity is high in both eating disorders. As it is associated with increased sick leave during the last 2 weeks and decreased quality of life, it adds to the psychological burden of AN and BN. Future research should investigate predictors of subjective somatic symptom severity and whether direct somatic symptom management enhances treatment of AN and BN.
Food addiction in Russian adolescents: Associations with age, sex, weight, and depression
Authors: Borisenkov Mikhail F. , Tserne Tatyana A. , Bakutova Larisa A. 
Published: October 2018

AbstractObjectiveEating disorders are a cause of the recent obesity epidemic. Food addiction (FA) and factors associated with eating disorders have not been adequately studied in adolescents.MethodThe final study sample included 1,144 students. Study participants were asked to indicate their age, sex, and month of birth and fill out the Yale Food Addiction Scale for Children and Zung Self‐Rating Depression Scale.ResultsOf the total number of adolescents studied, 4.5% had FA. It was found that an increased rate of FA diagnosis existed in adolescents with moderate‐to‐severe depression (P < 0.000), overweight and obese individuals (P < 0.002), girls (P < 0.038), and the 17‐ to 18‐year‐old age group (P < 0.007).ConclusionThe data indicate that FA is positively associated with depression, obesity, age, and sex.
Geochronology and geochemistry of early Palaeozoic intrusive rocks in the Lajishan area of the eastern south Qilian Belt, Tibetan Plateau: Implications for the tectonic evolution of South Qilian
Authors: Cui Jiawei , Tian Liming , Sun Junyi , Yang Chao 
Published: October 2018

The Lajishan area, located in the South Qilian orogenic Belt, north‐eastern Tibetan Plateau, contains a compositionally diverse range of Cambrian to early Ordovician felsic intrusions that reflect the early Palaeozoic tectonic evolution of the Central Qilian Belt. This paper presents new geochemical, Sr─Nd and Lu─Hf isotopic, and zircon U─Pb data for the Tadong, Huangcaoshan, and Yindonggou plutons in the eastern Lajishan area. LA‐ICPMS U─Pb ages of 517.4 ± 1 Ma for the Tadong pluton which is the first find Late Cambrian granitoids in this area, 467 ± 1 Ma for the Huangcaoshan pluton and 446 ± 1 Ma for the Yindonggou pluton. The new data indicate that the Tadong pluton and Huangcaoshan pluton belong to I‐type granite. Their A/CNK values range from 0.82 to 1.03, suggesting a close relationship with I‐type granitoids. Their trace‐element geochemical characteristics include enrichments in the LILEs, pronounced depletions in Nb and Ta, enrichment of the LREEs relative to the HREEs, and Eu anomalies. These features are similar to those of I‐type volcanic‐arc magmas. Combined with Hf and Sr─Nd isotopic data, The Tadong pluton generated by the mixing of melts was derived from the partial melting of the Precambrian basement and mantle‐derived magmas. The Huangcaoshan pluton was derived from juvenile crust with contamination. The Yindonggou pluton shows A‐type characteristics, their A/NCK is 0.88–1.07, and 10000 × Ga/Al is higher than 2.6. They were characteristic with high Sr, low Y, low Yb, and enriched LREE. Combined with Hf and Sr─Nd isotopic data, the Yindonggou pluton was generated by the partial melting of oceanic slab material and was crustally contaminated associated with slab breakoff. Combined previous research suggests that Tadong pluton and Huangcaoshan pluton formed from southern subduction of the South Qilian ocean into the Central Qilian Belt; the Yindonggou pluton formed in collisional setting.
Composition and U—Pb ages of apatite in the Amba Dongar carbonatite–alkaline complex, India
Authors: Fosu Benjamin R. , Ghosh Prosenjit , Chew David M. , Viladkar Shrinivas G. 
Published: October 2018

AbstractThe Amba Dongar carbonatite‐alkaline complex is regarded as a late phase intrusion (ca. 65 Ma) associated with Deccan volcanism. Existing age constraints on the Amba Dongar carbonatite are based on phlogopite 40Ar–39Ar plateau ages derived from carbonatite and associated alkaline rocks within the complex. We explore the utility of apatite, a common accessory mineral in Amba Dongar carbonatites, as a petrogenetic and geochronological tool to constrain further the evolution of the carbonatites. Apatite exhibits different crystal forms—from hexagonal stubby prisms to ovoid and elongate grains. Apatite occurs as cumulate and disseminated grains that are either primary, fractured, or recrystallized. SrO content is high in primary apatite (3.17 wt%) but less in recrystallized (1.90 wt%) and disseminated grains (0.47 wt%). MnO and Cl are negligible while FeO is typically low in all samples. SiO2 content is low except for a few primary grains which measure up to 1.35 wt%, correlating with high REE content. LREEs dominate the total REE budget of Amba Dongar apatite, with HREEs below EPMA detection limit in most samples. Total REE content is generally low, though some primary apatite contains up to 3.19 wt% REEs. We also report UPb apatite ages from the carbonatites analysed in situ by LA‐ICP‐MS. The data from all samples combined on a UPb Tera–Wasserburg concordia yield a lower intercept age of 65.4 ± 2.5 Ma (MSWD = 2.8, 207Pb/206Pbi = 0.8272 ± 0.0028), and the Amba Dongar carbonatites are thus interpreted to represent a phase of coeval magmatic activity with Deccan volcanism.
Sinonasal cancer in The Netherlands: Follow‐up of a population‐based study 1989‐2014 and incidence of occupation‐related adenocarcinoma
Authors: Kuijpens J. (Hans) L. P. , Louwman Marieke W. J. , Takes Robert , Slootweg Piet J. , Burdorf Alex , van Dijk Boukje A. C. 
Published: October 2018

AbstractBackgroundLong‐term trends of sinonasal cancer in The Netherlands have been investigated with particular attention on adenocarcinoma for which wood or leather dust is a well‐known risk factor.MethodsAll 4345 patients (1989‐2014) registered in the Netherlands Cancer Registry were included. Standardized 3‐year moving incidence rates per 1 000 000/person‐years, and estimated annual percentage change (EAPC) were calculated.ResultsForty‐seven percent of the patients had squamous cell carcinoma (SCC), 12% had lymphoma, and 12% had adenocarcinoma. Sixty‐one percent of the tumors were located in the nasal cavity, 22% in the maxillary, and 11% in the ethmoidal sinus. Male incidence decreased to 11.5/1 000 000 due to less SCC (EAPC −0.9%; 95% confidence interval [CI] −1.6 to 0.3) and adenocarcinoma (EAPC −4.3%; 95% CI −5.5 to 3.1). Female incidence increased to 7/1 000 000 (EAPC +2.0%; 95% CI +1.1 to +3.0) due to more SCC (EAPC +2.2%; 95% CI +1.0 to +3.5), whereas adenocarcinoma remained stable (0.6/1 000 000; EAPC +1.1%; 95% CI −6.0 to +8.7). Tumors of the nasal cavity increased in women (EAPC +3.3%; 95% CI +2.0 to 4.7).ConclusionThe decrease of male sinonasal adenocarcinoma may be the result of preventive measures combined with less workers in high‐risk occupations.
P53‐dependent induction of ferroptosis is required for artemether to alleviate carbon tetrachloride‐induced liver fibrosis and hepatic stellate cell activation
Authors: Wang Ling , Zhang Zili , Li Mengmeng , Wang Feixia , Jia Yan , Zhang Feng , Shao Jiangjuan , Chen Anping , Zheng Shizhong 
Published: October 2018

AbstractFerroptosis is recently reported as a new mode of regulated cell death. Its essential characteristics are disturbed redox homeostasis, overloaded iron, and increased lipid peroxidation. However, the role of ferroptosis in liver fibrosis remains poorly understood. In this study, we attempted to investigate the effect of artemether (ART) on ferroptosis in hepatic fibrosis and to further clarify the possible mechanisms. Our data showed that ART treatment markedly attenuated liver injury and reduced fibrotic scar formation in the mouse model of liver fibrosis. Moreover, experiments in vitro also confirmed that ART treatment significantly decreased expression of hepatic stellate cell (HSC) activation markers. Interestingly, HSCs treated by ART presented morphological features of ferroptosis. Furthermore, ART remarkably triggered ferroptosis by promoting the accumulation of iron and lipid peroxides, whereas inhibition of ferroptosis by specific inhibitor ferrostatin‐1 (Fer‐1) completely abolished ART‐induced antifibrosis effect. More importantly, our discovery determined that tumor suppressor P53 was an upstream molecule in the facilitation of ART‐induced HSC ferroptosis. Conversely, knockdown of P53 by siRNA evidently blocked ART‐induced HSC ferroptosis in turn exacerbated liver fibrosis. Overall, our findings revealed that P53‐dependent induction of ferroptosis is necessary for ART to ameliorate CCl4‐induced hepatic fibrosis and inhibit HSC activation. © 2018 IUBMB Life, 71(1):45–56, 2019
Urinary N‐Telopeptide as Predictor of Onset of Menopause‐Related Bone Loss in Pre‐ and Perimenopausal Women
Authors: Shieh Albert , Greendale Gail A , Cauley Jane A , Karvonen‐Gutierrez Carrie , Lo Joan , Karlamangla Arun S 
Published: October 2018

ABSTRACTThe menopause transition (MT) is a period of rapid bone loss and has been proposed to be a time‐limited window for early intervention to prevent permanent microarchitectural damage and reduce the risk of subsequent fracture. To intervene early, however, we first need to be able to determine whether menopause‐related bone loss is about to begin, in advance of substantial bone loss. The objective of this study was, therefore, to assess whether urinary N‐telopeptide (U‐NTX) in pre‐ or early perimenopause can predict the onset of menopause‐related bone loss. Repeated U‐NTX measurements were obtained during pre‐ and early perimenopause in 1243 participants from the Study of Women's Health Across the Nation (SWAN). We examined the ability of U‐NTX to predict the onset of significant menopause‐related bone loss (categorical outcome, yes versus no) at the lumbar spine (LS) and femoral neck (FN), defined as annualized bone mineral density (BMD) decline at a rate faster than the smallest detectable change in BMD over the 3 to 4 years from the time of U‐NTX measurement. Adjusting for age, race/ethnicity, body mass index, urine collection time, starting BMD, and study site in multivariable, modified Poisson regression, every standard deviation increment in U‐NTX, measured at baseline in early perimenopausal women, was associated with an 18% and 22% greater risk of significant bone loss at the LS (p = 0.003) and FN (p = 0.003), respectively. The area under the receiver‐operator curve for predicting LS and FN bone loss was 0.72 and 0.72, respectively. In mixed‐effects analysis of all repeated measures of early perimenopausal U‐NTX over follow‐up, U‐NTX predicted onset of bone loss at the LS (p = 0.002) but not at the FN. We conclude that U‐NTX can be used early in the MT to determine if a woman is about to experience significant LS bone loss before there has been substantial skeletal deterioration. © 2018 The Authors. JBMR Plus is published by Wiley Periodicals, Inc. on behalf of the American Society for Bone and Mineral Research.
Therapeutic plasma exchange as a novel treatment for severe intrahepatic cholestasis of pregnancy: Case series and mechanism of action
Authors: Ovadia Caroline , Lövgren‐Sandblom Anita , Edwards Lindsey A. , Langedijk Jacqueline , Geenes Victoria , Chambers Jenny , Cheng Floria , Clarke Louise , Begum Shahina , Noori Muna , Pusey Charles , Padmagirison Radhika , Agarwal Sangita , Peerless James , Cheesman Kate , Heneghan Michael , Oude Elferink Ronald , Patel Vishal C. , Marschall Hanns‐Ulrich , Williamson Catherine 
Published: October 2018

AbstractIntroductionIntrahepatic cholestasis of pregnancy is characterised by pruritus and elevated serum bile acids. The pruritus can be severe, and pharmacological options achieve inconsistent symptomatic improvement. Raised bile acids are linearly associated with adverse fetal outcomes, with existing management of limited benefit. We hypothesised that therapeutic plasma exchange removes pruritogens and lowers total bile acid concentrations, and improves symptoms and biochemical abnormalities in severe cases that have not responded to other treatments.MethodsFour women with severe pruritus and hypercholanemia were managed with therapeutic plasma exchange. Serial blood biochemistry and visual analogue scores of itch severity were obtained. Blood and waste plasma samples were collected before and after exchange; individual bile acids and sulfated progesterone metabolites were measured with HPLC‐MS, autotaxin activity and cytokine profiles with enzymatic methods. Results were analysed using segmental linear regression to describe longitudinal trends, and ratio t tests.ResultsTotal bile acids and visual analogue itch scores demonstrated trends to transiently improve following plasma exchange, with temporary symptomatic benefit reported. Individual bile acids (excluding the drug ursodeoxycholic acid), and the sulfated metabolites of progesterone reduced following exchange (P = .03 and P = .04, respectively), whilst analysis of waste plasma demonstrated removal of autotaxin and cytokines.ConclusionsTherapeutic plasma exchange can lower potentially harmful bile acids and improve itch, likely secondary to the demonstrated removal of pruritogens. However, the limited current experience and potential complications, along with minimal sustained symptomatic benefit, restrict its current use to women with the most severe disease for whom other treatment options have been exhausted.
Clinical presentation in thrombotic thrombocytopenic purpura: Real‐world data from two Mexican institutions
Authors: Bugarin‐Estrada Emmanuel , Gómez‐De León Andrés , López‐García Yadith Karina , Díaz‐Chuc Erik Alejandro , Priesca‐Marín José Manuel , Ruiz‐Argüelles Guillermo J. , Jaime‐Pérez José Carlos , Gómez‐Almaguer David 
Published: October 2018

AbstractBackgroundThrombotic thrombocytopenic purpura (TTP) is a hematologic disease that can be fatal if not treated early. We aimed to describe the clinical characteristics of Mexican patients with idiopathic TTP.Study design and methodsWe conducted a retrospective study, including all adult patients diagnosed with idiopathic TTP from 2011 to 2017 in two Mexican centers. We further compared our results with the published literature.ResultsTwenty patients were included; 70% were female, with a median age of 38.5 years at diagnosis (range 16‐63). The median time from onset of symptoms to hospital admission was 1.5 days (range 0‐16). Most patients (85%) presented with at least one systemic manifestation at admission (including fever) and 90% had neurological symptoms, most of them major (70%) including loss of consciousness, transient focal abnormalities, headache, and confusion. Only one patient (5%) had the classical pentad at the time of admission. Kidney failure was present in 25% of patients and hemorrhagic symptoms in 60%. Digestive and cardiorespiratory symptoms were less common (45% and 15%, respectively). Median platelet count and lactate dehydrogenase were 10 500/μL and 1319 IU/L, respectively. Eighty percent of patients achieved remission following treatment. Patients admitted within the first 48 hours (after the onset of symptoms) tended to have better overall survival.ConclusionClinical presentation in Mexican TTP patients is similar to that in other countries. Early admission and a high suspicion for the disease will avoid delays in the initial work‐up and initiation of therapy, further improving prognosis.
Differentiation expression of toll‐like receptor4 (TLR4) caused by the dysregulation of microRNA‐140‐5p is responsible for the development of postoperation infection
Authors: Zheng Ge , Li Zhishu , Xiang Wenna , Huang Yumao , Pan Minli 
Published: October 2018

AbstractBackgroundToll‐like receptor4 (TLR4) has proven to be an important factor that's responsible for the development of postoperation infection. MicroRNAs (miRNAs) are widely regarded as key mediators of gene expression. The objectives of our study were to identify miRNA(s) and the target genes differentially expressed in monocytes in the individuals with postoperation infection.MethodsMiRNA microarrays were performed to identify and compare miRNA expression in monocytes from those with or without postoperative infection. In‐silico analysis was used to further investigate the target miRNAs and finally, luciferase assay and real‐time polymerase chain reaction (PCR) were performed to confirm the target miRNA identified. Enzyme‐linked immunosorbent assay, real‐time PCR and Western‐blot were performed to explore the role of miR‐140 involved in postoperation infection.ResultsMiRNA microarray results showed that ten miRNAs were upregulated in the postoperation infection group, while six miRNAs were downregulated, compared with those in the postoperation group without infection. Computational analysis was further performed to reveal that four miRNAs (miR‐140, miR‐7, miR‐448, and miR‐217) targeted the 3′‐untranslated region (UTR) of TLR4 mRNA. The luciferase assay showed that only miR‐140 inhibited luciferase activity of wild‐type TLR4 3′‐UTR and the luciferase activity of the cells cotransfected with miR‐7, miR‐448 or miR‐217 and wild‐type or mutant TLR4 3′‐UTR was comparable with the control. Furthermore, only miR‐140 levels were significantly lower in the postoperation infection group, while levels of miR‐217, miR‐7, and miR‐448 showed no obvious difference between the postoperation infection and postoperation without infection groups. TLR4, tumor necrosis factor‐α (TNF‐α), and IL‐6 levels were much higher in the postoperation infection group. In comparison with the control group, TLR4, TNF‐α and Interleukin 6 (IL‐6) levels in cells were decreased following transfection with miR‐140 mimics and TLR4 small interfering RNA. However, the cells treated with lipopolysaccharides increased TLR4, TNF‐α, and IL‐6 levels.ConclusionThis study demonstrates that miR‐140 is differentially expressed in monocytes collected from patients diagnosed with postoperation infection. The downregulation of miR‐140 cause upregulation of toll‐like receptor4 (TLR4), a proinflammatory factor, and is associated with infection risk in patients received surgery.
The protective effect exerted by ascorbic acid on DNA fragmentation of human leukocytes induced by Lachesis muta muta venom
Authors: Cardoso Trento Marcus Vinícius , de Faria Eleutério Mateus William , Silva Abreu Tatiane , Andrade Machado Gustavo Henrique , Cesar Pedro Henrique Souza , Assaid Simão Anderson , Marcussi Silvana 
Published: October 2018

AbstractThe objective of this study was to evaluate the genotoxic and mutagenic effects of the toxins present in Lachesis muta muta's venom on human peripheral blood leukocytes and the protective potential of ascorbic acid on DNA fragmentation. The venom of
L. muta muta was incubated in different concentrations (1, 2.5, 5, 7.5, 10, 15, 20, 30, 40, 50, 60, and 120 µg/mL) with human blood to evaluate DNA fragmentation using the comet, agarose gel electrophoresis, and micronucleus assays. In these concentrations evaluated, the venom of
L. muta muta induced genotoxicity (comet assay and agarose gel electrophoresis) and mutagenicity (micronucleus test), but they were not cytotoxic, as they did not change the rate of cell proliferation after cytokinesis blockade with cytochalasin B. The ascorbic acid significantly inhibited the genotoxicity induced by
L. muta muta venom in the proportions evaluated (1:0.1 and 1:0.5, venom/ascorbic acid ‐ w/w). Thus, future studies are needed to elucidate the protective mechanisms of ascorbic acid on the genotoxic effects induced by toxins present in snake venoms.