bluuebunny/crossref_metadata_2025_split huggingface dataset:
First and oldest record of Seebachia bronni, type species of Seebachia (Bivalvia: Astartidae), from the late Tithonian (Jurassic) of Kutch, India, and its palaeobiogeographic and evolutionary implications
Authors: Saha Ranita , Paul Shubhabrata , Das Shiladri S , Bardhan Subhendu 
Published: November 2024

ABSTRACT
The present study reports the oldest occurrence of Seebachia bronni Krauss, 1850, the type species of the genus Seebachia, within the Astartidae from the ferruginous oolitic bands of the upper Tithonian (Jurassic) of Kutch, western India. Although Pruvostiella (Eoseebachia), previously known as Seebachia (Eoseebachia), has been reported from the same horizon of Kutch, analyses using quantitative-morphological and morphometrical characters reveal a significant difference between Pruvostiella (Eoseebachia) and Seebachia (Seebachia). Seebachia has been reported in South Africa, Tanzania and Madagascar. Thus, the occurrence of S. bronni in India sheds light on a marine connection among these regions during the late Tithonian. The range of S. aff. bronni in the Oxfordian of Madagascar to S. bronni in the Tithonian of India and Early Cretaceous of South Africa may indicate an evolutionary size increase. A specimen of S. bronni from the Valanginian was the largest in body size and is possibly a distinct species.
Changes in clinical presentation, management, and survival outcomes in patients affected by colorectal cancer following COVID-19 pandemic
Authors: Parisi Alessandro , Giampieri Riccardo , Villani Silvia , Magnarini Alice , Gelsomino Fabio , Traisci Donatella , Barbin Francesca , Salvatore Lisa , Zichi Clizia , Di Pietro Francesca Romana , Zoratto Federica , Lanese Andrea , Petrillo Angelica , Zurlo Ina Valeria , Spallanzani Andrea , D’Ostilio Nicola , Ghidini Michele , Bensi Maria , Schietroma Francesco , Rognone Chiara , Panepinto Olimpia , Paparo Jessica , Gamba Teresa , Bisonni Renato , Di Lorenzo Sara , Daniele Bruno , Mentrasti Giulia , Berardi Rossana 
Published: November 2024

Abstract

Background
As an extended analysis of the COVID-DELAY study, we aimed to assess the impact of the COVID-19 pandemic on diagnosis, staging, and survival outcomes among patients with colorectal cancer (CRC) diagnosis performed from 2019 to 2022.

Methods
All consecutive newly diagnosed CRC patients referred to 11 Italian Oncology Departments between March and December 2019, 2020, 2021, and 2022 were enrolled. Access rate, demographics, diagnostic-therapeutic temporal intervals, and first-line progression-free survival (PFS) and OS among metastatic patients were assessed.

Results
Compared to 2019 (n = 690), an initial global reduction in new CRC cases in 2020 (n = 564, –18.3%) was observed, followed by a progressive increase in new CRC diagnoses in 2021 (n = 748, + 8.4%) and 2022 (n = 756, + 9.6%); a higher rate of TNM stage IV tumors was diagnosed in 2020 (35.4%) and 2021 (31.0%) compared to 2019 (29.6%), with normalization in 2022 (26.4%) (P &lt; .001). Not clinically relevant differences between histological diagnosis and first oncological examination, cytohistological diagnosis and systemic treatment start, first oncological appointment and systemic treatment start, treatment start and first radiological assessment between 2020 and 2021-2022 years were found. After propensity score matching according to the year of diagnosis, median OS was significantly worse in 2020, 2021, and 2022 compared to 2019 (27.6 vs 24.8 vs not reached vs 38.9 months, respectively) (P &lt; .001). Concordantly, the median PFS was significantly worse with each passing year: 13.0 vs 11.1 vs 9.2 vs 7.2 months in 2019, 2020, 2021, and 2022, respectively (P = .00027).

Conclusions
A progressive normalization in the rate of new CRC diagnosis as well as TNM stages at diagnosis, in 2021 and 2022 compared to 2020 and 2019, was found. The increase in new CRC cases might have affected some diagnostic-therapeutic time intervals in 2021-2022 years compared to 2020. Significantly, compared to the pre-pandemic phase, pandemic years were independently associated with worse PFS and OS outcomes in patients affected by metastatic disease.
Systematic literature review and meta-analysis of health state utility values in metastatic castration-resistant prostate cancer
Authors: Castro Elena , Figliuzzi Rhett , Walsh Sarah , Craigie Samantha , Nazari Jonathan , Niyazov Alexander , Samjoo Imtiaz A 
Published: November 2024

Abstract
Despite being an important goal, the preservation of quality of life of patients with metastatic castration-resistant prostate cancer (mCRPC) is poorly characterized across lines of therapy. In this review, a systematic literature review and meta-analysis were conducted to synthesize EuroQoL 5-Dimension (EQ-5D) data among adult men with asymptomatic or mildly symptomatic mCRPC in both first line (1L) and second line and later (2L+) therapy. MEDLINE, Embase, and Cochrane CENTRAL were searched from inception to October 2022 using Ovid. Supplemental searches of other data sources were also conducted (PROSPERO registration: CRD42021283512). Meta-analyses were conducted to estimate pooled EQ-5D index utility values and EQ visual analog scale (VAS) scores in both 1L and 2L+. Various sensitivity analyses were also conducted. Forty-five unique publications met the inclusion criteria. In primary studies, baseline EQ-5D index utility values ranged from 0.7 to 0.9 in 1L and 0.63 to 0.7 in 2L+. Twelve trials and observational studies were feasible for inclusion in the meta-analysis. The pooled mean baseline EQ-5D index utility value was estimated as 0.79 (95% CI, 0.70–0.84) and 0.69 (95% CI, 0.67–0.71) for 1L (n = 7 studies) and 2L + (n = 4 studies), respectively. The pooled mean baseline EQ VAS score was estimated as 74.63 (95% CI, 70.97–78.29) and 65.82 (95% CI, 64.53–67.11) in 1L and 2L+, respectively. Limitations include hampered comparability between studies due to heterogeneity in study design and geographical regions. This study provides a comprehensive synthesis of EQ-5D data presently available in adults with mCRPC in both 1L and 2L + therapy.
A Mendelian randomization study finds no evidence for causal effects of C-reactive protein on chronic pain conditions
Authors: Suri Pradeep , Tsepilov Yakov A , Elgaeva Elizaveta E , Williams Frances M K , Freidin Maxim B , Stanaway Ian B 
Published: November 2024

Abstract
This two-sample Mendelian randomization study examined causal associations of C-reactive protein (CRP) with spinal pain, the extent of multisite chronic pain, and chronic widespread musculoskeletal pain. No causal associations were found between CRP and these pain conditions.
Using freedom of information requests to access novel data sources in health professions education research
Authors: Yale Sophie E , Brown Megan E L , Byrne Matthew H V 
Published: November 2024

Abstract
Educators and researchers are reliant upon access to data to drive teaching methods, curricular improvements, and progress in medical education research. However, data are not always accessible, due to resource constraints, institutional policies, and privacy concerns. Researchers have attempted to access novel data sources through surveys, semistructured interviews, and databases; however, these methodologies are limited.
To improve access to data, Freedom of Information (FOI) Acts grant researchers the ability to formally request data that any public institute holds. Researchers have been reluctant to use this tool due to negative perceptions, despite its unique benefits.
To increase awareness of this underutilized methodology, we summarize the process of FOI Act requests, its strengths and weaknesses, and the ways in which health professions education can leverage FOI requests within research. We provide examples of the use of FOI requests as a research method within adjacent fields and nascent use within the field of health professions research. In doing so, we hope to highlight how FOI requests can be a useful tool in health professions education researchers and its potential to increase access to unique data sources.
Comprehensive multi-omics approach reveals potential therapeutic targets and agents for osteoarthritis
Authors: Gao Qingxia , Yao Dawei , Yin Zuozhen , Yu Gongchang , Shi Bin , Wang Jiaying 
Published: November 2024

Abstract

Background
The mechanisms underlying osteoarthritis (OA) remain unclear, and effective treatments are lacking. This study aims to identify OA-related genes and explore their potential in drug repositioning for OA treatment.

Methods
Transcriptome-wide association studies (TWAS) were performed using genome-wide association studies summary data and expression quantitative trait loci data from the Genotype-Tissue Expression project. Differentially expressed genes between OA patients and healthy controls were identified using four datasets from the Gene Expression Omnibus database. Gene ontology and pathway enrichment analyses identified potential hub genes associated with OA. A network-based drug repositioning approach was applied to discover potential therapeutic drugs for OA.

Results
Through TWAS and mRNA expression profiling, 7 and 167 OA-related genes were identified, respectively. From these, 128 OA-related genes were selected based on common biological processes. Using the maximal clique centrality algorithm, 10 core-related genes (JUN, VEGFA, FN1, CD44, PTGS2, STAT1, MAP 2K7, GRB2, EP300, and PXN) were identified for network-based drug repositioning. Consequently, 24 drugs were identified based on 128 OA-related genes and 23 drugs based on 10 core OA-related genes. Some identified drugs, such as dexamethasone, menadione, and hyaluronic acid, have been previously reported for OA and/or rheumatoid arthritis treatment. Network analysis also indicated that spironolactone, lovastatin, and atorvastatin may have potential in OA treatment.

Conclusion
This study identified potential OA-related genes and explored their roles in drug repositioning, suggesting the repurposing of existing drugs and the development of new therapeutic options for OA patients.
Key message What is already known on this topic The exact pathogenesis of osteoarthritis (OA) remains unclear, and currently, there are no approved drugs that can prevent, halt, or inhibit the progression of OA. What this study adds We identified 128 OA-related genes and 10 core-related genes based on common biological processes revealed by TWAS and mRNA expression profiling. Using these genes, we discovered potential drugs for OA through the Network-based drug repositioning method. How this study might affect research, practice, or policy This study provides recommendations for repositioning existing drugs and developing new treatment options for patients with OA.
Protestant Elements in the Piers Plowman Texts of Robert Crowley and Takamiya MS 23
Authors: Cornelius Ian , Ensley J. Eric 
Published: November 2024

Abstract
Recent studies of Robert Crowley’s editions of Piers Plowman emphasize Crowley’s fidelity to the manuscript tradition and efforts to produce an accurate and comprehensible text. The present article supports this assessment by comparing Crowley’s editions with New Haven, Beinecke Library, MS Takamiya 23 (olim Sion College, MS Arc. L.40. 2/E), a manuscript produced about the same time as the Crowley editions and closely related to Crowley’s principal exemplar. Censorship and other doctrinal alterations are infrequent in Takamiya 23 but unambiguous. While the great majority of unique readings have no evident motive beyond linguistic modernization, the Takamiya scribe also, in a few instances, harmonized the language of the medieval poem with sixteenth-century English Bibles and made discrete interpretative changes that sometimes align with Crowley’s outlook and sometimes seemingly depart from it. Another distinguishing feature of Takamiya 23 is the scribe’s apparent lack of interest in ‘prophetic’ passages, a salient focus of recent scholarship. For a more adequate account of the sixteenth-century reception of Piers Plowman, students may need to look beyond both ‘Protestantism’ and ‘prophecy’.
Minimally Invasive Unilateral Pedicle Combined with Contralateral Translaminar Facet Joint Screw Fixation for single-segment Lumbar Degenerative Disease
Authors: An Bochen , Ren Bowen , Liu Yihao , Liu Qingzu , Liu Chongyang , Han Zhenchuan , Wu Jianhui , Mao Keya , Liu Jianheng 
Published: November 2024

Study Design.
This retrospective study compared unilateral pedicle screw combined with contralateral translaminar facet joint screw (UPS+TFS) fixation with bilateral pedicle screw (BPS) fixation in patients undergoing minimally invasive transforaminal lumbar interbody fusion (MIS-TLIF) for single-segment lumbar degenerative disease.

Objective.
To assess the long-term clinical efficacy of UPS+TFS fixation and BPS fixation in MIS-TLIF.

Summary of Background Data.
Limited research exists on the long-term clinical outcomes of UPS+TFS fixation in MIS-TLIF. This study addresses this gap by comparing UPS+TFS with the more common BPS fixation technique.

Methods.
A retrospective analysis of 151 patients with single-segment lumbar degenerative disease treated with MIS-TLIF at XXX Hospital (March 2011–December 2012) was conducted. Propensity score matching (1:1) resulted in 32 patients per group (UPS+TFS and BPS). Basic demographic characteristics, preoperative functional scores, perioperative indicators, and postoperative complications were compared between the groups. Lumbar and leg Visual Analog Scale (VAS), Oswestry Disability Index (ODI), and Japanese Orthopaedic Association (JOA) scores up to 10 years postoperatively were also compared. The surgical outcomes of both groups were evaluated using the MacNab criteria at the final follow-up.

Results.
The UPS+TFS group had significantly lower lumbar VAS scores at three months postoperatively (P<0.05) with less intraoperative blood loss, shorter surgery time, and reduced hospital stay compared to the BPS group (P<0.05). No significant differences were found in the JOA or ODI scores between the two groups at 3 months and 1, 3, 5, and 10 years post-surgery (P>0.05).

Conclusion.
UPS+TFS and BPS fixation during MIS-TLIF can achieve favorable clinical outcomes with no difference in long-term clinical efficacy. UPS+TFS demonstrates perioperative advantages such as reduced intraoperative blood loss, shorter operation time, reduced postoperative hospital stay, and less iatrogenic injury. Therefore, MIS-TLIF with UPS+TFS fixation is a reliable treatment for single-segment lumbar degenerative disease.
Thematic analysis of six Asian prehospital emergency medical systems to explore development principles
Authors: Ratnayake Amila , Bagaria Dinesh , Llaneta April B. , Pattanarattanamolee Ratrawee , Hoang Bui Hai , Suzuki Takaaki , Fukushima Kenji , Nguyen Minh , Phongphuttha Weerasak , Tiglao Patrick Joseph G. , Banerjee Niladri , de Silva Sohan , De Silva Srilal , Agarwal Harshit , Santamaria Emelia B. , Pintatham Kriangsak , Le Xuan Quy , Nakahara Shinji 
Published: November 2024

Abstract

Background
Well-designed and functioning emergency medical service (EMS) can provide equitable access to emergency care to improve health issues, especially in low- and middle-income countries where the majority of deaths are due to conditions that could be treated with emergency care. To address this gap, this study explored the contextually appropriate development process in addition to the system architecture, which is lacking in Global South EMS research.

Method
This study was a thematic analysis of the development of EMS systems in six Asian countries. Experts in emergency care were selected through convenience sampling. Each country described and evaluated its EMS system using a standardized form with 102 EMS items that cover the emergency care system in terms of leadership, governance, financing, community-based activities, prehospital care, and quality assessment. From the descriptions, various themes were extracted focusing on the developmental perspective of EMS in Asia.

Result
The study identified the domain of the developmental focus, best practices, and future strategies for EMS in the Asian region. The identified areas for developmental focus are governance, multidisciplinary collaboration, communication/coordination, community participation, decentralization, equitable access, supply-demand balance, and quality assurance activities.

Conclusion
Countries under investigation achieved progress in planning, implementing, and sustaining EMS through varied strategies in the mentioned focal areas that can be emulated by other countries in this region. Further, their development levels varied according to the extent to which each country realized the development principles identified in this study.
Policy Surveillance Methods Applied to NORM and TENORM Regulation in the Southeast United States
Authors: Lynn Spenser , Caffrey Emily , Wilson Charles 
Published: November 2024

Abstract
The regulation of naturally occurring radioactive materials (NORM) and technologically enhanced naturally occurring radioactive material (TENORM) at the state level in the United States of America varies significantly from state to state. Policy surveillance methods and associated technologies have been developed to monitor and evaluate the effectiveness of public health policies. Previous research has demonstrated that policy surveillance methods can be applied to state radiation regulations; however, no organization has taken steps to incorporate these results into a permanent database with a continuous data lifecycle program. The first goal of this project aims to apply policy surveillance methods to NORM and TENORM regulations in five southeastern states in the United States with a focus on basic definitions and general licensing requirements. The second goal is to introduce policy surveillance methods to health physicists and act as a blueprint for establishing additional datasets of radiation regulations.
Negative Pressure Wound Therapy With Instillation as an Early Intervention for Extensive Wounds From Necrotizing Fasciitis
Authors: Myers Beth A. 
Published: November 2024

BACKGROUND
Ms. S was a 50-year-old woman hospitalized with necrotizing fasciitis from a labial abscess. After several surgical interventions wound debridements were performed consecutively for 6 days. She was left with extensive full thickness tissue destruction of her abdomen, bilateral groin areas, and complete displacement of skin over her mons pubis. Wounds related to necrotizing fasciitis can be especially challenging to manage, especially when the perineal region is involved. Due to the location of such wounds, it can be difficult to maintain dressings, including negative pressure wound therapy with instillation devices (NPWTi). Ms. S. also had a history of uncontrolled diabetes mellitus, which can hinder wound healing.

CASE
The Wound, Ostomy and Continence (WOC) nurse was consulted on day 6 of Ms. S’s admission, for application of NPWTi. Complex NPWTi dressings were completed in the operating room (OR), 2 times weekly for 2 weeks. When Ms. S was transferred from the intensive care unit to the surgical unit, NPWT dressings with instillation were used but later converted to standard NPWT, changed twice weekly by the WOC nurse. Dressings were changed at the bedside until day 29 of her admission.

CONCLUSION
The management of Ms. S’s extensive wounds was successful, and her wounds were closed by plastic surgery on day 29 of her admission. Ms. S was the first patient at our hospital with extensive wounds from necrotizing fasciitis to undergo surgical closure of her wounds during the same hospital admission.
Unraveling SARS-CoV-2 Host-Response Heterogeneity through Longitudinal Molecular Subtyping
Authors: Wang Kexin , Nie Yutong , Maguire Cole , Syphurs Caitlin , Sheen Heejune , Karoly Meagan , Lapp Linda , Gygi Jeremy P. , Jayavelu Naresh Doni , Patel Ravi K. , Hoch Annmarie ,   IMPACC Network, Corry David , Kheradmand Farrah , McComsey Grace A. , Fernandez-Sesma Ana , Simon Viviana , Metcalf Jordan P. , Higuita Nelson I Agudelo , Messer William B. , Davis Mark M. , Nadeau Kari C. , Kraft Monica , Bime Chris , Schaenman Joanna , Erle David , Calfee Carolyn S. , Atkinson Mark A. , Brackenridge Scott C. , Hafler David A. , Shaw Albert , Rahman Adeeb , Hough Catherine L. , Geng Linda N. , Ozonoff Al , Haddad Elias K. , Reed Elaine F. , van Bakel Harm , Kim-Schultz Seunghee , Krammer Florian , Wilson Michael , Eckalbar Walter , Bosinger Steven , Langelier Charles R. , Sekaly Rafick P. , Montgomery Ruth R. , Maecker Holden T. , Krumholz Harlan , Melamed Esther , Steen Hanno , Pulendran Bali , Augustine Alison D. , Cairns Charles B. , Rouphael Nadine , Becker Patrice M. , Fourati Slim , Shannon Casey P. , Smolen Kinga K. , Peters Bjoern , Kleinstein Steven H. , Levy Ofer , Altman Matthew C. , Iwasaki Akiko , Diray-Arce Joann , Ehrlich Lauren I. R. , Guan Leying 
Published: November 2024

AbstractHospitalized COVID-19 patients exhibit diverse immune responses during acute infection, which are associated with a wide range of clinical outcomes. However, understanding these immune heterogeneities and their links to various clinical complications, especially long COVID, remains a challenge. In this study, we performed unsupervised subtyping of longitudinal multi-omics immunophenotyping in over 1,000 hospitalized patients, identifying two critical subtypes linked to mortality or mechanical ventilation with prolonged hospital stay and three severe subtypes associated with timely acute recovery. We confirmed that unresolved systemic inflammation and T-cell dysfunctions were hallmarks of increased severity and further distinguished patients with similar acute respiratory severity by their distinct immune profiles, which correlated with differences in demographic and clinical complications. Notably, one critical subtype (SubF) was uniquely characterized by early excessive inflammation, insufficient anticoagulation, and fatty acid dysregulation, alongside higher incidences of hematologic, cardiac, and renal complications, and an elevated risk of long COVID. Among the severe subtypes, significant differences in viral clearance and early antiviral responses were observed, with one subtype (SubC) showing strong early T-cell cytotoxicity but a poor humoral response, slower viral clearance, and greater risks of chronic organ dysfunction and long COVID. These findings provide crucial insights into the complex and context-dependent nature of COVID-19 immune responses, highlighting the importance of personalized therapeutic strategies to improve both acute and long-term outcomes.