bluuebunny/crossref_metadata_2025_split huggingface dataset:
Psychometric testing of the Caring Behaviors Inventory for nursing students
Authors: Fenizia Elisa , Marchetti Anna , Biagioli Valentina , Romano Maria C. , Raso Annalisa , Gambera Angelo , De Marinis Maria Grazia , Piredda Michela 
Published: June 2019

AbstractAim and objectiveTo test the psychometric properties of the nursing students' version of the 24‐item Caring Behaviours Inventory.BackgroundCaring is at the heart of nursing and should also be a core value in nursing education. Caring can be manifested through measurable behaviours. The Caring Behaviors Inventory is a valid and reliable measure of nurses' caring behaviours in clinical settings. It has already been used among nursing students, but it needs more psychometric testing.DesignCross‐sectional validation study.MethodThe questionnaire was filled in by 300 undergraduate nursing students at two Italian universities in May 2016. Exploratory factor analysis was conducted using Mplus maximum likelihood with GEOMIN oblique rotation. A multifaceted approach was used to evaluate the model fit. The STROBE checklist for cross‐sectional studies was followed.ResultsFour dimensions were identified: “being with,” “doing with competence,” “responding to individual needs” and “providing effective care.” Adequate fit indices and high reliability of the factors were found. Correlations between factors were positive and significant.ConclusionThis study makes it possible to use the same tool to compare the caring practices perceived by students, nurses and patients. Further studies with bigger samples could be stratified to investigate the associations between caring levels and student characteristics. The Caring Behaviors Inventory can be used to call attention to caring in nursing education, helping to make this concept less elusive.Relevance to clinical practiceThe effective self‐assessment of nursing students' caring behaviours offers opportunities for reflection on their caring practice. This could improve the caring level of their behaviours in clinical practice and help them to become caring nurses in the future.
The symptoms, resourcefulness and quality of life in community‐based patients with schizophrenia
Authors: Yu Ching‐Yun , Lai Chien Yu , Chang Yu‐Shan , Wu Ching‐Kuan , Chung Feng‐Chin 
Published: June 2019

AbstractAims and objectivesTo test Zauszniewski's resourcefulness and quality of life theory in community‐based patients with schizophrenia. The objectives were to: (a) examine the relationship among psychotic symptoms, resourcefulness and quality of life, and (b) explore the determinants of quality of life.BackgroundAccording to Zauszniewski's resourcefulness and quality of life theory, for patients, the skills constituting resourcefulness should centre on helping oneself or the use of resources to achieve their health. While the significant associations between resourcefulness and quality of life have been consistently delineated in published research, little is known about resourcefulness in patients with schizophrenia.DesignA cross‐sectional study design was used in this study.MethodsA total of 120 patients were recruited with convenience sampling who received home care service and community rehabilitation programme. The participants were assessed with the Brief Psychiatric Rating Scale, the Resourcefulness Scale and the World Health Organization Quality of Life Scale‐BREF. The psychotic symptoms were rated by the researchers with structured face‐to‐face interviews. Resourcefulness and quality of life were assessed through self‐reporting. STROBE checklist was followed.ResultsThe data were analysed using one‐way analysis of variance, t test, Pearson's correlation coefficients and stepwise multiple regression analysis. Results showed that employment status and psychotic symptoms were correlated with resourcefulness, while employment status, psychotic symptoms and resourcefulness were correlated with quality of life. Resourcefulness and psychotic symptoms were the determinants of quality of life.ConclusionPatients with employment and less psychotic symptoms had greater resourcefulness. In addition, patients with employment, less psychotic symptoms and greater resourcefulness had better quality of life.Relevance to clinical practiceCommunity rehabilitation programmes should include supported employment, symptom management and resourcefulness skills training to enhance patients' resourcefulness and quality of life.
Online information on dysmenorrhoea: An evaluation of readability, credibility, quality and usability
Authors: Lovett Jordan , Gordon Candice , Patton Shelby , Chen Chen X. 
Published: June 2019

AbstractAims and objectivesTo evaluate online information on dysmenorrhoea, including readability, credibility, quality and usability.BackgroundMenstrual pain impacts 45%–95% of women of reproductive age globally and is the leading cause of school and work absences among women. Women often seek online information on dysmenorrhoea; however, little is known about the information quality.DesignThis was a descriptive study to evaluate online information on dysmenorrhoea.MethodsWe imitated search strategies of the general public. Specifically, we employed the three most popular search engines worldwide—Google, Yahoo and Bing—and used lay search terms, “period pain” and “menstrual cramps.” We screened 60 web pages. Following removal of duplicates and irrelevant web pages, 25 met the eligibility criteria. Two team members independently evaluated the included web pages using standardised tools. Readability was evaluated with the Flesch–Kincaid Reading Ease and Flesch–Kincaid Grade formulas; credibility, quality and usability were evaluated with established tools. We followed the STROBE checklist for reporting this study.ResultsFor readability, the mean Flesch–Kincaid level was 10th grade. For credibility, 8% of web pages referenced scientific literature and 28% stated the author's name and qualifications. For quality, no web page employed user‐driven content production; 8% of web pages referenced evidence‐based guidelines, 32% of web pages had accurate content, and 4% of web pages recommended shared decision‐making. Most web pages were interactive and included nontextual information. Some nontextual information was inaccurate.ConclusionOnline information on dysmenorrhoea has generally low readability, mixed credibility and variable quality.Relevance to clinical practiceStrategies to improve health information on dysmenorrhoea include avoiding complex terms, incorporating visual aids, presenting evidence‐based information and developing a decision aid to support shared decision‐making. Healthcare providers should be aware of the problematic health information that individuals are exposed to and provide education about how to navigate online health information.
Building a predictive model for successful vaginal delivery in nulliparas with term cephalic singleton pregnancies using decision tree analysis
Authors: Zhao Rui‐Fen , Zhang Wei‐Yuan , Zhou Li , Chen Yi 
Published: June 2019

AbstractAimTo establish a model predicting successful vaginal delivery (VD) in nulliparas with term cephalic singleton pregnancies.MethodsWe retrospectively identified 6799 term nulliparas with cephalic singletons (6416 VD and 383 cesarean section [CS] due to dystocia) who entered labor (cervical dilation ≥2 cm) between September 2014 and August 2015. Using VD as the dependent variable and age, maternal body height, educational attainment, gravidity, gestational age, pre‐pregnancy body mass index (BMI), BMI upon admission for delivery, gestational weight gain, gestational hypertension and gestational diabetes as the independent variables, predictors of VD success were identified using a multivariate binary logistic regression and then ranked with decision‐tree analysis.ResultsWhile multiple factors are associated with improved VD success, we found body height, gestational age, and intrapartum BMI to be the best predictors of successful VD. Our predictive model has a classification accuracy, sensitivity and specificity of 76.6%, 96.7% and 16.4%, respectively, and it was subsequently confirmed by both internal and external validation.ConclusionOur predictive model indicates body height, gestational age and intrapartum BMI as the major predictors of successful VD in low‐risk patients.
Overexpression of AKR1B10 predicts tumor recurrence and short survival in oral squamous cell carcinoma patients
Authors: Fang Chih‐Yeu , Lin Yun‐Ho , Chen Chi‐Long 
Published: June 2019

AbstractBackgroundAldo‐keto reductase family 1 member B10 (AKR1B10) is an enzyme implicated in physiological xenobiotic detoxification and also in pathological carcinogenesis. Overexpression of AKR1B10 has been reported in oral squamous cell carcinoma (OSCC), but its correlation with clinical prognosis is controversial. The aim of this study was to investigate and clarify the role of AKR1B10 in OSCC carcinogenesis.MethodsTumor tissue specimens were surgically obtained from 107 patients with OSCC. The expression of AKR1B10 was analyzed by immunohistochemistry to explore the relationship between the level of AKR1B10 and clinicopathological features of OSCC patients. Kaplan‐Meier survival and Cox proportional hazard analysis were used to determine the prognostic value of AKR1B10 in OSCC.ResultsHigh expression of AKR1B10 was found to be associated with tumor size (P = 0.043), perineural invasion (P = 0.012), and recurrence (P = 0.001) in OSCC. Cox model analysis revealed that high expression of AKR1B10 is significantly associated with poor overall and disease‐free survival in OSCC patients. With the combination of clinicopathological factors in analysis, we found that the expression level of AKR1B10 was a practical indicator that could categorize OSCC patients into different risk groups. High expression of AKR1B10 was associated with a reduced survival in patients with well and moderately differentiated OSCC and even a high incidence of tumor recurrence in the patients with late‐stage (III and IV) disease.ConclusionWe validated and expanded data on the expression of AKR1B10 in OSCC, suggesting that it is a valuable biomarker for prognostic prediction of recurrence and survival in OSCC.
Evaluation of Educational Interventions to Enhance Adolescent Specific Vaccination Coverage
Authors: Underwood Natasha L. , Gargano Lisa M. , Sales Jessica , Vogt Tara M. , Seib Katherine , Hughes James M. 
Published: June 2019

ABSTRACTBACKGROUNDIn this study, we assessed impact of two educational interventions designed to increase coverage of three vaccines recommended during adolescence among Georgia middle and high school students (tetanus diphtheria pertussis [Tdap], meningococcal [MenACWY], and human papillomavirus [HPV] vaccines).METHODSWe randomized 11 middle and high schools in one school district into one of three arms: (1) control; (2) educational intervention for parents only (P only); and (3) multicomponent educational intervention for parents and adolescents (P + A), which consisted of educational brochures for parents about vaccines recommended during adolescence and a vaccine‐focused curriculum delivered to adolescents by science teachers. We obtained vaccination coverage data during intervention years from the state immunization registry.RESULTSOdds of receiving at least one vaccine during the study were higher among adolescents in P + A arm compared to control (Odds Ratio [OR]: 1.4; 95% Confidence Interval [CI]: 1.1–2.0). Adolescents in P + A arm had greater odds of receiving at least one vaccine compared with those in P only arm (OR: 1.4; 95% CI: 1.1–1.7).CONCLUSIONSA multicomponent educational intervention for adolescents and parents increased adolescent vaccination uptake. Results suggest similar interventions can increase awareness and demand for vaccines among parents and adolescents.
Association between nut consumption and non‐alcoholic fatty liver disease in adults
Authors: Zhang Shunming , Fu Jingzhu , Zhang Qing , Liu Li , Meng Ge , Yao Zhanxin , Wu Hongmei , Bao Xue , Gu Yeqing , Lu Min , Sun Shaomei , Wang Xing , Zhou Ming , Jia Qiyu , Song Kun , Xiang Huiling , Wu Yuntang , Niu Kaijun 
Published: June 2019

AbstractBackground & AimsIncreased nut consumption has been associated with reduced inflammation, insulin resistance, and oxidative stress. Although these factors are closely involved in the pathogenesis of non‐alcoholic fatty liver disease (NAFLD), few studies have focused on the association between nut consumption and NAFLD in the general population. We aimed to investigate the association of nut consumption and NAFLD in an adult population.MethodsA total of 23 915 participants from Tianjin Chronic Low‐Grade Systemic Inflammation and Health (TCLSIH) Cohort Study were included in this study. Information on dietary intake was collected using a validated food frequency questionnaire. Abdominal ultrasonography was done to diagnose NAFLD. Multivariable logistic regression was used to assess the association of nut consumption with NAFLD.ResultsAfter adjusting for sociodemographic, medical, dietary, and lifestyle variables, the odds ratios (95% confidence interval) for NAFLD across categories of nut consumption were 1.00 (reference) for <1 time/week, 0.91 (0.82, 1.02) for 1 time/week, 0.88 (0.76, 1.02) for 2‐3 times/week, and 0.80 (0.69, 0.92) for ≥4 times/week (P for trend < 0.01). These associations were attenuated but remained significant after further adjustment for blood lipids, glucose, and inflammation markers.ConclusionsHigher nut consumption was significantly associated with lower prevalence of NAFLD. Further prospective studies and randomized trials are required to ascertain the causal association between nut consumption and NAFLD.
DrRecQ regulates guanine quadruplex DNA structure dynamics and its impact on radioresistance in Deinococcus radiodurans
Authors: Khairnar Nivedita P. , Maurya Ganesh Kumar , Pandey Neha , Das Anubrata , Misra Hari S. 
Published: June 2019

SummaryThe GC‐rich genome of Deinococcus radiodurans contains a very high density of putative guanine quadruplex (G4) DNA motifs and its RecQ (drRecQ) was earlier characterized as a 3′→5′ dsDNA helicase. We saw that N‐Methyl mesoporphyrin IX (NMM), a G4 DNA binding drug affected normal growth as well as the gamma radiation resistance of the wild‐type bacterium. Interestingly, NMM treatment and recQ deletion showed additive effect on normal growth but there was no effect of NMM on gamma radiation resistance of recQ mutant. The recombinant drRecQ showed ~400 times higher affinity to G4 DNA (Kd = 11.74 ± 1.77 nM) as compared to dsDNA (Kd = 4.88 ± 1.30 µM). drRecQ showed ATP independent helicase function on G4 DNA, which was higher than ATP‐dependent helicase activity on dsDNA. Unlike wild‐type cells that sparingly stained for G4 structure with Thioflavin T (ThT), recQ mutant showed very high‐density of ThT fluorescence foci on DNA indicating an important role of drRecQ in regulation of G4 DNA structure dynamics in vivo. These results together suggested that drRecQ is an ATP independent G4 DNA helicase that plays an important role in the regulation of G4 DNA structure dynamics and its impact on radioresistance in D. radiodurans.
APOLLO‐2: A Randomized, Placebo and Active‐Controlled Phase III Study Investigating Oliceridine (TRV130), a G Protein–Biased Ligand at the μ‐Opioid Receptor, for Management of Moderate to Severe Acute Pain Following Abdominoplasty
Authors: Singla Neil K. , Skobieranda Franck , Soergel David G. , Salamea Monica , Burt David A. , Demitrack Mark A. , Viscusi Eugene R. 
Published: June 2019

AbstractObjectivesThe clinical utility of conventional IV opioids is limited by the occurrence of opioid‐related adverse events. Oliceridine is a novel G protein–biased μ‐opioid receptor agonist designed to provide analgesia with an improved safety and tolerability profile. This phase III, double‐blind, randomized trial (APOLLO‐2 [NCT02820324]) evaluated the efficacy and safety of oliceridine for acute pain following abdominoplasty.MethodsPatients received a loading dose of either placebo, oliceridine (1.5 mg), or morphine (4 mg), followed by demand doses via patient‐controlled analgesia (0.1, 0.35, or 0.5 mg oliceridine; 1 mg morphine; or placebo) with a 6‐minute lockout interval. The primary endpoint was the proportion of treatment responders over 24 hours for oliceridine regimens compared to placebo. Secondary outcomes included a predefined composite measure of respiratory safety burden (RSB, representing the cumulative duration of respiratory safety events) and the proportion of treatment responders vs. morphine.ResultsA total of 401 patients were treated with study medication. Effective analgesia was observed for all oliceridine regimens, with responder rates of 61.0%, 76.3%, and 70.0% for the 0.1‐, 0.35‐, and 0.5‐mg regimens, respectively, compared with 45.7% for placebo (all P < 0.05) and 78.3% for morphine. Oliceridine 0.35‐ and 0.5‐mg demand dose regimens were equi‐analgesic to morphine using a noninferiority analysis. RSB showed a dose‐dependent increase across oliceridine regimens (mean hours [standard deviation], 0.1 mg: 0.43 [1.56]; 0.35 mg: 1.48 [3.83]; 0.5 mg: 1.59 [4.26]; all comparisons not significant at P > 0.05 vs. placebo: 0.60 [2.82]). The RSB measure for morphine was 1.72 (3.86) (P < 0.05 vs. placebo). Gastrointestinal adverse events increased in a dose‐dependent manner across oliceridine demand dose regimens (0.1 mg: 49.4%; 0.35 mg: 65.8%; 0.5 mg: 78.8%; vs. placebo: 47.0%; and morphine: 79.3%). In comparison to morphine, the proportion of patients experiencing nausea or vomiting was lower with the 2 equi‐analgesic dose regimens of 0.35 and 0.5 mg oliceridine.ConclusionsOliceridine is a safe and effective IV analgesic for the relief of moderate to severe acute postoperative pain in patients undergoing abdominoplasty. Since the low‐dose regimen of 0.1 mg oliceridine was superior to placebo but not as effective as the morphine regimen, safety comparisons to morphine are relevant only to the 2 equi‐analgesic dose groups of 0.35 and 0.5 mg, which showed a favorable safety and tolerability profile regarding respiratory and gastrointestinal adverse effects compared to morphine. These findings support that oliceridine may provide a new treatment option for patients with moderate to severe acute pain where an IV opioid is warranted.
Multiple GmWRI1s are redundantly involved in seed filling and nodulation by regulating plastidic glycolysis, lipid biosynthesis and hormone signalling in soybean (Glycine max)
Authors: Chen Beibei , Zhang Gaoyang , Li Penghui , Yang Jihong , Guo Liang , Benning Christoph , Wang Xuemin , Zhao Jian 
Published: June 2019

AbstractIt has been reported that lipid biosynthesis in plant host root cells plays critical roles in legume‐fungal or ‐rhizobial symbioses, but little is known about its regulatory mechanism in legume–rhizobia interaction. Soybean WRINKLED1 (WRI1) a and b, with their alternative splicing (AS) products a’ and b’, are highly expressed in developing seeds and nodules, but their functions in soybean nodulation are not known. GmWRI1a and b differently promoted triacylglycerol (TAG) accumulation in both Arabidopsis wild‐type and wri1 mutant seeds and when they ectopically expressed in the soybean hairy roots. Transcriptome analysis revealed that 15 genes containing AW boxes in their promoters were targeted by GmWRI1s, including genes involved in glycolysis, fatty acid (FA) and TAG biosynthesis. GmWRI1a, GmWRI1b and b’ differentially transactivated most targeted genes. Overexpression of GmWRI1s affected phospholipid and galactolipid synthesis, soluble sugar and starch contents and led to increased nodule numbers, whereas GmWRI1 knockdown hairy roots interfered root glycolysis and lipid biosynthesis and resulted in fewer nodules. These phenomena in GmWRI1 mutants coincided with the altered expression of nodulation genes. Thus, GmWRI1‐regulated starch degradation, glycolysis and lipid biosynthesis were critical for nodulation. GmWRI1 mutants also altered auxin and other hormone‐related biosynthesis and hormone‐related genes, by which GmWRI1s may affect nodule development. The study expands the views for pleiotropic effects of WRI1s in regulating soybean seed filling and root nodulation.
Creating a Linked Consumer Register for Granular Demographic Analysis
Authors: Lansley Guy , Li Wen , Longley Paul A. 
Published: June 2019

Summary
A very large share of the adult population frequently assent to provide data on their place of residence to local governments and businesses when registering for or acquiring goods and services. When linked together, such data can provide highly granular inventories of local populations and their characteristics on far faster refresh cycles than conventional statistical sources. However, each of the constituent sources of data is of largely unknown provenance. We describe how careful curation, linkage and analysis of sources of consumer and administrative data can resolve many questions of content and coverage, resulting in comprehensive, highly disaggregate and frequently updateable representations of population structure, along with reliable estimates of incompleteness and possible bias. We link 20 consecutive annual public UK registers of electors to a range of sources of consumer data to create annual updates to a longitudinal profile of the adult residents of almost every domestic property. We illustrate the applicability and value of the resulting unique data resource through the derivation of an annual small area household change index. We also assess the prospects of other, related, data linkage projects.
Thirty years of theThree Worlds of Welfare Capitalism: A review of reviews
Authors: Powell Martin , Yörük Erdem , Bargu Ali 
Published: June 2019

AbstractIn the 30 or so years since the publication of Gosta Esping‐Andersenapos;sThree Worlds of Welfare Capitalisma number of rival welfare state typologies have emerged. This article has two broad aims. First, we review the reviews of welfare state typologies, pointing to issues of often unclear case selection and a wide range of concepts, variables, and methods, resulting in a variety of worlds of welfare and their constituent nations. We show that there is a great variety in the welfare modelling business at two different levels. Reviews vary significantly in terms of the number and composition of included studies, which has made it difficult to sum up the “state of the art.” Individual studies included in the reviews also vary significantly in terms of issues such as aims, concepts, variables, and methods. Second, we produce a new review, which adds value as it is based on a clearer search strategy, and includes more recent material that was not available in earlier reviews. This finds that there is a great variety in terms of process (concepts, variables, methods, and number of countries) and findings (the number and composition of “worlds”). We argue that the country classification seems to show less consensus that previous reviews, with fewer “pure” nations (i.e., agreement between studies). We suggest that in order to provide a clear point of engagement, future reviews need to pay more attention to a clear and explicit search strategy, including issues such as inclusion criteria.