bluuebunny/crossref_metadata_2025_split huggingface dataset:
SPHERE view of Wolf-Rayet 104
Authors: Soulain A. , Millour F. , Lopez B. , Matter A. , Lagadec E. , Carbillet M. , La Camera A. , Lamberts A. , Langlois M. , Milli J. , Avenhaus H. , Magnard Y. , Roux A. , Moulin T. , Carle M. , Sevin A. , Martinez P. , Abe L. , Ramos J. 
Published: July 2018

Context. WR104 is an emblematic dusty Wolf-Rayet star and the prototypical member of a sub-group hosting spirals that are mainly observable with high-angular resolution techniques. Previous aperture masking observations showed that WR104 is likely to be an interacting binary star at the end of its life. However, several aspects of the system are still unknown. This includes the opening angle of the spiral, the dust formation locus, and the link between the central binary star and a candidate companion star detected with the Hubble Space Telescope (HST) at 1′′.
Aims. Our aim was to directly image the dusty spiral or “pinwheel” structure around WR104 for the first time and determine its physical properties at large spatial scales. We also wanted to address the characteristics of the candidate companion detected by the HST.
Methods. For this purpose, we used SPHERE and VISIR at the Very Large Telescope to image the system in the near- and mid-infrared, respectively. Both instruments furnished an excellent view of the system at the highest angular resolution a single, ground-based telescope can provide. Based on these direct images, we then used analytical and radiative transfer models to determine several physical properties of the system.
Results. Employing a different technique than previously used, our new images have allowed us to confirm the presence of the dust pinwheel around the central star. We have also detected up to five revolutions of the spiral pattern of WR104 in the K band for the first time. The circumstellar dust extends up to 2 arcsec from the central binary star in the N band, corresponding to the past 20 yr of mass loss. Moreover, we found no clear evidence of a shadow of the first spiral coil onto the subsequent ones, which likely points to a dusty environment less massive than inferred in previous studies. We have also confirmed that the stellar candidate companion previously detected by the HST is gravitationally bound to WR104 and herein provide information about its nature and orbital elements.
La fluidité dans un cabinet d’orthodontie. Pourquoi, pour qui, comment ?
Authors: Race P. 
Published: July 2018

La recherche de la fluidité dans un cabinet d’orthodontie doit être un axe de réflexion impératif. La fluidité est une qualité qu’il faut viser car elle est synonyme d’efficacité et de confort et, par voie de conséquence, de rentabilité.
Cette rentabilité n’est pas exclusivement financière. Elle est aussi au niveau de l’humain. Elle permet à chaque membre de l’équipe d’apporter le meilleur de lui même dans sa fonction. Et lorsqu’une équipe est performante, les patients le ressentent. Un patient satisfait est la meilleure publicité qu’un cabinet puisse avoir. Pourquoi s’en priver ?
Démarche éco-responsable : l’orthodontie « Green »
Authors: Pourrat F. , Pourrat F. 
Published: July 2018

La démarche éco-responsable dans les cabinets dentaires et plus particulièrement orthodontiques est plutôt discrète, tout comme l’est la participation des PME.
La règlementation actuelle oblige à mettre en place des éléments allant dans le sens de la démarche éco-responsable : ERP, radiations ionisantes, déchets de soins, etc.
Aujourd’hui il nous faut aller plus loin.
Nous donnerons les éléments nécessaires à la mise en place de la démarche ainsi que des exemples d’actions à mettre en oeuvre pour participer au développement durable.
Blood meal identification in the cryptic species Anopheles gambiae and Anopheles coluzzii using MALDI-TOF MS
Authors: Tandina Fatalmoudou , Laroche Maureen , Davoust Bernard , K Doumbo Ogobara , Parola Philippe 
Published: July 2018

Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) has recently emerged in entomology as a technique to identify arthropods and their blood meal source. In this study, female Anopheles gambiae were fed on five host blood sources: ocelot (Leopardus pardalis), binturong (Arctictis binturong), springbok (Antidorcas marsupialis), jaguar (Panthera onca) and Hamadryas baboon (Papio hamadryas), while Anopheles coluzzii were fed on three hosts: dromedary (Camelus dromedarius), Barbary sheep (Ammotragus lervia) and pig (Sus scrofa). We obtained the MS spectra from 240 engorged mosquito abdomens and selected high quality ones from 72 mosquito abdomens to upgrade our home-made database. We excluded from the analysis any spectra of low quality (n = 80), and the remaining 88 specimens were subjected to a blind test analysis against the home-made database. We obtained 100% correct identification of the blood meal source for the specimens collected, 1, 12 and 24 h post-feeding, whereas for the specimens collected 36 h post-feeding, the correct identification rate decreased dramatically. We confirm here that MALDI-TOF MS can be used to identify the blood meal origin of freshly engorged mosquitoes, which opens new perspectives for further studies, including the impact of the mosquito species on blood meal identification.
Prävalenzen von Depressionen bei Erwachsenen – eine vergleichende Analyse bundesweiter Survey- und Routinedaten
Authors: Grobe Thomas G. , Kleine-Budde Katja , Bramesfeld Anke , Thom Julia , Bretschneider Julia , Hapke Ulfert 
Published: July 2018

Zusammenfassung
Ziel der Studie Prävalenzschätzungen für Depression zeigen in Primär- vs. Sekundärdaten divergente Ergebnisse. Ursachen liegen u. a. in der Betrachtung verschiedener Indikatoren zu abweichenden Zeitpunkten. In der vorliegenden Arbeit werden Depressionshäufigkeiten in Survey- und Routinedaten für einen vergleichbaren Erhebungszeitraum und Altersbereich ermittelt. Unterschiede zwischen den Datenquellen und den Depressionsmaßen werden untersucht.
Methodik Drei Indikatoren werden für das Jahr 2010 gegenübergestellt: im Bevölkerungssurvey erhobene a) selbstberichtete ärztliche Diagnosen, b) Diagnosen in standardisiertem klinischen Interview sowie c) in Routinedaten einer gesetzlichen Krankenkasse administrativ erfasste Diagnosen. In Sensitivitätsanalysen werden privat versicherte Surveyteilnehmende sowie Versicherte mit Pflegebedarf aus den Routinedaten ausgeschlossen. Die Definition der administrativen Depressionsdiagnose wird variiert je nach Kodierhäufigkeit und Diagnosespezifität.
Ergebnisse Die höchste Prävalenzrate zeigt sich mit 9,8% für administrativ erfasste Depressionen, die niedrigste mit 5,9% für die selbstberichtete Depressionsdiagnose im Survey. Die Prävalenz der im klinischen Interview erhobenen Depression beträgt 8,4%. Es zeigen sich jeweils spezifische alters- und geschlechtsabhängige Verteilungen. Bleiben unspezifische Depressionsdiagnosen (F3x.8, F3x.9) unberücksichtigt, sinkt die administrative Prävalenzrate deutlich ab.
Schlussfolgerung Je nach Definition der administrativen Depressionsdiagnose reduzieren sich Prävalenzunterschiede im Vergleich zur selbstberichteten Diagnose. Differenzen zu Prävalenzen basierend auf klinischem Interview bleiben hingegen bestehen und weisen auf die Erfassung unterschiedlicher Personengruppen hin.
Surgical Treatment of Dysphagia Lusoria Caused by Right-Aortic Arch with Kommerell Diverticulum: Left Heart Bypass without Subclavian Revascularization
Authors: Camporrotondo Mariano , Ricapito Paz , Espinoza Juan , Piccinini Fernando , Vrancic Mariano , Avegliano Gustavo , Navia Daniel 
Published: July 2018

AbstractThe authors present the case of a 26-year-old patient suffering from dysphagia because of compression by a Kommerell diverticulum in right aortic arch anomaly. Open surgical arch and descending aorta replacement with left heart bypass without left subclavian artery reimplantation was performed.
Anatomic Revascularization of the Celiac Trunk and the Superior Mesenteric Artery
Authors: Ugurlucan Murat , Aksakal Nihat , Onal Yilmaz , Oztas Didem , Alpagut Ufuk 
Published: July 2018

AbstractChronic atherosclerotic mesenteric ischemia is a debilitating disorder. It may cause postprandial abdominal pain leading to severe weight loss. Patients are usually emotionally affected with major depression. The disease can be treated with open surgical and endovascular techniques and both methods have individual risks and benefits. In this report, the authors present anatomical revascularization of the superior mesenteric artery and the celiac trunk.
Right Iliac Artery—Inferior Vena Cava Arteriovenous Fistula
Authors: Rossi Umberto , Torcia Pierluca , Rollandi Gian , Cariati Maurizio 
Published: July 2018

AbstractThis report describes a case of elderly patient with right iliac artery fissured pseudoaneurysm, leading to inferior vena cava arteriovenous fistula that was treated by covered stent device deployed at the level of the right iliac pathologic segment.
Endovascular Thoracoabdominal Replacement after Total Abdominal Aortic Debranching
Authors: Ugurlucan Murat , Onal Yilmaz , Sayin Omer , Ekiz Feza , Oztas Didem , Basaran Murat , Acunas Bulent , Alpagut Ufuk 
Published: July 2018

AbstractMarfan syndrome is an inherited connective tissue disorder affecting mainly eyes and skeletal and cardiovascular systems. Cardiovascular involvement may lead to life-threatening aortic pathologies including aneurysms and/or dissections. In this report, the authors present images of a patient with Marfan syndrome with a history of Bentall-De Bono procedure followed by aortic arch and infrarenal aortoiliac replacements who strongly refused conventional open repair and underwent abdominal debranching followed by thoracoabdominal endovascular stent grafting for the treatment of thoracoabdominal aneurysm.
Regulation of the Urokinase Receptor by Its Plasminogen Activator
Authors: Hollas W , Boyd D 
Published: July 2018

SummaryThere is now ample evidence that the proteolytic action of urokinase (UK) is potentiated by a specific cell surface receptor. The present study was undertaken to assess the role of UK as a modulator of its receptor. GEO colonic cells, which secrete relatively low levels of UK (≃0.1 nM/72 h per 106 cells) and display approximately 104 receptors per cell, 10% of which are "tagged" with the endogenous plasminogen activator (PA), was selected for the study. A 90% reduction in the specific binding of radioactive DFP-UK was observed for cells cultivated in the presence of two-chain (TC) UK (M
r 55,000). This only partly reflected occupation of the receptors with UK supplied in the culture medium, since the specific binding of the radioligand was still reduced by 60% after an acid pretreatment, which dissociates receptor-bound UK. The reduction in radioactive DFP-UK binding to cells treated with high molecular weight UK, either in the single or two-chain form, was both concentration and time dependent. Maximum reductions (70%) were achieved by treatment of the cells for 24 h with 1 nM of the plasminogen activator. In contrast, low molecular weight UK, which lacks part of the UK A chain, had no effect on ligand binding. Attenuation of radioactive DFP-UK binding to UK treated GEO cells was a consequence of a 60% reduction in the number of binding sites. Treatment of GEO cells with an antibody, which blocks the binding of endogenous UK to its receptor, augmented radioactive DFP-UK binding by two-fold. These data indicate that for one colonic cell line, at least, UK down-regulates its own binding site subsequent to it being bound to the receptor.
Improved Adhesion and Proliferation of Human Endothelial Cells on Polyethylene Precoated with Monoclonal Antibodies Directed against Cell Membrane Antigens and Extracellular Matrix Proteins
Authors: Dekker Albert , Poot André A , van Mourik Jan A , Workel Martin P A , Beugeling Tom , Bantjes Adriaan , Feijen Jan , van Aken Willem G 
Published: July 2018

SummaryEndothelial cell seeding may improve the patency of synthetic vascular grafts provided that platelet reactivity of non-endothelialized sites is not increased. We have investigated if surface-adsorbed monoclonal antibodies directed against endothelial cell membrane proteins and against extracellular matrix proteins promote the adhesion and proliferation of cultured human endothelial cells, without causing platelet deposition at non-endothelialized sites. Adhesion of endothelial cells onto polyethylene coated with monoclonal antibodies directed against endothelial cell-specific membrane antigens, integrin receptors and glycoprotein CD31 was equal to or higher than adhesion onto fibronectin-coated polyethylene. Endothelial cells did not proliferate on these surface-adsorbed antibodies. However, pre-coating of polyethylene with mixtures of endothelial cell-specific monoclonal antibodies and monoclonal antibodies directed against fibronectin or von Willebrand factor, resulted in relatively high adhesion and optimal proliferation. Platelet reactivity of the polyethylene surface was found to significantly increase after adsorption of fibronectin, endothelial cell-specific monoclonal antibody or its Fc fragments. In contrast, adsorption of F(ab')2 fragments of endothelial cell-specific monoclonal antibody did not promote platelet deposition. Therefore, it is concluded that coating of vascular graft materials with mixtures of F(ab')2 fragments of monoclonal antibodies specifically directed against endothelial cells and against extracellular matrix proteins may be an effective way to both promote the growth of seeded endothelial cells and limit platelet-graft interaction.
Comparison of the Accuracy of Impedance Plethysmography and Compression Ultrasonography in Outpatients with Clinically Suspected Deep Vein Thrombosis
Authors: Wells Philip S , Hirsh Jack , Anderson David R , Lensing Anthonie W A , Foster Gary , Kearon Clive , Weitz Jeffrey , Cogo Alberto , Prandoni Paolo , Minuk Terry , Thomson Graham , Benedetti Lino , Girolami Antonio 
Published: July 2018

SummaryImpedance plethysmography (IPG) and compression ultrasonography (CUS) have been reported to be highly accurate for the diagnosis of deep vein thrombosis (DVT) in symptomatic patients. In many centres CUS has become the method of choice. However, direct comparisons of the accuracy of IPG to CUS have not been performed. To determine the test of choice we performed a two centre prospective comparison of IPG and CUS, with venography, and determined how the size and distribution of thrombi influenced the accuracy of each test. 495 symptomatic outpatients with suspected DVT had evaluable venograms. The prevalence of DVT was 27% (130/495), 84% (109) of which were proximal. The sensitivity of IPG and CUS for proximal vein thrombosis was 77% and 90% respectively (p = .002). The specificity of IPG was 93% whereas the specificity of CUS was 98% (p = 0.04). There were significant differences in accuracy between the two centres as a consequence of differences in the size and location of thrombi. The majority of proximal thrombi not detected by IPG and CUS involved less than 5 cm of the distal half of the popliteal vein and most of these thrombi occurred in one centre. Exclusion of these thrombi from the analysis increases the sensitivity of CUS to 99% (86/87) and IPG to 91% (72/79), for proximal thrombi (p = .019). The positive predictive value of CUS was strongly influenced by the number of abnormal venous segments (three sites were examined); 100% (80/80) if two or three sites were abnormal, but only 68% if a single site was involved. We conclude that: 1) CUS is more accurate than the IPG for the diagnosis of DVT in symptomatic outpatients, and this relationship holds true regardless of the size or location of the DVT, 2) the sensitivities of IPG and CUS are much lower for small proximal DVT, and 3) confirmatory venography is warranted if the abnormality with CUS is limited to one venous segment.
Stimulated Glanzmann’s Thrombasthenia Platelets Produce Microvesicles
Authors: Holme Pål André , Solum Nils Olav , Brosstad Frank , Egberg Nils , Lindahl Tomas L 
Published: July 2018

SummaryThe mechanism of formation of platelet-derived microvesicles remains controversial.The aim of the present work was to study the formation of microvesicles in view of a possible involvement of the GPIIb-IIIa complex, and of exposure of negatively charged phospholipids as procoagulant material on the platelet surface. This was studied in blood from three Glanzmann’s thrombasthenia patients lacking GPIIb-IIIa and healthy blood donors. MAb FN52 against CD9 which activates the complement system and produces microvesicles due to a membrane permeabilization, ADP (9.37 μM), and the thrombin receptor agonist peptide SFLLRN (100 μM) that activates platelets via G-proteins were used as inducers. In a series of experiments platelets were also preincubated with PGE1 (20 μM). The number of liberated microvesicles, as per cent of the total number of particles (including platelets), was measured using flow cytometry with FITC conjugated antibodies against GPIIIa or GPIb. Activation of GPIIb-IIIa was detected as binding of PAC-1, and exposure of aminophospholipids as binding of annexin V. With normal donors, activation of the complement system induced a reversible PAC-1 binding during shape change. A massive binding of annexin V was seen during shape change as an irreversible process, as well as formation of large numbers of microvesicles (60.6 ±2.7%) which continued after reversal of the PAC-1 binding. Preincubation with PGE1 did not prevent binding of annexin V, nor formation of microvesicles (49.5 ± 2.7%), but abolished shape change and PAC-1 binding after complement activation. Thrombasthenic platelets behaved like normal platelets after activation of complement except for lack of PAC-1 binding (also with regard to the effect of PGE1 and microvesicle formation). Stimulation of normal platelets with 100 μM SFLLRN gave 16.3 ± 1.2% microvesicles, and strong PAC-1 and annexin V binding. After preincubation with PGE1 neither PAC-1 nor annexin V binding, nor any significant amount of microvesicles could be detected. SFLLRN activation of the thrombasthenic platelets produced a small but significant number of microvesicles (6.4 ± 0.8%). Incubation of thrombasthenic platelets with SFLLRN after preincubation with PGE1, gave results identical to those of normal platelets. ADP activation of normal platelets gave PAC-1 binding, but no significant annexin V labelling, nor production of microvesicles. Thus, different inducers of the shedding of microvesicles seem to act by different mechanisms. For all inducers there was a strong correlation between the exposure of procoagulant surface and formation of microvesicles, suggesting that the mechanism of microvesicle formation is linked to the exposure of aminophospholipids. The results also show that the GPIIb-IIIa complex is not required for formation of microvesicles after activation of the complement system, but seems to be of importance, but not absolutely required, after stimulation with SFLLRN.
Endotoxin-Induced Intravascular Coagulation in Rabbits:Effect of Tissue Plasminogen Activator vs Urokinase on PAI Generation, Fibrin Deposits and Mortality
Authors: Paloma M J , Páramo J A , Rocha E 
Published: July 2018

SummaryWe have evaluated the effect of plasminogen activators (t-PA and urokinase) on an experimental model of disseminated intravascular coagulation (DIC) in rabbits by injection of 20 μg/kg/h of E. coli lipopolysaccharide during 6 h t-PA (0.2 mg/kg and 0.7 mg/kg), urokinase (3000 U/kg/h) and saline (control) were given simultaneously with endotoxin. Results indicated that urokinase and low dose of t-PA significantly reduced the increase of plasminogen activator inhibitor (PAI) activity observed 2 h after endotoxin (p <0.001). High t-PA dose also diminished the PAI levels at 6 h (p <0.0001). A significant reduction of fibrin deposits in kidneys was observed in both t-PA treated groups as compared with findings in the group of rabbits infused with saline solution (p <0.005), whereas urokinase had no significant effect on the extent of fibrin deposition. Finally, the mortality rate in the control group (70%) was reduced to 50% in rabbits receiving high doses of t-PA. In conclusion, treatment with t-PA resulted in reduced PAI generation, fibrin deposits and mortality in endotoxin-treated rabbits
Surface Adsorption of Factor XI: Association of Adsorption Sites with the Heavy Chain of Activated Factor XI
Authors: Mannhalter Christine , Schiffman Sandra 
Published: July 2018

SummaryThese experiments study surface adsorption of native and activated factor XI using purified radiolabelled human factor XI and trypsin activated factor XI. Both forms of factor XI adsorb not only to glass but also to polypropylene, polyethylene and polystyrene. Albumin (10 mg/ml) markedly reduces adsorption to plastics but not to glass. Sodium dodecyl sulfate prevents adsorption to all surfaces tested. Reduction of 125I-activated factor XI in the presence of sodium dodecyl sulfate yields labelled chains of molecular weight of about 46,000 (heavy chain), 37,000 (light chain) and a further breakdown product of about 26,000. Reduction of activated factor XI in glass or plastic in the absence of sodium dodecyl sulfate yields only light chain and breakdown product in solution; heavy chain is removed by adsorption. Therefore, we conclude that the adsorption site (s) in trypsin activated factor XI and presumably also in native factor XI is (are) located in the heavy chain subunit of the molecule.
A Physiologic Regulator of Collagen-Induced Platelet Aggregation: Inhibition by Clq
Authors: Csákó György , Suba Eva A 
Published: July 2018

SummaryPlatelet aggregations were studied by a turbidimetric method in citrated human platelet-rich plasmas (PRP) in vitro. Human Clq inhibited the aggregations caused by collagens derived from different tissues and species. Clq was needed by weight in comparable quantities to collagen for neutralizing the aggregating effect. The dependence of the inhibitory reaction on the preincubation of platelets with Clq and the differences in the occurrence of aggregating substances in supernatants of PRP triggered with collagen in the presence or absence of Clq, confirmed that Clq exerts its effect by preventing fixation of collagen to platelets. In addition, the high specificity of the inhibitory action of Clq for collagen-induced platelet aggregation was demonstrated by results obtained for testing a variety of aggregating agents in combination with Clq and/or collagen.Since normal concentrations of Clq in the blood are in the range of inhibitory doses of Clq for collagen-induced platelet aggregations in vitro and upon activation of complement Clq is known to dissociate from Cl, it is proposed that Clq may participate in a highly specific manner in regulating platelet reactivity to collagen in vivo.
Stimulated Platelet Aggregation, Thromboxane B2 Formation and Platelet Sensitivity to Prostacyclin - A Critical Evaluation
Authors: Siess Wolfgang , Roth Peter , Weber Peter C 
Published: July 2018

SummaryPlatelets have been implicated in the development of atherosclerotic and thrombotic vascular diseases. Evaluation of platelet aggregation in relation to endogenously formed compounds which affect platelet function may provide information of clinical and pharmacological relevance. We describe a method in which thromboxane B2 (TXB2) formation was analyzed following stimulation of platelet-rich plasma (PRP) with ADP, 1-epinephrine, collagen, and arachidonic acid. In addition, we determined platelet sensitivity to prostacyclin following ADP- and collagen-induced platelet aggregation. The parameters under study were found to depend on the platelet count in PRP, on the type and dose of the aggregating agent used, and on the test time after blood sampling. By standardization of these variables, a reliable method was established which can be used in clinical and pharmacological trials.