bluuebunny/crossref_metadata_2025_split huggingface dataset:
Differences in antigenic sites and other functional regions between genotype A and G mumps virus surface proteins
Authors: Gouma Sigrid , Vermeire Tessa , Van Gucht Steven , Martens Lennart , Hutse Veronik , Cremer Jeroen , Rota Paul A. , Leroux-Roels Geert , Koopmans Marion , van Binnendijk Rob , Vandermarliere Elien 
Published: August 2018

AbstractThe surface proteins of the mumps virus, the fusion protein (F) and haemagglutinin-neuraminidase (HN), are key factors in mumps pathogenesis and are important targets for the immune response during mumps virus infection. We compared the predicted amino acid sequences of the F and HN genes from Dutch mumps virus samples from the pre-vaccine era (1957–1982) with mumps virus genotype G strains (from 2004 onwards). Genotype G is the most frequently detected mumps genotype in recent outbreaks in vaccinated communities, especially in Western Europe, the USA and Japan. Amino acid differences between the Jeryl Lynn vaccine strains (genotype A) and genotype G strains were predominantly located in known B-cell epitopes and in N-linked glycosylation sites on the HN protein. There were eight variable amino acid positions specific to genotype A or genotype G sequences in five known B-cell epitopes of the HN protein. These differences may account for the reported antigenic differences between Jeryl Lynn and genotype G strains. We also found amino acid differences in and near sites on the HN protein that have been reported to play a role in mumps virus pathogenesis. These differences may contribute to the occurrence of genotype G outbreaks in vaccinated communities.
Low Gilbert Damping Constant in Perpendicularly Magnetized W/CoFeB/MgO Films with High Thermal Stability
Authors: Lattery Dustin M. , Zhang Delin , Zhu Jie , Hang Xudong , Wang Jian-Ping , Wang Xiaojia 
Published: August 2018

AbstractPerpendicular magnetic materials with low damping constant and high thermal stability have great potential for realizing high-density, non-volatile, and low-power consumption spintronic devices, which can sustain operation reliability for high processing temperatures. In this work, we study the Gilbert damping constant (α) of perpendicularly magnetized W/CoFeB/MgO films with a high perpendicular magnetic anisotropy (PMA) and superb thermal stability. The α of these PMA films annealed at different temperatures (Tann) is determined via an all-optical Time-Resolved Magneto-Optical Kerr Effect method. We find that α of these W/CoFeB/MgO PMA films decreases with increasing Tann, reaches a minimum of α = 0.015 at Tann = 350 °C, and then increases to 0.020 after post-annealing at 400 °C. The minimum α observed at 350 °C is rationalized by two competing effects as Tann becomes higher: the enhanced crystallization of CoFeB and dead-layer growth occurring at the two interfaces of the CoFeB layer. We further demonstrate that α of the 400 °C-annealed W/CoFeB/MgO film is comparable to that of a reference Ta/CoFeB/MgO PMA film annealed at 300 °C, justifying the enhanced thermal stability of the W-seeded CoFeB films.
The transcription factor SoxD controls neuronal guidance in the Drosophila visual system
Authors: Contreras Esteban G. , Palominos Tomás , Glavic Álvaro , Brand Andrea H. , Sierralta Jimena , Oliva Carlos 
Published: August 2018

AbstractPrecise control of neurite guidance during development is essential to ensure proper formation of neuronal networks and correct function of the central nervous system (CNS). How neuronal projections find their targets to generate appropriate synapses is not entirely understood. Although transcription factors are key molecules during neurogenesis, we do not know their entire function during the formation of networks in the CNS. Here, we used the Drosophila melanogaster optic lobe as a model for understanding neurite guidance during development. We assessed the function of Sox102F/SoxD, the unique Drosophila orthologue of the vertebrate SoxD family of transcription factors. SoxD is expressed in immature and mature neurons in the larval and adult lobula plate ganglia (one of the optic lobe neuropils), but is absent from glial cells, neural stem cells and progenitors of the lobula plate. SoxD RNAi knockdown in all neurons results in a reduction of the lobula plate neuropil, without affecting neuronal fate. This morphological defect is associated with an impaired optomotor response of adult flies. Moreover, knocking down SoxD only in T4/T5 neuronal types, which control motion vision, affects proper neurite guidance into the medulla and lobula. Our findings suggest that SoxD regulates neurite guidance, without affecting neuronal fate.
Mn-induced Ferromagnetic Semiconducting Behavior with Linear Negative Magnetoresistance in Sr4(Ru1−xMnx)3O10 Single Crystals
Authors: Xing Lingyi , Gui Xin , Xie Weiwei , Cao Huibo , Yan Jiaqiang , Sales Brian C. , Jin Rongying 
Published: August 2018

AbstractTriple-layered Sr4Ru3O10 is a unique ferromagnet with the central RuO6 layer behaving differently from two outer layers both crystallographically and magnetically. We report that the partial substitution of Ru by smaller Mn gives rise to modification in crystal structure, electronic and magnetic properties of Sr4(Ru1−xMnx)3O10. Through the single crystal X-ray diffraction refinement, we find that (Ru/Mn)O6 octahedral rotation is no longer detectable at x ≥ 0.23, leading to the tetragonal structure. The magnetization measurements indicate the ferromagnetic transition temperature TC decreases from 105 K for x = 0 to 30 K for x = 0.41, with the reduced magnetic moment as well. Remarkably, Mn doping results in the change of magnetic anisotropy from the easy c axis in x = 0 to the easy ab plane seen in x = 0.34 and 0.41. Such change also removes the ab-plane metamagnetic transition observed in x = 0. Furthermore, the electrical resistivity increases with increasing x showing semiconducting behavior with Δ ~ 10 meV for x = 0.34 and 30 meV for x = 0.41. Under applied magnetic field, the magnetoresistance exhibits negative and linear field dependence in all current and field configurations. These results clearly indicate Sr4(Ru1−xMnx)3O10 is a novel ferromagnetic semiconductor with exotic magnetotransport properties.
The quaternary structure of Thermus thermophilus aldehyde dehydrogenase is stabilized by an evolutionary distinct C-terminal arm extension
Authors: Hayes Kevin , Noor Mohamed , Djeghader Ahmed , Armshaw Patricia , Pembroke Tony , Tofail Syed , Soulimane Tewfik 
Published: August 2018

AbstractAldehyde dehydrogenases (ALDH) form a superfamily of dimeric or tetrameric enzymes that catalyze the oxidation of a broad range of aldehydes into their corresponding carboxylic acids with the concomitant reduction of the cofactor NAD(P) into NAD(P)H. Despite their varied polypeptide chain length and oligomerisation states, ALDHs possess a conserved architecture of three domains: the catalytic domain, NAD(P)+ binding domain, and the oligomerization domain. Here, we describe the structure and function of the ALDH from Thermus thermophilus (ALDHTt) which exhibits non-canonical features of both dimeric and tetrameric ALDH and a previously uncharacterized C-terminal arm extension forming novel interactions with the N-terminus in the quaternary structure. This unusual tail also interacts closely with the substrate entry tunnel in each monomer providing further mechanistic detail for the recent discovery of tail-mediated activity regulation in ALDH. However, due to the novel distal extension of the tail of ALDHTt and stabilizing termini-interactions, the current model of tail-mediated substrate access is not apparent in ALDHTt. The discovery of such a long tail in a deeply and early branching phylum such as Deinococcus-Thermus indicates that ALDHTt may be an ancestral or primordial metabolic model of study. This structure provides invaluable evidence of how metabolic regulation has evolved and provides a link to early enzyme regulatory adaptations.
Route towards extreme optical pulsation in linear cavity ultrafast fibre lasers
Authors: Akosman Ahmet E. , Sander Michelle Y. 
Published: August 2018

AbstractPathways towards the generation of extreme optical pulsation in a chaotic transition regime in a linear fibre laser cavity configuration are presented. In a thulium mode-locked fibre laser, extreme events that can be controllably induced by manipulating the cavity birefringence for pulse energies exceeding the single soliton pulse operating regime are studied in detail for the first time. While a solitonic pulsation structure at the fundamental repetition rate is maintained, additional energy is shed in a chaotic manner, leading to broader spectral generation and shorter pulse durations whose behaviour deviates significantly from a classical statistical distribution. These pulses display markedly different characteristics from any previously reported extreme events in fibre lasers associated with multiple solitons and pulse bunching, thus presenting a novel observation of extreme pulsation. Detailed noise studies indicate that significant enhancement of relaxation oscillations, modulation instability and the interplay with reabsorption mechanisms contribute in this transient chaotic regime. The extreme pulsation generated in a compact fibre laser without any additional nonlinear attractors can provide an attractive platform to accelerate the exploration of the underlying physics of the chaos observed in mode-locked laser systems and can lead to novel fibre laser cavity designs.
Magnetic fields in Bok globules: multi-wavelength polarimetry as tracer across large spatial scales
Authors: Jorquera S. , Bertrang G. H.-M. 
Published: August 2018

Context. The role of magnetic fields in the process of star formation is a matter of continuous debate. Clear observational proof of the general influence of magnetic fields on the early phase of cloud collapse is still pending. In an earlier study on Bok globules with simple structures, we find strong indications of dominant magnetic fields across large spatial scales.
Aims. The aim of this study is to test the magnetic field influence across Bok globules with more complex density structures.
Methods. We apply near-infrared polarimetry to trace the magnetic field structure on scales of 104–105 au (~0.05–0.5pc) in selected Bok globules. The combination of these measurements with archival data in the optical and sub-mm wavelength range allows us to characterize the magnetic field on scales of 103–106 au (~0.005–5pc).
Results. We present polarimetric data in the near-infrared wavelength range for the three Bok globules CB34, CB56, and [OMK2002]18, combined with archival polarimetric data in the optical wavelength range for CB34 and CB56, and in the submillimeter wavelength range for CB34 and [OMK2002]18. We find a strong polarization signal (P ≥ 2%) in the near-infrared for all three globules. For CB34, we detect a connection between the structure on scales of 104–105 au (~0.05–0.5pc) to 105–106 au (~0.5–5pc). For CB56, we trace aligned polarization segments in both the near-infrared and optical data, suggesting a connection of the magnetic field structure across the whole globule. In the case of [OMK2002]18, we find ordered polarization structures on scales of 104–105 au (~0.05–0.5pc).
Conclusions. We find strongly aligned polarization segments on large scales which indicate dominant magnetic fields across Bok globules with complex density structures. To reconcile our findings in globules, the lowest mass clouds known, and the results on intermediate (e.g. Taurus) and more massive (e.g. Orion) clouds, we postulate a mass-dependent role of magnetic fields, whereby magnetic fields appear to be dominant on low and high mass but rather subdominant on intermediate mass clouds.
The XXL Survey
Authors: Ciliegi Paolo , Jurlin Nika , Butler Andrew , Delhaize Jacinta , Fotopoulou Sotiria , Huynh Minh , Iovino Angela , Smolčić Vernesa , Chiappetti Lucio , Pierre Marguerite 
Published: August 2018

Context. To investigate the nature of the extragalactic radio sources, it is necessary to couple radio surveys with multiwavelength observations over large areas of the sky. The XMM-Newton Extragalactic (XXL) survey is the largest survey ever undertaken with the XMM-Newton X-ray telescope over two separate fields of 25 deg2 each (XXL-N and XXL-S). At the same time the XXL survey benefits from a wealth of ancillary data spanning from the far-ultraviolet to the mid-infrared.
Aims. In this paper we present the optical, near-infrared (NIR), and X-ray identifications of the 6287 radio sources detected in the 2.1 GHz deep radio survey down to a median rms of σ ≈ 41 μJy beam−1 obtained with the Australia Telescope Compact Array (ATCA) in the XXL-S field. The goal of this paper is to provide a multiwavelength catalogue of the counterparts of the radio sources to be used in further studies.
Methods. For the optical and NIR identification of the radio sources, we used the likelihood ratio (LR) technique, slightly modified in order to take into account the presence of a large number of relatively bright counterparts close to the radio sources. The LR technique was applied to seven optical bands (gBCS, gDec, rBCS, rDec, iBCS, iDec, zDec) and to three NIR bands (J, H, K).
Results. The ten different photometric catalogues have been combined into a single master catalogue where all the photometric information in the optical, NIR, and X-ray bands have been collected for the counterparts of the radio sources. This procedure led to the identification of optical/NIR counterparts for 4770 different radio sources (~77% of the whole radio sample), 414 of which also have an X-ray counterpart. This fraction of identification is in agreement with previous radio-optical association studies at a similar optical magnitude depth, but is relatively low in comparison to recent work conducted in other radio fields using deeper optical and NIR data.
Conclusions. The analysis of optical and NIR properties of radio sources shows that, regardless of the radio flux limit of a radio survey, the nature of the identified sources is strongly dependent on the depth of the optical/NIR used in the identification process. Only with deep enough optical/NIR data will we be able to identify a significant fraction of radio sources with red (zDec-K) counterparts whose radio emission is dominated by nuclear activity rather than starburst activity.
Quantification of Phenolic Compounds from Fadogia agrestis and Dietary Supplements using UHPLC-PDA-MS
Authors: Avula Bharathi , Bae Ji-Yeong , Raman Vijayasankar , Fantoukh Omer , Wang Yan-Hong , Osman Ahmed , Wang Mei , Ali Zulfiqar , Khan Ikhlas 
Published: August 2018

Abstract
Fadogia agrestis is used in traditional African medicine as an analgesic and for anti-inflammatory and aphrodisiac activities. An ultra-high-performance liquid chromatography method was developed for the determination of 11 chemical constituents from roots and aerial parts of F. agrestis. The separation was achieved within 7 min by using C-18 column material and a water/acetonitrile mobile phase, both containing 0.1% formic acid gradient system with a temperature of 45 °C. The method was validated for linearity, repeatability, limits of detection, and limits of quantification. The limits of detection of phenolic compounds were found to be in the range from 0.025 to 0.1 µg/mL. The wavelengths used for quantification with the photodiode array detector were 238, 254, 291, and 325 nm. Twelve of 17 dietary supplements contained phenolic compounds in the range from 0.3 to 2.7 mg/d. The phenolic compounds were not detected in five dietary supplements. Liquid chromatography-mass spectrometry coupled with electrospray ionization interface method is described for the identification and confirmation of compounds from plant samples and dietary supplements claiming to contain F. agrestis. This method involved the use of [M + H]+ and [M + Na]+ ions in the positive mode and [M − H]− ions in the negative mode with extractive ion monitoring. The developed method is simple, economic, rapid, and especially suitable for quality control and chemical fingerprint analysis of F. agrestis.
Vasopressin-Induced Ventricular Arrhythmia
Authors: Ghanta Soma , Parvathaneni Sarada , Koduru Gopala , Palaparthi Sudarshan , Palaparthi Raghuram , Rao Kondru Purna 
Published: August 2018

AbstractLong QT and ventricular tachyarrhythmias can occur due to a number of causes including dyselectrolytemia, drugs, and intracranial lesions, predominantly subarachnoid hemorrhage. Here the authors report a rare case of acquired long QT with R on T ventricular ectopics due to vasopressin in the setting of intracerebral bleed, which reverted on withdrawal of vasopressin.
Endovascular Management of Cerebral Aneurysm: The Recent Trends
Authors: Gupta Vipul , Londhe Shrikant , Parthasarathy Rajsrinivas , Ganaie Hilal 
Published: August 2018

AbstractCerebral aneurysm rupture is the leading cause of mortality and morbidity in patients with hemorrhagic stroke. Surgical clipping and endovascular coiling are the mainstay of management for securing the aneurysm. After International Subarachnoid Aneurysm Trial (ISAT) and Barrow Ruptured Aneurysm Trial (BRAT) results, worldwide trend has shifted gradually in favor of endovascular management. Nonetheless, endovascular management was faced with some limitations, especially while treating giant, wide neck bifurcation, blister, and small uncoilable aneurysm. The recent introduction of new devices such as flow diverter stents, microstents, bifurcation devices, double-lumen balloon catheters, and microcoils have proved to be effective in overcoming the limitations of traditional aneurysm coiling. The authors present a review of recent advances in the endovascular management of cerebral aneurysm.
Conservative Management of Subacute Contained Left Ventricular Rupture after Acute Myocardial Infarction
Authors: Goud C Bharat , Christopher Johann 
Published: August 2018

AbstractLeft ventricular free wall rupture (LVFWR) is a near-fatal mechanical complication of acute myocardial infarction in which an early diagnosis and emergency surgery should be of utmost priority for successful treatment. LVFWR is generally perceived to be universally fatal. Majority of LVFWR patients developing cardiac tamponade die rapidly, while in minority of cases the development of tamponade may be sufficiently slow to allow for diagnosis and successful intervention. In this article, the authors report a case of a 63-year-old male patient diagnosed with an inferoposterior wall myocardial infarction treated with early reperfusion thrombolytic therapy presenting 3 days later with diagnosis of subacute LVFWR. Patient had a history of relapse of chest pain which was severe and prolonged with 2 to 3 mm saddle-shaped ST-segment elevation in lateral leads, detected on a routine electrocardiogram, which led to an urgent bedside transthoracic echocardiogram (TTE). TTE showed regional wall motion abnormality in form of akinetic basal inferior-wall, a small echodense pericardial effusion, and a canalicular tract from endocardium to pericardium, through which color-Doppler examination suggested blood crossing the myocardial wall. A cardiac magnetic resonance imaging further reinforced the possibility of contained LVFWR.
NMR screening and studies of target – ligand interactions
Authors: Polshakov Vladimir I. , Batuev Evgeniy A. , Mantsyzov Alexey B. 
Published: August 2018

Nuclear magnetic resonance (NMR) spectroscopy is one of the leading biophysical methods used in the search for and design of physiologically active compounds considered as potential drugs. The review concerns modern NMR techniques used to study the binding of low-molecular-mass compounds to biomacromolecular targets. The most promising methods of NMR screening and strategies for rational lead design are discussed. They were used to design drugs that have been approved for the use in medical practice or are in the final stages of clinical trials. Examples are given of the application of the fragment-based drug design and NMR screening techniques to the design of novel drugs.The bibliography includes 252 references.
Competition policy and economics
Authors: Whish Richard , Bailey David 
Published: August 2018

Abstract
This chapter provides an overview of competition law and its economic context. Section 2 describes the practices that competition laws attempt to control in order to protect the competition process. Section 3 examines the theory of competition and gives an introductory account of why the effective enforcement of competition law is thought to be beneficial for consumer welfare. Section 4 considers the expected functions of a system of competition law. Section 5 then introduces two key economic concepts, market definition and market power, that are important to a better understanding of competition policy. The chapter concludes with a table of market share figures that are significant in the application of EU and UK competition law.
Article 102
Authors: Whish Richard , Bailey David 
Published: August 2018

Abstract
This chapter discusses the main features of Article 102 of the Treaty on the Functioning of the European Union (TFEU), which is concerned with the abusive conduct of dominant firms. It begins by introducing the European Commission’s Guidance on the Commission’s enforcement priorities in applying Article [102 TFEU] to abusive exclusionary conduct by dominant undertakings. It then discusses the concept of undertaking, the requirement of an effect on trade between Member States, the concept of a dominant position and the requirement that any dominant position must be held in a substantial part of the internal market. The chapter also considers the meaning of abuse of a dominant position, which is a complex and controversial issue. A discussion of the defences to allegations of abuse is followed by a brief look at the consequences of infringing Article 102.
Articles 101 and 102: public enforcement by the European Commission and national competition authorities under Regulation 1/2003
Authors: Whish Richard , Bailey David 
Published: August 2018

Abstract
This chapter explains the public enforcement of Articles 101 and 102 by the European Commission and the national competition authorities (‘the NCAs’) under Regulation 1/2003. It begins by describing the Commission’s powers of investigation and enforcement, including its power to accept commitments, its leniency programme, the cartel settlement procedure and its power to impose financial penalties. It then discusses the operation of Regulation 1/2003 in practice, with particular reference to the European Competition Network (‘the ECN’) that brings together the Commission and the NCAs. The chapter concludes by providing a brief account of judicial review of the Commission’s decisions.
Horizontal agreements (2): oligopoly, tacit collusion and collective dominance
Authors: Whish Richard , Bailey David 
Published: August 2018

Abstract
This chapter describes how competition law addresses oligopoly, tacit collusion and collective dominance. This chapter is concerned with the related topics of oligopoly, tacit collusion and collective dominance. Oligopoly exists where a few firms between them supply all or most of the goods or services on a market without any of them having a clear ascendancy over the others. This chapter begins with discussion of the theory of oligopolistic interdependence and of the possible ways of dealing with the ‘oligopoly problem’. It then considers the extent to which Articles 101 and 102 can be used to address that problem. The chapter also discusses UK law and, in particular, the possible use of market investigations to address market failure that may arise in oligopolies.