bluuebunny/crossref_metadata_2025_split huggingface dataset:
Oblique Thrusting and Strain Partitioning in the Longmen Shan Fold‐and‐Thrust Belt, Eastern Tibetan Plateau
Authors: Li Zhigang , Zhang Peizhen , Zheng Wenjun , Jia Dong , Hubbard Judith , Almeida Rafael , Sun Chuang , Shi Xuhua , Li Tao 
Published: May 2018

AbstractEastern Tibet is an important example of oblique convergence and associated strain partitioning, as suggested by recent 2‐D and 3‐D structural interpretations, yet the nature and evolution of oblique strain partitioning of this region remain poorly known. Here we use seismic reflection profiles, borehole data, and field investigations in the Longmen Shan piedmont to determine the subsurface structural architecture, and we observe several nearly N‐S striking thrusts and reactivation of NE striking preexisting faults. We interpret that this behavior is due to a regional principal compressional stress oriented in the E‐W direction, oblique to the NE striking Longmen Shan. Using the records of fault activity and related Late Pliocene and Quaternary foreland sediments and growth strata, as well as the coseismic rupture of the 2008Mw7.9 Wenchuan earthquake, we demonstrate that the Longmen Shan has experienced E‐W crustal shortening and oblique motion since ~5–2 Ma. We present two strain partitioning models arising from oblique thrusting in eastern Tibet and suggest that the eastward extrusion from Tibet is mainly accommodated on the strike‐slip Longriba fault and the dip‐slip Longmen Shan‐Min Shan fault zones. These results enhance our understanding of the tectonic relationship between the Songpan‐Ganzi terrane and the Sichuan basin and provide additional constraints for studies of the geodynamic response of eastern Tibet to the ongoing India‐Eurasia collision.
Integration of large-scale data for extraction of integrated Arabidopsis root cell-type specific models
Authors: Scheunemann Michael , Brady Siobhan M. , Nikoloski Zoran 
Published: May 2018

AbstractPlant organs consist of multiple cell types that do not operate in isolation, but communicate with each other to maintain proper functions. Here, we extract models specific to three developmental stages of eight root cell types or tissue layers in Arabidopsis thaliana based on a state-of-the-art constraint-based modeling approach with all publicly available transcriptomics and metabolomics data from this system to date. We integrate these models into a multi-cell root model which we investigate with respect to network structure, distribution of fluxes, and concordance to transcriptomics and proteomics data. From a methodological point, we show that the coupling of tissue-specific models in a multi-tissue model yields a higher specificity of the interconnected models with respect to network structure and flux distributions. We use the extracted models to predict and investigate the flux of the growth hormone indole-3-actetate and its antagonist, trans-Zeatin, through the root. While some of predictions are in line with experimental evidence, constraints other than those coming from the metabolic level may be necessary to replicate the flow of indole-3-actetate from other simulation studies. Therefore, our work provides the means for data-driven multi-tissue metabolic model extraction of other Arabidopsis organs in the constraint-based modeling framework.
Characterization of the rat cerebrospinal fluid proteome following acute cerebral ischemia using an aptamer-based proteomic technology
Authors: Simats Alba , García-Berrocoso Teresa , Ramiro Laura , Giralt Dolors , Gill Natalia , Penalba Anna , Bustamante Alejandro , Rosell Anna , Montaner Joan 
Published: May 2018

AbstractThe limited accessibility to the brain has turned the cerebrospinal fluid (CSF) into a valuable source that may contribute to the complete understanding of the stroke pathophysiology. Here we have described the CSF proteome in the hyper-acute phase of cerebral ischemia by performing an aptamer-based proteomic assay (SOMAscan) in CSF samples collected before and 30 min after male Wistar rats had undergone a 90 min Middle Cerebral Artery Occlusion (MCAO) or sham-surgery. Proteomic results indicated that cerebral ischemia acutely increased the CSF levels of 716 proteins, mostly overrepresented in leukocyte chemotaxis and neuronal death processes. Seven promising candidates were further evaluated in rat plasma and brain (CKB, CaMK2A, CaMK2B, CaMK2D, PDXP, AREG, CMPK). The 3 CaMK2 family-members and CMPK early decreased in the infarcted brain area and, together with AREG, co-localized with neurons. Conversely, CKB levels remained consistent after the insult and specifically matched with astrocytes. Further exploration of these candidates in human plasma revealed the potential of CKB and CMPK to diagnose stroke, while CaMK2B and CMPK resulted feasible biomarkers of functional stroke outcome. Our findings provided insights into the CSF proteome following cerebral ischemia and identified new outstanding proteins that might be further considered as potential biomarkers of stroke.
Chronic Subdural Hematoma Surgical Evacuation with Burr-Hole Drainage: An Institutional Experience
Authors: Gupta Ashok , Sinha Virendra Deo , Agrawal Yogesh 
Published: May 2018

Abstract
Background Chronic SDH (CSDH) is one of the most common clinical entities in neurosurgery with most favorable prognosis commonly encountered in elderly patients with history of minor trauma and surgery is gold standard treatment.
Objectives This study was done to evaluate the clinical presentation, radiologic findings, complications, and management of patients with CSDH who were treated surgically with burr-hole evacuation.
Materials and Methods This prospective study was done in Department of Neuro-surgery, SMS Medical College, Jaipur, India, from September 2015 to April 2016. The sample size was 55.
Results In this study out of 55 patients, 39 (71%) patients were male and 16 (29%) were female. The most common age group in which CSDH observed was between 61 and 70 years. Most common presenting symptom was headache present in 30 (54.55%) patients followed by weakness. Midline shift more than 5 mm was seen in 43 (78%) patients. The most common complication was recurrence of CSDH (5.4%) in our study. Recurrence after single burr hole was 16.6% and 4.1% after double burr holes. Simple pneumocephalus was present in almost all cases and tension pneumocephalus was found in one (1.8%) patient.
Conclusion Complete evacuation of unilateral CSDH by two burr holes at highest point of hematoma is sufficient. Factors affecting recurrence rate include old age, gross midline shift, and single burr hole. Postoperative simple pneumocephalus is a common radiologic finding that requires no treatment and it does not affect ultimate outcome. Tension pneumocephalus is a serious complication requiring emergent treatment.
Interest of Combined Blood Pressure Measurements in Very Old Frail Subjects: The PARTAGE Study
Authors: Mourad Jean-Jacques , Agnoletti Davide , Labat Carlos , Gautier Sylvie , Salvi Paolo , Valbusa Filippo , Hanon Olivier , Toulza Olivier , Manckoundia Patrick , Fantin Francesco , Rolland Yves , Benetos Athanase 
Published: May 2018

Abstract

BACKGROUND
Several clinical studies have shown that blood pressure (BP) measurements in very old frail individuals are of limited interest due to the fact that several age-related alterations and geriatric syndromes may modify BP. We studied in persons over 80-year old living in nursing homes the combined effects of 3 BP patterns on total mortality and major cardiovascular (CV) events: (i) low pulse pressure amplification (L-PPA) between carotid and brachial artery, (ii) systolic BP (SBP) &lt;130 mm Hg (L-SBP), under &gt;1 antihypertensive drugs, and (iii) changes in SBP between supine and upright position of &gt;20 mm Hg in both directions (hypotension/hypertension, orthostatic SBP [O-SBP]).

METHODS
This analysis was performed in subjects of the PARTAGE study presenting all these 3 measurements (n = 883). The combined effects of L-PPA, L-SBP, and O-SBP were studied during the 2 years followed-up period.

RESULTS
After adjusting for age, sex, and history of CV events, all 3 BP patterns were independent determinants of major CV events (L-PPA, (P = 0.023); L-SBP, (P = 0.050); O-SBP, (P = 0.015)), whereas L-PPA (P = 0.012) and L-SBP (P = 0.006) were also independent determinants of total mortality. Compared with the subjects without any BP pattern, the presence of 2 or 3 BP patterns was associated with an increase in total mortality and major CV events greater than 2 and 2.5 times, respectively.

CONCLUSIONS
In very old frail subjects, there is a particular interest for using different BP measurement approaches, than in younger populations, in order to evaluate the risks related to the BP levels.

CLINICAL TRIALS REGISTRATION
Trial Number: NCT00901355 (Clinical Trials.gov).
Combining probabilistic alignments with read pair information improves accuracy of split-alignments
Authors: Shrestha Anish M S , Yoshikawa Naruki , Asai Kiyoshi 
Published: May 2018

Abstract

Motivation
Split-alignments provide base-pair-resolution evidence of genomic rearrangements. In practice, they are found by first computing high-scoring local alignments, parts of which are then combined into a split-alignment. This approach is challenging when aligning a short read to a large and repetitive reference, as it tends to produce many spurious local alignments leading to ambiguities in identifying the correct split-alignment. This problem is further exacerbated by the fact that rearrangements tend to occur in repeat-rich regions.

Results
We propose a split-alignment technique that combats the issue of ambiguous alignments by combining information from probabilistic alignment with positional information from paired-end reads. We demonstrate that our method finds accurate split-alignments, and that this translates into improved performance of variant-calling tools that rely on split-alignments.

Availability and implementation
An open-source implementation is freely available at: https://bitbucket.org/splitpairedend/last-split-pe.

Supplementary information
Supplementary data are available at Bioinformatics online.
Rotavirus Vaccination Is Associated With Reduced Seizure Hospitalization Risk Among Commercially Insured US Children
Authors: Burke Rachel M , Tate Jacqueline E , Dahl Rebecca Moritz , Aliabadi Negar , Parashar Umesh D 
Published: May 2018

Abstract
Rotavirus commonly causes diarrhea but can also cause seizures. Analysis of insurance claims for 1773295 US children with 2950 recorded seizures found that, compared to rotavirus-unvaccinated children, seizure hospitalization risk was reduced by 24% (95% confidence interval [CI], 13%–33%) and 14% (95% CI, 0%–26%) among fully and partially rotavirus-vaccinated children, respectively.
Algebraic Cycles and Residues of Degree 8 L-functions of GSp(4) × GL(2)
Authors: Lemma Francesco 
Published: May 2018

Abstract
We prove a cohomological formula for noncritical residues of degree 8 automorphic $L$-functions of $\mathrm{GSp}(4) \times \mathrm{GL}(2)$ in the spirit of Beilinson conjecture. We rely on the cohomological interpretation of an automorphic period integral and on the study of Novodvorsky’s integral representation of the $L$-functions.
Lp Norms of Eigenfunctions on Regular Graphs and on the Sphere
Authors: Brooks Shimon , Le Masson Etienne 
Published: May 2018

Abstract
We prove upper bounds on the $L^p$ norms of eigenfunctions of the discrete Laplacian on regular graphs. We then apply these ideas to study the $L^p$ norms of joint eigenfunctions of the Laplacian and an averaging operator over a finite collection of algebraic rotations of the two-sphere. Under mild conditions, such joint eigenfunctions are shown to satisfy for large $p$ the same bounds as those known for Laplace eigenfunctions on a surface of non-positive curvature.
Infectious MERS-CoV Isolated From a Mildly Ill Patient, Saudi Arabia
Authors: Al-Abdely Hail M , Midgley Claire M , Alkhamis Abdulrahim M , Abedi Glen R , Tamin Azaibi , Binder Alison M , Alanazi Khalid , Lu Xiaoyan , Abdalla Osman , Sakthivel Senthilkumar K , Mohammed Mutaz , Queen Krista , Algarni Homoud S , Li Yan , Trivedi Suvang , Algwizani Abdullah , Alhakeem Raafat F , Thornburg Natalie J , Tong Suxiang , Ghazal Sameeh S , Erdman Dean D , Assiri Abdullah M , Gerber Susan I , Watson John T 
Published: May 2018

Abstract
Middle East respiratory syndrome coronavirus (MERS-CoV) is associated with a wide range of clinical presentations, from asymptomatic or mildly ill to severe respiratory illness including death. We describe isolation of infectious MERS-CoV from the upper respiratory tract of a mildly ill 27-year-old female in Saudi Arabia 15 days after illness onset.
Discovery of recombining plasma from the faintest GeV supernova remnant HB 21 and a possible scenario for cosmic rays escaping from supernova remnant shocks
Authors: Suzuki Hiromasa , Bamba Aya , Nakazawa Kazuhiro , Furuta Yoshihiro , Sawada Makoto , Yamazaki Ryo , Koyama Katsuji 
Published: May 2018

Abstract
We present an X-ray study of the GeV gamma-ray supernova remnant (SNR) HB 21 with Suzaku. HB 21 is interacting with molecular clouds, and is the faintest in the GeV band among known GeV SNRs. We discovered strong radiative recombination continua of Si and S from the center of the remnant, which provide direct evidence of a recombining plasma (RP). The total emission can be explained with the RP and ionizing plasma components. The electron temperature and recombination timescale of the RP component were estimated as 0.17 (0.15–0.18) keV and 3.2 (2.0–4.8) × 1011 s cm−3, respectively. The estimated age of the RP (∼170 kyr) is the longest among known recombining GeV SNRs, because of a very low density of electrons (∼0.05 cm−3). We have examined the dependencies of GeV spectral indices on each of RP ages and SNR diameters for nine recombining GeV SNRs. Both showed possible positive correlations, indicating that both the parameters can be good indicators of properties of accelerated protons, for instance the degree of escape from SNR shocks. A possible scenario for a process of proton escape is introduced: interaction with molecular clouds makes weaker magnetic turbulence and cosmic-ray protons escape, simultaneously cooling down the thermal electrons and generating an RP.
Multiple Sequence Alignment Averaging Improves Phylogeny Reconstruction
Authors: Ashkenazy Haim , Sela Itamar , Levy Karin Eli , Landan Giddy , Pupko Tal 
Published: May 2018

Abstract
The classic methodology of inferring a phylogenetic tree from sequence data is composed of two steps. First, a multiple sequence alignment (MSA) is computed. Then, a tree is reconstructed assuming the MSA is correct. Yet, inferred MSAs were shown to be inaccurate and alignment errors reduce tree inference accuracy. It was previously proposed that filtering unreliable alignment regions can increase the accuracy of tree inference. However, it was also demonstrated that the benefit of this filtering is often obscured by the resulting loss of phylogenetic signal. In this work we explore an approach, in which instead of relying on a single MSA, we generate a large set of alternative MSAs and concatenate them into a single SuperMSA. By doing so, we account for phylogenetic signals contained in columns that are not present in the single MSA computed by alignment algorithms. Using simulations, we demonstrate that this approach results, on average, in more accurate trees compared to 1) using an unfiltered MSA and 2) using a single MSA with weights assigned to columns according to their reliability. Next, we explore in which regions of the MSA space our approach is expected to be beneficial. Finally, we provide a simple criterion for deciding whether or not the extra effort of computing a SuperMSA and inferring a tree from it is beneficial. Based on these assessments, we expect our methodology to be useful for many cases in which diverged sequences are analyzed. The option to generate such a SuperMSA is available at http://guidance.tau.ac.il.
Tinnitus Severity Is Related to the Sound Exposure of Symphony Orchestra Musicians Independently of Hearing Impairment
Authors: Schmidt Jesper Hvass , Paarup Helene M. , Bælum Jesper 
Published: May 2018

Objectives:
Tinnitus can be debilitating and with great impact of musicians professional and private life. The objectives of the study were therefore to: (1) describe the epidemiology of tinnitus including its severity in classical orchestra musicians, (2) investigate the association between tinnitus severity in classical musicians and their cumulative lifetime sound exposure, and (3) the association between tinnitus and hearing thresholds.

Design:
The study population included all musicians from five Danish symphony orchestras. Answers regarding their perception of tinnitus were received from 325 musicians, and 212 musicians were also tested with audiometry. Any tinnitus and severe tinnitus were two definitions of tinnitus used as outcomes and analyzed in relation to an estimation of the cumulative lifetime sound exposure from sound measurements and previously validated questionnaires and the average hearing threshold of 3, 4, and 6 kHz.

Results:
Thirty-five percentage of all musicians (31% female and 38% of male musicians) reported having experienced at least one episode of tinnitus lasting for more than 5 minutes during their life. Severe tinnitus with a severe impact on daily life was reported by 19% of the musicians (18% of female and 21% of male musicians). The severity of tinnitus was associated with increased lifetime sound exposure but not to poorer high frequency hearing thresholds when the lifetime sound exposure was considered. The odds ratio for an increase in one unit of tinnitus severity was 1.25 (95% CI, 1.12–1.40) for every 1 dB increase in lifetime sound exposure.

Conclusion:
Musicians frequently report tinnitus. Any tinnitus and severe tinnitus are significantly associated with the cumulative lifetime sound exposure, which was shown to be the most important factor not only for the prevalence but also for the severity of tinnitus—even in musicians without hearing loss. High-frequency hearing thresholds and tinnitus severity were correlated only if the cumulative lifetime sound exposure was excluded from the analyses.
Are You There for Me? Joint Engagement and Emotional Availability in Parent–Child Interactions for Toddlers With Moderate Hearing Loss
Authors: Dirks Evelien , Rieffe Carolien 
Published: May 2018

Objectives:
This study examined joint engagement and emotional availability of parent–child interactions for toddlers with moderate hearing loss (MHL) compared with toddlers with normal hearing (NH) and in relation to children’s language abilities.

Design:
The participants in this study were 25 children with MHL (40 to 60 dB hearing loss) and 26 children with NH (mean age: 33.3 months). The children and their parents were filmed during a 10-minute free play session in their homes. The duration of joint engagement and success rate of initiations were coded next to the level of emotional availability reflected by the Emotional Availability Scales. Receptive and expressive language tests were administered to the children to examine their language ability.

Results:
Groups differed in joint engagement: children with MHL and their parents were less successful in establishing joint engagement and had briefer episodes of joint engagement than children with NH and their parents. No differences between groups were found for emotional availability measures. Both joint engagement and emotional availability measures were positively related to children’s language ability.

Conclusions:
Children with MHL and their parents are emotional available to each other. However, they have more difficulties in establishing joint engagement with each other and have briefer episodes of joint engagement compared with children with NH and their parents. The parent–child interactions of children with better language abilities are characterized with higher levels of emotional availability and longer episodes of joint engagement. The results imply that interactions of children with MHL and their parents are an important target for family-centered early intervention programs.
An Exploration of the Impact of the “Open Gym” Scheduling Model of Cardiovascular Rehabilitation on Completion, Attendance, and Health Outcomes
Authors: Whited Matthew C. , Ellis Jordan M. , Freeman John Taylor , Corson Ansley T. , Greenway Stacey B. , Busch Andrew M. , Whited Amanda L. , Sears Samuel F. 
Published: May 2018

Purpose:
To explore the effects of implementation of the “Open Gym” (OG) scheduling model of cardiovascular rehabilitation administration on the rate of patient engagement and change in commonly measured clinical outcomes. Little data exist on the potential benefits of the OG model on patient completion, attendance, and clinical outcomes.

Methods:
A retrospective chart review was conducted that included the 1-y period both before and after OG model implementation. Bootstrapped regression and analysis of variance were utilized to determine (1) whether the scheduling model is associated with number of sessions attended and program completion, and (2) among those who meet their goals and thus complete the program, if the scheduling model predicts change in cardiovascular rehabilitation clinical outcomes (ie, percent weight change, 6-min walk distance, and peak metabolic equivalents during exercise) when controlling for baseline values. Follow-up analyses controlled for and explored interactions related to age, race, and sex.

Results:
In this racially diverse sample (34% nonwhite), patients under either the OG model (n = 125) or the Traditional model (n = 82) attended an equivalent number of sessions and were just as likely to complete their treatment. However, clinical outcomes favored the Traditional model, even as more patients participated in the OG model, especially racial minority patients.

Conclusions:
Although the OG model is more consistent with patient-centered care, gains in functional capacity may be diminished. Furthermore, better controlled experiments are needed to examine the effects of implementing the OG model and should include measures of possible mechanisms influencing racial differences.
Self-efficacy Predicts Success in an Exercise Training-Only Model of Pulmonary Rehabilitation for People With COPD
Authors: Blackstock Felicity C. , Webster Kate E. , McDonald Christine F. , Hill Catherine J. 
Published: May 2018

Purpose:
To determine whether people with chronic obstructive pulmonary disease (COPD) have characteristics that predict a clinically meaningful response to pulmonary rehabilitation (PR) that includes an education component compared with exercise training alone.

Methods:
Participants were classified as responders or nonresponders to 2 models of PR; exercise training and education (ET + ED, n = 113) or exercise training alone (ET, n = 85). Responders were defined as those who achieved a clinically meaningful change in 6-min walk distance (6MWD) or any of the 4 domains of the Chronic Respiratory Questionnaire (CRQ). Baseline characteristics were compared between responders and nonresponders. The associations between baseline data and change in 6MWD and CRQ following PR were examined, and a binary logistic regression analysis was conducted for each model and primary outcome.

Results:
There were no significant differences between the PR models in proportion of responders (ET + ED 92% vs ET 93%). Lower baseline CRQ scores predicted response in respective CRQ domains for fatigue, emotion, and mastery in the ET + ED group, and for dyspnea, fatigue, and mastery in the ET group. Higher baseline self-efficacy predicted 6MWD response and higher socioeconomic status predicted response in CRQ fatigue in the ET model only. There was no predictor of 6MWD response in the ET + ED group.

Conclusions:
Baseline characteristics did not reliably predict a clinically meaningful response to PR that included education. For exercise training alone, higher self-efficacy was a significant predictor for greater improvements in 6MWD, suggesting that those with higher confidence should be considered for this model.