bluuebunny/crossref_metadata_2025_split huggingface dataset:
Iterative Versus Standard Deferred Acceptance: Experimental Evidence★
Authors: Bó Inácio , Hakimov Rustamdjan 
Published: July 2019

Abstract
We test experimentally the Gale-Shapley Deferred Acceptance (DA) mechanism versus two versions of the Iterative Deferred Acceptance Mechanism (IDAM), in which students make applications one at a time. A significantly higher proportion of stable outcomes is reached under IDAM than under DA. The difference can be explained by a higher proportion of subjects following an equilibrium truthful strategy under iterative mechanisms than the dominant strategy of truthful reporting under DA. We associate the benefits of iterative mechanisms with the feedback on the outcome of the previous application they provide to students between steps.
Rare and common variant discovery in complex disease: the IBD case study
Authors: Venkataraman Guhan R , Rivas Manuel A 
Published: July 2019

Abstract
Complex diseases such as inflammatory bowel disease (IBD), which consists of ulcerative colitis and Crohn’s disease, are a significant medical burden—70 000 new cases of IBD are diagnosed in the United States annually. In this review, we examine the history of genetic variant discovery in complex disease with a focus on IBD. We cover methods that have been applied to microsatellite, common variant, targeted resequencing and whole-exome and -genome data, specifically focusing on the progression of technologies towards rare-variant discovery. The inception of these methods combined with better availability of population level variation data has led to rapid discovery of IBD-causative and/or -associated variants at over 200 loci; over time, these methods have grown exponentially in both power and ascertainment to detect rare variation. We highlight rare-variant discoveries critical to the elucidation of the pathogenesis of IBD, including those in NOD2, IL23R, CARD9, RNF186 and ADCY7. We additionally identify the major areas of rare-variant discovery that will evolve in the coming years. A better understanding of the genetic basis of IBD and other complex diseases will lead to improved diagnosis, prognosis, treatment and surveillance.
Impact of national interventions to promote responsible antibiotic use: a systematic review
Authors: Lim Jane Mingjie , Singh Shweta Rajkumar , Duong Minh Cam , Legido-Quigley Helena , Hsu Li Yang , Tam Clarence C 
Published: July 2019

Abstract

Background
Global recognition of antimicrobial resistance (AMR) as an urgent public health problem has galvanized national and international efforts. Chief among these are interventions to curb the overuse and misuse of antibiotics. However, the impact of these initiatives is not fully understood, making it difficult to assess the expected effectiveness and sustainability of further policy interventions. We conducted a systematic review to summarize existing evidence for the impact of nationally enforced interventions to reduce inappropriate antibiotic use in humans.

Methods
We searched seven databases and examined reference lists of retrieved articles. To be included, articles had to evaluate the impact of national responsible use initiatives. We excluded studies that only described policy implementations.

Results
We identified 34 articles detailing interventions in 21 high- and upper-middle-income countries. Interventions addressing inappropriate antibiotic access included antibiotic committees, clinical guidelines and prescribing restrictions. There was consistent evidence that these were effective at reducing antibiotic consumption and prescription. Interventions targeting inappropriate antibiotic demand consisted of education campaigns for healthcare professionals and the general public. Evidence for this was mixed, with several studies showing no impact on overall antibiotic consumption.

Conclusions
National-level interventions to reduce inappropriate access to antibiotics can be effective. However, evidence is limited to high- and upper-middle-income countries, and more evidence is needed on the long-term sustained impact of interventions. There should also be a simultaneous push towards standardized outcome measures to enable comparisons of interventions in different settings.
An empirical infrared transit spectrum of Earth: opacity windows and biosignatures
Authors: Macdonald Evelyn J R , Cowan Nicolas B 
Published: July 2019

Abstract
The Atmospheric Chemistry Experiment Fourier Transform Spectrometer on the SCISAT satellite has been measuring infrared (IR) transmission spectra of Earth during Solar occultations since 2004. We use these data to build an IR transit spectrum of Earth. Regions of low atmospheric opacity, known as windows, are of particular interest, as they permit observations of the planet’s lower atmosphere. Even in the absence of clouds or refraction, imperfect transmittance leads to a minimum effective thickness of hmin ≈ 4 km in the 10–12 $\mu \mathrm{m}$ opacity window at a spectral resolution of R = 103. None the less, at R = 105, the maximum transmittance at the surface is around ${70}{{{\ \rm per\ cent}}}$. In principle, one can probe the troposphere of an Earth-like planet via high-dispersion transit spectroscopy in the mid-IR; in practice aerosols and/or refraction likely make this impossible. We simulate the transit spectrum of an Earth-like planet in the TRAPPIST-1 system. We find that a long-term near-IR (NIR) campaign with the James Webb Space Telescope(JWST) could readily detect CO2, establishing the presence of an atmosphere. A mid-IR campaign or longer NIR campaign would be more challenging, but in principle could detect H2O and the biosignatures O3 and CH4.
The geometry of the gas surrounding the Central Molecular Zone: on the origin of localized molecular clouds with extreme velocity dispersions
Authors: Sormani Mattia C , Treß Robin G , Glover Simon C O , Klessen Ralf S , Barnes Ashley T , Battersby Cara D , Clark Paul C , Hatchfield H Perry , Smith Rowan J 
Published: July 2019

ABSTRACT
Observations of molecular gas near the Galactic Centre (|l| &lt; 10°, |b| &lt; 1°) reveal the presence of a distinct population of enigmatic compact clouds that are characterized by extreme velocity dispersions ($\Delta v \gt 100\, {\rm km\, s^{-1}}$). These extended velocity features are very prominent in the data cubes and dominate the kinematics of molecular gas just outside the Central Molecular Zone (CMZ). The prototypical example of such a cloud is Bania Clump 2. We show that similar features are naturally produced in simulations of gas flow in a realistic barred potential. We analyse the structure of the features obtained in the simulations and use this to interpret the observations. We find that the features arise from collisions between material that has been infalling rapidly along the dust lanes of the Milky Way bar and material that belongs to one of the following two categories: (i) material that has ‘overshot’ after falling down the dust lanes on the opposite side; (ii) material which is part of the CMZ. Both types of collisions involve gas with large differences in the line-of-sight velocities, which is what produces the observed extreme velocity dispersions. Examples of both categories can be identified in the observations. If our interpretation is correct, we are directly witnessing (a) collisions of clouds with relative speeds of $\sim 200\, {\rm km\, s^{-1}}$ and (b) the process of accretion of fresh gas onto the CMZ.
Indirect evidence of significant grain growth in young protostellar envelopes from polarized dust emission
Authors: Valdivia Valeska , Maury Anaëlle , Brauer Robert , Hennebelle Patrick , Galametz Maud , Guillet Vincent , Reissl Stefan 
Published: July 2019

ABSTRACT
How and when in the star formation sequence do dust grains start to grow into pebbles is a cornerstone question to both star and planet formation. We compute the polarized radiative transfer from a model solar-type protostellar core, using the polaris code, aligning the dust grains with the local magnetic field, following the radiative torques (RATs) theory. We test the dependency of the resulting dust polarized emission with the maximum grain size of the dust size distribution at the envelope scale, from $a_\mathrm{max}=1\,$ to $50 \,\hbox{$\mu $m}$. Our work shows that, in the framework of RAT alignment, large dust grains are required to produce polarized dust emission at levels similar to those currently observed in solar-type protostellar envelopes at millimetre wavelengths. Considering the current theoretical difficulties to align a large fraction of small ISM-like grains in the conditions typical of protostellar envelopes, our results suggest that grain growth (typically $\gt 10 \,\hbox{$\mu $m}$) might have already significantly progressed at scales 100–1000 au in the youngest objects, observed less than 105 yr after the onset of collapse. Observations of dust polarized emission might open a new avenue to explore dust pristine properties and describe, for example, the initial conditions for the formation of planetesimals.
Analyzing whole genome bisulfite sequencing data from highly divergent genotypes
Authors: Wulfridge Phillip , Langmead Ben , Feinberg Andrew P , Hansen Kasper D 
Published: July 2019

AbstractIn the study of DNA methylation, genetic variation between species, strains or individuals can result in CpG sites that are exclusive to a subset of samples, and insertions and deletions can rearrange the spatial distribution of CpGs. How to account for this variation in an analysis of the interplay between sequence variation and DNA methylation is not well understood, especially when the number of CpG differences between samples is large. Here, we use whole-genome bisulfite sequencing data on two highly divergent mouse strains to study this problem. We show that alignment to personal genomes is necessary for valid methylation quantification. We introduce a method for including strain-specific CpGs in differential analysis, and show that this increases power. We apply our method to a human normal-cancer dataset, and show this improves accuracy and power, illustrating the broad applicability of our approach. Our method uses smoothing to impute methylation levels at strain-specific sites, thereby allowing strain-specific CpGs to contribute to the analysis, while accounting for differences in the spatial occurrences of CpGs. Our results have implications for joint analysis of genetic variation and DNA methylation using bisulfite-converted DNA, and unlocks the use of personal genomes for addressing this question.
Noninvasive Localization of Language Cortex in an Awake 4-Year-Old Child with Rasmussen Encephalitis: A Case Report
Authors: Narayana Shalini , Embury Luke M , Shah Namrata , Weatherspoon Sarah , Choudhri Asim F , Boop Frederick A 
Published: July 2019

Abstract

BACKGROUND AND IMPORTANCE
Presurgical mapping of eloquent cortex in young patients undergoing neurosurgery is critical for timely intervention, surgical planning, and minimizing postoperative deficits. However, invasive direct cortical stimulation has limited success in young children and noninvasive modalities, such as magnetoencephalography and functional MRI, require sedation, often precluding localization of critical language cortices. Transcranial magnetic stimulation (TMS), a noninvasive brain stimulation technique, is well suited to evaluate language areas in young children because it does not require the patient to remain still during mapping.

CLINICAL PRESENTATION
A 4-yr and 11-mo-old female patient diagnosed with epilepsia partialis continua of the right arm and face and right-sided weakness was evaluated at our institution. MRI findings and clinical examination led to the diagnosis of Rasmussen encephalitis involving left frontal lobe and insula. Language cortices were successfully identified in both hemispheres using TMS. The TMS findings aided in discussing with the family the risks of postsurgical deficits of left functional hemispherectomy, the definitive treatment for Rasmussen encephalitis. Postoperatively, the patient had intact speech and was seizure free.

CONCLUSION
We illustrate the feasibility and utility of TMS as a noninvasive functional mapping tool in this young child. The preoperative demonstration of bilateral language organization indicated a greater likelihood of preserved language functions postsurgery. We demonstrate that TMS is a safe and noninvasive tool to map language cortices in young children with serious epilepsy syndromes.
Relationships matter: How clinicians can support positive parenting in the early years
Authors: Williams Robin C , Biscaro Anne , Clinton Jean 
Published: July 2019

AbstractA secure attachment relationship with at least one healthy adult is essential for a child to develop optimal coping abilities. Primary care providers like paediatricians and family physicians can help by supporting parents in practice settings. Every clinician encounter is an opportunity to ask parents about children’s relationships and their behaviour, daily routines, and overall family function. This statement, which focuses on children aged 0 to 6 years, describes basic principles in support of positive parenting and recommends in-office practices to promote secure parent–child relationships, engage families and build trust with parents. Crying, sleep, and difficult behaviours are described as opportunities for clinicians to provide anticipatory, responsive guidance to parents.
VARIATION SIMULATION OF RADON CONCENTRATION IN THE TISSUES AND ORGANS OF THE BODY BY AN ELECTRICAL CIRCUIT
Authors: Pirmoradi Milad , Negarestani Ali , Baghizadeh Amin 
Published: July 2019

Abstract
In this study, a new model based on electric circuit theory has been introduced to simulate the dynamics of radioactive chemically inert gases in the human body. For this manner, it is assumed that inert gas is transported through the body to various organs via the blood stream. In this simulation, a voltage source is equivalent to gas generation in the atmosphere, the conductivity is equivalent to the cardiac output of the organ, the capacitor capacitance is equivalent to the volume of blood or tissue and voltage across a capacitor is equivalent to the gas concentration in air or blood or a tissue. This simulation can be used to study the dynamics of any inert gas whose partition coefficients are known. We use this simulation to study the dynamics of radon in human body. The physiologically based pharmacokinetic (PBPK) model that describes the fate of radon in systemic tissue has been used for this simulation. Using this simulation, the effective dose equivalent resulting from inhalation of radon has been estimated. The calculated values agree with the previously reported value. Also, using the model, it has been shown that after inhalation of radon gas, absorbed dose has been decreased in different tissues by increasing the inhalation rate without radon. So that, by doubling the inhalation rate and the rate of cardiac output, the value of the absorbed dose has been decreased 11.88% in the adipose tissue, 25.49% in the red marrow tissue and 20.3% in the liver organ.
Low-Density EEG for Neural Activity Reconstruction Using Multivariate Empirical Mode Decomposition
Authors: Soler Andrés Felipe , Muñoz-Gutiérrez Pablo A. , Bueno-López Maximiliano , Giraldo Eduardo , Molinas Marta 
Published: July 2019

AbstractSeveral approaches can be used for estimating neural activity. The main differences between them are in the apriori information used and their sensibility to high noise levels. Empirical Mode Decomposition (EMD) has been recently applied to Electroencephalography EEG-based neural activity reconstruction to provide apriori time-frequency information to improve the neural activity estimation. EMD has the specific ability to identify independent oscillatory modes in non-stationary signals with multiple oscillatory components. The various attempts to use EMD in EEG analysis, however, did not provide yet the best reconstructions due to the intrinsic mode mixing problem of EMD. Some previous works have used a single-channel analysis and in other cases, multiple-channel have been used for other applications. In this paper, we present a study about multiple-channel analysis using Multivariate Empirical Mode Decomposition (MEMD) as a method to attenuate the mode mixing problem and to provide apriori useful time-frequency information to the reconstruction of neuronal activity using several low-density EEG electrode montages. The methods were evaluated over real and synthetic EEG data, in which the reconstructions were performed using multiple sparse priors (MSP) method with several electrode numbers of 32, 16, and 8, and the source reconstruction quality was measured using the Wasserstein Metric. Comparing the solutions when no pre-processing was made and when MEMD was applied, the source reconstructions were improved using MEMD as apriori information in the low-density montage of 8 and 16 electrodes. The mean source reconstruction error on a real EEG dataset was reduced a 59.42% and 66.04% for the 8 and 16 electrodes montages respectively, and on a simulated EEG with three active sources, the mean error was reduced an 87.31% and 31.45% for the same electrodes montages.
Determination of the auxiliary anode position via finite element method in impressed current cathodic protection
Authors: Liu Yingwei , Zhang Zhongwu , Zhang Yang , Zhang Jianneng 
Published: July 2019

Purpose
It is a challenge in the design to determine the feasible anode position and the supply current when the hull is protected by the impressed current cathodic protection method. It is difficult to obtain these parameters through traditional experimental methods due to the huge hull surface area and geometric complexity. This study aims to solve the problem by finite element method.

Design/methodology/approach
First, a great number of experiments need to be conducted; second, experiments are empirical; finally, there exist measurement errors, etc. All these factors make the experimental results less reliable. The application of the finite element method, combined with other technologies, is expected to overcome these deficiencies. In this paper, the combined Matlab and Comsol method was used to calculate various anode positions and corresponding protection areas with a series of input current conditions. The calculation is implemented via the script in Matlab.

Findings
As a result, the best design can be obtained. The results show that the method provided in this paper can replace the experiment to a certain extent, save human and material resources and reduce the design time. The method also can be applied to other similar fields, having a good universality.

Originality/value
This optimization method can be extended to other areas of relevant production and research, having a good universality.
Model order reducibility of nonlinear electro-quasistatic problems
Authors: Kasolis Fotios , Clemens Markus 
Published: July 2019

Purpose
This paper aims to develop an automated domain decomposition strategy that is based on the presence of nonlinear field grading material, in the context of model order reduction for transient strongly nonlinear electro-quasistatic (EQS) field problems.

Design/methodology/approach
The paper provides convincing empirical insights to support the proposed domain decomposition algorithm, a numerical investigation of the performance of the algorithm for different snapshots and model order reduction experiments.

Findings
The proposed method successfully decomposes the computational domain, while the resulting reduced models are highly accurate. Further, the algorithm is computationally efficient and robust, while it can be embedded in black-box model reduction implementations.

Originality/value
This paper fulfills the demand to effectively perform model order reduction for transient strongly nonlinear EQS field problems.
Enactments of a “holistic approach” in two Danish welfare institutions accommodating young adults with offending behavior and drug use experiences
Authors: Herold Maria Dich , Rand Cecilia , Frank Vibeke Asmussen 
Published: July 2019

Purpose
The purpose of this paper is to discuss how a “holistic approach” is enacted in two interventions accommodating the same target group, young adults with offending behaviour and drug use experiences, but offered in very different contexts, the Prison Service and the community. The aim is to show how enactments of a “holistic approach”, although similar on paper, differ in welfare institutional practices due especially to organisational and structural conditions.

Design/methodology/approach
The paper is based on qualitative semi-structured interviews and written material from and about the two interventions.

Findings
Different enactments of a “holistic approach”, due to organisational and structural conditions of the interventions, construct different possibilities for institutional identities. These insights could be useful to take into consideration when discussing prevention initiatives (in a broad sense) for young people with complex problems, including co-occurring offending behaviour and drug use experience.

Originality/value
Research with a focus on citizens with complex problems who do not comply with OR conform to standard welfare institutions are limited. The authors contribute to this literature by focussing on young adults with offending behaviour and drug experiences.
Race and workplace discrimination
Authors: Daniels Shanna , Thornton LaDonna M. 
Published: July 2019

PurposeDrawing upon theories of modern discrimination, the present study focuses on cyber incivility and interpersonal incivility as mechanisms through which race leads to perceived discrimination. Participants included 408 full-time working adults who responded to an online survey. The results indicate that Non-White employees experience subtle forms of discrimination through the use of e-mail, which accentuate the need for organizations to eradicate workplace mistreatment so that their employees can avoid the adverse outcomes associated with experiencing cyber incivility. The purpose of this paper is to extend the understanding of selective incivility and concludes with directions for future research and practical implications.Design/methodology/approachParticipants included 408 full-time working adults who responded to the survey online.FindingsThe results indicate that race was indirectly associated with discrimination through cyber incivility. The results indicate that Non-White employees experience subtle forms of discrimination through the use of technology and cyber space which accentuate the need for organizations to eradicate workplace incivility so that their employees can evade the adverse outcomes associated with experiencing incivility at work.Research limitations/implicationsThis study extends the understanding of selective incivility and concludes with directions for future research and practical implications.Originality/valueThis paper is the first to explore the relationship between race, cyber incivility and discrimination.