bluuebunny/crossref_metadata_2025_split huggingface dataset:
rs11670527 Upstream of ZNF264 Associated with Body Mass Index in the Coriell Personalized Medicine Collaborative
Authors: Kusic Dara M , Roberts Wendy N , Jarvis Joseph P , Zhang Pan , Scheinfeldt Laura B , Rajula Kaveri D , Brenner Ruth , Dempsey Michael P , Zajic Stefan C 
Published: September 2019

Abstract
Introduction: the effects of obesity on health are a concern for the military as they affect the fitness to serve of active service members, increase costs to the Military Health System, and reduce quality of life for veterans and beneficiaries. Although obesity can be influenced by behavioral and environmental factors, it has also been shown to be associated with genetic risk factors that are not fully understood. Materials and Methods: we performed a genome-wide association study of 5,251 participants in the Coriell Personalized Medicine Collaborative, which includes 2,111 Air Force participants. We applied a generalized linear model, using principal component analysis to account for population structure, and analyzed single-variant associations with body mass index (BMI) as a continuous variable, using a Bonferroni-corrected P-value threshold to account for multiplicity. Results: we identified one genome-wide significant locus, rs11670527, upstream of the ZNF264 gene on chromosome 19, associated with BMI. Conclusions: the finding of an association between rs11670527 and BMI adds to the growing body of literature characterizing the complex genetics of obesity. These efforts may eventually inform personalized interventions aimed at achieving and maintaining healthy weight.
Replicated Umbilical Cord Blood DNA Methylation Loci Associated with Gestational Age at Birth
Authors: York Timothy P. , Jackson-Cook Colleen , Moyer Sara , Roberson-Nay Roxann , Murphy Susan K. , Fuemmeler Bernard F. , Latendresse Shawn J. , Lapato Dana M. , Wolen Aaron R. , Do Elizabeth K. , Hoyo Catherine , Strauss Jerome F. 
Published: September 2019

ABSTRACTBackgroundDNA methylation is highly sensitive to in utero perturbations and has an established role in both embryonic development and regulation of gene expression. The fetal genetic component has been previously shown to contribute significantly to the timing of birth, yet little is known about the identity and behavior of individual genes.ObjectivesThe aim of this study was to test the extent genome-wide DNA methylation levels in umbilical cord blood were associated with gestational age at birth (GA). Findings were validated in an independent sample and evidence for the regulation of gene expression was evaluated for cis gene relationships in matched specimens.ResultsGenome-wide DNA methylation, measured by the Illumina Infinium Human Methylation 450K BeadChip, was associated with GA for 2,372 CpG probes (5% false discovery rate) in both the Pregnancy, Race, Environment, Genes (PREG – Virginia Commonwealth University) and Newborn Epigenetic Study (NEST – Duke University) cohorts. Significant probes mapped to 1,640 characterized genes and an association with nearby gene expression measures obtained by the Affymetrix HG-133A microarray was found for 11 genes. Differentially methylated positions were enriched for actively transcribed and enhancer chromatin states, were predominately located outside of CpG islands, and mapped to genes enriched for inflammation and innate immunity ontologies. In both PREG and NEST, the first principal component derived from these probes explained approximately one-half (58.1% and 47.8%, respectively) of the variation in GA. This assessment provides a strong evidence to support the importance of DNAm change throughout the gestational time period.ConclusionsThese results converge on support for the role of variation in DNAm measures as an important genetic regulatory mechanism contributing to inter-individual differences in gestational age at birth. In particular, the pathways described are consistent with the well-known hypothesis of pathogen detection and response by the immune system to elicit premature labor as a consequence of unscheduled inflammation.
Homeostatic plasticity rules that compensate for cell size are susceptible to channel deletion
Authors: Gorur-Shandilya Srinivas , Marder Eve , O’Leary Timothy 
Published: September 2019

AbstractNeurons can increase in size dramatically during growth. In many species neurons must preserve their intrinsic dynamics and physiological function across several length scales. For example, neurons in crustacean central pattern generators generate similar activity patterns despite multiple-fold increases in their size and changes in morphology. This scale invariance hints at regulation mechanisms that compensate for size changes by somehow altering membrane currents. Using conductance-based neuron models, we asked whether simple activity-dependent feedback can maintain intrinsic voltage dynamics in a neuron as its size is varied. Despite relying only on a single sensor that measures time-averaged intracellular calcium as a proxy for activity, we found that this regulation mechanism could regulate conductance densities of ion channels, and was robust to changes in the size of the neuron. By mapping changes in cell size onto perturbations in the space of conductance densities of all channels, we show how robustness to size change coexists with sensitivity to perturbations that alter the ratios of maximum conductances of different ion channel types. Our findings suggest that biological regulation that is optimized for coping with expected perturbations such as size changes will be vulnerable to other kinds of perturbations such as channel deletions.
The corrosion behavior of chromated AA2024 aluminum alloy in 3.5% NaCl solution
Authors: Zhou Yong , Zhang Pei , Xiong Jinping , Yan Fuan 
Published: September 2019

PurposeA chromate conversion coating was prepared on the surface of bare AA2024 aluminum alloy by direct immersion in the chromating treatment bath, and the corrosion behavior of chromated AA2024 aluminum alloy in 3.5 per cent NaCl solution was studied by electrochemical measurement and microstructural observation.Design/methodology/approachAccording to the polarization curve test and the scanning electron microscope observation, the corrosion evolution of chromated AA2024 in 3.5 per cent NaCl solution was divided into the following three stages: coating failure, pitting corrosion and intergranular corrosion (IGC).FindingsIn the first stage, the chromate coating degraded gradually due to the combined action of chloride anions and water molecules, resulting in the complete exposure of AA2024 substrate to 3.5 per cent NaCl solution. Subsequently, in the second stage, chloride anions adsorbed at the sites of θ phase (Al2Cu) and S phase (Al2CuMg) on the AA2024 surface preferentially, and some corrosion pits initiated at the above two sites and propagated towards the deep of crystal grains. However, the propagation of a pit terminated when the pit front arrived at the adjacent grain boundary, where the initiation of IGC occurred.Originality/valueFinally, in the third stage, the corrosion proceeded along the continuous grain boundary net and penetrated the internal of AA2024 substrate, resulting in the propagation of IGC. The related corrosion mechanisms for the bare and the chromated AA2024 were also discussed.
The ecosystem of drivers for electronic procurement adoption for construction project procurement
Authors: Yevu Sitsofe Kwame , Yu Ann Tit Wan 
Published: September 2019

Purpose
The purpose of this paper is to present a review of research developments on the ecosystem of driving forces for electronic procurement (e-procurement) on project procurement and to propose directions for future research for an effective adoption and sustained usage.

Design/methodology/approach
A systematic literature review was conducted in three phases to identify and examine literature. A total of 68 papers were retrieved and were thoroughly reviewed to identify the drivers for e-procurement.

Findings
A total of 61 drivers were identified and subsequently developed into a categorization framework for synthesized understanding which reveals existing interrelationships. Although literature has consensus on some selected drivers, few studies have identified drivers relating to sustainability. Gaps were identified from the existing literature and directions for future research were proposed.

Research limitations/implications
Since this is a literature review, future research could conduct further investigations focusing on the research gaps identified. The framework developed presents a basis for further research to explore the drivers in various socio-economic environments.

Practical implications
This study provides valuable insights for improving the understanding of practitioners on the complex network of drivers for e-procurement. These findings stimulate discussions on benefits required for assessment in e-procurement adoption by practitioners.

Originality/value
This study provides the first comprehensive review of the drivers for e-procurement adoption in the construction industry, which was lacking in the existing body of knowledge.
Ways to improve the project management efficiency in a centralized public procurement system
Authors: Wang Yang , Liu Jing , Zuo Jian , Rameezdeen Raufdeen 
Published: September 2019

Purpose
The purpose of this paper is to investigate driving factors that improve the project management efficiency (PME) in centralized public procurement systems.

Design/methodology/approach
Employees in four public-sector organizations in China were surveyed. The structural equation modeling was employed to examine the relationship amongst those variables.

Findings
Organizational culture (OC) is an effective method to improve PME, and employee quality is the most critical factor of OC in this system. Job satisfaction (JS) is another significant contributor to PME and satisfaction with fairness of salary in this system being the key factor of JS. Job analysis (JA) has indirect influence on PME through JS and OC, whereas the job structure in this system is the most critical factor for JA.

Practical implications
An operational way to improve PME is to implement it from the perspectives of employee, organization and technique. At the organizational level, it is imperative to strengthen the OC by a well-structured recruitment system and to improve PME via well-design training. At the person level, both financial (i.e. income and welfare) and career incentives (i.e. promotion opportunities and a sense of belonging) are proposed to achieve employees’ JS to improve PME. At the technique level, JA approach (i.e. job rotation) is recommended to enlarge the positive influence of OC and JS on PME. These can not only ensure the management professionalism in a centralized public procurement system but can also motivate employees and maximize PME.

Originality/value
PME in a centralized public procurement system will be improved by addressing these key factors and their interrelationships. This provides detailed pathways for the centralized public procurement system to achieve better PME via optimal OC and JS and reasonable JA in China. In addition, the institutional and administrative traditions may vary significantly across cities, regions and countries. Therefore, such contextual differences should be taken into consideration for the improvement of PME in a centralized public procurement system.
Modeling of macrosegregation benchmarks using a stabilized finite element algorithm based on a semi-implicit pressure correction scheme
Authors: Chen Kangxin , Shen Houfa 
Published: September 2019

Purpose
The purpose of this paper is to simulate two macrosegregation benchmarks with a newly developed stabilized finite element algorithm based on a semi-implicit pressure correction scheme.

Design/methodology/approach
A streamline-upwind/Petrov–Galerkin (SUPG) stabilized finite element algorithm is developed for the coupled conservation equations of mass, momentum, energy and species. A semi-implicit pressure correction method combined with SUPG stabilization technique is proposed to solve the convection flow during solidification. An analytically derived enthalpy method is adopted to solve the energy conservation equation. The nonlinearities of the energy and species equations are tackled by Newton–Raphson method. Two macrosegregation benchmarks considering the solidification of an Al-4.5 per cent Cu alloy and a Sn-10 per cent Pb alloy are simulated.

Findings
A very good agreement is achieved by comparison with the classical finite volume method and a novel meshless method for the Al-4.5 per cent Cu alloy solidification benchmark. Moreover, a unique reference numerical solution has been obtained. Besides, it is demonstrated that the stabilized finite element algorithm can capture the flow instability and channel segregation during solidification of the Sn-10 per cent Pb alloy.

Originality/value
A semi-implicit pressure correction method combined with SUPG stabilization technique is adopted to develop robust stabilized finite element algorithm for the macrosegregation model. A new enthalpy formulation for heat transfer problems with phase change is derived analytically.
An overview of faba bean: utilisation of husks in natural dyeing
Authors: Erdem Ismal Özlenen , Yıldırım Leyla 
Published: September 2019

Purpose
The purpose of this paper is to reveal the potential use of faba bean husk as natural dye, to create a color gamut and to observe the effect of different mordants. Dyeing properties of polyamide/elastane fabric using faba been husk were investigated. The effect of alum [KAl(SO4)2], iron II sulfate Fe(SO4)7H2O, tin II chloride (SnCI22H2O), copper II sulfate (CuSO4), citric acid (C6H8O7), tartaric acid (C4H6O6), oxalic acid (H2C2O4), ammonium sulfate [(NH4)2SO4], sodium acetate (C2H3NaO2), combination of alum-iron, iron-tin and alum-tin were evaluated in terms of color yield, color coordinates and wash fastness.

Design/methodology/approach
Mainly, dyeings were conducted in accordance with a simultaneous mordanting method. However, pre-mordanted dyeings were also implemented with selected concentration (0.8 g/L) of metallic mordants to enrich color gamut. Control sample (without mordant) was used as a reference for examining the effect of different mordants. Dyed samples were compared mutually in the light of visual evaluation and color measurements and alternatives to metallic mordants were also assessed.

Findings
Significant differences occurred in color coordinates of dyed samples. The biggest color difference and completely different color shades were achieved with tin II chloride. The type of acid did not create visible color differences. As alternatives to metallic mordants; all of them may be used instead of alum (0.8 g/L). Tartaric acid and oxalic acid, instead of iron II sulfate (0.2 g/L), and ammonium sulfate (0.2 g/L) and sodium acetate (0.8 g/L), instead of alum (0.8 g/L), can be used. Sodium acetate cannot be replaced with iron. A combination of alum-iron and iron-tin can be the alternative to 0.2 and 0.8 g/L copper, respectively. All the samples provided good wash fastness (4/5) values.

Originality/value
Valorization of industrial, agricultural and domestic wastes as novel natural dye sources is an ecological and sustainable approach. Moreover, the use of man-made fibers in natural dyeing is an issue that needs to be developed and expanded. Few literatures have been found concerning the use of husks of faba bean as a natural colorant. In this initial study, husks of faba been as a vegetable waste were utilized in natural dyeing of polyamide/elastane fabric. It is suggested that this waste can be turned into an economic value through its valorization in natural dyeing.
Comparing factors that influence learning management systems use on computers and on mobile
Authors: Hu Xiao , Lai Chun 
Published: September 2019

PurposeLearning management systems (LMSs) have been embraced for their potential to create a ubiquitous learning that is free from time and space constraints. Mobile devices afford enhanced mobility that enables flexible learning with LMSs. Thus, understanding students’ use of mobile devices to interact with LMSs and the influencing factors is essential. This paper aims to examine the factors that influenced students’ behavioural intention in using Web-based LMSs via mobile phones and compared the factors with those that affect students’ general acceptance of Web-based LMSs.Design/methodology/approachThis study surveyed 356 university students and interviewed 17 students on the various factors that might affect their LMS adoption. Structural equation modelling was used to analyse the survey data.FindingsThis study identified that perceived usefulness, perceived ease of use, social influence and facilitating conditions were significant determinants of students’ usage intention in both contexts. However, social factors exerted greater influence on students’ behavioural intentions of mobile access than the attitudinal factors. The results also pinpointed some sociocultural and tempo-spatial factors that might have minimized the influence of perceived usefulness in the mobile context.Originality/valueThe study calls for special attention to the potential influences of sociocultural norms and tempo-spatial circumstances of mobile use in shaping the nature of learners’ voluntary mobile use of LMSs.
Implementation of technology innovation in MSMEs in India
Authors: Singh Davinder 
Published: September 2019

Purpose
In the present age of globalization, micro, small and medium enterprises (MSMEs) are consistently causative to productivity growth and, consequently, competitiveness and aggregate economic growth by providing the training opportunities, basic services and are believed to be especially effective job creators and enjoy the reputation of being sources of income. But technological progressions have increased greatly, the competition impelled by the globalization of the world economies and even MSMEs are no more protected to the challenges that the globalization brings about. It is a remarkable, and in certain instances, a worrying situation because MSMEs play an important role in most economies, including in India, in that they comprise the largest business block and offer the bulk of employment. The purpose of this paper is to assess the status of problems faced by MSMEs and study the technology innovation implementation (TII) dimensions in the selected small firms in the Northern region in India.

Design/methodology/approach
The methodology used for this study is a combination of literature review, expert opinion, comparative case study and a flexible systems methodology, SWOT and situation-actor-process-learning-action-performance analysis. Longitudinal studies of technology innovation at the two small firms have been conducted, and the case analysis and synthesis have been developed based on important inputs and insights shared by key personnel in the select firms.

Findings
The study finds that two different firms have faced similar kind of challenges in this competitive environment. Also the findings suggest that an effective TII can contribute to enhance manufacturing performance in MSMEs in India.

Originality/value
The research presents a better understanding of the problems that are preventing the successful implementation of technology innovation in small firms. Further, the two cases provide valuable insights into TII dimensions in two firms and highlight the methodology to be adopted by the companies toward their manufacturing performance enhancement.
eDNA surveys to detect species at very low densities: A case study of European carp eradication in Tasmania, Australia
Authors: Furlan Elise M. , Gleeson Dianne , Wisniewski Chris , Yick Jonah , Duncan Richard P. 
Published: September 2019

Abstract

Eradications of invasive species are usually expensive and difficult to conduct. Knowing when to declare an eradication successful requires distinguishing between failed detection of the target species due to imperfect sensitivity of the detection method and true species absence. This is difficult because the sensitivities of many detection methods are unknown.

Environmental DNA (eDNA) methods can be used to detect species by analysing DNA present in environmental samples. eDNA has been promoted as a particularly sensitive and cost‐effective way to detect species at low densities and, importantly, the sensitivity of eDNA surveys can be quantified. Nevertheless, the effort and costs involved in detecting species at extremely low densities, such as required during eradication, have not been previously calculated.

We evaluated the sensitivity of eDNA surveys in detecting the invasive European carp, Cyprinus carpio, in two lakes in Tasmania, Australia, one in which carp have been eradicated and a second in which carp are currently being eradicated. We determined the sampling effort and associated cost required to detect the species at very low density in these lakes.

While our eDNA survey detected the current low density carp population present in Lake Sorell, we show that an exponential increase in sampling effort and associated cost will be required to confidently detect the species as the population declines. Similarly, while our eDNA survey corroborated the species absence from Lake Crescent, our detection confidence was low. We quantify the survey effort and financial investment required to confidently establish eradication success in Lake Crescent.

Synthesis and applications. Estimating the environmental DNA (eDNA) survey effort and cost required to detect species at a given density will enable practitioners to make informed decisions on the feasibility of implementing such surveys. Quantifying the sensitivity of eDNA surveys will also inform the confidence practitioners should place in eDNA detection results to ensure appropriate management actions are implemented and provide a suitable stopping point at which to confidently declare eradication success.
Recent Ogallala Aquifer Region Drought Conditions as Observed by Terrestrial Water Storage Anomalies from GRACE
Authors: Zhang Yongjun , Lin Xiaomao , Gowda Prasanna , Brown David , Zambreski Zachary , Kutikoff Seth 
Published: September 2019

AbstractRecent severe drought events have occurred over the Ogallala Aquifer region (OAR) during the period 2011–2015, creating significant impacts on water resources and their use in regional environmental and economic systems. The changes in terrestrial water storage (TWS), as indicated by the Gravity Recovery and Climate Experiment (GRACE), reveals a detailed picture of the temporal and spatial evolution of drought events. The observations by GRACE indicate the worst drought conditions occurred in September 2012, with an average TWS deficit of ~8 cm in the northern OAR and ~11 cm in the southern OAR, consistent with precipitation data from the Global Precipitation Climatology Project. Comparing changes in TWS with precipitation shows the TWS changes can be predominantly attributable to variations in precipitation. Power spectrum and squared wavelet coherence analysis indicate a significant correlation between TWS change and the El Nino‐Southern Oscillation, and the influence of equatorial Pacific sea surface temperatures on TWS change is much stronger in the southern OAR than the northern OAR. The results of this study illustrate the value of GRACE in not just the diagnosis of significant drought events, but also in possibly improving the predictive power of remote signals that are impacted by nonregional climatic events (El Nino), ultimately leading to improved water resource management applications on a regional scale. Editor’s note: This paper is part of the featured series on Optimizing Ogallala Aquifer Water Use to Sustain Food Systems. See the February 2019 issue for the introduction and background to the series.