bluuebunny/crossref_metadata_2025_split huggingface dataset:
Institutional and artistic changes in Estonian performing arts with a case study of Vaba Lava / Open Space
Authors: Pesti Madli , Reidolv Kristiina 
Published: November 2018

The article gives an insight into the theatre system of Estonia, the development of the system in the turmoil of history and the current situation in the 21st century.
The first part of the article looks back at the period of 30 years: what happened with the Estonian theatre system when it moved from the Soviet occupation period into the Republic of Estonia. We show the developments in the funding system of theatres during the big changes in the socio-economic environment. We give an insight into how theatres are funded nowadays: how the funding of public and private theatres is connected with the quantitative (the number of premieres, performances and visits to the theatre) and qualitative (nominations, awards and artistic tendencies) results.
The second part of the article is a case study. We introduce a new type of performing arts organization in the Nordic and Baltic countries – Vaba Lava (Open Space) in Tallinn, which is funded as a PPP (public private partnership) in cooperation between the private and the public sector. Vaba Lava offers an open platform to all private theatres and companies offering them both a stage for performing as well as support services. The core of the Vaba Lava programme is its International Curated Programme. Performances of the programme are selected by a team of curators, who announce an International Open Call. The projects are selected from the applications submitted to the competition. We show how this kind of theatre is adapting to the funding system and what kind of performance strategies and working practices have been developed. We analyse what are the main artistic ideas of the international programme that also gives voice to underprivileged people talking about socially relevant themes.
The general research questions of the article are: how Estonian theatre has developed during the last decades and how it is adapting to the prevailing financial system? What kind of performance strategies and working practices have been developed and how do the economic conditions affect the artistic outcome?
The impact of torture on mental health in the narratives of two torture survivors
Authors: De la Rie Simone M. , Bos Jannetta , Knipscheer Jeroen , Boelen Paul A 
Published: November 2018

Introduction: Torture survivors risk developing Posttraumatic Stress Disorder (PTSD) as well as other mental health problems. This clinical case study describes the impact of torture on two survivors who were treated for their PTSD with Narrative Exposure Therapy.
Methods: The reports of the narratives of two torture survivors were qualitatively analyzed. It was hypothesized that torture yields overaccommodating cognitions, as well as mental defeat, which in turn, are related to severity of psychological complaints.
Results: Both patients have experienced an accumulation of traumatic events. The psychological and physical torture they experienced lead to increased anticipation anxiety, loss of control and feelings of hopelessness, as well as overaccommodating cognitions regarding self and others.
Conclusions: Cognitions, culture and beliefs, as well as issues of confidence and a more long-term perspective affect therapeutic work. Building trust, pacing the therapeutic process, and applying tailor-made interventions that focus on cognitions regarding self-esteem, trust in relationships, as well as safety and control are warranted.
Satisfaction of trauma-affected refugees treated with antidepressants and Cognitive Behavioural Therapy
Authors: Buhmann Caecilie Böck , Carlsson Jessica , Mortensen Erik Lykke 
Published: November 2018

Purpose: This study seeks to evaluate the satisfaction of trauma-affected refugees after treatment with antidepressants, psycho-education and flexible Cognitive Behavioral Therapy (CBT) including trauma exposure.
Material and methods: A treatment satisfaction questionnaire was completed by patients at the end of a randomised controlled trial (RCT) comparing treatment with CBT and antidepressants. A patient satisfaction score was developed based on the questionnaire, and predictors of satisfaction were analysed in regression models. Telephone interviews were conducted with patients dropping out of treatment before the end of the trial.
Results: In total, 193 trauma-affected refugees with PTSD were included in the study. Patients were overall satisfied with flexible CBT including exposure treatment in cases where this was part of the treatment. There was no statistically significant association between treatment outcome and satisfaction and satisfaction and treatment efficacy were independent of each other. The results showed that bi-cultural patients who had lived in Denmark for more than a decade were satisfied with the treatment based on a western psychotherapy model.
Discussion: Treatment with selective serotonin reuptake inhibitor and flexible CBT, including trauma exposure, is acceptable for trauma-affected refugees. More studies are needed to evaluate patient satisfaction with western psychotherapy models in refugee patients who have recently arrived and to compare satisfaction with alternative treatment models.
It never happened to me, so I don’t know if there are procedures”: identification and case management of torture survivors in the reception and public health system of Rome, Italy
Authors: Spissu Caterina , De Maio Gianfranco , Van den Bergh Rafael , Ali Engy , Venables Emilie , Burtscher Doris , Ponthieu Aurelie , Ronchetti Mario , Mostarda Narciso , Zamatto Federica 
Published: November 2018

Background: Access and linkage to care for migrant torture survivors is contingent on their identification and appropriate referral. However, appropriate tools for identification of survivors are not readily available, and the (staff of) reception systems of host countries may not always be equipped for this task. This study explores practices in the identification and case management of torture survivors in the reception structures and in the public health sector in Rome, Italy.
Method: Data were analysed manually and codes and themes generated.
Results: A non-homogeneous level of awareness and experience with torture survivors was observed, together with a general lack of knowledge on national and internal procedures for correct identification of torture survivors. Identification and case management of torture survivors was mainly carried out by non-trained staff. Participants expressed the need for training to gain experience in the identification and management of torture survivors’ cases, as well support and increased resources at both the reception and public health system levels.
Conclusions: The crucial process of identification and prise en charge of survivors of torture among migrant and refugee populations is relegated to nontrained and inexperienced professionals at different levels of the reception system and public health care sector, which may carry a risk of non-identification andpossible harm to survivors. Additional resources and structured interventions are urgently needed, in the form of developing procedures, training, and adapted multidisciplinary services.
De l’informe de Bataille à l’excommunication de Galloway : perspectives intermédiales sur le théâtre du Long XXe siècle
Authors: Larrue Jean-Marc 
Published: November 2018

L’idée d’informe que développe Georges Bataille dans les années 1920, en marge du mouvement surréaliste et en lien avec lui, relève de ce qu’on pourrait assimiler à une poétique de l’inexprimé. Il n’existe pas d’illustrations satisfaisantes ni de définition claire de l’informe chez Bataille, mais les questions qu’il soulève sont fondamentales et touchent au coeur même des processus de création. L’une des hypothèses que défend « De l’informe de Bataille à l’excommunication de Galloway : perspectives intermédiales sur le théâtre du Long XXe siècle » est que cette quête de l’informe pourrait être un des facteurs qui provoquent les dynamiques de remédiation décrites par Bolter et Grusin (1999). Toutefois, les ultimes avancées en intermédialité et, plus largement, dans le champ de la pensée de la médiation, ouvrent d’autres perspectives, qui transcendent la logique communicationnelle traditionnelle. L’informe relèverait donc plutôt de ce que Galloway (2013) appelle l’excommunication.
Tuer l’oeuvre dans l’oeuf : dés-écritures du plateau
Authors: Ouellet Anne-Marie 
Published: November 2018

Cet article propose d’observer comment certains créateurs de la scène contemporaine travaillent à maintenir leur oeuvre dans un informe, un « à venir » (Blanchot, 1959), qui ouvre un champ illimité de constructions fictionnelles. Selon l’hypothèse défendue, par le recours au procédé de minoration (Deleuze, 1979), qui consiste à affaiblir ou à retirer volontairement un ou des éléments constituants de l’oeuvre, les trois oeuvres étudiées appelleraient une participation plus active du spectateur dans sa réception. Blind Cinema (2015), de Britt Hatzius, s’appuie sur un principe de masquage. The Pyre (2013), de Gisèle Vienne, retire le texte de la représentation pour enfouir la fiction dans les corps des interprètes. La chambre sonore de la maladie de la mort (2018), de L’eau du bain, parie sur une écriture scénique au conditionnel qui s’interdit d’affirmer un récit.
Признаки избыточности в падежной системе русского языка: трудности с усвоением окончаний и синкретизм падежных форм
Authors: Viimaranta Johanna , Kanerva Oksana , Timofeeva Alina , Olsson Gustaf 
Published: November 2018

В данной статье мы анализируем функцию падежных окончаний в русском языке с помощью двух лингвистических экспериментов. Целью первого является выяснить, насколько хорошо русскоязычные, проживающие в Финляндии (как носители языка, так и те, для кого русский язык не является родным, но владеющие им на высоком уровне), понимают, к какому падежу или числу принадлежит слово в том случае, если правильная форма является омофоном с хотя бы одной другой грамматической формой. Второй эксперимент призван ответить на вопрос, нужны ли падежные окончания носителям русского языка, чтобы определить синтаксические связи между словами. Полагаясь на результаты первого эксперимента, мы утверждаем, что категория числа в восприятии носителей языка более развита, чем падеж; а результаты второго эксперимента предполагают, что в случае падежного синкретизма, другие факторы влияют на определение синтаксических связей между словами внутри предложения. In this article we analyze the function of case endings in the Russian language by means of two linguistic experiments. In the first one we aim to discover how well Russian speakers living in Finland (native speakers and non-natives highly proficient in the language) understand which case or number a word belongs to when the correct word form is homophonous with at least one other form. The second experiment seeks to answer the question of whether native Russian speakers need case endings to be able to distinguish syntactic connections between words. The results of the first experiment show that the category of number is more developed than the category of case in the perception of the native speakers, while the second experiment suggests that in the event of case syncretism other factors influence the identification of syntactic connections between the words in a sentence.
Broad cognitive complaints but subtle objective working memory impairment in fibromyalgia patients
Authors: Pidal-Miranda Marina , González-Villar Alberto Jacobo , Carrillo-de-la-Peña María Teresa , Andrade Elena , Rodríguez-Salgado Dolores 
Published: November 2018

BackgroundCognitive dysfunction in fibromyalgia (FM) encompasses objective cognitive difficulties, as measured in neuropsychological tests, and self-reported cognitive complaints. Although it has been suggested that FM patients display problems in working memory, the data are inconsistent, and the overall working memory status of the patients is unclear. It is also not clear whether the working memory problems are related to cognitive complaints or how the dyscognition is affected by the characteristic clinical symptoms of FM.MethodsTo clarify these aspects, we explored the neuropsychological performance for different components of working memory and the subjective self-perception of cognitive status in a sample of 38 women with FM. They were compared with a matched group of 32 healthy women.ResultsOur findings suggested that the FM patients do not differ from healthy controls in their overall working memory functioning. Only a poor performance was found in a single task of visuospatial working memory, mediated by the presence of depressive symptoms, fatigue and pain. The FM patients also displayed a higher level of perception of cognitive difficulties than healthy controls, and this difference was mediated by depression and fatigue. Furthermore, cognitive complaints in FM patients were only associated with a lower verbal WM capacity.DiscussionFM patients have a subtle specific impairment in their working memory functioning, as well as elevated concern about their cognitive status. These findings suggest a disconnection between neuropsychological performance and subjective complaints. In FM patients, clinical variables such as pain, fatigue, and depression play an important role in dyscognition, as assessed by both objective and subjective measures, and should be taken into account in future research.
Catch fast and kill quickly: do tiger beetles use the same strategies when hunting different types of prey?
Authors: Rewicz Tomasz , Jaskuła Radomir 
Published: November 2018

BackgroundTiger beetles (Coleoptera: Cicindelidae) are fast running predatory insects preying on different small insects and other terrestrial arthropods. Prey is located by sight and captured after short and fast pursuit interspersed with pause-and-look behaviour. At least some tiger beetle species can recognise the size and location of prey using memory, which probably allows them to achieve greater hunting success.Material and MethodsTwo eurytopic tiger beetle species known to occur in different types of habitat were used in the study:Cicindela hybrida hybrida, a very common central European beetle found even in artificial habitats such as sandy roads or gravel pits, andCalomera littoralis nemoralis, a species widely distributed in southern European countries and occurring on sandy sea beaches, in salt marshes, as well as on sandy banks of rivers and lakes. Both species are very similar in body size. Specimens used in the study were collected in the field and later tested in the laboratory. We checked whether tiger beetles use different hunting strategies when attacking prey of different sizes and abilities to escape as well as whether the sex of the studied species makes a difference in its hunting behaviour.ResultsThe hunting strategies of both tiger beetle species consist of the following main phases: identification, pursuit (often with stops), attack, and optional release of the prey, and then the secondary attack, abandonment of the prey, or consumption of the prey. Considerable differences were noticed in hunting behaviour depending on the type of prey, its movement ability and escape potential. Caterpillars were attacked without pursuit, in the head or directly behind the head where a concentration of nerves and main muscles responsible for walking are located. Effective attacks on beetles were executed at the connection between the thorax and the abdomen.Calomera littoralisstrongly preferred slow moving prey, whileCicindela hybridapreferred in equal measure slow moving prey and medium-sized fast moving prey. The experiment on the preferred size of prey indicated small beetles and small caterpillars as favoured byCalomera littoralis, whileCicindela hybridapreferred medium-sized fast moving prey and large caterpillars.DiscussionThe hunting behaviour ofCalomera littoralisandCicindela hybridais complicated and includes a number of phases allowing to locate, capture and kill the prey. Beetles are able to discriminate between different types of prey and apply different behavioural tactics to hunt it. As the particular strategies are used to increase hunting success, and as a result allow to accumulate energy for future activity of the predator, it can be expected that such a type of hunting behaviour is characteristic also of other tiger beetle species.
Δ12 fatty acid desaturase gene from Geotrichum candidum in cheese: molecular cloning and functional characterization
Authors: Luo Xue , Shi Haisu , Wu Rina , Wu Junrui , Pi Yuzhen , Zheng Yan , Yue Xiqing 
Published: November 2018

Soft cheese with white rind lacks essential fatty acids (EFAs), and as a result its long‐term consumption may lead to various kinds of cardiovascular and cerebrovascular diseases, such as hyperlipidemia, hypertension, and atherosclerosis. Geotrichum candidum is a dimorphic yeast that plays an important role in the ripening of mold cheese. A gene coding for Δ12 fatty acid desaturase, a critical bifunctional enzyme desaturating oleic acid (OA) and linoleic acid (LA) to produce LA and α‐linolenic acid (ALA), respectively, was isolated from G. candidum, and then cloned and heterologously expressed in Saccharomyces cerevisiae. This gene, named GcFADS12, had an open reading frame of 1257 bp and codes for a protein of 419 amino acids with a predicted molecular mass of 47.5 kDa. Characterization showed that GcFADS12 had the ability to convert OA to LA and LA to ALA, and the conversion rates for OA and LA were 20.40 ± 0.66% and 6.40 ± 0.57%, respectively. We also found that the protein product of GcFADS12 catalyzes the conversion of the intermediate product (LA) to ALA by addition of OA as the sole substrate. The catalytic activity of GcFADS12 on OA and LA was unaffected by fatty acid concentrations. Kinetic analysis revealed that GcFADS12 had stronger affinity for the OA than for the LA substrate. This study offers a solid basis for improving the production of EFAs by G. candidum in cheese.
Wild‐type p53 regulates OTOP2 transcription through DNA loop alteration of the promoter in colorectal cancer
Authors: Qu Huajun , Su Yi , Yu Lianzhi , Zhao Hongchao , Xin Chunxia 
Published: November 2018

Colorectal cancer (CRC) is the third most commonly diagnosed malignancy worldwide and remains a major public health issue. Therefore, further investigation is required to delineate the cellular and molecular mechanisms underlying colorectal tumorigenesis. Using CRC data taken from The Cancer Genome Atlas, we determined that the expression of otopetrin 2 (OTOP2) is highly correlated with malignancy grade and rate of patient survival. Here, we report that OTOP2 is down‐regulated in cancerous tissues and that elevated OTOP2 effectively suppresses tumor proliferation in vitro. We demonstrate that wild‐type p53 (wtp53), but not mutant p53 (mtp53), can regulate the transcription of otop2 in CRC cells. Subsequently, we investigate the chromatin architecture of the otop2 promoter, whereby we discover alterations in p53‐dependent DNA loop organization and CCCTC‐binding factor (CTCF) binding between cells with wtp53 and mtp53. In conclusion, our study promotes an in‐depth understanding of tumorigenesis, which may also lead to the development of therapeutic applications targeting human malignancy.
MXene‐Enabled Electrochemical Microfluidic Biosensor: Applications toward Multicomponent Continuous Monitoring in Whole Blood
Authors: Liu Jiang , Jiang Xiantao , Zhang Ruyue , Zhang Yang , Wu Leiming , Lu Wei , Li Jianqing , Li Yingchun , Zhang Han 
Published: November 2018

AbstractContinuous and real‐time sensoring has received much attention in biomarker monitoring, toxicity assessment, and therapeutic agent tracking. However, its on‐site application is seriously limited by several stubborn defects including liability to fouling, signal drifting, short service life, poor repeatability, etc. Additionally, most current methods require extra sample pretreatment, delaying timely acquisition of testing results. To address these issues, MXene‐Ti3C2Tx based screen‐printed electrode incorporated with a dialysis microfluidic chip is constructed for a direct and continuous multicomponent analysis of whole blood. Dual‐function of MXene is developed and allows for simultaneous quantification of different target compounds through one device. Importantly, ratiometric sensing tactic is easily implemented in the system, which greatly alleviates signal drifting. As a proof of concept, this novel sensor is applied in hemodialysis, and continuous assay of urea, uric acid, and creatinine levels in human blood is realized. This work paves a new path for 2D MXene in biomedical and sensing applications.
Quasi‐Hodgkin–Huxley Neurons with Leaky Integrate‐and‐Fire Functions Physically Realized with Memristive Devices
Authors: Huang He‐Ming , Yang Rui , Tan Zheng‐Hua , He Hui‐Kai , Zhou Wen , Xiong Jue , Guo Xin 
Published: November 2018

AbstractArtificial neurons with functions such as leaky integrate‐and‐fire (LIF) and spike output are essential for brain‐inspired computation with high efficiency. However, previously implemented artificial neurons, e.g., Hodgkin–Huxley (HH) neurons, integrate‐and‐fire (IF) neurons, and LIF neurons, only achieve partial functionality of a biological neuron. In this work, quasi‐HH neurons with leaky integrate‐and‐fire functions are physically demonstrated with a volatile memristive device, W/WO3/poly(3,4‐ethylenedioxythiophene): polystyrene sulfonate/Pt. The resistive switching behavior of the device can be attributed to the migration of protons, unlike the migration of oxygen ions normally involved in oxide‐based memristors. With multifunctions similar to their biological counterparts, quasi‐HH neurons are advantageous over the reported HH and LIF neurons, demonstrating their potential for neuromorphic computing applications.
One‐Step Generation of a Drug‐Releasing Hydrogel Microarray‐On‐A‐Chip for Large‐Scale Sequential Drug Combination Screening
Authors: Song Seo Woo , Kim Su Deok , Oh Dong Yoon , Lee Yongju , Lee Amos Chungwon , Jeong Yunjin , Bae Hyung Jong , Lee Daewon , Lee Sumin , Kim Jiyun , Kwon Sunghoon 
Published: November 2018

AbstractLarge‐scale screening of sequential drug combinations, wherein the dynamic rewiring of intracellular pathways leads to promising therapeutic effects and improvements in quality of life, is essential for personalized medicine to ensure realistic cost and time requirements and less sample consumption. However, the large‐scale screening requires expensive and complicated liquid handling systems for automation and therefore lowers the accessibility to clinicians or biologists, limiting the full potential of sequential drug combinations in clinical applications and academic investigations. Here, a miniaturized platform for high‐throughput combinatorial drug screening that is “pipetting‐free” and scalable for the screening of sequential drug combinations is presented. The platform uses parallel and bottom‐up formation of a heterogeneous drug‐releasing hydrogel microarray by self‐assembly of drug‐laden hydrogel microparticles. This approach eliminates the need for liquid handling systems and time‐consuming operation in high‐throughput large‐scale screening. In addition, the serial replacement of the drug‐releasing microarray‐on‐a‐chip facilitates different drug exchange in each and every microwell in a simple and highly parallel manner, supporting scalable implementation of multistep combinatorial screening. The proposed strategy can be applied to various forms of combinatorial drug screening with limited amounts of samples and resources, which will broaden the use of the large‐scale screening for precision medicine.