bluuebunny/crossref_metadata_2025_split huggingface dataset:
CHILD-ORAL IMPACTS ON DAILY PERFORMANCE(CHILD-OIDP) IN CHILD PATIENTS IN A ATTENDING DENTAL SCHOOL: A PILOT STUDY
Authors: Kanberoglu E. , Sen B. , Muratoglu B. , Kargul B. 
Published: February 2025

Oral Impacts on Daily Performance (OIDP) assesses impacts of oral health conditions that affect daily activities of an individual and is commonly used as oral health related quality of life (OHRQOL) indicator. The aim of this study was to evaluate OHRQOL in Turkish children attending a dental school by using Child Oral Impacts on Daily Performance (C-OIDP) questionnaire. Methods: This research was approved by Marmara University Institute of Medical Sciences, Noninvasive Clinical Researches Board of Ethics (22.02.2016-24). All relevant information and consent forms were signed by the parents of the patients. The survey was conducted during the period April 2015-January 2016 and information was collected on 72 children aged 8-14 years, attending the dental school in Istanbul, Turkey. A modified questionnaire including sociodemographic information was used. C-OIDP has been validated in Turkey (Can S., Turkish Adaptation of an Index in Foreign Language: Child Oral Impact on Daily Performance. EÜ Dişhek Fak Derg 2009; 30: 97- 103.) Oral impact of daily performance was obtained by adding scores for eight items. During the past 6 months how often have problems arisen with their mouth and teeth which caused them difficulties with 1) eating, 2) speaking, 3) cleaning teeth, 4) sleeping, 5) smiling without embarrassment, 6) emotional status, 7) enjoying social contact and 8) doing homework. Each impact score was calculated by multiplying the frequency (0 to 3) and severity (0 to 3). Then, the scores of the eight performances were summed. Finally, the overall score was the sum divided by 72 (maximum possible score) and multiplied with 100 to give a percentage score. A child can have no oral impact (score = 0) or maximum oral impacts (score = 100). Results: 76 % of children had one or more oral impacts. The mean score of OIDP was 9.16±11.12. Eating was the most common performance affected (n=39, 54%). The prevalence of oral impacts was high for eating and cleaning teeth and low for doing homework and social contact performances. Conclusion: This pilot study revealed that oral impacts on quality of life are prevalent among children attending a University dental clinic for treatment. The impacts are mainly related to difficulty eating. Further longitudinal studies should be performed to better understand OHRQoL measures in children.
OBESITY AMONG DENTAL STUDENTS AND THEIR ORAL HEALTH
Authors: Akyuz S. , Moufti Chousein O. , Yasar D. , Muratoglu B. , Akbas O. , Yarat A. 
Published: February 2025

The aim of this study was to investigate obesity among dental students and their oral health status, and to determine any association between body weight and dental caries. Method: 150 people from 4th and 5th grade students in the 2015-2016 academic year, Marmara University Faculty of Dentistry volunteered to participate in this cross-sectional study. Their oral examination and anthropometric measurements (weight, height, waistline) were done by the same dentist. The volunteers eating, smoking, exercising and brushing habits were collected with a questionnaire. The study was approved by the Ethics Committee of Marmara University. Dental status was evaluated using decayed, missing or filled teeth (DMF-T). Body Mass Index (BMI) was calculated by dividing weight in kg by height squared (kg/m2), and classified in four groups; underweight (<18.50), normal (18.50-24.99), overweight (25.00-29.99), and obese (≥30.00) according to WHO criteria. Males and females were evaluated according to waistline measurements (female; normal 80cm, increased risk 80-87, high risk≥88. Male; normal<94, increased risk 94-101, high risk≥102). Data obtained during the survey were stored in a database (SPSS) and tested for possible statistically differences using the Chi-square test, Anova variance analysis and Pearson correlation analysis. p value<0,05 was considered statistically significant. Results: The students were 73(48.7%) male and 77(51.3%) female. The mean age of students was 24.1(22- 26). The mean DMF-T score was 5 (D:1.3, M:0.4, F:3.3), and 83(55.3%) students had a DMFT score above 4. The high DMF-T scores were mainly filled teeth. 138(92%) of the students reported brushing their teeth once a day. Distribution of the students with underweight, normal weight, overweight and obese according to BMI was 10(6.7%), 110 (73.3%), 24(16%) and 6(4%) respectively. In addition, distribution of the students with normal, increased risk and high risk according to waistline measurements was 126(84%), 17 (11.3%) and 7(4.7%) respectively. As expected, BMI and anthropometric measurements were significantly different between males and females (p<0.001). The number of obese students in all groups was low. DMF-T was higher in the normal weight group than the obese group. The risk for dental caries was not found to be significantly associated with BMI or waistline measurements (p>0.1, r=-0.026, r=-0.051 respectively). Conclusion: We conclude that there is no association between tooth decay and weight in dental students. We speculate that their intellectual levels were high enough to prevent and preserve their oral and general health.
KNOWLEDGE OF DENTISTS TOWARDS ANTIBIOTIC PROPHYLAXIS IN BANDAR ABBAS CITY 2015
Authors: Sadr S. , Masoudi R. , Ansari Fard S. , Akili A. 
Published: February 2025

The aim of this study was to determine Bandar Abbas dentists knowledge of antibiotics prophylaxis in 2015. Methods: This descriptive analytic cross-sectional study involved dentists in Bandar Abbas in 2015. All dentists 137 in the city were invited to take part in the study. A piloted questionnaires with 53 questions on the topics of the need for antibiotic prophylaxis and prophylaxis regimes and an explanatory note were handed out to the dentists and collected in the same day. Multi- variant regression was used for data analysis. Results: One hundred and twenty six dentists completed the questionnaire of whom 69 (53%) were men and 57 (47%) were women. The mean age of participants was 44.9 years. Mean time spent from graduation as a dentist was 11 years. Mean score for correct answers to questions on when and why to provide antibiotic prophylaxis was 72.9 (of a maximum score 104). Sixty three dentists (50%) scored less than 63 (50%). Conclusion: In the sample of dentists, who replied to the questionnaire, 50% showed poor knowledge of when and why to prescribe prophylactic antibiotics. If this is also true for other dentists in Iran there is a need for a national educational program on this topic.
HEALTH ECONOMICS AND INEQUALITIES AFFECTING OVER-THE-COUNTER VERSUS PRESCRIBING DRUGS IN DENTISTRY
Authors: Patel N. , Shah S. , Stagnell S. , Allen Y. 
Published: February 2025

In 2015, in England, dental prescriptions cost £31.2m, an increase of 19.3% from 2014 (£26.2m), continuing the trend of significant increases since 2012. Aims: To identify widely prescribed medicines that are available Over The Counter (OTC); to establish the cost savings of obtaining OTC medicines rather than by prescription. Methods: A review of Health and Social Care Information Centre data was performed to determine the thirty most widely prescribed drugs from the Dental Practitioners Formulary in 2015 that are available as pharmacy only medicines (P) or general sales list medicines (GSL) and to determine the thirty most prescribed drugs with the highest net ingredient cost (NIC) that are also available as P/GSL. A marginal cost analysis was undertaken of these data. Determinants affecting prescribing habits of dentists were outlined. Results: The most commonly prescribed drug, that is also a GSL medicine, was chlorhexidine gluconate (CG) 0.2% mouthwash with 174,180 items dispensed in England in 2015, with a net ingredient cost (NIC) of £841,395. This was the 8th most prescribed dental drug in 2015. This was followed by Corsodyl mouthwash 0.2% (brand name for CG 0.2%) in 10th place with 66,874 items prescribed, costing £220,962. Ibuprofen 400mg was the most widely prescribed analgesic which is also available as a GSL/P with 43,641 items prescribed in 2015, costing £47,187. The marginal saving of obtaining ibuprofen OTC in 2015 rather than by prescription was calculated for the consumption of maximum dosage for 4 days for dental pain, with a typical cost of 50p, saved £25,336.82. Conclusions: There are many medicines which are commonly prescribed which are also available OTC and the cost element of this is a factor all prescribers should be aware of. However, there may be multiple reasons why these medicines are prescribed and decisions should be made on an individual patient basis. Prescribing OTCs for certain patients may be more cost effective when considering the overall benefit to population health.
INVESTIGATING OSCC-SPECIFIC SALIVARY BIOMARKERS IN A HUNGARIAN POPULATION USING TARGETED PROTEOMIC AND IMMUNOLOGICAL METHODS
Authors: Jakob B. , CsŐsz É. , Emri M. , KallÓ G. , MÁrton I. 
Published: February 2025

Oral squamous cell carcinoma (OSCC) is a major health problem globally. Unfortunately Hungary has one of the highest incidences of OSCC in the world, therefore there is a great need for developing sensitive and specific biomarkers. Saliva has become increasingly important as a biological fluid for the detection of diagnostic and prognostic biomarkers. Aim: The aim of this study was to identify and validate biomarkers characteristic for OSCC diagnosis in the Hungarian population. Methods: Ethical approval was obtained from the University of Debrecen Ethics Committee (No. 3385-2011) and the subjects gave informed permission. The study population was formed of 41 patients with OSCC. Twenty four age matched and 10 young healthy volunteers who had no Human Papilloma Virus infection, diabetes mellitus or any autoimmune diseases acted as controls. Fourteen proteins previously identified as potential biomarkers were selected and examined. A targeted proteomics method was developed for catalase, thioredoxin, S100A9, galectin-3 binding protein, cytokeratin 21, profiling, CD44 and CD59. Their level was examined in saliva samples of OSCC patients, age matched controls and young controls. The level of IL-6, IL-8, IL-1b, IL-1a, TNFa and VEGF was examined in saliva samples using a custom 6plex Milliplex kit. The statistical analysis of mass spectrometry data was performed using MStat software. For cytokine measurement, the U-test was used. Results: The levels of protein S100A9, thioredoxin, IL-6 and TNFa were significantly altered in OSCC patients compared to controls (p<0.05). A ROC analysis indicated that the combination of S100A9 and thioredoxin (AUC=0.8) and IL-6 (AUC=0.9) may act as potential OSCC biomarkers applicable for the Hungarian population. For validation, the levels of these potential biomarkers were analyzed in 200 saliva samples collected in a multi centric study from the patients of the four University Medical Centers (Debrecen, Budapest, Pecs and Szeged) in Hungary using ELISA. Conclusions: The results of this study indicate that the combination of protein S100A9, thioredoxin and IL-6 seem to be useful biomarkers for OSCC detection in the Hungarian population.
Validating the socio-spiritual items of the Utrecht Symptom Diary—4 Dimensional: Content and construct validity
Authors: Lormans Tom , de Graaf Everlien , van der Baan Frederieke , Leget Carlo , Teunissen Saskia 
Published: February 2025

Background: The Utrecht Symptom Diary—4 Dimensional (USD-4D) is a multidimensional Patient-Reported Outcome Measure to monitor symptoms and needs and increase patients’ self-efficacy. Assessing the content and construct validity of the USD-4D ensures it accurately measures the intended construct and is contextually relevant. Aims: This study aimed to assess the content and construct validity of the socio-spiritual items of the USD-4D in a population of Dutch patients in the palliative phase of their illness. Design: A multiple method study was performed consisting of a cross-sectional survey and an observational cohort study. Participants: The study population consisted of (a) healthcare providers working with patients in the palliative phase and (b) a cohort of patients with a life limiting illness in all settings supplemented by a cohort of hospice patients. Results: At least 80% of participants positively assessed the items comprehensibility and relevance. About half of the respondents indicated that certain items are missing from the USD-4D. A qualitative analysis of missing topics revealed either topics for monitoring over time or topics underlying the constructs included. For every item, at least 75% of hypotheses were confirmed. One hypothesis for the item “I can let my loved ones go” was rejected. Conclusions: This study confirmed the content and construct validity on the socio-spiritual items of the USD-4D. Hence, the USD-4D is a validated PROM suitable to be structurally used in clinical palliative care to signal, monitor and to go into dialogue about social and spiritual aspects of patients’ values, wishes, and needs.
Enhancing eccentric hip adduction strength in soccer players: A systematic review and meta-analysis of randomized controlled trials
Authors: Alsirhani Ahmed A. , Muaidi Qassim I. , Thorborg Kristian , Husain Mohamed A. , Al Attar Wesam Saleh A. 
Published: February 2025

Background Groin injuries are common in soccer, accounting for 19% of all injuries, with an incidence rate of 0.1–2.1 per 1000 h of play. The Copenhagen Adduction Exercise (CAE) is proposed to increase Eccentric Hip Adduction Strength (EHADS), potentially reducing the risk of groin injuries. Objective This systematic review and meta-analysis evaluated the effectiveness of CAE in improving EHADS among soccer players compared to no intervention or interventions without CAE. Methods A systematic search was conducted in the Cochrane Library, Web of Science, PubMed, and PEDro for randomized controlled trials (RCTs) published between 2012 and 2024. Study quality was evaluated using the revised Cochrane risk of bias tool (RoB2). Results Five RCTs involving 148 soccer players were included. CAE increased EHADS with a mean difference of 0.49 Nm/kg (95% CI [0.28, 0.70], P = 0.00001), compared to interventions without CAE or no intervention. Moderate heterogeneity was observed (I2 = 54%). The risk of bias was low, with minor concerns about deviations from interventions. Conclusions CAE significantly improves EHADS in soccer players, suggesting its potential to reduce groin injury risk when incorporated into training. Study registration PROSPERO (CRD42022327736).
Rising Rate of Hospitalizations in Adolescents with Attention Deficit Hyperactive Disorder in Spain
Authors: Blasco-Fontecilla Hilario , Ramos José Manuel , López-Ibor María Inés , Chiclana-Actis Carlos , Faraco Manuel , González-Cabrera Joaquín , González-Fraile Eduardo , Mestre-Bach Gemma , Pinargote-Celorio Héctor , Corpas Manuel , Gallego Lucía , Corral Octavio , Soriano Vicente 
Published: February 2025

Background: Attention deficit hyperactive disorder (ADHD) is a leading mental disorder among adolescents globally and is associated with premature mortality. Knowing the trends and key determinants of ADHD in youth are critical for earlier diagnosis and interventions. Methods: We retrospectively examined all hospitalizations in patients aged 11 to 18 years with ADHD in Spain, using data from the Spanish National Registry of Hospital Discharges spanning 2000 to 2021. We compared our data with available literature. Results: Over the 22-year study period, there were 2,015,589 hospitalizations among adolescents in Spain, with 118,609 (5.9%) cases involving mental disorders. There were 10,292 admissions with ADHD, representing 8.7% of all hospitalizations among youth with mental disorders. Median age was of 14 years. Boys represented 72.6%. Admissions with ADHD experienced a 17-fold increase during the last decade ( p < .001). The in-hospital mortality rate for adolescents with ADHD was 0.1%, lower than for other mental disorders. During the first year of the COVID-19 pandemic, admissions decreased but resumed its rising trend thereafter. Conclusion: Hospital admissions for ADHD among adolescents have significantly increased in Spain during the last two decades. This increase outpaced the mild upward trend in ADHD diagnoses over the same period, which is not due to actual increases in the incidence of ADHD, which has remained stable at 5% worldwide. Factors beyond increased awareness, improved identification, and changes in diagnostic criteria must be considered. Boys represented 72.6% of these admissions. In-hospital mortality in adolescents with ADHD was lower than for admissions with other mental disorders.
The potential of preoperative dynamic electromyography in guiding targeted surgical procedures for elbow spasticity
Authors: Wang Zheng , Lunasin Ray M. , Hoffman Ernest M. , Rhee Peter C. , Lieber Richard L. , Kaufman Kenton R. 
Published: February 2025

Six patients treated by hyperselective neurectomy were assessed using preoperative dynamic electromyography and intraoperative force measurements. Patients with lower preoperative biceps dynamic electromyography activation had significantly reduced force production at operation, suggesting that these findings could guide and improve procedure selection. Level of evidence: IV
The process of adaptation: Parents’ journey navigating their child's chronic health condition diagnosis
Authors: Thompson Amy L , Smith Sarah L 
Published: February 2025

Purpose This study aimed to examine parents' perceptions and experiences navigating their child's chronic health condition diagnosis. Methods Researchers used a qualitative research design, applying a phenomenological approach to interview 15 parents of children with a chronic health condition. Researchers analyzed verbatim transcripts to develop themes and report strategies that might inform care of the child and parents. Results Parents described a fluid experience navigating their child's diagnosis that involved five interwoven elements: grief, anxiety, unknowing, responsibility, and positivity. Mediating processes of time and experience supported adaptation toward positivity. Experiences appeared to transcend child-specific diagnoses suggesting a common process of parent adaptation to a child's diagnosis. Conclusion Findings elucidate parents’ lived experiences surrounding their child's diagnosis of a chronic health condition. Parents are inextricable from their child's care; thus, findings may garner knowledge supporting providers to employ strategies that support favorable outcomes for both children and parents.
Comparative therapeutic and prophylactic efficacy of ethanol and water extracts of ginger in alleviating acetaminophen-induced hepatotoxicity and dyslipidemia
Authors: Abdel-Rasol Mohammed A , El-Beih Nadia M , El-Sayed Wael M 
Published: February 2025

Background:  Acetaminophen (APAP) overdose, common during pandemics like COVID-19, causes liver injury through oxidative stress. Ginger, known for its antioxidant properties, is suggested as a potential natural remedy. Objective:  This study aimed to evaluate the therapeutic and prophylactic efficacy of ethanol ginger extract (GE) and ginger suspension (GS) on APAP-induced hepatotoxicity and dyslipidemia in rats. Methods:  Rats were assigned to ten groups: a control group, dimethyl sulfoxide group, and groups receiving either GE or GS (150 mg/kg) for two weeks. A group given a single high dose of APAP (2500 mg/kg), groups pre-treated with GE or GS before a single dose of APAP, a group receiving three repeated doses of APAP (500 mg/kg), and groups co-administrated GE or GS along with APAP over two weeks. Results:  APAP administration at the two regimens significantly impaired liver function, antioxidant defenses, and lipid metabolism. These disruptions included reduced levels of antioxidant markers such as reduced glutathione (GSH), catalase (CAT), superoxide dismutase (SOD), glutathione S-transferase (GST), glutathione reductase (GR), glutathione peroxidase (GPx), and glucose-6-phosphate dehydrogenase (G6PDH). Lipid metabolism alterations were evident from increased triacylglycerols (TAGs), total cholesterol (T-chol), low-density lipoprotein cholesterol (LDL-chol), alongside decreased high-density lipoprotein cholesterol (HDL-chol). The high dose of APAP resulted in severe damage, indicated by elevated malondialdehyde (MDA), alanine aminotransferase (ALT), alkaline phosphatase (ALP), and altered protein fractions. Both GE and GS treatments significantly alleviated these APAP-induced changes, particularly in MDA, ALT, GPx, and LDL-chol levels. GE demonstrated superior protective effects compared to GS, particularly in restoring levels of GSH, ALP, CAT, SOD, GST, GR, G6PDH, HDL-chol, albumin and alpha-1 globulins. In contrast, GS showed slightly greater effects on reducing TAGs and T-chol levels. Conclusions:  Ginger extracts offer significant protection against APAP-induced liver damage and dyslipidemia, with GE providing more pronounced therapeutic effects.
The application of artificial intelligence in stroke research: A bibliometric analysis
Authors: Peng Yun , Zhao Zhen , Rao Yutong , Sun Ke , Zou Jiayi , Liu Guanqing 
Published: February 2025

Background Currently, artificial intelligence (AI) has been widely used for the prediction, diagnosis, evaluation and rehabilitation of stroke. However, the quantitative and qualitative description of this field is still lacking. Objective This study aimed to summarize and elucidate the research status and changes in hotspots on the application of AI in stroke over the past 20 years through bibliometric analysis. Materials and Methods Publications on the application of AI in stroke in the past two decades were retrieved from the Web of Science Core Collection. Microsoft Excel was used to analyze the annual publication volume. The cooperation network map among countries/regions was generated on an online platform ( https://bibliometric.com/ ). CiteSpace was used to visualize the co-occurrence of institutions and analyze the timeline view of references and burst keywords. The network visualization map of keywords co-occurrence was generated by VOSviewer. Results A total of 4437 publications were included. The annual number of published documents shows an upwards trend. The USA published the most documents and has the top 3 most productive institutions. Journal of Neuroengineering and Rehabilitation and Stroke are the journals with the most publications and citations, respectively. The keywords co-occurrence network classified the keywords into four themes, that is "rehabilitation," "machine learning," "recovery" and "upper limb function." The top 3 keywords with the strongest burst strength were "arm," "upper limb" and "therapy." The most recent keywords that burst after 2020 and last until 2023 included "scores," "machine learning," "natural language processing" and "atrial fibrillation." Conclusion The USA shows a leading position in this field. At present and in the next few years, research in this field may focus on the prediction/rapid diagnosis of potential stroke patients by using machine learning, deep learning and natural language processing.