bluuebunny/crossref_metadata_2025_split huggingface dataset:
Regeneration of Chronic Alveolar Vertical Defects Using a Micro Dosage of rhBMP‐2. An Experimental In Vivo Study
Authors: Urban Istvan A. , Farkasdi Sándor , Bosshardt Dieter D. , Araujo Mauricio G. , Ravidà Andrea , Becker Kathrin , Kerberger Robert , Wang Hom‐Lay , Wikesjö Ulf M. E. , Varga Gabor , Saleh Muhammad H. A. 
Published: November 2024

ABSTRACTObjectiveThe objective of this study is to compare the effect of the location of recombinant human bone morphogenetic protein 2 (rhBMP‐2) from the native bone and the periosteum for vertical alveolar bone augmentation.Materials and MethodsMandibular, chronic, standardized, bilateral, and vertical defects in 12 beagle dogs were evaluated using four modalities: a xenograft alone (XENO; n = 6); rhBMP‐2 alone (BMP; n = 6); a technique with rhBMP‐2 close to the host bone covered by xenograft (SAN; n = 6); and a technique with rhBMP‐2 close to the flap on top of the xenograft (LAS; n = 6). After 8 weeks, a series of in vivo inspections, fluorescence microscopy, histologic and histomorphometric evaluations, and micro‐CT analyses.ResultsAfter 8 weeks of healing, new bone formation correlated with proximity of rhBMP to the perforated membrane with BMP and LAS (p = 0.024). The highest total bone volume was found in the LAS group (45.1% ± 13.3%), followed by the SAN group (35.2% ± 6.7%), BMP group (33.1% ± 11.8%), followed by the XENO group (23.1% ± 6.5%). The SAN group demonstrated frequent seroma formation. Blood vessel formation was more pronounced in the LAS + rhBMP group, with a significant increase of 27.1% compared to the XENO group (p = 0.02). Micro‐CT revealed a strong trend for higher bone volume in the BMP group (34.7%) compared to the XENO group (13.6%) (p = 0.06). Only rhBMP‐2 groups demonstrated bone formation above the perforated membrane.ConclusionThe location of rhBMP‐2 in relation to the biomaterial and periosteum influenced the effectiveness of vertical bone regeneration.
Longitudinal relationship between hip displacement and hip function in children and adolescents with cerebral palsy: A scoping review
Authors: Malone Ailish , Tanner Giorgia , French Helen P. 
Published: November 2024

AbstractAimTo identify, describe, and synthesize available evidence on the longitudinal relationship between hip displacement and hip function, using the International Classification of Functioning, Disability and Health (ICF) framework, in children and adolescents with cerebral palsy (CP) aged up to 18 years.MethodFive databases were searched systematically from inception to May 2022. Study and sample characteristics, and hip displacement and hip function measures, mapped to the ICF domains, were extracted for narrative synthesis.ResultsTwenty‐nine studies were included: four longitudinal registry‐based studies; 12 prospective studies; 12 retrospective studies; and one randomized controlled trial. Sample size ranged from 11 to 267. Twenty‐seven (93%) studies entailed an intervention: surgery (n = 16); rehabilitation (n = 2); nerve block or botulinum neurotoxin A injection (n = 4); and combined surgery and injection (n = 2). Twenty‐six studies (90%) reported outcomes at the body structure and function and impairment domain of the ICF; 17 (59%) reported outcomes in the activity domain; and three (10%) included participation measures. The most common hip displacement measure was Reimers' migration percentage (79%).InterpretationBecause of the inclusion of interventions in most studies, and the preponderance of retrospective studies, the relationship between hip displacement and hip function in CP is unclear. More high‐quality prospective evidence on the natural history of hip displacement, and its effect on function, is needed to improve population‐wide screening of children with CP.
Effect of heavy metal on growth of black soldier fly larvae (Hermetia illucens): Accumulation, excretion and gut microbiome
Authors: Liu Shuang , Lang Huilin , Zhao Jia , Hao Jianwei 
Published: November 2024

AbstractThe larvae of black soldier fly, Hermetia illucens (L.) (Diptera: Stratiomyidae), are an excellent source of feed for animals and have emerged as a promising candidate for waste disposal. The larval growth can be impacted by the intake of heavy metals. However, the underlying mechanism for metal tolerance of the gut microbiome is still poorly understood, as well as how heavy metals, especially in combination, affect the communities of bacteria in the larval gut. Therefore, in this study we focus on how Cu and Zn affect larval growth and gut microbiome, as well as how bioaccumulated heavy metals are distributed in larval residues and bodies. The larval biomass growth was both significantly improved and inhibited by exposure to low and high Cu and Zn concentration, respectively, including in combination. The amount of accumulated Cu and Zn in larval residues and bodies significantly increases as the exposure concentration is increased. In larval bodies, Zn was more likely to be accumulated (57.2%–78.5%) than Cu (<40%). More importantly, the larval gut microbiome was found to be remarkably altered by Cu and Zn exposure, particularly for species of the phyla Actinobacteria, Bacteroidetes, and Firmicutes. In addition, with the exception of the Cu at 400 mg kg−1 exposure, the diversity and complexity of the gut bacterial community significantly decreased. Functional genes related to heavy metal resistance and transport, such as pcoB, pcoD, copC, pccA, ABC.ZM.S, and yahk, were clearly enriched in the larval gut, which may help to partly account for the ability of black soldier fly larvae to tolerate metals.
Structural connectivity changes in focal epilepsy: Beyond the epileptogenic zone
Authors: Barrios‐Martinez Jessica V. , Almast Anmol , Lin Ivan , Youssef Aya , Aung Thandar , Fernandes‐Cabral David , Yeh Fang‐Cheng , Chang Yue‐Fang , Mettenburg Joseph , Modo Michel , Henry Luke , Gonzalez‐Martinez Jorge A. 
Published: November 2024

AbstractObjectiveEpilepsy is recognized increasingly as a network disease, with changes extending beyond the epileptogenic zone (EZ). However, more studies of structural connectivity are needed to better understand the behavior and nature of this condition.MethodsIn this study, we applied differential tractography, a novel technique that measures changes in anisotropic diffusion, to assess widespread structural connectivity alterations in a total of 42 patients diagnosed with medically refractory epilepsy (MRE), including 27 patients with focal epilepsy and 15 patients with multifocal epilepsy that were included to validate our hypothesis. All patients were compared individually to an averaged database constructed from 19 normal controls regressed by age and sex.ResultsStatistical analyses revealed specific distribution patterns of tracts with increased connectivity that were located in multiple subcortical structures across all patients including the arcuate fasciculus, inferior fronto‐occipital fasciculus, inferior longitudinal fasciculus, uncinate fasciculus, fornix, and short U fibers. Conversely, pathways with a significant decrease in connectivity (p < .05) exhibited a more central distribution near mesial structures across all patients (corpus callosum, cingulum, corticospinal tract, and sensory fibers).SignificanceOur findings add to the growing evidence that focal epilepsy is not solely anatomically confined, but is rather a network disorder that extends beyond the EZ, and differential tractography shows strong potential as a clinical biomarker for assessing structural connectivity alterations in patients with epilepsy.
Intrusion Detection Using CTGAN and Lightweight Neural Network for Internet of Things
Authors: Das Sudeshna , Majumder Abhishek , Namasudra Suyel , Singh Ashish 
Published: November 2024

ABSTRACTDeep learning‐based intrusion detection systems have high accuracy and low false alarm rates. However, there are challenges to deploy deep learning models in the vulnerable, resource‐constrained Internet of Things. Therefore, two deep learning models are proposed: Lightweight Intrusion Detection System using Feedforward Neural Network (LIDSuFNN) and Lightweight Intrusion Detection System using Convolutional Neural Network (LIDSuCNN). In the models, the feedforward neural network is compressed using neuron pruning and the convolutional neural network is compressed using filter pruning. Then, quantization has been applied to the models. The models are trained and tested on standard datasets and synthetic datasets. A generative artificial intelligence model, Conditional Tabular Generative Adversarial Network (CTGAN), has been used to generate synthetic data. The models have been compared with the baselines and results are analyzed. Experimental results show that the proposed models require less training time and memory than the baselines, with approximately similar performance. The reduction of various parameters is due to the fact that pruning and quantization have removed unnecessary calculations from the networks. Statistical analysis has also been done to show the superiority of the proposed techniques.
Theses and dissertations completed in family and consumer sciences: 2023
Authors: Hinson Jacinta D. , Alexander Karen L. 
Published: November 2024

AbstractCompletion of family and consumer sciences graduate degrees and research has been collected annually and published in the Family and Consumer Sciences Research Journal since 1992. Data collection for 2023 began in September 2024 when 528 emails were sent to contacts at 163 U.S. universities and colleges inviting FCS programs to report graduate program degree completions and research production through submission of titles for theses and dissertations. The 46 responding institutions reported 1550 graduate degrees conferred collectively with 241 master's theses, 282 dissertations, and 1027 non‐thesis master's degrees completed. This report presents information submitted by these institutions on 232 theses and 256 dissertations organized by 17 subject‐matters categories and degree level.
Boundary‐Spanning and Sustainability in the Digital Higher Education Space: A Case Study of Anadolu University
Authors: Özdemir Murat , Kesik Fatma , Uslu Barış , Aypay Ahmet , Çalıkoğlu Alper 
Published: November 2024

ABSTRACTThis research explores how boundary‐spanning efforts in higher education can be expanded through the digital space and contribute to sustainability in higher education. By employing a qualitative case study design, we examine the journey of a Turkish public university's open education faculty, focusing on how the university has leveraged its open education mission and the developments in digital space to span boundaries and contribute to societal development constantly. Alongside reviewing institutional documents, we interviewed with 12 faculty members at the case institution. Benefitting from an inductive descriptive thematic analysis approach, we categorised related strategies and experiences into three themes: key agents, drivers and challenges and sustainability. The findings reveal that universities can better position themselves in the digital education space if the leadership embraces a clear vision regarding digital evolvement. Also, national regulations influence the digital development of universities and lead them to push boundaries in generating new teaching‐learning, research and service platforms. Our research demonstrates that by enhancing digital environments and online technologies, universities can extend their collaboration with different stakeholders and maintain boundary‐spanning efforts to improve their societal contribution. Further discussions and recommendations are made on the role of digital space in boundary spanning and sustainability in higher education.
Hair loss in athletic testosterone use in males: a narrative review
Authors: Tawanwongsri Weeratian , Desai Deesha D. , Nohria Ambika , Shapiro Jerry , Lo Sicco Kristen I. 
Published: November 2024

AbstractPerformance‐enhancing drugs, such as testosterone, are used by athletes and youth to increase muscle growth and strength, particularly among males. However, these therapies potentially pose health risks, including liver toxicity, gynecomastia, and hair loss. Testosterone use is rising for performance enhancement, physical appearance, and resistance training, but there remains an absence of standardized guidelines for safe dosages. This study examines the relationship between testosterone use and hair health in males, aiming to develop guidelines for safe, responsible testosterone use. Understanding treatment outcomes in this context is crucial for informed healthcare.
Does Design Matter? The (Limited) Effects of Six Asynchronous Video Interview Design Features on Impression Management, Reactions, and Evaluations
Authors: Lukacik Eden‐Raye , Bourdage Joshua S. 
Published: November 2024

ABSTRACTAsynchronous video interviews can use many configurations of design features to create the interviewee experience, but not all designs are equal. Design features may influence interviewees' deceptive and honest impression management, their reactions to the procedure, and interview performance evaluations. Three experiments using mock interviews tested the effects of preparation time and self‐views (N = 206, from Prolific), reviewing and re‐recording (N = 230, from Prolific), and giving faking warnings with human versus automated evaluation (N = 297 university students) on interview outcomes. The design had limited effects on interviewee behavior, but some features may increase interviewees' willingness to fake when used in combination. Opportunities for longer preparation time and re‐recording increased interview performance ratings. Warnings and evaluator type did not affect behavior, reactions, or performance. The implications of these effects are discussed.
The health‐economic impact of urine albumin‐to‐creatinine ratio testing for chronic kidney disease in Japanese patients with type 2 diabetes
Authors: Asahi Koichi , Konta Tsuneo , Tamura Kouichi , Tanaka Fumitaka , Fukui Akira , Nakamura Yusuke , Hirose Junichi , Ohara Kenichi , Shijoh Yoko , Carter Matthew , Meredith Kimberley , Harris James , Åkerborg Örjan , Kashihara Naoki , Yokoo Takashi 
Published: November 2024

ABSTRACTAims/IntroductionThis analysis seeks to evaluate the cost‐effectiveness of urine albumin‐to‐creatinine ratio testing compared with urine protein‐creatinine ratio testing and no urine testing for the identification of kidney damage in individuals with type 2 diabetes who have, or are at risk of, chronic kidney disease in Japan.Materials and MethodsA health‐economic model estimated the clinical and economic consequences of different tests to evaluate kidney damage in line with Japanese guidelines, taking a Japanese healthcare perspective. Differences in the diagnostic performance of tests were considered by the integration of real‐world Japanese data. Outcomes were considered over a lifetime horizon, and included costs, prevented dialyses, life years gained, quality‐adjusted life years, and incremental cost‐effectiveness ratios.ResultsRepeated urine albumin‐to‐creatinine ratio testing was found to be cost‐effective compared with both urine protein‐creatinine ratio testing and no urine testing, yielding incremental cost‐effectiveness ratios of ¥2,652,693 and ¥2,460,453, respectively.ConclusionsRepeated urine albumin‐to‐creatinine ratio testing is cost‐effective compared with urine protein‐creatinine ratio testing and no urine testing in Japanese individuals with type 2 diabetes, supporting existing clinical evidence that albumin‐to‐creatinine ratio testing should be used more widely, particularly compared with other urine tests such as urine protein‐creatinine ratio testing.
Association between severity of diabetic complications and risk of cancer in middle‐aged patients with type 2 diabetes
Authors: Tseng Yao‐Hsien , Tsan Yu‐Tse , Chen Pau‐Chung 
Published: November 2024

ABSTRACTAimHyperglycemia was found to be associated with an increased risk of cancer in a general population cohort. However, it remains to be established whether the severity of diabetic complications is associated with cancer risk in patients with diabetes.Materials and MethodsWe used the National Health Insurance Research Database from 2000 through 2013, including those with newly diagnosed diabetic patients (n = 616,742). We collected all vascular and metabolic complications to develop an adapted diabetic complication severity index (aDCSI), ranging from 0 to 13 annually, as proxies of the severity of diabetic complications and performed follow‐up from the onset of diabetes until incident cancer, death, or the study end.ResultsWithin the mean follow‐up period of 9 years, the rates of cancer incidence per 100,000 person‐years were 815.2 vs 482.0 and 611.1 vs 358.9 for the top vs bottom quartiles, respectively, of aDCSI in men and women (adjusted HRs 1.17 (95% CI 1.10–1.25) and 1.20 (95% CI 1.10–1.30), respectively). The risk of cancer was 1.7‐ to 1.9‐fold for the top vs bottom quartiles of aDCSI in diabetic onset age of 40–44 (HRs 1.74 (95% CI, 1.39–2.18) in men and HRs 1.93 (95% CI, 1.39–2.66) in women). However, among patients with diabetic onset age of 60–64, the associations between the severity of diabetic complications and cancer risk were attenuated.ConclusionsPatients with higher severity of diabetic complications have an increased risk of cancer compared to those with the lowest severity, particularly for those with earlier onset and greater severity of diabetic complications.
Follicular Cell Hyperplasia (Goitre), Adenoma and Adenocarcinoma of the Thyroid Gland in Fourlined Terapon (Pelates quadrilineatus): Clinical and Histopathological Study: 2022–2023
Authors: Rahmati‐Holasoo Hooman , Shokrpoor Sara , Marandi Amin 
Published: November 2024

ABSTRACTThyroid disorders can manifest in several forms, including follicular cell hyperplasia (goitre), follicular cell adenoma and follicular cell carcinoma. Following the detection of large and gradually increasing tumour‐like masses in the gular region of wild fourlined terapons (Pelates quadrilineatus) housed in various tanks in a public aquarium in June 2022, September 2022 and October 2023, several fish displaying clinical signs were transported to the Ornamental Fish Clinic at the Faculty of Veterinary Medicine, University of Tehran. Upon clinical inspection, the fish had prominent tumour‐like masses in the gular area, located beneath the operculum. Upon histological examination of the first series, the masses revealed thyroid well‐differentiated hyperplastic follicles that contained colloid and were lined by cuboidal epithelial cells. There were no signs of cellular atypia or mitotic figures. The study of the second series also revealed the existence of cellular atypia, but still no mitotic figures. In the examination of the third series, apart from the earlier lesions, there was evidence of neoplastic cell invasion into adjacent structures such as the adipose tissue and subepithelial layer. In addition, there was moderate cellular pleomorphism and a limited number of mitotic figures. Although the termination of water ozonation and the addition of potassium iodide to the feed were effective in treating thyroid hyperplasia, the treatment for thyroid neoplasia was not successful. The present study provides the evidence of clinical and histopathological findings of follicular cell hyperplasia, adenoma and adenocarcinoma of the thyroid gland in fourlined terapon.
Monitoring Fish Bacterial Pathogens of Wild Fish Species From the South China Sea by Applying Next‐Generation Sequencing on Gill Tissue
Authors: Zrihan Shlomi , Itay Peleg , Kroin Yael , Davidovich Nadav , Wosnick Natascha , Tchernov Dan , Koh Xiu Pei , Lau Stanley C. K. , Morick Danny 
Published: November 2024

ABSTRACTThe classic epidemiological triangle model of host—environment—pathogen is recently being reshaped into a tetrahedron, with the growing understanding of the importance of the microbiome in this array. The gills, being a gateway into the fish body, bearing an important role in fish homeostasis, host a complex microbiome that reflects the ambient water, while also showing resemblance to gut microbiome. Next‐generation sequencing (NGS) and improvements in data analysis tools enable researchers to gather and analyse a lot more data than ever before, take a closer, more detailed look at microbiota, and gain a much better understanding of the biological processes at work in these complex relations. Here, 16S rRNA amplicons of bacterial DNA extracted from the gills of 36 asymptomatic specimens of three wild fish species from the South China Sea (Nemipterus japonicus, Alepes djebaba, and Saurida tumbil) were sequenced using NGS. Data analyses revealed the presence of 20 potentially pathogenic species, including several zoonotic agents. Gill microbiota exhibited host species‐specificity, and expressed a significant difference between demersal and pelagic‐amphidromous fish. It is suggested that this method be more widely implemented, in order to gain more insight on ocean ecosystems’ health status, as well as fish stocks of commercial importance.
The role of combined FDG and SST PET/CT in neuroendocrine tumors
Authors: Di Franco Martina , Fortunati Emilia , Zanoni Lucia , Fanti Stefano , Ambrosini Valentina 
Published: November 2024

AbstractSomatostatin receptor (SST) positron emission tomography with computed tomography (PET/CT) is the gold standard for functional imaging of neuroendocrine tumors (NETs), but FDG PET/CT is increasingly recognized for its prognostic value, particularly for higher‐grade NETs and to detect disease heterogeneity. Despite the established role of pathological grading, clinical heterogeneity within the tumor burden often complicates accurate prognostication. Evidence suggests FDG PET/CT can outperform WHO grading in predicting outcomes by identifying aggressive, undifferentiated tumor clones that influence long‐term prognosis and treatment decisions. Several grading systems integrating both SST and FDG PET/CT have been proposed to better capture tumor heterogeneity and guide clinical management. Studies demonstrate that FDG PET/CT can influence management in a significant subset of patients, although variably reported. Its use remains variable across centers, also affected by different reimbursement policies and local clinical practices. This review explores the indications to FDG PET/CT in NET and the clinical impact of combined SST and FDG PET/CT imaging.
Exploring potential pathways from oxidative stress to ovarian aging
Authors: Kobayashi Hiroshi , Imanaka Shogo 
Published: November 2024

AbstractAimIn developed nations, women have increasingly deferred childbearing, leading to a rise in demand for infertility treatments and the widespread use of assisted reproductive technologies. However, despite advancements in in vitro fertilization (IVF), live birth rates among women over 40 remain suboptimal. Mitochondrial dysfunction is widely recognized as a key factor in the processes driving the age‐related deterioration in both the quantity and quality of oocytes. We aim to summarize current insights into ovarian aging, with a particular focus on pathways that impair mitochondrial function, and explore directions for future research.MethodsElectronic databases were searched for articles published up to June 30, 2024.ResultsOngoing ovulation, luteolysis, and menstruation trigger exogenous reactive oxygen species (ROS)‐mediated oxidative stress that damages mitochondrial DNA. This, in turn, reduces nuclear gene expression, compromises mitochondrial oxidative phosphorylation, and diminishes adenosine 5′ triphosphate production. Persistent endogenous ROS further exacerbate mitochondrial DNA damage and aneuploidy, ultimately causing irreversible chromosomal abnormalities, leading to oocyte aging.ConclusionsWe have delineated the pathway from oxidative stress to ovarian aging. Early detection and management of ovarian aging present challenges and opportunities to enhance IVF treatment strategies.