bluuebunny/crossref_metadata_2025_split huggingface dataset:
Neuroprotective Effects of Rapid Local Ischemic Postconditioning in Successful Endovascular Thrombectomy Patients
Authors: Deng Jiangshan , He Guangchen , Yi Tingyu , Wei Liming , Lu Haitao , Zhou Qing , Yao Ye , Zhu Chengcheng , Levitt Michael R. , Mossa-Basha Mahmud , Yang Haibo , Shen Yi , Shi Feng , Wang Duolao , Lin Longting , Parsons Mark , Chen Wenhuo , Zhu Yueqi 
Published: November 2024

BACKGROUND:
We aim to assess the efficacy of rapid local ischemic postconditioning (RL-IPostC) following successful reperfusion in patients with acute ischemic stroke with anterior circulation large vessel occlusion who underwent endovascular thrombectomy.

METHODS:
We conducted an ambidirectional cohort study with 78 prospectively enrolled patients with RL-IPostC and endovascular thrombectomy and 129 retrospectively enrolled patients with endovascular thrombectomy. The RL-IPostC procedure involved 5 cycles of 15-s balloon inflation and deflation in the ipsilateral internal carotid artery. The primary outcome was functional independence, defined as a modified Rankin Scale score of 0 to 2. Secondary outcomes included excellent outcomes (modified Rankin Scale score, 0–1) and early therapeutic response. Imaging outcomes involved infarct volume changes and cerebral edema measurements. Outcomes were compared with postpropensity score matching (1:1) and assessed using univariable and multivariable regression models.

RESULTS:

In the matched cohort of 136 patients (mean age, 71±14 years; 70 men [51%]), RL-IPostC was associated with a higher rate of functional independence (adjusted odds ratio, 2.47 [95% CI, 1.10–5.68];
P
=0.030). The RL-IPostC group exhibited significantly reduced infarct volumes at 24 hours (difference, −12.2 [95% CI, −23.9 to −0.53];
P
=0.041) and less infarct growth (difference, −12.2 [95% CI, −23.9 to −0.45];
P
=0.042). Furthermore, RL-IPostC correlated with lower increases in net water uptake (difference, −0.04 [95% CI, −0.07 to −0.01];
P
=0.018), lower decrease cerebrospinal fluid volume (difference, −7.75 [95% CI, −11.7 to −3.84];
P
<0.001), and reduced midline shift at 24 hours (difference, −1.39 [95% CI, −2.48 to −0.30];
P
=0.013).

CONCLUSIONS:
RL-IPostC tends to promote functional independence and reduces infarct growth and cerebral edema in patients with acute ischemic stroke post-reperfusion.
“Why Is the Old Dying and the New Is Not Being Born?” The Church’s Struggle with Public Justice and Righteousness in Zimbabwe
Authors: Gaga John 
Published: November 2024

Abstract
This article attempts to present how the church has struggled with public justice and righteousness in Zimbabwe where the past and old dominate the national debate without giving room for emerging personalities and ideas. The church introduced programmes, organisations and documents in an attempt to theoretically break away with the past. The documents are results of transformative projects designed to address the holistic needs of people in Zimbabwe against both the localised and internationalised neoliberal paradigms of Capitalism, Colonialism and Christianity that disempowered rather than liberated followers. Being critical of the past, Derrida says: “To ask such questions, such difficult questions, requires that we change the most resistant, archaic structures of our desire”. The Zimbabwe Heads of Christian Denominations (ZHOCD s) introduced the post-liberation discourse through the Zimbabwe We Want Document (ZWWD) in 2006, and a national economic discussion through the National Holistic Agenda for Renewal and Empowerment (NHARE) in 2019 against the idea that the Church must be confined in the pews and politicians in the public arena. These documents and programmes engaged with both politicians and citizens in critical ways to achieve both justice and righteousness. Justice and righteousness are big themes in the Bible and Christian doctrine. Breaking away with the past promised to reverse the slippery slope on public life in Zimbabwe that increased national poverty, class inequalities, and factionalised politics. The opening of space in public life by the ZHOCD allowed citizens to engage in all public life and justice struggles, which is “a revival of a voice that has been silenced after independence, or was send to the Intensive Care Unit (ICU), paralysed, captured, neutralised or unauthorised”. It explored new alternatives to engaging state theology in relationship to the margins. Scripture has been useful in the church’s engagement with the state on public life goods, hence the question: “Why is the old dying and the new not being born”? The article pursues this question in view of the church programmes and documents.
A Theological and Contextual Exploration of James Torrance’s Covenant or Contract?
Authors: Maclean Hamish 
Published: November 2024

Abstract
The covenant concept is a central theme original to the Bible and is generally defined as a formal commitment between two parties. James Torrance’s theological definition of a covenant is employed in this article to highlight two critical characteristics. It then explores Torrance’s claim of a legacy of confusion between a covenant and a contract in theology and discovers that this ambiguity is true of some historical and current scholarship. Torrance’s insights are applied to a contentious contextual example that has played out in New Zealand around the Treaty of Waitangi: the case is made for identifying how Torrance’s theological understanding of a covenant can lead into positive steps forward and thus contribute to a public theology.
Introduction
Authors: Hornkohl Aaron D. 
Published: November 2024

Despite the suitability of the standard division of Biblical Hebrew (BH) into pre-exilic Classical Biblical Hebrew (CBH) and post-Restoration Late Biblical Hebrew, which presupposes the linguistic unity of the classical phase in which most of the Hebrew Bible is written, there is some evidence pointing to diachronic diversity within CBH, according to which the Torah presents an earlier chronolect than the pre-exilic Prophets and Writings. The implications are significant, not just as they demand greater nuance in the accepted, fundamentally dichotomous theory of BH periodisation, but challenge entrenched theories of the Bible’s literary composition.
This introductory chapter surveys challenges presented by the data, emphasises the need for external controls and a robust methodology, responds to oft-raised objections to diachronic linguistic approaches, and previews the structure of the monograph.
11. Abstract Nouns Ending in -ūt
Authors: Hornkohl Aaron D. 
Published: November 2024

Elitzur (2018a) examines the occurrence of abstract nouns ending in -ūt in the Masoretic tradition of the Hebrew Bible, noting a distinct pattern that distinguishes the Pentateuch from other biblical texts. His analysis highlights that these nouns are relatively rare in the Pentateuch and often written defectively, while they are more frequent and usually spelled plene (with waw) in the Prophets and Writings. Elitzur investigates specific examples such as גַּבְלֻת ‘twistedness’ and עֵדֻת ‘testimony’ to support this observation. He raises the question of whether the defective spelling in the Pentateuch signifies a historical mismatch between written and spoken forms or if many words with defective -ūt originally ended with a different suffix, later adapted under changing linguistic norms.
Building on and extending Elitzur’s study, the discussion reveals the complexities of diachrony in Hebrew, particularly regarding the -ūt endings, which are often deemed characteristic of later forms of the language. Cohen (2012) has challenged this characterisation, arguing that their distribution is comparable within both the Torah and later texts. The chapter problematises this viewpoint, suggesting that the focus should be on the frequency of tokens rather than on mere number of lexemes. Among other things, it is pointed out that the orthographic discrepancies in the usage of -ūt in the Torah could reflect underlying morphological differences, i.e., that they might represent a later reinterpretation of forms that originally had different suffixes. Ultimately, the evidence suggests a complex interplay between orthography and morphology, underscoring the challenges in tracing the historical development of these noun forms in biblical Hebrew.
Understanding Decadal-Scale Dynamics in the Bering Sea: Investigating Trends and Variability in Sea Ice, Winds, and Waves
Authors: Fischer Reint , Farrell Sinead L. , Kuhn John M. , Duncan Kyle 
Published: November 2024

Abstract
Despite the societal and economic importance of the Bering Sea, recent rapid changes in surface ocean conditions are not well documented. We address this gap by characterizing the Bering Sea winter ice–wind–wave climate using satellite observations and reanalysis data. Nine of the last 10 years (2014–23) have experienced anomalously low sea ice extent relative to the 1980–2023 mean. Between 2003 and 2023, gale force wind speeds have become more common and satellite altimeter observations show significant wave height (SWH) has increased ≥6 m, and has increased by 1 m between 2003 and 2023, while 20 days yr−1 exhibit SWH > 9 m. Winters between 2018 and 2023 were the six stormiest since 2003, and the sea ice season decreases by 1–4 days yr−1. Should ice loss in the Bering Sea continue to decline, we hypothesize that the frequency of extreme waves over the Bering Sea shelf would increase, severely impacting coastal communities. In September 2022, extratropical cyclone Merbok caused unprecedented SWH (>15 m) over the shelf which were uncharacteristic for the season, and caused widespread coastal inundation and property damage. Such anomalous wave conditions exemplify the emerging threat storms pose in a future where sea ice is absent more frequently in winter, when severe storms are most common. Satellite altimeters have improved the observation of surface ocean conditions in the Bering Sea during the most intense storms, and we demonstrate that a suite of five or more altimeters is required to capture regional events adequately.

Significance Statement
Although the Bering Sea region has recently endured rapid sea ice loss and the decline of several species important for subsistence and commercial fishing, it has relatively few resources to monitor and mitigate changing climatic conditions. In this article, we show that extreme wind and wave conditions in the Bering Sea have strongly increased in recent years, as sea ice has declined. This points to a need for reliable and continued monitoring, and with only two wave buoys providing year-round observations, an adequate constellation of ocean remote sensing instruments is required to capture extreme ocean–ice–atmosphere events in an isolated and challenging environment.
Establishment of a Predictive Model for Seroma Formation After TAPP Repair for Unilateral Indirect Inguinal Hernia in Males
Authors: Peng Xue-Feng , Yu Miao , Wang Deng-Chao 
Published: November 2024

Background Inguinal hernia repair, particularly using TAPP, is common in males, and acclaimed for minimal invasiveness but often complicated by seromas, significantly affecting recovery and health care costs. Methods This retrospective study analyzed data from 266 male patients with unilateral indirect inguinal hernia who underwent transabdominal preperitoneal (TAPP) repair. We divided the patients into a training set (n = 188) and a validation set (n = 78). We employed logistic regression to identify independent risk factors for post-TAPP seroma and developed a nomogram to predict the occurrence of seromas. The model’s accuracy was evaluated using receiver operating characteristic (ROC) curves, Hosmer-Lemeshow goodness-of-fit test, calibration curves, and decision curve analysis (DCA). Results Postoperatively, 20.3% of patients developed a seroma. Multivariate logistic regression analysis highlighted several independent risk factors for seroma formation: the use of anticoagulants, an internal ring defect ≥5 cm, scrotal hernia, incarcerated hernia, and transected hernia sac ( P < 0.05). The ROC curves for the training and validation sets demonstrated areas under the curve of 0.893 (95% CI: 0.845-0.942) and 0.864 (95% CI: 0.765-0.963), respectively, indicating good model fits ( P > 0.05). DCA confirmed significant clinical applicability of the model. Conclusion The findings suggest that the use of anticoagulants, an internal ring defect ≥5 cm, scrotal hernia, incarcerated hernia, and transected hernia sac are significant independent risk factors for seroma formation after TAPP repair. Clinical consideration of these factors and proactive preventive measures are essential. Although many of these factors are non-modifiable, understanding them is crucial for preoperative risk assessment and patient management.
In Search of Deliberate Practice: Simulating Teaching in Three Teacher Education Programs
Authors: Wilson Kristyn , Yonas Anna M. 
Published: November 2024

Background: Mixed reality simulations (MRSs) offer a platform for novice teachers to practice teaching in the absence of real children. Though prior research suggests simulated practice can be beneficial for novice teachers, these studies describe widely varying designs and implementations across teacher education programs (TEPs). As such, we lack clarity about the relative benefits of different approaches to simulated practice for novices who are entering teaching via a growing array of pathways. Purpose: To better understand the influence of context on novice teachers’ experiences in simulations, we conducted a study of three teacher education programs that used simulations as a component of their teacher education curriculum. Specifically, we asked the following research questions: How do novices in three differently structured TEPs experience a series of parallel practice opportunities in MRSs? What contextual features into, through, and beyond the approximation contribute to variation, if any, in novices’ experiences of practice in MRSs? Research Design: This mixed methods study leverages postsimulation survey data from novices ( n = 160) in three TEPs to understand how they experienced a parallel series of simulation tasks paired with support in the form of coaching or self-reflection. We elaborate on survey findings with qualitative analysis of each teacher education program and interviews with a purposive sample of participants from each program ( n = 15). Conclusions: Findings highlight the influence of context and supports on novices’ simulation experiences. In particular, the sequencing of practice with other preparatory opportunities into and beyond the approximation, as well as the provision of feedback and level of challenge through the practice can promote more useful practice opportunities in teacher education.
The Effect of Emotional Coworker Support on Work Engagement Among Pediatric Health Care Providers: The Mediator Role of Emotional Regulation
Authors: Dal Santo Letizia , Michaux Robin , Pohl Sabine 
Published: November 2024

Background: Previous findings demonstrated that healthcare workers with a high level of social support are likely to engage in their work. Healthcare workers are not only engaged in the physical problems of their patients but also in their emotional difficulties. Pediatric professionals must express and regulate their own emotions during their interactions with young patients and their families. Purpose: The purpose of this study was to explore the impact of coworkers’ emotional support on healthcare workers’ work engagement in pediatric healthcare settings and the emotional regulation mechanisms by which emotional coworker support leads to work engagement. Method: A cross-sectional study was distributed in a Belgian pediatric hospital between October 2021 and December 2021. The sample consisted of 274 healthcare workers who were in direct contact with patients. Participants completed a questionnaire consisting of measures of coworker emotional support, work engagement, emotional suppression, and cognitive reevaluation. Results: Emotional suppression partially mediated the effects of perceived emotional coworker support on work engagement. Coworkers’ emotional support fosters work engagement by reducing the negative effects of emotional suppression. Moreover, cognitive evaluation was positively associated with work engagement. Conclusions: These results provide insight into the influence of perceived emotional coworkers, emotional suppression, and cognitive reevaluation on work engagement.
Pulse Wave Doppler Ultrasound in Unmasking of Venous Obstructions Highlighting Diagnostic Utility and Clinical Implications
Authors: Usman Shaheryar , Cheema Muhammad , Mustafa Saleem , Khan Muhammad Jahanzaib , Kulkarni Siddhant , D’Angelo Katelyn , Felicio Anthony , Iftikhar Asma 
Published: November 2024

Venous obstructions and thrombosis can present diagnostic challenges due to their varied presentations and potential for significant complications if untreated. Pulse wave doppler ultrasound via identification of damping or loss of cardiac pulsatility and/ or respiratory phasicity of venous waveforms serves as a practical, noninvasive, fast, and efficient diagnostic tool for identifying venous obstructions in the presence of compressible veins beyond the point of evaluation. We present two cases demonstrating the effectiveness of pulse wave doppler ultrasound in identifying significant and life-threatening venous obstructions. The first case involves a 68-year-old male with an incidental finding of a compressible left subclavian vein showing a monophasic waveform. Further investigation revealed significant compression of the left brachiocephalic vein by an aortic arch aneurysm. The second case describes a 65-year-old male with a compressible right femoral vein but a monophasic waveform, leading to the discovery of extensive thrombosis from the iliac veins to the inferior vena cava. This series proposes to always assess cardiac pulsatility and respiratory phasicity during doppler ultrasound procedure such as thyroid ultrasounds, deep vein thrombosis (DVT) evaluations, and pre-central vein catheterizations for identifying any venous obstructions, whether they are intrinsic or extrinsic, and for reducing the risk of thromboembolic complications.
Recalcitrant Torticollis: A Formidable Treatment Challenge
Authors: Daly Gwendolyn E. , Otto Madeline , Alturky Sara , Balumuka Darius , Isbester Kelsey , Stefanik Fiona , Sjostrand Gregory , Howell Lori K. , Wolfswinkel Erik M. 
Published: November 2024

Introduction There are few evidence-based practice guidelines for recalcitrant torticollis (RT), defined as torticollis that persists past 1 year of age despite conservative therapy. Available evidence recommends a combination of physical therapy (PT), occupational therapy (OT), botulinum toxin injection (BTI), and in the most severe cases, surgical release. Methods This is a single-center, retrospective study conducted with Institutional Review Board approval. Inclusion criteria were diagnosis of congenital muscular torticollis before 1 year old and persistence of symptoms past 1 year despite conservative treatment between January 1, 2005, and January 30, 2023. Patients with incomplete data, acquired torticollis, confounding diagnoses, or who did not receive a diagnosis or conservative therapy before 1 year of age were excluded. Results Seventy-seven patients met the inclusion criteria. The average age at diagnosis was 4.5 ± 2.5 months. Initial treatment consisted of PT for 61 patients (79.2%), stretching exercises for 11 patients (14.3%), and OT for 4 patients (5.2%). Regardless of timing, 74 patients in total (96.1%) received PT for an average of 13.3 ± 8.6 months. Conservative treatment modalities led to the resolution of symptoms for 40 patients (51.2%) and improvement of symptoms for 35 patients (45.5%). Two patients received at least 1 BTI which led to further improvement of symptoms. One patient underwent operative intervention which consisted of sternocleidomastoid release. Conclusions RT is a challenging clinical entity that requires diligent multidisciplinary care. Patients who present and begin conservative therapy before 1 year of age are likely to have improvement or resolution of symptoms without more advanced therapies.
Enhanced Prenatal and Postnatal Development Study in Marmoset Monkeys Following Administration of Felzartamab
Authors: Mangelberger-Eberl Doris , Cosenza Mary Ellen , Härtle Stefan , Luetjens C. Marc , Welsh Brian T. , Steidl Stefan , Flesher Donna L. , Chinn Leslie W. 
Published: November 2024

Felzartamab is a recombinant fully human immunoglobulin G1 anti-CD38 monoclonal antibody under clinical investigation for immune-mediated diseases. In support of felzartamab clinical development, toxicology studies were conducted in marmoset monkeys, which was the most relevant species based on CD38 binding affinity, pharmacologic activity, and target expression. The felzartamab toxicology program included an enhanced prenatal and postnatal development (ePPND) study to identify potential reproductive and postnatal development risks. In this ePPND study, pregnant marmoset monkeys were randomized to receive vehicle (0 mg/kg) or felzartamab at two dose levels (15 mg/kg and 75 mg/kg) twice per week until parturition, and maternal animals and infants were evaluated for 6 months thereafter. Felzartamab exposure was confirmed in maternal animals and infants in both dosing groups. Overall, felzartamab was well tolerated by pregnant animals at the evaluated doses, with no effect on body weight or body weight gain during pregnancy. No felzartamab-related effects on pregnancy loss or stillbirth rate were observed, and litter counts and numbers of liveborn infants were similar between the vehicle and felzartamab groups. Among infants, there were no felzartamab-related malformations or variations in external anatomy or skeletal morphology and no felzartamab-related observations in histopathology, hematologic and immune cell development, or humoral immune response to vaccination. In conclusion, among pregnant marmoset monkeys dosed with felzartamab, the lack of reproductive toxicity and felzartamab-related effects on offspring supports the clinical evaluation of felzartamab in women of childbearing potential and further demonstrates the suitability of the marmoset monkey for ePPND studies.