bluuebunny/crossref_metadata_2025_split huggingface dataset:
Only extremely high peak serum estradiol adversely affects endometrial receptivity in IVF treatment
Authors: Song Jianyuan , Liao Tingting , Jiang Liu , Su Houming , Ji Licheng , Lai Youhua , Zhu Guijin , Jin Lei , Qian Kun 
Published: September 2019

Abstract
Purpose To explore the effect of different concentrations of peak serum estradiol levels on endometrial receptivity quantitatively.
Methods In our reproductive medicine center, two best quality of day 3 (D3) embryos were transferred or frozen according to E 2 and progesterone levels on the day of human chorionic gonadotropin (hCG) administration and the number of oocytes retrieved. The remaining embryos were cultured to blastocyst stage and frozen. The patients were then categorized into three groups. The patients with frozen-thawed D3 embryo transfer in artificial cycles without blastocyst frozen served as group 1, those with fresh D3 embryo transfer without blastocyst frozen as group 2, and those with fresh D3 embryo transfer with blastocyst frozen as group 3. Each group was further stratified into 4 sub-groups according to E 2 levels on the day of hCG administration. Clinical pregnancy rate, implantation rate and abortion rate of frozen-thawed and fresh D3 embryo transfer were compared among the three groups in the same stratified E 2 levels.
Results For E 2 <7,000 pg/mL, group 1 and group 2 had similar clinical pregnancy rate and implantation rate. But for E 2 ≥7,000 pg/mL, the clinical pregnancy rate in group 1 was significantly higher than in group 2 (p<0.05). For E 2 <7,000 pg/mL, pregnancy rate and implantation rate in group 1 were significantly lower than those in group 3 (P<0.05). But for E 2 ≥7,000 pg/mL, the pregnancy rate in group 1 was significantly higher than in group 3 (P<0.05). There was no significant difference in the abortion rate between group 1 and group 2, or between group 1 and group 3.
Conclusions High serum E 2 concentration does not impair implantation and pregnancy rates unless exceeding a certain limit (e.g. 7,000 pg/mL) on the day of hCG administration. Since peak E 2 level was related to OHSS and adverse pregnancy outcomes, further study is needed to set a threshold peak E 2 level for fresh embryo transfer.
Pediatric Brain tumors in Southeast Nigeria; An 8-year prospective longitudinal cohort study
Authors: Uche Enoch , Uche Nkechi Judith , Ajuzieogu Obinna V , Amuta Dubem , Onyia ephraim , Eke Chris , Okafor John , Emejulu John-Kennedy , Mezue Wilfred , Ryttlefors Matt , Tisell Magnus 
Published: September 2019

Abstract
Background: Pediatric brain tumors (PBT’s) from previous studies are associated with poor outcomes in our subregion. Methods. An 8 -year single center prospective study. All cases investigated with neuroimaging and treated were enrolled. Data was analyzed with SPSS (Inc) Chicago IL, USA version 23. Chi Square test, One-way Anova and confidence limits were used to evaluate associations using the 95% level of significance. Patients were followed up for a range of 1 to 7.5 years with a mean of 4.9 ±1.3years. Ethical approval was obtained for our study. Results: 95 patients were enrolled, 84 satisfied the study criteria. There were 45 males and 39 females, M: F=1.1. The mean age was 9.9±2.7 years 95%CI with a range of 9 months to 16 years. The most common symptom was headache for supratentorial lesions (73%) and gait disturbance (80.2%) for infratentorial lesions. More tumors were supratentorial in location (45(54.2%), while 33(37.1%) were infratentorial. Craniopharyngiomas (n=19), medulloblastomas(n=17) and astrocytomas (n=11) were the most common tumors. Hemoglobin genotype(AA and AS) had some influence on tumor phenotype, Odds ratio 8.9 and 3.3 for medulloblastoma and craniopharyngioma. 69 cases were microsurgically resected while 14 patients were treated with radiotherapy alone. The 30-day mortality for operated cases is 7.9±1.3%. Overall 1-year and 5-year survival was 67.9% and 53.6 % respectively. Survival rates varied among treatment groups (X2=8.9, P=0.017). Conclusion: Survival profile in this series suggests some improvement in comparison to previous studies from our region.
Comparison of household expenditure between urban slum and non-slum dwellers in a Southwestern metropolis, Nigeria
Authors: Obembe Taiwo A , Levin Jonathan , Fonn Sharon 
Published: September 2019

Abstract
[EXSCINDED] Abstract Background The growth of urban slums has become a source of global concern due to the less-than-optimal conditions in which they exist. Of particular interest here, are the spending patterns of slum inhabitants in order to understand where funds are diverted from when a sudden health challenge occurs. This study sought to provide baseline statistics of household expenditure patterns of selected slums dwellers in southwestern Nigeria using non-slums dwellers as a comparison group.Methods The study utilised a retrospective descriptive cross-sectional design involving 450 respondents from both slums and non-slums. Information pertaining to spending patterns was collected using semi-structured questionnaires (adapted from the World Health Survey) and cost diaries. Results are presented as weighted means and weighted percentages.Results A total of 239 participants were slum dwellers while 211 were non-slum dwellers. Mean age of slum dwellers was 38years (95% CI: 35 – 42 years) while non-slum dwellers had a mean age of 39 years (95% CI: 36 - 41). Mean monthly income for slum dwellers was N93,118; 95%CI: N66,106 – N120,130 while that of non-slum dwellers was N269,700; 95%CI: N209,312 – N330,227. Mean monthly expenditure of N 21,335 was spent on food among the slum dwellers and N 25,131 among the non-slum dwellers. Both slum dwellers and non-slum dwellers spent a large proportion of their monthly income on food, rent, education and health care.Conclusion The earning capacity (income) of respondents from the slums is low compared to the non-slum counterparts. Money allocated to specific and basic household items account for major portions of the slum dwellers’ income, thus they are less likely to be prepared to deal with costs of a medical emergency (compared to non-slum dwellers). Concerted efforts are needed to provide more jobs or empowerment schemes that can alleviate the burden of poverty in the slums and improve their living conditions also.
The Association Between the Severity of the Mandibular Inferior Cortex Porosity and the Number of Remaining Teeth in Elderly Indonesian People
Authors: Kiswanjaya Bramma , Bachtiar-Iskandar Hanna H 
Published: September 2019

Abstract
Background The purpose of this study was to investigate the association between the severity of the mandibular inferior cortex (MIC) porosity and the number of remaining teeth in elderly Indonesian people.Materials and methods This cross-sectional study was conducted by measuring secondary data on panoramic digital examinations of patients aged 50 years and older. A total of 428 panoramic radiographs were measured from January 2017 to December 2018. The number of remaining teeth (including the third molars) was evaluated. Mandibular porosity was measured by using panoramic radiographs, according to the MIC classification: normal; mildly to moderately eroded; and severely eroded cortex.Statistical analysis used Data analysis was done using Mann-Whitney nonparametric tests to verify the relationship between the MIC classification and the number of remaining teeth. Multiple linear regression analysis was performed to investigate the relationship between confounding variables.Results A significant correlation was found between MIC classification and the number of remaining teeth on the Mann-Whitney test (P < 0.001). Multiple linear regression analysis showed that MIC classification was significantly associated with the value of the number of remaining teeth after controlling for gender and age (β = -0.37, R2 = 0.22, P < 0.001). Subjects with MIC class 3 were 7.14 times more likely to lose their teeth than subjects with MIC class 1 or class 2.Conclusions Our study demonstrated that there was an association between the severity of mandibular inferior cortex porosity and the number of remaining teeth in elderly Indonesian people.
Proteins encoded by Novel ORFs have increased disorder but can be biochemically regulated and harbour pathogenic mutations
Authors: Jagannathan N. Suhas , Meena Narendra , Bhayankaram Kethaki Prathivadi , Prabakaran Sudhakaran 
Published: September 2019

Abstract
Recent advances in proteogenomics indicate that protein or protein-like products can be encoded by previously uncharacterized Open Reading Frames (ORFs) that we define as Novel Open Reading Frames (nORFs)1​ ​,2​ ​. Although it is yet unclear if these protein or protein-like products could possess any significant biological function hopes have been raised to target them for anticancer and antimicrobial therapy 3​ ,4​. In this study, we used computational tools to systematically investigate these novel protein sequences for their propensities toward structural disorder, post-translational modifications (PTM) and mutational densities. We found that these novel proteins have significantly higher disorder and similar PTM frequencies compared to known proteins. Although these regions were found to harbour deleterious mutations, we did not observe any correlation between the pathogenicity of mutations and their location (ordered/disordered) within these novel proteins. This study suggests that these nORFs encode an important class of proteins, that could undergo sequence, structural or regulatory changes during complex diseases, and hence warrant further study.
Estatísticas e Políticas Públicas orientadas por evidências no Brasil: o caso das Políticas de Desenvolvimento Social nos anos 2000
Authors: Jannuzzi Paulo de Martino 
Published: September 2019

A tese central deste texto é mostrar como a produção regular e a ampla disponibilidade de Estatísticas Públicas, em particular, dos Indicadores Sociais construídos a partir da Pesquisa Nacional por Amostra de Domicílios (PNAD), cumpriram papeis importantes na agenda de combate à fome e na Política de Desenvolvimento Social no país, ao aportar insumos para defesa da sua relevância, desenho, monitoramento e avaliação dos seus programas. Inicia-se com uma recensão sobre o surgimento dos Indicadores Sociais em meio à estruturação do Estado de Bem-Estar ao longo do século XX. Em seguida, apresenta-se como a PNAD foi se transformando em uma pesquisa com escopo temático cada vez mais amplo e aderente às preocupações do Estado e Sociedade brasileiros, e como as informações levantadas na pesquisa foram sendo empregadas na Política de Desenvolvimento Social e seus programas no país. À guisa de conclusão, advoga-se pela necessidade de uso mais bem informado e plural das estatísticas pela mídia brasileira, pelos riscos de crescente deslegitimação de políticas e programas constituintes da trilha civilizatória inscrita na Constituição Federal de 1988.
Addressing water-related shocks and coping decision through enhanced community participation: case studies from Ganga basin, Uttarakhand, India
Authors: Sharma Divya , Khandekar Neha , Sachdeva Kamna 
Published: September 2019

Abstract
Farming communities in the Upper Ganga basin, nestled in the Himalayan region, are finding it extremely difficult to face water-related shocks, which stand to profoundly impact their quality of life and livelihoods, due to climate change. Often, coping strategies (technological or institutional interventions), developed by planners, become counter-productive as they are not in cognizance with the end user community. This study presents a methodology to enable incorporation of community knowledge and expectations in planning by integrating participatory rural appraisal (PRA) with geographic information systems, leading to better informed coping strategies. As part of this, we create thematic maps which: (i) capture information on a spatial scale (otherwise lost during PRA), (ii) facilitate community participation for further research and planning in their contexts, and, (iii) co-create knowledge to develop a shared understanding of water-related hazards at the village level. The proposed methodology is presented through three case study sites – two in the plains (&lt;500 masl) and one in the middle (500–1,500 masl) elevation regions of Upper Ganga basin. We show how this way of approaching context analysis facilitates community involvement as well as co-creating a knowledge base which can help researchers and government officials with mindful planning of interventions in the area.
Role of TREM2 in Alzheimer's Disease and its Consequences on β- Amyloid, Tau and Neurofibrillary Tangles
Authors: Singh Anurag K. , Mishra Gaurav , Maurya Anand , Awasthi Rajendra , Kumari Komal , Thakur Abhimanyu , Rai Arati , Rai Gopal Kumar , Sharma Bhupesh , Kulkarni Giriraj T , Singh Santosh Kumar 
Published: September 2019

:
Alzheimer's Disease (AD) is age-related neurodegenerative disorder recognized by a steadily
gradual cognitive decline that has devastating personal and socioeconomic implications. Recently, some
genetic factors for AD have been identified which attracted wide attention of researchers in different
areas of AD biology and possible new therapeutic targets. Alternative forms of triggering receptor expressed
on myeloid cells 2 (TREM2) genes are examples of such risk factors, which contribute higher
risk for developing AD. Comprehending TREM2 function pledge to provide salient insight into how
neuroinflammation contributes to AD pathology. The dearth of microglial TREM2 shepherd to augmented
tau pathology is couple with frequent enhancement of activated neuronal stress kinases. The involvement
of TREM2 in the regulation of tau-associated innate immune response of the CNS has clearly
demonstrated through these findings. However, whether decrease level of TREM2 assists pathology of
tau through changed clearance and pathological escalation of tau or through direct contact between microglia
and neuron and any alternative possible mechanisms need to examine. This review briefly summarizes
distinct functional roles of TREM2 in AD pathology and highlights the TREM2 gene regulation.
We have also addressed the impact of TREM2 on β-amyloid plaques and tau pathology in Alzheimer’s
disease.
Overview of Current Immunotherapies Targeting Mutated KRAS Cancers
Authors: Hoo Winfrey Pui Yee , Siak Pui Yan , In Lionel L.A. 
Published: September 2019

:The occurrence of somatic substitution mutations of the KRAS proto-oncogene is highly prevalent in certain cancer types, which often leads to constant activation of proliferative pathways and subsequent neoplastic transformation. It is often seen as a gateway mutation in carcinogenesis and has been commonly deemed as a predictive biomarker for poor prognosis and relapse when conventional chemotherapeutics are employed. Additionally, its mutational status also renders EGFR targeted therapies ineffective owing to its downstream location. Efforts to discover new approaches targeting this menacing culprit have been ongoing for years without much success, and with incidences of KRAS positive cancer patients being on the rise, researchers are now turning towards immunotherapies as the way forward. In this scoping review, recent immunotherapeutic developments and advances in both preclinical and clinical studies targeting K-ras directly or indirectly via its downstream signal transduction machinery will be discussed. Additionally, some of the challenges and limitations of various K-ras targeting immunotherapeutic approaches such as vaccines, adoptive T cell therapies, and checkpoint inhibitors against KRAS positive cancers will be deliberated.
Predicting LncRNA Subcellular Localization Using Unbalanced Pseudo-k Nucleotide Compositions
Authors: Yang Xiao-Fei , Zhou Yuan-Ke , Zhang Lin , Gao Yang , Du Pu-Feng 
Published: September 2019

Background:
Long non-coding RNAs (lncRNAs) are transcripts with a length more
than 200 nucleotides, functioning in the regulation of gene expression. More evidence has shown
that the biological functions of lncRNAs are intimately related to their subcellular localizations.
Therefore, it is very important to confirm the lncRNA subcellular localization.

Methods:
In this paper, we proposed a novel method to predict the subcellular localization of
lncRNAs. To more comprehensively utilize lncRNA sequence information, we exploited both kmer
nucleotide composition and sequence order correlated factors of lncRNA to formulate
lncRNA sequences. Meanwhile, a feature selection technique which was based on the Analysis Of
Variance (ANOVA) was applied to obtain the optimal feature subset. Finally, we used the support
vector machine (SVM) to perform the prediction.

Results:
The AUC value of the proposed method can reach 0.9695, which indicated the proposed
predictor is an efficient and reliable tool for determining lncRNA subcellular localization. Furthermore,
the predictor can reach the maximum overall accuracy of 90.37% in leave-one-out cross
validation, which clearly outperforms the existing state-of- the-art method.

Conclusion:
It is demonstrated that the proposed predictor is feasible and powerful for the prediction
of lncRNA subcellular. To facilitate subsequent genetic sequence research, we shared the
source code at https://github.com/NicoleYXF/lncRNA.
Perundungan dan School Well-being: Place Attachment sebagai Moderator
Authors: Astuti Katarina Menik , Djuwita Ratna 
Published: September 2019

Abstrak. Salah satu bentuk perilaku yang dapat menurunkan school well being dan membuat iklim sekolah menjadi tidak menyenangkan adalah perundungan. Studi literatur menunjukkan bahwa selain perundungan, place attachment terhadap sekolah ternyata juga mempengaruhi school well being. Peneliti mengajukan hipotesis bahwa place attachment berperan sebagai moderator dalam hubungan antara perundungan dan school well being. Pengambilan data dilakukan pada 133 orang mahasiswa tingkat pertama dengan menggunakan kuesioner yang mengadaptasi alat ukur school well-being dan place attachment. Selain itu ditanyakan pula pengalaman perundungan responden saat di SMA. Hasil penelitian membuktikan bahwa place attachment berperan sebagai moderator dalam hubungan antara perundungan dengan school well-being; semakin tinggi place attachment maka semakin kuat hubungan negatif antara perundungan dengan school well-being. Hal ini menunjukkan bahwa place attachment dapat menjadi penangkal terhadap perundungan. Bagi siswa yang memiliki ikatan dan identifikasi diri yang kuat terhadap sekolah, maka perundungan yang terjadi tidak menurunkan school well-beingnya. Mereka akan tetap merasa nyaman bersekolah walaupun perundungan masih terjadi.Kata kunci: Perundungan, Place Attachment, School Well-being, ModeratorAbstract. One form of behavior that can reduce school well-being and make unpleasant school climate is bullying. Literature studies shows, that besides bullying, place attachment to school also affects school well being. The researcher hypothesized that place attachment acts as a moderator in the relationship between bullying and school well being. Data collection was conducted on 133 first-degree students using a questionnaire adapting the school well-being and place attachment questionnaire. In addition, the questionnaire also asked about respondents' bullying experience when in high school. The results show that place attachment acts as a moderator in the relationship between bullying with school well-being: Higher place attachment will act as a buffer on bullying. Students who have strong bonds and identify themself strongly with their schools, their school well-being will not be harmed by bullying. This suggests that students with high place attachment can remain comfortable and happy in school, even though bullying still occurs in their schools.Keywords: Bullying, Moderation, Place Attachment, School Well-being
Implementasi pendidikan seks berbasis sekolah
Authors: Maimunah Siti 
Published: September 2019

Abstrak. Penelitian ini bertujuan untuk menerapkan model pendidikan seks di sekolah. Subjek yang terlibat dalam penelitian ini terdiri dari 6 guru dan 60 siswa yang telah dipilih berdasarkan kriteria khusus yang telah ditetapkan dan mereka bersedia mengikuti program dari awal hingga selesai. Desain penelitian yang digunakan dalam penelitian ini adalah one group pretest posttest design. Hasil penelitian menunjukkan bahwa program ini mampu meningkatkan pengetahuan dan keterampilan guru-guru dalam mengajarkan materi pendidikan seks. Hal ini ditunjukkan dengan nilai mean sebelum dilakukan intervensi adalah 4, 17 dan setelah pelaksanaan adalah 22,33 dan nilai r sebesar -0,878 dan nilai t sebesar -27,776. Pada siswa, program ini juga terbukti efektif dalam meningkatkan pengetahuan siswa, merubah sikap terhadap seks pranikah dan mengurangi intensi untuk terlibat dalam perilaku seks pranikahKata Kunci : Pengetahuan, Pendidikan Seks, Remaja Abstract. This study aims to apply the model of sex education in schools. The subjects involved in this study consisted of 6 teachers and 60 students who had been selected based on specific criteria set and they were willing to take the program from start to finish. The research design used in this study is one group pretest posttest design. The results showed that this program was able to improve the knowledge and skills of teachers in teaching sex education material. This is indicated by the mean value before intervention is 4, 17 and after implementation is 22.33 and the r value is -0.887 and the t value is -27.776. For students, this program has also proven effective in increasing student knowledge, changing attitudes towards premarital sex and reducing the intention to engage in premarital sexual behavior.Keywords: Adolescent, Knowledge, Sex education
...retrato de un momento
Authors: Venegas Romero Pablo 
Published: September 2019

La editorial no es solamente un espacio que de cuenta de lo que en el número se ha publicado, también es un lugar de opinión y de reflexión, en torno al core de la revista pero además a la contingencia. Desde este número, el equipo editorial se ha renovado y así es como se incorporarán nuevos objetivos y tareas que permitan mejorar la performance y al menos mantener el estado de reconocimiento que tiene Panambí hasta hoy; su prestigio.Agradecemos a quienes dejan sus labores y esperamos poder (quienes nos integramos) realizar la tarea con el mismo profesionalismo con el que hasta ahora se ha desarrollado.