bluuebunny/crossref_metadata_2025_split huggingface dataset:
Glucosa 6 fosfato deshidrogenasa: características bioquímicas y moleculares. Prevalencia de la deficiencia
Authors: Bastidas Pacheco Gilberto Antonio , Pérez Hilda , Vizzi Esmeralda 
Published: May 2019

La glucosa-6-fosfato deshidrogenasa (G6PD) es una enzima citoplasmática que se encuentra distribuida en todas las células del organismo y que cataliza el primer paso de la vía de las pentosas en el cual la glucosa 6 fosfato (G6P) es convertida a 6-fosfogluconato (6FG) y el NADP reducido a NADPH, proceso indispensable para proteger a los eritrocitos del daño oxidativo. La deficiencia de la enzima G6PD es la eritroenzimopatía más común, es recesiva y ligada al cromosoma X, con amplia distribución mundial y elevada heterogeneidad genética y bioquímica. Se realizó una revisión sobre aspectos bioquímicos, estructura, genética, bases moleculares, defecto enzimático, prevalencia de la deficiencia en el mundo y en Venezuela, y el papel de la deficiencia de G6PD en el tratamiento de la malaria por el incremento en el riesgo de hemolisis que lleva consigo la tendencia de aumentar la dosis total de Primaquina en sujetos paludismo, particularmente en las regiones donde predomina la infección por Plasmodium vivax.
Diagnóstico de Simulación de Disfunción Neurocognitiva en sujetos que presentan accidentes laborales
Authors: Puerta Lopera Isabel C , Arango Tobon Eduardo , Betancur Arias Juan Diego , Sanchez Duque Jose Wilmar 
Published: May 2019

Objetivo: Establecer la utilidad del Test de Simulación de la Memoria (TOMM) y las características psicométricas para determinar la Simulación de Disfunción Neurocognitiva (SND) en trabajadores que han sufrido Traumatismo Cráneo-Encefálico (TEC). Materiales y métodos: Los participantes de esta investigación fueron por conveniencia. Se conformaron tres grupos no pareados, mayores de 18 años, de ambos sexos. El primer grupo se conformó con un total de 32 participantes que estuvieron activamente laborales antes de sufrir el TEC, mínimamente 6 meses antes de la evaluación. El segundo grupo estuvo conformado por 30 personas que ya se encontraban pensionados laboralmente y no poseían necesidades de SDN. El último grupo eran 31 participantes cognitivamente sanos, que voluntariamente desearon participar en el estudio. Resultados: El TOMM es capaz de diferenciar entre aquellas personas probables de tener SDN y de las que no lo tienen. Aplicando el punto de corte de 45 para el ensayo 2, el 92.04% de los participantes controles (81/88 participantes) y 5 de los 5 simuladores (100%) fueron correctamente identificados, lo que corresponde a una sensibilidad del 100% y una especificidad del 92%, es decir la probabilidad de clasificar correctamente a un individuo como simulador, siendo éste un real simulador es del 100%, sin embargo la probabilidad de clasificar a un individuo como simulador, sin realmente serlo, es del 8%. Conclusiones: El TOMM es una herramienta clínica de exploración que permite distinguir entre los sujetos que posiblemente presenten necesidad de obtención de ganancias secundarias a un accidente laboral.
Adherencia a los antidepresivos: reto terapéutico para mejores desenlaces clínicos en pacientes con depresión.
Authors: Urrego Vásquez Andrea , Gaviria García Juan Ricardo , Martínez Dominguez Gloria Inés , Martínez Sánchez Lina María , Ospina Sánchez Juan Pablo 
Published: May 2019

La depresión es una enfermedad psiquiátrica que se manifiesta a través de un estado de ánimo bajo y síntomas somáticos como debilidad, trastornos del sueño, entre otros. Se presenta en edades tempranas principalmente, sin embargo se ha descrito en cualquier grupo etario; esta enfermedad genera alto impacto en el entorno familiar, social y laboral de la persona. La terapia antidepresiva comprende tanto el tratamiento farmacológico como las psicoterapias, siendo ambas el pilar fundamental para la remisión de esta patología. Por lo tanto, la adherencia terapéutica, definida como el cumplimiento de las dosis y tiempos indicados del medicamento prescrito y la aceptación de los cambios en el estilo de vida, se considera un reto clínico que a pesar de ser poco estudiado, se ha visto que mejora considerablemente el control de los síntomas depresivos y evitando consecuencias como la discapacidad.
STRATEGY OF INFUSION-TRANSFUSION THERAPY IN OPERATIONS WITH MASSIVE BLOODWORK IN CHILDREN WITH TUMOR ABOMALOMAL LOCALIZATION TUMORS
Authors: Belousova E. I. , Matinyan N. V. , Martynov L. А. 
Published: May 2019

Surgeries for thoracoabdominal tumors in children predispose to water and electrolyte imbalance, imbalance in the coagulation system, etc. In spite of abundance of recommendations for children, the volume of basic infusion therapy is uncertain.Study purpose. To estimate the clinical effectiveness of the conducted infusion therapy with isotonic balanced electrolyte solution in children who underwent thoracoabdominal surgeries accompanied with massive blood loss and a complex estimation of the conducted infusion and transfusion therapy.Materials and methods. The intraoperative and early postoperative (days 1–5) periods were analyzed in 22 patients (ASA II–III) who underwent an operation for thoracoabdominal malignant tumors with massive perioperative blood loss in 2016–2017. Group I included 11 patients who had infusion with balanced crystalloid solutions of 5 to 10 ml/kg/hour under combined anesthesia. Group II includes 11 patients who had infusion with balanced crystalloid solutions of 11 to 20 ml/kg/hour under combined anesthesia.Results. According to the conducted study, a higher hemodynamic stability was observed in patients from the group of basic infusion therapy with balanced crystalloid solutions of 11–20 ml/kg/hour. It was expressed as the decrease of the mean dose of the used vasopressors and volume of the infusion of colloidal solutions. The patients also had a less intense response to stress.
THORACOSCOPIC POSTERIOR TRACHEOPEXIE IN A NEWBORN WITH TRACHEOMALACIA AND ESOPHAGEAL ATRESIA
Authors: Kozlov Yu. A. , Rasputin A. A. , Kovalkov K. A. , Baradieva P. J. , Ochirov Ch. B. 
Published: May 2019

Introduction. Esophageal atresia is often accompanied by some form of tracheomalacia. Soon after birth, tracheal collapse can result in respiratory disturbances of various degrees – from mild to severe – requiring artifcial pulmonary ventilation. In this study, we describe the use of a new treatment method of tracheomalacia with posterior tracheopexie.Material and methods. A patient with tracheomalacia that developed against the background of esophageal atresia was presented in the study. A newborn boy of 2,720 g had a prenatally established diagnosis of esophageal atresia. The infant was born with the signs of respiratory disturbances. Following tracheoscopy, severe tracheomalacia was established with complete collapse of tracheal lumen. During the next thoracoscopic procedure, the trachea was fxed to the anterior longitudinal spinal ligament with several sutures.Results. Thoracoscopic posterior tracheopexie was performed prior to esophageal anastomosis. Overall duration of surgery was 85 minutes. Spontaneous breathing was restored at day 3 after the surgery. Tracheoscopy performed at day 10 after the surgery demonstrated a complete opening of the tracheal lumen.Conclusion. Promising results of the surgery prove that the procedure is eﬀective for the treatment of tracheomalacia. Moreover, more complex (aortopexy) recurrent surgeries can be prevented using this approach as posterior tracheopexie can be performed during the primary thoracoscopic correction of esophageal atresia.
SUCCESSFUL SURGICAL TREATMENT OF A NEWBORN WITH CHYLOPERITONEUM
Authors: Kucherov Yu. I. , Kholodnova N. V. , Adleiba S. R. , Belaya A. L. , Makarova L. M. , Ovsiannikova M. A. , Zhirkova Yu. V. 
Published: May 2019

The article describes clinical observation of treatment of a premature infant with chyloperitoneum. Accumulation of fluid in the abdominal cavity was diagnosed prenatally at 31–32 weeks of gestation. Premature surgical delivery was performed at 34– 35 weeks due to the high risk of antenatal fetal death. Paracentesis with fluid analysis was done; chylous exudate was confirmed. Total parenteral nutrition, octreotide and drainage of the abdominal cavity were used during conservative treatment. It was decided to perform a surgery as the therapy was ineffective. At the age of 2 months and 7 days laparotomy was conducted, abdominal organs were revised, lymph ducts were ligated, and abdominal cavity was drained producing a positive effect. The fluid outflow was terminated and the child was discharged in a satisfactory condition.
Diagnostic role of bronchoalveolar lavage: A cytohistopathological correlation
Authors: Choudhary Prabesh Kumar , Nepal Niraj , Mainali Nirajan , Ghimire Ram Hari 
Published: May 2019

Background: Tumors of lung are common in Nepal. The risk of malignancy has to be judged prior to surgery for which bronchoscopy is often done. Brocho-alveolar lavage and bronchial biopsy are routine procedure done for diagnosis of lung cancer during bronchoscopy. This study was done to correlate the cytology of broncho-alveolar lavage specimen with histopathology in malignant tumors of the lug in our setup.
Materials and methods: This study was conducted at department of pathology, Nobel Medical College from August 2017 to December 2018. Histopathology reports with malignancy were compared to their cytological diagnosis.
Results: A total of 141 cases were included in the study. Among the study population, Bronchogenic carcinoma was found more prevalent in female. The sensitivity, specificity, positive predictive value, negative predictive value and overall accuracy of broncho-alveolar lavage in the diagnosis of lung cancer were 88.1%, 97.98%, 94.7%, 95.1% and 95.03% respectively.
Conclusions: Brochoalveolar lavage cytology has a greater accuracy for the diagnosis of lung cancer; however, benign cases need regular follow up as there are false negative cases.
Antibiotic sensitivity pattern in culture positive typhoid fever cases isolated at Patan hospital
Authors: Shrestha Sanjay Kumar , Basnet Shova 
Published: May 2019

Background: Enteric fever is one of the most common systemic infections of developing countries like Nepal. The changing trend of antibiotic susceptibility and increasing rate of resistance to the commonly used antibiotics has been of great concern in the proper treatment and prevention of this disease. This study aims to investigate the current antibiotic susceptibility pattern of Salmonella typhi and paratyphi A and B.
Materials and Methods: This study was carried out at Patan hospital of Lalitpur, Nepal from ____ to -------. Blood culture sample were collected from suspected patients presenting to different departments of the hospital and tested microbiologically by standard procedure. Antibiotic susceptibility test was performed by Kirby Bauer Disc Diffusion method and results were interpreted by National Committee for Clinical Laboratory (NCCLS) guidelines.
Results: Out of the total sample of 212, 40(18.8%) cases were isolated as Salmonella species. Out of these, 29(72.5%) cases were S typhi and 11(27.5%) were S paratyphi. Isolates were mainly from adult age group. Regarding the antibiotic susceptibility pattern, the sensitivity to chloramphenicol was 95% and to cotrimoxazole 97% whereas the sensitivity to ciprofloxacin was 52.5% and 27.5% for Ofloxacin. Nalidixic Acid Resistance Salmonella typhi strain was 60.0 percent. Sensitivity to ceftriaxone, meropenem and colistin was found to be 100 percent.
Conclusions: A high degree of variability is seen in antimicrobial sensitivity pattern with very high degree of sensitivity to the historically used antibiotics like chloramphenicol and cotrimoxazole. Unfortunately, sensitivity to quinolones was seen to be very low, which were used widely in the last two decades.
Pattern of hematological malignancy in a tertiary level hospital in Kathmandu
Authors: Shrestha Amar Narayan , Singh Sunil Kumar , Deo Rajiv Kumar , Joshi Rinku , Poudel Ayusha , Aryal Barun Babu , Adhikari Anurag 
Published: May 2019

Background: Hematological malignancies involve the blood elements, marrow, lymph and lymphatic elements and are among the common malignancies afflicting the human race. They tend to involve the extremes of the ages- the young and the elderly.
Materials and Methods: A hospital register based retrospective study was conducted including the data of five years duration. The confirmation of diagnosis was done with blood smear examination, bone marrow examination and flow-cytometry. The epidemiological parameters were then calculated using Microsoft Excel and SPSS.
Results: Among the total number of cases, 60.7% were males and 39.3% were females. Age group of 50 to 59 years was most commonly involved. Lymphoma (including Hodgkin’s and non-Hodgkin’s) was the most common hematological malignancy.
Conclusions: Males are more afflicted by hematological malignancies and lymphoma was the commonest hematological malignancy.
Evaluation of Prostate specific antigen levels and its correlation with histopathological findings
Authors: Pudasaini Sujata , Subedi Neeraj , Shrestha Nagesh Mani 
Published: May 2019

Background: Prostate specific antigen is a tumor marker though is expressed by both normal and neoplastic prostate tissue. The absolute value of Prostate specific antigen is useful for determining the extent of prostate cancer and its treatment. Prostate specific antigen also increases in cases like Benign Prostatic Hyperplasia and prostatitis. The availability of Prostate specific antigen as a marker has encouraged its use to diagnose both cancer and cancer recurrences.
Materials and methods: This is a cross sectional study conducted in a tertiary hospital over a period of two years. Cases of prostatic disease undergoing surgery during the study period were taken. Prostate specific antigen level of all these cases were correlated with clinical and histopathological findings.
Results: A total of 51 cases of prostatic disease underwent surgery during the study period with the mean age of 66.57 ± 10.68 years. On histopathological examination, 70.6% had benign prostatic hyperplasia and 17.6% had prostatic adenocarcinoma. Prostate specific antigen level was <4 ng/ml in 45.1% cases and >20.1ng/ml in 15.7%. In case of carcinoma prostate, 88.9% had prostate specific antigen level > 20.1ng/ml and 11.1% had prostate specific antigen level in a range of 10.1- 20 ng/ml. In case of chronic prostatitis, 66.7% had prostate specific antigen level in a range of 4.1-10 ng/ml. However, in case of high grade prostatic intraepithelial neoplasia (HGPIN), 66.7% had PSA level <4 ng/ml.
Conclusions: Strong correlation of prostate specific antigen levels of > 20.1 ng/ml with carcinoma prostate was seen.
Histopathology of important fungal infections – A summary
Authors: Ghosh Arnab , Gharti Magar Dilasma , Thapa Sushma , Nayak Niranjan , Talwar Om Prakash 
Published: May 2019

Fungal infections due to pathogenic or opportunistic fungi may be superficial, cutaneous, subcutaneous and systemic. With the upsurge of at risk population systemic fungal infections are increasingly common. Diagnosis of fungal infections may include several modalities including histopathology of affected tissue which reveal the morphology of fungi and tissue reaction. Fungi can be in yeast and / or hyphae forms and tissue reactions may range from minimal to acute or chronic granulomatous inflammation. Different fungi should be differentiated from each other as well as bacteria on the basis of morphology and also clinical correlation. Special stains like GMS and PAS are helpful to identify fungi in tissue sections.
VARIETAL COMPOSITION AND FREQUENCY OF FUSARIUM PRESENCE ON WINTER WHEAT VARIETIES IN THE TAMBOV REGION
Authors: Buchneva G. N. , Gusev I. V. , Korabelskaya O. I. , Dubrovskaya N. N. , Chekmarev V. V. 
Published: May 2019

In the climatic conditions of the Central Black-earth region, the infection of wheat grain with Fusarium fungi is of latent nature and can only be detected by mycological analysis. For this reason, the varietal composition of the pathogenic complex of fungi Fusarium on winter and spring wheat has not been thoroughly studied yet. Working with the problem in the conditions of the Tambov region, it was found that the grain of these varieties was infected with various species of Fusarium. The most infected spring wheat varieties were “Nik” (69%), “Biora” (45%) and “Prokhorovka” (30%). The varieties “Saratovskaya 29” (4%) and “Tulaikovskaya 100” (5%) were less infected than the other. Nine species of fungus Fusarium spp. found on spring wheat seeds were F. acuminatum Ellis, an Everhart (1895), a Wollenweber (1917), F. avenaceum (Corda ex Fries) Saccardo (1886), F. culmorum (WG Smith) Saccardo (1895), F. equiseti (Corda) Saccardo (1886), F. poae (Peck) Wollenweber in Lewis (1913), F. sambucinum Fuckel (1869), F. semitectum Berkeley and Ravenel in Berkeley (1875), F. sporotrichioides Sherbakoff (1915) and F. tricinctum (Corda) Saccardo (1886). The leading position was occupied by the species Fusarium sporotrichioides and F. avenaceum. The frequency of their occurrence on spring wheat seeds was 56.6 and 20.9%, respectively. The contamination of winter wheat with a Fusarium fungus was lower than the infection of spring wheat (1–8%). Four species of Fusarium spp. were identified on the seeds of winter wheat, they are F. avenaceum (Corda ex Fries) Saccardo (1886), F. graminearum Schwabe (1838), F. poae (Peck) Wollenweber in Lewis (1913) and F. sporotrichioides Sherbakoff (1915). The dominant position belonged to the species Fusarium poae and F. sporotrichioides (41.7 and 37.5%). It has been shown that the level of infection of wheat seeds by Fusarium fungi depends on the variety resistance to the infection.
Researches of the assortment of drugs for the treatment of diabetes II type оn the pharmaceutical market of Ukraine
Authors: Kovalevska I. V. , Ruban O. A. , Yevtushenko O. M. 
Published: May 2019

Type II diabetes is a global pandemic, as evidenced by data from a study by the International Diabetes Federation. The disease is a chronic, progressive process with a special metabolic condition that is characterized by hyperglycemia. Therapeutic effects should be aimed at eliminating the main causes of type II diabetes mellitus: insulin secretion dysfunction, a decrease in tissue resistance to insulin, or a combination of these. The aim of the work was to study the range of oral antidiabetic drugs on the pharmaceutical market of Ukraine for the treatment of type II diabetes. The objects of study were drugs used in the treatment of type II diabetes. Studies were conducted using content analysis of official sources of information. In the course of the work, the range of antidiabetic drugs, classification, mechanism of action, cost, main advantages and disadvantages of use were established. It is established that the most common dosage form for the treatment of diabetes are tablets, which occupy more than 90% of the total range of drugs. The lack of modern types of dosage forms in the group A10B is the basis for the creation of new drugs with improved biopharmaceutical and consumer properties.
The data obtained indicate a strong dependence of the pharmaceutical market of antidiabetic drugs of Ukraine on imports, with the exception of insulin (А10В). The share of imports in the market in quantitative terms for the period under review amounted to more than 75.86% of the total market volume.
It has been established that the use of drugs of the A10B A, A10B F groups with an affordable cost with active therapy contributes to a lower rate of development of diabetes mellitus type II and a high degree of regression to normal glucose, without affecting the fluctuations in body weight. Preparations of the new generation (A10B H, A10B J, A10B X) are highly effective with an insufficient safety profile. The high cost of drugs of these groups makes them inaccessible to the general population. It has been shown that only metformin and voglibosis have a positive effect on body mass fluctuation rates, which will ensure safe and effective glycemic control with minimal risk of hypoglycemia and without weight gain in the treatment of type II diabetes.
FDTD Analysis Fiber Optic SPR Biosensor for DNA Hybridization: A Numerical Demonstration with Graphene
Authors: Islam Md. Muztahidul , Islam Md. Mohaiminul , Shimul Youshuf C. , Rahman Azizur , Ruhe A. Akib , Hassan Mehedi , Hossain Md. Biplob 
Published: May 2019

This article illustrates a design and finite difference time domain (FDTD) method based on analysis of fiber optic surface plasmon resonance (SPR) biosensor for biomedical application especially for DNA-DNA hybridization. The fiber cladding at the middle portion is constructed with the proposed hybrid of gold (Au), graphene, and a sensing medium. This sensor can be recognized adsorption of DNA biomolecules onto sensing medium of PBS saline using attenuated total reflection (ATR) technique. The refractive index (RI) is varied owing to the adsorption of different concentration of biomolecules. Result states that the sensitivity with a monolayer of graphene will be improved up to 40% than bare graphene layer. Owing to increased adsorption capability of DNA molecules on graphene, sensitivity increases compared to the conventional gold thin film SPR biosensor. Numerical analysis shows that the variation of the SPR angle for mismatched DNA strands is quite negligible, whereas that for complementary DNA strands is considerable, which is essential for proper detection of DNA hybridization. Finally, the effect of Electric field distribution on inserting graphene layer is analyzed incorporating the FDTD technique by using Lumerical FDTD solution software.
Kegel’s Exercise could Reduce the Incidence of Postpartum Urinary Stress Incontinence
Authors: Abdullah Nusratuddin , Arsyad Eddy 
Published: May 2019

Objective: To investigate the cause of postpartum urin ary incontinence in primi gravida women and to determin e the relationship between stress urinary incontinence and kegel's exercise.
Method: This was an observational study with cross sectional method , perform ed in instituti onal hospitals in Makassar. Thirty primigravida women who performed kegel's exercise were compared with 30 primi gravida women who did not perform kegel's exercise. Data were analyzed with independent-t sta tistical analysis.
Result: Urinary incontinence were significantly lower in primigravida women who performed kegel's exercise (P=O.OOO).
Conclusion: Kegel's exercise may reduce the incidence of postpartum stress urinary incontinence.
Keywords: kegel's exercise, primigravida, urinary Incontinence.
Effectiveness Management of Qualitative Research in Writing Scientific Papers
Authors: Royadi Dedi , Susiana Nancy , Khumaida Fina Andhara 
Published: May 2019

Good scientific work must have data that is not surprising or real facts. In managing this work, significant research methods are needed. However, some management uses in research are still not maximal and do not know the limitations of qualitative research. For example, are there researchers who do not yet know clearly what forms of management will be qualitative. Qualitative forms are often referred to as in accordance with quality. In this study will discuss the management of qualitative, qualitative, qualitative, and qualitative research. The existence of this study is expected to be used in research as well as using qualitative research procedures.
Keywords: management, qualitative research, perspective.