bluuebunny/crossref_metadata_2025_split huggingface dataset:
Combined Pathology-Driven Algorithmic Testing and Integrated Reporting for Bone Marrow Examination
Authors: Pearson Lauren N. , Miller Jill M. , Lunde John H. , Bryant Ronald J. , Lewis Michael R. , Tang Mary E. 
Published: January 2019

Context.—
The College of American Pathologists published guideline recommending bone marrow synoptic reporting for hematologic neoplasms.

Objective.—
To evaluate the impact of pathology-driven algorithmic testing (PDAT) with integrated reporting for bone marrow examination on test utilization, ability to render a specific World Health Organization diagnosis, and clinician satisfaction 1 year after implementation.

Design.—
We reviewed the hematopathology reports, integrated synoptic reports, and ancillary test results generated during a 12-month period. The initial diagnosis from the hematopathology report was compared with the final diagnosis on the integrated synoptic reports. Test utilization data were compared with a previous year in which ancillary testing was ordered at clinician discretion. Clinicians were anonymously surveyed to assess their satisfaction with PDAT and integrated reporting.

Results.—
Integrated reporting resulted in a World Health Organization diagnosis for 80 of 85 cases (94%) compared with 54 (64%) for the hematopathology report alone. Unnecessary testing decreased from 45% pre-PDAT (124 of 274 cases) to 0.7% PDAT (2 of 268 cases), and PDAT resulted in fewer omissions of necessary tests. Clinicians preferred PDAT and valued integrated reporting for a variety of reasons, including the ease of finding relevant prognostic information.

Conclusions.—
Pathology-driven algorithmic testing with integrated reporting improves the pathologist's ability to render a specific World Health Organization diagnosis and improves test utilization. Clinicians prefer PDAT to clinician-ordered testing. This is the first study to examine how synoptic reporting can modify hematologic diagnoses.
Documenting Linguistic Knowledge in an Inuit Language Atlas
Authors: Murasugi Kumiko , Ittusardjuat Monica 
Published: January 2019

The traditional method of orally transmitting language is weakening with the passing of fluent Elders and language erosion in contemporary Inuit society. Language documentation is a vital component of language maintenance and revitalization. In this paper we present a pilot online, multimedia cybercartographicAtlas of the Inuit Language in Canada, the goal of which is to help protect and strengthen the vitality of Inuit dialects through the documentation of their words. The main component of the atlas is a multidialectal database of written and spoken words. We discuss the role of dictionaries in language documentation, introduce the features of the atlas, explore the appeal of the atlas to different types of users (in particular, language learners), and present future directions for the atlas project.
Generating case notes from digital transcripts using text mining
Authors: Kazi Nazmul , Kahanda Indika 
Published: January 2019

Current health care systems require clinicians to spend a substantial amount of time to digitally document their interactions with their patients through the use of electronic health records (EHRs), limiting the time spent on face-to-face patient care. Moreover, the use of EHRs is known to be highly inefficient due to additional time it takes for completion, which also leads to clinician burnout. In this project, we explore the feasibility of developing an automated case notes system for psychiatrists using text mining techniques that will listen to doctor-patient conversations, generate digital transcripts using speech-to-text conversion, classify information from the transcripts by identifying important keywords, and automatically generate structured case notes.
In our preliminary work, we develop a human powered doctor-patient transcript annotator and obtain a gold standard dataset through National Alliance of Mental Illness (NAMI) Montana. We model the task of classifying parts of conversations in to six broad categories such as medical and family history as a supervised classification problem and apply several popular machine learning algorithms. According to our preliminary experimental results obtained through 5-fold cross validation, Support Vector Machines are able to classify an unseen transcript with an average AUROC (area under the receiver operating characteristic curve) score of 89%. Using part-of-speech (POS) tagging, grammatical rules of English language and verb conjugation, we generate formal representation of each sample. For each class, we form a paragraph using the formal representations of its samples. Using these paragraphs, we generate a case note.
Facile Synthesis of Ag3PO4 Photocatalyst with Varied Ammonia Concentration and Its Photocatalytic Activities For Dye Removal
Authors: Febiyanto Febiyanto , Soleh Agus , Amal Muhammad Sofi Khoerul , Afif Mohammad , Sewiji Sukma , Riapanitra Anung , Sulaeman Uyi 
Published: January 2019

The highly active photocatalyst of Ag3PO4 could be synthesized under ammonia solution using the facile co-precipitation method with the starting material of AgNO3 and Na2HPO4.12H2O. The variation of ammonia concentration was designed at 0.00, 0.05, 0.15, and 0.30 M. The products were characterized using X-ray diffraction, UV-diffuse reflectance spectroscopy, and scanning electron microscopy. The photocatalytic activities were evaluated using the Rhodamine B degradation under blue light irradiation. The effect of calcination, pH condition, and visible light source irradiation was carried out in the experiment. The highest photocatalytic activity was found in the sample prepared using the addition of ammonia solution at the concentration of 0.05 M. This photocatalytic activity was 4.13 times higher compared to the Ag3PO4 prepared without the ammonia. The effective condition of photocatalytic activity was achieved at the sample prepared without calcination, degradation at pH of 7 and under blue light irradiation.
Prevalence of Hiv/Tb Coinfection in Patients from a Referral Hospital in Rio de Janeiro City / Prevalência da Coinfecção Hiv/Tb em Pacientes de um Hospital de Referência na Cidade do Rio De Janeiro
Authors: Ferreira Débora Paula , Souza Fabiana Assumpção de , Motta Maria Catarina Salvador da 
Published: January 2019

Objetivos: estimar a prevalência de coinfecção HIV/TB em pacientes submetidos a tratamento de TBMR em um hospital de referência do Rio de Janeiro. Método: Uma investigação transversal, cuja população foi composta por 40 pacientes em tratamento para TBMR, no período de março a dezembro de 2016. Para análise estatística utilizou-se o programa estatístico SPSS. Resultados: No período em estudo foram diagnosticados 40 casos de TBMR, dos quais 9 mostraram sorologia positiva para HIV, o que representou uma taxa de coinfecção de 22,5%. Nesse grupo predominou o sexo masculino (85,29%) e a média 37,5 anos. O diagnóstico de TB nos coinfectados prevaleceu a forma clínica pulmonar (80%). No teste do esfregaço, (66,6%) apresentaram resultado positivo, (74,9%) radiologia sugestiva e 100% dos pacientes apresentaram resistência a rifampicina no teste do Gene Xpert. Conclusão: As drogas que apresentaram-se mais resistentes neste grupo foram rifampicina, isoniazida e estreptomicina (87,5%).
Cancer Prevention Europe
Authors: Wild Christopher P. , Espina Carolina , Bauld Linda , Bonanni Bernardo , Brenner Hermann , Brown Karen , Dillner Joakim , Forman David , Kampman Ellen , Nilbert Mef , Steindorf Karen , Storm Hans , Vineis Paolo , Baumann Michael , Schüz Joachim 
Published: January 2019

The case for cancer prevention in Europe is the same as for all other parts of the world. The number of cancers is increasing, driven by demographic change and evolution in the exposure to risk factors, while the cost of treating patients is likewise spiralling. Estimations suggest that around 40% of cancers in Europe could be prevented if current understanding of risk and protective factors was translated into effective primary prevention, with further reductions in cancer incidence and mortality by screening, other approaches to early detection, and potentially medical prevention. However, the infrastructure for cancer prevention tends to be fragmented between and within different countries in Europe. This lack of a coordinated approach recently led to the foundation of Cancer Prevention Europe (Forman et al., 2018), a collaborative network with the main aims of strengthening cancer prevention in Europe by increasing awareness of the needs, the associated required resources and reducing inequalities in access to cancer prevention across Europe. This article showcases the need for strengthening cancer prevention and introduces the objectives of Cancer Prevention Europe and its foreseen future role in reducing the European cancer burden.
Alkene Transfer Hydrogenation with Alkaline‐Earth Metal Catalysts
Authors: Bauer Heiko , Thum Katharina , Alonso Mercedes , Fischer Christian , Harder Sjoerd 
Published: January 2019

AbstractThe alkene transfer hydrogenation (TH) of a variety of alkenes has been achieved with simple AeN′′2 catalysts [Ae=Ca, Sr, Ba; N′′=N(SiMe3)2] using 1,4‐cyclohexadiene (1,4‐CHD) as a H source. Reaction of 1,4‐CHD with AeN′′2 gave benzene, N′′H, and the metal hydride species N′′AeH (or aggregates thereof), which is a catalyst for alkene hydrogenation. BaN′′2 is by far the most active catalyst. Hydrogenation of activated C=C bonds (e.g. styrene) proceeded at room temperature without polymer formation. Unactivated (isolated) C=C bonds (e.g. 1‐hexene) needed a higher temperature (120 °C) but proceeded without double‐bond isomerization. The ligands fully control the course of the catalytic reaction, which can be: 1) alkene TH, 2) 1,4‐CHD dehydrogenation, or 3) alkene polymerization. DFT calculations support formation of a metal hydride species by deprotonation of 1,4‐CHD followed by H transfer. Convenient access to larger quantities of BaN′′2, its high activity and selectivity, and the many advantages of TH make this a simple but attractive procedure for alkene hydrogenation.
Circular Polarized Light Activated Chiral Satellite Nanoprobes for the Imaging and Analysis of Multiple Metal Ions in Living Cells
Authors: Gao Rui , Xu Liguang , Hao Changlong , Xu Chuanlai , Kuang Hua 
Published: January 2019

AbstractHere, we construct a handedness‐dependent circular polarized light (CPL)‐activated chiral satellite assemblies formed from DNAzymes and spiny platinum modified with gold nanorods and upconversion nanoparticles (UCNPs), enabling the simultaneous quantitative analysis of multiple divalent metal ions in living cells. The chiral nanoprobes, in coordination with their corresponding divalent metal ions under 980 nm left circular polarized (LCP) light illumination, served as an in situ confocal bioimaging platform for the quantitation of the given intracellular metal ions. The limit of detection (LOD) of the chiral probes in living cells is 1.1 nmol/106 cells, 1.02 nmol/106 cells and 0.45 nmol/106 cells for Zn2+, Mg2+, and Cu2+, respectively.
The Dominant Role of Oxygen in Modulating the Chemical Evolution Pathways of Tyrosine in Peptides: Dityrosine or Melanin
Authors: Ren Xiaokang , Zou Qianli , Yuan Chengqian , Chang Rui , Xing Ruirui , Yan Xuehai 
Published: January 2019

AbstractIn diverse biological systems, the oxidation of tyrosine to melanin or dityrosine is crucial for the formation of crosslinked proteins and thus for the realization of their structural, biological, and photoactive functionalities; however, the predominant factor in determining the pathways of this chemical evolution has not been revealed. Herein, we demonstrate for tyrosine‐containing amino acid derivatives, peptides, and proteins that the selective oxidation of tyrosine to produce melanin or dityrosine can be readily realized by manipulating the oxygen concentration in the reaction system. This oxygen‐dependent pathway selection reflects the selective chemical evolution of tyrosine to dityrosine and melanin in anaerobic and aerobic microorganisms, respectively. The resulting melanin‐ and dityrosine‐containing nanomaterials reproduce key functions of their natural counterparts with respect to their photothermal and photoluminescent characteristics, respectively. This work reveals the plausible role of oxygen in the chemical evolution of tyrosine derivatives and provides a versatile strategy for the rational design of tyrosine‐based multifunctional biomaterials.
Soy Oil‐Based Rigid Polyurethane Biofoams Obtained by a Facile One‐Pot Process and Reinforced with Hydroxyl‐Functionalized Multiwalled Carbon Nanotube
Authors: Luo Xiaogang , Cai Yixin , Liu Liming , Zhang Fuqing , Wu Qiangxian , Zeng Jian 
Published: January 2019

AbstractHighly conductive, thermally insulating, and three‐dimensional (3D) macromolecular network‐structured nanocomposite biofoams with very low density were designed from soy oil‐based polyurethane (PU) and hydroxyl‐functionalized multiwalled carbon nanotubes (MWCNT‐OH) using a facile one‐pot process with water as the sole blowing agent. Scanning Electron Microscope (SEM), Transmission Electron Microscope (TEM) and Fourier Transform Infrared spectroscopy (FTIR) analyses revealed homogeneous dispersion as well as interaction or reaction of MWCNT‐OH with the PU biofoam matrix or a polymeric methylene diphenyl diisocyanate (MDI) to form a 3D macromolecular network structure. Mechanical properties and electrical conductivity were remarkably enhanced with the increase of MWCNT‐OH. Dynamic mechanical analysis and thermogravimetric analysis results showed that all the nanocomposite PU biofoam products had good thermal stability properties. Hence, the prepared nanocomposites hold promise as rigid biopolyurethane (BioPU) foams, serving the needs of the conductive composite material fields.
Structure variation and puncture resistance of stretched crosslinked polyethylene film: Effects of stretching temperature
Authors: Wang Rong , Ren Dongxue , Sun Xiaojie , Liang Wenbin , Wang Ke 
Published: January 2019

ABSTRACTCrosslinked polyethylene films were prepared and stretched at different temperatures (below and above melting temperature). The stretching temperature exhibited pronounced effects on the structure and puncture resistance of the films. Combining the results of differential scanning calorimetry, 1D X‐ray diffraction, 2D X‐ray diffraction, and scanning electron microscope, it was demonstrated that the film stretched above T
m has lower crystallinity, thinner lamellar, and larger crystal grain size than that stretched below but near T
m. All the stretched films showed highly oriented lamellae in the bulk and arranged perpendicular to the stretching direction. The crystals of the film stretched below T
m were arranged in highly aligned microfibrils with distinct interlamellar boundary and the crystals of the film stretched above T
m were arranged in a progressively less orderly manner with increased interlamellar entanglement. Due to this structure difference, the puncture resistances of the films stretched above T
m were much larger than that stretched below T
m. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 47542.
Novel microfluidic graphene oxide–protein amperometric biosensor for detecting sulfur compounds
Authors: Ghaemi Amirhossein , Abdi Kaveh , Javadi Shohreh , Shehneh Masoud Zare , Yazdian Fatemeh , Omidi Meisam , Rashedi Hamid , Haghiralsadat Bibi Fatemeh , Asayeshnaeini Omid 
Published: January 2019

AbstractSulfur compounds are essential for many industries and organisms; however, they cause serious respiratory problems in human beings. Therefore, determination of sulfur concentration is of paramount importance. The research approach in the field of detecting contaminants has led to smaller systems that provide faster and more effective ways for diagnosis purposes. In this study, a novel portable amperometric graphene oxide–protein biosensor platform is investigated. The main characteristic of this structure is the implementation of a microfluidic configuration. With albumin metalloprotein as the biorecognition element, graphene oxide was synthesized and characterized by transmission electron microscopy and Fourier‐transform infrared spectroscopy (FTIR). Albumin protein was stabilized on the surface of graphene oxide by the application of the N‐(3‐dimethylamionpropyl)‐N‐ethylcarbodiimide hydrochloride/N‐hydroxysuccinimide method. The stabilization was confirmed by FTIR and electrochemistry analyses. The calibration curve of sulfur concentration was determined. When the graphene oxide–protein complex was stabilized by nephion on the surface of the microfluidic system, the response time reduced to 50 Sec, which is a relatively faster response among the similar studies and validated the significant effect of the microfluidic system. The nanosystem had an optimized pH of 7.4 and exhibited high sensitivity in determining sulfide. The results confirm that the portable graphene oxide–protein nanosystem has a fast and accurate response in detecting sulfide.
Hemoprotein‐Catalyzed Cyclopropanation En Route to the Chiral Cyclopropanol Fragment of Grazoprevir
Authors: Kim Taejin , Kassim Amude M. , Botejue Ajit , Zhang Chen , Forte Jared , Rozzell David , Huffman Mark A. , Devine Paul N. , McIntosh John A. 
Published: January 2019

AbstractReactions that were once the exclusive province of synthetic catalysts can increasingly be addressed using biocatalysis. Through discovery of unnatural enzyme reactions, biochemists have significantly expanded the reach of enzymatic catalysis to include carbene transfer chemistries including olefin cyclopropanation. Here we describe hemoprotein cyclopropanation catalysts derived from thermophilic bacterial globins that react with diazoacetone and an unactivated olefin substrate to furnish a cyclopropyl ketone, a previously unreported reaction for enzyme catalysts. We further demonstrate that the resulting cyclopropyl ketone can be converted to a key cyclopropanol intermediate that occurs en route to the anti‐hepatitis C drug grazoprevir.
Ambipolar Discotic Liquid Crystals Built Around Platinum Diimine‐Dithiolene Cores
Authors: Camerel Franck , Albert Grégory , Barrière Frédéric , Lagrost Corinne , Fourmigué Marc , Jeannin Olivier 
Published: January 2019

AbstractPlatinum diimine dithiolene complexes bearing mesogenic groups on one or both ligands have been prepared through an original ligand metathesis reaction to introduce the dithiolene ligand. The neutral diimine ligands, the intermediate platinum dichloride diimine complexes, and the target compounds were characterized by a combination of electronic (electrochemistry, absorption and emission spectroscopy, DFT calculations) and structural (SAXS, DSC) tools. Several novel liquid crystalline platinum diimine‐dithiolene were identified over a large temperature range, and the systems were endowed with ambipolar properties, associated with the high reversibility of both oxidation and reduction processes.
Assignment of the Absolute‐Handedness Chirality of Single‐Walled Carbon Nanotubes by Using Organic Molecule Supramolecular Structures
Authors: Abd El‐Mageed Ahmed I. A. , Handayani Murni , Chen Zhijin , Inose Tomoko , Ogawa Takuji 
Published: January 2019

AbstractInvited for the cover of this issue is the group of Prof. Takuji Ogawa (Osaka University) and Dr. Ahmed I. A. Abd El‐Mageed (Osaka University and Minia University). The image depicts the first experimental identification of the single‐walled carbon nanotubes (SWNT) absolute handedness chirality using scanning tunnelling microscopic images of supramolecular structures of porphyrin derivatives. Read the full text of the article at 10.1002/chem.201804832.
Optimization of color design for military camouflage in CIELAB color space
Authors: Lin Chiuhsiang Joe , Prasetyo Yogi Tri , Siswanto Nio Dolly , Jiang Bernard C. 
Published: January 2019

AbstractThe assessment of military camouflage is a key consideration in the modern military field. Traditionally, the assessment relies on traditional human visual detection tests because a large scale multi‐level and multi‐factor experiments are time‐ and resource‐consuming. One aspect of camouflage assessment, to which this current study pertains, entails improving upon or “enhancing” an existing or “selected” design. The current study presents a new and practical approach for enhancing the selected military camouflage by utilizing response surface methodology (RSM) of %L*, %a*, and %b* in CIELAB color space. Ten participants were recruited to evaluate 35 variations of %L*, %a*, and %b* on camouflage similarity index (CSI) and reaction time (RT). Based on RSM, the optimum combination occurs at L*: 61.4966, a*: −5.6505, and b*: 10.5114. In addition, a predictive algorithm to calculate the optimum shift of %L*, %a*, and %b* from the original camouflage to the improved camouflage derived from RSM is also proposed. The optimum shift occurs at −25%L*, −55%a*, and + 80%b*. In the end, a new design guideline is proposed for the enhancement of selected military camouflage, which adopts the present study's research findings.
Synthesis and Investigation on Structural, Thermal, Mechanical, Linear Optical, and Nonlinear Optical Nature of Potassium Sulphato Oxalate Single Crystals
Authors: Punniyamoorthy R. , Manimekalai R. , Uma K. , Pasupathi G. 
Published: January 2019

AbstractThe new semiorganic potassium sulphato oxalate (KSO) single crystals are grown at room temperature by a slow evaporation method using an aqueous solution. The Fourier transform infrared spectroscopy is used to ascertain the various functional groups present in the grown KSO sample. The single crystal X‐ray diffractometer (XRD) results confirm the grown KSO crystal is a triclinic structure with lattice parameters a = 6.37 Å; b = 7.03 Å; c = 10.61 Å; and space group P1. Powder XRD study proves the crystallinity and purity of the grown crystal. The optical behaviors of KSO are analyzed by UV–vis‐near infrared reflectance (NIR) spectrophotometer. Photoluminescence (PL) studies of KSO reveal its strong green emission at 576 nm. The laser damage threshold (LDT) of the title compound is measured to be 6.135 GW/cm2. The thermo gravimetric and differential thermal analysis indicated that KSO is stable up to 103 °C. From the Vickers microhardness tester, the mechanical behaviors of the title compound are studied. The frequency conversion property of KSO crystal is analyzed using Kurtz–Perry method, and it is found to be 1.16 times higher than that of the reference potassium dihydrogen phosphate which indicates KSO is well suited for optoelectronic device fabrication.
Protein‐Rich Biomass Waste as a Resource for Future Biorefineries: State of the Art, Challenges, and Opportunities
Authors: De Schouwer Free , Claes Laurens , Vandekerkhove Annelies , Verduyckt Jasper , De Vos Dirk E. 
Published: January 2019

AbstractProtein‐rich biomass provides a valuable feedstock for the chemical industry. This Review describes every process step in the value chain from protein waste to chemicals. The first part deals with the physicochemical extraction of proteins from biomass, hydrolytic degradation to peptides and amino acids, and separation of amino acid mixtures. The second part provides an overview of physical and (bio)chemical technologies for the production of polymers, commodity chemicals, pharmaceuticals, and other fine chemicals. This can be achieved by incorporation of oligopeptides into polymers, or by modification and defunctionalization of amino acids, for example, their reduction to amino alcohols, decarboxylation to amines, (cyclic) amides and nitriles, deamination to (di)carboxylic acids, and synthesis of fine chemicals and ionic liquids. Bio‐ and chemocatalytic approaches are compared in terms of scope, efficiency, and sustainability.