bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sulfonated Covalent Organic Frameworks Anchoring Cobalt as High‐Efficient and Stable Catalysts for Peroxymonosulfate Activation
Authors: Zhang Xinke , Li Yutong , Cao Fengliang , Sun Xiaohui , Jin Zhihan , Xue Song , Wagner Manfred , Zhi Linjie 
Published: October 2024

AbstractHeterogeneous cobalt‐based catalysts are highly effective in activing peroxymonosulfate (PMS) and produce free radicals to deal with recalcitrant organic pollutants in water. However, unfeasible recyclability and gradual performance degradation remain challenging due to the easy agglomeration and leaching of active cobalt species. Herein, a strategy is proposed to construct stably anchored and highly dispersed Co2+ sites on dual functional sulfonated covalent organic frameworks (COF‐Co). The sulfonic acid groups are able to realize the targeted binding with cobalt ions through a two‐step cation‐exchange method, leading to strong combination with active Co2+ sites and utmost utilization efficiencies. Moreover, the super‐hydrophility of sulfonic acid groups favors the rapid accessibility of organic molecules to the catalyst and accelerates the degradation. Remarkably, COF‐Co exhibits high activity in PMS activation, effective oxidation for tetracycline degradation (92% within 30 min at 30 mg L−1) and other coloring contaminants, and excellent recycle stability. This work can guide the rational design of efficient and environmentally friendly PMS‐activated catalyst with great potential for application in wastewater treatment.
Delta‐Like Homolog 2 Facilitates Malignancy of Hepatocellular Carcinoma via Activating EGFR/PKM2 Signaling Pathway
Authors: Liu Xiangye , Li Tingting , Wang Yuting , Gao Xiaoge , Wang Feitong , Chen Yang , Wang Kaisheng , Luo Weiming , Kong Fanyun , Kou Yanbo , You Hongjuan , Kong Delong , Zhang Qing , Tang Renxian 
Published: October 2024

ABSTRACTDelta‐like homolog 2 (DLK2) plays a crucial role in adipogenesis, chondrogenic differentiation, and the progression of certain cancers. However, the key roles of DLK2 underlying the progression of hepatocellular carcinoma (HCC) remain ambiguous. In the current study, we demonstrate that DLK2 is upregulated in HCC, significantly correlated with clinicopathological variables and serves as an independent diagnostic marker. Functional assays reveal that DLK2 facilitates malignant progression of HCC in vitro and in vivo models. Mechanistically, DLK2 binds to EGFR resulting in its auto‐phosphorylation, which activates NF‐κB pathway leading to P65‐dependent transcriptional upregulation of PKM2. Furthermore, that elevates both enzyme‐dependent and ‐independent activities of PKM2 contributing to cancer proliferation and metastasis. In summary, our findings demonstrate a novel pro‐tumoral role and mechanism of DLK2 in the regulation of HCC malignant progression, suggesting its potential as a clinical diagnostic marker and therapeutic target.
Effect of Technological Innovation, Servitisation and Human Capital Structure on Performance in Manufacturing Enterprises
Authors: Ying Miao , Yue Shi , Hao Jing 
Published: October 2024

ABSTRACTTo analyse the relationships amongst technology innovation, servitisation, human capital structure and performance in manufacturing firms, a sample of 1247 manufacturing firms listed on the A‐share market in China from 2013 to 2020 were collected. The conclusions are as follows. (1) Technological innovation has positive effect on performance. (2) Service transformation can mediate the effect of technological innovation on performance. (3) Advanced human capital skills can positively moderate the effect of service transformation on performance, whereas advanced human capital education can positively moderate the effect of technological innovation on performance. (4) The effect differs by firm type and location.
Atypical Presentation of Congenital Insensitivity to Pain With Anhidrosis Leading to Diagnostic Odyssey
Authors: Higashimoto Tomoyasu , Garber Martin E. , Hipp Lauren , Damon Jenna , Li Qing 
Published: October 2024

ABSTRACTBackgroundCongenital insensitivity to pain with anhidrosis (CIPA) (OMIM 256800) is a rare autosomal‐recessive condition, also known as hereditary sensory and autonomic neuropathy type IV (HSAN‐IV). The most commonly reported features include anhidrosis, intellectual disability, self‐mutilation, febrile episodes, impaired temperature perception, recurrent infections and/or autonomic nervous system impairment. Major joint destruction and joint deformity known as Charcot (neuropathic) joints are also seen in CIPA patients attributed to insensitivity to joint pain.MethodsWe present a case of a 46‐year‐old female affected with CIPA with a known NTRK1 variant and previously unidentified variant. Minigene reporter constructs were generated encompassing the exon 8 to exon 13 of the NTRK1 gene using the reference sequence and one harboring c.1483 + 5G > A variant identified in our proband. Minigene constructs were transfected into HEK293T cells, and the transcript was analysed for splicing to evaluate the effect of this variant in splicing.ResultsThe patient (46‐year‐old female) exhibited right ankle joint deformity around 5 years of age. Patient also experienced lumbar compression and knee damage in adulthood. She had undergone a significant number of evaluations without clear diagnosis. Her presentation lacked many of the common clinical presentations of CIPA, and therefore, the focus of her evaluation was directed towards her unexplained joint deformities. Exome sequencing revealed a known pathogenic variant in NTRK1 (c.851 ‐ 33T > A:p.? [Intron 7]) and a novel NTRK1 variant (c.1483 + 5G > A:p.? [Intron 11]), which was later re‐classified as likely pathogenic. The patient was started on a biologic disease‐modifying anti‐rheumatic medication (bDMARD) due to a possible inflammatory etiology of her joint deformity. Molecular diagnosis allowed for modification of her treatment and surveillance strategies. Our minigene splicing assay demonstrated that the presence of the c.1483 + 5G > A variant has a negative effect on splicing, supporting the pathogenicity of this novel variant.
Serum Concentrations of Folate Forms Following Supplementation of Multimicronutrients with 400 µg or 800 µg Mix of (6S)‐5‐Methyltetrahydrofolate and Folic Acid (1:1) in Women of Childbearing Age
Authors: Obeid Rima , Rube Elena , Schön Christiane , Geisel Jürgen 
Published: October 2024

ScopeA mixture of (6S)‐5‐methyltetrahydrofolate‐calcium salt ((6S)‐5‐MTHF‐Ca) and folic acid (FA) from multimicronutrient supplements may show a dose‐dependent effect on serum folate concentrations.Methods and resultsThe study compares fasting concentrations of serum folate spices after 8 weeks of either 400 or 800 µg day−1 of 1:1 folate mixture in 172 nonpregnant women. Serum (6S)‐5‐MTHF concentrations raise from a mean (SD) of 19.1 (13.4) to 73.9 (19.6) nmol L−1 in the 800 µg group and from 17.5 (9.4) to 54.5 (21.1) nmol L−1 in the 400 µg group (p < 0.001 within‐group changes). The raise in serum (6S)‐5‐MTHF is stronger in the 800 µg compared to the 400 µg group (p < 0.001 between‐group). The prevalence of FA concentrations ≥0.20 nmol L−1 increases between baseline and week 8 in both groups, but is not different between the groups (p = 0.116). The mean percentage of (6S)‐5‐MTHF of total serum folate increases in both intervention groups, but is not different between the groups at 8 weeks (95.5 (4.1)% versus 94.4 (5.7)%, p = 0.309).ConclusionsSupplementation of multimicronutrients with 800 µg folate mix for 8 weeks causes higher serum (6S)‐5‐MTHF concentrations, but not a higher prevalence of detectable FA compares to 400 µg folate.
A compact dual‐band omnidirectional antenna with folded microstrip lines and slotlines for 5G applications
Authors: Dou Jiangling , Chen Haokang , Gong Hao , Chen Yujie , Shen Tao , Song Jian 
Published: October 2024

AbstractA compact dual‐band omnidirectional antenna with folded microstrip lines and slotlines is proposed. The antenna is composed of a substrate and a superstrate. The superstrate is employed to broaden the antenna bandwidth. The radiating patch is situated on the upper surface of the substrate and consists of folded microstrip lines. The performance of the high‐frequency band can be optimized based on the analysis of the current distribution intensity. The bottom of the substrate is composed of a ground plane with slotlines. The introduction and improvement of the low‐frequency band are achieved by modifying the ground plane structure with characteristic modal analysis. The antenna demonstrates omnidirectional radiation characteristics across both frequency bands. The dimensions of the antenna are π × 0.178 λ0 × 0.178 λ0 × 0.049 λ0 (π × 22 × 22 × 6 mm). The antenna achieves a maximum gain of 3.37 dBi at 2.5 GHz and 2.74 dBi at 5.8 GHz. The measured impedance bandwidths for the two frequency bands are 17.3% and 21.7%, respectively.
Early Cell Lineage Formation in Mammals: Complexity, Species Diversity, and Susceptibility to Disruptions Impacting Embryo Viability
Authors: Latham Keith E. 
Published: October 2024

ABSTRACTThe emergence of the earliest cell lineages in mammalian embryos is a complex process that utilizes an extensive network of chromatin regulators, transcription factors, cell polarity regulators, and cellular signaling pathways. These factors and pathways operate over a protracted period of time as embryos cleave, undergo compaction, and form blastocysts. The first cell fate specification event separates the pluripotent inner cell mass from the trophectoderm lineage. The second event separates pluripotent epiblast from hypoblast. This review summarizes over 50 years of study of these early lineage forming events, addressing the complexity of the network of interacting molecules, cellular functions and pathways that drive them, interspecies differences, and aspects of these mechanisms that likely underlie their high susceptibility to disruption by numerous environmental factors that can compromise embryo viability, such as maternal health and diet, environmental toxins, and other stressors.
Rehabilitation is [still] necessary to optimize function in neuromuscular disorders
Authors: Omura Jaclyn , Stratton Anne , Fournier Christina , Howard Ileana 
Published: October 2024

AbstractThe landscape of care for children and adults with neuromuscular disorders (NMDs) is rapidly changing as more disease‐modifying treatments (DMTs) become available. These DMTs provide hope and opportunity for evolving phenotypes, though none (yet) are curative. Rehabilitation has been the standard of care for patients with NMDs and should remain so, even with the advent of novel DMTs. An interdisciplinary rehabilitation approach is holistic and comprehensive, addressing functional needs, musculoskeletal complications, pain, durable medical equipment, and bracing needs. This care will continue to be essential for patients who experience impairments and disability, despite receiving DMTs. Additionally, we must consider how to care for a new rapidly expanding cohort of patients aging with NMDs. Children with NMDs are expected to live longer into adulthood; a population that we may not have the workforce to support at this time. At this point, we have the perfect opportunity to reemphasize the importance of rehabilitation in the care of persons with NMDs, while we reexamine historical rehabilitation practices and innovatively deliver services to optimize the effects of these high‐cost DMTs.
Deformation Analysis of Cosserat Rods Using Piecewise Clothoid Approximation
Authors: Sivaj Sreejath , Saha Subir Kumar , Singh Satinder Paul 
Published: October 2024

AbstractThis paper presents an alternative to isogeometric analysis (IGA) for static analysis of planar curved slender beams. Geometrically exact Cosserat rod model is employed to establish the governing equations. In contrast to conventional IGA, which uses NURBS as the basis function, our method incorporates clothoid curves to represent the curved geometry. We use piecewise clothoid curves to approximate the initial curvature of the undeformed beam, facilitating a seamless integration into the Cosserat rod model. A straightforward solution of the governing equations is implemented using shooting method, verifying applicability across a range of problems. Interestingly, the parameters that define the clothoid segments also appear in the governing equations of the beam. This bridges the gap between the geometric design of the beams and their static simulations. In this way, we present the proposed formulation as an alternative to conventional IGA. The notable features of the method are easy implementation, good accuracy, and convergence. Moreover, the method predicts bending stress in the beam, capturing the nonlinearity of the deformation.
Anti‐VEGFR2 neutralising antibody slows the progression of multistep oral carcinogenesis
Authors: Shirogane Yoichiro , Usami Yu , Okumura Masashi , Hirose Katsutoshi , Naniwa Kohei , Ikebe Kazunori , Toyosawa Satoru 
Published: October 2024

AbstractAngiogenesis plays an important role in cancer growth and metastasis, and it is considered a therapeutic target to control tumour growth following anti‐angiogenic therapy. However, it is still unclear when tissues initiate angiogenesis during malignant transformation from premalignant condition and whether this premalignant condition could be a therapeutic target of anti‐angiogenic therapy. In this study, we aimed to analyse the onset of angiogenesis by evaluating morphological and functional alterations of microvessels during oral multistep carcinogenesis using a 4‐nitroquinoline 1‐oxide (4NQO)‐induced oral carcinogenesis mouse model. In the study, we initially confirmed that with the use of 4NQO, oral lesions develop in a stepwise manner from normal mucosa through oral epithelial dysplasia (OED) to oral squamous cell carcinoma (OSCC). Evaluation of CD31‐immunostained specimens revealed that microvessel density (MVD) increases in a stepwise manner from OEDs. Histological and functional analyses revealed the structural abnormalities and leakage of blood vessels had already taken place in OED. Then we evaluated the expression profiles of Hif1a and Vegfa along with hypoxic status and found that OED exhibited increased Vegfa expression under hypoxic conditions. Finally, we tested the possibility of OEDs as a target of anti‐angiogenic therapy and found that anti‐VEGFR2 neutralising antibody in OED slowed the disease progression from OED to OSCC. These data indicate that an angiogenic switch occurs at the premalignant stage and morphological, and functional alterations of microvessels already exist in OED. These findings also elucidate the tumour microenvironment, which gradually develops along with carcinogenic processes, and highlight usefulness of the 4NQO‐induced carcinogenesis model in the study of epithelial and stromal components, which will support epithelial carcinogenesis. © 2024 The Author(s). The Journal of Pathology published by John Wiley & Sons Ltd on behalf of The Pathological Society of Great Britain and Ireland.
Focused Ion Beam Milling as a Method for Machining Explosive Crystals**
Authors: Stirrup Kerry‐Ann M. , Gilpin Christopher J. , Chen Weinong W. 
Published: October 2024

AbstractExperimental pore collapse studies have traditionally relied on machining methods that are mechanically active and result in rough surfaces, added stresses, and premature material fractures which are a source of experimental error. This work focuses on the method development and the results of adapting the focused ion beam to mill micro and nano‐scale pores with increased geometrical freedom into explosive crystals. Results include developing a simplified mathematical relationship between the electron beam energy and mill rate, assessments of pore quality, and material and machine‐specific optimal milling parameters.
Association of race with incidence, characteristics, and mortality from incidental prostate cancer: Analysis of two North American contemporary cohorts
Authors: Finati Marco , Morrison Chase , Stephens Alex , Chiarelli Giuseppe , Cirulli Giuseppe Ottone , Tinsley Shane , Davis Matthew , Sood Akshay , Buffi Nicolò , Lughezzani Giovanni , Salonia Andrea , Briganti Alberto , Montorsi Francesco , Busetto Gian Maria , Bettocchi Carlo , Rogers Craig , Carrieri Giuseppe , Abdollah Firas 
Published: October 2024

AbstractBackgroundNon‐Hispanic Black (NHB) men are at higher risk both for incidence and mortality from prostate cancer (PCa) compared to Non‐Hispanic White (NHW) men, but these findings arise from biopsy‐detected PCa reports. We aimed to compare the incidence, subsequent management and cancer‐specific mortality (CSM) of incidental PCa among NHB and NHW men, using two different North American cohorts.MethodsThe Surveillance, Epidemiology and End‐Result (SEER: 2004‐2017) and our institutional Henry Ford Health (HFH: 1995‐2022) databases were queried to identify men diagnosed with incidental PCa. Cumulative incidence estimates were used to calculate CSM differences between NHB and NHW men. Competing‐risk multivariable regression analysis tested the impact of race on CSM, after accounting for all available covariates.ResultsA total of 418 and 6,124 incidental PCa cases were recorded in HFH and SEER database respectively. No pathological differences were observed between NHB and NHW men in both the cohorts, except for prostate‐specific antigen (PSA) value at diagnosis, which was higher in NHB men. At 10‐years, the CSM rates were 5.5% vs 7.2% in our cohort and 8.6% vs 10.3% in the SEER cohort for NHW and NHB men, respectively (all Gray's test p‐value > 0.05). At multivariable, race was not an independent predictor of CSM in our HFH cohort (HR: 1.46, 95% CI: 0.57‐3.71, p = 0.6). In the SEER cohort, NHB men were 34% less likely to die from PCa from 1 year to the next (95% CI: 0.49‐0.90, p = 0.008), when compared with NHW men.ConclusionsIn the comparison of incidental PCa findings between NHB and NHW men, both groups had similar pathological characteristic and survival outcomes. These findings are different from the ‘conventional’ screening‐detected PCa and suggest that racial differences have minimal to no adverse effects on PCa‐specific mortality after incidental diagnosis.
Assessing the predictive value of intraductal carcinoma of the prostate (IDC‐P) in determining abiraterone efficacy for metastatic hormone‐sensitive prostate cancer (mHSPC) patients
Authors: Wei Xinyuan , Zhao Jinge , Nie Ling , Shi Yifu , Zhao Fengnian , Shen Yu , Chen Junru , Sun Guangxi , Zhang Xingming , Liang Jiayu , Hu Xu , Shen Pengfei , Chen Ni , Zeng Hao , Liu Zhenhua 
Published: October 2024

AbstractBackgroundThis study explored the value of intraductal carcinoma of the prostate (IDC‐P) in predicting the efficacy of abiraterone treatment in metastatic hormone‐sensitive prostate cancer (mHSPC) patients.MethodsA retrospective study of 925 patients who underwent prostate biopsies to detect IDC‐P was conducted, with participants divided into two cohorts. The first cohort of 165 mHSPC patients receiving abiraterone treatment was analyzed to compare therapeutic effectiveness between IDC‐P positive and negative cases. Utilizing propensity score matching (PSM) to reduce bias, outcomes such as PSA response, progression‐free survival (PSA‐PFS), radiographic progression‐free survival (rPFS), and overall survival were assessed. Additionally, the second cohort of 760 mHSPC patients compared the efficacy of abiraterone with conventional hormone therapy, focusing on differences between IDC‐P positive and negative individuals.ResultsAfter PSM, our first cohort included 108 patients with similar baseline characteristics. Among them, 50% (54/108) were diagnosed with IDC‐P, with 22.2% (12/54) having IDC‐P pattern 1 and 77.8% (42/54) with IDC‐P pattern 2. While no notable difference was seen in PSA responses between IDC‐P positive and negative patients, IDC‐P presence linked to worse clinical outcomes (PSA‐PFS: 18.6 months vs. not reached [NR], p = 0.009; rPFS: 23.6 months vs. NR, p = 0.020). Further analysis showed comparable outcomes for IDC‐P pattern 1 but significantly worse prognosis for IDC‐P pattern 2 (PSA‐PFS: 18.6 months vs. NR, p = 0.002; rPFS: 22.4 months vs. NR, p = 0.010). Subgroup analysis revealed IDC‐P pattern 2 consistently predicted poorer outcomes across patient subgroups. Remarkably, both IDC‐P positive and negative patients gained more from androgen deprivation therapy with abiraterone than conventional treatment, with IDC‐P negative patients showing a more significant survival advantage, supported by better hazard ratios (0.47 and 0.66).ConclusionThis study found that IDC‐P, especially pattern 2, predicts poor prognosis in mHSPC patients on abiraterone therapy. Also, abiraterone's advantage over hormone therapy is reduced in cases with IDC‐P compared to those without.
Unraveling the molecular mechanism of FgGcn5 inhibition by phenazine‐1‐carboxamide: combined in silico and in vitro studies
Authors: Li Lei , Luo Qing , Yang Shuai , Wang Hancheng , Mu Yuguang , Guo Jingjing , Zhang Feng 
Published: October 2024

AbstractBACKGROUNDFusarium head blight (FHB), mainly caused by Fusarium graminearum (F. graminearum), remains a devastating disease worldwide. The histone acetyltransferase Gcn5 plays a crucial role in epigenetic regulation. Aberrant Gcn5 acetylation activity can result in serious impacts such as impaired growth and development in organisms. The secondary metabolite phenazine‐1‐carboxamide (PCN) inhibits F. graminearum by blocking the acetylation process of Gcn5 (FgGcn5), and is currently used to control FHB. However, the molecular basis of acetylation inhibition by PCN remains to be further explored.RESULTSOur molecular dynamics simulations revealed that PCN binds to the cleft in FgGcn5 where histone H3 is bound, with key amino acid residues including Leu96 (L96), Arg121 (R121), Phe133 (F133), Tyr169 (Y169), and Tyr201 (Y201), preventing FgGcn5 from binding to histone H3 and affecting histone H3 from being acetylated. Experimental validation of key amino acid mutations further confirmed the impact of these mutations on the interaction of FgGcn5 with PCN and histone H3 peptide.CONCLUSIONIn summary, our study sheds light on the mechanism by which PCN inhibits the acetylation function of FgGcn5, providing a foundation for the development of drugs or fungicides targeting histone acetyltransferases. © 2024 Society of Chemical Industry.
First‐Principles Calculation of SnSe2 Material as Anode Material of Zinc Ion Battery
Authors: Zhong Ensong , Liu Wenbo 
Published: October 2024

ABSTRACTThe development of high‐performance ion battery anode materials is conducive to the rapid development of urban rail transit. Based on first‐principles calculations, this paper studies the potential performance of the recently discovered two‐dimensional material SnSe2 as a negative electrode for zinc ion batteries. By calculating the adsorption energy, the most stable adsorption configuration of Zn was determined. The band gap of intrinsic SnSe2 decreases after strain, which promotes the transition of carriers. The band gap opens after the strain occurs in the Zn adsorbed SnSe2 system (Zn‐SnSe2), which confirms the regulation of strain on the band gap. The lowest diffusion barrier of Zn is 0.083 eV. The theoretical zinc storage capacity is calculated to be 387.550 mAh/g. The calculation results provide theoretical parameters for the application of SnSe2 in ion batteries.