bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clues to recognition of fumarate hydratase‐deficient renal cell carcinoma: Findings from cytologic and limited biopsy samples
Authors: Shyu Irene , Mirsadraei Leili , Wang Xiaoyan , Robila Valentina , Mehra Rohit , McHugh Jonathan B. , Chen Ying‐Bei , Udager Aaron M. , Gill Anthony J. , Cheng Liang , Amin Mahul B. , Lin Oscar , Smith Steven Christopher 
Published: October 2018

BackgroundFumarate hydratase (FH)‐deficient renal cell carcinoma (RCC) is rare and highly aggressive and is believed to arise mostly in the setting of hereditary leiomyomatosis‐RCC syndrome with a germline mutation of FH. Because of the aggressiveness of these tumors and a frequent lack of ascertainable family history, these tumors may first present as metastases and be sampled by cytology. The cytologic findings of FH‐deficient RCC have not previously been reported.MethodsCytologic and limited biopsy samples from patients with FH‐deficient RCC were reviewed retrospectively.ResultsIn total, 24 cytologic and limited biopsy samples from 19 patients (6 women and 13 men; age range, 22‐69 years) who had FH‐deficient RCC and metastasis at presentation were evaluated. These included 21 cytology samples ranging from malignant effusions (n = 7) to metastases (n = 11), to samples of primary kidney tumors (n = 3). The samples exhibited cells, often in clusters and abortive papillae, with voluminous, finely vacuolated cytoplasm and large, pleomorphic nuclei with prominent, viral inclusion‐like nucleoli. A distinctive finding of peripheral cytoplasmic clearing frequently was apparent, and intranuclear cytoplasmic pseudoinclusions were less frequent. Of 7 cell block and biopsy samples, several of which represented sampling from the same patient, all demonstrated tissue fragments that had discernable morphologic patterns associated with FH‐deficient RCC, including tubulocystic and intracystic papillary growth.ConclusionsFeatures characteristic and suggestive of FH‐deficient RCC may be identified in cytologic and small biopsy samples. Although the current samples were identified retrospectively in well characterized cases of FH‐deficient RCC, the authors argue that, with appropriate clinical correlation, these features are sufficiently distinctive to trigger recognition and confirmatory workup.
Automated detection of cancer cells in effusion specimens by DNA karyometry
Authors: Böcking Alfred H. , Friedrich David , Meyer‐Ebrecht Dietrich , Zhu Chenyan , Feider Anna , Biesterfeld Stefan 
Published: October 2018

AbstractBackgroundThe average sensitivity of conventional cytology for the identification of cancer cells in effusion specimens is only approximately 58%. DNA image cytometry (DNA‐ICM), which exploits the DNA content of morphologically suspicious nuclei measured on digital images, has a sensitivity of up to 91% for the detection of cancer cells. However, when performed manually, to our knowledge to date, an expert needs approximately 60 minutes for the analysis of a single slide.MethodsIn the current study, the authors present a novel method of supervised machine learning for the automated identification of morphologically suspicious mesothelial and epithelial nuclei in Feulgen‐stained effusion specimens. The authors compared this with manual DNA‐ICM and a gold standard cytological diagnosis for 121 cases. Furthermore, the authors retrospectively analyzed whether the amount of morphometrically abnormal mesothelial or epithelial nuclei detected by the digital classifier could be used as an additional diagnostic marker.ResultsThe presented semiautomated DNA karyometric solution identified more diagnostically relevant abnormal nuclei compared with manual DNA‐ICM, which led to a higher sensitivity (76.4% vs 68.5%) at a specificity of 100%. The ratio between digitally abnormal and all mesothelial nuclei was found to identify cancer cell–positive slides at 100% sensitivity and 70% specificity. The time effort for an expert therefore is reduced to the verification of a few nuclei with exceeding DNA content, which to our knowledge can be accomplished within 5 minutes.ConclusionsThe authors have created and validated a computer‐assisted bimodal karyometric approach for which both nuclear morphology and DNA are quantified from a Feulgen‐stained slide. DNA karyometry thus increases the diagnostic accuracy and reduces the workload of an expert when compared with manual DNA‐ICM.
Human machine interfacing technique for diagnosis of ventricular arrhythmia using supervisory machine learning algorithms
Authors: Karnan Hemalatha , Natarajan Sivakumaran , Manivel Rajajeyakumar 
Published: October 2018

SummaryThe state of art to integrate bio‐signals with computer based diagnosis is taking dominance. The man‐machine interface is useful for early and immediate clinical interpretation. The electrocardiogram (ECG) signal plays a vital role in revealing the possible data towards categorizing normal and abnormal cardiac functioning. The fatal conditions exhibited by ventricular arrhythmias (VA) pose a remarkable change in the feature set of the ECG signals. In this work, a novel approach to segregate the superior feature toward the ventricular arrhythmias are extracted using feature ranking score algorithm (FRSA). The FRSA collects feature vectors in three different domains and ranks it to find out the more prevalent feature for diagnosis of VA. The Support Vector Machine (SVM) classifier is administered by supervisory machine learning optimization algorithm Mean Grey Wolf Optimization (MGWO). The performance estimates of SVM‐MGWO is compared for classification of VA signals with other optimization also like SVM‐Particle Swarm Optimization (SVM‐PSO) and SVM‐Grey Wolf Optimization (SVM‐GWO). The non‐parametric and parametric analysis evidently shows the improved performance of feature parameter estimates for classification. The accuracy of classification for SVM‐MGWO attains 100% for finding test data with VA at a minimal convergence iteration while comparing it with the other mentioned supervisory algorithms. The standard deviation during parametric analysis is negligible, which reveals the fact that reductant feature extracted and utilized for testing of ECG data is minimal. The performance estimates attained by the proposed algorithm shows the selection of optimal feature for the findings of VA through ECG. The man‐machine interface aides in the early diagnosis of ventricular arrhythmias using non‐invasive diagnosing tool, the ECG.
Case conceptualization from a process‐based and modular perspective: Rationale and application to mood and anxiety disorders
Authors: Philippot Pierre , Bouvard Martine , Baeyens Céline , Dethier Vincent 
Published: October 2018

AbstractThis article presents the theoretical, clinical, and practical arguments supporting a process‐based transdiagnostic approach to psychotherapy. A working definition of “psychological process” is provided, as well as a tri‐dimensional categorization of psychological processes potentially involved in psychopathology. Guidelines are proposed to select psychological interventions based on the active psychopathological processes evidenced in a given case. We also provide a rationale to organize treatment as a set of modules, each addressing a specific psychopathological process. Next, we review the main processes that may be active in mood and anxiety disorders, and that are accessible to clinicians in regular practice. For each process, we propose a validated assessment questionnaire. Finally, we offer a free‐access web‐based instrument that allows clients to fill in these questionnaires via an internet survey, and that provides therapists with a tool to easily decode and interpret the questionnaire results and to present them to the clients.
Hydrologic responses to climate warming for a snow‐dominated watershed and a transient snow watershed in the California Sierra
Authors: Son Kyongho , Tague Christina 
Published: October 2018

AbstractClimate warming will have substantial impacts on hydrological fluxes in the California Sierra. A commonly used approach for assessing these impacts, particularly in mountain watersheds, is to substitute space for time. This conceptual model assumes that with warming, the hydrologic behaviour of higher elevation snow dominated watersheds (SDWs) will converge to the hydrologic behaviour of lower elevation transient snow watersheds (TSWs). To investigate the efficacy of this conceptual model, a process‐based model (RHESSys) was applied to a TSW and a SDW with a mean annual temperature 2 °C lower than the TSW in the Sierra National forest, California. This study investigated the effect of climate warming (2 and 4 °C) on the model estimates of snow water equivalent (SWE), streamflow, evapotranspiration (ET), and moisture deficit in the two watersheds. Modelling results show that SDW under 2 °C warming scenarios generates monthly SWE similar in magnitude and timing as TSW under historic conditions. However, SDW under 2 °C warming scenarios generates higher annual and summer streamflow due to shallower groundwater storage and experiences less water limitation due to lower ET, compared with TSW under historical climate conditions. In both watersheds, leaf area index and wetness index are primary factors controlling spatial patterns of seasonal ET under both historical climate conditions and warming scenarios. Climate warming increases the spatial variability in monthly ET, especially in the summer period. These modelling results suggest that vegetation structure and subsurface properties may be as important as climate in explaining hydrologic response to climate warming in small Sierra Nevada watersheds.
Evaluation of physicochemical properties and enzymatic activity of organic substrates during four crop cycles in soilless containers
Authors: Guerra Pedro A. Mejia , Salas Sanjúan Maria del Carmen , López Maria J. 
Published: October 2018

AbstractBackgroundOrganic soilless production in containers requires substrates with appropriate physicochemical and biological properties to ensure that production is sustainable and profitable for several production cycles. The main objective of this study was to comprehensively evaluate these properties in three different mixtures of organic substrates (vermicompost [V] and coconut fibers [CF] in ratios 20V80CF, 40V60CF, 60V40CF) for four horticultural crop production cycles (PCs) using vermicompost tea (VT) as the main source of nutrients.ResultsReadily available water (25%) in the control treatment (20V80CF) was below the recommended limit, and dry bulk density (>450 g/L) surpassed the recommended limit in the 60V40CF treatment (p < 0.05). In terms of chemical properties, cations and anions in the saturated media extract decreased significantly to values below established optimal conditions. Furthermore, the substrates presented high enzymatic activity in successive production cycles (p < 0.05), including dehydrogenase (350–400 μg TFF g−1), acid phosphatase (4,700 μg p‐nitrophenol g−1 soil hr−1), and β‐glucosidase (1,200 μg p‐nitrophenol g−1 soil hr−1) activity during transformation from organic matter to inorganic compounds.ConclusionThe 40V60CF treatment presents adequate physicochemical and biological characteristics for reuse for more than four growing cycles when organic supplements are administered.
Effect of chlorogenic acids on fatigue and sleep in healthy males: A randomized, double‐blind, placebo‐controlled, crossover study
Authors: Ochiai Ryuji , Tomonobu Kazuichi , Ikushima Ippei 
Published: October 2018

AbstractChlorogenic acids (CGAs) are found in abundance in coffee beans and have numerous health benefits. This study investigated the effect of CGAs extracted from coffee beans on fatigue and sleep in healthy participants. This crossover study involved 16 men (aged 30–54 years) who were daytime workers with weekends off work. The participants were randomized into two groups: One group was given a placebo beverage, and the other was given an active beverage containing 300 mg of CGAs. The test beverages were consumed for 13 days starting on a Sunday. The evaluation criteria were feelings of fatigue and sleep quality, sleep‐related indices recorded by an activity meter, and biomarkers. Feelings of fatigue and sleep‐related indices during the first (first half of week 1) and second (second half of week 2) halves of the consumption periods were compared. Within the first half of week 1, no differences in feelings of fatigue were observed between the groups. However, during the second half of week 2, fatigue upon awakening and sleep quality in the active group were significantly improved compared with those in the placebo group. Sleep efficiency and total nocturnal awakening time were significantly deteriorated in the second half of week 2 compared with the first half of week 1 in the placebo group. Furthermore, significant differences in these indices were observed between the two groups in the second half of week 2. These results suggest that the daily consumption of CGA‐containing beverages may improve fatigue upon awakening and sleep quality.
Exploring the relative efficacy of motion artefact correction techniques for EEG data acquired during simultaneous fMRI
Authors: Daniel Alexander J. , Smith James A. , Spencer Glyn S. , Jorge João , Bowtell Richard , Mullinger Karen J. 
Published: October 2018

AbstractSimultaneous EEG‐fMRI allows multiparametric characterisation of brain function, in principle enabling a more complete understanding of brain responses; unfortunately the hostile MRI environment severely reduces EEG data quality. Simply eliminating data segments containing gross motion artefacts [MAs] (generated by movement of the EEG system and head in the MRI scanner's static magnetic field) was previously believed sufficient. However recently the importance of removal of all MAs has been highlighted and new methods developed. A systematic comparison of the ability to remove MAs and retain underlying neuronal activity using different methods of MA detection and post‐processing algorithms is needed to guide the neuroscience community. Using a head phantom, we recorded MAs while simultaneously monitoring the motion using three different approaches: Reference Layer Artefact Subtraction (RLAS), Moiré Phase Tracker (MPT) markers and Wire Loop Motion Sensors (WLMS). These EEG recordings were combined with EEG responses to simple visual tasks acquired on a subject outside the MRI environment. MAs were then corrected using the motion information collected with each of the methods combined with different analysis pipelines. All tested methods retained the neuronal signal. However, often the MA was not removed sufficiently to allow accurate detection of the underlying neuronal signal. We show that the MA is best corrected using the RLAS combined with post‐processing using a multichannel, recursive least squares (M‐RLS) algorithm. This method needs to be developed further to enable practical utility; thus, WLMS combined with M‐RLS currently provides the best compromise between EEG data quality and practicalities of motion detection.
Excess influenza hospital admissions and costs due to the 2009 H1N1 pandemic in England
Authors: Lau Krystal , Hauck Katharina , Miraldo Marisa 
Published: October 2018

AbstractInfluenza pandemics considerably burden affected health systems due to surges in inpatient admissions and associated costs. Previous studies underestimate or overestimate 2009/2010 influenza A/H1N1 pandemic hospital admissions and costs. We robustly estimate overall and age‐specific weekly H1N1 admissions and costs between June 2009 and March 2011 across 170 English hospitals. We calculate H1N1 admissions and costs as the difference between our administrative data of all influenza‐like‐illness patients (seasonal and pandemic alike) and a counterfactual of expected weekly seasonal influenza admissions and costs established using time‐series models on prepandemic (2004–2008) data.We find two waves of H1N1 admissions: one pandemic wave (June 2009–March 2010) with 10,348 admissions costing £20.5 million and one postpandemic wave (November 2010–March 2011) with 11,775 admissions costing £24.8 million. Patients aged 0–4 years old have the highest H1N1 admission rate, and 25‐ to 44‐ and 65+‐year‐olds have the highest costs. Our estimates are up to 4.3 times higher than previous reports, suggesting that the pandemic's burden on hospitals was formerly underassessed. Our findings can help hospitals manage unexpected surges in admissions and resource use due to pandemics.
The early‐warning system of stock market crises with investor sentiment: Evidence from China
Authors: Zhang Rengui , Xian Xueshen , Fang Haowen 
Published: October 2018

AbstractUsing a database of the trading data in the Chinese stock market over January 2005 to June 2012, this paper studies the stock market crisis based on the perspective of behavioural finance. Investor sentiment is based on B‐W method, and the possibility of the Shanghai stock market crisis was predicted by the logit model. The empirical results show that investor sentiment, which is more significant than the macroeconomic variables, has a significant positive impact on stock market crisis after controlling for the economic variables. Moreover, our results offer an empirical explanation for the financial anomaly of mean reversion. Both in‐sample and out‐sample data tests show that the logit model with investor sentiment is able to predict stock crises.
EARLY MALTREATMENT AND CURRENT QUALITY OF RELATIONAL CARE PREDICT SOCIOEMOTIONAL PROBLEMS AMONG INSTITUTIONALIZED INFANTS AND TODDLERS
Authors: Baptista Joana , Silva Joana R. , Marques Sofia , Martins Carla , Soares Isabel 
Published: October 2018

ABSTRACTThe present study is focused on child socioemotional problems 6 months after institutionalization, by considering the putative predictive role of child maltreatment, of developmental functioning at admission and the following months, and of the quality of institutional relational care. Fifty institutionalized infants and toddlers participated in this study. Child developmental functioning (i.e., cognitive, language, and motor development) was assessed at admission to the institution (Wave 0), and 3 (Wave 1) and 6 months (Wave 2) thereafter. The quality of institutional relational care—operationalized in terms of caregivers’ sensitivity and cooperation—was measured at Wave 2. Caregivers reported on the presence of disturbed socioemotional behaviors at Wave 2. Child gestational age, birth weight, age, and stunted growth at admission to the institution served as covariates. Results revealed significant associations between socioemotional difficulties and lower levels of motor development at Waves 0 and 1, child maltreatment, and less sensitive caregiving. A logistic regression showed that child maltreatment and caregiver insensitivity were the only significant predictors of disturbed socioemotional functioning by the end of 6 months of institutionalization.
DOES A PERINATAL PARENTING INTERVENTION WORK FOR FATHERS? A RANDOMIZED CONTROLLED TRIAL
Authors: Mihelic Mandy , Morawska Alina , Filus Ania 
Published: October 2018

ABSTRACTFathers are increasingly expected to contribute to their parenting role at the transition to parenthood; however, many fathers experience mental health problems during this time. Parenting support for new fathers is limited, and research often only includes the mothers in intervention studies. Clear evidence for parenting programs for fathers has not yet been established. This study evaluated the effects of a parenting intervention (Baby Triple P) on fathers who were expecting their first baby. The design was a randomized controlled trial comparing Baby Triple P with care as usual over three time points (pregnancy, 10 weeks’ postbirth, and 6 months’ postbirth) for 112 fathers living in Brisbane, Australia. The primary outcomes included paternal psychological distress such as depression, anxiety, and stress and several secondary measures. No significant intervention effects for Baby Triple P were found at either post‐ or follow‐up assessments. Fathers in both groups reported significant increases in their parenting confidence and self‐efficacy. The results indicate no conclusive evidence for the effectiveness of Baby Triple P for new fathers. Future research using a sample with greater likelihood of experiencing problems at the transition to parenthood is needed as is offering more tailored need‐based support to obtain substantial evidence for this preventative parenting program.
Surface assembly of poly(I:C) on polyethyleneimine‐modified gelatin nanoparticles as immunostimulatory carriers for mucosal antigen delivery
Authors: Lin Shen‐Fu , Jiang Ping‐Lun , Tsai Jeng‐Shiang , Huang Yi‐You , Lin Shyr‐Yi , Lin Jiunn‐Horng , Liu Der‐Zen 
Published: October 2018

AbstractThe mucosal immune system is the host's first line of defense against invasion by foreign pathogens. Gelatin nanoparticles (GNPs) are suitable carriers for the delivery of antigens via various routes of administration. In the present study, GNPs were modified with polyethyleneimine (PEI), a positively charged polymer. Then, ovalbumin (OVA) and polyinosinic:polycytidylic acid (poly(I:C)), an immunostimulant, were adsorbed onto the surface of the positively charged GNPs. We assessed whether GNPs could act as an effective mucosal vaccine that is capable of inducing both mucosal and systemic immune responses. The results showed that GNPs effectively adsorbed OVA/poly(I:C), facilitated cellular uptake by RAW 264.7 macrophage cells and murine bone marrow‐derived dendritic cells (BMDCs) in vitro, and led to increased expression of the maturation markers CD80 and CD86 on BMDCs. Furthermore, GNPs induced increased secretion of proinflammatory cytokines in both RAW 264.7 and BMDCs. C57BL/6 mice that were intranasally twice‐immunized with OVA/poly(I:C)‐loaded GNPs produced high levels of serum OVA‐specific IgG antibodies and secretory IgA in nasal and lung lavage. Spleen cells from immunized mice were collected and re‐stimulated with OVA, and results showed significantly augmented production of IFN‐γ, IL‐4, IL‐5, and IL‐6 in mice that received OVA/poly(I:C)‐loaded GNPs. Moreover, intranasal immunization with OVA/poly(I:C)‐loaded GNPs resulted in the inhibition of EG7 tumor growth in C57BL/6 mice. Taken together, these results indicate that nasal administration of OVA/poly(I:C)‐loaded GNPs elicited effective mucosal and systemic immune responses, which might be useful for further applications of antigen delivery. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 107B: 1228–1237, 2019.
Plasmon‐enhanced inelastic scattering by 2D and 3D superlattices made of silver nanocrystals
Authors: Courty Alexa , Bayle Maxime , Carles Robert 
Published: October 2018

AbstractThe lattice dynamics of natural crystals, artificial superlattices, or self‐organized nanocrystals intimately mix confinement, coupling, periodicity, and dissipative effects. The low wavenumber vibrational response of the new class of nanomaterials called “supercrystals” does contain relevant information concerning finite size effects on atomic movements inside each nanocrystal, mechanical coupling between adjacent nanocrystals, coherent behavior of the total assembly due to its superperiodicity, and finally finite‐time effects due to damping. All these aspects concerning the dynamical behavior of silver supercrystals has been analyzed using plasmon resonance Raman scattering. Owing to the highly uniform size and chemical environment of the nanocrystals, the confinement and homogeneous damping of their fundamental vibrations are carefully analyzed. The signature of their internal atomic arrangements, as a reminiscence of bulk phonons, is also explored. It is shown that for low particles diameter (≲5 nm), deviations from the continuum elastic approximation occur and that the vibrational response is more sensitive to atomic arrangements and surface effects inside the nanocrystals than to spatial coherence effects between them.