bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association of daily physical activity with pulmonary artery pressure in HFpEF and HFmrEF NYHA class III patients: a pilot trial—feasibility and first results
Authors: Herrmann Ester J. , Lange Denise , Hannig Jennifer , Zimmer Gina , Gruen Dimitri , Keller Till , Edegran Albin , Johnson Linda S. , Sossalla Samuel , Guckert Michael , Assmus Birgit 
Published: November 2024

Abstract
Introduction
Supervised physical exercise has been shown to benefit patients with heart failure with preserved/mildly reduced ejection fraction (HFpEF/HfmrEF) by improving symptoms and diastolic function. This study aimed to investigate the correlation between unsupervised daily physical activity and changes in daily pulmonary artery pressure (PAP) in patients with stable NYHA class III heart failure (HF) and left ventricular ejection fraction (LVEF) of 45% or higher.

Methods
Daily physical activity was monitored over a 3-month period using a Holter-ECG with an accelerometer that calculated an activity-associated, heart rate-derived metabolic equivalent of task (MET) score. PAP was measured using an implanted sensor in 17 patients.

Results
During 3 months of PAP monitoring in parallel with Holter ECG in our HF patients (median age 77 [IQR 72–79.5] years, LVEF 55 [49–56] %, mean cardiac index 1.9 ± 0.3), mean, diastolic, and systolic PAP remained unchanged. Patients engaged in unsupervised daily activity with a mean MET score of 5.0 ± 1.2 and a median daily duration of 41 [13–123] minutes. Intensity of daily activity was associated with a higher diastolic PAP on the following day (R2 = 0.017, p = 0.003), particularly in female patients and those with pulmonary hypertension (PH) (female: R2 = 0.044, p = 0.002; PH: R2 = 0.024, p = 0.004). Patients with longer daily activity durations had lower systolic and mean PAP (p = 0.038 and p = 0.048) and a similar diastolic PAP (p = 0.053) after 3 months.

Conclusions
Tracking changes in daily PAP based on intensity and duration of unsupervised daily activity using implanted sensors and a PocketECG® is feasible. While daily activity duration was not directly linked to diastolic PAP on the first day after daily activity, intensity, especially in female and PH patients, was associated with increased diastolic PAP. In addition, longer daily activity, rather than higher intensity, might be more important for lowering PAP in the long term. Further research in larger trials is warranted to confirm these findings.
On the Laplace equation on bounded subanalytic manifolds
Authors: Valette Guillaume 
Published: November 2024

AbstractWe prove a trace formula for integration by parts on subanalytic bounded submanifolds of $${\mathbb {R}}^n$$

R

n

, possibly non closed. We also establish density results for $${\textbf{W}}^{1,p}_\nabla (M)$$

W

∇

1
,
p

(
M
)

, M bounded subanalytic manifold, which is the space of the $$L^p$$

L
p

tangent vector fields v on M for which $$\nabla v$$

∇
v

is $$L^p$$

L
p

, where $$\nabla $$
∇
is the divergence operator. We derive from these results some theorems of existence and uniqueness of solutions of the Laplace equation with Dirichlet and Neumann boundary type conditions. We then study the p-Laplace equation, for $$p\in [1,\infty )$$

p
∈
[
1
,
∞
)

large.
Gabor Phase Retrieval via Semidefinite Programming
Authors: Jaming Philippe , Rathmair Martin 
Published: November 2024

AbstractWe consider the problem of reconstructing a function $$f\in L^2({\mathbb R})$$

f
∈

L
2

(
R
)

given phase-less samples of its Gabor transform, which is defined by $$\begin{aligned} {\mathcal {G}}f(x,y) :=2^{\frac{1}{4}} \int _{\mathbb R}f(t) e^{-\pi (t-x)^2} e^{-2\pi i y t}\,\text{ d }t,\quad (x,y)\in {\mathbb R}^2. \end{aligned}$$

G
f

(
x
,
y
)

:
=

2

1
4

∫
R

f

(
t
)

e

-
π

(
t
-
x
)

2

e

-
2
π
i
y
t

d

t
,

(
x
,
y
)

∈

R

2

.

More precisely, given sampling positions $$\Omega \subseteq {\mathbb R}^2$$

Ω
⊆

R

2

the task is to reconstruct f (up to global phase) from measurements $$\{|{\mathcal {G}}f(\omega )|: \,\omega \in \Omega \}$$

{
|
G
f
(
ω
)
|
:

ω
∈
Ω
}

. This non-linear inverse problem is known to suffer from severe ill-posedness. As for any other phase retrieval problem, constructive recovery is a notoriously delicate affair due to the lack of convexity. One of the fundamental insights in this line of research is that the connectivity of the measurements is both necessary and sufficient for reconstruction of phase information to be theoretically possible. In this article we propose a reconstruction algorithm which is based on solving two convex problems and, as such, amenable to numerical analysis. We show, empirically as well as analytically, that the scheme accurately reconstructs from noisy data within the connected regime. Moreover, to emphasize the practicability of the algorithm we argue that both convex problems can actually be reformulated as semi-definite programs for which efficient solvers are readily available. The approach is based on ideas from complex analysis, Gabor frame theory as well as matrix completion. As a byproduct, we also obtain improved truncation error for Gabor expensions with Gaussian generators.
Knockdown resistance in Stomoxys calcitrans stable fly populations on German dairy farms: kdr alleles explain susceptibility of individual flies to deltamethrin
Authors: Daher Ricarda , Krücken Jürgen , Bauer Burkhard , da Silva Virginia Maria Góes , Reissert Sophia , Weiher Wiebke , Nijhof Ard M. , Clausen Peter-Henning , Steuber Stephan 
Published: November 2024

AbstractThe stable fly, Stomoxys calcitrans, is a globally important pest causing stress, economic losses and transmission of pathogens in livestock. Control on commercial farms relies predominantly on the use of insecticides, with pyrethroids being the most frequently used class of insecticides in industrialised countries. Here, laboratory isolates were obtained from four dairy farms in Brandenburg (Germany) and tested for phenotypic resistance to deltamethrin in comparison to a susceptible reference isolate using topical application. Individual flies were subsequently genotyped using allele-specific real-time PCRs. Phenotypic resistance was observed in all four field isolates with resistance ratios between 46 and 119 compared to the susceptible laboratory strain. At position 1014 of the voltage-sensitive sodium channel, allele-specific PCRs detected the wild-type, kdr-his and kdr genotypes encoding leucine, histidine and phenylalanine, respectively. In the susceptible laboratory isolate, only the wild-type was identified. On the farms with very high LD50 values, the kdr variant was most prevalent and logistic regression analysis revealed that the kdr variant increased the odds to survive exposure to deltamethrin more than the kdr-his genotype. Flies carrying two resistance alleles were less susceptible than flies that also carried one wild-type allele. In three out of four field isolates, the allele frequencies were significantly different from the expectations of the Hardy–Weinberg equilibrium suggesting ongoing selection. The data show that the phenotype can be largely explained by the kdr genotype and represent high frequencies of the L1014F kdr and L1014H kdr-his variants conferring high levels of resistance in northern Germany.
Mixed method evaluation of factors influencing the adoption of organic participatory guarantee system certification among Vietnamese vegetable farmers
Authors: Tennhardt Lina M. , Home Robert , Yen Nguyen Thi Bich , Van Hoi Pham , Ferrand Pierre , Grovermann Christian 
Published: November 2024

AbstractIn markets where vegetables are commonly cultivated with heavy use of synthetic pesticides, it is particularly important for consumers to be able to identify genuine organic produce. Organic Participatory Guarantee Systems (PGS) certification offers smallholder farmers an affordable way to build trust among consumers and secure premium prices for their organic produce. In Vietnam, the demand for vegetables with no, or low, pesticide residues is growing. The attractiveness of PGS certification should increase accordingly, but the number of organic PGS certified farmers in Vietnam are stagnating or even decreasing. The aim of this study is to explain this paradox by investigating the factors that influence the adoption of organic PGS certification among Vietnamese vegetable farmers. We follow a mixed methods approach, combining a qualitative analysis of farmer interviews (n = 62) and a quantitative analysis of a farm survey data (n = 434) using a sample selection model that estimates adoption contingent on farmers’ awareness of PGS certification. Drawing on the Unified Theory of Acceptance and Use of Technology, we found that social relationships and positive attitudes towards farming and the environment drive the adoption of organic PGS. Barriers include insufficient knowledge of organic farming techniques, labour shortages, and ageing farmers. At the systemic level, support by (non-)governmental institutions facilitates adoption, but challenges such as lower yields and limited access to premium markets remain. To promote organic PGS among Vietnamese vegetable farmers, efforts should focus on disseminating organic farming techniques that boost yields, alleviate labour demands, and ensure secure markets for premium-priced organic vegetables.
Revisiting streaming anomaly detection: benchmark and evaluation
Authors: Cao Yang , Ma Yixiao , Zhu Ye , Ting Kai Ming 
Published: November 2024

AbstractAnomaly detection in streaming data is an important task for many real-world applications, such as network security, fraud detection, and system monitoring. However, streaming data often exhibit concept drift, which means that the data distribution changes over time. This poses a significant challenge for many anomaly detection algorithms, as they need to adapt to the evolving data to maintain high detection accuracy. Existing streaming anomaly detection algorithms lack a unified evaluation framework that validly assesses their performance and robustness under different types of concept drifts and anomalies. In this paper, we conduct a systematic technical review of the state-of-the-art methods for anomaly detection in streaming data. We propose a new data generator, called SCAR (Streaming data generator with Customizable Anomalies and concept dRifts), that can synthesize streaming data based on synthetic and real-world datasets from different domains. Furthermore, we adapt four static anomaly detection models to the streaming setting using a generic reconstruction strategy as baselines, and then compare them systematically with 9 existing streaming anomaly detection algorithms on 76 synthesized datasets that have various types of anomalies and concept drifts. The challenges and future research directions for anomaly detection in streaming data are also presented.
Pre-emergence herbicides used in urban and agricultural settings: dissipation and ecological implications
Authors: Parven Aney , Meftaul Islam Md , Venkateswarlu Kadiyala , Megharaj Mallavarapu 
Published: November 2024

AbstractHerbicides are widely recognized as the most cost-effective solution for weed control, but their extensive use in both urban and agricultural settings raise serious concerns about nontarget effects. We assessed the possible hazards associated with pre-emergence herbicides such as dimethenamid–P, metazachlor, and pyroxasulfone, which are frequently applied in both urban and agricultural soils. The dissipation rate constant values (k day−1: 0.010–0.024) were positively linked to total organic carbon (TOC), silt, clay, soil pH, and Al and Fe oxides, but negatively correlated with sand content. In contrast, half-life values (DT50: 29–69 days) of the herbicides showed negative correlations with TOC, clay, silt, soil pH, and Fe and Al oxides, while sand content showed a positive impact. The selected herbicides showed minimal impact on soil dehydrogenase activity (DHA). Mostly, soils with higher organic matter (OM) content exhibited increased DHA levels, highlighting the role of OM in influencing this soil enzyme across different soils. Assessment of environmental indicators like groundwater ubiquity score (GUS:1.69–6.30) and leachability index (LIX: 0.23–0.97) suggested that the herbicides might reach groundwater, posing potential risks to nontarget biota and food safety. Human non-cancer risk evaluation, in terms of hazard quotient (HQ < 1) and hazard index (HI < 1), suggests minimal or no risks from exposure to soil containing herbicide residues at 50% of the initial concentrations. Our data thus help the stakeholders and regulatory agencies while applying these pre-emergence herbicides in soils and safeguarding human and environmental health.
Unconditional basic sequences in function spaces with applications to Orlicz spaces
Authors: Ansorena José L. , Bello Glenier 
Published: November 2024

Abstract
We find conditions on a function space

$${\varvec{L}}$$

L

that ensure that it behaves as an

$$L_p$$

L
p

-space in the sense that any unconditional basis of a complemented subspace of

$${\varvec{L}}$$

L

either is equivalent to the unit vector system of

$$\ell _2$$

ℓ
2

or has a subbasis equivalent to a disjointly supported basic sequence. This dichotomy allows us to classify the symmetric basic sequences of

$${\varvec{L}}$$

L

. Several applications to Orlicz function spaces are provided.
Estimated frequency and economic burden of incident fragility fractures during 2023 in Mexico
Authors: Carlos-Rivera Fernando , Guzmán-Caniupan Jorge Antonio , Camacho-Cordero Luis Miguel , Aubry de Maraumont Therese , Soria-Suárez Noe 
Published: November 2024

Abstract

Summary

Epidemiologic and economic data regarding osteoporotic fractures in Mexico is scarce and mostly outdated. Through a model, we estimated the incidence and costs of osteoporotic fractures in adults ≥ 50 years old in Mexico during the year 2023. Results showed that these events are both frequent and costly, leading to a considerable economic impact.

Purpose
Osteoporosis and its fractures impose a high clinical and economic burden. The objective of this analysis was to estimate the frequency and costs owing to incident fragility fractures (FFs) during the year 2023 in Mexico.

Methods
This is an incidence-based cost-of-illness study. The target population is adults ≥ 50 years old sustaining a fracture related to osteoporosis (caused by a fall on the same level). The model estimates the costs and productivity losses associated with their treatment within 1 year post-fracture. National epidemiologic databases supplemented with information, derived from literature when appropriate, were used to estimate the frequency of new FFs during 2023 in the study population. Resource use included surgical and non-surgical inpatient or ambulatory care the patients received immediately after fracture plus the outpatient physiotherapy post-discharge and the eventual follow-up with a specialist who may prescribe pharmacotherapy. Sick days taken in employed patients were estimated from the literature. Local unitary costs of services and drugs for both public and private settings as well as average income in those occupied were applied. All costs are reported in Mexican pesos (MXN) from 2023.

Results
The model estimated a total of 229,239 FFs, among which 63% were classified as a major osteoporotic fracture, including 53,842 and 41,459 fractures located at the hip and vertebral, respectively. The total costs were estimated at 15,593 million MXN; most of them (75.2%) were attributable to acute-phase care.

Conclusions
Fragility fractures represent a serious health problem for Mexico. Better preventive/therapeutic strategies may help to mitigate their significant financial toll.
Association of High-Sensitivity C-Reactive Protein (hs-CRP) with Weight Loss After Sleeve Gastrectomy and Roux-en-Y Gastric Bypass at 10 Years: A Secondary Analysis of the SLEEVEPASS Randomized Clinical Trial
Authors: Saarinen Ilmari , Strandberg Marjatta , Hurme Saija , Grönroos Sofia , Juuti Anne , Helmiö Mika , Salminen Paulina 
Published: November 2024

Abstract
Background
Severe obesity is associated with a low-grade chronic inflammation, and high-sensitivity C-reactive protein (hs-CRP) is a marker that can be used to evaluate chronic inflammation status. Metabolic bariatric surgery (MBS) is shown to decrease hs-CRP level, but long-term results are scarce, and association with weight loss outcomes is undetermined. This study aims to evaluate chronic inflammation in patients with obesity using hs-CRP, and its association with long-term weight loss outcomes after laparoscopic sleeve gastrectomy (LSG) and laparoscopic Roux-en-Y gastric bypass (LRYGB).

Methods
The long-term follow-up data of SLEEVEPASS (ClinicalTrials.gov NCT00793143) randomized clinical trial (RCT) was used. Hs-CRP was measured at baseline, and at 6 months, 1, 3, 5, 7, and 10 years after surgery, and the association with weight and weight loss outcomes were analyzed.

Results
Hs-CRP at baseline was available for 59 out of 240 (24.6%) patients. In the whole study population, the nadir hs-CRP (mean estimate 1.14 mg/ml, 95% CI 0.87–1.49) was achieved at 3 years after surgery with a statistically significant difference to baseline (p = 0.003). No statistically significant difference was seen between LSG and LRYGB in hs-CRP change over time (operation*time interaction p = 0.540). Higher hs-CRP correlated with higher BMI at baseline (Spearman correlation 0.282, p = 0.030) and at 10 years (Spearman correlation 0.490, p = 0.001). At 10 years, a greater percentage total weight loss (%TWL) correlated with lower hs-CRP level (Spearman correlation − 0.558, p < 0.001). Baseline hs-CRP (Spearman correlation − 0.152, p = 0.299) and hs-CRP change in first 6 months postoperatively (Spearman correlation 0.167, p = 0.254) did not correlate statistically significantly with %TWL at 10 years.

Conclusions
MBS decreases hs-CRP also at long-term follow-up with weight loss as the driving force. Neither baseline hs-CRP nor hs-CRP change at 6 months were feasible as a predictive marker for long-term outcomes.
Regularity of the minmax value and equilibria in multiplayer Blackwell games
Authors: Ashkenazi-Golan Galit , Flesch János , Predtetchinski Arkadi , Solan Eilon 
Published: November 2024

AbstractA real-valued function φ that is defined over all Borel sets of a topological space is regular if for every Borel set W, φ(W) is the supremum of φ(C), over all closed sets C that are contained in W, and the infimum of φ(O), over all open sets O that contain W.We study Blackwell games with finitely many players. We show that when each player has a countable set of actions and the objective of a certain player is represented by a Borel winning set, that player’s minmax value is regular.We then use the regularity of the minmax value to establish the existence of ε-equilibria in two distinct classes of Blackwell games. One is the class of n-player Blackwell games where each player has a finite action space and an analytic winning set, and the sum of the minmax values over the players exceeds n − 1. The other class is that of Blackwell games with bounded upper semi-analytic payoff functions, history-independent finite action spaces, and history-independent minmax values. For the latter class, we obtain a characterization of the set of equilibrium payoffs.
Multi-Omics Approach Reveals Genes and Pathways Affected in Miller-Dieker Syndrome
Authors: Mahendran Gowthami , Breger Kurtis , McCown Phillip J. , Hulewicz Jacob P. , Bhandari Tulsi , Addepalli Balasubrahmanyam , Brown Jessica A. 
Published: November 2024

AbstractMiller-Dieker syndrome (MDS) is a rare neurogenetic disorder resulting from a heterozygous deletion of 26 genes in the MDS locus on human chromosome 17. MDS patients often die in utero and only 10% of those who are born reach 10 years of age. Current treatments mostly prevent complications and control seizures. A detailed understanding of the pathogenesis of MDS through gene expression studies would be useful in developing precise medical approaches toward MDS. To better understand MDS at the molecular level, we performed RNA sequencing on RNA and mass spectrometry on total protein isolated from BJ (non-MDS) cells and GM06097 (MDS) cells, which were derived from a healthy individual and an MDS patient, respectively. Differentially expressed genes (DEGs) at the RNA and protein levels involved genes associated with phenotypic features reported in MDS patients (CACNG4, ADD2, SPTAN1, SHANK2), signaling pathways (GABBR2, CAMK2B, TRAM-1), and nervous system development (CAMK2B, BEX1, ARSA). Functional assays validated enhanced calcium signaling, downregulated protein translation, and cell migration defects in MDS. Interestingly, overexpression of methyltransferase-like protein 16 (METTL16), a protein encoded in the MDS locus, restored defects in protein translation, phosphor states of mTOR (mammalian target of rapamycin) pathway regulators, and cell migration in MDS cells. Although DNA- and RNA-modifying enzymes were among the DEGs and the intracellular SAM/SAH ratio was eightfold lower in MDS cells, global nucleoside modifications remained unchanged. Thus, this study identified specific genes and pathways responsible for the gene expression changes, which could lead to better therapeutics for MDS patients.
A new species of Fissidentalium (Scaphopoda: Dentaliidae) in association with an actinostolid anemone from the abyssal Labrador Sea
Authors: Linse Katrin , Neuhaus Jenny 
Published: November 2024

AbstractThe benthic biodiversity of the abyssal Labrador Sea was investigated using Agassiz trawl and in situ imagery. A megafaunal scaphopod associated with an epizoic anemone was recovered from soft sediments. Morphological and molecular investigations revealed the scaphopod to be an undescribed species in the dentaliid genus Fissidentalium P. Fischer, 1885. The new scaphopod species is characterised by a large size for the genus, is moderately curved, with numerous narrow, longitudinal ribs (60 ribs at 11 mm diameter ventral aperture), a dentaliid radula, and is described herein as Fissidentalium aurae sp. nov. The new species shows a close genetic relationship to congeners of Fissidentalium and separates from the sister genera Dentalium Linnaeus, 1758 and Antalis H. Adams & A. Adams, 1854. Genetic COI barcoding of the epizoic anemone suggests the species is a member of the family Actinostolidae Carlgren, 1932. The discovered association of a burrowing scaphopod with an epifaunal anemone at abyssal depth is a new record for the region and is indicative of how little is known about symbioses in the deep sea.
Comprehensive study on statistical methods for optimization of process parameters and material properties of AlSi10Mg in laser powder bed fusion
Authors: Krasniqi Mergim , Löffler Frank 
Published: November 2024

AbstractThis study provides a systematic investigation of the effects of process parameters and heat treatments on the material properties of AlSi10Mg, produced by laser powder bed fusion (L-PBF). Using a central composite design (CCD) with 106 test specimens (49 cubes, 57 tensile), the samples were studied for key properties: density (up to 99.96%), hardness (up to 154.6 HV1), surface roughness (as low as 1.9 Ra), tensile strength (up to 487.5 MPa), and elongation at break (up to 16.6%). Statistical analysis (ANOVA) identified laser power and scanning speed as the most influential parameters on these properties. Additionally, heat treatment was shown to reduce hardness and tensile strength but increase elongation at break, demonstrating the ability to modify mechanical properties based on the desired outcome. Process parameter optimization yielded properties comparable to some of the highest reported values for AlSi10Mg in the literature. The study also discusses the transferability and reproducibility of L-PBF results across different machines, highlighting challenges related to machine-to-machine variations, lack of calibration and standardization and parameter consistency. The results demonstrate the potential of L-PBF to produce AlSi10Mg parts with tailored properties for industrial applications.