bluuebunny/crossref_metadata_2025_split huggingface dataset:
Navigating from cellular phenotypic screen to clinical candidate: selective targeting of the NLRP3 inflammasome
Authors: Matico Rosalie , Grauwen Karolien , Chauhan Dhruv , Yu Xiaodi , Abdiaj Irini , Adhikary Suraj , Adriaensen Ine , Aranzazu Garcia Molina , Alcázar Jesus , Bassi Michela , Brisse Ellen , Cañellas Santiago , Chaudhuri Shubhra , Delgado Francisca , Diéguez-Vázquez Alejandro , Du Jardin Marc , Eastham Victoria , Finley Michael , Jacobs Tom , Keustermans Ken , Kuhn Robert , Llaveria Josep , Leenaerts Jos , Linares Maria Lourdes , Martín Maria Luz , Martín-Pérez Rosa , Martínez Carlos , Miller Robyn , Muñoz Frances M , Muratore Michael E , Nooyens Amber , Perez-Benito Laura , Perrier Mathieu , Pietrak Beth , Serré Jef , Sharma Sujata , Somers Marijke , Suarez Javier , Tresadern Gary , Trabanco Andres A , Van den Bulck Dries , Van Gool Michiel , Van Hauwermeiren Filip , Varghese Teena , Vega Juan Antonio , Youssef Sameh A , Edwards Matthew J , Oehlrich Daniel , Van Opdenbosch Nina 
Published: December 2024

Abstract
The NLRP3 inflammasome plays a pivotal role in host defense and drives inflammation against microbial threats, crystals, and danger-associated molecular patterns (DAMPs). Dysregulation of NLRP3 activity is associated with various human diseases, making it an attractive therapeutic target. Patients with NLRP3 mutations suffer from Cryopyrin-Associated Periodic Syndrome (CAPS) emphasizing the clinical significance of modulating NLRP3. In this study, we present the identification of a novel chemical class exhibiting selective and potent inhibition of the NLRP3 inflammasome. Through a comprehensive structure–activity relationship (SAR) campaign, we optimized the lead molecule, compound A, for in vivo applications. Extensive in vitro and in vivo characterization of compound A confirmed the high selectivity and potency positioning compound A as a promising clinical candidate for diseases associated with aberrant NLRP3 activity. This research contributes to the ongoing efforts in developing targeted therapies for conditions involving NLRP3-mediated inflammation, opening avenues for further preclinical and clinical investigations.
High-pressure phase transition and amorphization of BaV2O6
Authors: Zhang Peijie , Botella Pablo , Bura Neha , Rodrigo Jose-Luis , Sanchez-Martin Josu , Vie David , Popescu Catalin , Errandonea Daniel 
Published: December 2024

BaV2O6 undergoes a phase transition from the orthorhombic phase (space group C222) to a monoclinic phase (space group C2) above 4 GPa, driven by the distortion of the vanadium oxide polyhedron.
Face-controlled chirality induction in octahedral thiacalixarene-based porous coordination cages
Authors: Khariushin Ivan V. , Ovsyannikov Alexander S. , Baudron Stéphane A. , Ward Jas S. , Kiesilä Anniina , Rissanen Kari , Kalenius Elina , Chessé Matthieu , Nowicka Beata , Solovieva Svetlana E. , Antipin Igor S. , Bulach Véronique , Ferlay Sylvie 
Published: December 2024

Two pairs of enantiomers were obtained via self-assembly of sulfonylcalix[4]arene tetranuclear M(ii) clusters (M = Co or Ni) with enantiomerically enriched linkers based on tris(dipyrrinato)cobalt(iii) complexes, leading to nanosized porous cages.
Partial discharge characteristics of syntactic foam filled with hollow polymer microspheres
Authors: Li Le , Tan Shuo , Liu Yunpeng , Li Haoyi , Xu Kezhi , Zhen Guancheng , Yin Xiaoxuan , Zhao Tianfang , Wu Wenhua , Yang Lei 
Published: December 2024

AbstractSyntactic foam materials, due to their advantages of low densities, low water absorption, and high dielectric strengths, have significant application potential in the cores of post insulators. However, because of a large number of microbubble structures within the syntactic foam, it might decrease the partial discharge inception voltage. It is necessary to investigate the partial discharge characteristics of the foam to assess the feasibility of its internal insulation application. In this study, the syntactic foam samples with four different microsphere contents (0%–2%) were prepared, and the physical structures of the materials were characterised by using Fourier transform infrared spectroscopy, scanning electron microscopy, and three‐dimensional computed tomography. Subsequently, finite element simulations of the electric field were performed to analyse the influence of the microsphere content and distribution on the internal electric field of the syntactic foam. The results suggested that both the microsphere content and distribution affected the partial discharge activity. When the microsphere content was low, the doping of microspheres essentially meant that more air gap defects were present, leading to a decrease in the partial discharge performance. However, when the microsphere content was high, the microspheres were distributed in a dense and orderly manner, improving the field concentration phenomenon and hence inhibiting the partial discharge to a certain extent. In conclusion, the findings of this study provide a data reference and theoretical support for the application of syntactic foam in the cores of composite post insulators.
Evaluation of automated driving safety in urban mixed traffic environments
Authors: Lee Sangjae , Jo Young , Jung Aram , Park Juneyoung , Oh Cheol 
Published: December 2024

AbstractConflicting driving behaviours between automated vehicles and manually driven vehicles may compromise driving safety. The aim of this study is to analyse the safety of mixed traffic on urban roads. The driving simulation tests were conducted using a multi‐agent driving simulator, which allows real‐time synchronization of multiple simulators. These data were further processed to derive the driving behaviour parameters of manually driven vehicles in VISSIM traffic simulations. Driving safety evaluation indicators included conflict‐related indicators, as well as individual safety indicators. The safety evaluation indicators were normalized through min–max normalization, and the risk scores were summed to evaluate the urban roads. The analysis revealed that driving safety was poor at unsignalized intersections with a market penetration rate of 10% and 50% and at signalized intersections with traffic islands and a market penetration rate of 100%, where conflicts arise from the deceleration of leading vehicles and lane changes. This finding is about the driving behaviour of automated vehicles, which maintain a greater distance from the leading vehicle than manually driven vehicles, resulting in poorer driving safety due to lane changes rather than deceleration. Using the findings of this study, criteria for assessing the safety of mixed traffic situations in existing road infrastructures can be established.
HYPERION: Broad-band X-ray-to-near-infrared emission of quasars in the first billion years of the Universe
Authors: Saccheo I. , Bongiorno A. , Piconcelli E. , Zappacosta L. , Bischetti M. , D’Odorico V. , Done C. , Temple M. J. , Testa V. , Tortosa A. , Brusa M. , Carniani S. , Civano F. , Comastri A. , Cristiani S. , De Cicco D. , Elvis M. , Fan X. , Feruglio C. , Fiore F. , Gallerani S. , Giallongo E. , Gilli R. , Grazian A. , Guainazzi M. , Haardt F. , Maiolino R. , Menci N. , Miniutti G. , Nicastro F. , Paolillo M. , Puccetti S. , Salvestrini F. , Schneider R. , Tombesi F. , Tripodi R. , Valiante R. , Vallini L. , Vanzella E. , Vietri G. , Vignali C. , Vito F. , Volonteri M. , La Franca F. 
Published: December 2024

Aims. We aim to characterize the X-ray-to-optical/near-infrared(NIR) broad-band emission of luminous quasars (QSOs) in the first gigayear (Gyr) of cosmic evolution in order to decipher whether or not they exhibit differences compared to the lower-z QSO population. Our goal is also to provide a reliable and uniform catalog of derivable properties for these objects (from fitting their spectral energy distribution), such as bolometric and monochromatic luminosities, Eddington ratios, dust extinction, and the strength of the hot dust emission.
Methods. We gathered all available photometry –from XMM-Newton proprietary data in X-rays to rest-frame NIR wavelengths– for the 18 QSOs in the HYPERION samples (6.0 ≤ z ≤ 7.5). For sources lacking uniform NIR coverage, we conducted NIR observations in the J, H, and K bands. To increase the statistical robustness of our analysis across the UV-to-NIR region, we add 36 additional sources to our sample from the E-XQR-30 sample with 5.7 ≲ z ≲ 6.6. We characterized the X-ray/UV emission of each QSO using average SEDs from luminous Type 1 sources and calculated bolometric and monochromatic luminosities. Finally, we constructed a mean SED extending from the X-rays to the NIR bands.
Results. We find that the UV-optical emission of these QSOs can be modeled with templates of z ∼ 2 luminous QSOs. We observe that the bolometric luminosities derived while adopting some bolometric corrections at 3000 Å (BC3000 Å) largely used in the literature are slightly overestimated, by 0.13 dex, as they also include reprocessed IR emission. We estimate a revised value of BC3000 Å = 3.3, which can be used to derive Lbol in z ≥ 6 QSOs. We provide a subsample of 11 QSOs with rest-frame NIR photometry; these show a broad range of hot dust emission strength, with two sources exhibiting low levels of emission. Despite potential observational biases arising from nonuniform photometric coverage and selection biases, we produce an X-ray-to-NIR mean SED for QSOs at z ≳ 6 that is a good match to templates of lower-redshift, luminous QSOs up to the UV–optical range, with a slightly enhanced contribution from hot dust in the NIR.
Anti-Drug-Antikörper und der Einfluss von Methotrexat und Biologika-Applikationsintervall
Authors: Hinze Claas H. 
Published: December 2024

ZUSAMMENFASSUNGAnti-Drug-Antikörper (ADAbs) können die Therapieeffektivität biologischer krankheitsmodifizierender Antirheumatika (bDMARD) bei entzündlichen Arthropathien erheblich mindern. Mögliche ADAb-bedingte Probleme beinhalten u. a. einen sekundären Wirkverlust, einen rascheren Abbau des bDMARD und eine höhere Wahrscheinlichkeit für Hypersensitivitätsreaktionen. Das Risiko für die Bildung von ADAbs unterliegt vielen Einflussfaktoren und unterscheidet sich stark zwischen verschiedenen bDMARD. Generell besteht ein hohes Risiko besonders bei monoklonalen Antikörpern (MAbs), die gegen TNF gerichtet sind und ist niedriger bei MAbs, die nicht gegen TNF gerichtet sind und bei Fusionsproteinen. Eine begleitende Therapie mit MTX und anderen konventionell synthetischen (cs)DMARD mindert das Risiko der ADA-Bildung um etwa zwei Drittel bis drei Viertel. Längere Intervalle zwischen den Dosen der MAbs und auch eine niedrige MAb-Dosis könnten die ADAb-Bildung erhöhen, basierend auf der Diskontinuitätstheorie der Immunität. Die Bildung von ADAbs stellt einen komplexen immunologischen Prozess dar, der durch spezifische Epitope, Proteinstruktur, patientenspezifische Faktoren und Applikationsbedingungen beeinflusst wird. Nicht neutralisierende ADAbs können die Pharmakokinetik und Nebenwirkungen des Medikaments beeinflussen, während neutralisierende ADAbs zusätzlich direkt die Wirksamkeit des bDMARD inhibieren können. Therapeutisches Drug-Monitoring (TDM) ist eine Option, um Medikamentenspiegel zu überwachen und ggf. die Dosierung anzupassen, um die langfristige Wirksamkeit der Therapie zu sichern. Die klinische Relevanz von ADAbs, insbesondere bei Anti-TNF-MAbs, und Strategien zur Minimierung ihrer Bildung werden im Detail erörtert.
Ist die Steroidpulstherapie der konventionellen Hochdosissteroidtherapie überlegen?
Authors: Weller-Heinemann Frank 
Published: December 2024

ZUSAMMENFASSUNGSeit die Steroidpulstherapie vor ca. 50 Jahren als besondere Applikationsform von Glukokortikoiden eingeführt wurde, konnte sie in vielen Bereichen der Kinder- und Jugendmedizin mit teilweise großem Erfolg eingesetzt werden. Offenbar kommen andere Wirkmechanismen zur genomischen Wirkung der Glukokortikoide noch hinzu. Trotz der hohen Steroiddosis ist die Verträglichkeit vor allem bei Kindern überwiegend sehr gut. Da sie im Intervall von ca. 2–4 Wochen an je 3–5 Tagen durchgeführt wird, ist insbesondere die von Jugendlichen gefürchtete cushingoide Fazies weitgehend zu vermeiden. Direkte vergleichende Studien zur konventionellen oralen Steroidmedikation sind sehr selten; die überwiegende Zahl an Publikationen zur Steroidpulstherapie bezieht sich auf deren Indikation und Effektivität. Auch im Zeitalter der Biologika bleibt die Steroidpulstherapie ein wesentlicher Baustein einer antientzündlichen Therapie.
Update Mammakarzinom 2024 Teil 1 – Expertenmeinungen zu Brustkrebs in fortgeschrittenen Krankheitsstadien
Authors: Würstlein Rachel , Kolberg Hans-Christian , Hartkopf Andreas D. , Fehm Tanja N. , Welslau Manfred , Schütz Florian , Fasching Peter A. , Janni Wolfgang , Witzel Isabell , Thomssen Christoph , Krückel Annika , Belleville Erik , Lüftner Diana , Untch Michael , Thill Marc , Hörner Manuel , Tesch Hans , Ditsch Nina , Lux Michael P. , Aktas Bahriye , Banys-Paluchowski Maggie , Taran Florin-Andrei , Wöckel Achim , Harbeck Nadia , Stickeler Elmar , Bartsch Rupert , Schneeweiss Andreas , Ettl Johannes , Krug David , Müller Volkmar 
Published: December 2024

Klinische Evidenz wird auf Basis klinischer Studien und der persönlichen Erfahrung interpretiert. Dies kann in einer unterschiedlichen Deutung der Datenlage resultieren. Vor diesem Hintergrund sind Expertenpanels wie das Advanced Breast Cancer Panel, das im November 2023 zum 7. Mal zusammengekommen ist (ABC7), von besonderer Bedeutung. Aktuelle Themen werden von einem internationalen Expertenteam bewertet.Im Jahr 2023 scheint sich die Datenlage zu den CDK4/6-Inhibitoren so verdichtet zu haben, dass Fragen zur Sequenz und zu einer möglichen Chemotherapie als Alternative relativ klar beantwortet werden können. Des Weiteren sind für alle molekularen Subtypen Daten zu Antikörper-Wirkstoff-Konjugaten vorhanden, sodass ein gutes Bild über deren Einsatz entstanden ist. Einige Therapiesituationen sind nach wie vor von besonderer Bedeutung und sind strukturiert diskutiert worden, wie zum Beispiel Hirnmetastasen und leptomeningeale Erkrankung, ältere Patientinnen, das lokal fortgeschrittene Mammakarzinom und die viszerale Krise. Im Rahmen dieser Arbeit werden einige der diskutierten Themen im wissenschaftlichen Kontext dargestellt und bewertet.
When never meant ever
Authors: Pinto Clara 
Published: December 2024

Abstract
In European Portuguese, nunca ‘never’ is traditionally classified as a temporal adverb and it can
convey sentential negation on its own, therefore behaving as a strong negative polarity item (NPI). Nevertheless, in early stages
of the language we find nunca with a non-negative interpretation, in contexts that are considered ungrammatical
in contemporary Portuguese. Unlike negative indefinites that started as weak NPIs and became inherently negative,
nunca was already a strong negative polarity item in 13th century Portuguese. In this article I will show
that, apart from the strong NPI nunca, there was also an ambiguous item nunca that corresponded
to a modal polarity item. In the Romance context, items originating from Latin numquam also unfold into ambiguous
items with different polarity. In Portuguese, however, ambiguity was not preserved. The evolution of nunca
reinforces the idea that Portuguese is the most innovative of Romance languages regarding the outcomes of polarity items.
The influence of semantic primes on the typing of word targets
Authors: Mangat Ajay , Taikh Alexander 
Published: December 2024

Abstract
Typing is a complex activity involving identifying and encoding the to-be-typed word, planning, and executing the
keystrokes. Different mechanisms have been proposed to explain how contextual information about meaning influences the processing
of a target word (for example, semantic priming), and it is unclear how this information influences the typing output of the
target word. When the interval between the prime and target is short, the prime is thought to automatically activate the target.
With a longer interval, the facilitation may be more strategic. The influence of the prime on the output of the target may thus
depend on the interval between the two. We found that at both short and long intervals, related semantic primes facilitated the
speed of the first keystroke of the target word. However, there was no effect on how quickly the non-initial letters of the target
were entered, suggesting that information from semantic primes influences the planning and initiation of typing, but not the
execution of remaining keystrokes. Interestingly, the initial and non-initial keystrokes were faster when the interstimulus
interval was long, suggesting participants encode the letters of the prime which could interfere with encoding and typing the
target if the interval between them is short.
The acquisition of grammatical gender in child and adult heritage speakers of Spanish
Authors: Cuza Alejandro , Sánchez Liliana 
Published: December 2024

Abstract
Previous work on the acquisition of grammatical gender in child and adult heritage speakers of
Spanish has found significant mismatches in gender agreement stemming from overgeneralization of the masculine form to
contexts in which the feminine is required. It has been argued that these divergences stem from various sources
including incomplete acquisition during childhood (e.g. Montrul & Potowski,
2007; Montrul, Foote, & Perpiñan, 2008), form/meaning
mapping issues (e.g. Alarcón, 2011) or reconfiguration of gender features
(e.g. Cuza & Pérez-Tattam, 2016; Scontras, Polinsky, & Fuchs, 2018). The goal of the present chapter is to examine this previous work
on grammatical gender and the extent to which it can shed light on more recent proposals on heritage language
theorizing. We follow the Bilingual Alignment Approach (Sánchez, 2019) to
argue that the divergences heritage speakers show can be better accounted for in relation to crosslinguistic influence
at the level of bilingual alignments, linguistic proficiency and specific patterns of language exposure and usage.
Phonology and sentential semantics
Authors: Grimm Angela , Schulz Petra 
Published: December 2024

Abstract
The aim of this study is to investigate phonology (via consonant clusters) and sentential semantics (via exhaustivity in wh-questions) regarding their potential to characterize SLI in the context of bilingual acquisition. Using the German LITMUS-QU-NWR task and the exhaustivity task, the phonological and semantic abilities of 5- to 6-year-old simultaneous-bilingual (2L1) and early second language (eL2) learners of German with SLI were compared to their typically developing peers. The results suggest that in this age group language-dependent phonological knowledge regarding consonant clusters is a marker of SLI for 2L1 and eL2 children, while language independent knowledge of consonant clusters is a marker of SLI only for eL2 children. At age 5 to 6, exhaustivity is not a marker of SLI in either bilingual group. Consistent with the notion of subtypes of SLI, individual analyses revealed considerable heterogeneity within the two SLI groups. We argue that characterization of bilingual SLI requires analyses of group and individual data, and moreover, consideration of the age at testing in relation to timing in monolingual acquisition. The COST-tasks are suitable for combining both approaches.
Grounding analytical mechanics in statics: a didactic emphasis on the principle of virtual work
Authors: Weber Pereira Rodrigo , Karam Ricardo Avelar Sotomaior , Heidemann Leonardo Albuquerque , Veit Eliane Angela 
Published: December 2024

Abstract
Many textbooks on analytical mechanics introduce the Lagrangian formalism with D'Alembert's or Hamilton's principle. However, the validity of D'Alembert's principle is rooted in an ancient law of statics, the Principle of Virtual Work (PVW), which is rarely discussed in these texts, potentially causing difficulties. Likewise, the well-known tendency of nature to optimize physical phenomena is a straightforward consequence of the PVW, from which Hamilton's principle can also be derived. While Lagrange felt it necessary to dedicate half of his classical book to justify the validity of the PVW, today it is often regarded as a trivial intermediate step when establishing D'Alembert's principle. In this paper, following the path set by Lagrange—though in modern notation—the didactic potential of working with the PVW as an initial step before studying dynamics at the undergraduate level is explored. Beyond elucidating its conceptual richness and historical significance, several practical applications of the PVW are provided, aiming for a deeper understanding of the foundations of dynamics.
Enhanced giant magnetoresistance in Heusler alloy

(

Co
2

FeSi

/

Ag

)
N

multilayers for read sensor applications
Authors: Khamtawi R , Chureemart J , Chantrell R W , Chureemart P 
Published: December 2024

Abstract
We theoretically investigate the spin transport behavior of multilayer

[

Co

2

FeSi

/

Ag

]
N

structure for the application of next-generation read sensors in hard disk drive. To demonstrate the potential of the Heusler alloy-based current-perpendicular-to-plane giant magnetoresistance (CPP-GMR) device, we employ an atomistic model coupled with a spin accumulation model including the effect of a diffuse interface. The dynamics of magnetization is observed in the atomistic model and the calculation of magnetoresistance (MR) and MR ratio of the magnetic structure can be achieved by the spin accumulation model enabling us to investigate the spin transport behavior within the structure. The MR value can be directly calculated from the gradient of spin accumulation and spin current. The effect of injected current density is first investigated. It is found that increasing the current density results in a high MR ratio. Subsequently, to achieve a high performance reader, the number of coupled layers (N) is varied up to 16 to study its effect on the MR ratio. The calculated results indicate that increasing the number of layers N gives rise to the enhancement of the resistance change and MR ratio. At the critical point N = 5, further increasing N does not affect the MR ratio, which remains relatively unchanged. Interestingly, the MR ratio is doubled for

N
>
5

compared to N = 1. Our results demonstrate the possibility of enhancing the performance of multilayer CPP-GMR devices.
Study of the spatial measurement of electron density in the EAST discharge using a multichannel terahertz solid-source interferometer
Authors: Yan Huihui , Liu Haiqing , Wang Shouxin , Wei Xuechao , Yao Yuan , Zhang Yao , Peng Ximo , Lian Hui , Li Weiming , Jie Yinxian , Jiang Jun , Tian Yaoling 
Published: December 2024

Abstract
A vertical single-channel 0.65 THz solid-source interferometer (SSI) has been established at Experimental Advanced Superconducting Tokamak (EAST) for real-time electron density measurements and feedback. A line array detection scheme was proposed and successfully deployed on EAST to enhance the spatial resolution of the SSI system. The scheme utilizes an AlGaN/GaN line array high electron mobility transistor detector, and three channels of line-integrated electron density signals were measured. A representative density measurement was conducted with an intermediate frequency of 850 kHz in a discharge with a current (I
p) of 400 kA and electron cyclotron resonance heating power (P
ECRH) of 1.1 MW on EAST. Additionally, the detection of density perturbations by the SSI system during plasma discharges demonstrates its capability to study small-scale spatial magnetohydrodynamic phenomena. Further optical refinements and the development of advanced data processing algorithms are anticipated to enhance the measurement accuracy and overall performance of the line array detection scheme.