bluuebunny/crossref_metadata_2025_split huggingface dataset:
O ITINERÁRIO TERAPÊUTICO DE MULHERES TRANS AO ACESSO NO SERVIÇO DE SAÚDE
Authors: Guilherme Elias Coutinho , Gurgel Kamila Ribeiro , Silva Mabilla Paulina Ipuchima da , Leitão Mayra da Silva , Sousa Sara Fonseca de , Melo Willams Costa de , Oliveira Adriano dos Santos 
Published: December 2024

O itinerário terapêutico de pessoas transgênero no acesso aos serviços de saúde pode ser permeado por barreiras simbólicas, técnicas e organizacionais. Algumas das dificuldades enfrentadas são: Preconceito, Falta de informação, Despreparo dos profissionais de saúde, falhas no processo de referência e regulação, desarticulação com a Rede de Atenção Básica e a Rede de Atenção Psicossocial. Para a construção do itinerário terapêutico da população transgênero, foi importante ouvir como ocorrem os processos pela procura de saúde, os problemas e dificuldades encontrados e as experiências adquiridas no processo do cuidado, além de ouvir como foi ser tratado/a e como é se reconhecer como transgênero
GANTI RUGI KORBAN KECELAKAAN LALU LINTAS PERSPEKTIF HUKUM POSITIF DAN FIKIH MAZBAB ( STUDI KASUS POLRES BONE)
Authors: Laman Ilham 
Published: December 2024

Traffic accidents always cause losses, losses are a state of diminishment of a benefit possessed by a person, losses can be material or immaterial. From this background, three formulations of the problem are given birth, namely, how is the compensation for victims of traffic injury from a positive legal perspective.? secondly how is the compensation for victims of traffic accidents from the perspective of the Shafi'I school and its relevance in the Bone Police.? thirdly how is the settlement of compensation in the Bone Police? The research method uses field research with qualitative descriptive research methods. Descriptive research is a study that aims to describe the nature, facts and relationships between the phenomena studied. The purpose of qualitative descriptive research is to produce descriptive data in the form of images, words, of the observed behavior of the community. The researcher will immediately conduct interviews, observations for information. The results showed that, first in the Law. No.22 of 2009 concerning Road Traffic and Transportation, if a family peaceful road cannot be carried out then this matter is resolved in court. Secondly, compensation for victims of traffic accidents from the perspective of the shafi'I school and its relevance in the Bone Police, compensation is called diyat in islamic law and is obliged to pay and predominantly paid with camels at that time while its relevance in the Bone Police is the same as obliging to compensate for the negligence of the perpetrator even though the payment method is different from the perspective of the school because at that time the camel was the most privileged animal that could be given to the victim. Third, in the settlement of compensation in the police department, there were 426 cases of compensation for traffic accidents that occurred in 2021 where the settlement was peaceful or familial (not brought to justice) with material damages by interpreting the damages incurreds
RESEARCH ON OPTIMIZATION OF INDUSTRIAL BUILDING FACADES INTEGRATING WITH PHOTOVOLTAIC POWER
Authors: CHAI Hailong , ZENG Jingya 
Published: December 2024

Industrial buildings are important production carriers in urban space, but they also have problems such as high production energy consumption, serious environmental pollution, and poor built interface, which have attracted much attention. Building environment optimization and energy structure adjustment have become the focus of industrial building research. In the context of the national carbon neutral policy, this paper studies the impact of industrial buildings on the urban environment, combines photovoltaic power generation technology, explores the integrated design strategy of CdTe generation glass and industrial building facades, and uses the southwest cement plant project in Lijiang, Yunnan as an example, a practical study was carried out, aiming to use industrial building facade resources to improve the aesthetics and functionality of the building facade at the urban interface of the park. Research shows that the strong plasticity of CdTe photovoltaic glass can not only provide necessary power energy for industrial buildings and optimize the building's energy structure, but its color and material ductility can also improve the aesthetics of industrial building facades. This article provides certain reference and reference significance for subsequent related research.
Quality of life among patients with systemic lupus erythematosus in Karbala Governorate
Authors: Saad Rand 
Published: December 2024

Background: Systemic lupus erythematosus (SLE) is an autoimmune disease with a variety of clinical symptoms that primarily affect women of childbearing age causing a significant patient burden.
Objectives: To assess health-related quality of life (HRQOL) among patients with SLE and to evaluate its association with different sociodemographic and clinical characteristics of SLE patients.
Patients and methods: Seventy five patients with SLE who attended the rheumatology outpatient clinics of Imam Al-Hassan Al-Mujtaba Teaching Hospital, were enrolled in a cross-sectional study. Lupus quality of life (LupusQoL) was used to assess disease-specific health related quality of life; and SLE disease activity index (SLEDAI) was applied to evaluate disease activity.
Results: The mean age of the studied patients was 38.12±11.70 years and were 97.3% female. All LupusQoL domains were reduced. Intimate relationship accounted for the highest QoL score with a median of 50, and IQR of 25-100, whereas fatigue represented the lowest score with a median of 25, and IQR of 6.2-50. LupusQoL was positively correlated to address, education, disease duration, occupation, and impact on job especially in physical health domain with r equal (0.277, 0.342, 0.137, 0.240, 0.314respectively). LupusQol was negatively correlated with age (r= -0.461), and with disease activity (r= -0.292), with p- values of all were >0.05. Renal and neuropsychiatric involvement of the disease did not statistically correlate with HRQOL.
Conclusion: patients with SLE had low scores of all LupusQoL domains. There was significant positive correlation between LupusQoL domains and address, education, disease duration, occupation, and impact on job and significant negative correlation with age, and disease activity.
Key words: SLE, health related quality of life, LupusQoL
D-dimer and Long COVID19
Authors: Al-Shamma Sura 
Published: December 2024

D dimer is a soluble byproduct of fibrin degradation. It’s well known for its role in exclusion of VTE and other thromboembolic disorder. Recently with the emergence of COVID 19,D- dimer used as indicator of disease severity and outcome in acute phases. However there are limited data regarding significance of D dimer in long term COVID 19 .This literature review tried to elaborate the significance and mechanism of prolonged D dimer in long term COVID 19 .
Electrodiagnostic evaluation of autonomic dysfunction in patients with multiple sclerosis
Authors: Albaiaty Mays 
Published: December 2024

Abstract
Background: Autonomic dysfunction frequently affects multiple organs and systems in people with multiple sclerosis (PwMS), including the heart, bladder, and bowels, as well as sudomotor and sexual functions, and can have a significant negative impact on the quality of life.
Aim: to assess the effect of MS on autonomic nervous system (ANS) functions by electrodiagnostic measures and investigate the relationship of these measures with different demographic and clinical factors such as age, sex, duration of disease, type of treatment, the Expanded Disability Severity Scale (EDSS) score, and the Composite Autonomic Symptom Score-31 (COMPASS-31) score.
Methods: forty patients with a definite diagnosis of relapsing-remitting MS and 35 age- and sex-matched controls. The EDSS to assess disease severity and the COMPASS-31 questionnaire to test for degree of clinical autonomic disability, Ewing’s cardiovascular autonomic tests, and sympathetic skin response (SSR) as electrophysiologic tests for autonomic dysfunction were done.
Results: The heart rate during normal (HRNB), HR response to deep breathing (HRDB), and systolic blood pressure (BP) drop from supine to standing position were significantly different in the PwMS relative to the controls. Moreover, PwMS exhibited prolonged palmar SSR latency and reduced plantar SSR amplitude. Disease duration was negatively correlated with HRNB, HRDB, and heart rate during the Valsalva manoeuvre (HTVals). EDSS is also negatively correlated with HRNB and HRDB. Furthermore, COMPASS-31 also shows a negative correlation with HRDB. On the contrary, systolic PB drop and planter SSR amplitude were positively correlated with EDSS.
Conclusion: In MS, cardiac autonomic dysfunction affects both the parasympathetic and sympathetic NS. Alongside the cardiovascular system, the sympathetic sudomotor system is also impacted. The length and severity of the disease were correlated by parasympathetic abnormalities. No correlation was observed within the patient group between any autonomic function tests and age, sex, treatment type, or family history of MS.
Keywords: Multiple sclerosis, EDSS, autonomic function tests, COMPASS-31
La economía circular y las economías transformadoras. Alcances y tensiones en el País Vasco
Authors: Villalba-Eguiluz Unai 
Published: December 2024

Las economías transformadoras representan una heterogeneidad de enfoques y prácticas, muchas veces afines a la economía social y solidaria, que buscan emprender transiciones eco-sociales hacia otros modelos económicos alternativos. En el caso concreto de la economía circular, en la literatura existe controversia sobre su pertenencia, o no, al grupo de las economías transformadoras en función de los enfoques concretos que adopte. En este artículo contribuimos a delimitar y evaluar el alcance transformador de las diferentes propuestas (en base a criterios como el compromiso ecosocial, o el funcionamiento jerárquico/horizontal), e identificamos algunas de las tensiones que afrontan las economías transformadoras desde la práctica (como las surgidas por la interacción con instituciones públicas, el mantenimiento de viabilidad, o el escalamiento). Además, aportamos un estudio de caso desde el País Vasco, en el que contrastamos dos enfoques distintos: la visión sobre la economía circular propia de instituciones como IHOBE y Gobierno Vasco, orientada principalmente a la competitividad; y otro enfoque propio de las redes de economía social y solidaria, más bien orientado a la suficiencia. Concluimos que los enfoques orientados a la competitividad difícilmente podrían considerarse propios de las economías transformadoras; mientras que los enfoques orientados a la suficiencia sí, ya que suelen adoptar otros conceptos alternativos de circularidad social.
Identification and validation of apoptosis-related genes in acute myocardial infarction based on integrated bioinformatics methods
Authors: Zhu Haoyan , Li Mengyao , Wu Jiahe , Yan Liqiu , Xiong Wei , Hu Xiaorong , Lu Zhibing , Li Chenze , Cai Huanhuan 
Published: December 2024

Background
Acute myocardial infarction (AMI) is one of the most serious cardiovascular diseases. Apoptosis is a type of programmed cell death that causes DNA degradation and chromatin condensation. The role of apoptosis in AMI progression remains unclear.

Methods
Three AMI-related microarray datasets (GSE48060, GSE66360 and GSE97320) were obtained from the Gene Expression Omnibus database and combined for further analysis. Differential expression analysis and enrichment analysis were performed on the combined dataset to identify differentially expressed genes (DEGs). Apoptosis-related genes (ARGs) were screened through the intersection of genes associated with apoptosis in previous studies and DEGs. The expression pattern of ARGs was studied on the basis of their raw expression data. Three machine learning algorithms, Least Absolute Shrinkage and Selection Operator (LASSO), support vector machine-recursive feature elimination (SVM-RFE), and Random Forest (RF) were utilized to screen crucial genes in these ARGs. Immune infiltration was estimated by single sample gene set enrichment analysis (ssGSEA). Corresponding online databases were used to predict miRNAs, transcription factors (TFs) and therapeutic agents of crucial genes. A nomogram clinical prediction model of the crucial genes was constructed and evaluated. The Mendelian randomization analysis was employed to investigate whether there is a causal relationship between apoptosis and AMI. Finally, an AMI mouse model was established, and apoptosis in the hearts of AMI mice was assessed via TUNEL staining. qRT-PCR was employed to validate these crucial genes in the hearts of AMI mice. The external dataset GSE59867 was used for further validating the crucial genes.

Results
Fifteen ARGs (GADD45A, DDIT3, FEZ1, PMAIP1, IER3, IFNGR1, CDKN1A, GNA15, IL1B, EREG, BCL10, JUN, EGR3, GADD45B, and CD14) were identified. Six crucial genes (CDKN1A, BCL10, PMAIP1, IL1B, GNA15, and CD14) were screened from ARGs by machine learning. A total of 102 miRNAs, 13 TFs and 23 therapeutic drugs were predicted targeting these crucial genes. The clinical prediction model of the crucial genes has shown good predictive capability. The Mendelian randomization analysis demonstrated that apoptosis is a risk factor for AMI. Lastly, the expression of CDKN1A, CD14 and IL1B was verified in the AMI mouse model and external dataset.

Conclusions
In this study, ARGs were screened by machine learning algorithms, and verified by qRT-PCR in the AMI mouse model. Finally, we demonstrated that CDKN1A, CD14 and IL1B were the crucial genes involved in apoptosis in AMI. These genes may provide new target for the recognition and intervention of apoptosis in AMI.
Aluminiumsilikatfasern (Refractory Ceramic Fibres, RCF) [MAK value documentation in German language, 2019]
Authors: Hartwig A. ,   MAK Commission
Published: August 2019

Abstract
The German Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area has re‐evaluated aluminium silicate fibres considering all toxicological endpoints.
Aluminium silicate fibres cause mesotheliomas and lung tumours in rats and hamsters. In epidemiological studies, cancer risk was not associated with exposure to aluminium silicate fibres. Tumour formation in animals is a result of chronic inflammation; therefore, aluminum silicate fibres are a candidate for Carcinogen Category 4. However, the re‐evaluation showed that a maximum concentration at the workplace (MAK value) cannot be derived and aluminium silicate fibres thus remain classified in Carcinogen Category 2.
Aluminium silicate fibres are not taken up via the skin in toxicologically relevant amounts. There are no studies of sensitization.
Zirkoniumdioxid (alveolengängige Fraktion) [MAK value documentation in German language, 2019]
Authors: Hartwig A. ,   MAK Commission
Published: August 2019

Abstract

The German Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area has re‐evaluated zirconium dioxide [
1314‐23‐4
]. Zirconium dioxide is a biopersistent granular dust. Therefore, the respirable fraction of zirconium dioxide dust is classified in Carcinogen Category 4 and a maximum concentration at the workplace (MAK value) of 0.3 mg/m
3
× material density is established for the respirable fraction in analogy to the other biopersistent granular dusts. Additionally, this fraction is classified in Peak Limitation Category II with an excursion factor of 8. As zirconium dioxide is not systemically distributed and accumulates only locally in the lungs, no developmental toxicity is expected to occur at the MAK value of 0.3 mg/m
3
× material density (respirable fraction). Accordingly, zirconium dioxide is classified in Pregnancy Risk Group C. Zirconium dioxide is not a sensitizer and is not taken up via the skin in toxicologically relevant amounts.
Lindan [MAK value documentation in German language, 2019]
Authors: Hartwig A. ,   MAK Commission
Published: August 2019

AbstractThe German Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area has re‐evaluated the maximum concentration at the workplace (MAK value) of lindane [58‐89‐9] and its classification in category 4 for carcinogenic substances considering all toxicological endpoints. In several studies an increased risk of non‐Hodgkin lymphoma for lindane users in agriculture is described. After controlling for other pesticides, the risk decreased. Exposure or biomonitoring data are not available from these studies. From the viewpoint of the Commission, the studies are not sufficient to classify lindane as a human carcinogen. Because of its tumour‐promoting effects on the liver of the rat and the liver carcinogenicity in the mouse, lindane is still classified in category 4 for carcinogenic substances.The critical toxic effects of lindane are immunotoxic and immunomodulating effects. After inhalation exposure, NOAECs of 0.6 mg/m3(rat) and 1 mg/m3(mouse) can be derived for histological changes of the spleen, thymus and bone marrow and NOAELs of 0.45 mg/kg body weight for rats and 2 mg/kg body weight for mice for immunological effects. Excluding skin contact, exposure to the MAK value of 0.1 mg/m3for the inhalable fraction results in a daily intake of 0.014 mg/kg body weight (100 % absorption, 70 kg body weight and 10 m3respiratory volume) for humans. In this low concentration range, an inhibition of immunological responses is not likely and the MAK value is confirmed.Damage to the embryo or foetus is unlikely when the MAK value is not exceeded; therefore, the assignment to Pregnancy Risk Group C is confirmed as well.Skin contact may contribute significantly to systemic toxicity and the “H” notation is confirmed. Sensitization is not expected from the available data.
Ethanthiol [MAK value documentation in German language, 2019]
Authors: Hartwig A. ,   MAK Commission
Published: August 2019

Abstract

The German Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area has re‐evaluated the maximum concentration at the work place (MAK value) of ethanethiol [
75‐08‐1
]. No new studies are available for ethanethiol itself. Therefore, the MAK value is derived by read‐across with the structurally similar methyl mercaptan for which the MAK value of 0.5 ml/m
3
is based on slight behavioural changes at 2 ml/m
3
in a 90‐day inhalation study in rats. The MAK value of 0.5 ml/m
3
for ethanethiol is supported by a limited inhalation study with 3 volunteers, showing irritation and other symptoms after repeated exposure to ethanethiol in a concentration of 3.9 ml/m
3
, but not after 0.39 ml/m
3
. The behavioural changes in rats exposed to methyl mercaptan are presumably not neurotoxic effects but a result of the odour nuisance or the local irritation. Therefore, ethanethiol is classified in Peak Limitation Category I with an excursion factor of 1 by analogy with methyl mercaptan. There are no developmental toxicity studies and ethanethiol remains assigned to Pregnancy Risk Group D. According to skin absorption models, percutaneous absorption is expected to contribute significantly to systemic toxicity. Therefore, ethanethiol is designated with an “H”. There are no data on sensitization.
Paper‐Based Electrochromic Devices Enabled by Nanocellulose‐Coated Substrates
Authors: Lang Augustus W. , Österholm Anna M. , Reynolds John R. 
Published: August 2019

AbstractAs environmental considerations for both the processing and disposal of electronic devices become increasingly important, the ability to replace plastic and glass substrates with bioderived and biodegradable materials remains a major technological goal. Here, the use of cellulose nanofiber‐coated paper is explored as an environmentally benign substrate for preparing low‐resistance (460 Ω sq−1), colorless (a* = −2.3, b* = −2.7) printed poly(3,4‐ethylenedioxythiophene):poly(styrenesulfonate) (PEDOT:PSS) electrodes. The PEDOT:PSS/paper electrodes support the reversible oxidation of three electrochromic polymers (ECPs) (cyan, magenta, and yellow), affording the possibility for fully printed, color displays on paper. Lateral electrochromic devices (ECDs) incorporating an ion gel electrolyte are demonstrated where a magenta‐to‐colorless device achieves a color contrast (ΔE*) of 56 owing to a highly color‐neutral bleached state of the ECP (a* = −0.5, b* = 2.9). Black‐to‐colorless devices achieve ΔE* = 29 and are able to retain 86% of their color contrast after 9000 switches. The switching times of these lateral devices are quantified through colorimetric image analysis which shows comparable performance for devices constructed on paper as devices using ITO/glass electrodes (10 Ω sq−1). The paper ECDs are then combusted in air leaving 3% of the initial mass at 600 °C, highlighting this approach as a promising route toward disposable displays.
Solution‐Processable, High‐Performance Flexible Electroluminescent Devices Based on High‐k Nanodielectrics
Authors: Shanker Ravi , Cho Seungse , Choe Ayoung , Kim Minsoo P. , Khan Ziyauddin , Kang Saewon , Ko Hyunhyub 
Published: August 2019

AbstractFlexible alternating‐current electroluminescent (ACEL) devices have attracted considerable attention for their ability to produce uniform light emission under bent conditions and have enormous potential for applications in back lighting panels, decorative lighting in automobiles, and panel displays. Nevertheless, flexible ACEL devices generally require a high operating bias, which precludes their implementation in low power devices. Herein, solution‐processed La‐doped barium titanate (BTO:La) nanocuboids (≈150 nm) are presented as high dielectric constant (high‐k) nanodielectrics, which can enhance the dielectric constant of an ACEL device from 2.6 to 21 (at 1 kHz), enabling the fabrication of high‐performance flexible ACEL devices with a lower operating voltage as well as higher brightness (≈57.54 cd m−2 at 240 V, 1 kHz) than devices using undoped BTO nanodielectrics (≈14.3 cd m−2 at 240 V, 1 kHz). Furthermore, a uniform brightness across the whole panel surface of the flexible ACEL devices and excellent device reliability are achieved via the use of uniform networks of crossaligned silver nanowires as highly conductive and flexible electrodes. The results offer experimental validation of high‐brightness flexible ACELs using solution‐processed BTO:La nanodielectrics, which constitutes an important milestone toward the implementation of high‐k nanodielectrics in flexible displays.
Cancer‐Specific Therapy by Artificial Modulation of Intracellular Calcium Concentration
Authors: Wang Cheng , Yu Fangying , Liu Xuerong , Chen Shaoqing , Wu Rui , Zhao Rui , Hu Fuqiang , Yuan Hong 
Published: August 2019

AbstractCalcium (Ca2+) hemeostasis is crucial for the normal function of cellular biochemistry. The abnormal frequency of Ca2+ signaling in cancer cells makes them more vulnerable to Ca2+ modulation than normal cells. Here in this study, a novel cancer‐specific therapy by artificially triggering Ca2+ overload in cancer cells is proposed. The feasibility of this therapy is illustrated by successful coupling of selective extrusion (Ca2+) inhibition effect of Curcumin (Cur) and the effective Ca2+ generating capability of amorphous calcium carbonate (ACC) into a facilely prepared water responsive phospholipid (PL)–ACC hybrid platform (PL/ACC–Cur). The obtained results demonstrate that PL/ACC–Cur can specifically boost the intracellular Ca2+ concentration to cause Ca2+ overload and to trigger mitochondria‐related apoptosis in MCF‐7 cells while sparing normal hepatocyte (L02), which might be a promising approach for effective cancer therapy.