bluuebunny/crossref_metadata_2025_split huggingface dataset:
The role of irradiated heart and left ventricular volumes in heart failure occurrence after childhood cancer
Authors: Mansouri Imène , Allodji Rodrigue S. , Hill Catherine , El‐Fayech Chiraz , Pein François , Diallo Stéphanie , Schwartz Boris , Vu‐Bezin Giao , Veres Cristina , Souchard Vincent , Dumas Agnès , Bolle Stéphanie , Thomas‐Teinturier Cécile , Pacquement Hélène , Munzer Martine , Bondiau Pierre‐Yves , Berchery Delphine , Fresneau Brice , Oberlin Odile , Diallo Ibrahima , De Vathaire Florent , Haddy Nadia 
Published: December 2018

BackgroundPaediatric cancer survivors have a high risk of developing cardiac diseases, and the most frequent cardiac disease is heart failure (HF). The radiation dose–volume effects in the heart and cardiac substructures have not been explored in childhood cancer survivors (CCS). Therefore, the role of irradiated heart volume in the occurrence of HF among this population remains unclear. The aims of this study were to determine the doses and irradiated volumes of the heart and left ventricle (LV) related to the risk of HF in CCS and to investigate the impact of anthracycline exposure on this risk.Methods and resultsA case‐control study nested in the French Childhood Cancer Survivors Study cohort. The mean heart and left ventricular doses and volumes indicators were estimated by reconstruction of individual treatments. A total of 239 HF cases and 1042 matched controls were included. The median age of HF diagnosis was 25.1 years. The median volume of the heart that received ≥ 30 Gy was 61.1% for cases and 16.9% for controls. In patients who did not receive anthracycline, the risk of HF was increased 3.6‐fold when less than 10% of the LV received ≥ 30 Gy when compared to patients who were not exposed to any cardiac radiation and anthracycline.ConclusionsSmall irradiated volumes of the heart or LV were significantly associated with HF risk. To the author's knowledge, this is the first study to report a dose–response relationship based on dose–volume indicators in CCS, which can be translated efficiently into current clinical practice.
The effect of total intravenous anaesthesia with propofol on postoperative pain after third molar surgery: A double‐blind randomized controlled trial
Authors: Wong Stanley Sau Ching , Leung Mike Yiu Yan , Cheung Chi Wai 
Published: December 2018

AbstractBackgroundTotal intravenous anaesthesia (TIVA) with propofol may reduce pain after surgery compared with inhalational anaesthetic techniques. Whether propofol provides analgesic benefit may be influenced by the surgical procedure and anaesthetic/analgesic regime. Third molar surgery is a consistent and fairly standard surgical technique that provides a good model for postoperative pain. We investigated whether propofol TIVA or sevoflurane (SEVO) inhalational anaesthesia would produce better quality pain relief after third molar surgery.MethodsIn this double‐blind, randomized controlled trial, patients scheduled for bilateral third molar surgery received propofol TIVA or SEVO inhalational anaesthesia. Postoperative numerical rating pain scores, analgesic consumption, adverse effects and global pain satisfaction were assessed.ResultsData from 48 patients in each group were analysed. The area under curves for numerical rating scale pain scores were significantly lower in the propofol TIVA group at rest and during mouth opening between 1 and 72 hr after surgery (p = 0.013 at rest, p = 0.021 with mouth opening). There was no difference in postoperative analgesic consumption. Propofol TIVA was associated with less postoperative headache (p = 0.041 in the postoperative anaesthetic care unit, p = 0.036 in ward). There were no differences in other adverse effects including postoperative nausea and vomiting. Global pain satisfaction and level of postoperative discomfort at 24 hr after surgery were significantly better in the propofol TIVA group (p = 0.008 and p = 0.009, respectively).ConclusionPropofol TIVA was associated with reduced postoperative pain after bilateral third molar surgery, but did not reduce postoperative analgesic consumption.SignificanceChoice of general anaesthetic technique can affect postoperative analgesia. The results of this study suggest that propofol TIVA improves postoperative pain and patient satisfaction after third molar surgery compared to inhalational anaesthesia.
Rational Synthesis of Hierarchical Bramble‐Shaped Co/CoO Nanofibers with Enhanced Lithium Storage Properties
Authors: Liu Hao , Li Dong , Ji Xueyang , Lu Qifang 
Published: December 2018

AbstractThe hierarchical bramble‐shaped Co/CoO nanofibers have been successfully synthesized by rational and delicate electrospinning/post‐thermal treatment. The metal Co thorns are distributed homogeneously on the surface of CoO nanofiber matrix. The hierarchical Co/CoO nanofibers manifest the remarkable lithium storage performance with excellent rechargeable stability (charge/discharge capacity of 794.2/794.4 mAh g−1 after 200 cycles) and improved rate capacities (discharge capacity of 285.4 mAh g−1 at the high rate of 10 C, 1 C=716 mA g−1), which could be attributed to the advantage of unique hierarchical structures to keep the structural stability and hold the large specific surface area (153.62 m2 g−1) providing the favorable electronic and lithium ion transport by increasing the contact area with the electrolyte, as well as the presence of metal Co thorns. The present study offers a strategy for the rational synthesis of promising anodes with hierarchical structures for superior lithium storage.
Seismic protection of rocking structures with inerters
Authors: Thiers‐Moggia Rodrigo , Málaga‐Chuquitaype Christian 
Published: December 2018

SummaryThe seismic behaviour of a wide variety of structures can be characterized by the rocking response of rigid blocks. Nevertheless, suitable seismic control strategies are presently limited and consist mostly on preventing rocking motion all together, which may induce undesirable stress concentrations and lead to impractical interventions. In this paper, we investigate the potential advantages of using supplemental rotational inertia to mitigate the effects of earthquakes on rocking structures. The newly proposed strategy employs inerters, which are mechanical devices that develop resisting forces proportional to the relative acceleration between their terminals and can be combined with a clutch to ensure their rotational inertia is only employed to oppose the motion. We demonstrate that the inclusion of the inerter effectively reduces the frequency parameter of the block, resulting in lower rotation seismic demands and enhanced stability due to the well‐known size effects of the rocking behaviour. The effects of the inerter and inerter‐clutch devices on the response scaling and similarity are also studied. An examination of their overturning fragility functions reveals that inerter‐equipped structures experience reduced probabilities of overturning in comparison with uncontrolled bodies, while the addition of a clutch further improves their seismic stability. The concept advanced in this paper is particularly attractive for the protection of rocking bodies as it opens the possibility of nonlocally modifying the dynamic response of rocking structures without altering their geometry.
Carer insights into self‐harm in the very old: A qualitative study
Authors: Wand Anne Pamela Frances , Peisah Carmelle , Draper Brian , Brodaty Henry 
Published: December 2018

ObjectiveTo examine the insights of carers to better understand self‐harm in their older relatives.MethodsAn in‐depth interview was conducted with the nominated relative/friend (carer) of a person over 80 who had self‐harmed within the last month. Carer interpretation and experience of the self‐harm and clinical care were explored qualitatively. Audio recordings were transcribed and the content thematically analyzed using N‐VIVO.ResultsThirty‐two carers of 30 older people who self‐harmed were interviewed. Physical, social, and psychological issues were identified as contributory to self‐harm. Themes relating to the perceived barriers to seeking help included “they can't communicate,” “suicide and secrets,” and “invalidation.” Themes for the intent of self‐harm were “attention seeking” and “wanting to die.” Themes which emerged for consequences of self‐harm for carers were “anger,” “guilt and self‐blame,” and “it made us ill.” Themes for solutions to address the underlying factors leading to self‐harm were “more practical support and structure,” “improving communication,” “removing means of self‐harm,” “advance care directives as a solution for suffering,” and “ignoring self‐harm.” Clinical care themes were “shared shame and stigma,” “safety and supervision vs being locked up,” “clinicians dismissing the carer,” and “relief and support.”ConclusionsValidation of carer perspectives and understanding family dynamics may improve communication at various system levels and inform interventions for older persons, concurrently support families, and potentially reduce risk of repeat self‐harm. Good care must be holistic, be person‐centred, and relieve carer burden. A shared understanding and psychotherapeutic approaches to management of self‐harm in late life should be considered.
Probability prediction of peak break‐up water level through vine copulas
Authors: Yu Kun‐xia , Zhang Xiang , Li Peng , Li Zhanbin , Qin Yi , Sun Qian 
Published: December 2018

AbstractPrediction of the peak break‐up water level, which is the maximum instantaneous stage during ice break‐up, is desirable to allow effective ice flood mitigation, but traditional hydrologic flood routing techniques are not efficient in addressing the large uncertainties caused by numerous factors driving the peak break‐up water level. This research provides a probability prediction framework based on vine copulas. The predictor variables of the peak break‐up water level are first chosen, the pair copula structure is then constructed by using vine copulas, the conditional density distribution function is derived to perform a probability prediction, and the peak break‐up water level value can then be estimated from the conditional density distribution function given the conditional probability and fixed values of the predictor variables. This approach is exemplified using data from 1957 to 2005 for the Toudaoguai and Sanhuhekou stations, which are located in the Inner Mongolia Reach of the Yellow River, and the calibration and validation periods are divided at 1986. The mean curve of the peak break‐up water level estimated from the conditional distribution function can capture the tendency of the observed series at both the Toudaoguai and Sanhuhekou stations, and more than 90% of the observed values fall within the 90% prediction uncertainty bands, which are approximately twice the standard deviation of the observed series. The probability prediction results for the validation period are consistent with those for the calibration period when the nonstationarity of the marginal distributions for the Sanhuhekou station are considered. Compared with multiple linear regression results, the uncertainty bands from the conditional distribution function are much narrower; moreover, the conditional distribution function is more capable of addressing the nonstationarity of predictor variables, and the conclusions are confirmed by jackknife analysis. Scenario predictions for cases in which the peak break‐up water level is likely to be higher than the bankfull water level can also be conducted based on the conditional distribution function, with good performance for the two stations.
Coordination Assembly of the Water‐Soluble Ti4(embonate)6 Cages with Mn2+ Ions
Authors: He Yan‐Ping , Yuan Lv‐Bing , Chen Guang‐Hui , Zhang Lei , Zhang Jian 
Published: December 2018

AbstractIn the past decades, great efforts have been devoted to the design and self‐assembly of discrete metal‐organic cages (MOCs). The further assembly of cages into advanced supramolecular materials is relatively less developed. Previously, we reported a water‐soluble Ti4L6 cage (L=embonate), which has been applied as the starting material to realize coordination assembly with different metal ions through two‐step reaction. In this work, by employing the Ti4L6 cages to assemble with Mn2+ ions in the presence of piperazine and melamine, a Ti4L6−Mn2 cage and a Z‐shaped Ti4L6−Mn2 chain structure have been synthesized and structurally characterized, respectively.
Successful treatment with sorafenib for sunitinib‐refractory metastatic papillary renal cell carcinoma: Potential impact of Raf overexpression on predicting the efficacy of sorafenib
Authors: Morinaga Ryota , Kawahara Takashi , Teranishi Jun‐ichi , Chuma Makoto , Izumi Koji , Miyoshi Yasuhide , Yao Masahiro , Otani Masako , Miyamoto Hiroshi , Uemura Hiroji 
Published: December 2018

IntroductionThe prognosis of type 2 papillary renal cell carcinoma is often poor. We herein report a case of papillary renal cell carcinoma with liver metastasis that was successfully treated with sorafenib as a second‐line therapy.Case presentationAn 82‐year‐old man who had undergone radical nephrectomy 5 years previously experienced biopsy‐proven liver metastasis. He received sunitinib as a first‐line treatment; the dose was initially 12.5 mg/day and was escalated to 25 mg/day, but it was discontinued due to several adverse events. We then switched to sorafenib as a second‐line treatment, which resulted in a partial response (51% reduction in tumor size); the patient showed no recurrence 5 months after the initiation of sorafenib treatment. An immunohistochemical analysis revealed the overexpression of Raf in both the primary and metastatic tumors.ConclusionAs sorafenib blocks Raf signaling, the expression of Raf may serve as a useful predictor of the efficacy of sorafenib.
LINC00969 promotes the degeneration of intervertebral disk by sponging miR‐335‐3p and regulating NLRP3 inflammasome activation
Authors: Yu Lei , Hao Yingjie , Xu Chaojun , Zhu Guangduo , Cai Yingchun 
Published: December 2018

AbstractLong noncoding RNAs (LncRNAs) may serve as miRNA sponges to regulate the expressions of miRNA target genes. LncRNA LINC00969 has been indicated to be upregulated in intervertebral disk degeneration. However, the regulatory mechanism of LINC00969 in intervertebral disk degeneration progression remains unclear. Differently expressed LINC00969, miR‐335‐3p, and thioredoxin‐interacting protein (TXNIP) were determined in nucleus pulposus (NP) tissues and cells isolated from patients with intervertebral disk degeneration. The interaction between LINC00969, miR‐335‐3p, and TXNIP was also assessed. In this study, we demonstrated that LINC00969 was highly expressed, whereas miR‐335‐3p was aberrantly downregulated in NP tissues and cells of intervertebral disk degeneration patients. In addition, our results suggested that LINC00969 enhanced NP cell apoptosis. More importantly, LINC00969 was identified to function as a competitive endogenous RNA (ceRNA) for miR‐335‐3p to positively regulate TXNIP expression in vitro. Our study provided evidence for the cross‐talk between LINC00969, miR‐335‐3p, and TXNIP, shedding light on the therapy for intervertebral disk degeneration. © 2018 IUBMB Life, 71(5):611–618, 2019
Role of vitamin E in nonalcoholic fatty liver disease
Authors: Nagashimada Mayumi , Ota Tsuguhito 
Published: December 2018

AbstractNonalcoholic fatty liver disease (NAFLD) is one of the most common chronic liver diseases worldwide. NAFLD manifests as hepatic lipid accumulation, insulin resistance, and inflammation, and can progress to nonalcoholic steatohepatitis (NASH) and cirrhosis. However, the underlying mechanisms of NAFLD, including those that drive its progression, are unclear. Both liver‐resident (Kupffer cells) and recruited macrophages play a crucial role in the development of insulin resistance and NASH. Therefore, NALFD could potentially be ameliorated by modifying the polarization of macrophages/Kupffer cells. Reactive oxygen species induce oxidative stress, which is implicated in the progression of NASH. Micronutrients, including vitamins, are potent antioxidants that exert anti‐inflammatory effects, and are used in the treatment of NAFLD. We review here the molecular mechanisms of the pathogenesis of NAFLD and the potential utility of vitamin E in its prevention and/or treatment. © 2018 IUBMB Life, 71(4):516–522, 2019
Combination of D‐dimer and carcinoembryonic antigen levels as a predictive and prognostic biomarker in advanced colorectal cancer patients
Authors: Li Huiping , Zhao Shuangshuang , Jing Zhao , Li Juan , Shuanying Yang , Zhang Ni 
Published: December 2018

AbstractIn view of the controversial findings on the utility of D‐dimer and carcinoembryonic antigen (CEA) as biomarkers in advanced colorectal cancer (CRC), we evaluated the predictive and prognostic value of the D‐dimer and CEA levels in unresectable advanced CRC patients treated with first‐line chemotherapy. A total of 57 previously untreated patients with advanced CRC were enrolled. We assessed both plasma D‐dimer and CEA levels at the start (D1 and CEA1) and after two cycles (D2 and CEA2) of chemotherapy. Based on the respective optimal cut‐off values of 0.8 and 5.0 ng/mL for D1 and CEA1, respectively, patients were divided into low and high D‐dimer or CEA groups. The results show that D1 and CEA1 levels were correlated (r = 0.392, P = 0.003). Mean CEA2 was reduced by 26.24 ng/mL in patients with partial response and stable disease and increased by 165.95 ng/mL in patients with progressive disease relative to the CEA1 level (P < 0.001). However, no correlation was evident between changes in the D‐dimer levels and chemotherapy response (P = 0.441). The overall survival (OS) of patients with high D1 was shorter than that of patients with low D1 (median OS, 16 vs 29 months, P = 0.009). Multivariate analyses further demonstrated that D1 (P = 0.042) and chemotherapy response (P = 0.016), but not CEA, were independent prognostic factors for OS in advanced CRC. Taken together, our result found that changes in CEA levels may serve as a predictive biomarker of the chemotherapy response and baseline D‐dimer levels as a prognostic biomarker of OS in patients with advanced CRC.
Distance supervision in the Aiglé Foundation's Latin American Psychotherapy Training Program
Authors: Fernández Álvarez Héctor , del Pilar Grazioso Maria , Kirszman Diana 
Published: December 2018

AbstractLatin American literature on clinical supervision is limited and literature concerning technology‐assisted supervision is virtually nonexistent. We address this gap, providing our perspective on the use of technology in distance supervision within Argentina and Guatemala. Despite important differences, these two countries share many sociocultural features. We contextualize these perspectives, describing therapist training according to the Integrative Model of Fundación Aiglé. Through the use of vignettes, we illustrate contextualized training experiences, concluding with a synthesis of strengths and weaknesses encountered when implementing the use of technology in distance supervision.
Histomicroscopy and normal anatomy of the adult killifishAphanius hormuzensis(Teleostei; Aphaniidae) from the Persian Gulf coastal environment
Authors: Motamedi Mina , Shamsaldini Fatemeh , Teimori Azad , Hesni Majid Askari 
Published: December 2018

AbstractThe histomicroscopy and normal anatomy of the major body organ systems were investigated in the adult killifish,Aphanius hormuzensisusing histological examination, X‐ray imaging, double staining, light microscopy and scanning electron microscopy (SEM). Based on the histomicroscopic observations, the kidney, liver and swim bladder in the studied species were comparable to other fish models. The anterior portion of the kidney is bulbous, while the posterior portion is narrow and elongated; the liver has a single lobe and the swim bladder is a single‐chambered organ with no connection to the digestive tract (physoclistous). X‐ray imaging and double staining examination showed 12 abdominal and 15 caudal vertebrae and a single hypural plate in the caudal skeleton. According to light microscopy, the scales were rounded to pentagonal in shape with three types of radii (primary, secondary and tertiary), and the urohyal bone was elongated. SEM microscopy showed a single row of tricuspid teeth on the upper and lower jaw, respectively, each tooth has two lateral cusps that are shorter than the middle one. The number of teeth was 17–18 in the upper jaw and 19–20 in the lower jaw. The saccular otoliths were rounded‐trapezoid in shape with a moderately incised and V‐shaped excisura. The members of killifishes are an important group for biologists because of their evolutionary properties, regeneration capacity and usefulness as biological control and also for the ecotoxicological assessment of environmental pollution. The outcomes of this study may provide a useful basis for future research on the genusAphanius.
Outcome of radiological interventions in pediatric gastrointestinal diseases: A large tertiary center experience
Authors: Nabi Zaheer , Singh Jagadeesh R , Haris Arafat , Shava Upender , Chavan Radhika , Nageshwar Reddy Duvvur 
Published: December 2018

BackgroundInterventional radiology (IR) is an indispensable component of multidisciplinary care in various gastrointestinal (GI) diseases. The literature on safety and utility of IR is limited in children.ObjectivesIn this study, we aim to analyze the outcomes of IR in various pediatric GI diseases.MethodsThe data of children (≤18 years) who underwent radiological interventions for GI disorders (2009–2017) were analyzed, retrospectively. The indications for interventions included vascular (Budd Chiari syndrome [BCS], pseudoaneurysm) and nonvascular (pancreatic fluid collections [PFCs], cholangitis and anastomotic biliary strictures). The outcomes of radiological interventions, including success and adverse events, were assessed.ResultsA total of 93 children (mean age 13.45 ± 4.09 years) underwent radiological interventions for vascular (chronic BCS = 14, pseudoaneurysm = 28) or nonvascular (PFCs = 33, hepaticojejunostomy strictures or leaks = 12, cholangitis = 6) indications. Of 33 children who underwent drainage of PFCs, clinical success was noticed in 32 children during a mean follow‐up of 32.4 ± 21.66 months; 11 children with persistent external pancreatic fistula were managed with endoscopic pancreatic ductal stenting (8 children) and internalization of transgastric drain (3 children). In children who underwent hepatic vein or inferior vena cava stenting for BCS, mean stent patency was 78.57% during a follow‐up of 24.1 ± 13.78 months. In children with pseudoaneurysms, angioembolization was successfully performed in 92.8% patients. Re‐bleeding was noticed in two children, one of whom required reintervention. In children who underwent percutaneous transhepatic biliary drainage, resolution of anastomotic strictures was noticed in all during a follow‐up of 36.1 ± 13.73 months.ConclusionInterventional radiology is safe and effective in the management of various pediatric GI diseases.