bluuebunny/crossref_metadata_2025_split huggingface dataset:
ДОСЛІДЖЕННЯ ПЕРСПЕКТИВ МОДЕЛІ СТАКЕЛЬБЕРГА ТЕОРІЇ ІГОР У ХОЛІСТИЧНІЙ МЕДИЦИНІ
Authors: БАРИШИЧ ЛУКА 
Published: December 2024

The article presents an analysis of the use of the Stackelberg model for modeling and analyzing leadership-evolutionary population systems in medicine. The current trends in the use of game theory in the management of patients during chemotherapy are analyzed. The concept of holistic medicine and the possibilities of further integration and development of the Stackelberg model are outlined.
The intersection of game theory and medicine has become a promising avenue for understanding and managing complex systems, particularly in the context of chemotherapy and patient care. This paper explores the analysis of leadership-evolutionary population systems in medicine using the Stackelberg model. It delves into current trends in the application of game theory within patient management during chemotherapy, shedding light on the potential of holistic medicine and the integration of the Stackelberg model for further advancements in this field.
The Stackelberg model, a cornerstone in game theory, has proven valuable in modeling and analyzing leadership dynamics within evolving population systems. In the medical context, its application offers insights into strategic interactions among stakeholders, influencing the trajectory of patient care during chemotherapy. The paper examines the intricacies of the Stackelberg model, emphasizing its role in understanding decision-making processes and optimizing resource allocation in healthcare settings.
Further improvement of approaches to the use of game theory models in the analysis, simulation and management of processes in medicine requires the adoption of an arsenal of concepts and tools from the holistic theory of medicine. Current models, including those by Stackelberg, have limited capabilities to assess the evolutionary system's resistance to the actions of an external agent.
An in-depth analysis of current trends reveals a growing reliance on game theory for patient management during chemotherapy. Game-theoretic approaches enable healthcare professionals to anticipate and respond to evolving situations, fostering more effective and adaptive strategies. This section explores real-world examples and success stories where game theory has played a pivotal role in optimizing treatment plans and improving patient outcomes.
Despite the advancements made through the integration of the Stackelberg model and holistic medicine, challenges persist. This paper addresses limitations in current models, emphasizing the need for a broader conceptual framework to evaluate evolutionary systems' resilience to external influences. It calls for continued research and innovation in incorporating holistic principles into game theory models, envisioning a future where healthcare management is characterized by a more nuanced and adaptive approach.
ВИКОРИСТАННЯ ДІДЖИТАЛ-ТЕХНОЛОГІЙ В РОБОТІ КУРАТОРА АКАДЕМІЧНОЇ ГРУПИ ЗАКЛАДІВ ВИЩОЇ ОСВІТИ
Authors: СКІДАН ВЛАДИСЛАВА , ВОЛІВАЧ АНТОНІНА , НІКОНОВ ОЛЕГ , МИТЕЛЬСЬКА ОЛЕНА 
Published: December 2024

The rapid development of modern digital technologies and the development of mobile applications, with their subsequent implementation, enhance communication skills and the solution of complex tasks in society, especially in organizing the educational activities of higher education institutions
Therefore, the use of digital technologies in the work of academic group curator represents an important and relevant direction in modern education. Here are several key aspects that highlight the importance of this initiative:
Convenience and accessibility: The mobile application allows curators to easily access necessary information and tools through their smartphones. This provides instant access to important data and simplifies the workflow.
Effective management: The application provides curators with tools for effectively tracking students academic progress. They can quickly analyze data and make management decisions based on objective information.
Improved communication: Digital technologies streamline communication among curators, students, and parents. Through chats, messaging, and email, curators can easily communicate and share information.
Workflow optimization: The application contributes to optimizing the workflow of curators. They can quickly find the necessary information, complete tasks, and increase the efficiency of their work.
Improvement of the educational process: By tracking students progress, curators can provide individual support and recommendations to enhance academic achievements.
Interactions with parents: The application allows curators to engage parents in the educational process by sending them reports and information about their children performance.
Analysis and planning: Data analysis tools in digital technologies help curators make informed decisions and plan future activities.
The use of digital technologies in the work of an academic group curator improves management and the educational process, as well as enhances communication and work efficiency.
ДОСЛІДЖЕННЯ ВПЛИВУ ЧАСТОТНИХ ВЛАСТИВОСТЕЙ СЛУХУ В ПРОЦЕСІ ВИМІРЮВАННЯ ГУЧНОСТІ ЗВУЧАННЯ АУДІОКОНТЕНТУ
Authors: КОЛЬЦОВА ОЛЕКСАНДРА , ХІВРЕНКО РУСЛАН , ГРАЧОВ АРТУР 
Published: December 2024

Nowadays the problem of correct estimation and measurement of TV- and sound broadcasting programmes loudness is of great importance. The European Broadcasting Union (EBU) has established a special investigation group, dealing with loudness estimation and normalization, similarly, ITU emphasizes on the importance of objective measurement of audio program loudness to facilitate program delivery and exchange, and to provide more comfortable listening experience for audiences. In Recommendation ITU-R BS.1770-5 the modern algorithm of objective loudness measurement is described in detail. This algorithm includes frequency weighting of the measured audio signal to assume frequency properties of human auditory system, but such weighting concerns only the lower part of sound frequency band. In this article, the authors raise the question of the necessity of taking into account the dependence of sensitivity of the human auditory system on upper frequencies of the sound band. A brief overview of the existing representations of the frequency response of hearing sensitivity when listening to different types of sound signals is provided. Also in the article are discussed the results of subjective assessment of appreciability of changes in loudness of audio content of different types (speech and music) while changing the audio signal’s level on the upper frequencies of sound band. In one case the level of audio signal was adjusted according to the equal loudness contour corresponding to 60 phones of loudness level, and in another case, according to one of the variants of the averaged psophometric curve. The results of subjective assessment for these two cases were compared with each other.
For all processed sound fragments, a confidence intervals were calculated based on the indicator of appreciability of changes in loudness, percieved by the listeners, and evaluated the accuracy of the results.
Based on the results obtained from subjective assessment, further ways of conducting of the research are proposed.
The prevalence and risk factors of apathy among the Canadian long-term care residents with Alzheimer's disease and related dementias
Authors: Agboji Aderonke , Freeman Shannon , Banner Davina , Armstrong Joshua , Martin-Khan Melinda 
Published: December 2024

Background Apathy is a prevalent and debilitating neuropsychiatric symptom among persons living with Alzheimer's disease and related dementias, particularly those residing in long-term care facilities (LTCF). Despite its profound effects on the quality of life for both residents and their caregivers, apathy remains underrecognized and poorly understood in the context of dementia care. Objective To investigate the prevalence and biopsychosocial characteristics of apathy among newly admitted residents with dementia in Canadian LTCF using an Apathy Index derived from the interRAI Minimum Data Set (MDS) 2.0. Methods This cross-sectional study analyzed data from newly admitted residents with dementia from various LTCF (N = 97,789) across seven Canadian provinces between 2015 and 2019. Logistic regression analysis was performed to determine the relationship between apathy and multiple variables including sociodemographic and clinical variables. The biopsychosocial model of health was used to guide analysis. Results The prevalence rate of apathy among the Canadian long-term care residents with Alzheimer's disease and related dementias was 13.1%. Apathy was associated with various variables including male sex, pain, use of psychotropics, high Activity of Daily Living Self-Performance Hierarchy Scale scores, depression, aggression, severe cognitive impairment, and insomnia. Preferences for certain activities such as card games, art and craft, reading, music and exercise were inversely related to apathy while gardening was not. Conclusions By shedding light on this complex phenomenon within a Canadian context, we recommend that targeted interventions and improved care strategies to enhance the well-being of persons living with dementia should be prioritized in LTCF.
Autonomy, Freedom & Mobility
Authors: Shekaran Nidhi , Liao Ashley , Soldatić Karen 
Published: December 2024

<p>This book was created as part of the ADDEPT - Autonomy, Diversity & Disability: Everyday Practices of Technology funded by ARC Linkage Project LP190100099. The digital narratives were co-created with participants across a set of online and face-to-face workshops in addition to focus groups and follow-up one-to-one interviews. Each of the participants worked with the project team to examine, explore and create these digital accessible books of their personal experiences with everyday technologies to share the impact of such technologies upon their daily lives. Over a period of two years, research participants were able to critically engage with AI technologies and create these books to publicly disseminate their diverse experiences with the aim of enabling others to learn from their personal experiences. The stories are developed from the narratives of the participants, using AI technologies such as Mid Journey to generate illustrations and Chat GPT to develop the alternative text that describes the illustrations. Accessibility information: For the alternative text, text to voice, EPUB version and copies translated to other languages (Arabic, Chinese Traditional, Chinese Simplified and Vietnamese). Please visit <a href="https://www.westernsydney.edu.au/ics/projects/autonomy,_diversity_and_disability_everyday_practices_of_technology" target="_blank">https://www.westernsydney.edu.au/ics/projects/autonomy,_diversity_and_disability_everyday_practices_of_technology</a> </p>
Introducing Disability and the Global South (DGS): we are critical, we are open access!
Authors: Grech Shaun , Soldatić Karen 
Published: December 2024

<p>We are delighted to present the very first issue of <em>Disability and the Global South</em> (DGS). We have been working hard to finalise this issue with much enthusiasm. The idea of DGS goes back a couple of years and responds to a number of concerns as we engaged in the area as academics, activists, and practitioners. These concerns remain as we write, reconfirming the timely importance of this journal. </p>
Pemetaan Klasifikasi dan Analisis Perubahan Vegetasi Mangrove di Pantai Indah Kapuk Tahun 2013 dan 2023
Authors: Putri Nabila Randrika , Firmansyah Rully , Agustin Laila Fakarisma , Kurniawan Robert 
Published: December 2024

Mangrove merupakan sekumpulan dari pohon kecil yang tumbuh subur di zona pasang surut delta sungai, laguna, muara, dan sistem pesisir. Menurut Kementrian Lingkungan Hidup dan Kehutanan, telah terjadi deforestasi dengan luas 12.647 hektar per tahun. Isu lingkungan ini mengancam seluruh vegetasi mangrove di seluruh Indonesia, tak terkecuali di kawasan Pantai Indah Kapuk (PIK) yang berada di Kota Jakarta Utara dan Kabupaten Tangerang. Akibat pembangunan dan aktivitas manusia secara masif, lahan mangrove di kawasan PIK terindikasi mengalami penurunan selama satu dekade terakhir. Tujuan dari penelitian ini adalah untuk mengamati perubahan luas hutan mangrove yang ada di kawasan Pantai Indah Kapuk pada tahun 2013 dan 2023. Metode yang digunakan dalam penelitian ini adalah Classified and Regression Tree (CART) dengan menggunakan citra Landsat 8. Akurasi yang digunakan untuk penilaian akurasi adalah akurasi keseluruhan. Dari hasil klasifikasi, didapatkan hasil bahwa luas lahan mangrove tahun 2013 sebesar 16,612 km2 kemudian berkurang menjadi 14,532 km2. Hal ini disebabkan karena adanya perubahan alih fungsi lahan mangrove.
Implementasi SEM-PLS pada Analisis Pengaruh Tujuan Pembangunan Berkelanjutan terhadap Indeks Kebahagiaan Indonesia
Authors: Gunawan Ade Putri , Rozi Fachrur 
Published: December 2024

Pada tahun 2021 angka indeks kebahagiaan Indonesia meningkat dari 70,69 menjadi 71,49. Badan Perserikatan Bangsa-Bangsa menjadikan Tujuan Pembangunan Berkelanjutan (TPB) sebagai komitmen global untuk meningkatkan kesejahteraan dan kebahagiaan masyarakat. Penelitian ini bertujuan untuk mengetahui pengaruh TPB terhadap indeks kebahagiaan Indonesia tahun 2021 menggunakan analisis Structural Equation Modeling-Partial Least Square (SEM-PLS) dan sebagai masukan bagi pembuat kebijakan khususnya pemerintah dalam meningkatkan kesejahteraan untuk mendukung pelaksanaan TPB. Penelitian ini menganalisis 19 indikator yang dikelompokkan dalam 3 variabel dan 12 variabel dengan 40 indikator. Data dalam penelitian ini diperoleh dari website Badan Pusat Statistik. Analisis SEM-PLS dilakukan dengan membuat spesifikasi model pengukuran dan struktural, mengevalusi model pengukuran serta model struktural, dan menguji kebaikan model SEM-PLS. Ditemukan bahwa variabel tanpa kelaparan (0,708), variabel air bersih dan sanitasi layak (0,506) serta variabel keadilan dan kelembagaan yang tangguh (0,580) berpengaruh positif terhadap dimensi perasaan, sedangkan variabel tanpa kemiskinan (-0,541) berpengaruh negatif terhadap dimensi perasaan. Hasil uji bootstraping dalam penelitian ini digunakan untuk mengevaluasi tingkat signifikansi dari koefisien model jalur. Variabel tanpa kelaparan (0,988) serta variabel air bersih sanitasi layak (0,347) berpengaruh positif terhadap dimensi makna hidup, sedangkan variabel kehidupan sehat dan sejahtera (-0,351) berpengaruh negatif terhadap dimensi makna hidup.
Al-Hadith Al-Gharib in the Discourse of Hadith Studies; The Authenticity and The Authority
Authors: Kamil Abdul 
Published: December 2024

This article aims to examine the concept of al-hadith al-Gharib from the perspective of hadith scholars. The primary research questions address: (1) What defines al-hadith al-Gharib in the terminology of hadith science? (2) How can the authenticity of al-hadith al-Gharib be assessed? (3) What are the debates among scholars regarding the authority of al-hadith al-Gharib? This study is categorized as library research, focusing on the concepts of al-hadith al-Gharib, its authenticity, and its authority. The findings indicate that al-hadith al-Gharib refers to a narration reported by a single narrator at any point in the chain of transmission, whether at the beginning, middle, or end of the isnad. Regarding authenticity, al-hadith al-Gharib may be classified as either authentic—such as sahih or hasan hadith—or inauthentic, such as da'if or fabricated hadith. The process of determining the authenticity of al-hadith al-Gharib primarily involves assessing the reliability of the singular narrator and comparing the hadith with other transmission chains. A hadith narrated by a trustworthy individual that does not contradict other reliable traditions is deemed authentic, while contradictory or unreliable narrations are considered weak. Regarding authority, scholars differ in their evaluation of al-hadith al-Gharib . The majority of scholars maintain that al-hadith al-Gharib can serve as a legal basis if it is authentic. In contrast, the Mu'tazilites reject the use of Ahad (single-narrator) hadith as a source of law. Meanwhile, the Hanafi school accepts al-hadith al-Gharib as a legal foundation, provided it is not part of the ‘umum al-balwa (general public affairs).
PERSPECTIVAS SOBRE EL DESARROLLO RURAL: REFLEXIONES, CRÍTICAS Y DESAFÍOS
Authors: Londoño Hernández Huberney 
Published: December 2024

Este escrito adopta un enfoque cualitativo y reflexivo, examinando las perspectivas de reconocidos autores como Theodore W. Schultz, John W. Mellor y Robert Chambers. Estos expertos coinciden en destacar la importancia de la agricultura para el desarrollo económico y la reducción de la pobreza, pero sus énfasis varían, abarcando desde la eficiencia económica hasta la inclusión social y la valorización del conocimiento local. Además, se presentan críticas de autores contemporáneos sobre el modelo convencional y las implicaciones de las estrategias promovidas por organismos internacionales.

Palabras clave: Desarrollo rural, perspectivas, alternativas.
Introducing CCD1 into isolated Rhodotorula strain enhances flavor production and improves cigar fermentation
Authors: Guo Sida , Li Yasen , Zhu Beibei , Zhang Qianying , Yang Zhen , Jia Yun , Zhou Quanwei , Zhang Zhengcheng , Li Dongliang 
Published: December 2024

IntroductionThe fermentation process plays an important role in enhancing the quality of cigar tobacco leaves. Through fermentation, microbial metabolism can degrade aromatic precursors and macromolecules, which increases the content of aroma compounds and reduces irritancy of tobacco leaves.MethodsTo further enhance the fermentation effect of cigar tobacco leaves, a Rhodotorula strain (Rh3), capable of producing carotenoids and improving fermentation quality, was isolated from cigar tobacco leaves. Subsequent genetic engineering techniques introduced the carotenoid cleavage dioxygenase 1 (CCD1) gene into the isolated Rh3.ResultsThe modified Rh3 exhibits a significant increase in carotenoid degradation products compared with the original Rh3 in culture medium (from 0.29 μg/mg to 15 μg/mg). Subsequent cigar tobacco leaf fermentation experiments revealed that the modified Rh3 produced 65.9% more carotenoid degradation products compared to the control group, outperforming the original strain, which achieved a 41.4% increase. Furthermore, the modified strain preserves its ability to improve the intrinsic chemical composition of cigar tobacco leaves.DiscussionWe show here that modified Rh3 can increase the content of carotenoid degradation products, thereby enhancing the fermentation effect of cigar tobacco leaves. This study presents a beneficial exploration to improve the quality of cigar tobacco leaves for future use and offers a promising strategy for producing flavor compounds from discarded tobacco leaves.
Sympathetic innervation of interscapular brown adipose tissue is not a predominant mediator of Oxytocin (OT)-elicited reductions of body weight gain and adiposity in male diet-induced obese rats
Authors: Edwards Melise M. , Nguyen Ha K. , Dodson Andrew D. , Herbertson Adam J. , Honeycutt Mackenzie K. , Slattery Jared D. , Rambousek June R. , Tsui Edison , Wolden-Hanson Tami , Wietecha Tomasz A. , Graham James L. , Tapia Geronimo P. , Sikkema Carl L. , O’Brien Kevin D. , Mundinger Thomas O. , Peskind Elaine R. , Ryu Vitaly , Havel Peter J. , Khan Arshad M. , Taborsky Gerald J. , Blevins James E. 
Published: December 2024

Recent studies indicate that central administration of oxytocin (OT) reduces body weight (BW) in high fat diet-induced obese (DIO) rodents by reducing energy intake and increasing energy expenditure (EE). Previous studies in our lab have shown that administration of OT into the fourth ventricle (4V; hindbrain) elicits weight loss and stimulates interscapular brown adipose tissue temperature (TIBAT) in DIO rats. We hypothesized that OT-elicited stimulation of sympathetic nervous system (SNS) activation of IBAT contributes to its ability to activate BAT and reduce BW in DIO rats. To test this, we determined the effect of disrupting SNS activation of IBAT on OT-elicited stimulation of TIBAT and reduction of BW in DIO rats. We first confirmed that bilateral surgical SNS denervation to IBAT was successful based on having achieved ≥60% reduction in IBAT norepinephrine (NE) content from DIO rats. NE content was selectively reduced in IBAT by 94.7 ± 2.7, 96.8% ± 1.8% and 85.9% ± 6.1% (p &lt; 0.05) at 1, 6 and 7 week post-denervation, respectively, and was unchanged in liver or inguinal white adipose tissue. We then measured the impact of bilateral surgical SNS denervation to IBAT on the ability of acute 4V OT (1, 5 µg) to stimulate TIBAT in DIO rats. We found that the high dose of 4V OT (5 µg) stimulated TIBAT similarly between sham and denervated rats (P=NS) and that the effects of 4V OT to stimulate TIBAT did not require beta-3 adrenergic receptor signaling. We subsequently measured the effect of bilateral surgical denervation of IBAT on the effect of chronic 4V OT (16 nmol/day) or vehicle infusion to reduce BW, adiposity, and energy intake in DIO rats. Chronic 4V OT reduced BW gain by −7.2 ± 9.6 g and −14.1 ± 8.8 g in sham and denervated rats (p &lt; 0.05 vs. vehicle treatment), respectively, and this effect was similar between groups (P=NS). These effects were associated with reductions in adiposity and energy intake (p &lt; 0.05). Collectively, these findings support the hypothesis that sympathetic innervation of IBAT is not required for central OT to increase BAT thermogenesis and reduce BW gain and adiposity in male DIO rats.
Genetic insights into the effect of trace elements on cardiovascular diseases: multi-omics Mendelian randomization combined with linkage disequilibrium score regression analysis
Authors: Chen Bohang , Wang Chuqiao , Li Wenjie 
Published: December 2024

ObjectiveEpidemiological evidence indicates that trace elements are significantly associated with cardiovascular health. However, its causality and underlying mechanisms remain unclear. Therefore, this study aimed to investigate the causal relationship between trace elements and cardiovascular disease, as well as their potential mechanism of action.MethodTwo-sample Mendelian randomization (MR) analyses along with mediated and multivariate MR analyses were employed. These analyses utilized 13 trace elements as exposure variables and 20 cardiovascular diseases as outcome variables, with 4907 circulating plasma proteins, 1400 serum metabolites, 731 immune cell phenotypes, and 473 intestinal flora as potential mediators. The Bayesian weighted MR method was used to validate the MR results, and linkage disequilibrium score regression (LDSC) was applied to explore the genetic correlation between trace elements and cardiovascular disease.ResultOur findings indicated a positive or negative causal relationship between genetically predicted trace elements and cardiovascular disease. An analysis using the Bayesian weighted MR method demonstrated that our causal inference results were reliable. The results of the mediated MR analyses indicate that potassium may reduce the risk of ischemic heart disease by influencing the expression of the plasma proteins BDH2 and C1R. Vitamin B12 may increase the risk of coronary atherosclerosis and cardiovascular death by reducing the levels of VPS29 and PSME1 proteins, while vitamin C may mitigate the risk of cardiac arrest by inhibiting the expression of the TPST2 protein. In addition, potassium can reduce the risk of ischemic heart disease by lowering 4-methoxyphenyl sulfate levels. None of the instrumental variables exhibited pleiotropy in the MR analysis. A sensitivity analysis using the leave-one-out method further confirmed the robustness of our findings. LDSC results indicated a genetic correlation between multiple trace elements and various cardiovascular diseases.ConclusionThis study uncovered the true causal relationship between trace elements and cardiovascular disease risk using genetic methods, and revealed the significant mediating role of specific plasma proteins and metabolites in this relationship.