bluuebunny/crossref_metadata_2025_split huggingface dataset:
Lake-Effect Snowbands in Baroclinic Environments
Authors: Eipper Daniel T. , Greybush Steven J. , Young George S. , Saslo Seth , Sikora Todd D. , Clark Richard D. 
Published: September 2019

Abstract
Lake-effect snowstorms are often observed to manifest as dominant bands, commonly produce heavy localized snowfall, and may extend large distances inland, resulting in hazards and high societal impact. Some studies of dominant bands have documented concomitant environmental baroclinity (i.e., baroclinity occurring at a scale larger than the width of the parent lake), but the interaction of this baroclinity with the inland structure of dominant bands has been largely unexplored. In this study, the thermodynamic environment and thermodynamic and kinematic structure of simulated dominant bands are examined using WRF reanalyses at 3-km horizontal resolution and an innovative technique for selecting the most representative member from the WRF ensemble. Three reanalysis periods are selected from the Ontario Winter Lake-effect Systems (OWLeS) field campaign, encompassing 185 simulation hours, including 155 h in which dominant bands are identified. Environmental baroclinity is commonly observed during dominant-band periods and occurs in both the north–south and east–west directions. Sources of this baroclinity are identified and discussed. In addition, case studies are conducted for simulation hours featuring weak and strong along-band environmental baroclinity, resulting in weak and strong inland extent, respectively. These contrasting cases offer insight into one mechanism by which along-band environmental baroclinity can influence the inland structure and intensity of dominant bands: in the case with strong environmental baroclinity, inland portions of this band formed under weak instability and therefore exhibit slow overturning, enabling advection far inland under strong winds, whereas the nearshore portion forms under strong instability, and the enhanced overturning eventually leads to the demise of the inland portion of the band.
Elevated proportion of collapsed microvessels indicate poor survival outcome in patients with non-small cell lung cancer
Authors: Tong Ying-hui , He Ying , Hu Lu-ying , Liu Yu-jia , Zheng Xiao-wei , Sun Jiao , Song Yu , Zhang Yi-wen , Fang Luo , Huang Ping 
Published: September 2019

Background: An integral and well-functioning vascular system is essential for tumor progression and chemotherapy infusion. However, the lumen integrity of the microvessels and its significance in prognosis has not been studied. In this study, we found that the proportion of collapsed microvessels is suggested to be a novel biomarker for predicting prognosis in patients with non-small cell lung cancer (NSCLC). Methods: In this study, immunohistochemical CD31 staining was performed to identify the microvessels in tumor specimens. Proportions of collapsed vessels were estimated in CD31-stained tumor specimens from 100 patients with NSCLC. The correlation between collapsed microvessel proportion and survival time were evaluated by univariate and multivariate analysis. Results: Data from 99 patients were analyzed and a wide range of collapse–microvessel fraction was observed in 96 patients (1.4%–70%). Elevated collapse proportion (⩾6.5%) indicated poor overall survival in both univariate analysis ( p = 0.042) and multivariate analysis ( p = 0.014). Conclusions: Elevated proportion of collapsed microvessels indicted poor survival outcome in patients with NSCLC.
Terazosin or baclofen in young men with chronic orchialgia: A cohort study of 499 patients
Authors: Mohseni-Rad Hamed , Razzaghdoust Abolfazl , Mishan Mohammad Amir , Gholamrezaie Hamid Reza , Hosseinkhani Ali 
Published: September 2019

Purpose: We aimed to investigate the comparative efficacy of terazosin and baclofen in young men with chronic orchialgia using National Institutes of Health Chronic Prostatitis Symptom Index measurement. Patients and methods: Of 499 young men with chronic orchialgia, 255 received a daily 2 mg terazosin at bedtime and 244 received 10 mg baclofen during a period of 3 months. A daily 10-min hot-tub hip-bath rest was administered for all patients. Moreover, all patients with grade 3 and 18 patients with grade 2 varicocele underwent varicocelectomy. The National Institutes of Health Chronic Prostatitis Symptom Index score was assessed at baseline and 3 months later. Results: Both terazosin and baclofen groups experienced a significant reduction in mean National Institutes of Health Chronic Prostatitis Symptom Index score (24.78 and 24.81 at baseline to 19.68 and 19.60 after the treatment for terazosin and baclofen groups, respectively). However, there was no significant difference between the groups with regard to post-treatment National Institutes of Health Chronic Prostatitis Symptom Index score after adjustment for the pre-treatment score ( p = 0.987). A total of 85 patients (33.4%) in terazosin group and 74 patients (30.3%) in baclofen group underwent varicocelectomy. Addition of the varicocelectomy to the treatment as a multimodal approach had no further improvement in the National Institutes of Health Chronic Prostatitis Symptom Index score. Conclusion: Although a significant reduction was observed in mean National Institutes of Health Chronic Prostatitis Symptom Index score for both terazosin and baclofen groups, there was no significant difference between the treatments. Moreover, addition of varicocelectomy to terazosin or baclofen could not significantly decrease National Institutes of Health Chronic Prostatitis Symptom Index score; thus, varicocelectomy may not be appropriate for men who have some success with medical management. Further randomized studies are warranted.
Dual corneal involvement by endothelial and epithelial corneal dystrophies in Steinert’s disease: A case of triple dystrophy
Authors: Gargallo-Benedicto Amparo , Pérez-Torregrosa Vicente Tomás , Clemente-Tomás Rodrigo , Duch-Samper Antonio Miguel 
Published: September 2019

Introduction: A case of dual corneal involvement due to Fuchs endothelial corneal dystrophy and epithelial basement membrane corneal dystrophy in a patient with Steinert’s myotonic dystrophy type 1 is described, and a literature review on the triple association is made. Case description: A 52-year-old male diagnosed with myotonic dystrophy type 1 presented due to progressive bilateral vision loss during the past year. A full ophthalmological evaluation was made, with biomicroscopy, funduscopy, anterior segment optical coherence tomography, and endothelial cell count using specular microscopy. Exploration revealed bilateral superior palpebral ptosis, visual acuity 0.5 in the right eye and 0.3 in the left eye, and with an intraocular pressure of 11 and 10 mmHg, respectively. Biomicroscopy revealed map-dot-fingerprint lesions characteristic of epithelial basement membrane corneal dystrophy in both eyes, as well as abundant endothelial guttae due to Fuchs endothelial corneal dystrophy (stage II) and bilateral nuclear and posterior subcapsular cataracts. Specular microscopy in turn showed cell loss and a destructured endothelial map. Finally, anterior segment optical coherence tomography revealed the accumulation of epithelial basement membrane and hyperreflective endothelial excrescences corresponding to guttae. Conclusion: The association of Fuchs endothelial corneal dystrophy with myotonic dystrophy has been described and explained by a common genetic basis in the expansion of a CTG trinucleotide repeat, though this is the first reported case of the triple association of Fuchs endothelial corneal dystrophy, epithelial basement membrane corneal dystrophy, and myotonic dystrophy type 1. New mutations or still unknown genetic alterations could possibly explain the triple association reported in our case.
Hsa_circ_0005075 promotes the proliferation and invasion of colorectal cancer cells
Authors: Zhong Di , Li Peng , Gong Pei-yao 
Published: September 2019

Background: Aberrant expression of circular RNAs (circRNAs) is implicated in tumorigenesis and disease progression. However, the underlying molecular mechanisms and physiological functions of hsa_circ_0005075 in human colorectal cancer are still poorly understood. Methods: Quantitative real-time PCR (qRT-PCR) was performed to detect the expression level of hsa_circ_0005075 in colorectal cancer. Correlations of hsa_circ_0005075 expression with pathological parameters and overall survival were assessed. CCK-8 and Transwell invasion assays were utilized to determine the effect of hsa_circ_0005075 on proliferation and invasion of colorectal cancer cells. Results: Hsa_circ_0005075 was overexpressed in colorectal cancer tissues compared with paracancerous tissues and intestinal polyps. Its expression level was associated with distal metastasis, invasion, tumor node metastasis stage, and tumor diameter in colorectal cancer, and was negatively correlated with overall survival of patients with colorectal cancer. Moreover, enforced expression of hsa_circ_0005075 potentiated the proliferation and invasive behavior of colorectal cancer cells. Conclusions: Our findings suggested that hsa_circ_0005075 expression was increased in colorectal cancer and might serve as a promising diagnostic mark and therapy target of colorectal cancer.
“I Wish Someone Had Told Me That Could Happen”: A Thematic Analysis of Patients’ Unexpected Experiences With End-Stage Kidney Disease Treatment
Authors: DePasquale Nicole , Cabacungan Ashley , Ephraim Patti L , Lewis-Boyér LaPricia , Diamantidis Clarissa J , Powe Neil R , Boulware L Ebony 
Published: September 2019

Background: Preparedness regarding prognosis and treatment options enables patients to cope with uncertainties, make value-based treatment decisions, and set treatment goals. Yet, little is known about the expectedness of end-stage kidney disease (ESKD) patients’ treatment experiences beyond their desire for better treatment education. Objective: To describe unexpected adverse treatment experiences among ESKD patients. Method: The authors conducted 7 focus groups with 55 dialysis patients and living-donor kidney transplantation recipients receiving medical care in Baltimore, Maryland. Data were analyzed thematically. Themes present in different treatment groups were highlighted to provide insight into common experiences. Results: The authors identified 5 themes: (1) psychological reactions, (2) constrained freedom of choice, (3) treatment delivery and logistics, (4) morbidity, and (5) finances. Conclusion: Patients were unprepared for nonclinical, logistical, and clinical aspects of ESKD treatment. The need for providers’ use of tailored preparatory techniques and the development of pretreatment interventions to help patients know what to expect from and feel psychologically prepared for treatment, particularly with respect to nonclinical implications, is critical. These efforts have great potential to improve patients’ treatment experiences.
Clinical effect on uncontrolled asthma using a novel digital automated self-management solution: a physician-blinded randomised controlled crossover trial
Authors: Ljungberg Henrik , Carleborg Anna , Gerber Hilmar , Öfverström Christina , Wolodarski Jakob , Menshi Faiza , Engdahl Mikaela , Eduards Marianne , Nordlund Björn 
Published: September 2019

IntroductionAsthmaTuner is a novel self-management system consisting of a patient app, a cloud-based storage solution and a healthcare interface. Patients use Bluetooth spirometers to measure lung function (forced expiratory volume in 1 s) and can register symptoms. They then receive immediate feedback on asthma control and an image of the correct inhaler(s) to use and the dose. The aim of this pilot study was to evaluate the effect of AsthmaTuner on symptom control and adherence compared with conventional treatment.Material and methodsThis multicentre physician-blinded crossover trial randomised patients in two groups that started with 8 weeks of AsthmaTuner or conventional treatment using a personalised printed treatment plan, with 2 weeks of washout between the crossover treatments. Participants in a primary or paediatric care setting in Sweden with asthma diagnosis, uncontrolled symptoms and Asthma Control Test (ACT) score <20 points were included. Symptom control was analysed using t-tests for the difference between the group means of the sums of ACT scores at each treatment end-visit, with 95% confidence intervals. Medical Adherence Report Scale (MARS) scores captured differences in adherence (remembering to take asthma medication) between treatment periods.ResultsThe study population consisted of 77 patients (60% females). The ACT score significantly improved with AsthmaTuner compared with conventional treatment (mean ACT difference 0.70, 95% CI 0.06–1.34; p=0.03). Adherence did not improve significantly in all participants, but did improve among those in primary care who used AsthmaTuner an average of once a week or more compared with conventional treatment (mean MARS difference 0.45, 95% CI 0.13–0.77; p=0.01).ConclusionsAsthmaTuner improved symptom control in patients with uncontrolled asthma compared with conventional treatment.
Circular RNA circ-ZKSCAN1 inhibits bladder cancer progression through miR-1178-3p/p21 axis and acts as a prognostic factor of recurrence
Authors: Bi Junming , Liu Hongwei , Dong Wei , Xie Weibin , He Qingqing , Cai Zijian , Huang Jian , Lin Tianxin 
Published: September 2019

Abstract

Background
Circular RNAs (circRNAs) represent a subclass of regulatory RNAs that have been shown to have significant regulatory roles in cancer progression. However, the biological functions of circRNAs in bladder cancer (BCa) are largely unknown.

Methods
Cell invasion models were established, and invasion-related circRNAs were detected by qPCR. Using above method, circ-ZKSCAN1 was picked out for further study. Circ-ZKSCAN1 expression and survival analyses were performed through qPCR. The survival curves were generated by the Kaplan-Meier method, and the log-rank test was used to assess the significance. Cell proliferation, migration and invasion were examined to investigate the function of circ-ZKSCAN1. Tumorigenesis in nude mice was assessed to determine the effect of circ-ZKSCAN1 in bladder cancer. Biotin-coupled probe pull-down assays, FISH and luciferase reporter assays were conducted to confirm the relationship between circ-ZKSCAN1 and microRNA. RNA-seq revealed different molecular changes in downstream genes.

Results
Here, we found that circ-ZKSCAN1 was downregulated in BCa tissues and cell lines. Circ-ZKSCAN1 levels were associated with survival, tumor grade, pathological T stage and tumor recurrence. Overexpressed circ-ZKSCAN1 inhibits cell proliferation, migration, invasion and metastasis in vitro and in vivo. Mechanistically, we demonstrated that circ-ZKSCAN1 upregulated p21 expression by sponging miR-1178-3p, which suppressed the aggressive biological behaviors in bladder cancer.

Conclusions
These results reveal that Circ-ZKSCAN1 acts as a tumor suppressor via a novel circ-ZKSCAN1/miR-1178-3p/p21 axis, which have the important role in the proliferation, migration and invasion ablitities of BCa cells and provide a novel perspective on circRNAs in BCa progression.
Use of Endocrine Therapy for Breast Cancer Risk Reduction: ASCO Clinical Practice Guideline Update
Authors: Visvanathan Kala , Fabian Carol J. , Bantug Elissa , Brewster Abenaa M. , Davidson Nancy E. , DeCensi Andrea , Floyd Justin D. , Garber Judy E. , Hofstatter Erin W. , Khan Seema A. , Katapodi Maria C. , Pruthi Sandhya , Raab Rachal , Runowicz Carolyn D. , Somerfield Mark R. 
Published: September 2019

PURPOSE To update the ASCO guideline on pharmacologic interventions for breast cancer risk reduction and provide guidance on clinical issues that arise when deciding to use endocrine therapy for breast cancer risk reduction. METHODS An Expert Panel conducted targeted systematic literature reviews to identify new studies. RESULTS A randomized clinical trial that evaluated the use of anastrozole for reduction of estrogen receptor–positive breast cancers in postmenopausal women at increased risk of developing breast cancer provided the predominant basis for the update. UPDATED RECOMMENDATIONS In postmenopausal women at increased risk, the choice of endocrine therapy now includes anastrozole (1 mg/day) in addition to exemestane (25 mg/day), raloxifene (60 mg/day), or tamoxifen (20 mg/day). The decision regarding choice of endocrine therapy should take into consideration age, baseline comorbidities, and adverse effect profiles. Clinicians should not prescribe anastrozole, exemestane, or raloxifene for breast cancer risk reduction to premenopausal women. Tamoxifen 20 mg/day for 5 years is still considered standard of care for risk reduction in premenopausal women who are at least 35 years old and have completed childbearing. Data on low-dose tamoxifen as an alternative to the standard dose for both pre- and postmenopausal women with intraepithelial neoplasia are discussed in the Clinical Considerations section of this article. Additional information is available at www.asco.org/breast-cancer-guidelines .
Prevalence and Predictors of Cisplatin-Induced Peripheral Neuropathy at the Kenyatta National Hospital
Authors: Ezzi Mohammed S. , Othieno-Abinya Nicholas A. , Amayo Erastus , Oyiro Peter , McLigeyo Angela , Yatich Robert Bett , Shoba Bonginkosi 
Published: September 2019

PURPOSE To determine the prevalence, predictors, and/or risk factors of chemotherapy-induced peripheral neuropathy in patients undergoing chemotherapy with cisplatin at Kenyatta National Hospital, Nairobi, Kenya. METHODS This was a cross-sectional analysis of patients who underwent chemotherapy with cisplatin for at least 2 months at Kenyatta National Hospital oncology units. Peripheral neuropathy was determined by history and physical examination per the protocol. Data are presented in tables. Descriptive inferential statistics such as means, medians, and proportions were determined where applicable. RESULTS We recruited 67 patients who were undergoing chemotherapy with cisplatin. Fifty-six patients (83.6%) had peripheral neuropathy. Forty-five patients (81%) had mild-grade (grades 1 and 2) peripheral neuropathy. Only two patients (3.1%) had grade 4 neuropathy. Almost all patients who were overweight or obese developed peripheral neuropathy. CONCLUSION Peripheral neuropathy among patients receiving cisplatin is quite prevalent at Kenyatta National Hospital (83.6% prevalence rate). However, most of the patients had a mild grade of neuropathy, which is largely consistent with literature elsewhere.
Um presente sem porvir
Authors: Ovidio Lara 
Published: September 2019

O futuro é conhecido, mas não aconteceu ainda, duas afirmações evidentes que convivem e criam a tensão em torno da qual se desenvolve este texto. Aparecem sobrepostos o tempo da história e o tempo do indivíduo. O presente ora se apresenta como tempo de impossibilidades, ora como tempo de incertezas. Não há chão: ninguém mais sabe como olhar para o presente, ninguém mais tem tempo de aprender do passado. É preciso uma novidade realmente nova. O acontecimento parece apontar uma saída. No entanto, lembramos rapidamente que a ciência lacrou todas as saídas de emergência. O movimento do presente é o de correr muito depressa pelos escombros do futuro.Palavras-chave: Tempo, Futuro, Arte Contemporânea, IncertezaAbstract: The future is known, but it has not happened yet. Two clear statements, which coexist and create the tension that guides the development of this text. History’s time and the time of the self overlap. The present presents itself sometimes as a time of impossibilities, sometimes as a time of uncertainties. There is no ground: nobody knows how to look at the present anymore, and nobody has the time to learn from the past. Some kind of new indeed novelty is in order. The event seems to point to an exit. However, we quickly remember that science has sealed all emergency exits. The present’s movement is to run really fast through the debris of the future.Keywords: Time, Future, Contemporary Art, Uncertainty
O contexto epistêmico do museu de da história da arte a partir de uma abordagem decolonial
Authors: Estelita Marian 
Published: September 2019

Buscaremos refletir sobre o contexto epistêmico que norteia o museu e a história da arte como estruturas legitimadas de produção de conhecimento. A partir de abordagens decolonais e pós estruturalistas, desejamos problematizar a existência de um pensamento supostamente universal, enfatizando o caráter lateralizado, temporal e geograficamente localizado das práticas metodológicas perpetradas pela modernidade.Palavras-chave: decolonialismo, universalidade, museu, história da arte.The epistemic context of museum and art history from a decolonial approach AbstractWe intend to reflect about the epistemic context that involves the museum and art history as legitimated structures of knowledge production. From decoloniality and post structuralist approach, we want to problematize the existence of an universal thinking, emphasizing the partial, temporal and geographic character of the methodological praxis, developed by the modernity. Key-words: decoloniality, universality, museum, art history.
Cine en la 4ta Reunión de Arte Contemporáneo
Authors: Cine Documental Cuaderno de 
Published: September 2019

En el mes de octubre de 2018 se realizó en la Universidad Nacional del Litoral la 4a Reunión de Arte Contemporáneo. En este marco se realizó una Mesa de Discusión sobre Cine Contemporáneo, con la participación de Mariano Llinás y Agustín Falco. En las semanas previas, como preparación para esa discusión, se proyectó La Flor, la obra monumental de Llinás.
PERSEPSI SISWA SEKOLAH MENENGAH ATAS DAERAH ISTIMEWA YOGYAKARTA TERHADAP JURUSAN PERBANDINGAN AGAMA
Authors: Ismail Roni 
Published: September 2019

The Department of Comparative Religion was established since 1961 as a center for the study of various religions and to promote brotherhood, humanity, and tolerance in the midst of religious plurality. This department was present to answer the basic needs of this pluralistic nation. However, the Department of Comparative Religion is not attracted many “market” including by the stu- dents from schools in Yogyakarta. This study aims to assess the perception of high school students in Yog yakarta which may be the cause of low interest in the study in this department. Data were collected by questionnaire (Summated Rating of Likert) which was distributed to 9 schools in Yog yakarta, each school 10 students were taken as samples. Analysis of the data processed with SPSS version 16. The results showed that students’ perceptions of the Department of Comparative Religion is Good with size <62.50 -> 81.25; 63.3% of respondents was aware of this and looking at the Department of Compara- tive Religion as the department of interest, 74.4% stated studied at the Department will strengthen the commitment of Islam, 81.1% regard this department is ver y important for Indonesian as a pluralistic nation. Therefore, 77.8% of respondents stated that the Comparative Religion as the name of department should be maintained. The factors that cause them to have a certain perception of the Department are: 21% of respondents are influenced by friends, 12.2% of respondents by teachers/preachers/cleric, 12.2% by parents, and 42.2% by social media for no lectures on Comparative Religion. Causative factor they are not intending to study in the Comparative Religion is not be- cause the name of the Department, but because of the employment prospects; 46.6% of respondents said the prospect of the department’s graduate employment is narrow, and 55.6% regard it as not in accordance with their dream. Although 76.7% of the respondents saw the name of Comparative Religion does not lead to the emergence of a negative perception, but 71.1% proposed to change the name the Department to reduce misunderstanding among wider community.