bluuebunny/crossref_metadata_2025_split huggingface dataset:
Problem-solving training: assessing the feasibility and acceptability of delivering and evaluating a problem-solving training model for front-line prison staff and prisoners who self-harm
Authors: Perry Amanda , Waterman Mitchell Glenn , House Allan , Wright-Hughes Alexandra , Greenhalgh Joanne , Farrin Amanda , Richardson Gerry , Hopton Ann Kathryn , Wright Nat 
Published: October 2019

ObjectivesProblem-solving skills training is adaptable, inexpensive and simple to deliver. However, its application with prisoners who self-harm is unknown. The study assessed the feasibility and acceptability of a problem-solving training (PST) intervention for prison staff and prisoners who self-harm, to inform the design of a large-scale study.Design and settingA mixed-methods design used routinely collected data, individual outcome measures, an economic protocol and qualitative interviews at four prisons in Yorkshire and Humber, UK.Participants(i) Front-line prison staff, (ii) male and female prisoners with an episode of self-harm in the previous 2 weeks.InterventionThe intervention comprised a 1 hour staff training session and a 30 min prisoner session using adapted workbooks and case studies.OutcomesWe assessed the study processes—coverage of training; recruitment and retention rates and adequacy of intervention delivery—and available data (completeness of outcome data, integrity of routinely collected data and access to the National Health Service (NHS) resource information). Prisoner outcomes assessed incidence of self-harm, quality of life and depression at baseline and at follow-up. Qualitative findings are presented elsewhere.ResultsRecruitment was higher than anticipated for staff n=280, but lower for prisoners, n=48. Retention was good with 43/48 (89%) prisoners completing the intervention, at follow-up we collected individual outcome data for 34/48 (71%) of prisoners. Access to routinely collected data was inconsistent. Prisoners were frequent users of NHS healthcare. The additional cost of training and intervention delivery was deemed minimal in comparison to ‘treatment as usual’. Outcome measures of self-harm, quality of life and depression were found to be acceptable.ConclusionsThe intervention proved feasible to adapt. Staff training was delivered but on the whole it was not deemed feasible for staff to deliver the intervention. A large-scale study is warranted, but modifications to the implementation of the intervention are required.
Remuneration of primary dental care in England: a qualitative framework analysis of perspectives of a new service delivery model incorporating incentives for improved access, quality and health outcomes
Authors: Robinson Peter G , Douglas Gail V A , Gibson Barry J , Godson Jenny , Vinall-Collier Karen , Pavitt Sue , Hulme Claire 
Published: October 2019

ObjectiveThis study aimed to describe stakeholder perspectives of a new service delivery model in primary care dentistry incorporating incentives for access, quality and health outcomes.DesignData were collected through observations, interviews and focus groups.SettingThis was conducted under six UK primary dental care practices, three working under the incentive-driven contract and three working under the traditional activity-based contract.ParticipantsObservations were made of 30 dental appointments. Eighteen lay people, 15 dental team staff and a member of a commissioning team took part in the interviews and focus groups.ResultsUsing a qualitative framework analysis informed by Andersen’s model of access, we found oral health assessments influenced patients’ perceptions of need, which led to changes in preventive behaviour. Dentists responded to the contract, with greater emphasis on prevention, use of the disease risk ratings in treatment planning, adherence to the pathways and the utilisation of skill-mix. Participants identified increases in the capacity of practices to deliver more care as a result. These changes were seen to improve evaluated and perceived health and patient satisfaction. These outcomes fed back to shape people’s predispositions to visit the dentist.ConclusionThe incentive-driven contract was perceived to increase access to dental care, determine dentists’ and patients’ perceptions of need, their behaviours, health outcomes and patient satisfaction. Dentists face challenges in refocusing care, perceptions of preventive dentistry, deployment of skill mix and use of the risk assessments and care pathways. Dentists may need support in these areas and to recognise the differences between caring for individual patients and the patient-base of a practice.
Clinical approach to equine neuro‐ophthalmology
Authors: Pont Roser Tetas , Beltran Elsa 
Published: October 2019

Background: Neuro‐ophthalmic disorders, although still uncommon, are being reported more often in horses. Cases can present with a wide range of clinical signs, from chronic, non‐healing corneal ulcers to behavioural changes due to visual impairment. Achieving the correct diagnosis is not always easy. Using a systematic approach to examine horses with suspected neuro‐ophthalmic disorders will help the clinician to achieve a neuroanatomic diagnosis and a list of differential diagnoses. The diagnostic tests are always planned based on this list of differentials and the treatment is targeted to the final or most likely diagnosis. Understanding the neuro‐ophthalmic anatomy is mandatory to achieve the correct neurolocalisation and plan the appropriate diagnostic modalities.Aim of the article: This article reviews the most important neuro‐ophthalmic pathways to interpret the clinical signs and underlying causes seen in this field.
Coronary risk stratification of patients with newly diagnosed heart failure
Authors: Hasselbalch Rasmus Bo , Pries-Heje Mia , Engstrøm Thomas , Sandø Andreas , Heitmann Merete , Pedersen Frants , Schou Morten , Mickley Hans , Elming Hanne , Steffensen Rolf , Koeber Lars , Iversen Kasper Karmark 
Published: October 2019

ObjectiveCoronary artery disease (CAD) is frequent in patients with newly diagnosed heart failure (HF). Multislice CT (MSCT) is a non-invasive alternative to coronary angiography (CAG) suggested for patients with a low-to-intermediate risk of CAD. No established definition of such patients exists. Our purpose was to develop a simple score to identify as large a group as possible with a suitable pretest risk of CAD.MethodsRetrospective study of patients in Denmark undergoing CAG due to newly diagnosed HF from 2010 to 2014. All Danish patients were registered in two databases according to geographical location. We used data from one registry and multiple logistic regression with backwards elimination to find predictors of CAD and used the derived OR to develop a clinical risk score called the CT-HF score, which was subsequently validated in the other database.ResultsThe main cohort consisted of 2171 patients and the validation cohort consisted of 2795 patients with 24% and 27% of patients having significant CAD, respectively. Among significant predictor, the strongest was extracardiac arteriopathy (OR 2.84). Other significant factors were male sex, smoking, hyperlipidaemia, diabetes mellitus, angina and age. A proposed cut-off of 9 points identified 61% of patients with a 15% risk of having CAD, resulting in an estimated savings of 15% of the cost and 21% of the radiation.ConclusionsA simple score based on clinical risk factors could identify HF patients with a low risk of CAD; these patients may have benefitted from MSCT as a gatekeeper for CAG.
Investigating multiple solutions to boundary value problems in constrained minimal and non-minimal SUSY models
Authors: Meuser Daniel , Voigt Alexander 
Published: October 2019

Abstract
We investigate the physical origins of multiple solutions to boundary value problems in the fully constrained MSSM and NMSSM. We derive mathematical criteria that formulate circumstances under which multiple solutions can appear. Finally, we study the validity of the exclusion of the CMSSM in the presence of multiple solutions.
Non-rational varieties with the Hilbert Property
Authors: Demeio Julian Lawrence 
Published: October 2019

A variety [Formula: see text] over a field [Formula: see text] is said to have the Hilbert Property if [Formula: see text] is not thin. We shall exhibit some examples of varieties, for which the Hilbert Property is a new result.We give a sufficient condition for descending the Hilbert Property to the quotient of a variety by the action of a finite group. Applying this result to linear actions of groups, we exhibit some examples of non-rational unirational varieties with the Hilbert Property, providing positive instances of a conjecture posed by Colliot–Thélèene and Sansuc. We also give a sufficient condition for a surface with two elliptic fibrations to have the Hilbert Property, and use it to prove that a certain class of K3 surfaces have the Hilbert Property, generalizing a result of Corvaja and Zannier.
Cardiovascular Outcomes Associated With Clinical Use of Citalopram and Omeprazole: A Nationwide Population‐Based Cohort Study
Authors: Wu Wen‐Tung , Tsai Chun‐Teng , Chou Yu‐Ching , Ku Po‐Ming , Chen Yong‐Chen , You San‐Lin , Hung Chi‐Feng , Sun Chien‐An 
Published: October 2019

Background

Recent studies have raised concerns about the reduced efficacy of citalopram when used concurrently with proton pump inhibitors. The aim of this study was to evaluate the associations between clinical use of citalopram and omeprazole and the risk of sudden cardiac arrest (
SCA
) in an Asian population.

Methods and Results

A retrospective cohort study was conducted using the National Health Insurance Research Database of Taiwan dated from 2000 to 2013. The study cohorts comprised 3882 patients with citalopram use alone, 31 090 patients with omeprazole use alone, and 405 patients with concomitant use of citalopram and omeprazole (as the exposed cohort), and 141 508 patients received treatment with antidepressants without the risk of
SCA
and/or proton pump inhibitors other than omeprazole (as the comparison cohort). The primary outcome was the occurrence of
SCA
. The hazard ratios and 95%
CI
s derived from the time‐dependent Cox regression model were used to assess the association between the proposed drug treatments and risk of
SCA
. The adjusted hazard ratios of
SCA
was 1.32 (95%
CI
, 1.17–1.50) for citalopram use alone, 1.08 (95%
CI
, 0.98–1.20) for omeprazole use alone, and 2.23 (95%
CI
, 1.79–2.78) for concomitant use of citalopram and omeprazole. The cumulative incidence of
SCA
over the Kaplan‐Meier curves was more pronounced in patients with concomitant use of citalopram and omeprazole than those treated with citalopram alone and omeprazole alone.

Conclusions

This cohort study demonstrated use of citalopram and omeprazole either in isolation use or in concomitant use to be at increased risk for
SCA
.
Shift Workers Have Higher Blood Pressure Medicine Use, But Only When They Are Short Sleepers: A Longitudinal UK Biobank Study
Authors: Riegel Barbara , Daus Marguerite , Lozano Alicia J. , Malone Susan K. , Patterson Freda , Hanlon Alexandra L. 
Published: October 2019

Background

Some, but not all, studies report associations between shift work and hypertension, suggesting that particular subgroups may be at risk. We examined moderating effects of sleep duration and circadian preference on the relationship between shift work and new blood pressure (
BP
) medicine use at follow‐up.

Methods and Results

Baseline and 5‐year follow‐up data from the
UK
Biobank cohort (N=9200) were used to generate logistic regression models for shift workers and nonshift workers. The moderating effects of sleep duration (short ≤6 hours; adequate 7–8 hours; long ≥9 hours) and circadian preference (morning “larks;” intermediate; evening “owls”) at baseline were examined with new
BP
medicine use at follow‐up, adjusting for age, sex, race, education, employment, urban/rural, cardiovascular disease family history, depression, alcohol intake, physical activity, diet, smoking, and body mass index. The sample was predominately middle aged (55.3±7.4), female (57.3%), and white (97.9%). Most reported adequate sleep duration (7–8 hours, 73.7%) and were intermediate type (65.3%); 8.0% were shift workers at baseline. Only 6.5% reported new
BP
medicine use at follow‐up. Short sleep duration was a significant moderator of new
BP
medicine use in shift workers. Among short sleepers, shift workers had a 2.1‐fold increased odds of new
BP
medicine use compared with nonshift workers (odds ratio=2.08, 95%
CI
=1.21–3.58,
P
=0.008). In those reporting adequate (odds ratio=0.82, 95%
CI
=0.54–1.25,
P
=0.35) and long sleep (odds ratio=0.64, 95%
CI
=0.11–3.54,
P
=0.60), this relationship was protective but nonsignificant. Interaction between circadian preference and shift work on
BP
medicine use was nonsignificant.

Conclusions
Shift workers with short sleep duration may be at risk for hypertension.
Diagnostic accuracy of dual-energy CT for detection of bone marrow lesions in the subacutely injured knee with MRI as reference method
Authors: Björkman Ann-Sofi , Koskinen Seppo K , Lindblom Maria , Persson Anders 
Published: October 2019

Background Dual-energy computer tomography (DECT) can detect post-traumatic bone marrow lesions. Prospective studies of the knee with large numbers of participants and intra-observer agreement assessment are limited. Purpose To investigate the diagnostic accuracy of DECT in detecting bone marrow lesions as well as estimating the bone marrow lesion volume in patients with suspected anterior cruciate ligament trauma with magnetic resonance imaging (MRI) as reference standard. Material and Methods Forty-eight consecutive patients with suspected anterior cruciate ligament injury were imaged bilaterally with DECT within a mean of 25 days (range 4–55 days) following injury and MRI within seven days of DECT. Two readers analyzed DECT virtual non-calcium-blinded images. Consensus MRI was reference standard. Intra- and inter-observer agreement were determined using weighted kappa statistics. Sensitivity, specificity, and negative and positive predictive values were calculated. Bone marrow lesion volumes were measured; for comparison, intra-class correlation coefficient was used. Results The 48 patients (26 men, 22 women; mean age 23 years, age range 15–37 years) were imaged bilaterally yielding 52 knees with bone marrow lesions, of which 44 were in the femur and 41 were in the tibia. Intra- and inter-observer agreement to detect bone marrow lesions was moderate and fair to moderate (κ 0.54–0.66, 95% confidence interval [CI] 0.39–0.80 and 0.37–0.41, 95% CI 0.20–0.57) and overall sensitivity and specificity were 70.1% and 69.1%, respectively. Positive and negative predictive values were 72.9% and 66.1%, respectively. Bone marrow lesion volumes showed excellent intra- and inter-observer agreement (0.83–0.91, 95% CI 0.74–0.94 and 0.76–0.78, 95% CI 0.57–0.87). Conclusion The diagnostic performance of DECT to detect bone marrow lesions in the subacutely injured knee was moderate with intra- and inter-observer agreement ranging from moderate to substantial and fair to moderate. Bone marrow lesion volume correlation was excellent.
A systematic review of the cross-cultural adaptations and measurement properties of the Shoulder Pain and Disability Index
Authors: Furtado Rochelle , Nazari Goris , MacDermid Joy C 
Published: October 2019

Introduction The shoulder is the leading site of musculoskeletal pain. Patient-reported outcomes, such as the Shoulder Pain and Disability Index (SPADI), allow us to assess shoulder pain in a clinical setting. Since the SPADI was developed in English, many cultures have cross-culturally adapted the SPADI for clinical use. The purpose of this review was to assess the translation and cross-cultural adaptation procedures and measurement properties of the adapted SPADI. Methods A systematic review was performed on cultural adaptations of the SPADI accessible through MEDLINE, CINAHL, EMBASE and/or Google Scholar. Included were prospective cohort studies that used an adapted version of the SPADI. All studies were evaluated according to the guidelines for cross-cultural adaptations and the guidelines for measurement properties. Results The search retrieved 19 studies that met the inclusion criteria. According to the recommended guidelines for cross-cultural adaptations, 16 studies performed 100% of the steps and 1 study performed 80% of the steps. When evaluating the studies’ psychometric properties based on the quality criteria, none of the studies reported all recommended measurement properties. The measurement property of reliability was reported fully by 74% of studies. Internal consistency was fully reported by 74% of studies. None of the studies were able to fully report responsiveness, agreement and/or construct validity. Conclusions Whilst the majority of studies followed proper translation procedures, testing of the measurement properties were inadequate. Therefore, it is recommended that the current adapted versions of the SPADI undergo further evaluation before use in clinical practice.
Donor T-cell–derived GM-CSF drives alloantigen presentation by dendritic cells in the gastrointestinal tract
Authors: Gartlan Kate H. , Koyama Motoko , Lineburg Katie E. , Chang Karshing , Ensbey Kathleen S. , Kuns Rachel D. , Henden Andrea S. , Samson Luke D. , Clouston Andrew D. , Lopez Angel F. , MacDonald Kelli P. A. , Hill Geoffrey R. 
Published: October 2019

Key Points
GM-CSF is derived from both Th17/Tc17-positive and Th17/Tc17-negative donor lineages after bone marrow transplantation. GM-CSF promotes the accumulation of alloantigen-presenting, migratory donor DCs in the gastrointestinal tract during GVHD.
Changes in serum markers of patients with PCOS during consecutive clomiphene stimulation cycles: a retrospective study
Authors: Hager Marlene , Hörath Steffen , Frigo Peter , Koch Marianne , Marculescu Rodrig , Ott Johannes 
Published: October 2019

Abstract

Background
A retrospective case-control study was performed to evaluate whether PCOS-specific serum markers would change in women with polycystic ovary syndrome (PCOS) during the course of two consecutive cycles of clomiphene citrate (CC)-stimulation, which did not lead to a pregnancy.

Methods
Anovulatory PCOS patients who underwent two consecutive CC-cycles (n = 41) and anovulatory PCOS controls who chose an observational approach for two months (n = 24) were included in the study. The main outcome measures were levels of follicle stimulating hormone (FSH), luteinizing hormone (LH), anti-Mullerian hormone (AMH), total testosterone, androstenedione, and sexual hormone binding globulin (SHBG).

Results
In the control group, PCOS-specific serum parameters did not change during two months (p > 0.05). In the CC-group, there were decreases in LH (11.8 ± 4.9 mU/mL vs. 10.9 ± 4.0 mU/mL; p = 0.029), the LH:FSH ratio (2.1 ± 0.8 mU/mL vs. 1.8 ± 0.5 mU/mL; p = 0.007), and AMH (8.08 ± 4.27 ng/mL vs. 7.17 ± 3.37 ng/mL; p = 0.011), as well as an increase in SHBG (46.0 ± 20.2 nmol/L vs. 51.2 ± 21.0 nmol/L; p < 0.001). A higher age and lower baseline total testosterone and AMH levels were predictive of an AMH decline (p < 0.05).

Conclusion
Two cycles of CC-stimulation that did not lead to a pregnancy were accompanied by mean LH, AMH, and LH:FSH ratio declines and an SHBG increase. The clinical significance seems of minor relevance.
The role of the season at admission in neonatal sepsis: a retrospective chart review of a 1-year data at University of Gondar comprehensive specialized hospital
Authors: Gudayu Temesgen Worku , Zeleke Ejigu Gebeye , Lakew Ayenew Molla 
Published: October 2019

Abstract

Objective
Neonatal sepsis is a global public health concern in general and causes a massive burden in developing countries particularly in sub-Saharan Africa. Though it is mostly preventable, neonatal sepsis remained the leading cause of mortality in developing countries. This study was conducted to determine the current proportion and identify factors associated with neonatal sepsis to suggest directions.

Results
In this study 504 randomly selected neonatal charts were reviewed. The proportion of overall neonatal sepsis was 63.69% (95% CI 59.38, 67.79), where early-onset sepsis was 59.33% (95% CI 54.96, 63.55) and late-onset sepsis was 4.17% (95% CI 2.73, 6.31). Maternal intra-partum fever, season of birth and admission, vaginal mode of delivery and preterm gestational age at birth increased the likelihood of overall and early-onset neonatal sepsis. In conclusion of this study, neonatal sepsis remaining the leading cause of morbidity among younger infants. Intra-partum conditions were major contributors to neonatal sepsis. Thus, providing emphasis on associated factors in particular and universal safe obstetric care in general is recommended.
Detection of extended-spectrum beta-lactamase-producing E. coli and Klebsiella spp. in effluents of different hospitals sewage in Biratnagar, Nepal
Authors: Mahato Sanjay , Mahato Ajay , Pokharel Elina , Tamrakar Ankita 
Published: October 2019

Abstract

Objective
This study was aimed to determine prevalence and resistance pattern like multidrug resistant (MDR) or ESBL nature of E. coli and Klebsiella spp. from various sewage drain samples with an idea to deliver baseline information that could be utilized for defining guidelines for the treatment of hospital sewages.

Results
Of 10 sewage samples analyzed, 7 (70%) contained E. coli while 6 (60%) contained Klebsiella. Except one sample, all positive samples contained both E. coli and Klebsiella spp. E. coli isolates were resistant to ampicillin, amoxicillin, cefoxitin, cefuroxime, and cefpodoxime; while 85.7% were resistant to amoxicillin/clavulanate, ceftazidime, cefotaxime and ceftriaxone. 71.4%, 57.1%, 42.9%, and 28.6% were resistant to aztreonam, trimethoprim/sulfamethoxazole, nitrofurantoin, and gentamicin. Most were sensitive to chloramphenicol, ofloxacin, ciprofloxacin, and azithromycin. 85.7% and 57.1% of E. coli were MDR and ESBL isolates, respectively. Klebsiella were resistant to ampicillin, amoxicillin, and amoxicillin/clavulanate. 83.4% of Klebsiella were resistant to cefoxitin. 66.7% of strains were resistant to cefuroxime, ceftazidime, cefotaxime, ceftriaxone, and cefpodoxime. Klebsiella showed 50% resistant to aztreonam and trimethoprim/sulfamethoxazole, while 33.3% were resistant to chloramphenicol, nitrofurantoin, ofloxacin, and ciprofloxacin. Klebsiella were sensitive to azithromycin and gentamicin. 66.7% and 33.3% of Klebsiella were MDR and ESBL isolates, respectively.