bluuebunny/crossref_metadata_2025_split huggingface dataset:
An investigation into the noradrenergic and serotonergic contributions of diffuse noxious inhibitory controls in a monoiodoacetate model of osteoarthritis
Authors: Lockwood S. M. , Bannister K. , Dickenson A. H. 
Published: November 2018

Osteoarthritis (OA) is a debilitating conditioning with pain as the major clinical symptom. Understanding the mechanisms that drive OA-associated chronic pain is crucial for developing the most effective analgesics. Although the degradation of the joint is the initial trigger for the development of chronic pain, the discordance between radiographic joint damage and the reported pain experience in patients, coupled with clinical features that cannot be explained by purely peripheral mechanisms, suggest there are often other factors at play. Therefore, this study considers the central contributions of chronic pain, using a monoiodoacetate (MIA) model of OA. Particularly, this study explores the functionality of descending controls over the course of the model by assessing diffuse noxious inhibitory controls (DNIC). Early-phase MIA animals have a functional DNIC system, whereas DNIC are abolished in late-phase MIA animals, indicating a dysregulation in descending modulation over the course of the model. In early-phase animals, blocking the actions of spinal α2-adrenergic receptors completely abolishes DNIC, whereas blocking the actions of spinal 5-HT7 receptors only partially decreases the magnitude of DNIC. However, activating the spinal α2-adrenergic or 5-HT7 receptors in late-phase MIA animals restored DNIC-induced neuronal inhibition. This study confirms that descending noradrenergic signaling is crucial for DNIC expression. Furthermore, we suggest a compensatory increase in descending serotonergic inhibition acting at 5-HT7 receptors as the model progresses such that receptor activation is sufficient to override the imbalance in descending controls and mediate neuronal inhibition. NEW & NOTEWORTHY This study showed that there are both noradrenergic and serotonergic components contributing to the expression of diffuse noxious inhibitory controls (DNIC). Furthermore, although a tonic descending noradrenergic tone is always crucial for the expression of DNIC, variations in descending serotonergic signaling over the course of the model mean this component plays a more vital role in states of sensitization.
Response properties of single neurons in higher level auditory cortex of adult songbirds
Authors: Bottjer Sarah W. , Ronald Andrew A. , Kaye Tiara 
Published: November 2018

The caudomedial nidopallium (NCM) is a higher level region of auditory cortex in songbirds that has been implicated in encoding learned vocalizations and mediating perception of complex sounds. We made cell-attached recordings in awake adult male zebra finches ( Taeniopygia guttata) to characterize responses of single NCM neurons to playback of tones and songs. Neurons fell into two broad classes: narrow fast-spiking cells and broad sparsely firing cells. Virtually all narrow-spiking cells responded to playback of pure tones, compared with approximately half of broad-spiking cells. In addition, narrow-spiking cells tended to have lower thresholds and faster, less variable spike onset latencies than did broad-spiking cells, as well as higher firing rates. Tonal responses of narrow-spiking cells also showed broader ranges for both frequency and amplitude compared with broad-spiking neurons and were more apt to have V-shaped tuning curves compared with broad-spiking neurons, which tended to have complex (discontinuous), columnar, or O-shaped frequency response areas. In response to playback of conspecific songs, narrow-spiking neurons showed high firing rates and low levels of selectivity whereas broad-spiking neurons responded sparsely and selectively. Broad-spiking neurons in which tones failed to evoke a response showed greater song selectivity compared with those with a clear tuning curve. These results are consistent with the idea that narrow-spiking neurons represent putative fast-spiking interneurons, which may provide a source of intrinsic inhibition that contributes to the more selective tuning in broad-spiking cells. NEW & NOTEWORTHY The response properties of neurons in higher level regions of auditory cortex in songbirds are of fundamental interest because processing in such regions is essential for vocal learning and plasticity and for auditory perception of complex sounds. Within a region of secondary auditory cortex, neurons with narrow spikes exhibited high firing rates to playback of both tones and multiple conspecific songs, whereas broad-spiking neurons responded sparsely and selectively to both tones and songs.
GALAD Score for Hepatocellular Carcinoma Detection in Comparison with Liver Ultrasound and Proposal of GALADUS Score
Authors: Yang Ju Dong , Addissie Benyam D. , Mara Kristin C. , Harmsen William S. , Dai Jianliang , Zhang Ning , Wongjarupong Nicha , Ali Hawa M. , Ali Hamdi A. , Hassan Fatima A. , Lavu Sravanthi , Cvinar Jessica L. , Giama Nasra H. , Moser Catherine D. , Miyabe Katsuyuki , Allotey Loretta K. , Algeciras-Schimnich Alicia , Theobald J. Paul , Ward Melissa M. , Nguyen Mindie H. , Befeler Alex S. , Reddy K. Rajender , Schwartz Myron , Harnois Denise M. , Yamada Hiroyuki , Srivastava Sudhir , Rinaudo Jo Ann , Gores Gregory J. , Feng Ziding , Marrero Jorge A. , Roberts Lewis R. 
Published: November 2018

Abstract

Background:
The GALAD score is a serum biomarker–based model that predicts the probability of having hepatocellular carcinoma (HCC) in patients with chronic liver disease. We aimed to assess the performance of the GALAD score in comparison with liver ultrasound for detection of HCC.

Methods:
A single-center cohort of 111 HCC patients and 180 controls with cirrhosis or chronic hepatitis B and a multicenter cohort of 233 early HCC and 412 cirrhosis patients from the Early Detection Research Network (EDRN) phase II HCC Study were analyzed.

Results:
The area under the ROC curve (AUC) of the GALAD score for HCC detection was 0.95 [95% confidence interval (CI), 0.93–97], which was higher than the AUC of ultrasound (0.82, P &lt;0.01). At a cutoff of −0.76, the GALAD score had a sensitivity of 91% and a specificity of 85% for HCC detection. The AUC of the GALAD score for early-stage HCC detection remained high at 0.92 (95% CI, 0.88–0.96; cutoff −1.18, sensitivity 92%, specificity 79%). The AUC of the GALAD score for HCC detection was 0.88 (95% CI, 0.85–0.91) in the EDRN cohort. The combination of GALAD and ultrasound (GALADUS score) further improved the performance of the GALAD score in the single-center cohort, achieving an AUC of 0.98 (95% CI, 0.96–0.99; cutoff −0.18, sensitivity 95%, specificity 91%).

Conclusions:
The performance of the GALAD score was superior to ultrasound for HCC detection. The GALADUS score further enhanced the performance of the GALAD score.

Impact:
The GALAD score was validated in the United States.
Physical Activity, Physical Function, and Quadriceps Muscle Thickness in Male Patients with Sub-Acute Stroke during Hospitalization: A Pilot Study
Authors: Nozoe Masafumi , Kubo Hiroki , Furuichi Asami , Kanai Masashi , Yamamoto Miho , Kobayashi Miki , Shimada Shinichi , Mase Kyoshi 
Published: November 2018

Increasing physical activity (PA) is an important rehabilitation target for patients with sub-acute stroke during hospitalization in order to recover physical function and prevent stroke recurrence. However, the characteristics of low PA in stroke patients during hospitalization who were targets for increased intervention have not been reported. The purpose of this study was to investigate the relationship between the daily number of steps and physical function and quadriceps muscle thickness (QMT) in patients with sub-acute stroke during hospitalization for convalescence rehabilitation. Twenty-nine patients with ischemic or haemorrhagic stroke (mean age, 69 ± 11 years) hospitalized for inpatient convalescent rehabilitation were included. PA was measured using a three-dimensional accelerometer that calculates the daily number of steps taken. Physical function was measured by a short physical performance battery (SPPB; 0–12 points) and the leg motor selectivity score (6 motor stages defined by Brunnstrom), and the QMT of both legs was measured using ultrasonography. PA was significantly correlated with the SPPB score (<i>r</i> = 0.63, <i>p</i> = 0.0002), QMT on the paretic side (<i>r</i> = 0.41, <i>p</i> = 0.02), and QMT on non-paretic side (<i>r</i> = 0.56, <i>p</i> = 0.002). There were no significant effects of the leg motor selectivity score on daily PA (<i>F</i> = 1.37, <i>p</i> = 0.27). In the multiple regression analysis, only the SPPB score showed significant linear regression (β = 0.44, <i>p</i> = 0.02). PA in male patients with sub-acute stroke during hospitalization was related to physical function and QMT and not with the severity of paresis.
Saltzman’s Model. Part I: Complete Characterization of Solution Properties
Authors: Lakshmivarahan S. , Lewis John M. , Hu Junjun 
Published: November 2018

AbstractIn Saltzman’s seminal paper from 1962, the author developed a framework based on the spectral method for the analysis of the solution to the classical Rayleigh–Bénard convection problem using low-order models (LOMs), LOM (n) with n ≤ 52. By way of illustrating the power of these models, he singled out an LOM (7) and presented a very preliminary account of its numerical solution starting from one initial condition and for two values of the Rayleigh number, λ = 2 and 5. This paper provides a complete mathematical characterization of the solution of this LOM (7), herein called the Saltzman LOM (7) [S-LOM (7)]. Historically, Saltzman’s examination of the numerical solution of this low-order model contained two salient characteristics: 1) the periodic solution (in the physical 3D space and time) that expand on Rayleigh’s classical study and 2) a nonperiodic solution (in the temporal space dealing with the evolution of Fourier amplitude) that served Lorenz in his fundamental study of chaos in the early 1960s. Interestingly, the presence of this nonperiodic solution was left unmentioned in Saltzman’s study in 1962 but explained in detail in Lorenz’s scientific biography in 1993. Both of these fundamental aspects of Saltzman’s study are fully explored in this paper and bring a sense of completeness to the work.
Tropopause Evolution in a Rapidly Intensifying Tropical Cyclone: A Static Stability Budget Analysis in an Idealized Axisymmetric Framework
Authors: Duran Patrick , Molinari John 
Published: November 2018

Abstract
Upper-level static stability (N2) variations can influence the evolution of the transverse circulation and potential vorticity in intensifying tropical cyclones (TCs). This paper examines these variations during the rapid intensification (RI) of a simulated TC. Over the eye, N2 near the tropopause decreases and the cold-point tropopause rises by up to 4 km at the storm center. Outside of the eye, N2 increases considerably just above the cold-point tropopause and the tropopause remains near its initial level. A budget analysis reveals that the advection terms, which include differential advection of potential temperature θ and direct advection of N2, are important throughout the upper troposphere and lower stratosphere. These terms are particularly pronounced within the eye, where they destabilize the layer near and above the cold-point tropopause. Outside of the eye, a radial–vertical circulation develops during RI, with strong outflow below the tropopause and weak inflow above. Differential advection of θ near the outflow jet provides forcing for stabilization below the outflow maximum and destabilization above. Turbulence induced by vertical wind shear on the flanks of the outflow maximum also modifies the vertical stability profile. Meanwhile, radiative cooling tendencies at the top of the cirrus canopy generally act to destabilize the upper troposphere and stabilize the lower stratosphere. The results suggest that turbulence and radiation, alongside differential advection, play fundamental roles in the upper-level N2 evolution of TCs. These N2 tendencies could have implications for both the TC diurnal cycle and the tropopause-layer potential vorticity evolution in TCs.
New Statistical Methods for Precipitation Bias Correction Applied to WRF Model Simulations in the Antisana Region, Ecuador
Authors: Heredia María Belén , Junquas Clémentine , Prieur Clémentine , Condom Thomas 
Published: November 2018

Abstract
The Ecuadorian Andes are characterized by a complex spatiotemporal variability of precipitation. Global circulation models do not have sufficient horizontal resolution to realistically simulate the complex Andean climate and in situ meteorological data are sparse; thus, a high-resolution gridded precipitation product is needed for hydrological purposes. The region of interest is situated in the center of Ecuador and covers three climatic influences: the Amazon basin, the Andes, and the Pacific coast. Therefore, regional climate models are essential tools to simulate the local climate with high spatiotemporal resolution; this study is based on simulations from the Weather Research and Forecasting (WRF) Model. The WRF Model is able to reproduce a realistic precipitation variability in terms of the diurnal cycle and seasonal cycle compared to observations and satellite products; however, it generated some nonnegligible bias in the region of interest. We propose two new methods for precipitation bias correction of the WRF precipitation simulations based on in situ observations. One method consists of modeling the precipitation bias with a Gaussian process metamodel. The other method is a spatial adaptation of the cumulative distribution function transform approach, called CDF-t, based on Voronoï diagrams. The methods are compared in terms of precipitation occurrence and intensity criteria using a cross-validation leave-one-out framework. In terms of both criteria, the Gaussian process metamodel approach yields better results. However, in the upper parts of the Andes (&gt;2000 m), the spatial CDF-t method seems to better preserve the spatial WRF physical patterns.
Spread and Skill in Mixed- and Single-Physics Convection-Allowing Ensembles
Authors: Loken Eric D. , Clark Adam J. , Xue Ming , Kong Fanyou 
Published: November 2018

Abstract
Spread and skill of mixed- and single-physics convection-allowing ensemble forecasts that share the same set of perturbed initial and lateral boundary conditions are investigated at a variety of spatial scales. Forecast spread is assessed for 2-m temperature, 2-m dewpoint, 500-hPa geopotential height, and hourly accumulated precipitation both before and after a bias-correction procedure is applied. Time series indicate that the mixed-physics ensemble forecasts generally have greater variance than comparable single-physics forecasts. While the differences tend to be small, they are greatest at the smallest spatial scales and when the ensembles are not calibrated for bias. Although differences between the mixed- and single-physics ensemble variances are smaller for the larger spatial scales, variance ratios suggest that the mixed-physics ensemble generates more spread relative to the single-physics ensemble at larger spatial scales. Forecast skill is evaluated for 2-m temperature, dewpoint temperature, and bias-corrected 6-h accumulated precipitation. The mixed-physics ensemble generally has lower 2-m temperature and dewpoint root-mean-square error (RMSE) compared to the single-physics ensemble. However, little difference in skill or reliability is found between the mixed- and single-physics bias-corrected precipitation forecasts. Overall, given that mixed- and single-physics ensembles have similar spread and skill, developers may prefer to implement single- as opposed to mixed-physics convection-allowing ensembles in future operational systems, while accounting for model error using stochastic methods.
Three types of biconjugate residual method for general periodic matrix equations over generalized bisymmetric periodic matrices
Authors: Hajarian Masoud 
Published: November 2018

As is well known, periodic matrix equations have wide applications in many areas of control and system theory. This paper is devoted to a study of the numerical solutions of a general type of periodic matrix equations. We present three types of biconjugate residual (BCR) method to find the generalized bisymmetric periodic solutions [Formula: see text] of general periodic matrix equations [Formula: see text] The main theorems of this paper show that the presented methods can compute the generalized bisymmetric periodic solutions in a finite number of steps in the absence of round-off errors. We give two numerical examples to illustrate and interpret the theoretical results.
Effectiveness of rehabilitation after cervical disk surgery: a systematic review of controlled studies
Authors: Tederko Piotr , Krasuski Marek , Tarnacka Beata 
Published: November 2018

Objectives: To present a synopsis of evidence on the efficacy of rehabilitation after cervical disk surgery performed for neck pain and radiculopathy. Data sources: The databases of Medline, EMBASE, and Cochrane Central were searched for studies reporting effects of rehabilitation interventions in patients undergoing surgery due to cervical disk disease with pain and radicular syndrome, published before 31 August 2018. Review methods: Project was registered with PROSPERO database (number CRD42018085937). Randomized controlled trials that evaluated the efficacy of rehabilitation interventions versus other, sham, or no treatment were selected. The primary outcomes were disability and pain. Secondary outcomes were other measures assessing biological, psychological or social effect of rehabilitation. Two reviewers independently screened studies for eligibility, assessed risk of bias and extracted data. Evaluation of evidence was performed with the GRADE system. Results: Five papers were included in the review. The eligible studies were heterogeneous in intervention and outcome reporting. There are low- to very-low-quality evidence that some interventions (use of cervical collars after non-plated anterior cervical diskectomy an fusion, structured physiotherapy, and interactive patients’ education) provide some benefit within functioning, pain, and selected psychological variables in patients undergoing cervical disk surgery. Controlled trials addressing comprehensive interdisciplinary rehabilitation, multidisciplinary pain management, occupational therapy, psychotherapy, social and vocational interventions were not identified. Conclusion: There is insufficient evidence with few trials of low quality to allow any conclusion to be drawn about the effectiveness, harms, and general ineffectiveness of rehabilitation for people who have had cervical disk surgery for pain or radiculopathy.
The effect of early intervention of mirror visual feedback on pain, disability and motor function following hand reconstructive surgery: a randomized clinical trial
Authors: Abolfazli Mahsa , Lajevardi Laleh , Mirzaei Leila , Abdorazaghi Hosein Ali , Azad Akram , Taghizadeh Ghorban 
Published: November 2018

Objective: To determine the effect of mirror visual feedback (MVF) on disability, pain, and motor function on patients who underwent hand reconstructive surgery. Design: Randomized, single-blinded controlled trial. Setting: Rehabilitation center. Subjects: A total of 40 patients who were randomly assigned into the intervention group ( n = 20) and control group ( n = 20) participated in this study. Interventions: The rehabilitation sessions took place twice a week for eight weeks. The control group received traditional rehabilitation for 75 minutes. While the intervention group performed MVF and traditional rehabilitation for 30 and 45 minutes, respectively. Measures: Pain and disability of the hand were assessed with McGill pain questionnaire and Disability of Arm, Shoulder, and Hand (DASH) scores. The range of joint motion was evaluated by Goniometer, and the strength of grip and pinch was evaluated by Dynamometer and Pinch gauge and dexterity evaluated by Minnesota Manual Muscle test. Results: The results indicated that both traditional and MVF methods induced significant decreasing pain (Pain Rate Index: F = 68.48, P = 0.000; Number of Word Count: F = 70.96, P = 0.000), disability ( F = 50.08, P = 0.000) and increasing dexterity (placing test: F = 28.73, P = 0.000), and range of motion ( F = 33.16, P = 0.000). The results also showed that the positive effect of MVF on pain, disability, dexterity, and range of motion was significantly greater than that of controls ( P < 0.05), but there was no significant result in grip and lateral pinch strength between the intervention and control group ( P > 0.05). Conclusion: MVF, in conjunction with traditional rehabilitation programs, may lead to greater improvements in pain, disability, placing dexterity, and range of motion. But it seems not to be effective on pinch and grip power and turning dexterity.
Sociodemographic, Anthropometric, and Dietary Predictors of Polyunsaturated Fatty Acids in Adipose Tissue Among Mesoamerican Children and Their Parents
Authors: Flannagan Kerry S. , Ramirez-Zea Manuel , Roman Ana Victoria , Das Arun K. , Villamor Eduardo 
Published: November 2018

Background: Polyunsaturated fatty acid (PUFA) intake is low throughout Latin America. Improving PUFA status could be an effective intervention against chronic disease, but information on sociodemographic and dietary patterning of PUFA status in the region is limited. Objective: To characterize sociodemographic, anthropometric, and dietary predictors of PUFA status biomarkers in adipose tissue among children and their parents from Mesoamerica. Methods: This was a cross-sectional study of 220 children aged 7 to 12 years and 471 parents from capital cities of Guatemala, El Salvador, the Dominican Republic, Honduras, Nicaragua, Panama, Costa Rica, and Belize, as well as Tuxtla Gutiérrez in Mexico. The PUFA from gluteal adipose tissue was quantified using gas chromatography. Participants reported sociodemographic information and the type of vegetable oil used for cooking. We estimated percent mean differences in linoleic acid (LA), total long-chain n-6 PUFA (n-6 LCPUFA), α-linolenic acid (ALA), and total long-chain n-3 PUFA (n-3 LCPUFA) between levels of predictors using multivariable-adjusted linear regression models. Results: Country was the strongest predictor of any PUFA, whereas body mass index was positively associated with n-6 LCPUFA in children and adults. Cooking primarily with soybean oil was positively associated with LA in children and adults and ALA in adults. Cooking with canola oil was positively related to n-6 LCPUFA in adults and n-3 LCPUFA in children and adults. Cooking with palm oil was associated with low adipose tissue levels of all n-6 and n-3 PUFA. Conclusions: Adipose tissue PUFA status in Mesoamerica is associated with country of origin and the type of oil used for cooking.