bluuebunny/crossref_metadata_2025_split huggingface dataset:
Long non-coding RNA TUSC7 suppresses osteosarcoma by targeting miR-211
Authors: Cong Menglin , Jing Rui 
Published: October 2019

Abstract
Long non-coding RNAs (lncRNAs) play a critical role in regulating cancer progression and metastasis. LncRNA tumor suppressor candidate 7 (TUSC-7) was shown to be a tumor suppressor in osteosarcoma. However, the regulation mechanism of TUSC-7 in osteosarcoma is unknown. Bioinformatics analysis showed that TUSC7 specifically binds to miR-211. MiR-211 was up-regulated in osteosarcoma and negatively correlated with the expression of TUSC7. miR-211 expression was inhibited remarkably by TUSC7 overexpression and the reciprocal inhibition exists between TUSC7 and miR-211. RNA pull-down and luciferase reporter assays were used to validate the sequence-specific correlation between miR-211 and TUSC7. TUSC7 inhibited the proliferation, migration of osteosarcoma cells and promoted cellular apoptosis, which is largely mediated by miR-211. We conclude that the TUSC7 acted as a tumor suppressor gene, which is negatively regulated by miR-211. Our study could suggest a potentially novel therapeutic strategy against osteosarcoma.
Research-Based Updates in Swallowing and Communication Dysfunction in Parkinson Disease: Implications for Evaluation and Management
Authors: Broadfoot C. K. , Abur D. , Hoffmeister J. D. , Stepp C. E. , Ciucci M. R. 
Published: October 2019

Purpose
Individuals with Parkinson disease (PD) present with complex and variable symptoms, with recent findings suggesting that the etiology of PD extends beyond the involvement of just the basal ganglia. These symptoms include significant impairments in the speech and swallowing domains, which can greatly affect quality of life and therefore require therapeutic attention. This research-based update reviews the neurophysiological basis for swallowing and speech changes in PD, the effectiveness of various types of treatments, and the implications for symptom evaluation and management.

Conclusion
The mechanisms responsible for swallowing and speech symptoms in PD remain largely unknown. Dopaminergic medication and deep brain stimulation do not provide consistent benefits for these symptoms, suggesting a nondopaminergic network is involved. Importantly, evidence suggests that symptoms of dysphagia and hypokinetic dysarthria may be early indications of PD, so it is critical to investigate the cause of these changes.
Biosynthesis of antibacterial silver nanoparticles using Astragalus verus Olivier
Authors: Askari Zahra , Vahabi Mohammad Reza , Allafchian Alireza , Mousavi Seyed Alireza , Jalali Seyed Amir Hossein 
Published: October 2019

In this work, a green method was introduced for preparing silver nanoparticles (Ag NPs) using gum tragacanth extracted from Astragalus verus Olivier. The absence of a chemical reducing agent that may be toxic is an advantage of this method. The Ag NPs were prepared in different tragacanth concentrations, pH values, and temperatures. XRD, FT‐IR, and UV–vis spectroscopy analyses confirmed the structure of the synthesised Ag NPs. TEM and FESEM images showed that the prepared Ag NPs have spherical shapes. The FESEM images determined that a pH of 10 and a synthesis temperature of 50°C would be the optimal condition for preparing Ag NPs in this method. The change in concentration of tragacanth does not have much effect on the quality of Ag NPs. Obtained data from DLS revealed that the average diameter of Ag NPs is about 40 nm. The antibacterial activity of the prepared nanoparticles was evaluated against both Gram‐positive and Gram‐negative bacterial species. The results of the antibacterial tests showed that the prepared Ag NPs possess a desirable antibacterial activity.
On the integrable deformations of a system related to the motion of two vortices in an ideal incompressible fluid
Authors: Lăzureanu Cristian , Hedrea Ciprian , Petrişor Camelia 
Published: October 2019

Altering the first integrals of an integrable system integrable deformations of the given system are obtained. These integrable deformations are also integrable systems, and they generalize the initial system. In this paper we give a method to construct integrable deformations of maximally superintegrable Hamiltonian mechanical systems with two degrees of freedom.
An integrable deformation of a maximally superintegrable Hamiltonian mechanical system preserves the number of first integrals, but is not a Hamiltonian mechanical system, generally. We construct integrable deformations of the maximally superintegrable Hamiltonian mechanical system that describes the motion of two vortices in an ideal incompressible fluid, and we show that some of these integrable deformations are Hamiltonian mechanical systems too.
Fate Tracing of Isl1+Cells in Adult Mouse Hearts under Physiological and Exercise Conditions
Authors: Zhou Yunhe , Yang Hua , Shi Jiahao , Zhang Mengjie , Yang Sai , Wang Ning , Sun Ruilin , Wang Zhugang , Fei Jian 
Published: October 2019

AbstractMyocardial damage due to dysfunctional myocardium has been increasing, and the prognosis of pharmacological and device-based therapies remain poor. Isl1-expressing cells were thought to be progenitor cells for cardiomyocyte proliferation after specific stimuli. However, the true origin of the proliferating myocardiac cells and the role of Isl1 in adult mammals remain unresolved. In this study, Isl1-CreERT2 knock-in mouse model was constructed using CRISPR/Cas9 technology. Using tamoxifen-inducible Isl1-CreERT/Rosa26R-LacZ system, Isl1+cells and their progeny were permanently marked by lacZ-expression. X-gal staining, immunostaining, and quantitative PCR were then used to reveal the fate of Isl1+cells under physiological and exercise conditions in mouse hearts from embryonic stage to adulthood. Isl1+cells were found to localize to the sinoatrial node, atrioventricular node, cardiac ganglia, aortic arch, and pulmonary roots in adult mice heart. However, they did not act as cardiac progenitor cells under physiological and exercise conditions. Although Isl1+cells showed progenitor cell properties in early mouse embryos (E7.5), this ability was lost by E9.5. Furthermore, although the proliferation and regeneration of heart cell was observed in response to exercise, the cells associated were not Isl1 positive.
Rheumatoide Arthritis aus der Perspektive der Āyurveda-Medizin – Diagnose und Therapie
Authors: Chopra Ananda Samir 
Published: October 2019

ZusammenfassungDas modern definierte Krankheitsbild der rheumatoiden Arthritis wird im Āyurveda meist mit der klassischen Krankheitskategorie Āmavāta identifiziert. Bei dieser Erkrankung bewirken die Ansammlung „unverdauter Stoffwechselprodukte“ (Āma) und die gleichzeitige Aggravation des Doșa Vāta Gelenkentzündungen und verschiedene andere Symptome. Auf der Grundlage einer genauen Diagnose der Erkrankung und des Patienten erfolgen individuelle Empfehlungen zu Ernährung und Lebensweise. Eine vielfältige Phytotherapie und auch der Einsatz intensiver Therapieverfahren, welche ausleitende und krankheitsbehandelnde Anwendungen enthalten, ergänzen das umfassende therapeutische Spektrum der Āyurveda-Medizin. Heutzutage wird die Wirksamkeit vieler āyurvedischer Therapieansätze auch nach modernen Kriterien untersucht. Probleme und Perspektiven solcher Studien werden ebenfalls kurz diskutiert.
Entwicklung einer Schulung zur Förderung der Gesundheitskompetenz von Patienten mit variablem Immundefekt (CVID)
Authors: Bayrhuber Marianne , Tinsel Iris , Goldacker Sigune , Farin Erik , Warnatz Klaus , Nieters Alexandra 
Published: October 2019

Zusammenfassung
Ziel der Studie Ziel ist es, die Entwicklung einer Schulung zur Förderung der Gesundheitskompetenz von Patienten mit einem Immundefekt und die Ergebnisse zur Zufriedenheit und Akzeptanz darzustellen.
Methodik Der Bedarf der Patienten an einer Schulung wurde mit einem Fragebogen ermittelt (N=238), zusätzlich wurden Interviews mit ärztlichen Immunologen (N=5) und Personen mit variablem Immundefekt CVID (N=9) geführt. Auf dieser Basis wurde ein Manual für die Schulung erstellt, welches (1) die aktive Kommunikation mit Behandlern sowie (2) die gesundheitsbezogene Kommunikation am Arbeitsplatz beinhaltet. Die Beurteilung der Zufriedenheit der Teilnehmenden (N=49) mit der Intervention erfolgte anhand eines Fragebogens.
Ergebnisse Die Bewertungen der Schulung aus Sicht der Patienten liegen im guten bis sehr guten Bereich (M=1,77; SD=0,38). Aus der Analyse der Freitexte konnten hilfreiche Hinweise für die Verbesserung der Schulung abgeleitet werden.
Schlussfolgerung Die Ergebnisse der Evaluation der Patientenschulung zeigen, dass die neue Schulung akzeptiert wird und von den Patienten als verständlich und relevant eingeschätzt wird.
Infectious Aortic Root Pseudoaneurysm after Bentall Procedure: To Treat or Not to Treat by Redo Operation?
Authors: Saitto Guglielmo , Russo Marco , Pugliese Marta , Vacirca Sara R. , Bertoldo Fabio , Nardi Paolo , Ruvolo Giovanni 
Published: October 2019

AbstractWe present a case of a 75-year-old man who developed an early aortic bioprosthesis endocarditis due to Klebsiella pneumoniae complicated by aortic root pseudoaneurysm after Bentall procedure. A prompt surgical option was hypothesized, but we decided to wait and keep on clinical observation and antibiotic therapy. One year after discharge, we observed stable clinical conditions and echocardiographic findings. A question: to treat or not to treat by redo operation an infectious aortic root pseudoaneurysm?
Spectrum of Cardiovascular Abnormalities in Infants Born to Diabetic Mother in a Tertiary Care Center
Authors: Arul A. S. , Babu Kandha Kumar A. S. , Kiruthiga K. , Priya M. Kanaga , Neveythaa S. A. 
Published: October 2019

Abstract
Background Diabetes mellitus is one of the most common medical problems among pregnant women. Now, gestational diabetes mellitus (GDM) is increasing and amounts to 17% in Asian women but only in 4% of American and European women. In southern India, the prevalence of GDM is 17% in urban women, 13.8% in semiurban, and 9.8% in rural women.
Aim The aim of the study is to find the cardiovascular abnormalities in infants born to a diabetic mother (IDM) and the association between infant’s heart lesion and diabetes mellitus in pregnant mother in a tertiary care center.
Materials and Methods All babies born to both pregestational and gestational diabetic mother were included. Information regarding maternal type of diabetes, treatment regimen, maternal glycemic control status, antenatal ultrasonogram, baby’s sex, birth weight, gestational age, and clinical features were collected. Echocardiogram was done for all the babies.
Results Out of the 100 IDM, 28 babies had cardiac disease, 5 babies had cyanotic heart disease, and 23 babies had acyanotic heart disease. Out of 100 diabetic mothers, 66 were on meal plan, 21 were on oral hypoglycemic agent (OHA) metformin, and 13 were on insulin therapy. Among 66 babies whose mother was on the meal plan, 8 had cardiac abnormality. Among the 21 mothers on OHA, 7 babies had cardiac abnormality and all the 13 babies of mothers who were on insulin had cardiac abnormality which was a significant finding among the IDM.
Conclusion Maternal diabetes is a significant risk factor for heart disease in the newborn. Careful evaluation and early diagnosis of heart diseases in this high-risk group is of great value. Both pregestational and gestational diabetic mothers should monitor their blood sugar and maintain it in a normal range at the time of conception and early in pregnancy to reduce the risk of congenital heart disease in IDM.
Styloid Process Elongation or Eagle’s Syndrome: Is There Any Role for Ectopic Calcification?
Authors: Gokce Cumali , Sisman Yildiray , Sipahioglu Murat 
Published: October 2019

ABSTRACTDue to the angulation of maxillary bone as the maxillary bone resorption occurs from a buccal to
palatal direction, bucco-lingually tilted implant placement is more likely especially in the posterior maxilla. The aim of this paper was to present a case restored by using a maxillary hybrid denture using Cresco method. A 59-year-old woman with an edentulous maxilla and five missing mandibular teeth was referred for implant treatment. Six months after sinus lift operation, four mandibular implants and six maxillary implants were placed. Due to the bucco-lingual tilt of two implants, the Cresco method was chosen to fabricate the metal framework for the maxillary hybrid denture that was delivered four months after implant placement. The main advantages of the Cresco method are a perfectly passive framework fit and corrected screw access holes. All ten implants placed were considered successful at 1-year recall, and no screw access holes were seen in the buccal part of the maxillary acrylic teeth.It was concluded that such screw-retained maxillary hybrid denture using the Cresco method met the esthetic expectations of a highly demanding patient. (Eur J Dent 2008;2:220-223)
Effect of Storage Temperature on Bond Strength of a Self-Etch Adhesive System to Pulp Chamber Dentin
Authors: Donmez Nazmiye , Ari Hale , Belli Sema 
Published: October 2019

ABSTRACTObjectives: The aim of this study was to evaluate the effect of storage temperature on bond
strength of a self etching primer system to pulp chamber dentin.Methods: SE Bond (Kuraray, JAPAN) adhesive system and Clearfil Photo Posterior (Kuraray, JAPAN) composite resin were used. Eight extracted caries-free human molar teeth were used. Access cavities were prepared through the pulp chamber, randomly distributed into 4 groups and prepared as follows: Group 1 (Control): SE Primer and SE Bond (SEB) were applied to the pulp chamber dentin according to the manufacturer’s instructions, immediately after the delivery from the manufacturer and then the pulp chamber was restored with a resin restorative material. The primer agent of the following groups was stored in a refrigerator and kept at 4�C. Group 2: restored with SEB, kept at 4°C refrigerator for 1 year, Group 3: restored with SEB kept at 23°C room temperature for 1 year and Group 4: restored with SEB kept at 40°C incubator for 1 year. After 24 hrs the teeth were trimmed for microtensile bond testing and loaded to failure at 1mm/min. Data were analyzed using one-way ANOVA and Duncan test (P<.05).Results: The results indicated that Group 4 showed lowest bond strength when compared to the others (P<.05). No statistically significant difference was found among the other groups (P>.05).Conclusions: As a result of this study, it was concluded that increasing storing temperature or storing period decreases microtensile bond strength of a SEB system to pulp chamber dentin. (Eur J Dent 2009;3:314-317)
Inducible Nitric Oxide Expression Correlates with the Level of Inflammation in Periapical Cysts
Authors: Matsumoto Mariza Akemi , Ribeirob Daniel Araki 
Published: October 2019

ABSTRACTObjectives: In an attempt to elucidate if inducible nitric oxide expression (iNOS) is correlated with the level of inflammation in periapical cysts with accuracy, the goal of this study was to evaluate the expression of iNOS in these ones.Methods: 30 cases were included in this study being iNOS evaluated by means of immunohistochemistry. Statistical analysis was performed by Kruskal-Wallis non-parametric test followed by the post-hoc Dunn’s test.Results: iNOS stain was detected throughout the epithelium, subepithelial fibroblasts and macrophages in all cases, indistinctly. Nevertheless, iNOS immunostaining in periapical cysts was different according to the levels of inflammation, being the strongest effect associated with intense inflammatory infiltrate.Conclusions: Taken together, our results indicate that immunoreactivity of iNOS was expressed in several cellular types present in periapical cyst, being positively correlated with the level of inflammation. Therefore, iNOS expression plays an important role in the pathogenesis of periapical cysts. (Eur J Dent 2007;1:212-215)
Bond strength of one-step self-etch adhesives and their predecessors to ground versus unground enamel
Authors: Yazici A. Ruya , Yildirim Zeren , Ertan Atila , Ozgunaltay Gül , Dayangac Berrin , Antonson Sibel A , Antonson Donald E 
Published: October 2019

ABSTRACTObjectives: The aim of this study was to compare the shear bond strength of several self-etch adhesives to their two-step predecessors to ground and unground enamel.Methods: Seventy-five extracted, non-carious human third molar teeth were selected for this study. The buccal surfaces of each tooth were mechanically ground to obtain flat enamel surfaces (ground enamel), while the lingual surfaces were left intact (unground enamel). The teeth were randomly divided into five groups according to the adhesive systems (n=15): one-step self-etch adhesive - Clearfil S3 Bond, its two-step predecessor - Clearfil SE Bond, one-step self-etch adhesive - AdheSE One, and its two-step predecessor - AdheSE, and a two-step etch-and-rinse adhesive - Adper Single Bond 2(control). After application of the adhesives to the buccal and lingual enamel surfaces of each tooth, a cylindrical capsule filled with a hybrid composite resin (TPH) was seated against the surfaces. The specimens were stored in distilled water at 37°C for 24 hours, followed by thermocycling (5°C-55°C/500 cycles). They were subjected to shear bond strength test in a universal testing machine at a crosshead speed of 1.0 mm/minute. The data were compared using a two-way ANOVA, followed by Bonferroni test at P<.05Results: All adhesives exhibited statistically similar bond strengths to ground and unground enamel except for the etch-and-rinse adhesive that showed significantly higher bond strengths than the self-etch adhesives (P<.05). No significant differences in bond strength values were observed between ground and unground enamel for any of the adhesives tested (P=.17).Conclusions:Similar bond strengths to ground and unground enamel were achieved with one-step self-etch adhesives and their predecessors. Enamel preparation did not influence the bonding performance of the adhesives tested. (Eur J Dent 2012;6:280-286)
Cone-beam computed tomography analysis of the vestibular surgical pathway to the palatine root of the maxillary first molar
Authors: Kalender Atakan , Aksoy Umut , Basmaci Fatma , Orhan Kaan , Isil Orhan Ayse 
Published: October 2019

ABSTRACTObjective: The aim of this study was to evaluate the anatomical distance between apices of the palatine root of the maxillary first molars to the buccal bone plate to identify the vestibular surgical pathway in a Turkish adult population using cone-beam computed tomography (CBCT) images.Methods: CBCT scans of 107 (48 male and 59 female) patients were retrospectively analyzed. The overall mean age was 38.6 years. The distance between the vestibular cortex and vestibular side of the palatine root was measured for 192 maxillary first molars both on axial images parallel to the palatal plane and on reformatted cross-sectional images. A Pearson’s chi square test and Mann- Whitney U-test were performed to evaluate differences among age, localization, and measurements. Differences were considered statistically significant at P<.05.Results: The mean distance between the buccal cortex and the buccal side of the palatine root of the superior first molar in both male and female patients was 10.13 and 9.70 mm, respectively. The incidence of interposition of the lateral recess of the maxillary sinus between the roots was 42.2% and 49% in men and women, respectively. Statistically significant sex-related differences were found in the vestibular surgical pathway (P<.05).Conclusions: For precise planning of endodontic surgery, it is crucial to determine the exact dimensions and location of the periapical lesion, as well as its relationship with the roots and other neighboring anatomical structures. CBCT can be a powerful tool for the evaluation of surgical cases in three dimensions with less ionizing radiation and better avoidance of complications during surgery. (Eur J Dent 2013;7:35-40)
Treponema diversity in root canals with endodontic failure
Authors: Nóbrega Leticia M. M. , Delboni Maraisa G. , Martinho Frederico C. , Zaia Alexandre A , Ferraz Caio C. R. , Gomes Brenda P. F. A. 
Published: October 2019

ABSTRACTObjective: This study sought to investigate the prevalence of eight oral Treponemas (Treponema denticola, T. amylovorum, T. maltophilum, T. medium, T. pectinovorum, T. socranskii, T. vicentii and T. lecithinolyticum) in teeth with endodontic treatment failure and periapical lesion.Methods: Samples were taken from 40 root canals presenting endodontic failure and periapical lesion. DNA extraction was performed and Nested-PCR technique was used for the detection of Treponema species using specific primers.Results: Treponemas was detected in 56.5% of the samples analyzed (22/39). Individual root canals yielded a maximum of 6 target Treponema species. T. denticola (30.8%) and T. maltophilum (30.8%) were the most frequently detected species followed by T. medium (20.5%), T. socranskii (20.5%), T. pectinovorum (17.9%) and T. vicentii (17.9%). Positive association was verified between T. denticola and T. maltophilum such as T. medium (P<.05). T. lecithinolyticum was positively associated with intraradicular post (P<.05).Conclusion: The present study revealed that a wide variety of Treponema species plays a role in persistent/secondary infection turning the root canal microbiota even more complex than previously described by endodontic literature. (Eur J Dent 2013;7:61-68)
Harmonic analysis on the rank-

value group of a two-dimensional local field
Authors: Osipov D. V. , Parshin A. N. 
Published: October 2019

Abstract
In this work we construct a harmonic analysis on free Abelian groups of rank

, namely: we construct and investigate spaces of functions and distributions, Fourier transforms and actions of discrete and extended discrete Heisenberg groups. In the case of the rank-

value group of a two-dimensional local field with finite last residue field we connect this harmonic analysis with harmonic analysis on the two-dimensional local field, where the latter harmonic analysis was constructed in earlier works by the authors.
Bibliography: 15 titles.
Wnt activator FOXB2 drives the neuroendocrine differentiation of prostate cancer
Authors: Moparthi Lavanya , Pizzolato Giulia , Koch Stefan 
Published: October 2019

SignificanceAberrant activation of the homeostatic Wnt signaling pathway is a hallmark of various types of cancer. In many cases, it is unclear how elevated Wnt levels are maintained in the absence of activating pathway mutations. Here we find that the uncharacterized transcription factor FOXB2, whose expression is usually restricted to the developing brain, is induced in aggressive prostate cancer. FOXB2 strongly activates Wnt signaling via the induction of multiple pathway agonists, particularly the neurogenic ligand WNT7B. Accordingly, our analyses suggest that FOXB2 imposes a neuronal differentiation program on prostate cancer cells, which is associated with treatment failure and poor prognosis. Thus, our work identifies FOXB2 as a tissue-specific Wnt activator that may play a role in prostate cancer progression.
Myelin sheath structure and regeneration in peripheral nerve injury repair
Authors: Liu Bin , Xin Wang , Tan Jian-Rong , Zhu Rui-Ping , Li Ting , Wang Dan , Kan Sha-Sha , Xiong Ding-Kui , Li Huan-Huan , Zhang Meng-Meng , Sun Huan-Huan , Wagstaff William , Zhou Chan , Wang Zhi-Jian , Zhang Yao-Guang , He Tong-Chuan 
Published: October 2019

Significance
Afferent and efferent nerve fibers cannot be distinguished based on the axonal diameter or the presence of the Remark bundle. The compaction of the myelin sheath involves 2 steps: 1) The distance between the 2 layers of cell membranes in the double-bilayer decreases; 2) the adjacent double-bilayers close to form MDL. The expression of MBP is positively correlated with the formation of the MDL. Anchoring of the myelin sheath by lipophilin particles might be required for the formation of a compacted myelin sheath. The abnormalities in nerve fiber structure observed in autologous nerve grafts do not appear to be related to either MBP or lipophilin, so further research is needed to determine their causes.