bluuebunny/crossref_metadata_2025_split huggingface dataset:
The ‘shark mouth’ flap approach for digital glomus tumours in 24 patients: technique and clinical outcomes
Authors: Asmar Ghada , Mati Tahar , Pop Ioana Anastasia , Falcone Marc-Olivier 
Published: August 2019

This retrospective, single-centre study was carried out on patients with digital subungual glomus tumours. We describe a subperiosteal approach with a ‘shark mouth’ flap containing the nail plate and nail bed as a single unit, providing ideal exposure and easy access to the tumour. It combines the advantages of the transungual and lateral approaches, whether the subungual tumours are located centrally, peripherally or under the germinal matrix. The ‘shark mouth’ flap approach was used by the same surgeon in 24 patients with solitary glomus tumours of the fingers. Clinical outcomes at the early postoperative phase and at the last follow-up were satisfactory. Pain relief and wound healing were quickly achieved. No complications, such as fingertip numbness or nail deformities, were observed, and there was only one recurrence. This approach is reliable, nail-sparing and less time-consuming than other techniques. Level of evidence: IV
The relationship between ABO blood group type and tumor grade, stage, recurrence and progression in transitional cell carcinoma of the bladder: A preliminary report
Authors: Tiwari Deviprasad , Garg Harshit , Nayak Brusabhanu , Singh Prabhjot , Seth Amlesh 
Published: August 2019

Objectives: ABO blood grouping is a well-proven prognostic factor in many malignancies. This study aims to study the association and impact of ABO blood group on disease recurrence and progression in bladder carcinoma. Material and methods: Patients with bladder carcinoma undergoing transurethral resection of bladder tumor (TURBT) were studied prospectively for at least 1-year follow-up for recurrence and progression of the disease. Demographic profile along with blood group was noted. Results: Two hundred patients were included in the study and 194 patients were included in the final analysis. Muscle-invasive bladder cancer was present in 39 (20.1%) patients and the high-grade tumor was present in 88 (45.3%) patients. There was no statistical significance between the association of blood grouping and grade ( p=0.29) and stage of the disease ( p=0.20). During the follow-up period, there were 100 (64.5%) recurrences and 15 (9.7%) patients with non-muscle-invasive bladder carcinoma had progression. The association of blood group with recurrence ( p=0.66) and progression ( p=0.11) of disease was not statistically significant. Conclusion: There is no association between bladder cancer and ABO blood group in terms of grade and stage of the disease. The recurrence and progression of the disease did not differ significantly in different blood groups. Level of Evidence: 2b
Posterior Ligamentous Reinforcement of the Upper Instrumented Vertebrae +1 Does Not Decrease Proximal Junctional Kyphosis in Adult Spinal Deformity
Authors: Iyer Sravisht , Lovecchio Francis , Elysée Jonathan Charles , Lafage Renaud , Steinhaus Michael , Schwab Frank J. , Lafage Virginie , Kim Han Jo 
Published: August 2019

Study Design: Retrospective cohort study. Objectives: Violation of the posterior soft tissues is believed to contribute to the development of proximal junctional kyphosis (PJK). Biomechanical and clinical studies suggest that augmentation of the posterior ligamentous structures (PLS) may help prevent PJK. The purpose of this study was to evaluate the effect of PLS augmentation on the rate of PJK at 1 year. Methods: A retrospective single-surgeon cohort study was performed of 108 adult spinal deformity patients who underwent 5 level fusions to the pelvis. Patients were divided into 2 groups: PLS+ patients had reconstruction of the PLS between upper instrumented vertebrae +1 (UIV+1) and UIV−1 with a surgical nylon tape while PLS− patients did not. Demographics, surgical data, and sagittal alignment parameters were compared between the cohorts. The primary outcome of interest was the development of PJK at final follow-up. A subgroup propensity match and logistic regression model were utilized to control for differences in the cohorts. Results: A total of 108 patients met final criteria, 31 patients (28.7%) were PLS+. There were no differences with regard to preoperative or final sagittal alignment parameters, number of levels fused, rates of 3-column osteotomies, and body mass index ( P > .05), though the PLS+ cohort was older and had larger initial sagittal corrections ( P < .05). The rates of PJK for PLS+ (27.3%) and PLS− (28.6%) were similar ( P = .827). After controlling for sagittal correction via propensity matching, PLS+ had no impact on PJK (29% vs 38.7%, P = .367). In our multivariate analysis, only increased sagittal malalignment and failure to restore sagittal balance were retained as significant predictors of PJK. Conclusion: Even after controlling for extent of correction and preoperative sagittal alignment, PLS reinforcement at UIV+1 using a hand-tensioned nylon tape does not reduce the incidence of PJK at 1 year.
Light rare earth element redistribution during hydrothermal alteration at the Okorusu carbonatite complex, Namibia
Authors: Cangelosi Delia , Broom-Fendley Sam , Banks David , Morgan Daniel , Yardley Bruce 
Published: August 2019

AbstractThe Cretaceous Okorusu carbonatite, Namibia, includes diopside-bearing and pegmatitic calcite carbonatites, both exhibiting hydrothermally altered mineral assemblages. In unaltered carbonatite, Sr, Ba and rare earth elements (REE) are hosted principally by calcite and fluorapatite. However, in hydrothermally altered carbonatites, small (<50 µm) parisite-(Ce) grains are the dominantREEhost, while Ba and Sr are hosted in baryte, celestine, strontianite and witherite. Hydrothermal calcite has a much lower trace-element content than the original, magmatic calcite. Regardless of the lowREEcontents of the hydrothermal calcite, theREEpatterns are similar to those of parisite-(Ce), magmatic minerals and mafic rocks associated with the carbonatites. These similarities suggest that hydrothermal alteration remobilisedREEfrom magmatic minerals, predominantly calcite, without significant fractionation or addition from an external source. Barium and Sr released during alteration were mainly reprecipitated as sulfates. The breakdown of magmatic pyrite into iron hydroxide is inferred to be the main source of sulfate. The behaviour of sulfur suggests that the hydrothermal fluid was somewhat oxidising and it may have been part of a geothermal circulation system. Late hydrothermal massive fluorite replaced the calcite carbonatites at Okorusu and resulted in extensive chemical change, suggesting continued magmatic contributions to the fluid system.
Allergic diseases and long-term risk of autoimmune disorders: longitudinal cohort study and cluster analysis
Authors: Krishna Mamidipudi Thirumala , Subramanian Anuradhaa , Adderley Nicola J. , Zemedikun Dawit T. , Gkoutos Georgios V. , Nirantharakumar Krishnarajah 
Published: August 2019

IntroductionThe association between allergic diseases and autoimmune disorders is not well established. Our objective was to determine incidence rates of autoimmune disorders in allergic rhinitis/conjunctivitis (ARC), atopic eczema and asthma, and to investigate for co-occurring patterns.MethodsThis was a retrospective cohort study (1990–2018) employing data extracted from The Health Improvement Network (UK primary care database). The exposure group comprised ARC, atopic eczema and asthma (all ages). For each exposed patient, up to two randomly selected age- and sex-matched controls with no documented allergic disease were used. Adjusted incidence rate ratios (aIRRs) were calculated using Poisson regression. A cross-sectional study was also conducted employing Association Rule Mining (ARM) to investigate disease clusters.Results782 320, 1 393 570 and 1 049 868 patients with ARC, atopic eczema and asthma, respectively, were included. aIRRs of systemic lupus erythematosus (SLE), Sjögren's syndrome, vitiligo, rheumatoid arthritis, psoriasis, pernicious anaemia, inflammatory bowel disease, coeliac disease and autoimmune thyroiditis were uniformly higher in the three allergic diseases compared with controls. Specifically, aIRRs of SLE (1.45) and Sjögren's syndrome (1.88) were higher in ARC; aIRRs of SLE (1.44), Sjögren's syndrome (1.61) and myasthenia (1.56) were higher in asthma; and aIRRs of SLE (1.86), Sjögren's syndrome (1.48), vitiligo (1.54) and psoriasis (2.41) were higher in atopic eczema. There was no significant effect of the three allergic diseases on multiple sclerosis or of ARC and atopic eczema on myasthenia. Using ARM, allergic diseases clustered with multiple autoimmune disorders. Three age- and sex-related clusters were identified, with a relatively complex pattern in females ≥55 years old.ConclusionsThe long-term risks of autoimmune disorders are significantly higher in patients with allergic diseases. Allergic diseases and autoimmune disorders show age- and sex-related clustering patterns.
Meeting report – Cell dynamics: organelle–cytoskeleton interface
Authors: Mogessie Binyam , Zenner Helen , Renkawitz Jörg 
Published: August 2019

ABSTRACT
A hallmark of eukaryotic cells is the spatial separation of molecular and biochemical processes into membrane-bound organelles, such as mitochondria, endoplasmic reticulum and Golgi. At the ‘Cell dynamics: organelle–cytoskeleton interface’ meeting held in Lisbon, researchers from around the world discussed their findings of how the cytoskeleton regulates dynamics, interaction, and function of organelles in health and disease. Organised by Edgar Gomes, Heidi McBride, Sharon Tooze and Michael Way, the meeting created an open, stimulating and collaborative environment for scientific exchange and an opportunity to highlight the newest trends in the field.
Where is the patient’s chair? Differences in general practitioner consultation room layouts - an exploratory questionnaire
Authors: Floss Mayara , Hoedebecke Kyle , Vidal-Alaball Josep 
Published: August 2019

Background: Health clinic design varies from country to country. The layout of a general practitioner’s (GP’s) consulting room may influence the physician’s or patient’s experience. The aim of this study is to explore and investigate the layout of GP’s consulting rooms around the world and to describe any significant differences. Methods: Between 3rd July and 2nd August 2018, an internet-based questionnaire on Google Docs was distributed by email, social media and WhatsApp platforms to several worldwide rural medicine groups. Analysis of an internet-based questionnaire to explore possible layouts of consultation rooms within practices was performed. The questionnaire was designed with three distinct sections: first, a GP demographic profile including gender, year of graduation from medical school, country of graduation, and type of practice (private or public); second, questions relating to the office layout; third, a section for questionnaire feedback. Results: 502 responses to the questionnaire were received; 65.3% women and 34.7% men. The most common layout in Europe and America was where the physician and the patient were separated by a desk. The layout where the physician and the patient had a 90º angle facing each other was the most commonly used layout in Asia-Australia and Africa. For GPs who graduated before 1990 and between 1990-2010, the layout where the table was between the patient and physician was preferred. However, physicians graduating after 2010 preferred a layout with the physician and the patient with a 90º angle facing each other. Conclusion: The position of the GP’s desk differs between and within countries as well as the gender of the physician and year of graduation. Next steps should focus on gathering an even greater breadth of GP input, as well as comparing and contrasting those to the preferences of our patients and communities.
Willingness-to-pay for a hypothetical Ebola vaccine in Indonesia: A cross-sectional study in Aceh
Authors: Mudatsir Mudatsir , Anwar Samsul , Fajar Jonny Karunia , Yufika Amanda , Ferdian Muhammad N. , Salwiyadi Salwiyadi , Imanda Aga S. , Azhars Roully , Ilham Darul , Timur Arya U. , Sahputri Juwita , Yordani Ricky , Pramana Setia , Rajamoorthy Yogambigai , Wagner Abram L. , Jamil Kurnia F. , Harapan Harapan 
Published: August 2019

Background: Some Ebola vaccines have been developed and tested in phase III clinical trials. However, assessment of whether public have willingness to purchase or not, especially in unaffected areas, is lacking. The aim of this study was to determine willingness to pay (WTP) for a hypothetical Ebola vaccine in Indonesia. Methods: A cross-sectional study was conducted from 1 August to 30 December 2015 in five cities in Aceh province of Indonesia. Patients’ family members who visited outpatient departments were approached and interviewed about their sociodemographic characteristics, knowledge of Ebola, attitude towards vaccination practice and their WTP for a hypothetical Ebola vaccine. A multivariable linear regression model assessed the relationship between these explanatory variables and WTP. Results: During the study, 500 participants were approached and interviewed. There were 424 (84.8%) respondents who completed the interview and 74% (311/424) expressed their acceptance for an Ebola vaccine. There were 288 participants who were willing to pay for an Ebola vaccine (92.6% out of 311). The mean of WTP was US$2.08 (95% CI: 1.75-2.42). The final multivariable model indicated that young age, high educational attainment, working as a private employee, entrepreneur or civil servant (compared to farmers), being unmarried, and residing in a suburb (compared to a city) were associated with higher WTP. Conclusions: Although the proportion of the participants who would accept the Ebola vaccine was relatively high, the amount they were willing to pay for Ebola vaccine was very low. This finding would indicate the need of subsidies for Ebola vaccine in the country.
Coping with stress and hypertension-mediated organ damage
Authors: Popiołek Lech , Dzieża-Grudnik Anna , Siga Olga , Popiołek Iwona , Moląg Małgorzata , Królczyk Jarosław , Grodzicki Tomasz , Walczewska Jolanta , Rutkowski Krzysztof 
Published: August 2019

Aim of the studyChronic exposure to high blood pressure may lead to the development of hypertension-mediated organ damage (HMOD). This study compares styles and strategies of coping with stress in hypertensive patients with arterial stiffness or left ventricular hypertrophy (LVH) and in individuals with hypertension, but without HMOD.Subject or material and methodsEach study participant (n=93) underwent the following procedures: clinical assessment, echocardiography, pulse wave velocity measurement and psychological testing. Blood pressure in the study group was measured using ABPM method. Carotid-femoral pulse wave velocity (PWV) was assessed to identify patients with arterial stiffness. Left ventricular mass index was measured to diagnose LVH. Each patient was also assessed using three psychometric tools: PSS-10, CISS and Brief COPE.ResultsSubjects with arterial stiffness (increased PWV) scored significantly lower than patients with normal PWV in three scales: CISS Avoidance-oriented coping (39 vs. 41.5; p=0.042), Brief COPE Self-distraction (1.5 vs. 2; p=0.013) and Brief COPE Venting (1 vs. 1.5; p=0.037). Individuals with LVH had significantly lower results in Brief COPE scale Use of emotional support scale than hypertensive subjects with normal values of left ventricular mass index (1.5 vs. 2; p=0.041).DiscussionIn our study group hypertensive patients with HMOD preferred different coping styles and strategies than individuals with hypertension, but without vascular and cardiac damage. It is possible that some coping styles and strategies may moderate the risk of HMOD.ConclusionsHMOD may be associated with coping styles and strategies, but future research in this field is necessary to fully understand results of this study.
Kelas Ibu Hamil Merubah Persepsi Budaya Pantang Makan Ibu Hamil Di Kecamatan Tlogowungu Kabupaten Pati
Authors: Mardiyati Risna Annisa 
Published: August 2019

<p><strong>Pendahuluan</strong>: Status gizi merupakan salah satu faktor yang mempengaruhi kehamilan. Banyak wanita yang tidak mengetahui manfaat zat gizi bagi kehamilan. Masyarakat masih percaya adanya hubungan antara makanan tertentu dengan kesehatan ibu hamil serta bayi yang dikandungnya. Hal inilah yang menjadikan tugas tenaga kesehatan untuk mengedukasi ibu hamil salah satunya dengan kelas ibu hamil. Penelitian ini bertujuan untuk mengetahui pengaruh kelas ibu hamil terhadap pandangan mitos pantang makan di Kecamatan Tlogowungu Kabupaten Pati.</p><p><strong>Metode:</strong> Penelitian ini bersifat kualitatif dengan pendekatan fenomenologi. Penarikan sampel menggunakan teknik <em>purposive sampling</em>. Pengambilan data menggunakan teknik wawancara <em>Focus Group Interview</em> (FGI) dan kuesioner sebagai pendukung wawancara. Penelitian ini memilih 18 responden kelas ibu hamil yang dibagi menjadi 3 kelompok <em>focus group interview</em> yang tinggal di Desa Sambirejo, Desa Wonorejo, dan Desa Regaloh, Kecamatan Tlogowungu Kabupaten Pati pada bulan Maret 2018.</p><p><strong>Hasil</strong>: Hasil penelitian terbagi menjadi 3 tema yaitu pengaruh kelas hamil terhadap ibu hamil tentang pengetahuan dan sikap mitos pantang makan selama kehamilan, pengaruh kelas hamil terhadap pengetahuan dan sikap suami ibu hamil dan pengaruh kelas hamil terhadap sikap serta pengetahuan keluarga ibu hamil.</p><p><strong>Simpulan:</strong> Kelas ibu hamil berpengaruh terhadap pengetahuan ibu hamil di Kecamatan Tlogowungu Kabupaten Pati namun belum sampai merubah sikap mereka terhadap mitos pantang makan</p>
Efek Antihistamin Ekstrak Daun Jambu Biji (Psidium guajava) pada Tikus Putih (Rattus norvegicus) dengan Induksi Ovalbumin
Authors: Kawuri Wahyu Tri , Yudhani Ratih Dewi , Setyawan Novan Adi 
Published: August 2019

<p><strong>Pendahuluan</strong><strong>: </strong>Data <em>World Allergy Organization </em>(WAO) tahun 2013 menunjukkan bahwa prevalensi alergi diperkirakan sekitar 30-40% dari populasi dunia. Reaksi alergi terjadi akibat pelepasan histamin oleh sel mast. Pengobatan alergi jangka panjang selama ini memiliki efek samping berupa ganggun kardiovaskuler, retensi urin, AGEP, dan gangguan saraf. Penelitian sebelumnya menunjukkan kuersetin mampu menghambat pelepasan histamin oleh sel mast. Pada analisis kimia, daun jambu biji mengandung kuersetin. Penelitian ini bertujuan untuk mengetahui efek antihistamin ekstrak daun jambu biji (<em>Psidium guajava</em>) pada tikus putih (<em>Rattus norvegicus</em>) yang diinduksi ovalbumin.</p><p><strong>Metode</strong><strong>:</strong><strong> </strong>Penelitian <em>quasi experimental design </em>dengan metode <em>posttest only group design</em> menggunakan 24 tikus yang dibagi kedalam 6 kelompok secara acak. Kelompok kontrol normal (KN) tanpa perlakuan, kontrol negatif (K-) yang hanya diinduksi ovalbumin, kontrol positif (K+) diberikan metilprednisolon, dan kelompok perlakuan (P1, P2, P3) diberikan ekstrak daun jambu biji dengan dosis, berikut 27 mg/200 gramBB, 54 mg/200 gramBB, dan 108 mg/200 gramBB. Pengamatan efek antihistamin berupa perhitungan rata-rata jumlah garuk tikus. Data dianalisis dengan menggunakan uji <em>One-Way ANOVA</em> dan dilanjutkan uji <em>Post Hoc Tukey.</em></p><p><strong>Hasil</strong><strong>:</strong><strong> </strong>Hasil uji <em>One-Way ANOVA</em> menunjukkan perbedaan rata-rata jumlah garuk tikus antar kelompok perlakuan bermakna secara statistik (p=0,00). Berdasarkan hasil uji <em>Tukey</em>, kelompok K- (45,75±5,50) dibandingkan dengan kelompok KN (2,25±0,96) dan kelompok perlakuan ekstrak daun jambu biji berbagai dosis menunjukkan perbedaan rata-rata jumlah garuk tikus yang bermakna secara statistik (p=0,00). Hasil rata-rata jumlah garuk tikus pada kelompok KN (2,25±0,96) dibandingkan dengan P2 (9,00±0,82) tidak menunjukan perbedaan yang bermakna secara statistik (p=0,085).</p><p><strong>Kesimpulan</strong><strong>: </strong>Ekstrak daun jambu biji (<em>Psidium guajava</em>) memiliki efek antihistamin pada tikus putih (<em>Rattus norvegicus</em>) yang diinduksi ovalbumin.</p>
Spontaneous Pneumomediastinum, Pneumoperitoneum, and Pneumoretroperitoneum After Endoscopic Cryoablation Without Frank Perforation
Authors: Chen Brendan , Ferreira Jason 
Published: August 2019

ABSTRACT
Perforation after endoscopic cryoablation is a rare but serious complication. We present a middle-aged male patient who presented for an elective session of endoscopic cryoablation for his Barrett esophagus with high-grade dysplasia. After cryoablation, the patient complained of abdominal pain, and his abdomen became distended and tympanic. Computed tomography showed pneumomediastinum, pneumoperitoneum, and pneumoretroperitoneum but no evidence of extraluminal contrast extravasation. The patient was treated with antibiotics and had no complications. To our knowledge, this is the first described case of pneumomediastinum, pneumoperitoneum, and pneumoretroperitoneum without frank perforation after endoscopic cryoablation.
Citizen science – bridging the gap between scientists and amateurs
Authors: Urválková Eva Stratilová , Janoušková Svatava 
Published: August 2019

Abstract
The European Union has been facing common issues such as early school leaving and lifelong learning for years. They are main targets that remain on the EU agenda and all good practice examples are welcome. Citizen science is one of the approaches that seems to have great potential to draw a wide group of people to science in a popular way. People can easily become a part of a scientific team and contribute to research that could hardly be carried out by one small team. Many citizen science researchers deal with issues that are attractive for people because of their usefulness or application (gathering ticks, taking photographs of surroundings) and/or because of the accessibility of the data (typical for biological issues). This aspect also supports bridging the gap between citizens-amateurs and scientists-professionals, as well as lifelong learning. Chemistry is a natural science subject that is rarely performed in citizen science, and little research is devoted to the educational aspect of citizen science projects. Therefore, we present here a brief overview of an increasing scientific design that is widely used in natural science, although rarely in chemistry. Citizen science seems to be a potentially useful tool for improving chemistry education.