bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of contact ultrasonic power on moisture migration during far‐infrared radiation drying of kiwifruit
Authors: Liu Yunhong , Zeng Ya , Hu Runrun , Sun Xue 
Published: August 2019

AbstractIn order to explore the effect of direct contact ultrasound (DCU) on moisture migration during far‐infrared radiation (FIR) drying of kiwifruit, the drying characteristics, microstructure, water status, and moisture change of kiwifruit slices during drying were investigated based on scanning electron microscopy (SEM), low‐field nuclear magnetic resonance (LF‐NMR), and magnetic resonance imaging (MRI). The results showed that the drying time at ultrasonic power of 54 W was 40% shorter than that without DCU application. SEM observation verified that higher ultrasonic power could produce more and larger microcapillaries in the microstructure of kiwifruit slices, which was beneficial for moisture migration. LF‐NMR detection indicated that water mobility and distribution in kiwifruits changed during drying. The relative proportion of free water in kiwifruits decreased from 70 to 0% with the prolongation drying time at different ultrasonic powers, the removal time for free water at ultrasonic power of 54 W was 57% shorter than that without DCU application during FIR drying, and higher ultrasonic power could accelerate the shifting of water in different states. MRI results illustrated that the DCU application at higher ultrasonic power could promote moisture migration and water removal during FIR drying, and then increase drying rate.Practical applicationsDrying is a commonly utilized process method in food and agricultural industry. Far‐infrared radiation (FIR) drying, as one of the modern drying methods, has desirable advantages including high‐energy efficiency and uniform heating. However, it has unsatisfied promoting effect on internal mass transfer. Ultrasound has significant positive effect on moisture diffusion and water removal. In this study, direct contact ultrasound (DCU) was applied in FIR drying of kiwifruit slices. The study verified that the DCU application in FIR drying could promote drying rate, produce loose microstructure, and shorten drying time significantly. The increase in ultrasonic power could accelerate moisture migration and mass transfer to facilitate water removal. Therefore, DCU application with higher ultrasonic power is beneficial to increasing drying rate and reducing drying time of FIR drying, and FIR drying technology combined with DCU is promising in food industry and can be developed for other food products.
The diagnostic performance of novel torque technique for endoscopic ultrasound‐guided tissue acquisition in solid pancreatic lesions: A prospective randomized controlled trial
Authors: Park Se Woo , Lee Sang Soo , Song Tae Jun , Koh Dong Hee , Hyun Bomi , Chung Doocheol , Lee Jin , Shin Eun , Hong Seung‐Mo , Park Chan Hyuk 
Published: August 2019

AbstractBackground and AimAlthough several techniques for improved outcomes in endoscopic ultrasound (EUS)‐guided tissue acquisition have been reported, the reported diagnostic yield for pancreatic masses is not satisfactory. The effects of novel technique (torque method) on twisting the scope in the clockwise or counterclockwise direction during EUS‐fine needle biopsy (EUS‐FNB) are unknown. We compared the diagnostic yield of EUS‐FNB for pancreatic masses using the torque and standard techniques.MethodsFrom April 20, 2017, to March 16, 2018, 124 consecutive patients with solid pancreatic mass who underwent EUS‐FNB using either the torque or standard technique were randomly assigned. Three passes were made with each technique, comprising 10 uniform to‐and‐fro movements on each pass with a 10‐mL syringe suction. The primary outcome was procurement rates of histologic cores, and the secondary outcomes were the diagnostic performance and technical failure.ResultsThere were significant differences between the groups regarding the procurement rate of the histologic core and optimal quality core (standard vs torque: 87.1% [54/62] vs 98.4% [61/62], P = 0.038 and 79.0% [49/62] vs 93.5% [58/62], P = 0.037). The sensitivity, specificity, positive predictive value, and negative predictive values of EUS‐FNB were 85.45%, 100%, 100%, and 46.67%, respectively, for the standard technique and 96.49%, 100%, 100%, and 71.43%, respectively, for the torque technique. The diagnostic accuracies of the standard and torque techniques were 87.10% and 96.77%, respectively.ConclusionsThe torque technique for EUS‐FNB offered acceptable technical feasibility and superior diagnostic performance, including optimal histologic core procurement, compared with the standard technique.
Retinal ganglion cell topography and spatial resolution estimation in the Japanese tree frog Hyla japonica (Günther, 1859)
Authors: Pushchin Igor 
Published: August 2019

AbstractTree frogs are an interesting and diverse group of frogs. They display a number of unique adaptations to life in the arboreal environment. Vision plays a crucial role in their ecology. The topography of retinal ganglion cells (GCs) is closely related to a species’ visual behavior. Despite a large amount of research addressing GC topography in vertebrates, there is scarce data on this subject in tree frogs. I studied the topography of GCs in the retina of the Japanese tree frog Hyla japonica. The GC density distribution was locally fairly homogeneous, with spatial density increasing gradually from the dorsal and ventral periphery towards the equator. A moderately pronounced visual streak was found close to the equator in the dorsal hemiretina, with a distinct area retinae temporalis in the dorsotemporal quadrant potentially subserving binocular vision. The minimum GC density (mean ± SEM, n = 5) was 3060 ± 60 and the maximum 12 800 ± 170 cells/mm2. The total number of GCs was 292 ± 7 × 103. The theoretical anatomical spatial resolution estimated from GC densities and eye optics was lowest in the ventral periphery (ca. 0.9 and 1.3 cycles/degree in air and water, respectively) and highest in the area retinae temporalis (ca. 2.1 and 2.8 cycles/degree). The relatively high GC density and presence of specialized retinal regions in Hyla japonica are consistent with its highly visual behavior. The present findings contribute to our understanding of the relative role of common ancestry and environmental pressure in GC topography variation within Anura.
Stepparental Support to Adult Children: The Diverging Roles of Stepmothers and Stepfathers
Authors: van Houdt Kirsten , Kalmijn Matthijs , Ivanova Katya 
Published: August 2019

AbstractObjectiveThis study examines the support from stepparents to adult children and considers the role of the composition of the parent network, that is, the presence or absence of the biological mother or father.BackgroundGoing beyond previous research that compared the support provided by different types of parental households, this study provides deeper insights into adult stepfamily dynamics by considering support transfers on the stepparent–stepchild dyad level.MethodThe analyses were based on data from the Ouders en Kinderen in Nederland (Parents and Children in the Netherlands) survey, which was conducted among a stratified random sample of Dutch adults (aged 25–45) with stepparents reporting on support from each of their stepparents (N = 4,351) and biological parents (N = 5,460) separately.ResultsThe results revealed different stories for stepmothers and stepfathers. Within‐child analyses showed that, controlled for the duration of coresidence, children received less types of support from their stepmother than from their biological mother, whereas among fathers, the stepfather provided more. When compared between children, stepmothers provided less types of support if their stepchild's biological mother was still alive, whereas stepfathers' support was unaffected by the biological father's presence. Stepparents of both genders provided less types of support if their partner (i.e., the child's biological parent) was deceased.ConclusionThese findings articulate the central role of the biological mother in postseparation families and the ambiguous position of the stepmother and “widowed stepparents.”
Solitary fibrous tumour of the oral cavity: An update
Authors: Nunes Fernanda Bispo , Sant'Ana Maria Sissa Pereira , Silva André Myller Barbosa , Agostini Michelle , Silva Canedo Nathalie Henriques , de Andrade Bruno Augusto Benevenuto , Romañach Mário José , Corrêa Davi Lavareda , Tomasi Ramiro Alejandro , Radhakrishnan Raghu , Gomez Ricardo Santiago , de Sousa Silvia Ferreira , Brennan Peter A. , Fonseca Felipe Paiva 
Published: August 2019

AbstractBackgroundSolitary fibrous tumour is an unusual neoplasm of the oral cavity that is sometimes not clinically distinguishable from other lesions. The purpose of the present study was to review the clinical, microscopic and molecular aspects of malignant and benign solitary fibrous tumour of the oral cavity currently available in literature.MethodsFor our review, an electronic search was performed using PubMed, Scopus, Ovid/MedLine, Web of science and ProQuest Dissertations and Theses Global database.ResultsA total of 74 publications reporting 150 cases were included. Oral solitary fibrous tumours are most frequently described as submucosal, well‐circumscribed, asymptomatic nodule, more prevalent in females in their fourth to fifth decades of life. Buccal mucosa is the most commonly affected site by the benign tumour variant, whereas the tongue is the most common location affected by the malignant form of the neoplasm. Most of the lesions were treated by conservative surgery. One recurrent malignant tumour and one metastasis are reported.ConclusionAsymptomatic normal‐coloured submucosal nodules located in the buccal mucosa and tongue in adult patients are suggestive of oral solitary fibrous tumour, but only a careful microscopic examination can differentiate benign from malignant variants and the use of immunohistochemistry (CD34, Bcl‐2, CD99 and STAT6), and cytogenetic studies (NAB2‐STAT6) contribute significantly to confirm the diagnosis of solitary fibrous tumour in difficult cases.
Development of a bioassay to assess resistance to Fusarium oxysporum (Schlecht.) in asparagus (Asparagus officinalis L.)
Authors: Kathe Lena , Krämer Reiner , Budahn Holger , Pillen Klaus , Rabenstein Frank , Nothnagel Thomas 
Published: August 2019

AbstractFusarium oxysporum is one of the major pathogens causing root and crown rot in asparagus. Breeding of cultivars resistant to F. oxysporum would be the most efficient strategy for pathogen control. In this study, a bioassay was developed for screening seedling resistance. The non‐destructive bioassay comprises inoculation with a highly aggressive F. oxysporum isolate, incubation in a climate chamber and quantification of disease symptoms by a digital image analysing system and a PTA‐ELISA. This bioassay is simple to implement and demonstrated high reproducibility. Subsequently, it was used to determine the resistance behaviour of 16 asparagus genotypes to F. oxysporum. The asparagus cultivars revealed different levels of susceptibility, whereas the wild relative A. densiflorus was confirmed to be resistant.
Pharmacokinetics of mycophenolic acid and its effect on CD4+ and CD8+ T cells after oral administration of mycophenolate mofetil to healthy cats
Authors: Slovak Jennifer E. , Hwang Julianne K. , Rivera Sol M. , Villarino Nicolas F. 
Published: August 2019

AbstractBackgroundMycophenolate mofetil (MMF) is an immunosuppressant used in human and veterinary medicine. Little pharmacokinetic and pharmacodynamic information on MMF is available in cats.ObjectiveTo evaluate the plasma disposition of mycophenolic acid (MPA) and assess its effect on total peripheral blood mononuclear cells and CD4+/CD8+ ratios after PO administration of MMF.AnimalsHealthy cats (n = 10).MethodsMycophenolate mofetil was administered at a dosage of 10 mg/kg q12h (n = 3), 15 mg/kg q12h (n = 3), and 15 mg/kg q8h (n = 4) for 7 days. Concentrations of MPA and derivatives were determined using ultra‐high‐performance liquid chromatography. Flow cytometry was used to assess CD4+/CD8+ T‐cell ratios.ResultsAll cats biotransformed MMF into MPA. Half of the cats (5/10) had adverse effects within 1 week of MMF administration. Area under the curve limit of quantification (AUC0‐LOQh) of MPA ranged from 1.27 to 2.03 hours·μg/mL and from 1.77 to 8.54 hours·μg/mL after the first and last PO dose of 10 mg/kg. The AUC0‐loqh of MPA ranged from 2.18 to 31 hours·μg/mL after the first dose of 15 mg/kg of MMF. Before the first dose of MMF, the average total number of PBMC ranged from 1.2 to 9.3 million/mL. At the last dose of MMF, the average total number of PBMC ranged from 3 to 5 million/mL.ConclusionMycophenolic acid was detected in all cats. The dose 10 mg/kg given q12h for 1 week was tolerated (n = 3). The efficacy of MMF as an immunosuppressant and long‐term safety in cats of this dosage regimen is unknown.
Population pharmacokinetics for danofloxacin in the intestinal contents of healthy and infected chickens
Authors: Tian Erjie , Chen Chunli , Hu Wanjun , Miao Yusong , Muhammad Ishfaq , Zhang Qiaomei , Liu Yuhao , Xu Liang , Bao Jiaxin , Ding Liangjun , Li Jichang 
Published: August 2019

AbstractAvian pathogenic Escherichia coli could cause localized and systemic infection in the poultry, and danofloxacin is usually used to treat avian colibacillosis through oral administration. To promote prudent use of danofloxacin and reduce the emergence of drug‐resistant E. coli strains, it is necessary to understand the population pharmacokinetics (PopPK) of danofloxacin in chicken intestines. In this study, reversed‐phase high performance liquid chromatography (HPLC) with fluorescence detection was used to detect the concentrations of danofloxacin in the contents of duodenum, jejunum, and ileum of the healthy and infected chickens after single oral administration (5 mg/kg body weight). Then, the PopPK of danofloxacin in intestines were analyzed using NONMEM software. As a result, a two‐compartment PK model best described the time‐concentration profile of duodenal, jejunal, and ileal contents. Interestingly, absorption rate (Ka), distribution volume (V), and clearance (CL) for danofloxacin from duodenal, jejunal to ileal contents were sequentially decreased in the healthy chickens. However, the trend of Ka, V, and CL of danofloxacin was changed dramatically in the intestine of infected chickens. Ka and V of danofloxacin in the jejunum were higher than in the ileum and duodenum. Compared with healthy chickens, Ka and V of danofloxacin in the duodenum decreased significantly, while increased in jejunum, respectively. It has been noted that Ka decreased and V increased in the ileum of infected chickens. Besides, CL in the duodenum, jejunum, and ileum of infected chickens was, respectively, lower than those of healthy chickens. Interestingly, the relative bioavailability (F) of danofloxacin in the ileum was relatively higher in both healthy and infected chickens. In addition, F in the duodenal, jejunal, and ileal contents of infected chickens was respectively higher than healthy chickens. In summary, the PopPK for danofloxacin in infected chicken intestines was quite different from healthy chickens. The absorption, distribution, and clearance of danofloxacin in healthy chickens decreased from duodenum to jejunum and to ileum. Moreover, the pharmacokinetic characteristics in the intestine of infected chickens changed significantly, and the pharmacokinetic characteristics in the ileum can be used as a representative of all intestinal segments.
Association of abdominal aortic calcification estimated by plain radiography with outcomes in haemodialysis patients: A 6‐year follow‐up study
Authors: Zhu Xuying , Cai Hong , Zhu Minxia , Zhan Yaping , Che Miaolin , Lin Xinghui , Zhang Weiming , Ni Zhaohui 
Published: August 2019

ABSTRACTAimVascular calcification has played a vital role in increasing the prevalence of cardiovascular disease (CVD) and mortality in maintenance haemodialysis (MHD) patients. This study is aimed at exploring the prognostic value of abdominal aortic calcification (AAC) estimated by plain lateral abdominal radiography in MHD patients.MethodsLateral abdominal radiography was used to determine the abdominal aortic calcification score (AACS). The serum level of fibroblast growth factor‐23 was tested by enzyme‐linked immunosorbent assay. Patients were divided into two groups: no or minor calcification group (AACS < 5) and moderate to severe calcification group (AACS ≥ 5). All patients were followed up to death or the end of the study (30 November 2016).ResultsA total of 114 patients were enrolled in this study, including 64 males (56.1%), and the mean age was 57.42 ± 13.48 years. Seventy‐six patients (66.7%) exhibited AAC. Independent predictors for moderate to severe calcification were older age (odds ratio (OR) 1.06 (1.02–1.10), P = 0.003), longer dialysis vintage (OR 1.01 (1.00–1.02), P = 0.039), presence of smoking (OR 3.01 (1.18–7.70), P = 0.021) and higher Log fibroblast growth factor‐23 serum levels (OR 2.83 (1.01–7.94), P = 0.048). During a median follow‐up of 6.0 (5.6, 6.1) years, 22 patients (19.3%) died of all‐cause death, and 17 cases (14.9%) died of CVD. Kaplan–Meier survival curves showed that patients in the moderate to severe calcification group had significantly higher all‐cause (28.3 vs 11.5%, P = 0.028) and CVD mortality (22.6 vs 8.2%, P = 0.035) than that in the no or minor calcification group. A multivariate Cox regression showed that AACS (hazard ratio 1.08 (1.01–1.15), P = 0.022) was an independent predictor of CVD mortality. Compared with the no or minor calcification group, the risk of CVD mortality was increased by a factor of 3.14 in patients in the moderate to severe calcification group (hazard ratio 3.14 (1.04–9.44), P = 0.042).ConclusionOur data suggest that AAC is prevalent in MHD patients and could provide potential predictive information for CVD mortality. Plain lateral abdominal radiography, which is simple and cheap and involves lower radiation, might represent an appropriate screening method for evaluating vascular calcification in daily clinical practice.
Progranulin promotes diabetic fracture healing in mice with type 1 diabetes
Authors: Wei Jianlu , Zhang Lei , Ding Yuanjing , Liu Ronghan , Guo Yuqi , Hettinghouse Aubryanna , Buza John , De La Croix Jean , Li Xin , Einhorn Thomas A. , Liu Chuan‐ju 
Published: August 2019

AbstractType 1 diabetes mellitus (T1DM) is an autoimmune disease characterized by insulin deficiency, and patients with diabetes have an increased risk of bone fracture and significantly impaired fracture healing. Proinflammatory cytokine tumor necrosis factor‐alpha is significantly upregulated in diabetic fractures and is believed to underlie delayed fracture healing commonly observed in diabetes. Our previous genetic screen for the binding partners of progranulin (PGRN), a growth factor‐like molecule that induces chondrogenesis, led to the identification of tumor necrosis factor receptors (TNFRs) as the PGRN‐binding receptors. In this study, we employed several in vivo models to ascertain whether PGRN has therapeutic effects in diabetic fracture healing. Here, we report that deletion of PGRN significantly delayed bone fracture healing and aggravated inflammation in the fracture models of mice with T1DM. In contrast, recombinant PGRN effectively promoted diabetic fracture healing by inhibiting inflammation and enhancing chondrogenesis. In addition, both TNFR1 proinflammatory and TNFR2 anti‐inflammatory signaling pathways are involved in PGRN‐stimulated diabetic fracture healing. Collectively, these findings illuminate a novel understanding concerning the role of PGRN in diabetic fracture healing and may have an application in the development of novel therapeutic intervention strategies for diabetic and other types of impaired fracture healing.
miR‐611 promotes the proliferation, migration and invasion of tongue squamous cell carcinoma cells by targeting FOXN3
Authors: Chen Shuai , Zhang Jianyun , Sun Lisha , Li Xuefen , Bai Jiaying , Zhang Heyu , Li Tiejun 
Published: August 2019

AbstractObjectivesThe function of miR‐611 has not yet been reported. We aimed to investigate the effects of miR‐611 on tongue squamous cell carcinoma (TSCC) and the underlying mechanism.Materials and MethodsThe expression level of miR‐611 in TSCC tissues was measured using quantitative reverse transcriptase–polymerase chain reaction (RT‐qPCR). Cell proliferation, migration and invasion were examined by performing CCK‐8, IncuCyte and Transwell assays. Bioinformatics analyses and microarrays were used to screen for target genes, which were verified using a luciferase reporter assay, RT‐qPCR and Western blotting. The xenograft model was used to assess the effects of miR‐611 in vivo.ResultsmiR‐611 was upregulated in TSCC tissues, which was significantly correlated with TNM stage and negatively associated with the overall survival of patients. In addition, upregulation of miR‐611 not only potentiated the proliferation, migration, invasion and epithelial–mesenchymal transition (EMT) of TSCC cells in vitro, but also promoted tumour growth in vivo. FOXN3 was identified as a candidate target gene of miR‐611 and subsequently verified. Finally, miR‐611 induced a malignant phenotype of TSCC, which was rescued by overexpression of FOXN3.ConclusionsOur findings suggest that miR‐611 is a novel therapeutic target for TSCC.
A conservative transnasal endoscopic and intraoral approach in a case of a maxillary dentigerous cyst
Authors: Consolo U. , Bellini P. , Mattioli F. , Lizio G. 
Published: August 2019

AbstractThe transoral approach for enucleation of a voluminous odontogenic lesion involving the maxillary sinus is considerably invasive and can cause irreversible damage to the ciliated mucosa with definitive loss of the normal bone morphology. Functional endoscopic sinus surgery (FESS), which increases the patency of the osteomeatal complex (OMC), involves the use of a direct approach to the lesion, facilitating the drainage of secretions and improving the ventilation. Nevertheless, FESS cannot completely enucleate large odontogenic cystic lesions, particularly dentigerous cysts associated with dislocated teeth. Accordingly, a combined transnasal endoscopic and transoral approach is desirable. Here, we report the successful use of FESS combined with a conservative intraoral approach for the treatment of a voluminous dentigerous cyst that completely occupied the maxillary sinus. In a single surgery, FESS was used to enlarge OMC and open the cystic compartment into the nasal cavity, while an intraoral approach involving the removal of a bony lid from the anterolateral wall of the maxillary sinus facilitated minimal removal of the cystic wall associated with the dislocated tooth. The bony lid was repositioned and fixed with titanium plates. Computed tomography performed at 6 months showed that the original cystic compartment, which maintained communication with the nasal cavity through the enlarged OMC, was absent, and that the sinus had recovered its healthy morphology. Computed tomography at 27 months showed the maintenance of this status with no signs of recurrence. We recommend this approach to eradicate such pathology while preserving the sinus structure and function.
A rare case of purpuric rash caused by Saprochaete clavata in a pediatric patient with acute leukemia
Authors: Wee Lynette Wei Yi , Ling Hua Yen , Chong Chia Yin , Soe Mya Nwe , Koh Mark Jean Aan 
Published: August 2019

AbstractWe present a 13‐year‐old boy who developed invasive infection with Saprochaete clavata after induction chemotherapy for B‐cell acute lymphoblastic leukemia, complicated by fungemia, septic shock and acute renal, and liver failure. He developed purpuric papulonodules over bilateral upper and lower limbs, which also grew S clavata on fungal culture.