bluuebunny/crossref_metadata_2025_split huggingface dataset:
Rischio clinico in sanità e prevenzione dei rischi del paziente ricoverato in ospedale
Authors: La Regina Guest Editors: M. , Romano E. , Tardivo S. , Trinchero E. 
Published: July 2019

L’approccio sistemico alla gestione dei rischi in sanitàE. Trinchero
Rischio clinico e sicurezza del paziente: presente e futuroS. Tardivo, M. Capasso
Rischio clinico: livelli di staffing infermieristico ed esiti correlati alle cure infermieristicheG. Pentella, L. Tesei
Il ruolo delle competenze non tecniche (non technical skill) nella dinamica del rischio clinicoF. Moretti, M. Rimondini
Rischio clinico e carico di lavoro: alcuni spunti di riflessioneP. Gnerre, A. Fontanella, D. Montemurro, C. Palermo

Il punto di vista di un Direttore Generale internistaG. Scannapieco, E. Croci
Il punto di vista di un Direttore Sanitario internistaF. Orlandini
Il punto di vista di un Direttore Sanitario igienistaC. Bovo
Il punto di vista di un Direttore di Medicina InternaS. De Carli

La metà oscura del rischio clinico: i sinistri in medicina internaF. Corradi
La corretta identificazione del pazienteR. Gallo, F. Bertoncini, C. Gatta
Fase diagnostica: evitare misdiagnosi e ritardiM. Giorgi-Pierfranceschi
Sicurezza in terapia farmacologicaE. Romano
Novità nella prevenzione delle caduteR. Re, G. Ferrotti
Protezione dalle infezioni correlate all’assistenzaA. Maffettone, C. Peirce, S. Di Fraia
Safe HandoverR. Rapetti
Prevenzione dei rischi in Medicina Interna, casi particolari: atti autolesivi, vagabondaggio, intrappolamento nel paziente ospedalizzatoR. Nardi, D. Tirotta, G. Pinna, G. Pirini
Gestione ricoveri in appoggio e rischio clinicoM. La Regina, F. Guarneri, T. Bellandi, R. Tartaglia, A. Brucato, D. Manfellotto
Innovazioni organizzative in Medicina Interna per la sicurezza del paziente: dall’Ambulatorio Integrato Diagnostico-Terapeutico alla Sezione di Decisione ClinicaR. Castello, A. Carli

OssigenoterapiaM. La Regina
VentiloterapiaM. La Regina
Strumenti per una gestione sicura delle procedure invasiveM. La Regina
La prevenzione del tromboembolismo venosoF. Pomero, E. Nicola, P. Salomone, R. Risso
Sicurezza nella gestione della terapia anticoagulante oraleM. La Regina, F. Pomero
Strumenti per una gestione sicura delle terapie inalatorieC. Tieri
Strumenti per una gestione sicura della terapia ipoglicemizzanteT.M. Attardo
Strumenti per una gestione sicura delle allergie a farmaci e delle interazioni farmacologicheT.M. Attardo
Mobilizzazione dei pazientiG. Querci, A. Spadaro

Il rischio clinico: conclusioniA. Fontanella
Haemato-biochemical profile and acid–base status of Croatian spotted goats of different ages
Authors: Antunović Zvonko , Marić Ivica , Klir Željka , Šerić Vatroslav , Mioč Boro , Novoselec Josip 
Published: July 2019

Abstract. The aim of the present research was to determine the haemato-biochemical profile and blood acid–base status of Croatian spotted goats in a traditional Mediterranean production system. The 60 non-gravid female Croatian spotted goats of different ages were included in the research. They were divided into four groups of 15 goats according to age: group I – ≤1 year old; group II – 2–3 years; group III – 3–6 years; and group IV – 7–10 years. Haematological parameters were determined in whole blood, biochemical parameters in serum and acid–base status in plasma by automatic analyser. Total leukocyte number (WBC), haemoglobin (HGB) and mean corpuscular volume (MCV) in the blood were the highest, while mean haemoglobin concentration in erythrocytes (MCHCs) was the lowest in yearlings compared to other groups. Concentrations of urea, Mg, Cl, non-esterified fatty acids (NEFAs) and lactate were the highest in yearlings. Concentrations of Ca, Na, total cholesterol, high-density lipoprotein (HDL), very low-density lipoprotein (VLDL) and beta hydroxybutyrate (BHB) as well as the activity of alanine aminotransferase (ALT) were higher in older goats compared to yearlings, while the opposite was determined for the activities of creatine kinase (CK) and alkaline phosphatase (ALP). Values of pH, the strong ion difference (SID), anion gap (AG) and z values as well as the content of HCO3 and total pressure of carbon dioxide (ctCO2) were higher in older goats compared to yearlings. The results obtained may help in monitoring the health and nutritional status and improve the management of Croatian spotted goats. Based on the results of the present study, the effect of age needs to be included in the model when preparing the reference values for the haemato-biochemical profile and acid–base status of goats.
Analysis of a southern sub-polar short-term ozone variation event using a millimetre-wave radiometer
Authors: Orte Pablo Facundo , Wolfram Elian , Salvador Jacobo , Mizuno Akira , Bègue Nelson , Bencherif Hassan , Bali Juan Lucas , D'Elia Raúl , Pazmiño Andrea , Godin-Beekmann Sophie , Ohyama Hirofumi , Quiroga Jonathan 
Published: July 2019

Abstract. Subpolar regions in the Southern Hemisphere are
influenced by the Antarctic polar vortex during austral spring, which
induces high and short-term ozone variability at different altitudes, mainly
into the stratosphere. This variation may affect considerably the total
ozone column changing the harmful UV radiation that reaches the surface. With the aim of studying ozone with a high time resolution at different altitudes
in subpolar regions, a millimetre-wave radiometer (MWR) was installed at the
Observatorio Atmosférico de la Patagonia Austral (OAPA), Río
Gallegos, Argentina (51.6∘ S, 69.3∘ W), in 2011. This instrument provides ozone profiles with a time resolution of
∼1 h, which enables studies of short-term ozone mixing
ratio variability from 25 to ∼70 km in altitude. This work
presents the MWR ozone observations between October 2014 and 2015, focusing
on an atypical event of the polar vortex and Antarctic ozone hole influence
over Río Gallegos detected from the MWR measurements at 27 and 37 km
during November of 2014. During the event, the MWR observations at both
altitudes show a decrease in ozone followed by a local peak of ozone amount
of the order of hours. This local recovery is observed thanks to the high
time resolution of the MWR mentioned. The advected potential vorticity (APV)
calculated from the MIMOSA high-resolution advection model (Modélisation
Isentrope du transport Méso-échelle de l'Ozone Stratosphérique
par Advection) was also analysed at two isentropic levels (levels of
constant potential temperature) of 675 and 950 K (∼27 and
∼37 km of altitude, respectively) to understand and explain
the dynamics at both altitudes and correlate the ozone rapid recovery with
the passage of a tongue with low PV values over Río Gallegos. In
addition, the MWR dataset was compared for the first time with measurements
obtained from the Microwave Limb Sounder (MLS) at individual altitude levels (27, 37 and 65 km) and with the differential absorption lidar (DIAL)
installed in the OAPA to analyse the correspondence between the MWR and
independent instruments. The MWR–MLS comparison presents a reasonable
correlation with mean bias errors of +5 %, −11 % and −7 % at 27,
37 and 65 km, respectively. The MWR–DIAL comparison at 27 km also presents
good agreement, with a mean bias error of −1 %.
Pre-Press The Patient as a Reader
Authors: Bernhardsson Katarina 
Published: July 2019

Illness narratives can be said to reclaim the voice of the patient, and while they draw much of their strength from a position of experience and loss, they are also highly mediated and constructed narratives. This article studies, how these textual self-representations are formed in relation to intertexts, and how the authors explicitly use other literary texts and enter into a dialogue with them.
Two pathographies are studied, Anders Paulrud’s Fjärilen i min hjärna (“The Butterfly in my Brain”, 2008) and Agneta Klingspor’s Stängt pga hälsosjäl (“Closed due to health reasons”, 2010, and their specific strategies in incorporating other literary texts: Paulrud through assemblage and community, and Klingspor through resistance and critique, especially of narratives the author feels she is supposed to appreciate. In the end, both authors seem to share a view about literature as potentially helpful and meaningful in conveying experiences and even point to a healing potential in narratives and literature.
La contratación pública responsable. Diseño de indicadores de medición
Authors: Gutiérrez Ponce Herenia , Nevado Gil María Teresa , Pache Durán María 
Published: July 2019

Actualmente, la UE, reconoce la importancia de la contratación pública como uno de los instrumentos que deben utilizarse para lograr un crecimiento inteligente, sostenible e integrador. En España, la Ley 9/2017, de 8 de noviembre, de Contratos del Sector Público, por la que se transponen al ordenamiento jurídico español las Directivas del Parlamento Europeo y del Consejo 2014/23/UE y 2014/24/UE, recientemente aprobada, plantea incorporar de forma transversal criterios socialmente responsables a la hora de preparar y ejecutar los contratos públicos, de tal forma que obliga a las empresas licitadoras a cumplir requisitos concretos sobre igualdad de género, condiciones laborales justas, consumo de comercio justo o eficiencia energética. Ante esta situación, las administraciones públicas han comenzado a elaborar guías y aprobar instrucciones para la implementación de cláusulas socialmente responsables en sus contrataciones. Sin embargo, a pesar de su importancia, no existe un instrumento de medida específico que evalúe este tipo de conductas. En este contexto, planteamos esta investigación con el objetivo de diseñar indicadores éticos y sostenibles, consistentes con la nueva Ley, que permitan medir y comparar relativamente los comportamientos responsables de las administraciones en relación a sus contrataciones públicas. Para lograr nuestro objetivo, planteamos un estudio exploratorio sobre la información disponible en las páginas web de los municipios españoles. Este instrumento podrá favorecer el enfoque de prácticas y políticas responsables en atención a las carencias observadas, contribuyendo a obtener no solo beneficios ambientales, sino también económicos y sociales, tanto para la Administración como para el sector privado y la sociedad.
Anti-cytoskeleton Immunoscreening of Trypanosoma brucei Expression Library Reveals Novel Immunogenic Conserved Putative Proteins
Authors: Magyezi Begumisa Godfrey , Uthman Okalang , Kenneth Musisi , Mwijjwiga Wampadde Eddie , George Lubega W. 
Published: July 2019

Background: The overall shape of the trypanosome is defined by an internal cytoskeleton consisting of a network of microtubules that are cross linked both to each other and the inner face of the plasma membrane. However, the total compliment and identity of the trypanosome cytoskeleton proteins are not yet fully determined despite the fact that some of them may be good targets for diagnostics, drugs and/or vaccines discovery.
Methods: In this study, rabbit anti-Trypanosoma brucei detergent insoluble cytoskeleton sera were produced in vivo and used to probe a T. brucei expression library. The picked plaques were made clonal by a series of library screening followed by PCR amplification, cDNA sequencing and identification of the proteins coded by these sequences using BLAST.
Results: The previously well-known cytoskeleton proteins (paraflagella rod protein and histone H2B), putative cytoskeleton proteins (Dynein light chain and nucleoporin), conserved hypothetical protein (Tb10.61.2430) and novel cytoskeleton protein coding cDNA sequences (not in the sequenced and published T. brucei genome) were identified in this study.
Conclusion: This approach is therefore, useable in the search for novel proteins whose utility in the design and development of diagnostics, drugs and/or vaccines can further be studied.
Breast Cancer Awareness, Knowledge and Beliefs among Libyan Women
Authors: El-Hamadi Meluda R. , Gusbi Mukhtar , Aisa Mukhtar , Elkout Hajer 
Published: July 2019

Background: Breast cancer (BC) is the most frequent cancer of women. The high mortality in developing countries is associated with late detection, and lack of knowledge and adequate screening programmes.
Aims: To determine breast cancer awareness, knowledge and beliefs among Libyan women.
Study Design: A cross-sectional descriptive study.
Place and Duration of Study: Between September and October 2016 among a sample of adult women in western Libya.
Methods: 1091 woman aged between years were asked to fill a validated questionnaire to investigate their knowledge about the risk factors as well as their awareness and screening behaviours of BC.
Results: The majority of women who participated in the study were aware of BC early warning signs and symptoms. Over 90% of the women were able to list at least one symptom of breast cancer correctly. The most frequent warning sign identified was breast lump (91.0%), followed by discharge from the nipples (80.6%). Also, 565 (52.7%) of those surveyed were aware that increasing age was associated with a higher incidence of breast cancer and 747 (68.3%) of the respondents identified positive family history as a risk factor. Moreover, 62% know how to perform self-examination (BSE), and only 59% ever performed BSE. The majority (92%) would seek medical advice if they discovered a mass in the breast whereas, about half of those (59%) would consult a male doctor.
Conclusions: Women who participated in this study were fairly informed about BC risks and warning signs; the results appear to reflect growing awareness of women regarding BC screening methods. Health education message should be presented and delivered in a culturally-sensitive manner and tailored to provide simple and clear information and avoid false beliefs and misconceptions about the disease, its screening methods and management options.
Assessing population‐based to personalized planning strategies for head and neck adaptive radiotherapy
Authors: Visak Justin , Liao Chien‐Yi , Zhong Xinran , Wang Biling , Domal Sean , Wang Hui‐Ju , Maniscalco Austen , Pompos Arnold , Nyguen Dan , Parsons David , Godley Andrew , Lu Weiguo , Jiang Steve , Moon Dominic , Sher David , Lin Mu‐Han 
Published: December 2024

AbstractPurposeOptimal head‐and‐neck cancer (HNC) treatment planning requires accurate and feasible planning goals to meet dosimetric constraints and generate robust online adaptive treatment plans. A new x‐ray‐based adaptive radiotherapy (ART) treatment planning system (TPS) version 2.0 emulator includes novel methods to drive the planning process including the revised intelligent optimization engine algorithm (IOE2). HNC is among the most challenging and complex sites and heavily depends on planner skill and experience to successfully generate a reference plan. Therefore, we evaluate the new TPS performance via conventionally accepted planning strategies with/without artificial intelligence (AI) and knowledge‐based planning (KBP).MethodsOur institution has a pre‐clinical release of the Varian Ethos2.0 TPS emulator which includes several changes that may affect current planning strategies. Twenty definitive and post‐operative HNC patients were retrospectively selected with a two or three‐level simultaneous integrated boost (SIB) dosing scheme. Patients were replanned in the emulator using population‐based, KBP‐guided with/without human intervention and AI‐guided planning goals. These planning strategies were compared both dosimetrically and for plan deliverability.ResultsAll strategies generally demonstrated acceptable plan quality with KBP‐ and AI‐guided goals offering enhanced dosimetric sparing in organs‐at‐risk (OAR). The average contralateral parotid gland mean dose was 20.0 ± 6.1 Gy (p < 0.001) for population‐based and 15.0 ± 6.1 Gy (p = n.s.) for KBP‐with human intervention versus 15.1 ± 7.4 Gy for clinical plans. Target coverage, minimum dose, and plan hotspot were acceptable in all cases. KBP‐enabled strategy demonstrated higher modulation and faster optimization time than both population‐based and AI‐guided strategies.ConclusionSimply entering population, automatic KBP‐enabled or AI‐generated planning goals into the new Ethos2.0 TPS produced dosimetrically compliant plans, with AI‐guided goals demonstrating the most OAR sparing. Several of these approaches are easy to translate to other treatment sites and will help lower the barrier to entry for x‐ray‐based online‐ART.
Low dose threshold for measuring cardiac functional metrics using four‐dimensional CT with deep learning
Authors: Wu Pengwei , Kim Kyle , Severance Lauren , McVeigh Elliot , Pack Jed Douglas 
Published: December 2024

AbstractBackgroundFour‐dimensional CT is increasingly used for functional cardiac imaging, including prognosis for conditions such as heart failure and post myocardial infarction. However, radiation dose from an acquisition spanning the full cardiac cycle remains a concern. This work investigates the possibility of dose reduction in 4DCT using deep learning (DL)‐based segmentation techniques as an objective observer.MethodsA 3D residual U‐Net was developed for segmentation of left ventricle (LV) myocardium and blood pool. Two networks were trained: Standard DL (trained with only standard‐dose [SD] data) and Noise‐Robust DL (additionally trained with low‐dose data). The primary goal of the proposed DL methods is to serve as an unbiased and consistent observer for functional analysis performance. Functional cardiac metrics including ejection fraction (EF), global longitudinal strain (GLS), circumferential strain (CS), and wall thickness (WT), were measured for an external test set of 250 Cardiac CT volumes reconstructed at five different dose levels.ResultsFunctional metrics obtained from DL segmentations of standard dose images matched well with those from expert manual analysis. Utilizing Standard‐DL, absolute difference between DL‐derived metrics obtained with standard dose data and 100 mA (corresponding to ∼76 ± 13% dose reduction) data was less than 0.8 ± 1.0% for EF, GLS, and CS, and 5.6 ± 6.7% for Average WT. Performance variation of Noise‐Robust DL remained acceptable at even 50 mA.ConclusionWe demonstrate that on average radiation dose can be reduced by a factor of 5 while introducing minimal changes to global functional metrics (especially EF, GLS, and CS). The robustness to reduced image quality can be further boosted by using emulated low‐dose data in the DL training set.
Verification of daily dose recalculation accuracy for an adaptive radiation therapy monitoring tool in helical tomotherapy for nasopharyngeal carcinoma
Authors: Maneepan Yawitta , Watcharawipha Anirut , Chitapanarux Imjai , Wanwilairat Somsak , Nobnop Wannapha 
Published: December 2024

AbstractPurposePreciseART, an adaptive radiation therapy (ART) software for helical tomotherapy (HT), was integrated into the Precision treatment planning system (Accuray, Inc., Sunnyvale, CA). It supports automatic monitoring of dose variations to both the target and organs at risk (OARs) throughout the treatment course. This study aims to verify the accuracy of PreciseART's automatic dose recalculation and assess the effectiveness of its notification function.MethodsThe Radixact X9's kVCT image‐guided system (ClearRT) was used to acquire daily images for dose recalculations. We assessed the accuracy of PreciseART's automatic dose recalculation by comparing it with the treatment planning system (TPS) recalculation for the PTV70, spinal cord, and bilateral parotid glands. We also evaluated the efficacy of its notification function by comparing each dose metric for each notification color to TPS recalculation, assessing its role as a trigger tool.ResultsIn the phantom study, dosimetric analysis indicated no statistically significant differences between TPS and PreciseART recalculations (p > 0.05), with dose variations under 1.5%. Similarly, in the patient study (n = 10), no significant dosimetric discrepancies were found (p > 0.05), with a maximum variation of 2.3%. The notification system performed effectively, providing accurate notifications in accordance with predefined dose criteria.ConclusionsPreciseART's daily dose recalculation demonstrated good agreement with TPS recalculation, and its notification function is effective for identifying dose threshold compliance, supporting its use in clinical ART.
Investigating ITM2B‐associated ataxia in a Taiwanese cerebellar ataxia cohort
Authors: Fang Shih‐Yu , Hsiao Cheng‐Tsung , Jih Kang‐Yang , Tsai Yu‐Sheun , Lai Kuan‐Lin , Chou Cheng‐Ta , Liao Yi‐Chu , Lee Yi‐Chung 
Published: December 2024

AbstractObjectiveThe genetic causes of a significant number of patients with cerebellar ataxia remain unsolved. Variations in the ITM2B gene, typically linked to dominantly inherited dementia, can sometimes present with cerebellar ataxia as an early symptom. This study aims to investigate the role of ITM2B variations in a Taiwanese cohort with unsolved cerebellar ataxia.MethodsGenetic analysis of ITM2B was performed in 212 unrelated Taiwanese patients with unsolved cerebellar ataxia. Eight short tandem repeat markers flanking ITM2B were genotyped to analyze the associated haplotype. Affected carriers underwent comprehensive clinical evaluations.ResultsA heterozygous ITM2B variant, c.800G>T (p.(Ter267LeuextTer11)), was identified in three patients. Haplotype analysis demonstrated a shared haplotype linked to this variant in the three families, suggesting a founder effect. The three probands and additional three affected relatives presented with cerebellar ataxia and unsteady gait with an average onset age of 43.2 years. Most participants had no cognitive impairment at symptom onset but experienced memory decline, oculomotor disturbances, lower limb spasticity, and extensor plantar responses within 2–5 years. Magnetic resonance imaging and spectroscopy revealed progressive extension of white matter hyperintensity over periventricular and subcortical regions, subtle hippocampal atrophy, preserved cerebellar volumes, and decreased N‐acetylaspartate/creatine ratio over the vermis.InterpretationITM2B mutations accounted for 1.4% of cerebellar ataxia cases in the Taiwanese cohort, with patients carrying ITM2B c.800G>T descending from a common ancestor. This study underscores the importance of considering ITM2B variations as a potential cause of cerebellar ataxia, even in the absence of dementia at the initial presentation.
Producing battery grade lithium carbonate from salt‐lake brine via bipolar membrane carbon dioxide mineralization
Authors: Shan Weixiang , Cao Guangzhong , Gu Tianle , Liu Xiao , Sun Dongyue , Fu Rongqiang , Liu Zhaoming , Jiang Chenxiao , Xu Tongwen 
Published: December 2024

AbstractProducing battery‐grade Li2CO3 product from salt‐lake brine is a critical issue for meeting the growing demand of the lithium‐ion battery industry. Traditional procedures include Na2CO3 precipitation and multi‐stage crystallization for refining, resulting in significant lithium loss and undesired lithium product quality. Herein, we first proposed a bipolar membrane CO2 mineralization technique for directly producing battery‐grade Li2CO3 from lake brine that enriches alkali metals (Na+, K+). Results indicate the process can successfully separate Li+ from contaminants and present a selectivity above 900 for Li+ through the CO2 mineralization reaction, while prevent electro‐oxidating Cl− to Cl2 pollution. The obtained Li2CO3 production purity is above 99.75% with lithium recovery rate of 86%. Carbon dioxide was captured in the form of Li2CO3, with a capacity of 595 g of CO2 for1 kg of Li2CO3. The technology provides a sustainable and cost‐effective path for producing battery‐grade Li2CO3 from the lake brine.