bluuebunny/crossref_metadata_2025_split huggingface dataset:
Optimisation of perioperative investigations among elective orthopaedic patients in a Dublin-based teaching hospital
Authors: O’Sullivan Jane , Collins Jack , Cooper David , Magdalina Ana , Meehan Frances , Kumar Lachmann , Quinlan John , O’Connor Donal , Fitzpatrick Gerry 
Published: December 2018

Background The current National Institute for Health and Care Excellence guidelines, in accordance with the Association of Anaesthetists of Great Britain and Ireland guidelines, recommend the following haematological investigations for all patients undergoing major elective surgery: full blood count, renal profile and coagulation screen if clinically indicated. However, the guidelines fail to specify a time-interval for which normal blood results remain valid. Currently all patients in Ireland undergoing substantial elective surgery requiring general or regional anaesthetic have a preoperative assessment prior to the surgery. Patients have phlebotomy performed as part of this assessment. Patients admitted for elective surgery often have these bloods repeated on the morning of surgery. Objectives To determine if blood investigations taken over a one-year period prior to surgery can be used as a baseline for clinically stable patients undergoing elective surgery. Study design and methods All consecutive day of surgery admission patients >18 years of age undergoing elective orthopaedic surgery in Tallaght Hospital between 1 December 2014 and 1 December 2015 were identified using hospital records. Their blood results in the one-year period prior to surgery were compared to the blood results on the morning of surgery, using a McNemar’s test. A further clinical analysis was performed. Results There was no statistically significant change between blood results from three months prior to the surgery and the morning of surgery (P < 0.05). Furthermore, the blood results remained largely unchanged in the one year prior to surgery. No patient had the operation deferred due to aberrant blood results, following previously normal results prior to surgery. The potential cost-saving of omitting bloods is enormous. Conclusions There appears to be neither a statistical nor clinical benefit to repeating blood tests on the morning of surgery, following normal bloods <3 months in a clinically stable individual.
Accidental Finding of Atherosclerosis with 90% Stenosis of the Coronary Artery In a 17-Year-Old White Male
Authors: Bao Connie , Dilks Lindsay C. , Flessner Richard , Bao Shiping 
Published: December 2018

Atherosclerotic cardiovascular disease is the leading cause of death in the United States, though no case reports of teenage deaths due to the disease were found after extensive literary research. A case is presented of a 17-year-old male driver involved in a motor vehicle collision. Autopsy examination revealed multiple blunt force injuries. Approximately 3 mm of the middle portion of the left anterior descending coronary artery displayed about 90% atherosclerotic stenosis. It was determined that the cause of death was ventricular fibrillation due to atherosclerotic cardiovascular disease. The consultation with the parents and possible finding of hypercholesterolemia are discussed in the report.
A multimodal approach to the treatment of extensive burn scars: a modified subcision technique for intralesional delivery of corticosteroid and 5-fluorouracil in combination with several procedural laser therapies; a case report
Authors: Erickson Taylor , Gray Jayla , Tayebi Bailey , Tung Rebecca 
Published: December 2018

Introduction: Hypertrophic scars and keloids are challenging to manage due to recurrence and often sub-optimal response to treatment. There is a lack of both definitive treatment standards and randomised controlled trials comparing therapeutic options. While a wide array of procedures has been utilised to improve traumatic burn scars, such interventions have been used with varying degrees of success. Some reported methods include intralesional injections of anti-inflammatory and anti-mitotic medications, laser-based therapy, topical therapies, cryotherapy, silicone gel sheeting, pressure therapy, radiotherapy and reconstructive surgery. Case: We report a case of extensive traumatic burn scarring on the head and neck successfully treated with a multimodal approach comprised of an infrequently used modified subcision technique to deliver alternating intralesional injections of anti-inflammatory (high-dose steroid) and anti-metabolite (5-flurouracil) concurrently with a series of laser (epilatory, vascular and fractional) treatments. Methods: Our treatment modality utilised a subcisional technique to deliver intralesional steroid and anti-metabolite medications directly into scar tissue to downregulate inflammation and inhibit collagen synthesis. Alexandrite, fractional and pulsed dye laser therapy was employed to improve skin texture, reduce dyschromia and reduce tissue burden of hypertrophic scar and keloid tissue, resulting in improved mobility and skin elasticity. Conclusion: Our case supports a combined medical and procedural, subcisional, approach to successfully treat a patient with extensive hypertrophic scarring and keloid formation with associated hair entrapment after a head and neck burn.
The mutational landscape of Burkitt-like lymphoma with 11q aberration is distinct from that of Burkitt lymphoma
Authors: Wagener Rabea , Seufert Julian , Raimondi Francesco , Bens Susanne , Kleinheinz Kortine , Nagel Inga , Altmüller Janine , Thiele Holger , Hübschmann Daniel , Kohler Christian W. , Nürnberg Peter , Au-Yeung Rex , Burkhardt Birgit , Horn Heike , Leoncini Lorenzo , Jaffe Elaine S. , Ott German , Rymkiewicz Grzegorz , Schlesner Matthias , Russell Robert B. , Klapper Wolfram , Siebert Reiner 
Published: December 2018

Abstract
The new recently described provisional lymphoma category Burkitt-like lymphoma with 11q aberration comprises cases similar to Burkitt lymphoma (BL) on morphological, immunophenotypic and gene-expression levels but lacking the IG-MYC translocation. They are characterized by a peculiar imbalance pattern on chromosome 11, but the landscape of mutations is not yet described. Thus, we investigated 15 MYC-negative Burkitt-like lymphoma with 11q aberration (mnBLL,11q,) cases by copy-number analysis and whole-exome sequencing. We refined the regions of 11q imbalance and identified the INO80 complex-associated gene NFRKB as a positional candidate in 11q24.3. Next to recurrent gains in 12q13.11-q24.32 and 7q34-qter as well as losses in 13q32.3-q34, we identified 47 genes recurrently affected by protein-changing mutations (each ≥3 of 15 cases). Strikingly, we did not detect recurrent mutations in genes of the ID3-TCF3 axis or the SWI/SNF complex that are frequently altered in BL, or in genes frequently mutated in germinal center–derived B-cell lymphomas like KMT2D or CREBBP. An exception is GNA13, which was mutated in 7 of 15 cases. We conclude that the genomic landscape of mnBLL,11q, differs from that of BL both at the chromosomal and mutational levels. Our findings implicate that mnBLL,11q, is a lymphoma category distinct from BL at the molecular level.
The use of chest magnetic resonance imaging in interstitial lung disease: a systematic review
Authors: Romei Chiara , Turturici Laura , Tavanti Laura , Miedema Jelle , Fiorini Sara , Marletta Massimo , Wielopolski Piotr , Tiddens Harm , Falaschi Fabio , Ciet Pierluigi 
Published: December 2018

Thin-slices multi-detector computed tomography (MDCT) plays a key role in the differential diagnosis of interstitial lung disease (ILD). However, thin-slices MDCT has a limited ability to detect active inflammation, which is an important target of newly developed ILD drug therapy. Magnetic resonance imaging (MRI), thanks to its multi-parameter capability, provides better tissue characterisation than thin-slices MDCT.Our aim was to summarise the current status of MRI applications in ILD and to propose an ILD-MRI protocol. A systematic literature search was conducted for relevant studies on chest MRI in patients with ILD.We retrieved 1246 papers of which 55 original papers were selected for the review. We identified 24 studies comparing image quality of thin-slices MDCT and MRI using several MRI sequences. These studies described new MRI sequences to assess ILD parenchymal abnormalities, such as honeycombing, reticulation and ground-glass opacity. Thin-slices MDCT remains superior to MRI for morphological imaging. However, recent studies with ultra-short echo-time MRI showed image quality comparable to thin-slices MDCT. Several studies demonstrated the added value of chest MRI by using functional imaging, especially to detect and quantify inflammatory changes.We concluded that chest MRI could play a role in ILD patients to differentiate inflammatory and fibrotic changes and to assess efficacy of new ILD drugs.
Near-surface site investigation by seismic interferometry using urban traffic noise in Singapore
Authors: Zhang Yunhuo , Li Yunyue Elita , Zhang Heng , Ku Taeseo 
Published: December 2018

We have evaluated a field test in the city of Singapore to assess the feasibility of the passive seismic survey for bedrock depth determination and to further investigate the optimal acquisition parameters. The ambient noise field, dominated by urban traffic noise, is recorded passively for the application of seismic interferometry. Spectral analysis indicates that the traffic-induced noise by local roads is concentrated between 3 and 25 Hz. We use multiple signal classification beamforming for wavefield direction of propagation analysis. We apply seismic interferometry to retrieve the surface-wave part of the Green’s functions, based on which surface-wave dispersion relations are extracted and further inverted for 1D S-wave velocity profiles. Subsequently, we compare the inversion results from seismic interferometry with borehole logs at multiple sites in Singapore and establish that the bedrock depths are well-determined using passive seismic methods within a maximum error of 3 m. By investigating the convergence of the crosscorrelograms, we ascertain that the best compromise of cost, efficiency, and accuracy for a passive site investigation in Singapore can be achieved in 15 min in the morning of a working day using an array as short as 30 m with six vertical geophones, although these parameters should be reinvestigated at other sites and other times. The success of this case study demonstrates that accurate near-surface site investigation can be achieved with faster acquisition, fewer receivers, and a smaller acquisition footprint compared with conventional methods, all of which improve the efficiency particularly in a highly developed urban environment.
Health Related Quality of Life (HRQOL) and its correlation with academic performance of medical students
Authors: Sarwar Shahid , Aleem Abdul , Nadeem Muhammad Arif 
Published: December 2018

Objective: To determine health related quality of life (HRQOL) of medical students and its correlation with their academic performance.
Methods: Cross sectional study at Services Institute of Medical Sciences, included students of 4th and final year MBBS, who filled SF-36 proforma of HRQOL. Scores of 8-domains and of physical component and mental component summary were determined. Marks in all professional examinations were used to stratify students as high performers (≥ 70% marks) and average performing students (< 70%). HRQOL scores was correlated with academic performance using unpaired student’s t-test.
Results: Among 267 students included, mental health score (56.2±21.3) was lower than physical health component score (69.03±18.5). Role limitation due to emotional health (RE) (44.81), Vitality (VT) (54.19) and general health perception (GH) (58.89) had lower scores among 8domains of questionnaire. Female students had significantly lower scores in role limitation due to emotional problems (p value <0.04), vitality (<0.05), bodily pain (p value <0.05) and general health perception (p value<0.03) than male students. Physical health and role limitation due to physical health domains were better in high performing students.
Conclusion: Mental health of medical students is suboptimal, especially among female students. Students with better physical health have better academic performance.
How to cite this:Sarwar S, Aleem A, Nadeem MA. Health Related Quality of Life (HRQOL) and its correlation with academic performance of medical students. Pak J Med Sci. 2019;35(1):266-270. doi: https://doi.org/10.12669/pjms.35.1.147
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Comparison of mean pain scores for the patients with sub hepatic drainage to those without it after elective uncomplicated laparoscopic cholecystectomy
Authors: Nadeem Faisal , Khan Muhammad , Naz Faheem Ullah 
Published: December 2018

Objective: The sub hepatic drain is often placed after laparoscopic cholecystectomy is considered to affect post operative infection, pain and sub hepatic collections. The objective of this study was to compare the degree of postoperative pain in patients with routine drainage with those without it after elective, uncomplicated laparoscopic cholecystectomy.
Methods: This randomized control trial (RCT) was done over six months from 9th June 2015 to 8th December 2015 at Military Hospital Rawalpindi. Sample calculated with WHO calculator and consecutive non probability random sampling used to divide 170 patients undergoing laparoscopic cholecystectomy in two groups. One group had routine sub hepatic drain and other didn’t. Degree of postoperative pain was assessed according to VISUAL ANALOGUE SCALE by duty doctor at 24 hours. Data was collected and analyzed applying chi square test and p value was <0.05 considered statistically significant.
Results: Our results demonstrated that intensity of post operative pain in routine drainage group is higher as compared to non drainage group after elective, uncomplicated laparoscopic cholecystectomy.
Conclusion: Routine placement of sub hepatic drain in elective uncomplicated laparoscopic cholecystectomy should be avoided to reduce post-operative pain.
How to cite this:Nadeem F, Khan MR, Naz FU. Comparison of mean pain scores for the patients with sub hepatic drainage to those without it after elective uncomplicated laparoscopic cholecystectomy. Pak J Med Sci. 2019;35(1):226-229. doi: https://doi.org/10.12669/pjms.35.1.224
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Is there a relationship between serum vaspin levels and insulin resistance in chronic renal failure?
Authors: Demir Can , Dogantekin Akif , Gurel Ali , Aydin Suleyman , Celiker Huseyin 
Published: December 2018

Objective: Chronic kidney disease (CKD) patients have insulin secretion disorders and resistance to insulin effects, that is responsible for the development of cardiovascular events. Vaspin is an adipocytokine that regulates glucose and lipid metabolism. We aimed to determine the serum vaspin levels and its relationship with insulin resistance in CKD patients.
Methods: In the study groups, serum vaspin levels, anthropometric parameters and routine blood tests were measured. The serum vaspin levels were examined by the enzyme-linked immunosorbent assay (ELISA) and insulin resistance was determined by the homeostasis model assessment of insulin resistance (HOMA-IR) formula.
Results: The serum vaspin, HOMA-IR index and insulin levels were observed significantly high in the CKD group in comparison with the control group. No correlation was found between the serum vaspin level and the anthropometric and metabolic values. The serum vaspin level was positively correlated with the fasting plasma glucose and age but without statistical significance.
Conclusion: Insulin resistance and hyperinsulinemia contribute to the development of cardiovascular complications in CKD. We consider that the increase in the serum vaspin level is a consequence of the reduced renal excretion in the CKD and increases in response to insulin resistance.
How to cite this:Demir C, Dogantekin A, Gurel A, Aydin S, Celiker H. Is there a relationship between serum vaspin levels and insulin resistance in chronic renal failure? Pak J Med Sci. 2019;35(1):230-235. doi: https://doi.org/10.12669/pjms.35.1.96
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Who Wants Consumers to Be Informed? Facilitating Information Disclosure in a Distribution Channel
Authors: Hao Lin , Tan Yong 
Published: December 2018

We investigate a retailer’s and a supplier’s incentive to facilitate information disclosure, i.e., consumer learning of their true product valuation, under two popular supply chain contracts, i.e., the agency pricing model and the wholesale pricing model. Our results show that when a product has medium or high dispersion in its consumers’ true valuation distribution and the degree of information disclosure before facilitation is moderate, two parties might have opposing interests as to more information disclosure. Specifically, in the agency pricing model, the revenue sharing mechanism leads the supplier to benefit, but the retailer to suffer, from more information disclosure. In the wholesale model, potential misalignment of interests as to more information disclosure disappears if the demand is linear. Double marginalization absorbs influence of two parties’ marginal cost discrepancy and eventually tunes the two parties’ margin proportional to each other. If the demand is log-concave and derived from common valuation distributions such as normal or logistic distributions, misalignment reappears in the wholesale model, but interestingly, the retailer benefits and the supplier suffers from more disclosure, which is opposite to the misalignment result in the agency model under the same log-concave demand. Our results suggest that information disclosure facilitation has a different interplay with the revenue sharing mechanism in the agency model than with double marginalization in the wholesale model. The online appendix is available at https://doi.org/10.1287/isre.2017.0770 .
Screw head plugs increase the fatigue strength of stainless steel, but not of titanium, locking plates
Authors: Hung L-W. , Chao C-K. , Huang J-R. , Lin J. 
Published: December 2018

Objectives Screw plugs have been reported to increase the fatigue strength of stainless steel locking plates. The objective of this study was to examine and compare this effect between stainless steel and titanium locking plates. Methods Custom-designed locking plates with identical structures were fabricated from stainless steel and a titanium alloy. Three types of plates were compared: type I unplugged plates; type II plugged plates with a 4 Nm torque; and type III plugged plates with a 12 Nm torque. The stiffness, yield strength, and fatigue strength of the plates were investigated through a four-point bending test. Failure analyses were performed subsequently. Results For stainless steel, type II and type III plates had significantly higher fatigue strength than type I plates. For titanium, there were no significant differences between the fatigue strengths of the three types of plates. Failure analyses showed local plastic deformations at the threads of screw plugs in type II and type III stainless steel plates but not in titanium plates. Conclusion The screw plugs could increase the fatigue strength of stainless steel plates but not of titanium plates. Therefore, leaving screw holes open around fracture sites is recommended in titanium plates. Cite this article: L-W. Hung, C-K. Chao, J-R. Huang, J. Lin. Screw head plugs increase the fatigue strength of stainless steel, but not of titanium, locking plates. Bone Joint Res 2018;7:629–635. DOI: 10.1302/2046-3758.712.BJR-2018-0083.R1.
Management of symptomatic degenerative low-grade lumbar spondylolisthesis
Authors: Evans Nick , McCarthy Michael 
Published: December 2018

Degenerative low-grade lumbar spondylolisthesis is the most common form of spondylolisthesis. The majority of patients are asymptomatic and do not require surgical intervention. Symptomatic patients present with a combination of lower back pain, radiculopathy and/or neurogenic claudication and may warrant surgery if non-operative measures fail. There is widespread controversy regarding the indications for surgery and appropriate treatment strategies for patients with this type of spondylolisthesis. This article provides a comprehensive evidence-based review of the available literature to support the management of degenerative low-grade spondylolisthesis. Cite this article: EFORT Open Rev 2018;3:620-631. DOI: 10.1302/2058-5241.3.180020.
Creativity in Cantonese operatic singing: Analysis of excerpts from Hu Bu Gui by three artists as examples
Authors: Leung Bo-Wah 
Published: December 2018

Abstract
Cantonese opera is one of the most representative traditional art forms in Hong Kong; since the nineteenth century, numerous artists have established their own personal singing styles. Similarly, audiences have been enchanted with the art form’s creativity. However, in recent years, artists in Hong Kong have tended to merely imitate their predecessors, rather than striving to develop their own styles. This study aims to explore the attributes leading to the establishment of personal style. It firstly reviews literature about creativity in psychology as well as socio-historical phenomenon of Cantonese opera in Hong Kong, followed by an analysis of two Aria Type excerpts sung by three eminent artists, in order to explore the creative elements of some well-established personal styles. Findings suggest that a keen competitive environment among artists with a knowledgeable and demanding audience may help artists to determine in striving for development of personal styles, which is, in essence, ‘imitation with flexibility’.
A content analysis of the International Journal of Community Music, 2008–18
Authors: Rohwer Debbie Ann 
Published: December 2018

Abstract
The purpose of the current content analysis was to describe the publication characteristics found in the International Journal of Community Music from the first print issue in 2008 through 2018. Across the ten years, each of the 30 issues were coded for page length, types of articles, editorials, review board characteristics, single- and co-authored article details, repeat authors and author countries. Results showed that approximately half of the articles were research, with qualitative studies being the most common. Exemplars and position papers were the most common non-research articles. Adults were the most common age level addressed. Approximately three-quarters of the articles were single-authored and the United States was the most common country of publications. Conclusions address the strengths of the journal and future directions for community music writings, including expansion of topics, areas and article formats.