bluuebunny/crossref_metadata_2025_split huggingface dataset:
Transplant strategies in relapsed/refractory Hodgkin lymphoma
Authors: Shah Gunjan L. , Moskowitz Craig H. 
Published: March 2018

AbstractThe majority of patients with Hodgkin lymphoma (HL) are cured with initial therapy. However, high-dose therapy with autologous hematopoietic cell transplant (AHCT) allows for the cure of an additional portion of patients with relapsed or primary refractory disease. Positron emission tomography–negative complete remission before AHCT is critical for long-term disease control. Several salvage options are available with comparable response rates, and the choice can be dependent of comorbidities and logistics. Radiation therapy can also improve the remission rate and is an important therapeutic option for selected patients. Brentuximab vedotin (BV) maintenance after AHCT is beneficial in patients at high risk for relapse, especially those with more than 1 risk factor, but can have the possibility of significant side effects, primarily neuropathy. Newer agents with novel mechanisms of action are under investigation to improve response rates for patients with subsequent relapse, although are not curative alone. BV and the checkpoint inhibitors nivolumab and pembrolizumab are very effective with limited side effects and can bridge patients to curative allogeneic transplants (allo-HCT). Consideration for immune-mediated toxicities, timing of allogeneic hematopoietic cell transplant based on response, and the potential for increased graft-versus-host disease remain important. Overall, prospective investigations continue to improve outcomes and minimize toxicity for relapsed or primary refractory HL patients.
Management of relapsed/refractory classical Hodgkin lymphoma in transplant-ineligible patients
Authors: Mehta-Shah Neha , Bartlett Nancy L. 
Published: March 2018

AbstractAddition of brentuximab vedotin, a CD30-targeted antibody–drug conjugate, and the programmed death 1 (PD-1) inhibitors nivolumab and pembrolizumab to the armamentarium for transplant-ineligible relapsed/refractory classical Hodgkin lymphoma has resulted in improved outcomes, including the potential for cure in a small minority of patients. For patients who have failed prior transplant or are unsuitable for dose-intense approaches based on age or comorbidities, an individualized approach with sequential use of single agents such as brentuximab vedotin, PD-1 inhibitors, everolimus, lenalidomide, or conventional agents such as gemcitabine or vinorelbine may result in prolonged survival with a minimal or modest effect on quality of life. Participation in clinical trials evaluating new approaches such as combination immune checkpoint inhibition, novel antibody–drug conjugates, or cellular therapies such as Epstein-Barr virus–directed cytotoxic T lymphocytes and chimeric antigen receptor T cells offer additional options for eligible patients.
Balancing risk and benefit in early-stage classical Hodgkin lymphoma
Authors: Bröckelmann Paul J. , Sasse Stephanie , Engert Andreas 
Published: March 2018

Abstract
With defined chemotherapy and radiotherapy (RT) and risk-adapted treatment, early-stage classical Hodgkin lymphoma (HL) has become curable in a majority of patients. Hence, a major current goal is to reduce treatment-related toxicity while maintaining long-term disease control. Patients with early-stage favorable disease (ie, limited stage without risk factors [RFs]) are frequently treated with 2 cycles of doxorubicin, bleomycin, vinblastine, and dacarbazine (2×ABVD) followed by 20-Gy involved-field or involved-site RT (IF/ISRT). In patients with early-stage unfavorable disease (ie, limited stage with RFs), 4 cycles of chemotherapy are usually consolidated with 30-Gy IF/ISRT. Compared with 4×ABVD, 2 cycles of bleomycin, etoposide, doxorubicin, cyclophosphamide, vincristine, procarbazine, and prednisone (2×BEACOPPescalated) followed by 2×ABVD improved 5-year progression-free survival (PFS), with similar 5-year overall survival. Recently, treatment strategies based on [18F]fluorodeoxyglucose positron emission tomography (PET) response were evaluated. In early-stage unfavorable HL, a majority of patients achieved a negative interim PET after 2×ABVD and an excellent outcome after 4×ABVD, whereas in those with a positive interim PET, 2×BEACOPPescalated improved 5-year PFS. Furthermore, a PET-guided RT approach was evaluated to decrease long-term toxicity. Although both the RAPID and H10 trials reported poorer disease control without RT, PET-guided omission of RT can constitute a valid therapeutic option in patients with an increased risk of RT-associated toxicity (eg, because of sex, age, or disease localization). Implementation of drugs such as the anti-CD30 antibody-drug conjugate brentuximab vedotin or the anti–programmed death 1 antibodies nivolumab or pembrolizumab might allow further reduction of overall mortality and improve quality of life in affected patients.
Complete correction of hemophilia B phenotype by FIX-Padua skeletal muscle gene therapy in an inhibitor-prone dog model
Authors: French Robert A. , Samelson-Jones Benjamin J. , Niemeyer Glenn P. , Lothrop Clinton D. , Merricks Elizabeth P. , Nichols Timothy C. , Arruda Valder R. 
Published: March 2018

Key Points
Skeletal muscle–directed expression of FIX-Padua resulted in complete correction of HB phenotype in an inhibitor-prone dog model. Long-term immune tolerance to FIX is sustained over years upon multiple challenges with recombinant FIX protein in 2 HB models.
CSF1R inhibition prevents radiation pulmonary fibrosis by depletion of interstitial macrophages
Authors: Meziani Lydia , Mondini Michele , Petit Benoît , Boissonnas Alexandre , Thomas de Montpreville Vincent , Mercier Olaf , Vozenin Marie-Catherine , Deutsch Eric 
Published: March 2018

Radiation-induced lung fibrosis (RIF) is a delayed side-effect of chest radiotherapy, frequently associated with macrophage infiltration.We aimed to characterise the role of pulmonary macrophages in RIF using human lung biopsies from patients receiving radiotherapy for thorax malignancies and a RIF model developed in C57BL/6 mice after 16-Gy thorax irradiation.High numbers of macrophages (both interstitial and alveolar) were detected in clinical and preclinical RIF. In the preclinical model, upregulation of T-helper (Th)2 cytokines was measured, whereas Th1 cytokines were downregulated in RIF tissue lysate. Bronchoalveolar lavage demonstrated upregulation of both types of cytokines. At steady state, tissue-infiltrating macrophages (IMs) expressed 10-fold more arginase (Arg)-1 than alveolar macrophages (AMs), and a 40-fold upregulation of Arg-1 was found in IMs isolated from RIF. IMs, but not AMs, were able to induce myofibroblast activationin vitro. In addition, whereas depletion of AMs using Clodrosome didn't affect RIF score, depletion of IMs using a clinically available colony-stimulating factor receptor-1 (CSF1R) neutralising antibody was antifibrotic.These findings suggest differential contributions of alveolarversusinterstitial macrophages in RIF, highlighting the fibrogenic role of IMs. The CSF1/CSF1R pathway was identified as a new therapeutic target to inhibit RIF.
Observing dyspnoea in others elicits dyspnoea, negative affect and brain responses
Authors: Herzog Michaela , Sucec Josef , Van Diest Ilse , Van den Bergh Omer , Chenivesse Cecile , Davenport Paul , Similowski Thomas , von Leupoldt Andreas 
Published: March 2018

Dyspnoea is usually caused by diagnosable cardiorespiratory mechanisms. However, frequently dyspnoea relates only weakly or not at all to cardiorespiratory functioning, suggesting that additional neuropsychosocial processes contribute to its experience. We tested whether the mere observation of dyspnoea in others constitutes such a process and would elicit dyspnoea, negative affect and increased brain responses in the observer.In three studies, series of pictures and videos were presented, which either depicted persons suffering from dyspnoea or nondyspnoeic control stimuli. Self-reports of dyspnoea and affective state were obtained in all studies. Additionally, respiratory variables and brain responses during picture viewing (late positive potentials in electroencephalograms) were measured in one study.In all studies, dyspnoea-related pictures and videos elicited mild-to-moderate dyspnoea and increased negative affect compared to control stimuli. This was paralleled by increased late positive potentials for dyspnoea-related pictures while respiratory variables did not change. Moreover, increased dyspnoea correlated modestly with higher levels of empathy in observers.The present results demonstrate that observing dyspnoea in others elicits mild-to-moderate dyspnoea, negative affect, and increased brain responses in the absence of respiratory changes. This vicarious dyspnoea has clinical relevance, as it might increase suffering in the family and medical caregivers of dyspnoeic patients.
Validation of the Orebro musculoskeletal pain screening questionnaire in patients with chronic neck pain
Authors: Langenfeld Anke , Bastiaenen Carolien , Brunner Florian , Swanenburg Jaap 
Published: March 2018

Abstract
Objectives
To validate the German version of OMPSQ (OMPSQ-G) for patients with chronic neck pain.

Results
After translating OMPSQ to German, we assessed the discriminant validity between patients and healthy adults. Convergent validity was assessed using Pearson’s correlation coefficients between domains of OMPSQ-G and the German version of neck disability index (NDI-G) and visual analogue scale (VAS) of neck pain intensity. Floor and ceiling effects, internal consistency, test–retest and relative reliability were assessed. Fifty patients with chronic neck pain (mean age, 43.6 years; 34 females) and 24 healthy adults (mean age, 50.4 years; 18 females) participated. Mann–Whitney U tests showed significant differences in OMPSQ scores between both groups at the baseline (z = − 4.6; p < 0.001) and second time point (z = − 4.8; p < 0.001). OMPSQ-G scores highly and moderately correlated with NDI-G (ρ = 0.70) and VAS (ρ = 0.41) scores, respectively. There were no floor or ceiling effects. Cronbach’s alpha was 0.94. OMPSQ-G showed high reliability (intraclass correlation 2.1: 0.93; standard error of measurement, 6.9; smallest detectable change, 20 points). The Bland–Altman plot indicated no systematic error. OMPSQ-G showed good validity and reliability in patients with neck pain.
Trial registration NCT02540343
An exploratory study on up-cycling as the sustainable clothing life at home
Authors: Shim Sooyoen , Kim Jisoo , Na Youngjoo 
Published: March 2018

AbstractThe textile and fashion industries are difficult to achieve sustainability because they are made up of long supply chains. Also, it cannot rely only on the industries for sustainable. Thus, it is important that consumers have to practice at home. Therefore, it is necessary to give the ideas that can be done at home, promote the importance of practice, and present a variety of practical ways. We executed focus-group interview to understand sustainable clothing and the attitude and status of up-cycling in families. Situation analysis for the attitude and up-cycling of sustainable clothing is available with various participants in each group upon fluency of up-cycling method, information share ability, and the degree of understanding in clothing-fiber production process. It showed that they make selective purchase of sustainable fashion products in families, washing and control for minimizing of environmental impact and energy consumption, and recycling and used articles trade, a way of life for sustainable clothing.
Dasatinib in Pediatric Patients With Chronic Myeloid Leukemia in Chronic Phase: Results From a Phase II Trial
Authors: Gore Lia , Kearns Pamela R. , de Martino Maria Lucia , Lee  , De Souza Carmino Antonio , Bertrand Yves , Hijiya Nobuko , Stork Linda C. , Chung Nack-Gyun , Cardos Rocio Cardenas , Saikia Tapan , Fagioli Franca , Seo Jong Jin , Landman-Parker Judith , Lancaster Donna , Place Andrew E. , Rabin Karen R. , Sacchi Mariana , Swanink Rene , Zwaan C. Michel 
Published: March 2018

PurposeSafe, effective treatments are needed for pediatric patients with chronic myeloid leukemia in chronic phase (CML-CP). Dasatinib is approved for treatment of adults and children with CML-CP. A phase I study determined suitable dosing for children with Philadelphia chromosome–positive (Ph+) leukemias.MethodsCA180-226/NCT00777036 is a phase II, open-label, nonrandomized prospective trial of patients < 18 years of age receiving dasatinib. There are three cohorts: (1) imatinib-resistant/intolerant CML-CP, (2) imatinib-resistant/intolerant CML in accelerated/blast phase or Ph+ acute lymphoblastic leukemia (n = 17), and (3) newly diagnosed CML-CP treated with tablets or powder for oral suspension. Major cytogenetic response > 30% for imatinib-resistant/intolerant patients and complete cytogenetic response (CCyR) > 55% for newly diagnosed patients were of clinical interest.ResultsOf 113 patients with CML-CP, 14 (48%) who were imatinib-resistant/intolerant and 61 (73%) who were newly diagnosed remained on treatment at time of analysis. Major cytogenetic response > 30% was reached by 3 months in the imatinib-resistant/intolerant group and CCyR > 55% was reached by 6 months in the newly diagnosed CML-CP group. CCyR and major molecular response by 12 months, respectively, were 76% and 41% in the imatinib-resistant/intolerant group and 92% and 52% in newly diagnosed CML-CP group. Progression-free survival by 48 months was 78% and 93% in the imatinib-resistant/intolerant and newly diagnosed CML-CP groups, respectively. No dasatinib-related pleural or pericardial effusion, pulmonary edema, or pulmonary arterial hypertension were reported. Bone growth and development events were reported in 4% of patients.ConclusionIn the largest prospective trial to date in children with CML-CP, we demonstrate that dasatinib is a safe, effective treatment of pediatric CML-CP. Target responses to first- or second-line dasatinib were met early, and deep molecular responses were observed. Safety of dasatinib in pediatric patients was similar to that observed in adults; however, no cases of pleural or pericardial effusion or pulmonary arterial hypertension were reported.
Effects of Altering Levothyroxine (L-T4) Doses on Quality of Life, Mood, and Cognition in L-T4 Treated Subjects
Authors: Samuels Mary H , Kolobova Irina , Niederhausen Meike , Janowsky Jeri S , Schuff Kathryn G 
Published: March 2018

Abstract

Background
The brain is a critical target organ for thyroid hormone, but it is unclear whether variations in thyroid function within and near the reference range affect quality of life, mood, or cognition.

Methods
A total of 138 subjects with levothyroxine (L-T4)-treated hypothyroidism and normal thyrotropin (TSH) levels underwent measures of quality of life (36-Item Short Form Health Survey, Underactive Thyroid-Dependent Quality of Life Questionnaire), mood (Profile of Mood States, Affective Lability Scale), and cognition (executive function, memory). They were then randomly assigned to receive an unchanged, higher, or lower L-T4 dose in double-blind fashion, targeting one of three TSH ranges (0.34 to 2.50, 2.51 to 5.60, or 5.61 to 12.0 mU/L). Doses were adjusted every 6 weeks based on TSH levels. Baseline measures were reassessed at 6 months.

Results
At the end of the study, by intention to treat, mean L-T4 doses were 1.50 ± 0.07, 1.32 ± 0.07, and 0.78 ± 0.08 μg/kg (P &lt; 0.001), and mean TSH levels were 1.85 ± 0.25, 3.93 ± 0.38, and 9.49 ± 0.80 mU/L (P &lt; 0.001), respectively, in the three arms. There were minor differences in a few outcomes between the three arms, which were no longer significant after correction for multiple comparisons. Subjects could not ascertain how their L-T4 doses had been adjusted (P = 0.55) but preferred L-T4 doses they perceived to be higher (P &lt; 0.001).

Conclusions
Altering L-T4 doses in hypothyroid subjects to vary TSH levels in and near the reference range does not affect quality of life, mood, or cognition. L-T4-treated subjects prefer perceived higher L-T4 doses despite a lack of objective benefit. Adjusting L-T4 doses in hypothyroid patients based on symptoms in these areas may not result in significant clinical improvement.
Comparing organic versus conventional soil management on soil respiration
Authors: Mátyás Bence , Chiluisa Andrade Maritza Elizabeth , Yandun Chida Nora Carmen , Taipe Velasco Carina Maribel , Gavilanes Morales Denisse Estefania , Miño Montero Gisella Nicole , Ramirez Cando Lenin Javier , Lizano Acevedo Ronnie Xavier 
Published: March 2018

Soil management has great potential to affect soil respiration. In this study, we investigated the effects of organic versus conventional soil management on soil respiration. We measured the main soil physical-chemical properties from conventional and organic managed soil in Ecuador. Soil respiration was determined using alkaline absorption according to Witkamp. Soil properties such as organic matter, nitrogen, and humidity, were comparable between conventional and organic soils in the present study, and in a further analysis there was no statically significant correlation with soil respiration. Therefore, even though organic farmers tend to apply more organic material to their fields, but this did not result in a significantly higher CO2 production in their soils in the present study.
Reliability of unconventional torso anthropometry using a three-dimensional scanner in Peruvian children and adolescents
Authors: Delgado Carlos Alberto , Shimabuku Roberto , Alarcón Erika , Huicho Luis , De Moraes Augusto Cesar Ferreira ,   SAYCARE Study Group
Published: March 2018

Background: Three-dimensional (3D) scanners have made it possible to measure and display body surface and shape with high precision. These are fast measurements with minimum discomfort, which is especially useful when children are involved. The objective was to assess the reliability and validity of a 3D-scanner for measuring unconventional torso parameters in children and adolescents. Methods: This is a sub-sample of the SAYCARE study, an observational multicentre research effort being conducted in six South American countries, aimed at developing methods to collect data on cardiovascular health biomarkers, lifestyles, and environmental, social and family risk factors. Images were captured using a portable scanner (iSense, Cubify, USA) attached to a Tablet 128Gb with OSX (Ipad-Air Apple, USA). Images were reshaped to exclude head, hair, arms and legs; area and volume were measured using 3D design software ((Rhinoceros for OSX, v5.02, USA). Results: The sub-sample for our study comprised 54 girls and 46 boys, aged 6 to 17 years old, from two private schools in Lima, Peru. Out of 100 participants, 82 were scanned twice. There was strong reliability (rho_c> 0.80) between first and second measurements of area and volume in boys of every age group. In girls, the reliability coefficient was moderate (rho_c> 0.70) only for area comparison in adolescents older than 10 years of age. The mean torso area was 0.55 m2 (SD 0.08) in girls and 0.63 m2 (SD 0.13) in boys. The overall mean torso volume was 24.4 l (SD 5.33) in girls and 31.47 l (SD 10.14) in boys. Area under ROC curve oscillates between 0.5707 and 0.6383 when volume/area ratio was compared to the selected “gold standard” (waist to height ratio > 0.5). Conclusion: Use of portable and low cost 3D-scanners provides a reliable but inaccurate alternative for area and volume torso measurements in children and adolescents.
Gene Unprediction with Spurio: A tool to identify spurious protein sequences
Authors: Höps Wolfram , Jeffryes Matt , Bateman Alex 
Published: March 2018

We now have access to the sequences of tens of millions of proteins. These protein sequences are essential for modern molecular biology and computational biology. The vast majority of protein sequences are derived from gene prediction tools and have no experimental supporting evidence for their translation. Despite the increasing accuracy of gene prediction tools there likely exists a large number of spurious protein predictions in the sequence databases. We have developed the Spurio tool to help identify spurious protein predictions in prokaryotes. Spurio searches the query protein sequence against a prokaryotic nucleotide database using tblastn and identifies homologous sequences. The tblastn matches are used to score the query sequence’s likelihood of being a spurious protein prediction using a Gaussian process model. The most informative feature is the appearance of stop codons within the presumed translation of homologous DNA sequences. Benchmarking shows that the Spurio tool is able to distinguish spurious from true proteins. However, transposon proteins are prone to be predicted as spurious because of the frequency of degraded homologs found in the DNA sequence databases. Our initial experiments suggest that less than 1% of the proteins in the UniProtKB sequence database are likely to be spurious and that Spurio is able to identify over 60 times more spurious proteins than the AntiFam resource. The Spurio software and source code is available under an MIT license at the following URL: https://bitbucket.org/bateman-group/spurio
Bricks-and-Mortar Entry by Online Retailers in the Presence of Consumer Sales Taxes
Authors: Arya Anil , Mittendorf Brian 
Published: March 2018

This paper presents a parsimonious model of the bricks-and-mortar entry choice of online retailers in light of consumer sales taxes. On the one hand, a retailer benefits by entry since the second distribution channel enables it to reach new customers, giving it a leg up on rivals. On the other hand, physical entry typically compels the retailer to start collecting sales taxes even for online transactions, making its consumers particularly price sensitive. This paper examines this trade-off to characterize a retailer’s entry decision, as well as the market-level equilibrium of bricks-and-mortar penetration. The paper then layers in supply market considerations—namely, the retailer’s procurement of products from upstream suppliers. The analysis demonstrates that sales taxes not only reduce the consumers’ willingness to pay for products in the retail market, but also dampen the retailer’s willingness to pay for the products in the wholesale arena. This reluctance influences the clearing price in the supply market and, thus, the firm’s decision to establish the physical retail store. This paper was accepted by Shivaram Rajgopal, accounting.
Identificatin and quantiative analysis of amyrins in Humulus lupulus L.
Authors: Rokicka Kamila , Wojciak-Kosior Magdalena 
Published: March 2018

ABSTRACT
In the paper, the identification and quantification of α- and β-amyrin in five varieties of Humulus lupulus is described. The plant samples were extracted with ethyl acetate and analyzed using of high performance liquid chromatography (HPLC) with PAD detection. The separation was achieved on RP 18 column, at 2 mL/min flow rate and at temperature of 35°C. Acetonitrile was used as a mobile phase. The established calibration curves and the other validation parameters: linearity (correlation coefficient r > 0.9988) and precision (RSD values ranged from 0.14 to 1.81%) were found to be satisfactory for the proposed method. The content of α- and β-amyrin strongly depended on varieties of H. lupulus and amounted from 72.7 to 232.5 μg/g and from 77.9 to 176.9 μg/g of dry plant material, respectively.