bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pancreatic cancer microenvironment: a current dilemma
Authors: Uzunparmak Burak , Sahin Ibrahim Halil 
Published: January 2019

AbstractPancreatic cancer is one of the leading causes of cancer‐related death in the United States and survival outcomes remain dismal despite significant advances in molecular diagnostics and therapeutics in clinical practice. The microenvironment of pancreatic cancer carries unique features with increased desmoplastic reaction and is infiltrated by regulatory T cells and myeloid‐derived suppressor cells which negatively impact the effector immune cells. Current evidence suggests that stellate cell‐induced hypovascular stroma may have direct effects on aggressive behavior of pancreatic cancer. Preclinical studies suggested improvement in drug delivery to cancer cells with stroma modifying agents. However these findings so far have not been confirmed in clinical trials. In this article, we elaborate current‐state‐of‐the science of the pancreatic cancer microenvironment and its impact on molecular behavior of cancer cells, chemotherapy resistance and druggability of stroma elements in combination with other agents to enhance the efficacy of therapeutic approaches.
Studies of the Optical and Sensing Properties of 1,3,5-Triazine-Cored Star-Shaped (D-π)3-A Molecules with Various Amino-Donor-Type Cation Receptors
Authors: Muraoka Hiroki , Sasaki Hikaru , Ogawa Satoshi 
Published: January 2019

Abstract
We newly designed and synthesized two kinds of 1,3,5-triazine-cored star-shaped (D-π)3-A molecules with 1-aza 15-crown 5-ether receptors (TSM-ACE) and dipicolylamino receptors (TSM-DPA), which possess an intramolecular charge transfer (ICT) nature and exhibit ICT-based optical properties (ICT transition absorption and fluorescence from a ICT excited state). Both TSM-ACE and TSM-DPA display proton-induced optical spectral blue-shifts followed by red-shifts depending on their inherent two-step protonation behavior. Furthermore, TSM-ACE displays optical spectral blue-shifts followed by red-shifts upon stepwise complexation of Mg2+, whereas TSM-DPA displays optical spectral blue-shifts upon the complexation of Zn2+. The cation sensing mechanism can be explained as follows: (i) the initial blue shift is caused by the decreased ICT donor abilities of three amino-donor-type receptors (a decrease of the ICT efficiency) upon binding cations, and (ii) the second red shift is caused by an increased acceptor ability of the 1,3,5-triazine core upon binding cations. Consequently, we revealed that TSM-ACE and TSM-DPA with different cation-recognition functionalities serve as a unique optical sensor capable of visual and distinct detection of not only protons but also different kinds of metal ions.
Case Report: Recurrent hypokalemic periodic paralysis associated with distal renal tubular acidosis (type 1) and hypothyroidism secondary to Hashimoto's thyroiditis
Authors: Meregildo-Rodríguez E. Dante , Failoc-Rojas Virgilio E. 
Published: January 2019

Background: Hypokalemic periodic paralysis (HypoKPP) is characterized by transient episodes of flaccid muscle weakness. We describe the case of a teenaged boy with HypoKPP and hyperthyroidism due to Hashimoto's thyroiditis with initial manifestation of renal tubular acidosis. This combination is rare and little described previously in men. Case presentation: A 17-year-old boy was admitted after three days of muscular weakness and paresthesia in the lower limbs with an ascending evolution, leading to prostration. Decreased strength was found in the lower limbs without a defined sensory level, reduced patellar and ankle reflexes. Positive antithyroid antibodies were found. He received hydration treatment, IV potassium and levothyroxine, with which there was a clinical improvement. Other examinations led to the diagnosis of type 1 renal tubular acidosis. Conclusion: HypoKPP is a rare disorder characterized by acute episodes of muscle weakness. Type 1 renal tubular acidosis can occur as a consequence of thyroiditis, which is explained by the loss of potassium. This combination is unusually rare, and has not been described before in men. The etiopathogenesis of the disease as well as a dynamic explanation of what happened with the patient are discussed in this report.
Factors associated with poor physical performance in older adults of 11 Peruvian high Andean communities
Authors: Urrunaga-Pastor Diego , Runzer-Colmenares Fernando M. , Arones Tania M. , Meza-Cordero Rosario , Taipe-Guizado Silvana , Guralnik Jack M. , Parodi Jose F. 
Published: January 2019

Background: Physical performance in the older adult has been extensively studied. However, only a few studies have evaluated physical performance among older adults of high Andean populations and none have studied the factors associated with it. The objective of this study was to evaluate factors associated with poor physical performance by using the Short Physical Performance Battery (SPPB) in older adults living in 11 Peruvian high Andean communities. Methods: An analytical cross-sectional study was carried out in inhabitants aged 60 or over from 11 high-altitude Andean communities of Peru during 2013-2017. Participants were categorized in two groups according to their SPPB score: poor physical performance (0-6 points) and medium/good physical performance (7-12 points). Additionally, we collected socio-demographic, medical, functional and cognitive assessment information. Poisson regression models were constructed to identify factors associated with poor physical performance. Prevalence ratio (PR) with 95% confidence intervals (95 CI%) are presented. Results: A total of 407 older adults were studied. The average age was 73.0 ± 6.9 years (range: 60-94 years) and 181 (44.5%) participants had poor physical performance (0-6 points). In the adjusted Poisson regression analysis, the factors associated with poor physical performance were: female gender (PR=1.29; 95%CI: 1.03-1.61), lack of social support (PR=2.10; 95%CI: 1.17-3.76), number of drugs used (PR=1.09; 95%CI: 1.01-1.17), urinary incontinence (PR=1.45; 95%CI: 1.16-1.82), exhaustion (PR=1.35; 95%CI: 1.03-1.75) and cognitive impairment (PR=1.89; 95%CI: 1.40-2.55). Conclusions: Almost half of the population evaluated had poor physical performance based on the SPPB. Factors that would increase the possibility of suffering from poor physical performance were: female gender, lack of social support, number of drugs used, urinary incontinence, exhaustion and cognitive impairment. Future studies with a larger sample and longitudinal follow-up are needed to design beneficial interventions for the high Andean population.
Avanti il divorzio e La mia vita
Authors: Gragnani Cristina 
Published: January 2019

Avanti il divorzio (1902) di Anna Franchi narra della vita di Anna Mirello dall’infanzia ‘libera e gagliarda’ (per dirla con le parole, più tarde, della Aleramo3), attraverso il suo matrimonio – sedicenne – con il musicista Ettore Streno, fino alla partenza del marito per gli Stati Uniti insieme ai figli. Romanziera, drammaturga, biografa, critica e storica d’arte, Anna Franchi nasce a Livorno nel 1867 e muore a Milano nel 1954. Gravitando attorno al Partito Socialista, si impegna per la campagna a favore di una legge sul divorzio con articoli e conferenze (oltre al romanzo Avanti il divorzio di cui mi occupo qui). Porta avanti su vari giornali un’azione di sensibilizzazione delle donne riguardo alla loro condizione e ruolo in società, con particola-re attenzione alla lotta per il suffragio La narrazione ripercorre le violenze inflitte ad Anna da Ettore (assalti sessuali, gravidanze indesiderate, aggressioni verbali, tradimenti, malattie veneree, false accuse, abusi sui figli e infine la sottrazione dei figli) e si ferma proprio nel 1902 – anno di pubblicazione del libro – con la rinuncia da parte di Anna alla lotta per la tutela dei ragazzi che rimangono, per legge, al marito depravato.
“Introduction” au numéro 10 de Mnemosyne
Authors: Barbalato Beatrice 
Published: January 2019

On lira dans ce numéro des études traitant de l’incidence de la catégorie temporelle sur les narrations autobiographiques. Il n’est rien qui articule plus que le temps la vision que nous donnons à notre existence. À travers les verbes, le choix d’une langue, l’organisation du discours, l’importance donnée à la présence ou à l’absence, au visible et à l’invisible, comme la mort, on voit le temps exercer son rôle de maître du jeu.
Plus rarement, l’espace apparaît comme le principe ordinateur d’un récit de vie. La culture occidentale est liée à une conception surtout chronologique, linéaire, même si écrivains, artistes, philosophes, principalement au 20e siècle, ont voulu contraster cette vision.
Chronos, kairos, aion, constituent les trois pivots qui depuis l’antiquité façonnent notre vision dans laquelle inscrire tout événement. À chaque pas nous nous rapportons à cet héritage.
Le travail de lecture des groupes de lecteurs des archives belges du patrimoine autobiographique
Authors: Meurice Francine 
Published: January 2019

Le travail de lecture, fourni par les groupes de lecteurs des archives belges du patrimoine autobiographique lors de la rédaction des échos de lecture convoque plusieurs stratégies d’interprétation. Il serait intéressant de repérer quels sont les modèles de lecture théoriques capables de décrire les stratégies le plus souvent sollicitées et ce, afin de cerner les compétences de ce lecteur qui est inscrit dans le dispositif communicationnel de l’APA comme c-énonciateur de ces écrits du « for-privé ». Ce co-énonciateur se profile aux côtés de l’énonciateur des écrits autobiographiques tantôt comme le guide de la construction de l’éthos, tantôt comme un actant rassemblant plusieurs forces lectrices, tantôt comme un témoin de la pratique scripturale à l’instar du lecteur postulé par la critique génétique, tantôt comme un lecteur intime. Quelques configurations discursives du fonds de l’APA seront proposées pour lire ce dialogue entre ces différentes figures.
À l’écoute du Perdu
Authors: Gauthier Patricia 
Published: January 2019

Dans Boutès, Quignard redit ses liens avec la musique. Boutès incarne l’élan vers la condition originaire que la musique, mieux que l’écriture (?), peut espérer faire retrouver parce que seule elle ‘replonge le corps dans le contenant sonore où il se mouvait’ avant la naissance [Boutès,p.65]. De fait, toute l’œuvre de Quignard retrace la quête de ce Perdu de laquelle s’élève un bios dont le biographique est partout et la biographie nulle part. L’impossibilité de cette autobiographie génériquement identifiée trouve peut-être une expression apaisée permettant de réconcilier musique et écriture dans la confession finale de Boutès.
Monocausale ou réticulaire?
Authors: Chehab May 
Published: January 2019

L’article étudie la représentation de l’hérédité dans Le Labyrinthe du monde de Marguerite Yourcenar, qui semble s’identifier à la fatalité (« Cette fillette vieille d’une heure est en tout cas déjà prise, comme dans un filet », Souvenirs pieux). C’est pour peser cette contingence que Yourcenar mène une longue enquête généalogique. Pourtant, elle n’est pas dupe de l’inanité de cette recherche (« il va sans dire que je n’ai pas trouvé les communs dénominateurs cherchés entre ces personnes et moi », ibid.).
C’est que Yourcenar oppose au poids de l’hérédité la légèreté du libre-arbitre : si l’homme ne peut se dérober à son destin, il peut du moins s’y soumettre avec ferveur, suivant l’injonction de Nietzsche. Ainsi, la modélisation traditionnelle de l’arbre généalogique, régie par un rapport déterministe et monocausal, cède le pas à une représentation réticulaire du diagramme généalogique, où les nœuds sont unis par la relation – dans les deux sens du terme – qui unit leurs membres.
Paul Léautaud, le destin comme accomplissement d’un demon
Authors: Denavarre Nicolas 
Published: January 2019

« Notre tempérament est notre maître » écrivait Paul Léautaud, retrouvant sans le savoir la maxime d'Héraclite selon laquelle « le tempérament de l'homme est son destin » (Ethos anthropo daimon). Le Daimon de Léautaud (1872-1956), on peut l'appeler « Maurice Boissard », du nom de ce personnage que l'écrivain s'était inventé à 30 ans pour signer ses chroniques dramatiques au Mercure de France, un vieillard narcissique, sarcastique, impitoyable, mélancolique et original préfigurant son propre devenir.
Effets d'annonces, intuitions prophétiques de ce « devenir Boissard », moments de révolte puis de résignations, résurgences d'autres moi possibles notés « dans un coin de journal », sont autant d'étapes consignées par le diariste et témoignant de ce processus implacable d'individuation de son Daimon par lequel Léautaud accomplit son propre destin.
Le désoubli de soi
Authors: Ouallet Yves 
Published: January 2019

Dans La Règle du jeu, Michel Leiris continue l’entreprise de connaissance de soi commencée dans L’Âge d’homme, afin d’accéder à un moi éthique. Les bifurcations, métamorphosées en biffures, deviennent les signes de cette libération de soi par l’écriture. Mais cette tentative échoue dans la transformation escomptée de soi. On ne se change pas soi-même en immergeant l’éthique dans l’écriture: tel est le destin d’une écriture de soi qui n’est pas une ascèse. Cependant, par l’acte d’écrire, l’écrivain dessine une identité différente de l’identité descriptive qui nous est assignée génétiquement et socialement, identité qui diffère également de l’identité narrative chère à Paul Ricoeur: on peut appeler identité poétique cette manière d’être en dehors de soi dans l’oeuvre créée - identité que la pratique poétique de l’écriture de soi rend de plus en plus visible chez Leiris. Alors peut-être seulement se profile dans l’écriture le désoubli de soi.
Lo scienziato e l’artista
Authors: Arrigo Nino 
Published: January 2019

Il saggio che proponiamo prende avvio da alcune esperienze autobiografiche, contenute nel romanzo americano postmoderno. Quella di Holden Caulfield e quella di Henry Chinasky, alter ego di Charles Bukowski in Panino al prosciutto. Entrambi i romanzi sembrano quasi una forma larvata di autobiografia, dove i protagonisti dipingono una sorta di ‘ritratto dell’artista da giovane’. Tanto Holden, quanto Henry, sembrano, infatti, rappresentare la metafora o, meglio, l’archetipo dell’artista.
Alla maniera di Jakov ed Holden, anche sulla scomparsa dello scienziato catanese Ettore Majorana, sembrerebbe allungarsi l’ombra di Ulisse e dell’Ebreo Errante Assuero. In essa i confini tra il reale e l’immaginario, rimarrebbero evanescenti, indeterminati come l’esistenza delle particelle quantistiche. Il mistero della scomparsa andrebbe pertanto ricercato nella realtà paradossale del mito e degli archetipi, piuttosto che in quella lineare e razionale della storia. A sintetizzare la figura dell’artista e quella dello scienziato è - in una straordinaria autobiografia - Edgar Morin.
L’ethos del mutuo trascinamento
Authors: Mesirca Margherita 
Published: January 2019

Cet article n'est pas disponible au téléchargement en raison du refus de publication de l'auteur en open access
Il est toutefois disponible à la commande au format papier dans la version complète de la revue sur le site des Presses universitaires de Louvain
Raconter la science
Authors: Barbalato Beatrice 
Published: January 2019

Les articles de cette septième livraison de Mnemosyne, o la costruzione del senso, traitent des auto/biographies d’hommes de sciences, de leurs eurêka, de leur ethos.
Les essais s’inscrivent dans quatre grandes lignes directrices : I) la conception de la science et l’expérience directe ; II) l’eurêka ! III) le cinéma et l’image de l’homme de science ; IV) l’interrelation entre humanités et sciences naturelles et mathématiques.
Depuis l’antiquité, une certaine image de l’homme de science prédomine. Intelligence, curiosité, intuition et discipline extrême, tête dans les nuages, sont les caractères paradigmatiques d’Archimède, l’ancêtre des scientifiques. Des autobiographies de scientifiques permettent de comprendre quelle vision ils développent de leur propre vie, souvent soumise à un engagement extreme.
“Introduzione” au numéro 9 de Mnemosyne
Authors: Barbalato Beatrice 
Published: January 2019

Comment les idées surgissent-elles ? Comment reconnaître leur originalité ? Quelles sont les circonstances dans lesquelles s’inscrit ce déclic ? Avec quelle rapidité ou quelle lenteur ? Dans quelles circonstances heureuses ou malheureuses ? L’expression « saisir une idée » souligne bien à quel point une idée peut être conçue comme arrivée par hasard, éphémère et miraculeuse.
Pour les sciences mathématiques et naturelles, comme pour l’art en toutes ses expressions, l’acte créatif est raconté selon des conceptions différentes. Kronos, kairos, ou plus rarement aiôn, do-minent dans une vision ou dans l’autre.
On constate que bien des témoignages insistent sur la chance, le fortuit, sur le privilège excep-tionnel d’avoir été touché par la fortuna.
Françoise Sagan
Authors: Giardino Alessandro 
Published: January 2019

Parallèlement à la rédaction de ses deux premiers romans Bonjour Tristesse et Un certain sourire, Françoise Sagan écrit des carnets de voyage à la demande de l'éditeur en chef de la revue Elle. Sagan prend alors la route de l’Italie et visite Naples, Capri et Venise. Tout au long de ce parcours littéraire, elle revient sur un mythe créateur remontant à ses lectures de jeunesse, et en particulier aux Illuminations d’Arthur Rimbaud. En retraçant des dynamiques mélancoliques derrière l'insouciance saganesque, nous démontrons dans cet article que l’auteure s’écarte des programmes féministes de son époque, aussi bien que de l’opinion de ceux qui l’ont dépeinte comme une jeune fille superficielle et désabusée. Enfin, une lecture interprétative des trois carnets des voyages servira à établir un parallèle entre les textes de fiction de Sagan et sa psycho-biographie, démontrant aussi la persistance du texte-source de Rimbaud dans l’évolution de son imaginaire.
Diagnostic biomarkers of muscle injury and exertional rhabdomyolysis
Authors: Lippi Giuseppe , Schena Federico , Ceriotti Ferruccio 
Published: January 2019

AbstractEarly recognition of muscle injury, up to development of exertional rhabdomyolysis (ER), is essential for many clinical and practical reasons, such as planning the suitable period of recovery and deciding an appropriate time for return to exercise. Albeit magnetic resonance imaging (MRI) remains the reference technique for assessing muscle injuries, and ultrasonography (US) may be a complementary approach for easy, inexpensive and fast screening, the potential drawbacks of both techniques may be overcome by some laboratory tests, which may help guiding both diagnostic reasoning and clinical decision making. Current evidence attest that creatine kinase remains the most validated test across the clinical spectrum of muscles injuries, as its measurement may be helpful for screening subjects with suggestive signs and symptoms, its concentration substantially reflects the amount of injured muscle and its kinetics appears suitable, combined with clinics and results of imaging testing, for making decisions on return to exercise. Relatively low cost and widespread availability are additional advantages of this test. In athletes with ER, myoglobin assessment may provide adjunctive useful information, due to high predictive value for development of acute kidney injury. Regarding other historical biomarkers, namely aldolase and lactate dehydrogenase, the kinetics, correlation with injury severity, laboratory standardization and availability make their measurement unsuitable and redundant. Some innovative biomarkers have also been tested in recent years, including fatty acid-binding proteins and carbonic anhydrase III, myosin light chain 3 and muscle micro RNAs. However, their clinical effectiveness, standardization, availability in clinical laboratories and costs are still regarded as major drawbacks.
Research on correlation of compositions with oestrogenic activity of Cistanche based on LC/Q-TOF-MS/MS technology
Authors: Li Wen-Lan , Ding Jing-Xin , Bai Jing , Hu Yang , Song Hui , Sun Xiang-Ming , Ji Yu-Bin 
Published: January 2019

AbstractLC technology is a recognized method used worldwide to evaluate the quality of traditional Chinese medicines (TCM). The quality of TCM has a direct impact on its efficacy. Therefore, in order to thoroughly reveal how TCM exerts its efficacy, first of all, it is necessary to understand the material basis for its efficacy, and then to control the quality of active compounds. The application of the spectrum-effect relationship method is crucial for determining the pharmacological material basis. The goal of this paper was to investigate the underlying correlations between the chemical profiles and oestrogenic activity of Cistanche, to reveal the active compounds. The chemical profiles of Cistanche were recorded using HPLC/Q-TOF-MS/MS, and oestrogenic activity was determined by the Uterus growth test and the MTT assay. Then combining the results of bivariate analysis, principal component analysis and gray correlation analysis method, fifteen active compounds were identified. They are 8-epiloganic acid, salidroside, syringalide A 3’-α-l-rhamnopyranoside, cistanoside A, echinacoside, cistanoside F, cistanoside B, cistanoside C, osmanthuside B, acteoside, isoacteoside, tubuloside B, 2’-acetylacteoside, and two unknown compounds. This study lays a foundation for in vivo studies of Cistanche and for the development of its clinical application.
Effect of l-carnitine on aspartame-induced oxidative stress, histopathological changes, and genotoxicity in liver of male rats
Authors: Hamza Reham Z. , Al-Eisa Rasha A. , Mehana Amir E. , El-Shenawy Nahla S. 
Published: January 2019

Abstract

Background
Aspartame (ASP) is used for treatment of obesity and diabetes mellitus. This study was designed to illustrate the biochemical responses and histopathological alterations besides the genotoxicity of ASP alone or with l-carnitine (LC) in the liver of rats.

Methods
Animals were separated into six groups: control, lower dose of ASP (ASP-LD; 75 mg/kg), higher dose of ASP (ASP-HD; 150 mg/kg), l-carnitine (LC; 10 mg/kg), ASP-LD plus LC, and ASP-HD plus LC. Treatment was carried out orally for 30 consecutive days.

Results
ASP raised the activity of some enzymes of liver markers and disturbed the lipid profile levels. The hepatic reduced glutathione (GSH) levels, the marker enzymes of antioxidant activities, were obviously diminished, and, possibly, the lipid peroxidation, C-reactive protein, and interleukins levels were increased. ASP significantly increased the DNA deterioration in comparison with the control in a dose-dependent manner. LC prevented ASP-induced liver damage as demonstrated by the enhancement of all the above parameters. Results of histopathological and electron microscopic examination proved the biochemical feedback and the improved LC effect on liver toxicity.

Conclusions
The co-treatment of LC showed different improvement mechanisms against ASP-induced liver impairment. So, the intake of ASP should be regulated and taken with LC when it is consumed in different foods or drinks to decrease its oxidative stress, histopathology, and genotoxicity of liver.