bluuebunny/crossref_metadata_2025_split huggingface dataset:
A 1-year per-patient cost of therapy administration analysis of mosunetuzumab and tisagenlecleucel in relapsed or refractory follicular lymphoma patients receiving two or more lines of systemic therapy
Authors: Bellone Marco , Sabinot Alice , D’Arpino Alessandro , Omodeo Salè Emanuela , Ghislieri Daniela , Pradelli Lorenzo 
Published: December 2024

Objective: A per-patient cost of therapy administration model was developed to estimate the cost of mosunetuzumab vs. tisagenlecleucel in patients with relapsing or refractory follicular lymphoma (R/R FL) receiving two or more lines of systemic therapy (3L+) from both the Italian hospital and societal perspectives.
Methods: A per-patient total cost of therapy administration model was developed to compare the resource consumption of two treatments – mosunetuzumab and tisagenlecleucel. The model considered direct costs such as healthcare labor costs for drug preparation and administration, non-drug consumable costs, and drug purchase. Indirect costs such as patient and caregiver’s loss of productivity, transportation, and relocation were also considered. The unit costs and resource use data were retrieved from literature and standard Italian tariffs. To appraise the impact of patients’ residency on access-to-care and out-of-pocket expenses, three scenario analyses were conducted.
Results: Over 1 year, mosunetuzumab costs approximately one-fourth of tisagenlecleucel per patient. The base-case scenario showed a hospital cost reduction of €158,870 per patient with mosunetuzumab, increasing to €161,974 when including societal costs. Scenario analyses for the societal perspective estimated cost differences of −€161,170, −€166,507, and −€166,811 for scenarios A, B, and C, respectively. Sensitivity analysis indicated that tisagenlecleucel’s price had the greatest impact on cost differences, followed by mosunetuzumab’s price.
Conclusions: This analysis identifies mosunetuzumab as an accessible therapeutic option for 3L+ R/R FL patients in Italy. Future research should collect real-time data and evaluate long-term outcomes.
PIK3CA Mutations and Co-Mutations in Operated Non-Small Cell Lung Carcinoma
Authors: Cokpinar Salih , Erdogdu Ibrahim Halil , Orenay-Boyacioglu Seda , Boyacioglu Olcay , Kahraman-Cetin Nesibe , Meteoglu Ibrahim 
Published: December 2024

Background: Understanding PIK3CA mutations and co-mutations in non-small cell lung carcinoma (NSCLC) is critical to developing personalized treatment strategies. Therefore, this study aims to investigate PIK3CA mutations and the accompanying somatic variations in NSCLC. Methods: This retrospective study included 98 patients over 18 years of age who were diagnosed with NSCLC, operated on, and referred to the Molecular Pathology Laboratory between January 2019 and June 2024 for next-generation sequencing panel tests and ALK-ROS1 FISH analysis. Results: All patients were found to carry PIK3CA mutations. Among the 98 NSCLC patients analyzed, 16 (16.33%) were female and 82 (83.67%) were male. The average age of the patients was 64.53 ± 9.63 years, with an age range of 38–84 years, and the majority were 50 years or older. Of the cases, 51 presented the adenocarcinoma subtype, while the remaining 47 showed the squamous cell carcinoma subtype. A smoking history was present in 77 (78.57%) patients, while 21 (21.43%) had no smoking history. The most frequently detected pathogenic or likely pathogenic PIK3CA variations were c.1633G>A p.E545K (32.65%), c.1624G>A p.E542K (11.22%), c.3140A>G p.H1047R (11.22%), c.3140A>T p.H1047L (5.10%), c.1357G>C p.E453Q (4.08%), and c.3143A>G p.H1048R (2.04%). The top 10 mutations that most commonly accompanied PIK3CA variations were KRAS, NF1, TP53, EGFR, PTEN, BRAF, KIT, CDKN2A, SMARCA4, and ATM mutations, respectively. Conclusions: PIK3CA variations, along with other gene variations, may influence cancer progression and thus may play a crucial role in the determination of targeted treatment strategies.
HUBUNGAN MOTIVASI KESEMBUHAN DENGAN PROSES PENYEMBUHAN LUKA PADA PASIEN DM DI PUSKESMAS GODONG I KABUPATEN GROBOGAN
Authors: Purhadi Purhadi , Fitriana Nur Zuli 
Published: December 2024

LatarBelakang : Bentuk dukungan dan motivasi keluarga dalam proses penyembuhan bagi pasien terbuki dengan pasien yang mengalami sakit diabetes militus melakukan pongobatan rutin ke rumah sakit. Bentuk dukungan lainnya yaitu banyak anggota keluarga membantu pasien atau anggota keluarga yang mengalami sakit diabetes millitus untuk melakukan mobilisasi agar melancarkan proses penyembuhan.. motivasi pasien untuk sembuh juga memberikan kostribusi terhadap kesembuhan penyakitnya dalam menjalani pengobatan agar meringankan gejala, menghambat perelebaran luka. Memperkecil kemungkinan cacat dan memperoleh kualitas yang lebih baikTujuan :Tujuan dari penelitian ini adalah untuk Mengetahui Hubungan Motivasi Kesembuhan Dengan Proses Penyembuhan Luka Pada Pasien Penderita Diabetes Mellitus di Wilayah Kerja Puskesmas Godong I Kabupaten Grobogan .Metode :Jenis penelitian ini adalah Analitik korelasi yakni melakukan analisis dinamika kolerasi antara fenomena, baik antara faktor resiko dengan faktor efek. Pendekatan yang dilakukan dengan Cross Sectional yaitu penelitian untuk mempelajari dinamika kolerasi antara faktor-faktor resiko dengan efek, dengan cara pendekatan, observasi atau pengumpulan data secara bersama-samaHasil : berdasarkan uji Chi Square dapat digunakan dengan nilai p (0,000) < ? (0,05), maka Ha diterima H0 ditolak. Dapat disimpulkan bahwa Terdapat Hubungan Motivasi Kesembuhan Dengan Proses Penyembuhan Luka Pada Pasien Penderita Diabetes Mellitus di Wilayah Kerja Puskesmas Godong I Kabupaten Grobogan.
EFEK ACTIVE CYCLE OF BREATHING TECHNIQUE TERHADAP SESAK NAFAS PADA PENDERITA TUBERKULOSIS DI WILAYAH KERJA PUSKESMAS PURWODADI 1
Authors: Agustiana Mika , Widayati Christina Nur , Fatchulloah Fatchulloah , Nisa Ariefatun 
Published: December 2024

Latar belakang: Tuberkulosis suatu keadaan disebabkan oleh bakteri mycobacterium tuberculosis. Salah satu gejala yang muncul pada tuberkulosis yaitu sesak nafas pada penyakit tuberkulosis yang infiltrasinya sudah setengah bagian paru-paru. Rendahnya keberhasilan dalam mengatasi sesak nafas pada penderita tuberkulosis sehingga dilakukan pemberian yaitu teknik active cycle of breathing technique. Tujuan dari penelitian ini yaitu untuk mengetahui efektivitas active cycle of breathing technique terhadap sesak nafas pada penderita tuberkulosis di wilayah kerja Puskesmas Purwodadi 1.Metode: Pada penelitian ini menggunakan jenis penelitian kuantitatif dengan menggunakan metode penelitian quasy eksperimen dengan desain penelitian pretest-postest control group design. teknik yang digunakan penelitian ini simple random sampling dengan total 28 responden di wilayah kerja Puskesmas Purwodadi 1.Hasil: Hasil uji wilcoxon kelompok intervensi diperoleh p value = 0,000 < ? (0,05) dan pada kelompok kontrol diperoleh p value = 0,157 > ? (0,05) tidak terdapat perubahan yang signifikan.Kesimpulan: Ada perbedaan active cycle of breathing technique dan inhalasi sederhana dengan daun mint terhadap sessak nafas pada penderita tuberkulosis wilayah kerja Puskesmas Purwodadi 1
Theoretical study on structural stability and miscibility of ScAlN alloys: effect of lattice constraint
Authors: Miyamoto Takuto , Akiyama Toru , Kawamura Takahiro 
Published: December 2024

Abstract
The structural stability and miscibility of ScAlN are theoretically investigated on the basis of density functional calculations. The calculations demonstrate that the relative stability between wurtzite and rocksalt structures depends on Sc composition. The lattice constraint of AlN and GaN substrates enhances the stability of the wurtzite structure as well as the miscibility of ScAlN alloys. Furthermore, the calculated energy barrier for polarization switching is also influenced by the lattice constraint. The results give insights into understanding the effect of substrate on structural stability and miscibility of ScAlN alloys.
PENGARUH PERBEDAAN FAKTOR-FAKTOR INDIVIDUAL TERHADAP PERILAKU ETIS MAHASISWA AKUNTANSI
Authors: Lesmanawati Dewi 
Published: December 2024

Tujuan penelitian ini adalah untuk mengidentifikasi perbedaan perilaku etis antara mahasiswa akuntansi dengan locus of control internal dan external, antara mahasiswa akuntansi dan mahasiswa hukum, dan antara mahasiswa akuntansi dalam kategori benevolents dan entitleds. Penelitian ini dilakukan melalui metode survei, dengan kuesioner diberikan kepada responden untuk mendapatkan data. Riset ini dilakukan pada 198 mahasiswa S1 akuntansi dan hukum Universitas Lambung Mangkurat. Penulis menggunakan tes sampel t independen untuk menguji hipotesis penelitian ini. Mereka menguji perbedaan mean antara dua kelompok sampel independen. Untuk menguji hipotesis penulis, program statistik SPSS versi 25 digunakan. Hasilnya menunjukkan bahwa perilaku etis siswa akuntansi dengan locus of control internal dan eksternal berbeda. Terdapat perbedaan besar dalam perilaku etis mahasiswa akuntansi dan hukum, serta perbedaan besar dalam perilaku etis mahasiswa yang termasuk dalam kategori benevolents dan entitileds.
Kata kunci: locus of control, disiplin ilmu, equity sensitivity, perilaku etis
PEMBERIAN PUPUK ORGANIK BIO-SLURRY CAIR DAN MACAM MULSA ORGANIK PADA BUDIDAYA TERONG (Solanum melongena L.) VARIETAS JENO FI
Authors: Hadi Pramono hadi , Al Rizal Miftah Firdaus , Rahayu Tri 
Published: December 2024

ABSTRACT
This study aims to determine the effect of application of liquid bio-slurry organic fertilizer and kinds of organic mulch on the cultivation of eggplant (Solanum melongena L.) Jeno F1 varieties.. This research was conducted from November to February 2020 in Kuncen Waru Village, Baki District, Sukoharjo Regency. This study used an environmental design with a basic pattern Randomized Complete Block Design (RCBD) consisting of 2 treatment factors with 9 treatment combinations and repeated 3 times. The first treatment factor, giving mulch (M) consisting of 3 levels M1 = straw mulch M2 = reed mulch and M3 = bamboo leaf mulch, the second treatment factor, giving concentration of bio-slurry liquid (S) consisting of 3 levels S1 = 5 ml bio-slurry/ liter water, S2 = 10 m bio-slurry / liter water and S3 = 15 ml bio-slurry / liter water. The results of this study indicate that the treatment of organic mulch has a very significant effect on the weight of fruit per plant, the number of fruits per plant and the fresh weight per plant, and also has a significant effect on the dry weight per plant. Liquid bio-slurry fertilizer has a very significant effect on fruit weight per plant, number of fruits per plant and fresh weight per plant, and also has a significant effect on dry weight per plant. The best combination is M1S3 straw organic mulch treatment and
bio-slurry 15 ml / liter of water. This gives the highest yield in the parameters of plant height 59.89 cm, fruit weight per plant 146.54 g, number of fruits per plant 6.56, fruit diameter 5.06 cm, fresh biomass weight per plant 62.20 g, and weight dry biomass per plant 39.06 g.
Keywords: types of organic mulch, bio-slurry liquid, eggplant
Potensial Produk Unggulan Bunga Kol Untuk Dikembangkan Di Kecamatan Selo Kabupaten Boyolali
Authors: Widyastuti Yuan , Ilham Pamungkas Pasindra , Suci Lestariana Dwi 
Published: December 2024

Bunga kol (Brassica oleracea var. botrytis L.) menjadi salah satu komoditas hortikultura yang dikembangkan di wilayah Kecamatan Selo. Tingginya kandungan gizi, banyaknya manfaat bagi kesehatan, tingginya permintaan pasar serta jangka waktu panen yang cukup singkat menjadikan komoditas ini dilirik oleh petani di daerah tersebut. Potensi komoditas bunga kol sebagai acuan pengembangan untuk dibudiayakan petani sangat penting untuk diketahui. Penelitian ini juga diharapkan sebagai acuan pengembangan komoditas yang dibudiayakan petani di Kecamatan Selo. Metode yang digunakan pada penelitian ini yaitu observasi langsung pada proses tataniaga bunga kol di Pasar Sayur Cepogo dan metode wawancara secara langsung dengan reponden. Bunga kol merupakan tanaman sayuran yang cocok dikembangkan di daerah sub topis dengan ketinggian 1.000-2000mdpl. Berdasarkan hasil wawancara dengann resonden, permasalahan yang dihadapi yaitu adanya penyakit akar gada yang menyerang tanaman bunga kol. Hal ini dapat menyebabkan pernurunan produktifitas. Namun penyakit akar gada tersebut dapat dikendalikan dengan trichoderma. Terlepas dari permasalahan tersebut, permintaan kebutuhan produk bunga kol di pasar yang semakin hari semakin meningkat membuat produksi bunga kol di Indonesia juga meningkat. Produsen bunga kol tertinggi di Kabupaten Boyolali yaitu Kecamatan Selo sebanyak 20.577,2 Ton, selanjutnya Kecamatan Mojosongo sebanyak 24,5 Ton, dan terakhir Kecamatan Teras sebanyak 6,7 Ton. Seningga dari data tersebut potensi budidaya bunga kol di Kecamatan Selo Kabupaten Boyolali sangat besar.
PENGEMBANGAN BUKU SAKU BERBASIS MIND MAPPING PADA MATERI MENULIS TEKS BIOGRAFI DI SMK
Authors: Telaumbanua Murniati , Harefa Trisman 
Published: December 2024

Permasalahan yang ada di SMK Negeri 1 Sogaeadu yaitu kurangnya variasi bahan ajar dan hanya berpusat pada buku paket sehingga siswa tidak mampu belajar secara mandiri. Jenis penelitian ini merupakan penelitian pengembangan menggunakan model 4D. Peneltian ini dilakukan di SMK Negeri 1 Sogaeadu.menggunakan instrumen lembar observasi, lembar wawancara dan angket. Hasil penelitian ini berupa buku saku dengan materi biografi. Hasil penilaian oleh ahli materi mencapai persentasi 95,9%, ahli bahasa mencapai rata-rata 92,8%, ahli desain 82,5%. Hasil penilaian dari angket respon peserta didik pada uji perorangan mencapai rata-rata 91,6% dengan jumlah 3 orang, uji kelompok kecil mencapai 94,4% dengan jumlah 6 orang, dan uji lapangan 94,1% dengan jumlah 21 orang, hasil penilaian dari angket peserta didik mendapat kriteria sangat baik. Setelah itu dilanjutkan dengan penilaian keefektivitas siswa dengan uji perorangan rata-rata 93.3%, uji kelompok kecil rata-rata 90%, uji lapangan 93,3%. Hasil dari penilaian efektivitas mencapai kriteria sangat efektif. Berdasarkan hasil penelitian disimpulkan bahwa buku saku layak, dan praktis digunakan. Diharapkan buku saku ini dapat digunakan oleh guru bahasa Indonesia untuk dijadikan bahan ajar dan untuk meningkatkan kualitas pembelajaran dan menjadikan hasil penelitian ini menjadi referensi bagi peneliti lain.
PENINGKATAN KEMAMPUAN MENGANALISIS MAKNA DAN KEBAHASAAN TEKS BIOGRAFI MENGGUNAKAN MODEL INKUIRI DI SMK
Authors: Gulo Seniadi , Zega Imansudi 
Published: December 2024

Biografi adalah riwayat hidup seseorang yang ditulis oleh orang lain. Dalam biografi disajikan sejarah hidup, pengalaman-pengalaman, sampai kisah sukses orang yang sedang diulas. Tujuan penelitian ini untuk meningkatkan kemampuan siswa menganalisis makna dan kebahasaan teks biografi dengan menggunakan model pembelajaran inkuiri. Penelitian tindakan kelas ini dilaksanakan dua siklus menggunakan prosedur pelaksanaan, perencanaan, tindakan observasi, refleksi. Subjek penelitian siswa kelas X-TKJ yang berjumlah 18 orang siswa, laki-laki 8 orang dan perempuan 10 orang. Hasil penelitian ini menunjukkan bahwa nilai terendah 42,4, nilai tertinggi 87,5 dengan persentase ketuntasan klasikal 22,1%. Siklus II nilai terendah 70, nilai tertinggi 92,5 dengan persentase ketuntasan klasikal 94,5% telah mencapai target ketuntasan klasikal yang telah ditentukan 80%. Hasil observasi peneliti siklus I pertemuan pertama 50% dan yang tidak terlaksana 50%, pertemuan kedua 56,25%. Hasil observasi peneliti siklus II pertemuan pertama 81,25%, pertemuan kedua 93,75%. Hasil lembar observasi siswa siklus I pertemuan pertama 66,3%, pertemuan kedua 69,0%. Siklus II pertemuan pertama 85,7%, pertemuan kedua 92,0%. Disimpulkan bahwa penerapan model pembelajaran Inkuiri dapat meningkatkan kemampuan menganalisis teks biografi di kelas X-TKJ. Saran bagi guru di SMK hasil penelitian ini sebagai pedoman dalam keterampilan membaca, bagi siswa dapat meningkatkan minat membaca, bagi UNIAS sebagai referensi di masa yang akan mendatang.
Penerapan Metode Total Productive Maintenance Dengan Overall Equipment Effectiveness (OEE) Pada Mesin Grinding di PT. VPRK
Authors: Putra Abrardy Firlana , Kusnadi Kusnadi 
Published: December 2024

This research focuses on analyzing the implementation “of Total Productive Maintenance (TPM)” at PT. VPRK “by” utilizing “Overall Equipment Effectiveness (OEE) as an indicator” to assess “the” performance of grinding machines at PT. VPRK. The aim of the research is to evaluate the effectiveness and efficiency of the machine by identifying inhibiting factors that influence the performance of the grinding machine. The TPM method is applied to increase availability, quality and overall machine performance. OEE is used as a critical measuring tool to assess productivity and operational efficiency. The research results show that the OEE value of grinding machines in the January 2023 period is 79.78%. This value is not in accordance with the world-class OEE value standard, which is 85%. The biggest factor that influences the low OEE value is because the machine downtime is quite high, which affects the machine availability value so the machine availability value is 81.16%.
Keywords: Maintenance, Overall Equipment Effectiveness, Total Productive Maintenance
Loss-of-function mutations of microRNA-142-3p promote ASH1L expression to induce immune evasion and hepatocellular carcinoma progression
Authors: Yu Xing-Hui , Xie Yan , Yu Jian , Zhang Kun-Ning , Guo Zhou-Bo , Wang Di , Li Zhao-Xian , Zhang Wei-Qi , Tan Yu-Ying , Zhang Li , Jiang Wen-Tao 
Published: December 2024

BACKGROUND
Hepatocellular carcinoma (HCC) has been a pervasive malignancy throughout the world with elevated mortality. Efficient therapeutic targets are beneficial to treat and predict the disease. Currently, the exact molecular mechanisms leading to the progression of HCC are still unclear. Research has shown that the microRNA-142-3p level decreases in HCC, whereas bioinformatics analysis of the cancer genome atlas database shows the ASH1L expression increased among liver tumor tissues. In this paper, we will explore the effects and mechanisms of microRNA-142-3p and ASH1L affect the prognosis of HCC patients and HCC cell bioactivity, and the association between them.
AIM
To investigate the effects and mechanisms of microRNA-142-3p and ASH1L on the HCC cell bioactivity and prognosis of HCC patients.
METHODS
In this study, we grouped HCC patients according to their immunohistochemistry results of ASH1L with pathological tissues, and retrospectively analyzed the prognosis of HCC patients. Furthermore, explored the roles and mechanisms of microRNA-142-3p and ASH1L by cellular and animal experiments, which involved the following experimental methods: Immunohistochemical staining, western blot, quantitative real-time-polymerase chain reaction, flow cytometric analysis, tumor xenografts in nude mice, etc . The statistical methods involved in this study contained t -test, one-way analysis of variance, the χ 2 test, the Kaplan-Meier approach and the log-rank test.
RESULTS
In this study, we found that HCC patients with high expression of ASH1L possess a more recurrence rate as well as a decreased overall survival rate. ASH1L promotes the tumorigenicity of HCC and microRNA-142-3p exhibits reduced expression in HCC tissues and interacts with ASH1L through targeting the ASH1L 3′untranslated region. Furthermore, microRNA-142-3p promotes apoptosis and inhibits proliferation, invasion, and migration of HCC cell lines in vitro via ASH1L . For the exploration mechanism, we found ASH1L may promote an immunosuppressive microenvironment in HCC and ASH1L affects the expression of the cell junction protein zonula occludens-1, which is potentially relevant to the immune system.
CONCLUSION
Loss function of microRNA-142-3p induces cancer progression and immune evasion through upregulation of ASH1L in HCC. Both microRNA-142-3p and ASH1L can feature as new biomarker for HCC in the future.
In House Training (IHT): Upaya Meningkatkan Kompetensi Guru dalam Memanfaatkan Media Digital Canva
Authors: Caswita Caswita 
Published: December 2024

This research aims to improve teacher competency in learning through In House Training (IHT) in the use of Canva media. This research method uses a pre-experimental design type of one-group pre-test post-test design. The research was conducted at Syekh Tubagus Abdullah Elementary School, Purbaratu District, Tasikmalaya City. The research was conducted at the beginning of the even semester 2021/2022, in January-June 2022. The population in this research was all teachers at Syekh Tubagus Abdullah Elementary School, Purbaratu District, totaling 10 people. The results of the research show that based on the data obtained, in phase I as many as 9 teachers at Syekh Tubagus Abdullah Elementary School were able to master the material for making Canva learning videos well. Only one teacher scored below average. Based on the results of phase 1, it is necessary to carry out phase II IHT activities again. Meanwhile, in phase II, the results of the implementation of In House Training were based on instruments that had been filled in by 10 respondents or participants (Teachers) and had achieved an average score of 100, this means that most of the indicators based on previous provisions could be achieved very well. Based on existing data, the conclusion is that IHT activities have succeeded in increasing teacher competence in utilizing animated videos in learning activities.
CRIRES+ and ESPRESSO Reveal an Atmosphere Enriched in Volatiles Relative to Refractories on the Ultrahot Jupiter WASP-121b
Authors: Pelletier Stefan , Benneke Björn , Chachan Yayaati , Bazinet Luc , Allart Romain , Hoeijmakers H. Jens , Lavail Alexis , Prinoth Bibiana , Coulombe Louis-Philippe , Lothringer Joshua D. , Parmentier Vivien , Smith Peter , Borsato Nicholas , Thorsbro Brian 
Published: December 2024

Abstract
One of the outstanding goals of the planetary science community is to measure the present-day atmospheric composition of planets and link this back to formation. As giant planets are formed by accreting gas, ices, and rocks, constraining the relative amounts of these components is critical to understand their formation and evolution. For most known planets, including the solar system giants, this is difficult as they reside in a temperature regime where only volatile elements (e.g., C, O) can be measured, while refractories (e.g., Fe, Ni) are condensed to deep layers of the atmosphere where they cannot be remotely probed. With temperatures allowing for even rock-forming elements to be in the gas phase, ultrahot Jupiter atmospheres provide a unique opportunity to simultaneously probe the volatile and refractory content of giant planets. Here, we directly measure and obtain bounded constraints on the abundances of volatile C and O as well as refractory Fe and Ni on the ultrahot giant exoplanet WASP-121b. We find that ice-forming elements are comparatively enriched relative to rock-forming elements, potentially indicating that WASP-121b formed in a volatile-rich environment much farther away from the star than where it is currently located. The simultaneous constraint of ice and rock elements in the atmosphere of WASP-121b provides insights into the composition of giant planets otherwise unattainable from solar system observations.