bluuebunny/crossref_metadata_2025_split huggingface dataset:
Xerostomia in patients on chronic hemodialysis: An update
Authors: Bossola Maurizio 
Published: May 2019

AbstractXerostomia, or dryness of oral cavity, is relatively common in patients on chronic hemodialysis and significantly impairs their quality of life. Xerostomia is often the consequence of reduced salivary flow resulting from atrophy and fibrosis of the salivary glands, an event that is of uncertain origin. Many medications commonly used in dialysis patients may also cause or exacerbate xerostomia. Its consequences may be serious and disturbing and include difficulties in chewing, swallowing, tasting, and speaking; increased risk of oral disease, including lesions of the mucosa, gingiva and tongue; bacterial and fungal infections, such as candidiasis, dental caries, and periodontal disease; interdialytic weight gain resulting from increased fluid intake; and a reduction in the quality of life. Therapeutically, stimulation of the salivary glands to increase the production of saliva mechanically by chewing‐gum, mouthwash, acupressure, or transcutaneous electrical stimulation has had modest success. However, the long‐term effectiveness of such treatments still needs to be investigated and defined. Xerostomia remains a frustrating and disturbing symptom for patients on hemodialysis. Further efforts should be made to find the causes and the mechanisms of the reduced salivary flow observed in patients on chronic hemodialysis.
Generation of cattle knockout for galactose‐α1,3‐galactose and N‐glycolylneuraminic acid antigens
Authors: Perota Andrea , Lagutina Irina , Duchi Roberto , Zanfrini Elisa , Lazzari Giovanna , Judor Jean Paul , Conchon Sophie , Bach Jean Marie , Bottio Tomaso , Gerosa Gino , Costa Cristina , Galiñanes Manuel , Roussel Jean Christian , Padler‐Karavani Vered , Cozzi Emanuele , Soulillou Jean Paul , Galli Cesare 
Published: May 2019

AbstractTwo well‐characterized carbohydrate epitopes are absent in humans but present in other mammals. These are galactose‐α1,3‐galactose (αGal) and N‐glycolylneuraminic acid (Neu5Gc) which are introduced by the activities of two enzymes including α(1,3) galactosyltransferase (encoded by the GGTA1 gene) and CMP‐Neu5Gc hydroxylase (encoded by the CMAH gene) that are inactive in humans but present in cattle. Hence, bovine‐derived products are antigenic in humans who receive bioprosthetic heart valves (BHVs) or those that suffer from red meat syndrome. Using programmable nucleases, we disrupted (knockout, KO) GGTA1 and CMAH genes encoding for the enzymes that catalyse the synthesis of αGal and Neu5Gc, respectively, in both male and female bovine fibroblasts. The KO in clonally selected fibroblasts was detected by polymerase chain reaction (PCR) and confirmed by Sanger sequencing. Selected fibroblasts colonies were used for somatic cell nuclear transfer (SCNT) to produce cloned embryos that were implanted in surrogate recipient heifers. Fifty‐three embryos were implanted in 33 recipients heifers; 3 pregnancies were carried to term and delivered 3 live calves. Primary cell cultures were established from the 3 calves and following molecular analyses confirmed the genetic deletions. FACS analysis showed the double‐KO phenotype for both antigens confirming the mutated genotypes. Availability of such cattle double‐KO model lacking both αGal and Neu5Gc offers a unique opportunity to study the functionality of BHV manufactured with tissues of potentially lower immunogenicity, as well as a possible new clinical approaches to help patients with red meat allergy syndrome due to the presence of these xenoantigens in the diet.
Development of Damage-Tolerant and Fracture-Resistant Materials by Utilizing the Material Inhomogeneity Effect
Authors: Kolednik O. , Kasberger R. , Sistaninia M. , Predan J. , Kegl M. 
Published: May 2019

AbstractThe improvement of fracture strength by insertion of thin, soft interlayers is a strategy observed in biological materials such as deep-see sponges. The basic mechanism is a reduction of the crack driving force due to the spatial variation of yield strength and/or Young's modulus. The application of this “material inhomogeneity effect” is demonstrated in this paper. The effectiveness of various interlayer configurations is investigated by numerical simulations under application of the configurational force concept. Laminated composites, made of high-strength tool steels as matrix materials and low-strength deep-drawing steel as interlayer material, were manufactured by hot press bonding. The number of interlayers and the interlayer thickness were varied. Fracture mechanics experiments show crack arrest in the first interlayer and significant improvements in fracture toughness, even without the occurrence of other toughening mechanisms, such as interface delamination. The application of the material inhomogeneity effect for different types of matrix materials is discussed.
Supercritical Carbon Dioxide Centripetal Compressor—Aerodynamic Design and Analysis of Off Design Conditions
Authors: Du Xuefei , Yu Dengtao , Luo Dan , Huang Diangui 
Published: May 2019

Abstract
Based on the design of the supercritical carbon dioxide (SCO2) centripetal compressor, this paper adopts the orthogonal design test method to optimize the pear-shaped volute, designs the front guide vane with the third-order Bezier curve, and designs the outlet by the equal section method. The numerical simulation calculation and analysis of the design conditions and variable conditions of the SCO2 centripetal compressor are carried out. The results at design conditions show that the isentropic efficiency is 92%, the pressure ratio is 1.21, and the mass flow rate is 195.9 kg/s, which is close to the thermal design and level simulation results; the results of variable conditions show that the efficiency of the SCO2 centripetal compressor-flow and pressure ratio-flow characteristic line is similar to that of multistage axial flow compressor. The supercritical carbon dioxide centripetal compressor designed in this paper meets the design requirements, and its feasibility is proved through numerical simulation.
Clinician-targeted interventions to improve advance care planning in heart failure: a systematic review and meta-analysis
Authors: Schichtel Markus , Wee Bee , Perera Rafael , Onakpoya Igho , Albury Charlotte , Barber Sarah 
Published: May 2019

ObjectiveAdvance care planning (ACP) is widely advocated to contribute to better outcomes for patients suffering from heart failure. But clinicians appear hesitant to engage with ACP. Our aim was to identify interventions with the greatest potential to engage clinicians with ACP in heart failure.MethodsA systematic review and meta-analysis. We searched CINAHL, Cochrane Central Register of Controlled Trials, Database of Systematic Reviews, Embase, ERIC, Ovid MEDLINE, Science Citation Index and PsycINFO for randomised controlled trials (RCTs) from inception to January 2018. Three reviewers independently extracted data, assessed risk of bias (Cochrane risk of bias tool), the quality of evidence (GRADE) and intervention synergy according to Template for Intervention Description and Replication. ORs were calculated for pooled effects.ResultsOf 14 175 articles screened, we assessed the full text of 131 studies. 13 RCTs including 3709 participants met all of the inclusion criteria. The intervention categories of patient-mediated interventions (OR 5.23; 95% CI 2.36 to 11.61), reminder systems (OR 3.65; 95% CI 1.47 to 9.04) and educational meetings (OR 2.35; 95% CI 1.29 to 4.26) demonstrated a favourable effect to engage clinicians with the completion of ACP.ConclusionThe review provides evidence from 13 published RCTs and suggests that interventions that involve patients to change clinical practice, reminder systems and educational meetings have the greatest effect in improving the implementation of ACP in heart failure.
Achieving comparable perfusion results across vendors. The next step in standardizing stroke care: a technical report
Authors: Bathla Girish , Limaye Kaustubh , Policeni Bruno , Klotz Ernst , Juergens Markus , Derdeyn Colin 
Published: May 2019

BackgroundThe role of mechanical thrombectomy in acute ischemic stroke (AIS) has been further expanded by recent trials which relied on the results of CT perfusion (CTP) imaging. However, CTP parameters for ischemia and infarct can vary significantly across different vendors.MethodsWe compared the outcomes of the Siemens CTP software against the clinically validated RAPID software in 45 consecutive patients with suspected AIS. Both perfusion softwares initially processed images using vendor defined parameters for hypoperfusion and non-viable tissue. The software thresholds on the Siemens software were decrementally altered to see if concordant results between softwares could be attained.ResultsAt baseline settings, the mean values for core infarct and hypoperfusion were different (mean of 30/69 mL, respectively, for RAPID and 49/77 mL for Siemens). However, reducing the threshold values for the later software showed a concordance of values at a relative cerebral blood flow <20%, with resulting core infarct and hypoperfusion volumes at 31/69 mL, respectively, for the Siemens software. A Wilcoxon paired test showed no significant difference between the calculated core infarct and hypoperfusion values, both for the entire population as well as for the subgroup of patients with large vessel occlusion.ConclusionEquivalent CTP results between vendor softwares may be attainable by altering the thresholds for hypoperfused and non-viable tissue, despite differences in acquisition techniques, post-processing, and scanners.
Ketogenic diet in combination with voluntary exercise impacts markers of hepatic metabolism and oxidative stress in male and female Wistar rats
Authors: Moore Mary P. , Cunningham Rory P. , Kelty Taylor J. , Boccardi Luigi R. , Nguyen Nhu Y. , Booth Frank W. , Rector R. Scott 
Published: May 2019

Ketogenic diets (KDs) are shown to benefit hepatic metabolism; however, their effect on the liver when combined with exercise is unknown. We investigated the effects of a KD versus a “western” diet (WD) on markers of hepatic lipid metabolism and oxidative stress in exercising rats. Male and female Wistar rats with access to voluntary running wheels were randomized to 3 groups (n = 8–14 per group): standard chow (SC; 17% fat), WD (42% fat), or KD (90.5% fat) for 7 weeks. Body fat percentage (BF%) was increased in WD and KD versus SC, although KD females displayed lower BF% versus WD (p ≤ 0.05). Liver triglycerides were higher in KD and WD versus SC but were attenuated in KD females versus WD (p ≤ 0.05). KD suppressed hepatic markers of de novo lipogenesis (fatty acid synthase, acetyl coenzyme A carboxylase) and increased markers of mitochondrial biogenesis/content (peroxisome proliferator activated receptor-1α, mitochondrial transcription factor A (TFAM), and citrate synthase activity). KD also increased hepatic glutathione peroxidase 1 and lowered oxidized glutathione. Female rats exhibited elevated hepatic markers of mitochondrial biogenesis (TFAM), mitophagy (light chain 3 II/I ratio, autophagy-related protein 12:5), and cellular energy homeostasis (phosphorylated 5′AMP-activated protein kinase/5′AMP-activated protein kinase) versus males. These data highlight that KD and exercise beneficially impacts hepatic metabolism and oxidative stress and merits further investigation. Novelty KD feeding combined with exercise improved hepatic oxidative stress, suppressed markers of de novo lipogenesis, and increased markers of mitochondrial content versus WD feeding. Males and females responded similarly to combined KD feeding and exercise. Female rats exhibited elevated hepatic markers of autophagy/mitophagy and energy homeostasis compared with male rats.
Nicotinic acetylcholine receptor subunit α7-knockout mice exhibit degraded auditory temporal processing
Authors: Felix Richard A. , Chavez Vicente A. , Novicio Dyana M. , Morley Barbara J. , Portfors Christine V. 
Published: May 2019

The CHRNA7 gene that encodes the α7-subunit of the nicotinic acetylcholine receptor (α7-nAChR) has been associated with some autism spectrum disorders and other neurodevelopmental conditions characterized, in part, by auditory and language impairment. These conditions may include auditory processing disorders that represent impaired timing of neural activity, often accompanied by problems understanding speech. Here, we measure timing properties of sound-evoked activity via the auditory brainstem response (ABR) of α7-nAChR knockout mice of both sexes and wild-type colony controls. We find a significant timing delay in evoked ABR signals that represents midbrain activity in knockouts. We also examine spike-timing properties of neurons in the inferior colliculus, a midbrain nucleus that exhibits high levels of α7-nAChR during development. We find delays of evoked responses along with degraded spiking precision in knockout animals. We find similar timing deficits in responses of neurons in the superior paraolivary nucleus and ventral nucleus of the lateral lemniscus, which are brainstem nuclei thought to shape temporal precision in the midbrain. In addition, we find that other measures of temporal acuity including forward masking and gap detection are impaired for knockout animals. We conclude that altered temporal processing at the level of the brainstem in α7-nAChR-deficient mice may contribute to degraded spike timing in the midbrain, which may underlie the observed timing delay in the ABR signals. Our findings are consistent with a role for the α7-nAChR in types of neurodevelopmental and auditory processing disorders and we identify potential neural targets for intervention. NEW & NOTEWORTHY Disrupted signaling via the α7-nicotinic acetylcholine receptor (α7-nAChR) is associated with neurodevelopmental disorders that include impaired auditory processing. The underlying causes of dysfunction are not known but a common feature is abnormal timing of neural activity. We examined temporal processing of α7-nAChR knockout mice and wild-type controls. We found degraded spike timing of neurons in knockout animals, which manifests at the level of the auditory brainstem and midbrain.
Association of Mental Health Conditions With Participation in Cardiac Rehabilitation
Authors: Krishnamurthi Nirupama , Schopfer David W. , Shen Hui , Whooley Mary A. 
Published: May 2019

Background
Mental health conditions are associated with adverse cardiovascular outcomes in patients with ischemic heart disease, and much of this risk can be attributed to poor health behaviors. Although all patients with ischemic heart disease should be referred for cardiac rehabilitation (CR), whether patients with mental health conditions are willing to participate in CR programs is unknown. We sought to compare CR participation rates among patients with ischemic heart disease with versus without comorbid depression and/or posttraumatic stress disorder (PTSD).

Methods and Results

We used national electronic health records to identify all patients hospitalized for acute myocardial infarction or coronary revascularization at Veterans Health Administration hospitals between 2010 and 2014. Multivariable logistic regression models were used to determine whether comorbid depression/PTSD was associated with CR participation during the 12 months after hospital discharge. Of the 86 537 patients hospitalized for ischemic heart disease between 2010 and 2014, 24% experienced PTSD and/or depression. Patients with PTSD and/or depression had higher CR participation rates than those without PTSD or depression (11% versus 8%;
P
<0.001). In comparison to patients without PTSD or depression, the odds of participation was 24% greater in patients with depression alone (odds ratio, 1.24; 95% CI, 1.15–1.34), 38% greater in patients with PTSD alone (odds ratio, 1.38; 95% CI, 1.24–1.54), and 57% greater in patients with both PTSD and depression (odds ratio, 1.57; 95% CI, 1.43–1.74).

Conclusions
Among patients with ischemic heart disease, the presence of comorbid depression and/or PTSD is associated with greater participation in CR, providing an important opportunity to promote healthy lifestyle behaviors and reduce adverse cardiovascular outcomes among these patients.
Relationship among the potato rot nematode, Ditylenchus destructor, densities in soil, root and garlic (Allium sativum) bulbs, and rot damage in stored garlic bulbs
Authors: Cheng Zejun , Toyota Koki , Aoyama Rie 
Published: May 2019

Summary
The potato rot nematode, Ditylenchus destructor, threatens garlic production in Japan. The objectives of this study were to determine the relationships of D. destructor densities in soil, garlic roots and outer skins of garlic bulbs, and damage to bulbs that rot during storage. Ditylenchus destructor densities were evaluated with the real-time PCR method. There was a significant positive correlation between D. destructor densities in soil at planting and those in the outer skin of garlic bulbs at harvest in 2016, but not in 2017. Ditylenchus destructor densities in outer skins at harvest were consistently low when those in roots at harvest were lower than 80 ind. (0.05 g)−1. No damage to garlic bulbs after storage was observed when D. destructor densities in outer skins were lower than 300 ind. (0.05 g)−1. These results indicate that D. destructor densities in roots and outer skins may be a good indicator to estimate nematode damage to garlic bulbs after storage.
Aḥmad b. Ḥanbal’s Legal Opinions on the Fight against Bābak’s Uprising: “I don’t know of anyone who is more harmful to Islam than he, the evil wretch”
Authors: al-Sarhan Saud 
Published: May 2019

Abstract
In this article, Aḥmad b. Ḥanbal’s role in the fight against Bābak’s uprising and his legal opinions on the legitimacy and rules of this fight are presented. Normally reticent in all matters political, Ibn Ḥanbal took an uncharacteristically strong stance against Bābak, claiming he did not know of anything “more harmful to Islam” than Bābak and Khurramism. Focus in the article is on how Ibn Ḥanbal regarded Babāk’s revolt and why he took an active role against it despite what could be called his general attitude of political quietism.
An Idealized Numerical Study of Shear-Relative Low-Level Mean Flow on Tropical Cyclone Intensity and Size
Authors: Chen Buo-Fu , Davis Christopher A. , Kuo Ying-Hwa 
Published: May 2019

Abstract
Given comparable background vertical wind shear (VWS) magnitudes, the initially imposed shear-relative low-level mean flow (LMF) is hypothesized to modify the structure and convective features of a tropical cyclone (TC). This study uses idealized Weather Research and Forecasting Model simulations to examine TC structure and convection affected by various LMFs directed toward eight shear-relative orientations. The simulated TC affected by an initially imposed LMF directed toward downshear left yields an anomalously high intensification rate, while an upshear-right LMF yields a relatively high expansion rate. These two shear-relative LMF orientations affect the asymmetry of both surface fluxes and frictional inflow in the boundary layer and thus modify the TC convection. During the early development stage, the initially imposed downshear-left LMF promotes inner-core convection because of high boundary layer moisture fluxes into the inner core and is thus favorable for TC intensification because of large radial fluxes of azimuthal mean vorticity near the radius of maximum wind in the boundary layer. However, TCs affected by various LMFs may modify the near-TC VWS differently, making the intensity evolution afterward more complicated. The TC with a fast-established eyewall in response to the downshear-left LMF further reduces the near-TC VWS, maintaining a relatively high intensification rate. For the upshear-right LMF that leads to active and sustained rainbands in the downshear quadrants, TC size expansion is promoted by a positive radial flux of eddy vorticity near the radius of 34-kt wind (1 kt ≈ 0.51 m s−1) because the vorticity associated with the rainbands is in phase with the storm-motion-relative inflow.
The clinical utility of structural neuroimaging in first-episode psychosis: A systematic review
Authors: Forbes Malcolm , Stefler Denes , Velakoulis Dennis , Stuckey Stephen , Trudel Jean-Francois , Eyre Harris , Boyd Melinda , Kisely Steve 
Published: May 2019

Background: Australian and US guidelines recommend routine brain imaging, either computed tomography or magnetic resonance imaging, to exclude structural lesions in presentations for first-episode psychosis. The aim of this review was to examine the evidence for the appropriateness and clinical utility of this recommendation by assessing the frequency of abnormal radiological findings in computed tomography and magnetic resonance imaging scans among patients with first-episode psychosis. Methods: PubMed and Embase database were searched from inception to April 2018 using appropriate MeSH or Emtree terms. Studies were included in the review if they reported data on computed tomography or magnetic resonance imaging scan findings of individuals with first-episode psychosis. No restriction on the geographical location of the study or the age of participants was applied. We calculated the percentage of abnormal radiological findings in each study, separately by the two diagnostic methods. Results: There were 16 suitable studies published between 1988 and 2017, reporting data on an overall 2312 patients with first-episode psychosis. Most were observational studies with a retrospective design and the majority examined patients with computed tomography. While structural abnormalities were a relatively common finding, these rarely required clinical intervention (range across studies: 0–60.7%; median: 3.5%) and were very rarely the cause of the psychotic symptoms (range: 0–3.3%; median: 0%). Only 2 of the 16 studies concluded that brain imaging should be routinely ordered in first-episode psychosis. Conclusion: There is insufficient evidence to suggest that brain imaging should be routinely ordered for patients presenting with first-episode psychosis without associated neurological or cognitive impairment. The appropriate screening procedure for structural brain lesions is conventional history-taking, mental status and neurological examination. If intracranial pathology is suspected clinically, a magnetic resonance imaging or computed tomography scan should be performed depending on the clinical signs, the acuity and the suspected pathology. National guidelines should reflect evidence-based data.