bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prioritisation of oncology therapeutic targets using CRISPR-Cas9 screening
Authors: Behan Fiona M , Iorio Francesco , Gonçalves Emanuel , Picco Gabriele , Beaver Charlotte M , Santos Rita , Rao Yanhua , Ansari Rizwan , Harper Sarah , Jackson David Adam , McRae Rebecca , Pooley Rachel , Wilkinson Piers , Dow David , Buser-Doepner Carolyn , Stronach Euan A. , Saez-Rodriguez Julio , Yusa Kosuke , Garnett Mathew J 
Published: December 2018

SummaryFunctional genomics approaches can overcome current limitations that hamper oncology drug development such as lack of robust target identification and clinical efficacy. Here we performed genome-scale CRISPR-Cas9 screens in 204 human cancer cell lines from 12 cancer-types and developed a data-driven framework to prioritise cancer therapeutic candidates. We integrated gene cell fitness effects with genomic biomarkers and target tractability for drug development to systematically prioritise new oncology targets in defined tissues and genotypes. Furthermore, we took one of our most promising dependencies, Werner syndrome RecQ helicase, and verified it as a candidate target for tumours with microsatellite instability. Our analysis provides a comprehensive resource of cancer dependencies, a framework to prioritise oncology targets, and nominates specific new candidates. The principles described in this study can transform the initial stages of the drug development process contributing to a new, diverse and more effective portfolio of oncology targets.
Romantic jealousy is positively associated with fronto-striatal, insula and limbic responses to angry faces
Authors: Zheng Xiaoxiao , Luo Lizhu , Li Jialin , Xu Lei , Zhou Feng , Gao Zhao , Becker Benjamin , Kendrick Keith M. 
Published: December 2018

AbstractRomantic jealousy is a complex social emotion combining the different primary emotions of anger, fear and sadness. Previous evidence has suggested the involvement of fronto-striatal dopaminergic circuitry in clinical pathological jealousy, although little is known about overlaps with the neural representation of primary emotions involved in non-morbid jealousy. In the current study, 85 healthy subjects underwent fMRI during resting state and an emotional face recognition paradigm. A total of 150 faces (happy, angry, fearful, sad, neutral) were presented and subjects were required to identify the expression and rate its intensity. Trait romantic jealousy was assessed using the Multidimensional Jealousy Scale. Behavioral results showed that only intensity ratings of angry faces were positively associated with subjects’ jealousy scores. During processing of angry versus neutral expression faces, subjects with higher jealousy scores exhibited greater activation in the right thalamus, insula, fusiform gyrus and hippocampus, left dorsal striatum and superior parietal lobule and bilateral cerebellum and inferior frontal gyrus after controlling for trait aggression and sex. Functional connectivity between the inferior frontal gyrus and caudate was also increased. No associations with resting state functional connectivity were found. Overall, the present study demonstrates an association between romantic jealousy and increased intensity ratings of angry faces as well as in activity and functional connectivity of dorsal striatal-inferior frontal circuitry. Thus, increased emotional responsivity to social threat and enhanced activity in limbic regions and dopaminergic fronto-striatal circuitry may be features of both non-morbid and pathological jealousy.
Upper bound on the biological effects of 50/60 Hz magnetic fields mediated by radical pairs
Authors: Hore P. J. 
Published: December 2018

AbstractProlonged exposure to weak (~1 μT) extremely-low-frequency (ELF, 50/60 Hz) magnetic fields has been associated with an increased risk of childhood leukaemia. One of the few biophysical mechanisms that might account for this link involves short-lived chemical reaction intermediates known as radical pairs. In this report, we use spin dynamics simulations to derive an upper bound of 10 parts per million on the effect of a 1 μT ELF magnetic field on the yield of a radical pair reaction. By comparing this figure with the corresponding effects of changes in the strength of the Earth’s magnetic field, we conclude that if exposure to such weak 50/60 Hz magnetic fields has any effect on human biology, and results from a radical pair mechanism, then the risk should be no greater than travelling a few kilometres towards or away from the geomagnetic north or south pole.
Single-cell analysis of Crohn’s disease lesions identifies a pathogenic cellular module associated with resistance to anti-TNF therapy
Authors: Martin JC , Boschetti G , Chang C , Ungaro R , Giri M , Chuang LS , Nayar S , Greenstein A , Dubinsky M. , Walker L , Leader A , Fine JS , Whitehurst CE , Mbow L , Kugathasan S , Denson L.A. , Hyams J. , Friedman JR , Desai P , Ko HM , Laface I , Akturk Guray , Schadt EE , Gnjatic S , Rahman A , Merad M , Cho JH , Kenigsberg E 
Published: December 2018

SummaryClinical benefits to cytokine blockade in ileal Crohn’s disease (iCD) have been limited to a subset of patients. Whether cellular and molecular heterogeneity contributes to variability in treatment responses has been unclear. Using single cell technologies combining scRNAseq, CyTOF and multiplex tissue imaging, we mapped the cellular landscape of inflamed ileum lesions, adjacent non-inflamed ileum and matched circulating blood cells of iCD patients. In inflamed tissues, we identified a pathogenic module characterized by an inflammatory mononuclear phagocyte (Inf.MNP)-associated cellular response organized around inflammatory macrophages and mature dendritic cells in a subset of iCD patients. We confirmed the Inf.MNP-associated cellular response in 4 independent iCD cohorts (n=441) and showed that presence of this pathogenic module at diagnosis correlated with primary resistance to anti-TNF therapy. Single cell mapping of iCD tissues identifies a complex cellular signature of anti-TNF resistance thereby revealing novel biomarkers of treatment response and tailored therapeutic opportunities.
Critical dynamics are a homeostatic set point of cortical networks in vivo
Authors: Ma Zhengyu , Turrigiano Gina G. , Wessel Ralf , Hengen Keith B. 
Published: December 2018

The brain is constantly challenged by severely destabilizing forces: proteins turn over rapidly, Hebbian modifications alter and introduce positive feedback into networks, and environments change over many timescales. Homeostatic plasticity mechanisms, which operate via negative feedback, are believed to compensate for these changes and constrain neuronal activity to a firing rate (FR) set point1,2,3. For decades, it has been widely assumed that activity in neural networks is robust as a direct result of the widespread expression of FR homeostasis1,4. Here we reveal that network dynamics are stabilized independent of excitatory FR homeostasis and that cortical networks actively self-organize around an ideal computational regime.We continuously tracked network spiking activity in the visual cortex (V1) of freely behaving rats for nine days. We found that, under baseline conditions, networks of excitatory neurons are robustly organized around criticality, a regime known to maximize information capacity and dynamic range. Monocular deprivation (MD) revealed a dissociation of excitatory FRs and network dynamics. MD immediately and severely disrupted network organization, which returned precisely to criticality over 48h. In contrast, both the excitatory FR drop and the subsequent FR recovery trailed the timecourse of network changes by more than 30h. Model investigations suggest a role for inhibitory neurons in maintaining critical dynamics. Collectively, these results show that complex activity in cortical circuits is actively maintained near criticality and that this organization is not explained by previously identified mechanisms of pyramidal neuron FR homeostasis.
Collection development practice in Indian Institute of Technology libraries of Eastern India: a study
Authors: Gulnaz  , Fatima Nishat 
Published: December 2018

Purpose
The purpose of this paper is to present the situation of collection development and management of Indian Institute of Technology (IIT) Guwahati and IIT Patna libraries. This research includes other areas of collection development, i.e. collection development policy, acquisition of resources, selection of resources and budget allocation. The collection management includes accessibility, stock verification, shelf arrangement, weeding out and library security of IIT Guwahati and IIT Patna Central Libraries.

Design/methodology/approach
A structured questionnaire was sent to the librarians via e-mail, which includes 20 questions with 103 preferences.

Findings
Present research has found that there is a difference in newly established IIT Patna library and old IIT Guwahati library in some aspects of collection development. In the library of IIT Patna, library committee is responsible for collection development policy as well as recommender of resource selection, whereas in IIT Guwahati library advisory committee is responsible for collection development policy and selection of resources on the recommendation of faculty members. The IIT Patna library is not facing any problem, while IIT Guwahati library facing many problems i.e., lack of funds, information explosion and literature scattered. The RFID is used in IIT Patna library, while in IIT Guwahati library it is under process.

Research limitations/implications
The study is limited to the collection development policies undertaken in IIT Patna and IIT Guwahati in eastern India. The research questions are limited to the theme only. Therefore, the findings of the study are not valid for an in-depth study.

Practical implications
The study has great importance for librarians of IITs which have recently established in India. The findings and suggestions can serve as groundwork and could help to solve some common problems that had been faced by them.

Originality/value
This is a comparative study of IIT Guwahati and IIT Patna libraries in eastern India. The collection development aspects, i.e. selection, acquisition, finance and collection management, play a vital role in the collection development to serve their users. The study can serve as a base for future studies in other academic and special libraries.
Government R&D subsidies, intellectual property rights protection and innovation
Authors: Deng Ping , Lu Hao , Hong Jin , Chen Qiong , Yang Yang 
Published: December 2018

Purpose
This paper aims to investigate whether a complementary effect exists between government R&D subsidies (GRSs) and intellectual property rights (IPR) protection on innovation performance in the pharmaceutical manufacturing industry in China. This paper also attempts to understand whether this complementary effect is significantly different across China’s eastern, central and western regions.

Design/methodology/approach
The study sample comprised 28 provinces involved in the pharmaceutical manufacturing industry in China from 2003 to 2014. Ordinary least squares was used to test the complementary effects of GRSs and IPR protection on innovation performance. The seemingly unrelated estimation test was also applied to ascertain whether differences existed between the eastern and western regions.

Findings
A complementary effect between GRSs and IPR protection in terms of improving the innovation of pharmaceutical manufacturers was found to exist only in eastern and western regions. There was no significant difference in the complementary effect between GRSs and IPR protection in terms of improving innovation among the three regions. Without considering the interaction effect of GRSs and IPR protection, the GRSs were negatively associated with innovation in the eastern region, but positively related to the innovation in central region.

Originality/value
This study contributes to the literature on government policies and innovation by incorporating the interaction effect of GRSs and IPR protection on innovation in the context of a high-tech industry (pharmaceutical manufacturing) in an emerging economy (China). It also explores the internal differences in the influence of this complementary effect on innovation in an emerging economy, enriching the institution-based view.
Data flows and national security: a conceptual framework to assess restrictions on data flows under GATS security exception
Authors: Ferracane Martina Francesca 
Published: December 2018

PurposeThe paper aims to explore the national security implications of a potential for a World Trade Organization (WTO) dispute on data flow restrictions. It proposes a basic conceptual framework to assess data flows’ restrictions under General Agreement on Trade in Services (GATS) security exception.Design/methodology/approachIf a case were to be brought before the WTO dispute settlement, the defender could support its case by invoking the security exception. This paper analyzes three main arguments that could be brought up: protection from cyber espionage, protection from cyberattacks on critical infrastructure and access to data needed to prevent terrorist threats. These three cases are analyzed both legally and technically to assess the relevance of restrictions on data flows under GATS security exception. This analysis can, more generally, inform the debate on the protection of national security in the digital era.FindingsIn the three cases, restrictions on data considered critical for national security might raise the cost of certain attacks. However, the risks would remain pervasive and national security would not be significantly enhanced both legally and technically. The implementation of good security standards and encryption techniques appears to be a more effective way to ensure a better response to cyber threats. All in all, it will be important to investigate on a case by case basis whether the scope of the measure (sectors and data covered) is considered proportionate and whether the measure in question in practice reduces the exposure of the country to cyber espionage, cyberattacks and terrorist threats.Originality/valueThis paper represents a contribution to the literature because it is the first paper to address systematically the issue of data flows and national security in the context of a GATS dispute and because it provides a unique perspective that looks both at legal and technical arguments.
Design-driven innovation: a systematic literature review
Authors: De Goey Heleen , Hilletofth Per , Eriksson Lars 
Published: December 2018

Purpose
The concept design-driven innovation focuses on innovating product meanings. It has been studied from a variety of perspectives and contexts since the early 2000s. However, a complete overview of the literature published in this area is currently missing. The purpose of this study is to provide a comprehensive understanding of how design-driven innovation contributes to value creation in product development.

Design/methodology/approach
In this systematic literature review, 57 papers and book chapters that cover design-driven innovation were identified and analyzed. An iterative coding process was followed to derive five facets of design-driven innovation that contribute to value creation.

Findings
Design-driven innovation creates value by focusing on the intangible values of products. The following five facets of design-driven innovation that contribute to value creation were identified: development of new product meanings, knowledge generation, actors and collaborations, capabilities and process. These facets and their interrelations are presented in a theoretical framework.

Practical implications
The main practical implication of this study is that it is now clear that the five facets of design-driven innovation are interrelated and reinforce each other. Therefore, companies need to approach design-driven innovation from a holistic perspective.

Originality/value
This paper contributes to theory by presenting the theoretical framework that provides an overview of available knowledge and that creates a context for future research.
The moderating effect of emotional intelligence on the relationship between supervisor conflict and employees’ counterproductive work behaviors
Authors: Ma Jie , Liu Cong 
Published: December 2018

PurposeResearch concludes that supervisor conflict is a primary antecedent of employee counterproductive work behaviors (CWBs). However, previous studies mainly focused on direct supervisor conflict, with indirect supervisor conflict understudied. To fill the research gap, the purpose of this study is to investigate the relationship between indirect supervisor conflict and employee CWBs and the buffering effect of emotional intelligence on indirect supervisor conflict–CWB relationships in two studies.Design/methodology/approachThe study used time-lagged design (Study 1) and longitudinal design (Study 2) with multisource data to test the theoretical model presented in this study.FindingsThe positive relationship between indirect supervisor conflict and CWBs were consistently supported with self-report CWBs but not with coworker-report CWBs. SEA and OEA were found to buffer the indirect supervisor conflict–CWB relationships with both self-report and coworker-report CWBs.Originality/valueThe study suggests that while covert and implicit, indirect supervisor conflict could drive employees to engage in CWBs that impose a threat to organization and its members. The emotional-appraisal aspect of emotional intelligence (i.e. SEA and OEA) could help employees to better cope with indirect supervisor conflict and mitigate employees’ engagement in CWBs.
Student–university identification and loyalty through social responsibility
Authors: El-Kassar Abdul-Nasser , Makki Dania , Gonzalez-Perez Maria Alejandra 
Published: December 2018

Purpose
The purpose of this paper is to highlight the value of university social responsibility (USR) by investigating its impact on student–university identification and student loyalty. It also examines the mediating effect of student–university identification and the moderating effect of the perceived importance of USR. A comparative study is also conducted between students from two diverse cultural backgrounds.

Design/methodology/approach
An online questionnaire was administered to students of universities in two different emerging markets economies (Lebanon and Colombia). The collected data were tested by applying descriptive techniques, cluster analysis and partial least square structural equation modeling with multi-group analysis using SmartPLS3.0 software.

Findings
The findings revealed that USR affects student loyalty both directly and indirectly through student–university identification.

Research limitations/implications
Assessing the model through a more varied sample population from different cultural backgrounds would entail more universal results and the ability to generalize the causality relationship between USR and student identification and loyalty.

Originality/value
This study is a valuable addition to the scarce literature on USR and its interplay with student–university identification. It presents USR as a vital marketing tool to achieve student identification and loyalty, being key factors that impact student enrollment and retention. It also translates into a competitive advantage for higher education institutions to overcome the fierce competition in the educational market. Additionally, this research can be considered a laboratory for theory testing and theory building due to its unique context and original primary data.
Continuing professional development: policies, practices and future directions
Authors: Masoumi Davoud , Hatami Javad , Pourkaremi Javad 
Published: December 2018

PurposeThe purpose of this paper is to focus on mapping the ways in which HE institutions enhance faculty members’ professional development. More precisely, by introducing a case from one of the well-established universities in Iran, the authors aim to examine the focus of faculty development (FD) activities and how FD is conducted, with a view to shedding light on the challenges of and disparities between faculty roles and areas of FD in higher education (HE) in Iran as a developing country.Design/methodology/approachIn order to explore and map the characteristics of FD and analyse the trends that Iranian HE institutions are experiencing in this area, a sequential explanatory multiple sources design, consisting of two distinct phases, was implemented (Creswell, 2012). In this design, the documents regarding the faculty professional development (decisions, agreements, The Job Structure Memorandum, and relevant documents and policies at the Iranian Ministry of Science, Research and Technology and the studied HE institution) were analysed first. Next, field records were collected by means of a series semi-structured interviews with faculty members in the given HE setting.FindingsThe analysis of the collected data brought to the surface three themes, namely, FD: policies and procedures, faculties professional development in practice, and associated challenges and future prospects. These initial findings helped to understand if and how FD activities occur as well as map the challenges and complexities in faculties’ CPD in Iranian HE. Further, it discusses possible solutions to develop relevant and practical professional development.Research limitations/implicationsThis case study is partly limited to a group of faculty members’ experiences and reflections on FD in one Iranian HE institution. Conducting additional surveys and observations with a large sample of the faculties and students may verify and consolidate the findings of the study and contribute to further insights on the ways faculties’ professional development can be transformed.Practical implicationsTaking into account the findings of the study, a dynamic framework for continued professional development of faculties in Iran is developed.Originality/valueThe findings of the study present valuable insights into the FD procedures, challenges and paradoxes that seem to shape FD in Iranian HE institutions. Moreover, the findings indicated much-needed structural modifications to simplify and harmonise the policies and procedures to harness profession development. To conclude, the initiatives and action plans that may contribute to FD and reshape the Iranian HE landscape is discussed. The applications and implications are also relevant for similar HE systems in developing countries.
The linkage between knowledge management practices and organization based projects for better learning outcome
Authors: Upadhyay Parijat , Paul Manas 
Published: December 2018

Purpose
The purpose of this paper is to provide a framework to understand and reflect upon issues, which can help in producing better industry-ready students graduating from business schools.

Design/methodology/approach
The paper examines research conducted in the area of knowledge management (KM) and proposes a conceptual framework that can be used by academic institutions to engage students and prepare them for industry needs so that they are better industry-ready graduates. A case study based approach has been adopted in this study.

Findings
In line with the literature-based analysis, a framework for better industry ready students has been proposed, illustrating the linkage between KM, learning from organization-based projects, industry feedback and inputs from international accreditation bodies in higher education.

Originality/value
This paper has provided a comprehensive framework that contributes to the understanding and refining the academic processes in a business school setting with the help of learning from academic KM process. Such a framework has not been previously developed by previous researchers.