bluuebunny/crossref_metadata_2025_split huggingface dataset:
VAMP8 contributes to TRIM6-mediated type-I interferon antiviral response during West Nile virus infection
Authors: van Tol Sarah , Atkins Colm , Bharaj Preeti , Johnson Kendra N. , Hage Adam , Freiberg Alexander N. , Rajsbaum Ricardo 
Published: August 2019

ABSTRACTSeveral members of the tripartite motif (TRIM) family of E3 ubiquitin ligases regulate immune pathways including the antiviral type I interferon (IFN-I) system. Previously, we demonstrated that TRIM6 is involved in IFN-I induction and signaling. In the absence of TRIM6, optimal IFN-I signaling is reduced, allowing increased replication of interferon-sensitive viruses. Despite having evolved numerous mechanisms to restrict the vertebrate host’s IFN-I response, West Nile Virus (WNV) replication is sensitive to pre-treatment with IFN-I. However, the regulators and products of the IFN-I pathway that are important in regulating WNV replication are incompletely defined. Consistent with WNV’s sensitivity to IFN-I, we found that in TRIM6 knockout (TRIM6-KO) A549 cells WNV replication is significantly increased and IFN-I induction and signaling is impaired compared to wild-type (wt) cells. IFNβ pre-treatment was more effective in protecting against subsequent WNV infection in wt cells as compared to TRIM6-KO, indicating that TRIM6 contributes to the establishment of an IFN-induced antiviral response against WNV. Using next generation sequencing, we identified VAMP8 as a potential factor involved in this TRIM6-mediated antiviral response. VAMP8 knockdown resulted in reduced Jak1 and STAT1 phosphorylation and impaired induction of several ISGs following WNV infection or IFNβ treatment. Furthermore, VAMP8-mediated STAT1 phosphorylation required the presence of TRIM6. Therefore, the VAMP8 protein is a novel regulator of IFN-I signaling, and its expression and function is dependent on TRIM6 activity. Overall, these results provide evidence that TRIM6 contributes to the antiviral response against WNV and identified VAMP8 as a novel regulator of the IFN-I system.IMPORTANCEWNV is a mosquito-borne flavivirus that poses threat to human health across large discontinuous areas throughout the world. Infection with WNV results in febrile illness, which can progress to severe neurological disease. Currently, there are no approved treatment options to control WNV infection. Understanding the cellular immune responses that regulate viral replication is important in diversifying the resources available to control WNV. Here we show that the elimination of TRIM6 in human cells results in an increase in WNV replication and alters the expression and function of other components of the IFN-I pathway through VAMP8. Dissecting the interactions between WNV and host defenses both informs basic molecular virology and promotes the development of host- and viral-targeted antiviral strategies.
Crystal structure of UDP-glucose pyrophosphorylase fromYersinia pestis, a potential therapeutic target against plague
Authors: Gibbs Morgan E. , Lountos George T. , Gumpena Rajesh , Waugh David S. 
Published: August 2019

Yersinia pestis, the causative agent of bubonic plague, is one of the most lethal pathogens in recorded human history. Today, the concern is the possible misuse ofY. pestisas an agent in bioweapons and bioterrorism. Current therapies for the treatment of plague include the use of a small number of antibiotics, but clinical cases of antibiotic resistance have been reported in some areas of the world. Therefore, the discovery of new drugs is required to combat potentialY. pestisinfection. Here, the crystal structure of theY. pestisUDP-glucose pyrophosphorylase (UGP), a metabolic enzyme implicated in the survival ofY. pestisin mouse macrophages, is described at 2.17 Å resolution. The structure provides a foundation that may enable the rational design of inhibitors and open new avenues for the development of antiplague therapeutics.
Probiotic creamy soy sauce with Lactobacillus plantarum BG 112
Authors: Moraes Filho Marsilvio Lima , Busanello Marli , Garcia Sandra 
Published: August 2019

Purpose
The purpose of this paper is to apply okara flour in the elaboration of a product, verifying the effect of the fermentation by Lactobacillus plantarum BG 112 on the antihypertensive activity and to develop probiotic sauce with gums and low lipid content.

Design/methodology/approach
During the fermentation process, the inhibitory activity of angiotensin-converting enzyme (ACE) and production of organic acids were determined. The simplex-centroid mixture of guar gum, xanthan gum and pregelatinized cassava starch was used for studying the variables water holding capacity, viscosity and firmness. Counts of probiotics and in vitro survival of probiotics in simulated gastrointestinal conditions were made.

Findings
The fermented soymilk showed ACE inhibition capacity above 50 percent with 32 h of fermentation, increasing the levels of lactic acid and acetic acid progressively. Based on the regression analysis and response surfaces, the binary mixture with guar gum and xanthan was chosen as the most suitable for the formulation of the sauce, having over 30 days of storage counts above 8.5 log CFU.g−1 and above 6 log CFU.g−1 after simulation of gastrointestinal conditions. The global acceptance was 7.0 corresponding to the moderately liked.

Practical implications
The findings suggest that the sauce developed has been well accepted by potential consumers and can be incorporated into the diet and can result in health benefits for the consumer when regularly ingested. The fermentation process of soymilk promoted an increase in antihypertensive capacity. Despite the reduction in viable cell counts throughout storage, counts remained high in the product, having a high survival rate after exposure under simulated gastrointestinal conditions.

Originality/value
The use of okara flour in the diet is viable and helps to improve the nutritional composition of foods. The use of okara flour in sauce showed potential applicability and could be incorporated into different products. The fermentation process of soymilk with okara flour produces benefits beyond the sensorial characteristics. The elaborated probiotic sauce presented physical–chemical and microbiological stability throughout the storage, being an alternative for people with food restrictions.
Evaluating PDA using financial analysis for streaming videos: a case study at a US academic library
Authors: Falloon Kerry A. 
Published: August 2019

Purpose
The purpose of this study is to evaluate the pre and post success of patron-driven acquisition (PDA) streaming video projects using financial analysis, thus comparing PDA as a collection building tool against other legacy purchasing practices.

Design/methodology/approach
This is primarily a quantitative study based on deductive data derived; however, it does include qualitative findings. Hence, it is a mixed study.

Findings
The study approaches this topic from the viewpoint that ongoing evaluations of PDA projects, based on savings and benefits derived, can be practically conducted and are useful for CD decision-making by purchasing agents in academic libraries.

Research limitations/implications
Caution should be used when generalizing this study due to its specificity of its library’s collection development (CD) needs and methodology. The study is not intended to be original research, but it builds upon other case studies in this area.

Practical implications
In addition to improving CD strategies, libraries could use this study to develop a financial valuation methodology, which can help guide purchasing practices.

Social implications
This study has implications to all library stakeholders.

Originality/value
Few studies have compared and analyzed streaming video PDA programs using financial analysis in a practical manner to aid library acquisitions.
Trust, distrust and translation in a disaster
Authors: Cadwell Patrick 
Published: August 2019

PurposeThe purpose of this paper is to describe, explain and provide context for relationships between translation, trust and distrust using accounts of the 2011 Great East Japan Earthquake given by foreign residents who experienced the disaster.Design/methodology/approachThis research provides a qualitative analysis of ethnographic interview data drawn from a broader study of communication in the 2011 disaster using the cases of 28 foreign residents of the disaster zone from 12 different countries of origin.FindingsThe study confirms the general importance, the linguistic challenges and the context dependency of trust in disaster-related communication at the response phase. It found that translation was involved in some trust reasoning carried out by foreign residents and that translation was anad hocact undertaken by linguistically and culturally proficient acquaintances and friends.Research limitations/implicationsThe research examines a limited range of trust phenomena and research participants: only reason-based, social trust described by documented foreign residents of the 2011 disaster zone in Japan was considered. Furthermore, generalisations from the case study data should be approached with caution.Originality/valueThis paper adds to the literature on trust and disaster response as opposed to trust and disaster preparedness, which has already been comprehensively studied. It responds to calls for more studies of the role of context in the understanding of trust and for greater attention to be paid in research to relationships between trust and other phenomena.
Entrepreneurial orientation and innovation performance: insights from Korean ventures
Authors: Seo Ribin 
Published: August 2019

PurposeThe purpose of this paper is to explore the curvilinear relationship between entrepreneurial orientation (EO) and innovation performance in ventures of Korea, where this topic has been unexplored.Design/methodology/approachThis study used 1,837 ventures’ responses in a panel data of the 2015 Korea’s Venture Business Investigation Survey. The measurements of EO based on the Miller/Covin and Slevin scale were used from the survey. The author adopted and independently measured three different indicators of innovation performance: technology innovation, product innovation and sales growth.FindingsThe results of the regression analysis show the significant curvilinear relationships of EO with technology innovation and product innovation, while the relationship between EO and sales growth remains linear. The author also found that multiplicative EO construct explains the changes inR2better than the summative EO construct for the improvement of innovations in technology and product.Originality/valueThis paper provides empirical evidence on the EO–innovation performance relationships from Korean ventures – an underexplored area of research. It also takes into account the curvilinear relationships of summative and multiplicative EO constructs with different performance indicators. Future research can benefit from the use of the multiplicative EO estimation and multiple performance indicators to capture a clearer picture of the causal relationships.
A socio-technical analysis of internet of things development: an interplay of technologies, tasks, structures and actors
Authors: Ghaffari Kimia , Lagzian Mohammad , Kazemi Mostafa , Malekzadeh Gholamreza 
Published: August 2019

Purpose
Prior research on the area of internet of things (IoT) development has primarily emphasized the overview descriptions and rarely investigated this area from a socio-technical standpoint. However, IoT development is a socio-technical ensemble, which requires analysis with a simultaneous focus on both technical and non-technical issues. Hence, this paper aims to analyze the development of IoT through the lens of the socio-technical system (STS) theory.

Design/methodology/approach
Having reviewed the STS theory, the key components of the IoT development are identified using prior literature review and semi-structured interviews with experts involved in the Iranian IoT development effort.

Findings
As a result, this paper provides insight into the key socio-technical issues in the IoT development classified under technology, tasks, structure and actors as four components of STS. Moreover, the close connections between the components are clarified.

Originality/value
This research is among the earliest studies, which use the STS theory to investigate the IoT development. The conducted socio-technical analysis of this study may assist the governments, industries and entrepreneurs as the chief stakeholders of IoT development to better align their actions with each other and achieve a balance between both technical and social sides.
Double-faced shading effect based on two wefts full-backed structure for traditional weft-backed woven fabrics
Authors: Bai Linlin , Zhou Jiu 
Published: August 2019

Purpose
The purpose of this paper, on innovative design of traditional weft-backed woven fabric, is to investigate a design principle and method for full-backed structure with double-faced shading effect to realize two types of double-faced shading effects for traditional weft-backed fabric that are impossible to be realized under plane design mode. In addition, the study on the color rendering law is conducive to the design application, and the effectiveness of the design method has been verified by the design practices.

Design/methodology/approach
This paper presents a design method for full-backed structure with two shaded weave databases (SWDs) by selecting two primary weaves (PWs), establishing the corresponding SWDs, selecting the proper compound structures for database of full-backed structure with double-faced shading effect. Color card fabric with 544 specimens is produced and their color values are measured, their color difference and variance are analyzed to evaluate the color rendering characteristics. Finally, double-faced weft-backed fabrics are produced under layered-combination design mode to verify the practicality of full-backed structure with double-faced shading effect.

Findings
Weft-backed woven fabrics with “SPDC” (same pattern and different color) and “DPDC” (different pattern and different color) shading effects can be produced using full-backed structure with double-faced shading effect. The color expression is extremely enhanced (136 compound structures on one side for one color weft). In the shading process, two sets of wefts do not affect each other, and stable and ideal color shading effect with high color purity can be expressed according to the analyses on the L* (lightness) values, color purity, color differences (0.47–3.20) and variance (0.25–1.21) of the color card fabric.

Originality/value
Breaking through the structural limitations and achieving the double-faced shading effects that cannot be expressed in plane design mode. The research on two weft-backed fabric with the most basic weft-backed structure provides not only a theoretical base for further study on weft-backed structures, but also some references for structure innovation design of traditional weft-backed woven fabrics.
Constrained choice in supply chain relationships: the effects of regulatory institutions
Authors: Davis Donna F. , Davis-Sramek Beth , Golicic Susan L. , McCarthy-Byrne Teresa M. 
Published: August 2019

PurposeUtilizing a top-down approach of middle-range theorizing (MRT), the purpose of this paper is to integrate relational exchange with institutional theory to examine how companies manage supply chain relationships to achieve desired supply chain outcomes in industries characterized by varying degrees of regulatory mandates that restrict the choice of supply chain partners. The authors identify this supply chain relationship dynamic as constrained choice.Design/methodology/approachA moderated mediation model is tested using survey data from producers in the US wine industry to investigate the effects of regulatory pressure on the ability of wine producers to achieve operational coordination when responding to relational behaviors through either trust or calculative commitment.FindingsResults find that relational behaviors can improve operational coordination through two distinct paths: trust or calculative commitment. With the moderating effect of regulatory pressure, relational behaviors more effectively facilitate operational coordination through trust. Alternately, regulatory pressure attenuates the mediated relationship through calculative commitment.Research limitations/implicationsThe research introduces constrained choice dynamics into the supply chain relationship literature via MRT. Integrating generative mechanisms from relational exchange and institutional theories provides theoretical depth and context-specific knowledge about relationships that operate in constrained choice situations.Practical implicationsManagers impacted by constrained choice should recognize that mechanisms typically resulting in positive relationship outcomes may respond differently in the presence of regulatory constraints. With greater regulatory pressure, efforts to enhance operational coordination are more effective using relational mechanisms to build trust. When trust is diminished, calculative commitment can be effective in achieving operational coordination, although extensive regulations make it more difficult.Originality/valuePrevious research traditionally assumes that managers are free to select suitable trading partners that ensure mutually beneficial relationships. The research develops a middle-range theory examining the constrained choice dynamic in relationships that are impacted to varying degrees by regulatory institutions.
Fraud risk factors and tendency to commit fraud: analysis of employees’ perceptions
Authors: Anindya Jesi Rizky , Adhariani Desi 
Published: August 2019

Purpose This study aims to determine the fraud risk factors perceived by employees to have the greatest influence on individuals committing fraud as an unethical conduct, as well as to analyze employees’ opinions on fraud prevention program.

Design/methodology/approach The fraud risk factors in this study are based on the concept of the fraud triangle as developed by Donald Cressey, as well as examples of situations set out in SAS No. 99. The samples used in this study are company employees who have been selected using the convenience sampling method.

Findings A survey of 109 employees reports that none of the three factors (pressure, opportunity and rationalization) has a significant influence on fraud. However, when comparing the factors, the pressure is considered to have the highest impact. In terms of fraud prevention, the employees suggest that it is extremely important to implement all prevention tools, especially with regard to the adequate segregation of duties.

Research limitations/implications Limitations of this study in terms of method and small samples are expected to inform future studies to overcome the limitations by using other methods such as interview and by collecting more respondents to gather their perceptions and opinions.

Originality/value This study contributed to the literature in confirming the pressure as the dominant factor and in confirming the importance of anti-fraud programs as suggested by the agency theory.
Efficacy of weather index insurance for mitigation of weather risks in agriculture
Authors: Singh Pankaj , Agrawal Gaurav 
Published: August 2019

PurposeThe purpose of this paper is to review research on weather index insurance (WII) for mitigating the weather risk in agriculture and to identify research gaps in current available literature through integrative review.Design/methodology/approachThis paper is based on the integrative review method as proposed by Whittemore and Knafl. QualSysts tool was adopted for assessing the quality appraisal of articles. Reporting followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines.FindingsDetailed critical analysis of content reveals that WII studies are growing and shifting from traditional to the newest themes. Efficacy of WII is significantly influenced by the impacts of climate change. This paper generates a conceptual framework by synthesizing the published literature on WII.Research limitations/implicationsThis paper will be used to improve the WII practices and influence public policy. It is also beneficial in research by contributing to the systematic body of knowledge and useful for researchers to analyze the past and present status with future prospects of further studies on WII.Originality/valueThe paper is the original work of the author. To the best of authors’ knowledge, this is the first paper on integrative review on the efficacy of WII. An attempt has been made in the current paper to critically examine the studies of WII.
Building legitimacy for European public sector accounting standards (EPSAS)
Authors: Dabbicco Giovanna , Steccolini Ileana 
Published: August 2019

PurposeThe purpose of this paper is to look at the European public sector accounting standards (EPSAS) project development path to explore how governance and legitimacy issues intertwine when a new standard-setting system is developed.Design/methodology/approachA qualitative interpretative multimethod approach is adopted, which encompasses document analysis and participative observations.FindingsThe analysis shows the role of governance dimensions, including institutional participation and consensus, in the process for securing the legitimacy of accounting standards and the related setting processes, pointing to the critical issues emerging throughout the development of the EPSAS project.Originality/valueThe definition of public sector accounting standards poses significant challenges to the accounting profession and regulators alike. A paradigmatic case of such challenges is represented by the decisions to develop harmonised EPSAS. A key contribution of this paper is to connect legitimacy dimensions with network governance, offering a view of the input, output and procedural dimensions associated with decisions to legitimise EPSAS and how these may be affected by network governance.
From West to East: British sojourners’ acculturation in China
Authors: Yu Qionglei , Yen Dorothy A. , Cappellini Benedetta , Wang Cheng Lu 
Published: August 2019

Purpose
The previous literature has often focussed on Asian migrants’ acculturation to western cultures with data collected in the western contexts. The purpose of this paper is to explore western consumers’ acculturation to East Asian cultures and their consumption behaviour, which fulfils the research scarcity in this area.

Design/methodology/approach
This study was conducted via carrying out in-depth interviews with 18 British sojourners in China, exploring how they acculturated to Chinese culture, with a particular focus on their food and media consumption choices. This study applied inductive qualitative data analysis to build on but explore beyond existing theory.

Findings
The findings show that British consumers display a diversified acculturation strategy towards different products. They present an integrative approach to food consumption with a negotiable identity to host culture value whilst they adopt a separated approach relating to traditional media consumption, showing a non-negotiable consumption stance. They apply an assimilated approach for pragmatic reasons in terms of social media adoption.

Originality/value
British sojourners in China hold a different cultural stance in different areas of consumption. The study contributes to existing theory by arguing the complexity of a continuous negotiation process between different value systems in sojourning consumers’ consumption choices, which existing acculturation models have not yet examined. By emphasising the context speciality, the findings give marketers clear marketing implications when targeting sojourning consumers who declare their value stance via consumption practice.