bluuebunny/crossref_metadata_2025_split huggingface dataset:
ДО ПИТАННЯ МАКРО-, МІКРОДІАГНОСТИКИ ГАРБУЗА НАСІННЯ ЯК ЛІКАРСЬКОЇ РОСЛИННОЇ СИРОВИНИ
Authors: Vovk O. , Sokolova O. , Кotov S. , Gontova T. , Kotov A. 
Published: June 2018

Мета роботи. Вивчення діагностичних макроскопічних і мікроскопічних ознак сировини гарбуза насіння для розробки відповідних розділів національної монографії «Гарбуза насіння».Матеріали і методи. Об’єкти дослідження – 7 серій ЛРС гарбуза насіння, зібрані в різних районах Харківської області. Макроскопічні ознаки вивчали неозброєним оком і за допомогою лупи (збільшення х10), мікроскопічне дослідження проводили за допомогою бінокулярного мікроскопа БМ-51-2 і світлового мікроскопа «Биолам ЛОМО».Результати й обговорення. Проаналізовано зміст інформації щодо обраного об’єкта у фармакопеях (ДФ ХІ, ДФ РБ, ВНР, DAB 10) та інших наукових джерелах. Виявлено, що розділ «Макроскопія» включає: опис зовнішніх – морфологічних, якісних і кількісних характеристик насіння; характеристику насінної шкірки; монографія ВНР підкреслює, що зріла насінина гарбуза не має ендосперму; надає опис будови зародку. Аналіз розділу «Мікроскопія» свідчить, що всі аналізовані фармакопеї майже однотипно описують характерні риси будови тканин досліджуваної ЛРС на поперечному зрізі насінини.Експериментально досліджено важливі для стандартизації діагностичні макроскопічні ознаки 7 серій сировини: забарвлення, форма, розміри насінин; поверхня насінин; будова насінної шкірки; зародок.Експериментально досліджено важливі для стандартизації діагностичні мікроскопічні ознаки 7 серій сировини. На поперечному зрізі зрілої насінини гарбуза діагностичними є: тканини насінної шкірки, алейронового шару і сім’ядолі. Визначено відповідність досліджуваної сировини вимогам зазначених фармакопей.Висновки. На основі виконаної роботи розроблено проект розділів «Ідентифікація А» та «Ідентифікація В» до національної монографії «Гарбуза насіння»N.
СИНТЕЗ ТА ПЕРВИННА ОЦІНКА ПРОТИЗАПАЛЬНОЇ АКТИВНОСТІ 1,4,5,6-ТЕТРАГІДРОПІРИМІДИН-2-КАРБОКСАМІДІВ
Authors: Horishny V. Ya. , Frolov D. A. , Nektegayev I. O. , Ostapiuk Yu. V. , Matiychuk V. S. 
Published: June 2018

Мета роботи. Розробити методики отримання ряду нових морфолін-4-іл-2-тіоксоацетамідів та дослідити їх взаємодію з 1,3-диамінопропаном. Здійснити синтез нових 1,4,5,6-тетрагідропіримідин-2-карбоксамідів та провести первинний скринінг їх протизапальних властивостей.Матеріали і методи. Органічний синтез, спектроскопія ЯМР, елементний аналіз, фармакологічний скринінг.Результати й обговорення. Взаємодією хлороацетамідів, синтезованих на основі заміщених анілінів та 2-аміно-5-бензилтіазолів, з сіркою та морфоліном отримано ряд нових морфолін-4-іл-2-тіоксоацетамідів. Встановлено, що їх взаємодія з 1,3-діамінопропаном приводить до утворення 1,4,5,6-тетрагідропіримідин-2-карбоксамідів. Досліджено протизапальну активність деяких синтезованих сполукВисновки. Розроблено методику синтезу 1,4,5,6-тетрагідропіримідин-2-карбоксамідів. За результатами дослідження протизапальної активності синтезованих похідних ідентифіковано високоактивні сполуки, які з показниками пригнічення запальної реакції в межах 37,5–46,7 % співмірні з дією еталонного нестероїдного протизапального засобу «Диклофенаку натрію».
Hypoalphalipoproteinemia and
BRAF
V600E
Mutation Are Major Predictors of Aortic Infiltration in the Erdheim-Chester Disease
Authors: Cohen-Aubart Fleur , Guerin Maryse , Poupel Lucie , Cluzel Philippe , Saint-Charles Flora , Charlotte Frédéric , Arsafi Youssef , Emile Jean-François , Frisdal Eric , Le Goff Carine , Donadieu Jean , Amoura Zahir , Lesnik Philippe , Haroche Julien , Le Goff Wilfried 
Published: June 2018

Objective—
Erdheim-Chester disease (ECD) is a rare non-Langerhans cell histiocytosis characterized by the infiltration of multiple tissues with lipid-laden histiocytes. Cardiovascular involvement is frequent in ECD and leads to a severe prognosis. The objective of this study was to determine whether an alteration of lipid metabolism participates in the lipid accumulation in histiocytes and the cardiovascular involvement in ECD.

Approach and Results—

An analysis of plasma lipid levels indicated that male ECD patients carrying the
BRAF
V600E
(B-Raf proto-oncogene, serine/threonine kinase) mutation exhibited hypoalphalipoproteinemia, as demonstrated by low plasma HDL-C (high-density lipoprotein cholesterol) levels. Capacity of sera from male
BRAF
V600E
ECD patients to mediate free cholesterol efflux from human macrophages was reduced compared with control individuals. Cardiovascular involvement was detected in 84% of the ECD patients, and we reported that the presence of the
BRAF
V600E
mutation and hypoalphalipoproteinemia is an independent determinant of aortic infiltration in ECD. Phenotyping of blood CD14
+
cells, the precursors of histiocytes, enabled the identification of a specific inflammatory signature associated with aortic infiltration which was partially affected by the HDL phenotype. Finally, the treatment with vemurafenib, an inhibitor of the
BRAF
V600E
mutation, restored the defective sera cholesterol efflux capacity and reduced the aortic infiltration.

Conclusions—

Our findings indicate that hypoalphalipoproteinemia in male ECD patients carrying the
BRAF
V600E
mutation favors the formation of lipid-laden histiocytes. In addition, we identified the
BRAF
status and the HDL phenotype as independent determinants of the aortic involvement in ECD with a potential role of HDL in modulating the infiltration of blood CD14
+
cells into the aorta.
Association of Blood Pressure Measurements With Peripheral Artery Disease Events
Authors: Itoga Nathan K. , Tawfik Daniel S. , Lee Charles K. , Maruyama Satoshi , Leeper Nicholas J. , Chang Tara I. 
Published: June 2018

Background:
Current guidelines recommend treating hypertension in patients with peripheral artery disease (PAD) to reduce the risk of cardiac events and stroke, but the effect of reducing blood pressure on lower extremity PAD events is largely unknown. We investigated the association of blood pressure with lower extremity PAD events using data from the ALLHAT trial (Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial).

Methods:
ALLHAT investigated the effect of different antihypertensive medication classes (chlorthalidone, amlodipine, lisinopril, or doxazosin) on cardiovascular events. With the use of these data, the primary outcome in our analysis was time to first lower extremity PAD event, defined as PAD-related hospitalization, procedures, medical treatment, or PAD-related death. Given the availability of longitudinal standardized blood pressure measurements, we analyzed systolic blood pressure (SBP), diastolic blood pressure (DBP), and pulse pressure as time-varying categorical variables (reference categories 120–129 mm Hg for SBP, 70–79 mm Hg for DBP, and 45–54 mm Hg for pulse pressure) in separate models. We used extended Cox regression with death as a competing risk to calculate the association of each blood pressure component with PAD events, and report the results as subdistribution hazard ratios and 95% CIs.

Results:

The present analysis included 33 357 patients with an average age of 67.4 years, 53.1% men, 59.7% white race, and 36.2% with diabetes mellitus. The median baseline blood pressure was 146/84 mm Hg. Participants were followed for a median of 4.3 (interquartile range, 3.6–5.3) years, during which time 1489 (4.5%) had a lower extremity PAD event, and 4148 (12.4%) died. In models adjusted for demographic and clinical characteristics, SBP <120 mm Hg was associated with a 26% (CI, 5%–52%;
P
=0.015) higher hazard and SBP≥160 mm Hg was associated with a 21% (CI, 0%–48%;
P
=0.050) higher hazard for a PAD event, in comparison with SBP 120 to 129 mm Hg. In contrast, lower, but not higher, DBP was associated with a higher hazard of PAD events: for DBP <60 mm Hg (hazard ratio, 1.72; CI, 1.38–2.16). Pulse pressure had a U-shaped association with PAD events.

Conclusions:
In this reanalysis of data from ALLHAT, we found a higher rate of lower extremity PAD events with higher and lower SBP and pulse pressure and with lower DBP. Given the recent revised blood pressure guidelines advocating lower SBP targets for overall cardiovascular risk reduction, further refinement of optimal blood pressure targets specific to PAD is needed.

Clinical Trial Registration:

URL:
https://www.clinicaltrials.gov
. Unique identifier: NCT00000542.
Cyclooxygenase-2, Asymmetric Dimethylarginine, and the Cardiovascular Hazard From Nonsteroidal Anti-Inflammatory Drugs
Authors: Ricciotti Emanuela , Castro Cecilia , Tang Soon Yew , Briggs William T.E. , West James A. , Malik Dania , Rhoades Seth D. , Meng Hu , Li Xuanwen , Lahens Nicholas F. , Sparks Jeffrey A. , Karlson Elizabeth W. , Weljie Aalim M. , Griffin Julian L. , FitzGerald Garret A. 
Published: June 2018

Background:
Large-scale, placebo-controlled trials established that nonsteroidal anti-inflammatory drugs confer a cardiovascular hazard: this has been attributed to depression of cardioprotective products of cyclooxygenase (COX)–2, especially prostacyclin. An alternative mechanism by which nonsteroidal anti-inflammatory drugs might constrain cardioprotection is by enhancing the formation of methylarginines in the kidney that would limit the action of nitric oxide throughout the vasculature.

Methods:

Targeted and untargeted metabolomics were used to investigate the effect of COX-2 deletion or inhibition in mice and in osteoarthritis patients exposed to nonsteroidal anti-inflammatory drugs on the
l
-arginine/nitric oxide pathway.

Results:

Analysis of the plasma and renal metabolome was performed in postnatal tamoxifen-inducible Cox-2 knockout mice, which exhibit normal renal function and blood pressure. This revealed no changes in arginine and methylarginines compared with their wild-type controls. Moreover, the expression of genes in the
l
-arginine/nitric oxide pathway was not altered in the renal medulla or cortex of tamoxifen inducible Cox-2 knockout mice. Therapeutic concentrations of the selective COX-2 inhibitors, rofecoxib, celecoxib, and parecoxib, none of which altered basal blood pressure or renal function as reflected by plasma creatinine, failed to elevate plasma arginine and methylarginines in mice. Finally, plasma arginine or methylarginines were not altered in osteoarthritis patients with confirmed exposure to nonsteroidal anti-inflammatory drugs that inhibit COX-1 and COX-2. By contrast, plasma asymmetrical dimethylarginine was increased in mice infused with angiotensin II sufficient to elevate blood pressure and impair renal function. Four weeks later, blood pressure, plasma creatinine, and asymmetrical dimethylarginine were restored to normal levels. The increase in asymmetrical dimethylarginine in response to infusion with angiotensin II in celecoxib-treated mice was also related to transient impairment of renal function.

Conclusions:
Plasma methylarginines are not altered by COX-2 deletion or inhibition but rather are elevated coincident with renal compromise.
Sequential Hybrid Therapy With Pulmonary Endarterectomy and Additional Balloon Pulmonary Angioplasty for Chronic Thromboembolic Pulmonary Hypertension
Authors: Yanaka Kenichi , Nakayama Kazuhiko , Shinke Toshiro , Shinkura Yuto , Taniguchi Yu , Kinutani Hiroto , Tamada Naoki , Onishi Hiroyuki , Tsuboi Yasunori , Satomi‐Kobayashi Seimi , Otake Hiromasa , Tanaka Hiroshi , Okita Yutaka , Emoto Noriaki , Hirata Ken‐ichi 
Published: June 2018

Background

Residual symptoms after pulmonary endarterectomy (
PEA
) remain as the clinical issues to be solved. Additional balloon pulmonary angioplasty (
BPA
) after
PEA
showed its efficacy with symptoms in a case series, although long‐term spontaneous recovery of exercise ability after
PEA
was also reported. However, no studies have validated the clinical efficacy of additional
BPA
by directly comparing PEA with and without
BPA
. The aim of this study was to retrospectively evaluate the efficacy of additional
BPA
as a sequential hybrid therapy for chronic thromboembolic pulmonary hypertension after
PEA
.

Methods and Results

Among 44 patients with chronic thromboembolic pulmonary hypertension, 20 patients had residual symptoms after PEA. Of those, 10 patients underwent additional
BPA
(hybrid group) and were compared with the other 10 patients, who were followed up without
BPA
(
PEA
group). The period from
PEA
to additional
BPA
was 7.3±2.3 months. In hybrid group, mean pulmonary arterial pressure was significantly improved by
PEA
(40.6±1.8 to 26.9±3.1 mm Hg,
P
=0.001) and improved further (to 16.7±1.8 mm Hg,
P
=0.002) with additional
BPA
, which resulted in remarkable improvement in World Health Organization (
WHO
) functional class (pre‐ to post‐BPA: class I/
II
/
III
/
IV
, 0/5/4/1 to 7/3/0/0;
P
<0.001). Compared with the
PEA
group at follow‐up, the hybrid group achieved better mean pulmonary arterial pressure (18.7±1.7 versus 30.2±3.2 mm Hg,
P
=0.008),
WHO
functional class (class I/
II
/
III
/
IV
, 7/3/0/0 versus 0/8/2/0;
P
=0.001), and 6‐minute walking distance (429±38 versus 319±22 m,
P
=0.028).

Conclusions

A sequential hybrid strategy improved residual symptoms and exercise capacity compared with single‐
PEA
therapy.
The State, Zionism and the Nazi Genocide
Authors: Englert Sai 
Published: June 2018

AbstractThis paper explores contemporary Jewish identity-formation and the centrality of official Holocaust memory and Zionism – understood as the ongoing settler-colonial project aiming at the formation and maintenance of a Jewish-exclusivist state in Palestine – to this process. It argues that identity politics within the Jewish community are based on an understanding of identity, which assumes it to be static and individual. In doing so, this political approach reproduces the essentialisation of Jewish communities under the banner of Zionism and official state history. The paper aims to show how this process of identification between Judaism, official Holocaust memory and Zionism has been a state-led process, rooted in the historical development of antisemitism and European colonialism. In order to do so, it builds on a critique of classical Marxist analyses of the Jewish question. It finally proposes a more fluid approach to identity, which understands it as socially constructed, contested, and subject to political contestation.
ASEAN People-to-People Connectivity
Authors: Fornalé Elisa 
Published: June 2018

Abstract
The concept of intra-regional connectivity is emerging as the rationale for the ASEAN regional project and will develop around three pillars: the physical infrastructure, the institutions and the people. Specifically, the facilitation of the free movement of highly skilled migrant workers at the regional level is identified in ASEAN documents as a primary mechanism to achieve people-to-people connectivity. The paper aims to study the emerging regional mobility framework under ASEAN by focusing attention on the potential impact of mutual recognition arrangements (MRAs) on professional services as connecting instruments. The objective is to provide new insights into the building of ASEAN’s regional process by taking the mutual recognition regime as a means to reconcile the traditional prerogatives of sovereignty and new common concerns in the context of cross-border human mobility and economic development. The review of the current evolution of ASEAN MRA architecture will focus on the challenges and promises of the intra-regional cooperation in developing the legal framework by fostering a rule-based organisation. To this end, the analysis will be complemented by an examination of Thailand’s mutual recognition initiatives for professionals in the health services.
Dreams and Christian Conversion: Gleanings from a Pentecostal Church Context in Nepal
Authors: Sears Robert E. 
Published: June 2018

AbstractDespite consideration from missiologists studying Muslim-to-Christian conversion, the role of dreams in contemporary Christian conversion has not received widespread attention. Additionally, though researchers have frequently noted the use of dreams among Pentecostal/charismatic Christians, this finding stands in need of exploration vis-à-vis the concept of conversion. This study will address each of these issues and further the general understanding of the role of dreams in Christian conversion by examining this topic in contemporary Nepal, a predominantly Hindu nation with a rapidly growing, extensively Pentecostal/charismatic Christian community. Relying on data from a combination of surveys, interviews, and participant observation, this study discusses the prevalence, preconditions, processes, and impact of dream-related conversion vis-à-vis a Pentecostal church context in Nepal.
Songs that Carry Transformation: Pentecostal Praise and Worship Rituals in Nairobi, Kenya
Authors: Prosén Martina 
Published: June 2018

AbstractIn this article, the theological meaning of transformation is examined from the vantage point of a local Pentecostal church in Nairobi, Kenya, and its liturgical practices. The church under study is the Woodley branch of Christ is the Answer Ministries (CITAMWoodley), formerly Nairobi Pentecostal Church (NPC) Woodley, and data was collected through field research. Arguing with the help of Steven Land’s standard workPentecostal Spirituality. A Passion for the Kingdom, it is demonstrated that praise and worship rituals function as vehicles for transformation in the theology/spirituality of the informants. Singing and making music are not optional or random activities, but constitute a core ritual providing congregants a viable route to a central goal of Pentecostal spirituality: transformation. Transformation is thus both an idea and a goal, and praise and worship rituals – including the songs sung in worship – constitute a crucial link between the two.
The Postclassical Oral World and the Unity of Sūra 74
Authors: Archer George 
Published: June 2018

AbstractThis paper uses observations from studies of highly oral cultures to demonstrate the structural unity of Q 74, 30-31. That passage mysteriously says that over hell stands “nineteen”. This number is then followed by a strangely long aside that argues that this “nineteen” refers to angels and that “We have made their number only as a test for the disbelievers”. The reference to the nineteen has in the past been seen as unclear and the verse that follows as structurally bizarre in several ways, prompting many to argue that it is an interpolation. This article will use structural and oral rhetorical methods to suggest that this is not the case. Their content, style, and structure are all deliberate and are a response to various debates about numbers and numerology. More specifically, the passage is a correction of the Christological use of numbers by Near Eastern Christians in the Postclassical age. This article aims to show how the application of orality as a hermeneutical tool can resolve key questions regarding the coherence of the Qurʾānic text.
Was Muḥammad Amīn al-Astarabādī (d. 1036/1626-7) a Mujtahid?
Authors: Abisaab Rula Jurdi 
Published: June 2018

Abstract
The prevalent view that Muḥammad Amīn al-Astarabādī (d. 1036/1626-7) studied with a prominent uṣūlī (rationalist) jurist, namely, Shaykh Ḥasan Ṣāḥib al-Maʿālim (d. 1011/1602), the son of al-Shahīd al-Thānī (d. 965/1558), and that he was a mujtahid for most of his life before he converted to akhbārism (traditionism) in Mecca, is largely unfounded. This view surfaced during the late nineteenth century, through Muḥammad Bāqir al-Khwānsārī’s Rawḍāt al-Jannāt, and was uncritically integrated into the major bio-bibliographical accounts on al-Astarabādī’s life and scholarship afterwards. Many modern scholars in turn adopted this view, producing inadequate conclusions about the nature of his akhbārī movement. Based on a close assessment of al-Astarabādī’s extant works and his references to his teachers and places where he studied, Shiraz rather than Mecca was decisive in shaping his early traditionist stance in Shīʿa kalām (rational theology), which resonated with his traditionist positions in jurisprudence and ḥadīth. As far as one can tell through his ijāzās (scholarly licenses), he sought to transmit ḥadīth from one mujtahid, namely, Shaykh Muḥammad Ṣāḥib al-Madārik (d. 1009/1600), but did not receive training in ijtihād (rational legal inference) with him. He appears to have been well-versed in the methods used by ūṣūlī jurists to evaluate ḥadīth and derive the law, prior to that time, through his studies in Shiraz. All these findings, lead us to question the background and nature of his akhbārī thought as they were presented in much of the secondary literature, and to bring attention to a distinct set of intellectual and sociopolitical forces that shaped it.
Alamūt, Ismailism and Khwāja Qāsim Tushtarī’s Recognizing God
Authors: Virani Shafique N. 
Published: June 2018

AbstractDrawing extensively on the testimony of the Persian historians of the seventh-eighth hijri centuries (corresponding to the thirteen-fourteenth centuries of the Christian era), this article sketches a detailed picture of several personalities involved in founding the nascent Ismaili state centred at Alamūt in the fifth/eleventh century. This background sets the stage for analyzing a new manuscript source documenting Ismaili history and thought of this period, Khwāja Qāsim Tushtarī’sRecognizing God(Maʿrifat-i Khudāy taʿālā). After outlining and amending previous scholarship on this author and surveying the text’s extant manuscript and lithographic sources, the article analyzes the historical references, focusing on the figure of Sharaf al-Dīn Muḥammad, and examining the evolution of the Ismaili leadership structure. It argues for a likely date of composition between 525/1131 and 533/1139, making Tushtarī’sRecognizing Godone of the oldest Ismaili texts from Alamūt still in existence.
Al-Risāla al-Rāstbāshiyya d’Abū ʿAbd Allāh al-Ḥusayn b. Ḥamdān al-Khaṣībī, élaborateur de la religion nuṣayrite
Authors: Bar-Asher Meir 
Published: June 2018

Abstract
Al-Risāla al-Rāsbāshiyya by Abū ʿAbd Allāh al-Ḥusayn b. Ḥamdān al-Khaṣībī (d. 345/957 or 358/969) is believed by Nuṣayrīs to be the most significant doctrinal composition of the Nuṣayrī religion, and its author is regarded as perhaps the most eminent figure in the formative period of this religion.
In this work, dedicated to the Buwayhid ruler ʿIzz al-Dawla Bakhtiyār, nicknamed rāstbāsh (ruled between 357/967 and 367/978), al-Khaṣībī discusses major tenets of Nuṣayrī doctrine such as the secret of divinity; the plethora of entities emanating from it; the cyclical manifestation of the deity incarnated in human figures throughout history; the tension between the divine nature of ʿAlī, as the ultimate manifestation of God, and its human nature; the attitude towards ʿAlī’s opponents from among the companions of the Prophet MuÎammad; and the doctrine of transmigration of the soul in its variegated forms.
Although mentioned in a number of Nuṣayrī texts, al-Risāla al-Rāstbāshiyya was known to us only partially. It is only with the recent publication of this work that awareness of it has begun to grow. This article is a preliminary step towards exploring its importance for the study of early Nuṣayrī doctrine.