bluuebunny/crossref_metadata_2025_split huggingface dataset:
Photo-induced Hall effect in metals
Authors: Li D. , Ruotolo A. 
Published: March 2018

AbstractThe Hall effect in metals is too small to have practical applications. Instead, the same effect in semiconductors is the standard for magnetic field sensing. Yet, in semiconducting Hall-sensors, Joule heating severely compromises the linearity range. We here show that a Hall effect can be photo-induced in metals used for bias-free magnetic sensing. The system consists of a transparent metal that forms a Schottky contact to a semiconductor. Light reaching the interface results in the injection of charge from the space charge region. If a magnetic field is applied, a transverse, open-circuit voltage appears at the metal edges that is proportional to the field, as well as light intensity. The system shows sensitivities that are comparable to semiconducting Hall-sensors but no net current flows, therefore its performances are not affected by Joule heating.
Antagonism of Two Plant-Growth Promoting Bacillus velezensis Isolates Against Ralstonia solanacearum and Fusarium oxysporum
Authors: Cao Yu , Pi Hualiang , Chandrangsu Pete , Li Yongtao , Wang Yuqi , Zhou Han , Xiong Hanqin , Helmann John D. , Cai Yanfei 
Published: March 2018

AbstractPlant growth promoting rhizobacteria (PGPR) provide an effective and environmentally sustainable method to protect crops against pathogens. The spore-forming Bacilli are attractive PGPR due to their ease of storage and application. Here, we characterized two rhizosphere-associated Bacillus velezensis isolates (Y6 and F7) that possess strong antagonistic activity against Ralstonia solanacearum and Fusarium oxysporum under both laboratory and greenhouse conditions. We identified three lipopeptide (LP) compounds (surfactin, iturin and fengycin) as responsible for the antimicrobial activity of these two strains. We further dissected the contribution of LPs to various biological processes important for rhizosphere colonization. Although either iturin or fengycin is sufficient for antibacterial activity, cell motility and biofilm formation, only iturin plays a primary role in defense against the fungal pathogen F. oxysporum. Additionally, we found that LP production is significantly stimulated during interaction with R. solanacearum. These results demonstrate the different roles of LPs in the biology of B. velezensis and highlight the potential of these two isolates as biocontrol agents against phytopathogens.
Small RNA-seq analysis of circulating miRNAs to identify phenotypic variability in Friedreich’s ataxia patients
Authors: Seco-Cervera Marta , González-Rodríguez Dayme , Ibáñez-Cabellos José Santiago , Peiró-Chova Lorena , Pallardó Federico V , García-Giménez José Luis 
Published: March 2018

AbstractFriedreich’s ataxia (FRDA; OMIM 229300), an autosomal recessive neurodegenerative mitochondrial disease, is the most prevalent hereditary ataxia. In addition, FRDA patients have shown additional non-neurological features such as scoliosis, diabetes, and cardiac complications. Hypertrophic cardiomyopathy, which is found in two thirds of patients at the time of diagnosis, is the primary cause of death in these patients. Here, we used small RNA-seq of microRNAs (miRNAs) purified from plasma samples of FRDA patients and controls. Furthermore, we present the rationale, experimental methodology, and analytical procedures for dataset analysis. This dataset will facilitate the identification of miRNA signatures and provide new molecular explanation for pathological mechanisms occurring during the natural history of FRDA. Since miRNA levels change with disease progression and pharmacological interventions, miRNAs will contribute to the design of new therapeutic strategies and will improve clinical decisions.
Survival, gene and metabolite responses of Litoria verreauxii alpina frogs to fungal disease chytridiomycosis
Authors: Grogan Laura F. , Mulvenna Jason , Gummer Joel P. A. , Scheele Ben C. , Berger Lee , Cashins Scott D. , McFadden Michael S. , Harlow Peter , Hunter David A. , Trengove Robert D. , Skerratt Lee F. 
Published: March 2018

AbstractThe fungal skin disease chytridiomycosis has caused the devastating decline and extinction of hundreds of amphibian species globally, yet the potential for evolving resistance, and the underlying pathophysiological mechanisms remain poorly understood. We exposed 406 naïve, captive-raised alpine tree frogs (Litoria verreauxii alpina) from multiple populations (one evolutionarily naïve to chytridiomycosis) to the aetiological agent Batrachochytrium dendrobatidis in two concurrent and controlled infection experiments. We investigated (A) survival outcomes and clinical pathogen burdens between populations and clutches, and (B) individual host tissue responses to chytridiomycosis. Here we present multiple interrelated datasets associated with these exposure experiments, including animal signalment, survival and pathogen burden of 355 animals from Experiment A, and the following datasets related to 61 animals from Experiment B: animal signalment and pathogen burden; raw RNA-Seq reads from skin, liver and spleen tissues; de novo assembled transcriptomes for each tissue type; raw gene expression data; annotation data for each gene; and raw metabolite expression data from skin and liver tissues. These data provide an extensive baseline for future analyses.
Antibacterial activity and catalytic activity of biosynthesised silver nanoparticles by flavonoids from petals of Lilium casa blanca
Authors: Luo Qiushui , Su Weiwei , Li Haimin , Xiong Jianhua , Wang Wenjun , Yang Wuying , Du Juan 
Published: March 2018

Biosynthesis of silver nanoparticles (AgNPs) by flavonoids extracts from petals of Lilium casa blanca was reported. Reaction conditions such as pH, concentration of flavonoids or silver nitrite, reaction temperature and reaction time were optimised to control the formation of the AgNPs. Synthesised AgNPs were characterised by UV–Vis spectroscopy, transmission electron microscopy (TEM), dynamic light scattering (DLS), zeta potential measurement and Fourier transform infrared (FT‐IR) spectroscopy. Stability, antibacterial and catalytic activities of the synthesised AgNPs were also discussed. The optimum synthetic conditions were 10 mL 20 mM AgNO3 added to 1 mL flavonoids extracts, adjusting pH to 10, and reacted at 70°C for 1 h. The formation of AgNPs was confirmed by UV–Vis spectroscopic analysis, which showed maximum absorption peak at 404 nm. TEM analysis revealed spherical particles with size about 12.7 nm. FT‐IR spectra revealed flavonoids were present on the surface of the AgNPs. AgNPs showed highest antibacterial activity against Escherichia coli and Salmonella, and the lesser antibacterial activity of AgNPs was found against Bacillus subtilis and Staphylococcus aureus. The biosynthesised AgNPs showed good catalytic activity as well by hydroboration of p ‐nitrophenol. Catalytic reduction followed pseudo‐first‐order kinetic.
Planetesimal formation during protoplanetary disk buildup
Authors: Dra̧żkowska J. , Dullemond C. P. 
Published: March 2018

Context. Models of dust coagulation and subsequent planetesimal formation are usually computed on the backdrop of an already fully formed protoplanetary disk model. At the same time, observational studies suggest that planetesimal formation should start early, possibly even before the protoplanetary disk is fully formed.
Aims. In this paper we investigate under which conditions planetesimals already form during the disk buildup stage, in which gas and dust fall onto the disk from its parent molecular cloud.
Methods. We couple our earlier planetesimal formation model at the water snow line to a simple model of disk formation and evolution.
Results. We find that under most conditions planetesimals only form after the buildup stage, when the disk becomes less massive and less hot. However, there are parameters for which planetesimals already form during the disk buildup. This occurs when the viscosity driving the disk evolution is intermediate (αv ~ 10−3−10−2) while the turbulent mixing of the dust is reduced compared to that (αt ≲ 10−4), and with the assumption that the water vapor is vertically well-mixed with the gas. Such a αt ≪ αv scenario could be expected for layered accretion, where the gas flow is mostly driven by the active surface layers, while the midplane layers, where most of the dust resides, are quiescent.
Conclusions. In the standard picture where protoplanetary disk accretion is driven by global turbulence, we find that no planetesimals form during the disk buildup stage. Planetesimal formation during the buildup stage is only possible in scenarios in which pebbles reside in a quiescent midplane while the gas and water vapor are diffused at a higher rate.
Studying fission neutrons with 2E-2v and 2E
Authors: Al-Adili Ali , Jansson Kaj , Tarrío Diego , Hambsch Franz-Josef , Göök Alf , Oberstedt Stephan , Olivier Frégeau Marc , Gustavsson Cecilia , Lantz Mattias , Mattera Andrea , Prokofiev Alexander V. , Rakopoulos Vasileios , Solders Andreas , Vidali Marzio , Österlund Michael , Pomp Stephan 
Published: March 2018

This work aims at measuring prompt-fission neutrons at different excitation energies of the nucleus. Two independent techniques, the 2E-2v and the 2E techniques, are used to map the characteristics of the mass-dependent prompt fission neutron multiplicity, v(A), when the excitation energy is increased.
The VERDI 2E-2v spectrometer is being developed at JRC-GEEL. The Fission Fragment (FF) energies are measured using two arrays of 16 silicon (Si) detectors each. The FFs velocities are obtained by time-of-flight, measured between micro-channel plates (MCP) and Si detectors. With MCPs placed on both sides of the fission source, VERDI allows for independent timing measurements for both fragments. 252Cf(sf) was measured and the present results revealed particular features of the 2E-2v technique. Dedicated simulations were also performed using the GEF code to study important aspects of the 2E-2v technique. Our simulations show that prompt neutron emission has a non-negligible impact on the deduced fragment data and affects also the shape of v(A). Geometrical constraints lead to a total-kinetic energy-dependent detection efficiency.
The 2E technique utilizes an ionization chamber together with two liquid scintillator detectors. Two measurements have been performed, one of 252Cf(sf) and another one of thermal-neutron induced fission in 235U(n,f). Results from 252Cf(sf) are reported here.
The EFSUMB Guidelines and Recommendations for the Clinical Practice of Contrast-Enhanced Ultrasound (CEUS) in Non-Hepatic Applications: Update 2017 (Long Version)
Authors: Sidhu Paul , Cantisani Vito , Dietrich Christoph , Gilja Odd , Saftoiu Adrian , Bartels Eva , Bertolotto Michele , Calliada Fabrizio , Clevert Dirk-André , Cosgrove David , Deganello Annamaria , D’Onofrio Mirko , Drudi Francesco , Freeman Simon , Harvey Christopher , Jenssen Christian , Jung Ernst-Michael , Klauser Andrea , Lassau Nathalie , Meloni Maria , Leen Edward , Nicolau Carlos , Nolsoe Christian , Piscaglia Fabio , Prada Francesco , Prosch Helmut , Radzina Maija , Savelli Luca , Weskott Hans-Peter , Wijkstra Hessel 
Published: March 2018

AbstractThe updated version of the EFSUMB guidelines on the application of non-hepatic contrast-enhanced ultrasound (CEUS) deals with the use of microbubble ultrasound contrast outside the liver in the many established and emerging applications.
Acute Stent Migration into the Right Ventricle in a Patient with Iliac Vein Stenting
Authors: Holst Torulv , Großwendt Thorsten , Laham Majd , Roosta-Azad Mehdy , Zandi Afsaneh , Kamler Markus 
Published: March 2018

AbstractEndovascular stent placement for chronic postthrombotic iliofemoral venous obstructive lesions is an effective therapeutic option and might be complicated by stent migration. We report a case of a venous stent that was lost from the iliac vein into the right ventricle rescued by emergent open-heart surgery.
Perioperative Complications of Video-Assisted Thoracoscopic Pulmonary Procedures in Neonates and Infants
Authors: Ure Benno , Dingemann Jens , Zoeller Christoph 
Published: March 2018

AbstractVideo-assisted thoracoscopic surgery (VATS) has gained broad acceptance among pediatric surgeons. Today, VATS can be regarded as a routine approach for various conditions in neonates and infants. However, there is a lack of information concerning the complications of thoracoscopic pulmonary surgery in neonates and infants. We aimed to review the available data. A systematic review of the literature was performed using PubMed. All publications reporting on VATS for pulmonary procedures in neonates and infants up to the age of 1 year were included. Articles were reviewed in detail for occurrence of perioperative complications and their treatment. Nine case series were eligible for analysis. Entities treated included lung sequestration, congenital pulmonary airway malformation, congenital lobar emphysema, and bronchogenic cyst. Case series reported on a total number of 135 patients. Complications occurred in 14 patients (10.4%). The major complication was an accidental transection of the middle lobar bronchus that concluded in a later resection of a prior unaffected lung lobe. Other relevant complications reported were bleeding in four patients (3.0%) and persistent air leak in four cases (3.0%). Infectious complications were reported in four patients (3.0%). Additionally, iatrogenic phrenic nerve paralysis occurred in one patient. There were no deaths related to the VATS technique. In 11 cases (8.1%), conversion to thoracotomy had been necessary. General recommendations on the treatment of complications could not be derived due to small patient numbers and lack of details of the complications reported. Reports on major complications of pulmonary VATS in neonates and infants below 1 year of age are scarce. As severe complications such as accidental bronchus transection have been described, feasibility of neonatal/infant VATS cannot be unequivocally confirmed. No literature-based recommendation can be given on the treatment of complications.
Perioperatives Management des traumatisierten „Rheumatikers“ – Medikation
Authors: Biehl Christoph , Maxeiner Hagen , Rupp Markus , Heiß Christian 
Published: March 2018

ZusammenfassungDie Versorgung traumatisierter Patienten hat durch Standardisierung zu einer Verbesserung im Outcome dieser Menschen geführt. Dennoch gibt es Personengruppen, die als Hochrisiko-Patienten bei Verletzungen und deren Therapie gelten. Patienten mit Erkrankungen aus dem rheumatischen Formenkreis müssen dazu gezählt werden. Mögliche krankheitsbedingte Instabilitäten, wie die der oberen Halswirbelsäule, aber auch Frakturen bei scheinbar inadäquaten Traumata (wie Rippenfrakturen bei Drehbewegungen, Chance-Frakturen der Wirbelsäule bei Stürzen vom Stuhl) müssen bei der diagnostischen Abklärung im Rahmen des präklinischen und klinischen Schockraummanagements traumatisierter Personen berücksichtigt werden. Zusätzlich muss eine genaue Medikamentenanamnese erfolgen, um die möglichen Interaktionen und Wechselwirkungen mit der erforderlichen Therapie einschätzen zu können. Allen voran hier die immer neuen Basistherapeutika, deren Nebenwirkungsprofil und Interaktionen unter diesen Extrembedingungen nicht immer allen Therapeuten bekannt sind.
Rheumatische Erkrankungen bei Migranten
Authors: Kötter Ina 
Published: March 2018

ZusammenfassungDie Zuwanderung von Menschen aus anderen Ländern oder sogar von anderen Kontinenten stellt uns als Rheumatologen vor neue Herausforderungen. Obwohl alle entzündlich-rheumatischen Erkrankungen die hierzulande vorkommen, auch in den Heimatländern der Immigranten existieren, sind die Häufigkeiten unterschiedlich. Bei uns seltene Krankheitsbilder wie familiäres Mittelmeerfieber (FMF) oder M. Behcet sind v. a. in Nordafrika und im Mittelmeerraum oft häufiger als Spondyloarthritiden oder gar die RA. Das FMF ist zudem mit dem Auftreten einer Spondyloarthritis assoziiert, die dann häufig HLA-B27 negativ ist. Ebenso gibt es eine Assoziation mit dem M. Behcet. Auch das Rheumatische Fieber kommt v. a. in den afrikanischen Ländern noch häufig vor, während es in Europa fast ausgerottet ist. Zu beachten sind auch mögliche Differenzialdiagnosen wie rheumatische Symptome bei genetisch determinierten Anämien, oder bei Infektionen wie HIV, der Tuberkulose und Parasitosen, die allesamt in den Herkunftsländern der Migranten viel häufiger sind, als in Nordwesteuropa.
Rheumatologische Erkrankungen und Schlaf – Schlafmedizinische Aspekte der Diagnostik und Therapie – Eine literaturbasierte Übersicht
Authors: Knaack Lennart , Janicki Jaroslaw 
Published: March 2018

Zusammenfassung
Ziel des auf einer PubMed-Recherche basierenden Übersichtsartikels ist es, die Schlafphysiologie und die pathophysiologischen Zusammenhänge von rheumatologischen Erkrankungen und primären sowie sekundären Schlafstörungen darzustellen. Dabei werden die somnologische Diagnostik und Therapie als ergänzende Verfahren in die rheumatologische Behandlungsstrategie eingebunden.
Epidemiologie 70% aller Rheumapatienten berichten über einen verkürzten, oberflächlichen und wenig erholsamen Schlaf. Zudem treten bei über 20% der Erkrankungen primäre Schlafstörungen, z. B. das Schlafapnoe- und Restless Legs Syndrom, auf.
Pathogenese Primäre und sekundäre Schlafstörungen können rheumaassoziierte Symptome wie Tagesschläfrigkeit, Fatigue und Depressivität, aber auch die Schmerzintensität und Krankheitsaktivität verstärken. Umgekehrt verschlechtern Schmerzintensität und inflammatorische Marker die Schlafqualität regelhaft. Bei rheumatischen Erkrankungen können neben einer Adipositas auch krankheitsspezifische skelettale Faktoren für ein Obstruktives Schlafapnoesyndrom (OSAS) prädisponieren. Das rheumatologisch komorbide auftretende Restless Legs Syndrom (RLS) mindert die Schlafqualität durch eine sensorisch bedingte Schlafstörung, sowie schlaffragmentierende periodische Beinbewegungen.
Messverfahren Die somnologische Diagnostik umfasst introspektive Fragebögen und objektive Tests zu Reaktionsvermögen und Vigilanz. Komorbide auftretende Schlafbezogene Atmungs- und Bewegungsstörungen werden im Sinne eines apparativen und polygrafischen Screenings identifiziert. Mittels Polysomnografie im Schlaflabor erfolgt die spezifische Diagnosestellung und Therapieeinleitung sowie deren Kontrolle.
Therapie Primäre und sekundäre Schlafstörungen bei RA-Erkrankungen werden verhaltenstherapeutisch, medikamentös (Insomnie und RLS) und apparativ (OSAS) behandelt. Eine suffiziente Diagnostik und Behandlung von Schlafstörungen bei rheumatologischen Erkrankungen beinhaltet eine koordinierte und interdisziplinäre Zusammenarbeit der einzelnen medizinischen Fachgebiete.
PriLive: privacy-preserving real-time filtering for next-generation sequencing
Authors: Loka Tobias P , Tausch Simon H , Dabrowski Piotr W , Radonić Aleksandar , Nitsche Andreas , Renard Bernhard Y 
Published: March 2018

AbstractMotivationIn next-generation sequencing, re-identification of individuals and other privacy-breaching strategies can be applied even for anonymized data. This also holds true for applications in which human DNA is acquired as a by-product, e.g. for viral or metagenomic samples from a human host. Conventional data protection strategies including cryptography and post-hoc filtering are only appropriate for the final and processed sequencing data. This can result in an insufficient level of data protection and a considerable time delay in the further analysis workflow.ResultsWe present PriLive, a novel tool for the automated removal of sensitive data while the sequencing machine is running. Thereby, human sequence information can be detected and removed before being completely produced. This facilitates the compliance with strict data protection regulations. The unique characteristic to cause almost no time delay for further analyses is also a clear benefit for applications other than data protection. Especially if the sequencing data are dominated by known background signals, PriLive considerably accelerates consequent analyses by having only fractions of input data. Besides these conceptual advantages, PriLive achieves filtering results at least as accurate as conventional post-hoc filtering tools.Availability and implementationPriLive is open-source software available at https://gitlab.com/rki_bioinformatics/PriLive.Supplementary informationSupplementary data are available at Bioinformatics online.
Stakeholders’ conflicts and corporate assets: an institutional meta-complementarities approach
Authors: Landini Fabio , Pagano Ugo 
Published: March 2018

AbstractIn this paper, we argue that the relationship between shareholder conflicts and corporate assets can generate multiple equilibrium configurations that can be helpful to understand how corporate governance systems may change under different historical models of capitalism. These relationships can be modeled as ‘meta-complementarities’ existing among two different sets of institutional complementarity. The first institutional complementarity arises in realm of the conflicts among different stakeholders and generates multiple equilibria that define different systems of rights on corporate assets. The second institutional complementarity arises between corporate rights and assets. Dispersed shareholders and non-unionized workers are complementary organizational forms and generate a form of corporate governance interacting with complementary corporate assets. A similar set of institutional meta-complementarities characterizes the relation between concentrated ownership, unionized workers and corporate assets.
Transferring Patients From Methadone to Buprenorphine: The Feasibility and Evaluation of Practice Guidelines
Authors: Lintzeris Nicholas , Monds Lauren A. , Rivas Consuelo , Leung Stefanie , Dunlop Adrian , Newcombe David , Walters Carina , Galea Susanna , White Nancy , Montebello Mark , Demirkol Apo , Swanson Nicola , Ali Robert 
Published: March 2018

Introduction and Aims:
Transfer from methadone to buprenorphine is problematic for many opioid-dependent patients, with limited documented evidence or practical clinical guidance, particularly for the range of methadone doses routinely prescribed for most patients (>50 mg). This study aimed to implement and evaluate recent national Australian guidelines for transferring patients from methadone to buprenorphine.

Design and Methods:
A multisite prospective cohort study. Participants were patients who transferred from methadone to buprenorphine-naloxone at 1 of 4 specialist addiction centers in Australia and New Zealand. Clinicians were trained in the guidelines, and medical records were reviewed to examine process (eg, transfer setting, doses, and guideline adherence) and safety (precipitated withdrawal) measures. Participants completed research interviews before and after transfer—assessing changes in substance use, health outcomes, and side effects.

Results:
In all, 33 participants underwent transfer, 9 from low methadone doses (<30 mg), 9 from medium doses (30–50 mg), and 15 from high doses (>50 mg). The majority of high-dose transfers occurred in inpatient settings. There was reasonable guideline adherence, and no complications identified in the low and medium-dose transfers. Three high-dose transfers (20%) experienced precipitated withdrawal, and 7/33 participants (21%) returned to methadone within 1 week of attempted transfer.

Discussions and Conclusions:
Transfer is feasible in outpatient settings for those transferring from methadone doses below 50 mg; however, inpatient settings and specialist supervision is recommended for higher-dose transfers. The Australian clinical guidelines appear safe and feasible, although further research is required to optimize high-dose transfer procedures.