bluuebunny/crossref_metadata_2025_split huggingface dataset:
The relationship between adherence to therapy and the style of communicative interaction of the attending physician and patients undergoing coronary artery bypass graft
Authors: Pomeshkina S. A. , Solodukhin A. V. , Bezzubova A. A. , Yanitsky M. S. , Barbarash O. L. 
Published: December 2018

Aim. To study the communicative characteristics of the attending physician, assessed by the patient, and analyze their connection with adherence to the treatment of patients with coronary artery disease (CAD) undergoing coronary artery bypass graft (CABG).Material and methods. The study included 366 patients — men aged 41 to 77 years old (mean age 59,9±6,9 years) with a stable form of CAD. The patients included in the study were examined 5­7 days before the CABG and 6 months after it. The clinical condition of the patient, the presence of cardiovascular risk factors and the therapy taken before and within 6 months after were assessed. Before being discharged from the clinic, A. А. Leontiev communication card was used to determine the model of communicative interaction.Results. The higher the patient assessed the communicative competence of the doctor according to the several parameters (“benevolence”, “encouragement of initiative”, “openness”, “activity” and “flexibility”), the higher his adherence to treatment was. Patients who gave a low rating to the attending physician by the communicative parameters (“openness”, “flexibility” and “interest” in communication), had the lowest adherence to treatment.Conclusion. The adherence to treatment of CAD patients is influenced by such communicative characteristics of the attending physician as “benevolence”, “encouragement of initiative”, “openness”, “activity” and “flexibility” qualify as democratic style of communication between a doctor and a patient.
Prevention of hemorrhagic complications during operations on the thoracic aorta
Authors: Panfilov D. C. , Kozlov B. N. , Zatolokin V. V. , Ponomarenko I. V. , Khodashinsky I. A. , Shipulin V. M. 
Published: December 2018

Aim. To assess the efficiency of guideline for the prevention of hemorrhagic complications in the early postoperative period.Material and methods. In the period from 2008 to 2017, 166 patients with pathology of the thoracic aorta were operated. The patients were divided into 2 comparable groups: group 1 — patients with reconstructed aortic arch of the type “Hemiarch” (group “hemiarch”, n=90), group 2 — patients with fully reconstructed aortic arch (group “arch”, n=76). All operations were performed with artificial blood circulation, circulatory arrest with moderate hypothermia (25­28° C) and unilateral antegrade cerebral perfusion through the brachiocephalic trunk.Results. The reconstructions of the thoracic aorta in patients of the “hemiarch” group were accompanied by significantly less period of artificial blood circulation (p=0,027), cardiac arrest period (p=0,012), duration of circulatory arrest (p=0,019), and duration of antegrade brain perfusion (p=0,021). The volume of discharge through the drainage was 350 [192;506] ml and 400 [250;723] ml in the “hemiarch” and “arch” groups, respectively (p=0,29). Patients of the “arch” group more often required transfusion of packed red cells (p=0,003), fresh frozen plasma (p=0,0006), platelet concentrate (p=0,002) in comparison with patients of the “hemiarch” group. At the same time, the frequency of bleeding requiring reoperation was comparable in both groups (5,6% versus 5,3%, p=0,969). The 30­day mortality also had no statistically significant differences in patients of the “hemiarch” and “arch” groups (3,3% versus 9,2%, p=0,119).Conclusion. The frequency of hemorrhagic complications requiring reoperation in patients with a fully or partially reconstructed aortic arch does not have significant differences when using the guideline for preventing of hemorrhagic complications, which makes it possible to provide acceptable frequency of bleeding episodes and reoperations in the early postoperative period.
Comparative assessment of bone mineral density in recipients with preserved function and calcium degeneration of heart valve bioprotheses
Authors: Rutkovskaya N. V. , Stasev A. N. , Kondyukova N. V. , Kuzmina O. K. , Fanaskov V. B. , Barbarash L. P. 
Published: December 2018

Aim.To study a bone mineral density (BMD) in recipients with calcium degeneration and preserved morphofunctional state of heart valve bioprotheses (BP).Material and methods.The experimental groups included the patients with structural dysfunctions of BP associated with the calcification of the xenomaterial, confirmed by light and electron microscopy data (group I, n=22) and the patients with normal functional state of the implanted valves according to the results of echocardiographic tests (group II, n=48). BMD was assessed by dual energy absorptiometry in the absolute count of mineralized bone and indicators of T­test.Results. When interpreting the T­test of a femoral neck the severity of osteopenic syndrome prevailed in patients with calcium degeneration of BP (­1,83 [­2,66; ­1,25] in group I vs ­1,47 [­2,51; ­0,86] in group II, р=0,055). At that the mean values of this indicator in patients with the development of calcium­associated BP dysfunctions in the first four years after a surgical correction of the defects reached the diagnostic criteria of the osteoporosis (­2,73 [­3,40; ­2,09] vs ­1,67 [­2,92; ­0,42], р>0,05). According to the result of absorptiometry of the lumbar spine the worst Т­score indicators were also recorded in recipients with the calcification of BP within the first four years of follow­up (­1,75 [­1,83; ­1,43] vs ­0,81 [­0,96; ­0,66] in patients without the signs of calcification, р=0,021). The state of BMD reflects the physiological and pathological processes of calcium redistribution in organism. The existence of the pathogenetic parallels between the activity of bone resorption processes and calcification of the elements of cardiovascular system allows to consider the osteopenia and pathological mineralization of the soft tissues within the framework of a single continuum. The results of the presented work in their turn testify to the determining significance of the severity of osteopenic syndrome manifestations in the development of the “early” calcium degeneration of BP.Conclusion.Extension of the concepts of the mechanisms and processes which form the pathogenetic basis of mineralization will allow to determine the effective strategies for managing the risk of calcium­associated BP dysfunctions.
GEL PİSİ PİSİ: BİLGE KARASU’NUN KEDİLERİ
Authors: KOÇ Yasemin 
Published: December 2018

Çağdaş Türk
edebiyatının özgün isimlerinden Bilge Karasu’nun metinlerinde dile ve kurguya
yön veren; aynı zamanda Karasu yazınının “sorunlar alanı”nda kendisine yer
edinen en belirgin meselelerden birisi de hayvan sorusudur. Metinlerde
karşımıza çıkan pek çok hayvanın arasında kediler ayrı bir yere sahiptir.
Karasu’nun kişisel yaşamından yazın yaşamına kadar uzanan bir çizgide kediler
belirgin bir öneme ve işleve sahip olmuşlardır. Bu makalede yazarın hem düşün
dünyasına hem de yazınına kedilerin hangi yönlerden, nasıl etki ettiği açıklanmaya çalışılmıştır. Bunu yaparken de
yazarın mektupları, denemeleri gibi verilerden faydalanılmış, metinmerkezli bir
yaklaşımla da kurgusal metinleri analiz edilmiştir.
Interlay versus underlay type 1 tympanoplasty: a comparative study of the techniques in 100 cases
Authors: Sharma Nitin , Sharma Pritosh , Goyal V. P. , Sharma Kumar Gaurav 
Published: December 2018

<p class="abstract"><strong>Background:</strong> Type 1 tympanoplasty is a surgical technique used to restore the integrity of tympanic membrane as well as to improve hearing level in patients with large central perforations (inactive mucosal chronic otitis media).</p><p class="abstract"><strong>Methods:</strong> This is a randomized prospective study of 12 month duration from January 2017 to December 2017 in 100 patients of chronic otitis media inactive mucosal type with large central perforation admitted in the E.N.T department at Geetanjali Medical College and Hospital, Udaipur. </p><p class="abstract"><strong>Results:</strong> The graft uptake rate in the present study was found to be 96% and 90% respectively in interlay and underlay techniques. Post operatively after 12 weeks mean air bone gap was maximum reduced in Interlay tympanoplasty.</p><p class="abstract"><strong>Conclusions:</strong> The present study showed that Interlay technique had a better graft take rate as well as hearing improvement in large central perforation of chronic otitis media than the underlay technique.</p>
Pemberdayaan Pelaku Ekonomi Sektor Melalui Peningkatan Pemahaman Konsep Wisata Syariah
Authors: Ansharullah Ansharullah , Natasha Harum , Indra Adam Malik 
Published: December 2018

Tujuan pengabdian ini adalah meningkatkan pemahaman konsep wisata syariah bagi pelaku ekonomi sektor pariwisata, meningkatkan pelayanan di sektor pariwisata dan meningkatkan pendapatan bagi para pelaku ekonomi di sektor pariwisata di kabupaten Rokan Hulu provinsi Riau. Adapun subjek dari pengabdian ini adalah para pelaku ekonomi sektor pariwisata yang ada di mesjid Agung Islamic Centre kabupaten Rokan Hulu. Sedangkan Objeknya adalah peningkatan pemahaman tentang pariwisata syariah. Metode pemberdayaan adalah Model Pemberdayaan PLA (Participatory Learning and Action), atau Proses Belajar dan Praktek Secara Partisipatif dengan mengadakan Uji Kompetensi Awal dan akhir. Bedasarkan hasil pengabdian dapat disimpulkan bahwa Pengetahuan dan pemahaman pelaku ekonomi sektor pariwisata di Mesjid Agung Islamic centre kabupaten Rokan Hulu tentang konsep wisata syariah menjadi meningkat.

Kata Kunci : Pemberdayan, Pemahaman, Pelaku ekonomi, pariwisata syariah
Las representaciones sociales del conflicto: una mirada desde la escuela
Authors: Montoya Páez Víctor Hugo , Roberto Cardona Andrés 
Published: December 2018

El artículo muestra la síntesis de un trabajo investigativo, cuyo objetivo es la comprensión sobre las representaciones sociales del conflicto de los docentes, directivos docentes y estudiantes de la media académica, en las instituciones educativas Joaquín Vallejo Arbeláez y El Salvador de la ciudad de Medellín. Así mismo identificar su procedencia dentro de la escuela como contexto educativo.Se caracterizó el concepto de conflicto y sus elementos constitutivos (causas, proceso, protagonistas y contexto). Se describen las posibilidades que son ofrecidas en la escuela para su tratamiento y la procedencia de las representaciones sociales del conflicto, con el propósito de identificar las fuentes que impactan la comunidad de las instituciones educativas en mención. La metodología utilizada en este estudio es de carácter cualitativa-hermenéutica, no obstante, para el diagnóstico de la problemática en la población se recurrió a datos cuantitativos, para tener claridad sobre el estado del objeto de investigación. Se utilizaron como técnicas de indagación la entrevista semiestructurada, el fotolenguaje y el cuestionario; cabe aclarar que este último hizo acopio de preguntas cerradas y abiertas (mixto), lo cual permitió a los encuestados ampliar, según su criterio, la respuesta en los interrogantes planteados. A la técnica del fotolenguaje se le aplicó un análisis paradigmático y, los dos restantes, se trabajaron mediante un análisis autorreferencial. Este estudio tomó la teoría de la representación social y sus dimensiones (la información, el campo de la representación y la actitud), como forma de conocimiento, pues las construcciones conceptuales realizadas por las comunidades se derivan en estructuras de comprensión de la realidad, así las representaciones sociales permitieron realizar un diagnóstico de las circunstancias especiales de un contexto determinado, puesto que para su elaboración un sujeto comparte sus representaciones individuales para luego asimilar las de la colectividad.
Discovery of Potent Inhibitors for the Inhibition of Dengue Envelope Protein: An In Silico Approach
Authors: Aarthy Murali , Singh Sanjeev Kumar 
Published: December 2018

Background:
Dengue fever, a major public health problem in the tropical and sub-tropical
countries caused by the infection of Dengue virus transmitted by the anthropod vectors. The dengue virus
infection is represented as the “Neglected Tropical Diseases” by the world health organization. The
structural protein E binds to the receptor on the host cell surface during infection and the binding directs
to the endocytic pathway. The conformational change of the envelope protein helps to infuse the viral
lipid membrane and delivers the viral genome into the cytosol. No specific treatments are available till
date and development of the vaccine for the DENV is challenging due to the immunization and longlasting
protection against all four serotypes. Hence, identification of potent inhibitors would overlay the
therapeutics against the mediated diseases.

Objective:
Our study focuses on developing the novel potent inhibitors to inhibit the viral attachment
and membrane fusion of the Dengue virus Envelope protein.

Methods:
The crystal structure of Dengue Envelope protein has been retrieved from the protein data
bank and optimized through Schrödinger. The structure-based virtual screening based on the cocrystallised
ligand has been carried out with the small molecule libraries, and based on the docking
score, interaction and energy value best complexes were selected. The selected complexes were further
taken forward for the conformational stability analysis through Molecular dynamics simulation.

Results:
Around 55 molecules from the three databases were identified as potential binders to the envelope
protein and the docking studies revealed that the top compounds possess strong interaction with the
good energies. The Molecular electrostatic surface potential of the top five compounds states that the
interactions were observed mostly in the electropositive region. Finally, the best 5 compounds carried
further for molecular dynamics simulations exposed that they were highly stable and no loss of interactions
was observed between those complexes.

Conclusion:
Hence, from the results, it is evident that the compounds DB00179, Quercetin, Silymarin,
Dapagliflozlin and Fisetin could be novel and potent candidates to inhibit the DENV envelope protein.
Cost-effectiveness Analysis of Routine Screening Using Massively Parallel Sequencing for Maturity-Onset Diabetes of the Young in a Pediatric Diabetes Cohort: Reduced Health System Costs and Improved Patient Quality of Life
Authors: Johnson Stephanie R. , Carter Hannah E. , Leo Paul , Hollingworth Samantha A. , Davis Elizabeth A. , Jones Timothy W. , Conwell Louise S. , Harris Mark , Brown Matthew A. , Graves Nicholas , Duncan Emma L. 
Published: December 2018

OBJECTIVE
Maturity-onset diabetes of the young (MODY) is an autosomal dominant form of diabetes, with multiple causative genes. Some MODY subtypes can be treated with sulfonylureas instead of insulin, improving glycemic control, complication rates, quality of life (QoL), and costs. Using massively parallel sequencing (MPS), we recently determined the prevalence of pathogenic/likely pathogenic MODY variants in an Australian pediatric diabetes cohort. Here, these data are used to estimate cost-effectiveness of using MPS for MODY in all pediatric diabetes cases compared with standard practice (sequencing limited to individuals with specific clinical features).

RESEARCH DESIGN AND METHODS
A Markov decision model was developed to estimate incremental costs and quality-adjusted life-years (QALYs) of MPS screening, modeled over 30 years. We used our observed prevalence of 2.14% compared with 0.7% for standard practice, based on published data. The probabilities and utility weightings of long-term diabetes complications were based on HbA1c and estimated from published data. A series of one-way sensitivity analyses were performed using the net monetary benefit framework.

RESULTS
Routine MPS screening for MODY was more effective and less costly than standard care screening, with 26 QALYs gained and 1,016,000 AUD (782,000 USD) saved per 1,000 patients. Cost of screening was fully offset within 10 years. Routine MPS screening remained dominant until MODY prevalence fell to &lt;1.1%.

CONCLUSIONS
Routine MPS screening for MODY in the pediatric population with diabetes could reduce health system costs and improve patient QoL. Our results make a compelling argument for routine genetic screening in all children with presumed type 1 diabetes mellitus.
Insulin Clearance After Oral and Intravenous Glucose Following Gastric Bypass and Gastric Banding Weight Loss
Authors: Shah Ankit , Holter Marlena M. , Rimawi Fatima , Mark Victoria , Dutia Roxanne , McGinty James , Levin Bruce , Laferrère Blandine 
Published: December 2018

OBJECTIVE
Hepatic insulin clearance is a significant regulator of glucose homestasis. We hypothesized that the improvement in insulin clearance rates (ICRs) under fasting conditions and in response to oral and intravenous (IV) glucose would improve similarly after Roux-en-Y gastric bypass (RYGB) and adjustable gastric banding (AGB) as a function of weight loss; the difference in ICR after oral and IV glucose stimulation will be enhanced after RYGB compared with AGB, an effect mediated by glucagon-like peptide 1 (GLP-1).

RESEARCH DESIGN AND METHODS
In study 1, the ICR was calculated under fasting condition (F-ICR), after oral glucose (O-ICR), and after an isoglycemic IV glucose clamp (IV-ICR) in individuals from an established cohort with type 2 diabetes mellitus (T2DM) before, after 10% matched weight loss, and 1 year after either RYGB (n = 22) or AGB (n = 12). In study 2, O-ICR was studied in a separate cohort of individuals with T2DM (n = 22), before and 3 months after RYGB, with and without exendin(9-39) infusion.

RESULTS
In study 1, age, BMI, T2DM duration and control, and ICR did not differ between RYGB and AGB preintervention. Weight loss at 1 year was two times greater after RYGB than after AGB (31.6 ± 5.9% vs. 16.6 ± 9.8%; P &lt; 0.05). RYGB and AGB both significantly increased F-ICR, O-ICR, and IV-ICR at 1 year. ICR was inversely associated with insulinemia. The difference between IV-ICR and O-ICR was significantly greater after RYGB versus AGB. GLP-1 antagonism with exendin(9-39) led to an increase in O-ICR in subjects post-RYGB.

CONCLUSIONS
Weight loss increased ICR, an effect more pronounced after RYGB compared with AGB. Our data support a potential role for endogenous GLP-1 in the control of postprandial ICR after RYGB.
Participating in Mental, Social, and Physical Leisure Activities and Having a Rich Social Network Reduce the Incidence of Diabetes-Related Dementia in a Cohort of Swedish Older Adults
Authors: Marseglia Anna , Wang Hui-Xin , Rizzuto Debora , Fratiglioni Laura , Xu Weili 
Published: December 2018

OBJECTIVEThe effect of a healthy lifestyle on diabetes-related dementia remains unknown. We examined whether an active lifestyle and rich social network may counteract the increased risk of dementia in people with diabetes.RESEARCH DESIGN AND METHODSDementia-free older adults from the Swedish National Study on Aging and Care in Kungsholmen (SNAC-K) (n = 2,650) were followed up for 10 years. Diabetes was ascertained on the basis of medical history, medication use, medical records, or glycated hemoglobin (HbA1c) ≥6.5% and prediabetes as HbA1c between 5.7 and 6.5%. Dementia was diagnosed by specialists following standard criteria. An active lifestyle was defined as a moderate to high (vs. low) level of engagement in leisure activities or a rich social network (having moderate to rich [vs. poor] social connections and support). Hazard ratios (HRs) of dementia risk were derived from Cox regression models.RESULTSThere were 246 incident dementia cases during follow-up. Those with diabetes (n = 243), but not those with prediabetes (n = 921), had greater risk of dementia (adjusted HR 2.0 [95% CI 1.4–2.9]) than diabetes-free participants. Participants with diabetes but low level of engagement in leisure activities (HR 4.2 [95% CI 2.2–8.2]) or a poor social network (HR 3.4 [95% CI 1.9–6.1]) had greater dementia risk than diabetes-free participants with moderate to high levels of leisure activity engagement or a moderate to rich social network. In participants with diabetes, an active lifestyle (high level of engagement in leisure activities or a rich social network) was associated with less of a raised risk (HR 1.9 [95% CI 1.1–3.4]).CONCLUSIONSAn active and socially integrated lifestyle may significantly counteract the detrimental effect of diabetes on dementia risk.
Vertical and Longitudinal Characteristics of a Bicycle Tire
Authors: Maier Oliver , Hillenbrand Stefan , Wrede Jürgen , Freund Andreas , Gauterin Frank 
Published: December 2018

ABSTRACT
Electric bicycles have undergone a real boom in recent years and play an important role in the area of sustainable mobility. In addition to assisting the rider while accelerating the bicycle, the available electrical energy also offers the possibility to deploy safety systems to reduce the risk of accidents. For instance, active safety systems could help to avoid two major critical braking situations for single-track vehicles: front wheel lockup and nose-over (i.e., falling over the handlebars).
An essential prerequisite for the development of such systems is a thorough understanding of tire effects on bicycle dynamics. To date, there are only very few scientific studies concerning bicycle tire characteristics. Thus, test runs on an inner drum tire test bench have been performed to measure vertical and longitudinal characteristics of a typical trekking bike tire.
This article presents the main findings such as vertical stiffness and contact patch geometry depending on wheel load and inflation pressure as well as characteristic curves of the longitudinal force depending on slip with variation in road condition, wheel load, speed, and inflation pressure. Based on these valuable insights, further improvements are proposed, and an outlook on the next research steps is given.
A Calculational Aero-Acoustic Study of Spokes of an Isolated Nonpneumatic Tire
Authors: Huang Mufeng , Zhou Haichao , Li Kaiqiang , Wang Guolin 
Published: December 2018

ABSTRACT
With the progress of noise control of engines and the rise of new energy vehicles, the severity of tire noise has been increasingly highlighted. Recently, the nonpneumatic tire (NPT) has drawn attention because of its novel structure design that surpasses traditional tires in anti-explosion, maintenance-free, and low rolling resistance characteristics. However, with an open-side structure and violent air impact at the flexible spokes, an NPT emits greater aerodynamic noise than a pneumatic tire during high-speed rolling, which results in an adverse effect on the riding comfort of vehicles.
The arrangement pattern of flexible spokes in an NPT plays an important role in the generation of aerodynamic noise. In this study, the aerodynamic flow around NPTs, which were in contact with the ground, rolled at a speed of 80 km/h, and had different arrangement patterns of spokes, was investigated using the Reynolds-Averaged Navier-Stokes method and Large-Eddy Simulation. Then, the far-field aerodynamic noise of different NPTs were calculated using Ffowcs Williams-Hawkings equations in the acoustic model of ANSYS-Fluent. The influence of spoke arrangements on the flow pattern and aerodynamic noise was analyzed. Based on the results, we propose an optimized design of spokes that can enhance the aero-acoustic performance of NPTs.