bluuebunny/crossref_metadata_2025_split huggingface dataset:
Traditional Remedies for Wound Healing: A Review
Authors: SHAIKH Shakila Shabbeer , Ukande Manisha D. , Murthy Krishna , Shete Rajkumar V , Solunke R.S. 
Published: September 2019

Wounds are a natural part of everyday life that can be successfully treated with the knowledge of Ayurveda. Ayurveda is the study of science that is based on herbal remedies. A wound must progress through vrana shodhana (wound purification) and vrana roopana (wound healing) and pass through the four stages of wound healing; dushta vrana (septic wound), shudh vrana (clean wound), roohyamana vrana (healing wound), and roodha vrana (healed wound). Through this, Ayurveda has revealed knowledge for treating conditions that can’t be treating by the modern medicine. Ghee-based herbal formulations claimed to promote wound healing in traditional practices. This article aims to provide probable scientific explanations for using medicated ghrita (ghee) as wound healing formulation in Ayurvedic system of medicine and its clinical importance.
Keywords: Ayurveda, Wound, Ghrita, Wound healing.
Cytotoxic Anti-Cancer Activity of Certain Thermotropic Liquid Crystalline Poly (Ester-Amides) Containing 2, 6-Bis (Benzylidene)Cyclohexanone Moiety in the Main Chain
Authors: Kalappa Kavitha Erra , Ramalakshmi N. 
Published: September 2019

Five thermotropic liquid crystalline poly(ester-amides) were synthesized by polycondensation method. The poly(ester-amides) were synthesized from varying dicarboxylic acids with a common diamine namely 4,4'-diaminobenzene and a common diol namely 2,6-bis(4-hydroxybenzylidene))cyclohexanone. For qualitative characterization, viscosity measurements and solubility data were used for these synthesized poly(ester-amides). The spectroscopic techniques such as FT-IR, 1H NMR, 13C NMR were performed to investigate the microstructural features of these synthesized poly(ester-amides). The thermal phase transition behavior of these poly(ester-amides) were studied by Differential Scanning Calorimetry (DSC) and Hot-stage Optical Polarized Microscopy (HOPM). The degree of crystallinity was assessed by X-ray diffraction (XRD) patterns. Scanning Electron Microscopic (SEM) technique was used to illustrate the morphology of these poly(ester-amides). The copolymer synthesized was subjected into in vitro anti-cancer activity studies against human breast cancer (MCF-7) cell line.
Keywords: Bisbenzylidenecyclohexanone; poly(ester-amides); polycondensation; thermotropic liquid crystalline properties; cytotoxicity, anticancer.
Review on Teneligliptin: A novel antihyperglycemic agent
Authors: Gorde V. D. , Rachh Punit R. 
Published: September 2019

Diabetes mellitus relates a metabolic disorder of collective aetiology which is characterized by chronic hyperglycaemia caused due to disturbances of carbohydrate, lipid and protein metabolism due to impaired β cell function of pancreas or insulin resistance or both. Dipeptidyl peptidase-4 (DPP-4) inhibitors have recently emerged as a new class of antidiabetic that show favorable results in improving glycemic control with a minimal risk of hypoglycemia and weight gain. Teneligliptin is a recently developed oral dipeptidyl peptidase 4 inhibitor indicated for the management of type 2 diabetes mellitus. Teneligliptin, characterized by a "J-shaped" structure formed by five consecutive rings which give unique binding characteristics, reflect in higher potency than other dipeptidyl peptidase 4 inhibitor. Teneligliptin is a novel antihyperglycemic agent with a preferable profile in terms of long-term efficacy and safety in patients with type 2 diabetes.
Keywords: Diabetes Mellitus, Dipeptidyl Peptidase 4 Inhibitor, Teneligliptin, Hypoglycemia,
Hepatoprotective Effect of Tagetes Erecta L. Extract on Carbon Tetrachloride Induced Hepatotoxicity in Rats
Authors: Vidyadhar Kamshetti Manoj , Sharma Hemant Kumar 
Published: September 2019

Tagetes erecta L. is a widespread garden plant that is commonly known as the marigold, and it is widely used as a medicinal herb for its anti-inflammatory, analgesic, and anti-edematous properties, which are important for phytotherapeutic, dermatological and cosmetic applications. In this study, the protective effects of water extract of Tagetes erecta L. against liver damage were evaluated in carbon tetrachloride (CCl4)-induced chronic hepatotoxicity in rats. The results showed that the treatment of extract significantly lowered the CCl4-induced serum levels of hepatic enzyme markers (GOT, GPT, ALP, and total bilirubin Liver histopathology showed that extract reduced the incidence of liver lesions including hepatic cells cloudy swelling, lymphocytes infiltration, hepatic necrosis, and fibrous connective tissue proliferation induced by CCl4 in rats. Therefore, the results of this study suggest that Tagetes erecta L. Extract could protect liver against the CCl4-induced oxidative damage in rats, and this hepatoprotective effect might be contributed to its modulation on detoxification enzymes and its antioxidant and free radical scavenger effects.
Keywords: Tagetes erecta L., Carbon Tetrachloride, Liver Damage, Hepato-protection
Antitumor efficacy of Folic Acid conjugated Polymeric Nanoparticles of SN-38 after oral delivery
Authors: Shilpi Prasad , Dangi J.S 
Published: September 2019

The objective of the present research was to develop folic acid conjugated polymeric nanoparticles (FCsPNP) and to investigate its therapeutic effectiveness in xenograft Colon tumor models after oral delivery. Chitosan coated PLGA nanoparticles (CsPNP) were prepared by polyelectrolyte complexation method and it was further conjugated with Folic acid. Optimized formulation was investigated for particle size, zeta potential, polydispersity index (PdI), % entrapment drug loading and in vitro release. The morphology was observed by SEM and TEM images. Tumor regression studies were conducted on Balb/c mice implanted with Colo-26 cells. FCsPNP were successfully prepared and optimized. In vitro parameters viz. Particle size, Zeta potential, PdI were found to be optimum. The in vitro % release is directly correlated with the nature of polymers and folate conjugation. In vivo tumor regression studies found the formulations to be less toxic than Irinotecan hydrochloride (IHCl). CsPNP and FCsPNP were successfully prepared and evaluated for antitumor efficacy after oral delivery. FCsPNP were more effective in the colon tumor treatment and found to be less toxic than IHCl thus making it a potential drug delivery candidate for future anticancer therapy.
Keywords: Nanoparticles, Xenograft colon tumor, Chitosan, Irinotecan hydrochloride
Qualitative and Quantitative Evaluation of Flavonoids from Corchorus olitorius L.
Authors: Dhayal Kalpna , Kumar Dileep 
Published: September 2019

Corchorus olitorius is fibre yielding plant with nutritive value so human used its various parts in their food. Flavonoids are secondary metabolites of plants and exist with variable phenolic structures.In the present study carried out the qualitative and quantitative analysis of flavonoids by using chromatographic and spectral studies.Total amount of flavonoids were found in Corchorus olitorius ( 0.55 mg/gdw in stem and 0.30 mg/gdw in fruit). Thirty three compound were found in GC-MS analysis, Ethyl Oleate found to be maximum from fruits of Corchorus olitorius.
Keywords: GC-MS,flavonoids , Corchorus olitorius.
Challenges Faced During eCTD and CTD Filling Procedures for USFDA and Canada
Authors: Ahammad Nisar , Reddy Nagarjuna , Nagabhushanam M.V. , Ramakrishna Brahmaiah 
Published: September 2019

Electronic Common Technical Document (eCTD) is a topic of increasing interest in the pharmaceutical Industry as it become compulsory for filing procedures. The Common Technical Document (CTD) is a set of specification for application dossier, for the registration of Medicines and designed to be used across Europe, Japan and the United States.Quality, Safety and Efficacy information is assembled in a common format through CTD .The CTD is maintained by the International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use (ICH). Electronic common technical documentis an interface used by applicants of marketing authorisation for medical products to submit regulatory affairs document to the agency concerned. The purpose of this article is to present a concise overview of challenges faced during eCTD & CTD submissions in United States and Canada. A regulatory process, by which a person/organization/ sponsor/innovator gets authorization to launch a drug in the market, is known as registration process. The registration process will be done by submitting technical information to the authority
Keywords: electronic common technical document (ECTD)/ (CTD), International conference on hormonisation (ICH), Drug registration process.
Formulation Development and Evaluation of Sustain Release Gastroretentive Floating Tablets of Prochlorperazine Dimaleate
Authors: Patle Bharti , Jain Vivek , Shende Shradha , Jain Prabhat Kumar 
Published: September 2019

Floating drug delivery systems are the gastroretentive forms that precisely control the release rate of target drug to a specific site which facilitate an enormous impact on health care. The purpose of this research was to develop a novel gastro retentive drug delivery system based on direct compression method for sustained delivery of active agent to improve the bioavailability, reduce the number of doses and to increase patient compliance. Gastro retentive floating tablets of Prochlorperazine dimaleate (PCZ) were prepared by direct compression method using altered concentrations of HPMC K4, HPMC K15 and PVP K30 as polymers. The prepared tablets of PCZ were evaluated for hardness, thickness, friability, weight variation, drug content uniformity, buoyancy lag time, total floating time, in-vitro dissolution study, etc. All the compositions were resulted in adequate Pharmacopoeial limits. Compatibility studies was execution during FTIR shown that there was absence of probable chemical interaction between pure drug and excipients. The varying concentration of gas generating agent and polymers was found to affect on in-vitro drug release and floating lag time. In vitro drug release of floating gastro retentive tablet of PCZ shown that the formulation F9 was found to be the best formulation as it releases 98.89% in a controlled manner for an extended period of time (up to 12 hrs). The release data was fitted to various mathematical models such as Higuchi, Korsmeyer-Peppas, First order and Zero order to evaluate the kinetics and mechanism of the drug release. The optimized formulation (F9) showed no significant change in physical appearance, drug content, floating lag time, in vitro dissolution studies after 75%±5% RH at 40±20C relative humidity for 6 months. Prepared floating tablets of PCZ may prove to be a potential candidate for safe and effective controlled drug delivery over an extended period of time for gastro retentive drug delivery system.
Keywords: Prochlorperazine dimaleate, Floating tablet, Gastro retentive, Total floating time.
Formulation and Evaluation of Glucosamine Sulphate Potassuim Chloride 1500 Mg and Methyl Sulphonyl Methene 200 Mg Film Coated Tablet
Authors: Abbas Jameel , Ansari Yaasir Ahmed , Malik Tauheed Ahmad , Sayed Isar Ahmad , Sayyed Mukhim , Azharuddin Mohd. 
Published: September 2019

Methyl Sulphonyl methane (MSM) is an organ sulfur compound with the formula (CH3)2SO2. Glucosamine is naturally hygroscopic is nature when exposed to air and moisture and degradable whether in the form of tablet or raw material. To overcome this problem Glucosamine needs to bond with suitable stabilizer. Glucosamine Sulphate in the form of Salt i.e. Sodium chloride and potassium chloride are stable. The normal dose of Glucosamine is 500-1500 mg TID. It is very difficult to compress the tablet at the label claim 1500 mg because some additives are also required in the formulation and the average weight is 1800 mg. As per the pre formulation studies it is concluded that tablet average weight less than 70 mg are very difficult to compress and more than 1500 mg are difficult to swallow in adult patient. Glucosamine stimulates the formation or manufacture of collagen, the protein portion of the fibrous substance that holds joints together and provides a shock-absorbing cushion, as a person ages, the cartilage that cushions the joints often loses its ability to support healthy cellular growth. This condition, called osteoarthritis, often leads to rough bones that rub together and cause distress with every twist or bend. In this condition patient regularly required the Glucosamine tablet in 1500 mg three times a day. But it’s very difficult to compress the tablet at huge weight because D tooling compression machine have maximum limit is 1500 mg. For such critical formulation weight cam is adjusted in lower direction to increase the weight and feeding of granules in feed frame through force feeder resolve the dissolution problem. This tablet is prepared by wet granulation method by using Non Aqueous binding showed good results physical evaluation parameters and chemical parameters such as Assay, and Dissolution values. The granules are lubricated using suitable lubricants / Glidant / Antiadhrants were good in their flow properties. Assay and dissolution studies were conducted by the HPLC method.
Gastroretentive Mucoadhesive Microsphere for the Management of Gastric Infection
Authors: Mishra Sri Prakash , Nayak Amit , Mishra Dinesh Kumar , Kumar Abhay 
Published: September 2019

Gastric infections are mostly triggered by Helicobacter pylori (H. pylori), a fungus that colonizes the stomach mucosa of more than 50% of the inhabitants of the world. Chronic H. Pylori diseasewas associated with stomach diseases such as peptic ulcer, chronic gastritis and stomach adenoc arcinoma. Current therapy for eradication relies on antibiotic-based therapies that are ineffective in about 20% of patients. Traditional method constraints optimize the creation of new techniques for fast, consistent and cost-effective H diagnosis. Infection with pylori. Wide-ranging study has been carried out over the previous few centuries to create a type of gastro-retentive dosage (GRDF). This sort of dosage form can advance the delivery and efficiency of stomach-active medicines because the GRDF enables the medication to remain in the stomach for a sufficient time period. Various methods were used to develop effective GRDFs such as high-density systems, low-density systems, swelling and expansion systems, hydrodynamically balanced systems, superporous hydrogels,. However, there are both merits and demerits in these kinds of schemes. Intra-individual and inter-individual dissimilarities are obstacles to the growth of effective GRDFs in gastric physiology. Examples of these individual differences include gastric pH and gastric motility that have a notable effect on the moment of stomach retention and delivery of drugs. Some of these obstacles can be overcome by developing a novel mucoadhesive microsphere. The mucoadhesive microsphere is characterized by close contact of the MDF with the mucosal layer, thereby increasing the localized absorption of the drug. H2Receptor antagonists (H2RAs) have become first-line therapy for acid related peptic disease and GRDF especially designed for H2RAs and drugs against H. pylori, including specific targeting systems and leading to a marked development in the quality of life for a large number of patients. In this relationship, new formulations with improved absorption, improved bioavailability and improved acid-suppressing regimens are welcome
Keywords: H. pylori, gastro-retentive dosage, mucoadhesive microsphere
A STUDY ON PHYTOCHEMICALS SCREENING OF PHYSICO-CHEMICAL PARAMETERS AND FLUORESCENCE ANALYSIS OF INSULIN MEDICINAL PLANTS Costus spicatus- JACQ.
Authors: Senthilkumar S , Azhagu Madhavan S , Andrews S , Ganesan S 
Published: September 2019

Objective: To evaluate the diagnostic pharmacognostical characters of Costus spicatus flower extract along with their Phytochemical screening of physico-chemical parameters, fluorescence and Vitamins analysis.
Methods: The pharmacognostical characters were determined in terms of Costus spicatus flower extract constant, fluorescence analysis and Preliminary phytochemical investigation.
Result: Plant products are believed to more preferable due to less toxicity, economic and better patient compliance. Vitamins are organic substances that are essential in minute amounts designed for growth and activity of the body. The term also means that vitamins can be destroyed and become unable to perform their functions inour bodies. The phytochemical report of the plant exposed the presence of alkaloids, carbohydrates, flavonoids, proteins, amino acids, phenols, tannins, glycosides and steroids as organic phytoconstituents. Every constituent plays an important role and deficiency of any one constituent may lead to abnormal developments in the body. Plants are rich source of all the elements essential for human being. Qualitative analysis of various inorganic elements revealed the presence of Calcium, Magnesium, Potassium, Iron, sulphates and phosphates.
Conclusion: The present study of good source of Costus spicatus may be useful for human health associated emerging diseases such as diabetes, hypertension and cancer.
Keywords: Diabetes mellitus, vitamins, Costus spicatus, physico-chemical parameters, fluorescence analysis
Summary and application analysis of clinical herniorrhaphy mesh materials
Authors: Liu Yan , Zuo Yanbo , Jiao Zhengwei , Jin Xiaoshi 
Published: September 2019

It is widely believed in the medical community that the pathological and anatomical basis for the occurrence of external abdominal hernia is the fascia defect, and how to correctly deal with this kind of fascia defect is the key point in the treatment of external abdominal hernia. Theodore Billorth famously said that if we could artificially create dense and tough tissues like fascia and tendons, the secret to the complete healing of hernia would be solved. These similar theories largely guide the research and practice in the treatment of external abdominal hernia. along with the breakthrough progress in the mesh treatment of external abdominal hernia, According to the chemical composition and biological characteristics, the patch materials can be divided into non-absorbable materials, absorbable materials, composite repair materials and biological materials. Methods In this paper, Pubmed database and Chinese journal full-text database literatures were searched,and all mesh materials used in inguinal hernia repair were comprehensively studied, summarized and analyzed in clinical application.
Keywords: external abdominal hernia; patch material; conclusion; application
Inflammatory Bowel Disease and Diabetes: An Association in Horizon
Authors: Das Avik , Chandra Srikanta , Samanta Jyotirmay , Bose Preeta , Roy Tathagata , Mukherjee Lucky 
Published: September 2019

As we know inflammatory bowel disease is an emergent plight in rural and developing countries. In USA 10 million of peoples are suffering from IBD.IBD encompasses two pivotal kinds of pathological condition Ulcerative colitis (UC) and Crohn’s disease (CD). Epidemiologically has a greater prevalence in the global prospective. So we decided to zero in on IBD in our work ahead. So a thorough search of available literature IBD is associated with plethora of comorbid disorders which includes gastrointestinal disorders arising from cholelithiasis, cutaneous disease like psoriasis, metabolic disorders like diabetes mellitus.
Keywords: IBD: inflammatory bowel disease, CD: Crohn’s disease, UC: Ulcerative colitis,
Importance of “Kent Repertory” and “concept of Modality” towards the analysis of case of Diseases
Authors: Anpat Ashok V. , Kavishwar Viplav N. 
Published: September 2019

The use of homoeopathic medicine requires skilful observation of specific characteristics feature of case of disease, to resolve it within the shortest period of time. While dealing with acute as well as chronic cases, requires focus attention of homeopathic physician on characteristic features of the case. Modalities are the one of the characteristic symptoms which helps to find prescribing totality in the case of disease. Most of the time these characteristic features are voluntarily narrated by patient himself or observed by homoeopathic physician. In this regards the homoeopathic text named 'repertory of homoeopathic materia medica' offers better and easy way to find the rubric of modalities within shortest period of time that helps to examine specific cases appropriately. Present article described the importance of “Kent repertory” and concept of modalities towards the analysis of case of diseases.
Keywards: Homoeopathic, Modalities, Materia Medica, Repertory
Tip 2 Diyabetli Hastalarda Diş Çürüğü, Endodontik Tedavi ve Apikal Periodontitis Prevalansı: Kesitsel Çalışma
Authors: KURNAZ Safa , TAŞKINSEL Ertan 
Published: September 2019

Amaç:
Bu kesitsel çalışmada tip 2 diyabetli hastalardaki çürük, dolgu, kron, kök
kanal tedavisi, apikal periodontitis prevalansı ve ağızdaki toplam diş
sayısının sağlıklı bireyler ile karşılaştırılması amaçlanmıştır.

Materyal-Metot:
Bu retrospektif çalışmada 50 adet tip 2 diyabetli hasta ile 50 adet sağlıklı
bireyin panoramik radyografileri incelendi. Çalışmaya toplam 58 erkek, 42 kadın
dahil edildi. Sağlıklı bireylerin yaş ve cinsiyetleri diyabetik bireylerle her
hasta için aynı olacak şekilde eşleştirildi. Her iki grupta, bireylerdeki
ağızda bulunan çürük, dolgu, kron, kök kanal tedavisi, apikal periodontitis ve
toplam diş sayıları tespit edildi. Elde edilen değerler iki grup arasında
karşılaştırıldı. Veriler istatistiksel olarak ki-kare ve Mann-Whitney U
testleri ile değerlendirildi ve verilerin karşılaştırılmasında p&lt;0,05
anlamlılık düzeyi olarak kabul edildi.

Bulgular:
Tip 2 diyabetli ve kontrol grubu arasında çürük diş sayıları ve apikal
periodontitisli diş sayılarında istatistiksel olarak anlamlı farklılık görüldü
(p&lt;0,05). İki grup arasındaki apikal periodontitis sayısının kanal tedavili
dişlerdeki ve kanal tedavisi yapılmamış dişlerdeki sayıları ayrı olarak
incelendiğinde bu farklılığın kanal tedavisi yapılmamış dişlerde görülen yüksek
apikal periodontitis prevalansından kaynaklandığı gözlendi. İki grup arasındaki
diğer parametrelerde ise istatistiksel olarak anlamlı farklılık bulunmadı
(p&gt;0,05).

Sonuç:
Bu çalışmanın sonuçlarına göre çürük diş ve apikal periodontitis prevalansı tip
2 diyabetik bireylerde daha yüksektir. Tip 2 diyabet kök kanal tedavisinin
başarısını olumsuz yönde etkilememektedir.