bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Study on Lipid Profile Status In Hypothyroid Patients And Its Consequences
Authors: Sarkar Mohammad Abdus Sattar , Salma Umma , Rahman Motlabur , Mahbub Tania , Shahi Selim , Khanam Shahana , Azhar Md Abu 
Published: November 2024

This cross-sectional study was conducted to compare lipid profile status in hypothyroid patients attending at indoor and outpatient Department (OPD) of Medicine and Endocrinology, Sir Salimullah Medical College & Mitford Hospital, Dhaka over a period 6 months from March to September 2008. A total of 80 patients (of which 30 patients formed the control group) aged 12 to 60 years, not taking thyroxin in the last 3 months and not taking lipid lowering agents were included in the study. Patients with secondary hypothyroidism, chronic renal failure, liver diseases, pregnancy, dyslipedamia (with or without lipid lowering agents) were excluded from the study. Data collected on variables of interest were analyzed using Chi-squared (c2) or Fisher`s Exact Probability tests, Student’s t-test and person correlation co-efficient test was done to see the correlation of lipid profile with the severity of hypothyroidism. The mean value of TSH, total cholesterol, low-density lipoprotein cholesterol (LDL-C) and triglyceride in case group were significantly higher than those in control group but the mean high density lipoprotein cholesterol (HDL-C) was lower in case group compared to control group. The findings of the study indicate that THS shows positive correlation with total cholesterol, LDL cholesterol and triglyceride (r = 0.025, p = 0.865, r = 0.258, p = 0.071 and r = 0.078, p = 0.589 respectively) and HDL cholesterol exhibiting a negative correlation (r = -0.055, p = 0.704). These results confirm that thyroid dysfunction is common, and may be associated with adverse health outcomes.
J. Dhaka National Med. Coll. Hos. 2013; 19 (02): 4-8
Pelatihan Pembuatan Media Komunikasi Visual sebagai Media Promosi di Tempat Wisata Sumberingin Kecamatan Tumpang Kabupaten Malang
Authors: Joni Dwi Pribadi  , Fullchis Nurtjahjani  , Heru Utomo  , Mahmudatul Himma  , Ane Fany Novitasari  , Abd Muqit  
Published: November 2024

Tempat Wisata Alam Pemandian Sumberingin Kecamatan Tumpang, Kabupaten Malang terletak 2 km dari jalan utamamenuju tempat wisata. Pada saat wisatawan berkunjung ke tempat wisata mengalami kesulitan sampai ke tempat tujuan dan waktu yang dibutuhkan oleh wisatawan untuk berkunjung ke Tempat Wisata Alam Pemandian Sumberingin tidak efektif dan tidak efisien. Untuk mengatasi permasalahan, yaitu 1.) Membuat media komunikasi visual berupa papan nama dan penunjuk arah menuju Tempat Wisata Alam Pemandian Sumberingin, 2.) Memilih lokasi yang tepat untuk pemasangan papan nama dan penunjuk arah menuju Tempat Wisata Alam Pemandian Sumberingin. Kegiatan Pengabdian Pada Masyarakat meliputi pemilihan tempat untuk pemasangan papan nama dan penunjuk arah serta mendesain modelnya yang menarik dan mudah dipahami oleh wisatawan. Desain papan nama dan penunjuk arah dibuat dengan persetujuan bersama dengan pihak mitra. Kemudian, dilakukan pemasangan papan nama dan penunjuk arah ditempat yang telah dipilih oleh mitra. Dengan memberikan pelatihan pembuatan media komunikasi visual berupa papan nama dan petunjuk arah diharapkan dapat memperjelas Wisatawan berkunjung ke tempat wisata dengan cepat dan tepat sampai ke Tempat Wisata Alam Pemandian Sumberingin. Selanjutnya pembuatan papan nama dan penunjuk arah yang baik dan jelas merupakan salah satu media promosi penjualan

Kata kunci: Media Komunikasi Visual, Promosi, Wisata Alam
Prevalence and risk factors of mortality among heart failure patients in low resource setting hospitals: a multicenter prospective observational study
Authors: Bekele Firomsa , Sheleme Tadesse , Tsegaye Tesfaye , Parameswari S. Angala , Syed Manjoor Ahamad , Tafese Lalise , Gezimu Wubishet 
Published: November 2024

BackgroundHeart failure is a significant worldwide health problem that leads to mortality. Therefore, this study aimed to evaluate treatment outcomes and associated factors of heart failure patients who were admitted to hospitals in the southwest of Ethiopia.Methods and participantsA multicenter prospective observational study was conducted from 1 February to 1 August 2021. Drug therapy problems were assessed as per the Cipolle, Strands, and Morley drug therapy problems classification method. The drug therapy was registered by using the drug-related problem registration format. The results of logistic regression analysis was interpreted as crude odds ratio and adjusted odds ratio (AOR) at 95% confidence interval (CI) to determine the association between dependent and independent variables.ResultsIn our study settings, a total of 205 (85.1%) heart failure patients showed improvement and 36 (14.9%) died at hospital discharge. Being ≥65 years (AOR = 7.14, 95% CI: 2.04–.25.01, P = 0.002), a previous hospitalization (AOR = 6.20, 95% CI: 1.81–21.21, P = 0.004), and the presence of medication-related problems (AOR = 3.65, 95% CI: 1.13–11.73, P = 0.03) were the predictors of mortality.ConclusionThe prevalence of in-hospital mortality among heart failure patients was found to be high. Previous hospitalization, older age, and the presence of drug therapy problems were the predictors of mortality among heart failure patients. Therefore, proper attention should be given to the management of elderly and re-admitted heart failure patients in addition to their regular care. In addition, hospitals should implement clinical pharmacy services to address any drug-related problems.
Safety and efficacy of intracardiac echocardiography-guided zero-fluoroscopy ablation in atrial fibrillation patients: a comparative study of high-power short-duration and low-power long-duration strategies
Authors: Liu Guang-an , Shao Bo , Wu Wanglong , Zhou Linxiao , Cui Jing , Chen Wenxue , Zhang Ruoxi , Liu Feng 
Published: November 2024

IntroductionIn atrial fibrillation (AF) ablation, fluoroscopy has been a standard tool for catheter guidance. However, the combination of electroanatomic mapping systems (EAMs) and intracardiac echocardiography (ICE) now allows for minimal or zero-fluoroscopy procedures. Concurrently, high-power short-duration (HPSD) ablation has emerged as a promising technique, offering enhanced resistive heating while reducing conductive heating. This approach potentially improves both safety and efficacy. Despite these advancements, there is a lack of comprehensive clinical data on the safety and effectiveness of HPSD ablation when used in conjunction with ICE-guided zero-fluoroscopy procedures.ObjectiveTo compare two different ablation strategies—high-power short-duration (HPSD) and low-power long-duration (LPLD)—both utilizing intracardiac echocardiography (ICE)-guided zero-fluoroscopy in the context of atrial fibrillation (AF) ablation.MethodsThis retrospective study included 173 consecutive patients with AF who underwent ICE-guided zero-fluoroscopy ablation. Patients were divided into two groups: HPSD and LPLD. All procedures were conducted using an EAM system with ICE guidance. Both groups underwent routine pulmonary vein isolation (PVI), with additional linear ablations performed for persistent AF when necessary. We compared treatment outcomes and the incidence of complications between the two groups.ResultsAll procedures were successfully completed under ICE-guided zero-fluoroscopy, establishing a feasible and reliable workflow. The procedure and ablation times were significantly shorter in the HPSD group compared to the LPLD group. At one-year follow-up, sinus rhythm was maintained in 77 patients in the HPSD group and 74 patients in the LPLD group, with no significant difference between the two group. Postoperative complications occurred in 5 patients in the HPSD group and 3 patients in the LPLD group. Importantly, there were no major adverse cardiac and cerebrovascular events (MACCE) in either group.ConclusionA zero-fluoroscopy workflow utilizing an EAM system combined with ICE appears to be both feasible and safe for ablation in AF patients. In patients undergoing ICE-guided zero-fluoroscopy ablation, the HPSD strategy is comparable to LPLD ablation in effectiveness while offering the benefit of shorter procedure and ablation times.
Identification of oxidative stress-related biomarkers in uterine leiomyoma: a transcriptome-combined Mendelian randomization analysis
Authors: Li Yingxiao , Chen Haoyue , Zhang Hao , Lin Zhaochen , Song Liang , Zhao Chuanliang 
Published: November 2024

BackgroundOxidative stress has been implicated in the pathogenesis of uterine leiomyoma (ULM) with an increasing incidence. This study aimed to identify potential oxidative stress-related biomarkers in ULM using transcriptome data integrated with Mendelian randomization (MR) analysis.MethodsData from GSE64763 and GSE31699 in the Gene Expression Omnibus (GEO) were included in the analysis. Oxidative stress-related genes (OSRGs) were identified, and the intersection of differentially expressed genes (DEGs), Weighted Gene Co-expression Network Analysis (WGCNA) genes, and OSRGs was used to derive differentially expressed oxidative stress-related genes (DE-OSRGs). Biomarkers were subsequently identified via MR analysis, followed by Gene Set Enrichment Analysis (GSEA) and immune infiltration analysis. Nomograms, regulatory networks, and gene-drug interaction networks were constructed based on the identified biomarkers.ResultsA total of 883 DEGs were identified between ULM and control samples, from which 42 DE-OSRGs were screened. MR analysis revealed four biomarkers: ANXA1, CD36, MICB, and PRDX6. Predictive nomograms were generated based on these biomarkers. ANXA1, CD36, and MICB were significantly enriched in chemokine signaling and other pathways. Notably, ANXA1 showed strong associations with follicular helper T cells, resting mast cells, and M0 macrophages. CD36 was positively correlated with resting mast cells, while MICB was negatively correlated with macrophages. Additionally, ANXA1 displayed strong binding energy with amcinonide, and MICB with ribavirin.ConclusionThis study identified oxidative stress-related biomarkers (ANXA1, CD36, MICB, and PRDX6) in ULM through transcriptomic and MR analysis, providing valuable insights for ULM therapeutic research.
Moderating effects of body composition biomarkers on the relationship between thyroid hormones and cognitive performance in euthyroid older adults: insights from NHANES data
Authors: Li Xiaosong , Duan Hongliang , Liu Shuang , Li Hanyang , Zhang Hong 
Published: November 2024

BackgroundThyroid hormones are essential for cognitive function and can impact cognitive performance even in euthyroid individuals. This study investigates how thyroid hormones influence cognitive performance in the elderly and whether body composition biomarkers moderate this relationship. The aim is to determine if lifestyle interventions should prioritize weight loss, overall body fat reduction, or abdominal fat loss.MethodsWe analyzed data from the NHANES 2011-2012 dataset, focusing on thyroid hormone levels, cognitive performance, and body composition metrics in euthyroid individuals aged 60 to 80 years. A total of 573 participants were included in the analysis. Pearson correlation analyses were conducted to evaluate the associations between thyroid hormone indicators and cognitive performance metrics. Ordinal logistic regression and linear regression analyses were used to determine the predictive capacity of thyroid hormones on cognitive functions, adjusting for potential confounders such as age, gender, and education level. Statistical analyses were performed using R Studio and Stata, utilizing Pearson correlation, ordinal logistic regression, and linear regression methods.ResultsSignificant correlations were observed between short-term memory and TT3 (r = 0.111, p = 0.018), TSHI (r = -0.121, p = 0.010), and TFQI (r = -0.107, p = 0.023); delayed memory and FT3 (r = 0.143, p = 0.003), TT3 (r = 0.146, p = 0.002), and TSHI (r = -0.125, p = 0.009); and executive function with FT4 (r = -0.141, p = 0.003) and the FT3/FT4 ratio (r = 0.137, p = 0.004). Although thyroid indicators did not independently predict short-term memory (OR = 0.006, p = 0.116), they were statistically significant for delayed memory with FT3 (OR = 0.642, p = 0.017) and TT3 (OR = 0.010, p = 0.015). Linear regression analysis indicated that FT4 (t = -2.99, p = 0.003) and the FT3/FT4 ratio (t = 2.91, p = 0.004) were significant predictors of executive function. Hierarchical regression analyses revealed that BMI and waist circumference (WWI) significantly moderated the relationship between thyroid function and short-term memory (BMI: z = 2.44, p = 0.015; WWI: z = -2.19, p = 0.029). BMI also moderated the models for delayed memory (z = 2.11, p = 0.035), while RFM and C-index did not exhibit significant moderating effects. No moderators were identified in the relationship between executive function and thyroid hormones.ConclusionThis study underscores the significant influence of higher BMI and waist circumference on the relationship between thyroid function and memory performance. In contrast, body composition indicators such as RFM and C-index do not appear to significantly affect cognitive function related to thyroid levels, highlighting the importance of fat distribution in cognitive health assessments.
USA-Mexico border wall impedes wildlife movement
Authors: Harrity Eamon J. , Traphagen Myles , Bethel Meagan , Facka Aaron N. , Dax Michael , Burns Emily 
Published: November 2024

Geopolitical boundaries can present challenges to wildlife conservation because of varying environmental regulations, and increasingly, the existence of border barriers. As of 2024, approximately 1,023 km of border walls (i.e., steel bollard walls 5.5-9.1 m tall with interstitial spaces ≤10 cm) and 169 km of vehicle barriers (i.e., variable steel structures designed to stop vehicles but not pedestrians) exist along the USA-Mexico border. Some small wildlife passages (21.5 x 27.8 cm) were installed in border walls but few other accommodations for wildlife connectivity exist. As such, ecological consequences of border barriers may be severe and documenting the ability of wildlife to traverse these barriers will be essential to conservation efforts. We placed 36 wildlife cameras across 163.5 km of the USA-Mexico border in Arizona, USA and Sonora, MX to evaluate crossing rates through border barriers for 20 terrestrial species. We observed 9,240 wildlife events, including 1,920 successful crossing events. All focal species crossed through vehicle barriers, whereas white-tailed deer, mule deer, American black bear, American badger, wild turkey, and mountain lion appeared unable to cross through interstitial spaces in border walls. Small wildlife passages improved crossing rates for several species, including American badger, collared peccary, coyote, and mountain lion. Yet, small wildlife passages were scarce with only 13 along &gt;130 km of continuous border wall and failed to allow American black bear, deer, and wild turkey to cross. Additional research on the impacts of border barriers and potential mitigation strategies will be critical for effective transboundary conservation.
Construction and implement of hierarchical management system for specialist nurses based on Patricia Benner’s theory
Authors: Yu Haiyan , Chen Yuan , Wu Linjing , Wang Ligang , Lai Yuting , You Aijun 
Published: November 2024

ObjectiveTo construct a hierarchical management system for specialist nurses based on Patricia Benner’s theory, and evaluate its implement effect, so as to provide reference for the hierarchical management of specialist nurses.MethodsLiterature retrieval, semi-structured interview and Delphi method were conducted for initially formulation of the draft of hierarchical management system for specialist nurses. Forty-three specialist nurses and 14 nursing managers were selected for the study, using a non-randomized controlled experimental study design, and at the end of the study, the job satisfaction, job engagement, job exuberance, advice behaviors and nursing managers’ overall job satisfaction of specialist nurses were compared before and after the hierarchical management.ResultsThis study constructed a hierarchical management system for specialist nurses. The differences in specialist nurses’ job satisfaction, job engagement, job exuberance and constructive behaviors before and after hierarchical management were statistically significant (p &lt; 0.05), and the differences in the nursing managers’ assessment of specialist nurses’ overall job satisfaction were statistically significant (p &lt; 0.05).ConclusionThe hierarchical management system of specialist nurses based on Patricia Benner’s theory improves the quality of hierarchical management of specialist nurses, which could improve the job satisfaction of specialist nurses. The system could provide guidance and reference for hierarchical management system of specialist nurses.
Survey of probable synergism between melittin and ciprofloxacin, rifampicin, and chloramphenicol against multidrug-resistant Pseudomonas aeruginosa
Authors: Sedaghati Mahsa , Akbari Reza , Lotfollahi Hagghi Lida , Yousefi Saber , Mesbahi Tahere , Delfi Mahdieh 
Published: November 2024

BackgroundThe emergence of multidrug-resistant bacteria and also biofilm-associated infections is a great health concern due to the failure of available antibiotics. This has alerted scientists to developing alternative antibiotics. Melittin as an antimicrobial peptide has antibacterial synergistic activity in combining with conventional antibiotics against pathogenic bacteria. Accordingly, this study aimed to assess the synergistic effect of melittin in combination with Ciprofloxacin, Rifampicin, and Chloramphenicol against MDR strains of P. aeruginosa.Materials and methodsFifty strains of P. aeruginosa were isolated from clinical specimens. The antibiotic susceptibility of isolates was evaluated by the disk diffusion method. The MIC and MBC of melittin and melittin-antibiotics combination against isolated strains were examined by microdilution method. The probable synergism between melittin and antibiotics was assayed using the FIC protocol. Time-killing kinetics and anti-biofilm effects of melittin and melittin-antibiotics combination were evaluated using time-kill kinetics and crystal violet staining method, respectively. The toxicity of the melittin-antibiotics combination on the HEK293 cell line was also assessed by the MTT assay method.ResultsOut of 50 isolates of P. aeruginosa, 15 strains are considered to be multidrug strains. Among MDR strains of P. aeruginosa, 42.85% were resistant to cefepime and ceftazidime and all urine-originate isolates were resistant to cotrimoxazole. A combination of MIC dose of ciprofloxacin and melittin decreased resistance against ciprofloxacin up to 33%. The ciprofloxacin-melittin combination showed a favorable synergism and anti-biofilm effect and was also 30.3% less toxic than melittin alone at 4 μg/ml against the HEK293 cell line. In contrast to ciprofloxacin, with the melittin-rifampicin and melittin-chloramphenicol combinations, an addition effect occurred, respectively, in 86.66 and 53.33% of MDR strains of P. aeruginosa.ConclusionCombining melittin’s antibacterial and anti-biofilm properties with traditional antibiotics may offer a novel strategy to address antibiotic resistance in P. aeruginosa. The simultaneous administration of melittin and ciprofloxacin in a single dose has shown a marked increase in antibacterial effectiveness while minimizing toxicity to the HEK293 cell line. It is advisable to conduct additional research to explore the combined antibacterial effects of melittin and ciprofloxacin in a wider range of clinical samples, animal models, and clinical trial settings.
Abnormal eye movements: relationship with clinical symptoms and predictive value for Alzheimer’s disease
Authors: Qi Jing , Lian Tenghong , Guo Peng , He Mingyue , Li Jinghui , Li Jing , Luo Dongmei , Zhang Yanan , Huang Yue , Liu Gaifen , Zheng Zijing , Guan Huiying , Zhang Weijia , Yue Hao , Liu Zhan , Zhang Fan , Meng Yao , Wang Ruidan , Zhang Wenjing , Zhang Wei 
Published: November 2024

BackgroundAbnormal eye movements occur at the early stages of Alzheimer’s disease (AD). However, the characteristics of abnormal eye movements of patients with AD and their relationship with clinical symptoms remain inconsistent, and their predictive value for diagnosing and monitoring the progression of AD remains unclear.MethodsA total of 42 normal controls, 63 patients with mild cognitive impairment due to AD (AD-MCI), and 49 patients with dementia due to AD (AD-D) were recruited. Eye movements were assessed using the EyeKnow eye-tracking and analysis system. Cognitive function, neuropsychiatric symptoms, and activities of daily living were evaluated using various rating scales, and correlation analyses and receiver operating characteristic curves were performed.ResultsPatients with AD exhibited increased number of offsets and offset degrees, prolonged offset duration, and decreased accuracy in lateral fixation; reduced accuracy, prolonged saccadic duration, and decreased velocity in prosaccade; decreased accuracy and corrected rate, prolonged corrected antisaccadic duration, and reduced velocity in antisaccade; and reduced accuracy and increased inhibition failures in memory saccade. Eye movement parameters were correlated with global cognition and the cognitive domains of memory, language, attention, visuospatial ability, execution function, and activities of daily living. Subgroup analysis indicated that the associations between eye movements and clinical symptoms in patients with AD were influenced by disease severity and history of diabetes. In the AD-D and AD with diabetes groups, these associations diminished. Nevertheless, the associations persisted in the AD-MCI and AD without diabetes groups. The areas under the curves for predicting AD, AD-MCI, and AD-D were 0.835, 0.737, and 0.899, respectively (all p &lt; 0.05).ConclusionPatients with AD exhibit distinct patterns of abnormal eye movements. Abnormal eye movements are significantly correlated with global cognition, multiple cognitive domains, and activities of daily living. Abnormal eye movements have a considerable predictive value for the diagnosis and progression of AD.