bluuebunny/crossref_metadata_2025_split huggingface dataset:
Needs and presence of temporary migrant workers in the regions of Quebec (Canada): From public data to a unified database
Authors: Frozzini Jorge , Arnaud Vincent 
Published: December 2024

Background During the recent years of labour shortage, many employers and employer associations have been calling for the recruitment of more temporary migrant workers (TMW) in the province of Quebec. The various programs, the needs expressed by employers, and the problems encountered by TMWs remain largely unknown to the structures that receive these workers (municipalities, Regional County Municipalities or RCM …) or help them (associations …). The real number of TMWs in each local territorial division (Administrative regions, RCM and municipalities) remains unknown. It is therefore difficult to develop welcoming policies or an inclusive framework that meets the needs of these populations. Objective To develop a more detailed knowledge of the presence of TMWs in Quebec and the needs expressed by employers. Methods Design of a unified database to elaborate a statistical portrait of the needs expressed by employers and the presence of TMWs in the province of Quebec by stream of the Temporary Foreign Worker Program (TFWP), by skill level, and by territory from 2017 to 2022. An exploratory data analysis to summarize the main characteristics of this longitudinal sample using statistical graphics and maps was conducted. Results There are substantial differences between regions and their territories regarding the streams of the TFWP, occupations and skills needed. The data also illustrate the prominence of some companies who hire a large number of TMWs in the province of Quebec and the effect of the COVID-19 lockdowns. Conclusion Our analysis shows an increase of various types of TMWs in specific administrative regions and a gap in statistical data about workers from the TFWP for the organizing efforts of local environments (RCM, municipalities and their community sector) to respond to the needs of a growing number of these workers.
Why consider trauma in vocational rehabilitation? Insights from cognitive model of PTSD and self-determination theory
Authors: Kim Jaeyoung , Lee Minju , Choi Heerak , Zhou Kaiqi , Tansey Timothy N 
Published: December 2024

Background Individuals with disabilities are at an increased risk of trauma exposure. The cognitive model of posttraumatic stress, combined with Self-Determination Theory (SDT), provides a useful conceptual framework for understanding how trauma exposure leads to reduced basic psychological needs satisfaction at the work. Objective This study aims to investigate the structural relationships among trauma exposure, posttraumatic cognition, and basic psychological need satisfaction at workplace, showing how traumatic experiences of employees with chronic illness and disabilities (CID) affects their basic psychological needs fulfillment at work, with posttraumatic beliefs as a mediator. Method An online survey of 183 participants with CID was analyzed using structural equation modeling. Two competing models were compared to determine the model with better fit. The selected model was then examined for structural validity and coefficient estimations. Results The full mediation model was selected with strong measurement structures. Path estimations revealed that increased trauma exposure has a negative indirect effect on basic psychological needs, fully mediated by increased posttraumatic cognitive beliefs. Conclusion Trauma exposure and associated cognitive distortions can create significant barriers to successful work outcomes for individuals with CID. Integrating trauma-informed care into vocational rehabilitation (VR) services may help mitigate these challenges and support successful VR outcomes.
Insights on turnover intent in state vocational rehabilitation agencies
Authors: Landon Trenton J , Phillips Brian N , McKnight Michelle , Sabella Scott A , Kline Kate M , Poe Melanie , Lockett Marissa 
Published: December 2024

Background The state vocational rehabilitation (VR) system has a long history as a leading public program serving individuals with disabilities. Hundreds of vocational rehabilitation counselors work in each of the 78 agencies representing every state and territory in the United States. However, chronic issues of employee turnover have served as a disruptor to vocational rehabilitation services while adding costs to the program for more than two decades. Turnover adds to the difficulty of maintaining a healthy work climate and serves to weaken agencies. Objective The aim of this brief report was to characterize the turnover phenomenon in state VR agencies and provides a synopsis of research findings indicating causes for the turnover. Methods A review and synthesis of the empirical literature presently available on turnover in state VR settings is provided. Results Although this brief report is a synopsis of research examining the turnover phenomena presently experienced by state VR agencies, many of the reasons qualified providers of VR services are leaving have remained consistent over the past two decades. Conclusion Recommendations are provided in an effort to support VR agency leadership in their recruitment and planning efforts to retain qualified providers.
Post-stroke cognitive impairment impact on motor rehabilitation: A historical cohort study
Authors: Silva Andreia , Vaz Mário , Pinto Luísa , Dias João , Azevedo Marta , Fontoura Janina , Carvalho João , Amorim Sofia , Silva Maria João , Nunes Renato 
Published: December 2024

Background Cognitive dysfunction is a common post-stroke sequelae with a negative impact on patient's functional independence. Objective Investigate the impact of post-stroke cognitive impairment on motor rehabilitation in the subacute phase, with a particular focus on executive functioning deficit. Methods A historical cohort was based on 145 clinical records over a period of 3 years and 5 months. A formal assessment of cognitive function was performed, using Montreal Cognitive Assessment (MoCA), INECO frontal screening (IFS) test and/or subtests of the Wechsler Adult Intelligence Scale (WAIS-III). Motor recovery was evaluated through the evolution of the motor Functional Independence Measure (FIM). Results Out of 145 included patients, 105 manifested post-stroke cognitive dysfunction (72.4%). Patients with mild or moderate stroke were most likely to present cognitive deficits (31.4% and 54.3%, p < .001). The most impaired domain was executive function (79%), manifested in isolation (20%) or combined (59%). In mild stroke, the difference between motor FIM at discharge and admission was significantly lower in the group of patients with isolated executive functioning deficit ( p = .027). Conclusions Isolated executive functioning impairment had a negative impact on motor recovery in mild stroke. No significant association was found between global cognitive dysfunction and the motor function evolution after stroke.
Bilingual language experience and code-switching acceptability judgments: A constructive replication of the work by Stadthagen-González et al. (2019), Balam et al. (2020), and Stadthagen-González et al. (2018)
Authors: Olson Daniel J. 
Published: December 2024

Aims and objectives: While a significant body of research has examined bilinguals’ preferences with respect to the acceptability of different structures in intrasentential code-switching, this line of work has largely ignored the potential effect of language experience on bilinguals’ judgments. Within bilingual language experience, two particular variables have garnered significant attention: language dominance and code-switching experience. The current study presents a constructive replication of three prior studies and examines the potential modulating role of language experience. Design/methodology: Seventy-one Spanish–English bilinguals participated in a constructive replication of three previously published studies. Experiment 1, replicating the study by Stadthagen-González et al. (2019), examines comparative judgments of noun–adjective order. Experiment 2, replicating the work of Balam et al. (2020), analyzes bilingual verbs. Experiment 3, replicating the study by Stadthagen-González et al. (2018), examines the adjacency condition. Bilinguals provided code-switching judgments via a two-alternative forced-choice (2AFC) task and information about their language experience via a language-dominance questionnaire and a code-switching experience questionnaire. Data and analysis: Relative rankings of the different bilingual constructions, using Thurstone’s law of comparative judgments, allowed for comparison with previous studies. The effect of language dominance and code-switching experience was assessed using binomial logistic regressions. Findings/conclusions: Broad agreement with results from each of the replicated studies was found. In addition, results show a significant impact of language dominance on acceptability judgments across all three experiments and an impact of code-switching experience in one of the three experiments. Originality: This study responds directly to an ongoing call for replication studies in the field of bilingualism and is among the first to consider the role of prior language experiences on acceptability judgments. Significance/implications: The strong replicability of prior results serves to support prior findings in the literature. Moreover, this study highlights the potential impact of prior linguistic experiences, including language dominance and code-switching experience, on bilingual behaviors.
Do L2 learners show attachment preferences? The processing of participial relative clauses in L2 Russian by English–Russian bilinguals
Authors: Luk Zoe Pei-sui , Darzhinova Liubov 
Published: December 2024

Aims and objectives: This study investigated whether first language (L1) English and second language (L2) Russian bilinguals are sensitive to structural information during L2 processing by testing their attachment preference when reading participial relative clauses with three preceding noun phrases in Russian. Methodology: The participants read sentences containing a participial relative clause preceded by three noun phrases connected by genitive marking and responded to comprehension questions by indicating which noun phrase the participial relative clause modified or that the sentence was ungrammatical. Their reading times and post-reading responses were recorded. Data and analysis: The reading times were log-transformed and fitted to a generalized linear mixed-effects model. Ungrammaticality judgment rates and noun phrase selection accuracy rates were fitted to generalized linear mixed-effects models using a binary logistic distribution. Findings: Reading times and ungrammaticality judgment rates showed that the participants preferred to attach the participial relative clause to the first and the third noun phrases. The second noun phrase was least preferred. These results contrast findings in previous studies, which have shown no attachment preference for L2 learners. We argue that the participants were sensitive to structural information, in that they were constrained by the recency preference and the predicate proximity effects, similar to native speakers. Originality: To the best of our knowledge, this is the first study that tested L2 learners with relative clauses preceded by three noun phrases and showed that L2 learners are also constrained by the recency preference and predicate proximity effects. Significance/Implications: We argue that our findings deviate from the null attachment preference found in previous studies, which has been used as evidence that L2 processing is fundamentally different from L1 processing. Our findings suggest that L2 learners were influenced by predicate proximity, similar to native Russian speakers, and were also mildly influenced by recency preference, which could be from this L1.
World Stroke Organization: Global Stroke Fact Sheet 2025
Authors: Feigin Valery L , Brainin Michael , Norrving Bo , Martins Sheila O , Pandian Jeyaraj , Lindsay Patrice , F Grupper Maria , Rautalin Ilari 
Published: December 2024

Background: Among non-communicable disorders (NCDs), stroke remains the second leading cause of death and the third leading cause of death and disability combined (as expressed by disability-adjusted life-years lost—DALYs) in the world. Aims: The study was aimed to estimate global, regional and nationa burden of stroke and its risk factors from 1990 to 2021. Methods: Finding presented in this paper were derived mainly from the Global Burden of Disease 2021 Study on stroke burden published in The Lancet Neurology 2024:23:973-1003. Results: The estimated global cost of stroke is over US$890 billion (0.66% of the global GDP). From 1990 to 2021, the burden (in terms of the absolute number of cases) increased substantially (70.0% increase in incident strokes, 44.0% deaths from stroke, 86.0% prevalent strokes, and 32% DALYs), with the bulk of the global stroke burden (87.0% of deaths and 89.0% of DALYs) residing in lower-income and lower-middle-income countries (LMICs). Stroke attributable to metabolic risks constituted 69.0% of all strokes, environmental risks constituted 37.0%, and behavioral risks constituted 35.0%. Conclusion: This World Stroke Organization (WSO) Global Stroke Fact Sheet 2025 provides the most updated information that can be used to inform communication with all internal and external stakeholders; all statistics have been reviewed and approved for use by the WSO Executive Committee and leaders from the Global Burden of Disease research group.
HIV Preexposure Prophylaxis Practice among Urban Female Sex Workers in Northwest Ethiopia: Using Generalized Structural Equation Modeling
Authors: Asmare Lakew , Goshu Atalay , Alemu Tihtna , Gebeye Ejigu 
Published: December 2024

Background Acquired immunodeficiency syndrome, caused by the human immunodeficiency virus, has remained a public health threat for the last decades with significantly high burden. Despite the introduction of various human immunodeficiency virus (HIV) prevention strategies targeting high-risk populations, including preexposure prophylaxis, there remains a notable gap in the literature regarding Pre-Exposure Prophylaxis (PrEP) practice among female sex workers (FSWs) in Ethiopia, particularly using advanced analytical methods like structural equation modeling. This study aimed to assess practice and associated factors of preexposure prophylaxis among urban female sex workers in Northwest Ethiopia. Methods A cross-sectional study was carried out at organizations of Organizations for Social Service, Health Development, Mehabere Hiwot for Social Development, and African Network for the Prevention and Protection Against Child Abuse and Neglect that serve FSWs. Systematic random sampling technique was employed among 549 FSWs. An interviewer-administered questionnaire was used to collect the data. Generalized structural equation modeling was employed to identify factors associated with PrEP practice. As the mediation of effects was present, the direct, indirect, and total effects were determined. A final model was selected based on the statistical significance of the path coefficient. Results In this study, the practice of preexposure prophylaxis was 28.00% with 95% CI = 25.34% to 32.72%. Thus, female sex workers with an education level of college and above had both direct and indirect positive effects on PrEP practice when mediated by knowledge, knowledge had both direct and indirect effects on PrEP practice when mediated by attitude. Whereas, FSWs who had duration of sex work for 3 to 5 years had only a positive direct effect on PrEP practice compared to those who were living in sex work for less than three years duration. Conclusion However, HIV remains a public health problem, and the practice of preexposure prophylaxis in this study was found to be low. FSWs having higher education levels, attitudes, and knowledge demonstrate a significantly positive effect on their likelihood to practice PrEP. They suggested enhancing their health outcomes and reducing the risk of HIV transmission. The result of this study was also significant for communities that are serving in a given organization targeting integrated HIV testing and counseling services among key populations.
Validity and Reliability of the Turkish Version of the Medial Tibial Stress Syndrome Score
Authors: Demir Benli Merve , Winters Marinus , Arslan Aynur S. , Ceylan Ebru , Benli Cenk , Ergün Metin 
Published: December 2024

Background: Medial tibial stress syndrome (MTSS) is a common leg injury in military personnel and athletes and is especially related to running and jumping. A patient-reported outcome measure, the MTSS score, was developed to determine the severity of MTSS. Purpose: To translate, culturally adapt, and validate the MTSS score for the Turkish language. Study Design: Cohort study (diagnosis); Level of evidence, 2. Methods: Established guidelines were used for translation and adaptation. The Turkish version of the MTSS (MTSS-Tr) score was completed twice with a 1-week interval between assessments. In the first assessment, patients also completed the Turkish version of the 36-Item Short-Form Survey (SF-36-Tr) and a visual analog scale (VAS) for pain. Test-retest reliability and internal consistency of the MTSS-Tr were measured with the intraclass correlation coefficient (ICC) and Cronbach α coefficient, respectively. The construct validity was demonstrated with the Spearman correlation coefficient ( rS). Results: A total of 48 participants were included in the study. The test-retest reliability was good and internal consistency was good (ICC, 0.9; Cronbach α, 0.884). The MTSS-Tr score was highly negatively correlated with the physical component score of the SF-36-Tr ( rS = −0.716; P < .001). There was a moderate correlation between the MTSS-Tr score and the VAS pain score ( rS = 0.465; P = .001). Conclusion: The translated MTSS-Tr score has good internal consistency and good reliability and validity. Therefore, the MTSS-Tr score is useful to evaluate symptoms in patients with MTSS. Registration: NCT05400668 (ClinicalTrials.gov identifier).
Therapeutic Effect and Molecular Mechanism of the Ultra-Low Molecule Compound K on Multiple Myeloma
Authors: Shin Myung Geun , Kim Hye Ran , Lee Young Eun , Lim Ha Jin , Shin Jong Hee 
Published: December 2024

Introduction: Multiple myeloma (MM) is an incurable hematologic cancer that originates from plasma cells and occurs primarily in patients over 60. The prognosis of MM has improved after the introduction of new treatments, such as thalidomide, bortezomib, and lenalidomide. However, in recurrent and refractory MM patients, factors such as age and drug toxicity are important when choosing treatment options. Therefore, new drugs with little toxicity are needed. Through previous research, we confirmed that the triterpene compound series has a killing effect on multiple myeloma cells, and conducted a nonclinical trial.
Methods: The killing effect of the hit compounds on MM cell lines (ARH77, U266, and RPMI8226) was examined using a sulforhodamine B assay. Apoptosis mechanisms were investigated in vitro by western blot and apoptotic protein array. Complex immunocompromised mice were established by injecting RPMI8226-GFP-FLuc cells through the tail vein. Efficacy of the KBB-N1 activity was assessed following daily oral administration (20 mg/kg/day) for 3 weeks and tail vein (7 mg/kg/day) infusions for 3 days a week at daily intervals. Toxicity, pharmacokinetics, and molecular docking analyses were performed according to the established protocols.
Results: KBB-N1 was identified as an MM-targeted hit compound with cytotoxic effects. Severe suppression of normal hematopoietic stem cell function was observed with lenalidomide administration at a concentration of 25 μM. However, this toxicity was not observed when KBB-N1 was administered at doses up to 60 μM. KBB-N1 activity involves PARP cleavage and caspase activation in the apoptotic pathway. Furthermore, KBB-N1 inhibited cell growth and exerted cytotoxicity. KBB-N1 induced apoptosis by activating the P53 apoptosis pathway in MM cells. In vivo, all untreated tumor-bearing mice showed rapid tumor growth and severe plasmacytomas, which led to death within 7 weeks. Mice treated with KBB-N1 had significantly inhibited tumor growth and longer survival times. The molecular docking assay revealed the optimal docking conformation binding energy of KBB-N1 with docking scores (kcal/M) of -7.6 for phosphorylated p53.
Conclusions: This study demonstrated that KBB-N1, an ultra-low molecular weight ginsenoside compound K, effectively treated MM by increasing the expression of phosphorylated p53. Given its minimal toxicity to hematopoietic stem cells and major organs, KBB-N1 is a promising new drug for treating MM in older patients.
Erythropoietin-Induced Bone Loss Is Driven By an M-CSF Surge in the Bone Marrow As Assessed By Time-Course Studies in a Murine Model
Authors: Gorodov Anton , Kolomansky Albert (Alex) , Ben-Califa Nathalie , Lezerovich Lior , Piper Michelle , Gabet Yankel , Neumann Drorit 
Published: December 2024

Bone tissue constantly undergoes a process of remodeling that simultaneously involves bone resorption by osteoclasts and bone formation by osteoblasts. Osteoclasts are multinuclear cells that originate primarily from myeloid precursors, while macrophage colony-stimulating factor (M-CSF) is essential for their survival and differentiation. Osteoblasts originate from mesenchymal cells and differentiate into osteocytes (mineralized bone resident cells). The balance between bone resorption and bone formation determines changes in bone mass.
A wide variety of therapeutic interventions can affect bone metabolism. Erythropoietin (EPO), a primary regulator of red cell lineage, is commonly used in the clinic to treat anemia in certain clinical conditions and is sometimes administered to non-anemic patients before surgery to reduce the need for perioperative blood transfusion. We have previously shown that multidose (2-week) exposure to EPO significantly reduces bone mass in mice.
In this study, we explored the dynamics of the response to a single high-dose EPO treatment in bone and bone marrow (BM) microenvironment in mice. Bone parameters were examined at four time points (16 hours, 48 hours, 1 week, and 2 weeks) following a single EPO injection (180 U) in young (9 weeks) female mice. We found that this single dose of EPO led to a 32% decrease in bone volume/total volume (BV/TV) in the distal femur within 1 week, as assessed by µCT analysis. Serum M-CSF levels increased by 180% 16 hours after EPO administration. This increase was accompanied by a 2-fold increase in soluble M-CSF in the BM extracellular matrix, which returned to baseline levels 48 hours after EPO administration. M-CSF-receptor (CD115) positive cells in the BM increased by 32% and 39% 48 hours and 1 week following EPO injection, respectively. Osteoclast precursor cells (Lin− CD11b− Ly6Chi CD115+) increased by 32%, 32% and 46%, two days, 1 week and 2 weeks after EPO injection, respectively. In line with these findings, serum levels of tartrate resistance acid phosphatase 5b (TRAP5b), a marker of bone-resorbing osteoclasts, increased in EPO-treated mice by ~20% 1 week after EPO injection, compared to diluent injected controls. Bone formation was also significantly affected by EPO treatment, as reflected by a ~80% decrease in procollagen type I N-terminal propeptide (P1NP) within 48 hours after EPO injection and returned to baseline one-week post-treatment.
This study sheds light on the dynamic bone response to EPO, showing for the first time that even a single dose of EPO may have significant implications for bone metabolism. These findings are highly relevant in the case of EPO administration to non-anemic patients before surgery for potential avoidance of allogeneic transfusions.