bluuebunny/crossref_metadata_2025_split huggingface dataset:
Breast‐specific factors determine cosmetic outcome and patient satisfaction after breast‐conserving therapy: Results from the randomized COBALT study
Authors: Volders José H. , Negenborn Vera L. , Haloua Max H. , Krekel Nicole M.A. , Jóźwiak Katarzyna , Meijer Sybren , van den Tol Petrousjka M. 
Published: February 2018

Background and ObjectivesTo identify breast‐specific factors and the role of tumor, treatment, and patient‐related items in influencing patient opinion on cosmesis and satisfaction after breast‐conserving therapy (BCT).MethodsData from the randomized COBALT study was used. At 3, 12, and 36 months, 128 patients with T1‐T2 breast cancer completed a questionnaire on breast‐specific factors and overall cosmetic outcome and patient satisfaction, using a 4‐point Likert scale.ResultsThere was a strong positive correlation between breast‐specific factors, overall cosmetic outcome,and satisfaction at all time‐points. Excellent/good cosmetic outcomes and satisfaction decreased during follow‐up. A shift was noted in the degree of influence of the various breast‐specific factors. At 3 years, symmetry factors such as size, shape, and nipple position largely determined a patient's opinion on the final cosmesis, followed by firmness. The risk of an unacceptable outcome was associated with young age and large excision volumes.ConclusionA questionnaire including breast‐specific questions provides important information on final cosmetic results and satisfaction after BCT. These outcomes can also be of great value as quality indicators and pre‐operative counseling. The major influence of breast‐specific factors on asymmetry underlines the importance of achieving an optimal excision volume at the initial procedure.
A novel ultra high‐performance liquid chromatography‐tandem mass spectrometry method for the simultaneous determination of xanthones and steroidal saponins in crude and salt‐processed Anemarrhenae Rhizoma aqueous extracts
Authors: Ji De , Su Xiaonan , Huang Ziyan , Wang Qiaohan , Lu Tulin 
Published: February 2018

AbstractWe established a rapid and sensitive ultra high‐performance liquid chromatography tandem mass spectrometry method for the simultaneous quantification of xanthones and steroidal saponins in rat plasma. Chromatographic separation was achieved on a C18 column with a mobile phase comprising acetonitrile and 0.1% formic acid. The detection was performed by negative electrospray ionization in multiple reaction monitoring mode. The validated method showed good linearity within the tested range (r > 0.9945). The intra‐ and interday precision at high, medium, and low concentrations was less than 7.96%. The bias of accuracies ranged from −1.92 to 9.62%. The extraction recoveries of the compounds ranged from 84.78 to 88.69%, and the matrix effects ranged from 96.76 to 108.59%. This method was successfully applied to a pharmacokinetic comparison of crude and salt‐processed Anemarrhenae Rhizoma aqueous extracts after oral administration in rats. The maximum plasma concentration and area under concentration–time curve of timosaponin BIII and timosaponin AIII increased significantly (P < 0.05 or 0.01) and those of timosaponin BII decreased significantly (P < 0.05) after processing. These results could contribute to the clinical application of crude and salt‐processed Anemarrhenae Rhizoma and reveal the processing mechanism.
Method for the simultaneous determination of monoaromatic and polycyclic aromatic hydrocarbons in industrial effluents using dispersive liquid–liquid microextraction with gas chromatography–mass spectrometry
Authors: Makoś Patrycja , Fernandes André , Boczkaj Grzegorz 
Published: February 2018

AbstractWe present a new method for simultaneous determination of 22 monoaromatic and polycyclic aromatic hydrocarbons in postoxidative effluents from the production of petroleum bitumen using dispersive liquid–liquid microextraction coupled to gas chromatography and mass spectrometry. The eight extraction parameters including the type and volume of extraction and disperser solvent, pH, salting out effect, extraction, and centrifugation time were optimized. The low detection limit ranging from 0.36 to 28 μg/L, limit of quantitation (1.1–84 μg/L), good reproducibility, and wide linear ranges, as well as the recoveries ranging from 71.74 to 114.67% revealed that the new method allows the determination of aromatic hydrocarbons at low concentration levels in industrial effluents having a very complex composition. The developed method was applied to the determination of content of mono‐ and polycyclic aromatic hydrocarbons in samples of raw postoxidative effluents in which 15 compounds were identified at concentrations ranging from 1.21 to 1017.0 μg/L as well as in effluents after chemical treatment.
How chemists use the literature
Authors: Williams Ivor A. 
Published: February 2018

ABSTRACTIn the light of current developments in information technology, coupled with the pressure on library budgets and the increasing interest in document delivery systems as a alternative to purchasing journals (“just in time instead of just in case”�) this paper considers the need for some quantitative information as to how researchers in chemistry currently meet their needs for access to material of interest to them.
Engineered headwaters can act as sources of dissolved organic matter and nitrogen to urban stream networks
Authors: Fork Megan L. , Blaszczak Joanna R. , Delesantro Joseph M. , Heffernan James B. 
Published: February 2018

AbstractImproved management of urban stream water quality requires identification of sources contributing excess nutrients and organic matter. While soils and lawns are potential nonpoint sources characterized by large pools of carbon (C) and nitrogen (N), their hydrologic connectivity to streams is often low relative to impervious surfaces. In contrast, engineered headwaters (gutters and pipes) retain smaller pools of C and N, but efficiently process litter into dissolved organic matter and are highly connected to streams during storms. We found that engineered headwaters have the potential to provide more than enough dissolved C and N to account for streamflow fluxes during storms. This finding suggests that engineered headwaters can act not only as stormwater conveyances, but as important proximate sources of dissolved carbon and nutrients to streams during storms. A nested mass balance approach like the one used here can further understanding of the contributions of previously overlooked subsystems, such as engineered headwaters, to biogeochemistry and element flux in urban catchments.
Hybrid‐State Dynamics of Dye Molecules and Surface Plasmon Polaritons under Ultrastrong Coupling Regime
Authors: Wang Hai , Wang Hai‐Yu , Chen Qi‐Dai , Xu Huai‐Liang , Sun Hong‐Bo , Huang Fangcheng , Raja Waseem , Toma Andrea , Proietti Zaccaria Remo 
Published: February 2018

AbstractThe achievement of an ultrastrong coupling regime between surface plasmon modes generated by gold conical pits arrays and excitons associated to squaraine dye is demonstrated. Numerical and experimental steady‐state reflection measurements demonstrate a remarkable Rabi splitting of 860 meV, to date the largest reported value involving surface plasmon modes. Furthermore, the dynamics of the hybrid states under the ultrastrong coupling regime is investigated by transient absorption spectroscopy. The results show that the upper bands are too short‐lived to be detected, while the lower bands have a relatively shorter lifetime with respect to the bleaching recovery of pure squaraine dye. This result contradicts the behaviour of systems in strong coupling regimes, suggesting a different photophysics between strong and ultrastrong coupled systems.
Comparison between 8‐methoxypsoralen and 5‐aminolevulinic acid in killing T cells of photopheresis patients ex vivo
Authors: Holien Toril , Gederaas Odrun Arna , Darvekar Sagar Ramesh , Christensen Eidi , Peng Qian 
Published: February 2018

Background and ObjectiveExtracorporeal photopheresis (ECP), an established modality for cutaneous T‐cell lymphoma (CTCL) and graft‐versus‐host disease, involves ex vivo treatment of isolated leukocytes of a patient with the photosensitizing drug 8‐methoxypsoralen (8‐MOP) and ultraviolet‐A (UV‐A) exposure before reinfusion back to the patient. However, 8‐MOP binds to both diseased and normal cells and thus kills both types of the cells after UV‐A illumination with little selectivity. Clinically, this modality gives only partial response in the majority of treated patients. 5‐Aminolevulinic acid (5‐ALA), a precursor of the potent photosensitizer protoporphyrin IX (PpIX), has been shown to selectively induce PpIX in activated T lymphocytes (T cells) and could be an alternative for 8‐MOP. The objectives of this study were to investigate ex vivo 5‐ALA dark toxicity, 5‐ALA‐induced PpIX production, and photodynamic effect on T cells obtained from clinical ECP patients after the treatment of 5‐ALA or 8‐MOP plus a built‐in certified UV‐A source in the commercial Therakos™ Photopheresis System.Materials and MethodsFlow cytometry was used to study dark cytotoxic effects of 5‐ALA on human leukocytes, to measure the production of 5‐ALA‐induced PpIX in CD25+ activated T cells from both diluted mononuclear cells and undiluted buffy coat samples of ECP patients and to compare photodynamic effects on CD4+ and CD8+ T cells with 5‐ALA/UV‐A or 8‐MOP/UV‐A.ResultsNo dark toxicity of 5‐ALA on the leukocytes of ECP patients was seen at concentrations up to 10 mM for an incubation of up to 20 hours. 5‐ALA‐induced PpIX was produced more in CD25+ activated T cells than resting T cells in both diluted mononuclear cells and undiluted buffy coat samples, although there was a huge variation of samples from different individual patients. The CD4+ and CD8+ T cells treated with 5‐ALA/UV‐A were killed more than those treated with 8‐MOP/UV‐A.ConclusionThese results suggest that 5‐ALA/UV‐A may have the potential for improving the efficacy of ECP. Lasers Surg. Med. 50:469–475, 2018. © 2018 Wiley Periodicals, Inc.
Cheminformatics Analysis of Dynamic WNK‐Inhibitor Interactions
Authors: Kuenemann Melaine A. , Fourches Denis 
Published: February 2018

AbstractThe With‐No‐Lysine (WNK) serine/threonine kinase family constitutes a unique and distinctive branch of the kinome. The four proteins of this family (WNK1/2/3/4) are involved in blood pressure regulation, body fluid, and electrolyte homeostasis. Herein, we modeled and analyzed the binding modes of all publicly‐available small orthosteric and allosteric binders (including WNK463 and WNK467) experimentally tested towards any of the WNK family member. To do so, we relied on state‐of‐the‐art cheminformatics approaches including structure‐based molecular docking and molecular dynamics simulations. In particular, we computed and analyzed the (i) molecular selectivity of known inhibitors when docked in the binding site of each WNK family member, (ii) the dynamic WNK‐inhibitor interactions at both orthosteric and allosteric sites to derive new structure‐activity relationships, and (iii) the key specific interactions present in each binding site. This study reports on the first, cheminformatics‐powered analysis of the entire chemical space of known WNK inhibitors. We discuss the conservation of critical WNK‐inhibitor interactions and the existence of isoform‐specific interactions that could enable the rational design of more potent and selective WNK binders.
Measuring Socioeconomic Status and Environmental Factors in the SAYCARE Study in South America: Reliability of the Methods
Authors: De Moraes Augusto Cesar Ferreira , Forkert Elsie C.O. , Vilanova‐Campelo Regina Célia , González‐Zapata Laura Inés , Azzaretti Leticia , Iguacel Isabel , Huicho Luis , Moliterno Paula , Moreno Luis Alberto , Carvalho Heráclito Barbosa 
Published: February 2018

ObjectiveThis paper aimed to test the reliability of two questionnaires in studies involving children and adolescents (aged 3‐18 years) in seven South American cities. One assesses socioeconomic status (SES) and the other measures environmental factors.MethodsThe SES questionnaire was composed of 14 questions, which included the presence of several consumer goods, domestic services, family income, parental education level, and current parental occupation status. The environmental questionnaire was composed of 15 questions to measure the social and infrastructure characteristics of the area of residence. Parents or guardians completed the questionnaires on behalf of their children. Adolescents answered the questions themselves for environmental factors, while those related to SES factors were answered by their parents or guardians. We analyzed the reliability of the questionnaires through kappa coefficient determination. Multilevel linear regression models were applied to calculate the correlation between the total household scores, the household income, and parents' education level.ResultsThe environmental questionnaire showed good reproducibility in both age groups (k = 0.132‐0.612 in children and k = 0.392‐0.746 in adolescents). The SES questionnaire showed strong reliability in both age groups for all indicators (k = 0.52‐1.00 in children and k = 0.296‐0.964 in adolescents).ConclusionsOur multiple indicator questionnaires focused on environmental factors and SES in pediatric health surveys provided useful and easily applicable additional indicators to measure these important determinants of cardiovascular health.
Is the Measurement of Blood Pressure by Automatic Monitor in the South American Pediatric Population Accurate? SAYCARE Study
Authors: Araújo‐Moura Keisyanne , De Moraes Augusto César Ferreira , Forkert Elsie C.O. , Berg Gabriela , Cucato Gabriel Grizzo , Forjaz Claúdia Lucia de Moraes , Moliterno Paula , Gaitan‐Charry Diego , Delgado Carlos A. , González‐Gil Esther M. , Moreno Luis Alberto , Carvalho Heráclito Barbosa , Torres‐Leal Francisco Leonardo 
Published: February 2018

ObjectiveThis study aimed to test the validity of an automatic oscillometric device to measure the blood pressure (BP) in children (n = 191) and adolescents (n = 127) aged 3 to 18 years.MethodsSystolic BP (SBP) and diastolic BP (DBP) levels were measured simultaneous by automatic device and mercury column with Y‐connection. To verify the validity, Bland‐Altman plots and limits of agreement of 95% (95% LOA), specificity and sensitivity of the device, and the grade of British Hypertension Society (BHS) criteria were used.ResultsThe monitor measurements demonstrated lower measurement bias (mean difference [95% LOA]): 1.4 (−9.9 to 12.8) mmHg in children and 4.3 (−7.8 to 16.5) mmHg in adolescents for SBP. For DBP, it was 2.2 (−7.4 to 11.7) mmHg in children and 1.4 (−8.4 to 11.1) mmHg in adolescents. The sensitivity in children was 21.4 (95% CI = 16.3‐26.6), and in adolescents, it was 20.0 (95% CI = 13.2‐26.8); the specificity was 95.9 (95% CI = 93.4‐98.4) in children and 100.0 (95% CI = 100.0‐100.0) in adolescents. The monitor‐tested ratings are Grade B for SBP in children and SBP and DBP in adolescents and Grade C for DBP in children.ConclusionsThe automatic monitor presented high values of specificity and lower values of sensitivity to the diagnosis of HBP; however, it can be considered accurate (lower measurement bias) and valid for epidemiological and clinical practice in accordance with BHS criteria.
A comparison of pseudoproline substitution effects on cyclisation yield in the total syntheses of segetalins B and G
Authors: Wong Michelle S. Y. , Jolliffe Katrina A. 
Published: February 2018

AbstractThe total syntheses of the naturally occurring cyclic pentapeptides, segetalins B and G, using a traceless pseudoproline‐mediated cyclization reaction is reported. The incorporation of a cysteine‐derived gem‐dimethyl pseudoproline [Cys(ΨMe,MePro)] residue in the linear precursors to induce a cisoid amide bond prior to the head‐to‐tail cyclization resulted in improved cyclization yields in both cases. Cysteine‐derived pseudoproline residues lacking the gem‐dimethyl substituents [Cys(ΨH,HPro)] were not as effective at inducing cisoid conformations of the amide bonds and resulted in lower cyclization yields with a concomitant increase in the formation of cyclodimers. The Cys(ΨMe,MePro) containing cyclic peptides were subject to deprotection and desulfurization to give the alanine containing natural products in high overall yields. In contrast, deprotection of cyclic peptides containing Cys(ΨH,HPro) residues upon treatment with trifluoroacetic acid removed other side chain‐protecting groups but left the Cys(ΨH,HPro) residues intact.
Partially bio‐based aromatic polyimides derived from 2,5‐furandicarboxylic acid with high thermal and mechanical properties
Authors: Ma Kai , Chen Guofei , Wang Wei , Zhang Anjiang , Zhong Yingying , Zhang Yajie , Fang Xingzhong 
Published: February 2018

ABSTRACTTwo novel bio‐based diamines are synthesized through introduction of renewable 2,5‐furandicarboxylic acid (2,5‐FDCA), and the corresponding aromatic polyimides (PIs) are then prepared by these diamines with commercially available aromatic dianhydrides via two‐step polycondensation. The partially bio‐based PIs possess high glass transition temperatures (Tgs) in the range from 266 to 364 °C, high thermal stability of 5% weight loss temperatures (T5%s) over 420 °C in nitrogen and outstanding mechanical properties with tensile strengths of 79–138 MPa, tensile moduli of 2.5–5.4 GPa, and elongations at break of 3.0–12.3%. Some colorless PI films (PI‐1‐b and PI‐1‐c) with the transmittances at 450 nm over 85% are prepared. The overall properties of 2,5‐FDCA‐based PIs are comparable with petroleum‐based PI derived from isophthalic acid, displaying the potential for development of innovative bio‐based materials. © 2018 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2018, 56, 1058–1066
3D Flake‐Like Bi2Te3 with Outstanding Lightweight Electromagnetic Wave Absorption Feature
Authors: Chen Jiabin , Liang Xiaohui , Quan Bin , Yang Zhihong , Du Youwei , Ji Guangbin 
Published: February 2018

AbstractFlake‐like semiconductors with strong interfacial polarization exhibit excellent electromagnetic absorption properties. To the best of the knowledge, 3D flake‐like Bi2Te3 is never reported as effective MAMs (microwave absorption materials). Herein, it is first introduced the novel lightweight microwave absorption of 3D flake‐like Bi2Te3 synthesized by a simple hydrothermal process. Compared with the traditional research objects, the obtained Bi2Te3 possessed prominent absorbing ability at a rather thin thickness (1.0 mm), which will draw much attention to new‐materials for electromagnetic wave absorption.
Dietary tetrahydrocurcumin reduces renal fibrosis and cardiac hypertrophy in 5/6 nephrectomized rats
Authors: Lau Wei Ling , Khazaeli Mahyar , Savoj Javad , Manekia Kasim , Bangash Maria , Thakurta Roshni G. , Dang Anhthu , Vaziri Nosratola D. , Singh Bhupinder 
Published: February 2018

AbstractTetrahydrocurcumin (THC) is the principal metabolite of curcumin and has antioxidant properties. In the present investigation, the effect of THC on renal and cardiovascular outcomes was studied in rats with chronic kidney disease (CKD). CKD rats were randomized following 5/6 nephrectomy to a special diet for 9 weeks which contained 1% THC (CKD+THC group). Low‐dose polyenylphosphatidylcholine was used as a lipid carrier to increase bioavailability. Endpoints included tail blood pressure, normalized heart weight, plasma and urine biochemical data, and kidney tissue analyses. CKD animals demonstrated increased proteinuria, decreased creatinine clearance, hypertension, and cardiac hypertrophy. The antioxidant proteins CuZn SOD and glutathione peroxidase were decreased in the remnant kidney, while apoptosis (caspase‐3) and fibrosis (alpha‐SM actin) were increased. Renal fibrosis was confirmed histologically on trichrome staining. These pathologic changes were ameliorated in the CKD+THC group with significant decrease in proteinuria, hypertension, and kidney fibrosis. THC therapy restored levels of CuZn SOD and glutathione peroxidase. Consistent with prior reports, dietary THC did not improve nuclear Nrf2 levels. In summary, dietary THC therapy improved expression of antioxidant proteins in the remnant kidney, decreased renal fibrosis and proteinuria, and ameliorated hypertension in 5/6 nephrectomized rats.
Moving on? Gender, education, and citizenship as key factors among short‐term onward migration planners
Authors: Ortensi Livia Elisa , Barbiano di Belgiojoso Elisa 
Published: February 2018

AbstractOnward migration is a rising issue in migration studies as a consequence of the growing complexity in migration patterns worldwide. This paper analyses historic and economic reasons behind the recent surge of onward migration from Southern European countries and, more specifically, Italy. Using 2014 ORIM data about short‐term onward migration intentions and a logistic regression model, the paper explores factors that select aspirant onward migrants from Italy. The model tests the effects of socio‐demographic and economic factors. The results of the study question the idea of citizenship as the highest level of integration in the host country and suggest that the recent wave of onward migration from Italy is mainly a reactive phenomenon triggered by the economic crisis. Most of all, this study explicitly underlines the role of gender in shaping intentions of short‐term onward migration in Italy. The gender‐sensible approach adopted in the present study shows the important role of women in the decision‐making process of couples: female unemployment significantly increases intentions of onward migration, and the migration is also considered as an opportunity for the spouse and a gain in the economic prospects of the entire family. Conversely, female employment has a significant role in preventing onward migration.
EWMA chart based on Bayes‐conditional pivotal quantity for Weibull percentiles under complete data and type‐II censoring
Authors: Wang Fu‐Kwun , Bizuneh Berihun , Cheng Xiao‐Bin 
Published: February 2018

AbstractBayes‐conditional control chart has been used for monitoring the Weibull percentiles with complete data and type‐II censoring. Firstly, the Weibull data are transformed to the smallest extreme value (SEV) distribution. Secondly, the posterior median of quantiles is used as a monitoring statistic. Finally, a pivotal quantity based on the monitoring statistic with its conditional distribution function is derived for obtaining the control limits. This control chart is denoted as Shewhart‐SEV‐
. In this study, we extend this work based on an exponential weighted moving average model named exponential weighted moving average‐SEV‐
for monitoring the Weibull percentiles. We provide the statistical properties of the monitoring statistic. The average run length and the standard deviation of run lengths, computed by the integral equation approach, are used as performance measures. The results indicate that the proposed chart performs better than the Shewhart‐SEV‐
. The breaking strength of carbon fibers is used to illustrate the application of the proposed control chart.