bluuebunny/crossref_metadata_2025_split huggingface dataset:
Satisfaction With Services Among Attendees of Physiotherapy Outpatient Clinics in Tertiary Hospitals in Lagos State
Authors: Odumodu Ijeoma Jane , Olufunlayo Tolulope Florence , Ogunnowo Babatunde Enitan , Kalu Michael Ebe 
Published: May 2019

Aim: To determine outpatients’ satisfaction with physiotherapy services in tertiary hospitals in Lagos State, Nigeria. Method: This cross-sectional study utilized a simple random sampling method to recruit 284 participants. Participants responded to a 2-part structured questionnaire with 33-items on a 5-point Likert-type scale. Participants were asked questions about their satisfaction with physiotherapy services, staff attitudes, and the accessibility of outpatient physiotherapy clinics. Data were analyzed using descriptive analysis and χ2. Results: About 28.8% of the participants were satisfied or very satisfied with the location of the outpatient physiotherapy clinics. The majority of the participants were satisfied or very satisfied with these physiotherapy services in maintaining privacy (86.2%), scheduling convenient clinic appointments (78.2%), prompt scheduling of the first physiotherapy clinic appointment (74.6%) and subsequent visits (78.9%), and providing a calm/relaxing atmosphere (90.1%). While 22.5% of the participants were satisfied or very satisfied with the waiting time in these physiotherapy clinics, 86.3% and 97.9% were satisfied or very satisfied with staff attitudes and the cost of the therapy, respectively. Almost all (97.9%) the participants reported being satisfied or very satisfied with their overall experience in the physiotherapy clinics. While there was an association between marital and educational status with overall satisfaction scores, age and gender showed no association. Conclusion: Our findings suggest that patients attending the outpatient physiotherapy clinics in tertiary hospitals in Lagos State, Nigeria, were satisfied or very satisfied with the domain that measured overall satisfaction. Strategies to reduce the waiting time in these physiotherapy clinics and to enhance physical accessibility of the physiotherapy clinics are encouraged.
Impact of combining indoor residual spraying and long-lasting insecticidal nets on Anopheles arabiensis in Ethiopia: results from a cluster randomized controlled trial
Authors: Kenea Oljira , Balkew Meshesha , Tekie Habte , Deressa Wakgari , Loha Eskindir , Lindtjørn Bernt , Overgaard Hans J. 
Published: May 2019

Abstract
Background
Indoor residual house spraying (IRS) and long-lasting insecticidal nets (LLINs) are the key front-line malaria vector interventions against Anopheles arabiensis, the sole primary malaria vector in Ethiopia. Universal coverage of both interventions has been promoted and there is a growing demand in combinations of interventions for malaria control and elimination. This study compared the impact on entomological outcomes of combining IRS and LLINs with either intervention alone in Adami Tullu district, south-central Ethiopia. The epidemiological outcomes were recently published on a separate paper.

Methods
This factorial, cluster-randomized, controlled trial randomized villages to four study arms: IRS + LLIN, IRS, LLIN, and control. LLINs (PermaNet 2.0) were provided free of charge. IRS with propoxur was applied before the main malaria transmission season in 2014, 2015 and 2016. Adult mosquitoes were collected in randomly selected villages in each arm using CDC light trap catch (LTC) set close to a sleeping person, pyrethrum spray catch (PSC), and artificial pit shelter (PIT), for measuring mosquito host-seeking density (HSD), indoor resting density (IRD), and outdoor resting density (ORD), respectively. Human landing catch (HLC) was performed in a sub-set of villages to monitor An. arabiensis human biting rates (HBR). Mean vector densities and HBR were compared among study arms using incidence rate ratio (IRR) calculated by negative binomial regression.

Results
There were no significant differences in mean densities (HSD, IRD, ORD) and HBR of An. arabiensis between the IRS + LLIN arm and the IRS arm (p > 0.05). However, mean HSD, IRD, ORD, and HBR were significantly lower in the IRS + LLIN arm than in the LLIN alone arm (p < 0.05). All An. arabiensis tested for malaria infection were negative for Plasmodium species. For this reason, the entomological inoculation rate could not be determined.

Conclusions
The IRS + LLIN were as effective as IRS alone in reducing densities and HBR of An. arabiensis. However, the effectiveness of the two interventions combined was higher than LLINs alone in reducing densities and HBR of the vector. Added impact of the combination intervention against malaria infectivity rates of An. arabiensis compared to either intervention alone remains unknown and warrants further research.
Trial registration PACTR201411000882128. Registered 8 September 2014, https://trialsjournal.biomedcentral.com/articles/10.1186/s13063-016-1154-2
Tree regeneration following wildfires in the western US: a review
Authors: Stevens-Rumann Camille S. , Morgan Penelope 
Published: May 2019

AbstractBackgroundWildfires, like many disturbances, can be catalysts for ecosystem change. Given projected climate change, tree regeneration declines and ecosystem shifts following severe wildfires are predicted. We reviewed scientific literature on post-fire tree regeneration to understand where and why no or few trees established. We wished to distinguish sites that won’t regenerate to trees because of changing climate from sites where trees could grow post fire if they had a seed source or were planted, thus supporting forest ecosystem services for society and nature, such as timber supply, habitat, watershed protection, and carbon storage.ResultsOur literature review showed that little to no post-fire tree regeneration was more common in low-elevation, dry forest types than in high-elevation forest types. However, depending on the region and species, low tree regeneration was also observed in high elevation, moist forests. Regeneration densities varied by species and seedling densities were attributed to distances to a seed source, water stress or precipitation, elevation, slope, aspect, and plant competition. Our findings provide land managers with two primary considerations to offset low tree regeneration densities. First, we supply a decision support tool of where to plant tree seedling in large high severity burned patches. Second, we recommend possibilities for mitigating and limiting large high severity burned patches to increase survival of trees to be sources of seed for natural regeneration.ConclusionsFew or no tree seedlings are establishing on some areas of the 150+ forest fires sampled across western US, suggesting that forests may be replaced by shrublands and grasslands, especially where few seed source trees survived the wildfires. Key information gaps on how species will respond to continued climate change, repeated disturbances, and other site factors following wildfires currently limit our ability to determine future trends in forest regeneration. We provide a decision tree to assist managers in prioritizing post-fire reforestation. We emphasize prioritizing the interior of large burned patches and considering current and future climate in deciding what, when, and where to plant trees. Finally, managing fires and forests for more seed-source tree survival will reduce large, non-forested areas following wildfires where post-fire management may be necessary.
The therapeutic needs of psychiatric in-patients with psychosis: A qualitative exploration of patient and staff perspectives
Authors: Wood Lisa , Williams Claire , Billings Jo , Johnson Sonia 
Published: May 2019

Background
Concerns are recurrently expressed that the therapeutic content of in-patient care is limited and lacking clear guidance. The perspectives of patients and staff regarding therapeutic priorities for psychiatric in-patient care have been little explored and compared.

Aims
The aim of this study was to examine patient and staff perspectives on the care priorities of psychiatric in-patients with psychosis.

Method
We recruited 12 in-patients with psychosis and 12 multidisciplinary team staff. All participants undertook a semi-structured interview examining their perspectives on the therapeutic needs of people with psychosis during admission. Interviews were transcribed verbatim and thematic analysis conducted.

Results
Three superordinate themes arose from patient interviews: ‘the importance of considering social circumstances and trauma’, ‘managing the intra- and interpersonal impact of psychosis’ and ‘lack of control and collaboration in care’ and three from staff interviews: ‘multidisciplinary facilitators of care’, ‘treating complexity and incorporating social factors’ and ‘restrictive practices preventing quality care provision’. Comparison of patient and staff themes identified unmet needs in addressing social marginalisation, trauma and distress, and the importance of collaborative treatment process and inclusion of spirituality.

Conclusions
There are gaps between staff and patient perspectives on important priorities for in-patient care that may help explain persistent patient dissatisfaction with in-patient care. Findings suggest the need for coproduced work to develop and test interventions that address broader therapeutic priorities.

Declaration of interest
None.
Aldosterone Stimulates Its Biosynthesis Via a Novel GPER-Mediated Mechanism
Authors: Caroccia Brasilina , Seccia Teresa Maria , Piazza Maria , Prisco Selene , Zanin Sofia , Iacobone Maurizio , Lenzini Livia , Pallafacchina Giorgia , Domening Oliver , Poglitsch Marko , Rizzuto Rosario , Rossi Gian Paolo 
Published: May 2019

Abstract

Context
The G protein–coupled estrogen receptor (GPER) mediates an aldosterone secretagogue effect of 17β-estradiol in human HAC15 adrenocortical cells after estrogen receptor β blockade. Because GPER mediates mineralocorticoid receptor-independent aldosterone effects in other cell types, we hypothesized that aldosterone could modulate its own synthesis via GPER activation.

Methods
HAC15 cells were exposed to aldosterone in the presence or absence of canrenone, a mineralocorticoid receptor antagonist, and/or of the selective GPER antagonist G36. Aldosterone synthase (CYP11B2) mRNA and protein levels changes were the study end points. Similar experiments were repeated in strips obtained ex vivo from aldosterone-producing adenoma (APA) and in GPER-silenced HAC15 cells.

Results
Aldosterone markedly increased CYP11B2 mRNA and protein expression (vs untreated samples, P < 0.001) in both models by acting via GPER, because these effects were abolished by G36 (P < 0.01) and not by canrenone. GPER-silencing (P < 0.01) abolished the aldosterone-induced increase of CYP11B2, thus proving that aldosterone acts via GPER to augment the step-limiting mitochondrial enzyme (CYP11B2) of its synthesis. Angiotensin II potentiated the GPER-mediated effect of aldosterone on CYP11B2. Coimmunoprecipitation studies provided evidence for GPER-angiotensin type-1 receptor heterodimerization.

Conclusion
We propose that this autocrine-paracrine mechanism could enhance aldosterone biosynthesis under conditions of immediate physiological need in which the renin-angiotensin-aldosterone system is stimulated as, for example, hypovolemia. Moreover, as APA overexpresses GPER this mechanism could contribute to the aldosterone excess that occurs in primary aldosteronism in a seemingly autonomous fashion from angiotensin II.
Violence, Democracy, and the Major-Minor Question
Authors: Chaturvedi Ruchi 
Published: May 2019

Abstract
This essay revolves around different types of violence witnessed in political society and their relationship to the democratic form that many postcolonial states have inherited. It especially draws on studies of popular protests, negrophobic and xenophobic violence against lower-income migrants, and deadly competition for elected party and government positions in postapartheid South Africa. The discussion focuses on describing the relationship between these three phenomena alongside aspects of multiparty politics, single-party rule, and violent contests for profitable offices in other African states. The continuous competition to defeat opponents, obtain victories, secure majorities, occupy the place of power, and embody its force—which liberal democracies institute—is central to this argument about the violence that South Africa has witnessed in recent times. The essay unpacks these ways of doing politics in order to make a broader theoretical statement about how received models of democracy are implicated in political society's violence in postcolonial contexts.
Beyond the whole-mount phenotype: high-resolution imaging in fluorescence-based applications on zebrafish
Authors: Oralová Veronika , Rosa Joana T. , Soenens Mieke , Bek Jan Willem , Willaert Andy , Witten Paul Eckhard , Huysseune Ann 
Published: May 2019

ABSTRACTZebrafish is now widely used in biomedical research as a model for human diseases, but the relevance of the model depends on a rigorous analysis of the phenotypes obtained. Many zebrafish disease models, experimental techniques and manipulations take advantage of fluorescent reporter molecules. However, phenotypic analysis often does not go beyond establishing overall distribution patterns of the fluorophore in whole-mount embryos or using vibratome or paraffin sections with poor preservation of tissue architecture and limited resolution. Obtaining high-resolution data of fluorescent signals at the cellular level from internal structures mostly depends on the availability of expensive imaging technology. Here, we propose a new and easily applicable protocol for embedding and sectioning of zebrafish embryos using in-house prepared glycol methacrylate (GMA) plastic that is suited for preservation of fluorescent signals (including photoactivatable fluorophores) without the need for antibodies. Four main approaches are described, all involving imaging fluorescent signals on semithin (3 µm or less) sections. These include sectioning transgenic animals, whole-mount immunostained embryos, cell tracking, as well as on-section enzyme histochemistry.
Thomas M. Jessell (1951-2019)
Authors: Arber Silvia , Briscoe James 
Published: May 2019

ABSTRACT
Thomas M. Jessell died on April 28, 2019. Tom revolutionized our understanding of the mechanisms through which neuronal cell type identities are programmed during development to dictate their function in the adult nervous system. Here, we (two former postdocs from his lab) remember some of his most important scientific contributions and how these changed the way we now understand and think about neuronal circuits controlling movement.
Ethics, Bounded Rationality, and IP Sharing in IT Outsourcing
Authors: Anand Krishnan S. , Goyal Manu 
Published: May 2019

Our dynamic model of information technology (IT) outsourcing integrates incomplete contracts, moral hazard, and adverse selection under both perfect and, more realistically, bounded rationality. In addition to the classical profit-maximizing firm unconstrained by ethics, we model an ethically constrained (but otherwise profit-maximizing) firm that honors its contractual obligations irrespective of legal restraints. We prove that under bounded rationality, the ethically constrained firm can obtain strictly greater profits than the unconstrained profit-maximizing firm, even when (i) the unconstrained firm has access to a superset of the ethical firm’s strategies and (ii) the ethical firm is unable to reveal its ethical commitment to its contracting partner anytime during the contractual relationship. Thus, a commitment to ethics, while of course being morally desirable, can lead to higher profits than the unbridled profit-maximization of classical economics. We also prove that ethics is foundational to both intellectual property (IP) sharing and reputation effects, two well-known facilitators of IT outsourcing. In fact, the mere possibility of ethical firms (a) forces across-the-board IP sharing even if it lowers profits and (b) induces even an ethically unconstrained firm to invest in developing a reputation for ethics. Our model provides a novel explanation, rooted in ethics, for why IT outsourcing is booming despite the formidable impediments of incomplete contracts, moral hazard, and adverse selection. This paper was accepted by Anandhi Bharadwaj, information systems.
The Red, the Black, and the Plastic: Paying Down Credit Card Debt for Hotels, Not Sofas
Authors: Quispe-Torreblanca Edika G. , Stewart Neil , Gathergood John , Loewenstein George 
Published: May 2019

Using transaction data from a sample of 1.8 million credit card accounts, we provide the first field test of a major prediction of Prelec and Loewenstein’s theory of mental accounting: that consumers will pay off expenditure on transient forms of consumption more quickly than expenditure on durables. According to the theory, this is because the pain of paying can be offset by the future anticipated pleasure of consumption only when money is spent on consumption that endures over time. Consistent with this prediction, we found that repayment of debt incurred for nondurable goods is an absolute 10% more likely than repayment of debt incurred for durable goods. The strength of this relationship is comparable to an increment in 15 percentage points in the credit card annualized percentage rate. Our results have not only managerial implications for the structuring of financial transactions (e.g., that credit card customers should be given the option of paying off specific purchases) but also more general implications for exploiting variations in the pain of paying in incentive schemes aimed at customers and employees. This paper was accepted by Yan Chen, behavioral economics.
The Subject of Wrongs: Crime, Populism, and Venezuela’s Punitive Turn
Authors: Samet Robert 
Published: May 2019

This article draws on research in Venezuela to make a broader argument about the link between populism and injury. Specifically, it considers the role that crime victimhood plays in the rise of punitive populism or the so-called punitive turn. Under President Hugo Chávez, the Venezuelan government publicly denounced tough-on-crime policies as instruments of socioeconomic oppression. Following Chávez’s death, there was an abrupt change of course due, in part, to the opposition’s mobilization of crime victims. The Venezuelan case illustrates a double bind that confronts scholars who are critical of the punitive turn. On the one hand, the figure of the crime victim mediates the body politic in a way that reproduces structures of racial and economic domination. On the other hand, the failure to substantively address the material injuries of crime victims propels grassroots support for punitive populism. Instead of focusing on the subject of rights, this article proposes starting with the subject of wrongs as a bottom-up approach to political subjectivity that can help us understand the dynamic behind punitive populism and show us a way out of the double bind.
Abstracto
Este artículo se basa en trabajo de campo en Venezuela y persigue establecer un argumento general sobre el vínculo entre el populismo y el daño. Específicamente, el artículo considera el papel que las víctimas del crimen desempeñan en el auge del populismo punitivo o el giro punitivo. Durante el gobierno de Hugo Chávez se denunciaba la política de mano dura como un instrumento de opresión socioeconómica. Tras la muerte de Chávez, hubo un cambio abrupto en esta práctica debido, en parte, a la movilización de las víctimas del crimen. El caso venezolano constituye un dilema para los académicos que critican el giro punitivo. Por un lado, la figura de la víctima participa en el cuerpo político de una manera que reproduce estructuras de dominación racial y económica. Por otro lado, la incapacidad para responder efectivamente a los reales daños del crimen aumenta el apoyo popular a la política de mano dura. En vez de enfocarse en el tema de los derechos, este artículo propone enfocarse en el tema de los males (o daños) como una manera de abordar la subjetividad política que podría, por un lado ayudarnos a entender la dinámica detrás del populismo punitivo, y por el otro encontrar una solución al dilema que este plantea.
Novel heterozygous NFKB1 mutation in a pediatric patient with cytopenias, splenomegaly, and lymphadenopathy
Authors: Duan Lucy , Feanny Stephen 
Published: May 2019

Background: The nuclear factor κ-light-chain enhancer of activated B cells (NF-κB) signaling pathway is a critical regulator of many important adaptive and innate immune responses. The NF-κB transcription factor family consists of 5 structurally related core proteins, one of which is NFKB1. Mutations in the NFKB1 gene has been reported in patients with common variable immune deficiency (CVID) as well as with a large spectrum of clinical features including recurrent viral, bacterial, and fungal infections, autoimmunity, inflammation, and malignancy. Aim: We describe the clinical characteristics of a pediatric patient with a novel mutation in NFKB1. Methods: Patient informed consent was obtained in accordance with approved protocols from the Research Ethics Board at the Hospital for Sick Children. Gene panel testing was employed to identify the immune aberration. Results: Our patient, a previously well 18-month-old boy of Philippines descent, presented with multi-lineage cytopenias (thrombocytopenia, hemolytic anemia, neutropenia), splenomegaly, and lymphadenopathy. He did not have prior history of recurrent infections. Immunological work-up showed normal numbers of T and B cells, normal quantitative immunoglobulins, and adequate vaccination titres. Gene panel testing revealed a novel heterozygous missense variant c.425T>C (p. Ile142Thr) in the NFKB1 gene. Due to persistent cytopenias unresponsive to steroids and IVIG, he was started on Sirolimus with improvement in symptoms. Conclusion: NFKB1 encodes for p105, which is processed to generate the active p50 transcription factor that can interact with different proteins to activate or inhibit downstream signaling. Our patient was found to have a missense mutation in the Rel homology domain (RHD) of p50, which has distinct functions including DNA binding, protein dimerization, and inhibitory protein binding. The clinical presentation described here broadens the scope of characteristics associated with heterozygous NFKB1 mutations. Statement of novelty: We report a novel heterozygous missense variant c.425T>C (p. Ile142Thr) in the NFKB1 gene in a pediatric patient with cytopenias, lymphadenopathy, and splenomegaly. To the best of our knowledge, this variant has not been previously reported.