bluuebunny/crossref_metadata_2025_split huggingface dataset:
Rank 4 stable vector bundles on hyperk\"ahler fourfolds of Kummer type
Authors: O'Grady Kieran G. 
Published: December 2024

We partially extend to hyperk\&quot;ahler fourfolds of Kummer type the results that we have proved regarding stable rigid vector bundles on hyperk\&quot;ahler (HK) varieties of type $K3^{[n]}$. Let $(M,h)$ be a general polarized HK fourfold of Kummer type such that $q_M(h)\equiv -6\pmod{16}$ and the divisibility of $h$ is $2$, or $q_M(h)\equiv -6\pmod{144}$ and the divisibility of $h$ is $6$. We show that there exists a unique (up to isomorphism) slope stable vector bundle $\cal F$ on $M$ such that $r({\cal F})=4$, $ c_1({\cal F})=h$, $\Delta({\cal F})=c_2(M)$. Moreover $\cal F$ is rigid. One of our motivations is the desire to describe explicitly a locally complete family of polarized HK fourfolds of Kummer type.Comment: The present version is the final version, as it will appear on Epiga
Safety Assessment of Cellobiose as a Novel Food for Use in Food and Food Supplements (RP1109)
Authors:   Food Standards Agency,   Food Standards Scotland
Published: December 2024

The Food Standards Agency (FSA) and Food Standards Scotland (FSS) received an application from Savanna Ingredients GmbH (“the applicant”) for the authorisation of (2R,3S,4S,5R,6S)-2-(hydroxymethyl)​-​6-​[(2R,3S,4R,5R,6R)​-​4,5,6​-​trihydroxy​-​2​-​(hydroxymethyl)oxan​-​3​-​yl]oxyoxane-3,4,5-triol also known as Cellobiose, as a novel food in May 2021. The novel food is a disaccharide consisting of two glucose units linked by a β-1-4 glycosidic bond obtained from two-step enzymic conversion of sucrose and glucose into Cellobiose. This new application is seeking to use the novel food as an ingredient in various food categories including food supplements, to partially replace sugars such as lactose or sucrose, with the function of a low-calorie sweetener. The novel food ingredient and food supplements are not intended to be consumed by those under one year of age (infants). To support the FSA and FSS in their evaluation of the application, the Advisory Committee on Novel Foods and Processes (ACNFP) were asked to review the safety dossier and supplementary information provided by the applicant. The views of the Committee were taken into account by the FSA and FSS who concluded that the applicant had provided sufficient information to assure the novel food, Cellobiose, was safe under the proposed conditions of use. The anticipated intake levels and the intended use in food and food supplements was not considered to be nutritionally disadvantageous. This safety assessment represents the opinion of the FSA and FSS.
Navigating Dietary Complexities: Understanding Gluten Intolerance Awareness among Stakeholders
Authors: Sharma Sakshi , Sen Kriti 
Published: December 2024

Background: Eating out is not only a common trend these days but also necessity for many who live away from their families especially students pursuing higher education. With growing trend of food hypersensitivity catering industry needs to get driven for such special requirement. Objective: This study aimed to check the awareness of stakeholders for gluten intolerance with respect to the market and sensory evaluation of the developed alternative. Methodology: A cross-sectional study was conducted on consumers and food business operators of Central Delhi. Consumers were 18 years and above and claiming to be gluten intolerant. Food business operators were local shopkeepers running food stalls and bakery. A self -structured questionnaire was designed for stakeholders respectively. Developed gluten alternative was sensory evaluated by consumers on 9-point hedonic rating scale for its overall acceptability. Data was analyzed for the stakeholders by using descriptive statistics. Results: The results indicate that majority (53.65%) consumers were familiar with the symptoms of gluten intolerance like headache and digestive issues. Furthermore, majority (68.3%) identified rice and corn to be an alternative for gluten. Level of satisfaction from market for availability of alternatives is medium (61%).Sensory score for developed alternative was 7.19 ±1.53. Regarding food business operators’ majority (53.12%) receive customer request for availability of gluten free products, 46.87% are affirmative to provide alternatives subjected to demand of consumers. 53.12% also showcased interest in receiving training or resources for gluten intolerance and lactose free cooking skills and outsourcing of such food items. Conclusion: In general stakeholders showcased awareness about their food intolerance and improved availability of alternatives in market. At the same time willingness of food business operators to offer such products on menu. The study recommends to provide training to food business operators for provision of diversified menu for prospective consumers.
Relevansi Pemikiran Ibnu Khaldun dalam Pembelajaran Sejarah: Systematic Literature Review
Authors: Fadila Fadila , Mulyana Agus , Winarti Erlina 
Published: December 2024

Penelitian ini berjudul “Relevansi Pemikiran Ibnu Khaldun dalam Pembelajaran Sejarah” adapun latar belakang mengambil judul tersebut ialah Ibnu Khaldun merupakan tokoh ilmuan besar dari peradaban islam yang memiliki pemikiran yang besar terutama dalam sejarah. Tujuan penelitian ini untuk mengetahui apa saja relevansi pemikiran Ibnu Khaldun dalam pembelajaran sejarah. Metode penelitian yang gunakan penulis sebuah systematic literature review yang bertujuan untuk meninjau secara keseluruhan dan kritis mengenai relevansi pemikiran Ibnu Khaldun dalam pendidikan. Penelitian ini dilakukan terhadap artikel-artikel ilmiah tahun 2014-2023 data diperoleh dari artikel Google Schoolar, Elsiver, dan Science Direct yang relevan dengan pertanyaan penelitian. Setelah melalui proses penyaringan berdasarkan kriteria dan kualitas, diperoleh 15 artikel yang memenuhi syarat untuk menjawab pertanyaan penelitian. Hasil penelitian melaui tinjuan literatur dengan analisis kritis didapatkan bahwa pemikiran Ibnu Khaldun memberikan relevansi besar dalam pendidikan dan pembelajaran sejarah satu melalui karya besarnya “Muqaddimah” melalui pemikiran Ibnu Khaldun memberikan pencerahan mengenai sejarah dalam pembelajaran dengan menjabarkan pendidikan seperti tujuan pendidikan, sifat pendidik, sifat peserta didik, kurikulum dan metode pengajaran yang dapat dijadikan acuan bagi pendidik dalam melaksanakan pembelajaran sejarah disekolah.
Perspective of PPKN Stambuk 2022 Medan State University Students Regarding the 2024 Election Implementation System
Authors: Sinambela Sulastri , Pinem Octa Vioni , Panjaitan Novia , Hutabarat Lina , Halking Halking 
Published: December 2024

This research aims to examine and analyze directly the perspective of PPKN Stambuk 2022 students at Medan State University regarding the 2024 election implementation system. This mini-research proposal report will examine the perspective or level of understanding of PPKn Stambuk 2022 students regarding the election system. The aim of this mini research is to describe or illustrate the understanding of the 2022 PPKn Stambuk students at Medan State University regarding the 2024 election system in Indonesia. The research method used in this research is qualitative descriptive research. Data collection techniques through interviews, documentation and data sources taken from PPKn students to find out how the 2022 PPKN Stambuk Students at Medan State University understand the 2024 Election Implementation System. The results of the research show that students' understanding of the election system is concluded that the election system has a big role in optimization and voice his opinion according to his choice. The 2022 PPKn Stambuk students' opinions on the electoral system reflect the public's desire to participate actively in politics. The hope of PPKn Stambuk 2022 students is that the implementation of the election system can be better, starting from voter registration, counting to reporting results, which is carried out transparently.
Desafíos y aprendizaje: primera experiencia de fotoféresis en un niño con enfermedad de injerto contra receptor
Authors: Calderón Gasca Alejandra , Bula Anichiarico Doris Alexandra , Chaparro Alzogaray Mauricio , Estupiñán Peñaloza Marcela 
Published: December 2024

Graft-versus-Host Disease (GVHD) is a serious and common complication following allogeneic hematopoietic stem cell transplants (allo-HSCT), accounting for approximately 25% of post-transplant deaths. Its incidence, which has increased over the past two decades, reaches around 50% in patients undergoing allogeneic hematopoietic progenitor cell transplants. Factors such as patient age, the use of unrelated donors, reduced-intensity regimens, and specific sources of stem cells contribute to this increase. Initial treatment involves corticosteroids and calcineurin inhibitors, but in refractory cases, extracorporeal photopheresis (ECP) emerges as an option. Clinical case: We present the case of a pediatric patient undergoing haploidentical allogeneic hematopoietic progenitor cell transplant for severe aplastic anemia, who subsequently developed severe refractory chronic GVHD, with severe liver, skin and mild lung involvement, who underwent extracorporeal photopheresis sessions as part of the second line of GVHD treatment, with a partial response. Conclusion: the approach and treatment of GVHD results in the impossibility of a single treatment for all patients with this pathology.
Microphysical view of the development and ice production of mid-latitude stratiform clouds with embedded convection during an extratropical cyclone
Authors: Du Yuanmou , Liu Dantong , Zhao Delong , Huang Mengyu , Tian Ping , Wen Dian , Xiao Wei , Zhou Wei , He Hui , Pan Baiwan , Zuo Dongfei , Liu Xiange , Jing Yingying , Zhang Rong , Sheng Jiujiang , Wang Fei , Huang Yu , Chen Yunbo , Ding Deping 
Published: December 2024

Abstract. The microphysical properties associated with ice production importantly determine precipitation rates. In this study, the microphysical properties of stratiform clouds with embedded convection during an extratropical cyclone over northern China were characterized in situ. Stages of clouds, including young cells rich in liquid water and developing and mature stages with high number concentrations of ice particles (NIce), were investigated. NIce could reach 300 L−1 in the mature stage, approximately 2 orders of magnitude higher than the primary NIce. The secondary ice production (SIP) rate was 0.005–1.8 L−1 s−1, which was derived from the measured NIce. The SIP rate could be produced using a simplified collision–coalescence model by considering the collection of large droplets by graupel. The collection efficiency between the graupel and the droplet was found to increase when the size of the droplet approached that of the graupel, which may improve the agreement between the measurements and the model. Importantly, the overall NIce was found to be highly related to the distance to the cloud top (DCT). The level with a larger DCT had more rimed graupel falling from the upper levels, which promoted coalescence processes between the graupel and the droplets, producing a greater fraction of smaller ice. This seeder–feeder process extended the avalanche SIP process at lower temperatures to −14 °C, beyond the temperature region of the Hallett–Mossop process. The results illustrate the microphysical properties of clouds with convective cells at different stages, which will improve the understanding of the key processes in controlling the cloud glaciation and precipitation processes.
Review article: Physical vulnerability database for critical infrastructure hazard risk assessments – a systematic review and data collection
Authors: Nirandjan Sadhana , Koks Elco E. , Ye Mengqi , Pant Raghav , Van Ginkel Kees C. H. , Aerts Jeroen C. J. H. , Ward Philip J. 
Published: December 2024

Abstract. Critical infrastructure (CI) is exposed to natural hazards that may lead to the devastation of these infrastructures and burden society with the indirect consequences that stem from this. Fragility and vulnerability curves, which quantify the likelihood of a certain damage state and the level of damage of an element under varying hazard intensities, play a crucial role in comprehending, evaluating, and mitigating the damage posed by natural hazards to these infrastructures. To date, however, these curves for CI have been distributed across the literature instead of being accessible through a centralized database. This study, through a systematic literature review, synthesizes the state of the art of fragility and vulnerability curves for the CI assets of energy, transport, water, waste, telecommunication, health, and education in context of natural hazards and offers a unique physical vulnerability database. The publicly available centralized database that contains over 1510 curves can directly be used as input for risk assessment studies that evaluate the potential physical damage to assets due to flooding, earthquakes, windstorms, and landslides. The literature review highlights that vulnerability development has mainly focused on earthquake curves for a wide range of infrastructure types. The curves for windstorms have the second largest share in the database, but they are especially limited to energy curves. While all CI systems require more vulnerability research, additional efforts are needed for telecommunication, which is largely underrepresented in our database.
Designing wind turbines for profitability in the day-ahead market
Authors: Mehta Mihir Kishore , Zaaijer Michiel , von Terzi Dominic 
Published: December 2024

Abstract. Traditionally, wind turbine and wind farm designs have been optimized to minimize the cost of energy. Such a design would make sense when bidding in price-based auctions. However, in a future with a high share of renewables and zero subsidies, the wind farm developer is exposed to the volatility of market prices, where the price paid per kilowatt-hour of energy would not be constant anymore. The developer might then have to maximize the revenue earned by participating in different energy, capacity, or ancillary services markets. In such a scenario, a turbine designed for maximizing its market value could be more profitable for the developer compared to a turbine designed for minimizing the levelized cost of electricity (LCoE). This study is in line with this paradigm shift in the field of turbine and farm design. It is a continuation of a previous study conducted by the same authors (Mehta et al., 2024), which explicitly focused on the drivers of turbine sizing with respect to LCoE. The goal of this study is to optimize the design for a new set of objective functions and analyze how various day-ahead market conditions and objectives drive turbine design. A simplified market model that can generate hourly day-ahead market prices is developed and coupled with a wind-farm-level multidisciplinary design analysis and optimization (MDAO) framework to evaluate key economic indicators of the wind farm. The results show how the optimum turbine design is driven by both the choice of the economic metric and the market scenario. However, an LCoE-optimized design is found to perform well with respect to profitability-based economic metrics like modified internal rate of return (MIRR) or profitability index (PI), indicating a limited need to redesign turbines for a specific day-ahead market scenario.
Opiniones sobre las mujeres ucranianas en el conflicto armado: la influencia del sexismo
Authors: Coronel Sandoval Rocío Agustina , Vera Gil Sara 
Published: December 2024

Introducción. Tras las acciones militares por parte de Rusia, la población ucraniana se ha sumido en una profunda crisis humanitaria. Los conflictos armados se caracterizan por ser paternalistas, androcéntricos y por perpetuarse gracias al sexismo. En este contexto, el sexismo se exacerba y las mujeres y sus cuerpos son, una vez más, objeto de opinión. Nuestra investigación se centra en estudiar la influencia del sexismo a la hora de explicar el papel de las ucranianas en el conflicto bélico actual, así como en determinar, los niveles de sexismo y la influencia del género, la edad y el nivel educativo sobre el mismo. Metodología. Se llevó a cabo una investigación cuantitativa transversal de muestreo de conveniencia basado en la edad, contando con 146 participantes a quienes se aplicó el Inventario de Sexismo Ambivalente y un cuestionario basado en opiniones estereotípicas vertidas en redes sociales sobre las ucranianas. Resultados. Se encontraron diferencias en mujeres y en hombres, tanto en los niveles de sexismo como en la influencia de la edad y el nivel educativo sobre estos. En cuanto a la influencia del sexismo sobre la opinión del papel de las mujeres en la guerra de Ucrania, se obtuvo una fuerte relación positiva para ambos grupos. Por último, las puntuaciones medias obtenidas tanto por hombres como por mujeres en este mismo cuestionario fueron bajas, lo que refleja un desacuerdo generalizado con las afirmaciones estereotípicas. Discusión. Destacamos el impacto diferencial que el movimiento feminista ha tenido en mujeres y en hombres, así como la necesidad de continuar apostando por una educación con perspectiva de género que ayude a reducir los niveles de sexismo en los hombres, así como su implicación como aliados en la confrontación del mismo.
UTILITAS PEMBERIAN EDUKASI PERILAKU HIDUP BERSIH DAN SEHAT (PHBS) BAGI KUALITAS PSIKOLOGIS ANAK BINAAN DI LEMBAGA PEMBINAAN KHUSUS ANAK KELAS II JAKARTA
Authors: Arzethy Putri Laura , Muhammad Ali , Anwar Umar 
Published: December 2024

Perilaku hidup bersih dan sehat (PHBS) menjadi modal dasaar untuk meningkatkan kualitas kesehatan setiap individu. Lembaga Pembinaan Khusus Anak (LPKA) Kelas II Jakarta sebagai lembaga penempatan Anak yang Berkonflik dengan Hukum (ABH) tentunya penting untuk menanamkan pola hidup bersiah dan sehat (PHBS) selama Anak menjalani masa pembinaannya. Berdasarkan hasil observasi, wawancara dan kuesioner yang ditanyakan kepada 26 Anak Binaan kondisi kebersihan dan kesehatan Anak banyak terkendala oleh ketersediaan sarana dan prasarana saniitasi hygiene di LPKA, kondisi ini semakin diperburuk oleh kondisi pemahaman Anak tentang perilaku Hidup Bersih dan Sehat (PHBS) hal inilah yang berdampak kepada kualitas kesehatan psikologis Anak. Selain hal tersebut, Anak Binaan masih kurang memahami sepenuhnya arti penting dari Perilaku Hidup Bersih dan Sehat (PHBS) itu sendiri. Kualitas kesehatan psikologis Anak berdampak kepada perilaku Anak yang cenderung membatasi aktivitas kebersihannya dan Anak malas untuk menjaga kebersihan diri dan lingkungan sekitar. Hal ini menyebabkan Anak Binaan rentan terjangkit penyakit kulit, seperti Rabi atau Skabies. Metode yang digunakan Taruna dalam pelaksanaan praktikum pengabdian ini adalah Metode Community Development dalam membantu Lembaga Pembinaan Khusus Anak Kelas II Jakarta yang bertujuan untuk mencapai peningkatan penerapan Perilaku Hidup Bersih dan Sehat (PHBS) dengan menggunakan teknik kolaborasi dan sosialisasi atau penyuluhan, yaitu Taruna bersama dengan Lembaga Pembinaan Khusus Anak Kelas II Jakarta berkolaborasi bersama melakukan kegiatan dengan teknik sosialisasi atau penyuluhan guna meningkatkan kesadaran dan motivasi Anak Binaan dalam menerapkan Perilaku Hidup Bersih dan Sehat (PHBS) meskipun ditengah keterbatasan. Di akhir praktikum, terdapat peningkatan kesadaran dan aktivitas personal hygiene oleh Anak Binaan dalam menerapkan Perilaku Hidup Bersih dan Sehat (PHBS) selama di Lembaga Pembinaan Khusus Anak Kelas II Jakarta.
Sistem Pendukung Pengambilan Keputusan Pemilihan Objek Wisata Menggunakan Metode TOPSIS Studi Kasus Kabupaten Bengkayang
Authors: Redina anjelina Nathania , Vika  , Melindaria  , Sari Lili Lerian , Indramayu  , Leopaldo Martino Rios  , Noviyanti. P  
Published: December 2024

Sistem pendukung keputusan telah menjadi bagian penting dalam mengoptimalkan proses pengambilan keputusan di berbagai bidang, seperti pemilihan objek wisata. Pemilihan tempat wisata yang tepat sangat penting untuk meningkatkan daya tarik suatu destinasi dan memenuhi kebutuhan pengunjung. Dalam konteks ini menggunakan metode TOPSIS (teknik penentuan prioritas berdasarkan kemiripan dengan solusi ideal) digunakan sebagai pendekatan untuk mengatasi kompleksitas dan berbagai kriteria dalam pengambilan keputusan. Sistem Pendukung Pengambilan Keputusan yang diusulkan menggunakan metodologi TOPSIS untuk mengklasifikasikan dan mengevaluasi atraksi wisata alternatif berdasarkan serangkaian kriteria yang relevan. Kriteria tersebut dapat mencakup aspek-aspek seperti keindahan alam, fasilitas, aksesibilitas, kelestarian lingkungan, dan faktor ekonomi. Masing-masing kriteria diberi bobot berdasarkan kepentingannya dan diberi peringkat dengan mempertimbangkan kedekatan relatifnya dengan objek wisata serta solusi ideal positif dan negatif. Keunggulan utama sistem ini antara lain mampu menangani kompleksitas beberapa kriteria, mampu menyesuaikan bobot kriteria secara fleksibel sesuai preferensi pengguna, serta memberikan solusi yang lebih obyektif dan terukur dalam proses pengambilan keputusan. Pedoman berharga bagi pemangku kepentingan dalam menyusun strategi promosi, pengelolaan dan pengembangan daya tarik wisata.
RNA Devices for Therapeutic Applications: Progress, Challenges and Future Perspective
Authors: Dwivedi Vibha , Yun-Xing Wang  
Published: December 2024

Review
RNA Devices for Therapeutic Applications: Progress, Challenges and Future Perspective

Vibha Dwivedi * and Yun-Xing Wang

Protein-Nucleic Acid Interaction Section, Center for Structural Biology, National Cancer Institute, National Institutes of Health, Frederick, MD 21702, USA
* Correspondence: vibha.dwivedi@nih.gov

Received: 10 October 2024 2024; Revised: 21 October 2024; Accepted: 30 October 2024; Published: 1 November 2024

Abstract: Advances in RNA structural biology and engineering have stimulated thinking of using engineered RNA devices for precision cell and gene therapy. The RNA devices provide distinct advantages over existing approaches. Riboswitches, the key element in RNA devices, are regulatory structural elements found within mRNA in all three kingdoms of life but mostly in bacteria to sense the concentrations of small molecule metabolites, pathway products, uncharged tRNA and elemental ions for regulation of gene expression. Because of non-immunogenicity and several other advantages, riboswitches are considered to be a promising tool that may have significant implications in medicine and health. This review will provide an overview on the structural studies of key motifs critical for RNA device functions and some of the pioneering works aimed at developing RNA based therapeutics for medicine.