bluuebunny/crossref_metadata_2025_split huggingface dataset:
Influence of hyper‐harmonized fullerene water complex on collagen quality and skin function
Authors: Miljkovic Suzana , Jeftic Branislava , Sarac Dusan , Matovic Valentina , Slavkovic Marija , Koruga Djuro 
Published: May 2019

AbstractBackgroundFullerene water complex establishes the optimal order and function of biomolecules in natural, biophysical way by transducing the signal through water hydrogen bonds to biomolecules.ObjectivesThis paper considers the effects of the patented hyper‐harmonized‐hydroxylated fullerene water complex (3HFWC) on biophysical properties of the skin collagen molecules.MethodOptomagnetic imaging spectroscopy (OMIS) has been used for the analysis of the biophysical skin properties (diamagnetic/paramagnetic) after applying three groups of different cosmetic products. Tested cosmetic products were prepared by replacing the active ingredients with 3HFWC or with water in four commercial products. The original commercial creams and their vehiculums with water added served as control groups. Data were statistically analyzed using paired t test in R software.Resultst Test gave statistically significant results for all of the products with 3HFWC, while within the control group, only body lotion and hand cream did show statistically significant results (P < 0.05). Significant improvements in abundance and quality of collagen in the dermis were achieved with body lotion with 3HFWC (p+/p−ranged from 0.82 to 0.97). While body lotion vehiculum made collagen‐water interaction more stable (p+/p−ranged from 0.3 to 0.55), hand cream with 3HFWC made it more dynamic (p+/p−ranged from 0.63 to 0.49). Body lotion vehiculum improved the compactness of the dermis (p+/p−ranged from 0.2 to 1.03), as well as commercial hand cream (p+/p− ranged from 0.28 to 0.85).ConclusionCompared to the control groups, cosmetic products with 3HFWC demonstrated positive effects on the biophysical properties of the skin. Increased paramagnetic properties are linked to more unpaired electrons, their faster movement, and, finally, better signal transduction. Thus, products with 3HFWC could enable faster regeneration of collagen and prompt skin reaction to the negative environmental influences.
Efficacy of high‐intensity focused ultrasound in facial and neck rejuvenation
Authors: Aşiran Serdar Zehra , Aktaş Karabay Ezgi , Tatlıparmak Aslı , Aksoy Berna 
Published: May 2019

AbstractBackgroundHigh‐intensity focused ultrasound (HIFU) has recently been introduced in the treatment of facial wrinkles and laxity.ObjectiveThe purpose of the study was to evaluate efficacy and safety of HIFU in facial and neck rejuvenation.MethodsHigh‐intensity focused ultrasound treatment was performed on face and neck by using two different probes with focal depth of 3 mm and 4.5 mm. Two independent, blinded clinicians evaluated the clinical improvement at 3 months after treatment. The patients also scored their satisfaction with the treatment. Adverse effects were assessed up to 3 months post‐treatment.ResultsSeventy‐five patients (73 female, 2 male) with Fitzpatrick skin phototypes 2‐4 were enrolled in the study. After treatment, improvement in nasolabial, jawline, submental, and neck areas was separately evaluated. The rate of improvement in each area was more than 80% according to the physicians' assessment, while patients' satisfaction degree in each area was over 78%. Most common adverse effect was pain, reported in 25.3% of the patients during the procedure while transient erythema was reported in 6.7%. Both resolved spontaneously after the procedure. Only one patient complained development of numbness on right mandibular region which resolved spontaneously within 10 days.ConclusionHigh‐intensity focused ultrasound can be an effective noninvasive treatment modality in facial and neck rejuvenation with an acceptable safety profile.
The Silent Backdrop: Colonial Anxiety at the Border
Authors: Carver Natasha 
Published: May 2019

AbstractThrough the categorization of movers, states determine and fix the belonging of migrants and thereby reproduce the nation‐state system as a global reality. Some movers, however, are deemed illegible and must be identified, labelled and thus brought within the system. This paper unpicks the legal consequences of a “coloniality of power” (Quijano, 2000) embedded within the border system as a whole. The paper demonstrates this process through a post‐colonial examination of Somali migration and the application of the 1951 Refugee Convention at the UK border. The Somali migrant, like his colonized predecessor, is constructed as an unreliable informant of him/herself; a “lying native” (Bhabha, 1994) whose identity can be ‘discovered’ by the tools of the enlightened West.
Circulating microRNAs in suspected stable coronary artery disease: A coronary computed tomography angiography study
Authors: de Gonzalo‐Calvo David , Vilades David , Martínez‐Camblor Pablo , Vea Àngela , Nasarre Laura , Sanchez Vega Jesus , Leta Rubén , Carreras Francesc , Llorente‐Cortés Vicenta 
Published: May 2019

AbstractObjectivesTo explore the diagnostic performance of circulating microRNAs (miRNAs) as biomarkers in patients with suspected stable coronary artery disease (CAD).MethodsPlasma samples were collected from 237 consecutive patients referred for coronary computed tomography angiography (CCTA). Presence, extension and severity of coronary stenosis were evaluated using the indexes: presence of diameter stenosis ≥ 50%, segment involvement score (SIS), segment stenosis score (SSS) and 3‐vessel plaque score. A panel of 10 miRNAs previously associated with CAD was analysed using RT‐qPCR. Multivariate analyses were used to analyse the associations between biomarkers and indexes. Discrimination was evaluated using the area under the ROC curve (AUC). Decision trees were generated using chi‐squared Automatic Interaction Detector (CHAID) prediction models.ResultsAfter comprehensive adjustment including cardiovascular risk factors, medication use, confounding factors and protein‐based biomarkers (hs‐TnT and hs‐CRP), several circulating miRNAs were inversely associated with coronary atherosclerosis extension (SIS and 3‐vessel plaque score) and severity (SSS). In the whole population, circulating miRNAs showed a poor discrimination value for all indexes (AUC = 0.539–0.644) and did not increase the discrimination capacity of a clinical model of coronary stenosis presence, extension and severity based on conventional cardiovascular risk factors. Conversely, the inclusion of circulating miRNAs in decision trees produces models that improve the classification of cases and controls in specific patient subgroups.ConclusionsThis study identifies a group of circulating miRNAs that failed to improve the discrimination capacity of cardiovascular risk factors but that has the potential to define specific subpopulations of patients with suspected stable CAD.
Effects of chronic treatment with botulinum toxin type A in salivary glands of rats: Histological and immunohistochemical analyses
Authors: Regueira Luciana Silva , Baratella‐Evêncio Liriane , de Oliveira Jaciel Benedito , da Silva Priscilla Suelen Oliveira Carvalho , Valença Gabriela Andrade Lima , Conceição Juliana Cristina Peixoto , da Cruz Perez Danyel Elias 
Published: May 2019

AbstractBackgroundThe intraglandular application of botulinum neurotoxin type A (BoNT‐A) is used in patients with neuromotor disorders to control the escape of saliva. The aim of this study was to analyze the impact of repeated treatment with BoNT‐A on the submandibular‐sublingual complex of rats.MethodsA total of 35 Wistar rats were divided into three groups: control group (C), in which animals were not treated; group B, treated with 2.5 U intraglandular injections of BoNT‐A (Prosigne®) and group G, that received bovine gelatine (Prosigne stabilizer). Three applications were performed in intervals of 35 days. Twelve and 35 days after ending the treatment, submandibular‐sublingual complex was collected for histological analysis. Immunohistochemical reactions for calponin and specific muscle actin were also performed, besides detection of apoptosis by terminal deoxynucleotidyl transferase‐mediated dUTP nick end labeling (TUNEL) assay.ResultsA decrease in mucosal and serous acini diameter was observed, with increased interstitial space after 12 days of treatment with BoNT‐A, which was observed in a lesser degree on the 35th day. At 12 days, immunohistochemical analysis revealed a decrease in myoepithelial cells of serous acini in group B. TUNEL methods evidenced apoptosis in animals from group B.ConclusionsBoNT‐A caused histological and cellular changes in submandibular‐sublingual complex, followed by a tendency toward reversal after 35 days. The reversal characteristic of cellular changes in the submandibular‐sublingual complex suggests that this BoNT‐A formulation may be safely used for sialorrhea treatment.
Accuracy of School Staff‐Measured Height and Weight Used for Body Mass Index Screening and Reporting
Authors: Thompson Hannah R. , Linchey Jennifer K. , King Benjamin , Himes John H. , Madsen Kristine A. 
Published: May 2019

ABSTRACTBACKGROUNDThe accuracy of students' heights and weights measured by school staff for body mass index (BMI) screening/reporting has not been established. This study examined school staffs' measurement accuracy, comparing accuracy by staff‐ and student‐level characteristics.METHODSSchool staff and researchers measured the height and weight of 1008 4th–8th grade students, within 1 month of each other. Bland–Altman plots, mean differences, and intraclass correlation coefficients (ICCs) were calculated to examine measurement accuracy. Linear mixed effects models assessed accuracy by staff‐ and student‐level characteristics.RESULTSBland–Altman plots revealed no appreciable bias in differences between researcher and staff measurements. The mean absolute difference between researcher and school staff measurements were 1.0 ± 1.6 cm (height), 0.7 ± 1.8 kg (weight), and 0.4 ± 0.8 kg/m2 (BMI). Inter‐rater ICC values were ≥0.97, demonstrating “excellent” reliability. Categorical weight status was correctly classified for 94% of students (kappa 0.90), and for 96% with a BMI ≥95th% (kappa 0.94). Physical education (PE) teachers were slightly less accurate than school nurses in measuring height (0.4 cm less accurate; p = .045) and weight (0.4 kg; p = .015).CONCLUSIONSSchool staff conducted height/weight measurements on 4th–8th grade students with high accuracy. Resultant school‐based BMI reports using similar protocols should validly reflect weight status for almost all students.
Youth version, Case‐finding and Help Assessment Tool (YouthCHAT): An electronic, psychosocial screener for young people with long‐term physical conditions
Authors: Thabrew Hiran , Goodyear‐Smith Felicity 
Published: May 2019

AimThis study investigated the acceptability, clinical utility and preliminary effectiveness of Youth version, Case‐finding and Help Assessment Tool (YouthCHAT), a novel electronic, tablet‐based screener designed to identify issues similar to Home, Education/Employment, Activity, Drugs, Sexuality, Suicide/Depression, Safety assessment.MethodsYouthCHAT was administered to a group of 30 young people aged 13–17 years with different long‐term physical conditions attending outpatient clinics between September and December 2017. Outcome measures were: (i) acceptability and feasibility of YouthCHAT as assessed via feedback from young people and clinicians and the time taken to complete YouthCHAT screening; and (ii) detection rates for each domain of YouthCHAT measured by mental health or life‐style issues ‘present’ or ‘absent’, and where relevant, validated symptom scores.ResultsYouthCHAT was quick to administer and positively received by both young people and clinicians. Rates of anxiety (37%) and depression (13%) detected using YouthCHAT were similar to those in previous studies of young people with long‐term physical conditions. Rates of other problems were similar to a previously screened high school sample.ConclusionsYouthCHAT is a viable and acceptable psychosocial screener with the potential to improve the holistic care of young people with long‐term physical conditions attending outpatient clinics. Trial Registration: This study has been registered with the Australian New Zealand Clinical Trials Network Registry ACTRN12616001243404p.
Effect of the β‐carotene oxygenase 2 genotype on the content of carotenoids, retinol and α‐tocopherol in the liver, fat and milk of rabbit does, reproduction parameters and kitten growth
Authors: Strychalski Janusz , Gugołek Andrzej , Brym Paweł , Antoszkiewicz Zofia 
Published: May 2019

AbstractMutations in the β‐carotene oxygenase 2 (BCO2) gene can impair the function of the enzyme that breaks down carotenoids. As a result, gradual accumulation of unoxidized carotenoids in animal tissues gives them a yellow colour. The aim of the study was to determine the content of carotenoids, retinol and α‐tocopherol in the liver, fat and milk of rabbit does with three different genotypes determined by AAT‐deletion mutation at codon 248 of the BCO2 gene and to find out whether differences in the concentrations of the above compounds in the tissues and milk of the does affect reproduction parameters and the rearing rate of kittens. The experimental materials comprised 36 does, 12 of each genotype of the BCO2 gene, with their litters. Females with their litters were placed in individual cages, on deep litter. Between days 7 and 13 of lactation, samples of milk were collected from the does. The kittens stayed with their mothers until 35 days of age. After weaning, the does were sacrificed. Tissue samples of liver and perirenal fat were collected for chemical analyses. Additionally, based on samples taken from one female, RNA expression levels were determined from the mammary gland and liver, adipose tissue and skin. It was found that homozygous does with deletion at codon 248 of the BCO2 gene were characterized by considerably higher concentrations of xanthophylls and beta‐carotene in the liver, adipose tissue and milk than does with the remaining genotypes. However, the differences in the content of the above compounds in milk had no influence on litter weight or the number and rearing rate of kittens. Additionally, RNA expression of the BCO2 gene was found in the mammary tissue of lactating doe and its level was similar to those noted in the liver and adipose tissue.
Ultraprecise age and formation temperature of the Australasian tektites constrained by40Ar/39Ar analyses
Authors: Jourdan Fred , Nomade Sebastien , Wingate Michael T. D. , Eroglu Ela , Deino Al 
Published: May 2019

AbstractThe Australasian tektites are quench melt glass ejecta particles distributed over the Asian, Australian, and Antarctic regions, the source crater of which is currently elusive. New40Ar/39Ar age data from four tektites: one each from Thailand, China, Vietnam, and Australia measured using three different instruments from two different laboratories and combined with published40Ar/39Ar data yield a weighted mean age of 788.1 ± 2.8 ka (±3.0 ka, including all sources of uncertainties) (P = 0.54). This age is five times more precise compared to previous results thanks, in part, to the multicollection capabilities of theARGUS VInoble gas mass spectrometer, which allows an improvement of almost fourfold on a single plateau age measurement. Diffusion experiments on tektites combined with synthetic age spectra and Monte Carlo diffusion models suggest that the minimum temperature of formation of the Thai tektite is between 2350 °C and 3950 °C, hence astrict minimumvalue of 2350 °C.
An Early Jurassic age for the Puchezh‐Katunki impact structure (Russia) based on40Ar/39Ar data and palynology
Authors: Holm‐Alwmark S. , Alwmark C. , Ferrière L. , Lindström S. , Meier M. M. M. , Scherstén A. , Herrmann M. , Masaitis V. L. , Mashchak M. S. , Naumov M. V. , Jourdan F. 
Published: May 2019

AbstractThe Puchezh‐Katunki impact structure, 40–80 km in diameter, located ~400 km northeast of Moscow (Russia), has a poorly constrained age between ~164 and 203 Ma (most commonly quoted as 167 ± 3 Ma). Due to its relatively large size, the Puchezh‐Katunki structure has been a prime candidate for discussions on the link between hypervelocity impacts and extinction events. Here, we present new40Ar/39Ar data from step‐heating analysis of five impact melt rock samples that allow us to significantly improve the age range for the formation of the Puchezh‐Katunki impact structure to 192–196 Ma. Our results also show that there is not necessarily a simple relationship between the observed petrographic features of an impact melt rock sample and the obtained40Ar/39Ar age spectra and inverse isochrons. Furthermore, a new palynological investigation of the postimpact crater lake sediments supports an age significantly older than quoted in the literature, i.e., in the interval late Sinemurian to early Pliensbachian, in accordance with the new radioisotopic age estimate presented here. The new age range of the structure is currently the most reliable age estimate of the Puchezh‐Katunki impact event.
Host genetic determinants of the gut microbiota of wild mice
Authors: Suzuki Taichi A. , Phifer‐Rixey Megan , Mack Katya L. , Sheehan Michael J. , Lin Dana , Bi Ke , Nachman Michael W. 
Published: May 2019

AbstractIdentifying a common set of genes that mediate host–microbial interactions across populations and species of mammals has broad relevance for human health and animal biology. However, the genetic basis of the gut microbial composition in natural populations remains largely unknown outside of humans. Here, we used wild house mouse populations as a model system to ask three major questions: (a) Does host genetic relatedness explain interindividual variation in gut microbial composition? (b) Do population differences in the microbiota persist in a common environment? (c) What are the host genes associated with microbial richness and the relative abundance of bacterial genera? We found that host genetic distance is a strong predictor of the gut microbial composition as characterized by 16S amplicon sequencing. Using a common garden approach, we then identified differences in microbial composition between populations that persisted in a shared laboratory environment. Finally, we used exome sequencing to associate host genetic variants with microbial diversity and relative abundance of microbial taxa in wild mice. We identified 20 genes that were associated with microbial diversity or abundance including a macrophage‐derived cytokine (IL12a) that contained three nonsynonymous mutations. Surprisingly, we found a significant overrepresentation of candidate genes that were previously associated with microbial measurements in humans. The homologous genes that overlapped between wild mice and humans included genes that have been associated with traits related to host immunity and obesity in humans. Gene–bacteria associations identified in both humans and wild mice suggest some commonality to the host genetic determinants of gut microbial composition across mammals.
Fluid flow rate dictates the efficacy of low‐intensity anti‐vascular ultrasound therapy in a microfluidic model
Authors: DeOre Brandon J. , Galie Peter A. , Sehgal Chandra M. 
Published: May 2019

AbstractObjectiveLow‐intensity anti‐vascular ultrasound therapy is an effective means of disrupting the blood supply in the tumor microenvironment. Its diminished effect on the surrounding vasculature is thought to be due to higher blood flow rates outside the tumor that decreases the interaction time between the endothelial lining and the microbubbles, which transduce acoustic energy to thermal heat. However, investigating the effect of circulation rate on the response to low‐intensity ultrasound is complicated by the heterogeneity of the in vivo vascular microenvironment. Here, a 3D microfluidic model is used to directly interrogate the dynamics of ultrasound stimulation.MethodsA 3D in vitro vessel consisting of LifeACT transfected endothelial cells facilitate real‐time analysis of actin dynamics during ultrasound treatment. Using an integrated testing platform, both the flow rate of microbubbles within the vessel and the magnitude of insonation can be varied.ResultsMorphological measurements and dextran transport assays indicate that lower flow rates exacerbate the effect of low‐intensity ultrasound on vessel integrity. Additionally, immunostaining for VE‐cadherin and transmission electron microscopy provide further insight into structural changes in cell‐cell junctions following insonation. ConclusionsOverall, these results reveal that blood flow rate is an important parameter to consider during the refinement of anti‐vascular low‐intensity ultrasound therapies.
World Workshop on Oral Medicine VII: Functional pathways involving differentially expressed lncRNAs in oral squamous cell carcinoma
Authors: Pentenero Monica , Bowers Leah , Jayasinghe Ruwan , Cheong Sok Ching , Farah Camile S. , Kerr Alexander R. , Alevizos Ilias 
Published: May 2019

AbstractLong non‐coding RNAs (lncRNA) modulate gene expression at the epigenetic, transcriptional and post‐transcriptional levels and are involved in tumorigenesis. They can form complex secondary and tertiary structures and have been shown to act as precursors, enhancers, reservoirs and decoys in the complex endogenous RNA network. They were first reported in relation to oral squamous cell carcinoma (OSCC) in 2013. Here, we summarise the functional roles and pathways of the most commonly studied lncRNAs in OSCC. Existing research demonstrates the involvement of lncRNA within pivotal pathways leading to the development and spread of OSCC, including interactions with key cancer‐associated microRNAs such as miR‐21. The number of studies on lncRNA and OSCC remains limited in this new field. As evidence grows, the tissue‐specific expression patterns of lncRNAs should further advance our understanding of the altered regulatory networks in OSCC and possibly reveal new biomarkers and therapeutic targets.
World Workshop in Oral Medicine VII: Reporting of IMMPACT‐recommended outcome domains in randomized controlled trials of burning mouth syndrome: A systematic review
Authors: Farag Arwa M. , Albuquerque Rui , Ariyawardana Anura , Chmieliauskaite Milda , Forssell Heli , Nasri‐Heir Cibele , Klasser Gary D. , Sardella Andrea , Mignogna Michele D. , Ingram Mark , Carlson Charles R. , Miller Craig S. 
Published: May 2019

AbstractObjectivesTo determine the frequency of use of the core outcome domains published by the Initiative on Methods, Measurement, and Pain Assessment in Clinical Trials (IMMPACT) in burning mouth syndrome (BMS) randomized controlled trials (RCTs).MethodsThis systematic review, conducted as part of the World Workshop on Oral Medicine VII (WWOM VII), was performed by searching the literature for studies published in PubMed, Web of Science, PsycINFO, Cochrane Database/Cochrane Central, and Google Scholar from January 1994 (when the first BMS definition came out) through October 2017.ResultsA total of 36 RCTs (n = 2,175 study participants) were included and analyzed. The overall reporting of the IMMPACT core and supplemental outcome domains was low even after the publication of the IMMPACT consensus papers in 2003 and 2005 (mean before IMMPACT consensus publication = 2.6 out of 6; mean after IMMPACT publication = 3.8 out of 6). Use of validated assessment tools recommended by the IMMPACT consensus was scarce (1.9 out of 6). None of the RCTs reviewed cited the IMMPACT consensus papers.ConclusionsThe underreporting of IMMPACT outcome domains in BMS RCTs is significant. Raising awareness regarding the existence of standardized outcome domains in chronic pain research is essential to ensure more accurate, comparable, and consistent interpretation of RCT findings that can be clinically translatable.