bluuebunny/crossref_metadata_2025_split huggingface dataset:
CaMKII Exacerbates Doxorubicin‐Induced Cardiotoxicity by Promoting Ubiquitination Through USP10 Inhibition
Authors: Yang Yitong , Wang Zhenyi , Wang Nisha , Yang Jian , Yang Lifang 
Published: November 2024

ABSTRACTBackgroundDoxorubicin (DOX) is an effective anticancer drug, but it has a problem of cardiotoxicity that cannot be ignored. Ca2+/calmodulin‐dependent protein kinase II (CaMKII) is tightly associated with the pathological progression of DOX‐induced cardiotoxicity. Ubiquitin‐specific protease 10 (USP10) plays an important role in many biological processes and cancers. However, its association with DOX‐induced cardiotoxicity and CaMKII remains unclear.MethodsH9C2 cells, HL‐1 cells and C57BL/6 mice were used to establish the DOX‐induced cardiotoxicity model, and the CaMKII‐specific inhibitor KN‐93 and USP10 specific inhibitor Spautin‐1 were used to observe the CaMKII and USP10 effect. In cell experiments, CCK‐8 method was used to assess cell viability, LDH kit was used to assess lactate dehydrogenase expression, DCFH‐DA staining was used to observe changes in active oxygen content, TUNEL staining was used to observe cell apoptosis, and Western blotting method was used to detect relevant protein markers. The expression of p‐CaMKII and USP10 was assessed by immunofluorescence staining. In animal experiments, mouse echocardiograph was used were used to evaluate cardiac function, and HE staining and Masson staining were used to evaluate myocardial injury. Cardiomyocyte apoptosis was detected by TUNEL staining. Western blotting method was used to detect relevant protein markers.ResultsOur results demonstrated that activation of CaMKII and inhibition of USP10 pathway related to DOX‐induced cardiotoxicity. Inhibition of CaMKII with KN‐93 ameliorated DOX‐induced cardiac dysfunction and cytotoxicity. In addition, CaMKII inhibition prevented DOX‐induced apoptosis and ubiquitination. Furthermore, CaMKII inhibition increased USP10 expression in DOX‐treated mouse hearts, H9C2 cells and HL‐1 cells. At last, the USP10 inhibitor, Spautin‐1, blocked the regulatory effect of CaMKII inhibition on apoptosis and ubiquitination in DOX‐induced cardiotoxicity.ConclusionOur findings revealed that DOX‐induced myocardial apoptosis and activated CaMKII through cellular and animal levels, while providing a novel probe into the mechanism of CaMKII action: promoting ubiquitination by inhibiting USP10 aggravated apoptosis.
Synthesizing Lactic Acid by the Manganese‐Catalyzed Dehydrogenative Coupling of Ethylene Glycol and Methanol
Authors: Ding Jiaqiao , Lv Shan , Shao Xiulan , Cui Bing , Zhao Mingqin , Shao Zhihui 
Published: November 2024

AbstractHerein, an efficient and green procedure for the synthesis of lactic acid via the dehydrogenative coupling of ethylene glycol with methanol is reported. The reaction is carried out under mild conditions in the presence of a catalytic amount of CyPNP‐Mn as the catalyst and tBuOK as the base and is an example of the deoxygenative coupling of a lower alcohol to form lactic acid via elegant metal–ligand cooperation with a homogeneous non‐noble‐metal catalyst in >99% conversion and selectivity. This transformation proceeds at low catalyst loading (0.00625 mol%) with a high turnover number (TON) of up to 6080 for lactic acid.
Towards Sustainable Battery Recycling: Selective Desorption of Nickel(II) and Cobalt(II) from Amino‐Polycarboxylate Derivate Ligands in Model Systems
Authors: Robeck Björn , Hoff Katharina , Horn Helena 
Published: November 2024

AbstractInter alia due to the high demand for lithium‐ion batteries, the required critical heavy metals have become a scarce resource. Consequently, effective recycling processes that enable the recovery of such materials are of high interest. A silica adsorbent functionalized with amino‐polycarboxylate derivate ligands (HSU331) was applied in order to selectively adsorb nickel(II) and cobalt(II). Subsequently, suitable parameters for a pH‐swing desorption were investigated. Maximum desorption efficiencies for Co(II) were achieved at pH = 2.7 (72 %) and for Ni(II) at pH = −0.5 (94 %). These results were used for the design of a pH‐shift desorption process in order to selectively recover Co(II) and regenerate the adsorbent after simultaneous adsorption of Co(II) and Ni(II).
Impact of the P‐Ligand Concentration on the Formation of Hydroformylation Catalysts: An in situ FTIR Spectroscopic Study
Authors: Wei Chunhong , Leidecker Benedict N. , Peña Fuentes Dilver , Schröder Henning , Sawall Mathias , Neymeyr Klaus , Kondratenko Evgenii V. , Börner Armin , Franke Robert , Kubis Christoph 
Published: November 2024

AbstractThe formation of hydrido rhodium(I) complexes of the type [HRh(CO)3L] and [HRh(CO)2L2] from [Rh(acac)(CO)2]/L (L: bulky monophosphite ligand) requires a ligand‐to‐rhodium ratio [L]/[Rh] > 10 to prevent the possible partial generation of [Rh6(CO)16] under typical hydroformylation conditions. Significant fractions of formed [Rh6(CO)16] at lower ratios of [L]/[Rh] can be reactivated towards the hydrido complexes after the addition of the monophosphite ligand in the presence of synthesis gas. It was also found that [Rh6(CO)16] can be transformed by treatment with an excess of monophosphite ligand under inert gas to form a mononuclear complex of the type [L`Rh(CO)L] with an ortho‐metallated ligand.
Core‐Shell Catalyst Pellets for CO2 Methanation in a Pilot‐Scale Fixed‐Bed Reactor
Authors: Geschke Alexander , Zimmermann Ronny Tobias , Bremer Jens , Sundmacher Kai 
Published: November 2024

AbstractPower‐to‐methane (PtM) offers an efficient opportunity for surplus renewable energy storage, but heat management is a major challenge for conducting the highly exothermic methanation reaction. To address this challenge, this study presents the first successful demonstration of core‐shell catalyst pellets in a pilot‐scale reactor for CO2 methanation. Experiments in a wall‐cooled fixed‐bed reactor are conducted with diluted and undiluted reactant feed under systematic variation of cooling temperature and inlet gas flow rate. The results show that core‐shell catalyst pellets significantly reduce the hot‐spot temperature while maintaining comparable reactant conversions to uncoated catalyst pellets at the same conditions. Additionally, core‐shell catalyst pellets allow for undiluted reactant feed at comparably low hot‐spot temperatures (approx. 600 °C).
Metal‐Free Nitration of Indazoles with tert‐Butyl Nitrile in Air to Prepare 3‐Nitroindazoles and 3‐Aminoindazoles
Authors: Zhang Xin‐Yue , Jiang Rong‐Ting , Pan Xiu‐Qun , Chen Chun‐Hua , Liang Cui , Mo Dong‐Liang 
Published: November 2024

Comprehensive SummaryA variety of 3‐nitroindazoles and 3‐aminoindazoles were prepared in good to excellent yields with high regioselectivity through TBN‐mediated nitration at the C3‐position of indazoles under the air conditions and sequential reduction. Mechanistic studies revealed that TBN played crucial roles to produce •NO2 radical source in the presence of air conditions and C3‐nitration of indazoles was initiated by N1‐nitration and sequential migration of NO2 group to C3‐position. Moreover, this method could be easily applied in the gram scalable synthesis of ibuprofen and ciprofibrate‐derived 3‐aminoindazoles. The present method highlights air as mild oxidant, metal‐free radical nitration of indazole, N—N bond formation and cleavage, and late‐stage modification of drugs.
Numerical Simulations for Calibration Setup for Dynamic Contrast‐Enhanced Ultrasonography Imaging Protocol
Authors: Marouf Abderahmane , Rahma Ahmed G. , Hoferer Isaline , Girot Charly , Pitre‐Champagnat Stephanie , Hoarau Yannick 
Published: November 2024

ABSTRACTThis study presents an investigation of an innovative microfluidic flow separator using both numerical and experimental approaches to calibrate contrast‐enhanced ultrasound scanners. Numerical simulations were conducted using Lagrangian particles tracking and passive scalar transport methodologies using the OpenFOAM software. The experimental validation confirmed the accuracy of the numerical simulations, particularly at an imposed total pressure of , showing an excellent agreement in particle distributions. The study emphasizes the computational efficiency and modeling of passive scalar transport, providing valuable understanding into the behavior of scalar quantities in microfluidic systems. An optimized diffusion coefficient value of was identified, showing its critical role in achieving accurate simulation results and optimizing the performance of microfluidic flow separators for contrast‐enhanced ultrasound scanner calibration.
Preparation and Growth Mechanism of Pyramid‐Shaped Cu2ZnSnS4 Monocrystal and the Simulation of Its Monograin Layer Solar Cells
Authors: Fu Wenfeng , Zhu Xupeng , Liao Jun , Ru Qiang , Xue Shuwen , Zhang Jun 
Published: November 2024

AbstractThe Cu2ZnSnS4(CZTS) monocrystal as an important component of the optical absorption layer in monograin layer solar cells, has excellent crystallization characteristics and adjustable photogenerated carrier concentration. The shape of the CZTS monocrystal directly affects the utilization of incident light and the contact area during the preparation of the back electrode when they are densely packed to form a single‐layer absorption layer. Herein, a kesterite‐phase pyramid‐shaped CZTS monocrystal prepared by the molten salt method is reported, which can improve the efficiency of incident light utilization and increase the contact area during back electrode preparation. The X‐Ray diffraction, Raman spectroscopy, transmission electron microscopy, and scanning electron microscopy are used to characterize the crystallinity and crystal shape of pyramid‐shaped CZTS monocrystal. Besides, Finite‐Difference simulation calculation is employed to reveal the optical response and corresponding monograin layer solar cells performance of densely packed CZTS. The results show that the pyramid‐shaped structure exhibited excellent incident light trapping ability, and the simulated device achieves a cell efficiency with above 13.6% after parameter optimization. The work provides a method for preparing pyramid‐shaped CZTS monocrystal, and a new strategy to further improve the efficiency of CZTS‐based monograin layer solar cells.
Optimizing fungicide application timing for spring dead spot based on soil temperature and season
Authors: Hutchens W. J. , Booth J. C. , Goatley J. M. , Roberson T. L , McCall D. S. 
Published: November 2024

AbstractSpring dead spot (SDS) (Ophiosphaerella spp.) is the most detrimental disease to warm‐season turfgrasses in areas with cold‐induced dormancy. Fungicide applications do not provide consistent SDS suppression. One reason for this inconsistency is the use of solely calendar‐based fungicide applications instead of considering both calendar date and soil temperature. A field study was conducted at three separate hybrid bermudagrass (Cynodon dactylon (L.) Pers. × transvaalensis Burtt Davy) locations in Virginia to determine the optimal soil temperature and timing for SDS suppression with tebuconazole and isofetamid. Tebuconazole (1.5 kg a.i. ha−1) and isofetamid (4.1 kg a.i. ha−1) were applied at 11 different timings throughout the year based on soil temperatures at a 0‐ to 10‐cm depth. Plots were assessed for SDS severity in the spring and early summer of 2021 and 2022. Two in vitro studies were also conducted with Ophiosphaerella herpotricha and Ophiosphaerella korrae isolates to (1) determine the optimal temperature for growth on potato dextrose agar (PDA) placed on a thermogradient table (13–33°C) and (2) compare the daily growth rate of O. herpotricha and O. korrae isolates at 11, 19, and 27.5°C on PDA. In the field study, isofetamid suppressed SDS more than tebuconazole. Fall applications when soil temperatures were 13°C consistently provided the best SDS suppression. For the in vitro studies, both species grew optimally between 24 and 25°C, yet O. korrae and O. herpotricha growth rates differed at 11°C.
Effective Stabilization of Organic Cathodes Through Formation of a Protective Solid Electrolyte Interface Layer via Reduction
Authors: Wang Yonglin , Huang Zhe , Gao Xiguang , Fazaeli Razieh , Li Yuning 
Published: November 2024

AbstractOrganic electrode materials offer a promising alternative for lithium‐ion batteries due to their lower costs, reduced environmental impact, renewability, and high theoretical capacity. Among them, 2,5‐dihydroxy‐1,4‐benzoquinone (DHBQ) is a promising cathode material, but its high solubility in electrolytes leads to rapid capacity degradation of the battery. This study investigates the dilithium salt of DHBQ, Li2DHBQ, as a cathode material for LIBs. Despite its minimal solubility in the electrolyte, Li2DHBQ cathodes suffer rapid capacity decay due to severe morphological damage within the voltage range of 1.5–3.0 V. To achieve morphological stabilization, we promoted the formation of a protective solid electrolyte interphase (SEI) layer on Li2DHBQ particles by lowering the discharge cutoff voltage. Cycling the battery with a 0.5 V discharge cutoff voltage achieved the optimal thickness and organic‐rich composition of the SEI layer, leading to significantly improved morphological stability of Li2DHBQ. Consequently, the battery maintained 170 mAh g−1 with a low decay rate of 0.16 % within a voltage range of 0.5–3.0 V after 200 cycles at 500 mA g−1. Furthermore, initial cycling with a discharge cutoff voltage of 0.5 V for 20 cycles to form an SEI layer, followed by cycling at a normal discharge cutoff voltage of 1.5 V, retained an even higher capacity of 187 mAh g−1 after 200 cycles at 500 mA g−1. These are significant improvements compared to the battery cycled only in the normal range of 1.5–3.0 V, which retained a capacity of 87 mAh g−1. This study demonstrates the effectiveness of forming a cathode SEI layer at low discharge voltages as a new approach to stabilizing organic cathode materials.
Amino Acid‐Based Ionic Liquids‐Aided CO2 Hydrogenation to Methanol
Authors: Moazezbarabadi Ayeshe , Kammer Anja , Alberico Elisabetta , Junge Henrik , Beller Matthias 
Published: November 2024

AbstractThis study explored the use of amino acid‐based ionic liquids to facilitate the conversion of carbon dioxide (CO2) into methanol through catalytic hydrogenation. Combining tetrabutylammonium L‐argininate (TBA⋅Arg) with the ruthenium Ru‐MACHO‐BH complex allowed achieving significant yields of methanol under optimized conditions, with a turnover number (TON) up to 700. By systematically varying key reaction parameters, we demonstrated that the TBA⋅Arg ionic liquid promotes the efficient hydrogenation pathway leading to methanol formation, thus offering a sustainable approach to CO2 valorization. These findings underscore the potential of amino acid‐based ionic liquids in catalyzing the transformation of CO2 into valuable chemicals, contributing to carbon mitigation efforts.
Associations Between Gender Diversity and Eating Disorder Symptoms in Early Adolescence
Authors: Nagata Jason M. , Li Karen , Kim Angela E. , Shao Iris Yuefan , Otmar Christopher D. , Ganson Kyle T. , Testa Alexander , He Jinbo , Kiss Orsolya , Lavender Jason M. , Baker Fiona C. 
Published: November 2024

ABSTRACTObjectiveTo assess associations between multiple dimensions of gender diversity with eating disorder symptoms in a national cohort of U.S. early adolescents.MethodThis cross‐sectional study utilized data from the Adolescent Brain Cognitive Development (ABCD) Study (N = 10,092, M

age
= 12.9 years, 2019–2021). Gender diversity was measured using multiple dimensions, including categorical gender identity (e.g., transgender, cisgender), categorical and continuous felt gender (congruence between gender identity and assigned sex), ordinal gender non‐contentedness (dissatisfaction with one's gender), and ordinal gender expression (communication of gender through appearance and mannerisms). Multivariable logistic regression models were used to analyze the associations among gender diversity measures and eating disorder symptoms, adjusting for potential confounders.ResultsGreater felt gender diversity was associated with self‐worth tied to weight (OR 1.30, 95% CI 1.11–1.53), binge eating (OR 1.24, 95% CI 1.06–1.46), and distress with binge eating (OR 1.32, 95% CI 1.09–1.59). Greater gender expression diversity was associated with self‐worth tied to weight (OR 1.16, 95% CI 1.02–1.33), distress with binge eating (OR 1.26, 95% CI 1.04–1.51), and characteristics of binge eating episodes (OR 1.33, 95% CI 1.06–1.66). Gender non‐contentedness was associated with self‐worth tied to weight (OR 1.38, 95% CI 1.20–1.58) and compensatory behaviors related to weight gain (OR 1.12, 95% CI 1.01–1.26). Transgender identity was not significantly associated with any eating disorder symptoms.DiscussionWe found that greater gender diversity across multiple dimensions was associated with various eating disorder symptoms, and that measures beyond binary gender identity may be important to assess gender diversity in early adolescence.
Interface triboelectricity
Authors: You Jing , Shao Jiajia , He Yahua , Sun Bobo , See Khay Wai , Wang Zhong Lin , Wang Xiaolin 
Published: November 2024

AbstractThe exploration of triboelectricity at the liquid–solid (L‐S) interface has sparked significant interest due to its potential for sustainable energy harvesting and technological advancement. Motivated by the need for innovative energy solutions and the unique advantages offered by liquid‐based environments, a comprehensive review of the fundamental concepts, mechanisms, and applications of liquid–solid triboelectric nanogenerators (TENGs) is provided. Three basic working modes of liquid–solid TENGs and the distinct properties and mechanisms of each model are discussed systematically. The physical fundamental of liquid–solid TENGs is further investigated, which includes “Wang Transition”, Wang's Hybrid Electric Double Layer model, tribovoltaic effect, equivalent circuit model, and the mechanisms of liquid–solid contact electrification based on density functional theory. Understanding charge transfer and charge distribution at the liquid–solid interface is also crucial to confirm the underlying mechanisms of liquid–solid TENGs. Finally, a broad range of applications of liquid–solid TENGs are explored, emphasizing their potential in addressing energy challenges and complex interdisciplinary issues that link the disciplines of materials science, chemistry, physics, and even electrical engineering.
Substantial Insect Herbivory in a South African Savanna‐Forest Mosaic: A Neglected Topic
Authors: Maraia Heveakore , Charles‐Dominique Tristan , Tomlinson Kyle W. , Staver Ann Carla , Jorge Leonardo Re , Gélin Uriel , Jancuchova‐Laskova Jitka , Sam Legi , Hattas Dawood , Freiberga Inga , Sam Katerina 
Published: November 2024

ABSTRACTInsect herbivory plays a crucial role in shaping plant communities in many terrestrial ecosystems. However, in African savannas, insect herbivory has been relatively understudied compared to large mammalian herbivory. In this study, we examined the impact of insect herbivory, focusing on leaf chewers and miners, in a South African savanna‐forest mosaic (including patches of forest, thicket and savanna) in Hluhluwe iMfolozi Park, South Africa. Our investigation spanned gradients of rainfall, fire frequency and mammal density. We surveyed a total of 864 woody plants from 48 plant species in 38 plots. Insects consumed 6% of leaf biomass, which is comparable to their impact in temperate broadleaf forests, but the extent of herbivory damage varied between vegetation types. Overall, leaf loss was 70% higher in forests and savanna than that in thicket. Plants in the forests experienced greater damage from chewing insects, whereas miners caused relatively more damage in savannas. Rates of insect herbivory also varied among plant species, declining with carbon and dry matter content but increasing with specific leaf area. Although no significant trade‐off was detected between insect and mammal herbivory, plant species with limited physical defences against mammals tended to experience high levels of insect herbivory. Our findings highlight the intricate dynamics of insect herbivory in different vegetation types and suggest that insect leaf herbivory, alongside mammalian herbivory, could play a significant role in influencing plant community composition and overall savanna ecosystem functioning.
Fabulous but Forgotten Fucoid Forests
Authors: Thomsen Mads S. , Stæhr Peter A. U. , South Paul M. 
Published: November 2024

ABSTRACTFucoid forests are areas dominated by marine brown seaweed in the taxonomic order Fucales that, like the better‐known marine foundation species—corals, kelps, seagrasses, salt marshes, and mangroves—are threatened by anthropogenic stressors. Fucoid forests are fabulous and important because they, like the better‐known marine foundation species (i) span large areas, bioregions, and ecosystems, (ii) provide ecological functions such as high productivity, biodiversity, and habitat for iconic and endemic species, and (iii) support a variety of ecosystem services, like commercial fisheries, regulation of nutrients and carbon, and cultural values. Fucoid forests are, based on a new citation analysis, forgotten worldwide, because they are described orders of magnitude less than the better‐known marine foundation species, in ecology and marine biology textbooks, in Google Scholar and Scopus databases over scientific literature, and in recent reports and reviews about seaweed forests. Fucoid forests would be less forgotten if more people acknowledge their biological importance and societal value more often and equate their importance to that of the better‐known marine foundation species. To decrease the knowledge gap between fucoids and the better‐known foundation species, researchers and science communicators could join forces under a broad “fucoid umbrella,” establish stronger online presences, coordinate and collaborate on publications, and produce free eye‐catching non‐technical materials for teachers, managers, politicians, grass‐root organizations, philanthropists, and funding agencies.
eDNA Metabarcoding Analysis of Bony Fish Identification in Coastal Water of Gulf of Maine Using Nested Polymerase Chain Reaction of 12S rRNA Universal Primers
Authors: Lee Bo‐Young , Milne Grant A. , Freedman Corwin , Miksis‐Olds Jenifer , Brown Bonnie L. 
Published: November 2024

ABSTRACTEcosystems in coastal waters of Gulf of Maine (GOM) are undergoing environmental challenges in response to climate change and anthropogenic stressors. eDNA metabarcoding, a powerful tool for assessing the fish community structure, was used to identify fish communities in three types of GOM aquatic environments (sand, macroalgae, and eelgrass) in Maine and New Hampshire, USA. The available 12S rRNA fish universal primer analysis system (MiFish and 12S‐V5) was modified using nested polymerase chain reaction (PCR) to improve targeting of fish products and reduce non‐target products. The nested PCR strategy allowed successful amplification of 12S rRNA genes in fishes without production of non‐target products and identified 28 fish groups at the genus level. Presence/Absence data and Relative Abundance showed significant differences among locales but not among habitats. Myoxocephalus sp. were found at all sampling sites. Relative Abundance data revealed that Menidia menidia and Brevoortia sp. were statistical indicator species in Goosefare, Maine, and New castle, New Hampshire, respectively. Although beta diversity indicated that fish communities were not different across habitats, statistical analysis found that Pholis sp. and Ammodytes sp. were dominant species in macroalgae and sand, respectively. To our knowledge, this is the first metabarcoding study to assess fish communities in the Western Atlantic region using the MiFish primer set, and the study suggests that metabarcoding is useful for mapping geographic and temporal marine fish diversity.