bluuebunny/crossref_metadata_2025_split huggingface dataset:
Lower body ischaemic time is a risk factor for acute kidney injury after surgery for type A acute aortic dissection
Authors: Amano Kentaro , Takami Yoshiyuki , Ishikawa Hiroshi , Ishida Michiko , Tochii Masato , Akita Kiyotoshi , Sakurai Yusuke , Noda Mika , Takagi Yasushi 
Published: August 2019

Abstract

OBJECTIVES
Postoperative acute kidney injury (AKI) is known as a risk factor for death after surgery for Stanford type A acute aortic dissection under hypothermic circulatory arrest. It may also adversely affect long-term survival. We searched for modifiable risk factors for postoperative AKI, focusing on lower body ischaemic time.

METHODS
We reviewed 191 patients undergoing surgical repair for Stanford type A acute aortic dissection. The distal anastomosis depended on excluding the primary tear location, resulting in ascending/hemiarch (n = 119), partial arch (n = 18) and total arch replacement (n = 54). We defined an increase in the serum creatinine level to ≧2 times the baseline level as AKI. The incidence of AKI was investigated with multivariate analysis of its risk factors.

RESULTS
Postoperative AKI was observed in 49 patients (26%), 31% of whom required renal replacement therapy. The overall hospital mortality rate was 8.5%. Postoperative AKI, preoperative shock and organ malperfusion were predictors of hospital death. Multivariate stepwise logistic regression analysis identified age, body mass index, preoperative chronic kidney disease and lower body ischaemic time as risk factors for postoperative AKI.

CONCLUSIONS
Although surgical repair for Stanford type A acute aortic dissection showed favourable results, the incidence of postoperative AKI is still high, closely associated with hospital death. Lower body ischaemic time should be recognized specifically as a modifiable surgical risk factor for postoperative AKI.
Surgical correction of a pulmonary artery aneurysm with severe pulmonary regurgitation with a valve-sparing technique
Authors: Carino Davide , Mehta Nikita , Fernández-Cisneros Alejandro , Pereda Daniel 
Published: August 2019

Abstract
Pulmonary artery aneurysms are rare but are associated with a significant risk of rupture and dissection. Moreover, pulmonary valve regurgitation and/or stenosis often coexist. In this study, we present a case of a pulmonary artery aneurysm with severe pulmonary regurgitation in a patient with pulmonary hypertension treated with aneurysm resection and pulmonary valve repair.
Complexity of Strong Approximation on the Sphere
Authors: T Sardari Naser 
Published: August 2019

AbstractBy assuming some widely believed arithmetic conjectures, we show that the task of accepting a number that is representable as a sum of $d\geq 2$ squares subjected to given congruence conditions is NP-complete. On the other hand, we develop and implement a deterministic polynomial-time algorithm that represents a number as a sum of four squares with some restricted congruence conditions, by assuming a polynomial-time algorithm for factoring integers and Conjecture 1.1. As an application, we develop and implement a deterministic polynomial-time algorithm for navigating Lubotzky, Phillips, Sarnak (LPS) Ramanujan graphs, under the same assumptions.
Mining social media for prescription medication abuse monitoring: a review and proposal for a data-centric framework
Authors: Sarker Abeed , DeRoos Annika , Perrone Jeanmarie 
Published: August 2019

Abstract

Objective
Prescription medication (PM) misuse and abuse is a major health problem globally, and a number of recent studies have focused on exploring social media as a resource for monitoring nonmedical PM use. Our objectives are to present a methodological review of social media–based PM abuse or misuse monitoring studies, and to propose a potential generalizable, data-centric processing pipeline for the curation of data from this resource.

Materials and Methods
We identified studies involving social media, PMs, and misuse or abuse (inclusion criteria) from Medline, Embase, Scopus, Web of Science, and Google Scholar. We categorized studies based on multiple characteristics including but not limited to data size; social media source(s); medications studied; and primary objectives, methods, and findings.

Results
A total of 39 studies met our inclusion criteria, with 31 (∼79.5%) published since 2015. Twitter has been the most popular resource, with Reddit and Instagram gaining popularity recently. Early studies focused mostly on manual, qualitative analyses, with a growing trend toward the use of data-centric methods involving natural language processing and machine learning.

Discussion
There is a paucity of standardized, data-centric frameworks for curating social media data for task-specific analyses and near real-time surveillance of nonmedical PM use. Many existing studies do not quantify human agreements for manual annotation tasks or take into account the presence of noise in data.

Conclusion
The development of reproducible and standardized data-centric frameworks that build on the current state-of-the-art methods in data and text mining may enable effective utilization of social media data for understanding and monitoring nonmedical PM use.
Traditional Chinese medicine clinical records classification with BERT and domain specific corpora
Authors: Yao Liang , Jin Zhe , Mao Chengsheng , Zhang Yin , Luo Yuan 
Published: August 2019

Abstract
Traditional Chinese Medicine (TCM) has been developed for several thousand years and plays a significant role in health care for Chinese people. This paper studies the problem of classifying TCM clinical records into 5 main disease categories in TCM. We explored a number of state-of-the-art deep learning models and found that the recent Bidirectional Encoder Representations from Transformers can achieve better results than other deep learning models and other state-of-the-art methods. We further utilized an unlabeled clinical corpus to fine-tune the BERT language model before training the text classifier. The method only uses Chinese characters in clinical text as input without preprocessing or feature engineering. We evaluated deep learning models and traditional text classifiers on a benchmark data set. Our method achieves a state-of-the-art accuracy 89.39% ± 0.35%, Macro F1 score 88.64% ± 0.40% and Micro F1 score 89.39% ± 0.35%. We also visualized attention weights in our method, which can reveal indicative characters in clinical text.
Relationships between body reserve dynamics and rearing performances in meat ewes1
Authors: Macé Tiphaine , Hazard Dominique , Carrière Fabien , Douls Sebastien , Foulquié Didier , González-García Eliel 
Published: August 2019

AbstractThe main objective of this work was to study the relationships between body reserve (BR) dynamics and rearing performance (PERF) traits in ewes from a Romane meat sheep flock managed extensively on “Causse” rangelands in the south of France. Flock records were used to generate data sets covering 14 lambing years (YR). The data set included 1,146 ewes with 2 ages of first lambing (AGE), 3 parities (PAR), and 4 litter sizes (LS). Repeated measurements of the BW and BCS were used as indicators of BR. The ewe PERF traits recorded were indirect measurements for maternal abilities and included prolificacy, litter weight and lamb BW at lambing and weaning, ADG at 1, 2, and 3 mo after lambing, and litter survival from lambing to weaning. The effects of different BW and BCS trajectories (e.g., changes in BW and BCS across the production cycle), previously been characterized in the same animals, on PERF traits were investigated. Such trajectories reflected different profiles at the intraflock level in the dynamics of BR mobilization–accretion cycles. Genetic relationships between BR and PERF traits were assessed. All the fixed variables considered (i.e., YR, AGE, PAR, LS, and SEX ratio of the litter) have significant effects on the PERF traits. Similarly, BW trajectories had an effect on the PERF traits across the 3 PARs studied, particularly during the first cycle (PAR 1). The BCS trajectories only affected prolificacy, lamb BW at birth, and litter survival. Most of the PERF traits considered here showed moderate heritabilities (0.17–0.23) except for prolificacy, the lamb growth rate during the third month and litter survival which showed very low heritabilities. With exception of litter survival and prolificacy, ewe PERF traits were genetically, strongly, and positively correlated with BW whatever the physiological stage. A few weak genetic correlations were found between BCS and PERF traits. As illustrated by BW and BCS changes over time, favorable genetic correlations were found, even if few and moderate, between BR accretion or mobilization and PERF traits, particularly for prolificacy and litter weight at birth. In conclusion, our results show significant relationships between BR dynamics and PERF traits in ewes, which could be considered in future sheep selection programs aiming to improve robustness.
Dietary addition of garlic straw improved the intestinal barrier in rabbits1
Authors: Liu Lei , Zhao Xiaoyu , Liu Yongxu , Zhao Hong , Li Fuchang 
Published: August 2019

Abstract
Weanling rabbits frequently exhibit diarrhea or flatulence. Our experiment was conducted to investigate the effect of garlic straw on the performance and intestinal barrier of rabbits. Hyla rabbits (60 d, n = 160) with similar body weight were divided into 4 groups (4 replicates per group and 10 rabbits per replicate): fed a basal diet (control) or fed an experimental diet with 5%, 10%, or 15% garlic straw powder supplement. The results showed that the dietary addition of garlic straw increased significantly the average daily gain and average daily feed intake. Compared with the control, dietary addition of 10% and 15% garlic straw decreased significantly the death rate of rabbit. Rabbits in 10% garlic straw group had a higher secretory immunoglobulins A and immunoglobulins G concentration in jejunum and ileum than control while lower tumor necrosis factor α (TNFα) concentration in jejunum. Compared with the control, dietary addition of 10% garlic straw increased significantly genes expression of zonula occluden protein 2 (ZO2) in jejunum and ileum and mucin4 in ileum while did not alter the genes expression of junctional adhesion molecule 2 (JAM2), JAM3, ZO1, occluding, claudin1, mucin1, mucin6, and toll-like receptor 4 in jejunum and ileum and mucin4 in jejunum. In conclusion, dietary supplement of garlic straw modulates immune responses and enhances intestinal barrier, meanwhile inhibits the synthesis of pro-inflammatory cytokine of TNFα. Besides, our experiment offers positive evidence in improving rabbit health of garlic instead of antibiotics.
Urinary Pharmacokinetic Profile of Cannabinoids Following Administration of Vaporized and Oral Cannabidiol and Vaporized CBD-Dominant Cannabis
Authors: Spindle Tory R , Cone Edward J , Kuntz David , Mitchell John M , Bigelow George E , Flegel Ronald , Vandrey Ryan 
Published: August 2019

Abstract
Cannabis products in which cannabidiol (CBD) is the primary chemical constituent (CBD-dominant) are increasingly popular and widely available. The impact of CBD exposure on urine drug testing has not been well studied. This study characterized the urinary pharmacokinetic profile of 100-mg oral and vaporized CBD, vaporized CBD-dominant cannabis (100-mg CBD; 3.7-mg ∆9-THC) and placebo in healthy adults (n = 6) using a within-subjects crossover design. Urine specimens were collected before and for 5 days after drug administration. Immunoassay (IA) screening (cutoffs of 20, 50 and 100 ng/mL) and LC–MS-MS confirmatory tests (cutoff of 15 ng/mL) for 11-nor-9-carboxy-∆9-tetrahydrocannabinol (∆9-THCCOOH) were performed; urine was also analyzed for CBD and other cannabinoids. Urinary concentrations of CBD were higher after oral (mean Cmax: 776 ng/mL) versus vaporized CBD (mean Cmax: 261 ng/mL). CBD concentrations peaked 5 h after oral CBD ingestion and within 1 h after inhalation of vaporized CBD. After pure CBD administration, only 1 out of 218 urine specimens screened positive for ∆9-THCCOOH (20-ng/mL IA cutoff) and no specimens exceeded the 15-ng/mL confirmatory cutoff. After inhalation of CBD-dominant cannabis vapor, nine samples screened positive at the 20-ng/mL IA cutoff, and two of those samples screened positive at the 50-ng/mL IA cutoff. Four samples that screened positive (two at 20 ng/mL and two at 50 ng/mL) confirmed positive with concentrations of ∆9-THCCOOH exceeding 15 ng/mL. These data indicate that acute dosing of pure CBD will not result in a positive urine drug test using current federal workplace drug testing guidelines (50-ng/mL IA cutoff with 15-ng/mL confirmatory cutoff). However, CBD products that also contain ∆9-THC may produce positive urine results for ∆9-THCCOOH. Accurate labeling and regulation of ∆9-THC content in CBD/hemp products are needed to prevent unexpected positive drug tests and unintended drug effects.
Season-Long Monitoring of the Brown Marmorated Stink Bug (Hemiptera: Pentatomidae) Throughout the United States Using Commercially Available Traps and Lures
Authors: Acebes-Doria Angelita L , Agnello Arthur M , Alston Diane G , Andrews Heather , Beers Elizabeth H , Bergh J Christopher , Bessin Ric , Blaauw Brett R , Buntin G David , Burkness Eric C , Chen Shi , Cottrell Ted E , Daane Kent M , Fann Lauren E , Fleischer Shelby J , Guédot Christelle , Gut Larry J , Hamilton George C , Hilton Richard , Hoelmer Kim A , Hutchison William D , Jentsch Peter , Krawczyk Greg , Kuhar Thomas P , Lee Jana C , Milnes Joshua M , Nielsen Anne L , Patel Dilani K , Short Brent D , Sial Ashfaq A , Spears Lori R , Tatman Kathy , Toews Michael D , Walgenbach James D , Welty Celeste , Wiman Nik G , Van Zoeren Janet , Leskey Tracy C 
Published: August 2019

Abstract
Reliable monitoring of the invasive Halyomorpha halys abundance, phenology and geographic distribution is critical for its management. Halyomorpha halys adult and nymphal captures on clear sticky traps and in black pyramid traps were compared in 18 states across the Great Lakes, Mid-Atlantic, Southeast, Pacific Northwest and Western regions of the United States. Traps were baited with commercial lures containing the H. halys pheromone and synergist, and deployed at field sites bordering agricultural or urban locations with H. halys host plants. Nymphal and adult captures in pyramid traps were greater than those on sticky traps, but captures were positively correlated between the two trap types within each region and during the early-, mid- and late season across all sites. Sites were further classified as having a low, moderate or high relative H. halys density and again showed positive correlations between captures for the two trap types for nymphs and adults. Among regions, the greatest adult captures were recorded in the Southeast and Mid-Atlantic on pyramid and sticky traps, respectively, with lowest captures recorded in the West. Nymphal captures, while lower than adult captures, were greatest in the Southeast and lowest in the West. Nymphal and adult captures were, generally, greatest during July–August and September–October, respectively. Trapping data were compared with available phenological models showing comparable population peaks at most locations. Results demonstrated that sticky traps offer a simpler alternative to pyramid traps, but both can be reliable tools to monitor H. halys in different geographical locations with varying population densities throughout the season.
Identification and Genetic Differentiation of Sitobion avenae (Hemiptera: Aphididae) Biotypes in China
Authors: Wang Da , Zhai Yingting , Liu Deguang , Zhang Na , Li Chunbo , Shi Xiaoqin 
Published: August 2019

Abstract
The development of biotypes of the cereal aphid, Sitobion avenae (Fabricius) (Hemiptera: Aphididae), was initially found only on wheat, but barley can also be critical in the process. To address this issue, S. avenae clones were collected on barley and wheat, genotyped with six microsatellite markers, and tested with 58 wheat/barley varieties. Based on the virulence response profiles on different resistant wheat/barley varieties and three susceptible controls, six biotypes of S. avenae were identified. We developed a new system to distinguish between S. avenae biotypes by using only five barley/wheat varieties (i.e., barley: Dulihuang, Zaoshu No.3, Xiyin No.2; wheat: Zhong 4 wumang, 186-TM12-34). The unique virulence profiles of different S. avenae biotypes were further verified by testing their life-history traits (i.e., 10-d fecundity and total developmental time of nymphs) on the abovementioned five barley/wheat varieties. Among all the identified biotypes, biotype 1 was predominant, occupying over 82% of the total in each province. Biotype 5 was found only in Xinjiang, whereas biotype 6 occurred only in Zhejiang. The principal coordinate analysis with microsatellite data suggested apparently low genetic differentiation between biotypes 1 and 2. In most cases, extents of genetic divergence between different S. avenae biotypes could reflect differences in virulence response profiles of these biotypes, implying a genetic component for evolutionary relationships among these biotypes. Our study provides insights into the development and evolution of aphid biotypes, and a firm basis for clarifying the underlying genetic and evolutionary mechanisms.
Exploring the Efficacy and Mechanisms of a Crop Sterilant for Reducing Infestation by Spotted-Wing Drosophila (Diptera: Drosophilidae)
Authors: Van Timmeren Steven , Fanning Philip D , Schöneberg Torsten , Hamby Kelly , Lee Jana , Isaacs Rufus 
Published: August 2019

AbstractVinegar flies (Diptera: Drosophilidae) are well known to be associated with yeasts, which provide important nutrients and emit attractive semiochemicals. Drosophila suzukii (Matsumura) has become a major pest of berries and cherries around the world, requiring intensive management to maintain fruit quality. Although insecticides remain a dominant control approach, disruption of fly–yeast–host interactions remains a promising avenue for reducing the economic impact of this pest. We conducted field and laboratory experiments to explore whether a crop sterilant (peroxyacetic acid and hydrogen peroxide) developed for disease control can affect D. suzukii. In 2 yr of field tests in highbush blueberries, we found significantly lower infestation by D. suzukii in plots treated with the crop sterilant, both alone and in a rotation program with zeta-cypermethrin. When shoots from treated plots were tested in no-choice bioassays, crop sterilant treatments did not affect adult mortality or oviposition, but they reduced infestation. To explore the mechanisms in the laboratory, we found that the crop sterilant did not affect adult mortality, nor oviposition on treated fruit under no-choice settings, but adult flies settled and oviposited less on treated fruit in choice settings. When the crop sterilant was applied to colonies of Hanseniaspora uvarum (Niehaus) (Saccharomycetales: Saccharomycodaceae) and Issatchenkia terricola (Van der Walt) (Saccharomycetales: Saccharomycetacea) yeasts that are attractive and provide nutrition to D. suzukii, there was a dose-dependent inhibition of their growth. We highlight the potential for microbial management as a component of integrated pest management programs and prioritize research needs to incorporate this approach into control programs.
Landscape-scale effects of homesteads, water, and dingoes on invading chital deer in Australia’s dry tropics
Authors: Forsyth David M , Pople Anthony , Woodford Luke , Brennan Michael , Amos Matt , Moloney Paul D , Fanson Ben , Story Georgeanna 
Published: August 2019

AbstractIdentifying landscape features and processes that facilitate the persistence of populations is particularly important for invasive mammal species, because it can focus management interventions on relatively small areas. We used camera traps to test predictions concerning the relative abundance of invading chital deer (Axis axis) on seven cattle ranches in northern Australia: that abundance of chital deer would be highest near permanent water and near homesteads, and that dingoes (Canis dingo) reduce abundance of chital deer. Distance from the nearest homestead determined deer abundance (as indexed by images per camera-day), with negligible abundance > 4 km from homesteads. In contrast, distance from homestead did not predict abundance of feral pigs (Sus scrofa), macropods, or dingoes. Abundance of chital deer also declined with increasing distance from water, as did feral pig abundance. There was no relationship between either macropod or dingo abundance and distance to water. The abundance of chital deer was unaffected by dingo abundance, but 75–100% of dingo scats collected within 1 km of homesteads contained chital deer. The high abundances of chital deer near homesteads are likely due to increased food quality or quantity, or protection from dingoes, but these hypotheses require further testing. We conclude that homesteads and permanent water are important determinants of the distribution and abundance of invasive chital deer in northern Australia (i.e., they are “invasion hubs” for this species). Our results suggest that, during the dry season, managers should survey for and attempt to control chital deer within 4 km of homesteads and within 3 km of water.
Formation of root silica aggregates in sorghum is an active process of the endodermis
Authors: Soukup Milan , Rodriguez Zancajo Victor M , Kneipp Janina , Elbaum Rivka 
Published: August 2019

Abstract
Silica deposition in plants is a common phenomenon that correlates with plant tolerance to various stresses. Deposition occurs mostly in cell walls, but its mechanism is unclear. Here we show that metabolic processes control the formation of silica aggregates in roots of sorghum (Sorghum bicolor L.), a model plant for silicification. Silica formation was followed in intact roots and root segments of seedlings. Root segments were treated to enhance or suppress cell wall biosynthesis. The composition of endodermal cell walls was analysed by Raman microspectroscopy, scanning electron microscopy and energy-dispersive X-ray analysis. Our results were compared with in vitro reactions simulating lignin and silica polymerization. Silica aggregates formed only in live endodermal cells that were metabolically active. Silicic acid was deposited in vitro as silica onto freshly polymerized coniferyl alcohol, simulating G-lignin, but not onto coniferyl alcohol or ferulic acid monomers. Our results show that root silica aggregates form under tight regulation by endodermal cells, independently of the transpiration stream. We raise the hypothesis that the location and extent of silicification are primed by the chemistry and structure of polymerizing lignin as it cross-links to the wall.