bluuebunny/crossref_metadata_2025_split huggingface dataset:
Television's Mixed Messages: Choose the Best and Mute the Rest (The Sequel)
Authors: Schreck Kimberly A. , Lyon Jonathan , Leslie Julia , Wilson Samara 
Published: December 2024

ABSTRACTMedia's framing of autism treatment practices may significantly impact parents' and professionals' choices. This study examined the trends of media's framing of evidence‐based practices (EBP) and non‐evidence‐based practices (NEBP) within television transcripts (n = 203) comparing previously published transcript data from 2000 to 2012 and new data from the subsequent decade (i.e., 2013–2022). Results indicated that EBPs received less overall television coverage than NEBPs. However, applied behavior analysis remained the most mentioned EBP. Although television networks framed NEBPs negatively, these treatment practices also received proportionately more positive statements than EBPs. Based on these results, behavior analysts must continue to disseminate to journalists and to influence media framing of EBPs for autism. If not, these continuing television media framing trends could result in potential harm to autistic individuals.
Green/red fluorescent protein disrupting drugs for real‐time permeability tracking in three‐dimensional tumor spheroids
Authors: Avrashami Maytal , Niezni Danna , Meron Azagury Dana , Sason Hagit , Shamay Yosi 
Published: December 2024

AbstractThree‐dimensional (3D) spheroid models offer a more physiologically relevant and complex environment compared to traditional two‐dimensional cultures, making them a promising tool for studying tumor biology and drug response. However, these models often face challenges in real‐time monitoring of drug diffusion, penetration, and target engagement, limiting their predictive power for in vivo and clinical outcomes. This study introduces a novel approach for real‐time tracking of drug permeability using small molecule drugs with GFP/RFP‐disrupting properties that correlate with their efficacy. We developed a reproducible 3D spheroid model with various cancer cell lines expressing GFP/RFP for efficient drug screening. Through screening over 20 FDA‐approved enzyme inhibitors, we identified three covalent kinase inhibitors—osimertinib, afatinib, and neratinib—that irreversibly disrupt GFP and RFP fluorescence. Our results reveal distinct drug diffusion and penetration profiles within GFP/RFP‐expressing spheroids, varying with drug concentration and formulation, and correlating with clinical volume of distribution (Vd) values. Additionally, we demonstrate that our approach is useful for evaluating different drug formulations as well as screening penetration enhancers for solid tumors. These findings offer a valuable 3D model for studying kinetics of drug permeability and efficacy in tumor‐like environments, with potential implications for drug delivery research and formulation development.
Analysis and Design of Stacked Coupled Inductor Quadratic Boost Converter With a Lossless Snubber Cell
Authors: Koç Yavuz , Birbir Yaşar , Özel Erdoğan 
Published: December 2024

ABSTRACTThis paper introduces the stacked coupled inductor quadratic boost converter with an inductorless, passive lossless snubber cell suited for high step‐up applications with various microgrids. Some design constraints can be selected from the voltage gain techniques of the high step‐up converters to obtain the solution of improvement performance of converter. The proposed converter utilizes quadratic boost converter and coupled inductor to attain high voltage gain beyond the voltage multiplier/lift cells. In this proposed converter, the use of a stacked coupled inductor type introduces the leakage inductor to snubber cell as an inductor without using an extra inductor in proposed snubber cell. Thus, a regenerative snubber cell is used to achieve a high system efficiency. Compared with earlier counterparts, the solution of attaining a high voltage gain in the proposed converter and passive lossless snubber cell leads to an increase in the converter's performance, reliability, and robustness. The theoretical expectations are supported by simulations and verified by experimental results obtained by implementing a 300‐V, 120‐W prototype.
Review on pathogenesis and treatment of Alzheimer's disease
Authors: Cai Jinxia , Liu Yanqing , Fan Haojun 
Published: December 2024

AbstractThe rising incidence of Alzheimer's disease (AD) and the associated economic impacts has prompted a global focus in the field. In recent years, there has been a growing understanding of the pathogenic mechanisms of AD, including the aggregation of β‐amyloid, hyperphosphorylated tau, and neuroinflammation. These processes collectively lead to neurodegeneration and cognitive decline, which ultimately results in the loss of autonomy in patients. Currently, there are three main types of AD treatments: clinical tools, pharmacological treatment, and material interventions. This review provides a comprehensive analysis of the underlying etiology and pathogenesis of AD, as well as an overview of the current prevalence of AD treatments. We believe this article can help deepen our understanding of the AD mechanism, and facilitate the clinical translation of scientific research or therapies, to address this global problem of AD.
Progress to Develop Globally Harmonized International Testing Standards for Large Outdoor Fires, Including Wildland‐Urban Interface Fires
Authors: Manzello Samuel L. 
Published: December 2024

ABSTRACTThe wildland‐urban interface (WUI) fire problem continues to perplex governments around the world. The WUI fire situation is not becoming better across the earth and globally harmonized test standards are required to help lessen the destruction in the event of WUI fire disasters. In this brief overview, a review of activities undertaken in ISO TC92/WG14, the Large Outdoor Fires and the Built Environment Working Group, under ISO TC92, is provided. Specifically, the genesis of how this working group came to be formed is provided as well as an overview of current documents that have been published by ISO TC92 and developed by ISO TC92/WG14. The review closes with recently added new work items in ISO TC92/WG14 and some possible future challenges.
Vorschlag zur Beschreibung des einaxialen Druckverhaltens von hochverformbaren Dichtwandmassen im Modell der inneren Struktur
Authors: Ramler‐Kowollik Marcel , Quarg‐Vonscheidt Jürgen 
Published: December 2024

AbstractEine Arbeitsgruppe der DWA (Deutsche Vereinigung für Wasserwirtschaft, Abwasser und Abfall e. V.) erarbeitet momentan Empfehlungen für die Planung und die Zusammensetzung von hydraulisch gebundenen, hochverformbaren Dichtwandmassen für den Einsatz im Wasserbau. Ein wichtiges Ziel ist die Ausnutzung des plastischen Materialverhaltens von hochverformbaren Dichtwandmassen. In diesem Kontext soll nachfolgend ein Vorschlag präsentiert werden, das plastische Spannungs‐Verformungsverhalten, speziell im einaxialen Druckversuch, über ein neuartiges „Modell der inneren Struktur“ zu beschreiben. Das „Modell der inneren Struktur“ in dieser Ausprägung greift grundlegende Beschreibungen aus Modellen zur gerichteten Lastweiterleitung anhand konkreter Kontaktorientierungen in trockenen granularen Haufwerken auf, welche speziell in Japan in den 1960er‐ und 1970er‐Jahren entwickelt wurden, und erweitert diese um einen Ansatz zur Berücksichtigung kohäsiver Materialeigenschaften.
Multi Layered Omics Approaches Reveal Glia Specific Alterations in Alzheimer's Disease: A Systematic Review and Future Prospects
Authors: İş Özkan , Min Yuhao , Wang Xue , Oatman Stephanie R. , Abraham Daniel Ann , Ertekin‐Taner Nilüfer 
Published: December 2024

ABSTRACTAlzheimer's disease (AD) is the most common neurodegenerative dementia with multi‐layered complexity in its molecular etiology. Multiple omics‐based approaches, such as genomics, epigenomics, transcriptomics, proteomics, metabolomics, and lipidomics are enabling researchers to dissect this molecular complexity, and to uncover a plethora of alterations yielding insights into the pathophysiology of this disease. These approaches reveal multi‐omics alterations essentially in all cell types of the brain, including glia. In this systematic review, we screen the literature for human studies implementing any omics approach within the last 10 years, to discover AD‐associated molecular perturbations in brain glial cells. The findings from over 200 AD‐related studies are reviewed under four different glial cell categories: microglia, oligodendrocytes, astrocytes and brain vascular cells. Under each category, we summarize the shared and unique molecular alterations identified in glial cells through complementary omics approaches. We discuss the implications of these findings for the development, progression and ultimately treatment of this complex disease as well as directions for future omics studies in glia cells.
Insuring for cyclone events: What matters to small business owners?
Authors: Edobor Edeoba W. , Marshall Maria I. , Katare Bhagyashree , Valdivia Corinne 
Published: December 2024

AbstractUsing a discrete choice experiment, we examined the impact of previous disaster experiences, charity hazard, and temporal orientation on willingness to pay (WTP) for hypothetical cyclone insurance. We found that business owners preferred policies that covered flood, windstorm, and business interruption regardless of the combination. They also preferred shorter waiting periods and higher coverage levels. Respondents who had previously experienced cyclones were more willing to pay for the presented insurance policies than those who had not. Furthermore, future‐orientated owners were more likely to pay for the presented policies, while charity hazard was positively correlated with WTP for government‐provided insurance.
Factors associated with DPP4i or SGLT2i utilisation: a retrospective cohort study among people with type 2 diabetes mellitus
Authors: Sim Ruth , Chong Chun Wie , Loganadan Navin Kumar , Adam Noor Lita , Hussein Zanariah , Lee Shaun Wen Huey 
Published: December 2024

AbstractBackgroundDipeptidyl peptidase‐4 inhibitors (DPP4i) and sodium‐glucose co‐transporter 2 inhibitors (SGLT2i) are increasingly used as glucose‐lowering therapies in Malaysia.AimTo examine factors associated with the initiation of DPP4i or SGLT2i among people with type 2 diabetes mellitus (T2DM) in Malaysia.MethodA retrospective cohort study was conducted from 1 January 2012–30 December 2020 in two tertiary Malaysian hospitals. Multivariate logistic regression was used to assess the factors associated with DPP4i or SGLT2i initiation. The impact of treatment initiation on glycaemic control, anthropometric and lipid levels at 6 and 12 months were also measured. Ethical approval was granted by the Malaysian National Medical Research Register (Reference no: NMRR‐20‐662‐52570), the Monash University Human Research Ethics Committee (Reference no: 2020‐24900‐45575), the Ministry of Health Malaysia Medical Research and Ethics Committee, and the study conforms with the Declaration of Helsinki.ResultsThis study included 1628 patients. Patients with co‐existing dyslipidaemia (odds ratio [OR] 1.34, 95% confidence interval [CI] 1.04–1.73), cardiovascular disease (OR 1.43, 95% CI 1.1–1.87), and microalbuminuria (OR 2.47, 95% CI 1.42–4.3), with ≥5‐year history of T2DM (years of T2DM 5–14 OR 1.67, 95% CI1.18–2.38; years of T2DM ≥15 OR 2.07, 95% CI 1.39–3.07), who had a body weight of ≥100 kg (OR 1.75, 95% CI 1.26–2.45), and baseline use of three or more glucose‐lowering medicines (OR 2.92, 95% CI 1.74–4.91) had higher odds of being prescribed with SGLT2i. Patients aged ≥65 years old (OR 0.68, 95% CI 0.50–0.93), presented with a family history of diabetes (OR 0.64, 95% CI 0.47–0.89), an estimated glomerular filtration rate (eGFR) ≥60 mL/min/1.73 m2 (eGFR 60–89 mL/min/1.73 m2 OR 0.60, 95% CI 0.39–0.90; eGFR ≥90 mL/min/1.73 m2 OR 0.55, 95% CI 0.34–0.87), with serum creatinine ≥120 μmol/L (OR 0.31, 95% CI 0.17–0.58), and had baseline usage of sulfonylureas (OR 0.28, 95% CI 0.19–0.4) and insulin (OR 0.5, 95% CI 0.35–0.72) were more likely to receive DPP4i. Glycated haemoglobin of patients receiving these medicines reduced significantly at 6 months (DPP4i: −0.61%, p < 0.001; SGLT2i: −0.66%, p < 0.001) and 12 months (DPP4i: −0.62%, p < 0.001; SGLT2i: −0.74%, p < 0.001).ConclusionTreatment choice with pharmacotherapy was associated with many clinical risk factors presented by patients.
Consumer attitudes, willingness to pay and hedonic evaluations of innovative legume gnocchi products
Authors: Mustapa Muhammad Adzran Che , Kallas Zein , López‐Mas Laura , Alamprese Cristina , Contiero Silvia , Aguiló‐Aguayo Ingrid 
Published: December 2024

AbstractBACKGROUNDWith growing concerns over the adverse effects of animal‐derived products on health, animal welfare and the environment, the rising popularity of plant‐based foods underscores the importance of understanding consumer preferences and determining acceptance. The present study takes the form of a case study that utilized innovative legume‐based flours to develop multiple gnocchi products. The Becker–DeGroot–Marschak (BDM) mechanism as an auction method was employed to elicit consumers’ willingness to pay (WTP) following a hedonic evaluation test involving 127 Spanish consumers.RESULTSThe findings indicate that a majority of consumers exhibit a high level of environmental concern, coupled with increased trust in, as well as perceptions of, the benefits of consuming plant‐based products. However, they demonstrated moderate attitudes with regard to plant‐based products. Notably, product sample tasting had a negative impact on consumers’ WTP for legume‐based gnocchi. The respondents' education level, income, financial situation, government support, environmental concerns, perceived risks, flavor and color significantly influenced consumers’ WTP.CONCLUSIONThe present study offers initial insights into consumer attitudes and WTP for legume‐based products in Spain. The findings are of relevance for producers and marketers aiming to promote environmentally‐sustainable food production and consumption. They may also play a pivotal role in facilitating the successful introduction and sale of such plant‐based products in the Spanish market. Going forward, addressing any limitations of this study and exploring further research avenues will be crucial for refining our understanding of consumer behavior in this context. © 2024 The Author(s). Journal of the Science of Food and Agriculture published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.
Clinical Effects and Response Time of Biological Drugs in Chronic Rhinosinusitis with Nasal Polyps Patients: Real‐life Experience
Authors: De Santis Sante , Galassi Stefania , Cambi Jacopo 
Published: December 2024

ObjectiveChronic Rhinosinusitis with Nasal Polyps (CRSwNP) is a challenging condition often managed with biologic therapies. This study compares the clinical effects and response times of dupilumab, omalizumab, and mepolizumab in Italian patients with severe uncontrolled CRSwNP.MethodsThis bicentric, retrospective study included 33 patients treated at two Italian hospitals between April and December 2023. Inclusion criteria followed EPOS 2020 guidelines, focusing on adults with bilateral polyposis, history of endoscopic sinus surgery, and evidence of type 2 inflammation. Patients self‐administered biologics according to AIFA protocols. Outcomes were assessed using SNOT‐22 for quality of life, Nasal Polyp Score (NPS) for polyp size, and Sniffin’ Sticks‐12 for olfactory function at baseline, 4 weeks, 3, 6, and 9 months.ResultsAll three treatment groups (dupilumab, omalizumab, mepolizumab) showed significant improvements in SNOT‐22 scores from baseline to 9 months, with no significant differences between groups. Dupilumab showed the most rapid and sustained improvement in NPS, with significant reductions observed from 4 weeks onward. Both omalizumab and mepolizumab showed significant NPS reductions by 6 months. Olfactory function improved significantly in the dupilumab group, with a notable decrease in anosmic patients from 64.3% to 28.6% at 9 months. Asthma control, measured by Asthma Control Test (ACT) scores, improved across all groups.ConclusionDupilumab, omalizumab, and mepolizumab significantly improve quality of life and reduce nasal polyp size in CRSwNP patients, with dupilumab showing the fastest response. These findings support the effectiveness of biologics in real‐world settings for managing severe CRSwNP.Level of Evidence3 Laryngoscope, 2024
An In‐Depth Coho Salmon (Oncorhynchus kisutch) Ovarian Follicle Proteome Reveals Coordinated Changes Across Diverse Cellular Processes during the Transition From Primary to Secondary Growth
Authors: Timmins‐Schiffman Emma , Telish Jennifer , Field Chelsea , Monson Chris , Guzmán José M. , Nunn Brook L. , Young Graham , Forsgren Kristy 
Published: December 2024

ABSTRACTTeleost fishes are a highly diverse, ecologically essential group of aquatic vertebrates that include coho salmon (Oncorhynchus kisutch). Coho are semelparous and all ovarian follicles develop synchronously. Owing to their ubiquitous distribution, teleosts provide critical sources of food worldwide through subsistence, commercial fisheries, and aquaculture. Enhancement of hatchery practices requires detailed knowledge of teleost reproductive physiology. Despite decades of research on teleost reproductive processes, an in‐depth proteome of teleost ovarian development has yet to be generated. We have described a coho salmon ovarian proteome of over 5700 proteins, generated with data independent acquisition, revealing the proteins that change through the transition from primary to secondary ovarian follicle development. This transition is critical during the onset of puberty and for determining egg quality and embryonic development. Primary follicle development was marked by differential abundances of proteins in carbohydrate metabolism, protein turnover, and the complement pathway, suggesting elevated metabolism as the follicles develop through stages of oogenesis. The greatest proteomic shift occurred during the transition from primary to secondary follicle growth, with increased abundance of proteins underlying cortical alveoli formation, extracellular matrix reorganization, iron binding, and cell–cell signaling. This work provides a foundation for identifying biomarkers of salmon oocyte stage and quality.
Anthromes and forest carbon responses to global change
Authors: Hogan J. Aaron , Lichstein Jeremy W. , Helmer Eileen H. , Craig Matthew E. , Fricke Evan , Henrich Viola , Kannenberg Steven A. , Koven Charles D. , Goldewjik Kees Klein , Lapola David M. , Li Yue , Malhi Yadvinder , Quinn John , Roe Stephanie , Terrer Cesar , Vilanova Emilio , Walker Anthony P. , Zhu Kai , Ellis Erle C. 
Published: December 2024

Societal Impact StatementForest ecosystems absorb and store about 25% of global carbon dioxide emissions annually and are increasingly shaped by human land use and management. Climate change interacts with land use and forest dynamics to influence observed carbon stocks and the strength of the land carbon sink. We show that climate change effects on modeled forest land carbon stocks are strongest in tropical wildlands that have limited human influence. Global forest carbon stocks and carbon sink strength may decline as climate change and anthropogenic influences intensify, with wildland tropical forests, especially in Amazonia, likely being especially vulnerable.Summary
Human effects on ecosystems date back thousands of years, and anthropogenic biomes—anthromes—broadly incorporate the effects of human population density and land use on ecosystems. Forests are integral to the global carbon cycle, containing large biomass carbon stocks, yet their responses to land use and climate change are uncertain but critical to informing climate change mitigation strategies, ecosystem management, and Earth system modeling.
Using an anthromes perspective and the site locations from the Global Forest Carbon (ForC) Database, we compare intensively used, cultured, and wildland forest lands in tropical and extratropical regions. We summarize recent past (1900‐present) patterns of land use intensification, and we use a feedback analysis of Earth system models from the Coupled Model Intercomparison Project Phase 6 to estimate the sensitivity of forest carbon stocks to CO2 and temperature change for different anthromes among regions.
Modeled global forest carbon stock responses are positive for CO2 increase but neutral to negative for temperature increase. Across anthromes (intensively used, cultured, and wildland forest areas), modeled forest carbon stock responses of temperate and boreal forests are less variable than those of tropical forests. Tropical wildland forest areas appear especially sensitive to CO2 and temperature change, with the negative temperature response highlighting the potential vulnerability of the globally significant carbon stock in tropical forests.
The net effect of anthropogenic activities—including land‐use intensification and environmental change and their interactions with natural forest dynamics—will shape future forest carbon stock changes. These interactive effects will likely be strongest in tropical wildlands.
Pesticide use in integrated pest and pollinator management framework to protect pollinator health
Authors: Phan Ngoc T , Biddinger David J , Rajotte Edwin G , Smagghe Guy , Reddy Gadi VP , Ren Zong‐Xin , Joshi Neelendra K 
Published: December 2024

AbstractAgricultural pesticides have historically been a critical tool in controlling pests and diseases, preventing widespread suffering and crop losses that led to catastrophes such as the Great Irish Famine (1845–1852) and the Cotton Boll Weevil Infestation (1915–1916). However, their usage has brought challenges, including resistance development, secondary pest outbreaks, harm to non‐target organisms like pollinators, and environmental contamination. In response to these concerns, integrated pest management (IPM) has emerged as a comprehensive approach, emphasizing non‐chemical pest control methods such as cultural practices, biological control, and crop rotation, with pesticides as the last resort. IPM has evolved, influenced by regulations like the Food Quality Protection Act (FQPA), which prioritizes human health protection, especially for children. The development of systemic pesticides, particularly neonicotinoids, introduced a more efficient and targeted pest control method within the IPM framework. However, they have also raised concerns due to their potential adverse effects on pollinators. In recent years, integrated pest and pollinator management (IPPM) has emerged as an enhanced approach, integrating pollinator health considerations into pest management strategies. In this article, we discuss this new approach, and briefly present an example of a modifying pesticide program in Pennsylvania apple orchards to illustrate the application of IPPM, in order to highlight the importance of IPPM in sustaining agriculture, protecting vital pollinators, and maintaining effective pest control practices. © 2024 The Author(s). Pest Management Science published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.