bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of TGP’s compression ratio on the vibration response of PCBA
Authors: Jia Pu 
Published: November 2024

Abstract
The influence of the compression ratio of the thermal conductive pad (TCP) on vibration response characteristics of airborne electronic equipment is investigated. The acceleration and strain in three cases, i.e. with no thermal conductive pad, the compression ratio of 10% and 55%, are studied respectively. The results show that, by using a thermal conductive pad, the acceleration and strain can be reduced significantly. The response of acceleration and strain with different compression ratios are significantly different. A high compression ratio can increase the vibration response. An unreasonable selection of thermal conductive pads can result in high stress in the surroundings of screws and chips, which will lead to component failure.
Uncertainty analysis of hypersonic flight dynamics under elastic effects
Authors: Li Shuqing , Zeng Fanlin , Xiang Qiulin 
Published: November 2024

Abstract
In addressing the aerodynamic-elastic coupling issues of hypersonic vehicles, this study delves into the analysis of the elastic deformation of the aircraft based on mechanistic understanding. It employs the Interval Analysis Method based on Polynomial Approximations to conduct uncertainty analysis of the aerodynamic model under elasticity, delineating the range of uncertainty in the aerodynamic model influenced by elastic deformation. The aerodynamic force of the aircraft under elasticity is connected with the rigid body, and then the aerodynamic layout of the aircraft fuselage and control surface after elastic deformation is calculated to study the influence of the elastic effect on the aerodynamic force. The results show that the change caused by uncertainty has a relatively small effect on lift but a relatively large effect on drag and pitching moment.
Effect of hypergravity on CHF for water flow boiling in a rectangular channel
Authors: Zhang Zhao , Sun Zhi 
Published: November 2024

Abstract
Hypergravity during the maneuver of aircraft can obviously increase the intensity of disturbance in flow boiling. The critical heat flux (CHF) is a critical parameter to prevent the aircraft thermal management system from drying out. On a rotating platform with distilled water as the working fluid, an experimental investigation into the water flow boiling CHF characteristics in a rectangular channel under hypergravity was carried out. In this study, the influence of hypergravity, entry temperature, mass velocity with heating direction on flow boiling CHF have been investigated and discussed. The results show that hypergravity has a clear effect on the CHF by improving two-phase mixing and bubble separation. CHF increases as the hypergravity and mass velocity increase but decreases as the inlet temperature rises. The orientation of the heating has a clear impact on CHF. A new fitting correlation was discovered as a result of the current study.
Simulation and experimental study of aerodynamic characteristics of a rotor adsorption wall-climbing robot
Authors: Cheng Zheng , Song Meili , Liu Yong , Wu Hongbo , Ouyang Haonan 
Published: November 2024

Abstract
High-rise buildings are prone to gusts of wind, especially crosswinds. In order to investigate the effect of crosswinds on the aerodynamic characteristics of rotor blades at different near-wall distances, a CFD simulation model is designed for four near-wall distances and five wind speeds, and the change curves of rotor pulling force, pressure cloud diagrams and velocity cloud diagrams are obtained by using Fluent for the various conditions. The mechanism and pattern of its influence on the aerodynamic characteristics of rotor blades are studied by observing the pulling force change curve and cloud diagram. Finally, an experimental platform is built to verify the correctness of the simulation results. The simulation and experimental results have a similar law, i.e., crosswinds do not only have a negative effect on reducing the pulling force generated by the rotor blades, but can also have a gain effect on the pulling force in some cases. This law has some application value, which can be utilized to compensate the rotor speed accordingly. When the pulling force is reduced, the speed is increased appropriately to improve the reliability of the adsorption, and when the pull force is increased, the speed is reduced appropriately, which can reduce the power consumption and increase the range.
Nonuniform Bose–Einstein condensate: II. Doubly coherent states
Authors: Tomchenko Maksim 
Published: November 2024

Abstract
We find stationary excited states of a one-dimensional system of N spinless point bosons with repulsive interaction and zero boundary conditions by numerically solving the time-independent Gross–Pitaevskii equation. The solutions are compared with the exact ones found in the Bethe-ansatz approach. We show that the jth stationary excited state of a nonuniform condensate of atoms corresponds to a Bethe-ansatz solution with the quantum numbers

n

1

=

n

2

=
…
=

n

N

=
j
+
1

. On the other hand, such values of

n

1

,
…
,

n

N

correspond to a condensate of N elementary excitations (the Bogoliubov quasiparticles) with the quasimomentum

ℏ
π
j

/

L

, where L is the system size. Thus, each stationary excited state of the condensate is ‘doubly coherent’, since it corresponds simultaneously to a condensate of N atoms and a condensate of N elementary excitations. We find the energy E and the particle density profile

ρ
(
x
)

for such states. The possibility of experimental production of these states is also discussed.
Effect of heat treatment over the mechanical properties and the resistance to corrosion of the ternary Cu-Al-Ag alloy
Authors: Flores-Sanchez Daniel , Suárez-Rosales Miguel Ángel , Gutiérrez-Arzaluz Mirella , Palomar-Pardavé Manuel , Romero-Romo Mario , Landa-Castro Midori 
Published: November 2024

Abstract
In the present work, the manufacture of a Cu-9Al-3Ag alloy was carried out easily through a green molding process. After dimensioning and slitting, the alloy samples were subjected to quenching, normalizing, and annealing heat treatments, to exert phase transformations that would, in return, aid into clarifying the influence of the phases present on the mechanical properties, such as hardness, as well as the behavior when exposed to a commonly known mildly corrosive media such as NaCl. The results obtained reveal an increase in hardness (assessed through either HRB) and (microhardness HV) in the quenched and annealed sample, as well as better corrosion resistance. The characterization was carried out through optical microscopy, Scanning Electron Microscopy (SEM), Energy Dispersive Spectroscopy (EDS), potentiodynamic polarization tests and electrochemical impedance spectroscopy.
The Secularization of Knowledge
Authors: Gordon Peter E 
Published: November 2024

Abstract
The fact-value distinction is widely taken as uncontroversial; the saying that “facts are objective, values are subjective” remains a commonplace of folk epistemology. This paper aims to show that Max Weber was not in any straightforward sense a proponent of this distinction. A careful analysis of his methodological statements should prompt us to revise our understanding as to where he is situated in this philosophical controversy. The paper argues that Weber subscribed to a “quasi-transcendental” model of social-scientific knowledge according to which values serve as epistemic preconditions to facts. The paper further argues that Weber saw this model of knowledge as the outcome of a long process of secularization that culminates in a posture of social-scientific irony.
Weber’s Countergenealogy of Democracy
Authors: Turner Stephen 
Published: November 2024

Abstract
Weber’s comments on democracy are puzzling, and even more puzzling when they are reinterpreted in terms of what came to be called “democratic theory” in academic circles. The list of puzzling statements is long, involving such notions as nonlegitimate domination. The distinction he made between democracy and authority—which he took to be mutually incompatible concepts in their pure forms—excludes the possibility of legitimate democratic authority. The reasoning is comparable to similar claims by Hans Kelsen, for similar theoretical reasons rooted in the philosophy of law. The result is that what we regard as democracies Weber regarded as mixed or transitional forms. What he focuses on instead is the modern state as found only in the West, and its unique features, especially the form of parliamentary representation of the play of interests, but even more important, the concept of offices, whether in the state or in organized political parties.
Pediatric neuropsychological assessment in Southeast Asia: Current status and future directions with Vietnam as a scoping review case example
Authors: Nguyen-Martinez Ashley L , Pham Nhi , Ba Caroline , Veeramuthu Vigneswaran , Quang Halle 
Published: November 2024

Abstract

Objective
There is a concerning lack of systematic understanding regarding the availability and validity of neuropsychological assessment tools for children in Southeast Asia. This issue is further complicated by the unclear landscape for test development, adaptations, and translations in these countries. The purpose of this paper is twofold. First, we offer insights into the broader practice of pediatric neuropsychology within Southeast Asia communities based on their current medical infrastructural standings. Then, we provide a specific case study by examining the current status of pediatric neuropsychology for Vietnamese children.

Method
A brief overview of the status of pediatric neuropsychology in Southeast Asia groups is provided, followed by a scoping review examining performance-based and objective rating inventories for the Vietnamese pediatric population.

Results
42 studies were included in the Vietnamese review spanning several cognitive and socioemotional domains. Adaptation and translation protocols were significantly variable. Figures and tables summarizing the identified questionnaires and test measures are included.

Conclusions
Vietnam, with its moderately developed medical infrastructure and shared cultural, economic, and sociopolitical traits with other Southeast Asian countries, provides a compelling case study for the growth, challenges, and gaps in neuropsychology. While the field continues to develop in this country, ongoing opportunities and the need for guidelines on test development and adaptation are critically needed to advance the field further. Implications for more and less developed Southeast Asia countries are provided based on our scoping review.
The roles of interleukin (IL)-17A and IL-17F in hidradenitis suppurativa pathogenesis: evidence from human in vitro preclinical experiments and clinical samples
Authors: Rastrick Joseph , Edwards Hannah , Ferecskó Alex S , Le Friec Gaëlle , Manghera Avneet , Page Matthew , Shaw Stevan 
Published: November 2024

Abstract

Background
Hidradenitis suppurativa (HS) is a chronic relapsing inflammatory skin disease associated with significant comorbidities and poor quality of life. Despite uncertainty about pathways driving inflammation in HS lesions, the cytokines interleukin (IL)-17A and IL-17F have been shown to be upregulated in patients with HS. Previous studies have demonstrated that the monoclonal IgG1 antibody bimekizumab selectively inhibits IL-17F in addition to IL-17A.

Objectives
To further investigate the roles of IL-17A and IL-17F in HS pathogenesis.

Methods
RNA sequencing (RNAseq) was conducted on skin biopsies taken at baseline and after treatment at week 12 of a phase II proof-of-concept study of bimekizumab in patients with moderate-to-severe HS. Differentially expressed genes were identified between baseline lesional and nonlesional samples and between lesional samples before and after bimekizumab treatment, to describe molecular disease mechanisms and treatment effect. Human hair follicular keratinocytes (HHFK) were cultured and treated with a supernatant of stimulated T helper (Th)17 cells in combination with anti-IL-17A, anti-IL-17F, anti-IL-17A and anti-IL-17F, or IgG control antibodies. Total mRNA was analysed by RNAseq. Cellular supernatants from the stimulated HHFKs were used as a source of Th17-induced chemoattractants in neutrophil chemotaxis assays.

Results
RNAseq revealed that the most prominently upregulated genes in HS lesions included those associated with neutrophil biology. Bimekizumab treatment resulted in reduced expression of these genes. The extent of reduction in gene expression was dependent on achieving HiSCR50 (≥ 50% reduction from baseline in the total abscess and inflammatory nodule count, with no increase from baseline in abscess or draining tunnel count). In vitro dual inhibition of IL-17A and IL-17F had greater attenuation of Th17-induced HS-associated genes and neutrophil migration in HHFKs vs. IL-17A or IL-17F inhibition alone. In situ hybridization found that IL-17A- and IL-17F-producing cells in HS lesions can lack the IL-23 receptor and IL-1β could induce IL-23-independent IL-17F expression in vitro. Furthermore, mucosal-associated invariant cells in HS tunnels expressed IL-17F and IL-1 receptor type 1. IL-1β-, IL-17A- and IL-17F-expressing cells were found to be co-localized in HS lesions.

Conclusions
These data support the hypothesis that IL-17A and IL-17F play central roles in HS, a neutrophilic dermatosis. The presence of IL-1β may partly explain the high expression of IL-17F in lesional HS tissue.
Variation in surgery postponement rates in the NHS in England
Authors: McCone Emma , Snowden Chris , Swart Michael , Briggs Tim W R , Gray William K 
Published: November 2024

Abstract

Introduction
Postponement of surgery at preoperative assessment in the days or weeks before the patient is admitted for surgery, as distinct from cancellation on the planned day of surgery, can be devastating for patients and an inefficient use of finite resources. However, postponements are often poorly recorded. The primary aim of this pilot study was to investigate elective surgical postponement rates during or after preoperative assessment across England, and the reasons for postponement for patients on an elective surgical pathway.

Methods
A retrospective analysis of clinical audit data from 16 National Health Service (NHS) trusts in England was undertaken. Data were collected during a two-week period in March 2024 on all postponements within a service. The primary outcome of interest was the postponement rate.

Results
Some 8000 case notes were reviewed. There were 583 (7.3%) postponements. Postponement rates across trusts varied from 31.9% to 1.0%. Significantly shorter time from referral to preoperative assessment was observed for day-case patients, urgent patients, patients without early screening and patients without a ‘to come in’ date in place. Of the 342 routine patients, 293 (85.7%) had postponements for medical rather than pathways or process reasons. Half of all routine patients waited over 94 days and a quarter of patients waited 198 days from being added to a patient tracking list to preoperative assessment.

Conclusions
Minimizing postponements and improving preoperative assessment efficiency should be part of wider initiatives to streamline perioperative pathways.
Regulation of blood pressure by METTL3 via RUNX1b–eNOS pathway in endothelial cells in mice
Authors: Zhang Yanhong , Yang Xiaoxiao , Lan Mei , Yuan Ze , Li Shuai , Liu Yangping , Han Cha , Ai Ding , Yang Yang , Zhu Yi , Li Bochuan 
Published: November 2024

Abstract

Aims
Endothelial cells regulate vascular tone to control the blood pressure (BP) by producing both relaxing and contracting factors. Previously, we identified methyltransferase-like 3 (METTL3), a primary N6-methyladenosine (m6A) methyltransferase, as a key player in alleviating endothelial atherogenic progression. However, its involvement in BP regulation remains unclear.

Methods and results
To evaluate the role of METTL3 in vivo, mice with EC specific METTL3 deficiency (EC-Mettl3KO) with or without Ang II infusion were used to create a hypertensive model. Functional and MeRIP sequencing analysis was performed to explore the mechanism of METTL3-mediated hypertension. We observed a reduction in endothelial METTL3 activity by Ang II in vitro and in vivo. Endothelial METTL3-deficient mice exhibited higher BP than controls, with no gender disparity observed. The subsequent study was primarily conducted in male mice. Through m6A sequencing and functional analysis, we identified m6A modification of various RUNX1 monomers resulted in endothelial dysfunction. Mutations in the 3′UTR region of RUNX1b abolished its luciferase reporter activity and enhanced eNOS promoter luciferase reporter activity with or without METTL3 overexpression. Overexpression of METTL3 by adeno-associated virus reduced Ang II-induced BP elevation.

Conclusion
This study reveals that METTL3 alleviates hypertension through m6A-dependent stabilization of RUNX1b mRNA, leading to up-regulation of eNOS, thus underscoring the pivotal role of RNA transcriptomics in the regulation of hypertension.
Scenarios, not shortage forecasts, are key to better workforce policy
Authors: Buntin Melinda J B , Chen Mingxin , Auerbach David I 
Published: November 2024

Abstract
Current and projected shortages in the US health workforce have prompted policymakers to propose reforms to Medicare Graduate Medical Education (GME) and nursing programs. However, researchers have historically faced challenges in accurately predicting workforce trends; physician and nurse supply and demand all grew faster than expected over the past 2 decades. These discrepancies highlight the need for scenario-based workforce planning and projection models that estimate how a policy intervention would affect the workforce outcome of interest. In addition, policy options modeled should address not only increasing provider-to-population ratios but also improving health outcomes through innovative payment and care models.
Loss of paired immunoglobin-like type 2 receptor B gene associated with age-related macular degeneration impairs photoreceptor function in mouse retina
Authors: Dey Partha Narayan , Singh Nivedita , Zelinger Lina , Batz Zachary , Nellissery Jacob , White Carreiro Noor D , Qian Haohua , Li Tiansen , Fariss Robert N , Dong Lijin , Swaroop Anand 
Published: November 2024

Abstract
Genome-wide association studies have uncovered mostly non-coding variants at over 60 genetic loci linked to susceptibility for age-related macular degeneration (AMD). To ascertain the causal gene at the PILRB/PILRA locus, we used a CRISPR strategy to produce germline deletions in the mouse paired immunoglobin-like type 2 receptor (Pilr) genes that encode highly related activating (PILRB) and inhibitory (PILRA) receptors. We show that a combined loss of Pilrb1 and Pilrb2, but not Pilra, leads to an early but relatively stationary defect as the electroretinography (ERG) amplitudes of Pilrb1/2−/− mice exhibit a marked reduction as early as postnatal day 15 and do not show additional significant decrease at 3 and 12-months. No alterations are evident in Müller glia, microglia, bipolar, amacrine and horizontal cells based on immunohistochemistry using cell-type specific markers. PILRB immunostaining is specifically detected at the proximal part of photoreceptor outer segment. Reduced expression of select calcium-regulated phototransduction and synapse-associated proteins, including GCAP1 and 2, PDE6b, AIPL1, PSD95, and CTBP1 indicates dysregulation of calcium homeostasis as a possible mechanism of retinal phenotype in Pilrb1/2−/− mice. Our studies suggest a novel function of PILRB in retinal photoreceptors and an association of PILRB, but not PILRA, with AMD pathogenesis.
Urea assimilation and oxidation support activity of phylogenetically diverse microbial communities of the dark ocean
Authors: Arandia-Gorostidi Nestor , Jaffe Alexander L , Parada Alma E , Kapili Bennett J , Casciotti Karen L , Salcedo Rebecca S R , Baumas Chloé M J , Dekas Anne E 
Published: November 2024

Abstract
Urea is hypothesized to be an important source of nitrogen and chemical energy to microorganisms in the deep sea; however, direct evidence for urea use below the epipelagic ocean is lacking. Here, we explore urea utilization from 50 to 4000 meters depth in the northeastern Pacific Ocean using metagenomics, nitrification rates, and single-cell stable-isotope-uptake measurements with nanoscale secondary ion mass spectrometry. We find that on average 25% of deep-sea cells assimilated urea-derived N (60% of detectably active cells), and that cell-specific nitrogen-incorporation rates from urea were higher than that from ammonium. Both urea concentrations and assimilation rates relative to ammonium generally increased below the euphotic zone. We detected ammonia- and urea-based nitrification at all depths at one of two sites analyzed, demonstrating their potential to support chemoautotrophy in the mesopelagic and bathypelagic regions. Using newly generated metagenomes we find that the ureC gene, encoding the catalytic subunit of urease, is found within 39% of deep-sea cells in this region, including the Nitrososphaeria (syn., Thaumarchaeota; likely for nitrification) as well as members of thirteen other phyla such as Proteobacteria, Verrucomicrobia, Plantomycetota, Nitrospinota, and Chloroflexota (likely for assimilation). Analysis of public metagenomes estimated ureC within 10–46% of deep-sea cells around the world, with higher prevalence below the photic zone, suggesting urea is widely available to the deep-sea microbiome globally. Our results demonstrate that urea is a nitrogen source to abundant and diverse microorganisms in the dark ocean, as well as a significant contributor to deep-sea nitrification and therefore fuel for chemoautotrophy.