bluuebunny/crossref_metadata_2025_split huggingface dataset:
Unexpected positron emission tomography/computed tomography uptake in benign dermal naevus
Authors: Robinson Mitchell , Curchin Claudia , Soyer H. Peter 
Published: July 2018

AbstractPositron emission tomography/computed tomography (PET/CT) imaging modalities are commonly utilised for investigation of known or suspected neoplastic disease. A variety of 18‐F‐fluorodeoxyglucose (FDG) positive cutaneous lesions have been described in the literature, including both malignant lesions and benign inflammatory conditions. We report a case of PET/CT‐positive dermal naevus.
Role of vitamin C in wound healing after dental implant surgery in patients treated with bone grafts and patients with chronic periodontitis
Authors: Li Xiao , Tang Li , Lin Yong Feng , Xie Gui Fang 
Published: July 2018

AbstractBackgroundPostoperative wound healing is an important part of the success of the dental implant surgery. However, in case of complex surgery or unfavorable factors, wound healing is often unsatisfactory.ObjectiveThe aim of this study was to explore the effects of vitamin C supplementation in wound healing, following the placement of dental implants with or without bone grafts and patients with chronic periodontitis.MethodsThis randomized controlled clinical trial included 128 patients requiring dental implants to replace missing teeth. Patients were divided into four groups, group A received dental implants supported by guided bone regeneration (GBR) technique, group B received dental implants with Bio‐Oss Collagen, group C received dental implants in patients with chronic periodontitis, and group D received dental implants without any bone grafting or periodontal disease. Each group was divided into an experimental subgroup, who received vitamin C, and a control subgroup. Follow‐up appointments were performed at day 3, day 7, and day 14 postsurgery, during which soft tissue healing and pain response scores were evaluated using the Landry index and visual analogue scale, respectively.ResultsThe experimental subgroups had significantly higher healing indices than the controls (P < .05) at day 7 postsurgery for group B and day 14 postsurgery for groups A, B, and C. Group D displayed no difference between the experimental and control groups at any time point. In reference to vitamin C for pain relief, there were no statistically significant differences between the study groups.ConclusionUsing vitamin C supplementation improves postoperative healing following dental implant surgery in patients with chronic periodontitis and patients treated with GBR or Bio‐Oss Collagen grafts. However, vitamin C supplementation does not decrease the postoperative pain associated with dental implant surgery.
Effect of substrate stiffness on proliferation and differentiation of periodontal ligament stem cells
Authors: Liu Nanxin , Zhou Mi , Zhang Qi , Yong Li , Zhang Tao , Tian Taoran , Ma Quanquan , Lin Shiyu , Zhu Bofeng , Cai Xiaoxiao 
Published: July 2018

AbstractObjectivesThe aim of this study was to understand the effect of substrate stiffness (a mechanical factor of the extracellular matrix) on periodontal ligament stem cells (PDLSCs) and its underlying mechanism.Materials and methodsElastic substrates were fabricated by mixing 2 components, a base and curing agent in proportions of 10:1, 20:1, 30:1 or 40:1.PDLSCmorphology was observed using scanning electron microscopy (SEM). Cell proliferation and differentiation were assessed afterPDLSCs was cultured on various elastic substrates. Data were analysed using one‐wayANOVA.ResultsSEMrevealed variations in the morphology ofPDLSCs cultured on elastic substrates.PDLSCproliferation increased with substrate stiffness (P < .05). Osteogenic differentiation ofPDLSCs was higher on stiff substrates. Notch pathway markers were up‐regulated inPDLSCs cultured on stiff substrates.ConclusionsResults suggested that the osteogenic differentiation ofPDLSCs might be promoted by culturing them in a stiffness‐dependent manner, which regulates the Notch pathway. This might provide a new method of enhancing osteogenesis inPDLSCs.
Evidence behind the use of molecular tests in melanocytic lesions and practice patterns of these tests by dermatopathologists
Authors: Emanuel Patrick O. , Andea Aleodor A. , Vidal Claudia I. , Missall Tricia A. , Novoa Roberto A. , Bohlke Angela K. , Hughes Sarah R. , Hurley Maria Y. , Kim Jinah 
Published: July 2018

BackgroundThe gold standard for the diagnosis of melanocytic lesions is histologic examination. However, as histologic examination can have its limitations, there are many clinical scenarios in which additional testing may be appropriate in an attempt to render a definitive diagnosis.MethodsA literature review for three ancillary tests—comparative genomic hybridization (CGH)/single‐nucleotide polymorphism (SNP) array, fluorescence in situ hybridization (FISH), and gene expression profiling by quantitative reverse transcription polymerase chain reaction (qRT‐PCR)—was compiled and current use patterns were tabulated. Survey of the practice patterns of these tests by dermatopathologists was also accessed in the attendees of the American Society of Dermatopathology Annual Meeting (Chicago, 2016).ResultsHere we summarize the use of these molecular tests in melanocytic lesions. We found that 54.4% of the respondents surveyed utilize (or expect consultants to utilize) molecular testing of melanocytic lesions in their practice when appropriate.ConclusionsCGH/SNP arrays, FISH testing, and qRT‐PCR applied to melanocytic lesions have allowed for more accurate classification. Just over half of those surveyed use molecular testing for melanocytic lesion with the majority sending their cases out for completion of the molecular test.
Sarcopenia is associated with blood pressure variability in older patients with type 2 diabetes: A cross‐sectional study of the KAMOGAWA‐DM cohort study
Authors: Hashimoto Yoshitaka , Kaji Ayumi , Sakai Ryosuke , Hamaguchi Masahide , Okada Hiroshi , Ushigome Emi , Asano Mai , Yamazaki Masahiro , Fukui Michiaki 
Published: July 2018

AimTo investigate the association between sarcopenia and blood pressure parameters in older patients with type 2 diabetes.MethodsThis was a cross‐sectional study of 146 older patients with diabetes. Body composition was evaluated by bioimpedance analysis. The skeletal muscle mass index (kg/m2) was defined as appendicular muscle mass / the square of the height. Patients with both handgrip strength <26 kg for men and <18 kg for women, and skeletal muscle mass index <7.0 kg/m2 for men and <5.7 kg/m2 for women were diagnosed as sarcopenia. We measured systolic blood pressure (SBP) at every visit for 1 year and calculated the coefficient of variation of SBP.ResultsAmong 146 patients (86 men and mean age 72.6 years [SD 5.9 years], 21 patients (14.4%) were sarcopenic. The coefficient of variation of SBP in patients with sarcopenia was higher than that in patients without sarcopenia (9.1 [SD 3.2] vs 7.1 [SD 2.9]%, P = 0.007), although the average SBP of patients with sarcopenia and that of patients without sarcopenia was not different (129.5 [SD 14.0] vs 130.5 [SD 12.9] mmHg, P = 0.558). Multiple regression analysis showed that sarcopenia was associated with the coefficient of variation of SBP (β = 0.20, P = 0.024), even after adjusting for covariates, whereas sarcopenia was not associated with the average SBP (β = 0.05, P = 0.558).ConclusionsWe showed that sarcopenia was associated with blood pressure variability, whereas not with the average SBP. It is necessary for clinicians to pay careful attention to blood pressure variability when examining patients with sarcopenia. Geriatr Gerontol Int 2018; 18: 1345–1349.
A survey on obstacles and difficulties of practical implementation of horizontal collaboration in logistics
Authors: Basso Franco , D'Amours Sophie , Rönnqvist Mikael , Weintraub Andrés 
Published: July 2018

AbstractDuring recent years, horizontal collaboration in logistics has gained attention because of achieved potential benefits such as cost reduction, an increase in fulfillment rates, and a decrease in CO2 emissions owing to reductions in traveled distances. Successful real‐world cases, however, are rare since horizontal cooperation in logistics is not usually sustainable. This paper pays attention to this paradox of the lack of cases and discusses 16 identified practical issues that could explain this phenomenon. We propose a taxonomy composed of four categories categorizing the practical issues according to a value chain approach: design, planning and operations, market/business, and behaviors. Furthermore, we propose and discuss some measures to mitigate these problems.
The dual role of N6‐methyladenosine modification of RNAs is involved in human cancers
Authors: He Liujia , Li Jiangfeng , Wang Xiao , Ying Yufan , Xie Haiyun , Yan Huaqing , Zheng Xiangyi , Xie Liping 
Published: July 2018

AbstractAs the most abundant and reversible RNA modification in eukaryotic cells, m6A triggers a new layer of epi‐transcription. M6A modification occurs through a methylation process modified by “writers” complexes, reversed by “erasers”, and exerts its role depending on various “readers”. Emerging evidence shows that there is a strong association between m6A and human diseases, especially cancers. Herein, we review bi‐aspects of m6A in regulating cancers mediated by the m6A‐associated proteins, which exert vital and specific roles in the development of various cancers. Generally, the m6A modification performs promotion or inhibition functions (dual role) in tumorigenesis and progression of various cancers, which suggests a new concept in cancer regulations. In addition, m6A‐targeted therapies including competitive antagonists of m6A‐associated proteins may provide a new tumour intervention in the future.
Aeromonas shuberti as a cause of multi‐organ necrosis in internal organs of Nile tilapia, Oreochromis niloticus
Authors: Liu C , Chang O Q , Zhang D F , Li K B , Wang F , Lin M H , Shi C B , Jiang L , Wang Q , Bergmann S M 
Published: July 2018

AbstractA disease with white spots in internal organs of Nile tilapia occurred in Zhanjiang, southern China. Multiple, white nodules, 0.8–2.2 mm in diameter, were scattered throughout the liver, spleen and kidney of diseased fish. Signs of nodules reproduced after artificial infection with the isolated strain. Isolated bacteria were Gram‐negative, facultative anaerobic, motile, short rod‐shaped, with a length of 1.2–2.2 μm. Morphological and biochemical tests, as well as phylogenetic analysis, all strongly indicated that the isolate from tilapia is identical to Aeromonas schubertii (A. schubertii) which temporary named LF1708 strain. Antibiotic sensitivity assays showed the LF1708 is sensitive to 24 of 27 tested antibiotics. Pathogenicity test revealed that the isolate at the dose of 3.75 × 106 CFU/g killed 100% of experimental tilapia within 2 days and the dose of 1 × 107 CFU/g killed 100% of experimental zebrafish within 1 day. Histopathology of diseased tilapia infected with A. schubertii showed numerous necrotic lesions widely distributed in spleen, liver and kidney, and infiltration with a large number of bacteria. To our knowledge, this was the first report that associated A. schubertii with mortality in tilapia.
Seasonal recovery of Edwardsiella piscicida from wild European eels and natural waters: Isolation methods, virulence and reservoirs
Authors: Esteve Consuelo , Alcaide Elena 
Published: July 2018

AbstractA total of 127 wild eels caught in the L′Albufera Lake (Spain) and 24 samples of lagoon freshwater were analysed for 1‐year period. Edwardsiella strains were isolated from liver/kidney on TSA‐1 plates in 31.9% of total diseased specimens, and the edwardsiellosis prevalence in the fishery was of 11.8%. The use of double‐strength Salmonella‐Shigella (DSSS) broth and SS agar yielded Edwardsiella isolation from intestine in 100% of those edwardsiellosis‐diseased eels, but also in 40.4% of other sick fish with vibriosis or aeromonosis and in 28.8% of healthy eels, as well as from freshwater in 8.3% of samples. Pure cultures were isolated on SS agar from the former, but motile Aeromonas, Plesiomonas shigelloides and Hafnia alvei were recovered along with Edwardsiella in the other samples. Edwardsiella isolates identification at species level revealed that E. piscicida was distributed between wild eels and freshwater but E. tarda only did in freshwater. All E. piscicida strains were virulent for eels (LD < 1.0 × 106 CFU/fish) but that of E. tarda was not. This is the first report of E. piscicida in wild eel intestines and natural freshwater, highlighting its role as potential reservoirs for the bacterium. A seasonal recovery was found for E. piscicida at water temperature above 20°C.
Growth and Public Debt: What Are the Relevant Trade‐Offs?
Authors: CHERON ARNAUD , NISHIMURA KAZUO , NOURRY CARINE , SEEGMULLER THOMAS , VENDITTI ALAIN 
Published: July 2018

AbstractThe interplay between growth and public debt is addressed considering a Barro‐type (1990) endogenous growth model where public spendings are financed through taxes on income and public debt. The government has a target level of public debt relative to GDP, and the long‐run debt‐to‐GDP ratio is used as a policy parameter. We show that when debt is a large enough proportion of GDP, two distinct balanced‐growth paths (BGPs) may coexist, one being indeterminate. We exhibit two types of important trade‐offs associated with self‐fulfilling expectations. First, we show that the lowest BGP is always decreasing with respect to the debt‐to‐GDP ratio while the highest one is increasing. Second, we show that the highest BGP, which provides the highest welfare, is always locally indeterminate while the lowest is always locally determinate. Therefore, local and global indeterminacy may arise and self‐fulfilling expectations appear as a crucial ingredient to understand the impact of debt on growth, welfare, and macroeconomic fluctuations. Finally, a simple calibration exercise allows to provide an understanding of the recent experiences of many OECD countries.
Adding unregulated nursing support workers to ward staffing: Exploration of a natural experiment
Authors: Duffield Christine , Roche Michael , Twigg Di , Williams Anne , Rowbotham Samantha , Clarke Sean 
Published: July 2018

AbstractAims and objectivesTo explore the impact of an initiative to add unregulated nursing support workers to wards in acute care hospitals.BackgroundAdding nursing support workers to existing nurse staffing may be one solution to reduce nursing workloads and improve outcomes. However, the effects of this addition on nurse, patient and system outcomes are not well documented. In one state of Australia, a trial deployment of nursing support workers to wards across the public health system provided opportunity for the exploration of their impact in a natural, real‐world, environment.DesignCross‐sectional study.MethodsA sample of five wards where nursing support workers had been added matched to a group of five wards where there were no nursing support workers. Data were collected via patient survey (n = 141) and nurse survey (n = 154). Analysis was comparative with regression models constructed for the different ward types.ResultsNursing leadership, staffing and resources, and nurse experience were linked to outcomes on both ward types. Instability was a significant predictor of reduced quality of care and increased turnover intention on wards where support workers were added.ConclusionAdding nursing support workers to ward staffing did not lead to improvements in patient care. Findings suggest that staffing a nursing ward is a complex activity and that a simple approach to staffing is unlikely to be successful. Future research should explore the process of implementation and the conditions under which this strategy is likely to be successful.Relevance to clinical practiceWard‐level factors are key in making appropriate staffing and skill mix choices to limit instability and to consequently avoid negative patient, staff and system outcomes. Consideration of the ward context, alongside effective delegation processes and integration into the care team are imperative when adding nursing support workers.
A 2‐year longitudinal study of the relationship between masticatory function and progression to frailty or pre‐frailty among community‐dwelling Japanese aged 65 and older
Authors: Horibe Yasuhiro , Ueda Takayuki , Watanabe Yutaka , Motokawa Keiko , Edahiro Ayako , Hirano Hirohiko , Shirobe Maki , Ogami Koichiro , Kawai Hisashi , Obuchi Shuichi , Kim Hunkyung , Sakurai Kaoru 
Published: July 2018

AbstractBackgroundAn association has recently been reported between frailty and reduced masticatory function; however, the causal relationship remains unclear.ObjectiveThe aim of this study was to clarify the relationship between masticatory function and frailty progression.MethodsAmong 6699 individuals aged 65 and older (mean age 72.8 ± 5.2 years) who were invited to participate in comprehensive medical check‐ups, 418 who underwent examinations at the Tokyo Metropolitan Institute of Gerontology in both 2013 and 2015 and who met inclusion criteria were included in this study. Frailty was determined with the Kihon Checklist developed by the Japanese Ministry of Health, Labour and Welfare. The following three masticatory functions were evaluated: occlusal force, mixing ability and subjective chewing ability. The following confounding factors were investigated: age, sex, grip strength, comfortable walking speed, Mini‐Mental State Examination (MMSE) score, Self‐Rating Depression Scale (SDS) score, skeletal mass index (SMI), number of medications taken and number of remaining teeth. Statistical analysis was performed with binomial logistic regression analysis.ResultsLogistic regression analysis revealed that comfortable walking speed, SDS score, MMSE score and masticatory function were significantly related to progression to frailty or pre‐frailty. Of the three masticatory function items evaluated, mixing ability and subjective chewing ability were related to frailty progression.ConclusionOur results confirm that masticatory function was associated with the progression to pre‐frailty or frailty among community‐dwelling individuals 65 years and older over the 2‐year period of this longitudinal study. Of the masticatory function items evaluated, mixing ability and subjective chewing ability were associated with frailty progression.
Canine hyperadrenocorticism associations with signalment, selected comorbidities and mortality within North American veterinary teaching hospitals
Authors: Hoffman J. M. , Lourenço B. N. , Promislow D. E. L. , Creevy K. E. 
Published: July 2018

ObjectiveTo describe a large population of dogs with a diagnosis of hyperadrenocorticism at the time of death in North American veterinary teaching hospitals, and to identify comorbid conditions associated with hyperadrenocorticism.Materials and MethodsRetrospective cohort study of 1519 dogs with hyperadrenocorticism from a population of 70,574 dogs reported to the Veterinary Medical Database. Signalment, presence or absence of hyperadrenocorticism, aetiology of hyperadrenocorticism (if described), frequency of select comorbidities and causes of death were evaluated in dogs with and without hyperadrenocorticism.ResultsHyperadrenocorticism was more frequent in females. Neutering was associated with a minor, but significant, increase in the odds of hyperadrenocorticism. Hyperadrenocorticism was the presumed cause of death of 393 (25∙9%) of affected dogs. When aetiology was specified (527 dogs, corresponding to 34∙7% of the cases), pituitary‐dependent hyperadrenocorticism [387 (73∙4%) out of 527 dogs] was more common than functional adrenocortical tumour [136 (25∙8%) out of 527 dogs). Hyperadrenocorticism was over‐represented in certain expected (miniature poodle, dachshund) and unexpected (Irish setter, bassett hound) breeds compared with the population at large. Of the select comorbidities investigated, dogs with hyperadrenocorticism were at increased risk for concurrent diabetes mellitus, urinary tract infection, urolithiasis, hypertension, gall bladder mucocoele and thromboembolic disease compared with dogs without hyperadrenocorticism.Clinical SignificanceHyperadrenocorticism is significantly associated with certain comorbid conditions but is not a major cause of mortality in affected dogs. Documented patterns now provide targets for prospective clinical research.
Sleep latency versus shuteye latency: Prevalence, predictors and relation to insomnia symptoms in a representative sample of adults
Authors: Exelmans Liese , Gradisar Michael , Van den Bulck Jan 
Published: July 2018

AbstractShuteye latency (SEL) refers to the time spent performing activities in bed before attempting sleep. This study investigates (a) the prevalence, duration and predictors of SEL, (b) its association with insomnia symptoms (sleep onset latency [SOL], sleep quality and fatigue), and (c) the activities engaged in during SEL. A representative sample of 584 adults (18–96 years old) participated in an online survey. Respondents reported their SEL on weekday nights (Sunday to Thursday) and weekend nights (Friday and Saturday), and activities during SEL. One in five adults tried to sleep immediately at bedtime. Around 16% of respondents were awake >30 min on both weekday and weekend nights. Younger people and those with an eveningness preference reported longer SEL. Longer SEL corresponded with a progressive decline in sleep quality, increased SOL and more fatigue. Those with an SEL >30 min reported using both passive (e.g. television) and interactive (e.g. smartphone) media more frequently than respondents with an SEL < 30 min, but there was no difference between the groups for non‐screen‐related activities. Implications of SEL for measurements commonly used in sleep research are discussed. Shuteye latency may be symptomatic of how a modern lifestyle puts increasing pressure on sleep, but may also reveal a previously undocumented behaviour associated with insomnia symptoms.
Upside‐Down Response to Intervention: A Quasi‐Experimental Study
Authors: Bouton Bobette , McConnell John R. , Barquero Laura A. , Gilbert Jennifer K. , Compton Donald L. 
Published: July 2018

AbstractThis quasi‐experimental study explored a response‐to‐intervention (RTI) design in which Tiers 2 and 3 were inverted for the most at‐risk first grade students in reading intervention in seven classrooms (n = 24) across two culturally diverse schools. These students were matched using propensity scores and compared to a second group of first grade at‐risk students for reading difficulties who received a traditional RTI intervention program (n = 24) from 12 classrooms across nine culturally diverse schools in the same southeastern city. Interventions were identical with the exception of the RTI tier inversion. The intervention largely emphasized word‐level reading skills, with focus on letter‐sound correspondence, sight‐word recognition, and decoding, and also included spelling and fluency. Statistically significant effects were found for the intervention on word reading measures; however, differences for decoding measures were not found to be statistically significant. Given that the decoding assessments had effect sizes of .025 (small) and .037 (medium), a larger sample may demonstrate a significant positive impact of udRTI on these measures as well. Implications for continued study with the udRTI model are discussed.
Financial models with defaultable numéraires
Authors: Fisher Travis , Pulido Sergio , Ruf Johannes 
Published: July 2018

AbstractFinancial models are studied where each asset may potentially lose value relative to any other. Conditioning on nondevaluation, each asset can serve as proper numéraire and classical valuation rules can be formulated. It is shown when and how these local valuation rules can be aggregated to obtain global arbitrage‐free valuation formulas.