bluuebunny/crossref_metadata_2025_split huggingface dataset:
C‐reactive protein is an independent prognostic marker in patients with tongue carcinoma ‐ A retrospective study
Authors: Graupp M. , Schaffer K. , Wolf A. , Vasicek S. , Weiland T. , Pondorfer P. , Holzmeister C. , Moser U. , Thurnher D. 
Published: March 2018

ObjectivesReliable prognostic markers are lacking for tongue carcinoma. C‐reactive protein (CRP) and a ratio from neutrophils/lymphocytes (NLR) are biomarkers, associated with prognosis in solid cancers. Aim of this work was to investigate the role of CRP and NLR in prognosis of patients with tongue carcinoma.DesignRetrospective cohort study.SettingWe retrospectively analysed data of patients treated for tongue carcinoma at our institution. Levels of CRP, Neutrophils and Lymphocytes were measured pretherapeutic.Participants197 patients treated for squamous cell carcinoma of the tongue between 2002 and 2015.Main outcome measuresOverall survival, disease‐free survival.ResultsElevated CRP was significantly associated with shorter overall survival in our cohort in uni‐ and multivariate analysis. NLR was not associated with prognosis.ConclusionIn the present study we could confirm the role of CRP as an independent prognostic marker in patients with tongue carcinoma. Incorporating this marker in prognostication could represent a valuable and moreover inexpensive tool for improved decisions making concerning therapy in the future.
Reliable sonographic features for nodal thyroglobulin to diagnose recurrent lymph node metastasis from papillary thyroid carcinoma
Authors: Jiang H.‐J. , Wu C.‐W. , Chiang F.‐Y. , Chiou H.‐Y.C. , Chen I.‐J. , Hsiao P.‐J. 
Published: March 2018

ObjectivesUltrasound‐guided aspiration cytology (US‐FNAC) was previously used to diagnose lymph node metastasis of papillary thyroid carcinoma (PTC). Combined US‐FNAC with nodal thyroglobulin (LN‐FNA‐Tg) significantly improved the diagnostic rate. However, diagnostic accuracy depends on proper node selection. Therefore, it is crucial to choose the nodes with reliable sonographic features to guide clinician for confirmation.Design and SettingRetrospective cohort study was carried out in one medical centre from 2011 to 2014.ParticipantsA total of 148 patients with PTC, being treated by total thyroidectomy and radioiodine, were assessed for potential nodal metastases by ultrasound.Main outcome measuresLymph nodes with cystic content, peripheral hypervascularity, calcification, hyperechoic content, the absence of hilum and Solbiati index < 2 indicated risk of malignancy. US‐FNAC and LN‐FNA‐Tg were both performed. Positive nodal metastasis was further confirmed by dissection. Risk impact of these sonographic features on LN‐FNA‐Tg to diagnose nodal metastasis was tested by logistic regression analysis based on the significance in both univariate and multivariate models.ResultsOverall, 49 lymph nodes were documented as recurrent nodal metastasis. LN‐FNA‐Tg greater than serum thyroglobulin and higher than 1 ng/mL achieved 100% of diagnostic rate for recurrent nodal metastasis. The malignant sonographic features that significantly cohered with positive LN‐FNA‐Tg were cystic and hyperechoic content and lack hilum, in sequence.ConclusionsLN‐FNA‐Tg is an excellent tool to quantitatively diagnose nodal metastasis. To achieve ideal diagnosis, the most reliable sonographic features were cystic content, hyperechoic content and the absence of hilum in lymph nodes, but not calcification or Solbiati index < 2.
High sensitivity and negative predictive value of sentinel lymph node biopsy in a retrospective early stage oral cavity cancer cohort in the Northern Netherlands
Authors: Boeve K. , Schepman K.P. , Schuuring E. , Roodenburg J.L.N. , Halmos G.B. , van Dijk B.A.C. , Boorsma R.A.C. , de Visscher J.G.A.M. , Brouwers A.H. , van der Vegt B. , Witjes M.J.H. 
Published: March 2018

ObjectivesIn cT1‐2N0, oral squamous cell carcinoma (OSCC) occult metastases are detected in 23%‐37% of cases. Sentinel lymph node biopsy (SLNB) was introduced in head and neck cancer as a minimally invasive alternative for an elective neck dissection in neck staging. Meta‐analyses of SLNB accuracy show heterogeneity in the existing studies for reference standards, imaging techniques and pathological examination. The aim of this study was to assess the sensitivity and negative predictive value (NPV) of the SLNB in detecting occult metastases in cT1‐2N0 OSCC in a well‐defined cohort.DesignRetrospective study. The SLNB procedure consisted of lymphoscintigraphy, SPECT/CT‐scanning and gamma probe detection. Routine follow‐up was the reference standard for the SLNB negative neck. Histopathological examination of sentinel lymph nodes (SLN) consisted of step serial sectioning, haematoxylin‐eosin and cytokeratin AE1/3 staining.SettingTwo comprehensive oncology centres.ParticipantsA total of 91 consecutive patients with primary cT1‐2N0 OSCC treated by primary resection and neck staging by SLNB procedure between 2008 and 2016.Main outcome measuresSensitivity and negative predictive value.ResultsIn all cases, SLNs were harvested. A total of 25 (27%) patients had tumour‐positive SLNs. The median follow‐up was 32 months (range 2‐104). Four patients were diagnosed with an isolated regional recurrence in the SLNB negative neck side resulting in an 85% sensitivity and a 94% NPV.ConclusionIn our cohort, the SLNB detected occult metastases in early OSCC with 85% sensitivity and 94% NPV. This supports that SLNB is a reliable procedure for surgical staging of the neck in case of oral cT1‐2N0 SCC.
Stable pneumorectum using an inline glove – a cost‐effective technique to facilitate transanal total mesorectal excision
Authors: Loong T. H. , Liu H. M. , Fong S. S. 
Published: March 2018

AbstractAimTransanal total mesorectal excision (taTME) is a novel approach for resection of the rectum. Use of a standard insufflator to create pneumorectum, however, results in bellowing–large heaving motions from insufflation of air that can frustrate surgery. We report the successful application of our technique, stable pneumorectum using an inline glove (SPRING), for the performance of transanal rectal excision in a series of 17 patients using a standard laparoscopic insufflator.MethodA retrospective review of 17 patients using the SPRING technique was performed between October 2015 and October 2016. Characteristics of these patients were evaluated, and technique‐related short‐term outcome was reviewed.ResultsThe SPRING technique was successfully used in patients who underwent both minimally invasive (n = 14) and open (n = 3) approaches in the abdominal stage of the surgery. In the 12 patients who had rectal cancer for whom SPRING was used to facilitate taTME there were no conversions to an alternative access for rectal resection, the median duration of the TME part of the operation was 95 min (62–147) and there was one R1 resection (8%). Billowing was not a significant problem in any of the 17 patients during the surgery.ConclusionIn this case series we have successfully shown the feasibility of the SPRING technique as a practical and cost‐effective solution to the problem of billowing during taTME.
Unified forms of the CDR method of approximate reasoning on Antanassov's intuitionistic fuzzy sets and its property analysis
Authors: Li Jun , Xu Xiaofu 
Published: March 2018

AbstractTwo basic models of fuzzy reasoning are fuzzy modus ponens and fuzzy modus tollens. Correspondingly, the key point of intuitionistic fuzzy reasoning is to solve the problems of intuitionistic fuzzy modus ponens (IFMP) and intuitionistic fuzzy modus tollens (IFMT). In many important algorithms of fuzzy reasoning, the Consequent Dilation Rule (CDR) method possesses the virtue of unconditional reductivity. This paper proposed an intuitionistic CDR (ICDR) method for IFMP and IFMT problems by extending the CDR method to the intuitionistic fuzzy reasoning. It was proved that the intuitionistic CDR methods, both for IFMP and IFMT, are unconditionally reductive in the circumstance of using residual intuitionistic implication operators. At the same time, the continuity, approximation properties and robustness of the CDR method in Łukasiewicz intuitionistic fuzzy reasoning space have been studied by using the new defined average natural distance between intuitionistic fuzzy sets.
Complementary‐based coalition formation for energy microgrids
Authors: Yasir Muhammad , Purvis Martin , Purvis Maryam , Savarimuthu Bastin Tony Roy 
Published: March 2018

AbstractIn recent years, the notion of electrical energy microgrids (MGs), in which communities share their locally generated power, has gained increasing interest. Typically, the energy generated comes from renewable resources, which means that its availability is variable, ie, sometimes there may be energy surpluses and at other times energy deficits. This energy variability can be ameliorated by trading energy with a connected electricity grid. However, since main electricity grids are subject to faults or other outages, it can be advantageous for energy MGs to form coalitions and share their energy among themselves. In this work, we present our model for the dynamic formation of such MG coalitions. In our model, MGs form coalitions on the basis of complementary weather patterns. Our agent‐based model, which is scalable and affords autonomy among the MGs participating in the coalition (agents can join and depart from coalitions at any time), features methods to reduce overall “discomfort” so that, even when all participating MGs in a coalition experience deficits, they can share energy so that their overall discomfort is reduced. We demonstrate the efficacy of our model by showing empirical studies conducted with real energy production and consumption data.
Progression and new onset of nonalcoholic fatty liver disease in living kidney donors compared to healthy controls
Authors: Katchman Helena , Zelber‐Sagi Shira , Baruch Roni , Berman Galia , Schwartz Idit F. , Schwartz Doron , Nakache Richard , Goykhman Yaacov , Katz Polina , Shibolet Oren , Shashar Moshe , Grupper Ayelet 
Published: March 2018

AbstractBackgroundThere is growing evidence linking nonalcoholic fatty liver disease (NAFLD) with reduced glomerular filtration rate (GFR). Living kidney donors do not have underlying kidney disease, but have reduced GFR as a result of nephrectomy. Whether kidney donation is associated with a higher risk for development or progression of NAFLD is currently unknown.MethodsRetrospective evaluation of metabolic parameters and sonographic evidence of NAFLD were performed in 232 living kidney donors and 162 healthy controls.ResultsA total of 25 donors and 44 controls had NAFLD at baseline. During a mean follow‐up of 6.8 years, 6 donors (24%) and 17 controls (38.6%) (P = .29) had a remission of NAFLD, related with decreased body mass index (BMI). The progression of NAFLD fibrosis score was similar in both groups. New onset of NAFLD was observed in 14 (6.8%) donors and 13 (11.01%) controls (P = .211), and was related to increased BMI and a higher baseline Fatty Liver Index score. Neither eGFR nor urine albumin excretion in the donors were related to new onset or progression of NAFLD.ConclusionsReduced kidney function secondary to kidney donation is not associated with increased incidence or progression of NAFLD.
University of Wisconsin vs normal saline solutions for preservation of blood vessels of brain dead donors: A histopathological study
Authors: Kazemi Kourosh , Nikeghbalian Zahra , Yaghmaei Shekoofeh , Nikeghbalian Saman , Shamsaeifar Alireza , Asgharnia Yasaman , Dehghankhalili Maryam , Golchini Alireza , Malekhosseini Seyed Ali 
Published: March 2018

AbstractObjectiveTo compare the cellular changes of harvested arteries which were preserved in normal saline (NS) and the standard and routinely used University of Wisconsin (UW) solution.MethodsThis experimental study was conducted on 20 brain dead patients. The femoral and iliac arteries were bilaterally removed and were placed in NS and UW solutions. The vascular change indices including endothelial detachment (ED), medial detachment (MD), and internal elastic membrane disruption (IEMD) were surveyed for each preserver in the first, 5th, 10th, and 21st day.ResultsThe mean age of the included patients was 32.28 ± 8.88 years, and there were 13 (65.0%) men and 7 (35.0%) women among the patients. The NS and UW preservation solutions were comparable regarding the indices of vascular changes at first, 5th, and 10th day of the study. Only in 21st day of the study, there was a significant difference between 2 group regarding MD changes (P = .049).ConclusionThe results of this in vitro study demonstrated that NS can be used as a worthy preserver for harvested vessels for up to 21 days, especially in resource‐limited transplantation centers.
Electrocardiographic changes before and after successful kidney transplantation and associations with cardiovascular and mortality outcomes
Authors: Paajanen Hanna , Helanterä Ilkka , Kaartinen Kati , Nikus Kjell , Eskola Markku , Groop Per‐Henrik , Koskinen Petri 
Published: March 2018

AbstractIntroductionElectrocardiographic (ECG) changes before and after kidney transplantation are not well‐defined. Our aim was to describe the evolution of ECG in patients on dialysis before and after successful kidney transplantation and to explore the association between ECG findings and major cardiovascular (CV) events and mortality after kidney transplantation.Patients and methodsElectrocardiographics were collected retrospectively 3 times: at entry to the transplantation waiting list, at transplantation, and 1 year after the transplantation from 212 kidney transplantation recipients. Altogether 19 ECG variables were analyzed.ResultsLeft ventricular hypertrophy was present in 10.2% by the Cornell voltage‐duration product criteria and 10.7% by the Sokolow‐Lyon voltage criteria before kidney transplantation. The presence of ST depression (OR 3.12, 95% CI 1.12 −8.7 and P = .03) at entry to the waiting list and Q wave at the time of transplantation (OR 3.28, 95% CI 1.06‐10.10 and P = .04) were both independently associated with major CV events after the transplantation. In addition, the presence of Q wave at entry to the waiting list was a risk factor of premature death after the transplantation (OR 2.92, 95% CI 1.06‐8.05 and P = .04).DiscussionCareful analysis of the ECG before transplantation can be used to estimate cardiovascular events and mortality risk after kidney transplantation.
Association Between Serotonin Syndrome and Second‐Generation Antipsychotics via Pharmacological Target‐Adverse Event Analysis
Authors: Racz Rebecca , Soldatos Theodoros G. , Jackson David , Burkhart Keith 
Published: March 2018

AbstractCase reports suggest an association between second‐generation antipsychotics (SGAs) and serotonin syndrome (SS). The US Food and Drug Administration (FDA) Adverse Event Reporting System (FAERS) was analyzed to generate hypotheses about how SGAs may interact with pharmacological targets associated with SS. FAERS was integrated with additional sources to link information about adverse events with drugs and targets. Using Proportional Reporting Ratios, we identified signals that were further investigated with the literature to evaluate mechanistic hypotheses formed from the integrated FAERS data. Analysis revealed common pharmacological targets perturbed in both SGA and SS cases, indicating that SGAs may induce SS. The literature also supported 5‐HT2A antagonism and 5‐HT1A agonism as common mechanisms that may explain the SGA‐SS association. Additionally, integrated FAERS data mining and case studies suggest that interactions between SGAs and other serotonergic agents may increase the risk for SS. Computational analysis can provide additional insights into the mechanisms underlying the relationship between SGAs and SS.
Assessment of Relative Bioavailability of Moroctocog Alfa and Moroctocog Alfa (AF‐CC) in Subjects With Severe Hemophilia A
Authors: Korth‐Bradley Joan , Rupon Jeremy , Plotka Anna , Charnigo Robert , Rendo Pablo 
Published: March 2018

AbstractAn open‐label, single‐dose, randomized, two‐period, crossover study comparing the pharmacokinetics of factor VIII activity in plasma (FVIII:C) after administration of an albumin‐free presentation of moroctocog alfa (test) and moroctocog alfa manufactured using the previous technique (reference) was conducted in 30 (25 evaluable) male subjects who had severe hemophilia A (FVIII:C < 1 IU/dL). Blood samples were collected for 48 h after administration of each dose. FVIII:C was assayed using a chromogenic substrate assay. The FVIII:C pharmacokinetic parameters were calculated using noncompartmental analysis. The presentations would be bioequivalent if the 90% confidence limits of the ratio of the geometric mean values of AUCinf and recovery fell within the interval of 80–125%. The bioequivalence criteria were met. A total of 10 treatment‐related adverse events were observed in a total of nine subjects. All were mild and none was determined to be related to administration of study medication.
Fatty Acid Amide Hydrolase Inhibition by JNJ‐42165279: A Multiple‐Ascending Dose and a Positron Emission Tomography Study in Healthy Volunteers
Authors: Postnov Andrey , Schmidt Mark E. , Pemberton Darrel J. , de Hoon Jan , van Hecken Anne , van den Boer Maarten , Zannikos Peter , van der Ark Peter , Palmer James A. , Rassnick Stef , Celen Sofie , Bormans Guy , van Laere Koen 
Published: March 2018

AbstractInhibition of fatty acid amide hydrolase (FAAH) potentiates endocannabinoid activity and is hypothesized to have therapeutic potential for mood and anxiety disorders and pain. The clinical profile of JNJ‐42165279, an oral selective FAAH inhibitor, was assessed by investigating the pharmacokinetics, pharmacodynamics, safety, and binding to FAAH in the brain of healthy human volunteers. Concentrations of JNJ‐42165279 (plasma, cerebrospinal fluid (CSF), urine) and fatty acid amides (FAA; plasma, CSF), and FAAH activity in leukocytes was determined in a phase I multiple ascending dose study. A positron emission tomography study with the FAAH tracer [11C]MK3168 was conducted to determine brain FAAH occupancy after single and multiple doses of JNJ‐42165279. JNJ‐42165279 administration resulted in an increase in plasma and CSF FAA. Significant blocking of brain FAAH binding of [11C]MK3168 was observed after pretreatment with JNJ‐42165279. JNJ‐42165279 produces potent central and peripheral FAAH inhibition. Saturation of brain FAAH occupancy occurred with doses ≥10 mg of JNJ‐42165279. No safety concerns were identified.
Novel Application of the Two‐Period Microtracer Approach to Determine Absolute Oral Bioavailability and Fraction Absorbed of Ertugliflozin
Authors: Raje Sangeeta , Callegari Ernesto , Sahasrabudhe Vaishali , Vaz Alfin , Shi Haihong , Fluhler Eric , Woolf Eric J. , Schildknegt Klaas , Matschke Kyle , Alvey Christine , Zhou Susan , Papadopoulos Dimitris , Fountaine Robert , Saur Didier , Terra Steven G. , Stevens Lloyd , Gaunt Daniel , Cutler David L. 
Published: March 2018

AbstractErtugliflozin, a sodium glucose cotransporter‐2 inhibitor, is approved in the United States for treatment of type 2 diabetes mellitus. A novel two‐period study design with 14C microtracer dosing in each period was used to determine absolute oral bioavailability (F) and fraction absorbed (Fa) of ertugliflozin. Eight healthy adult men received 100‐μg i.v. 14C‐ertugliflozin (400 nCi) dose 1 h after a 15‐mg oral unlabeled ertugliflozin dose (period 1), followed by 100 μg 14C‐ertugliflozin orally along with 15 mg oral unlabeled ertugliflozin (period 2). Unlabeled ertugliflozin plasma concentrations were determined using high‐performance liquid‐chromatography tandem mass spectrometry (HPLC‐MS/MS). 14C‐ertugliflozin plasma concentrations were determined using HPLC‐accelerator mass spectrometry (AMS) and 14C urine concentrations were determined using AMS. F ((area under the curve (AUC)p.o./14C‐AUCi.v.)*(14C‐Dosei.v./Dosep.o.)) and Fa ((14C_Total_Urinep.o./14C_Total_Urinei.v.)* (14C‐Dosei.v./14C‐Dosep.o.)) were estimated. Estimates of F and Fa were 105% and 111%, respectively. Oral absorption of ertugliflozin was complete under fasted conditions and F was ∼100%. Ertugliflozin was well tolerated.
Presence of koilocytosis in low‐grade smears of high‐risk HPV‐positive women is a negative predictor for cervical intraepithelial neoplasia grade 3 or more
Authors: Siebers A. G. , van der Linden H. , Vedder J. E. M. , Bekkers R. L. M. , Melchers W. L. G. , Bulten J. 
Published: March 2018

ObjectiveThe Netherlands converted to high‐risk (hr)HPV‐based screening in 2017. An increase in referral of hrHPV‐positive women with low risk for cervical intraepithelial neoplasia grade 3 or more (CIN3+) is anticipated and reduction of unjustified referrals will have priority. The relevance of koilocytosis in relation to the underlying risk of high‐grade CIN in a primary HPV screening setting is unclear. The aim was to investigate whether the risk for CIN3+ differs between hrHPV‐positive atypical squamous cells of undetermined significance (ASC‐US)/low‐grade squamous intraepithelial lesion (LSIL) with or without koilocytosis.MethodsRetrospective cohort study, using data from the Dutch national pathology database (PALGA). The population was 1201 hrHPV‐positive women with cytological diagnosis of ASC‐US/LSIL. Reporting of koilocytosis was assessed as well as detection rates of CIN1 or less, CIN2 and CIN3+ for ASC‐US/LSIL cytology stratified by presence or absence of koilocytosis. Crude and adjusted odds ratios were determined.ResultsKoilocytosis was present in 40.1% of ASC‐US and 45.9% of LSIL cases. CIN3+ is significantly less often found when koilocytosis is present (7.8% for hrHPV‐positive ASC‐US with‐ vs 15.8% without koilocytosis). For hrHPV‐positive LSIL this was 11.7% vs 20.2%. The crude and adjusted odds ratios for CIN3+ was 0.45 for hrHPV‐positive ASC‐US and 0.52 for hrHPV‐positive LSIL.ConclusionsThe presence of koilocytosis is a negative predictor of CIN3+. The risk of hrHPV‐positive ASC‐US with koilocytosis is in the same range as hrHPV‐positive/cytology negative cases and in a setting of primary hrHPV screening these cases could be followed conservatively by repeat cytology. The results should be confirmed by the first data from the Dutch HPV‐based screening programme.