bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fluorescence Imaging of Nerves During Surgery
Authors: Walsh Erika M. , Cole Denzel , Tipirneni Kiranya E. , Bland Kirby I. , Udayakumar Neha , Kasten Benjamin B. , Bevans Stephanie L. , McGrew Benjamin M. , Kain Joshua J. , Nguyen Quyen T. , Rosenthal Eben L. , Warram Jason M. 
Published: January 2019

Objective:
This review details the agents for fluorescence-guided nerve imaging in both preclinical and clinical use to identify factors important in selecting nerve-specific fluorescent agents for surgical procedures.

Background:
Iatrogenic nerve injury remains a significant cause of morbidity in patients undergoing surgical procedures. Current real-time identification of nerves during surgery involves neurophysiologic nerve stimulation, which has practical limitations. Intraoperative fluorescence-guided imaging provides a complimentary means of differentiating tissue types and pathology. Recent advances in fluorescence-guided nerve imaging have shown promise, but the ideal agent remains elusive.

Methods:
In February 2018, PubMed was searched for articles investigating peripheral nerve fluorescence. Key terms used in this search include: “intraoperative, nerve, fluorescence, peripheral nerve, visualization, near infrared, and myelin.” Limits were set to exclude articles exclusively dealing with central nervous system targets or written in languages other than English. References were cross-checked for articles not otherwise identified.

Results:
Of the nonspecific agents, tracers that rely on axonal transport showed the greatest tissue specificity; however, neurovascular dyes already enjoy wide clinical use. Fluorophores specific to nerve moieties result in excellent nerve to background ratios. Although noteworthy findings on tissue specificity, toxicity, and route of administration specific to each fluorescent agent were reported, significant data objectively quantifying nerve-specific fluorescence and toxicity are lacking.

Conclusions:
Fluorescence-based nerve enhancement has advanced rapidly over the past 10 years with potential for continued utilization and progression in translational research. An ideal agent would be easily administered perioperatively, would not cross the blood-brain barrier, and would fluoresce in the near-infrared spectrum. Agents administered systemically that target nerve-specific moieties have shown the greatest promise. Based on the heterogeneity of published studies and methods for reporting outcomes, it appears that the development of an optimal nerve imaging agent remains challenging.
Histopathologic Predictors of Survival and Recurrence in Resected Ampullary Adenocarcinoma
Authors: Moekotte Alma L. , Lof Sanne , Van Roessel Stijn , Fontana Martina , Dreyer Stephan , Shablak Alaaeldin , Casciani Fabio , Mavroeidis Vasileios K. , Robinson Stuart , Khalil Khalid , Gradinariu George , Mowbray Nicholas , Al-Sarireh Bilal , Fusai Giuseppe Kito , Roberts Keith , White Steve , Soonawalla Zahir , Jamieson Nigel B. , Salvia Roberto , Besselink Marc G. , Abu Hilal Mohammed 
Published: January 2019

Objective:
The aim of the study was to define histopathologic characteristics that independently predict overall survival (OS) and disease-free survival (DFS), in patients who underwent resection of an ampullary adenocarcinoma with curative intent.

Summary Background Data:
A broad range of survival rates have been described for adenocarcinoma of the ampulla of Vater, presumably due to morphological heterogeneity which is a result of the different epitheliums ampullary adenocarcinoma can arise from (intestinal or pancreaticobiliary). Large series with homogenous patient selection are scarce.

Methods:
A retrospective multicenter cohort analysis of patients who underwent pancreatoduodenectomy for ampullary adenocarcinoma in 9 European tertiary referral centers between February 2006 and December 2017 was performed. Collected data included demographics, histopathologic details, survival, and recurrence. OS and DFS analyses were performed using Kaplan–Meier curves and Cox proportional hazard models.

Results:
Overall, 887 patients were included, with a mean age of 66 ± 10 years. The median OS was 64 months with 1-, 3-, 5-, and 10-year OS rates of 89%, 63%, 52%, and 37%, respectively. Histopathologic subtype, differentiation grade, lymphovascular invasion, perineural invasion, T-stage, N-stage, resection margin, and adjuvant chemotherapy were correlated with OS and DFS. N-stage (HR = 3.30 [2.09–5.21]), perineural invasion (HR = 1.50 [1.01–2.23]), and adjuvant chemotherapy (HR = 0.69 [0.48–0.97]) were independent predictors of OS in multivariable analysis, whereas DFS was only adversely predicted by N-stage (HR = 2.65 [1.65–4.27]).

Conclusions:
Independent predictors of OS in resected ampullary cancer were N-stage, perineural invasion, and adjuvant chemotherapy. N-stage was the only predictor of DFS. These findings improve predicting survival and recurrence after resection of ampullary adenocarcinoma.
Blepharospasm as a Manifestation of Peak of Dose Dyskinesia in Parkinson Disease
Authors: Ramírez-Gómez Carolina C. , Zúñiga-Ramírez Carlos , Contartese María Laura , Montilla Verónica , Gramajo Jorge , Micheli Federico 
Published: January 2019

Objectives
The aim of the study was to report 4 patients with Parkinson disease (PD) and On-period blepharospasm (BS).

Methods
We analyzed patients with PD and motor fluctuations who developed BS in several different centers in Latin America.

Results
Four patients had BS while in the ON periods.

Conclusions
Blepharospasm in the On period in patients with PD is extremely uncommon, and our series is the only one to describe such association.
Chromatin interactome mapping at 139 independent breast cancer risk signals
Authors: Beesley Jonathan , Sivakumaran Haran , Marjaneh Mahdi Moradi , Lima Luize G. , Hillman Kristine M. , Kaufmann Susanne , Tuano Natasha , Hussein Nehal , Ham Sunyoung , Mukhopadhyay Pamela , Kazakoff Stephen , Lee Jason S. , Michailidou Kyriaki , Barnes Daniel R. , Antonio Antonis C. , Fachal Laura , Dunning Alison M. , Easton Douglas F. , Waddell Nicola , Rosenbluh Joseph , Möller Andreas , Chenevix-Trench Georgia , French Juliet D. , Edwards Stacey L. 
Published: January 2019

ABSTRACTGenome-wide association studies have identified 196 high confidence independent signals associated with breast cancer susceptibility. Variants within these signals frequently fall in distal regulatory DNA elements that control gene expression. We designed a Capture Hi-C array to enrich for chromatin interactions between the credible causal variants and target genes in six human mammary epithelial and breast cancer cell lines. We show that interacting regions are enriched for open chromatin, histone marks for active enhancers and transcription factors relevant to breast biology. We exploit this comprehensive resource to identify candidate target genes at 139 independent breast cancer risk signals, and explore the functional mechanism underlying altered risk at the 12q24 risk region. Our results demonstrate the power of combining genetics, computational genomics and molecular studies to rationalize the identification of key variants and candidate target genes at breast cancer GWAS signals.
Jet engine degradation prognostic using artificial neural networks
Authors: De Giorgi Maria Grazia , Ficarella Antonio , De Carlo Laura 
Published: January 2019

Purpose
The purpose of this paper is to propose and develop artificially intelligent methodologies to discover degradation trends through the detection of engine’s status. The objective is to predict these trends by studying their effects on the engine measurable parameters.

Design/methodology/approach
The method is based on the implementation of an artificial neural network (ANN) trained with well-known cases referred to real conditions, able to recognize degradation because of two main gas turbine engine deterioration effects: erosion and fouling. Three different scenarios are considered: compressor fouling, turbine erosion and presence of both degraded conditions. The work consists of three parts: the first one contains the mathematical model of real jet engine in healthy and degraded conditions, the second step is the optimization of ANN for engine performance prediction and the last part deals with the application of ANN for prediction of engine fault.

Findings
This study shows that the proposed diagnostic approach has good potential to provide valuable estimation of engine status.

Practical implications
Knowledge of the true state of the engine is important to assess its performance capability to meet the operational and maintenance requirements and costs.

Originality/value
The main advantage is that the engine performance data for model validation were obtained from real flight conditions of the engine VIPER 632-43.
Patterns of participation in the Grow parenting program
Authors: Czymoniewicz-Klippel Melina , Chesnut Ryan , DiNallo Jennifer , Perkins Daniel 
Published: January 2019

Purpose
Employing brief, low-intensity, face-to-face parenting programs can result in improvements in parenting and child behavior; however, their usefulness is often limited by low participation rates. Online technologies are increasingly presented as a panacea for promoting program reach in a cost-effective way. The extant literature, however, provides limited guidance on issues around the implementation of online parenting programs. Grow is a universal, health-promoting parenting program that targets families with 5–10 year olds and was developed for face-to-face delivery and then adapted for a web-based format. The purpose of this paper is to present implementation results from feasibility proof of concept studies of Grow Face-to-Face and Grow Online and explores issues regarding mode of delivery and parent participation.

Design/methodology/approach
Data were gathered from participants using attendance records, end-of-module/session surveys and semi-structured, in-depth interviews, and were examined using descriptive statistics and inductive thematic analysis.

Findings
Findings suggest that, compared to the online implementation, recruitment was more difficult for the face-to-face implementation. Conversely, retention in the online program was poorer than in the face-to-face program. Participants from both programs self-reported high levels of engagement and satisfaction. Parents who completed Grow Online expressed a desire for more interpersonal interactions, which suggests a possible need for hybrid programs that combine online technologies with traditional face-to-face modes of delivery.

Originality/value
These findings challenge the idea that the internet can fully address barriers to parenting program participation by showing that while parents may sign up more readily for an online program, they may struggle to complete all modules. This is problematic as program dosage can influence parent and child outcomes.
Corrosion characterization of Sn-Zn solder: a review
Authors: Mohd Nazeri Muhammad Firdaus , Yahaya Muhamad Zamri , Gursel Ali , Cheani Fakhrozi , Masri Mohamad Najmi , Mohamad Ahmad Azmin 
Published: January 2019

PurposeThe purpose of this paper is to review and examine three of the most common corrosion characterization techniques specifically on Sn-Zn solders. The discussion will highlight the configurations and recent developments on each of the compiled characterization techniques of potentiodynamic polarization, potentiostatic polarization and electrochemical impedance spectroscopy (EIS).Design/methodology/approachThe approach will incorporate a literature review of previous works related to the experimental setups and common parameters.FindingsThe potentiostatic polarization, potentiodynamic polarization and EIS were found to provide crucial and vital information on the corrosion properties of Sn-Zn solders. Accordingly, this solder relies heavily on the amount of Zn available because of the inability to produce the intermetallic compound in between the elements. Further, the excellent mechanical properties and low melting temperature of the Sn-Zn solder is undeniable, however, the limitations regarding corrosion resistance present opportunities in furthering research in this field to identify improvements. This is to ensure that the corrosion performance can be aligned with the outstanding mechanical properties. The review also identified and summarized the advantages, recent trends and important findings in this field.Originality/valueThe unique challenges and future research directions regarding corrosion measurement in Sn-Zn solders were shown to highlight the rarely discussed risks and problems in the reliability of lead-free soldering. Many prior reviews have been undertaken of the Sn-Zn system, but limited studies have investigated the corrosive properties. Therefore, this review focuses on the corrosive characterizations of the Sn-Zn alloy system.
Thematic framework of social media research: state of the art
Authors: Leung Xi Yu , Sun Jie , Bai Billy 
Published: January 2019

Purpose
The unprecedented growth of social media in the past decade has resulted in an increasing interest on social media research. The purpose of this study is to examine the state-of-the-art developments in social media research and to develop a thematic research framework.

Design/methodology/approach
The study reviewed 262 social media-related articles published in eight top hospitality and tourism journals between 2007 and 2017. Content analysis was used to code data from the selected articles, and correspondence analysis was then used to compare the characteristics of research conducted on different social media platforms.

Findings
A thematic framework of social media research was developed based on a thorough review and systematic examination of the articles. The thematic framework consisted of the three key players – hospitality and tourism businesses, social media platforms and consumers – along with four categories of topical areas – marketing, managerial implication, user-generated content and impact – and 19 research topics. Three platform groups were identified to share similar article characteristics and research attributes.

Originality/value
This study offers a systematic overview of social media research in hospitality and tourism and is the first one to identify triadic relationships of social media platforms in thematic research framework. The innovative findings of correspondence analysis offer insights on future social media research from a platform perspective.
The spatial ecology of sex ratios in a dioecious plant: Relations between ramet and genet sex ratios
Authors: Timerman David , Barrett Spencer C. H. 
Published: January 2019

Abstract

In clonal dioecious plants, the frequency and spatial distribution of flowering ramets contains information on the underlying genet sex ratio. These measures can also provide insight on potential ecological mechanisms causing variation and bias in sex ratios among populations.

We used a novel likelihood‐based approach and spatial clustering model to estimate the genet sex ratios from flowering ramet data collected from 32 populations of dioecious Thalictrum pubescens, a clonal species from eastern N. America that occupies moist wetland and forested environments. We investigated sex ratios of seed families, clone size, patterns of flowering and plant height to determine potential causes of sex‐ratio bias.

Flowering ramet sex ratios varied considerably among populations but were significantly male‐biased. Seed families grown to flowering also exhibited the same degree of male bias. Both models predicted close correspondence between ramet and genet sex ratios. The likelihood model revealed that sex differences in ramet production could not account for biased ramet sex ratios. The spatial clustering model indicated that ramets were significantly clustered at two spatial scales and estimated similar cluster sizes and densities for both sexes. There was no evidence for spatial segregation of the sexes. Both sexes were equally likely to flower in consecutive years and repeated bouts of flowering had no effect on ramet height.

Synthesis. Our analyses suggest that the widespread occurrence of male‐biased sex ratios in Thalictrum pubescens is unlikely to result from sexual differences in clonal growth or habitat preferences. The bias appears to become established early in the life cycle, perhaps at the seed stage as a consequence of local resource competition.
Three‐dimensional conformal radiation therapy alone for esophageal squamous cell carcinoma: 10‐year survival outcomes
Authors: Fan Xing‐Wen , Wu Jun‐Lan , Wang Hong‐Bing , Liang Fei , Jiang Guo‐Liang , Wu Kai‐Liang 
Published: January 2019

BackgroundConcurrent chemoradiation is the standard treatment for locally advanced esophageal squamous cell carcinoma (SCC). We conducted a phase II study to explore the effect of three‐dimensional conformal radiotherapy (3‐DCRT) alone for patients with locally advanced esophageal SCC. This study aimed to analyze the long‐term survival outcomes.MethodsBetween November 2004 and April 2007, 30 patients with thoracic esophageal SCC underwent late‐course sequential boost 3‐DCRT at Fudan University Shanghai Cancer Center. The planning target volume (PTV1) comprised a 1.2–1.5 cm lateral margin around the gross tumor volume and a 3.0 cm margin, superior and inferior to the gross tumor volume. PTV2 encompassed the gross tumor volume with a margin of 0.5–0.7 cm. The PTV1 dose delivered was 50 Gy, and the PTV2 dose was a boost dose of 16 Gy, resulting in a total dose of 66 Gy. No chemotherapy was administered.ResultsThe median follow‐up time was 30 months for all patients, and 132 months for patients who were alive. The median overall survival was 27 months (95% confidence interval [CI] 18.9–35.0). The 2‐, 5‐, and 10‐year overall survival rates were 56.6%, 33.3%, and 26.6%, respectively. The median progression‐free survival was 14 months (95% CI 7.7–20.2 months), and the 2‐, 5‐, and 10‐year progression‐free survival rates were 33.3%, 30.0%, and 26.6%, respectively. No severe late toxicity was observed in long‐term survivors.ConclusionLate‐course sequential boost 3‐DCRT is safe and feasible with promising long‐term outcomes for esophageal SCC.
A review of ASA physical status – historical perspectives and modern developments
Authors: Mayhew D. , Mendonca V. , Murthy B. V. S. 
Published: January 2019

SummaryThe American Society of Anesthesiologists (ASA) physical status is a tool commonly used to classify a patient's physical fitness before surgery. Since its introduction in 1941 it has undergone very few modifications to improve its reliability and to eliminate subjectivity, despite vast changes in both surgical and anaesthetic technique. We present the history of the ASA physical status and review the literature on its applicability to contemporary anaesthetic practice.
Bigger Than You Thought: China's Contribution to Scientific Publications and Its Impact on the Global Economy
Authors: Xie Qingnan , Freeman Richard B. 
Published: January 2019

AbstractChina's advance to the forefront of scientific research is one of the 21st century's most surprising developments, with implications for a world where knowledge is arguably “the one ring that rules them all.” This paper provides new estimates of China's contribution to global science that far exceed estimates based on the proportion of papers with Chinese addresses in databases of international journals. Address‐based measures ignore articles written by Chinese researchers with non‐Chinese addresses and articles in Chinese language journals not indexed in those databases. Taking account of these contributions, we attribute 36 percent of 2016 global scientific articles to China. Taking account of increased citations to Chinese‐addressed articles relative to the global average as well, we attribute 37 percent of global citations to scientific articles published in 2013 to China. With shares of articles and citations more than twice its share of global population or GDP, China has achieved a comparative advantage in knowledge that has implications for the division of labor and trade among countries and for the direction of research and of technological and economic development worldwide.
The Impact of Farmland Transfers on Agricultural Investment in China: A Perspective of Transaction Cost Economics
Authors: Gao Liangliang , Sun Dingqiang , Ma Cuiping 
Published: January 2019

AbstractThere is growing concern that farmland transfers lead to less agricultural investment, which may adversely affect agricultural productivity growth in China. Prior research has primarily focused on the differences between owned cultivated land and rented plots, but little is known about how farmland transfers between relatives, which are popular in rural China, specifically affect agricultural investment. In this paper, we present a conceptual framework of transaction cost economics to compare different contracting strategies in China's farmland rental markets. As farmland rental markets in China are immature, land transfer between relatives establishes bilateral governance, which has the advantage of addressing the opportunistic activities of both parties and can ultimately increase investment by tenants. Based on data from two waves of household surveys, we empirically examine the impact of bilateral governance on the application of organic fertilizer, an indicator for agricultural investment. Our findings show that apart from economic factors, kinship is important to the functioning of farmland rental markets in rural areas.
Socio‐economic status, social support, social network, dental status, and oral health reported outcomes in adolescents
Authors: Vettore Mario V. , Ahmad Saousan F. H. , Machuca Carolina , Fontanini Humberto 
Published: January 2019

This study explored the relationships between sex, socio‐economic status, social support, social network, dental clinical status, dental pain, oral health‐related quality of life (OHRQoL), and self‐rated oral health (SROH) in adolescents. A cross‐sectional study involving 542 adolescents, aged 12–14 yr, was conducted in Dourados, Brazil, to collect dental clinical measures (dental caries, missing teeth, and dental trauma), as well as measures of social support, social network, dental pain, OHRQoL, and SROH. Information on family income and parental education were collected from participant's parents. Structural equation modeling showed that higher income predicted better dental status and better SROH. Greater social support was linked to better dental status and better OHRQoL. Having more social networks was directly linked to better dental status. Poor dental status was linked to dental pain and poor OHRQoL. Dental pain predicted poor OHRQoL and worse SROH. Poor OHRQoL predicted worse SROH. Family income, social support, and social networks indirectly predicted dental pain via dental status. The latter was indirectly linked to OHRQoL and SROH via dental pain. Social support and social networks indirectly predicted OHRQoL and SROH via dental status and dental pain. Socio‐economic factors and social relationships should be considered when planning health promotion and dental care provision to improve an adolescent's oral health.