bluuebunny/crossref_metadata_2025_split huggingface dataset:
ASSESSING THE VALUE OF INNOVATIVE MEDICAL DEVICES AND DIAGNOSTICS: THE IMPORTANCE OF CLEAR AND RELEVANT CLAIMS OF BENEFIT
Authors: Campbell Bruce , Campbell Mark , Dobson Lee , Higgins Joanne , Dillon Bernice , Marlow Mirella , Pomfrett Chris J.D. 
Published: July 2018

Objectives:Large numbers of new medical devices and diagnostics are developed and health services need to identify which ones offer real advantages. The National Institute for Health and Care Excellence (NICE) has introduced a system for assessing technologies that are often notified by companies, based on claims made for their benefits to patients, the National Health Service, and the environment.Methods:Detailed scrutiny of claims made for the benefits of products and the corresponding evidence, seeking associations between these and the selection of products for full evaluation to produce NICE guidance.Results:Between 2009 and 2015 a NICE committee considered 169 technologies, of which it selected 74 (44 percent) for full evaluation, based on the claims of benefit and the evidence available. An average of 7.5 claims were made per technology; the total number did not influence selection but presence of studies supporting all the claims (p < .001) or any of the claims (p < .05) had a positive influence, as did claims for quicker patient recovery (p < .001). A greater number of studies to support the claims made selection more likely (p < .001), as did cohort studies (p < .05) and surveys (p < .05) but, unexpectedly, not randomized trials. The Medical Device Directive class had no influence.Conclusions:This study presents categories of claims that may be useful to those developing new products and to others engaged in health technology assessment. It illustrates the importance of relevant evidence and of having a clear vision of the place of new products in care pathways from an early stage.
Chemical composition and bioactivity of essential oil from Eucalyptus occidentalis leaves against two stored product pests
Authors: Bande-Borujeni Shokoofeh , Zandi-Sohani Nooshin , Ramezani Leila 
Published: July 2018

AbstractAttempts have been made in recent years to reduce the use of synthetic pesticides and seek alternative and innovative methods for pest control. We conducted a study on the chemical composition ofEucalyptus occidentalisessential oil and investigated the fumigant, contact and repellent effects againstTribolium castaneum(Herbst) (Col: Tenebrionidae) andRhyzopertha dominica(F.) (Col: Bostrichidae). The major components were τ-cadinol (17.20), 1,8-cineol (15.5%), α-cadinol (14%) and α-pinene (9.21%). The contact toxicity experiment showed that the oil was more toxic toR. dominica(LD50value 0.82 μL/cm) than toT. castaneum(LD50value 0.99 μL/cm) and showed the same fumigant toxicity for both insects according to the 95% confidence limit of LC50. The repellency againstT. castaneumwas more than forR. dominicaand increased from 14 to 75% forR. dominicaand 22 to 78% forT. castaneumafter 2 h. These results suggest thatE. occidentalisessential oil is a potential candidate for use as a natural repellent and insecticide for stored-product insect pests.
A review of recent discoveries of exceptionally preserved fossil fishes from the Gogo sites (Late Devonian, Western Australia)
Authors: Long John A. , Trinajstic Kate M. 
Published: July 2018

ABSTRACTSignificant new material of Late Devonian Gogo Formation fish fossils is still surfacing. Collecting in the past decade has uncovered the first Gogo shark fossils (Gogoselachusplus another new undescribed taxon), the first acanthodian (Halmacanthodes ahlbergi), the first coelacanth, as well as the first placoderm embryos. Recent studies have elucidated the nature of placoderm claspers, pelvic girdles, synarcuals and embryos, the structure of their teeth, a description of well-preserved muscles in placoderms, and how muscles attach to bones. Molecular biomarkers have also been identified in Gogo fossils. There are now five basal ray-fin fishes in the fauna, including one undescribed new taxon. The lungfish fauna from Gogo is the most diverse known for any Devonian site, with 10 genera and 12 species. The dermal skeleton and endocast of the dipteridRhinodipterus kimberleyensishave been described in detail from CT scans; and the ontogenetic stages of neurocranium formation inGriphognathus. New specimens of the tetrapodomorph fishGogonasus andrewsaehave shed further light on its endocranium, pectoral girdle and fin. Through their exceptional preservation of both hard and varied kinds of soft tissues, the Gogo fishes remain crucial for resolving key debates on the diversification, physiology, biomechanics and phylogenetic relationships of early gnathostomes.
Droplet Controlled Growth Dynamics in Molecular Beam Epitaxy of Nitride Semiconductors
Authors: Azadmand Mani , Barabani Luca , Bietti Sergio , Chrastina Daniel , Bonera Emiliano , Acciarri Maurizio , Fedorov Alexey , Tsukamoto Shiro , Nötzel Richard , Sanguinetti Stefano 
Published: July 2018

AbstractThe growth dynamics of Ga(In)N semiconductors by Plasma-Assisted Molecular Beam Epitaxy (PAMBE) at low temperatures (T = 450 °C) is here investigated. The presence of droplets at the growth surface strongly affects the adatom incorporation dynamics, making the growth rate a decreasing function of the metal flux impinging on the surface. We explain this phenomenon via a model that considers droplet effects on the incorporation of metal adatoms into the crystal. A relevant role is played by the vapor-liquid-solid growth mode that takes place under the droplets due to nitrogen molecules directly impinging on the droplets. The role of droplets in the growth dynamics here observed and modeled in the case of Nitride semiconductors is general and it can be extended to describe the growth of the material class of binary compounds when droplets are present on the surface.
Stratifying ocean sampling globally and with depth to account for environmental variability
Authors: Costello Mark John , Basher Zeenatul , Sayre Roger , Breyer Sean , Wright Dawn J. 
Published: July 2018

AbstractWith increasing depth, the ocean is less sampled for physical, chemical and biological variables. Using the Global Marine Environmental Datasets (GMED) and Ecological Marine Units (EMUs), we show that spatial variation in environmental variables decreases with depth. This is also the case over temporal scales because seasonal change, surface weather conditions, and biological activity are highest in shallow depths. A stratified sampling approach to ocean sampling is therefore proposed whereby deeper environments, both pelagic and benthic, would be sampled with relatively lower spatial and temporal resolutions. Sampling should combine measurements of physical and chemical parameters with biological species distributions, even though species identification is difficult to automate. Species distribution data are essential to infer ecosystem structure and function from environmental data. We conclude that a globally comprehensive, stratification-based ocean sampling program would be both scientifically justifiable and cost-effective.
Estrogen Action in the Epithelial Cells of the Mouse Vagina Regulates Neutrophil Infiltration and Vaginal Tissue Integrity
Authors: Li Shuai , Herrera Gerardo G. , Tam Keila K. , Lizarraga Jacob S. , Beedle My-Thanh , Winuthayanon Wipawee 
Published: July 2018

AbstractIn the female reproductive tract, the innate immune system is modulated by two sex steroid hormones, estrogen and progesterone. A cyclical wave of neutrophils in the vaginal lumen is triggered by chemokines and correlates with circulating estrogen levels. Classical estrogen signaling in the female reproductive tract is activated through estrogen receptor α (encoded by the Esr1 gene). To study the role of estrogen action in the vagina, we used a mouse model in which Esr1 was conditionally ablated from the epithelial cells (Wnt7acre/+; Esr1f/f). Histological evidence showed that in response to a physical stress, the lack of ESR1 caused the vaginal epithelium to deteriorate due to the absence of a protective cornified layer and a reduction in keratin production. In the absence of ESR1 in the vaginal epithelial tissue, we also observed an excess of neutrophil infiltration, regardless of the estrous cycle stage. The histological presence of neutrophils was found to correlate with persistent enzymatic activity in the cervical-vaginal fluid. Together, these findings suggest that ESR1 activity in the vaginal epithelial cells is required to maintain proper structural integrity of the vagina and immune response, both of which are necessary for protecting the vagina against physical damage and resetting the vaginal environment.
Generation of reconfigurable optical traps for microparticles spatial manipulation through dynamic split lens inspired light structures
Authors: Lizana Angel , Zhang Haolin , Turpin Alex , Van Eeckhout Albert , Torres-Ruiz Fabian A. , Vargas Asticio , Ramirez Claudio , Pi Francesc , Campos Juan 
Published: July 2018

AbstractWe present an experimental method, based on the use of dynamic split-lens configurations, useful for the trapping and spatial control of microparticles through the photophoretic force. In particular, the concept of split-lens configurations is exploited to experimentally create customized and reconfigurable three-dimensional light structures, in which carbon coated glass microspheres, with sizes in a range of 63–75 μm, can be captured. The generation of light spatial structures is performed by properly addressing phase distributions corresponding to different split-lens configurations onto a spatial light modulator (SLM). The use of an SLM allows a dynamic variation of the light structures geometry just by modifying few control parameters of easy physical interpretation. We provide some examples in video format of particle trapping processes. What is more, we also perform further spatial manipulation, by controlling the spatial position of the particles in the axial direction, demonstrating the generation of reconfigurable three-dimensional photophoretic traps for microscopic manipulation of absorbing particles.
Enduring Lagrangian coherence of a Loop Current ring assessed using independent observations
Authors: Beron-Vera Francisco J. , Olascoaga María J. , Wang Yan , Triñanes Joaquín , Pérez-Brunius Paula 
Published: July 2018

AbstractOcean flows are routinely inferred from low-resolution satellite altimetry measurements of sea surface height assuming a geostrophic balance. Recent nonlinear dynamical systems techniques have revealed that surface currents derived from altimetry can support mesoscale eddies with material boundaries that do not filament for many months, thereby representing effective transport mechanisms. However, the long-range Lagrangian coherence assessed for mesoscale eddy boundaries detected from altimetry is constrained by the impossibility of current altimeters to resolve ageostrophic submesoscale motions. These may act to prevent Lagrangian coherence from manifesting in the rigorous form described by the nonlinear dynamical systems theories. Here we use a combination of satellite ocean color and surface drifter trajectory data, rarely available simultaneously over an extended period of time, to provide observational evidence for the enduring Lagrangian coherence of a Loop Current ring detected from altimetry. We also seek indications of this behavior in the flow produced by a data-assimilative system which demonstrated ability to reproduce observed relative dispersion statistics down into the marginally submesoscale range. However, the simulated flow, total surface and subsurface or subsampled emulating altimetry, is not found to support the long-lasting Lagrangian coherence that characterizes the observed ring. This highlights the importance of the Lagrangian metrics produced by the nonlinear dynamical systems tools employed here in assessing model performance.
High-contrast switching and high-efficiency extracting for spontaneous emission based on tunable gap surface plasmon
Authors: Hao He , Ren Juanjuan , Duan Xueke , Lu Guowei , Khoo Iam Choon , Gong Qihuang , Gu Ying 
Published: July 2018

AbstractControlling spontaneous emission at optical scale lies in the heart of ultracompact quantum photonic devices, such as on-chip single photon sources, nanolasers and nanophotonic detectors. However, achiving a large modulation of fluorescence intensity and guiding the emitted photons into low-loss nanophotonic structures remain rather challenging issue. Here, using the liquid crystal-tuned gap surface plasmon, we theoretically demonstrate both a high-contrast switching of the spontaneous emission and high-efficiency extraction of the photons with a specially-designed tunable surface plasmon nanostructures. Through varying the refractive index of liquid crystal, the local electromagnetic field of the gap surface plasmon can be greatly modulated, thereby leading to the swithching of the spontaneous emission of the emitter placed at the nanoscale gap. By optimizing the material and geometrical parameters, the total decay rate can be changed from 103γ0 to 8750γ0, [γ0 is the spontaneous emission rate in vacuum] with the contrast ratio of 85. Further more, in the design also enables propagation of the emitted photons along the low-loss phase-matched nanofibers with a collection efficiency of more than 40%. The proposal provides a novel mechanism for simultaneously switching and extracting the spontaneous emitted photons in hybrid photonic nanostructures, propelling the implementation in on-chip tunable quantum devices.
Analysis of the genotype-phenotype correlation in patients with phenylketonuria in mainland China
Authors: Li Nana , He Chunhua , Li Jing , Tao Jing , Liu Zhen , Zhang Chunyan , Yuan Yuan , Jiang Hui , Zhu Jun , Deng Ying , Guo Yixiong , Li Qintong , Yu Ping , Wang Yanping 
Published: July 2018

AbstractMutations in the gene encoding phenylalanine hydroxylase (PAH) are associated with various degrees of phenylketonuria (PKU). The aim of our study was to define the genotype-phenotype correlations of mutations in the PAH gene that cause phenylketonuria (PKU) among the Chinese mainland population. Mutations in the PAH gene were analysed by next-generation sequencing, and a genotype-phenotype correlation analysis was performed in 1079 patients. Fifteen “null + null” genotypes, including four homoallelic and eleven heteroallelic genotypes, were clearly associated with classic PKU. Five functionally hemizygous (p.E280K, p.R252Q, p.E56D, p.S310F and p.T372R) and four compound heterozygous (p.T278I/p.S359L, p.R408W/p.R243Q, p.F161S/p.R243Q and p.F161S/p.R413P) genotypes were clearly associated with classic PKU. Ten functionally hemizygous genotypes, p.G257V, p.R158W, p.L255S, p.G247V, p.F161S, p.R158Q, p.V388M, p.I65T, p.I324N and p.R400K, were frequently associated with classic PKU. Three functionally hemizygous genotypes, p.P147L, p.I95del and p.F331S, and four compound heterozygous genotypes, p.G257V/p.R408Q, p.A434D/p.R413P, p.R243Q/p.A47E and p.R241C/p.G239D, were consistently correlated with mild PKU. Three functionally hemizygous genotypes, p.H107R, p.Q419R and p.F392I, and nine compound heterozygous genotypes (p.G312V/p.R241C, p.R243Q/p.V230I, p.R243Q/p.A403V, p.R243Q/p.Q419R, p.R243Q/p.R53H, p.R243Q/p.H107R, p.R241C/p.R408Q, p.R241C/p.H220P and p.R53H/p.R400K) were consistent with mild hyperphenylalaninaemia (MHP). Our study provides further support for the hypothesis that the PAH genotype is the main factor that determines the phenotype of PKU.
First principles calculation of the nonhydrostatic effects on structure and Raman frequency of 3C-SiC
Authors: Lei Liu , Li Yi , Hong Liu , Ying Li , Chun-Qiang Zhuang , Long-Xing Yang , Gui-Ping Liu 
Published: July 2018

AbstractFor understanding the quantitative effect of nonhydrostatic stress on properties of material, the crystal structure and Raman spectra of 3C-SiC under hydrostatic and nonhydrostatic stress were calculated using a first-principles method. The results show that the lattice constants (a, b, and c) under nonhydrostatic stresses deviate those under hydrostatic stress. The differences of the lattice constants under hydrostatic stress from nonhydrostatic stresses with differential stress were fitted by linear equation. Nonhydrostatic stress has no effect on density of 3C-SiC at high pressure, namely the equations of state of 3C-SiC under hydrostatic stress are same as those under nonhydrostatic stress. The frequencies and pressure dependences of LO and TO modes of 3C-SiC Raman spectra under nonhydrostatic stress are just same as those under hydrostatic stress. Under nonhydrostatic stress, there are four new lines with 361, 620, 740, and 803 cm−1 appeared in the Raman spectra except for the LO and TO lines because of the reduction of structure symmetry. However the frequencies and pressure dependences of the four Raman modes remain unchanged under different nonhydrostatic stresses. Appearance of new Raman modes under nonhydrostatic stress and the linear relationship of the differences of lattice constants under hydrostatic and nonhydrostatic stresses with differential stress can be used to indicate state of stress in high pressure experiments. The effect of nonhydrostatic stress on materials under high pressure is complicated and our calculation would help to understanding state of stress at high pressure experiments.
Effective lagrangian for axial anomaly and its applications in Dirac and Weyl semimetals
Authors: Chen Chih-Yu , Hu C. D. , Lin Yeu-Chung 
Published: July 2018

AbstractA gauge invariant effective lagrangian for the fermion axial anomaly is constructed. The dynamical degree of freedom for fermion field is preserved. Using the anomaly lagrangian, the scattering cross section of pair production γγ → e−e+ in Dirac or Weyl semimetal is computed. The result is compared with the corresponding result from Dirac lagrangian. It is found that anomaly lagrangain and Dirac lagrangian exhibit the same E ⋅ B pattern, therefore the E ⋅ B signature may not serve a good indicator of the existence of axial anomaly. Because anomaly generates excessive right-handed electrons and positrons, pair production can give rise to spin current by applying gate voltage and charge current with depositing spin filters. These experiments are able to discern genuine anomaly phenomena.
Automated analysis of lipid drug-response markers by combined fast and high-resolution whole cell MALDI mass spectrometry biotyping
Authors: Weigt David , Sammour Denis A. , Ulrich Timon , Munteanu Bogdan , Hopf Carsten 
Published: July 2018

AbstractRecent advances in matrix-assisted laser desorption/ionization (MALDI) mass spectrometry have enabled whole cell-MALDI mass spectrometry biotyping of drug-treated cultured cells for rapid monitoring of known abundant pharmacodynamic protein markers such as polyacetylated histones. In contrast, generic and automated analytical workflows for discovery of such pharmacodynamic markers, in particular lipid markers, and their use in cellular tests of drug-like compounds are still lacking. Here, we introduce such a workflow and demonstrate its utility for cellular drug-response monitoring of BCR-ABL tyrosine kinase inhibitors in K562 leukemia cells: First, low-molecular mass features indicating drug responses are computationally extracted from groups of MALDI-TOF mass spectra. Then, the lipids/metabolites corresponding to these features are identified by MALDI-Fourier transformation mass spectrometry. To demonstrate utility of the method, we identify the potassium adduct of phosphatidylcholine PC(36:1) as well as heme B, a marker for erythroid differentiation, as markers for a label-free MALDI MS-based test of cellular responses to BCR-ABL inhibitors. Taken together, these results suggest that MALDI-TOF mass spectrometry of lipids and other low molecular mass metabolites could support cell-based drug profiling.
Positive Platinum anomalies at three late Holocene high magnitude volcanic events in Western Hemisphere sediments
Authors: Tankersley Kenneth Barnett , Dunning Nicholas P. , Owen Lewis A. , Huff Warren D. , Park Ji Hoon , Kim Changjoo , Lentz David L. , Sparks-Stokes Dominique 
Published: July 2018

AbstractChanges in the global atmospheric budget of platinum reportedly correspond to explosive volcanic eruptions. Using inductively coupled plasma mass spectrometry (ICP-MS) elemental analysis we examined eight widely separated stratified sites to evaluate the geographic extent of three late Holocene high magnitude volcanic events. We found characteristic Pt anomalies across the Western Hemisphere dating to the Laki, Iceland (CE 1783–1784), Kuwae, Vanuatu (CE 1452–1453), and Eldgjá, Iceland (CE 934) explosive volcanic eruptions. Pt anomalies in sediments over a broad geographic area indicate distinctive time-correlative atmospheric deposition rates of platinum-rich volcanic ash. These anomalies provide new chronostratigraphic markers for these late Holocene high magnitude volcanic eruptions, which are especially valuable in the Western Hemisphere in strata with limited chronometric control. Pt anomalies provide an important tracer for the age of these volcanic events and ultimately a new chronostratigraphic marker in archaeological, geological, palynological, and paleontological sediments.
Nachbehandlung einer komplizierten Knieverletzung – ein Fallbeispiel
Authors: Bakodi René 
Published: July 2018

ZusammenfassungErik hat sich eine komplizierte Verletzung am Knie zugezogen. Drei verschiedene Strukturen sind betroffen, von denen jede für sich ein bestimmtes
Nachbehandlungsschema erfordert. Wie Erik dennoch eine gute Funktion innerhalb der ersten drei postoperativen Monate erreicht, erläutert René Bakodi.
Behandlung einer Patientin mit möglicher Frozen Shoulder auf sichere und einfache Weise (KISS)
Authors: Westerhuis Pieter 
Published: July 2018

ZusammenfassungDie klassischen Symptome der Frozen Shoulder sind Steifigkeit und Schmerzen in der Schulter.Bei der hier vorgestellten 60-jährigen Patientin manifestierten sich bei Schulterbewegungen hauptsächlich Bewegungseinschränkungen und kaum Schmerzempfindungen.Dieser Fallbericht beschreibt einen pragmatischen und realistischen Behandlungsansatz sowie den Clinical-Reasoning-Prozess bei Frozen-Shoulder-Syndrom.