bluuebunny/crossref_metadata_2025_split huggingface dataset:
Healthy lifestyle consultation based on traditional Chinese medicine versus routine patient education in the treatment of idiopathic sudden sensorineural hearing loss after failure of systemic therapy: Study protocol for a clinical randomised trial
Authors: Fei Yingping , Zheng Yun , Lai Dan , Zhong Ping , Lu Jing-zhe , Li Gang , Liu Peng 
Published: September 2019

Abstract
Background: Idiopathic sudden sensorineural hearing loss (ISSNHL) is an important cause of deafness. Despite the advances in systemic therapy, some cases of ISSNHL are untreated, because the exact ISSNHL aetiology is unclear . Traditional Chinese medicine (TCM) has been used for treating diseases for thousands of years and is popular and widely practic ed in Asia. TCM includes guidance on healthy lifestyle. In recent decades, the relationship between lifestyle and disease has been emphasised. Moreover, an unhealthy lifestyle may lead to illnesses . Thus, this study aims to compare the efficacy of lifestyle modification based on TCM with the usual consultation of ISSNHL after failure of a 2 weeks systemic therapy to provide a scientific basis for clinical decisions.

Methods: This study is a clinical randomised trial that involves 56 patients diagnosed with ISSNHL but with incomplete recovery after initial management (at least 2 weeks routine Western medical treatment). The study is performed in accordance with the sudden hearing loss clinical guideline of the American Academy of Otolaryngology – Head and Neck Surgery , which is published in 2012 . Participants are randomly distributed into two groups, namely, the healthy lifestyle modification group based on TCM and the control group (1:1 ratio). Patient follow-up lasted for 3 months. The primary outcome measure is the effective rate of hearing improvement, which is defined as the proportion of patients with at least 15 dB improvement in the average thresholds by the hearing loss frequency . The secondary outcome measures are the improvements in word recognition score, tinnitus handicap inventory for tinnitus and visual analogue scale for ear blockage and dizziness. Assessments are made at baseline after lifestyle modification for 1 and 3 months.

Discussion: The efficacy of healthy lifestyle modification based on a TCM programme for patients with ISSNHL with incomplete recovery after failure of initial systemic therapy is determined in this trial. Positive results provide clinica l evidence on the effects of TCM - based healthy lifestyle, which could be recommended as salvage therapy for patients with ISSNHL.
A novel miniature transposon-like element discovered in the coding sequence of a gene that encodes for 5-formyltetrahydrofolate in wheat
Authors: Domb Katherine , Keidar-Friedman Danielle , Kashkush Khalil 
Published: September 2019

Abstract
Background: Transposable elements (TEs) comprise over 80% of the wheat genome and usually possess unique features for specific super-families and families. However, the role of TEs in wheat evolution and reshaping the wheat genome remains largely unclear. Results: In this study, we discovered a miniature (307 bp in length) TE-like sequence in exon 6 of a gene that encodes for 5-formyltetrahydrofolate, in two accessions of wild emmer wheat (T. turgidum ssp. dicoccoides) and has interfered with the gene translation by creating a shorter reading frame as a result of a stop codon. The sequence that was termed Mariam, does not show any structural similarity to known TEs. It does not possess terminal inverted repeats (TIRs) that would allow us to assign this element to one of the TIR DNA super-families, and it does not possess characteristic features of SINE, such as a Pol-III promotor or a poly-A tail. In-silico analysis of five publicly available genome drafts of Triticum and Aegilops species revealed that Mariam element appears in a very low copy number (1- 3 insertions) in diploid wheat species and ~12 insertions in tetraploid and hexaploidy wheat species. In addition, Mariam element was found to be unique to wheat, as it was not found in other plant genomes. The dynamic nature of Mariam in the wheat genome was assessed by site-specific PCR analysis and revealed that it retained activity in wild emmer populations in a population-specific manner.
Conclusions: This study provides additional insight into the evolutionary impact of TEs in wheat.
Olmesartan Associated Enteropathy: Usefulness of Video Capsule Endoscopy in a Case With Doubtful Upper Endoscopic/Histological Picture
Authors: Abbruzzi Francesco , Loconte Ilaria , Carparelli Sonia , Ierardi Enzo , Di Leo Alfredo , Principi Mariabeatrice 
Published: September 2019

Background:
Olmesartan, an antihypertensive drug, may be associated with a severe
“sprue-like enteropathy”.

Objectives:
To report a case of Olmesartan enteropathy demonstrated by video capsule endoscopy
distally from the second duodenum along with the whole small bowel before and after drug withdrawal.

Case Presentation:
A 81-years-old man was referred for asthenia, chronic watery diarrhea and anasarca
(ascites, pleural effusion and edemas of superior and inferior limb). The only comorbidity was
hypertension treated with Olmesartan. All causes of infective and inflammatory chronic diarrhea
were investigated and excluded. Upper endoscopy was normal; histological examination of the second
portion of the duodenum showed moderate and patchy infiltration of lymphocytes at mucosal
and intra-epithelial level with intermittent partial villous atrophy. The possibility of adverse drug
reaction, estimated by Naranjo scale, showed a score of 7, indicating a strong probability. Olmesartan
was then withdrawn. However, because of severe clinical general condition, we preferred to corroborate
our diagnostic work-up by a non-invasive investigation, i.e. video capsule endoscopy,
which showed jejunal and ileal mucosal alterations (mosaic pattern, diffuse hyperemia, severe edema,
consequent apparent reduced lumen, diffuse thickening of intestinal folds, multiple erosions,
patchy lymphangectasia). After 14 days, the resolution of anasarcatic state and hydroelectrolytic
imbalances was observed. Nine months later, small-bowel video-capsule demonstrated mild mucosal
hyperaemia and mosaic pattern.

Conclusions:
Our case could give new insights in the field of Olmesartan associated enteropathy by
highlighting the possibility of distally main lesion location and, therefore, the usefulness of video
capsule endoscopy in the presence of doubtful diagnostic features.
Aktivitas Sitotoksik Fraksi Heksana Terung Pokak (Solanum torvum) terhadap Sel Kanker T47D
Authors: Helilusiatiningsih Nunuk , Yunianta Yunianta , Harijono Harijono , Widjanarko Simon Bambang , Sujuti Hidayat 
Published: September 2019

Terung pokak adalah tanaman dari genus Solanum yang diperkirakan memiliki sifat antikanker. Tujuan penelitian ini menganalisis kandungan dan aktivitas sitotoksik fraksi heksana terung pokak terhadap sel kanker T47D secara invitro. Uji identifikasi senyawa pada fraksi heksana terung pokak menggunakan uji kualitatif dengan penapisan fitokimia danÂ (Gas Chromatography-Mass Spectometry), uji sitotoksik menggunakan metode MTT, uji siklus sel kanker T47D dan apoptosis menggunakan metode flowcytometry.Â Hasil uji fitokimia menunjukkan terung pokakÂ mengandung alkaloid, saponin, glikosida dan steroid.Â Hasil uji identifikasi kimia fraksi heksanaÂ terung pokak menunjukkan 29 komponen yaitu asam asetat, asam propionat, 2- pentenal, 2- metilfuran, 1- penten-3-on, asam butirat, 2 -metilbutan, 2,3 butanedion, dimetil disuksipirazin, lfida, asam valerat, furfural, 3- heksanon, metional, heksanal, benzaldehid, 2-heptenal, 4- heptenal, 1,5 - octadien 3-on, 2- butilfuran, 3,5- oktadien-2- on, 1 okten-3-on, 2-pentilfuran, 2,6-nonadienal, 2- nonenal, 2- Isopropil-3-metoksipirazin, linalool, 2- isobutil metoksipirazin, dekalakton. Fraksi heksana terung pokak bersifat sitotoksik terhadap sel kanker T47DÂ dengan IC50 sebesarÂ 85,58Âµg/mL. Fraksi heksana terung pokak dapat menghambat siklus sel T47D pada fase G0-G1 sebesar 35,84%, fase S 27,05%, fase G2-M 37,46% dari pengamatan 20.000 sel T47D . Fraksi heksana terung pokak dapat memacu apoptosis awal sebesar 28,89% dan apoptosis akhirÂ 1,04% dari pengamatan 20.000 sel T47D.Â Hasil tersebut menunjukkan bahwaÂ fraksi heksana terung pokak bersifat sitotoksik, menghambat proliferasi dan memacu apoptosis sel T47D, sehingga layak dikembangkanÂ sebagai antikanker.
Transformasi Identitas Mahasiswa-Santri (Studi Fenomenologi Perubahan Identitas Mahasiswa STAIN Purwokerto Program 'Pesantrenisasi' Tahun Akademik 2013-2014)
Authors: Uswatusolihah Uus 
Published: September 2019

Abstract: This study was aimed at knowing the transformation of identity amongstudents joining Pesantrenisasi Program in State College on Islamic Studies ofPurwokerto in the academic year 2013-2014. This study explored their own perceptionof being a student of the college and a santri. This is a qualitative research withinterviews as the main method of collecting data. A number of students wereinterviewed to get the answers of research questions. This research found thatpesantrenisasi program is successful in making closed relationship betweenstudent and pesantren (Islamic boarding school). The life in pesantren has madesome students transform their identity. The transformation happens gradually andslowly through unspontaneous self-dialogue. This transformation also gives them anew self-image, a new self-language, and new relationships with others as well asnew bounds with social norms. Before living in a pesantren, they imagine pesantrenas a dirty, massy, strict, and fully scheduled place of living. This image graduallychanges after they experience themselves living in pesantren. A new image comesto them that pesantren is an ideal place to study religious knowledge, to train aperson to be mature and having good character, and to perform more worship toGod. Some of the transformations include the quantity and quality of their worship aswell as their attitude and behavior to be more discipline, independent, and humble.Keywords: identity transformation, students, pesantren.
Abstrak: Hasil penelitian ini adalah bahwa program pesantrenisasi telahberhasil mendekatkan mahasiswa dengan kehidupan pesantren dan menyebabkanterjadinya perubahan atau transformasi identitas diri sebagian mahasiswa.Transformasi itu sendiri pada umumnya berjalan secara perlahan dan melaluiproses-proses perenungan dan dialog diri yang tidak spontan. Transformasi jugamembuat mereka memperoleh citra diri yang baru, bahasa diri yang baru,hubungan-hubungan yang baru dengan orang-orang lain dan ikatan-ikatan yangbaru dengan tatanan sosial. Sebelum tinggal di pondok pesantren, mereka mendefinisikandunia pesantren adalah tempat yang kumuh, tidak rapi, memiliki banyakperaturan yang mengekang. Definisi ini berubah selama mereka berada di
pesantren: Pondok pesantren adalah tempat yang ideal untuk menuntut berbagaiilmu agama, melatih diri menjadi lebih dewasa dan berkarakter yang baik sertamemperbanyak ibadah seraya mendekatkan diri kepada Allah SWT. Beberapaperubahan terjadi dalam kuantitas dan kualitas ibadah, perubahan dalam sikapdan perilaku yang lebih disiplin, mandiri dan sederhana, serta peningkatanpengetahuan berbagai ilmu agama Islam.Keywords: perubahan identitas, mahasiswa, pesantren.
PENERAPAN MODEL PEMBELAJARAN COURSE REVIEW HORAY UNTUK MENINGKATKAN HASIL BELAJAR SISWA MATERI SISTEM KLASIFIKASI MAKHLUK HIDUP PADA KELAS X SMA NEGERI 14 AMBON
Authors: Tulaseket Christin , Leiwakabessy F , Rumahlatu Dominggus 
Published: September 2019

Background: This study aims to determine the effect of the application of the learning model of the horay course review to improve student learning outcomes of teaching material on the classification system of living things in class X of SMA Negeri 14 Ambon.
Method: Samples from this study were students of class X1 with 23 students. This type of research is descriptive research to see student learning outcomes which consists of 3 factors, namely physical, cognitive and psychomotor. The instruments used in this study were test instruments in the form of initial tests and final tests.
Results: The results of this study show that there is a significant effect by using the learning review horay learning model on improving student learning outcomes during the implementation of the learning model of the course review horay.
Conclusion: Based on the results of the study it can be concluded that the use of the Course Review Horay learning model can improve the learning outcomes of class X1 students at SMA Negeri 14 Ambon. This can be seen from the results of the final test which is very satisfying from the results of the initial test. Presentation of student grades during the initial test is 13% and the final test score reaches 100%.
ТВОРЧІСТЬ ВІКТОРА ЄФИМЕНКА В КОНТЕКСТІ РОЗВИТКУ УКРАЇНСЬКОЇ КНИЖКОВОЇ ГРАФІКИ (остання третина ХХ ст.)
Authors: Спасскова О. П. 
Published: September 2019

The purpose of the work is to study the creativity of the Odessa graphic artist Viktor Efimenko (1933-1994) in the context of the development of Ukrainian book graphics of the last third of the twentieth century. The method The basis of our research is the historical-cultural, comparative-typological and figurative-stylistic research methods, which made it possible to achieve a holistic analysis of the graphic works of V. Efimenko. The main thing is the art history analysis of works of book and easel graphic. The last third of the twentieth century is marked by changes in the cultural life of the country. Ukrainian artists sought to join the European and world trends in artistic development, which was characterized by a variety of styles and methods. Despite the fact that state requirements and standards were of great importance, the artists tried to put in to practice the socially relevant topics of concern to them. Two directions of the master's creativity are considered: book and easel illustration. The relationship between the individual graphic style of V. Efimenko and the general artistic process is considered. On the basis of the artistic and stylistic analysis, the interrelation of V. Efimenko’s creativity with the Ukrainian and world artist revealed. It is revealed that the master's works are characterized by a deeply personal, philosophical reading of texts and their figurative reproduction in the language of graphics. It is noted that V. Efimenko could express his philosophical ideas thanks to his free possession of linocut and etching techniques.
Laparoscopic alloplasty of troacary hernia paraumbilically area
Authors: Feleshtynsky Ia.P. , Dadayan V. А. 
Published: September 2019

Currently, researchers continue to debate about the choice of surgical treatment for such hernias, which is more appropriate to use: classic laparoscopic alogioplasty or a modified laparoscopic alloplasty technique.
Objective. The scientific justification for the choice of surgical tactics and improve the results of surgical treatment of trocar hernias of the paraumbilical site and prove the effectiveness of the proposed method.
Materials and methods. The article presents the results of the analysis of surgical treatment of trocar abdominal hernias in 64 patients aged 30 to 75 years. During the analysis, we divided the patients into two groups equal in number of faces, the inclusion factor in the first group was classical laparoscopic alogioplasty (32 patients), and the second group included patients who underwent our modified surgery - laparoscopic alloplasty of postoperative trocar hernias paraumbilical plot.
Research results and discussion. When conducting a comparative analysis of the course of the early postoperative period in patients of the first group, we found that seroma was observed in 12.5% (4) patients, the second group – in 6.3% (2) patients. Postoperative wound infection was observed in only one (3.1%) patient of the first group. The length of stay of patients in the clinic, in the inpatient department, ranged from 7 to 2 days. Patients of the first group - 5 ± 2.12 (p <0.05) days, and patients of the second group - 2 ± 1.31 (p <0.05) days, respectively.
Findings. Therefore, we found that laparoscopic alloplasty of trocar hernias of the abdomen has significant advantages over open by reducing the frequency of postoperative complications by more than two times from the side of the wound. In addition, the length of stay of such patients in the surgical department is reduced by 2.5 times, which, in turn, significantly reduces costs. During the prospective observation of patients who underwent laparoscopic allogernioplasty of trocar abdominal hernias (within three years after the intervention), we can state that the elimination of the defect by the proposed method is not accompanied by relapse.
Ambulatory blood pressure monitoring changes in hypertensive patients
Authors: Pasko V.S. 
Published: September 2019

The aim of the study was to determine the peculiarities of ABPM indices in middle-aged and elderly hypertensive patients depending on the daily BP profile.
Material and methods. Indices of ambulatory blood pressure monitoring were identified in 57 middle-aged patients (45-59 years) (group I) and 43 elderly patients (60-74 years) (group II), who underwent two-week in-patient treatment. The control group consisted of 15 patients for every of the surveyed categories (group III - middle-aged and group IV – elderly respectively) matched with basic by age and gender.
Results. We have shown that one of the factors that determines the change in hemodynamics in patients with essential hypertension is age, with the age patients experience the decrease in diastolic blood pressure with steadily increased systolic blood pressure, that should be considered in the prescription of antihypertensive treatment. With age, a gradual increase in systolic blood pressure is associated with the increased aortic stiffness, partially with the increase in collagen and the decrease in elastic fibrils and the formation of isolated systolic hypertension. Thus, it is proved that in the formation of isolated hypertension the growth of pulse blood pressure for more than 60 mm Hg is unfavorable in a development of cerebrovascular events. Pulse arterial blood pressure was stronger risk factor than systolic blood pressure and diastolic blood pressure or average arterial pressure in the elderly. Recently, taking into account age characteristics, all three indices were recognized as comparable predictors at the age of 50-59 years as the transitional period, and at the age of 60-79 years diastolic blood pressure adversely affecting the cardiovascular risk, increased pulse blood pressure prognostically above the level of systolic arterial pressure.
ANALISIS ECONOMIC VALUE ADDED (EVA), FINANCIAL VALUE ADDED (FVA) DAN MARKET VALUE ADDED (MVA) DENGAN TIME SERIES APPROACH SEBAGAI ALAT PENILAIAN KINERJA KEUANGAN (Studi Pada Industri Konstruksi (BUMN) di Indonesia Yang Listing di BEI Tahun 2013-2017)
Authors: Sunardi Nardi 
Published: September 2019

ABSTRACTPenelitian ini bertujuan untuk mengetahu kinerja keuangan perusahaan Industri Konstruksi (BUMN) di Indonesia yang listing di Bursa Efek Indonesia Periode 2013-2017 dengan pendekatan Economic Value Added (EVA), Financial Value Added (FVA) dan Market Value Added (MVA) dengan Time Series Approach, Hasil penelitian ini menunjukkan bahwa Perusahaan PT.Adhi Karya (Persero)Tbk, PT.Wijaya Karya (Persero) dan PT. Waskita Karya (Persero) dengan nilai EVA adalah negatif ini berarti berkinerja tidak baik. sedangkan PT. PP (Persero) Tbk adalan positif berarti berkinerja baik, PT.Adhi Karya (Persero)Tbk, nilai rata-rata FVA adalah negatif berarti berkinerja tidak baik.. Sedangkan nilai rata-rata EVA pada PT. PP (Persero) Tbk, PT.Wijaya Karya (Persero), dan PT. Waskita Karya (Persero) adalan positif berarti berkinerja baik, PT.Adhi Karya (Persero)Tbk, PT. PP (Persero) Tbk, PT.Wijaya Karya (Persero), dan PT. Waskita Karya (Persero) nilai rata-rata MVA adalah negatif berarti berkinerja tidak baik,Kinerja keuangan perusahaan Konstruksi (BUMN) di Indonesia secara simutan sebesar 2,091 nunjukan hasill positif berarti berkinerja baik.
PENGARUH LINGKUNGAN KERJA DAN MOTIVASI KERJA TERHADAP KINERJA PEGAWAI PADA PT. SEGAR INDAH ABADI
Authors: Sahara Sahara , Pramana Reza 
Published: September 2019

Adanya keseimbangan antara lingkungan kerja dan Motivasi kerja dapat mempengaruhi kinerja pegawai. Kinerja pegawai adalah hasil kerja baik secara kualitas maupun kuantitas yang dihasilkan oleh pegawai dalam melaksanakan tugasnya sesuai dengan tanggung jawab yang diberikan kepadanya. Pegawai dapat bekerja dengan baik bila memiliki kinerja yang tinggi sehingga diharapkan tujuan organisasi dapat tercapai.
Tujuan yang ingin dicapai di dalam penelitian ini adalah untuk mengetahui pengaruh lingkungan kerja dan motivasi kerja terhadap kinerja pegawai pada PT. Segar Indah Abadi. Metode penelitian yang digunakan dalam penelitian ini adalah metode survey.
Hasil kesimpulan penelitian ini yaitu lingkungan kerja (X1) mempunyai pengaruh yang signifikan terhadap kinerja pegawai (Y) sebesar 2.117. Dimana dibuktikan dengan melihat nilai thitung variabel adalah lebih besar dari ttabel (2,117> 1,700). Motivasi kerja (X2) mempunyai pengaruh yang signifikan terhadap kinerja pegawai (Y) sebesar 2.920. Dimana dibuktikan dengan melihat nilai thitung variabel adalah lebih besar dari ttabel (2,920 > 1,700). Lingkungan kerja (X1) dan motivasi kerja (X2) secara simultan mempunyai pengaruh yang signifikan terhadap kinerja pegawai (Y) sebesar 28.022. Dimana dibuktikan dengan melihat nilai Fhitung variabel adalah lebih besar dari Ftabel (28,022 > 2,920).
Kata Kunci : Lingkungan kerja, Motivasi, Kinerja pegawai
Det farlige allmediet
Authors: Lome Ragnild 
Published: September 2019

En maskinstormerisk frykt, en forkjærlighet for dystopiske beretninger, blandet med en genuin nysgjerrighet på menneskets intrikate avhengighet av teknologi, kan spores i hele forfatterskapet til forfatteren og journalisten Nils Leijer; fra hans voldsomme og erotikkladede roman om den gryende bilkulturen i Bilburen (1963), satiren over de nye betingelsene i- og makten til reklamebransjen i Köpsugen (1965), til den SF-inspirerte Miniput (1968).
I sistnevnte roman tar den svenske forfatteren utgangspunkt i en dystopisk grunnfortelling, hvor menneskene er blitt for mange og overbelaster jordklodens ressurser. Mennesket beskrives som et begjærsdrevet vesen som «smutsar ner sin omgivning» (Leijer 1968: 16). For å overleve er menneskeheten nødt til å endre seg på et fundamentalt plan, og en forskningsbase opprettes, som arbeider med flere løsninger på overbefolkningsproblemet. En av løsningene, som romanen har fått navn etter, er å krympe menneskene til miniatyrer, kun 50 cm lange, for å forhindre at belastningen på jordens ressurser øker. Parallelt med dette igangsettes et storslagent simuleringseksperiment, hvor det man tenker på som menneskelig – kjærlighet og omsorg –, forsøkes forvandles til reproduserbar, og dermed også manipulerbar informasjon, som man kan bruke til å stimulere og manipulere mennesker til å handle mer forsvarlig. Miniput kan derfor leses som en roman om den teknologiske medieringen av det vi kaller det menneskelige, samtidig som romanen står trygt plassert i en klassisk modernitetskritikk av teknologien. Leijers roman uttrykker et paradoks: Teknologien er samtidig det som fjerner oss fra vår naturlige relasjon til hverandre og grunnlaget for det vi kaller menneskelig.
Det følgende er et forsøk på å kartlegge hvordan medieringen beskrives i romanen, dens relasjon til sin samtid, hvilke konsekvenser som følger av den nye teknologiske situasjonen som romanen fremtenker, og hva slags paradokser som skjuler seg i romanens tenkning om forholdet mellom teknologi og mennesket.