bluuebunny/crossref_metadata_2025_split huggingface dataset:
Chemometric approaches for discriminating manufacturers of Korean handmade paper using infrared spectroscopy
Authors: Lee Yong Ju , Won Seo Young , Park Seong Bin , Kim Hyoung-Jin 
Published: October 2024

Abstract
The objective of this study was to identify the manufacturer of Hanji, Korean handmade paper widely used in conservation science. To achieve this, machine learning models utilizing attenuated total reflectance–infrared spectroscopy (ATR–IR) were developed to assess the robustness and effectiveness of the computed models. Principal component analysis (PCA), partial least squares–discriminant analysis (PLS–DA), decision tree (DT), and k-NN models were constructed using IR spectral data, with the spectral region between 1800 and 1500 cm⁻1 identified as the critical input variable through Variable Importance in Projection (VIP) scores. The transformation of the obtained spectra into second derivative spectra proved beneficial in this key spectral region, leading to significant improvements in model performance. Additionally, the application of DBSCAN for outlier detection was effective in refining the dataset, further enhancing the performance of the models. Specifically, the k-NN model, when applied to the selected variables and preprocessed with the second derivative transformation, achieved an F1 score of 0.92. These findings underscore the importance of focusing on the 1800–1500 cm⁻1 spectral range and applying outlier detection techniques, such as DBSCAN, to enhance the robustness and accuracy of the Hanji classification models by eliminating the influence of atypical data points.
Large-fiber neuropathy in Parkinson’s disease: a narrative review
Authors: Kwon Eun Hae , Steininger Julia , Scherbaum Raphael , Gold Ralf , Pitarokoili Kalliopi , Tönges Lars 
Published: October 2024

Abstract
Background
Numerous studies reported a higher prevalence of polyneuropathy (PNP) in patients with Parkinson’s disease (PD) compared to the general population. Importantly, PNP symptoms can aggravate both motor and sensory disturbances in PD patients and negatively impact the disease course. Recent analyses indicate distinct PNP patterns in PD.

Main text
This review aims to provide an overview of the current insights into etiological factors, diagnostic methods, and management strategies of large fiber neuropathy in PD. Despite the higher prevalence, the causes of PNP in PD are still not fully understood. A genetic predisposition can underlie PNP onset in PD. Main research attention is focused on long-term levodopa exposure which is suggested to increase PNP risk by depletion of methylation cofactors such as vitamin B12 and accumulation of homocysteine that altogether can alter peripheral nerve homeostasis. Beyond a potential “iatrogenic” cause, alpha-synuclein deposition has been detected in sural nerve fibers that could contribute to peripheral neuronal degeneration as part of the systemic manifestation of PD. Whereas mild axonal sensory PNP predominates in PD, a considerable proportion of patients also show motor and upper limb nerve involvement. Intriguingly, a correlation between PNP severity and PD severity has been demonstrated. Therefore, PNP screening involving clinical and instrument-based assessments should be implemented in the clinical routine for early detection and monitoring. Given the etiological uncertainty, therapeutic or preventive options remain limited. Vitamin supplementation and use of catechol-O-methyltransferase-inhibitors can be taken into consideration.

Conclusion
PNP is increasingly recognized as a complicating comorbidity of PD patients. Long-term, large-scale prospective studies are required to elucidate the causative factors for the development and progression of PD-associated PNP to optimize treatment approaches. The overall systemic role of “idiopathic” PNP in PD and a putative association with the progression of neurodegeneration should also be investigated further.
Functional response and control potential of adult
Arma chinensis
on Colorado potato beetle in Xinjiang, China
Authors: Liu Juan , Liao Jianghua , Li Chao 
Published: October 2024

Abstract

Potato is an important food crop. The Colorado potato beetle (CPB) is its key pest. CPBs are now resistant to several chemical pesticides, making their control more difficult. The predatory insect,
Arma chinensis
, is a natural enemy of other plant pests. We studied the predation of adult
A. chinensis
on CPB eggs and young larvae under indoor controlled conditions and its control of CPB in cages under outdoor conditions. Adult
A. chinensis
effectively reduces CPB egg and larva populations, and its predatory functional response aligns with Holling’s Type II model.
A. chinensis
adults released within outdoor cages reduced CPB populations. Based on the predation behavior of the adults of
A. chinensis
to CPB eggs and young larvae,
A. chinensis
is an efficient and potential predator.
Equal, equitable or exacerbating inequalities: patterns and predictors of social prescribing referrals in 160 128 UK patients
Authors: Bu Feifei , Hayes Daniel , Burton Alexandra , Fancourt Daisy 
Published: October 2024

Background
Social prescribing is growing rapidly globally as a way to tackle social determinants of health. However, whom it is reaching and how effectively it is being implemented remains unclear.

Aims
To gain a comprehensive picture of social prescribing in the UK, from referral routes, reasons, to contacts with link workers and prescribed interventions.

Method
This study undertook the first analyses of a large database of administrative data from over 160 000 individuals referred to social prescribing across the UK. Data were analysed using descriptive analyses and regression modelling, including logistic regression for binary outcomes and negative binomial regression for count variables.

Results
Mental health was the most common referral reason and mental health interventions were the most common interventions prescribed. Between 72% and 85% of social prescribing referrals were from medical routes (primary or secondary healthcare). Although these referrals demonstrated equality in reaching across sociodemographic groups, individuals from more deprived areas, younger adults, men, and ethnic minority groups were reached more equitably via non-medical routes (e.g. self-referral, school, charity). Despite 90% of referrals leading to contact with a link worker, only 38% resulted in any intervention being received. A shortage of provision of community activities – especially ones relevant to mental health, practical support and social relationships – was evident. There was also substantial heterogeneity in how social prescribing is implemented across UK nations.

Conclusions
Mental health is the leading reason for social prescribing referrals, demonstrating its relevance to psychiatrists. But there are inequalities in referrals. Non-medical referral routes could play an important role in addressing inequality in accessing social prescribing and therefore should be prioritised. Additionally, more financial and infrastructural resource and strategic planning are needed to address low intervention rates. Further investment into large-scale data platforms and staff training are needed to continue monitoring the development and distribution of social prescribing.
Dynamic protein assembly and architecture of the large solitary membraneless organelle during germline development in the wasp Nasonia vitripennis
Authors: Kharel Kabita , Tindell Samuel J. , Kemph Allie , Schmidtke Ryan , Alexander Emma , Lynch Jeremy A. , Arkov Alexey L. 
Published: October 2024

ABSTRACT
Throughout metazoa, germ cells assemble RNA-protein organelles (germ granules). In Drosophila ovaries, perinuclear nuage forms in the nurse cells, while compositionally similar polar granules form in the oocyte. A similar system appears to exist in the distantly related (∼350 million years) wasp Nasonia, with some surprising divergences. Nuage is similarly formed in Nasonia, except that anterior nurse cells accumulate significantly more nuage, in association with high levels of DNA double-strand breaks, suggesting that increased transposon activity anteriorly is silenced by high nuage levels. In the oocyte, the germ plasm forms a single granule that is 40 times larger than a homologous Drosophila polar granule. While conserved germ granule proteins are recruited to the oosome, they show unusual localization: Tudor protein forms a shell encapsulating the embryonic oosome, while small Oskar/Vasa/Aubergine granules coalesce interiorly. Wasp Vasa itself is unusual since it has an alternative splice form that includes a previously unreported nucleoporin-like phenylalanine-glycine repeat domain. Our work is consistent with the high degree of evolutionary plasticity of membraneless organelles, and describes a new experimental model and resources for studying biomolecular condensates.
Back to the future – 20 years of progress and developments in photonic microscopy and biological imaging
Authors: Erard Marie , Favard Cyril , Lavis Luke D. , Recher Gaëlle , Rigneault Hervé , Sage Daniel 
Published: October 2024

ABSTRACT
In 2023, the ImaBio consortium (imabio-cnrs.fr), an interdisciplinary life microscopy research group at the Centre National de la Recherche Scientifique, celebrated its 20th anniversary. ImaBio contributes to the biological imaging community through organization of MiFoBio conferences, which are interdisciplinary conferences featuring lectures and hands-on workshops that attract specialists from around the world. MiFoBio conferences provide the community with an opportunity to reflect on the evolution of the field, and the 2023 event offered retrospective talks discussing the past 20 years of topics in microscopy, including imaging of multicellular assemblies, image analysis, quantification of molecular motions and interactions within cells, advancements in fluorescent labels, and laser technology for multiphoton and label-free imaging of thick biological samples. In this Perspective, we compile summaries of these presentations overviewing 20 years of advancements in a specific area of microscopy, each of which concludes with a brief look towards the future. The full presentations are available on the ImaBio YouTube channel (youtube.com/@gdrimabio5724).
Activation of the mitochondrial unfolded protein response regulates the dynamic formation of stress granules
Authors: Lopez-Nieto Marta , Sun Zhaozhi , Relton Emily , Safakli Rahme , Freibaum Brian D. , Taylor J. Paul , Ruggieri Alessia , Smyrnias Ioannis , Locker Nicolas 
Published: October 2024

ABSTRACT
To rapidly adapt to harmful changes to their environment, cells activate the integrated stress response (ISR). This results in an adaptive transcriptional and translational rewiring, and the formation of biomolecular condensates named stress granules (SGs), to resolve stress. In addition to this first line of defence, the mitochondrial unfolded protein response (UPRmt) activates a specific transcriptional programme to maintain mitochondrial homeostasis. We present evidence that the SG formation and UPRmt pathways are intertwined and communicate. UPRmt induction results in eIF2α phosphorylation and the initial and transient formation of SGs, which subsequently disassemble. The induction of GADD34 (also known as PPP1R15A) during late UPRmt protects cells from prolonged stress by impairing further assembly of SGs. Furthermore, mitochondrial functions and cellular survival are enhanced during UPRmt activation when SGs are absent, suggesting that UPRmt-induced SGs have an adverse effect on mitochondrial homeostasis. These findings point to a novel crosstalk between SGs and the UPRmt that might contribute to restoring mitochondrial functions under stressful conditions.
Comment on “Salesforce Compensation with Inventory Considerations”: A Rejoinder
Authors: Dai Tinglong , Jerath Kinshuk 
Published: October 2024

In this rejoinder, we address the concern about equilibrium existence in our previous work published in 2013. By making the simple adjustment of discretizing inventory ordering amounts to prevent inventory orders in arbitrarily small increments, we show that the results from that paper hold, thus maintaining the robustness of the insights obtained. This paper was accepted by Jeannette Song, operations management.
Resolution-enhanced quantitative phase imaging of blood platelets using a generative adversarial network
Authors: Luria Lior , Barnea Itay , Mirsky Simcha K. , Shaked Natan T. 
Published: October 2024

We developed a new method to enhance the resolution of blood platelet aggregates imaged via quantitative phase imaging (QPI) using a Pix2Pix generative adversarial network (GAN). First, 1 µm polystyrene beads were imaged with low- and high-resolution QPI, to train the GAN model and validate its applicability. Testing on the polystyrene beads demonstrated a mean error of 4.14% in the generated high-resolution optical-path-delay values compared to the optically acquired ones. Next, blood platelets were collected with low- and high-resolution QPI, and a deep neural network was trained to predict the high-resolution platelet optical-path-delay profiles using the low-resolution profiles, achieving a mean error of 7.01% in the generated high-resolution optical-path-delay values compared to the optically acquired ones. These results highlight the potential of the method in enhancing QPI resolution of cell aggregates without the need for sophisticated optical equipment and optical system modifications for high-resolution microscopy, allowing for better understanding of platelet-related disorders and conditions such as thrombocytopenia and thrombocytosis.
Mass azithromycin for prevention of child mortality among children with acute malnutrition: A subgroup analysis of a cluster randomized controlled trial
Authors: Sié Ali , Ouattara Mamadou , Bountogo Mamadou , Boudo Valentin , Ouedraogo Thierry , Dah Clarisse , Compaoré Guillaume , Lebas Elodie , Hu Huiyu , Porco Travis C. , Arnold Benjamin F. , O’Brien Kieran S. , Lietman Thomas M. , Oldenburg Catherine E. 
Published: October 2024

Children with acute malnutrition are at high risk of morality. Mass azithromycin distribution reduces all-cause mortality among children aged 1–59 months, and effects may be greater in underweight infants. Here, we evaluate the efficacy of azithromycin for reducing all-cause mortality in children aged 6–59 months with acute malnutrition (mid-upper arm circumference, MUAC, < 12.5 cm). Communities in Nouna District, Burkina Faso were 1:1 randomized to biannual mass distribution of single dose azithromycin or placebo to all children aged 1–59 months. Mortality was assessed during each census and treatment round. MUAC measurements were collected for all children. We evaluated the effect of azithromycin on mortality in subgroups of children aged 6–59 months defined by acute malnutrition (MUAC < 12.5 cm versus MUAC ≥ 12.5 cm). In children with MUAC < 12.5 cm, mortality rates were 51% lower among those living in azithromycin communities compared to placebo (incidence rate ratio 0.49, 95% confidence interval, CI, 0.25 to 0.99; incidence rate difference -18.1 deaths per 1,000 person-years, 95% CI -37.0 to -0.01), which was greater than the reduction in mortality among children with MUAC ≥ 12.5 cm (P-value for interaction on the relative scale = 0.09; P-value for interaction of the additive scale = 0.03). Children with acute malnutrition may benefit from single dose azithromycin above and beyond those without acute malnutrition.
Trial registration: ClinicalTrials.gov NCT03676764; https://clinicaltrials.gov/study/NCT03676764
Incidence and predictors of neuropsychiatric manifestations following a traumatic brain injury at referral hospitals in Dodoma, Tanzania: A protocol of a prospective longitudinal observational study
Authors: Aslan Suluma , Nyundo Azan 
Published: October 2024

Introduction
Traumatic Brain Injury (TBI) is any injury to the brain resulting from an external force leading to complications. TBI affects 27–69 million people yearly, with high incidence in low- and middle-income countries (LMICs), mainly attributed to motor traffic accidents. Within three to six months following moderate-to-severe TBI, the relative risk of any psychiatric disorder is significantly higher than in the general population. Post-TBI neuropsychiatric disorders include depression with a prevalence of up to 53%, apathy up to 72%, Posttraumatic stress disorder (26%), anxiety (9%), manic symptoms (5–9%) and psychosis (3 to 8%). This study aims to determine the incidence and predictors of post-TBI neuropsychiatric manifestations among patients admitted at Referral hospitals in Dodoma.

Methods and analysis
This is a prospective longitudinal observational study in which patients admitted with moderate to severe TBI will be recruited. Patients will be followed for six months, the diagnostic MINI International Neuropsychiatric Interview (MINI) tool will be used to assess TBI, and the severity and progression of symptoms will be evaluated using PHQ-9 for depressive symptoms, GAD-7 for anxiety symptoms, PCL-5 for Posttraumatic Stress Disorders (PTSD), MoCA for cognitive assessment, AES for apathy and YMRS for manic symptoms at one, three and six months. Logistic regression will be analysed to determine the association between predictors and neuropsychiatric outcomes.

Conclusion
Given the dearth of understanding of the burden of neuropsychiatric complications and associated outcomes in sub-Saharan Africa, the study will shed light on the incidence and factors contributing to post-TBI neuropsychiatric complications and, thus, provide a platform for further research and design of necessary interventional programs for the population at risk.
Associations of the TyG index with albuminuria and chronic kidney disease in patients with type 2 diabetes
Authors: Li Xiaonan , Wang Yuehui 
Published: October 2024

Objective
Diabetes-related kidney disease reduces patients’ quality of life, increases the risk of death, and is associated with insulin resistance (IR). The triglyceride-glucose (TyG) index is a simple and inexpensive alternative to IR measurement. Furthermore, the relationship between albuminuria and chronic kidney disease (CKD) in type 2 diabetes mellitus (T2DM) remains unclear. Therefore, we aimed to investigate the association of TyG index with albuminuria and CKD in patients with T2DM.

Methods
Data from 01/2013-12/2017 period were obtained from the Population Health Data Archive’s Diabetes Complications Data Set. A total of 1048 patients with T2DM were included in this study. CKD is defined as an estimated glomerular filtration rate < 60 ml/min-1.1.73 m-2 or a urinary albumin-to-creatinine ratio (UACR) ≥ 30 mg/g. Albuminuria is defined as a UACR ≥ 30 mg/g. The TyG index is calculated by measuring the triglyceride and fasting blood glucose levels. Logistic regression models were used to analyze the association between albuminuria, CKD with T2DM and TyG index.

Results
We identified 1048 subjects, 63.03% of whom were men. The mean age was 46.21 years, and the mean body mass index was 26.742 kg/m2. CKD and albuminuria detection rates showed an increasing trend in the different TyG subgroups. (p = 0.008, p = 0.006). Using the Q1 group as a baseline, the risk of albuminuria and CKD was significantly greater in the group Q3 (OR = 1.514, 95% CI 1.121–2.047 P = 0.05), and the same result was obtained after adjusting for covariates (OR = 2.241, 95% CI 1.245–4.034, P = 0.007). Subgroup analyses revealed a significant increase in the incidence of albuminuria and CKD in the group Q3 compared to that in the Q1 group.

Conclusions
The TyG index is positively associated with albuminuria and CKD in patients with T2DM and may be a marker for predicting the occurrence of early kidney injury in patients with T2DM. Clinicians should test this indicator early to detect lesions and improve patient prognosis.
Effect of sowing methods, spacings, and fertilizer levels on quantitative and qualitative traits and economics of brown top millet (Brachiaria ramosa L.) under different cropping seasons
Authors: Abhigna Dokka , Kalpana Rengabashyam , Geetha Padmanaban , Janaki Ponnusamy , Radhamani Sengodan , Ravichandran Veerasamy 
Published: October 2024

A field study was conducted during the Summer, Kharif, and Rabi seasons of 2023-2024 to evaluate brown top millet under two sowing methods (direct sowing and transplantation), three spacing configurations (20 x 10, 30 x 10 and 45 x 10 cm), and three fertilizer doses (75% of the recommended dose of fertilizer (RDF) (45:20:15 kg ha-1), 100% RDF (60:30:20 kg ha-1), and 125% RDF (75:40:25 kg ha-1)). The study was designed as a factorial randomized complete block design assessing growth, yield, thiamine content, and economics. The results indicated that the summer season was more favorable for growth than the Kharif and Rabi seasons. Direct sown crops (E1) exhibited significantly higher growth attributes, yield, and economics than transplanted crops (E2). The spacing configuration of 45 x 10 cm (S3) recorded significantly superior growth and yield parameters compared to 20 x 10 cm (S1). Applying 125% RDF (N3) resulted in significantly enhanced growth, yield, quality, and economic return compared to 75% RDF. Among the interactions, the combination of direct sown with narrow spacing and 125% RDF (E1 x S1 x N3) led to significantly higher growth parameters. In comparison, the combination of direct sowing with wider spacing and 125% RDF (E1 x S3 x N3) resulted in higher grain yields (2005, 1759, 1548 kg ha-1) and benefit-cost ratios (2.64, 2.58, and 2.58) across the same seasons. However, the differences in grain yield among the treatment combinations were statistically non-significant. These findings provide a valuable foundation for future research and agricultural practices aimed at maximizing the potential of brown top millet.
Central Bank Digital Currencies: Experimental Evidence of Deposit Conversion
Authors: Shakina Ekaterina , Hanke Michael , Ellis Scott 
Published: October 2024

Abstract
In this paper, we provide unique experimental evidence of depositors’ behaviour in presence of a possibility to convert commercial bank deposits into central bank digital currency (CBDC). Theoretically and experimentally we analyse whether such an option incentivises bank runs. We find that the availability of the deposit conversion option does not lead to a significant outflow of deposits. However, when conversion is restricted, depositors are eager to actively use it as a coordination tool. These findings highlight the importance of considering coordination and decision time in determining the choice to convert deposits into CBDC. Our study evidences that policy-makers should balance accessibility and control measures to maintain financial stability, ensuring that CBDC implementation supports the resilience of the banking system.