bluuebunny/crossref_metadata_2025_split huggingface dataset:
Health Care Cost for Children Newly Diagnosed With Inflammatory Bowel Disease
Authors: Fondell Andrew W , Mosha Maua H , Frank Cliff R , Brangi Jeffrey M , Hyams Jeffrey S 
Published: August 2019

Abstract

Background
The increasing incidence of pediatric inflammatory bowel disease (IBD), along with more extensive and severe disease in children, raises concern for related health care expenditures.

Aim
The aim of this study was to quantify and characterize costs of pediatric IBD in the year following diagnosis.

Methods
We identified all patients diagnosed with IBD at Connecticut Children’s Medical Center in 2016 with a minimum of 1 year follow-up. Clinical and demographic factors were recorded at diagnosis. We examined paid service and professional costs related to outpatient medications and infusions, outpatient procedures and radiology imaging, inpatient services, and outpatient visits. Actual dollar reimbursements were from private and public payers. Data is reported as mean ± SD and median (IQR).

Results
First-year cost data were collected on 67 patients (43 Crohn’s disease [CD], 24 ulcerative colitis [UC], mean age 13 years [SD 3.22]) revealing a mean cost of $45,753 (SD $37,938), with $43,095 (SD $30,828) for CD and $50,516 (SD $48,557) for UC. Severe CD (n = 11) had a mean cost of $71,176 (SD $43,817) and severe UC (n = 5) $134,178 (SD $40,920). Patients receiving infusion therapy had a mean cost of $59,376 (SD $38,724) compared with $27,903 (SD $28,795) for those not receiving infusions. Overall cost distribution showed 37% from infusion costs, 25% hospital costs, 18% outpatient procedures, 10% outpatient oral medications, 7% outpatient imaging, and 3% outpatient visits.

Conclusions
Infusion therapy is a key driver of first-year costs for children newly diagnosed with IBD. Understanding cost distribution in relation to disease presentation can be helpful to anticipate future related costs.
The Changing Epidemiology of Inflammatory Bowel Disease: What Goes Up May Come Down
Authors: Khalili Hamed 
Published: August 2019

Abstract
Recent epidemiologic studies have shown that although the incidence of inflammatory bowel disease (IBD) is rapidly increasing in newly industrialized countries, at the turn of the 21st century the incidence had stabilized in the Western world. In this issue of Inflammatory Bowel Diseases, Torabi and colleagues present their findings on the temporal trends and geographic variations in IBD incidence in Manitoba from 1990 to 2012 using the Manitoba Health population registry and the University of Manitoba IBD epidemiology database. Their results demonstrate an overall decrease in the incidence of IBD during the study period. They also found significant regional variations in disease incidence within Manitoba, with rates of new diagnosis of IBD remaining high in several regions. Lastly, the study found that a higher proportion of the indigenous population had a lower rate of IBD. These findings provide new insights on the changing epidemiology of IBD in the Western world. The overall declining incidence of IBD and identification of persistently low and high-risk populations in Manitoba, which traditionally has had some of the highest incidence rates of IBD, is intriguing and can provide new avenues of research for epidemiologists in the field.
Synchrony in networks of Franklin bells
Authors: Şayli Mustafa , Lai Yi Ming , Thul Rüdiger , Coombes Stephen 
Published: August 2019

Abstract
The Franklin bell is an electro-mechanical oscillator that can generate a repeating chime in the presence of an electric field. Benjamin Franklin famously used it as a lightning detector. The chime arises from the impact of a metal ball on a metal bell. Thus, a network of Franklin bells can be regarded as a network of impact oscillators. Although the number of techniques for analysing impacting systems has grown in recent years, this has typically focused on low-dimensional systems and relatively little attention has been paid to networks. Here we redress this balance with a focus on synchronous oscillatory network states. We first study a single Franklin bell, showing how to construct periodic orbits and how to determine their linear stability and bifurcation. To cope with the non-smooth nature of the impacts we use saltation operators to develop the correct Floquet theory. We further introduce a new smoothing technique that circumvents the need for saltation and that recovers the saltation operators in some appropriate limit. We then consider the dynamics of a network of Franklin bells, showing how the master stability function approach can be adapted to treat the linear stability of the synchronous state for arbitrary network topologies. We use this to determine conditions for network induced instabilities. Direct numerical simulations are shown to be in excellent agreement with theoretical results.
Follicular Helper T Cells Are Major Human Immunodeficiency Virus-2 Reservoirs and Support Productive Infection
Authors: Godinho-Santos Ana , Foxall Russell B , Antão Ana V , Tavares Bárbara , Ferreira Tiago , Serra-Caetano Ana , Matoso Paula , Sousa Ana E 
Published: August 2019

Abstract
Follicular helper T cells (Tfh), CD4 lymphocytes critical for efficient antibody responses, have been shown to be key human immunodeficiency virus (HIV)-1 reservoirs. Human immunodeficiency virus-2 infection represents a unique naturally occurring model for investigating Tfh role in HIV/acquired immune deficiency syndrome, given its slow rate of CD4 decline, low to undetectable viremia, and high neutralizing antibody titers throughout the disease course. In this study, we investigated, for the first time, Tfh susceptibility to HIV-2 infection by combining in vitro infection of tonsillar Tfh with the ex vivo study of circulating Tfh from HIV-2-infected patients. We reveal that Tfh support productive HIV-2 infection and are preferential viral targets in HIV-2-infected individuals.
Breast Cancer Screening: Beyond Mortality
Authors: Yaffe Martin J , Jong Roberta A , Pritchard Kathleen I 
Published: August 2019

AbstractTraditionally, the effectiveness of breast cancer screening has been measured in terms of reducing the number of deaths attributable to breast cancer. Other metrics such as the number of life-years or quality-adjusted life-years gained through screening may be more relevant and certainly may better reflect the important burden of the disease on younger women, their families, and society. The effects of earlier detection of breast cancer in reducing morbidities associated with treatment have often also been neglected. In addition, the harms and limitations associated with cancer screening have been poorly quantified and are seldom put into perspective vis-à-vis the benefits. Here, these alternative measures will be discussed and quantified.
Iron and Ferritin Deposition in the Ovarian Tissues of the Yellow Fever Mosquito (Diptera: Culicidae)
Authors: Geiser Dawn L , Thai Theresa N , Love Maria B , Winzerling Joy J 
Published: August 2019

Abstract
Dengue, yellow fever, and Zika are viruses transmitted by yellow fever mosquito, Aedes aegypti [Linnaeus (Diptera: Culicidae)], to thousands of people each year. Mosquitoes transmit these viruses while consuming a blood meal that is required for oogenesis. Iron, an essential nutrient from the blood meal, is required for egg development. Mosquitoes receive a high iron load in the meal; although iron can be toxic, these animals have developed mechanisms for dealing with this load. Our previous research has shown iron from the blood meal is absorbed in the gut and transported by ferritin, the main iron transport and storage protein, to the ovaries. We now report the distribution of iron and ferritin in ovarian tissues before blood feeding and 24 and 72 h post-blood meal. Ovarian iron is observed in specific locations. Timing post-blood feeding influences the location and distribution of the ferritin heavy-chain homolog, light-chain homolog 1, and light-chain homolog 2 in ovaries. Understanding iron deposition in ovarian tissues is important to the potential use of interference in iron metabolism as a vector control strategy for reducing mosquito fecundity, decreasing mosquito populations, and thereby reducing transmission rates of vector-borne diseases.
Body mass index at diagnosis is associated with survival outcome in peripheral T-cell lymphoma: a study of Chinese population
Authors: Ma Shanshan , Zhao Yanchun , Lu Danlei , Ye Xiujin , Xie Wanzhuo 
Published: August 2019

AbstractObjectiveObesity increases the risk for many diseases, including some malignancies. We found that in diffuse large B-cell lymphoma, the most common form of non-Hodgkin’s lymphoma, patients with higher body mass index had significantly longer overall survival. Patients with peripheral T-cell lymphoma usually have worse outcomes than those with diffuse large B-cell lymphoma. Nonetheless, the association between body mass index at diagnosis and survival in patients with peripheral T-cell lymphoma remains unclear.MethodsThis retrospective study included 411 peripheral T-cell lymphoma patients from January 2010 to July 2017. Patients were stratified by body mass index into low body mass index (<24.0 kg/m2) and high body mass index (≥24.0 kg/m2) groups. We mainly used Cox modelling and the Kaplan–Meier method to evaluate survival and other variables.ResultsMultivariate analysis demonstrated that body mass index, international prognostic index and triglyceride level were independent prognostic factors of overall survival. Interestingly, patients with high body mass index had significantly longer overall survival (P < 0.01), with 69% of patients alive at 3 years versus 43% in the low body mass index group. Cox analysis showed reduced mortality in the high body mass index group compared with the low body mass index group (hazard ratio = 0.511, 95% CI, 0.309–0.846, P = 0.009). In addition, patients with high body mass index and low international prognostic index had the longest overall survival (P < 0.001).ConclusionsHigh body mass index at the time of diagnosis was associated with improved overall survival in Chinese peripheral T-cell lymphoma patients.
The afterglow and kilonova of the short GRB 160821B
Authors: Troja E , Castro-Tirado A J , González J Becerra , Hu Y , Ryan G S , Cenko S B , Ricci R , Novara G , Sánchez-Rámirez R , Acosta-Pulido J A , Ackley K D , Caballero García M D , Eikenberry S S , Guziy S , Jeong S , Lien A Y , Márquez I , Pandey S B , Park I H , Sakamoto T , Tello J C , Sokolov I V , Sokolov V V , Tiengo A , Valeev A F , Zhang B B , Veilleux S 
Published: August 2019

Abstract
GRB 160821B is a short duration gamma-ray burst (GRB) detected and localized by the Neil Gehrels Swift Observatory in the outskirts of a spiral galaxy at z=0.1613, at a projected physical offset of ≈16 kpc from the galaxy’s center. We present X-ray, optical/nIR and radio observations of its counterpart and model them with two distinct components of emission: a standard afterglow, arising from the interaction of the relativistic jet with the surrounding medium, and a kilonova, powered by the radioactive decay of the sub-relativistic ejecta. Broadband modeling of the afterglow data reveals a weak reverse shock propagating backward into the jet, and a likely jet-break at ≈3.5 d. This is consistent with a structured jet seen slightly off-axis (θview ∼ θcore) while expanding into a low-density medium (n ≈ 10−3 cm−3). Analysis of the kilonova properties suggests a rapid evolution toward red colors, similar to AT2017gfo, and a low nIR luminosity, possibly due to the presence of a long-lived neutron star. The global properties of the environment, the inferred low mass (Mej ≲ 0.006 M⊙) and velocities (vej ≳ 0.05c) of lanthanide-rich ejecta are consistent with a binary neutron star merger progenitor.
Anomaly Detection in the Open Supernova Catalog
Authors: Pruzhinskaya M V , Malanchev K L , Kornilov M V , Ishida E E O , Mondon F , Volnova A A , Korolev V S 
Published: August 2019

Abstract
In the upcoming decade large astronomical surveys will discover millions of transients raising unprecedented data challenges in the process. Only the use of the machine learning algorithms can process such large data volumes. Most of the discovered transients will belong to the known classes of astronomical objects. However, it is expected that some transients will be rare or completely new events of unknown physical nature. The task of finding them can be framed as an anomaly detection problem. In this work, we perform for the first time an automated anomaly detection analysis in the photometric data of the Open Supernova Catalog (OSC), which serves as a proof of concept for the applicability of these methods to future large scale surveys. The analysis consists of the following steps: 1) data selection from the OSC and approximation of the pre-processed data with Gaussian processes, 2) dimensionality reduction, 3) searching for outliers with the use of the isolation forest algorithm, 4) expert analysis of the identified outliers. The pipeline returned 81 candidate anomalies, 27 (33%) of which were confirmed to be from astrophysically peculiar objects. Found anomalies correspond to a selected sample of 1.4% of the initial automatically identified data sample of ∼2000 objects. Among the identified outliers we recognised superluminous supernovae, non-classical Type Ia supernovae, unusual Type II supernovae, one active galactic nucleus and one binary microlensing event. We also found that 16 anomalies classified as supernovae in the literature are likely to be quasars or stars. Our proposed pipeline represents an effective strategy to guarantee we shall not overlook exciting new science hidden in the data we fought so hard to acquire. All code and products of this investigation are made publicly available‡.
Morphological evolution and galactic sizes in the L-Galaxies SA model
Authors: Irodotou Dimitrios , Thomas Peter A , Henriques Bruno M , Sargent Mark T , Hislop Jessica M 
Published: August 2019

Abstract
In this work we update the L-Galaxies semi-analytic model (SAM) to better follow the physical processes responsible for the growth of bulges via disc instabilities (leading to pseudo-bulges) and mergers (leading to classical bulges). We address the former by considering the contribution of both stellar and gaseous discs in the stability of the galaxy, and we update the latter by including dissipation of energy in gas-rich mergers. Furthermore, we introduce angular momentum losses during cooling and find that an accurate match to the observed correlation between stellar disc scale length and mass at z ∼ 0.0 requires that the gas loses 20% of its initial specific angular momentum to the corresponding dark matter halo during the formation of the cold gas disc. We reproduce the observed trends between the stellar mass and specific angular momentum for both disc- and bulge-dominated galaxies, with the former rotating faster than the latter of the same mass. We conclude that a two-component instability recipe provides a morphologically diverse galaxy sample which matches the observed fractional breakdown of galaxies into different morphological types. This recipe also enables us to obtain an excellent fit to the morphology-mass relation and stellar mass function of different galactic types. Finally, we find that energy dissipation during mergers reduces the merger remnant sizes and allows us to match the observed mass-size relation for bulge-dominated systems.
Investigation of Stark line broadening within spectral series of potassium and copper isoelectronic sequences
Authors: Dojčinović Ivan P , Trklja Nora , Tapalaga Irinel , Purić Jagoš 
Published: August 2019

Abstract
We have investigated Stark line broadening within the spectral series of potassium-like and copper-like emitters, both separately and together. The analysis was performed for fixed values of electronic density Ne = 1022 m−3 and temperature $T = 100\, 000$ K. Algorithms made for fast data processing also serve for temperature and density normalization of data. Relations obtained using the regularity-based analysis enable predictions of Stark widths for transitions that have not yet been calculated or measured. Results of present investigation can be used for quality control of available Stark width data.
CBTRUS Statistical Report: Primary Brain and Other Central Nervous System Tumors Diagnosed in the United States in 2012–2016
Authors: Ostrom Quinn T , Cioffi Gino , Gittleman Haley , Patil Nirav , Waite Kristin , Kruchko Carol , Barnholtz-Sloan Jill S 
Published: August 2019

AbstractThe Central Brain Tumor Registry of the United States (CBTRUS), in collaboration with the Centers for Disease Control and Prevention and National Cancer Institute, is the largest population-based registry focused exclusively on primary brain and other central nervous system (CNS) tumors in the United States (US) and represents the entire US population. This report contains the most up-to-date population-based data on primary brain tumors available and supersedes all previous reports in terms of completeness and accuracy. All rates are age-adjusted using the 2000 US standard population and presented per 100,000 population. The average annual age-adjusted incidence rate (AAAIR) of all malignant and non-malignant brain and other CNS tumors was 23.41 (Malignant AAAIR = 7.08, non-Malignant AAAIR = 16.33). This rate was higher in females compared to males (25.84 versus 20.82), Whites compared to Blacks (23.50 versus 23.34), and non-Hispanics compared to Hispanics (23.84 versus 21.28). The most commonly occurring malignant brain and other CNS tumor was glioblastoma (14.6% of all tumors), and the most common non-malignant tumor was meningioma (37.6% of all tumors). Glioblastoma was more common in males, and meningioma was more common in females. In children and adolescents (age 0–19 years), the incidence rate of all primary brain and other CNS tumors was 6.06. An estimated 86,010 new cases of malignant and non-malignant brain and other CNS tumors are expected to be diagnosed in the US in 2019 (25,510 malignant and 60,490 non-malignant). There were 79,718 deaths attributed to malignant brain and other CNS tumors between 2012 and 2016. This represents an average annual mortality rate of 4.42. The five-year relative survival rate following diagnosis of a malignant brain and other CNS tumor was 35.8%, and the five-year relative survival rate following diagnosis of a non-malignant brain and other CNS tumors was 91.5%.
Thermal-siphon phenomenon and thermal/electric conduction in complex networks
Authors: Xiong Kezhao , Liu Zonghua , Zeng Chunhua , Li Baowen 
Published: August 2019

Abstract
In past decades, a lot of studies have been carried out on complex networks and heat conduction in regular lattices. However, very little attention has been paid to the heat conduction in complex networks. In this work, we study (both thermal and electric) energy transport in physical networks rewired from 2D regular lattices. It is found that the network can be transferred from a good conductor to a poor conductor, depending on the rewired network structure and coupling scheme. Two interesting phenomena were discovered: (i) the thermal-siphon effect—namely the heat flux can go from a low-temperature node to a higher-temperature node and (ii) there exits an optimal network structure that displays small thermal conductance and large electrical conductance. These discoveries reveal that network-structured materials have great potential in applications in thermal-energy management and thermal-electric-energy conversion.
The role of networks in antitrust investigations
Authors: Elliott Matthew , Galeotti Andrea 
Published: August 2019

Abstract
Antitrust investigations typically focus on the competitive pressures coming from within the defined markets of interest. However, competitive pressures can also come from other markets. Even when individually these markets place only weak constraints on one another, collectively they may matter. A networks approach to modelling competition permits a systemic view of competition that can sometimes paint a more accurate picture. We demonstrate this through some simple examples, and show more generally how tools from the networks literature can be applied to capture competition across a system of interrelated markets. As a leading example, we consider antitrust investigations into supermarkets where local geographic markets have been used as the basis of investigation.
Comparative Transcriptomics Analysis of Brassica napus L. during Seed Maturation Reveals Dynamic Changes in Gene Expression between Embryos and Seed Coats and Distinct Expression Profiles of Acyl-CoA-Binding Proteins for Lipid Accumulation
Authors: Liao Pan , Woodfield Helen K , Harwood John L , Chye Mee-Len , Scofield Simon 
Published: August 2019

Abstract
Production of vegetable oils is a vital agricultural resource and oilseed rape (Brassica napus) is the third most important oil crop globally. Although the regulation of lipid biosynthesis in oilseeds is still not fully defined, the acyl-CoA-binding proteins (ACBPs) have been reported to be involved in such metabolism, including oil accumulation, in several plant species. In this study, progressive changes in gene expression in embryos and seed coats at different stages of seed development were comprehensively investigated by transcriptomic analyses in B. napus, revealing dynamic changes in the expression of genes involved in lipid biosynthesis. We show that genes encoding BnACBP proteins show distinct changes in expression at different developmental stages of seed development and show markedly different expression between embryos and seed coats. Both isoforms of the ankyrin-repeat BnACBP2 increased during the oil accumulation period of embryo development. By contrast, the expression of the three most abundant isoforms of the small molecular mass BnACBP6 in embryos showed progressive reduction, despite having the highest overall expression level. In seed coats, BnACBP3, BnACBP4 and BnACBP5 expression remained constant during development, whereas the two major isoforms of BnACBP6 increased, contrasting with the data from embryos. We conclude that genes related to fatty acid and triacylglycerol biosynthesis showing dynamic expression changes may regulate the lipid distribution in embryos and seed coats of B. napus and that BnACBP2 and BnACBP6 are potentially important for oil accumulation.
Urban Uprisings: The Troubled Relationship Between Citizens and Police in France, the UK, and the USA
Authors: Slooter Luuk 
Published: August 2019

AbstractViolent outbursts in Paris (2005), London (2011), and Ferguson (2014) illustrate the problematic and disturbing relationship between citizens and police in the ‘West’. While these episodes are often portrayed as ‘apolitical’ and ‘criminal’ in media and political debates, they are in the academic literature predominantly seen as (unarticulated) forms of political protests against structural inequalities. Building on this political perspective, I will first argue that the interplay between structural, police, and ‘private’ violence is at the core of these urban uprisings. Subsequently, I will identify four common factors that contributed to the onset and legitimization of collective violence in Paris, London, and Ferguson: an emotive and symbolically significant incident, often with a young inhabitant of a marginalized neighbourhood as protagonist; police involvement; unclarity and pre-violence rumours; and pre-existing us-them divides. In the conclusion, I will emphasize the importance and need of a systemic approach towards police reform.