bluuebunny/crossref_metadata_2025_split huggingface dataset:
ERK1/2 and p38 regulate inter-individual variability in ozone-mediated IL-8 gene expression in primary human bronchial epithelial cells
Authors: Bowers Emma C. , McCullough Shaun D. , Morgan David S. , Dailey Lisa A. , Diaz-Sanchez David 
Published: June 2018

AbstractInter-individual variability is observed in all biological responses; however this variability is difficult to model and its underlying mechanisms are often poorly understood. This issue currently impedes understanding the health effects of the air pollutant ozone. Ozone produces pulmonary inflammation that is highly variable between individuals; but reproducible within a single individual, indicating undefined susceptibility factors. Studying inter-individual variability is difficult with common experimental models, thus we used primary human bronchial epithelial cells (phBECs) collected from many different donors. These cells were cultured, exposed to ozone, and the gene expression of the pro-inflammatory cytokine IL-8 was measured. Similar to in vivo observations, we found that ozone-mediated IL-8 expression was variable between donors, but reproducible within a given donor. Recent evidence suggests that the MAP kinases ERK1/2 and p38 mediate ozone-induced IL-8 transcription, thus we hypothesized that differences in their activation may control IL-8 inter-individual variability. We observed a significant correlation between ERK1/2 phosphorylation and IL-8 expression, suggesting that ERK1/2 modulates the ozone-mediated IL-8 response; however, we found that simultaneous inhibition of both kinases was required to achieve the greatest IL-8 inhibition. We proposed a “dimmer switch” model to explain how the coordinate activity of these kinases regulate differential IL-8 induction.
A Biomechanical Comparison of Single-Leg Landing and Unplanned Sidestepping
Authors: Chinnasee Chamnan , Weir Gillian , Sasimontonkul Siriporn , Alderson Jacqueline , Donnelly Cyril 
Published: June 2018

AbstractUnplanned sidestepping and single-leg landing have both been used to screen athletes for injury risk in sport. The aim of this study was to directly compare the lower limb mechanics of three single-leg landing tasks and an unplanned sidestepping task. Thirteen elite female team sport athletes completed a series of non-contact single-leg drop landings, single-leg countermovement jumps, single-leg jump landings and unplanned sidestepping in a randomized counterbalanced design. Three dimensional kinematics (250 Hz) and ground reaction force (2,000 Hz) data with a participant specific lower limb skeletal model were used to calculate and compare hip, knee and ankle joint kinematics, peak joint moments, instantaneous joint power and joint work during the weight acceptance phase of each sporting task (α=0.05). Peak knee joint moments and relevant injury risk thresholds were used to classify each athlete's anterior cruciate ligament injury risk during unplanned sidestepping and single-leg jump landing. Results showed that peak joint moments, power and work were greater during the single-leg jump landing task when compared to the single-leg drop landings and single-leg countermovement jumps tasks. Peak frontal and sagittal plane knee joint moments, knee joint power, as well as hip and knee joint work were greater during unplanned sidestepping when compared to the landing tasks. Peak ankle joint moments, power and work were greater during the landing tasks when compared to unplanned sidestepping. For 4 of the 13 athletes tested, their anterior cruciate ligament injury risk classification changed depending on whether they performed an unplanned sidestepping or single-leg jump landing testing procedure. To summarize, a single-leg jump landing testing procedure places a larger mechanical on the ankle joint when compared to single-leg drop landings, single-leg countermovement jumps and unplanned sidestepping. An unplanned sidestepping testing procedure places a larger mechanical demand on the knee joint when compared to single-leg landing tasks. Both unplanned sidestepping and single-leg jump landing testing procedures are recommended for classifying an athlete's anterior cruciate ligament injury risk in sport.
Kleinzelliges Lungenkarzinom
Authors: Reinmuth Niels , Hoffmann Hans 
Published: June 2018

ZusammenfassungDas kleinzellige Lungenkarzinom stellt eine besonders aggressive Tumorentität dar und ist durch schnellen Progress, sehr frühe Metastasierung und schlechte Prognose charakterisiert. Nur wenige Patienten werden in einem frühen Erkrankungsstadium diagnostiziert, bei dem in ausgewählten Fällen eine chirurgische Resektion diskutiert werden kann. Chemotherapie und Strahlentherapie sind initial häufig effektiv. Allerdings erleiden die meisten Patienten im metastasierten Stadium nach zunächst gutem Ansprechen auf eine platinhaltige Chemotherapie einen Progress mit dann nur limitierten Therapieoptionen.
Are Corpses the Best Method for Practical Anatomy Assessment, According to Health Course Students?
Authors: Soares B. , Ribeiro F. , Santos I. , Silva A. , Amorim M. , Shiosaki R. , Bettencourt Pires M. , Schwingel P. , Silva Júnior E. 
Published: June 2018

AbstractThe aim of this study was to evaluate the student's conception in reference to the teaching materials used for the practical assessment of the discipline of Human Anatomy. The study was quantitative and qualitative, exploratory and descriptive. The materials were industrialized synthetic anatomical models, models made of inexpensive material by students, human cadaveric material, photocopied images and software. The study included 97 students, who after analysis indicated cadaveric materials (35%) as the best educational tool to be applied for the practical assessments of Anatomy. The photocopied images (3%) were the material with which the students presented greater difficulty. The content analysis of the discursive questions showed 5 factors in learning Human Anatomy: little time per table; difficulty in identifying, locating and memorization of anatomical structures; the quality of material used; comparing these materials; and cadaveric material. The study proved to be relevant for the evolution of teaching quality, in addition to the cadaveric material as the best tool to be used in practical assessments of Human Anatomy. We suggest the use of this material the more frequent, in laboratories that have the same materials as analyzed here, because the corpse can never be substituted in teaching and learning of Anatomy.
2.8 Reduction of Azides
Authors: Monguchi Y. , Sajiki H. 
Published: June 2018

AbstractThis chapter covers recent progress in the catalytic hydrogenation and catalytic transfer hydrogenation of azides, including continuous-flow hydrogenation using heterogeneous catalysts, hydrogenative formylation, and hydrogenative alkylation for natural product synthesis. Recently developed catalysts for the chemoselective reduction of azides in the presence of other coexisting reducible functionalities are especially highlighted. Furthermore, a method for the selective semihydrogenation of alkynes to the corresponding alkenes leaving coexisting azides intact is also presented.
NMDA Receptor-Mediated Motor Cortex Plasticity After 20 Hz Transcranial Alternating Current Stimulation
Authors: Wischnewski M , Engelhardt M , Salehinejad M A , Schutter D J L G , Kuo M -F , Nitsche M A 
Published: June 2018

Abstract
Transcranial alternating current stimulation (tACS) has been shown to modulate neural oscillations and excitability levels in the primary motor cortex (M1). These effects can last for more than an hour and an involvement of N-methyl-d-aspartate receptor (NMDAR) mediated synaptic plasticity has been suggested. However, to date the cortical mechanisms underlying tACS after-effects have not been explored. Here, we applied 20 Hz beta tACS to M1 while participants received either the NMDAR antagonist dextromethorphan or a placebo and the effects on cortical beta oscillations and excitability were explored. When a placebo medication was administered, beta tACS was found to increase cortical excitability and beta oscillations for at least 60 min, whereas when dextromethorphan was administered, these effects were completely abolished. These results provide the first direct evidence that tACS can induce NMDAR-mediated plasticity in the motor cortex, which contributes to our understanding of tACS-induced influences on human motor cortex physiology.
Relationships between ultimate pH and antioxidant enzyme activities and gene expression in pork loins
Authors: Wang Jin , Zeng Qi‐fan , Wang Hui , Chen Wei , Zeng Yong‐qing 
Published: June 2018

AbstractUltimate pH (pHu) is a major determinant factor of meat quality. In this study, we investigated the effects of pHu on the muscle antioxidant capacity, and the relationship between pHu and muscle antioxidant capacity of pigs. A total of 137 pigs from three pig breeds with the same feeding condition were slaughtered and used to measure the pHu, superoxide dismutase (SOD), glutathione peroxidase (GSH‐PX), total antioxidant capacity (T‐AOC), and malondialdehyde (MDA) content, and gene expression of SOD1 and GPX4. Loins from 137 pigs of three breeds were classified based on pHu into three groups: low (L‐pH: ≤5.50), intermediate (I‐pH: 5.51‐5.90), and high (H‐pH: ≥5.91). A majority of loins (47.5%–52%) were classified into the intermediate group. The results suggested that the pHu value was correlated with the activity of SOD, GSH‐PX, T‐AOC, and MDA, and gene expression of SOD1 and GPX4 in all pigs. In addition, our results also indicated a linear relationship between the pHu value and antioxidant traits. The pHu value accounted for 23%–40% of the variation in the antioxidant traits. These results suggested that increased pHu reduce the lipid peroxidation, and also indicated that pHu may be a key factor explaining the variation in the activity of antioxidant enzymes and gene expression in pork loins.
The association between periodontal disease severity and metabolic syndrome in Vietnamese patients
Authors: Pham TAV 
Published: June 2018

AbstractObjectiveTo investigate the association between periodontal disease severity and metabolic syndrome (MetS) in a group of Vietnamese patients.MethodsA total of 412 participants (114 males, 298 females, average age 57.8 ± 5.7 years) including 206 patients with MetS and 206 participants without MetS were selected for this study. Information on sociodemographic characteristics, dental behaviours and smoking status was collected from a self‐administrated questionnaire. Periodontal status including plaque index (PI), gingival index (GI) pocket depth (PD) and clinical attachment level (CAL) was recorded. Logistic regression analyses were used to evaluate the association between severity of periodontal disease and MetS with adjustments for related confounders.ResultsThe prevalence of moderate and severe periodontitis assessed by GI, PD and CAL was all significantly higher in the MetS group than in the control group and was significantly increased by a number of MetS components. Logistic regression, adjusted for confounders, showed that people with mean PI ≥2.51 or GI ≥1.01 or number of teeth with bleeding on probing of ≥20 teeth or PD ≥3.66 or CAL ≥3.66 showed a significant association with greater OR for MetS compared to counterparts (P < .05). The OR for MetS was 4.06 (95% CI 2.11‐7.84) in severe periodontitis patients compared to non‐periodontitis participants (P < .001).ConclusionMuch severe and extensive periodontal disease was found in MetS participants and increased with number of MetS components. Participants with higher periodontal parameters had a higher risk of MetS.
Relationship of objective street quality attributes with youth physical activity: findings from the Healthy Communities Study
Authors: Kaczynski A. T. , Besenyi G. M. , Child S. , Morgan Hughey S. , Colabianchi N. , McIver K. L. , Dowda M. , Pate R. R. ,   on behalf of the Healthy Communities Study Team
Published: June 2018

SummaryBackgroundResidential environments may significantly influence youth physical activity (PA). However, few studies have examined detailed street quality attributes via observational audits in relation to context‐specific PA among youth.ObjectivesThe objective of this study was to explore whether the overall quality of street environments, as well as specific attributes, was associated with neighbourhood‐based and street‐based PA within a national sample of youth in the Healthy Communities Study.MethodsData were collected from 4616 youth from 130 communities across the USA. Youth PA in the neighbourhood and on the participant's street was captured using 7‐d recall interviews. Windshield survey observational audits documented five street quality variables: burned, boarded up or abandoned residential units, litter, overall condition of residences, street type and presence of sidewalks in good condition.ResultsYouth with no litter on their street reported significantly lower neighbourhood‐based PA and youth living on a side street, cul‐de‐sac, dead‐end or one‐way street reported greater neighbourhood‐based PA. No significant associations were detected for the overall street quality index or with street‐based PA.ConclusionsSpecific street quality attributes may be associated with youth PA. Further research and collaboration between diverse disciplines and agencies should focus on understanding and improving street quality to promote youth PA and health.
Mechanize or exit farming? Multiple‐treatment‐effects model and external validity of adoption impacts of mechanization among Nepalese smallholders
Authors: Takeshima Hiroyuki 
Published: June 2018

AbstractThe future of smallholders in developing countries is becoming increasingly uncertain in the face of rising farm wages. The custom‐hiring of tractors, in which tractor owners provide non‐owner farmers with land preparation and transport services for fees, has spread among smallholders in Asia, including Nepal. However, estimating the adoption impacts of agricultural mechanization by smallholders is complex as we must also take into account smallholders’ options to exit farming. We investigate this issue by applying multinomial logit inverse‐probability weighting and sample selection panel data methods to data on smallholders in lowland Nepal. Our results are generally consistent with the hypothesis that smallholders who are likely to benefit more from adopting tractors are also more likely to exit farming. Where smallholders are less likely to exit farming, the use of tractors through custom‐hiring may help smallholders on average to earn greater total and agricultural incomes. However, where they are more likely to exit farming, the ability of custom‐hired tractors to sustain smallholder farming systems may become weaker. The results also offer insights into how the external validity of technology adoption impact evaluation may be affected in some settings.
Understanding the interplay between bus, metro, and cab ridership dynamics in Shenzhen, China
Authors: Yue Mengxue , Kang Chaogui , Andris Clio , Qin Kun , Liu Yu , Meng Qingxiang 
Published: June 2018

AbstractThe most common mass transit modes in metropolitan cities include buses, subways, and taxicabs, each of which contribute to an interconnected complex network that delivers urban dwellers to their destinations. Understanding the intertwined usages of these three transit modes at different places and time allows for better sensing of urban mobility and the built environment. In this article, we leverage a comprehensive data collection of bus, metro, and taxicab ridership from Shenzhen, China to unveil the spatio‐temporal interplay between different mass transit modes. To achieve this goal, we develop a novel spectral clustering framework that imposes spatio‐temporal similarities between mass transit mode usage in urban space and differentiates urban spaces associated with distinct ridership patterns of mass transit modes. Five resulting categories of urban spaces are identified and interpreted with auxiliary knowledge of the city's metro network and land‐use functionality. In general, different categorized urban spaces are associated with different accessibility levels (such as high‐, medium‐, and low‐ranked) and different urban functionalities (such as residential, commercial, leisure‐dominant, and home–work balanced). The results indicate that different mass transit modes cooperate or compete based on demographic and socioeconomic attributes of the underlying urban environments. Our proposed analytical framework provides a novel and effective way to explore the mass transit system and the functional heterogeneity in cities. It demonstrates great potential for assisting policymakers and municipal managers in optimizing public transportation facility allocation and city‐wide daily commuting distribution.
Rapid Influence of Word‐Talker Associations on Lexical Access
Authors: Kim Jonny , Drager Katie 
Published: June 2018

AbstractPrevious work on English and Korean demonstrates that words are more quickly identified as real words when they are produced by a voice congruent with the age of the talkers who are most likely to use the word (Kim, 2016, Laboratory Phonology, 7, 18; Walker & Hay, 2011, Laboratory Phonology, 2, 219–237). However, this previous work presents stimuli blocked by voice, giving the participant ample time to form expectations about the talker and the words that the talker would likely use. To test whether the effect can be observed in the absence of cues to talker age prior to word onset, the current experiment replicates Kim (2016, Laboratory Phonology, 7, 18) but without blocking by talker. Results from the current experiment confirm earlier findings and they demonstrate that the effect can be observed even without the listener having any expectations about the talker prior to hearing the word. We discuss the implications of these results for models of speech perception, suggesting that lexical access is rapidly boosted by socio‐indexical phonetic cues that are congruent with socio‐indexical lexical information.
Visual attention on a respiratory function monitor during simulated neonatal resuscitation: an eye-tracking study
Authors: Katz Trixie A , Weinberg Danielle D , Fishman Claire E , Nadkarni Vinay , Tremoulet Patrice , te Pas Arjan B , Sarcevic Aleksandra , Foglia Elizabeth E 
Published: June 2018

ObjectiveA respiratory function monitor (RFM) may improve positive pressure ventilation (PPV) technique, but many providers do not use RFM data appropriately during delivery room resuscitation. We sought to use eye-tracking technology to identify RFM parameters that neonatal providers view most commonly during simulated PPV.DesignMixed methods study. Neonatal providers performed RFM-guided PPV on a neonatal manikin while wearing eye-tracking glasses to quantify visual attention on displayed RFM parameters (ie, exhaled tidal volume, flow, leak). Participants subsequently provided qualitative feedback on the eye-tracking glasses.SettingLevel 3 academic neonatal intensive care unit.ParticipantsTwenty neonatal resuscitation providers.Main outcome measuresVisual attention: overall gaze sample percentage; total gaze duration, visit count and average visit duration for each displayed RFM parameter. Qualitative feedback: willingness to wear eye-tracking glasses during clinical resuscitation.ResultsTwenty providers participated in this study. The mean gaze sample captured wa s 93% (SD 4%). Exhaled tidal volume waveform was the RFM parameter with the highest total gaze duration (median 23%, IQR 13–51%), highest visit count (median 5.17 per 10 s, IQR 2.82–6.16) and longest visit duration (median 0.48 s, IQR 0.38–0.81 s). All participants were willing to wear the glasses during clinical resuscitation.ConclusionWearable eye-tracking technology is feasible to identify gaze fixation on the RFM display and is well accepted by providers. Neonatal providers look at exhaled tidal volume more than any other RFM parameter. Future applications of eye-tracking technology include use during clinical resuscitation.
How good are GPs at adhering to a pragmatic trial protocol in primary care? Results from the ADDITION-Cambridge cluster-randomised pragmatic trial
Authors: Laxy Michael , Wilson Edward C F , Boothby Clare E , Griffin Simon J 
Published: June 2018

ObjectiveTo assess the fidelity of general practitioners’ (GPs) adherence to a long-term pragmatic trial protocol.DesignRetrospective analyses of electronic primary care records of participants in the pragmatic cluster-randomised ADDITION (Anglo-Danish-Dutch Study of Intensive Treatment In People with Screen Detected Diabetes in Primary Care)-Cambridge trial, comparing intensive multifactorial treatment (IT) versus routine care (RC). Data were collected from the date of diagnosis until December 2010.SettingPrimary care surgeries in the East of England.Study sample/participantsA subsample (n=189, RC arm: n=99, IT arm: n=90) of patients from the ADDITION-Cambridge cohort (867 patients), consisting of patients 40–69 years old with screen-detected diabetes mellitus.InterventionsIn the RC arm treatment was delivered according to concurrent treatment guidelines. Surgeries in the IT arm received funding for additional contacts between GPs/nurses and patients, and GPs were advised to follow more intensive treatment algorithms for the management of glucose, lipids and blood pressure and aspirin therapy than in the RC arm.Outcome measuresThe number of annual contacts between patients and GPs/nurses, the proportion of patients receiving prescriptions for cardiometabolic medication in years 1–5 after diabetes diagnosis and the adherence to prescription algorithms.ResultsThe difference in the number of annual GP contacts (β=0.65) and nurse contacts (β=−0.15) between the study arms was small and insignificant. Patients in the IT arm were more likely to receive glucose-lowering (OR=3.27), ACE-inhibiting (OR=2.03) and lipid-lowering drugs (OR=2.42, all p values <0.01) than patients in the RC arm. The prescription adherence varied between medication classes, but improved in both trial arms over the 5-year follow-up.ConclusionsThe adherence of GPs to different aspects of the trial protocol was mixed. Background changes in healthcare policy need to be considered as they have the potential to dilute differences in treatment intensity and hence incremental effects.Trial registration numberISRCTN86769081.