bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinicopathological features and endoscopic characteristics of inverted sessile serrated adenomas/polyps
Authors: Takashima Kenji , Oono Yasuhiro , Kojima Motohiro , Ikematsu Hiroaki , Akimoto Tetsuo , Yano Tomonori 
Published: February 2019

Abstract
Background and study aims This study was designed to clarify clinicopathological, endoscopic, and genetic characteristics of inverted sessile serrated adenomas/polyps.
Patients and methods In this retrospective study, we reviewed the pathology reports of patients treated in our hospital between January 2010 and June 2015 and identified sessile serrated adenomas/polyps that were diagnosed with endoscopic resected specimens. Clinicopathological, endoscopic, and genetic features were compared between the inverted and ordinary types.
Results Among the 104 sessile serrated adenomas/polyps, 37 lesions were inverted (35.6 %). The inverted types had two patterns of invasion: expansive and infiltrating growth. Expansive growth was observed in 15 cases (40.5 %) and infiltrating in 22 (59.5 %). Regarding the clinicopathological findings and endoscopic characteristics of the inverted types, presence of adherent mucous, location in the right-side colon, an expanded type-II pit pattern, irregularly dilated vessels, and a depression were demonstrated in 89 % (33/37), 73 % (27/37), 54 % (20/37), 75 % (28/37), and 35 % (13/37), respectively. Contrastingly, these were demonstrated in 86 % (58/67), 84 % (56/67), 55 % (37/67), 58 % (39/67), and 0 % (0/67), respectively, in the ordinary type. In the univariate analysis, male sex and a depression in the adenoma/polyp were significantly associated with inverted types (P < 0.001). BRAF mutation at codon 600 was found in six of seven ordinary types and in 11 of 11 of the inverted types. KRAS, NRAS, and PIK3CA mutations were not found in the ordinary and inverted types.
Conclusion More than 30 % of sessile serrated adenomas/polyps were pathologically diagnosed as inverted, and approximately 40 % of them were of the expansive growth type and easily diagnosed with endoscopy.
EUS-guided coil placement for acute gastric variceal bleeding induced by non-EUS-guided variceal glue injection (with video)
Authors: Mazzawi Tarek , Markhus Carl , Havre Roald , Do-Cong Pham Khanh 
Published: February 2019

Abstract
Background and study aims Endoscopic ultrasound (EUS)-guided coil placement is a new emerging technique for management of gastric varices. In this video case report, we describe an EUS-guided coil placement for managing acute bleeding of gastric varices, following an unsuccessful glue injection to achieve hemostasis.
Lithopedion Causing Intestinal Obstruction in a 71-Year-Old Woman: A Case Report
Authors: de Oliveira Francisco Eliomar Gomes , Santos Sandra Regina Alves dos , Duarte Bruno Gomes , Sisnando Alexandre Sabino 
Published: February 2019

AbstractEctopic pregnancy is the leading cause of pregnancy-related death during the first trimester, and it occurs in 1 to 2% of pregnancies. Over 90% of ectopic pregnancies are located in the fallopian tube. Abdominal pregnancy refers to an ectopic pregnancy that has implanted in the peritoneal cavity, external to the uterine cavity and fallopian tubes. The estimated incidence is 1 per 10,000 births and 1.4% of ectopic pregnancies. Lithopedion is a rare type of ectopic pregnancy, and it occurs when the fetus from an unrecognized abdominal pregnancy may die and calcify. The resulting “stone baby” may not be detected for decades and may cause a variety of complications. Lithopedion is a very rare event that occurs in 0.0054% of all gestations. About 1.5 to 1.8% of the abdominal babies develop into lithopedion. There are only ∼ 330 known cases of lithopedion in the world. We describe a lithopedion that complicated as intestinal obstruction in a 71-year-old woman.
Patient Satisfaction and Quality of Life with Enhanced Recovery Protocols
Authors: Li Debbie , Jensen Christine 
Published: February 2019

AbstractWhile studies have demonstrated the benefits of Enhanced Recovery after Surgery (ERAS) programs in reducing length of stay and costs without increasing complications, fewer studies have evaluated patient satisfaction and quality of life (QOL) with enhanced recovery protocols. The aim of this project was to summarize the literature comparing satisfaction and quality of life after colorectal surgery following treatment within an ERAS protocol to standard postoperative care. The available evidence suggests patients suffer no detriment to satisfaction or quality of life with use of ERAS protocols, and may suffer less fatigue and return to activities sooner. Most publications reported no adverse effects on postoperative pain. However, a limited number of studies suggest patients may experience increased early postoperative pain with ERAS pathways, particularly following open colorectal procedures. Future research should focus on potential improvements in ERAS protocols to better manage postoperative pain. Overall, the evidence supports more widespread implementation of ERAS pathways in colorectal surgery.
Reduction and Association of the Lunotriquetral Ligament for Reverse Perilunate Dislocation
Authors: Huang Hui-Kuang , Tsai Tung-Yeh , Wang Jung-Pan 
Published: February 2019

Abstract
Background Reverse perilunate injuries are rare. Contrary to perilunate injuries, the violent force would start from the lunotriquetral ligament, go reversely toward the radial side, and cause the reverse or ulnar-sided perilunate dislocation.
Case Description We describe a 31-year-old man with a reverse perilunate dislocation, who presented to our institution 3 weeks after a motorcycle accident. The patient was successfully treated with the reduction and association of the lunate and triquetrum (RALT) procedure by using closed maneuver and percutaneous headless compression screw fixation. The patient can obtain a good radiographic result and satisfactory function at the 30-month follow-up.
Literature Review Many case series were reported concerning the perilunate injuries. However, few cases of reverse perilunate dislocation have been reported in the literature. No cases of reverse perilunate dislocation treated 3 weeks after the injury with the RALT procedure have been reported.
Clinical Relevance In this case, we found that the dislocation could still be reduced with the closed maneuver. With the RALT procedure, the carpal alignment can be maintained and the stability can be regained. Also, the functional outcomes are good.
Developing a Core Outcome Set for Cesarean Delivery Maternal Infectious Morbidity Outcomes
Authors: Briscoe Kristin E. , Haas David M. 
Published: February 2019

Objective This study aimed to develop a core outcome set of primary outcomes for studies involving cesarean deliveries with infectious morbidity outcomes.
Study Design Authors reported primary outcomes from 11 Cochrane systematic reviews (SRs), 12 other SRs, and 327 randomized controlled trials (RCTs). These outcomes were condensed into 20 primary outcome groups. Next, a modified Delphi technique was used to gain consensus on key outcomes. Authors from included SRs were sent a questionnaire consisting of a free response and multiple-choice questions. These data were used to propose a set of core outcomes.
Results The most frequent outcomes in RCTs were composite “infectious outcomes” (24%) with the second most common being endometritis (12%). The most common reported SR outcomes were wound infection (21%) and endometritis (16%). For the Delphi survey free response portion, wound infection (88%) and endometritis (79%) were the most commonly endorsed outcomes. Chosen list outcomes were maternal mortality (83%), wound infection (83%), wound complications (86%), and postpartum endometritis (80%). The proposed final core outcome set for cesarean trials was endometritis (primary outcome), maternal mortality, wound infection, wound complications, febrile morbidity, and neonatal morbidity.
Conclusion Utilizing defined core outcomes in all studies of cesarean section can harmonize trial reports and allow data synthesis for meta-analyses.
Enhancing joint reconstruction and segmentation with non-convex Bregman iteration
Authors: Corona Veronica , Benning Martin , Ehrhardt Matthias J , Gladden Lynn F , Mair Richard , Reci Andi , Sederman Andrew J , Reichelt Stefanie , Schönlieb Carola-Bibiane 
Published: February 2019

Abstract
All imaging modalities such as computed tomography, emission tomography and magnetic resonance imaging require a reconstruction approach to produce an image. A common image processing task for applications that utilise those modalities is image segmentation, typically performed posterior to the reconstruction. Recently, the idea of tackling both problems jointly has been proposed. We explore a new approach that combines reconstruction and segmentation in a unified framework. We derive a variational model that consists of a total variation regularised reconstruction from undersampled measurements and a Chan–Vese-based segmentation. We extend the variational regularisation scheme to a Bregman iteration framework to improve the reconstruction and therefore the segmentation. We develop a novel alternating minimisation scheme that solves the non-convex optimisation problem with provable convergence guarantees. Our results for synthetic and real data show that both reconstruction and segmentation are improved compared to the classical sequential approach.
Are Many Patients Diagnosed With Healthcare-associated Clostridioides difficile Infections Colonized With the Infecting Strain on Admission?
Authors: Gonzalez-Orta Melany , Saldana Carlos , Ng-Wong Yilen , Cadnum Jennifer , Jencson Annette , Jinadatha Chetan , Donskey Curtis J 
Published: February 2019

Abstract
In a cohort of 480 patients admitted to an acute care hospital, 68 (14%) had positive perirectal cultures for toxigenic Clostridioides difficile on admission. Of the 11 patients (2%) diagnosed with healthcare-associated C. difficile infections, 3 (27%) had genetically related admission and infection isolates, based on whole-genome sequencing.
Stand-level windthrow patterns and long-term dynamics of surviving trees in natural secondary stands after a stand-replacing windthrow event
Authors: Shibuya Masato , Ishibashi Satoshi 
Published: February 2019

Abstract
We examined typhoon windthrow patterns in stand-scale permanent plots within three natural forests and the long-term dynamics of surviving trees in two of these plots. The aim was to verify whether pre-disturbance composition and structure affected windthrow damage and stand recovery. The stands, which were in Hokkaido, the northernmost main island of Japan, differed in pre-disturbance composition (coniferous, mixed and broadleaved stands) and structure, and the basal area losses by the windthrow event were 81–93 per cent. Tree mortality was significantly related to tree size (diameter at breast height) and species. The windthrow patterns differed among the three stands; and, windthrow severity was affected by the pre-disturbance composition and structure. The mortality of trees that survived the windthrow event was ~60 per cent in the two plots. The surviving trees comprised a majority of the canopy layer in the secondary stands. The relative basal area of surviving trees decreased rapidly with increasing tree density in the stand initiation stage but differed between plots. Consequently, the pre-disturbance composition and structure influenced windthrow severity, stand recovery and secondary succession in the recovered stands.
Evidence of Bidirectional Associations Between Depressive Symptoms and Body Mass Among Older Adults
Authors: Emery Charles F , Finkel Deborah , Gatz Margaret , Dahl Aslan Anna K 
Published: February 2019

Abstract

Objectives
Body fat, measured with body mass index (BMI), and obesity are associated with depressive symptoms. Among younger adults there is stronger evidence of obesity leading to depressive symptoms than of depressive symptoms leading to obesity, but the temporal relationship is unknown among older adults. This study utilized dual-change-score models (DCSMs) to determine the directional relationship between body mass and depressive symptoms among older adults.

Method
Participants (n = 1,743) from the Swedish Twin Registry (baseline age range 50–96 years) completed at least one assessment of BMI (nurse measurement of height and weight) and the Center for Epidemiologic Studies-Depression scale (CESD). More than half the sample completed 3 or more assessments, scheduled at intervals of 2–4 years. DCSMs modeled the relationship of BMI and CESD across age, both independently and as part of bivariate relationships.

Results
Depressive symptoms contributed to subsequent changes in BMI after age 70, while BMI contributed to subsequent changes in depressive symptoms after age 82. Thus, there is a reciprocal relationship that may change with age. The effect was more pronounced for women.

Discussion
The association of BMI and depressive symptoms is bidirectional among older adults, and it appears to be affected by both age and sex.
Generating approximate halo catalogues for blind challenges in precision cosmology
Authors: Garrison Lehman H , Eisenstein Daniel J 
Published: February 2019

ABSTRACT
We present a method for generating suites of dark matter halo catalogues with only a few N-body simulations, focusing on making small changes to the underlying cosmology of a simulation with high precision. In the context of blind challenges, this allows us to re-use a simulation by giving it a new cosmology after the original cosmology is revealed. Starting with full N-body realizations of an original cosmology and a target cosmology, we fit a transfer function that displaces haloes in the original so that the galaxy/HOD power spectrum matches that of the target cosmology. This measured transfer function can then be applied to a new realization of the original cosmology to create a new realization of the target cosmology. For a 1 per cent change in σ8, we achieve 0.1 per cent accuracy to $k = 1\, h\, \mathrm{Mpc}^{-1}$ in the real-space power spectrum; this degrades to 0.3 per cent when the transfer function is applied to a new realization. We achieve similar accuracy in the redshift-space monopole and quadrupole. In all cases, the result is better than the sample variance of our $1.1\, h^{-1}\, \mathrm{Gpc}$ simulation boxes.
Secondary Overtriage in Patients with Complicated Mild Traumatic Brain Injury: An Observational Study and Socioeconomic Analysis of 1447 Hospitalizations
Authors: Dengler Bradley A , Plaza-Wüthrich Sonia , Chick Robert C , Muir Mark T , Bartanusz Viktor 
Published: February 2019

Abstract

BACKGROUND
Secondary overtriage is a problematic phenomenon because it creates unnecessary expense and potentially results in the mismanagement of healthcare resources. The rates of secondary overtriage among patients with complicated mild traumatic brain injury (cmTBI) are unknown.

OBJECTIVE
To determine the rate of secondary overtriage among patients with cmTBI using the institutional trauma registry.

METHODS
An observational study using retrospective analysis of 1447 hospitalizations including all consecutive patients with cmTBI between 2004 and 2013. Data on age, sex, race/ethnicity, insurance status, GCS, Injury Severity Score (ISS), Trauma Injury Severity Score, transfer mode, overall length of stay (LOS), LOS within intensive care unit, and total charges were collected and analyzed.

RESULTS
Overall, the rate of secondary overtriage among patients with cmTBI was 17.2%. These patients tended to be younger (median: 41 vs 60.5 yr; P < .001), have a lower ISS (9 vs 16; P < .001), and were more likely to be discharged home or leave against medical advice.

CONCLUSION
Our findings provide evidence to the growing body of literature suggesting that not all patients with cmTBI need to be transferred to a tertiary care center. In our study, these transfers ultimately incurred a total cost of $13 294 ($1337 transfer cost) per patient.
Incentive Pay and Systemic Risk
Authors: Albuquerque Rui , Cabral Luís , Guedes José 
Published: February 2019

AbstractWe show that, in the presence of correlated investment opportunities across firms, risk sharing between firm shareholders and firm managers leads to compensation contracts that include relative performance evaluation. These contracts bias investment choices toward correlated investment opportunities, and thus create systemic risk. Furthermore, we show that leverage amplifies all such effects. In the context of the banking industry, we analyze recent policy recommendations for firm managerial pay and show how shareholders optimally undo the policies’ intended effects.Received October 31, 2017; editorial decision August 21, 2018 by Editor Wei Jiang. Authors have furnished an Internet Appendix, which is available on the Oxford University Press Web site next to the link to the final published paper online.
Interhospital variation in mortality among patients with systemic lupus erythematosus and sepsis in the USA
Authors: Tektonidou Maria G , Dasgupta Abhijit , Ward Michael M 
Published: February 2019

Abstract

Objective
To determine whether the risk of mortality in patients with SLE hospitalized with sepsis varies among hospitals in the USA.

Methods
We used the National Inpatient Sample (2002–2011) to obtain national population-based data on outcomes for adults with SLE admitted with sepsis, and compared it with that for patients without SLE admitted with sepsis at the same hospital. We computed expected mortality based on patient demographic characteristics, comorbidities and major organ dysfunction, and calculated observed/expected (O/E) mortality ratios separately for patients with SLE and without SLE for each hospital. We then computed the ratio of these O/E ratios within hospitals to assess relative SLE mortality. We considered hospitals with a risk ratio (RR) of ⩾2.0 as having high relative SLE mortality.

Results
Among 424 hospitals that treated a total of 4024 patients with SLE and sepsis, the risk of in-hospital mortality varied from 0% to 60% (median 11.1%). The RR ranged from 0 to 9.75, with a median of 0.84, indicating that O/E mortality was similar in patients with and without SLE at the average hospital. Sixty-one hospitals (14.4%) had a RR of ⩾2.0, indicating higher mortality among patients with SLE. Hospitals that on average treated ⩾3.9 patients with SLE and sepsis annually were less likely to have a RR of ⩾2.0 than hospitals that treated fewer patients (10% vs 17%; P = 0.004).

Conclusion
Mortality among patients with SLE and sepsis varied widely between hospitals, and was lower at hospitals that treated more of these patients.
Paget disease of the vulva
Authors: Johnson Jennifer , O'Laughlin Danielle 
Published: February 2019

ABSTRACT
Vulvar Paget disease (VPD) is an unusual and rare adenocarcinoma that can be challenging to diagnose. Although the condition has a high treatment success rate, it can be associated with underlying malignancy, recurrence rates can be high, and patients often need regular and frequent follow-up. The article describes a woman whose nonresolving, pruritic vulvar lesion was found to be VPD on biopsy.
Extracorporeal Life Support for Severe Acute Chest Syndrome in Adult Sickle Cell Disease: A Preliminary Report
Authors: Boissier Florence , Bagate François , Schmidt Matthieu , Labbé Vincent , Kimmoun Antoine , Fartoukh Muriel , Mekontso Dessap Armand 
Published: February 2019

Objectives:
Extracorporeal life support could be helpful for severe acute chest syndrome in adults sickle cell disease, because of the frequent hemodynamic compromise in this setting, including acute pulmonary vascular dysfunction and right ventricular failure. The aim of this study was to report the extracorporeal life support experience for severe acute chest syndrome in four referral centers in France.

Design:
The primary endpoint of this multicentric retrospective study was ICU survival of patients with severe acute chest syndrome managed with extracorporeal life support. Secondary endpoints included comparisons between survivors and nonsurvivors.

Setting:
We performed this study between January 2009 and July 2017 in four referral centers in France.

Patients:
We included adult patients (age > 18 yr) with sickle cell disease, admitted for severe acute chest syndrome and who required extracorporeal life support during the ICU stay.

Interventions:
The study was observational.

Measurements and Main Results:
Over the 8-year period, 22 patients with sickle cell disease required extracorporeal life support for severe acute chest syndrome, including 10 (45%) veno-venous and 12 (55%) veno-arterial extracorporeal life support. In-ICU mortality was high (73%). Nonsurvivors had a higher severity at extracorporeal life support implantation, as assessed by their Vasoactive-Inotrope Score and number of organ failures.

Conclusions:
Our study shows that outcome is impaired in sickle cell disease patients receiving extracorporeal life support while in severe multiple organ failure. Further studies are needed to evaluate selection criteria in this setting.
Demyelinating Neuropathy in a Patient Treated With Revusiran for Transthyretin (Thr60Ala) Amyloidosis
Authors: Zanazzi George , Arshad Muhammad , Maurer Mathew S. , Brannagan Thomas H. , Tanji Kurenai 
Published: February 2019

Abstract
Transthyretin amyloidosis patients develop length-dependent peripheral neuropathy, autonomic dysfunction, and restrictive cardiomyopathy associated with deposition of amyloid fibrils in these tissues. Despite advances in management over the past decade, this disorder causes profound debilitation and ultimately proves fatal. In this report, we describe a man with late-onset cardiac amyloidosis due to a transthyretin Thr60Ala mutation who was treated with an investigational RNAi therapeutic, revusiran, which targets hepatic transthyretin production. Sixteen months into treatment, he developed bilateral lower-extremity weakness and numbness, worsening balance, difficulty manipulating objects with his hands, and finger numbness. Nerve conduction studies were consistent with multifocal demyelinating neuropathy. Intravenous immunoglobulin therapy improved sensation in his hands and feet, and improved hand dexterity. A sural nerve biopsy demonstrated demyelination with substantial axonal loss in the absence of histologically detectable endoneurial amyloid deposition. This case expands the clinicopathologic spectrum of transthyretin amyloidosis and may represent complex disease and treatment effects.