bluuebunny/crossref_metadata_2025_split huggingface dataset:
In silico prediction of nonpermissive HLA-DPB1 mismatches in unrelated HCT by functional distance
Authors: Arrieta-Bolaños Esteban , Crivello Pietro , Shaw Bronwen E. , Ahn Kwang Woo , Wang Hai-Lin , Verneris Michael R. , Hsu Katharine C. , Pidala Joseph , Lee Stephanie J. , Fleischhauer Katharina , Spellman Stephen R. 
Published: July 2018

Key Points
Nonpermissive T-cell epitope group mismatches can be predicted in silico for any HLA-DPB1 allele by functional distance scores. In silico–predicted nonpermissive DPB1 mismatches are associated with mortality and GVHD after 8/8 matched HCT.
Relationship between ambient light and glucose metabolism in healthy subjects
Authors: Hirakawa Hirofumi , Terao Takeshi , Hatano Koji , Kohno Kentaro , Ishii Nobuyoshi 
Published: July 2018

Abstract
Background
Given the reported inverse association between light and depressive mood, ambient light may also be associated with some of the brain regions in healthy subjects. The present study aims to investigate the effects of ambient light on glucose metabolism in the brain. We used the data of 28 healthy participants of the no intervention group from our previous randomized controlled trial and analyzed the association between ambient light and [18F]-FDG uptake in the brain.

Results
A whole brain analysis revealed a cluster of [18F]-FDG uptake that was significantly and inversely associated with log-transformed ambient light in the left culmen of the left cerebellum vermis. After adjustment for age, gender and serum melatonin levels, there remained a significant cluster of [18F]-FDG uptake with log-transformed ambient light in the left cerebellar vermis.

Conclusions
The present findings suggest that the uptake of [18F]-FDG is significantly and inversely associated with ambient light in the left cerebellar vermis in healthy subjects. The cerebellar vermis may be involved in mood suppression which may be alleviated by light exposure where glucose uptake and metabolism in this area are decreased.
Trial Registration This study is a secondary analysis of the previous randomized study which was
registered as UMIN000007537. Retrospectively registered (March 20th, 2012).
Quality of Clinician-Reported Cancer History When Ordering Genetic Testing
Authors: LaDuca Holly , McFarland Rachel , Gutierrez Stephanie , Yussuf Amal , Ho Nadia , Pepper Jonathan , Reineke Patrick , Cain Taylor , Blanco Kirsten , Horton Carolyn , Dolinsky Jill S. 
Published: July 2018

Purpose Clinical history data reported on test requisition forms (TRFs) for hereditary cancer multigene panel testing (MGPT) are routinely used by genetic testing laboratories. More recently, publications have incorporated TRF-based clinical data into studies exploring yield of testing by phenotype and estimating cancer risks for mutation carriers. We aimed to assess the quality of TRF data for patients undergoing MGPT. Patients and Methods Ten percent of patients who underwent hereditary cancer MGPT between January and June 2015 at a clinical laboratory were randomly selected. TRF-reported cancer diagnoses were evaluated for completeness and accuracy for probands and relatives using clinical documents such as pedigrees and chart notes as the comparison standard in cases where these documents were submitted after the time of test order. Results TRF-reported cancer sites and ages at diagnosis were complete for > 90.0% of proband cancer diagnoses overall, and the completion rate was even higher (> 96.0%) for breast, ovarian, colorectal, and uterine cancers. When reported, these data were accurate on TRFs for > 99.5% of proband cancer sites and > 97.5% of proband ages at diagnosis. Cancer site and age at diagnosis data were also complete on the TRF for the majority of cancers among first- and second-degree relatives. Completeness decreased as relation to the proband became more distant, whereas accuracy remained high across all degrees of relation. Conclusion Data collected as part of cancer genetic risk assessment is completely and accurately reported on TRFs for the majority of probands and their close relatives and is comparable to information directly obtained from clinic notes, particularly for breast and other cancers commonly associated with hereditary cancer syndromes.
Rasip1 controls lymphatic vessel lumen maintenance by regulating endothelial cell junctions
Authors: Liu Xiaolei , Gu Xiaowu , Ma Wanshu , Oxendine Michael , Gil Hyea Jin , Davis George E. , Cleaver Ondine , Oliver Guillermo 
Published: July 2018

ABSTRACT
Although major progress in our understanding of the genes and mechanisms that regulate lymphatic vasculature development has been made, we still do not know how lumen formation and maintenance occurs. Here, we identify the Ras-interacting protein Rasip1 as a key player in this process. We show that lymphatic endothelial cell-specific Rasip1-deficient mouse embryos exhibit enlarged and blood-filled lymphatics at embryonic day 14.5. These vessels have patent lumens with disorganized junctions. Later on, as those vessels become fragmented and lumens collapse, cell junctions become irregular. In addition, Rasip1 deletion at later stages impairs lymphatic valve formation. We determined that Rasip1 is essential for lymphatic lumen maintenance during embryonic development by regulating junction integrity, as Rasip1 loss results in reduced levels of junction molecules and defective cytoskeleton organization in vitro and in vivo. We determined that Rasip1 regulates Cdc42 activity, as deletion of Cdc42 results in similar phenotypes to those seen following the loss of Rasip1. Furthermore, ectopic Cdc42 expression rescues the phenotypes in Rasip1-deficient lymphatic endothelial cells, supporting the suggestion that Rasip1 regulates Cdc42 activity to regulate cell junctions and cytoskeleton organization, which are both activities required for lymphatic lumen maintenance.
Embryonic Tbx3+ cardiomyocytes form the mature cardiac conduction system by progressive fate restriction
Authors: Mohan Rajiv A. , Mommersteeg Mathilda T. M. , Domínguez Jorge N. , Choquet Caroline , Wakker Vincent , de Gier-de Vries Corrie , Boink Gerard J. J. , Boukens Bastiaan J. , Miquerol Lucile , Verkerk Arie O. , Christoffels Vincent M. 
Published: July 2018

ABSTRACT
A small network of spontaneously active Tbx3+ cardiomyocytes forms the cardiac conduction system (CCS) in adults. Understanding the origin and mechanism of development of the CCS network are important steps towards disease modeling and the development of biological pacemakers to treat arrhythmias. We found that Tbx3 expression in the embryonic mouse heart is associated with automaticity. Genetic inducible fate mapping revealed that Tbx3+ cells in the early heart tube are fated to form the definitive CCS components, except the Purkinje fiber network. At mid-fetal stages, contribution of Tbx3+ cells was restricted to the definitive CCS. We identified a Tbx3+ population in the outflow tract of the early heart tube that formed the atrioventricular bundle. Whereas Tbx3+ cardiomyocytes also contributed to the adjacent Gja5+ atrial and ventricular chamber myocardium, embryonic Gja5+ chamber cardiomyocytes did not contribute to the Tbx3+ sinus node or to atrioventricular ring bundles. In conclusion, the CCS is established by progressive fate restriction of a Tbx3+ cell population in the early developing heart, which implicates Tbx3 as a useful tool for developing strategies to study and treat CCS diseases.
DWI-MRI vs CT in gastric MALT lymphoma—preliminary results in 19 patients
Authors: Berzaczy Dominik , Staudenherz Anton , Raderer Markus , Weber Michael , Mayerhoefer Marius E. 
Published: July 2018

Objective:
To assess the diagnostic performance of [F18] fluoro-2-desoxy-D-glucose positron emission tomography/CT [(18F) FDG-PET/CT] compared to diffusion-weighted imaging (DWI)-MRI of lesion detection in patients with non-FDG avid gastric mucosa-associated lymphoid tissue (MALT) lymphoma.

Methods:
19 patients with histologically proven gastric MALT lymphoma were included in this prospective Institutional Review Board-approved study. Patients underwent [18F]-FDG-PET/CT and consecutive MRI/DWI. Images were evaluated for the presence of gastric lesions in two anatomically defined groups (region 1: cardia, body, fundus; region 2: antrum, pyloric region) by two senior board-certified radiologists, in an observer-blinded manner. Overall accuracy relative to the reference standard (histology obtained by biopsy) was calculated for each reader and a consensus rating.

Results:
We found a statistically significant higher accuracy of lesion detection for lesions in region 1 (p = 0.030) and 2 (p = 0.070) for DWI-MRI (100%/78.9%) than for CT (68.4%/42.1%).

Conclusion:
DWI-MRI seems to be superior accurate to CT for lesion detection in non-FDG avid gastric MALT lymphoma.

Advances in knowledge:
DWI-MRI seems to be an alternative reliable imaging method for locoregional disease evaluation of non-FDG avid gastric MALT lymphoma.
Quantile-Based Risk Sharing
Authors: Embrechts Paul , Liu Haiyan , Wang Ruodu 
Published: July 2018

We address the problem of risk sharing among agents using a two-parameter class of quantile-based risk measures, the so-called range-value-at-risk (RVaR), as their preferences. The family of RVaR includes the value-at-risk (VaR) and the expected shortfall (ES), the two popular and competing regulatory risk measures, as special cases. We first establish an inequality for RVaR-based risk aggregation, showing that RVaR satisfies a special form of subadditivity. Then, the Pareto-optimal risk sharing problem is solved through explicit construction. To study risk sharing in a competitive market, an Arrow–Debreu equilibrium is established for some simple yet natural settings. Furthermore, we investigate the problem of model uncertainty in risk sharing and show that, in general, a robust optimal allocation exists if and only if none of the underlying risk measures is a VaR. Practical implications of our main results for risk management and policy makers are discussed, and several novel advantages of ES over VaR from the perspective of a regulator are thereby revealed.The e-companion is available at https://doi.org/10.1287/opre.2017.1716 .
Technical Note—Multiproduct Pricing Under the Generalized Extreme Value Models with Homogeneous Price Sensitivity Parameters
Authors: Zhang Heng , Rusmevichientong Paat , Topaloglu Huseyin 
Published: July 2018

We consider unconstrained and constrained multiproduct pricing problems when customers choose according to an arbitrary generalized extreme value (GEV) model and the products have the same price sensitivity parameter. In the unconstrained problem, there is a unit cost associated with the sale of each product. The goal is to choose the prices for the products to maximize the expected profit obtained from each customer. We show that the optimal prices of the different products have a constant markup over their unit costs. We provide an explicit formula for the optimal markup in terms of the Lambert-W function. In the constrained problem, motivated by the applications with inventory considerations, the expected sales of the products are constrained to lie in a convex set. The goal is to choose the prices for the products to maximize the expected revenue obtained from each customer, while making sure that the constraints for the expected sales are satisfied. If we formulate the constrained problem by using the prices of the products as the decision variables, then we end up with a nonconvex program. We give an equivalent market-share-based formulation, where the purchase probabilities of the products are the decision variables. We show that the market-share-based formulation is a convex program, the gradient of its objective function can be computed efficiently, and we can recover the optimal prices for the products by using the optimal purchase probabilities from the market-share-based formulation. Our results for both unconstrained and constrained problems hold for any arbitrary GEV model. The e-companion is available at https://doi.org/10.1287/opre.2018.1740 .
ESCRAVIDÃO CONTEMPORÂNEA NO CAMPO E CIDADES: UM RETRATO DE MINAS GERAIS ENTRE 2000 A 2015
Authors: Ferreira Gustavo Henrique Cepolini , Santos Cleiton Ferreira dos 
Published: July 2018

A escravidão é considerada um fenômeno social e territorial que emerge nos primórdios das civilizações antigas, que empregavam o trabalho escravo para a execução de tarefas mais pesadas e rudimentares. No entanto, no decorrer da história, e também na contemporaneidade, pode-se encontrar inúmeras práticas análogas à escravidão. Diante do exposto, estabeleceu-se como objetivo geral estudar o contexto que envolve o trabalho escravo contemporâneo em Minas Gerais, entre o período de 2000 a 2015, para tal visa-se discutir a situação de Minas Gerais diante das ocorrências de trabalho escravo ocorridas. Salienta-se ainda, que a maioria das ocorrências tem origem no campo, devido a fatores socioeconômicos em função da contrarreforma agrária em vigor no país. A abordagem metodológica consistiu em pesquisa bibliográfica, tratamento de dados oriundos do Ministério do Trabalho e Emprego e da Comissão Pastoral da Terra, elaboração de mapas, gráficos e tabelas. Assim, é possível inferir que o trabalho escravo contemporâneo infringe as legislações e desencadeia um processo perverso na frente pioneira e também em outras regiões do Brasil, respaldado especialmente pelos mecanismos de acumulação primitiva, os quais são incorporados à reprodução ampliada do capital. Por fim, os resultados demostram que nos últimos anos, o número de ocorrências envolvendo trabalhadores em situação de escravidão no Brasil tem diminuído, enquanto que em Minas Gerais constata-se um significativo aumento dos trabalhadores escravos, tanto no campo quanto nos centros urbanos.
An Evaluation of Intravenous Vitamin K for Warfarin Reversal: Are Guideline Recommendations Being Followed?
Authors: Rivosecchi Ryan M. , Garavaglia Jeffrey , Kane-Gill Sandra L. 
Published: July 2018

Background Vitamin K antagonists (eg, warfarin) remain the mainstay of anticoagulation therapy in the United States, with over 22 million prescriptions being filled annually. Unfortunately, warfarin therapy is difficult to manage and increases bleeding risk. The 2012 American College of Chest Physicians guidelines created a warfarin reversal algorithm that suggested the stringent use of intravenous vitamin K. Objective The purpose of this evaluation was to determine the rates of adherence with guideline recommendations in clinical practice. Method A convenience sample of 3 months of intravenous vitamin K medication administration data (September to November 2013) was obtained to conduct a retrospective review. Patients with underlying hepatic dysfunction or lack of warfarin therapy were excluded. Vitamin K use was evaluated for consistency with the 2012 guidelines. Results A total of 364 patients were reviewed and 119 were included. Vitamin K utilization was consistent with guideline recommendations for a total of 30 (25.2%) patients. The most common site of active bleeding requiring reversal was head bleeds, consisting of 56.6% of bleeds. A single dose of 10 mg of vitamin K was the most frequently used dosing strategy. Fresh frozen plasma (73.3%) and four-factor prothrombin complex concentrate (36.7%) were the most commonly used factor products. Conclusion This evaluation demonstrates that there is a difference between clinical judgment and guideline adherence. True adherence with the guidelines may not be necessary; however, there is room for improvement in both the appropriateness and safety of intravenous vitamin K use.
Use of ViperSlide Lubricant to Extract Entrapped Sheath after Severe Radial Artery Spasm during Coronary Angiography
Authors: Fidone Erica , Price Justin , Gupta Rajiv 
Published: July 2018

Radial artery spasm is a known complication of transradial cardiac catheterization. However, severe spasm with sheath entrapment is rare. We describe such a case, and the condition's response to an alternative removal method after conventional efforts failed.
A 68-year-old man presented for coronary angiography. We introduced a 5F sheath into the right radial artery, but, because of severe arterial spasm, we could not aspirate blood from the sheath or retract it. We sedated the patient and waited for the spasm to subside; however, the radial sheath remained entrapped. Nitroglycerin injection enabled blood aspiration and vasodilator injection, but not sheath removal. Finally, we injected ViperSlide lubricant into the sheath for its rapid, easy extraction.
When sedation and vasodilator therapy fail, we recommend using ViperSlide for radial sheath removal before applying nerve block or general anesthesia.
Experiment Research on Pulverized Coal Combustion in the Tuyere of Oxygen Blast Furnace
Authors: Chai Yi-fan , Zhang Jian-liang , Shao Qiu-jun , Ning Xiao-jun , Wang Kai-di 
Published: July 2018

Abstract
The actual combustion rate of pulverized coal in the blast furnace tuyere is hard to be measured. In this research, the combustion rate of pulverized coal injected into oxygen blast furnace was obtained by a new equipment. This equipment can simulate the actual blast furnace well, and the relationship between pulverized coal injection (PCI) ratio and AO/C
was established by mathematical deduction. The experimental results show that the best combustibility of the four pulverized coals is C, and when the coal injection ratio is 350 kg/tHM, the combustion rate can be reached 79%, while the combustion rate of B in the same case is only 45.6%. With the increase of AO/C
, the relative amount of oxygen to coal increases, the combustion conditions become better, and combustion rate of the pulverized coal increases. In addition, under the condition of high temperature and rapid combustion, with the increase of coal’s volatile, the combustion rate increases and the corresponding PCI ratio is also increased. By using the new equipment, the unburned coal under the oxygen blast furnace conditions can be collected for further study.
Phosphate Capacities of CaO–FeO–SiO2–Al2O3/Na2O/TiO2 Slags
Authors: Li Fengshan , Li Xianpeng , Zhang Yanling , Gao Ming 
Published: July 2018

Abstract
To effectively increase the dephosphorization efficiency of hot metals or the previous stage in the converter steelmaking process, phosphate capacities

(

C

P
O

4

3
−

)

{\rm{(}}{{\rm{C}}_{{\rm{PO}}_4^{3 - }}})

of CaO–FeO–SiO2–Al2O3/Na2O/TiO2 slags at 1300–1400°C were examined by laboratory experiments using equilibrating slag and pure solid iron foil. The data suggested that

(

C

P
O

4

3
−

)

{\rm{(}}{{\rm{C}}_{{\rm{PO}}_4^{3 - }}})

increases with decreasing temperature and increasing slag basicity. Compared to basicity, temperature considerably affected the phosphate capacities and tended to be the most important factor. The phosphate capacities of slag considerably decreased at a high temperature of 1400°C even under high binary basicity as well as high contents of Na2O and FeO. Moreover, with the increase in the content of FeO and Al2O3 in the slag,

(

C

P
O

4

3
−

)

{\rm{(}}{{\rm{C}}_{{\rm{PO}}_4^{3 - }}})

decreased. A low content of Na2O led to the increase in the phosphate capacities of slag, particularly at low temperatures of 1300–1350°C. The content of TiO2 in the slag considerably exhibited a weaker effect on

(

C

P
O

4

3
−

)

{\rm{(}}{{\rm{C}}_{{\rm{PO}}_4^{3 - }}})

. Furthermore, by regression analysis,

(

C

P
O

4

3
−

)

{\rm{(}}{{\rm{C}}_{{\rm{PO}}_4^{3 - }}})

was expressed as a function of the temperature and slag compositions as follows:

logC

PO

4

3
−

=
0.041
(
%
CaO
)
−
0.086
log
(
%
FeO
)
−
0.024
(
%

SiO
2

)

−
0.02
(
%

Al
2

O
3

)
+
0.067
(
%

Na
2

O
)
+
0.039
(
%

TiO
2

)

+
56767
/
T
−
14.58
,
(
R
=
0.978
)

\eqalign{&{{\rm{log}}{{\rm{C}}_{{\rm PO}_4^{3 - }} = 0.041( \% {\rm CaO}) - 0.086{\rm log}({\rm{ \% }}{\rm FeO})} - 0.024( \% {\rm Si{O_2}})} \cr &{{ - 0.02({\rm{ \% }}{\rm A{l_2}{O_3})}} { + 0.067( \% {\rm N{a_2}O)} + 0.039( \% {\rm Ti{O_2})}}} \cr &+ 56767/{\rm T} - 14.58, ({\rm R} = 0.978)}}
Legislative exploration of domestic violence in the People’s Republic of China: A sociosemiotic perspective
Authors: Cheng Le , Wang Xin 
Published: July 2018

Abstract
Battles against domestic violence in the People’s Republic of China (hereafter P. R. C.) have been carried out since 1995. In this study, legislative progression of laws related to domestic violence is first examined and clarified; second, findings from the legislative review are investigated on the basis of civil and criminal cases; third, the interaction among social and traditional norms, legislation, and judicial outcomes is explored and interpreted from a sociosemiotic perspective. It is found in this study that: 1) legislation and judicial practices of domestic violence in the P. R. C. are closely intertwined with social and traditional norms; 2) there is a gap between judicial practices dealing with domestic violence and the legislation; 3) the Anti-Domestic Violence Law offers a notch for state powers to embrace the familial relationship and to safeguard a victim.
Considerations on the Experimental Calibration of the Fall Cone Test
Authors: Llano-Serna Marcelo A. , Farias Márcio M. , Pedroso Dorival M. , Williams David J. , Sheng Daichao 
Published: July 2018

Abstract
The fall cone test is widely used in soil mechanics to determine the liquid limit of fine-grained soils as an aid to soil classification. The test can also be used to obtain the undrained shear strength of a fine-grained soil, based on the “cone factor,” K. Reports from different authors show K values ranging from 0.4–1.33. Differences are mostly attributed to the cone surface roughness. This article presents a reinterpretation of several experimental observations available in the literature. It is observed that besides the cone roughness, testing methods have a clear influence when calibrating the fall cone for determining the undrained shear strength of materials with low and very low consistency. The results show that existing K reports should be extrapolated with care. Finally, we propose a series of recommendations and good practices for future calibrations.
Determination of Residual Stresses Utilizing the Variation of Hardness at Elastic-Plastic Indentation
Authors: Larsson Per-Lennart 
Published: July 2018

Abstract
Material hardness is independent of residual stresses at predominantly plastic deformation in the region of contact between an indenter and the material. This is an important fact, as such a situation is relevant for most metals and alloys. It has, however, been established that when elastic and plastic deformations are of equal magnitude, this independence is lost. This fact complicates residual stress determination in such a situation, pertinent to materials such as ceramics and polymers, but it also provides additional important information for performing such a task in an accurate manner. Presently, a relevant formula for taking advantage of this information is presented. The formula is based on previous results pertinent to indentation analyses of stress-free materials. The predictions are compared to finite element results from previous studies describing cone indentation of materials with residual stresses. The analysis is restricted to classical elastoplasticity.