bluuebunny/crossref_metadata_2025_split huggingface dataset:
Machine perfusion of donor kidneys may reduce graft rejection
Authors: Samoylova Mariya L. , Nash Amanda , Kuchibhatla Maragatha , Barbas Andrew S. , Brennan Todd V. 
Published: September 2019

AbstractRecent evidence suggests that hypothermic machine perfusion of donor kidneys reduces delayed graft function (DGF). This study addresses the effect of machine perfusion (MP) on allograft rejection in the United States. We assembled a retrospective cohort of patients undergoing kidney‐alone transplants in the UNOS database from June 30, 2004 to May 31, 2017. DGF was defined as dialysis requirement in the first week post‐transplant; graft rejection was defined at 6 months and 1 year. Multivariable logistic regression adjusted for recipient and donor factors evaluated the effect of MP on DGF and graft rejection. Records for 79 300 kidney transplants meeting inclusion criteria were abstracted, 42% of which underwent MP. MP kidneys came from older donors, were more likely to have been obtained following donation after cardiac death, and had longer cold ischemic times. Rates of DGF and rejection were similar between MP and static storage kidneys. Following adjustment, recipients of MP kidneys were less likely to experience rejection at 1 year (OR 0.91 [95% CI 0.86‐0.97] P = .002), but not at 6 months post‐transplantation (OR 0.94 [0.88‐1.02] P = .07). This effect persisted following adjustment for cold ischemic time. This study adds to the accumulating evidence demonstrating improved outcomes following MP of kidneys. We encourage protocolized consideration of MP for kidney grafts.
Role of 3D transesophageal echocardiography in transcatheter closure of atrial septal aneurysms
Authors: Taha Fatma , Elshedoudy Sahar 
Published: September 2019

AbstractBackgroundThree dimensional transesophageal echocardiography (3DTEE) is superior to two dimensional transesophageal echocardiography (2DTEE) as it provides all atrial septal information from a single view.AimTo evaluate 3DTEE role in analysis of atrial septal aneurysm (ASA) and in device closure guiding.MethodsThree dimensional transesophageal echocardiography were recorded with Vivid*E9,GE system over 14 months. ASAs were classified into 4 types (A: with PFO, B: with one ASD, C: with 2 ASDs, and D: with multiple fenestrations). Each aneurysm was assessed according to its type, shape, dimensions, orientation, aneurysmal tissue, and the surrounding rims. All patients passed to transcatheter aneurysm closure.ResultsA total of 26 patients with ASAs were assessed (7 imperforated aneurysms excluded). The remaining 19 patients’ age was 12.84 ± 5.82years. Four patients had type A aneurysms, 6 had type B, 4 had type C, and 5 had type D. 3DTEE demonstrated oval aneurysms in 17 patients. The orientation was oblique in 8 patients, vertical in 7, and horizontal in 4. The ASAs dimensions were 23.5 ± 5.1, 23.2 ± 5.1, and 22.0 ± 4.0 mm for oblique, vertical, and horizontal axes. Percutaneous closure succeeded in 18 patients. Balloon sizing was used in 4 patients. Devices used were: In type A:PFO devices, in type B:ASO devices, in type C:two patients required two ASO devices in each patient and two patients required one cribriform device, and in type D:Cribriform devices used for three patients, PFO for one and ASO for one. LA, LUPV, and RUPV approaches were used. Aspirin was received for 6 months.ConclusionThree dimensional transesophageal echocardiography helps to select aneurysms suitable for transcatheter closure, select the suitable devices, and guide the transcatheter procedure.
A developmental synapomorphy of squamate reptiles
Authors: Stewart James R. , Blackburn Daniel G. 
Published: September 2019

AbstractThe reptilian clade Squamata is defined primarily by osteological synapomorphies, few of which are entirely unambiguous. Studies of developing squamate eggs have revealed a uniquely specialized feature not known to occur in any other amniotes. This feature—the yolk cleft/isolated yolk mass complex—lines the ventral hemisphere of the egg. During its formation, extraembryonic mesoderm penetrates the yolk and an exocoelom (the yolk cleft [YC]) forms in association with it, cutting off a thin segment of yolk (the “isolated yolk mass” [IYM]) from the main body of the yolk. The YC–IYM complex has been observed and described in more than 65 squamate species in 12 families. In viviparous species, it contributes to the “omphaloplacenta,” a type of yolk sac placenta unique to squamates. The only squamates known to lack the IYM are a few highly placentotrophic skinks with minuscule eggs, viviparous species in which it clearly has been lost. Given its absence in mammals, chelonians, crocodylians, and birds, the YC–IYM complex warrants recognition as a developmental synapomorphy of the squamate clade. As in extant viviparous lizards and snakes, the YC–IYM complex presumably contributed to the placenta of extinct viviparous squamates.
Irrigation and its effect on polyphagous shot hole borer attack
Authors: Umeda Colin , Eatough Jones Michele , Paine Timothy 
Published: September 2019

AbstractPolyphagous shot hole borer (PSHB), Euwallacea whitfordiodendrus (Schedl) (Coleoptera: Curculionidae, Scolytinae), is an ambrosia beetle that has recently invaded southern California, USA. This beetle successfully attacks and reproduces in a multitude of tree species. As direct control methods are limited, we investigated cultural management options, and sought to determine whether irrigation affects the number of attacks host trees experienced. If irrigation plays a role, cultural control methods could be recommended to managers and growers. Three separate experiments were conducted that monitored the number of attacks on trees with different levels of irrigation. Two experiments examined PSHB attacks in established landscape trees where irrigation was either present or absent. A third experiment used young potted box elder with irrigation controlled with timed emitters. In all three experiments, the level of irrigation received by the trees did not affect the number of attacks. The results suggest that changes in irrigation practices do not affect risk from PSHB attack.
Forecasting recoveries in debt collection: Debt collectors and information production
Authors: Kriebel Johannes , Yam Kevin 
Published: September 2019

AbstractRecent theoretical work suggests that debt collection agencies play an important role in gathering and processing debtor information. We study a comprehensive data set with information provided by original creditors and information gathered in third‐party debt collection. In line with the theoretical results, the initial information is sparse and the gathered information is essential for better‐informed predictions.
Abortion due to Bacillus safensis in a mare
Authors: Kelley D. E. , Hodo C. L. , Aceino A. , Lawhon S. D. , Hinrichs K. , Brinsko S. P. 
Published: September 2019

SummaryA 16‐year‐old Westphalian mare aborted a dead fetus at 7 months of gestation without prodromal signs. The chorioallantois was diffusely thickened and discoloured, with fibrinous plaques, congestion and haemorrhage. Small colonies of 1‐μm, Gram‐positive bacilli were scattered throughout the exudate overlying the chorionic epithelium, and within macrophages. Bacillus safensis was isolated from the fetal lungs and from a swab sample of the mare's uterus. This strain represents the first case of a B. safensis‐associated equine abortion and the first case of any infection caused by this bacterium.
Radiographic, computed tomographic and CT myelographic findings of an extensive cervical osteochondroma resulting in spinal cord compression at the atlanto‐occipital junction
Authors: Dixon J. J. , Anderson J. D. C. 
Published: September 2019

SummaryA 13‐year‐old, crossbred grey mare was referred for examination of a left‐sided head tilt and neck stiffness which had been noted for several months. Radiographic examination of the head revealed severe periarticular bone formation surrounding the dorsal and ventral margins of the atlanto‐occipital joint and a large multilobular bony mass encroaching on the guttural pouch. Computed tomographic examination confirmed a multiloculated bony mass invading the vertebral canal and causing marked spinal cord compression and displacement. Histologically, this was identified to be an osteochondroma and the horse was conservatively managed.
Demonstrating the impact of your teaching: benefits of Higher Education Academy Fellowship for librarians
Authors: George Sarah , Rowland Jennifer 
Published: September 2019

AbstractThis feature suggests that health librarians who teach or support Higher Education (HE) students can and should gain accreditation and recognition for their teaching by the route of HEA Fellowship. We outline the process by which Fellowship could be attained by those working within HE and those in NHS libraries who work with HE students, suggesting which aspects of librarianship practice could provide the necessary evidence for Fellowship. The synergies between Fellowship and Chartership are examined and the criteria for HEA (UK Professional Standards Framework or UKPSF) are mapped against those for Chartership (Professional Knowledge and Skills Base (PKSB).D.I.
From environmental DNA sequences to ecological conclusions: How strong is the influence of methodological choices?
Authors: Calderón‐Sanou Irene , Münkemüller Tamara , Boyer Frédéric , Zinger Lucie , Thuiller Wilfried 
Published: September 2019

AbstractAimEnvironmental DNA (eDNA) is increasingly used for analysing and modelling all‐inclusive biodiversity patterns. However, the reliability of eDNA‐based diversity estimates is commonly compromised by arbitrary decisions for curating the data from molecular artefacts. Here, we test the sensitivity of common ecological analyses to these curation steps, and identify the crucial ones to draw sound ecological conclusions.LocationValloire, French Alps.TaxonVascular plants and fungi.MethodsUsing soil eDNA metabarcoding data for plants and fungi from 20 plots sampled along a 1000‐m elevational gradient, we tested how the conclusions from three types of ecological analyses: (a) the spatial partitioning of diversity, (b) the diversity–environment relationship, and (c) the distance–decay relationship, are robust to data curation steps. Since eDNA metabarcoding data also comprise erroneous sequences with low frequencies, diversity estimates were further calculated using abundance‐based Hill numbers, which penalize rare sequences through a scaling parameter, namely the order of diversity q (Richness with q = 0, Shannon diversity with q ~ 1, Simpson diversity with q = 2).ResultsWe showed that results from different ecological analyses had varying degrees of sensitivity to data curation strategies and that the use of Shannon and Simpson diversities led to more reliable results. We demonstrated that molecular operational taxonomic unit clustering, removal of polymerase chain reaction errors and of cross‐sample contaminations had major impacts on ecological analyses.Main conclusionsIn the Era of Big Data, eDNA metabarcoding is going to be one of the major tools to describe, model and predict biodiversity in space and time. However, ignoring crucial data curation steps will impede the robustness of several ecological conclusions. Here, we propose a roadmap of crucial curation steps for different types of ecological analyses.
Non‐canonical Raf‐1/p70S6K signalling in non–small‐cell lung cancer
Authors: Qiu Zhixin , Ye Bingwei , Zhao Shuang , Li Xin , Li Lei , Mo Ximing , Li Weimin 
Published: September 2019

AbstractLung cancer is the leading cause of cancer‐related death globally, with non–small‐cell lung cancer (NSCLC) being the predominant subtype. Overall survival remains low for NSCLC patients, and novel targets are needed to improve outcome. Raf‐1 is a key component of the Ras/Raf/MEK signalling pathway, but its role and downstream targets in NSCLC are not completely understood. Our previous study indicated a possible correlation between Raf‐1 levels and ribosomal protein S6 kinase (p70S6K) function. In this study, we aimed to investigate whether p70S6K is a downstream target of Raf‐1 in NSCLC. Raf‐1 was silenced in NSCLC cell lines by using small hairpin RNA, and Raf‐1 and p70S6K protein levels were measured via Western blot. p70S6K was then overexpressed following Raf‐1 knock‐down; then, cell proliferation, apoptosis and the cell cycle in NSCLC cell lines were examined. Tumour xenografts with NSCLC cells were then transplanted for in vivo study. Tumours were measured and weighed, and Raf‐1 and p70S6K expression, cell proliferation and apoptosis were examined in tumour tissues by Western blot, Ki‐67 staining and TUNEL staining, respectively. When Raf‐1 was silenced, p70S6K protein levels were markedly decreased in the A549 and H1299 NSCLC cell lines. A significant decrease in NSCLC cell proliferation, a profound increase in apoptosis and cell cycle arrest were observed in vitro following Raf‐1 knock‐down. Overexpression of p70S6K after Raf‐1 depletion effectively reversed these effects. Xenograft studies confirmed these results in vivo. In conclusion, Raf‐1 targets p70S6K as its downstream effector to regulate NSCLC tumorigenicity, making Raf‐1/p70S6K signalling a promising target for NSCLC treatment.
The p factor: genetic analyses support a general dimension of psychopathology in childhood and adolescence
Authors: Allegrini Andrea G. , Cheesman Rosa , Rimfeld Kaili , Selzam Saskia , Pingault Jean‐Baptiste , Eley Thalia C. , Plomin Robert 
Published: September 2019

BackgroundDiverse behaviour problems in childhood correlate phenotypically, suggesting a general dimension of psychopathology that has been called the p factor. The shared genetic architecture between childhood psychopathology traits also supports a genetic p. This study systematically investigates the manifestation of this common dimension across self‐, parent‐ and teacher‐rated measures in childhood and adolescence.MethodsThe sample included 7,026 twin pairs from the Twins Early Development Study (TEDS). First, we employed multivariate twin models to estimate common genetic and environmental influences on p based on diverse measures of behaviour problems rated by children, parents and teachers at ages 7, 9, 12 and 16 (depressive traits, emotional problems, peer problems, autism traits, hyperactivity, antisocial behaviour, conduct problems and psychopathic tendencies). Second, to assess the stability of genetic and environmental influences on p across time, we conducted longitudinal twin modelling of the first phenotypic principal components of childhood psychopathological measures across each of the four ages. Third, we created a genetic p factor in 7,026 unrelated genotyped individuals based on eight polygenic scores for psychiatric disorders to estimate how a general polygenic predisposition to mostly adult psychiatric disorders relates to childhood p.ResultsBehaviour problems were consistently correlated phenotypically and genetically across ages and raters. The p factor is substantially heritable (50%–60%) and manifests consistently across diverse ages and raters. However, residual variation in the common factor models indicates unique contributions as well. Genetic correlations of p components across childhood and adolescence suggest stability over time (49%–78%). A polygenic general psychopathology factor derived from studies of psychiatric disorders consistently predicted a general phenotypic p factor across development (0.3%–0.9%).ConclusionsDiverse forms of psychopathology generally load on a common p factor, which is highly heritable. There are substantial genetic influences on the stability of p across childhood. Our analyses indicate genetic overlap between general risk for psychiatric disorders in adulthood and p in childhood, even as young as age 7. The p factor has far‐reaching implications for genomic research and, eventually, for diagnosis and treatment of behaviour problems.
Efficacy of aqueous and oil formulations of a specific Metarhizium anisopliae isolate against Aphis craccivora Koch, 1854 (Hemiptera: Aphididae) under field conditions
Authors: Mweke Allan , Akutse Komivi Senyo , Ulrichs Christian , Fiaboe Komi Kouma Mokpokpo , Maniania Nguya Kalemba , Ekesi Sunday 
Published: September 2019

AbstractCowpea (Vigna unguiculata) production is constrained by biotic and abiotic factors, among which Cowpea aphid (Aphis craccivora) is ranked a key insect pest that severely limits its potential for provision of food and nutritional security to millions of people in sub‐Saharan Africa. The use of entomopathogenic fungi for A. craccivora management has been recently demonstrated at laboratory and field levels as alternative to synthetic insecticides, but with low adoption in Africa. This study assessed the efficacy of aqueous and oil formulations of Metarhizium anisopliae ICIPE 62 against A. craccivora under field conditions. Metarhizium anisopliae formulations and a commonly used insecticide Duduthrin® were applied using knapsack sprayers with target output of 350 L/ha. Data on aphid infestation levels were collected weekly. ICIPE 62 efficacy in inducing mortality was also assessed 24 hr post‐treatment coupled with mycosis test. Further, leaf and grain yields were determined. After six weeks post‐treatment in the wet season, there was no significant reduction in aphid density in fungus‐treated plots compared to control and Duduthrin®‐treated plots. However, in the dry season six weeks after applying the treatments, oil formulation spray resulted low aphid density compared to control and Duduthrin®‐treated plots. ICIPE 62 formulations did not negatively affect the natural enemies’ population. Leaf yield from the various treatments did not differ significantly in the wet season, but the two fungal formulations recorded higher yields in dry season compared to other treatments. Grain yields in wet and dry seasons were lower in control and Duduthrin®‐treated plots compared to both ICIPE 62 formulations. This study showed that both M. anisopliae ICIPE 62 formulations are effective in suppressing A. craccivora population under field conditions without adverse effects on its beneficial insects. The study also revealed that efficacy of fungal‐based biopesticides is highly dependent on environmental conditions.
Literature review and micro‐computed tomography analysis of natal teeth: A pilot study
Authors: Park Joon Soo , Patel Jilen , Seewoo Bhedita J. , King Nigel M. , Anthonappa Robert P. 
Published: September 2019

AbstractAimTo outline the current literature surrounding natal teeth, and then, in a pilot study, to evaluate natal teeth using micro‐computed tomography (micro‐CT) to determine their anatomical profile, and compare and contrast different analytical methods to assess natal teeth.Methods2 extracted natal teeth (mandibular central incisors) and 1 exfoliated mandibular primary central incisor were subjected to micro‐CT analysis.ResultsWithin natal teeth, there were no statistical differences in tooth mineral density (TMD) of both enamel and dentine (P > .05), whereas mandibular primary central incisors had a significantly higher TMD of both enamel and dentine in comparison with both natal tooth 1 and natal tooth 2 (P < .05). Mandibular primary central incisors had a greater thickness and volume of both enamel and dentine, but exhibited lower pulpal space volume.ConclusionMicro‐CT is an alternative and non‐invasive method to anatomically assess natal teeth. According to the pilot study, natal teeth exhibited lower TMD, decreased enamel and dentine thickness, and smaller pulpal space volume in comparison with mandibular primary incisor teeth. This pilot study creates a foundation to establish the collection and analysis of natal teeth on a larger scale over time using micro‐CT.
A first case of fixed drug eruption due to Tamsulosin
Authors: Montazer Fatemeh , Jahani Amiri Kousar , Mofarrah Ramina , Ahmadi Alborz , Nouripour Behzad , Mofarrah Ramin 
Published: September 2019

AbstractBackgroundFixed Drug Eruption (FDE) is a drug reaction involving the skin and less commonly the mucosal membranes. Tamsulosin is an alpha‐1 adrenergic receptor blocker used to treat benign prostatic hyperplasia. Dizziness and headache are among its most common side effects (Singapore Med J, 2018;59:336). Although cutaneous drug eruption has been reported with other alpha‐1 adrenergic receptor blockers.AimsDrug rash due to Tamsulosin is relatively uncommon (Singapore Med J, 2018;59:336). In this case we report an incidence of fixed drug eruption due to Tamsulosin.PatientsA 54 year old male, with benign prostatic hyperplasia was referred to our office for evaluation of certain eruptions, having developed his hyper‐pigmented patches after 2 weeks of using oral 0.4 mg Tamsulosin per day. Based on the clinical course and the skin biopsy we diagnosed the condition as Tamsulosin associated fixed drug eruption. The most important therapeutic measure was discontinuing Tamsulosin medication. Following this, his eruptions improved remarkably in a few days without complications.ResultsAccording to previous findings, there has been no case report on fixed drug eruption caused by Tamsulosin.ConclusionOur case is a relatively mild form of fixed drug eruption. Therefore it should be kept in mind that a severe cutaneous drug eruption might occur after Tamsulosin administration.
Eyebrow growth pattern analysis in patients with eyebrow hypotrichosis after receiving topical treatment: A retrospective study
Authors: Suchonwanit Poonkiat , Thammarucha Sasima 
Published: September 2019

AbstractBackgroundDifferences in growth patterns among the various parts of the eyebrow have been observed.AimsWe aimed to investigate changes in the hair density and diameter and analyze the eyebrow growth pattern of each eyebrow part (head, body, and tail) in patients with eyebrow hypotrichosis over a 24‐week course of topical treatment.Patients/MethodsA retrospective study of 48 patients who received treatment with bimatoprost 0.01% was conducted. Patient demographic data were collected; measurements of hair density and diameter in the different parts of the eyebrow were collected and statistically evaluated.ResultsThe tail of the eyebrow revealed the lowest baseline eyebrow density and diameter. Significant changes in eyebrow density (P = .01) and diameter (P = .01) were first detected in the tail at 4 and 16 weeks of treatment, respectively. The head and body showed a comparable growth pattern.ConclusionsThis study confirms the previous observations that hair density, diameter, pattern of growth, and hair growth cycle vary according to their anatomical location within the eyebrow. A better understanding of eyebrow growth pattern could provide the precise pathomechanism of eyebrow hypotrichosis leading to a standardized treatment protocol.
60 Years of March and Simon’s Organizations: An Empirical Examination of its Impact and Influence on Subsequent Research
Authors: Wilden Ralf , Hohberger Jan , Devinney Timothy M. , Lumineau Fabrice 
Published: September 2019

AbstractWe provide an analytic and systematic review of the impact of March and Simon’s seminalOrganizationson management research and discuss the book’s value for current research and propose future applications of it. Building on bibliometric and text‐mining approaches, our empirical analysis reveals that althoughOrganizationswas contextually based in the industrial milieu of the 1950s, its concepts have found ongoing resonance with scholars. Further, we find that much of this resonance appears to be driven by the ability of scholars in different ‘schools of thought’ to find useful insights from March and Simon’s generalized theoretical structure. However, we also observe that scholars have been selective in their usage of ideas from the book over the last 60 years. Based our analysis, we propose a particular set of future research areas, including a focus on new organizational forms and extending March and Simon’s ideas to multi‐level research, which can benefit from more holistically drawing onOrganizationsand connect its original ideas to address current management problems.