bluuebunny/crossref_metadata_2025_split huggingface dataset:
A New Synthetic Spiroketal: Studies on Antitumor Activity on Murine Melanoma Model In Vivo and Mechanism of Action In Vitro
Authors: Fuggetta Maria P. , Spanu Pietro , Ulgheri Fausta , Deligia Francesco , Carta Paola , Mannu Alberto , Trotta Veronica , De Cicco Rosanna , Barra Adriano , Zona Enrica , Morelli Franco 
Published: February 2019

Background:In a previous study, we synthesised a new spiroketal derivative, inspired to natural products, that has shown high antiproliferative activity, potent telomerase inhibition and proapoptotic activity on several human cell lines.Objective:This work focused on the study of in vivo antitumor effect of this synthetic spiroketal on a murine melanoma model. In order to shed additional light on the origin of the antitumor effect, in vitro studies were performed.Methods:Spiroketal was administered to B16F10 melanoma mice at a dose of 5 mg/Kg body weight via intraperitoneum at alternate days for 15 days. Tumor volume measures were made every 2 days starting after 12 days from cells injection. The effects of the spiroketal on tumor growth inhibition, apoptosis induction, and cell cycle modification were investigated in vitro on B16 cells. HIF1α gene expression, the inhibition of cells migration and the changes induced in cytoskeleton conformation were evaluated.Results:Spiroketal displayed proapoptotic activity and high antitumor activity in B16 cells with nanomolar IC50. Moreover it has shown to inhibit cell migration, to strongly reduce the HIF1α expression and to induce strongly deterioration of cytoskeleton structure. A potent dose-dependent antitumor efficacy in syngenic B16/C57BL/6J murine model of melanoma was observed with the suppression of tumor growth by an average of 90% at a dose of 5 mg/kg.Conclusion:The synthesized spiroketal shows high antitumor activity in the B16 cells in vitro at nM concentration and a dose-dependent antitumor efficacy in syngenic B16/C57BL/6J mice. The results suggest that this natural product inspired spiroketal may have a potential application in melanoma therapy.
A Current Perspective of Schistosomiasis in Association with Colorectal Carcinogenesis
Authors: Abdalkareem Eshtiyag Abdalla , Yin Khoo Boon 
Published: February 2019

Background:

Schistosomiasis is one of the parasitic infections that are often found in humans. More than approximately 200 million people are infected with Schistosomiasis in tropical and subtropical areas of Africa, South America and Asian countries. Literature has long been suggesting the correlation between Schistosomiasis and colorectal malignancy. There is a considerable directory supporting the etiological relation between Schistosoma japonicum infection and colorectal cancer in the Far East, however, the available data about the role of Schistosoma mansoni that can initiate the carcinogenesis of colorectal remain insignificant.

Objective:
As such, more studies of this disease should be conducted comprehensively for corporate social responsibility internationally.

Methods:
The present study reviewed the available data about the role of Schistosoma, including S. mansoni in association with the carcinogenesis of colorectal.

Results:
The study shows the possible evidence of epidemiology, pathology, molecules and immunopathology associated with Schistosomal infections and colorectal cancer. The infections are apparently getting little attention nor support worldwide due to the geographical barriers and some political issues because it mainly occurs in the people living in the bottom billion and happens in the endemic regions only.

Conclusion:
The in-depth study of this infectious disease will tailor early diagnosis, novel prescription drugs and cost-effective strategies for the treatment of infectious disease colorectal cancer, and hence eradicate the disease in the endemic regions.
First report of Fusarium proliferatum causing stem and root rot on lucky bamboo (Dracaena braunii) in Iraq
Authors: Lahuf A.A. 
Published: February 2019

Summary
Lucky bamboo (Dracaena braunii) is a popular ornamental plant in Iraq. Individuals of this plant showing stem and root rot symptoms were observed during a survey conducted from November 2015 to February 2016 in several nurseries in Kerbala province, Iraq. Based on morphological characteristics and sequence analyses of the internal transcribed spacer (ITS) region of the ribosomal DNA (rDNA), the pathogen was identified as Fusarium proliferatum. This is the first report of stem and root rot caused by F. proliferatum on lucky bamboo (D. braunii) in Iraq.
Semantic and cultural equivalence of the working alliance inventory short-revised scale for therapeutic alliance in family medicine: Lessons learned in Slovenia
Authors: Petek Davorina , Pušnik Ambrož , Selič Polona , Cedilnik-Gorup Eva , Trontelj Žan , Riou Marine , Yves Le Reste Jean 
Published: February 2019

Abstract

Introduction
Therapeutic alliance is a term most commonly associated with psychotherapeutic treatment, but recently its use has become increasingly significant in the other fields of medicine. An increasing amount of evidence implies that the quality of the therapeutic alliance between the doctor and patient substantially affects treatment outcomes. A European consensus chose the Working Alliance Inventory – Short Revised (WAI-SR) scale as the most efficient for European primary care. This paper presents the process of establishing the semantic and cultural equivalence of the two WAI-SR scales in Slovene.

Method
As a part of a larger international project, a group of four experts translated the two WAI SR scales (physician and patient versions) from English into Slovene. Twenty-six Slovenian family medicine doctors participated in the process of obtaining semantic, idiomatic, experiential and conceptual equivalence in translation using a Delphi consensus procedure. Afterward, a cultural equivalence was made to adapt the translations within the national context.

Results
Agreement on translation was achieved after two Delphi rounds. The back-translation and cultural equivalence were accomplished without major problems, with some minor additional linguistic corrections.

Conclusion
A Slovene version of the WAI-SR scale was successfully adapted and is available for further scale validation and research on therapeutic alliance.
Validation of the Slovenian version of short sense of coherence questionnaire (SOC-13) in multiple sclerosis patients
Authors: Stern Biljana , Socan Gregor , Rener-Sitar Ksenija , Kukec Andreja , Zaletel-Kragelj Lijana 
Published: February 2019

Abstract

Aim
To validate the Slovenian version (SOC-13-SVN) of Sense of Coherence 13-item instrument (SOC-13) in Slovenian multiple sclerosis (MS) patients.

Methods
A consecutive 134 Slovenian MS patients were enrolled in a cross-sectional study in 2013. The reliability of the SOC-13-SVN was assessed for internal consistency by Cronbach’s alpha coefficient (α), dimensionality by the confirmatory factor analysis (CFA), and criterion validity by Pearson correlation coefficient (r) between SOC-13-SVN global score and MSQOL-54 composite scores – Mental Health Composite score (MHC) and Physical Health Composite score (PHC).

Results
For the SOC-13-SVN instrument as a whole, internal consistency was high (αtotal=0.88) while it was low for three subscales (αcomprehensibility=0.79; αmanageability=0.66; αmeaningfulness=0.69). The results of the CFA confirmed a three-factor structure with good fit (RMSEA=0.059, CFI=0.953, SRMR=0.065), however, the correlations between the factors were very high (rcomprehensibility/manageability=0.938; rcomprehensibility/meaningfulness=0.811; rmanageability/meaningfulness=0.930). The criterion validity analysis showed a moderate positive strength of relationship between SOC-13-SVN global score and both MSQOL-54 composite scores (MHC: r=0.597, p<0.001; PHC: r=0.437, p<0.001).

Conclusion
Analysis of some psychometric properties confirmed that this instrument is a reliable and valid tool for use in Slovenian MS patients. Despite the three-dimensional structure of the instrument, the use of the global summary score is encouraged due to the low reliability of the subscale scores and high correlations between them.
Family as Value. The Model of a Family Moulded by Graduating Students
Authors: Przybysz-Zaremba Margaret 
Published: February 2019

ABSTRACT

Family is the most important value, which is present in the life of each individual. It was confirmed
by research conducted among graduating students of the secondary school, who placed family
and love at the highest place in the hierarchy of values, claiming that it is [at the same time] a
fundamental factor of well-functioning matrimony. Graduating students have plans connected
with entering into matrimony.

The studies conducted revealed that almost each of the respondents is going to establish [one’s
own] family and have progeny. The plans of respondents as for matrimony and procreation
concerned mainly the nature of their relationship, preferred type of their relationship, factors that
are crucial for entering into matrimony, features that a husband- or wife-to-be should possess,
age at which the respondents plan to have children, and the number of the children.

Analysis of the research revealed that matrimony is treated very seriously by the respondents,
and that they are planning to enter it [not until] graduating and obtaining a job offer. Love,
stability of life, and willingness to have progeny are the factors that are the most influential as
for moulding the family model among graduating students. On the other hand a lack of decision
concerning establishing a family is directly connected with the emergence of such factors as
betrayal, uncertainty of choosing [the right] partner, poor health condition, obtaining education,
attractive job.
Retinal metastasis of carcinoid presenting with headache: a case representation
Authors: Eleftheriou Andreas 
Published: February 2019

Background:
Headache is one of the most common somatic symptoms in patients who search emergency department (ER). Diagnosing and treating the most common headache disorders are not so difficult. Thus, recognizing some types of headaches, either primary or secondary, can be challenging.

Case Presentation:
We present an interesting and challenging case of a patient who referred to the ER because of a benign headache and proved to suffer from a metastatic tumor of the retina due to lung carcinoid.

Conclusion:
Unusual headache syndromes do not appear to be as rare in clinical practice as has been generally believed. To our knowledge, this is the first time to report a metastatic carcinoid of retina presenting with isolated headache and redness of sclera as a primary symptoms. Appropriate identification of the secondary cause of a headache is the key to successful treatment.
La memoria entre baldosas y ferrocarriles. Dos performances en torno a la historia cultural de Buenos Aires
Authors: González Malala 
Published: February 2019

El siguiente artículo indaga acerca de la articulación entre arte-ciudad a partir de dos performances que ponen en escena la memoria sobre la historia cultural de Buenos Aires. Problematizando las miradas sobre la ciudad tangible e intangible, y los modos de percibir el espacio público, estas propuestas aplican resistencias al olvido, en tanto focalizan su punto de vista en evocaciones de un pasado urbano latente. Nos interesa reflexionar sobre ellas, en tanto prácticas de memoria en tiempos efímeros, para pensarnos hoy como espectadores transeúntes y considerar que la experimentación de una dimensión estética de la ciudad es posible mediante estas prácticas performáticas. Volver a mirar a partir de una yuxtaposición entre pasado y presente, de eso se trata.Recibido: 17 de junio de 2017Aceptado: 15 de enero de 2018
Personajes y representación en un coloquio conventual novohispano del siglo XVIII
Authors: Terrazas Abel Rogelio 
Published: February 2019

El siguiente trabajo hace un análisis de los personajes del coloquio conventual novohispano Coloquio religiosísimo dedicado al dulce Nombre de Jesús, así como de algunos elementos espectaculares importantes para su representación y de algunas condiciones y posibilidades artísticas del teatro de monjas desde la perspectiva del concepto de la “ciudad letrada”, de Ángel Rama. El coloquio conventual posee rasgos dramáticos que demuestran el conocimiento de la tradición teatral desarrollada en el interior de los conventos y las exigencias ideológicas canalizadas de manera sistemática. El análisis ha permitido observar cómo, desde la parodia, la burla y el humor, el teatro novohispano generó espectáculos ingeniosos en espacios sumamente regulados, tales como los conventos de carmelitas descalzas.Recibido: 27 de abril de 2018Aceptado: 15 de junio de 2018
Pelatihan Dan Pendampingan Kelompok Pemuda Dalam Peningkatan Pelayanan Dan Pengelolaan Kawasan Obyek Wisata Candi Cetho
Authors: Windrawanto Yustinus , Irawan Sapto , Setyorini Setyorini 
Published: February 2019

Sumber daya manusia merupakan salah satu faktor penting dalam berbagai bidang, termasuk dalam hal pengelolaan dan pengembangan obyek wisata. Peningkatan sumber daya manusia yang ada didaerah kawasan wisata dapat meningkatkan kemampuan dalam pengelolaan dan pengembangan potensi yang ada didaerah tersebut. Peningkatan sumber daya manusia dapat dilakukan melalui berbagai kegiatan dan program. Oleh karena itu melalui program pengabdian kepada masyarakat ini, melakukan pelatihan dan dan pendampingan kepada dua kelompok pemuda PERADAH dan pengelola bumi perkemahan dikawasan candi Cetho. Tujuan kegiatan ini yaitu untuk meningkatkan kemampuan dan keterampilan para pemuda dalam pelayanan kepada para pengunjung kawasan candi Cetho dan meningkatan pengelolaan dan pengembangan bumi perkemahan. Hasil kegiatan peningkatan sumber daya manusia dilakukan melalui pelatihan dan pendampingan kepada dua kelompok pemuda PERADAH dan pengelola bumi perkemahan dengan fokus dan pokok materi tentang: Pelatihan komunikasi antar pribadi, Pelatihan manajemen kelompok, dan Pendampingan kelompok, bagi kelompok PERADAH. Sedangkan kepada kelompok pengelola bumi perkemahan pelatihan dan pendampingan tentang: Pelatihan teknik memfasilitasi, Workshop pengembangan layanan bumi perkemahan, Pelatihan manajemen kelompok, dan Pendampingan kelompok.
Total phenolic and flavonoid contents and antioxidant capacity of home-made Isabella grape (Vitis labrusca L.) vinegar
Authors: AYDIN Sinem , DEMİR GÖKIŞIK Cavidan 
Published: February 2019

Vitis
vinifera is
commonly consumed and utilized to produce juice, which has health benefits. The
purpose of the current study is to determine antioxidant activity of the
vinegar obtained from V. vinifera. While total phenolic content was
found as 160.23 ± 0.007 µg GAE/ml, total flavonoid content was determined as
298 ± 0.069 µg CE/ml. Moreover, total antioxidant capacity was detected
as 113.12 ± 0.011 µg AAE/ml. CUPRAC activity and DPPH
radical scavenging activity of the vinegar was higher than standards (BHT for
CUPRAC activity, BHT and Rutin for DPPH activity). The grape vinegar exhibited lower ABTS radical
scavenging activity than standards (BHT and Rutin). Both ABTS and DPPH radical
scavenging activity of the grape vinegar and standards (BHT and Rutin) increased
with the increasing concentration. ABTS activity of the vinegar ranged between 27.47%
and 63.72%. This study reveals that grape vinegar possess significant
antioxidant properties and may be an alternative to synthetic antioxidant
agents.
Analisis Pengaruh Rasio Keuangan terhadap Return Saham PT. Adhi Karya (Persero) Tbk.
Authors: Fuad Muhammad , Mughni Novia Al 
Published: February 2019

Penelitian ini menganalisis pengaruh dari rasio-rasio keuangan yang meliputi likuiditas, solvabilitas dan profitabilitas, terhadap return saham PT. Adhi Karya (Persero) Tbk. Rasio likuiditas, solvabilitas dan profitabilitas, masing-masing direpresentasi oleh current ratio, debt to equity ratio dan return on investment. Data sekunder berupa laporan keuangan selama periode 2008-2016, dan di analisis menggunakan metode regresi linier berganda. Hasil-hasil yang diperoleh menyatakan bahwa ketiga rasio keuangan memiliki pengaruh positif dan signifikan terhadap return saham dari PT. Adhi Karya (Persero) Tbk. Dengan demikian, baik hipotesis pertama maupun kedua dapat diterima kebenarannya. Pengaruh terbesar dimiliki oleh rasio profitabilitas. Koefisien determinasi menunjukkan ketiga rasio keuangan yang dianalisis memiliki kemampuan relatif rendah dalam menjelaskan perubahan dari return saham obyek penelitian.
Türkiye’de, Sosyal Bilgiler Eğitimine İlişkin Alan Eğitimcilerinin Sorunsal Tespitleri
Authors: KOÇOĞLU Erol , EGÜZ Şule 
Published: February 2019

Sosyal Bilgiler eğitimi çalışma
alanı, bireyi toplumsallaştıran, geçmişi
hatırlatarak bugünü yaşamasını ve yarını da kucaklamasını öğreten bir
disiplinler topluluğudur. Hayatın kendisini konu alan bu dersin öğretimi,
insanların topluluk halinde yaşamaya başlamasından günümüze kadar süre
gelmiştir. Giderek küresel bir yapıya bürünen dünyamızda gelecek nesillerin
yetiştirilmesinde Sosyal Bilgiler dersi önemli bir rol oynayacaktır. Yarının
insanını yetiştirmede önemli rol oynayacak olan Sosyal Bilgiler dersinin
öğretilmesi konusunda Cumhuriyetten günümüze kadar çeşitli programlar
uygulanmıştır. Programların bir kısmı yayınlandığı dönemde başarıyla
uygulanmışsa da bazı programların uygulanması konusunda ciddi sorunlarla
karşılaşılmıştır. Bu sorunlar genelde yeterli altyapının oluşmaması, ülkemizin
içinde bulunduğu şartların göz önünde bulundurulmaması ve program içeriğinin
sağlıklı bir şekilde oluşturulmaması olarak sıralanabilir. Sosyal bilgiler
eğitimi alanında yaşanan bu sorunları en az seviyeye indirmek amacıyla
Türkiye’de Sosyal Bilgiler Eğitimi Bilim Dalı Lisans Programı çeşitli
üniversitelerin Eğitim Fakültesi bünyesinde kurulmuş ve öğretmen adayı yetiştirmeye
günümüzde devam etmektedir. Kurulan bu bilim dalı, birçok disiplini içerisinde
barındırması alan uzmanlarının yeterlilik düzeylerinin çeşitlenmesi
gerekliliğini beraberinde getirmiştir. Bu yeterliliklerin istenilen seviyelerde
olmaması yaşanılan birçok sorunun kaynağı olarak gösterilmektedir. Yapılan bu araştırmanın amacı, sosyal
bilgiler eğitimindeki problemlerin değerlendirilmesinde alan uzmanlarının
algılarını belirlemektir. Sosyal bilgiler eğitimi alanında doktora eğitimini
tamamlamış 15 alan eğitimcinin katıldığı bu araştırmada betimsel tarama yöntemi
kullanılmış olup verilerin analizinde Nvivo 11 analiz programı kullanılmıştır.
Araştırmada elde edilen veriler incelendiğinde sosyal bilgiler eğitimi alan
uzmanlarının sosyal bilgiler eğitimi alanına ilişkin ilkokul–ortaokul ve lisans
boyutunda yaşanan problemlerden bazılarına ilişkin benzer bazılarına ilişkin
farklı algılara sahip oldukları gözlemlenmiştir.
Temel Sanat Eğitiminde Buluş Yoluyla Öğretim Yaklaşımının Önemi
Authors: AKENGİN Çağatay , BAŞBUĞ Zuhal 
Published: February 2019

Bu makalede, plastik sanatlar bölümlerinin
temel atölye derslerinden biri olan Temel Sanat Eğitimi dersinde buluş yoluyla
öğretim yaklaşımının önemi üzerinde durulmuştur. Çağın sanat eğitimi
konusundaki genel yaklaşımı ve uygulanan bazı modeller incelenmiştir. Buluş
yoluyla öğretimin temel prensiplerinin Temel Sanat Eğitimi dersiyle kesişme
noktaları, dersin ilke ve elemanlarının öğretiminde sağlayıcı katkılar ve özgün
tasarımlara yansıma biçimleri üzerinde durulmuştur. Ezberci bir yaklaşım yerine
katılımcı yaklaşımı öneren bu modelle birlikte, eğitimcinin rehberliğinde
hazırlanan sanatsal tasarımların niteliği çalışmanın konuları arasında
bulunmaktadır. Öğrencileri araştırmaya yapmaya, keşfe, sorunlara yaratıcı
çözümler bulmaya yönlendiren, merak uyandıran, yaratıcılığa ortam hazırlayan ve
buluşun önünü açan bir yaklaşım olmasından dolayı yöntemin getireceği faydalar büyük
önem taşımaktadır. Temel sanat
eğitiminin, sanatsal yaratıcılığa sağlayıcı katkı, bu yöntemle birlikte daha
bilimsel bir biçimde ele alınmış ve öğretim aşamasına ne şekilde yansıdığı
irdelenmiştir.
In-flight Characterization and Calibration of the Juno-ultraviolet Spectrograph (Juno-UVS)
Authors: Hue Vincent , Randall Gladstone G. , Greathouse Thomas K. , Kammer Joshua A. , Davis Michael W. , Bonfond Bertrand , Versteeg Maarten H. , Grodent Denis C. , Gérard Jean-Claude , Bolton Scott J. , Levin Steven M. , Byron Ben D. 
Published: February 2019

Abstract

Juno is the first polar orbiter around Jupiter. Juno possesses a suite of instruments designed to measure the electron and ion populations in the Jupiter magnetosphere, leading to the powerful Jovian aurorae. The Ultraviolet Spectrograph onboard Juno (Juno-UVS) is a photon-counting imaging spectrograph (68–210 nm), designed to observe and characterize Jupiter’s far-ultraviolet aurorae. The instrument borrows heavily from previous Alice and UVS instruments led by Southwest Research Institute (New Horizons and Rosetta Alices, LRO-LAMP), with several major improvements. The pointing flexibility offered by the UVS scan mirror combined with Juno’s spin allows UVS access to half of the sky at any given moment. This paper describes how we leverage this extensive database to track the evolution of Juno-UVS calibration with time throughout the mission. UVS observes 7.2° × 360°-long swaths of the sky for each rotation of the spacecraft (nominally 2 rpm). This paper describes how the very substantial amount of stellar spectra has been used to monitor the health of the instrument over the mission. As of PJ14 (2018 July 16), more than 8700 spectra of O, A, and B stars have been extracted in the V-magnitude range of ∼0–7, and more than 99% of the sky was mapped. Selected stars among this list were used to calibrate the UVS bandpass, using observations from the International Ultraviolet Explorer and the Hubble Space Telescope. The retrieved effective area of the instrument is 0.30 ± 0.03 cm2 at 125 nm, 0.15 ± 0.02 cm2 at 140 nm, and 0.05 ± 0.01 cm2 at 160 nm.
Rotational Light Curves of Jupiter from Ultraviolet to Mid-infrared and Implications for Brown Dwarfs and Exoplanets
Authors: Ge 葛 Huazhi 華志 , Zhang Xi , Fletcher Leigh N. , Orton Glenn S. , Sinclair James , Fernandes Josh , Momary Tom , Kasaba Yasumasa , Sato Takao M. , Fujiyoshi Takuya 
Published: February 2019

Abstract
Rotational modulations are observed on brown dwarfs and directly imaged exoplanets, but the underlying mechanism is not well understood. Here we analyze Jupiter’s rotational light curves at 12 wavelengths from the ultraviolet (UV) to the mid-infrared (mid-IR). The peak-to-peak amplitudes of Jupiter’s light curves range from subpercent to 4% at most wavelengths, but the amplitude exceeds 20% at 5 μm, a wavelength sensing Jupiter’s deep troposphere. Jupiter’s rotational modulations are primarily caused by discrete patterns in the cloudless belts instead of the cloudy zones. The light-curve amplitude is controlled by the sizes and brightness contrasts of the Great Red Spot (GRS), expansions of the North Equatorial Belt (NEB), patchy clouds in the North Temperate Belt (NTB), and a train of hot spots in the NEB. In reflection, the contrast is controlled by upper tropospheric and stratospheric hazes, clouds, and chromophores in the clouds. In thermal emission, the small rotational variability is caused by the spatial distribution of temperature and opacities of gas and aerosols; the large variation is caused by the NH3 cloud holes and thin-thick clouds. The methane-band light curves exhibit opposite-shape behavior compared with the UV and visible wavelengths, caused by a wavelength-dependent brightness change of the GRS. Light-curve evolution is induced by periodic events in the belts and longitudinal drifting of the GRS and patchy clouds in the NTB. This study suggests several interesting mechanisms related to distributions of temperature, gas, hazes, and clouds for understanding the observed rotational modulations on brown dwarfs and exoplanets.