bluuebunny/crossref_metadata_2025_split huggingface dataset:
Survival of selected lactic acid bacteria isolated from pineapple waste in refrigerated pineapple juices
Authors: Fang Wu Jannette Wen , Uribe Lidieth , WingChing-Jones Rodolfo , Usaga Jessie , Barboza Natalia 
Published: August 2018

ABSTRACTThe aim of this research was to isolate and identify lactic acid bacteria (LAB) from pineapple waste. The survival in refrigerated pineapple juices, of a selected isolate with potential probiotic properties, was also studied. The 16S rRNA andpheSpartial genes were used to identify LAB, multilocus sequence typing (MLST) genes were used in order to separate strains grouping withLactobacillus caseiandL. paracaseiphylogenetically. Tests for survival at pH 2.0, resistance to lysozyme and tolerance to bile salts were used to screen the strains for potential probiotic properties. AL. fermentumisolate was used for the survival study. Three types of pineapple juice made from pulp, a blend of pulp and peel (80:20), and peel extract were inoculated to approximately 106CFU/mL withL. fermentumand stored at 4 °C for up to six weeks. The physicochemical composition of juices, including concentration of fermentable sugars and organic acids, total solids content, soluble solids content, titratable acidity and pH, was determined during the survival study. Two genera and five species were identified. Pineapple juices supported the survival ofL. fermentumduring refrigerated storage but the population of the bacteria decreased over time regardless of the juice type. Juice made from pulp was a more suitable vehicle for the survival of the selected LAB. Some of the juice physicochemical properties, including sugars and organic acids content, pH and titratable acidity, varied significantly (P<0.05) during storage. Further sensory studies are necessary to evaluate consumer acceptance of juices containing the selected isolate.IMPORTANCELactic acid bacteria (LAB), isolated from pineapple waste, were phylogenetically analyzed and characterized in regards to their tolerance to pH 2.0, lysozyme and bile salts; showing their potential as probiotic strains, if health benefits associated to their ingestion are eventually confirmed. Moreover, pineapple juice supported the survival ofLactobacillus fermentum, isolated from the same food matrix, during refrigerated storage at 4 °C. Among the three pineapple juices tested (pulp, pulp + peel and peel),L. fermentumsurvived better in juice made from pulp. However, significant variations were observed overtime in some of the physicochemical properties of the juices including sugars and organic acids content, pH and total titratable acidity.
In silico Repositioning of Approved Drugs Against Schistosoma mansoni Energy Metabolism Targets
Authors: Calixto Nicole Melo , dos Santos Daniela Braz , Bezerra José Clecildo Barreto , Silva Lourival de Almeida 
Published: August 2018

AbstractSchistosomiasis is a neglected parasitosis caused by Schistosoma spp. Praziquantel is used for the chemoprophylaxis and treatment of this disease. Although this monotherapy is effective, the risk of resistance and its low efficiency against immature worms compromises its effectiveness. Therefore, it is necessary to develop new schistosomicide drugs. However, the development of new drugs is a long and expensive process. The repositioning of approved drugs has been proposed as a quick, cheap, and effective alternative to solve this problem. This study employs chemogenomic analysis with use of bioinformatics tools to search, identify, and analyze data on approved drugs with the potential to inhibit Schistosoma mansoni energy metabolism enzymes. The TDR Targets Database, Gene DB, Protein, DrugBank, Therapeutic Targets Database (TTD), Promiscuous, and PubMed databases were used. Fifty-nine target proteins were identified, of which 18 had one or more approved drugs. The results identified 20 potential drugs for schistosomiasis treatment, all approved for use in humans.
Cleaner wrasse pass the mark test. What are the implications for consciousness and self-awareness testing in animals?
Authors: Kohda Masanori , Hotta Takashi , Takeyama Tomohiro , Awata Satoshi , Tanaka Hirokazu , Asai Jun-ya , Jordan L. Alex 
Published: August 2018

AbstractThe ability to perceive and recognise a reflected mirror image as self (mirror self-recognition, MSR) is considered a hallmark of cognition across species. Although MSR has been reported in mammals and birds, it is not known to occur in any other major taxon. A factor potentially limiting the ability to test for MSR is that the established assay for MSR, the mark test, shows an interpretation bias towards animals with the dexterity (or limbs) required to touch a mark. Here, we show that the cleaner wrasse fish, Labroides dimidiatus, passes through all phases of the mark test: (i) social reactions towards the reflection, (ii) repeated idiosyncratic behaviours towards the mirror (contingency testing), and (iii) frequent observation of their reflection. When subsequently provided with a coloured tag, individuals attempt to remove the mark in the presence of a mirror but show no response towards transparent marks, or to coloured marks in the absence of a mirror. This remarkable finding presents a challenge to our interpretation of the mark test – do we accept that these behavioural responses in the mark test, which are taken as evidence of self-recognition in other species, mean that fish are self-aware? Or do we conclude that these behavioural patterns have a basis in a cognitive process other than self-recognition? If the former, what does this mean for our understanding of animal intelligence? If the latter, what does this mean for our application and interpretation of the mark test as a metric for animal cognitive abilities?
Aged-senescent cells contribute to impaired heart regeneration
Authors: Lewis-McDougall Fiona C. , Ruchaya Prashant J. , Domenjo-Vila Eva , Teoh Tze Shin , Prata Larissa , Cottle Beverley J. , Clark James E. , Punjabi Prakash P. , Awad Wael , Torella Daniele , Tchkonia Tamara , Kirkland James L. , Ellison-Hughes Georgina M. 
Published: August 2018

AbstractAging leads to increased cellular senescence and is associated with decreased potency of tissue-specific stem/progenitor cells. Here we have done an extensive analysis of cardiac progenitor cells (CPCs) isolated from human subjects with cardiovascular disease (n=119), aged 32-86 years. In aged subjects (>74 years old) over half of CPCs are senescent (p16INK4A, SA-β-gal, DNA damage γH2AX, telomere length, Senescence-Associated Secretory Phenotype (SASP)), unable to replicate, differentiate, regenerate or restore cardiac function following transplantation into the infarcted heart. SASP factors secreted by senescent CPCs renders otherwise healthy CPCs to senescence. Elimination of senescent CPCs using senolytics abrogates the SASP and its debilitative effectin vitro. Global elimination of senescent cells in aged mice (INK-ATTAC or wildtype mice treated with D+Q senolytics)in vivoactivates resident CPCs (0.23±0.06% vs. 0.01±0.01% vehicle; p<0.05) and increased the number of small, proliferating Ki67-, EdU-positive cardiomyocytes (0.25±0.07% vs. 0.03±0.03% vehicle; p<0.05). Therapeutic approaches that eliminate senescent cells may alleviate cardiac deterioration with aging and rejuvenate the regenerative capacity of the heart.
Efficacy of adaptive reuse for the redevelopment of underutilised historical buildings
Authors: Aigwi Itohan Esther , Egbelakin Temitope , Ingham Jason 
Published: August 2018

Purpose
Most provincial town centres in New Zealand typically feature old and vacant historical buildings, the majority of which possess heritage values. The growing perception that it is cheaper to repurpose vacant historical buildings rather than demolishing and rebuilding them is one of the factors that have made the adaptive reuse approach so popular. However, will this also be the case for provincial town centres in New Zealand? The purpose of this paper is to identify and explore the key factors that could influence the efficacy of adaptive reuse, and check for significant differences in the effect that each perceived factor would have on the adaptive reuse efficacy as a justifiable resilient and sustainable approach towards the regeneration of a major provincial town centre in New Zealand that is currently experiencing inner-city shrinkage.

Design/methodology/approach
A focus group workshop was conducted with 22 stakeholders involved in an existing town centre regeneration agenda for Whanganui. Closed-ended questionnaires were administered to the workshop participants to measure their opinions regarding the efficacy of the adaptive reuse approach for the regeneration of Whanganui’s town centre. The participant mix comprised a combination of structural engineers, quantity surveyors, architects, estate valuers, building owners/developers, legal representatives, heritage representatives and local government council representatives.

Findings
The study reported a high proportion of respondents that strongly agreed to the positive impacts of adaptive reuse with regards to the discussed priority aspects, hence, justifying the efficacy of the approach, towards delivering a vibrant town centre for Whanganui. Also, the Friedman’s analysis suggests that no significant differences existed among all perceived adaptive reuse efficacy criteria by the workshop participants, therefore justifying the approach.

Originality/value
This paper’s originality pertains to the practicality of changing the use of vacant historical buildings in Whanganui, which is one of New Zealand’s major provincial town centres, to renegotiate resilience and sustainable urban regeneration for the area.
Investigating the in-plane flexibility of steel-deck composite floors in steel structures
Authors: Bazarchi Ehsan , Hosseinzadeh Yousef , Panjebashi Aghdam Parinaz 
Published: August 2018

Purpose
It is common practice in structural engineering to assume floor diaphragms infinitely stiff in their own plane. But, most of the code provisions lack clarity and unity in categorising floor diaphragms and discussing their behaviour based on the seismic response of the structures. Besides, although many of these code provisions have presented simple techniques and formulations for determining the level of flexibility in floor diaphragms, the implementation of these techniques on more complex floor systems such as the steel-deck composite floors is still under question. The paper aims to discuss these issues.

Design/methodology/approach
In this study, an equivalent concrete floor is employed as a representative of in-plane diaphragm action of steel-deck composite floor, using simple modelling techniques in SAP2000 and the results are validated by complex structural models developed in ABAQUS. Afterwards, the equivalent floor is inserted to 3, 5 and 7 storey steel structures with 2, 3 and 5 plan aspect ratios in two categories of structures with rigid diaphragms and analogous structures with flexible diaphragms and the responses are compared to each other.

Findings
The results show that the proposed technique is an effective method for evaluating the diaphragm action of steel-deck composite floors. Additionally, it is concluded that, the boundary values of plan aspect ratio equal to 3 and λ coefficient equal to 0.5 in steel-deck composite floors, mentioned in code provisions for categorising diaphragms, are not always conservative and need to be scrutinised.

Originality/value
The proposed methodology provides simple framework for assessing the effects of in-plane flexibility of steel-deck composite on seismic response of steel structures.
Influence of sulfuric and hydrochloric acid on the resistance of geopolymer cement with nano-silica additive for oil well cement application
Authors: Ridha Syahrir , Abd Hamid Afif Izwan , Setiawan Riau Andriana , Shahari Ahmad Radzi 
Published: August 2018

PurposeThe purpose of this paper is to investigate the resistivity of geopolymer cement with nano-silica additive toward acid exposure for oil well cement application.Design/methodology/approachAn experimental study was conducted to assess the acid resistance of fly ash-based geopolymer cement with nano-silica additive at a concentration of 0 and 1 wt.% to understand its effect on the strength and microstructural development. Geopolymer cement of Class C fly ash and API Class G cement were used. The alkaline activator was prepared by mixing the proportion of sodium hydroxide (NaOH) solutions of 8 M and sodium silicate (Na2SiO3) using ratio of 1:2.5 by weight. After casting, the specimens were subjected to elevated curing condition at 3,500 psi and 130°C for 24 h. Durability of cement samples was assessed by immersing them in 15 wt.% of hydrochloric acid and 15 wt.% sulfuric acid for a period of 14 days. Evaluation of its resistance in terms of compressive strength and microstructural behavior were carried out by using ELE ADR 3000 and SEM, respectively.FindingsThe paper shows that geopolymer cement with 1 wt.% addition of nano-silica were highly resistant to sulfuric and hydrochloric acid. The strength increase was contributed by the densification of the microstructure with the addition of nano-silica.Originality/valueThis paper investigates the mechanical property and microstructure behavior of emerging geopolymer cement due to hydrochloric and sulfuric acids exposure. The results provide potential application of fly ash-based geopolymer cement as oil well cementing.
Why do listed companies delist themselves voluntarily?
Authors: Konno Yukiko , Itoh Yuki 
Published: August 2018

PurposeThis study aims to analyse, from a corporate finance and governance perspective, the reasons why managers decide to delist their companies from a stock exchange. On the basis of the five hypotheses of voluntary delisting, this study examines why listed companies delist themselves voluntarily in the construction and real estate sectors.Design/methodology/approachBy using actual data to examine contractors and real estate companies listed on the Tokyo Stock Exchange between 2004 and 2014, this study analyses whether these companies delist themselves voluntarily. The pooled binary logit model is used as the statistical method.FindingsIn both the construction and real estate sectors, the concentration of shareholders has a significantly positive effect on voluntary delisting, thus supporting the transfer of wealth effect hypothesis. In construction, market capitalisation has a significantly negative effect on voluntary delisting, thus supporting the maintenance cost reduction hypothesis. In the real estate sector, the ratio of market capitalisation to total assets has a significantly negative effect on voluntary delisting, thus supporting the undervalue elimination hypothesis.Originality/valueBy comparing the construction and real estate sectors, this study reveals both unique and common reasons for voluntary delisting in each sector. It also offers valuable insights to managers, regulators setting standards in securities markets and investors.
Infrastructure financing and economic growth in India: an empirical investigation
Authors: Chotia Varun , Rao N.V.M. 
Published: August 2018

PurposeThis paper aims to suggest the preferred mode of financing for major sub-sectors of infrastructure: roads, seaports, telecommunication and energy by examining which mode of infrastructure financing – public, private or public–private partnership (PPP) – has the maximum positive impact on the overall GDP of India. The same exercise was carried out for the overall infrastructure sector by integrating data from all the four sub-sectors.Design/methodology/approachThe structural vector autoregressive approach was used with the period of analysis taken from 1995 to 2014. The stationary properties of the variables were checked by the Phillips–Perron unit root.FindingsThe PPP mode of financing was found to make the maximum positive impact on the GDP of India. Considering the four sub-sectors individually, it was concluded that the private mode of financing in roads, energy and telecom sectors has the maximum positive impact on the GDP, while the PPP gives optimal benefit to the seaports sector.Practical implicationsResults will aid the Indian Government and policymakers to efficiently design and develop their economic policies accordingly.Originality/valueThe study is novel in a sense that it helps to address the lack of research into the area of infrastructure financing in India.
Female accounting students and their academic performance: evidence from Kuwait
Authors: Alanzi Khalid A. 
Published: August 2018

Purpose
This study aims to compare the academic performance of female accounting students with their male counterparts and to assess the impact and association between gender and the academic performance of accounting students graduating from the College of Business Studies (CBS) in Kuwait.

Design/methodology/approach
The sample consisted of 141 accounting students, who graduated during 2015 from CBS. Independent samples test, correlation and linear least squares regression analyses tested the hypotheses.

Findings
The results indicate that there was a statistically significant association between gender and accounting students’ performance, which explained the superiority of the performance of the female students’ group over the performance of the male students’ group and explained the significant impact of gender on accounting students’ performance, with and without controls for other factors.

Practical implications
The findings have practical implications for how the administration of CBS and similar educational institutions should take action. The findings suggest that the administration of CBS should adopt policies that impose and encourage the acceptance of more female accounting students, as they perform well in accounting and their academic performance is better than their male counterparts.

Originality/value
The study makes significant contributions to the existing knowledge in the area of students’ performance by empirically supporting the theoretical expectation of the impact of gender on accounting students’ performance. It provides a foundation for future comparative studies, potentially leading to the harmonization of international accounting education. It also addresses some of the shortfalls in the existing regional accounting education literature resulting from the scarcity of prior studies, where little has been published.
The influence of ethical leadership on academic employees’ organizational citizenship behavior and turnover intention
Authors: Shareef Raad Abdulkareem , Atan Tarik 
Published: August 2018

PurposeThe purpose of this paper is to examine the effect of ethical leadership on followers’ organizational citizenship behavior (OCB) and turnover intention and to examine the mediating role of intrinsic motivation in the relationships.Design/methodology/approachThe study employed a quantitative research method with a sample of 351 supervisor–subordinate dyads in three large public universities in the Kurdistan Region of Iraq. The statistical analysis was conducted using Statistical Package for Social Science software, through multiple regression analyses to test the research hypotheses.FindingsThe results indicated that ethical leadership positively related to OCB and negatively related to turnover intentions. The results also showed that intrinsic motivation fully mediates the relationship between ethical leadership, OCB, and turnover intentions.Originality/valueThis study recognized the gap in the literature, and it contributes to the body of knowledge through an examination of the mediating role of intrinsic motivation between ethical leadership, OCB and turnover intention, relying on the cognitive evaluation theory.
Working
Fluid Selection and Technoeconomic Optimization of a Turbocompression Cooling
System
Authors: Young Derek , Gibson Spencer
C. , Bandhauer Todd
M. 
Published: August 2018

Abstract
Low grade waste heat recovery presents an opportunity to utilize typically wasted energy to reduce overall energy consumption and improve system efficiencies. In this work, the technoeconomic performance of a turbocompression cooling system (TCCS) driven by low grade waste heat in the engine coolant of a large marine diesel generator set is investigated. Five different working fluids were examined to better understand the effects of fluid characteristics on system performance: R134a, R245fa, R1234ze(E), R152a, and R600a. A coupled thermodynamic, heat exchanger, and economic simulation was developed to calculate the simple payback period of the waste heat recovery system, which was minimized using a search and find optimization routine with heat exchanger effectiveness as the optimization parameter. A sensitivity study was performed to understand which heat exchanger effectiveness had the largest impact on payback period. Of the five working fluids examined, a TCCS with R152a as the working fluid had the lowest payback period of 1.46 years with an initial investment of $181,846. The R152a system was most sensitive to the two-phase region of the power cycle condenser. The R1234ze(E) system provided the largest return on investment over a ten year lifetime of $1,399,666.
Comparison of the ‘11+ Kids’ injury prevention programme and a regular warmup in children’s football (soccer): a cost effectiveness analysis
Authors: Rössler Roland , Verhagen Evert , Rommers Nikki , Dvorak Jiri , Junge Astrid , Lichtenstein Eric , Donath Lars , Faude Oliver 
Published: August 2018

ObjectiveTo evaluate a potential reduction in injury related healthcare costs when using the ‘11+ Kids’ injury prevention programme compared with a usual warmup in children’s football.MethodsThis cost effectiveness analysis was based on data collected in a cluster randomised controlled trial over one season from football teams (under-9 to under-13 age groups) in Switzerland. The intervention group (INT) replaced their usual warmup with ‘11+ Kids’, while the control group (CON) warmed up as usual. Injuries, healthcare resource use and football exposure (in hours) were collected prospectively. We calculated the mean injury related costs in Swiss Francs (CHF) per 1000 hours of football. We calculated the cost effectiveness (the direct net healthcare costs divided by the net health effects of the ‘11+ Kids’ intervention) based on the actual data in our study (trial based) and for a countrywide implementation scenario (model based).ResultsCosts per 1000 hours of exposure were CHF228.34 (95% CI 137.45, 335.77) in the INT group and CHF469.00 (95% CI 273.30, 691.11) in the CON group. The cost difference per 1000 hours of exposure was CHF−240.66 (95%CI −406.89, −74.32). A countrywide implementation would reduce healthcare costs in Switzerland by CHF1.48 million per year. 1002 players with a mean age of 10.9 (SD 1.2) years participated. During 76 373 hours of football, 99 injuries occurred.ConclusionThe ‘11+ Kids’ programme reduced the healthcare costs by 51% and was dominant (ie, the INT group had lower costs and a lower injury risk) compared with a usual warmup. This provides a compelling case for widespread implementation.