bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of interfacial micromotions on vitality and differentiation of human osteoblasts
Authors: Ziebart J. , Fan S. , Schulze C. , Kämmerer P. W. , Bader R. , Jonitz-Heincke A. 
Published: February 2018

Objectives Enhanced micromotions between the implant and surrounding bone can impair osseointegration, resulting in fibrous encapsulation and aseptic loosening of the implant. Since the effect of micromotions on human bone cells is sparsely investigated, an in vitro system, which allows application of micromotions on bone cells and subsequent investigation of bone cell activity, was developed. Methods Micromotions ranging from 25 µm to 100 µm were applied as sine or triangle signal with 1 Hz frequency to human osteoblasts seeded on collagen scaffolds. Micromotions were applied for six hours per day over three days. During the micromotions, a static pressure of 527 Pa was exerted on the cells by Ti6Al4V cylinders. Osteoblasts loaded with Ti6Al4V cylinders and unloaded osteoblasts without micromotions served as controls. Subsequently, cell viability, expression of the osteogenic markers collagen type I, alkaline phosphatase, and osteocalcin, as well as gene expression of osteoprotegerin, receptor activator of NF-κB ligand, matrix metalloproteinase-1, and tissue inhibitor of metalloproteinase-1, were investigated. Results Live and dead cell numbers were higher after 25 µm sine and 50 µm triangle micromotions compared with loaded controls. Collagen type I synthesis was downregulated in respective samples. The metabolic activity and osteocalcin expression level were higher in samples treated with 25 µm micromotions compared with the loaded controls. Furthermore, static loading and micromotions decreased the osteoprotegerin/receptor activator of NF-κB ligand ratio. Conclusion Our system enables investigation of the behaviour of bone cells at the bone-implant interface under shear stress induced by micromotions. We could demonstrate that micromotions applied under static pressure conditions have a significant impact on the activity of osteoblasts seeded on collagen scaffolds. In future studies, higher mechanical stress will be applied and different implant surface structures will be considered. Cite this article: J. Ziebart, S. Fan, C. Schulze, P. W. Kämmerer, R. Bader, A. Jonitz-Heincke. Effects of interfacial micromotions on vitality and differentiation of human osteoblasts. Bone Joint Res 2018;7:187–195. DOI: 10.1302/2046-3758.72.BJR-2017-0228.R1.
Effects of a phosphocitrate analogue on osteophyte, subchondral bone advance, and bone marrow lesions in Hartley guinea pigs
Authors: Sun Y. , Kiraly A. J. , Sun A. R. , Cox M. , Mauerhan D. R. , Hanley E. N. 
Published: February 2018

Objectives The objectives of this study were: 1) to examine osteophyte formation, subchondral bone advance, and bone marrow lesions (BMLs) in osteoarthritis (OA)-prone Hartley guinea pigs; and 2) to assess the disease-modifying activity of an orally administered phosphocitrate ‘analogue’, Carolinas Molecule-01 (CM-01). Methods Young Hartley guinea pigs were divided into two groups. The first group (n = 12) had drinking water and the second group (n = 9) had drinking water containing CM-01. Three guinea pigs in each group were euthanized at age six, 12, and 18 months, respectively. Three guinea pigs in the first group were euthanized aged three months as baseline control. Radiological, histological, and immunochemical examinations were performed to assess cartilage degeneration, osteophyte formation, subchondral bone advance, BMLs, and the levels of matrix metalloproteinse-13 (MMP13) protein expression in the knee joints of hind limbs. Results In addition to cartilage degeneration, osteophytes, subchondral bone advance, and BMLs increased with age. Subchondral bone advance was observed as early as six months, whereas BMLs and osteophytes were both observed mainly at 12 and 18 months. Fibrotic BMLs were found mostly underneath the degenerated cartilage on the medial side. In contrast, necrotic BMLs were found almost exclusively in the interspinous region. Orally administered CM-01 decreased all of these pathological changes and reduced the levels of MMP13 expression. Conclusion Subchondral bone may play a role in cartilage degeneration. Subchondral bone changes are early events; formation of osteophytes and BMLs are later events in the OA disease process. Carolinas Molecule-01 is a promising small molecule candidate to be tested as an oral disease-modifying drug for human OA therapy. Cite this article: Y. Sun, A. J. Kiraly, A. R. Sun, M. Cox, D. R. Mauerhan, E. N. Hanley Jr. Effects of a phosphocitrate analogue on osteophyte, subchondral bone advance, and bone marrow lesions in Hartley guinea pigs. Bone Joint Res 2018;7:157–165. DOI:10.1302/2046-3758.72.BJR-2017-0253.
Physico-chemical quality of waters of tubular wells located in the interior of the State of Rio Grande do Norte
Authors: Dantas Gerbeson Carlos Batista , Farias Henriqueta Monalisa , Oliveira Camila Rafaela Santos de , Silveira Arthuro Munay Dantas da , Barros Sâmea Valensca Alves 
Published: February 2018

Este trabalho tem como objetivo realizar a caracterização físico-química da água de dois poços tubulares, no período de três meses, localizados na zona rural do município de Parelhas, Estado do Rio Grande do Norte, e posteriormente, analisar a viabilidade de utilização da água bruta para consumo humano. Em relação às analises físico-químicas, foram determinados 15 parâmetros, tanto para a amostra A, como para a amostra B, a fim de caracterizá-las: pH, condutividade elétrica, temperatura na fonte, bicarbonato (HCO3-), cloreto (Cl-), dureza total (CaCO3), dureza (Ca2+), dureza (Mg2+), alcalinidade, sólidos totais dissolvidos, oxigênio dissolvido, nitrogênio amoniacal, nitrito (NO2-), nitrato (NO3-) e ferro. De acordo com os ensaios, as águas sob análise, apresentaram discordâncias em relação a Portaria de Potabilidade 2914/2011 nos seguintes parâmetros: Alcalinidade, sólidos totais dissolvidos, nitratos, nitritos e ferro. Somando-se a isso, as águas foram classificadas como duras (amostra B) e muito duras (amostra A), apresentaram condutividade extremamente elevada, superior a 590 μS.cm-1 e baixo teor de oxigênio dissolvido. Por fim, este trabalho conclui, a partir dos resultados dos parâmetros físico-químicos da amostra A e amostra B, que as água brutas dos poços estão inapropriadas ao consumo humano.
Reasons of Preservice Teachers Attending the Pedagogical Formation Certificate Program for Choosing Teaching as a Profession
Authors: DENİZ Sabahattin , DOĞAN Uğur , ŞAHİN Nurettin 
Published: February 2018

DOI:	Due to social, economic and cultural conditions, preservice teachers’ reasons for choosing the teaching profession differ from country to country. The purpose of the current study is to determine the factors affecting the choices of prospective teachers in the process of preferring the profession of teaching. The participants of the study were 230 voluntary preservice teachers randomly selected from among the students attending the pedagogical formation certificate program in the academic year of 2016-2017. Factors Influencing Teaching Choice scale (FIT-Choice scale) developed by Watt and Richardson (2007) and then adapted in the Turkish context by Kılınç, Watt and Richardson (2012) was used in the research. The correlation between the pedagogical formation students’ motivation and level of perception in relation to their preferring the profession of teaching was investigated by using Structural Equation Modeling (SEM). It is seen that the obtained model has good fit indices. According to SEM, as a reason for choosing teaching as their profession, while the pedagogical formation students put greater emphasis on desire to work with children/adolescents and secure nature of the profession, they put less emphasis on transferability of teaching (job transferability) and use of the time allocated to the family. Moreover, their satisfaction with their decision to be a teacher seems to be great and it is observed that they have not been affected by the opinions of people around them.
PERUSAHAAN DAN KONSERVASI KEANEKARAGAMAN HAYATI LAUT: THE RIGHT TO TOURISM vs SUSTAINABLE TOURISM
Authors: Dharmawan Ni Ketut Supasti , Sarjana Made , Samshitawrati Putu Aras 
Published: February 2018

Keanekaragam hayati laut dikembangkan sebagai salah satu produk dalam kegiatan kepariwisataan serta akses the right to tourism bagi wisatawan. Namun, pemenuhan hak tersebut jangan sampai mengorbankan sustainable tourism bagi generasi mendatang, khususnya akses lingkungan sehat mata rantai ekosistem keanekaragaman hayati biota laut. Oleh karenanya, penting mengkaji tanggungjawab perusahaan dalam usaha perlindungan dan konservasi. Metode penelitian hukum normatif digunakan untuk mengkaji Convention on Biological Diversity, UNWTO, UDHR, the GPs for Business and Human Rights, U.U. No. 5 Tahun 1990, U.U. No. 32 Tahun 2009, maupun U.U. No. 10 Tahun 2009. Perusahaan bersama dengan stakeholders lainnya bertanggungjawab mewujudkan perlindungan dan konservasi terhadap keanekaragaman biota laut. Model Action Plans on Business and Human Rights relevan untuk meningkatkan tanggung jawab perusahaan dalam perlindungan dan konservasi keanekaragaman hayati laut.
ROYALTI HAK CIPTA SEBAGAI OBYEK JAMINAN FIDUSIA
Authors: Santoso Djoko Hadi , Sujatmiko Agung - 
Published: February 2018

Royalti Hak Cipta sebagai hak tagihan dari perjanjian Lisensi yang merupakan imbalan atas pemanfaatan hak ekonomi suatu ciptaan yang biasanya dibayarkan sebagai kompensasi dari pemberian ijin atau lisensi dari pemilik atau pemegang hak cipta kepada pihak lain. Royalti merupakan aset tidak berwujud yang berisi klaim atas tagihan uang di masa datang dapat diasumsikan sebagai aset keuangan. Aset adalah hal yang bernilai ekonomis yang dimiliki oleh penulis buku berupa uang dari prosentase harga jual buku dikalikan jumlah buku yang terjual. Semakin laku bukunya, akan semakin besar juga prosentase penerimaan uang oleh penulis buku, demikian juga sebaliknya. Sehingga jelas bahwa Royalti memiliki nilai ekonomis tersebut, sehingga termasuk karakteristik suatu benda yang dapat digunakan sebagai obyek jaminan utang yaitu apabila benda tersebut mempunyai nilai ekonomis dan dapat dipindah tangankan dalam artian suatu saat apabila debitor tidak dapat melunasi utangnya, benda tersebut dapat dijual oleh bank.Perjanjian yang dapat dibuat untuk pelaksanaan Royalti Hak Cipta sebagai benda tidak berwujud dan penjelasan mengenai eksekusinya yang paling tepat dengan Undang – Undang Nomor 42 tahun 1999 tentang Jaminan Fidusia.
KEKUASAAN KEHAKIMAN DALAM PERSPEKTIF NEGARA HUKUM DI INDONESIA
Authors: Busthami Dachran 
Published: February 2018

Karya ilmiah ini membahas negara hukum sebagai pilihan terbaik dalam menata kehidupan bernegara yang berdasarkan demokrasi dengan suatu konstitusi atau UUD yang mengatur hubungan antar negara dan rakyat, hak-hak asasi warga negara dan pembatasan kekuasaan penguasa serta jaminan keadilan dan persamaan di hadapan hukum serta kesejahtraan bagi masyarakat. Metode penelitian karya ilmiah ini adalah penelitian hukum yuridis normatif. Analisis data penelitian yuridis normatif adalah kegiatan pengolahan data dan sistematisasi terhadap bahan-bahan hukum tertulis. Hasil penelitian menunjukkan bahwa hanya pada konsep bernegara hukum, kekuasaan kehakiman dapat mandiri dalam menjalankan fungsi judisialnya, sehingga memungkinlan pelaksana kekuasaan kehakiman berlaku fair dalam memeriksa, mengadili dan memutus suatu perkara berdasarkan hukum dan keadilan.
OUTSOURCING JASA KEBERSIHAN DI INSTANSI PEMERINTAH
Authors: Sujoko Ajik 
Published: February 2018

Penggunaan alih daya jasa kebersihan oleh intansi pemerintah merupakan pilihan. Regulasi outsourcing diatur dalam UU No. 13 Tahun 2003 tentang Ketenagakerjaan yang biasa dilakukan oleh perusahaan. Salah satu bentuk perusahaan menurut ketentuan ketenagakerjaan adalah usaha yang berbadan hukum. Instansi pemerintah belum dapat disebut sebagai perusahaan. Jadi, penggunaan outsourcing oleh instansi pemerintah belum ada peraturan perundang-undangan sebagai dasar hukum. Kendati demikian, instansi pemerintah memiliki kewenangan menggunakan outsourcing. Instansi pemerintah yang menggunakan outsourcing, harus tunduk peraturan ketenagakerjaan. Memilih perusahaan outsourcing di instansi pemerintah, mengikuti ketentuan Perpres No. 54 Tahun 2010 tentang Pengadaan Barang/Jasa Pemerintah dan perubahannya.
An Apparatus for Testing Static Fatigue at Sand Grain Contacts
Authors: Wang Zhijie , Michalowski Radoslaw L. 
Published: February 2018

Abstract
Often referred to as aging, the time-dependent evolution of silica sand properties is particularly distinct after sand disturbance. A likely cause of this behavior is the process of time-delayed fracturing of microscopic features at grain surfaces in contact. This process is denoted as static fatigue or stress corrosion microcracking. An apparatus was constructed to test time-dependent behavior of contacts subjected to sustained loads. The device can measure displacements with a resolution of about 100 nm. The focus of the paper is on the device constructed and not on the process of static fatigue. The details of apparatus construction are presented in the paper, and challenges associated with measuring grain deflection owing to static fatigue at the contacts are discussed. The measurements are sensitive to changes in temperature and humidity and are affected by external vibration excitations. Example results are illustrated, the sources of possible measurement errors are debated, and the challenges of testing are discussed.
Implementation of PV System Integrated DSTATCOM with Modified UVT Control Scheme for Harmonic and Neutral Current Elimination
Authors: Govindasamy P. , Anita R. 
Published: February 2018

Abstract
The interconnection of renewable energy sources into the utility grid gives lot of issues. The important issues faced by the systems are synchronized with the utility grid, power quality, and others. The distribution static compensator (DSTATCOM) is the efficient custom power device that can resolve the power quality problems in the distribution system and interconnect the Photovoltaic (PV) system into the utility grid. The Second Order Generalized Integrator (SOGI) Phase Locked Loop (PLL)–based Unit Vector Template (UVT) control scheme is employed for extraction of reference current to generate gating signals of DSTATCOM. The proposed control algorithm is employed for compensation of current harmonics, reactive power, and voltage interruption. The dc link storage capacitor of the DSTATCOM is utilized to interconnect the PV system into the utility grid, and it is controlled by the UVT-based controller. The PV-supported DSTATCOM provides uninterrupted active and reactive power compensation when disturbances occur in the distribution system. The simulation and experimental results confirm that the proposed DSTATCOM results in purely sinusoidal grid currents with the Total Harmonic Distortion level about 1.28 %, which enhances the power quality of the interconnected PV system.
Regulation of Glutamate Signaling in the Sensorimotor Circuit by CASY-1A/Calsyntenin in Caenorhabditis elegans
Authors: Thapliyal Shruti , Ravindranath Shruthi , Babu Kavita 
Published: February 2018

Abstract
Locomotion is one of the most prominent behaviors in the nematode Caenorhabditis elegans. Neuronal circuits that ultimately produce coordinated dorso-ventral sinusoidal bends mediate this behavior. Synchronized locomotion requires an intricate balance between excitation and inhibition at the neuromuscular junctions (NMJ), the complex cellular and molecular mechanisms of which are not fully understood. Here, we describe the role of a cell adhesion molecule CASY-1, which functions to maintain this balance at the NMJ. In this study, we dissect out mechanisms by which the longer CASY-1A isoform could be affecting the excitatory cholinergic signaling at the NMJ by modulating the activity of sensory neurons. Mutants in casy-1 appear to have hyperactive sensory neurons, resulting in accelerated locomotion and motor circuit activity. These sensory neurons mediate increased motor activity via enhanced glutamate release. Using genetic, pharmacological, and optogenetic manipulations, we establish that CASY-1A is required to monitor the activity of these neurons. Our study illustrates a novel neuromodulatory role of CASY-1-mediated signaling in regulating the excitation-inhibition balance of the motor circuit.
The Challenge of Implementing Green ICT in Computer Colleges: Improving Initiative and Awareness
Authors: Purwaningsih Mardiana 
Published: February 2018

Implementation of Green ICT awareness for computer college in Indonesia already initiated by Association of Computer College in 2010, to realize the Green Campus. Appeared several challenges facing the college in raising awareness in applying the activity in college. This initiation should be supported by formal policy by the leadership, to conform with the purpose of the implementation of Green ICT. This policy is continuously disseminated, Green ICT practices performed consistently, as well as in the medium or long-term need to be measured by a variety of methods of measurement. In order for the implementation of Green ICT can efficiently, there needs to be coordination between the IT Division and the person in charge of the computer laboratory which is separate from the part of IT management. So that information about IT masterplan includes laboratory can be arranged properly, so that it can be monitored clearly. This coordination will also help the college in calculating the energy consumption of electricity used by IT equipment, both of which focused on the IT Division and in the laboratory.
Effect of Thermocycling on Color Stability of Acrylic Resin Materials Immersed in Denture Cleansers
Authors: Abou-Obaid Ala'a Ibrahim 
Published: February 2018

Objective: To evaluate the effect of thermocycling on the color stability of heat and self-cure resins after immersion in denture cleansers.
Material and methods: Forty-eight disks of heat and self-cure resins were fabricated. The specimens of each material were divided into 4 subgroups (n = 12) and immersed in different denture cleansers (Distilled water {control}, Corega, StainAway Plus and Polident) daily for 1 week and first color measurements (T1) were recorded (before thermocycing). The specimens were then subjected to 5000 cycles of thermocycling and the second color measurements (T2) were recorded (after thermocycling).
Results: A significant increase of color change was noticed in self-cure compared to heat-cure resins after thermocycling (p=0.001). The color change in heat-cure resins immersed in different solutions was insignificant (p>0.05). Whereas, there was significant color changes in self-cure resins among denture cleansers (p<0.05). The mean difference of color change was greater in self-cure resins immersed in Corega (3.93 ± 2.71) and Polident (3.55 ± 2.06) compared to the control group (0.15 ± 1.66) and lower in specimens immersed in Stain Away Plus (1.36 ± 1.60) compared to Corega. There was a significant decrease in the mean of color change after thermocycling in heat-cure resins immersed in distelled water and Stain Away Plus (p<0.05) and in self-cure resins immersed in Corega, Stain Away Plus and Polident compared to color change before thermocycling (p<0.05).
Conclusion: Aging process resulted in a significant color change in self-cure compared to heat-cure resins and the value of color difference was varied according to the denture cleanser used.
Effects of the Aqueous Extract of Mimosa Pudica on Experimentally-Induced Prostatic Hyperplasia
Authors: B.E Arayombo , O. S. Adewole , S. K Ojo . , S.T Adelodun , A. K. Adefule , R. A. Bejide , K. A. Salako , I. O. Olabanji , A.O. Ojewole J. 
Published: February 2018

Benign prostatic hyperplasia, a non-cancerous condition of unknown etiology, is the most common prostatic disease in men globally. The present study investigated the possible ameliorative effects of aqueous extracts of Mimosa pudica on experimentally-induced prostatic hyperplasia in Wistar rats.
Twenty adult, male Wistar rats weighing 120-180 g were randomly divided into four groups (A, B, C, D) of five animals each. Group A, normal control, was given corn oil only; Group B rats were hormone-treated. Groups C and D rats were hormone and extract treated, and received continuous doses of 300 μg and 80 μg of testosterone and estradiol, respectively, on alternate days for three weeks subcutaneously in the inguinal region. The extract-treated rats received an additional 400 mg/kg b. w and 800 mg/kg b. w. of M. pudica orally for another four weeks. Immediately after induction of benign prostatic hypertrophy, some animals were randomly selected and sacrificed for gross inspection of prostate enlargement, prostate specific antigen analysis (PSA) and sperm count evaluation. These procedures were repeated again after four weeks of extract treatment. The prostates were excised and processed routinely for paraffin embedding and stained with hematoxylin and eosin (H&E).
Results obtained showed significant (P<0.05) reduction in PSA levels, increase in sperm count and also a reversal of histological hyperplastic changes.
Customer Loyalty Creation Based On Customer and Trust Satisfaction from Quality of Service in Pt. Pharos Indonesia Branch Denpasar
Authors: Trisna Utami Ni Ketut , Sujana I Wayan , Suardhika I Nengah 
Published: February 2018

This study aims to test and analyze service quality, customer satisfaction, trust and customer loyalty. This research was conducted at PT. Pharos Indonesia Denpasar Branch with research population is outlet that make purchasing, sample used 100 units with purposive sampling method. All data obtained from questionnaires are suitable for use, then analyzed using structural equation model based on variance analysis known as Partial Least Square (PLS).
The results showed that the better the quality of service provided to customers, it will have a better impact on improving customer satisfaction, the better the quality of services provided to customers, it will have an impact on increasing trust customers, the more satisfied customers will have an impact on the increase of customer loyalty, the higher the trust the customer will have an impact on increasing customer loyalty, the more satisfied customers will have an impact on increasing trust customers and the better quality of services provided to customers will have an impact on increased customer loyalty.
The implication of this research is that service quality can be improved by considering reliability, customer satisfaction can be improved by paying attention to customer satisfaction to the whole product. Trust can be improved by taking into account competence and customer loyalty can be improved by paying attention to make purchases regularly.
The growing importance of local pumpkin seed oil production in Slovenia
Authors: Golija Maja Godina 
Published: February 2018

Food represents a significant segment of human culture. It is not only a component of the material world and a means to satisfy basic biological needs, but also plays an important role in the economic and social life of the individual and community. Until the middle of the 20th century, the food culture of the Slovene population strongly depended on regional origin. Pumpkin seed oil has a special dietary role and a long tradition among the inhabitants of North- East Slovenia and the cultivation of oil seed pumpkins and production of pumpkin seed oil in the region was already mentioned in 18th century. Slovene pumpkin seed oil is of high-quality and is processed according to the traditional procedure. Since 2005, Styrian-Prekmurje pumpkin seed oil has been protected in the European Union with the Geographical Indication-PGI.
Nowadays, the pumpkin seed oil is also becoming an important expression of regional affiliation and a notable factor of economic development in Prekmurje, Porabje and Štajerska, especially significant for tourism, catering and the production of traditional rural products.