bluuebunny/crossref_metadata_2025_split huggingface dataset:
Functionality Evaluation of Investigational Continuous Subcutaneous Insulin Infusion (CSII) Set vs. Commercially Available Sets—Assessment of 3D Volume and Surface Area over Eight Days
Authors: DIAZ DAVID , DINESEN ALEKSANDR R. , KHALF ABDURIZZAGH , EISLER GABRIELLA J. , LOEUM CHANNY , TORJMAN MARC C. , STRASMA PAUL J. , JOSEPH JEFFREY I. 
Published: June 2018

Over 1 million people with diabetes use insulin pumps and insert a new continuous subcutaneous insulin infusion (CSII) set every 2-3 days for adequate blood glucose control. Insulin absorption from the subcutaneous tissue is slow and varies over time. This can lead to complications such as hypoglycemia and diabetic ketoacidosis. Furthermore, the repeated trauma of insertion contributes to scar tissue formation and may result in infusion site loss. The development of an extended-wear CSII infusion set that can improve the safety and efficacy of CSII therapy would be a major advantage and facilitate proper glycemic control for diabetic patients. A prototype infusion set was developed using a soft polymer material with multiple ports and tested against commercially available single-port infusion sets in ambulatory large swine. Infusion sets were inserted into the subcutaneous tissue every other day for 8 days. A 70µL bolus of insulin and contrast agent was infused through each cannula 5 minutes prior to excision, then specimens were frozen and Micro-CT imaged. The 3D distribution and surface area of contrast agent in contact with adjacent vascular tissue were evaluated. We hypothesized that multiple-ports would increase fluid dispersion, allowing the insulin to reach more functional capillary and lymph vessels. Investigational sets had a statistically significant larger surface area (p=0.005) and volume (p=0.001) of contrast agent spread when compared with commercial infusion sets, potentially supporting our objective of reaching more vessels to achieve consistent insulin absorption over time. Results from this research have guided the design and development of a next-generation infusion set. Clinical translation of this investigational design could result in a reliable insulin delivery system that simplifies diabetes management, improves quality of life, and benefits clinical outcomes.

Disclosure
D. Diaz: None. A.R. Dinesen: None. A. Khalf: None. G.J. Eisler: None. C. Loeum: None. M.C. Torjman: Advisory Panel; Self; Capillary Biomedical, Inc. P.J. Strasma: Board Member; Self; Capillary Biomedical, Inc.. Stock/Shareholder; Self; Capillary Biomedical, Inc.. Employee; Self; Capillary Biomedical, Inc. J.I. Joseph: Stock/Shareholder; Self; Capillary Biomedical, Inc.. Advisory Panel; Self; Capillary Biomedical, Inc.. Research Support; Self; Capillary Biomedical, Inc.. Stock/Shareholder; Spouse/Partner; Capillary Biomedical, Inc.. Advisory Panel; Self; Thermalin Diabetes, LLC.. Research Support; Self; Thermalin Diabetes, LLC.. Advisory Panel; Self; Thermalin Diabetes, LLC.. Stock/Shareholder; Self; Thermalin Diabetes, LLC.. Research Support; Self; National Institutes of Health, JDRF. Speaker's Bureau; Self; Capillary Biomedical, Inc..
Effectiveness of V-Go Wearable Insulin Delivery for Basal-Bolus Therapy—A Multicenter, Retrospective Real-World Evaluation in Type 2 Diabetes
Authors: HUNDAL RIPU S. , KOWALYK STEPHAN , CASES JANE , AL-KARADSHEH AMER , WAKIM AMANDA P. , DOYLE MELISSA , SINK JOHN H. , SPENCE ADRIENNE , BREWER JAMIE L. , NIKKEL CARLA C. 
Published: June 2018

With disease progression, the need to intensify therapy with insulin is often required in patients with T2D to improve glycemic control. Addressing the manner in which insulin is delivered may impact outcomes. The purpose of this study was to broadly evaluate the clinical benefits of switching from insulin delivery via insulin pen/syringe to a wearable insulin delivery device (V-Go) in patients with T2D across multidisciplinary investigators spanning 8 states. A retrospective analysis of electronic medical records evaluated change in A1C, insulin total daily dose (TDD) and weight in 283 patients. Baseline mean ± SD characteristics were A1C 9.2 ± 1.5%, BMI 34.8 kg/m2 ± 6.7, weight 221 ± 45 lbs and TDD 76 ± 47 u/day (range 14 to 300) with basal-bolus (n=192, 68%), basal (n=64, 23%) and premix (n=15, 5%) regimens being predominately prescribed. Concomitant anti-hyperglycemic agents were prescribed in 77% of patients with a mean of 1.7 ± 0.8 agents/patient prescribed. Effect of V-Go was evaluated following a mean duration of 2.9 ± 1.3 and 7.1 ± 3.0 months of use. Significant decreases in A1C and TDD were observed at both time points. Change in weight was significant (+2.3 lbs; P&lt;0.0001) at the first time point, however, was not significant (+2.1 lbs; P=0.106) by the second time point. Switching to insulin delivery with V-Go proved clinically beneficial compared to prior therapy.

Disclosure
R.S. Hundal: Speaker's Bureau; Self; Valeritas, Inc., Abbott, Boehringer Ingelheim Pharmaceuticals, Inc., AstraZeneca, Novo Nordisk Inc., Amarin Corporation, Eli Lilly and Company, Merck & Co., Inc. S. Kowalyk: Speaker's Bureau; Self; Valeritas, Inc.. J. Cases: None. A. Al-Karadsheh: None. A.P. Wakim: Speaker's Bureau; Self; Versartis, Inc.. Research Support; Self; Valeritas, Inc.. M. Doyle: None. J.H. Sink: Other Relationship; Self; Janssen Pharmaceuticals, Inc., valeritas. Speaker's Bureau; Self; Novo Nordisk Inc.. Consultant; Self; Becton, Dickinson and Company. A. Spence: None. J.L. Brewer: Speaker's Bureau; Self; Valeritas, Inc., Janssen Pharmaceuticals, Inc. C.C. Nikkel: Employee; Self; Valeritas, Inc.. Stock/Shareholder; Self; Valeritas, Inc..
Clinical Outcomes with V-Go in Type 2 Diabetes Based on Duration of Diabetes
Authors: CASES JANE , KOWALYK STEPHAN , HUNDAL RIPU S. , AL-KARADSHEH AMER , WAKIM AMANDA P. , DOYLE MELISSA , SINK JOHN H. , SPENCE ADRIENNE , BREWER JAMIE L. , NIKKEL CARLA C. 
Published: June 2018

A retrospective analysis was conducted to determine if duration of diabetes impacted clinical outcomes when switching from insulin pens/syringes to a wearable insulin delivery device (V-Go) in patients inadequately controlled. Patients (N=186) with T2D were stratified based on known duration of diabetes. A1C and insulin total daily dose (TDD) were extracted at baseline and two follow-up visits for each stratum. Paired t-tests were used to compare changes in A1C and TDD and a one-factor repeated measures ANCOVA model was performed to test for differences between groups with duration of diabetes as the factor and the corresponding baseline measurement as the covariate. Seventy-two percent of patients switched to V-Go had been diagnosed with diabetes for ≥ 10 years and 58% were switched to V-Go from conventional basal-bolus therapy. Clinical outcomes on V-Go were evaluated after a mean of 3 and 7 months. Regardless of duration of diabetes strata, significant reductions in A1C from baseline were observed. Further, all strata benefited from reductions in TDD with the exception of the duration stratum with the lowest baseline TDD (15 to 20 years), which maintained similar dosing on V-Go compared to baseline. By 7 months, no between group differences were observed for changes in A1C or TDD when controlling for baseline measurements. Insulin delivery with V-Go proved clinically beneficial regardless of duration of diabetes.

Disclosure
J. Cases: None. S. Kowalyk: Speaker's Bureau; Self; Valeritas, Inc. R.S. Hundal: Speaker's Bureau; Self; Valeritas, Inc., Abbott, Boehringer Ingelheim Pharmaceuticals, Inc., AstraZeneca, Novo Nordisk Inc., Amarin Corporation, Eli Lilly and Company, Merck & Co., Inc.. A. Al-Karadsheh: None. A.P. Wakim: Speaker's Bureau; Self; Versartis, Inc.. Research Support; Self; Valeritas, Inc.. M. Doyle: None. J.H. Sink: Other Relationship; Self; Janssen Pharmaceuticals, Inc., valeritas. Speaker's Bureau; Self; Novo Nordisk Inc.. Consultant; Self; Becton, Dickinson and Company. A. Spence: None. J.L. Brewer: Speaker's Bureau; Self; Valeritas, Inc., Janssen Pharmaceuticals, Inc. C.C. Nikkel: Employee; Self; Valeritas, Inc.. Stock/Shareholder; Self; Valeritas, Inc..
Efficacy of IDegLira vs. Basal-Bolus Therapy in Subjects with Type 2 Diabetes in DUAL VII by Baseline Characteristics
Authors: BILLINGS LIANA K. , KLONOFF DAVID C. , TENTOLOURIS NIKOLAOS , GRØN RANDI , HALLADIN NATALIE , JÓDAR ESTEBAN 
Published: June 2018

In 5subjects with type 2 diabetes uncontrolled on metformin and basal insulin, the DUAL VII trial (NCT02420262) demonstrated that a once-daily injection of insulin degludec/liraglutide (IDegLira) was non-inferior to multiple injections of basal-bolus therapy (insulin glargine 100 units/mL + insulin aspart before each main meal) for A1C reduction, and was associated with a significantly lower risk of hypoglycemia. This non-prespecified post-hoc analysis examined whether the efficacy results persisted across sub-groups for six different variables and evaluated whether benefits seen in the trial were applicable across a broad patient population. After 26 weeks of treatment, there was no significant difference in A1C reduction between IDegLira compared with basal-bolus in any baseline characteristic group (A1C, BMI, age, diabetes duration, total daily insulin dose and fasting plasma glucose [Table]). Additionally, there was no significant interaction between treatment and baseline sub-group for any of the baseline characteristics (Table).
In conclusion, the A1C lowering was comparable between once-daily IDegLira vs. basal-bolus therapy after 26 weeks of treatment, irrespective of baseline characteristics, which underscores the general application of these findings to a broad patient population.

Disclosure
L.K. Billings: Advisory Panel; Self; Novo Nordisk A/S, Sanofi. Consultant; Self; Novo Nordisk A/S. Research Support; Self; Novo Nordisk A/S. Speaker's Bureau; Self; Novo Nordisk A/S, Dexcom, Inc. D.C. Klonoff: Consultant; Self; Ascensia Diabetes Care, Lifecare, Intarcia Therapeutics, Inc., Voluntis USA, Novo Nordisk Inc., Onduo, Trividia Health, Inc., American Diabetes Association, The Endocrine Society, American Association of Diabetes Educators. N. Tentolouris: Advisory Panel; Self; MSD K.K., AstraZeneca, Sanofi, Novo Nordisk A/S, Elpen Pharmaceutical Co. Inc., Eli Lilly and Company, Boehringer Ingelheim GmbH, Novartis AG. Research Support; Self; MSD K.K., Eli Lilly and Company, Novo Nordisk A/S, Sanofi, Pfizer Inc., AstraZeneca, Janssen-Cilag Pty Limited, GlaxoSmithKline plc., Novartis AG. R. Grøn: Employee; Self; Novo Nordisk A/S. N. Halladin: Employee; Self; Novo Nordisk A/S. E. Jódar: Advisory Panel; Self; Janssen Pharmaceuticals, Inc., Eli Lilly and Company, Merck Sharp & Dohme Corp., Novo Nordisk A/S. Research Support; Self; Janssen Pharmaceuticals, Inc., Eli Lilly and Company, Merck Sharp & Dohme Corp., Novo Nordisk A/S, Pfizer Inc., Sanofi. Speaker's Bureau; Self; Janssen Pharmaceuticals, Inc., Eli Lilly and Company, Merck Sharp & Dohme Corp., Novo Nordisk A/S.
Kei Hea Te Reo? Where is the Language?
Authors: Cleave Peter 
Published: June 2018

Ko te patai e whaingia nei ko ‘Kei hea te reo?’. E tika ana pea kia pataingia hokitia, ‘He aha te reo?’
The question is ‘Where is the reo?’ It is also appropriate perhaps to ask ‘What is the reo?’
E ai ki te marearea ko te reo Maaori, he momo reo mai i a Raiaatea, mai i Te Moana nui a Kiwa. Kia whakakuitihia teenei, he reo mai i Te Moana nui a Kiwa ki te Raawhiti, he reo wheenaa i teenaa ki a Rarotonga, Hawaii, Rapa Nui me ngaa moutere ki waaenganui.
The proposition usually is that te reo Maori is a Pacific language. The standard approach is to narrow that down to a language of Eastern Polynesia sharing features with the languages of the Cook Islands, Hawaii, Easter Island and points in between.
Reconstruction of Law of Joint Property Distribution due to Divorce to the Working Husband and Wife Based on the Value of Justice
Authors: Erowati Eti Mul 
Published: June 2018

Abstract
Article 97 of Compilation of Islamic Law stated that a divorced widow or widower gets half part of the joint property. The application of the article also cannot be separated from 31 and 34 of Law No. 1 of 1974 on Marriage. However, Article 97 of Compilation of Islamic Law will not be considered fair and could not explain or resolve a problem if there is a wife who not only becomes a housewife, but also a housekeeper that provides the needs for the family (work). The results showed that in certain cases the judge has made a breakthrough related to the distribution of joint property due to divorce n which the wife is working to help husband to meet domestic life. The Verdict of Religious High Court of Padang No.38/Pdt.G/2013/PTA.Pdg. Establishes 1/3 of joint property for the Plaintiff (husband) and 2/3 of the property for the Defendant (wife) with a basic consideration in acquiring joint property of the Plaintiff and Defendant during the marriage, the Defendant is more dominant in the contribution of joint property and actively works as civil servants. Factor that influences the verdict which does not achieve justice is “legal substance factor”, “legal structure factor”, and “culture of law factors". Reconstruction of value of joint property distribution due to divorce is done based on the contribution by taking into account the benefit and detriment.
The Relation between Business and Authority: Maros Political Atmospheric Study in Indonesia
Authors: Sumandiyar Adi 
Published: June 2018

Abstract
The purpose of this study is to get the in-depth information about the patterns of relationship between the authorities and business groups on the political atmosphere in Maros, Indonesia This research was conducted using qualitative method with a constructivist approach. Data were obtained through advertising and electronic media in which the researcher acted as the research instrument. The data were used to investigate the relationship between the authorities and entrepreneurs on the political atmosphere in Maros, Indonesian The sources consisted of documentation and informants. The technique used in this study was in-depth interviews. Furthermore, the data were analyzed by interactive analysis intended to look at the process, the meaning, and the effect of the production and reproduction of the discourse. The results showed that the power of relation between the authorities and business groups had two objective and subjective dimensions and reacted reciprocally in producing up to reproducing the discourse of power that resulted in support for the authorities group of top level, midlevel, and the lowest authority levels in the region.
The development of verbal morphology and word order in an Indonesian-German bilingual child: A case study
Authors: Adnyani Ni Luh Putu Sri , Beratha Ni Luh Sutjiati , Pastika I Wayan , Suparwa I Nyoman 
Published: June 2018

AbstractThe contexts and circumstances of the occurrence of cross-linguistic influence in bilingual children’s language development are still a matter of debate. The present study argues that in the early development of a bilingual child exposed to two typologically distinct languages (Indonesian and German), the child developed two separate linguistic systems. The child, raised in Indonesia, was exposed to Indonesian by her Indonesian mother and to German by her German father. The study focuses on the early stages of verbal morphology and word order, from ages 1;3 to 2;2. The corpus took the form of conversational text or speech based on spontaneous interactions in natural settings. The data was collected using diary records, supplemented by weekly video recordings. In analysing the data, two software systems were used: ELAN and Toolbox. The speech was segmented based on utterances. All verbal morphology and word order was coded. The results show that verbal morphology in Indonesian and German was acquired by the child at different times, with the development of German verbs occurring later than Indonesian verb acquisition. In addition, there is evidence of interaction between the two developing systems. Cross-linguistic interference was identified when the child used the Indonesian vocatives-predicate combination in German utterances while, at the same time, the child also applied the German verb-final clause structure in Indonesian utterances when she should have produced German utterances. Thus, the results from this case study suggest that both language external and internal factors account for the occurrence of cross-linguistic influence.
Clinimetric Testing of the Lumbar Spine Instability Questionnaire
Authors: Saragiotto Bruno T. , Maher Chris G. , New Charles H. , Catley Mark , Hancock Mark J. , Cook Chad E. , Hodges Paul W. 
Published: June 2018

Background The Lumbar Spine Instability Questionnaire (LSIQ) is a self-report measure of 15 items. Previous studies have used the LSIQ as a measure of clinical instability; however, a comprehensive evaluation of its clinimetric properties has not been conducted. Objectives The aim of this study was to evaluate the clinimetric properties of the LSIQ in patients with chronic nonspecific low back pain (LBP). Methods In this clinical measurement study, the authors included patients with nonspecific LBP presenting to primary care clinicians in Australia. Rasch analysis was conducted to assess item hierarchy, targeting, unidimensionality, person fit, internal consistency, and differential item functioning. The researchers assessed test-retest reliability of total scores and individual item scores, as well as convergent and divergent validity. Results A total of 107 participants with LBP (60 men and 47 women) were recruited. The results were variable. The LSIQ appeared to constitute a unidimensional measure, targeted the sample well, and showed adequate test-retest reliability. However, the scale had poor internal consistency, did not appear to function as an interval-level measure, and had unclear construct validity. Although no items appeared to be redundant, several items were biased by factors other than the proposed construct of the measure. Conclusion The LSIQ does not seem to be ready to be implemented in clinical practice and may require theoretical reconsideration. Although the LSIQ provided satisfactory estimates for some clinimetric features, the authors do not consider the instrument to be useful as an interval-level measure but rather as an index. Future studies are needed to investigate whether the LSIQ could measure clinical instability or some other construct. J Orthop Sports Phys Ther 2018;48(12):915–922. Epub 22 Jun 2018. doi:10.2519/jospt.2018.7866
Tanpınar’ın Saklı Dünyası: Arayışlar-Keşifler-Yorumlar
Authors: AKBAŞ Onur 
Published: June 2018

Kimi eserlerin yorumlanmasında
bazı dönemde, devrin şartlarına da bağlı olarak, nicelik açısından çıta
yükselir ya da alçalır. Bu bağlamda Ahmet Hamdi Tanpınar, Cumhuriyet tarihi
boyunca çıtası hep yükselen bir yazar olmuştur. Bunda onun devrine hem edebiyat
tarihçisi hem de bir sanatkâr olarak hâkim bir kişiliğe sahip olmasının yanında
üzerinde imzası bulunan edebi metinlerin alegori açısından zengin ve her biri
adeta bir sanatkârın sanatı bağlamında ironisi olmalarıdır. Hakkında ortaya
konulan pek çok çalışma olmasına rağmen bu çalışmaların artan sayıları
bağlamında nitelikli olanlarının dikkatlere sunulması gerektiğine inanıyoruz. Şubat 2018 tarihinde basılan,
Doğu-Batı yayınlarından çıkan ve editörlüğünü İbrahim Şahin ve Julian
Rentszch’nin yaptığı Tanpınar üzerine yazılmış makaleler seçkisi. Ancak ortaya
konulan makaleleri nitelikli kılan, her bir makalenin işlendiği konu
bağlamında, yazarın sanat kaygısını da göz önünde bulundurmalarıdır. Önsözde
Prof. Dr. İbrahim Şahin’in de ifade ettiği gibi: “Yazarların heterojenliği,
makalelerin biçim içerik ve yorum açısından da birbirinden çok farklı olmasına
yol…” (Şahin, 2018, 12) açmış olması her açıdan kitaptaki çeşit zenginliğini
sağlamış.
Sistem Pakar Untuk Mendiagnosis Penyakit Stroke Hemoragik dan Iskemik Menggunakan Metode Dempster Shafer
Authors: Kanggeraldo Jansen , Sari Rika Perdana , Zul Muhammad Ihsan 
Published: June 2018

Stroke merupakan penyakit yang berhubungan dengan aliran darah ke otak. Biasanya, stroke disebabkan oleh adanya pembuluh darah yang pecah atau terhambat oleh gumpalan darah. Menurut data riset kesehatan dasar oleh Badan Litbangkes Kementerian Kesehatan RI (2013), stroke telah menjadi salah satu penyakit mematikan di Indonesia. Salah satu upaya yang dilakukan untuk mencegah stroke ialah dengan membuat sistem yang dapat mendiagnosa penyakit stroke. Berdasarkan penelitian Indraswari (2015), diperoleh hasil bahwa stroke dapat didiagnosis melalui kriteria faktor resiko. Namun, untuk mendapatkan data tersebut, tentunya pasien harus melakukan pengecekan ke rumah sakit atau laboratorium dahulu. Untuk mengatasi permasalahan tersebut, maka penulis membuat sistem pakar yang dapat mendiagnosis penyakit stroke tanpa harus berkonsultasi langsung kepada dokter. Sistem pakar ini mengadopsi kepakaran dari dokter spesialis saraf.. Hasil diagnosis sistem ini berupa jenis penyakit dan persentase nilai probabilitas terhadap penyakit stroke. Setelah dilakukan pengujian black box, didapatkan hasil bahwa seluruh fungsionalitas sistem telah terpenuhi. Lalu, berdasarkan hasil pengujian white box, nilai cyclomatic complexity yang didapatkan setelah dilakukan optimasi kode program adalah 8, hal tersebut menunjukkan kode program metode Dempster Shafer termasuk kode program sederhana tanpa banyak resiko. Tingkat keakurasian sistem pakar adalah 97% sehingga sistem dapat dijadikan alternatif bagi pasien untuk melakukan diagnosis penyakit stroke.
Helicobacter Pylori is the Cause of Gastric Cancer
Authors: Barukcic Ilija 
Published: June 2018

Objective: This study presents a systematic meta-analysis of the relationship between Helicobacter pylori (HP) infection and gastric cancer (GC).
Materials and Methods: Twelve articles including 21589 subjects were selected (1237 cases and 20352 controls). These data were analyzed using the mathematical formula of the conditio sine qua non relationship and the causal relationship formula.
Results: The data re-analyzed support the Null hypothesis without a Helicobacter pylori infection no human gastric cancer. The causal relationship between HP and GC is highly significant.
Conclusion: Helicobacter pylori is the cause of human gastric cancer.
Application of Genetic Algorithm and Personal Informatics in Stock Market
Authors: Albeladi Khulood , Abdullah Salha 
Published: June 2018

The financial market is extremely attractive since it moves trillion dollars per year. Many investors have been exploring ways to predict future prices by using different types of algorithms that use fundamental analysis and technical analysis. Many professional speculators or amateurs had been analysing the price movement of some financial assets using these algorithms. The use of genetic algorithms, neural networks, genetic programming combined with these tools in an attempt to find a profitable solution is very common. This study presents a prototype that utilizes genetic algorithms (GAs) and personal informatics system (PI) for short-term stock index forecast. The prototype works according to the following steps. Firstly, a collection of input variables is defined through technical data analysis. Secondly, GA is applied to determine an optimal set of input variables for a one-day forecast. Â The data is gathered from the Saudi Stock Exchange as being the target market. Thirdly, PI is utilised to create a smart environment, which enables visualisation of stock prices. The outcome indicates that this approach of forecasting the stock price is positive. The highest accuracy obtained is 64.67% and the lowest one is 48.06%.