bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Match‐Then‐Predict Method for Daily Traffic Flow Forecasting Based on Group Method of Data Handling
Authors: Song Xiang , Li Wenjing , Ma Dongfang , Wang Dianhai , Qu Licheng , Wang Yinhai 
Published: June 2018

AbstractForecasting daily traffic flow in the future is one of the most critical components in traffic management to improve operational efficiency. This article aims to address the daily traffic flow forecasting problem given historical data. Because the traffic flow pattern is strongly correlated with contextual factors, we propose a match‐then‐predict method which integrates contextual matching and time series prediction based on group method of data handling (GMDH) algorithm. From a Seattle‐based case study, we show that the contextual matching can significantly improve the prediction accuracy. We also show that the proposed method can in general outperform alternative prediction methods in daily traffic flow forecasting in terms of prediction accuracy. In addition, further analysis using data from other cities and applying the proposed method to forecast speed also support the benefits of the proposed method against alternative prediction methods.
The importance of residual kidney function in haemodialysis patients
Authors: Kong Jessica , Davies Matthew , Mount Peter 
Published: June 2018

ABSTRACTIn contrast to peritoneal dialysis, residual kidney function (RKF) is commonly disregarded for haemodialysis (HD) patients and not regularly monitored or taken into account in routine clinical care. This is despite evidence that higher levels of RKF in HD patients are associated with better outcomes, including survival, total solute clearance, nutrition, inflammation and fluid balance. This review aims to summarise the clinical effects of RKF specifically in HD patients. Some level of RKF is present in over 80% of patients at the time of dialysis initiation, and while this declines over time, up to 30% of patients on HD for 5 years still have a measurable level of native kidney function. There is little evidence on how best to preserve RKF in HD patients, although it has been observed that intensive HD regimens in incident HD patients appear to accelerate RKF decline. RKF is not commonly factored into HD prescription and measures of adequacy, despite the fact that some guidelines such as Kidney Disease Outcomes Quality Initiative (KDOQI) and European Best Practice Guidelines suggest that it is reasonable to do so. This likely relates, at least in part, to perceived concerns regarding the inconvenience of timed urine collections and to the complexity and lack of consensus regarding the methods for integrating the intermittent clearance of HD with the continuous clearance of native renal function. Further research is required into how best to maintain and maximise the benefits of RKF in HD patients.
Barriers to first time parent groups: A qualitative descriptive study
Authors: Barrett Norma , Hanna Lisa , Fitzpatrick Owen Vincent 
Published: June 2018

AbstractFirst‐time parents' groups are offered to new parents in Australia to support their transition to parenthood. Not all parents avail of the service, some cease attendance, and fathers are under‐represented. In the present descriptive, qualitative study, we examined first‐time mothers' perspectives on the barriers to parental participation in the groups. Semi‐structured interviews were conducted with a sample of eight first‐time mothers in a regional city in Victoria, Australia. Interviews revealed groups were perceived as sites strongly reinforcing traditional social norms of parenting. From this central theme, six gendered subthemes emerged as barriers to attendance. Barriers to mothers included non‐normative mothering narratives, such as experiencing stillbirth or having a disabled child, perceived dissonance in parenting ethos, and group size. Barriers to fathers, as perceived by mothers, included groups as female spaces, dads as a minority, and female gatekeeping. A multi‐faceted approach is required to change the common perception that groups are for mothers only. Groups need to be more inclusive of different parenting experiences and philosophies. Segregated groups might better address the needs of both parents. Further research is required to capture fathers' perspectives.
Calcium transport across plant membranes: mechanisms and functions
Authors: Demidchik Vadim , Shabala Sergey , Isayenkov Stanislav , Cuin Tracey A. , Pottosin Igor 
Published: June 2018

ContentsSummary49I.Introduction49II.Physiological and structural characteristics of plant Ca2+‐permeable ion channels50III.Ca2+extrusion systems61IV.Concluding remarks64Acknowledgements64References64SummaryCalcium is an essential structural, metabolic and signalling element. The physiological functions of Ca2+are enabled by its orchestrated transport across cell membranes, mediated by Ca2+‐permeable ion channels, Ca2+‐ATPases and Ca2+/H+exchangers. Bioinformatics analysis has not determined any Ca2+‐selective filters in plant ion channels, but electrophysiological tests do reveal Ca2+conductances in plant membranes. The biophysical characteristics of plant Ca2+conductances have been studied in detail and were recently complemented by molecular genetic approaches. Plant Ca2+conductances are mediated by several families of ion channels, including cyclic nucleotide‐gated channels (CNGCs), ionotropic glutamate receptors, two‐pore channel 1 (TPC1), annexins and several types of mechanosensitive channels. Key Ca2+‐mediated reactions (e.g. sensing of temperature, gravity, touch and hormones, and cell elongation and guard cell closure) have now been associated with the activities of specific subunits from these families. Structural studies have demonstrated a unique selectivity filter inTPC1, which is passable for hydrated divalent cations. The hypothesis of aROS‐Ca2+hub is discussed, linking Ca2+transport toROSgeneration.CNGCinactivation by cytosolic Ca2+, leading to the termination of Ca2+signals, is now mechanistically explained. The structure–function relationships of Ca2+‐ATPases and Ca2+/H+exchangers, and their regulation and physiological roles are analysed.
Meiotic chromosome stability of a newly formed allohexaploid wheat is facilitated by selection under abiotic stress as a spandrel
Authors: Bian Yao , Yang Chunwu , Ou Xiufang , Zhang Zhibin , Wang Bin , Ma Weiwei , Gong Lei , Zhang Huakun , Liu Bao 
Published: June 2018

Summary

Polyploidy is a prominent route to speciation in plants; however, this entails resolving the challenges of meiotic instability facing abrupt doubling of chromosome complement. This issue remains poorly understood.

We subjected progenies of a synthetic hexaploid wheat, analogous to natural common wheat, but exhibiting extensive meiotic chromosome instability, to heat or salt stress. We selected stress‐tolerant cohorts and generated their progenies under normal condition. We conducted fluorescent in situ hybridization/genomic in situ hybridization‐based meiotic/mitotic analysis, RNA‐Seq and virus‐induced gene silencing (VIGS)‐mediated assay of meiosis candidate genes.

We show that heritability of stress tolerance concurred with increased euploidy frequency due to enhanced meiosis stability. We identified a set of candidate meiosis genes with altered expression in the stress‐tolerant plants vs control, but the expression was similar to that of common wheat (cv Chinese Spring, CS). We demonstrate VIGS‐mediated downregulation of individual candidate meiosis genes in CS is sufficient to confer an unstable meiosis phenotype mimicking the synthetic wheat.

Our results suggest that heritable regulatory changes of preexisting meiosis genes may be hitchhiked as a spandrel of stress tolerance, which significantly improves meiosis stability in the synthetic wheat. Our findings implicate a plausible scenario that the meiosis machinery in hexaploid wheat may have already started to evolve at its onset stage.
Exposure to hypoglycemia and risk of stroke
Authors: Smith Logan , Chakraborty Diya , Bhattacharya Pallab , Sarmah Deepaneeta , Koch Sebastian , Dave Kunjan R. 
Published: June 2018

AbstractIn the treatment of both type 1 and type 2 diabetes mellitus, maintaining a euglycemic state represents one of the key challenges. Improper dosing and administration of glucose‐lowering drugs is associated with an increased risk of recurrent hypoglycemia episodes. In addition, the risk of adverse cardiovascular events in diabetic patients, particularly myocardial infarctions and strokes, is well established. Current research indicates a potential link between the baseline risk of cardio/cerebrovascular events in diabetic patients and exposure to hypoglycemia. In this review of the literature, we aim to determine if a relationship exists between recurrent hypoglycemia and adverse neurovascular events.
Telemedicine as a tool for digital medical education: a 15‐year journey inside the RAFT network
Authors: Randriambelonoro Mirana , Bagayoko Cheick‐Oumar , Geissbuhler Antoine 
Published: June 2018

AbstractThis paper presents the evolution and growth of continuous medical education through the Réseau en Afrique Francophone pour la Télémédecine (RAFT) network. RAFT is a telemedicine network present on four continents and built through years of experience, with the goal of supporting isolated healthcare professionals by providing them with the right expertise at the right time using affordable, low‐bandwidth technologies. Much more than a platform to share and exchange knowledge, RAFT has put in place a solid local infrastructure to ensure the sustainability and maintenance of the network. From experience gained with South–South collaboration to top‐down and bottom‐up approaches and various certification models, much know‐how has been acquired and different perspectives for improvement have been proposed. The results we have collected from these 15 years of practice are presented in this paper through lessons learned and key takeaways. Perspectives for future development supported by concrete examples conclude the paper.
Time to consider the contact force during photoplethysmography measurement during pediatric anesthesia: A prospective, nonrandomized interventional study
Authors: Lee Ji‐Hyun , Yang Seungman , Park Jonghyun , Kim Hee Chan , Kim Eun‐Hee , Jang Young‐Eun , Kim Jin‐Tae , Kim Hee‐Soo 
Published: June 2018

SummaryBackgroundRespiratory variations in photoplethysmography amplitude enable volume status assessment. However, the contact force between the measurement site and sensor can affect photoplethysmography waveforms. We aimed to evaluate contact force effects on respiratory variations in photoplethysmography waveforms in children under general anesthesia.MethodsChildren aged 3‐5 years were enrolled. After anesthetic induction, mechanical ventilation commenced at a tidal volume of 10 mL/kg. Photoplethysmographic signals were obtained in the supine position from the index finger using a force sensor–integrated clip‐type photoplethysmography sensor that increased the contact force from 0‐1.4 N for 20 respiratory cycles at each force. The AC amplitude (pulsatile component), DC amplitude (nonpulsatile component), AC/DC ratio, and respiratory variations in photoplethysmography amplitude were calculated.ResultsData from 34 children were analyzed. Seven contact forces at 0.2‐N increments were evaluated for each patient. The normalized AC amplitude increased maximally at a contact force of 0.4‐0.6 N and decreased with increasing contact force. However, the normalized DC amplitude increased with a contact force exceeding 0.4 N. ΔPOP decreased slightly and increased from the point when the AC amplitude started to decrease as contact force increased. In a 0.2‐1.2 N contact force range, significant changes in the normalized AC amplitude, normalized DC amplitude, AC/DC ratio, and respiratory variations in photoplethysmography amplitude were observed.ConclusionRespiratory variations in photoplethysmography amplitude changed according to variable contact forces; therefore, these measurements may not reflect respiration‐induced stroke volume variations. Clinicians should consider contact force bias when interpreting morphological data from photoplethysmography signals.
Downregulation of CD5 and dysregulated CD8+ T‐cell activation
Authors: Wada Taizo 
Published: June 2018

AbstractCD5 is a cell surface molecule that is expressed on most circulating T cells and a small population of B cells, and is involved in modulation of antigen‐specific receptor‐mediated activation. Downregulation of CD5 on CD8+ T cells is a poorly understood but increasingly recognized phenomenon that may be associated with dysregulated T‐cell activation. An increased subpopulation of activated CD8+ T cells with downregulation of CD5 has recently been described in patients with Epstein–Barr virus‐associated hemophagocytic lymphohistiocytosis (HLH) and familial HLH caused by perforin deficiency and Munc 13‐4 deficiency. These cells were detectable only in the acute phase of HLH, in which patients exhibited hypercytokinemia, and declined progressively after successful treatment in parallel with improvement of systemic inflammation. It is unknown whether CD8+ T cells from HLH with other causes have similar profiles. Assessment of CD5 expression on T cells has the potential to assist in the understanding of the diagnosis and pathogenesis of human inflammatory diseases such as HLH.
Hepatosplenic γδ T‐cell lymphoma of two adolescents: Case report and retrospective literature review in children, adolescents, and young adults
Authors: McThenia Sheila S. , Rawwas Jawhar , Oliveira Jennifer L. , Khan Shakila P. , Rodriguez Vilmarie 
Published: June 2018

AbstractHSTCL is a highly aggressive malignancy with a poor prognosis. Case series and accounts have reported the use of different chemotherapy regimens with diverse patient outcomes. Most long‐term survivors had undergone high‐dose chemotherapy with autologous or allogeneic HCT. We describe two pediatric patients with HSTCL who were treated with chemotherapy followed by allogeneic HCT. Both patients are alive and in complete remission 2 and 8 years after therapy. Multiagent chemotherapy followed with allogeneic HCT seems to provide patients who have chemotherapy‐sensitive disease a long‐term disease‐free survival.
Education, enjoyment, and empowerment: Outcomes of an adolescent transplant camp (I own it)
Authors: Kesavarapu Keerthana , Palle Sirish K. , Dugan Molly , Antinerella Shannon , Luetkemeyer Shannon , Gupta Nitika 
Published: June 2018

AbstractPeer group camping experiences have a positive influence on adolescents with chronic illnesses, but the data in solid organ transplant recipients are lacking. The aim of this study was to evaluate the outcomes of adolescent transplant attendees of an educational camp. A weekend camp, “I own it” was organized which provided educational training regarding career and health choices, money matters, and managing medications following which a knowledge assessment was performed. The ACLSA questionnaire was also administered. To test the adolescents’ medication knowledge, they were asked to provide written documentation of their medications, which was compared with their medical records. In the ACLSA questionnaire, 32% reported deficiency in work/study, 46% in housing/money management, and 3% in the remaining categories. A significant improvement in knowledge was noted in areas of career choices, money matters, and managing medications, but not in healthy choices. In the medication recall, 75% did not know their medication list, and 92% could not recall dosages or frequencies. In conclusion, adolescents showed quantitative improvements in certain areas while identifying deficiencies in others, areas which were targeted in future initiatives. Prospective longitudinal studies addressing the impact of camps on post‐transplant outcomes should be conducted to better alter the course post‐transplant.
Selective T cell‐depleted haploidentical hematopoietic stem cell transplantation for relapsed/refractory neuroblastoma
Authors: Liu Anthony P. Y. , Lee Pamela P. W. , Kwok Janette S. Y. , Leung Rock Y. Y. , Chiang Alan K. S. , Ha Shau‐Yin , Cheuk Daniel K. L. , Chan Godfrey C. F. 
Published: June 2018

AbstractRelapsed/refractory NB carries a bleak outcome, warranting novel treatment options. HaploHSCT induces a graft‐versus‐NB effect via natural killer cell alloreactivity. Review of patients with relapsed/refractory NB who underwent haploHSCT with ex vivo T‐cell depletion in our unit from 2013 through 2018. Ten patients were identified (male=5; median age at haploHSCT=6.45 y, range: 3.49‐11.02 y). Indications were relapsed in 7 and refractoriness in 3; disease status at haploHSCT was CR in 2, PR in 6, and PD in 2. All patients received peripheral blood stem cell grafts after ex vivo T‐cell depletion (CD3/CD19‐depletion=1; TCR‐αβ/CD19‐depletion=4; CD3/CD45RA‐depletion=4; and TCR‐αβ/CD45RA‐depletion=1). Conditioning regimens were fludarabine‐based. Neutrophils engrafted on median D + 10 (range: D + 9 to +13), and platelets engrafted (≥20 × 109/L) on median D + 8 (range: D + 5 to D + 14). Early T‐ and NK‐cell recovery were evident. Of the 10 patients, acute rejection developed in 1 (who died of PD despite rescue HSCT), and 1 died of sepsis before engraftment; 8 experienced full donor‐chimerism post‐HSCT. Among the 8, 6 experienced CR, 1 died of PD, and 1 died of pulmonary hypertensive crisis before evaluation. At publication, 4 were in remission (2.8, 7.4, 28.5, and 58.9 months). No significant GvHD occurred. HaploHSCT with selective ex vivo T‐cell depletion may be a safe and useful salvage strategy for relapsed/refractory NB.
Small effort, high impact: Focus on physical activity improves oxygen uptake (VO2peak), quality of life, and mental health after pediatric renal transplantation
Authors: Thorsteinsdottir Hjørdis , Diseth Trond H. , Lie Anine , Tangeraas Trine , Matthews Iren , Åsberg Anders , Bjerre Anna 
Published: June 2018

AbstractThis study estimates the effects on peak oxygen uptake (VO2 peak), QoL, and mental health after the introduction of an adjusted post‐transplant follow‐up program, that is, early physiotherapy and focus on the importance of physical activity. VO2 peak was measured by a treadmill exercise test in 20 renal‐transplanted children on the adjusted post‐transplant follow‐up and compared with a group of 22 patients investigated in a previously, before the implementation of our new follow‐up routines. PedsQL and The Strengths and Difficulties Questionnaire (SDQ) were used to assess QoL and mental health in 45 patients on the new as compared to 32 patients on the previous follow‐up strategy. The patients exposed to early physiotherapy and a higher focus on physical activity had significantly higher VO2 peak (44.3 vs 33.5 mL kg−1 min−1, P = .031) in addition to improved QoL (P = .003) and mental health scores (P = .012). The cardiovascular risk profile was similar in both groups aside from significantly higher triglycerides in the present cohort. Small efforts as early physiotherapy and increased focus on physical activity after pediatric renal transplantation have significant impact on cardiorespiratory fitness, QoL, and mental health. The importance of physical activity should therefore be emphasized in follow‐up programs.
Effect of CYP3A5*1 expression on tacrolimus required dose for transplant pediatrics: A systematic review and meta‐analysis
Authors: Hendijani Fatemeh , Azarpira Negar , Kaviani Maryam 
Published: June 2018

AbstractThis systematic review was designed to find out optimal tacrolimus dose in pediatrics according to their CYP3A5*1 genotype by performing meta‐analysis. PubMed, Scopus, ISI web of Science, ProQuest, Cochrane library, and clinicaltrail.gov were systematically searched to find studies in which tacrolimus dose and/or blood concentration and/or concentration‐to‐dose (C/D) ratio were determined in genotype groups of CYP3A5*1 in pediatric population. Data were extracted at 14 time points post‐transplantation and meta‐analysis of mean and SD was performed. In all, 11 studies including 596 pediatric transplant recipients were entered into systematic review and meta‐analysis. Analysis of tacrolimus required dose, blood concentration, and C/D ratio in 14 time points post‐transplantation resulted in significant differences between expressers and non‐expressers of CYP3A5*1. It seems that 0.06 mg/kg/day higher tacrolimus dose in expressers can produce same blood level as non‐expressers. Using results of TDM for tacrolimus dose adjustment, it takes about 1 month for patients to reach stable and optimum tacrolimus blood concentration. This is too long time period which increases the risk of immunosuppressive over/under‐dose and drug toxicity or organ rejection. Considering our results, defining genetic profile helps to predict the individual required dose more rapidly, actually before beginning of treatment.
Antimicrobial Photodynamic Therapy as an Adjunct for Clinical Partial Removal of Deciduous Carious Tissue: A Minimally Invasive Approach
Authors: Ornellas Pâmela O. , Antunes Leonardo S. , Motta Paula C. , Mendonça Caroline , Póvoa Helvécio , Fontes Karla , Iorio Natalia , Antunes Lívia A. A. 
Published: June 2018

AbstractThis study aimed to evaluate the use of antimicrobial photodynamic therapy (aPDT) as an adjunct for minimally invasive treatment (partial removal of carious tissue—PRCT) of deciduous carious tissue evaluating its efficacy in reducing microorganisms. For that, a clinical study was design including children with deciduous molars with active deep caries lesions (DCL). PRCT was performed and remaining dentin was treated with 100 μg mL−1 methylene blue solution (5 min) and than irradiated with a low power laser emitting red light (InGaAIP—indium gallium aluminum phosphide; λ = 660 nm; 100 mW; 300 J cm−2; 90 s; 9 J). The colony forming units (CFU) count after PRCT and after PRCT + aPDT/mg of dentin were compared for total microorganisms, including Candida spp., the mutans streptococci group, Streptococcus spp. and Lactobacillus spp. The dentin was classified (color, consistency and humidity). The microbial reduction varied from 69.88% to 86.29% and was significantly observed for total microorganisms, mutans streptococci, Streptococcus spp. and Lactobacillus spp (P < 0.001). The dentin type did not influence reduction of microorganisms (P > 0.05). The aPDT presents a promising future for clinical use as an adjunct for the reduction of microorganisms in PRCT of DCL in all kinds of dentin.