bluuebunny/crossref_metadata_2025_split huggingface dataset:
179 Dasotraline in Children With Attention Deficit Hyperactivity Disorder: Results of a Randomized, Double-Blind, Placebo-Controlled Study
Authors: Goldman Robert , Adler Lenard , Spencer Thomas , Findling Robert , Hopkins Seth C. , Koblan Kenneth K. , Sarma Kaushik , Hsu Jay , Loebel Antony 
Published: June 2018

AbstractObjectivesOnce-daily dosing with dasotraline, a novel dopamine and norepinephrine reuptake inhibitor, achieves stable plasma concentrations over 24 hours with once-daily dosing. This study evaluated dasotraline in children aged 6–12 years (NCT02428088).MethodsPatients were randomized 1:1:1 to 6 weeks of once-daily, fixed-dose dasotraline 2 or 4 mg/day, or placebo. The primary efficacy endpoint was change from baseline (CFB) at Week 6 in ADHD Rating Scale Version IV – Home Version (ADHD RS-IV HV) total score, using a mixed model for repeated measures (MMRM) in the intent-to-treat (ITT) population. Secondary endpoints included Clinical Global Impression-Severity (CGI-S) score and safety endpoints.ResultsThe mean age of 342 randomized patients was 9.1 [SD: 1.9] years; 66.7% were male. Overall, 79% of patients completed the study. In the ITT population (N=336), ADHD RS-IV HV total score improved significantly with dasotraline 4 mg/day vs placebo(least squares [LS] mean [SE] CFB at Week 6: –17.53 [±1.31] vs –11.36 [±1.29], respectively, p<0.001; effect size [ES]: 0.48). Inattentiveness and hyperactivity/impulsivity subscale scores significantly improved with 4 mg/day vs placebo at Week 6 (p=0.001, p=0.003, respectively). Improvement in CGI-S score was statistically significant with dasotraline 4 mg/day vs placebo(LS mean [SE] CFB at Week 6: –1.39 [±0.12] vs –1.04 [±0.12], respectively, p=0.040; ES: 0.29). No significant improvement was observed on the ADHD RS-IV HV total score and the CGI-S score for dasotraline 2 mg/day vs placebo. The most frequent treatment-emergent AEs (≥5% and higher than placebo) were (2 mg/day; 4 mg/day; placebo): insomnia (15.3%; 21.7%; 4.3%, all terms combined), decreased appetite (12.6%; 21.7%; 5.2%), weight loss (5.4%; 8.7%; 0%), irritability (3.6%; 7.0%; 6.0%), nasopharyngitis (0.9%; 5.2%; 0.9%), and nausea (0%; 5.2%; 2.6%).ConclusionsCompared with placebo, dasotraline 4 mg/day significantly improved ADHD symptoms in children, as assessed by ADHD RS-IV HV total score and inattentiveness and hyperactivity/impulsivity subscale scores. Dasotraline was generally well tolerated; most common AEs were insomnia, decreased appetite, weight loss and irritability.Funding AcknowledgementsStudy sponsored by Sunovion Pharmaceuticals Inc.
182 Unintentional Overdose on Long-Acting Injectable Risperidone
Authors: Pasha Saira , Schilling Shirin 
Published: June 2018

AbstractStudy ObjectivesUnderstand the mechanism and pharmacokinetics involved in an unintentional overdose of injectableantipsychotic medication; identify how to transition between long acting injectable antipsychotics; formulate steps to ensure patient safety in an event of an unintentional overdose of injectable antipsychoticMethodReview of a case study involving a 47-year-old male, with history of schizoaffective disorder and previous episodes of loss of consciousness of unknown etiology, who was admitted to the inpatient psychiatry unit at UConn Health John Dempsey Hospital for stabilization of psychotic symptoms and monitoring of unintentional overdose after initially being admitted to the ICU. He was found unconscious at home following a period of days where he self-injected four of 37.5mg Risperidone injections (estimated 150mg) along with limited adherence to prescribed oral clozapine, doxepin and lorazepam. He reported self-injecting additional medication to treat paranoia, auditory, visual and olfactory hallucinations. In the ICU, he was evaluated by Toxicology and Neurology for loss of consciousness thought to be from seizures, with no clear outcome. He was awake and alert within 24 hours of medical admission but became agitated, hostile, and psychotic prompting psychiatric admission. When his worsening paranoia had resulted in termination of his visiting nurse services that administered injections and in home assessments, his outpatient psychiatrist allowed him to self-administer bi-monthly injections. Over three weeks in the hospital, he was evaluated for signs and symptoms of antipsychotic overdose.ResultsInitial literature review did not reveal information involving an overdose of injectable Risperidone. Thus, the time frame and symptoms to monitor were uncertain. As the injectable medication was expected to peak in 2-3 weeks and persist for 4-6 weeks, there was a concern about delayed potential side effects such as EPS, sedation, QTC prolongation and electrolytes imbalances. He was treated with oral antipsychotic medication. Clozapine and doxepin were discontinued due to patient non-adherence, side effects, and drug interactions. He exhibited signs of EPS and was started on benztropine. To simplify his regimen, he was switched to another long acting injectable, Paliperidone Palmitate, prior to his discharge.ConclusionsGiven the nature of the presentation, he was advised not to self-administer injectable medication and was referred for visiting nurse services. He was educated on the potential side effects of injectable antipsychotic medication. As there was a change in antipsychotic medications, follow up was recommended in an intensive outpatient program for psychotic symptoms and prolonged side effects. Due to the patient’s concordant episode of loss of consciousness, he was advised to follow up with an outpatient long term EEG monitoring and complete Neurology evaluation.Funding AcknowledgementsNo funding.
185 Second Generation Antipsychotics and Catatonia: A Literature Review
Authors: Slauer Ryan , Boazak Mina , Lowley Michael , Lawrence Jeffrey , Hudson Zachary , Goldsmith David , Cotes Robert 
Published: June 2018

AbstractIntroductionCatatonia is an underrecognized neuropsychiatric syndrome affecting approximately 10% of individuals hospitalized on inpatient psychiatric units. First-line treatments for this condition include benzodiazepines (BZD) and/or electroconvulsive therapy (ECT). However, 20-40% of individuals do not respond to BZD alone and ECT is not always accessible. Second generation antipsychotics (SGA) have been used to treat catatonia in these circumstances. Here, we review the literature pertaining to the efficacy and safety of SGA in the treatment of catatonia.MethodsWe conducted a PubMed search for articles linking catatonia to antipsychotics, under the search heading “catatonia” or “kahlbaum” and “risperidone”, “amisulpride”, “iloperidone”, “olanzapine”, “aripiprazole”, “paliperidone”, “clozapine”, “brexpiprazole”, or “cariprazine”. Reports commenting on SGA treatment efficacy and/or their role in the development of catatonia were included in the analysis. Selected articles were reviewed for patient demographics, psychiatric/medical history, symptoms, cause of catatonia and treatment, and co-administered agents. For each SGA, we calculated the number of cases in which catatonia was likely improved with antipsychotic treatment, and the number of cases in which catatonia was precipitated or worsened with antipsychotic treatment (improved/worsened ratio). Case data was assessed using the Naranjo Adverse Drug Reaction Probability Scale. Descriptive statistics were used to analyze the data.ResultsAt the time this abstract was written, we reviewed 480 of the original 507 articles. One hundred and seventeen of the 480 met inclusion criteria. There was one randomized controlled trial (RCT), five prospective studies, four retrospective studies and 107 case reports. Of all reviewed literature quetiapine (34:3, 92%), aripiprazole (16:2, 89%), amisulpride (18:1, 95%), andclozapine (19:1, 95%) had the highest improved/worsened ratio, conversely paliperidone (0:5, 0%) had the lowest improved/worsened ratio.ConclusionOf the available literature quetiapine, amisulpride, aripiprazole, and clozapine were found to be relatively safe andeffective as treatment options in catatonia, while palipderidone was found to have reports pointing to its role in the development/worsening, but none on the improvement, of catatonia. These results need to be interpreted with caution. In the majority of cases where SGA’s were effective, patients were co- treated with other pharmacologic agents (most frequently benzodiazepines), making it difficult to assess the role of the antipsychotic alone. Also, given that the preponderance of studies were case reports, publication bias may be an important limitation. Further studies are needed to examine the safety and efficacy of SGA in treating catatonia.Funding AcknowledgementsNo funding.
186 Hospital Utilization Rates Following Antipsychotic Dose Reductions Among Patients With Schizophrenia
Authors: Caroff Stanley N. , Mu Fan , Ayyagari Rajeev , Schilling Traci , Abler Victor , Carroll Benjamin 
Published: June 2018

AbstractIntroductionTardive dyskinesia (TD), an often-irreversible movement disorder, develops in patients treated withantipsychotics. Although antipsychotic dose reduction has been utilized in the management of TD, the benefits and risks of lowering doses have not been well studied and could cause additional burden to patients.ObjectiveTo analyze the healthcare burden of antipsychotic dose reduction in patients with schizophrenia.MethodsMedical claims from six US states spanning 6 years are retrospectively analyzed for ≥10% or ≥30% antipsychotic dosereductions and compared with those from patients receiving stable doses. Outcomes measured include inpatient admissions and emergency room (ER) visits for schizophrenia, all psychiatric disorders, and all causes.ResultsBaseline analysis revealed 17,984 patients with ≥10% and 14,029 patients with ≥30% dose reduction. Patients with≥10% dose reduction and matched controls were similar in age (mean 45.5 years), gender (51% male) and healthcare plan type. Preliminary analyses indicate that ≥10% dose reduction is associated with increased risk of admission or ER visit for schizophrenia (hazard ratio [HR] 1.26; 95% confidence interval [CI] 1.18, 1.35; P<0.001) and all psychiatric disorders (HR 1.18; 95% CI 1.11, 1.25; P<0.001) versus controls, which may be even greater with ≥30% dose reduction. Final updated results of ongoing analyses will be presented at the meeting.ConclusionsPatients with antipsychotic dose reductions may be at risk for significant increases in hospital utilization rates. This suggests that dose reductions may increase overall healthcare burden in some schizophrenia patients, and highlights the need for alternative strategies in the management of TD.Presented at: Psych Congress; September 16–19, 2017; New Orleans, Louisiana, USA.Funding AcknowledgementsThis study was funded by Teva Pharmaceutical Industries, Petach Tikva, Israel.
193 A New Syndrome: Phantogeusia-Induced Phantosmia
Authors: Ahmad Umar , Hirsch Alan R. 
Published: June 2018

AbstractCase ObjectiveWhile phantosmia-induced phantogeusia has been described (Ahmed, 20173), the reverse, phantogeusia-induced phantosmia, has not heretofore been described. Such a case is presented.MethodsCase Study: A 39-yr-old left-handed (pathological) male, six years prior to presentation, noted a sudden onset of phantogeusia of roast cooking, pizza, fruit, strawberries, or a sour taste, and shortly thereafter he would develop unpleasant phantosmias which would sometimes combine with the ambient aroma. These would occur 3-10 times per week and would last for the duration of the phantogeusia, for as long as 1-2 hours. Occasionally the phantosmia would occur first and then induce the phantogeusia of asour taste.ResultsAbnormalities in Neurologic examination: Mental status examination: Immediate recall: Digit span: 6 digits forward and 3 digits backwards. CN XI, X: Decreased gag bilaterally. Motor Examination: Drift: left pronator drift with right abductor digiti minimi sign and right cerebellar spooning. Gait Examination: Tandem Gait: unstable. Cerebellar Examination: Holmes Rebound Phenomena: bilaterally positive, left greater than the right. Sensory Examination: Ipswich Touch Test: decreased in left lower extremity. Temperature: decreased in left lower extremity. Rydel-Seiffer Vibratory Test: bilateral upper extremities 5, bilateral lower extremities 3. Reflexes: upper extremities 1+, absent lower extremities. Neuropsychiatric Examination: Go-No-Go Test: 6/6 (normal). Animal Fluency Test: 15 (normal). Clock Drawing Test: 3 (abnormal). Center for Neurologic Study Lability Scale: 16 (Pseudobulbar affect).ConclusionClose connection of the tertiary smell and taste integration areas, where smell and taste converge, in the posterior orbitofrontal cortex, anterior to the insular taste cortex, and posterior to the granular orbitofrontal cortex may have allowed activation of memory engrams connecting these two (Rolls, 19944). Alternatively, electrical discharge from the primary taste area may have spread to involve the cortical representation of smell. Since the cortical area involved in the interpretation and hedonics of taste co-localize with the area involving olfactory hedonics, spread from one area to the other area may occur. As a result of electrical discharge (from an epileptiform focus) or as a result of well-connected and developed memory engrams with associated hedonics, phantom tastes may induce phantom smells. Alternatively, this may represent a distorted retronasal smell whereby the olfactory component of the gustatory hallucination causes a discharge of the olfactory epithelium (a pseudoretronasal smell).Given the above, treatment of those with both phantosmia and phantogeusia may respond to treatment of phantogeusia alone. Under this construct, the phantosmia is the slave of the phantogeusia whereby management of the taste hallucination will thus eliminate the smell hallucination.Funding AcknowledgementsSmell and Taste Treatment and Research Foundation.
198 Who Am I: Delusion of Misidentification of Self
Authors: Moustafa Yara W. , Dalkilic Alican 
Published: June 2018

AbstractDelusional misidentification syndromes are rare psychotic disorders, in which the patient believes that the identity of a person, object, or place has been changed or replaced by another. These disorders include Capgras syndrome, Fregoli syndrome, and inter-metamorphosis. Reverse types of misidentification syndromes were introduced to distinguish alteration of the self rather than of others.Reverse Capgras syndrome refers to the psychological change of the self as opposed to others, while reverse Fregoli syndrome is the delusional belief in which the patient has undergone fundamental changes in physical makeup without any psychological changes, and reverse intermetamorphosis is a variant in which patients believe that they have undergone physical and psychological transformation.Here we present an interesting case of a transgender woman presenting with delusional misidentification of the self in the context of Schizophrenia. A review of literature, with emphasis on etiological factors, forensic implications and association with violence is presented.Funding AcknowledgementsNo funding.
Alignment of comparable documents: Comparison of similarity measures on French–English–Arabic data
Authors: LANGLOIS D. , SAAD M. , SMAILI K. 
Published: June 2018

AbstractThe objective, in this article, is to address the issue of the comparability of documents, which are extracted from different sources and written in different languages. These documents are not necessarily translations of each other. This material is referred as multilingual comparable corpora. These language resources are useful for multilingual natural language processing applications, especially for low-resourced language pairs. In this paper, we collect different data in Arabic, English, and French. Two corpora are built by using available hyperlinks for Wikipedia and Euronews. Euronews is an aligned multilingual (Arabic, English, and French) corpus of 34k documents collected from Euronews website. A more challenging issue is to build comparable corpus from two different and independent media having two distinct editorial lines, such as British Broadcasting Corporation (BBC) and Al Jazeera (JSC). To build such corpus, we propose to use the Cross-Lingual Latent Semantic approach. For this purpose, documents have been harvested from BBC and JSC websites for each month of the years 2012 and 2013. The comparability is calculated for each Arabic–English couple of documents of each month. This automatic task is then validated by hand. This led to a multilingual (Arabic–English) aligned corpus of 305 pairs of documents (233k English words and 137k Arabic words). In addition, a study is presented in this paper to analyze the performance of three methods of the literature allowing to measure the comparability of documents on the multilingual reference corpora. A recall at rank 1 of 50.16 per cent is achieved with the Cross-lingual LSI approach for BBC–JSC test corpus, while the dictionary-based method reaches a recall of only 35.41 per cent.
Integrated primary care: patient perceptions and the role of mental health stigma
Authors: Miller-Matero Lisa R. , Khan Shehryar , Thiem Rachel , DeHondt Tiffany , Dubaybo Hala , Moore Daniel 
Published: June 2018

Abstract
Some patients are more willing to see a behavioral health provider within primary care. The purpose of this study was to evaluate the patients’ perspectives of having access to a psychologist within primary care and to investigate whether mental health stigma affected preferences. In total, 36 patients completed questionnaires after seeing a psychologist in primary care. Patients were satisfied with having a primary care psychologist involved in their care. Most patients were more likely to see the psychologist in primary care and those who preferred this indicated higher levels of mental health stigma. The overarching theme for why patients saw a psychologist in primary care was convenience. Mental health stigma may also have played a role. Results suggest that providing integrated services may reach patients who may not have otherwise sought services in a behavioral health clinic. Findings from this study encourage the continued integration of behavioral health services.
Monitoring mechanisms designed to serve persons with intellectual disabilities: exploring the implementation of Article 16 CRPD in Cyprus
Authors: Kakoullis Emily Julia 
Published: June 2018

AbstractIn its concluding observations for Cyprus, the UN Convention on the Rights of Persons with Disabilities (CRPD) Committee stated that it ‘is concerned about the insufficiency of legal provisions and accessible mechanisms to detect, report, prevent and combat all forms of violence’.1This paper focuses on the independent monitoring obligation Article 16(3) CRPD places on states parties, and discusses the implications of the insufficient implementation of Article 16(3) as it affects adults with intellectual disabilities in Cyprus. It examines the existing monitoring frameworks, explains why they do not meet with Article 16(3) CRPD requirements and explores the relationship of the national human rights institutions (NHRIs) with Article 16(3). This paper enables understanding as to how, despite pre-existing monitoring frameworks in place, no independent monitoring action has been taken since the ratification of the CRPD. It argues that there is an immediate need for measures to achieve the implementation of Article 16(3) and makes recommendations for Cyprus and other states parties.
Dayside Magnetospheric and Ionospheric Responses to a Foreshock Transient on 25 June 2008: 2. 2‐D Evolution Based on Dayside Auroral Imaging
Authors: Wang Boyi , Nishimura Yukitoshi , Hietala Heli , Shen Xiao‐Chen , Shi Quanqi , Zhang Hui , Lyons Larry , Zou Ying , Angelopoulos Vassilis , Ebihara Yusuke , Weatherwax Allan 
Published: June 2018

AbstractThe foreshock region involves localized and transient structures such as foreshock cavities and hot flow anomalies due to solar wind‐bow shock interactions, and foreshock transients have been shown to lead to magnetospheric and ionospheric responses. In this paper, the interaction between a foreshock transient and the magnetosphere‐ionosphere system is investigated using dayside aurora imagers revealing structures and propagation in greater detail than previously possible. A foreshock transient was detected by Time History of Events and Macroscale Interactions during Substorms B and C during 1535–1545 UT on 25 June 2008. Time History of Events and Macroscale Interactions during Substorms A, D, and E observed magnetopause compression, cold plasma enhancement, and ultralow frequency waves in the dayside magnetosphere. The all‐sky imager at South Pole observed that both diffuse and discrete aurora brightened locally soon after the appearance of this foreshock transient. The diffuse aurora brightening, which corresponded to a region a few Re size in geocentric solar magnetospheric Y in the equatorial plane, propagated duskward with an average speed of ~100 km/s. Soon after the diffuse aurora brightened, discrete aurora also brightened and extended duskward, which was consistent with the motion of the foreshock transient as it swept through the magnetosheath while impacting the magnetopause. Equivalent horizontal currents measured by magnetometers revealed a pair of field‐aligned currents moving duskward consistent with motion of the discrete aurora patterns. We conclude that the high‐resolution and two‐dimensional observation of auroral responses by ground‐based all‐sky imager can help to estimate the evolution and propagation of upstream foreshock transients and their substantial impacts on the magnetosphere‐ionosphere coupling system, including magnetospheric compression and currents in the ionosphere.
Magnetically Controlled Density Structures in the Martian Ionosphere: Are they Stably Recurring?
Authors: Mohanamanasa P. , Venkateswara Rao N. , Yaswanth Ch. , Rao S. V. B. 
Published: June 2018

AbstractMARSIS instrument aboard the Mars Express spacecraft regularly detects the magnetically controlled density structures (MCDSs) in the Martian ionosphere. In this paper, we studied the recurrence characteristics of these MCDSs using long‐term (more than a decade) MARSIS observations over a selected region of 35° to 40° longitude and −10° to 10° latitude, where a strong magnetic anomaly is present. Instead of a conventional echogram analysis, we used the peak density echogram analysis as the latter is able to consider all the vertical and oblique echoes even if their peak densities are varying. The results of the present study show that MCDSs are in fact formed persistently on all dayside periapsis passes. More importantly, there are discontinuities in the hyperbola shape in a peak density echogram display that appear at different locations on different orbital passes. In addition, the apices of the hyperbolas associated with an MCDS are observed at different latitudes on different orbital passes. From these results, we infer that the locations and shapes of MCDSs are disturbed by some time‐varying external factors so that some parts of the MCDS cannot give specular reflections. These hypotheses were demonstrated with some simple ray propagation simulations. Nearly similar features are observed with the nightside MCDS, but they occur only 60% of the passes. We surmise that wave dynamics associated with tides and gravity waves and so forth might be responsible for altering the shape and location of MCDS, both on the dayside and nightside.