bluuebunny/crossref_metadata_2025_split huggingface dataset:
Intellectual Disability-related genes increase ADHD risk and locomotor activity in Drosophila
Authors: Klein Marieke , Singgih Euginia , van Rens Anne , Demontis Ditte , Børglum Anders D. , Mota Nina Roth , Castells-Nobau Anna , Kiemeney Lambertus A. , Brunner Han G. , Arias-Vasquez Alejandro , Schenck Annette , van der Voet Monique , Franke Barbara 
Published: August 2019

AbstractObjectiveAttention-Deficit/Hyperactivity Disorder (ADHD) is a common, highly heritable neuropsychiatric disorder. ADHD often co-occurs with Intellectual Disability (ID), and shared overlapping genetics have been suggested. This study aimed to identify novel ADHD genes by investigating whether genes carrying rare mutations linked to ID contribute to ADHD risk through common genetic variants. Validation and characterization of candidates were performed using Drosophila melanogaster.MethodCommon genetic variants in a diagnostic gene panel of 396 autosomal ID genes were tested for association with ADHD risk, through gene-set and gene-wide analyses, using ADHD meta-analytic data of the Psychiatric Genomics Consortium (n=19,210) for discovery and iPSYCH ADHD data for replication (n=37,076). The significant genes were functionally validated and characterized in Drosophila by assessing locomotor activity and sleep upon knockdown of those genes in brain circuits.ResultsThe ID gene-set was significantly associated with ADHD risk in the discovery and replication data-sets. The three genes most consistently associated were MEF2C, ST3GAL3, and TRAPPC9. Performing functional characterization of the two evolutionary conserved genes in Drosophila melanogaster, we found their knockdown in dopaminergic (dMEF2) and circadian neurons (dTRAPPC9) to result in increased locomotor activity and reduced sleep, concordant with the human phenotype.ConclusionsThis study reveals that a large set of ID-related genes contributes to ADHD risk through effects of common alleles. Utilizing this continuity, we identified TRAPPC9, MEF2C, and ST3GAL3 as novel ADHD candidate genes. Characterization in Drosophila suggests that TRAPPC9 and MEF2C contribute to ADHD-related behavior through distinct neural substrates.
Single-cell radioluminescence microscopy with two-fold higher sensitivity using dual scintillator configuration
Authors: Kim Tae Jin , Wang Qian , Shelor Mark , Pratx Guillem 
Published: August 2019

AbstractRadioluminescence microscopy (RLM) is an imaging technique that allows quantitative analysis of clinical radiolabeled drugs and probes in single cells. However, the modality suffers from slow data acquisition (10 – 15 minutes), thus critically affecting experiments with short-lived radioactive drugs. To overcome this issue, we suggest an approach that significantly accelerates data collection. Instead of using a single scintillator to image the decay of radioactive molecules, we sandwiched the radiolabeled cells between two scintillators. As proof of concept, we imaged cells labeled with [18F]FDG, a radioactive glucose popularly used in oncology to image tumors. Results show that the double scintillator configuration increases the microscope sensitivity by two-fold, thus reducing the image acquisition time by half to achieve the same result as the single scintillator approach. The experimental results were also compared with Geant4 Monte Carlo simulation to confirm the two-fold increase in sensitivity with only minor degradation in spatial resolution. Overall, these findings suggest that the double scintillator configuration can be used to perform time-sensitive studies such as cell pharmacokinetics or cell uptake of short-lived radiotracers.
In vitroEvaluation of Various Antimicrobials against FieldMycoplasma gallisepticumandMycoplasma synoviaeIsolates in Egypt
Authors: El-Hamid Marwa I Abd , Awad Naglaa FS , Abo-Shama Usama H. , Yousreya MH , Abdel-Rahman Mahmoud A , Hetta Helal F. , Abdelaziz Adel M 
Published: August 2019

AbstractAmong many avian mycoplasmas,Mycoplasma gallisepticum(MG) andMycoplasma synoviae(MS) are recognized as the main etiological agents of respiratory diseases and infectious synovitis in chickens and turkeys causing tremendous economic losses worldwide. Therefore, proper treatment is promoted for the control of these diseases. This study was the first in Egypt to evaluate thein vitroefficacy of various antimicrobials against field MG and MS isolates recovered from chicken and turkey flocks using both conventional microdilution and quantitative real-time PCR (qRT-PCR) assays. Totally, 47 mycoplasma isolates were recovered from 160 collected tracheal samples (29.4%). Of these, 44 MG (27.5%) and 3 MS (1.9%) were identified using conventional and molecular assays. Thein vitrosusceptibilities of 4 representative mycoplasma isolates (3 MG and one MS) to 8 antibiotics and 4 essential oils were investigated. The tested isolates showed various susceptibilities to tested antimicrobials. Toldin CRD, followed by clove, cumin and cinnamon oils were commonly effective against both MG and MS clinical isolates with MIC values ranging from 0.49 to 15.63 µg/mL. Similarly, tylvalosin was the most active antibiotic against MG and MS isolates with the lowest MIC values (0.015-0.03 µg/mL). DNA copies of both MGmgc2and MSvlhAgenes were markedly decreased upon treatment with majority of tested antimicrobials confirming their effectiveness as was also evaluated by conventional MIC results. In conclusion, Toldin CRD and tylvalosin were found to be the most effective antimicrobials in this study, which will contribute in controlling avian mycoplasma infections.Author SummaryAvian mycoplasmosis is considered as one of the most prominent economic problems in the commercial poultry industry worldwide. Antimicrobial therapy is the most effective tool for treatment of mycoplasmas. Owing to the side effects of antibiotics and the development of resistance to the currently used drugs, an increased emphasis on the use of alternative antimicrobials is of utmost importance. Here, we evaluate thein vitroinhibitory effects of some essential oils and various commercial antibiotics againstMycoplasma gallisepticum(MG) andMycoplasma synoviae(MS) field isolates using micro-broth dilution method and qRT-PCR assays. We found that toldin CRD, followed by clove, cumin and cinnamon oils were effective against both MG and MS clinical isolates. Similarly, tylvalosin was the most active antibiotic against MG and MS isolates. We also found that DNA copies of both MGmgc2and MSvlhAgenes were markedly decreased upon treatment with majority of tested antimicrobials. Our study provides new insights into the control of avian mycoplasma infections.
Perceptions and use of cloud in academic activities: a study of a public university in Bangladesh
Authors: Islam Md. Anwarul 
Published: August 2019

Purpose
The purpose of this paper is to explore the initial understanding of what perceptions have the faculty members of Dhaka University and how they use cloud for academic activities.

Design/methodology/approach
A semi-structured questionnaire was used to collect responses from the faculty members of Dhaka University. An online questionnaire was sent out to the faculty members of Dhaka University via e-mail. The questionnaire was both open and close-ended. Overall, 125 respondents participated in this survey and convenience sampling method was used. Mann–Whitney and chi-square test were carried out to see the influence of demographic characteristics on cloud use for teaching and learning activities.

Findings
The results showed that faculty members are generally aware of cloud computing, and they are using some of the cloud applications for teaching and learning purposes. They use cloud for research, collaboration, faculty-students engagement, student supporting activities and sharing course materials. They identified limited wireless access or internet facilities, lack of ICT infrastructure and lack of cloud training and knowledge as major constraints. However, these constraints are mainly related to the poor IT infrastructure and limited access to internet, which may also lead to other constraints.

Originality/value
This is the first time an attempt has been made to explore the perception and use of cloud among the faculty members in a public university, Bangladesh. The findings of this study may shed light to other align research areas of cloud computing in Bangladesh.
Application of the particle finite element method for large deformation consolidation analysis
Authors: Yuan Wei-Hai , Zhang Wei , Dai Beibing , Wang Yuan 
Published: August 2019

Purpose
Large deformation problems are frequently encountered in various fields of geotechnical engineering. The particle finite element method (PFEM) has been proven to be a promising method to solve large deformation problems. This study aims to develop a computational framework for modelling the hydro-mechanical coupled porous media at large deformation based on the PFEM.

Design/methodology/approach
The PFEM is extended by adopting the linear and quadratic triangular elements for pore water pressure and displacements. A six-node triangular element is used for modelling two-dimensional problems instead of the low-order three-node triangular element. Thus, the numerical instability induced by volumetric locking is avoided. The Modified Cam Clay (MCC) model is used to describe the elasto-plastic soil behaviour.

Findings
The proposed approach is used for analysing several consolidation problems. The numerical results have demonstrated that large deformation consolidation problems with the proposed approach can be accomplished without numerical difficulties and loss of accuracy. The coupled PFEM provides a stable and robust numerical tool in solving large deformation consolidation problems. It is demonstrated that the proposed approach is intrinsically stable.

Originality/value
The PFEM is extended to consider large deformation-coupled hydro-mechanical problem. PFEM is enhanced by using a six-node quadratic triangular element for displacement and this is coupled with a four-node quadrilateral element for modelling excess pore pressure.
Credit card cue effect
Authors: Wong King Yin , Lynn Michael 
Published: August 2019

Purpose
The extant literature has mixed results regarding the credit card cue effect. Some showed that credit card cues stimulate spending, whereas others were unable to replicate the findings or found that cues discourage consumer spending. The purpose of this paper is to investigate how consumers’ sensitivity to the pain of payment affects their mental associations about credit cards and how the differences in credit card associations moderate the credit card cue effect on spending, providing a possible explanation for the mixed results in the literature. Furthermore, this paper examines the role of consumers’ perceived financial well-being, measured by their perceptions of current and future wealth and their sense of financial security, in mediating this moderation effect.

Design/methodology/approach
An experimental study was conducted with a sample of 337 participants to test the hypothesized model.

Findings
After being shown credit card cues, spendthrift participants had more spending-related thoughts and less debt-related thoughts, perceived themselves as having better financial well-being and consequently spent more than tightwad participants.

Originality/value
To the authors’ knowledge, this is the first study to investigate the direct link between an exposure to credit card cues and perceived financial well-being, and one of the few to show evidence of the moderating effect of consumers’ sensitivity to the pain of payment on spending when credit card cues are present. This study suggests that marketers may use credit card cues to promote consumer spending, whereas consumers, especially spendthrifts, should be aware of how credit card cues may inflate their perceived financial well-being and stimulate them to spend more.
Factors affecting intention to use e-banking in Jordan
Authors: Anouze Abdel Latef M. , Alamro Ahmed S. 
Published: August 2019

PurposeDespite the wide availability of internet banking, levels of intention to use such facilities remain variable between countries. The purpose of this paper is to focus on e-banking in a country with low intention to use e-banking – Jordan – and to explain the slow uptake.Design/methodology/approachA quantitative method employing a cross-sectional survey was used as an appropriate way of meeting the research objectives. The survey was distributed to bank customers in Amman, Jordan, collecting a total of 328 completed questionnaires. SPSS and AMOS software were used, and multiple regression and artificial neural networks were applied to determine the relative impact and importance of e-banking predictors.FindingsThe statistical techniques revealed that several major factors, including perceived ease of use, perceived usefulness, security and reasonable price, stand out as the barriers to intention to use e-banking services in Jordan.Originality/valueThis study theorizes a series of implications on intention to use e-banking. It draws the attention of Jordanian banks to the full functionality of their e-banking systems, emphasizing positive safety features, which could contribute to changing negative customer perceptions. It also contributes to eliciting the theory of customer value among banks by focusing on how they should properly enhance their use of shared value. Moreover, it will present to managers how e-banking predictors can send meaningful and timely information to customers.
CSR marketing outcomes and branch managers’ perceptions of CSR
Authors: Moliner Miguel Angel , Monferrer Tirado Diego , Estrada-Guillén Marta 
Published: August 2019

PurposeThe purpose of this paper is to analyze the role of bank branch managers’ perceptions of corporate social responsibility (CSR) in CSR marketing outcomes.Design/methodology/approachThe paper proposes a causal model establishing that managers’ perceptions of CSR influence the perception of CSR held by the branch’s customers, which in turn directly affects customer satisfaction, customer trust, customer engagement and customer loyalty. The unit of analysis in this quantitative study is the bank branch. Two questionnaires were administered: one to branch managers and another to five customers in each branch.FindingsBranch managers’ perceptions of CSR have a marked influence on customers’ perceptions of CSR, which again have a notable impact on the relationship variables studied: customer satisfaction, customer trust, customer engagement and customer loyalty.Research limitations/implicationsThe sample was taken from two banks in the same country (Spain) and only five customers were interviewed in each branch. The type of customers analyzed should be taken into account since a growing number of customers now carry out all of their banking online and are less likely to visit their branch.Practical implicationsThe results highlight the importance of adopting socially responsible actions not only in the bank as a whole, but also in individual branches. It would, therefore, seem crucial for high level bank executives not only to involve branch managers in the bank’s CSR strategy, but also to empower them to undertake CSR actions that involve the customers and local community with which they interact.Originality/valueFirst, the paper reveals the differences within the same organization in the way its CSR strategy is implemented. Second, intermediary figures or supervisors are shown to have a key role in ensuring the organization’s CSR strategy is effective. Third, the study emphasizes the importance of customers’ perception of CSR in achieving the main outcomes of relationship marketing (satisfaction, trust, engagement and loyalty). Fourth, the methodology applied in the study is innovative in its construction of dyads in which the branch is the unit of analysis, enabling a comparison between the manager’s perceptions of CSR with that of five customers from the same branch. Fifth, the findings add to the knowledge of a particularly relevant sector in the recent economic crisis, namely, the retail banking industry.
Applying multivariate linear regression and multi-layer perceptron artificial neural network to design an energy consumption baseline in a low density polyethylene plant
Authors: Hamedi Behnam , Mokhtar Alireza 
Published: August 2019

PurposeThe purpose of this study is to investigate and analysis of energy consumption for this industry. The core part of any energy management system (EnMS) in industry is to perfectly monitor the energy consumption of significant users and to continuously improve the energy performance. In petrochemical plants, production deals with energy-intensive processes, and measuring energy performance for recognition and assessment of potentials for saving is critical.Design/methodology/approachThe required data are exploited for the period of March 2011-August 2016 (data set: 2,012 days). Multivariate linear regression (MLR) and multi-layer perceptron artificial neural network (ANN) methods are separately used to anticipate the energy consumption. The baseline will be assumed as a reference to be compared with the actual data to estimate the real saving values. Finally, cumulative summations (CUSUM) are proposed and applied as an effective indicator for measurement of energy performance in an LDPE.FindingsIn this study, two statistical methods of MLR and ANN were used to design and develop a comprehensive energy baseline representing the predicted amounts of energy consumption based on the recognized drivers. Although both models imply robust outcomes, when the relative errors are taken into account, performance of ANN models appears fairly superior compared to the MLR model.Originality/valueIt is highly suggested to the ISO technical committee dealing with energy management standards, to consider the proposed model for baseline development in the future version of the standard ISO 50006 as the supplementary extension for the ISO 50001 for measuring energy performance using EnB and EnPI. As for future studies, the research can be extended to investigate the uncertainty and the model could also become completed applying more advanced ANNs such as recurrent neural networks.
Are higher education institutions in Europe preparing students for IPSAS?
Authors: Adam Berit , Brusca Isabel , Caperchione Eugenio , Heiling Jens , Jorge Susana Margarida F. , Manes Rossi Francesca 
Published: August 2019

PurposeThe purpose of this paper is to analyze whether higher education institutions (HEIs) in EU Member States are aware of the relevance of the ongoing reforms in public sector accounting (PSA) and the need to prepare their students to become expert professionals in that area. It particularly assesses whether these organizations currently provide, or will provide in the near future, education on International Public Sector Accounting Standard (IPSAS)/EPSAS, so that a sufficient number of graduates will be ready to match the foreseeable demand for experts in IPSAS/EPSAS.Design/methodology/approachAdopting a purposive sample, the paper compares the situation in four EU countries (Germany, Italy, Portugal and Spain). Data have been obtained through a questionnaire provided to selected professors in relevant HEIs in the selected countries.FindingsHEIs are giving only limited room to PSA and financial management, with differences in terms of program offerings and coverage of topics among the four countries. Furthermore, in most cases, the programs are adapted to the national budgetary and accounting standards and courses are seldom focused on the IPSASs.Originality/valueThe paper contributes to the literature on PSA harmonization, through an innovative analysis of PSA and financial management teaching, both at national and international levels.
Biomimetics for business? Industry perceptions and patent application
Authors: Kohsaka Ryo , Fujihira Yoshinori , Uchiyama Yuta 
Published: August 2019

PurposeBiomimetics are expected to contribute to sustainable environmental management; however, there has been no exploration of industry perceptions by using empirical data. This study aims to identify the trends and perceptions of biomimetics. The industrial sectors in Japan and international patent application trends are analyzed.Design/methodology/approachAn online survey to identify the perceptions of staff members in Japanese private companies (n = 276) was conducted. Japan is an emerging country in terms of the social implementation of biomimetics, and this paper can provide insights into other such countries.FindingsIt is identified that the strength of connections to biomimetics differs across industrial sectors. The respondents from companies that use nanoscale biomimetics tend to have the knowledge of, and experience in, biomimetics. Regarding the overall understanding of patent applications, Japanese private company employees require knowledge of patent application trends and country rankings as potential factors influencing the development of biomimetics.Social implicationsKnowledge transfer and sharing of experience among engineers and researchers of nanoscale technologies and urban scales are necessary to facilitate biomimetic advancement.Originality/valueThe results of the first survey and an analysis of the perceptions of staff members in private companies in Japan are provided to show the challenges in the social implementation of biomimetics. The results can be referred to for the social implementation of biomimetics in emerging countries. The method of this study can be applied to an international comparative analysis in future research.
Rural community well-being through minor league sport
Authors: Kim Young Do , Magnusen Marshall J. , Weaver Anthony , Kim Minjung 
Published: August 2019

PurposeThe purpose of this paper is to investigate how small-town residents’ perceptions of a minor league sport team’s socially responsible initiatives (SRI) influence several psychological responses to SRI, including feelings of gratitude, subjective well-being, place attachment and community pride.Design/methodology/approachA cross-sectional, survey-based research design was employed to empirically assess the effects of SRI on positive psychological responses in the context of a minor league sport team located in a rural community. The data set used in this study included a convenience sample of 307 small-town residents.FindingsResidents of the rural community did perceive and feel grateful for their minor league sport team’s SRI. Grateful residents experienced higher levels of subjective well-being (happiness, pleasure and satisfaction) as well as enhanced community pride and attachment due to the local sport team’s altruistic and prosocial behaviors.Research limitations/implicationsThis study’s findings shed light on a critical function and benefit of a minor league sport team in rural communities. Emotionally valued prosocial efforts enhance the well-being of residents in rural communities. Thus, a reasonable course of action for local community leaders and public-sector organizations is to invest in and create partnership opportunities with their local minor league sport teams. Such efforts can turn sport teams into leverageable assets that can help promote healthy and sustainable communities for current residents as well as future generations.Originality/valueA contribution of this study is the integration of the broaden-and-build theory of positive emotions to better understand how gratitude mediates the relationship between SRI and beneficial community-focused outcomes such as pride, attachment and well-being.