bluuebunny/crossref_metadata_2025_split huggingface dataset:
(252) IMPACT OF SUBINGUINAL MICROSURGICAL VARICOCELECTOMY ON MALE INFERTILITY: FEMALE AGE, SEMINAL PARAMETERS, SERUM TESTOSTERONE AND PREGNANCY RATE - RETROSPECTIVE COHORT AT A UNIVERSITY HOSPITAL IN RIO DE JANEIRO
Authors: Moreira Crelier G , Oliveira Da Rosa K , Carvalho Menezes M , De Teófilo E Figueiredo Filho R , Mario Costa Lara C , Luiz Schiavini J , Vinícius Oliveira Vasconcelos C , Ribeiro Júlio Junior H , Damião R 
Published: December 2024

Abstract

Introduction
Varicocele is the most common identifiable cause of male infertility, and varicocelectomy is the most commonly performed surgery for its treatment. This condition has an impact on infertility cases and sperm quality. Microscopic varicocelectomy is the gold standard treatment for varicocele because it allows preservation of the testicular artery and lymphatic vessels, ligament of the spermatic veins, and a significant reduction in complications. This retrospective cohort aims to evaluate the effects of microscopic varicocelectomy on seminal parameters, serum testosterone, and pregnancy rate in the context of male infertility in 39 patients operated on at a university hospital in Rio de Janeiro.

Objective
This retrospective cohort aims to evaluate the effects of microscopic varicocelectomy on seminal parameters, serum testosterone, and pregnancy rate in the context of male infertility in 39 patients operated on at a university hospital in Rio de Janeiro.

Methods
This study is a retrospective cohort conducted between January 2016 and February 2023, based on 39 men who underwent subinguinal microscopic varicocele repair in the context of conjugal infertility. Pre- and post-operative analyses of seminal parameters were based on the criteria of the World Health Organization from 2010. Post-operative semen analysis and serum testosterone were performed 3 to 6 months after varicocelectomy. The pregnancy rate was observed through interviews until February 28, 2023.

Results
Subinguinal microscopic varicocelectomy is associated with a significant increase in testosterone levels and an improvement in semen parameters, all with statistical significance. Testosterone showed an average increase of 84.2 (±14.7) ng/dL. The average age of the partners was 34 (22-42) years. The pregnancy rate also increased significantly, with 51.3% of couples achieving pregnancy at the time of this study.

Conclusions
In this cohort, infertile men with clinical varicocele who underwent subinguinal microscopic varicocelectomy showed a significant increase in testosterone levels, improvement in semen parameters, and a significant reduction in the proportion of azoospermia. The female factor is presumed to have influenced the lower fertility rates observed within the studied group. Additionally, there was an increase in the occurrence of pregnancy in couples with conjugal infertility.

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(259) ASSESSMENT OF THE IMPACT OF SURGICAL CORRECTION ON THE SEXUAL FUNCTION OF MEN WITH PEYRONIE’S DISEASE
Authors: Borges Cabral Junior J , Mikaelly Da Silva Gomes V , Antônio De Souza Filho C , Augusto Irineu Aguiar Ramos L , Ariel Pires Cavalcanti Zeca A , De Albuquerque Pereira De Oliveira R , Conceição De Souza R , Henrique Sales Lins T , Jose Cardoso Cavalcante F 
Published: December 2024

Abstract

Introduction
Peyronie’s disease is an acquired condition characterized by the formation of fibrotic plaques in the penis, resulting in curvature that can cause pain during erections and affect penetration ability. Surgical correction is indicated when conservative treatment fails and sexual activity is compromised, impacting the patient’s quality of life and sexual satisfaction. Sexual intercourse problems can lead to emotional distress, social isolation, and affect the relationship with the partner, ultimately impacting the sexual function of these patients.

Objective
Evaluate the effect of surgical correction of Peyronie’s disease on male sexual function.

Methods
A prospective study was conducted on patients undergoing Peyronie’s correction surgery at a tertiary hospital in northeastern Brazil in 2023. Patients completed the International Index of Erectile Function (IIEF-5) before and 6 months after procedure, evaluating erectile dysfunction (ED) and satisfaction with intercourse. ED severity was categorized based on scores: severe (1-7), moderate (8-16), and mild (17-21).

Results
Five patients underwent surgery, with four completing six-month follow-up. Mean age was 43 years (range: 25-57). Intraoperative penile curvature averaged 60 degrees, with 50% presenting dorsal curvature. Fifty percent reported residual curvature, yet all noted subjective improvement in sexual satisfaction post-surgery. Postoperative penetrative ability was 100%. Preoperatively, 50% had severe ED, 25% moderate, and 25% mild. Postoperatively, 50% had no ED, and 50% had mild dysfunction. Techniques included Yachia’s (25%), Nesbit’s plication (50%), and bovine pericardial graft (25%). Half had a history of penile fracture. Curvature degree did not determine postoperative dysfunction persistence. Patients with mild ED were older and had comorbidities. No deaths or increased morbidity occurred post-surgery.

Conclusions
The results show that surgical correction of Peyronie’s disease is safe and enhances patient function and sexual satisfaction, promoting improved quality of life post-procedure.

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(262) CORRELATION OF PENILE GRAYSCALE PHARMACO-ULTRASONOGRAPHY WITH ERECTILE TISSUE COMPOSITION IN MEN WITH ERECTILE DYSFUNCTION
Authors: Kim NN , Goldstein SW , Goldstein I 
Published: December 2024

Abstract

Introduction
Percentage of corporal smooth muscle and corporal connective tissue within penile erectile tissue was determined by histomorphometric assessment of biopsies removed during penile prosthesis insertion. Previous studies have shown that these histomorphometry data correlated with pre-operative pharmacocavernosometry testing during complete smooth muscle relaxation. At 50-55% corporal connective tissue (CCT) content, corporal veno-occlusive function was found to be normal. When CCT content was 60-75%, corporal veno-occlusive function significantly worsened in an exponential relationship. Above 75% CCT content, there was no recordable corporal veno-occlusive function. Pre-operative grayscale ultrasonography (GUS) during complete smooth muscle relaxation is a less invasive in-office diagnostic assessment for ED than pharmacocavernosometry. It has been previously reported that hypoechoic areas in GUS are indicative of regions of erectile tissue fibrosis.

Objective
We examined for the first time whether findings on pre-operative GUS could correlate with histomorphometry data on CCT content in the same manner that pharmacocavernosometry correlated with CCT content.

Methods
Pre-operative proximal shaft axial plane GUS images were obtained using a 15.4 MHz probe (Aixplorer), gain setting 45%, dynamic range 70 dB. Percent hypoechoic area within the corporal cavernosa was assessed by computer-assisted image analysis using Image J (Fig. 1). During penile prosthesis surgery, erectile tissue from the proximal shaft was biopsied for histological analysis (n = 12). Formalin-fixed (10%), paraffin-embedded tissue sections (5 μm) were stained with Masson’s trichrome. Photomicrographs were analyzed by Image J using the Masson trichrome vector of the color deconvolution plugin.

Results
Percent hypoechoic area was poorly correlated to percent CCT area by linear regression analysis (r2 = 0.287). However, a non-linear regression model, an exponential growth curve, provided a better fit (r2 = 0.672) with an inflection point at 40% CCT area (Fig. 2). The abrupt shift is similar to the previously reported corporal veno-occlusive function curve using pharmacocavernosometry.

Conclusions
Estimation of percent hypoechoic area on pre-operative GUS images during complete smooth muscle relaxation may be a useful, non-invasive assessment of CCT content to predict corporal veno-occlusive function. Larger cohorts of ED patients are needed to verify the clinical utility of GUS.

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(286) ASSESSMENT OF THE SITUATION REGARDING THE HEALTH OF TRANSGENDER PEOPLE IN HEALTHCARE IN POLAND. RETRANSITION OF TRANSGENDER PEOPLE. KNOWLEDGE AND OPINION OF TRANSGENDER PEOPLE ON REPRODUCTIVE HEALTH AND CANCER PREVENTION
Authors: Zborowska K , Jorg D , Chrapkiewicz B , Krzysztofik S 
Published: December 2024

Abstract

Introduction
As a result of negative and traumatic experiences of transgender people related to access to health care in Poland, many of them give up necessary health care services and emphasize their willingness to retransition. Due to the lack of procedures in this area, these people express a negative attitude towards medical and psychological care.

Objectives
The aim of the work is to assess the health care system in Poland in the field of reproductive health, cancer prevention and the retransition process of transgender people.

Methods
Transgender people in Poland were included in the study. 140 transgender people were examined, including 80 transgender men (in.20 retransition) and 60 transgender women. The study used an original questionnaire to examine knowledge and opinion, as well as standardized questionnaires assessing the quality of life and self-esteem.

Results
The study showed that transgender people have very average knowledge of reproductive health prevention. Knowledge in the field of cancer prevention is very low. In the field of reproductive health care, they show no interest due to the lack of support from the health system in Poland and due to their own socioeconomic conditions. Additionally, in terms of opinions, they point to the lack of knowledge in this area on the part of medical staff. The care of transsexual people in Poland is based mainly on diagnosis and implementation of the treatment process in the field of transition, as well as professional psychological care in which the topic of reproductive health is discussed. In the field of medical care - gynecological aspects of reproductive health in terms of protection of reproductive cells or exposure to hormonal treatment in the field of anticancer prevention, no screening tests have been introduced. In Poland, there are no guidelines regarding the retransition process. Transgender people are deprived of professional care.

Conclusion
In order to ensure professional health care and a safe and friendly environment for transgender people in Poland, it is recommended to train medical staff in the field of cultural competence.

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(288) PATIENT-REPORTED PAIN DURING HYALURONIC ACID PENILE GIRTH ENHANCEMENT PROCEDURES: A CROSS-SECTIONAL STUDY
Authors: Gutierrez Claure LA , Cavalcanti Filho MT , Lemos C , Lattanzi C , Rodrigues D , Ramalho G , Monteiro L 
Published: December 2024

Abstract

Introduction
Penile girth enhancement is a procedure sought by men aiming to increase penile circumference. However, concerns about pain often deter patients from undergoing the procedure, as it is perceived to be painful.

Objective
The objective of this study is to quantify the pain experienced during the penile girth enhancement procedure with hyaluronic acid.

Methods
A cross-sectional, single-center study included men who sought private care to realize penile girth enhancement from March to June 2024. During the procedure, patients reported pain using the Visual Analogue Scale, a multidimensional tool that assesses pain intensity, providing a comprehensive pain profile for effective clinical management (variable 0-10, 0 = no pain, 5 = moderate pain and 10 = worst pain). All statistical and graphical analyses were performed using RStudio.

Results
We evaluated 128 men. The patients have an average age of 44.46 years (23-77). All patients have the chief complaint of the penile circumference. The VAS minimum 0, first quartile 1.0, median 2.0, mean 1.9, maximum 5.0 and third quartile 2.0. The percentage distribution across VAS has 0 = 0.8%, 1 = 25.8%, 2 = 57.0%, 3 = 8.6%, 4 = 6.2%, 5 = 1.6%. None of the patients related pain 6 to 10.

Conclusions
In this pilot study, our findings suggest that the penile girth enhancement procedure with hyaluronic acid is associated with minimal pain levels (98,4%). This indicates that the procedure is well-tolerated and presents a viable option for men seeking penile girth enhancement with manageable pain levels.

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(292) THE ROLE OF PRE-SYNAPTIC β1-ADRENOCEPTORS IN RAT ISOLATED EPIDIDYMAL VAS DEFERENS CONTRACTILITY
Authors: Oliveira DL , Rios Campitelli R , Britto Júnior J , Tiago Lima A , Fregonesi A , Antunes E , De Nucci G 
Published: December 2024

Abstract

Introduction
The absence of a low-affinity site for propranolol after reserpinisation or rauwolscine treatment suggests a dependence on intact catecholamine stores and α2-adrenoceptors, reflecting β-blockers’ action. In guinea-pig vas deferens, β-adrenoceptor activation increases noradrenaline release while decrease ATP release. Isoprenaline reduces nerve-induced responses in rat vas deferens.

Objective
To investigate the effect of presynaptic beta 1 adrenergic agonists in rat vas deferens.

Methods
Adult male Wistar rats were euthanized with isoflurane, then epididymal vas deferens were isolated, placed in Krebs–Henseleit’s solution, and mounted in tissue baths for isometric tension recording using a PowerLab system. The effect of β-adrenoceptor agonist RO363 (100 nM), and antagonists betaxolol (1 μM), metoprolol (1 μM), and atenolol (1 μM) on adrenaline (ADR), noradrenaline (NA) and dopamine (DA) induced contractile responses was assessed. Electric-field stimulation (EFS) and the effect of the sodium channel antagonist tetrodotoxin (TTX 1 μM) were also evaluated. All the procedures were approved by an Ethic Committee. Data were analyzed using nonlinear regression to determine pEC50 values and expressed as mean ± SEM.

Results
The data showed that RO363 had no effect on DA but caused a concentration-dependent leftward shift on the NA and ADR curves, abolished by TTX pretreatment. RO363 enhanced tissue contraction in response to EFS across all frequencies. Atenolol, betaxolol and metoprolol abolished the effect of RO363 on NA and ADR curves.

Conclusions
Findings reveal that the β1-adrenoceptor agonist RO363 selectively modulates contractile responses to NA and ADR, indicating a specific interaction with these neurotransmitters sensitive to sodium channel blockade by TTX. The abolition of RO363’s effect by β1-adrenoceptor antagonists further underscores the specificity of β1-adrenoceptor involvement. Results suggest that β1-adrenoceptors are crucial in regulating neurotransmitter-induced contractility in the vas deferens, potentially through mechanisms dependent on intact catecholamine stores and α2-adrenoceptors. This study enhances understanding of adrenergic modulation in male reproductive physiology and may inform future research on pharmacological manipulation of vas deferens contractility.

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(298) HYALURONIC ACID FOR PENILE GIRTH ENHANCEMENT: BRAZILIAN EXPERIENCE
Authors: Cavalcanti Filho M , Rodrigues D , Gutierrez Claure L , Lattanzi C , Lemos C , Fernandes G , Monteiro L 
Published: December 2024

Abstract

Introduction
In recent years aesthetic injection techniques with soft tissue fillers have become popular worldwide due to their effectiveness and safety. Penile girth enhancement is a significant aspiration for many men and is considered to symbolize masculinity and sexual prowess. Furthermore, according to the literature, girth appears to be more important for sexual satisfaction.

Objective
To demonstrate the penile girth pre and post the application of hyaluronic acid.

Methods
A retrospective, single-center study included men who sought private care to realize penile girth enhancement from March to June 2024. All patients signed an informed consent form. Excluded men with dysmorphophobia, active inflammatory-infectious genital lesion, and prior application of another filler. Penile girth was measured with a tape measure at baseline and follow-up appointment.

Results
103 patients were included in this analysis. The male participants had an average age of 45.0 ± 10.2 (26-77) years. The average stretched penile length (SPL) was 14.0 ± 1.9 cm, the initial circumference was 10.0 ± 1.3 cm. Mean injected volume was 8.1 ± 1.6 ml and the final average circumference was 11.3 ± 1.3 cm, the average difference in circumference was 1.5 ± 2.2 cm. The follow-up appointment mean was 22 days. Compared a mean with a basal girth and after 1 application the Test t result was significant p &lt; 0.001. There was no association in the linear regression between the post circumference and amount injected (R2 = 0.01, p = 0.304) and in the difference before/after and amount injected (R2 = −0.01, p = 0.466). There were no inflammatory signs or serious adverse reactions in all cases, and no patient requested a reversal of the procedure.

Conclusions
Our study suggests that Hyaluronic acid injections is an effective option for men desiring non-surgical enhancement, with an average girth increase of 1.5 cm. Further research is needed as the procedure can be sequential, with several sessions generating gains in circumference with each session.

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(306) SEXUALITY OF YOUNG WOMEN WITH CERVICAL CANCER. DOES HEALTH CARE IN POLAND PROVIDE SUPPORT FOR PSYCHOSEXUAL TREATMENT OF WOMEN WITH CERVICAL CANCER?
Authors: Zborowska K , Chrapkiewicz B 
Published: December 2024

Abstract

Introduction
Every year, approximately 2.5 thousand people are diagnosed with cervical cancer. Polish women, of whom approximately 1.6 thousand die. Currently, cervical cancer is the seventh cause of cancer deaths among women in Poland, and current statistics alarm that this disease increasingly affects young and professionally active women.

Objective
The aim of the study was to assess sexual activity and effective support in the field of sexological care in women of reproductive age diagnosed with cervical cancer.

Methods
The study involved 30 women aged 22 to 35 who were diagnosed with cervical cancer. The patients underwent long-term care from the moment of cancer diagnosis until recovery for a period of one year. The study identified the cause of the cancer - HPV virus in 80%, verified the quality of life of the MSEI, the assessment of the STAI drug and the sexual functioning of the FSFI, as well as an original questionnaire that verified the opinion in the field of medical and sexological-psychological care provided.

Results
The study showed that women who received sexological and psychological care achieved higher indicators in terms of quality of life (p = 0.000) and in terms of engaging in sexual activity (p = 0.001) and higher sexual satisfaction (p = 0.000). The study also showed a very high level of dissatisfaction with the state medical care in the field of psychological and sexological services and showed that patients did not know about HPV infection in the field of cervical cancer prevention. All patients were not vaccinated against HPV and there were stereotypes in this regard among their beliefs.

Conclusions
Cervical cancer is directly related to persistent infection with the human papillomavirus (HPV), which requires the introduction of appropriate support and preventive measures among young women in terms of vaccination and vaccination of the appropriate preventive group. In Poland, there is a very big problem in vaccinating young women suffering from cervical cancer.

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(310) MSM ARE NOT SMALLER THAN HETEROSEXUAL MEN AND HAVE LONGER PENISES THAN STRAIGHT MEN. THE TBORNOTTB STUDY: 8755 MSM
Authors: Herrero R , Bourmaud A , Boizeau P , Ohayon M 
Published: December 2024

Abstract

Introduction
Research regarding the anal penetrative roles in men who have sex with men (MSM) is still in its infancy. Studies have aimed to determine the frequencies of anal positioning in MSM but have arrived at contradictory results. Studies researching the effects of physical characteristics (PC) on anal positioning are scarce. Some studies have found that gay men were shorter than heterosexual men, but others have found the opposite. PC are important as they have been shown to affect sexual behavior and because differences in PC may suggest sexual orientation and anal penetrative orientation may have, in part, a biological foundation.

Objective
Sexual anal positioning amongst MSM is central to the understanding of this population, with important repercussions on the sexological and physical fulfillment of these individuals. The purpose of our study was to determine the real frequencies of the anal positions frequently referred to as “bottom,” “top,” “versatile,” and “side,” and to determine the factors that might participate in the conclusion of sexual negotiations. We present here some PC of MSM related to anal sexual positioning. Previous research studying PC in men have found gay men to be smaller than heterosexual men. We do not find this to be the case.

Methods
An on-line anonymous questionnaire was made available in the French language to all cisgender MSM of at least 18 years of age between June 25, 2020 and October 26, 2020 on the subject of anal positioning. The questionnaire presented 104 questions, with a total of 190 items being evaluated. Data is declarative and results are descriptive.

Results
9734 people clicked on our questionnaire. 8755 people met all the inclusion criteria for statistical analysis. Mean height of respondents was 178 cm (SD = 7.0) and mean weight was 76 kg (SD = 13) [mean BMI = 24.0 kg/m2]. For anal identity, 40.8% declared to be “bottom,” 30.8% “versatile,” 24.0% “top,” and 2.9% “side” (nonpenetrative). Among MSM, “tops” and “versatile” men were taller in height than “bottoms” (p &lt; .0001). The median erectile penile length of the respondents in our study was 17.0 cm (mean = 16.9; SD = 2.2), with “tops” and “versatiles” having a longer erect penis than “bottoms” (p &lt; .0001).

Conclusions
TBornotTB is the largest study to date on anal sexual positioning amongst MSM. The most common anal identity is “bottom.” The height of the MSM in our study is above the average height of men in France and its neighboring countries. Erect penis length is larger in MSM than in the general population. Most MSM do not vary their positioning according to a partner’s physical characteristics, although for a good proportion these can be determinant. Our study confirms that penis size and beautiful buttocks are significantly related to sexual positioning.

Disclosure
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