bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cancer-associated Fibroblasts (CAFs) Regulate Lung Cancer Malignant Progression by Transferring SERPINE2 (PN1) Via Exosomes
Authors: Chen Yu , Zhu Sihong , Yang Ling , Lu YuFen , Ye Xiaoqun 
Published: October 2024

Background and Aim:
Cancer-associated fibroblasts (CAFs), one of the
most abundant stromal cell types in the tumor microenvironment (TME), are potential
targets for cancer treatments such as lung cancer. However, the underlying
mechanism by which CAFs promote lung cancer progression remains elusive.

Methods:
We obtained primary CAFs, normal fibroblasts (NFs), and their exosomes
and constructed protease nexin-1 (PN1) stably silenced or over-expressed CAFs cells
using lentivirus. Bioinformatics was used to obtain the expression of PN1 in lung
cancer and normal tissues, the relationship with overall survival, and the enriched
pathways. The MTT and Transwell assays were performed to detect the proliferation,
migration, and invasion abilities of lung cancer cells after treatment. Western blotting,
qRT-PCR, immunohistochemistry, and xenograft models were used to illustrate the
role of CAFs in lung cancer progression via exosomes.

Results:
CAFs-derived exosomes, in which PN1 was more highly expressed than that
in NFs-derived ones, effectively promoted the proliferation, migration, and invasion
potentials of lung cancer cells A549 and H1975. Meanwhile, the PN1 expression was
higher in lung cancer tissues than that in normal tissues and was negatively
associated with the overall survival rate of lung cancer patients. More importantly,
over-expressing or silencing of PN1 in A549 and H1975 cells promoted or inhibited cell
proliferation, migration, and invasion, correspondingly. Furthermore, treated with PN1
overexpressing CAFs-derived exosomes, the lung cancer cells proliferation, migration,
and invasion varied positively and were accompanied by activation of Toll-like and NF-
κB signaling pathways. However, this phenomenon can be reversed by AN-3485, an
antagonist of the Toll-like pathway. Finally, overexpression of PN1 leads to
accelerated tumor growth by increasing the expression of the proliferation biomarker
Ki67 and activation of the NF-κB signaling pathway in vivo.

Conclusion:
CAFs promoted lung cancer progression by transferring PN1 and
activating the Toll-like/NF-κB signaling pathway via exosomes.
In Vitro Antibacterial Activity of Adiantum capillus Veneris Extraction with Methanol, Chloroform, and Ether Solvents against Methicillin-resistant Staphylococcus aureus
Authors: Ebrahimzadeh Mahdiyeh , Rahbari Solmaz , Doust Reza Hosseini , Mojab Faraz 
Published: October 2024

Background:
The increasing problem of multi-drug resistant (MDR) pathogens is a worldwide
concern, especially in the pharmaceutical industry. At the same time, medicinal plants have
renewed interest because of their wide variety of bioactive phytochemicals, which could be used to
develop new antimicrobial drugs. This renewed interest is partly due to the growing resistance to
traditional drugs and their associated side effects.

Methods:
The objective of this study is to assess the antimicrobial properties of the total extract and
various fractions of Adiantum capillus veneris against Methicillin-resistant Staphylococcus aureus
(MRSA). The aerial parts of Adiantum capillus veneris were subjected to extraction using methanol,
chloroform, and ether, and the resulting extracts were tested for their antimicrobial activity against
MRSA. Additionally, essential oil was obtained from the aerial parts using a Clevenger apparatus
and boiling water. Furthermore, Gas Chromatography-Mass Spectrometry (GC/MS) was utilized to
analyze the phytochemicals isolated from the extracts of Adiantum capillus veneris.

Results:
The essential oil was obtained through distillation and then analyzed using GC/MS. The
antimicrobial activity was evaluated using the agar diffusion method.

Conclusion:
GC/MS analysis revealed that the composition was primarily phytol (59.9%), constituting
99.3% of phyto-constituents. However, both the total extract and the individual fractions exhibited
no inhibitory effects against MRSA strains
Experiences of Patients With Cancer Using Electronic Symptom Management Systems: Qualitative Systematic Review and Meta-Synthesis
Authors: Zhu Siying , Dong Yan , Li Yumei , Wang Hong , Jiang Xue , Guo Mingen , Fan Tiantian , Song Yalan , Zhou Ying , Han Yuan 
Published: October 2024

Background
There are numerous symptoms related to cancer and its treatments that can affect the psychosomatic health and quality of life of patients with cancer. The use of electronic symptom management systems (ESMSs) can help patients with cancer monitor and manage their symptoms effectively, improving their health-related outcomes. However, patients’ adhesion to ESMSs decreases over time, and little is known about their real experiences with them. Therefore, it is necessary to gain a deep understanding of patients’ experiences with ESMSs.

Objective
The purpose of this systematic review was to synthesize qualitative studies on the experiences of patients with cancer using ESMSs.

Methods
A total of 12 electronic databases, including PubMed, Web of Science, Cochrane Library, EBSCOhost, Embase, PsycINFO, ProQuest, Scopus, Wanfang database, CNKI, CBM, and VIP, were searched to collect relevant studies from the earliest available record until January 2, 2024. Qualitative and mixed methods studies published in English or Chinese were included. The PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement checklist) and the ENTREQ (Enhancing Transparency in Reporting the Synthesis of Qualitative Research) statement were used to improve transparency in reporting the synthesis of the qualitative research. The Critical Appraisal Skills Program (CASP) checklist was used to appraise the methodological quality of the included studies, and a meta-synthesis was conducted to interpret and synthesize the findings.

Results
A total of 21 studies were included in the meta-synthesis. The experiences of patients with cancer using ESMSs were summarized into three major categories: (1) perceptions and attitudes toward ESMSs; (2) the value of ESMSs; and (3) barriers, requirements, and suggestions for ESMSs. Subsequently, 10 subcategories emerged from the 3 major categories. The meta-synthesis revealed that patients with cancer had both positive and negative experiences with ESMSs. In general, patients recognized the value of ESMSs in symptom assessment and management and were willing to use them, but they still encountered barriers and wanted them to be improved.

Conclusions
This systematic review provides implications for developing future ESMSs that improve health-related outcomes for patients with cancer. Future research should focus on strengthening electronic equipment and technical support for ESMSs, improving their functional contents and participation forms, and developing personalized applications tailored to the specific needs and characteristics of patients with cancer.

Trial Registration
PROSPERO CRD42023421730; https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=421730
Evaluation and Improvement of Oncologists' Adherence to NCCN Guideline for Prevent and Treatment of Cancer Associated Venous Thromboembolism
Authors: Naeemah Ghufran Hassoun , AL. Ameen Ayad Ali Hussein 
Published: October 2024

Objective: the aim of this study is asses the adherence of physician to NCCN guideline recommended anticoagulant therapy in patient with cancer associated venous thromboembolism.
Method: study was designed with two phases an observational phase and an interventional prospective phase with the educational program, was conducted at Middle Euphrates cancer center /An-Najaf governorate/Iraq. Ten oncologists who agreed to participate in the study. Used validated questionnaire include (25 items) where distributed to 10 oncologists who were working at the Middle Euphrates cancer center then all questionnaires were collected from participated oncologists over two months. Subsequently, an educational part including a lecture and posters was submitted in cancer center to in raising awareness of seriousness of this disease and how prevention and treatment.
Results: The overall mean total score of oncologists for prevention and management of cancer associated VTE (out of 25 items) of all questionnaire parts was remarkably increased from (0.54) to (0.72) after the intervention therefore the level of oncologist's adherence to NCCN guideline improved to 70% with large effect size (1.04).
Conclusion: According to the final evaluation of responses of oncologists showed improvement in adherence toward the NCCN guideline. In addition, there were several barriers that mainly reduce the adherence like sever side effect, increase cost and Lack of awareness of guidelines.
Compensation for Losses in Latvian Groups of Companies Law
Authors: Balodis Kaspars 
Published: October 2024

The main purpose of the legal regulation of groups of companies, i.e. the Groups of Companies Law of Latvia, is to protect rights and legitimate interests of the dependent company, its creditors and minority shareholders. A controlling enterprise is entitled to pursue its own economic interests by exerting the decisive influence on a dependent company. There is no general prohibition for a controlling enterprise to induce the dependent company into entering transactions or carrying out measures that are disadvantageous to the dependent company. Disadvantageous transactions have to be reflected in the yearly dependency report submitted by the board of the dependent company. As a general principle, the controlling enterprise shall compensate the dependent company for losses arising from disadvantageous transactions or undertakings. If a group contract between the controlling enterprise and the dependent company exists, legal representatives (board members) of the controlling company are jointly responsible for the losses of the dependent company. If a group contract has not been concluded and a de facto group of companies exists, the controlling enterprise itself has to compensate for the losses of the dependent company. Besides the controlling enterprise, the legal representatives of this enterprise are jointly responsible.
Experience of Reforms to the State Social Insurance in the Republic of Latvia after Restoring the Independence of the State de facto
Authors: Lazdiņš Jānis 
Published: October 2024

The article is dedicated to an overview of the reforms to the state social insurance law and criticism of some aspects in the reforms carried out in the Republic of Latvia after the restoration of independence de facto in 1990–1991, analysing the rights and obligations of the State, the employer and the employee in the area of social insurance. On the basis of research outcomes, the author concludes that the Soviet understanding of the social insurance law was soon dispensed with. However, it is debatable whether the reforms of social insurance have been successful enough. Although the social insurance contributions are paid in the amount of at least “the minimum amount of the object of mandatory contributions”, it is not clear whether, if an insured case sets in, the disbursed benefit ensures a life that is worthy of human dignity because the subsistence minimum has not been calculated in Latvia. Moreover, not all socially insured persons have all forms of social insurance. Hence, reforms in the area of social insurance cannot be regarded as being completed.
Study of Association Between Glycated Hemoglobin and Lipid Profile in Type 2 Diabetes Mellitus in Tertiary Care Center
Authors: Pandey Tilchan , Khanal Jivan , Godar Krishna Chandra 
Published: October 2024

Introduction: Diabetes is one of the major burdens of non-communicable disease causing morbidity and mortality. Glycated hemoglobin (HbA1c) has been used as a tool to monitor glycemic control in patients with type 2 diabetes mellitus and elevated HbA1c value is considered an independent risk factor for dyslipidemia. Methods: A total of 120 patients with type 2 diabetes mellitus were enrolled in this cross-sectional study. Means with standard deviation were used for age, height, weight and fasting blood sugar and Pearson correlation test was applied to identify correlation between Glycated hemoglobin (HbA1c) and lipid profile. Comparison of means was done by Student 't' test in parametric data within the two groups. P value less than 0.05 was considered significant. Results: The mean HbA1c of male and female patients were 8.35Â±1.77 and 8.65Â±1.95 respectively. Among patients with good glycemic control, mean total cholesterol and mean high density lipoprotein were higher than poor glycemic control patients. Patients with poor glycemic control had higher mean triglyceride and low density lipoprotein than good glycemic control patients. Correlation coefficient for various components of lipid profile and HbA1c were: total cholesterol (r=0.189, p=0.038, n=120), triglyceride (r=0.418, p<0.01, n=120), low density lipoprotein (r=0.673,p<0.01,n=120) and high density lipoprotein ( r=-0.683, p<0.01, n=120). Conclusion: There was a significant moderate correlation between HbA1c and lipid profile. Lipid profile values were significantly higher in poor glycemic control than good glycemic control patients. Hence, HbA1c can be considered as a surrogate marker for dyslipidemia in type 2 DM patients.
Uutismedian tietopyyntöongelmia voisi ratkaista kehittämällä kuntien vuorovaikutusosaamista
Authors: Koski Aleksi , Mykkänen Markus 
Published: October 2024

Katsaus käsittelee julkisuuslain mukaisten tietopyyntöjen ongelmia erityisesti Suomen kuntien viranomaistoiminnassa. Vaikka julkisuuslain uudistustyötä tehdään parhaillaan, tutkimus osoittaa, että pelkästään lainsäädännöllisin keinoin ei voida ratkaista tietopyyntöongelmia. Tulosten perusteella tietopyynnön onnistuminen edellyttää tiedon pyytäjän ja asiankäsittelijän keskinäistä vuorovaikutusta ja toimivaa viestintää organisaation sisällä.
Ehdotuksena on hyödyntää viranomaisten viestinnän ammattilaisia ja kehittää viranomaisten vuorovaikutusosaamista. Avuksi ilmiön hahmottamiseen tarjotaan tietopyyntöjen vuorovaikutusmallia. Mallin avulla voitaisiin parantaa viranomaisorganisaatioiden vuorovaikutusosaamista eri tasoilla ja siten mahdollisesti ratkaista tietopyyntöongelmia.

Englanniksi:
The review examines the challenges related to requests for information under the Finnish Act on the Openness of Government Activities, particularly in the context of municipal authorities. Despite ongoing efforts to reform the legislation, the research indicates that solely relying on legislative measures cannot solve the problems associated with information requests. Based on the findings, the success of an information request requires mutual interaction between the requester and the handler of the matter, as well as effective communication within the organization.
The suggestion is to utilize communication professionals within government agencies and enhance the communication competence of government officials. To aid in understanding this phenomenon, a model for the interaction of information requests is proposed. This model could improve the communication competence of government organizations at various levels and thus potentially address the challenges related to information requests.
Perceived burden in adult and pre-elderly informal caregiver
Authors: Devina Rahmasari  , Nicholas Setiawan Saputra  , Jili Ayutasari  
Published: October 2024

Purpose: Nowadays, caregiver’s role becomes increasingly important in providing care and support for old people who suffered from chronic diseases. Adult and pre-elderly informal caregiver have different growth and development tasks. It is important to identify their perceived burden. The aim of this research was to compare informal caregiver’s perceived burden between adults and pre-elderly.
Method: This research was conducted in Sukoharjo Village between March – December 2023. Research design was cross sectional design and simple random sampling technique was used. Total respondent was 74 persons and categorized into adults and pre-elderly group. The instrument of this research was The Informal Caregiver Burden Assessment Questionnaire (QASCI-The Questionario de Avaliacao de Sobrecarga do Cuidador Informal) which has been tested for validity and reliability.
Result: Significant differences was found between adults and pre-elderly perceived burden (p=0.000). Adults standard deviation was 25,28 higher compared to pre-elderly standard deviation. This was meant that adult perceived burden was greater than pre-elderly.
Conclusion: Adult informal caregiver’s perceived burden was greater than pre-elderly. They have more responsibilities such as taking care of the household, earn living, and educate their children. Good coping mechanisms and family support are needed to overcome the excessive stressors due to caring process.
Conceptualizing social support in families of children with special needs
Authors: Nurul Janah  , Iis Solihah  , Aji Muhammad Iqbal  , Salawat Fatih Ibrahim  
Published: October 2024

Purpose: Families usually try to organize the family environment and reach out to resources that can meet their child's needs. Successful resource utilization is important for families in dealing with the daily challenges and demands of caring for a child with special needs. In particular, social support influences the successful adaptation of these families. The concept of social support is increasingly being used to understand families and their functioning, and this research contributes to the evolving process of adaptation.
Method: This study used systematic literature review design. The article search was carried out from January- March 2022 for the literature on parenting styles for children with special needs.
Result: The results mentioned that one or all of the family members experienced adjustments in their work, i.e. shortened working hours, quit their job, or quit their job. The various adjustments that must be made often lead to various disturbances and stress for parents. The stress experienced by parents is also related to the heavy responsibilities of caring for and raising children. Parents' reactions vary. There are parents who cope realistically, resisting, feeling sorry for themselves. When facing significant stressors, families will go through certain processes that allow them to survive and adapt until they can become a harmonious family.
Conclusion: This social support can be emotional, assistance, or informational because it can have an effect on children with special needs so that they do not have to worry about their own weaknesses. Children with special needs that they do not feel different from normal children. This shows that one of the family functions is working very well.
Antibiotic Susceptibility Profile in Urinary Tract Infection Patients at Tarakan Regional Hospital
Authors: Dharmawan Ade , Wijaya Pande I Gede Indra , Septiana Yorisye , Pasaribu Donna Mesina Rosadini , Tan Henny Tannady , Simanjuntak Lasma Susi F. 
Published: October 2024

Background: Urinary tract infections (UTIs) are common in the community and hospital. In Indonesia, the incidence of UTI reaches 180,000 new cases per year. The most common pathogenic bacteria causing UTIs are dominated by Escherichia coli. Early empirical treatment of UTI cases can reduce morbidity. Knowing the pathogenic bacteria involved in urinary tract infections and their antimicrobial susceptibility patterns is necessary to provide appropriate empirical therapy. Purposes: Describe bacterial patterns and susceptibility profiles in urinary tract infection patients. Methods: A retrospective UTI dataset between 2019-2021whom admitted to Tarakan Regional General Hospital with a diagnosis of UTI. Resistance marker data for ESBL were obtained from the results of identification and resistance using the BD PhoenixTM Automated Microbiology System (Becton Dickinson, USA). The data was analyzed descriptively. Results: As many as 40 isolates were analyzed. Consist of E.coli (37.5%), Enterococcus faecium (20%) and Klebsiella pneumoniae (17.5%). The ESBL-producing E.coli bacteria rate reached 60%, while ESBL-producing K. pneumoniae reached 100%. Conclusion: E. coli was the most common pathogen, with the highest antibiotic sensitivity being imipenem, meropenem, and amikacin.
Techno-Economic Comparison of Total Cost Ownership of Electric and Combustion Light Commercial Vehicles
Authors: Taborda-Ospina Luis , Ortiz-Castrillón Robinson , Jaramillo-Duque Álvaro , López-Lezama Jesús María , Muñoz-Galeano Nicolás 
Published: October 2024

Objective: This study aims to investigate the Total Cost of Ownership (TCO) of an Electric Vehicle (EV) and a Combustion Vehicle (CV) to determine the economic viability of the EV.

Theoretical Framework: Net Present Value (NPV) is used to evaluate costs over a 10-year timeframe, considering purchase prices, insurance, maintenance costs, fixed-term deposit rates, and road taxes.

Method: Two similar commercial light vehicles (Renault Kangoo and Renault Kangoo ZE) are compared using a financial analysis based on NPV.

Results and Discussion: The electric version of the vehicle (Renault Kangoo ZE) proves to be economically attractive, especially with intensive use.

Research Implications: The results suggest that, with intensive use, electric vehicles can be a financially viable option, which could encourage their widespread adoption in the future.

Originality/Value: The value of the study lies in its detailed financial approach to comparing the TCO between an EV and an equivalent combustion vehicle. This analysis allows for the evaluation of the economic viability of electric vehicles, providing a solid basis for decisions on their widespread adoption.
Genomic-Wide Association Studies For Resistance to Anthracnose in a Pseudo-F2 Mango Population
Authors: Santos Carlos Antônio Fernandes , Aquino Deisy Aiane Lima de , Batista Diógenes da Cruz 
Published: October 2024

Goal: This study aimed to apply genome-wide association studies (GWAS) to identify single nucleotide polymorphisms (SNPs) associated with resistance to mango anthracnose.

Theoretical Framework: The statistical methods of GWAS aim to identify associations among genotypes with phenotypes for marker-assisted selection (MAS) or genome dissection of important traits.

Method: Ninety-four plants of a ‘Haden’ × ‘Tommy Atkins’ pseudo-F2 population were genotyped with 705 SNPs and phenotyped for resistance to Colletotrichum siamense, anthracnose causal agent, by spraying young leaves, three times at different periods, with 103 conidia/mL. Qualitative GWAS, with Plink Fisher’s exact test and Cochran-Armitage trend genotypic test, and quantitative GWAS, with Tassel general (GLM) and mixed linear models (MLM) were applied. F2 plants with symptoms mean absence >75% were considered moderately resistant to the fungus.

Results and discussion: Qualitative and quantitative GWAS methods combined enable the identification of two consensus SNP loci controlling 24.76% of total variance to mango anthracnose resistance. Other four SNPs, identified, exclusively in quantitative or qualitative analysis, explained 28.55% of total variance to mango anthracnose. These SNPs loci are promising candidate for further PCR primers design in order to apply MAS in mango.

Research implications: This study facilitates the identification of consensus chromosomal regions associated with mango anthracnose resistance. The application of MAS in mango breeding will accelerate the development of new cultivars.

Originality/Value: To our knowledge, this a pioneering GWAS study applied to anthracnose, which is the most significant and widespread fungal disease affecting mango fruit globally.