bluuebunny/crossref_metadata_2025_split huggingface dataset:
Metodología para la mejora arquitectónica de repositorios universitarios
Authors: Fernández-Luna Adrià , Pérez-Montoro Mario , Guallar Javier 
Published: October 2019

Se propone la utilización de metodologías propias de la disciplina de la Arquitectura de la información para mejorar el acceso a los contenidos de los repositorios universitarios o institucionales. Se ha observado que en la mayoría (80%) de los repositorios universitarios se utiliza una implementación por defecto del software DSpace. El hecho de no adecuar la arquitectura del repositorio a las necesidades de la universidad y sus usuarios puede generar una mala experiencia de usuario llegando a generar búsquedas insatisfactorias en una de cada tres interacciones. Este obstáculo en la recuperación de documentos puede evolucionar en una falta de visibilidad de la producción científica de la institución. Por ello se hace una propuesta metodológica para mejorar la arquitectura de los repositorios basada en las técnicas de User Persona y de Card Sorting empleando herramientas gratuitas como Google Forms, y se aplica la metodología a un estudio de caso: el Dipòsit Digital de la UB.
The article proposes the use of methodologies of the discipline of Information Architecture to improve access to the contents of institutional repositories. It has been observed that in the majority (80%) of the university repositories a default implementation of the DSpace software is used. The fact of not adapting the architecture of the repository to the needs of the university and its users can generate a bad user experience, generating unsatisfactory searches in one of every three interactions. This obstacle in the recovery of documents can evolve in a lack of visibility of the scientific production of the institution. Therefore, a methodological proposal is made to improve the architecture of the repositories based on the techniques of User Persona and Card Sorting using free tools such as Google Forms, and this methodology is applied to a case study: Dipòsit Digital of the UB.
Opiniões, necessidades e preferências dos utilizadores das bibliotecas hospitalares
Authors: Saraiva Rosa , Frías José Antonio , Lopes Carlos 
Published: October 2019

Se presentan los resultados de un estudio sobre las opiniones, necesidades e intereses de los usuarios de las bibliotecas hospitalarias de la zona centro de Portugal. Esta investigación se llevó a cabo con la finalidad de conocer si los recursos y servicios de las bibliotecas de los hospitales contribuyen a la calidad de los cuidados prestados a los pacientes, a la práctica de la investigación y a la formación continua de los profesionales. Para ello se llevó a cabo una encuesta a 121 usuarios de las bibliotecas de siete hospitales de la zona centro de Portugal. Los resultados ponen de manifiesto las fortalezas y debilidades de los servicios bibliotecarios, a menudo poco conocidos, y cuya valoración varía dependiendo del tipo de usuario y de las iniciativas desarrolladas por las propias bibliotecas.
The results of a study about the opinions, needs and interests of the users of the hospital libraries of the central area of Portugal are presented. This research was carried out with the purpose of knowing if the resources and services of the libraries of the hospitals contribute to the quality of the care provided to the patients, to the practice of the research and to the continuous training of the professionals. For this purpose, a survey was carried out to 121 users of the libraries of seven hospitals in the central area of Portugal. The results highlight the strengths and weaknesses of library services, often little known, and whose assessment varies depending on the type of user and the initiatives developed by the libraries themselves.
The Satisfaction of Patients Assisted by a Health Education Ambulatory / Satisfação dos Pacientes Atendidos no Ambulatório de Educação em Saúde
Authors: Coutinho Ana Flávia Pereira , Lopes Juliana de Lima , Carneiro Camila de Souza , Santos Vinícius Batista , Barros Alba Lucia Bottura Leite de 
Published: October 2019

Objetivo: Identificar a satisfação dos pacientes acompanhados em um Ambulatório de Educação em Saúde e avaliar o efeito das variáveis antecedentes com o grau de satisfação dos pacientes. Métodos: Trata-se de um estudo de corte transversal, realizado em um Ambulatório de Educação em Saúde. A amostra foi composta por todos os pacientes cardiopatas atendidos neste ambulatório (17 pacientes). A satisfação dos pacientes foi avaliada por meio do instrumento Satisfação do Paciente (ISP). Resultados: Observou-se que todos os pacientes relataram um alto nível de satisfação e os domínios que obtiveram maiores e menores pontuações foram o profissional e o educacional, respectivamente. Não houve correlação significativa do nível de satisfação com nenhuma das variáveis antecedentes. Conclusão: Os pacientes apresentaram alto nível de satisfação e nenhuma variável se relacionou com a satisfação.
The application of omics-based human liver platforms for investigating the mechanism of drug-induced hepatotoxicity in vitro
Authors: Jiang Jian , Pieterman Charlie D. , Ertaylan Gökhan , Peeters Ralf L. M. , de Kok Theo M. C. M. 
Published: October 2019

Abstract
Drug-induced liver injury (DILI) complicates safety assessment for new drugs and poses major threats to both patient health and drug development in the pharmaceutical industry. A number of human liver cell-based in vitro models combined with toxicogenomics methods have been developed as an alternative to animal testing for studying human DILI mechanisms. In this review, we discuss the in vitro human liver systems and their applications in omics-based drug-induced hepatotoxicity studies. We furthermore present bioinformatic approaches that are useful for analyzing toxicogenomic data generated from these models and discuss their current and potential contributions to the understanding of mechanisms of DILI. Human pluripotent stem cells, carrying donor-specific genetic information, hold great potential for advancing the study of individual-specific toxicological responses. When co-cultured with other liver-derived non-parenchymal cells in a microfluidic device, the resulting dynamic platform enables us to study immune-mediated drug hypersensitivity and accelerates personalized drug toxicology studies. A flexible microfluidic platform would also support the assembly of a more advanced organs-on-a-chip device, further bridging gap between in vitro and in vivo conditions. The standard transcriptomic analysis of these cell systems can be complemented with causality-inferring approaches to improve the understanding of DILI mechanisms. These approaches involve statistical techniques capable of elucidating regulatory interactions in parts of these mechanisms. The use of more elaborated human liver models, in harmony with causality-inferring bioinformatic approaches will pave the way for establishing a powerful methodology to systematically assess DILI mechanisms across a wide range of conditions.
Personalised Warfarin Dosing in Children Post-cardiac Surgery
Authors: Al-Metwali Basma Zuheir , Rivers Peter , Goodyer Larry , O’Hare Linda , Young Sanfui , Mulla Hussain 
Published: October 2019

Abstract
Warfarin dosing is challenging due to a multitude of factors affecting its pharmacokinetics (PK) and pharmacodynamics (PD). A novel personalised dosing algorithm predicated on a warfarin PK/PD model and incorporating CYP2C9 and VKORC1 genotype information has been developed for children. The present prospective, observational study aimed to compare the model with conventional weight-based dosing. The study involved two groups of children post-cardiac surgery: Group 1 were warfarin naïve, in whom loading and maintenance doses were estimated using the model over a 6-month duration and compared to historical case-matched controls. Group 2 were already established on maintenance therapy and randomised into a crossover study comparing the model with conventional maintenance dosing, over a 12-month period. Five patients enrolled in Group 1. Compared to the control group, the median time to achieve the first therapeutic INR was longer (5 vs. 2 days), to stable anticoagulation was shorter (29.0 vs. 96.5 days), to over-anticoagulation was longer (15.0 vs. 4.0 days). In addition, median percentage of INRs within the target range (%ITR) and percentage of time in therapeutic range (%TTR) was higher; 70% versus 47.4% and 83.4% versus 62.3%, respectively. Group 2 included 26 patients. No significant differences in INR control were found between model and conventional dosing phases; mean %ITR was 68.82% versus 67.9% (p = 0.84) and mean %TTR was 85.47% versus 80.2% (p = 0.09), respectively. The results suggest model-based dosing can improve anticoagulation control, particularly when initiating and stabilising warfarin dosing. Larger studies are needed to confirm these findings.
Modelling collective cell migration: neural crest as a model paradigm
Authors: Giniūnaitė Rasa , Baker Ruth E. , Kulesa Paul M. , Maini Philip K. 
Published: October 2019

AbstractA huge variety of mathematical models have been used to investigate collective cell migration. The aim of this brief review is twofold: to present a number of modelling approaches that incorporate the key factors affecting cell migration, including cell–cell and cell–tissue interactions, as well as domain growth, and to showcase their application to model the migration of neural crest cells. We discuss the complementary strengths of microscale and macroscale models, and identify why it can be important to understand how these modelling approaches are related. We consider neural crest cell migration as a model paradigm to illustrate how the application of different mathematical modelling techniques, combined with experimental results, can provide new biological insights. We conclude by highlighting a number of future challenges for the mathematical modelling of neural crest cell migration.
Different vascular healing process between bioabsorbable polymer-coated everolimus-eluting stents versus bioresorbable vascular scaffolds via optical coherence tomography and coronary angioscopy (the ENHANCE study: ENdothelial Healing Assessment with Novel Coronary tEchnology)
Authors: Wan Ahmad Wan Azman , Nakayoshi Takaharu , Mahmood Zuhdi Ahmad Syadi , Ismail Muhammad Dzafir , Zainal Abidin Imran , Ino Yasushi , Kubo Takashi , Akasaka Takashi , Fukumoto Yoshihiro , Ueno Takafumi 
Published: October 2019

Abstract
Recent clinical trials have raised concerns about the safety and efficacy of ABSORB™ bioresorbable vascular scaffolds (BVS). The difference in the vascular healing process between SYNERGY™ bioabsorbable polymer-coated everolimus-eluting stents (BP-EES) and BVS remains unclear. The aim of the ENHANCE study was to compare vascular healing on BP-EES versus BVS by optical coherence tomography (OCT) and coronary angioscopy (CAS) at 4- and 12-month follow-ups. This is a prospective, non-randomized, single center clinical trial. Thirteen eligible patients with multivessel disease were enrolled. BP-EES and BVS were simultaneously implanted in the same patients, but in different coronary vessels. Imaging follow-up with both OCT and CAS was completed in 11 patients at 12 months. Neointimal coverage rates were similar between the two groups based on OCT measurements. The neointimal thickness of BP-EES was significantly thicker at the 12th month than at the 4th month, whereas the neointimal thickness of BVS did not change between the measurements taken at the 4th and 12th month. Existence of intra-stent thrombus was significantly higher in the BVS group, compared to the BP-EES group. On the other hand, CAS revealed that red-thrombi and yellow-plaque were more frequently observed in BVS at 4 months and up to 12-month follow-ups than in BP-EES. These findings suggested that the evidence of instability remained up to 12 months in the vascular healing with BVS, compared to that with BP-EES. Vascular healing of the stented wall was recognized at the very early phase after BP-EES implantation. However, vascular healing with BVS was still incomplete after 12 months.
Negative allometric growth during ontogeny in the large pelagic filter-feeding basking shark
Authors: Ahnelt Harald , Sauberer Michael , Ramler David , Koch Laura , Pogoreutz Claudia 
Published: October 2019

AbstractMany pelagic shark species change body and fin shape isometrically or by positive allometry during ontogeny. But some large apex predators such as the white shark Carcharodon carcharias or the tiger shark Galeocerdo cuvier show distinct negative allometry, especially in traits related to feeding (head) or propulsion (caudal fin). In particular, changes in propulsion are attributed to a shift in swimming mode. The more heterocercal caudal fin of younger individuals with its large caudal fin span seemingly aids in hunting small, agile prey. In contrast, the less heterocercal caudal fin with a larger fin area in larger individuals aids a long-distance slow swimming mode. We were interested if negative allometric effects can be observed in a planktivorous shark, the basking shark Cetorhinus maximus, a large species adapted to long-distance slow swimming. To address this question, we compared three size classes, specifically < 260 cm (juveniles), 299–490 cm (subadults), and from adults > 541 cm total length. Comparing literature data, we found negative allometric growth of the head and of the caudal fin, but a more rapid decrease of relative caudal fin size than of relative head length. Hereby, we provide the first evidence for early negative allometric growth of the caudal fin in a large pelagic filter-feeding shark. Our study further demonstrates that ecomorphological approaches may add valuable insight into the life history of animals that are challenging to study in their natural habitat, including large roving sharks such as the basking shark.
Environmental-friendly one-pot cascade synthesis of 3-cyanopiperidin-2,6-diones
Authors: Paprocki Daniel , Berłożecki Stanisław , Ostaszewski Ryszard 
Published: October 2019

Abstract
3-Cyanopiperidin-2,6-diones are key intermediates in the synthesis of several drugs and natural products. We developed one-pot synthesis of 3-cyanopiperidin-2,6-diones by Knoevenagel condensation of cyanoacetic acid and aldehydes, followed by addition of cyanoacetic acid, Achmatowicz reaction and decarboxylation. We tested a wide range of aliphatic and aromatic aldehydes. Products were obtained under simple, environmentally friendly conditions and in yields up to 99%. Substrates were stirred in toluene at reflux, and filtered through short pad of silica gel, and the product was purified by recrystallization.
Maternal cannibalism in two populations of wild chimpanzees
Authors: Fedurek Pawel , Tkaczynski Patrick , Asiimwe Caroline , Hobaiter Catherine , Samuni Liran , Lowe Adriana E. , Dijrian Appolinaire Gnahe , Zuberbühler Klaus , Wittig Roman M. , Crockford Catherine 
Published: October 2019

AbstractMaternal cannibalism has been reported in several animal taxa, prompting speculations that the behavior may be part of an evolved strategy. In chimpanzees, however, maternal cannibalism has been conspicuously absent, despite high levels of infant mortality and reports of non-maternal cannibalism. The typical response of chimpanzee mothers is to abandon their deceased infant, sometimes after prolonged periods of carrying and grooming the corpse. Here, we report two anomalous observations of maternal cannibalism in communities of wild chimpanzees in Uganda and Ivory Coast and discuss the evolutionary implications. Both infants likely died under different circumstances; one apparently as a result of premature birth, the other possibly as a result of infanticide. In both cases, the mothers consumed parts of the corpse and participated in meat sharing with other group members. Neither female presented any apparent signs of ill health before or after the events. We concluded that, in both cases, cannibalizing the infant was unlikely due to health-related issues by the mothers. We discuss these observations against a background of chimpanzee mothers consistently refraining from maternal cannibalism, despite ample opportunities and nutritional advantages. We conclude that maternal cannibalism is extremely rare in this primate, likely due to early and strong mother–offspring bond formation, which may have been profoundly disrupted in the current cases.
Determination of optimal build orientation for additive manufacturing using Muirhead mean and prioritised average operators
Authors: Qin Yuchu , Qi Qunfen , Scott Paul J. , Jiang Xiangqian 
Published: October 2019

AbstractBuild orientation determination is one of the essential process planning tasks in additive manufacturing since it has crucial effects on the part quality, post-processing, build time and cost, etc. This paper introduces a method based on fuzzy multi-attribute decision making to determine the optimal build orientation from a finite set of alternatives. The determination process includes two major steps. In the first step, attributes that are considered in the determination and heterogeneous relationships of which are firstly identified. A fuzzy decision matrix is then constructed and normalised based on the values of the identified attributes, which are quantified by a set of fuzzy numbers. In the second step, two fuzzy number aggregation operators are developed to aggregate the fuzzy information in the normalised matrix. By comparing the aggregation results, a ranking of all alternative build orientations can then be generated. Two determination examples are used to demonstrate the working process of the proposed method. Qualitative and quantitative comparisons between the proposed method and other methods are carried out to demonstrate its feasibility, effectiveness, and advantages.
The Myth of the Stupid Believer: The Negative Religiousness–IQ Nexus is Not on General Intelligence (g) and is Likely a Product of the Relations Between IQ and Autism Spectrum Traits
Authors: Dutton Edward , te Nijenhuis Jan , Metzen Daniel , van der Linden Dimitri , Madison Guy 
Published: October 2019

Abstract
Numerous studies have found a negative relationship between religiousness and IQ. It is in the region of − 0.2, according to meta-analyses. The reasons for this relationship are, however, unknown. It has been suggested that higher intelligence leads to greater attraction to science, or that it helps to override evolved cognitive dispositions such as for religiousness. Either way, such explanations assume that the religion–IQ nexus is on general intelligence (g), rather than some subset of specialized cognitive abilities. In other words, they assume it is a Jensen effect. Two large datasets comparing groups with different levels of religiousness show that their IQ differences are not on g and must, therefore, be attributed to specialized abilities. An analysis of the specialized abilities on which the religious and non-religious groups differ reveals no clear pattern. We cautiously suggest that this may be explicable in terms of autism spectrum disorder traits among people with high IQ scores, because such traits are negatively associated with religiousness.
Video Advance Directives: A Turning Point for Advance Decision-Making? A Consideration of Their Roles and Implications for Law and Practice
Authors: Chan Hui Yun 
Published: October 2019

Abstract
Questions regarding making and implementing care preferences through advance directives have become increasingly significant as the greying population grows with rising numbers of people experiencing incapacity. Currently, there is no consensus in the format for making advance directives. Recent developments highlighted the use of recording technology as an option to counter the challenges of written forms. Services offering video and audio recording available for online and offline storage are emerging in the United States. These services presumably strengthen a person’s expression of care preferences for healthcare providers in making treatment decisions compared to written advance directives. This article examines the role video advance directives play in advance decision-making and their legal and practical implications to the existing framework. An appreciation of the legal challenges presented by this development facilitates an understanding of their use in contemporary advance directives and enables appropriate recommendations for implementing safeguards in their use.
Propidium monoazide–polymerase chain reaction for detection of residual periprosthetic joint infection in two-stage revision
Authors: Askar Mohamed , Sajid Mariam , Nassif Yassar , Ashraf Waheed , Scammell Brigitte , Bayston Roger 
Published: October 2019

AbstractFalse negative culture results in periprosthetic joint infection (PJI) are not uncommon particularly when patients have received long term antibiotics. Polymerase chain reaction (PCR) has a lower specificity partly due to detection of residual DNA from dead bacteria. Propidium monoazide (PMA) prevents DNA from dead bacteria from being amplified during the PCR. This study aimed to determine the role of PMA in PCR for diagnosis of PJI. Clinical samples were tested by PCR with and without prior treatment with PMA and compared to conventional microbiological culture. The PCR assay included genus-specific primers for staphylococci and enterococci and species-specific primers for Cutibacterium acnes. The validated conditions of PMA treatment used in this study were 20 μM concentration and 5 and 10 min of dark incubation and photo-activation respectively. 202 periprosthetic tissues and explanted prostheses from 60 episodes in 58 patients undergoing revision arthroplasties for either PJI or non-infective causes were tested, by culture, PCR, and PMA-PCR. 14 of the 60 episodes satisfied the Musculoskeletal Infection Society (MSIS) criteria for PJI and 46 did not. Sensitivity of culture, PCR, and PMA-PCR were 50%, 71%, and 79% respectively. Specificities were 98%, 72%, and 89% respectively. All figures were calculated for episodes rather than samples. PMA-PCR enhanced both the specificity and the sensitivity of PCR. It has the potential to detect residual bacterial viability prior to reimplantation in the two-stage revision for PJI.