bluuebunny/crossref_metadata_2025_split huggingface dataset:
THE OPPORTUNITY OF MONITORING AND OPTIMIZATION OF THE VOLEMIC STATUS IN PATIENTS WITH SEPSIS
Authors: Yamshchikov O. N. , Zakurnaeva E. I. , Marchenko A. P. , Emelyanov S. A. , Arhipov K. P. , Marchenko N. A. 
Published: December 2024

Relevance. The relevance of the problem of the volemic status (VS) correction in patients with sepsis, especially with septic shock and multiple organ failure is beyond doubt, because in this condition there are always significant and life-threatening changes in homeostasis, especially in the circulatory system. At the same time, the percent of deaths remains high, and uncertainty in the pathophysiological mechanisms and an erased clinical picture can lead to untimely diagnosis and delayed correction of circulating blood volume (CBV).Aim of research. To analyze and summarize current concepts about the assessment of CBV in sepsis and septic shock. To identify current approaches to infusion therapy in this pathology in order to increase the efficiency of treatment and knowledge of specialists.Materials and methods. During writing the article, the search for literary sources was carried out in the databases: PubMed, eLibrary, CyberLeninka over the past 5 years, as well as from earlier sources that have not lost their relevance. At the same time, free access to the full content of publications was used in accordance with the subject of the review.Conclusion. The choice of infusion therapy tactics for patients with sepsis and polymorbidity may present significant difficulties due to the limited number of methods for monitoring and correcting volemic status. At the same time, the difficulty of making a decision is due to the multifactorial nature of the parameters and the inconsistency of the results obtained. In this situation, the result of treatment can be improved by using a combined analysis of parameters, prioritizing dynamic rather than static indicators. Methods of research and control of VS based on ultrasound technologies are more accessible and preferable in use for most medical preventive institutions (MPI) to determine the strategy of infusion therapy in the treatment of sepsis. The topic of control and correction of volemic status needs further research.
BIOMARKERS OF ACUTE KIDNEY INJURY OF BLOOD SERUM IN PATIENTS WITH THERMAL SKIN BURNS
Authors: Konovalova A. A. , Tsepelev V. L. 
Published: December 2024

The aim: to evaluate the dynamics of changes in the level of biomarkers of acute kidney injury – lipocalin and cystatin C in blood serum in patients with thermal skin burns.Materials and methods. The study included 74 patients with thermal skin burns of I-III degree with a skin lesion area of more than 25%, of which at least 15% are deep burns. Serum creatinine levels were determined using the kinetic Jaffe method. Lidocaine and cystatin C concentrations were studied by multiplex analysis on a flow cytofluorimeter.Results. It was found that the concentration of cystatin C in the blood serum during burn shock increases by 1,9 times, with burn toxemia and septicotoxemia - by 1,5 times in relation to the control group. The level of lipocalin in the blood serum of patients with thermal skin burns during the shock period increases by 5,5 times compared to the control group. During the period of burn toxemia and septicotoxemia, lidocaine concentration remained at a high level and exceeded the control values by 4,4 and 3,6 times, respectively.Conclusion. Lipocaine and cystatin C can be considered as early biomarkers of acute kidney injury in patients with thermal skin burns.
Delayed breast reconstruction with the thoracodorsal flap and endoprosthesis after complex treatment of breast cancer
Authors: Bosieva A. R. , Zikiryakhodzhaev A. D. , Usov F. N. , Khakimova Sh. G. , Efanov V. V. 
Published: December 2024

Breast reconstruction with a thoracodorsal flap (TDF) in combination with a tissue expander/implant is a wellestablished technique.The purpose of the study was to present current data on the results of delayed breast reconstruction with thoracodorsal flap and tissue expander after combined/complex treatment in patients with breast cancer.Material and methods. The search for relevant sources was carried out in the PubMed, Cochrane Library, E-library systems, publications from 2014 to 2022 were studied. Delayed breast reconstruction using TDF in combination with a tissue expander/implant is a reliable method of reconstruction for the group of patients who have previously undergone radical mastectomy or adjuvant external beam radiation therapy in terms of combined/complex treatment of breast cancer, allowing to achieve good and excellent aesthetic results with a low incidence of surgical complications.Results and discussion. The use of the latissimus dorsi flap is a reliable and universal method of breast reconstruction, it allows achieving good and excellent aesthetic results, high patient satisfaction. Patients with a low body mass index or obesity, a history of abdominal surgery, including abdominoplasty, are not candidates for reconstruction using anterior abdominal wall flaps, and therefore the only possible method of breast reconstruction for them is the method using the TDF. In addition, the use of the TDF may be most appropriate for women who are planning a pregnancy in the future and for whom the use of anterior abdominal wall flaps will not be an optimal method of reconstruction due to reduced abdominal wall compliance. Other reasons why the use of TDF is the method of choice for many surgeons are the possibility of closing the donor site regardless of the size of the skin flap taken, the possibility of closing such defects of the mammary gland as extrusions, protrusions, in case of insufficiency of the skin cover after skin-preserving mastectomies.Conclusion. The use of the latissimus dorsi flap is a reliable and universal method of breast reconstruction, it allows achieving good and excellent aesthetic results, a high degree of patient satisfaction.
Pathomorphologic features of the structure of hyperextensible eyelid tissues
Authors: Grishchenko S. V. , Borhunova E. N. , Filatova I. A. , Kartasheva A. F. , Ushano G. T. 
Published: December 2024

Purpose of a study: to identify pathomorphological features of hyperextensible eyelids for planning and predicting the outcome of blepharoplasty.Material and methods. 352 patients (100%) with involutional eyelid changes, indications for aesthetic blepharoplasty were examined. Out of the total number of the study participants 87 patients (24.7%) had clinical signs of hyperextensible eyelids (HES): ‘festoons’, hypotonia of the lower eyelids with positive ‘pinch test’, pronounced skin folds and free easy displacement of lax tissues of eyelids, face and neck, pseudoblepharochalasis, ptosis of eyebrows, dystopia of the external corners of the eyes and risk factors of postoperative eyelid retraction. We analysed surgical biopsies of the skin, circular muscle of the eye, and tarsal plate after blepharoplasty operations from 28 patients aged from 41 to 60 years with clinical manifestations of HES combined with hyperelastosis (17 patients) and blepharochalasis (11 patients).Results. Typical morphological signs of hyperextensibility of the eyelid skin, circular muscle of the eye, and tarsal plate have been established: sclerosis, focal dystrophy of the intercellular substance, moderate macrophagelymphocytic infiltration with eosinophils markers of chronic inflammation, and necrosis of adipocytes and meibomian glands. In HES in eyelid skin elastic fibres are registered in small quantity, fragmented, single with signs of destruction; in blepharochalasis they are absent; collagen fibres are significantly thinned, which leads to a decrease in elasticity, tone and turgor of the skin.Conclusion. Morphological changes in tissue structure in HES combined with blepharochalasis and hyperelasticity directly correlate with clinical manifestations of HES. It is advisable to identify such patients at the stage of blepharoplasty planning, classify them as a risk group for secondary postoperative deformities and apply to them gentle blepharoplasty techniques with elements of eyelid strengthening.
Comparative evaluation of the quality of life of patients after mastectomy and non-flapped breast reconstructions for cancer
Authors: Petrosyants S. V. , Aydemirov A. N. , Ivanov D. V. , Sergeev D. I. , Rovenskikh D. N. 
Published: December 2024

Purpose of the study: to compare the quality of life of patients who underwent mastectomy and non-flapped breast reconstructions for cancer.The study included 90 patients, diagnosed with breast cancer 0–IIA st. T1–2N0M0. The minimum age of the patients was 30 years old, the maximum was 65 years, the average age was (49.76 ± 8.54) years old. Patients were divided into three groups of 30 women depending on the type of surgical treatment of the tumor and breast reconstruction: 1st group – Madden surgery with a subsectoral expander installation and replacement with a silicone endoprosthesis, 2nd group – Madden surgery with prepectoral expander installation, staged lipofilling and replacement with silicone endoprosthesis, 3rd group – radical subcutaneous mastectomy with one-stage prepectoral breast reconstruction. The quality of life was assessed using a set of Breast-Q scales.The data obtained make it possible to draw conclusions about the effectiveness of subcutaneous mastectomy with one-stage prepectoral breast reconstruction according to the method proposed by the authors due to the tendency to a more intensive increase of the quality of life of patients at the stages of rehabilitation in such aspects as psychosocial, physical and sexual well-being.
“PREVALENCIA DE MICROFILAREMIA DE Dirofilaria immitis EN PERROS DOMÉSTICOS DE LA COMUNA OLÓN DE LA PROVINCIA DE SANTA ELENA”
Authors: Parra-Guayasamín Sandra Gabriela , Tuarez Villón Kleiner Agustín , Orrala Mendoza Angela Estefanía 
Published: December 2024

La Dirofilariasis es una patología transmitida por el nemátodo Dirofilaria immitis, los vectores que ayudan a su transmisión son los mosquitos Culex, Aedes, Anopheles o Mansonia. Se encontró con este estudio la prevalencia de microfilarias en perros domésticos, por medio de un muestreo dirigido, se recogieron muestras de sangre de 30 perros, estas fueron procesadas mediante la técnica de identificación microscópica de microfilarias denominada “técnica de Knott”, se obtuvo 10 casos positivos, estableciendo una prevalencia del 33.3%. Los datos obtenidos se procesaron por la prueba paramétrica de Chi Cuadrado, mediante el software SPSS, dando como resultado que la variable desparasitación (interna) presentó datos estadísticamente significativos, demostrando que existe relación entre la variable y la presencia de microfilarias en circulación sanguínea de perros domésticos, sino más bien de la periodicidad de desparasitación que se le brinde a la mascota.
Pengaruh Pengasuhan Permisif dan Otoriter terhadap Siswa Pelaku Bullying di Sekolah X Kota Sorong
Authors: Ariska Fika Suci , Shofia Adinda , Wahyuni Nengsih Sri 
Published: December 2024

Tujuan dari penelitian ini adalah untuk mengetahui pengaruh pengasuhan otoriter terhadap pelaku bullying di sekolah X kota Sorong, pengaruh pengasuhan permisif terhadap pelaku bullying di sekolah X kota Sorong, pengaruh pengasuhan otoriter dan permisif terhadap siswa perilaku bullying di sekolah X kota Sorong. Penelitian ini menggunakan pendekatan kuantitatif dengan jumlah 100 responden di sekolah X kota Sorong. Teknik pengambilan sampel pada penelitian ini menggunakan teknik random sampling dengan teknik analisis 2 prediktor yaitu analisis regresi linear berganda. Hasil penelitian ini yaitu uji t yaitu nilai sig Otoriter berjumlah 0,001 yang artinya berpengaruh terhadap variabel Y dependen yaitu Bullying, sedangkan nilai sig Permisif berjumlah 0,822 yang artinya tidak berpengaruh terhadap variabel Y dependen yaitu Bullying dan hasil uji F diperoleh nilai sebesar 8,56 dan nilai signifikan sebesar 0,00 yang dimana lebih kecil dari 0,05, maka variabel independen yang meliputi pengasuhan Otoriter dan Permisif berpengaruh secara simultan terhadap variabel dependen Bullying.
ПОТЕНЦИАЛ ЮАНЕВЫХ КОРПОРАТИВНЫХ ОБЛИГАЦИЙ НА РОССИЙСКОМ ФОНДОВОМ РЫНКЕ
Authors: В.В. Таквель 
Published: December 2024

Целью статьи является оценка потенциала номинированных в юанях корпоративных облигаций на российском фондовом рынке. Актуальность поставленной цели обусловлена тем, что с введением санкций и ограничением доступа к западным рынкам капитала именно юань становится перспективной альтернативой доллару и евро. В процессе исследования автором были систематизированы риски юаневых облигаций, также автором получен вывод, что юаневые облигации представляют собой устойчивый инструмент для инвесторов, заинтересованных в диверсификации и снижении санкционных и валютных рисков. Описаны спекулятивная и консервативная стратегии управления портфелем юаневых облигаций. Сделано предположение, что в долгосрочной перспективе облигации, номинированные в юанях, могут занять устойчивую позицию в портфелях как российских, так и иностранных инвесторов, особенно если будут обеспечены дальнейшие меры по поддержанию их ликвидности и доступности. Получен вывод, что в условиях санкций, ограничивающих доступ к западным капиталовложениям и валютам, юань рассматривается как перспектива для диверсификации валютных рисков и снижения зависимости от традиционных валют, таких как доллар и евро. Для эмитентов юаневые облигации позволяют преодолеть ограничения доступа к рынкам капитала, а для инвесторов юаневые облигации представляют собой инструменты сокращения валютных рисков, особенно в условиях волатильности рубля. Таким образом, несмотря на присутствие валютных и политических рисков, потенциал юаневых облигаций на российском рынке можно считать высоким.
The purpose of the article is to assess the potential of yuan-denominated corporate bonds on the Russian stock market. The relevance of the objective is due to the fact that with the introduction of sanctions and restricted access to Western capital markets, the yuan becomes a promising alternative to the dollar and euro. In the process of research the author systematized the risks of yuan bonds, also the author obtained the conclusion that yuan bonds are a stable instrument for investors interested in diversification and reduction of sanctions and currency risks. Speculative and conservative strategies of yuan bonds portfolio management are described. An assumption is made that in the long term yuan-denominated bonds can occupy a stable position in the portfolios of both Russian and foreign investors, especially if further measures are taken to maintain their liquidity and availability. It is concluded that in the face of sanctions restricting access to Western investments and currencies, the RMB is seen as a prospect for diversifying currency risks and reducing dependence on traditional currencies such as the dollar and the euro. For issuers, RMB bonds overcome restrictions on access to capital markets, and for investors, RMB bonds represent tools to reduce currency risks, especially in the face of ruble volatility. Thus, despite the presence of currency and political risks, the potential of RMB bonds in the Russian market can be considered high.
Development of Teaching Materials to Support Merdeka Curriculum Learning on Salt Hydrolysis for Phase F Senior High School
Authors: Mardhiyatul Khairat  , Mawardi  , Okta Suryani  , Reza Akmar  
Published: December 2024

This aims of this research is to develop teaching materials that incorporate multiple representations of chemistry concepts, especially on the salt hydrolysis topic, to support the Merdeka Curriculum and improve students' mental models in the F phase of high school. Educational Research Development (EDR) is the method chosen, using Plomp’s development model. The subject are three UNP chemistry lecturers, two chemistry teachers and nine SMAN 8 Padang students. The developed teaching material have been validated with a construct validity value of 0.89 which is classified as valid and. Then it has also been tested for practicality with a score of 96% from teachers and 94% from students, this shows that the development teaching materials are very practical, which indicates their ease of use and application in an educational environment. It concludes, that the developed teaching materials are for the topic of salt hydrolysis, which incorporate a comprehensive range of chemical representations proven to be valid and highly practical can effectively assist students in building mental models and improving their understanding of chemical concepts and support the goals of the Merdeka Curriculum in fostering deeper student understanding.
De financiering van een noodzakelijke verhuizing: schade of faciliteringsplicht?
Authors: Van A.J. , Salhi D. 
Published: December 2024

De financiering van een noodzakelijke verhuizing: schade of faciliteringsplicht?
Het komt regelmatig voor dat een benadeelde die ernstig letsel heeft opgelopen daardoor wordt genoodzaakt te verhuizen naar een andere woning. Die zal vaak ruimer moeten zijn, waardoor de aanschafprijs hoger ligt. Die hogere aanschafprijs vormt juridisch gezien geen verhaalbare schade. Wel rust op de aansprakelijke partij de verplichting ervoor te zorgen dat de benadeelde naar een geschikte woning kan verhuizen. Het niet naleven van deze faciliteringsplicht kan ertoe leiden dat de aansprakelijke partij, boven op de reguliere schadevergoeding, aan de benadeelde een vervangende schadevergoeding dient te betalen. Die kan aanzienlijk oplopen. De aansprakelijke partij doet er derhalve verstandig aan tijdig met de benadeelde in overleg te treden en te bezien of, en zo ja, onder welke voorwaarden de meerprijs kan worden verrekend met de toekomstige schade van de benadeelde.
ASSISTÊNCIA DE ENFERMAGEM NO ATENDIMENTO AO PACIENTE DIAGNOSTICADO COM TRANSTORNO DO ESPECTRO AUTISTA INFANTIL (TEA)
Authors: Lemos Larissa Laura , Lopes Victor Eduardo Benevides , Carneiro Patricia Alves Pereira , Borges Milleny Vitória Andrade , Pinheiro Bruno Bernardes Fárão Marques , Brito Tainara Costa de , Lima Cristiane Pereira de , Oliveira Layane de Fátima da Silva Pereira 
Published: December 2024

O presente artigo busca ressaltar a importância do conhecimento de um profissional de enfermagem nas ações adequadas ao prestar assistência de enfermagem ao paciente diagnosticado com Transtorno do Espectro Autista Infantil. Além disso, destaca-se a importância na atenção aos sinais de suspeita inicial, o auxílio e acompanhamento do paciente, a orientação e informação aos familiares e as melhores condutas terapêuticas a serem abordadas em caso de confirmação do diagnóstico de TEA infantil. O trabalho busca conjuntamente avaliar o planejamento do enfermeiro frente a assistência ao paciente diagnosticado com TEA infantil e propor uma sistematização de assistência de enfermagem direcionada a esses pacientes. Neste intuito foram coletados alguns dados de pessoas que convivem com uma criança diagnosticada com o transtorno do espectro autista e informações de como foram suas experiências com o processo até o diagnóstico e simultâneo a suas vivências com os atendimentos da criança em unidades de saúde. Adiantando alguns resultados é possível ressaltar que o Transtorno do Espectro autista é um distúrbio de neurodesenvolvimento que afeta áreas responsável pela fala, comportamento, agressividade, agitação e até o desenvolvimento motor do indivíduo; e os sintomas podem ser reconhecidos nos primeiros 12 até 36 meses de idade podendo chegar ao diagnóstico final precocemente. Por fim pode-se constatar que existem diferentes graus de seriedade do autismo e cada grau necessita de um tratamento específico dependendo de sua complexidade, por isso, é necessário um amplo conhecimento na área para melhor prestação de serviços de saúde.
ELABORAÇÃO DE INFOGRÁFICOS PARA CAPACITAÇÃO DE ENFERMEIROS EM CATETERISMO EPICUTÂNEO AUXILIADO POR ULTRASSOM EM RECÉM-NASCIDOS
Authors: De Oliveira Márcia Farias , Silvino Zenith Rosa , De Souza Cláudio José , Paiva Eny Dórea , Duarte Sabrina da Costa Machado , Reis Adriana Teixeira , De Oliveira Aline Silva da Fonte Santa Rosa 
Published: December 2024

Infográficos , definidos em Comunicação como textos multimodais , são exemplos de material instrucional cuja utilização em diversas áreas, incluindo a da saúde, tem crescido proporcionalmente ao desenvolvimento tecnológico por permitirem, a partir de uma apresentação pormenorizada, uma fácil compreensão dos processos que envolvam inovação tecnológica. Este estudo teve como objetivo elaborar material instrucional para treinamento/capacitação de enfermeiros em cateterismo epicutâneo neonatal auxiliado por ultrassonografia. Optou-se por uma abordagem qualitativa, aplicando o método de desenvolvimento de design instrucional. A escolha por infográficos foi motivada pelas facilidades de compreensão e divulgação em ambiente eletrônico. A roteirização dos conteúdos partiu de evidências mapeadas em uma revisão de escopo. Na fase de modelagem três softwares foram utilizados. Como resultado, quatro infográficos foram produzidos, contemplando recomendações atuais sobre a técnica estudada, didaticamente divididos em saber-fazer-gerenciar e saber-fazer-cuidar, obedecendo as etapas de inserção e manutenção do cateter. O material foi posteriormente condensado em versão animada, um produto capaz de fomentar a prática da utilização de recursos educacionais nos processos de ensino-aprendizagem de enfermeiros no cuidado qualificado a neonatos críticos. Sugerem-se novas pesquisas no âmbito do desenvolvimento de materiais instrucionais baseados em evidências, valiosos inclusive para aqueles que gerenciam as práticas de educação permanente.
Pendekatan Matematika yang Digunakan pada Biologi
Authors: Nur Vira Natasya  , Nutria Permadani  , Ikmawati Ikmawati  , Kurniawan Kurniawan  
Published: December 2024

Despite their apparent differences, mathematics and biology are increasingly being used in tandem to model and analyze a wide range of biological processes. This article addresses the use of multiple methods, including population modeling, differential equations, mathematical genetics, and epidemiology, to the study of biology, a field known as biomathematics. Genetic dynamics and the behavior of biological systems, such as population expansion and disease transmission, are understood through mathematical modeling. SIR and SEIR models are used in epidemiology to describe how infectious diseases spread throughout a population. This journal emphasizes the value of mathematical approaches in comprehending intricate biological systems and the necessity of interdisciplinary research between mathematics and biology to address both theoretical and practical issues through a review of the literature. The purpose of this article is to explain the relationship between mathematics and biology and the application of mathematical models in the analysis of biological phenomena. This article uses a literature study writing method by recording research problems, analyzing, and collaborating different thoughts.