bluuebunny/crossref_metadata_2025_split huggingface dataset:
Total Thrombus-Formation Analysis System (T-TAS): Clinical Application of Quantitative Analysis of Thrombus Formation in Cardiovascular Disease
Authors: Kaikita Koichi , Hosokawa Kazuya , Dahlen Jeffrey R. , Tsujita Kenichi 
Published: July 2019

AbstractVarious antithrombotic agents are clinically used to inhibit the cascade of arterial or venous thrombosis in cardiovascular diseases. Dual antiplatelet therapy with aspirin and P2Y12 inhibitors is prescribed in patients with coronary artery disease (CAD) undergoing percutaneous coronary intervention (PCI). Direct oral anticoagulants (DOACs) are widely used for the prevention or treatment of thromboembolism in patients with atrial fibrillation (AF) and venous thromboembolism. However, there has been no definitive tool to simultaneously monitor the antithrombotic effects of these drugs. The Total Thrombus-Formation Analysis System (T-TAS), a microchip-based flow chamber system that mimics in vivo conditions for evaluating whole blood thrombogenicity, was developed for the quantitative analysis of thrombus formation in whole blood specimens. The utility of T-TAS has been evaluated in CAD patients treated with antiplatelet therapies. The T-TAS PL chip area under the flow pressure curve (AUC) accurately assesses primary hemostasis and is sensitive to the therapeutic effects of various antiplatelet therapies. In addition, low AUC results are a significant predictor of periprocedural bleeding events in CAD patients undergoing PCI. The T-TAS AR chip AUC result is useful for assessing the efficacy of DOACs and warfarin in AF patients undergoing catheter ablation, and it is also a potential independent predictor of periprocedural bleeding events and avoidance of thrombosis in patients having undergone total knee arthroplasty. In conclusion, T-TAS is a useful index for evaluating the total antithrombotic effects of combination antithrombotic agents in patients with various cardiovascular diseases.
The space of coherence relations and their signalling in discourse
Authors: Taboada Maite 
Published: July 2019

AbstractI present an overview of the concept of coherence in discourse and explore how one of the essential elements to that coherence, relational coherence, has been studied and partitioned in different discourse traditions. I then introduce one of the theories that deals with discourse coherence, Rhetorical Structure Theory (RST). Through the description of RST, I investigate fundamental concepts in the study of coherence relations such as the classification of relations and their signalling in discourse.
Matthiessen on Halliday
Authors: Matthiessen Christian M. I. M. , Wang Bo , Ma Yuanyi 
Published: July 2019

AbstractChristian M. I. M. Matthiessen was a long-time collaborator and close friend of M. A. K. Halliday, and has co-authored various books with him, some of which have not yet been published. In this interview, he describes Halliday’s wide-ranging linguistic interests, provides details of Halliday’s time in China, discusses the influences of J. R. Firth and Karl Marx on Halliday, reflects on the development of Halliday’s theories, and describes Halliday’s contributions to phonetics, phonology and typology.
Regimes of voice and visibility in the refugeescape
Authors: Moriarty Máiréad 
Published: July 2019

AbstractThis paper proposesrefugeescapesas a framework for expanding the focus of semiotic landscape studies by centering migration, inequality, and social exclusion. In so doing, the article adds to the work ofMpendukana and Stroud (2018)andKerfoot and Hytlenstam (2017)in uncovering how place is structured by issues of affect, voice, and visibility. In my paper, I turn to a case study of the spatializing practices of refugees and asylum seekers in Ireland, and the ways they counteract the mainstream semiotic mediation of their experiences. In particular, I focus on the semiotic landscapes oftransgressive intentwhere asylum seekers address mistreatment in their host country. By examining material produced by refugees and asylum seekers themselves, my paper demonstrates how enclosed spaces are a methodological venue for the field, while arguing also for a more thorough engagement with the theory and politics of visibility/voice.
Succès et faiblesses de l’intégration des immigrants par la scolarisation obligatoire en français au
Québec
Authors: Paillé Michel 
Published: July 2019

Résumé
Centré sur la langue d’enseignement, ce bilan de la Charte de la langue française (loi
101) fait état de la connaissance, de l’apprentissage et de l’usage du français. Il montre que cette loi
s’est avérée très efficace pour conduire les enfants des immigrants dans les écoles françaises plutôt que dans celles du
réseau scolaire anglophone. Malgré cette réussite, illustrée par des comparaisons avec l’Ontario, l’anglais exerce
encore une forte attraction. C’est le cas notamment des jeunes qui, entreprenant des études collégiales, profitent d’une
pleine liberté pour poursuivre leurs études en anglais. L’auteur aborde également la politique de sélection d’immigrants
francophones, ainsi que le programme de francisation des immigrants ne connaissant pas le français. Absentes de la loi 101, ces
importantes mesures sont les éléments les plus faibles de la politique linguistique québécoise. Enfin, l’auteur constate
que l’apprentissage de l’anglais chez les francophones s’est poursuivi comme prévu, mais note que de
nombreux francophones bilingues s’expriment spontanément en anglais devant des personnes sachant pourtant parler français.
Inspiré par Max Weber, l’auteur conclut que « l’honneur linguistique » n’est pas encore au
rendez-vous.
Quebec’s language policy and economic globalization
Authors: Grenier Gilles 
Published: July 2019

Abstract
This article examines the economic situation of language groups in Quebec since the 1970s. Particular attention is
paid to the contexts of economic globalization, where English has become the most used world lingua franca, and of immigration now
being the major source of population growth. Viewing language as a market where supply and demand determine outcomes, the purpose
of Bill 101 was to increase the value and the use of French. The relative economic position of Francophones has improved and they
now have better purchasing power and control of the economy. However, the number of Francophones in the population is not expected
to increase much and their proportion in the population will drop significantly. Due to immigration, the number and proportion of
Allophones will increase, but Anglophones will also benefit since the proportion of immigrants who assimilate to English is larger
than the proportion of Anglophones in the population. In the labor market, working in English pays more than working in French for
immigrants. In spite of the progresses made by Francophones, the situation of French in Quebec remains a concern. The challenge is
to integrate more immigrants into the French-speaking majority.
Usage-based account of Italian Complex Prepositions denoting the Agent
Authors: Piunno Valentina , Ganfi Vittorio 
Published: July 2019

AbstractThis paper takes into account a particular set of Italian Complex Prepositions signaling the agent of an action (e.g.da parte di‘by’,a nome di‘by’). Italian exhibits several types of complex prepositions revealing a different involvement of the Agent: in particular, these complex lexemes can introduce and distinguish the participants who (i) plan and intentionally conceive an action, (ii) perform it and/or (iii) have a coercive power over its performing.The contribution aims to: (i) distinguish these Italian complex prepositions according to their functions, meanings, and the degree of involvement of the participant they introduce; (ii) analyze the collocational features and the syntactic environments where these lexemes occur; (iii) individuate possible correlations between their frequency of occurrence and the grammatical value; (iv) analyze their diachronic evolution across different historical phases; (v) put into relation the synchronic restrictions with the original syntactic environment within which the complex prepositions have been reanalyzed.
Evaluation of circulating small extracellular vesicles derived miRNAs as biomarkers of early colon cancer: a comparison with plasma total miRNAs
Authors: Min Li , Zhu Shengtao , Chen Lei , Liu Xiang , Wei Rui , Zhao Libo , Yang Yuqing , Zhang Zheng , Kong Guanyi , Li Peng , Zhang Shutian 
Published: July 2019

ABSTRACTEarly diagnosis of colon cancer (CC) is clinically important, as it can significantly improve patients' survival rate and quality of life. Although the potential role for small extracellular vesicles (sEVs) in early detection of many diseases has been repeatedly mentioned, systematic screening of plasma sEVs derived early CC specific biomarkers has not yet been reported. In this work, plasma sEVs enriched fractions were derived from 15 early‐stage (TisN0M0) CC patients and 10 normal controls (NC). RNA sequencing identified a total number of 95 sEVs enriched fraction derived miRNAs with differential expression between CC and NC, most of which (60/95) was in well accordance with tissue results in the Cancer Genome Atlas (TCGA) dataset. Among those miRNAs, we selected let‐7b‐3p, miR‐139‐3p, miR‐145‐3p, and miR‐150‐3p for further validation in an independent cohort consisting of 134 participants (58 CC and 76 NC). In the validation cohort, the AUC of 4 individual miRNAs ranged from 0.680 to 0.792. A logistic model combining two miRNAs (i.e. let‐7b‐3p and miR‐145‐3p) achieved an AUC of 0.901. Adding the 3rd miRNA into this model can further increase the AUC to 0.927. Side by side comparison revealed that sEVs miRNA profile outperformed cell‐free plasma miRNA in the diagnosis of early CC. In conclusion, we suggested that circulating sEVs enriched fractions have a distinct miRNA profile in CC patients, and sEVs derived miRNA could be used as a promising biomarker to detect CC at an early stage.
Overview of the FTU results
Authors: Pucella G. , Alessi E. , Angelini B. , Apicella M.L. , Apruzzese G. , Artaserse G. , Baiocchi B. , Belli F. , Bin W. , Bombarda F. , Boncagni L. , Botrugno A. , Briguglio S. , Bruschi A. , Buratti P. , Calabrò G. , Cappelli M. , Cardinali A. , Carnevale D. , Carraro L. , Castaldo C. , Causa F. , Ceccuzzi S. , Centioli C. , Cesario R. , Cianfarani C. , Claps G. , Cocilovo V. , Cordella F. , Crisanti F. , D’Arcangelo O. , De Angeli M. , Di Troia C. , Esposito B. , Fanale F. , Farina D. , Figini L. , Fogaccia G. , Frigione D. , Fusco V. , Gabellieri L. , Garavaglia S. , Giovannozzi E. , Gittini G. , Granucci G. , Grosso G. , Iafrati M. , Iannone F. , Laguardia L. , Lazzaro E. , Lontano M. , Maddaluno G. , Magagnino S. , Marinucci M. , Marocco D. , Mazzitelli G. , Mazzotta C. , Mellera V. , Milovanov A. , Minelli D. , Mirizzi F.C. , Moro A. , Nowak S. , Pacella D. , Pallotta F. , Panaccione L. , Panella M. , Pericoli-Ridolfini V. , Pizzuto A. , Podda S. , Puiatti M.E. , Ramogida G. , Ravera G. , Ricci D. , Romano A. , Simonetto A. , Sozzi C. , Tartari U. , Tuccillo A.A. , Tudisco O. , Valisa M. , Viola B. , Vitale E. , Vlad G. , Zeniol B. , Zerbini M. , Zonca F. , Aquilini M. , Cefali P. , Di Ferdinando E. , Di Giovenale S. , Giacomi G. , Grosso A. , Mezzacappa M. , Pensa A. , Petrolini P. , Piergotti V. , Raspante B. , Rocchi G. , Sibio A. , Tilia B. , Tulli R. , Vellucci M. , Zannetti D. , Almaviva S. , Bagnato F. , Brolatti G. , Buscarino A. , Calacci L. , Caneve L. , Carlini M. , Colao F. , Corradino C. , Costa P. , Crescenzi F. , Cucchiaro A. , Doria A. , Ferrò G. , Gabrielli A. , Galeani S. , Galperti C. , Gasior P. , Giovenale E. , Gospodarczyk M. , Jakubowski L. , Kubkowska M. , Lampasi A. , Lazic V. , Lubyako L. , Maffia G. , Martinelli F. , Martin Solis J.R. , Maviglia F. , Mazzuca R. , Moneti M. , Orsitto F.P. , Palucci A. , Passeri M. , Popovic Z. , Possieri C. , Rabinski M. , Ratynskaia S. , Reale M. , Roccella S. , Sassano M. , Starace F. , Tolias P. , Vertkov A. , Zebrowski J. , Zito P. 
Published: July 2019

Abstract
Since the 2016 IAEA Fusion Energy Conference, FTU operations have been mainly devoted to experiments on runaway electrons and investigations into a tin liquid limiter; other experiments have involved studies of elongated plasmas and dust. The tearing mode onset in the high density regime has been studied by means of the linear resistive code MARS, and the highly collisional regimes have been investigated. New diagnostics, such as a runaway electron imaging spectroscopy system for in-flight runaway studies and a triple Cherenkov probe for the measurement of escaping electrons, have been successfully installed and tested, and new capabilities of the collective Thomson scattering and the laser induced breakdown spectroscopy diagnostics have been explored.
Monitoring Akkuyu Nuclear Reactor Using Antineutrino Flux Measurement
Authors: Ozturk Sertac , Adiguzel Aytul , Erkcan Ozcan V. , Unel Gokhan 
Published: July 2019

Abstract
We present a simulation based study for monitoring Akkuyu Nuclear Power Plant’s activity using antineutrino flux originating from the reactor core. A water Cherenkov detector has been designed and optimization studies have been performed using Geant4 simulation toolkit. It was found that 1 ton of water Cherenkov detector with 0.3%-0.5% amount of gadolinium should be used for monitoring a nuclear reactor.
Comparison of Analytical Wake Models with Wind Tunnel Data
Authors: Campagnolo F , Molder A , Schreiber J , Bottasso C L 
Published: July 2019

Abstract
In this paper a comparison between the wake velocity, wake deflection and turbulence intensity predictions of several wake models was carried out against wind tunnel data obtained with a state-of-the-art scaled wind turbine model. In order to achieve a fair comparison, the models’ parameters were all tuned with respect to the same experimental dataset using the Maximum Likelihood Estimation (MLE) method. A quantitative assessment of all models’ predictions highlighted that the Porté-Agel model seems to provide, for a wide range of inflow and wind turbine operating conditions, the most accurate estimation of the wake flow field. Further improvements to the model are also suggested in the conclusions.
Impact of local meteorology on wake characteristics at Perdigão
Authors: Barthelmie R J , Pryor S C 
Published: July 2019

Abstract
During January – June 2017 a unique data set of Doppler lidar observations of a single wind turbine wake was collected within the Perdigão flow in complex terrain experiment conducted as part of the New European Wind Atlas. Over the six-month period, over 19,000 10- minute scans comprising a combination of; Arc Scans at ten elevation angles, Vertical Azimuth Display and Range Height Indicator scans were conducted. These data were subsequently analysed using a newly-developed automated wake identification and tracking algorithm. In total, over 1,900 ten-minute periods were identified as ‘wake periods’ by the algorithm, over 1000 with coherent wake centres. For these wakes, the detailed 3D volume of the wake characteristics are examined to assess the impact of different meteorological conditions on the magnitude and recovery of the velocity deficit in coherent wakes as they advect downwind.
Improved energy production of multi-rotor wind farms
Authors: van der Laan M.P. , Abkar M. 
Published: July 2019

Abstract
The multi-rotor (MR) wind turbine concept can be used to upscale wind turbines without increasing the rotor diameter, which can be beneficial for transport, manufacture and design of wind turbines blades. The rotor interaction of a MR wind turbine leads to a faster wake recovery compared to an equivalent single-rotor (SR) wind turbine wake. In this article, the benefit of the faster wake recovery of MR wind turbines is quantified using Reynolds-averaged Navier-Stokes simulations of a 4}4 rectangular MR wind farm, for three different inter wind turbine spacings. The simulations predict an increase of 0.3-1.7% in annual energy production for the MR wind farm with respect to an equivalent SR wind farm, where the highest gain is obtained for the tightest inter wind turbine spacing. The gain in AEP is mainly caused by the aligned wind directions for the first downstream wind turbine in a wind turbine row of the MR wind farm, which is verified by an additional large-eddy simulation.
Wake characteristics of pumping mode airborne wind energy systems
Authors: Haas T. , De Schutter J. , Diehl M. , Meyers J. 
Published: July 2019

Abstract
Airborne wind energy is an emerging technology that aims at harvesting wind power at high altitudes. In the present work, we propose a framework combining optimal control and large-eddy simulation to investigate the wake characteristics of large-scale airborne wind energy systems. We consider systems operating in pumping mode which alternate between power-generating and -consuming phases. We investigate the downstream wake development in non-turbulent and turbulent sheared inflow conditions. The optimal system operation leads to a non-uniform radial wake development and results show that the maximal wake velocity deficit for the current system is half the deficit predicted by Betz limit for a conventional wind turbine.
The Actuator Line Model in Lattice Boltzmann Frameworks: Numerical Sensitivity and Computational Performance
Authors: Asmuth Henrik , Olivares-Espinosa Hugo , Nilsson Karl , Ivanell Stefan 
Published: July 2019

Abstract
The growing use of large-eddy simulations for the modelling of wind farms makes the need for efficient numerical frameworks more essential than ever. GPU-accelerated implementations of the Lattice Boltzmann Method (LBM) have shown to provide significant performance gains over classical Navier-Stokes-based computational fluid dynamics. Yet, their use in the field of wind energy remains limited to date. In this fundamental study the cumulant LBM is scrutinised for actuator line simulations of wind turbines. The numerical sensitivity of the method in a simple uniform inflow is investigated with respect to spatial and temporal resolution as well as the width of the actuator line’s regularisation kernel. Comparable accuracy and slightly better stability properties are shown in relation to a standard Navier-Stokes implementation. The results indicate the overall suitability of the cumulant LBM for wind turbine wake simulations. The potential of the LBM for future wind energy applications is clarified by means of a brief comparison of computational performance.
Effects of Inflow Spatiotemporal Discretization on Wake Meandering and Turbine Structural Response using FAST.Farm
Authors: Shaler K. , Jonkman J. , Hamilton N. 
Published: July 2019

Abstract
FAST.Farm is a newly developed multiphysics, midfidelity engineering tool that can be used to predict turbine power and structural loads of wind turbines in a wind farm with minimal computational expense. Previous studies have shown similarities and differences in wind turbine performance between FAST.Farm and high-fidelity large-eddy simulations (LES) using both LES precursor-generated inflow and TurbSim-generated synthetic inflow. While conservative resolutions have been used to date, no formal spatial or temporal discretization study has been performed for the FAST.Farm model wind domains. This work aims to study the effects of varying the spatial and temporal discretization of the wind domains on wake meandering (low-resolution domain) and turbine structural response (high-resolution domains) and resulting wake and load calculations. The purpose of this study is to establish convergence criteria and recommendations for discretization values in terms of rotor diameter (D, expressed in meters) that will maximize computational efficiency. To ensure a percent error of ≤ 1% in standard deviation of wake center position relative to the finest included resolution, a low-resolution time step of 0.024D s, 0.016D s, and 0.0079D s and a low-resolution spatial discretization of 0.079D m, 0.16D m, and 0.24D m is recommended for 8 m/s, 12 m/s, and 18 m/s mean ambient wind speed at hub height, respectively. These guidelines are likely applicable to other implementations of the dynamic wake meandering model. To ensure a percent error of ≤ 1% in standard deviation of all considered structural response outputs, a high-resolution time step that captures the highest influential excitation and natural frequencies in the system and a high-resolution spatial discretization comparable to the maximum airfoil cord length is recommended. These guidelines are likely applicable to any aeroelastic analysis.
Effect of Coriolis force on a wind farm wake
Authors: Gadde Srinidhi Nagarada , Stevens Richard J.A.M. 
Published: July 2019

Abstract
The effect of the Coriolis force on the wake of a wind farm in a conventionally neutral and a stable boundary layer is investigated using large eddy simulations. We find that the average flow angle varies with the downstream position in the wind farm. In the entrance region of the wind farm, the flow blockage and wind veer create a positive gradient of the vertical flux

〈

u
′
w
′

¯

〉

at hub-height, which causes a counter-clockwise flow deflection in the Northern hemisphere, when observed from above. Further downstream, the vertical entrainment of air from the upper layers of the boundary layer generates a negative gradient of the vertical flux

〈

u
′
w
′

¯

〉

at hub-height, which results in a clockwise flow deflection in the Northern hemisphere. The deflection is more pronounced for the stable boundary layer than for the conventionally neutral boundary layer. In addition, we find that the wake deflection has a significant impact on the power production of turbines further downstream in the wind farm.
Lifetime extension of waked wind farms using active power control
Authors: Vali M , Petrović V , Pao L Y , Kühn M 
Published: July 2019

Abstract
This paper studies a new active power control (APC) of waked wind farms in order to extend the lifetime of highly loaded wind turbines. We demonstrate that the structural fatigue loading of a single turbine can be significantly alleviated, while the wind farm power production follows a power reference signal. Then, an optimization problem, subjected to a data-driven fatigue load model, is formulated to balance the lifetime fatigue loading of the wind turbines operating within a waked wind farm. A Game-Theoretic (GT) approach is employed to find a lifetime fraction, wherein a wind turbine should actively reject its own dynamic loadings due to turbulence. A large-eddy simulation model is employed for resolving the turbulent flow, the wake structures and its interaction with the atmospheric boundary layer. The applicability and key features of the controller are discussed with a wind farm example consisting of 2×2 turbines. The overall increase of wind farm lifetime is evaluated using the damage equivalent load (DEL) of the tower base fore-aft bending moment of the individual wind turbines.