bluuebunny/crossref_metadata_2025_split huggingface dataset:
During forearm rotation the three-dimensional ulnolunate distance is affected more by translation of the ulnar head than change in ulnar variance
Authors: Shin Seung-Han , Lee Yong-Suk , Choi Keun-Young , Kwak Dai-Soon , Chung Yang-Guk 
Published: September 2018

Ulnolunate abutment has been thought to be aggravated by pronation because of an increase in ulnar variance. We hypothesized that the ulnolunate distance might be greater in pronation because the ulnar head is dorsally translated. Twenty-one three-dimensional reconstructions of computed tomographic scans of wrists taken in supination and pronation were investigated. The ulnolunate distance was measured in each position, and the change in ulnolunate distance from supination to pronation was calculated. The changes in ulnar variance from supination to pronation and the amount of translation of the ulnar head were measured directly by superimposing three-dimensional reconstructions. The mean ulnolunate distance in pronation was significantly greater than in supination. There was no significant correlation between the changes in ulnolunate distance and in the ulnar variance. The change in ulnolunate distance had a significant positive linear relationship with the amount of translation of the ulnar head. The change in ulnolunate distance during forearm rotation is determined by the amount of translation of the ulnar head rather than by change in ulnar variance. Level of evidence: IV
Synthesis and Characterisation of Potentially Biodegradable Polyurethane Adhesives from Soybased Polyols
Authors: Orgilés-Calpena E. , Arán-Aís F. , Torró-Palau A.M. , Orgilés-Barceló C. 
Published: September 2018

Vegetable oils are one of the most important renewable raw materials because of their high availability and low price. Their use as a reagent for the synthesis of polymers represents many advantages such as biodegradability, low toxicity, sustainability, etc. The design of polymers from renewable resources is subject to increasing interest, specifically the development of biodegradable materials in order to reduce the dependence on petroleum and its negative impact on the environment. On the other hand, thanks to the versatility of polyurethane adhesives, they can be formulated by designing their properties through the selection of their reagents. This work focused on the development of potentially biodegradable polyurethane adhesives containing polyols from renewable resources, such as soy-based vegetable oils. Moreover, they were synthesised with 4,4'-diphenylmethane diisocyanate (MDI) and 1,4-butanediol as chain extender. The potentially biodegradable polyurethane adhesives were characterised by Fourier Transform Infrared Spectroscopy (FTIR), thermogravimetric tests (TGA), differential scanning calorimetry (DSC) and gel permeation chromatography (GPC). Finally, the adhesion properties were measured from a T-peel test of leather/polyurethane adhesive/SBR rubber joints, in order to establish the amount of polyol based on soybean oil that could be incorporated to synthesise polyurethane adhesives satisfactorily and meet the quality requirements for footwear.
Natural Fibre Reinforced Polymer Composite Materials - A Review
Authors: Dixit Savita , Goel Ritesh , Dubey Akash , Shivhare Prince Raj , Bhalavi Tanmay 
Published: September 2018

Availability of natural fibre, low cost and ease of manufacturing have urged the attention of researchers towards the possibility of reinforcement of natural fibre to improve their mechanical properties and study the extent to which they satisfy the required specifications of good reinforced polymer composite for industrial and structural applications. The chemically treated natural fibre shows better improvement in properties than untreated fibres. The chemically treated natural fibre has improved interfacial adhesion between fibre surface and polymer matrix. Natural fibre reinforcements have shown better results in impact toughness and fatigue strength. This review aims at explaining about the research and development in the improvement in properties of natural fibre reinforced polymer composites along with its application.
Postoperative Narcotic Prescription Practice in Orthopedic Foot and Ankle Surgery
Authors: Hearty Thomas M. , Butler Paul , Anderson John , Bohay Donald 
Published: September 2018

Background: The misuse and abuse of opioid pain medications have become a public health crisis. Because orthopedic surgeons are the third highest prescribers of opioids, understanding their postoperative pain medication prescribing practices is key to solving the opioid crisis. To this end, we conducted a study of the variability in orthopedic foot and ankle surgery postoperative opioid prescribing practice patterns. Methods: Three hundred fifty orthopedic foot and ankle surgeons were contacted; respondents completed a survey with 4 common patient scenarios and surgical procedures followed by questions regarding typical postoperative pain medication prescriptions. The scenarios ranged from minimally painful procedures to those that would be expected to be significantly more painful. Summaries were calculated as percentages and chi-square or Fisher exact tests were used to compare survey responses between groups stratified by years in practice and type of practice. Results: Sixty-four surgeons responded to the survey (92.8% male), 31% were in practice less than 5 years, 34% 6 to 15 years and 34% more than 15 years. For each scenario, there was variation in the type of pain medication prescribed ( scenario 1: 17% 5 mg hydrocodone, 22% 10 mg hydrocodone, 52% oxycodone, and 3% oxycodone sustained release [SR]; scenario 2: 15% 5 mg hydrocodone, 13% 10 mg hydrocodone, 58% oxycodone, and 9% oxycodone SR; scenario 3: 11% 5 mg hydrocodone, 13% 10 mg hydrocodone, 56% oxycodone, and 14.1% oxycodone SR; scenario 4: 3% 5 mg hydrocodone, 5% 10 mg hydrocodone, 44% oxycodone, and 45% oxycodone SR) and the number of pills dispensed. Use of multimodal pain management was variable but most physicians use regional nerve blocks for each scenario (76%, 87%, 69%, 94%). Less experienced surgeons (less than 5 years in practice) supplement with tramadol more for scenario 1 ( P = .034) as well as use regional nerve blocks for scenario 2 ( P = .039) more than experienced surgeons (more than 15 years in practice). Conclusion: It is evident that variation exists in narcotic prescription practices for postoperative pain management by orthopedic foot and ankle surgeons. With new AAOS guidelines, it is important to try to create some standardization in opioid prescription protocols.
Altered patterns of global protein synthesis and translational fidelity in RPS15-mutated chronic lymphocytic leukemia
Authors: Bretones Gabriel , Álvarez Miguel G. , Arango Javier R. , Rodríguez David , Nadeu Ferran , Prado Miguel A. , Valdés-Mas Rafael , Puente Diana A. , Paulo Joao A. , Delgado Julio , Villamor Neus , López-Guillermo Armando , Finley Daniel J. , Gygi Steven P. , Campo Elías , Quesada Víctor , López-Otín Carlos 
Published: September 2018

Abstract
Genomic studies have recently identified RPS15 as a new driver gene in aggressive and chemorefractory cases of chronic lymphocytic leukemia (CLL). RPS15 encodes a ribosomal protein whose conserved C-terminal domain extends into the decoding center of the ribosome. We demonstrate that mutations in highly conserved residues of this domain affect protein stability, by increasing its ubiquitin-mediated degradation, and cell-proliferation rates. On the other hand, we show that mutated RPS15 can be loaded into the ribosomes, directly impacting on global protein synthesis and/or translational fidelity in a mutation-specific manner. Quantitative mass spectrometry analyses suggest that RPS15 variants may induce additional alterations in the translational machinery, as well as a metabolic shift at the proteome level in HEK293T and MEC-1 cells. These results indicate that CLL-related RPS15 mutations might act following patterns known for other ribosomal diseases, likely switching from a hypo- to a hyperproliferative phenotype driven by mutated ribosomes. In this scenario, loss of translational fidelity causing altered cell proteostasis can be proposed as a new molecular mechanism involved in CLL pathobiology.
Notch signaling mediated by Delta-like ligands 1 and 4 controls the pathogenesis of chronic GVHD in mice
Authors: Radojcic Vedran , Paz Katelyn , Chung Jooho , Du Jing , Perkey Eric T. , Flynn Ryan , Ivcevic Sanja , Zaiken Michael , Friedman Ann , Yan Minhong , Pletneva Maria A. , Sarantopoulos Stefanie , Siebel Christian W. , Blazar Bruce R. , Maillard Ivan 
Published: September 2018

AbstractThere is a Blood Commentary on this article in this issue.
International, evidence-based consensus treatment guidelines for idiopathic multicentric Castleman disease
Authors: van Rhee Frits , Voorhees Peter , Dispenzieri Angela , Fosså Alexander , Srkalovic Gordan , Ide Makoto , Munshi Nikhil , Schey Stephen , Streetly Matthew , Pierson Sheila K. , Partridge Helen L. , Mukherjee Sudipto , Shilling Dustin , Stone Katie , Greenway Amy , Ruth Jason , Lechowicz Mary Jo , Chandrakasan Shanmuganathan , Jayanthan Raj , Jaffe Elaine S. , Leitch Heather , Pemmaraju Naveen , Chadburn Amy , Lim Megan S. , Elenitoba-Johnson Kojo S. , Krymskaya Vera , Goodman Aaron , Hoffmann Christian , Zinzani Pier Luigi , Ferrero Simone , Terriou Louis , Sato Yasuharu , Simpson David , Wong Raymond , Rossi Jean-Francois , Nasta Sunita , Yoshizaki Kazuyuki , Kurzrock Razelle , Uldrick Thomas S. , Casper Corey , Oksenhendler Eric , Fajgenbaum David C. 
Published: September 2018

Abstract
Castleman disease (CD) describes a group of heterogeneous hematologic disorders with characteristic histopathological features. CD can present with unicentric or multicentric (MCD) regions of lymph node enlargement. Some cases of MCD are caused by human herpesvirus-8 (HHV-8), whereas others are HHV-8–negative/idiopathic (iMCD). Treatment of iMCD is challenging, and outcomes can be poor because no uniform treatment guidelines exist, few systematic studies have been conducted, and no agreed upon response criteria have been described. The purpose of this paper is to establish consensus, evidence-based treatment guidelines based on the severity of iMCD to improve outcomes. An international Working Group of 42 experts from 10 countries was convened by the Castleman Disease Collaborative Network to establish consensus guidelines for the management of iMCD based on published literature, review of treatment effectiveness for 344 cases, and expert opinion. The anti–interleukin-6 monoclonal antibody siltuximab (or tocilizumab, if siltuximab is not available) with or without corticosteroids is the preferred first-line therapy for iMCD. In the most severe cases, adjuvant combination chemotherapy is recommended. Additional agents are recommended, tailored by disease severity, as second- and third-line therapies for treatment failures. Response criteria were formulated to facilitate the evaluation of treatment failure or success. These guidelines should help treating physicians to stratify patients based on disease severity in order to select the best available therapeutic option. An international registry for patients with CD (ACCELERATE, #NCT02817997) was established in October 2016 to collect patient outcomes to increase the evidence base for selection of therapies in the future.
The impact of robotic intervention on joint attention in children with autism spectrum disorders
Authors: Kumazaki Hirokazu , Yoshikawa Yuichiro , Yoshimura Yuko , Ikeda Takashi , Hasegawa Chiaki , Saito Daisuke N. , Tomiyama Sara , An Kyung-min , Shimaya Jiro , Ishiguro Hiroshi , Matsumoto Yoshio , Minabe Yoshio , Kikuchi Mitsuru 
Published: September 2018

Abstract
Background
A growing body of anecdotal evidence indicates that the use of robots may provide unique opportunities for assisting children with autism spectrum disorders (ASD). However, previous studies investigating the effects of interventions using robots on joint attention (JA) in children with ASD have shown insufficient results. The robots used in these studies could not turn their eyes, which was a limitation preventing the robot from resembling a human agent.

Methods
We compared the behavior of children with ASD with that of children with typical development (TD) during a JA elicitation task while the children interacted with either a human or a robotic agent. We used the robot “CommU,” which has clear eyes and can turn its eyes, for the robotic intervention. The age range of the participants was limited to 5–6 years.

Results
Sixty-eight participants participated in this study, including 30 (10 females and 20 males) children with ASD and 38 (13 females and 25 males) children with TD. The participants were randomly assigned to one of the following two groups: the robotic intervention group or the control group. JA in the children with ASD was better during the robotic intervention than during the human agent intervention. These children exhibited improved performance in the JA task with human after interacting with the robot CommU. JA was differentially facilitated by the human and robotic agents between the ASD and TD children.

Conclusions
The findings of this study significantly contribute to the literature on the impact of robots on JA and provide information regarding the suitability of specific robot types for therapeutic use.
Application of metabolomics to drug discovery and understanding the mechanisms of action of medicinal plants with anti‐tuberculosis activity
Authors: Tuyiringire Naasson , Tusubira Deusdedit , Munyampundu Jean‐Pierre , Tolo Casim Umba , Muvunyi Claude M. , Ogwang Patrick Engeu 
Published: September 2018

AbstractHuman tuberculosis (TB) is amongst the oldest and deadliest human bacterial diseases that pose major health, social and economic burden at a global level. Current regimens for TB treatment are lengthy, expensive and ineffective to emerging drug resistant strains. Thus, there is an urgent need for identification and development of novel TB drugs and drug regimens with comprehensive and specific mechanisms of action. Many medicinal plants are traditionally used for TB treatment. While some of their phytochemical composition has been elucidated, their mechanisms of action are not well understood. Insufficient knowledge on Mycobacterium tuberculosis (M.tb) biology and the complex nature of its infection limit the effectiveness of current screening‐based methods used for TB drug discovery. Nonetheless, application of metabolomics tools within the ‘omics’ approaches, could provide an alternative method of elucidating the mechanism of action of medicinal plants. Metabolomics aims at high throughput detection, quantification and identification of metabolites in biological samples. Changes in the concentration of specific metabolites in a biological sample indicate changes in the metabolic pathways. In this paper review and discuss novel methods that involve application of metabolomics to drug discovery and the understanding of mechanisms of action of medicinal plants with anti‐TB activity. Current knowledge on TB infection, anti‐TB drugs and mechanisms of action are also included. We further highlight metabolism of M. tuberculosis and the potential drug targets, as well as current approaches in the development of anti‐TB drugs.
Criminal background and job performance
Authors: Minor Dylan , Persico Nicola , Weiss Deborah M. 
Published: September 2018

Abstract
Job applicants with criminal records are much less likely than others to obtain legitimate employment. Recent efforts to address this problem include campaigns to persuade employers to hire applicants with a record voluntarily and legislation such as Ban the Box laws. The success of any remedial strategy depends on whether employer concerns are founded on an accurate view of how employees with a criminal background behave on the job if hired. Little empirical evidence now exists to answer this question. This paper attempts to fill this gap by examining firm-level hiring practices and worker-level performance outcomes. Our data indicate that individuals with criminal records have a much longer tenure and are less likely to quit their jobs voluntarily than other workers. Some results, however, differ by job: sales employees with a criminal record have a higher tendency than other workers to leave because of misconduct, while this effect is smaller and less significant for customer service workers. By examining psychometric data, we find evidence that bad outcomes for sales people with records may be driven by job rather than employee characteristics. We find some evidence that psychometric testing might provide a substitute for the use of criminal records, but that it would not in our own sample.
Prevalence of depression and anxiety in older patients with multiple myeloma in North Carolina: A population-based, claims-based assessment.
Authors: Copeland Anureet , Freeman Ashley , Baggett Christopher , Zhou Lei , Shea Thomas C. , Tuchman Sascha Alexander , Wood William Allen 
Published: September 2018

10048 Background: Patients (pts) with multiple myeloma (MM) experience physical symptoms and complications from disease or treatment that include bone pain, fatigue, anorexia, and insomnia. However, the prevalence of psychiatric comorbidities and their impact on short and long-term outcomes has been understudied. The aim of this analysis was to identify the prevalence of anxiety and depression in older pts with MM in the state of North Carolina. We also sought to evaluate if comorbid depression and anxiety impacted short and long-term outcomes in these patients. Methods: Using the University of North Carolina Integrated Cancer Information and Surveillance System (ICISS), we retrospectively identified a statewide cohort of 536 pts (ages 65-80) diagnosed with MM from 2006-2012 who had continuous enrollment in Medicare or Medicaid. Patients were identified through insurance claims by ICD-9 diagnosis codes for anxiety or depression or antidepressant medications filed at any time from 6 months prior to MM diagnosis to 12 months after MM diagnosis. Results: The mean age of pts in the cohort was 72 years. Pts were 68% non-Hispanic white, 42% rural, and 51% male. Of the 536 pts, 200 (37%) had a diagnosis of anxiety or depression and/or were being treated with an antidepressant. 54% of those with psychiatric comorbidity had a relevant diagnosis or medication in the 6 months prior to MM diagnosis. Of those with psychiatric comorbidities, 70% were diagnosed with fatigue and 57% were diagnosed with pain. In multivariate analysis, there was no association of psychiatric comorbidity with mortality (HR, 1.03; 95% CI, 0.83-1.28), but psychiatric comorbidity was associated with an increased likelihood of hospitalization or ER visit (RR, 1.17; 95% CI, 1.05-1.30) and increased opiate use within 1 year after diagnosis (RR, 1.66; 95% CI, 1.27-2.16). Conclusions: The presence of psychiatric comorbidity identifies a subset of older MM pts at risk for high symptom burden and increased health care utilization. The association of psychiatric comorbidity with increased opiate use in cancer pts may also have public health implications.
The impact of sleep disturbances (SD) on quality of life, psychological morbidity, and survival of advanced cancer patients (ACP) and caregivers (CG).
Authors: Hlubocky Fay J. , Sher Tamara , Cella David , Yap Bonnie J. , Ratain Mark J. , Peppercorn Jeffery , Daugherty Christopher 
Published: September 2018

10115 Background: SD have been described as a significant symptom burden for cancer patients and their caregivers. However, in advanced cancer, the prevalence of SD and its impact on the quality of life (QOL) and psychological morbidity of ACP over time has not been described. Methods: A prospective cohort of ACP participating in phase I trials was assessed at baseline (T1) and one month (T2) using psychosocial instruments: cognition (MMSE); depression(CES-D), state anxiety (STAI-S), QOL(FACIT-Pal), global health (SF-36). Semi-structured interviews evaluated SD patterns including: quality/latency, habitual efficiency, daytime dysfunction. Results: To date,152 subjects (76 ACP and 76 CG) have been separately interviewed at T1 and T2. For the total population: median age 61 (28-78y); 51% male; 100% married; 90% Ca; 64% > HS educ; 52% GI dx; 51% income < $65,000 yr; ACP median survival 7.9 months (0.41-18.2). At T1, 57% of ACP reported experiencing SD within the past week including: 55.6% insomnia, 44% nonrestorative sleep, 49% low energy, 48% daytime somnolence. For CG, 72% reported experiencing SD: 68% insomnia, 64% nonrestorative sleep, 69% fatigue, 66% daytime somnolence. At T2, rates remained consistent over time for both ACP and CG across time with the exception of increased insomnia at 61% and 76% respectively. After controlling for pain, mood, and fatigue, ACP with self-reported SD had higher STAI-S (33 ±11 v 29 ±8 , p = 0.02) and poor global health (54 ± 19 v. 64 ± 21, p = 0.01) at T2. CG with SD had higher STAI-S anxiety (39 ± 17 v 35 ± 13, p = 0.03) and poor global health (75 ±26 v 88±16, p = .0002) at T2.Regression analyses revealed ACP with self-reported insomnia had poorer FACIT-Pal QOL (59 ± 9 v 63 ± 10, p = 0.01) over time. Prior chemotherapy was associated with ACP SD (70% v. 33%, p = 0.02). Regarding prognosis, ACP with insomnia had shorter median survival (5.5 v. 7.2 months, p = 0.01). Conclusions: SD are prevalent among ACP participating in clinical trials and were associated with disease progression, QOL, and anxiety. Multidisciplinary supportive care interventions designed to address SD are warranted.
Impact of 2013 ASCO/CAP guidelines on HER2 determination of invasive breast cancer: A single institution experience using frontline dual-color FISH.
Authors: Gasparini Elisa , Ragazzi Moira , Bisagni Alessandra , Kuhn Elisabetta , Bassano Cristina , Tamagnini Ione , Foroni Moira , Falco Giuseppe , Ferrari Guglielmo , Braglia Luca , Savoldi Luisa , Bologna Alessandra , di Cicilia Roberto , Gardini Giorgio , Bisagni Giancarlo 
Published: September 2018

1028 Background: ASCO/CAP new guidelines published in 2013 (AC2013) significantly modified the scoring criteria for HER2-FISH. We retrospectively evaluated the impact of AC2013 in a five-year cohort of consecutive invasive breast cancers (IBCs) underwent frontline dual-color FISH. Furthermore, we applied three different reflex tests and investigated clinical outcomes of patients with HER2-equivocal IBC. Methods: 2788 consecutive IBCs that underwent frontline HER2/CEP17 determination in our institution from January 2009 to December 2013 were reclassified based on the AC2013 guidelines. FISH HER2-equivocal cases underwent reflex tests: HER2-IHC, RARA-FISH, and SMS-FISH. Clinico-pathological correlation was performed. Results: Two hundred HER2-negative cases (7.2%) were classified differently based on the AC2013: 0.3% (8/2788) became HER2-positive and 6.9% (192/2788) HER2-equivocal. AC2013 equivocal-IBCs represented a subgroup of grade 3, luminal-like subtype IBCs, in patients with a higher age. After reflex tests, among 190 equivocal cases 102 (53.7%) were reclassified as HER2-positive, 51 (26.8%) negative and 37 (19.5%) equivocal. IHC resulted negative in 44.7% (85), whereas SMS-FISH showed the highest percentage of positive results (45.8%). No statistically significant differences were identified in the disease-free and overall survival. Conclusions: AC2013 compared with AC2007 significantly increased initial HER2-equivocal cases (6.9%vs1.6%, p < 0.001). After reflex testing, 4.5% of patients not treated with anti-HER2 therapy (either HER2-positive or “ultimate equivocal”) resulted eligible to trastuzumab, but showed clinical outcome comparable with AC2007 HER2-positive patients, treated with trastuzumab. Our findings belittle the clinical impact of AC2013 HER2-equivocal reclassification; accordingly further studies are necessary to justify this category and the reclassification efforts by additional reflex tests.