bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fine-needle aspiration to diagnose primary thyroid lymphomas: a systematic review and meta-analysis
Authors: Zhang Lu , Castellana Marco , Virili Camilla , Crescenzi Anna , Giorgino Francesco , Zucca Emanuele , Ceriani Luca , Cavalli Franco , Giovanella Luca , Trimboli Pierpaolo 
Published: December 2018

Background
Primary thyroid lymphoma (PTL) is a rare malignancy, and its prognosis depends significantly on its early diagnosis. While fine-needle aspiration (FNA) represents the gold standard to identify differentiated thyroid carcinoma, its reliability for the detection of PTL is still unclear. Here, we conducted a systematic review and meta-analysis to evaluate the diagnostic performance of FNA in PTL.

Research design and methods
A comprehensive literature search of PubMed/MEDLINE and Scopus databases was conducted to retrieve papers reporting histologically proven PTL undergone FNA. The last search was performed in February 2018 without language and time restrictions.

Results
Thirty-two studies describing 593 PTL were included and the pooled FNA sensitivity was 0.48 (95% CI = 0.38–0.58). FNA sensitivity was 0.51 in 20 studies published before 2010 and 0.39 in those published later, 0.50 in six articles with at least 20 cases and 0.44 in nine series enrolled after 2000. This performance was similar in 12 articles including diffuse large B-cell lymphoma (0.54) and those six on marginal zone lymphoma (0.56). Remarkably, FNA sensitivity increased to 0.72 when considering also FNA reports suspicious for PTL reported in 14 articles. Heterogeneity among the series was found. Publication bias was not always detected.

Conclusions
The present meta-analysis demonstrated that FNA has low sensitivity in diagnosing PTL. However, this rate increased when considering also FNA reports suspicious for PTL, which is relevant from a clinical standpoint. This result could support indirectly the use of additional imaging and/or core biopsy when PTL is suspected.
Torsades de Pointes in Intravenous Drug Abuse–Associated Infective Endocarditis
Authors: Eapen Sarah , Firstenberg Michael 
Published: December 2018

Intravenous drug abuse rates in the United States have increased exponentially in recent years. Ohio is one of 5 states with the highest age-adjusted drug overdose death rates, with drug overdose causing 39.1 of every 100,000 deaths. In patients who survive, the associated morbidity poses a significant public health burden. Infective endocarditis, defined as an infection of the endocardium of the heart, is a potentially lethal consequence of bacteremia related to intravenous drug abuse. Methicillin-sensitive Staphylococcus aureus (MSSA) is the most commonly implicated organism and may affect the tricuspid valve. Indications for surgery include failure of medical management, worsening embolization, heart failure, and arrhythmias—typically bradyarrhythmias from infectious extension into the conduction system. Vegetation size and type of infection, such as drug-resistance pattern, fungal infection, and presence of prosthetic material, are becoming known risk factors for complications.
Studies have demonstrated that early surgery tends to have a better prognosis than delayed intervention. Established guidelines for right-sided surgery are slowly evolving. Tricuspid valve surgery is becoming more common in these cases, but there is known risk for heart block owing to proximity of the conduction system to the tricuspid valve annulus. If patients develop complete heart block postoperatively, pacemaker placement may be indicated. There may be reluctance to implantation because of the risk of device infection with infective endocarditis. In addition, many may recover conduction as infection and edema resolve. Generally, bradyarrhythmias are well tolerated. However, we present 2 cases of torsades de pointes related to post-tricuspid-valve-replacement bradyarrhythmia. Torsades de pointes is a potentially lethal form of polymorphic ventricular arrhythmia associated with QT interval prolongation. Post-tricuspid-valve- replacement mortality may be secondary to induced lethal ventricular arrhythmias.
A Strategy To Exploit Surrogate Sire Technology in Livestock Breeding Programs
Authors: Gottardo Paolo , Gorjanc Gregor , Battagin Mara , Gaynor R Chris , Jenko Janez , Ros-Freixedes Roger , Bruce A. Whitelaw C , Mileham Alan J , Herring William O , Hickey John M 
Published: December 2018

Abstract
In this work, we performed simulations to develop and test a strategy for exploiting surrogate sire technology in animal breeding programs. Surrogate sire technology allows the creation of males that lack their own germline cells, but have transplanted spermatogonial stem cells from donor males. With this technology, a single elite male donor could give rise to huge numbers of progeny, potentially as much as all the production animals in a particular time period. One hundred replicates of various scenarios were performed. Scenarios followed a common overall structure but differed in the strategy used to identify elite donors and how these donors were used in the product development part. The results of this study showed that using surrogate sire technology would significantly increase the genetic merit of commercial sires, by as much as 6.5 to 9.2 years’ worth of genetic gain compared to a conventional breeding program. The simulations suggested that a strategy involving three stages (an initial genomic test followed by two subsequent progeny tests) was the most effective of all the strategies tested. The use of one or a handful of elite donors to generate the production animals would be very different to current practice. While the results demonstrate the great potential of surrogate sire technology there are considerable risks but also other opportunities. Practical implementation of surrogate sire technology would need to account for these.
Mapping Neurotransmitter Identity in the Whole-Mount Drosophila Brain Using Multiplex High-Throughput Fluorescence in Situ Hybridization
Authors: Meissner Geoffrey W , Nern Aljoscha , Singer Robert H , Wong Allan M , Malkesman Oz , Long Xi 
Published: December 2018

Abstract
Identifying the neurotransmitters used by specific neurons is a critical step in understanding the function of neural circuits. However, methods for the consistent and efficient detection of neurotransmitter markers remain limited. Fluorescence in situ hybridization (FISH) enables direct labeling of type-specific mRNA in neurons. Recent advances in FISH allow this technique to be carried out in intact tissue samples such as whole-mount Drosophila melanogaster brains. Here, we present a FISH platform for high-throughput detection of eight common neurotransmitter phenotypes in Drosophila brains. We greatly increase FISH throughput by processing samples mounted on coverslips and optimizing fluorophore choice for each probe to facilitate multiplexing. As application examples, we demonstrate cases of neurotransmitter coexpression, reveal neurotransmitter phenotypes of specific cell types, and explore the onset of neurotransmitter expression in the developing optic lobe. Beyond neurotransmitter markers, our protocols can in principle be used for large-scale FISH detection of any mRNA in whole-mount fly brains.
Use of a Clinical Care Algorithm to Improve Care for Children With Hematogenous Osteomyelitis
Authors: Robinette Eric D. , Brower Laura , Schaffzin Joshua K. , Whitlock Patrick , Shah Samir S. , Connelly Beverly ,   on behalf of the AHO Care Algorithm Team
Published: December 2018

BACKGROUND AND OBJECTIVES:
Acute hematogenous osteomyelitis (AHO) causes significant morbidity in children. Quality improvement (QI) methods have been used to successfully improve care and decrease costs through standardization for numerous conditions, including pediatric AHO. We embarked on a QI initiative to standardize our approach to the inpatient management of AHO, with a global aim of reducing inpatient costs.

METHODS:
We used existing literature and local consensus to develop a care algorithm for the inpatient management of AHO. We used the Model for Improvement as the framework for the project, which included process mapping, failure mode analysis, and key driver identification. We engaged with institutional providers to achieve at least 80% consensus regarding specific key drivers and tested various interventions to support uptake of the care algorithm.

RESULTS:
Fifty-seven patients were included. There were 31 patients in the preintervention cohort and 26 in the postintervention cohort, of whom 19 were managed per the algorithm. Mean inpatient charges decreased from $45 718 in the preintervention cohort to $32 895 in the postintervention cohort; length of stay did not change. Adherence to recommended empirical antimicrobial agents trended upward.

CONCLUSIONS:
A simple and low-cost QI project was used to safely decrease the cost of inpatient care for pediatric AHO at a tertiary care children’s hospital. A robust local consensus process proved to be a key component in the uptake of standardization.
Development and application of a respiratory device on blood pressure in adults with high blood pressure
Authors: Yuenyongchaiwat Kornanong , Thanawattano Chusak , Buranapuntalug Sasipa , Pongpanit Khajonsak , Saengkrut Patcharin 
Published: December 2018

Purpose
The purpose of this study is to develop a prototype of a novel respiratory device that we validated and assessed clinically and examined the effect of prototype of respiratory device on blood pressure (BP).

Methods
Prototype of respiratory device (TU-Breath Training) was designed with pressure cuff and application software was created. The immediate effect of resisted breathing was determined in 20 adults with high BP (systolic BP ≥ 130 mmHg and diastolic BP ≥ 90 mmHg). A crossover study was designed. A total of 20 eligible participants were asked to sit quietly for 10 min. Heart rate (HR), BP, and oxygen saturation (SpO2) were measured and recorded. After the resting period, all participants were randomized and counterbalanced for undergoing the set of inspiratory muscle training by TU-Breath Training and control group. A set of respiratory training were composed of 10 times per set for three sets, while the control group was asked to sit for 10 min.

Results
After inspiratory training, both the systolic and diastolic BP decreased significantly. Compared with control group, using TU-Breath Training decreased systolic BP (−7.00 ± 5.93 mmHg) and diastolic BP (−5.95 ± 8.88 mmHg), but did not show differences in HR and SpO2.

Conclusion
The study indicated that in high-BP participants, the prototype of respiratory device (TU-Breath Training) elicits decreased BP.
Pulmonary complications of predominantly antibody immunodeficiencies in a tertiary lung center
Authors: Mahdaviani Seyed Alireza , Darougar Sepideh , Mansouri Davood , Tashayoie-Nejad Sabereh , Movahedi Mahshid , Aghdam Karim Rahimi , Ghaffaripour Hosseinali , Baghaie Nooshin , Hassanzad Maryam , Eslaminejad Alireza , Fakharian Atefeh , Pourdowlat Guitti , Heshmatnia Jalal , Bakhshayeshkaram Mehrdad , Boloursaz Mohammadreza , Tabarsi Payam , Hashemitari Seyed Karen , Velayati Ali Akbar 
Published: December 2018

Background and aims
Respiratory infections are expressed very soon in the life in humoral immunodeficiencies and often lead to chronic irreversible complications such as bronchiectasis and chronic airflow limitation. This study was conducted to evaluate the pulmonary complications of predominantly antibody immunodeficiencies to show the benefits of timely diagnosis and appropriate therapy.

Patients and methods
The information of 48 patients involved with a type of predominantly antibody immunodeficiencies, including sex, type of primary immunodeficiency, age at the onset of symptoms, age at diagnosis, recurrent infections, respiratory symptoms, and pulmonary radiological and functional abnormalities were recorded and analyzed.

Results
In 48 patients evaluated, the mean age at diagnosis was 25.63 years. The mean diagnostic delay was estimated to be 13.62 years. The most recurring clinical manifestations, sinusitis (69.6%), otitis (43.5%), and recurrent pneumonia were the cause of frequent admissions in 68.8% of these patients. Bronchiectasis was frequently found (58.3%) in these patients mostly involving the middle and lower lobes (48.8% and 41.5%, respectively).

Conclusions
Respiratory complications, infectious or non-infectious, determine the prognosis of the disease in patients with predominantly antibody immunodeficiencies. Timely diagnosis and appropriate management may improve life expectancy and the quality of life in these patients.
PARENTAL ALIENATION WITHIN THE CONTEXT OF THE 1980 HAGUE CONVENTION ON THE CIVIL ASPECTS OF INTERNATIONAL CHILD ABDUCTION: THE BRAZILIAN PERSPECTIVE
Authors: Almeida Bruno Rodrigues de , Vidal Gisela Vieira Dalfeor 
Published: December 2018

The number of cases of relocation of children and adolescents to Brazil has increased significantly in the last years. One must consider that abducting or wrongfully retaining children from the places of their habitual residence prevents them from enjoying fundamental rights such as those to historical, social and cultural identities and even the right enjoy full family life with both sides of their families. This article shows that unilateral relocation of children to Brazil (as well their wrongful retention in Brazilian territory) in violation of the 1980 Hague Convention on the Civil Aspects of International Child Abduction, is actually one form of Parental Alienation practiced in cross border circumstances, pursuant to Federal Law nº 12.318, from August 26, 2010 (Brazilian Parental Alienation Act). On that sense, Brazilian administrative and judicial authorities must not only engender public policies and strategies to enhance acknowledgement about rules of the Convention among Brazilian communities living abroad, they must also encourage extrajudicial agreements between interested parties to increase the rates of voluntary return of abducted or retained children. In cases brought to courts, since Parental Alienation is a form of emotional abuse of the child, magistrates must count on the opinion of interdisciplinary advisors before considering opinion of the abducted children in the ruling of the return order. In sum, the search for international cooperation with other Contracting States of the 1980 Hague Convention and the respect of the best interest of the child must be in permanent harmony.
En un país muy lejano: tematización de Marruecos en la literatura española escrita por mujeres = In a faraway land: theming of Morocco in Spanish literature written by women.
Authors: Romero Morales Yasmina 
Published: December 2018

El presente trabajo tiene como propósito detenerse en las características del Marruecos literario de la narrativa española de ficción escrita por mujeres durante el siglo XX. Un conjunto de sesenta y dos textos, y casi cinco mil páginas, que desarrollan su acción en el espacio marroquí, emplazamiento principal de sus tramas y componente que las engarza a todas. La lectura del espacio geográfico de estas fuentes nos devuelve un Marruecos imaginado por las autoras en el que destacan unas especiales conexiones de las coordenadas espacio-temporales a las que se aproximarán las próximas páginas. This present work has the purpose to stop the characteristics of the literary Morocco of the Spanishnarrative of fiction written by women during the twentieth century. A set of sixty-two texts, and nearlyfive thousand pages, which develop their action in the Moroccan space, main location of their storylinesand components that connect them all. Reading the geographical space of these sources it returns tous Morocco imagined by the women authors in which it emphasizes special connections time-space towhich the following pages will approach.
Creating Dangerously
Authors: DeMeulenaere Eric 
Published: December 2018

Universities and scholars have long wrestled with the types of impact they want their work to have on the world. This narrative explores the challenge of impact from the perspective of a recently tenured professor reflecting on his case for tenure and his struggle to fit his activist scholarship within the genre of the tenure case, which requires candidates to explain their work and its impact. Through an examination of this struggle, the author identifies three challenges that universities need to confront if they want to enable more community-engaged scholarship: 1) The problem of expertise, 2) the problem of genre, and 3) the problem of focus. If and when the academy begins to address these challenges, the author argues, activist scholars will no longer have to hide the nature of their community engaged work and their scholarship will be able to better reach larger audiences beyond the academy.
On Some Problems for a Simplex and a Ball in R<sup>n</sup>
Authors: Nevskii Mikhail V. 
Published: December 2018

Let \(C\) be a convex body and let \(S\) be a nondegenerate simplex in \({\mathbb R}^n\). Denote by \(\tau S\) the image of \(S\) under homothety with a center of homothety in the center of gravity of \(S\) and the ratio \(\tau\). We mean by \(\xi(C;S)\) the minimal \(\tau>0\) such that \(C\) is a subset of the simplex \(\tau S\). Define \(\alpha(C;S)\) as the minimal \(\tau>0\) such that \(C\) is contained in a translate of \(\tau S\). Earlier the author has proved the equalities \(\xi(C;S)=(n+1)\max\limits_{1\leq j\leq n+1}\max\limits_{x\in C}(-\lambda_j(x))+1\) (if \(C\not\subset S\)), \(\alpha(C;S)=\sum\limits_{j=1}^{n+1} \max\limits_{x\in C} (-\lambda_j(x))+1.\)Here \(\lambda_j\) are the linear functions that are called the basic Lagrange polynomials corresponding to \(S\). The numbers \(\lambda_j(x),\ldots, \lambda_{n+1}(x)\) are the barycentric coordinates of a point \(x\in{\mathbb R}^n\). In his previous papers, the author investigated these formulae in the case when \(C\) is the \(n\)-dimensional unit cube \(Q_n=[0,1]^n\). The present paper is related to the case when \(C\) coincides with the unit Euclidean ball \(B_n=\{x: \|x\|\leq 1\},\) where \(\|x\|=\left(\sum\limits_{i=1}^n x_i^2 \right)^{1/2}.\) We establish various relations for \(\xi(B_n;S)\) and \(\alpha(B_n;S)\), as well as we give their geometric interpretation. For example, if \(\lambda_j(x)=l_{1j}x_1+\ldots+l_{nj}x_n+l_{n+1,j},\) then \(\alpha(B_n;S)=\sum\limits_{j=1}^{n+1}\left(\sum\limits_{i=1}^n l_{ij}^2\right)^{1/2}\). The minimal possible value of each characteristics \(\xi(B_n;S)\) and \(\alpha(B_n;S)\) for \(S\subset B_n\) is equal to \(n\). This value corresponds to a regular simplex inscribed into \(B_n\). Also we compare our results with those obtained in the case \(C=Q_n\).
Noninvasive Ventilation and High-Flow Nasal Cannulae Therapy for Children with Acute Respiratory Failure: An overview
Authors: Al-Mukhaini Khaloud S. , Al-Rahbi Najwa M. 
Published: December 2018

Noninvasive ventilation (NIV) refers to the use of techniques to deliver artificial respiration to the lungs without the need for endotracheal intubation. As NIV has proven beneficial in comparison to invasive mechanical ventilation, it has become the optimal modality for initial respiratory support among children in respiratory distress. High-flow nasal cannulae (HFNC) therapy is a relatively new NIV modality and is used for similar indications. This review discusses the usefulness and applications of conventional NIV in comparison to HFNC.Keywords: Noninvasive Ventilation; Nasal Cannulae; Endotracheal Intubation; Mechanical Ventilation; Children.
Attitudes Towards and Perceptions Regarding the Implementation of Evidence-Based Practice Among Omani Nurses
Authors: Al-Maskari Mohammed A. , Patterson Barbara J. 
Published: December 2018

Objectives: This study aimed to explore the attitudes of Omani nurses towards evidence-based practice (EBP) and their perceptions of the barriers to and facilitators of EBP implementation in Oman. In addition, the attitudes and perceptions of nurse leaders and staff nurses were compared. Methods: This descriptive cross-sectional study was conducted between August and October 2016 in three suburban governmental hospitals in Northern Oman. A demographic questionnaire and two EBP instruments were used to collect data from 282 registered Omani nurses, including the Evidence-Based Nursing Attitude Questionnaire and the Developing Evidence-Based Practice Questionnaire. Results: A total of 260 Omani nurses took part in the study (response rate: 92.2%). On the whole, the nurses had positive attitudes towards EBP, with no significant difference in mean attitude scores per item between staff nurses and nurse leaders (3.98 ± 0.46 versus 4.03 ± 0.50; P = 0.431). However, in comparison to staff nurses, nurse leaders had higher scores per item for the barriers to changing practice and finding and reviewing evidence subsections, with lower scores for the facilitators to changing practice section. Conclusion: In accordance with the international literature, Omani nurses had positive attitudes towards EBP as well as similar perceptions of barriers and facilitators to EBP implementation. These findings may help to inform recommendations for the integration of EBP in educational programmes and clinical settings in Oman, as well as to facilitate necessary changes in nursing practice.Keywords: Evidence-Based Practice; Nurses; Attitudes; Perceptions; Oman.
Association Between Voice Handicap Index and Reflux Symptom Index: A cross-sectional study of undiagnosed general and teacher cohorts in Saudi Arabia
Authors: Alanazi Rawan , Alrahim Ahmed , Bayounos Sara , Al-Ghuwainem Abdulrahman , Al-Bar Mohammad H. 
Published: December 2018

Objectives: This study aimed to assess potential associations between self-reported symptoms of laryngopharyngeal reflux (LPR) and voice disorders among two undiagnosed cohorts in Saudi Arabia. Methods: This cross-sectional study was conducted from February to April 2017 in Khobar, Saudi Arabia. Validated Arabic versions of the Reflux Symptom Index (RSI) and 10-item Voice Handicap Index (VHI-10) were distributed to 400 teachers at 13 schools and 300 members of the general population attending an ear, nose and throat clinic in Khobar. Scores of >13 and >11 on the RSI and VHI-10 indicated a potential subjective diagnosis of LPR and voice disorders, respectively. Results: A total of 446 individuals took part in the study, including 260 members of the general population (response rate: 86.7%) and 186 teachers (response rate: 46.5%). The mean age was 32.5 years. In total, 62.2% complained of voice and/or reflux problems, with the remaining 37.8% not reporting/unaware of any problems in this regard. Among the teachers, 30.6% and 18.3% had positive RSI and VHI-10 scores, respectively, while 43.1% and 14.6% of the individuals from the general population had positive RSI and VHI-10 scores, respectively. Overall, VHI-10 scores were significantly associated with RSI scores (P <0.001). Conclusion: A significant association between RSI and VHI-10 scores suggests that there may be an association between LPR and voice disorders. These tools would therefore be a valuable method of monitoring patients; however, they cannot be used to confirm a diagnosis. Thus, more detailed studies are needed to confirm this association using a larger sample size.Keywords: Voice Disorders; Laryngopharyngeal Reflux; Hoarseness; Diagnostic Self Evaluation; School Teachers; Saudi Arabia.