bluuebunny/crossref_metadata_2025_split huggingface dataset:
Normal observers show no evidence for blindsight in facial emotion perception
Authors: Rajananda Sivananda , Zhu Jeanette , Peters Megan A.K. 
Published: May 2018

AbstractIt is commonly assumed that normal human observers can exhibit ‘blindsight-like’ behavior: the ability to discriminate or identify a stimulus without being aware of it. However, we recently used a bias-free task to show that what looks like blindsight may in fact be an artifact of typical experimental paradigms’ susceptibility to response bias. While those findings challenge many previous reports of blindsight in normal observers, they do not rule out the possibility that different stimuli or techniques could reveal such perception without awareness. One particularly intriguing candidate for this unconscious perception is emotion processing, as processing of emotional stimuli (e.g. fearful/happy faces) has been reported to potentially bypass conscious visual circuits. Here we used the bias-free blindsight paradigm to investigate whether emotion processing might reveal ‘featural blindsight’, i.e. the ability to identify a face’s emotion without having introspective access to the task-relevant features of the face that led to the discrimination decision. However, despite the purported ability of emotional stimuli to bypass conscious visual processing, we saw no evidence for such emotion processing ‘featural blindsight’: like in our previous study, as soon as participants could identify a face’s emotion they reported introspective access to the task-relevant features, matching predictions of a Bayesian ideal observer. The present results challenge dominant theory, adding to the growing body of evidence that perceptual discrimination ability in the complete absence of introspective access may not be possible for neurologically intact observers.
Identification of novel and structurally diverse N-Methyl-D-Aspartate Receptor Antagonists: Successful Application of Pharmacophore Modeling, Virtual Screening and Molecular Docking
Authors: Sharma Mukta , Mittal Anupama , Singh Aarti , Jainarayanan Ashwin K. , Paliwal Sarvesh Kumar 
Published: May 2018

ABSTRACTIn view of “excitotoxic” effects of glutamate, wherein excessive excitatory input causes increase in intracellular Ca2+ and ultimately cell death, NMDA receptor has emerged as an important target for treatment and prevention of several neurological disorders, like Alzheimer disease. Prompted by the successful application of in-silico pharmacophore-based virtual screening in lead identification, we have made an effort to implement in-silico protocols to identify novel NMDA receptor antagonist. A series of novel benzo[b]quinolizinium cations as NMDA receptor antagonists have been used as a starting point to develop prognostic pharmacophore models. The most predictive pharmacophore model (hypothesis 1), consisting of four features, namely, one hydrogen bond acceptor, one hydrophobic and two ring aromatic, showed a correlation (r) of 0.89, root mean square of 0.259, and the cost difference of 43.01 bits between null and fixed cost. The model was thoroughly validated and subjected to a chemical database search, which lead to the identification of 400 hits from NCI and Maybridge databases which were checked for Lipinski’s violation and predictive potency.This reduced the list to 10 compounds, out of which, two most potent compounds were subjected to molecular docking using Libdock software and interestingly, all the docked conformations showed hydrogen bond interactions with important amino acids Tyr214, His88, Thr174, Val169 and Arg121. In summary, through our validated pharmacophore-based virtual screening protocol, we have identified two potent, structurally diverse, druggable and novel NMDA receptor antagonist which might be of great help to address the unmet medical need of Alzheimer disease.
A cosine similarity-based method to infer variability of chromatin accessibility at the single-cell level
Authors: Cai Stanley , Georgakilas Georgios K. , Johnson John L. , Vahedi Golnaz 
Published: May 2018

AbstractCellular identity between generations of developing cells is propagated through the epigenome particularly via the accessible parts of the chromatin. It is now possible to measure chromatin accessibility at single-cell resolution using single-cell assay for transposase accessible chromatin (scATAC-seq), which can reveal the regulatory variation behind the phenotypic variation. However, single-cell chromatin accessibility data are sparse, binary, and high dimensional, leading to unique computational challenges. To overcome these difficulties, we developed PRISM a computational workflow and R package (https://github.com/stanleycai123/PRISM) that quantifies cell-to-cell chromatin accessibility variation while controlling for technical biases. Using data generated in our lab or publically available, we show that PRISM outperforms an existing algorithm, which relies on the aggregate of signal across a set of genomic regions. PRISM shows robustness to noise in low accessibility cells and reveals previously masked accessibility variation where accessible sites differ between cells but total number of accessible sites is constant. We also show that PRISM, but not an existing algorithm, finds suppressed heterogeneity of accessibility at CTCF binding sites. PRISM is a novel multidimensional scaling-based method using angular cosine distance metrics coupled with distance from the spatial centroid. PRISM takes differences in accessibility at each genomic region between single cells into account. This updated approach uncovers new biological results with profound implications on the cellular heterogeneity of chromatin architecture.
Introduction: cultivation, medication, activism and cannabis policy
Authors: Bone Melissa , Potter Gary , Klein Axel 
Published: May 2018

Purpose
The purpose of this paper is to introduce the special issue on Illicit Cannabis Cultivation in a Time of Policy Change.

Design/methodology/approach
The paper reviews some of the different adaptations made by cannabis growers in countries where cannabis has not been legalised.

Findings
Cannabis growers are adjusting to different legal settings by focusing on home production. Participation in cultivation is a crime, but can also be activism: an effort to change the law. Medical use of cannabis is a particularly important driver here. Having to break the law to alleviate symptoms and treat illnesses provides both a greater sense of urgency and a level of sympathy not usually granted to illicit drug users.

Practical implications
Grass-roots advocacy may drive policy change.

Originality/value
This is an original assessment of current state of knowledge on cannabis cultivation in countries where cannabis cultivation remains restricted.
Academic consulting – income stream, impact and brand building
Authors: Kinnunen Heidi , Holm Emmi , Nordman Anna-Maria , Roschier Solveig 
Published: May 2018

PurposeUniversities are expected to accelerate and optimize their role as economic growth engines. Technology transfer is a traditional way of expanding knowledge exchange, and it is typically used in hard sciences. This paper aims to discuss academic consultancy as a novel way to bring especially social sciences, humanities and arts (SSHA sciences) knowledge into the society. In addition, it seeks practical ways to combine both university’s and individual researcher’s needs in consultancy.Design/methodology/approachA case study comprising interviews at two Finnish universities was conducted. Literature on academic consulting was used as background knowledge. International benchmarking was done through interviews and desk top studies. Some background statistics was extracted from the financial database for received research funding from businesses and ministries.FindingsCorporate funding is most prominent in hard sciences, and SSHA sciences seem to get their funding mainly from public sources. SSHA researchers provide services for firms, but these relationships are generally private. According to interviews, there is will to consult firms through university, but researcher’s time limitations, remuneration and academic merit related to consultancy are important factors when consultancy guidelines are drawn. The administration view is expanded from only research staff to include the entire university knowledge production ecosystem and its members.Originality/valueAcknowledging the value of SSHA sciences is topical because the respect towards humanities and social studies seems to be in decline in some developed countries. However, according to this study, academic consulting could have great potential in bringing the human perspective into the digitalized society. The quantification of knowledge exchange would benefit from formal, institutionalized consultancy sales. More studies are needed to assess the impact of academic consultancy on society.
Curricular coaches’ impact on retention for early-career elementary teachers in the USA
Authors: De Jong David , Campoli Ayana 
Published: May 2018

PurposeResearchers have found that curricular coaches have had an impact on student achievement by supporting classroom teachers in providing high-quality instruction. However, few studies examine the association between curricular coaches and teacher retention, especially in urban areas. Given the high cost of teacher turnover and the high percentage of early-career teachers who leave the profession each year, the purpose of this paper is to investigate whether the presence of curricular coaches in elementary schools reduces turnover among early-career teachers.Design/methodology/approachIn this study, the authors analyzed the observational data from the 2007-2008 Schools and Staffing Survey (SASS). The SASS is a nationally representative cross-sectional survey that has been administered repeatedly to public and private kindergarten through 12th-grade teachers in the USA approximately every four years by the National Center for Education Statistics and the US Census Bureau.FindingsThe authors found that the presence of a curricular coach was associated with a substantial reduction in early-career teacher turnover. This finding suggests that curricular coaches could be a particular benefit to urban schools.Research limitations/implicationsThis study was national in scope; therefore, it does not examine causes of attrition specific to local contexts.Practical implicationsCurricular coaches may indirectly save urban school districts thousands of dollars because of their impact on reducing early-career teacher attrition.Social implicationsIn this study, the authors found a statistically significant and practically meaningful association between the presence of curricular coaches in schools and the retention of elementary teachers, especially in urban areas.Originality/valueThe model predicted that among early-career teachers, teachers in schools without curricular coaches are approximately twice as likely to leave the profession the next year compared to teachers in schools with curricular coaches.
The winery experience from the perspective of Generation Z
Authors: Stergiou Dimitrios P. , Airey David , Apostolakis Alexandros 
Published: May 2018

PurposeThe purpose of this paper is to investigate the wine tourism experience from the perspective of Generation Z adults in Greece, following an actual winery visit.Design/methodology/approachResponses were obtained from a total of 306 respondents drawn from student groups visiting a winery in the Achaia region of the Peloponnese, Western Greece, using convenience sampling. A list of winescape attributes was adopted for testing and used to structure self-administered questionnaires. The data collected were analysed using a factor-analytic and importance-performance analysis framework.FindingsFive factors that promote understanding of the desired wine tourism experience of Generation Z adults were identified, namely, cost considerations and wine and entertainment both perceived to be important but the winery’s performance on the same was poor, destination attributes and service staff both perceived to be important with good performance and learning about wine perceived to be unimportant with low performance.Originality/valueThis is the first academic study focusing specifically on the winery experience from the perspective of Generation Z. As such, it has provided new and useful insights for researchers and managers in the wine industry concerning the experience of this under-researched generational cohort.
The relationship between authentic leaders and employees’ creativity
Authors: Semedo Ana Suzete , Coelho Arnaldo , Ribeiro Neuza 
Published: May 2018

PurposeThe purpose of this paper is to investigate how authentic leadership (AL) predicts creativity both directly and through the mediating role of affective commitment (AC) and job resourcefulness (JR).Design/methodology/approachData collected from a questionnaire administered to a sample of 543 employees have been analyzed. The model was tested using structural equation modeling.FindingsThe findings show that AL predicts AC, JR and creativity. The findings also show that AC and JR predict creativity. In other words, leaders’ authenticity increases employees’ creative spirit and, thus, employees’ ability to overcome obstacles and meet challenges at work and their emotional bond play an important role (mediators) in this relationship.Practical implicationsThe results of this study are conclusive and contribute to a better understanding of AL and its implication for employees’ emotional bond, their ability to overcome obstacles and their ability to introduce new and useful ideas. This study provides evidence that organizations should focus on training leaders with authentic characteristics.Originality/valueThis study considers both AC and JR as mediators of the relationship between AL and creativity. Therefore, the originality of this study lies in the integration of these four concepts in a single study to provide a model that depicts the chain of effects between AL, AC, JR and an employee’s creativity.
Mapping the “housing with care” concept with stakeholders: insights from a UK case study
Authors: Wild Annie , Clelland David , Whitelaw Sandy , Fraser Sandy , Clark David 
Published: May 2018

Purpose
The purpose of this paper is to present the findings of an early stage, exploratory case study of a proposed housing with care initiative (the Crichton Care Campus (CCC)). This sought the perspectives of a range of key stakeholders on the proposed model and how it might be best realised. The analyses of these findings show their relevance to debates on integrated housing with care, and reflect on the methodology used and its potential relevance to similar projects.

Design/methodology/approach
The study used a transactive planning approach, where grounded views are sought from a variety of stakeholders. A purposive sample identified informants from relevant health, social care and housing organisations and nine semi-structured interviews were conducted. These were transcribed and data analysis was undertaken on an “interactive” basis, relating care theory to empirical expressions.

Findings
The authors identify two contrasting orientations – inclusive “community-oriented” and professional “service-oriented”. This distinction provides the basis for a rudimentary conceptual map which can continue to be used in the planning process. Two significant variables within the conceptual map were the extent to which CCC should be intergenerational and as such, the degree to which care should come from formalised and self-care/informal sources. The potential to achieve an integrated approach was high with stakeholders across all sectors fully supporting the CCC concept and agreeing on the need for it to have a mixed tenure basis and include a range of non-care amenities.

Originality/value
This paper offers originality in two respects. Methodologically, it describes an attempt to undertake early stage care planning using a needs led transactive methodology. In more practical terms, it also offers an innovative environment for considering any approach to care planning that actively seeks integration – based on an acknowledgement of complexity, a variety of perspectives and possible conflicts. The authors propose that the concepts of “community-orientation” and “service-orientation” are used as a helpful basis for planning negotiations, making implicit divergences explicit and thus better delineated.
Empirical study on the evaluation model of public satisfaction with typhoon disaster information disclosure
Authors: Zhong Zufeng , Duan Yaoqing 
Published: May 2018

Purpose
The purpose of this paper is to study major influencing factors on public satisfaction with regard to information disclosure amid typhoon disasters. Internal latent variables, including disaster information quality, information disclosure channels and disaster perception levels, significantly affected the degree of public satisfaction, which was key factors in determining account consumer satisfaction.

Design/methodology/approach
By conducting the questionnaire survey in typhoon-prone areas, 326 copies of the questionnaire about public satisfaction towards government information disclosure about typhoon were collected. An exponential model of satisfaction about information disclosure amid typhoon disasters was constructed and analyzed through the selection of latent variables, the hypotheses of the structural relationship and the establishment of measurable variables.

Findings
Disaster information quality, disaster information disclosure channels and disaster perception levels were all positively correlated with the dimensions of information performance perception dimensions. Public expectations also made positive contributions to public satisfaction. These findings strongly support the hypothesis that public satisfaction affects the government image and public trust.

Originality/value
With the Leizhou Peninsula, China attacked by the typhoon disasters as an example, the SEM was adopted to simulate the routes and its feasibility and scientificity were validated. It is valuable to build and analyze an evaluation model based on a structural equation model underlying the public satisfaction towards information disclosure amid typhoon disasters.
Heat insulation characteristics of multi-layer nonwovens
Authors: G. Gnanauthayan , R.S. Rengasamy , Kothari Vijayakumar 
Published: May 2018

Purpose
This paper aims to deal with the thermal resistance of multilayer nonwovens. The effect of fibre denier, cross-sectional shape and positioning within the layers were analysed with respect to the thermal resistance. Moreover, effect of compression on thermal resistance of the multilayer nonwoven structure have also be studied.

Design/methodology/approach
The study involves multiple layering of thermal bonded nonwoven webs and the effect of fibre denier and positioning of different nonwovens from the hot plate. To avoid the increase in thermal resistance because of the air gaps between layers, the nonwovens were enclosed within an acrylic frame to compress them to a thickness of 12 mm. Compressional behaviour of the nonwovens were tested at a rate of 5 mm/min with peak compressive load of 50 N. Multilayer nonwoven assemblies were tested for thermal resistance with compressive pressure of 3.5 gf/cm2 and compared with that tested at zero pressure.

Findings
In the study, three-layered nonwoven structure, provided better thermal resistance than their single component counterparts. The structural characteristic of the multilayer nonwovens affected the conductive, convective and the radiative heat transfer. In a multi-layer nonwoven, the top most layer should have the finest fibre as possible. Second preference may be given to the middle and followed by bottom layers in terms of fibre fineness. However, fine solid fibres performed poorly in terms of compression and recovery resulting in poor thermal resistance under compressive load.

Originality/value
The experimental approach of controlling thickness while evaluating the thermal resistance will help in nullify the effect of air gaps between the layer interface, thus focussing on the effect of fibre denier and the positioning of nonwovens. This paper also discusses the unique properties of fine solid fibre and hollow fibres and their role in providing better thermal insulation for extreme cold weather applications.
CO2 storage in the high Arctic: efficient modelling of pre‐stack depth‐migrated seismic sections for survey planning
Authors: Lubrano Lavadera P. , Kühn D. , Dando B.D.E. , Lecomte I. , Senger K. , Drottning Å. 
Published: May 2018

ABSTRACTThe sequestration of CO2 in subsurface reservoirs constitutes an immediate counter‐measure to reduce anthropogenic emissions of CO2, now recognized by international scientific panels to be the single most critical factor driving the observed global climatic warming. To ensure and verify the safe geological containment of CO2 underground, monitoring of the CO2 site is critical. In the high Arctic, environmental considerations are paramount and human impact through, for instance, active seismic surveys, has to be minimized. Efficient seismic modelling is a powerful tool to test the detectability and imaging capability prior to acquisition and thus improve the characterization of CO2 storage sites, taking both geological setting and seismic acquisition set‐up into account. The unique method presented here avoids the costly generation of large synthetic data sets by employing point spread functions to directly generate pre‐stack depth‐migrated seismic images. We test both a local‐target approach using an analytical filter assuming an average velocity and a full‐field approach accounting for the spatial variability of point spread functions. We assume a hypothetical CO2 plume emplaced in a sloping aquifer inspired by the conditions found at the University of Svalbard CO2 lab close to Longyearbyen, Svalbard, Norway, constituting an unconventional reservoir–cap rock system. Using the local‐target approach, we find that even the low‐to‐moderate values of porosity (5%–18%) measured in the reservoir should be sufficient to induce significant change in seismic response when CO2 is injected. The sensitivity of the seismic response to changes in CO2 saturation, however, is limited once a relatively low saturation threshold of 5% is exceeded. Depending on the illumination angle provided by the seismic survey, the quality of the images of five hypothetical CO2 plumes of varying volume differs depending on the steepness of their flanks. When comparing the resolution of two orthogonal 2D surveys to a 3D survey, we discover that the images of the 2D surveys contain significant artefacts, the CO2‐brine contact is misplaced and an additional reflector is introduced due to the projection of the point spread function of the unresolvable plane onto the imaging plane. All of these could easily lead to a misinterpretation of the behaviour of the injected CO2. Our workflow allows for testing the influence of geological heterogeneities in the target aquifer (igneous intrusions, faults, pervasive fracture networks) by utilizing increasingly complex and more realistic geological models as input as more information on the subsurface becomes available.