bluuebunny/crossref_metadata_2025_split huggingface dataset:
Taming Tax Competition with a European Corporate Income Tax
Authors: Candau Fabien , Le Cacheux Jacques 
Published: October 2018

Cet article propose une revue de la littérature originale sur la concurrence fiscale et apporte de nouvelles preuves empiriques concernant l’intensité des interactions stratégiques entre gouvernements européens, la concurrence fiscale est ainsi trois fois plus forte pour les actifs financiers que pour d’autres capitaux moins mobiles. Nous présentons également plusieurs stratégies d’optimisation fiscale d’entreprises multinationales et documentons quelques études de cas d’évasion fiscale. Les montants optimisés par ces entreprises sont comparables aux contributions annuelles versées au budget de l’UE par des pays comme le Royaume-Uni, l’Irlande, les Pays-Bas ou le Luxembourg. Nous estimons que les pertes totales de recettes pour les gouvernements de l’UE dues à l’évasion fiscale s’élèvent à près de 100 milliards d’euros. Après cette description de l’échec du système fiscal actuel, cet article analyse les régimes alternatifs tels que l’assiette commune consolidée pour l’impôt sur les sociétés (ACCIS) et conclut avec la perspective d’un impôt des sociétés européen comme véritable ressource propre pour le budget de l’UE.
Élections en mots-clics : avancée ou menace pour la démocratie ?
Authors: Warin Thierry , d’Amours Liette 
Published: October 2018

En quoi les réseaux sociaux changent-ils la dynamique des campagnes électorales ? Comment les partis politiques peuvent-ils en tirer profit ? Les réseaux sociaux sont-ils une menace ou un avantage pour les politiciens ? Et qu’en est-il pour la démocratie ?
Quelques enjeux autour des territoires ruraux
Authors: Bouquet Brigitte , Dubéchot Patrick 
Published: October 2018

L’article tente d’éclairer un monde en transformation – le monde rural – et d’en délimiter les contours et les problématiques. L’action sanitaire et sociale qui est mise en place doit accompagner depuis plus de quarante ans une évolution profonde des territoires et des espaces de vie, qui voit la « campagne » se réduire au profit d’une périurbanisation. Ces modifications de l’espace, mais aussi des modes de vie, engendrent des problématiques nouvelles et spécifiques comme la mobilité. Comment les travailleurs sociaux s’emparent-ils de ces évolutions, et des enjeux qui les accompagnent ? Cet article introduit donc la problématique générale du présent numéro.
Effects of Antiangiogenic Drugs on Expression Patterns of Epigenetic Pathway Genes
Authors: Hamid Mohamed A. , Moustafa Mohamed Tarek , Càceres-del-Carpio Javier , Kuppermann Baruch D. , Kenney M. Cristina 
Published: October 2018

BACKGROUND AND OBJECTIVE:
To investigate the effects of antiangiogenic drugs on the transcription profile of acetylation genes in immortalized human retinal pigment epithelium cells (ARPE-19) in vitro.

MATERIALS AND METHODS:

This in vitro study evaluated the effect of antiangiogenic drugs on the expression of histone acetylation genes on immortalized ARPE-19 cell cultures. ARPE-19 cells were cultured, plated, and treated for 24 hours with aflibercept (Eylea; Regeneron, Tarrytown, NY), ranibizumab (Lucentis; Genentech, South San Francisco, CA), or bevacizumab (Avastin; Genentech, South San Francisco, CA) at one (1×) or two times (2×) the concentrations of the clinical intravitreal dose. Untreated cells were used as controls. RNA was isolated, and real-time quantitative reverse transcription polymerase chain reaction analysis was performed on individual samples to quantify expression levels of genes associated with epigenetic acetylation pathways: histone acetyltransferase 1 (
HAT1
) and histone deacetylases 1, 6, and 11 (
HDAC1
,
HDAC6
, and
HDAC11
). Differences in cycle thresholds (ΔΔCts) were obtained, and folds were calculated using the formula 2
^ΔΔCt
. Main outcome measures were expression levels of candidate genes in treated versus untreated samples.

RESULTS:

Compared with untreated cells, 1× ranibizumab-treated cells expressed higher levels of
HDAC6
, and 2× ranibizumab-treated cells expressed higher
HDAC11
levels. Bevacizumab-treated (1×) cells had significant change in
HDAC1
,
HDAC6
, and
HDAC11
. In cultures treated with 2× bevacizumab, only
HDAC11
expression levels were significantly affected compared with controls. Aflibercept-treated (1×) cells had changes in expression of
HDAC1
,
HDAC6
, and
HDAC11
. At 2× concentration, only
HDAC11
was significantly changed.

CONCLUSION:
Our results show that antiangiogenic drugs can affect the transcription profile of genes regulating the histone acetylation status in ARPE-19 cells in vitro. This finding may have an implication in differential patient response to anti-vascular endothelial growth factor therapy by means of possible interactions between treatment and patient's epigenomic profile.

[
Ophthalmic Surg Lasers Imaging Retina
. 2018;49:S29–S33.]
Une nouvelle tradition : la céramique algéroise à l’aube du xxe siècle
Authors: Álvarez Dopico Clara Ilham 
Published: October 2018

L’architecture néo-mauresque et la transformation des grandes demeures suburbaines d’époque ottomane à Alger, donne naissance, à la fin des années 1880, à une production de céramique historiciste, qui décline à partir des années 1920. Il est question ici du milieu algérien – collectionneurs, architectes, industriels, historien – qui, revendiquant la tradition, permet l’essor de cette nouvelle industrie d’art. L’article présente une expérience éphémère de rénovation, plutôt création, de l’artisanat algérois : l’atelier de céramique ouvert, entre 1899 et 1901, au musée des Arts et des Antiquités à Mustapha sous la direction du conservateur Georges Marye et de l’écrivain Émile Violard.
Tlemcen ou la source des sources
Authors: Sanson Hervé 
Published: October 2018

L’ouvrage Tlemcen ou les lieux de l’écriture de l’écrivain algérien d’expression française Mohammed Dib, publié en 1993, est une œuvre singulière : associant photographies prises par le jeune Dib au lendemain de la guerre aux photographies prises quasiment cinquante ans plus tard par le photographie français Philippe Bordas, l’opus est prétexte pour l’écrivain à une exploration par l’écriture d’une ville spécifique, Tlemcen, et des strates mémorielles qui la composent. Mais c’est aussi à une exploration de l’œuvre dibienne que cet ouvrage invite : faire le portrait de Tlemcen, entreprise par essence infinie, consiste à faire le portrait d’une écriture.
Effect of vitamin D supplementation on sustained virological response in genotype 1/4 chronic hepatitis C treatment-naïve patients from India
Authors: Behera Manas Kumar , Shukla Sunit Kumar , Dixit Vinod Kumar , Nath Preetam , Abhilash V. B. , Asati Pankaj Kumar , Jain Ashok Kumar 
Published: October 2018

Background & objectives:
The effect of vitamin D supplementation on response to antiviral therapy in hepatitis C virus (HCV) genotype 1 and 4 infection still remains unclear, with studies yielding inconsistent results. The aim of the present study was to assess the effect of vitamin D supplementation on treatment outcome in patients with genotype 1/4 chronic hepatitis C (CHC) infection.

Methods:
Sixty consecutive, treatment-naïve, genotype 1 and 4 chronic HCV patients were included in the study. The patients were randomized into two groups: Vitamin D supplemented group received pegylated (PEG)-interferon α-2a 180 μg per week plus ribavirin (RBV) (1000-1200 mg/d) together with vitamin D3 (2000 IU/d) and control group received identical therapy without vitamin D (32 patients).

Results:
There were no significant differences between the two groups in terms of age, sex, body mass index and baseline laboratory values. Lower vitamin D levels were associated with higher grades of fibrosis in liver histology (vitamin D >20 ng/ml - 70% vs vitamin D <20 ng/ml - 37%, P<0.05). Vitamin D supplemented group had similar rapid viral response (40 vs 28%, P=0.36), complete early viral response (53.2 vs 40%, P=0.34), end of treatment response (64 vs 46%, P=0.17) and sustained virological response (SVR) (60 vs 44%, P=0.19) as compared to control group. Interleukin 28B polymorphism [odds ratio (OR)-15.37, 95% confidence interval (CI)-2.32-101.76, P=0.04] and baseline serum vitamin D levels (OR-6.36, 95% CI-1.36-29.61 P=0.02) were independent predictors of SVR in genotype 1/4 CHC. Vitamin D supplementation was not found to be predictor of response in genotype 1/4 CHC on multivariate analysis (OR-2.79, 95% CI- 0.63-12.34, P=0.74).

Interpretation & conclusions:
The present study showed that addition of vitamin D to PEG/RBV combination therapy in treatment-naïve patients who were infected with HCV genotype 1/4 had no effect on the rates of rapid, early and sustained viral responses.
A surface antigen of Orientia tsutsugamushi activates human monocyte-derived dendritic cells via nuclear factor-kB & p38 mitogen-activated protein kinase pathways
Authors: Jan Rong-Hwa , Chen Chia-Jung , Hong Yi-Ren , Lin Yu-Li , Chen Li-Kuang 
Published: October 2018

Background & objectives:
Scrub typhus is a chigger-borne disease caused by Orientia tsutsugamushi. The immunological reactions to O. tsutsugamushi infection are not completely understood. In this study, we investigated the response of dendritic cells (DCs) to a major 56-kDa scrub typhus antigen Sta56.

Methods:
Monocyte-derived human DCs were incubated with different concentrations of recombinant Sta56 and analyzed for maturation based on phagocytic capacity, the ability to induce T-cell proliferation, expression of surface markers, cytokine secretion and activation of toll-like receptor (TLR)-dependent signalling pathways.

Results:
Treatment of DCs with Sta56 induced cell surface expression of CD80, CD83, CD86 and MHC Class II increased the production of interleukin-12 (IL-12) p40, IL-12 p70 and IL-10 and decreased DC phagocytic capacity. Furthermore, Sta56 increased the ability of DCs to activate T-cell proliferation and interferon-γ secretion. TLR4-specific antibodies neutralized Sta56-elicited effects on DC maturation, suggesting direct interaction between Sta56 and TLR4. Moreover, Sta56 activated nuclear factor (NF)-κB and p38 mitogen-activated protein kinase (MAPK) signalling as evidenced by decrease in Sta56-induced cytokine production and surface marker expression by specific inhibitors helenalin and SB203580, respectively, and increase in IκBα and p38 phosphorylation and NF-κB-DNA binding.

Interpretation & conclusions:
Our results showed that the surface antigen of O. tsutsugamushi activated DCs through interaction with TLR4 and activation of MAPK and NF-κB signalling, suggesting Sta56 as a potential candidate molecule for the development of vaccine against scrub typhus.
Contribution of insulin resistance to decreased baroreceptor sensitivity & cardiometabolic risks in pre-obesity & obesity
Authors: Indumathy Jagadeeswaran , Pal Gopal Krushna , Pal Pravati , Ananthanarayanan Palakkad Hariharan , Parija Subash Chandra , Balachander Jayaraman , Dutta Tarun Kumar 
Published: October 2018

Background & objectives:
Although insulin resistance (IR) is a known complication in obesity, the physiological mechanisms linking IR with cardiometabolic risks in obesity have not been well studied. This study was conducted to assess the difference in cardiovascular (CV) risk profile in IR and non-IR (NIR) conditions, and contribution of IR to cardiometabolic risks in pre-obese and obese individuals.

Methods:
Basal CV, blood pressure variability, autonomic function test and cardiometabolic parameters were recorded in pre-obese (n=86) and obese (n=77) individuals during 2012 and 2015. The association of altered cardiometabolic parameters with homeostatic model for IR (HOMA-IR) in pre-obese and obese groups and with baroreceptor sensitivity (BRS) in IR and NIR groups was calculated by appropriate statistical analysis.

Results:
Decreased BRS, a known CV risk and cardiometabolic parameters were significant in IR (pre-obese and obese) group compared to the NIR group. Sympathovagal imbalance in the form of increased sympathetic and decreased parasympathetic activities was observed in individuals with IR. There was no significant difference in the level of independent contribution of HOMA-IR to cardiometabolic parameters in pre-obese and obese groups. Adiponectin and inflammatory markers had an independent contribution to BRS in IR group.

Interpretation & conclusions:
Findings of the present study demonstrated that the intensity of cardiometabolic derangements and CV risk were comparable between IR, pre-obese and obese individuals. Pro-inflammatory state, dyslipidaemia and hypoadiponectinaemia might contribute to CV risk in these individuals with IR. IR could possibly be the link between altered metabolic profile and increased CV risks in these individuals independent of the adiposity status.
MODIS Collection 6 MAIAC algorithm
Authors: Lyapustin Alexei , Wang Yujie , Korkin Sergey , Huang Dong 
Published: October 2018

Abstract. This paper describes the latest version of the algorithm MAIAC
used for processing the MODIS Collection 6 data record. Since initial
publication in 2011–2012, MAIAC has changed considerably to adapt to global
processing and improve cloud/snow detection, aerosol retrievals and
atmospheric correction of MODIS data. The main changes include (1) transition
from a 25 to 1 km scale for retrieval of the spectral regression coefficient
(SRC) which helped to remove occasional blockiness at 25 km scale in the
aerosol optical depth (AOD) and in the surface reflectance, (2) continuous
improvements of cloud detection, (3) introduction of smoke and dust tests to
discriminate absorbing fine- and coarse-mode aerosols, (4) adding over-water
processing, (5) general optimization of the LUT-based radiative transfer for
the global processing, and others. MAIAC provides an interdisciplinary suite
of atmospheric and land products, including cloud mask (CM), column water
vapor (CWV), AOD at 0.47 and 0.55 µm, aerosol type (background,
smoke or dust) and fine-mode fraction over water; spectral bidirectional
reflectance factors (BRF), parameters of Ross-thick Li-sparse (RTLS)
bidirectional reflectance distribution function (BRDF) model and
instantaneous albedo. For snow-covered surfaces, we provide subpixel snow
fraction and snow grain size. All products come in standard HDF4 format at
1 km resolution, except for BRF, which is also provided at 500 m resolution
on a sinusoidal grid adopted by the MODIS Land team. All products are
provided on per-observation basis in daily files except for the BRDF/Albedo
product, which is reported every 8 days. Because MAIAC uses a time
series approach, BRDF/Albedo is naturally gap-filled over land where missing
values are filled-in with results from the previous retrieval. While the BRDF
model is reported for MODIS Land bands 1–7 and ocean band 8, BRF is reported
for both land and ocean bands 1–12. This paper focuses on MAIAC cloud
detection, aerosol retrievals and atmospheric correction and describes MCD19
data products and quality assurance (QA) flags.
Zonal-mean data set of global atmospheric reanalyses on pressure levels
Authors: Martineau Patrick , Wright Jonathon S. , Zhu Nuanliang , Fujiwara Masatomo 
Published: October 2018

Abstract. This data set, which is prepared for the Stratosphere–troposphere Processes And their Role in Climate (SPARC) Reanalysis
Intercomparison Project (S-RIP), provides several zonal-mean diagnostics
computed from reanalysis data on pressure levels. Diagnostics are currently
provided for a variety of reanalyses, including ERA-40, ERA-Interim, ERA-20C,
NCEP–NCAR, NCEP–DOE, CFSR, 20CR v2 and v2c, JRA-25, JRA-55, JRA-55C,
JRA-55AMIP, MERRA, and MERRA-2. The data set will be expanded to include
additional reanalyses as they become available. Basic dynamical variables
(such as temperature, geopotential height, and three-dimensional winds) are
provided in addition to a complete set of terms from the Eulerian-mean and
transformed-Eulerian-mean momentum equations. Total diabatic heating and its
long-wave and shortwave components are included as availability permits,
along with heating rates diagnosed from the basic dynamical variables using
the zonal-mean thermodynamic equation. Two versions of the data set are
provided, one that uses horizontal and vertical grids provided by the various
reanalysis centers and another that uses a common grid (CG) to facilitate
comparison among data sets. For the common grid, all diagnostics are
interpolated horizontally onto a regular 2.5∘×2.5∘ grid
for a subset of pressure levels that are common among all included
reanalyses. The dynamical
(Martineau, 2017, https://doi.org/10.5285/b241a7f536a244749662360bd7839312)
and diabatic
(Wright, 2017, https://doi.org/10.5285/70146c789eda4296a3c3ab6706931d56)
variables are archived and maintained by the Centre for Environmental Data
Analysis (CEDA).
Convection-permitting regional climate simulations for representing floods in small- and medium-sized catchments in the Eastern Alps
Authors: Reszler Christian , Switanek Matthew Blaise , Truhetz Heimo 
Published: October 2018

Abstract. Small-scale floods are a consequence of high precipitation rates in small
areas that can occur along frontal activity and convective storms. This
situation is expected to become more severe due to a warming climate, when
single precipitation events resulting from deep convection become more
intense (super Clausius–Clapeyron effect). Regional climate model (RCM)
evaluations and inter-comparisons have shown that there is evidence that an
increase in RCM resolution and, in particular, at the convection-permitting
scale will lead to a better representation of the spatial and temporal
characteristics of heavy precipitation at small and medium scales. In this
paper, the benefits of grid size reduction and bias correction in climate
models are evaluated in their ability to properly represent flood generation
in small- and medium-sized catchments. The climate models are sequentially
coupled with a distributed hydrological model. The study area is the Eastern
Alps, where small-scale storms often occur along with heterogeneous rainfall
distributions leading to a very local flash flood generation. The work is
carried out in a small multi-model framework using two different RCMs (CCLM
and WRF) in different grid sizes. Bias correction is performed by the use of
the novel scaled distribution mapping (SDM), which is similar to the usual quantile
mapping (QM) method. The results show that, in the investigated RCM ensemble, no
clear added value of the usage of convection-permitting RCMs for the purpose
of flood modelling can be found. This is based on the fact that flood events
are the consequence of an interplay between the total precipitation amount
per event and the temporal distribution of rainfall intensities on a
sub-daily scale. The RCM ensemble is lacking in one and/or the other. In
the small catchment (<100 km2), a favourable superposition of the
errors leads to seemingly good CCLM 3 km results both for flood statistics and
seasonal occurrence. This is, however, not systematic across the catchments.
The applied bias correction only corrects total event rainfall amounts in an
attempt to reduce systematic errors on a seasonal basis. It does not account
for errors in the temporal dynamics and deteriorates the results in the small
catchment. Therefore, it cannot be recommended for flood modelling.
Note stylistique sur le récit de voyage : les pages bayonnaises de Pyrénées (1843) de Victor Hugo
Authors: Labertit André 
Published: October 2018

Cette étude sur les pages bayonnaises extraites de Pyrénées (1843) s’inscrit dans une recherche sur la nature littéraire des récits de voyages et son expression stylistique. Écrites 32 ans après une étape à Bayonne sur le chemin qui conduisait Victor Hugo, enfant, auprès de son père à Madrid, elles sont considérées dans leur singularité organique. Le moi de Hugo, tout imprégné qu’il est de Bayonne, de l’Espagne, de Napoléon, envahit la relation référentielle ; le temps remémoré ne l’est pas en vue de retrouver le passé mais de l’évoquer dans une rêverie moins divagante qu’orientée. Évocation proprement créatrice, rendue patente par l’écart entre le descriptible et le décrit.
La mise en fiction d’un voyage insulaire chez Ignacio Aldecoa et Emmanuel Hocquard
Authors: Oliver Frade José M. 
Published: October 2018

Les espaces insulaires représentent un sujet récurrent dans la littérature universelle ​dès lorsqu'ils permettent la coexistence d'une perspective réelle et d'une interprétation allégorique et qu’ils servent de support à un discours dans lequel se confondent le vrai et l'imaginaire. Dans cet article, nous allons mettre en lumière les parallélismes et les divergences qui se produisent dans le traitement symbolico-spatial que deux écrivains contemporains, qui appartiennent à deux domaines linguistiques différents, réservent à un même contexte insulaire. Nous comparerons ainsi les romans ​ Parte de una historia (1967) de Ignacio Aldecoa et Aerea dans les fôrets de Manhattan (1985) de Emmanuel Hocquard, qui se déroulent sur la petite île canarienne de La Graciosa, transformée en la destination d'un voyage existentiel par les deux auteurs.
Zarathoustra aux îles : Vasco (Chadourne, 1927) et Touriste de bananes (Simenon, 1938)
Authors: Lojacono Florence 
Published: October 2018

En cette période de l’entre-deux-guerres, Marc Chadourne et Georges Simenon ont de nombreux intérêts communs : voyages, lectures et, bien sûr, le grand reportage littéraire. Dans cet article nous irons à Tahiti, où ont séjourné les deux auteurs, grâce à Vasco de Chadourne et à Touriste de bananes de Simenon. Dans les deux romans il s’agit de suivre le parcours d’un protagoniste qui, fuyant la France, aborde les rivages d’une Polynésie qu’il pense être le cadre propice de sa renaissance. Nous verrons de quelle manière, dans ces deux textes, surgit le désir de l’île comme remède au spleen d’une part et comme antidote au nihilisme d’autre part. Même si l’exotisme est au rendez-vous, la lumière étincelante d’une nature intacte se révèle incapable de chasser les vieilles lâchetés, les plages immaculées ne peuvent endiguer les vagues d’angoisse qui les submergent de plus en plus souvent. Jusqu’à l’épuisement. Jusqu’à suicide.In the interwar period, Marc Chadourne and Georges Simenon had many common interests: travel, readings and of course, literary reportage. In this paper we will travel to Tahiti, where both authors lived, through the works Vasco by Chadourne and Touriste de bananes by Simenon. Each novel follows the path of a man who, escaping from France, reaches the shores of a Polynesia he thinks will be the fertile ground for his rebirth. We will see how, in both novels, the desire for the island arises, on the one hand as a drug against the spleen, and on the other as an antidote to nihilism. In spite of the island’s exoticism, the sparkling light over an unspoilt nature is unable to chase away the cowardice from their lives; the immaculate beaches are powerless to stem the waves of anxiety and the protagonists are increasingly overwhelmed by angst. Until exhaustion. Until suicide.
D’une actualité dans le roman maghrébin
Authors: Amraoui Abdelaziz 
Published: October 2018

Le 11 septembre 2001 est une date charnière, non seulement par rapport à des considérations géopolitiques et géostratégiques, en relation avec le terrorisme international, mais aussi en relation avec son impact sur le monde artistique et littéraire. Le Maghreb n’est pas en reste. Salim Bachi, l’Algérien, et Mahi Binebine, le Marocain, vont ouvrir l’espace de tous les dangers, sans sécurité de notre post-modernité très agitée, post-modernité qui replonge le monde dans une deuxième« ère de soupçon » avec son lot d’interrogations et de doutes. Ils vont percer, et ce ontologiquement, ce mystère de la construction de l’orthodoxie aveugle et aveuglante, chez des personnages totalement décalés du monde dans lequel ils vivent, et dont l’éducation et les origines sont foncièrement différentes. Au nom d’une lecture de l’Islam au diapason de la réalité, des vengeurs de la cause musulmane vont semer la terreur, d’un côté aux États Unis, puis, dans une terre de l’Islam, le Maroc, contre des musulmans et des non-musulmans !