bluuebunny/crossref_metadata_2025_split huggingface dataset:
Travel vaccination recommendations and infection risk in HIV-positive travellers
Authors: Chang Lisa , Lim Bryan Chang Wei , Flaherty Gerard T , Torresi Joseph 
Published: May 2019

Abstract

Background
With the advent of highly active antiretroviral drugs for the treatment of human immunodeficiency virus (HIV) it has become possible for people with HIV to travel to destinations that may place them at risk of a number of infectious diseases. Prevention of infections by vaccination is therefore of paramount importance for these travellers. However, vaccine responsiveness in HIV-positive individuals is not infrequently reduced compared to HIV-negative individuals. An understanding of the expected immune responses to vaccines in HIV-positive travellers is therefore important in planning the best approach to a pretravel consultation.

Methods
A PubMed search was performed on HIV or acquired immune deficiency syndrome together with a search for specific vaccines. Review of the literature was performed to develop recommendations on vaccinations for HIV-positive travellers to high-risk destinations.

Results
The immune responses to several vaccines are reduced in HIV-positive people. In the case of vaccines for hepatitis A, hepatitis B, influenza, pneumococcus, meningococcus and yellow fever there is a good body of data in the literature showing reduced immune responsiveness and also to help guide appropriate vaccination strategies. For other vaccines like Japanese encephalitis, rabies, typhoid fever, polio and cholera the data are not as robust; however, it is still possible to gain some understanding of the reduced responses seen with these vaccines.

Conclusion
This review provides a summary of the immunological responses to commonly used vaccines for the HIV-positive travellers. This information will help guide travel medicine practitioners in making decisions about vaccination and boosting of travellers with HIV.
UNIT project: Universe N-body simulations for the Investigation of Theoretical models from galaxy surveys
Authors: Chuang Chia-Hsun , Yepes Gustavo , Kitaura Francisco-Shu , Pellejero-Ibanez Marcos , Rodríguez-Torres Sergio , Feng Yu , Metcalf Robert Benton , Wechsler Risa H , Zhao Cheng , To Chun-Hao , Alam Shadab , Banerjee Arka , DeRose Joseph , Giocoli Carlo , Knebe Alexander , Reyes Guillermo 
Published: May 2019

Abstract
We present the UNIT N-body cosmological simulations project, designed to provide precise predictions for non-linear statistics of the galaxy distribution. We focus on characterizing statistics relevant to emission line and luminous red galaxies in the current and upcoming generation of galaxy surveys. We use a suite of precise particle mesh simulations (fastpm) as well as with full N-body calculations with a mass resolution of ${\sim } 1.2\times 10^9\, h^{-1}$M⊙ to investigate the recently suggested technique of Angulo and Pontzen to suppress the variance of cosmological simulations. We study redshift-space distortions, cosmic voids, higher order statistics from z = 2 down to 0. We find that both two- and three-point statistics are unbiased. Over the scales of interest for baryon acoustic oscillations and redshift-space distortions, we find that the variance is greatly reduced in the two-point statistics and in the cross-correlation between haloes and cosmic voids, but is not reduced significantly for the three-point statistics. We demonstrate that the accuracy of the two-point correlation function for a galaxy survey with effective volume of 20 (h−1Gpc)3 is improved by about a factor of 40, indicating that two pairs of simulations with a volume of 1 (h−1Gpc)3 lead to the equivalent variance of ∼150 such simulations. The N-body simulations presented here thus provide an effective survey volume of about seven times the effective survey volume of Dark Energy Spectroscopic Instrument or Euclid. The data from this project, including dark matter fields, halo catalogues, and their clustering statistics, are publicly available.
Simulations of radiative turbulent mixing layers
Authors: Ji (季索清) Suoqing , Oh S Peng , Masterson Phillip 
Published: May 2019

ABSTRACTRadiative turbulent mixing layers should be ubiquitous in multi-phase gas with shear flow. They are a potentially attractive explanation for the high ions such as O vi seen in high-velocity clouds and the circumgalactic medium (CGM) of galaxies. We perform 3D magnetohydrohynamics (MHD) simulations with non-equilibrium (NEI) and photoionization modelling, with an eye towards testing simple analytic models. Even purely hydrodynamic collisional ionization equilibrium (CIE) calculations have column densities much lower than observations. Characteristic inflow and turbulent velocities are much less than the shear velocity, and the layer width $h \propto t_{\mathrm{cool}}^{1/2}$ rather than h ∝ tcool. Column densities are not independent of density or metallicity as analytic scalings predict, and show surprisingly weak dependence on shear velocity and density contrast. Radiative cooling, rather than Kelvin–Helmholtz instability, appears paramount in determining the saturated state. Low pressure due to fast cooling both seeds turbulence and sets the entrainment rate of hot gas, whose enthalpy flux, along with turbulent dissipation, energizes the layer. Regardless of initial geometry, magnetic fields are amplified and stabilize the mixing layer via magnetic tension, producing almost laminar flow and depressing column densities. NEI effects can boost column densities by factors of a few. Suppression of cooling by NEI or photoionization can, in principle, also increase O vi column densities, but, in practice, is unimportant for CGM conditions. To explain observations, sightlines must pierce hundreds or thousands of mixing layers, which may be plausible if the CGM exists as a ‘fog’ of tiny cloudlets.
Molecular environs and triggered star formation around the large Galactic infrared bubble N 24
Authors: Li Xu , Esimbek Jarken , Zhou Jianjun , Baan W A , Ji Weiguang , Tang Xindi , Wu Gang , Tang Xiaoke , Li Qiang , Ma Yingxiu , Sailanbek Serikbek , Li Dalei , Alimbetova Dina 
Published: May 2019

Abstract
A multi-wavelength analysis of the large Galactic infrared bubble N 24 is presented in this paper in order to investigate the molecular and star-formation environment around expanding H ii regions. Using archival data from Herschel and ATLASGAL, the distribution and physical properties of the dust over the entire bubble are studied. Using the Clumpfind2d algorithm, 23 dense clumps are identified, with sizes and masses in the range 0.65–1.73 pc and 600–16 300 M⊙, respectively. To analyse the molecular environment in N 24, observations of NH3 (1,1) and (2,2) were carried out using the Nanshan 26-m radio telescope. Analysis of the kinetic temperature and gravitational stability of these clumps suggests gravitational collapse in several of them. The mass–size distributions of the clumps and the presence of massive young protostars indicate that the shell of N 24 is a region of ongoing massive-star formation. The compatibility of the dynamical and fragmentation timescales and the overabundance of young stellar objects and clumps on the rim suggest that the ‘collect-and-collapse’ mechanism is in play at the boundary of the bubble, but the existence of the infrared dark cloud at the edge of bubble indicates that a ‘radiation-driven implosion’ mechanism may also have played a role there.
Pergola-web: a web server for the visualization and analysis of longitudinal behavioral data using repurposed genomics tools and standards
Authors: Espinosa-Carrasco Jose , Pulido Toni Hermoso , Erb Ionas , Dierssen Mara , Ponomarenko Julia , Notredame Cedric 
Published: May 2019

Abstract
We present a new web application to query and visualize time-series behavioral data: the Pergola web-server. This server provides a user-friendly interface for exploring longitudinal behavioral data taking advantage of the Pergola Python library. Using the server, users can process the data applying some basic operations, such as binning or grouping, while formatting the data into existing genomic formats. Thanks to this repurposing of genomics standards, the application automatically renders an interactive data visualization based on sophisticated genome visualization tools. Our tool allows behavioral scientists to share, display and navigate complex behavioral data comprising multiple individuals and multiple data types, in a scalable and flexible manner. A download option allows for further analysis using genomic tools. The server can be a great resource for the field in a time where behavioral science is entering a data-intensive cycle thanks to high-throughput behavioral phenotyping platforms. Pergola is publicly available at http://pergola.crg.eu/.
SuhB is an integral part of the ribosomal antitermination complex and interacts with NusA
Authors: Dudenhoeffer Benjamin R , Schneider Hans , Schweimer Kristian , Knauer Stefan H 
Published: May 2019

AbstractThe synthesis of ribosomal RNA (rRNA) is a tightly regulated central process in all cells. In bacteria efficient expression of all seven rRNA operons relies on the suppression of termination signals (antitermination) and the proper maturation of the synthesized rRNA. These processes depend on N-utilization substance (Nus) factors A, B, E and G, as well as ribosomal protein S4 and inositol monophosphatase SuhB, but their structural basis is only poorly understood. Combining nuclear magnetic resonance spectroscopy and biochemical approaches we show that Escherichia coli SuhB can be integrated into a Nus factor-, and optionally S4-, containing antitermination complex halted at a ribosomal antitermination signal. We further demonstrate that SuhB specifically binds to the acidic repeat 2 (AR2) domain of the multi-domain protein NusA, an interaction that may be involved in antitermination or posttranscriptional processes. Moreover, we show that SuhB interacts with RNA and weakly associates with RNA polymerase (RNAP). We finally present evidence that SuhB, the C-terminal domain of the RNAP α-subunit, and the N-terminal domain of NusG share binding sites on NusA-AR2 and that all three can release autoinhibition of NusA, indicating that NusA-AR2 serves as versatile recruitment platform for various factors in transcription regulation.
New-onset glucose disorders in peritoneal dialysis patients: a meta-analysis and systematic review
Authors: Xue Cheng , Gu Yan-Yan , Cui Cheng-Ji , Zhou Chen-Chen , Wang Xian-Dong , Ruan Meng-Na , Huang Lin-Xi , Chen Si-Xiu , Yang Bo , Chen Xu-Jiao , Qian Yi-Xin , Wu Jun , Zhao Xue-Zhi , Zhang Yu-Qiang , Mei Chang-Lin , Zhang Shou-Lin , Xu Jing , Mao Zhi-Guo 
Published: May 2019

Abstract

Background
Peritoneal dialysis (PD) patients are at high risk of developing glucose metabolism disturbance (GMD). The incidence and prevalence of new-onset GMD, including diabetes mellitus (DM), impaired glucose tolerance (IGT) and impaired fast glucose (IFG), after initiation of PD, as well as their correlated influence factors, varies among studies in different areas and of different sample sizes. Also, the difference compared with hemodialysis (HD) remained unclear. Thus we designed this meta-analysis and systematic review to provide a full landscape of the occurrence of glucose disorders in PD patients.

Methods
We searched the MEDLINE, Embase, Web of Science and Cochrane Library databases for relevant studies through September 2018. Meta-analysis was performed on outcomes using random effects models with subgroup analysis and sensitivity analysis.

Results
We identified 1124 records and included 9 studies involving 13 879 PD patients. The pooled incidence of new-onset DM (NODM) was 8% [95% confidence interval (CI) 4–12; I2 = 98%] adjusted by sample sizes in PD patients. Pooled incidence rates of new-onset IGT and IFG were 15% (95% CI 3–31; I2 = 97%) and 32% (95% CI 27–37), respectively. There was no significant difference in NODM risk between PD and HD [risk ratio 0.99 (95% CI 0.69–1.40); P = 0.94; I2 = 92%]. PD patients with NODM were associated with an increased risk of mortality [hazard ratio 1.06 (95% CI 1.01–1.44); P &lt; 0.001; I2 = 92.5%] compared with non-DM PD patients.

Conclusions
Around half of PD patients may develop a glucose disorder, which can affect the prognosis by significantly increasing mortality. The incidence did not differ among different ethnicities or between PD and HD. The risk factor analysis did not draw a definitive conclusion. The glucose tolerance test should be routinely performed in PD patients.
Radiotherapy, Lymphopenia, and Host Immune Capacity in Glioblastoma: A Potentially Actionable Toxicity Associated With Reduced Efficacy of Radiotherapy
Authors: Kleinberg Lawrence , Sloan Lindsey , Grossman Stuart , Lim Michael 
Published: May 2019

Abstract
Radiotherapy is cytotoxic to tumor cells and is therefore a critical component of therapy for many malignancies, including glioblastoma (GBM). We now appreciate the value of the immunomodulatory effects of radiation that may be important to overall therapeutic success in some patients with this primary brain tumor. Although potentially beneficial immune-stimulating properties of radiotherapy treatment have been the focus of recent study, this modality is actually at the same time associated with the depletion of lymphocytes, which are crucial to the defense against neoplastic development and progression. In this review, we describe the association of systemic lymphopenia with poor tumor outcome, present evidence that radiotherapy is an important contributing cause of lymphodepletion, describe the systemic immune context of tumor and brain injury that contributes to immunosuppression, describe other contributing factors to lymphopenia including concomitant medications and treatments, and speculate about the role of the normal physiologic response to brain injury in the immunosuppressive dynamics of GBM. Radiotherapy is one significant and potentially actionable iatrogenic suppressor of immune response that may be limiting the success of therapy in GBM and other tumor types. Altered strategies for radiotherapy more permissive of a vigorous antineoplastic immune response may improve outcome for malignancy.
Residual Tumor Volume and Location Predict Progression After Primary Subtotal Resection of Sporadic Vestibular Schwannomas: A Retrospective Volumetric Study
Authors: Breshears Jonathan D , Morshed Ramin A , Molinaro Annette M , McDermott Michael W , Cheung Steven W , Theodosopoulos Philip V 
Published: May 2019

Abstract

BACKGROUND
Preservation of functional integrity during vestibular schwannoma surgery has become critical in the era of patient-centric medical decision-making. Subtotal tumor removal is often necessary when dense adhesions between the tumor and critical structures are present. However, it is unclear what the rate of tumor control is after subtotal resection (STR) and what factors are associated with recurrence.

OBJECTIVE
To determine the rate of residual tumor growth after STR and identify clinical and radiographic predictors of tumor progression.

METHODS
A single-institution retrospective study was performed on all sporadic vestibular schwannomas that underwent surgical resection between January 1, 2002 and December 31, 2015. Clinical charts, pathology, radiology, and operative reports were reviewed. Volumetric analysis was performed on all pre- and postoperative MR imaging. Univariate and multivariate logistic regression was performed to identify predictors of the primary endpoint of tumor progression. Kaplan–Meier analysis was performed to compare progression free survival between 2 groups of residual tumor volumes and location.

RESULTS
In this cohort of 66 patients who underwent primary STR, 30% had documented progression within a median follow up period of 3.1 yr. Greater residual tumor volume (OR 2.0 [1.1-4.0]) and residual disease within the internal auditory canal (OR 3.7 [1.0-13.4]) predicted progression on multivariate analysis.

CONCLUSION
These longitudinal data provide insight into the behavior of residual tumor, helping clinicians to determine if and when STR is an acceptable surgical strategy and to anchor expectations during shared medical decision-making consultation with patients.
High-temperature superconductivity in sulfur hydride evidenced by alternating-current magnetic susceptibility
Authors: Huang Xiaoli , Wang Xin , Duan Defang , Sundqvist Bertil , Li Xin , Huang Yanping , Yu Hongyu , Li Fangfei , Zhou Qiang , Liu Bingbing , Cui Tian 
Published: May 2019

ABSTRACT
The search for high-temperature superconductivity is one of the research frontiers in physics. In the sulfur hydride system, an extremely high Tc (∼200 K) has been recently developed at pressure. However, the Meissner effect measurement above megabar pressures is still a great challenge. Here, we report the superconductivity identification of sulfur hydride at pressure, employing an in situ alternating-current magnetic susceptibility technique. We determine the superconducting phase diagram, finding that superconductivity suddenly appears at 117 GPa and Tc reaches 183 K at 149 GPa before decreasing monotonically with increasing pressure. By means of theoretical calculations, we elucidate the variation of Tc in the low-pressure region in terms of the changing stoichiometry of sulfur hydride and the further decrease in Tc owing to a drop in the electron–phonon interaction parameter λ. This work provides a new insight into clarifying superconducting phenomena and anchoring the superconducting phase diagram in the hydrides.
Use of consensus methods to determine the early clinical signs of cerebral palsy
Authors: Boychuck Zachary , Andersen John , Bussières André , Fehlings Darcy , Kirton Adam , Li Patricia , Oskoui Maryam , Rodriguez Charo , Shevell Michael , Snider Laurie , Majnemer Annette ,   PROMPT Group
Published: May 2019

AbstractObjectivesTo develop expert-informed content regarding the early motor attributes of cerebral palsy (CP) that should prompt physician referral for diagnostic assessment of CP, as well as concurrent referral recommendations. This content will be used in the creation of knowledge translation (KT) tools for primary care practitioners and parents.MethodsTwo nominal group processes were conducted with relevant stakeholders, representing Canadian ‘content experts’ and ‘knowledge-users’, using an integrated KT approach.ResultsSix attributes were identified that should prompt referral for diagnosis. If the child demonstrates: Early handedness &lt;12 months; stiffness or tightness in the legs between 6 and 12 months; persistent fisting of the hands &gt;4 months; persistent head-lag &gt;4 months; inability to sit without support &gt;9 months; any asymmetry in posture or movement. Five referral recommendations were agreed upon: Motor intervention specialist (physical therapy and/or occupational therapy) for ALL; speech-language pathology IF there is a communication delay; audiology IF there is parental or healthcare professional concern regarding a communication delay; functional vision specialist (e.g., optometrist or occupational therapist) IF there is a vision concern (e.g., not fixating, following, or tracking); feeding specialist (e.g., occupational therapist, speech-language pathologist) IF there are feeding difficulties (e.g., poor sucking, poor swallowing, choking, and/or not gaining weight).ConclusionRigorous consensus methods provided the initial evidence necessary to inform the content of tools to assist primary care providers in the early detection of CP. Results will be validated through a Delphi process with international experts, and user-friendly formats of this KT tool will be developed collaboratively with stakeholders.
Bacterial communities associated with individual transparent exopolymer particles (TEP)
Authors: Zäncker Birthe , Engel Anja , Cunliffe Michael 
Published: May 2019

Abstract
Transparent exopolymer particles (TEP) are polysaccharide-rich microgels that are prevalent in the marine environment and have important roles in the aggregation of organic matter and carbon export from the euphotic zone. TEP are readily colonized by bacteria and utilized by specialized taxa, such as Alteromonadaceae. However, bacterial community composition specifically attached to natural TEP remains largely unknown. In this study, we isolated individual TEP from Plymouth Sound (UK) and performed DNA sequencing of the TEP-attached bacterial communities. We also sampled the cognate bulk seawater total bacterial communities for comparison. The bacterial communities associated with individual TEP showed distinct differences compared to the total bulk bacterioplankton communities, with Alteromonadaceae significantly more abundant on TEP. The TEP-associated Alteromonadaceae consisted of two operational taxonomic units that were closely related to Marinobacter and Glaciecola, both previously associated with biogenic aggregates and microgel-rich habitats. This study provides novel insight into marine bacterial–microgel interactions.
ROLE OF METEOROLOGY AND LITHOLOGY IN THE TEMPORAL VARIATION OF THE OUTDOOR RADON LEVEL
Authors: Kikaj D , Kovács T , Vaupotič J 
Published: May 2019

Abstract
The outdoor radon concentration was monitored together with the meteorological parameters at two contrasting complex topographies: sub-Alpine basin (SA) and sub-Mediterranean valley (SM) in winter (December 2017–February 2018) and summer (June–August 2018). The time series for each site and each season are evaluated in three different ways: (i) clear-sky and cloudy condition together, (ii) clear-sky conditions only (cloud cover <20%) and (iii) cloudy condition only (cloud cover >20%), and compared to the expected atmospheric boundary layer (ABL) ‘mixing volume’ caused by meteorological changes. The results have confirmed the sensitivity of diurnal and seasonal radon concentration to the expected ABL ‘mixing volume’ at the two selected sites. The relationship is more pronounced in calm clear-sky conditions. Cloudy conditions are associated with fast weather changes, when the ABL is well mixed and hourly mean radon concentrations do not follow the typical diurnal trend.
A REVIEW ON 210Po AND 210Pb IN INDIAN SEAFOOD AND DOSE TO CONSUMERS
Authors: Pillai G Sankaran , Chandrasekaran S , Baskaran R , Venkatraman B , Deepu R 
Published: May 2019

AbstractIndia is the second largest seafood producer in the world marketing more than 7000 edible species. In this regard, commendable studies have been conducted since the 1970s by different research groups and more data are reported. In this work, all the studies on 210Po and 210Pb measurements in abiotic and biotic components of India have been combined and reviewed. The concentrations of 210Po and 210Pb are estimated by radiochemical separation followed by alpha counting. Grain size, season, Tsunami waves and place of sampling have a decisive bearing on 210Po and 210Pb concentration in abiotic components. Plankton shows a higher Kd factor (104) compared to seaweeds and sea grass (103). Pond ecosystems recorded the highest Kd factor (4·3 × 104) compared to other freshwater and marine ecosystems. Bioaccumulation of 210Po and 210Pb varies with respect to variety of seafood. The committed effective dose (CED) calculated for shellfish species maintained a higher range of 2.5 × 10−2 mSv/y to 9.8 × 10−1 mSv/y and for fish species fluctuated from 3.8 × 10−4 mSv/y to 2.0 × 10−1 mSv/y. The studies conducted so far are scattered, and need to be gathered for future reference and planning (i.e. There is not much information available for Kerala, Karnataka, Maharashtra, Gujarat, Andhra, West Bengal and Odessa coast). Therefore, it is strongly recommended that further and more complete research is undertaken to study the bioaccumulation of 210Po and 210Pb from seafood. Overall, the present review concludes that Indian seafood is radiologically safe.