bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of Leptin on the Skeleton
Authors: Reid Ian R , Baldock Paul A , Cornish Jillian 
Published: August 2018

Abstract
Leptin originates in adipocytes, including those in bone marrow, and circulates in concentrations 20 to 90 times higher than those in the cerebrospinal fluid. It has direct anabolic effects on osteoblasts and chondrocytes, but it also influences bone indirectly, via the hypothalamus and sympathetic nervous system, via changes in body weight, and via effects on the production of other hormones (e.g., pituitary). Leptin’s role in bone physiology is determined by the balance of these conflicting effects. Reflecting this inconsistency, the leptin-deficient mouse has reduced length and bone mineral content of long bones but increased vertebral trabecular bone. A consistent bone phenotype in human leptin deficiency has not been established. Systemic leptin administration in animals and humans usually exerts a positive effect on bone mass, and leptin administration into the cerebral ventricles usually normalizes the bone phenotype in leptin-deficient mice. Reflecting the role of the sympathetic nervous system in mediating the central catabolic effects of leptin on the skeleton, β-adrenergic agonists and antagonists have major effects on bone in mice, but this is not consistently seen in humans. The balance of the central and peripheral effects of leptin on bone remains an area of substantial controversy and might vary between species and according to other factors such as body weight, baseline circulating leptin levels, and the presence of specific pathologies. In humans, leptin is likely to contribute to the positive relationship observed between adiposity and bone density, which allows the skeleton to respond appropriately to changes in soft tissue mass.
Idebenone and coenzyme Q10 are novel PPARα/γ ligands, with potential for treatment of fatty liver diseases
Authors: Tiefenbach Jens , Magomedova Lilia , Liu Jiabao , Reunov Arkadiy A. , Tsai Ricky , Eappen Neena S. , Jockusch Rebecca A. , Nislow Corey , Cummins Carolyn L. , Krause Henry M. 
Published: August 2018

ABSTRACT
Current peroxisome proliferator-activated receptor (PPAR)-targeted drugs, such as the PPARγ-directed diabetes drug rosiglitazone, are associated with undesirable side effects due to robust agonist activity in non-target tissues. To find new PPAR ligands with fewer toxic effects, we generated transgenic zebrafish that can be screened in high throughput for new tissue-selective PPAR partial agonists. A structural analog of coenzyme Q10 (idebenone) that elicits spatially restricted partial agonist activity for both PPARα and PPARγ was identified. Coenzyme Q10 was also found to bind and activate both PPARs in a similar fashion, suggesting an endogenous role in relaying the states of mitochondria, peroxisomes and cellular redox to the two receptors. Testing idebenone in a mouse model of type 2 diabetes revealed the ability to reverse fatty liver development. These findings indicate new mechanisms of action for both PPARα and PPARγ, and new potential treatment options for nonalcoholic fatty liver disease (NAFLD) and steatosis.
This article has an associated First Person interview with the first author of the paper.
Synthesis and Characterization of a New Series of Binuclear Pd(II) Biscatecholato Complexes: Non-Innocent Ligand-Based Approach to a Wide Range of Variation in Near-Infrared Absorptions of Mixed-Valence Complexes
Authors: Tahara Keishiro , Kadowaki Tomoya , Kikuchi Jun-ichi , Ozawa Yoshiki , Yoshimoto Soichiro , Abe Masaaki 
Published: August 2018

Abstract
In this study, we report synthesis of a new series of mixed-valence (MV) complexes having intervalence charge transfer (IVCT) energies variable from the first to the third telecommunication window. This wide-range modulation was achieved by variation of covalently-dimerized catecholato ligands, in combination with Pd(II) ions, which lowered the oxidation potentials and enabled access to MV states. Importantly, we found that regulation of the conjugation lengths enabled energy gap control and annulation of an additional benzene ring switched the nature of the IVCT transitions. These changes were accompanied by a cross-over from moderately delocalized Class II to delocalized Class III character according to the Robin-Day classification. Through accurate comparisons with well-known ferrocene counterparts and their hetero-conjugate, our non-innocent ligand-based approach is found to be effective for controlling IVCT parameters. These findings offer a new approach to materials design for electro-optic switching.
Carbapenems as water soluble organocatalysts
Authors: Williams Thomas L. , Nödling Alexander R. , Tsai Yu-Hsuan , Luk Louis Y. P. 
Published: August 2018

Background: Identification of organocatalysts functioning in aqueous environments will provide methods for more sustainable chemical transformations and allow tandem reactions with biocatalysts, like enzymes. Here we examine three water-soluble carbapenem antibiotics (meropenem, doripenem, and ertapenem) as secondary amine organocatalysts in aqueous environments. Methods: The Michael addition of nitromethane to cinnamaldehyde was used as the model reaction. The reactions were monitored by 1H NMR, and the enantioselectivity was determined by chiral HPLC. Results: The effects of buffer components, pH, organic co-solvents and anchoring into a protein scaffold were investigated. Moderate yields of the Michael addition were obtained in buffer alone. The use of methanol as a co-solvent in a ratio of 1:1 increases the yield by 50%. Anchoring of the catalysts into a protein backbone reverses the enatioselectivity of the reaction. Conclusions: Despite only moderate yields and enantioselectivities being obtained, this study lays the foundations for future development of efficient organocatalysis in aqueous environments.
Repeat two-stage exchange arthroplasty for prosthetic hip re-infection
Authors: Brown T. S. , Fehring K. A. , Ollivier M. , Mabry T. M. , Hanssen A. D. , Abdel M. P. 
Published: August 2018

Aims Recurrent infection following two-stage revision total hip arthroplasty (THA) for prosthetic joint infection (PJI) is a devastating complication. The purpose of this study was to report the survival of repeat two-stage revision hip arthroplasty, describe complications, and identify risk factors for failure. Patients and Methods We retrospectively identified 19 hips (19 patients) that had undergone repeat two-stage revision THA for infection between 2000 to 2013. There were seven female patients (37%) and the mean age was 60 years (30 to 85). Survival free from revision was assessed via Kaplan–Meier analysis. The patients were classified according to the Musculoskeletal Infection Society (MSIS) system, and risk factors for failure were identified. Mean follow-up was four years (2 to 11). Results Gram-positive bacteria were responsible for 16/17 (94%) of the re-infections where microbes were identified. Following the repeat two-stage exchange arthroplasty, survival free from any revision was 74% (95% confidence interval (CI) 56% to 96%, 14 at risk) at two years and 45% (95% CI 25% to 75%, five at risk) at five years. Failure to control infection resulted in re-operation or revision in 42%A of patients (8/19). Survival free from revision was not dependent on host grade. Conclusion Re-infection after two-stage exchange hip arthroplasty for PJI presents a challenging scenario. Repeat two-stage exchange arthroplasty has a low survival free from revision at five years (45%) and a high rate of re-infection (42%). Cite this article: Bone Joint J 2018;100-B:1157–61.
CONSTITUTIONAL HERMENEUTIC: A FAITH IN CONSTITUTION INTERPRETATION
Authors: Hermawan M. Ilham 
Published: August 2018

Hermeneutics can be used as a foundation of understanding on the interpretation of the constitution. Hermeneutic goal is not to develop a set of rules or procedures (methods) on textual interpretation, but as meta in the interpretation. Problems of constitutional interpretation cannot be blasted between theories that exist in the interpretation of the constitution. Clash between theories will not be able to resolve the constitutional issue. Each theory has a foundation of rationality and justification of each method. Therefore, the settlement should be drawn more into the realm of deep again, i.e. into the realm of ontology. The purpose is not to develop a set of rules or procedures on the interpretation of the text “method (be cognitive)” but the search for answers to no interpretation itself “ontis”. So objectivity lies in philosophy, then identified “not on what we do or we should do (in interpretation), but what happens to us other than what we want and do”. So it is clear that the hermeneutic assemble themselves on things that are ontological, and identify relationships that cannot be changed between the reader with the text, in the past and the present, which appears at the beginning of understanding. Keywords : constitutional, hermeneutic, constitution interpretation
JUVENILE JUSTICE SYSTEM THROUGH DIVERSION AND RESTORATIVE JUSTICE POLICY
Authors: Listyarini Dyah 
Published: August 2018

Indonesia as a state of law has ratified several international human rights instruments, especially the Convention on the Rights of the Child, in which the state should ensure the protection, respect, fulfillment, promotion, and enforcement of children's rights. In fact, many children have been treated unjustly in the fulfillment of their rights when conflicting with the law. Methods of legal protection of the rights of children conflicting with the law are based on the provision that “every child has the right to survive, grow and develop as well as the right to protection from violence and discrimination”. Other ways to protect children’s rights may also include the policy that children conflicting with the law should be treated humanely in accordance with their dignity and rights; special personnel should be provided for their companion and counseling; sanctions should be appropriated for the best interests of the children; and special facilities and infrastructure for children should be equally provided. This means that appropriate sanctions should hence be supported through the process of resolving cases using the principle of “diverse and restorative justice The concept of diverse and restorative justice can be applied to the crime of under 7th-year punishments and non-repeated crime. Methods for handling children who have conflicts with the law have hitherto emphasized on normative juridical processes such as investigation, prosecution, and examination of the case by the judge (in court). The processes, however, have not guidelines or technical manuals for law enforcement officers to implement the non-litigation settlement for children cases
Environmental Sustainability Analysis as a Competitive Strategy in the Hotel Industry of Sinaloa, Mexico
Authors: López-Illán Beatriz , Ibarra-Michel Juan Pedro 
Published: August 2018

AbstractThis case study analyses characteristics of the implementation of environmental strategies in hotels. Results were found to be highly variable between hotels. They also highlight the need for greater momentum for this new type of business model. For the development of this research, a multi-method study approach was adopted, with a mixed methodology to the hotel industry of the state of Sinaloa, Mexico. This was done through executive interviews in addition to the application of a compliance guide to 11 companies selected from the sector. Relevant aspects are considered through a review of the hotel sector and sustainability, consumer trends, sustainability in the tourism market and development phases for corporate sustainability.
Help or Hindrance? Outside Group Advertising Expenditures in House Races
Authors: Baker Anne E. 
Published: August 2018

Abstract
Super PACs, 501(c)4 social welfare organizations, and 501(c)6 professional associations are now major spenders in House elections. What remains unclear is how the strategic expenditure choices of these respective outside interest groups impact the competitive position of non-incumbent candidates running for the House – specifically do their advertising expenditures undermine or augment the expenditures made by the campaign. Using the Wesleyan Media Project datasets of 2012 and 2014 in combination with campaign finance data in a series of models, I find early television advertising expenditures by the aforementioned 501(c) dark money organizations diminish the effectiveness of non-incumbents’ campaign expenditures – both on television advertising and in general – whereas super PACs’ early television advertising expenditures have no significant impact on campaign spending. A comparison of 501(c) dark money organizations’ and super PACs’ advertising choices in 2012 and 2014 reveals these differential effects likely relate to legal constraints leading 501(c)s, and not super PACs, to devote more resources toward policy advertisements early in the general election cycle. I argue this choice by 501(c) s makes it difficult for non-incumbents’ campaigns to shape the policy agenda early in the race leading the campaign’s expenditures on television advertising and the campaign’s total disbursements to be less effective in terms of improving the candidate’s competitiveness.
Optimization of the biological synthesis of silver nanoparticles using Penicillium oxalicum GRS-1 and their antimicrobial effects against common food-borne pathogens
Authors: Rose Gaurav Kumar , Soni Raman , Rishi Praveen , Soni Sanjeev Kumar 
Published: August 2018

Abstract
Biologically synthesized nanoparticles are gaining importance as they offer several advantages, such as the ease with which they can be scaled up, the cost-effectiveness of the process and the green route of production. In this study, silver (Ag) nanoparticles were biosynthesized using the cellular extract of Penicillium oxalicum GRS-1 and then characterized by ultraviolet visible spectroscopy, X-ray diffraction, field emission scanning electron microscopy, transmission electron microscopy (TEM) and Fourier transform infrared spectroscopy. The biosynthesis of nanoparticles was optimized by following the one factor at a time approach, wherein the temperature of 60°C, pH 7.0 and 1.5 mm silver nitrate (AgNO3) concentration were found to be most favorable factors for the production of Ag nanoparticles. Upon statistical optimization, the maximum production of Ag nanoparticles with a concentration of 136 ppm was achieved at pH 7.2, AgNO3 concentration 1.975 mm and 86 h using the crude cellular extract of P. oxalicum GRS-1 having nitrate reductase activity. TEM analysis showed that the Ag nanoparticles were spherical in shape with sizes ranging from 10 to 40 nm. The biosynthesized nanoparticles showed strong antimicrobial activity against the common food-borne, pathogens including Staphylococcus aureus, Escherichia coli and Salmonella typhimurium with respective minimum bactericidal concentrations of 32, 16 and 32 μg/ml.
Superficial intersubjectivity in ELF university dormitory interactions
Authors: Siegel Aki 
Published: August 2018

AbstractThe current study investigates the phenomena of “superficial intersubjectivity” occurring in English as a lingua franca (ELF) interactions at an international university dormitory in Japan. “Intersubjectivity” (Rommetveit, Ragnar. 1976. On the architecture of intersubjectivity. In Ragnar Rommetveit & Rolv Mikkel Blakar [eds.],Studies of language, thought, and verbal communication, 93–107. New York: Academic Press) refers to the shared perspective of the social world by the interlocutors. In ELF interactions where shared perspectives cannot be presumed, efforts to achieve intersubjectivity are critical. ELF research has explicated speakers’ efforts and cooperativeness to achieve intersubjectivity or avoid misunderstandings during interactions (Kaur, Jagdish. 2011a. “Doing being a language expert”: The case of the ELF speaker. In Alasdair Archibald, Alessia Cogo & Jennifer Jenkins [eds.],Latest Trends in ELF Research, 53–75. Newcastle upon Tyne: Cambridge Scholars Publishing; Seidlhofer, Barbara. 2001. Closing a conceptual gap: The case for a description of English as a lingua franca.International Journal of Applied Linguistics11[2]. 133–158). However, few studies have investigated cases where speakers display mutual understanding during a repair sequence even when the understanding is not accurate.Approximately 37 hours of naturally occurring ELF interactions were collected and analyzed using a standard conversation analysis followed by a post-analytic researcher observation. Detailed analyses of repair sequences regarding a word suggest that in non-institutional ELF interactions the accuracy of intersubjectivity is not always prioritized. Rather, statements made by the speaker positioned as the one with relatively stronger linguistic ability seem to hold influence over the repair sequence, which prompts the interlocutor with relatively weaker ability to agree with inaccurate candidate understandings. The study suggests a connection between the positioning of speakers regarding linguistic knowledge and the construction of intersubjectivity in ELF interactions.
PIR-PSI: Scaling Private Contact Discovery
Authors: Demmler Daniel , Rindal Peter , Rosulek Mike , Trieu Ni 
Published: August 2018

AbstractAn important initialization step in many social-networking applications is contact discovery, which allows a user of the service to identify which of its existing social contacts also use the service. Naïve approaches to contact discovery reveal a user’s entire set of social/professional contacts to the service, presenting a significant tension between functionality and privacy. In this work, we present a system forprivatecontact discovery, in which the client learnsonlythe intersection of its own contact list and a server’s user database, and the server learns only the (approximate) size of the client’s list. The protocol is specifically tailored to the case of a small client set and large user database. Our protocol has provable security guarantees and combines new ideas with state-of-the-art techniques from private information retrieval and private set intersection.We report on a highly optimized prototype implementation of our system, which is practical on real-world set sizes. For example, contact discovery between a client with 1024 contacts and a server with 67 million user entries takes 1.36 sec (when using server multi-threading) and uses only 4.28 MiB of communication.
Sorption of Eu(III) on Fe–montmorillonite relevant to geological disposal of HLW
Authors: Chikkamath Santosh , Patel Madhuri A. , Kar Aishwarya S. , Raut Vaibhavi , Tomar Bhupendra Singh , Manjanna Jayappa 
Published: August 2018

Abstract
Montmorillonite (Mt) is the major clay mineral of bentonite, which is the candidate buffer material in the engineered barrier system for geological disposal of high level waste (HLW). The alteration of Mt due to its interaction with carbon steel (overpack) can produce Fe–Mt. In order to understand the basic properties of Fe–Mt, the sorption studies using Eu(III) are reported here. For this, Fe(III)–Mt was prepared by conventional cation exchange method using FeCl3 with Na–Mt. The obtained Fe(III)–Mt was then reduced to Fe(II)–Mt using ascorbic acid. Both the samples were characterized based on their X-ray diffraction, Fourier transform infrared spectra, cation exchange capacity and specific surface area. The batch sorption studies of Eu(III) were conducted for both Fe(III)–Mt and Fe(II)–Mt as a function of pH (3–10), ionic strength (0.001 M–1 M) and Eu(III) concentration (10−8–10−3 M). The distribution coefficient (Kd) was found to be higher for Fe(III)–Mt compared to Fe(II)–Mt and Na–Mt. The sudden increase in sorption in the pH range 4.5–6 and remaining constant beyond it indicates ion exchange mechanism at pH<4.5, with surface complexation mechanism dominating the sorption at pH>4.5. This is further corroborated by ionic strength dependent sorption data which shows decrease in sorption capacity of Fe–Mt with increasing ionic strength at low pH, but remaining more or less unchanged at higher pH. Eu(III) adsorption isotherm on Fe–Mt increased linearly with [Eu(III)] reaching saturation at 10−5 M and 10−4 M for Fe(III)–Mt and Fe(II)–Mt, respectively. The amount of iron released from Fe–Mt and Fe(II)/Fetotal during sorption were estimated to understand the effect on Eu(III) sorption behaviour by release of interlayer iron in Fe–Mt.
Pacing Strategy of a Full Ironman Overall Female Winner on a Course With Major Elevation Changes
Authors: Pryor J. Luke , Adams William M. , Huggins Robert A. , Belval Luke N. , Pryor Riana R. , Casa Douglas J. 
Published: August 2018

Abstract
Pryor, JL, Adams, WM, Huggins, RA, Belval, LN, Pryor, RR, and Casa, DJ. Pacing strategy of a full Ironman overall female winner on a course with major elevation changes. J Strength Cond Res 32(11): 3080–3087, 2018—The purpose of this study was to use a mixed-methods design to describe the pacing strategy of the overall female winner of a 226.3-km Ironman triathlon. During the race, the triathlete wore a global positioning system and heart rate (HR)-enabled watch and rode a bike outfitted with a power and cadence meter. High-frequency (every km) analyses of mean values, mean absolute percent error (MAPE), and normalized graded running pace and power (accounting for changes in elevation) were calculated. During the bike, velocity, power, cadence, and HR averaged 35.6 km·h−1, 199 W, 84 rpm, and 155 b·min−1, respectively, with minimal variation except for velocity (measurement unit variation [MAPE]: 7.4 km·h−1 [20.3%], 11.8 W [7.0%], 3.6 rpm [4.6%], 3 b·min−1 [2.3%], respectively). During the run, velocity and HR averaged 13.8 km·h−1 and 154 b·min−1, respectively, with velocity varying four-fold more than HR (MAPE: 4.8% vs. 1.2%). Accounting for elevation changes, power and running pace were less variable (raw [MAPE] vs. normalized [MAPE]: 199 [7.0%] vs. 204 W [2.7%]; 4:29 [4.8%] vs. 4:24 min·km−1 [3.6%], respectively). Consistent with her planned pre-race pacing strategy, the triathlete minimized fluctuations in HR and watts during the bike and run, whereas velocity varied with changes in elevation. This case report provides observational evidence supporting the utility of a pacing strategy that allows for an oscillating velocity that sustains a consistent physiological effort in full Ironman races.