bluuebunny/crossref_metadata_2025_split huggingface dataset:
Increasing plasma ADAMTS13 activity is associated with HBeAg seroconversion in chronic hepatitis B patients during 5 years of entecavir treatment
Authors: Guo Renyong , Xie Yirui , Yang Jiezuan , Lu Haifeng , Ye Ping , Jin Linfeng , Lin Wenqin 
Published: April 2019

AbstractThe relationship between hemostatic system and HBeAg seroconversion (SC) of chronic hepatitis B (CHB) patients is ill-defined. We therefore evaluate the predictive value of plasma ADAMTS13 (a disintegrin and metalloproteinase with a thrombospondin motif repeats 13) and VWF (von Willebrand factor) for CHB patients during 5-year entecavir (ETV) treatment. One hundred and fourteen HBeAg positive CHB patients on continuous ETV treatment were recruited. Liver biopsies were evaluated using the METAVIR scoring system, and plasma ADAMTS13 activity (ADAMTS13: AC) and VWF antigen (VWF: Ag) were determined at baseline, 3, 12, 24, 36, and 60 months, respectively. ETV treatment resulted in an increased ADAMTS13: AC and decreased VWF: Ag (both P < 0.001) in CHB patients. Cox multivariate analysis demonstrated that the change of ADAMTS13: AC after 1-year ETV treatment was an independent predictor for HBeAg SC at year 5. The area under the receiver operating characteristic (ROC) curve for the change of ADAMTS13: AC after 1-year ETV treatment plus baseline HBV DNA was 0.873 (P < 0.001) to predict SC at year 5. The results suggested that increased ADAMTS13: AC after 1 year ETV treatment was associated with a higher seroconversion, and could be used surrogate of HBeAg SC in CHB patients during 5-year ETV treatment.
Novel multilayer TiO2 heterojunction decorated by low g-C3N4 content and its enhanced photocatalytic activity under UV, visible and solar light irradiation
Authors: Wang Yizheng , Yu Jiang , Peng Weidong , Tian Jing , Yang Chun 
Published: April 2019

AbstractIn this paper, we used a facile ball milling, microwave radiation and heating treatment method to achieve the surface modification of TiO2 with low g-C3N4 concentration, and a multilayer heterojunction composite with TiO2 as the main part and g-C3N4 as the modification agent was obtained. The obtained materials were analyzed by several characterizations to get information on their chemical composition, crystalline structure, vibrational features and optical properties. The photocatalytic performance was evaluated by degradation of rhodamine B (RhB) and methylene blue (MB) under UV, visible and direct solar light irradiation. Its photocatalytic activity was enhanced depended on the novel structure of g-C3N4/TiO2 hybrid and the special Z-scheme electron-hole transfer model of multilayer heterointerfaces. The material preparation and structural features could be useful for the design and development of other photocatalysts with high photocatalytic activity.
Extent of Resection in Meningioma: Predictive Factors and Clinical Implications
Authors: Lemée Jean-Michel , Corniola Marco V. , Da Broi Michele , Joswig Holger , Scheie David , Schaller Karl , Helseth Eirik , Meling Torstein R. 
Published: April 2019

AbstractMeningiomas present as intracranial extra-axial lesions with dural attachment, which are primarily managed surgically. The extent of resection (EOR) may vary depending on patient- and tumor-related factors. The aim of this study is to identify preoperative predictive factors of EOR and to propose an estimation of the predicted gross total resection (GTR) based of patient- and tumor-characteristics. 1469 patients from a retrospectively (1990 to 2002) and prospectively managed (2003 to 2010) databank of Oslo University Hospital, Norway, totalling 11,414 patient-years of follow-up were included. Patients had a mean age at surgery of 64 ± 20.1 years with a female-to-male ratio was 2.4:1 and a mean KPS of 81.2 ± 12.1. Skull-base meningiomas represented 47% of all cases. WHO grades were I in 92.3%, II in 5.2%, and III in 2.2%. Bone infiltration was described in 18.7% of cases. 39.3% of patients had Simpson I resection, 34.3% had Simpson II, 5.4% had Simpson III, 20.6% had Simpson IV, and 0.5% had Simpson V. The risk factors for incomplete resection were: symptomatic presentation (OR 0.56 [0.43–0.72]), skull-base location (OR 0.79 [0.70–0.88]), and bone invasion (OR 0.85 [0.73–0.99]). Using a recursive partitioning analysis, we propose a classification-tree for the prediction of GTR rate based on preoperatively determinable patient- and tumor characteristics. The identification of preoperative predictors of poor GTR rate may aid clinicians managing meningioma patients. In selected cases were the predicted GTR rate is low, staged treatment with surgical debulking followed by adjuvant therapy may be favored in order to minimize postoperative morbidity and mortality.
Hybrid Telecoaching for Corporate Speech Training and Potential Applications to Clinical Practice
Authors: Burke Thomas F. 
Published: April 2019

Purpose
The purpose of this article was to describe a model for “hybrid speech telecoaching” developed for a Fortune 100 organization and offer a “thought starter” on how clinicians might think of applying these corporate strategies within future clinical practice.

Conclusion
The author contends in this article that corporate telecommunications and best practices gleaned from software development engineering teams can lend credibility to e-mail, messaging apps, phone calls, or other emerging technology as viable means of hybrid telepractice delivery models and offer ideas about the future of more scalable speech-language pathology services.
Krebserkrankung und das letzte Lebensjahr: Palliative Leistungen, Krankenhausaufenthalte und Sterbeort
Authors: Blaschke Katja , Hermes-Moll Kerstin , Lappe Veronika , Ihle Peter , Baumann Walter , Schubert Ingrid 
Published: April 2019

Zusammenfassung
Einleitung Palliativ versorgte Patientinnen und Patienten haben zu einem hohen Anteil onkologische Diagnosen. Die spezialisierte ambulante Palliativversorgung (SAPV) richtet sich an Erkrankte mit komplexem Symptomgeschehen und intensivem Betreuungsbedarf und soll eine Betreuung im häuslichen Umfeld bis zum Lebensende ermöglichen. In Hessen wurden ab 2009 die ersten SAPV-Angebote geschaffen. Entsprechend untersucht diese Studie (i) die Inanspruchnahme von SAPV und spezialisierten stationären palliativen Leistungen im letzten Lebensjahr von Krebserkrankten, (ii) die SAPV verordnende Arztgruppe und (iii) den Sterbeort und Krankenhausaufenthalte in den letzten 91 Lebenstagen.
Methoden In der retrospektiven Sekundärdatenanalyse wurden Daten der AOK Hessen für 2009–2014 deskriptiv ausgewertet. Studienpopulation waren an Brust-, Prostata- oder Darmkrebs Erkrankte, die im jeweiligen Beobachtungsjahr (2010–2014) verstarben und 360 Tage vor ihrem Tod durchgängig versichert waren.
Ergebnisse In die Studie konnten je nach Beobachtungsjahr 492–545 Personen mit Brust-, 546–625 mit Prostata- und 709–752 mit Darmkrebs eingeschlossen werden. In allen 3 Gruppen Krebserkrankter stieg zwischen 2010 und 2014 der Anteil mit Inanspruchnahme von mindestens einer Palliativleistung. Die Häufigkeit der Inanspruchnahme von SAPV-Leistungen lag bei den betrachteten Krebserkrankten meist höher im Vergleich zu Palliativstationen bzw. stationären Hospizen. SAPV wurde bei den 3 Krebsdiagnosen zu über 90% von Hausärztinnen bzw. -ärzten verordnet. Sowohl der Anteil von Personen mit einem Krankenhausaufenthalt in den letzten 91 Lebenstagen als auch der im Krankenhaus Verstorbenen ging von 2010 bis 2014 bei allen 3 Krebsarten zurück.
Schlussfolgerung Die Ergebnisse sind vor dem Hintergrund des Aufbaus der SAPV in Hessen zu bewerten. Die Zunahme an SAPV-Leistungen und der Rückgang an Krankenhauseinweisungen am Lebensende weist auf eine gelungene Etablierung der SAPV in Hessen hin.
Gesunde Städte
Authors: Knöll Martin 
Published: April 2019

Zusammenfassung
Menschen mit Diabetes wissen, dass für gute Blutzuckerwerte an manchen Tagen viele Faktoren zusammenkommen müssen: Ausgewogenes Essen, Broteinheiten richtig einschätzen, wenig Stress, keine Erkältung, und ausreichend Bewegung. Ein Faktor, der bisher wenig Beachtung findet, ist die gebaute Umwelt. Damit bezeichnet man die Gesamtheit der von Menschen gestalteten Umgebung wie Wohnungen, Büros, Universitäten, Parks, Plätze und Straßenräume. Experten schätzen den Anteil der Gesundheit, der durch die gebaute Umwelt erklärt werden kann, auf 20 bis 25 %. In der renommierten Zeitschrift „The Lancet“ haben Wissenschaftler kürzlich Beweise dafür zusammengetragen, wie Städte – jahrzehntelang für die Belange des Autos geplant – durch Lärm und Luftverschmutzung, inaktive Lebensstile, ungesunde Nahrungsgewohnheiten, Unfälle und soziale Isolation die Gesundheit ihrer Bewohner gefährden 1. In Kopenhagen oder Wien dagegen, Vorreiter einer neuen Welle von „menschengerechter Stadtplanung“, sind die Bewohner häufiger zu Fuß oder mit dem Fahrrad unterwegs. Dies wirkt sich positiv auf deren Gesundheit aus.
Umstellung auf Insulin bei Typ-2-Diabetes
Authors: Borchert Peter 
Published: April 2019

ZUSAMMENFASSUNGDer Einstieg in die Insulintherapie ist alles andere als eine lineare, eindimensionale Herausforderung: Insulin löst beim Patienten nicht selten eine schwere Lebenskrise aus, mit ganz individuellen Sorgen und Anliegen. Eine Insulintherapie braucht die Motivation des Patienten zur eigenständigen Therapie(durch)führung. Die meiste Zeit entscheidet und handelt er in seinem Alltag allein. Erst, wenn dem Patienten seine Bedenken genommen werden können, ist eine bewusste und nachhaltige Entscheidung für die Insulintherapie möglich. Statt einem eindeutigen Ja oder Nein zur Therapie bewegen den Patienten ambivalente Überlegungen. Natürlich ist dem Menschen seine Gesundheit wichtig, aber er verwaltet immer auch seine Gesamtgesundheit. Im ärztlichen Gespräch sollten diese Ambivalenzen exploriert und verbalisiert werden. Das Gefühl der Autonomie motiviert. Entscheidungsspielräume stärken die Autonomie und unterstützen die patienteneigene Entscheidungsfindung. Schulung gibt Sicherheit und reduziert Angst. Ein Fertigkeitstraining stärkt die erlebte Selbstwirksamkeit und sichert die Therapieumsetzung wesentlich. Wir verfügen über gemeinsame, qualitätsgesicherte Leitfäden zum Fertigkeitstraining. Schulung und Anleitung sollten sofort, zum Zeitpunkt der Therapieentscheidung bereitstehen. Modulare Schulungskonzepte ermöglichen die dafür notwendige Flexibilität. Hier liegen die Schulungskonzepte der Zukunft.
Effectiveness of a dynamic usage based computer assisted language program
Authors: Irshad Mufeeda , Keijzer Merel , Wieling Martijn , Verspoor Marjolijn 
Published: April 2019

Abstract
The current paper explores whether a Dynamic Usage Based (DUB) approach – which takes authentic meaningful
language use with repetition and scaffolding for comprehension as its basis – can also be implemented in a CALL environment. The
effectiveness of the DUB-CALL program was tested in a semester-long experiment, comparing it with a teacher-fronted DUB program
(using the same materials as the CALL program) and a traditional CLT program; 228 university undergraduates in Sri Lanka
participated. Language gains were assessed in a pre-post design with an objective General English Proficiency (GEP) test and a
writing task. The results show that the students in the DUB-CALL condition performed significantly better on the GEP test than the
students in the two teacher-fronted classes. The results of the writing tests show that all groups improved significantly, but
here there were no differences among groups.
Eighth graders’ expository text comprehension
Authors: Welie Camille , Schoonen Rob , Kuiken Folkert 
Published: April 2019

Abstract
The present study examined whether ten motivations to read
expository texts moderated the effects of cognitive skills on eighth graders’
expository text comprehension, while accounting for the main effects of
cognitive skills. Furthermore, it was examined whether the effect of
motivational dimensions on expository text comprehension differed between
monolingual and bilingual Dutch students, and between poor and good readers.
Hundred fifty-two eighth graders took tests measuring their expository text
comprehension, sentence reading fluency, linguistic knowledge, metacognitive
knowledge and motivations to read expository texts. None of ten motivational
aspects did moderate the effect of cognitive skills on expository text
comprehension. Furthermore, there were no differences between monolingual and
bilingual Dutch students, or between poor and good readers, in terms of the
relationship between motivational dimensions and expository text comprehension.
Differences between our findings and results from other studies are interpreted
in the context of measurement specificity and the school system.
The limitations of accommodation: the changing legal context of religion at work in the United States
Authors: Phipps  
Published: April 2019

Other authors have warned that the legal standard of accommodation is insufficient as a strategy for practicing managers leading religiously and spiritually diverse workforces. Recent changes in the legal context of faith at work have only amplified those concerns. This article examines
the adoption of state laws known as Religious Freedom Restoration Acts, or RFRA’s, as well as the US Supreme Court ruling in Burwell v. Hobby Lobby. Both of these changes exacerbate the concerns previously articulated, and illustrate the limitations of using the legal standard of
accommodation as a management strategy for negotiating diverse religious and spiritual expression in the workplace. The nature of these two developments is explained, together with a discussion of their significance for practitioners and researchers in the field of management, spirituality,
and religion (MSR).
Exosomes from N‐Myc amplified neuroblastoma cells induce migration and confer chemoresistance to non‐N‐Myc amplified cells: implications of intra‐tumour heterogeneity
Authors: Fonseka Pamali , Liem Michael , Ozcitti Cemil , Adda Christopher G. , Ang Ching‐Seng , Mathivanan Suresh 
Published: April 2019

ABSTRACTNeuroblastoma accounts for 15% of childhood cancer mortality. Amplification of the oncogene N‐Myc is a well‐established poor prognostic marker for neuroblastoma. Whilst N‐Myc amplification status strongly correlates with higher tumour aggression and resistance to treatment, the role of N‐Myc in the aggressiveness of the disease is poorly understood. Exosomes are released by many cell types including cancer cells and are implicated as key mediators in cell‐cell communication via the transfer of molecular cargo. Hence, characterising the exosomal protein components from N‐Myc amplified and non‐amplified neuroblastoma cells will improve our understanding on their role in the progression of neuroblastoma. In this study, a comparative proteomic analysis of exosomes isolated from cells with varying N‐Myc amplification status was performed. Label‐free quantitative proteomic profiling revealed 968 proteins that are differentially abundant in exosomes released by the neuroblastoma cells. Gene ontology‐based analysis highlighted the enrichment of proteins involved in cell communication and signal transduction in N‐Myc amplified exosomes. Treatment of SH‐SY5Y cells with N‐Myc amplified SK‐N‐BE2 cell‐derived exosomes increased the migratory potential, colony forming abilities and conferred resistance to doxorubicin induced apoptosis. Incubation of exosomes from N‐Myc knocked down SK‐N‐BE2 cells abolished the transfer of resistance to doxorubicin induced apoptosis. These findings suggest that exosomes could play a pivotal role in N‐Myc‐driven aggressive neuroblastoma and transfer of chemoresistance between cells.Abbreviations: RNA = ribonucleic acid; DNA = deoxyribonucleic acid; FCS = foetal calf serum; NTA = nanoparticle tracking analysis; LC‐MS = liquid chromatography–mass spectrometry; KD = knockdown; LTQ = linear trap quadropole; TEM = transmission electron microscopy
Risk measures and the distribution of damage curves for 600 European coastal cities
Authors: Abadie L M , Galarraga I , Markandya A , Sainz de Murieta E 
Published: April 2019

Abstract
A good understanding of climate change damages is vital to design effective adaptation policies and measures. Using a dataset of probabilistic sea-level rise and other of flood damages and protection cost curves for the 600 largest European coastal cities we generate stochastic damage curves and their distributions with and without adaptation. We apply the Generalized Extreme Value distribution to characterize the distributions and calculate two risk measures: the Value at Risk and the Expected Shortfall, which contribute to understanding the magnitude and probability of high-end sea-level rise represented by the upper tail of the distribution. This allows the costs of sea-level rise to be estimated (that is, in addition to other costs related to coastal extreme events) and supports decision-makers in integrating the high uncertainty related to future projections. This knowledge is necessary for an adequate risk management that does not underestimate risk. Furthermore, it allows city planners to tailor their risk tolerance. A great number of cities in Europe are currently undertaking adaptation plans or have already done so. Making these findings available should therefore be of great priority value to inform these processes.
Innovative consumers: ecological, behavioral, and physiological predictors of responses to novel food
Authors: Prasher Sanjay , Thompson Megan J , Evans Julian C , El-Nachef Michael , Bonier Frances , Morand-Ferron Julie 
Published: April 2019

AbstractConsumer innovation, that is, the acquisition and consumption of novel food types, has received little attention, despite its predominance among animal innovations and its potential implications for the ecology and evolution of species in a changing world. Results of the few studies that have investigated individual responses to novel foods suggest that various ecological, behavioral, and physiological variables may affect individual propensity for consumer innovation, but further work is needed to clarify these relationships. We investigated whether urbanization, social rank, exploratory personality, and baseline levels of corticosterone predict food neophobia and consumer innovation responses of wild-caught black-capped chickadees (N = 170) from 14 sites along an urbanization gradient. Our analyses do not support a link between food neophobia or consumer innovation and urbanization, dominance, or exploratory personality. However, birds with higher levels of baseline corticosterone were quicker to contact novel food types, and more likely to consume novel foods than individuals with lower levels of the hormone. This finding suggests that physiological states that promote foraging behavior might drive individual responses to novel food. Additionally, we found that chickadees tested later in autumn were less neophobic than those tested earlier in the season, perhaps reflecting seasonal changes in food availability. Together, the ability of baseline corticosterone and date of capture to predict responses to novel food suggest that necessity may drive consumer innovation in chickadees.
Discovering novel mutation signatures by latent Dirichlet allocation with variational Bayes inference
Authors: Matsutani Taro , Ueno Yuki , Fukunaga Tsukasa , Hamada Michiaki 
Published: April 2019

Abstract

Motivation
A cancer genome includes many mutations derived from various mutagens and mutational processes, leading to specific mutation patterns. It is known that each mutational process leads to characteristic mutations, and when a mutational process has preferences for mutations, this situation is called a ‘mutation signature.’ Identification of mutation signatures is an important task for elucidation of carcinogenic mechanisms. In previous studies, analyses with statistical approaches (e.g. non-negative matrix factorization and latent Dirichlet allocation) revealed a number of mutation signatures. Nonetheless, strictly speaking, these existing approaches employ an ad hoc method or incorrect approximation to estimate the number of mutation signatures, and the whole picture of mutation signatures is unclear.

Results
In this study, we present a novel method for estimating the number of mutation signatures—latent Dirichlet allocation with variational Bayes inference (VB-LDA)—where variational lower bounds are utilized for finding a plausible number of mutation patterns. In addition, we performed cluster analyses for estimated mutation signatures to extract novel mutation signatures that appear in multiple primary lesions. In a simulation with artificial data, we confirmed that our method estimated the correct number of mutation signatures. Furthermore, applying our method in combination with clustering procedures for real mutation data revealed many interesting mutation signatures that have not been previously reported.

Availability and implementation
All the predicted mutation signatures with clustering results are freely available at http://www.f.waseda.jp/mhamada/MS/index.html. All the C++ source code and python scripts utilized in this study can be downloaded on the Internet (https://github.com/qkirikigaku/MS_LDA).

Supplementary information
Supplementary data are available at Bioinformatics online.
Lookback-Guess-Next Optimizer: Feedback-Guided Random Search Technique with Biased Mapping for Solving Unconstrained Optimization Problems
Authors: Al-Muhammed Muhammed Jassem 
Published: April 2019

Abstract
Finding global optima for functions is a very important problem. Although a large number of methods have been proposed for solving this problem, more effective and efficient methods are greatly required. This paper proposes an innovative method that combines different effective techniques for speeding up the convergence to the solution and greatly improving its precision. In particular, the method uses feedback-guided random search technique to identify the promising regions of the domains and uses the biased mapping technique to focus the search on these promising regions, without ignoring the other regions of the domains. Therefore, at any point of time, the domain of each variable is entirely covered with much more emphasis on the promising regions. Experiments with our prototype implementation showed that our method is efficient, effective, and outperformed the state-of-art techniques.
Web elements for health promotion in Malaysia
Authors: Noman Marwan , Koo Ah Choo , Tee Sim Hui , Krishnan Manimaran 
Published: April 2019

Abstract
The needs for health promotion is increasingly important for Malaysian. Government invests in the development to improve health education. Malaysia lacks the development of online solutions to help to maintain the health of the nation through prevention and mass education. This paper addresses important questions about the development of those health promotion websites by considering the motivation of web elements. It seeks to provide information on the barriers to the use and success as a method of health promotion. The empirical work is a perceptions study that aims to identify the barriers of web-based health promotion in the different user characteristics for health promotion purposes. This work is a qualitative research project directed at ascertaining the perceptions of Malaysians concerning the use of health promotion websites. It pertains to those factors which stop the uptake of website use and seeks to discern the views of users on how the health promotion websites may be more engaging. The principal finding is that the ethnicity of the user is mainly relevant in terms of the socio-economic status of the user. Users across all ethnicities respond to the same qualities of websites. The same web elements are motivating to users regardless of the characteristics of the users because the uptake of the Internet and the use of websites for health promotion has been more a phenomenon of the young. The study concludes with some recommendations for the Ministry of Health and the developers of health promotion websites in Malaysia.