bluuebunny/crossref_metadata_2025_split huggingface dataset:
Temperature and photoperiod differentially impact maternal phenotypes in diapause egg-laying Aedes albopictus mosquitoes
Authors: Lee In Hae , Lee Anthony S. , Kogan Helen V. , Dong Linhan , Duvall Laura B. 
Published: October 2024

Background
Aedes albopictus (Skuse 1894) mosquitoes can transmit deadly arboviruses and are globally invasive due to their ability to survive in both tropical and temperate climates. Although adults cannot survive harsh winters, females are capable of anticipating seasonal change and producing overwintering diapause (DP) eggs that remain in a state of arrested development over the winter and hatch when favorable conditions return in the spring. While low temperatures can facilitate DP entry under short photoperiods, temperature signals alone are not sufficient to induce DP.

Methodology/Principal findings
To identify maternal phenotypes predictive of DP egg production in laboratory conditions, we characterized aspects of maternal physiology and behavior to identify those that correlate with DP egg production and changes in photoperiod, versus changes in temperature. Neither changes in temperature nor photoperiod impacted protein preference, blood meal consumption, or total number of eggs produced per female. Egg retention and oviposition timing were influenced by temperature, independent of DP egg production. However, females housed under short photoperiod conditions showed increased starvation resistance, despite showing similar levels of locomotor activity and internal stores of triacylglycerols, glucose, glycogen, and trehalose compared to females housed in long photoperiods.

Conclusions/Significance
These results suggest that temperature and photoperiod differentially affect maternal phenotypes and identify starvation resistance as a maternal phenotype that is influenced by photoperiod and correlates with DP egg status.
A change in circulating chikungunya virus variant impacts Aedes aegypti vector competence and spatiotemporal distribution of disease in Malaysia
Authors: Azman Izzati Kausar , Chan Yoke Fun , Chua Chong Long , Abd Mutalib Zainal Abidin , Dass Sarat Chandra , Gill Balvinder Singh , Ismail Nor Hayati , Jelip Jenarun , Wan Ming Keong , Lee Wenn-Chyau , Vythilingam Indra , Alphey Luke , Sam I-Ching 
Published: October 2024

Background
In 2008–2010, Malaysia experienced a nationwide chikungunya virus (CHIKV) outbreak caused by the Indian Ocean lineage E1-226V (valine) variant, adapted to Aedes albopictus. In 2017–2022, transition to an E1-226A (alanine) variant occurred. Ae. albopictus prevails in rural areas, where most cases occurred during the E1-226V outbreak, while Ae. aegypti dominates urban areas. The shift in circulating CHIKV variants from E1-226V to E1-226A (2009–2022) was hypothesized to result in a transition from rural to urban CHIKV distribution, driven by differences in Ae. aegypti vector competence for the two variants. This study aimed to: (1) map the spatiotemporal spread of CHIKV cases in Malaysia between 2009–2022; and (2) compare replication of E1-226A and E1-226V variants in the midguts and head/thoraxes of Ae. aegypti.

Methodology/Principal findings
Spatiotemporal analysis of national notified CHIKV case addresses was performed. Between 2009–2022, 12,446 CHIKV cases were reported, with peaks in 2009 and 2020, and a significant shift from predominantly rural cases in 2009–2011 (85.1% rural), to urban areas in 2017–2022 (86.1% urban; p<0.0001). Two Ae. aegypti strains, field-collected MC1 and laboratory Kuala Lumpur (KL) strains, were fed infectious blood containing constructed CHIKV clones, pCMV-p2020A (E1-226A) and pCMV-p2020V (E1-226V) to measure CHIKV replication by real-time PCR and/or virus titration. The pCMV-p2020A clone replicated better in Ae. aegypti cell line Aag2 and showed higher replication, infection and dissemination efficiency in both Ae. aegypti strains, compared to pCMV-p2020V.

Conclusions/Significance
This study revealed that a change in circulating CHIKV variants can be associated with changes in vector competence and outbreak epidemiology. Continued genomic surveillance of arboviruses is important.
Effects of a digital self-efficacy training in stressed university students: A randomized controlled trial
Authors: Rohde Judith , Marciniak Marta A. , Henninger Mirka , Homan Stephanie , Ries Anja , Paersch Christina , Friedman Olivia , Brown Adam D. , Kleim Birgit 
Published: October 2024

Objective
Self-efficacy is associated with positive mental health outcomes. We developed and tested a digital self-efficacy training for daily recall of autobiographical self-efficacy memories (e.g., memories of successfully overcoming a personal challenge).

Method
In this randomized controlled trial, we investigated the effects of the week-long digital self-efficacy training on key mental health outcomes, including anxiety, stress, and hopelessness, and on self-efficacy in 93 university students (mean age 23.3 years, SD: 3.49) with elevated self-reported stress levels. Participants completed either the self-efficacy training combined with ecological momentary assessment (EMA) (training group) or EMA only (control group).

Results
We found significantly reduced hopelessness and trait anxiety in the training group compared to the control group at post-assessment (one day post intervention). Effects on ratings of self-efficacy at post-assessment were also significant when controlling for baseline self-efficacy.

Conclusions
This stand-alone digital self-efficacy training was significantly associated with a number of positive effects on outcomes compared to a control condition, including reduced hopelessness, trait anxiety, and increased self-efficacy. Future work is needed to replicate and investigate the long-term effects of the training and explore its implementation in clinical populations.

Trial registration
ClinicalTrials.gov Identifier: NCT05617248
Assessment of knowledge and perception of prescribers towards rational medicine use in the Ashanti Region of Ghana
Authors: Djochie Richard Delali Agbeko , Owusu-Donkor Rita , d’Almeida Elizabeth Modupe , Gyamfi Akwah Francis Kwadwo , Kyeremateng Emmanuel , Opoku-Afriyie Samuel , Tabiri Cecilia Akosua , Kyei-Frimpong Francis , Dwomoh Samuel , Boakye-Yiadom Jonathan 
Published: October 2024

Background
Prescribers must possess extensive knowledge and maintain a positive attitude towards the rational use of medicines to achieve desirable treatment outcomes and effectively prevent treatment failures, increased costs, drug toxicities, and interactions. The objective of this study was to evaluate prescribers’ understanding and perception concerning the rational use of medicines in public hospitals. Additionally, the study aimed to identify the factors that influence rational prescribing practices.

Methods
A structured data instrument was developed to collect demographic data and evaluate participants’ knowledge and perception of rational medicine use, in line with the study objectives. Chi-squared statistics and Fisher’s exact test were utilized to identify factors associated with good knowledge and perception among participants. Logistic regression was then employed to assess the strength of the associations, with odd ratios reported at a significant level of 0.05.

Results
Out of 192 participants, 85.4% held a positive view of rational medicine use, stressing patient safety and recognizing risks like antimicrobial resistance and polypharmacy. Perception was influenced by factors such as prescriber profession, access to references, and drug bulletin updates. Additionally, 65.6% demonstrated good knowledge of rational medicine use, which was notably influenced by factors like using standard prescribing guidelines, having a functional Drug and Therapeutics Committee, prescriber profession, and the frequency of drug bulletin updates.

Conclusion
The study emphasizes the critical need to address knowledge gaps among healthcare professionals, especially nurses and other prescribers, to ensure the safe and effective use of medications. It highlights the positive influence of utilizing preferred prescribing references and the existence of functional Drug and Therapeutics Committees in hospitals on knowledge levels. However, the unexpected findings regarding the limited impact of frequent updates of drug bulletins require further investigation.
Prevalence and risk factors of frailty in older adults with diabetes: A systematic review and meta-analysis
Authors: Liu Yaqing , Zhang Longhan , Li Xiaoyun , Luo An , Guo Sixuan , Liu Xun , Wei Xingyu , Sun Yuanhong , Wang Manyi , Liao Li 
Published: October 2024

Objective
This systematic review and meta-analysis aimed to evaluate the prevalence of frailty and pre-frailty in older adults with diabetes; and to identify the risk factors associated with frailty in this population.

Design
Systematic review and meta-analysis.

Participants
24,332 people aged 60 years and older with diabetes.

Methods
Six databases were searched (PubMed, Embase, the Cochrane Library, Web of Science, China Knowledge Resource Integrated Database, and Chinese Biomedical Database) up to 15 January 2024. Random effects models were used in instances of significant heterogeneity. Subgroup analysis and meta-regression were conducted to identify the potential source of heterogeneity. The Agency for Healthcare Research and Quality (AHRQ) and the Newcastle-Ottawa Scale (NOS) were applied to assess the quality of included studies.

Results
3,195 abstracts were screened, and 39 full-text studies were included. In 39 studies with 24,332 older people with diabetes, the pooled prevalence of frailty among older adults with diabetes was 30.0% (95% CI: 23.6%-36.7%). Among the twenty-one studies involving 7,922 older people with diabetes, the pooled prevalence of pre-frailty was 45.1% (95% CI: 38.5%-51.8%). The following risk factors were associated with frailty among older adults with diabetes: older age (OR = 1.08, 95% CI: 1.04–1.13, p<0.05), high HbA1c (OR = 2.14, 95% CI: 1.30–3.50, p<0.001), and less exercise (OR = 3.11, 95% CI: 1.36–7.12, p<0.001).

Conclusions
This suggests that clinical care providers should be vigilant in identifying frailty and risk factors of frailty while screening for and intervening in older adults with diabetes. However, there are not enough studies to identify comprehensive risk factors of frailty in older adults with diabetes.

Trial registration
PROSPERO registration number: CRD42023470933.
(−)-Epicatechin regulates endoplasmic reticulum stress and promotes ferroptosis in lung cancer cells via the PERK/eIF2α/ATF4 signaling pathway
Authors: Lv Zengbo , Liu Peiwan , Yang Yingyu , Ji Jianhua , Wu Anao , Huang Wensheng , Zhang Liqiong , Zhang Zhijun , Yang Yunkui , Li Wenhui , Huang Meifang 
Published: October 2024

Objective
(−)-Epicatechin (EC) is an active ingredient of Fagopyrum dibtrys (D. Don) Hara and can regulate lung cancer progression. However, the specific regulatory mechanism is poorly understood. This study explored the specific mechanism of EC in the treatment of lung cancer.

Methods
H460 cells were injected subcutaneously into the left dorsal sides of nude mice to establish an animal model of lung cancer. H460 and H1299 cells and nude mice were treated with different concentrations of EC. The expression levels of related proteins were detected by Western blotting. Cell proliferation, migration, and invasion were detected by CCK-8, colony formation, and Transwell assays. Flow cytometry was used to detect the Ca2+ level in lung cancer cells. Immunohistochemistry was used to detect the expression of Ki-67 in tumor tissues.

Results
This study revealed that ferroptosis in lung cancer cells was inhibited during lung cancer development. EC treatment promotes ferroptosis, inhibits the proliferation, migration and invasion of lung cancer cells, and inhibits the formation of tumors in vivo. Ferroptosis inhibitors (Fer-1) weaken the effects of EC on lung cancer cells, whereas a ferroptosis inducer (erastin) further promotes the effects of EC. In addition, endoplasmic reticulum (ER) stress is involved in the EC-induced ferroptosis of lung cancer cells, and treatment with GSK, an inhibitor of the ER stress protein PERK, can reverse the effect of EC.

Conclusion
EC therapy activates the PERK–eIF2α–ATF4 signaling pathway to increase ER stress, thereby promoting ferroptosis in lung cancer cells and inhibiting the occurrence and development of lung cancer. Our research suggests that EC may become a drug candidate for treating lung cancer.
Acceptability testing of the Carers-ID intervention to support the mental health of family carers of people with profound and multiple intellectual disabilities
Authors: Linden Mark , Truesdale Maria , Leonard Rachel Aine , Brown Michael , Marsh Lynne , Todd Stuart , Hughes N. , Forbes Trisha 
Published: October 2024

Background
Providing care and support for a person with intellectual disabilities can be challenging and may negatively impact on family carers’ health and wellbeing. A online support programme was co-designed with charitable organisations and family carers, to help meet the mental health and wellbeing needs of family carers.

Objective
To test the acceptability of a newly developed online support programme for carers of people with profound and multiple intellectual disabilities.

Methods
A sequential mixed-methods explanatory design was utilised. An adapted version of the Acceptability of Health Apps among Adolescents Scale was distributed to family carers across the United Kingdom and Ireland who had viewed the Carers-ID.com intervention. Participants were then invited to take part in an online interview. Qualitative and quantitative data were analysed separately and then brought together through the triangulation protocol.

Results
Seventy family carers (47 female, 23 male) responded to the acceptability survey, with 10 (7 female, 3 male) taking part in interviews. Carers expressed high levels of programme acceptability (mean = 75.43 out of 88). Six themes were generated from interviews with family carers; i) time is precious, ii) the breadth and depth of module content, iii) it was somebody’s experience; it was meaningful, iv) won’t work for everyone, v) representation: people I could identify with, and vi) module specific suggestions for future changes. Based on our triangulation, four areas of convergence were identified: programme usability and ease, attitudes towards the programme, perceptions of effectiveness, and programme relatability.

Conclusions
To be acceptable, online interventions for carers of people with intellectual disability need to be accessible, understandable and easy to use, as carers’ free time can be limited. It would be important to investigate the effectiveness of online interventions for family carers, specifically considering which carers the intervention works for, and for whom it may not.
Araceae Juss. used as an ornamental in Northeastern Brazil
Authors: Rodrigues Ana Cristina Alves , Andrade Ivanilza Moreira de , Costa Creusa Carvalho da , Santos Seliomar de Sousa Oliveira , Souza Ruanna  Thaimires Brandão 
Published: October 2024

Araceae Juss. is widely used by the local population for various purposes, including food, mysticism and crafts. The aim of this study was to conduct a survey of Araceae species used in neighborhoods in Floriano, Piauí, and to classify these species based on their origin and habit. The research employed the "Rapport" technique and semi-structured interviews with residents of the of Floriano, Piauí, along with an analysis of the species use value. Nineteen species belonging to thirteen genera were documented, categorized into two main uses: ornamental and mystical. Species such as Aglaonema commutatum Schott, Dieffenbachia seguine Schott, Epipremnum aureum (Linden & André) G.S.Bunting and Zamioculca zamiifolia (Lodd.)Engl. exhibited the highest use value (0.016 each). These species are predominantly cultivated and are of exotic origin, with varying habits including climbing, epiphytic, hemiepiphytic, and herbaceous. Caladium bicolor, Monstera obliqua and Philodendron acutatum are species native to Brazil, found in the Northeast region. However, only while Philodendron acutatum was recorded on the flora of the state. Studies like this contributes to the dissemination of local knowledge and facilitate the exploration of the Araceae flora. Further research is warranted to identify additional use categories and to catalog Araceae species specific to the state, given the limited availability of studies on this plant family in the region.
Granulomatous Colitis Due to Hermansky-Pudlak Syndrome
Authors: Koulali Hajar , Azzmouri Samira , Tajir Mariam , Zerrouki Khawla , Haloui Anass , Elmqaddem Ouiam , Zazour Abdelkrim , Ismaili Zahi , Kharrasse Ghizlane 
Published: October 2024

ABSTRACT
Hermansky-Pudlak syndrome (HPS) is a rare genetic disorder characterized by oculocutaneous albinism, bleeding diathesis, and multiorgan involvement. Granulomatous enterocolitis may occur in a subset of patients. Distinguishing HPS from other diseases such as Crohn's disease can be challenging, and managing HPS-associated colitis is complex. Recent reports suggest potential efficacy of infliximab in treating HPS-related granulomatous colitis. Here, we document the case of a 27-year-old patient with genetically confirmed HPS type 1, presenting with granulomatous colitis and successfully treated with corticosteroids and infliximab.
Computation and analysis of optimal disturbances of periodic solution of the hepatitis B dynamics model
Authors: Khristichenko Michael Yu. , Mironov Ilya V. , Nechepurenko Yuri M. , Grebennikov Dmitry S. , Bocharov Gennady A. 
Published: October 2024

Abstract
Optimal disturbances of the periodic solution of the hepatitis B dynamics model corresponding to the chronic recurrent form of the disease are found. The dependence of the optimal disturbance on the phase of periodic solution is analyzed. Four phases of the solution are considered, they correspond to clinically different periods of development of the immune response and severity of the disease, namely, activation of antiviral immune reactions, attenuation of reactions, peak and minimum viral load. The possibility of using optimal disturbances to exit the domain of attraction of the considered periodic solution using minimal impact is studied. The components of disturbances that may underlie the phenomenon of spontaneous recovery from chronic hepatitis B observed in clinical practice are identified.
Refining uniform approximation algorithm for low-rank Chebyshev embeddings
Authors: Morozov Stanislav , Zheltkov Dmitry , Osinsky Alexander 
Published: October 2024

Abstract
Nowadays, low-rank approximations are a critical component of many numerical procedures. Traditionally the problem of low-rank approximation of matrices is solved in unitary invariant norms such as Frobenius or spectral norm due to the existence of efficient methods for constructing approximations. However, recent results discover the potential of low-rank approximations in the Chebyshev norm, which naturally arises in many applications. In this paper, we investigate the problem of uniform approximation of vectors, which is the main component in the low-rank approximations of matrices in the Chebyshev norm. The principal novelty of this paper is the accelerated algorithm for solving uniform approximation problems. We also analyze the iterative procedure of the proposed algorithm and demonstrate that it has a geometric convergence rate. Finally, we provide an extensive numerical evaluation, which demonstrates the effectiveness of the proposed procedures.
Religionsmusikologie als Teildisziplin der Religionswissenschaft
Authors: Ragnitz Clara 
Published: October 2024

Zusammenfassung
‚Musik‘ ist ein elementarer, wenngleich wenig erforschter, Bestandteil religiöser Praxis. Daher wird in den aktuellen Stand der Religionsmusikologie als Teildisziplin der Religionswissenschaft sowie den neueren Forschungsstand eingeführt. Dieser wird anhand der zuvor aufgestellten Kriterien einer musikphilosophisch grundierten Arbeitsdefinition von Musik auf seine religionswissenschaftliche Haltbarkeit überprüft. Anhand der hierin festgestellten Desiderata sowie Monita wird daraufhin programmatisch entworfen, was die Religionsmusikologie für die Religionswissenschaft leisten kann. Hierfür wird die Bezugsdisziplin Musikwissenschaft sowie ihre relevanten Teildisziplinen inklusive der kulturwissenschaftlichen Atmosphärenforschung herangezogen, um einen Impuls für die religionswissenschaftliche Erforschung von Musik in religiöser Praxis zu liefern. Ausgehend von der Arbeitsdefinition von Musik als affektive Kommunikation, welche anhand etischer Termini intersubjektiv zugänglich gemacht und analysiert werden kann, wird dafür plädiert, einen diskursiven Ansatz zu wählen. Die intentionale Nutzung von Musik wird somit als klanglich-kommunikativer Aspekt religiöser Praxis anerkannt, dem – gemäß der Komplexität des Phänomens – mit einem breiten methodischen sowie theoretisch fundierten Instrumentarium begegnet werden muss, welches aus den musikwissenschaftlichen Bezugsdisziplinen geschöpft werden kann.
Embracing Complexity
Authors: Biano Ilaria W 
Published: October 2024

The aim of the article is to propose a posthumanist approach to the issue of (non/religious) identity. Reflections at the intersection between post-humanism, study of religion, and identities help to better understand and clarify how core elements of posthumanism such as the decentring and relativization of the Human and the Anthropos do not mean that human beings don’t matter at all, but they point out a specific, supposedly universal concept of Man. In this sense, central is an intersectional approach to identity and difference. While identity has always been constructed on dichotomies, Posthumanism, following previous forms of deconstruction, emphasizes the multiplicity of identities, their constructedness, and their constant multiple recombinations in innovative forms. An integrated posthumanist approach to the intersection of different aspects and components of identity, including non/religious ones, has the potential for highlighting both the idea that identity is not a monolithic concept, and the risks linked to a reification of something ultimately constructed—as it happens with identity politics, but also with its critics.
Strategic management accounting and strategic analysis as tools for ensuring the efficiency of business entities and their competitiveness
Authors: Купріна Наталія , Баранюк Христина 
Published: October 2024

The purpose of this study is the need to apply a system of effective tools for the economic transformation of subjects of the national economy in modern conditions in order to ensure their competitiveness and efficiency of functioning. The article proves and verifies the hypothesis about the need to use strategic analysis and strategic management accounting as necessary and justified tools for the persistent transformation of subjects of the national economy in the modern conditions of their management. The necessity of using the McKinsey method for strategic analysis of business entities at the macro- and meso-level has been proven. It has been substantiated that in order to ensure the assessment and control of the persistent transformation of business entities, it is necessary to apply strategic management accounting at all levels of their research.