bluuebunny/crossref_metadata_2025_split huggingface dataset:
Marketing communication in the digital age: online ads, online WOM and mobile game adoptions
Authors: Gong Shiyang , Wang Wanqin , Li Qian 
Published: July 2019

Purpose
This study aims to explore the interdependent impacts of online word-of-mouth (WOM) and online ads on digital product adoptions, as well as their dynamic changes throughout the product life cycle.

Design/methodology/approach
This study adopted an empirical approach by using a unique data set of five mobile games launched between 2012 and 2014 provided by Renren Games Ltd. in China.

Findings
The results indicated that advertising generally has a positive impact on WOM. During the product life cycle, the influence on volume and variance gradually decreases, whereas the impact on valence increases over time. WOM (including WOM volume and WOM valence) and advertising both have positive impacts on game adoptions. They complement each other to shape adoptions throughout the product life cycle: advertising is more effective in encouraging adoptions in the early and later stages of the demand evolution process, whereas WOM has a greater impact on adoptions in the mid-stage.

Practical implications
This study provided detailed managerial recommendations on how to effectively integrate different types of marketing communication and optimize the investment strategy of online ads and online WOM in different stages of the product life cycle.

Originality/value
First, the study enriched the theory of digital marketing communication by studying the relationship between mass media (online ads), interpersonal media (online WOM) and product adoptions in the network context. Second, it provided an empirical basis for the inference of the dynamic development of media effect in the new product diffusion theory. Third, the results will be helpful to end the debate in current theoretical literature on whether there is a complementary or alternative relationship between the two effects. Last but not least, it enriched research on the antecedents and dynamic effects of online WOM.
Effects of green coffee extract supplementation on level of chemerin, malondialdehyde, nutritional and metabolic status in patients with metabolic syndrome
Authors: Fasihi Mehdi , Yousefi Mohammad , Safaiyan Abdolrasoul , Mousavi Mele Mahdi , Rostami Mohammadreza , Barzegar Ali 
Published: July 2019

Purpose
The purpose of this paper is to examine the effect of green coffee extract on anthropometric index and lipid profile, fasting blood sugar, chemerin and malondialdehyde on subjects with metabolic syndrome.

Design/methodology/approach
A randomized, double-blind, placebo-controlled clinical trial was conducted in Sheikh Al Raise Clinic from September 2016 to March 2017. The participants were randomly divided into green coffee group and placebo group. Green coffee group (n = 24) received green coffee extract (GCE), while placebo group (n = 24) took cellulose as a placebo, two capsules (400 mg) two times each day for eight weeks. The anthropometric index and lipid profile, fasting blood sugar, chemerin and malondialdehyde were measured at the beginning of the study and after eight weeks of treatment with GCE. Blood samples were collected before and after eight weeks of supplementation.

Findings
Significant weight loss, from 84.80 ± 2.12 kg to 80.94 ± 2.10 kg (ptime = 0.030, pGC = 0.007), as well as decreases in body mass index (ptime = 0.034, pGC = 0.006) were detected in the green coffee group after eight weeks. Also, the green coffee group has significant lower (pgroup = 0.029, ptime = 0.013) malondialdehyde (MDA) compared to the placebo group, and there was a significant difference between two groups at the insulin level and homeostatic model assessment of insulin resistance (HOMA-IR) (ptime = 0.001, pgroup = 0.048), (ptime = 0.012, pgroup = 0.007). However, there was no significant difference in lipid profile, fasting blood sugar and serum chemerin between two groups after eight weeks of supplementation.

Originality/value
This paper showed the statistical difference in body weight, malondialdehyde, insulin and insulin resistance after eight weeks of treatment. GCE might be associated to reduction in the carbohydrate absorption and the enhancement of lipid metabolism.
Can hot temperatures limit disease transmission? A test of mechanisms in a zooplankton–fungus system
Authors: Shocket Marta S. , Magnante Alexandra , Duffy Meghan A. , Cáceres Carla E. , Hall Spencer R. 
Published: July 2019

Abstract

Thermal ecology theory predicts that transmission of infectious diseases should respond unimodally to temperature, that is be maximized at intermediate temperatures and constrained at extreme low and high temperatures. However, empirical evidence linking hot temperatures to decreased transmission in nature remains limited.

We tested the hypothesis that hot temperatures constrain transmission in a zooplankton–fungus (Daphnia dentifera–Metschnikowia bicuspidata) disease system where autumnal epidemics typically start after lakes cool from their peak summer temperatures. This pattern suggested that maximally hot summer temperatures could be inhibiting disease spread.

Using a series of laboratory experiments, we examined the effects of high temperatures on five mechanistic components of transmission. We found that (a) high temperatures increased exposure to parasites by speeding up foraging rate but (b) did not alter infection success post‐exposure. (c) High temperatures lowered parasite production (due to faster host death and an inferred delay in parasite growth). (d) Parasites made in hot conditions were less infectious to the next host (instilling a parasite ‘rearing’ or 'trans‐host' effect of temperature during the prior infection). (e) High temperatures in the free‐living stage also reduce parasite infectivity, either by killing or harming parasites.

We then assembled the five mechanisms into an index of disease spread. The resulting unimodal thermal response was most strongly driven by the rearing effect. Transmission peaked at intermediate hot temperatures (25–26°C) and then decreased at maximally hot temperatures (30–32°C). However, transmission at these maximally hot temperatures only trended slightly lower than the baseline control (20°C), which easily sustains epidemics in laboratory conditions and in nature. Overall, we conclude that while exposure to hot epilimnetic temperatures does somewhat constrain disease, we lack evidence that this effect fully explains the lack of summer epidemics in this natural system. This work demonstrates the importance of experimentally testing hypothesized mechanisms of thermal constraints on disease transmission. Furthermore, it cautions against drawing conclusions based on field patterns and theory alone.

A free Plain Language Summary can be found within the Supporting Information of this article.
Death by Ram Attack: A Case Report from Greece and a Brief Review of the Literature
Authors: Katsos Konstantinos D. , Sakelliadis Emmanouil I. , Moraitis Konstantinos , Spiliopoulou Chara A. 
Published: July 2019

AbstractA case of a ram attack that caused injuries to a 73‐year‐old man is presented. The deceased survived the attack and had the opportunity to speak with a friend over the phone before being transferred to the hospital. After a 21‐day hospitalization, the patient passed away. A postmortem examination was performed to ascertain the cause of death. The autopsy findings are presented along with a brief review of the literature. Attacks by agricultural animals (or livestock) around the world are reported in the scientific literature. Fatalities from ram attacks are extremely rare. The need to implement specific codes in the ICD system, relevant to each animal attack, appears to be of great importance, in order to allow tracking of animal‐related deaths.
Rho‐associated coiled‐coil kinase 1 activation mediates amyloid precursor protein site‐specific Ser655 phosphorylation and triggers amyloid pathology
Authors: Hu Yong‐Bo , Ren Ru‐Jing , Zhang Yong‐Fang , Huang Yue , Cui Hai‐Lun , Ma Chao , Qiu Wen‐Ying , Wang Hao , Cui Pei‐Jing , Chen Hong‐Zhuan , Wang Gang 
Published: July 2019

AbstractRho‐associated coiled‐coil kinase 1 (ROCK1) is proposed to be implicated in Aβ suppression; however, the role for ROCK1 in amyloidogenic metabolism of amyloid precursor protein (APP) to produce Aβ was unknown. In the present study, we showed that ROCK1 kinase activity and its APP binding were enhanced in AD brain, resulting in increased β‐secretase cleavage of APP. Furthermore, we firstly confirmed that APP served as a substrate for ROCK1 and its major phosphorylation site was located at Ser655. The increased level of APP Ser655 phosphorylation was observed in the brain of APP/PS1 mice and AD patients compared to controls. Moreover, blockade of APP Ser655 phosphorylation, or inhibition of ROCK1 activity with either shRNA knockdown or Y‐27632, ameliorated amyloid pathology and improved learning and memory in APP/PS1 mice. These findings suggest that activated ROCK1 targets APP Ser655 phosphorylation, which promotes amyloid processing and pathology. Inhibition of ROCK1 could be a potential therapeutic approach for AD.
The Emergence of Cognitive Maps for Spatial Navigation in 7‐ to 10‐Year‐Old Children
Authors: Burles Ford , Liu Irene , Hart Chelsie , Murias Kara , Graham Susan A. , Iaria Giuseppe 
Published: July 2019

Although much is known about adults’ ability to orient by means of cognitive maps (mental representations of the environment), it is less clear when this important ability emerges in development. In the present study, 97 seven‐ to 10‐year‐olds and 26 adults played a video game designed to investigate the ability to orient using cognitive maps. The game required participants to reach target locations as quickly as possible, necessitating the identification and use of novel shortcuts. Seven‐ and 8‐year‐olds were less effective than older children and adults in using shortcuts. These findings provide clear evidence of a distinct developmental change around 9 years of age when children begin to proficiently orient and navigate using cognitive maps.
Memento: Localized Time‐Warping for Spatio‐Temporal Selection
Authors: Solteszova V. , Smit N. N. , Stoppel S. , Grüner R. , Bruckner S. 
Published: July 2019

AbstractInteraction techniques for temporal data are often focused on affecting the spatial aspects of the data, for instance through the use of transfer functions, camera navigation or clipping planes. However, the temporal aspect of the data interaction is often neglected. The temporal component is either visualized as individual time steps, an animation or a static summary over the temporal domain. When dealing with streaming data, these techniques are unable to cope with the task of re‐viewing an interesting local spatio‐temporal event, while continuing to observe the rest of the feed. We propose a novel technique that allows users to interactively specify areas of interest in the spatio‐temporal domain. By employing a time‐warp function, we are able to slow down time, freeze time or even travel back in time, around spatio‐temporal events of interest. The combination of such a (pre‐defined) time‐warp function and brushing directly in the data to select regions of interest allows for a detailed review of temporally and spatially localized events, while maintaining an overview of the global spatio‐temporal data. We demonstrate the utility of our technique with several usage scenarios.
“If you don't speak from the heart, the young mob aren't going to listen at all”: An invitation for youth mental health services to engage in new ways of working
Authors: Wright Michael , Culbong Tiana , Crisp Nikayla , Biedermann Britta , Lin Ashleigh 
Published: July 2019

AbstractAimAboriginal and Torres Strait Islander young people are more likely to experience mental health issues or end their life by suicide than non‐Aboriginal youth, but are less likely to access mental health services for support. Systemic change is required if mainstream youth mental health services are to be relevant and culturally secure for Aboriginal and Torres Strait Islander young people.Methods
Building Bridges (2017‐2019) is a three‐year participatory action research project being conducted in partnership with the Nyoongar community and three mainstream youth mental health services in Perth, Western Australia. The project involves Nyoongar Elders and Aboriginal and Torres Strait Islander young people working directly with senior management and key staff of youth mental health services to co‐design, implement and evaluate a framework for systems change. The aim of the project is to increase Aboriginal and Torres Strait Islander young people's engagement with services and improve mental health outcomes for young people and their families.ResultsThis paper outlines the engagement process that underpinned the first phase of the project. Our research methods are premised by an investment in establishing safe spaces for the Elders, young people and service staff to engage in open, honest dialogue. We present two key activities that illustrate this process of building trust and deepening understanding, namely: spending time “On Country” and engaging in a “storying” process.Conclusions
Building Bridges demonstrates the centrality of trusting relationships for systemic change and the way in which meaningful engagement is at the core of both the process and the outcome.
In vitro interactions of abiraterone, erythromycin, and CYP3A4: implications for drug–drug interactions
Authors: Masamrekh Rami A. , Kuzikov Alexey V. , Haurychenka Yaraslau I. , Shcherbakov Kirill A. , Veselovsky Alexander V. , Filimonov Dmitrii A. , Dmitriev Alexander V. , Zavialova Maria G. , Gilep Andrei A. , Shkel Tatsiana V. , Strushkevich Natallia V. , Usanov Sergey A. , Archakov Alexander I. , Shumyantseva Victoria V. 
Published: July 2019

AbstractPotential drug–drug interactions of the antitumor drug abiraterone and the macrolide antibiotic erythromycin were studied at the stage of cytochrome P450 3A4 (CYP3A4) biotransformation. Using differential spectroscopy, we have shown that abiraterone is a type II ligand of CYP3A4. The dependence of CYP3A4 spectral changes on the concentration of abiraterone is sigmoidal, which indicates cooperative interactions of CYP3A4 with abiraterone; these interactions were confirmed by molecular docking. The dissociation constant (Kd) and Hill coefficient (h) values for the CYP3A4–abiraterone complex were calculated as 3.8 ± 0.1 μM and 2.3 ± 0.2, respectively. An electrochemical enzymatic system based on CYP3A4 immobilized on a screen‐printed electrode was used to show that abiraterone acts as a competitive inhibitor toward erythromycin N‐demethylase activity of CYP3A4 (apparent Ki = 8.1 ± 1.2 μM), while erythromycin and its products of enzymatic metabolism do not affect abiraterone N‐oxidation by CYP3A4. In conclusion, the inhibition properties of abiraterone toward CYP3A4‐dependent N‐demethylation of erythromycin and the biologically inert behavior of erythromycin toward abiraterone hydroxylation were demonstrated.
Real‐world experience of dupilumab treatment for atopic dermatitis in adults: a retrospective analysis of patients' records
Authors: Wang Candice , Kraus Christina N. , Patel Krupa G. , Ganesan Anand K. , Grando Sergei A. 
Published: July 2019

AbstractBackgroundClinical trial data for dupilumab, a monoclonal antibody against the interleukin‐4 receptor (IL‐4Rα), have shown that it is safe and effective for the treatment of moderate to severe atopic dermatitis in patients whose disease is resistant to other therapies. However, little real‐world experience with dupilumab use has been reported thus far. The aim of this retrospective study was to assess overall outcomes in adult patients with atopic dermatitis (AD) treated with dupilumab.MethodsA retrospective review of electronic medical records was conducted for patients treated with dupilumab in the Department of Dermatology at the University of California, Irvine.ResultsWe analyzed the medical records of 77 AD patients who received dupilumab according to standard dosing and had at least one documented follow‐up visit. In 66 patients (86%), dupilumab improved clinical disease severity, with 23 patients (30%) experiencing complete clearance on dupilumab. Dupilumab was generally well‐tolerated and caused no serious adverse events. The most common side effects included dry eyes, conjunctivitis, and keratitis. The most common reason for discontinuation of treatment was lack of substantial clinical improvement or progression of disease severity, followed by ophthalmologic side effects.ConclusionsOverall, dupilumab was well‐tolerated and resulted in clinical improvement in our patient population. These results provide additional important information on the safety and utility of dupilumab treatment for moderate to severe atopic dermatitis in the real‐world clinical setting.
Evaluation of pharmacy-based telephone interventions on medication pick-up rates: a retrospective, quality improvement study at charity outpatient clinics
Authors: Tatachar Amulya , Cole Lyndsay C , Nguyen Hoa L , Heinrich Krista 
Published: July 2019

Abstract

Objectives
To evaluate a live telephonic outreach intervention made by clinical pharmacists and clinical pharmacy technicians on medication pick-up rates.

Methods
A retrospective, quality improvement study conducted at six outpatient charity clinics in Dallas-Fort Worth area between 1 January 2017 and 31 July 2017. A live telephonic call was made by a pharmacy team member if the patient did not pick-up at least one prescription item. Patients may receive more than one call if they did not pick-up medication(s) more than once during the study period. A live telephonic call resulted in three categories: contacted, left a voice message and unable to contact. Medication pick-up rates were obtained from a pharmacy claims database.

Key findings
The study population included 1726 individual patients who failed to pick-up at least one medication from Baylor Scott & White Health pharmacy. A total of 2551 live telephonic calls were made for the study population. A total of 1175 live telephonic calls (46.1%, n = 2551) resulted in a patient picking up medication(s). Results from the generalized estimating equation logistic regression models showed that patients who received a voice message (OR: 1.37; 95% CI: 1.05 to 1.80; P &lt; 0.021) or was contacted (OR: 1.99; 95% CI: 1.54 to 2.60; P &lt; 0.001) were more likely to pick-up their medications as compared to the ‘unable to contact’ group.

Conclusions
Telephonic interventions from the pharmacy team can serve as a successful means to increase medication pick-up rates among charity clinic patients.
Effectiveness of cognitive behaviour therapy‐based multicomponent interventions on fear of falling among community‐dwelling older adults: A systematic review and meta‐analysis
Authors: Chua Claris Hui Min , Jiang Ying , Lim Der Shin , Wu Vivien Xi , Wang Wenru 
Published: July 2019

AbstractAimsTo systematically review the evidence and determine the effectiveness of cognitive behaviour therapy‐based multicomponent interventions on fear of falling and falls among community‐dwelling older adults who are at risk of falling.DesignA systematic review and meta‐analysis.Data SourcesSix electronic databases, including CENTRAL, CINAHL, EMBASE, PubMed, PsycInfo and Scopus, were searched. Studies published in English from January 1998–July 2018 were included in this review.Review MethodsOnly randomized controlled trials addressing fear of falling and/or the occurrence of falls using cognitive behaviour therapy‐based multicomponent interventions were included. A standard procedure based on the Cochrane Handbook for Systematic Reviews of Interventions was used to assess the risk of bias of the selected studies. A meta‐analysis was performed to determine the effectiveness of cognitive behaviour therapy‐based multicomponent interventions on fear of falling immediately after the interventions, at ≤6 months and >6 months postinterventions.ResultsThis review included 15 randomized controlled trials involving 3,165 community‐dwelling adults aged 60 years and older. The pooled results showed that the intervention effects, including immediate, short‐term (i.e., ≤6 months postintervention) and long‐term (i.e., >6 months postintervention) effects, favoured the intervention group.ConclusionCognitive behaviour therapy‐based multicomponent interventions are effective at reducing fear of falling among community‐dwelling older adults who are at risk of falling.ImpactFear of falling has been implicated in activity restriction among older adults and fall prevention interventions need to be multifaceted. Understanding and attending to individual psychological needs are as important as exercise training.
The experience of adults with sickle cell disease and their HLA‐matched adult sibling donors after allogeneic hematopoietic stem cell transplantation
Authors: Gallo Agatha M. , Patil Crystal L. , Knafl Kathleen A. , Angst Denise A. , Rondelli Damiano , Saraf Santosh L. 
Published: July 2019

AbstractAimTo provide a rich description and in‐depth understanding of the recipient–donor allogeneic hematopoietic stem cell transplantation experience.BackgroundA stem cell transplant has a high likelihood of improving symptoms of sickle cell disease in adults. While studies have reported the transplant experiences of recipients and donors with haematological malignancies, no published reports have examined the experience of both adult recipients with sickle cell disease and their donors.DesignExploratory qualitative descriptive analysis.MethodsWe conducted individual interviews with 13 recipients and donors (eight males, five females) representing five recipient–donor dyads and one recipient–donor triad from one Midwest transplant centre between August 2017–February 2018. Interviews were digitally audio‐recorded, transcribed verbatim and analysed using conventional content analysis.FindingsFive themes were identified: the downward spiral and a second chance; getting the monster off my back; difficult and manageable; it was worth it; and relating to the healthcare team.ConclusionsThe results provide a description and insights into the complex nature of the stem cell transplant experience in sickle cell disease from the perspectives of both recipients and donors.ImpactHealth provider awareness of recipient–donor experiences can contribute to family‐centred care that supports the health and quality of life for both recipients and donors. This understanding promotes high quality clinical care and improved communications by taking into account the knowledge, values and informed preferences of recipients and donors and contributes to improved decision‐making and clinical care. Future research can assess family experiences that support informed choice for potential transplant candidates.