bluuebunny/crossref_metadata_2025_split huggingface dataset:
Estimation of Radio Attenuation Constants for Underground Mine Communication Systems Using Radio Wave Propagation Simulation
Authors: Sato Naru , Shionoiri Takaya , Ikeda Hajime , Toriya Hisatoshi , Adachi Tsuyoshi , Kawamura Youhei 
Published: November 2024

Abstract

This study aims to validate the estimation of radio wave attenuation constants in underground mine communication systems using propagation simulation. Unlike open-pit mines, underground mines necessitate stringent safety measures to protect workers in the event of mechanical failures or rock falls. Early detection and warnings of potential hazards are crucial for safety, prompting the implementation of monitoring systems. Wireless communication is increasingly favored for its ability to simplify the complex installation of these systems in underground environments. However, designing an effective communication system must account for factors such as radio wave attenuation and the influence of physical obstacles. Simulations can estimate the required number and locations of wireless communication devices, aiding in system design. In this study, RSSI (Received Signal Strength Indicator) values at the Osarizawa mine were calculated using Wireless InSite software and were compared to measured values, showing an error of 4.41 dB. The radio wave attenuation constant was determined to be 4.90 ×10− 2 dB/m.
Intravenous Iron as an Alternative to Blood Transfusion in Cancer Patients: A Single Center Experience
Authors: Yeung Ian , Chan Adrian Wai , Tin Winnie Wing Yan , Yip Sze Fai , Wong Frank Chi Sing 
Published: November 2024

Abstract

Purpose
Intravenous (IV) iron is well-documented for treating chemotherapy-induced anemia, but data on its efficacy in a wider oncological setting are limited. Our study provides real-world experience with IV iron in both patients on active treatment and those under supportive care.
Methods
This retrospective study analyzed the effectiveness and safety of IV iron in cancer patients at an integrated oncology center in Hong Kong from January 2019 to August 2023. Patients who received IV iron were evaluated for changes in hemoglobin (Hb) and transfusion requirements.
Results
The effectiveness population comprised 283 eligible episodes, with mean Hb rising from 7.6 g/dL at baseline to 8.8 g/dL by day 28 and 9.3 g/dL by day 60 (p < 0.001). The mean units of packed cells transfused per patient declined by 55% up to 12 weeks following IV iron (p = 0.01). Notably, 164 (58%) patients were receiving supportive care, showing an Hb rise from 7.3 g/dL to 8.3 g/dL on day 28 (p < 0.001) and a 62% reduction in transfusions (p = 0.04). Baseline Hb, treatment intent and iron deficiency group significantly predicted Hb changes on day 28 in multiple linear regression.
Conclusion
To our knowledge, our study presents the largest dataset reported on IV iron use in cancer patients receiving supportive care. IV iron induces a meaningful Hb rise in both patients on active treatment and patients under supportive care, providing a safe alternative to blood transfusion.
An Artificial Intelligence Technique: Experimental Analysis of Population-based Physarum-Energy Optimization Algorithm
Authors: DEMIRAL Mehmet Fatih 
Published: November 2024

Abstract

The traveling salesman problem (TSP) is an NP-hard problem being studied by many researchers. Metaheuristic algorithms generally depend on nature-inspired phenomena successfully applied to combinatorial optimization, such as routing, scheduling, assignment problems, engineering, optimization, genetics, robotics, nanotechnology, and various fields. In this paper, new versions of physarum-energy optimization algorithms (PEOs) which are population-based optimization algorithms were applied to the symmetric traveling salesman problems. PEOs use multiple solutions (population), multiple conductivities (dij) for the stochastic disturbance model, and appropriate parameter strategies to update the solutions in each generation. To measure the effectiveness of the PEOs and the hybrids, the algorithms have been evaluated on several benchmark problems and compared to the recent metaheuristics. The computational results show that the PEOs and their hybrids (k-NN, 2-opt, 3-opt, k-opt) can find high-quality results compared to the original physarum-energy optimization algorithm (PEO), ant colony optimization (ACO), black hole algorithm (BH), tabu search, and other hybrid algorithms such as whale optimization algorithm + 4-opt heuristic (WOA + 4-opt), camel algorithm + 4-opt heuristic (CA + 4-opt), genetic algorithm + 2-opt heuristic (GA + 2-opt), and the k-NN, 2-opt, 3-opt, k-opt algorithms. Moreover, the population-based PEOs and their derived forms solve the optimization problem quite competitively in CPU time as compared to other test algorithms.
Prevalence and associated factors of otitis media among children with ear compliant attending at some selected hospitals in Mogadishu, Somalia.
Authors: Khaliif HALIMA Abdirahman , Abdihakim Zeynab Ahmed , Hussien Mohamed , Hassan Jamal , Hassan Mulki Mukhtar , Hussien Abdi wali Mohamed , Saney Mohamed Abdi 
Published: November 2024

Abstract

Background
Otitis media (OM), an inflammation of the middle ear, is one of the most common pediatric illnesses, affecting children worldwide. Despite advances in healthcare, OM continues to be a significant cause of morbidity, with recurrent cases contributing to hearing impairment and developmental delays.
Methods
A cross-sectional analysis was conducted, involving 384 participants from some selected hospitals in Benadir region. Data on the occurrence of otitis media were collected through clinical diagnoses, patient history, and caregiver. Potential risk factors and underlying health conditions, were examined using multivariate logistic regression models.
Results
The prevalence of otitis media was found to be 32.8% among the participants. Several significant risk factors for OM were identified, including Gender (OR = 1.80, 95% CI: 1.20–2.70; p = 0.005), age (OR = 2.0, 95% CI: 1.15–3.48; p = 0.015), a exposure to smoke (OR = 3.0, 95% CI: 1.50–5.99; p = 0.002), daycare attendance (OR = 2.05, 95% CI: 1.35–3.12; p = 0.001), and lower socio-economic status (OR = 3.0, 95% CI: 1.22–7.35; p = 0.016). A Parental employment and the history of allergies were also linked to an increased risk of OM.
Conclusion
Otitis media remains highly prevalent among children, with multiple risk factors contributing to its prevalence. Public health initiatives should focus on reducing known environmental risks, improving early diagnostic measures, and promoting education on the prevention of OM, particularly in high-risk populations.
Comparative proteome and phosphoproteome analyses reveal importance of phosphorylation of kinases/phosphatases during tea winter dormancy
Authors: Liu Guofeng , Han Yanting , Li Jintao , Yuan Hongyu 
Published: November 2024

Abstract

Winter dormancy is important for tea plants to survive from strict environmental conditions and its economic value in next spring. However, the molecular mechanisms of the translational and posttranslational regulation, especially phosphorylation has not been well understood. In the current study, lab-free proteome and Fe-NTA phosphopeptides enrichment-based lab-free phosphoproteome analyses were employed using the 4-time point ‘Xinyang No.10’ tea buds collected from late autumn to prior to bud sprouting in the early spring. A total of 4,599 proteins and 4,768 phosphopeptides corresponding to 2,581 phosphoproteins were obtained. Among which, 850 differentially expressed proteins (DEPs) and 775 differentially expressed phosphopeptides (fold change > 2, p < 0.05) were screened. Hierarchical clustering showed different results when DEPs and differentially expressed phosphopeptides were used. DEPs were shown to be less enriched compared to differentially expressed phosphoproteins through MapMan classification analysis. DEPs were mainly enriched in substance metabolism and stress responsive events, while differentially expressed phosphoproteins were enriched in ‘RNA’, ‘signalling’, ‘development’ and ‘transport’. These results indicated that protein activity was more important than protein abundance during winter dormancy. Totally 45 kinases/phosphatases were found differentially phosphorylated, including KIN10, SnRK2, MPK6, CTR1 and PP2Cs, indicating the important roles of both kinases/phosphatases and the hormone signaling pathways, especially ABA and ethylene. Phosphorylation of sugar metabolism and plant-pathogen interaction related proteins suggesting the involvement of sugar and plant-pathogen interaction in tea winter dormancy. This study highlighted the important roles of phosphorylation regulation of ‘Xinyang No.10’ tea winter dormancy as well as the phosphorylation of kinases/phosphatases themselves.
Depressive disorder; clinical correlates and Tumor Necrosis Factor alpha among post COVID-19 patients
Authors: Sakr Aya Mohamed Khaled , Okasha Tarek Ahmed , El-Meguid Marwa Abd , Sayed Maha Mohamed , Mohamed Mariam Yehia 
Published: November 2024

Abstract

Background
COVID-19 infection is known to trigger a significant inflammatory response in the body. This response, characterized by elevated levels of cytokines including TNF-α that has proven to play a pivotal role in the severity and long-term effects of the disease. Paucity of the regional studies exploring the interplay between clinical and biochemical markers of post COVID-19 depression; creates a strong motive to shed light on this relationship in depth. Here, we estimated the rate of post-COVID depression, explored the clinical correlates of post-COVID depression, and examined the serum Tumor Necrosis factor alfa (TNF-α).
Methods
A group of 197 patients with post COVID-19 infection were randomly recruited and screened using general health questionnaire (GHQ). Then, SCID-I and Beck depression inventory were applied to confirm the diagnosis and assess the severity of major depressive disorder (MDD). Serum Tumor Necrosis factor alfa (TNF–α) was measured in depressed and non-depressed post COVID-19 patients.
Results
The rate of post-COVID depression was 27.8%; predominately, mild MDD (47.6%), followed by moderate MDD (38.1%) then, severe MDD (14.3%). There was a statistically significant difference between cases and control group regarding severity of COVID-19 (p = 0.001), number of vaccine doses received (p = 0.043), and TNF-alpha (p < 0.001). There was a statistically significant difference between severity of depression and both severity of COVID-19 infection (p = 0.003) and TNF-alpha (p < 0.001). Using regression analysis; TNF-α was the only predictive factor to post-COVID-19 depression (OR = 1.030, p < 0.001).
Conclusion
Our results suggest a strong link between serum TNF-alpha level and post-COVID depression, highlighting its pivotal role in refining the management outcome.
Damage-associated Molecular Patterns Related Score (DAMPscore) Identifies Subtypes of Hepatocellular Carcinoma with Distinct Prognosis and Treatment Sensitivity
Authors: Zhang Zhen , Jiang Yan , Hu Xuanyan , Tan Juan , Ma Yechen , Song Zewen , Fan Zhiwen , Liu Yang 
Published: November 2024

Abstract

Background: Damage-associated molecular patterns (DAMP) are pivotal for the incidence of Immunogenic cell death (ICD). In this work, we aimed to develop a DAMP related subtyping system in hepatocellular carcinoma (HCC) and identify hub genes regulating ICD in the disease.
Methods: A set of machine learning methods including consensus clustering, least absolute shrinkage and selection operator (LASSO) logistic regression model, and stepwise regression model, and other bioinformatics analytic tools were integrated to construct an DAMP-related risk score (DAMPscore). CIBERSORT and ESTIMATE algorithm were used to evaluate the immune cell infiltration in HCC. The prognostic capability of DAMPscore was evaluated and compared with clinical features and previously published mRNA signatures. The hub genes of DAMPscore were identified by weighted correlation network analysis (WGCNA). Immunohistochemistry (IHC) staining and in vitro experiments, including cell counting kit-8 assay and cell scratch test, were used to explore the role of the hub genes in HCC.
Results: HCC patients could be classified into two subgroups based on DAMP related genes. HCC patients with low DAMPscore had longer overall survival and were marked with high infiltration of immune cells, particularly CD8 T cells. DAMPscore could predict prognosis and immunotherapy response in HCC cohorts, and it exhibited superior predictability than clinical features and 53 previously published mRNA signatures. Thyroid hormone receptor interactor 13 (TRIP13), a hub gene of DAMPscore related genes, was significantly upregulated in HCC and could promote proliferation and migration of HCC cells. And silencing the expression of TRIP13 in HCC cells could increase sensitivity to 5-Fluorouracil (5-FU), a proved ICD-inducer in HCC
Conclusion: In conclusion, a stable and powerful DAMP-related signature was constructed and validated in HCC for prognosis and immunotherapy efficiency prediction. TRIP13 functioned as an oncogene in HCC and regulated sensitivity.
Percutaneous Endobiliary Ablation (RFA and MWA) Prior to Stenting: Assessing Feasibility and Outcomes in Malignant Biliary Obstruction.
Authors: Demirci Mahmut , Arslan Muhammet , Aslan Halil Serdar , Alver Kadir Han , Vurğun Sercan 
Published: November 2024

Abstract

Purpose: This study aims to evaluate the feasibility and effectiveness of percutaneous endobiliary Microwave Ablation (MWA) and Radiofrequency Ablation (RFA) prior to metallic stent placement for managing symptomatic, unresectable malignant biliary obstructions (MBOs).
Materials and Methods: We conducted a retrospective cohort analysis of 122 patients diagnosed with malignant tumors causing biliary obstructions, comparing outcomes between those receiving stents only and those undergoing prior ablation. Data collected included patient demographics, procedural details, complication rates, stent patency, and overall survival.
Results: Among the 122 patients, 101 received stents alone, while 21 underwent ablation (13 with MWA and 8 with RFA). There was no significant difference in stent patency duration (255.7 days for ablation vs. 219.6 days for stent-only, p=0.218) or overall survival (average of 123 days, p=0.105). The complication rate was significantly higher in the ablation group (p=0.023).
Conclusion:While endobiliary ablative treatments before metallic stenting appear feasible for palliative care of unresectable MBOs, our findings indicate no significant improvement in stent patency or overall survival. Further randomized controlled studies are necessary to clarify the efficacy and necessity of these techniques.
Astrocytomas IDH-mutant of Posterior Cranial Fossa, Clinical Presentation, Imaging Features and Onco-Functional Balance in Surgical Management
Authors: De Simone Matteo , Choucha Anis , Ranalli Carlotta , Pecoraro Giuseppina , Appay Romain , Chinot Oliver L. , Dufour Henry , Iaconetta Giorgio 
Published: November 2024

Abstract

Background
IDH-mutant astrocytomas (AIDHmut) in the posterior cranial fossa (PCF) are rare and present substantial diagnostic and therapeutic challenges due to their location.
Methods
We analyzed patients with PCF AIDHmut from our institution, treated between December 2021 and September 2024. Additionally, we conducted a systematic literature review (from January 2021 to September 2024) using PubMed, Ovid MEDLINE, and Ovid EMBASE to identify cases of PCF AIDHmut.
Results
We identified a total of 19 cases, including one institutional case. Most patients were young adults, with a male predominance (15 males, 4 females). Tumors primarily originated from the brainstem (94.7%), with only one case involving the cerebellum. Clinical presentations frequently included cranial nerve deficits, with diplopia being the most common symptom (47.4%). Adjuvant radiotherapy (IMRT, DT 54 Gy/27 fractions, 78.9%) and chemotherapy (temozolomide, 68.4%) formed the mainstays of treatment. Tumor grading revealed 63.2% (12/19) were WHO grade 2, 21% (4/19) were WHO grade 3, and 15.8% (3/19) were grade 4. The mean follow-up period was 45 months.
Conclusion
PCF AIDHmut are rare but pose significant treatment challenges due to their location and infiltrative nature. Multimodal treatment—comprising surgery, radiotherapy, and chemotherapy—is essential for achieving long-term disease control. Subtotal resection followed by adjuvant therapies provides a favorable balance between tumor control and functional preservation.
Target weight at discharge for children receiving their first inpatient treatment for an eating disorder
Authors: Kurata Kazumi , Inagawa Yuta , Yagihashi Tatsuhiko , Nakamura Takahiro , Obi Seiji , Suda Shiro 
Published: November 2024

Abstract

Purpose
There is no consensus regarding the optimal target weight for discharge during the hospitalization of children with eating disorders (EDs). We attempted to identify the ideal discharge weight for children receiving their first inpatient treatment for anorexia nervosa (AN) or avoidant/restrictive food intake disorder (ARFID).
Patients and Methods:
Sixty children (mean age: 12.8 yrs) diagnosed with AN or ARFID were followed for 1 year after discharge from a psychiatric ward. We analyzed the percent of ideal body weight (%IBW) at discharge, along with physical and social factors, to predict weight outcomes and rehospitalization risk. Longitudinal weight trends were assessed and Cox proportional hazards modeling was used to analyze the time to rehospitalization.
Results
Single and multiple regression analyses identified the %IBW at discharge as the sole significant predictor of %IBW at 1 year. A receiver operating characteristic curve determined that 86.4%IBW at discharge optimally predicted achieving 90%IBW by 1 year post-discharge. Patients who had achieved ≥ 86.4%IBW at discharge exhibited superior weight trajectories versus those discharged at < 86.4%IBW. A higher discharge %IBW was associated with prolonged time to rehospitalization, indicating a reduced risk of readmission.
Conclusions
Discharging pediatric patients at a higher weight is associated with improved weight recovery and a reduced risk of rehospitalization. A target discharge weight of 86.4%IBW may serve as an effective criterion for children with EDs.
Level of evidence:
Level Ⅲ, case-control analytic studies
Exploring the Potential Association Between Frozen Shoulder and Gastroesophageal Reflux Disease Using Mendelian Randomisation
Authors: Luo Bin , Huang Zongyuan , Zhang Shuai , Chen Yanting , Cao Mingde , Chen RuiZe , Kong Ling , Wu Xin , Guo Qianshi , Ouyang Yuxiang , Wang Hua , Song Yancheng 
Published: November 2024

Abstract

Background: Frozen shoulder (FS) has been suggested as a potential risk factor for gastroesophageal reflux disease (GERD). However, observational studies are limited in their ability to establish a causal relationship between FS and GERD.
Methods: This study aimed to investigate the genetic causal association between FS and GERD using a two-sample Mendelian randomization (MR) approach. Genome-wide association study (GWAS) summary data for FS were obtained from the UK Biobank, while GWAS summary data for GERD were sourced from the FinnGen Consortium. Multiple MR methods, including inverse-variance weighted (IVW), MR Egger, weighted median, simple mode, and weighted mode, were applied to estimate the causal effect. To assess heterogeneity, Cochrane's Q test was performed. Horizontal pleiotropy was evaluated using the MR-Egger intercept test and MR pleiotropy residual sum and outliers (MR-PRESSO) test. Sensitivity analyses, including leave-one-out analysis, were conducted to ensure the robustness of the findings.
Results: The IVW method indicated a potential causal relationship between FS and GERD (P = 0.018). There was no evidence of horizontal pleiotropy (P > 0.05), and heterogeneity among genetic variants was not significant (P > 0.05). Furthermore, leave-one-out analysis demonstrated that the association was consistent and reliable. Limitations: All participants included in the GWAS data were of European ancestry, which may limit the generalizability of the results. Additionally, due to data constraints, stratified analyses based on different populations, ethnicities, or age groups were not performed.
Conclusion: This two-sample MR analysis provides evidence of a genetic causal association between FS and GERD, highlighting the need for further research to explore this relationship in diverse populations.
Clinical efficacy evaluation of continuous renal replacement therapy in neonates with multiple organ dysfunction syndrome: a two-centered retrospective study
Authors: Chu Xiaoyun , Xu Jinglin , Sun Yifan , Gong Xiaohui , Chen Dongmei , Cai Cheng 
Published: November 2024

Abstract

Purpose: To investigate the effectiveness and safety of continuous renal replacement therapies (CRRT) for the treatment of neonatal multiple organ dysfunction syndrome (MODS).
Methods: We retrospectively analyzed clinical data of 60 neonateswith MODS treated with CRRT in the neonatal intensive care unit (NICU) at two tertiary hospitals from
January 2015 to May 2022. Hemodynamic parameters, liver and renal function, electrolytes, acid-base balance and routine blood indicators were recorded before CRRT, 12, 24h after CRRT initiation, and at the end of CRRT, respectively.
Results: (1) A total of 60 MODS neonates were included, of which gestational age was 38.7 (37.0, 39.8) weeks, birth weight was 3125.0 (2737.5, 3457.5) g, number of organs involved was 5.0 (4.0, 6.0). (2)Compared to pre-CRRT, the mean arterial pressure (MAP), blood lactate, urine output, serum creatinine, serum urea nitrogen, serum calcium, serum potassium, and leukocyte count were significantly improved at 12 h of CRRT. pH increased significantly at 24 h of CRRT, and the vasoactive inotropic score (VIS) decreased significantly at the end of CRRT. Complications of CRRT included platelet depression (58.3%), bleeding or thrombosis (18.3%), hypotension (18.3%), electrolyte disturbances (18.3%), and line blockage (16.7%). In total, 37 out of 60 neonates survived during hospitalization, with an overall survival rate of 61.7%.
Conclusions: Mortality in critically ill neonates with MODS requiring CRRT remains high. CRRT may be a safe and effective adjunctive therapy for critically ill neonates with MODS.