bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prediction of Surgical Outcome After Trabeculectomy for Neovascular Glaucoma With Anterior-segment Optical Coherence Tomography
Authors: Kokubun Taiki , Tsuda Satoru , Kunikata Hiroshi , Himori Noriko , Yokoyama Yu , Omodaka Kazuko , Kunimatsu-Sanuki Shiho , Nakazawa Toru 
Published: September 2018

Purpose:
To determine the potential of anterior-segment optical coherence tomography (AS-OCT) to predict posttrabeculectomy outcomes in neovascular glaucoma (NVG).

Patients and Methods:
We recruited 45 eyes of 40 NVG patients who underwent trabeculectomy. The patients were divided into success and failure groups based on the posttrabeculectomy outcome after 12 months. AS-OCT findings were compared in the success and failure groups at 1 and 2 weeks and 1, 3, 6, and 12 months. We also analyzed early posttrabeculectomy bleb parameters with multiple logistic regression, stepwise multiple regression, and the receiver operating characteristic curve to evaluate the power of these parameters to predict long-term outcomes.

Results:
Intraocular pressure at 6 and 12 months was lower in the success group than the failure group (P<0.0016=0.0048). Reflectivity of the bleb wall was higher in the failure group than the success group throughout the study (all: P<0.0016). Age and reflectivity of the bleb wall at 1 week were risk factors for failure with odds ratios for failure of 0.91 and 1.67. The area under the receiver operating characteristic curve for reflectivity of the bleb wall at 1 week was 0.943 with the cutoff set at 128.9 (sensitivity: 85.7%; specificity: 100.0%). Stepwise multiple regression analysis showed that reflectivity of the bleb wall at 1 week independently indicated the bleb survival period (β=−0.84; P<0.001).

Conclusions:
AS-OCT-measured reflectivity of the bleb wall, measured at 1 week of trabeculectomy for NVG, might be able to predict of the final status of the bleb.
The Effects of Tryptophan Enhancement and Depletion on Plasma Catecholamine Levels in Healthy Individuals
Authors: Boyle Stephen H. , Brummett Beverly H. , Kuhn Cynthia M. , Barefoot John C. , Siegler Ilene C. , Williams Redford B. , Georgiades Anastasia 
Published: September 2018

ABSTRACTObjectiveCentral nervous system (CNS) serotonin (5-HT) exerts both excitatory and inhibitory effects on the sympathetic nervous system (SNS) in animals. In this study, we examine the effects of tryptophan enhancement and depletion on plasma catecholamine levels in humans.MethodsThe total sample consisted of 164 healthy men and women who were tested for 2 days. Seventy-nine participants were randomized to a tryptophan enhancement condition and 85 to a tryptophan depletion condition. Both protocols consisted of a “sham day,” followed by an “active day.” Blood samples for assessment of plasma norepinephrine and epinephrine levels were collected before and after tryptophan enhancement/depletion. Data were analyzed using general linear models. Separate analyses were conducted for each study arm and for each measure.ResultsIn the depletion condition, both epinephrine (F(5,330) = 2.69,p= .021) and norepinephrine (F(5,335) = 2.79,p= .018) showed small increases on active versus “sham” depletion days. There were also significant day by time interactions for epinephrine (F(3,171) = 39.32,p< .0001) and norepinephrine (F(3,195) = 31.09,p< .0001) levels in the enhancement arm. Tryptophan infusion resulted in a marked increase in epinephrine (Premean= 23.92 (12.23) versus Postmean= 81.57 (62.36)) and decrease in norepinephrine (Premean= 257.2 (106.11) versus Postmean= 177.04 (87.15)), whereas levels of both catecholamines were stable on the “sham day.”ConclusionsCNS 5-HT exerts both inhibitory and excitatory effects on SNS activity in humans, potentially due to stimulation of CNS 5-HT receptors that have shown to have inhibitory (5-HT1A) and excitatory (5-HT1Aand/or 5-HT2) SNS effects in animal models.
Pulse Pressure and Outcome in Kidney Transplantation: Results From the Collaborative Transplant Study
Authors: Krüger Bernd , Döhler Bernd , Opelz Gerhard , Krämer Bernhard K. , Süsal Caner 
Published: September 2018

Background.
Systolic blood pressure (SBP) and diastolic blood pressure (DBP) are important predictors of graft and patient survival in renal transplantation. Pulse pressure (PP), the difference between systolic and diastolic pressure, has been associated with cardiovascular and renal morbidity in nontransplant epidemiological studies and clinical trials.

Methods.
In this large retrospective analysis of prospectively collected data, transplant recipients from 1995 to 2015 were examined for patient and death-censored graft survival.

Results.
In 43 006 recipients, a higher 1-year PP was significantly associated with inferior 10-year patient and death-censored graft survival. In patients 60 years or older, SBP but not DBP was associated with 10-year survival, an effect that was pronounced in patients with a normal SBP of <140 mm Hg and an increased PP of 60 mm Hg or greater, highlighting the superior impact of PP on survival in elderly recipients. In recipients 60 years or older, higher PP was associated with increased mortality due to circulatory system diseases but not to infection or cancer. The combination of PP 60 mm Hg or greater and high SBP of 140 mm Hg or greater showed the strongest association with death-censored graft survival across all age groups.

Conclusions.
We found convincing evidence that PP 1-year posttransplant is predictive of patient survival, especially in elderly recipients with normal SBP. Combined analysis of SBP and PP showed that high PP confers additional predictive information for patient survival beyond that derived from analysis of SBP alone. With regard to prediction of death-censored graft survival, the combination of high SBP and high PP showed the best correlation across all age groups.
Changes in Peristomal Skin Condition and User Experience of a Novel Ostomy Barrier Ring With Assisted Flow
Authors: Hunt Rhona , Kelleher Kevin , Coffey J. Calvin , Clarke Moloney Mary , Ahern Mary , Conway Elaine , Hannigan Ailish , Erwin-Toth Paula , O'Sullivan Leonard W. 
Published: September 2018

PURPOSE:
This purpose of this study was to evaluate a novel barrier ring with an assisted flow mechanism by assessing changes in peristomal moisture-associated skin damage (MASD) and perceptions of comfort, security, handling, and discretion in persons with an ileostomy for 6 months or longer.

DESIGN:
Single-arm, open-labeled feasibility study.

SUBJECTS AND SETTINGS:
Twenty participants (aged ≥18 years) with an ileostomy for 6 months or more participated in the study and 12 completed data collection. The primary reason for dropouts concerned compatibility issues with the barrier ring when used with certain convex pouching systems.

METHODS:
Participants used the barrier ring along with their normal ostomy pouching system for a period of 6 weeks. Changes in skin condition were assessed using the Ostomy Skin Tool (OST). Participants' perception of the barrier rings' comfort, security, handling, and discretion were also recorded on a 10-point scale, where participants would offer a low score if their experience was negative and a higher score if their experience was positive. Participants changed pouches and barrier rings at their own discretion. For participants who completed the study, the average skin condition and median ratings of comfort, security, handling, and discretion at 6 weeks were compared to baseline values.

RESULTS:
Twelve of the 20 participants (60%) completed the study. For those who completed, the mean score on the OST decreased from 6.2 ± 1.90 (mean ± SD) at baseline to 3.4 ±1.73 at 6 weeks, indicating a mean reduction of 2.8 (95% CI, −1.6 to −3.9; P < .001). The peristomal skin condition of 9 participants improved, whereas 3 experienced no change. All participants who completed the study rated comfort, handling, security, and discretion highly (median score 10 at baseline and at 6 weeks).

CONCLUSIONS:
Study findings indicate the novel ostomy barrier ring may reduce levels of peristomal MASD in persons living with an ileostomy, though a more extensive trial with a control group is recommended.
Prospective randomized controlled study directly comparing tadalafil and tamsulosin for male patients with lower urinary tract symptoms
Authors: Takeuchi Takumi , Toyokawa Satoshi , Okuno Yumiko , Ishida Noriko , Yamagoe Masanari , Zaitsu Masayoshi , Mikami Koji 
Published: September 2018

AbstractLower urinary tract symptoms are widespread in elderly men and often suggestive of benign prostatic hyperplasia (LUTS/BPH). A randomized, prospective, and open-labeled trial directly comparing the effects of tadalafil (a phosphodiesterase 5 inhibitor) 5 mg once daily and tamsulosin (an α1-blocker) 0.2 mg once daily for 12 weeks in LUTS/BPH patients was conducted. Data were recorded before randomization as well as at 4, 8, and 12 weeks after medication. Fifteen patients allocated tadalafil and 20 allocated tamsulosin completed 12 weeks of medication. Total IPSS, IPSS voiding, and IPSS-QOL scores declined with medication, but there was no difference between drugs. IPSS storage scores reduced more in the tamsulosin group than tadalafil group. OABSS did not decline significantly with medication. IIEF5 was maintained in the tadalafil group, but declined in the tamsulosin group. The maximum flow rate and post-void residual urine volume did not significantly change with medication. Daytime, night-time, and 24-hour urinary frequencies as well as the mean and largest daytime, night-time, and 24-hour voiding volumes per void did not significantly change with medication. In conclusion, tamsulosin was more effective to reduce storage symptoms than tadalafil. Tadalafil had the advantage of maintaining the erectile function.
Moderating effects of age on personality, driving behavior towards driving outcomes
Authors: Haerani Siti , Parmitasari Rika Dwi Ayu , Aponno Elsina Huberta , Aunalal Zany Irayati 
Published: September 2018

PurposeThe purpose of this paper is to identify the effect of people’s personality on driving behavior and traffic accidents and violations in the province of South Sulawesi.Design/methodology/approachThis research was conducted in order to determine the moderating effects of age on the relationship between personality variables, driving behavior and driving outcomes. The research was conducted over two years. For the first year of this study, research was conducted in the city of Makassar, the capital of the South Sulawesi province, which has the highest volume of accidents compared to other districts/cities in South Sulawesi. The approach used in conducting the data analysis was a quantitative approach; the inferential statistical analysis method of analysis used to test the hypothesis of the research was structural equation modeling.FindingsThe results of the analysis show that age is a moderating variable in the relationship between personality, driving behavior and driving outcomes. The higher the age, the stronger the influence of personality on driving behavior and driving outcomes, and the stronger the effect of driving behavior on driving outcomes.Originality/valueOriginality for this paper is shown as follows: using age on personality has a moderating effect on the relationship between driving behavior and driving outcomes; and the research would implicate driving behavior and inclined factors from the eastern part of Indonesia, since most research works were conducted in the western part of Indonesia and they hardly considered the moderating effect of age.
Deterrence effects, socio-economic development, police revenge and homicides in Rio de Janeiro
Authors: Montes Gabriel Caldas , Lins Gabriel Oliveira 
Published: September 2018

PurposeDue to the high levels of crime in Rio de Janeiro, the purpose of this paper is twofold. The first one is to analyze the effects of deterrence variables (such as the adoption of Pacifying Police Units (UPPs) and incarcerations) on violence in the municipalities of the State of Rio de Janeiro, as well as to verify the existence of “revenge effect.” The second is to analyze the effects of socio-economic development on violence, using development indicators.Design/methodology/approachBesides usual OLS method for panel data analysis, the study makes use of dynamic panel data framework through D-GMM and S-GMM. The estimates are based on a sample of 82 municipalities of Rio de Janeiro, and the period runs from 2003 to 2013. As dependent variables, the estimates use violent deaths (i.e. aggregation of intentional homicides and armed robberies followed by death) and homicides resulting from opposition to police intervention (i.e. civilians killed as a result of police actions against criminals – “opposition deaths”).FindingsThe estimates indicate that incarceration presents marginal capacity to reduce violence. Regarding the findings for the adoption of UPPs, the evidence suggests that this project increased violence and, therefore, the possibility of displacement of violence to other regions of the State. With respect to the effect of police deaths over violence, the results are unprecedented and suggest the existence of a “revenge effect.” Besides, the study points to the importance of socio-economic development to reduce violence.Originality/valueOnce the study analyzes the effects of incarceration and UPPs, it contributes to the literature by providing new evidence on the ability of anti-crime policies of reducing (or not) violence. In addition, when considering the death of policemen in the estimates, the study shows an unprecedented way, the effect that these deaths cause over violence (the so-called “revenge effect”). Moreover, the study considers the impacts of the development of employment and income, health and education on violence. When analyzing these development indicators, the study contributes with the literature that looks for non-police alternatives to control crime.
Work-task types, stages, and information-seeking behavior of strategic planners
Authors: Li Yuelin , Li Ying , Pan Ying , Han Hongliang 
Published: September 2018

PurposeThe purpose of this paper is to examine information-seeking behavior (ISB) of strategic planners in enterprise across different work-task types and stages.Design/methodology/approachA case study was conducted in a pharmaceutical company in China, labeled as T Company. One of the authors worked in the department of strategic planning of this company as an intern. The data were collected via participant observation and unstructured in-depth interviews. Open coding was performed to analyze the data.FindingsFour work-task stages were identified: project preparation, gathering, discovery and presentation, and strategy formulation. The results indicate that work-task types, work-task stages, and strategic planners’ work role or position affect their information needs, source selection, and seeking process. Task complexity, task familiarity, and task goal are of the most important task attributes that directly shape strategic planners’ ISB. Work role determines the extent to which strategic planners can access the information of the company. Internal information has priority, but external information is also important when internal information is not sufficient; both are equally important for strategic planning projects. Social media has been a very important channel to access, disseminate and share information. Workshops are an important approach to producing final project reports. Face-to-face discussion and information exchange play a critical role in the formulation of new strategies.Research limitations/implicationsThis is a case study with data collected from only one company in China. Some of the results may not be generalizable. However, it adds new knowledge to ISB research in enterprise, informs people how to provide better information services for strategic planners, and informs MBA education for students’ better information-seeking skills.Originality/valueThough myriad studies on ISB, little research has been done to examine strategic planners’ ISB from a business context, especially taking into account the effect of work-task types and stages.
Examination of the congestion situation of a restaurant in a theme park using feedback control
Authors: Sakamoto Noriaki 
Published: September 2018

PurposeThis paper aims to examine a congestion situation of a certain type of restaurant in a theme park (Tokyo Disney Resort) by a simulation based on Little’s law, which is a basic principle in Queueing theory. In the restaurant, a guest (customer) lines up to order, pay and receive dishes. A problem is that even when a guest can easily find vacant tables, it takes a long time to receive dishes. Because guests can see there are vacant tables, there are many tweets of complaints. This situation is a factor to undermine customer satisfaction.Design/methodology/approachThis paper proposes dedicated special menu lines only providing special set as one solution that can be realized at a low cost to reduce vacant tables. Here, if the number of special menu lines is fixed, the difference between a queue in regular lines and that in special menu lines will be big. To shorten the difference, the author proposes a technique to regulate by using feedback control (Proportional control or Fuzzy control).FindingsThe simulation result shows that the number of vacant tables decreases by about 16 per cent compared with the current situation.Originality/valueThis paper considers a specific restaurant, but the proposed method can be applied to the same type of restaurant in the theme park. If the restaurant in the theme park is crowded, the feedback control of the queue brings new possibilities.
Fuzzy logic-based bidding strategies in dynamic double auctions
Authors: Unal Baki , Aladag Çagdas Hakan 
Published: September 2018

PurposeDouble auctions are widely used market mechanisms on the world. Communication technologies such as internet increased importance of this market institution. The purpose of this study is to develop novel bidding strategies for dynamic double auction markets, explain price formation through interactions of buyers and sellers in decentralized fashion and compare macro market outputs of different micro bidding strategies.Design/methodology/approachIn this study, two novel bidding strategies based on fuzzy logic are presented. Also, four new bidding strategies based on price targeting are introduced for the aim of comparison. The proposed bidding strategies are based on agent-based computational economics approach. The authors performed multi-agent simulations of double auction market for each suggested bidding strategy. For the aim of comparison, the zero intelligence strategy is also used in the simulation study. Various market outputs are obtained from these simulations. These outputs are market efficiencies, price means, price standard deviations, profits of sellers and buyers, transaction quantities, profit dispersions and Smith’s alpha statistics. All outputs are also compared to each other usingt-tests and kernel density plots.FindingsThe results show that fuzzy logic-based bidding strategies are superior to price targeting strategies and the zero intelligence strategy. The authors also find that only small number of inputs such as the best bid, the best ask, reference price and trader valuations are sufficient to take right action and to attain higher efficiency in a fuzzy logic-based bidding strategy.Originality/valueThis paper presents novel bidding strategies for dynamic double auction markets. New bidding strategies based on fuzzy logic inference systems are developed, and their superior performances are shown. These strategies can be easily used in market-based control and automated bidding systems.
Incorporating medical leadership into undergraduate curricula: a proposal for a spiral curriculum
Authors: Lamont Ross I. , Chapman Ann L.N. 
Published: September 2018

Purpose
There is increasing recognition of the importance of incorporating medical leadership training into undergraduate medical curricula and this is now advocated by the General Medical Council (GMC) and supported through the development of the Undergraduate Medical Leadership Competency Framework (MLCF). However to date, few medical schools have done so in a systematic way and training/experience in medical leadership at undergraduate level is sporadic and often based on local enthusiasm. The purpose of this paper is to outline a theoretical curriculum to stimulate and support medical leadership development at undergraduate level.

Design/methodology/approach
This study describes a theoretical framework for incorporation of medical leadership training into undergraduate curricula using a spiral curriculum approach, linked to competences outlined in the Undergraduate Medical Leadership Competency Framework. The curriculum includes core training in medical leadership for all students within each year group with additional tiers of learning for students with a particular interest.

Findings
This curriculum includes theoretical and practical learning opportunities and it is designed to be deliverable within the existing teaching and National Health Service (NHS) structures. The engagement with local NHS organisations offers opportunities to broaden the university teaching faculty and also to streamline medical leadership development across undergraduate and postgraduate medical education.

Originality/value
This theoretical curriculum is generic and therefore adaptable to a variety of undergraduate medical courses. The combination of theoretical and practical learning opportunities within a leadership spiral curriculum is a novel and systematic approach to undergraduate medical leadership development.
Mediating effect of online social support on the relationship between stress and mental well-being
Authors: Xavier Naveenraj , J. Reeves Wesley 
Published: September 2018

Purpose
Workplace stress is on the rise and progressive organizations devise their own mechanisms to mitigate it and enhance mental wellbeing (MWB). Of late, the workforce is increasingly dependent on social networking sites (SNS) for social exchanges and debate is well documented if SNS could be used to mediate the relationship between stress and MWB. The purpose of this paper is to investigate this relationship.

Design/methodology/approach
This study is based on a survey of 269 employees, on the following constructs: stress, online social support (OSS) and MWB. The authors’ proposed framework was investigated using structural equation modeling.

Findings
Results indicated that stress has a significant negative effect on MWB and subsequently, OSS partially mediates the relationship between stress and MWB. The results suggest that organizations allow the use of social networking site in a controlled setting so that employees could use this as a mechanism to control stress and enhance MWB.

Originality/value
To the best of the authors’ knowledge, this is the first study on OSS role in mediating the relationship between stress and MWB.