bluuebunny/crossref_metadata_2025_split huggingface dataset:
A prophylaxis study of acute exacerbation of interstitial pneumonia after lung cancer surgery
Authors: Ito Hiroyuki , Nakayama Haruhiko , Yokose Tomoyuki , Nagashima Takuya , Morohoshi Takao , Tajiri Michihiko , Maehara Takamitsu , Watanabe Katsuya , Arai Hiromasa , Yamamoto Taketsugu , Woo Tekkan , Nishii Teppei , Ishikawa Yoshihiro , Morita Satoshi , Masuda Munetaka 
Published: October 2019

Abstract

Introduction
Acute exacerbation of interstitial pneumonia (AE-IP) is a lethal complication after lung surgery. We conducted a prospective, multi-institutional phase II trial to assess the efficacy and safety of prophylactic measures.

Method
Patients with lung cancer with dorsal subpleural fibrotic changes occupying three or more segments of both lower lobes and planned anatomical lung resection were enrolled. Prior to surgery, patients received a 125-mg bolus injection of methylprednisolone and continuous intravenous infusion of sivelestat sodium hydrate (sivelestat) for 2 days.

Results
Sixty-nine patients were analysed. Preoperative high-resolution computed tomography (HRCT) showed 37 (53.6%) cases presented with usual interstitial pneumonia (UIP) and possible UIP pattern. There were 60 lobectomies and 9 segmentectomies. Thirty-eight cases were in clinical stage I. No adverse events associated with prophylaxis were observed. There were four cases of AE-IP (5.8%), higher than the expected 2.0%. Three of the four cases showed inconsistencies with the UIP pattern in preoperative HRCT and were pathologically diagnosed as UIP. All patients died of respiratory failure. Overall, 89.9% were diagnosed as idiopathic interstitial pneumonias; UIP was found in 48 patients (69.6%). Severe post-operative complications occurred in 11.6% of the cases. There were 35 deaths, 17 cases of lung cancer and 11 cases related to interstitial pneumonias. The overall survival rate at 3 years was 41.8% of the total and 47.2% of cases with clinical stage I.

Conclusions
Perioperative use of sivelestat and low-dose methylprednisolone in patients with anatomical lung resection was safe but did not prove to be a prophylactic effect for AE-IP.
Visualization of different carrier concentrations in n-type-GaN semiconductors by phase-shifting electron holography with multiple electron biprisms
Authors: Yamamoto Kazuo , Nakano Kiyotaka , Tanaka Atsushi , Honda Yoshio , Ando Yuto , Ogura Masaya , Matsumoto Miko , Anada Satoshi , Ishikawa Yukari , Amano Hiroshi , Hirayama Tsukasa 
Published: October 2019

Abstract
Phase-shifting electron holography (PS-EH) using a transmission electron microscope (TEM) was applied to visualize layers with different concentrations of carriers activated by Si (at dopant levels of 1019, 1018, 1017 and 1016 atoms cm−3) in n-type GaN semiconductors. To precisely measure the reconstructed phase profiles in the GaN sample, three electron biprisms were used to obtain a series of high-contrast holograms without Fresnel fringes generated by a biprism filament, and a cryo-focused-ion-beam (cryo-FIB) was used to prepare a uniform TEM sample with less distortion in the wide field of view. All layers in a 350-nm-thick TEM sample were distinguished with 1.8-nm spatial resolution and 0.02-rad phase-resolution, and variations of step width in the phase profile (corresponding to depletion width) at the interfaces between the layers were also measured. Thicknesses of the active and inactive layers at each dopant level were estimated from the observed phase profile and the simulation of theoretical band structure. Ratio of active-layer thickness to total thickness of the TEM sample significantly decreased as dopant concentration decreased; thus, a thicker TEM sample is necessary to visualize lower carrier concentrations; for example, to distinguish layers with dopant concentrations of 1016 and 1015 atoms cm−3. It was estimated that sample thickness must be more than 700 nm to make it be possible to detect sub-layers by the combination of PS-EH and cryo-FIB.
Race, Socioeconomic Status, and Health-Care Access Disparities in Ovarian Cancer Treatment and Mortality: Systematic Review and Meta-Analysis
Authors: Karanth Shama , Fowler Mackenzie E , Mao XiHua , Wilson Lauren E , Huang Bin , Pisu Maria , Potosky Arnold , Tucker Tom , Akinyemiju Tomi 
Published: October 2019

Abstract

Background
Ovarian cancer remains a leading cause of death from gynecological malignancies. Race, socioeconomic status (SES), and access to health care are important predictors of quality treatment and survival. We provide a systematic review and meta-analysis on the role of these predictors on disparities in ovarian cancer treatment and mortality.

Methods
Using the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines, we searched PubMed, EMBASE, and Scopus for relevant articles published between January 2000 and March 2017. We selected studies published in the United States that evaluated the role of race, SES, or health-care access on disparities in ovarian cancer treatment or survival. Pooled relative risk (RR) and 95% confidence intervals (CIs) were calculated for each outcome using a random-effects model.

Results
A total of 41 studies met the inclusion criteria for systematic review. In meta-analysis, there was a 25% decrease (RR = 0.75, 95% CI = 0.66 to 0.84) in receipt of adherent ovarian cancer treatment and 18% increased risk (RR = 1.18, 95% CI = 1.11 to 1.26) of mortality for blacks compared to whites. Receipt of adherent ovarian cancer treatment was 15% lower (RR = 0.85, 95% CI = 0.77 to 0.94) in the lowest vs highest SES group and 30% lower (RR = 0.70, 95% CI = 0.58 to 0.85) among patients at lower vs higher hospital volumes.

Conclusion
We found consistent and strong evidence for continued lack of quality ovarian cancer treatment and higher mortality among ovarian cancer patients who are black, are of low SES, and/or have poor access to care. Interventions focused on these groups targeting specific barriers to care are needed to reduce disparities in ovarian cancer treatment and mortality.
Building Resilience by Becoming a Circus Artist
Authors: VAN ES VERA , ROMMES ELS , De Kwaadsteniet Leontien 
Published: October 2019

AbstractDue to the traumatic events they may have experienced, refugee youth are vulnerable to mental health problems. Social Circus is a psycho-social intervention that aims to enhance resilience by promoting self-esteem, interpersonal trust and social support through classes in circus arts. To explore these effects on refugee youth, a qualitative study was conducted in south-east Turkey. Semi-structured interviews and participative observations revealed that circus classes offered participants structure and a new purpose in life. Participating youth became more active, while impulsive behaviour decreased. Experiencing success through visible progress and holding the positively valued position of a circus artist seemed to contribute to the children’s self-esteem. In addition, the mental and physical support received during circus classes could increase interpersonal trust. By creating opportunities for social interaction and building relationships, Social Circus may also promote social support. This study provides preliminary evidence that Social Circus may enhance resilience in refugee youth.
Higher Education in the Context of Mass Displacement: Towards Sustainable Solutions for Refugees
Authors: Pherali Tejendra , Abu Moghli Mai 
Published: October 2019

AbstractThis article provides a theoretical review of higher-education (HE) access for refugees in humanitarian situations. Drawing upon the case of Syrian refugees in Lebanon, we discuss challenges and opportunities around developing new HE modalities to enhance its role in the humanitarian response as well as reconfiguring refugees’ ‘unknowable future’. We also examine opportunities for HE access and the process of multidimensional partnerships, engaging with emerging practices and experiments in this sector from the perspective of future education and highlighting the opportunities that investment in HE can serve for solidarity and peace in contexts of mass displacement. Finally, we reflect upon possible ways forward and offer insights into potential sustainable solutions not only for Syrian refugees in Lebanon, but also for young displaced populations globally.
Acculturation, Social Support and Mental Health Outcomes among Syrian Refugees in Germany
Authors: Green Molly , King Elizabeth , Fischer Florian 
Published: October 2019

Abstract
Syrian refugees in Germany number around 700,000 and they are managing acculturation and mental health issues. In May–July 2018, we conducted a cross-sectional survey among 97 Syrian refugees in Germany using measures of acculturation, social support, depressive symptoms and wellbeing. We ran linear-regression models and created an interaction term of two aspects of acculturation, focused on the outcomes of depressive symptoms and wellbeing, along with the possible moderation of social support. Affiliation with German culture was positively associated with wellbeing. More acculturation to German culture may promote positive mental health. Higher levels of social support were associated with lower levels of wellbeing and higher levels of depressive symptoms; this could reflect reverse causality or more connections with those back home. This study provides insight into acculturation and mental health among a significant refugee population in Germany.
Imported dengue in Spain: a nationwide analysis with predictive time series analyses
Authors: Redondo-Bravo Lidia , Ruiz-Huerta Claudia , Gomez-Barroso Diana , Sierra-Moros María José , Benito Agustín , Herrador Zaida 
Published: October 2019

AbstractBackgroundOf febrile illnesses in Europe, dengue is second only to malaria as a cause of travellers being hospitalized. Local transmission has been reported in several European countries, including Spain. This study assesses the evolution of dengue-related admissions in Spain in terms of time, geographical distribution and individuals’ common characteristics; it also creates a predictive model to evaluate the risk of local transmission.MethodsThis is a retrospective study using the Hospital Discharge Records Database from 1997 to 2016. We calculated hospitalization rates and described clinical characteristics. Spatial distribution and temporal behaviour were also assessed, and a predictive time series model was created to estimate expected cases in the near future. Figures for resident foreign population, Spanish residents’ trips to endemic regions and the expansion of Aedes albopictus were also evaluated.ResultsA total of 588 dengue-related admissions were recorded: 49.6% were women, and the mean age was 34.3 years. One person died (0.2%), 82% presented with mild-to-moderate dengue and 7–8% with severe dengue. We observed a trend of steady and consistent increase in incidence (P &lt; 0.05), in parallel with the increase in trips to dengue-endemic regions. Most admissions occurred during the summer, showing significant seasonality with 3-year peaks. We also found important regional differences. According to the predictive time series analysis, a continuing increase in imported dengue incidence can be expected in the near future, which, in the worst case scenario (upper 95% confidence interval), would mean an increase of 65% by 2025.ConclusionWe present a nationwide study based on hospital, immigration, travel and entomological data. The constant increase in dengue-related hospitalizations, in combination with wider vector distribution, could imply a higher risk of autochthonous dengue transmission in the years to come. Strengthening the human and vector surveillance systems is a necessity, as are improvements in control measures, in the education of the general public and in fostering their collaboration in order to reduce the impact of imported dengue and to prevent the occurrence of autochthonous cases.
Pharmacokinetics of voriconazole after a single intramuscular injection in large falcons (Falco spp.)
Authors: Azmanis P , Pappalardo L , Sara Ziad A J , Silvanose C , Naidoo V 
Published: October 2019

Abstract
Voriconazole is one of the main azoles used to treat invasive aspergillosis in falconry raptors and birds. Despite the fact that there are studies for oral and intravenous use of voriconazole in birds, there are none for its effect after intramuscular use. Empirical use of intramuscular voriconazole in falcons, indicated quicker therapy response than the oral one. Aim of this study is to evaluate the in vivo pharmacokinetic disposition of injectable voriconazole after a single intramuscular injection in large falcons (i.e., Gyrfalcons, Saker falcons, Peregrine falcons). No clinical side effects were observed in the falcons. Absorption of voriconazole was rapid (0.5–2 hours) and reached a plasma level (&gt;1 μg/ml) which is above the minimal inhibitory concentration (MIC) for all known Aspergillus strains. This level was maintained for 16 to 20 hours, thus indicating that a single injection of 12.5 mg/kg is not enough if T &gt; MIC is taken into consideration. On a newer aspect, according to the AUC24 unbound: MIC parameter would be indicated that this dose would be rather sufficient for most Aspergillus strains.
Molecules in the Cep E-mm jet: evidence for shock-driven photochemistry?
Authors: Ospina-Zamudio J , Lefloch B , Favre C , López-Sepulcre A , Bianchi E , Ceccarelli C , De Simone M , Bouvier M , Kahane C 
Published: October 2019

ABSTRACT
The chemical composition of protostellar jets and its origin are still badly understood. More observational constraints are needed to make progress. With that objective, we have carried out a systematic search for molecular species in the jet of Cep E-mm, a template for intermediate-mass Class 0 protostars, associated with a luminous, high-velocity outflow. We made use of an unbiased spectral line survey in the range 72–350 GHz obtained with the IRAM 30-m telescope, complementary observations of the CO J = 3–2 transition with the JCMT, and observations at 1 arcsec angular resolution of the CO J = 2–1 transition with the IRAM Plateau de Bure Interferometer. In addition to CO, we have detected rotational transitions from SiO, SO, H2CO, CS, HCO+, and HCN. A strong chemical differentiation is observed in the southern and northern lobes of the jet. Radiative transfer analysis in the large velocity gradient approximation yields typical molecular abundances of the order of 10−8 for all molecular species other than CO. Overall, the jets exhibit an unusual chemical composition, as CS, SO, and H2CO are found to be the most abundant species, with a typical abundance of (3–4)× 10−8. The transverse size of the CO jet emission estimated from interferometric observations is about 1000 au, suggesting that we are detecting emission from a turbulent layer of gas entrained by the jet in its propagation and not the jet itself. We propose that some molecular species could be the signatures of the specific photochemistry driven by the UV radiation field generated in the turbulent envelope.
Herschel spectroscopy of massive young stellar objects in the Magellanic Clouds
Authors: Oliveira J M , van Loon J Th , Sewiło M , Lee M-Y , Lebouteiller V , Chen C-H R , Cormier D , Filipović M D , Carlson L R , Indebetouw R , Madden S , Meixner M , Sargent B , Fukui Y 
Published: October 2019

ABSTRACT
We present Herschel Space Observatory Photodetector Array Camera and Spectrometer (PACS) and Spectral and Photometric Imaging Receiver Fourier Transform Spectrometer (SPIRE FTS) spectroscopy of a sample of 20 massive Young Stellar Objects (YSOs) in the Large and Small Magellanic Clouds (LMC and SMC). We analyse the brightest far-infrared (far-IR) emission lines, that diagnose the conditions of the heated gas in the YSO envelope and pinpoint their physical origin. We compare the properties of massive Magellanic and Galactic YSOs. We find that [O i] and [C ii] emission, that originates from the photo-dissociation region associated with the YSOs, is enhanced with respect to the dust continuum in the Magellanic sample. Furthermore the photoelectric heating efficiency is systematically higher for Magellanic YSOs, consistent with reduced grain charge in low metallicity environments. The observed CO emission is likely due to multiple shock components. The gas temperatures, derived from the analysis of CO rotational diagrams, are similar to Galactic estimates. This suggests a common origin to the observed CO excitation, from low-luminosity to massive YSOs, both in the Galaxy and the Magellanic Clouds. Bright far-IR line emission provides a mechanism to cool the YSO environment. We find that, even though [O i], CO, and [C ii] are the main line coolants, there is an indication that CO becomes less important at low metallicity, especially for the SMC sources. This is consistent with a reduction in CO abundance in environments where the dust is warmer due to reduced ultraviolet-shielding. Weak H2O and OH emission is detected, consistent with a modest role in the energy balance of wider massive YSO environments.
Predicting the LISA white dwarf binary population in the Milky Way with cosmological simulations
Authors: Lamberts Astrid , Blunt Sarah , Littenberg Tyson B , Garrison-Kimmel Shea , Kupfer Thomas , Sanderson Robyn E 
Published: October 2019

ABSTRACT
White dwarf binaries with orbital periods below 1 h will be the most numerous sources for the space-based gravitational wave detector Laser Interferometer Space Antenna (LISA). Based on thousands of individually resolved systems, we will be able to constrain binary evolution and provide a new map of the Milky Way and its close surroundings. In this paper we predict the main properties of populations of different types of detached white dwarf binaries detected by LISA over time. For the first time, we combine a high-resolution cosmological simulation of a Milky Way-mass galaxy (taken from the FIRE project) with a binary population synthesis model for low- and intermediate-mass stars. Our Galaxy model therefore provides a cosmologically realistic star formation and metallicity history for the Galaxy and naturally produces its different components such as the thin and thick disc, the bulge, the stellar halo, and satellite galaxies and streams. Thanks to the simulation, we show how different Galactic components contribute differently to the gravitational wave signal, mostly due to their typical age and distance distributions. We find that the dominant LISA sources will be He–He double white dwarfs (DWDs) and He–CO DWDs with important contributions from the thick disc and bulge. The resulting sky map of the sources is different from previous models, with important consequences for the searches for electromagnetic counterparts and data analysis. We also emphasize that much of the science-enabling information regarding white dwarf binaries, such as the chirp mass and the sky localization, becomes increasingly rich with long observations, including an extended mission up to 8 yr.
Crust of accreting neutron stars within simplified reaction network
Authors: Shchechilin N N , Chugunov A I 
Published: October 2019

ABSTRACT
Transiently accreting neutron stars in low-mass X-ray binaries are generally believed to be heated up by nuclear reactions in accreted matter during hydrostatic compression. Detailed modelling of these reactions is required for the correct interpretation of observations. In this paper, we construct a simplified reaction network, which can be easily implemented and depends mainly on atomic mass tables as nuclear physics input. We show that it reproduces results of the detailed network by Lau et al. very well, if one applies the same mass model. However, the composition and the heating power are shown to be sensitive to the mass table used and treatment of mass tables boundary, if one applies several of them in one simulation. In particular, the impurity parameter Qimp at density ρ = 2 × 1012 g cm−3 can differ for a factor of few, and even increase with density increase. The profile of integrated heat release shown to be well confined between results by Fantina et al. and Lau et al.
Mutual approximations between the five main moons of Uranus
Authors: Santos-Filho S , Assafin M , Morgado B E , Vieira-Martins R , Camargo J I B , Gomes-Júnior A R , Benedetti-Rossi G 
Published: October 2019

ABSTRACT
Doing high-precision astrometry on Uranus’ moons is currently quite challenging. No probes will orbit the system before 2040. New high-precision mutual phenomena measurements will only occur in 2050. Besides, Uranus is slowly passing through a sky region without many stars, which makes it difficult to map field of view (FOV) distortions below 50 mas. In this context, the new astrometric technique of mutual approximations comes in handy. It measures central instants at the closest approach between two moving satellites in the sky plane. Measurements are made on small portions of the FOV, benefiting from the so-called precision premium. Approximations and mutual phenomena share geometric principles and parameters, with similar precision in the central instant as indicated by first applications to the Jovian moons. However, mutual phenomena can only be observed at the planet’s equinoxes, while approximations always occur. Central instants do not depend on reference stars and are useful in orbit and ephemeris fittings. Here, we present results for 23 mutual approximations between the five main Uranus satellites observed in Brazil during 2015–2018 with a 1.6 m aperture telescope. Digital coronagraphy mitigated Uranus’ scattered light, improving measurements for Miranda, Ariel and Umbriel. We measured the impact parameter and relative velocity in milliarcseconds for the first time by using a variant of the method. Relative position errors, including Miranda, were 45 mas per coordinate, twice as good as in classical CCD astrometry for this satellite, and comparable to mutual phenomena. This shows the potential of mutual approximations for improving the current orbits and ephemerides of Uranus’ moons.
PathBank: a comprehensive pathway database for model organisms
Authors: Wishart David S , Li Carin , Marcu Ana , Badran Hasan , Pon Allison , Budinski Zachary , Patron Jonas , Lipton Debra , Cao Xuan , Oler Eponine , Li Krissa , Paccoud Maïlys , Hong Chelsea , Guo An C , Chan Christopher , Wei William , Ramirez-Gaona Miguel 
Published: October 2019

Abstract
PathBank (www.pathbank.org) is a new, comprehensive, visually rich pathway database containing more than 110 000 machine-readable pathways found in 10 model organisms (Homo sapiens, Bos taurus, Rattus norvegicus, Mus musculus, Drosophila melanogaster, Caenorhabditis elegans, Arabidopsis thaliana, Saccharomyces cerevisiae, Escherichia coli and Pseudomonas aeruginosa). PathBank aims to provide a pathway for every protein and a map for every metabolite. This resource is designed specifically to support pathway elucidation and pathway discovery in transcriptomics, proteomics, metabolomics and systems biology. It provides detailed, fully searchable, hyperlinked diagrams of metabolic, metabolite signaling, protein signaling, disease, drug and physiological pathways. All PathBank pathways include information on the relevant organs, organelles, subcellular compartments, cofactors, molecular locations, chemical structures and protein quaternary structures. Each small molecule is hyperlinked to the rich data contained in public chemical databases such as HMDB or DrugBank and each protein or enzyme complex is hyperlinked to UniProt. All PathBank pathways are accompanied with references and detailed descriptions which provide an overview of the pathway, condition or processes depicted in each diagram. Every PathBank pathway is downloadable in several machine-readable and image formats including BioPAX, SBML, PWML, SBGN, RXN, PNG and SVG. PathBank also supports community annotations and submissions through the web-based PathWhiz pathway illustrator. The vast majority of PathBank's pathways (&gt;95%) are not found in any other public pathway database.