bluuebunny/crossref_metadata_2025_split huggingface dataset:
Radiosynthesis of [18F]-flumazenil Using an Isotopic Approach
Authors: Thakur Riptee , Kumar Aishwarya , Joshi Raman Kumar , Kumar Pardeep 
Published: November 2024

Background:
Fluorine-18 (18F) flumazenil (FMZ) has been synthesized using various precursors, and its role has been explored in imaging Gamma-aminobutyric acid-A receptors.

Aim and Objective:
The main objective was to synthesize (18F) FMZ using isotopic substitution.

Materials and Methods:
Around 18 ± 2 GBq was added to the module, dried, and radiolabeling was standardized with 3.0 mg of the FMZ precursor at various temperatures (110°C –160°C) for 10–30 min. The product was finally eluted with 20% ethanol (in phosphate buffer). The final product was characterized by high-performance liquid chromatography (HPLC). The stability was evaluated in water, saline, and phosphate-buffered saline for 4 h.

Results:
The radiolabelling efficiency of cartridge-based purification was 16 ± 4% (n = 10) with a radiochemical purity of 96.5 ± 1.8%, whereas in HPLC-based purification, the yield was 10 ± 4% (n = 5) with a radiochemical purity of 97.3 ± 1.4%. The specific activity was 120 ± 20 GBq/μmol.

Conclusions:
(18F) FMZ was successfully synthesized using an isotopic approach and could be used as an alternative cheaper option for the synthesis.
Optimizing Low-Dose [18F]FDG-PET/CT Scans: Ensuring Quality Amid Radiotracer Availability Challenges – Insights from a Peripheral Tertiary Care Center
Authors: Tayal Sachin , Jain Yash , Thakur Sonali , Shukla Varun , Venkatachalam Manikandan Marappagounder , Kumar Ajay , Sinha Ritwik 
Published: November 2024

Background:
The introduction of positron emission tomography/computed tomography (PET/CT) has significantly advanced medical imaging. In oncology, 18F-fluorodeoxyglucose (18F-FDG) PET/CT is particularly crucial for staging, evaluating treatment response, monitoring follow-up, and planning radiotherapy. However, in resource limiting hospitals, the availability of fluorine-labeled 18F-FDG limits optimal scan acquisition. This study aims to determine the optimal dosage and acquisition time to maximize patient throughput during shortages.

Aim and Objective:
To optimize low-dose 18F-FDG scan protocols while maintaining high image quality despite radiotracer availability challenges.

Materials and Methods:
PET/CT scans were performed using GE’s Discovery IQ 5-ring, 16-slice system within 40–60 minutes of intravenous 18F-FDG injection. The protocol was adjusted to a low-dose (0.05 mCi/kg of 18F-FDG), and the PET data acquisition time was increased to 3 min per bed position to ensure image quality.

Results:
Notable differences were observed in image quality scores based on varying acquisition times, with the extended acquisition time helping maintain diagnostic standards despite reduced tracer doses.

Conclusion:
The high sensitivity and long axial length of the PET/CT system (with five rings spanning 26 cm AFOV) can significantly alleviate the challenges faced by cyclotron-dependent centers. By leveraging the increased sensitivity, we successfully reduced the injected activity rather than the scan time to address the tracer shortage at our institute. This approach proved to be effective in maintaining image quality and patient care standards.
Phytochemical screening of hydroethanolic Murraya koenigii Spreng leaves extract by spectroscopic methods
Authors: Aniqa Aniqa , Kaur Sarvnarinder 
Published: November 2024

Abstract

BACKGROUND:

Murraya koenigii (MK) L. Spreng is indigenous to India, Sri Lanka, and other South Asian nations. It is a renowned culinary spice in several Asian cuisines and is commonly used in the Indian cookery system due to its characteristic aroma and flavor. Despite its traditional usage, there is a scarcity of scientific research conferring the therapeutic effects of curry trees. We believe that MK has a plethora of active phytochemicals, which could be utilized in the drug discovery and drug development industry to tackle several diseases. Thus, the present study was conducted to investigate various phytochemicals and essential oils present in hydroethanolic Murraya koenigii leaves extract (HEMKLE) by spectroscopic analyses.

METHODS:
Spectroscopic screening of HEMKLE was performed by energy dispersive X-ray (EDX) spectroscopy, Fourier transform infrared (FTIR) spectroscopy, liquid chromatography-mass spectroscopy (LC-MS), and gas chromatography-mass spectroscopy (GC-MS) techniques.

RESULTS:
EDX spectroscopy revealed the presence of trace elements viz., carbon, oxygen, nitrogen, copper, iron, tin, and sulfur in HEMKLE. the FTIR spectrum revealed the presence of functional groups corresponding to alkaloids, phenols, amino acids, carboxylic acids, aliphatic amines, and alkyl halides within MK extract. Furthermore, LC-MS exposed the presence of polyphenols and carbazole alkaloids within HEMKLE. GC-MS analysis revealed the presence of volatile compounds within HEMKLE.

CONCLUSION:
The presence of polyphenols, carbazole alkaloids, terpenoids, and volatile organic compounds within HEMKLE could be bestowing several pharmacological properties to HEMKLE, which could be utilized from drug development in the pharmaceutical industry for future use.
Bee pollen beyond nutrition: An integrated review of its chemical, pharmacological, and biological properties
Authors: Rupanar Shobha Vasant , Satpute Rituja , Gadhave Prakash , Kakade Nirmala 
Published: November 2024

Abstract
Bee pollen, renowned for its nutritional richness and therapeutic properties, harbors a complex array of compounds influenced by geographical origins and plant sources. In recent years, bee pollen has gained significant attention owing to its recognized potential health benefits and nutritional value. A systematic review was undertaken, encompassing peer-reviewed articles, clinical trials, and ethnobotanical studies, to gather pertinent information on bee pollen, its chemical constituents, and its physiological effects on human health. The assessment emphasizes the complex chemical composition of bee pollen, comprising carbohydrates, proteins, amino acids, lipids, vitamins, minerals, and bioactive compounds like flavonoids, phenolic acids, and enzymes. Various analytical methods have been employed to characterize the components of bee pollen, highlighting its complex composition. Bee pollen contains life-essential proteins, making up an average of 22.7%, and essential amino acids such as isoleucine, lysine, threonine, histidine, leucine, valine, phenylalanine, methionine, and tryptophan. Geographical variations emphasize its diversity, underscoring the need for comprehensive analysis. Contemporary scientific investigations have initiated the revelation of bee pollen’s potential health benefits. Beyond its nutritional value, bee pollen exhibits a spectrum of biological activities, including antimicrobial, antifungal, antioxidant, anti-tumor, neuroprotective, anti-inflammatory, anticancer, immunostimulatory, and hepatoprotective effects, suggesting its therapeutic value in addressing a spectrum of health conditions. Additionally, its biological effects on different physiological systems, such as the cardiovascular, digestive, reproductive, and respiratory systems, are explored. Recognized as a pivotal resource for medicinal development, bee pollen warrants systematic and scientific scrutiny to fully unravel its multifaceted activities and therapeutic potential. The objective of this study is to offer a thorough exploration of the background and existing scientific literature concerning bee pollen. The study seeks to examine in detail the composition, nutritional importance, therapeutic applications, and potential health benefits associated with bee pollen. Further exploration of bee pollen may pave the way for the creation of innovative therapeutic agents and nutritional supplements, enriching both traditional and evidence-based healthcare approaches.
Retrospective Analysis of the Risk of Breast Carcinoma Following Recurrent In vitro Fertilization Treatments
Authors: Mathur Tanuj , Vishwapriyanka G. , Kumar Bipin , Chaitanya Perugu Damodara Krishna 
Published: November 2024

ABSTRACT

Background:
Breast cancer is one of the most common cancers affecting women globally, with risk factors including genetic predisposition, environmental influences, and hormonal exposure. The use of in vitro fertilization (IVF) has been associated with high doses of hormonal treatments, raising concerns about the potential increase in breast cancer risk due to these treatments. This study aims to evaluate the incidence of breast carcinoma following recurrent IVF treatments.

Methodology:
This retrospective cohort study involved 62 women who underwent three or more IVF cycles at a single fertility clinic. Participants were selected based on their comprehensive medical records from the clinic’s database, excluding those with known genetic predispositions to breast cancer. The study cohort was compared with a control group of 62 women who did not undergo IVF but were matched for age and socioeconomic status. Breast cancer incidence was identified through cross-referencing participant records with national cancer registries.

Results:
Of the 62 women in the IVF group, 8 (12.9%) developed breast carcinoma compared to 4 (6.5%) in the control group. The median time from the first IVF treatment to the cancer diagnosis was 7 years. Statistical analysis using Cox proportional hazards models revealed a hazard ratio of 2.1 for developing breast carcinoma among IVF participants compared to controls, although this was not statistically significant (95% confidence interval: 0.8–5.4; P = 0.12).

Conclusion:
The findings suggest a higher incidence of breast carcinoma in women undergoing recurrent IVF treatments compared to those who did not undergo such treatments, although the results did not reach statistical significance. The study highlights the need for further research with larger cohorts to robustly determine the relationship between IVF treatments and breast cancer risk. Enhanced screening and monitoring for breast cancer may be advisable for women undergoing repeated IVF cycles.
The Role of Salivary Biomarkers in the Early Detection and Prognosis of Oral Squamous Cell Carcinoma
Authors: Kedia Sameer , Wasu Prashant , Wankhade Shruti , Wasu Shilpa , Patil Punam , Dehenkar Manisha 
Published: November 2024

ABSTRACT

Background:
Oral squamous cell carcinoma (OSCC) is a prevalent and aggressive form of cancer with a high-mortality rate. Early detection and prognosis are critical for improving patient outcomes. Salivary biomarkers have emerged as noninvasive and promising tools for the early detection and monitoring of OSCC. This study aims to evaluate the role of specific salivary biomarkers in the early detection and prognosis of OSCC.

Materials and Methods:
A total of 100 participants were recruited for this study, including 50 patients diagnosed with OSCC and 50 healthy controls. Saliva samples were collected from all the participants and analyzed for the presence and concentration of specific biomarkers, including cytokines, DNA methylation patterns, and microRNAs. Enzyme-linked immunosorbent assay, polymerase chain reaction, and next-generation sequencing were employed to quantify and identify the biomarkers.

Results:
The study found that the levels of specific salivary biomarkers, such as interleukin-6 (IL-6), microRNA-21 (miRNA-21), and hypermethylation of the p16 gene, were significantly elevated in OSCC patients compared to healthy controls. The mean concentration of IL-6 in OSCC patients was 45.3 pg/mL, whereas in healthy controls, it was 12.7 pg/mL. Similarly, miR-21 levels were 3.5-fold higher and p16 hypermethylation was observed in 70% of OSCC patients compared to 10% in the control group. The sensitivity and specificity of these biomarkers for OSCC detection were 85% and 90%, respectively.

Conclusion:
Salivary biomarkers such as IL-6, miR-21, and p16 hypermethylation demonstrate significant potential in the early detection and prognosis of OSCC. These noninvasive biomarkers can aid in the timely diagnosis and management of OSCC, improving patient outcomes and survival rates. Further large-scale studies are warranted to validate these findings and integrate salivary biomarker testing into routine clinical practice.
Comparative Study of Red Blood Cell Parameters in Different Hemoglobinopathies Diagnosed by HPLC at a Tertiary Care Hospital, Rajkot, Gujarat
Authors: Tilva Khushbu K. , Jethwani Deepa , Shah Payal , Dhruva Gauravi A. 
Published: November 2024

Background:
Inherited disorders of hemoglobin (hemoglobinopathies) are the most common genetic disorders in the world with 7% prevalence. Thalassemia and sickle cell anemia are the most prevalent hemoglobinopathies in India. Screening and diagnosis of hemoglobinopathies require a comprehensive evaluation combining clinical and family history, blood counts, red blood cell indices, and molecular analysis.

Aims and Objective:
(1) To differentiate the type of hemoglobinopathies on the basis of red cell parameters, (2) to assess the spectrum of hemoglobinopathies, and (3) to study the age at diagnosis and genderwise distribution of various hemoglobinopathies.

Material and Methods:
A prospective observational study over a period of 1 year (August 2020 to July 2021) at a tertiary care hospital, Rajkot, Gujarat. All indoor patients’ samples were sent for complete blood count (CBC), peripheral smear examination, reticulocyte count, sickling test, and high-performance liquid chromatography (HPLC).

Result:
A total of 140 subjects were included in the final analysis. The mean age at diagnosis was 24.7 ± 10.5 years; 48 participants were male, and the remaining 92 were female with an M:F ratio of 0.5:1. The most common hemoglobinopathy in this study was sickle cell trait (40 cases, 28.6%).

Conclusion:
To reduce the burden of various hemoglobinopathies, screening is recommended as a part of antenatal checkup and in infants after 6 months of age in high-prevalence districts for particular hemoglobinopathies via CBC including RBC indices and HPLC.
Effect of Preferential Relaxing Music on Exercise-Induced Changes in Autonomic Function of the Heart
Authors: Tolani Priyal H. , Phatak Mrunal Suresh 
Published: November 2024

Context:
Music has been used for healing purposes since ancient times. Music therapy is a growing branch which can facilitate and promote a healthy mind and body. Autonomic nervous system (ANS) may serve as one path by which music exerts its therapeutic effects. Interaction between the ANS and cardiovascular system during exercise can be of prognostic importance in many cardiovascular diseases. The measurement of the effects of musical auditory stimulation, using non-invasive test of heart rate variability (HRV), on cardiac auditory response while under stressful condition, like exercise, would help understand the usability of musical interventions in prevention and treatment of cardiovascular diseases.

Aim:
To gauge the effects of preferential relaxing music on exercise-induced changes in frequency domain parameters (LF, low frequency; HF, high frequency; LF: HF ratio) of HRV.

Setting and Design:
Experimental study design.

Methods and Materials:
Sample size—52 healthy young adult volunteers (18–25 years). HRV was measured from the ECG obtained at rest, while listening to preferential relaxing music, after doing moderate exercise and after doing moderate exercise while listening to preferential relaxing music.

Statistical Analysis Used:
Comparison of frequency domain HRV variables was done using paired t-test.

Results:
Non-significant increase in HF component (P value = 0.3) and non-significant decrease in LF: HF ratio (P value = 0.06) after doing moderate exercise with music when compared with after doing moderate exercise without music was observed.

Conclusion:
Preferential relaxing music attenuated exercise-induced decrease in parasympathetic activity post-exercise.
Vietnamese Migrants in Modern Russia: Resettlement, Institutions and Social Boundaries
Authors: Avdashkin Andrey A. 
Published: November 2024

In the post-Soviet period, migrants from Asian countries were unevenly distributed across Russian regions, which influenced the emergence of ethnic markets in the 1990s. In order to advance the field of migration and border studies, it is important to understand why communities of Vietnamese rather than Chinese or Central Asian migrants have formed in some cities. The presence of migrants suggested designating certain places with ethnic terms, etc. The paper is intended to answer the following questions: what is the geography of the settlement of migrants from Vietnam, in what cities and why exactly were Vietnamese markets formed and what migration institutions arose thanks to them. The archival documents from the post-Soviet era, and the results of the Autor’s field work in Magnitogorsk, Orenburg and Ufa made the source base for the research. The materials collected in Moscow, Chelyabinsk and Yekaterinburg provided great assistance. The methodological basis of the manuscript is the theory of mobility. Vietnamese communities were formed by migrants who did not leave Russian cities after 1991. The Vietnamese in these cities were engaged in commercial entrepreneurship, established Vietnamese markets and social infrastructure, invited compatriots through these institutions, and provided various kinds of support to “their own” people. However, the economic instability in Russia led to the immobility of the Vietnamese, both intentionally or involuntarily, which had a profound impact on the geography of the Vietnamese settlement in Russia and the ways of organizing social ties.
Eugenio Trías: el filósofo, el intelectual y el poder
Authors: IBÁÑEZ FANÉS Jordi 
Published: November 2024

La relación más clara y directa de Eugenio Trías con la política fue su actividad como comentarista de la política catalana, española e internacional en los diarios El País, El Mundo y ABC sucesivamente. En este artículo nos proponemos reflexionar sobre su producción en este ámbito entre los años 1994-2004, teniendo en cuenta la intensidad política de esta década no sólo en España (el fin de los años de González, las dos legislaturas de Aznar y el regreso socialista al poder), sino también en el mundo (ataques de septiembre de 2001 en Estados Unidos, invasión de Irak en marzo de 2003, atentados en Madrid en marzo de 2004). Trías nos ofrece un estudio de caso singular y a la vez representativo de las relaciones entre los medios (prensa en papel), la política, la intelectualidad y el poder en España. Su periodismo y posiciones políticas poco o nada tienen que ver con su filosofía, sino es para trivializarla. Pero es interesante de ver cómo el filósofo se resiste a ser tomado por un intelectual, ocultando esta condición bajo la figura del profeta e incluso del partisano.
Palabras clave: Eugenio Trías, Periodismo, Intelectuales, España, Poder.
Family Quality of Life and Psychological Health Factors among Parents with Intellectually Disable Children; The Influence of Parenting Self-efficacy
Authors: Naz Sumaira , Noor Farukh 
Published: November 2024

Parents have to face obstacles in handling the challenging behaviors linked to the children with intellectual disability (ID) while a lack of understanding regarding ID limits their capacity to deliver ongoing care and assistance for these children's physical, emotional, psychological, and social growth. This insufficient knowledge of parents among ID children also influence their own pyschological health negatively which ultimately leads them towards low family quality of life. This situation is being worsened day by day in the world generally and in Pakistan particularly wherein overall 371,834 children bear different types of disabilities including intellectual disability (31,915) while majority of researches in Pakistan focuses on other disorders and a few researches are done on intellectual disability. Thus, this study was designed to determine the family quality of life and psychological health factors among parents with intellectually disabled children as well as the influence of parenting self-efficacy. For this purpose, primary data of 306 parents of intellectually disabled children (7-18 years old) was collected from 4 special education schools and one children’s hospital, Multan and Bahawalpur (Southern-Punjab) Pakistan. The collected data was analyzed in SmartPLS through PLS (SEM) technique. PLS (SEM) results show that psychological distress has large, negative and significant impact on family quality of life and parenting self-efficacy while parenting self–efficacy has large, positive and significant impact on family quality of life. Additionally, parenting self-efficacy significantly fully mediate the relationship between psychological distress and family quality of life. Findings of this study emphasize to draw the attention of parents, teachers, special education departments, policy makers and healthcare providers towards social, psychological, physical, educational and financial issues among the parents of intellectually disabled children for taking immediate supporting measures.
Особенности влияния современных технологий на управленческую деятельность в Российской Федерации
Authors: Р.Р. Хохлов , В.Г. Погосян , Н.В. Павлов 
Published: November 2024

Статья посвящена анализу влияния современных технологий на различные государственные отрасли в Российской Федерации, в частности на управленческую деятельность. Представлены примеры из научных работ авторов, исследовавших вопросы взаимодействия, внедрения и использования современных информационно-коммуникационных технологий и иных инноваций в Российской Федерации в разные года. Указаны основные аспекты, принципы и подходы управленческой деятельности в современной России с целью большего ознакомления читателя с материалом. Представлена информация касательно нынешнего уровня развития технологий в России с указанием тенденций развития новейших технологий. Предоставлена информация о выделенных бюджетных средствах на обучение сотрудников государственных и муниципальных органов работе с современными технологиями, опираясь на федеральный закон. Указана информация об общем бюджетировании развития IT-технологий с 2017 по 2020 г. Выделены практические рекомендации по эффективному внедрению современных технологий в области управленческой деятельности Российской Федерации.
The article is devoted to the analysis of the influence of modern technologies on various public sectors in the Russian Federation, in particular on management activities. Examples from scientific works of the authors who studied the issues of interaction, implementation and use of modern information and communication technologies and other innovations in the Russian Federation in different years are presented. The main aspects, principles and approaches of management activities in modern Russia are indicated in order to better familiarize the reader with the material. Information is provided regarding the current level of technology development in Russia, indicating the trends in the development of new technologies. Information is provided on the allocated budget funds for training employees of state and municipal bodies to work with modern technologies, based on the federal law. Information is provided on the general budgeting for the development of IT technologies for the period from 2017 to 2020. Practical recommendations for a simpler and more effective implementation and use of modern technologies in the field of management activities of the Russian Federation are highlighted.