bluuebunny/crossref_metadata_2025_split huggingface dataset:
Transdiagnostic vs. disorder-focused perspective in children and adolescents with eating disorders: Findings from a large multisite exploratory study
Authors: Curzio O. , Maestro S. , Rossi G. , Calderoni S. , Giombini L. , Scardigli S. , Ragione L. Dalla , Muratori F. 
Published: February 2018

AbstractBackgroundThe transdiagnostic model of eating disorders (ED) proposes common cognitive mechanisms in patients with ED psychopathology. Little is known about their role in the maintenance of ED in children and adolescents. This study aimed to determine whether the relationships between key factors (low self-esteem, weight and shape control, clinical perfectionism, interpersonal problems, distress and mood instability) and core maintaining mechanisms (binge-eating and restraint) would support a transdiagnostic theory in young patients.MethodsA total of 419 patients (mean age 14.7 ± 2.14 years; age range: 7–18 years; males 13.8%) diagnosed with an ED were assessed in six Italian clinical centers in 2013. Multiple comparisons between ED diagnosis, correlation analysis and principal component analysis (PCA) were performed.ResultsOf the entire collective, 51.5% of patients were diagnosed with Anorexia Nervosa (AN), 12.3% were diagnosed with Bulimia Nervosa (BN) and 36.2% with Eating Disorder Not Otherwise Specified (EDNOS). In PCA, the core ED mechanisms, dietary restraint and binge eating, acted as poles of attraction of the other variables. The AN group was particularly linked to restraint and the BN group was particularly related to “Bulimia”. Considering the diagnostic subtypes, there were no significant differences between the anorexic binge-purging group, bulimic purging group and bulimic non-purging group, which constituted a unique cluster related to affective, interpersonal problems and to perfectionism, indicating a very homogeneous subgroup. Restricting anorexic group (AN-R), related to shape concern and anxious-depressed mood, was not linked to the other subtypes. EDNOS appeared to be opposed to the AN-R group; the binge eating disorder group appeared to be independent from others.ConclusionOur results suggest the presence of both specific and transdiagnostic mechanisms in ED subtypes, whose knowledge is of relevance for clinical practice.
Coupling of high Knudsen number and non-ideal gas effects in microporous media
Authors: Wang Ziyan , Wang Moran , Chen Shiyi 
Published: February 2018

High Knudsen number non-ideal gas flows in porous media are important and fundamental in various applications including shale gas exploitation and carbon dioxide sequestration. Because of the small pore size in tight rocks, the Knudsen number (Kn) may be high (i.e. much higher than 0.01) even though the gas is really dense. In fact, due to the high pressure and temperature underground, the gas usually manifests a strong non-ideal gas effect. Understanding the coupling mechanism of the high Kn effect and non-ideal gas effect is a premise to accurately model deep-seated underground gas exploitation or carbon dioxide sequestration. In this work, we theoretically analyse the high Kn non-ideal gas flows in microporous media. Based on the relative importance of the non-ideal gas effect and high Kn effect, the coupling is divided into four types. The analysis is subsequently validated by multiscale numerical simulations, in which the four types of coupling are clearly demonstrated. After applying the analysis to laboratory measurements, we propose a characteristic pressure model to calculate the gas permeability of tight rocks with better precision. The new model incorporates the non-ideal gas effect with the high Kn effect accurately and better bridges the laboratory measurements with the reservoir engineering.
DISTORTION IN THE FINITE DETERMINATION RESULT FOR EMBEDDINGS OF LOCALLY FINITE METRIC SPACES INTO BANACH SPACES
Authors: OSTROVSKA S. , OSTROVSKII M. I. 
Published: February 2018

AbstractGiven a Banach spaceXand a real number α ≥ 1, we write: (1)D(X) ≤ α if, for any locally finite metric spaceA, all finite subsets of which admit bilipschitz embeddings intoXwith distortions ≤C, the spaceAitself admits a bilipschitz embedding intoXwith distortion ≤ α ⋅C; (2)D(X) = α+if, for every ϵ > 0, the conditionD(X) ≤ α + ϵ holds, whileD(X) ≤ α does not; (3)D(X) ≤ α+ifD(X) = α+orD(X) ≤ α. It is known thatD(X) is bounded by a universal constant, but the available estimates for this constant are rather large. The following results have been proved in this work: (1)D((⊕n=1∞Xn)p) ≤ 1+for every nested family of finite-dimensional Banach spaces {Xn}n=1∞and every 1 ≤p≤ ∞. (2)D((⊕n=1∞ℓ∞n)p) = 1+for 1 <p< ∞. (3)D(X) ≤ 4+for every Banach spaceXwith no nontrivial cotype. Statement (3) is a strengthening of the Baudier–Lancien result (2008).
Relevant patient characteristics for guiding tailored integrated diabetes primary care: a systematic review
Authors: Hertroijs Dorijn F.L. , Elissen Arianne M.J. , Brouwers Martijn C.G.J. , Schaper Nicolaas C. , Ruwaard Dirk 
Published: February 2018

AimTo identify which patient-related effect modifiers influence the outcomes of integrated care programs for type 2 diabetes in primary care.BackgroundIntegrated care is a widespread management strategy for the treatment of type 2 diabetes. However, most integrated care programs are not tailored to patients’ needs, preferences and abilities. There is increasing consensus that such a patient-centered approach could improve the management of type 2 diabetes. Thus far, it remains unclear which patient-related effect modifiers should guide such an approach.MethodsPubMed, CINAHL and EMBASE were searched for empirical studies published after 1998. A systematic literature review was conducted according to the PRISMA guidelines.FindingsIn total, 23 out of 1015 studies were included. A total of 21 studies measured the effects of integrated diabetes care programs on hemoglobin A1c (HbA1c) and three on low-density lipoprotein cholesterol, systolic blood pressure and health-care utilization. In total, 49 patient characteristics were assessed as potential effect modifiers with HbA1c as an outcome, of which 46 were person or health-related and only three were context-related. Younger age, insulin therapy and longer disease duration were associated with higher HbA1c levels in cross-sectional and longitudinal studies. Higher baseline HbA1c was associated with higher HbA1c at follow-up in longitudinal studies. Information on context- and person-related characteristics was limited, but is necessary to help identify the care needs of individual patients and implement an effective integrated type 2 diabetes tailored care program.
Notch1 is a prognostic factor that is distinctly activated in the classical and proneural subtype of glioblastoma and that promotes glioma cell survival via the NF-κB(p65) pathway
Authors: Hai Long , Zhang Chen , Li Tao , Zhou Xingchen , Liu Bo , Li Shuai , Zhu Meng , Lin Yu , Yu Shengping , Zhang Kai , Ren Bingcheng , Ming Haolang , Huang Yubao , Chen Lei , Zhao Pengfei , Zhou Hua , Jiang Tao , Yang Xuejun 
Published: February 2018

AbstractGlioblastomas (GBMs) are the most prevalent and devastating primary intracranial malignancies and have extensive heterogeneity. Notch1 signaling is a more complex process in the development of numerous cell and tissue types, including gliomagenesis and progression, and is upregulated in glioma-initiating cells. However, the contradictory expression of Notch1 among lower grade gliomas and GBMs confounds our understanding of GBM biology and has made identifying effective therapies difficult. In this study, we validated that Notch1 and NF-κB(p65) are highly expressed in the classical and proneural subtypes of GBM using the data set from The Cancer Genome Atlas (TCGA) and the Chinese Glioma Genome Atlas (CGGA). DAPT and shRNA targeting Notch1 decreased NF-κB(p65) expression, suppressed cell proliferation, and induced apoptosis of GBM cells in vitro and in vivo. Furthermore, we illustrated that the intracellular Notch could bind with NF-κB(p65) in GBM cells. These findings suggest that the cross-talk between Notch1 signaling and NF-κB(p65) could contribute to the proliferation and apoptosis of glioma, and this discovery could help drive the design of more effective therapies in Notch1-targeted clinical trials.
Reversible chromism of spiropyran in the cavity of a flexible coordination cage
Authors: Samanta Dipak , Galaktionova Daria , Gemen Julius , Shimon Linda J. W. , Diskin-Posner Yael , Avram Liat , Král Petr , Klajn Rafal 
Published: February 2018

AbstractConfining molecules to volumes only slightly larger than the molecules themselves can profoundly alter their properties. Molecular switches—entities that can be toggled between two or more forms upon exposure to an external stimulus—often require conformational freedom to isomerize. Therefore, placing these switches in confined spaces can render them non-operational. To preserve the switchability of these species under confinement, we work with a water-soluble coordination cage that is flexible enough to adapt its shape to the conformation of the encapsulated guest. We show that owing to its flexibility, the cage is not only capable of accommodating—and solubilizing in water—several light-responsive spiropyran-based molecular switches, but, more importantly, it also provides an environment suitable for the efficient, reversible photoisomerization of the bound guests. Our findings pave the way towards studying various molecular switching processes in confined environments.
Resonance Raman signature of intertube excitons in compositionally-defined carbon nanotube bundles
Authors: Simpson Jeffrey R. , Roslyak Oleksiy , Duque Juan G. , Hároz Erik H. , Crochet Jared J. , Telg Hagen , Piryatinski Andrei , Walker Angela R. Hight , Doorn Stephen K. 
Published: February 2018

AbstractElectronic interactions in low-dimensional nanomaterial heterostructures can lead to novel optical responses arising from exciton delocalization over the constituent materials. Similar phenomena have been suggested to arise between closely interacting semiconducting carbon nanotubes of identical structure. Such behavior in carbon nanotubes has potential to generate new exciton physics, impact exciton transport mechanisms in nanotube networks, and place nanotubes as one-dimensional models for such behaviors in systems of higher dimensionality. Here we use resonance Raman spectroscopy to probe intertube interactions in (6,5) chirality-enriched bundles. Raman excitation profiles for the radial breathing mode and G-mode display a previously unobserved sharp resonance feature. We show the feature is evidence for creation of intertube excitons and is identified as a Fano resonance arising from the interaction between intratube and intertube excitons. The universality of the model suggests that similar Raman excitation profile features may be observed for interlayer exciton resonances in 2D multilayered systems.
Absence of warmth permits epigenetic memory of winter in Arabidopsis
Authors: Hepworth Jo , Antoniou-Kourounioti Rea L. , Bloomer Rebecca H. , Selga Catja , Berggren Kristina , Cox Deborah , Collier Harris Barley R. , Irwin Judith A. , Holm Svante , Säll Torbjörn , Howard Martin , Dean Caroline 
Published: February 2018

AbstractPlants integrate widely fluctuating temperatures to monitor seasonal progression. Here, we investigate the temperature signals in field conditions that result in vernalisation, the mechanism by which flowering is aligned with spring. We find that multiple, distinct aspects of the temperature profile contribute to vernalisation. In autumn, transient cold temperatures promote transcriptional shutdown of Arabidopsis FLOWERING LOCUS C (FLC), independently of factors conferring epigenetic memory. As winter continues, expression of VERNALIZATION INSENSITIVE3 (VIN3), a factor needed for epigenetic silencing, is upregulated by at least two independent thermosensory processes. One integrates long-term cold temperatures, while the other requires the absence of daily temperatures above 15 °C. The lack of spikes of high temperature, not just prolonged cold, is thus the major driver for vernalisation. Monitoring of peak daily temperature is an effective mechanism to judge seasonal progression, but is likely to have deleterious consequences for vernalisation as the climate becomes more variable.
Atomic-state diagnostics and optimization in cold-atom experiments
Authors: Sycz Krystian , Wojciechowski Adam M. , Gawlik Wojciech 
Published: February 2018

AbstractWe report on the creation, observation and optimization of superposition states of cold atoms. In our experiments, rubidium atoms are prepared in a magneto-optical trap and later, after switching off the trapping fields, Faraday rotation of a weak probe beam is used to characterize atomic states prepared by application of appropriate light pulses and external magnetic fields. We discuss the signatures of polarization and alignment of atomic spin states and identify main factors responsible for deterioration of the atomic number and their coherence and present means for their optimization, like relaxation in the dark with the strobed probing. These results may be used for controlled preparation of cold atom samples and in situ magnetometry of static and transient fields.
Identification of microRNAs differentially expressed in glioblastoma stem-like cells and their association with patient survival
Authors: Sana Jiri , Busek Petr , Fadrus Pavel , Besse Andrej , Radova Lenka , Vecera Marek , Reguli Stefan , Stollinova Sromova Lucie , Hilser Marek , Lipina Radim , Lakomy Radek , Kren Leos , Smrcka Martin , Sedo Aleksi , Slaby Ondrej 
Published: February 2018

AbstractGlioblastoma stem-like cells (GSCs) are critical for the aggressiveness and progression of glioblastoma (GBM) and contribute to its resistance to adjuvant treatment. MicroRNAs (miRNAs) are small, non-coding RNAs controlling gene expression at the post-transcriptional level, which are known to be important regulators of the stem-like features. Moreover, miRNAs have been previously proved to be promising diagnostic biomarkers in several cancers including GBM. Using global expression analysis of miRNAs in 10 paired in-vitro as well as in-vivo characterized primary GSC and non-stem glioblastoma cultures, we identified a miRNA signature associated with the stem-like phenotype in GBM. 51 most deregulated miRNAs classified the cell cultures into GSC and non-stem cell clusters and identified a subgroup of GSC cultures with more pronounced stem-cell characteristics. The importance of the identified miRNA signature was further supported by demonstrating that a Risk Score based on the expression of seven miRNAs overexpressed in GSC predicted overall survival in GBM patients in the TCGA dataset independently of the IDH1 status. In summary, we identified miRNAs differentially expressed in GSCs and described their association with GBM patient survival. We propose that these miRNAs participate on GSC features and could represent helpful prognostic markers and potential therapeutic targets in GBM.
Highly flexible transparent electrodes based on mesh-patterned rigid indium tin oxide
Authors: Sakamoto Kosuke , Kuwae Hiroyuki , Kobayashi Naofumi , Nobori Atsuki , Shoji Shuichi , Mizuno Jun 
Published: February 2018

AbstractWe developed highly bendable transparent indium tin oxide (ITO) electrodes with a mesh pattern for use in flexible electronic devices. The mesh patterns lowered tensile stress and hindered propagation of cracks. Simulations using the finite element method confirmed that the mesh patterns decreased tensile stress by over 10% because of the escaped strain to the flexible film when the electrodes were bent. The proposed patterned ITO electrodes were simply fabricated by photolithography and wet etching. The resistance increase ratio of a mesh-patterned ITO electrode after bending 1000 times was at least two orders of magnitude lower than that of a planar ITO electrode. In addition, crack propagation was stopped by the mesh pattern of the patterned ITO electrode. A mesh-patterned ITO electrode was used in a liquid-based organic light-emitting diode (OLED). The OLED displayed the same current density-voltage-luminance (J-V-L) curves before and after bending 100 times. These results indicate that the developed mesh-patterned ITO electrodes are attractive for use in flexible electronic devices.
Quantitative Morphometry for Osteochondral Tissues Using Second Harmonic Generation Microscopy and Image Texture Information
Authors: Saitou Takashi , Kiyomatsu Hiroshi , Imamura Takeshi 
Published: February 2018

AbstractOsteoarthritis (OA) is a chronic joint disorder involving degeneration of articular cartilage and subchondral bone in joints. We previously established a second harmonic generation (SHG) imaging technique for evaluating degenerative changes to articular cartilage in an OA mouse model. SHG imaging, an optical label-free technique, enabled observation of collagen fibrils, and characterized critical changes in the collagenous patterns of the joints. However, it still remains to be determined how morphological changes in the organization of tissue collagen fibrils should be quantified. In this study, we addressed this issue by employing an approach based on texture analysis. Image texture analysis using the gray level co-occurrence matrix was explored to extract image features. We investigated an image patch-based strategy, in which texture features were extracted on individual patches derived from original images to capture local structural patterns in them. We verified that this analysis enables discrimination of cartilaginous and osseous tissues in mouse joints. Moreover, we applied this method to OA cartilage pathology assessment, and observed improvements in the performance results compared with those obtained using an existing feature descriptor. The proposed approach can be applied to a wide range of conditions associated with collagen remodeling and diseases of cartilage and bone.
Altered aspects of anxiety-related behavior in kisspeptin receptor-deleted male mice
Authors: Delmas Sarah , Porteous Robert , Bergin Dave H. , Herbison Allan E. 
Published: February 2018

AbstractThe roles of kisspeptin signaling outside the hypothalamus in the brain are unknown. We examined here the impact of Kiss1r-deletion on hippocampus-related behaviors of anxiety and spatial learning in adult male mice using two mouse models. In the first, global Kiss1r-null and control mice were gonadectomized (GDX KISS1R-KO). In the second, KISS1R signalling was rescued selectively in gonadotropin-releasing hormone neurons to generate Kiss1r-null mice with normal testosterone levels (intact KISS1R-KO). Intact KISS1R-KO rescue mice were found to spend twice as much time in the open arms of the elevated plus maze (EPM) compared to controls (P < 0.01). GDX KISS1R-KO mice showed a similar but less pronounced trend. No differences were detected between intact KISS1R-KO mice and controls in the open field test (OFT), although a marked reduction in time spent in the centre quadrant was observed for all GDX mice (P < 0.001). No effects of KISS1R deletion or gonadectomy were detected in the Morris water maze. These observations demonstrate that KISS1R signalling impacts upon anxiogenic neural circuits operative in the EPM, while gonadal steroids appear important for anxiety behaviour observed in the OFT. The potential anxiogenic role of kisspeptin may need to be considered in the development of kisspeptin analogs for the clinic.
Cognition, emotion and reward networks associated with sex differences for romantic appraisals
Authors: Yin Jie , Zou Zhiling , Song Hongwen , Zhang Zhuo , Yang Bo , Huang Xiting 
Published: February 2018

AbstractRomantic love is a cross-culturally universal phenomenon that serves as a commitment device for motivating pair bonding in human beings. Women and men may experience different feelings when viewing the same warm, romantic scenes. To determine which brain systems may be involved in romance perception and examine possible sex differences, we scanned 16 women and 16 men who were intensely in love, using functional MRI. Participants were required to rate the romance level of 60 pictures showing romantic events that may frequently occur during romantic relationship formation. The results showed that greater brain activation was found for men in the insula, PCC (posterior cingulate cortex), and prefrontal gyrus compared with women, primarily under the High-romance condition. In addition, enhanced functional connectivity between the brain regions involved in the High-romance condition in contrast to the Low-romance condition was only found for men. These data suggest that men and women differ in the processing of romantic information and that it may be more effortful for men to perceive and evaluate romance degree.
Jasmonic acid ameliorates alkaline stress by improving growth performance, ascorbate glutathione cycle and glyoxylase system in maize seedlings
Authors: Mir Mudaser Ahmad , John Riffat , Alyemeni Mohammed Nasser , Alam Pravej , Ahmad Parvaiz 
Published: February 2018

AbstractEnvironmental pollution by alkaline salts, such as Na2CO3, is a permanent problem in agriculture. Here, we examined the putative role of jasmonic acid (JA) in improving Na2CO3-stress tolerance in maize seedlings. Pretreatment of maize seedlings with JA was found to significantly mitigate the toxic effects of excessive Na2CO3 on photosynthesis- and plant growth-related parameters. The JA-induced improved tolerance could be attributed to decreased Na uptake and Na2CO3-induced oxidative damage by lowering the accumulation of reactive oxygen species and malondialdehyde. JA counteracted the salt-induced increase in proline and glutathione content, and significantly improved ascorbic acid content and redox status. The major antioxidant enzyme activities were largely stimulated by JA pretreatment in maize plants exposed to excessive alkaline salts. Additionally, increased activities of glyoxalases I and II were correlated with reduced levels of methylglyoxal in JA-pretreated alkaline-stressed maize plants. These results indicated that modifying the endogenous Na+ and K+ contents by JA pretreatment improved alkaline tolerance in maize plants by inhibiting Na uptake and regulating the antioxidant and glyoxalase systems, thereby demonstrating the important role of JA in mitigating heavy metal toxicity. Our findings may be useful in the development of alkali stress tolerant crops by genetic engineering of JA biosynthesis.
The wavelength of the incident light determines the primary charge separation pathway in Photosystem II
Authors: Pavlou Andrea , Jacques Julien , Ahmadova Nigar , Mamedov Fikret , Styring Stenbjörn 
Published: February 2018

AbstractCharge separation is a key component of the reactions cascade of photosynthesis, by which solar energy is converted to chemical energy. From this photochemical reaction, two radicals of opposite charge are formed, a highly reducing anion and a highly oxidising cation. We have previously proposed that the cation after far-red light excitation is located on a component different from PD1, which is the location of the primary electron hole after visible light excitation. Here, we attempt to provide further insight into the location of the primary charge separation upon far-red light excitation of PS II, using the EPR signal of the spin polarized 3P680 as a probe. We demonstrate that, under far-red light illumination, the spin polarized 3P680 is not formed, despite the primary charge separation still occurring at these conditions. We propose that this is because under far-red light excitation, the primary electron hole is localized on ChlD1, rather than on PD1. The fact that identical samples have demonstrated charge separation upon both far-red and visible light excitation supports our hypothesis that two pathways for primary charge separation exist in parallel in PS II reaction centres. These pathways are excited and activated dependent of the wavelength applied.