bluuebunny/crossref_metadata_2025_split huggingface dataset:
Functional testing of a human PBX3 variant in zebrafish reveals a potential modifier role in congenital heart defects
Authors: Farr Gist H. , Imani Kimia , Pouv Darren , Maves Lisa 
Published: October 2018

ABSTRACT
Whole-genome and exome sequencing efforts are increasingly identifying candidate genetic variants associated with human disease. However, predicting and testing the pathogenicity of a genetic variant remains challenging. Genome editing allows for the rigorous functional testing of human genetic variants in animal models. Congenital heart defects (CHDs) are a prominent example of a human disorder with complex genetics. An inherited sequence variant in the human PBX3 gene (PBX3 p.A136V) has previously been shown to be enriched in a CHD patient cohort, indicating that the PBX3 p.A136V variant could be a modifier allele for CHDs. Pbx genes encode three-amino-acid loop extension (TALE)-class homeodomain-containing DNA-binding proteins with diverse roles in development and disease, and are required for heart development in mouse and zebrafish. Here, we used CRISPR-Cas9 genome editing to directly test whether this Pbx gene variant acts as a genetic modifier in zebrafish heart development. We used a single-stranded oligodeoxynucleotide to precisely introduce the human PBX3 p.A136V variant in the homologous zebrafish pbx4 gene (pbx4 p.A131V). We observed that zebrafish that are homozygous for pbx4 p.A131V are viable as adults. However, the pbx4 p.A131V variant enhances the embryonic cardiac morphogenesis phenotype caused by loss of the known cardiac specification factor, Hand2. Our study is the first example of using precision genome editing in zebrafish to demonstrate a function for a human disease-associated single nucleotide variant of unknown significance. Our work underscores the importance of testing the roles of inherited variants, not just de novo variants, as genetic modifiers of CHDs. Our study provides a novel approach toward advancing our understanding of the complex genetics of CHDs.
Posso ser candidato a Presidente? depende do STF
Authors: Veloso Antônio Rodolfo Franco Mota , Lima Martonio Mont'Alverne Barreto 
Published: October 2018

Analisa a (im)possibilidade de o Judiciário impedir a candidatura de uma pessoa que esteja sendo processada criminalmente em primeira instância ao cargo de Presidente da República. O estudo aufere relevância desde a análise da realidade político-jurídico-econômica nos governos Dilma (2º mandato) e Temer, em que pode ser constatada a intensifi cação do casuísmo nas decisões proferidas pelo Supremo Tribunal Federal (STF), principalmente quando se verifi cam os argumentos expressos nos votos de alguns ministros, podendo ser constatados contrastes entre as decisões, ainda que os casos sejam semelhantes. Em decorrência desses dados, emergem indagações em relação à possibilidade de o Judiciário, com a aplicação de determinados princípios (mais especificamente da moralidade, da presunção de inocência e da legalidade), impedir a candidatura de uma pessoa à Presidência da República, conquanto não esteja essa hipótese de inelegibilidade disposta no ordenamento jurídico. Assim, este trabalho tem como objetivos estudar as decisões do STF que possam infl uenciar futuros pensamentos dos magistrados, bem como debater o modo como os princípios da moralidade, da legalidade e da presunção de inocência são aplicados a essa situação. Para alcançar tais fi nalidades, far-se-á um levantamento da legislação e de julgados do STF que tratem (in)diretamente da inelegibilidade para, no segundo momento, confrontá-las com os referidos princípios, concluindo que a atuação dos ministros do STF enseja preocupação em virtude da ausência de previsibilidade de suas decisões. Por isso, por mais que os autores entendam não ser possível a ampliação do rol de inelegíveis, senão por meio de lei complementar, as fundamentações expressas pelos membros da referida Corte dão base ao receio de que, com base na imprecisa moralidade, pessoas possam ser impedidas de se candidatar a um cargo público.
Taking Needs into Deeds: Application of Needs Analysis in Undergraduate EAP Course Design
Authors: Du Jianying , Shi Jie 
Published: October 2018

AbstractNeeds analysis as the central force of EAP has received insufficient practice, resulting in dissatisfactory pedagogy. This study proposes a framework of CEAPNA (comprehensive EAP needs analysis), and illustrates how the framework helps to shape learning-centered EAP pedagogy. The CEAPNA survey covered 452 undergraduates and 83 faculty members from science and engineering departments, and was triangulated with the researchers’ retrospection of seven years of pedagogical practice. Major findings in the study suggest multiple sources as a must in a comprehensive and accurate analysis of EAP learner needs. In the meantime, the specificity of learner needs addresses EAP practitioners’ endeavors to specify these needs in various dimensions, so as to negotiate a satisfactory balance between language, cognition and affect in EAP pedagogy. Due to realistic constraints in specifying and balancing the needs, this paper wishes to oblige with a conceptual interpretation as well as a pedagogical retrospection.
A Case Study on Intermediate CSL Learners’ Word Recognition Processes and Strategies in Contextual Reading Settings
Authors: Luo Shaoqian , Sun Xiaohui 
Published: October 2018

Abstract
This study investigates word recognition processes and strategies of intermediate learners of Chinese as a Second Language (CSL) in contextual reading settings. Two intermediate CSL learners were chosen as research participants, and think-aloud methods and retrospective interviews were used to collect data. The data were analyzed by using Moustakas’ data analysis procedure, Creswell’s three steps and Bogdon and Biklen’s data analysis methods. Results indicated that intermediate CSL learners go through different processes of word recognition as it might be automatic, based on context, pronunciation, previous knowledge and the meaning of characters, or, in case of word recognition failure, skipping the words or skipping them but reading them again later; and their word recognition strategies in contextual reading settings mainly include cognitive strategies and self-regulatory strategies. Among these strategies, cognitive strategies consist of direct transformation, translation, interpretation, guessing, inferring and finding key words; and self-regulatory strategies include metacognitive strategies, behavior regulating strategies, emotion regulating strategies and motivation regulating strategies. A model of intermediate CSL learners’ word recognition strategies can be constructed based on the results. The present study provides both theoretical and pedagogical implications in the field of CSL vocabulary acquisition and teaching.
The association of hs-CRP and fibrinogen with anthropometric and lipid parameters in non-obese adolescent girls with polycystic ovary syndrome
Authors: Mažibrada Ilijana , Djukić Tatjana , Perović Svetlana , Plješa-Ercegovac Marija , Plavšić Ljiljana , Bojanin Dragana , Bjekić-Macut Jelica , Simić Petar D. , Simić Tatjana , Savić-Radojević Ana , Mastorakos George , Macut Djuro 
Published: October 2018

AbstractBackgroundThe aim of the study was to evaluate high-sensitivity C-reactive protein (hs-CRP) and fibrinogen in non-obese normoinsulinemic adolescent girls with polycystic ovary syndrome (PCOS) and their relationship with anthropometric and lipid parameters.MethodsThe study comprised a total of 26 adolescent girls newly diagnosed with PCOS and 12 healthy controls with regular ovulatory menstrual cycles. The concentration of hs-CRP, fibrinogen, anthropometric measurements, and biochemical and hormonal testing were assessed.ResultsPCOS adolescent girls had significantly higher levels of hs-CRP and fibrinogen compared to healthy controls. In univariate regression analysis, statistically significant associations of hs-CRP and fibrinogen levels of PCOS patients have been shown with body mass index (BMI), waist circumference (WC), hip circumference (HC) and low-density lipoprotein (LDL)/high-density lipoprotein (HDL) ratio, while hs-CRP levels were also associated with cholesterol and LDL. In the multivariate regression model, we found that hs-CRP levels were predicted by BMI (β=0.541, p<0.001) and LDL (β=0.507, p=0.014), while fibrinogen levels were predicted by BMI (β=0.449, p=0.004).ConclusionsWe have shown an association of proinflammatory indices hs-CRP and fibrinogen with anthropometric and lipid parameters of adolescent women with PCOS. The inflammatory markers might be useful in monitoring normal-weight adolescent women with PCOS in an effort to timely prevent unfavorable changes in body mass and lipid profile.
Differences in Strength Performance Between Novice and Elite Athletes: Evidence From Powerlifters
Authors: Latella Christopher , van den Hoek Daniel , Teo Wei-Peng 
Published: October 2018

Abstract
Latella, C, van den Hoek, D, and Teo, WP. Differences in strength performance between novice and elite athletes: Evidence from powerlifters. J Strength Cond Res 33(7S): S103–S112, 2019—Strength forms an integral part of many sports. In particular, powerlifting success is determined solely by maximal strength, providing a unique opportunity to investigate the differences and potential factors influencing novice and elite competitors. We evaluated performance from 2,137 competitors between local (LOC), national (NAT), and international (INT) competitions. Results were analyzed by using the total (TOT) competition score within weight classes and age categories. Cohen's d effect sizes and 95% confidence intervals were used to detect differences within categories between LOC, NAT, and INT competitions. The coefficient of variation (CV) was used to determine the absolute variability. A moderate to large increase in performance was observed for all weight classes between LOC and NAT (men; d = 0.76, women; d = 1.09). No meaningful differences were observed between LOC and NAT, and NAT and INT when compared using age. No meaningful differences were observed between NAT to INT competitions when compared using weight classes. The CV was not different across competition level (CV = 17.4–22.9%) categories. Several internal (athlete) and external (environmental) factors are likely to explain these findings. Therefore, factors such as training experience, performance variability, body composition, anthropometric characteristics, and competition pressure that may influence strength performance should also be considered in both training phases and during competition. Collectively, the results offer novel information regarding the difference in strength performance between novice, subelite, and elite strength athletes. Strength and conditioning professionals should consider these factors when working with various athletes where maximal strength is an important determinant of success.
Metabolic Responses to a Battling Rope Protocol Performed in the Seated or Stance Positions
Authors: Brewer Wayne , Kovacs Reka , Hogan Kasey , Felder Dominisha , Mitchell Hannah 
Published: October 2018

Abstract
Brewer, W, Kovacs, R, Hogan, K, Felder, D, and Mitchell, H. Metabolic responses to a battling rope protocol performed in the seated or stance positions. J Strength Cond Res 32(12): 3319–3325, 2018—The purpose of this study is to compare the levels of oxygen consumption and heart rate responses elicited by a treadmill or cycle

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max test with a standing or sitting battling rope protocol (BRP) (treadmill vs. standing BRP) (cycle vs. seated BRP). Forty healthy subjects performed either a ramped

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max treadmill or cycle test. At least 3 days later, the subjects who performed the ramped treadmill test did the standing BRP, and the subjects who performed the ramped cycle test did the sitting BRP. Each BRP consisted of 10 sets of 15/45 seconds of work/rest for 10 sets.

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peak and HRpeak were recorded. Metabolic responses were significantly lower for the sitting BRP and standing as compared to the HRmax and

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max values derived from the bicycle and treadmill tests. The BRP produced a

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peak that was 71.87% (sitting) and 68.37% (standing) of the subjects'

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max assessed u the bicycle and treadmill protocol. Moderate correlations were found between the

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during the seated (r = 0.61; p = 0.003) and standing (r = 0.43; p = 0.03) BRP and the bicycle and treadmill

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max tests, respectively. The HRpeak elicited by the BRP performed in sitting (r = 0.52; p = 0.009) and standing (r = 0.67; p = 0.001) had a moderate correlation with the HRmax derived from the bicycle and treadmill tests. Battling ropes may be a low cost, accessible option to improve cardiovascular endurance for individuals who cannot stand or move their lower extremities in a rhythmic manner to conduct aerobic exercise.
Az alvás és a kimerültség vizsgálata daganatos betegek körében
Authors: Bollmann Anna Klaudia , Fábián Balázs , Molnár Judit 
Published: October 2018

Abstract: Introduction: The diagnosis of cancer elicits greater distress than any other diagnosis. The prevalence of psychological difficulties is high in cancer, and resources of the medical staff are limited. The development of efficient screening measures is therefore of utmost importance. Sleep is vital to all psychological functioning and poor sleep is a known problem in cancer. Aim: The main goal of the present study was testing of visual analogue scales assessing sleep quality and fatigue. Method: Sleep quality and fatigue were assessed with visual analogue scales. The Sleep Condition Indicator, the Athens Insomnia Scale and the Cancer Fatigue Scale were also included. Psychological distress was assessed with the Generalized Anxiety Disorder Scale, the Beck Depression Inventory and the Brief Difficulties in Emotion Regulation Scale. Pain and well-being was measured with the Faces of Pain Scale and the WHO Well-being Scale, respectively. A total of 71 patients with cancer were enrolled in this study. Results: Insomnia and fatigue – measuring them with visual and several-item scales – showed high correlation with the measures of distress (anxiety, depression, emotion regulation difficulties) and pain. Distress and pain showed significant negative correlation with well-being. Conclusions: It has been affirmed that sleep quality is crucial in the changes of distress, pain and general well-being in cancer patients. It affirms that the visual analogue scales assessing sleep quality and fatigue – besides sleep quality and fatigue – are acceptable screening tools of distress and decreased well-being. Their use in clinical practice is recommended for screening in cancer patients and providing indications for onco-psychological treatment. Orv Hetil. 2018; 159(42): 1720–1726.
Pedagogisk forskning vid Göteborgs universitet 1963 – 1975
Authors: Lundgren Ulf P. 
Published: October 2018

The article is a personal text about pedagogical research and the department of education at the University of Gothenburg in the years 1963 - 1975. In the beginning there was a thin line of demarcation between departments of education and psychology. Only a corridor separated them. The research within education was characterized by studies related to the ongoing reforms of the school system. Several of the studies that carried out gave a scientific base for the education policy. These led to the foundation longitudinal studies.
During the period, the research community changed. Funds for research groups were added and a new doctorate exam was introduced. During the first years of the period, the university was small and there was free access to all study courses. I followed the seminars in General and Comparative Ethnography and Theory of Science. The University was rather small. Towards the end of the period, universities had more than doubled the number of students and it was barely understandable variety of subjects and programs. The departments in psychology and education had different profiles and attracted different student groups.
Initially, research was often an individual project with none or little of financial support. There were no education programs for doctoral students. In the year of 1975 there was a completely different organization for research; with research groups, and doctoral studies was a specific study program.
Finally, my purpose was to describe the growth of the university system – with the University of Gothenburg in focus – during the period 1963 – 1975 in general and how education as science was formed in particular.
Torsio uteri beim Rind: Therapie sowie Verletzungsrisiko für die Kuh und Prognosestellung für das Kalb
Authors: Mair Bettina , Sauter-Louis Carola , Zerbe Holm , Klaus-Halla Daniela 
Published: October 2018

Zusammenfassung
Gegenstand und Ziel: In einer Feldstudie wurden bei Kühen mit Torsio uteri klinische Parameter, Behandlungsmaßnahmen und deren Erfolg erhoben. Ziel war, wichtige Faktoren der Diagnose- und Prognosestellung sowie Konsequenzen für die Therapieentscheidung abzuleiten. Material und Methoden: Unter Praxisbedingungen erfolgte eine systematische Dokumentation von 114 Fällen einer Torsio uteri. Die Tiere wurden unmittelbar vor der Retorsion und unmittelbar post partum (p. p.) untersucht. Ergebnisse: Bei guter Geburtsvorbereitung des Muttertieres lag die Letalität der Kälber bei 14,9 %, bei mangelnder Vorbereitung stieg sie auf 58,3 % (p = 0,006). Überschritt die Erkrankungsdauer 12 Stunden, überlebten lediglich 34,8 % der Kälber, während dieser Anteil bei einer ˂ 6 Stunden und einer 6-12 Stunden bestehenden Torsio uteri 85,7 % bzw. 92,2 % (p ˂ 0,001) betrug. In 82,5 % der Fälle erfolgte die Therapie durch direkte manuelle Retorsion des Uterus mittels Kamer’schem Griff und/oder Hebegriff, in 17,5 % durch die Brettwälzmethode. Hinsichtlich der Letalität der Kälber (4,7 % vs. 18,2 %; p = 0,139) oder dem Verletzungsrisiko für das Muttertier (31,9 % vs. 42,1 %; p = 0,391) ergaben sich keine statistisch signifikanten Unterschiede zwischen den Methoden. Ein zeitlich verzögerter Auszug nach erfolgreicher Retorsion und Abwarten der Aufweitung des Zervixkanals stellt eine Option bei Zervixenge dar, birgt aber ein signifikant höheres Verletzungsrisiko für die Kuh (57,2 %) im Vergleich zum sofortigen Auszug (26,8 %; p = 0,018). Mit steigender Manipulationsdauer nahm auch das Ausmaß an Verletzungen des Muttertieres signifikant zu (p ˂ 0,001). Schlussfolgerung und klinische Relevanz: Die Qualität der Geburtsvorbereitung kann bei der Kuh mit Torsio uteri als prognostischer Faktor für das Überleben des Kalbes herangezogen werden. Unter Praxisbedingungen lässt sich eine Torsio uteri in den meisten Fällen erfolgreich konservativ therapieren. Eine sachgerechte und indikationsbezogene Anwendung der Brettwälzmethode kann empfohlen werden. Eine gute Geburtsüberwachung und frühzeitiges Eingreifen im Falle einer Torsio uteri sind für Krankheitsverlauf und Prognose von entscheidender Bedeutung.
Effects of mares’ age and day of gestation on efficacy of transvaginal ultrasound-guided twin reduction
Authors: Rau Janina , Tiedemann Daniela , Sielhorst Jutta , Tönissen Anna , Burger Dominik , Martinsson Gunilla , Rohn Karl , Oldenhof Harriette , Sieme Harald 
Published: October 2018

Summary
Objective: Transvaginal ultrasound-guided aspiration (TUA) is a procedure which can be used for the reduction of twins post-fixation in the mare. The aim of this study was to evaluate the effect of the age of mares and the day of gestation on the outcome of TUA treatment. Material and methods: In 88 mares, diagnosed pregnant with twins, TUA of the yolk sac or allantoic fluid was performed between day 30 and 62 of gestation. Mares were aged 3–22 years. Ultrasonographic examination for a viable singleton pregnancy was performed by referring veterinarians 5–7 days and 4 weeks after TUA. Based on reported findings, effects of age and day of gestation on pregnancy rates were evaluated. Results: Four weeks after TUA, 67% of the cases resulted in a viable singleton pregnancy. Five to 7 days after TUA treatment, the success rate was 74%. The gestational period did not affect the outcome, irrespective of the age of the mare. In contrast, success rates decreased with increasing age of the mares (84% ≤ 7 years vs. 67% 8–14 years vs. 57% ≥ 15 years). In mares aged 8–14 years, a decrease in singleton pregnancies was observed, if TUA was performed after day 35 of gestation. Success rates were slightly higher, if twin vesicles were localized within separate uterine horns (73%) as compared to the same horn (66%). Differences in singleton pregnancy rates were not statistically significant (p > 0.05). Conclusions and clinical relevance: TUA was found to be an effective procedure for reduction of twin pregnancies performed at days 30–62 of gestation. Success rates for singleton pregnancies were high for young mares ≤ 7 years old (84%) and middle aged mares treated before day 36 of pregnancy (74%). Duration of pregnancy at the time of TUA did not have a major impact on the outcome. Nevertheless, the procedure should optimally be performed around days 32–35 of pregnancy to allow for the possibility of natural reduction before treatment and rebreeding in case of a total pregnancy loss after TUA.