bluuebunny/crossref_metadata_2025_split huggingface dataset:
The efficacy of radiofrequency hyperthermia combined with chemotherapy in the treatment of advanced ovarian cancer
Authors: Li Zhihui , Sun Qinge , Huang Xiaoyan , Zhang Jianzhong , Hao Jing , Li Yue , Zhang Shihong 
Published: June 2018

Abstract
This study investigated the effect of radiofrequency hyperthermia combined with chemotherapy in the treatment of advanced ovarian cancer.

Methods
Seventy-five patients with advanced ovarian cancer were grouped into observation (n = 36) and control (n = 37) groups according to different treatment methods. The age of the patients in the control and the experimental groups were (55 + 11) and (53 + 12) years old, respectively. The control group was received chemotherapy alone (paclitaxel + cisplatin chemotherapy), and on the basis of systemic chemotherapy, the observation group was administered therapy in conjunction with abdominal pelvic radiofrequency hyperthermia.

Results
The tumor remission rate, ascites, serum CA125 levels, pain control, quality of life enhancement, III+IV bone marrow suppression and improvement of gastrointestinal reaction in the observation group were better than those of the control group (all P< 0.05).

Conclusion
Radiofrequency hyperthermia combined with chemotherapy in the treatment of advanced ovarian cancer has significantly improved the tumor remission rate, ascite control and CA125 levels, and substantially reduced the gastrointestinal reaction and bone marrow suppression rate, which is worthy of intensive clinical application.
Norleucine metal complexes: comments on their equilibrium constants data
Authors: Fazary Ahmed E. , Bani-Fwaz Mutasem Z. , Fawy Khaled F. , Sahlabji Taher , Awwad Nasser S. , Abd-Rabboh Hisham S.M. 
Published: June 2018

Abstract
This discussion article summarizes all protonation and stability constants data found in the literature for nonprotein l-norleucine amino acid and its metal complexes. The results of approximately 18 published articles discussing the protonation and complexation equilibria of l-norleucine using different techniques and software were presented to comprehend the data on the grounds of modern aspects of l-norleucine complex chemistry.
The DoloTest® in a specialized headache center among patients receiving psychological treatment. A pilot study
Authors: Nielsen Marianne Kromann , Westergaard Maria Lurenda , Nielsen Dorte Kjeldgaard , Zimmer Trine , Jensen Rigmor Hoejland 
Published: June 2018

Abstract

Background
The DoloTest is a newer health-related quality of life (HRQoL) monitoring instrument for pain, not yet validated for headache.

Aims
To examine the usefulness of the DoloTest in a specialized headache center.

Methods
The sample consisted of patients referred to psychologists from the Danish Headache Center (DHC) for whom the test was carried out at start of, end of, and 6 months after treatment. Points on eight scales of the test were measured (values ranged from 0 to 100), then totaled (0 to 800). Scores were analyzed using Wilcoxon Signed Ranks test. The correlation between headache days and DoloTest scores were computed using linear regression adjusted for age. Qualitative feedback on usefulness of the test were gathered from psychologists.

Results
Of 135 patients included, 105 completed treatment. On average, headache days decreased from 22 days per month at start of treatment (SD 9.0, median 29) to 18 days at end of treatment (SD 10.8, median 19) (p<0.001). At end of treatment, DoloTest scores improved for pain (p=0.015) and reduced energy and strength (p=0.034). At 6 months’ follow-up, total scores improved (p=0.034), as well as component scores for pain (p=0.010), problems with strenuous activity (p=0.045) and reduced energy and strength (p=0.012). Correlation between reduced headache days and improved DoloTest scores was 0.303 (p=0.028). Psychologists found the test useful in monitoring and evaluating patients.

Conclusions
The DoloTest was useful for psychoeducation and for monitoring the effect of headache treatment.

Implications
The DoloTest is a potential HRQoL monitoring instrument for headache patients. We recommend further validation studies.
Formen und Funktionen von Polemik in den Briefen Augustins: Versuch einer Klassifikation
Authors: Tornau Christian 
Published: June 2018

Abstract:
Due to the conventions of late-antique epistolary politeness, it is not always easy to identify polemical passages in Augustine’s correspondence. The present contribution attempts to discern and classify some recurrent techniques and strategies that are characteristic of letters the addressee of which is him- or herself the target of Augustine’s polemics, i. e. in which polemical rhetoric is blended with diplomacy. After describing some more formal techniques, such as polemical hermeneutics and Refraintechnik, I turn to the rhetorical, i. e. persuasive, functions of polemics in Augustine’s anti-pagan, anti-Donatist and anti-Pelagian letters, using the basic distinction between direct polemics (polemics against the addressee in person) and indirect polemics (polemics against the addressee’s group or friends) as a starting point. Another relevant distinction, taken into account throughout, is whether a polemical letter is primarily designed to impress the immediate addressee or to have an effect on the wider readership that Augustine had to reckon with as soon as a letter was dispatched.
Grußformeln als Medium der Polemik in Augustins Briefen
Authors: Nunn Christopher Alexander 
Published: June 2018

Abstract:
The analysis of salutations is often disregarded because they are said to be later additions of copyists or at least conventional phrases without any content. But the correspondence of Augustine suggests that the bishop himself composed the recorded salutations and that he even added a subtext in many cases. The survey sheds light on elements, development, and different functions of salutations in order to show that, at least in Augustine’s correspondence, an analysis of the salutations is a valuable resource to describe not only the social differences between sender and recipient, but also the atmosphere, the reason for writing, and the correspondents’ relationship to each other.
Polemik, Unfreundlichkeit und Invektivität in den Briefen des Hieronymus am Beispiel der jovinianischen Kontroverse
Authors: Schaaf Ingo 
Published: June 2018

Abstract:
Unfriendly modes of communication are integral parts of theological controversy in the Early Church. As some of the most notorious examples in this regard, the works written by Jerome of Stridon offer plentiful features of polemic ranging from relatively subtle forms of unfriendliness to open invective. Particularly well suited for a comparative reading is a group of three letters from Jerome’s pen dating to a time when the Jovinian controversy had reached yet another climactic point. Closely related to one another, since both their recipients count among Jerome’s supporters in Rome, these letters (48, 49, and 50 Hilberg) serve as case studies of epistolary polemic in Late Antiquity inviting comparison with other patristic authors, as well.
Iminiumsalz-Strukturen bei der durch Pyridoxalphosphat (Vitamin B6) katalysierten Bildung von Aromastoffen und Fehlaromen im Wein
Authors: Müller Nikolaus 
Published: June 2018

AbstractEnzymes that use pyridoxal phosphate (PLP, Vitamin B6) as cofactor constitute a ubiquitous class of biocatalysts. A variety of PLP-dependant enzymes mainly involved in biochemical pathways concerning amino acid metabolism are found in all forms of life. These enzymes also play an important role in wine production, as well in grape growing as in enological processes. The formation of pleasant aroma compounds often runs with participation of pyridoxal-dependant enzymes. But these are also brought into context with the formation of off-odors, especially from sulfur compounds (i.e. sulfur containing amino acids cysteine, methionine). The versatility of PLP-dependant bioreactions arises from its ability to covalently bind the substrate and then to function as an electrophilic catalyst, thereby stabilizing different types of carbanionic reaction intermediates, containing iminium salt structures. This article summarizes the influence of PLP on sensorically important aroma compounds in wine growing and wine processing.
Evaluation of Steel Slag Powder as Filler in Hot-Mix Asphalt Mixtures
Authors: Wu Bangwei , Liu Liping , Feng Yanjin 
Published: June 2018

Abstract
Steel slag has been used as an aggregate for asphalt mixtures for many years, but its excessive volume expansion has limited its wide applicability. With the development of steel-making technology, a considerable amount of steel slag powder (SSP) was produced in Shanghai. The objective of this article is to evaluate the feasibility of using SSP as a filler in hot-mix asphalt mixtures (HMAs), with the aim to eliminate the volume expansion of steel slag asphalt mixture while retaining good pavement performance. First, a common AC-13 mixture was designed with limestone aggregate and mineral filler. Then, 25, 50, 75, and 100 % of the limestone mineral filler in the AC-13 was replaced by SSP, according to the volume ratio, respectively. The asphalt content was kept constant in this process. Then the volume expansion property, rutting resistance property, low temperature property, moisture property, and failure property of the asphalt mixtures were checked. According to the test results, the AC-13 that used SSP exhibited negligible volume expansion, while other properties were better than those of the common AC-13, especially the rutting resistance and moisture properties. The test results also showed that the higher the replacement ratio of SSP, the greater the effect on the properties of the asphalt mixtures. Finally, it was concluded that SSP could replace mineral filler in asphalt concrete (AC) with better pavement performances and acceptable volume expansion.
Processamento de estruturas coordenadas com elipse no Português Brasileiro
Authors: Da Silva Andressa Christine Oliveira , Fonseca Aline Alves , De Carvalho Laís Lagreca 
Published: June 2018

Este trabalho investiga o processamento de dois tipos de sentenças coordenadas: (1) estrutura coordenada de objeto (nongapping), Alice assou bolos pras amigas e biscoitos pra sua prima; e (2) estrutura coordenada de sujeito (gapping), Alice assou bolos pras amigas e Camila pra sua prima. Conduzimos três testes: um questionário em que os participantes ranqueavam suas preferências de completação da oração principal “Alice assou bolos para as amigas e...”, e dois testes de self-paced reading em que medimos o tempo de reação à leitura do DP que aparece depois da conjunção “e” e do PP que segue o DP e desfaz uma possível ambiguidade. Esta pesquisa foi inspirada pelos trabalhos de Carlson (2001, 2002), que investigou o processamento dessas estruturas no inglês. Os resultados dos três experimentos sugerem que nem sempre a construção mais simples do ponto de vista estrutural (nongapping) é o input mais simples para o parser.
O que a Neurociência tem a nos dizer (ou ainda não) sobre o processamento da metáfora?
Authors: Forneck Kári Lúcia 
Published: June 2018

As pesquisas com neuroimagem acerca do processamento da metáfora apresentam achados distintos, o que implica dificuldades na formulação de um paradigma teórico de base neurológica da metáfora. Neste estudo, argumentamos que a falta de clareza de aspectos conceituais sobre a metáfora sob uma perspectiva linguística implica diversidades no desenho dos experimentos e incongruências nos achados. Para sustentar esse argumento, apresentamos uma análise qualitativa de um corpus composto por 20 experimentos com neuroimagem acerca do processamento da metáfora sob dois aspectos: os fundamentos conceituais de metáfora e os achados obtidos nos experimentos. Verificamos que a ausência de um diálogo entre Neurociência e Linguística sobre as propriedades da metáfora resulta numa delimitação problemática de um padrão de processamento da metáfora sob um viés neurológico.
Investigating the nexus between Non-Performing Loans in the Nigerian Banking System and Lending to Micro-Small Medium Enterprises
Authors: Akpan Umoren, Aniefiok , Okon Eyo, Emmanuel , Brownson Akpan, Sunday 
Published: June 2018

Micro-Small and Medium Enterprises (MSMEs) constitute vital ingredients for the lubrication of the development process of any economy. Therefore, Micro-Small and Medium Enterprises are bedrocks of emerging economies as they exact vital roles in promoting and sustaining growth and development. However, in Nigeria MSMEs are facing myriad of challenges and difficulties in funding their activities. Rising trends in Non-performing loans (NPLs) adversely affected availability of loans and advances to economic agents in the Nigerian economy thereby constraining financial intermediation and economic activities hence growth. The study investigated the nexus existing between NPLs in the Nigerian banking system and lending to MSMEs sub-sector in Nigeria from 1981-2015. Time series data used in the study were collected from annual statistical bulletin of the Central Bank of Nigeria (CBN). These data were subjected to descriptive and inferential methods. The results of the graphical presentations indicated irregular fluctuations in NPLs. The graphs indicated positive trends in respect to lending to MSMEs and the productivity of MSMEs. The estimated OLS results showed negative nexus between non-performing loans and lending to MSMEs. This negative nexus led to concomitant low MSMEs productivity in Nigeria. The study recommended that CBN should increase its financial surveillance over the sectors and also ensure timely resolutions of the NPLs challenges CBN should increase arrays of financial intervention that would address paucity in funds in the MSMEs sub-sector
The state of conjunctival flora and its susceptibility to “Vitabakt” in cataract patients compared to other antibiotics used in ophthalmologic practice
Authors: Pirogov Yuriy I. , Shustrova Tatyana A. , Oblovatskaya Evgeniya S. , Khromova Ekaterina S. 
Published: June 2018

The problem of increasing microbial antibiotic resistance antimicrobial requires a detailed study of all antimicrobial drugs spectrum of activity. In the available literature, there are no data on microbial flora in vitro susceptibility to picloxydine.
The aim of this study was to study the conjunctival flora composition and its susceptibility to antimicrobial drugs in patients before phacoemulsification, and to detect the conjunctival flora sensitivity to picloxydine in the postoperative period.
Materials and methods. Before phacoemulsification, 117 swabs (116 patients) were taken from the conjunctiva before any drop instil lation. All swabs were examined using the routine cultural method and 14 antibiotics-panel susceptibility testing. Picloxydine susceptibility was tested four times during the postoperative period in 28 patients.
Results. In 66.7%, bacterial growth was obtained preoperatively. All isolates were gram-positive, St. epidermidis was found most frequently (78.8%). In 1 hour after surgery, bacterial growth was obtained in 27.6%. Fluoroquinolones, linezolid, and picloxydine revealed highest efficacy toward St. epidermidis and St. aureus.
Conclusion. Moxifloxacin, linezolid, and picloxydine turned out to be the most effective antimicrobial drugs. Сonjunctival flora was detected in 1 hour after phacoemulsification. Сonjunctival flora remains sensitive to picloxydine during 1 month in the postoperative period.
Some complementary perspectives in understanding the axiological universe of teachers
Authors: Venera-Mihaela Cojocariu 
Published: June 2018

The values in which teachers believe express the philosophy of education to which they adhere. Our study is based on two related dimensions: the study of the specialised literature and the conclusions of some studies that we have conducted in the last 5 years regarding the values in which the teachers at different stages of the Romanian education system believe. Its purpose: to identify significant perspectives for the complementary analysis of the teacherâ€™s axiological universe. We identified, developed and systematised the following perspectives: contemporary world and the dimension of values; initial and continuous teacher training and the issue of values; on axiological self-reflexivity and its effects and the transfer of values and the holistic evolution of the teacher. The conclusions reinforce the teacherâ€™s hypostasis as reflexive practitioner with profound implications, both on the day-to-day performance of the instructive-educational process and on the reconsideration of the coordinates of their initial/continuing training.
Keywords: Values, teacherâ€™s axiological universe, reflexive practitioner.
The administrative factors affecting school effectiveness of municipal schools in Udon Thani Province
Authors: Sroinam Somkid 
Published: June 2018

School effectiveness is a main goal of all schools because it means organisational success that must be achieved. This study explored the level of the administrative factors and school effectiveness including investigated administrative factors effecting the management of school effectiveness. The 5-level rating scale questionnaire was applied for collecting data from 217 teachers in municipal schools in Udon Thani province, Thailand. The descriptive statistics, Pearson product-moment correlation coefficient and stepwise multiple regression analysis were used for data analysis. The research findings indicated that the school culture, technology, school climate and budgeting were the best predictors. This may lead to policy of developing the school administration to achieve the school goals.
Keywords: School effectiveness, school factor, municipal schools.
Interesting textual tasks as creative tools
Authors: Gogovska Valentina 
Published: June 2018

This study aims to promote the use of interesting textual tasks during everyday mathematics classes, especially during solving exercises. Consequently, this should contribute to the possibility for students to obtain long-lasting knowledge while stimulating the process of creative thinking and understanding. Further to encourage students to investigate mathematical concepts on a deeper, more creative level, we use rich and interesting problems that can be explored on a variety of levels. This process should be well planned, though-out and specified. Well-chosen tasks and discussion can not only improve and empower the process of individualisation and differentiation during doing mathematics but also stimulate the process of creative thinking and motivate students in their current learning. These interesting tasks can be solved in a variety of ways and students should be given a chance to explain their reasoning to each other. One interesting task can be used as a springboard for several others.
Keywords: Teaching legal translation, ESP, ESL, error analysis.
Adesão terapêutica em idosos hipertensos: revisão integrativa
Authors: Pinheiro Fernanda Machado , Do Espirito Santo Fatima Helena , De Sousa Renata Miranda , Da Silva Jaqueline , Santana Rosimere Ferreira 
Published: June 2018

Objetivo: identificar evidências sobre adesão terapêutica em idosos hipertensos. Método: Trata-se de revisão integrativa. A coleta
de dado ocorreu na segunda quinzena do mês de agosto de 2015 nas bases de dados da LILACS, MEDLINE via PUBMED e SCIELO.
Utilizou-se os descritores: “Idoso”, “Hipertensão”, “Cuidados de Enfermagem”, “Adesão à medicação”, e o operador booleano and
para os cruzamentos. Para análise, apresentam-se 20 publicações. Resultados: Aspirando melhorar os comportamentos de
autocuidado, o aconselhamento pelo enfermeiro ao paciente idoso é uma estratégia para melhorar a adesão terapêutica.
Conclusão: Identificou-se que as evidências sobre adesão terapêutica em idosos hipertensos, estão relacionadas, ao
desenvolvimento das doenças crônicas não transmissíveis e ao estilo de vida da pessoa idosa. Estratégias que envolvam atitudes e
comportamentos dos idosos podem favorecer um comportamento participativo que contribua para uma adequada adesão
terapêutica.
How to adapt winemaking practices to modified grape composition under climate change conditions
Authors: Dequin Sylvie , Escudier Jean-Louis , Bely Marina , Noble Jessica , Albertin Warren , Masneuf-Pomarède Isabelle , Marullo Philippe , Salmon Jean-Michel , Sablayrolles Jean Marie 
Published: June 2018

Aim: In the context of climate change, adaptation of enological practices and implementation of novel techniques are major challenges for winemakers. The potential interventions are linked in particular with the alcohol content and the global acidity of wine. Here, we review current microbiological and technological strategies to overcome such issues.Methods and results: Reducing ethanol concentration poses a number of technical and scientific challenges, in particular looking for specific yeast strains with lower alcohol yield. Several non-genetically modified organism (GMO) strains – S. cerevisiae or interspecific hybrids of the Saccharomyces genus – have yet been developed using different strategies, and some of them allow decreasing the final ethanol concentration by up to 1%. Several membrane-based technologies have also been developed not only to reduce the ethanol content of wines but also to increase the acidity and more generally to control the wine pH. New strategies are also proposed to improve the control of winemaking, especially the management of alcoholic fermentation of sugar-rich musts and the control of oxidation during the process.Conclusion: Reducing ethanol of wines and increasing their acidity are good examples of novel techniques of interest in the context of climate change. Other strategies are still under study to adapt winemaking practices to changes in grape composition.Significance and impact of the study: [Membrane-based technologies can be used to reduce the ethanol content of wines or to increase the acidity. Microbiological strategies will also be soon available for winemakers.