bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of cardiac function in pediatric patients with mild to moderate bronchial asthma in the era of cardiac strain imaging
Authors: Abdelmohsen Gaser , Mohamed Hossam , Mohsen Mona , Abdelaziz Osama , Ahmed Doaa , Abdelsalam Mohamed , Dohain Ahmed 
Published: August 2019

AbstractObjectiveBronchial asthma is a common chronic inflammatory airway disease, which may be associated with pulmonary hypertension and cardiac dysfunction. The aim of this study was to evaluate the ability of 2D‐speckle tracking echocardiography (2D‐STE) and tissue doppler imaging (TDI) to detect subtle cardiac dysfunction in pediatric patients with mild to moderate bronchial asthma.MethodologyThe study included 30 children with mild to moderate bronchial asthma and 27 age‐matched healthy controls. Both groups underwent pulmonary function tests, TDI and 2D‐STE. Myocardial performance index (MPI), S′, E′, A′ velocities, global strain of left ventricle (LV), right ventricle (RV), and right atrium (RA) were measured.ResultsRV diastolic function was impaired in the patient group, as the tricuspid E′ velocity was significantly lower in the patients when compared with the controls (16 [14‐17] vs 16 [17‐19] cm/s, P = .044), while the RV‐MPI was significantly higher in patients when compared to controls (0.30 [0.27‐0.36] vs 0.30 [0.30‐0.30], P = .001). The global RV longitudinal strain, RA strain, and LV strain did not show significant differences between the test and the control groups. RV systolic parameters and LV systolic and diastolic parameters did not differ significantly between the two groups.ConclusionPediatric patients with mild to moderate bronchial asthma may have early RV diastolic dysfunction with preserved other cardiac functions.
KEGG Mapper for inferring cellular functions from protein sequences
Authors: Kanehisa Minoru , Sato Yoko 
Published: August 2019

AbstractKEGG is a reference knowledge base for biological interpretation of large‐scale molecular datasets, such as genome and metagenome sequences. It accumulates experimental knowledge about high‐level functions of the cell and the organism represented in terms of KEGG molecular networks, including KEGG pathway maps, BRITE hierarchies, and KEGG modules. By the process called KEGG mapping, a set of protein coding genes in the genome, for example, can be converted to KEGG molecular networks enabling interpretation of cellular functions and other high‐level features. Here we report a new version of KEGG Mapper, a suite of KEGG mapping tools available at the KEGG website (https://www.kegg.jp/ or https://www.genome.jp/kegg/), together with the KOALA family tools for automatic assignment of KO (KEGG Orthology) identifiers used in the mapping.
Synthesis, Antitumor and Cytotoxic Activity of New Adamantyl O‐Acylamidoximes and 3‐Aryl‐5‐Adamantane‐1,2,4‐Oxadiazole Derivatives
Authors: Aguiar Deivson Ferreira , Dutra Luana Letícia Alves , Dantas Willyenne Marília , Camelo de Carvalho Guilherme Graziany , Gonçalves Lemes Romélia Pinheiro , do Ó Pessoa Claudia , Koscky Paier Carlos Roberto , Barros Araujo Patricia Lopes , Araujo Elmo Silvano , Pena Lindomar José , de Oliveira Ronaldo Nascimento 
Published: August 2019

AbstractO‐Acylamidoxime and 1,2,4‐oxadiazole derivatives were synthesized from adamantanecarbonyl chloride 1 and a diversity of arylamidoximes 2 a‐k. First, O‐acylamidoximes intermediates 3 a‐k were synthesized and subsequent cyclization under microwave irradiation afforded 1,2,4‐oxadiazol derivatives 4 a‐k. Molar Heat of Reaction Calorimetry studies performed from O‐acylamidoximes revealed influence of the substituent groups. A one‐pot two‐step methodology was also developed proving to be a viable protocol. Compounds were characterized by 1H and 13C Nuclear Magnetic Resonance (NMR) Spectroscopy, Elemental Analysis or High Resolution Mass Spectral Analysis, and subjected to cytotoxic studies in non‐tumoral Vero cells and antiproliferative activity tests in six malignant cell lines. Our findings suggest that compounds 3 derivatives presented a concentration‐dependent profile for chronic myeloid leukemia (K562) and acute promyelocytic leukemia (HL‐60) cell.
Graphene and Graphene/Polymer Composites as the Most Efficient Protective Coatings for Steel, Aluminum and Copper in Corrosive Media: A Review of Recent Studies
Authors: Ehsani Ali , Heidari Ali Akbar , Sajedi Maryam 
Published: August 2019

AbstractThe metal corrosion is considered as a severe threat to the national economy and industry structure, capable of triggering significant economic losses and severe damages, involving innumerable fields in daily life and industries. This review provides an overview of the physioelectrochemical studies on anticorrosive properties of various types of graphene coatings. Required electrochemical techniques for the investigation of anticorrosive efficiency, various types of graphene‐based materials coatings along with different routes to provide desirable coated layers are discussed in detail. After all, we intend to show that the modified graphene nanosheets can be regarded as effective protective layers against metal corrosion not only because of their extraordinary mechanical strength and toughness, which can be reached with a vastly thin layer, but also for their high transparency, cost‐efficiency and stability.
Incisional Hernia After Laparoscopic‐Assisted Right Hemicolectomy
Authors: Sabajo Charissa R. , Olthof Pim B. , Roos Daphne , Dekker Jan Willem T. 
Published: August 2019

AbstractBackgroundDifferent approaches used for laparoscopic right colectomy have different advantages and disadvantages. This study aims to determine the incidence and clinical relevance of IH after LARHC as the preferred technique in an experienced setting and to assess which factors are correlated with the development of IH.MethodsBetween January 2012 and December 2016, all consecutive patients who underwent LARHC were included. Data were obtained in accordance with the Dutch ColoRectal Audit, and IH was scored based on physical examination and imaging at standard follow‐up. Logistic regression analysis was used to identify risk factors for IH.ResultsA total of 170 patients underwent LARHC. In the same period, 64 patients had an open RHC. IH after LARHC was seen in 24 patients after a median time of 7 months (14%). Only four of these patients underwent operative IH repair (2%). Interestingly, a trend for more IH was seen between two surgeons. Multivariable analysis identified BMI [OR 1.08 (95% CI 1.00–1.15) P = 0.043], a history of smoking [OR 2.14 (95% CI 1.03–4.41) P = 0.040], and surgical site infection [OR 2.99 (95% CI 1.28–7.00) P = 0.012] as risk factors for IH.ConclusionIH incidence after LARHC was considerable, but few were clinically relevant IHs. The IH incidence should be included in shared decision making. The low clinically relevant IH rate does in our opinion not outweigh possible advantages of LARHC.
Coronary artery assessment in Kawasaki disease with dual-source CT angiography to uncover vascular pathology
Authors: van Stijn D. , Planken R. N. , Groenink M. , Streekstra G. J. , Kuijpers T. W. , Kuipers I. M. 
Published: August 2019

Abstract
Background
Kawasaki disease (KD) is a vasculitis with formation of coronary artery aneurysms (CAAs) that can lead to myocardial ischemia. Echocardiography is the primary imaging modality for the coronary arteries despite limited visualization. Coronary angiography (CAG) is the gold standard yet invasive with high-radiation exposure. To date however, state-of-the-art CT scanners enable high-quality low-dose coronary computed tomographic angiography (cCTA) imaging. The aim of our study in KD is to report (i) the diagnostic yield of cCTA compared to echocardiography, and (ii) the radiation dose.

Methods and results
We collected data of KD patients who underwent cCTA. cCTA findings were compared with echocardiography results. In 70 KD patients (median age 15.1 years [0.5–59.5 years]; 78% male; 38% giant CAA), the cCTA identified 61 CAAs, of which 34 (56%, with a Z score > 3, in 22 patients) were not detected by echocardiography. In addition, the left circumflex (aneurysmatic in 6 patients) was always visible upon cCTA and not detected upon echocardiography. Calcifications, plaques, and/or thrombi were visualized by cCTA in 25 coronary arteries (15 patients). Calcifications were seen as early as 2.7 years after onset of disease. In 5 patients, the cCTA findings resulted in an immediate change of treatment. The median effective dose (ED) in millisievert differed significantly (p < 0.01) between third-generation dual-source and other CT scanners (1.5 [0.3–9.4] (n = 56) vs 3.8 [1.7–20.0] (n = 14)).

Conclusions
The diagnostic yield of third-generation dual-source cCTA combined with reduced radiation exposure makes cCTA a favorable diagnostic modality to complete the diagnosis and long-term treatment indications for KD.

Key Points
• cCTA is a favorable diagnostic modality to complete the diagnosis and long-term treatment indications for Kawasaki disease.
• Kawasaki disease patients with proven coronary artery involvement on echocardiography require additional imaging.
Melatonin Treatment Ameliorates Hyperhomocysteinemia-Induced Impairment of Erectile Function in a Rat Model
Authors: Tang Zhe , Song Jingyu , Yu Zhe , Cui Kai , Ruan Yajun , Wang Tao , Yang Jun , Wang Shaogang , Liu Jihong 
Published: August 2019

Abstract

Background
Hyperhomocysteinemia (HHcy) has been reported to be strongly correlated with the occurrence of erectile dysfunction (ED), but the mechanisms are not fully understood. Moreover, whether melatonin could be a potential treatment of HHcy-induced ED needs to be elucidated.

Aim
The aim of this study was to investigate the effects of melatonin on HHcy-induced ED and the potential mechanisms via modulating oxidative stress and apoptosis.

Methods
The Sprague-Dawley (SD) rat model of HHcy was induced by 7% methionine (Met)-rich diets. 36 male SD rats were randomly distributed into 3 groups (n = 12 per group): control group, 7% Met group, and 7% Met + melatonin (Mel; 10 mg/kg, intraperitoneal injection) treatment group. After 4 weeks, the erectile function of all rats was evaluated by electrical stimulation of the cavernous nerve. Histologic and molecular alterations of the corpus cavernosum were also analyzed by immunofluorescence, immunohistochemistry, enzyme-linked immunosorbent assay, Western blotting, and polymerase chain reaction.

Outcomes
HHcy-induced ED rat models were successfully established, and Mel could preserve erectile function mainly through inhibiting oxidative stress via the Erk1/2/Nrf2/HO-1 signaling pathway and suppression of apoptosis.

Results
Erectile function was significantly reduced in the rats with HHcy compared with that in the control group and was ameliorated in the HHcy rats treated with Mel. Compared with the control group, the rats in the HHcy group showed the following: (1) higher levels of total plasma homocysteine; (2) fewer neuronal nitric oxide synthase-positive cells in the corpus cavernous; (3) higher levels of reactive oxygen species and malondialdehyde, higher expression levels of nicotinamide adenine dinucleotide phosphate oxidase, and lower activities of superoxide dismutase, indicating an overactivated oxidative stress; (4) lower expression levels of Erk1/2/Nrf2/HO-1 signaling pathway components; and (5) higher levels of apoptosis, as determined by the expression levels of Bax, Bcl-2, and caspase 3. Mel treatment improved the erectile response, as well as histologic and molecular alterations.

Clinical Translation
Our study on a rodent model of HHcy provided evidence that Mel could be a potential therapeutic method for HHcy-related ED.

Conclusions
Mel treatment improves erectile function in rats with HHcy probably by potential antioxidative stress activity. This finding provides evidence for a potential new therapy for HHcy-induced ED.
Corporate Strategy and Subsidiary Performance: The Effect of Product and Geographic Diversification
Authors: Jiao Jie , Liu Yang , Wu Rui , Xia Jun 
Published: August 2019

ABSTRACTIn this study, we argue that foreign subsidiaries may benefit from the corporate strategies of multinational enterprises (MNEs) in different ways in terms of knowledge transfer and strategic flexibility. From this viewpoint, we explore the relationship between product diversification and financial performance of their subsidiaries under the condition of MNE geographic diversification. Using panel data on foreign subsidiaries in European countries from 2006 to 2011, we find a U-shaped relationship between product diversification and subsidiary performance and the joint effect of product and geographic diversification. Given the importance of transition economies in international business today, we conducted a subsample test contrasting the results based on the transitional (Central and Eastern European) versus Western European countries. The contrasting results provide important implications for other transition economies like China. We validate the relationship in several ways in our robustness tests.
International New Ventures from Emerging Economies: Network Connectivity and Legitimacy Building
Authors: Prashantham Shameen , Kumar K , Bhattacharyya Sumelika 
Published: August 2019

ABSTRACTWe develop an integrative perspective on the role of coethnic ties and ties with foreign multinational enterprises (MNEs) – normally studied in isolation of each other – on the perceived legitimacy of international new ventures (INVs) from emerging economies. Building on the notions ofpeople(interpersonal diaspora ties) andpipelines(interorganizational MNE ties) in Lorenzen and Mudambi's connectivity theory of clusters, we argue that these could contribute to the focal INV's internal and external legitimacy, respectively, as it seeks to upgrade its capabilities. We go a step further by highlightingpeople within pipelines– coethnic managers working in foreign MNEs – as a potentially important catalyst of the focal INV's cross-border legitimacy. Using an illustration of an INV from Bangalore, we note that India offers a fruitful setting – and one that is distinct from China – for future INV research into the role of people, pipelines and, in particular, people within pipelines.
A new proof of the Hardy–Rellich inequality in any dimension
Authors: Cazacu Cristian 
Published: August 2019

The Hardy-Rellich inequality in the whole space with the best constant was firstly proved by Tertikas and Zographopoulos in Adv. Math. (2007) in higher dimensions N ⩾ 5. Then it was extended to lower dimensions N ∈ {3, 4} by Beckner in Forum Math. (2008) and Ghoussoub-Moradifam in Math. Ann. (2011) by applying totally different techniques.In this note, we refine the method implemented by Tertikas and Zographopoulos, based on spherical harmonics decomposition, to give an easy and compact proof of the optimal Hardy–Rellich inequality in any dimension N ⩾ 3. In addition, we provide minimizing sequences which were not explicitly mentioned in the quoted papers in lower dimensions N ∈ {3, 4}, emphasizing their symmetry breaking. We also show that the best constant is not attained in the proper functional space.
Sponge community variation along the Apulian coasts (Otranto Strait) over a pluri-decennial time span. Does water warming drive a sponge diversity increasing in the Mediterranean Sea?
Authors: Costa Gabriele , Bavestrello Giorgio , Micaroni Valerio , Pansini Maurizio , Strano Francesca , Bertolino Marco 
Published: August 2019

AbstractClimate change and heavy anthropic pressures are giving rise to important modifications in the rocky benthic communities of the Mediterranean Sea. In particular, sponge assemblages have been deeply affected due to the susceptibility of some species to dramatic phenomena such as mass mortalities or widespread variations in the abundance of other species. For this reason, long-term biodiversity monitoring of the sponge assemblages is important for understanding the direction of changes over time. We studied the sponge fauna living off Tricase Porto (Otranto Strait) and compared its composition with the results of a study conducted in the same area 50 years ago. The comparison indicated that the sponge diversity of this area has strongly increased in the last 50 years and a large number of the sponges recorded in the old survey are still present in the recent community. This evidence matches with other results obtained from different localities of the Mediterranean Sea indicating an increase of sponge diversity, possibly due to the present water warming. The description of two new Demosponge species,Diplastrella boeroisp. nov. andSpirastrella angulatasp. nov., is also provided.
Russian Cosmism: Alien visitations and cosmic energies in contemporary Russia
Authors: TERBISH BAASANJAV 
Published: August 2019

AbstractThis article is about a cultural-philosophical movement called Russian cosmism (Russky kosmizm) and its current status in the Republic of Kalmykia, southwest Russia, home to Buddhist Kalmyks, a people of Oirat-Mongol origin. Emerging in Russia in the early twentieth century and suppressed during the Soviet period, this movement proliferated openly across Russia with the beginning of perestroika. Promulgated as an original product of the Russian mind, cosmism positions itself as a ‘science of the truth and soul searching’ and purports to address various issues, including—but not limited to—the spiritual, psychic, and paranormal anxieties that are on the rise in Russia. Although Russian cosmism is an all-encompassing movement combining various elements of theosophy, philosophy, poetry, theories of evolution and energy, astrology, cosmology, ecology, and even science fiction, this article focuses upon its more cosmic topics—that is, those that are related to outer space, cosmic energies, and alien visitations, as well as responses to these ideas in Kalmykia. The story of Russian cosmism is not just a story of this particular movement, but also that of science in Russia.
Childhood trauma and being at-risk for psychosis are associated with higher peripheral endocannabinoids
Authors: Appiah-Kusi E. , Wilson R. , Colizzi M. , Foglia E. , Klamerus E. , Caldwell A. , Bossong M. G. , McGuire P. , Bhattacharyya S. 
Published: August 2019

AbstractBackgroundEvidence has been accumulating regarding alterations in components of the endocannabinoid system in patients with psychosis. Of all the putative risk factors associated with psychosis, being at clinical high-risk for psychosis (CHR) has the strongest association with the onset of psychosis, and exposure to childhood trauma has been linked to an increased risk of development of psychotic disorder. We aimed to investigate whether being at-risk for psychosis and exposure to childhood trauma were associated with altered endocannabinoid levels.MethodWe compared 33 CHR participants with 58 healthy controls (HC) and collected information about previous exposure to childhood trauma as well as plasma samples to analyse endocannabinoid levels.ResultsIndividuals with both CHR and experience of childhood trauma had higher N-palmitoylethanolamine (p < 0.001) and anandamide (p < 0.001) levels in peripheral blood compared to HC and those with no childhood trauma. There was also a significant correlation between N-palmitoylethanolamine levels and symptoms as well as childhood trauma.ConclusionsOur results suggest an association between CHR and/or childhood maltreatment and elevated endocannabinoid levels in peripheral blood, with a greater alteration in those with both CHR status and history of childhood maltreatment compared to those with either of those risks alone. Furthermore, endocannabinoid levels increased linearly with the number of risk factors and elevated endocannabinoid levels correlated with the severity of CHR symptoms and extent of childhood maltreatment. Further studies in larger cohorts, employing longitudinal designs are needed to confirm these findings and delineate the precise role of endocannabinoid alterations in the pathophysiology of psychosis.
Anhedonia in chronic pain and prescription opioid misuse
Authors: Garland Eric L. , Trøstheim Martin , Eikemo Marie , Ernst Gernot , Leknes Siri 
Published: August 2019

AbstractBackgroundBoth acute and chronic pain can disrupt reward processing. Moreover, prolonged prescription opioid use and depressed mood are common in chronic pain samples. Despite the prevalence of these risk factors for anhedonia, little is known about anhedonia in chronic pain populations.MethodsWe conducted a large-scale, systematic study of anhedonia in chronic pain, focusing on its relationship with opioid use/misuse, pain severity, and depression. Chronic pain patients across four distinct samples (N= 488) completed the Snaith–Hamilton Pleasure Scale (SHAPS), measures of opioid use, pain severity and depression, as well as the Current Opioid Misuse Measure (COMM). We used a meta-analytic approach to determine reference levels of anhedonia in healthy samples spanning a variety of countries and diverse age groups, extracting SHAPS scores from 58 published studies totaling 2664 psychiatrically healthy participants.ResultsCompared to healthy samples, chronic pain patients showed higher levels of anhedonia, with ~25% of patients scoring above the standard anhedonia cut-off. This difference was not primarily driven by depression levels, which explained less than 25% of variance in anhedonia scores. Neither opioid use duration, dose, nor pain severity alone was significantly associated with anhedonia. Yet, there was a clear effect of opioid misuse, with opioid misusers (COMM ⩾13) reporting greater anhedonia than non-misusers. Opioid misuse remained a significant predictor of anhedonia even after controlling for pain severity, depression and opioid dose.ConclusionsStudy results suggest that both chronic pain and opioid misuse contribute to anhedonia, which may, in turn, drive further pain and misuse.
Social context and the real-world consequences of social anxiety
Authors: Hur Juyoen , DeYoung Kathryn A. , Islam Samiha , Anderson Allegra S. , Barstead Matthew G. , Shackman Alexander J. 
Published: August 2019

AbstractBackgroundSocial anxiety lies on a continuum, and young adults with elevated symptoms are at risk for developing a range of psychiatric disorders. Yet relatively little is known about the factors that govern the hour-by-hour experience and expression of social anxiety in the real world.MethodsHere we used smartphone-based ecological momentary assessment (EMA) to intensively sample emotional experience across different social contexts in the daily lives of 228 young adults selectively recruited to represent a broad spectrum of social anxiety symptoms.ResultsLeveraging data from over 11 000 real-world assessments, our results highlight the central role of close friends, family members, and romantic partners. The presence of such close companions was associated with enhanced mood, yet socially anxious individuals had fewer confidants and spent less time with the close companions that they do have. Although higher levels of social anxiety were associated with a general worsening of mood, socially anxious individuals appear to derive larger benefits – lower levels of negative affect, anxiety, and depression – from their close companions. In contrast, variation in social anxiety was unrelated to the amount of time spent with strangers, co-workers, and acquaintances; and we uncovered no evidence of emotional hypersensitivity to these less-familiar individuals.ConclusionsThese findings provide a framework for understanding the deleterious consequences of social anxiety in emerging adulthood and set the stage for developing improved intervention strategies.