bluuebunny/crossref_metadata_2025_split huggingface dataset:
APASL HCV guidelines of virus-eradicated patients by DAA on how to monitor HCC occurrence and HBV reactivation
Authors: Kanda Tatsuo , Lau George K. K. , Wei Lai , Moriyama Mitsuhiko , Yu Ming-Lung , Chuang Wang-Long , Ibrahim Alaaeldin , Lesmana Cosmas Rinaldi Adithya , Sollano Jose , Kumar Manoj , Jindal Ankur , Sharma Barjesh Chander , Hamid Saeed S. , Kadir Dokmeci A. , Mamun-Al-Mahtab  , McCaughan Geoffrey W. , Wasim Jafri , Crawford Darrell H. G. , Kao Jia-Horng , Ooka Yoshihiko , Yokosuka Osamu , Sarin Shiv Kumar , Omata Masao 
Published: September 2019

Abstract
In the direct-acting antiviral (DAA) era for hepatitis C virus (HCV) infection, sustained virological response (SVR) is very high, but close attention must be paid to the possible occurrence of hepatocellular carcinoma (HCC) and reactivation of hepatitis B virus (HBV) in patients with co-infection who achieved SVR in short term. HCC occurrence was more often observed in patients with previous HCC history. We found occurrence of HCC in 178 (29.6%) of 602 patients with previous HCC history (15.4 months mean follow-up post-DAA initiation) but, in contrast, in only 604 (1.3%) of 45,870 patients without previous HCC history (18.2 months mean follow-up). Thus, in these guidelines, we recommend the following: in patients with previous HCC history, surveillance at 4-month intervals for HCC by ultrasonography (US) and tumor markers should be performed. In patients without previous HCC history, surveillance at 6- to 12-month intervals for HCC including US is recommended until the long-term DAA treatment effects, especially for the resolution of liver fibrosis, are confirmed. This guideline also includes recommendations on how to follow-up patients who have been infected with both HCV and HBV. When HCV was eradicated in these HBsAg-positive patients or patients with previous HBV infection (anti-HBc and/or anti-HBs-positive), it was shown that HBV reactivation or HBV DNA reappearance was observed in 67 (41.4%) of 162 or 12 (0.9%) of 1317, respectively. For these co-infected patients, careful attention should be paid to HBV reactivation for 24 weeks post-treatment.
Petrochemical Steel Pipe Rack: Critical Assessment of Existing Design Code Provisions and a Case Study
Authors: Di Sarno Luigi , Karagiannakis George 
Published: September 2019

AbstractThe investigation of the seismic integrity of petrochemical plant steel structures should be commensurable to their importance given the high necessity for human life safety and financial robustness. To date, it is demonstrated in the existing literature that still many grey areas of knowledge exist upon the appropriate application of code provisions on non-building structures design. Indeed, the selection of seismic design parameters such as system performance factors or important classes are still vague aspects, in contrast with those for common building structures, either because of the paucity of information of seismic codes or due to the structural peculiarities that characterise the industrial structures resulting in the difficulty of defining ‘all-encompassing’ design parameters. The present paper aims at highlighting those parameters considering also a case-study that pertains to a steel pipe rack. The pipe rack is designed and analysed in the linear and nonlinear regime, both statically and dynamically, according to the Italian and European codes. American code provisions are examined as well so as possible inconsistencies might be found. It is demonstrated that the common nonlinear static analysis (pushover analysis) cannot be used to assess the response of the rack and the behaviour factor selection from current standards could be unjustifiable. Also, common engineering demand parameters, e.g. interstorey drift ratio, need further assessment vis-à-vis the response of nonstructural components of which the current design method does not comply with modern methods.
Bisexuality, Union Status, and Gender Composition of the Couple: Reexamining Marital Advantage in Health
Authors: Hsieh Ning , Liu Hui 
Published: September 2019

Abstract
It has long been documented that married individuals have better health outcomes than unmarried individuals. However, this marital advantage paradigm has been developed primarily based on heterosexual populations. No studies to date have examined the health effects of marriage among bisexuals, one of the most disadvantaged but understudied sexual minority groups, although a few have shown mixed results for gays and lesbians. Similarly, no research has examined how the gender composition of a couple may shape bisexuals’ health outcomes above and beyond the effects of sexual orientation. We analyzed pooled data from the 2013–2017 National Health Interview Survey (n = 154,485) and found that the health advantage of marriage applied only to heterosexuals and, to a lesser extent, gays and lesbians. Married bisexuals, however, exhibited poorer health than unmarried bisexuals when socioeconomic status and health behaviors were adjusted for. Moreover, bisexuals in same-gender unions were healthier than bisexuals in different-gender unions primarily because of their socioeconomic advantages and healthier behaviors. Together, our findings suggest that bisexuals, particularly those in different-gender unions, face unique challenges in their relationships that may reduce the health advantage associated with marriage.
Accuracy of psychometric tools in the assessment of personality in
adolescents and adults requesting gender-affirming treatments: A systematic
review
Authors: Lehmann Katrin , Leavey Gerard 
Published: September 2019

Abstract

Background:
The assessment and screening for personality disorders in
individuals requesting gender affirming treatments may be an important
aspect of predicting medical and surgical outcomes for this population,
but there is no consensus on how best to do so.

Aims:
To review the diagnostic accuracy of psychometric tools used for the
assessment of personality disorders in those requesting gender affirming
treatments.

Method:
A systematic review: Prospero CRD42017078783 [1].

Results:
Many studies have focussed on the assessment of personality
disorders in this population, but since 1979, only two have used an
index and reference test.

Conclusion:
There are no agreed reference standards for this population and
psychometric tools continue to be scored on reference data from the
cisgender (not transgender) population. We need robust evidence on this
issue, as individuals may be denied access to gender affirming
treatments based on psychometric tools without established reliability
in this population.
New Evidence for a Mid- to Late-Holocene Change in the Marine Reservoir Effect Across the South Pacific Gyre
Authors: Petchey Fiona 
Published: September 2019

AbstractHolocene climate change in the South Pacific is of major interest to archaeologists and Quaternary researchers. Regional surface ocean radiocarbon (14C) values are an established proxy for studying changing oceanographic and climatic conditions. Unfortunately, radiocarbon variability in the marine environment over the period of specific importance to human colonization of the remote Pacific islands—the last 3500 years—has been poorly studied. In order to build robust and accurate archaeological chronologies using shell, it is important to rectify this. In this paper, radiocarbon marine reservoir offsets (ΔR) are presented from eight archaeological sites, ranging in age from 350 cal BP to 3000 cal BP, and compared to coral datasets from the east Australian coastline. The results indicate that a significant decrease in the South Pacific Gyre ΔR occurred between 2600 and 2250 cal BP, most likely caused by changes in ocean circulation and climate. Accurately recording the timing of variability in reservoir offset is critical to untangling changes in society that took place in the Pacific, in particular, the development of Ancestral Polynesian Society.
Design of subwavelength metamaterial resonator based on new self-coupling strategy
Authors: Benkhaoua Larbi , Mouissat Smail , Benhabiles Mohamed Taoufik , Riabi Mohamed Lahdi 
Published: September 2019

AbstractIn this paper, edge-broad-side coupled spiral resonator (EBC-SR) is proposed to enhance the miniaturization of the metamaterial resonators. After a comparative analysis, it is found that the proposed strategy can drastically reduce the electrical size of metamaterial resonators. This is due to the use, at the same time, advantages of edge coupling, broad-side coupling, and self-coupling. A lumped element equivalent circuit model is proposed for the EBC-SR-loaded transmission line. This model is validated by comparing the results of electromagnetic simulations with the circuit simulations using the extracted parameter values. To validate the proposed strategy, a prototype of the EBC-SR embedded inside a drive loop is fabricated. The experimental results are presented with the simulation results.
We Only Believe in News That We Doctored Ourselves
Authors: Faragó Laura , Kende Anna , Krekó Péter 
Published: September 2019

Abstract. In this research we aimed to explore the importance of partisanship behind the belief in wish-fulfilling political fake news. We tested the role of political orientation, partisanship, and conspiracy mentality in the acceptance of pro- and anti-government pipedream fake news. Using a representative survey ( N = 1,000) and a student sample ( N = 382) in Hungary, we found that partisanship predicted belief in political fake news more strongly than conspiracy mentality, and these connections were mediated by the perceived credibility of source (independent journalism vs. political propaganda) and economic sentiment. Our findings suggest that political bias can be more important in predicting acceptance of pipedream political fake news than conspiracy mentality.
A long noncoding RNA binding to QKI-5 regulates germ cell apoptosis via p38 MAPK signaling pathway
Authors: Li Kai , Zhong Shunshun , Luo Yanyun , Zou Dingfeng , Li Mengzhen , Li Yahui , Lu Yan , Miao Shiying , Wang Linfang , Song Wei 
Published: September 2019

AbstractSpermatogenesis is the complex process of male germline development and requires coordinated interactions by multiple gene products that undergo strict developmental regulations. Increasing evidence has suggested that a number of long noncoding RNAs (lncRNAs) may function as important regulatory molecules in various physiological and pathological processes by binding to specific proteins. Here, we identified a subset of QKI-5-binding lncRNAs in the mouse testis through the integrated analyses of RNA immunoprecipitation (RIP)-microarray and biological verification. Among the lncRNAs, we revealed that NONMMUT074098.2 (Lnc10), which was highly expressed in the spermatogonia and spermatocytes of the testis, interacted with QKI-5. Furthermore, Lnc10 depletion promoted germ cell apoptosis via the activation of p38 MAPK, whereas the simultaneous knockdown of QKI-5 could rescue the apoptotic phenotype and the activation of p38 MAPK, which were induced by the loss of Lnc10. These data indicated that the Lnc10-QKI-5 interaction was associated with the regulatory roles of QKI-5 and that the Lnc10-QKI-5 interaction inhibited the regulation of QKI-5 on the downstream p38 MAPK signaling pathway. Additionally, we functionally characterized the biological roles of Lnc10 and found that the knockdown of Lnc10 promoted the apoptosis of spermatogenic cells in vivo; this suggested that Lnc10 had an important biological role in mouse spermatogenesis. Thus, our study provides a potential strategy to investigate the biological significance of lncRNA-RBP interactions during male germline development.
Uprooting defects to enable high-performance III–V optoelectronic devices on silicon
Authors: Bioud Youcef A. , Boucherif Abderraouf , Myronov Maksym , Soltani Ali , Patriarche Gilles , Braidy Nadi , Jellite Mourad , Drouin Dominique , Arès Richard 
Published: September 2019

AbstractThe monolithic integration of III-V compound semiconductor devices with silicon presents physical and technological challenges, linked to the creation of defects during the deposition process. Herein, a new defect elimination strategy in highly mismatched heteroepitaxy is demonstrated to achieve a ultra-low dislocation density, epi-ready Ge/Si virtual substrate on a wafer scale, using a highly scalable process. Dislocations are eliminated from the epilayer through dislocation-selective electrochemical deep etching followed by thermal annealing, which creates nanovoids that attract dislocations, facilitating their subsequent annihilation. The averaged dislocation density is reduced by over three orders of magnitude, from ~108 cm−2 to a lower-limit of ~104 cm−2 for 1.5 µm thick Ge layer. The optical properties indicate a strong enhancement of luminescence efficiency in GaAs grown on this virtual substrate. Collectively, this work demonstrates the promise for transfer of this technology to industrial-scale production of integrated photonic and optoelectronic devices on Si platforms in a cost-effective way.
A Mendelian randomization study of IL6 signaling in cardiovascular diseases, immune-related disorders and longevity
Authors: Rosa Mickael , Chignon Arnaud , Li Zhonglin , Boulanger Marie-Chloé , Arsenault Benoit J. , Bossé Yohan , Thériault Sébastien , Mathieu Patrick 
Published: September 2019

AbstractGrowing evidence suggests that inflammation is a significant contributor to different cardiovascular diseases (CVDs). Mendelian randomization (MR) was performed to assess the causal inference between plasma soluble IL6 receptor (sIL6R), a negative regulator of IL6 signaling, and different cardiovascular and immune-related disorders.Cis-MR with multiple instrumental variables showed an inverse association of sIL6R with rheumatoid arthritis, atrial fibrillation, stroke, coronary artery disease, and abdominal aortic aneurysm. However, genetically-determined sIL6R level was positively associated with atopic dermatitis and asthma. Also, sIL6R level was associated with longevity, as evaluated by parental age at death, a heritable trait. Gene-based association analysis with S-PrediXcan by using tissues from GTExV7 showed thatIL6Rtissue expression-disease pair associations were consistent with the directional effect of IL6 signaling identified in MR. Genetically-determined reduced IL6 signaling lowers the risk of multiple CVDs and is associated with increased longevity, but at the expense of higher atopic risk.
Digital quantum simulation, Trotter errors, and quantum chaos of the kicked top
Authors: Sieberer Lukas M. , Olsacher Tobias , Elben Andreas , Heyl Markus , Hauke Philipp , Haake Fritz , Zoller Peter 
Published: September 2019

AbstractThis work aims at giving Trotter errors in digital quantum simulation (DQS) of collective spin systems an interpretation in terms of quantum chaos of the kicked top. In particular, for DQS of such systems, regular dynamics of the kicked top ensures convergence of the Trotterized time evolution, while chaos in the top, which sets in above a sharp threshold value of the Trotter step size, corresponds to the proliferation of Trotter errors. We show the possibility to analyze this phenomenology in a wide variety of experimental realizations of the kicked top, ranging from single atomic spins to trapped-ion quantum simulators which implement DQS of all-to-all interacting spin-1/2 systems. These platforms thus enable in-depth studies of Trotter errors and their relation to signatures of quantum chaos, including the growth of out-of-time-ordered correlators.
Evaluating FAIR maturity through a scalable, automated, community-governed framework
Authors: Wilkinson Mark D. , Dumontier Michel , Sansone Susanna-Assunta , Bonino da Silva Santos Luiz Olavo , Prieto Mario , Batista Dominique , McQuilton Peter , Kuhn Tobias , Rocca-Serra Philippe , Crosas Mercѐ , Schultes Erik 
Published: September 2019

AbstractTransparent evaluations of FAIRness are increasingly required by a wide range of stakeholders, from scientists to publishers, funding agencies and policy makers. We propose a scalable, automatable framework to evaluate digital resources that encompasses measurable indicators, open source tools, and participation guidelines, which come together to accommodate domain relevant community-defined FAIR assessments. The components of the framework are: (1) Maturity Indicators – community-authored specifications that delimit a specific automatically-measurable FAIR behavior; (2) Compliance Tests – small Web apps that test digital resources against individual Maturity Indicators; and (3) the Evaluator, a Web application that registers, assembles, and applies community-relevant sets of Compliance Tests against a digital resource, and provides a detailed report about what a machine “sees” when it visits that resource. We discuss the technical and social considerations of FAIR assessments, and how this translates to our community-driven infrastructure. We then illustrate how the output of the Evaluator tool can serve as a roadmap to assist data stewards to incrementally and realistically improve the FAIRness of their resources.
All-silicon reconfigurable metasurfaces for multifunction and tunable performance at optical frequencies based on glide symmetry
Authors: Shanei Mohammad Mahdi , Fathi Davood , Ghasemifard Fatemeh , Quevedo-Teruel Oscar 
Published: September 2019

AbstractDielectric metasurfaces have opened promising possibilities to enable a versatile platform in the miniaturization of optical elements at visible and infrared frequencies. Due to high efficiency and compatibility with CMOS fabrication technology, silicon-based metasurfaces have a remarkable potential for a wide variety of optical devices. Adding tunability mechanisms to metasurfaces could be beneficial for their application in areas such as communications, imaging and sensing. In this paper, we propose an all-silicon reconfigurable metasurface based on the concept of glide symmetry. The reconfigurability is achieved by a phase modulation of the transmitted wave activated by a lateral displacement of the layers. The misalignment between the layers creates a new inner periodicity which leads to the formation of a metamolecule with a new sort of near-field interaction. The proposed approach is highly versatile for developing multifunctional and tunable metadevices at optical frequencies. As a proof of concept, in this paper, we design a bifunctional metadevice, as well as a tunable lens and a controllable beam deflector operating at 1.55 μm.
Pioglitazone treatment prior to transplantation improves the efficacy of human mesenchymal stem cells after traumatic brain injury in rats
Authors: Das Mahasweta , Mayilsamy Karthick , Tang Xiaolan , Han Jung Yeon , Foran Elspeth , Willing Alison E. , Mohapatra Shyam S. , Mohapatra Subhra 
Published: September 2019

AbstractTraumatic brain injury is a leading cause of death and disability around the world. So far, drugs are not available to repair brain damage. Human mesenchymal stem cell (hMSC) transplantation therapy is a promising approach, although the inflammatory microenvironment of the injured brain affects the efficacy of transplanted hMSCs. We hypothesize that reducing the inflammation in the cerebral microenvironment by reducing pro-inflammatory chemokines prior to hMSC administration will improve the efficacy of hMSC therapy. In a rat model of lateral fluid percussion injury, combined pioglitazone (PG) and hMSC (combination) treatment showed less anxiety-like behavior and improved sensorimotor responses to a noxious cold stimulus. Significant reduction in brain lesion volume, neurodegeneration, microgliosis and astrogliosis were observed after combination treatment. TBI induced expression of inflammatory chemokine CCL20 and IL1-β were significantly decreased in the combination treatment group. Combination treatment significantly increased brain-derived neurotrophic factor (BDNF) level and subventricular zone (SVZ) neurogenesis. Taken together, reducing proinflammatory cytokine expression in the cerebral tissues after TBI by PG administration and prior to hMSC therapy improves the outcome of the therapy in which BDNF could have a role.
Inflammation markers in the saliva of infants born from Zika-infected mothers: exploring potential mechanisms of microcephaly during fetal development
Authors: de Oliveira Diogo N. , Lima Estela O. , Melo Carlos F. O. R. , Delafiori Jeany , Guerreiro Tatiane M. , Rodrigues Rafael G. M. , Morishita Karen N. , Silveira Cynthia , Muraro Stéfanie Primon , de Souza Gabriela Fabiano , Vieira Aline , Silva Antônio , Batista Rosângela F. , Doriqui Maria J. R. , Sousa Patricia S. , Milanez Guilherme P. , Proença-Módena José L. , Cavalcanti Denise P. , Catharino Rodrigo R. 
Published: September 2019

AbstractZika virus (ZIKV) has emerged as one of the most medically relevant viral infections of the past decades; the devastating effects of this virus over the developing brain are a major matter of concern during pregnancy. Although the connection with congenital malformations are well documented, the mechanisms by which ZIKV reach the central nervous system (CNS) and the causes of impaired cortical growth in affected fetuses need to be better addressed. We performed a non-invasive, metabolomics-based screening of saliva from infants with congenital Zika syndrome (CZS), born from mothers that were infected with ZIKV during pregnancy. We were able to identify three biomarkers that suggest that this population suffered from an important inflammatory process; with the detection of mediators associated with glial activation, we propose that microcephaly is a product of immune response to the virus, as well as excitotoxicity mechanisms, which remain ongoing even after birth.
Identification and validation of potential reference gene for effective dsRNA knockdown analysis in Chilo partellus
Authors: Adeyinka Olawale Samuel , Tabassum Bushra , Nasir Idrees Ahmad , Yousaf Iqra , Sajid Imtiaz Ahmad , Shehzad Khurram , Batcho Anicet , Husnain Tayyab 
Published: September 2019

AbstractChilo partellus is an invasive polyphagous pest that has not been effectively managed with chemical pesticides. To select potential dsRNAs for use in an alternate control strategy, it is crucial to identify and evaluate stable reference genes for knockdown expression studies. This study evaluates the expression stability of seven candidate reference genes in C. partellus larvae fed on crude bacterially-expressed dsRNAs and purified dsRNAs at different time intervals, as well as the developmental stages and sexes. The expression stabilities of the reference genes were evaluated with different software programmes, such as BestKeeper, NormFinder, deltaCt, geNorm, and RefFinder. The overall results rank ELF as the most stably expressed reference gene when larvae were fed with crude bacteria-induced dsRNAs and purified dsRNA. However, Tubulin and HSP70 were more stable under different developmental stages and sexes. The expression levels of larvae that were fed crude bacteria-induced dsRNAs of Chitinase and Acetylcholinesterase were normalized with the four most stable reference genes (ELF, HSP70, V-ATPase and Tubulin) and the least stable reference gene (18S and HSP70) based on the geNorm algorithm. The least stable reference gene showed inconsistent knockdown expression, thereby confirming that the validation of a suitable reference gene is crucial to improve assay accuracy for dsRNA-targeted gene selection in C. partellus.