bluuebunny/crossref_metadata_2025_split huggingface dataset:
Data‐Driven Supply Chain Orientation and Financial Performance: The Moderating Effect of Innovation‐Focused Complementary Assets
Authors: Yu Wantao , Jacobs Mark A. , Chavez Roberto , Feng Mengying 
Published: May 2019

AbstractDrawing on the complementary assets framework, this study explores the moderating effect of innovation‐focused complementary assets (CA‐I) on the relationship between a data‐driven supply chain orientation (DDSCO) and firm financial performance. To test the moderating effect, survey data gathered from 329 manufacturing firms in China were analysed using a moderated regression analysis. The results indicate that DDSCO has a significant positive effect on financial performance, and that capabilities for product and process innovation function as complementary assets moderating the DDSCO–performance relationship. The findings suggest that innovation‐focused complementary assets are performance differentiators when paired with a DDSCO and explain why some firms obtain financial benefits from the development of a DDSCO while others do not. Specifically, competitive advantage from a DDSCO may not be realized unless CA‐I and potentially other complementary assets are harnessed, thus providing useful practical guidance to managers. Hence, the study provides empirical support for the complementary assets framework.
Big Data Analytics Capabilities and Innovation: The Mediating Role of Dynamic Capabilities and Moderating Effect of the Environment
Authors: Mikalef Patrick , Boura Maria , Lekakos George , Krogstie John 
Published: May 2019

AbstractWith big data analytics growing rapidly in popularity, academics and practitioners have been considering the means through which they can incorporate the shifts these technologies bring into their competitive strategies. Drawing on the resource‐based view, the dynamic capabilities view, and on recent literature on big data analytics, this study examines the indirect relationship between a big data analytics capability (BDAC) and two types of innovation capabilities: incremental and radical. The study extends existing research by proposing that BDACs enable firms to generate insight that can help strengthen their dynamic capabilities, which in turn positively impact incremental and radical innovation capabilities. To test their proposed research model, the authors used survey data from 175 chief information officers and IT managers working in Greek firms. By means of partial least squares structural equation modelling, the results confirm the authors’ assumptions regarding the indirect effect that BDACs have on innovation capabilities. Specifically, they find that dynamic capabilities fully mediate the effect on both incremental and radical innovation capabilities. In addition, under conditions of high environmental heterogeneity, the impact of BDACs on dynamic capabilities and, in sequence, incremental innovation capability is enhanced, while under conditions of high environmental dynamism the effect of dynamic capabilities on incremental innovation capabilities is amplified.
Brain responses to anticipating and receiving beer: Comparing light, at‐risk, and dependent alcohol users
Authors: Groefsema Martine M. , Engels Rutger C.M.E. , Voon Valerie , Schellekens Arnt F.A. , Luijten Maartje , Sescousse Guillaume 
Published: May 2019

AbstractImpaired brain processing of alcohol‐related rewards has been suggested to play a central role in alcohol use disorder. Yet, evidence remains inconsistent and mainly originates from studies in which participants passively observe alcohol cues or taste alcohol. Here, we designed a protocol in which beer consumption was predicted by incentive cues and contingent on instrumental action closer to real life situations. We predicted that anticipating and receiving beer (compared with water) would elicit activity in the brain reward network and that this activity would correlate with drinking level across participants.The sample consisted of 150 beer‐drinking males, aged 18 to 25 years. Three groups were defined based on alcohol use disorders identification test (AUDIT) scores: light drinkers (n = 39), at‐risk drinkers (n = 64), and dependent drinkers (n = 47). fMRI measures were obtained while participants engaged in the beer incentive delay task involving beer‐ and water‐predicting cues followed by real sips of beer or water.During anticipation, outcome notification and delivery of beer compared with water, higher activity was found in a reward‐related brain network including the dorsal medial prefrontal cortex, orbitofrontal cortex, and amygdala. Yet, no activity was observed in the striatum, and no differences were found between the groups.Our results reveal that anticipating, obtaining, and tasting beer activates parts of the brain reward network, but that these brain responses do not differentiate between different drinking levels.
Impact of next‐generation sequencing panels in the evaluation of limb‐girdle muscular dystrophies
Authors: Özyilmaz Berk , Kirbiyik Özgür , Özdemir Taha R. , Kaya Özer Özge , Kutbay Yaşar B. , Erdogan Kadri M. , Güvenç Merve Saka , Kale Murat Yildirim , Gazeteci Hande , Kiliç Betül , Sertpoyraz Filiz , Diniz Gulden , Baydan Figen , Gençpinar Pinar , Dündar Nihal Olgaç , Yiş Uluç 
Published: May 2019

AbstractIntroductionLimb‐girdle muscular dystrophy (LGMD) is the fourth most common muscular dystrophy, with progressive proximal muscle weakness. However, a large number of neuromuscular conditions are similarly presented. Because of this, the use of high‐throughput methods such as next‐generation sequencing (NGS) is important in the evaluation of LGMD.MethodsIn this report, we applied a custom target capture‐based NGS panel covering 31 LGMD‐associated genes (MYOT, LMNA, CAV3, DES, DNAJB6, FLNC, CAPN3, DYSF, SGCG, SGCA, SGCB, SGCD, TCAP, TRIM32, FRKP, TTN, POMT1, ANO5, FKTN, POMT2, POMGnT1, DAG1, PLEC, GAA, GMPPB, HNRNPDL, TNPO3, LIMS2, POMK, TRAPPC11, ISPD) in 74 patients suspected of LGMD.ResultsIn 25 (33.8%) out of 74 patients analyzed, one or more pathogenic/likely pathogenic variants in 13 different genes were detected. Six of the patients had the variants that were not found in databases and literature; thus, they were interpreted as novel pathogenic variants.DiscussionThe diagnosis rate achieved (33.8%) is consistent with previous literature reports and underlines the efficiency and importance of NGS technology in the molecular genetic evaluation of LGMD.
Shear adhesive performance of leaf‐cutting ant workers (Atta cephalotes)
Authors: Stark Alyssa Y. , Davis Hayden R. , Harrison William K. 
Published: May 2019

AbstractWingless arboreal ants must resist the force of gravity while traversing substrates in their environment. For leaf‐cutting ants like Atta cephalotes, foraging may also include a ca. 30 m vertical descent while carrying a load 1–6 times their body mass. We hypothesized that heavier and larger ants would carry heavier and larger loads and that adhesive performance would positively correlate with load mass. We found no relationship between ant mass, body length, head width, or adhesive performance, and the load size an ant carried. In addition to workers carrying vegetative loads (most often leaves), workers in an active foraging trail also include smaller workers riding on the leaves carried by larger workers, and large major workers, providing protection from aerial and ground attacks (Soldiers), respectively. Despite varying functional roles, all foraging ants require secure attachment to the substrate. We measured shear adhesive performance of each foraging role and found that Soldiers produced the highest shear adhesive forces. However, when controlling for tarsal pad area, we found that ants carrying loads have higher shear adhesive performance per unit area than those riding on leaves, and that Soldiers have the lowest shear adhesive performance per unit area. This suggests that while leaf choice does not appear to be dictated by size, mass, or shear adhesive performance of individual ants, overall, ants who carry leaves adhere more strongly given their pad size than those who do not.Abstract in Spanish is available with online material.
Lipids and insulin regulate mitochondrial‐derived peptide (MOTS‐c) in PCOS and healthy subjects
Authors: Ramanjaneya Manjunath , Jerobin Jayakumar , Bettahi Ilham , Bensila Milin , Aye Myint , Siveen Kodappully Sivaraman , Sathyapalan Thozhukat , Skarulis Monica , Abou‐Samra Abdul‐Badi , Atkin Stephen L. 
Published: May 2019

AbstractObjectivePolycystic ovarian syndrome (PCOS) is a heterogeneous endocrine disorder associated with mitochondrial dysfunction and insulin resistance (IR). MOTS‐c, a mitochondrial peptide, promotes insulin sensitivity (IS) through activating AKT and AMPK‐dependent pathways. The current study was designed to examine the response of MOTS‐c to lipids (intralipid) followed by insulin in PCOS and healthy subjects.MethodsAll subjects underwent 5‐hour intralipid/saline infusion with a hyperinsulinemic‐euglycaemic clamp in the final 2 hours. Plasma samples were collected to measure circulating MOTS‐c using a commercial ELISA kit. Subsequently, this was repeated following an eight‐week exercise intervention.ResultsIntralipid significantly increased plasma MOTS‐c both in controls and PCOS subjects, whilst the insulin infusion blunted the intralipid‐induced response seen for both lipids and MOT‐c.Intralipid elevated plasma MOTS‐c to 232 ± 124% of basal in control (P < 0.01) and to 349 ± 206% of basal in PCOS (P < 0.001) subjects. Administration of insulin suppressed intralipid‐induced MOTS‐c from 232 ± 124% to 165 ± 97% (NS) in control and from 349 ± 206% to 183 ± 177% (P < 0.05) in PCOS subjects, respectively. Following exercise, intralipid elevated plasma MOTS‐c to 305 ± 153% of basal in control (P < 0.01) and to 215 ± 103% of basal in PCOS (P < 0.01) subjects; insulin suppressed intralipid‐induced MOTS‐c only in controls.ConclusionsIn conclusion, this is the first study to show increased lipid enhanced circulating MOTS‐c whilst insulin attenuated the MOTS‐c response in human. Further, eight weeks of moderate exercise training did not show any changes in circulating MOTS‐c levels in healthy controls and in women with PCOS.
Retrospective clinical evaluation of implant‐supported single crowns: Mean follow‐up of 15 years
Authors: Chrcanovic Bruno Ramos , Kisch Jenö , Larsson Christel 
Published: May 2019

AbstractObjectiveTo retrospectively assess the clinical outcomes of implant‐supported single crowns and the supporting implants.Material and MethodsThis retrospective study included all patients treated with implant‐supported single crowns at one specialist clinic. Implant and prosthesis failure, and mechanical/technical complications (ceramic fracture/chipping; crown loss of retention/mobility; crown failure/fracture; loosening/loss/fracture of prosthetic screw; and implant failure/fracture) were the outcomes analyzed. Any condition/situation that led to the removal/replacement of crowns was considered prosthesis failure.ResultsA total of 438 patients with 567 crowns were included. Mean ± SD follow‐up of 183.4 ± 69.3 months. A total of 37 implants (6.5%) and 54 crowns (9.5%) failed. If only technical problems were considered, the crown failure rate decreased to 4.1% (23/567). Most common reasons for crown failure: esthetic issue (n = 12), crown constantly mobile (n = 9), change to another type of prosthesis together with other implants (n = 8), crown fracture (n = 7), and crown in infraposition in comparison with adjacent teeth (n = 7). The odds of crown failure were shown to be statistically significantly higher for the following factors: younger patients, maxillary crowns, and screw‐retained crowns. Loose prosthetic screw was much more prevalent in screw‐retained than in cemented crowns. Ceramic fracture/chipping was more prevalent in screw‐retained crowns, maxillae, females. Crown fracture was more prevalent in ceramic crowns, screw‐retained crowns, maxillae, posterior region, females. However, these differences were statistically significant only for crown fractures in females.ConclusionsThe odds of crown failure were significant for some factors, but one must keep in mind that non‐technical complications are as common as technical ones as reasons for the replacement of implant‐supported single crowns.
Contact allergy to beeswax and propolis among patients with cheilitis or facial dermatitis
Authors: Nyman Gunnar S. A. , Tang Mimmi , Inerot Annika , Osmancevic Amra , Malmberg Per , Hagvall Lina 
Published: May 2019

AbstractBackgroundBeeswax, both white and yellow, has many uses, such as in lip balm. This material can cause contact allergy, although not many cases have been described.MethodsNinety‐five patients with contact cheilitis, facial eczema or a suspicion of contact allergy to beeswax were patch tested with yellow and white beeswax and with propolis, in addition to the Swedish baseline series. Patients who reacted positively to beeswax were additionally tested with caffeic acid, and two derivatives thereof that are believed to be important haptens in propolis.ResultsSeventeen patients had positive reactions to beeswax. Fourteen of these patients had been tested with both yellow and white beeswax. Among those 14, eight had positive reactions to both types of wax, five only to yellow wax, and one only to white wax. Of the 10 wax‐positive patients tested with caffeic acid derivatives, three reacted positively. Fourteen beeswax‐positive patients also had positive reactions to propolis.ConclusionPatch testing cheilitis patients is important, as contact allergy is common. Our suggestion is to patch test, apart from the baseline series and the patient's own products, also with beeswax and propolis. Many beeswax‐allergic cheilitis patients would not have been diagnosed with a relevant contact allergy if only the Swedish baseline series had been used.
Pathline Density Distributions in a Null‐Space Monte Carlo Approach to Assess Groundwater Pathways
Authors: Moeck Christian , Molson John , Schirmer Mario 
Published: May 2019

AbstractA null‐space Monte‐Carlo (NSMC) approach was applied to account for uncertainty in the calibration of the hydraulic conductivity (K) field for a three‐dimensional groundwater flow model of a major water supply system in Switzerland. The approach generates different parameter realizations of the K field using the pilot point methodology. Subsequently, particle tracking (PT) was applied to each calibrated model, and the resulting particles are interpreted as the spatial pathline density distribution of multiple sources. The adopted approach offers advantages over classical PT which does not provide a means for treating uncertainty originating from the incomplete description of subsurface heterogeneity. Uncertainty in the K field is shown to strongly influence the spatial pathline distribution. Pathline spreading is particularly evident in locations where the information content of the head observations does not sufficiently constrain the estimated parameters. Despite the predictive uncertainty, the pumped drinking water at the study site is most likely dominated by artificially‐infiltrated groundwater originating from the local infiltration canals. The model suggests that within the well field, the central pumping wells could be extracting regional groundwater, although the probability is relatively low. Nevertheless, a rigorous uncertainty assessment is still required since only a few realizations resulted in flow paths that support the field observations. Model results should therefore not be based on only one model realization; rather, an uncertainty analysis should be carried out to provide a sufficiently large suite of equally probable simulations that include all potential sources and pathways.
Usefulness of a salt check sheet for elementary school and junior high school children
Authors: Fujiwara Takeshi , Kikuchi Kaori , Hoshide Satoshi , Tsuchihashi Takuya , Kario Kazuomi 
Published: May 2019

AbstractThere are no known methods to easily evaluate the dietary salt intake of children. We hypothesized that the salt check sheet, for which validity has been confirmed in both hypertensive outpatients and in the general population, can be used to assess dietary salt intake in children. We enrolled 188 healthy schoolchildren (mean age 11.2 ± 1.1 years, 53.2% boys) and asked them to answer both the salt check sheet and a brief self‐administered dietary history questionnaire for Japanese schoolchildren aged 6‐18 years (BDHQ15y). The mean total salt check‐sheet score was 12.7 ± 4.0 points (range: 4‐24 points), and the estimated daily salt intake from the BDHQ15y was 12.1 ± 3.7 g (range: 4.7‐27.2 g). The total check‐sheet score was significantly positively correlated with the estimated daily salt intake from the BDHQ15y (r = 0.408, P < 0.001). Thirty‐one study participants were assigned to the “low” salt group (total score on the salt check sheet was 0‐8 points), 78 participants to the “medium” salt group (9‐13 points), and 79 participants to the “high and very high” salt group (≥14 points), and a comparison estimating daily salt intake from the BDHQ15y among the three groups was performed. Daily salt‐intake levels tended to increase as the group of total check‐sheet scores increased: “low” vs “medium” vs “high and very high” salt group levels were 9.5 ± 3.1 vs 11.6 vs 13.5 ± 3.9, respectively (P < 0.001). This demonstrates that the salt check sheet is a useful tool to easily assess dietary salt intake in children.
Rainbow trout Oncorhynchus mykiss (Walbaum) type IV ice‐structuring protein LS‐12 in the acute‐phase response to Flavobacterium psychrophilum infection
Authors: Di Natale Adrian , Jarau Maureen , Russell Spencer K. , Horricks Ryan A. , Lillie Brandon N. , Dixon Brian , Lumsden John S. 
Published: May 2019

AbstractA previous proteomic study examining the plasma acute‐phase response of rainbow trout to sterile inflammation highlighted an unidentified 9.5‐kDa spot using 2D‐PAGE, which was dramatically increased. The 15 amino acid sequence obtained from this protein spot allowed rapid amplification of cDNA ends PCR to generate a 443‐bp nucleotide sequence that was 98.6% similar to type‐4 ice‐structuring protein LS‐12 from Atlantic salmon Salmo salar Linnaeus. Quantitative reverse translation PCR and an ELISA were used to measure gene expression and plasma concentrations of LS‐12 following experimental intraperitoneal injection of rainbow trout with either 106 or 108 colony‐forming units (CFU) of Flavobacterium psychrophilum. There was no significant change in the plasma concentration of LS‐12 up to 15 days post‐infection in any group. Hepatic LS‐12 gene expression was significantly reduced at 3 and 6 days (p < 0.001) post‐infection in fish injected with 108 CFU of F. psychrophilum relative to control fish, while branchial or head kidney expression was unchanged. Infected fish had significantly increased hepatic gene expression of serum amyloid A, confirming an acute‐phase response. Under the conditions used, LS‐12 is not a positive acute‐phase protein in rainbow trout.
Preparation of low‐density polyethylene film with quercetin and α‐tocopherol loaded with mesoporous silica for synergetic‐release antioxidant active packaging
Authors: Li Cheng , Qiu Xiao‐Lin , Lu Li‐Xin , Tang Ya‐Li , Long Qing , Dang Jin‐Gui 
Published: May 2019

AbstractIn this study, synergetic and controlled‐release low‐density polyethylene (LDPE) antioxidant active films were prepared by cast extrusion. A well‐ordered (4 nm) Mobil Composition of Matter No. 41 (MCM‐41) was prepared to carry α‐tocopherol for reducing the diffusivity (D), while improving the D of quercetin. Characterization of MCM‐41 included small angle X‐ray scattering, scanning electron microscopy, Fourier transform infrared spectroscopy, and nitrogen adsorption/desorption testing. New films added α‐tocopherol and α‐tocopherol loaded with MCM‐41 on the base of a LDPE film containing quercetin. Testing of new films covered the physical properties, release behavior, and 2,2‐diphenyl‐1‐picrylhydrazyl free radical‐scavenging assays. The physical properties discussed differences among any additives, which contain mechanical and barrier properties. Release experiments showed the controlled‐release of MCM‐41 to α‐tocopherol, while addition of α‐tocopherol promoted the release of quercetin in food simulant (95% ethanol). Free radical scavenging increased obviously after adding α‐tocopherol and α‐tocopherol loaded with MCM‐41. This study demonstrated the feasibility of synergetic and controlled‐release antioxidant active packaging films.Practical ApplicationThis work provides a method to control the release of α‐tocopherol in the packaging films using molecular sieve MCM‐41, and promotes the release of quercetin. The preservation of easily oxidized fatty foods is very important. In addition to the usual high‐barrier composite packaging, the release‐type antioxidant packaging is also a method. Food antioxidant packaging film is an important research direction in the field of intelligent packaging, and has great potential in the field of food flexible packaging. Release‐type antioxidants are added to the packaging substrate, and the release rate of antioxidants is adjusted to prevent the oxidation of contents, to extend the shelf life of butter, and other commodities in the process of commodity storage and transportation.
Predictive and concurrent validity of the Malnutrition Universal Screening Tool using mid‐upper arm circumference instead of body mass index
Authors: Gottschall C. , Tarnowski M. , Machado P. , Raupp D. , Marcadenti A. , Rabito E. I. , Silva F. M. 
Published: May 2019

AbstractBackgroundConsidering the difficulty in obtaining weight and height measurements of patients at hospital admission, the Malnutrition Universal Screening Tool (MUST) proposes the use of mid‐upper arm circumference (MUAC) instead of body mass index (BMI) as an alternative for screening of malnutrition risk. The present study aimed to evaluate the performance of MUST with MUAC in place of BMI to identify nutritional risk and predict prolonged hospitalisation and mortality in hospitalised patients.MethodsThe prospective cohort study involved ambulant patients aged ≥18 years who were admitted to the emergency department of a public hospital. A questionnaire concerning clinical and socio‐demographic data was applied and anthropometric measurements were performed (weight, height, BMI and MUAC). Nutritional risk screening was performed using the original MUST (BMI) and MUST‐MUAC tools. The outcomes were length of hospital stay and death.ResultsSeven hundred and fifty‐two patients were included and followed‐up for 13.5 (interquartile range 3.00–19.00) days. The frequency of patients at nutritional risk was higher according to MUST‐MUAC (48.9%) compared to the original MUST (37.1%). MUST‐MUAC showed concurrent validity, demonstrating good agreement with the original MUST (k = 0.690), high sensitivity (95.3%) and accuracy (area under the curve = 0.868; 95% confidence interval = 0.841–0.895) with respect to identifying nutritional risk. The presence of nutritional risk detected by the MUST‐MUAC increased the chance of prolonged hospital stay by 1.9 (95% CI. 1.4–2.7)‐fold and mortality by 3.2 (95% CI. 1.1–9.4)‐fold.ConclusionsMUST‐MUAC showed satisfactory concurrent and predictive validity. Considering that MUAC measurement is easier to perform than BMI, the MUST‐MUAC should be used for screening of nutritional risk in hospitalised patients.