bluuebunny/crossref_metadata_2025_split huggingface dataset:
Addition of granulosa cells collected from differential follicle stages supports development of oocytes derived from porcine early antral follicles
Authors: Ishiguro Ai , Munakata Yasuhisa , Shirasuna Koumei , Kuwayama Takehito , Iwata Hisataka 
Published: October 2018

AbstractPurposeImprovement of in vitro oocyte growth by addition of granulosa cells derived from differential developmental stages of follicles.MethodsGranulosa cells (GCs) collected from either early antral follicles (EAFs) or antral follicles (AFs) were added to oocyte‐granulosa cell complexes (OGCs) derived from EAFs, and the in vitro growth of the oocytes was evaluated.ResultsGranulosa cells were incorporated into OGCs to form new OGCs within 2 days of culture. After 14 days of culture, the number of GCs surrounding oocytes was similar among the three OGCs conditions (unmanipulated “natural OGCs,” “EAF‐GCs add OGCs,” and “AF‐GCs add OGCs”), whereas the survival rate of the GCs and diameter of oocytes grown in vitro were the greatest for “AF‐GCs added OGCs.” After parthenogenetic activation, developmental rate till the blastocyst stage tended to be higher for “AF‐GCs add OGCs” compared with other groups. Addition of AF‐GCs significantly increased a hypoxic marker (pimonidazole staining) and increased the lipid content in oocytes grown in vitro compared with unmanipulated OGCs.ConclusionAddition of GCs derived from more advanced stages of follicles to the OGCs changes the metabolism of oocytes and is beneficial for in vitro growth of oocytes derived from EAFs.
Going beyond serology for stratifying the risk of CMV infection in transplant recipients
Authors: Navarro David , Fernández‐Ruiz Mario , Aguado José María , Sandonís Virginia , Pérez‐Romero Pilar 
Published: October 2018

SummaryKnowledge of donor and recipient (D/R) cytomegalovirus (CMV) serostatus is critical for risk stratification of CMV infection and disease in transplant recipients, particularly in the solid organ transplantation (SOT) setting. Despite its broad availability and the success of it use, the risk stratification based on the D/R serostatus is not free of limitations since there are a nondepreciable number of patients that are not accurately categorized by this approach. In fact, up to 20% of seropositive SOT recipients, classically considered at intermediate risk, develop episodes of CMV infection and disease after transplantation. Here, we provide an overview of additional donor and recipient factors that may have utility in identifying patients at risk for post‐transplant CMV infection. Specifically, we summarize our current understanding regarding the potential use of use CMV‐specific T‐cell‐mediated immunity, neutralizing antibodies and host genetics that may influence the risk of CMV infection and disease. We provide an overview of the benefits and limitations associated with using these immunological factors in risk stratification and propose specific variables that could be analyzed at the pretransplant evaluation to improve the identification of patients with increased individual susceptibility.
Bounded control of feedforward time‐delay systems with linearized systems consisting of chain of oscillators
Authors: Yang Xuefei , Zhou Bin , Lam James 
Published: October 2018

SummaryFor the global stabilization of a family of feedforward nonlinear time‐delay systems whose linearized systems consist of a chain of identical oscillators, a saturated feedback control is established based on a special canonical form. The proposed control laws use not only the current states but also the delayed states for feedback, which helps maintain the decoupling property in the recursive design. Moreover, explicit conditions guaranteeing the stability of the closed‐loop system are provided. When the nonlinear terms vanish and even the oscillators are distinct, a modified saturated feedback control can still be established for the corresponding global stabilization problem. Two numerical examples are given to illustrate the effectiveness of the proposed approaches.
Equivalence of several stability conditions for switched linear systems with dwell time
Authors: Li Yang , Zhang Hongbin , Zhang Liangliang 
Published: October 2018

SummaryIn this paper, several equivalent stability conditions for switched linear systems with dwell time are presented. Both continuous‐time and discrete‐time cases are considered. For the continuous‐time case, the conditions that are convex in system matrices are presented in terms of infinite‐dimensional linear matrix inequalities (LMIs), which are not numerically testable. Then, by adopting the sum of square (SOS) and piecewise linear approach, computable conditions are formulated in terms of SOS program and LMIs. Compared to the literature, less conservative results can be obtained through solving these conditions for the same polynomial degree or discretized order. For the discrete‐time case, the stability conditions, which are convex in system matrices, are numerically testable. The convexity comes at the price of increment of computational complexity. Furthermore, by adopting the convexification approach, sufficient stability conditions of switched linear systems with polytopic uncertainties are derived, both for continuous‐time and discrete‐time cases. At last, several examples are given to demonstrate the correctness and advantages of our results.
A global assessment of atoll island planform changes over the past decades
Authors: Duvat Virginie K. E. 
Published: October 2018

Over the past decades, atoll islands exhibited no widespread sign of physical destabilization in the face of sea‐level rise. A reanalysis of available data, which cover 30 Pacific and Indian Ocean atolls including 709 islands, reveals that no atoll lost land area and that 88.6% of islands were either stable or increased in area, while only 11.4% contracted. Atoll islands affected by rapid sea‐level rise did not show a distinct behavior compared to islands on other atolls. Island behavior correlated with island size, and no island larger than 10 ha decreased in size. This threshold could be used to define the minimum island size required for human occupancy and to assess atoll countries and territories' vulnerability to climate change. Beyond emphasizing the major role of climate drivers in causing substantial changes in the configuration of islands, this reanalysis of available data indicates that these drivers explain subregional variations in atoll behavior and within‐atoll variations in island and shoreline (lagoon vs. ocean) behavior, following atoll‐specific patterns. Increasing human disturbances, especially land reclamation and human structure construction, operated on atoll‐to‐shoreline spatial scales, explaining marked within‐atoll variations in island and shoreline behavior. Collectively, these findings highlight the heterogeneity of atoll situations. Further research needs include addressing geographical gaps (Indian Ocean, Caribbean, north‐western Pacific atolls), using standardized protocols to allow comparative analyses of island and shoreline behavior across ocean regions, investigating the role of ecological drivers, and promoting interdisciplinary approaches. Such efforts would assist in anticipating potential future changes in the contributions and interactions of key drivers.This article is categorized under:

Assessing Impacts of Climate Change > Observed Impacts of Climate Change
Paleoclimates and Current Trends > Earth System Behavior
Perioperative Outcomes of Laparoscopic Repeat Liver Resection for Recurrent HCC: Comparison with Open Repeat Liver Resection for Recurrent HCC and Laparoscopic Resection for Primary HCC
Authors: Goh Brian K. P. , Syn Nicholas , Teo Jin‐Yao , Guo Yu‐Xin , Lee Ser‐Yee , Cheow Peng‐Chung , Chow Pierce K. H. , Ooi London L. P. J. , Chung Alexander Y. F. , Chan Chung‐Yip 
Published: October 2018

AbstractBackgroundThis study aims to determine the safety and efficacy of laparoscopic repeat liver resection (LRLR) for recurrent hepatocellular carcinoma (rHCC).MethodsTwenty patients underwent LRLR for rHCC between 2015 and 2017. The control groups consisted of 79 open RLR (ORLR) for rHCC and 185 LLR for primary HCC. We undertook propensity score‐adjusted analyses (PSA) and 1:1 propensity score matching (PSM) for the comparison of LRLR versus ORLR. Comparison of LRLR versus LLR was done using multivariable regression models with adjustment for clinically relevant covariates.ResultsTwenty patients underwent LRLR with three open conversions (15%). Both PSA and 1:1‐PSM demonstrated that LRLR was significantly associated with a shorter stay, superior disease‐free survival (DFS) but longer operation time compared to ORLR. Comparison between LRLR versus LLR demonstrated that patients undergoing LRLR were significantly older, had smaller tumors, longer operation time and decreased frequency of Pringle’s maneuver applied. There was no difference in other key perioperative outcomes.ConclusionThe results of this study demonstrate that in highly selected patients; LRLR for rHCC is feasible and safe. LRLR was associated with a shorter hospitalization but longer operation time compared to ORLR. Moreover, other than a longer operation time, LRLR was associated with similar perioperative outcomes compared to LLR for primary HCC.
East meets West: Shadow coaching to support online reflective practice
Authors: Byszewski Anna , Fraser Amy , Lochnan Heather 
Published: October 2018

Objectives A structured, reflection-based electronic portfolio program (ePortfolio), with novel faculty development initiative, involving ‘shadow coaches’, was shared with the newly formed Ottawa-Shanghai Joint School of Medicine (OSJSM). OSJSM is a partnership between Shanghai Jiao Tong University and the University of Ottawa. As the world’s first Sino-Canadian Joint Medical School, OSJSM introduced North American undergraduate medical curriculum to China. ‘Shadow coaching’ involved trans-Pacific pairing of coaches, supplemented by local faculty development.
Framework (a) Pre-implementation: The well-established online ePortfolio platform at the University of Ottawa was mirrored at OSJSM. University of Ottawa ePortfolio coaches were recruited to serve as shadow coaches to their OSJSM counterparts. Shadow coaches provided mentoring and resources while maintaining awareness of cross-cultural issues. Faculty development consisted of face-to-face faculty development in Shanghai, several online synchronous sessions, and familiarization of University of Ottawa coaches with the Chinese medical education system. (b) Description/Components: This intervention, introduced in 2016–2017, involved five University of Ottawa shadow coaches paired with five OSJSM ePortfolio coaches. Student reflection encourages open frank discussion which is a new paradigm for Chinese students and faculty. Shadow coaches were encouraged to challenge new OSJSM coaches to widely explore physician roles and competencies.
Results Initial results indicate that the experience served to effectively develop OSJSM coaches’ skills as evidenced by shadow coaches’ review of anonymized OSJSM student reflective writing.
Conclusions Our project describes a novel tool using shadow coaching for faculty development for a cross-cultural partnership. Similar approaches can be utilized for culturally-sensitive long-distance faculty development.
A hybridization of differential evolution and monarch butterfly optimization for solving systems of nonlinear equations
Authors: Ibrahim Abdelmonem M. , Tawhid Mohamed A. 
Published: October 2018

Abstract
In this study, we propose a new hybrid algorithm consisting of two meta-heuristic algorithms; Differential Evolution (DE) and the Monarch Butterfly Optimization (MBO). This hybrid is called DEMBO. Both of the meta-heuristic algorithms are typically used to solve nonlinear systems and unconstrained optimization problems. DE is a common metaheuristic algorithm that searches large areas of candidate space. Unfortunately, it often requires more significant numbers of function evaluations to get the optimal solution. As for MBO, it is known for its time-consuming fitness functions, but it traps at the local minima. In order to overcome all of these disadvantages, we combine the DE with MBO and propose DEMBO which can obtain the optimal solutions for the majority of nonlinear systems as well as unconstrained optimization problems. We apply our proposed algorithm, DEMBO, on nine different, unconstrained optimization problems and eight well-known nonlinear systems. Our results, when compared with other existing algorithms in the literature, demonstrate that DEMBO gives the best results for the majority of the nonlinear systems and unconstrained optimization problems. As such, the experimental results demonstrate the efficiency of our hybrid algorithm in comparison to the known algorithms.
Highlights This paper proposes a new hybridization of differential evolution and monarch butterfly optimization. Solve system of nonlinear equations and unconstrained optimization problem. The efficiency and effectiveness of our algorithm are provided. Experimental results prove the superiority of our algorithm over the state-of-the-arts.
KURT GÖDEL’S FIRST STEPS IN LOGIC: FORMAL PROOFS IN ARITHMETIC AND SET THEORY THROUGH A SYSTEM OF NATURAL DEDUCTION
Authors: VON PLATO JAN 
Published: October 2018

AbstractWhat seem to be Kurt Gödel’s first notes on logic, an exercise notebook of 84 pages, contains formal proofs in higher-order arithmetic and set theory. The choice of these topics is clearly suggested by their inclusion in Hilbert and Ackermann’s logic book of 1928, the Grundzüge der theoretischen Logik. Such proofs are notoriously hard to construct within axiomatic logic. Gödel takes without further ado into use a linear system of natural deduction for the full language of higher-order logic, with formal derivations closer to one hundred steps in length and up to four nested temporary assumptions with their scope indicated by vertical intermittent lines.
Communal Orientation Predicting Flourishing of Married Individuals: Mediation of Emotion Expressivity
Authors: Fahd Samar , Hanif Rubina 
Published: October 2018

AbstractExpression of emotions may arbitrate the connections between communal orientation and psychological flourishing of married individuals that may lead to optimal functioning within a marital relationship. By using cross-sectional research design, the present study measures multiple dimensions of psychological flourishing (relationship and individual) in conjunction with communal orientation and emotion expressivity. Among married individuals from Pakistan aged 20–80 years, the authors examined the mediating effect of each spouse's emotional expression (positive, negative, and impulse strength) on the association between communal orientation and psychological flourishing. Findings highlight that communal orientation significantly predicts psychological flourishing. Positive Communal Orientation positively predicts relationship dimension as well as the Individual dimension of psychological flourishing. On the other hand, Negative Communal Orientation negatively predicts the Relationship dimension of psychological flourishing. However, Negative Communal Orientation positively predicts the Individual dimension of psychological flourishing. Furthermore, positive expressivity, negative expressivity and impulse strength significantly mediate the relationship between communal orientation and psychological flourishing. Moreover, gender differences were also found in the exercise of communal orientation and level of flourishing among husbands and wives. The evidence from the present study can be utilised to design relationship measure that can capture all the ingredients of optimal functioning of marital relationship.
The impact of parenthood on risk of registration for alcohol use disorder in married individuals: a Swedish population-based analysis
Authors: Kendler Kenneth S. , Larsson Lönn Sara , Salvatore Jessica E. , Sundquist Jan , Sundquist Kristina 
Published: October 2018

AbstractBackgroundAlthough being married with children is associated with a reduced rate of alcohol use disorder (AUD), is this finding independent of a marital effect, different in mothers and fathers and potentially causal in effect.MethodsUsing Cox proportional hazards, we examined, in 1 252 237 married individuals, the association between a resident younger and older child and risk for AUD registration in national medical, criminal, and pharmacy registers. Using logistic regression, we analyzed, in 600 219 parents, within-person models comparing risk for AUD prior to first pregnancy v. with young children. We examined whether risk for AUD in 1302 parents after a first spousal AUD registration was reduced by having a young resident child.ResultsCompared with childless married individuals, resident younger children were associated with a reduced risk for AUD in mothers [hazard ratio (HR) 0.36, 95% confidence interval 0.31–0.41] and fathers (HR 0.66, 0.60–0.73). The reduced risk was attenuated but still significant for older children. Within-person models confirmed the protective effect of young children in mothers [odds ratio (OR) 0.49, 0.30–0.80] but yielded inconclusive results in fathers (OR 0.85, 0.58–1.25). After a first spousal registration for AUD, a resident young child was associated with a substantial reduction in risk for mothers and a weaker marginal effect in fathers.ConclusionIn married individuals, resident children are associated with a reduction in basal risk for AUD which is stronger in mothers than fathers and with younger v. older children. This effect is also evident during high-risk periods. In mothers, our results are consistent with a largely causal effect.
Bridging the divide: the adjustment and decision-making experiences of people with dementia living with a recent diagnosis of cancer and its impact on family carers
Authors: McWilliams Lorna , Swarbrick Caroline , Yorke Janelle , Burgess Lorraine , Farrell Carole , Grande Gunn , Bellhouse Sarah , Keady John 
Published: October 2018

AbstractThe risk of living with dementia and, separately, cancer, increases exponentially with age. However, to date, there is a paucity of research investigating the experiences of people living with both these conditions. This study used semi-structured interviews to explore the decision-making and treatment options for people who live with both dementia and cancer. In total, ten people living with both dementia and cancer (aged 39–93 years) and nine family carers were interviewed. Braun and Clarke's approach to thematic analysis was used together with framework matrices to organise the data. In this article four sequential and descriptive themes are presented. ‘Reaching a diagnosis of cancer’ describes the vital role that family carers play in encouraging the person with dementia to seek an explanation for their presenting (undiagnosed cancer) symptoms to their general practitioner. ‘Adjusting to the cancer diagnosis when living with dementia’ outlines a variety of emotional and practical responses to receiving news of the diagnosis. ‘Weighing up the cancer treatment options’ highlights the different decisions and circumstances that family carers and people living with both dementia and cancer are faced with post-diagnosis. ‘Undergoing cancer treatment’ shares the finding that cancer treatment decision-making was not straightforward and that people living with both dementia and cancer would often forget about their cancer and what procedures they had been through.
Plato, Aristotle, Paris and Helen at the Last Judgement: the legacy ofAudi tellus, audi magni maris limbus
Authors: BREWER CHARLES E. 
Published: October 2018

ABSTRACTThe twenty-four stanzaabecedarium, beginningAudi tellus, audi magni maris limbus(Montpellier, Bibliothèque de la ville, 6), stands at the beginning of a long tradition of similar songs of judgement. A closer study of the sources provides for a deeper understanding of the transformation of the original song into a versicle to theLibera meand by the thirteenth century the first two lines of the song were transformed into the beginning of an unusual litany asking ‘Ubi sunt’, which was again most often described in the rubrics as a trope to theLibera me, particularly on All Souls Day. Here, however, an unusual and varying cast of characters enter the text of the song and the liturgy, including classical philosophers, such as Plato and Aristotle, historic figures, such as Paris and Helen, and even the biblical heroes Samson and King David. By the later Middle Ages, the trope had been further transformed into a devotional song and was especially prominent in sources associated with the cloisters of theDevotio modernaand later in polyphonic settings by Caspar Othmayr, Jacobus Gallus and Orlandus Lassus.
In conversation with Massimiliano Gioni
Authors: Tansella C. 
Published: October 2018

AbstractLately on these pages, a discussion is going on over the opportunity of the use of the definition ‘outsider’. Especially in the USA, it is judged as demeaning, discriminating and inappropriate, whilst in Europe, it is used in a much more unconcerned way. Mr Gioni curator of numerous international exhibitions including Manifesta 5 (2004), the 4th Berlin Biennale (2006), the 8th Gwangju Biennale (2010) and the 55th Venice Biennale (2013) shares his perspective on contemporary culture and self-taught art.
A proposal for using the ratio of attempted to completed suicides across several countries worldwide
Authors: Blasco-Fontecilla H. , Artieda-Urrutia P. , de Leon J. 
Published: October 2018

AbstractCompleted suicide (CS) is a leading cause of death worldwide and its rates are available for most developed countries. On the other hand, attempted suicide (AS) is a risk factor for CS but there are limited data on its rates in various countries. In constructing a ratio for AS/CS rates, most would agree that for CS, the denominator should be the annual suicide rate (per 100 000). As for the ratio's numerator (AS) per 100 000, there are three possible calculations: (1) annual prevalence from population surveys, (2) annual prevalence from national clinical registers or (3) lifetime prevalence from population surveys. We think that the first possibility would probably be the best choice but, unfortunately, surveys providing the annual prevalence of AS are lacking for most countries. Annual prevalence from national registers is also lacking for most countries and is contaminated by under-reporting. Therefore, in this editorial, we are left with only the last option, a ratio for lifetime prevalence of AS (per 100 000) divided by annual rate of CS (per 100 000). This ratio for AS/CS rates appears to differ substantially across countries worldwide but presents no big regional differences other than two remarkable exceptions, one per continent. In Europe, Spain and France had greater ratios (174.4 and 152.5, respectively) than Italy (64.1). In Asia/Pacific, New Zealand has a higher ratio (345.9) compared with China (75.8) and Japan (76.9). The ratio for AS/CS rates could be a good index for implementing evidence-informed decision-making regarding suicidal behaviour (SB) among health service managers, and for helping them in the allocation of health resources for the prevention of SB.