bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bilateral fibrodysplasia ossificans affecting the masticatory muscles and causing irreversible trismus in a domestic shorthair cat
Authors: Guzu Michel , Gaillot Hugues A , Rosati Marco , Nicolier Alexandra , Hennet Philippe R 
Published: April 2019

Case summary An 8-year-old spayed female domestic shorthair cat was referred for trismus of progressive onset, which had started at least 1 month previously. The patient presented with weakness, anorexia, chronic bilateral purulent nasal discharge and concurrent reduced nasal airflow. Upon physical examination, painful mouth opening, bilateral swelling of the temporal areas, with an inability to open and close the mouth completely, were apparent. A vertical mandibular range of motion (vmROM) of 22 mm was noted. Complete blood count, biochemistry, electrolytes and various serology tests were unremarkable. CT revealed multiple mineralised lesions within the masticatory muscles. Histopathological features were consistent with those seen in the human disease fibrodysplasia ossificans progressiva (FOP). Supportive treatment did not improve the vmROM, eventually resulting in a 13 mm open bite, and total inability to close and open the mouth. Cardiac arrest occurred at the induction of an anaesthesia procedure aiming to perform tracheostomy and nasal lavage. Despite emergency tracheotomy and cardiac resuscitation, humane euthanasia was elected by the owners. Post-mortem molecular investigations highlighted a heterozygous deletion, compatible with a splicing site mutation in ACVR1, which is also associated with FOP in humans. Relevance and novel information This is the first report in the veterinary literature of FOP-like disease selectively affecting the masticatory muscles. This condition is associated with a poor prognosis, as no medical or surgical treatment has currently proven to be of any prophylactic or curative benefit. Although rare, FOP-like disease should be included in the differential diagnosis of trismus in the cat. Any further muscle injury should be avoided.
Overall survival and tumor recurrence after surgical resection for primary malignant chest wall tumors: a single-center, single-surgeon experience
Authors: Shah Aalap C , Komperda Kazimierz W , Mavanur Arun A , Thorpe Steven W , Weiss Kurt R , Goodman Mark A 
Published: April 2019

Background and objectives: Malignant primary chest wall tumors (PCWTs) comprise a rare group of thoracic tumors with unique anatomical considerations, and experience with wide surgical resection is limited to specialty referral centers and specific diagnoses. We investigated the tumor recurrence and overall survival (OS) for patients with a variety of PCWTs diagnoses at our institution. Methods: From 1991 to 2010, patients with malignant PCWT undergoing wide surgical resection for curative intent under a single surgeon were reviewed. Diagnosis and grade (if applicable) of surgical pathology, along with patient demographics, neoadjuvant chemotherapy or radiation therapy, and outcomes (complications, recurrence, and OS) at follow-up were analyzed. Results: One hundred fifteen patients were included in the study. The most common tumor diagnoses included pleomorphic sarcoma and liposarcoma. Negative margins were achieved in 70 (74%) of cases. Postoperative complications were reported in 21 (20%) cases. The 5-year survival rate was 54%, while the 10-year survival rate was 29%. The local and distant recurrence rates were 50% and 38%, respectively. OS was significantly less in patients with any recurrence ( p < 0.001) but not significantly different between pathology grades ( p = 0.28). Conclusions: Wide resection for malignant PCWT is feasible when undertaken for a heterogenous group of diagnoses.
Malignant tumors of the shoulder girdle: Surgical and functional outcomes
Authors: Öztürk Recep , Arıkan Şefik Murat , Toğral Güray , Güngör Bedii Şafak 
Published: April 2019

Background: Large resection and reconstruction of the malignant tumors of the shoulder girdle are used to provide maximum protection of the soft tissues with sufficient surgical margin. However, these have their own difficulties. The goals of this study were to review demographic data of 187 patients diagnosed with the malignant tumors located around shoulder between 2001 and 2016 in our clinic, to evaluate the functional outcomes and surgical outcomes, and to classify the resection methods according to new classification systems. Methods: There were 187 patients (108 male and 79 female) and the mean age at surgery was 47.9 (range 2–87). Fifty-one of these patients underwent biopsy only: 8 partial/total claviculectomy, 10 partial/total scapulectomy, 80 proximal humeral resection, 5 total humeral resection, 6 shoulder girdle resection, and 13 amputations. Eighty-six had prosthetic implants, five had fibula transpositions, and one had a massive homologous bone graft. Seventy-one of the 136 patients were followed for an average of 40.3 months. Results: When the bone resections were evaluated, the best results were obtained while the rotator cuff function is preserved in glenoid preserving partial scapulectomy, partial/total claviculectomy, and proximal humerus intercalary resection. In total, scapulectomy and proximal/total humeral resection operations’ results were moderate because of partial or total injury of the abductor mechanism. Conclusions: As a result, malignant tumors of the shoulder girdle and soft tissue can be treated with limb-sparing surgery procedures. Reconstructive procedures and reconstructive methods such as prosthetic replacement, auto-allograft, and soft tissue reconstructions should be specified in each case. These resection and reconstruction methods are reliable and applicable procedures for local tumor control, pain control, and functional outcomes. More rarely, amputation/disarticulation can be performed.
Parenting stress in mothers of children with congenital hand or foot differences and its effect on the surgical decision-making for their children
Authors: Kim Jihyeung , Gong Hyun Sik , Kim Hong Seok , Seok Hyun Sik , Oh Sohee , Baek Goo Hyun 
Published: April 2019

Background: The main purposes of this study were to assess the levels of parenting stress in the mothers of children with congenital hand or foot differences and to evaluate the effects of this stress on the preferred roles of mothers in surgical decision-making for their children. Methods: This study included 89 mothers of children with polydactyly of the hand, polydactyly of the foot, a hypoplastic thumb, or macrodactyly. The parenting stress level was assessed using the Parenting Stress Index–Short Form (PSI-SF). Additionally, the mothers were requested to indicate their preferred and retrospectively perceived levels of involvement in surgical decision-making for their children using the Control Preferences Scale, which is comprised of five levels ranging from fully active to fully passive. Results: The average PSI-SF scores were 73.9, and 15 mothers (17%) had a clinically significant level of stress (PSI-SF ≥ 90). In the mothers of children with polydactyly of the foot, the PSI score was associated with the preferred role in surgical decision-making. Conclusion: The assessment of parenting stress levels in the mothers of children with congenital hand or foot differences can play an important role in the screening of candidates who require psychiatric treatment or support. An evaluation of the PSI in mothers of children with congenital hand or foot differences may aid physicians to modify their style of decision-making based on the preferred role of the mother. Level of evidence: Level IV Therapeutic study.
Dissociative identity disorder: validity and use in the criminal justice system
Authors: Paris Joel 
Published: April 2019

SUMMARYThis review examines whether the diagnosis of dissociative identity disorder (DID) could be used to support a defence of ‘not guilty by reason of insanity’ (NGRI, or the insanity defence). The problem is that DID has doubtful validity and can easily be malingered. However, the diagnosis is listed in standard psychiatric manuals. If accepted as valid, DID would have problematic forensic implications.LEARNING OBJECTIVESAfter reading this article you will be able to:
•understand the history of the DID diagnosis•evaluate the validity of the DID diagnosis•appreciate, from case law, use of DID in support of an insanity defence.DECLARATION OF INTERESTNone.
Genetic Alterations Detected in Cell-Free DNA Are Associated With Enzalutamide and Abiraterone Resistance in Castration-Resistant Prostate Cancer
Authors: Torquato Samantha , Pallavajjala Aparna , Goldstein Alexa , Valda Toro Patricia , Silberstein John L. , Lee Justin , Nakazawa Mary , Waters Ian , Chu David , Shinn Daniel , Groginski Taylor , Hughes Robert M. , Simons Brian W. , Khan Hamda , Feng Zhaoyong , Carducci Michael A. , Paller Channing J. , Denmeade Samuel R. , Kressel Bruce , Eisenberger Mario A. , Antonarakis Emmanuel S. , Trock Bruce J. , Park Ben H. , Hurley Paula J. 
Published: April 2019

PURPOSE Androgen receptor ( AR) gene alterations, including ligand-binding domain mutations and copy number (CN) gain, have yet to be fully established as predictive markers of resistance to enzalutamide and abiraterone in men with metastatic castration-resistant prostate cancer (mCRPC). The goal of this study was to validate AR gene alterations detected in cell-free DNA (cfDNA) as markers of enzalutamide and abiraterone resistance in patients with mCRPC. METHODS Patients with mCRPC (N = 62) were prospectively enrolled between 2014 and 2018. Blood was collected before therapies—enzalutamide (n = 25), abiraterone (n = 35), or enzalutamide and abiraterone (n = 2) —and at disease progression. We used deep next-generation sequencing to analyze cfDNA for sequence variants and CN status in AR and 45 additional cancer-associated genes. Primary end points were prostate-specific antigen response, progression-free survival (PFS), and overall survival (OS). RESULTS Elevated tumor-specific cfDNA (circulating tumor DNA) was associated with a worse prostate-specific antigen response (hazard ratio [HR], 3.17; 95% CI, 1.11 to 9.05; P = .031), PFS (HR, 1.76; 95% CI, 1.03 to 3.01; P = .039), and OS (HR, 2.92; 95% CI, 1.40 to 6.11; P = .004). AR ligand-binding domain missense mutations (HR, 2.51; 95% CI, 1.15 to 5.72; P = .020) were associated with a shorter PFS in multivariable models. AR CN gain was associated with a shorter PFS; however, significance was lost in multivariable modeling. Genetic alterations in tumor protein p53 (HR, 2.70; 95% CI, 1.27 to 5.72; P = .009) and phosphoinositide 3-kinase pathway defects (HR, 2.62; 95% CI, 1.12 to 6.10; P = .026) were associated with a worse OS in multivariable models. CONCLUSION These findings support the conclusion that high circulating tumor DNA burden is associated with worse outcomes to enzalutamide and abiraterone in men with mCRPC. Tumor protein p53 loss and phosphoinositide 3-kinase pathway defects were associated with worse OS in men with mCRPC. AR status associations with outcomes were not robust, and additional validation is needed.
Virologic failure and HIV drug resistance on simplified, dolutegravir-based maintenance therapy: Systematic review and meta-analysis
Authors: Wandeler Gilles , Buzzi Marta , Anderegg Nanina , Sculier Delphine , Béguelin Charles , Egger Matthias , Calmy Alexandra 
Published: April 2019

Background: Dolutegravir-containing maintenance therapy is a promising simplification strategy for virologically suppressed HIV-infected individuals. However, most of the available data to inform this strategy come from small, uncontrolled studies. We estimated the proportion of HIV-infected patients experiencing virological failure (VF) and developing drug resistance on dolutegravir (DTG)-based maintenance therapy. Methods: We searched Medline, Embase, Cochrane Central, Web of Science, and conference abstracts for studies assessing VF on DTG-based maintenance therapy. Studies including ≥5 adults with an undetectable viral load on antiretroviral therapy (ART) who switched to a DTG-based mono- or dual therapy were included. Pooled proportions of VF were estimated using random-intercept logistic meta-regression and acquired drug resistance mutations described for each strategy. Results: Of 1719 studies considered, 21 met our selection criteria, including seven interventional and 14 observational studies. Eight studies including 251 patients assessed VF on DTG monotherapy and fourteen studies including 1670 participants VF on dual therapy. The participant’s median age ranged from 43 to 63 years, their median nadir CD4 count from 90 to 399 cells/µl, and 27.6% were female. The proportion of participants experiencing VF on DTG-monotherapy was 3.6% (95% confidence interval [CI] 1.9-6.7) at 24 weeks and 8.9% (95% CI 4.7-16.2) at 48 weeks. Resistance mutations developed in seven (3.6%) participants on DTG-monotherapy. Among patients on dual therapy, ten (0.7%, 95% CI 0.4-1.3) experienced VF by 48 weeks and none developed resistance to DTG. In adjusted analyses, VF at 24 weeks was less likely on dual therapy than on monotherapy (adjusted odds ratio: 0.10, 95% CI 0.03-0.30). Conclusions: Whereas VF is relatively common on DTG maintenance monotherapy, DTG-based dual therapy appears to be a promising simplification strategy for individuals with a suppressed HIV viral load on triple-ART.
Simulação geoestatística e numérica para previsão da eficiência da remediação por oxidação química in situ
Authors: Teramoto Elias Hideo , Pede Marco Aurélio Zequim , Chang Hung Kiang 
Published: April 2019

A eficiência dos sistemas de remediação, como a oxidação química in situ (ISCO) é fortemente restringida pela presença de heterogeneidades nos valores de permeabilidade. As incertezas relacionadas à presença de heterogeneidades nos aquíferos em relação aos sucessos dos sistemas de remediação podem ser determinadas por intermédio de simulações estocásticas, embora tal metodologia não tenha sido empregada comumente para problemas envolvendo ISCO. Em decorrência deste cenário, foi objetivo deste trabalho desenvolver um procedimento metodológico para prever a eficiência da técnica de remediação por oxidação química in situ a partir do emprego de simulações estocásticas e simulações numéricas de fluxo e transporte. No caso hipotético simulado, foram gerados 30 campos randômicos tridimensionais equiprováveis de condutividade hidráulica e a eficiência da remediação foi testada em todos estes cenários. Os resultados indicam que o sistema de remediação proposto será ineficiente em 100% dos casos, invocando a necessidade de alterações no projeto inicial, tais como número de pontos e tempo de injeção. O elevado grau de incerteza identificado no cenário de contaminação admitido sugere ainda que novas investigações sejam realizadas para redução de incertezas e previsões mais realistas.
MITOLOGIE POWIEŚCIOPISARSTWA HISTORYCZNEGO (NA WYBRANYCH PRZYKŁADACH Z LITERATURY POLSKIEJ PO 1945 ROKU)
Authors: Tomczok Paweł 
Published: April 2019

Artykuł jest próbą ujęcia wizerunków, jakie zaprezentowali w wywiadach, posłowiach czy wstępach, a także w esejach powieściopisarze historyczni okresu powojennego. Jako materiał ilustracyjny w artykule przytoczone zostały wypowiedzi Teodora Parnickiego, Hanny Malewskiej, Antoniego Gołubiewa, Elżbiety Cherezińskiej oraz Marcina Wolskiego. Ich wypowiedzi zostały ujęte w ramy czterech płaszczyzn, które definiowały możliwe pozycje, jakie zająć mógł powieściopisarz historyczny, gdy opowiadał o swojej pracy pisarskiej. Te cztery płaszczyzny określają mitologię powieściopisarza historycznego, a także możliwości budowania swoistego antymitu opartego na negacji podstawowych wyznaczników literackiego mówienia o przeszłości.
REKONFIGURACJA. DMITRIJ GŁUCHOWSKI NA GRUNCIE REALIZMU
Authors: Przybysz Anna 
Published: April 2019

Niniejszy artykuł stanowi próbę usytuowania ostatniej jak dotąd powieści Dmitrija Głuchowskiego – Tekst – na tle wcześniejszej twórczości pisarza. Autorka artykułu zwraca uwagę na nieustanną ewolucję twórczą rosyjskiego artysty, a także na szeroki wachlarz jego umiejętności warsztatowych. Tekst to powieść psychologiczna, stanowiąca udany mariaż klasycznych wątków, motywów czy problemów z tym, co aktualne, mocno związane z postępem techniki i zmianami w sposobie postrzegania rzeczywistości. Autor Tekstu jawi się jako baczny obserwator otaczającego świata, który w swej pierwszej realistycznej powieści dokonuje trafnej diagnozy kondycji współczesnego człowieka.
МИФ, МИРОВОЕ ВРЕМЯ И МОДЕЛИ ПРОСТРАНСТВА В ПОСТМОДЕРНИСТСКИХ ПРОИЗВЕДЕНИЯХ В. ПЕЛЕВИНА
Authors: Dohnal Josef , Abaganova Assel 
Published: April 2019

В данной статье рассматривается одна из тем творчества Виктора Пелевина – миф. Исследуется миф с учетом всех его форм, вариаций и трансформаций от классической мифологии (Бог Ра), современной социальной, политической до вампирской мифологии. Миф, в силу тематизированной возможности многократной повторяемости, модифицирует категорию времени в развертывании сюжета в произведениях постмодернистов. В статье изучается проблема определения статуса и роли мифа в творчестве В. Пелевина. Делается вывод о том, что миф является фундаментальной категорией многих романов Пелевина. Писатель использует в романах такую особенность своей поэтики, как «неомифологизм» – межтекстовое заимствование некоторых элементов архаических структур мифов или мета-историй. Объективное историческое время заменяется мифологическим временем, поскольку действия и события представлены в романе как прототипы.
PAVOL STRAUSS – A GENIUS OUTSIDER
Authors: Žilka Tibor 
Published: April 2019

The aim of this paper regarding Pavol Strauss‘ Literary Work in the Central European Context is to introduce Pavol Strauss as a man and a writer, who was with his heart and soul a Central European. He had a strong bound to this territory spatially and temporally. At first, he was chased as a Jew, later on in the age of 30 he converted into Catholic. During the period of Stalinism, they considered him a second-class citizen, and he was wrongly called the clero-fascists however he was a believing Catholic. He was literally active in the second half of the 1930s, when he published two poetic collections in German. His poems in German were influenced by avant-garde which he became in touch with in Prague – its literary atmosphere defined Pavol Strauss’ literary experiments and further orientation. When speaking of Prague, also think of Franz Kafka, Franz Werfel and, of course, Reiner Maria Rilke. From the literary point of view, Pavol Strauss with his literary essays reached the highest level along with famous authors (R. Musil, K. Kraus, H. Broch). For his 82 years long life, Pavol Strauss cured many patients and left rare books of a unique philosophical dimension.
CZYTANIE ŚWIATA. HENRYK WANIEK – PISARZ, MALARZ, OUTSIDER
Authors: Ćwiklak Kornelia 
Published: April 2019

Niniejszy tekst poświęcony został twórczości literackiej Henryka Wańka, artysty o niezwykle bogatym i spójnym dorobku literackim i malarskim, który scala idea odkrywania duchowego podłoża rzeczywistości. Dla właściwego zrozumienia jego sztuki ukazano ją w kontekście śląskiego undergroundu artystycznego lat sześćdziesiątych i siedemdziesiątych. Stawiam tezę, że Waniek łączy w swej twórczości (pozornie) przeciwstawne modele: outsiderski i powinnościowy, przy czym kierunek i zakres tego drugiego jest skutkiem autonomicznych decyzji twórczych. Pisarz z czasem coraz mocniej opowiada się po stronie modelu artysty będącego strażnikiem pamięci. Jednak istotne pozostaje nadal traktowanie sztuki jako drogi wtajemniczenia. Obydwie antagonistyczne postawy spotykają się w figurze outsidera, podążającego własną drogą przez Śląsk, który artysta uznał za centralne miejsce swojej twórczości.
Survey on teaching experiences in cinematography
Authors: Slansky Peter C. , Richthofer Katrin 
Published: April 2019

Abstract
In a recent survey, 125 cinematographers were asked to describe their teaching experiences. This article summarises their responses to eight question modules. The top three teaching topics are lighting design, artistic use of the lens and picture composition for film and television cameras. From all actual technological developments, digital colour grading is seen as having the greatest impact on teaching cinematography, as well as on cinematography itself. While almost all teachers use digital cameras for their daily work, about 40% still also use traditional film in their courses. Even in the digital age, the traditional film helps draw the students’ attention away from technical options towards precision and accuracy in the actual recording of scenes.
Identification of Powdery Mildew Blumeria graminis f. sp. tritici Resistance Genes in Selected Wheat Varieties and Development of Multiplex PCR
Authors: Tomkowiak Agnieszka , Skowrońska Roksana , Weigt Dorota , Kwiatek Michał , Nawracała Jerzy , Kowalczewski Przemysław Łukasz , Pluta Mateusz 
Published: April 2019

AbstractThe aim of the study was to identify thePm2, Pm3a, Pm4bandPm6genes and to develop multiplex PCR reaction conditions to reduce time and limit analysis costs. The following molecular markers were used for gene identification:Xcfd81, Whs350andXgwm205(forPm2),Pm3a(forPm3a),STS_241andXgwm382(forPm4b),NAU/BCDSTS 135-2(forPm6). Plant material consisted of 7 popular European wheat varieties from the wheat collection at the Department of Genetics and Plant Breeding of the Poznań University of Life Sciences. The field experiment was established in 2017 and 2018 on 10 m2plots in a randomized complete block design in three replicates in the Dłoń Agricultural Experimental Farm of the Poznań University of Life Sciences (51°41’23.835”N 017°4’1.414”E). The analyses demonstrated that the accumulation of all identifiedPmgenes was found in the Assosan variety. The accumulation of thePm2, Pm4bandPm6genes was found in Atomic, Bussard, Lear, Sparta, Tonacja and Ulka varieties. The work also involved developing multiplex PCR conditions forXcfd81andSTS_241andXcfd81andXgwm382primer pairs, allowing the simultaneous identification of thePm2andPm4bgenes.
The effects of likes on public opinion perception and personal opinion
Authors: Porten-Cheé Pablo , Eilders Christiane 
Published: April 2019

Abstract
Drawing on the spiral of silence theory and heuristic information processing, we contend that individuals use likes as sources for assessing public opinion. We further argue that individuals may even adapt their personal opinions to the tenor reflected in those cues. The assumptions were tested using data from an experiment involving 501 participants, who encountered media items on two issues with or without likes. The findings show that respondents inferred public opinion from the media bias if it was supported by likes, however, only in cases of high levels of fear of social isolation. Respondents further adapted their personal opinion to the media bias if it was supported by likes.
Inadequate Prosthetic Rehabilitation Caused by Fibrous and Bone Hyperplasia of Maxilla – Case Report
Authors: Gačić Bojan , Stojčev-Stajčić Ljiljana , Djinić Ana , Kalanović Milena , Ilić Branislav , Rebić Kristina 
Published: April 2019

Summary
Normal bone healing after tooth extraction includes the following steps: blood clot forming, granulation, bone forming and final bone reorganization. In clinical settings connective tissue infiltration of extraction socket can result in fibrous scar formation rather than bone healing. Local and systemic factors seem to be major contributors to the occurrence of erratic socket healing. The aim of this case report was to describe oral-surgery treatment of a patient with inadequate bone and soft supportive tissue for prosthetic rehabilitation. Surgical procedure and recovery are presented, including final complete denture rehabilitation.