bluuebunny/crossref_metadata_2025_split huggingface dataset:
IXA Honorary Member Lecture, 2017: The long and winding road to tolerance
Authors: Sykes Megan 
Published: June 2018

AbstractThe last 15 years or so have seen exciting progress in xenotransplantation, with porcine organ grafts surviving months or even years in non‐human primates. These advances reflect the application of new scientific knowledge, improved immunosuppressive agents, and genetic engineering. The field has recently enjoyed a renaissance of interest and hope, largely due to the exponential increase in our capacity to genetically engineer porcine source animals. However, immune responses to xenografts are very powerful and widespread clinical application of xenotransplantation will depend on the ability to suppress these immune responses while preserving the capacity to protect both the recipient and the graft from infectious microorganisms. Our work over the last three decades has aimed to engineer the immune system of the recipient in a manner that achieves specific tolerance to the xenogeneic donor while preserving otherwise normal immune function. Important proofs of principle have been obtained, first in rodents, and later in human immune systems in “humanized mice” and finally in non‐human primates, demonstrating the capacity and potential synergy of mixed xenogeneic chimerism and xenogeneic thymic transplantation in tolerizing multiple arms of the immune system. Considering the fact that clinical tolerance has recently been achieved for allografts and the even greater importance of avoiding excessive immunosuppression for xenografts, it is my belief that it is both possible and imperative that we likewise achieve xenograft tolerance. I expect this to be accomplished through the availability of targeted approaches to recipient immune conditioning, understanding of immunological mechanisms of tolerance, advanced knowledge of physiological incompatibilities, and the availability of inbred miniature swine with optimized use of genetic engineering.
Phylogeny of the Caninae (Carnivora): Combining morphology, behaviour, genes and fossils
Authors: Zrzavý Jan , Duda Pavel , Robovský Jan , Okřinová Isabela , Pavelková Řičánková Věra 
Published: June 2018

AbstractPhylogenetic relationships among 36 Recent and 42 extinct species of the Caninae (Canidae) were analysed, based on 360 morphological, developmental, ecological, behavioural and cytogenetic characters and 24 mitochondrial and nuclear markers. Primary phylogenetic analyses were accompanied by experimental analyses based on various combinations of data partitions and taxon samples. Leptocyon was recovered as a paraphyletic stem lineage of the Caninae; monophyly/paraphyly of the fox‐like canids (Vulpini) remains uncertain; Urocyon and Metalopex form a clade, possibly sister to all non‐Leptocyon canids; Otocyon, Nyctereutes and Nurocyon form a clade; dog‐like canids (Canini) are monophyletic (with South American Cerdocyonina and Afro‐Holarctic Canina); all South American hypercarnivores (Canis gezi, Protocyon, Speothos, Theriodictis) form a clade, close to Chrysocyon and Dusicyon; Canis arnensis, C. ferox, C. thooides, C. lepophagus and Eucyon spp. are basal to the Canina; Lycaon is an isolated African hypercarnivore; Cuon and its relatives (Xenocyon, possibly also Canis antonii, C. falconeri and Cynotherium) form a clade close to Canis s. str.; C. edwardii–C. etruscus–C. mosbachensis–C. palmidens–C. variabilis and hypercarnivorous Canis armbrusteri–C. dirus clades belong to Canis s. str. As the highly homoplastic morphological characters connected to dietary biology are the prominent characters available for the key fossil species, we conclude that macroevolutionary and palaeoecological analyses of the extinct and extant Caninae were to some extent compromised by the phylogenies used.
Towards a complex systems approach in sports injury research: simulating running-related injury development with agent-based modelling
Authors: Hulme Adam , Thompson Jason , Nielsen Rasmus Oestergaard , Read Gemma J M , Salmon Paul M 
Published: June 2018

ObjectivesThere have been recent calls for the application of the complex systems approach in sports injury research. However, beyond theoretical description and static models of complexity, little progress has been made towards formalising this approach in way that is practical to sports injury scientists and clinicians. Therefore, our objective was to use a computational modelling method and develop a dynamic simulation in sports injury research.MethodsAgent-based modelling (ABM) was used to model the occurrence of sports injury in a synthetic athlete population. The ABM was developed based on sports injury causal frameworks and was applied in the context of distance running-related injury (RRI). Using the acute:chronic workload ratio (ACWR), we simulated the dynamic relationship between changes in weekly running distance and RRI through the manipulation of various ‘athlete management tools’.ResultsThe findings confirmed that building weekly running distances over time, even within the reported ACWR ‘sweet spot’, will eventually result in RRI as athletes reach and surpass their individual physical workload limits. Introducing training-related error into the simulation and the modelling of a ‘hard ceiling’ dynamic resulted in a higher RRI incidence proportion across the population at higher absolute workloads.ConclusionsThe presented simulation offers a practical starting point to further apply more sophisticated computational models that can account for the complex nature of sports injury aetiology. Alongside traditional forms of scientific inquiry, the use of ABM and other simulation-based techniques could be considered as a complementary and alternative methodological approach in sports injury research.
Research on electronic structures and optical properties of zinc-blende aluminum nitride doped with transition metals from first-principles
Authors: Lu Xuefeng , Zhao Tingting , Ren Junqiang , Guo Xin , Yan Xiaobin , La Peiqing 
Published: June 2018

Electronic structures and optical properties of zinc-blende aluminum nitride doped with transition metals are investigated. Lu-doped system possesses the most considerate stability with the lowest formation energy of −9.033 eV compared to others. Band structures of systems are introduced to investigate a more excellent semiconductor capacity for Re-doped system with a band gap [Formula: see text] of 0.689 eV, with others having band gaps of 2.120, 2.159, 1.806, 1.837 and 0.879 eV, respectively, much smaller than that of pristine one, 3.113 eV. Moreover, absorption spectra curve reaches the lowest peak of [Formula: see text] for Os-doped system; simultaneously, the system exhibits a relatively negative reflectivity spectra and dielectric loss of 5.620 eV that are extensively expected in solar cell industry, predicting its broad scope of application prospects in photoelectric and microelectronic devices.
Interval Enclosures of Upper Bounds of Roundoff Errors Using Semidefinite Programming
Authors: Magron Victor 
Published: June 2018

A long-standing problem related to floating-point implementation of numerical programs is to provide efficient yet precise analysis of output errors.
We present a framework to compute lower bounds on largest absolute roundoff errors, for a particular rounding model. This method applies to numerical programs implementing polynomial functions with box constrained input variables. Our study is based on three different hierarchies, relying respectively on generalized eigenvalue problems, elementary computations, and semidefinite programming (SDP) relaxations. This is complementary of over-approximation frameworks, consisting of obtaining upper bounds on the largest absolute roundoff error. Combining the results of both frameworks allows one to get enclosures for upper bounds on roundoff errors.
The under-approximation framework provided by the third hierarchy is based on a new sequence of convergent robust SDP approximations for certain classes of polynomial optimization problems. Each problem in this hierarchy can be solved exactly via SDP. By using this hierarchy, one can provide a monotone nondecreasing sequence of lower bounds converging to the absolute roundoff error of a program implementing a polynomial function, applying for a particular rounding model.
We investigate the efficiency and precision of our method on nontrivial polynomial programs coming from space control, optimization, and computational biology.
Diagnostic Accuracy of a Machine-Learning Approach to Coronary Computed Tomographic Angiography–Based Fractional Flow Reserve
Authors: Coenen Adriaan , Kim Young-Hak , Kruk Mariusz , Tesche Christian , De Geer Jakob , Kurata Akira , Lubbers Marisa L. , Daemen Joost , Itu Lucian , Rapaka Saikiran , Sharma Puneet , Schwemmer Chris , Persson Anders , Schoepf U. Joseph , Kepka Cezary , Hyun Yang Dong , Nieman Koen 
Published: June 2018

Background:
Coronary computed tomographic angiography (CTA) is a reliable modality to detect coronary artery disease. However, CTA generally overestimates stenosis severity compared with invasive angiography, and angiographic stenosis does not necessarily imply hemodynamic relevance when fractional flow reserve (FFR) is used as reference. CTA-based FFR (CT-FFR), using computational fluid dynamics (CFD), improves the correlation with invasive FFR results but is computationally demanding. More recently, a new machine-learning (ML) CT-FFR algorithm has been developed based on a deep learning model, which can be performed on a regular workstation. In this large multicenter cohort, the diagnostic performance ML-based CT-FFR was compared with CTA and CFD-based CT-FFR for detection of functionally obstructive coronary artery disease.

Methods and Results:

At 5 centers in Europe, Asia, and the United States, 351 patients, including 525 vessels with invasive FFR comparison, were included. ML-based and CFD-based CT-FFR were performed on the CTA data, and diagnostic performance was evaluated using invasive FFR as reference. Correlation between ML-based and CFD-based CT-FFR was excellent (
R
=0.997). ML-based (area under curve, 0.84) and CFD-based CT-FFR (0.84) outperformed visual CTA (0.69;
P
<0.0001). On a per-vessel basis, diagnostic accuracy improved from 58% (95% confidence interval, 54%–63%) by CTA to 78% (75%–82%) by ML-based CT-FFR. The per-patient accuracy improved from 71% (66%–76%) by CTA to 85% (81%–89%) by adding ML-based CT-FFR as 62 of 85 (73%) false-positive CTA results could be correctly reclassified by adding ML-based CT-FFR.

Conclusions:
On-site CT-FFR based on ML improves the performance of CTA by correctly reclassifying hemodynamically nonsignificant stenosis and performs equally well as CFD-based CT-FFR.
Primary Myocardial Fibrosis as an Alternative Phenotype Pathway of Inherited Cardiac Structural Disorders
Authors: Junttila M. Juhani , Holmström Lauri , Pylkäs Katri , Mantere Tuomo , Kaikkonen Kari , Porvari Katja , Kortelainen Marja-Leena , Pakanen Lasse , Kerkelä Risto , Myerburg Robert J. , Huikuri Heikki V. 
Published: June 2018

Background:
Myocardial fibrosis is a common postmortem finding among young individuals with sudden cardiac death. Because there is no known single cause, we tested the hypothesis that some cases of myocardial fibrosis in the absence of identifiable causes (primary myocardial fibrosis [PMF]) are associated with genetic variants.

Methods:
Tissue was obtained at autopsy from 4031 consecutive individuals with sudden cardiac death in Northern Finland, among whom PMF was the only structural finding in 145 subjects with sudden cardiac death. We performed targeted next-generation sequencing using a panel of 174 genes associated with myocardial structure and ion channel function when autopsies did not identify a secondary basis for myocardial fibrosis. All variants with an effect on protein and with a minor allele frequency <0.01 were classified as pathogenic or variants of uncertain significance on the basis of American College of Medical Genetics consensus guidelines.

Results:
Among the 96 specimens with DNA passing quality control (66%), postmortem genetic tests identified 24 variants of known or uncertain significance in 26 subjects (27%). Ten were pathogenic/likely pathogenic variants in 10 subjects (10%), and 14 were variants of uncertain significance in 11 genes among 16 subjects (17%). Five variants were in genes associated with arrhythmogenic right ventricular cardiomyopathy, 6 in hypertrophic cardiomyopathy–associated genes, and 11 in dilated cardiomyopathy–associated genes; 2 were not associated with these disorders. Four unique variants of uncertain significance cosegregated among multiple unrelated subjects with PMF. No pathogenic/likely pathogenic variants were detected in ion channel–encoding genes.

Conclusions:
A large proportion of subjects with PMF at autopsy had variants in genes associated with arrhythmogenic right ventricular cardiomyopathy, dilated cardiomyopathy, and hypertrophic cardiomyopathy without autopsy findings of those diseases, suggesting that PMF can be an alternative phenotypic expression of structural disease–associated genetic variants or that risk-associated fibrosis was expressing before the primary disease. These findings have clinical implications for postmortem genetic testing and family risk profiling.
On the Pleromatic
Authors: Creighton Matthew 
Published: June 2018

Abstract
This essay meets at the crossroads of religion and literature, insofar as it concerns the extent to which fictional characters can articulate religious viewpoints. The subject here is D. H. Lawrence’s Women in Love with particular focus on the novel’s main character, Rupert Birkin. This essay argues that Birkin’s particular worldview, and the source of the strangeness with which it is encountered, is due to its location outside Judeo-Christian frameworks and inside a fundamentally “Gnostic” one. To prove this argument, I first adumbrate essential features of the Gnostic myth and then proceed to show how Birkin both reflects and departs from them.
Sexual Abuse in a Korean Evangelical Church in Japan
Authors: Sakurai Yoshihide 
Published: June 2018

Abstract
A case of sexual abuse by the supervisor of the Central Church of Holy God (Seishin Chūō Kyōkai 聖神中央教会) in 2005 has led many in the Japanese Christian community and the media to question the “cultification” of the Christian church. This paper will consider the incident and its background, one negative aspect of “church growth” in Japan, in which Korean evangelical and Pentecostal churches competed vigorously to attract devotees. The pastor who founded this church was a Korean resident in Japan who had studied theology and the propagation methodology in South Korea, allowing him to realize church growth in notoriously non-Christian Japan. Yet, his top-down authoritative management suppressed believers’ spiritual and physical freedom of religion. In the following case study, I consider how the asymmetrical relations among church members contributed to this religious abuse. After taking into account issues of missionary training, proselytization methodology, and social strata, I suggest that a dysfunction within the “comprehensive religious community” forces members’ total dependence on pastors in their belief as well as their lives.
Changes in Atmospheric Blocking Circulations Linked with Winter Arctic Warming: A New Perspective
Authors: Luo Dehai , Chen Xiaodan , Dai Aiguo , Simmonds Ian 
Published: June 2018

AbstractWinter atmospheric blocking circulations such as Ural blocking (UB) have been recognized to play an important role in recent winter Eurasian cooling. Observational analyses performed here reveal that the winter warming in the Barents–Kara Seas (BKS) related to the recent decline of sea ice concentration (SIC) has been accompanied by a large increase in the mean duration of the UB events. A new energy dispersion index (EDI) is designed to help reveal the physics behind this association and show how the BKS warming can influence the mean duration of UB events. This EDI mainly reflects the role of the meridional potential vorticity (PV) gradient in the blocking persistence and it characterizes the changes in energy dispersion and nonlinearity strength of blocking. The meridional PV gradient combines the relative vorticity gradient (related to the nonuniform meridional shear of the mean zonal wind) and the mean zonal wind strength. It is revealed that the BKS warming leads to a significant lengthening of the UB duration because of weakened energy dispersion and intensified nonlinearity of the UB through reduced meridional PV gradient. Furthermore, the duration of the UB is found to depend more strongly on the meridional PV gradient than the mean westerly wind strength, although the meridional PV gradient includes the effect of mean westerly wind strength. Thus, the meridional PV gradient is a better indicator of the change in the blocking duration related to Arctic warming than the zonal wind strength index.
Transient Hyperthyroidism Induced by Thyroid Ultrasound
Authors: Yatavelli Rajini K. , Levine Steven N. 
Published: June 2018

Objectives: Transient hyperthyroidism has been documented following surgical manipulation or direct trauma to the normal thyroid gland. This has best been studied in patients following parathyroidectomy and also reported following trauma to the neck, strangulation, and vigorous palpation of the thyroid gland. It has not previously been reported following a thyroid ultrasound. Methods: We report the case of a 58-year-old euthyroid woman with a large nontoxic multinodular goiter who developed transient hyperthyroidism following an ultrasound of the thyroid gland. She was not treated with anti-thyroid medications. Results: Two weeks later, her free T3 and free T4 were normal, and 11 weeks after the ultrasound, all thyroid tests, including her TSH, were within the reference range. Conclusions: We believe this is the first report of a euthyroid individual who developed hyperthyroidism caused by thyroid ultrasonography. We hypothesize that pressure from the ultrasound probe during the examination compressed her large nodules, releasing stored hormone.
His and Her Retirement: Effects of Gender and Familial Caregiving Profiles on Retirement Timing
Authors: Stoiko Rachel R. , Strough JoNell 
Published: June 2018

Objectives Retirement timing has been linked to a host of outcomes for individuals, families, and societies. The present study predicted retirement timing using profiles of preretirement family caregiving and gender. Method Using longitudinal data from the Health and Retirement Study, cluster analysis was used to create profiles of preretirement family caregiving (operationalized as time and financial transfers to aging parents and adult children). These profiles, as well as gender, were used to predict later retirement timing. Results Four distinct preretirement caregiving profiles were evident. All profiles retired, on average, earlier than their full eligibility for Social Security benefits. A main effect of caregiving profile, but not gender, was evident. The Eldercare profile, which was characterized by high levels of time and financial transfers to aging parents, retired the earliest. There was not a significant interaction between caregiving profile and gender. Discussion When men enacted female-typical caregiving roles, their retirement timing resembled women’s. Eldercare, in particular, was associated with earlier retirement timing. Implications for individual retirement decision-making and policy are discussed.
Impure but not inactive: Behavioral pharmacology of dibenzylpiperazine, a common by-product of benzylpiperazine synthesis
Authors: Dolan Sean B , Shetty Ritu A , Forster Michael J , Gatch Michael B 
Published: June 2018

Background: Substituted piperazines comprise a substantial proportion of the novel psychoactive substance market. Among the most widely abused piperazine compounds are meta-chlorophenylpiperazine (mCPP), tri-fluoromethylphenylpiperazine (TFMPP), and, especially, benzylpiperazine (BZP), which are commonly incorporated, either alone or in combination, in illicit “party pills” or “ecstasy” formulations. Illicit synthesis of BZP often results in production of an impure by-product dibenzylpiperazine (DBZP), which frequently appears alongside BZP in these formulations; however, despite its ubiquity, little information exists regarding the abuse liability of DBZP. Aims: The current study aimed to evaluate the abuse-related behavioral pharmacology of DBZP. Methods: DBZP, mCPP, and TFMPP were tested in parallel in mice in locomotor activity and conditioned place preference assays, and in a drug discrimination assay with rats trained to discriminate either methamphetamine, cocaine, (±)-3,4-methylenedioxymethamphetamine (MDMA), or -2,5-dimethoxy-4-methylamphetamine(DOM). Results: Each of the compounds tested produced dose-dependent decreases in locomotor activity. DBZP substituted fully for methamphetamine, produced subthreshold drug-appropriate responding for cocaine and MDMA, and failed to substitute for DOM. Conversely, TFMPP and mCPP only produced subthreshold drug-appropriate responding for methamphetamine and MDMA, respectively, and both compounds failed to substitute for cocaine or DOM. None of the compounds tested produced a place preference. DBZP produced convulsions in rats at the highest dose tested. Conclusions: These data indicate that DBZP is more similar to BZP, albeit with lower potency and efficacy, than its serotonergic piperazine counterparts, and is a behaviorally-active compound with some abuse liability and potential for adverse health effects.
Methicillin-resistant Staphylococcus aureus nasal colonization and infection in an intensive care unit of a university hospital in China
Authors: Qiao Fu , Huang Wenzhi , Cai Lin , Zong Zhiyong , Yin Weijia 
Published: June 2018

Objective This study was performed to determine the prevalence and risk factors associated with nasal methicillin-resistant Staphylococcus aureus (MRSA) colonization upon intensive care unit (ICU) admission and during the ICU stay in mainland China. Methods A prospective observational study was performed in a 50-bed general ICU of a 4300-bed teaching hospital in China from 2011 to 2013. Nasal swabs for MRSA detection were obtained upon ICU admission and at discharge for patients having stayed in the ICU for longer than 3 days. Results In total, 115 patients (4.1%; 95% confidence interval [CI], 3.4–4.9) were already colonized with MRSA on ICU admission, and another 185 patients (10.7%; 95% CI, 9.3–12.2) acquired MRSA during their ICU stay. Development of an MRSA infection was significantly more likely in patients with than without MRSA colonization on ICU admission (odds ratio [OR], 2.8; 95% CI, 1.1–7.3). Patients who acquired MRSA had significantly prolonged lengths of stay in the ICU (23.3 days) and higher hospital bills (135,171 RMB; about 19,590 USD) than those who tested negative for MRSA. Conclusion The MRSA colonization rate among ICU patients in mainland China is high. Patients with MRSA-positive nasal swabs are more likely to develop MRSA infections.