bluuebunny/crossref_metadata_2025_split huggingface dataset:
Complications following 250 cemented modular hip hemiarthroplasties
Authors: Ekman E. , Nurmi H. , Reito A. , Paloneva J. 
Published: November 2018

Background and Aims: Hemiarthroplasty is a common method of treating displaced femoral neck fractures, especially among elderly non-active patients with frailty syndrome. Complications arising from the use of a modern, modular hemiendoprosthesis via a posterior approach have been poorly reported in this population. The aim of this study was to evaluate complications and mortality associated with the use of Lubinus sp II cemented, unipolar hemiarthroplasty prosthesis and posterior approach during a 9-year follow-up. Material and Methods: All patients (244) who received hemiarthroplasty due to an acute fracture of the femoral neck in Central Finland Hospital, Jyvaskyla, Finland, during 2007 and 2008 were included. Patient records were retrospectively reviewed for intraoperative and postoperative complications. Results and Conclusion: Women composed 70% (n = 171) of the study population. Mean age was 83 years for women and 80 years for men. A total of 31 (12%) complications were found in 30 patients. These were 12 dislocations (5% of all patients), 5 (2%) periprosthetic fractures, 2 (0.8%) superficial and 5 (2%) deep infections, 1 (0.4%) protrusion of the prosthesis, 2 (0.8%) intraoperative fractures, and 2 (0.8%) partial sciatic nerve palsies. Conversion to total hip replacement was performed in 9 cases (4%) and a reoperation was required in 15 (6%) cases. Mortality rate at 9 years was 78% (95% confidence interval = 72%–83%). The overall rate of complications was acceptable although mortality was high in this comorbid patient population. The need for conversion to total hip arthroplasty and reoperation is low.
Factors Affecting Inferior Vena Cava Filter Retrieval: A Review
Authors: Crumley Kristen D. , Hyatt Eddie , Kalva Sanjeeva P. , Shah Hriday 
Published: November 2018

Objective: Over the last 2 decades, there has been an exponential rise in placement of retrievable inferior vena cava (IVC) filters, while the retrieval rate has remained steadily low. Approaches to increasing filter retrieval rates have been extensively studied. Conclusion: This review presents an up-to-date review of reported data-driven variables that affect retrieval rates of IVC filters, with a focus on clinical, technical, and process factors.
Conservative management and radical treatment in localised prostate cancer: A systematic review with meta-analysis and trial sequential analysis
Authors: Ng Ka Ting , Kwok Pei En , Teoh Wan Yi 
Published: November 2018

Background: Several randomised control trials comparing conservative management (watchful waiting/observation/active monitoring) and radical treatments (radical prostatectomy/radiotherapy) for localised prostate cancer with at least more than 10 years of follow-up (median) have been published with conflicting findings. The primary aim of this study was to determine all-cause mortality and prostate cancer-related mortality between conservative management and radical treatment for localised prostate cancer. Methods: All randomised clinical trials were searched in MEDLINE, EMBASE, PubMed and CENTRAL from their inception until September 2018. Results: Four trials were eligible ( n = 3211) for inclusion in the data synthesis. In patients who had radical treatment, the incidence of all-cause mortality and prostate cancer-related mortality (three trials, 3069 patients) were reduced (with odds ratio, i.e. 95% confidence interval (CI)), of 1.37 (1.14–1.64), ρ < 0.001, low quality of evidence and odd ratio (95% CI) of 1.74 (1.31–2.30), ρ < 0.001, low quality of evidence, respectively). The radical treatment group was associated with reduced incidence of distant metastases, the odds ratio (95% CI) being 1.87 (1.48–2.36), ρ < 0.001, low quality of evidence. However, patients who were randomised to radical treatment had a significantly higher incidence of erectile dysfunction (the odds ratio (95% CI) being 0.62 (0.39–0.98), ρ = 0.04, very low quality of evidence) and urinary incontinence (odds ratio (95% CI) of 0.42 (0.21–0.86), ρ = 0.02, very low quality of evidence). Conclusions: In summary, radical treatments reduce all-cause mortality, and prostate cancer-related and distant metastases, at the expense of higher incidence of erectile dysfunction and urinary incontinence. The general quality of evidence ranged from very low to low. Level of evidence: 1a PROSPERO Registration Number: CRD42017072687
Poor Performance on Single-Legged Hop Tests Associated With Development of Posttraumatic Knee Osteoarthritis After Anterior Cruciate Ligament Injury
Authors: Wellsandt Elizabeth , Axe Michael J. , Snyder-Mackler Lynn 
Published: November 2018

Background: The risk for knee osteoarthritis (OA) is substantially increased after anterior cruciate ligament (ACL) injury. Tools are needed to identify characteristics of patients after ACL injury who are most at risk for posttraumatic OA. Purpose: To determine whether clinical measures of knee function after ACL injury are associated with the development of radiographic knee OA 5 years after injury. Study Design: Cohort study; Level of evidence, 2. Methods: A total of 76 athletes (mean age, 28.7 ± 11.3 years; 35.5% female) with ACL injury were included. Clinical measures of knee function (quadriceps strength, single-legged hop tests, patient-reported outcomes) were assessed after initial impairment resolution (baseline), after 10 additional preoperative or nonoperative rehabilitation sessions (posttraining), and 6 months after ACL reconstruction or nonoperative rehabilitation. Posterior-anterior bent-knee radiographs were completed at 5 years and graded in the medial compartment by use of the Kellgren-Lawrence system. Logistic regression models were used at each of the 3 time points to determine the ability of clinical measures to predict knee OA at 5 years. Results: Of the 76 patients, 9 (11.8%) had knee OA at 5 years. After adjustment for ACL reconstruction compared with nonoperative management, ipsilateral second ACL injuries, and the presence of contralateral knee OA, clinical measures of knee function at posttraining (6-m timed hop, Knee Outcomes Survey–Activities of Daily Living Scale) explained the most variance in posttraumatic OA development at 5 years ( P = .006; ▵ R2, 27.5%). The 6-m hop test was the only significant posttraining predictor of OA at 5 years ( P = .023; patients without OA, 96.6% ± 5.4%; patients with OA, 84.9% ± 14.1%). Similar significant group differences in hop scores and subjective knee function were present at baseline. No significant group differences in clinical measures existed at 6 months after ACL reconstruction or nonoperative rehabilitation. Conclusion: Poor performance in single-legged hop tests early after ACL injury but not after reconstruction or nonoperative rehabilitation is associated with the development of radiographic posttraumatic knee OA 5 years after injury. Clinical measures of knee function were most predictive of subsequent OA development following an extended period of rehabilitation early after ACL injury.
RETRACTED ARTICLE: MNAT1 is overexpressed in colorectal cancer and mediates p53 ubiquitin-degradation to promote colorectal cancer malignance
Authors: Zhou Shan , Lu Jinping , Li Yuejin , Chen Chan , Cai Yongqiang , Tan Gongjun , Peng Zhengke , Zhang Zhenlin , Dong Zigang , Kang Tiebang , Tang Faqing 
Published: November 2018

Abstract
Background
MNAT1 (menage a trois 1, MAT1), a cyclin-dependent kinase-activating kinase (CAK) complex, high expresses in various cancers and is involved in cancer pathogenesis. However, mechanisms underlying its regulation in carcinogenesis are unclear.

Methods
The tissue microarray of colorectal cancer (CRC) was used to evaluate MNAT1 expressions in CRC tissues using immunohistochemistry, CRC cell lines were also detected MNAT1 expression using Western-blotting. MNAT1 and shMNAT1 vectors were constructed, and transfected into CRC cells. Cell growths of the transfected cells were observed using MTT and colony formation. The affects of MNAT1 on p53 expression were analyzed using Western-blotting and Real-time PCR. Immunoprecipitation assay was used to analyze the interaction p53 and MNAT1, and Western-blotting was used to test the effects of MNAT1 on p53 downstream molecules. The apoptosis of CRC cells with MNAT1 or shMNAT1 were analyzed using flow cytometry. BABL/c athymic nude mice were used to observe the effect of MNAT1 on CRC cell growth in vivo.

Results
MNAT1 was found to be overexpressed in CRC tissues and cells, and MNAT1 expressions in CRC tissue samples were associated with CRC carcinogenesis and poor patient outcomes. MNAT1-knockin increased CRC cell growth and colony formation, and MNAT1-knockdown dramatically decreased cell motility and invasion. MNAT1 physically interacted with p53, MNAT1 also increased the interaction of MDM2 with p53. Strikingly, MNAT1 mediated p53 ubiquitin-degradation. MNAT1 shortened p53 half-life, and ectopic MNAT1 expression decreased p53 protein stability. Moreover, MNAT1 induced RAD51 and reduced p21, cleaved-caspase3, cleaved-PARP and BAX expression. MNAT1 inhibited CRC cell apoptosis. shMANT1 decreased tumor growths in nude mice following p53 increase.

Conclusion
MNAT1 binds to p53, mediates p53 ubiquitin-degradation through MDM2, increases cell growth and decreases cell apoptosis, and finally promotes CRC malignance. MNAT1 binding to p53 and mediating p53 ubiquitin-degradation axis represents a novel molecular joint in the p53 pathway.
A tissue communication network coordinating innate immune response during muscle stress
Authors: Green Nicole , Walker Justin , Bontrager Alexandria , Zych Molly , Geisbrecht Erika R. 
Published: November 2018

ABSTRACT
Complex tissue communication networks function throughout an organism's lifespan to maintain tissue homeostasis. Using the genetic model Drosophila melanogaster, we have defined a network of immune responses that are activated following the induction of muscle stresses, including hypercontraction, detachment and oxidative stress. Of these stressors, loss of the genes that cause muscle detachment produced the strongest levels of JAK-STAT activation. In one of these mutants, fondue (fon), we also observe hemocyte recruitment and the accumulation of melanin at muscle attachment sites (MASs), indicating a broad involvement of innate immune responses upon muscle detachment. Loss of fon results in pathogen-independent Toll signaling in the fat body and increased expression of the Toll-dependent antimicrobial peptide Drosomycin. Interestingly, genetic interactions between fon and various Toll pathway components enhance muscle detachment. Finally, we show that JAK-STAT and Toll signaling are capable of reciprocal activation in larval tissues. We propose a model of tissue communication for the integration of immune responses at the local and systemic level in response to altered muscle physiology.
Ancestralidade negro-brasileira no romance Ponciá Vicêncio, de Conceição Evaristo
Authors: Freitas Ricardo Oliveria de , Santos Sandra Andrade dos 
Published: November 2018

Investigamos o modo com que a ancestralidade negro-brasileira vai se apresentar como elemento constitutivo na narrativa de Conceição Evaristo, através da análise do romance de sua autoria, Ponciá Vicêncio (2003). Reconhecendo a densidade literária da autora, exploramos a construção da personagem Ponciá Vicêncio, apresentando elementos identificadores do que defendemos como sendo um conjunto de traços de ancestralidade presentes na obra. Relacionamos esses elementos às categorias de memória e silêncio. Apoiados no romance Ponciá Vicêncio, analisamos os modos e formas com que Conceição Evaristo, através do artifício da escrevivência (a escrita do cotidiano, da memória da sua vida e do seu povo). Com isso, revelamos a experiência de ser mulher negra numa sociedade pós-abolicionista, que, sem abrir mão do caráter poético, utiliza como dispositivos aspectos da ancestralidade negro-brasileira com grande aporte da memória, de uma memória ancestral negro-brasileira.
Impact of adipose tissue on prostate cancer aggressiveness – analysis of a high-risk population
Authors: Delouya Guila , Tiberi David , Bhatnagar Sahir R. , Campeau Shanie , Saad Fred , Taussky Daniel 
Published: November 2018

Abstract

Background
We investigated whether visceral adiposity is associated with more aggressive disease at prostatectomy.

Materials and methods
Four hundred and seventy-four patients referred for postoperative adjuvant or salvage radiotherapy were included in this study. Primary endpoints were positive surgical margins (pSM) or extracapsular extension (ECE). Visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) were manually contoured. Univariate and multivariate logistic regression was performed.

Results
In univariate analysis, VAT volume (p = 0.006), adipose tissue ratio (VAT/SAT, p = 0.003), density of the SAT (p = 0.04), as well as age (p < 0.001) were associated with pSM. In the univariate analysis, SAT density was associated with a trend towards a higher rate of ECE (p = 0.051) but visceral fat volume (p = 0.01), as well as the adipose tissue ratio (p = 0.03) were both protective factors. None of the adipose tissue measurements or BMI had an influence on biochemical recurrence or overall survival (all p ≥ 0.5).

Conclusions
SAT-volume and increased SAT-density were generally associated with more aggressive prostate cancers whereas VAT as a protective factor. These findings emphasize a possible mechanism for the association between obesity and prostate cancer aggressiveness.
Evaluating RSOA Performance with Optical Logic Gates at 100 Gbps Data Rate
Authors: Tripathi Devendra Kr. 
Published: November 2018

Abstract
All optical logic gates are the key elements of contemporary optical computing unit. For that non-linear attribute of reflective semiconductor optical amplifier (RSOA) is exploited to configure optical logic gates. Accordingly, in the manuscript all optical OR/NOR/Buffer binary logic network for the nonreturn to zero format has been designed. Its operation at 100 Gbps data rate has been successfully realized. For the applied data inputs in nonreturn to zero patterns, their corresponding output waveforms for the stated logic action have been verified. Numerical investigations for the imperative design constraints as data rate, injected power and imperative elements of the semiconductor optical amplifiers (SOAs) pump current, carrier density, active length, confine factor, laser power has been appropriately executed with optimum performance. It has depicted good extinction ratio (>10 dB) performance with confine factor more than 0.2 and higher carrier density of amplifier. Further, it also accomplished, that for the OR, buffer logic execution with lower power of pump laser and for the NOR logic execution higher power laser pump source is required. The proposed design could fulfill need for the impending higher data rate composite optical computing units.
The Priestly Slave Revolt in Morality
Authors: Loeb Paul S. 
Published: November 2018

Abstract
In this essay I evaluate a new and influential interpretation of Nietzsche’s idea of the slave revolt in morality. This interpretation was first proposed by Bernard Reginster and has since been extended by R. Lanier Anderson and Avery Snelson. Citing textual evidence from Beyond Good and Evil and On the Genealogy of Morality, these scholars have argued for the counterintuitive view that nobles, not slaves, instigated the slave revolt in morality. This is because Nietzsche says that nobles create new values, introduces priests as nobles, and claims that priests began the slave revolt. However, against this new approach I argue that these scholars neglect important evidence from these same texts in which Nietzsche claims that the psychologically slavish can also create values, assumes that politically subordinated nobles can lose their psychological nobility, and asserts that the slave revolt was instigated by psychologically slavish priests. I also argue that these scholars ignore Nietzsche’s related claims that the priestly peasant Luther renewed the Jewish slave revolt against re-ascendant Roman nobles and that the plebeian philosopher Socrates led a slave revolt in morality against the Athenian nobles. Thus, it turns out that none of the leaders of the slave revolt were noble and that one of them was not even priestly. I conclude with a defense of the traditional and straightforward view that Nietzsche always conceived of the slave revolt in morality as an act of revenge by oppressed people who are politically and psychologically ignoble.
Representationalism in Nietzsche’s Early Physics: Cosmology and Sensation in the Zeitatomenlehre
Authors: Rayman Joshua 
Published: November 2018

Abstract
Nietzsche’s 1873 fragment, the Zeitatomenlehre, posits a temporal conception of action at a distance where space is reduced to a single point and time consists only in a series of discrete atoms. Taken as a physical doctrine that destroys all spatial difference, this conception raises serious conflicts with the rest of his work. I describe and situate this theory within the historical context of debates over action at a distance in nineteenth-century physics, distinguish it from physical theories influential on Nietzsche, and argue that these conflicts can be resolved only by viewing it in the anti-metaphysical phenomenalist and representational terms that he also expressed in his early work.
Eugen Dühring: Ein handschriftliches „Nietzsche“-Stichwort von 1896
Authors: Rauh Hans-Christoph 
Published: November 2018

Abstract
Eugen Dühring - A handwritten note on ‘Nietzsche’ from 1896. This paper contains the first publication of a yet unknown manuscript, which Eugen Dühring wrote in response to his reading of - in part falsified and decontextualized - passages about him in Koegel’s edition of Nietzsche’s late notes. Dühring’s note reveals blatant anti-Semitism and he vituperates Nietzsche as a ‘lawyer’ of Jews. The note is subsequently used in later publications of Dühring and his followers. The paper continues to reconstruct Dühring’s engagement with Nietzsche and discusses some aspects of Nietzsche’s reading of Dühring. Despite Dühring’s significance for Nietzsche’s philosophical development, initial similarities are outweighed by important differences.
Complexity and Ambivalence in Nietzsche’s Relationship with Wagner
Authors: Holub Robert C. 
Published: November 2018

Abstract
This review essay expands on two excellent collections dealing with Nietzsche and Wagner and is drawn from the proceedings of conferences in the bicentennial year of Wagner’s birth. It points to four areas underplayed in the contributions. The first involves Nietzsche’s adoption of Wagnerian ideology, especially anti-Judaism, in the late 1860s and early 1870s. The second deals with Nietzsche’s actual activities and sentiments regarding the inaugural Bayreuth festival in 1876 and his later reports of these activities and sentiments. A third topic concerns the break from Wagner, its likely causes, and its stylization in Nietzsche’s recollections from the 1880s. And lastly the essay examines the ambivalence toward Wagner in Nietzsche’s writings from 1888 as part of an autobiographical imperative. In general, the collections reviewed place too much trust in Nietzsche’s own accounts of the relationship with Wagner and fail to recognize that, especially in the 1880s, the philosopher is engaged in a process of self-fashioning to bring his current views into harmony with a history embellished and manipulated to give the appearance of linear development and consistent beliefs.
Prinzipien der Sprachwahl im Tourismus, mit Schwerpunkt auf sprachlicher Höflichkeit
Authors: Ammon Ulrich 
Published: November 2018

Abstract
After defining the concept of ‚tourist‘ and distinguishing ‚inbound tourists‘ from ‚outbound tourists‘, the article focuses on questions of politeness towards tourists who are seen and treated as customers of their goals’ tourist industry. One possibility of treating them politely is the adequate language choice with respect to their mother tongue, I which they will, as a rule expect to be addressed, if it is a language of considerable international standing (e.g. French or German) or spoken by many tourists in the respective location. Otherwise they will consider it at least more polite to be addressed in a lingua franca, mostly English, than in the local language of the tourist destination. Tourist will find it particularly polite to be addressed in their own mother language if it does not rank among the more international languages. These hypotheses are deduced from well-founded politeness theories based on face-saving and identity assumptions and are illustrated by examples in order to show ways of further empirical corroboration or falsification.
Nine Post-Hexaplaric Readings in the Arabic Translation of the Book of Numbers by al-Ḥārith b. Sinān b. Sunbāṭ (10th c. CE)
Authors: Monferrer-Sala Juan Pedro 
Published: November 2018

Zusammenfassung
MSS Laud. Or. 243 (= A2) und Laud. Or. 248 (= A3) bewahren neun nach-hexaplarische (A3 nur zwei) Lesungen der arabischen Version des Numeribuches, das von al-Ḥārith b. Sinān b. Sunbāṭ (10. Jhd. n. Chr.) nach der Syro-Hexapla Version von Paul von Tellā übersetzt wurde. Diese neun nach-hexaplarischen Lesungen, die mit den Aristarchianischen Symbolen markiert sind, werden mit der Erwartung untersucht, dass sie neues Licht auf die Entwicklung der nach-hexaplarischen Studien in der syrisch-arabischen Periode werfen werden. Zugleich werden Informationen zu den Techniken und Strategien, die der arabische Übersetzer einsetzte, zur Verfügung gestellt, um die Edition bislang unpublizierter hexaplarischer arabischer Texte zu befördern.
Overweight Mice Show Coordinated Homeostatic and Hedonic Transcriptional Response across Brain
Authors: De Toma I. , Grabowicz I. E. , Fructuoso M. , Trujillano D. , Wilczyński B. , Dierssen M. 
Published: November 2018

AbstractObesogenic diets lead to overeating and obesity by inducing the expression of genes involved in hedonic and homeostatic responses in specific brain regions. However, how the effects on gene expression are coordinated in the brain so far remains largely unknown. In our study, we provided mice with access to energy-dense diet, which induced overeating and overweight, and we explored the transcriptome changes across the main regions involved in feeding and energy balance: hypothalamus, frontal cortex, and striatum. Interestingly, we detected two regulatory processes: a switch-like regulation with differentially expressed (DE) genes changing over 1.5-fold and “fine-tuned” subtler changes of genes whose levels correlated with body weight and behavioral changes. We found that genes in both categories were positioned within specific topologically associated domains (TADs), which were often differently regulated across different brain regions. These TADs were enriched in genes relevant for the physiological and behavioral observed changes. Our results suggest that chromatin structure coordinates diet-dependent transcriptional regulation.