bluuebunny/crossref_metadata_2025_split huggingface dataset:
A wind‐tunnel study of the wake development behind wind turbines over sinusoidal hills
Authors: Hyvärinen Ann , Lacagnina Giovanni , Segalini Antonio 
Published: March 2018

AbstractIn the present work, the wake development behind small‐scale wind turbines is studied when introducing local topography variations consisting of a series of sinusoidal hills. Additionally, wind‐tunnel tests with homogeneous and sheared turbulent inflows were performed to understand how shear and ambient turbulence influence the results. The scale of the wind‐turbine models was about 1000 times smaller than full‐size turbines, suggesting that the present results should only be qualitatively extrapolated to real‐field scenarios. Wind‐tunnel measurements were made by means of stereoscopic particle image velocimetry to characterize the flow velocity in planes perpendicular to the flow direction. Over flat terrain, the wind‐turbine wake was seen to slowly approach the ground while it propagated downstream. When introducing hilly terrain, the downward wake deflection was enhanced in response to flow variations induced by the hills, and the turbulent kinetic energy content in the wake increased because of the speed‐up seen over the hills. The combined wake observed behind 2 streamwise aligned turbines was more diffused and when introducing hills, it was more prone to deflect towards the ground compared to the wake behind an isolated turbine. Since wake interactions are common at sites with multiple turbines, this suggested that it is important to consider the local hill‐induced velocity variations when onshore wind farms are analysed. Differences in the flow fields were seen when introducing either homogeneous or sheared turbulent inflow conditions, emphasizing the importance of accounting for the prevailing turbulence conditions at a given wind‐farm site to accurately capture the downstream wake development.
Sound propagation through the wake flow of a hilltop wind turbine—A numerical study
Authors: Heimann Dietrich , Englberger Antonia , Schady Arthur 
Published: March 2018

AbstractThe sound propagation from a wind turbine situated on the top of a hill into the downwind domain is studied by numerical simulations for 13 cases with varying hill geometry and inflow conditions. The influence of the hill on the atmospheric flow and the wake due to the rotor are simulated by precursory large‐eddy simulations. In addition to the combined consideration of hill and turbine wake effects, these effects are also separately evaluated. The results show that placing the turbine on top of a hill leads to slightly lower sound levels on the downwind plane, although the wake alone supports downward refraction and tends to increase the sound impact near the ground at greater distance. Variations of the hill geometry and the inflow conditions do not have significant effects on the near‐ground sound levels in the downwind domain.
Rapid and stable production of 2,3-butanediol by an engineered Saccharomyces cerevisiae strain in a continuous airlift bioreactor
Authors: Yamada Ryosuke , Nishikawa Riru , Wakita Kazuki , Ogino Hiroyasu 
Published: March 2018

Abstract
Utilization of renewable feedstocks for the production of bio-based bulk chemicals, such as 2,3-butanediol (2,3-BDO), by engineered strains of the non-pathogenic yeast, Saccharomyces cerevisiae, has recently become an attractive option. In this study, to realize rapid production of 2,3-BDO, a flocculent, 2,3-BDO-producing S. cerevisiae strain YPH499/dPdAdG/BDN6-10/FLO1 was constructed from a previously developed 2,3-BDO-producing strain. Continuous 2,3-BDO fermentation was carried out by the flocculent strain in an airlift bioreactor. The strain consumed more than 90 g/L of glucose, which corresponded to 90% of the input, and stably produced more than 30 g/L of 2,3-BDO over 380 h. The maximum 2,3-BDO productivity was 7.64 g/L/h at a dilution rate of 0.200/h, which was higher than the values achieved by continuous fermentation using pathogenic bacteria in the previous reports. These results demonstrate that continuous 2,3-BDO fermentation with flocculent 2,3-BDO-producing S. cerevisiae is a promising strategy for practical 2,3-BDO production.
Correction to: Nickel hyperaccumulation in Antidesma montis‐silam: from herbarium discovery to collection in the native habitat
Authors: Nkrumah Philip Nti , Echevarria Guillaume , Erskine Peter Damian , van der Ent Antony 
Published: March 2018

AbstractThe article “Nickel hyperaccumulation in Antidesma montis‐silam: from herbarium discovery to collection in the native habitat”, written by Philip Nti Nkrumah, Guillaume Echevarria, Peter Damian Erskine, Antony van der Ent, was originally published electronically on the publisher's internet portal (currently SpringerLink) on 08 December 2017 without open access.
Can neuropsychological testing facilitate differential diagnosis between at-risk mental state (ARMS) for psychosis and adult attention-deficit/hyperactivity disorder (ADHD)?
Authors: Studerus Erich , Corbisiero Salvatore , Mazzariello Nadine , Ittig Sarah , Leanza Letizia , Egloff Laura , Beck Katharina , Heitz Ulrike , Andreou Christina , Stieglitz Rolf-Dieter , Riecher-Rössler Anita 
Published: March 2018

AbstractBackground:Patients with an at-risk mental state (ARMS) for psychosis and patients with attention-deficit/hyperactivity disorder (ADHD) have many overlapping signs and symptoms and hence can be difficult to differentiate clinically. The aim of this study was to investigate whether the differential diagnosis between ARMS and adult ADHD could be improved by neuropsychological testing.Methods:168 ARMS patients, 123 adult ADHD patients and 109 healthy controls (HC) were recruited via specialized clinics of the University of Basel Psychiatric Hospital. Sustained attention and impulsivity were tested with the Continuous Performance Test, verbal learning and memory with the California Verbal Learning Test, and problem solving abilities with the Tower of Hanoi Task. Group differences in neuropsychological performance were analyzed using generalized linear models. Furthermore, to investigate whether adult ADHD and ARMS can be correctly classified based on the pattern of cognitive deficits, machine learning (i.e. random forests) was applied.Results:Compared to HC, both patient groups showed deficits in attention and impulsivity and verbal learning and memory. However, in adult ADHD patients the deficits were comparatively larger. Accordingly, a machine learning model predicted group membership based on the individual neurocognitive performance profile with good accuracy (AUC = 0.82).Conclusions:Our results are in line with current meta-analyses reporting that impairments in the domains of attention and verbal learning are of medium effect size in adult ADHD and of small effect size in ARMS patients and suggest that measures of these domains can be exploited to improve the differential diagnosis between adult ADHD and ARMS patients.
Influence of prostate size on the perioperative and postoperative outcome of transurethral plasmakinetic enucleation of the prostate: Results of 892 patients with 3 years of follow‐up
Authors: Chen Shu‐Shang , Lin Mei‐Jiao , Weng Ming‐Fang , Zhu Ling‐Feng , Deng Zhen , Wu Cheng‐Yao , Cai Jin‐Quan , Wu Wei‐Zhen , Tan Jian‐Ming 
Published: March 2018

AbstractTo explore the influence of prostate size on the outcome of Plasmakinetic enucleation of the prostate (PkEP) for the treatment of benign prostate hyperplasia (BPH), The data of 892 patients with symptomatic BPH who underwent PkEP were retrospectively reviewed. Among them, 199 (22.31%) had the prostate size smaller than 40 g (Group 1), 409 (45.85%) between 40 and 79 g (Group 2), 197 (22.09%) between 80 and 120 g (Group 3), and 87 (9.75%) larger than 120 g (Group 4). Perioperative variables, perioperative and postoperative complications were recorded. Patients were followed up for 36 months postoperatively. The efficiency of the surgery increased as the prostate size increased. Greater decreases in hemoglobin were noted in groups with larger prostates, while the duration of catheterization after the operation was similar across all groups. During the 3‐year follow‐up, the postoperative improvement in International Prostate Symptom Score (IPSS), Quality of Life (QOL), maximal flow rate (Qmax) and post‐void residual urine volume (PVR), as well as longterm complications including urethral stricture and bladder‐neck contracture were comparable across the 4 groups. These findings revealed that PkEP is more efficient for large prostate and can treat all prostates regardless of the size with equivalent symptom relief and micturition improvement.
Challenging aspects of contemporary cochlear implant electrode array design
Authors: Mistrík Pavel , Jolly Claude , Sieber Daniel , Hochmair Ingeborg 
Published: March 2018

ObjectiveA design comparison of current perimodiolar and lateral wall electrode arrays of the cochlear implant (CI) is provided. The focus is on functional features such as acoustic frequency coverage and tonotopic mapping, battery consumption and dynamic range. A traumacity of their insertion is also evaluated.MethodsReview of up‐to‐date literature.ResultsPerimodiolar electrode arrays are positioned in the basal turn of the cochlea near the modiolus. They are designed to initiate the action potential in the proximity to the neural soma located in spiral ganglion. On the other hand, lateral wall electrode arrays can be inserted deeper inside the cochlea, as they are located along the lateral wall and such insertion trajectory is less traumatic. This class of arrays targets primarily surviving neural peripheral processes. Due to their larger insertion depth, lateral wall arrays can deliver lower acoustic frequencies in manner better corresponding to cochlear tonotopicity. In fact, spiral ganglion sections containing auditory nerve fibres tuned to low acoustic frequencies are located deeper than 1 and half turn inside the cochlea. For this reason, a significant frequency mismatch might be occurring for apical electrodes in perimodiolar arrays, detrimental to speech perception. Tonal languages such as Mandarin might be therefore better treated with lateral wall arrays. On the other hand, closer proximity to target tissue results in lower psychophysical threshold levels for perimodiolar arrays. However, the maximal comfort level is also lower, paradoxically resulting in narrower dynamic range than that of lateral wall arrays. Battery consumption is comparable for both types of arrays.ConclusionsLateral wall arrays are less likely to cause trauma to cochlear structures. As the current trend in cochlear implantation is the maximal protection of residual acoustic hearing, the lateral wall arrays seem more suitable for hearing preservation CI surgeries. Future development could focus on combining the advantages of both types: perimodiolar location in the basal turn extended to lateral wall location for higher turn locations.
Identification of activity peaks in time-tagged data with a scan-statistics driven clustering method and its application to gamma-ray data samples
Authors: Pacciani Luigi 
Published: March 2018

Context.The investigation of activity periods in time-tagged data samples is a topic of great interest. Among astrophysical samples, gamma-ray sources are widely studied, due to the huge quasi-continuum data set available today fromFermi-LAT (FermiLarge Area Telescope) and the AGILE-GRID (Astro Rivelatore Gamma a Immagini LEggero-Gamma Ray Imaging Detector)Aims.To reveal flaring episodes of a given gamma-ray source, researchers make use of binned light curves. This method suffers from several drawbacks: the results depend on time-binning and the identification of activity periods is difficult for bins with a low signal-to-noise ratio. A different approach is investigated in this paper.Methods.We developed a general temporal-unbinned method to identify flaring periods in time-tagged data and discriminate statistically significant flares. We propose an event clustering method in one dimension to identify flaring episodes, and scan statistics to evaluate the flare significance within the whole data sample. This is a photometric algorithm. The comparison of the photometric results (e.g. photometric flux, gamma-ray spatial distribution) for the identified peaks with the standard likelihood analysis for the same period is mandatory to establish if source confusion is spoiling results.Results.The procedure can be applied to reveal flares in any time-tagged data sample. The result of the proposed method is similar to a photometric light curve, but peaks are resolved, they are statistically significant within the whole period of investigation, and peak detection capability does not suffer time-binning related issues. The study of the gamma ray activity of 3C 454.3 and of the fast variability of the Crab Nebula are shown as examples. The method can be applied for gamma-ray sources of known celestial position, for example, sources taken from a catalogue. Furthermore the method can be used when it is necessary to assess the statistical significance within the whole period of investigation of a flare from an unknown gamma-ray source. Extensive results based on this analysis method for some astrophysical problems are the subject of a forthcoming paper.
Management of a Previously Coiled Anterior Cerebral Artery Aneurysm in a Child: 3-Dimensional Operative Video
Authors: Agarwal Vijay , Barrow Daniel L 
Published: March 2018

Abstract
We present the case of an 11-yr-old male who originally presented to an outside hospital with subarachnoid hemorrhage. He was discovered at that time to have a ruptured right A1-A2 junction anterior cerebral artery aneurysm just proximal to the anterior communicating artery. He underwent endovascular coiling at the outside center. While recovering at a rehabilitation center, he had a rehemorrhage and acute neurological decline. He was transferred to our service, where he underwent surgical exploration and clip reconstruction of what appeared to be a pseudoaneurysm. After a frontotemporal exposure, the right A1 segment was identified at the carotid bifurcation and followed medially. The aneurysm was significantly larger than on the original angiogram and the wall of the aneurysm was extraordinarily thin, consistent with a pseudoaneurysm. A small portion of the gyrus rectus was removed to expose the A2 segments and the remainder of the large, partially thrombosed and coiled sac of the aneurysm. Thrombus and the previously placed coils were removed in a piecemeal fashion. Two fenestrated clips were used to reconstruct the right A1, with the blades used to bring together normal tissue on the ventral surface to create a new lumen. A Doppler ultrasound was used to insunate both A1s and A2s to confirm patency. Intraoperative cerebral angiogram showed complete obliteration of the aneurysm and excellent reconstruction of the anterior cerebral complex.
The patient did very well and was neurologically intact on discharge.
All appropriate patient consents were obtained for this submission.
Microsurgical Resection of a Large Intraventricular Trigonal Tumor: 3-Dimensional Operative Video
Authors: Cheng Chun-Yu , Shetty Rakshith , Sekhar Laligam N 
Published: March 2018

Abstract
A 62-yr-old woman presented with incidentally detected left trigonal mass by magnetic resonance imaging (MRI) performed during workup for left-sided hearing loss and vertigo of 5-yr duration. Due to persistent dizziness, headache, and progressive enlargement of the tumor in follow-up scans, operation was planned. Because the tumor extended superiorly, a superior parietal lobule approach was selected.
She underwent a left parietal craniotomy. A strip electrode was used to localize the motor and sensory regions, and neuronavigation was used to confirm the entry site. A small transsulcal corticotomy was performed posterior to a large cortical vein. The tumor was pinkish in color with a well-defined capsule. It was centrally debulked by using curettes, pituitary forceps, and the ultrasonic aspirator. Tumoral blood supply from the choroid plexus and the posterior choroidal vessels were cauterized and divided. Additional blood supply coming from the anterior choroidal vessels was also found and cauterized. After circumferential dissection of the tumor capsule, the tumor was removed completely. The pathology indicated WHO Grade I meningioma. The patient had mild expressive and receptive aphasia postoperatively, but improved progressively. The postoperative MRI showed total resection with no evidence of brain injury. At 3-mo follow-up, the speech was normal; she was independent for all daily activities, but had not yet returned to work (Karnofsky score 80).
This 3-D video shows the technical nuances of microsurgical resection of an intraventricular tumor through a narrow brain corridor.
Informed consent was obtained from the patient prior to the surgery that included videotaping of the procedure and its distribution for educational purposes. All relevant patient identifiers have also been removed from the video and accompanying radiology slides.
Sex differences in gene expression in response to ischemia in the human myocardium
Authors: Stone Gregory , Choi Ashley , Oliva Meritxell , Gorham Joshua , Heydarpour Mahyar , Seidman Christine E. , Seidman Jon G. , Aranki Sary F. , Body Simon C. , Carey Vincent J. , Raby Benjamin A. , Stranger Barbara E. , Muehlschlegel Jochen D. 
Published: March 2018

Abstract and KeywordsBackgroundSex differences exist in the prevalence, presentation, and outcomes of ischemic heart disease. Females have higher risk of heart failure post myocardial infarction relative to males and the female sex is an independent risk factor for hospital and operative mortality after cardiac surgery. However, the mechanisms underlying this sexual dimorphism remain unclear. We examined sex differences in human myocardial gene expression in response to ischemia.MethodsLeft ventricular biopsies from 68 male and 46 female patients undergoing aortic valve replacement surgery were obtained at baseline and after a median 74 minutes of cold cardioplegic arrest/ischemia and respective transcriptomes were quantified by RNA-Seq. Sex-specific responses to ischemia were quantified by differential gene expression, expression quantitative trait loci (eQTL) and pathway and functional analysis. Cell-type enrichment analysis. was used to obtain an estimate of the identity and relative proportions of different cell types present in each sample.ResultsA sex-specific response to ischemia was observed for 271 genes. Functional annotation analysis revealed sex-specific modulation of the oxytocin signaling pathway and common pathway of fibrin clot formation. The eQTL analysis identified variant-by-sex interaction eQTLs at baseline and post-ischemia, indicative of sex differences in the genotypic effects on gene expression, and cell-type enrichment analysis showed sex-bias in proportion of specific cell types.ConclusionIn response to myocardial ischemia, the human left ventricle demonstrates changes in gene expression that differ between the sexes. These differences provide insight into the sexual dimorphism of ischemic heart disease and may aid in the development of sex-specific therapies that reduce myocardial injury.
Functional Pathways of Biomolecules Retrieved from Single-particle Snapshots
Authors: Dashti A. , Shekhar M.S. , Hail D. Ben , Mashayekhi G. , Schwander P. , Georges A. des , Frank J. , Singharoy A. , Ourmazd A. 
Published: March 2018

AbstractWe present a new approach to determining the conformational changes associated with biological function, and demonstrate its capabilities in the context of experimental single-particle cryo-EM snapshots of ryanodine receptor (RyR1), a Ca2+-channel involved in skeletal muscle excitation/contraction coupling. These results include the detailed conformational motions associated with functional paths including transitions between energy landscapes. The functional motions differ substantially from those inferred from discrete structures, shedding new light on the gating mechanism in RyR1. The differences include the conformationally active structural domains, the nature, sequence, and extent of conformational motions involved in function, and the way allosteric signals are transduced within and between domains. The approach is general, and applicable to a wide range of systems and processes.
Endogenous miRNA sponges mediate the generation of oscillatory dynamics for a non-coding RNA network
Authors: Dhawan Andrew , Harris Adrian L. , Buffa Francesca M. , Scott Jacob G. 
Published: March 2018

AbstractOscillations are crucial to the sustenance of living organisms, across a wide variety of biological processes. In eukaryotes, oscillatory dynamics are thought to arise from interactions at the protein and RNA levels; however, the role of non-coding RNA in regulating these dynamics remains understudied. In this work, using a mathematical model, we show how non-coding RNA acting as microRNA (miRNA) sponges in a conserved miRNA - transcription factor feedback motif, can give rise to oscillatory behaviour. Control of these non-coding RNA can dynamically create oscillations or stability, and we show how this behaviour predisposes to oscillations in the stochastic limit. These results, supported by emerging evidence for the role of miRNA sponges in development, point towards key roles of different species of miRNA sponges, such as circular RNA, potentially in the maintenance of yet unexplained oscillatory behaviour. These results help to provide a paradigm for understanding functional differences between the many redundant, but distinct RNA species thought to act as miRNA sponges in nature, such as long non-coding RNA, pseudogenes, competing mRNA, circular RNA, and 3’ UTRs.Author summaryWe analyze the effects of a newly discovered species of non-coding RNA, acting as microRNA (miRNA) sponges, on intracellular signalling dynamics. We show that oscillatory behaviour can arise in a time-varying manner in an over-represented transcriptional feedback network. These results point towards novel hypotheses for the roles of different species of miRNA sponges, such as their increasingly understood role in neural development.
Chemotaxis model for human breast cancer cells based on signal-to-noise ratio
Authors: Lim S. , Nam H. , Jeon J.S. 
Published: March 2018

ABSTRACTChemotaxis, a biased migration of cells under a chemical gradient, plays a significant role in diverse biological phenomena including cancer metastasis. Stromal cells release signaling proteins to induce chemotaxis, which further causes organ-specific metastasis. Epidermal growth factor (EGF) is an example of the chemical attractants, and its gradient stimulates metastasis of breast cancer cells. Hence, the interactions between EGF and breast cancer cells have long been a subject of interest for oncologists and clinicians. However, most current approaches do not systematically separate the effects of gradient and absolute concentration of EGF on chemotaxis of breast cancer cells. In this work, we develop a theoretical model based on signal-to-noise ratio to represent stochastic properties and report our microfluidic experiments to verify the analytical predictions from the model. The results demonstrate that even under the same EGF concentration gradients, breast cancer cells can reveal distinct chemotaxis patterns at different absolute concentrations. Moreover, we found that addition of EGF receptor antibody can promote chemotaxis at a low EGF level. This apparently counterintuitive finding suggests that EGF receptor-targeted therapy may stimulate metastasis of breast cancer at a particular condition, which should be considered in anticancer drug design.