bluuebunny/crossref_metadata_2025_split huggingface dataset:
Increasing access to smoking cessation treatment among Latino smokers using case management
Authors: Cartujano-Barrera Francisco , Perales Jaime , Arana Evelyn , Cox Lisa Sanderson , Yeh Hung-Wen , Ellerbeck Edward F. , Richter Kimber P. , Cupertino Ana Paula 
Published: March 2019

AbstractIntroductionDisparities exist among Latino smokers with respect to knowledge and access to smoking cessation resources. This study tested the feasibility of using case management (CM) to increase access to pharmacotherapy and quitlines among Latino smokers.MethodsLatino smokers were randomized to CM (n = 40) or standard care (SC, n = 40). All participants received educational materials describing how to utilize pharmacy assistance for cessation pharmacotherapy and connect with quitlines. CM participants received four phone calls from staff to encourage pharmacotherapy and quitline use. At 6-months follow-up, we assessed the utilization of pharmacotherapy and quitline. Additional outcomes included self-reported smoking status and approval for pharmacotherapy assistance.ResultsUsing intention-to-treat analysis, CM produced higher utilization than SC of both pharmacotherapy (15.0% versus 2.5%; P = 0.108) and quitlines (12.5% versus 5.0%; P = 0.432), although differences were not statistically significant. Approval for pharmacotherapy assistance programs (20.0% versus 0.0%; P = 0.0005) was significantly higher for CM than SC participants. Self-reported point-prevalence smoking abstinence at 6-months were 20.0% and 17.5% for CM and SC, respectively (P = 0.775).ConclusionsCM holds promise as an effective intervention to connect Latino smokers to evidence-based cessation treatment.
Markers of HPA-axis activity and nucleic acid damage from oxidation after electroconvulsive stimulations in rats
Authors: Jorgensen Anders , Breitenstein Katrine , Kalliokoski Otto , Weimann Allan , Henriksen Trine , Poulsen Henrik Enghusen , Jorgensen Martin Balslev , Wörtwein Gitta 
Published: March 2019

AbstractObjective:Oxidative stress has been suggested to increase after electroconvulsive therapy (ECT), a treatment which continues to be the most effective for severe depression. Oxidative stress could potentially be mechanistically involved in both the therapeutic effects and side effects of ECT.Methods:We measured sensitive markers of systemic and central nervous system (CNS) oxidative stress on DNA and RNA (urinary 8-oxodG/8-oxoGuo, cerebrospinal fluid 8-oxoGuo, and brain oxoguanine glycosylase mRNA expression) in male rats subjected to electroconvulsive stimulations (ECS), an animal model of ECT. Due to the previous observations that link hypothalamic–pituitary–adrenal (HPA)-axis activity and age to DNA/RNA damage from oxidation, groups of young and middle-aged male animals were included, and markers of HPA-axis activity were measured.Results:ECS induced weight loss, increased corticosterone (only in middle-aged animals), and decreased cerebral glucocorticoid receptor mRNA expression, while largely leaving the markers of systemic and CNS DNA/RNA damage from oxidation unaltered.Conclusion:These results suggest that ECS is not associated with any lasting effects on oxidative stress on nucleic acids neither in young nor middle-aged rats.
An introduction to Bayesian inference in gravitational-wave astronomy: Parameter estimation, model selection, and hierarchical models
Authors: Thrane Eric , Talbot Colm 
Published: March 2019

AbstractThis is an introduction to Bayesian inference with a focus on hierarchical models and hyper-parameters. We write primarily for an audience of Bayesian novices, but we hope to provide useful insights for seasoned veterans as well. Examples are drawn from gravitational-wave astronomy, though we endeavour for the presentation to be understandable to a broader audience. We begin with a review of the fundamentals: likelihoods, priors, and posteriors. Next, we discuss Bayesian evidence, Bayes factors, odds ratios, and model selection. From there, we describe how posteriors are estimated using samplers such as Markov Chain Monte Carlo algorithms and nested sampling. Finally, we generalise the formalism to discuss hyper-parameters and hierarchical models. We include extensive appendices discussing the creation of credible intervals, Gaussian noise, explicit marginalisation, posterior predictive distributions, and selection effects.
An Elementary Proof of Bevan's Theorem on the Growth of Grid Classes of Permutations
Authors: Albert Michael , Vatter Vincent 
Published: March 2019

AbstractBevan established that the growth rate of a monotone grid class of permutations is equal to the square of the spectral radius of a related bipartite graph. We give an elementary and self-contained proof of a generalization of this result using only Stirling's formula, the method of Lagrange multipliers, and the singular value decomposition of matrices. Our proof relies on showing that the maximum over the space of n × n matrices with non-negative entries summing to one of a certain function of those entries, parametrized by the entries of another matrix Γ of non-negative real numbers, is equal to the square of the largest singular value of Γ and that the maximizing point can be expressed as a Hadamard product of Γ with the tensor product of singular vectors for its greatest singular value.
The shadow of the shell: a cue for a new home
Authors: Suárez-Rodríguez Monserrat , Kruesi Karla , Alcaraz Guillermina 
Published: March 2019

AbstractHermit crabs use different senses to search for and find shells. In most cases, chemical cues have been proven to act as a very efficient way of finding new shells. However, in intertidal environments, the water transports chemical signals in different directions and velocities may make it harder to track the source of the cue, so visual stimuli may be a more precise source of information. The hermit crabCalcinus californiensisshows a preference for the biconical shells ofStramonita biserialis, although the crabs may also use the less preferred shell ofNerita scabricosta. We were interested in exploring ifC. californiensisidentify the preferred shell species through vision in the absence of chemical stimuli. We presented both shell species to hermit crabs in two different sets of experiments. In one experiment, we presented to the hermit crabs real shells ofN. scabricostaandS. biserialis, and in another, we presented only the silhouettes of the same shells. The hermit crabs discriminated between the real shells and the silhouettes ofN. scabricostaandS. biserialis. Females attended with higher frequency to real shells and silhouettes ofS. biserialis; while males attended more to shells and silhouettes ofN. scabricosta. Although, larger males biased their attendance toward shells ofS. biserialis. Our results show that visual perception may be more important than we have thought in intertidal animals.
Why Ethnic Subaltern-Led Parties Crowd Out Armed Organizations: Explaining Maoist Violence in India
Authors: Chandra Kanchan , García-Ponce Omar 
Published: March 2019

AbstractThis article asks why some Indian districts experience chronic Maoist violence while others do not. The answer helps to explain India’s Maoist civil war, which is the product of the accumulation of violence in a few districts, as well as to generate a new hypothesis about the causes of civil war more generally. The authors argue that, other things equal, the emergence of subaltern-led parties at the critical juncture before armed organizations enter crowds them out: the stronger the presence of subaltern-led political parties in a district at this juncture, the lower the likelihood of experiencing chronic armed violence subsequently. They develop their argument through field research and test its main prediction using an original, district-level data set on subaltern incorporation and Maoist violence in India between 1967 and 2008. The article contributes a new, party-based explanation to the literatures on both civil war and Maoist violence in India. It also introduces new district-level data on the Maoist movement and on the incorporation of subaltern ethnic groups by political parties in India.
ON GENERALIZED THUE–MORSE FUNCTIONS AND THEIR VALUES
Authors: BADZIAHIN DZMITRY , ZORIN EVGENIY 
Published: March 2019

In this paper we extend and generalize, up to a natural bound of the method, our previous work Badziahin and Zorin [‘Thue–Morse constant is not badly approximable’, Int. Math. Res. Not. IMRN 19 (2015), 9618–9637] where we proved, among other things, that the Thue–Morse constant is not badly approximable. Here we consider Laurent series defined with infinite products $f_{d}(x)=\prod _{n=0}^{\infty }(1-x^{-d^{n}})$, $d\in \mathbb{N}$, $d\geq 2$, which generalize the generating function $f_{2}(x)$ of the Thue–Morse number, and study their continued fraction expansion. In particular, we show that the convergents of $x^{-d+1}f_{d}(x)$ have a regular structure. We also address the question of whether the corresponding Mahler numbers $f_{d}(a)\in \mathbb{R}$, $a,d\in \mathbb{N}$, $a,d\geq 2$, are badly approximable.
MONOTONE AND PSEUDO-MONOTONE EQUILIBRIUM PROBLEMS IN HADAMARD SPACES
Authors: KHATIBZADEH HADI , MOHEBBI VAHID 
Published: March 2019

AbstractAs a continuation of previous work of the first author with Ranjbar [‘A variational inequality in complete CAT(0) spaces’, J. Fixed Point Theory Appl. 17 (2015), 557–574] on a special form of variational inequalities in Hadamard spaces, in this paper we study equilibrium problems in Hadamard spaces, which extend variational inequalities and many other problems in nonlinear analysis. In this paper, first we study the existence of solutions of equilibrium problems associated with pseudo-monotone bifunctions with suitable conditions on the bifunctions in Hadamard spaces. Then, to approximate an equilibrium point, we consider the proximal point algorithm for pseudo-monotone bifunctions. We prove existence of the sequence generated by the algorithm in several cases in Hadamard spaces. Next, we introduce the resolvent of a bifunction in Hadamard spaces. We prove convergence of the resolvent to an equilibrium point. We also prove $\triangle$-convergence of the sequence generated by the proximal point algorithm to an equilibrium point of the pseudo-monotone bifunction and also the strong convergence under additional assumptions on the bifunction. Finally, we study a regularization of Halpern type and prove the strong convergence of the generated sequence to an equilibrium point without any additional assumption on the pseudo-monotone bifunction. Some examples in fixed point theory and convex minimization are also presented.
1.25 Dihydroxyvitamin D3 Attenuates Hypertrophy Markers in Cardiomyoblast H9c2 Cells: Evaluation of Sirtuin3 mRNA and Protein Level
Authors: Jahanifar Fatemeh , Astani Akram , Shekarforoosh Shahnaz , Jamhiri Mohabbat , Safari Fereshteh , Zarei Farideh , Safari Fatemeh 
Published: March 2019

Abstract. Background: The cellular and molecular mechanisms of cardioprotective effects of Vitamin D are poorly understood. Given the essential role of sirtuin-3 (SIRT3) as an endogenous negative regulator of cardiac hypertrophy, this study was designed to investigate the effect of 1, 25-dihydroxyvitamin D3 (calcitriol) on hypertrophy markers and SIRT3 mRNA and protein levels following angiotensin II induced - hypertrophy in cardiomyoblast H9c2 cells. Methods: Rat cardiomyoblast H9c2 cells were treated for 48 hr with angiotensin II alone (Ang group) or in combination with 1, 10 and 100 nM of calcitriol (C + Ang groups). Intact cells served as control (Ctl). The cell area was measured using methylene blue staining. Atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP) and SIRT3 transcription levels were measured by real time RT-PCR. SIRT3 protein expression was evaluated using western blot technique. Results: The results showed that in Ang group cell size was increase by 128.4 ± 15% (P < 0.001 vs. Ctl) whereas in C100 + Ang group it was increased by 21.3 ± 6% (P < 0.001 vs. Ang group). Calcitriol pretreatment decreased ANP mRNA level significantly (P < 0.05) in comparison with Ang group (Ang: 75.5 ± 15%, C100 + Ang: 19.2 ± 9%). There were no significant differences between Ang group and cells pretreated with 1 and 10 nM of calcitriol. SIRT3 at mRNA and protein levels did not change significantly among the experimental groups. Conclusions: In conclusion, pretreatment with calcitriol (100 nM) prevents Ang II-induced hypertrophy in cardiomyoblast H9c2 cells. This probably occurs through other pathways except SIRT3 upregulation.
Estimating Climate Feedbacks Using a Neural Network
Authors: Zhu Tingting , Huang Yi , Wei Haikun 
Published: March 2019

AbstractA nonlinear method has been developed to estimate climate feedbacks based on the Neural Network (NN) taking advantage of its self‐learning skills. The NN model developed here is trained using a reanalysis data set and predicts radiation flux globally from atmospheric and surface variables. The radiative feedbacks of temperature, water vapor, surface albedo, and cloud in the interannual climate variations estimated from the NN method are in agreement with those from a broadly used kernel method. However, the NN method demonstrates significant advantages: (1) it withdraws the linearity assumption of the kernel method and accounts for the nonlinear effects of the feedbacks. In the case of large climate perturbations, such as that in the Arctic caused by sea ice melt, the NN method achieves better radiation closure. (2) The method can directly calculate the radiative feedback of cloud and its components. We find that the high, middle, and low cloud feedback components analyzed from the NN method are linearly additive in the interannual climate variations, although there is a considerable nonlinear effect arising from the interactions between cloud and noncloud variables.
Model Variable Augmentation (MVA) for Diagnostic Assessment of Sensitivity Analysis Results
Authors: Mai Juliane , Tolson Bryan A. 
Published: March 2019

AbstractSensitivity analysis (SA) is a critical part in the construction of all models, including environmental and water resources simulation models. For example, SA functions to characterize which model inputs the model outputs are overly sensitive or insensitive to. However, the quality of SA results is rarely assessed. If assessed, bootstrapping of the sensitivity results is used to determine the reliability of the SA output. Bootstrapping, however, is known to be inappropriate with small sample sizes. In contrast, increasing model computational burdens continues to drive researchers to apply existing SA techniques and develop new ones, with smaller and smaller sample sizes. The new Model Variable Augmentation (MVA) approach is therefore introduced here to assess the quality of SA results without performing any additional model runs or requiring bootstrapping. MVA augments the original model input variables with additional variables of known properties. The sensitivities of the augmented model variables are used to draw conclusions on the reliability of the other “original” model parameters' sensitivities. The MVA method is applied to two global SA methods: the variance‐based Sobol' method and the moment‐independent PAWN method. MVA is scrutinized using analytical benchmark functions and then used to quality check sensitivity results of two hydrologic models. Results show the following: (1) MVA is a framework to quality check the implementation of a SA method; (2) for Sobol' and PAWN analyses, MVA‐assisted ranking of input sensitivity measures outperforms the standard ranking procedure without MVA; and (3) MVA provides reasonable estimation of the uncertainty of sensitivity estimates.
Climate Factors Leading to Asymmetric Extreme Capture in the Tree‐Ring Record
Authors: Wise Erika K. , Dannenberg Matthew P. 
Published: March 2019

AbstractPaleoclimate data play a critical role in contextualizing recent hydroclimate extremes, but asymmetries in tree‐ring responses to extreme climate conditions pose challenges for reconstruction and interpretation of past climate. Here we establish the extent to which existing tree‐ring records capture precipitation extremes in western North America and evaluate climate factors hypothesized to lead to asymmetric extreme capture, including timing of precipitation, seasonal temperatures, snowpack, and atmospheric river events. We find that while there is dry‐biased asymmetry in one third of western North American tree‐ring records, 45% of sites capture wet extremes as well as or better than dry extremes. Summer extremes are rarely captured at any sites. Latitude and elevation affect site‐level extreme responses, as do seasonal climate conditions, particularly in the autumn and spring. Directly addressing asymmetric extreme value capture in tree‐ring records can aid our interpretation of past climate and help identify alternative avenues for future reconstructions.
Temporal dynamics of immune response following prolonged myocardial ischemia/reperfusion with and without cyclosporine A
Authors: Rusinkevich Vitali , Huang Yin , Chen Zhong-yan , Qiang Wu , Wang Yi-gang , Shi Yu-fang , Yang Huang-tian 
Published: March 2019

AbstractUnderstanding the dynamics of the immune response following late myocardial reperfusion is critical for the development of immunomodulatory therapy for myocardial infarction (MI). Cyclosporine A (CSA) possesses multiple therapeutic applications for MI, but its effects on the inflammation caused by acute MI are not clear. This study aimed to determine the dynamics of the immune response following myocardial ischemia/reperfusion (I/R) and the effects of CSA in a mouse model of prolonged myocardial ischemia designated to represent the human condition of late reperfusion. Adult C57BL/6 mice were subjected to 90 min of closed-chest myocardial I/R, which induced severe myocardial injury and excessive inflammation in the heart. Multicomponent analysis of the immune response caused by prolonged I/R revealed that the peak of cytokines/chemokines in the systemic circulation was synchronized with the maximal influx of neutrophils and T-cells in the heart 1 day after MI. The peak of cytokine/chemokine secretion in the infarcted heart coincided with the maximal macrophage and natural killer cell infiltration on day 3 after MI. The cellular composition of the mediastinal lymph nodes changed similarly to that of the infarcted hearts. CSA (10 mg/kg/day) given after prolonged I/R impaired heart function, enlarged the resulting scar, and reduced heart vascularization. It did not change the content of immune cells in hearts exposed to prolonged I/R, but the levels of MCP-1 and MIP-1α (hearts) and IL-12 (hearts and serum) were significantly reduced in the CSA-treated group in comparison to the untreated group, indicating alterations in immune cell function. Our findings provide new knowledge necessary for the development of immunomodulatory therapy targeting the immune response after prolonged myocardial ischemia/reperfusion.
Inverse resource allocation between vision and olfaction across the genus Drosophila
Authors: Keesey Ian W. , Grabe Veit , Gruber Lydia , Koerte Sarah , Obiero George F. , Bolton Grant , Khallaf Mohammed A. , Kunert Grit , Lavista-Llanos Sofia , Valenzano Dario Riccardo , Rybak Jürgen , Barrett Bruce A. , Knaden Markus , Hansson Bill S. 
Published: March 2019

AbstractDivergent populations across different environments are exposed to critical sensory information related to locating a host or mate, as well as avoiding predators and pathogens. These sensory signals generate evolutionary changes in neuroanatomy and behavior; however, few studies have investigated patterns of neural architecture that occur between sensory systems, or that occur within large groups of closely-related organisms. Here we examine 62 species within the genus Drosophila and describe an inverse resource allocation between vision and olfaction, which we consistently observe at the periphery, within the brain, as well as during larval development. This sensory variation was noted across the entire genus and appears to represent repeated, independent evolutionary events, where one sensory modality is consistently selected for at the expense of the other. Moreover, we provide evidence of a developmental genetic constraint through the sharing of a single larval structure, the eye-antennal imaginal disc. In addition, we examine the ecological implications of visual or olfactory bias, including the potential impact on host-navigation and courtship.
Human olfactory-auditory integration requires phase synchrony between sensory cortices
Authors: Zhou Guangyu , Lane Gregory , Noto Torben , Arabkheradmand Ghazaleh , Gottfried Jay A. , Schuele Stephan U. , Rosenow Joshua M. , Olofsson Jonas K. , Wilson Donald A. , Zelano Christina 
Published: March 2019

AbstractMultisensory integration is particularly important in the human olfactory system, which is highly dependent on non-olfactory cues, yet its underlying neural mechanisms are not well understood. In this study, we use intracranial electroencephalography techniques to record neural activity in auditory and olfactory cortices during an auditory-olfactory matching task. Spoken cues evoke phase locking between low frequency oscillations in auditory and olfactory cortices prior to odor arrival. This phase synchrony occurs only when the participant’s later response is correct. Furthermore, the phase of low frequency oscillations in both auditory and olfactory cortical areas couples to the amplitude of high-frequency oscillations in olfactory cortex during correct trials. These findings suggest that phase synchrony is a fundamental mechanism for integrating cross-modal odor processing and highlight an important role for primary olfactory cortical areas in multisensory integration with the olfactory system.
Thermodynamically stable whilst kinetically labile coordination bonds lead to strong and tough self-healing polymers
Authors: Lai Jian-Cheng , Jia Xiao-Yong , Wang Da-Peng , Deng Yi-Bing , Zheng Peng , Li Cheng-Hui , Zuo Jing-Lin , Bao Zhenan 
Published: March 2019

AbstractThere is often a trade-off between mechanical properties (modulus and toughness) and dynamic self-healing. Here we report the design and synthesis of a polymer containing thermodynamically stable whilst kinetically labile coordination complex to address this conundrum. The Zn-Hbimcp (Hbimcp = 2,6-bis((imino)methyl)-4-chlorophenol) coordination bond used in this work has a relatively large association constant (2.2 × 1011) but also undergoes fast and reversible intra- and inter-molecular ligand exchange processes. The as-prepared Zn(Hbimcp)2-PDMS polymer is highly stretchable (up to 2400% strain) with a high toughness of 29.3 MJ m−3, and can autonomously self-heal at room temperature. Control experiments showed that the optimal combination of its bond strength and bond dynamics is responsible for the material’s mechanical toughness and self-healing property. This molecular design concept points out a promising direction for the preparation of self-healing polymers with excellent mechanical properties. We further show this type of polymer can be potentially used as energy absorbing material.