bluuebunny/crossref_metadata_2025_split huggingface dataset:
Recording Vital and Laboratory Parameters and the Risk of Death in Children Admitted to First- and Second-Level Hospitals for Emergency Medical Care: A Case-Control Study
Authors: Prometnoy Dmitry V. , Aleksandrovich Yuriy S. , Pshenisnov Konstantin V. , Teplyakova Helen D. , Razumov Sergey A. 
Published: January 2019

Background. Diagnostic mistakes due to incomplete examination of patients are the leading cause of death. The prevalence of such mistakes and their association with treatment outcomes in our country remain uninvestigated.Objective. Our aim was to study the frequency of recording vital and laboratory parameters and its relationship with death in children admitted to a hospital for emergency medical care.Methods. In our case-control study we analysed the data of medical records of an inpatient (Form 003/u) — patients for intensive care at the age of 0–17 years who were admitted to first-level (n = 13) and second-level (n = 5) hospitals of the Rostov Region (except for Rostov-on-Don) in 2006–2017. We considered the frequency of recording vital (heart rate, respiration rate; blood pressure; oxygen saturation of arterial blood; body temperature) and laboratory (blood count, haemoglobin, hematocrit, total protein, glucose, urea, creatinine, pH, pCO2, pO2, BE, sodium and potassium levels) parameters upon admission to in-patient hospital and when transferred to the intensive care unit (ICU). The association of the frequency of recording these parameters with hospital outcome was assessed using multivariate logistic regression analysis adjusted for the effect of confounders (consultation by a resuscitationist of the resuscitation and consultation centre; the level of healthcare facility; admission time; the presence of infectious diseases and diseases that occurred in the perinatal period; the level of consciousness; the duration of the underlying disease before admission; the method of admission to a healthcare facility).Results. We studied the data of 61 children with a favourable (discharged from healthcare facilities) and 90 children with a fatal outcome in the in-patient hospital (76 — in the ICU). A fatal outcome in the in-patient hospital was associated with records of BE [odds ratio (OR) 3.25; 95% confidence interval (CI) 1.25–8.46)], total protein level (OR 0.19; 95% CI 0.05–0.79), urea (OR 0.24; 95% CI 0.06–0.87) and creatinine (OR 0.23; 95% CI 0.08–0.67) upon admission. A fatal outcome in the ICU was associated with records of systolic (OR 0.36; 95% CI 0.14–0.94) and diastolic (OR 0.30; 95% CI 0.12–0.80) blood pressure, SpO2 (OR 0.38; 95% CI 0.15–0.93) and body temperature (OR 0.32; 95% CI 0.11–0.90) upon admission to the unit.Conclusion. The association of the outcome with recording of vital (blood pressure, SpO2 and body temperature upon admission to the ICU) and laboratory (BE, total protein, urea, creatinine upon admission to a healthcare facility) parameters in children admitted to a hospital for emergency medical care indicates the need to control their clinical and paraclinic examination. A more complete examination of these children may be a reserve for reducing hospital mortality.
Aortic valve replacement in elderly and advanced age patients: analysis of preoperative risk factors
Authors: Skopin I. I. , Otarov A. M. , Kakhktsyan P. V. , Asatryan T. V. , Kurbanov Sh. M. , Paronyan Kh. V. 
Published: February 2019

Background.Despite an increase in the number of surgeries performed in elderly patients, conventional aortic valve replacement is associated with high postoperative mortality in comparison to young adults. The risk of surgical intervention in elderly patients is associated not only with the age, but also with the presence of a large number of concomitant diseases.Aim.To evaluate the immediate results of conventional aortic valve replacement and assess the impact of preoperative risk factors on surgical treatment.Methods.A retrospective analysis of the results of aortic valve replacement was performed in patients older than 65 years operated in the period from 2011 to 2015 (a total of 253 cases). The mean age of the patients was 70.4±4.14 years. The mean EuroSCORE was 6.09±4.45%. The impact of more than 30 preoperative risk factors on the in-hospital mortality and development of postoperative complications has been analyzed.Results.The overall in-hospital mortality was 10.3%. In-hospital mortality of isolated aortic valve replacement was 4.8%. In-hospital mortality of aortic valve replacement combined with coronary artery bypass grafting was 8.8%. High postoperative mortality rate was reliably associated with the urgency of surgery, a positive history of stroke, obesity, chronic renal failure, chronic obstructive pulmonary disease, pulmonary hypertension, a positive history of malignant neoplasms, polyvascular disease, pre-operative atrial fibrillation, IV class NYHA, post-stenotic aortic dilation, severe calcification, small aortic root.Conclusion.Aortic valve replacement in elderly and advanced age patients have relatively similar results to those of the younger patients. High risk of surgery in advanced age patients is mainly associated with the presence of concomitant extracardiac pathology and preoperative risk factors.
Public Procedures for State Registration
Authors: Agapov A. A. 
Published: February 2019

The paper reviews the types of state registration carried out to meet private and public needs, as well as the content of the relevant administrative procedures. The author substantiates the conclusion concerning the public purpose of the state registration referred to the jurisdiction of the federal executive authorities and other public bodies. Special attention is paid to the state registration of independent contractor agreements and public deals. The paper considers the content of the state registration under administrative law as it is established in relation to the objects of intellectual property, possession, use and disposal of individual real estate objects, as well as movable things. Also, the registration relations caused by law enforcement needs are analyzed. The paper substantiates the classification of types of state registration depending on the goalsetting, the essence of registration procedures, the status of a registering body.The content of administrative procedures arising in ordinary or extraordinary registration relations is considered in detail.Special attention is paid to tort relations in the sphere of public registration activities, indirect violations of administrative procedures by executive authorities and their authorized officials — “state registrars of rights.” Administrative procedures referred to the authority of public registration entail the emergence, modification, suspension or termination of a registration relationship and civilistic or public authority preconditioned by the registration authority.Identification of features of the offense committed by the registration authority entails compensation of property damage and moral damage and damage to reputation.Not only a specific thing with its expressed property and commodity properties, but also an intangible substance, primarily an object of intellectual property, can be an object of state registration. The public purpose of state registration is preconditioned by protection of non-public rights and interests of a business entity or a participant of a non-profit activity.The content of administrative procedures of state registration in the sphere of law enforcement is considered in detail.
The Basis of Criminal Responsibility
Authors: Blagov E. V. 
Published: February 2019

Despite the importance for criminal law, the basis of criminal liability remains quite controversial in the criminal law science. At the same time, it has been studied in numerous sources. However, instead of analyzing criminal law, many authors consider it their duty to first share their own ideas about the basis of criminal responsibility, regardless of the actual content of the law.This article is structured differently. It attempts to understand what the norm-maker himself meant when formulating the provisions of art. 8 of the Criminal Code of the Russian Federation. The author finds it necessary to identify and analyze the features introduced by him as the basis of criminal responsibility. At the same time, the views on the basis of criminal responsibility existing in the theory of criminal law are critically examined, the failure of both this basis and the wording of art. 8 of the Criminal Code of the Russian Federation is recognized. The author expresses agreement with the logic of the introduction of a two-pronged basis of criminal responsibility provided by legislators. Based on the study the author proposes and justifies a new solution that better meets the urgent needs of the practice of criminal law implementation.
Self-Organising Systems in the Context of Academic Environment
Authors: Kuprina T. V. , Beketova A. P. , Minasyan S. M. 
Published: February 2019

Introduction.In the era of globalisation, which affects all spheres of modern social life (political, financial, scientific, technical, religious, cultural), the processes of internationalisation and academic migration in higher education have significantly intensified. The rapidly growing mobility in higher education, when students study outside their country of residence, is accompanied by certain problems, which include students’ adaptation to the conditions of unfamiliar urban environment. The introduction of new methodological tools for teaching humanitarian disciplines in universities can contribute to the elimination of barriers and successful transition of students to another, different from their customary, socio-cultural environment.The aimof the research was to present the results of experimental work aimed at the development of students’ intercultural communicative tolerance within the foreign language learning, and to reveal the role of self-organising systems in the university international academic environment.Methodology and research methods. The study is based on the theory of self-organising systems. In the process of designing and application of the authors’ technology aimed at developing students’ intercultural communicative tolerance, experimental methods and the method of comparative analysis were used.Results and scientific novelty.It has been shown that academic migration is a self-organising system characterised by socio-cultural instability. The factors of human transition from one urboecological niche to another, which often disturbs the balance of social systems, have been described. Lacking knowledge about such processes in the theory and practice of pedagogy within higher education has been stated. Insufficient level of intercultural communicative tolerance of Russian (132 people) and foreign (40 people) students, who studied at the Ural Federal University (Ekaterinburg, Russia) in 2015, has proved the necessity of its systematic focused formation. The technology for the development of this type of tolerance within the framework of the ‘Foreign Language’ discipline has been proposed. The approbation of the technology has demonstrated its effectiveness. The students have not only acquired the necessary competencies, but also learned to adapt to the new academic environment, as well as had the opportunity to directly participate in the creation of their own academic programs.Practical significance.The research confirms the productivity of mutual adaptation of students to an unfamiliar socio-cultural academic environment. The author’s technology of intercultural communicative tolerance development can be used to optimise the pedagogical conditions of maintaining the processes of internationalisation and academic mobility within universities.
Scientometric analysis of evidence-based studies of rehabilitation physical factors for breast cancer patients
Authors: Kasparov B. S. , Semiglazova T. Yu. , Kovlen D. V. , Ponomarenko G. N. , Klyuge V. A. , Krutov A. A. , Zernova M. A. , Kondratieva K. O. , Adkhamov B. M. , Semiglazov V. V. , Belyaev A. M. 
Published: February 2019

During last 10 years the number of studies which devoted to using of medical physical factors in rehabilitation of patients with breast cancer has increased. Using any physical factor in rehabilitation should be proved by results of evidence-based studies.The article presents data of scientometric analysis of 748 studies from 1980 till 2018 which were devoted to using of medical physical factors in rehabilitation of 261643 patients with breast cancer. The most studied physical factors with authentically proven effect are physical exercises, water based physical exercises, compression therapy. Process of synthesis and analysis of study results should be done regularly.
Phytochemical Evaluation of Morus alba Seeds and Cold Pressed Oil
Authors: ÜSTÜN ARGON Zeliha , İLHAN Nihal , GÖKYER Ali , BÜYÜKHELVACIGİL ÖZTÜRK Sıdıka , KOPARAL Beril 
Published: January 2019

This study has focused on Morus alba, which is grown in Turkey mostly for fruit production. M. alba seeds’ analysis results showed that oil, protein, ash, ash insoluble in hydrochloric acid, total carbohydrate were 21%, 21.58±0.13g, 3.99±0.13g, 0.9±0.00g, 54.76±2.42 g/100g respectively, main minerals were calcium, phosphorus and potassium. Dominated fatty acids were linoleic acid (80.56±0.22), palmitic acid (7.96±0.06), oleic acid (7.11±0.05). The primary volatiles were l-limonene, 2,2-dimethyldecane, hexanal. Sterol components were found as beta-sitosterol&gt;delta-5-avenasterol&gt;campesterol&gt;cholestanol with 5501.49±44.26 mg/kg total sterols. Tocopherols were δ-tocopherol, γ-tocopherol, β-tocopherol, α-tocopherol, total phenolic content, the radical scavenging activity were 257.67±4.51, 18.23±0.11, 6.71±0.13, 3.23±0.06 mg/kg, 137.1±0.36 mgGAE/100goil, 19.9±0.46% respectively. Other physicochemical properties were free fatty acid (1.55±0.89% oleic acid), peroxide value (3.23±0.55 meqO2/kg oil), p-anisidine value (1.18±0.55) and refractive index (400C) (1.4687±0.00). As a result, M. alba seeds and oil with its fatty acid, tocopherol, sterol and mineral composition can be used as nutritional supplements.
THE RELATIONSHIP MODEL AMONG OSH CLIMATE TO PREVENT NEEDLE STICK INJURY FOR NURSE
Authors: Ismara Ketut Ima , Husodo Adi Heru , Prabandari Yayi Suryo , Hariyono Widodo 
Published: February 2019

Purpose: Finding out the relationship model among the climate of Occupational Safety & Health (OSH), behavior intention on OSH performance to prevent the needlestick injury (NSI) based on (TPB) Theory Planed Behaviour. Method: using a mixed method approach of qualitative and quantitative. Data from the questionnaires of SEM, observation, documentation and interviews were analyzed qualitatively. The population was all nurses at Hospiltal of dr.Sardjito in Yogyakarta, the sample consisted of 289 respondents of purposive random with the accuracy level of 5%. Result: OSH climate consisting of attitude, norm and Perceived Behavior Control (PBC) effect on intention (safety intention). Indirect OSH climate influence on safety performance, but it must through intention. Intention directly affects safety performance in the form of behavior to implement NSI prevention procedure (NSI). Conclusion: attitudes to risk, attitudes to leader’s commitment as role models, and group norms, as well as beliefs in the ability to perform safety & health procedures determine the safety climate that will lead to an intention to safety & health behavior as OSH performance. The procedures preparation and implementation of NSI prevention should consider the model of this research result in order to work safely and healthy.
Impacto de la norma social subjetiva en la intención de emprendimiento sostenible: un caso de estudio con estudiantes colombianos
Authors: Gálvez-Albarracín Edgar Julián , Guauña-Aguilar Rafael Andrés , Pérez-Uribe Rafael Ignacio 
Published: February 2019

Rev.esc.adm.neg
El objetivo de este artículo, basado en la investigación científica que lo sustenta, es aportar nuevas evidencias en el campo del emprendimiento relacionado con sostenibilidad, las intenciones emprendedoras y la creación de empresas en estudiantes universitarios, en el Valle del Cauca. Se trabajó con una muestra de 246 estudiantes de contaduría pública y administración de empresas de la Universidad del Valle, Sede Norte del Cauca. Los resultados señalan que el 70% de alumnos estaban interesados en ser empresarios con enfoque sostenible, siendo la variable con mejor valoración el apoyo de la familia y que a mejor percepción de la norma subjetiva mayor intención emprendedora sostenible en las personas. De esta manera se comprobó la hipótesis formulada: cuanto mayor es en los estudiantes la percepción de una positiva valoración social respecto a la creación de empresas sostenibles, mayor es su actitud emprendedora
Enseñanza del emprendimiento en la educación superior: ¿Metodología o modelo?
Authors: Saldarriaga Salazar María Eugenia , Guzmán González María Fernanda 
Published: February 2019

Rev.esc.adm.neg
En el presente documento se presentan los resultados de un análisis de metodologías y modelos para la enseñanza del emprendimiento utilizadas en algunas universidades, entre los años 2008-2016. Para tal fin, se realizó una búsqueda de información sobre algunas universidades europeas, americanas, latinoamericanas, colombianas y del departamento del Cauca que incluyen el emprendimiento dentro de sus planes de estudio en diversas áreas.Luego de ello, se clasificó y analizó la información hallada y por último se identificaron las similitudes y diferencias existentes. Se encontró entonces que no son ni metodologías ni modelos lo que la mayoría de las universidades emplea para la orientación del emprendimiento, aunque algunas han hecho una recopilación de información para poder apropiar una metodología de enseñanza del emprendimiento.
CASSETTE - clindamycin adjunctive therapy for severe Staphylococcus aureus treatment evaluation: study protocol for a randomised controlled trial
Authors: Dotel Ravindra , Tong Steven YC , Bowen Asha , Nelson Jane N , O'Sullivan Matthew VN , Campbell Anita J , McMullan Brendan J , Britton Philip N , Francis Joshua R , Eisen Damon P , Robinson Owen , Manning Laurens , Davis Joshua S 
Published: January 2019

Abstract
Background: Exotoxins are an important virulence factors in Staphylococcus aureus. Clindamycin, a protein synthesis inhibitor antibiotic, is thought to limit exotoxin production and improve outcomes in severe S. aureus infections. However, randomised prospective data to support this is lacking.
Methods: An open label, multicenter, randomised controlled trial (RCT) will compare outcome differences in severe S. aureus infection between a standard treatment (flucloxacillin/cefazolin in methicillin-susceptible S. aureus; and vancomycin/daptomycin in methicillin-resistance S. aureus) and a standard treatment plus an additional clindamycin given for 7 days. We will include a minimum of 60 participants (both adult and children) in the pilot study. Participants will be enrolled within 72 hours of an index culture. Severe infections will include septic shock, necrotising pneumonia, or multifocal and non-contiguous skin and soft tissue/osteoarticular infections. Immunosuppressed, moribund, current severe diarrhea or C. difficile infection, pregnant, and those with anaphylaxis to beta-lactams or lincosamides will be excluded. Primary outcomes measure is number of days alive and free (1 or none) of SIRS (Systemic Inflammatory Response Syndrome) within the first 14 days post randomization. Secondary outcomes measure will include all-cause mortality at 14, 42 and 90 days, time to resolution of SIRS, proportion with microbiological treatment failure, and rate of change of C-reactive protein over time. Impacts of inducible clindamycin resistance, strains types, methicillin-susceptibility, and presence of various exotoxins will also be analysed.
Discussion: This study will assess the effect of adjunctive clindamycin on patient-centered outcomes in severe, toxin mediated S. aureus infections. The Pilot study will provide feasibility for a much larger RCT.
Trial Registration: Australian New Zealand Clinical Trials Registry: ACTRN12617001416381p. Registered 06 October 2017
Keywords: Staphylococcus aureus, exotoxins, prospective studies, clindamycin, leukocidins
Impact of physical exercise on cardiotoxicity and cardiac health outcomes in women with breast cancer undergoing anthracycline-containing chemotherapy: a study protocol for a randomized controlled trial
Authors: Antunes Pedro , Esteves Dulce , Nunes Célia , Sampaio Francisco , Ascensão Antonio , Vilela Eduardo , Teixeira Madalena , Amarelo Anabela Leal , Joaquim Ana 
Published: January 2019

Abstract
Background: Anthracyclines are chemotherapeutic agents frequently used in breast cancer (BC) treatment. Although improving disease-free and overall survival, the use of anthracyclines is associated with a cumulative risk of cardiac toxicity. Preventive strategies to optimize and balance cardiac health are needed, being exercise proposed as a potential non-pharmacological approach for counteracting of anthracycline-related cardiotoxicity (ARC). Despite most of the data analysing the role of exercise against cardiac toxicity and dysfunction caused by anthracyclines derived from animal studies, human studies claim for more accurate and valuable clinical biomarkers. Moreover, clinical trials in real-world setting and large samples are of pivotal importance.
Methods: This protocol describes a two-arm prospective randomized controlled trial that will explore the cardioprotective effect of a structured exercise program against ARC in women with BC. Eighty-six adult women with early BC and with a therapeutic decision to receive anthracycline-containing chemotherapy (ACT) will be randomly assigned (1:1) to an intervention group or to a control group. Patients allocated to the intervention group will perform a 3-weekly supervised exercise program combining resistance and aerobic training with progressive intensity (light-to-vigorous), during the overall ACT. The control group will receive standard BC care. Primary outcomes related to cardiac (dys)function will be circulating N-terminal pro-brain natriuretic peptide (NT-proBNP) levels, resting left ventricular (LV) longitudinal strain, and resting LV ejection fraction. Secondary outcomes will include the assessment of resting blood pressure, resting heart rate (HR), resting HR variability (HRV) and recovery HR. Exploratory outcomes include physical function outcomes, self-reported physical activity level, health related to quality of life and fatigue. Data will be obtained at baseline (t0), after the end of anthracycline-treatment (t1), and three months after t2 (t2). Additionally, NT-proBNP levels will be measured between 1-24 hours prior to each anthracycline-treatment cycle.
Discussion: The implementation of the present study design, using novel clinical biomarkers and “between” outcomes’ associations, will help to understand the effectiveness of structured exercise interventions at mitigating ARC, further contributing to the improvement of supportive cancer care.
Trial registration: ISRCTN, ISRCTN32617901. Registered on 24 October 2018. Last updated on 11 January 2019, https://doi.org/10.1186/ISRCTN32617901.
Keywords: Breast cancer, cardiotoxicity, cardiac healthcare, supervised exercise, supportive cancer care.