bluuebunny/crossref_metadata_2025_split huggingface dataset:
Anterior Cruciate Ligament Injury—Who Succeeds Without Reconstructive Surgery? The Delaware-Oslo ACL Cohort Study
Authors: Grindem Hege , Wellsandt Elizabeth , Failla Mathew , Snyder-Mackler Lynn , Risberg May Arna 
Published: May 2018

Background: More than 50% of highly active patients with an anterior cruciate ligament (ACL) injury who choose nonsurgical treatment (active rehabilitation alone) have successful 2-year outcomes and comparable knee function to an uninjured population. Early predictive factors for a successful outcome may aid treatment decision making in this population. Purpose: To identify early predictors of a successful 2-year outcome in those who choose nonsurgical treatment of an ACL injury. Study Design: Cohort study; Level of evidence, 2. Methods: This prospective cohort study consisted of ACL-injured athletes who were consecutively screened for inclusion. A total of 300 patients were included from 2 sites (Oslo, Norway, and Delaware, USA), and the 118 patients who initially chose not to undergo ACL reconstruction were included. All patients participated in pivoting sports before the injury, and none had significant concomitant injuries. A successful 2-year outcome was defined as having 2-year International Knee Documentation Committee (IKDC) scores ≥15th normative percentile and not undergoing ACL reconstruction. Multivariable logistic regression models were built using demographic and knee function data (quadriceps muscle strength, 4 single-leg hop tests, IKDC score, and Knee Outcome Survey–Activities of Daily Living Scale [KOS-ADLS] score) collected at baseline or after a 5-week neuromuscular and strength training (NMST) rehabilitation program. Results: After 2 years, 52 of 97 (53.6%) patients had a successful outcome. In the multivariable baseline model, older age, female sex, better performance on the single-leg hop test, and a higher KOS-ADLS score were significantly associated with successful 2-year outcomes. After the 5-week NMST rehabilitation program, older age, female sex, and a higher IKDC score increased the odds of a successful 2-year outcome. The 2 models had comparable predictive accuracy (post-NMST area under the curve [AUC], 0.78 [95% CI, 0.68-0.88]; baseline AUC, 0.81 [95% CI, 0.72-0.89]). Conclusion: Clinicians and patients can be more confident in a nonsurgical treatment choice (active rehabilitation alone) in athletes who are female, are older in age, and have good knee function, as measured by single-leg hop tests and patient-reported outcome measures, early after an ACL injury. Prediction models that include measures of knee function, assessed either before or after rehabilitation, can estimate 2-year prognoses for nonsurgical treatment and thereby assist shared treatment decision making.
Borehole image electrofacies with a comparative carbonate petrography analysis: An outcrop well study associated with reservoir application in the Ordovician Tarim Basin
Authors: Nian Tao , Jiang Zaixing , Song Hongyu 
Published: May 2018

Electrical borehole image logs have the potential for direct interpretation of lithofacies characteristics. The challenge is to establish a set of reliable diagnostic criteria with which electrical images can be correlated to lithofacies features such as lithology, sedimentary structures, and bedding sequences. We used the “behind-outcrop” logging procedure that can link borehole images to actual rocks and also reduce errors that are associated with core-shift process. To better reveal the correlation between borehole images and carbonate lithofacies for subsurface reservoir applications, and also make a comparative petrographic analysis with the aim of establishing diagnostic criteria for borehole images, a 200 m well was drilled in the Tarim Ordovician outcrop. A full set of borehole image data and cores with approximately 100% coring recovery rate was acquired at the same depth interval, and more than 100 stained thin sections were prepared. Electrical borehole images in wells adjacent to the outcrop were further interpreted to validate the proposed criteria. Borehole image electrofacies were established according to the image elements, such as stacked mode, bed thickness, conglomerate diameter, rim characteristics, and internal structure of bed/conglomerate, to interpret depositional/diagenetic textures and platform-slope associations. Nine image electrofacies types, corresponding to mud/wacke/pack/grain/bindstone texture, were identified and interpreted in detail. Our method reveals a set of diagnostic criteria for borehole image interpretation in carbonate platform slope, and it finally provides a powerful tool for direct interpretation of electrical images in similar reservoir environment.
Minimally Invasive Lung Cancer Surgery Performed by Thoracic Surgeons as Effective as Thoracotomy
Authors: Boffa Daniel J. , Kosinski Andrzej S. , Furnary Anthony P. , Kim Sunghee , Onaitis Mark W. , Tong Betty C. , Cowper Patricia A. , Hoag Jessica R. , Jacobs Jeffrey P. , Wright Cameron D. , Putnam Joe B. , Fernandez Felix G. 
Published: May 2018

Purpose The prevalence of minimally invasive lung cancer surgery using video-assisted thoracic surgery (VATS) has increased dramatically over the past decade, yet recent studies have suggested that the lymph node evaluation during VATS lobectomy is inadequate. We hypothesized that the minimally invasive approach to lobectomy for stage I lung cancer resulted in a longitudinal outcome that was not inferior to thoracotomy. Patients and Methods Patients > 65 years of age who had undergone lobectomy for stage I lung cancer between 2002 and 2013 were analyzed within the Society of Thoracic Surgeons General Thoracic Surgery Database, which had been linked to Medicare data, as part of a retrospective-cohort, noninferiority study. Results A total of 10,597 patients with clinical stage I lung cancer who underwent lobectomy were evaluated (4,448 patients underwent thoracotomy, and 6,149 underwent VATS). VATS patients had a more favorable distribution of all health-related variables, including pulmonary function (59% of VATS patients had intact spirometry v 51% of thoracotomy patients; P < .001). Cox proportional hazards models were performed over two eras to account for an evolving practice standard. The mortality risk associated with the VATS approach was not greater than thoracotomy in either the earlier era (2002 to 2008; hazard ratio, 0.97; 95% CI, 0.87 to 1.09; P = .62) or the more recent era (2009 to 2013; hazard ratio, 0.84; 95% CI, 0.75 to 0.93; P < .001). Kaplan-Meier survival estimates of 2,901 propensity-matched VATS-thoracotomy pairs demonstrated that the 4-year survival associated with VATS (68.6%) was modestly superior to thoracotomy (64.8%; P = .003). The analyses detailed above were replicated in a separate cohort of pathologic stage I patients with similar findings. Conclusion The long-term efficacy of lobectomy for stage I lung cancer performed using the VATS approach by board-certified thoracic surgeons does not seem to be inferior to that of thoracotomy.
Risk-Imaging Mismatch in Cardiac Imaging Practices for Women Receiving Systemic Therapy for Early-Stage Breast Cancer: A Population-Based Cohort Study
Authors: Thavendiranathan Paaladinesh , Abdel-Qadir Husam , Fischer Hadas D. , Liu Ying , Camacho Ximena , Amir Eitan , Austin Peter C. , Lee Douglas S. 
Published: May 2018

Purpose To assess prechemotherapy cardiac imaging practices in relation to patients’ heart failure (HF) risk. Methods We performed a population-based retrospective cohort study of women receiving chemotherapy for early-stage breast cancer in Ontario between 2007 and 2012. We surveyed for baseline cardiac imaging 6 months before chemotherapy or within 30 days thereafter. The proportion of patients who underwent imaging and cumulative incidence of major adverse cardiac event (MACE) rates was determined based on chemotherapy regimen and HF risk factors. Logistic regression was used to assess predictors of pretreatment cardiac imaging. Results We studied 18,444 women who had been treated with chemotherapy (median age, 55 years). There was near-universal imaging of women treated with trastuzumab-containing regimens, including those without additional HF risk factors. Women who received anthracyclines without trastuzumab underwent imaging more frequently if they had additional HF risk factors (73.3% v 62.6%; P < .001). The 5-year incidence of MACE was two to six times higher in patients with HF risk factors across all treatment regimens. Patients with HF risk factors who received anthracyclines without trastuzumab had a higher 5-year incidence of MACE (4.5%) than patients without HF risk factors who received trastuzumab without anthracyclines (2.6%). However, cardiac imaging was less frequent in the former group (73.3% v 93.6%; P < .001). Logistic regression indicated that most variation in baseline imaging was related to chemotherapy, followed by physician-level factors. The odds of imaging were doubled with female physicians. Patient-specific factors, including HF risk factors, made minimal contribution to variation in imaging. Conclusion Baseline cardiac imaging was driven by chemotherapy regimen rather than HF risk. This risk-imaging mismatch is an impetus to reconsider current cardiac imaging practices in patients who receive chemotherapy for breast cancer.
Metastatic Pancreatic Cancer: ASCO Clinical Practice Guideline Update
Authors: Sohal Davendra P.S. , Kennedy Erin B. , Khorana Alok , Copur Mehmet S. , Crane Christopher H. , Garrido-Laguna Ignacio , Krishnamurthi Smitha , Moravek Cassadie , O’Reilly Eileen M. , Philip Philip A. , Ramanathan Ramesh K. , Ruggiero Joseph T. , Shah Manish A. , Urba Susan , Uronis Hope E. , Lau Michelle W. , Laheru Daniel 
Published: May 2018

Purpose In 2016, ASCO published a guideline to assist in clinical decision making in metastatic pancreatic cancer for initial assessment after diagnosis, first- and second-line treatment options, palliative and supportive care, and follow-up. The purpose of this update is to incorporate new evidence related to second-line therapy for patients who have experienced disease progression or intolerable toxicity during first-line therapy. Methods ASCO convened an Expert Panel to conduct a systematic review of the literature on second-line therapy published between June 2015 and January 2018. Recommendations on other topics covered in the 2016 Metastatic Pancreatic Cancer Guideline were endorsed by the Expert Panel. Results Two new studies were found that met the inclusion criteria. Recommendations For second-line therapy, gemcitabine plus nanoparticle albumin-bound paclitaxel should be offered to patients with first-line treatment with FOLFIRINOX (leucovorin, fluorouracil, irinotecan, and oxaliplatin), an Eastern Cooperative Oncology Group performance status (ECOG PS) of 0 to 1, and a favorable comorbidity profile; fluorouracil plus nanoliposomal irinotecan can be offered to patients with first-line treatment with gemcitabine plus NAB-paclitaxel, an ECOG PS of 0 to 1, and a favorable comorbidity profile; fluorouracil plus irinotecan or fluorouracil plus oxaliplatin may be offered when there is a lack of availability of fluorouracil plus nanoliposomal irinotecan; gemcitabine or fluorouracil should be offered to patients with either an ECOG PS of 2 or a comorbidity profile that precludes other regimens. Testing select patients for mismatch repair deficiency or microsatellite instability is recommended, and pembrolizumab is recommended for patients with mismatch repair deficiency or high microsatellite instability tumors. Endorsed recommendations from the 2016 version of this guideline for computed tomography, baseline performance status and comorbidity profile, defining goals of care, first-line therapy, and palliative care are also contained within the full guideline text. Additional information is available at www.asco.org/gastrointestinal-cancer-guidelines .
Conditional Deletion of FOXL2 and SMAD4 in Gonadotropes of Adult Mice Causes Isolated FSH Deficiency
Authors: Li Yining , Schang Gauthier , Wang Ying , Zhou Xiang , Levasseur Adrien , Boyer Alexandre , Deng Chu-Xia , Treier Mathias , Boehm Ulrich , Boerboom Derek , Bernard Daniel J 
Published: May 2018

AbstractThe glycoprotein FSH, a product of pituitary gonadotrope cells, regulates ovarian follicle development in females and spermatogenesis in males. FSH is a heterodimer of the common α gonadotropin subunit and the hormone-specific FSHβ subunit (a product of the Fshb gene). Using a conditional knockout approach (Cre-lox), we previously demonstrated that Fshb expression in mice depends on the transcription factors forkhead box L2 (FOXL2) and SMAD4. Deletion of Foxl2 or Smad4 alone led to FSH deficiency, female subfertility, and oligozoospermia in males. Simultaneous deletion of the two genes yielded a greater suppression of FSH and female sterility. The Cre-driver used previously was first active during embryonic development. Therefore, it is unclear whether FOXL2 and SMAD4 play important roles in the development or adult function of gonadotropes, or both. To address this question, we developed a tamoxifen-inducible Cre-driver line, which enabled Foxl2 and Smad4 gene deletions in gonadotropes of adult mice. After tamoxifen treatment, females with previously demonstrated fertility exhibited profound reductions in FSH levels, arrested ovarian follicle development, and sterility. FSH levels were comparably reduced in males 1 or 2 months after treatment; however, spermatogenesis was unaffected. These data indicate that (1) FOXL2 and SMAD4 are necessary to maintain FSH synthesis in gonadotrope cells of adult mice, (2) FSH is essential for female reproduction but appears to be unnecessary for the maintenance of spermatogenesis in adult male mice, and (3) the inducible Cre-driver line developed here provides a powerful tool to interrogate gene function in gonadotrope cells of adult mice.
The Problem of Free Will and Predestination in the Light of Satan’s Justification in Early Sufism
Authors: Basharin Pavel V. 
Published: May 2018

Abstract
This article examines the story of Iblīs’s disobedience in early Sufism. The motif of justifying and condemning Satan is a characteristic feature of the ideological heritage of some Sufis. The first Sufi line estimates Satan as a sufferer and a sacrifice of God’s predestination. Al-Ḥallāj’s teaching became the climax of this tradition for early Sufism. The second line of this discourse is connected with criticism of Satan’s role. The central figure in this process is Rūzbihān Baqlī. The genesis of this topic in early Sufism demonstrates certain connections with the doctrine of predestination.
Life and Death by the Book
Authors: Ceballos Manuela 
Published: May 2018

Abstract
The life and works of the beguine Marguerite Porete were transformed by fire. In 1310 Marguerite was burned alive in Paris as the first recorded “mystical heretic” of the French Inquisition. A few years earlier her book, The Mirror of Simple Souls, had also been burned in Valenciennes, with Marguerite as a witness. Her use of fire as a metaphor to describe union with God foreshadows her death. Furthermore, The Mirror’s emphasis on the insufficiency of language to describe the divine echoes Marguerite’s silence during her inquisitorial trial. However, these complaints against language in her book and Marguerite’s own refusal to speak should not be seen as an absolute rejection of text, body, and oral expression as vehicles of divine and human encounter. Instead, they reveal a theory of performance in which life and reading cannot be easily separated into different realms of experience.
MACHINE LEARNING METHODS IN DIGITAL AGRICULTURE: ALGORITHMS AND CASES
Authors: Koshkarov Aleksandr Vasilyevich 
Published: May 2018

Обеспечение продовольственной безопасности является важной задачей многих стран. В условиях роста населения Земли вопросы повышения эффективности сельского хозяйства становятся наиболее актуальными. Фермеры ищут новые способы повышения урожайности, а правительства разных стран разрабатывают новые программы поддержки сельского хозяйства. Это способствует более активному внедрению цифровых технологий в сельское хозяйство, помогая фермерам более эффективно принимать решения, увеличивать урожайность и заботиться об экологии. Центральное место здесь занимает сбор и анализ данных. В области земледелия данные могут собираться из разных источников и содержат в себе полезные закономерности, выявляющие потенциальные проблемы или возможности. Чтобы извлечь пользу из данных, они должны быть проанализированы с помощью алгоритмов машинного обучения. Такие методы точного земледелия позволяют следить за отдельными частями поля, оптимизировать расход воды и химикатов, а также оперативно выявлять проблемы.Цель: обзор алгоритмов машинного обучения, применяемых для анализа данных в сельском хозяйстве.Методология проведения работы: обзор релевантной литературы, опрос фермеров.Результаты: выявлены релевантные алгоритмы машинного обучения для анализа данных в сельском хозяйстве на различных уровнях: анализ почвы (оценка состояния почвы, классификация почвы, прогнозироваие плодородности почвы), прогноз погоды (имитация смены климата, прогноз температуры и осадков) и анализ состояния растительности (идентификация сорняков, классификация растительности, выявление болезни растений, прогнозирование урожайности).Область применения результатов: сельское хозяйство, растениеводство.
Dynamic Distribution of Patients to Medical Facilities in the Aftermath of a Disaster
Authors: Mills Alex F. , Argon Nilay Tanık , Ziya Serhan 
Published: May 2018

In the aftermath of a disaster, emergency responders must transport a large number of patients to medical facilities, using limited transportation resources (such as ambulances). Decisions about where to send the patients are typically made in an ad hoc manner by responders on the scene. Using a Markov decision process formulation, we develop two heuristic policies that use limited information such as mean travel times and congestion levels to determine (a) how to allocate ambulances to patient locations and (b) which medical facility should be the destination for those ambulances. In a simulation study, we incorporate patient survival rates and service times for different types of traumatic injuries, and show that the proposed heuristics can provide substantial improvement in the expected number of survivors compared to the common practice of transporting to the nearest facility, even when the decision maker has only limited up-to-date information about the system state. In particular, a myopic approach that considers only what is best for the next patient to be transported increases the expected number of survivors in almost all scenarios considered. Using a more sophisticated one-step policy improvement approach provides further improvement when the event involves patients who do not deteriorate rapidly, especially when the transportation is not the bottleneck and the casualties are spread over many locations. We demonstrate the effectiveness of the proposed heuristics on a case study of a hypothetical earthquake, where casualty data is generated using computer software developed by the U.S. government. The e-companion is available at https://doi.org/10.1287/opre.2017.1695 .
Into the wild: Pioneers in designing new business models for co-creation
Authors: Degnegaard Stine 
Published: May 2018

Abstract
This study examines a group of business executives’ endeavours of designing new business models in very different public, as well as private, sectors. The common thread between them is that they all have gone ‘into the wild’: leaving the comfort zones of their organizations in order to explore business potential on the outside. They have all taken on challenges that reach far beyond their own organizations’ horizons, crossing sectors and co-creating new business models with external stakeholders in order to address them. When taking on these co-creation challenges, the organizations have fallen short of ready-made methods, processes and steering mechanisms. The questions thus remain: What happens in the wild? And what can we learn from those who went there? The study shows two main findings. First of all, when designing new co-creation business models, organizations encounter similar struggles and possibilities even when dealing with very diverse challenges in different sectors. Thus, insights translate across sectors and challenges. Secondly, a synthesis of lessons learned can be summed up as three main focus areas: the executives are rethinking their business as a whole; they lack tools for organizing for co-creation; and trust-building is a key parameter for success.
Smart-innovative cities and the innovation economy: A qualitative analysis of local approaches to delivering smart urbanism in Australia
Authors: Maalsen Sophia , Burgoyne Sandy , Tomitsch Martin 
Published: May 2018

Abstract
The adoption of smart city initiatives is a key lever to attract and retain new business and talent in local government areas to support the development of the innovation economy in Australia. To identify the ‘state of play’ in the adoption of smart city initiatives within local government areas, we survey state and federal policy associated with ‘smart’ and present a qualitative analysis of four case studies of cities. We then synthesize our findings from this analysis into recommendations for smart city initiatives. The article is structured into three parts. First, we present an overview of the rationale behind the adoption of smart city initiatives in supporting the innovation economy, focusing on challenges and opportunities that have been documented in previous literature. Second, we describe the case studies analysed and the themes that emerged. Third, we discuss the design recommendations arising from this analysis to illustrate how Australian cities and businesses might accelerate the adoption of smart city initiatives in local government areas and the implications more broadly for smart city adoption globally.
Designing interactive fashion shows: Innovating through multisensory simulations
Authors: Lau Kung Wong , Lee Vincie Pui Yuen 
Published: May 2018

Abstract
The tremendous development of stereoscopic 3D visualization and multisensory simulations has been fundamentally changing brand communication, consumer learning, product knowledge and the decision-making process. This research aims to study consumer learning in a designed interactive fashion show platform in order to deepen our understanding of the undiscovered framework. A designed, self-directed interactive platform for consumers to organize their own fashion show is established in this research. The result of this study suggests three major domains for fashion retailing businesses to explore in order to cope with the challenges of the digital age.
Bayesian Inference of Causal Effects for an Ordinal Outcome in Randomized Trials
Authors: Chiba Yasutaka 
Published: May 2018

Abstract
In randomized trials in which two treatment arms are compared with a binary outcome, the causal effect can be identified by assuming that the two treatment arms are exchangeable. In trials with an ordinal outcome, which is categorized as more than two, the causal effect can be identified by assuming that the potential outcomes are independent and that the two treatment arms are exchangeable. In this article, we propose a Bayesian approach to causal inference that does not rely on these two assumptions. To achieve this purpose, we use a randomization-based approach and response type. Then, the likelihood function is derived by physical randomization in which subjects who belong to a response type are randomly assigned to the treatment or control, with no modeling assumption on the outcome. Our approach can derive not only the posterior distribution of the causal effect but also that of the number of subjects in each response type. The proposed approach is illustrated with two examples from randomized clinical trials.