bluuebunny/crossref_metadata_2025_split huggingface dataset:
Gambling patterns and associated risk and protective factors among Finnish young people
Authors: Oksanen Atte , Sirola Anu , Savolainen Iina , Kaakinen Markus 
Published: April 2019

Background and aims: In recent years online gambling has become a potential risk for young people. The purpose of this study was to analyse patterns of gambling activities and their association with behavioural risk factors and protective factors. Data and Method: A demographically balanced sample of Finnish respondents aged 15–25 years ( N = 1200) filled out an online survey in March–April 2017. Principal component analysis was used to reduce the variables on gambling activities to smaller sets of components, and regression analysis was used to analyse whether behavioural risk factors and protective factors were associated with the gambling patterns found. Results: Two main components were found: online- and skill-based competent gambling and chance-based entertainment gambling. Competent gambling had statistically significant associations with a variety of behavioural problems and risks, including psychological distress, lower social support, lower delay of gratification, hazardous drinking, regular drug use, compulsive Internet use, and problem gambling. Entertainment gambling was associated with lower delay gratification, hazardous drinking, and problem gambling. Entertainment gambling had a negative association with compulsive Internet use and a positive association with social support. Conclusions: Online-based competent gambling is a potentially hazardous form of gambling. New forms of online gambling are potential risks for younger generations. Health professionals working with young people should be aware of the role of online gambling and associated activities.
Cultures and spaces of convenience gambling
Authors: Egerer Michael , Marionneau Virve 
Published: April 2019

Background: In many countries, the bulk of gambling takes place in convenience spaces in relatively confined, local markets. Nevertheless, research on gambling locations has so far concentrated on destination gambling in casinos. Aim: This article studies convenience gambling and distinguishes special (e.g., gambling arcades) from everyday convenience gambling spaces (e.g., electronic gambling machines in supermarkets). Rather than geographically or functionally analysing the harm potential of convenience gambling, we approach the issue through cultural theory. Method: We conducted reception analytical group interviews with Finnish and French gamblers. This method is based on focus-group discussions stimulated by six short film clips. Our data consisted of 14 Finnish and 14 French groups, altogether 110 participants. The interviews were analysed thematically on the basis of the types of discourses the participants evoked. Results: The Finnish respondents discussed how their gambling culture was embedded in their everyday lives. They saw it as a harmless pastime if the sums used were small and otherwise unbudgeted. The French informants instead strongly connected gambling with the casino and were suspicious of the easy, cheap availability of convenience gambling. They also differentiated between exceptional and mundane spaces of convenience gambling, which the interviewed Finnish gamblers did not. Conclusions: Social or cultural availability is not only a matter of access; it also influences gamblers after they have entered the gambling venue. Structural characteristics interact with the gambler and the setting, but they are also mediated by the cultural context.
Development and Psychometric Testing of Liver Transplant Therapeutic Adherence Questionnaire in a Triphasic Mixed-Method Study
Authors: Tohidinezhad Fariba , Aliakbarian Mohsen , Abu-Hanna Ameen , Eslami Saeid 
Published: April 2019

Introduction: Due to the high nonadherence rate to posttransplant regimen and medical indications among liver transplant recipients, systematic patient-centered interventions are needed to improve the medium- and long-term graft and patient survival outcomes. Objective: The aim of this study was to develop and test the psychometric properties of Liver Transplant Therapeutic Adherence Questionnaire. Design: A mixed-method instrument design was conducted in 3 phases: (1) initial item collection was generated by inductive content analysis on internationally available resources, (2) item screening was carried out by a 3-member committee and 25 domain experts including nurses and physicians aiming to establish content validity, and (3) data were collected from 247 liver transplant recipients in May 2016 for psychometric testing. Results: A total of 221 knowledge statements were extracted as potential adherence assessment items. The qualitative screening phase resulted in top 35 important items. The second screening phase was performed quantitatively by 25 experts (n = 14 nurses, n = 7 gastroenterologists and hepatologists, and n = 4 transplant surgeons). A total of 16 items were associated with statistically significant content validity ratio values (≥0.37) to be included in the final questionnaire. Exploratory factor analysis revealed a distinct 4-factor structure that was labeled as: daily activities (α = .93), immunization (α = .93), nutrition (α = .92), and major complications (α = .79). Discussion: Our results reveal evidence of acceptable reliability and validity for Liver Transplant Therapeutic Adherence Questionnaire. This instrument makes it possible to measure recipients’ therapeutic adherence in both domains of research and practice.
Endovascular stent graft repair of complete persistent sciatic artery aneurysm with lower limb ischemia: A case report and review of the literature
Authors: Wang Yuewei , Xin Hai , Tan Haofei , Wang Haofu 
Published: April 2019

Background: Persistent sciatic artery is a rare embryological vascular anomaly, with an incidence of 0.01%–0.05%. Up to 60% of persistent sciatic artery patients will develop aneurysms that can subsequently lead to distal embolization and a high risk of limb loss. Method: Here we report a case with acute limb ischemia caused by thrombus in a right persistent sciatic artery aneurysm. The patient underwent endovascular treatment by deploying a 10 × 150 mm stent graft (Viabahn) in the persistent sciatic artery and two self-expanding bare stents (10 × 40 mm, 10 × 60 mm, SMART) in the stent graft to reinforce the radial resistive force. In addition, we conducted a literature review of articles published in PubMed from 2001 to 2018 regarding stent graft repair of complete persistent sciatic artery aneurysms. A total of 13 articles reported 13 patients with complete persistent sciatic artery aneurysms who underwent endovascular stent graft repair. Result: A favorable result was obtained for this patient, and computed tomographic angiography at 6 months of follow-up revealed patent stent graft. Most articles reported favorable results. Conclusion: Favorable results can be achieved with endovascular stent graft repair and anticoagulation therapy for complete persistent sciatic artery aneurysms.
Chronic extensor hallucis longus tendon rupture treated with double-bundle autograft of extensor hallucis capsularis: A case report
Authors: Kurashige Toshinori 
Published: April 2019

The extensor hallucis capsularis is an accessory extensor tendon with varied occurrence. Here, we present the case of a 40-year-old man with chronic extensor hallucis longus tendon rupture treated using extensor hallucis capsularis tendon as a double-bundle autograft. He had dropped a knife proximal to the right hallux metatarsophalangeal joint 4 months ago. Computed tomography revealed the presence of extensor hallucis capsularis, with its width and thickness, and the point of divergence from the extensor hallucis longus tendon. Because direct suturing was considered difficult and the extensor hallucis capsularis tendon was sufficiently wide and long, double-bundle autograft transplantation of extensor hallucis capsularis was performed. At 1-year follow-up examination, the patient retained almost full function of his hallux. To the best of our knowledge, this is the first case to use this technique. Using the extensor hallucis capsularis tendon for grafting should be carefully considered because the variable width and length may limit the graft strength. Level of evidence: IV
Effects and Changes on Voice After Rhinoplasty: A Long-Term Report
Authors: Guarro Giuseppe , Brunelli Francesco , Rasile Barbara , Alfano Carmine 
Published: April 2019

Introduction: Vocal changes after rhinoplasty have been poorly investigated, although this surgical procedure is nowadays one of the most requested. The production of voice largely depends on the anatomy and the size of the pyramid and the nasal cavity. The authors report 51 cases of both closed and open rhinoplasty and propose a 2-year report to analyze potential effective changes on voice. Materials and Methods: Fifty-one patients were enrolled and evaluated from September of 2012 to January of 2018. All patients were studied before and 2 years after surgery. Vocal changes were assessed with an objective and a subjective evaluation. The first one allowed to perform the measurement of the intensity and frequency of vowel sound (“a”) and nasal consonant sounds (“n” and “m”). For the subjective evaluation, our modified version of Voice Handicap Index Score allowed us to evaluate every single characteristic of the personal perception of voice. Results: The objective evaluation showed an increased frequency of production of the consonant sounds in 62% of cases and an increased frequency of production of the vowel sound in 68% of cases. The subjective evaluation allowed us to notice significant changes after surgery ( P = .044). No significant differences were noticed between closed and open approach. Conclusion: Reduction rhinoplasty technique proved to induce several alterations on vocal pattern. The surgeon should always inform patients about the potential effects on the voice, particularly when such changes may produce influences on the working life.
Anatomic femoral tunnel creation during anterior cruciate ligament reconstruction using curved dilator system
Authors: Lee Kee Byoung , Kwon Bong Cheol , Kim Joong Il , Lee Hyung-Min , Lee Joon Kyu 
Published: April 2019

Purpose: Recently, tunnel placements in anatomic positions have been emphasized for successful restoration of knee function after anterior cruciate ligament (ACL) reconstruction. The anteromedial portal technique is considered to be more favorable than the transtibial technique for anatomic femoral tunnel placements; however, it has some technical disadvantages. To minimize these disadvantages, the authors developed the curved dilator system (CDS). The purpose of this study was to evaluate the femoral tunnel position, length, and intraoperative complications with CDS. Methods: Sixty-two consecutive patients who underwent ACL reconstruction with CDS were subjects of this study. The femoral tunnel was created using a 4.5 mm-diameter curved guide trocar and was widened in a step-by-step manner, increasing by 1 mm dilator diameter to match the graft with the knee flexed to slightly over 90°. Femoral tunnel positions were evaluated by the quadrant method from postoperative computed tomographic images. Femoral tunnel length was measured using the curved depth gauge during surgery. Complications such as posterior wall blowout and cartilage damage were checked intraoperatively. Peroneal nerve injury was observed during the hospital stay. Results: Femoral tunnel position was 32.7% ± 5.4% and 39.1% ± 5.9% in the superior-inferior and anterior-posterior positions, respectively. Femoral tunnel length was 39.2 ± 4.1 mm. Damage to medial femoral condyle cartilage, posterior wall blowout, and peroneal nerve injury did not occur in any case. Conclusion: ACL reconstruction with CDS resulted in anatomic positioning of the femoral tunnel and sufficient femoral tunnel length without intraoperative complications.
Epidemiology of Elbow Ulnar Collateral Ligament Injuries in Throwing Versus Contact Athletes of the National Collegiate Athletic Association: Analysis of the 2009-2010 to 2013-2014 Seasons
Authors: Li Neill Y. , Goodman Avi D. , Lemme Nicholas J. , Owens Brett D. 
Published: April 2019

Background: The management and outcomes of elbow ulnar collateral ligament (UCL) injuries in throwing athletes have been well investigated. However, less is known regarding the management, severity, and outcomes of such injuries in contact athletes. Purpose: To compare the incidence, severity, and outcomes of elbow UCL injuries between throwing and contact athletes in collegiate sports. Study Design: Descriptive epidemiology study. Methods: Elbow UCL injuries were queried from the National Collegiate Athletic Association (NCAA) Injury Surveillance Program between the seasons of 2009-2010 and 2013-2014 in 25 varsity sports. The rates and distribution of injuries by mechanism, participation restriction time, and outcomes (eg, season-ending injury, surgery) were examined. A severe injury was defined as loss of ≥21 days from participation, a season-ending injury, or requiring a surgical intervention. The injury frequency, incidence per 10,000 athlete-exposures (AEs), and injury proportion ratio comparing throwing and contact athletes were calculated with 95% CIs. Results: Over the course of 5 seasons, 109 UCL injuries were recorded, for an overall injury rate of 0.29 per 10,000 AEs. Of these injuries, 83 (76.1%) were a result of contact and 26 (23.9%) from throwing. Men’s wrestling (1.78 per 10,000 AEs) and men’s baseball (1.12 per 10,000 AEs) sustained the highest injury rates. A larger proportion of throwing (n = 8; 36.4%) compared with contact (n = –7; 9.1%) ( P < 0.01) injuries results in >21 days of time loss. Additionally, more throwing-related UCL injuries required surgery (n = 2; 11.1%) compared with contact-related injuries (n = 1; 1.3%) ( P < 0.01). As a result, throwing athletes demonstrated a significantly higher proportion of severe injuries than contact athletes (injury proportion ratio, 4.62 [95% CI, 1.72-12.40]). Conclusion: The evaluation of athletes in 25 collegiate varsity sports across 5 seasons found over 3 times more elbow UCL injuries in contact versus throwing athletes. However, the number of severe injuries in throwing athletes was significantly higher than in contact athletes. These findings demonstrate that although elbow UCL injuries are prone to occur in both contact and throwing athletes, their prevention, management, and outcomes must be framed on a sport-by-sport basis.
Analysis of finishing forces and surface finish during magnetorheological abrasive flow finishing of asymmetric workpieces
Authors: Jayant  , Jain V. K. 
Published: April 2019

Magnetorheological abrasive flow finishing (MRAFF) is an advanced hybrid process for producing ultrafine finished surfaces. Such surfaces reduce frictional forces and thereby minimize wear and tear to increase functional lifetime of the components. In the present research work, a model has been developed for simulating the results of MRAFF process. First, magnetic field is simulated and then a detailed study on the rheology of the magnetorheological polishing (MRP) fluid is conducted to develop a viscosity model for the flow of non-Newtonian shear thinning fluid. To calculate the forces acting in the process of material removal, the flow of MRP fluid around an asymmetric workpiece (knee joint) in a spatially varying magnetic field is simulated. Finishing forces exerted by the abrasive particles on the workpiece surface are analysed to develop a model for predicting surface roughness. A methodology has been proposed to evolve a variable correction factor to determine active abrasive particles at different locations on the workpiece surface for accurate simulation of surface finish operation. It is found that the magnetic field greatly influences the process performance by governing the viscosity of the MRP fluid and the distribution of the abrasive particles in the medium. During finishing of an asymmetric workpiece, the surface finish obtained at different locations on the workpiece surface is different. The developed model is capable to predict final surface finish within the acceptable accuracy when compared with the experimental results.
Proteomic evidence of specific IGKV1-8 association with cystic lung light chain deposition disease
Authors: Camus Mylène , Hirschi Sandrine , Prevot Grégoire , Chenard Marie-Pierre , Mal Hervé , Stern Marc , Reynaud-Gaubert Martine , Gilhodes Julia , Burlet-Schiltz Odile , Brousset Pierre , Colombat Magali 
Published: April 2019

Abstract
We previously reported a new form of light chain deposition disease (LCDD) presenting as diffuse cystic lung disorder that differs from the usual systemic form with respect to patient age, the male/female ratio, the involved organs, and the hematologic characteristics. We also demonstrated that the light chains were produced by an intrapulmonary B-cell clone and that this clone shared a stereotyped antigen receptor IGHV4-34/IGKV1. However, we only analyzed 3 patients. We conducted a retrospective study including lung tissue samples from 24 patients with pulmonary LCDD (pLCDD) matched with samples from 13 patients with pulmonary κ light chain amyloidosis (pAL amyloidosis) used as controls. Mass spectrometry–based proteomics identified immunoglobulin κ peptides as the main protein component of the tissue deposits in all patients. Interestingly, in pLCDD, IGKV1 was the most common κ family detected (86.4%), and IGKV1-8 was overrepresented compared with pAL amyloidosis (75% vs 11.1%, P = .0033). Furthermore, IGKV1-8 was predominantly associated with a diffuse cystic pattern (94%) in pLCDD. In conclusion, the high frequency of IGKV1-8 usage in cystic pLCDD constitutes an additional feature arguing for a specific entity distinct from the systemic form that preferentially uses IGKV4-1.
MicroRNA-155 controls vincristine sensitivity and predicts superior clinical outcome in diffuse large B-cell lymphoma
Authors: Due Hanne , Schönherz Anna Amanda , Ryø Laura , Primo Maria Nascimento , Jespersen Ditte Starberg , Thomsen Emil Aagaard , Roug Anne Stidholt , Xiao Min , Tan Xiaohong , Pang Yuyang , Young Ken H. , Bøgsted Martin , Mikkelsen Jacob Giehm , Dybkær Karen 
Published: April 2019

Abstract
A major clinical challenge of diffuse large B-cell lymphoma (DLBCL) is that up to 40% of patients have refractory disease or relapse after initial response to therapy as a result of drug-specific molecular resistance. The purpose of the present study was to investigate microRNA (miRNA) involvement in vincristine resistance in DLBCL, which was pursued by functional in vitro analysis in DLBCL cell lines and by outcome analysis of patients with DLBCL treated with rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP). Differential miRNA expression analysis identified miR-155 as highly expressed in vincristine-sensitive DLBCL cell lines compared with resistant ones. Ectopic upregulation of miR-155 sensitized germinal-center B-cell-like (GCB)–DLBCL cell lines to vincristine, and consistently, reduction and knockout of miR-155 induced vincristine resistance, documenting that miR-155 functionally induces vincristine sensitivity. Target gene analysis identified miR-155 as inversely correlated with Wee1, supporting Wee1 as a target of miR-155 in DLBCL. Chemical inhibition of Wee1 sensitized GCB cells to vincristine, suggesting that miR-155 controls vincristine response through Wee1. Outcome analysis in clinical cohorts of DLBCL revealed that high miR-155 expression level was significantly associated with superior survival for R-CHOP-treated patients of the GCB subclass, independent of international prognostic index, challenging the commonly accepted perception of miR-155 as an oncomiR. However, miR-155 did not provide prognostic information when analyzing the entire DLBCL cohort or activated B-cell–like classified patients. In conclusion, we experimentally confirmed a direct link between high miR-155 expression and vincristine sensitivity in DLBCL and documented an improved clinical outcome of GCB-classified patients with high miR-155 expression level.
Sonographic follow-up after endoscopic carpal tunnel release for severe carpal tunnel syndrome: a one-year neuroanatomical prospective observational study
Authors: Li Miao , Jiang Jue , Zhou Qi , Zhang Chen 
Published: April 2019

AbstractBackgroundEndoscopic carpal tunnel release (ECTR) has been gradually adopted for the treatment of severe carpal tunnel syndrome (CTS). However, perioperative assessment of neuroanatomical parameters of median nerve, which are important determinant of median nerve recovery, has rarely been reported. This one-year prospective study aimed to investigate the natural history of the neuroanatomical morphology of the median nerve after ECTR in severe CTS patients by high-frequency ultrasonography and assess the ability of neuroanatomical measures to quantify morphological recovery of the median nerve after ECTR.MethodsThis study recruited 31 patients (44 wrists) with a definitive diagnosis of severe CTS and underwent ECTR operation. The edema length (EL) of median nerve from the inlet of the carpal tunnel to the proximal wrist was detected on long axis imaging plane and the anteroposterior diameter (D) and cross-sectional area (CSA) at the inlet of the carpal tunnel on short axis imaging plane were detected by high frequency ultrasound. All these metrics were detected at 3 days before surgery and at the 2nd week, 4th week, 3rd month, 6th month and 12th month after surgery separately.ResultsThere was no significant difference of each parameter between the 2-week postoperative (1.914 ± 0.598 cm in EL, 0.258 ± 0.039 cm in D and 0.138 ± 0.015 cm2in CSA) and 3-days preoperative time points (P-EL =0.250;P-D = 0.125;P-CSA =0.712). From the fourth week to the third month after surgery, the parameters quickly improved. The EL (0.715 ± 0.209 cm), D (0.225 ± 0.017 cm) and CSA (0.117 ± 0.012 cm2) at the 3- month postoperative time points were more reduced than at the fourth week after surgery (P-EL < 0.001;P-D = 0.038;P-CSA =0.014). Thereafter, the neurological anatomy parameters recovered slowly. By the 12-month postoperative time points, the three parameters were neuroanatomically close to normal. Compared to the control group in D (0.213 ± 0.005 cm), there was no difference at the 12-month time point (0.214 ± 0.009 cm,P = 0.939). However, the difference in EL (0.098 ± 0.030 cm vs. 0.016 ± 0.011 cm) and CSA (0.103 ± 0.008 cm2vs. 0.073 ± 0.005 cm2) between patients and healthy volunteers at the 12-month time point still existed (P-EL < 0.001;P-CSA < 0.001).ConclusionsNeuroanatomical parameters were gradually improved after ECTR surgery. The best time for US follow up is at 3-month postoperative time point for patients who do not show clinical improvement, since at this time the change is the greatest for most CTS patients. This study has been registered in Chinese Clinical Trial Registry: ChiCTR-ROC-17014068 (retrospectively registered 20-12-2017).