bluuebunny/crossref_metadata_2025_split huggingface dataset:
Why Is the Healing of Emotional Problems So Difficult?
Authors: Friesel Hillel Zvi 
Published: May 2019

Background This article deals with the difficulties involved in the healing of emotional problems. It focuses on the homeopathic treatment combined with other therapeutic approaches.
Findings In working with emotional problems, homeopathy focuses mainly on the action of the homeopathic medicine. Arguably, it over-relies on the healing power of the medicine and gives less attention to the importance of working dynamically with the patient's emotional problems. This article suggests a more balanced approach that combines between these two facets of the healing process, giving more weight to the role of potencies.
Conclusion Emotional healing becomes more plausible when the patient's inner strength attains the level of strength of the disturbance, represented by “level of potency”, which allows the patient to cope with his/her disturbance more successfully.
Findings in Stillbirths Associated with Placental Disease
Authors: Gibbins Karen J. , Pinar Halit , Reddy Uma M. , Saade George R. , Goldenberg Robert L. , Dudley Donald J. , Drews-Botsch Carolyn , Freedman Alexa Ann , Daniels Lauren M. , Parker Corette B. , Thorsten Vanessa , Bukowski Radek , Silver Robert M. 
Published: May 2019

Objective Placental disease is a leading cause of stillbirth. Our purpose was to characterize stillbirths associated with placental disease.
Study Design The Stillbirth Collaborative Research Network conducted a prospective, case–control study of stillbirths and live births from 2006 to 2008. This analysis includes 512 stillbirths with cause of death assignment and a comparison group of live births. We compared exposures between women with stillbirth due to placental disease and those due to other causes as well as between women with term (≥ 37 weeks) stillbirth due to placental disease and term live births.
Results A total of 121 (23.6%) out of 512 stillbirths had a probable or possible cause of death due to placental disease by Initial Causes of Fetal Death. Characteristics were similar between stillbirths due to placental disease and other stillbirths. When comparing term live births to stillbirths due to placental disease, women with non-Hispanic black race, Hispanic ethnicity, lack of insurance, or who were born outside of the United States had higher odds of stillbirth due to placental disease. Nulliparity and antenatal bleeding also increased risk of stillbirth due to placental disease.
Conclusion Multiple discrete exposures were associated with stillbirth caused by placental disease. The relationship between these factors and utility of surveillance warrants further study.
Surgical Management of Lower Extremity Lymphedema: A Comprehensive Review
Authors: Ciudad Pedro , Sabbagh M. Diya , Agko Mouchammed , Huang Tony C.T. , Manrique Oscar J. , L. Carmen Román , Reynaga Cesar , Delgado Ricardo , Maruccia Michele , Chen Hung-Chi 
Published: May 2019

AbstractLymphedema refers to the accumulation of protein-rich fluid in the interstitial spaces. This can occur secondary to congenital malformation of the lymphatic channels or nodes or as a result of an insult that damages appropriately formed channels and nodes. Stagnant, protein-rich lymph initiates an inflammatory response that leads to adipocyte proliferation, fibrous tissue deposition, and increased susceptibility to infections. The end result is permanent disfigurement and dermal changes. Early and accurate diagnosis is essential, since lymphedema is a chronic and progressive problem. When lymphedema affects the lower extremity, it is important to manage it in a way that preserves function and mobility. Early diagnosis also allows for a proactive rather than reactive approach to treatment and utilization of novel physiologic procedures, such as lymphovenous anastomosis and vascularized lymph node transfer. Such interventions slow down disease progression and reduce morbidity by allowing the surgeon to salvage the remaining functional lymphatic channels. When physiologic procedures fail or when faced with a delayed presentation, the addition of excisional procedures can provide a more comprehensive treatment of this debilitating disease. The aim of this article is to review the most current concepts in the surgical management of lower extremity lymphedema.
Autologous Breast Reconstruction Skin Paddle Designs: Classification and Aesthetic Outcomes
Authors: Pestana Ivo , Walker Nicholas 
Published: May 2019

Objective Present study was conducted to identify common mastectomy patterns and autologous skin paddle designs, to identify patient characteristics that influence these patterns, and assess aesthetic outcomes associated with each pattern.
Methods Autologous breast reconstructions over 5 years were reviewed. Mastectomy type and resultant skin paddle were categorized into four mastectomy type/skin paddle design groups based on the amount of native “Skin Spared” after mastectomy and the resultant flap skin paddle designed. Groups were designated as skin-sparing mastectomy 1 (SS1)/large elliptical skin paddle, skin-sparing mastectomy 2 (SS2)/small elliptical skin paddle, skin-sparing mastectomy 3 (SS3)/areola skin paddle, and skin-sparing mastectomy 4 (nipple-sparing mastectomy, SS4)/no skin paddle. Surveys were performed to validate the classification system and critique aesthetic outcomes.
Results A total of 89 autologous breast reconstructions were included. Radiotherapy was used in 45.6% of SS1 patients versus 29.2% in SS2 and 12.5% in SS3/SS4. Mean body mass index (BMI) was 30 in SS1/SS2 and 26 in SS3/SS4 mastectomy types (p = 0.045). Delayed reconstruction was performed in 96.5% SS1 versus 62.5% in SS2 and only 25% of SS3/SS4 (p < 0.0001). Physicians and Non-MD personnel correctly categorized 85.8 and 76.1% of skin paddle designs, respectively. Over 75% of those surveyed rated the reconstruction aesthetic outcome as “good-excellent” regardless of the pattern group.
Conclusions Patients in SS1/SS2 groups had a higher incidence of radiotherapy, delayed reconstruction, and higher BMI compared with the SS3/SS4 groups. The classification system is recognizable and may provide improved patient education and communication between healthcare providers. All mastectomy type/skin paddle designs received high aesthetic ratings.
Total Knee Arthroplasty: Fitness, Heart Disease Risk, and Quality of Life
Authors: Casazza Gretchen A. , Lum Zachary C. , Giordani Mauro , Meehan John P. 
Published: May 2019

AbstractTotal knee arthroplasty (TKA) may decrease coronary heart disease (CHD) risk in patients with advanced osteoarthritis by reducing pain and allowing for a more active lifestyle. We examined cardiovascular fitness, CHD risk factors, and quality of life in patients for 1 year after TKA compared with matched controls who did not undergo surgery. A total of 14 patients, 7 surgery patients and 7 matched controls, were tested for measurements of body composition, knee range of motion, resting blood pressure, strength testing, a maximal exercise test, quality-of-life questionnaires (Medical Outcomes Study Short Form-36 and Knee Osteoarthritis Outcome Score [KOOS]), and activity monitoring, fasting blood glucose, and lipids at 0, 3, 6, and 12 months after surgery or baseline testing. Comparison between the two groups was analyzed. Twelve months after surgery, patients with TKA had significantly (p < 0.05) lower pain scores, increased fat free mass, lower resting mean arterial pressure, and improved scores on the KOOS for pain, symptoms, activities of daily living, and quality of life. Initially, total cholesterol, high-density lipoprotein cholesterol, triglycerides, and body fat percentage were reduced in the TKA group but returned to baseline at 12 months. The results of this study indicate that there are immediate and long-term improvements in pain and quality of life in patients with TKA, but physical function, exercise capacity, leg strength, and some lipid profiles may take longer than 12 months to improve. This is a level II, prospective, Therapeutic study, comparative study.
Study of Gilbert's Syndrome-Associated UGT1A1 Polymorphism in Jaundiced Neonates of ABO Incompatibility Hemolysis Disease
Authors: Yu Yingfang , Du Lizhong , Chen An , Chen Lihua 
Published: May 2019

Abstract
Objective This study aimed to assess the probable relationship between icter in neonates with ABO incompatibility hemolysis and UGT1A1 gene polymorphism.
Study Design There were 65 ABO hemolytic disease of the newborn (HDN) neonates of full term in the study group and 82 non-ABO HDN neonates of full term in the compared group. We tested the UGT1A1 gene mutation of neonates of ABO HDN and non-ABO HDN. We compared the incidence of hyperbilirubinemia between neonates with and without UGT1A1 mutations in the ABO HDN and non-ABO HDN, to determine the relationship between icter in neonates with ABO HDN and UGT1A1 gene polymorphism. SPSS 13.0 were used to analyze those two groups' data.
Results There was statistically significant difference of the serum bilirubin level between the Gly71Arg homozygous and no mutation group in the ABO HDN patients (p < 0.05). When hyperbilirubinemia was defined as serum bilirubin concentration >342 μmol/L, the incidence of hyperbilirubinemia between patients of UGT1A1 and non-UGT1A1 mutations in the ABO HDN group was significantly different (p < 0.05). But in the non-ABO HDN group, no significant difference was found.
Conclusion Individuals with Gly71Arg homozygous contributed to their hyperbilirubinemia in ABO HDN patients.
Risk Factors for 30-Day Mortality in Neonatal Gram-Negative Bacilli Sepsis
Authors: Thatrimontrichai Anucha , Premprat Nutchana , Janjindamai Waricha , Dissaneevate Supaporn , Maneenil Gunlawadee 
Published: May 2019

Objective Multidrug-resistant gram-negative bacilli (MDR-GNB) have emerged globally as a serious threat and with a high case fatality rate (CFR).
Study Design We performed a case–control study in a Thai neonatal intensive care unit to identify the risk factors for 30-day CFR of GNB sepsis between 1991 and 2017. The CFR was analyzed by Cox's proportional hazards model.
Results For 27 years, the percentage of MDR-GNB from GNB sepsis was 66% (169/257). The medians (interquartile ranges) of gestational age and birth weight of the neonates with GNB sepsis were 33 (29–38) weeks and 1,817 (1,100–2,800) grams, respectively. The 30-day CFRs of the neonates with MDR-GNB and non-MDR-GNB sepsis were 33% (56/169) and 20% (18/88), respectively, (hazard ratio [HR] = 1.74; 95% confidence interval [CI]: 1.03–2.97; p = 0.04). Using Cox's proportional hazards model, nonsurvivors in GNB sepsis were more likely to have septic shock (adjusted HR [aHR] = 6.67; 95% CI: 3.28–13.57; p < 0.001) or no microbiological cure (aHR = 10.65; 95% CI: 4.98–22.76; p < 0.001) than survivors.
Conclusion Neonates suspected of sepsis with septic shock need broad-spectrum empirical antimicrobial therapy until the second successive negative culture, especially in high MDR areas.
Useful Platelet Indices for the Diagnosis and Follow-Up of Patent Ductus Arteriosus
Authors: Guler Kazanci Elif , Buyuktiryaki Mehmet , Unsal Handan , Tayman Cuneyt 
Published: May 2019

Objective The aim of this study was to assess the utility of early postnatal platelet indices in the prediction of hemodynamically significant patent ductus arteriosus (hsPDA) and its response to pharmacological treatment in preterm infants.
Study Design The medical records of 971 infants with gestational age < 30 weeks and birth weight < 1,500 g were analyzed retrospectively. Infants with hsPDA comprised the study group and those without hsPDA comprised the control group. Complete blood count results were recorded, and red cell distribution width-to-platelet ratio (RPR) and platelet mass were calculated.
Results A total of 481 infants, 169 in the hsPDA group and 312 in the control group, were included. In terms of platelet indices, the hsPDA group showed significantly lower mean platelet volume (MPV) and platelet mass, whereas RPR was significantly higher (p < 0.05, respectively). Multiple logistic regression analysis showed that RDS (relative ratio [RR]: 2.39; 95% confidence interval [CI]: 1.45–3.93; p < 0.001), MPV < 7.85 (RR: 3.71; 95% CI: 2.29–6.01; p < 0.001), and RPR > 0.070 (RR: 5.33; 95% CI: 3.28–8.65; p < 0.001) were independent risk factors for hsPDA.
Conclusion Low MPV and platelet mass and high RPR in the first hours of life are risk factors for hsPDA and hsPDA refractive to pharmacological treatment with ibuprofen in preterm infants.
Spatial patterning among savanna trees in high-resolution, spatially extensive data
Authors: Staver A. Carla , Asner Gregory P. , Rodriguez-Iturbe Ignacio , Levin Simon A. , Smit Izak P.J. 
Published: May 2019

Significance
Understanding how environmental variation shapes vegetation distributions is crucial for predicting biosphere responses to global change. Savannas represent a major challenge, and repeated efforts have failed to constrain variation in savanna vegetation structure to a useful degree. Here, we find that trees cluster in savannas and that their clustering is governed by power laws, with parameters and geometries that are invariant to environment. This explains why savannas have resisted mechanistic characterization and offers a possible tool for constraining variability in vegetation structure.
Hidden interactions in financial markets
Authors: Stavroglou Stavros K. , Pantelous Athanasios A. , Stanley H. Eugene , Zuev Konstantin M. 
Published: May 2019

Significance
The importance of understanding the structure of financial markets has been progressively coming to a head in public discourse. With the rise and prevalence of big datasets, it is a crucial time for academics to study the interdependency outside conventional analysis. Thus, the methodology proposed in this paper does not only allow distinction between positive and negative interdependence, but additionally identifies a yet unexplored form of interaction we coin as “dark causality.” We benchmark this method on asset pairs and on a network of sovereign credit default swaps, where the dominant form of interaction is that of dark causality. Our results are relevant to finance practitioners who, by virtue of their profession, tend to engage on a regular basis with retail investors.
Inhibition of β-catenin/B cell lymphoma 9 protein−protein interaction using α-helix–mimicking sulfono-γ-AApeptide inhibitors
Authors: Sang Peng , Zhang Min , Shi Yan , Li Chunpu , Abdulkadir Sami , Li Qi , Ji Haitao , Cai Jianfeng 
Published: May 2019

Significance
The design of cell-penetrating long peptidomimetic scaffolds for interacting with large protein binding interfaces is challenging because they involve various necessary functional groups. Here we report the first series of helical sulfono-γ-AApeptides that disrupt protein–protein interactions. Specifically, we discovered that these helical mimetics can structurally and functionally mimic the B Cell Lymphoma 9 (BCL9) helix and disrupt cancer-related β-catenin/BCL9 protein–protein interaction in cells with excellent potency and specificity. Enzymatic stability studies demonstrate the remarkable stability of the helical sulfono-γ-AApeptides, augmenting their biological potential. This strategy could be adapted to target a myriad of other disease-related protein–protein interactions.
Unsupervised determination of protein crystal structures
Authors: Ufimtsev Ivan S. , Levitt Michael 
Published: May 2019

Significance
Solving crystal structures of large biological macromolecules in the absence of experimental phase information, especially at low resolution, is a tedious problem prone to mistakes and overfitting. Due to errors stemming from poorly interpretable parts of the electron density map, human experience and intuition are imperative for building a correct atomistic model. For this reason, tools for automatic structure determination used nowadays require constant human supervision. Here we present a method that can overcome the difficulties; it greatly reduces or even eliminates human involvement in the solution process by working with ensembles of possible solutions. This approach can find solution of a higher quality than can humans and can solve difficult cases not amenable to other methods.
Aneuploidy drives lethal progression in prostate cancer
Authors: Stopsack Konrad H. , Whittaker Charles A. , Gerke Travis A. , Loda Massimo , Kantoff Philip W. , Mucci Lorelei A. , Amon Angelika 
Published: May 2019

Significance
Aneuploidy is usually quantified by measuring intracellular DNA content or chromosome structure and number. We show that the number of altered chromosome arms can be estimated from transcriptome profiling, which allows for assessing aneuploidy within repositories of archival, formalin-fixed, paraffin-embedded tumors. While aneuploidy impedes proliferation in primary cells, we show that it is a feature of aggressiveness in primary prostate cancers that are more likely to become lethal. Our data suggest that losses or gains of entire chromosome arms confers aggressiveness beyond affecting copy numbers of tumor suppressors or oncogenes on those arms. Beyond helping understand the etiology of aggressive prostate cancer, we propose that extent of aneuploidy could also be employed clinically to inform risk stratification and treatment.
Effects of the relationships between forms within and across paradigms on lexical processing and
representation
Authors: Parker Jeff 
Published: May 2019

Abstract
The frequency and distribution of forms within a lexeme’s paradigm affect how quickly forms are accessed (e.g.,
Kostić, 1991; Milin, Filipović Đurđević, &
Moscoso del Prado Martín, 2009; Moscoso del Prado Martı́n, Kostić, & Baayen,
2004). The distribution of forms across paradigms, in contrast, has received little experimental attention. Theoretical
studies investigate the distribution of forms across paradigms because forms vary in how predictive they are of other (unknown)
forms. Such investigations have uncovered typological tendencies (e.g., Ackerman & Malouf,
2013; Stump & Finkel, 2013) and contribute to explanations of
language-specific phenomena (e.g., Sims, 2015; Parker & Sims, To appear). The intersection of these research approaches raises questions about how the
distribution of forms within and across paradigms affects lexical access and representation. Based on forms of
Russian nouns representing two morphosyntactic property sets and lexemes from three inflection classes, it is shown that speakers
are sensitive to differences in form and morphosyntactic property set in a visual lexical decision task. In a priming task,
nominative forms prime locative forms better than vice versa regardless of suffix, despite differences between the same forms in
the lexical decision task. These results suggest that speakers make generalizations about forms across classes, including at the
level of word forms and morphosyntactic property sets.
Spring‐mass characteristics during human locomotion: Running experience and physiological considerations of blood lactate accumulation
Authors: Bitchell C. L. , McCarthy‐Ryan M. , Goom T. , Moore I. S. 
Published: May 2019

AbstractThe aim of this study was to examine how running experience affects leg stiffness (Kleg) and spring‐mass characteristics during running stages associated with the onset of blood lactate accumulation (OBLA). Seven trained (66.9 ± 4.8 kg; 182 ± 4.0 cm; 23.1 ± 3.1 years) and 13 untrained (78.5 ± 7.6 kg; 182 ± 3.0 cm; 20.3 ± 1.5 years) runners completed an incremental treadmill run. Running velocity was increased by 1 km.h−1 every four minutes and blood lactate samples were taken at every stage, in addition to a 10 s video recording using ‘Runmatic’. Once 4 mmol L−1 (OBLA; the second lactate turn point) had been reached one more stage was completed. Spring‐mass characteristics across groups and at pre‐OBLA, OBLA and post‐OBLA were compared. The velocity at OBLA was higher for the trained runners compared to the untrained runners (18 ± 0.7 vs 11 ± 1.3 km.h−1, p < 0.001). Kleg was similar between untrained and trained runners across each stage (15.8 ± 0.3 vs 14.3 ± 0.3 kN.m) and did not change between stages, yet spring‐mass characteristics differed between groups. Vertical stiffness increased in the trained runners from pre‐OBLA to post‐OBLA (45.5 ± 3.35–51.9 ± 3.61 kN−1), but not in untrained runners (35.0 ± 5.2–39.6 ± 5.7 kN−1). Kleg was strongly related to Fpeak for trained runners only (r = 0.79; untrained runners, r = 0.34). Kleg was unaffected by physiological training status and was maintained across all OBLA stages. Trained runners appear to have optimised their spring‐mass system in a homogenous manner, whilst less consistent spring‐mass characteristics were observed in untrained runners.
Comprehensive evaluation of deep learning architectures for prediction of DNA/RNA sequence binding specificities
Authors: Trabelsi Ameni , Chaabane Mohamed , Ben-Hur Asa 
Published: May 2019

Abstract

Motivation
Deep learning architectures have recently demonstrated their power in predicting DNA- and RNA-binding specificity. Existing methods fall into three classes: Some are based on convolutional neural networks (CNNs), others use recurrent neural networks (RNNs) and others rely on hybrid architectures combining CNNs and RNNs. However, based on existing studies the relative merit of the various architectures remains unclear.

Results
In this study we present a systematic exploration of deep learning architectures for predicting DNA- and RNA-binding specificity. For this purpose, we present deepRAM, an end-to-end deep learning tool that provides an implementation of a wide selection of architectures; its fully automatic model selection procedure allows us to perform a fair and unbiased comparison of deep learning architectures. We find that deeper more complex architectures provide a clear advantage with sufficient training data, and that hybrid CNN/RNN architectures outperform other methods in terms of accuracy. Our work provides guidelines that can assist the practitioner in choosing an appropriate network architecture, and provides insight on the difference between the models learned by convolutional and recurrent networks. In particular, we find that although recurrent networks improve model accuracy, this comes at the expense of a loss in the interpretability of the features learned by the model.

Availability and implementation
The source code for deepRAM is available at https://github.com/MedChaabane/deepRAM.

Supplementary information
Supplementary data are available at Bioinformatics online.
Reconstructing signaling pathways using regular language constrained paths
Authors: Wagner Mitchell J , Pratapa Aditya , Murali T M 
Published: May 2019

Abstract

Motivation
High-quality curation of the proteins and interactions in signaling pathways is slow and painstaking. As a result, many experimentally detected interactions are not annotated to any pathways. A natural question that arises is whether or not it is possible to automatically leverage existing pathway annotations to identify new interactions for inclusion in a given pathway.

Results
We present RegLinker, an algorithm that achieves this purpose by computing multiple short paths from pathway receptors to transcription factors within a background interaction network. The key idea underlying RegLinker is the use of regular language constraints to control the number of non-pathway interactions that are present in the computed paths. We systematically evaluate RegLinker and five alternative approaches against a comprehensive set of 15 signaling pathways and demonstrate that RegLinker recovers withheld pathway proteins and interactions with the best precision and recall. We used RegLinker to propose new extensions to the pathways. We discuss the literature that supports the inclusion of these proteins in the pathways. These results show the broad potential of automated analysis to attenuate difficulties of traditional manual inquiry.

Availability and implementation
https://github.com/Murali-group/RegLinker.

Supplementary information
Supplementary data are available at Bioinformatics online.