bluuebunny/crossref_metadata_2025_split huggingface dataset:
Combined effects of DDE and hyperlipidic diet on metallothionein expression and synthesis in rat tissues
Authors: Migliaccio Vincenzo , Lionetti Lillà , Putti Rosalba , Sica Raffaella , Scudiero Rosaria 
Published: December 2018

AbstractMetallothionein is well known for its detoxificant and anti‐oxidant properties and has been shown to be effective to prevent hydroxyl radical‐generated DNA degradation. The purpose of this investigation was to analyze the combined effect of two factors promoting cellular oxidative‐stress, that is, the administration of the pesticide dichloro–diphenyl–dichloroethylene (DDE) and a high fat diet, on metallothionein expression and synthesis in rat liver and kidney. DDE is the main metabolite of dichloro–diphenyl–trichloroethane (DDT), and is commonly found in the food chain and in all tissues of living organisms, carried by the fats. Male Wistar rats were fed with a standard (N) or a high fat (HF) diet and exposed to DDE (10 mg/kg body mass, N + DDE and HF + DDE groups) or vehicle (corn oil, N, and HF groups) via gavage every day for 28 days. Tissues histology was determined by light microscopy analysis; differences in metallothionein gene expression and synthesis by real‐time PCR and western blot, respectively. Finally, protein cellular localization was established by immunocytochemistry. The results showed a different involvement of metallothionein in defending tissues from HF‐ and DDE‐induced oxidative stress, suggesting that hepatic and renal cells use different strategies against pro‐oxidant species. In both cell types a marked increase in the metallothionein content was observed in the nucleus, with a concomitant drop of the cytoplasmatic protein, either under HF‐ and DDE‐stress conditions; however, no synergistic or additive effects were observed between the action of fats and pesticide. These findings reinforce the role of metallothionein in protecting DNA from oxidative damage.
Accreted ice mass ratio (k‐factor) for rotating wind turbine blade profile and circular cylinder
Authors: Sokolov Pavlo , Jin Jia Yi , Virk Muhammad S. 
Published: December 2018

AbstractThis paper describes a study to investigate the relation between ice accretion on a rotating wind turbine blade profile (airfoil) and a reference collector (circular cylinder). This relation, known as “k‐factor,” describes the ratio of accreted ice mass on a reference collector and wind turbine blade profile. Analyses are carried out by performing a series of multiphase numerical simulations and ISO 12494‐based analytical calculations. The results show that k‐factor is not equal to constant 20, contrary to currently postulated assumption by VTT and can vary to a significant degree depending on a number of different operating and geometric parameters. These factors include the effects of blade geometry on ice accretion, droplet collision efficiency, droplet distribution spectrum, and median volume diameter under different ambient conditions pertaining to wind speed and tip speed ratios experienced by both the reference collector and wind turbine blade. The results presented in this paper provide a simplistic explanation about k‐factor variance; however, further validation is necessary, in particular when it comes to the ice accretions on different wind turbine blade profiles under different operating and geometric conditions.
Research Data Stewardship for Healthcare Professionals
Authors: Jansen Paula , van den Berg Linda , van Overveld Petra , Boiten Jan-Willem 
Published: December 2018

AbstractResearch data stewardship refers to the long-term and sustainable care for research data, from study design to data collection, analysis, storage, and sharing. It involves all activities that are required to ensure that digital research data is findable, accessible, interoperable, and reusable (FAIR) in the long term, including data management, archiving, and reuse by third parties. This chapter provides an overview of the aspects of FAIR data stewardship that you should consider when you are involved in clinical research.
Extracting Features from Time Series
Authors: Herff Christian , Krusienski Dean J. 
Published: December 2018

AbstractClinical data is often collected and processed as time series: a sequence of data indexed by successive time points. Such time series can be from sources that are sampled over short time intervals to represent continuous biophysical wave-(one word waveforms) forms such as the voltage measurements representing the electrocardiogram, to measurements that are sampled daily, weekly, yearly, etc. such as patient weight, blood triglyceride levels, etc. When analyzing clinical data or designing biomedical systems for measurements, interventions, or diagnostic aids, it is important to represent the information contained within such time series in a more compact or meaningful form (e.g., noise filtering), amenable to interpretation by a human or computer. This process is known as feature extraction. This chapter will discuss some fundamental techniques for extracting features from time series representing general forms of clinical data.
Prediction Modeling Methodology
Authors: Dankers Frank J. W. M. , Traverso Alberto , Wee Leonard , van Kuijk Sander M. J. 
Published: December 2018

AbstractIn the previous chapter, you have learned how to prepare your data before you start the process of generating a predictive model. In this chapter, you will learn how to make a predictive model using very common regression techniques and how to evaluate the performance of a model. In the next chapter we will then look at more advanced machine learning techniques that have become increasingly popular in recent years.
A composite pNGB leptoquark at the LHC
Authors: Alvarez Ezequiel , Da Rold Leandro , Juste Aurelio , Szewc Manuel , Schroeder Tamara Vazquez 
Published: December 2018

Abstract

The measurements of R

K

(∗)
and R

D

(∗)
by BaBar, Belle and the LHCb collaborations could be showing a hint of lepton flavor universality violation that can be accommodated by the presence of suitable leptoquarks at the TeV scale. We consider an effective description, with leptoquarks arising as composite pseudo Nambu-Goldstone bosons, as well as anarchic partial compositeness of the SM fermions. Considering the R

K

(∗)
anomaly within this framework, we study pair production of

$$ {S}_3\sim {\left(\overline{3},3\right)}_{1/3} $$

S
3

∼

3
¯

3

1
/
3

at the LHC. We focus on the component S
3
1/3
of the triplet, which decays predominantly into tτ and bν, and study the bounds from existing searches at

$$ \sqrt{s}=13 $$

s

=
13

TeV at the LHC. We find that sbottom searches in the

$$ b\overline{b}+{E}_{\mathrm{T}}^{\mathrm{miss}} $$

b

b
¯

+

E
T
miss

final state best explore the region in parameter space preferred by our model and currently exclude S
3
1/3
masses up to ∼1 TeV. Additional searches, considering the tτ and tμ decay modes, are required to probe the full physical parameter space. In this paper we also recast existing studies on direct leptoquark searches in the tτ tτ channel and SM

$$ t\overline{t}t\overline{t} $$

t

t
¯

t

t
¯

searches, and obtain the regions in parameter space currently excluded. Practically the whole physical parameter space is currently excluded for masses up to ∼0.8 TeV, which could be extended up to ∼1 TeV with the full Run 3 dataset. We conclude that pair production searches for this leptoquark can benefit from considering the final state tτ b + E
T
miss
, where the largest branching ratio is expected. We appraise that future explorations of leptoquarks explaining the B-anomalies with masses beyond the TeV should also consider single and non-resonant production in order to extend the mass reach.
The effectiveness of patterned laser trabeculoplasty over 6 months period: A cohort study
Authors: Al Zubi Khalid , Alsalem Khalil 
Published: December 2018

ABSTRACT

Introduction:
To evaluate the efficacy of pattern laser trabeculoplasty (PLT) as a treatment for lower intraocular pressure among patients with primary open-angle glaucoma.

Methods:
Cohort case study has been used as the study design. A total of 85 patients with bilateral open-angle glaucoma underwent bilateral pattern laser trabeculoplasty (PLT) to reduce intraocular pressure (IOP). The initial and consequent intraocular pressure of all the patients was evaluated at 3 months and 6 months. IOP results were compared before treatment and after 3 and 6 months of receiving treatment, using the paired T-test.

Results:
The average intraocular pressure in the right eye was decreased from the pre-treatment level at 22.1 mm hg (+/− 0.78) to 18.8 mm hg (+/− 0.83), after six months following the treatment. It represented a 14.9% reduction of average intraocular pressure, which is statistically significant with a P- value 0.036, using Paired T-Test. On the contrary, the average intraocular pressure in the left eye decreased from the pre-treatment level at 22.7 mm hg (+/− 0.62) to 19.2 mm hg (+/− 0.80), representing 15.4% reduction of the average intraocular pressure.

Conclusion:
The results have shown that pattern laser trabeculoplasty is a potential useful tool in treating open angle glaucoma.

Highlights:
Impact and Safety Associated with Accidental Dislodgement of Vascular Access Devices: A Survey of Professions, Settings, and Devices
Authors: Moureau Nancy 
Published: December 2018

Abstract
Background: Dislodgement rates with intravenous catheters are reported at 1.8%–24% events per year resulting in failed access, interrupted treatment, and greater resource consumption with catheter replacement. The purpose of this study was to quantitatively evaluate the perceptions of frequency, impact, contributing factors, and safety issues from accidental dislodgement affecting intravenous (IV) devices as reported by healthcare clinicians.
Methodology: A cross-sectional descriptive survey was conducted via a voluntary online web-based survey of clinicians. Subjects were divided as those actively working in a clinical healthcare setting and those no longer active. Analysis of data was performed quantifying responses of clinicians on question of dislodgement.
Results: Survey results indicate clinicians routinely observe a significant percentage of accidental dislodgement, with 68% of the 1561 respondents reporting often, daily, or multiple times daily occurrence and 96.5% identifying peripheral intravenous catheters as most common device experiencing accidental dislodgement. Respondents prioritized 10 contributing factors, with confused patient (80%), patient physically removes catheter (74%), and IV catheter tape or securement loose (65%) as the top 3 causes. Over 95% of respondents consider IV dislodgement a safety risk to patients.
Conclusions: This study reports perceptions and impact of accidental dislodgement with IV devices. Inconsistencies exist with use, application, and management of catheter securement and dressings for IV catheters. Risk of additional complications and complete device failure are increased when dislodgement occurs. Given possible complications, along with necessitating replacement of the IV device in many cases, IV catheter dislodgement was considered a safety risk to patients by nearly all respondents.
The Things that Help, the Things that Get in the Way: Working Together to Improve Outcome Following Acquired Brain Injury
Authors: Douglas Jacinta M. 
Published: December 2018

Working in neurological rehabilitation brings with it numerous opportunities to gain an understanding of the factors that contribute to shaping meaningful living and wellbeing for those tackling the major life changes encountered following acquired brain injury (ABI). These opportunities come in many forms: challenging and brave clients, wise and worrying families, questioning and inspiring colleagues, empowering and limiting work environments and rigid and advancing policy and legislative contexts.Our personal and collective understanding ofthe things that helpandthe things that get in the wayof effective rehabilitation continuously emerges from the convergence of the experience and knowledge afforded by these opportunities. The aim of this paper is to considerthe things that helpandthe things that get in the wayas they have been identified by people with ABI, their families and those who work with them and have been further evidenced through research targeted towards improving short, medium and long-term outcomes for those living with the consequences of ABI. Thesethingsas discussed in this paper capture the essential role of the self, the importance of rights and access to rehabilitation, the impact of the family and the contribution of social connection.
A new species of Raphidascaris (Nematoda: Raphidascarididae) infecting the fish Gymnogeophagus balzanii (Cichlidae) from the Pantanal wetlands, Brazil and a taxonomic update of the subgenera of Raphidascaris based on molecular phylogeny and morphology
Authors: Malta L.S. , Paiva F. , Elisei C. , Tavares L.E.R. , Pereira F.B. 
Published: December 2018

Abstract
Raphidascaris (Sprentascaris) andersoni n. sp. (Nematoda: Raphidascarididae) collected in the intestine of the humphead cichlid Gymnogeophagus balzanii (Perugia) from the Pantanal wetlands, State of Mato Grosso do Sul (Brazil) is described and genetically characterized. The new species differs from its congeners mainly by having a conspicuous papilla-like formation slightly anterior to the cloacal aperture. Furthermore, males of R. (S.) lanfrediae and R. (S.) mahnerti have caudal alae, and R. (S.) hypostomi and R. (S.) pimelodi lack lateral alae, whereas in the new species caudal alae are absent and lateral alae present. The remaining congeners, namely, R. (S.) marano and R. (S.) saltaensis differ from Raphidascaris (Sprentascaris) andersoni n. sp. mainly because males have three pairs of postcloacal papillae (vs five pairs). In the phylogenetic reconstructions, using three nuclear genetic markers (18S, ITS1-5.8S-ITS2 and 28S rDNA) and one mitochondrial (cox1 mtDNA), the new species was separated from other representatives of Raphidascarididae, and the absence of monophyly in Hysterothylacium and Raphidascaroides was confirmed. Moreover, the subgenera Sprentascaris and Ichthyascaris appeared to be monophyletic. Therefore, even though Raphidascaris (Raphidascaris) was apparently not monophyletic, the subgenera of Raphidascaris should be re-erected as valid genera. The updated diagnoses of Ichthyascaris, Raphidascaris and Sprentascaris are given. The present study represents the first parasitological survey in G. balzanii.
The changing practices of frontline diplomacy: New directions for inquiry
Authors: Cooper Andrew F. , Cornut Jérémie 
Published: December 2018

AbstractThis article develops the concept of ‘frontline diplomacy’ – what practitioners referring to work in embassies, consulates, and permanent representation as ‘the field’ –, defined here as all diplomats’ activities taking place away from headquarters. IR scholarship tends to focus on Ministries of Foreign Affairs located in capitals. On the contrary, building on the practice turn in IR, we first show that international politics emerge from frontline practices. Adding to criticism against the practice turn, we then explain that it has missed important transformations occurring in frontline diplomacy because it tends to privilege stability over change. We finally discuss two innovations in frontline practices: the action of Sherpas in G20 summits following the 2008 crisis and the use of Twitter by US Ambassador to Russia Michael McFaul (2012–14). For each we answer three questions: How do these activities transform traditional modes of operation? How are non-state actors involved in them? What do they tell about transformation of global politics? Because diplomatic practices at the frontlines epitomise international politics, these new directions for inquiry contribute substantively to IR scholarship. At the theoretical level, they enrich the continuing encounter between IR and diplomatic studies through practice theory and help to understand change in practice.
Beat wave cyclotron heating of rippled density plasma
Authors: Pushplata  , Vijay A. 
Published: December 2018

AbstractLaser beat wave heating of magnetized plasma via electron cyclotron damping is proposed and analyzed. A plasma density ripple is presumed to exist across the magnetic field. Two collinear lasers propagating along the magnetic field exert a beat frequency ponderomotive force on electrons, driving a large amplitude Bernstein quasi-mode which suffers cyclotron damping on electrons. Finite Larmor radius effects play an important role in the heating. Electron temperature initially rises linearly with time. As the temperature rises cyclotron damping becomes stronger and temperature rises rapidly. The process, however, requires ripple wavelength shorter than the wavelength of the beat wave.
Catheter-directed therapy for acute pulmonary embolism in children
Authors: Akam-Venkata Jyothsna , Forbes Thomas J. , Schreiber Theodore , Kaki Amir , Elder Mahir , Turner Daniel R. , Kobayashi Daisuke 
Published: December 2018

AbstractBackgroundAcute pulmonary embolism is a life-threatening condition and rarely occurs in children. In adults, catheter-directed therapy emerges as a potentially safer and effective therapeutic option. However, there is a paucity of data on the safety and efficacy of catheter-directed therapy for pulmonary embolism in children. We report a single-centred experience of catheter-directed therapy for acute pulmonary embolism in children.MethodsThis is a retrospective study of children who had no CHD and underwent catheter-directed therapy at Detroit Medical Center during a 12-year period from 2005 to 2017. Demographic and clinical data associated with pulmonary embolism were collected along with the outcome.ResultsA total of nine patients of median age 16 years with the range from 12 to 20 received catheter-directed therapy for sub-massive (n = 6) and massive pulmonary embolism (n = 3). Among nine patients, one patient received Angiojet thrombectomy and balloon angioplasty, whereas eight patients received catheter-directed thrombolysis using tissue plasminogen activator through infusion catheters (n = 3) or EkoSonic ultrasound-accelerated thrombolysis system (n = 5). In four out of five patients treated with EkoSonic, significant clinical improvement was noticed within 24 hours. Among seven patients who survived, two patients had minor gastrointestinal bleeding with median hospital stay of 8 days with the range from 5 to 24 days, and two patients with massive pulmonary embolism died possibly due to delayed institution of catheter-directed therapy.ConclusionCatheter-directed therapy with/without EkoSonic is an emerging alternative therapy for sub-massive and massive pulmonary embolism in children. A timely institution of catheter-directed therapy appeared important to improve the outcome.
Interactive intentionality and norm formation
Authors: Guarnieri Pietro 
Published: December 2018

AbstractThe paper aims at complementing Searle's social ontology with an epistemology capable of illustrating institution formation. To this purpose, I discuss Searle's conception of constitutive rules and show that it requires the specifications of normative powers and purposes identifying status functions to be taken as given. However, such specifications arise from underlying normative commitments that may be various and possibly conflicting. Hence, in order to account for the formation of institutions, it is necessary to understand how status function declarations may emerge from alternative normative commitments. I make the hypothesis of “interactive intentionality,” as an interactive and deliberative mode of practical reasoning, to describe the processes of convergence on definite constitutive rules. These processes show how interactive intentionality may frame both commitment and enforcement, thus providing some insights to make rule-based and equilibrium-based accounts of institutions epistemologically commensurable.
Interference and Control of ALS-Resistant Mouse-Ear Cress (Arabidopsis thaliana) in Winter Wheat
Authors: Randhawa Ranjeet S. , Westwood James H. , Cahoon Charles W. , Flessner Michael L. 
Published: December 2018

AbstractIn 2015, winter wheat growers in Virginia reported commercial failures of thifensulfuron to control mouse-ear cress. This was the first reported case of field-evolved acetolactate synthase (ALS) resistance in mouse-ear cress, so research was conducted to evaluate alternative herbicide options as well as to document potential yield loss in winter wheat from mouse-ear cress. Efficacy studies were conducted at three site-years in 2015 to 2016 and 2016 to 2017 as well as a POST greenhouse trial. In the PRE study, flumioxazin, pyroxasulfone, saflufenacil, and metribuzin resulted in more than 80% mouse-ear cress control 15 wk after planting across all sites with no observable wheat injury. No differences were observed in wheat yield in two of three sites in the PRE herbicide study; yield differences were attributed to common chickweed and not to mouse-ear cress. In the POST herbicide study, 2,4-D, dicamba, and metribuzin resulted in greater than 75% control in the field and greenhouse. Metribuzin, dicamba, and pyroxsulam resulted in crop injury 3 wk after treatment at some sites, but injury was transient. Yield from all POST treatments was similar to the nontreated plots. No yield loss was observed by mouse-ear cress densities greater than 300 plants m–2, indicating that mouse-ear cress is not very competitive with winter wheat. Growers should make herbicide decisions based on other weeds in the field and can incorporate the aforementioned herbicides for mouse-ear cress control.
Tolpyralate Efficacy: Part 2. Comparison of Three Group 27 Herbicides Applied POST for Annual Grass and Broadleaf Weed Control in Corn
Authors: Metzger Brendan A. , Soltani Nader , Raeder Alan J. , Hooker David C. , Robinson Darren E. , Sikkema Peter H. 
Published: December 2018

AbstractTolpyralate is a new Group 27 pyrazolone herbicide that inhibits the 4-hydroxyphenyl-pyruvate dioxygenase enzyme. In a study of the biologically effective dose of tolpyralate from 2015 to 2017 in Ontario, Canada, tolpyralate exhibited efficacy on a broader range of species when co-applied with atrazine; however, there is limited published information on the efficacy of tolpyralate and tolpyralate+atrazine relative to mesotrione and topramezone, applied POST with atrazine at label rates, for control of annual grass and broadleaf weeds. In this study, tolpyralate applied alone at 30 g ai ha−1 provided >90% control of common lambsquarters, velvetleaf, common ragweed, Powell amaranth/redroot pigweed, and green foxtail at 8 weeks after application (WAA). Addition of atrazine was required to achieve >90% control of wild mustard, ladysthumb, and barnyardgrass at 8 WAA. Tolpyralate+atrazine (30+1,000 g ai ha−1) and topramezone+atrazine (12.5+500 g ai ha−1) provided similar control at 8 WAA of the eight weed species in this study; however, tolpyralate+atrazine provided >90% control of green foxtail by 1 WAA. Tolpyralate+atrazine provided 18, 68, and 67 percentage points better control of common ragweed, green foxtail, and barnyardgrass, respectively, than mesotrione+atrazine (100+280 g ai ha−1) at 8 WAA. Overall, tolpyralate+atrazine applied POST provided equivalent or improved control of annual grass and broadleaf weeds compared with mesotrione+atrazine and topramezone+atrazine.