bluuebunny/crossref_metadata_2025_split huggingface dataset:
Long noncoding RNA DQ786243 interacts with miR‐506 and promotes progression of ovarian cancer through targeting cAMP responsive element binding protein 1
Authors: Yan Huan , Silva Maria A. , Li Hong , Zhu Linlin , Li Pengyun , Li Xia , Wang Xiaofang , Gao Junjun , Wang Ping , Zhang Zhan 
Published: August 2018

AbstractLong noncoding RNAs (lncRNAs) have been reported to be abnormally expressed in several cancers and associated with the proliferation of cancer cells. The objective of this study was to investigate the role and the underlying mechanisms of DQ786243 in ovarian cancer. In the current study, DQ786243 was specifically upregulated in ovarian cancer tissues and cell lines. Knockdown of DQ786243 inhibited the ability of cell migration, invasion, proliferation, colony formation and wound healing, whereas promoted cell apoptosis and induced G0/G1 cell cycle arresting. By using online tools and mechanistic analysis, we demonstrated that DQ786243 could directly bind to microRNA‐506 (miR‐506) and downregulate its expression. Moreover, DQ786243 reversed the inhibitory effect of miR‐506 on the growth of ovarian cancer cells, which might be involved in the derepression of cAMP responsive element binding protein 1 (CREB1) expression. Further investigation into the mechanisms showed that knockdown of DQ786243 inhibited the epithelial to mesenchymal transition (EMT) process in ovarian cancer cells. Finally, xenograft experiments further confirmed that knockdown of DQ786243 notably suppressed the proliferation and EMT process in vivo. Taken together, our study showed for the first time that DQ786243 interacted with miR‐506 and promoted progression of ovarian cancer via targeting CREB1 in ovarian cancer. The results might help to probe the feasibility of lncRNA‐directed therapy for this deadly disease.
Influence of lag length on repetition priming in emotional stimuli:ERPevidence
Authors: Zhang Delin , Nie Aiqing , Wang Zhixuan , Li Mengsi 
Published: August 2018

BackgroundPrevious studies have demonstrated both behavioral and neural evidence for the potential mediations of lag length and pre‐existing memory representation on repetition priming. However, such mediations on emotional stimuli have not been described.MethodsThe current experiment intended to disentangle lag length from pre‐existing memory representation. A lexical decision task was performed, in which different emotional characters (either normal or transposed) were re‐presented either immediately or delayed.ResultsIn immediate repetition, one early and two late (ie, N400 and late positive complex) repetition‐related event‐related potential (ERP) effects were elicited, but these were not sensitive to pre‐existing memory representation. The delayed repetition case merely observed the N400.ConclusionThese results suggest that the repetition‐related priming effect is neutrally sensitive to lag length. Emotional information potentially exerts early and later influences in the processing underlying stimuli memory.
Relative abundances of novel cyclic prodelphinidins in wine depending on the grape variety
Authors: Longo Edoardo , Merkyte Vakare , Rossetti Fabrizio , Teissedre Pierre‐Louis , Jourdes Michael , Boselli Emanuele 
Published: August 2018

AbstractThe identification of cyclic B‐type procyanidins in grape and wine was recently disclosed. Some of these were also found in berries of totally different vegetal species (eg, Vaccinium sp.). However, presence of a wider class of these cyclic condensed tannin compounds with variably substituted monomers has never been addressed so far. Here, an extended list of oligomeric cyclic proanthocyanidins (PAC) bearing variable substitution patterns on the main flavan‐3‐ol unit has been searched in wines. Nearly 7600 theoretical structures were calculated and searched in red and white wine samples made from different grape varieties. Moreover, a hydrogen/deuterium exchange approach (already applied to a cyclic tetrameric procyanidin) coupled to high‐resolution mass spectrometry was applied to confirm their cyclic B‐type structure rather than a non cyclic A‐type structure, otherwise isomeric and undistinguishable by LC‐MS alone. The main group of novel cyclic PAC observed is shown to contain (epi)gallocatechin beside (epi)catechin as the constituent monomers.
Psychotropic medication use during pregnancy
Authors: Niethe Miranda , Whitfield Karen 
Published: August 2018

AbstractGlobally, mental health‐related issues are a growing concern. Pregnant women with mental health‐related illnesses present a unique challenge to health professionals. During pregnancy, the decision to withhold, modify or continue psychotropic medication requires consideration of both maternal and infant outcomes. Health professionals must be aware withdrawal of these medications during pregnancy can often lead to symptom relapse. Decisions around medication management during pregnancy can be challenging due to the lack of data and occasionally conflicting data regarding safety. It is essential that women do not receive conflicting information from health professionals because this can lead to confusion and both intentional and unintentional non‐adherence. Recently, it has been suggested that pharmacists may help optimise medication management and patient outcomes in perinatal care. This review outlines the use of psychotropic medications in pregnancy and discusses key considerations for those involved in providing clinical care to pregnant women with mental illness.
Influence of manganese dioxide and Ba2Co2Fe12O22‐additives on the magnetic power loss of Ni0.8Zn0.2Fe2O4 ferrites
Authors: Ni J.L. , Feng S.J. , Liu X.S. 
Published: August 2018

AbstractManganese dioxide and Ba2Co2Fe12O22 added Ni0.8Zn0.2Fe2O4 ferrites were prepared by solid state reaction process. The structure and magnetic properties of the ferrites were investigated by X‐ray diffractometer and magnetic flux density‐magnetic field analyzer. It was found that the magnetic loss shows increase‐decrease‐increase variation trend with the increase of manganese dioxide additive concentration, and the optimal concentration of manganese dioxide doping is about 1.2 wt.%. Compared with the sample without manganese dioxide doping, further investigation revealed that the hysteresis loss coefficient and eddy current loss coefficient decreased in 1.2 wt.% manganese dioxide doping nickel zinc ferrite, but the residual loss coefficient increased with manganese dioxide doping.
Conventional and in situ tensile test of friction stir welded steel – Optimization of processing parameters
Authors: Husain M.M. , Ghosh M. , Sarkar R. , Pal T.K. , Prabhu N. 
Published: August 2018

AbstractIn the present investigation, steel plates were joined at different tool traversing speed by friction stir welding keeping other parameters same. Microstructural characterization was carried out with optical and scanning electron microscopes. At weld nugget pearlite and bainite were present within ferrite matrix. Thermo‐mechanically and heat affected zones microstructure consisted of pearlite and ferrite. Second phase area fraction and matrix grain size at different regions were varied depending on welding parameters. Weld nugget exhibited substantial improvement in microhardness with respect to base metal. In this respect heat affected zone revealed minimum microhardness and was below base metal value. Tensile tests were carried out on standard and miniature specimens in scanning electron microscope. Highest joint efficiency to the tune of ∼82 % and ∼120 % of that of base metal obtained for standard and miniature specimens, respectively machined from weld fabricated at lowest welding speed. With increment in welding speed assembly strength was reduced for both types of specimens. Standard specimens failed from heat affected zone and miniature specimens failed through centre of weld nugget. Apart from matrix grain size and second phase area fraction, precipitation of microalloyed carbide / carbonitride was responsible for altering the joint strength.
The investigation of the tensile behaviors of single L‐joint type bonded with adhesive and rivet
Authors: Kurtkan Ü. , Adin H. 
Published: August 2018

AbstractIn this study, tensile behaviour of single “L” type joints was investigated experimentally and numerically. Aluminium pieces with 2 mm, 3 mm and 4 mm thicknesses were used as joint materials. Overlap lengths were chosen as 10 mm, 15 mm and 20 mm. Joints were executed with two different rivets as steel and aluminium and 3 M 2216 epoxy based adhesive. Experiments were carried out by means of Shimadzu universal testing machine with 5 kN load cell. While the numerical study was carried out, using ANSYS Workbench, finite element analysis program, models were formed with the same properties as experimental works. Results showed that the samples with 20 mm overlap length had the highest strength of all models. Models with steel rivet had higher strength than models with aluminium rivets for all overlap lengths.
Irrational decision making: Cultural influence on environmental nonprofit organizations' advocacy strategies
Authors: Liu Li‐Yin 
Published: August 2018

The determinants of environmental nonprofit organizations' (ENPOs) advocacy strategies is particularly important in East Asian countries, such as Taiwan, in which the public values harmony and aggressive movements are often controversial because of the influence of Confucianism. What triggers ENPOs in Taiwan to initiate aggressive environmental protests is consequently a question worth investigating. Accordingly, this study sought answers to the unasked question: How do ENPOs' decision makers decide what types of advocacy activities to pursue? To answer this question, this study utilized cultural theory (CT) to develop hypotheses to test data collected through an online survey in Taiwan.The evidence confirms what CT predicted. ENPOs' decision making on advocacy activities is neither affected by their organizational scale/resources nor the effectiveness and acceptance of environmental activities. Instead, ENPOs' organizational culture plays a crucial role, especially in explaining advocacy activities that are relatively controversial and less accepted by the Taiwanese public. ENPOs that have egalitarian and individualistic organizational cultures are more likely to initiate every type of environmental activity, especially protest‐based activities. Based on the results, organizational culture may be useful in explaining the bounded rationality behind decision making.This result also indicates that ENPOs in Taiwan should plan more carefully before initiating activities. Actions without careful planning may result in resource waste and legitimacy challenges. The results of this study can be beneficial for ENPOs to reconsider their decision making regarding environmental advocacy.
Modafinil and the risk of cardiovascular events: Findings from three US claims databases
Authors: Kaplan Sigal , Goehring Earl L. , Melamed‐Gal Sigal , Nguyen‐Khoa Bao‐Anh , Knebel Helena , Jones Judith K. 
Published: August 2018

AbstractPurposeThis study examined the potential risk of cardiovascular (CV) events associated with modafinil and the consistency of the risk estimates across databases.MethodsA retrospective, inception cohort design of patients who initiated treatment with modafinil between 2006 and 2008 was used in three US health care claims databases. Modafinil users were matched with nonusers. Patients were further divided into two cohorts of obstructive sleep apnea (OSA) and non‐OSA (NOSA) cohorts. Endpoints of interest, including myocardial infarction (MI), stroke, CV hospitalizations, and all‐cause death, were assessed using incidence rates and Cox proportional hazard ratios (HRs), adjusted for potential confounding factors.ResultsThe cohorts included a total of 175 524 patients in MarketScan CM; 77 266—in IMS LifeLink; and 8174—in MarketScan Medicaid. No increased risk for MI in the OSA and NOSA cohorts was observed across all three databases. The risks of CV hospitalization in the OSA and NOSA cohorts were not different between the modafinil users and nonusers, except for IMS LifeLink database where the HR was lower than one in the modafinil users compared with the nonusers (HR, 0.69; 95% confidence interval [CI], 0.54 to 0.87). For OSA patients with prior stroke, an adjusted HR of 1.96 (95% CI, 1.02 to 3.76) was observed for stroke among modafinil users compared with nonusers. Among the NOSA, the HRs for all‐cause death in the OSA were inconsistent across databases.ConclusionsExcept for few CV outcomes, applying one common protocol generated consistent risk estimates of CV events following modafinil use across cohorts and databases.
Organic Solar Cell Materials toward Commercialization
Authors: Xue Rongming , Zhang Jingwen , Li Yaowen , Li Yongfang 
Published: August 2018

AbstractBulk‐heterojunction organic solar cells (OSCs) have received considerable attention with significant progress recently and offer a promising outlook for portable energy resources and building‐integrated photovoltaics in the future. Now, it is urgent to promote the research of OSCs toward their commercialization. For the commercial application of OSCs, it is of great importance to develop high performance, high stability, and low cost photovoltaic materials. In this review, a comprehensive overview of the fundamental requirements of photoactive layer materials and interface layer materials toward commercialization is provided, mainly focusing on high performance, green manufacturing, simplifying device fabrication processes, stability, and cost issues. Furthermore, the perspectives and opportunities for this emerging field of materials science and engineering are also discussed.
Intentions: The dynamic hierarchical model revisited
Authors: Mylopoulos Myrto , Pacherie Elisabeth 
Published: August 2018

Ten years ago, one of us proposed a dynamic hierarchical model of intentions that brought together philosophical work on intentions and empirical work on motor representations and motor control (Pacherie, 2008). The model distinguished among Distal intentions, Proximal intentions, and Motor intentions operating at different levels of action control (hence the name DPM model). This model specified the representational and functional profiles of each type of intention, as well their local and global dynamics, and the ways in which they interact. A core insight of the model was that action control is the result of integrated, coordinated activity across these levels of intention. Since the proposal of the model, empirical and theoretical works in philosophy and cognitive science have emerged that would seem to support and expand on this central insight. In particular, an updated understanding of the nature of sensorimotor processing and motor representations, as well as of how the different levels of intention and control interface and interact, allows for the further specification and precisification of the original DPM model.This article is categorized under:Philosophy > Psychological CapacitiesPsychology > Motor Skill and PerformancePhilosophy > Action
Safety Culture and Perioperative Quality at the Volta River Authority Hospital in Akosombo, Ghana
Authors: Smiley Katherine , Ofori Love , Spangler Cindy , Acquaah‐Arhin Rebecca , Deh Deborah , Enos Juliana , Manortey Stephen , Baiden Frank , Finlayson Samuel , Price Raymond , McCrum Marta 
Published: August 2018

AbstractBackgroundThe Volta River Authority Hospital (VRAH) is a district hospital associated with a large public works project in Akosombo, Ghana, that has developed a reputation for high‐quality care. We hypothesized that this stems from a culture of safety and standardized processes typical of high‐risk engineering environments. To investigate this, we evaluated staff and patient perceptions of safety and quality, as well as perioperative process variability.Materials and methodsThe Safety Attitudes Questionnaire (SAQ) and Hospital Consumer Assessment of Healthcare Providers and Systems (HCAHPS) surveys were used to evaluate staff and patient perceptions of safety. Perioperative general surgery and obstetrical procedure observations generated process maps, which were analyzed for variability and waste.ResultsThirty‐one SAQs were administered. 83% of workers held a positive perception of teamwork, and 77.4% held a positive perception of safety culture. Fifteen HCAHPS surveys of surgical inpatients showed a median hospital rating of 10 [IQR 8.5–10] on a ten‐point scale. 90% gave maximal scores for pain management and 84.4% for nurse communication. Ten general surgery and obstetrical procedures were observed for which process map analysis was notable for no consistent waste steps and 100% adherence to the World Health Organization Safe Surgery Checklist.ConclusionsSurveys suggest an institutional commitment to safety with strong teamwork culture and patient communication. Perioperative process mapping supports this culture, with low levels of variability and waste, and is useful for evaluating standardization of care. VRAH demonstrates the feasibility of delivering high standards of perioperative care in a low‐resource setting.
Assessing Shared Decision‐Making Clinical Behaviors Among Genetic Counsellors
Authors: Birch Patricia H. , Adam S. , Coe R. R. , Port A. V. , Vortel M. , Friedman J. M. , Légaré F. 
Published: August 2018

AbstractShared decision‐making (SDM) is a collaborative approach in which clinicians educate, support, and guide patients as they make informed, value‐congruent decisions. SDM improves patients' health‐related outcomes through increasing knowledge, reducing decisional conflict, and enhancing experience of care. We measured SDM in genetic counselling appointments with 27 pregnant women who were at increased risk to have a baby with a genetic abnormality. The eight experienced genetic counsellors who participated had no specific SDM training and were unaware that SDM was being assessed. Audio transcripts of appointments were scored using ‘Observing Patient Involvement in Decision Making' (OPTION12). Patients' anxiety and decisional conflict were also assessed. The genetic counsellors' mean OPTION12score was 42.4% (SD 9.0%; possible range 0–100%). Specific SDM behaviours that scored highest included introducing the concept of equipoise and listing all options with their pros and cons. Behaviours that scored lowest included eliciting patients' preferred approach to receiving information and desired degree of involvement in decision‐making. Patients' levels of anxiety and decisional conflict were unassociated with genetic counsellors' OPTION12scores. Some SDM behaviours were better demonstrated in this prenatal genetic counselling study than others. Formal training of genetic counsellors in SDM may enhance use of this approach in their professional practice.
Quantum changes in self‐efficacy and condom‐use intention among youth: A chained cusp catastrophe model
Authors: Yu Bin , Chen Xinguang , Stanton Bonita , Chen Ding‐Geng (Din) , Xu Yunan , Wang Yan 
Published: August 2018

ABSTRACTIntroductionThe complex relationships among HIV knowledge, condom‐use skills, self‐efficacy, peer influence and intention to use condoms have been rigorously investigated. However, studies guided by a linear behavior change model often explain only a limited amount of variances. This study aims to advance our understanding of the relationships through a nonlinear quantum change paradigm.MethodsData (n = 1970, 40.61% male, mean age 16.94 ± 0.74) from a behavioral intervention program among high school students in the Bahamas were analyzed with a chained cusp catastrophe model in two steps. In the first step, self‐efficacy was analyzed as the outcome with HIV knowledge/condom‐use skills as asymmetry variables and peer influence as bifurcation variable. In the second step, condom‐use intention was analyzed as the outcome while self‐efficacy (outcome in the first step) was used as bifurcation variable allowing peer influence as bifurcation, and HIV knowledge/condom‐use skills were included as asymmetry. Cusp modeling analysis was conducted along with equivalent linear models.ResultsThe cusp model performed better than the linear and logistic models. Cusp modeling analyses revealed that peer influence significantly bifurcated the relationships between HIV knowledge/condom‐use skills and self‐efficacy; while both self‐efficacy and peer influence significantly bifurcated the relationship between HIV knowledge/condom‐use skills and condom‐use intention.ConclusionOur findings support the central role of self‐efficacy and peer influence as two chains in bridging the complex quantum relationships between HIV knowledge/condom‐use skills and condom‐use intention among adolescents. The nonlinear cusp catastrophe modeling provided a new method to advance HIV behavioral research.
Interventions for involuntary psychiatric inpatients: A systematic review
Authors: Giacco Domenico , Conneely Maev , Masoud Tumseela , Burn Erin , Priebe Stefan 
Published: August 2018

AbstractBackground:Observational research has found that involuntary treatment provides limited benefits in terms of long-term clinical outcomes. Our aim was to review literature on existing interventions in order to identify helpful approaches to improve outcomes of involuntary treatment.Methods:This systematic review follows the Preferred Reporting Items for Systematic Reviews and Meta‐Analyses (PRISMA) statement guidelines. Seven databases (AMED, PsycINFO, Embase Classic, Embase 1974–2017, CINAHL, MEDLINE, and BNI) were searched and the results were analysed in a narrative synthesis.Results:Nineteen papers describing fourteen different interventions were included. Using narrative synthesis the interventions were summarised into three categories: a) structured patient-centred care planning; b) specialist therapeutic interventions; c) systemic changes to hospital practice. The methodologies used and outcomes assessed were heterogeneous. Most studies were of low quality, although five interventions were tested in randomised controlled trials (RCTs). Preliminary evidence supports structured patient-centred care planning interventions have an effect on long-term outcomes (such as readmission), and that specialist therapeutic interventions and systemic changes to hospital practice have an effect on reducing the use of coercive measures on wards.Conclusions:This review shows that it is possible to conduct rigorous intervention-testing studies in involuntary patients, including RCTs. Yet, the overall evidence is limited. Structured patient-centred care planning interventions show promise for the improvement of long-term outcomes and should be further evaluated.