bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cement pressurizing reduces radiolucent lines at glenoid: A randomized, multicentric study
Authors: Kasten Philip , Raiss Patric , Zeifang Felix , Stangl Richard , Greiner Stefan , Zumstein Matthias , Nowotny Jörg , Schmitt Katrin , Schnetzke Marc , Reuther Falk , Frauenschuh Dirk 
Published: August 2019

Background The hypothesis of this study is that cement pressurization into the glenoid reduces the rate of radiolucent lines in total shoulder arthroplasty in the mean 25.5 months after the operation. Methods To examine this effect, a multicentric prospective randomized study (level of evidence 1) was initiated: one group (group P, n = 24) received intraoperative pressurization of cement into the cancellous bone of the glenoid, the other cement without pressure (group NoP, n = 27). Inclusion criteria were an osteoarthritis with glenoid erosion <15° and an intact rotator cuff. Results There were no significant differences preoperatively between the groups regarding age (mean age 66 ± 10 years (range 44–81)), gender, range of motion, scores and pathomorphology. Both groups had a significant improvement of the scores, strength, motion and satisfaction 25.5 months after the intervention. The scores were similar between the groups (ns). However, cement pressurization at the glenoid side significantly reduced the incidence of radiolucent lines (p < 0.027). Conclusion This supports the use of this simple technique to improve long-term survival of total shoulder arthroplasty. Level of evidence: 1
Open reduction and internal fixation of Gustilo type-I and type-II open pilon fractures using a lateral approach
Authors: Hu Chuanzhen , Zhu Weiyi , Chahal Kapil , Zhu Nan , Fang Wang , Jing Juehua , Zhan Junfeng 
Published: August 2019

Background: Traditional anteromedial incision for pilon fractures would further increase the damage to the subcutaneous tissues anterior and medial to tibia. In this study, we retrospectively evaluated the method and the outcomes of lateral approach for surgical treatment of Gustilo type-I and type-II open pilon fractures with medial soft tissue injuries. Methods: From May 2014 to September 2017, 35 patients with Gustilo type-I and type-II open pilon fractures were treated with standard protocol using a lateral approach. The initial wound debridement and application of a spanning external fixator or traction of calcaneal tubercle were performed within 24 h and a definitive fixation was performed when the wound was healed. The mean time from primary surgery to definite surgery was 11.8 (range: 8–16) days. Postoperative radiographs, complications, bone union, and American Orthopedic Foot and Ankle Society (AOFAS) ankle/hind foot score were recorded. Results: The mean follow-up period was 17 months (range: 13–23). The average time to bone union was 22 weeks (range: 18–25). In 35 patients, 2 patients had a superficial wound infection and another 1 patient showed limitation of ankle joint motion. No cases of deep infection, skin necrosis, and symptomatic implant reported. The mean AOFAS score was 89.8 (range: 84–95). On final outcome, 25 patients come under excellent and 10 patients had good result. Conclusion: From the results of this study, we can conclude that the lateral approach to treat Gustilo type-I and type-II open pilon fractures was a safe option with a low complication rate. On the other hand, it provides sufficient exposure to restore anatomic articulation, which is worthy of clinical recommendation.
Listening for the Interior in Hip-Hop and R&B Music
Authors: Allen Tennille Nicole , Randolph Antonia 
Published: August 2019

This article analyzes how four Black musical artists make “quiet,” or the inner life of African Americans, legible. Specifically, we consider ways that the quiet found within the lyrics of recent acclaimed albums from two hip-hop artists and two neo-soul artists—Kendrick Lamar’s DAMN (2017) and Rapsody’s Laila’s Wisdom (2017), Solange’s A Seat at the Table (2016) and Maxwell’s blackSUMMERS’night (2016), respectively—offer subtle, quotidian challenges to oppression, dehumanization, and objectification. We find that quiet occurs as artists describe the use of metaphysical space, or how place is used to make and take space for the self and to find peace, the protection of the interior self, and the gifts of quiet to the struggle for resistance. These lyrics speak to the interior safe space that Blacks seek as refuge from oppression by the dominant culture and demands from within their community. We contend that Blacks exercise power through their dominion over their interior selves, which in turn expresses their humanity. It is their control of the content of inner life, whatever those contents may be, that is an expression of sovereignty.
Circulating adhesion molecules and subclinical interstitial lung disease: the Multi-Ethnic Study of Atherosclerosis
Authors: McGroder Claire F. , Aaron Carrie P. , Bielinski Suzette J. , Kawut Steven M. , Tracy Russell P. , Raghu Ganesh , Barr R. Graham , Lederer David J. , Podolanczuk Anna J. 
Published: August 2019

Adhesion molecules may contribute to the development of interstitial lung disease (ILD) and have been proposed as prognostic biomarkers in idiopathic pulmonary fibrosis. Our objective was to determine whether the circulating adhesion molecules soluble intracellular adhesion molecule (sICAM)-1, soluble vascular cell adhesion molecule (sVCAM)-1 and P-selectin are associated with subclinical ILD in community-dwelling adults.The Multi-Ethnic Study of Atherosclerosis enrolled males and females aged 45–84 years from six communities in the United States in 2000–2002. High attenuation areas were defined as the percentage of imaged lung volume with attenuation −600–−250 HU on cardiac computed tomography (CT). Interstitial lung abnormalities were visually assessed on full-lung CT. Spirometry was performed on a subset of individuals. ILD hospitalisations and deaths were adjudicated.In fully adjusted analyses, higher levels of sICAM-1, sVCAM-1 and P-selectin were associated with greater high attenuation areas (2.94%, 95% CI 1.80–4.07%; 1.24%, 95% CI 0.14–2.35%; and 1.58%, 95% CI 0.92–2.23%, respectively), and greater rate of ILD hospitalisations (HR 1.36, 95% CI 1.03–1.80; 1.40, 95% CI 1.07–1.85; and 2.03, 95% CI 1.16–3.5, respectively). sICAM-1 was associated with greater prevalence of interstitial lung abnormalities (OR 1.39, 95% CI 1.13–1.71). sICAM-1 and P-selectin were associated with lower forced vital capacity (44 mL, 95% CI 12–76 mL and 29 mL, 95% CI 8–49 mL, respectively). sVCAM-1 and P-selectin were associated with increased risk of ILD death (HR 2.15, 95% CI 1.26–3.64 and 3.61, 95% CI 1.54–8.46, respectively).Higher levels of circulating sICAM-1, sVCAM-1 and P-selectin are independently associated with CT and spirometric measures of subclinical ILD, and increased rate of adjudicated ILD events among community-dwelling adults.
Comparation of the quantification of the proliferative index KI67 between eyeball and semi-automated digital analysis in gastro-intestinal neuroendrocrine tumors
Authors: Basile Maíra Leite , Kuga Fábio Seiji , Del Carlo Bernardi Fabíola 
Published: August 2019

Abstract
Background
Neuroendocrine tumors (NETs) constitute tumors widely distributed and with heterogeneous biological behavior. For gastrointestinal neuroendocrine tumors (GI-NETs) the following prognostic factors have been identified: location, production of hormones, size and proliferative grade. The latter must be calculated using proliferation index by the number of mitosis or the proportion of tumor cells positive for Ki67 immunostaining. The objective of this study was to use a quantitative tool to calculate the Ki67 index in GI-NETs.

Material and methods
We reviewed 40 cases of GI-NETs diagnosed at the Department of Pathological Sciences, Santa Casa de Misericórdia de São Paulo Hospital between 2004 and 2014 and compared the Ki67 index by manual count using scanned photomicrographs with semi-automated digital analysis (MC) and eyeball estimation (EE) of the histological slide.
After Ki67 immunostaining, the slides were scanned with 3DHistech Pannoramic Scanners. Hot spots were selected and exported in a high-resolution image format and the Ki67 index was calculated with semi-automated image analysis software (AxioVision 3.0). Ki67 immunoreactivity was expressed as the percentage of tumor cells with nuclear staining (number of positive tumor cells/a minimum of 500 total tumor cells).

Results
We compared the classification of the neuroendocrine tumor by using the two methods in the semi-automated method 26 maintained the same grade, while 14 were re-classified, 4 being upgraded and 10 downgraded.

Conclusion
In the EE method there was a larger estimate of the percentage of positivity for KI67. As the Ki67 values are the criteria for the classification of neuroendocrine tumors, the semi-automated method can have less error.
PIN-FORMED and PIN-LIKES auxin transport facilitators
Authors: Sauer Michael , Kleine-Vehn Jürgen 
Published: August 2019

ABSTRACT
The phytohormone auxin influences virtually all aspects of plant growth and development. Auxin transport across membranes is facilitated by, among other proteins, members of the PIN-FORMED (PIN) and the structurally similar PIN-LIKES (PILS) families, which together govern directional cell-to-cell transport and intracellular accumulation of auxin. Canonical PIN proteins, which exhibit a polar localization in the plasma membrane, determine many patterning and directional growth responses. Conversely, the less-studied non-canonical PINs and PILS proteins, which mostly localize to the endoplasmic reticulum, attenuate cellular auxin responses. Here, and in the accompanying poster, we provide a brief summary of current knowledge of the structure, evolution, function and regulation of these auxin transport facilitators.
Four Stereoisomers of 2-Aminomethyl-1-cyclopropanecarboxylic Acid: Synthesis and Biological Evaluation
Authors: Oikawa Masato , Sugeno Yuka , Tukada Hideyuki , Takasaki Yuichi , Takamizawa Satoshi , Irie Raku 
Published: August 2019

AbstractHere, we report a practical method for asymmetric synthesis of cyclopropane-fused GABA analogs. Starting from 2-furaldehyde, the cis-isomer (CAMP) was synthesized over 10 steps; (−)- and (+)-CAMP·HCl were synthesized by employing d- and l-menthol as the chiral auxiliary for total 2.5% and 1.3% yields, respectively. On the other hand, the trans-isomer (TAMP) was elaborated via double asymmetric induction, i.e. organocatalytic asymmetric cyclopropanation on chiral substrate. Thus, starting from l- and d-menthyl acrylate, in combination with quinidine-derived and quinine-derived organocatalysts, (−)- and (+)-TAMP·HCl were synthesized in total 6.6% and 3.7% yields, respectively, over 8 steps each. Configurational analysis of the synthetic intermediates based on 13C NMR is also reported. Preliminary oncological assays showed the weak but specific activities of CAMP and TAMP as the molecular basis of GABA analogs, which are still left unexplored.
Microbiota profiling with long amplicons using Nanopore sequencing: full-length 16S rRNA gene and the 16S-ITS-23S of the rrn operon
Authors: Cuscó Anna , Catozzi Carlotta , Viñes Joaquim , Sanchez Armand , Francino Olga 
Published: August 2019

Background: Profiling the microbiome of low-biomass samples is challenging for metagenomics since these samples are prone to contain DNA from other sources (e.g. host or environment). The usual approach is sequencing short regions of the 16S rRNA gene, which fails to assign taxonomy to genus and species level. To achieve an increased taxonomic resolution, we aim to develop long-amplicon PCR-based approaches using Nanopore sequencing. We assessed two different genetic markers: the full-length 16S rRNA (~1,500 bp) and the 16S-ITS-23S region from the rrn operon (4,300 bp). Methods: We sequenced a clinical isolate of Staphylococcus pseudintermedius, two mock communities and two pools of low-biomass samples (dog skin). Nanopore sequencing was performed on MinION™ using the 1D PCR barcoding kit. Sequences were pre-processed, and data were analyzed using EPI2ME or Minimap2 with rrn database. Consensus sequences of the 16S-ITS-23S genetic marker were obtained using canu. Results: The full-length 16S rRNA and the 16S-ITS-23S region of the rrn operon were used to retrieve the microbiota composition of the samples at the genus and species level. For the Staphylococcus pseudintermedius isolate, the amplicons were assigned to the correct bacterial species in ~98% of the cases with the16S-ITS-23S genetic marker, and in ~68%, with the 16S rRNA gene when using EPI2ME. Using mock communities, we found that the full-length 16S rRNA gene represented better the abundances of a microbial community; whereas, 16S-ITS-23S obtained better resolution at the species level. Finally, we characterized low-biomass skin microbiota samples and detected species with an environmental origin. Conclusions: Both full-length 16S rRNA and the 16S-ITS-23S of the rrn operon retrieved the microbiota composition of simple and complex microbial communities, even from the low-biomass samples such as dog skin. For an increased resolution at the species level, targeting the 16S-ITS-23S of the rrn operon would be the best choice.
How Do Sales Efforts Pay Off? Dynamic Panel Data Analysis in the Nerlove–Arrow Framework
Authors: Chung Doug J. , Kim Byungyeon , Park Byoung G. 
Published: August 2019

This paper evaluates the short- and long-term value of sales representatives’ detailing visits to different types of physicians. By understanding the dynamic effect of sales calls across heterogeneous physicians, we provide guidance on the design of optimal call patterns for route sales. The findings reveal that the long-term persistence effect of detailing is more pronounced for specialist physicians, whereas the contemporaneous marginal effect is higher for generalists. The paper also provides a key methodological insight to the marketing and economics literature. In the Nerlove–Arrow framework, moment conditions that are typically used in conventional dynamic panel data methods become vulnerable to serial correlation in the error structure. We discuss the associated biases and present a robust set of moment conditions for both lagged dependent and predetermined explanatory variables. Furthermore, we show that conventional tests to detect serial correlation have weak power, resulting in the misuse of moment conditions that leads to incorrect inference. Theoretical illustrations and Monte Carlo simulations are provided for validation. This paper was accepted by Matthew Shum, marketing
Data-Driven Appointment-Scheduling Under Uncertainty: The Case of an Infusion Unit in a Cancer Center
Authors: Mandelbaum Avishai , Momčilović Petar , Trichakis Nikolaos , Kadish Sarah , Leib Ryan , Bunnell Craig A. 
Published: August 2019

Service systems are often stochastic and preplanned by appointments, yet implementations of their appointment systems are prevalently deterministic. At the planning stage of healthcare services, for example, customer punctuality and service durations are often assumed equal their means—and this gap, between planned and reality, motivated our research. Specifically, we consider appointment scheduling and sequencing under a time-varying number of servers, in a data-rich environment where service durations and punctuality are uncertain. Our data-driven approach, based on infinite-server queues, yields tractable and scalable solutions that accommodate hundreds of jobs and servers. We successfully test our approach against near-optimal algorithms (which exist for merely single-servers). This entails the development of a data-driven robust optimization approach with novel uncertainty sets. To test for practical performance, we leverage a unique data set from a cancer center that combines real-time locations, electronic health records, and appointments log. Focusing on one of the center’s infusion units (roughly 90 daily appointments, 25+ infusion chairs), we reduce cost (waiting plus overtime) on the order of 15%–40% consistently, under a wide range of experimental setups.This paper was accepted by Assaf Zeevi, stochastic models and simulation.
Whistle Blowing, Forced CEO Turnover, and Misconduct: The Role of Socially Minded Employees and Directors
Authors: Bereskin Frederick , Campbell Terry , Kedia Simi 
Published: August 2019

We examine the response of prosocial employees and boards of directors to corporate misconduct. We develop several proxies for the presence of prosocial employees and directors based on the density of social networks and social capital in the county of the firms’ headquarters and companies’ relevant corporate social responsibility ratings. We document that proxies for prosocial employees and directors are associated with an increase in whistle blowing and forced chief executive officer turnover in a sample of firms that engage in misconduct. The higher expected cost of misconduct in firms with prosocial employees is associated with a lower likelihood of misconduct. Our findings highlight the role of nonfinancial imperatives of employees and directors in mitigating misconduct. This paper was accepted by Suraj Srinivasan, accounting.
Sharing the decision about VBAC: introducing the ARCS-V motivational learning model
Authors: Stockdale Janine , Lawther Lorna , McKenna Jennifer , O'Neill Deirdre 
Published: August 2019

Shared decision-making is considered key to influencing women's motivation to choose vaginal birth after caesarean section (VBAC), as when women's self-determination is respected, they are more likely to avoid intervention. However, the shared decision-making conversation can be challenging.This article introduces the ARCS-V (attention, relevance, confidence, satisfaction, volition), an model for understanding and responding to women's motivation to share the decision about VBAC vs repeat caesarean section. Each of the model's components are introduced, including the psychological basis for managing a shared conversation; capturing and holding women's attention on what they need to learn; matching the learning goals with women's personal goals; building their confidence to achieve their optimal birth; and ensuring they are satisfied with decision-making experience. When these educational conditions are met, women are more likely to use shared decision-making conversations to choose optimally.
Acute Myelogenous Leukemia as a Rare Cause of Duodenal Ulcers
Authors: Sobotka Lindsay A. , Crilley Tessa , Levine Edward , Afzali Anita 
Published: August 2019

ABSTRACT
Acute myelogenous leukemia (AML) is the most prevalent acute leukemia and is defined by the presence of myeloid blasts in the blood or bone marrow. Rarely, AML can be present in the gastrointestinal tract. We present a patient with AML undergoing treatment with decitabine who presented with hematemesis. He underwent endoscopy which revealed two 5 mm duodenal ulcers that were biopsied, and pathology was consistent with AML. Endoscopy should be considered in patients with leukemia who present with nausea, vomiting, or signs of bleeding to evaluate for gastrointestinal involvement. Patients diagnosed with AML are treated with chemotherapy.
Certain fractional kinetic equations involving generalized K-functions
Authors: Agarwal Garima , Nisar Kottakkaran Sooppy 
Published: August 2019

Abstract
The main aim of this paper is to investigate the solution of generalized fractional kinetic equations involving the

{{}_{m}{R}_{n}}

function by using the Laplace transform.
Also, we use the differential property of

{{}_{m}{R}_{n}}

to solve kinetic equations.
The obtained results are expressed in terms of generalized K-functions.
The graphical interpretations of the solutions are also presented in this study.
Modified surgical technique in an unusual uterine rupture
Authors: Vujić Goran , Radošević Velena , Matak Luka , Mikuš Mislav , Orešković Slavko 
Published: August 2019

Abstract

Background
Uterine rupture is an extremely rare and unpredictable event for women undergoing trial of labor after cesarean delivery (TOLAC).

Case presentation
We present a patient with a lateral edge uterine rupture after TOLAC and our modified surgical technique for preventing complications of uterine atony.

Conclusion
Further case report studies are required in order to evaluate the effectiveness of our new-modified surgical technique in appropriate selected cases.
Analysis of occupational accidents in the construction industry with regards to selected time parameters
Authors: Szóstak Mariusz 
Published: August 2019

Abstract
The construction industry is characterized by a large variety and variability of implementation conditions. Construction works are carried out throughout the whole calendar year under varying atmospheric conditions, both during the day and also during the evening and night. Construction workers also often work overtime that exceeds the eight-hour working day. Work in such conditions creates a particularly high threat to the health and life of working people. In the issues of work safety the most important is worker, who in the accident process has a triple role: the decision maker, the perpetrator of an accident and the victim. The purpose of this article is to examine whether there is a dependence between the number of occupational accidents in the construction industry and time parameters such as: the time of an accident, the day of the week and the month in which an accident occurred. The article also attempts to determine the dependence between the age of the injured person, work experience and the number of hours worked by the injured person from the time of starting work to the moment of the accident.
Volume Optimization of Solid Waste Landfill Using Voronoi Diagram Geometry
Authors: Koźniewski Edwin , Orłowski Marcin 
Published: August 2019

Abstract
The loose material, falling freely on the flat area, creates a geometric object similar to the roof. This object, which is in fact an embankment, the authors described and examined in previous works. They stated that the top view of such an object is a flat diagram of Voronoi. In view of the need to enlarge the landfill by combining the existing disjoint embankments, the authors were encouraged to apply the results obtained in practice. They also provided a detailed methodology for creating such embankments. In particular, they used the standard version of AutoCAD software and built a 3D model of the landfill based on solid operations. This parametric approach to design enables the rapid determination of the volume and surface area and fits in the BIM technology of designing engineering objects.