bluuebunny/crossref_metadata_2025_split huggingface dataset:
Arylsulfonamide 64B Inhibits Hypoxia/HIF-Induced Expression of c-Met and CXCR4 and Reduces Primary Tumor Growth and Metastasis of Uveal Melanoma
Authors: Dong Lei , You Shuo , Zhang Qing , Osuka Satoru , Devi Narra S. , Kaluz Stefan , Ferguson Jalisa H. , Yang Hua , Chen Guoliang , Wang Binghe , Grossniklaus Hans E. , Van Meir Erwin G. 
Published: December 2018

Abstract

Purpose:
Uveal melanoma (UM) is the most prevalent and lethal intraocular malignancy in adults. Here, we examined the importance of hypoxia in UM growth and tested the antitumor effects of arylsulfonamide 64B, an inhibitor of the hypoxia-induced factor (HIF) pathway in animal models of UM and investigated the related mechanisms.

Experimental Design:
UM cells were implanted in the uvea of mice eyes and mice systemically treated with 64B. Drug effect on primary eye tumor growth, circulating tumor cells, metastasis formation in liver, and survival were examined. 64B effects on UM cell growth, invasion and hypoxia-induced expression of C-X-C chemokine receptor type 4 (CXCR4) and mesenchymal–epithelial transition factor (c-Met) were measured. Luciferase reporter assays, chromatin immunoprecipitation, co-immunoprecipitation, and cellular thermal shift assays were used to determine how 64B interferes with the HIF transcriptional complex.

Results:
Systemic administration of 64B had potent antitumor effects against UM in several orthotopic mouse models, suppressing UM growth in the eye (∼70% reduction) and spontaneous liver metastasis (∼50% reduction), and extending mice survival (P &lt; 0.001) while being well tolerated. 64B inhibited hypoxia-induced expression of CXCR4 and c-Met, 2 key drivers of tumor invasion and metastasis. 64B disrupted the HIF-1 complex by interfering with HIF-1α binding to p300/CBP co-factors, thus reducing p300 recruitment to the MET and CXCR4 gene promoters. 64B could thermostabilize p300, supporting direct 64B binding to p300.

Conclusions:
Our preclinical efficacy studies support the further optimization of the 64B chemical scaffold toward a clinical candidate for the treatment of UM.
Proteomic Analysis of the Myocardium in Hypertrophic Obstructive Cardiomyopathy
Authors: Coats Caroline J. , Heywood Wendy E. , Virasami Alex , Ashrafi Nadia , Syrris Petros , dos Remedios Cris , Treibel Thomas A. , Moon James C. , Lopes Luis R. , McGregor Christopher G.A. , Ashworth Michael , Sebire Neil J. , McKenna William J. , Mills Kevin , Elliott Perry M. 
Published: December 2018

Background:
Hypertrophic cardiomyopathy (HCM) is characterized by a complex phenotype that is only partly explained by the biological effects of individual genetic variants. The aim of this study was to use proteomic analysis of myocardial tissue to explore the postgenomic phenotype.

Methods:
Label-free proteomic analysis was used initially to compare protein profiles in myocardial samples from 11 patients with HCM undergoing surgical myectomy with control samples from 6 healthy unused donor hearts. Differentially expressed proteins of interest were validated in myocardial samples from 65 unrelated individuals (HCM [n=51], controls [n=7], and aortic stenosis [n=7]) by the development and use of targeted multiple reaction monitoring-based triple quadrupole mass spectrometry.

Results:

In this exploratory study, 1586 proteins were identified with 151 proteins differentially expressed in HCM samples compared with controls (
P
<0.05). Protein expression profiling showed that many proteins identified in the initial discovery study were associated with metabolism, muscle contraction, calcium regulation, and oxidative stress. Proteins downregulated in HCM versus controls included creatine kinase M-type, fructose-bisphosphate aldolase A, and phosphoglycerate mutase (
P
<0.001). Proteins upregulated in HCM included lumican, carbonic anhydrase 3, desmin, α-actin skeletal, and FHL1 (four and a half LIM domain protein 1;
P
<0.01). Myocardial lumican concentration correlated with the left atrial area (ρ=0.34,
P
=0.015), late gadolinium enhancement on cardiac magnetic resonance imaging (
P
=0.03) and the presence of a pathogenic sarcomere mutation (
P
=0.04).

Conclusions:
The myocardial proteome of HCM provides supporting evidence for dysregulation of metabolic and structural proteins. The finding that lumican is raised in HCM hearts provides insight into the myocardial fibrosis that characterizes this disease.
Distal Neo-Neck Formation for Chronic Type B Dissection: False Lumen Closure After TEVAR
Authors: Furui Masato , Sakaguchi Shoji , Kakii Bunpachi , Uchino Gaku , Asanuma Mai , Nishioka Hiroaki , Yoshida Takeshi 
Published: December 2018

Objectives: Patients with chronic aortic dissection often require repeat interventions due to enlargement of the pressurized false lumen or disseminated intravascular coagulation even after additional thoracic endovascular aortic repair (TEVAR) to occlude the entry tear. Residual false lumen flow can persist even after performing the candy-plug technique or branched stent-graft placement in some cases. We have devised a new method for false lumen closure. Methods: From December 2010 to May 2017, 5 patients (mean age: 57 [13] years, range: 43-77 years) with chronic dissection at the aortic arch and descending aorta, who underwent initial TEVAR, required additional treatment. Using an open surgical approach, the endograft was fixed with an outer felt under cardiopulmonary bypass after the endograft with stent was expanded by fenestration. The false lumen was closed using this procedure, and the aortotomy was repaired by direct closure in 2 cases and by graft replacement in 3 cases. Results: No major operative complications occurred, such as respiratory failure or paraplegia. Postoperative enhanced computed tomography (CT) images showed that the false lumen flow disappeared in all cases. All patients were discharged under normal conditions. They were all followed up and their CT did not indicate any complications for a mean of 33.6 (20.3) months. Conclusions: Our combined procedure was effective and provided a higher success rate compared with endovascular therapy alone. This staged treatment approach, using a combination of TEVAR and false lumen closure, is less invasive compared with open surgery alone and may represent a valid treatment option for chronic type B dissection.
Emergency Nurses’ Perceived Confidence in Participating in the Discharge Process of Congestive Heart Failure Patients From the Emergency Department: A Quantitative Study
Authors: Sepulveda-Pacsi Alsacia L. 
Published: December 2018

Introduction: Adults with exacerbated heart failure (HF) who present to the emergency department (ED) generally are readmitted. However, Hispanic HF patients are more likely to be admitted than Whites. Studies show the importance of nurse-led interventions in the ED discharge process, but registered nurse (RN) confidence in performing discharge tasks has not been assessed. Greater nurse confidence leads to improved task performance, and potentially reduced HF readmission, lowering cost of care. This study aimed to gain insight into ED RNs’ perceived self-confidence in discharge tasks with stabilized HF patients. Method: A self-report survey on perceived self-confidence was analyzed in a prospective, cross-sectional quantitative study. Participants were 22 RNs at an ED in a largely Hispanic community in New York City. Results: Moderate levels of confidence were found for performing various tasks with HF patients. Only 6 of the 21 nurses reported feeling “very confident” about discharge tasks. Twenty (90.1%) believed guidelines would increase their confidence. Conclusion: These findings can help in developing nurse-driven strategies to foster confidence in the discharge of stabilized HF patients from the ED.
Performance and stability of the double absorbing boundary method for acoustic-wave propagation
Authors: Potter Toby , Shragge Jeffrey , Lumley David 
Published: December 2018

The double absorbing boundary (DAB) is a novel extension to the family of high-order absorbing boundary condition operators. It uses auxiliary variables in a boundary layer to set up cancellation waves that suppress wavefield energy at the computational-domain boundary. In contrast to the perfectly matched layer (PML), the DAB makes no assumptions about the incoming wavefield and can be implemented with a boundary layer as thin as three computational grid-point cells. Our implementation incorporates the DAB into the boundary cell layer of high-order finite-difference (FD) techniques, thus avoiding the need to specify a padding region within the computational domain. We tested the DAB by propagating acoustic waves through homogeneous and heterogeneous 3D earth models. Measurements of the spectral response of energy reflected from the DAB indicate that it reflects approximately 10–15 dB less energy for heterogeneous models than a convolutional PML of the same computational memory complexity. The same measurements also indicate that a DAB boundary layer implemented with second-order FD operators couples well with higher-order FD operators in the computational domain. Long-term stability tests find that the DAB and CPML methods are stable for the acoustic-wave equation. The DAB has promise as a robust and memory-efficient absorbing boundary for 3D seismic imaging and inversion applications as well as other wave-equation applications in applied physics.
Arbitragem administrativa e consensualidade: análise pontual do novo paradigma da ação administrativa
Authors: Valle Vivian Lima López 
Published: December 2018

Administrative arbitration and consensuality: punctual analysis of the new paradigm of administrative action A contratualização da ação administrativa propicia um ambiente de paridade e consensualidade administrativa. Nesse contexto a arbitragem administrativa é analisada como instrumento de negociação para resolução de conflitos na relação jurídico-administrativa contemporânea. A análise parte da premissa de que a arbitragem é instrumento de estabilidade das relações jurídico-administrativas, com enfrentamento de aspectos importantes, como cláusula arbitral vazia, a definição do conteúdo arbitrável e disponível, e da patrimonialidade e disponibilidade no ambiente de transação administrativa. Sustenta-se que a publicidade da decisão arbitral não fere o princípio da confidencialidade e que há inadequação na realização de licitação para escolha de árbitros e da Câmara de Arbitragem. The contractualization of administrative action provides an environment of parity and administrative consensus. In this context, administrative arbitration is analyzed as a negotiation tool for conflict resolution in the contemporary administrative juridical relationship. The analysis starts from the premise that arbitration is an instrument of stability of administrative legal relationships, confronting important aspects such as empty arbitration clause, definition of arbitrable and available content, and patrimoniality and availability in the administrative transaction environment. It is maintained that the publicity of the arbitration decision does not violate the principle of confidentiality and that there is inadequacy in the bidding process for the selection of arbitrators and the Arbitration Chamber.
Intra-canal medication containing silver nanoparticle versus calcium hydroxide in reducing postoperative pain: A randomized clinical trial
Authors: El Abbasy Fatma El Zahraa , Ibrahim Salsabyl , Shaker Olfat , Ahmed Geraldine 
Published: December 2018

Background:Pain of endodontic origin can be annoying for patients and endodontist. Pain relief is more important to the patient than treatment success. Numerous factors such as over instrumentation, over filling, debris extrusion can cause postoperative pain. However, bacteria found in the root canal space is the most important factor. Therefore mechanical preparation is an important step in elimination of micro-organisms from the root canal. It has been reported that micro-organisms can still survive inside the root canal even after mechanical preparation. Hence, the use of intra-canal medicaments in between visits for reduction of bacteria inside the root canal space has been recommended. The aim of this study was to assess the ability of silver nanoparticles versus calcium hydroxide used as intra-canal medication in reducing pain in necrotic teeth with apical periodontitis.Methods:Thirty-four participants were randomly divided into 2 groups, 17 in each group according to intra-canal medication used silver nanoparticles and calcium hydroxide (AgNPs and Ca(OH)2). Each patient was given pain scale chart numerical rating scale (NRS) in order to record his/her pain level before any intervention followed by placement of intra-canal medicament for 1 week. Postoperative pain was recorded at 4, 12, 24, 48 hours.Results:Pre-operatively; there was no statistically significant difference between mean pain scores in the two groups. After 4, 12 as well as 24 hours, Ca(OH)2 group showed statistically significantly higher mean pain score than AgNPs group. After 48 hours; there was no statistically significant difference between mean pain scores in the two groups.Conclusions:There was a statistically significant difference in postoperative pain following 4, 12, and 24 hours where AgNPs group resulted in reduction of pain more than Ca(OH)2 group. At 48 hours, there was no statistically significant difference.Trial registration: PACTRPACTR20160200144418026/01/2016
Tindakan Korupsi sebagai Tindakan Imoral dalam Perspektif Fungsional (Kajian Film Korupsi dan Kita: Rumah Perkara)
Authors: Muryanti Muryanti 
Published: December 2018

Abstrak. Perilaku korupsi dalam perspektif fungsionalisme structural berfungsi sebagai pelumas birokrasi untuk mempercepat sistem birokrasi menjalankan tugasnya. Korupsi merupakan salah satu fungsi melekat dalam fungsi politik dan fungsi ekonomi yang berjalan beriringan untuk memperoleh keuntungan maksimal. Tulisan ini bertujuan untuk mengetahui fungsi positif dari korupsi pada sistem politik di film: Korupsi dan Kita: Rumah Perkara. Film ini merupakan salah satu cermin situasi perpolitikan di Indonesia yang sangat rentan dengan perilaku dan tindak pidana korupsi. Metode penelitian adalah kualitatif dengan menganalisis data sekunder film dan menganalisisnya dengan perspektif structural fungsional. Hasil penelitian menunjukan bahwa fungsi positif dari korupsi benar-benar dijalankan oleh pebisnis untuk mendapatkan keuntungan dari bisnisnya tanpa mempertimbangkan moral dan mengabaikan moral itu sendiri. Perilaku bisnis bekerjasama dengan pejabat dengan melakukan suap untuk menggoalkan tujuannya. Kedua belah pihak sama-sama mendapatkan keuntungan maksimal karena kepentingan bisnis dan politik bisa berjalan beriringan. Sisi yang lain, masyarakat banyak menderita karena perilaku korupsi, diantaranya: kehilangan lahan, pekerjaan dan tanah kelahiran. Kata Kunci: Tindakan Korupsi, Imoral, Amoral dan Struktural Fungsional Abstract. Corrupt behaviour, in the perspective of structural functionalism, function as the lubricant of bureaucracy to quicken the bureaucracy system in doing their job. Corruption does have political function as well as economical client which runs simultaneously to gain maximum advantage. This writing is aimed to discover the positive function of corruptionin the political system in the movie Korupsidan Kita: RumahPerkara. This movie is one example of political situation in Indonesia which is very vulnerable to corruption. The research method is qualitative by analysing secondary data, which is movie, with structural and functional perspective. The result of the research shows that the positive function of corruption is really done by the businessman to gain advantage towards their business but with ignoring the moral value. In reaching the goal, businessman cooperate with government officers. The two parties get the advantages because business and political importance can actually run together. In the other side, society suffer from this corruption activity for example: losing land, occupation and birthplace.Keywords: corruption, immoral, structural and functional
Signs of the Times – A Historical Radio Feature
Authors: Etges Andreas , Perl Sophie 
Published: December 2018

Abstract
The article discusses ZeitZeichen, an immensely successful 15-minute radio feature that focuses on a certain date in history and is aired daily on German public radio. Using a concrete example, the authors show how ZeitZeichen can be used as a model for productions by local radio stations or as a student assignment in public history programs.
The Training of Highly Skilled Basketball Players and its Evaluation: The Context of a Microstructure
Authors: Norkus Stanislovas , Grabauskas Arūnas 
Published: December 2018

Abstract
The search for methods of optimisation of the training of highly skilled basketball players is very relevant due to an increased volume of competition activities. It is important for trainers to properly distribute training loads throughout micro-cycles and, thus, strive for more rapid regeneration, accumulation of physical and psychic efficiency of athletes. Appropriate distribution of training loads in a micro-cycle is related to reception of athletes’ feedback, too.Another highly relevant problem deals with athletes’ endeavours to develop their capacities through individual training. An athlete should be able to assess efficiency of this activity, too. The research objective is to investigate the change of highly skilled basketball players’ training loads (training conducted by trainers, additional individual training and competition activities) and the evaluation of them throughout training micro-cycles. The research methods of theoretical analysis and generalisation, observation, evaluation, mathematical statistics are applied. A fragment of an initial part of the basketball players’ training and competitions period (20 initial micro-cycles of the season 2014 – 2015) of “Šiauliai” basketball team was observed and analysed. An experienced basketball player evaluated the load undergone by the team as well as his own individual training load. Optimal sports training should be based on analysis of three activities: the training conducted by trainers, additional individual training of an athlete, athletes’ competition activities. An average duration of a sports training micro-cycle is 88.6min. The training conducted by trainers constitutes 73.1%, athlete’s additional individual training constitutes 6.0%, and the competing constitutes 20.9% of the total sports training. A major criterion of the tasks being solved throughout micro-cycles and their filling with the content are matches and the amount of them in one micro-cycle. An average evaluation of the volume of the training conducted by trainers throughout a cycle was 6.2±0.70 points; evaluation of intensity was 7.0±0.51 points. The change of evaluation of the work load, intensity throughout the micro-cycles was similar. Highly skilled basketball players do not pay appropriate attention to additional individual activities.
New data on the bats (Chiroptera) of Martinique island (Lesser Antilles), with an emphasis on sexual dimorphism and sex ratios
Authors: Catzeflis François , Issartel Gérard , Jemin Julien 
Published: December 2018

AbstractFor deciphering the biodiversity of native mammals on the island of Martinique (Lesser Antilles), bats (Chiroptera) were netted in various localities during the course of two separate studies spanning 2004–2015. A total of 2613 individuals were caught in ground-level mist nets at 79 localities. In this study, we concentrate on 1859 captures of nine species of bats caught at 24 capture-rich localities. We provide sex-ratio values, forearm and body weight measurements for each taxon. The order of decreasing abundance in captures wasArtibeus jamaicensis,Sturnira angeli,Brachyphylla cavernarum,Monophyllus plethodon,Myotis martiniquensis,Molossus molossus,Ardops nichollsi,Pteronotus davyiandTadarida brasiliensis. Our results suggest a strong sex-bias in capture rates, with males much more abundant forArdopsandMonophyllus, whereas females are more abundant forMolossus,PteronotusandSturnira. A clear sexual dimorphism exists with larger females inArdopsandPteronotus, whereas males are larger inMolossus,MonophyllusandSturnira. Reproductive females (pregnant, lactating) were found almost exclusively during the dry season (January to June) forA. jamaicensis,M. plethodonandS. angeli.
The Dveri Movement Through a Discursive Lens. Serbia’s Contemporary Right-Wing Nationalism
Authors: Jovanović Srđan Mladenov 
Published: December 2018

Abstract
Twenty-first century Serbian nationalism has had little serious analysis. Most works concentrate heavily on the nineties and the wars of Yugoslav secession, which produced a wide variety of rampant forms of nationalism throughout former Yugoslavia. Since 5 October 2000, right-wingers have somewhat softened their line in public discourse and lost some of their popular appeal, but strong nationalist tendencies have remained, taking their place in Serbia’s social and political discourses. These tendencies have been concentrated around certain extreme right-wing groups, chief among them Dveri srpske, which has been active since the early nineties. After organizing itself politically, this movement has refurbished its image and discourse, and, in the April 2016 elections, has even succeeded in entering parliament. Here, the author analyses Dveri’s agenda and key convictions: antisemitism, an anti-EU stance, support for Putin’s Russia, clericalism, and homophobia. He also reviews Dveri’s change of image and discourse over time.
Citizenship, Ethnicity, History, Nation, Region, and the Prespa Agreement of June 2018 between Macedonia and Greece
Authors: Rohdewald Stefan 
Published: December 2018

Abstract
The agreement reached at Lake Prespa on 17 June 2018 between Greece and Macedonia should be welcomed, insofar as it promises to end the Greek blockade—in any case unnecessary—of Macedonia’s accession to the European Union and to NATO. Yet conceptually, the author argues, the agreement’s text is explosive, having been crafted to fundamentally confirm and consolidate a radical ‘otherness’ of the two parties involved (that is, Greece and Macedonia), encompassing their populations and histories. Any expert tasked with supervising the re-writing of history textbooks in the spirit of this agreement, as stipulated therein, will quickly find it impossible to reconcile the definitions and concepts put forth there with the methodological and theoretical knowledge about the need to de-essentialize and de-construct ‘ethnicity’, ‘history’, ‘culture’, ‘nation’, etc. This knowledge has been the basic standard in international scholarly debates over at least the last thirty years.
A FESTA DA PENHA E O SAMBA: PATRIMÔNIOS DO RIO DE JANEIRO
Authors: Do Carmo Ricardo , Bicalho Eduardo Barbuto , Geralda de Miranda Maria 
Published: December 2018

Este artigo aborda a importância do samba como elemento de consolidação da Festa da Penha, que já foi a segunda maior festa popular do Rio de Janeiro, Brasil, perdendo apenas para o carnaval. Discute, na esteira das teorizações sobre desenvolvimento local, a existência de uma rede de solidariedade que transformariam as celebrações à padroeira Nossa Senhora da Penha em um acontecimento, em torno do qual se organizavam médios e pequenos negócios. A “mola propulsora” do evento era o samba, que criava vínculos e aproximava pessoas. A Festa, motivada pela devoção e ornamentada pelo samba, era espaço de renovação da força comunitária. Por fim, o artigo trata da importância do material simbólico-cultural da área da Penha, que ficou um longo período sob o imperativo da violência, mas que hoje volta a se desenvolver.