bluuebunny/crossref_metadata_2025_split huggingface dataset:
Viver e escrever: história e educação no acervo de cadernos de um professor catarinense (século XX)
Authors: Cunha Maria Teresa Santos , Souza Flavia de Freitas 
Published: July 2018

Este estudo tem como material empírico o conjunto de 45 cadernos pessoais deixados pelo professor e intelectual catarinense, Victor Márcio Konder (1920 – 2005), antigo docente da Universidade do Estado de Santa Catarina (UDESC, 1980) que também atuou nas fileiras do Partido Comunista Brasileiro (PCB) nos anos de 1935 a 1956, sendo estes doação póstuma de sua família ocorrida, no ano de 2009, ao acervo do Laboratório de Patrimônio Cultural (LABPAC – UDESC). Analisados como registros de uma trajetória, esses manuscritos contêm indícios sobre a formação, interesses de leitura, hábitos de escrita e formas de relacionar-se com o conhecimento que configuraram esse intelectual, professor nas décadas de 60 a 80 do século XX. Além de possibilitar o mapeamento de alguns aspectos da vida do proprietário o estudo também destaca os vários sentidos dos cadernos: como escritas ordinárias; testemunhas de uma construção de si; relíquias conectadas com uma sensibilidade nostálgica e como uma coleção a ser arquivada como objeto e patrimônio da cultura material da escola.
De cine, profesores y escuelas. Una propuesta multicultural sobre la exclusión social.
Authors: Malheiro Gutiérrez Xosé M. 
Published: July 2018

Desde la oralidad a la imagen en movimiento, el ser humano ha intentado dar respuesta a su necesidad innata de expresión. El cine ha canalizado esa necesidad y desde su nacimiento representa una fuente documental imprescindible para observar los cambios sociales; por eso supone una herramienta didáctica de primer orden al permitirnos analizar valores, ideas, actitudes o comportamientos en diversos ámbitos profesionales. Y en ese sentido, nos aporta información relevante sobre la problemática educativa a través de sus diferentes agentes en múltiples contextos culturales y geográficos. El trabajo que se presenta centra su atención en el relato de la exclusión social en el contexto escolar tomando como referencia diez películas de este comienzo de siglo.
Histórias e Centros de Memórias da Educação Profissional: instituições, sujeitos, práticas e currículos
Authors: Kamensky Andrea Paula dos Santos Oliveira , Ribeiro Suzana Lopes Salgado 
Published: July 2018

Coleções, acervos e centros de memória: memórias e história da educação profissional é o terceiro livro da coleção Memórias e história da educação profissional. Ao ser publicado concretiza mais um passo no importante caminho da sistematização de trabalhos que vem sendo feita há tempos por professores do Grupo de Estudos e Pesquisas em Memórias e História da Educação Profissional (GEPEMHEP), do Centro Paula Souza – atuante na educação profissional do Estado de São Paulo.
Analisis Resepsi Pejabat Publik terhadap Program Update Pagi SBO TV
Authors: Sari Ardiani Kusuma , Hariyanto Didik 
Published: July 2018

This study aims to describe the reception of public officials on Update Pagi SBO TV program. This research using qualitative method. Informants in this study are public officials who come from government or non government in Surabaya. The data collected by indepth interviews, observation and documentation. Data analysis techniques used Miles and Huberman models. The results of the study shows that the Update Pagi program is considered important and effective, it is helpful in providing information from stakeholders to the public, and has contributed to delivering new policies or problem solving with a direct dialogue strategy between the community and the government or parties related themes discussed in Update Pagi SBO TV Program.
Komunikasi Interpersonal Guru dan Murid Anak Berkebutuhan Khusus (ABK) dalam Kegiatan Belajar Mengajar Kelas Inklusif SMA Negeri 1 Gedangan
Authors: Duha Yanwar Abi , Aesthetika Nur Maghfirah 
Published: July 2018

This study aimed to determine how interpersonal communication between teacher and children with special needs in learning activities inclusive class at senior high school 1 Gedangan. This study used descriptive qualitative method by in-depth interview and observation. Data analysis technique used analytic descriptive method which included collection and composing of data analysis. The result of this study was the teacher in Senior High School 1 Gedangan had done five general quality process into the value of effectiveness interpersonal communication through the way they communicate in the learning process. However, not all of these indicators could be implemented in the type of direct communication. Empathy in the interpersonal communication manifested into the type of giving method in order to facilitate understanding that done by children with special needs. In addition, interpersonal communication through openness process in resolving problem that involve children with special needs and supportiveness through curriculum and method implementation, different implementation between children with special needs and regurel students.
Analisis Wacana Makrostruktural Pemberitaan Ahok pada Pilkada DKI Jakarta 2017
Authors: Mandarani Vidya , Suwarta Nyoman 
Published: July 2018

This study aims to find out the news macrostructural discourse analysis of Ahok in 2017 Jakarta’s election by using critical discourse analysis. This research applies the theory and method of Norman Fairclough critical discourse analysis in macrostructural dimension. This study is a qualitative research through the literature study on the media about Ahok in the Jakarta elections in 2017. From these results it can be concluded that the macrostructural analysis can be seen that the various media collected, it can be found that related to the upcoming elections in 2017 Jakarta’s election, namely Ahok during the campaign hampered charged with blasphemy. It can be used as a political motive for the purpose of winning the elections of Jakarta through the blasphemy case. One is the size of a political desire to prop Ahok through cases of blasphemy, because Ahok not successfully tackled through various other criminal cases.
Proses Produksi Iklan Radio di LPP Radio Republik Indonesia Palu
Authors: Sari Dyah Fitria Kartika , Herman Achmad , Kaddi Sitti Murni 
Published: July 2018

This study aimed to determine types of advertising which is produced in LPP RRI Palu and its production process as well as determine supporting and inhibiting factors of radio advertising production process. The methodology used Action Research based on model characteristics, organizational structure and development goals, system design or scientific development and form of research involvement. The results showed that advertisement was produced in LPP RRI Palu was ad lib, ad spot, and sponsor program. Ad lib production process that was initial briefing, editing script, and broadcast. Ad spot was the initial briefing, creative strategy formulation, drafting, implementation, production of finished advertisement, and evaluation. While ad sponsors program was collaboration of ad spots and ad lib that aired alternately during one program of the event took place. Percentage for ad lib 50% and spot ads 50% per time of ad broadcast. Whereas the program sponsor's only has one or two even in one year there was no broadcast sponsor program. Overall ad impressions per day account for 15% of all broadcast programs.
Mapping Organization Knowledge Network and Social Media Based Reputation Management
Authors: Alamsyah Andry , Syawiluna Maribella 
Published: July 2018

Knowledge management are important aspects in an organization, especially in ICT industry. Having more control of it is essentials for the organization to stay competitive in the business. One way to assess the organization knowledge capital is by measuring employee knowledge network and their personal reputation in social media. Using this measurement, we see how employee build relationship around their peer networks or clients virtually. We also able to see how knowledge network support organization performance.
The research objective is to map knowledge network and reputation formulation in order to fully understand how knowledge flow and whether employee reputation have higher degree of influence in organization knowledge network. We particularly develop formulas to measure knowledge network and personal reputation based on their social media activities. As case study, we pick an Indonesian ICT company which actively build their business around their employee peer knowledge outside the company.
For knowledge network, we perform data collection by conducting interviews. For reputation management, we collect data from several popular social media. We base our work on Social Network Analysis (SNA) methodology. The result shows that employees knowledge is directly proportional with their reputation, but there are different reputations level on different social media observed in this research.
Features of the anemia at patients with Crohn’s disease
Authors: Akhmedov V. A. , Ivanyuk M. N. , Bikbavova G. R. , Ibragimova M. R. , Ibragimova A. R. 
Published: July 2018

One of the most frequent clinical and laboratory manifestations and complications of inflammatory bowel diseases (IBD) is anemia. In the presented review the reasons, criteria of diagnostics and therapeutic correction of various variants of anemia in Crohn’s disease are considered.
Synergistic Interplay of The Co-administration of Rifampin And Newly Developed Anti-TB Drug: Could It Be a Promising New Line of TB Therapy?
Authors: Agoni Clement , Ramharack Pritika , Soliman Mahmoud E.S. 
Published: July 2018

Background:
Rifampin resistance has dampened the existing efforts being made to
control the global crisis of Tuberculosis and antimicrobial resistance in general. Previous studies
that attempted to provide insights into the structural mechanism of Rifampin resistance did not
utilize the X-ray crystal structure of Mycobacterium tuberculosis RNA polymerase due to its
unavailability.

Methods/Results:
We provide an atomistic mechanism of Rifampin resistance in a single active site
mutating Mycobacterium tuberculosis RNA polymerase, using a recently resolved crystal structure.
We also unravel the structural interplay of this mutation upon co-binding of Rifampin with a novel
inhibitor, D-AAP1. Mutation distorted the overall conformational landscape of Mycobacterium
tuberculosis RNA polymerase, reduced binding affinity of Rifampin and shifted the overall residue
interaction network of the enzyme upon binding of only Rifampin. Interestingly, co-binding with DAAP1,
though impacted by the mutation, exhibited improved Rifampin binding interactions amidst a
distorted residue interaction network.

Conclusion:
Findings offer vital conformational dynamics and structural mechanisms of mutant
enzyme-single ligand and mutant enzyme-dual ligand interactions which could potentially shift the
current therapeutic protocol of Tuberculosis infections.
Synthesis and Characterization of Novel Organomodified Nanoclays for Application in Dental Materials
Authors: Nikolaidis Alexandros K. , Koulaouzidou Elisabeth A. , Achilias Dimitris S. 
Published: July 2018

Background:
Nanoclays incorporated in dental resins have been previously investigated.
However, limited reports are associated with nanoclays that exhibit high functionality.

Objective:
The aim of this study was the targeted synthesis and characterization of organomodified
nanoclays with methacrylic groups suitable for incorporation in dental nanocomposite resins.

Methods:
Quaternary ammonium methacrylates were synthesized and characterized by means of
proton nuclear magnetic resonance and Fourier-transform infrared spectroscopy. Consequently, they
were inserted into the interlayer space of nanoclay through a cation exchange reaction, while silane
was also used for simultaneous surface modification. The produced organomodified nanoclays were
characterized by means of X-ray diffraction, Fourier-transform infrared spectroscopy and thermogravimetric
analysis.

Results:
Fourier-transform infrared spectra confirmed the successful synthesis of the quaternary
ammonium methacrylates. X-ray diffraction analysis showed that organoclays exhibited higher d001-
values (up to 1.78 nm) compared to raw nanoclay (1.37 nm), indicating an accomplished intercalation
in each case. X-ray diffraction spectra mainly disclosed the presence of methacrylic functional
groups in all nanoclays. Thermogravimetric analysis curves verified the different thermal stability of
organoclays due to the diversity of their organic modifiers.

Conclusion:
The experimental results showed that nanoclay was successfully modified with ammonium
methacrylates and silane. Τhe combination of X-ray diffraction and thermogravimetric analysis
data revealed a high degree of intercalation and methacrylated organic loading as well. These phenomena
may favor a good dispersion and high polymerization degree of nanoclays with dental resin
monomers, rendering them potentially useful materials for the development of advanced dental
nanocomposites resins.
Kinase Phosphorylation-based Mechanisms of PARP Inhibitor Resistance During Synthetic Lethal Oncotherapy
Authors: Osaki Eriko , Mizuno Shinya 
Published: July 2018

Background:
Poly-(ADP-Ribose) Polymerase (PARP) plays a central role in recovery
from single-strand DNA (ssDNA) damage via base excision repair. When PARP activity is
inhibited by a NAD+ mimetic analog, ssDNA is converted into a Double-Strand Break (DSB)
during the S-phase in a cell cycle. However, the DSB site is repaired in a process of Homologous
Recombination (HR) that is derived by genes such as BRCA1/2, PALB2, and RAD51. Under
conditions of HR dysfunction, including mutations of BRCA1/2 (called BRCAness), PARP
inhibitor (PARPi) induces “synthetic lethality” in BRCAness-specific cancer cells. Indeed, clinical
trials using forms of PARPi that include olaparib, veliparib and rucaparib, have revealed that
PARP inhibition produces a dramatic effect that actually arrests cancer progression. Its clinical
efficiency is limited, however, due to the acquisition of PARPi resistance during long-term use of
this inhibitor. Thus, it is important to elucidate the mechanisms of PARPi resistance.

Methods:
We searched the scientific literature published in PubMed, with a special focus on
kinase phosphorylation that is involved in acquiring PARPi resistance. We also summarized the
possible molecular events for recovering HR system, a key event for acquiring PARPi resistance.

Results:
CDK1 is a critical kinase for 5’-3’ DNA end resection, which is important for generating
ssDNA for recruiting HR-priming factors. CDK12 is necessary for the transcription of HR-driver
genes, such as BRCA1, BRCA2, RAD51 and ATR via the phosphorylation of RNA Pol-II. PLK-1
participates in driving HR via the phosphorylation of RAD51. The PI3K-AKT-mTOR signaling
cascade is involved in BRCA1 induction via an ETS1 transcriptional pathway. Even under ATMdeficient
conditions, the ATR-CHK1 axis compensates for loss in the DNA damage response,
which results in HR recovery. The HGF receptor Met tyrosine kinase is responsible for promoting
DNA repair by activating the PARP catalytic domain.

Conclusion:
These kinase-based signaling pathways are biologically important for understanding
the compensatory system of HR, whereas inactivation of these kinases has shown promise for the
release of PARPi resistance. Several lines of preclinical studies have demonstrated the potential
use of kinase inhibitors to enhance PARPi sensitivity. We emphasize the clinical importance of
chemical inhibitors as adjuvant drugs to block critical kinase activities and prevent the possible
PARPi resistance.
FAIRY STORY INTEGRATION FOR MEANINGFUL CLASSROOM
Authors: Wangid Muhammad Nur , Mustadi Ali , Putri Agnestasia Ramadhani 
Published: July 2018

Abstract: The National Indonesian Ministry of Education expresses the importance of educating friendliness by stating it in a Master Plan of National Character Development for 2010-2015. However the success of character education needs a meaningful classroom situation. Unfortunately, teaching materials to create meaningful classroom situation that enhances friendliness character is still rare. Sainsmatika fairytale books are science and mathematic’s teaching material which was developed with the wisdom of fairytale, which is attractive to integrate friendliness value. The study aimed to investigate the effectiveness of sainsmatika fairytale books as a means of integrating friendliness into teaching materials for fourth-grade students in Indonesia. A pretest-posttest control-group experimental design was used in this study to investigate the product effectiveness. This study involved 80 fourth-grade students at one of the districts in Indonesia. The experimental group was taught using sainsmatika fairytale books containing one of the character values in character education, i.e., friendliness. The quantitative data were collected through observation on student activity. The data were then analyzed using statistical methods to calculate the values and determine the frequency as well as the mean of pretest and posttest scores in both control and experimental groups. Through one way ANOVA statistical analysis, it was found that the use of sainsmatika fairytale books is significantly effective to enhance the student friendliness. Kata Kunci: fairy stories, sainsmatika, friendliness character INTEGRASI CERITA DONGENG UNTUK PEMBELAJARAN BERMAKNA Abstrak: Kementerian Pendidikan Nasional Indonesia mengekspresikan pentingnya mengajarkan karakter bersahabat dengan memasukkannya ke dalam Master Plan Pengembangan Karakter Nasional 2010-2015. Keberhasilan pendidikan karakter mebutuhkan situasi pembelajaran yang bermakna. Bahan ajar untuk menciptakan situasi pembelajaran bermakna yang dapat meningkatkan karakter bersahabat masih kurang. Buku dongeng sainsmatika adalah bahan ajar sains dan matematika yang dikembangkan dengan pendekatan kearifan dongeng yang menarik untuk diintegrasikan dengan nilai karakter bersahabat. Penelitian ini bertujuan untuk untuk mengetahui keefektifan buku dongeng sainsmatika sebagai bahan ajar terhadap karakter bersahabat siswa. Penelitian menggunakan pendekatan experimental pretest-posttest control-group design. Sebanyak 80 siswa kelas 4 sekolah dasar di salah satu provinsi di Indonesia dilibatkan dalam penelitian ini. Setiap kelas eksperimen belajar menggunakan buku dongeng sainsmatika. Data dikumpulkan dengan menggunakan teknik observasi dan dianalisis dengan teknik statistik anova untuk menghitung frekuensi dan rata-rata hitung pretes dan postes baik kelas eksperimen maupun kelas kontrol. Hasil penelitian menunjukkan bahwa penggunaan buku dongeng sainsmatika mampu meningkatkan karakter bersahabat siswa secara signifikan. Keywords: dongeng, sainsmatika, karakter bersahabat
MENGENAL FILSAFAT EKSISTENSIALISME JEAN-PAUL SARTRE SERTA IMPLEMENTASINYA DALAM PENDIDIKAN
Authors: Sunarso Sunarso 
Published: July 2018

Pendidikan dan filsafat tidak dapat dipisahkan satu dengan yang lainnya. Filsafat bagi pendidikan berperan sebagai pedoman yang memberikan arahan dan tujuan pendidikan. Sedangkan pendidikan bagi filsafat merupakan suatu ‘ruang’ yang selalu memberinya tempat untuk hidup dan terus berkembang melalui kegiatan-kegiatan teoritis maupun praktis dalam pendidikan. Filsafat eksistensialisme Jean Paul Sartre dapat digunakan sebagai dasar pijakan dalam kegiatan belajar mengajar di kelas. Menurut Sartre, manusia adalah individu yang bebas. Namun kebebasan yang dimilikinya selalu terbatasi dengan fakta akan adanya kebebasan individu lain. Manusia adalah bebas untuk melakukan dan mendefinisikan dirinya sendiri secara individual. Manusia tidak lain adalah bagaimana ia menjadikan dirinya sendiri. Belajar adalah menjadikan dirinya sendiri otonom dan menyadari adanya orang lain sehingga dapat menciptakan dunianya sendiri yang berarti bagi dirinya dan bagi kehidupan orang lain atau lingkungannya. Namun demikian, kita tetap harus selektif terhadap pemikiran Sartre tentang peniadaan Tuhan. Dalam merumuskan konsep kebebasan individu, Sartre mengasumsikan bahwa tanpa bantuan Tuhan, manusia dapat bebas mendefinisikan dirinya sendiri untuk mencapai tujuan hidupnya. Pandangan ini jelas bertentangan dengan falsafah dasar negara kita yaitu Pancasila sila Ketuhanan Yang Maha Esa.
Menakar Kesejahteraan Buruh: Memperjuangkan Kesejahteraan Buruh diantara Kepentingan Negara dan Korporasi
Authors: Hendrastomo Grendi 
Published: July 2018

Artikel ini bertujuan untuk menganalisis ketimpangan antara kesejahteraan dengan peluh kerja buruh, melihat hubungan antara negara, pengusaha dan buruh, serta mengajukan solusi untuk meningkatkan kesejahteraan buruh. Kesejahteraan buruh mutlak diperjuangkan untuk lebih memanusiakan buruh. Kebijakan yang diambil negara selayaknya tidak mengorbankan kaum buruh. Isu tentang perburuhan sampai saat ini merupakan salah satu isu sexi yang sering kali dijadikan alat tawar politik maupun obyek pencitraan. Buruh menjadi komoditas jualan parpol yang disatu sisi penopang dan menjadi tulang punggung perekonomian nasional tetapi disatu sisi dipandang sebelah mata, terlihat dari kehidupan kaum buruh yang tak kunjung membaik. Desakan dari serikat pekerja maupun perundingan antara pengusaha, pemerintah dan buruh selalu berujung pada kegagalan. Outsourcing, Pemutusan hubungan kerja (PHK), Upah minimum regional (UMR), upah yang tak kunjung dibayar hingga kemiskinan yang menghinggapi kaum buruh menjadi permasalahan akut yang tak kunjung ada jalan keluarnya. Satu kesamaan diantara semua masalah, buruhlah yang harus menanggung semuanya. Peningkatan kesejahteraan menjadi dorongan buruh untuk terus berjuang. Kata kunci: Kesejahteraan, Buruh, Kemiskinan, Marginalisasi
Патогенетичні механізми та ознаки серцево-судинних уражень при цукровому діабеті 2-го типу
Authors: Shkala L.V. , Mishanich G.I. , Shkala O.V. , Cherpak O.V. , Karapetyan E.A. , Volkovskaya T.G. 
Published: July 2018

Актуальність. Висока захворюваність та поширеність цукрового діабету (ЦД) зумовлює ранню інвалідизацію та смертність через розвиток хронічних ускладнень. При цьому головна причина смерті при ЦД 2-го типу пов’язана із серцево-судинними захворюваннями. Мета дослідження: з’ясувати частоту, механізми та прояви уражень серцево-судинної системи у хворих на ЦД 2-го типу. Матеріали та методи. Обстежено 49 пацієнтів з ЦД 2-го типу віком понад 50 років, у тому числі 25 чоловіків, 24 жінки. Визначали показники метаболізму, зміни електрокардіограми. Результати. У групі спостереження у 55,1 % пацієнтів виявлена ішемічна хвороба серця (ІХС), у 77,6 % — артеріальна гіпертензія, у 28,6 % — перенесені кардіоваскулярні події. Переважали хворі (83,7 %) з надлишковою масою тіла і ожирінням. У 57,1 % виявлені порушення ліпідного обміну за наявної декомпенсації ЦД в 61,2 %, що підтверджено збільшенням рівня глікованого гемоглобіну до 8,8 ± 0,3 %. Зареєстровані порушення процесів автоматизму, збудливості та провідності серця: у 12,2 % — синусова тахікардія, у 6,1 % — синусова брадикардія, у 4,1 % — синусова аритмія, у 10,2 % — миготлива аритмія, у 8,2 % — суправентрикулярна і шлуночкова екстрасистолія, у 30,6 % — внутрішньошлуночкові блокади. Прояви гіпоксії мали 32,7 % пацієнтів, зміни зубця Q — 8,2 %, зміни інтервалу ST — 8,2 %. Висновки. Дисметаболічні порушення є підґрунтям для розвитку хронічних діабетичних ускладнень, що формують, зокрема, кардіальну автономну нейропатію, діабетичну кардіоміопатію та атеросклеротичні ураження серцево-судинної системи з маніфестацією ІХС, артеріальної гіпертензії, синдрому порушень ритму і провідності, гіпоксії.