bluuebunny/crossref_metadata_2025_split huggingface dataset:
Enhanced landslide mobility by basal liquefaction: The 2014 State Route 530 (Oso), Washington, landslide
Authors: Collins Brian D. , Reid Mark E. 
Published: June 2019

AbstractLandslide mobility can vastly amplify the consequences of slope failure. As a compelling example, the 22 March 2014 landslide near Oso, Washington (USA), was particularly devastating, traveling across a 1-km+-wide river valley, killing 43 people, destroying dozens of homes, and temporarily closing a well-traveled highway. To resolve causes for the landslide’s behavior and mobility, we conducted detailed postevent field investigations and material testing. Geologic and structure mapping revealed a progression of geomorphological structures ranging from debris-flow lobes at the distal end through hummock fields, laterally continuous landslide blocks, back-rotated blocks, and finally colluvial slides and falls at the landslide headscarp. Primary structures, as well as stratigraphic and vegetation patterns, in the landslide deposit indicated rapid extensional motion of the approximately 9 × 106 m3 source volume in a closely timed sequence of events. We identified hundreds of transient sand boils in the landslide runout zone, representing evidence of widespread elevated pore-water pressures with consequent shear-strength reduction at the base of the slide. During the event, underlying wet alluvium liquefied and allowed quasi-intact slide hummocks to extend and translate long distances across the flat valley. Most of the slide material itself did not liquefy. Using geotechnical testing and numerical modeling, we examined rapid undrained loading, shear and collapse of loose saturated alluvium, and strong ground shaking as potential liquefaction mechanisms. Our analyses show that some layers in the alluvium can liquefy when sheared, as could occur with rapid undrained loading. Simultaneous ground shaking could have contributed to pore-pressure generation as well. Two key elements, a large and rapid failure overriding wet liquefiable sediments, enabled the landslide’s high mobility. Basal liquefaction may enhance mobility of other landslides in similar settings.
Detrital zircons and sediment dispersal from the Coahuila terrane of northern Mexico into the Marathon foreland of the southern Midcontinent
Authors: Thomas William A. , Gehrels George E. , Lawton Timothy F. , Satterfield Joseph I. , Romero Mariah C. , Sundell Kurt E. 
Published: June 2019

AbstractNew analyses of U-Pb ages along with previously published analyses of detrital zircons from sandstones in the foreland of the Marathon orogen in west Texas have significant implications regarding provenance. The most prominent concentrations of U-Pb ages are at 1200–1000, 700–500, and 500–290 Ma. The accreted Coahuila terrane in the Marathon hinterland and nearby terranes with Gondwanan (Amazonia) affinity include Paleozoic volcanic and plutonic rocks, as well as Precambrian basement rocks. Late Paleozoic Las Delicias arc rocks have ages of 331–270 Ma. Detrital zircons from Upper Jurassic and Lower Cretaceous sandstones, which were deposited in local basins around the Coahuila terrane, provide a record of detritus available from proximal sources within Coahuila, including important peaks at 1040, 562, 422, 414, 373, and 282 Ma. Components of the detrital-zircon populations in the Marathon foreland have unique matches with primary and/or detrital sources in the Coahuila terrane. Although some components of the Marathon populations also have age matches in Laurentia (Appalachians), others do not; however, all components of the Marathon populations have potential sources in Coahuila. Analyses of εHft show generally more negative values in Amazonia than in Laurentia, and εHft values for Marathon sandstones have distributions similar to those in Amazonia. Therefore, the Coahuila terrane provides a provenance for all of the detrital-zircon ages in the Marathon foreland, requiring no mixing from other sources.
Impact of mobile health applications on self-management in patients with type 2 diabetes mellitus: protocol of a systematic review
Authors: Bene Benard Ayaka , O’Connor Siobhan , Mastellos Nikolaos , Majeed Azeem , Fadahunsi Kayode Philip , O’Donoghue John 
Published: June 2019

IntroductionThe emergence of mobile health (mHealth) solutions, particularly mHealth applications (apps), has shown promise in self-management of chronic diseases including type 2 diabetes mellitus (T2DM). While majority of the previous systematic reviews have focused on the effectiveness of mHealth apps in improving treatment outcomes in patients with T2DM, there is a need to also understand how mHealth apps influence self-management of T2DM. This is crucial to ensure improvement in the design and use of mHealth apps for T2DM. This protocol describes how a systematic review will be conducted to determine in which way(s) mHealth apps might impact on self-management of T2DM.MethodsThe following electronic databases will be searched from inception to April 2019: PubMed, MEDLINE, EMBASE, Global Health, PsycINFO, CINAHL, The Cochrane Central Register of Controlled Trials, Scopus, Web of Science, ProQuest Dissertations & Theses Global, Health Management Information Consortium database, Google Scholar and ClinicalTrials.gov. The Cochrane risk of bias tool will be used to assess methodological quality. The primary outcome measures to be assessed will be ‘change in blood glucose’. The secondary outcomes measures will be ‘changes in cardiovascular risk markers’ (including blood pressure, body mass index and blood lipids), and self-management practices. Others will include: health-related quality of life, economic data, social support, harms (eg, death or complications leading to hospital admissions or emergency unit attendances), death from any cause, anxiety or depression and adverse events (eg, hypoglycaemic episodes).Ethics and disseminationThis study will not involve the collection of primary data and will not require ethical approval. The review will be published in a peer-reviewed journal and a one-page summary of the findings will be shared with relevant organisations. Presentation of findings will be made at appropriate conferences.Trial registration numberCRD42017071106.
Assessing the relationship between near-infrared spectroscopy-derived regional cerebral oxygenation and neurological dysfunction in critically ill adults: a prospective observational multicentre protocol, on behalf of the Canadian Critical Care Trials Group
Authors: Wood Michael D , Khan Jasmine , Lee Kevin F H , Maslove David M , Muscedere John , Hunt Miranda , Scott Stephen H , Day Andrew , Jacobson Jill A , Ball Ian , Slessarev Marat , O’Regan Niamh , English Shane W , McCredie Victoria , Chasse Michaël , Griesdale Donald , Boyd J Gordon 
Published: June 2019

IntroductionSurvivors of critical illness frequently exhibit acute and chronic neurological complications. The underlying aetiology of this dysfunction remains unknown but may be associated with cerebral ischaemia. This study will use near-infrared spectroscopy to non-invasively quantify regional cerebral oxygenation (rSO2) to assess the association between poor rSO2during the first 72 hours of critical illness with delirium severity, as well as long-term sensorimotor and cognitive impairment among intensive care unit (ICU) survivors. Further, the physiological determinants of rSO2will be examined.Methods and analysisThis multicentre prospective observational study will consider adult patients (≥18 years old) eligible for enrolment if within 24 hours of ICU admission, they require mechanical ventilation and/or vasopressor support. For 72 hours, rSO2will be continuously recorded, while vital signs (eg, heart rate) and peripheral oxygenation saturation will be concurrently captured with data monitoring software. Arterial and central venous gases will be sampled every 12 hours for the 72 hours recording period and will include: pH, PaO2, PaCO2, and haemoglobin concentration. Participants will be screened daily for delirium with the confusion assessment method (CAM)-ICU, whereas the brief-CAM will be used on the ward. At 3 and 12 months post-ICU discharge, neurological function will be assessed with the Repeatable Battery for the Assessment of Neuropsychological Status and KINARM sensorimotor and cognitive robot-based behavioural tasks.Ethics and disseminationThe study protocol has been approved in Ontario by a central research ethics board (Clinical Trials Ontario); non-Ontario sites will obtain local ethics approval. The study will be conducted under the guidance of the Canadian Critical Care Trials Group (CCCTG) and the results of this study will be presented at national meetings of the CCCTG for internal peer review. Results will also be presented at national/international scientific conferences. On completion, the study findings will be submitted for publication in peer-reviewed journals.Trial registration numberNCT03141619
Quality of life after interventions for malignant pleural effusions: a systematic review
Authors: Sivakumar Parthipan , Saigal Anita , Ahmed Liju 
Published: June 2019

BackgroundMalignant pleural effusion (MPE) results in breathlessness and impairment of health-related quality of life (HRQOL). This study reviews the existing literature on HRQOL following invasive interventions in MPE.MethodsFive electronic databases were systematically searched and assessed three times during the review process and last completed on 15 June 2018. We included all studies evaluating HRQOL outcomes for the following interventions: therapeutic thoracocentesis, talc slurry (TS) pleurodesis, indwelling pleural catheter (IPC) insertion and thoracoscopic talc poudrage (TTP) pleurodesis. Meta-analysis was not performed due to substantial heterogeneity in the published data.Results17 studies were included in the review reporting HRQOL outcomes in 2515 patients. TTP, TS and IPC were associated with modest but inconsistent improvements in HRQOL up to 12 weeks. No intervention was significantly different from another in HRQOL outcomes at any time point. The attrition to follow-up was 48.3% (664/1374) at 3 months. The overall quality of studies was inadequate.ConclusionTTP, TS and IPC seem to improve HRQOL in MPE over 4–12 weeks, but there are insufficient longer term data due to high attrition rates. Evidence on the most effective treatment strategy is limited by the small number of randomised or comparative studies.Trial registration numberCRD42016051003.
A comparative analysis of 3MAX aspiration versus 3 mm Trevo Retriever for distal occlusion thrombectomy in acute stroke
Authors: Haussen Diogo C , Eby Brendan , Al-Bayati Alhamza R , Grossberg Jonathan A , Rodrigues Gabriel Martins , Frankel Michael R , Nogueira Raul G 
Published: June 2019

BackgroundAlthough aspiration and stent retriever thrombectomy perform similarly in proximal occlusions, no comparative series are available in distal occlusions. We aimed to compare the 3 mm Trevo Retriever against the 3MAX thromboaspiration catheter in distal arterial occlusions.MethodsA single-center retrospective review of a prospectively maintained databank for patients treated with the 3 mm Trevo stent retriever or 3MAX thromboaspiration as the upfront approach for distal occlusions (middle cerebral artery mid/distal M2/M3, anterior cerebral artery A1/A2/A3 or posterior cerebral artery P1/P2) from January 2014 to July 2018 was performed. The primary outcome was the rate of distal occlusion first-pass reperfusion (modified Thrombolysis in Cerebral Infarction (mTICI) 2b–3).ResultsOf 1100 patients treated within the study period, 137 patients/144 different arteries were treated with the 3 mm Trevo (n=92) or 3MAX device (n=52). The groups had comparable demographics and baseline characteristics. There was a higher rate of first-pass mTICI 2b–3 reperfusion (62% vs 44%; p=0.03), a trend towards a higher rate of final mTICI 2b–3 reperfusion (84% vs 69%; p=0.05), and lower use of adjuvant therapy (15% vs 31%; p=0.03) with the 3 mm Trevo compared with the 3MAX. The median number of passes (p=0.46), frequency of arterial spasm (p=1.00), rates of parenchymal hematomas (p=0.22)/subarachnoid hemorrhage (p=0.37) in the territory of the approached vessel were similar across the two groups. The 90-day rate of good outcomes (45% vs 46% in the 3 mm Trevo and 3MAX groups, respectively; p=0.84) was comparable. Multivariable regression identified baseline NIH Stroke Scale (NIHSS) score (OR 0.9; 95% CI 0.8 to 0.97; p<0.01) and use of 3 mm Trevo (OR 2.2; 95% CI 1.1 to 4.6; p=0.02) independently associated with first-pass mTICI 2b–3 reperfusion.ConclusionsIn the setting of distal arterial occlusions, the 3 mm Trevo may lead to higher rates of first-pass reperfusion than direct 3MAX thromboaspiration. Lower NIHSS was found to be associated with improved reperfusion rates as observed in more proximal lesions. Further studies are warranted.
Increased baseline ECG R-R dispersion predicts improvement in systolic function after atrial fibrillation ablation
Authors: Koene Ryan J , Buch Eric , Seo Young-Ji , Li Jian-Ming , Mbai Mackenzi , Chandrashekhar Y , Shivkumar Kalyanam , Tholakanahalli Venkatakrishna N 
Published: June 2019

BackgroundAtrial fibrillation (AF) is associated with left ventricular (LV) systolic dysfunction which may improve after AF ablation. We hypothesised that increased ventricular irregularity, as measured by R-R dispersion on the baseline ECG, would predict improvement in the left ventricular ejection fraction (LVEF) after AF ablation.MethodsPatients with LVEF <50% at two US centres (2007–2016), having both a preablation and postablation echocardiogram or cardiac MRI, were included. LVEF improvement was defined as absolute increase in LVEF by >7.5%. Multivariable logistic regression (restricted to echocardiographic/ECG variables) was performed to evaluate predictors of LVEF improvement.ResultsFifty-two patients were included in this study. LVEF improved in 30 patients (58%) and was unchanged/worsened in 22 patients (42%). Those with versus without LVEF improvement had an increased baseline R-R dispersion (645±155 ms vs 537±154 ms, p=0.02, respectively). The average baseline heart rate in all patients was 93 beats per minute. After multivariable logistic regression, increased R-R dispersion (OR 1.59, 95% CI 1.00 to 2.55, p=0.03) predicted LVEF improvement.ConclusionsIncreased R-R dispersion on ECG was independently associated with improved systolic function after AF ablation. This broadens the existing knowledge of arrhythmia-induced cardiomyopathy, demonstrating that irregular electrical activation (as measured by increased R-R dispersion on ECG) is associated with a cardiomyopathy capable of improving after AF ablation.
CORES
Authors: Wen Weidong , Li Yang , Li Wenhai , Deng Lingfeng , He Yanxiang 
Published: June 2019

The relatively high cost of record deserialization is increasingly becoming the bottleneck of column-based storage systems in tree-structured applications [58]. Due to record transformation in the storage layer, unnecessary processing costs derived from fields and rows irrelevant to queries may be very heavy in nested schemas, significantly wasting the computational resources in large-scale analytical workloads. This leads to the question of how to reduce both the deserialization and IO costs of queries with highly selective filters following arbitrary paths in a nested schema.
We present CORES (Column-Oriented Regeneration Embedding Scheme) to push highly selective filters down into column-based storage engines, where each filter consists of several filtering conditions on a field. By applying highly selective filters in the storage layer, we demonstrate that both the deserialization and IO costs could be significantly reduced. We show how to introduce fine-grained composition on filtering results. We generalize this technique by two pair-wise operations, rollup and drilldown, such that a series of conjunctive filters can effectively deliver their payloads in nested schema. The proposed methods are implemented on an open-source platform. For practical purposes, we highlight how to build a column storage engine and how to drive a query efficiently based on a cost model. We apply this design to the nested relational model especially when hierarchical entities are frequently required by ad hoc queries. The experiments, including a real workload and the modified TPCH benchmark, demonstrate that CORES improves the performance by 0.7×--26.9× compared to state-of-the-art platforms in scan-intensive workloads.
Temporal induction of intestinal epithelial hypoxia-inducible factor-2α is sufficient to drive colitis
Authors: Solanki Sumeet , Devenport Samantha N. , Ramakrishnan Sadeesh K. , Shah Yatrik M. 
Published: June 2019

Hypoxia is a notable feature of inflammatory bowel disease and chronic induction of hypoxia-inducible factor (HIF)-1α and HIF-2α (endothelial PAS domain protein 1, EPAS1) play important, but opposing, roles in its pathogenesis. While activation of HIF-1α decreases intestinal inflammation and is beneficial in colitis, activation of HIF-2α exacerbates colitis and increases colon carcinogenesis in animal models, primarily due to the role of epithelial HIF-2α in mounting a potent inflammatory response. Previous work from our laboratory showed that mice overexpressing intestinal epithelial HIF-2α led to massive intestinal inflammation and decreased survival. As oxygen homeostasis and HIFs are critical in embryonic development, it is not clear whether the observed intestinal inflammatory response was secondary to developmental defects. To address this question, the present study used a mouse model to temporally modulate expression of intestinal epithelial HIF-2α to assess its role in mediating inflammatory response. Remarkably, activation of HIF-2α in intestinal epithelial cells in adult mice increased expression of proinflammatory mediators; however, no decrease in survival was observed. Furthermore, in an acute model of colitis, activation of HIF-2α was sufficient to exacerbate colitis. These data confirm our previous finding that epithelial HIF-2α mediates inflammatory response and demonstrates that activation of HIF-2α is sufficient to exacerbate colitis.NEW & NOTEWORTHY Inflammatory bowel disease (IBD) is a chronic relapsing inflammatory disease of the intestinal tract. Hypoxia and activation of its downstream transcription factors hypoxia-inducible factor (HIF)-1α and HIF-2α are notable features of IBD. HIF-1α has well-characterized protective roles in IBD; however, the role of HIF-2α has been less studied. Using novel HIF-2α mouse models, we show that activation of HIF-2α in intestinal epithelial cells is sufficient to exacerbate colitis.
A model-based reassessment of the three-dimensional tuning of head direction cells in rats
Authors: Laurens Jean , Angelaki Dora E. 
Published: June 2019

In a recent study, Shinder and Taube (Shinder ME, Taube JS. J Neurophysiol 121: 4–37, 2019) concluded that head direction cells in the anterior thalamus of rats are tuned to one-dimensional (1D, yaw-only) motion, in contrast to recent findings in bats, mice, and rats. Here we reinterpret the author’s experimental results using model comparison and demonstrate that, contrary to their conclusions, experimental data actually supports the dual-axis rule (lson JJ, Jeffery KJ. J Neurophysiol 119: 192–208, 2018) and tilted azimuth model (Laurens J, Angelaki DE. Neuron 97: 275–289, 2018), where head direction cells use gravity to integrate 3D rotation signals about all cardinal axes of the head. We further show that the Shinder and Taube study is inconclusive regarding the presence of vertical orientation tuning; i.e., whether head direction cells encode 3D orientation in the horizontal and vertical planes conjunctively. Using model simulations, we demonstrate that, even if 3D tuning existed, the experimental protocol and data analyses used by Shinder and Taube would not have revealed it. We conclude that the actual experimental data of Shinder and Taube are compatible with the 3D properties of head direction cells discovered by other groups, yet incorrect conclusions were reached because of incomplete and qualitative analyses. NEW & NOTEWORTHY We conducted a model-based analysis previously published data where rat head direction cells were recorded during three-dimensional motion (Shinder ME, Taube JS. J Neurophysiol 121: 4–37, 2019). We found that these data corroborate previous models (“dual-axis rule,” Page HJI, Wilson JJ, Jeffery KJ. J Neurophysiol 119: 192–208, 2018; and “tilted azimuth model,” Laurens J, Angelaki DE. Neuron 97: 275–289, 2018) where head direction cells integrate rotations along all three head axes to encode head orientation in a gravity-anchored reference frame.
Human motor unit characteristics of the superior trapezius muscle with age-related comparisons
Authors: Kirk Eric A. , Gilmore Kevin J. , Stashuk Daniel W. , Doherty Timothy J. , Rice Charles L. 
Published: June 2019

Current understanding of human motor unit (MU) control and aging is mostly derived from hand and limb muscles that have spinal motor neuron innervations. The aim here was to characterize and test whether a muscle with a shared innervation supply from brainstem and spinal MU populations would demonstrate similar age-related adaptations as those reported for other muscles. In humans, the superior trapezius (ST) muscle acts to elevate and stabilize the scapula and has primary efferent supply from the spinal accessory nerve (cranial nerve XI) located in the brainstem. We compared electrophysiological properties obtained from intramuscular and surface recordings between 10 young (22–33 yr) and 10 old (77–88 yr) men at a range of voluntary isometric contraction intensities (from 15 to 100% of maximal efforts). The old group was 41% weaker with 43% lower MU discharge frequencies compared with the young (47.2 ± 9.6 Hz young and 26.7 ± 5.8 Hz old, P < 0.05) during maximal efforts. There was no difference in MU number estimation between age groups (228 ± 105 young and 209 ± 89 old, P = 0.33). Furthermore, there were no differences in needle detected near fiber (NF) stability parameters of jitter or jiggle. The old group had lower amplitude and smaller area of the stimulated compound muscle action potential and smaller NF MU potential area with higher NF counts. Thus, despite age-related ST weakness and lower MU discharge rates, there was minimal evidence of MU loss or compensatory reinnervation. NEW & NOTEWORTHY The human superior trapezius (ST) has shared spinal and brainstem motor neuron innervation providing a unique model to explore the impact of aging on motor unit (MU) properties. Although the ST showed higher MU discharge rates compared with most spinally innervated muscles, voluntary strength and mean MU rates were lower in old compared with young at all contraction intensities. There was no age-related difference in MU number estimates with minimal electrophysiological evidence of collateral reinnervation.