bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparison of the Visual Acuity and Refractive Error Using OPDIII and Subjective Findings in Visually Normal Subjects
Authors: Alamdar Mohaddeseh , Jafarzadehpur Ebrahim , Mirzajani Ali , Yekta Abbas Ali , Khabazkhoob Mehdi 
Published: October 2018

Purpose:
To compare the visual acuity and refractive error using OPDIII and subjective findings in visually normal subjects.

Method:
This study was performed on 75 participants (134 eyes) with an age range of 18 to 35 years. Visual acuity was evaluated using both subjective Snellen chart and OPDIII devices. Also, OPDIII objective refraction was compared with subjective refraction. Paired t test was used to compare mean visual acuity and refractive error. The 95% limits of agreement (LOAs) were reported to evaluate the agreement between subjective and objective methods.

Results:
The mean Snellen visual acuity was 0.705±0.243 logMAR in group with myopia and 0.375±0.207 logMAR in group with hyperopia. Visual acuity obtained using OPDIII was 0.632±0.270 and 0.054±0.084 logMAR in groups with myopia and hyperopia, respectively. There was a significant difference in the mean visual acuity between OPDIII and Snellen chart. The correlation of the Snellen chart with OPDIII was 0.862 and −0.172 in myopic and hyperopic groups, respectively. The 95% LOAs of the OPDIII with Snellen chart were −0.33 to 0.18 and −0.14 to 0.79 logMAR in myopic and hyperopic patients, respectively. The mean spherical power obtained by OPDIII was more negative than that of subjective refraction (OPDIII mean difference −0.272±0.335 and 0.163±0.302 DS in myopic and hyperopic groups respectively), while the cylinder power was less than that of the subjective refraction (OPDIII mean difference 0.488±0.566 and 0.030±0.255 DC in groups with myopia and hyperopia, respectively). The correlation of OPDIII with subjective refraction was 0.905, 0.920 in measurement of the spherical power and 0.908, 0.928 in measurement of the cylinder power in groups with myopia and hyperopia, respectively.

Conclusion:
Visual acuity scores were significantly better using OPDIII compared with Snellen chart in group with myopia, whereas the Snellen chart provided the better visual acuity scores in hyperopic patients. Although the correlation of OPDIII with subjective refraction in measuring the refractive error was high, OPDIII showed a significant difference with subjective refraction.
Pathological Features and Clinical Course in Patients With Recurrent or Malignant Orbital Solitary Fibrous Tumor/Hemangiopericytoma
Authors: Sagiv Oded , Bell Diana , Guo Yunxia , Su Shirley , Wester Sara T. , Jiang Kailun , Yin Vivian T. , Shinder Roman , Hayek Brent , Kim Hee Joon , Tetzlaff Michael T. , Esmaeli Bita 
Published: October 2018

Purpose:
A risk assessment score for metastasis based on age, tumor size, and mitotic figures has been suggested for nonorbital solitary fibrous tumor (SFT)/hemangiopericytoma. The authors herein examine the clinicopathological features of recurrent and metastatic orbital SFT and evaluate the existing risk assessment score for orbital SFT.

Methods:
The American Society of Ophthalmic Plastic and Reconstructive Surgery Oncology Database was queried for patients with recurrent or malignant orbital hemangiopericytoma/SFT. The medical records were reviewed for clinical and pathologic findings, treatments, and outcomes.

Results:
Eight patients from 3 institutions were identified with recurrent orbital hemangiopericytoma/SFT. Median age at diagnosis was 59 years, and 4 patients were women. The mean size of tumor was 2.1 ± 1.1 cm. All patients were initially treated with surgery and experienced local recurrence after a median of 4 (range 0.5–10) years. Five patients were treated with orbital radiation. Two patients also developed distant metastases and eventually died of their disease. Median Ki-67 was 5% (range 1–65%) and 5 mitotic figures/10 high-power fields (range 2–30). The previously described risk stratification model for nonorbital SFT did not correlate with the propensity to develop metastases in this cohort; however, both patients with distant metastasis had > 4 mitotic figures /10 high-power fields.

Conclusions:
In this cohort of recurrent orbital hemangiopericytoma/SFT, median time to recurrence was 4 years underscoring the importance of careful continued follow-up. The current risk stratification models have limited use for orbital lesions, mostly due to the fact that orbital SFTs are smaller than even the smallest size criteria in this risk assessment model.
Whole-brain structural magnetic resonance imaging–based classification of primary dysmenorrhea in pain-free phase: a machine learning study
Authors: Chen Tao , Mu Junya , Xue Qianwen , Yang Ling , Dun Wanghuan , Zhang Ming , Liu Jixin 
Published: October 2018

Abstract
To develop a machine learning model to investigate the discriminative power of whole-brain gray-matter (GM) images derived from primary dysmenorrhea (PDM) women and healthy controls (HCs) during the pain-free phase and further evaluate the predictive ability of contributing features in predicting the variance in menstrual pain intensity. Sixty patients with PDM and 54 matched female HCs were recruited from the local university. All participants underwent the head and pelvic magnetic resonance imaging scans to calculate GM volume and myometrium-apparent diffusion coefficient (ADC) during their periovulatory phase. Questionnaire assessment was also conducted. A support vector machine algorithm was used to develop the classification model. The significance of model performance was determined by the permutation test. Multiple regression analysis was implemented to explore the relationship between discriminative features and intensity of menstrual pain. Demographics and myometrium ADC-based classifications failed to pass the permutation tests. Brain-based classification results demonstrated that 75.44% of subjects were correctly classified, with 83.33% identification of the patients with PDM (P < 0.001). In the regression analysis, demographical indicators and myometrium ADC accounted for a total of 29.37% of the variance in pain intensity. After regressing out these factors, GM features explained 60.33% of the remaining variance. Our results suggested that GM volume can be used to discriminate patients with PDM and HCs during the pain-free phase, and neuroimaging features can further predict the variance in the intensity of menstrual pain, which may provide a potential imaging marker for the assessment of menstrual pain intervention.
Dysfunctional Eating Patterns of Adults With Attention Deficit Hyperactivity Disorder
Authors: Hershko Shirley , Aronis Anna , Maeir Adina , Pollak Yehuda 
Published: October 2018

Abstract
This study aimed to examine whether adult attention deficit hyperactivity disorder (ADHD) in students is associated with overeating or with unhealthy food choices. Sixty university students with and without ADHD, aged 20 to 30 years, completed the Food Frequency Questionnaire and reported their height and weight. Students with ADHD had a higher body mass index compared with students without ADHD. Although participants in both groups consumed similar amounts of servings, calories, and nutrients, students with ADHD reported lower healthy/unhealthy food consumption ratio. These findings suggest that ADHD in students is not associated with general overeating, but with a biased proportion of unhealthy versus healthy food consumption.
Evaluating Associations Between Perfectionism, Emotion Regulation, and Eating Disorder Symptoms in a Mixed-Gender Sample
Authors: Donahue Joseph M. , Reilly Erin E. , Anderson Lisa M. , Scharmer Christina , Anderson Drew A. 
Published: October 2018

AbstractPrior research supports maladaptive perfectionism as a risk factor for eating disorders; however, not all individuals with elevated levels of perfectionism endorse eating pathology, suggesting additional variables may interact with perfectionism to account for this association. The current study examined the influence of difficulties in emotion regulation on the relation between perfectionism and eating disorders. Undergraduate students (N= 309, 50.7% male) from a large university completed measures of perfectionism, emotion dysregulation, and eating pathology. The results indicated that high levels of perfectionism only accounted for significant variance in eating disorder symptoms among individuals with limited access to adaptive strategies to regulate emotions, but not among those with greater access to adaptive strategies. Findings demonstrate that clinicians and researchers should consider the role of emotion regulation among individuals with elevated levels of perfectionism and eating pathology. Future research should prospectively evaluate these associations and examine mechanisms that may further elucidate these relations.
Assessment of Dural Ectasia Using Computed Tomodensitometry as a Criterion in Marfan Syndrome
Authors: Chuzel Quentin , Dupuis-Girod Sophie , Rousset Matthieu , Decharry Charlotte , Decullier Evelyne , Pialat Jean-Baptiste 
Published: October 2018

Objective
The aim of this study was to reevaluate dural ectasia criteria in Marfan syndrome patients fulfilling the revised Ghent criteria.

Methods
Lumbar computed tomography scans of 19 Marfan patients and 30 matched control subjects were retrospectively assessed. Dural sac ratio (DSR), nerve root sleeve diameter, pedicle width, and a scalloping or meningocele presence were each assessed by 2 readers blinded from the diagnosis. Mann-Whitney-Wilcoxon tests compared the patient and control groups. Receiver operating characteristic curve analysis and multivariate models determined the optimal cutoff value.

Results
A DSR value greater than 0.69 at L5 (DSR-L5) such as L4 scalloping of more than 2.65 mm (scall-L4) and 6 or more vertebrae showing a scalloping of more than 3 mm (6-scall) were found very specific but with limited sensitivity. Multivariate model combining DSR-L5 + scall-L4 showed good positive predictive value, whereas model combining DSR-L5 + 6-scall showed good negative predictive value.

Conclusions
Assessment of DSR and vertebral scalloping allows valuable depiction of dural ectasia in Marfan syndrome patients.
Rib Fractures Mimicking Bone Metastases in 18F-PSMA-1007 PET/CT for Prostate Cancer
Authors: Panagiotidis Emmanouil , Paschali Anna , Giannoula Evanthia , Chatzipavlidou Vasiliki 
Published: October 2018

Abstract
Prostate-specific membrane antigen (PSMA) is a membrane glycoprotein that is overexpressed in prostate cancer cells. It is also expressed in other normal tissues and several other malignant and benign diseases. We present a case of a 69-year-old man with history of prostate adenocarcinoma who underwent 18F-PSMA-1007 PET/CT due to suspected biochemical recurrence. PET/CT showed 18F-PSMA-1007 uptake in healing rib fractures with no other pathologic findings. Clinicians reporting 18F-PSMA-1007 PET/CT should be aware of this potential pitfall, especially in nontypical trauma pattern (eg, solitary osseous lesion) mimicking bone metastases.
Increased Muscular MDP Activity in the Lower Extremities Caused by Multiple Arterial Thromboses
Authors: Shao Fuqiang , Li Na , Xie Peng , Li Yiman , Zhang Heng 
Published: October 2018

Abstract
Many reasons could lead to abnormal increased extraosseous tracer uptake on 99mTc-MDP bone scintigraphy. A 75-year-old man was referred a bone scintigraphy to evaluate his chest pain. The images revealed rib fractures. In addition, increased MDP activity in the muscle of the lower extremities was noted. The abnormal increased uptake in the muscles was likely related to the arterial thromboses revealed by vascular ultrasonography. The patient received interventional embolectomy.
Strategies for Complex Scalp Reconstruction in Patients With Poor Recipient Vessels
Authors: Fodor Lucian , Fodor Marius , Sobec Raluca , Sita Laura , Florian Ioan Stefan 
Published: October 2018

Abstract
Complex scalp defects with poor recipient vessels represent a challenge for plastic surgeons. In these cases, free flaps are the last resort for solving the problem. The authors present 5 difficult cases with complex large scalp and calvarium defects with unsuitable small recipient vessels for anastomoses. For these cases, the lesser saphenous vein was harvested and used as an interposition graft between the external carotid artery, the jugular vein, and the flap. Latissimus Dorsi, Anterolateral Thigh, and serratus anterior were the flaps used for reconstruction. Cranioplasty was simultaneously performed in 4 cases. The scalp defects varied from 83 to 288 cm2. All flaps survived. In 1 case (extended Latissimus Dorsi) there was local infection and wound dehiscence with marginal flap necrosis that required flap readvancement. In conclusion, end-to-end anastomosis to the external carotid artery offers strong outflow through the vein graft and flap. A large vein graft allows good outflow and is more resistant to the pressure of the skin envelope. Anastomosis to large neck vessels (internal or external jugular) facilitates drainage since there is also an aspiration effect due to the venous flow circulation through it.
Management of Conditions Associated With Aging and Older Adults Using Therapeutic Electromagnetic Energy
Authors: Bridges Michael , Hilliard Jeremy , Chui Kevin 
Published: October 2018

Objective:
To assess the effectiveness of therapeutic electromagnetic energy in the management of conditions associated with an aging and older adult population.

Methods:
A systematic review of literature from 2008 to 2018 was completed in PubMed, CINAHL, and Science Direct. We also reviewed sources to identify additional relevant studies. Studies in this review were limited to randomized controlled trials that evaluated the effects of shortwave diathermy or pulsed electromagnetic energy units in treating conditions commonly experienced by adults older than 50 years. Study quality was determined using the Physiotherapy Evidence Database (PEDro) classification scale.

Results:
Fifteen randomized controlled trials met our search criteria. Multiple pathologies were evaluated with the studies examining treatment effects of knee osteoarthritis (n = 12), frozen shoulder (n = 1), postoperative rotator cuff repair (n = 1), and postmenopausal osteoporosis (n = 1). Of the 12 studies that examined knee osteoarthritis, 2 compared pulsed electromagnetic field to placebo or sham, 2 compared the addition of shortwave diathermy to strengthening activities alone, 3 evaluated shortwave diathermy dosage, 3 compared shortwave diathermy to other modalities, and 2 reviewed the benefits of adding pulsed electromagnetic field to other modalities and exercise. Due to the high degree of variability in protocols and outcome measures among studies, meta-analysis was not appropriate. Studies on knee osteoarthritis reported that the use of pulsed electromagnetic field and shortwave diathermy provides statistically significant improvement in pain and function compared with placebo, sham, or control, although there appears to be no benefit in using either form of electromagnetic radiation in addition to or in place of another modality. It also appears that dosage does not significantly change short-term outcomes. These findings are similar to those identified in other recently published systematic reviews that focused exclusively on knee osteoarthritis. Subjects with shoulder pathologies showed improvements in pain, mobility (range of motion), function, activities of daily living, and pain medication usage with pulsed electromagnetic field or shortwave diathermy. Changes in postmenopausal bone density were similar when pulsed electromagnetic field was compared with medication.

Conclusion:
Shortwave diathermy and pulsed electromagnetic frequency demonstrate similar clinical benefits as other modalities for improving pain, function, and quality of life in the short-term. Further research is needed to better evaluate the parameters of electromagnetic energy and effects for other conditions commonly affecting aging and older adults and at other treatment sites on the body.
Mechanisms of Injury in APOL1-associated Kidney Disease
Authors: Ma Lijun , Divers Jasmin , Freedman Barry I. 
Published: October 2018

Background.
An improved understanding of the pathogenesis in apolipoprotein L1 (APOL1) gene–associated chronic kidney disease (CKD) arose from observations in kidney transplantation. APOL1 genotyping could soon improve the safety of living kidney donation in individuals with recent African ancestry and alter the allocation of deceased donor kidneys.

Methods.
This article reviews the potential mechanisms that underlie development of APOL1-associated nephropathy. Roles for circulating APOL1 protein versus intrinsic renal expression of APOL1 are discussed, as well as the requirement for modifying genetic and/or environmental factors.

Results.
Abundant evidence supports local kidney production of APOL1 renal-risk variant protein in the development of nephropathy; this is true in both native kidney disease and after renal transplantation. Only a minority of kidneys from individuals with APOL1 high-risk genotypes will develop CKD or manifest shorter renal allograft survival after transplantation. Therefore, modifying factors that explain why only a subset of kidneys develops nephropathy remain critical to identify. It appears likely that environmental exposures, as opposed to major APOL1-second gene interactions, will prove to be stronger modifiers of the risk for nephropathy.

Conclusions.
The evolving understanding of the pathogenesis in APOL1-associated nephropathy will identify biomarkers predicting nephropathy in individuals at high genetic risk and lead to novel therapies to prevent or slow native CKD progression and prolong survival of transplanted kidneys. In the interim, the National Institutes of Health–sponsored “APOL1 Long-term Kidney Transplantation Outcomes” Network will determine whether APOL1 genotyping in individuals with recent African ancestry improves outcomes and safety in kidney transplantation.
Mild, moderate and severe: terminology implications for clinical and experimental traumatic brain injury
Authors: Yamamoto Satoshi , Levin Harvey S. , Prough Donald S. 
Published: October 2018

Purpose of review
When describing clinical or experimental traumatic brain injury (TBI), the adjectives ‘mild,’ ‘moderate’ and ‘severe’ are misleading. ‘Mild’ clinical TBI frequently results in long-term disability. ‘Severe’ rodent TBI actually resembles mild or complicated mild clinical TBI.

Recent findings
Many mild TBI patients appear to have recovered completely but have postconcussive symptoms, deficits in cognitive and executive function and reduced cerebral blood flow. After moderate TBI, 31.8% of patients died or were discharged to skilled nursing or hospice. Among survivors of moderate and severe TBI, 44% were unable to return to work. On MRI, 88% of mild TBI patients have evidence of white matter damage, based on measurements of fractional anisotropy and mean diffusivity/apparent diffusion coefficient. After sports concussion, clinically recovered patients have abnormalities in functional connectivity on functional MRI. Methylphenidate improved fatigue and cognitive impairment and, combined with cognitive rehabilitation, improved memory and executive functioning. In comparison to clinical TB, because the entire spectrum of experimental rodent TBI, although defined as moderate or severe, more closely resembles mild or complicated mild clinical TBI.

Summary
Many patients after mild or moderate TBI suffer long-term sequelae and should be considered a major target for translational research. Treatments that improve outcome in rodent TBI, even when the experimental injuries are defined as severe, might be most applicable to mild or moderate TBI.
Oliver Heaviside: an accidental time traveller
Authors: Nahin Paul J. 
Published: October 2018

A little discussed aspect of Heaviside's work in electromagnetics concerned faster-than-light (FTL) charged particles, precursors to the hypothetical tachyon and his discovery that such motion should produce a characteristic radiation signature (now calledCherenkov radiation). When Heaviside wrote, the time travel implications of FTL were not known (Einstein was still a teenager), and in this paper some speculations are offered on what Heaviside would have thought of FTL time travel, and of the associated (now classic) time travel paradoxes, including the possibility (or not) of sending information into the past.This article is part of the theme issue ‘Celebrating 125 years of Oliver Heaviside's ‘Electromagnetic Theory’’.
The Noether current in Maxwell's equations and radiation under symmetry breaking
Authors: Sinha Dhiraj , Amaratunga Gehan 
Published: October 2018

Symmetries in physical systems are defined in terms of conserved Noether Currents of the associated Lagrangian. In electrodynamic systems, global symmetry is defined through conservation of charges, which is reflected in gauge symmetry; however, loss of charges from a radiating system can be interpreted as localized loss of the Noether current which implies that electrodynamic symmetry has been locally broken. Thus, we propose that global symmetries and localized symmetry breaking are interwoven into the framework of Maxwell's equations which appear as globally conserved and locally non-conserved charges in an electrodynamic system and define the geometric topology of the electromagnetic field. We apply the ideas in the context of explaining radiation from dielectric materials with low physical dimensions. We also briefly look at the nature of reversibility in electromagnetic wave generation which was initially proposed by Planck, but opposed by Einstein and in recent years by Zoh.This article is part of the theme issue ‘Celebrating 125 years of Oliver Heaviside's ‘Electromagnetic Theory’’.
Species limits in butterflies (Lepidoptera: Nymphalidae): Reconciling classical taxonomy with the multispecies coalescent
Authors: Matos-Maraví Pável , Wahlberg Niklas , Antonelli Alexandre , Penz Carla M. 
Published: October 2018

AbstractSpecies delimitation is at the core of biological sciences. During the last decade, molecular-based approaches have advanced the field by providing additional sources of evidence to classical, morphology-based taxonomy. However, taxonomy has not yet fully embraced molecular species delimitation beyond threshold-based, single-gene approaches, and taxonomic knowledge is not commonly integrated to multi-locus species delimitation models. Here we aim to bridge empirical data (taxonomic and genetic) with recently developed coalescent-based species delimitation approaches. We use the multispecies coalescent model as implemented in two Bayesian methods (DISSECT/STACEY and BP&P) to infer species hypotheses. In both cases, we account for phylogenetic uncertainty (by not using any guide tree) and taxonomic uncertainty (by measuring the impact of using or not a priori taxonomic assignment to specimens). We focus on an entire Neotropical tribe of butterflies, the Haeterini (Nymphalidae: Satyrinae). We contrast divergent taxonomic opinion—splitting, lumping and misclassifying species—in the light of different phenotypic classifications proposed to date. Our results provide a solid background for the recognition of 22 species. The synergistic approach presented here overcomes limitations in both traditional taxonomy (e.g. by recognizing cryptic species) and molecular-based methods (e.g. by recognizing structured populations, and not raise them to species). Our framework provides a step forward towards standardization and increasing reproducibility of species delimitations.