bluuebunny/crossref_metadata_2025_split huggingface dataset:
Laparoskopik kolesistektomi cerrahisi geçiren hastalarda neostigmin ve sugammadeks uygulamasının postoperatif bulantı kusma üzerine etkilerinin karşılaştırılması
Authors: Özbilen Fisun , Karacaer Feride , HATİPOĞLU Zehra , ÖZALEVLİ Mehmet , GÜNEŞ Yasemin 
Published: April 2018

Amaç: Bu çalışmada laparoskopik kolesistektomi yapılan hastalarda sugammadeks ve neostigmin uygulamasının postoperatif bulantı kusma üzerine etkilerinin karşılaştırılması amaçlandı. Gereç ve Yöntem: Bu çalışmaya, ASA I-III statüsünde olan, öngörülen cerrahi süresi 150 dakikayı aşmayan, APFEL Skoruna göre %40 ın üzerinde olan 60 hasta dahil edildi. Basit rasgele yöntemle randomize edilen hastalar neostigmin grubu (Grup I) ve sugammadeks grubu olmak üzere iki gruba ayrıldı. Anestezi indüksiyonunda tüm hastalara tiyopental 5-7 mg kg-1, rokuronyum 0,5 mg kg-1 intravenöz olarak uygulanarak endotrakeal entübasyon gerçekleştirildi. Oksijen (%33) + azot protoksit (%67) +desfluran ile anestezi idamesi sağlandı. Anestezi uygulamasının sonlandırılmasında son cilt dikişi atılırken iki grupta da desfluran ve N2O kesilerek %100 oksijene geçildi. Eş zamanlı olarak kas gevşeticiyi antagonize etmek için grup I’e neostigmin, grup II’ye sugammadeks uygulandı. Ekstübasyon ve derlenme süresi, bulantı ve kusma ile diğer olası yan etkiler değerlendirildi.Bulgular: Postoperatif esktübasyon ve derlenme süresi sugammadeks grubunda nesotigmin grubundan daha kısa idi. Postoperatif bulantı ve kusma ilk 30 dakikada sugammadeks grubunda nesotigmin grubundan daha az olmasına rağmen istatistiksel olarak anlamlı değildi. Sonuç: Bulantı ve kusma riski yüksek olgularda desfluran ile oluşturulan genel anestezide dekürarizasyon amacıyla neostigmin ya da sugammadeks uygulamasının bulantı kusma açısından birbirlerine üstünlükleri olmadığı kanısına varıldı.
Influence of total knee arthroplasty approaches on component positioning
Authors: Kaya Biçer Elcil , Sözbilen Murat Celal , Aydoğdu Semih , SUR Hakkı 
Published: April 2018

Purpose: The aim of this study was to evaluate the influence of subvastus and medial parapatellar total knee arthroplasty approaches on component positioning and to explore the possible negative effects of potentially more restrictive approaches especially in highly deformed knees.Materials and Methods: 88 knees of 84 patients (46 knees operated with medial parapatellar approach (group 1), and 46 knees operated with subvastus approach (group 2)) who had undergone total knee arthroplasty. The patients were also regrouped according to their preoperative mechanical axis deviations. Postoperative femoral and tibial component positioning on frontal and sagittal planes were evaluated.Results: Frontal femoral (α) and tibial (β) component angles as well as sagittal femoral and tibial component angles were not significantly different between two groups (mean values of α of groups 1&amp;2: 96.79±2.86° and 96.81±3.22°, respectively, of β 89.07°± 3.45° and 89.97°± 3.00° respectively, of sagittal femoral angle 4.85° ± 3.84° and 3.31° ± 3.58°, respectively, of sagittal tibial angle 5.10° ± 3.88° and 4.08 °± 3.18°, respectively). Postoperatively, posterior tibial slope was significantly decreased in both groups. Conclusion: None of the total knee arthroplasty approaches tested in this study found to exert a significant effect on component positioning even in highly deformed knees. The components can be placed properly utilizing both approaches.
İntrakranial kanamaların prognozunda biyokimyasal belirteçler
Authors: Yüksel Ulaş , Öğden Mustafa , Akkurt İbrahim , Bakar Bülent , Kısa Üçler , Özveren Mehmet Faik 
Published: April 2018

Amaç: Bu çalışmada, intrakranial kanaması olan hastaların rutin laboratuvar bulgularını inceleyerek prognozu belirlemeye yönelik bir algoritma oluşturulması amaçlandı.Gereç ve Yöntem: İntrakranial kanama ile takip edilen ve cerrahi tedavi uygulanan hastalar spontan subaraknoid kanama, spontan intraserebral hematom ve subdural hematom grupları olarak üç gruba ayrıldı. Daha sonra cerrahi öncesi ve sonrası ölçülen serum sodyum, potasyum, C-reaktif protein değerleri ve kan lökosit ve nötrofil düzeyi sonuçları karşılaştırıldı. Bulgular: Yirmi sekiz hasta (10 kadın, 18 erkek) çalışma kapsamına alındı. Tüm parametreler açısından gruplar arasında fark görülmedi Ancak intraserebral hematom grubunda postoperatif lökosit sayılarının preoperatif değerden yüksek olduğu; subraknoid kanama grubunda postoperatif sodyum düzeyinin preoperatif değerden yüksek olduğu saptandı. Buna ek olarak, subaraknoid kanama grubunda Glasgow Çıkış Ölçeği puanları ile preoperatif, preoperatif ve postoperatif sodyum değerleri arasında negatif korelasyon bulundu. Subdural hematom grubunda Glasgow Çıkış Ölçeği ve preoperatif C-reaktif protein değerleri arasında negatif korelasyon olduğu tespit edildi.Sonuç: Sonuç olarak subaraknoid kanamalarda ameliyat öncesi ve sonrası ölçülen serum sodyum değerlerinin; spontan intraserebral hematomlarda ise yaş, Glasgow Koma Ölçeği, ameliyat öncesi ve sonrası ölçülen CRP değerlerinin ve subdural hematomlarda ameliyat öncesi ölçülen CRP değerlerinin ve prognozu belirlemede birer belirteç olabileceği düşünüldü.
Sonographic identification of isolated incompetent perforating veins and their correlation with age, sex, body mass index and CEAP classification
Authors: AKTÜRK Yeliz , KURT Aydın , İDİLMAN İlkay Sedakat 
Published: April 2018

Purpose: Isolated incompetent perforating veins (IPVs) are poorly discussed in the literature and their importance and prevalence is unknown. This study aims to assess the prevalence and their relation with several factors; age, sex, location and body mass index (BMI). Materials and Methods: A total of 803 limbs of 485 patients were evaluated with duplex ultrasonography. The clinical severity of the affected limbs were assessed according to CEAP classification. Incompetent perforating veins were considered isolated if neither superficial nor deep venous system reflux were associated. Results: 617 legs were classified as CEAP 0-2, 186 legs were classified as CEAP 3 or higher. There was a significant correlation with age, sex, BMI, incompetent perforating veins and CEAP stage. 22 of 803 legs (2.7%) have been shown to have isolated incompetent perforating veins. Total of 25 isolated incompetent perforating veins were detected in these 22 legs (19 patients; 14 females, 5 males). All patients with isolated incompetent perforating veins had CEAP stage 0-2. The mean BMI of these patients was lower than the whole patients groups. Conclusion: The results of this study show that isolated IPVs may also be a cause of venous insufficiency. It may be inferred that the increase in the patients' weights or BMIs does not lead to development of isolated incompetent perforating veins because the BMI of the patients with isolated incompetent perforating veins are found to be lower.
Investigation of monoamine oxidase inhibitory activities of new chalcone derivatives
Authors: CAN Nafiz Öncü 
Published: April 2018

Purpose: In the present study, it is aimed to investigate monoamine oxidase (MAO) enzyme inhibition potencies of some new chalcone derivatives. Materials and Methods: Nine novel chalcone derivatives were synthesized and structures of the synthesized compounds (2a-2i) were confirmed by spectroscopic methods. Inhibitory activities of the compounds against MAO-A and MAO-B enzymes have been determined via in-vitro fluorometric method. Effects of the compounds on substrate level were measured by an LC-MS/MS method. Enzyme kinetics studies were carried out for the most active compound 2i using Lineweaver–Burk plots.Results: Compounds 2c, 2e and 2i displayed notable inhibition against hMAO-B with lower IC50 values than 1 µM. The most active compound 2i displayed significant inhibition by IC50 of 0.13 µM. Results of substrate level quantification study were in an agreement with fluorometric enzyme inhibition assay. Competitive type of inhibition was determined for compound 2i as a result of enzyme kinetic studies. Conclusion: Synthesized compounds displayed more selectivity towards hMAO-B. In this study, the results of inhibitor effects of compounds 2c, 2f and 2i are promising for the synthesis of similar derivatives with enhanced MAO inhibitory activity and therefore for the development of new molecules which may be drug candidates against Parkinson's disease.
Meme, prostat, kolorektal ve akciğer kanserlerinde çevresel risk faktörleri ve risk düzeylerinin belirlenmesi: olgu-kontrol çalışması
Authors: Açıkgöz Ayla , Çımrın Dilek , Ergör Gül 
Published: April 2018

Amaç: Bu çalışmanın amacı meme, prostat, kolorektal ve akciğer kanserini etkileyen çevresel risk faktörlerini belirlemek ve risk düzeyi belirleme programları kullanılarak tanı konmadan önceki risk düzeylerini değerlendirmektir. Gereç ve Yöntem: Bu çalışma İzmir’in Balçova ilçesinde yapılan olgu-kontrol araştırmasıdır. 2008-2013 yılları arasında akciğer, meme, kolorektal ve prostat kanseri tanısı alanlar araştırmanın olgu grubunu oluşturmuştur. Katılımcıların sosyodemografik özellikleri, yaşam tarzı ve beslenme alışkanlıkları anketle belirlenmiştir. Olgu ve kontrol gruplarının kanser risk düzeyleri hesaplanmıştır. Olgu grubunda 57 meme, 52 prostat, 22 kolorektal ve 42 akciğer kanseri olgusu bulunmaktadır. Meme kanseri olguları 216 kadın, prostat kanseri olguları 211 erkek, kolorektal ve akciğer kanseri olguları ise 427 kadın ve erkek kontrol ile karşılaştırılmıştır. Bulgular: Altmış yaşın altında olanlarda meme kanseri 2.36 kat fazladır. Fazla kilolu ya da şişman gruplarında meme kanseri daha az görülmüştür. Akciğer kanseri erkeklerde 2.04 kat, sigara içenlerde 4.10 kat, sigarayı bırakanlarda 2.19 kat fazladır. Sonuç: Yaş ve beden kütle indeksiyle meme kanseri; inflamatuar bağırsak hastalığıyla kolorektal kanserler; erkek cinsiyeti ve sigara içmeyle akciğer kanseri arasında ilişki bulunmuştur. Olgu ve kontrol grupları arasında hesaplanan kanser risk düzeyleri bakımından anlamlı fark saptanamaması olgu sayılarının az olmasından ya da kullanılan risk hesaplama programlarının Türk toplumuna uygun olmamasından kaynaklanabilir.
Stres üriner inkontinans tedavisinde transobturator tape ile gerilimsiz vajinal tapenin karşılaştırılması
Authors: Sukgen Gökmen , Altunkol Adem , Köse Gültekin , Tüfekçi Ertuğrul Can 
Published: April 2018

Amaç: Stres üriner inkontinans tedavisinde gerilimsiz vajinal tape ve transobturator tape uygulamasının etkinliği, güvenliği ve her iki yöntemin hayat kalitesini karşılaştırmayı amaçladık.Gereç ve Yöntem: Nisan 2006 ile Nisan 2008 tarihleri arasında stres üriner inkontinans nedeniyle transobturator tape uygulanan 45 hasta ile gerilimsiz vaginal tape uygulanmış 33 hastanın verileri karşılaştırıldı. Demografik özellikleri, başarı oranı, kısa dönemdeki komplikasyonlar ve operasyonun semptomlar ve yaşam kalitesi üzerine etkileri değerlendirildi.Bulgular: Total 78 hastanın ortalama yaşı 48.77±4.78 (34-79) olarak hesaplandı. Transobturator tape yapılan hastaların ortalama operasyon süresi sırasıyla 12.89±4.09 dakika idi. Gerilimsiz vaginal tape yapılan hastaların ortalama operasyon süresi 30.21±2.89 dakika idi. Ortalama operasyon süresi gerilimsiz vaginal tape yapılan gurpta istatistiksel olarak daha yüksekti. Urogenital distress inventory-6 anketinin analizinde her iki grubun kendi içinde postoperatif dönemde anlamlı derecede düzelme olduğu tespit edildi.Sonuç: Her iki prosedür güvenli ve etkili metodlardır. Aynı zamanda hayat kaliteleri üzerine istatistiksel olarak anlamlı derecede düzelmeler yaptığını tespit ettik. Yine de stres üriner inkontinansın tedavi modalitelerinin etkinliğini değerlendirmek için randomize kontrollü ve daha uzun takip süreleri olan çalışmalara ihtiyaç vardır.
Bipolar ötimik hastalarda uykunun genel özellikleri ve uyku bozuklukları
Authors: KESKİN Necla , TAMAM Lut 
Published: April 2018

Amaç: Bu çalışmada ötimik dönemde olup, sorulunca uyku sorunu bildiren hastalarda uykunun genel özellikleri ile görülen uyku bozukluklarının belirlenmesi amaçlanmıştır. Gereç ve Yöntem: Çalışmaya Çukurova Üniversitesi Tıp Fakültesi Ruh Sağlığı ve Hastalıkları Anabilim Dalı Bipolar Bozukluk Birimi’ne ayaktan başvuran ve “Genel olarak uyku düzeninizden memnun musunuz? Son 1 yıldır uyku düzeninizden memnun muydunuz?” sorularından en az birine “hayır” ve / veya “Başkalarının gözlemine göre uykunuzda sorun var mı?” sorusuna “evet” yanıtı veren 18-65 yaş arası 57 hasta alındı.Sosyodemografik Veri Formu ve Bipolar Bozukluk Veri Formu dolduruldu. Genel Uyku Anketi (GUA) ile uykunun genel özellikleri ve uyku bozuklukları sorgulandı. Tüm hastalar Epworth Uykululuk Ölçeği (EUÖ)’ni doldurdu. Bulgular: Uykuyu başlatma, sürdürme ve sonlandırma evrelerinde sıklıkla sorun yaşadığı gözlenen hastaların %43.9’unun 10 saatten fazla uyuduğunu, %54.4’ünün horladığını, % 1.8’inin uyku apnesi yaşadığını bildirdiği gözlenmiştir. Hastaların %36.8’inin uyku sorunlarının mevsimsel özellik gösterdiği saptanmış, uyku sorunları çoğunlukla ikincil ve ruhsal kökenli olarak tanımlanmıştır. Sonuç: BPB’un ötimik dönemlerinde uyku bozuklukları oldukça sık görülen, tedavi için başvuru nedeni olmayan, gözden kaçan ve hastalık seyri, işlevsellik ve yaşam kalitesi üzerine etkileri iyi bilinen bozukluklar olup, BPB tanılı her hastanın uyku alışkanlıkları, yapısı ve bozuklukları açısından ayrıntılı olarak incelenmesi büyük önem taşımaktadır.
Effect of baricity of low dose diluted bupivacaine with fentanyl on the duration and quality of spinal block in transurethral prostatectomy
Authors: POLAT Reyhan , BUMİN AYDIN Gözde , AKTAY İNAL Meltem , Ergil Jülide , Topçu Gülöksüz Çiğdem , Baran İlkay 
Published: April 2018

Purpose: In this prospective randomized controlled trial, we investigated whether density of low dose diluted bupivacaine with fentanyl effects the duration and quality of the spinal block for transurethral prostatectomy (TURP) in elderly patients.Materials and Methods: Sixty patients requiring elective TURP were randomly allocated into two groups. Group H (n=30) received fentanyl 20 mcg+hyperbaric bupivacaine 0.5% (1.5 ml)+ saline 1.1 ml. Group I (n=30) received fentanyl 20 mcg+plain bupivacaine 0.5% (1.5 ml)+ saline 1.1 ml in total, bupivacaine 0.25% (3 ml) intrathecally. Onset, duration of the sensory block, the degree of motor block, perioperative anesthesia quality, side-effects, analgesic-free period were assessed.Results: The median peak level of the sensory block was significantly higher in Group H than in Group I. The time to the first analgesic request was longer in Group H). There were no differences between the groups for degree of the motor block, quality of anaesthesia, or adverse effects.Conclusion: Low-dose diluted hyperbaric bupivacaine with fentanyl provides adequate anaesthesia, postoperative analgesia without haemodynamic instability or prolonging the recovery time for TURP in elderly patients.
Obstetric outcome of teenage pregnancies in a tertiary care centre in Mangalore, Karnataka, India
Authors: Emani Anusha , Shetty K. Shraddha 
Published: April 2018

Background: Teenage pregnancy is a social problem affecting maternal and child health. In India, teenage pregnancy is an important public-health problem, although the national policy of the Government of India advocates the minimum legal age of marriage for girls to be 18 years. The aim of the present study was to observe the obstetric outcome in Teenage pregnanciesMethods: A retrospective analysis of all Teenage pregnancies was done over a period of 1 year from August 2014 to July 2015. Case sheets of all teenage mothers delivered during that period were retrieved. Maternal and neonatal outcome were analyzed and compared with pregnant women ≥20 years of age. Results: 5859 deliveries occurred during the study period, teenage deliveries were 457.The prevalence of teenage deliveries was 7.8%. Cesarean delivery rate was 56% vs 42% (p value<0.05) among teenagers compared to non teenage pregnant mothers. Preterm delivery rate was higher in teenagers 24% vs 14 % (p<0.05). 39(8.6%) teenage mothers had developed hypertension in pregnancy and 42(8.3%) among non-teenagers (p>0.05). Teenage mothers had increased Low birth weight rates 24% vs 10% (p<0.05).Conclusions: Teenage pregnancies has a negative impact on maternal and perinatal health. Hence strict laws should be enforced to prohibit teenage marriages. Adolescent girls should be educated about safe sex practices, contraception and complications of teenage pregnancies on maternal and child health.
Ormeloxifene in the management of dysfunctional uterine bleeding
Authors: Devi L. Thulasi , Nimonkar Ravi 
Published: April 2018

Background: Dysfunctional Uterine Bleeding (DUB), is the commonest cause of Abnormal Uterine Bleeding (AUB). It causes morbidity, anaemia, and unnecessary hysterectomies in women of fertile age group. This study attempts to study efficacy of medical management especially Selective Estrogen Receptor Modulator (SERM) namely Ormeloxefine (ORM) (Sevista®) in Perimenopausal women. Ormeloxifene was marketed in India for contraception under brand names Centron, Saheli, Choice-7, Novex and Novex-DS. It’s a benzopyran derivative also known as Centchroman which causes asynchronousity between ovulation and menstrual cycles possibly because of both estrogenic and anti-estrogenic actions. It has been known to cause delay in ovulation in clinical trials; however, majority have been unaffected. It causes delay in proliferation of endometrium thereby causing asynchronous cycles. It also improves motility of ciliary lining of Fallopian tubes thereby reducing the chances of implantation of fertilized egg. Methods: This study is aimed at evaluation of subjective and objective stastical benefits and side effects in treatment of DUB in perimenopausal age group with ORM and commonly used 19 nortestosterone compound (progesterone); Norethisterone (NET).Results: Primary outcome were analyzed at the end of every 3 months and at the end of one year finally. Secondary outcomes of the study in each arm were also assessed. There was stastically significant increase in Hb and stastically significant decrease in ET. Data analysis was done for variables in each arm by t-test to estimate the mean, median, range P and t value for a conclusion. Differences were taken as significant when P<0.05.Conclusions: ORM is a safe, cost effective, non-steroidal, non-hormonal drug with convenient dosage and better compliance for medical management of perimenopausal DUB with minimum focal pathology. Side effects observed need more evaluation with larger sample size to be statistically significant.
Study of menstrual disorder in adolescent girls at tertiary care centre in rural area
Authors: Yadav Anubhuti , L. Masand Deepa 
Published: April 2018

Background: Total adolescent world population is 16%. Adolescents (10-19 years) constitute 21.3% i.e. nearly 1/5th of total population of India. 19% of the total population-faces a series of serious challenges not only affecting their growth and development but also their livelihood as adults. The objective of the current study was to observe the menstrual disorders among adolescent females and to observe the demographic profile and assess hygiene practices during menstruation and grade of anemia due to menstrual morbidity. Methods: A random selection of adolescent’s females were done from gynaecology outpatient department at a tertiary care hospital in rural area. Study done on 180 adolescent girls from January 01, 2016 to June 31st, 2017, it is a descriptive type of observational study. Counseling done of adolescent females on menstrual hygiene and nutrition. Results: Most common menstrual morbidity seen in this study is dysmenorrhea (41.66%) followed by heavy menstrual bleeding i.e 25% and irregular menstrual bleeding (13.33%) subsequently. All these problems are associated with their practices used during menstruation. Poor menstrual hygiene was seen associated with 30 to 35% of abdominal cramps and mood swings, heavy menstrual bleeding and nutritional deficiency leads to moderate anemia (7 to10 gm%) in 83%.Conclusions: Due to unhygienic practices and lack of education and awareness about hygiene many of the girls were suffering from reproductive tract infections and poor nutrition leads to anemia. So, we all need to educate them about hygiene and spread awareness about the various services provided by the government like supplying of sanitary napkins to overcome infections.
Effect of pregnancy induced hypertension on pregnancy outcome: a hospital based cross sectional study at a tertiary care hospital
Authors: Bindu K. Hima , Devi E. Rama 
Published: April 2018

Background: I Pregnancy induced hypertension causes intra uterine growth retardation, pre-mature delivery, intra uterine death of fetus, abruption placentae. It also causes increased morbidity and mortality among women. The objective of the present study is to observe the effect of pregnancy induced hypertension on pregnancy outcome.Methods: A hospital based cross sectional study was carried out to study the effect of pregnancy induced hypertension on pregnancy outcome for a period of two years from April 2004 to March 2006 at Gandhi Medical College, Hyderabad. Results: The mean maternal age in group I was 22.9 years comparable to group II. The incidence of PIH was 10.7% among primipara compared to 9.1% among multi parous women. Mean gestational age at entry to the present study was comparable among both the groups. Mean gestational age at delivery was higher in normotensive women compared to women with PIH. The incidence of low birth weight was 70% among PIH group compared to only 16.7% in normotensive group and this difference was found to be statistically significant. The incidence of intra-uterine growth retardation (IUGR) was 70% among PIH group compared to only 16.7% in normotensive group and this difference was found to be statistically significant. The incidence of pre-term delivery was 70% among PIH group compared to only 16.7% in normotensive group and this difference was found to be statistically significant.Conclusions: T Pregnancy induced hypertension was positively associated with adverse outcome. Early diagnosis and proper management can help to overcome and tackle most of the adverse outcomes.
Changing trends of blood transfusion requirement in obstetrics and gynaecology
Authors: Singh Rajesh Kumar , Anne Sirisha , P. Sruthi Ravindran 
Published: April 2018

Background: With the advent of the new pharmacological drugs and surgical advances compared to yesteryears, that the requirement of blood transfusion in obstetrics and gynaecology has decreased. Earlier obstetrical haemorrhage had been the commonest reason for blood transfusion. This trend seems to be changing. To evaluate this an observational study was done at a peripheral hospital to assess various indications for blood transfusion in maternity ward over a period of one year. Methods: A total of 129 transfusions were studied in a period of one year and requirement of transfusion was assessed by the same team of doctors as per AABB guidelines for blood transfusion. Results: A total of 87 obstetric patients required transfusion out of which 51.2% patients were transfused for anaemia near term. Postpartum haemorrhage constituted only 1.15% and ante partum haemorrhage only 4.6%. 17.24% of patients were transfused for incomplete abortion after taking medical abortion. 42 patients were transfused blood for various gynaecological reasons of which puberty menorrhagia constituted 19.01% and patients with perimenopausal bleeding were 28.57%.Conclusions: This study highlights the changing trends in requirement of blood transfusion and the need to emphasise on antenatal nutrition, supplements and contraception.