bluuebunny/crossref_metadata_2025_split huggingface dataset:
Resistance Training Frequencies of 3 and 6 Times Per Week Produce Similar Muscular Adaptations in Resistance-Trained Men
Authors: Saric Juraj , Lisica Domagoj , Orlic Ivan , Grgic Jozo , Krieger James W. , Vuk Sasa , Schoenfeld Brad J. 
Published: October 2018

Abstract
Saric, J, Lisica, D, Orlic, I, Grgic, J, Krieger, JW, Vuk, S, and Schoenfeld, BJ. Resistance training frequencies of 3 and 6 times per week produce similar muscular adaptations in resistance-trained men. J Strength Cond Res 33(7S): S122–S129, 2019—We examined the effects of resistance training (RT) frequency performed 3 times per week (RT3) vs. RT performed 6 times per week (RT6) under volume-equated conditions in resistance-trained men. Twenty-seven men were randomly allocated to RT3 (n = 14) or RT6 (n = 13). The supervised training intervention lasted for 6 weeks. Upper- and lower-body strength were assessed using the 1 repetition maximum test. Also, muscular endurance (60% 1 repetition maximum performed to momentary failure) and muscle thickness (elbow flexors, elbow extensors, rectus femoris, and vastus intermedius) were measured before and after intervention. Pre-to-post intervention, both groups increased upper-body strength (RT3: +4%; RT6: +6%) and lower-body strength (RT3: +22%; RT6: +18%) with no significant between-group differences. No significant pre-to-post intervention increases in muscular endurance were seen in either of the training groups. Both groups increased elbow extensor thickness (RT3: +14%; RT6: +11%), rectus femoris thickness (RT3: +5%; RT6: +6%), and vastus intermedius thickness (RT3: +10%; RT6: +11%) with no significant between-group differences. Only the RT3 group significantly increased elbow flexor thickness from pre-to-post intervention (+7%). When training volume is equated, it seems that RT performed either 3 or 6 times per week can result in similar strength gains over a 6-week training period. Furthermore, under volume-equated conditions, comparable hypertrophy results may also be expected with both RT frequencies. Finally, no changes were seen in muscular endurance possibly because of the considerable interindividual variability in responses. The findings presented herein might be of interest to coaches, exercise practitioners, athletes, and recreational trainees.
Muscle Damage–Based Recovery Strategies Can Be Supported by Predictive Capacity of Specific Global Positioning System Accelerometry Parameters Immediately a Post-Soccer Match-Load
Authors: da Silva Cristiano D. , Machado Guilherme , Fernandes Alex Andrade , Teoldo Israel , Pimenta Eduardo M. , Marins João C. B. , Garcia Emerson S. 
Published: October 2018

Abstract
da Silva, CD, Machado, G, Fernandes, AA, Teoldo, I, Pimenta, EM, Marins, JCB, and Garcia, ES. Muscle damage–based recovery strategies can be supported by predictive capacity of specific global positioning system accelerometry parameters immediately after soccer match-load. J Strength Cond Res 35(5): 1410–1418, 2021—Soccer match-load can be linked to recovery kinetic markers. However, match variability hinders the magnitude of relationship between parameters of interest. Therefore, we examined the correlation between 21 global positioning system accelerometry (GPS-A) parameters and changes in serum creatine kinase (CK) concentrations, muscle soreness (MS), and perceptive recovery quality (PRQ) assessed at baseline (1 h before) and post (0 minute, 2, 4, and 24 hours) a standardized 90-minute match-simulation in 20 university players. Global positioning system accelerometry (15 Hz) data were tested as manufacturer and configurable thresholds. Four GPS-A parameters showed moderate to very large correlations with CK changes at all time points (average speed [avgSP, r = 0.75 to r = 0.84]; running symmetry foot strikes [RSfst, r = 0.53–0.63]; running series [RunS, r = 0.53–0.61]; and acceleration distance [AccD ≥ 1.5 m·s−2; r = 0.46–0.61]). Sprint count (≥2 m·s−2), AccD (≥2.5 m·s−2) and speed exertion (SpEx) had a moderate to large correlation (r = 0.46–0.56) with CK changes from 2 to 24 hours. Changes in MS at 0 minute had large correlation with avgSP (r = 0.53) and moderate with deceleration distance (≥−2 and ≥−3 m·s−2; r = 0.47, r = 0.48, respectively). The PRQ changes had moderate inverse correlation with avgSP at 0 minute (r = −0.39) and SpEx at 2 h (r = −0.69). Our results suggest that during a simulated soccer protocol with a standard workload, only the avgSP has practical application for predicting CK changes over 24 hours, allowing for a decision-making toward a postgame recovery based on previously known CK cutoff points. Global positioning system accelerometry parameters and subjective variables did not demonstrate relevant correlation.
Monitoring the Carbonation-Induced Microcracking in Alkali-Activated Slag (AAS) by Nonlinear Resonant Acoustic Spectroscopy (NRAS)
Authors: Ghahramani Sara , Guan Yingjun , Radlińska Aleksandra , Shokouhi Parisa 
Published: October 2018

Abstract
This article presents the potential of nonlinear resonant acoustic spectroscopy (NRAS) for noninvasive monitoring of the carbonation progress in alkali-activated slag (AAS) mortars. In the search for sustainable concrete, AAS has emerged as a potential substitute for ordinary portland cement binder. However, carbonation is reported to be an important durability concern for AAS due to the absence of portlandite. In this study, the correspondence between the physical properties and microstructural evolution of sodium silicate-activated slag (SS-AS) and sodium hydroxide-activated slag (SH-AS) mortars were studied over the full course of accelerated carbonation. The measured properties include the following: compressive strength, carbonation depth, porosity, pore size distribution, and phase assemblage. In addition, NRAS was used to track the changes in materials stiffness (linear resonance frequency) and hysteretic nonlinearity (amplitude dependency of resonance frequency). Scanning electron microscopy (SEM) images and porosimetry results showed the formation of microcracks and increased micrometer porosity in a carbonated AAS binder caused by calcium aluminum silicate hydrate decalcification; the cracking was more severe in the SS-AS than in the SH-AS. The NRAS results revealed a close correspondence between the observed microscopic changes in the samples and measured macroscopic test parameters, indicating the potential of acoustic techniques for monitoring the advancement of carbonation fronts in AAS mortars.
A Direct-Push Crosshole (DPCH) Test Method for the In Situ Evaluation of High-Resolution P- and S-Wave Velocities
Authors: Cox Brady R. , Stolte Andrew C. , Stokoe Kenneth H. , Wotherspoon Liam M. 
Published: October 2018

Abstract
The direct-push crosshole (DPCH) test is a new, invasive, near-surface seismic testing method. DPCH combines the desirable characteristics of borehole-based crosshole seismic testing with the relative inexpensiveness and speed of direct-push testing methods like cone penetration testing (CPT). At each measurement depth (typically every 20–50 cm), compression (P) and shear (S) waves are generated simultaneously using hammer taps on one of the CPT push rods (a pushable, in-ground seismic source can also be used). These P- and S-waves are propagated between two instrumented seismic cones (i.e., a source and receiver cone). The instrumented cones contain a sensor package with three orthogonally oriented geophones to measure the seismic waveforms and a MEMS accelerometer to track the deviation/position of each cone as it is advanced into the ground. DPCH testing enables high-resolution profiles of P- and S-wave velocity to be measured over the top 20–30 meters of the subsurface for use in geotechnical engineering analyses. It also allows for testing across/through ground improvement elements like stone columns. The DPCH instrumentation, testing methodology, and data reduction techniques are explained in detail in this article, and results from several sites are discussed.
Fatigue and Corrosion Fatigue Properties of Additive-Manufactured Nickel Alloy 625 and Ti-6Al-4V
Authors: Hack Harvey , Olig Scott , Knudsen Erik , Link Richard , Beckwith Adelina , Arcari Attilio 
Published: October 2018

Abstract
Specimen blanks of additive-manufactured nickel Alloy 625 and Ti-6Al-4V were produced by the laser powder-bed-fusion process (L-PBF) with the principal test axis in both the Z direction (parallel to the build direction) and the X-Y direction (perpendicular to the build direction). The high cycle fatigue and corrosion fatigue properties of these metals were measured using R. R. Moore rotating cantilever fatigue tests, both in air and with a salt water drip on the test sections. Testing was conducted in order to determine the fatigue and corrosion fatigue limits of these materials at 108 cycles. The fatigue limit for L-PBF Alloy 625 material at 108 cycles in air was roughly 48 ksi (331 MPa), independent of build orientation. This is similar to the air fatigue limit of wrought material. The corrosion fatigue limit for L-PBF Alloy 625 material at 108 cycles in salt water was roughly 39 ksi (269 MPa), which was also independent of build orientation and slightly below the values for wrought material and values obtained by other investigators. The fatigue limit for hot isostatic pressed L-PBF Ti-6Al-4V material at 108 cycles in air was roughly 90 ksi (620 MPa), independent of build orientation. This is significantly better than the air fatigue limit of wrought material. The corrosion fatigue limit for L-PBF Ti-6Al-4V material at 108 cycles in salt water was roughly 78 ksi (540 MPa), which was also independent of build orientation, better than values for wrought material, and comparable to values obtained by other investigators. The fatigue crack growth rate behavior in air was characterized and compared with information available in the literature.
Cavitation Erosion Resistance Assessment and Comparison of Three Francis Turbine Runner Materials
Authors: Ylönen Markku , Saarenrinne Pentti , Miettinen Juha , Franc Jean-Pierre , Fivel Marc , Nyyssönen Tuomo 
Published: October 2018

Abstract
Cavitation erosion is the most important erosion mechanism in Francis turbine runner blades. For this reason, knowledge of a material’s ability to resist cavitation is important in defining how suitable it is for use in a Francis turbine. In this study, three Francis turbine materials were subjected to cavitation erosion in a high-speed cavitation tunnel. One of the materials was a low-alloy steel, and the other two were stainless steels. The cavitation tunnel produced an annular cavitation field on one face of a cylindrical specimen. The test specimens underwent cavitation erosion until the erosion had reached a maximum penetration depth of about 0.5 mm. The material surface profiles were measured at regular intervals to calculate volume and mass loss. These losses were compared to those of several other materials that had undergone the same tests with the same setup and operational parameters. The materials were compared according to their steady-state erosion rates. The steady-state erosion rate represents a material’s ability to resist cavitation erosion once cavitation damage has already started to develop. The low-alloy steel eroded four times faster than the two stainless steels. One of the stainless steels tested here (Stainless steel 1) had the lowest erosion rate, along with another previously tested stainless steel. The other stainless steel (Stainless steel 2) had a slightly greater erosion rate than the first, falling into the same class as other lower-grade stainless steels and a nickel aluminum bronze alloy. The results show that in choosing a turbine blade material, stainless steels outperform nonstainless ones. The choice of which type of stainless steel to use is significant in turbines with cavitation problems. The eroded surfaces were analyzed with scanning electron microscopy in order to study the erosion mechanisms, and these studies showed that most of the damage is probably due to low-cycle fatigue.
Recommended Procedures to Test the Resistance of Materials to Cavitation Erosion
Authors: Chahine Georges L. 
Published: October 2018

Abstract
Predicting cavitation erosion under full-scale operating conditions is difficult and relies on laboratory testing using accelerated methods such as ASTM G32-09, Standard Test Method for Cavitation Erosion Using Vibratory Apparatus, and ASTM G134-95, Standard Test Method for Erosion of Solid Materials by a Cavitating Liquid Jet. The main difficulty is that full-scale cavitation intensity is often unknown, and correlating cavitation field characteristics of the accelerated method and the full scale is not obvious. The problem is more acute for compliant polymeric coatings, used for protection or repair of parts subject to cavitation. Extensive testing of such materials shows that, unlike metallic surfaces, they are highly resistant to low-intensity cavitation but fail catastrophically when the intensity exceeds a certain threshold. Such behavior creates the risk of accepting a candidate coating for its resistance to cavitation if the coating was tested at a low cavitation intensity not representative of the application field conditions. This highlights the need to conduct tests with a range of cavitation intensities rather than a single intensity. This article uses results from extensive tests under various forms of cavitation to propose a generalized definition of cavitation intensity. It then presents data on the response of both metals and polymeric coatings to various levels of accelerated cavitation. A new method to test the coatings at varying cavitation intensities is then presented. Such tests provide maps of material resistance to different levels of cavitation and are helpful to make an informed decision. The tests also show that during cavitation exposure, the coatings are subjected not only to mechanical stress but also to significant heating, which dynamically modifies their properties during the exposure. Temperature rise in the coating when exposed to cavitation is directly connected to the cavitation intensity to which it is exposed, and this interaction needs to be considered.
Selective Loss of Thin Spines in Area 7a of the Primate Intraparietal Sulcus Predicts Age-Related Working Memory Impairment
Authors: Motley Sarah E. , Grossman Yael S. , Janssen William G.M. , Baxter Mark G. , Rapp Peter R. , Dumitriu Dani , Morrison John H. 
Published: October 2018

Brodmann area 7a of the parietal cortex is active during working memory tasks in humans and nonhuman primates, but the composition and density of dendritic spines in area 7a and their relevance both to working memory and cognitive aging remain unexplored. Aged monkeys have impaired working memory, and we have previously shown that this age-induced cognitive impairment is partially mediated by a loss of thin spines in prefrontal cortex area 46, a critical area for working memory. Because area 46 is reciprocally connected with area 7a of the parietal cortex and 7a mediates visual attention integration, we hypothesized that thin spine density in area 7a would correlate with working memory performance as well. To investigate the synaptic profile of area 7a and its relevance to working memory and cognitive aging, we investigated differences in spine type and density in layer III pyramidal cells of area 7a in young and aged, male and female rhesus macaques (Macaca mulatta) that were cognitively assessed using the delayed response test of working memory. Area 7a shows age-related loss of thin spines, and thin spine density positively correlates with delayed response performance in aged monkeys. In contrast, these cells show no age-related changes in dendritic length or branching. These changes mirror age-related changes in area 46 but are distinct from other neocortical regions, such as V1. These findings support our hypothesis that cognitive aging is driven primarily by synaptic changes, and more specifically by changes in thin spines, in key association areas.SIGNIFICANCE STATEMENTThis study advances our understanding of cognitive aging by demonstrating the relevance of area 7a thin spines to working memory performance. This study is the first to look at cognitive aging in the intraparietal sulcus, and also the first to report spine or dendritic measures for area 7a in either young adult or aged nonhuman primates. These results contribute to the hypothesis that thin spines support working memory performance and confirm our prior observation that cognitive aging is driven by synaptic changes rather than changes in dendritic morphology or neuron death. Importantly, these data show that age-related working memory changes are not limited to disruptions of the prefrontal cortex but also include an association region heavily interconnected with prefrontal cortex.
Specifying a Causal Role for Angular Gyrus in Autobiographical Memory
Authors: Bonnici Heidi M. , Cheke Lucy G. , Green Deborah A.E. , FitzGerald Thomas H.M.B. , Simons Jon S. 
Published: October 2018

Considerable recent evidence indicates that angular gyrus dysfunction in humans does not result in amnesia, but does impair a number of aspects of episodic memory. Patients with parietal lobe lesions have been reported to exhibit a deficit when freely recalling autobiographical events from their pasts, but can remember details of the events when recall is cued by specific questions. In apparent contradiction, inhibitory brain stimulation targeting angular gyrus in healthy volunteers has been found to have no effect on free recall or cued recall of word pairs. The present study sought to resolve this inconsistency by testing free and cued recall of both autobiographical memories and word-pair memories in the same healthy male and female human participants following continuous theta burst stimulation (cTBS) of angular gyrus and a vertex control location. Angular gyrus cTBS resulted in a selective reduction in the free recall, but not cued recall, of autobiographical memories, whereas free and cued recall of word-pair memories were unaffected. Additionally, participants reported fewer autobiographical episodes as being experienced from a first-person perspective following angular gyrus cTBS. The findings add to a growing body of evidence that a function of angular gyrus within the network of brain regions responsible for episodic recollection is to integrate memory features within an egocentric framework into the kind of first-person perspective representation that enables the subjective experience of remembering events from our personal pasts.SIGNIFICANCE STATEMENTIn seeking to understand the role played by the angular gyrus region of parietal cortex in human memory, interpreting the often conflicting findings from neuroimaging and neuropsychology studies has been hampered by differences in anatomical specificity and localization between methods. In the present study, we address these limitations using continuous theta burst stimulation in healthy volunteers to disrupt function of angular gyrus and a vertex control region. With this method, we adjudicate between two competing theories of parietal lobe function, finding evidence that is inconsistent with an attentional role for angular gyrus in memory, supporting instead an account in terms of integrating memory features within an egocentric framework into a first-person perspective representation that enables the subjective experience of remembering.
Deficiency of AMPAR–Palmitoylation Aggravates Seizure Susceptibility
Authors: Itoh Masayuki , Yamashita Mariko , Kaneko Masaki , Okuno Hiroyuki , Abe Manabu , Yamazaki Maya , Natsume Rie , Yamada Daisuke , Kaizuka Toshie , Suwa Reiko , Sakimura Kenji , Sekiguchi Masayuki , Wada Keiji , Hoshino Mikio , Mishina Masayoshi , Hayashi Takashi 
Published: October 2018

Synaptic AMPAR expression controls the strength of excitatory synaptic transmission and plasticity. An excess of synaptic AMPARs leads to epilepsy in response to seizure-inducible stimulation. The appropriate regulation of AMPARs plays a crucial role in the maintenance of the excitatory/inhibitory synaptic balance; however, the detailed mechanisms underlying epilepsy remain unclear. Our previous studies have revealed that a key modification of AMPAR trafficking to and from postsynaptic membranes is the reversible, posttranslationalS-palmitoylation at the C-termini of receptors. To clarify the role of palmitoylation-dependent regulation of AMPARsin vivo, we generated GluA1 palmitoylation-deficient (Cys811 to Ser substitution) knock-in mice. These mutant male mice showed elevated seizure susceptibility and seizure-induced neuronal activity without impairments in synaptic transmission, gross brain structure, or behavior at the basal level. Disruption of the palmitoylation site was accompanied by upregulated GluA1 phosphorylation at Ser831, but not at Ser845, in the hippocampus and increased GluA1 protein expression in the cortex. Furthermore, GluA1 palmitoylation suppressed excessive spine enlargement above a certain size after LTP. Our findings indicate that an abnormality in GluA1 palmitoylation can lead to hyperexcitability in the cerebrum, which negatively affects the maintenance of network stability, resulting in epileptic seizures.SIGNIFICANCE STATEMENTAMPARs predominantly mediate excitatory synaptic transmission. AMPARs are regulated in a posttranslational, palmitoylation-dependent manner in excitatory synapses of the mammalian brain. Reversible palmitoylation dynamically controls synaptic expression and intracellular trafficking of the receptors. Here, we generated GluA1 palmitoylation-deficient knock-in mice to clarify the role of AMPAR palmitoylationin vivo. We showed that an abnormality in GluA1 palmitoylation led to hyperexcitability, resulting in epileptic seizure. This is the first identification of a specific palmitoylated protein critical for the seizure-suppressing process. Our data also provide insight into how predicted receptors such as AMPARs can effectively preserve network stability in the brain. Furthermore, these findings help to define novel key targets for developing anti-epileptic drugs.
Encoding of Reward and Decoding Movement from the Frontal Eye Field during Smooth Pursuit Eye Movements
Authors: Lixenberg Adi , Joshua Mati 
Published: October 2018

Expectation of reward potentiates sensorimotor transformations to drive vigorous movements. One of the main challenges in studying reward is to determine how representations of reward interact with the computations that drive behavior. We recorded activity in smooth pursuit neurons in the frontal eye field (FEF) of two male rhesus monkeys while controlling the eye speed by manipulating either reward size or target speed. The neurons encoded the different reward conditions more strongly than the different target speed conditions. This pattern could not be explained by differences in the eye speed, since the eye speed sensitivity of the neurons was also larger for the reward conditions. Pooling the responses by the preferred direction of the neurons attenuated the reward modulation and led to a tighter association between neural activity and behavior. Therefore, a plausible decoder such as the population vector could explain how the FEF both drives behavior and encodes reward beyond behavior.SIGNIFICANCE STATEMENTMotor areas combine sensory and reward information to drive movement. To disambiguate these sources, we manipulated the speed of smooth pursuit eye movements by controlling either the size of the reward or the speed of the visual motion signals. We found that the relationship between activity in frontal eye field and eye kinematics varied: the eye speed sensitivity was larger for the different reward conditions than for the different target speed conditions. Decoders that pooled signals by the preferred direction of the neurons attenuated the reward modulations. These decoders may indicate how reward can be both encoded beyond eye kinematics at the single neuron level and drive movement at the population level.