bluuebunny/crossref_metadata_2025_split huggingface dataset:
PERBEDAAN ASUPAN ZAT GIZI PASIEN HEMODIALISA DI RSUD dr. DORIS SYLVANUS PALANGKA RAYA
Authors: Dewi Fretika Utami 
Published: October 2019

ABSTRACT
Background: Hemodialysis is a catabolic process (breakdown of complex compounds into simpler compounds) in which amino acid removal and protein synthesis depletion occurred.
Objective: To investigate differences in nutritional intake of hemodialysis patients at RSUD dr. Doris Sylvanus Palangka Raya.
Research Methodology: This research is an observational research with Pre-post design. Purposive sampling technique was employed on 13 PGK patients who undertake weekly hemodialysis at RSUD dr. Doris Sylvanus Palangka Raya. Data of protein, sodium, potassium and oral intakes were obtained by interview and 24-hour food recall for 2 consecutive days of pre and post hemodialysis. BM photo book was used during interview and food recall. Data were analyzed using paired t-test.
Result of the study: Most of samples were female (92%), ranged at 46-67 years old, graduated from elementary school and not working. Bivariate test showed p value of protein, sodium, potassium and fluid intakes were 0.022, 0.382, 0.075 and 0.836, respectively. Hemodialysis aims to restrain uremia, excessive fluid and electrolyte imbalance that occur in end-stage renal failure patients. Hemodialysis may increase survival rate of patients as it is effectively removing fluids, electrolytes and metabolites.
Conclusion: There was a significant difference in protein intake and insignificant differences in sodium, potassium and fluid intakes of pre and post hemodialysis patients at RSUD dr. Doris Sylvanus Palangka Raya.
THE EFFECT OF SURVEY, QUESTION, READ, RECITE, AND REVIEW (SQ3R) TEACHING METHOD AND READING INTEREST TOWARD READING COMPREHENSIONS OF CHILDREN STORIES ABILITY (EXPERIMEN RESEARCH IN THE 5th GRADE OF ELEMENTARY SCHOOL AT LAWEYAN DISTRICTS SURAKARTA
Authors: Husna Miftakhul , Slamet St. Y. , Poerwanti Jenny Indrastoeti Siti 
Published: October 2019

<em>The purpose of this research 1) The difference of reading comprehensions of children stories ability that taught by SQ3R teaching method within CIRC teaching method, 2) The difference of reading comprehensions of children stories ability between students who had high interest in reading and students who had low interest in reading, 3) The interaction between teaching method and reading interes. This research used quasi experimental method with randomized contract group pretest-postest used factorial 2x2 design. The result of this research showed that: 1) There was the difference of reading comprehensions of children stories ability that teach SQ3R teaching method and students who were taught by CIRC teaching method 2 ) there was the difference of between students who had high interest in reading and students who had low interest in reading 3) There was interaction between teaching method and reading interest</em>
THE IMPLEMENTATION OF THE 21TH CENTURY COMPETENCY FOR ELEMENTARY SCHOOL TEACHERS AT CURRICULUM 2013 TRAINING CENTRAL JAVA PROVINCE YEAR 2017
Authors: Harjanti Mulida Hadrina 
Published: October 2019

<p><em>The purpose of writing this paper is; 1) to understand methods and strategies in applying 21st century competency (4C = critical thinking, creative thinking, communication, and collaborative) and; 2) to show the results of the competence of 21st century elementary school teachers in training curriculum 2013. The method used in this research is descriptive qualitative method. The results and discussion of this paper is the strategy of training in the application of 21st century competence and Strengthening Character Education. first teacher show and give exemplary to the character and competence of the 21st century. The role of teachers as examples must be highlighted. If you want to teach the character, then the teacher must first display their character. While the results of the application of 21st century competence and Strengthening Character Education after the 2013 curriculum training can be shown by increasing the achievement of the quality report cards on the competency standards of graduates, content, process, and assessment standards. </em></p>
DEVELOPMENT MODELOF TRADITIONAL GAME (GONTENG) AS PHYSICAL EDUCATION LEARNING IN CHARACTER BUILDING FOR UPPER CLASS ELEMENTARY SCHOOL STUDENTS
Authors: Widodo Puput , Widiyono Ibnu Prasetyo , Iriawan Yogi Ferdy 
Published: October 2019

<p><em>The study was conducted through two stages: (1) pre-development stage, which includes; (a) review of relevant literature and research, and (b) field studies, (2) the development stage,which includes; (a) drafting, (b) validation expert, (c) testing of small-scale models, (d) testing large-scale models, and (e) of the final product.The small-scale tryout was conducted by involving 30 students of upper grades. The large-scale tryout was conducted by involving 130 students of upper grades. The data collecting instruments were an interview guideline, a questionnaire to assess characters of traditional games, a questionnaire to assess the traditional game development, a questionnaire for the assessment by the media expert, and a questionnaire for the evaluation by students. Based on the assessment by experts andteachers of physical, sports, and health education, it was concluded that the developed models of traditional games were effective to be used in the learning for the students of upper grades.</em></p>
ANALYSIS OF THEMATIC LEARNING IN THE 2013 CURRICULUM SDN 7 KEBUMEN
Authors: Rahayu Teguh , Putri Kurnia Wardani , Umifaiqoh Isnaeniatun , Suryandari Kartika Chrysti 
Published: October 2019

<em>The policy of applying the 2013 curriculum has an impact on the implementation of thematic learning. This study aims to describe the application of thematic learning in SDN 7 Kebumen. This study uses descriptive qualitative methods. The subjects of this study were teacher of class I and teacher of class IV, 5 studens of class I and 5 students of class IV. The students were taken from students with high, medium and low abilities. Data collection techniques are carried out through observation, interviews, and questionnaires. Data analysis techniques used are source triangulation and technical triangulation The results of this study prove that the application of thematic learning has been running in accordance with the 2013 curriculum, teachers and students respond well to the application of thematic learning. But there are still a few obstacles. Among them are apperception and motivation are less memorable for students. Thus, it can be concluded that the implementation of thematic learning class I and IV in SDN 7 Kebumen is in accordance with the 2013 curriculum, but there needs to be an increase in apperception and motivation.</em>
DEVELOPMENT OF ECO-CULTURE TO IMPROVE ENVIROMENTAL LITERACY IN ELEMENTARY SCHOOL
Authors: Agsari Karenina Shashal , Rahady Mayang Kusumaning , Wahyudi Wahyudi 
Published: October 2019

<p><em>The objectives of writing scientific papers are: (1) describing eco-culture, (2) describing ecoliteration of the environment, and (3)to describing ways to improve environmental ecoliteracy by means of eco-culture in elementary schools. The method used is literature study, which is data collection techniques by conducting study studies of books, literature, notes, and reports that are related to the problem being solved. Library sources in this study were obtained from: books, journals and research results (thesis, thesis, and dissertation). So that in this study include general processes such as: systematic theory identification, library discovery, and documentary analysis which contains information relating to the research topic. The results of this study are (1) eco-culture a process of increasing understanding, knowledge, attitudes and behavior based on ecology. (2) environmental echoliteration is to teach children to love the environment through greening. (3) improve environmental ecoliteracy in primary schools by take care and practicing directly maintaining and caring for the school environment.</em></p>
Penerapan Strategi Pembelajaran Point-Counterpoint Bervariasi untuk Meningkatkan Daya Kritis dan Hasil Belajar pada Mata Pelajaran PKn Topik Usaha Pembelaan Negara Bagi Siswa Kelas IX E SMP Negeri 1 Mojosongo
Authors: Suwadi Suwadi 
Published: October 2019

The objective of this research “The application of Point- Counterpoint Variety” is to increase the students’ creativity capable and the outcome of Pkn subject with “Pembelaan Negara” topic for the students of IX E SMPN 1 Mojosongo the first semester academic year 2013/ 2014. This research using qualitative method with descriptive feature, describe the data and interprise the data. The kind of this research is action research (PTK) that was done by the researcher directly. The setting of this reseach is IXE class SMP N 1 Mojosongo the first semester academic year 2013/2014 which has low capable from one of the sevent classses paralel. The technic of collecting the data are test and non test. For collecting the data using the observation and the items of test. To know the efectiveness the process of learning using the strategy “Point-CounterPoint Variety”, the researcher and the collaborator have done the observation in the process of learning. While the validity of the data using content validity and triangulasi. The analysis of the data using the analysis descriptive comparative and qualitative. Indicators which be hope in this research are : 1) Increase the students’ critical capacity from 13,33% (before treatment) become 26,00 % in the 1st cycle, and 35,00 % in 2nd cycle; 2) Increase the students’ average 71,90 (before tretment) in the 1St cycle to 80,00 in the 1nd cycle and 85,00 in the 2 nd cycle. After the process of collected and analised the data, the result of the research is significant. This result show that the strategy of learning Point-counterpoint variety can improve :1) The students’s critical capacity 13,33% ( before treatment) to 28,57% in the 1st cycle, and 41,90% in the 2nd cycle. 2) The students’ average 71,90 (before treatment) to 86,67 in the 1st cycle, and 92,14 in the 2rd cycle. Increase the critical capacity and the outcome for “Pendidikan Kewarganegaraan” with topic “Usaha Pembelaan Negara” for the students IXE class SMP Negeri 1 Mojosongo the first semester academic year 2013/2014.
The gut microbiota profile of adults with kidney disease: A systematic review of the literature
Authors: Stanford Jordan , Charlton Karen , Stefoska-Needham Anita , Ibrahim Rukayat , Lambert Kelly 
Published: October 2019

Abstract
Background

There is mounting evidence that individuals with kidney disease have an abnormal gut microbiota composition. No studies to date have summarised the evidence to categorise how the gut microbiota profile of individuals with kidney disease may differ from healthy controls. Synthesis of this evidence is important to inform future clinical trials. This systematic review aims to characterise differences of the gut microbiota composition in adults with kidney disease, as well as to describe the functional capacity of the gut microbiota and reporting of diet as a confounder in these studies.

Methods

Included studies were those that investigated the gut microbial community in adults with any type of kidney disease and compared this to the profile of healthy controls. Six scientific databases (CINHAL, Medline, PubMed, Scopus, Web of Science, Cochrane Library) as well as selected grey literature sources were searched up until August 2018. Quality assessment was undertaken independently by three authors. The system of evidence level criteria was employed to quantitatively evaluate the alteration of microbiota by strictly considering the number, methodological quality and consistency of the findings. Additional findings relating to altered functions of the gut microbiota, dietary intakes and dietary methodologies used were qualitatively summarised.

Results

Sixteen articles, reporting 15 studies met the eligibility criteria and included a total of 540 adults with kidney disease and 1117 healthy controls. Compared to healthy controls, individuals with kidney disease had increased abundances of Enterobacteriaceae, and decreased abundances of Coprococcus and Prevotella. Adults with kidney stones also had an altered microbial composition with variations to Bacteroides, Lachnospiraceae NK4A136 group, Ruminiclostridium 5 group, Dorea, Enterobacter, Christensenellaceae and its genus Christensenellaceae R7 group. Altered microbial functions in adults with kidney disease were reported, particularly in the context of metabolic pathways relating to urea and uremic toxin generation. Only three of the 16 articles accounted for diet, and of these studies only two used a valid dietary assessment method.

Conclusions

The gut microbiota profile of adults with kidney disease differs from healthy controls. Future study designs should include adequate reporting of important confounders such as dietary intakes to assist with interpretation of findings.
Transcriptomic analysis of Verbena bonariensis roots in response to cadmium stress
Authors: Wang Meng-qi , Bai Zhen-yu , Xiao Ya-fang , Li Yan , Liu Qing-lin , Zhang Lei , Pan Yuan-zhi , Jiang Bei-bei , Zhang Fan 
Published: October 2019

Abstract
Background: Cadmium (Cd) is a serious heavy metal (HM) soil pollutant. To alleviate or even eliminate HM pollution in soil, environmental-friendly methods are applied. One is that special plants are cultivated to absorb the HM in the contaminated soil. As an excellent economical plant with ornamental value and sound adaptability, V.bonariensis could be adapted to this very situation. In our study, the Cd tolerance in V.bonariensis was analyzed as well as overall analysis of transcriptome.
Results: In this study, the tolerance of V.bonariensis to Cd stress was investigated in four aspects: germination, development, pysiological changes, and molecular alterations. The results showed that as a non-hyperaccumulator, V. bonariensis did possess the Cd tolerance and the capability to concentration Cd. Under Cd stress, all 237,866 transcripts and 191,370 unigenes were constructed in the transcriptome data of V.bonariensis roots . The enrichment analysis of gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway revealed that differentially expressed genes (DEGs) under Cd stress were predominately related to cell structure, reactive oxygen species (ROS) scavenging system, chelating reaction and secondary metabolites, transpiration and photosynthesis. DEGs encoding lignin synthesis, chalcone synthase (CHS) and anthocyanidin synthase (ANS) were prominent in V. bonariensis under Cd stress. The expression patterns of 10 DEGs, validated by quantitative real-time polymerase chain reaction (qRT-PCR), were in highly accordance with the RNA-Sequence (RNA-Seq) results. The novel strategies brought by our study was not only benefit for further studies on the tolerance of Cd and functional genomics in V. bonariensis , but also for the improvement molecular breeding and phytoremediation.
Association Of Childhood Socioeconomic Status With Edentulism Among Chinese In Mid-Late Adulthood
Authors: ZHANG XIAONING , CHEN SHUANG 
Published: October 2019

Abstract
Objectives The purpose of this study was to examine the association between childhood socioeconomic status (SES) and edentulism using directed acyclic graphs (DAGs) for the selection of confounders , and after adjusting for childhood health, adult SES, adult health-related behaviors and father’s health-related behaviors. Methods Chinese respondents in a Health and Retirement Longitudinal Study (CHARLS) were assessed at age 45 and 59 years. Childhood SES was determined using the father’s education, parents’ occupation, father’s working status, family’s financial situation, self-perceived childhood health, relationship with the father, mother’s effort to care for her child, mother’s love and affection, parents quarrel and fight, residential community safety, primary residence, neighbors’ help, neighborhood relation, enough food availability and access to medical care and convenience. Father’ health-related behaviors were established by taking into account smoking and drinking habits. Childhood health was determined by considering childhood hospitalization and self-perceived childhood health status. Adult SES was established based on adulthood educational achievements. Adult health-related behaviors were determined by taking into account smoking and drinking habits, as well as physical activities and sleep time. Edentulism was determined using self-reported lost all of teeth . The mediators were selected using DAGs, cross-tabulation and binary logistic regression models based on DAGs. Model assessment of the regression equation was evaluated by Hosmer-Lemeshow goodness-of-fit test. Results Data from a total of 7,459 respondents were available, 140 of whom were edentulous (1.9%). The prevalence of edentulism at ages 45 and 59 years was substantially higher among those with low childhood SES. In all adjusted models based on DAGs, edentulism was negatively associated with father’s occupation as farmer (OR = 5.7, 95% CI = 1.3–25.0) and neighbor’s unwillingness to help (OR = 4.9, 95% CI = 1.6–15.4). Conclusion Childhood SES was associated with the prevalence of edentulism among middle-aged Chinese adults, whereas the father’s occupation, and neighbor’s help were negatively associated with edentulism . The experiences in early life associated with low SES contributes to poor dental health. Therefore, more attention needs to be paid to childhood SES in order to determine optimal recommendations and develop more effective intervention strategies.
Distinct molecular etiologies of male and female hepatocellular carcinoma
Authors: Natri Heini M , Wilson Melissa A , Buetow Kenneth H 
Published: October 2019

Abstract
Background: Sex-differences in cancer occurrence and mortality are evident across tumor types; men exhibit higher rates of incidence and often poorer responses to treatment. Targeted approaches to the treatment of tumors that account for these sex-differences require the characterization and understanding of the fundamental biological mechanisms that differentiate them. Hepatocellular Carcinoma (HCC) is the second leading cause of cancer death worldwide, with the incidence rapidly rising. HCC exhibits a male-bias in occurrence and mortality, but previous studies have failed to explore the sex-specific dysregulation of gene expression in HCC.
Methods: Here, we characterize the sex-shared and sex-specific regulatory changes in HCC tumors in the TCGA LIHC cohort using combined and sex-stratified differential expression and eQTL analyses.
Results: By using a sex-specific differential expression analysis of tumor and tumor-adjacent samples, we uncovered etiologically relevant genes and pathways differentiating male and female HCC. While both sexes exhibited activation of pathways related to apoptosis and cell cycle, males and females differed in the activation of several signaling pathways, with females showing PPAR pathway enrichment while males showed PI3K, 305 PI3K/AKT, FGFR, EGFR, NGF, GF1R, Rap1, DAP12, and IL-2 signaling pathway enrichment. Using eQTL analyses, we discovered germline variants with differential effects on tumor gene expression between the sexes. 24.3% of the discovered eQTLs exhibit differential effects between the sexes, illustrating the substantial role of sex in modifying the effects of eQTLs in HCC. The genes that showed sex-specific dysregulation in tumors and those that harbored a sex-specific eQTL converge in clinically relevant pathways, suggesting that the molecular etiologies of male and female HCC are partially driven by differential genetic effects on gene expression.
Conclusions: Sex-stratified analyses detect sex-specific molecular etiologies of HCC. Overall, our results provide new insight into the role of inherited genetic regulation of transcription in modulating sex-differences in HCC etiology and provide a framework for future studies on sex-biased cancers.
Socio-demographic characteristics and co-occurrence of depressive symptoms with chronic diseases among older adults in China: the China Longitudinal Ageing Social Survey
Authors: Wang Zhenjie , Yang Hanmo , Guo Zhanyuan , Liu Bei , Geng Shen 
Published: October 2019

Abstract
Background: The aim of the current study is to assess the cross-sectional association of chronic non-communicable diseases (hypertension, diabetes mellitus, arthritis, and cerebrovascular) with depressive symptoms among older adults in China.
Methods: Data was obtained from the China Longitudinal Ageing Social Survey (CLASS) conducted in 2014. A total of 7505 participants were included. Depressive symptoms status was assessed by 9-item Center for Epidemiological Studies Depression Scale (CES-D) Associations between depressive symptoms and chronic diseases, adjusting for so, demographics and chronic diseases risk factors were assessed by using logistic regression model.
Results: We found negative associations between depressive symptoms and several socioeconomic factors, including education attainment and economic level. Widowed/divorced/ unmarried individuals are more likely to suffer from depressive symptoms. Hypertension (Odds ratio:1.29 [95%CI:1.16, 1.42]), diabetes (1.41 [95%CI:1.19,1.67]), arthritis (1.72 [1.52, 1.96]), and cerebrovascular disease (1.69 [1.41, 2.02]) were found to be associated with depressive symptoms.
Conclusions: Most depressive symptoms cases were found to be significantly associated with chronic diseases. Our findings have provided evidence for understanding co-morbid depressive symptoms with chronic diseases, which could help clinicians to evaluate, diagnose and manage depression promptly.