bluuebunny/crossref_metadata_2025_split huggingface dataset:
Experimental and Numerical Simulation on the Generation and Development of Cumulative Plastic Strain of Cement Sheath in Salt Cavern Gas Storage Well
Authors: Ren Zhenkun , Xi Yan , Jiang Hailong , Li Qian , Li Qing 
Published: December 2024

ABSTRACTSalt cavern gas storage is an important technical means to balance the demand for staggered energy supply. Due to the repeated injection and extraction of natural gas in gas storage facilities, sealing integrity failure in the wellbore of gas storage facilities frequently occurs. In response to this, considering the cyclic loading and unloading of the pressure load inside the casing, mechanical tests of set cement were carried out under alternating loads, quantifying the cumulative plastic strain change law of set cement and revealing the deterioration characteristics of its mechanical properties. A numerical model of cumulative plastic strain of casing cement sheath formation under alternating load was established based on the obtained experimental parameters. Comparative verification was conducted using experimental data, and the variation law of cumulative plastic strain of cement sheath was analyzed. The distribution of cumulative plastic strain on the cement sheath bonding surface of the entire wellbore was quantified. The research results indicate that the higher the internal pressure value of the casing, the earlier the plastic strain appears, and with the increase in the number of alternating loads, the cumulative plastic strain increases approximately linearly. After the internal pressure increased by 30 MPa, the cumulative plastic strain increased by a maximum of 46.75%. When the number of loading and unloading cycles under alternating loads is small, reducing the elastic modulus (6 GPa) of the cement sheath can effectively reduce its cumulative plastic strain. However, as the number of loading and unloading cycles under alternating loads exceeds a specific value, the cumulative plastic strain produced by high elastic modulus (15 GPa) cement sheaths decreases. Finally, the distribution pattern of cumulative plastic strain along the wellbore under different gas injection times and complex formation conditions was analyzed. Suggestions for establishing well barriers in salt cavern gas storage during cementing were proposed. The research results can provide theoretical and engineering references for evaluating the sealing integrity of gas storage wells.
Exploring the Impact of Dietary Factors on Intestinal Diverticular Disease: A Mendelian Randomization Approach
Authors: Tian Wangzhao , Yang Wenwen , Wang Xiaorui , Yang Yanjiang 
Published: December 2024

ABSTRACTDietary habits significantly influence the development of intestinal diverticular disease (IDD), a common gastrointestinal condition primarily affecting the colon. We performed a Mendelian randomization (MR) analysis on 20 diet‐related factors using data from the UK Biobank. IDD cases (n = 33,618) and controls (n = 329,381) were obtained from the FinnGen Biobank. Three key MR methods were applied: the inverse‐variance‐weighted (IVW) method as the primary approach to estimate causal relationships, along with the weighted median (WM) and MR‐Egger methods. Significant associations were found for pork intake (β = 1.06, p = 0.00244), nonoily fish intake (β = 0.709, p = 0.0449), oily fish intake (β = 0.246, p = 0.0222), and dried fruit intake (β = −0.953, p < 0.0001). After false discovery rate (FDR) adjustment, pork intake (q = 0.0244) and dried fruit intake (q < 0.0001) remained significant. Our results indicate that while pork and certain types of fish intake may elevate the risk of IDD, dried fruit intake may offer a protective effect. These findings highlight the potential of dietary changes in IDD prevention and management, though further research across diverse populations is needed.
Elucidating the Causal Impact of Dietary Factors on Rheumatoid Arthritis: Insights From Multivariable Mendelian Randomization Analysis
Authors: Lu Yun , Su Qiang , Xie Zhongbo , Liang Jiang 
Published: December 2024

ABSTRACTRheumatoid arthritis (RA) is a common chronic autoimmune disorder with an incompletely elucidated pathogenesis. Emerging research indicates that dietary factors may significantly influence the onset and progression of RA. Nevertheless, the causal relationship between dietary habits and RA remains ambiguous. This investigation employed a multivariable Mendelian randomization (MVMR) methodology to rigorously assess the potential causal effects of various dietary factors on RA risk. This study utilized genome‐wide association study (GWAS) summary‐level data, encompassing dietary preferences (n = 113,425–159,579), and RA data (n = 302,614) from the most recent FinnGen database. The primary causal analysis was conducted using inverse‐variance weighting (IVW), complemented by MR‐Egger, weighted median, Bayesian weighted Mendelian randomization, and Robust Adjusted Profile Score (RAPS) methodologies. Sensitivity analyses incorporated Cochran's Q test, MR‐Egger intercept test, MR‐PRESSO, and leave‐one‐out analysis. Steiger tests were employed to evaluate the identified dietary preferences. MVMR was utilized to assess the direct impact of dietary factors on RA. The study identified significant associations between RA and nine dietary preferences: F‐lentils/beans liking (Fle), chips liking (Chips), coffee difference liking (CD), coffee with sugar liking (CWS), milk chocolate liking (MC), coriander liking (Coriander), pollock liking (Pollock), soft cheese liking (SC), and blue cheese liking (BC). The MVMR analysis indicated that genetically predicted coriander and MC have a direct impact on RA, independent of other dietary factors. This study presents novel causal evidence suggesting that dietary preferences may impact the risk of RA. Specifically, a reduction in the consumption of milk chocolate and coriander may contribute to the prevention and alleviation of RA. However, additional research is required to elucidate the underlying mechanisms and to validate these findings across diverse populations.
How clinical exposure improves dental students' understanding of oral and maxillofacial surgery: A cross‐sectional study
Authors: Joachim Michael V. , Tabib Rami , Shapiro Ephraim , Laviv Amir 
Published: December 2024

AbstractPurposeTo assess dental students' understanding of oral and maxillofacial surgery (OMFS) practice areas and examine changes in referral preferences across their educational progression in Israel.MethodsA cross‐sectional survey was conducted among 349 dental students from two Israeli universities (46.5% response rate). The primary independent variable was the year of study (pre‐clinical vs. clinical years). The main outcome variables included perceptions of OMFS scope and referral preferences for various procedures. Covariates included demographics and prior OMFS exposure. Chi‐square tests, linear trend analysis, and mediation analysis were performed.ResultsStudents in clinical years exhibited a broader understanding of OMFS scope compared to pre‐clinical years. Referral preferences to OMFS increased significantly for complex procedures like facial skeletal deformities (46.2% to 61.3%, p = 0.004) and oral cancer (66.2% to 78.9%, p = 0.008). The perception of extractions as the primary OMFS procedure increased from 63.6% in the first year to 77.6% in the sixth year (p = 0.033). Personal and family experiences with OMFS significantly mediated the relationship between year of study and referral tendencies (16.2% of total effect mediated, p < 0.001).ConclusionClinical exposure improves understanding of OMFS capabilities, leading to increased referrals for complex procedures. However, several practice areas remain underrecognized, highlighting the need for improved educational interventions.
Experiences of individuals receiving “Not Parent Expected” results through direct‐to‐consumer genetic testing
Authors: Becker Julia , Abrams Liane J. , Weil Jon , Youngblom Janey 
Published: December 2024

AbstractAs direct‐to‐consumer genetic testing (DTC‐GT) grows in popularity, the unanticipated “Not Parent Expected” (NPE) result has become more prevalent. An NPE result is the discovery that one parent, often the father, is not a biological parent. This study explores the impact of making an NPE discovery through DTC‐GT. Twenty‐five participants were interviewed and transcripts were analyzed using thematic analysis. NPE discovery had an impact on participants' personal identity. They frequently reported having experienced grief and loss among other emotions whether the discovery confirmed a participant's prior suspicions or was unexpected. Strained parent/child relationships prior to the NPE discovery and further negative impact on the relationship after DTC‐GC were common themes. Connection to newly identified biological parents and family was a common goal reported by many participants, with mixed outcomes of such connections. Further research will assist in deepening our understanding and confirming the findings of this study.
Sex differences in atrial fibrillation in India: Insights from the Kerala‐AF registry
Authors: Calvert Peter , Chen Yang , Gue Ying , Gupta Dhiraj , Azariah Jinbert Lordson , George Koshy A. , Zachariah Geevar , Natarajan K. U. , Lip Gregory Y. H. , Gopalan Bahuleyan Charantharayil ,   the Kerala AF Registry Investigators
Published: December 2024

AbstractBackgroundMuch data informing sex differences in atrial fibrillation (AF) comes from Western cohorts. In this analysis, we describe sex differences in Kerala, India, using the Kerala‐AF registry—the largest AF registry from the Indian subcontinent.MethodsPatients aged ≥18 years were recruited from 53 hospitals across Kerala. Patients were compared for demographics, treatments, and 12‐month outcomes, including major adverse cardiovascular events (MACE) and bleeding.ResultsMale patients were more likely to have a smoking and/or alcohol history and had more ischaemic heart disease (46.2% vs. 25.5%; p < 0.001). Female patients had more valvular AF (35.1% vs. 18.0%; p < 0.001), and more use of calcium‐channel blockers (23.3% vs. 16.5%; p < 0.001) or digoxin (39.6% vs. 28.5%; p < 0.001). Almost one in four patients were not anticoagulated despite raised CHA2DS2‐VASc scores. 12‐month MACE outcomes did not differ by sex (male: 30.2% vs. female: 29.4%; p = 0.685), though bleeding events were more common in male patients (2.4% vs. 1.3%; p = −0.038), driven by minor bleeding (1.2% vs. 0.5%).ConclusionIn this large AF cohort from India, male patients had a higher prevalence of ischaemic heart disease, smoking, and alcohol use, while female patients had a higher prevalence of valvular heart disease. MACE did not differ by sex, though bleeding was more common in males. Almost a quarter of patients were not anticoagulated despite raised thromboembolic risk.
Fortified bread with encapsulated ingredients: impacts and potential applications
Authors: Samakar Bahareh , Tajani Amineh Sadat , Fazly Bazzaz Bibi Sedigheh , Soheili Vahid 
Published: December 2024

AbstractWaste production is a major challenge in the food industry. The use of ‘functional food’ by adding bioactive compounds is a promising solution to reduce it. However, many bioactive compounds are unstable when subjected to industrial and environmental conditions. Microencapsulation technology is a useful method to preserve these molecules. This review categorizes microencapsulated functional bread additives, including enzymes, salts, alcohols, oils, herbal compounds, probiotics, and acids, and demonstrates various beneficial effects of these additives. Suitable wall materials and encapsulating techniques – including freeze drying, spray drying, the emulsion‐congealing method, fluidized bed coating, and thin‐film hydration methods – are discussed in terms of their effect on bread quality. The encapsulated bread ingredients and their impact on bread characteristics are investigated by examining relevant original and review studies from various electronic databases, irrespective of publication date. © 2024 Society of Chemical Industry.
Textbook Outcomes and Quality of Life Assessment Following Liver Resection for Colorectal Metastasis
Authors: McGarry Jennifer Louise , Quirke Ned , Neary Colm , Walsh Ruth , O'Connell Robert Michael , McEntee Gerry , Conneely John Barry 
Published: December 2024

ABSTRACTBackgroundIt is unknown if textbook outcomes (TBOs) correlate with patient‐reported health‐related quality of life (HRQoL) parameters in patients undergoing hepatic resection for colorectal liver metastasises. Understanding this relationship is required to inform treatment decisions and optimise patient care. This single‐centre analysis aims to assess this correlation and provide insight into the impact of liver resection on patient well‐being in this population.MethodsSingle‐centre analysis of all liver resections performed for colorectal liver metastases (CRLM) at our centre from 2018 to 2023. The EuroQol‐5D (EQ‐5D) validated telephone questionnaire was used to assess HRQoL. The impact of a TBO on overall survival and recurrence‐free survival was investigated using Kaplan−Meier curve analysis. A Cox model was used to determine factors associated with improved survival.Results185 patients underwent liver resection for CRLM between 2018 and 2023. 55% of eligible patients completed the EQ‐5D telephone questionnaire. TBOs were achieved in 68.2% of CRLM at our institution. Achieving TBOs in this cohort was associated with improved HRQoL (p = 0.061).ConclusionThis study demonstrates excellent long‐term HRQoL in patients who undergo resection for CRLM. Achieving TBO in this cohort is associated with improved patient‐reported HRQoL. Our findings strengthen the utility of the previously defined textbook outcomes in CRLM.
Correlating Double‐Cone Polariton Dynamics with Local Femtosecond Laser Modifications in Ultrashort‐Pulse‐Stimulated Crystals
Authors: Wang Lei , Zheng Jia‐Xin , Cui Lin , Wang Hai‐Yu , Liu Xue‐Qing , Luo Yang , Chen Qi‐Dai , Sun Hong‐Bo 
Published: December 2024

AbstractStrong similarities for relativistic electrons stimulated from electron beams and electron clouds are merging the boundary of wave‐particle duality of electrons, one of which being superposition is Cherenkov radiations. Recent theoretical investigations into quantum Cherenkov effects for cone‐shape particles have hypothesized electron‐spin flip transitions in bound‐ and free‐electron systems like bulk silica and graphene. However, experimental validation of these predictions remains outstanding. Here, analogous phenomena of polariton‐version quantum Cherenkov radiations observed by broadband femtosecond pump‐probe experiments is reported, and demonstrate double‐cone emission processes involving of Cherenkov‐type phonon polaritons (PhPs) and plasmon‐PhPs in ultrashort‐pulse‐stimulated ferroelectric crystals and graphene, respectively. Through component analysis of double‐cone polariton emissions using an empirical quantum dynamics model, the initial polariton dynamics are restored by time translation corrections. The resulting quantum wave packets of PhPs are found to be correlated with femtosecond‐laser‐induced modifications inside ferroelectric lithium niobates, achieving a PhP threshold criterion for ultrasmooth femtosecond laser nanofabrication.
Quasi‐Bound States in the Continuum on Dislocated Bilayer Metal Gratings for Spatiotemporal Vortex Pulse Generation
Authors: Zhou Yi , Zou Renwei , Zhan Junjie , Wang Yubo , Dai Daoxin , Choudhury Pankaj K. , Forbes Andrew , Ma Yungui 
Published: December 2024

AbstractSpatiotemporal vortex pulses (STVPs) with transverse orbital angular momentum (OAM) have recently stimulated great interest, influencing wide disciplines from classical to quantum optics. However, generating sophisticated STVPs in high‐efficiency and compact systems remains a challenge. This work outlines an ultra‐compact metasurface approach to efficiently generate STVPs through the coupling of free‐space plane waves with a quasi‐bound state in the continuum (quasi‐BIC). The approach leverages external excitation of the quasi‐BIC at the Γ‐point by slightly dislocating two sub‐layer gratings to break the mirror symmetries. This operation converts the incident wave into a unidirectional surface mode and induces a Fano resonance, resulting in STVPs in the frequency‐momentum domain. The method is demonstrated experimentally with a meta‐grating to produce an electromagnetic (EM) STVP with a topological charge of l = −1 with high fidelity and use the set‐up to unravel the hitherto unexplored diffraction and dispersive properties of near‐field STVPs. The present work can be extended from the microwave to the visible light regime by simply scaling the metasurface, and allowing high‐order OAM generation through cascaded elements, thereby paving a robust way to build up ultra‐compact STVP multiplexing devices for future applications.
Ultrafast Room‐Temperature Synthesis of Yb3+/Er3+ Codoped K3ZrF7 Nanocrystals for Thermal Enhancement of Upconversion
Authors: Fu Huhui , Xie Wenfeng , Qian Yuanqi , Li Xiao , Zhang Yaning , Lu Jingbing , Xiong Qi , Wu Anhua , Su Liangbi , Liu M. 
Published: December 2024

AbstractLanthanide (Ln3+)‐doped upconversion nanocrystals (NCs) have attracted great attention due to their outstanding luminescent performance and wide applications in various fields. However, the preparation of most Ln3+‐doped NCs requires rigorous conditions such as high reaction temperature, long reaction time, strict anhydrous and oxygen‐free environment, and tedious post‐treatment process. Herein, sub‐100 nm Yb3+/Er3+ codoped K3ZrF7 octahedral NCs are prepared by an extremely simple coprecipitation method (10 s only at room temperature). The resulting NCs show excellent upconversion luminescence (UCL), significantly superior to both their conventional high‐temperature‐synthesized counterparts and the room‐temperature‐synthesized NaBiF4:Yb/Er controls. More importantly, abnormal thermally enhanced UCL over a temperature range from room temperature to 473 K is found in these K3ZrF7:Yb/Er NCs, making them promising candidates for ratiometric thermometry applications. By employing the luminescence intensity ratio between two non‐thermally coupled energy levels of Er3+, namely 4F9/2 and 2H11/2, these NCs display an extraordinarily high absolute sensitivity of 443.2% K−1 and a comparatively large relative sensitivity of 1.55% K−1 at room temperature. These results reveal that K3ZrF7:Yb/Er NCs can not only be facilely prepared via an ultrafast room‐temperature synthesis, but also hold great potential in various areas such as optical temperature sensing and biological applications.
Enhancing Sensitivity of Piezoresistive Pressure Sensor at Low Pressures Using Photo‐Sensitive Resin Plate as Flexible Substrate
Authors: Akrami Ferdos , Hamedi Samaneh 
Published: December 2024

AbstractIn this paper, flexible highly sensitive piezoresistive pressure sensors for low compressive stress detection (9.8 Pa to 10.7 kPa) are proposed, by using Photo‐Sensitive Resin Plate (PSRP). The photolithography method is employed to create the micro‐dome structure pattern on PSRP. Finally, the active parts of the sensors are made by depositing a thin layer of silver (Ag), as the sensing element, on the micro‐dome patterns. Herein, the effect of three different surface pattern dimensions as well as two different thicknesses of the Ag layer on sensor sensitivity are evaluated. The sensor fabricated with a diameter of 300 µm for micro‐dome structure, and 70 nm for the thickness of Ag layer demonstrated ultrahigh sensitivity of 29343 and 5 × 106 kPa−1 in the pressure ranges of 0.2–5 and 5–10.7 kPa, respectively. The sensor with a diameter of 300 µm for micro‐domes and an Ag‐thickness layer of 100 nm has a low working voltage of 0.1 V, a high sensitivity of 223.69 kPa−1 in the pressure range <0.11 kPa, and lowest limit of detection 9.8 Pa. The response and recovery times of this sensor are 270 and 60 ms, respectively. Furthermore, the sensor maintained high and stable performance over a 17‐min period.
Cord Blood Transplantation Using Myeloablative Conditioning for Pediatric Advanced Myelodysplastic Syndrome in AMeD Syndrome With a Novel ADH5 Variant
Authors: Morishita Yusuke , Hamada Motoharu , Uemura Suguru , Kikuchi Hiroaki , Hisakawa Hiroaki , Fujikawa Tomoko , Tamura Akihiro , Okuno Yusuke , Wakamatsu Manabu , Muramatsu Hideki , Takahashi Yoshiyuki , Hasegawa Daiichiro , Kosaka Yoshiyuki 
Published: December 2024

ABSTRACTAplastic anemia, mental retardation, and dwarfism syndrome (AMeDS) is a rare inherited bone marrow failure syndrome. Allogeneic hematopoietic stem cell transplantation (allo‐HSCT) is the only possible treatment option for hematological complications in AMeDS; however, there are no reports addressing allo‐HSCT for AMeDS. A 6‐year‐old female diagnosed with AMeDS accompanying myelodysplastic syndrome with increased blast was successfully treated with cord blood transplantation followed by myeloablative conditioning (MAC). A novel ADH5 c.1101‐3C>G variant detected in this patient was demonstrated to be a null variant causing several patterns of alternative splicing in ADH5 gene. MAC might be feasible and effective in AMeDS.
Evaluating the Prognostic Impact of Apparent Diffusion Coefficient in Definitive Radiotherapy for Gleason Score 7 Prostate Cancer Patients
Authors: Onal Cem , Elmali Aysenur , Erbay Gurcan , Demirhan Birhan , Sutera Philip , Deek Matthew P. , Tran Phuoc T. , Guler Ozan Cem 
Published: December 2024

ABSTRACTBackgroundTo investigate the utility of diffusion‐weighted magnetic resonance imaging (DW‐MRI) in evaluating Gleason score (GS) 7 tumors before definitive radiotherapy (RT) and to explore its association with clinicopathological factors and treatment outcomes.Materials and MethodsClinical data of 266 prostate cancer (PCa) patients with biopsy‐confirmed GS 7 who underwent RT were retrospectively analyzed. Pretreatment DW‐MRI was utilized to measure apparent diffusion coefficient (ADC) values of primary tumors. Treatment outcomes, including biochemical disease‐free survival (bDFS) and prostate cancer‐specific survival (PCSS), were assessed. Statistical analyses were conducted to determine the correlation between tumor ADC values, clinicopathological factors, and treatment outcomes.ResultsTumors with a GS of 3 + 4 had significantly higher ADC values than those with a GS of 4 + 3 (0.746 ± 0.150 vs. 0.702 ± 0.157 × 10−³ mm²/s; p < 0.001). Median follow‐up time was 8.6 years, and the 7‐year rates for bDFS and PCSS were 89.1% and 95.3%, respectively. Lower tumor ADC values were significantly correlated with higher GS and increased risk of disease progression. A primary tumor ADC cutoff value of 0.682 × 10−³ mm²/s was identified for predicting disease progression. Patients with higher ADC values exhibited significantly better 7‐year bDFS rates (92.8% vs. 83.2%; p = 0.02). However, GS 4 + 3 tumors independently predicted poorer bDFS and PCSS outcomes. In the multivariable analysis, only GS 4 + 3 tumor was predictive for worse bDFS and PCSS.ConclusionsTumor ADC values are a reliable biomarker for differentiating between GS 3 + 4 and 4 + 3 tumors in the GS 7 category. Tumors exhibiting lower ADC values have been associated to higher risk factors and an increased likelihood of disease progression, particularly in GS 3 + 4 tumors where GS upgrading could happen.