bluuebunny/crossref_metadata_2025_split huggingface dataset:
Complex interventions of abdominal aorta and its branches in children with Takayasu arteritis: Clinical experience from a tertiary care center in north‐west India
Authors: Vijayvergiya Rajesh , Jindal Ankur K. , Pilania Rakesh K. , Suri Deepti , Gupta Anju , Sharma Ashish , Sinha Saroj K. , Singhal Manphool , Bahl Ajay , Singh Surjit 
Published: November 2018

AbstractAimTo report our experience on complex percutaneous interventions of the abdominal aorta and its branches in six children with Takayasu arteritis (TA).MethodsA review of records of children with TA, who underwent percutaneous interventions of the abdominal aorta and its major branches.ResultsIn this analysis, we included six children with TA who underwent intervention of the abdominal aorta and its major branches. The endovascular interventions were performed mostly for treatment‐resistant renovascular hypertension and mesentery artery ischemia. Mean age (±SD) at time of intervention was 10.6 ± 2.5 years (four boys and two girls). Percutaneous interventions included stenting of abdominal aorta (n = 2), renal arteries (n = 4), mesenteric arteries (n = 2), repeat stenting for renal artery in‐stent restenosis (n = 1), and renal autotransplantation (n = 4). All 13 interventions were successful and enabled us to obtain good control of blood pressure.ConclusionWe hereby report six children with TA who were successfully managed with complex percutaneous interventions of the abdominal aorta and its major branches. Balloon dilatation and stent placement constitutes the mainstay of management of TA with stenosis of the large vessels.
Musculoskeletal symptoms and disorders among 350 garment workers in Bangladesh: A cross‐sectional pilot study
Authors: Shazzad Md. Nahiduzzamane , Ahmed Shamim , Haq Syed Atiqul , Islam Md. Nazrul , Abu Shahin Md. , Choudhury Minhaj Rahim , Hasan Abu Tahir Muhammad Tanveer , Abdal Syed Jamil , Rasker Johannes Jacobus 
Published: November 2018

AbstractObjectiveTo study the prevalence of musculoskeletal (MSK) symptoms and disorders among garment workers in Bangladesh, to look for possible relationships between pain location and type of work performed and to estimate the prevalence of rheumatological diagnoses.MethodsA cross‐sectional pilot study among 350 garment workers using the COPCORD (Community Oriented Program for Control of Rheumatic Disorders) methodology. Subjects with musculoskeletal pain were examined by rheumatologists for rheumatological diagnosis. The workers were classified into cutting, sewing, finishing and quality control operators.ResultsMost of the workers were aged below 35 years (88%) and females (82.9%) and the majority had only primary education (74.6%). The prevalence of MSK pain within 7 days of the interview was 77.1%, a much higher figure than in the general population. The most affected sites were: shoulder (17.9%), lower back (15.2%), neck (13.8%) and knee (10.8%). Multiple regional pain was the commonest finding in 173 of 350 workers. In this pilot study rheumatoid arthritis was diagnosed in 0.9%, undifferentiated arthritis in 1.1%, nonspecific low back pain in 4.6%, soft tissue rheumatism in 3.7%, osteoarthritis in 0.9% and lumbar spondylosis in 1.1%, figures comparable with those observed in the general population; spondyloarthropathy was seen more often, in 1.42%, possibly explained by the small numbers.ConclusionsMusculoskeletal pains are common among garment workers of Bangladesh and may cause morbidity, disability, and work loss. Our findings may be important to plan ergonomic measures preventing complaints and may be of interest for international companies ordering garments in Bangladesh.
Development of the Asia Pacific Lupus Collaboration cohort
Authors: Kandane‐Rathnayake Rangi , Golder Vera , Louthrenoo Worawit , Luo Shue‐Fen , Jan Wu Yeong‐Jian , Li Zhanguo , An Yuan , Lateef Aisha , Sockalingam Sargunan , Navarra Sandra V. , Zamora Leonid , Hamijoyo Laniyati , Katsumata Yasuhiro , Harigai Masayoshi , Chan Madelynn , O’Neill Sean , Goldblatt Fiona , Hao Yanjie , Zhang Zhuoli , Al‐Saleh Jamal , Khamashta Munther , Takeuchi Tsutomu , Tanaka Yoshiya , Bae Sang‐Cheol , Lau Chak Sing , Hoi Alberta , Nikpour Mandana , Morand Eric F. 
Published: November 2018

AbstractAimThe aim of this manuscript is to describe the development of the Asia Pacific Lupus Collaboration (APLC) cohort.MethodThe APLC cohort is an ongoing, prospective longitudinal cohort. Adult patients who meet either the American College of Rheumatology (ACR) Modified Classification Criteria for systemic lupus erythematosus (SLE), or the Systemic Lupus International Collaborating Clinics (SLICC) Classification Criteria, and provide informed consent are recruited into the cohort. Patients are routinely followed up at 3‐ to 6‐monthly intervals. Information on demographics, clinical manifestations, treatment, pathology results, outcomes, and patient‐reported quality of life (Short‐form 36 version 2) are collected using a standardized case report form. Each site is responsible for obtaining local ethics and governance approval, patient recruitment, data collection, and data transfer into a centralized APLC database.ResultsThe latest APLC cohort comprises 2160 patients with >12 000 visits from Australia, China, Hong Kong, Indonesia, Japan, Malaysia, Philippines, Singapore, Taiwan and Thailand. The APLC has proposed the Lupus Low Disease Activity State (LLDAS) as a treat‐to‐target (T2T) endpoint, and reported several retrospective and cross‐sectional analyses consistent with the validity of LLDAS. Longitudinal validation of LLDAS as a T2T endpoint is currently underway.ConclusionThe APLC cohort is one of the largest contemporary SLE patient cohorts in the world. It is the only cohort with substantial representation of Asian patients. This cohort represents a unique resource for future clinical research including evaluation of other endpoints and quality of care.
Randomized trial of acupuncture with antiemetics for reducing postoperative nausea in children
Authors: Martin Christine S. , Deverman Sarah E. , Norvell Daniel C. , Cusick Jordan C. , Kendrick Angela , Koh Jeffrey 
Published: November 2018

BackgroundPostoperative nausea and vomiting (PONV) is common after tonsillectomy in children. There is evidence that perioperative acupuncture at the pericardium 6 (P6) point is effective for preventing PONV in adults. Our goal was to determine if intraoperative acupuncture at the P6 point, in addition to usual antiemetics, is more effective than antiemetics alone in preventing PONV in children.MethodsIn a randomized double‐blind trial, 161 children age 3 through 9 years undergoing tonsillectomy with or without adenoidectomy were randomized to either bilateral acupuncture at P6 plus antiemetics (n = 86) or antiemetics only (n = 75). All participants received ondansetron 0.15 mg/kg and dexamethasone 0.25 mg/kg, up to 10 mg. The presence of nausea, retching, emesis and administration of additional antiemetics were recorded during phases I and II of PACU recovery. Follow‐up calls occurred on postoperative day 1 (POD 1).ResultDuring phase I and II recovery, the incidence of PONV was significantly less with acupuncture than without (7.0% vs 34.7%, RR: 0.2, 95% CI: 0.09‐0.46; P < 0.001). The difference in PONV was driven by less nausea in the acupuncture group (5.0% vs 24.0%), with no difference in vomiting between the two groups. In the first 24 hours, PONV occurred in 36.1% with acupuncture and 49.3% without; these values did not differ significantly (P = 0.09).ConclusionsChildren receiving acupuncture plus antiemetic therapy had less risk of developing nausea during phase I and II recovery, but there was no difference in PONV on POD 1. Acupuncture may reduce nausea in the PACU, even when combined with antiemetics.
Long‐term mortality and cause of death for patients treated in Intensive Care Units due to poisoning
Authors: Lindqvist Elin , Edman Gunnar , Hollenberg Jacob , Nordberg Per , Forsberg Sune 
Published: November 2018

BackgroundPoisoned patients treated in the Intensive Care Unit are common, representing up to 6% of all ICU admissions. The in‐hospital mortality is generally low but little is known about the long‐term mortality in these patients. The aim of this study was to describe long‐term mortality and cause of death in patients treated in the ICU for poisoning.MethodA national observational study based on three registers: the National Patient Register, the Swedish Intensive Care Register and the Cause of Death Register. All patients ≥19 years admitted to a Swedish Intensive Care Unit between January 1, 2010 and December 31, 2011 with an ICD‐10 code for poisoning were included.ResultsA total of 6730 patients were included. The one‐year mortality was 4.5% (n = 303), with an overweight of men among the deceased (59.1%, P = 0.002). Patients aged 19‐39 years had a 48 times increased one‐year mortality compared to the age‐matched general population and 94% of these patients died from suicide and/or accident, of which 70% were from a new poisoning. The two‐year mortality was 7.2%. Women have a slightly higher overall long‐term survival over two years (P< 0.001).ConclusionThe risk of premature death is markedly increased in younger patients one and two years after an ICU hospitalisation for non‐fatal poisoning compared to the general population. A large majority die due to a new poisoning incident despite a previously known recent severe poisoning.Editorial commentAdmission to ICU with poisoning, and particularly self‐poisoning, may be associated with long‐term mortaliity. In this study of 6730 patients admitted to a Swedish ICU for poisoning, the in‐hospital mortality was low for that admission, but there is an increased risk of later mortality in young patients one and two years after hospital discharge.
Overexpression of ASIC1A in the nucleus accumbens of rats potentiates cocaine‐seeking behavior
Authors: Gutman Andrea L. , Cosme Caitlin V. , Noterman Maria F. , Worth Wensday R. , Wemmie John A. , LaLumiere Ryan T. 
Published: November 2018

AbstractAcid‐sensing ion channels (ASICs) are abundantly expressed in the nucleus accumbens core (NAcore), a region of the mesolimbocortical system that has an established role in regulating drug‐seeking behavior. Previous work shows that a single dose of cocaine reduced the AMPA‐to‐NMDA ratio in Asic1a−/− mice, an effect observed after withdrawal in wild‐type mice, whereas ASIC1A overexpression in the NAcore of rats decreases cocaine self‐administration. However, whether ASIC1A overexpression in the NAcore alters measures of drug‐seeking behavior after the self‐administration period is unknown. To examine this issue, the ASIC1A subunit was overexpressed in male Sprague‐Dawley rats by injecting them with adeno‐associated virus, targeted at the NAcore, after completion of 2 weeks of cocaine or food self‐administration. After 21 days of homecage abstinence, rats underwent a cue‐/context‐driven drug/food‐seeking test, followed by extinction training and then drug/food‐primed, cued, and cued + drug/food‐primed reinstatement tests. The results indicate that ASIC1A overexpression in the NAcore enhanced cue‐/context‐driven cocaine seeking, cocaine‐primed reinstatement, and cued + cocaine‐primed reinstatement but had no effect on food‐seeking behavior, indicating a selective effect for ASIC1A in the processes underlying extinction and cocaine‐seeking behavior.
The evolving drug epidemic of prescription opioid injection and its association with HCV transmission among people who inject drugs in Montréal, Canada
Authors: Bruneau Julie , Arruda Nelson , Zang Geng , Jutras‐Aswad Didier , Roy Élise 
Published: November 2018

AbstractAimsTo examine temporal trends in prescription opioid (PO) injection and to assess its association with hepatitis C virus (HCV) seroconversion among people who inject drugs (PWID).DesignProspective cohort study spanning 2004 to 2016.SettingMontréal, Canada.ParticipantsPWID reporting injection during the past 6 months.MeasurementsPWID were recruited between 2004 and 2016. At each 3–6‐month follow‐up visit, participants completed interview‐administered questionnaires and were tested for HCV‐antibody.FindingsAmong 1524 PWID [83% males, mean age 38 years, standard deviation (SD) = 10, 34% (31–36) prescription opioid (PO) injection past month] included in trends analyses, PO injection use expanded between 2004 and 2009, and plateaued between 2010 and 2016 (trend tests < 0.001 and 0.335, respectively). Of the 432 HCV‐seronegative PWIDs followed at least once (81% males, mean age 34, SD 9.8, 38% injection PO), 153 became HCV‐antibody‐positive during 1230 years of follow‐up, for an incidence of 12.4 per 100 person‐years [95% confidence interval (CI) = 10.6, 14.6]. PO injectors were 3.9 times more likely to seroconvert to HCV, relative to non‐PO injectors. In a multivariate analysis, a stronger association between PO injection and HCV seroconversion was found post‐2009 [adjusted hazard ratio (aHR) = 5.4, 95% CI = 2.7, 10.8] than before (aHR = 1.5, 95% CI = 0.9, 2.4) (P‐value for interaction = 0.001).ConclusionPrescription opioid injection increased among people who inject drugs in Montréal, Canada from 2004 to 2009, to reach a plateau between 2010 and 2016. The association between prescription opioid injection and HCV seroconversion was stronger during the second period than the first according to the epidemic phase.
Effects of rumen‐protected methionine on milk production in early lactation dairy cattle fed with a diet containing 14.5% crude protein
Authors: Tamura Tetsuo , Inoue Kazunori , Nishiki Hideto , Sakata Masafumi , Seki Makoto , Koga Teruaki , Ookubo Yoshihiro , Akutsu Kazuhiro , Sato Say , Saitou Kouichi , Shinohara Hikari , Kuraisi Terumi , Kajikawa Hiroshi , Kurihara Mitsunori 
Published: November 2018

AbstractWe evaluated the influence on milk production of feeding early lactation cows a diet that included 14.5% crude protein (CP) and that did not meet methionine (Met) requirements or that met them by supplying rumen‐protected Met (RPMet). Thirty‐nine multiparous Holstein cows were allocated into two groups. For 15 weeks after calving, each group was fed one of the two total mixed rations, Control (n = 20) or Treatment (n = 19). The Treatment group received added RPMet at 0.034% (8 g/day) of the Control diet on dry matter basis. The adequacies of Met for the Control and Treatment groups were 96% and 106%, respectively, and for other amino acids, >110%. The CP level (14.5%) was 1 percentage point lower than that recommended by the Japanese Feeding Standard (2006). No between‐group differences were found in milk yield (40 kg/day), milk composition, plasma profile, rumen fermentation, nitrogen balance, or cow health. Met intake and the amount of rumen‐undegradable feed Met were higher in the Treatment group (p < 0.05). Microbial Met and total metabolizable Met did not differ between groups. Supplying RPMet in a 14.5% CP diet during early lactation did not dramatically affect milk production, because the amount of total metabolizable Met was unchanged.
Effects of simulated microgravity on the expression profiles of RNA during osteogenic differentiation of human bone marrow mesenchymal stem cells
Authors: Li Liang , Zhang Cui , Chen Jian‐ling , Hong Fan‐fan , Chen Ping , Wang Jin‐fu 
Published: November 2018

AbstractObjectivesExposure to microgravity induces many adaptive and pathological changes in human bone marrow mesenchymal stem cells (hBMSCs). However, the underlying mechanisms of these changes are poorly understood. We revealed the gene expression patterns of hBMSCs under normal ground (NG) and simulated microgravity (SMG), which showed an interpretation for these changes by gene regulation and signal pathways analysis.Materials and methodsIn this study, hBMSCs were osteogenically induced for 0, 2, 7 and 14 days under normal ground gravity and simulated microgravity, followed by analysis of the differences in transcriptome expression during osteogenic differentiation by RNA sequencing and some experimental verification for these results.ResultsThe results indicated that 837, 399 and 894 differentially expressed genes (DEGs) were identified in 2, 7 and 14 days samples, respectively, out of which 13 genes were selected for qRT‐PCR analysis to confirm the RNA‐sequencing results. After analysis, we found that proliferation was inhibited in the early stage of induction. In the middle stage, osteogenic differentiation was inhibited, whereas adipogenic differentiation benefited from SMG. Moreover, SMG resulted in the up‐regulation of genes specific for tumorigenesis in the later stage.ConclusionOur data revealed that SMG inhibits the proliferation and inhibits the differentiation towards osteoblasts but promotes adipogenesis. SMG also selects highly tumorigenic cells for survival under prolonged SMG.
Recent progress in the emerging role of exosome in hepatocellular carcinoma
Authors: Abudoureyimu Mubalake , Zhou Hao , Zhi Yingru , Wang Ting , Feng Bing , Wang Rui , Chu Xiaoyuan 
Published: November 2018

AbstractExosomes are small membrane vesicles 50‐150 nm in diameter released by a variety of cells, which contain miRNAs, mRNAs and proteins with the potential to regulate signalling pathways in recipient cells. Exosomes deliver nucleic acids and proteins to participate in orchestrating cell‐cell communication and microenvironment modulation. In this review, we summarize recent progress in our understanding of the role of exosomes in hepatocellular carcinoma (HCC). This review focuses on recent studies on HCC exosomes, considering biogenesis, cargo and their effects on the development and progression of HCC, including chemoresistance, epithelial‐mesenchymal transition, angiogenesis, metastasis and immune response. Finally, we discuss the clinical application of exosomes as a therapeutic agent for HCC.
Instantaneous areal population density of entire Atlantic cod and herring spawning groups and group size distribution relative to total spawning population
Authors: Makris Nicholas C. , Godø Olav Rune , Yi Dong Hoon , Macaulay Gavin J. , Jain Ankita D. , Cho Byunggu , Gong Zheng , Jech Josef Michael , Ratilal Purnima 
Published: November 2018

AbstractThe wide‐area group behaviour of spawning Atlantic cod and herring is investigated. By a combination of Ocean Acoustic Waveguide Remote Sensing (OAWRS) and conventional sensing methods, first‐look images of the instantaneous population density are obtained of entire Atlantic cod spawning groups, stretching for tens of kilometres in the Nordic Seas. This structural information made it possible to quantify the spawning group size distribution of cod over a roughly 30‐year period from conventional line‐transect data acquired annually by vertical echo sounding in the Nordic Seas. The size distribution is found to be consistent with the log‐normal probability density often found in growth processes that depend on many independent parameters. Nordic Seas cod populations are found to distribute into many vast behavioural groups during spawning with relatively stable mean size despite larger variations in total annual population. When sustained at pre‐industrial levels, the total spawning population is found to greatly exceed the mean spawning group size. As an apparent consequence of this large differential, when the total population, or overall scale, declined to within a standard deviation of this mean cod spawning group quantum, or inner‐group‐behavioural scale, return to pre‐industrial levels required decades. Findings for Atlantic herring are similar, where summing the spawning group populations measured in a single instantaneous OAWRS image per day over the 8‐day peak spawning period enabled accurate enumeration of the entire Georges Bank herring spawning population to within 7% of the independent NOAA estimate for 2006. These results may be relevant to other oceanic fish.
Phylogenetics and diversity analysis of Pennisetum species using Hemarthria EST‐SSR markers
Authors: Zhou Sifan , Wang Chengran , Yin Guohua , Zhang Yu , Shen Xiaoyun , Pennerman Kayla K. , Zhang Jianbo , Yan Haidong , Zhang Chenglin , Zhang Xinquan , Ren Shuping , Guo Tianfeng , Peng Yan , Ma Xiao , Liu Wei , Yan Yanhong , Huang Linkai 
Published: November 2018

AbstractExpressed sequence tag‐simple sequence repeat (EST‐SSR) markers are widely applied in plant molecular genetics studies due to their abundance in the genome, codominant nature, and high repeatability. To study the genetic diversity of 35 accessions and transferability of EST‐SSR markers in cross‐species applications, 21 primer pairs previously developed in Hemarthria were amplified across Pennisetum species. A total of 148 polymorphisms were generated with an average of 7.05 bands per locus. The mean values of the genetic parameters polymorphism information content, number of bands, effective number of bands, Nei's gene diversity, and Shannon's information index were 0.8430, 2.0000, 1.7640, 0.4247 and 0.6132, respectively. Cluster analysis of 35 accessions divided them into three clusters, which were consistent with dendrograms of 14 species. The among‐population component explained most of the genetic diversity (66%); the remaining variation (34%) occurred within populations. This study will provide more available EST‐SSR markers for Pennisetum species, and facilitate studies on germplasm collection and utilization of Pennisetum species.
Use of cannabis and risk of advanced liver fibrosis in patients with chronic hepatitis C virus infection: A systematic review and meta‐analysis
Authors: Wijarnpreecha Karn , Panjawatanan Panadeekarn , Ungprasert Patompong 
Published: November 2018

AbstractObjectivesChronic hepatitis C virus (HCV) infection is one of the most common chronic liver diseases. Several risk factors for the progression of liver fibrosis among these patients have been identified. Use of cannabis could be another risk factor, but the results from epidemiological studies remain inconclusive.MethodsComprehensive literature review was conducted using MEDLINE and EMBASE databases through December 2017 to identify studies that compared the risk of advanced liver fibrosis among HCV‐infected patients who use and who do not use cannabis. Effect estimates from each study were extracted and combined together using the random‐effect, generic inverse variance method of DerSimonian and Laird.ResultsA total of three cohort studies with 898 participants met the eligibility criteria and were included in the meta‐analysis. The risk of advanced liver fibrosis among HCV‐infected patients who use cannabis was numerically higher than those who do not use cannabis, although the result did not achieve statistical significance (pooled odds ratio, 1.77; 95% confidence interval, 0.78–4.02). The statistical heterogeneity was high with an I2 of 75%.ConclusionsThis meta‐analysis showed that the risk of advanced liver fibrosis among HCV‐infected patients who use cannabis was higher than those who do not use cannabis, but the result was not statistically significant. Further studies are required to better characterize the risk.