bluuebunny/crossref_metadata_2025_split huggingface dataset:
Histogram analysis derived from apparent diffusion coefficient (ADC) is more sensitive to reflect serological parameters in myositis than conventional ADC analysis
Authors: Meyer Hans Jonas , Emmer Alexander , Kornhuber Malte , Surov Alexey 
Published: February 2018

Objective:
Diffusion-weighted imaging (DWI) has the potential of being able to reflect histopathology architecture. A novel imaging approach, namely histogram analysis, is used to further characterize tissues on MRI. The aim of this study was to correlate histogram parameters derived from apparent diffusion coefficient (ADC) maps with serological parameters in myositis.

Methods:
16 patients with autoimmune myositis were included in this retrospective study. DWI was obtained on a 1.5 T scanner by using the b -values of 0 and 1000 s mm– 2. Histogram analysis was performed as a whole muscle measurement by using a custom-made Matlab-based application. The following ADC histogram parameters were estimated: ADCmean, ADCmax, ADCmin, ADCmedian, ADCmode, and the following percentiles ADCp10, ADCp25, ADCp75, ADCp90, as well histogram parameters kurtosis, skewness, and entropy. In all patients, the blood sample was acquired within 3 days to the MRI. The following serological parameters were estimated: alanine aminotransferase, aspartate aminotransferase, creatine kinase, lactate dehydrogenase, C-reactive protein (CRP) and myoglobin. All patients were screened for Jo1-autobodies.

Results:
Kurtosis correlated inversely with CRP (p = –0.55 and 0.03). Furthermore, ADCp10 and ADCp90 values tended to correlate with creatine kinase (p = –0.43, 0.11, and p = –0.42, = 0.12 respectively). In addition, ADCmean, p10, p25, median, mode, and entropy were different between Jo1-positive and Jo1-negative patients.

Conclusion:
ADC histogram parameters are sensitive for detection of muscle alterations in myositis patients.

Advances in knowledge:
This study identified that kurtosis derived from ADC maps is associated with CRP in myositis patients. Furthermore, several ADC histogram parameters are statistically different between Jo1-positive and Jo1-negative patients.
Typification of the Linnaean name Staticelimonium (Plumbaginaceae)
Authors: Ferrer-Gallego P. Pablo , Rosselló Josep A. , Guacchio Emanuele Del , Iamonico Duilio 
Published: February 2018

AbstractThe typification of the Linnaean name Statice limonium (≡ Limonium vulgare) is discussed. Original material preserved at BM, LINN and UPS is heterogeneous and belongs to several species. The specimen at LINN (No. 395.3) is designated as the lectotype to preserve the current usage of the name.
<em>Bryophyllum pinnatum</em> leaves ethanol extract inhibit maturation and promote apoptosis of systemic lupus erythematosus BALB/c mice B cells
Authors: Handono Kusworini , Dantara Tri W.I. , Dewi Elvira S. , Pratama Mirza Z. , Nurdiana Nurdiana 
Published: February 2018

Background: B cells play a key role in systemic lupus erythematosus (SLE). Targeting B cells as SLE therapy is a plausible approach. This study investigated the potential effects of Bryophyllum pinnatum leaves with ethanol extract in decreasing percentages of maturation, increasing percentages of apoptosis, and decreasing NF-κB p65 expressions of SLE BALB/c mice B cells.Methods: Culturing B cells from pristane induced SLE BALB/c mice’s spleen will resulted in this in vitro study. B cells were activated by BAFF, LPS, IL-4, and anti-CD40 yielding CD19+ >80%. B cells were cultured by adding those stimulants with and without B. pinnatum leaves (0, 0.02, 0.1, or 0.5 µg/ml) for 72 hours at 37°C. Flow cytometry was performed to determine The Percentages of maturation (CD19+CD38+) and apoptosis (Annexin V+PI+) of B cells. Further analysis to determine the expressions of transcription factor of maturation and apoptosis of B cells, NF-ĸB p65, were performed using immunocytochemistry. Data were analyzed using SPSS version 22.Results: Flow cytometry assay showed significant decrease in percentages of maturation of B cells in all doses and significant increase in percentage of apoptosis of B cells in dose 0.5 µg/ml. Immunocytochemistry results showed significant decrease expressions of NF-ĸB p65 in all doses. Percentages of maturation, apoptosis, and expressions of NF-ĸB p65 of B cells were significantly correlated.Conclusion: This in vitro study revealed that B. pinnatum leaves with ethanol extract decreased the percentages of maturation, increased the percentage of apoptosis, and decreased NF-κB p65 expressions of SLE BALB/c mice B cells significantly.
Say My Name: Nameplate Jewelry and the Politics of Taste
Authors: Flower Isabel , Rosa-Salas Marcel 
Published: February 2018

Abstract
This essay is about the social and material history of nameplate jewelry and its significance in American culture. We argue that the nameplate is an object where conversations and contentions surrounding identity, style, and power converge. Whether it be a necklace, ring, or pair of earrings, the nameplate is both specific to the wearer and exemplary of a collective style, therefore existing in a space of simultaneous conformity and nonconformity. By examining the nameplate’s genesis in mass American culture, we will examine how the discourse surrounding the style’s ostensible “tackiness” is rooted in notions of taste and aesthetics that are shaped by hierarchical race, class and gender politics. Engaging with Bourdieu and Duchamp’s theories on taste, we show how the myriad forms the nameplate takes and the conversations about style that circulate around them reveal struggles of cultural dominance and appropriation. We will close with a discussion of how the expression of personhood can be a political act and claim to citizenship.
Digital Video as a Personalized Learning Assignment: A Qualitative Study of Student Authored Video using the ICSDR Model
Authors: Campbell Laurie O. , Cox Thomas 
Published: February 2018

Students within this study followed the ICSDR (Identify, Conceptualize/Connect, Storyboard, Develop, Review/Reflect /Revise) development model to create digital video, as a personalized and active learning assignment. The participants, graduate students in education, indicated that following the ICSDR framework for student authored video guided their video creation process, resulting in focus for their ideas, and increasing motivation to learn more about their content. Finally, the participants indicated that creating a digital video was an authentic and personalized learning experience that fostered personal choice and voice and peer collaboration. Evidence from the qualitative study supports students following a development framework for video creation.
Entornos virtuales para el aprendizaje: una mirada desde la teoría de los campos conceptuales
Authors: Araque Iralí , Montilla Lissette , Meleán Ramón , Arrieta Xiomara 
Published: February 2018

La inclusión de las tecnologías de la comunicación e información con fines formativos ha dado paso a los entornos virtuales de aprendizaje, los cuales, respaldados por teorías constructivistas, brindan un marco teórico y metodológico, contribuyendo así al desarrollo cognitivo de los estudiantes a nivel universitario, puesto de manifiesto en el desarrollo de sus esquemas de aprendizaje. La teoría de los campos conceptuales ofrece un análisis acerca de los elementos de los esquemas y del proceso de construcción de conocimientos. En este sentido, el presente trabajo tuvo como objetivo plantear algunos elementos, como la metodología de enseñanza, estrategias didácticas, materiales y recursos para el aprendizaje, roles del profesor y del estudiante, que deben considerarse en el diseño de los entornos virtuales de aprendizaje, a la luz de la teoría de los campos conceptuales, de modo que se potencie la construcción de conocimientos y donde el énfasis del proceso educativo recaiga sobre el aprendizaje más que en la enseñanza. La metodología utilizada es documental, de tipo descriptivo, fundamentada en la revisión y análisis bibliográfico de teorías constructivistas, así como investigaciones referidas al diseño y construcción de entornos virtuales de aprendizaje. Los resultados muestran que la teoría de los campos conceptuales es una excelente opción a considerar, como teoría constructivista, a fin de consolidar el proceso de construcción de conocimientos, desde lo individual hasta lo colectivo.
Desarrollo del conocimiento tecnológico y pedagógico del contenido de la química, de profesores en formación a través de la reflexión de los PaP-eRs y videos
Authors: Candela Boris Fernando 
Published: February 2018

En este artículo se describió cómo los profesores en formación identificaron y desarrollaron algunos elementos del conocimiento tecnológico y pedagógico del contenido de la química (CTPC), a lo largo del curso de contexto educativo y pedagógico por “orientación reflexiva”. La perspectiva metodológica fue cualitativa por estudio de casos, la cual estuvo configurada por dos ámbitos de reflexión entretejidos, a saber: a) reflexión sobre las opiniones de los expertos acerca de la enseñanza de un contenido, a través de las lecturas propuestas en los programas de formación, y b) reflexión acerca de la enseñanza, llevada a cabo por profesores experimentados por medio de videos de caso y repertorio de experiencias profesionales y pedagógicas (PaP-eRs). Esta heurística redujo la complejidad de la enseñanza en una historia manejable situada en un contexto específico, para que los profesores pudieran identificar y reflexionar sobre sus teorías acerca de la enseñanza y aprendizaje de la química. El estudio evidenció que los profesores en formación identificaron y desarrollaron los siguientes elementos del CTPC de la química: la pedagogía general, el lenguaje como una herramienta de aprendizaje, las dificultades y concepciones alternativas, el conocimiento de la tecnología como un instrumento para representar los contenidos y gestionar el aula de química, y la evaluación formativa. Definitivamente, la reflexión de los eventos críticos de los PaP-eRs y videos de caso fue considerada una heurística apropiada que les permitió a los futuros profesores articular el conocimiento proveniente de la literatura en educación en química, con las experiencias virtuales de enseñanza/aprendizaje procedentes de un contexto real. Desde luego, dicha reflexión estuvo mediada por la lectura y discusión de las acciones inteligentes de un docente ejemplar cuando orienta a unos estudiantes singulares desde una perspectiva sociocultural, con el propósito de comenzar a refinar sus teorías de la enseñanza y aprendizaje de la química.
Effects of Whole-Body Vibration Versus Pilates Exercise on Bone Mineral Density in Postmenopausal Women: A Randomized and Controlled Clinical Trial
Authors: de Oliveira Laís Campos , de Oliveira Raphael Gonçalves , de Almeida Pires-Oliveira Deise Aparecida 
Published: February 2018

Background and Purpose:
Decreased bone mineral density (BMD) is a common condition in postmenopausal women that can be managed with impact activities. Among the activities studied are the whole-body vibration (WBV) and muscle-strengthening exercises. The purpose of this study was to compare the effects of WBV versus Pilates exercise on BMD in postmenopausal women.

Methods:
In this study, 51 postmenopausal women were randomized into 3 groups: vibration (n = 17), Pilates (n = 17), and control (n = 17). Outcomes were the areal bone mineral density (aBMD) (lumbar spine, femoral neck, total hip, trochanter, intertrochanter, and ward's area) assessed by dual-energy x-ray absorptiometry at baseline and follow-up. The interventions were performed 3 times a week for 6 months, totaling 78 sessions. The analysis was performed with intention-to-treat and covariance analyses adjusted for baseline outcomes.

Results:
After 6 months, 96.1% of the participants completed the follow-up. The analyses demonstrated significant mean between-group differences in favor of the interventions: vibration versus control, for the aBMD of the lumbar spine (0.014 g/cm2; 95% confidence interval [CI], 0.006-0.022; P = .018, d = 1.21) and trochanter (0.018 g/cm2; 95% CI, 0.006-0.030; P = .012, d = 1.03); and Pilates versus control, for the aBMD of the lumbar spine (0.016 g/cm2; 95% CI, 0.007-0.025; P = .008, d = 1.15) and trochanter (0.020 g/cm2; 95% CI, 0.010-0.031; P = .005, d = 1.28).

Conclusion:
In postmenopausal women, 3 weekly sessions of WBV or Pilates administered for 6 months provided an equal effect on BMD.
Families’ Experiences With Pediatric Family-Centered Rounds: A Systematic Review
Authors: Rea Kelly E. , Rao Priyanka , Hill Elizabeth , Saylor Kate M. , Cousino Melissa K. 
Published: February 2018

CONTEXT:
Family-centered rounding (FCR) is of increasing importance in pediatric medicine. Although researchers have begun to understand the effect of FCR on providers and systematic health care outcomes, we provide a systematic review of the literature regarding families’ experiences with FCR.

OBJECTIVE:
To systematically review patient and family experiences with pediatric FCR.

DATA SOURCES:
Our data sources included PubMed, Cumulative Index to Nursing and Allied Health Literature, PsycINFO, Scopus, and Embase.

STUDY SELECTION:
Inclusion criteria included publication in a peer-reviewed journal between January 2007 and February 2017, written in the English language, pediatric population (patients 0–21 years), and specific measurement of a families' experience with FCR.

DATA EXRACTION
Data extracted were sample size, participating medical unit, measures of family experience, and overall results of family experience.

RESULTS:
Twenty-eight studies were included. It is unclear whether participation in FCR increases family satisfaction compared with standard rounds; however, families report a strong desire to participate in FCR. Family benefits of FCR included increased understanding of information and confidence in the medical team, as well as reduced parental anxiety.

LIMITATIONS:
There were only 2 studies in which researchers examined pediatric patients’ experiences with FCR, and literature on the communication needs of non–English-speaking families was also limited.

CONCLUSIONS:
Overall, it is suggested that families positively perceive their experience with FCR, although more research is needed to determine if satisfaction is greater in FCR versus standard rounds as well as to better understand different perspectives of adolescent patients and non–English-speaking families.
FDA Approval Summary: Dabrafenib and Trametinib for the Treatment of Metastatic Non-Small Cell Lung Cancers Harboring BRAF V600E Mutations
Authors: Odogwu Lauretta , Mathieu Luckson , Blumenthal Gideon , Larkins Erin , Goldberg Kirsten B. , Griffin Norma , Bijwaard Karen , Lee Eunice Y. , Philip Reena , Jiang Xiaoping , Rodriguez Lisa , McKee Amy E. , Keegan Patricia , Pazdur Richard 
Published: February 2018

Abstract

On June 22, 2017, the Food and Drug Administration expanded indications for dabrafenib and trametinib to include treatment of patients with metastatic non-small cell lung cancer (NSCLC) harboring BRAF V600E mutations. Approval was based on results from an international, multicenter, multicohort, noncomparative, open-label trial, study BRF113928, which sequentially enrolled 93 patients who had received previous systemic treatment for advanced NSCLC (Cohort B, n = 57) or were treatment-naïve (Cohort C, n = 36). All patients received dabrafenib 150 mg orally twice daily and trametinib 2 mg orally once daily. In Cohort B, overall response rate (ORR) was 63% (95% confidence interval [CI] 49%–76%) with response durations ≥6 months in 64% of responders. In Cohort C, ORR was 61% (95% CI 44%–77%) with response durations ≥6 months in 59% of responders. Results were evaluated in the context of the Intergroupe Francophone de Cancérologie Thoracique registry and a chart review of U.S. electronic health records at two academic sites, characterizing treatment outcomes data for patients with metastatic NSCLC with or without BRAF V600E mutations. The treatment effect of dabrafenib 150 mg twice daily was evaluated in 78 patients with previously treated BRAF mutant NSCLC, yielding an ORR of 27% (95% CI 18%–38%), establishing that dabrafenib alone is active, but that the addition of trametinib is necessary to achieve an ORR of &gt;40%. The most common adverse reactions (≥20%) were pyrexia, fatigue, nausea, vomiting, diarrhea, dry skin, decreased appetite, edema, rash, chills, hemorrhage, cough, and dyspnea.

Implications for Practice
The approvals of dabrafenib and trametinib, administered concurrently, provide a new regimen for the treatment of a rare subset of non-small cell lung cancer (NSCLC) and demonstrate how drugs active for treatment of BRAF-mutant tumors in one setting predict efficacy and can provide supportive evidence for approval in another setting. The FDA also approved the first next-generation sequencing oncology panel test for simultaneous assessment of multiple actionable mutations, which will facilitate selection of optimal, personalized therapy. The test was shown to accurately and reliably select patients with NSCLC with the BRAF V600E mutation for whom treatment with dabrafenib and trametinib is the optimal treatment.
Tarımsal ürün bilgilerinin bir gezgin robot yardımıyla temin edilen görüntülerin işlenmesi yoluyla analiz edilmesi
Authors: TURAN Sedat , AYDIN Tolga 
Published: February 2018

Robotik sistemlerin bir çeşidi olan gezgin (mobil)
robotların kullanımı, günlük yaşamımızın farklı alanlarında gelişerek arttığı
görülmektedir. Bu çalışmada, görüntü işleme yöntemi ile tarımsal ürün
bilgilerinin analiz edilmesi için gezgin robotik sistemin kullanılması ve
sistem kurulması aşamasında ortaya çıkabilecek problemlerin çözüm yollarının
belirlenmesi amaçlanmıştır. Kablosuz veri iletimi kullanılarak gezgin robot
üzerinden gönderilen görüntü, ortam
sıcaklığı ve nem verileri kullanıcı tarafına aktarılmıştır. Böylece, kullanıcı
tarafında görüntü işleme yöntemlerinden faydalanılarak geliştirilen yazılım
sayesinde görüntü verilerinden bazı bilgiler elde edilmektedir. Görüntü işleme
tekniklerinin kullanıldığı yüz tanıma ve ürün bilgisi analiz denemelerinde
gezgin robot üzerindeki kameranın kalitesi, ortam aydınlatması, gölgelenme,
ürünlerin fiziksel yapıları ve yüz eğitim sayısı robotik sisteme doğrudan
etkisi olduğu anlaşılmıştır. Araştırma sonucunda robotik sistemin arazide rahat
hareket edebilmesi için hareket sisteminde kullanılan mekanik yapının sanayi
tipinde olması gerektiği görülmüştür.
Clinical profile and outcome of early onset sepsis in high risk very low birth weight neonates
Authors: Shukla Omprakash S. , Rawat Aditi 
Published: February 2018

Background: Neonatal sepsis is one of the main causes of mortality and morbidity, especially in very low birth weight neonates (birth weight <1499 grams) despite the progress in hygiene, introduction of new and potent antimicrobial agents for treatment and advanced measures for diagnosis. The aim of the study was to find correlation of clinical features and risk factors of neonatal sepsis in culture positive cases.Methods: A cross- sectional study was carried out in one hundred neonates with risk factors of septicemia after obtaining informed consent. Blood culture was done using Bactec Peds Plus/F Culture as a gold standard to diagnose septicaemia. Correlation of risk factors, clinical features with laboratory findings was obtained by using chi-square test. p-value of less than 0.05 was considered as significant.Results: Out of 100 neonates with suspected sepsis, BACTEC culture proven sepsis was seen in 40% cases. Gram negative sepsis was seen in 62.5% cases. The most common bacteria for early onset sepsis were Klebsiella, Pseudomonas and MRSA contributing 17% each to the bacteriological profile. The most common predisposing factor and clinical feature in culture positive cases were Premature rupture of membrane >24 hours (67%) and bleeding/petechia/pupura (72%) respectively. The major cause of mortality was pulmonary hemorrhage.Conclusions: Gram negative organism were more common and associated with higher mortality. Blood culture positivity increases with increase in number of risk factors in neonatal septicemia. A detailed history and thorough clinical examination is vital for early recognition of sepsis.
Does Changing Newborn Bath Procedure Alter Newborn Temperatures and Exclusive Breastfeeding?
Authors: Suchy Carol , Morton Cyndi , Roy Ramos Rocky , Ehrgott Alexandra , Quental Megan Marie , Burridge Amanda , Rutledge Dana N. 
Published: February 2018

This evidence-based practice project evaluated effects of changing timing/character of initial newborn baths on infant temperatures and breastfeeding status.The hospital protocol for initial bathing procedures was updated: immersion baths; 12 hours postpartum; family included.Staff nurse champions provided staff training. The evaluation included three seven-week periods (2016–2017) and three measures: adherence, temperature stabilization, and exclusive breastfeeding.Of 1,205 38-week healthy newborns, 322 were born preimplementation (Pre), 486 after (Post), and 397 during maintenance (M). Adherence to bath timing increased and was maintained: 28 percent Pre; 83 percent Post; 85 percent M. Almost 100 percent of newborns had stable temperatures. Breastfeeding exclusivity rates did not change (ps greater than or equal to .05): baths less than 12 hours: 79 percent Pre, 74 percent Post, and 68 percent M; baths 12 hours: 68 percent Pre, 71 percent Post, and 73 percent M.Changing bath time/character for healthy newborns maintained thermoregulation and exclusive breastfeeding rates. Nurses changed practice quickly, maintaining adherence over time.
Entropi Kavramıyla Geçmişten Günümüze Helvetica'ya Bir Bakış ve Deneysel Tipografi
Authors: Akman Mustafa 
Published: February 2018

Günümüzde popülerleşen entropi kavramının tanımlaması yapılıp temel ilkelerine değinerek tipografiyle olan ilişkisi göz önüne alınmıştır. Entropi kavramının diğer alanlarla birlikte incelenmesi, entropi ile diğer kavramlar arasında yeni bağların kurulmasını sağlamaktadır. Entropi kavramı
çerçevesinde Helvetica’nın tarihine bakarak, Helvetica yazı yüzünün değeri, anlamı, sorunları ve
konumu üzerine bir inceleme yapılmıştır. Kısaca Helvetica’nın entropisi hakkında bilgi verilmiş ve
daha sonra deneysel tipografi çalışmalarıyla örneklendirilip görselleştirilmiştir. Yapılan inceleme
ve deneysel tipografi çalışmaları sonucunda bazı durumlar tespit edilmiş ve sonuç bölümünde
paylaşılmıştır.&nbsp;
Yemek Kültürü ve Sofra Seramikleriyle Etkileşimi
Authors: Sevim Cemalettin 
Published: February 2018

İnsanın hayatı boyunca vazgeçemediği yaşamsal ihtiyaçlarından bir tanesi yemek yemedir. Yemekler ve kullanılan kaplar kültür ve geleneklere dayalı olarak tercihlere göre değişkenlik gösterir.

İnsan, yemek ve yemek kabının ayrılmaz birlikteliği insanlık var olduğu sürece devam edecektir.
Bu birliktelik sürecinde yemekler, yemek kapları, yemek kaplarının malzemeleri ve biçimleri teknolojik gelişmelerin paralelinde kültür, fonksiyonellik ve kişisel beğeniler doğrultusunda gelişmeler
göstermiştir. Tarihsel süreçte cam, metal, taş, plastik, ahşap gibi birçok farklı malzeme ile yapılan
yemek kapları karşımıza çıkmaktadır. Ancak yemek kabı olarak kullanılan en eski malzemelerden
bir tanesi de seramiktir.

Bu makalede yemek kültürünün artistik ve fonksiyonel sofra seramikleri ile etkileşimi incelenerek bu birlikteliğin günümüzdeki son durumu ve kullanıcıların beklentileri değerlendirilecektir.&nbsp;