bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Interplay between the Otsus Fund, Capital Expenditure, and Regional Economic Performance in Aceh Province
Authors: Herdiyana Deni , Qadri Resi Ariyasa , Sutarto Sutarto , Kustiani Nur Aisyah , Andriana Nina 
Published: November 2024

This study aims to examine the impact of the Special Autonomy Fund on economic growth as measured by GRDP in the province of Nanggroe Aceh Darussalam (NAD). The research was conducted using the quantitative method of two-stage linear regression analysis. The independent variables used in this research model are General Allocation Funds (DAU), Revenue Sharing Funds (DBH), Special Allocation Funds (DAK), Special Autonomy Funds (Otsus Fund), and Regional Revenue (PAD) while the dependent variable is GRDP. Capital Expenditure is selected as an intervenning variable. The data used in this study is panel data from 23 regencies/cities in NAD Province for 5 years from 2015-2020.
The recommendation from the research results is that the Otsus Fund should still be continued and extended where the Otsus Fund will end in 2028, because the results of the research found an indirect positive effect of the Otsus Fund on GRDP through Capital Expenditures at Lag-1. In the first stage of regression, it was found that DAK and Dana Otsus had a positive effect on Capital Expenditures, while DAU and DBH had no significant effect. In the second stage of regression, it was found that Capital Expenditures had a significant effect on GRDP.

Keywords: General Allocation Funds, Revenue Sharing Funds, Special Allocation Funds, Special Autonomy Fund, Capital Expenditure, Economic Growth
ANALISIS KELAYAKAN USAHA SAYURAN HIDROPONIK PADA KELOMPOK WANITA TANI DI KOTA PANGKALPINANG
Authors: Aulia Dinda , Karsiningsih Eni , Purwasih Rati 
Published: November 2024

Usaha sayuran hidroponik yang digeluti 13 Kelompok Wanita Tani (KWT) di Kota Pangkalpinang merupakan usaha yang tergolong baru sehingga penjualan masih tergolong rendah. Usaha sayuran hidroponik sudah bersifat komersial tetapi cakupan penjualan belum konsisten sehingga masih kecilnya jumlah pendapatan yang diterima tetapi modal usahatani tetap dikeluarkan. Penelitian ini bertujuan untuk 1). menganalisis kelayakan non finansial usaha sayuran hidroponik, 2). menganalisis kelayakan finansial usaha sayuran hidroponik, dan 3). menganalisis sensitivitas usaha sayuran hidroponik pada Kelompok Wanita Tani (KWT) di Kota Pangkalpinang. Metode penelitian yang digunakan adalah studi kasus dengan mengambil kasus usaha sayuran hidroponik pada Kelompok Wanita Tani (KWT) di Kota Pangkalpinang. Analisis data yang digunakan adalah kualitatif dan kuantitatif. Data kualitatif disajikan dalam bentuk deskriptif untuk menjelaskan aspek non finansial usaha sayuran hidroponik, yaitu aspek pasar dan pemasaran, aspek teknis, aspek hukum dan perizinan, aspek ekonomi, serta aspek lingkungan. Pada analisis kualitatif digunakan untuk menyelesaikan perhitungan analisis kelayakan finansial berupa nilai NPV, IRR, Net B/C, dan Payback Period. Hasil penelitian menyatakan bahwa berdasarkan aspek non finansial usaha sayuran hidroponik sudah dikatakan layak untuk tetap dijalankan. Berdasarkan aspek finansial usaha sayuran hidroponik sudah dikatakan layak untuk tetap dijalankan karena memiliki nilai NPV sebesar Rp 3.832.119, IRR sebesar 16%, Net B/C Ratio sebesar 1,29 dan Payback Period selama 1 tahun 5 bulan. Analisis sensitivitas menunjukkan usaha sayuran hidroponik mencapai kondisi tidak layak untuk diusahakan dengan nilai NPV sebesar –Rp 901.033, IRR sebesar 12% dan Net B/C Ratio sebesar 0,92.
Russian language in the space of the Russian World: from status determination to the postulation of care
Authors: Babaeva Anastasiya Valentinovna 
Published: November 2024

The focus of this article is on the problem of determining the status and role of the Russian language in the space of the Russian world. The author attempts to revise the fundamental approaches: ideological, cultural and linguistic-semiotic, which have been identified in domestic research on this issue over the past decades, and assess the relevance of the approaches today. The solution of this task requires, first of all, an analysis of the content of the concept of the "Russian World" in terms of its basic principles in order to fix the fundamental factors determining the identity of the cultural and civilizational community called the Russian World. Such an analysis in itself constitutes a problem area, since science has not developed a unified and clear approach to interpreting the content of the concept. This entails a whole range of problems. The research methodology is based on theoretical analysis and synthesis, as well as generalization of analytical sources. The theoretical framework of the work is based on the thesis that Russia is the core of a special civilizational community. Russian language is a leading factor of identification in the process of development of the Russian world, from the moment of the origin of the phenomenon to the present, the author argues that the importance of the Russian language as a leading factor of identification in the process of development of the Russian world is gradually decreasing. The reasons for this kind of change should be sought not only in the fields of politics and economics, but also in the field of culture, both in the external circuit and in the internal one. The author believes that the process of transformation of the functional of the Russian language and the decrease in the importance of its role in identification processes has not only objective and legitimate reasons. Negative factors adversely affect the Russian language and create certain threats. In support of this position, theoretical arguments based on historical sources, the work of modern authors and the results of empirical research are presented.
Transglutaminase 2 inhibition ameliorates cardiac fibrosis in myocardial infarction by inducing M2 macrophage polarization in vitro and in vivo
Authors: Maimaitijiang Alimujiang , Huang Qingyu , Wu Yurong , Sun Shengjia , Chen Qiying 
Published: November 2024

Objective:
Macrophages perform vital functions in cardiac remodeling after myocardial infarction (MI). Transglutaminase 2 (TG2) participates in fibrosis. Nevertheless, the role of TG2 in MI and mechanisms underlying macrophage polarization are unclear. This study aimed to discover the functions and possible mechanisms of TG2 in MI.

Material and Methods:
C57BL/6 mice were classified into three groups (six mice per group): Sham, MI, and MI+GK921 groups. GK921 acts as a TG2 inhibitor. Cardiac function, myocardial cell apoptosis, fibrosis, and macrophage phenotype in mouse experiments were detected through echocardiography, terminal deoxynucleotidyl transferase dUTP nick end labeling, Masson staining, immunofluorescence, and flow cytometry, respectively. The in vitro study involved the treatment of mouse cardiac fibroblasts isolated from mice with transforming growth factor β1 (TGF-β1) and evaluation of fibrosis through the detection of the expressions of fibrosis-associated proteins using Western blot. Bone marrow-derived macrophages (BMDMs) obtained from mice were triggered by interleukin (IL)-4, and the type of macrophages was determined through flow cytometry.

Results:
In in vivo experiments, GK921 substantially improved cardiac injury and fibrosis, induced M2 macrophage polarization, and suppressed the TGF-β1/small mother against decapentaplegic 3 (Smad3) pathway in MI mice. Moreover, TG2 knockdown considerably decreased the expressions of fibrosis-associated proteins in TGF-β1-triggered mouse cardiac fibroblasts, which indicates the repressive effect of TG2 knockdown on fibrosis. In addition, the inhibition effect of TG2 downregulation on the TGF-β1/Smad3 pathway was proven in TGF-β1-treated mouse cardiac fibroblasts in vitro. Moreover, TG2 inhibition remarkably increased M2 macrophage polarization in IL-4-induced BMDMs.

Conclusion:
TG2 inhibition facilitated M2 macrophage polarization to provide protection against MI-caused cardiac fibrosis in mice, and these effects may be attained through modulation of the TGF-β1/Smad3 pathway.
Fertility Problems Due to Chrono-Disruption: A Mini Review
Authors: Das Megha , Yadav Sanjeev Kumar , Mishra Nitesh Kumar , Haldar Chandana 
Published: November 2024

Circadian rhythm coordinates many physiological and behavioural processes and is under the control of the endogenous suprachiasmatic nucleus (SCN) entrained by a light-dark cycle. The core clock genes, Bmal1, Clock, Per, and Cry, organised are organised in a transcriptional–translational feedback loop (TTFL) of the 24-h cycle. Recently, these clocks have been reported in the female reproductive organs, i.e., ovary, uterus, etc. The presence of clock genes in female reproductive tissues has generated the interest of reproductive biologists towards chrono-regulation, as the clock genes may play a central role in coordinating the circadian rhythm of the reproductive process, i.e., form ovulation, fertilisation and implantation to lactation. Studies have demonstrated a critical connection between disturbance of the master circadian clock (SCN) of the hypothalamus and infertility.
Artificial lighting is a worldwide increasing problem in the physiology of many vertebrates controlled by circadian/seasonal entrainments. The effect of artificial light on circadian dysregulation in the night-shift working females resulted in severe reproductive dysfunction (low pregnancy outcomes, childbirth weight, multiple miscarriages, etc.). Inappropriate exposure to artificial light/chrono disruption can lead to several disturbances to the biological/physiological rhythms of metabolomics and hormones.
In the present mini review, we proposed that the duration of light affects the circadian coordination of central (SCN) and peripheral clock (ovarian and uterine clock) oscillations regulating uterine tissue homeostasis and pregnancy success in golden hamsters. Two major aspects of light exposure, i.e., (1) continuous and (2) long-time artificial light at night (ALAN), influence circadian oscillations of clock genes on SCN, ovary, and uterus as well as the molecular mechanism behind the altered clock entrainments that finally induce the female reproductive impairments via alteration in hypothalamic-pituitary-gonadal (HPG) axis.Keywords: Smoking, Semen Quality, Sperm Parameters, Male Infertility, North India, Fertility Treatment, Smoking Cessation.
Efficacy of leprosy vaccines across the globe: A systematic review & meta-analysis of randomized controlled trials
Authors: Dasgupta Shreyashi , Mukherjee Shatavisa , Bagchi Chiranjib , Das Saibal , Saha Indranil , Kalita Manoj , Bagepally Bhavani Shankara , Guha Subhasish Kamal 
Published: November 2024

Background & objectives
Although multi-drug therapy has decreased the burden of disease, leprosy is yet to be eliminated. Accelerating progress requires optimal use of existing tools, advanced diagnostic tests, newer drugs, and vaccines. The search for a vaccine with therapeutic and preventive potential is ongoing, but evidence on effectiveness and safety is lacking. This systematic review and meta-analysis will evaluate and compare the clinical efficacy, immunogenicity, and safety of leprosy vaccines in humans.

Methods
In June 2024, three databases were systematically searched with updated search keywords. Randomized controlled trials (RCTs) pertaining to leprosy vaccines for humans which evaluated either therapeutic or prophylactic vaccines in leprosy with a placebo or active comparator arm, with full-text access, were included in the study. There were no restrictions on language, country or date. For the risk of bias assessment in the studies included, the revised Cochrane risk-of-bias 2 tool for RCTs was used. A P value (two-sided) of <0.05 was considered as significant for all tests; however for heterogeneity, a one-sided P value of <0.1 was considered as statistically significant. The quality of generated evidence specific to the desired outcomes were assessed using the GRADE approach (Grading of Recommendations Assessment, Development and Evaluation). The study protocol was registered in PROSPERO (ID: CRD42024561651).

Results
A total of 2163 studies were retrieved from different databases. After removing duplicates and full text screening, 12 articles were finally selected. Out of these studies, eight used leprosy vaccines on prophylactic basis, while four used leprosy vaccines on therapeutic basis. In therapeutic use of leprosy vaccine, Ramu’s score was found to be significantly protective [-3.06 (95% confidence interval (CI): -3.96 to -2.16)] among the recipients of the therapeutic leprosy vaccine. Bacterial index was found to be insignificant [-0.26 (95% CI: -1.54 to 1.03)] among the recipients of therapeutic leprosy vaccine. In subgroup analysis among the eight prophylactic vaccine studies, pooled relative risk was found to be 0.61 (95% CI: 0.41 – 0.91).

Interpretation & conclusions
The findings of this meta-analysis suggest that both prophylactic and therapeutic leprosy vaccines were significantly better compared to the placebo. Leprosy vaccine in the form of Mw/Mycobacterium welchii/MIP along with combination of World Health Organization (WHO) multi-drug therapy (MDT) or Bacillus Calmette-Guerin (BCG) vaccine along with second line treatment with rifampicin were found to be protective among the recipients.
National and international comparison of Turkish health system outcome indicators and policy recommendations
Authors: Topaktaş Gülsen , Beylik Umut 
Published: November 2024

Objectives:
The study aims to analyze and make recommendations based on comparison of the results of the Turkish Health System both national and internationally.

Materials and Methods:
In the study, comments were made within the scope of trend analysis and comparison methods and discussed with the literature. The study data belonged to 2022 and were obtained from the Health Statistics Yearbook of the Ministry of Health, TURKSTAT, Organisation for Economic Co-operation and Development Health Data and EUROSTAT database. Average life expectancy, infant mortality rate, maternal mortality rate, satisfaction ratio with health-care services, and health expenditure impact data were taken into consideration.

Results:
There was poor performance internationally in terms of infant mortality rate and maternal mortality rate. There are extreme differences in these indicators between regions of Turkey. The level of patient satisfaction is well-positioned internationally. However, looking at its trend, it has entered a period of stagnation and decline. The increase in health expenditures in Turkey has also resulted in an increase in average life expectancy and patient satisfaction.

Conclusion:
It has been observed that Turkish’s health system is in the process of transition from middle-upper income group countries to upper-income group countries in terms of its results and performance, but the imbalances in access to service and health service quality between regions and the stagnating system produce negative results and cannot renew itself.
Prevalence and Pattern of Upper Gastrointestinal Lesions in Prospective Kidney Transplant Patients in Bangladesh
Authors: Islam Sumona , Kabir Md Anwarul , Bari Amit , Ghosh Chanchal Kumar , Alam Md Razibul , Khan Nabila Tasneem , Tabassum Nowrin , Rakhi Farjana Sultana , Dey Suman , Danish Mohammed Reazuddin 
Published: November 2024

Background
Upper gastrointestinal (GI) lesions are common in patients with chronic kidney disease and may contribute to anemia and increased morbidity, especially in patients on hemodialysis (HD). They become even more significant in patients undergoing kidney transplantation about to be subjected to lifelong immunosuppressive drugs.

Materials and Methods
This cross-sectional study conducted at Bangabandhu Sheikh Mujib Medical University’s Departments of Gastroenterology and Nephrology analyzed 128 prospective kidney transplant patients following upper GI endoscopy. Lesions were histopathologically examined and factors contributing to and consequences of the lesions were investigated.

Results
A total of 52.3% patients had at least one upper GI lesion. Gastritis was the most prevalent one, comprising 55.7% of the lesions, followed by duodenitis (21.6%), ulcer (12.5%), esophagitis (2.3%), and others (8%). Lesions did not vary significantly between symptomatic and asymptomatic patients (p = 0.9). Those on HD had 3.6-fold higher odds of having a lesion (p = 0.005). Patients with lesions had significantly longer CKD duration (p = 0.0002). Mean hemoglobin level was 8.8 g/dl in those with lesions, which was significantly lower compared to those without lesion, who had a mean of 10.3 g/dl (p < 0.0001). Iron deficiency was more common in patients with lesions (p = 0.0004). The mean serum calcium level was significantly higher in patients with lesions (p = 0.0002).

Conclusion
Upper GI lesions are fairly common in Bangladeshi CKD population. Routine endoscopic screening and treatment of asymptomatic lesions are recommended for advanced CKD patients in Bangladesh, given their frequency and potential impact.
ВЛИЯНИЕ ВНЕШНЕЙ СРЕДЫ НА ПРОТИВОДЕЙСТВИЕ ЭКСТРЕМИЗМУ И ТЕРРОРИЗМУ ОПЕРАТИВНО-РОЗЫСКНЫМИ ОРГАНАМИ
Authors: А.Г. Ахмедов , Т.О. Бозиев 
Published: November 2024

Статья посвящена исследованиям влияния различных факторов на оперативную обстановку в целом и внешних факторов в частности на деятельность оперативно-розыскных органов (далее – ОРО), осуществляющих противодействие экстремизму и терроризму. Предпринята попытка систематизации и анализа складывающейся оперативной обстановки в аспекте противодействия рассматриваемым опасным преступлениям в целом и факторов внешней среды, оказывающих влияние на эффективное противодействие ОРО экстремизму и терроризму, в частности.
We consider the influence of various factors on the operational environment as a whole and external factors in particular on the activity of operational search bodies counteracting extremism and terrorism. We make an attempt to systemize and analyze current operational environment from the point of view of counteracting violent crimes on the whole and external environment factors affecting effective counteraction of operational search bodies to extremism and terrorism in particular.
РАЗВИТИЕ ТЕХНОЛОГИЙ ПРЕДОСТАВЛЕНИЯ УСЛУГ В СОЦИАЛЬНОЙ СФЕРЕ В УСЛОВИЯХ НЕОБХОДИМОСТИ ЭКОНОМИИ БЮДЖЕТНЫХ РАСХОДОВ
Authors: Н.В. Сипунова 
Published: November 2024

Статья посвящена исследованию способов оптимизации бюджетных расходов путем снижения издержек при предоставлении социальных услуг. Определены наиболее перспективные технологии предоставления услуг в социальной сфере в условиях необходимости экономии расходов и снижения издержек. Комплексное внедрение технологий цифровизации, а также технологий «одного окна» и технологии социального картирования, в том числе в цифровой форме, позволит повысить эффективность предоставления услуг и будет способствовать более рациональному расходованию бюджетных ресурсов.
The research is devoted to the ways of optimization of budgetary spending via cutting costs when rendering social services. We reveal the most promising service technologies in social sphere under budget savings and cost-cutting. A complex implementation of digital technologies as well as single window system and social cards, including digital ones, will increase service effectiveness and contribute to a more rational budget spending.
ТЕНДЕНЦИИ И ПЕРСПЕКТИВЫ РАЗВИТИЯ ПРЕДПРИНИМАТЕЛЬСТВА В СФЕРЕ УСЛУГ ПО ОРГАНИЗАЦИИ ДЕТСКОГО ОТДЫХА В РОССИИ
Authors: А.В. Карасёв , А.Е. Трубин 
Published: November 2024

В научной статье представлены результаты анализа основных тенденций и перспективы развития предпринимательской деятельности в сфере оказания услуг по организации детского отдыха в России. Рассмотрено, какое значение имеют услуги в сфере детского отдыха. Актуальность исследования на выбранную тематику обусловлена тем, что сфера услуг детского отдыха в современной России еще не составляет значительную долю в сегменте услуг, однако с каждым годом увеличивается потребность в оказании подобных услуг. Вслед за спросом и интересом родителей появляется и предложение, что отражается в открытии новых субъектов предпринимательства. Объектом научной работы являются предприятия сферы услуг детского отдыха. Предметом исследования выступают тенденции и перспективы развития предпринимательства в сфере услуг детского отдыха российской экономики. Результаты научной работы позволяют выявить актуальные проблемы, которые создают барьеры для открытия и стратегического развития предпринимательства в сфере услуг детского отдыха России. Определены методы и инструменты, позволяющие стимулировать развитие предпринимательства в сфере услуг детского отдыха российской экономики. Благодаря их реализации улучшится конкурентная политика в сфере услуг детского отдыха, что положительно повлияет на качество и доступ для родителей.
We present the results of the analysis of the main trends and prospects of the development of entrepreneurial activity concerning children recreation in Russia. We consider the role of the services in the sphere in question. Currently, the share of travel services for children is not big, but the need for them is increasing steadily, which determines the relevance of the research. The supply follows the demand and the parents’ interest, which is reflected in the emergence of new businesses. The research is focused on the businesses connected with the recreation for children. Trends and prospects of business development in the sphere represent the subject of the study. The research results contribute to revealing the problems that inhibit the emergence and strategic development of entrepreneurship concerning children recreation in Russia. We determine methods and tools to boost the development of entrepreneurship in the service sector of children recreation. Their application is to improve the competition policy in the sector, which will have a positive impact on the quality and accessibility of the services for parents.
ВЛИЯНИЕ ЭКОСИСТЕМ НА ЦИФРОВУЮ ТРАНСФОРМАЦИЮ ЭКОНОМИКИ
Authors: В.В. Макаров , Е.В. Павлова 
Published: November 2024

Четвертая промышленная революция обусловила кардинальные изменения в процессах производства, распределения и обмена товарами и услугами в связи с повсеместным внедрением цифровых технологий во все стадии создания и потребления экономических благ. Развитие информационных технологий и, в частности, распространение цифровых платформ обусловило появление новой модели ведения бизнеса – цифровых экосистем. В статье исследуются положительные аспекты влияния экосистем на цифровизацию экономики и возможные негативные последствия их развития и распространения на экономику и общество в целом.
Industry 4.0 has stipulated dramatic changes in manufacturing, distribution and exchange of goods and services due to the widespread introduction of digital technologies into all stages of creating and consuming economic goods. The development of information technology and, in particular, the spread of digital platforms has led to the emergence of a new business model - digital ecosystems. We look at positive aspects of the ecosystems influence on the digitalization of the economy and possible negative consequences of their development and spreading in the economy and society as a whole.