bluuebunny/crossref_metadata_2025_split huggingface dataset:
Whey protein isolate supplementation improves body composition, muscle strength, and treatment tolerance in malnourished advanced cancer patients undergoing chemotherapy
Authors: Cereda Emanuele , Turri Annalisa , Klersy Catherine , Cappello Silvia , Ferrari Alessandra , Filippi Andrea Riccardo , Brugnatelli Silvia , Caraccia Marilisa , Chiellino Silvia , Borioli Valeria , Monaco Teresa , Stella Giulia Maria , Arcaini Luca , Benazzo Marco , Grugnetti Giuseppina , Pedrazzoli Paolo , Caccialanza Riccardo 
Published: October 2019

AbstractIn recent years, whey proteins (WP) have attracted increasing attention in health and disease for their bioactive functions. The aim of this study was to evaluate the benefit of WP isolate (WPI) supplementation in addition to nutritional counseling in malnourished advanced cancer patients undergoing chemotherapy (CT). In a single‐center, randomized, pragmatic, and parallel‐group controlled trial (ClinicalTrials.gov: NCT02065726), 166 malnourished advanced cancer patients with mixed tumor entities candidate to or undergoing CT were randomly assigned to receive nutritional counseling with (N = 82) or without (N = 84) WPI supplementation (20 g/d) for 3 months. The primary endpoint was the change in phase angle (PhA). Secondary endpoints included changes in standardized PhA (SPA), fat‐free mass index (FFMI), body weight, muscle strength, and CT toxicity (CTCAE 4.0 events). In patients with the primary endpoint assessed (modified intention‐to‐treat population), counseling plus WPI (N = 66) resulted in improved PhA compared to nutritional counseling alone (N = 69): mean difference, 0.48° (95% CI, 0.05 to 0.90) (P = .027). WPI supplementation also resulted in improved SPA (P = .021), FFMI (P = .041), body weight (P = .023), muscle strength (P < .001), and in a reduced risk of CT toxicity (risk difference, −9.8% [95% CI, −16.9 to −2.6]; P = .009), particularly of severe (grade ≥ 3) events (risk difference, −30.4% [95% CI, −44.4 to −16.5]; P = .001). In malnourished advanced cancer patients undergoing CT, receiving nutritional counseling, a 3‐month supplementation with WPI resulted in improved body composition, muscle strength, body weight, and reduced CT toxicity. Further trials, aimed at verifying the efficacy of this nutritional intervention on mid‐ and long‐term primary clinical endpoints in newly diagnosed specific cancer types, are warranted.
The implication of lncRNA expression pattern and potential function of lncRNA RP4‐576H24.2 in acute myeloid leukemia
Authors: Zheng Jifu , Song Yuan , Li Zhenjiang , Tang Aiping , Fei Yan , He Wenfeng 
Published: October 2019

AbstractBackgroundRecent studies have revealed that long noncoding RNAs (lncRNAs) may hold crucial triggers of the pathogenesis of hematological malignancies, while the studies evaluating the expression pattern of lncRNA in acute myeloid leukemia (AML) are few. Thus, this study aimed to investigate the implication of lncRNA expression pattern in AML development and progression.MethodsBone marrow samples from four AML patients and four controls were subjected to lncRNA sequencing. Then, bone marrow samples from 110 AML patients and 40 controls were proposed to real‐time quantitative polymerase chain reaction (RT‐qPCR) validation for 10 candidate lncRNAs. Clinical data and survival profiles were recorded in AML patients. Furthermore, lncRNA RP4‐576H24.2 expression in AML cell lines and its effect on AML cell proliferation and apoptosis were detected.ResultsLncRNA expression pattern by sequencing clearly distinguished AML patients from controls, and 630 upregulated and 621 downregulated lncRNAs were identified in AML patients compared to controls, which were mainly enriched in AML oncogene‐related biological process and pathways (such as neutrophil degranulation, leukocyte transendothelial migration, and hematopoietic cell lineage). RT‐qPCR validation observed that six lncRNAs correlated with AML risk, one lncRNA associated with risk stratification, and three lncRNAs correlated with survivals, among which lncRNA RP4‐576H24.2 was the only one correlated with AML susceptibility, risk stratification, and survivals. Further in vitro experiments showed that lncRNA RP4‐576H24.2 was upregulated in AML cell lines compared to normal bone marrow mononuclear cells (BMMCs), and promoted proliferation while inhibited apoptosis in HL‐60 and KG‐1 cells.ConclusionsLncRNA expression pattern is closely involved in the development and progression of AML, and several specific lncRNAs exhibit potential to be biomarkers for AML risk and prognosis. Besides, lncRNA RP4‐576H24.2 might be a potential oncogene in AML pathogenesis.
Detection of early stage ovarian cancer in a large community cohort
Authors: Suh‐Burgmann Elizabeth J. , Alavi Mubarika 
Published: October 2019

AbstractBackgroundAlthough detecting ovarian cancer at early stage is a highly meaningful clinical goal, no studies have evaluated early stage disease presentation in a large community‐based population and how it differs from that of late stage disease.MethodsElectronic medical records were evaluated for women diagnosed with ovarian or fallopian tube cancer in 2016 and 2017 to identify the first imaging study to detect disease. Women being followed prior to diagnosis for known genetic risk from BRCA or other mutation were excluded. The visit in which the imaging test was ordered and related encounters were reviewed to determine the indication for imaging. Patient characteristics, presenting symptoms and duration, and modality of first abnormal imaging were compared for early vs late stage ovarian cancer and by provider specialty.ResultsOf 540 women with ovarian cancer, 190 (35%) were diagnosed with early stage disease, of whom 141 (74%) were symptomatic, with 45% of women presenting to internists, 33% to gynecologists, and 20% to emergency medicine physicians. Pelvic ultrasonography detected only 23% of late stage cases whereas pelvic ultrasonography and abdominal pelvic computed tomography (CT) each detected 47% of early stage cases. While abdominal pain and bloating were common to both women with early and late stage cancer, women with early stage disease were younger (58 vs 64 years, P < .0001), more likely to present to gynecologists (33% vs 15%, P < .001) and complained more often of a palpable mass (17% vs 6%, P < .0001) or postmenopausal bleeding (11% vs 5%, P < .001).ConclusionsExcluding women with genetic predisposition to ovarian cancer known prior to diagnosis, approximately three out of four cases of early stage ovarian cancer are detected as the result of evaluation of symptoms and one in four cases are detected incidentally. Abdominal pelvic CT and pelvic ultrasonography each detect an equal proportion of early stage cases. In contrast to late stage presentation, women diagnosed with early stage disease present more often with complaints of a palpable mass or postmenopausal bleeding, particularly to gynecologists.
Caffeic Acid Alkyl Amide Derivatives Ameliorate Oxidative Stress and Modulate ERK1/2 and AKT Signaling Pathways in a Rat Model of Diabetic Retinopathy
Authors: Fathalipour Mohammad , Eghtedari Masoomeh , Borges Fernanda , Silva Tiago , Moosavi Fatemeh , Firuzi Omidreza , Mirkhani Hossein 
Published: October 2019

AbstractThe purpose of this study was to examine the neuroprotective effects of caffeic acid hexyl (CAF6) and dodecyl (CAF12) amide derivatives on the early stage of retinopathy in streptozotocin‐induced diabetic rats. Animals were divided in five groups (n=8/group); one group consisted of non‐diabetic rats as control, while the other four were diabetic animals either non‐treated or treated with CAF6, CAF12 or resveratrol intravitreally for four weeks. Retinal superoxide dismutase (SOD) activity and 8‐iso‐prostaglandin F2α (iPF2α) levels were evaluated by an ELISA assay. Phosphorylation of ERK1/2 and AKT was determined by immunoblotting in retinal homogenates. Retinal morphology was also examined using light microscopy. Treatment with CAF6 and CAF12 increased retinal SOD activity, while it decreased iPF2α levels in diabetic rats. Phosphorylation of ERK1/2 was increased, while AKT phosphorylation was decreased in diabetic rats compared to normal control and these alterations were significantly reversed in diabetic rats treated with CAF6 and CAF12. Furthermore, thickness of the whole retinal layer, outer nuclear layer, and ganglion cell count were decreased in diabetic rats compared to control and CAF6 and CAF12 treatments prevented these changes. CAF6 and CAF12 seem to be effective agents for treatment of diabetic retinopathy via attenuation of retinal oxidative stress and improvement of neuronal survival signaling.
A parietal bone fracture with subgaleal and subdural hemorrhage in association with vacuum extraction delivery
Authors: Marchini Giovanna , Martín Muñoz Daniel , Vladic Stjernholm Ylva 
Published: October 2019

Key Clinical MessageA neonatal parietal bone fracture was complicated by subgaleal and subdural hematomas after a vacuum extraction delivery. Low‐dose computer tomography visualized a comminuted skull fracture. Close observation of infants delivered by vacuum extraction, conservative management after a skull fracture, and further studies on vacuum traction monitoring are warranted.
Sporotrichoid‐like tuberculosis in a child: Unusual clinico‐dermoscopic aspect
Authors: Saadani Hassani Cheymae , Baybay Hanane , Ziani Jihan , Rimani Mouna , Mernissi Fatima Zahra 
Published: October 2019

AbstractTuberculosis‐ child ‐ Sporotrichoid ‐ clinical image ‐ dermoscopic image‐ correlation.
A congenital cystic pulmonary airway malformation occurring together with both an extralobar pulmonary sequestration and an esophageal duplication cyst
Authors: Dewberry Lindel C. , Trecartin Andrew , Galambos Csaba , Hilton Sarah A. , Dannull Kimberly , Zaretsky Michael V. , Behrendt Nicholas , Galan Henry L. , Marwan Ahmed I. , Liechty Kenneth W. 
Published: October 2019

AbstractA foregut duplication cyst occurring together with both a congenital cystic pulmonary airway malformation and extralobar pulmonary sequestration is an unusual combination. Prenatal ultrasound, MRI, and postnatal CT are helpful for operative planning. Surgical resection is the definitive management for all three anomalies.
Unmasking of a large pheochromocytoma by pyelonephritis
Authors: Harsch Igor Alexander , Helfritzsch Herry 
Published: October 2019

AbstractPheochromocytoma is a rare reason for hypertension. At least in younger people, an endocrinological workup of the etiology of hypertension is mandatory, as this case describes. If the pheochromocytomas are large enough, they can not only lead to hypertension but also cause direct damage to surrounding organs.
Self‐Assembly and Antitumor Activity of a Polyoxovanadate‐Based Coordination Nanocage
Authors: Zheng Yan , Gan Hongmei , Zhao Yao , Li Wanling , Wu Yuchen , Yan Xuechun , Wang Yifan , Li Jinhua , Li Juan , Wang Xinlong 
Published: October 2019

AbstractA new supramolecular nanocage, VMOP‐31, based on polyoxovanadate as the molecular building block, has been designed and synthesized under solvothermal conditions. The structure of VMOP‐31 was determined by single‐crystal and powder X‐ray diffraction, FTIR spectroscopy, UV/Vis spectrophotometry, and thermogravimetric analysis. The nanocage exhibits octahedral geometry and is constructed of six {V5O9Cl(COO)4} at the vertices and eight TATB (H3TATB=4,4′,4′′‐(s‐triazine‐2,4,6‐triyl)tribenzoic acid) ligands on the faces. Impressively, VMOP‐31 exhibited high efficiency in the inhibition of cell growth of solid tumors, such as human liver cancer cells SMMC‐7721, and superior results in the treatment of liver tumors in mice compared with classic cisplatin. Detailed studies revealed that the potential mechanism of cell death induced by VMOP‐31 involves cell cycle arrests, DNA damage, and subsequent apoptosis. Moreover, VMOP‐31 exhibited negligible side effects in the mice compared with cisplatin. To the best of our knowledge, VMOP‐31 is the first supramolecular nanocage applied to hepatic tumors both in vitro and in vivo.
The Hydrolysis of the Anhydride of 2‐Cyano‐2‐phenylpropanoic Acid Triggers the Repeated Back and Forth Motions of an Acid–Base Operated Molecular Switch
Authors: Biagini Chiara , Capocasa Giorgio , Cataldi Valerio , Del Giudice Daniele , Mandolini Luigi , Di Stefano Stefano 
Published: October 2019

AbstractThis work aimed to render phenomenologically autonomous the otherwise stepwise operation of a catenane‐based molecular switch, which is chemically triggered by the decarboxylation of 2‐cyano‐2‐phenylpropanoic acid (2). Given that any amount of 2 in stoichiometric excess with respect to the catenane is consumed in a side reaction, the authors resorted to the corresponding anhydride 5, the slow hydrolysis of which, due to adventitious water in dichloromethane, continuously produces in situ the actual fuel 2. As a consequence, the machine does not require a reloading after each cycle, but switches back and forth as long as fuel is present.
A Novel Mechanism of Preferential Enrichment Phenomenon Observed for the Cocrystal of (RS)‐2‐{4‐[(4‐Chlorophenoxy)methyl]phenoxy}propionic Acid and Isonicotinamide
Authors: Takahashi Hiroki , Numao Yuki , Motokawa Junko , Clevers Simon , Coquerel Gérard , Tsue Hirohito , Tamura Rui 
Published: October 2019

AbstractA new entry of chiral anti‐hyperlipoproteinemia drug is reported, showing an excellent preferential enrichment (PE) phenomenon which is not caused by a polymorphic transition during crystallization, but is proposed to occur by a novel mechanism involving partially irregular stacking of R and S homochiral two‐dimensional (2D) sheets with a large dipole moment, followed by selective redissolution of one homochiral 2D sheet into the mother liquor during crystallization. The cocrystal composed of (RS)‐2‐{4‐[(4‐chlorophenoxy)methyl]phenoxy}propionic acid (CPPPA) and achiral isonicotinamide exhibited a substantial enrichment in the mother liquor up to 93 % ee by simply repeating recrystallization under nonequilibrium conditions using high supersaturation. Furthermore, the deposited crystals with low ee values obtained at the end of PE experiment were second harmonic generation (SHG)‐positive, indicating the formation of homochiral domains in the deposited crystals, which reflects the proposed mechanism of PE.
Iron‐Catalyzed Cross‐Coupling of Alkynyl and Styrenyl Chlorides with Alkyl Grignard Reagents in Batch and Flow
Authors: Deng Yuchao , Wei Xiao‐Jing , Wang Xiao , Sun Yuhan , Noël Timothy 
Published: October 2019

AbstractTransition‐metal‐catalyzed cross‐coupling chemistry can be regarded as one of the most powerful protocols to construct carbon–carbon bonds. While the field is still dominated by palladium catalysis, there is an increasing interest to develop protocols that utilize cheaper and more sustainable metal sources. Herein, we report a selective, practical, and fast iron‐based cross‐coupling reaction that enables the formation of Csp−Csp3 and Csp2−Csp3 bonds. In a telescoped flow process, the reaction can be combined with the Grignard reagent synthesis. Moreover, flow allows the use of a supporting ligand to be avoided without eroding the reaction selectivity.
Tandem crystallization strategies for resolution of 3,3,3‐trifluorolactic acid [CF3CH(OH)COOH] by chiral benzylamines
Authors: Wong Lawrence W.‐Y. , Vashchenko Elena V. , Zhao Ying , Sung Herman H.‐Y. , Vashchenko Valerii V. , Mikhailenko Vadim , Krivoshey Alexander I. , Williams Ian D. 
Published: October 2019

AbstractResolution of rac‐3,3,3‐trifluorolactic acid by diastereomeric salt formation was reinvestigated. The use of (S)‐1‐phenylethylamine gives coprecipitation of two diastereomeric phases, 1 (S)‐[NH3CH(CH3)Ph](S)‐[CF3CH(OH)COO] and 2 (S)‐[NH3CH(CH3)Ph](R)‐[CF3CH(OH)COO]·H2O. Pure phase 1 may be obtained using molecular sieves as desiccants. Resolution by (S,S)‐2‐amino‐1‐phenylpropan‐1,3‐diol gives monoclinic (S,S)‐[NH3CH(CH2OH)CHOHPh] (R)‐[CF3CH(OH)‐COO] 3 with minor (S)‐3,3,3‐trifluorolactate contamination, which is precluded in the recrystallized orthorhombic form 4. A new resolution using inexpensive phenylglycinol gives pure phase 5 (S)‐[NH3CH(CH2OH)Ph] (S)‐[CF3CH(OH)COO] in 76% yield, 94% ee in a single step, in preference to its (S)‐(R) diastereomer 6. Overall efficient resolution for both enantiomers of the trifluorolactic acid (each ca. 70% yield, 99% ee) may be achieved by various two‐step “tandem” crystallizations, involving direct addition of either water or a second base to the filtrate from the initial reaction.
New AMP/polyamine blends for improved CO2 capture: Study of kinetic and equilibrium features
Authors: Patil Mayurkumar P. , Vaidya Prakash D. 
Published: October 2019

Abstract2‐Amino‐2‐methyl‐1‐propanol (AMP), which is the sterically hindered form of monoethanolamine (MEA), is a credible substitute to conventional CO2‐capturing solvents. Its performance can be improved by blending with a highly reactive polyamine promoter. Two such aqueous blends of AMP/TETA and AMP/TEPA were chosen here (TETA = triethylenetetramine and TEPA = tetraethylenepentamine). The kinetics of CO2 absorption in the proposed blends was investigated at 308, 313, and 318 K using the stirred cell technique. The concentrations of AMP and polyamine were varied between 2 to 3 kmol/m3 and 0.1 to 0.5 kmol/m3, respectively. From the measured values of the fast pseudo‐first order constants, the second‐order rate constants for the reactions of CO2 with TETA (14 695 m3/(kmol s)) and TEPA (19 250 m3/(kmol s)) were determined at T = 313 K. Both TETA and TEPA react faster with CO2 than MEA. Further, the respective activation energy values were found (40 and 37 kJ/mol). Finally, the equilibrium solubility of CO2 for both blends was measured at T = 303 K. The loading capacity was higher than that for the aqueous blends of AMP/MEA, AMP/DEA, and AMP/MDEA (here, DEA and MDEA denote diethanolamine and N‐methyldiethanolamine). The highest value of loading capacity (1.12 mol CO2/mol amine at 2.01 kPa equilibrium partial pressure of CO2) was noted in AMP/TEPA mixtures. The new findings on our proposed blends will strengthen the AMP/polyamine application in CO2 separation.
Conical filtering centrifuge for separation of solvent‐diluted bitumen from oil sand mineral particles
Authors: Khammar Merouane 
Published: October 2019

AbstractThe development of a continuous process for the separation of solvent‐diluted bitumen from mineral particles is an important step for the development of solvent‐based extraction technology of bitumen from mined oil sands. In this work, a custom‐made conical filtering centrifuge is used to separate toluene‐diluted bitumen from oil sand mineral particles. Compositions of wet granular samples are analyzed before and after centrifugation for three different oil sand ores. Results suggest that conical filtering centrifuges could be used for continuous separation of solvent‐diluted bitumen from oil sand ores with relatively coarse particles.
Quality and Possibilities of Use of Stabilized Sludge Compost Obtained by Inoculation with Geocell‐1 Consortium
Authors: Gligor Gellért , Szolnoky Tamás , Drašković Milana , Đurić Nenad , Hojka Zdravko , Bošković Jelena , Žuža Milena 
Published: October 2019

AbstractAnaerobically stabilized sludge from wastewater treatment is always a challenge from the environmental aspect of management. The agrarian environmental surroundings present a possibility for swift and efficient utilization of compost from anaerobically stabilized sludge in order to increase the quality of the biological product. With intensification of the composting procedure by means of the microbiological consortium Geocell‐1 (Cellvibrio sp., Pseudomonas fluorescens with the addition of micro‐ and macro‐elements), the results show that the compost obtained from stabilized sludge after inoculation is significantly improved in terms of moisture reduction (39–43%), while in the control compost, this value is significantly higher with 61%. The results of the pathogenic effect show a significant reduction in the number of fecal coliform (<1 × 103) and Enterococcus bacteria (<1 × 104) in the inoculated (treated) compost. With a slight decrease in the concentration of limiting factors such as As, Cd, Cu, a quality biological product can be achieved, which can be safely deposited on soil. The phytotoxicological germination test with white mustard (Sinapis alba) shows a higher number of sprouting plants with a mixture of treated compost and standard soil for flowers 1:1 and 1:4 compared to the control group.
Erlangen—An Important Center of Crystal Growth and Epitaxy: Major Scientific Results and Technological Solutions of the Last Four Decades
Authors: Friedrich Jochen , Müller Georg 
Published: October 2019

AbstractThis article describes the historic development of the Erlangen Crystal Growth Laboratory CGL from its beginnings in 1974 at the chair of Materials of Electrical Engineering (Department of Material Science) of the University of Erlangen–Nuremberg until its current status as a large department “Materials” of the Erlangen Fraunhofer‐Institute for Integrated Systems and Device Technology. Essential developments and scientific achievements in the various fields of crystal growth and epitaxy are presented from the early period until today.
On being nice and effective: Work‐related emotional intelligence and its role in conflict resolution and interpersonal problem‐solving
Authors: Krishnakumar Sukumarakurup , Perera Buddhika , Hopkins Kay , Robinson Michael D. 
Published: October 2019

AbstractPeople are thought to differ in their abilities to perceive, understand, and manage emotions, a construct termed emotional intelligence (EI). North Dakota emotional abilities test (NEAT), a test of EI based on the situation judgment test method, assesses EI applied to work settings. Three survey‐based studies examined and found that NEAT scores correlated positively with constructive motivations and behavioral intentions (Study 1; n = 94), conflict handling strategies favoring mutual interests (Study 2; n = 92), and helpful workplace behaviors, particularly under stressful conditions (Study 3; n = 90). These findings could possess particular value in domains such as conflict resolution and mediation.
Peacebuilding and transformational change in Nigeria's oil region
Authors: Okoi Obasesam 
Published: October 2019

AbstractThis article draws on primary sources to examine postconflict transformations in Nigeria's oil region. The overarching goal of the article is to evaluate the impact of Nigeria's disarmament, demobilization, and reintegration program and its effectiveness as a vehicle for peacebuilding in the oil region, focusing specifically on the changes it has brought to the lives of former insurgents at the cultural, intrapersonal, structural, and interpersonal (CISI) levels. This study introduces the CISI model of conflict transformation to put these changes into context and explain why they are crucial for understanding peacebuilding and transformational change.