bluuebunny/crossref_metadata_2025_split huggingface dataset:
Healthy at Home for COPD: An Integrated Digital Monitoring, Treatment, and Pulmonary Rehabilitation Intervention
Authors: O'Connor Laurel , Behar Stephanie , Tarrant Seanan , Stamegna Pamela , Pretz Caitlin , Shirshac Jeanne ,   Thomas Scornavacca2, Wilkie Tracey , Fisher Kimberly , Tigas Emil , Mullen Marie , Hyder Michael , Wong Steven , Savage Brendon , Toomey shaun , Wang Biqi , Zai Adrian , Alper Eric , Lindenauer Peter , Dickson Eric , Broach John , McManus David , Kheterpal Vik , Soni Apurv 
Published: November 2024

Abstract

Background: Chronic Obstructive Pulmonary Disease (COPD) is a leading cause of morbidity and mortality in the United States. Frequent exacerbations result in higher use of emergency services and hospitalizations, leading to poor patient outcomes and high costs.
Objective: Demonstrate the feasibility of a multimodal, digitally enhanced remote monitoring, treatment, and tele-pulmonary rehabilitation intervention among patients with COPD.
Methods: In this pilot clinical trial, community-dwelling adults with moderate-severe COPD were enrolled in a multimodal digital monitoring and treatment program including a Fitbit wearable device, study app that tracked COPD-related symptoms, on-demand mobile integrated health (MIH) services for acute home-based treatment, and tele-pulmonary-rehabilitation. Participants were enrolled in the program for six months. COPD severity and health-related quality of life assessments were performed at baseline, 3 months, and 6 months. Primary feasibility outcomes include recruitment and retention rate, and participant protocol fidelity, which were reported descriptively. Exploratory clinical outcomes included patient-reported quality of life, activation, and intervention satisfaction.
Results: Over 18 months, 1,333 patients were approached and 100 (7.5%) were enrolled (mean age 66, 52% female). Ninety-six participants (96%) remained in the study for the full enrollment period. Fifty-five (55%) participated in tele-pulmonary-rehabilitation. Participants wore the Fitbit for a median of 114 days (IQR 183.6) and 16.85 hours/day (4.05), resulting in a median of 1133 minutes (243) per day. Completion rates for scheduled instruments ranged from 78-93% . Nearly all participants (85%) performed COPD ecological momentary assessment at least once with a median of 4.85 recordings. On average, a 2.48-point improvement (p=0.03) in COPD Assessment Test Score was observed from baseline to study completion. The adherence and symptom improvement metrics were not associated with baseline patient activation measures.
Conclusions: A multimodal intervention combining preventative care, symptom and biometric monitoring, and home treatment was feasible in adults living with COPD. Participants demonstrated high protocol fidelity and engagement and reported improved quality of life.
Reveals of a Shifting Climate: A Regional Analysis of Rainfall and Temperature Trends at Mymensingh Division in Bangladesh (1950-2020)
Authors: Haque Md Khairul , Hassan Md Rakibul 
Published: November 2024

Abstract

Professional resource allocation and planning in response to climate change in developing regions such as the Mymensingh Division of Bangladesh requires comprehension of trends in temperature and precipitation over long periods of forecast. This is the reason why this study examines the temperature and precipitation from the years 1950 to 2020 in order to provide a reasonable view of local climatic conditions and facilitate the policymaking process. By using climactic research unit (CRU) TS data sets in creation of raster layers using ArcGIS tools we undertook data processing research which involved statistical analysis methods. Mann-Kendall test has generated a very encouraging result as it has found relative increase in annual precipitation, averaging about 2760.52 mm and oscillating between 1752 mm and 4338 mm. Kendall’s tau correlation τ = 0.156, p-value = 0.024, shows a possible change over a period of time. Slope of sen demonstrated that precipitation regime has increase by 1.9 mm annually. The analyses of autocorrelation and partial autocorrelation confirmed that the precipitation data upside and trends are clearly delineated. Progressive warming trend as regards the average annual temperature was observed, as the years went by, the average annual temperature increased from 24.77 0 c to 25.170c, more so in recent years where there have been high degree of warming. This study highlights the need for ongoing climate and the enhancement of global warming policies to prevent worsening situations.
Genetic Diversity and Population Structure of Turkish European Chestnut (Castanea sativa) Genotypes Assessed Using Start Codon Targeted Polymorphism (SCoT) Markers
Authors: Orman Erdal , Çakar Deniz , Alkan Mehtap , Özer Göksel , Güler Emrah , Gündoğdu Muttalip 
Published: November 2024

Abstract

The European chestnut (Castanea sativa) is an important nut crop that grows naturally in the Black Sea and Aegean regions of Turkey. This study examined the genetic diversity and population structure of chestnut genotypes from prominent regions in Turkey using Start Codon Targeted Polymorphism (SCoT) markers. A total of 44 Turkish chestnut genotypes from the Aegean, Marmara, and Black Sea regions, along with a control group of French variety, were analyzed. The SCoT primers underwent tests to select the most suitable ones, producing 8 selected amplified fragments, 65.34% of which were found to be polymorphic. The UPGMA and PCoA analyses showed clear discrimination between two populations based on their origins, which was supported by the population structure analysis. The AMOVA analysis revealed that 3% of the genetic variation was within populations and 97% was among individuals. The out-group (French variety) showed the furthest genetic similarity, and genetic similarity values decreased with increasing geographic distance. The SCoT primers successfully fingerprinted chestnut genotypes and could be used in future studies to analyze the phylogeny of chestnuts using genomic DNA.
Nitrous Oxide activates layer 5 prefrontal neurons via SK2 channel inhibition for antidepressant effect
Authors: Cichon Joseph , Joseph Thomas , Lu Xinguo , Wasilczuk Andrzej , Kelz Max , Mennerick Steven , Zorumski Charles , Nagele Peter 
Published: November 2024

Abstract

Nitrous oxide (N2O) induces rapid and durable antidepressant effects. The cellular and circuit mechanisms mediating this process are not known. Here we find that a single dose of inhaled N2O induces rapid and specific activation of layer V (L5) pyramidal neurons in the cingulate cortex of rodents exposed to chronic stress conditions. N2O-induced L5 activation rescues a stress-associated hypoactivity state, persists following exposure, and is necessary for its antidepressant-like activity. Although NMDA-receptor antagonism is believed to be a primary mechanism of action for N2O, L5 neurons activate even when NMDA-receptor function is attenuated through both pharmacological and genetic approaches. By examining different molecular and circuit targets, we identify N2O-induced inhibition of calcium-sensitive potassium (SK2) channels as a key molecular interaction responsible for driving specific L5 activity along with ensuing antidepressant-like effects. These results suggest that N2O-induced L5 activation is crucial for its fast antidepressant action and this effect involves novel and specific molecular actions in distinct cortical cell types.
Autoradiography of intracerebral tumours in the chick embryo model: A feasibility study using different PET tracers
Authors: Krause Sandra , Florea Alexandru , Choi Chang-Hoon , Worthoff Wieland A. , Heinzel Alexander , Fischer Saskia , Burda Nicole , Neumaier Bernd , Shah N. Jon , Lohmann Philipp , Mottaghy Felix , Langen Karl-Josef , Stegmayr Carina 
Published: November 2024

Abstract

Purpose: In addition to rodent models, the chick embryo model has gained attention for radiotracer evaluation. Previous studies investigated tumours on the chorioallantoic membrane (CAM), but its value for radiotracer imaging of intracerebral tumours has not yet been demonstrated.
Procedures: Human U87 glioblastoma cells and U87-IDH1 mutant glioma cells were implanted into the brains of chick embryos at developmental day 5. After 12-14 days of tumour growth, blood-brain-barrier integrity was evaluated using in vivo MRI contrast enhancement or ex vivo with Evans blue dye. The tracers O-(2-[18F]fluoroethyl)-L-tyrosine ([18F]FET) (n=5), 3,4-dihydroxy-6-[18F]-fluoro-L-phenylalanine ([18F]FDOPA) (n=3), or [68Ga] labelled quinoline-based small molecule fibroblast activation protein inhibitor ([68Ga]FAPI-46) (n=4) were injected intravenously if solid tumours were detectable in MRI. For time-activity curves for [18F]FET, additional micro PET (µPET) was performed. The chick embryos were sacrificed 60 minutes post-injection, and cryosections of the tumour-bearing brains were produced and evaluated with autoradiography and immunohistochemistry.
Results: Intracerebral tumours were produced with a 100 % success rate in viable chick embryos at experimental endpoint, however, 52% of chick embryos (n=85) did not survive the procedure on a long term. For the evaluated radiotracers, the tumour-to-brain ratios (TBR) derived from ex vivo autoradiography, as well as the tracer kinetics derived from µPET for intracerebral chick embryo tumours, were comparable to those previously reported in rodents and patients: TBRmean for [18F]FET was 1.69 ± 0.54 (n=5), and 3.8 for one hypermetabolic tumour and < 2.0 for two isometabolic tumors using [18F]FDOPA, with TBRmean of 1.92 ± 1,11 (n=3). The TBRmean of [68Ga]FAPI-46 for intracerebral chick embryo tumours was 19.13 ± 0.64 (n=4). In one of U87-MG tumours (n=5), an intact blood-tumour barrier was observed. Conclusions: Radiotracer imaging of intracerebral tumours in the chick embryo offers a fast model for the evaluation of radiotracer uptake, accumulation, and kinetics. Our results indicate a high comparability of chick embryo intracerebral tumour imaging to xenograft rodent models or brain tumour patients.
Impact of RNF213 p.R4810K variant on Postoperative Temporal Muscle Swelling Used in Encephalo-Myo- Synangiosis After Combined Revascularization for Moyamoya Disease
Authors: Mizushima Makoto , Ito Masaki , Uchino Haruto , Sugiyama Taku , Fujimura Miki 
Published: November 2024

Abstract

Postoperative neurological deterioration due to brain compression by the swollen temporal muscle pedicle used in encephalo-myo-synangiosis (EMS) is a potential complication of combined revascularization for Moyamoya disease (MMD). However, the factors contributing to this phenomenon remain poorly understood. This study aimed to identify factors associated with postoperative temporal muscle swelling following combined revascularization. A total of 37 consecutive combined revascularization using temporal muscle pedicle performed between 2021 and 2023 were analyzed. Postoperative temporal muscle volume was measured through serial CT scans on postoperative days (POD) 0, 1, 7, 14, and 30. Multiple regression analysis was performed to assess factors contributing to swelling, including RNF213p.R4810K variant, a known genetic risk for Asian MMD. Surgical outcomes and collateral vessel development were also examined. Results showed a significant increase in muscle pedicle volume on POD 1 and 7 across all 37 hemispheres, followed by a marked decrease by POD 30, compared to POD 0. These chronological volume changes were significant in adults (n=31) but not in pediatric patients (n=6). Multiple regression analysis identified the RNF213 p.R4810K as sole significant factor positively associated with maximal muscle volume (regression coefficient 0.485, P=0.0078). Favorable surgical outcomes were achieved in 36 of 37 cases (97.3%) over a mean follow-up of 2.2 years, with indirect collateral development confirmed in 27 adult (87%) and 6 pediatric (100%) hemispheres. Results suggest the RNF213 p.R4810K variant is associated with increased postoperative temporal muscle swelling after combined revascularization, especially in adult MMD patients, indicating a potential genetic influence on this complication.
Recent advancements in nanoscale materials from biomass waste demonstrate efficacy in removing Fe2+ and Ni2+ from water
Authors: Farouz Mohamed , Okil Mohamed , Mostafa Ayman M. , ElFaham Mohamed M. 
Published: November 2024

Abstract

Elevated concentrations of heavy metal ions are in many ways considered to be an affront to the aquatic ecosystems; their sources being attributed mainly to industries and agricultural sectors and, and a lesser extent, urban water runoff during storms. Heavy metal ions that are easily found in water sources include lead, mercury, chromium, cadmium, arsenic, and copper. These metals, if ingested or inhaled, cause many health hazards and present great risks to water bodies because they reduce the oxygen available to fish and other aquatic animals. One way to prevent this problem is to use nanoparticles at the nano level obtained from industrial and agricultural waste products for the removal of heavy metals from water. In the adsorption process, heavy metal ions tend to attach to the exterior surfaces of these nanoscale biomass particles, with possible removal from the aqueous phase. They also affirmed that the technical effectiveness of nanowaste biomass in water desalination reduces the availability of heavy metal contaminants in water in a relatively cheaper and more sustainable manner than conventional methods. In the present study, synthesized (45–60 nm) pomegranate nanoparticles (PGSN) were used as biosorbents, which yielded high removal performances of 85% for Fe²⁺ and 83% for Ni²⁺ ions. The biosorbent was characterized using zeta size and zeta potential analyses, Field Emission Scanning Electron Microscopy (FESEM), high-resolution transmission electron microscopy (HRTEM), Energy Dispersive X-ray Analysis (EDXA), Brunauer-Emmett-Teller (BET) surface analysis, and High-, X-ray diffraction (XRD).
Goal-oriented preoperative biliary drainage is more precise and conducive to seize the opportunity for pancreaticoduodenectomy
Authors: Cao Hongtao , Li Tianyu , Li Zeru , Zhao Bangbo , Liu Ziwen , Wang Weibin 
Published: November 2024

Abstract

Background
Preoperative biliary drainage (PBD) for selected patients with severe juandice has been shown to improve clinical conditions for pancreaticoduodenectomy (PD) and reduce the risk of post-pancreatectomy hemorrhage (PPH). However, the determination of an optimal end-point for PBD remains unclear. The aim of this research is to introduce the concept of goal-oriented biliary drainage, which may serve as a reasonable target and identify the optimal surgery time window.
Methods
The clinical data of 194 patients diagnosed with pancreatic cancer and obstructive jaundice were retrospectively analyzed. Serological laboratory examinations including total bilirubin (TBIL) within one week before PBD and PD were recorded and labeled as TBIL-pre and TBIL-post respectively. PBD and PD were performed by experienced medical teams. PPH with grade B and C were enrolled.
Results
TBIL-post less than 93.0µmol/L (sensitivity 83.78%, specificity 72.61%) or TBIL decay more than 68.5% (sensitivity 86.49%, specificity 69.43%) identified through ROC curves and multivariate analysis were independent protective factors for reducing the risk of PPH (OR 0.234 and 0.191 retrospectively, P<0.05) and were established as PBD goals. The Kaplan-Meier curves demonstrated the median time to achieve both PBD goals was 3 weeks. Additionally, the proportion of patients achieving both goals failed to increase with the PBD duration over 6 weeks (P > 0.05). The proportion of TBIL-post ≤ 93.0µmol/L (70.8% vs. 51.1%, P<0.05) and TBIL decay ≥ 68.5% (67.0% vs. 50.0%, P<0.05) were higher in EBS group than those in PTCD group.
Conclusion
A goal-oriented PBD with the target of TBIL ≤ 93.0µmol/L or TBIL decay ≥ 68.5% can reduce the morbidity of PPH. In general conditions, PBD duration within 3 weeks would be sufficient, while exceeding the duration beyond 6 weeks could not provide additional benefits. Both EBS and PTCD are safe and EBS is more recommended due to its superior performance in achieving the goals.
Relationship Between Age, Conditioning Intensity, and Outcome After Allografting in Adults Age ≥60 Years with AML
Authors: Vo Phuong , Sandmaier Brenda , Othus Megan , ali naveed , Rodríguez-Arbolí Eduardo , Orvain Corentin , Davis Chris , Basom Ryan , Storb Rainer , Walter Roland 
Published: November 2024

Abstract

Methodological advancements now allow older adults with AML to receive allografts although conflicting data exist regarding relative outcomes across age groups and benefits of different conditioning intensities. We retrospectively analyzed 495 adults aged 60–64 (n = 184), 65–69 (n = 189), or ≥ 70 (n = 122) who underwent allogeneic HCT for AML in remission at our institution from 2006 to 2023. There were no significant differences in relapse or relapse-free survival (RFS) among the 3 age cohorts after multivariable adjustment. Patients aged ≥ 70 years had a higher risk of non-relapse mortality (NRM) than those aged ≥ 60–64 (P = 0.022) but their overall survival (OS) was only statistically non-significantly shorter (P = 0.11). There was an important interplay between age, conditioning intensity, and outcomes. Age ≥ 70 years was associated with a higher risk of relapse (hazard ratio [HR] = 3.47; P = 0.012) and NRM (HR = 3.88; P = 0.001) with reduced intensity conditioning (RIC), leading to shorter RFS (HR = 3.79; P < 0.001) and OS (HR = 3.46; P < 0.001), while no association was found with nonmyeloablative conditioning. Conversely, patients aged 60–64 and 65–69, not those aged ≥ 70, had a significantly lower risk of relapse with RIC, but NRM risk increased with age. Our findings support allogeneic HCT for adults with AML in remission even if aged beyond 70, especially with nonmyeloablative conditioning.
Dynamics effect of the droplet impacting on heated solid surface
Authors: Dou Xiaoxiao , Wang Chun , Zhang Guangwen , Lang Xuqing , Cheng Yiwei , Zheng Yi , Jiao JinQing 
Published: November 2024

Abstract

Dynamic effect of the droplet impacting high-temperature surfaces affects their cooling and heat transfer efficiency. In this paper, the effects of viscosity, surface tension, and landing speed of droplets on the maximum diffusion factor were studied through experiments. Four typical impact states during droplet impact to surfaces of different temperatures are observed, including spreading, bubble nucleation, transition from bubble to atomization, and fogging, and a dimensionless mathematical model is established to describe the relationship between droplet physical and kinetic parameters and the spreading state, and an empirical correlation equation for predicting the dimensionless maximum spreading diameter based on the experimental results is presented, which provides theoretical basis for the calculation of the cooling efficacy of the droplet impact on high temperature surfaces. The empirical correlation formula for predicting the dimensionless maximum spreading diameter based on experimental results provides a theoretical basis for calculating the cooling efficiency of droplet impact on high temperature surface.
Associations Between Perceived Stress and Cortisol Biomarkers in Predominantly Latino Adolescents
Authors: Sanogo Fatimata , Ruth Avaion , Cortessis Victoria K. , Ding Li , Watanabe Richard M. , Weigensberg Marc J. 
Published: November 2024

Abstract

Objective
The relationship between cortisol and perceived stress is poorly understood. We sought to determine whether perceived stress is associated with cortisol biomarkers in adolescents.
Methods
We examined 229 adolescents (mean age = 15.8 years). We measured perceived stress with the 14-item Perceived Stress Scale (PSS) questionnaire, serum cortisol (sCOR), salivary Cortisol Awakening Response (CAR: 30-minute post-awakening - awakening), salivary Diurnal Cortisol Slope (DCS: evening-awakening), and total daily salivary cortisol (TDC). We used multivariable linear regression to estimate baseline associations between PSS, TDC, sCOR, and FBG. We used mixed effects linear regression to estimate baseline associations between PSS and CAR and DCS. We tested twelve-week longitudinal associations between PSS and cortisol biomarkers using random effects regression. Analyses were adjusted for age, gender, and BMI.
Results
There were statistically significant associations between PSS and TDC (beta= -104.36 ± 34.3; p = 0.002) at baseline and between PSS and DCS at 12 weeks (beta= -0.058 ± 0.02; p = 0.01), but no association between PSS and sCOR or CAR (p > 0.26 for all) at baseline or 12-weeks. There were no associations between change in PSS and change in cortisol biomarkers longitudinally.
Conclusion
In adolescents, perceived stress measured by the PSS was inconsistently associated with TDC and DCS, and consistently unassociated with CAR and sCOR. Studies reporting on PSS outcomes should exercise caution when making conclusions about cortisol biomarkers. There’s a need for an instrument that captures a global measure of perceived stress and is sensitive to HPA functioning.
Contextual learning requires rapid Ser408-409 phosphorylation of the GABAA receptor β3 subunit and GABAergic plasticity at hippocampal CA1 synapses
Authors: Sakimoto Yuya , Yang Y , Kida Hiroyuki , Mitsushima Dai 
Published: November 2024

Abstract

Contextual learning requires plasticity at both AMPA receptor-mediated excitatory and GABAA receptor-mediated inhibitory synapses in CA1 neurons, but detailed mechanisms of learning-induced plasticity at GABAA receptor-mediated synapses have been unclear. To further investigate the causal relationship between Ser408–409 phosphorylation, GABAergic plasticity, and learning, we developed a novel peptide-based phosphorylation inhibitor targeting the Ser408–409 site using a cell-permeable HIV-tagged peptide (Tat pep β3-SS). In the behavioral analysis, the peptide was microinjected bilaterally into CA1 under freely moving conditions 60 min before IA training. Tat-pep β3-SS but not Tat-pep β3-AA significantly impaired contextual learning performance without altering sensory or motor functions. In Western blot analysis, injection of Tat-pep β3-SS but not Tat-pep β3-AA into CA1 attenuated the rapid phosphorylation of Ser408–409. In patch clamp analysis, we microinjected Tat-pep β3-SS-FITC into CA1 and successfully prevented the training-induced increase in postsynaptic Cl- current of GABAA receptors in labeled CA1 neurons. For histological analysis, membrane clusters of GABAA receptors were reduced in Tat pep β3-SS-positive neurons compared to Tat pep β3-AA-positive neurons. Our study provides novel evidence that contextual learning requires GABAA receptor-mediated plasticity at inhibitory synapses.
China’s business environment and firm productivity: A meta-analysis
Authors: Lyu Jinge , Xu Haiping , Zhang Chuqiao , Jiang Qunyong , Wei Haixia , Zhang Shenfan , Zhang Xingyu 
Published: November 2024

Abstract

Business environment and firm productivity are inextricably linked and there are many unsolved questions about their relations. The study aims to scrutinize the relationship between business environment and firm productivity by synthesizing existing empirical studies and utilizing a meta-analysis method. Through a systematic review of the literature, this paper identifies 52 pertinent studies from 2014 to 2023 in China, and obtains 52 independent samples. The primary finding corroborates that a favorable business environment exert a positive impact on firm productivity. Furthermore, it reveals that the six dimensions of business environment have different degrees of influence on firm productivity. Additionally, the findings indicate that factors such as firm size, nature, and type serve as moderators in the relationship between business environment and firm productivity. In general, the results of the study can provide decision makers with insights into optimizing productivity in dynamic business environments, and offer prospects for future research directions.
JEL Classification: D20·F10·G38·H20·H54