bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hypertensive pregnancy disorder, an under‐recognized women specific risk factor for heart failure?
Authors: Ghossein‐Doha Chahinda , Thilaganathan Basky , Vaught Arthur Jason , Briller Joan E. , Roos‐Hesselink Jolien W. 
Published: November 2024

AbstractDuring pregnancy, the maternal cardiovascular (CV) system undergoes major haemodynamic alterations ensuring adequate placental perfusion and a healthy pregnancy course. Hypertensive disorders of pregnancy (HDP) occur in almost 10% of gestations and preeclampsia, a more severe form, in 3–4%. Women with HDP demonstrated impaired myocardial function, biventricular chamber dysfunction and adverse biventricular remodelling. Shortly after delivery, women who experienced HDP express increased risk of classic CV risk factors such as hypertension, renal disease, abnormal lipid profile, and diabetes. Within the first two decades following a HDP, women experience increased rates of heart failure, chronic hypertension, ischaemic heart and cerebral disease. The mechanism underlying the relationship between HDP in younger women and CV disease later in life could be explained by sharing pre‐pregnancy CV risk factors or due to a direct impact of HDP on the maternal CV system conferring a state of increased susceptibility to future metabolic or haemodynamic insults. Racial disparities in CV risk and social determinants of health also play an important role in their remote CV risk. Although there is general agreement that women who suffered from HDP should undertake early CV screening to allow appropriate prevention and timely treatment, a screening and intervention protocol has not been standardized due to limited available evidence. In this review, we discuss why women with hypertensive pregnancy may be disproportionately affected by heart failure with preserved ejection fraction and how cardiac remodelling during or after pregnancy may influence its development.
Synthesis of Highly Fluorescent Thiazole Fused Benzo[a] Carbazoles by Sunlight Driven Photocyclization of Indolylthiazoles
Authors: Bhaumick Prabhas , Mondal Nurabul , Choudhury Lokman H. 
Published: November 2024

AbstractHerein we report for the first time a sunlight‐driven, irreversible photocyclization reaction of indole‐linked trisubstituted thiazoles, for the synthesis of highly fluorescent thiazole‐fused benzo[a]carbazoles using a mixture of solvents (CH3CN: DMSO; 3 : 1). Ring opening of indole moiety was observed in the case of thiazole derivatives having 2‐methyl indole substituents. Under similar reaction conditions, photocyclization of trisubstituted thiazoles having cyclic 1,3‐dicarbonyls in place of indole moiety also worked. This reaction provides products having two medicinally important moieties thiazole and benzocarbazoles. We have studied the photophysical properties of all the products and found that most of the synthesized products have very good fluorescence quantum yields.
Strategic Patent Portfolio Management in the Sodium‐Ion Battery Industry: Navigating Innovation and Competition
Authors: Jayaraman Vinoth Kumar , Prakash Annigere S. 
Published: November 2024

ABSTRACTIn the rapidly evolving landscape of energy storage technologies, sodium‐ion batteries (SIBs) have emerged as promising alternatives to conventional lithium‐ion batteries. SIBs exhibit moderate to high specific energy ranging from approximately 70 to 170 Wh/kg, ensuring suitability for diverse applications. Furthermore, with their abundance of raw materials and potential for lower costs, sodium‐ion batteries are attracting significant interest from researchers, manufacturers, and investors. This heightened interest is evidenced by the exponential growth in the number of patents filed for SIBs, totalling 142 648 patents. This surge in patent filings underscores the growth pattern of SIBs as promising alternatives in the energy storage landscape. In this dynamic environment, securing and maintaining a robust patent portfolio is imperative for companies and innovators to establish a competitive edge, enabling them to capitalize on the increasing market demand. This perspective examines the strategies involved in building, protecting, and managing a robust patent portfolio as well as provides intellectual property challenges and patent filing opportunities in SIB technologies.
Synergistic Effect and Mechanism of Combined Astaxanthin and Curcumin Administration on Ovarian Function in PCOS Mice
Authors: Zhang Gao , He Man , Wang Zun , Zheng Jinrong , Zhao Dan , Nie Li , Yuan Dongzhi , Zhao Ziyu , Wang Wei , Yue Limin 
Published: November 2024

ABSTRACTTo investigate the synergistic effect of astaxanthin and curcumin on ovarian function in polycystic ovary syndrome (PCOS) mice and to elucidate the underlying mechanisms, fifty 4‐week‐old female mice were randomly divided into five groups: (i) normal control group; (ii) PCOS model group; (iii) PCOS + astaxanthin group; (iv) PCOS + curcumin group; and (v) PCOS + astaxanthin–curcumin. Throughout the study, various parameters were meticulously evaluated, including serum levels of key reproductive hormones (testosterone (T), estradiol (E2), follicle‐stimulating hormone (FSH), luteinizing hormone (LH), and anti‐Müllerian hormone (AMH)), as well as monitoring alterations in the estrous cycle, follicle development, and ovulation rates. Additionally, markers of oxidative stress and inflammation were measured. Findings revealed that PCOS mice exhibited disordered estrous cycle, polycystic ovarian morphologies, abnormal serum reproductive hormones and lipid metabolism, heightened oxidative stress, and augmented inflammatory responses. Notably, upon administration of the combined astaxanthin and curcumin, PCOS mice exhibited significant improvements in their estrous cyclicity and ovarian histology. The treatment led to a significant reduction in serum total cholesterol (TC) levels and normalization of T, E2, FSH, LH, and AMH levels. Moreover, there was a marked decrease in the levels of serum reactive oxygen species (ROS) and malondialdehyde (MDA), indicating attenuation of oxidative stress. Concurrently, the activity of the antioxidant enzyme catalase (CAT) significantly increased, while proinflammatory cytokines interferon‐γ (IFN‐γ) and interleukin‐6 (IL‐6) in the ovarian tissue were notably decreased. The combined treatment also resulted in a substantial increase in the number of ova and a significant decline in the rate of abnormal ova, with these therapeutic effects proving more effective compared to either astaxanthin or curcumin alone. In conclusion, the co‐administration of astaxanthin and curcumin demonstrated a remarkable effect in improving abnormal lipid metabolism and restoring reproductive endocrine functions in PCOS mice. Furthermore, it effectively mitigated systemic and local oxidative stress and chronic inflammatory injury, thereby promoting follicular growth and enhancing ovulatory function in the context of PCOS.
An Inflammatory Myofibroblastic Tumor With a Novel ALKV1180L Mutation Leading to Acquired Resistance to Tyrosine Kinase Inhibitors
Authors: Sharpe Brittney , Green Donald C. , Tafe Laura J. , Wasp Garrett T. , Kerr Darcy A. , Dashti Nooshin K. 
Published: November 2024

ABSTRACTInflammatory myofibroblastic tumor (IMT) is a rare mesenchymal neoplasm that can locally recur and potentially metastasize. Approximately 50% of IMTs harbor rearrangements in the gene encoding anaplastic lymphoma kinase (ALK), a receptor tyrosine kinase that can be therapeutically targeted with tyrosine kinase inhibitors (TKIs). With successful application of TKI in ALK‐positive nonsmall cell carcinoma (NSCLC), ALK inhibitors are often first‐line treatments for patients with unresectable or metastatic IMTs. Although acquired resistance to these agents may develop, resistance mechanisms are sparsely reported for IMTs. Here we report a case of a 71 year‐old man with metastatic pulmonary IMT harboring a DCTN1::ALK fusion that progressed during alectinib TKI treatment. Whole exome sequencing of an enlarging metastatic lesion in right 4th rib revealed a novel p.V1180L mutation in the ALK tyrosine kinase domain as the mechanism of acquired resistance. To our knowledge, this is the first report of acquired p. V1180L mutation in IMTs treated with TKIs. In cases of ALK‐positive IMTs that progress on TKI therapy, targeted sequencing for acquired ALK mutations may inform clinical decisions to adopt second‐line therapeutic strategies.
Wear, Material Transfer, and Electrocautery Damage Are Ubiquitous on CoCrMo Femoral Knee Retrievals
Authors: Kurtz Peter W. , Kurtz Michael A. , Aslani Shabnam , Taylor Lilliana M. , Goodwin Charley M. , MacDonald Daniel W. , Piuzzi Nicolas S. , Mihalko William M. , Kurtz Steven M. , Gilbert Jeremy L. 
Published: November 2024

ABSTRACTDespite high total knee arthroplasty (TKA) survivorship after 10 years (92%–99%), a gap persists where patient satisfaction lags clinical success. Additionally, while cobalt chrome molybdenum (CoCrMo) use decreases in primary total hip arthroplasty, the alloy continues to be widely used in TKA femoral components. In vivo, CoCrMo degradation may be associated with adverse local tissue reactions (ALTR) and compared with the hip, the damage mechanisms that may release metal in the knee and the potential biological effects remain poorly understood. In this study, we characterized the damage on 50 retrieved CoCrMo femoral knee implants paired with 19 titanium alloy and 31 CoCrMo tibial baseplates. We asked (1) what damage modes can release CoCrMo debris in vivo from femoral components and (2) how frequently does the damage occur? First, we developed a semiquantitative scoring system for abrasive wear. Then, we characterized damage modes on CoCrMo femoral implants using digital optical microscopy (DOM), scanning electron microscopy (SEM), and energy dispersive X‐ray spectroscopy (EDS). We found that wear, electrocautery damage, and Ti‐6Al‐4V material transfer were ubiquitous. Of the 50 CoCrMo femoral implants we investigated, we documented wear on 100% (n = 50/50), electrocautery damage on 98% (n = 49/50), and Ti‐6Al‐4V material transfer to the posterior condyles on 95% (n = 18/19). Our results suggest that these damage modes may be more prevalent than previously thought and may act as metal release mechanisms in vivo.
An Annual Review of Important Apheresis Articles From the American Society for Apheresis Attending Physician Subcommittee
Authors: Tanhehco Yvette C. , Alsammak Mohamed , Wu Ding Wen , Costa Victoria , Chhibber Vishesh , Levenbrown Yosef , Li Yanhua , Lu Wen , Mattiazzi Adela D. , Stephens Laura D. , Noland Daniel K. , Martin Marisa C. Saint , Singh Nirupama , Zantek Nicole D. , Becker Joanne , Wehrli Gay 
Published: November 2024

ABSTRACTIn this first annual review article, the American Society for Apheresis (ASFA) Attending Physician Subcommittee (APSc) of the Physicians' Committee (PC) curated key apheresis literature in 2023 and presented their choices for the 10 most seminal apheresis articles. PubMed and OVID search engines were used to identify manuscripts from four topic areas: donor apheresis, therapeutic apheresis, education, and cellular therapy. To further identify seminal criteria, they had to present at least one of the following: novel findings, practice‐altering outcomes, international scope, randomized controlled trial, relevant to current clinical practice, and/or provide evidence for category III or IV indications based on the ASFA ninth special issue of the Guidelines on the Use of Therapeutic Apheresis in Clinical Practice‐Evidence‐Based Approach. Inclusion criteria included: full‐length, peer‐reviewed, English language, and human subjects. Case reports, review articles, and meta‐analyses were excluded.
Metagenomic Analysis Identifies Sex‐Related Gut Microbial Functions and Bacterial Taxa Associated With Skeletal Muscle Mass
Authors: Park Hang A. , Sung Joohon , Chang Yoosoo , Ryu Seungho , Yoon Kyung Jae , Kim Hyung‐Lae , Kim Han‐Na 
Published: November 2024

ABSTRACTBackgroundThis study aimed to explore the association between gut microbiota functional profiles and skeletal muscle mass, focusing on sex‐specific differences in a population under 65 years of age.MethodsStool samples from participants were analysed using metagenomic shotgun sequencing. Skeletal muscle mass and skeletal muscle mass index (SMI) were quantified (SMI [%] = total appendage muscle mass [kg]/body weight [kg] × 100) using bioelectrical impedance analysis. Participants were categorized into SMI quartiles, and associations between gut microbiota, functional profiling and SMI were assessed by sex, adjusting for age, BMI and physical activity.ResultsThe cohort included 1027 participants (651 men, 376 women). In men, Escherichia coli (log2 fold change 3.08, q = 0.001), Ruminococcus_B gnavus (log2 fold change 2.89, q = 0.014) and Enterocloster sp001517625 (log2 fold change 2.47, q = 0.026) were more abundant in the lowest SMI compared to the highest SMI group. In contrast, Bifidobacterium bifidum (log2 fold change 3.13, q = 0.025) showed higher levels in the second lowest SMI group in women. Microbial pathways associated with amino acid synthesis (MET‐SAM‐PWY: log2 fold change 0.42; METSYN‐PWY: log2 fold change 0.44; SER‐GLYSYN‐PWY: log2 fold change 0.20; PWY‐5347: log2 fold change 0.41; P4‐PWY: log2 fold change 0.53), N‐acetylneuraminate degradation (log2 fold change 0.43), isoprene biosynthesis (log2 fold change 0.20) and purine nucleotide degradation and salvage (PWY‐6353: log2 fold change 0.42; PWY‐6608: log2 fold change 0.38; PWY66‐409: log2 fold change 0.52; SALVADEHYPOX‐PWY: log2 fold change 0.43) were enriched in the lowest SMI in men (q < 0.10). In women, the second lowest SMI group showed enrichment in energy‐related pathways, including lactic acid fermentation (ANAEROFRUCAT‐PWY: log2 fold change 0.19), pentose phosphate pathway (PENTOSE‐P‐PWY: log2 fold change 0.30) and carbohydrate degradation (PWY‐5484: log2 fold change 0.31; GLYCOLYSIS: log2 fold change 0.29; PWY‐6901: log2 fold change 0.27) (q < 0.05).ConclusionsThis study highlights sex‐specific differences in gut microbiota and functional pathways associated with SMI. These findings suggest that gut microbiota may play a role in muscle health and point toward microbiota‐targeted strategies for maintaining muscle mass.
Ultrastructural and Functional Organization of Maxillary Palps in Ladybird Species (Coleoptera: Coccinellidae) With Different Feeding Preferences
Authors: Sevarika Milos , Romani Roberto 
Published: November 2024

ABSTRACTInsects antennae serve as their primary sensory organs, playing a crucial role both in intra‐ and interspecific communication, a trait shared across the entire class Insecta. Representatives of Coccinellidae (ladybird) are known for being important natural enemies of economically relevant pests, and occasionally for being pests themselves. In this study, we investigated the ultrastructural organization of maxillary palps in several ladybird species exhibiting different feeding preferences, including entomophagous species (Harmonia axyridis, Scymnus interruptus, Delphastus catalinae, Cryptolaemus montrouzieri, Ceratomegilla undecimnotata, Propylea quatuordecimpunctata) and phytophagous species (Subcoccinella vigintiquatuorpunctata). We analyzed the ultrastructure of the maxillary palps using scanning and transmission electron microscopy. In all species, the maxillary palps were segmented, with the main sensory area located at the apical part of the enlarged distal segment. Our investigation revealed the presence of five distinct sensilla types on the maxillary palps, including uniporous, multiporous, campaniform, trichoidea, and digitiform sensilla. Interestingly, the sensilla shared a similar morphology across the investigated species. Uniporous and multiporous sensilla were the most abundant and were exclusively located in the apical sensory area. Campaniform sensilla were located on the apical sensory area, but positioned along the marginal zone, surrounding the area occupied by uniporous and multiporous sensilla. Digitiform sensilla were positioned in a restricted area of the dorsal side of the last palpomere. Our study hypothesizes that in Coccinellidae, maxillary palps play the role of primary sensory organ, along with the antennae. The comprehensive data presented here lay a robust foundation for further investigations into the role of maxillary palps in the chemical ecology of ladybirds.
Species behavioral characteristics lead to unique fragmentation threats: The Nubian ibex as a case study
Authors: Tichon Jonathan , Freiman Elyasaf , Spiegel Orr , Baruchi Erez , Atar Aviam , Lapid Roi , King Roni , Bar‐David Shirli , Saltz David 
Published: November 2024

AbstractThe behavioral characteristics of species may result in certain populations being inherently more susceptible to fragmentation. For example, species exhibiting spatial sexual segregation or those constrained to elongated and narrow habitats. We studied the fragmentation threats, spatial dynamics, resource utilization, and movement ecology of a particularly vulnerable species that is both sexually segregated and constrained to elongated and narrow habitat—the north Judean Desert population of Nubian ibex (Capra nubiana). From 2016‒2020 we tracked 48 marked ibex (27 male, 21 female), of which 38 (20 male, 18 female) also had global position system (GPS) collars. Using GPS‐collar and camera‐trap data in zones delineated around perennial water sources (PWSs), we calculated ibex drinking frequencies and individual utilization distributions by season and sex, focusing on their overall (95% isopleth) and core (50% isopleth) home ranges. We quantified joint space use between sexes using a utilization distribution overlap index (UDOI) and ibex daily movements and space use via movement indices. Female groups formed philopatric activity centers that were anchored around PWSs year‐round and arranged in a metapopulation‐like structure, with no female movement detected between them. Conversely, movement of adult males changed seasonally, with the cores of male groups anchored around PWSs only during the dry season, and long‐range movement between female activity centers during the rut. Female groups also spent more time at steeper terrain and higher elevations compared with male groups. Outside the rut, groups of males and groups of females exhibited minimal joint space use (i.e., average dry season UDOI was 0.06). These patterns indicate high sensitivity of this population to intersexual fragmentation by obstacles (physical or virtual). Management strategies to mitigate fragmentation threats for such populations should be sex‐specific and landscape‐oriented.
Self‐Induced Nasal Septal Perforation: Rhinotillexomania—A Different Entity From Nose Picking
Authors: Alobid Isam , Arango Cabezas Natalia , Yuen‐Ato Katherine C. , Hopkins Claire , Rojas‐Lechuga María Jesús 
Published: November 2024

BackgroundNose picking is a common habit that rarely leads to mutilating self‐injury. It is important to distinguish between rhinotillexomania (compulsive nose picking) as a disease and nose picking that results in or contributes to nasal septal perforation (NSP). The aim of this study is to investigate the impact of rhinotillexomania and NSP repair on sinonasal symptoms and quality of life (QoL).Methodology/PrincipalPatients with symptomatic NSP due to rhinotillexomania and candidates for surgical repair were included. Sinonasal symptoms and QoL were measured using a visual analogue scale (VAS), Sinus CT scan, Barcelona Smell Test 24 (BAST‐24), Sinonasal outcome test (SNOT‐22), Nasal Obstruction Symptom Evaluation (NOSE), NOSE‐Perf, and Medical Outcome Study Short Form (SF‐36). Healthy volunteers without sinonasal disorders (n = 43) were also included.ResultsA total of 37 patients with Rhinotillexomania (20 male [54.1%]; mean age, 49.2 years [SD 15.4]) were recruited. Totally 32 patients (86.5%) had NSP with the posterior border anterior to the incisive canal. Follow‐up data were registered for 29 patients with a mean follow‐up duration of 22.1 months (standard deviation, SD 16.7). The overall success rate of NSP repair was 96.6%. Patients experienced significant improvement in sinonasal symptoms and QoL after surgery.ConclusionsRhinotillexomania is a distinct entity from nose picking. Multidisciplinary approach including behavior therapy and NSP repair are considered the best approaches to relieve sinonasal symptoms. Placing nasal silicone sheets is recommended when the diagnosis of rhinotillexomania is confirmed. The greater palatine artery flap combined with inverted edges appears to be the most effective approach.Level of EvidenceLevel 3 Laryngoscope, 2024
Gut microbiota in health and disease: advances and future prospects
Authors: Zhang Yusheng , Wang Hong , Sang Yiwei , Liu Mei , Wang Qing , Yang Hongjun , Li Xianyu 
Published: November 2024

AbstractThe gut microbiota plays a critical role in maintaining human health, influencing a wide range of physiological processes, including immune regulation, metabolism, and neurological function. Recent studies have shown that imbalances in gut microbiota composition can contribute to the onset and progression of various diseases, such as metabolic disorders (e.g., obesity and diabetes) and neurodegenerative conditions (e.g., Alzheimer's and Parkinson's). These conditions are often accompanied by chronic inflammation and dysregulated immune responses, which are closely linked to specific forms of cell death, including pyroptosis and ferroptosis. Pathogenic bacteria in the gut can trigger these cell death pathways through toxin release, while probiotics have been found to mitigate these effects by modulating immune responses. Despite these insights, the precise mechanisms through which the gut microbiota influences these diseases remain insufficiently understood. This review consolidates recent findings on the impact of gut microbiota in these immune‐mediated and inflammation‐associated conditions. It also identifies gaps in current research and explores the potential of advanced technologies, such as organ‐on‐chip models and the microbiome–gut–organ axis, for deepening our understanding. Emerging tools, including single‐bacterium omics and spatial metabolomics, are discussed for their promise in elucidating the microbiota's role in disease development.
SIW Broadband Circularly Polarized High‐Gain Low‐Profile Magneto‐Electric Dipole Antenna Array
Authors: Xu Juan , Xie Yue , Zhao Jianping 
Published: November 2024

ABSTRACTThis study presents a substrate integrated waveguide (SIW) broadband circularly polarized (CP) high‐gain low‐profile magneto‐electric dipole antenna array. The antenna array is characterized by wide impedance bandwidth (IBW), novel CP operating principle, small form factor, and good radiation performance. First, the antenna element consists of a two‐layer dielectric substrate, two pairs of magneto‐electric dipoles, and a SIW cavity coupled and fed through a cross‐shaped rectangular slit. To achieve a wide CP bandwidth (BW), a pair of magneto‐electric dipoles is rectangularly chamfered and then an “L” type parasitic patch is introduced. The simulation results show that the antenna element has an axial ratio (AR) BW of 14.2% in the 31.48–36.16 GHz range, the IBW in the 29.08–35.98 GHz range is 21.2%, and the gain is greater than 8 dBic in all bands. The antenna exhibits stable patterns and wide overlap IBW (31.48–35.98 GHz). Then, a planar 2 × 2 antenna array fed by a one‐part‐four SIW power divider was designed, fabricated, and measured. The measured results show that the array has an ARBW of 14% in the range of 31.29−35.83 GHz, an IBW of 21.8% in the range of 29.28–35.83 GHz, and a peak gain of 14.1 dBic.