bluuebunny/crossref_metadata_2025_split huggingface dataset:
Maternal preconception weight trajectories, pregnancy complications and offspring’s childhood physical and cognitive development
Authors: Adane A. A. , Mishra G. D. , Tooth L. R. 
Published: August 2018

AbstractThere is limited evidence on the association between maternal preconception body mass index (BMI) trajectories and pregnancy complications and child development. This study examined the relationships of maternal BMI trajectories, diabetes and hypertensive disorders during pregnancy and offspring’s childhood physical and cognitive development. Data were from the Australian Longitudinal Study on Women’s Health and the Mothers and their Children’s Health study (n=771). Women’s preconception BMI trajectories were identified using group-based trajectory modelling. Children’s physical and cognitive development (up to the average age of 5 years) were obtained from the Ages and Stages Questionnaire (suspected gross motor delay) and the Australian Early Development Census (AEDC). Generalized estimating equation models, adjusted for maternal sociodemographic and lifestyle factors, were used for analyses. Three distinct BMI trajectories were identified (normative, chronically overweight and chronically obese). Children born to chronically obese women were more likely to be classified as developmentally vulnerable/at-risk on AEDC domains; gross and fine motor skills [risk ratio (RR)=1.64, 95% confidence interval (CI): 1.04, 2.61] and communication skills and general knowledge (RR=1.71, 95% CI: 1.09, 2.68). They also had an elevated risk of suspected gross motor delay (RR=2.62, 95% CI: 1.26, 5.44) compared with children born to women with a normative BMI trajectory. Maternal diabetes or hypertensive disorders during pregnancy were not associated with child outcomes. Maternal preconception BMI trajectories were associated with poorer childhood development. This study finding underscores the importance of excessive weight gain prevention throughout the reproductive stage of life.
Fracture Advancing Step Tectonics Observed in the Yuha Desert and Ocotillo, CA, Following the 2010 Mw7.2 El Mayor‐Cucapah Earthquake
Authors: Donnellan Andrea , Parker Jay , Heflin Michael , Lyzenga Gregory , Moore Angelyn , Ludwig Lisa Grant , Rundle John , Wang Jun , Pierce Marlon 
Published: August 2018

AbstractUninhabited aerial vehicle synthetic aperture radar (UAVSAR) observations 2009–2017 of the Yuha Desert area and Global Positioning System (GPS) time series encompassing the region reveal a northward migrating pattern of deformation following the 4 April 2010 Mw7.2 El Mayor‐Cucapah (EMC) earthquake. The north end of the EMC rupture exhibits an asymmetric pattern of deformation that is substantial and smooth northeast of the rupture and limited but with surface fracturing slip northwest. The earthquake triggered ~1 cm of surface coseismic slip at the Yuha fault, which continued to slip postseismically. 2.5 cm of Yuha fault slip occurred by the time of the 15 June 2010 Mw5.7 Ocotillo aftershock and 5 cm of slip occurred by 2017 following a logarithmic afterslip decay 16‐day timescale. The Ocotillo aftershock triggered 1.4 cm of slip on a northwest trend extending to the Elsinore fault and by 7 years after the EMC earthquake 2.4 cm of slip had accumulated with a distribution following an afterslip function with a 16‐day timescale consistent with other earthquakes and a rate strengthening upper crustal sedimentary layer. GPS data show broad coseismic uplift of the Salton Trough and delayed postseismic motion that may be indicative of fluid migration there and subsidence west of the rupture extension, which continues following the earthquake. The data indicate that the Elsinore, Laguna Salada, and EMC ruptures are part of the same fault system. The results also suggest that north‐south shortening and east‐west extension across the region drove fracture advancing step tectonics north of the EMC earthquake rupture.
Elucidation of glutamine lipid biosynthesis in marine bacteria reveals its importance under phosphorus deplete growth in Rhodobacteraceae
Authors: Smith Alastair F , Rihtman Branko , Stirrup Rachel , Silvano Eleonora , Mausz Michaela A , Scanlan David J , Chen Yin 
Published: August 2018

Abstract
Marine microorganisms employ multiple strategies to cope with transient and persistent nutrient limitation, one of which, for alleviating phosphorus (P) stress, is to substitute membrane glycerophospholipids with non-P containing surrogate lipids. Such a membrane lipid remodelling strategy enables the most abundant marine phytoplankton and heterotrophic bacteria to adapt successfully to nutrient scarcity in marine surface waters. An important group of non-P lipids, the aminolipids which lack a diacylglycerol backbone, are poorly studied in marine microbes. Here, using a combination of genetic, lipidomics and metagenomics approaches, we reveal for the first time the genes (glsB, olsA) required for the formation of the glutamine-containing aminolipid. Construction of a knockout mutant in either glsB or olsA in the model marine bacterium Ruegeria pomeroyi DSS-3 completely abolished glutamine lipid production. Moreover, both mutants showed a considerable growth cost under P-deplete conditions and the olsA mutant, that is unable to produce the glutamine and ornithine aminolipids, ceased to grow under P-deplete conditions. Analysis of sequenced microbial genomes show that glsB is primarily confined to the Rhodobacteraceae family, which includes the ecologically important marine Roseobacter clade that are key players in the marine sulphur and nitrogen cycles. Analysis of the genes involved in glutamine lipid biosynthesis in the Tara ocean metagenome dataset revealed the global occurrence of glsB in marine surface waters and a positive correlation between glsB abundance and N* (a measure of the deviation from the canonical Redfield ratio), suggesting glutamine lipid plays an important role in the adaptation of marine Rhodobacteraceae to P limitation.
Riluzole reduces amyloid beta pathology, improves memory, and restores gene expression changes in a transgenic mouse model of early-onset Alzheimer’s disease
Authors: Okamoto Masahiro , Gray Jason D. , Larson Chloe S. , Kazim Syed Faraz , Soya Hideaki , McEwen Bruce S. , Pereira Ana C. 
Published: August 2018

AbstractAlzheimer’s disease (AD) represents a major healthcare burden with no effective treatment. The glutamate modulator, riluzole, was shown to reverse many AD-related gene expression changes and improve cognition in aged rats. However, riluzole’s effect on amyloid beta (Aβ) pathology, a major histopathological hallmark of AD, remains unclear. 5XFAD transgenic mice, which harbor amyloid β precursor protein (APP) and presenilin mutations and exhibit early Aβ accumulation, were treated with riluzole from 1 to 6 months of age. Riluzole significantly enhanced cognition and reduced Aβ42, Aβ40, Aβ oligomers levels, and Aβ plaque load in 5XFAD mice. RNA-Sequencing showed that riluzole reversed many gene expression changes observed in the hippocampus of 5XFAD mice, predominantly in expression of canonical gene markers for microglia, specifically disease-associated microglia (DAM), as well as neurons and astrocytes. Central to the cognitive improvements observed, riluzole reversed alterations in NMDA receptor subunits gene expression, which are essential for learning and memory. These data demonstrate that riluzole exerts a disease modifying effect in an Aβ mouse model of early-onset familial AD.
Ancient DNA from Chalcolithic Israel reveals the role of population mixture in cultural transformation
Authors: Harney Éadaoin , May Hila , Shalem Dina , Rohland Nadin , Mallick Swapan , Lazaridis Iosif , Sarig Rachel , Stewardson Kristin , Nordenfelt Susanne , Patterson Nick , Hershkovitz Israel , Reich David 
Published: August 2018

AbstractThe material culture of the Late Chalcolithic period in the southern Levant (4500–3900/3800 BCE) is qualitatively distinct from previous and subsequent periods. Here, to test the hypothesis that the advent and decline of this culture was influenced by movements of people, we generated genome-wide ancient DNA from 22 individuals from Peqi’in Cave, Israel. These individuals were part of a homogeneous population that can be modeled as deriving ~57% of its ancestry from groups related to those of the local Levant Neolithic, ~17% from groups related to those of the Iran Chalcolithic, and ~26% from groups related to those of the Anatolian Neolithic. The Peqi’in population also appears to have contributed differently to later Bronze Age groups, one of which we show cannot plausibly have descended from the same population as that of Peqi’in Cave. These results provide an example of how population movements propelled cultural changes in the deep past.
Biomimetic nanoflowers by self-assembly of nanozymes to induce intracellular oxidative damage against hypoxic tumors
Authors: Wang Zhenzhen , Zhang Yan , Ju Enguo , Liu Zhen , Cao Fangfang , Chen Zhaowei , Ren Jinsong , Qu Xiaogang 
Published: August 2018

AbstractReactive oxygen species (ROS)-induced apoptosis is a promising treatment strategy for malignant neoplasms. However, current systems are highly dependent on oxygen status and/or external stimuli to generate ROS, which greatly limit their therapeutic efficacy particularly in hypoxic tumors. Herein, we develop a biomimetic nanoflower based on self-assembly of nanozymes that can catalyze a cascade of intracellular biochemical reactions to produce ROS in both normoxic and hypoxic conditions without any external stimuli. In our formulation, PtCo nanoparticles are firstly synthesized and used to direct the growth of MnO2. By adjusting the ratio of reactants, highly-ordered MnO2@PtCo nanoflowers with excellent catalytic efficiency are obtained, where PtCo behaves as oxidase mimic and MnO2 functions as catalase mimic. In this way, the well-defined MnO2@PtCo nanoflowers not only can relieve hypoxic condition but also induce cell apoptosis significantly through ROS-mediated mechanism, thereby resulting in remarkable and specific inhibition of tumor growth.
Clinical relevance of the 21-gene Recurrence Score® assay in treatment decisions for patients with node-positive breast cancer in the genomic era
Authors: Mamounas Eleftherios P. , Russell Christy A. , Lau Anna , Turner Michelle P. , Albain Kathy S. 
Published: August 2018

AbstractIn contemporary management of early-stage breast cancer, clinical decisions regarding adjuvant systemic therapy are increasingly made after considering both genomic assay results and clinico-pathologic features. Genomic information augments the prognostic information gleaned from clinico-pathologic features by providing risk estimates for distant recurrence and/or breast cancer-specific survival based on individual tumor biology. The 21-gene Oncotype DX Breast Recurrence Score® (RS) assay is validated to be prognostic and predictive of chemotherapy benefit in patients with hormone receptor-positive (HR+), HER2-negative early-stage breast cancer, regardless of nodal status. Because patients frequently are recommended to receive adjuvant chemotherapy based on the perceived poor prognosis related to a positive nodal status, inconsistent use of any prognostic genomic assay in the node-positive (N+) setting likely results in overtreatment of some patients, particularly those with a low genomic risk as defined by the RS test. This comprehensive review of the evidence for the RS assay in patients with N+, HR+, HER2-negative early-stage breast cancer focuses on outcomes of patients with low RS results treated with hormonal therapy alone. Aggregate findings show that the RS assay consistently identifies patients with low genomic risk N+ breast cancer, in whom adjuvant chemotherapy can be avoided without adversely affecting outcomes. This evidence suggests that HR+ patients with limited nodal involvement and low RS results should discuss with their physicians the pros and cons of adjuvant chemotherapy at the time their treatment plans are being decided.
Angiopoietin-like protein 4 (ANGPTL4) is related to gestational weight gain in pregnant women with obesity
Authors: Ortega-Senovilla Henar , van Poppel Mireille N. M. , Desoye Gernot , Herrera Emilio 
Published: August 2018

AbstractAngiopoietin-like protein 4 (ANGPTL4) is a circulating protein involved in the regulation of adipose tissue metabolism. However, its role in obesity and pregnancy is unknown. To evaluate the relationship between gestational weight gain (GWG) and circulating concentrations of ANGPTL4 in pregnant women with overweight and obesity, weight gain and fasting maternal blood samples of thirty-one pregnant women was drawn at 15, 24 and 32 weeks of gestation. ANGPTL4 concentrations continuously rose throughout gestation, whereas VEGF and leptin did not show the same trend. NEFA and glycerol concentrations remained stable during pregnancy. In contrast, total concentrations of saturated, monounsaturated and n-6 fatty acids, but not n-3 fatty acids, increased with pregnancy. In multiple regression analysis, the increase in plasma ANGPTL4 and decrease in linoleic acid concentrations were the most significant predictors of GWG, although only ANGPTL4 was significantly associated with the weight gain from early pregnancy (area under the ROC curve was 0.80 p < 0.01(95% CI 0.61–0.99)). In conclusion, in pregnant women with overweight and obesity, an increase in plasma ANGPTL4 concentrations throughout pregnancy is positively associated with GWG and could be used as an early marker of increased susceptibility to excess gestational weight gain.
Giant magnetoelectric effect at the graphone/ferroelectric interface
Authors: Wang Jie , Zhang Yajun , Sahoo M. P. K. , Shimada Takahiro , Kitamura Takayuki , Ghosez Philippe , Zhang Tong-Yi 
Published: August 2018

AbstractMultiferroic heterostructures combining ferromagnetic and ferroelectric layers are promising for applications in novel spintronic devices, such as memories with electrical writing and magnetic reading, assuming their magnetoelectric coupling (MEC) is strong enough. For conventional magnetic metal/ferroelectric heterostructures, however, the change of interfacial magnetic moment upon reversal of the electric polarization is often very weak. Here, by using first principles calculations, we demonstrate a new pathway towards a strong MEC at the interface between the semi-hydrogenated graphene (also called graphone) and ferroelectric PbTiO3. By reversing the polarization of PbTiO3, the magnetization of graphone can be electrically switched on and off through the change of carbon-oxygen bonding at the interface. Furthermore, a ferroelectric polarization can be preserved down to ultrathin PbTiO3 layers less than one nanometer due to an enhancement of the polarization at the interface. The predicted strong magnetoelectric effect in the ultimately thin graphone/ferroelectric layers opens a new opportunity for the electric control of magnetism in high-density devices.
Zapping 500 faces in less than 100 seconds: Evidence for extremely fast and sustained continuous visual search
Authors: Martin Jacob G. , Davis Charles E. , Riesenhuber Maximilian , Thorpe Simon J. 
Published: August 2018

AbstractA number of studies have shown human subjects’ impressive ability to detect faces in individual images, with saccade reaction times starting as fast as 100 ms after stimulus onset. Here, we report evidence that humans can rapidly and continuously saccade towards single faces embedded in different scenes at rates approaching 6 faces/scenes each second (including blinks and eye movement times). These observations are impressive, given that humans usually make no more than 2 to 5 saccades per second when searching a single scene with eye movements. Surprisingly, attempts to hide the faces by blending them into a large background scene had little effect on targeting rates, saccade reaction times, or targeting accuracy. Upright faces were found more quickly and more accurately than inverted faces; both with and without a cluttered background scene, and over a large range of eccentricities (4°–16°). The fastest subject in our study made continuous saccades to 500 small 3° upright faces at 4° eccentricities in only 96 seconds. The maximum face targeting rate ever achieved by any subject during any sequence of 7 faces during Experiment 3 for the no scene and upright face condition was 6.5 faces targeted/second. Our data provide evidence that the human visual system includes an ultra-rapid and continuous object localization system for upright faces. Furthermore, these observations indicate that continuous paradigms such as the one we have used can push humans to make remarkably fast reaction times that impose strong constraints and challenges on models of how, where, and when visual processing occurs in the human brain.
Polarimetric image recovery method combining histogram stretching for underwater imaging
Authors: Li Xiaobo , Hu Haofeng , Zhao Lin , Wang Hui , Yu Yin , Wu Lan , Liu Tiegen 
Published: August 2018

AbstractThe underwater imaging could be severely degraded by the scattering media because of the backscattered light and signal attenuation, especially in the case of strong scattering for dense turbid medium. In this paper, we propose an improved method for recovering the underwater image combining the histogram stretching and polarimetric recovery in a proper way. In this method, we stretch the histograms of the orthogonal polarization images while maintaining the polarization relation between them, and then, based on the processed orthogonal polarization images, the recovered image with higher quality can be obtained by the traditional polarimetric recovery method. Several groups of experimental results demonstrate that the quality of underwater images can be effectively enhanced by our method, and its performance is better than that of the traditional polarimetric recovery method. In particular, the proposed method is also quite effective in the condition of dense turbid medium.
Cigarette smoke exposure decreases CFLAR expression in the bronchial epithelium, augmenting susceptibility for lung epithelial cell death and DAMP release
Authors: Faiz Alen , Heijink Irene H. , Vermeulen Cornelis J. , Guryev Victor , van den Berge Maarten , Nawijn Martijn C. , Pouwels Simon D. 
Published: August 2018

AbstractCigarette smoking is a major risk factor for the inflammatory disease, chronic obstructive pulmonary disease (COPD). The mechanism by which cigarette smoke (CS) induces chronic lung inflammation is still largely unknown. We hypothesize that immunogenic airway epithelial cell death is involved in the initiation of the inflammatory response. We previously identified CFLAR, the gene encoding the cell death regulator protein c-FLIP, to be associated with CS-induced release of damage-associated molecular patterns (DAMPs). Here, we investigated the effect of CS on expression levels of CFLAR in bronchial biopsies from smokers and non-smokers and CFLAR transcript isoform-expression in a dataset of air-liquid interface-differentiated bronchial epithelial cells. Furthermore, CFLAR was down-regulated by siRNA in lung epithelial A549 cells, followed by investigation of the effects on apoptosis, necrosis and DAMP release. CS exposure significantly decreased CFLAR expression in bronchial epithelial cells. Moreover, we observed a shift in relative abundance of the isoforms c-FLIPS and c-FLIPL transcripts in bronchial biopsies of current smokers compared to non-smokers, consistent with a shift towards necroptosis. In vitro, down-regulation of CFLAR increased apoptosis at baseline as well as CS extract-induced necrosis and DAMP release. In conclusion, CS exposure decreases CFLAR expression, which might increase susceptibility to immunogenic cell death.
Isolation, Structure Elucidation, and Absolute Configuration of Germacrane Isomers from Carpesium divaricatum
Authors: Zhang Tao , Chen Jia-Huan , Si Jin-Guang , Ding Gang , Zhang Qiu-Bo , Zhang Hong-Wu , Jia Hong-Mei , Zou Zhong-Mei 
Published: August 2018

AbstractFive sets of germacrane isomers (1/8/17, 2/7/10/11/13/16/18, 3/4/5/14/20, 6/12/15, and 9/19) with different skeletal types, including seven new ones (1–3, 8–9, and 15–16) were isolated from the whole plant of Carpesium divaricatum. Among them, there are six pairs of stereoisomers (1/8, 2/13, 4/14, 6/12, 7/11 and 10/11). The planar structures and relative configurations of the new compounds were elucidated by detailed spectroscopic analysis. The absolute configurations of 4, 10, 11, and 17 were established by circular dichroism (CD) spectra and X-ray crystallographic analyses, and the stereochemistry of the new compounds 1–3, 8–9, and 15–16 were determined by similar CD spectra with 4, 10, 11, and 17, respectively. The confusion in the literature about subtypes I and II of germacranolides was clarified in this paper. The NMR data of 10–11, and the absolute configurations of the known compounds 4–6, 13–14, and 17–20 were reported for the first time. Compounds 13, 17, and 18 showed cytotoxicity against human cervical (HeLa), colon (LoVo) and stomach cancer (BGC-823) cell lines with IC50 values in the range 4.72–13.68 μM compared with the control cis-platin (7.90–15.34 μM).
Murine Models of Steroid Refractory Graft-versus-Host Disease
Authors: Toubai Tomomi , Rossi Corinne , Tawara Isao , Liu Chen , Zajac Cynthia , Oravecz-Wilson Katherine , Peltier Daniel , Sun Yaping , Fujiwara Hideaki , Wu Shin-Rong , Riwes Mary , Henig Israel , Kim Stephanie , Reddy Pavan 
Published: August 2018

AbstractCorticosteroids are the first line therapy for acute graft-versus-host disease (GVHD). However, the outcome of steroid refractory GVHD (SR-GVHD) is poor due to a lack of effective treatments. The development of therapies for SR-GVHD is limited by an incomplete understanding of its pathophysiology partly because of the absence of clinically relevant animal models of SR-GVHD. Here we addressed the need for a SR-GVHD animal model by developing both MHC matched multiple minor histocompatibility antigens (miHAs) mismatched and MHC mismatched haploidentical murine models of SR-GVHD. We demonstrate that animals can develop SR-GVHD regardless of whether steroids are initiated early or late post allogeneic bone marrow transplantation (allo-BMT). In general, we observed increased GVHD specific histopathological damage of target organs in SR-GVHD animals relative to steroid responsive animals. Interestingly, we found no significant differences in donor T cell characteristics between steroid refractory and responsive animals suggesting that donor T cell independent mechanisms may play more prominent roles in the pathogenesis of SR-GVHD than was considered previously.
JAK/STAT guarantees robust neural stem cell differentiation by shutting off biological noise
Authors: Tanaka Yoshitaro , Yasugi Tetsuo , Nagayama Masaharu , Sato Makoto , Ei Shin-Ichiro 
Published: August 2018

AbstractOrganismal development is precisely regulated by a sequence of gene functions even in the presence of biological noise. However, it is difficult to evaluate the effect of noise in vivo, and the mechanisms by which noise is filtered during development are largely unknown. To identify the noise-canceling mechanism, we used the fly visual system, in which the timing of differentiation of neural stem cells is spatio-temporally ordered. Our mathematical model predicts that JAK/STAT signaling contributes to noise canceling to guarantee the robust progression of the differentiation wave in silico. We further demonstrate that the suppression of JAK/STAT signaling causes stochastic and ectopic neural stem cell differentiation in vivo, suggesting an evolutionarily conserved function of JAK/STAT to regulate the robustness of stem cell differentiation.