bluuebunny/crossref_metadata_2025_split huggingface dataset:
Galvanoplastisches Vervielfältigen einer Münze
Authors: Stock Daniel , Barlou Vasiliki , Schröder Daniel 
Published: August 2019

ZusammenfassungGalvanotechnik und Galvanoplastik sind Paradebeispiele für Methoden der angewandten Elektrochemie, wie sie uns nicht nur in der Archäologie, sondern auch im Alltag begegnen: Beim eloxierten iPod‐Gehäuse, dem verzinkten Weidezaun oder dem Zahnimplantat mit Goldüberzug. Allgemein sind die Prozessabläufe beim Herstellen von galvanischen Schichten sehr komplex. Die Eigenschaften der hergestellten Oberflächenschichten sind durch eine Vielzahl an Parametern steuerbar. Dies setzt viel Geschick und Erfahrung bis zum Herstellen einer verblüffend ähnlichen Kopie voraus – sowohl im heutigen Laborversuch, als auch damals zur Wende vom 19. zum 20. Jahrhundert beim Kopieren der Schätze aus Mykene.
Incidence, patterns of progression, and outcomes of preexisting and newly discovered brain metastases during treatment with anti–PD‐1 in patients with metastatic melanoma
Authors: Schvartsman Gustavo , Ma Junsheng , Bassett Roland L. , Haydu Lauren E. , Amaria Rodabe Navroze , Hwu Patrick , Wong Michael K. , Hwu Wen‐Jen , Diab Adi , Patel Sapna Pradyuman , Davies Michael A. , Hamerschlak Nelson , Tawbi Hussein Abdul‐Hassan , Glitza Oliva Isabella C. 
Published: August 2019

BackgroundMelanoma brain metastases (MBM) occur in up to 50% of patients with metastatic melanoma (MM) and represent a frequent site of systemic treatment failure for targeted therapies. However, to the authors' knowledge, little is known regarding the incidence, patterns of disease progression, and outcomes of MBM in patients treated with anti–PD‐1 immunotherapy.MethodsA total of 320 patients with MM who were treated with anti–PD‐1 at The University of Texas MD Anderson Cancer Center in Houston were reviewed. Analyses were performed to identify factors associated with brain metastasis–free survival and overall survival (OS) using Cox regression models.ResultsThe median age of the patients was 63.3 years. OS from the initiation of anti–PD‐1 therapy was not significantly different between patients without MBM prior to anti–PD‐1 compared with patients with prior MBM (P = .359). Among patients without prior MBM, 21 patients (8.6%) developed MBM during anti–PD‐1 therapy, 12 of whom (4.9%) presented with disease progression in the central nervous system (CNS) only. Developing MBM during or after therapy with anti–PD‐1 (hazard ratio, 4.70; 95% CI, 3.18‐6.93) was associated with shorter OS. Among patients with MBM prior to anti–PD‐1 treatment, 15 (20.0%) progressed in the CNS only and 19 (25.3%) progressed both intracranially and extracranially; at the time of the last data cutoff, 27 patients (36.0%) had not developed disease progression. Radiation necrosis occurred in 11.3% of patients (7 of 62 patients) in the group with a prior MBM who received stereotactic radiosurgery.ConclusionsAnti–PD‐1 therapy may change the natural history of patients with preexisting MBM. However, CNS failure during treatment with anti–PD‐1 is predictive of a worse prognosis compared with extracranial progression. The results of the current study support the activity of anti–PD‐1 in patients with MBM, although routine CNS imaging during therapy is warranted.
A Gaussian error correction multi‐objective positioning model with NSGA‐II
Authors: Wang Penghong , Huang Jianrou , Cui Zhihua , Xie Liping , Chen Jinjun 
Published: August 2019

SummaryDistance vector‐hop (DVHop), as a range‐independent positioning algorithm, is a significant positioning method in wireless sensor networks (WSNs). It is composed of three parts, including connectivity detection, distance estimation, and position estimation. However, this simple positioning method results in a larger positioning error. Therefore, to enhance the positioning precision, this paper investigates the characteristic of error distribution between the estimated and real distance in the DVHop algorithm and reveals that the error is subjecting to the Gaussian distribution, N∼(0,1/3CR). Furthermore, to improve positioning accuracy, we propose a Gaussian error correction multi‐objective positioning model with non‐dominated sorting (NSGA‐II), which named GGAII‐DVHop. Finally, this model is tested on three complex network topologies, and the results demonstrate that it is significantly superior to other four algorithms in both positioning precision and robustness.
Supramolecular Assembly Induced Emission of Thiazole Orange with Sulfobutylether β‐cyclodextrin: A Stimuli‐Responsive Fluorescence Sensor for Tyramine
Authors: Khurana Raman , Barooah Nilotpal , Bhasikuttan Achikanath C. , Mohanty Jyotirmayee 
Published: August 2019

AbstractModulation and control of stimuli responsive features of molecular assemblies in organized assemblies/cavitand macrocycles have received immense attention in many areas. In this study, we have established the formation of a discrete molecular assembly of thiazole orange (TO) dyes at the portals of the sulfobutylether β‐cyclodextrin (SBE7βCD) macrocycle leading to the evolution of a strong and distinct emission band from aggregated TO. The supramolecular assembly promoted portal aggregation of TO in its 1 : 4 (SBE7βCD : TO) composition, characterized by absorption, fluorescence, circular dichroism, ITC and 1H NMR measurements, was probed to be selectively responsive to tyramine among other biogenic amines/neurotransmitters. For the first time, the different extent of emission quenching of SBE7βCD : TO assembly in the presence of biogenic amines/neurotransmitters is translated to achieve a selective on‐off fluorescence sensor for the detection of tyramine against other neurotransmitters with a limit‐of‐detection (LOD) as low as ∼575 nM (79 ppb). The emission features of the assembly with changes in temperature is found to be highly reproducible even after several temperature cycles and is promising to design an optical supramolecular thermometer in the ambient temperature range.
Cytopathology approach to rare salivary gland lesions with oncocytic features
Authors: El Hussein Siba , Khader Samer N. 
Published: August 2019

AbstractSalivary glands located in the head and neck area are known to have different lesions with prominent oncocytic features. Fine needle aspiration is usually the initial approach in the management of these lesions, whether they represent neoplastic or non‐neoplastic processes. Owing to the limited material present upon cytopathologic examination, knowledge of variants and subtypes of various oncocytic lesions that can occur in this area is of major importance to provide the most accurate interpretation to the patients and clinicians. In this article, we selected rare lesions of the salivary glands that may exhibit oncocytic changes, and provided a brief discussion of each one of them, with emphasis on challenges in navigating the differential diagnosis that these cases may pose, from the cytopathology standpoint.
Design, synthesis, and biological activity evaluation of BACE1 inhibitors with antioxidant activity
Authors: Li He‐Min , Yu Shao‐Peng , Fan Tian‐Yuan , Zhong Yue , Gu Ting , Wu Wen‐Yu , Zhao Chao , Chen Zhi , Chen Min , Li Nian‐Guang , Wang Xiao‐Long 
Published: August 2019

AbstractThe proteolytic enzyme β‐secretase (BACE1) plays a central role in the synthesis of the pathogenic β‐amyloid peptides (Aβ) in Alzheimer's disease (AD), antioxidants could attenuate the AD syndrome and prevent the disease progression. In this study, BACE1 inhibitors (D1–D18) with free radical‐scavenging activities were synthesized by molecular hybridization of 2‐aminopyridine with natural antioxidants. The biological activity evaluation showed that D1 had obvious inhibitory activity against BACE1, and strong antioxidant activity in 1,1‐diphenyl‐2‐picrylhydrazyl (DPPH) and 2,2′‐azinobis‐(3‐ethylbenzthiazoline‐6‐sulphonate) (ABTS+•) assay, which could be used as a lead compound for further study.
SupportingSpartina: Interdisciplinary perspective showsSpartinaas a distinct solid genus
Authors: Bortolus Alejandro , Adam Paul , Adams Janine B. , Ainouche Malika L. , Ayres Debra , Bertness Mark D. , Bouma Tjeerd J. , Bruno John F. , Caçador Isabel , Carlton James T. , Castillo Jesus M. , Costa Cesar S. B. , Davy Anthony J. , Deegan Linda , Duarte Bernardo , Figueroa Enrique , Gerwein Joel , Gray Alan J. , Grosholz Edwin D. , Hacker Sally D. , Hughes A. Randall , Mateos‐Naranjo Enrique , Mendelssohn Irving A. , Morris James T. , Muñoz‐Rodríguez Adolfo F. , Nieva Francisco J. J. , Levin Lisa A. , Li Bo , Liu Wenwen , Pennings Steven C. , Pickart Andrea , Redondo‐Gómez Susana , Richardson David M. , Salmon Armel , Schwindt Evangelina , Silliman Brian R. , Sotka Erik E. , Stace Clive , Sytsma Mark , Temmerman Stijn , Turner R. Eugene , Valiela Ivan , Weinstein Michael P. , Weis Judith S. 
Published: August 2019

AbstractIn 2014, a DNA‐based phylogenetic study confirming the paraphyly of the grass subtribeSporobolinaeproposed the creation of a large monophyletic genusSporobolus, including (among others) species previously included in the generaSpartina,Calamovilfa, andSporobolus. Spartinaspecies have contributed substantially (and continue contributing) to our knowledge in multiple disciplines, including ecology, evolutionary biology, molecular biology, biogeography, experimental ecology, biological invasions, environmental management, restoration ecology, history, economics, and sociology. There is no rationale so compelling to subsume the nameSpartinaas a subgenus that could rival the striking, global iconic history and use of the nameSpartinafor over 200 yr. We do not agree with the subjective arguments underlying the proposal to changeSpartinatoSporobolus. We understand the importance of both the objective phylogenetic insights and of the subjective formalized nomenclature and hope that by opening this debate we will encourage positive feedback that will strengthen taxonomic decisions with an interdisciplinary perspective. We consider that the strongly distinct, monophyletic cladeSpartinashould simply and efficiently be treated as the genusSpartina.
Biocatalysis in seawater: Investigating a halotolerant ω‐transaminase capable of converting furfural in a seawater reaction medium
Authors: Kelly Stephen A. , Moody Thomas S. , Gilmore Brendan F. 
Published: August 2019

AbstractThe increasing demand for freshwater and the continued depletion of available resources has led to a deepening global water crisis. Significant water consumption required by many biotechnological processes contributes to both the environmental and economic cost of this problem. Relatively few biocatalytic processes have been developed to utilize the more abundant supply of seawater, with seawater composition and salinity limiting its use with many mesophilic enzymes. We recently reported a salt tolerant ω‐transaminase enzyme, Ad2‐TAm, isolated from the genome of a halophilic bacterium, Halomonas sp. CSM‐2, from a Triassic period salt mine. In this study we aimed to demonstrate its applicability to biocatalytic reactions carried out in a seawater‐based medium. Ad2‐TAm was examined for its ability to aminate the industrially relevant substrate, furfural, in both seawater and freshwater‐based reaction systems. Furfural was aminated with 53.6% conversion in a buffered seawater system, displaying improved function versus freshwater. Ad2‐TAm outperformed the commonly employed commercial ω‐TAms from Chromobacterium violaceum and Vibrio fluvialis, both of which showed decreased conversion in seawater. Given the increasingly precarious availability of global freshwater, such applications of enzymes from halophiles have the ability to reduce demand for freshwater in large‐scale industrial processes, delivering considerable environmental and economic benefits.
The effect of stimulation type, head modeling, and combined EEG and MEG on the source reconstruction of the somatosensory P20/N20 component
Authors: Antonakakis Marios , Schrader Sophie , Wollbrink Andreas , Oostenveld Robert , Rampp Stefan , Haueisen Jens , Wolters Carsten H. 
Published: August 2019

AbstractModeling and experimental parameters influence the Electro‐ (EEG) and Magnetoencephalography (MEG) source analysis of the somatosensory P20/N20 component. In a sensitivity group study, we compare P20/N20 source analysis due to different stimulation type (Electric‐Wrist [EW], Braille‐Tactile [BT], or Pneumato‐Tactile [PT]), measurement modality (combined EEG/MEG – EMEG, EEG, or MEG) and head model (standard or individually skull‐conductivity calibrated including brain anisotropic conductivity). Considerable differences between pairs of stimulation types occurred (EW‐BT: 8.7 ± 3.3 mm/27.1° ± 16.4°, BT‐PT: 9 ± 5 mm/29.9° ± 17.3°, and EW‐PT: 9.8 ± 7.4 mm/15.9° ± 16.5° and 75% strength reduction of BT or PT when compared to EW) regardless of the head model used. EMEG has nearly no localization differences to MEG, but large ones to EEG (16.1 ± 4.9 mm), while source orientation differences are non‐negligible to both EEG (14° ± 3.7°) and MEG (12.5° ± 10.9°). Our calibration results show a considerable inter‐subject variability (3.1–14 mS/m) for skull conductivity. The comparison due to different head model show localization differences smaller for EMEG (EW: 3.4 ± 2.4 mm, BT: 3.7 ± 3.4 mm, and PT: 5.9 ± 6.8 mm) than for EEG (EW: 8.6 ± 8.3 mm, BT: 11.8 ± 6.2 mm, and PT: 10.5 ± 5.3 mm), while source orientation differences for EMEG (EW: 15.4° ± 6.3°, BT: 25.7° ± 15.2° and PT: 14° ± 11.5°) and EEG (EW: 14.6° ± 9.5°, BT: 16.3° ± 11.1° and PT: 12.9° ± 8.9°) are in the same range. Our results show that stimulation type, modality and head modeling all have a non‐negligible influence on the source reconstruction of the P20/N20 component. The complementary information of both modalities in EMEG can be exploited on the basis of detailed and individualized head models.
Nanosized divalent transition metal ion‐prompted macrocyclic complexes: Synthesis, characterization, molecular modeling, and biological studies
Authors: Sangwan Vikas , Singh Dharam Pal 
Published: August 2019

AbstractIn the present research work, four new 14‐membered tetraazamacrocylic complexes of Cobalt(II), Nickel(II), Copper(II) and Zinc(II) with (1E,14E)‐8,8,17,17‐tetramethyl‐2,5,11,14‐tetraazatricyclo[13.3.1.16,10]icosa‐1,5,10,14‐tetraene were synthesized using the template methodology that leads to the formation of a complex of type [MLX2] in which L is a macrocyclic ligand derived from ethylenediamine (ED) and 5,5‐dimethylcyclohexanedione (DCH) and X = Cl−/CH3COO−. Spectroscopic, physical, and analytical characterization of complexes was carried out with the assistance of infra‐red, nuclear magnetic resonance, electron spin resonance, Ultraviolet‐visible, powder X‐Ray diffraction, electron spray ionization ‐ mass spectroscopy (ESI‐MS), thermogravimetric analysis, magnetic susceptibilities, and carbon hydrogen nitrogen analysis. The information regarding the monomeric and nonelectrolytic behavior was elucidated from ESI‐MS and molar conductance values. Powder X‐Ray diffractogram studies point toward the crystalline or amorphous nature of the complexes. All the compounds exhibited the nonelectrolytic nature. Semiempirical calculations were performed using Gaussian 09 software and quantum chemical parameters were determined. Newly designed macrocyclic complexes were examined for their antifungal and antibacterial potency by the Agar well diffusion method. In‐vitro DNA binding studies were carried out in order to understand the extent and nature of binding shown by the complexes with the DNA. In addition to this, in‐silico absorption distribution metabolism excretion toxicity studies were also carried out for the interpretation of drug‐like properties in the newly synthesized complexes.
Crystal structure and magnetic properties of two bimetallic chain compounds
Authors: Liu Xue‐Ying , Wang Yi‐Jun , Jin Kai‐Hang , Tong Yu‐Zhang , Yang Chun , Wang Qing‐Lun 
Published: August 2019

AbstractTwo bimetallic magnetic chain compounds of {[Mn(dpop)(H2O)][Mn(dpop)][Fe[CN]6]•8.5H2O•0.5DMSO}
n (1) and {[Mn(dpop)][Ni[CN]4]}
n (2) (dpop = 2,13‐dimethyl‐3,6,9,12,18‐pentaazabicyclo‐[12.3.1]‐octadeca‐1(18),2,12,14,16‐pentaene) have been synthesized and characterized by single‐crystal X‐ray diffraction and magnetic measurements. Both complexes have cyano‐bridged chain structures, in which complex 1 is a zigzag chain, while complex 2 is nearly a straight line. The magnetic susceptibility results indicate that there is a weak ferromagnetic interaction between manganese (II) ions in complex 1, whereas the interaction is antiferromagnetic in complex 2.
Analysis of the impact of CSF-1 administration in adult rats using a novel Csf1r-mApple reporter gene
Authors: Irvine Katharine M. , Caruso Melanie , Cestari Michelle Ferrari , Davis Gemma M. , Keshvari Sahar , Sehgal Anuj , Pridans Clare , Hume David A. 
Published: August 2019

Abstract
Macrophages are present in large numbers in every tissue in the body where they play critical roles in development and homeostasis. They exhibit remarkable phenotypic and functional diversity, underpinning their adaptation to specialized roles in each tissue niche. CSF1, signaling through the CSF1 receptor, which is restricted to monocyte-macrophage lineage cells in adults, is a critical growth factor controlling macrophage proliferation, differentiation, and many aspects of mature macrophage function. We have generated a macrophage reporter rat, utilizing a construct containing elements of the mouse Csf1r promoter and the highly conserved Fms intronic regulatory element to drive mApple fluorescent protein expression. Csf1r-mApple was robustly expressed in monocyte-macrophage lineage cells in rat bone marrow (BM), peripheral blood, and tissues, with detectable expression in granulocytes and B cells and no evidence of expression in hematopoietic precursors or non-hematopoietic cells. Here, we use the Csf1r-mApple transgene to highlight and dissect the abundance and heterogeneity of rat tissue macrophage populations, and to demonstrate parallel increases in blood monocytes and multiple tissue macrophage populations, including BM, liver, spleen, and lung, in response to CSF1 treatment in vivo. The Csf1r-mApple rat is a novel tool enabling analysis of rat macrophages in situ by direct imaging and providing an additional phenotypic marker to facilitate exploration of rat tissue macrophage phenotypic and functional heterogeneity.
Developing a periodontal disease antibody array for the prediction of severe periodontal disease using machine learning classifiers
Authors: Huang Wei , Wu Jian , Mao Yingqing , Zhu Siwei , Huang Gordon F. , Petritis Brianne , Huang Ruo‐Pan 
Published: August 2019

AbstractBackgroundThe aim of this study was to simultaneously and quantitatively assess the expression levels of 20 periodontal disease‐related proteins in gingival crevicular fluid (GCF) from normal controls (NOR) and severe periodontitis (SP) patients with an antibody array.MethodsAntibodies against 20 periodontal disease‐related proteins were spotted onto a glass slide to create a periodontal disease antibody array (PDD). The array was then incubated with GCF samples collected from 25 NOR and 25 SP patients. Differentially expressed proteins between NOR and SP patients were then used to build receiver operator characteristic (ROC) curves and compare five classification models, including support vector machine, random forest, k nearest neighbor, linear discriminant analysis, and Classification and Regression Trees.ResultsSeven proteins (C‐reactive protein, interleukin [IL]‐1α, interleukin‐1β, interleukin‐8, matrix metalloproteinase‐13, osteoprotegerin, and osteoactivin) were significantly upregulated in SP patients compared with NOR, while receptor activator of nuclear factor‐kappa was significantly downregulated. The highest diagnostic accuracy using a ROC curve was observed for IL‐1β with an area under the curve of 0.984. Five of the proteins (IL‐1β, IL‐8, MMP‐13, osteoprotegerin, and osteoactivin) were identified as important features for classification. Linear discriminant analysis had the highest classification accuracy across the five classification models that were tested.ConclusionThis study highlights the potential of antibody arrays to diagnose periodontal disease.
Holocene palaeoenvironmental reconstruction based on fossil beetle faunas from the Southern Altai region, north‐west China
Authors: ZHANG TIANSHU , ELIAS SCOTT A. 
Published: August 2019

ABSTRACTWe present here the results of the first‐ever Quaternary entomological research in China. The Halashazi Wetland, located in the southern Altai Mountain region in the northernmost part of Xinjiang Province, yielded Holocene insect fossils (mostly beetles) from two peat profiles. In total, 55 Coleoptera taxa were found, including 37 identified species. A new species,Helophorus sinoglacialis, was identified. The fauna is strongly northern Holarctic in character. The interval from 10 424 to 9705 cal aBPwas probably a cold and wet period, and the study site was above the treeline. From 9665 to 9500 cal aBPit was probably warmer and drier, and treeline moved to higher elevations. Following a depositional hiatus, mid‐Holocene (5400–4400 cal aBP) insect assemblages represent cold conditions with the site above the treeline. The exception was a brief warming around 5450 cal aBP, when bark beetle evidence suggests that the treeline moved to a higher elevation. Of the 37 identified beetle species from the Halashazi site, 34 (92%) have modern records in Siberia. The Altai Mountains probably served as a dispersal corridor between the Siberian arctic and alpine regions of northern China. Copyright © 2019 John Wiley & Sons, Ltd.
Interactions between ultraviolet radiation exposure and phosphorus limitation in the marine nitrogen‐fixing cyanobacteria Trichodesmium and Crocosphaera
Authors: Zhu Zhu , Fu Feixue , Qu Pingping , Mak Esther Wing Kwan , Jiang Haibo , Zhang Ruifeng , Zhu Zhuoyi , Gao Kunshan , Hutchins David A. 
Published: August 2019

AbstractIncreased stratification and mixed layer shoaling of the surface ocean resulting from warming can lead to exposure of marine dinitrogen (N2)‐fixing cyanobacteria to higher levels of inhibitory ultraviolet (UV) radiation. These same processes also reduce vertically advected supplies of the potentially limiting nutrient phosphorus (P) to N2 fixers. It is currently unknown how UV inhibition and P limitation interact to affect the biogeochemical cycles of nitrogen and carbon in these biogeochemically critical microbes. We investigated the responses of the important and widespread marine N2‐fixing cyanobacteria Crocosphaera (strain WH0005) and Trichodesmium (strains IMS 101 and GBR) to UV‐A and UV‐B under P‐replete and P‐limited conditions. Growth, N2 fixation, and carbon dioxide (CO2) fixation rates of Trichodesmium IMS 101 and Crocosphaera were negatively affected by UV exposure. This inhibition was greater for Trichodesmium IMS 101 than for Crocosphaera, which fixes N2 only during the night and so avoids direct UV damage. Negative effects of UV on both IMS 101 and Crocosphaera were less in P‐limited cultures than in P‐replete cultures. In contrast, no UV inhibition was observed in GBR, regardless of P availability. UV inhibition was related to different amounts of UV‐absorbing compounds produced by these isolates. Responses to UV radiation and P availability interactions were taxon‐specific, but our results indicated that in general, UV radiation effects on Trichodesmium and Crocosphaera range from negative to neutral. UV inhibition and its interactions with P limitation may thus have a substantial influence on the present day and future nitrogen and carbon cycles of the ocean.