bluuebunny/crossref_metadata_2025_split huggingface dataset:
Взаємозв'язок між дозою тривалого активатора рецепторів еритропоетину та оксидативним стресом у хворих, які лікуються методом гемодіалізу
Authors: Stepanova N. , Korol L. , Novakivskyy V. , Kolesnyk M. 
Published: November 2018

Наукові дані щодо дозозалежного впливу тривалого активатора рецепторів еритропоетину (ТАРЕ) на показники оксидативного стресу та перекисного окислення ліпідів мембран еритроцитів у хворих на хронічну хворобу нирок V, які лікуються гемодіалізом (ГД), є обмеженими.
Метою нашої роботи було оцінити взаємозв’язок між застосованою дозою ТАРЕ та інтенсивністю оксидативних процесів у ГД пацієнтів.
Матеріал та методи. 38 ГД пацієнтів були включені до одномоментного обсерваційного дослідження. Протокол дослідження був схвалений локальною етичною комісією ДУ «Інститут нефрології НАМН України». Усі пацієнти надали письму інформовану згоду на участь у досліджені. Пацієнти були стратифіковані за квартилями (≤ 25% та ≥ 75%) відповідно до середньої дози ТАРЕ і розподілені наступним чином: I групу склали хворі, які отримували ТАРЕ більше 6 місяців у дозі ≤ 50 мкг/міс (n = 20), до II групи увійшли хворі, у яких доза ТАРЕ склала ≥ 125 мкг/міс (n = 18). Поряд із стандартними діагностичними методами досліджували концентрацію малонового діальдегіду у сироватці (МДА) й еритроцитах (MДAe), вміст у крові церулоплазміну (ЦП) та трансферину (ТР). Крім того, визначали загальну пероксидазну активність (ЗПА) у еритроцитах, проникність еритроцитарних мембран (ПЕМ), підрахували відсоток гемолізу.
Результати. У ГД пацієнтів, які лікувались ТАРЕ у дозі ≥ 125 мкг/міс визначено підвищення концентрації ЦР (р = 0,007) та ТР (р = 0,0003), тоді як ЗПА була статистично значуще зниженою порівняно з ІІ групою (р = 0,02). Крім того, У пацієнтів І групи встановлено вищий відсоток гемолізу (р = 0,03) та ПЕМ (р ˂ 0,0001). Використовуючи модель пробіт-регресії, ми визначили дозозалежний вплив ТАРЕ на рівень ПЕМ: χ2 = 21; р ˂ 0,0001.
Висновки. Таким чином, застосування ТАРЕ у дозі понад 125 мкг на місяць покращує антиоксидантний статус ГД хворих, але разом з тим, підвищує гемоліз еритроцитів та ПЕМ. Отримані нами дані потребують подальшого підтвердження.
Функціональний стан нирок у дітей, що перенесли гостре пошкодження нирок, в катамнезі спостереження.
Authors: Lavrenchuk O.V. , Bagdasarova I.V. , Ponomareva M. A. 
Published: November 2018

Гостре пошкодження нирок (ГПН) у дітей має поліетіологічну структуру, особливості перебігу залежні від віку захворювання і високий ризик розвитку хронічної хвороби нирок (ХХН) в катамнезі.
Метою дослідження стало вивчення функціонального стану нирок у дітей, що перенесли ГПН, у віддалених термінах.
Матеріали та методи. Було ретроспективно проаналізовано функціональний стан нирок (швидкість клубкової фільтрації (ШКФ)за Шварцом, рівень паратіреоідного гормону (ПТГ), альбумінурії (АУ), динамічної і статичної реносцинтиграфіі(РСГ)) за даними 60 історій хвороб дітей від 1 до 18 років, що перенесли ГПН протягом 2000-2016 р.р.
Результати. Протягом першого року спостереження у 61,5% хворих зберігалась азотемія,, уповільнення ШКФ та високий рівень АУ. Подальше спостереження за цією групою хворих виявило тенденцію нормалізації рівнів креатиніну, сечовини, ШКФ, але зростання рівнів АУ. В динаміці спостереження від 5 до 15 років, визначено, що у 13,3% пацієнтів ШКФ становила від 90 до 85 мл/мін, а у 36,7% - від 85 до 30 мл/мін. У 46,7% дітей при не змінених показниках креатиніну і ШКФ, відмічено зростання рівню альбумінурії від 45 до 601 мг/добу. За період спостереження, від 15 років і більше, повністю одужало 53,3% дитини, у 31,6% хворих констатована хронічна ниркова недостатність (ХНН), а у 30,0% спостерігалось одужання з дефектом - стійке зниження функції з наявними маркерами пошкодження нирок.
Висновки. Гостре пошкодження нирок частіше зустрічалось серед дітей перших 3 років життя, переважно у хлопчиків. Етіологічним чинником виникнення захворювання був гемолітико-уремічний синдром на фоні гострої кишкової інфекції. Повне одужання документоване у 20,0% реконвалесцентів ГПН, у 30,0% констатовано персистенцію маркерів пошкодження нирки з відновленням функції, а у 18,3% значне, стійке зниження функції нирок. Багатоцільове сцинтиграфічне дослідження з радіофірмпрепаратами різного типу виведення виявило ознаки порушення канальцевих та гломерулярних функцій за 7-8 років до появи лабораторних змін.
Employment Outcomes among Registered Dietitians following Graduation in Manitoba
Authors: Mudryj Adriana , Farquhar Kayla , Spence Kerry , Vagianos Kathy , Suh Miyoung , Riediger Natalie 
Published: November 2018

Purpose: The study objectives were to (i) describe employment outcomes among Registered Dietitians (RDs) who graduated from the University of Manitoba, (ii) test for differences in employment outcomes according to graduation year, and (iii) compare preferred area of practice and geography prior to employment with past and current employment. Methods: Graduates of the Human Nutritional Sciences program (2006–2015) were invited to participate in an online survey. Data on respondent demographics, education, and employment outcomes were collected. Results: Overall, 133 (68%) respondents self-identified as RDs. RDs who had graduated between 2006 and 2011 were significantly more likely to secure employment within 6 months post-graduation compared with RDs that graduated between 2012 and 2015. Geographically, although 56% of RDs did not wish to gain experience in rural/remote communities upon graduating, 44% of these respondents reported working part- or full-time in a rural/remote location at some point during their career. Conclusion: Findings indicate that a substantial number of RDs in Manitoba are employed in a rural or remote location despite acknowledging that it is not a preferred location. Future research is needed to explore the views and experiences of new and established RDs toward rural or remote practice, including preparedness for practice.
The 50 most cited publications in endoscopic third ventriculostomy: a bibliometric analysis
Authors: Zagzoog Nirmeen , Attar Ahmed , Reddy Kesh 
Published: November 2018

OBJECTIVEAlthough endoscopic third ventriculostomy (ETV) for the treatment of hydrocephalus was introduced in 1923, the method was relegated to the sidelines in favor of extracranial techniques. Since the 1990s to the beginning of the current century, however, ETV has undergone a remarkable resurgence to become the first-line treatment for obstructive hydrocephalus, and for some groups, the procedure has been applied for communicating hydrocephalus as well. In the present study, the authors identified the top 50 cited ETV works. These articles represent works of significance that document current practices and provide guidance for future inquiry.METHODSThe top 50 cited articles pertaining to ETV were identified using bibliometric data obtained with the Harzing’s Publish or Perish software search engine. These high-impact works were evaluated for publication properties including year, country of authorship, category, and journal.RESULTSThe top 50 works were cited an average of 141.02 times with a mean of 9.45 citations per year. Articles published in 2005 were the most numerous in the top 50 group. These top articles were most frequently published in the Journal of Neurosurgery: Pediatrics. Most of the articles were clinical studies reporting on patients in the pediatric age group. The country of most authorship was the US, although many other countries were among the top 50 works.CONCLUSIONSThe present report discusses the bibliometric analysis of the top 50 ETV articles. This list may be useful to those interested in the progress and current status of this procedure.
Assessment of costs in open surgery and stereotactic radiosurgery for vestibular schwannomas
Authors: Abou-Al-Shaar Hussam , Azab Mohammed A. , Karsy Michael , Guan Jian , Alzhrani Gmaan , Gozal Yair M. , Jensen Randy L. , Couldwell William T. 
Published: November 2018

OBJECTIVEMicrosurgical resection and radiosurgery remain the most widely used interventions in the treatment of vestibular schwannomas. There is a growing demand for cost-effectiveness analyses to evaluate these two treatment modalities and delineate the factors that drive their total costs. Here, the authors evaluated specific cost drivers for microsurgical and radiosurgical management of vestibular schwannoma by using the Value Driven Outcomes system available at the University of Utah.METHODSThe authors retrospectively reviewed all cases involving microsurgical and radiosurgical treatment of vestibular schwannomas at their institution between November 2011 and September 2017. Patient and tumor characteristics, subcategory costs, and potential cost drivers were analyzed.RESULTSThe authors identified 163 vestibular schwannoma cases, including 116 managed microsurgically and 47 addressed with stereotactic radiosurgery (SRS). There were significant differences between the two groups in age, tumor size, and preoperative Koos grade (p < 0.05), suggesting that indications for treatment were markedly different. Length of stay (LOS) and length of follow-up were also significantly different. Facility costs were the most significant contributor to both microsurgical and SRS groups (58.3% and 99.4%, respectively); however, physician professional fees were not specifically analyzed. As expected, microsurgical treatment resulted in an average 4-fold greater overall cost of treatment than for SRS cases (p < 0.05), and there was a greater variation in costs for open cases as well. Costs remained stable over time for both open resection and SRS. Multivariable analysis showed that LOS (β = 0.7, p = 0.0001), discharge disposition (β = 0.2, p = 0.004), nonserviceable hearing (β = 0.1, p = 0.02), and complications (β = 0.2, p = 0.005) affected cost for open surgery, whereas no specifically examined factor could be identified as driving costs for SRS.CONCLUSIONSThis analysis identified the fact that facility utilization constitutes the majority of total costs for both microsurgery and SRS treatment modalities of vestibular schwannomas. LOS, discharge disposition, nonserviceable hearing, and complications contributed significantly to the total costs for the microsurgical group, whereas none of the factors could be identified as driving total costs for the SRS group. This information may be used to establish policies and protocols to reduce facility costs, with the goal of decreasing the total costs without jeopardizing patient care.
Comparing costs of microsurgical resection and stereotactic radiosurgery for vestibular schwannoma
Authors: Schnurman Zane , Golfinos John G. , Epstein David , Friedmann David R. , Roland J. Thomas , Kondziolka Douglas 
Published: November 2018

OBJECTIVEGiven rising scrutiny of healthcare expenditures, understanding intervention costs is increasingly important. This study aimed to compare and characterize costs for vestibular schwannoma (VS) management with microsurgery and radiosurgery to inform practice decisions and appraise cost reduction strategies.METHODSIn conjunction with medical records, internal hospital financial data were used to evaluate costs. Total cost was divided into index costs (costs from arrival through discharge for initial intervention) and follow-up costs (through 36 months) for 317 patients with unilateral VSs undergoing initial management between June 2011 and December 2015. A retrospective matched cohort based on tumor size with 176 patients (88 undergoing each intervention) was created to objectively compare costs between microsurgery and radiosurgery. The full sample of 203 patients treated with resection and 114 patients who underwent radiosurgery was used to evaluate a broad range of outcomes and identify cost contributors within each intervention group.RESULTSWithin the matched cohort, average index costs were significantly higher for microsurgery (100% by definition, because costs are presented as a percentage of the average index cost for the matched microsurgery group; 95% CI 93–107) compared to radiosurgery (38%, 95% CI 38–39). Microsurgery had higher average follow-up costs (1.6% per month, 95% CI 0.8%–2.4%) compared to radiosurgery (0.5% per month, 95% CI 0.4%–0.7%), largely due to costs incurred in the initial months after resection. A major contributor to total cost and cost variability for both resection and radiosurgery was the need for additional interventions in the follow-up period, which were necessary due to complications or persistent functional deficits. Although tumor size was not associated with increased total costs for radiosurgery, linear regression analysis demonstrated that, for patients who underwent microsurgery, each centimeter increase in tumor maximum diameter resulted in an estimated increase in total cost of 50.2% of the average index cost of microsurgery (95% CI 34.6%–65.7%) (p < 0.001, R2 = 0.17). There were no cost differences associated with the proportion of inpatient days in the ICU or with specific surgical approach for patients who underwent resection.CONCLUSIONSThis study is the largest assessment to date based on internal cost data comparing VS management with microsurgery and radiosurgery. Both index and follow-up costs are significantly higher when tumors were managed with resection compared to radiosurgery. Larger tumors were associated with increased resection costs, highlighting the incremental costs associated with observation as the initial management.
Case-matched comparative analysis of spinal deformity correction in arthrogryposis multiplex congenita versus adolescent idiopathic scoliosis
Authors: Xu Liang , Chen Zhonghui , Qiu Yong , Chen Xi , Li Song , Du Changzhi , Zhou Qingshuang , Sun Xu 
Published: November 2018

OBJECTIVEAs scoliosis in arthrogryposis multiplex congenita (AMC) is unusual and the number of cases reviewed in previous studies is also relatively small, no previous study exists that has directly compared the results of spinal deformity correction between AMC and adolescent idiopathic scoliosis (AIS) patients. The aim of this study was to compare the radiographic and clinical outcomes of surgical correction of spinal deformity associated with AMC versus AIS.METHODSTwenty-four adolescents with AMC were matched with 48 AIS patients in terms of Cobb angle of main curve, curve pattern, sex, age at surgery, Risser grade, and length of follow-up. Patients in both groups underwent posterior-only spinal correction and fusion procedures. The surgical outcomes and complications were analyzed and compared between the 2 groups.RESULTSIn comparison to the AIS group, the AMC group had a significantly longer mean operation time (5.6 vs 4.4 hours, p = 0.002), more blood loss (1620 ± 250 ml vs 840 ± 260 ml, p < 0.001), and more fusion levels (14.1 ± 2.3 levels vs 12.4 ± 2.5 levels, p = 0.007) as well as a lower correction rate (44.3% ± 11.1% vs 70.8% ± 12.4%, p < 0.001) and a higher rate of loss of correction (5.0% ± 3.1% vs 2.1% ± 1.9%, p < 0.001). Nine patients in the AMC group had preoperative pelvic obliquity, which was corrected from a mean of 14.2° ± 8.4° to a mean of 4.3° ± 3.2° (p < 0.001) after the surgery. The thoracic lordosis and sagittal vertical axis were significantly improved in the AMC group. Notably, however, the AMC group was found to have higher rates of screw malpositioning (15.9% vs 9.5%, p = 0.002) and complications (8/24 [33.3%] vs 4/48 [8.3%], p = 0.016) as compared to the AIS group.CONCLUSIONSCorrection of AMC-associated scoliosis tends to require a longer operating time and involve more fusion levels but results in less correction, more blood loss, and more complications, in comparison with AIS. In addition, more attention should be paid to pelvic obliquity and sagittal hyperlordosis in AMC patients.
Rapid cardiac ventricular pacing to facilitate embolization of vein of Galen malformations: technical note
Authors: Hockley Aaron , Tso Michael K. , Almekhlafi Mohammed A. , Lodha Abhay K. , Clegg Robin , Luntley Jeremy , Eesa Muneer , Wong John H. 
Published: November 2018

OBJECTIVEVein of Galen aneurysmal malformations (VGAMs) in infancy have a poor natural history if left untreated. Their high-flow nature can preclude safe and accurate therapeutic vessel occlusion and the risk of inadvertent pulmonary embolism is predominant. The authors describe the technique of rapid cardiac ventricular pacing for inducing transient hypotension to facilitate the controlled embolization of VGAMs.METHODSInitial transjugular venous access was obtained for placing temporary pacing leads for rapid cardiac ventricular pacing immediately prior to embolization. Definitive transarterial embolization procedures for the VGAMs were then performed in the same setting in which liquid embolic agents or coils were used.RESULTSBeginning in 2010, a total of five procedures were performed in three infants. Transvenous rapid cardiac ventricular pacing was successfully achieved to induce systemic transient flow arrest in all but two attempts, and facilitated partial embolization with n-butyl cyanoacrylate (n-BCA) and coils in all procedures. Ventricular fibrillation occurred twice in one patient and was successfully reversed with defibrillation on both occasions. One patient failed to improve and died from refractory heart failure. Two patients stabilized following staged embolization.CONCLUSIONSRapid transvenous cardiac ventricular pacing can be considered to induce transient hypotension and facilitate controlled embolization in challenging high-flow VGAMs.
Endoscope-assisted (with robotic guidance and using a hybrid technique) interhemispheric transcallosal hemispherotomy: a comparative study with open hemispherotomy to evaluate efficacy, complications, and outcome
Authors: Chandra P. Sarat , Subianto Heri , Bajaj Jitin , Girishan Shabari , Doddamani Ramesh , Ramanujam Bhargavi , Chouhan Mahendra Singh , Garg Ajay , Tripathi Madhavi , Bal Chandrasekhar S. , Sarkar Chitra , Dwivedi Rekha , Sapra Savita , Tripathi Manjari 
Published: November 2018

OBJECTIVEEndoscope-assisted hemispherotomy (EH) has emerged as a good alternative option for hemispheric pathologies with drug-resistant epilepsy.METHODSThis was a prospective observational study. Parameters measured included primary outcome measures (frequency, severity of seizures) and secondary outcomes (cognition, behavior, and quality of life). Blood loss, operating time, complications, and hospital stay were also taken into account. A comparison was made between the open hemispherotomy (OH) and endoscopic techniques performed by the senior author.RESULTSOf 59 cases (42 males), 27 underwent OH (8 periinsular, the rest vertical) and 32 received EH. The mean age was 8.65 ± 5.41 years (EH: 8.6 ± 5.3 years; OH: 8.6 ± 5.7 years). Seizure frequency per day was 7 ± 5.9 (EH: 7.3 ± 4.6; OH: 15.0 ± 6.2). Duration of disease (years since first episode) was 3.92 ± 1.24 years (EH: 5.2 ± 4.3; OH: 5.8 ± 4.5 years). Number of antiepileptic drugs per patient was 3.9 ± 1.2 (EH: 4.2 ± 1.2; OH: 3.8 ± 0.98). Values for the foregoing variables are expressed as the mean ± SD. Pathologies included the following: postinfarct encephalomalacia in 19 (EH: 11); Rasmussen’s syndrome in 14 (EH: 7); hemimegalencephaly in 12 (EH: 7); hemispheric cortical dysplasia in 7 (EH: 4); postencephalitis sequelae in 6 (EH: 2); and Sturge-Weber syndrome in 1 (EH: 1). The mean follow-up was 40.16 ± 17.3 months. Thirty-nine of 49 (79.6%) had favorable outcomes (International League Against Epilepsy class I and II): in EH the total was 19/23 (82.6%) and in OH it was 20/26 (76.9%). There was no difference in the primary outcome between EH and OH (p = 0.15). Significant improvement was seen in the behavioral/quality of life performance, but not in IQ scores in both EH and OH (p < 0.01, no intergroup difference). Blood loss (p = 0.02) and hospital stay (p = 0.049) were less in EH.CONCLUSIONSEH was as effective as the open procedure in terms of primary and secondary outcomes. It also resulted in less blood loss and a shorter postoperative hospital stay.
Determinación de la vulnerabilidad sísmica en las edificaciones de la zona urbana del distrito de Jangas, aplicando el sistema de información geográfica
Authors: Tinoco Meyhuay Tito , Colonia Cerna Pedro , Tinoco Gonzales Pedro 
Published: November 2018

<p>El sismo es uno de los peligros naturales que debido a su magnitud e intensidad causa destrucción y muerte, que a lo largo de la historia y aun en nuestros días no se puede predecir con exactitud cuándo, dónde y de qué magnitud se producirá un futuro evento sísmico. Existen ciertos métodos cualitativos y cuantitativos que permiten reducir los riesgos debido a un evento sísmico, como es la prevención y es responsabilidad de nuestras autoridades locales trabajar en la reducción y/o mitigación de los riesgos. Para la determinación de la Vulnerabilidad Sísmica en las edificaciones de la zona urbana del distrito de Jangas, se aplicó el método del Índice de Vulnerabilidad planteado por los estudiosos italianos Benedetti y Petrini, para lo cual se elaboró la cartografía de la zona urbana en el datum WGS84 y mediante el análisis de once parámetros y la aplicación del SIG para la elaboración de mapas temáticos se ha determinado que, el 21,6% de las viviendas se encuentra en la clase A, con una vulnerabilidad baja, el 39,0% en la clase B, con una vulnerabilidad media, el 34,9% en la clase C, con una vulnerabilidad alta y el 4,5% en la clase D, con una vulnerabilidad muy alta. Teniendo en cuenta el índice de vulnerabilidad y una aceleración horizontal del terreno de 0,32 gr., se obtuvo que 112 viviendas (38,4%) sufrirían el colapso total y 180 viviendas (61,6%) seguirían en pie con algún daño estructural. De acuerdo al índice de daño calculado y teniendo en cuenta el precio por metro cuadrado de construcción, si ocurriera un sismo con las características descritas los daños económicos ascenderían a la suma de S/.54´437,440.00.</p>
La inversión pública nacional, regional y local a nivel departamental y su incidencia en la reducción de la pobreza en el Perú, 2008 – 2015
Authors: Manrique Cáceres Jorge , Polonio Toledo Jéssica 
Published: November 2018

<p>El objetivo del estudio fue investigar la incidencia de la inversión pública en sus tres niveles de gobierno (la inversión que realiza directamente el Gobierno Nacional, la inversión de los gobiernos regionales y la inversión de los gobiernos locales) sobre la reducción de la pobreza estructural para el caso peruano a partir de información departamental (2008-2015). Los resultados muestran que la incidencia de cada uno de estos niveles de gobierno sobre la pobreza estructural ha sido diferente, así encontramos que la inversión de los gobiernos locales ha sido la que más ha contribuido a la reducción de la pobreza, seguido por los programas nacionales; sin embargo, la inversión de los gobiernos regionales todavía no logra el resultado esperado y debe optimizarse. Se enfatiza la necesidad de implementar planes de desarrollo coordinado para mejorar la eficacia de la inversión pública. Al mismo tiempo, este trabajo en el aspecto académico, ha permitido emplear el Modelo de Datos de Panel como técnica econométrica de análisis y como mecanismo para suplir escasez de información.</p>
Sur une nouvelle variété d'idocrase de l'Oued el Achek (Maroc)
Authors: Sandréa André Philippe 
Published: November 2018

Il s'agit d'un minéral rose vif, abondant dans un banc de calcaire cipolin, situé au NE du Djebel Izougerz, le long de l'Oued el Achek (Feuille topographique 1/50. 000e. Agelmous, Maroc). Recueilli en juin 1949.
Le minéral est polychroïque en rose et jaune, n moyen = 1.74, peu biréfringent, uniaxe négatif, et présente des zones marginales biaxes positives, très dispersives. (d = 3.45.)
L'analyse chimique donne une composition d'alumino-silicate de calcium de contact calcaire : SiO₂ = 40 % ; CaO = 31 % ; Al₃O₂ = 11 % ; Fe₂O₃ = 5 % ; MgO =4% ; TiO₂, K₂O, Na₂O, H₂O = 8 %.
Les diagrammes de rayons X indiquent une structure étroitement apparentée à l'idocrase.
Il s'agit donc d'une nouvelle variété d'idocrase rose, titanée, non manganésifère, sans bore ni fluor, présentant des aberrations optiques analogues à celles du groupe des Wiluites.