bluuebunny/crossref_metadata_2025_split huggingface dataset:
STUDY OF SOME FLUOREN-9-ONE THIOSEMICARBAZONES: SYNTHESIS, CATALYTIC EFFECTS AND SPECTRAL CHARACTERIZATION
Authors: GLINMA Bienvenu , KPADONOU Bénédicta , AGNIMONHAN Hyacinthe , MEDEGAN Sèdami , KPOVIESSI Salomé , KAPANDA Coco , GBAGUIDI Fernand 
Published: November 2024

Aim and objective: Nowadays, Schiff bases have shown a remarkable importance in medicinal chemistry research. Semicarbazones, thiosemicarbazones and their derivatives are important Schiff base ligands with biological properties. Fluorenones are important organic compounds used in many different fields. Here, we reported the synthesis of fluoren-9-one thiosemicarbazones (F1-F4).
Methods: For their synthesis, we first carried out a theoretical study based on the physical properties (reasonable pharmacokinetics and drug availability) of the compounds using Lipinski's rules. We also varied the reaction conditions using several reagents (HCl, 1N; H2SO4 conc. and GAA) and ethanol in order to optimize reaction yields. Structure of each molecule was characterized by spectrometrical analysis (MS and IR, and especially NMR 1H and 13C).
Results: During the course of the study, we observed an increase in reaction yields in the presence of the less aqueous acids, particularly with GAA, which gave the best yields (89, 77, 91 and 96%) for molecules F1, F2, F3 and F4 respectively.
Conclusion: We noted that compounds presented essential properties to exhibit pharmaceutical activities. They could have a variety of pharmaceutical activities on pathogens resistant to existing treatments.

Peer Review History:
Received 15 July 2024; Reviewed 10 September 2024; Accepted 23 October; Available online 15 November 2024
Academic Editor: Dr. DANIYAN Oluwatoyin Michael, Obafemi Awolowo University, ILE-IFE, Nigeria, toyinpharm@gmail.com
Average Peer review marks at initial stage: 6.0/10
Average Peer review marks at publication stage: 7.0/10
Reviewers:
Prof. Dr. A. Hakan AKTAŞ, Süleyman Demirel University, Faculty of Science and Art, Department of Chemistry, Isparta-Turkey, hakanaktas@sdu.edu.tr
Dr. Wafa Mohamed Al Madhagi, Sana’a University, Yemen, walmadhaji1983@gmail.com
MODULATION OF MITOCHONDRIAL MEDIATED APOPTOSIS BY SOLVENT FRACTIONS OF THE FRUIT EXTRACTS OF SARCOCEPHALUS LATIFOLIUS (SMITH) BRUCE
Authors: Imah-Harry Joan Uchechukwu , Olorunsogo Olufunso Olabode 
Published: November 2024

Background and aims: The mitochondrial membrane permeability transition (mPT) pore is a critical event exploited in situations where apoptosis is dysregulated. Bioactive agents of plant origin induce mitochondrial-mediated apoptosis via the opening of the mitochondrial outer membrane permeabilization (MOMP). The fruit of Sarcocephalus latifolius is used in folklore medicine for the treatment of tumors and cancer. However, this claim has not been scientifically substantiated.
Methods: In this study, we investigated the inductive effect of the crude methanol extract (CMESL) and a chloroform sub fraction (sCFSL) of Sarcocephalus latifolius fruits on mPT, in vivo. Thirty-five male wistar rats (90 ± 10 g) were acclimatized, divided into seven groups, and treated with 1% DMSO (control) and 25, 50, and 100 mg/kgbw of each of the fractions for thirty days. Rats were sacrificed and liver mitochondria were isolated by differential centrifugation. The MOMP, DNA fragmentation, p53, Bax and BCl-2 protein expressions, Cytochrome c release, and caspase – 3 and -9 activities were assayed in liver tissue by standard methods. CMESL and sCFSL induced mPT pore.
Results: The sCFSL induced MOMP maximally at 100 mg/kgbw, inhibited LPO (78%), enhanced mitochondrial ATPase activity (27.96± 0.04 µmole/mg Protein/min) than CMESL (17.58± 0.03 µmole/mg Protein/min) at the same dose. Similarly, sCFSL caused DNA fragmentation; (77.33%), enhanced caspases -3 and -9 activation; increased p53 and Bax expression levels, increased Cytochrome c release, and downregulated BCl-2 protein expression, compared to CMESL.
Conclusion: These findings showed that sCFSL contains bioactive agents that can induce mitochondrial-mediated apoptosis, and therefore a potential target to be explored in the management of tumors and cancer.

Peer Review History:
Received 12 July 2024; Reviewed 19 September 2024; Accepted 24 October; Available online 15 November 2024
Academic Editor: Dr. Iman Muhammad Higazy, National Research Center, Egypt, imane.higazy@hotmail.com
Average Peer review marks at initial stage: 6.5/10
Average Peer review marks at publication stage: 7.5/10
Reviewers:
Dr. Sangeetha Arullappan, Universiti Tunku Abdul Rahman, Malaysia, sangeetha@utar.edu.my
Dr. Nazim Hussain, North East Frontier Technical University, Arunachal pradesh, India, nhussain116@gmail.com
CELLULAR SIGNALING THROUGH THE USE OF GROWTH FACTORS AND MECHANICAL STIMULUS IN NERVE REGENERATION
Authors: Andrew Ezegbe Chekwube , Ezegbe Amarachi Grace , Chidera Anikwe Celestine , Marchi Juliana 
Published: November 2024

The nervous system consists of the autonomous and peripheral. Peripheral nerve injury which occurs as a result of trauma, accident and other associated factors always results in a significant loss of sensory and motor functions in an individual. The injured nerves can be successfully restored although it requires a lot of complex cellular and molecular response in order to rebuild the functional axons. When this is achieved, the damaged nerve can accurately connect with their original targets. The complete recovery of PNI has not been optimized. Exogenous growth factors (GFs) are a new and emerging therapeutic strategy that can be used in nerve regeneration. The mechanism of action of growth factor is based on the ability to activate the downstream targets of various signaling cascades via binding to the individual receptors in order to exert the multiple effects and restore the neuron and tissue regeneration. Although the GFs are associated with short half-life and rapid deactivation in body fluids. The use of nerve conduits has been able to reduce the limitations. The nerve conduits have been good biocompatibility and biofunctionality properties.

Peer Review History:
Received 14 July 2024; Reviewed 18 September 2024; Accepted 23 October; Available online 15 November 2024
Academic Editor: Dr. Muhammad Zahid Iqbal, AIMST University, Malaysia, drmmziqbal@gmail.com
Average Peer review marks at initial stage: 6.5/10
Average Peer review marks at publication stage: 7.5/10
Reviewers:
Dr. Mohamed Salama, Modern University for Technology & Information, Egypt, salama47@yahoo.com
Dr. Mohammad Shaheen Khan, University Malaysia Sabah, Malaysia, shaheenchem@gmail.com
К юбилею профессора О. Б. Кафановой
Authors: Светлана Владимировна Бурмистрова , Юлия Юрьевна Афанасьева 
Published: November 2024

Статья посвящена профессиональной педагогической и научной деятельности доктора филологических наук, профессора Ольги Бодовны Кафановой. Представлены основные направления ее научной работы (компаративистика, русско-французские литературные связи, Жорж Санд, гендерные исследования), дан обзор ее исследований по русской и зарубежной литературе, переводоведению, обозначен ее профессиональный вклад в развитие международного сотрудничества в области науки и образования.
The article is devoted to the professional pedagogical and scientific activity of Doctor of Philology, Professor Olga Bodovna Kafanova. The article presents the main scientific directions of her work. Among them are comparative studies, Russian-French literary connections, George Sand, gender studies. The article gives an overview of her research on Russian and foreign literature and translation studies, outlines her professional contribution to the development of international cooperation in the field of science and education.
Analisis Pengaruh Kinerja Keuangan terhadap Return Saham Studi Kasus pada Industri Manufaktur yang Terdaftar di Bursa Efek Indonesia
Authors: Sirajuddin  , Rusli Muh , Rijal Andi Syamsul 
Published: November 2024

The aim of this research is to analyze the influence of financial performance on stock returns in manufacturing industries listed on the Indonesia Stock Exchange.The analytical method used in this research is a quantitative descriptive approach. With a population of all manufacturing industries registered on the Indonesian stock exchange using porpusive sampling.
The results of this research show that based on the results of data analysis and discussion in the previous chapter, this research resulted in the following conclusions; Most manufacturing industries listed on the Indonesian Stock Exchange produce negative EVA. This indicates that the industry does not create added economic value because the company does not take into account the cost of capital for the invested equity. ROA, ROE, and EVA do not have a significant effect on stock returns in the manufacturing industry listed on the Indonesia Stock Exchange. This happens because it turns out that company profits are one of the indicators for calculating ROA, ROE and EVA are not the only indicators in making stock price decisions. The cost of capital, which is a component of EVA calculations, is greatly influenced by interest rates. Apart from that, there are differences in technical calculations, company size, conditions of the Indonesian money market, the existence of internal factors other than economic fundamentals, interest rates, devaluation, economic growth, government spending and money supply, sales, sales growth, costs, cash dividends, social, political and economic conditions are factors that must be considered in determining stock returns.
Analisis Penerapan Strategi E-Service Quality dalam Upaya Mempertahankan Kepercayaan Nasabah Bank Syariah Indonesia KCP Makassar Veteran
Authors: Yati Nurhayati , Ilham Gani  , Hamid Supriadi 
Published: November 2024

Penelitian ini bertujuan untuk mengetahui dan menganalisis bagaimana penerapan strategi ­service quality maupun e-service quality dalam upaya mempertahankan kepercayaan nasabah Bank Syariah Indonesia KCP Makassar Veteran. Penelitian ini menggunakan metode deskriptif kualitatif, dengan maksud untuk memahami fenomena tentang apa yang dialami oleh subjek penelitian misalnya perilaku, persepsi, motivasi, dan tindakan dengan cara deskriptif. Dengan pendekatan fenomenology dan teknik pengumpulan data yaitu observasi, wawancara dan dokumentasi. Disamping itu, peneliti menggunakan data-data sekunder yang diperoleh dari menelaah buku-buku, jurnal, artikel, dan pendukung lainnya. Data yang diperoleh kemudian diuji keabsahannya menggunakan metode triangulasi sumber. Hasil penelitian ini dapat disimpulkan bahwa, 1) penerapan strategi service quality dalam upaya mempertahankan kepercayaan nasabah Bank Syariah Indonesia KCP Makassar Veteran yaitu dilihat berdasarkan standar pelayanan yang terdiri dari 6 dimensi, yaitu kepatuhan (compliance), jaminan (assurance), keandalan (realibility), bukti nyata atau bukti langsung (tangibles), empati (empathy) dan daya tanggap (responsiveness). 2) penerapan layanan elektronik banking (e-service quality) dalam upaya mempertahankan kepercayaan nasabah Bank Syariah Indonesia KCP Makassar Veteran yaitu melalui beberapa dimensi pelayanan digital yang meliputi Efficiensy (efisiensi), Fullfillment (pemenuhan produk), Sistem Availablity (ketersediaan sistem), Privacy (keamanan), Responsiveness (ketanggapan), Compensation (kompensasi), dan Contact (kontak).
Potensi Antibakteri Ekstrak (Graptophyllum Pictum (L.) Griff) Pada Porphyromonas gingivalis
Authors: Albert  , Ameliya Az-Zahra Syifa 
Published: November 2024

Background: The most prevalent bacteria found in periodontitis are the Gram-negative anaerobic stem bacteria Porphyromonas gingivalis. Periodontitis can potentially affect tooth mobility and tooth loss. Plaque control can be achieved using mechanical tools such as toothbrushes and interdental cleaners, which are reinforced by the use of antibacterial remedies as a chemical approach. Purple leaves contain chemical compounds including alkaloids, flavonoids, tannins, tripenoids, saponins, and glycosides. Objective: To determine the effectiveness of purple leaves as an antibacterial inhibitor against Porphyromonas gingivalis. Methods: The experimental laboratory study with microdilution method, the breeding of Porphyromonas gingivalis ATCC 33277. The test material is purple leaf extract in six, Concentrations: 100%, 50%, 25%, 12.5%, 6.25%, and 3.125%, as well as aquades (negative control) and chlorhexidine 0.2% (positive control). The antibacterial test was carried out by counting the total bacterial colonies obtained using the formula for the average number of bacterial colonies. Results: In testing purple leaf extract against Porphyromonas gingivalis, the minimum inhibitory concentration (MIC) was obtained at a concentration of 3.125% and the minimum bactericidal concentration (MBC) was obtained at a concentration of 50%. Conclusion: Purple leaf extract is effective as an antibacterial against Porphyromonas gingivalis, starting at 50% and 100% concentrations.
Potensi buah zanthoxylum acanthopodium dc. dalam menghambat kanker rongga mulut
Authors: Syafiqa Amelia Dinda , Sandra Ferry , Ihsan Rizal Muhammad 
Published: November 2024

Background(s): Oral cancer is one of the most highly prevalent cancers with high mortality rate. Advanced-stage cancer often treated with chemotherapy. Chemotherapy does not differentiate between killing tumor cells and normal cells, leading to a range of side effects. Identifying effective approaches with minimal side effects for cancer treatment remains a significant priority within the medical field. Objective(s) : This review aimed to investigate potential avenues for future research on oral cancer using Z. acanthopodium Method(s) : References for this article were determined through searches of PubMed, Google Scholar, and official websites of global health organizations. The search terms were “cancer”, “oral cancer”, “anticancer”, “Zanthoxylum acanthopodium”, “apoptosis” from 2014 to 2024. Main finding(s) : Phytochemical compounds found in plants have a significant role in cancer therapies. Z. acanthopodium fruit has been used in anticancer research due to its wide array of bioactive compounds. Previous studies have shown the anticancer properties of Z. acanthopodium DC. against blood and breast cancer cell lines. Research on its anticancer activity against oral cancer has never been reported. Conclusion(s) : Recent findings confirm Z. acanthopodium as a rich source of bioactive compounds with potential anticancer properties. Further research on its anticancer activity against oral cancer should be promoted.
Uji Three Point Bending Kawat Nikel Titanium Dimensi 0,010 x 0,030 Inci yang digunakan sebagai retainer
Authors: Diva Gama Putri Salsabila , Hamonangan Nasution Fajar , Gadih Pratomo Harris 
Published: November 2024

Background: Fixed retainer are a practical retention method because they require minimal cooperation from the patient. Fixed reteiner are made from various types of wire, one of which is nickel titanium. However, when using a fixed retention device, several problems arise, such as fracture of the wire, loss of bond between the surface of the wire and composite, failure of attachment of the composite to the teeth, and unexpected tooth movement. Objective: To determine the shape memory and superelastic properties of nickel titanium wire with dimensions of 0.010 x 0.030 inches used as a retention device after a three point bending test. Method: This research is a laboratory experimental study using 5 samples of nickel-titanium wire measuring 0.010 x 0.030 inches. The wire length is 30 mm. The collected data was then tested using a tested. Results: Nickel titanium wire measuring 0.010 x 0.030 inches with a deflection of 1.5 mm shows a graph with a smaller hysteresis than a deflection of 2 mm with a wider hysteresis. Nickel-titanium wire measuring 0.010 x 0.030 inches with a deflection of 1.5 mm and 2 mm shows that the wire experiences permanent deformation before returning to its initial shape, which could be due to the amount of deflection applied exceeding the tensile yield strength range limit of the wire. Conclusion: The amount of deflection given to the nickeltitanium wire samples is 1,5 mm and 2 mm influences the amount of force released. The deflection of a given wire determines how much force can be generated when the wire is applied.
Hipomania induzida por aripiprazol em uma paciente com depressão resistente ao tratamento
Authors: Monteiro Dennison Carreiro , Oliveira João Cortez de , Medrado Thamires da Silva Sampaio , Cardoso Víctor Câmara Gusmão , Régis Vitor Gama Vieira de Araújo 
Published: November 2024

Introdução: O aripiprazol é classificado como um antipsicótico atípico de terceira geração e amplamente utilizado nos transtornos psicóticos, episódios de mania/hipomania e no transtorno depressivo maior resistente ao tratamento. Exerce sua ação através do agonismo parcial nos receptores dopaminérgicos D2 e no serotoninérgico 5-HT1A, além do antagonismo nos receptores 5-HT2A, sendo a indução de mania/hipomania um evento considerado raro. Apresentação do caso: Este relato descreve o caso de uma mulher de 63 anos, com transtorno depressivo persistente, que apresentou quadro de hipomania logo após iniciar aripiprazol em baixa dose (5 mg em dias alternados), para potencialização antidepressiva. Método: Relato de caso. CAAE: 82055624.7.0000.5192 Parecer N. 7.062.61 Discussão: A prescrição do aripiprazol em doses reduzidas tem efeito predominantemente “estimulante”, podendo desencadear sintomas de hipomania/mania. Constata-se que os sintomas podem iniciar de maneira precoce e que não há indícios de relação entre a quantidade de medicamento prescrito e o momento de início, intensidade ou duração das mudanças de humor. A prevalência real desses eventos pode ser subestimada, frequentemente confundidos com acatisia, dificultando o diagnóstico. Conclusões: Destaca-se a necessidade de cautela e vigilância quanto a eventuais alterações de humor quanto prescritas baixas doses de aripiprazol para pacientes com transtorno depressivo resistente.
One method of optimal control searching in a heterogeneous discrete systems with a delay in the state of processes
Authors: Блинов Александр Олегович , Расина Ирина Викторовна 
Published: November 2024

Рассматривается класс неоднородных дискретных систем (НДС)
с промежуточными критериями, содержащих два уровня. Системы нижнего
уровня включают в себя переменные состояния с запаздыванием. Такие НДС
представлены на практике и получаются в процессе дискретизации
непрерывных систем при решении задач оптимизации итерационными методами.
Для указанного класса предлагается аналог достаточных условий
оптимальности Кротова, на основе которого строится метод улучшения
управления. Предлагаемый метод проиллюстрирован примером.
A heuristic algorithm for one nonlinear optimal control problem
Authors: Гусева Ирина Сергеевна , Расина Ирина Викторовна 
Published: November 2024

Рассматривается задача оптимального управления для одного
из вариантов квазилинейной системы. Для ее решения используется идея
профессора В. И. Гурмана, предложившего сочетать два варианта принципа
расширения. Один из них, традиционный подход Кротова, а второй - метод
штрафных функций. Выбранный класс систем позволяет провести
аналитическое исследование лагранжиана Кротова, что в свою очередь
приводит к формулировке алгоритма. Полученный алгоритм апробирован
на двух иллюстративных примерах, для которых построены минимизирующие
последовательности. Трудоемкость расчетов сопоставима с методами,
основанными на традиционном принципе расширения. Результаты расчетов
проиллюстрированы таблицами и графиками.
Very late intracranial extraparenchymal solitary metastasis of adenoid cystic carcinoma of the parotid gland: A case report and literature review
Authors: Anami Hidenori , Shiwa Tomoko , Nonaka Taku , Nakano Hiroshi , Hashimoto Ryosuke , Yamada Masatoshi , Kobayashi Tomonori 
Published: November 2024

Background:
Adenoid cystic carcinoma (ACC) of the parotid gland often manifests as distant metastasis long after the initial surgery, resulting in a poor long-term prognosis. The most common sites of metastasis are the lungs, liver, and bones. Single intracranial metastasis is very rare.

Case Description:
A 43-year-old woman with a history of surgical removal of ACC 24 years prior presented with Gerstmann syndrome and right hemianopsia. Head magnetic resonance imaging revealed a solitary extra-axial tumor in the left occipital region. The tumor was surgically removed and pathologically diagnosed as a metastasis of cribriform-type ACC. Since she had no other systemic metastasis, she did not receive adjuvant treatment and has remained recurrence-free for 35 months postoperatively.

Conclusion:
Very late intracranial solitary metastasis of ACC is extremely rare. Due to the risk of delayed recurrence in pathologically confirmed cribriform type ACC, long-term follow-up is recommended.
Giant scalp dermatofibrosarcoma protuberans at mid-occipital scalp: A rare case report
Authors: Hakim Muhammad Luqman Nul , Tjahjono Firman Priguna , Faried Ahmad 
Published: November 2024

Background:
Dermatofibrosarcoma protuberans (DFSP) is a rare type of skin cancer that arises in the deeper layers of the skin, most commonly on the trunk and limbs. The presentation of DFSP on the scalp is worth documentation due to its extremely rare occurrence in the literature.

Case Description:
We describe a case of a 41-year-old female presented with a lump on the back of the head with gradual enlargement. It was solitary with a size 19 × 12 × 10 cm with purulent discharge and intermittent pain. A computed tomography-scan showed an isodense mass at mid occipital without intracranial involvement. Tumor extirpation and the free flap were performed collaborated with plastic surgery. The patient was discharged unremarkably on the 7th postoperative day without any neurological deficits.

Conclusion:
Our case is distinct because, after 24 months without any adjuvant therapy and without any recurrence, the patient is still doing well. This is a very rare clinical entity.
Penetrating intraorbital wooden foreign bodies involving the right frontal lobe of the brain: A rare case report
Authors: Wardhana Donny Wisnu , Bal’afif Farhad , Nazwar Tommy Alfandy , Rosyada Amrina , Putro Wahju Sigit Tjahjono , Kholipah Anisa Nur 
Published: November 2024

Background:
Penetrating orbital trauma from a wooden foreign object is rare and challenging to identify, as it cannot be detected with a computed tomography (CT) scan. This report highlights the clinical presentation, diagnosis, and management of such a case.

Case Description:
A 19-year-old female experienced penetrating orbital trauma from a wooden object following a traffic accident. She intermittently visited the hospital with eye swelling and headache, without visible penetrating wounds on the palpebra. The swelling persisted for weeks, accompanied by increasing signs of ocular and cerebral infection. The suspicion of a non-metallic foreign body penetrating the brain was confirmed 3 months after the initial visit, delayed by the hidden entry wound between the eyelid and eyeball and orbital edema mimicking non-penetrating trauma. A multidisciplinary team managed the case. Procedures included debridement, retro-orbital exploration, retro-orbital abscess evacuation, and frontal basal trephination exploration, successfully removing the wooden object that had penetrated the medial orbit, frontal bone, and brain, along with cerebral abscess evacuation. Postoperative CT scans showed complete removal of the foreign object and successful abscess evacuation. The patient showed improvement in ocular symptoms, resolution of headaches, and no wound leakage. She was discharged on the 14th day after completing antibiotic treatment and having the dressing removed.

Conclusion:
This case is notable for its rarity, high risk of misdiagnosis, and potentially fatal consequences if not promptly managed. We emphasize the importance of patient involvement in routine consultations, careful anamnesis, clinical examination, and a multidisciplinary approach for optimal outcomes.