bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association between stroke knowledge, stroke awareness, and preventive behaviors among older people: A cross‐sectional study
Authors: Pothiban Linchong , Srirat Chomphoonut 
Published: June 2019

AbstractIn this cross‐sectional study, we compared preventive behaviors among Thai people aged >60 years of age, with and without stroke risk, in Chiang Mai Province, Thailand, and examined the associations between stroke knowledge and stroke awareness with preventive behaviors in these two groups (n = 422). Participants completed researcher‐developed tools, including the Personal Demographic Questionnaire, the Stroke Knowledge Questionnaire, the Awareness of Stroke Risk and Severity Questionnaire, and the Stroke Preventive Behavior Questionnaire. The findings revealed a significantly higher mean score of preventive behaviors in older people with stroke risk than in those without risk. For people with stroke risk, stroke knowledge did not result in a significant association with stroke‐preventive behaviors, while stroke awareness did. For those without stroke risk, both stroke knowledge and stroke awareness were significantly associated with stroke‐preventive behaviors. Although the stroke‐preventive behaviors of both groups were performed appropriately, it is necessary for people with stroke risk to maintain preventive behaviors, and for health professionals to regularly assess them for stroke symptoms and encourage people to be proactive about stroke‐preventive behaviors.
Critical care outreach: A valuable resource?
Authors: Hyde‐Wyatt Jaime , Garside Joanne 
Published: June 2019

AbstractBackgroundCritical Care Outreach Services (CCOS) were recommended by the Department of Health in the United Kingdom in 2000. Despite being an established service, research studies have not explicitly demonstrated its efficacy.Aim and objectivesTo explore the impact of CCOS from the perspective of hospital ward staff to inform service improvement potential.DesignA pilot formative process evaluation was used to meet the study aims, including the development of a self‐completion questionnaire.MethodsThe exploratory questionnaire was distributed to a purposive sample of clinical staff (health care assistants, nurses, therapists, and doctors) on two medical and two surgical wards to establish the value of CCOS from the perspective of ward staff.ResultsThe questionnaire was distributed to 195 staff members, of who 58 replied (30%). A descriptive analysis of quantitative data and content analysis of free‐text responses demonstrated that staff knew how and when to use the service, that it was highly valued by all members of the multidisciplinary team, and that CCOS were perceived to have diverse responsibilities. Service improvement suggestions included increased staffing and longer hours of operation.ConclusionsDespite the lack of quality research supporting the efficacy of CCOS in previous research studies, the results of this project support the findings of previous evaluations that the value of the service lies in the support offered to ward staff and in the quality of care provided to patients.Relevance to clinical practiceBecause of the size of this evaluation, it was impossible to draw any generalizable conclusions. However, results clearly indicate that value is given to the support that the Critical Care Outreach Service provides to ward staff.
An ultra‐high‐density genetic map provides insights into genome synteny, recombination landscape and taproot skin colour in radish (Raphanus sativus L.)
Authors: Luo Xiaobo , Xu Liang , Wang Yan , Dong Junhui , Chen Yinglong , Tang Mingjia , Fan Lianxue , Zhu Yuelin , Liu Liwang 
Published: June 2019

SummaryHigh‐density genetic map is a valuable tool for exploring novel genomic information, quantitative trait locus (QTL) mapping and gene discovery of economically agronomic traits in plant species. However, high‐resolution genetic map applied to tag QTLs associated with important traits and to investigate genomic features underlying recombination landscape in radish (Raphanus sativus) remains largely unexplored. In this study, an ultra‐high‐density genetic map with 378 738 SNPs covering 1306.8 cM in nine radish linkage groups (LGs) was developed by a whole‐genome sequencing‐based approach. A total of 18 QTLs for 11 horticulture traits were detected. The map‐based cloning data indicated that the R2R3‐MYB transcription factor RsMYB90 was a crucial candidate gene determining the taproot skin colour. Comparative genomics analysis among radish, Brassica rapa and B. oleracea genome revealed several genomic rearrangements existed in the radish genome. The highly uneven distribution of recombination was observed across the nine radish chromosomes. Totally, 504 recombination hot regions (RHRs) were enriched near gene promoters and terminators. The recombination rate in RHRs was positively correlated with the density of SNPs and gene, and GC content, respectively. Functional annotation indicated that genes within RHRs were mainly involved in metabolic process and binding. Three QTLs for three traits were found in the RHRs. The results provide novel insights into the radish genome evolution and recombination landscape, and facilitate the development of effective strategies for molecular breeding by targeting and dissecting important traits in radish.
An epilepsy‐associated glioneuronal tumor with mixed morphology harboring FGFR1 mutation
Authors: Yamada Seiji , Nobusawa Sumihito , Yamazaki Tatsuya , Teranishi Takao , Watanabe Sadayoshi , Murayama Kazuhiro , Ohba Shigeo , Okabe Asako , Sakurai Kouhei , Urano Makoto , Tsukamoto Tetsuya , Yokoo Hideaki , Hirose Yuichi , Abe Masato 
Published: June 2019

Glioneuronal tumor (GNT) is a rare central nervous system neoplasm composed of glial and neuronal components. Making the specific diagnosis of GNT can be challenging due to histopathological and genetical similarities among some GNTs and low‐grade gliomas.We report a case of GNT with rosette‐forming glioneuronal tumor, dysembryoplastic neuroepithelial tumor, and pilocytic astrocytoma‐like morphology harboring FGFR1 mutation. A 16‐year‐old female presented with absence seizures. Magnetic resonance imaging revealed a right temporal lobe mass with multinodular enhancement by gadolinium administration. The tumor was mostly composed of oligodendrocyte‐like cells (OLCs) with variable perinuclear haloes. Abundant Rosenthal fibers and eosinophilic granular bodies were identified. Neither mitotic figures nor areas of necrosis were seen. Focal neurocytic rosette features, involving ring‐like arrays of OLCs around eosinophilic cores, were observed. Direct sequencing showed a missense mutation in FGFR1 K656E, whereas FGFR1 N546K, PIK3CA, and BRAF V600E were intact. KIAA1549‐BRAF fusion was not detected by fluorescence in situ hybridization analysis.
Extracorporeal rewarming from experimental hypothermia: Effects of hydroxyethyl starch versus saline priming on fluid balance and blood flow distribution
Authors: Schanche Torstein , Kondratiev Timofei , Tveita Torkjel 
Published: June 2019

New Findings
What is the central question of this study?
Mortality in accidental hypothermia patients rewarmed by extracorporeal circulation remains high. Knowledge concerning optimal fluid additions for extracorporeal rewarming is lacking, with no apparent consensus. Does colloid versus crystalloid priming have different effects on fluid balance and blood flow distribution during extracorporeal rewarming?

What is the main finding and its importance?
In our rat model of extracorporeal rewarming from hypothermic cardiac arrest, hydroxyethyl starch generates less tissue oedema and increases circulating blood volume and organ blood flow, compared with saline. The composition of fluid additions appears to be important during extracorporeal rewarming from hypothermia.

AbstractRewarming by extracorporeal circulation (ECC) is the recommended treatment for accidental hypothermia patients with cardiac instability. Hypothermia, along with initiation of ECC, introduces major changes in fluid homeostasis and blood flow. Scientific data to recommend best practice use of ECC for rewarming these patients is lacking, and no current guidelines exist concerning the choice of priming fluid for the extracorporeal circuit. The primary aim of this study was to compare the effects of different fluid protocols on fluid balance and blood flow distribution during rewarming from deep hypothermic cardiac arrest. Sixteen anaesthetized rats were cooled to deep hypothermic cardiac arrest and rewarmed by ECC. During cooling, rats were equally randomized into two groups: an extracorporeal circuit primed with saline or primed with hydroxyethyl starch (HES). Calculations of plasma volume (PV), circulating blood volume (CBV), organ blood flow, total tissue water content, global O2 delivery and consumption were made. During and after rewarming, the pump flow rate, mean arterial pressure, PV and CBV were significantly higher in HES‐treated compared with saline‐treated rats. After rewarming, the HES group had significantly increased global O2 delivery and blood flow to the brain and kidneys compared with the saline group. Rats in the saline group demonstrated a significantly higher total tissue water content in the kidneys, skeletal muscle and lung. Compared with crystalloid priming, the use of an iso‐oncotic colloid prime generates less tissue oedema and increases PV, CBV and organ blood flow during ECC rewarming. The composition of fluid additions appears to be an important factor during ECC rewarming from hypothermia.
A Smart Window for Angular Selective Filtering of Direct Solar Radiation
Authors: Zakirullin Rustam S. 
Published: June 2019

Abstract
Thin-film grating coatings are proposed for smart windows to angular selective filtering of solar radiation. The gratings are formed by absorptive, reflective, or scattering parallel strips (made of chromogenic or other materials) alternating with directionally transmissive strips (untreated surface of pure glass) on two surfaces of the window pane(s). The smart window with grating optical filter has angular selective light transmission and partially or completely blocks the direct solar radiation in a preset angular range and transmits the scattered and reflected radiation without using the daylight redistribution devices. The results of numerical simulation and experimental confirmation of optimum slope angle of the strips on the pane(s), their widths, and relative position on two surfaces to minimize the directional light transmission of the window at the preset date and time of day taking into account orientation of the window to the cardinal, the latitude of the building, and the seasonal and daily distribution of the solar radiation intensity are demonstrated.
Field-based investigation of fault architecture: A case study from the Lenghu fold-and-thrust belt, Qaidam Basin, NE Tibetan Plateau
Authors: Pei Yangwen , Paton Douglas A. , Knipe Rob J. , Lickorish W. Henry , Li Anren , Wu Kongyou 
Published: June 2019

AbstractThe fault zone architecture of a thrust fault zone is critical for understanding the strain accommodation and structural evolution in contractional systems. The fault architecture is also important for understanding fluid-flow behavior both along and/or across thrust fault zones and for evaluating potential fault-related compartmentalization. Because mesoscale (1–100 m) structural features are normally beyond seismic resolution, high-resolution outcrop in situ mapping (5–10 cm resolution) was employed to study the deformation features of a thrust fault zone located in the Qaidam Basin, northeastern Tibetan Plateau. The excellent exposure of outcrops enables the detailed investigation of the Lenghu thrust fault zone and its architecture. The Lenghu thrust fault, a seismically resolvable fault with up to ∼800 m of throw, exhibits a large variation of fault architecture and strain distribution along the fault zone. Multiple structural domains with different levels of strain were observed and are associated with the fault throw distribution across the fault. Based on previously proposed models and high-resolution outcrop mapping, an updated fault zone model was constructed to characterize the structural features and evolution of the Lenghu thrust. The possible parameters that impact fault architecture and strain distribution, including fault throw, bed thickness, lithology, and mechanical heterogeneity, were evaluated. Fault throw distributions and linkages control the strain distribution across a thrust fault zone, with local folding processes contributing important elements in Lenghu, especially where more incompetent beds dominate the stratigraphy. Mechanical heterogeneity, induced by different layer stacking patterns, controls the details of the fault architecture in the thrust zone. The variations in bed thicknesses and mechanical property contrasts are likely to control the initial fault dips and fault/fracture density. Large fault throws are associated with wide strain accommodation and damage zones, although the relationship between the development and width of the fault zone and the throw accumulation remains to be assessed. By presenting the high-resolution mapping of fault architecture, this study provides an insight into the subseismic fault zone geometry and strain distributions possible in thrust faults and reviews their application to assessments of fault zone behavior.
Immature neutrophils in young febrile infants
Authors: Ramgopal Sriram , Walker Lorne W , Nowalk Andrew J , Cruz Andrea T , Vitale Melissa A 
Published: June 2019

BackgroundTo describe the diagnostic value of the absolute band count (ABC) and ratio of immature to total neutrophils (I:T) for invasive bacterial infections (IBIs; bacterial meningitis and bacteraemia) among young febrile infants.MethodsWe performed a cross-sectional study in a paediatric emergency department of febrile infants ≤60 days over 12 years to evaluate the accuracy of the ABC and I:T for IBI.ResultsOf 2930 included patients, 75 (2.6%) had IBIs. The area under the curve (AUC; 95% CI) for ABC was 0.69 (0.62 to 0.76) with sensitivity 0.27 (0.17 to 0.38) and specificity 0.94 (0.93 to 0.95) at cutoff ≥1500 cells/µL. The AUC for I:T was 0.65 (0.59 to 0.72) with sensitivity 0.29 (0.19 to 0.41) and specificity 0.88 (0.87 to 0.89) at cutoff ≥0.2. Only the ABC in infants 29–60 days was minimally accurate.ConclusionThe ABC and I:T were generally inaccurate for detecting IBI in febrile infants. Guidelines without these parameters may be better for risk assessment.
Impact of the WHO Framework Convention on Tobacco Control on global cigarette consumption: quasi-experimental evaluations using interrupted time series analysis and in-sample forecast event modelling
Authors: Hoffman Steven J , Poirier Mathieu J P , Rogers Van Katwyk Susan , Baral Prativa , Sritharan Lathika 
Published: June 2019

Abstract

Objective
To evaluate the impact of the WHO Framework Convention on Tobacco Control (FCTC) on global cigarette consumption.

Design
Two quasi-experimental impact evaluations, using interrupted time series analysis (ITS) and in-sample forecast event modelling.

Setting and population
71 countries for which verified national estimates of cigarette consumption from 1970 to 2015 were available, representing over 95% of the world’s cigarette consumption and 85% of the world’s population.

Main outcome measures
The FCTC is an international treaty adopted in 2003 that aims to reduce harmful tobacco consumption and is legally binding on the 181 countries that have ratified it. Main outcomes were annual national estimates of cigarette consumption per adult from 71 countries since 1970, allowing global, regional, and country comparisons of consumption levels and trends before and after 2003, with counterfactual control groups modelled using pre-intervention linear time trends (for ITS) and in-sample forecasts (for event modelling).

Results
No significant change was found in the rate at which global cigarette consumption had been decreasing after the FCTC’s adoption in 2003, using either ITS or event modelling. Results were robust after realigning data to the year FCTC negotiations commenced (1999), or to the year when the FCTC first became legally binding in each country. By contrast to global consumption, high income and European countries showed a decrease in annual consumption by over 1000 cigarettes per adult after 2003, whereas low and middle income and Asian countries showed an increased annual consumption by over 500 cigarettes per adult when compared with a counterfactual event model.

Conclusions
This study finds no evidence to indicate that global progress in reducing cigarette consumption has been accelerated by the FCTC treaty mechanism. This null finding, combined with regional differences, should caution against complacency in the global tobacco control community, motivate greater implementation of proven tobacco control policies, encourage assertive responses to tobacco industry activities, and inform the design of more effective health treaties.
Characteristics and outcomes of physical activity interventions for individuals with mild traumatic brain injury: a scoping review protocol
Authors: Alarie Christophe , Gagnon Isabelle J , Quilico Enrico , Swaine Bonnie 
Published: June 2019

IntroductionTraumatic brain injury (TBI) is a major public health problem, and it is estimated that 85% of TBIs are diagnosed as mild and are commonly referred to as a concussion. In adults, symptoms are expected to resolve within 10–14 days after the injury, but up to 15% of individuals continue to have symptoms beyond this period. Recent clinical recommendations suggest the use of physical activity (PA) as a therapy to manage persisting symptoms. However, the recommendations regarding PA lack clarity about important intervention parameters to help clinicians deliver the intervention. The objectives of this scoping review are thus to identify the characteristics, the measurement tools, the health-related outcomes and the reported effectiveness of PA-based interventions for adults with persisting symptoms of a mild TBI (mTBI).Methods and analysisThis scoping review protocol will follow Arksey and O’Malley’s six-step iterative process enhanced by another study and will be conducted by a team of researchers and clinical experts. Five databases (MEDLINE, CINAHL, PsycINFO, SPORTDiscuss and Embase), as well as Google, will be searched using an extensive search strategy to capture relevant scientific and grey literature. Articles will be selected if they report on an intervention designed to have an impact on health-related outcomes or participation among individuals having sustained an mTBI. A data extraction form based on the Consensus on Exercise Reporting Template and the Template for Intervention Description and Replication checklists will be created. Quantitative and qualitative data will be analysed accordingly, synthesised and collated in tables.Ethics and disseminationThis scoping review generates new knowledge from published and publicly available literature; thus, an ethical approval is unnecessary to conduct this research. Dissemination of the results will involve all team members in activities aimed to facilitate knowledge uptake among TBI rehabilitation clinical experts locally, nationally and internationally.
Use of prescription opioids among patients with rheumatic diseases compared to patients with hypertension in the USA: a retrospective cohort study
Authors: Chen Sarah K , Feldman Candace H , Brill Gregory , Lee Yvonne C , Desai Rishi J , Kim Seoyoung C 
Published: June 2019

ObjectiveLong-term opioid prescribing has increased amid concerns over effectiveness and safety of its use. We examined long-term prescription opioid use among patients with rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), psoriatic arthritis (PsA) and ankylosing spondylitis (AS), compared with patients with hypertension (HTN).MethodsWe used Truven MarketScan, a US commercial claims database (2003–2014) and identified RA, SLE, PsA and AS cohorts, each matched by age and sex to patients with HTN. We compared long-term opioid prescription use during 1 year of follow-up and used multivariable Poisson regression model to estimate the relative risk (RR) of receiving opioid prescriptions based on underlying disease cohort.ResultsWe identified 181 710 RA (mean age 55.3±13.1, 77% female), 45 834 SLE (47.1±13.1, 91% female), 30 307 PsA (49.7±11.5, 51% female), 7686 AS (44.6±12.0, 39% female) and parallel numbers of age-matched and sex-matched patients with HTN. The proportion of patients receiving long-term opioid prescriptions, and other measures of opioid prescriptions were higher among rheumatic disease cohorts and highest in patients with AS. AS was associated with the highest RR of receiving long-term opioid prescriptions (RR 2.73, 95% CI 2.60 to 2.87) versus HTN, while RRs were 2.21 (2.16 to 2.25) for RA, 1.94 (1.87 to 2.00) for PsA and 1.82 (1.77 to 1.88) for SLE.ConclusionsPatients with rheumatic disease have higher rates of long-term opioid prescriptions, and patients with AS have the highest risk of receiving opioid prescriptions versus patients with HTN. Further studies investigating the effectiveness of disease-targeted treatments on decreasing opioid use in these four rheumatic diseases may provide strategies for reducing prescription opioids.
Special scenarios in the management of central nervous system aspergillosis: a case series and review of literature
Authors: Ray Sucharita , Balaini Neeraj , Chakravarty Kamalesh , Pattanayak Shivnarayan , Goel Abeer , Takkar Aastha , Lal Vivek 
Published: June 2019

AbstractAspergillus is a rare but important opportunistic pathogen to invade the central nervous system (CNS). It is a significant pathogen of not only immunocompromised but also immunocompetent patients. Its manifestations are pleiotropic, reflecting multiple mechanisms of pathogenesis and host interactions. Despite significant advances in diagnostic methods and therapeutic options, the mortality remains high. Several advances have been made in medications and surgical management, yet, current treatment practices lack uniformity. Patient woes are further heightened by the high costs of treatment and prolonged duration of therapy. In view of the challenging aspects of this disease, we present a short review of four challenging cases touching on the varied aspects of management of CNS aspergillosis covering pathogenesis, diagnostic pitfalls, surgical and medical options and evidence-based guidelines for the management of the same.