bluuebunny/crossref_metadata_2025_split huggingface dataset:
Genetic and environmental determinants of stressful life events and their overlap with depression and neuroticism
Authors: Clarke Toni-Kim , Zeng Yanni , Navrady Lauren , Xia Charley , Haley Chris , Campbell Archie , Navarro Pau , Amador Carmen , Adams Mark J. , Howard David M. , Soler Aleix , Hayward Caroline , Thomson Pippa A. , Smith Blair H. , Padmanabhan Sandosh , Hocking Lynne J. , Hall Lynsey S. , Porteous David J. ,   Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, Deary Ian J. , McIntosh Andrew M. 
Published: February 2018

Background: Stressful life events (SLEs) and neuroticism are risk factors for major depressive disorder (MDD). However, SLEs and neuroticism are heritable and genetic risk for SLEs is correlated with risk for MDD. We sought to investigate the genetic and environmental contributions to SLEs in a family-based sample, and quantify genetic overlap with MDD and neuroticism. Methods: A subset of Generation Scotland: the Scottish Family Health Study (GS), consisting of 9618 individuals with information on MDD, past 6 month SLEs, neuroticism and genome-wide genotype data was used in the present study. We estimated the heritability of SLEs using GCTA software. The environmental contribution to SLEs was assessed by modelling familial, couple and sibling components. Using polygenic risk scores (PRS) and LD score regression (LDSC) we analysed the genetic overlap between MDD, neuroticism and SLEs. Results: Past 6-month life events were positively correlated with lifetime MDD status (β=0.21, r2=1.1%, p=2.5 x 10-25) and neuroticism (β =0.13, r2=1.9%, p=1.04 x 10-37) at the phenotypic level. Common SNPs explained 8% of the phenotypic variance in personal life events (those directly affecting the individual) (S.E.=0.03, p= 9 x 10-4). A significant effect of couple environment was detected accounting for 13% (S.E.=0.03, p=0.016) of the phenotypic variation in SLEs. PRS analyses found that reporting more SLEs was associated with a higher polygenic risk for MDD (β =0.05, r2=0.3%, p=3 x 10-5), but not a higher polygenic risk for neuroticism. LDSC showed a significant genetic correlation between SLEs and both MDD (rG=0.33, S.E.=0.08 ) and neuroticism (rG=0.15, S.E.=0.07). Conclusions: These findings suggest that SLEs should not be regarded solely as environmental risk factors for MDD as they are partially heritable and this heritability is shared with risk for MDD and neuroticism. Further work is needed to determine the causal direction and source of these associations.
Aeromedical Battlefield Evacuation Under Endogenous Uncertainty in Casualty Delivery Times
Authors: Lejeune Miguel A. , Margot Francois 
Published: February 2018

We propose a new medical evacuation (MEDEVAC) model with endogenous uncertainty in the casualty delivery times. The goal is to provide timely evacuation and medical treatment to injured soldiers. The model enforces the “Golden Hour” evacuation doctrine, attempts to maximize the expected number of severely injured soldiers evacuated within one hour without delay, and represents the availability of air ambulances as an endogenous source of uncertainty. The MEDEVAC model is a mixed-integer nonlinear programming problem whose continuous relaxation is in general nonconvex and for which we develop an algorithmic method articulated around (i) new bounding techniques obtained through the solution of restriction and relaxation problems and (ii) a spatial branch-and-bound algorithm solving conic mixed-integer programs at each node. The computational study, based on data from Operation Enduring Freedom, reveals that the bounding problems can be quickly solved regardless of problem size, the bounds are tight, and the spatial branch-and-bound dominates the CPLEX and BARON solvers in terms of computational time and robustness. Compared to the MEDEVAC myopic policy, our approach increases the number of casualties treated timely and can contribute to reducing the number of deaths on the battlefield. The benefits increase as the MEDEVAC resources become tighter and the combats intensify. The model can be used at the strategic level to design an efficient MEDEVAC system and at the tactical level for intelligent tasking and dispatching. Data are available at https://doi.org/10.1287/mnsc.2017.2894 . This paper was accepted by Yinyu Ye, optimization.
Simultaneous Preferences for Hedging and Doubling Down: Focal Prospects, Background Positions, and Nonconsequentialist Conceptualizations of Uncertainty
Authors: Markle Alex B. , Rottenstreich Yuval 
Published: February 2018

Most theories of decision making are consequentialist. They presume that people evaluate prospects on the basis of potential outcomes. However, people may often conceptualize prospects in part nonconsequentially. Consider someone evaluating a new, “focal” prospect given an unresolved “background” position to which that person is already exposed. If the two are positively correlated, the individual may conceptualize the focal prospect as a bet “with” the individual’s background position; if they are negatively correlated, the individual may conceptualize the focal prospect as a bet “against” the individual’s background position. Because people like to be consistent, this nonconsequentialist conceptualization may induce a taste for betting “with” the background position. Such bets constitute risk-seeking doubling down, not risk-averse hedging. Indeed, we observe that relative to corresponding background-less choices, participants with unresolved background positions are relatively risk-seeking, favoring positively rather than negatively correlated focal prospects. They also sometimes show a simultaneous taste for both doubling down and hedging. Data are available at https://doi.org/10.1287/mnsc.2017.2918 . This paper was accepted by Manel Baucells, decision analysis.
Racial Plagiarism and Fashion
Authors: Pham Minh-Ha T. 
Published: February 2018

Abstract
This article attempts to chart a path out of the stultifying binary oppositions of “cultural appropriation” and “cultural appreciation” with regard to fashion and beauty forms and practices. “Racial plagiarism,” this essay argues, is a more precise analytic framework for understanding and critiquing the kinds of copying that happen in fashion and beauty contexts than either of the previous terms because it achieves a number of things: (1) it attends to the non-illegal but not unproblematic status of this kind of unauthorized copying; (2) it explicitly connects “racial plagiarism” with other forms of racial and economic exclusions that are also not illegal but not unproblematic; and (3) it demonstrates how non-legal constructions of authorship and copying produce racialized understandings of creativity and criminality.
Diseño y aplicación de un cuestionario sobre la práctica docente del profesorado de matemáticas en ingeniería y ciencias
Authors: Aguiar Barrera Martha Elena , Gutiérrez Pulido Humberto , Gutiérrez González Porfirio 
Published: February 2018

Se describe el diseño, construcción y validación de un cuestionario para caracterizar la práctica docente del profesorado de matemáticas en un centro universitario de ingeniería y ciencias. El instrumento considera cinco dimensiones: ética, pedagógica, científica, humanística y tecnológica. Para el diseño se hizo la delimitación conceptual del cuestionario y sus dimensiones, y se generó una lista de potenciales ítems, que fueron evaluados por expertos. El cuestionario preliminar resultante se aplicó a una muestra piloto, y a partir de esto se generó la versión final. Este tiene dos componentes que son aplicados en forma simultánea, en uno el profesor opina sobre aspectos de la docencia y en otro autoevalúa su propia práctica. Para validar el cuestionario, se aplicó a los docentes del Departamento de Matemáticas en un campus de la Universidad de Guadalajara (México). Los resultados se estudiaron con el análisis de factores (AF), que reveló consistencia interna en los dos componentes del cuestionario, puesto que todas sus dimensiones pudieron asociarse a los factores que resultaron del AF. En el mismo sentido de tal consistencia, se obtuvo que los valores del coeficiente alfa de Cronbach fueron mayores a 0,85. También se usó el AF para orientar la aplicación de tablas de contingencia y la comparación de medias, y se identificaron algunas diferencias significativas de género en la práctica educativa de la población encuestada; como por ejemplo, el que las profesoras fueron más optimistas en cuanto a la práctica de valores como honradez, solidaridad, amor, prudencia, responsabilidad, respeto, integridad y tolerancia; así como la importancia que ellas le dan a cumplir metas profesionales.
Leunca (Solanum nigrum L.) Herbs Ethanolic Extract Increase Cytotoxic Activity of Cisplatin on Hela Cervical Cancer Cells
Authors: Istiaji Raditya Prima , Fitria Maya , Larasati Larasati , Tjondro Fortunella , Maruti Astrid Ayu , Setyowati Erna Prawita , Meiyanto Edy 
Published: February 2018

Cervical cancer is one of leading causes of cancer death in women in the developing countries. The use of cisplatin as chemotherapy agent in cervical cancer is known to cause side effects and also resistance for long-term uses. One of the strategies to prevent cervical cancer based on combination agents is being developed. Leunca (Solanum nigrum L.) has been revealed to inhibit growth of human cancer cells. Therefore, it can be used in combination with cisplatin to reduce those side effects and prevent the occurrence of cell resistance. Ethanolic extract of Leunca Herb (ELH) and cisplatin were tested their cytotoxic effect on HeLa cervical cancer cell by using MTT assay to determine IC50 value. The combinationss of cisplatin-ELH were tested to determine the combination index (CI value). The IC50 of ELH and cisplatin on HeLa cells were 227 µg/mL and 17 µM. rRespectively. Tthe study of combination resulted that almost all the index combinations were <0,9 showed the effect of synergism combination. The Ooptimum concentration of combination was 1/8 IC50 cisplatin–1/8 IC50 ELH. The results indicated that ELH had a potency to be combination agent to enhance the activity of cisplatin on HeLa cervical cancer cells. Therefore, further study on its molecular mechanism needs to be explored. Key words: Leunca (Solanum nigrum L.), cisplatin, cytotoxic, combination agent, HeLa cells
Secretion of Indoleamine 2,3-Dioxygenase, an Immunomodulatory Substance, by Adipose-Derived Mesenchymal Stem Cell
Authors: Laksmitawati Dian Ratih , Sardjono Caroline Tan , Pawitan Jeanne A. , Sadikin Mohammad , Sandra Ferry 
Published: February 2018

Lipoaspirate, a wasted by product from liposuction procedure recently has been shown to contain abundant adipose-derived-mesenchymal stem cells (MSCs). Mesenchymal stem cells (MSCs) have been studied in many research areas to regenerate many cell lineages. In addition, MSCs have immunomodulatory effect. This capability has been utilized in several clinical studies in hematopoetic stem cell and organ transplantation as a strategy to reduce the risk of Graft versus Host Disease (GvHD). It has been reported that the ‘stimulated’ MSC is able to secrete substances to suppress tissue rejection. One of the substances was known to be indoleamine 2,3-dioxygenase (IDO). A previous study has characterized the secretion of IDO by bone marrow-derived MSCs stimulated by an inflammatory mediator interferon gamma (IFN-γ). IDO has been detected using Western blot analysis and by High Performance Liquid Chromatography (HPLC) assay. The aim of this study was to detect the presence of IDO in AD-MSCs culture with and without INFγ stimulation. Our study showed that AD-MSC stimulated with IFN-γ significantly secreted high level of IDO as detected by Enzyme-Linked Immuno Sorbent Assay (ELISA). Despite its property as a proinflammatory mediator, IFN-γ has shown to be able to induce IDO secretion in MSC culture which suggests the immuno modulatory effect of MSC. This study clearly demonstrates the potential application of adipose-derived MSC in the immunomodulatory strategy for allogenic transplantation. Keyword : mesenchymal stem cell, indoleamine 2,3-dioxygenase, IFN-γ
Synergistic Effect of Cinnamon Essential Oil (Cinnamomum burmannii) and Doxorubicin on T47D Cells Correlated with Apoptosis Induction
Authors: Anjarsari Etyk Yunita , Kristina Nita , Larasati Yonika Arum , Putri Dyaningtyas Dewi Pamungkas , Meiyanto Edy 
Published: February 2018

Cinnamon (Cinnamomum burmannii) shows anticancer activity in several types of cancer cells. The aim of this study is to observe the cytotoxic activity of cinnamon essential oil (CEO) solely and its combination with doxorubicin, also the ability of the combination to induce apoptosis on T47D breast cancer cells. The CEO was prepared through distillation of dry cinnamon bark. Cytotoxic assay was performed by using MTT assay and apoptosis determination was done by using double staining with ethidium bromide and acridine orange. The result showed that CEO exhibited cytotoxic effect on T47D cells with IC50 values of 75 µg/ml. Moreover, CEO showed synergist effect with doxorubicin. The lowest combination index (CI) with CI values of 0,37 was obtained by combination of doxorubicin-CEO 37,5 µg/ml-1,25 µM. Treatment with CEO solely and its combination with doxorubicin showed apoptosis induction on T47D cells. The results of this study indicate the potency of CEO to be developed as co-chemotherapeutic agent of doxorubicin on breast cancer. Keywords: cinnamon essential oil, doxorubicin, T47D cells, combination cytotoxic
Evaluation of Anti-angiogenic Activity of Centella asiatica Water Extract on Chick Embryo Chorioallantoic Membrane Induced by bFGF
Authors: Hamid Iwan Sahrial , Widjaja Ngakan Made Rai 
Published: February 2018

Angiogenesis is a physiological process that involves the formation of new blood vessels. In the cancer growth process, angiogenesis acts by supplying nutrition and oxygen for the cancer cells, carries metabolic waste and biological end product of cancer cells. Therefore the spread of cancer cells to the surrounding cells and tissues is accelerated. The occurrence of angiogenesis shows a change in cancer cell status, from dormant to malignant. Cancer cells induce the formation of angiogenesis through the secretion of various growth factors such as Vascular Endothelial Growth Factor (VEGF) and basic Fibroblast Growth Factor (bFGF).Currently many people turn into treatment using natural materials. One of the natural materials used for cancer therapy is pegagan (Centella asiatica). In this research 25 embryonated chicken eggs (ECE) were divided into five treatment groups. Treatment group I as the control received 60 ng bFGF, treatment group II received neither bFGF nor pegagan leaves (Centella asiatica) water extract, and treatment groups III-V received 60 ng bFGF and C. asiatica leaves water extract of 75, 90 and 110 µg. Nine days old ESE were inoculated with bFGF and extract at the same time and then were incubated at 380C for three days to allow the formation of blood vessels in embryonated chicken egg chorioallantoic membrane. Observations were performed microscopically and macroscopically by counting the new blood vessels formed around paper disc. Analysis on VEGF expression were conducted to define the role of angiogenesis growth factor.Research results showed a significant difference of treatment with Centella asiatica water extract on the number of new blood vessels formed. Centella asiatica water extract at the dose of 110 µg was the highest in inhibiting the formation of new blood vessels. Centella asiatica water extract also inhibited the expression of VEGF.Keywords : Centella asiatica, antiangiogenic, Corio Allantois Membran, VEGF
Ethanolic Extract of Secang Heartwood (Caesalpinia sappan L.) Increases Bone Density in Ovariectomized Rats
Authors: Shabrina Bani Adlina , Kristiani Nita , Irnanda Khairunisa , Lumakso Fajar Aji , Jenie Riris Istighfari 
Published: February 2018

Osteoporosis has become a major public health concern, due to its rising incidence every year. Osteoporosis mostly occurs in women at menopause, especially in Asia. Secang (Caesalpinia sappan L.) heartwood contains brazilin and brazilein which are known to suppress expression of NF-ĸB, an osteoclastogenesis protein playing an important role in osteoporosis. Thus, the aim of this research is to investigate the inhibition of osteoporosis by ethanolic extract of secang (Caesalpinia sappan L.) (EES) in ovariectomized (OVX) rats. Thirty female Sprague Dawley rats were divided into five groups treated for 20 days: group I were OVX and treated with 1000 mg/kgBW EES; group II were OVX and treated with 500 mg/kgBW EES; group III were OVX and treated with CMC-Na; group IV were shame OVX baseline; and group V were non-OVX-baseline. Bone density was examined by using X-Ray rontgen and was strengthen by qualitative data of Giemsa staining. Moreover, total number of osteoclasts in bone slide was observed by TRAP expression using double staining immunohistochemistry with hematoxylin eosin (HE) – TRAP. Treatment of 500 mg/kgBW EES in ovariectomized rats showed the highest bone density of 0.60 gr/cm3 and the lowest number of osteoclasts was 4.66 osteoclasts per field of view. These results showed that EES is potent to be developed as an antiosteoporosis agent. Further study on its dose adjustment and molecular mechanism needs to be conducted.Keywords: Caesalpinia sappan L., osteoporosis, RANK, bone density
TÜKETİMİN PARANORMALİ: GÖSTERİŞÇİ TÜKETİM VE PARANORMAL İNANÇ İLİŞKİSİ
Authors: Tosun Nurhan , Karşu Cesur Damla 
Published: February 2018

Gösterişçi tüketim genel olarak bireyin
kendisini alt sınıflardan ayırmak ve ait olmak istediği üst sınıfa yaklaştırmak
amacıyla gerçekleştirdiği tüketim türünü ifade eder. Diğer bir deyişle,
gösterişçi tüketimde bireyin üst sınıfın tüketim kalıplarını taklit etmesi söz
konusudur. Bu çerçevede kişiyi bir anda varlıklı, başarılı, güçlü, seçkin veya
zevk sahibi bir bireye dönüştürme gibi birtakım gizsel güçlerin tüketim nesnelerine
atfedilmiş olduğu görülür. Benzer şekilde göstergeyi ele geçirerek, göstergenin
kimi zaman doğrudan kimi zaman ise rastlantısal olarak temsil ettiği güce de sahip
olunabileceği fikri paranormal inançlar bağlamında ele alınabilir. Bu çalışma ise, gösterişçi tüketim nesnelerine
atfedilen söz konusu güce yönelik inanç ile paranormal inançlar arasında kökensel
olarak bir benzerlik kurar. Buradan yola çıkan araştırma gösterişçi tüketim
eğilimi ile paranormal inanç eğilimi arasında bir ilişkinin olup olmadığını
nicel olarak sorgular. Bu doğrultuda Marmara Üniversitesi İletişim Fakültesi’nde
313 katılımcı ile gerçekleşen araştırma, gösterişçi tüketim eğilimi ile
paranormal inanç eğilimi arasında pozitif yönlü bir ilişki tespit eder
Non-hyperbolic P-Invariant Closed Characteristics on Partially Symmetric Compact Convex Hypersurfaces
Authors: Liu Hui , Zhu Gaosheng 
Published: February 2018

Abstract
Let

n
≥
2

{n\geq 2}

be an integer,

P
=

diag
⁢

(

-

I

n
-
κ

,

I
κ

,

-

I

n
-
κ

,

I
κ

)

{P=\mathrm{diag}(-I_{n-\kappa},I_{\kappa},-I_{n-\kappa},I_{\kappa})}

for some integer

κ
∈

[
0
,
n
]

{\kappa\in[0,n]}

, and let

Σ
⊂

ℝ

2
⁢
n

{\Sigma\subset{\mathbb{R}}^{2n}}

be a partially symmetric compact convex hypersurface, i.e.,

x
∈
Σ

{x\in\Sigma}

implies

P
⁢
x

∈
Σ

{Px\in\Sigma}

, and

(
r
,
R
)

{(r,R)}

-pinched. In this paper, we prove that when

R
/
r

<

5
/
3

{{R/r}<\sqrt{5/3}}

and

0
≤
κ
≤

[

n
-
1

2

]

{0\leq\kappa\leq[\frac{n-1}{2}]}

, there exist at least

E
⁢

(

n
-

2
⁢
κ

-
1

2

)

+

E
⁢

(

n
-

2
⁢
κ

-
1

3

)

{E(\frac{n-2\kappa-1}{2})+E(\frac{n-2\kappa-1}{3})}

non-hyperbolic P-invariant closed characteristics on Σ. In addition, when

R
/
r

<

3
/
2

{{R/r}<\sqrt{3/2}}

,

[

n
+
1

2

]

≤
κ
≤
n

{[\frac{n+1}{2}]\leq\kappa\leq n}

and Σ carries exactly n
P-invariant closed characteristics, then there exist at least

2
⁢
E
⁢

(

2
⁢
κ

-
n
-
1

4

)

+

E
⁢

(

n
-
κ
-
1

3

)

{2E(\frac{2\kappa-n-1}{4})+E(\frac{n-\kappa-1}{3})}

non-hyperbolic P-invariant closed characteristics on Σ, where the function

E
⁢

(
a
)

{E(a)}

is defined as

E
⁢

(
a
)

=

min
⁡

{

k
∈
ℤ

∣

k
≥
a

}

{E(a)=\min{\{k\in{\mathbb{Z}}\mid k\geq a\}}}

for any

a
∈
ℝ

{a\in\mathbb{R}}

.
Magnitude of physiological curvatures of the spine and the incidence of contractures of selected muscle groups in students
Authors: Olszewska Elżbieta , Tabor Piotr , Czarniecka Renata 
Published: February 2018

Summary
Study aim: The aim of this study was to evaluate the incidence of contractures of selected muscle groups with respect to the magnitude of the physiological curvatures of the spine in young men with above-average levels of physical activity.
Material and methods: The study included 96 students at the University of Physical Education in Warsaw aged between 20 and 22 years (21.2 ± 1.05). Ninety-five percent of the students participated in sports training activities. The study was conducted between January and February 2016. The selected traits of the body posture were evaluated with an inclinometer, which was used to measure the inclination angles of sections of the spine relative to the vertical. The ranges of motion in the shoulder complex and the pelvic complex were measured with a goniometer. Values of 175º (for the shoulder complex) and 174° (for the hip joint) were assumed to indicate a decreased range of motion.
Results: The analysis of the individual results concerning mobility disorders in the shoulder complex and the pelvic complex revealed significant abnormalities in the researched group of students. About 90% of the study participants showed contrac­tures of selected muscle groups within the shoulder girdle, primarily in the right upper limb. Similar results were obtained for the incidence of contractures in the flexors of the hip joint. Flexion contractures in the hip joint were observed in around 84% of the participants, primarily in the left lower limb. The correlations between the inclination angles of the sections of the spine relative to the vertical and the ranges of motion in the shoulder complex and the pelvic complex, established using Pearson correlation coefficients, were ambiguous. The angles γ, β1 and α were inversely proportional to the range of raising motions of the upper limbs through flexion, where the correlation coefficients of all angles were statistically significant. Similar tendencies were observed for the correlations between the angles β2, β1 and α and the range of the extension movements at the hip joint, although the correlation coefficients were statistically significant only in the case of the angle β1.
Conclusions: Ranges of movement in the shoulder complex and pelvic complex have an influence on magnitude of physiologi­cal curvatures of the spine and the functioning of body posture.