bluuebunny/crossref_metadata_2025_split huggingface dataset:
Menstrual cycle rhythmicity: metabolic patterns in healthy women
Authors: Draper C. F. , Duisters K. , Weger B. , Chakrabarti A. , Harms A. C. , Brennan L. , Hankemeier T. , Goulet L. , Konz T. , Martin F. P. , Moco S. , van der Greef J. 
Published: September 2018

AbstractThe menstrual cycle is an essential life rhythm governed by interacting levels of progesterone, estradiol, follicular stimulating, and luteinizing hormones. To study metabolic changes, biofluids were collected at four timepoints in the menstrual cycle from 34 healthy, premenopausal women. Serum hormones, urinary luteinizing hormone and self-reported menstrual cycle timing were used for a 5-phase cycle classification. Plasma and urine were analyzed using LC-MS and GC-MS for metabolomics and lipidomics; serum for clinical chemistries; and plasma for B vitamins using HPLC-FLD. Of 397 metabolites and micronutrients tested, 208 were significantly (p < 0.05) changed and 71 reached the FDR 0.20 threshold showing rhythmicity in neurotransmitter precursors, glutathione metabolism, the urea cycle, 4-pyridoxic acid, and 25-OH vitamin D. In total, 39 amino acids and derivatives and 18 lipid species decreased (FDR < 0.20) in the luteal phase, possibly indicative of an anabolic state during the progesterone peak and recovery during menstruation and the follicular phase. The reduced metabolite levels observed may represent a time of vulnerability to hormone related health issues such as PMS and PMDD, in the setting of a healthy, rhythmic state. These results provide a foundation for further research on cyclic differences in nutrient-related metabolites and may form the basis of novel nutrition strategies for women.
Tunable phonon blockade in weakly nonlinear coupled mechanical resonators via Coulomb interaction
Authors: Sarma Bijita , Sarma Amarendra K. 
Published: September 2018

AbstractRealizing quantum mechanical behavior in micro- and nanomechanical resonators has attracted continuous research effort. One of the ways for observing quantum nature of mechanical objects is via the mechanism of phonon blockade. Here, we show that phonon blockade could be achieved in a system of two weakly nonlinear mechanical resonators coupled by a Coulomb interaction. The optimal blockade arises as a result of the destructive quantum interference between paths leading to two-phonon excitation. It is observed that, in comparison to a single drive applied on one mechanical resonator, driving both the resonators can be beneficial in many aspects; such as, in terms of the temperature sensitivity of phonon blockade and also with regard to the tunability, by controlling the amplitude and the phase of the second drive externally. We also show that via a radiation pressure induced coupling in an optomechanical cavity, phonon correlations can be measured indirectly in terms of photon correlations of the cavity mode.
Partial depletion of CD206-positive M2-like macrophages induces proliferation of beige progenitors and enhances browning after cold stimulation
Authors: Igarashi Yoshiko , Nawaz Allah , Kado Tomonobu , Bilal Muhammad , Kuwano Takahide , Yamamoto Seiji , Sasahara Masakiyo , Jiuxiang Xu , Inujima Akiko , Koizumi Keiichi , Imura Johji , Shibahara Naotoshi , Usui Isao , Fujisaka Shiho , Tobe Kazuyuki 
Published: September 2018

AbstractBeige adipocytes are an inducible form of thermogenic adipocytes that become interspersed within white adipose tissue (WAT) depots in response to cold exposure. Previous studies have shown that type 2 cytokines and M2 macrophages induce cold-induced browning in inguinal WAT (ingWAT) by producing catecholamines. Exactly how the conditional and partial depletion of CD206+ M2-like macrophages regulates the cold-induced browning of ingWAT, however, remains unknown. We examined the role of CD206+ M2-like macrophages in the cold-induced browning of WAT using genetically engineered CD206DTR mice, in which CD206+ M2-like macrophages were conditionally depleted. The partial depletion of CD206+ M2-like enhanced UCP1 expression in ingWAT, as shown by immunostaining, and also upregulated the expression of Ucp1 and other browning-related marker genes in ingWAT after cold exposure. A flow cytometry analysis showed that the partial depletion of CD206+ M2-like macrophages caused an increase in the number of beige progenitors in ingWAT in response to cold. Thus, we concluded that CD206+ M2-like macrophages inhibit the proliferation of beige progenitors and that the partial depletion of CD206+ M2-like macrophages releases this inhibition, thereby enhancing browning and insulin sensitivity.
Extensive Vibrational Characterisation and Long-Term Monitoring of Honeybee Dorso-Ventral Abdominal Vibration signals
Authors: Ramsey M. , Bencsik M. , Newton M. I. 
Published: September 2018

AbstractA very common honeybee signal is the dorso-ventral abdominal vibration (DVAV) signal, widely accepted as a modulatory signal meaning: “prepare for greater activity”. In this study, using ultra-sensitive accelerometer technology embedded in the honeycomb, we visually confirm the one-to-one relationship between a DVAV signal being produced and the resulting accelerometer waveform, allowing the measurement of DVAV signals without relying on any visual inspection. We then demonstrate a novel method for the continuous in-situ non-invasive automated monitoring of this honeybee signal, not previously known to induce any vibration into the honeycomb, and most often inaudible to human hearing. We monitored a total of three hives in the UK and France, showing that the signal is very common, highly repeatable and occurs more frequently at night, exhibiting a distinct decrease in instances and increase in amplitude towards mid-afternoon. We also show an unprecedented increase in the cumulative amplitude of DVAV signals occurring in the hours preceding and following a primary swarm. We conclude that DVAV signals may have additional functions beyond solely being a foraging activation signal, and that the amplitude of the signal might be indicative of the switching of its purpose.
Engineering functional BMP-2 expressing teratoma-derived fibroblasts for enhancing osteogenesis
Authors: Go Yoon Young , Mun Ji Yeon , Chae Sung-Won , Kim Shin Hye , Song Hoseok , Song Jae-Jun 
Published: September 2018

AbstractBone morphogenetic protein 2 (BMP-2) is considered an effective growth factor for bone formation, and is used for making osteo-inductive scaffolds, but the related clinical investigations have shown low success rates. In this study, we genetically manipulated teratoma-derived fibroblast (TDF) cells by simultaneous introduction of BMP-2 and herpes simplex virus-thymidine kinase (HSV-tk) encoding genes. Self-production of BMP-2 in TDF cells strongly enhanced the alkaline phosphatase (ALP) activity, calcium content, and elevated the mRNA expression of osteogenic marker genes during in vitro osteogenesis. The bone formation volume was also remarkably enhanced in calvarial and femoral critical-size defect models. Ganciclovir (GCV) treatment induced apoptosis in TDF cells co-expressing HSV-tk and BMP-2, implying that HSV-tk suicide gene can modulate the side-effects of stem cell therapy, e.g., development of uncontrollable teratoma and tumor formation. Altogether, our findings revealed a safe and highly efficient technique with potential therapeutic applications for bone regeneration.
Dislocation avalanche mechanism in slowly compressed high entropy alloy nanopillars
Authors: Hu Yang , Shu Li , Yang Qun , Guo Wei , Liaw Peter K. , Dahmen Karin A. , Zuo Jian-Min 
Published: September 2018

AbstractCrystals deform by the intermittent multiplication and slip avalanches of dislocations. While dislocation multiplication is well-understood, how the avalanches form, however, is not clear, and the lack of insight in general has contributed to “a mass of details and controversy” about crystal plasticity. Here, we follow the development of dislocation avalanches in the compressed nanopillars of a high entropy alloy, Al0.1CoCrFeNi, using direct electron imaging and precise mechanical measurements. Results show that the avalanche starts with dislocation accumulations and the formation of dislocation bands. Dislocation pileups form in front of the dislocation bands, whose giveaway trigs the avalanche, like the opening of a floodgate. The size of dislocation avalanches ranges from few to 102 nm in the nanopillars, with the power-law distribution similar to earthquakes. Thus, our study identifies the dislocation interaction mechanism for large crystal slips, and provides critical insights into the deformation of high entropy alloys.
An open database of productivity in Vietnam's social sciences and humanities for public use
Authors: Vuong Quan-Hoang , La Viet-Phuong , Vuong Thu-Trang , Ho Manh-Toan , Nguyen Hong-Kong T. , Nguyen Viet-Ha , Pham Hiep-Hung , Ho Manh-Tung 
Published: September 2018

AbstractThis study presents a description of an open database on scientific output of Vietnamese researchers in social sciences and humanities, one that corrects for the shortcomings in current research publication databases such as data duplication, slow update, and a substantial cost of doing science. Here, using scientists’ self-reports, open online sources and cross-checking with Scopus database, we introduce a manual system and its semi-automated version of the database on the profiles of 657 Vietnamese researchers in social sciences and humanities who have published in Scopus-indexed journals from 2008 to 2018. The final system also records 973 foreign co-authors, 1,289 papers, and 789 affiliations. The data collection method, highly applicable for other sources, could be replicated in other developing countries while its content be used in cross-section, multivariate, and network data analyses. The open database is expected to help Vietnam revamp its research capacity and meet the public demand for greater transparency in science management.
Driver's dashboard – using social media data as additional information for motorway operators
Authors: Neuhold Robert , Gursch Heimo , Kern Roman , Cik Michael 
Published: September 2018

Data collection on motorways for traffic management operations is traditionally based on local measurement points and camera monitoring systems. This work looks into social media as an additional data source for the Austrian motorway operator ASFINAG. A system called Driver's Dashboard was developed collecting incident descriptions from Facebook and RSS feeds, filtering relevant messages, and fusing them with traffic data. All collected texts were analysed for concepts describing road situations linking the texts from the web and social media with traffic messages and traffic data. Driver's Dashboard was designed to examine the potential of social media for traffic monitoring with respect to Austrian characteristics in social media use and road transportation with only very few messages available compared with other studies. Of 3586 messages collected within a five‐week period, only 7.1% were automatically annotated as traffic relevant. Furthermore, the traffic relevant messages for the motorway operator were analysed more in detail to identify correlations between message text and traffic data characteristics. A correlation between message text and traffic data was found in nine of 11 messages by comparing the speed profiles and traffic state data with the message text.
Milky Way metallicity gradient from Gaia DR2 F/1O double-mode Cepheids
Authors: Lemasle B. , Hajdu G. , Kovtyukh V. , Inno L. , Grebel E. K. , Catelan M. , Bono G. , François P. , Kniazev A. , da Silva R. , Storm J. 
Published: September 2018

Context. The ratio of the first overtone (1O)/fundamental (F) periods of mixed-mode Cepheids that pulsate simultaneously in these two modes (F/1O) is metallicity-dependent. It can therefore be used to characterize the systems that host such variable stars.
Aims. We want to take advantage of the F/1O double-mode Cepheids listed in the Gaia Data Release 2 (DR2) catalog to derive the metallicity gradient in the Milky Way disk.
Methods. The metallicity is derived from the ratio of the first overtone and fundamental periods provided by Gaia DR2 while the Gaia DR2 parallaxes are used to determine the Galactocentric distances of the stars.
Results. From a visual inspection of the light curves, it turns out that a large fraction (77%) of the Galactic F/1O double-mode Cepheids in Gaia DR2 are spurious detections. Gaia DR2 provides three new bona fide F/1O Cepheids. Combining them with the currently known F/1O Cepheids and using the Gaia DR2 parallaxes for the entire sample, we can derive the metallicity gradient in the Milky Way disk. We find a slope of –0.045 ± 0.007 dex kpc−1 using a bootstrap method, and of –0.040 ± 0.002 dex kpc−1 using a total least squares method. These results are in good agreement with previous determinations of the [Fe/H] gradient in the disk based on canonical Cepheids.
Conclusions. The period ratio of F/1O Cepheids allows for a reliable determination of the metallicity gradient in the Milky Way, and in turn, in other systems that would be difficult to reach via classical spectroscopic methods.
Effect of Static Stretching with Superficial Cooling on Muscle Stiffness
Authors: Nakamura Masatoshi , Hirabayashi Ryo , Ohya Shuhei , Aoki Takafumi , Suzuki Daichi , Shimamoto Mitsuki , Kikumoto Takanori , Ito Wataru , Nakamura Emi , Takabayashi Tomoya , Edama Mtsuaki 
Published: September 2018

AbstractThis study aimed to clarify the acute effect of static stretching (SS) with superficial cooling on dorsiflexion range of motion (DF ROM) and muscle stiffness. Sixteen healthy males participated in the cooling condition and a control condition in a random order. The DF ROM and the shear elastic modulus of medial gastrocnemius (MG) in the dominant leg were measured during passive dorsiflexion. All measurements were performed prior to (PRE) and immediately after 20 min of cooling or rested for 20 min (POST), followed by 2 min SS (POST SS). In cooling condition, DF ROM at POST and POST SS were significantly higher than that at PRE and DF ROM at POST SS was significantly higher than that at POST. In addition, the shear elastic modulus at POST was significantly higher than that at PRE and the shear elastic modulus at POST SS was significantly lower than those at PRE and POST. However, there were no significant differences in the percentage changes between PRE and POST SS between the cooling and control conditions. Our results showed that effects of SS with superficial cooling on increases in ROM and decrease in muscle stiffness were no more beneficial than those of SS alone.
Gross Total Resection of a Jugular Foramen Thyroid Medullary Metastasis via a Transjugular Transsigmoid Approach
Authors: Aydin Ilhan , Sayyahmelli Sima , Pyle Mark , Baskaya Mustafa 
Published: September 2018

Surgical resection of jugular foramen tumors poses a significant challenge to skull base surgeons with the selection of an appropriate surgical approach, a matter of some debate. Jugular foramen metastatic tumors may mimic paragangliomas, and in some selected cases surgical resection is needed. In this video, we demonstrate the microsurgical gross total resection of a jugular foramen tumor via a postauricular trans-jugular trans-sigmoid approach. The patient is a 61-year-old man with a 7-year history of medullary thyroid cancer, who underwent three neck operations and radiation to the neck. He developed lower cranial nerve palsies (IX, X, and XI) with preoperative aspiration deficits, dysphonia, status post phonosurgery for vocal cord paralysis, profound sensorineural hearing loss, and muscle atrophy of the left shoulder. He initially received stereotactic radiation of the jugular foramen tumor at an outside hospital without histopathological diagnosis. Follow-up magnetic resonance images (MRIs) showed progressive enlargement of the tumor over the postradiation year. The decision was made to resect this tumor to enable histopathological diagnosis, and to provide local tumor control, since his primary disease has been stable. He underwent microsurgical gross total resection via a transjugular transsigmoid approach. After skeletonizing the sigmoid sinus and jugular bulb, the sigmoid sinus was ligated and rolled toward the jugular bulb, where the major part of the tumor was. Then, using the transjugular route, the tumor was removed en bloc. The surgery and postoperative course were uneventful. The histopathology was a thyroid medullary cancer metastasis. He was followed with serial MRIs, and there was no recurrent tumor at 2 years follow-up. In this video, microsurgical techniques and important steps for the resection of a jugular foramen metastatic tumor are demonstrated.The link to the video can be found at: https://youtu.be/oXC6fX2CC84.
Microsurgical Gross Total Resection of a Large Residual/Recurrent Vestibular Schwannoma via Translabyrinthine Approach
Authors: Sayyahmelli Sima , Roche Joseph , Baskaya Mustafa 
Published: September 2018

Although, gross total resection in large vestibular schwannomas is an ideal goal, subtotal resection is frequently performed due to lack of expertise, concerns for facial palsy, or overuse of stereotactic radiation. In this video, we present a 31-year-old man with a 7-year history of tinnitus, dizziness, and hearing loss. The patient had a subtotal resection of a 2.5 cm right-sided vestibular schwannoma via retrosigmoid craniotomy at an outside hospital. He was referred for further surgical resection due to the increased size of the tumor on surveillance magnetic resonance imagings (MRIs) and worsening symptoms. MRI showed a residual/recurrent large schwannoma with extension to the full length of the internal acoustic canal and brain stem compression. He underwent microsurgical gross total resection via a translabyrinthine approach. The facial nerve was preserved and stimulated with 0.15 mA at the brainstem entry zone. He awoke with House–Brackmann grade III facial function, with an otherwise uneventful postoperative course. In this video, microsurgical techniques and important resection steps for this residual/recurrent vestibular schwannoma are demonstrated, and nuances for microsurgical technique are discussed.The link to the video can be found at: https://youtu.be/a0ZxE41Tqzw.
Extended Retrosigmoid Approach for the Resection of a Pontomedullary Junction Cavernous Malformation
Authors: Basma Jaafar , Nguyen Vincent , Sorenson Jeffrey , Michael L. 
Published: September 2018

Objectives To describe an extended retrosigmoid approach for the resection of a cavernoma involving the ponto-medullary junction, with emphasis on the microsurgical anatomy and technique.
Design A retrosigmoid craniotomy is performed in the lateral decubitus position and the sigmoid sinus exposed. After opening the dura, sutures are placed medial to the sinus to allow its gentle mobilization. Cerebrospinal fluid (CSF) is drained from the cisterna magna, and cerebellopontine cistern, and dynamic retraction is used over the cerebellum. Subarachnoid dissection of the cerebellopontine angle gives access to cranial nerves IX/X, VII/VIII, and VI. Inspection of the pontomedullary junction medial to the facial nerve reveals hemosiderin staining in that region. A small pial opening is made, exposing the hemorrhagic cavity. The cavernous malformation is then identified, dissected circumferentially, and resected. Photographs of the region are borrowed from Dr Rhoton's laboratory to illustrate the microsurgical anatomy.
Participants The senior author performed the surgery. The video was edited by Drs. J.B. and V.N.
Outcome Measures Outcome was assessed with extent of resection and postoperative neurological function.
Results A gross total resection of the lesion was achieved. The patient did not develop any postoperative deficits.
Conclusion Understanding the microsurgical anatomy of the cerebellopontine angle and meticulous microneurosurgical technique are necessary to achieve a complete resection of a brainstem cavernoma. The extended retrosigmoid approach provides an adequate corridor to the pontomedullary junction.The link to the video can be found at: https://youtu.be/FIKixWJT75w.
Evaluation of Voiding Dysfunction in Patients with Traumatic Brain Injury
Authors: Kumar Amit , Vaddi Suryaprakash , Gouru Vijayabhaskar , Agrawal Amit 
Published: September 2018

Abstract
Introduction Voiding dysfunction after a traumatic brain injury (TBI) occurs secondary to impaired cognitive or behavioral functioning, brain damage, associated injury to the spinal cord, and direct bladder trauma. In this study, the authors collected data on TBI patients with neurogenic bladder dysfunctions to understand the spectrum of voiding dysfunctions and to investigate the relationships of the severity of TBI with the presentation of urinary tract dysfunctions.
Materials and Methods All consecutive patients with isolated TBI of Glasgow Coma Scale (GCS) (9–15) in the postacute period and at 3 months were included in the study. In patients with previous stroke or any other neurologic disorder or associated spine injury and with urologic conditions such as benign prostatic hyperplasia (BPH), the urethral stricture is excluded. After a successful voiding trial, uroflowmetry to see the flow pattern and ultrasound of the abdomen and pelvis for post-void residual urine is done. A urodynamic study is done in patients with poor urinary flow (< 15 mL/s), high post-void residual urine (> 100 mL), and/or lower urinary tract symptoms.
Results During the study period, a total of 55 patients were enrolled in the study: 43 were males and 12 were females. Out of 55 patients, 47 were treated conservatively and 8 were operated upon for TBI. Out of 55 patients, 26 had a poor stream on uroflowmetry and 19 underwent urodynamic study either due to urinary symptoms or poor stream. Out of the 19 patients, 9 had a urodynamic abnormality. Of the 19 patients who underwent urodynamic study, there was no significant correlation (p = 0.23) between the TBI pathology and urodynamic abnormality. There was also no significant correlation seen between site of lesion and urodynamic abnormality.
Conclusion The prevalence of urinary symptoms in mild and moderate TBIs is low (7.3); 47.7% of patients had poor urinary flow. None of the patients had an abnormality in filling phase. Nine patients had an abnormality in voiding phase and were treated with an α-blocker.
Duration During 2012 to 2015.
The unconditioned in philosophy of religion
Authors: Shakespeare Steven 
Published: September 2018

AbstractThis article argues that philosophy of religion should focus on the notion of the unconditioned, rather than God. Such a shift of focus would have a number of advantages. It would loosen the grip of the default theistic framework often used in the field. In turn, this would encourage fresh reflection upon the nature of the unconditioned and its relationship to conditioned entities. In the process, it would facilitate critical conversation about fundamental metaphysical issues across the divide between analytic and continental philosophers. As an initial step, this article offers a working definition of the unconditioned and explores significant developments of the idea through Kant and the early work of Schelling. It argues that light can be cast on the notion of the unconditioned by contemporary analytic debates about essence and grounding, and vice versa. In order to suggest the fruitfulness of this approach, a recent essay in philosophy of religion by Daniel Barber is examined, in which the unconditioned is presented as a differential field immanent to what it conditions; and in which conditioned entities are understood through the notion of modal essence. The article ends with a summary of the advantages of refocusing philosophy of religion on the unconditioned, not least in enabling the discipline to take seriously non-theistic and non-transcendent approaches to ultimate reality.