bluuebunny/crossref_metadata_2025_split huggingface dataset:
Psychosocial characteristics of blood donors influence their voluntary nonmedical lapse
Authors: Merz Eva‐Maria , Ferguson Eamonn , van Dongen Anne 
Published: November 2018

BACKGROUNDApproximately 10% of Dutch donors lapse yearly. Common reasons are nonvoluntary medical issues (e.g., low hemoglobin), reaching the upper age limit, and voluntary (e.g., own request, nonresponse). Little is known about predictors of voluntary noncompliance (lapses). Psychosocial characteristics have been linked to various health behaviors, including voluntary noncompliance. Hence, we investigated whether psychosocial characteristics, measured before the first donation, similarly predict subsequent voluntary nonmedical lapse.STUDY DESIGN AND METHODSNew donors (n = 4861) randomly received a blood donation survey between July 2008 and March 2009, before their first appointment at the blood bank. Voluntary lapses included personal reasons, nonresponse to invitations, donor who could not be reached, and no show. Univariate and multivariate Cox regression models of lapse on psychosocial characteristics and confounders (e.g., demographics) were estimated.RESULTSOf 2964 donors who took the questionnaire, more than one‐third (36.5%) had voluntarily lapsed due to nonmedical reasons by 2016. Univariate regression showed that lapse negatively associated with norms, attitudes, and intentions toward blood donation; self‐efficacy; and more donation experience. Lapse positively associated with anxiety. Multivariate Cox models showed that lapse was primarily driven by anxiety and need for information.CONCLUSIONCertain psychosocial characteristics increase risks of voluntary lapse. Especially donors with higher donation anxiety had increased lapsing risks. They might benefit from extra attention during donation. Donors with more information need or wish about procedure and patients were less likely to lapse, indicating that binding with the blood bank might prevent lapse. Generally, this study showed that donor lapse and donor return are determined by different psychosocial factors not just the reverse of each other.
Validation of an ELISA for detection of neutrophil gelatinase‐associated lipocalin (NGAL) in equine serum
Authors: Jacobsen Stine , Berg Lise C. , Tvermose Emil , Laurberg Malene B. , van Galen Gaby 
Published: November 2018

BackgroundNeutrophil gelatinase‐associated lipocalin (NGAL) has been shown to be a useful marker of kidney injury in people and dogs, but has not been described in horses.ObjectivesThe aim of the study was to validate a commercially available porcine‐specific ELISA to measure serum concentrations of equine NGAL.MethodsIntra‐ and interassay imprecisions were evaluated by multiple measurements on equine serum pools. Assay inaccuracy was determined by the linearity under dilution. Overlapping performance was assessed by measuring NGAL concentrations in horses with normal and elevated serum creatinine levels.ResultsIntra‐ and interassay imprecision (coefficient of variation) ranged from 5.35% to 28.39%. The ELISA showed no signs of inaccuracy. Overlapping performance was acceptable, as the assay was able to detect the expected differences of NGAL levels in horses with normal and elevated serum creatinine concentrations.ConclusionsEquine serum NGAL concentrations could be quantified reliably using the porcine‐specific ELISA.
Outcome following cosmetic rostral nasal reconstruction after planectomy in 26 dogs
Authors: Dickerson Vanna M. , Grimes Janet A. , Vetter Catherine A. , Colopy Sara A. , Duval Julie M. , Northrup Nicole C. , Schmiedt Chad W. 
Published: November 2018

AbstractObjectiveTo report the outcome and owner satisfaction after planectomy for nasal planum neoplasia with cosmetic reconstruction with bilateral labial mucocutaneous rotation flaps in dogs.Study designMulti‐institutional, retrospective case series.AnimalsTwenty‐six client‐owned dogs.MethodsMedical records were searched for dogs that had undergone the procedure. Signalment, diagnosis, surgery, complications, requirement for revision surgery, recurrence, and survival information were recorded. Owners were contacted by telephone about their dog's quality of life after the procedure and their satisfaction with their dog's outcome.ResultsTwenty‐five dogs underwent radical planectomy, and 1 dog underwent resection of the nasal planum. Twenty‐four dogs had a diagnosis of squamous cell carcinoma, 1 had a diagnosis of atypical adenocarcinoma, and 1 had a diagnosis of a mast cell tumor. Complications occurred in 19 (73%) dogs, with 9 dogs requiring revision surgery; 1 dog not surviving to discharge. Median survival time was 1542 days (range, 3‐2010). Recurrence of the primary tumor was suspected in 2 (7.7%) dogs, both with narrow or incomplete excision. Among 11 owners interviewed, 10 were satisfied with their dog's appearance, and 8 reported they would consent to the procedure again.ConclusionDehiscence was common after this procedure, but local tumor control and survival times were excellent. Owner satisfaction was high, although preoperative client education is vital.Clinical significanceThis technique should be considered as a viable option for dogs with nasal planum neoplasia given the high rate of recurrence with less aggressive treatment. Complications common following surgery, but do not persist long term and survival times were excellent.
MATHEMATICS LEARNING BASED ISLAMIC ECONOMY USING MIND MAP PAINTING
Authors: Widayati Farida Esti , Nur Sholikhah Ayuk , Prabowo Ade , Nizam Muhammad 
Published: November 2018

This paper describes about a mathematics learning based on fiqh (Islamic economic) and assisted by mind map painting. The learning objectives of this paper are not only to construct students' knowledge of learning materials, but also inculcate moral values based on the science of fiqh (Islamic economic). It is as stated in the national learning goals is to establish the appropriate nature of religious norms, knowledgeable and creative. One of the mathematics instructional materials contained in the science of fiqh (Islamic economic) is a social arithmetic. In this paper,it is asocial learning arithmetic using mind map painting. Mind map painting capable of developing the mind and improving the memory. Moreover, mind map painting capable of improving the absorption of information, problem solving and increase ability to think. Syntax learning in this paper, namely, 1) the opening, starting together to read and understand the gist of one letter of the Qur'an, 2) the core activities, the provision of video illustration initial problems, the provision of material and finish problem of the video, create a mind map painting and present it to the class, 3) cover, giving feedback on the presentations and jointly concluded learning outcomes. So the learning mathematics based on Islamic economy using mind map painting is expected to construct students' knowledge and foster the student's character based on the science of fiqh (Islamic economic).
FAKTOR DORONGAN PERSAMBUNGAN SANAD KITAB HADIS DALAM PENGAJIAN TALAQQI BERSANAD DI MALAYSIA(THE MOTIVATIONAL FACTORS BEHIND CONTINUOUS "SANAD" IN THE LEARNING OF "TALAQQI BERSANAD" IN MALAYSIA)
Authors: Mohd. Ramli Farhah Zaidar , Abdul Majid Latifah , Nazri Mohd Arif 
Published: November 2018

Talaqqi with Sanad (TB) is one of the teaching approach Islamic tradition, in which it is conducted directly in front of of the al-musnid (teacher). It is practiced through a combination of al-samac, al-qira'ah and al-ijazah methods. These three methods are adapted until now in narrating the compilition of hadiths of the Prophet S.A.W from various books (kitab) with no exception a compilation of hadith from great books like Sahih al-Bukhari. The major implication of TB application is the continuation of sanad genealogy between the teachers and the students until it reaches to the compilers of the book of hadiths. The summit of the genealogy of the book will link back to the source of hadiths that is from the Prophet S.A.W. TB phenomenon was also recorded systematically by the figures of hadiths as the al-musnid in the works known as al-thabat beginning in the sixth century until the fifteenth century Hijri. However in Malaysia, TB tradition is very little known and rarely practiced. Even so, the qualitative analysis derived from the documents and interviews shows that the phenomenon of sanad continuation through TB in Malaysia still continues to be applied by the local al-musnid teachers based on four motivating factors, namely the preservation of sanad genealogy, chain affiliation ties of sanad with the Prophet S.A.W as well as his heir, the exemplary tradition of expert knowledge and the care of sanad cali. All of these encouragements also show the importance of the function of sanad to the book of hadith nowadays, in which its sustainability should be continued through the application of TB.
Coronary artery aneurysms are more severe in infants than in older children with Kawasaki disease
Authors: Cameron Scott A , Carr Michael , Pahl Elfriede , DeMarais Nicole , Shulman Stanford T , Rowley Anne H 
Published: November 2018

ObjectiveWe aimed to compare the severity of coronary artery abnormalities in Kawasaki disease between infants and older children.MethodsWe retrospectively reviewed and compared coronary artery dilation and aneurysm severity in infants <1 year of age with Kawasaki disease at our centre over a 10-year period with that observed in children ≥1 year of age in the Pediatric Heart Network Trial of Pulse Steroid Therapy in Kawasaki Disease. Coronary artery abnormalities were defined by z-scores according to American Heart Association guidelines.ResultsOf the 93 infants identified during the study period, 80 were treated with intravenous gamma globulin within the first 10 days of illness and were included for comparison to 170 children ≥1 year of age treated in the same time frame from the Pediatric Heart Network public database. The mean maximum z-score was significantly higher in infants compared with older children (3.37 vs 2.07, p<0.001). A higher incidence of medium and giant aneurysms was observed in infants compared with children ≥1 year of age (11% vs 3% for medium aneurysms, p=0.015; 8% vs <1% for giant aneurysms, p=0.005).ConclusionsInfants with Kawasaki disease have more severe coronary artery dilation compared with older children, and a higher prevalence of medium and giant aneurysms. Because adverse outcomes are closely linked to the maximal coronary artery diameter in Kawasaki disease, patients diagnosed as infants require very close long-term monitoring for cardiac complications.
Physical activity on prescription in accordance with the Swedish model increases physical activity: a systematic review
Authors: Onerup Aron , Arvidsson Daniel , Blomqvist Åse , Daxberg Eva-Lotte , Jivegård Lennart , Jonsdottir Ingibjörg H , Lundqvist Stefan , Mellén Anders , Persson Josefine , Sjögren Petteri , Svanberg Therese , Borjesson Mats 
Published: November 2018

ObjectivesThis study investigates the effects of the core elements of the Swedish model for physical activity on prescription (PAP) by evaluating studies that compared adults who received PAP with adults who did not receive PAP. All participants were adults identified by a healthcare professional as in need of increased physical activity. Primary outcome was level of physical activity.DesignSystematic review.Eligibility criteria(1) Published 1999. (2) Systematic review, randomised controlled trial (RCT), non-RCT or case series (for adverse events). (3) ≥12 weeks’ follow-up. (4) Performed in the Nordic countries. (5) Presented in English, Swedish, Norwegian or Danish.Data sourcesSystematic searches in PubMed, Embase, the Cochrane Library, AMED, CINAHL and SweMed+ in September 2017. Included articles were evaluated using checklists to determine risk of bias.ResultsNine relevant articles were included: seven RCTs, one cohort study and one case series. Primary outcome was reported in seven articles from six studies (five RCTs, one cohort study, 642 participants). Positive results were reported from three of the five RCTs and from the cohort study. No study reported any negative results. Swedish PAP probably results in an increased level of physical activity (GRADE⊕⊕⊕Ο).ConclusionsAlthough the number of the reviewed articles was relatively modest, this systematic review shows that PAP in accordance with the Swedish model probably increases the level of physical activity. As a model for exercise prescription, Swedish PAP may be considered as part of regular healthcare to increase physical activity in patients.
Subclinical coronary artery disease in veteran athletes: is a new preparticipation methodology required?
Authors: Dores Hélder , de Araújo Gonçalves Pedro , Monge José , Costa Rogério , Tátá Luis , Malhotra Aneil , Sharma Sanjay , Cardim Nuno , Neuparth Nuno 
Published: November 2018

Objective
Preparticipation evaluation of veteran athletes should focus on accurate cardiovascular (CV) risk stratification and subclinical detection of coronary artery disease (CAD), which is the main cause of sudden cardiac death in this population. We aimed to investigate the effectiveness of current preparticipation methodology used to identify veteran athletes with high coronary atherosclerotic burden.

Methods
A total of 105 asymptomatic male athletes aged ≥40 years old, with low to moderate CV risk (Systematic Coronary Risk Estimation <5%) who trained ≥4 hours/week for at least 5 years, were studied. The screening protocol included clinical evaluation, ECG, transthoracic echocardiogram and exercise testing. Cardiac CT was performed to detect CAD, defined as a high atherosclerotic burden according to coronary artery calcium score and coronary CT angiography.

Results
The majority of the athletes (n=88) engaged in endurance sports, with a median volume of exercise of 66 (44; 103) metabolic equivalent task score/hour/week. Exercise testing was abnormal in 13 (12.4%) athletes, 6 (5.7%) with electrocardiographic criteria for myocardial ischaemia and 7 (6.7%) with exercise-induced ventricular arrhythmias. A high coronary atherosclerotic burden was present in 27 (25.7%) athletes, of whom 11 (40.7%) had CV risk factors and 6 had abnormal exercise tests, including 3 who were positive for myocardial ischaemia.

Conclusions
Conventional methodology used in preparticipation evaluation of veteran athletes, based on clinical CV risk factors and exercise testing, was poor at identifying significant subclinical CAD. The inclusion of more objective markers, particularly data derived from cardiac CT, is promising for more accurate CV risk stratification of these athletes.
Inconsistent condom use with known HIV-positive partners among newly diagnosed HIV-positive men who have sex with men interviewed for partner services in New York City, 2014
Authors: Burton Nicole Theresa , Misra Kavita , Bocour Angelica , Shah Sharmila , Gutierrez Rodolfo , Udeagu Chi-Chi 
Published: November 2018

ObjectivesCondomless anal intercourse contributes significantly to the spread of HIV among men who have sex with men (MSM). Factors related to condomless anal intercourse with known HIV-positive partners among MSM are not well understood. The authors describe factors associated with inconsistent condom use with known HIV-positive partners prior to participants’ diagnosis with HIV.MethodsNew York City health department disease intervention specialists interviewed newly HIV-diagnosed MSM ages ≥13 years reporting knowingly having anal sex with HIV-positive partners between June 2013 and October 2014. Univariate and bivariate statistics were calculated, in addition to logistic regression analysis.ResultsAmong 95 MSM interviewed, 56% were >30 years and 74% had higher than a high school education. Respondents reported a median of 2 known HIV-positive sex partners. Drug or alcohol use during last sex with their last known HIV-positive partner was reported by 53% of participants. Sixty-five per cent of participants reported inconsistent condom use with last known HIV-positive partner. Inconsistent condom use with all HIV-positive partners was higher among individuals reporting two or more known HIV-positive partners since sexual debut than among those with one (90% vs 59%, p<0.01) and among those reporting feelings of love/emotional attachment as a reason for having sex (85% vs 63%, p=0.02). In the bivariate logistic regression models for inconsistent condom use, feelings of love or emotional attachment were the only significant predictor of inconsistent condom use (OR 3.43, 95%  CI 1.23 to 9.58). After adjusting for confounding, the relationship feelings of love or emotional attachment continued to be the only significant predictor of inconsistent condom use (OR 3.69, 95%  CI 1.06 to 12.82).ConclusionsSurveyed MSM engaged in high-risk behaviours, including condomless anal sex and drug or alcohol use during sex with persons known to be HIV-positive. These findings can inform interventions with MSM in serodiscordant partnerships.
Reversal of right ventricular failure by chronic α1A-subtype adrenergic agonist therapy
Authors: Cowley Patrick M. , Wang Guanying , Swigart Philip M. , Raghunathan Anaha , Reddy Nikitha , Dulam Pranavi , Lovett David H. , Simpson Paul C. , Baker Anthony J. 
Published: November 2018

Right ventricular (RV) failure (RVF) is a serious disease with no effective treatment available. We recently reported a disease prevention study showing that chronic stimulation of α1A-adrenergic receptors (α1A-ARs), started at the time of RV injury, prevented the development of RVF. The present study used a clinically relevant disease reversal design to test if chronic α1A-AR stimulation, started after RVF was established, could reverse RVF. RVF was induced surgically by pulmonary artery constriction in mice. Two weeks after pulmonary artery constriction, in vivo RV fractional shortening as assessed by MRI was reduced by half relative to sham-operated controls (25 ± 2%, n = 27, vs. 52 ± 2%, n = 13, P < 10−11). Subsequent chronic treatment with the α1A-AR agonist A61603 for a further 2 wk resulted in a substantial recovery of RV fractional shortening (to 41 ± 2%, n = 17, P < 10−7 by a paired t-test) along with recovery of voluntary exercise capacity. Mechanistically, chronic A61603 treatment resulted in increased activation of the prosurvival kinase ERK, increased abundance of the antiapoptosis factor Bcl-2, and decreased myocyte necrosis evidenced by a decreased serum level of cardiac troponin. Moreover, A61603 treatment caused increased abundance of the antioxidant glutathione peroxidase-1, decreased level of reactive oxygen species, and decreased oxidative modification (carbonylation) of myofilament proteins. Consistent with these effects, A61603 treatment resulted in increased force development by cardiac myofilaments, which might have contributed to increased RV function. These findings suggest that the α1A-AR is a therapeutic target to reverse established RVF. NEW & NOTEWORTHY Currently, there are no effective therapies for right ventricular (RV) failure (RVF). This project evaluated a novel therapy for RVF. In a mouse model of RVF, chronic stimulation of α1A-adrenergic receptors with the agonist A61603 resulted in recovery of in vivo RV function, improved exercise capacity, reduced oxidative stress-related carbonylation of contractile proteins, and increased myofilament force generation. These results suggest that the α1A-adrenergic receptor is a therapeutic target to treat RVF.
Assessment of the influence of lung inflation state on the quantitative parameters derived from hyperpolarized gas lung ventilation MRI in healthy volunteers
Authors: Hughes Paul J. C. , Smith Laurie , Chan Ho-Fung , Tahir Bilal A. , Norquay Graham , Collier Guilhem J. , Biancardi Alberto , Marshall Helen , Wild Jim M. 
Published: November 2018

In this study, the effect of lung volume on quantitative measures of lung ventilation was investigated using MRI with hyperpolarized 3He and 129Xe. Six volunteers were imaged with hyperpolarized 3He at five different lung volumes [residual volume (RV), RV + 1 liter (1L), functional residual capacity (FRC), FRC + 1L, and total lung capacity (TLC)], and three were also imaged with hyperpolarized 129Xe. Imaging at each of the lung volumes was repeated twice on the same day with corresponding 1H lung anatomical images. Percent lung ventilated volume (%VV) and variation of signal intensity [heterogeneity score (Hscore)] were evaluated. Increased ventilation heterogeneity, quantified by reduced %VV and increased Hscore, was observed at lower lung volumes with the least ventilation heterogeneity observed at TLC. For 3He MRI data, the coefficient of variation of %VV was <1.5% and <5.5% for Hscore at all lung volumes, while for 129Xe data the values were 4 and 10%, respectively. Generally, %VV generated from 129Xe images was lower than that seen from 3He images. The good repeatability of 3He %VV found here supports prior publications showing that percent lung-ventilated volume is a robust method for assessing global lung ventilation. The greater ventilation heterogeneity observed at lower lung volumes indicates that there may be partial airway closure in healthy lungs and that lung volume should be carefully considered for reliable longitudinal measurements of %VV and Hscore. The results suggest that imaging patients at different lung volumes may help to elucidate obstructive disease pathophysiology and progression. NEW & NOTEWORTHY We present repeatability data of quantitative metrics of lung function derived from hyperpolarized helium-3, xenon-129, and proton anatomical images acquired at five lung volumes in volunteers. Increased regional ventilation heterogeneity at lower lung inflation levels was observed in the lungs of healthy volunteers.
Loss of the BCR-FGFR1 GEF Domain Suppresses RHOA Activation and Enhances B-Lymphomagenesis in Mice
Authors: Hu Tianxiang , Chong Yating , Lu Sumin , Qin Haiyan , Ren Mingqiang , Savage Natasha M. , Chang Chang-Sheng , Cowell John K 
Published: November 2018

Abstract

Transformation of hematopoietic stem cells by the BCR–FGFR1 fusion kinase found in a variant of stem cell leukemia/lymphoma (SCLL) syndrome leads to development of B-lymphomas in syngeneic mice and humans. In this study, we show that the relatively rapid onset of this leukemia is potentially related to oncogenic domains within the BCR component. BCR recruited a guanidine nucleotide exchange factor (GEF) domain to the fusion kinase to facilitate activation of small GTPases such as the Ras homology gene family, member A (RHOA). Deletion of this GEF domain increased leukemogenesis, enhanced cell survival and proliferation, and promoted stem cell expansion and lymph node metastasis. This suggests that, in an SCLL context, the presence of the endogenous GEF motif leads to reduced leukemogenesis. Indeed, loss of the GEF domain suppressed activation of RHOA and PTEN, leading to increased activation of AKT. Loss of the GEF domain enhanced cell proliferation and invasion potential, which was also observed in cells in which RHOA is knocked down, supported by the observation that overexpression of RHOA leads to reduced viability and invasion. In vivo depletion of RHOA in SCLL cells significantly increased disease progression and shortened latency. Collectively, these data show that the BCR GEF domain affects phenotypes associated with progression of SCLL through suppression of RHOA signaling.

Significance:
RHOA activation is a critical event in the progression of BCR–FGFR1–driven leukemogenesis in stem cell leukemia and lymphoma syndrome and is regulated by the BCR GEF domain.