bluuebunny/crossref_metadata_2025_split huggingface dataset:
Amphiphilic Gelator‐Based Shear‐Thinning Hydrogel for Minimally Invasive Delivery via Endoscopy Catheter to Remove Gastrointestinal Polyps
Authors: Dave Harshil , Vithalani Hitasha , Singh Hemant , Yadav Indu , Jain Abhinav , Pal Ankit , Patidar Nishant , Navale Archana , Dhanka Mukesh 
Published: November 2024

AbstractInjectable polymeric hydrogels delivered via endoscopic catheter have emerged as promising submucosal agents, offering durable, long‐lasting cushions to enhance the efficacy of endoscopic submucosal dissection (ESD) for the removal of small, flat polyps from the gastrointestinal tract (GIT). However, polymer‐based injections do not meet the easy‐injectability criteria via catheter because their high viscosity tends to clog the catheter needle. To the best of knowledge, for the first time, report the fabrication of an amphiphile‐based small molecule hydrogel of diglycerol monostearate (DGMS) that self‐assembles to form hydrogel (DGMSH) for delivery via an endoscopic catheter. Physicochemical characterization of the hydrogel reveals its fibrous morphology, shear‐thinning behaviour, and easy injectability, along with its scalability and long shelf‐life (6 months). Ex vivo studies on the goat's stomach and intestine demonstrate the ease of injectability through the catheters and the development of visible submucosal cushion depots with the desired height. Moreover, the hydrogel can encapsulate both hydrophobic and hydrophilic drugs/dyes. In vivo studies in small animals have found that the hydrogel depot is durable, biocompatible, non‐immunogenic, and has a hemostatic effect. Endoscopic studies in the porcine model demonstrate a safe injection and endoscopic excision of GI polyps acting as a suitable agent for ESD.
Clinical course and MRI lesion progression over 4 years in a dog with final diagnosis of high‐grade oligodendroglioma
Authors: Tomazi Fabiana Graciolli , Stein Veronika M. , Oevermann Anna , Meneses Felix , Maiolini Arianna 
Published: November 2024

AbstractA 9‐month‐old Cavalier King Charles Spaniel with 3‐month history of paroxysmal episodes of cervical pain and scratching had a magnetic resonance imaging revealing a large intra‐axial cystic lesion in the left frontal lobe, caudal transtentorial and foraminal brain herniation, and cervical syringomyelia. Despite suspected high‐grade glioma, clinical signs improved under palliative treatment. Follow‐up magnetic resonance imaging 2.5 years later showed a similar lesion size, with no radiological evidence of increased intracranial pressure. The differential diagnosis was reconsidered to possibly porencephaly, congenital cystic malformation or parasitic cyst. The dog remained clinically stable for 19 months before developing acute generalised, single, self‐limiting seizures, deteriorating to cluster seizures, stupor, cardiovascular arrest and death. Postmortem magnetic resonance imaging revealed lesion progression with ventricle invasion. Neuropathology confirmed a high‐grade oligodendroglioma with subarachnoid and intraventricular drop metastasis. This is the first report describing long‐term clinical course and magnetic resonance imaging lesion progression under palliative treatment of a dog ultimately diagnosed with high‐grade oligodendroglioma.
Nanoparticles Bounded to Interfering RNAs as a Therapy for Pancreatic Cancer: A Systematic Review
Authors: Lara Patricia , Quiñonero Francisco , Ortiz Raul , Prados Jose , Melguizo Consolación 
Published: November 2024

ABSTRACTPancreatic cancer is one of the tumors with poor prognosis and low survival due to late diagnosis, high resistance, and very limited effective therapeutic options. Thus, new pharmacological treatments are necessary to improve the prognosis of patients. In this context, nanoparticles represent an efficient system for transporting and administering therapeutic molecules. Furthermore, siRNA can be used in cancer treatment to selectively inhibit the expression of any target gene. Therefore, nanoparticles associated with siRNA have been tested as a new therapeutic strategy to solve the pancreatic cancer treatment failure in the clinical setting. The current article presents a systematic revision of the literature of the last 10 years in which nanoparticles loading siRNA are used in pancreatic cancer. This research was carried out in three databases (PubMed, Scopus, and Web of Science) obtaining 164 articles from which 37 were selected. Our results show an overall view of the high effectiveness of this new therapy that combines nanoparticles with genetic therapy in pancreatic cancer suggesting that siRNA‐based medicines will likely open up a new therapeutic era in the treatment of this type of tumors.
Experimental Study on Shear Characteristics of Gravelly Soil of Core Wall of Lianghekou Dam Under Freeze–Thaw Conditions
Authors: Zheng Bo , Liu Enlong 
Published: November 2024

AbstractIn order to study the mechanical properties of the upper loosely-paved gravelly soil used to protect the compacted dam material under the freeze–thaw cycle during winter construction on the engineering site, the gravelly soil with the soil-rock ratio of 7:3 was mixed evenly and sealed under the corresponding dry density and moisture content, and then subjected to freeze–thaw cycles. After reaching the corresponding freeze–thaw times, the compaction samples were taken out. The direct shear tests were conducted on gravelly soil after freeze–thaw cycles under different vertical pressures and the change pattern of mechanical properties were analyzed. The experimental results show that freeze–thaw cycles have no significant effect on the shear strength of soil samples under the lower vertical pressure. Under the higher vertical pressure, the shear strength of soil samples decreases with the number of freeze–thaw cycles and then stabilizes. The effect of freeze–thaw cycles on the shear strength parameters of the gravelly soil is more obvious. As the number of freeze–thaw cycles increases, the cohesive force tends to increase, while the internal friction angle decreases, tending to stabilization after 10 freeze–thaw cycles.
Analysis of the Saltwater Intrusion Prevention Effect of Pump for Ship Locks in the Estuary
Authors: Wang He , Li Chihong , Hu Yazhou , Zheng Jing , Chen Hong 
Published: November 2024

AbstractThis article comprehensively considers hydrogeological and meteorological conditions, including topography, tides, runoff, and wind. Integrating factors such as ship lock operation rules and tidal dynamic parameters, a two-dimensional tidal salinity model is established. The study further conducts computational analyses on the desalination effects of various pump operation processes in the newly constructed ship lock on the estuary. The results show that during the ship lock operation, saltwater plumes can enter inland rivers through tidal dynamics and accumulate on one side of the ship lock, leading to upstream propagation. In addition, high saltwater backflow and rapid upstream propagation of saltwater accumulation were observed during high tides. This study also studied the model calculation and analysis of anti-salt pump stations of different scales and operating processes, providing theoretical basis and technical support for engineering design plans.
Study on Progressive Failure Mechanism of High and Steep Overburden Slope Under Rainfall
Authors: Zhai Xing , Li Chenxi , Liu Yu , Li Hui 
Published: November 2024

AbstractThis paper summarizes the typical landslide characteristics and main triggering factors by statistically analyzing the detailed investigation data of 51 landslides in Hebei Province, among which rainfall-induced cover-type landslides are the most typical form of landslides. In order to study the destabilizing and destructive mechanism of high steep cover type slope under the action of rainfall infiltration, taking a cover type slope as an example, based on the theory of unsaturated seepage and shear strength, the changing rules of seepage field, displacement field, plasticity zone, and sliding cracking surface of the cover type slope under the condition of intermittent rainfall were analyzed by using the slip surface stress method, and the safety coefficient of the slope under the action of rainfall was calculated. The results show that: after the rainfall starts, because the shallow soil layer of the slope is mainly coarse gravel soil and gravel soil, with relatively strong permeability, the rainwater on the slope surface infiltrates into the interior of the slope body and softens the soil body along the soil-rock interface, and the soil body of the slope body produces displacement at the leading and trailing edges, and shallow sliding is formed in the slope; with the continuation of the rainfall, the slope produces a through plastic zone, and the soil body of the leading edge pulls the central pile body to produce traction slip, and the trailing edge of the soil body produces traction slip, and the trailing edge of the soil body produces traction slip. As the rainfall continues, the slope produces through plastic zone, the leading edge soil body pulls the central pile body to produce traction slip, the trailing edge soil body pushes the central pile body to produce nudging slip, and the deformation gradually develops from the surface to the depth, from the leading edge to the trailing edge.
Study on Risk Assessment Method of Cascade Reservoirs Based on Hidden Danger Investigation
Authors: Xie Yuwei , Pubucireng  , Wan Yuanwu , Peng Xuehui , Jing Peiran 
Published: November 2024

AbstractThere are numerous cascade reservoirs in China’s small and medium-sized river basins. Once the cascade reservoirs break, the disastrous consequences will result in extreme economic, social, and ecological losses. According to the hidden danger investigation results of cascade reservoirs, a risk assessment method and standard for cascade reservoirs were proposed and established based on the risk matrix method, which provides a foundation for the risk assessment of cascade reservoirs. Taking the D, C, and H cascade reservoirs as the case study, according to the hidden danger investigation results and dam break consequences of the reservoirs, it was concluded that the risk levels of the three reservoirs were in order of extremely high risk, high risk, and high risk. Therefore, it is suggested that engineering and non-engineering measures should be taken to reduce the cascade reservoir’s risk to ensure the high-quality and safe operation of the cascade reservoir group in China.
Study of Discharge Capacity of Curved Weir
Authors: Qiu Peisheng , Zhou Yu , Wang Linjie , Guo Yuan , Ge Tinghui , Wang Dongxue , Xu Minrong , Mao Xin , Zhu Shuxian 
Published: November 2024

AbstractThe curved weir, as an innovative weir design, offers an extended upstream edge compared to orthogonal weirs, enhancing discharge capacity across its width and ensuring river flow safety. However, for rivers of fixed width, the effects of the curved configurations, partically the central angles, on hydraulic performance, warrant further investigation. This research uses FLOW-3D software to numerically simulate curved weir and orthogonal weir with different central angles (120°, 150° and 180°), and comparatively analyses the hydraulic characteristics of the two types of weirs under different upstream head conditions in terms of flow pattern, flow velocity, discharge coefficient and so on. The results show that under the condition of low upstream head, the discharge capacity of curved weir is obviously stronger than that of orthogonal weir, and when the degree of central angle α = 120°, which provides the necessary theoretical basis for the practical popularization of curved weir.
Study on Dynamic Risk Assessment of Urban Flood Based on Improved Genetic Algorithm
Authors: Zhao Mengqi , Wang Zhining , Cen Dandong , Zhang Yaoyi 
Published: November 2024

AbstractStudy on risk assessment of urban flood is the key to ensure the operation safety of city. In existing researches, the dynamic impact factors were not taken into account, and the evaluation method based on heuristic algorithm depends on a large number of training samples. To solve the above deficiencies, dynamic risk assessment of urban flood based on improved genetic algorithm was proposed in this paper. In this assessment index system, disaster-inducing factors, hazard-inducing environment, hazard-affected body, disaster prevention and reduction ability are taken into considered. The dynamic assessment of urban flood risk for small sample is realized by using genetic algorithm improved by date augmentation, also the consistency and superiority of the method are verified by case study. The research results of this paper provide a new idea and a technical mean for the dynamic management of urban flood risk assessment, and have very important value of application and promotion.
Study on Hydrodynamic Load of Permeable Structure for Offshore Oilfield Based on Model Test
Authors: Qin Qing , Qi Jingjing 
Published: November 2024

AbstractIn order to identify the hydrodynamic load of a new type of permeable structure for the offshore oilfield, a physical simulation test is performed using a scale model. The variation of hydrodynamic load parameters of the new permeable structure under different working conditions is compared. The results can provide basic data for optimization of structural parameters of the new permeable structure for offshore oilfields. The relevant experimental results can provide basic data for optimizing the structural parameters of permeable structures in tidal flats, and provide a basis for the engineering design and construction of permeable structures.
Study on Hydraulic Characteristics of Rock Plug Inlet/Outlet Blasting Process in a Power Station
Authors: Yang Shaojia , Wang Yongqing , Zhang Tao 
Published: November 2024

AbstractHydraulic characteristics of rock plug blasting are the key to successful construction of rock plug inlet/outlet. In this paper, the hydraulic characteristics of rock plug blasting at the inlet/outlet of the lower reservoir of a pumped storage power station are studied by means of physical model test. The characteristic laws of water hammer pressure, surge of gate shaft and accumulation effect during blasting are obtained. The results verify the rationality of the design type of rock plug inlet, and demonstrate the feasibility of using gate direct water blocking scheme and high water level blasting during rock plug blasting. The research results can provide technical support for the design and construction of this project, and provide reference for similar projects.
Application of Multi-objective Intelligent Management and Control Platform for Cascade Reservoirs—Case Study on Nam Ou River in Laos
Authors: Li Yang , Zhou Jianxin , Dai Rong , Li Tianqing , Yang Baiyin 
Published: November 2024

AbstractIn the construction and operation of cascaded reservoir groups, higher requirements have been put forward for multi-objective optimization scheduling of cascaded reservoir groups, aiming to promote benefits and eliminate hazards through joint scheduling, leverage comprehensive benefits, ensure basin safety, and meet the needs of digital transformation of hydropower and water conservancy. Based on the research of integrated methods for hydrological forecasting, multi-objective scheduling, and decision-making of basin cascade reservoirs, this study constructs a multi-objective intelligent control system that serves hydrological forecasting, cascade scheduling, flood control, and risk assessment of cascade reservoirs, and applies it to the development of cascade hydropower in the southern European river basin of Laos.
Seismic Safety of a High Geomembrane Faced Soft Rockfill Dam on Overburden Subjected to Strong Earthquake
Authors: Wang Libo , Cen Weijun , Wang Dongliang , Tang Jie 
Published: November 2024

Abstract3D dynamic finite element calculation is carried out for a 161 m high geomembrane faced soft rockfill dam on overburden in a strong earthquake area. The dynamic response of the dam is obtained. The horizontal dynamic displacement is relatively more significant. The maximum vertical permanent deformation and deflection of geomembrane occur at the dam crest near the maximum dam cross section. The tensile strain of geomembrane increases significantly at the dig-fill junction and the reverse arc section. The maximum tensile strain of geomembrane is 1.52%, and the safety factor of geomembrane tensile strain is greater than the allowable value. Even subjected to the strong earthquake, the geomembrane slab can effectively coordinate the deformation with the dam body and deep overburden and the dam can be in a safe operation state.
In-medium gluon radiation spectrum with all-order resummation of multiple scatterings in longitudinally evolving media
Authors: Andres Carlota , Apolinário Liliana , Dominguez Fabio , Martinez Marcos Gonzalez 
Published: November 2024

Abstract
Over the past years, there has been a sustained effort to systematically enhance our understanding of medium-induced emissions occurring in the quark-gluon plasma, driven by the ultimate goal of advancing our comprehension of jet quenching phenomena. To ensure meaningful comparisons between these new calculations and experimental data, it becomes crucial to model the interplay between the radiation process and the evolution of the medium parameters, typically described by a hydrodynamical simulation. This step presents particular challenges when dealing with calculations involving the resummation of multiple scatterings, which have been shown to be necessary for achieving an accurate description of the in-medium emission process. In this paper, we extend our numerical calculations of the fully-resummed gluon spectrum to account for longitudinally expanding media. This new implementation allows us to quantitatively assess the accuracy of previously proposed scaling laws that establish a correspondence between an expanding medium and a “static equivalent”. Additionally, we show that such scaling laws yield significantly improved results when the static reference case is replaced by an expanding medium with the temperature following a simple power-law decay. Such correspondence will enable the application of numerical calculations of medium-induced energy loss in realistic evolving media for a broader range of phenomenological studies.
Electroweak corrections to Higgs boson pair production: the top-Yukawa and self-coupling contributions
Authors: Heinrich G. , Jones S. P. , Kerner M. , Stone T. W. , Vestner A. 
Published: November 2024

Abstract
We present results for the Yukawa-enhanced and Higgs self-coupling type electroweak corrections to di-Higgs production in gluon fusion. The calculation of the corresponding four-scale, two-loop amplitude is carried out retaining the exact symbolic dependence on all masses and scales during the reduction to master integrals. The resulting integrals are then evaluated at high precision using both the series expansion of the differential equations and sector decomposition. Differential cross sections for the di-Higgs invariant mass and the transverse momentum of a Higgs boson are shown, where we find that the corrections are most pronounced at low invariant mass and transverse momentum.
The human biological advantage over AI
Authors: Stewart William 
Published: November 2024

AbstractRecent advances in AI raise the possibility that AI systems will one day be able to do anything humans can do, only better. If artificial general intelligence (AGI) is achieved, AI systems may be able to understand, reason, problem solve, create, and evolve at a level and speed that humans will increasingly be unable to match, or even understand. These possibilities raise a natural question as to whether AI will eventually become superior to humans, a successor “digital species”, with a rightful claim to assume leadership of the universe. However, a deeper consideration suggests the overlooked differentiator between human beings and AI is not the brain, but the central nervous system (CNS), providing us with an immersive integration with physical reality. It is our CNS that enables us to experience emotion including pain, joy, suffering, and love, and therefore to fully appreciate the consequences of our actions on the world around us. And that emotional understanding of the consequences of our actions is what is required to be able to develop sustainable ethical systems, and so be fully qualified to be the leaders of the universe. A CNS cannot be manufactured or simulated; it must be grown as a biological construct. And so, even the development of consciousness will not be sufficient to make AI systems superior to humans. AI systems may become more capable than humans on almost every measure and transform our society. However, the best foundation for leadership of our universe will always be DNA, not silicon.
Democratizing AI in public administration: improving equity through maximum feasible participation
Authors: Taylor Randon R. , Murphy John W. , Hoston William T. , Senkaiahliyan Senthujan 
Published: November 2024

AbstractIn an era defined by the global surge in the adoption of AI-enabled technologies within public administration, the promises of efficiency and progress are being overshadowed by instances of deepening social inequality, particularly among vulnerable populations. To address this issue, we argue that democratizing AI is a pivotal step toward fostering trust, equity, and fairness within our societies. This article navigates the existing debates surrounding AI democratization but also endeavors to revive and adapt the historical social justice framework, maximum feasible participation, for contemporary participatory applications in deploying AI-enabled technologies in public administration. In our exploration of the multifaceted dimensions of AI’s impact on public administration, we provide a roadmap that can lead beyond rhetoric to practical solutions in the integration of AI in public administration.
Predictive Factors for Clean Intermittent Catheterization after Intravesical OnabotulinumtoxinA Injections in Women with Overactive Bladder: a Danish Retrospective Cohort Study
Authors: El Issaoui Meryam , Elissaoui Sophia , Elmelund Marlene , Klarskov Niels 
Published: November 2024

Abstract

Introduction and Hypothesis
We aimed to evaluate the clean intermittent catheterization (CIC) rate in women undergoing their first OnabotulinumtoxinA (BTX-A) treatment and to investigate factors predictive of initiating CIC.

Methods
This was a retrospective cohort of women, who had their first BTX-A treatment for symptoms of overactive bladder (OAB) syndrome, with a pretreatment urodynamic study (UDS). We reviewed demographic, medical and gynecological history, UDS, pretreatment bladder diaries, objective examinations, BTX-A treatment details, and post-void residual (PVR) reports in the electronic medical record. Botox® Allergan 100 International Units were injected into the detrusor at 10–20 sites. Statistical analyses included univariate and multivariate logistic regression analyses.

Results
We included 397 women. Median age was 68 (Q1–Q3: 54–76) years. CIC rate was 8.6% (n = 34) following the first BTX-A treatment. Urgency urinary incontinence (UUI) reduced the risk of undergoing CIC (OR 0.30, 95% CI 0.09–0.97). A bladder capacity of 500 ml or greater in the bladder diary increased the risk of CIC (OR 2.46, 95% CI 1.06–5.70), whereas reported leakages were associated with a decreased risk of CIC (OR 0.24, 95% CI 0.10–0.57). Multivariate logistic regression analysis showed that anterior colporrhaphy (OR 3.71, 95% CI 1.52–9.06) and 10-ml increments in median maximum cystometric capacity (OR 1.03, 95% CI 1.00–1.06) predicted CIC, whereas UUI was a protective factor for CIC (OR 0.23, 95% CI 0.07–0.79).

Conclusions
A history of anterior colporrhaphy, large bladder capacity, and absence of incontinence episodes in bladder diary or UDS were risk factors for CIC after the first BTX-A treatment.