bluuebunny/crossref_metadata_2025_split huggingface dataset:
Body mass index and lifetime healthcare utilization
Authors: Edwards Christina Hansen , Aas Eline , Kinge Jonas Minet 
Published: October 2019

Abstract
Background: Overweight and obesity is a major global public health challenge, and understanding the implications for healthcare systems is essential for policy planning. Past studies have typically found positive associations between obesity and healthcare utilization, but these studies have not taken into consideration that obesity is also associated with early mortality. We examined associations between body mass index (BMI, reported as kg/m2) and healthcare utilization with and without taking BMI-specific survival into consideration. Methods: We used nationally representative data on 33 882 adults collected between 2002 and 2015. We computed BMI- and age-specific primary and secondary care utilization and multiplied the estimated values with gender-, age-, and BMI-specific probabilities of surviving to each age. Then, we summed the average BMI-specific utilization between 18 and 85 years. Results: During a survival-adjusted lifetime, males with normal weight (BMI: 18.5–24.9) had, on average, 167 primary care, and 77 secondary care contacts. In comparison, males with overweight (BMI: 25.0–29.9), category I obesity (BMI: 30.0–34.9), and category II/III obesity (BMI ≥35.0) had 11%, 41%, and 102% more primary care, and 14%, 29%, and 78% more secondary care contacts, respectively. Females with normal weight had, on average, 210 primary care contacts and 91 secondary care contacts. Females with overweight, category I obesity, and category II/III obesity had 20%, 34%, and 81% more primary care contacts, and 26%, 16%, and 16% more secondary care contacts, respectively. Conclusion: The positive association between BMI and healthcare utilization was reduced, but not offset, when BMI-specific survival was taken into consideration. Our findings underpin previous research and suggest that interventions to offset the increasing prevalence of overweight, and especially obesity, are warranted.
Whole genome analysis of Black Bengal goat from Savar Goat Farm, Bangladesh
Authors: Chowdhury Ziqrul Haq , Hussain Nazmul , Hasan Saam , Kabir Ajran , Mahmud Muket , Robbani Mahdi , Tabassum Tahmina , Afroze Tamanna , Rahman Aura , Islam Rafiqul , Hossain Maqsud 
Published: October 2019

Abstract
Objectives:
Single Nucleotide Polymorphisms (SNPs) play critical roles in genetic diversity and disease. Many traits and diseases are linked with exonic SNPs that are significant for gene function, regulation or translation. This study focuses on SNPs that potentially act as the genetic basis for desirable traits in the Black Bengal Goat. This variety of goat is native to South Asia, and is identified as one of the most commercially important meat producing animals in the world. The aim of this study was to sequence the genome of Black Bengal Goats and identify SNPs that might play a significant role in determining meat quality in the organism. The study focuses on exonic SNPs for their greater likelihood of affecting the final translated protein product.
Results:
Approximately 76,000 exonic variants were identified in the study. After filtration using a Wilcoxon test based score, the number came down to 49, 965 which were found to be distributed in 11,568 genes. The functional pathways affected by these variations included fatty acid metabolism and degradation, which are important processes that influence meat quality.
The effects of aerobic exercises on high sensitivity C-reactive protein and depression in patients living with HIV infection; a systematic review with meta-analysis
Authors: Anieto Ebuka Miracle , Uduonu Ekezie Mmanwanne , Ezeukwu Obinna Antoninus , Abaraogu Ukachukwu Okoroafor , Nwadilibe Ijeoma Blessing , Adu Omotoyosi Johnson , Kalu Michael Ebe 
Published: October 2019

Abstract
Background

HIV infection and chronic use of highly active antiretroviral therapy have been associated with increased expression of pro-inflammatory biomarkers (e.g. high-sensitivity C-reactive protein) and major affective disorders (e.g. depression). There is a growing research interest in aerobic exercise as an adjunct therapy on inflammatory outcomes and depression in people living with HIV (PLHIV) who are undergoing antiretroviral therapy. Synthesizing and appraising available evidence may be essential to guide practice and future research on exercise intervention to this population. This review evaluated the effects of aerobic exercises on serum levels of high-sensitivity C-reactive protein (hs-CRP) and depressive symptoms in PLHIV.

Methods

Cochrane Central Register of Controlled Trials, MEDLINE, PEDRO, EMBASE, AMED, CINAHL, and Web of Science were systematically searched to include clinical trials that investigated the effects of aerobic exercises on hs-CRP and/or depression in PLWH. Two reviewers independently screened all the articles for eligibility and also evaluated the risk of bias using the Cochrane Collaboration risk of bias assessment tool. Data were extracted and meta-analyses conducted using Review Manager Software.

Results

Six studies (261 participants) met the inclusion criteria and were included in the review. Four of the studies reported on depressive symptoms and two on hs-CRP outcome The meta-analysis result showed a significant (Z=3.78, p<0.0002) decrease in depression scores in PLWH; implying that aerobic exercise interventions reduce depressive symptoms among PLWH. The two studies that reported on hs-CRP outcome, found no significant effect of aerobic exercise on hs-CRP. Overall, the GRADE evidence for this review was of moderate quality.

Conclusion

There was evidence that aerobic exercises of about 24-60 minutes duration, two to five times per week can lead to a significant improvement in depression level but not hs-CRP in PLWH. However, it should not be concluded as ‘no evidence of effect’ because the included trials do not have sufficient power to detect treatment effects. Thus, further homogenous research with enough “power” is necessary for a conclusive estimate of effects.
Correlation Between Ischaemia Modified Albumin Level And Coronary Collateral Circulation
Authors: Chen Xin , Lin Yan , Tian Lihua , Wang Zhiquan 
Published: October 2019

Abstract
Abstract
Objective: To investigate the correlation between ischaemia modified albumin(IMA) level and coronary collateral circulation(CCC) in patients with chronic total occlusive disease(CTO).Methods: Coronary angiography was performed in the Department of Cardiology, Zhongnan Hospital of Wuhan University from 2017-08 to 2019-02 to determine 128 patients with CTO lesions in at least one major coronary artery.According to the Rentrop evaluation criteria,the degree of CCC formation was divided into CCC poor formation group (Rentrop0-1grade,n=69)and CCC formation good group(Rentrop2-3grade,n=59).The IMA level of the patients was measured using an albumin-cobalt binding assay.Record and analyze the patient's general data, blood routine,total bilirubin(TBIL),blood lipids,uric acid (UA),left ventricular ejection fraction(LVEF) and other indicators,while recording the patient's occlusion of blood vessels.Results: The proportion of platelet count and diabetes in the poor CCC group was higher than that in the good group (P<0.05).The ratio of ischemic modified albumin and total bilirubin in the poor CCC group was lower than that in the good group (P<0.05).Multivariate logistic regression analysis showed that ischemic modified albumin was positively correlated with CCC formation[OR=1.190,95%CI(1.092-1.297),P<0.001],diabetes was negatively correlated with CCC formation[OR=0.285,95%CI(0.094-0.864),P<0.05].Ischemic modified albumin predicts good formation of CCC under the ROC curve and the area under the ROC curve is 0.769(95%CI:0.686-0.851，P＜0.001);the optimal cut-off value was 63.35KU/L,the sensitivity is 71.2%,specificity is 71%.Conclusion: The IMA level is closely related to the good formation of CCC.The higher IMA level can be used as an effective predictor of the good CCC formation in CTO.
Comparative Analysis of the Effects of Propofol and Sevoflurane on Postoperative Cognitive Function in Elderly Patients with Lung Cancer
Authors: Sun Haitao , Zhang Guohua , Ai Bolun , Zhang Huimin , kong xiangyi , Lee Wan-Ting , Yan Tao , Zheng Hui , Sun Li 
Published: October 2019

Abstract
Background The potential risk for cognitive impairment following surgery and anesthesia is a common concern, especially in the elderly and more fragile patient. The risk for various neurocognitive effects is thus an area of importance. The independent impact of surgery and anesthesia is still not known. Likewise, the independent effect of different drugs used during anesthesia is a matter of debate as is the number and amounts of drugs used and the "depth of anesthesia". So, understanding the drug-related phenomenon and mechanisms for postoperative cognitive impairment is essential. This meta-analysis aims to compare the effects of propofol and sevoflurane anesthesia on postoperative cognitive function in elderly patients with lung cancer.
Methods This study is a meta-analysis for controlled-clinical-studies. Public-available online databases were searched to identify eligible randomized placebo-controlled trials or prospective cohort studies concerning the effects of propofol and sevoflurane on postoperative cognitive function. The primary endpoints are postoperative mini-mental state examination (MMSE) scores at various time points; the secondary endpoint is the serum S100beta concentration 24 hours after surgery. Standard mean differences (SMDs) along with 95% confidence intervals (CIs) were extracted and analyzed using random or fixed effects models. Analyses regarding heterogeneity, risk of bias assessment, and sensitivity were performed.
Results We searched 1626 eligible publications and 14 studies of 1404 patients were included in the final analysis. The majority of included studies had been undertaken in Asian populations. Results suggested that propofol has a greater adverse effect on cognitive function in the elderly patients with lung cancer than sevoflurane. There were significant differences in issues of MMSE 6h (11 studies; SMD -1.391, 95% CI -2.024, -0.757; p < 0.001), MMSE 24h (14 studies; SMD -1.106, 95% CI -1.588, -0.624; p < 0.001), MMSE 3d (11 studies; SMD -1.065, 95% CI -1.564, -0.566; p < 0.001), MMSE 7d (10 studies; SMD -0.422, 95% CI -0.549, -0.295; p < 0.001), and serum S100beta concentration at 1 day after surgery (13 studies; SMD 0.746, 95% CI 0.475, 1.017; p < 0.001).
Conclusion Propofol has a more significant adverse effect on postoperative cognitive function in elderly patients with lung cancer than sevoflurane.
Association between anemia and frailty in 13,175 community-dwelling adults aged 50 years and older in China
Authors: Ruan Ye , Guo Yanfei , Kowal Paul , Lu Ye , Liu Chazhen , Sun Shuangyuan , Huang Zhezhou , Zheng Yang , Wang Wenjing , Li Gan , Shi Yan , Wu Fan 
Published: October 2019

Abstract
Background: Anemia and frailty contribute to poor health outcomes in older adults; however, most current research in lower income countries has concentrated on anemia or frailty alone rather than in combination. The aim of the present study was to investigate the association between anemia and frailty in community-dwelling adults aged 50 years and older in China.
Methods: The study population was sourced from the 2007/10 SAGE China Wave 1. Anemia was defined as hemoglobin less than 13g/dL for men and less than 12g/dL for women. A frailty index (FI) was compiled to assess frailty. The association between anemia and frailty was evaluated using a 2-level hierarchical logistic model.
Results: The prevalence of anemia was 31.0% (95%CI: 28.4%, 33.8%) and frailty 14.7% (95%CI: 13.5%, 16.0%). In the univariate regression model, presence of anemia was significantly associated with frailty (OR=1.62, 95% CI: 1.39, 1.90) and the effect remained consistent after adjusting for various potential confounding factors including age, gender, residence, education, household wealth, fruit and vegetable intake, tobacco use, alcohol comsumption and physical activity (adjusted OR =1.31, 95% CI:1.09, 1.57). In the linear model, each 1 g/dL increase in hemoglobin concentration was associated with 4% decrease in the odds of frailty after adjusting for several confounding variables (adjusted OR =0.96, 95% CI: 0.93, 0.99).
Conclusion: Anemia and low hemoglobin concentrations were significantly associated with frailty. Therefore, health care professionals caring for older adults should increase screening, assessment of causes and treatment of anemia as one method of avoiding, delaying or even reversing frailty.
The impact of an orthogeriatric intervention in patients with fragility fractures: A cohort study
Authors: Abrahamsen Charlotte , Nørgaard Birgitte , Draborg Eva , Nielsen Morten Frost 
Published: October 2019

Abstract
Background:
While orthogeriatric care to patients with hip fractures is established, the impact of similar intervention in patients with fragility fractures in general is lacking. Therefore, we aimed to assess the impact of an orthogeriatric intervention on postoperative complications and readmissions among patients admitted due to and surgically treated for fragility fractures.
Methods:
A prospective observational cohort study with a retrospective control was designed. A new orthogeriatric unit for acute patients of sixty-five years or older with fragility fractures in terms of hip, vertebral or appendicular fractures was opened on March 1, 2014. Patients were excluded if the fracture was cancer-related or caused by high-energy trauma, if the patient was operated on at another hospital, treated conservatively with no operation, or had been readmitted within the last month due to fracture-related complications.
Results:
We included 591 patients; 170 in the historical cohort and 421 in the orthogeriatric cohort. No significant differences were found between the two cohorts with regard to the proportion of participants experiencing complications (24.5% versus 28.3%, p = 0.36) or readmission within 30 days after discharge (14.1% vs 12.1%, p = 0.5). With both cohorts collapsed and adjusting for age, gender and CCI, the odds of having postoperative complications as a hip fracture patient was 4.45, compared to patients with an appendicular fracture (p < 0.001). Furthermore, patients with complications during admission were at a higher risk of readmission within 30 days than were patients without complications (22.3% vs 9.5%; p < 0.001).
Conclusions:
In older patients admitted with fragility fractures, our model of orthogeriatric care showed no significant differences regarding postoperative complications or readmissions compared to the traditional care. However, we found significantly higher odds of having postoperative complications among patients admitted with a hip fracture compared to other fragility fractures. Additionally, our study reveals an increased risk of being readmitted within 30 days for patients with postoperative complications.
Knowledge, Attitude and Practices toward Chronic Kidney Disease among care providers in Jimma Town: Cross-sectional study
Authors: Wolide Amare Desalegn , Goro Kabaye Kumele , Dibaba Fantu Kerga , Debalke Serkadis , Seboka Meskerem , Tufa Birtukan Edilu , Fufa Fanta Gashe , Bobasa Eshetu Mulisa 
Published: October 2019

Abstract
Introduction: Chronic kidney disease (CKD) is a common and growing health problem that requires adequate knowledge by health care providers to reduce the progress of the diseases. Thus, this study is aimed to assess the care provider’s knowledge, attitude, and practices toward CKD.Method: Cross-sectional study was conducted among 326 care providers at Jimma University Specialized hospital and three medium to higher clinics found in Jimma Town. Collected data entered to Epi-Data version 3.1 and exported to SPSS version 21 for windows for data analysis. Descriptive statistics and generalized linear modal were used to analyze the data.Result: The mean age and service year of the participants were 29.68(±4.877) and 4.28(±4.561), respectively. The overall weighted knowledge, attitude and practice score of the study participant was 9.0971(8.77, 9.42), 2.53(2.4,2.65), 10.14(9.94,10.33) respectively. Over half of the care providers had the awareness to use eGFR to assess kidney function and patient referral to nephrologist respectively. Also, many care providers knew the five-stage of CKD and the risk factors of CKD such as diabetes, long term alcohol consumption, and anemia and cardiovascular disorders respectively. Care providers had an understanding of late detection and referral of CKD would increase kidney disease complication. Besides, 275(84.4 %) of them are worried about treatment cost related to CKD. Over half of the care providers, 238(73.0%) believed that the Ethiopian ministry of health gave less attention to the problem. Furthermore, 234(71.8%) are interested to study more on CKD management. Majority 256(78.5%), very likely or likely refer patient to senior physician and Nephrologist.Conclusion: Care provides knowledge was found to be above moderate level and many had the knowledge on the basic function of the kidney, risk factors, treatment, and management of CKD. Many are worried about treatment cost and interested to learn about CKD primary from textbook and internet. The majority had a practice of referring patients to nephrologists or a senior physician. Many care providers had a frequent discussion on the prevention strategies of CKD.
The relationship of depression and anxiety among diabetic patients with changes in the components of lipid profile
Authors: Abdelfattah Diaa , Alduraywish Abdulrahman 
Published: October 2019

Abstract
Introduction our study aimed to investigate the presence of depression and anxiety symptoms in diabetic patients and their association with various components of lipid profile.Methods 428 patients with diabetes mellitus joined our study. Their de- mographic and lipid profile measurements were collected. The screening questionnaire HADS was used to evaluate level of depression and anxiety. An age matched control group consisting of 50 individuals were taken and their lipid profiles and depression and anxiety levels were determined.Results it was found that 22.4% of the sample showed marked depressive symptoms and 28.5% showed marked anxiety symptoms. We found that: depression was associated strongly but not significantly (P=0.057) with lower high density lipoproteins, and associated significantly (P=0.036) with lower total cholesterol level. In addition, anxiety was associated significantly (0.000) with lower high density lipoproteins and was associated significantly (P=0.004) with higher triglycerides level. There was insignificant association between all components of lipid profile and either depression or anxiety levels in the control group.Conclusion Depressive and anxiety symptoms were common among diabetic patients. Depression was related to lower high density lipoproteins, and to lower total cholesterol level. Anxiety was strongly related to lower high density lipoproteins and to higher triglycerides level. This relationship was specific to patients with diabetes mellitus in our study .
Effects of weight- and age-related syndesmophytes on patients with ankylosing spondylitis.
Authors: Dong Chen , Wang Jing , Zhao Rui , Ji Juan , Chen Yuanyuan , Fu Ting , Gu Zhifeng 
Published: October 2019

Abstract
Objective: To determine contributors of syndesmophytes and evaluate their effects on various aspects of quality of life among patients with ankylosing spondylitis (AS). Methods: we conducted a cross-sectional study and 85 AS patients received the X-ray examination and completed the questionnaire including demographic variables, clinical variables, psychological variables and quality of life. Results: There were 44(51.8%) with syndesmophytes among AS patients. Age, gender, body mass index (BMI), waist hip ratio (WHR), education level, disease duration and the level of ESR were different between AS patients with or without syndesmophytes. AS patients with syndesmophytes have more problems in functional status, spinal mobility, night or global pain, disability and health related quality of life. Conclusions: Syndesmophytes had negative effects on AS patients in the field of functional status, spinal mobility, pain, disability and quality of life. In addition, aging, gender, WHR was the key predictor of syndesmophytes formation.
Large Difference between Proximal Junctional Angle and Rod Contouring Angle is a Risk Factor for Proximal Junctional Kyphosis
Authors: Wang Jie , Yang Ningning , Luo Ming , Li Ning , Fan Yonggang , Xia Lei 
Published: October 2019

Abstract
Background: There are several risk factors for proximal junctional kyphosis (PJK) in adolescent idiopathic scoliosis (AIS) surgery. Decreased rod contouring angle (RCA) has been proposed as a risk factor for PJK, but the role of difference between proximal junctional angle (PJA) and RCA (PJA-RCA) has not been fully investigated. The aim of this study was to assess the role of PJA-RCA for the development of postoperative PJK in AIS. Methods: We performed a retrospective analysis of 96 AIS patients who underwent posterior segmental spinal instrumentation and fusion between the years 2012 and 2018 (minimum 1.5-year and average 2-year follow-up) at a single institution. Each patient was measured on preoperative, postoperative and final follow-up long-cassette standing radiographs. The PJA-RCA was regarded as a new definition that reflects the match degree between proximal rod contouring and vertebra curvature, and radiographic parameters were compared between PJK and non-PJK group. Results : Among the 96 patients with a mean age of 14.00 years (± 0.82), the overall incidence of PJK was 22%. PJK group showed a significantly greater preoperative SVA (P = 0.032) and larger correction of SVA (P = 0.007) than non-PJK group. At the last follow-up, PJK patients had significantly greater LL (P = 0.046). Patients in the PJK group had significantly greater preoperative PJA-RCA than the non-PJK group (4.07±3.30 vs. 1.42±4.28, P = 0.024). However, RCA was not significantly different between two groups (3.88 ± 4.34 vs. 2.86 ± 3.36, P = 0.405). In addition, Pearson correlation coefficient showed a significant correlation between the change of SVA and the last follow-up PJA (r = -0.208, P = 0.042). Preoperative PJA-RCA and postoperative PJA-RCA demonstrated similar results which showed a strong correlation with the last follow-up PJA (r = 0.528 and r = 0.532 respectively, P < 0.000). Conclusions: As a new reflex of improper rod contouring, large PJA-RCA is a risk factor for PJK in AIS, and PJK might be a compensation mechanism rather than complication when spine is shifted and overcorrected. Keywords: adolescent idiopathic scoliosis, proximal junctional kyphosis, proximal junctional angle, rod contouring angle.