bluuebunny/crossref_metadata_2025_split huggingface dataset:
Not so positive, please!
Authors: Hernandez-Ortega Blanca 
Published: January 2019

Purpose
The purpose of this paper is to analyse the effect of positive online consumer reviews (OCRs) on changes in the individual’s evaluations from the pre-purchase to the post-consumption stage, studying satisfaction, attitude towards the firm and purchase intention. The effect of positive OCRs may differ depending on whether the product performance is high or low, i.e., whether the product meets the objectives of the consumer. So, the paper also explores different effects that positive OCRs can have on changes in the individual’s evaluations depending on the kind of performance.

Design/methodology/approach
Two studies based on the experimental methodology are carried out and several statistical techniques are applied: confirmatory factorial analysis, mixed between-within subjects analysis of variance and post-hoc analysis.

Findings
Results demonstrate that the effect of positive OCRs continues after consumption. Depending on the performance, this effect can be positive (negative) and verify (contrast with) the individual’s pre-purchase evaluations. Moreover, this effect is always more intense when the performance is low.

Originality/value
It explores the changes in the individual’s evaluations about the product and the firm, going beyond the immediate effect of positive OCRs. It also explains the effects of positive OCRs for high and low performance. Finally, it demonstrates that OCR effects are not symmetrical for high and low performance.
Identifying the characteristics of a high-performance finance function
Authors: de Waal André , Bilstra Eelco , De Roeck Peter 
Published: January 2019

Purpose
The concept of the high-performance organization (HPO) receives much attention nowadays. To create and sustain an HPO, all parts of the organization must contribute, especially the finance function, whose relations with every part of the organization mean that it can be regarded as the spider in the organizational web. The paper aims to discuss this issue.

Design/methodology/approach
This study develops the high-performance finance function (HPFF) framework based on the HPO framework, a scientifically developed and validated approach to transforming organizations into HPOs. Based on an extensive literature review, potential characteristics of an HPFF were identified and subsequently linked to factors in the HPO framework. Subsequently, using a questionnaire and statistical analysis, these potential characteristics were clustered into five HPFF factors that showed a significant positive relation with the finance function’s performance.

Findings
The five HPFF factors are: Finance Function Improvement, IT Focus, People Development (of financial professionals working in the function), Role Clarity (for each of the various types of role in the function) and Strategic Role (of the finance function in the organization, especially in supporting management).

Originality/value
The HPFF framework is a practical improvement framework based on a solid scientific foundation. It also fills the current gap in the academic literature on how to develop HPFFs, thus giving the frameworks described in practitioner literature a robust scientific grounding.
The impact of technological and non-technological innovations on export intensity in SMEs
Authors: Radicic Dragana , Djalilov Khurshid 
Published: January 2019

Purpose
The purpose of this paper is to investigate how both technological and non-technological innovations influence export intensity in small and medium-sized enterprises (SMEs). In addition, the authors report results for each firm-size category of micro-, small and medium firms, and thus reflect SME heterogeneity.

Design/methodology/approach
The research methodology is based on the analysis of the Eurobarometer 2014 data set from 28 EU Member States, Switzerland and the USA covering the period 2011–2014. To statistically test the three defined research hypotheses on individual and joint effects of both types of innovation, a multiple treatment model was estimated. The advantage of this empirical strategy is that it takes into account the endogeneity of both technological and non-technological innovations. Moreover, the authors employ the production approach or the direct test of complementarity between technological and non-technological innovations.

Findings
Empirical findings indicate that technological innovations positively affect export intensity in small and medium firms, whereas non-technological innovations exert no influence on export intensity, regardless of the firm size. Moreover, the results from the direct test suggest no evidence of the complementary effects of technological and non-technological innovation on export intensity.

Research limitations/implications
The authors infer that SMEs would benefit more from public support targeting both exports and innovations than micro-firms, as the sunk costs of exports are too high for the latter. However, public support aimed at reducing fixed costs of exports could be particularly beneficial for micro-firms.

Originality/value
The research fills a literature gap on the joint impact of technological and non-technological innovations on export intensity while taking into account the endogeneity of innovation activities and SME heterogeneity.
Validation of the Systemic Clinical Outcome and Routine Evaluation (SCORE‐15) self‐report questionnaire: index of family functioning and change in Swedish families
Authors: Zetterqvist M. , Hånell H. Erneroth , Wadsby M. , Cocozza M. , Gustafsson P. A. 
Published: January 2019

Instruments for evaluating the progress and outcome of systemic therapeutic treatments in clinical practice need to be easily administered and have sound psychometric properties. The Systemic Clinical Outcome and Routine Evaluation, 15‐item version (SCORE‐15), is a self‐report instrument that measures aspects of family functioning. This study investigates the psychometric qualities of a Swedish version of SCORE‐15. Seventy Swedish families with healthy children and 159 families with children with psychiatric or behavioural problems were included in the study, resulting in a total of 397 individuals. Results showed that SCORE‐15 differentiated clinical from non‐clinical families with acceptable psychometric properties for test‐retest, internal consistency, convergent and construct validity, as well as sensitivity to change for the clinical sample. The three‐factor solution of strengths, difficulties and communication was tested. Results imply preliminary psychometric support for the use of the Swedish version of SCORE‐15 to evaluate progress and outcome in clinical practice.Practitioner points

SCORE‐15 is an easily administered questionnaire suitable for use in clinical practice to evaluate systemic therapeutic progress and outcome

The Swedish version of SCORE‐15 has acceptable psychometric properties
Communication‐mediated psychological mechanisms of Chinese publics’ post‐crisis corporate associations and government associations
Authors: Ji Yingru , Kim Sora 
Published: January 2019

AbstractThrough an online national survey in China, the study empirically examines the serial mediation effects of active communication behaviour and post‐crisis corporate associations in the relationships between initial crisis perceptions of problem, constraint, and involvement recognitions and government associations. The study suggested that higher problem and involvement recognitions were positively associated with more active communication behaviour in crisis, and such active communication behaviour was in turn positively associated with more favourable post‐crisis corporate associations. The findings also revealed connections between post‐crisis corporate associations and government associations, suggesting publics’ psychological associations of the company in crisis were extended to government associations in China.
Specification and negotiation in incomplete contracts
Authors: An Yonghong , Tang Xun 
Published: January 2019

AbstractWe investigate contractors' bargaining power and holdup on buyers in procurement auctions of incomplete contracts held by California Department of Transportation. Using a model where contractors bid competitively in response to a buyer's choice of initial contract design, we infer the contractors' costs and bargaining power from the bids and transfers negotiated after the auction. We find that the contract winners have substantial bargaining power in post‐auction negotiation. The average holdup on the buyer is about 20% of project costs. Counterfactual cost‐plus contracts would reduce the buyer's surplus in 72% of the projects, with an average reduction over $382,000.
Patent pools, vertical integration, and downstream competition
Authors: Reisinger Markus , Tarantino Emanuele 
Published: January 2019

AbstractPatent pools are commonly used to license technologies to manufacturers. Whereas previous studies focused on manufacturers active in independent markets, we analyze pools licensing to competing manufacturers, allowing for multiple licensors and nonlinear tariffs. We find that the impact of pools on welfare depends on the industry structure: whereas they are procompetitive when no manufacturer is integrated with a licensor, the presence of vertically integrated manufacturers triggers a novel trade‐off between horizontal and vertical price coordination. Specifically, pools are anticompetitive if the share of integrated firms is large, procompetitive otherwise. We then formulate information‐free policies to screen anticompetitive pools.
Communication between the distal interphalangeal joint and the navicular bursa in the horse at Computed Tomography Arthrography
Authors: Hontoir Fanny , Rejas Erika , Falticeanu Ana , Nisolle Jean‐François , Simon Vincent , Nicaise Charles , Clegg Peter D. , Vandeweerd Jean‐Michel E. 
Published: January 2019

AbstractDiffusion of drugs injected into the distal interphalangeal joint or the navicular (podotrochlear) bursa can influence diagnosis and treatment of foot pain. Previous anatomical and radiographic studies of the communication between these synovial structures have produced conflicting results and did not identify the location of any communication if present. This anatomic study aimed to assess the presence and site of communication between the distal interphalangeal joint and the navicular bursa in the horse by computed tomography arthrography. Sixty‐six pairs of cadaver forelimbs were injected with contrast medium into the distal interphalangeal joint and imaged by computed tomography arthrography. The presence of a communication, location of the communication and additional structural changes were assessed. Navicular bursa opacification occurred in 7 distal limbs (5.3%) following distal interphalangeal joint injection. One limb showed a communication through the T‐ligament and 6 limbs showed a communication through the distal sesamoidean impar ligament. In 3 cases, the communication through the distal sesamoidean impar ligament was associated with a distal border fragment. Our study showed that communication between the distal interphalangeal joint and navicular bursa is uncommon and inconsistent. Clinically, the presence of a communication could (1) influence the interpretation of diagnostic analgesia of the distal interphalangeal joint or the navicular bursa by facilitating the diffusion of local anaesthetic between these structures; (2) allow the drug and its potential adverse effects to spread from the treated synovial cavity to the non‐targeted synovial cavity; (3) be responsible for the failure of joint drainage in the case of sepsis.
The value of magnetic resonance imaging in esophageal carcinoma: Tool or toy?
Authors: Zhu Ying , Fu Lei , Jing Wang , Guo Dong , Chen Yan , Kong Li , Yu Jinming 
Published: January 2019

AbstractCurrently, the use of magnetic resonance imaging (MRI) in patients with esophageal carcinoma is limited. However, the quality of MRI for esophageal carcinoma continues to improve and the importance of MRI in patients with esophageal carcinoma has been gradually recognized. Compared with endoscopic ultrasound and computed tomography applied in T and N staging, MRI has now achieved excellent results after the imaging technique has been optimized. We review the literature on MRI and discuss the future of MRI in esophageal carcinoma. While the role of MRI in staging, tumor volume target delineation and evaluation for preoperative chemoradiotherapy, prognosis and recurrence is still evolving. The application of MRI in esophageal carcinoma has a bright future and potential to improve precision of T and N staging as well as treatment delivery.
Crossing Bodily, Social, and Intimate Boundaries: How Class, Ethnic, and Gender Differences Are Reproduced in Medical Training in Mexico
Authors: Smith‐Oka Vania , Marshalla Megan K. 
Published: January 2019

ABSTRACTBodies are useful instruments for understanding the reproduction of inequalities. In this article, we investigate why and how bodily, social, intimate, and physical boundaries are crossed and what this can tell us about individual and social bodies. We unpack how seeing and being seen, touching and being touched, or feeling and being felt are conditioned in very particular ways by the broader political economy. Participants in this ethnographic research in Mexico used the term manitas to describe how they trained their senses (hands, ears, eyes) during medical practice; how they learned through practice on the bodies of less‐agentive populations (female, raced, or impoverished); and how they crossed intimacy, structural, and physical boundaries through what we term somatic translation: seeing others’ bodies with their own. Manitas was developed unconsciously by doctors, never explicitly taught or learned in practice, reproducing social difference. These forms of learning highlight a friction between the violence of knowing and the importance of touch as a legitimate mode of care. This form of tactile and sensorial learning entails not only a form of boundary crossing that is medically useful, but it is also a form of boundary crossing that surfaces social inequalities by taking advantage of them. [hospital ethnography, anthropology of reproduction, embodiment, social boundaries, Mexico]
Modulation of complement-mediated immune damage by intravenous immune globulin
Authors: Basta M 
Published: January 2019

SummaryHigh-dose intravenous immune globulin (IVIG) exerts a beneficial effect in a variety of immune disorders. One possible underlying mechanism of this effect could be interference with the complement system. This conclusion was based on the results obtained in animal models of complement-mediated pathology, in vitro complement assays and studies on related human diseases. Clearance of IgM-sensitized erythrocytes was specifically suppressed hy IVIG treatment. The same therapy prevented pulmonary endothelial cell lesions, the hallmark of Forssman shock, in 75% of animals. All control animals, either untreated or injected with control reagents, died within minutes following induction of Forssman shock. In vitro uptake of C3b and C4b complement fragments on to corpusculate immune complexes was significantly inhibited by IVIG. Studies that involved patients suffering from disorders with pathogenesis similar to animal models of complement-mediated immune injury fully supported the hypothesis that IVIG interacts with activated complement components and prevents their deposition on target cells. The author’s results suggest that IVlG can he an effective modulator of inappropriate complement attack.
Mechanisms of action of intravenous immune globulin in immune-mediated diseases
Authors: Mouthon L , Kaveri S V , Spalter S H , Lacroix-Desmazes S , Lefranc C , Desai R , Kazatchkine M D 
Published: January 2019

Summary
Intravenous immune globulin (IVIG) exhibits a number of immunomodulatory properties that are mediated by the Fe portion of IgG and by the spectrum of variable (V) regions contained in the immune globulin preparations. Five predominant and non-exclusive mechanisms of action have been proposed to account for the immunomodulatory effects of IVIG in immune-mediated diseases: (i) functional blockade of Fe receptors on splenic macrophages: (ii) inhibition of complement-mediated damage, an effect that is dependent on the ability of IgG to bind C3b and C4b and thus reduce the number of activated complement fragments that may deposit on target surfaces of complement activation: (iii) modulation of the production of cytokines and cytokine antagonists: (iv) neutralization of circulating autoantibodies by complementary (e.g. anti-idiotypic) antibodies in IVIG, a mechanism that accounts for the rapid decrease in titre of circulating autoantibodies that is often observed within hours following the infusion of IVIG: (v) selection of immune repertoires, a complex set of effects that may be observed in individuals receiving IVIG far beyond the half-life of the infused immunoglobulin and that is directly relevant to the ability of IVIG to, for example, suppress autoantibody-producing clones in patients with antibody-mediated autoimmune disease and modulate graft versus host disease (GVHD). IVIG has been shown to downrcgulate or activate B-cell clones expressing surface IgG that is complementary (anti-idiotypic) to V regions of antibodies present in IVIG. IVIG has been shown also to interact with surface molecules of T cells that are essential to immune regulation, such as the αβ TCR, CD5, CD4, non-polymorphic determinants of MHC class I molecules and adhesion molecules of T and B cells. The complex interactions of IVIG with functional molecules of cells of the immune system are relevant to its therapeutic effects in T cell- as well as B cell- mediated diseases and indeed, to our understanding of the physiological role of normal IgG and antibody networks in controlling autoreactivity in healthy individuals.
Infectious risk of plasma donations: relationship to safety of intravenous immune globulins
Authors: Dodd R Y 
Published: January 2019

Summary
Although intravenous immune globulin (IVIG) preparations may be derived from tens of thousands of donations, the residual risk of viral contamination of recovered plasma appears remarkably low, at least for human immunodeficiency virus (HIV) and hepatitis B virus (HBV). Consequently, most pools are unlikely to contain these viruses although the situation is not as well understoof for US-derived source plasma. In addition, routine preparation methods are likely to eliminate infectivity from the relatively fragile HIV. Current plasma screening measures arc generally designed to maintain reasonable titres of anti-HBs in pools, perhaps contributing to the absence of HBV infection. The situation with respect to hepatitis C virus (HCV) is not well understood and it appears that sensitive screening for anti-HCV may have had an impact on the safety of at least one IVIG preparation. The implementation of effective viral inactivation procedures is expected to eliminate any further risk of HCV infection from IVIG preparations.
Clinical benefits and immunopathological correlates of intravenous immune globulin in the treatment of inflammatory myopathies
Authors: Dalakas M C 
Published: January 2019

Summary
High-dose intravenous immune globulin (IVIG) is emerging as a promising therapy for patients with inflammatory myopathies who have become unresponsive to, or cannot tolerate, conventional therapies. In a double-blind, placebo-controlled study, using objective criteria for improvement, IVIG demonstrated moderate to dramatic improvement in 75% of the patients with dermatomyositis. Preliminary results from a controlled study in inclusion-body myositis show that IVIG may also exert a mild benefit, but only in a small number of patients and in certain muscle groups. In some patients with polymyositis, IVIG is reported to be of benefit but controlled studies have not yet been completed. Immunocytochemical, immunological and in vitro studies on the patients' repeated muscle biopsies and follow-up sera showed that IVIG exert its action in inflammatory myopathies by: (i) inhibiting myotoxic cytokines, such as TNF-α and IL-1; (ii) blockade of Fe receptors on endomysial macrophages interfering with Fe receptor-mediated phagocytosis; and (iii) inhibiting the uptake of C3 and intercepting the formation and deposition of membranolytic attack complex on the endomysial capillaries.
Intravenous immune globulin in the treatment of intractable childhood epilepsy
Authors: Duse M , Notarangelo L D , Tiberti S , Menegati E , Plebani A , Ugazio A G 
Published: January 2019

SummaryMany clinical and experimental data strongly support the role of immune mechanisms in the pathogenesis of childhood epilepsy. Following Pechadre’s first observations with intramuscular immune globulin (IMIG), intravenous immune globulin (IVIG) has been employed in some forms of intractable childhood epilepsy (ICE), mainly ill West syndrome (WS) and Lennox Gastaut syndrome (LGS), with good results. So far, 373 children suffering from ICE have been treated in 29 studies and 174 have responded favourably. Although these studies are heterogeneous and controls are lacking, most authors report similar responsiveness ranging from 30% to 50%. Several mechanisms have been suggested to account for the efficacy of IVIG in ICE including antiviral effect, substitutive therapy in patients with concomitant humoral immunodeficiency, idiotype-anti-idiotype interaction or a neuromodulant effect. To better define the real efficacy of IVIG in ICE in paediatric patients, a randomized, multicenter, double-blind clinical trial was started in 1993. including only patients suffering from WS and LGS. To date, only one doubleblind trial had been carried out (with both adult and paediatric patients); it showed a clear trend in favour of IVIG treatment but lacked statistical significance, perhaps because of the small and heterogenous sample. Controlled multicentre studies on well-defined populations arc needed and patients with WS and LGS are probably the best candidates.
New treatment strategies for systemic vasculitis: the role of intravenous immune globulin therapy
Authors: Lock Wood C M 
Published: January 2019

SummaryIntravenous immune globulin (IVIG) is now under evaluation for the treatment of patients with the forms of systemic vasculitis associated with anti-neutrophil cytoplasmic antibodies (ANCA). Although IVIG may produce effects by a variety of mechanisms, including control of T-cell function, interference with cytokine action, and Fe receptor blockade, it is the regulation of autoantibody production by B cells, through idiotypic-anti-idiotypic reactions, that makes this treatment attractive for patients with systemic vasculitis. The author and others have shown the importance of ANCA idiotypic-anti-idiotypic reactions in vitro and demonstrated that these could be influenced by anti-idiotypic determinants present in IVIG. Thus F(ab′)2 fragments of IVIG could block ANCA binding to antigen, in a dose-dependent fashion. The degree of inhibition was variable, ranging up to 100% for the ANCA-containing sera of certain patients. Similar inhibitory activity could be found in the sera of patients in remission after treatment, as well as in occasional patients whose disease remitted spontaneously, without drugs being used. Thus, IVIG appears to be particularly valuable in the management of vasculitis in the elderly, the very young and for pregnant women, as well as for those at any age who are vulnerable to infection.