bluuebunny/crossref_metadata_2025_split huggingface dataset:
Estimation of the average time to failure of the turning steps according to the operation data
Authors: Belousova M. V. , Bulatov V. V. 
Published: May 2019

The purpose of this study is to determine the empirical law of the distribution of developments to the failure of the turning steps installed on passenger cars of locomotive traction. The correct choice of the distribution law for each technical product allows for the current calculation of reliability indicators, predicting them, as well as developing preventive measures for a specific technical product and leveling costs both during production and during operation.The article presents well-founded arguments that the failure time for turning steps is characterized by the Weibull distribution law. For confirmation, a statistical criterion for checking the deviation of the distribution from the normal one was applied.On the basis of carried statistic analysis a histogram of frequencies and a line of the density function of samples of failure time in the data fixation period from 2010 to 2017 were built. Results of applying the 2 agreement criterion in the same software environment revealed that the failure time of the closed turning step comply with the law of Weibull distribution. Authors suggest using the maximum likelihood method to identify Weibull distribution parameters, on the basis of which the value of the point estimate of the mean time to failure is calculated.Based on the research, it is concluded that this type of distribution law and the process of finding its parameters should be introduced into the program and methodology for assessing the operational reliability of the turning steps, when calculating the average time to failure of the steps, and consider the possibility of applying this law for analogous products.In conclusion, calculation of the pointed estimation of the average time to failure of the closed turning step was made on the basis of operational tests for one year in accordance with the adopted distribution law.
Development of the lubricant for side-mounted rail flange lubricators for traction rolling stock
Authors: Glazunov D. V. 
Published: May 2019

Specificity of operating conditions of the rolling stock defines a number of requirements for lubricants intended for the wheel-rail tribosystem. Lubricants are used for “wheel — rail” contact, the aggregate state of which varies from liquid to solid. When evaluating the lubrication properties of these materials, a significant number of factors must be taken into account, in particular, influence of the environment, method of application, condition of the rail surface. The paper discusses the main operational requirements for lubricants operating in a wheel-rail tribosystem. Temperature ranges of the lubricants used for the “wheel — rail” contact on the railway network of the Russian Federation are given. As a result of the research, it was determined that none of the materials used for lubrication of the wheel-rail system satisfies the operating temperature conditions of the traction rolling stock. To solve this problem a lubricant was developed and tested in an industrial environment at the Rostov State University of Railway Transport. Its lubricant composition allows to significantly expand the temperature range of the lubricant. Complex of experimental studies and method of orthogonal central composite plan of the 2nd order established the optimum values of the thickness of the working shell of the 0.846 mm lubricating rod and the 50.411 % percentage of plastic lubricant, allowing to extend the temperature range of lubricant rods and, in particular, completely eliminate the lubricant flow to achieve a temperature of 126.034 °C. Proposed composition of the lubricant was tested on a freight electric locomotive of the VL80T series, equipped with non-power lubricators, under the conditions of the Bataysk — Likhaya section of the North Caucasus Railway. Intensity of wear of the wheel flanges of the traction rolling stock lubricated by the proposed material, compared with the intensity of wear of the wheel flanges without the use of lubrication systems is reduced by 2 times.
Treatment patterns and costs among biologic-naive patients initiating apremilast or biologics for psoriatic arthritis
Authors: Feldman Steven R , Pelletier Corey L , Wilson Kathleen L , Mehta Rina K , Brouillette Matthew A , Smith David , Bonafede Machaon M 
Published: May 2019

Aim:
We evaluated treatment patterns and healthcare costs of initiating psoriatic arthritis (PsA) treatment with oral apremilast versus biologics.
Methods:
Claims data identified biologic-naive adults with PsA who initiated either apremilast or a biologic from 2013 to 2016.
Results:
Medication adherence was similar at 12 months (76.9 vs 73.4%; p = 0.175) between apremilast (n = 381) and matched biologic (n = 761) patients. Apremilast users had $12,715 lower total costs per-patient-per-month (p < 0.001), largely due to outpatient pharmacy and medical costs.
Conclusion:
Commercially insured patients with PsA initiating apremilast had adherence similar to those initiating biologics but lower total healthcare costs.
EFEKTIVITAS PELAKSANAAN TERAPI DIET CASEIN FREE GLUTEN FREE PADA ANAK AUTIS DI KOTA PEKANBARU
Authors: Rahmana Fatma Richa 
Published: May 2019

<p>Pelaksanaan Terapi Diet casein free gluten free pada anak autis merupakan salah satu bentuk terapi pada autis untuk mengurangi gejala autistik pada anak autis sendiri.dimana pelaksanaan terapi diet ini harus dilakukan dengan ketat. Orang tua anak autis harus memahami terlebih dahulu mengenai makanan dan minuman apa saja yang mengandung casein dan gluten.dengan demikian pelaksanaan terapi diet casein free gluten free pada anak autis dapat dilaksanakan dengan maksimal. Penelitian ini bertujuan untuk<strong> </strong>mengetahui Efektivitas pelaksanaan terapi diet Casein free glutein free terhadap prilaku autistik anak autis di Kota pekanbaru<strong> </strong>dengan memberikan kuisioner dan wawancara terhadap orang tua anak autis.Penelitian ini merupakan penelitian kuantitatif analitik observasional dengan jenis desain <em>Quasi eksperiment</em>, dengan rancangan <em>Pre and Post Test With Control Design.</em> Dengan membandingkan dua hasil evaluasi yaitu <em>pre test</em> dan <em>post test</em>. Populasi dalam penelitian ini adalah anak autis sebanyak 50 orang yang dibagi menjadi 2 kelompok. Kelompok 1 sebagai kelompok eksperimen yang diberikan kuesioner yang dilengkapi dengan <em>Informed Concent</em> terhadap orang tua anak autis. sekaligus diberikan terapi diet casein free glutein free pada anak autis selama 6 minggu .sedangkan kelompok 2 sebagai kelompok kontrol yang diberikan kuesioner meliputi data karakteristik naka autis yang diberikan kepada orang tua nya dengan menjawab 15 pertanyaan. Penelitian ini mengggunakan uji hipotesis <em>Paired Sample T-test</em> utuk mengetahui efektivitas pelaksanaan terapi diet casein free glutein free pada anak autis. Kemudian untuk uji beda pengaruh antara kelompok ekspersimen dan kelompok kontrol digunakan uji <em>Independent Sample T-test</em>.</p>
UTILIZING MICROSOFT MATHEMATICS IN TEACHING AND LEARNING CALCULUS
Authors: Oktaviyanthi Rina , Supriani Yani 
Published: May 2019

The experimental design was conducted to investigate the use of Microsoft Mathematics, free software made by Microsoft Corporation, in teaching and learning Calculus. This paper reports results from experimental study details on implementation of Microsoft Mathematics in Calculus, studentsâ€™ achievement and the effects of the use of Microsoft Mathematics on studentsâ€™ attitudes in relation to such experience. Two classes of the students from the first year student in Universitas Serang Raya were participated in the study. This study found that students who taught by using Microsoft Mathematics had higher achievement and has a positive effect on studentsâ€™ confidence of mathematics.Keywords: Calculus, Educational Technology, Mathematics Education, Microsoft Mathematics, Technology ApplicationÂ DOI: dx.doi.org/10.22342/jme.61.63
INVESTIGATING THE ACT OF DESIGN IN DISCHARGE CONCEPT USING PMRI
Authors: Lestariningsih Lestariningsih , Anwar Muhammad , Setiawan Agus Mulyanto 
Published: May 2019

The goal of this research is to investigate the act of design in discharge concept using Pendidikan Matematika Realistik Indonesia (PMRI) approach with Lapindo's Mud phenomenon as a context. Design research was chosen as method used in this research that consist of three phases, namely preparing for the experiment, teaching experiment,Â and retrospective analysis. Based on the result of investigating from findings and the data obtained in this research, it can be concluded that the use of instructional design using PMRI can support students' understanding in learning the concept of discharge. Observing activities Lapindo mud photos, watching videos Lapindo mud, observing miniature discharge of Lapindo mud, volume of water and time of data collection are needed, and finding discharge of Lapindo mud are conducted in this research.Keywords: discharge, design research, PMRIÂ DOI: dx.doi.org/10.22342/jme.72.129
USING SET MODEL FOR LEARNING ADDITION OF INTEGERS
Authors: Lestari Umi Puji , Putri Ratu Ilma Indra , Hartono Yusuf 
Published: May 2019

This study aims to investigate how set model can help students' understanding of addition of integers in fourth grade. The study has been carried out to 23 students and a teacher of IVC SD Iba Palembang in January 2015. This study is a design research that also promotes PMRI as the underlying design context and activity. Results showed that the use of set models that is packaged in activity of recording of financial transactions in two color chips and card game can help students to understand the concept of zero pair, addition with the same colored chips, and cancellation strategy.Keywords: addition of integers, set models, PMRI, design researchÂ DOI: dx.doi.org/10.22342/jme.62.93
Eksistensi dan Konstruksi Yuridis Badan Usaha Milik Daerah Pasca Undang-Undang Pemerintahan Daerah Tahun 2014
Authors: Syam Fauzi , Rahmi Elita , Arsyad Arsyad 
Published: May 2019

This article discusses juridical implications about the regulation of state-owned enterprises (BUMD) after the enactment of the Law Number 23 Year 2014 about Regional Government (Regional Government Law 2014) and the application on regulation of BUMD in Jambi Province. Research methode in this study is normative juridical with law approach. Based on the results of the study are known, the enactment of Regional Government Law 2014 has implications for the existence and regulations of existing and future of BUMD, namely in terms of form and naming of BUMD; organ of BUMD; tenure of directors and councils; and intervention of DRPD (Regional People’s Representative Assembly) on BUMD operations. The result of the study also shows that not one regional government in Jambi Province that followed up on the mandate of the article 402 paragraph (1) Regional Government Law 2014 to adjust the regulation of BUMD, and that’s why it is potentially contradicting with Regional Government Law 2014 and central government policy.
Abstrak
Artikel ini membahas implikasi yuridis pengaturan Badan Usaha Milik Daerah (BUMD) pasca berlakunya Undang-Undang Nomor 23 Tahun 2014 tentang Pemerintahan Daerah (UU Pemda 2014) dan penerapannya pada regulasi BUMD di lingkungan Provinsi Jambi. Metode penelitian yang digunakan adalah yuridis normatif dengan pendekatan perundang-undangan. Berdasarkan hasil kajian diketahui, berlakunya UU Pemda 2014 berimplikasi terhadap eksistensi dan regulasi BUMD baik yang telah ada maupun yang akan dibentuk, yaitu dalam hal bentuk hukum dan penamaan BUMD; persyaratan pendirian dan kelayakan usaha BUMD; penyertaan modal daerah dan kepemilikan modal dalam BUMD; organ BUMD; masa jabatan Direksi dan Dewas/Deris; dan campur tangan DPRD dalam operasional BUMD. Hasil penelitian juga menunjukkan belum ada satu pun Pemda di lingkungan Provinsi Jambi yang menindaklanjuti amanat Pasal 402 ayat (1) UU Pemda 2014 untuk menyesuaikan regulasi BUMD, dan dengan demikian potensial bertentangan dengan UU Pemda 2014 dan kebijakan pemerintah pusat.
Global longitudinal strain in prosthesis-patient mismatch: relation to left ventricular mass regression and outcomes
Authors: Zhang Hong-wei , Gu Jun , Xiao Zheng-hua , Li Ya-jiao , Yang Peng , Huang Yao , Lu Chen , Zhang Er-yong , Hu Jia 
Published: May 2019

Aims
Aortic prosthesis-patient mismatch (PPM) increases left ventricular (LV) afterload and prevents LV mass regression (LVMR) after surgery. This study was designed to investigate the association between the baseline global longitudinal strain (GLS) and the postoperative LVMR, and its relation to adverse outcomes.

Methods
A total of 316 patients with aortic stenosis undergoing isolated mechanical prosthesis implantation were screened, and data from 91 patients with aortic PPM and 165 non-PPM patients were retrospectively collected. All 256 patients underwent measurement of GLS by two-dimensional speckle-tracking echocardiography preoperatively, and were followed up for postoperative changes of LV mass index (LVMi) and other clinical outcomes.

Results
During the follow-up, LVMi in PPM patients decreased significantly from 139.6 ± 20.8 to 119.6 ± 26.5 g/m2 (P < 0.001). These patients were divided into two groups according to the median value of the reduction rate of LVMi at final follow-up, and preoperative GLS markedly decreased in PPM patients with insignificant reduction in LVMi. Multivariate analysis identified preoperative GLS (odds ratio 3.45, 95% confidence interval 1.27–11.05, P = 0.002) and preoperative LVMi (odds ratio 2.87, 95% confidence interval 1.21–8.13, P = 0.012) as independently associated with an insignificant LVMR. Moreover, PPM patients with limited reduction in LVMi were at an increased risk of cardiac death and major adverse valve-related events.

Conclusion
In patients with aortic PPM early after surgery, reduced preoperative GLS could be a novel sensitive risk factor for a limited regression of LV hypertrophy, and this is associated with an increased risk of adverse events in PPM patients.
Leukocytosis interference in clinical chemistry: shall we still interpret test results without hematological data?
Authors: Grzych Guillaume , Roland Estelle , Beauvais David , Maboudou Patrice , Lippi Giuseppe 
Published: May 2019

SummaryBackgroundExtreme leukocytosis is known to induce remarkable variations of some clinical chemistry tests, thus leading to possible clinical misinterpretation. This study aimed to define whether also moderate leukocytosis may influence the stability of glucose and blood gases.MethodsBlood samples are sent to the local laboratory through a pneumatic tube system. Clinical chemistry testing is routinely performed using lithium-heparin tubes (for glucose) and heparin blood gases syringes (for blood gas analysis). Stability of glucose (in uncentrifuged blood tubes) and blood gases (in syringes) was hence evaluated in samples maintained at room temperature. Results were also analyzed in 2 subgroups of samples with different leukocyte counts, i.e., those with leukocytes <15 × 109/L and those with leukocytes >15 × 109/L.ResultsAn accelerated decrease of pH was observed in blood gases syringes with leukocytosis (i.e., >15 × 109/L), while no difference was noted for other blood gases parameters (PCO2, PO2). Spurious and time-dependent hypoglycemia was noted in uncentrifuged blood tubes of patients with leukocytosis.ConclusionsThe results of our study suggest that even modest leukocytosis (i.e., around 15 × 109/L), which is frequently encountered in clinical and laboratory practice, may be associated with significant variations of both glucose and pH. This would lead us to conclude that results of these parameters shall be accompanied by those of hematologic testing to prevent clinical misinterpretation, namely with leukocyte counts.
Application of targeted next generation sequencing for the mutational profiling of patients with acute lymphoblastic leukemia
Authors: Janic Dragana , Peric Jelena , Karan-Djurasevic Teodora , Kostic Tatjana , Marjanovic Irena , Stanic Bojana , Pejanovic Nadja , Dokmanovic Lidija , Lazic Jelena , Krstovski Nada , Virijevic Marijana , Tomin Dragica , Vidovic Ana , Suvajdzic Vukovic Nada , Pavlovic Sonja , Tosic Natasa 
Published: May 2019

SummaryBackgroundAcute lymphoblastic leukemia (ALL) is the most common cancer in children, whereas it is less common in adults. Identification of cytogenetic aberrations and a small number of molecular abnormalities are still the most important risk and therapy stratification methods in clinical practice today. Next generation sequencing (NGS) technology provides a large amount of data contributing to elucidation of mutational landscape of childhood (cALL) and adult ALL (aALL).MethodsWe analyzed DNA samples from 34 cALL and aALL patients, using NGS targeted sequencing TruSeq Amplicon – Cancer Panel (TSACP) which targets mutational hotspots in 48 cancer related genes.ResultsWe identified a total of 330 variants in the coding regions, out of which only 95 were potentially protein-changing. Observed in individual patients, detected mutations predominantly disrupted Ras/RTK pathway (STK11,KIT,MET,NRAS,KRAS,PTEN). Additionally, we identified 5 patients with the same mutation inHNF1Agene, disrupting both Wnt and Notch signaling pathway. In two patients we detected variants inNOTCH1gene.HNF1AandNOTCH1variants were mutually exclusive, while genes involved in Ras/RTK pathway exhibit a tendency of mutation accumulation.ConclusionsOur results showed that ALL contains low number of mutations, without significant differences between cALL and aALL (median per patient 2 and 3, respectively). Detected mutations affect few key signaling pathways, primarily Ras/RTK cascade. This study contributes to knowledge of ALL mutational landscape, leading to better understanding of molecular basis of this disease.
Determination of User’s Position Using QZSS/GPS Data
Authors: Làn Đào Thị , Dung Le Tien 
Published: May 2019

Abstract: This paper presents study results of standalone positioning, based on GPS/QZSS observations. For this purpose C1 code observations from STK2 station (IGS station in Japan) were used. Computations in RTKLIB software (RTKPOST module) were executed and SPP method was used to position estimation. In the paper two experiments were realized: firstly user’s position was estimated based on GPS observations, and in the second case QZSS observations were applied also. Preliminary results of positioning accuracy show that GPS/QZSS solution improve accuracy of X coordinate about 0.398 m, accuracy of Y coordinate about 0.432 m and accuracy of Z coordinate about 0.285 m, respectively. Additionally RMS-3D error was estimated based on coordinate differences from GPS and GPS/QZSS solutions. Average value of RMS-3D term equals to 0.986 m, with magnitude order between 0.003 m and 3.649 m.
Keywords: GPS, SPP Method. QZSS-Zenith
Synthesis and Characterization of Ni2+-doped TiO2 Nanowires
Authors: Loan Trinh Thi , Huong Vu Hoang , Dung Tran Thi , Long Nguyen Ngoc 
Published: May 2019

Abstract: TiO2 nanowires doped with different amounts of Ni2+ ions (from 0 to 18 mol%) were synthesized by hydrothermal technique. The samples were characterized by X-ray diffraction (XRD) and Raman spectroscopy, field emission scanning electron microscopy (FESEM), and diffuse reflection spectroscopy. The XRD analysis showed that the doped samples exhibit anatase single phase. The lattice parameters remain unchanged, independent on Ni2+ content. Diameter of TiO2 nanowires increased significantly with increasing concentrations of Ni2+. The investigated results indicate that a greater portion of the Ni2+ ions are well-incorporated into the anatase TiO2 lattice. Indirect and direct band gap energies of Ni2+-doped TiO2 with different doping concentration were found to be in the range from 3.24 to 2.99 eV and 3.54 to 3.35 eV, respectively.
Keywords: TiO2:Ni2+ nanowires, hydrothermal, diffuse reflection, band gap energy.
Kriteria Penetapan Lokasi Stasiun Kereta Api Penumpang
Authors: Kuswati Atik S 
Published: May 2019

This study intends to determinate criteria of the station location which the aim is to providing input in the policy that criteria. The priority of creteria and sub criteria the station location is determinated by using Analytical Hierarchy Process (AHP). Based on processing and analysis of data are obtained the aspect of regulation is more priority than other criteria in determining the railway passenger station location. The other aspects are of the economic environment, accessibility and connectivity, as well as operational. For sub-criteria, the suitability of the national railway master plan (Ripnas) is more priority than land-use aspects (spatial plan). For Sub-economic criteria, the first aspect is the economic potential in the region/ growth area. For sub accessibility and connectivity criteria consider about distance within the downtown stationKey words: criteria, passenger station Kajian ini bermaksud menyusun kriteria penetapan lokasi stasiun kereta api pen um pang dengan tujuan memberikan masukan dalam kebijakan kriteria penetapan lokasi stasiun kereta api penumpang. Dengan menggunakan Analytical Hierarchy Process (AHP) maka akan ditentukan prioritas dari kriteria dan sub kriteria untuk penentuan lokasi stasiun. Dari pengolahan dan analisis data diperoleh hasil bahwa aspek regulasi merupakan prioritas utama dalam penentuan lokasi stasiun penumpang kereta api, diikuti oleh aspek lingkungan ekonomi, aksesibilitas dan konektivitas, serta operasional. Untuk sub kriteria, kesesuaian rencana induk perkeretaapian nasional (Ripnas) sebagai prioritas dibandingkan aspek tata guna lahan (rencana tata ruang wilayah). Sub kriteria ekonomi yang menjadi urutan pertama adalah potensi ekonomi di wilayah/kawasan pertumbuhan. Untuk sub kriteria aksesibilitas dan konektivitas adalah pertimbangan jarak stasiun dengan pusat kota.Kata kunci: kriteria, stasiun penumpang