bluuebunny/crossref_metadata_2025_split huggingface dataset:
The contribution of mitochondrial metagenomics to large-scale data mining and phylogenetic analysis of Coleoptera
Authors: Linard Benjamin , Crampton-Platt Alex , Moriniere Jérome , Timmermans Martijn J.T.N. , Andujar Carmelo , Arribas Paula , Miller Kirsten E. , Lipecki Julia , Favreau Emeline , Hunter Amie , Gómez-Rodríguez Carola , Barton Christopher , Nie Ruie , Gillett Conrad P.D.T. , Breeschoten Thijmen , Bocak Ladislav , Vogler Alfried P. 
Published: March 2018

AbstractA phylogenetic tree at the species level is still far off for highly diverse insect orders, including the Coleoptera, but the taxonomic breadth of public sequence databases is growing. In addition, new types of data may contribute to increasing taxon coverage, such as metagenomic shotgun sequencing for assembly of mitogenomes from bulk specimen samples. The current study explores the application of these techniques for large-scale efforts to build the tree of Coleoptera. We used shotgun data from 17 different ecological and taxonomic datasets (5 unpublished) to assemble a total of 1942 mitogenome contigs of >3000 bp. These sequences were combined into a single dataset together with all mitochondrial data available at GenBank, in addition to nuclear markers widely used in molecular phylogenetics. The resulting matrix of nearly 16000 species with two or more loci produced trees (RAxML) showing overall congruence with the Linnaean taxonomy at hierarchical levels from suborders to genera. We tested the role of full-length mitogenomes in stabilizing the tree from GenBank data, as mitogenomes might link terminals with non-overlapping gene representation. However, the mitogenome data were only partly useful in this respect, presumably because of the purely automated approach to assembly and gene delimitation, but improvements in future may be possible by using multiple assemblers and manual curation. In conclusion, the combination of data mining and metagenomic sequencing of bulk samples provided the largest phylogenetic tree of Coleoptera to date, which represents a summary of existing phylogenetic knowledge and a defensible tree of great utility, in particular for studies at the intra-familial level, despite some shortcomings for resolving basal nodes.
The tumor suppressor BRCA1/BARD1 complex localizes to the synaptonemal complex and regulates recombination under meiotic dysfunction inCaenorhabditis elegans
Authors: Li Qianyan , Saito Takamune T. , Deshong Alison J. , Garcia Marina Martinez , Nadarajan Saravanapriah , Lawrence Katherine S. , Checchi Paula M. , Colaiacovo Monica P. , Engebrecht JoAnne 
Published: March 2018

AbstractBreast cancer susceptibility gene 1(BRCA1) and binding partner BRCA1-associated RING domain protein 1 (BARD1) form an essential E3 ubiquitin ligase important for DNA damage repair and homologous recombination. InCaenorhabditis elegansBRCA1/BRC-1 and BARD1/BRD-1 orthologs are not essential, but function in DNA damage repair and homologous recombination, as well as in meiosis. In proliferating germ cells and in early meiotic prophase, BRC-1 and BRD-1 are nucleoplasmic, with enrichment at foci that partially overlap with the recombinase RAD-51. In mid-pachytene, BRC-1 and BRD-1 are observed on tracks, before concentrating to the short arms of bivalents, co-localizing with a central region component of the synaptonemal complex. We found that BRD-1 is essential for BRC-1 to associate with chromatin and the synaptonemal complex, but BRC-1 is not required for BRD-1 localization; the complex fails to properly localize in the absence of either meiotic recombination or chromosome synapsis. Inactivation of BRC-1/BRD-1 enhances the embryonic lethality of mutants that perturb chromosome synapsis and crossover recombination, suggesting that BRC-1/BRD-1 plays an important role in monitoring recombination in the context of the synaptonemal complex. We discovered that BRC-1/BRD-1 stabilizes the RAD51 filament when the formation of a crossover-intermediate is disrupted. Further, in the absence of BRC-1/BRD-1 crossover distribution is altered, and under meiotic dysfunction, crossover numbers are perturbed. Together, our studies indicate that BRC-1/BRD-1 localizes to the synaptonemal complex where it serves a checkpoint function to monitor and modulate meiotic recombination.Project SummaryOur genomes are passed down from one generation to the next through the specialized cell division program of meiosis. Meiosis is highly regulated to coordinate both the large scale chromosomal and fine scale DNA events to ensure fidelity. We analyzed the role of the tumor suppressor BRCA1/BARD1 complex in meiosis in the worm,Caenorhabditis elegans. We find that BRCA1/BARD1 localizes dynamically to the proteinaeous structure that aligns maternal and paternal chromosomes, where it regulates crossover recombination. Although BRCA1/BARD1 mutants have only subtle meiotic defects, we show that this complex plays a critical role in meiotic recombination when meiosis is perturbed. These results highlight the complexity of ensuring accurate transmission of the genome and uncover the requirement for this conserved complex in meiosis. As women carrying BRCA1 mutations with no indication of cancer have fertility defects, our results provide insight into why BRCA1 mutations impact reproductive success.
Detection and classification of hard and soft sweeps from unphased genotypes by multilocus genotype identity
Authors: Harris Alexandre M. , Garud Nandita R. , DeGiorgio Michael 
Published: March 2018

AbstractPositive natural selection can lead to a decrease in genomic diversity at the selected site and at linked sites, producing a characteristic signature of elevated expected haplotype homozygosity. These selective sweeps can be hard or soft. In the case of a hard selective sweep, a single adaptive haplotype rises to high population frequency, whereas multiple adaptive haplotypes sweep through the population simultaneously in a soft sweep, producing distinct patterns of genetic variation in the vicinity of the selected site. Measures of expected haplotype homozygosity have previously been used to detect sweeps in multiple study systems. However, these methods are formulated for phased haplotype data, typically unavailable for nonmodel organisms, and may have reduced power to detect soft sweeps due to their increased genetic diversity relative to hard sweeps. To address these limitations, we applied the H12 and H2/H1 statistics of Garud et al. [2015] to unphased multilocus genotypes, denoting them as G12 and G2/G1. G12 (and the more direct expected homozygosity analogue to H12, denoted G123) has comparable power to H12 for detecting both hard and soft sweeps. G2/G1 can be used to classify hard and soft sweeps analogously to H2/H1, conditional on a genomic region having high G12 or G123 values. The reason for this power is that under random mating, the most frequent haplotypes will yield the most frequent multilocus genotypes. Simulations based on parameters compatible with our recent understanding of human demographic history suggest that expected homozygosity methods are best suited for detecting recent sweeps, and increase in power under recent population expansions. Finally, we find candidates for selective sweeps within the 1000 Genomes CEU, YRI, GIH, and CHB populations, which corroborate and complement existing studies.
Hit count estimate variability for website-specific queries in search engines
Authors: Font-Julian Cristina I. , Ontalba-Ruipérez José-Antonio , Orduña-Malea Enrique 
Published: March 2018

Purpose
The purpose of this paper is to determine the effect of the chosen search engine results page (SERP) on the website-specific hit count estimation indicator.

Design/methodology/approach
A sample of 100 Spanish rare disease association websites is analysed, obtaining the website-specific hit count estimation for the first and last SERPs in two search engines (Google and Bing) at two different periods in time (2016 and 2017).

Findings
It has been empirically demonstrated that there are differences between the number of hits returned on the first and last SERP in both Google and Bing. These differences are significant when they exceed a threshold value on the first SERP.

Research limitations/implications
Future studies considering other samples, more SERPs and generating different queries other than website page count (<site>) would be desirable to draw more general conclusions on the nature of quantitative data provided by general search engines.

Practical implications
Selecting a wrong SERP to calculate some metrics (in this case, website-specific hit count estimation) might provide misleading results, comparisons and performance rankings. The empirical data suggest that the first SERP captures the differences between websites better because it has a greater discriminating power and is more appropriate for webometric longitudinal studies.

Social implications
The findings allow improving future quantitative webometric analyses based on website-specific hit count estimation metrics in general search engines.

Originality/value
The website-specific hit count estimation variability between SERPs has been empirically analysed, considering two different search engines (Google and Bing), a set of 100 websites focussed on a similar market (Spanish rare diseases associations), and two annual samples, making this study the most exhaustive on this issue to date.
Analysis of the behaviour of the clients assisted and sales variables in the different phases of the product life cycle
Authors: Galiano Aida , Rodríguez Vicente , Saco Manuela 
Published: March 2018

Purpose
The Bass model was created to analyse the product life cycle (PLC) in order to help sales and marketing departments in their business decision making. The purpose of this paper is to analyse the diferences between the clients assisted and sales variables, to discover which of the two variables is the more useful for the estimation of the PLC phases through the Bass model, thus aiding the managers of company sales and marketing departments.

Design/methodology/approach
In this research, the authors analysed the 223,577 clients assisted by a nationwide network of car dealerships, who acquired 36,819 vehicles, during a 24-month period. In the analysis, the Bass model was applied to define the PLC phases; and nonlinear regression models were used to carry out the estimations.

Findings
The results show that more consistent estimates of the PLC phases are obtained from the clients assisted variable. This work has theoretical and practical implications that can help business management.

Research limitations/implications
The most remarkable thing about this research is that we have shown that the functionality of the clients assisted variable is greater than the sales variable for the Bass model and, therefore, for PLC estimation.

Practical implications
The results of this research are very useful, since they allow marketing decision makers to obtain more consistent estimations of the PLC phases using the Bass model and the clients assisted variable. This is based on the fact that the use of this variable helps to detect if there is any deficiency in the design of the marketing strategy when the client does not make the purchase.

Social implications
The data on clients assisted are as easily available to companies as sales data. However, the use of this variable improves PLC analysis and this allows an improvement in company forecasting. Thus, making the clients assisted variable a tool to strategically plan investments in innovation and marketing would reduce uncertainty in business management.

Originality/value
The purpose of this paper is to analyse the diferences between the clients assisted and sales variables, to discover which of the two variables is the more useful for the estimation of the PLC phases through the Bass model, thus aiding the managers of company sales and marketing departments.
Trends and directions in service triads research
Authors: Sengupta Sourav , Niranjan Tarikere T. , Krishnamoorthy Mohan 
Published: March 2018

PurposeService triads refer to tripartite relationships in which client firms serve their customers through third-party service providers. The purpose of this paper is to systematically review the nascent but fast-growing literature on service triads to explore the broad themes along which the literature has grown, and to identify the gaps and future research opportunities.Design/methodology/approachSystematic literature review (SLR) approach is adopted to retrieve, select, and synthesise relevant service triads studies. A citation network analysis on the corpus resulting from the SLR identified the core articles of the literature.FindingsThe SLR uncovered ten themes of research along the articles’ objectives, theories and methodologies. The classification framework of service triads, the roles of customers and providers, the size of the provider, triadic risks, controlling service delivery and service quality, regulated triads, the stability of the triads, and cross-country, cross-culture triads emerged as significant under-researched areas.Originality/valueThe paper illustrates research trends and provides insights into the neglected and under-researched problems of service triads. This is the first SLR on service triads.
Team performance in the Italian NHS: the role of reflexivity
Authors: Urbini Flavio , Callea Antonino , Chirumbolo Antonio , Talamo Alessandra , Ingusci Emanuela , Ciavolino Enrico 
Published: March 2018

Purpose
The purpose of this paper is twofold: first, to investigate the goodness of the input-process-output (IPO) model in order to evaluate work team performance within the Italian National Health Care System (NHS); and second, to test the mediating role of reflexivity as an overarching process factor between input and output.

Design/methodology/approach
The Italian version of the Aston Team Performance Inventory was administered to 351 employees working in teams in the Italian NHS. Mediation analyses with latent variables were performed via structural equation modeling (SEM); the significance of total, direct, and indirect effect was tested via bootstrapping.

Findings
Underpinned by the IPO framework, the results of SEM supported mediational hypotheses. First, the application of the IPO model in the Italian NHS showed adequate fit indices, showing that the process mediates the relationship between input and output factors. Second, reflexivity mediated the relationship between input and output, influencing some aspects of team performance.

Practical implications
The results provide useful information for HRM policies improving process dimensions of the IPO model via the mediating role of reflexivity as a key role in team performance.

Originality/value
This study is one of a limited number of studies that applied the IPO model in the Italian NHS. Moreover, no study has yet examined the role of reflexivity as a mediator between input and output factors in the IPO model.
Leader-member exchange and leader identification: comparison and integration
Authors: Li Jie , Furst-Holloway Stacie , Masterson Suzanne S. , Gales Larry M. , Blume Brian D. 
Published: March 2018

PurposeThe purpose of this paper is to compare and integrate leader-member exchange (LMX) and leader identification (LID) as concurrently functioning mediators between three leadership styles (individual-focused transformational, contingent reward, and benevolent paternalistic) and two citizenship behaviors (helping and taking charge).Design/methodology/approachData included 395 stable, independent leader-follower dyads from numerous Chinese organizations. Partial least squares structural equation modeling and relative weight analysis were used in data analyses.FindingsIn established, steady-state leader-member alliances, LMX was the dominant explanation between various leadership styles and helping; whereas LID explained leadership effects on taking charge. Three-stage indirect effects of leadership-LMX-LID-taking charge were found. Also, LMX and LID related to the three focal leadership styles in distinct ways.Research limitations/implicationsLimitations include cross-sectional data. Strengths include a large, multi-source field sample. Implications include that LMX and LID provide different prosocial motivations; LMX indirectly engenders stronger other-orientation through LID; and the nature of indirect leadership effects via LID is more sensitive to the nature of the focal leadership styles. LMX and LID together provide a package of prosocial motivations.Practical implicationsLeaders interested in increasing employees’ helping vs taking charge behaviors can be more effective by understanding the different motivational potentials of LMX vs LID. Leaders also need to choose appropriate behavioral styles when they activate LMXvis-à-visLID.Originality/valueThis study integrates multiple leadership theories to provide a nuanced account of how social exchange and self-concept explain leadership at the interpersonal level when leadership styles, LMX, and LID are stable.
Upstream social marketing strategy
Authors: Kennedy Ann-Marie , Kemper Joya A. , Parsons Andrew Grant 
Published: March 2018

PurposeThis paper aims to provide guidelines for upstream social marketing strategy on to whom, how and when social marketers can undertake upstream social marketing.Design/methodology/approachThis article is a conceptual piece using academic literature to justify and conceptualise an approach to communicating with and influencing upstream actors.FindingsSpecifically, it looks at the characteristics of policymakers targeted, then targeting methods, with a special focus on the use of media advocacy. Finally, a process of government decision-making is presented to explain message timing and content.Practical implicationsSpecific criteria to judge time of decision-making and implementation guidelines are provided for social marketers.Originality/valueIn the case of complex social problems, such as obesity and environmental degradation, structural change is needed to provide people with the ability to change (Andreasen, 2006). Strategic social marketing has identified upstream social marketing as a method to influence structural change through policymakers (French and Gordon, 2015); however, literature in the area tends to be descriptive and there are no clear guidelines to its implementation (Dibb, 2014). This article seeks to provide those guidelines.
Impact of price adjustment speed on the stability of Bertrand–Nash equilibrium and profit of the retailers
Authors: T.M. Rofin , Mahanty Biswajit 
Published: March 2018

Purpose
The purpose of this paper is to investigate the impact of price adjustment speed on the stability of Bertrand–Nash equilibrium in the context of a dual-channel supply chain competition.

Design/methodology/approach
The paper considers a dual-channel supply chain comprising a manufacturer, a traditional retailer and an online retailer. A two-dimensional discrete dynamical system is used to examine the Bertrand competition between the retailers. The retailers are assumed to follow bounded rational expectations. Local stability of Bertrand–Nash equilibrium is investigated with respect to the price adjustment speed.

Findings
As the price adjustment speed increases, the stability of Bertrand–Nash equilibrium is lost, leading to complex chaotic dynamics. The results showed that chaotic dynamics deteriorates the profit of the retailers. The authors also found that the chaos can be controlled using an adaptive adjustment mechanism and the retailers enjoy higher profit when the chaos is controlled.

Practical implications
This study helps retail managers to choose an appropriate price adjustment speed to maximize profit.

Originality/value
The heterogeneity of the retailers is not considered in the studies involving dynamics of retailer competition. This paper contributes to the literature by considering the operational difference between a traditional retailer and an online retailer, i.e. price adjustment speed. In addition, the study establishes a link between price adjustment speed and profit.
Career path from a dentist to a leader
Authors: Tuononen Tiina A. , Suominen Anna Liisa , Lammintakanen Johanna 
Published: March 2018

Purpose
The purpose of this paper was to study the career paths of leaders with a career background as a dentist from basic degree to chief or executive leadership positions and individual factors that influenced their decisions.

Design/methodology/approach
Semi-structured interview and a questionnaire were used to study 13 leaders using the structure of Edgar Schein’s career anchor interview and career orientation inventory questionnaire. Theory-driven content analysis was used to analyze the data according to themes which included career paths, factors associated with job and career changes and thoughts about future careers.

Findings
Three different career path types were identified: Progressives (Type A), By chance (Type B), and Enthusiasts (Type C). The main motives were: the Progressives’ goal orientation to proceed to higher leadership positions, the By chance group’s job and even career changing by taking a chance on an interesting possibility that comes their way and the Enthusiasts’ willingness to make a difference and search for possibilities to change things. The most important career anchor was “pure challenge” among the Progressives and By chance groups and “general managerial competence” among the Enthusiasts.

Originality/value
Studies on personal factors associating with career paths in health care are scarce and similarly leaders with a dentist background are less studied, even though leadership could be an excellent career choice for a dentist. Different individuals can have varied motives and career paths toward executive positions. Because of the multi-professional functions in health care, organizations could benefit from having leaders with different expertise backgrounds.
HR practices for explorative and exploitative alliances in smart cities
Authors: Ferraris Alberto , Santoro Gabriele , Bresciani Stefano , Carayannis Elias G. 
Published: March 2018

PurposeThe purpose of this paper is to investigate how multinational enterprises (MNEs) manage human resources (HR) in explorative and exploitative alliances in smart city projects (SCPs).Design/methodology/approachIn this paper, the authors adopt an explorative and qualitative approach based on multiple case studies thanks to the interviews with 21 smart city managers of MNEs who are deeply involved in SCPs.FindingsThe authors found that MNEs use many different partnerships and “temporal separation” in many cities all around the world in order to maximize the benefits of both exploration and exploitation. According to the aim of the project, MNEs implemented different HR practices intentionally targeted toward managing social relations among internal and external employees involved in SCPs.Practical implicationsThe authors highlighted that MNEs tend to develop different ties among employees and external partners and to use different HR practices according to the nature and to the aim of the alliances. Thus, the development of human resource management systems becomes crucial in supporting organizational ambidexterity through alliances.Social implicationsThis paper gives useful insights in improving the effectiveness of MNEs in SCPs. Due to the business opportunities arising from the application of ICT and technological innovation to urban services, MNEs are becoming an important player in smart cities. Increasing the effectiveness of the SCPs leads faster to more economically, socially and environmentally sustainable cities.Originality/valueThe development of alliances has a key role in strengthening and complementing firms’ exploration and exploitation agendas in SCPs. Thus, this paper provides guidelines to MNEs in order to adapt HR practices and to rethink the role of HR within and across corporate boundaries in an emergent context of analysis.