bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of Myofascial Trigger Point Release on Power and Force Production in the Lower Limb Kinetic Chain
Authors: Devereux Frank , O'Rourke Brian , Byrne Paul J. , Byrne Damien , Kinsella Sharon 
Published: February 2018

Abstract
Devereux, F, O'Rourke, B, Byrne, PJ, Byrne, D, and Kinsella, S. Effects of myofascial trigger point release on power and force production in the lower limb kinetic chain. J Strength Cond Res 33(9): 2453–2463, 2019—The purpose of this study was to first investigate the effects of treating latent myofascial trigger points (MTrPs) in the lower limb kinetic chain with respect to performance during sporting actions, as opposed to the traditional goal of pain management with active MTrPs. The second aim was to investigate the effects of dry needling (DN) on performance parameters over time to establish treatment timeframe guidelines before performance. Forty male athletes were assigned to 4 groups; rectus femoris DN (group 1), medial gastrocnemius DN (group 2), rectus femoris and medial gastrocnemius DN (group 3), and no DN (group 4). Subjects completed 6 sessions; familiarization, baseline, immediately after DN, 48, 72, and 96 hours after intervention. Subjects performed squat jumps at 5 incremental loads and were recorded using the My Jump app (iOS) for jump height, power output, optimal force, and optimal velocity. A between–within subject's analysis of variance was used for statistical analysis. Results showed a significant increase in jump height in group 2 (gastrocnemius muscle only) from immediately after to 48 hours after intervention (p = 0.01); however, no other statistical significance was observed. From 48 hours onward, a trend for improved performance was observed, with jump height, power, and velocity showing trivial increases. This study found improved jump performance from immediately after to 48 hours post-DN of the gastrocnemius muscle only. This study suggests a likely immediate decrease in jump performance after DN, with levels increasing above baseline between 48 and 96 hours, which may have clinical significance.
Effect of a Hamstring Flexibility Program Performed Concurrently During an Elite Canoeist Competition Season
Authors: Álvarez-Yates Tania , García-García Oscar 
Published: February 2018

Abstract
Álvarez-Yates, T and García-García, O. Effect of a hamstring flexibility program performed concurrently during an elite canoeist competition season. J Strength Cond Res 34(3): 838–846, 2020—The aim of this study was to determine the acute effect of an 8-week specific hamstring flexibility training on junior canoeist during the competition season. Sixteen canoeists participated, divided into 3 groups: 5 in experimental group 1 (EG1), 5 in experimental group 2 (EG2), and 6 in a control group. The EG1 underwent a supervised program consisted by simple static stretching, dynamic static stretching, and proprioceptive neuromuscular facilitation (PNF), whereas the EG2 performed a program without PNF and no supervision. Two measurements were performed to analyze the effect on the knee joint range of motion (ROM) and trunk flexion; neuromuscular and contractile properties in biceps femoris (BF) and semitendinosus (ST) muscles; and maximum power and average speed in lower limbs. A mixed-design factorial analysis of variance (p ≤ 0.05) was performed and the effect size was calculated. The results show significant improvements (p ≤ 0.05) in both legs for knee joint ROM and trunk flexion in EG1 (8.9 and 25.5%; 5.7 and 20.9% in the right and left leg, respectively) and EG2 (6.7 and 22%; 3.9 and 24.4%), only EG1 improved muscular stiffness in BF (27.4% left leg) and ST (20.5 and 24.3%), and lateral symmetry in BF (49%) without decreasing average speed in lower limbs. All improvements have a large effect size. In conclusion, it is suggested that a supervised hamstring flexibility program performed concurrently during a canoeist competition season can produce an increase in the knee joint ROM and trunk flexion, without negative repercussions in contractile and neuromuscular capacities, maximum power, and average velocity in lower limbs.
Knowledge, Attitudes, and Beliefs of Youth Sports Coaches Regarding Sport Volume Recommendations and Sport Specialization
Authors: Post Eric G. , Trigsted Stephanie M. , Schaefer Daniel A. , Cadmus-Bertram Lisa A. , Watson Andrew M. , McGuine Timothy A. , Brooks Margaret Alison , Bell David R. 
Published: February 2018

AbstractPost, EG, Trigsted, SM, Schaefer, DA, Cadmus-Bertram, LA, Watson, AM, McGuine, TA, Brooks, MA, and Bell, DR. Knowledge, attitudes, and beliefs of youth sports coaches regarding sport volume recommendations and sport specialization.J Strength Cond Res34(10): 2911–2919, 2020—Overuse injuries in youth athletes are becoming increasingly common, which may be a result of the prevalence of year-round specialized sport participation. Previous research has identified sport volume recommendations related to months per year, hours per week, and simultaneous participation in multiple sports leagues. Coaches are a primary influence on a youth athlete's decision to specialize in a single sport. Therefore, identifying coaches' baseline beliefs and perceptions is important for developing strategies to educate coaches about safe sport participation. A total of 253 youth sport coaches (207 males) completed an anonymous online questionnaire regarding knowledge of sport volume recommendations and attitudes and beliefs regarding sport specialization. Eligible participants were required to serve as a head or assistant coach of a youth sport team in the past 12 months whose members were between the ages of 12 and 18 years. Most coaches were unaware of recommendations regarding the maximum number of months per year (79.4%), hours per week in 1 sport (79.3%), or number of simultaneous leagues for an athlete to participate in to reduce injury (77.6%). Fewer than half (43.2%) of all coaches were “very” or “extremely” concerned about the risk of injury in youth sports. A majority (60.1%) believed that sport specialization was either “quite a bit” or “a great deal” of a problem. Two-thirds (67.2%) responded that year-round participation in a single sport was either “very” or “extremely” likely to increase an athlete's risk of injury. Although the responses to this survey were predominantly from coaches from 1 state, our results suggest that coaches are unaware of sport volume recommendations but are concerned about specialization. Future efforts are needed to communicate these recommendations to coaches to reduce the risk of overuse injury in youth sports.
Effect of Caffeine Supplementation on Quadriceps Performance After Eccentric Exercise
Authors: Green Michael S. , Martin Tyler D. , Corona Benjamin T. 
Published: February 2018

Abstract
Green, MS, Martin, TD, and Corona, BT. Effect of caffeine supplementation on quadriceps performance after eccentric exercise. J Strength Cond Res 32(10): 2863–2871, 2018—Caffeine use is common among athletes seeking to capitalize on its potential ergogenic effects. Limited research has examined caffeine's effects when used after activities that resulted in exercise-induced muscle damage (EIMD). This study examined the effect of caffeine supplementation on uninjured and injured muscle. Eight men and women (N = 16) who were physically active individuals participated in this study (age: 24.3 ± 4.3 years; height: 173.0 ± 7.0 cm, mass: 75.2 ± 11.5 kg; body fat: 18.2 ± 15.9%). One leg was assessed under uninjured and injured (100 eccentric quadriceps contractions) conditions after caffeine supplementation (6 mg·kg−1), with the other leg assessed under both conditions after placebo supplementation. Compared with the placebo, caffeine increased peak isokinetic torque by 6.8 ± 2.3 and 9.4 ± 2.5% in uninjured and injured muscle, respectively, but had no effect on maximal voluntary isometric torque or fatigue index in uninjured or injured muscle, with treatments exhibiting similar (p > 0.05) alterations in isometric torque (−11.9 ± 2.2%), fatigue index (−13.9 ± 3.4%), and soreness (+44.0 ± 4.7) after eccentric contractions. The results of this study suggest that caffeine possesses a similar ergogenic effect on isokinetic torque in both uninjured and injured states, but no effect on the production of isometric torque, perception of soreness, or degree of relative fatigue. Athletes should consider the potential caffeine supplementation possesses during recovery from activities that resulted in EIMD.
Fractura por estrés del cuello del fémur en una niña hiperactiva tratada con metilfenidato. Reporte de caso. [Femoral neck stress fracture in a hyperactive child taking methylphenidate. Case report].
Authors: Grazina Rita , Portela Rafael , Martins Gustavo , Ferreira Andreia , Rodrigues Domingues , Santos Mafalda 
Published: February 2018

Las fracturas por estrés afectan, con mayor frecuencia, a personas físicamente activas con hueso normal y son infrecuentes en los niños con placa de crecimiento abierta. Aun más infrecuentes son las fracturas por estrés del cuello femoral en la población pediátrica. Sin embargo, constituyen entidades muy importantes debido al riesgo de complicaciones graves, como la necrosis avascular. Se describe el caso de una niña de 7 años medicada con metilfenidato que sufrió una fractura por estrés del cuello del fémur atípica. La paciente consulta por dolor inguinal derecho sin limitaciones en las actividades cotidianas. La radiografía muestra una fractura por estrés del cuello del fémur, que se confirma con tomografía. Se instaura un tratamiento conservador, y la paciente está asintomática a las cuatro semanas. Este caso representa una alerta sobre esta infrecuente entidad en la que podrían presentarse errores diagnósticos. Investigaciones recientes también sugieren la posible participación de fármacos, como el metilfenidato, en la desmineralización ósea, que podría constituir un posible factor de riesgo de fractura. AbstractStress fractures most commonly affect physically active individuals with normal bone, and they are rare in children with open growth plates. Even rarer are femoral neck stress fractures in pediatric age. Nevertheless, they constitute a very important entity due to the risk of severe complications, such as avascular necrosis. A seven-year-old girl, treated with methylphenidate, who suffered an atypical femoral neck stress fracture is presented. Patient complained of right inguinal pain without daily life activity limitations. The radiograph showed a stress femoral neck fracture, confirmed by CT imaging. Conservative treatment was instituted and the patient became asymptomatic after 4 weeks.This case report alerts the clinicians about this rare entity that might be misdiagnosed. Recent research also suggests a possible involvement of drugs, such as methylphenidate, in bone demineralization, which might constitute a possible risk factor for fractures.
A bélmikrobiom, a metabolikus betegségek és a hypertonia kapcsolatának irodalmi áttekintése
Authors: Barna István , Nyúl Dóra , Szentes Tamás , Schwab Richárd 
Published: February 2018

Abstract: Gut flora has personal characteristics for each individual, similar to the fingerprints, consisting of a special mixture of bacterial species living in the intestines, now referred to as the gut microbiome. There is a strong correlation between the loss of microbial diversity and the functional bowel disorders, obesity, type 2 diabetes and cardiovascular disease as well as many autoimmune disorders. With genetic testing of stool diversity of the gut microbiome and exact analysis of the species and phylogenetic classification of the gut flora, the changes of diversity can be identified and the overgrowth of some bacteria can be revealed. In cases with pre- and manifest hypertension, an overgrowth of species from the phylum Firmicutes has been reported along with the relative decline of the phylum Bacteroidetes as opposed with cases of normotension. At the same time, the physiological balance among bacterial families was lost. According to the first studies, there is a correlation between hypertension and the lost balance of the gut microflora, both in animal experiments and in the human clinical setting. This evidence also suggests that targeted dietary alteration of the gut microbiome can be a new innovative approach in the treatment of hypertension. Orv Hetil. 2018; 159(9): 346–351.
Fogazati rendellenességek kezelési szükségletének tárgyilagos felmérése a Dental Aesthetic Index segítségével
Authors: Pop Silvia Izabella , Mártha I. Krisztina , Csibi Réka , Păcurar Mariana , Minodora Ciotloș , Bratu Dana Cristina 
Published: February 2018

Abstract: Introduction and aim: To evaluate the frequency and severity of the malocclusions and treatment need in a group of adult patients in Târgu-Mureș, dividing them up according to age and gender. Method: Sixty-four, randomly selected patients were divided up according to age and gender. Ten occlusal traits related to dentofacial anomalies according to missing teeth, spacing, crowding and occlusion were used to evaluate the malocclusions on each of their study cast. The Dental Aesthetic Index (DAI) regression equation was used to obtain the DAI score that defines severity. Results: The average DAI score was 38 with a range of 18–79, showing that the majority of patients needed mandatory orthodontic treatment. No statistically significant difference was found between gender, age groups and need for treatment. Conclusion: More than two-fifths of the examined patients have a mandatory need for orthodontic treatment if the DAI scores are the main screening tool. Orv Hetil. 2018; 159(9): 352–356.
Az alacsony intenzitású, bizonyítottan hatékony kognitív viselkedésterápia Crohn-betegségben
Authors: Antal-Uram Dóra , Harsányi László , Perczel-Forintos Dóra 
Published: February 2018

Abstract: Inflammatory bowel disease (Crohn’s disease and colitis ulcerosa) is a chronic, long-term condition that causes chronic inflammation in the digestive tract, and shows an increasing incidence and prevalence worldwide. Changes in disease activity over time affect psychological distress which increases the risk of exacerbations. Beside somatic symptoms (such as abdominal pain, diarrhoea and weight loss), psychiatric comorbidity (in particular major depression, anxiety, social phobia) is common in patients with Crohn’s disease. This case study illustrates the management and stabilization of a 21-year-old adult male patient with active Crohn’s disease and with severe psychiatric comorbidity. The patient was diagnosed with avoidant personality disorder and dysruptive mood dysregulation disorder based on the results of psychodiagnostics (SCID-II structured clinical interview, MMPI personality inventory and disease-specific clinical questionnaires such as Beck Depression Inventory, Beck Hopelessness Scale, Social Cognition Questionnaire, Anger Expression Scale, Cognitive Emotion Regulation Questionnaire, Rosenberg Self-Esteem Scale). The main aim of psychotherapy is to increase the adherence to pharmacotherapy, to promote psychosocial functioning, to improve well-being and to enhance adaptive coping strategies. Low-intensity cognitive-behavioural psychotherapy was used which included psychoeducation, motivational interview, behavioural activation, patient diary, cognitive restructuring, problem-solving training, and family consulting. Twenty-five sessions were held weekly in outpatient form and 3 sessions of crisis intervention after the surgery at the hospital. The efficacy of the treatment was measured by self-reported questionnaires at baseline and at two follow-up sessions which corroborated a very significant decrease in the severity of depression, hopelessness, while emotional regulation and self-esteem became more adaptive. The remission of the above-mentioned psychiatric symptoms resulted in the improvement of the pharmacotherapy adherence and the quality of life. Low-intensity psychosocial interventions are proven to be an effective way of delivering evidence-based psychotherapy. Orv Hetil. 2018; 159(9): 363–369.
Utazás előtti tanácsadás és betegedukáció a magyar utazóknál
Authors: Lengyel Ingrid , Felkai Péter 
Published: February 2018

Abstract: Introduction: According to international surveys, over half of the travellers face some kind of health issue when travelling. The overwhelming majority of travel-related illnesses can be prevented with pre-travel medical consultations, but the syllabus and content of the consultation have to match the travel habits and culture of the given society. Aim: This publication explores the specificities and travel habits of Hungarian travellers. Method: One hundred participants of a travel exhibition completed a survey about their international travel. As the survey was not representative, the data could only be processed through simple statistical methods. However, since the exhibition was presumably attended by those wishing to travel, the conclusions drawn from the results are worth publishing, since no similar survey in Hungary has been published before. Results: Based on the suitable classification of age groups in travel medicine, 11% of the participants were adolescents / young adults (aged 15–24), 81% adults (25–59) and 8% elderly (60–74). Twenty-eight percent of the participants travel multiple times a year, 40% yearly and 32% of them less frequently; 16% of the adults, 8% of the adolescents and 4% of the elderly age group travel multiple times a year. Conclusions: The travel destinations of Hungarian travellers have remained practically unchanged since a study was conducted 13 years ago: the vast majority (95%) travelled within Europe, 2% to the United States, and 11% of them elsewhere. Since Hungarians do not travel to endemic areas, only 5% consulted their general practitioners (GPs) prior to travelling, and 29% did when they had to be vaccinated. Forty-two percent of those wishing to travel never consult their GPs, even though 29% of them are aware of some chronic illness. Instead, 51% gather their health information from the internet and only 6% from their doctors. By the contradiction between the poor health status of the majority of Hungarian travellers and the negligence of seeking pre-travel advice, our survey clearly points out the importance of the propagation of doctor’s advice before trips, even if the travellers visit exclusively non-endemic countries like the European Union. Orv Hetil. 2018; 159(9): 357–362.
Second-Line Treatment Landscape for Renal Cell Carcinoma: A Comprehensive Review
Authors: Tannir Nizar M. , Pal Sumanta K. , Atkins Michael B. 
Published: February 2018

Abstract

The management of advanced clear-cell renal cell carcinoma has steadily improved over the past decade with the introduction of antiangiogenic and targeted therapies. Recently, three new therapies have been approved for use as second-line options that further advance the treatment armamentarium: nivolumab, a monoclonal antibody targeting the programmed cell death receptor; cabozantinib, a small-molecule tyrosine kinase inhibitor (TKI) of vascular endothelial growth factor receptor (VEGFR), MET, and AXL; and lenvatinib, a small-molecule TKI of VEGF and fibroblast growth factor receptors that is used in combination with everolimus, an inhibitor of the mechanistic target of rapamycin. Together, these and previously approved second-line treatments offer clinicians the ability to better individualize treatment for patients after progression on first-line VEGFR-targeted therapies. In this comprehensive review, we discuss the efficacy and safety results from the pivotal trials of these newly approved therapies, including the quality of study design, the level of evidence, subgroup analyses, and how these data can help to guide clinicians to select the most appropriate second-line therapy for their patients.

Implications for Practice
This review article provides the reader with a comprehensive overview of current treatment options for patients with advanced clear-cell renal cell carcinoma (RCC) whose disease has progressed after their first therapy. As many patients with RCC experience disease progression with initial treatments, effective second-line therapies are critical. Nivolumab, cabozantinib, and lenvatinib plus everolimus have recently been approved as second-line treatments. The new agents discussed in this review increase the therapeutic options available and provide physicians with opportunities to individualize treatments for their patients, with a view to improving disease control and survival outcomes.
Development and evaluation of a rapid DNA preparation method for PCR-based DNA virus detection
Authors: Qu Tailong , Zhao Dun , Li Runcheng , Ge Meng , Yu Xinglong 
Published: February 2018

<p>We describe a simple, rapid and resource-saving method of DNA preparation from cultured cells, sera and animal tissues for PCR-based DNA virus detection. The method does not require the proteinase K, ethanol or phenol/chloroform used in conventional methods, and the entire procedure is performed in the same tube, reducing possible cross contamination between samples and the expense of laboratory ware. The protocol utilizes guanidine HCl and sodium dodecyl sulfate successively to lyse cells and dissociate proteins from nucleic acid at high temperature, and precipitates SDS and proteins at low temperature while reducing guanidine HCl concentration sufficiently to permit PCR-based virus detection. This method is extremely low cost, high sensitivity and provides a quick and effective way for clinical and laboratory virus detection, and is especially useful for simultaneous analysis of a large number of samples.</p>
Immunogold Nanoparticles Recognition imaging by Direct Atomic Force Microscopy
Authors: Cao Yang , Zhang Wenwen , Yang Pengfei , Zhang Liping , Li Lili , Zhao Xin , Li Jinke , Ma Xuezheng , Ping Ruijin , Hu Kongxin 
Published: February 2018

<p>We have developed a method that integrated the widely used nanogold immunoassay into direct atomic force microscopy (AFM) imaging and provided a specific morphological technique applying for virus identification. The series of specimens including bare gold particles (Au), antibody-conjugated gold particles (Au-Ab), purified influenza virions (H1N1), antibody-bound virions (H1N1-Ab) and virion-immunogold complex (H1N1- Ab-Au) were investigated by AFM and transmission electron microscopy stepwisely and parallelly. The recognition method of the immuno-AFM technique was constructed by taking the local phase contrast in phase image as main judgment for the existence of immunogold labels and taking the height and amplitude images as auxiliary judgment for viral morphology and positioning. The nanogold-antibody conjugates binding to the H1N1 virions were clearly identified as higher brightness spots from the background biomaterials. Under direct AFM, the topographical image of the scanned biosamples can be easily investigated and reproduced. Our findings achieved the combination of virus morphological features with antibody-antigen specific recognition through the application of antibody-specific nanogold labels and, in principle, the labels for immuno-AFM could be extended to other types of nanomaterials for bio-recognition and localization assay.</p>