bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pengaruh Senam Hipertensi untuk Upaya Penurunan Tekanan Darah pada Penderita Hipertensi di Posyandu Nusa Indah Desa Ngrombo
Authors: Aldiansa Prima , Muhlisin Abi 
Published: November 2024

ABSTRACT Hypertension is a condition where a person experiences an increase in blood pressure above normal. A person can develop hypertension if the systolic blood pressure is > 140 mmHg and diastolic pressure > 90 mmHg. One of the preventive efforts that can be done to avoid hypertension is to do sports such as anti-hypertensive gymnastics. The purpose of this study was to determine the effect of hypertension gymnastics on lowering blood pressure in hypertensive patients at posyandu nusa indah Ngrombo village, Baki. The research method used is to calculate pre and post hypertension gymnastics. The paired sample t-test results obtained þ- value = 0.000 < α = 0.05 so that H0 is rejected H1 is accepted. The results showed that the average systolic blood pressure before elderly hypertension gymnastics was 146.67mmHg, diastolic 91.67mmHg and the average systolic blood pressure after elderly hypertension gymnastics was 135.42 mmHg, diastolic 88.17 mmHg. It can be concluded that there is an effect of hypertension exercise on reducing systolic and diastolic blood pressure in hypertension sufferers at Posyandu Nusa Indah, Ngrombo, Baki District. Keywords: Hypertension Exercise, Hypertension, Blood Pressure ABSTRAK Hipertensi merupakan suatu kondisi dimana seseorang mengalami peningkatan tekanan darah diatas normal. Seseorang dapat terkena hipertensi apabila tekanan darah sistolik >140 mmHg dan tekanan diastolic >90 mmHg. Salah satu upaya pencegahan yang dapat dilakukan untuk menghindari terjadinya hipertensi ialah dilakukan dengan melakukan olahraga seperti senam anti hipertensi. Tujuan penelitian ini adalah untuk mengetahui pengaruh diberikan senam hipertensi terhadap penurunan tekanan darah pada penderita hipertensi di posyandu nusa indah desa Ngrombo, Baki. Metode penelitian yang digunakan yaitu dengan menghitung pre dan post senam hipertensi. Hasil uji paired sample t-test didapatkan þ- value= 0,000 < α=0,05 sehingga H0 ditolak H1 diterima. Hasil penelitian menunjukkan rata-rata tekanan darah sistolik sebelum senam hipertensi lansia 146.67mmHg, diastolik 91.67mmHg dan rata-rata tekanan darah sistolik sesudah senam hipertensi lansia 135.42 mmHg, diastolik 88.17 mmHg. Dapat disimpulkan terdapat pengaruh senam hipertensi terhadap penurunan tekanan darah sistolik dan diastolic pada penderita hipertensi di Posyandu Nusa Indah Desa Ngrombo, Kecamatan Baki. Kata Kunci: Senam Hipertensi, Hipertensi, Tekanan Darah
Hubungan Antara Intensitas Olahraga dengan Kualitas Tidur pada Mahasiswa/I Fakultas Kedokteran Universitas Tarumanagara Angkatan 2021-2022
Authors: Razaan Muhammad Naufal , Lontoh Susy Olivia 
Published: November 2024

ABSTRACT The quality of sleep in medical students is susceptible to decreasing due to the shorter quantity of sleep time. The busy study schedule of students, especially medical faculties, exposes them to an increased risk of various sleep problems and their consequences. Poor sleep quality is associated with anxiety and depression, and can interfere with learning and academic achievement. Sleep quality can be improved one way by doing physical activity. The purpose of this research is to determine the relationship between exercise intensity and sleep quality in Tarumanagara University medical students class 2021 -2022. This type of research uses a cross-sectional design and analytical observational study with total of 100 students. The research was conducted at Tarumanagara University in January 2024 – June 2024 and was carried out by distributing a google form. Incorporation criteria of this research are students from the Faculty of Medicine Tarumanagara University class 2021-2022 who were in good health and willing to be respondents.The results showed that there is a significant relationship between exercise intensity and sleep quality in students from the Faculty of Medicine, Tarumanagara University class of 2021-2022 with p value = 0,024 (p<0,05). This shows that students' sleep quality can be improved with physical activity. Keywords: Exercise intensity, Sleep Quality, Exercise, Sleep ABSTRAK Kualitas tidur pada mahasiswa kedokteran rentan menurun akibat kuantitas waktu tidur yang lebih singkat. Padatnya jadwal belajar mahasiswa, khususnya fakultas kedokteran, membuat mereka rentan terhadap peningkatan risiko berbagai masalah tidur dan dampaknya. Kualitas tidur yang buruk dikaitkan dengan kecemasan dan depresi, serta dapat mengganggu pembelajaran dan prestasi akademik. Salah satu cara untuk meningkatkan kualitas tidur adalah dengan meningkatkan aktivitas fisik. Tujuan penelitian ini adalah untuk mengetahui hubungan intensitas olahraga dengan kualitas tidur pada mahasiswa Kedokteran Universitas Tarumanagara angkatan 2021 -2022. Jenis penelitian ini menggunakan desain cross-sectional dan studi observasional analitik dengan jumlah peserta didik sebanyak 100 orang. Penelitian dilakukan di Universitas Tarumanagara pada bulan Januari 2024 – Juni 2024 dan dilakukan dengan menyebarkan google form. Kriteria inklusi penelitian ini adalah mahasiswa Fakultas Kedokteran Universitas Tarumanagara angkatan 2021-2022 yang dalam keadaan sehat dan bersedia menjadi responden. Hasil penelitian menunjukkan bahwa terdapat hubungan yang signifikan antara intensitas olahraga dengan kualitas tidur pada mahasiswa Fakultas Kedokteran Universitas Tarumanagara angkatan 2021-2022 dengan p value = 0,024 (p<0,05). Hal ini menunjukkan bahwa kualitas tidur mahasiswa/i dapat ditingkatkan dengan aktivitas fisik. Kata Kunci: Intensitas Olahraga, Kualitas Tidur, Olahraga,Tidur
Hubungan Kadar Sebum pada Penderita Akne Vulgaris di SMAN 75 Jakarta Utara
Authors: Fadhila Arni Ismi , Tan Sukmawati Tansil 
Published: November 2024

ABSTRACT Acne Vulgaris (AV) is a chronic inflammatory skin disease affecting the pilosebaceous glands. Acne Vulgaris commonly occurs in adolescents due to hormonal fluctuations that stimulate the sebaceous glands to produce more sebum. The face, back, chest, and shoulder areas often display a predilection for AV. The aim of this study is to assess the facial sebum levels of students at SMAN 75 North Jakarta predisposed to acne vulgaris. This study used a cross-sectional design and was conducted at SMAN 75 North Jakarta in January 2024. Sampling was carried out using non-random consecutive sampling. Data obtained from the samples will be processed and analyzed using SPSS 22.0. Sebum levels were measured using a skin analyzer SK-08 on the left and right sides of the face. The characteristics of the AV group in students of SMAN 75 North Jakarta showed severe acne as many as 37 people (8.20%), moderate acne as many as 100 people (6.57%), and mild acne as many as 33 people (5.75%). Based on the Kruskal-Wallis statistical test, there was a significant difference in the average oil content between the three acne severity groups (P-value <0.001). These results indicate that increased sebum levels are associated with increased severity of acne vulgaris. Keywords: Acne Vulgaris, Sebum Levels, Pilosebasea Glands, Skin Analyzer ABSTRAK Akne Vulgaris (AV) adalah penyakit kulit inflamasi kronis yang menyerang kelenjar pilosebasea. Akne Vulgaris umumnya terjadi pada remaja akibat fluktuasi hormonal yang merangsang kelenjar sebasea untuk memproduksi lebih banyak sebum. Area wajah, punggung, dada, dan bahu sering menunjukkan kecenderungan AV. Tujuan dari penelitian ini adalah untuk menilai kadar sebum wajah siswa di SMAN 75 Jakarta Utara yang rentan terhadap akne vulgaris. Penelitian ini menggunakan desain cross-sectional dan dilakukan di SMAN 75 Jakarta Utara pada bulan Januari 2024. Pengambilan sampel dilakukan dengan menggunakan non-random sequential sampling. Data yang diperoleh dari sampel akan diolah dan dianalisis menggunakan SPSS 22.0. Kadar sebum diukur menggunakan skin analyzer SK-08 pada sisi kiri dan kanan wajah. Karakteristik kelompok AV pada siswa/i SMAN 75 Jakarta Utara menunjukkan Akne berat sebanyak 37 orang (8,20%), akne sedang sebanyak 100 orang (6,57%), dan akne ringan sebanyak 33 orang (5,75%). Berdasarkan uji statistik Kruskal-Wallis, terdapat perbedaan signifikan rata-rata kadar minyak di antara ketiga kelompok tingkat keparahan akne (P-value <0,001). Hasil ini menunjukkan bahwa peningkatan kadar sebum berhubungan dengan peningkatan keparahan akne vulgaris. Kata Kunci: Akne Vulgaris, Kadar Sebum, Kelenjar Pilosebasea, Skin Analyzer
Global Trends in Research on Microplastic Contamination and River Water Quality: A Bibliometric Review
Authors: Eriana Nisa Nur Agistni , Kania Nia , Noor Meitria Syahadatina , Suhartono Eko , Herawati Herawati 
Published: November 2024

ABSTRACT This study aims to analyse global trends in research related to microplastic contamination and river water quality using a bibliometric approach. Microplastics have become one of the most pressing environmental issues in recent decades, mainly due to their significant impact on aquatic ecosystems and potential harm to human health. Along with the increasing attention to this issue, the scientific literature related to microplastics and river water quality has grown rapidly. However, a thorough understanding of the distribution of research, relationships between topics, as well as potential research gaps is still needed to direct future research more effectively. This study used a literature search method through the Publish or Perish app, with keywords including "microplastics," "water quality," "water pollution," "microplastic contamination," and "river." The search was conducted from 2014 to 2024, resulting in 50 relevant articles for further analysis. The data obtained was then processed using VOSviewer to map and visualise the bibliometric network, identify key clusters, and evaluate the temporal progression of these research topics. The resulting visualisations, including network visualisation, overlay visualisation, and density visualisation, provide deep insights into how key terms are connected and evolve in the literature. The analysis showed that research on microplastics in the context of rivers and water quality is heavily dominated by a few key terms such as "microplastic," "river," and "water," indicating the high level of scientific attention on this topic. In addition, it was found that research often focuses on the distribution of microplastics, physicochemical parameters of water, and sources of contamination. However, there are some significant research gaps, especially related to the effect of salinity on microplastic distribution, the accumulation of microplastics in river sediments, and the role of wastewater treatment plants in preventing the spread of microplastics to aquatic ecosystems. The conclusion of this study is that despite significant progress in understanding the distribution and impacts of microplastics, many aspects still require further research. In particular, research on the long-term impacts of microplastics and their interactions with other environmental components should be further enhanced. The findings are expected to provide guidance for future researchers to explore under-explored areas and contribute to better environmental management. Keywords: Microplastic, Water Quality, River Pollution, Bibliometric Analysis, Environmental Research
Multiple factors regulate the expression of sufCDSUB in Streptococcus mutans
Authors: Ellepola Kassapa , Guillot Lauren C. , Comeaux Bradley , Han Yiran , Kajfasz Jessica K. , Bitoun Jacob P. , Spatafora Grace , Lemos Jose A. , Wen Zezhang T. 
Published: November 2024

IntroductionThe sufCDSUB gene cluster, encoding the sole iron-sulfur (Fe-S) cluster assembly system in S. mutans, was recently shown to be up-regulated in response to oxidative stressors and Fe limitation.MethodsIn this study, luciferase reporter fusion assays, electrophoretic gel mobility shift assays (EMSA) and in vitro transcription assays (IVT) were used to dissect the cis- and trans-acting factors that regulate the expression of sufCDSUB.Results and discussionResults showed deletion of perR, for the only Fur-family transcriptional regulator in S. mutans, resulted in &gt;5-fold increases in luciferase activity under the control of the sufCDSUB promoter (P&lt;0.01), as compared to the parent strain, UA159 when the reporter strains were grown in medium with no supplemental iron. Site-directed mutagenesis of a PerR-box in the promoter region led to elevation of the reporter activity by &gt;1.6-fold (P&lt;0.01). In an EMSA, recombinant PerR (rPerR) was shown to bind to the cognate sufCDSUB promoter leading to mobility retardation. On the other hand, the reporter activity was increased by &gt;84-fold (P&lt;0.001) in response to the addition of cysteine at 4 mM to the culture medium. Deletion of cysR, for a LysR-type of transcriptional regulator, led to reduction of the reporter activity by &gt;11.6-fold (P&lt;0.001). Addition of recombinant CysR (rCysR) to an EMSA caused mobility shift of the sufCDSUB promoter probe, indicative of rCysR-promoter interaction, and rCysR was shown to enhance sufC transcription under the direction of sufCDSUB promoter in vitro. These results suggest that multiple factors are involved in the regulation of sufCDSUB expression in response to environmental cues, including cysteine and Fe availability, consistent with the important role of sufCDSUB in S. mutans physiology.
ECG analysis of ventricular fibrillation dynamics reflects ischaemic progression subject to variability in patient anatomy and electrode location
Authors: Martinez-Navarro Hector , Bertrand Ambre , Doste Ruben , Smith Hannah , Tomek Jakub , Ristagno Giuseppe , Oliveira Rafael S. , Weber dos Santos Rodrigo , Pandit Sandeep V. , Rodriguez Blanca 
Published: November 2024

BackgroundVentricular fibrillation (VF) is the deadliest arrhythmia, often caused by myocardial ischaemia. VF patients require urgent intervention planned quickly and non-invasively. However, the accuracy with which electrocardiographic (ECG) markers reflect the underlying arrhythmic substrate is unknown.MethodsWe analysed how ECG metrics reflect the fibrillatory dynamics of electrical excitation and ischaemic substrate. For this, we developed a human-based computational modelling and simulation framework for the quantification of ECG metrics, namely, frequency, slope, and amplitude spectrum area (AMSA) during VF in acute ischaemia for several electrode configurations. Simulations reproduced experimental and clinical findings in 21 scenarios presenting variability in the location and transmural extent of regional ischaemia, and severity of ischaemia in the remote myocardium secondary to VF.ResultsRegional acute myocardial ischaemia facilitated re-entries, potentially breaking up into VF. Ischaemia in the remote myocardium modulated fibrillation dynamics. Cases presenting a mildly ischaemic remote myocardium yielded sustained VF, enabled by the high proliferation of phase singularities (PS, 11–22) causing remarkably disorganised activation patterns. Conversely, global acute ischaemia induced stable rotors (3–12 PS). Changes in frequency and morphology of the ECG during VF reproduced clinical findings but did not show a direct correlation with the underlying wave dynamics. AMSA allowed the precise stratification of VF according to ischaemic severity in the remote myocardium (healthy: 23.62–24.45 mV Hz; mild ischaemia: 10.58–21.47 mV Hz; moderate ischaemia: 4.82–11.12 mV Hz). Within the context of clinical reference values, apex-anterior and apex-posterior electrode configurations were the most discriminatory in stratifying VF based on the underlying ischaemic substrate.ConclusionThis in silico study provides further insights into non-invasive patient-specific strategies for assessing acute ventricular arrhythmias. The use of reliable ECG markers to characterise VF is critical for developing tailored resuscitation strategies.
Late initiation of antenatal care and associated factors among pregnant women attending antenatal clinic at Hiwot Fana Comprehensive Specialized Hospital, Eastern Ethiopia: a cross-sectional study
Authors: Dibaba Bayisa , Bekena Miressa , Dingeta Tariku , Refisa Eshetu , Bekele Habtamu , Nigussie Shambel , Amentie Eyobel 
Published: November 2024

BackgroundLate initiation of antenatal care (ANC) is a major public health concern. If women initiate ANC late, they do not get adequate care, reducing the chances of early detection of pregnancy-related complications. However, there is a lack of data related to the initiation of antenatal care in the study area.ObjectivesTo assess the prevalence of late initiation of antenatal care and identify associated factors among pregnant women attending antenatal care at Hiwot Fana Comprehensive Specialized Hospital, Eastern Ethiopia.MethodsAn institutional-based cross-sectional study design was conducted among 454 pregnant women. All eligible participants during the study period were included. Data were collected via face-to-face interviews, were entered into Epi Data version 4.3, and analyzed using SPSS version 22 software. The results are presented using texts and tables. Logistic regression with the 95% confidence interval (CI) was used to identify factors associated with the late initiation of antenatal care. Statistical significance was declared at P &lt; 0.05.ResultsThe prevalence of late-initiation antenatal care in this study was 59.5% (95% CI 54.6–63.4). Age range of 30–34 years [adjusted odds ratio (AOR) 2.7, 95% CI 1.69–13.1] and age ≥35 years (AOR 4.2, 95% CI 1.92–9.84), rural residency (AOR 2.92, 95% CI 1.59–5.39), unplanned pregnancy (AOR 2.3, 95% CI 1.35–8.11), inability to make the decision to start ANC (AOR 2.14, 95% CI 1.18–3.89), multigravidity (AOR 1.9, 95% CI 1.13–12.4), wrong perception on the time of antenatal care initiation (AOR 5.8, 95% CI 3.71–9.34), lack of previous ANC experience (AOR 2.01, 95% CI 1.14–5.81), and more than 10 km distance from the hospital (AOR 1.36, 95% CI 0.62–2.95) were associated with late initiation antenatal care in this study.ConclusionMore than half of the study participants were initiated into ANC after the 12th week of gestation. Moreover, rural residence, unplanned pregnancy, age ≥30 years, lack of previous antenatal care, inability to make decisions, and wrong perception on the time of initiation of ANC were found to be associated with late initiation of ANC. Educating women and involving partners and family members in discussions about ANC were recommended to build a supportive environment for pregnant mothers.
Checkpoint based immunotherapy in non-small cell lung cancer: a real-world retrospective study
Authors: Liguori Luigi , Giorgio Gabriele , Polcaro Giovanna , Pagliara Valentina , Malandrino Domenico , Perri Francesco , Cascella Marco , Ottaiano Alessandro , Conti Valeria , Servetto Alberto , Bianco Roberto , Pepe Stefano , Sabbatino Francesco 
Published: November 2024

IntroductionImmune checkpoint inhibitor (ICI)-based immunotherapy targeting programmed cell death 1 (PD-1) or its ligand 1 (PD-L1) has radically changed the management of many types of solid tumors including non-small cell lung cancer (NSCLC). Many clinical trials have demonstrated that ICIs improve the survival and the quality of life of patients with advanced non oncogene NSCLC as compared to standard therapies. However, not all patients achieve a clinical benefit from this immunotherapeutic approach. As a result, real-word validation of the efficacy and safety of ICIs can be useful for defining potential predictive biomarkers as well as for overcoming limitations linked to clinical trial restrictions.MethodsWe retrospectively retrieved the clinical data of patients with advanced non oncogene NSCLC treated with ICIs (anti-PD-1 or anti-PD-L1) as single agent or in combination with chemotherapy at “San Giovanni di Dio e Ruggi D’Aragona” University Hospital from January 2016 to December 2023. Potential correlations between clinical-pathological characteristics and safety or survival outcomes were investigated employing the Fisher’s exact test, Mann-Whitney U test, the Kruskal-Wallis method and log-rank test, as applicable. Multivariate survival analyses were performed using the Cox proportional hazards model.ResultsClinical data of 129 patients were retrieved. At a median follow-up of 29.70 months, progression-free survival (PFS) and overall survival (OS) were 5.27 months and 8.43 months, respectively. At the multivariate analyses, smoking status, presence of bone metastases and the occurrence of immune-related adverse events (irAEs) were correlated with both PFS and OS. Moreover, patients treated with anti-PD-1-based therapy achieved an increased clinical benefit than those treated with anti-PD-L1.DiscussionIn this study we described our real-world experience of ICIs for the treatment of patients with advanced non oncogene NSCLC. A decreased OS in our study population was reported as compared to that of patients included in the clinical trials. Noteworthy, correlations between clinical-pathological characteristics and survival outcomes emerged. Nevertheless, the potential integration of clinical-pathological characteristics as predictive biomarkers in more accurate therapeutic algorithms as well as the underlying biological mechanisms should be further validated in ad hoc studies.
The circadian clock gene BMAL1 modulates autoimmunity features in lupus
Authors: Nakabo Shuichiro , Sandoval-Heglund Donavon , Hanata Norio , Brooks Stephen , Hoffmann Victoria , Zhang Mingzeng , Ambler William , Manna Zerai , Poncio Elaine , Hasni Sarfaraz , Islam Shamima , Dell’Orso Stefania , Kaplan Mariana J. 
Published: November 2024

ObjectivesAn important pathogenic role for neutrophils in systemic lupus erythematosus (SLE) has been proposed. Neutrophils that lack brain and muscle aryl hydrocarbon receptor nuclear translocator-like 1 (Bmal1), one of the clock genes, are defective in aging and proinflammatory responses. We assessed the role of Bmal1 in clinical and immunologic manifestations of murine lupus and in human SLE neutrophils.MethodsMyeloid-conditional Bmal1 knockout mice (Bmal1Mye−/−) and wild type (WT) were treated with epicutaneous TLR7/8 agonist (imiquimod; IMQ) for 6 weeks to induce a lupus phenotype. Upon euthanasia, immune responses, autoantibodies and renal manifestations were evaluated. NET formation and gene expression of bone marrow (BM)-derived murine neutrophils were evaluated. BMAL1 expression was quantified in SLE neutrophils and compared with clinical disease.ResultsIMQ-treated Bmal1Mye−/− and WT displayed comparable systemic inflammation. While renal function did not differ, serum anti-dsDNA levels and renal immune complex deposition were significantly increased in Bmal1Mye−/−. While no differences were observed in NET formation, expression levels of April in BM neutrophils were significantly higher in Bmal1Mye−/−. Bulk RNA-sequence data showed that BM neutrophils in IMQ-treated Bmal1Mye−/− were relatively immature when compared with IMQ-treated WT. BM showed an enhanced April protein expression in Bmal1Mye−/− mice. BMAL1 levels in human SLE peripheral blood neutrophils correlated positively with serum C3 and negatively with serum anti-dsDNA levels.ConclusionBmal1 is associated with lower disease activity in SLE. These results indicate that perturbation in the circadian rhythm of neutrophils can have pathogenic consequences in SLE.