bluuebunny/crossref_metadata_2025_split huggingface dataset:
Machine Learning Models for Genetic Risk Assessment of Infants with Non-Syndromic Orofacial Cleft
Authors: Zhang Shi-Jian , Meng Peiqi , Zhang Jieni , Jia Peizeng , Lin Jiuxiang , Wang Xiangfeng , Chen Feng , Wei Xiaoxing 
Published: December 2018

Abstract
The isolated type of orofacial cleft, termed non-syndromic cleft lip with or without cleft palate (NSCL/P), is the second most common birth defect in China, with Asians having the highest incidence in the world. NSCL/P involves multiple genes and complex interactions between genetic and environmental factors, imposing difficulty for the genetic assessment of the unborn fetus carrying multiple NSCL/P-susceptible variants. Although genome-wide association studies (GWAS) have uncovered dozens of single nucleotide polymorphism (SNP) loci in different ethnic populations, the genetic diagnostic effectiveness of these SNPs requires further experimental validation in Chinese populations before a diagnostic panel or a predictive model covering multiple SNPs can be built. In this study, we collected blood samples from control and NSCL/P infants in Han and Uyghur Chinese populations to validate the diagnostic effectiveness of 43 candidate SNPs previously detected using GWAS. We then built predictive models with the validated SNPs using different machine learning algorithms and evaluated their prediction performance. Our results showed that logistic regression had the best performance for risk assessment according to the area under curve. Notably, defective variants in MTHFR and RBP4, two genes involved in folic acid and vitamin A biosynthesis, were found to have high contributions to NSCL/P incidence based on feature importance evaluation with logistic regression. This is consistent with the notion that folic acid and vitamin A are both essential nutritional supplements for pregnant women to reduce the risk of conceiving an NSCL/P baby. Moreover, we observed a lower predictive power in Uyghur than in Han cases, likely due to differences in genetic background between these two ethnic populations. Thus, our study highlights the urgency to generate the HapMap for Uyghur population and perform resequencing-based screening of Uyghur-specific NSCL/P markers.
THE CATHOLIC CHURCH TESTED FOR CONFESSIONALISM: THE VATICAN II DOCTRINAL PRINCIPLES
Authors: Visioli Matteo 
Published: December 2018

AbstractIn Catholic doctrine, church and state are two different and autonomous institutional subjects, but they are mutually linked. Therefore, a believer, as a citizen, is a subject simultaneously of two legal systems; the state is bound to recognize the confessional dimension of its own members, and the church is called to realize its proper ends within a precise political-social context. The Second Vatican Council (1962–1965) constitutes for the Catholic Church a point of change and renewal. It did not limit itself to affirming the coexistence of the two systems in their independence, but it declared the necessity of a mutual alliance for the good of citizens and believers.Therefore, the church offers its own contribution to the state, favoring in this way the right to religious liberty; and the state allows the church to establish itself and carry out its proper mission in an institutional form, guaranteeing the protection of the rights of citizens as believers for the free expression of their faith, whether in a private dimension or in an organized form. Vatican II abandons, therefore, the concept of “state religion” in the classic sense of the term, and thus the privilege reserved to one among numerous religious expressions, and opens an authentic collaboration between parties as a prerequisite for the good not only for individual believers and religious organizations, but also for society itself. In particular, religious liberty finds its foundation no longer in the concept of truth (that legitimized the exclusion of other confessions in that they were “not true”), but in the concept of the dignity of the person, which must be protected as such.
THE (NOT SO) EXCEPTIONAL ESTABLISHMENT CLAUSE OF THE UNITED STATES CONSTITUTION
Authors: Scharffs Brett G. 
Published: December 2018

ABSTRACTSince the end of World War II and the beginning of the human rights era, a common narrative has dominated international discussions of law and religion, especially in Europe, that emphasizes the alleged idiosyncrasy and uniqueness of U.S. Constitutional law regarding freedom of religion. What I call the “standard story” notes that unlike human rights instruments, and the constitutions of most European States, the U.S. Constitution contains an “Establishment Clause” prohibiting an establishment of religion, while European countries do not have prohibitions on state establishments, and indeed the relationships between religion and the state fall along a continuum running from cooperation, favored religions, to actual state establishments of religion. According to the standard story, the Free Exercise Clause of the U.S. First Amendment is a precursor of and has analogues in the human rights instruments’ provisions protecting freedom of thought, conscience, and religion, but the Establishment Clause is characterized as being sui generis, a thing unto itself. The U.S. experience with the antiestablishment principle, symbolized by Jefferson's wall of separation, the standard story notes, is so unique and so different that the lessons gleaned there have very little to offer Europe, or indeed perhaps the rest of the world. In this article I argue, as my title suggests, that the American experience is not as unique as some (especially Europeans) sometimes think it is.
Combining efficiency and innovation to enhance performance: Evidence from firms in emerging economies
Authors: Tian Xiaowen , Lo Vai Io , Zhai Xiaoxuan 
Published: December 2018

AbstractThis paper extends the resource-capability-based view in strategic management and discusses the capabilities for the firms to stay competitive in emerging economies. Faced with low levels of efficiency, technology, and skills, firms in emerging economies need to implement best management practices to overcome operational inefficiency while engage in innovation processes to address new opportunities. They have to develop the capabilities to enhance efficiency, the capabilities to undertake innovation, and the synthesis capabilities to combine the two to keep rivals at bay. The paper tests hypotheses against a data set of more than 20,000 firms from 36 emerging economies provided by the World Bank in 2012–2015 and finds strong evidence to support the arguments. The paper finds that the three sets of capabilities are positively related to productivity and, through it, financial performance.
Fiscal difficulties of cities, the labor market, and health care
Authors: Hsu John , Newhouse Joseph , Overhage Lindsay Nicole , Zuvekas Samuel 
Published: December 2018

AbstractWe investigated labor force and health outcomes in cities experiencing fiscal difficulties to assess how those difficulties might impact their employees. We matched 23 cities with bond downgrades and 31 cities with stable bond ratings to sampling units in the Medical Expenditure Panel Survey. Starting the year before the downgrade and for the four subsequent years, the rate of separation from local public employment fell in the cities with downgrades relative to the comparison group. Self-reported health may have worsened, but there were no statistically significant effects on health care use or spending.
The effectiveness of CBT training on service delivery systems: a benchmarking study
Authors: Hadden L.M. , Groom M. , Waddington L. 
Published: December 2018

AbstractWales has not adopted the English IAPT system and has no centralized training plan for developing cognitive behavioural therapy (CBT) in Wales. However, Welsh Government policy expresses an ambition to improve access to evidence-based psychological therapies for people in Wales. This study focuses on one Welsh Health Board's plan to improve access to CBT. The study aims to benchmark support for effective delivery of CBT in the Health Board against NICE and Department of Health standards, and to establish whether the Health Board's plan is succeeding in developing staff capability and access to evidence-based CBT. Mental health staff funded by the Health Board to complete accredited training in CBT were asked to complete an online questionnaire asking about their training, accreditation, use of CBT, and experience of workplace support for delivering CBT. The standards were taken from the Department of Health competency framework for CBT, NICE guidelines and BABCP safety and confidentiality criteria. The Health Board performed well across seven standards of workplace support for the delivery of evidence-based CBT. Staff funded to undertake accredited CBT training continued to develop and to use CBT in their everyday clinical practice. The study indicates that the Health Board is succeeding in offering good standards of workplace support for CBT, including access to accredited CBT training. A recommendation is made that this be shared with other Welsh Health Boards and that a comparable study be undertaken within an IAPT service.
Confirmatory Factor Analysis of the Center for Epidemiologic Studies	Depression Scale in Oncology With Examination of Invariance Between Younger and	Older Patients
Authors: Saracino Rebecca M. , Cham Heining , Rosenfeld Barry , Nelson Christian J. 
Published: December 2018

Abstract. Accurate measurement of depressive symptoms in the cancer setting is critical for ensuring optimal quality of life and patient outcomes. The present study compared the one-factor, correlated two-factor, correlated four-factor, and second-order factor models of the Center for Epidemiologic Studies Depression Scale (CES-D), a commonly used measure in oncology settings. Given the importance of adequate psychometric performance of the CES-D across age groups, a second aim was to examine measurement invariance between younger and older adults with cancer. Participants ( N = 663) were recruited from outpatient clinics at a large cancer center. Over one-fourth of the sample endorsed clinically significant depressive symptoms (25.9%, n = 165). Confirmatory factor analysis of the CES-D supported the hypothesized correlated four-factor model as the best fit. The second-order factor also demonstrated good fit, but interpretations of the factors were more complex. Factors were highly correlated (range = .38–.91). There was also support for full scalar invariance between age groups, suggesting that regardless of age, respondents endorse the same response category for the same level of the latent trait (i.e., depression) on the CES-D. Taken together, the results suggest that the CES-D is a viable depression screening option for oncology settings and does not require scoring adjustments for respondent age.
Die laparoskopische Nierenteilresektion ohne
Ischämie
Authors: Imkamp Florian , Stickdorn Sabrina 
Published: December 2018

ZusammenfassungDie Nierenteilresektion ist seit Jahrzehnten ein etabliertes Verfahren, um
Nierentumoren zu therapieren. Studien zeigen, dass der Organerhalt bei einer
Nierentumoroperation zumeist mit einem besseren Gesamtüberleben im Vergleich zur
Nierenentfernung (Nephrektomie) verbunden ist. Im OP-Ablauf stellen wir die
minimalinvasive Nierenteilresektion vor, die inzwischen seit zwei Jahrzehnten
durchgeführt wird.
Understanding State-Level Variations in the US Infant Mortality: 2000 to 2015
Authors: Ebrahimvandi Alireza , Hosseinichimeh Niyousha , Iams Jay 
Published: December 2018

Objective To exploit state variations in infant mortality, identify diagnoses that contributed to reduction of the infant mortality rate (IMR), and examine factors associated with preterm-related mortality rate (PMR).
Study Design Using linked birth-infant deaths files, we examined patterns in the leading causes of IMR. We compared these rates at both national and state levels to find reduction trends. Creating a cross-sectional time series of states' PMR and some explanatory variables, we implemented a fixed-effect regression model to examine factors associated with PMR at the state level.
Results We found substantial state-level variations in changes of the IMR (range =  − 2.87–2.08) and PMR (−1.77–0.67). Twenty-one states in which the IMR declined more than the national average of 0.99 (6.89–5.90) were labeled as successful. In the successful states, we found reduction in the PMR accounted for the largest decline in the IMR—0.90 fewer deaths. Changes in the other subgroups of leading causes did not differ significantly in successful and unsuccessful states.
Conclusion Trends in the causes of mortality are heterogeneous across states. Although its impact is not large, reducing the percentage of pregnant women with inadequate care is one of the mechanisms through which the PMR decrease.
The Association between Oxidative Stress and Cardiac Functions in Infants Born to Preeclamptic Mothers
Authors: Arman Didem , Ercin Secil , Topcuoğlu Sevilay , Kaya Ayşem , Yavuz Taner , Karatekin Güner , Ovalı Fahri 
Published: December 2018

Objective The present study aimed to assess the global oxidant and antioxidant status in infants born to preeclamptic mothers and their correlation with cardiac functions.
Study Design We compared 40 infants born to preeclamptic mothers with 40 premature infants born to normotensive mothers. We assessed the relationship between echocardiographic measurements and total antioxidant capacity (TAC) and total oxidant status (TOS) values.
Results In the study group, TAC, TOS, and oxidative stress index (OSI) levels were significantly higher in the cord blood (p = 0.03, 0.04, and 0.039, respectively) than in the control group. We did not observe any correlation between echocardiographic measurements and TAC, TOS, and OSI levels in infants born to preeclamptic mothers.
Conclusion Compared with the control group, despite higher TAC levels in infants born to preeclamptic mothers, concurrent elevated OSI levels reveal that the oxidant–antioxidant balance is disturbed in favor of oxidants. Furthermore, the findings of this study suggest that echocardiographic parameters are unaffected by the oxidant status.
Reflection on Assessing the Development of Children after Epilepsy Surgery
Authors: Jennekens-Schinkel Aag , van Schooneveld Monique 
Published: December 2018

AbstractChildren of schoolage having similar medical and neuropsychological conditions but entirely different life courses after left-sided hemispherectomy led us to reflect on sources of differences in development after epilepsy surgery. Two recent reviews exposed the impact of epilepsy-related variables on the cognitive outcomes and concluded that overall the surgical procedures had not caused additional harm. Our aim was to see whether facilitating or impeding influences—other than epilepsy and epilepsy surgery—were addressed in the literature regarding cognitive outcome. Further review of the literature did not yield information on influences of variables that are known to affect normal development; no study addressed influences of motor and/or sensory impairments. Few studies discussed interference of deficits in other cognitive domains with the target domains. The influences of gender and of an important environmental aspect, family factors, etc., were underexposed as well. Understanding why one child adjusts to her/his novel life situation and another child with apparently similar abilities and impairments is unable to do so, is essential for adequate counseling. A more biographical approach of cognitive development is proposed to understand the differential life courses of children and adolescents with a history of epilepsy surgery. A perspective of “functioning” rather than cognitive “functions,” conceived of as independent entities, will help bridge the gap between neurocognitive and more biographical approaches to the functioning of children after epilepsy surgery.
Erythrodermie bei einem jungen Säugling als initiales klinisches Zeichen eines schweren Immundefekts (T-B-NK+ SCID)
Authors: Ascherl R. , Sorge I. , Schulz A. , Schuetz C. , Sack U. , Schwarz K. , Schuster V. 
Published: December 2018

ZusammenfassungEin junger Säugling, ehemaliges Zwillingsfrühgeborenes, wurde mit Erythrodermie vorgestellt. Nachdem eine symptomatische Therapie nicht erfolgreich war, ergab die erweiterte Diagnostik den Verdacht auf einen Immundefekt. Klinisch war das Kind sonst vollkommen unauffällig. Die immunologische Abklärung war wegweisend für einen schweren kombinierten Immundefekt. Der Patient wurde von der haploidentischen Mutter stammzelltransplantiert.
Aerogen übertragene Infektionskrankheiten bei Kindern auf Reisen
Authors: Rau C. , Lindert J. , Kotsias-Konopelska S. , Kobbe R. 
Published: December 2018

ZusammenfassungErkrankungen der Atemwege gehören zu den häufigsten Gesundheitsproblemen von Kindern und treten regelhaft auch während und nach Reisen auf. Virale Atemwegsinfektionen können die Reisefähigkeit von Kindern – und damit auch ihren Angehörigen – ungünstig beeinflussen, beispielsweise durch Fieber, bronchiale Obstruktion und Schwierigkeiten beim Druckausgleich während des Fliegens durch Schwellungen und Sekretionen der Schleimhäute und der eustachi‘schen Röhre. Zu den reisemedizinisch relevanten aerogen übertragenen Krankheiten zählen neben banalen, viralen Erkältungen auch potenziell schwer verlaufende Viruserkrankungen, allen voran die saisonale Influenza und die Masern, sowie bakterielle Infektionen durch Meningokokken und die Tuberkulose. Gegen einige dieser Erkrankungen stehen effektive Impfstoffe zur Verfügung. Auch seltene, schwer verlaufende Atemwegsinfektionen, die unter bestimmten epidemiologischen Umständen außerhalb Europas erworben werden können, sollen im Folgenden exemplarisch an den Erkrankungen Middle East respiratory syndrome (MERS) und der Histoplasmose dargestellt werden.
Flugreisen bei Kindern
Authors: Siedenburg J. 
Published: December 2018

ZusammenfassungDas physiologische Milieu in Passagierflugzeugen ist durch einen beim Start abnehmenden und bei der Landung wieder zunehmenden Luftdruck, milde Hypoxie, Lufttrockenheit gekennzeichnet. Hinzu kommt die Zeitverschiebung. Für Notfälle steht eine umfangreiche Notfallausrüstung zur Verfügung. Gesunde Kinder und auch die meisten Kinder mit Vorerkrankungen tolerieren die Veränderungen an Bord in der Regel problemlos, bei Bedarf ist eine umfangreiche medizinische Zusatzausrüstung verfügbar. Auch schwerer erkrankte Kinder können auf dem Luftweg transportiert werden. Bei der Beurteilung der Flugreisetauglichkeit sind die besonderen physiologischen Umstände ebenfalls zu beachten. Die Empfehlungen haben in der Regel eine empirische Basis. Randomisierte, kontrollierte Studien, Metaanalysen oder Register sind kaum verfügbar. Bei seltenen, komplexen oder kritischen Krankheitsbildern muss die Flugreisetauglichkeit jedoch im Einzelfall unter Beteiligung der behandelnden Ärzte, ggf. weiteren Fachärzten und des verantwortlichen Flugmediziners individuell eingeschätzt werden.
Almost solubility of classes of non-linear integral equations of the first kind on cones
Authors: Kokurin M. Yu. 
Published: December 2018

Abstract
Using convexity properties of the images of completely continuous non-linear integral operators, we describe the closed convex cones lying either in the recessive cone, or in the tangent cone of the closed image of the operator being studied (depending on the nature of the integrand). These cones are determined by the principal part of the asymptotics of the integrand at infinity, independently of the variation of the subordinate part. We discuss applications to the generalized solubility of non-linear integral equations of the first kind.
On the non-symplectic involutions of the Hilbert square of a K3 surface
Authors: Boissière S. , Cattaneo A. , Markushevich D. G. , Sarti A. 
Published: December 2018

Abstract
We investigate the interplay between the moduli spaces of ample

-polarized IHS manifolds of type

and of IHS manifolds of type

with a non-symplectic involution with invariant lattice of rank one. In particular, we describe geometrically some new involutions of the Hilbert square of a K3 surface whose existence was proven in a previous paper of Boissière, Cattaneo, Nieper-Wisskirchen, and Sarti.
Stringy

-functions of canonical toric Fano threefolds and their applications
Authors: Batyrev V. V. , Schaller K. 
Published: December 2018

Abstract
Let

be a

-dimensional lattice polytope containing exactly one interior lattice point. We give a simple combinatorial formula for computing the stringy

-function of the

-dimensional canonical toric Fano variety

associated with

. Using the stringy Libgober– Wood identity and our formula, we generalize the well-known combinatorial identity

which holds for

-dimensional reflexive polytopes

.
Adaptive energy-saving approximation for stationary processes
Authors: Kabluchko Z. A. , Lifshits M. A. 
Published: December 2018

Abstract
We consider a stationary process (with either discrete or continuous time) and find an adaptive approximating stationary process combining high quality approximation and other good properties that can be interpreted as additional smoothness or small expense of energy. The problem is solved in terms of spectral characteristics of the original process using the classical analytic methods of prediction theory.
Fifth order semi analytical solution of exact Korteweg-de Vries equation
Authors: Afriadi  , Zahara Yulia , Halfiani Vera , Mardi Harish Abdillah , Ramli Marwan 
Published: December 2018

Abstract
This study concerns on the solution of exact Korteweg de Vries (KdV) equation in its application in generating extreme waves. The method of asymptotic expansion is employed up to the fifth order. In the previous research, the same method was applied up to the third order and fifth order but it only considered the side band solutions. Here, solutions at each order will be analyzed. The existence of resonance terms at the odd orders and side band terms are interesting to observe considering the importance of these quantities in analyzing the wave deformation which link to the phenomenon of wave’s amplitude amplification. Bichromatic signal is used as the initial wave signal as it experiences instability during its propagation which results the amplitude amplification. The amplitude amplification is presented as Maximal Temporal Amplitude (MTA) which is a quantity measuring the highest elevation at every spatial position during the observation time.
Flow field analysis of Jiangou mine goaf
Authors: Li Chengyu , Zhang Lili 
Published: December 2018

Abstract
With the increase of mining depth, many coal mines have the co-occurrence of natural fire and gas disasters. According to the actual situation of alkali ditch coal mine, this paper established a mathematical model and geometric model of mined-out area by using COMSOL software to carry on the numerical simulation. Study of nitrogen injection and gas extraction of goaf flow field and the influence of oxidation temperature zone, provided the basis for mine fire and gas disaster prevention and control.