bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fe,N‐Codoped Graphdiyne Displaying Efficient Oxygen Reduction Reaction Activity
Authors: Si Wenyan , Yang Ze , Wang Xin , Lv Qing , Zhao Fuhua , Li Xiaodong , He Jianjiang , Long Yunze , Gao Juan , Huang Changshui 
Published: November 2018

AbstractOn account of the high‐cost of platinum, researchers are working to develop a new catalyst that is cheaper and has a catalytic effect equivalent to platinum. Herein, owing to the unique acetylenic bonds in graphdiyne, iron, nitrogen co‐doped graphdiyne (Fe‐N‐GDY) is a promising nonprecious metal catalyst, which has been developed with just a small amount of iron precursor with the plan to substitute it for Pt‐based catalysts. The as‐synthesized Fe‐N‐GDY composited catalyst shows excellent catalytic performance with the onset potential of 0.94 V versus reversible hydrogen electrode and limited current density of 5.4 mA cm−2. Moreover, it shows excellent resistance to methanol poisoning and stability in both acidic and alkaline electrolytes, which makes potentially applicable in the oxygen reduction reaction field.
Concurrent detection of lysosome and tissue transglutaminase activation in relation to cell cycle position during apoptosis induced by different anticancer drugs
Authors: Halicka H. Dorota , Li Jiangwei , Zhao Hong , Darzynkiewicz Zbigniew 
Published: November 2018

AbstractDescribed is the new cytometric approach do detect either stimulation or a collapse of lysosomal proton pump (lysosomes rupture) combined with activation of transglutaminase 2 (TG2) during induction of apoptosis. Apoptosis of human lymphoblastoid TK6 cells was induced by combination of 2‐deoxyglucose with the isoquinoline alkaloid berberine, by DNA topoisomerase I inhibitor camptothecin, its analog topotecan, topoisomerase II inhibitors etoposide or mitoxantrone, as well as by the cytotoxic anticancer ribonuclease ranpirnase (onconase). Activity of the proton pump of lysosomes was assessed by measuring entrapment and accumulation of the basic fluorochrome acridine orange (AO) resulting in its metachromatic red luminescence (F>640) within these organelles. Activation of TG2 was detected in the same cell subpopulation by the evidence of crosslinking of cytoplasmic proteins revealed by the increased intensity of the side light scatter (SSC) as well as following cell lysis by detergent, by its red fluorescence after staining by sulforhodamine 101. Because at low AO concentration nuclear DNA of the lysed cells was stoichiometrically stained green (F530) its quantity provided information on effects of the drug treatments on cell cycle in relation to activation of TG2. The data reveal that activation of lysosomal proton pump was evident in subpopulations of cells treated with 2‐deoxyglucose plus berberine, topotecan, etoposide and mitoxantrone but not with ranpirnase. The collapse of lysosomal proton pump possibly reporting rupture of these organelles was observed in definite cell subpopulations after treatment with each of the studied drugs. Because regardless of the inducer of apoptosis TG2 activation invariably was correlated with lysosomes rupture it is likely that it was triggered by calcium ions or protons released from the ruptured lysosomes. This new methodological approach offers the means to investigate mechanisms and factors affecting autophagic lysosomes proton pump activity vis‐à‐vis TG2 activation that are common in several pathological states. © 2019 International Society for Advancement of Cytometry
Drug sales confirm clinical advantage of multi‐target inhibition of drug escapes by anticancer kinase inhibitors
Authors: Chen Shangying , Yang Sheng Yong , Chen Zhe , Tan Ying , Jiang Yu Yang , Chen Yu Zong 
Published: November 2018

AbstractThe clinical advantage of co‐targeting cancer drug escape has been indicated by the percentage of these co‐targeting drugs among all multi‐target drugs in clinics and clinical trials. This clinical advantage needs to be further interrogated from such perspectives as the clinical impact of multi‐target inhibition of drug‐escape mediators. This impact may be reflected by drug sales data, that is, multi‐target inhibition of higher number of drug‐escape mediators favors the expanded coverage of drug‐resistant patients leading to higher sales. We investigated whether this expectation is followed by the 25 FDA‐approved anticancer kinase inhibitors, which were divided into 11 groups of comparable therapeutic mechanisms and approval years. We found 19 (76%) drugs to follow and 3 (12%) drugs not to follow this expectation. The remaining two (8%) and one (4%) drugs cannot be assessed due to insufficient data and incomparability. Therefore, drug sales strongly indicate the clinical advantage of multi‐target inhibition of cancer drug escapes.
Heterogeneous bonding between cyclo‐olefin polymer (COP) and glass‐like substrate by newly developed water vapor‐assisted plasma, Aqua Plasma Cleaner
Authors: Terai Hirokazu , Funahashi Risa , Hashimoto Taichi , Kakuta Masaya 
Published: November 2018

AbstractTo develop high‐performance and low‐cost microfluidic devices, heterogeneous bonding with cyclo‐olefin polymer (COP) and glass substrate was investigated by low‐pressure plasma using water vapor. COP and glass‐like substrate were bonded at room temperature under its own weight, and the bonding strength reached the breaking point of base material strength. Water contact angle of the COP and glass surface after water vapor plasma was less than 1° (superhydrophilic) and showed stable hydrophilicity even after 30 days. Water vapor plasma and COP surface were analyzed by optical emission spectroscopy (OES) and x‐ray photoelectron spectroscopy (XPS) to study the reaction of room temperature bonding.
Comparison of Insulin Determination on NiNPs/chitosan‐ MWCNTs and NiONPs/chitosan‐MWCNTs Modified Pencil Graphite Electrode
Authors: Šišoláková Ivana , Hovancová Jana , Oriňaková Renáta , Oriňak Andrej , Rueda Garcia Daniel , Shylenko Oleg , Radoňák Jozef 
Published: November 2018

AbstractThe rising amount of patients suffering for diabetes mellitus increases the requirements for effective insulin sensors. Carbon materials are a suitable choice for the development of insulin sensors due to their electrochemical characteristics. Pencil graphite electrodes (PGE) represent the trade‐off between price and excellent conductive properties. The modification of PGE by NiO and Ni nanoparticles fixed by chitosan results in surface area enlargement and improved electrocatalytic properties. This paper is focused on the comparison of different properties of Ni and NiO nanoparticles and their effect on redox reaction mechanism of insulin and detection characteristics. The electrode modified by Ni nanoparticles displays linear range of 1 μM–5 μM (R2 0.80), limit of detection (LOD) of 4.34 μM and sensitivity of 0.12 μA/μM. On the other hand, the electrode modified by NiO nanoparticles displays enhanced electrochemical characteristics such as linear range of 0.05 μM–5 μM (R2 0.99), limit of detection of 260 nM and sensitivity of 0.64 μA/μM. These properties make the NiO nanoparticles modified PGE the appropriate candidate for insulin determination.
Participatory Action Research as a Framework for Transdisciplinary Collaboration: A Pilot Study on Healthy, Sustainable, Low‐Income Housing in Delhi, India
Authors: Nix Emily , Paulose Jacob , Shrubsole Clive , Altamirano‐Medina Hector , Belesova Kristine , Davies Michael , Khosla Renu , Wilkinson Paul 
Published: November 2018

AbstractTo tackle global challenges, research collaborations need to integrate multiple disciplinary perspectives and connect with local practices to find solutions that are sustainable and impactful. This paper discusses how participatory action research (PAR) is used as a framework for transdisciplinary collaboration to integrate different disciplines and identify healthy and sustainable housing solutions appropriate for local development practices and policy. By analyzing a transdisciplinary research collaboration investigating housing interventions for low‐income settlements in Delhi, reflections and recommendations are provided for other projects wishing to use a similar methodology. It is found that the PAR framework has successfully guided the integration of contrasting methods and improved the impact of research outcomes, resulting in the emergence of new shared practices. However, it proves to be challenging and requires heightened communication and engagement to achieve understanding between all disciplines and practices. It is recommended that focus is given to developing relationships and effective communication channels and that time should be preallocated for reflection. The work provides insights for integrating academic disciplines, the community, and relevant stakeholders in the cocreation of evidence that is paramount to formulate effective solutions to global challenges.
Covalent Grafting Terbium Complex to Alginate Hydrogels and Their Application in Fe3+ and pH Sensing
Authors: Zhang Zeyu , Liu Fengyi , Xu Quanqing , Zhu Han , Zhu Aixin , Kou Junfeng 
Published: November 2018

AbstractBiocompatible luminescent hydrogels containing covalently linked terbium complexes with a macrocyclic ligand are prepared by a facile method. The environmentally friendly preparation procedure is carried out at room temperature using water as a solvent. These new hybrid materials can act as luminescent sensors to detect Fe3+ with relative selectivity and high sensitivity. The hydrogels also show pH sensing with a wide range.
Pattern of planned systemic therapy usage in newly diagnosed, nonmetastatic squamous cell carcinoma of the head and neck in a commercially insured population in the United States
Authors: Park Jong Chul , Gourin Christine G. , Kiess Ana P. , Mehra Ranee , Forastiere Arlene A. , Kang Hyunseok 
Published: November 2018

AbstractBackgroundWe analyzed systemic therapy plans submitted for commercially insured patients with untreated, newly diagnosed squamous cell carcinoma of the head and neck (SCCHN) to investigate patterns of practice.MethodsConsecutive chemotherapy treatment plans were submitted using Eviti Connect (https://www.marylandphysicianscare.com/content/dam/centene/maryland/pdfs/evitiConnectFactSheet.pdf) portal for preauthorization between June 1, 2011, and June 30, 2015, were analyzed.ResultsA total of 387 treatment plans were submitted for 340 patients; 68 and 272 patients were from academic centers and community practices, respectively. Single agent cisplatin (57%), cetuximab (18%), and carboplatin (9%) were the most commonly proposed regimens concurrent with definitive radiotherapy (RT). The frequency of cetuximab use was not significantly different between academic centers and community practices. A clinical trial was proposed in only 15% of patients.ConclusionAmong commercially insured patients with newly diagnosed, nonmetastatic SCCHN, the choice of systemic therapy in initial treatment plans was not significantly different between academic centers and community practices. Clinical trials are underutilized and should be encouraged.
Patterns of failure after postoperative intensity‐modulated radiotherapy for locally advanced buccal cancer: Initial masticator space involvement is the key factor of recurrence
Authors: Lin Yu‐Wei , Chen Ya‐Fang , Yang Ching‐Chieh , Ho Chung‐Han , Wu Tai‐Ching , Yen Ching‐Yu , Lin Li‐Ching , Lee Steve P. , Lee Ching‐Chih , Tai Ming‐Hong 
Published: November 2018

AbstractBackgroundThe purpose of this study was to determine failure patterns and clinicopathologic prognostic factors in patients with locally advanced buccal cancer after postoperative intensity‐modulated radiotherapy (IMRT).MethodsEighty‐two patients with locally advanced (American Joint Committee on Cancer [AJCC] stage III/IV) buccal cancer who underwent surgery followed by postoperative IMRT between January 2007 and October 2012 were retrospectively analyzed.ResultsEighteen patients had local recurrences as the first recurrent site and 11 had supramandibular notch recurrences; the majority of recurrences were classified as marginal failures. The median time from the first local or regional recurrence to death was 5.9 months. In multivariate analyses of survivals, the initial masticator space involvement was the most important prognostic factor. Masticator space involvement, N classification, and maxillectomy were the significant prognostic predictors for supramandibular notch recurrences.ConclusionPostoperative IMRT for buccal cancer should not include the surgical beds alone, rather, it should be based on the potential patterns of spread.
Spectral analysis of continuous redox data reveals geochemical dynamics near the stream–aquifer interface
Authors: Wallace Corey D. , Sawyer Audrey H. , Barnes Rebecca T. 
Published: November 2018

AbstractChanges in streamflow and water table elevation influence oxidation–reduction (redox) conditions near river–aquifer interfaces, with potentially important consequences for solute fluxes and biogeochemical reaction rates. Although continuous measurements of groundwater chemistry can be arduous, in situ sensors reveal chemistry dynamics across a wide range of timescales. We monitored redox potential in an aquifer adjacent to a tidal river and used spectral and wavelet analyses to link redox responses to hydrologic perturbations within the bed and banks. Storms perturb redox potential within both the bed and banks over timescales of days to weeks. Tides drive semidiurnal oscillations in redox potential within the streambed that are absent in the banks. Wavelet analysis shows that tidal redox oscillations in the bed are greatest during late summer (wavelet magnitude of 5.62 mV) when river stage fluctuations are on the order of 70 cm and microbial activity is relatively high. Tidal redox oscillations diminish during the winter (wavelet magnitude of 2.73 mV) when river stage fluctuations are smaller (on the order of 50 cm) and microbial activity is presumably low. Although traditional geochemical observations are often limited to summer baseflow conditions, in situ redox sensing provides continuous, high‐resolution chemical characterization of the subsurface, revealing transport and reaction processes across spatial and temporal scales in aquifers.
Aflatoxin biotransformation by commercial peroxidase and its application in contaminated food
Authors: Marimón Sibaja Karen Vanessa , de Oliveira Garcia Sabrina , Feltrin Ana Carla Penteado , Diaz Remedi Rafael , Cerqueira Maristela Barnes Rodrigues , Badiale‐Furlong Eliana , Garda‐Buffon Jaqueline 
Published: November 2018

AbstractBACKGROUNDAflatoxin B1 (AFB1) is the most commonly occurring and the most toxic of all aflatoxins (AFs). It is responsible for liver cancer in animals and it is listed as a Group I carcinogen by the International Agency for Research on Cancer. Thus, it is necessary to find decontamination methods that show efficiency, specificity, low cost, and that allow the disposal of contaminated raw materials into the environment. This study evaluated the effects of enzyme concentration, pH, temperature and reaction time on AFB1 biotransformation by commercial peroxidase (POD) in a model solution (100 mmol L−1 phosphate buffer).RESULTSWhen 0.015 U mL−1 was used to treat 0.5 µg L−1 of AFB1, at pH 7.0–8.0 and 30–40 °C, for 8.0 h, the AFB1 biotransformation reached its maximum (97%). KM value of POD for the biotransformation of AFB1 was 0.0160 µmol L−1 (5 µg L−1) with a VMAX of 6.4 µmol L−1 min−1, which were determined based on Lineweaver‐Burk's plot. POD (0.015 U mL−1) effectively reduces AFB1 (97%) and M1 (65%) in UHT milk and AFB1 (24%) in lager beer samples acquired in markets of Rio Grande‐RS (Brazil).CONCLUSIONThe use of POD may be a strategy to mitigate the impact of AFs found in food to reduce the risk of consumer exposure. © 2018 Society of Chemical Industry
Biomodification of compromised extraction sockets using hyaluronic acid and rhBMP‐2: An experimental study in dogs
Authors: Kim Jung‐Ju , Ben Amara Heithem , Park Jung‐chul , Kim Sungtae , Kim Tae‐Il , Seol Yang‐Jo , Lee Yong‐Moo , Ku Young , Rhyu In‐Chul , Koo Ki‐Tae 
Published: November 2018

AbstractBackgroundThis experimental study aims to evaluate the effect of hyaluronic acid on healing of infected extraction sockets compared with recombinant human bone morphogenetic protein‐2 (rhBMP‐2).MethodsBoth third and fourth mandibular premolars of six beagle dogs were hemisected, and the distal roots were extracted at baseline. Subsequently, combined endodontic‐periodontic lesions were induced at the remaining mesial roots. After 4 months, the mesial roots on both sides of the mandible were removed. Four sockets per dog were randomly allocated to four groups: Group 1, Control; Group 2, only absorbable collagen sponge (ACS: carrier); Group 3, 1% hyaluronic acid (HA) gel + ACS; and Group 4, rhBMP‐2 + ACS. After 3 months of healing, the dogs were euthanized for microcomputed tomography and histologic analysis.ResultsAfter the lesion induction period (4 months), communication between the periodontal lesion and endodontic periapical lesion was observed at all remaining mesial roots. Alveolar bone overgrowth was observed in groups 3 and 4, but bone volume density was not significantly different among all groups. At the crestal portion, mineralization, and osteocalcin expression were higher in groups 3 and 4 than in groups 1 and 2.ConclusionTreatment with HA can promote bone formation and improve the wound healing rate comparable to rhBMP‐2 in infected extraction sockets.
Simultaneous determination of selected estrogenic endocrine disrupting chemicals and bisphenol A residues in whole milk using fabric phase sorptive extraction coupled to HPLC‐UV detection and LC‐MS/MS
Authors: Mesa Rodolfo , Kabir Abuzar , Samanidou Victoria , Furton Kenneth G. 
Published: November 2018

AbstractA simple and sensitive analytical methodology is developed for rapid screening and quantification of selected estrogenic endocrine disrupting chemicals and bisphenol A from intact milk using fabric phase sorptive extraction in combination with high‐performance liquid chromatography coupled to ultraviolet detection/tandem mass spectrometry. The new approach eliminates protein precipitation and defatting step from the sample preparation workflow. In addition, the error prone and time‐consuming solvent evaporation and sample reconstitution step used as the sample post‐treatment has been eliminated. Parameters with most significant impact on the extraction efficiency of fabric phase sorptive extraction including sorbent chemistry, sample volume, extraction time have been thoroughly studied and optimized. Separation of the selected estrogenic endocrine disrupting chemicals including α‐estradiol, hexestrol, estrone, 17α‐ethinyl estradiol, diethylstilboestrol, and bisphenol A were achieved using a Zorbax Extend‐C18 high‐performance liquid chromatography column (15 cm × 4.6 mm, 5 μm particle size). The limit of detection values obtained in fabric phase sorptive extraction with high‐performance liquid chromatography with ultraviolet detection ranged from 25.0 to 50.0 ng/mL. The method repeatability values were 3.6–13.9 (relative standard deviation, %) and intermediate precision values were 4.6–12.7 (relative standard deviation, %). The fabric phase sorptive extraction method was also coupled to liquid chromatography with tandem mass spectrometry for identifying each endocrine disrupting chemical at 10 ng/mL.
What's happening with open annotation? Discoverability, engagement, community
Authors: Staines Heather 
Published: November 2018

Key points

Standards‐based annotation can be used anywhere on the web across HTML, PDF, EPUB, and data to make public, private, and group notes on top of the version of record.
Publishers can host a branded and moderated annotation layer and determine whether they want it open to anyone or restricted to specific users.
Annotations have unique persistent web addresses that make it possible to link to a paragraph, sentence, or word rather than a page‐level URL.
Interoperable annotation will allow annotators using different annotation clients to interact with annotations made by others.
Open annotation is already being used in peer review, in workflows, to indicate changes and updates, and to add context to content.
The prescribed Ricci curvature problem on three‐dimensional unimodular Lie groups
Authors: Buttsworth Timothy 
Published: November 2018

AbstractLet G be a three‐dimensional unimodular Lie group, and let T be a left‐invariant symmetric (0,2)‐tensor field on G. We provide the necessary and sufficient conditions on T for the existence of a pair consisting of a left‐invariant Riemannian metric g and a positive constant c such that , where is the Ricci curvature of g. We also discuss the uniqueness of such pairs and show that, in most cases, there exists at most one positive constant c such that is solvable for some left‐invariant Riemannian metric g.
Sensing α‐Synuclein From the Outside via the Prion Protein: Implications for Neurodegeneration
Authors: Brás Inês Caldeira , Lopes Luísa V. , Outeiro Tiago Fleming 
Published: November 2018

AbstractParkinson's disease and other synucleinopathies are characterized by the accumulation of aggregated α‐synuclein in intracellular proteinaceous inclusions. The progressive nature of synucleinopathies seems to be related to the cell‐to‐cell spreading of α‐synuclein pathology, and several possible mechanisms have been put forward to explain this phenomenon. In our recent study, we found that α‐synuclein oligomers interact with cellular prion protein in glutamatergic synapses. This interaction triggered a signaling cascade involving phosphorylation of Fyn kinase and activation of the N‐methyl‐d‐aspartate receptor, thereby leading to synaptic dysfunction. Here, we present relevant plasma membrane proteins that have been described to interact with α‐synuclein and discuss the possible pathological implications. We focus primarily on the prion protein and propose a pathological mechanism in which the interaction between α‐synuclein and prion protein leads to the formation of cofilin/actin rods, culminating in long‐term potentiation impairment and cognitive dysfunction. We posit that deciphering the mechanisms involved in sensing specific forms of extracellular α‐synuclein and transducing this information may prove invaluable in our quest to devise novel diagnostic and therapeutic approaches in PD and other synucleinopathies. © 2018 International Parkinson and Movement Disorder Society
Ratios of proteins in cerebrospinal fluid in Parkinson's disease cognitive decline: prospective study
Authors: Delgado‐Alvarado Manuel , Dacosta‐Aguayo Rosalía , Navalpotro‐Gómez Irene , Gago Belén , Gorostidi Ana , Jiménez‐Urbieta Haritz , Quiroga‐Varela Ana , Ruiz‐Martínez Javier , Bergareche Alberto , Rodríguez‐Oroz María C. 
Published: November 2018

ABSTRACT
Background: There is a need for biomarkers of dementia in PD.
Objectives: To determine if the levels of the main CSF proteins and their ratios are associated with deterioration in cognition and progression to dementia in the short to mid term.
Methods: The Parkinson's Progression Markers Initiative database was used as an exploratory cohort, and a center‐based cohort was used as a replication cohort. Amyloid ß1‐42, total tau, threonine‐181 phosphorylated tau, and α‐synuclein in the CSF and the ratios of these proteins were assessed.
Results: In the Parkinson's Progression Markers Initiative cohort (n = 281), the total tau/amyloid ß1‐42, total tau/α‐synuclein, total tau/amyloid ß1‐42+α‐synuclein, and amyloid ß1‐42/total tau ratios were associated with a risk of progression to dementia over a 3‐year follow‐up. In the replication cohort (n = 40), the total tau/α‐synuclein and total tau/amyloid ß1‐42+α‐synuclein ratios were associated with progression to dementia over a 41‐month follow‐up.
Conclusion: Ratios of the main proteins found in PD patient brain inclusions that can be measured in the CSF appear to have value as short‐ to mid‐term predictors of dementia. © 2018 International Parkinson and Movement Disorder Society