bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fluorescence sentinel lymph node mapping in patients with cervical cancer
Authors: Mkrtchyan G. B. , Berlev I. V. , Trifanov Yu. N. , Kozlova E. N. , Ibragimov Z. N. , Urmancheeva A. F. , Mikaya N. A. , Ulrikh E. A. 
Published: February 2019

Objective:to assess the efficacy of fluorescence sentinel lymph node (SLN) detection with indocyanine green (ICG) in patients with cervical cancer.Materials and methods.We analyzed the results of examination and treatment in 80 patients with morphologically verified stage IA1–IIA1 cervical cancer. All patients underwent laparoscopic surgery with fluorescence SLN detection with ICG using a high-resolution infrared camera.Results.SLNs were detected in 78 out of 80 patients (97.5 %); the rate of bilateral SLN detection was 80.0 % (64 out of 80). SLNs were not identified in 2 patients only (2.5 %). The majority of SLNs (99 out of 176; 56.28 %) were located in the internal group of lymph nodes, near to the common iliac artery bifurcation. Eleven out of 80 patients (13.75 %) were found to have pelvic lymph node metastasis. SLN metastatic lesions were observed in 10 out of 80 patients (12.5 %), whereas only one participant had non-SLN metastasis. Therefore, the sensitivity of the fluorescence method with ICG was 98.75 %.Conclusion.Fluorescence SLN mapping with ICG in patients with stage IA1–IIA1 cervical cancer is an effective diagnostic method allowing SLN topical diagnosis, intraoperative restaging, and correction of the treatment strategy.
Sanatsal Bir Etkinlik Olarak Fotoğraf Yarışmasının Kültürel Değerlerin Paylaşımına Yansıması: Anadolu Üniversitesi Açıköğretim Fakültesi Öğrencilerinin Görüşleri
Authors: ÜNALAN Halit Turgay 
Published: February 2019

Uzaktan eğitim ile sanat, bilişim teknolojilerini ve
tasarım disiplinlerini etkin olarak kullanmaktadır. Bu iki disiplinin
ilişkilendirilmesi ile hedef kitlesi geniş ve yaygın etkisi olan projeler
üretilebilecek bu da uzaktan eğitime ve sanat alanına yeni boyutlar
getirecektir. Açık ve Uzaktan Eğitim ve Güzel Sanatlar eğitimi gibi evrensel
boyutta etkileşim ve iletişimini sağlayan iki disiplinin kesişim noktası olarak
bu çalışmanın bu tür bir araştırmaya duyulan gereksinimi gidereceği
düşünülmektedir. Araştırmanın amacı; bu proje ile gerçekleştirilen sanatsal
etkinlikler ile Anadolu Üniversitesi’ne ilişkin öğrencilerin görüşlerini
belirlemektir. Bu amaç doğrultusunda bilimsel veriler araştırmanın amaçlarını
doğrudan destekleyecek şekilde hem Anadolu Üniversitesi’ne ilişkin hem de
sanatsal ve kültürel etkinliklere yönelik öğrenci görüşleri alınarak
toplanmıştır. Araştırmada veri toplama aracı olarak açık uçlu anket ve yarışma
sonunda başarı ödülü alan ve eserleri sergilenmeye değer bulunan 3 öğrenci ile
yarı yapılandırılmış görüşme kullanılmıştır. Anket verileri betimsel analiz
yoluyla çözümlenmiş, görüşme verileri destek veri olarak kullanılmıştır.
Araştırmaya katılan uzaktan eğitim öğrencilerinin tamamı açık ve uzaktan
eğitimin sanatsal etkinliklerle ilişkilendirilmesini çok yararlı bulduklarını
belirterek olumlu görüş bildirmişlerdir. Bu bağlamda bulgulara dayalı olarak;
Açıköğretim sistemi ile öğrenim gören öğrencilere yönelik öğrencilerin aktif
katılımını gerektiren sanatsal ve kültürel etkinliklerin arttırılması
önerilebilir.&nbsp;
HIGH-FREQUENCY ELECTROCORTICOGRAPHIC MARKER OF EPILEPTOGENIC ZONE
Authors: Arkhipova N. B. , Ulitin A. Yu. , Tastanbekov M. M. , Aleksandrov M. V. 
Published: February 2019

Background. The search for new markers of the epileptogenic zone (EZ) for the surgical treatment of epilepsy is currently of relevance. Pathological high-frequency oscillations (pHFO) are considered to be a potential marker for EZ. Papers devoted to this topic are few and insufficiently systematized, mostly due to a small quantity of patients.Objective. This study was aimed to determine the diagnostic efficacy of high-frequency electrocorticography (HF ECoG) based on the epilepsy surgery outcomes.Design and methods. This is an original retrospective study of high-frequency bioelectrical activity parameters in 114 patients who underwent surgical treatment in the Polenov Neurosurgical Institute Clinic during 2017–2018. In the subgroup of patients with pharmacoresistant course of structural epilepsy (21 patients) on the preresective electrocorticogram, the pHFO index was higher than in the subgroup with intracerebral neoplasms (11 patients), which may be associated with a longer history and severity of the disease.Results. Through the analysis of the high-frequency component of the post-resective HF ECoG, it was shown that the presence or absence of pHFO in the range of 250–500 Hz does not affect the seizure outcome. The dynamics of the high-frequency activity index before and after the resection are statistically significant for the seizure outcome prediction for structural epilepsy surgery. In this study, the specificity of the pHFO dynamics analysis technique was 85.71 % and sensitivity equaled 58.33 %.Conclusion. Thus, the HF ECoG and the assessment of the dynamics of the pHFO index in the range of 250–500 Hz can complement the traditional method of intraoperative ECoG in the range of up to 70 Hz, including the prediction of the results of surgical treatment.
DECREASE IN ACTIVITY OF THE INFLAMMATORY PROCESS AFTER IMPLANTATION OF SILICONE WITH ADSORBED MULTIPOTENT STROMAL CELLS
Authors: Maiborodin I. V. , Mikheeva T. V. , Kuzkin S. A. , Kadyrova A. I. , Maiborodina V. I. , Shevela A. I. 
Published: February 2019

Background. The wide spread of cellular technologies will sooner or later lead inevitably to the introduction of MMSC or their exosomes to patients who have implanted artificial materials in their organism. The engraftment of foreign bodies is accompanied first by acute and then chronic inflammation, very often acquiring a granulomatous character. A decrease in the activity of the inflammatory response can theoretically improve the results of implantation.Objective. To study the results of the influence of autologous MMSC of bone marrow origin (AMMSCBMO) adsorbed on silicone, on the inflammatory process that accompanies the implantation of this polymer in theexperiment. Design and methods. In different times, the condition of tissues around the implanted silicone with adsorbed AMMSCBMO was studied by method of light microscopy.Results. After the implantation of silicone with adsorbed AMMSCBMO, as compared with the results of the introduction of this material without use of cellular technologies, a smaller volume of loose fibrous connective tissue is formed around the encapsulated polymer. In this connective tissue after AMMSCBMO use the absolute number of all cells is lower in 2 weeks, and the percentage and numerical density of neutrophils — within 1–2 weeks. On the contrary, the relative number of erythrocytes within 1–2 weeks and macrophages at 1–3 weeks under the conditions of AMMSCBMO use were greater.Conclusion. A smaller volume of loose fibrous connective tissue and a decrease in the severity of cellular infiltration, in particular, the number of neutrophils, around the implanted silicone with AMMSCBMO indicates a decrease in the activity of the inflammatory reaction as a result of the use of cellular technologies, more rapid cleansing of postoperative wound from debris, the success of reparative processes and the creation of conditions for the integration of a foreign bodies into the organism.
THE ROLE OF MDCT ANGOIGRAPHY IN THE DIAGNOSIS OF TAKAYASU ARTERITIS. CASE REPORT
Authors: Basek I. V. , Berezkina N. N. 
Published: February 2019

Takayasu’s disease (non-specific aorto-arteritis) is a chronic, idiopathic, inflammatory disease that primarily affects large vessels, such as the aorta and its major branches, including the pulmonary and coronary arteries. It often develops in women under the age of 50 years. Accurate and early diagnosis plays an important role in the prognosis of life in patients with this pathology. Complaints of patients with lesions of the aorta and its branches are non-specific in nature and are characterized by fever, night sweats, malaise and arthralgia, passing under the “mask” of other diseases. With the progression of the disease, stenoses or aneurysms occur in the arteries, which leads to ischemia of the limbs and internal organs, manifested by the corresponding clinical manifestations.The article presents the observation of aorto-arteritis Takayasu type V (generalized variant) in the woman of 26 years.
Approximating Permeability of Microcomputed-Tomography Images Using Elliptic Flow Equations
Authors: Chung T.. , Wang Y. D. , Armstrong R. T. , Mostaghimi P.. 
Published: February 2019

Summary
Direct simulation of flow on microcomputed-tomography (micro-CT) images of rocks is widely used for the calculation of permeability. However, direct numerical methods are computationally demanding. A rapid and robust method is proposed to solve the elliptic flow equation. Segmented micro-CT images are used for the calculation of local conductivity in each voxel. The elliptic flow equation is then solved on the images using the finite-volume method. The numerical method is optimized in terms of memory usage using sparse matrix modules to eliminate memory overhead associated with both the inherent sparsity of the finite-volume two-point flux-approximation (TPFA) method, and the presence of zero conductivity for impermeable grain cells. The estimated permeabilities for a number of sandstone and carbonate micro-CT images are compared against estimation of other solvers, and results show a difference of approximately 11%. However, the computational time is 80% lower. Local conductivity can furthermore be assigned directly into matrix voxels without a loss in generality, hence allowing the pore-scale finite-volume solver (PFVS) to be able to solve for flow in a permeable matrix as well as open pore space. This has been developed to include the effect of microporosity in flow simulation.
Different managements of vertical gas breakthrough in femtosecond laser assisted LASIK
Authors: Wei Chenghua , Zhang Pengfei , Ge Yao , Mei Lixin , Song E 
Published: February 2019

Abstract
Background

To describe the different management of vertical gas breakthrough during FSL-LASIK.

Cases presentation

We present three cases that experienced a vertical gas breakthrough (VGB) during the flap creation for femtosecond laser assisted laser in situ keratomileusis (FSL-LASIK). All the cases were remedied using a femtosecond laser without the occurrence of adverse events during the second flap creation.

Conclusions

FSL-LASIK could be performed as a remedy for VGB in patients without obvious corneal lesions.
Load monitoring on Pilates training: a study protocol for a randomized clinical trial
Authors: Cavina Allysiê P. S. , Junior Eduardo Pizzo , Machado Aryane Flauzino , Biral Taise Mendes , Pastre Carlos Marcelo , Vanderlei Franciele Marques 
Published: February 2019

Abstract
Background: Currently there are campaigns to raise the awareness of the need to practice some physical exercise with several objectives, mainly as a preventive character. From this perspective, we can see the use of the Pilates method as an instrument of therapeutic exercise for the protection and promotion of health. However, despite being popularly performed, there is still no scientific evidence on the standardization of the use of the method and its progression to an adequate prescription of physical training. Therefore, the purpose of the study was to develop a protocol to monitor the progression of Pilates loads daily between the basic, intermediate and advanced levels, as well as to analyze the effect of the method on the psychometric, cardiorespiratory and autonomic parameters. Methods: there will be a total of 36 sessions of Pilates mat for 32 healthy men. In each training session, initially, cardiorespiratory parameters, pain through the Visual Analogue Scale (VAS), and a psychometric questionnaire will be collected for the volunteers. Heart rate (HR), subjective perception of effort (SPE), and RR intervals will be measured during the sessions for subsequent use to analyze the progression of the loads by monitoring the internal training load and heart rate variability (HRV), respectively. At the end of the sessions, cardiorespiratory parameters, the VAS, the psychometric questionnaire will be measured again and the participants will only be released after 15 minutes of rest for the final HR analysis and to re-respond to the PSE scale. Before and after the 36 sessions of training, participants will also be evaluated in relation to psychometric, cardiorespiratory, and autonomic parameters. Discussion: this study deserves to be highlighted as it is a parallel randomized clinical trial with standardization of training, with the purpose of monitoring the prescription of loads of the method, as well as verifying its efficacy in clinical, cardiorespiratory, and autonomic outcomes. The easy reproducibility of the protocol from its description, also improves the study, besides providing support for prescribing the method to the professionals involved.
A Comparison Between Scalp Nerve Block and Local Anesthetic Infiltration on the Inflammatory Response, Hemodynamic Response, and Postoperative Pain in Patients undergoing Craniotomy for Cerebral Aneurysms: A Randomized Controlled Trial
Authors: Yang Xi , Ma Jing , Chen Lei , Dong Rui , Li Ke , Lu Yayuan , Zhang MD Zongze , Peng MD Mian 
Published: February 2019

Abstract
BACKGROUND

The purpose of this study was to compare the effects of the scalp nerve block (SNB) and local anesthetic infiltration (LA) with ropivacaine 0.75% on postoperative inflammatory response, intraoperative hemodynamic response, and postoperative pain control in patients undergoing craniotomy.
The Role of Toll-Like Receptor 4 Mediates Microglial Activation during Remifentanil-Induced Hyperalgesia in Rats
Authors: chen xiangxiang , Wei Xin 
Published: February 2019

Abstract
Background: Opioids can induce a state of nociceptive sensitization, also known as opioid-induced hyperalgesia. Nevertheless, the exact mechanism is still unclear. The following study investigates the role of Toll-like receptor 4 (TLR4) in the microglia activation during remifentanil—induced hyperalgesia in rats’ model of incisional pain.
Methods: Mechanical allodynia induced by remifentanil was established in adult male Sprague–Dawley rats with incisional pain. Paw withdrawal threshold (PWT) and paw withdrawal thermal latency (PWTL) were performed to evaluate mechanical and thermal hyperalgesia. The 32-G catheter intrathecal placement was used to deliver a specific TLR4 antagonist (LPS-RS).Western blot analysis was performed to measure the expression of the TLR4 and Iba-1, while Immunoﬂuorescence staining was used to investigate the cell type and cell activation.
Results：Incisionalpain-remifentanil decreased the PWT and PWTL, upregulated the expression of TLR4 and microglia activation in the spinal cord. On the contrary, the intrathecal delivery of LPS-RS at the dose of 25 μg significantly decreased mechanical allodynia and prevented the upregulation of TLR4 induced by incisional pain-remifentanil
Conclusion: These findings suggest that TLR4 signaling pathway has an important role in incisional pain-remifentanil hyperalgesia, and that it could serve as the therapeutic target for persistent postsurgical pain
Acetate Kinase (AcK) is Essential for Microbial Growth and Betel-derived Compounds Potentially Target AcK, PhoP and MDR Proteins in M. tuberculosis, V. cholerae and Pathogenic E. coli: An in silico and in vitro Study
Authors: Tiwari Sandeep , Barh Debmalya , Imchen M. , Rao Eswar , Kumavath Ranjith K. , Seenivasan S. Prabu , Jaiswal Arun K. , Jamal Syed B. , Kumar Vanaja , Ghosh Preetam , Azevedo Vasco 
Published: February 2019

Background:
Mycobacterium tuberculosis, Vibrio cholerae, and pathogenic Escherichia coli
are global concerns for public health. The emergence of multi-drug resistant (MDR) strains of these
pathogens is creating additional challenges in controlling infections caused by these deadly bacteria. Recently,
we reported that Acetate kinase (AcK) could be a broad-spectrum novel target in several bacteria
including these pathogens.

Methods:
Here, using in silico and in vitro approaches we show that (i) AcK is an essential protein in
pathogenic bacteria; (ii) natural compounds Chlorogenic acid and Pinoresinol from Piper betel and
Piperidine derivative compound 6-oxopiperidine-3-carboxylic acid inhibit the growth of pathogenic E.
coli and M. tuberculosis by targeting AcK with equal or higher efficacy than the currently used antibiotics;
(iii) molecular modeling and docking studies show interactions between inhibitors and AcK that
correlate with the experimental results; (iv) these compounds are highly effective even on MDR strains
of these pathogens; (v) further, the compounds may also target bacterial two-component system proteins
that help bacteria in expressing the genes related to drug resistance and virulence; and (vi) finally, all the
tested compounds are predicted to have drug-like properties.

Results and Conclusion:
Suggesting that, these Piper betel derived compounds may be further tested
for developing a novel class of broad-spectrum drugs against various common and MDR pathogens.
Neurokinin-1 Receptor Antagonists as Anticancer Drugs
Authors: Muñoz Miguel , Coveñas Rafael 
Published: February 2019

Background::Human tumor cells lines and tumor samples overexpress the neurokinin-1 receptor (NK-1R). Substance P (SP), after binding to NK-1Rs, induces tumor cell proliferation, an antiapoptotic effect and promotes angiogenesis and the migration of cancer cells for invasion and metastasis.Methods: :In contrast, NK-1R antagonists block the previous pathophysiological actions mediated by SP. These antagonists promote the death of tumor cells by apoptosis. Peptide and non-peptide NK-1R antagonists have been reported.Results: :Peptide NK-1R antagonists show chemical modifications of the SP molecule (L-amino acids being replaced by D-amino acids), whereas non-peptide NK-1R antagonists include numerous compounds with different chemical compositions while showing similar stereochemical features (affinity for the NK- 1R). Currently, there are more than 300 NK-1R antagonists.Conclusion::In combination therapy with classic cytostatics, NK-1R antagonists have additive or synergic effects and minimize the side-effects of cytostatics. The effect of NK-1R antagonists as broad-spectrum anticancer drugs is reviewed and the use of these antagonists for the treatment of cancer is suggested.
Biology-oriented Drug Synthesis (BIODS), Structural Characterization and Bioactivities of Novel Albendazole Derivatives
Authors: Khan Momin , Khan Shahid , Salar Uzma , Khan Khalid Mohammed , Rehman Gauhar , Gul Naeem , Khan Iltaf 
Published: February 2019

Background:Albendazole is a drug, belongs to the family of benzimidazole, and used as an anthelmintic agent in both human and veterinary medicine. It is marketed as Albenza which is used for the treatment of a variety of parasitic worm infestations such as roundworms, tapeworms, and flukes. In recent past, we have reported various classes of compounds as anti-glycating agents, in continuation of Biology-oriented Drug Synthesis (BIODS), seventeen albendazole derivatives 2-18 were synthesized evaluated for yeast glucose uptake activity.Methods:In the present study, Albendazole (2 g, 7.5 mmol), potassium hydroxide (3 g) were dissolved in ethanol (50 mL) into a 250 mL round-bottomed flask and refluxed for 48 h. TLC (ethyl acetate: hexane, 6:4) was monitored in order to check the reaction progress. After completion, the reaction mixture was dried under air and washed with an excess of distilled water. Precipitates were dried and crystallized from ethanol. The product was characterized by EI-MS and 1H-NMR.Results:Our present study showed that all compounds showed a varying degree of yeast glucose uptake activity ranging between IC50 = 51.41-258.40 µM, compared with standard metronidazole (IC50 = 41.86 ± 0.09 µM). This study has identified a series of potential leads for anti-glycating agents.Conclusion:Biology-oriented drug synthesis and in vitro yeast glucose uptake activity of albendazole derivatives gave rise to a number of lead molecule such as 3 (IC50 = 59.37 ± 0.26 µM), 5 (IC50 = 59.70 ± 0.32 µM), 6 (IC50 = 60.78 ± 0.54 µM), 8 (IC50 = 54.61 ± 0.20 µM), 16 (IC50 = 56.57 ± 0.04 µM) and 14 (IC50 = 51.41 ± 1.25 µM).
Novel 3-{4-[2-Amino-4-(Substitutedphenyl)-2H-[1, 3] Oxazin/Thiazin-6-Yl} -2-Phenyl-3H-Quinazolin-4-One Derivatives as Enhancer of GABA Mediated Inhibition: Synthesis, Molecular Modeling and Pharmacological Studies
Authors: Jain Nimisha , Singour Pradeep Kumar 
Published: February 2019

Background:According to WHO, the 50 million people worldwide are suffering from epilepsy, making it one of the most common neurological diseases globally. Epilepsy is often characterized by neurobiological, cognitive, psychological and behavioral changes and that may enhance the susceptibility to seizures and affect the quality of life.Objective:The aim of the present work was to develop 2, 3 disubstituted 4-(3H)-quinazolinone derivatives in order to find an effective and highly lipophilic compound with lesser side effects and to evaluate them for anticonvulsant and neurotoxic activity.Methods:A novel series of 3-4-[2-amino-4-(substitutedphenyl)-2H-[1.3] oxazin/thiazin-6-yl 2- phenyl-3H-quinazolin-4-one derivatives were synthesized and evaluated for their anticonvulsant activity. The structures of the compound have been confirmed by spectral analysis. The molecular docking study was performed for finding the binding affinity with GABAA receptor in order to rationalize their anticonvulsant activities in a qualitative way. Quantitative estimate of drug-likeness was also performed which calculate the molecular properties and screen the molecules based on drug-likeness rules. Anticonvulsant activities of synthesized compounds were done by using (Maximal electroshock) MES induced seizures and subcutaneous pentylenetetrazole (scPTZ) induced seizure models in Wistar rats of either sex. None of the compounds demonstrated any sign of neurotoxicity.Results:Compounds 3-4-[2-amino-4-(fluorophenyl)-2H- [1, 3] oxazin-6-yl 2-phenyl-3H quinazolin-4-one (5i) and 3-4-[2-amino-4-(fluorophenyl)-2H- [1, 3] thiazin -6-yl 2-phenyl-3H quinazolin-4-one (5n) have shown significant activity against tonic seizure by the MES model and clonic seizure by scPTZ induced seizure model.Conclusion:These ten novels synthesized compounds had significant anticonvulsant activity. As a result, the compound (5i) and (5n) emerged out as the pilot molecule with a better anticonvulsant activity without any neurotoxicity, while the other compounds have moderate activity. QED analysis of compounds (5i) and (5n) also indicated that these compounds will have good oral absorption. The proposed work is to make efforts towards the development and identification of novel molecules as anticonvulsant agents by the synthesis of some novel quinazolinone derivatives with improved biological activity.