bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dendrimer‐encapsulated Cu(Π) nanoparticles immobilized on superparamagnetic Fe3O4@SiO2 nanoparticles as a novel recyclable catalyst for N‐arylation of nitrogen heterocycles and green synthesis of 5‐substituted 1H‐tetrazoles
Authors: Esmaeilpour Mohsen , Sardarian Ali Reza , Firouzabadi Habib 
Published: March 2018

In this study, dendrimer‐encapsulated Cu(Π) nanoparticles immobilized on superparamagnetic Fe3O4@SiO2 nanoparticles were prepared via a multistep‐synthesis. Then, the synthesized composite was fully characterized by various techniques such as fourier transform infrared (FT‐IR) spectroscopy, X‐ray diffraction (XRD), dynamic light scattering (DLS), UV‐vis spectroscopy, energy dispersive X‐ray analysis (EDX), thermogravimetric analysis (TGA) and vibration sample magnetometer (VSM). From the information gained byFE‐SEM and TEM studies it can be inferred that the particles are mostly spherical in shape and have an average size of 50 nm. Also, the amount of Cu is determined to be 0.51 mmol/g in the catalyst by inductively coupled plasma (ICP) analyzer. This magnetic nano‐compound has been successfully applied as a highly efficient, magnetically recoverable and stable catalyst for N‐arylation of nitrogen heterocycles with aryl halides (I, Br) and arylboronic acids without using external ligands or additives. The catalyst was also employed in a one‐pot, three‐component reaction for the efficient and green synthesis of 5‐substituted 1H‐tetrazoles using various aldehydes, hydroxylamine hydrochloride and sodium azide in water. The magnetic catalyst can be easily separated by an external magnet bar and is recycled seven times without significant loss of its activity.
Effect of octa(epoxycyclohexyl) POSS on thermal, rheology property, and foaming behavior of PLA composites
Authors: Wei Liu , Shicheng He , Hongfu Zhou 
Published: March 2018

ABSTRACTFoams of poly(lactic acid) (PLA)/octa(epoxycyclohexyl) polyhedral oligomeric silsesquioxanes (ePOSS) composite were prepared by melt‐mixing and solid‐state foaming methods. A systematic and accurate method was applied to evaluate the effects of epoxy‐based POSS on the structure of dispersion, thermal behavior, and rheological properties of PLA composites. The application of secondary electron–electron back‐scattered diffraction technique was used to observe the cellular micromorphology and micro‐phase dispersion in composite foams, simultaneously. The results indicated that secondary dispersion of POSS aggregates occurred in foaming process. The enhanced melt elasticity, dispersity of POSS, and crystallization morphology of PLA/POSS composite had a significant effect on the controlling foaming behavior. Thus, a homogeneous and finer cellular morphology of PLA/POSS composite foam with high expansion ratio was obtained with a proper content of POSS in the composites. © 2018 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2018, 135, 46399.
Sulfinate‐Salt‐Mediated Radical Relay Cyclization of Cyclic Ethers with 2‐Alkynylbenzonitriles toward 3‐Alkylated 1‐Indenones
Authors: Zhu Xiao‐Tong , Zhang Tian‐Shu , Zhao Qi , Cai Pei‐Jun , Hao Wen‐Juan , Tu Shu‐Jiang , Jiang Bo 
Published: March 2018

AbstractA new sulfinate salt‐mediated radical relay for the completion of C(sp3)−H bond indenylation of cyclic ethers with readily available 2‐alkynylbenzonitriles by combining silver/tert‐butyl peroxide (TBHP) was established, providing a wide range of 3‐alkylated 1‐indenones with generally good yields. Interestingly, the current reaction system can tolerate an S‐centered radical and a C‐centered radical in one pot, in which the S‐centered radical promotes the formation of the C‐centered radical to induce a radical cascade without disturbing the reaction process. A reaction mechanism is also proposed based on control experiments.
Consumer acceptance of innovations in food: A survey among Polish consumers
Authors: Sajdakowska Marta , Jankowski Paweł , Gutkowska Krystyna , Guzek Dominika , Żakowska‐Biemans Sylwia , Ozimek Irena 
Published: March 2018

AbstractThe aim of the study was to examine the possible factors that might contribute to consumer acceptance of food innovations. Particular attention was paid to 3 main factors: (a) relationship between socio‐demographic determinants and level of consumer innovation, (b) evaluation of consumer innovation acceptance, particularly toward animal‐derived food products, and (c) consumer preferences for health‐promoting food innovation over time. Studies were conducted using quantitative research methods in 2004 and 2011. An organic method of production, least important in 2004, was top rated in 2011, and ease of preparation dropped to the bottom of the list in 2011, whereas food origin, low fat, and sugar content were ranked in the first group of the considered factors in 2011. Since 2004, consumers have become used to products with various innovations. The new generation of Poles is relatively more open to new food products, due to the wide range of food products available on the free market. Furthermore, the group of well‐educated consumers with a higher level of income has increased in size, and this includes people interested in knowledge of a product's nutritional value and its health impact. Our study extends existing research in the area of understanding consumer expectations toward food innovations. The results not only contribute to the field of consumer behavior but also have practical potential for food market applications, especially for companies operating on or planning to enter the Polish food market, and which could be used for developing communication strategies.
Pseudomonas aeruginosa infection alters the macrophage phenotype switching process during wound healing in diabetic mice
Authors: Chen Sinuo , Li Renren , Cheng Chun , Xu Jing‐Ying , Jin Caixia , Gao Furong , Wang Juan , Zhang Jieping , Zhang Jingfa , Wang Hong , Lu Lixia , Xu Guo‐Tong , Tian Haibin 
Published: March 2018

ABSTRACTMacrophages play critical roles in wound healing process. They switch from “classically activated” (M1) phenotype in the early inflammatory phase to “alternatively activated” (M2) phenotype in the later healing phase. However, the dynamic process of macrophage phenotype switching in diabetic wounds burdened with bacteria is unclear. In this report, Pseudomonas aeruginosa, frequently detected in diabetic foot ulcers, was inoculated into cutaneous wounds of db/db diabetic mice to mimic bacterium‐infected diabetic wound healing. We observed that P. aeruginosa infection impaired diabetic wound healing and quickly promoted the expression of pro‐inflammatory genes (M1 macrophage markers) tumor necrosis factor‐α (tnf‐α), interleukin‐1β (il‐1β) and il‐6 in wounds. The expression of markers of M2 macrophages, including il‐10, arginase‐1, and ym1 were also upregulated. In addition, similar gene expression patterns were observed in macrophages isolated directly from wounds. Immunostaining showed that P. aeruginosa infection increased both the ratios of M1 and M2 macrophages in wounds compared with that in control groups, which was further confirmed by in vitro culturing macrophages with P. aeruginosa and skin fibroblast conditioned medium. However, the ratios of the expression levels of pro‐inflammatory genes to anti‐inflammatory gene il‐10 was increased markedly in P. aeruginosa infected wounds and macrophages compared with that in control groups, and P. aeruginosa prolonged the presence of M1 macrophages in the wounds. These data demonstrated that P. aeruginosa in diabetic wounds activates a mixed M1/M2 macrophage phenotype with an excessive activation of M1 phenotype or relatively inadequate activation of M2 phenotype.
A prospective, multi‐center study of the chocolate balloon in femoropopliteal peripheral artery disease: The Chocolate BAR registry
Authors: Mustapha Jihad A. , Lansky Alexandra , Shishehbor Mehdi , Miles McClure John , Johnson Sarah , Davis Thomas , Makam Prakash , Crowder William , Konstantino Eitan , Attaran Robert R. ,   the Chocolate Bar Investigators
Published: March 2018

AbstractThe Chocolate BAR study is a prospective multicenter post‐market registry designed to evaluate the safety and performance of the Chocolate percutaneous transluminal angioplasty balloon catheter in a broad population with symptomatic peripheral arterial disease. The primary endpoint is acute procedural success (defined as ≤30% residual stenosis without flow‐limiting dissection); secondary long‐term outcomes include freedom from target lesion revascularization (TLR), major unplanned amputation, survival, and patency. A total of 262 patients (290 femoropopliteal lesions) were enrolled at 30 US centers between 2012 and 2014. The primary endpoint of procedure success was achieved in 85.1% of cases, and freedom from stenting occurred in 93.1%. Bail out stenting by independent adjudication occurred in 1.6% of cases and there were no flow limiting dissections. There was mean improvement of 2.1 Rutherford classes (±1.5) at 12‐months, with 78.5% freedom from TLR, 97.2% freedom from major amputation, and 93.3% freedom from all‐cause mortality. Core Lab adjudicated patency was 64.1% at 12 months. Use of the Chocolate balloon in an “all‐comers” population achieved excellent procedural outcomes with low dissection rates and bailout stent use.
Successive relaying for large MIMO amplify‐and‐forward relay networks
Authors: Peng Hong , Su Changran , Zhang Yu 
Published: March 2018

SummaryIn this paper, we consider a large relay network with one source, K relays and M users, where the source and relays are equipped with W and N antennas, respectively. We propose an amplify‐and‐forward successive relaying protocol in which the relays are divided into 2 groups to successively help transmission to M users. Achievable sum rate of the proposed protocol is derived and found to scale as
when N and M are fixed and K→∞ . On the other hand, when M and K are fixed and N→∞, the achievable sum rate scales as
. Therefore, the scaling law of the achievable sum rate coincides with the capacity scaling law of the considered network. Then, both precoding at the source and grouping of the relay nodes are jointly optimized to further improve the proposed protocol. Numerical results show that the proposed successive relaying protocol can outperform the conventional 2‐slot relaying protocol and the proposed joint optimization scheme for source precoding and relay grouping bring considerable rate gain.
Synthesis, Electrochemistry, and Optical Properties of Half‐Sandwich Ruthenium Complexes Bearing Triarylamine‐Anthracenes
Authors: Kovalski Eduard , Korb Marcus , Hildebrandt Alexander 
Published: March 2018

AbstractInvited for the cover of this issue is the group of Alexander Hildebrandt from Technische Universität Chemnitz, Germany. The cover image shows a light‐operated switch, which takes the complex between the mono‐oxidized and dicationic states reversibly.
Purification of bacterial inulinase in aqueous two‐phase systems
Authors: Temkov Mishela , Strinska Hristina , Dobrev Georgi , Velickova Elena , Muresan Vlad , Krastanov Albert 
Published: March 2018

AbstractIn this study, extracellular inulinase from Bacillus sp. 11/3 was partially purified and concentrated using aqueous two‐phase system (ATPS). Two different phase forming salts and four types of polyethylene glycol (PEG) were used. Binodal curves and tie‐length lines (TLLs) for eight ATPS were developed. For inulinase purification, concentrations of PEG and salt according to binodal curves (between 17 and 26%) were chosen. All ATPSs for inulinase purification were characterized. An ATPS consisted of 26% PEG1000 and 26% MgSO4 was found to be the most suitable for inulinase purification. This ATPS has 28.47% TLL, 1.03 of volume ratio, purification factor of 4.65 fold and recovery yield of 66.17%. On the SDS‐PAGE electrophoresis two protein bands with molecular weight of around 24 and 56 kDa were observed. The partially purified enzymes had optimal activity at pH 8.0 and 6.5, optimal temperature at 30 and 70°C and kinetic parameters Km = 26.32 mmol and Vmax = 526 mmol/min.
Synergistic effect of carbon and phosphorus flame retardants in rigid polyurethane foams
Authors: Chen Xiao‐Yu , Huang Zong‐Hou , Xi Xiu‐Qi , Li Jia , Fan Xin‐Yu , Wang Zhan 
Published: March 2018

SummaryTwo kinds of carbon and phosphorus synergistic system used to improve the flame retardancy of rigid polyurethane foams (RPUF) were studied. One is the synergistic effect of expandable graphite and guanidinium phosphate; the other is red phosphorus and guanidinium phosphate. The flame retardant properties and mechanical properties of these composites were investigated by limiting oxygen index, cone calorimeter test, as well as tension and compression test. These 2 groups of mixed inorganic flame retardants can greatly improve the flame retardancy of RPUF composites, as the limiting oxygen index increases from 20.1% to about 33% and the HRR reduces from 395 kW/m2 to below 200 kW/m2. It provides a convenient and inexpensive way to obtain RPUF with demanding properties.
Practical management of ibrutinib in the real life: Focus on atrial fibrillation and bleeding
Authors: Boriani Giuseppe , Corradini Paolo , Cuneo Antonio , Falanga Anna , Foà Robin , Gaidano Gianluca , Ghia Paolo Prospero , Martelli Maurizio , Marasca Roberto , Massaia Massimo , Mauro Francesca Romana , Minotti Giorgio , Molica Stefano , Montillo Marco , Pinto Antonio , Tedeschi Alessandra , Vitolo Umberto , Zinzani Pier Luigi 
Published: March 2018

AbstractThe Bruton tyrosine kinase inhibitor ibrutinib (IB) has attained an important role in the treatment of patients with chronic lymphocytic leukaemia, mantle cell lymphoma, and Waldenström macroglobulinemia, significantly improving clinical outcomes. However, IB therapy has been associated with an increased risk of atrial fibrillation (AF) and bleeding. We report on the expert opinion that a group of Italian haematologists, cardiologists, and pharmacologists jointly released to improve the practical management of patients at risk for AF and bleeding during treatment with IB. A proper pretreatment assessment to identify patients who are at a higher risk, careful choice of concomitant drugs, regular monitoring, and multispecialist approach were characterized as the main principles of clinical management of these patients. For patients developing AF, anticoagulant and antiarrhythmic therapy must be guided by considerations about efficacy, safety, and risk of pharmacokinetic interactions with IB. For patients experiencing bleeding or requiring procedures that increase the risk of bleeding, considerations about platelet turnover, IB‐related platelet dysfunctions, and bleeding worsening by concomitant anticoagulants or antiplatelet agents provide clues to manage bleeding. Overall, AF and bleeding are manageable clinical events in patients receiving IB, not requiring drug interruption in most cases. Preexisting AF should not represent an absolute contraindication to IB therapy. For each patient candidate for IB, strategies of risk assessment and mitigation may allow to exploit the life‐saving effects of in chronic lymphocytic leukaemia and mantle cell lymphoma.
Phase Transitions and Pattern Formation in Chemo‐Responsive Gels and Composites
Authors: Xiong Yao , Dayal Pratyush , Balazs Anna C. , Kuksenok Olga 
Published: March 2018

AbstractDesign of multifunctional materials often requires the chemical functionalization enabling the material to respond to a variety of stimuli. Herein, we focus on modeling of functionalized chemo‐responsive gels and composites; functionalization alters the volume phase transitions allowing system to undergo structural reconfiguration. For instance, we consider the volume phase transitions in photo‐sensitive hydrogels functionalized with two different types of chromophores that either alter the hydrophobicity of the illuminated sample or cause these samples to heat up. We then focus on gels that are driven by the oscillatory Belousov‐Zhabotinsky reaction and show that chemically mediated interactions among these gels drive them to self‐aggregate in a well‐defined manner. Finally, we focus on the self‐oscillating composite that does not contain oscillatory chemically reactions. In all these examples, effective control over the volume phase transitions is achieved through the combination of chemical functionalization and external stimuli, extending the potential utility of the host materials.
Application of high‐resolution array platform for genome‐wide copy number variation analysis in patients with nonsyndromic cleft lip and palate
Authors: da Silva Heglayne Pereira Vital , Oliveira Gustavo Henrique de Medeiros , Ururahy Marcela Abbott Galvão , Bezerra João Felipe , de Souza Karla Simone Costa , Bortolin Raul Hernandes , Luchessi André Ducati , Silbiger Vivian Nogueira , Lima Valéria Morgiana Gualberto Duarte Moreira , Leite Gisele Correia Pacheco , Brito Maria Edinilma Felinto , Ribeiro Erlane Marques , Gil‐da‐Silva‐Lopes Vera Lúcia , de Rezende Adriana Augusto 
Published: March 2018

BackgroundAlthough more than 14 loci may be involved in the development of nonsyndromic cleft lip and palate (NSCLP), the etiology has not been fully elucidated due to genetic and environmental risk factor interactions. Despite advances in identifying genes associated with the NSCLP development using traditional genetic mapping strategies of candidate genes, genome‐wide studies, and epidemiologic and linkage analysis, microarray techniques have become important complementary tools in the search for potential causative oral clefts genes in genetic studies. Microarray hybridization enables scanning of the whole genome and detecting copy number variants (CNVs). Although common benign CNVs are often smaller, with sizes smaller than 20 kb, here we reveal small exonic CNVs based on the importance of the encompassed genes in cleft lip and palate phenotype.MethodsMicroarray hybridization analysis was performed in 15 individuals with NSCLP.ResultsWe identified 11 exonic CNVs affecting at least one exon of the candidate genes. Thirteen candidate genes (COL11A1–1p21; IRF6–1q32.3; MSX1–4p16.2; TERT–5p15.33; MIR4457–5p15.33; CLPTM1L–5p15.33; ESR1–6q25.1; GLI3–7p13; FGFR–8p11.23; TBX1–22q11.21; OFD–Xp22; PHF8–Xp11.22; and FLNA–Xq28) overlapped with the CNVs identified.ConclusionsConsidering the importance to NSCLP, the microdeletions that encompass MSX1, microduplications over TERT, MIR4457, CLPTM1L, and microduplication of PHF8 have been identified as small CNVs related to sequence variants associated with oral clefts susceptibility. Our findings represent a preliminary study on the clinical significance of small CNVs and their relationship with genes implicated in NSCLP.
Study on the molecular recognition action of lamivudine by human serum albumin
Authors: Zhang Hua‐xin , Zhou Dan , Xia Qing‐hua 
Published: March 2018

AbstractIn this work, the interaction of an anti‐HIV drug lamivudine and human serum albumin (HSA) was studied by multispectroscopic and molecular modeling methods. The fluorescence emission spectra showed that the fluorescence of HSA was quenched by lamivudine through static mechanism with HSA‐lamivudine complex produced at ground state. According to the binding equilibriums observed at 4 different temperatures, the number of binding site, binding constant, enthalpy change, entropy change, and Gibbs free energy change of the interaction were calculated. The results indicated that there was only 1 main binding site under present concentration condition, and then, the location of this binding site was ascertained by molecular probe experiments using warfarin and ibuprofen as site markers. The interaction was a spontaneous and exothermic process. Hydrogen bonds and van der Waals force were the major power that fixed lamivudine on Sudlow's site I in subdomain IIA of HSA molecule. The distance between donor and acceptor was determined by Förster's nonradiative fluorescence resonance energy transfer theory. Circular dichroism spectra exhibited the alteration of HSA's secondary structures. Molecular modeling investigation revealed the structure of HSA‐lamivudine complex, including the conformation of lamivudine in binding site, the amino residues close to lamivudine, and the interaction forces between receptor and ligand. The study may be beneficial to therapists in understanding the distribution of lamivudine in vivo and explaining its drug‐resistant mechanism in clinical diagnosis.
Quantitative analysis of hepatic iron in patients suspected of coexisting iron overload and steatosis using multi‐echo single‐voxel magnetic resonance spectroscopy: Comparison with fat‐saturated multi‐echo gradient echo sequence
Authors: Lin Huimin , Fu Caixia , Kannengiesser Stephan , Cheng Shu , Shen Jun , Dong Haipeng , Yan Fuhua 
Published: March 2018

BACKGROUNDThe coexistence of hepatic iron and fat is common in patients with hyperferritinemia, which plays an interactive and aggressive role in the progression of diseases (fibrosis, cirrhosis, and hepatocellular carcinomas).PURPOSETo evaluate a modified high‐speed T2‐corrected multi‐echo, single voxel spectroscopy sequence (HISTOV) for liver iron concentration (LIC) quantification in patients with hyperferritinemia, with simultaneous fat fraction (FF) estimation.STUDY TYPERetrospective cohort study.POPULATIONThirty‐eight patients with hyperferritinemia were enrolled.FIELD STRENGTH/SEQUENCEHISTOV, a fat‐saturated multi‐echo gradient echo (GRE) sequence, and a spin echo sequence (FerriScan) were performed at 1.5T.ASSESSMENTR2 of the water signal and FF were calculated with HISTOV, and
values were derived from the GRE sequence, with R2 and LIC from FerriScan serving as the references.STATISTICAL TESTSLinear regression, correlation analyses, receiver operating characteristic analyses, and Bland‐Altman analyses were conducted.RESULTSAbnormal hepatic iron load was detected in 32/38 patients, of whom 10/32 had coexisting steatosis. Strong correlation was found between
and FerriScan‐LIC (R2 = 0.861), and between HISTOV‐R2_water and FerriScan‐R2 (R2 = 0.889). Furthermore, HISTOV‐R2_water was not correlated with HISTOV‐FF. The area under the curve (AUC) for HISTOV‐R2_water was 0.974, 0.971, and 1, corresponding to clinical FerriScan‐LIC thresholds of 1.8, 3.2, and 7.0 mg/g dw, respectively. No significant difference in the AUC was found between HISTOV‐R2_water and
at any of the LIC thresholds, with P‐values of 0.42, 0.37, and 1, respectively. HISTOV‐LIC showed excellent agreement with FerriScan‐LIC, with a mean bias of 0.00 ± 1.18 mg/g dw, whereas the mean bias between GRE‐LIC and FerriScan‐LIC was 0.53 ± 1.49 mg/g dw.DATA CONCLUSIONHISTOV is useful for the quantification and grading of liver iron overload in patients with hyperferritinemia, particularly in cases with coexisting steatosis. HISTOV‐LIC showed no systematic bias compared with FerriScan‐LIC, making it a promising alternative for iron quantification.Level of Evidence: 3Technical Efficacy Stage 2J. Magn. Reson. Imaging 2018.
Clinical presentations, diagnosis, and management of arrhythmias associated with cardiac tumors
Authors: Jayaprakash Shenthar 
Published: March 2018

AbstractCardiac tumors are a rare cause of arrhythmias in clinical practice. They can cause a broad spectrum of arrhythmias, from low‐grade ectopics to incessant ventricular tachycardias, including sudden cardiac arrest. Both primary and secondary cardiac tumors can produce arrhythmias, but not all tumors cause arrhythmias. Although cardiac tumors can cause arrhythmias in fetuses and older adults alike, only specific cardiac tumors are the underlying cause of arrhythmia in different age groups. This article reviews various cardiac tumors that are associated with arrhythmias, their clinical presentations, diagnostic features, and management.