bluuebunny/crossref_metadata_2025_split huggingface dataset:
High impedance alert with safety switching: An unreported hazard of hybrid pacing systems
Authors: Karnik Ankur A. , Helm Robert H. , Gaskill Matthew D. , Dermovsesian Arlene , Monahan Kevin M. 
Published: April 2019

AbstractSeveral Boston Scientific pacemaker models have a known issue with intermittent oversensing of the minute ventilation sensor when paired with non‐Boston Scientific leads. Several of our patients with these hybrid systems have had transient out of range impedances and oversensing after safety switching which we suspected may be related. A retrospective analysis of 395 patients who had pacemakers implanted between 2015‐2017 found that transient out of range impedances with safety switching was present in 9% of Boston Scientific pacemakers paired with Abbott or Medtronic leads compared with 0% in other device‐lead combinations (P = 0.0089). We postulate that the root cause of the minute ventilation oversensing and transient high impedance issue is the same, a header‐lead interaction from low‐level incompatibility. Recognizing this issue is critical to prevent unnecessary lead revisions or extractions as it can be prevented with a simple reprogramming of lead pace/sense configuration.
Update on catheter ablation research from The 2019 European Heart Rhythm Association Congress
Authors: Santangeli Pasquale , Ellenbogen Kenneth A. 
Published: April 2019

AbstractThe 2019 European Heart Rhythm Association (EHRA) scientific meetings released several Late Breaking Clinical Trials that define important results for the fields of catheter ablation of atrial fibrillation (AF) and ventricular tachycardia (VT). Three independent multicenter randomized controlled trials have confirmed that AF ablation with point‐by‐point radiofrequency energy or cryoballoon technology are both equally and highly effective, and significantly superior to antiarrhythmic drug therapy in reducing recurrent AF episodes and preventing arrhythmia‐related hospitalizations. Edoxaban has been shown a viable option for periprocedural oral anticoagulation in patients undergoing catheter ablation of AF in a large multicenter randomized study, with outcomes similar to uninterrupted warfarin. Important mechanistic studies have evaluated the electrophysiologic features of concealed substrate in reperfused myocardial infarction (MI) with small electrode mapping, and investigated the longitudinal evolution of the arrhythmogenic substrate following acute MI. Finally, encouraging results from multicenter observational studies support the emerging role of imaging integration with cardiac magnetic resonance or computed tomography to guide substrate ablation of VT. This article will provide an update on some of the most relevant studies in the field of catheter ablation of AF and VT presented at the latest EHRA conference.
Magnetic resonance imaging abnormalities in the basal interventricular septum of patients with left ventricular outflow tract arrhythmias
Authors: Reithmann Christopher , Kling Theresia , Herkommer Bernhard , Fiek Michael , Ulbrich Michael 
Published: April 2019

AbstractIntroductionConcealed structural abnormalities were detected by delayed enhancement ‐ magnetic resonance imaging (DE‐MRI) in patients with apparently idiopathic tachycardia of left ventricular (LV) origin. Basal septal fibrosis was evaluated as a potential arrhythmia substrate in patients with left ventricular outflow tract (LVOT) arrhythmias.Methods and ResultsA total of 22 patients with LVOT arrhythmias, including frequent monomorphic premature ventricular complexes (PVCs) in 15 patients and ventricular tachycardia (VT) in 7 patients, underwent catheter ablation and DE‐MRI. A total of 19 patients with frequent PVCs and 17 patients with idiopathic VT of other origin served as a control group. Basal septal intramural fibrosis as thin strip‐shaped intramyocardial DE or as marked intramyocardial DE involving >25% of wall thickness was detected more frequently in patients with LVOT arrhythmias (41% and 32%) than in patients with non LVOT arrhythmias (14% and 3%). After successful ablation, 4/16 patients with basal septal intramural fibrosis and LVOT PVCs (n = 3) or LVOT VT (n = 1) compared with no patient without basal septal fibrosis experienced episodes of sustained VT with similar or different QRS morphology resulting in ICD therapy in three patients. Follow‐up DE‐MRI after PVC ablation (17 ± 7 months) revealed an increase in LV ejection fraction from 49 ± 5% to 56 ± 5% (n = 9) but the amount of septal DE remained unchanged.ConclusionsBasal septal intramural fibrosis may serve as the arrhythmia substrate in a substantial part of patients with premature ventricular complexes (PVCs) and VT originating from the LVOT and identifies patients with continued risk for VT recurrence after initially successful ablation of LVOT arrhythmias.
The role and mechanism of transforming growth factor beta 3 in human myocardial infarction‐induced myocardial fibrosis
Authors: Xue Ke , Zhang Jun , Li Cong , Li Jing , Wang Cong , Zhang Qingqing , Chen Xianlu , Yu Xiaotang , Sun Lei , Yu Xiao 
Published: April 2019

AbstractTransforming growth factor beta (TGFβ) plays a crucial role in tissue fibrosis. A number of studies have shown that TGFβ3 significantly attenuated tissue fibrosis. However, the mechanism involved in this effect is poorly understood. In this study we found that the expression level of TGFβ3 was higher in human myocardial infarction (MI) tissues than in normal tissues, and interestingly, it increased with the development of fibrosis post‐myocardial infarction (post‐MI). In vitro, human cardiac fibroblasts (CFs) were incubated with angiotensin II (Ang II) to mimic the ischaemic myocardium microenvironment and used to investigate the anti‐fibrotic mechanism of TGFβ3. Then, fibrosis‐related proteins were detected by Western blot. It was revealed that TGFβ3 up‐regulation attenuated the proliferation, migration of human CFs and the expression of collagens, which are the main contributors to fibrosis, promoted the phenotype shift and the cross‐linking of collagens. Importantly, the expression of collagens was higher in the si‐smad7 groups than in the control groups, while silencing smad7 increased the phosphorylation level of the TGFβ/smad signalling pathway. Collectively, these results indicated that TGFβ3 inhibited fibrosis via the TGFβ/smad signalling pathway, possibly attributable to the regulation of smad7, and that TGFβ3 might serve as a potential therapeutic target for myocardial fibrosis post‐MI.
Peri‐implant crevicular fluid proteome before and after adjunctive enamel matrix derivative treatment of peri‐implantitis
Authors: Esberg Anders , Isehed Catrine , Holmlund Anders , Lundberg Pernilla 
Published: April 2019

AbstractAimThe aim of this study was to explore which peri‐implant crevicular fluid (PICF) protein pattern is associated with the active peri‐implantitis process.Materials and methodsPeri‐implant crevicular fluid from 25 peri‐implantitis sites were subjected to proteomic analysis using liquid chromatography–tandem mass spectrometry before and at 3, 6 and 12 months after treatment, to identify associations between PICF protein pattern and implant loss, bleeding on probing, pocket depth and enamel matrix derivative (EMD) treatment.ResultsClustering of subjects based on their 3–12 months PICF proteomic profiles by principal component analysis defined two major clusters. Cluster 2 differentiated from cluster 3 by 52 proteins (R2 = 90%, Q2 = 80%) and belonging to cluster 2 was associated with implant loss (p = 0.009) and bleeding on probing (p = 0.001). Cluster 3 was associated with implant survival and EMD treatment (p = 0.044).ConclusionHere, we demonstrate that a specific PICF proteomic profile associates with active peri‐implantitis process and implant loss.
Quantifying massive outbreaks of the defoliator mothOrmiscodes amphimonein deciduousNothofagus‐dominated southern forests using remote sensing time series analysis
Authors: Estay Sergio A. , Chávez Roberto O. , Rocco Ronald , Gutiérrez Alvaro G. 
Published: April 2019

AbstractForest insect outbreaks are one of the major biotic disturbances on natural and artificial landscapes. Although abundant literature of insect outbreaks exists in the Northern Hemisphere, studies for the Southern Hemisphere are rare. Recently, massive outbreaks of the native mothOrmiscodes amphimone(Fabricius) (Lepidoptera: Hemileucinae) have been reported in the southern cone of South America. TheseO. amphimoneoutbreaks have defoliated large areas of temperate forests, raising great concern among local inhabitants, but yet the spatio‐temporal patterns of these events have not been evaluated. Here, we quantify the extension of the massiveO. amphimoneoutbreaks occurred in the Aysén region (southern Chile) in the period 2000–2015 using a novel remote sensing approach and field data. Remote sensing detections were strongly in agreement with field observations and showed that massive outbreaks ofO. amphimoneare among the largest biotic disturbances in the forests of the Southern Hemisphere. Considering only field‐confirmed outbreaks, the defoliated area reached 164,000 hectares in total between 2000 and 2015. The estimation of the spatial impact ofO. amphimone, and its recurrence, represents the first step for the search of management alternatives of this massive disturbance.
Efficacy and safety of Rhizoma curcumea longae with respect to improving the glucose metabolism of patients at risk for cardiovascular disease: a meta‐analysis of randomised controlled trials
Authors: Huang J. , Qin S. , Huang L. , Tang Y. , Ren H. , Hu H. 
Published: April 2019

AbstractBackgroundClinical evidence suggests that curcuminoids, as a natural polyphenol, can provide support for cardioprotection and glucose metabolism. This meta‐analysis assessed the efficacy and safety of curcumin with respect to improving glucose metabolism in patients with cardiovascular risk factors.MethodsFour databases (PubMed, Cochrane Library, Web of Science and Embase) were searched up to June 2018. The inclusion criteria included (i) randomised controlled trials (RCT) and (ii) subjects with risk factors for cardiovascular disease supplemented with curcumin and curcuminoids. A random‐effects model and a standardised mean difference with a 95% confidence interval were used to perform quantitative data synthesis. Sensitivity and subgroup analyses were conducted to assess the effects.ResultsFourteen eligible RCT with 1277 subjects were included. In the overall analyses, curcumin led to significant decreases in fasting blood glucose (FBG), glycated haemoglobin (HbA1c) and homeostatic model assessment of insulin resistance (HOMA‐IR). The subgroup analyses suggested that curcumin or combined curcuminoids were more effective at reducing FBG and HbA1c in type 2 diabetes patients than in individuals with metabolic syndrome. Supplementation with curcuminoids at doses ≥300 mg day−1 showed significant decreases in FBG, HbA1c and HOMA‐IR. The effects of supplementation on FBG, HbA1c and HOMA‐IR were more significant over long periods (≥12 weeks) than short periods. Curcumin and curcuminoids were well tolerated, with no serious adverse events.ConclusionsCurcumin or combined curcuminoids could exert cardioprotective effects in patients at risk for cardiovascular disease by improving glucose metabolism. However, further high‐quality studies and larger sample sizes are required to confirm these results.
Gender‐related cost discrepancies in a cohort of 110 facial moisturizers
Authors: Manatis‐Lornell Athena J. , Marks Dustin H. , Hagigeorges Dina , Okhovat Jean‐Phillip , Senna Maryanne M. 
Published: April 2019

AbstractBackgroundGender‐related price inequalities for over‐the‐counter dermatologic products such as shampoos and conditioners, razors, deodorants, and lotions remain prevalent in the marketplace. This trend has also been found to apply to topical minoxidil, a common treatment for male and female pattern hair loss.ObjectiveWe sought to identify the gender‐related price discrepancies of facial moisturizers, which are routinely recommended by dermatologists.MethodsThree online retailers (Amazon, Target, and Walmart) were surveyed for available facial moisturizers in October 2018. Facial moisturizers were classified as men's, women's, or gender‐neutral based on three specific marketing variables: language, container color/graphics, and container curvature/shape.ResultsIn total, 110 facial moisturizers were included in this analysis. Of the 54 facial moisturizers evaluated for men, 47 (87%) contained the word “men” within the marketing language, while only three of 56 (5.4%) facial moisturizers targeted at women were explicitly labeled “for women.” No statistically significant difference was found between the number of facial moisturizers listed as fragrance‐free, SPF‐containing, anti‐aging, or those labeled as sensitive, hypoallergenic, or dermatologist recommended between the two groups. However, facial moisturizers marketed to women were on average $3.09 more per ounce than those marketed to men. A two‐tailed t test revealed a statistically significant difference between the price per ounce of facial moisturizers for men ($6.20) and those for women ($9.29) (P = 0.013).ConclusionFacial moisturizers marketed to women were found to be significantly more expensive than comparable facial moisturizers marketed to men.
Aberrant personality tendencies and academic success throughout engineering education
Authors: Bipp Tanja , Kleingeld Ad , Snijders Chris 
Published: April 2019

AbstractObjectiveIn a longitudinal field study, we investigated the predictive associations between six aberrant personality tendencies (schizotypal, avoidant, borderline, antisocial, narcissistic, obsessive‐compulsive) and academic success of science, technology, engineering, and mathematics students.MethodBachelor students of Industrial Engineering at a Dutch technical university (N = 432, Mage = 18.45; 87.3% male) filled out the NEO‐PI‐R and aberrant tendencies were operationalized by the five‐factor model (FFM) compound technique. Indicators of academic achievement (grades) and persistence (credit points earned per year, re‐enrollment, study duration) were made available by the academic office.ResultsValidities across the 3 years of the study program consistently support the role of two aberrant tendencies: Individuals with high antisocial tendency reached lower academic achievement, took longer to finish their study, and had a higher risk of dropout. The obsessive‐compulsive tendency was associated with higher grade‐point average, faster study progress, and higher retention rates and effects were still visible while controlling for known predictors (high school grades, Conscientiousness). Contrary to our expectations, we found no evidence for inverted U‐shaped relationships.ConclusionsWe used the compound technique for aberrant tendencies based on the FFM in the academic context and our findings support the importance of personality‐based psychopathological tendencies for academic success.
Neuroticism and interpersonal perception: Evidence for positive, but not negative, biases
Authors: Hannuschke Marianne , Gollwitzer Mario , Geukes Katharina , Nestler Steffen , Back Mitja 
Published: April 2019

AbstractObjectivePersonality dispositions predict how individuals perceive, interpret, and react to social interactions with others. A still unresolved question is (a) whether these personality‐congruent interpersonal perceptions reflect perception biases, which occur when perceivers' dispositions systematically predict deviations between perceivers' and other people's perceptions of the same interaction, and/or selection effects, which occur when perceivers' dispositions predict their selection of interaction partners, and (b) whether these effects feed back into perceivers' personality.MethodData from 110 psychology freshmen involving repeated assessments of Neuroticism and repeated interpersonal perceptions of social interactions with fellow students were analyzed to address these questions, focusing on Neuroticism.ResultsThere is evidence for a Neuroticism‐related positivity bias in interpersonal perceptions (i.e., perceivers high in Neuroticism tended to make more positive judgments of others' sociability and warmth), but little evidence for personality‐congruent selection effects (i.e., Neuroticism‐related preferences for interaction partners). The positivity bias did not predict intrapersonal changes in Neuroticism over time, but the selection of specific interaction partners did.ConclusionsThese findings help to shed light on the interpersonal perception dynamics of Neuroticism in a real‐life context and add to our understanding of the psychological mechanisms underlying the interplay of personality and interpersonal perceptions.
Risky Sexual Behavior among Arrested Adolescent Males: The Role of Future Expectations and Impulse Control
Authors: Knowles Alissa , Rinehart Jenny K. , Steinberg Laurence , Frick Paul J. , Cauffman Elizabeth 
Published: April 2019

The current study evaluates two predictors of adolescent sexual risk‐taking, specifically whether impulse control or future expectations predict condom use and casual sex. We examine whether risky sex occurs among youth who tend to act without thinking about the future, or instead, youth who report low future expectations. We consider these relations longitudinally among a sample of sexually active justice‐involved adolescent males (N = 752, M age = 15.58) a group at heightened risk for sexual risk‐taking. We found that optimistic expectations for the future predict a higher likelihood of engaging in consistent condom use, whereas high impulse control is related to a lower likelihood of casual sex. Implications for intervention and research on positive sexual health are discussed.
Quality of methods and reporting in association studies of chronic periodontitis and IL1A−889 and IL1B+3953/4 SNPs: A systematic review
Authors: Citterio Filippo , Romano Federica , Ferrarotti Francesco , Gualini Giacomo , Aimetti Mario 
Published: April 2019

ObjectiveThe aim of this systematic review was to evaluate the quality of reporting and methodology in genetic association studies between IL1A −889 and IL1B +3954 polymorphisms and chronic periodontitis.BackgroundEvidence provided by periodontal research on genetic risk factors is of uttermost importance in clinical practice as a possible diagnostic and prognostic tool for periodontitis. Inadequate reporting of results as well as high risk of bias due to methodological inconsistency hampers the integration of evidence in terms of clinical applicability.MethodsThis review includes case‐control studies in humans published between 1997 and July 2017. Searching was conducted through MEDLINE, EMBASE, and search handing. Specific scoring systems have been developed to evaluate the quality of methods and reporting. Each article was scored according to its adequacy, and then, the total number and the percentage of items positively qualified for both methods and reporting were calculated. The quality of methods in studies scoring 0‐6, 7‐12, and 13‐16 was, respectively, considered poor, moderate, and good. For reporting, scores of 0‐9, 10‐18, and 19‐26 were deemed of poor, moderate, and good quality, respectively. Pearson's correlation coefficient was calculated to explore the correlation between the year of publication and the quality in terms of methods and reporting.ResultsFrom the 531 screened studies, 52 met the inclusion criteria and were thus included in the study. The quality of methods and reporting of published genetic association papers on IL1 and chronic periodontitis is moderate. On a scale from 0 to 16, the mean score for methods of the reviewed studies was 8.19 ± 1.93. The items more frequently considered inadequate concerned the handling of confounders in statistical analysis, especially oral hygiene habits, socioeconomic status, subgingival colonization of specific periodontal pathogens, and stress. A significant positive correlation was found between the year of publication and the quality scores in terms of method (r = 0.401, P = 0.003). In terms of reporting, the mean score was 14.83 ± 3.04 on a scale from 0 to 26 and it was considered overall moderate. No statistically significant correlation was found between the year of publication and the quality of reporting (P = 0.266).ConclusionsThe association between IL1A −889 and IL1B +3954 polymorphisms and chronic periodontitis is questionable due to methodological inconsistency. Evidence arising from meta‐analysis is unreliable due to high risk of bias and moderate quality in terms of reporting.
‘Sistem te laže!’: the anti‐ruling class mobilisation of high school students in Bosnia and Herzegovina
Authors: Piersma Michiel J. 
Published: April 2019

AbstractThis article presents the case of a high school student‐led protest movement in the Bosnian towns of Jajce and Travnik. Over the course of 2016 and 2017, the students developed opposition to a plan for an ethnically segregated high school in Jajce. In Bosnia and Herzegovina, ethnicity is strongly politicised and limits the political activities of citizens to what is prescribed by the elites of their respective ethnic groups. In particular, Bosnian youth is often named as part of an apathetic ‘lost generation’ whose voices are smothered by this ethno‐political framework. I argue that the political agency of ordinary young Bosnians should not be neglected, since the formulations of their relationship with the state form meaningful political activities. The student protests in Jajce and Travnik are telling examples of their political agency. In an analysis of the protest movement's actions, I show that the students adopt a narrative that opposes the ruling political class and their prevalence of personal interests over the future of younger generations.
Taking Nature Graciously: A Thomistic Perspective on Habits
Authors: Sullivan Ezra 
Published: April 2019

AbstractWhen speaking of the odd behavior of a particular individual, it is common for people to say something like, “Well, I am just made that way,” or, “He can't help it; that's the way he is.” On the other hand, when considering future vistas for action, some suppose that that, everything in life can be a matter of choice, that we can choose our own gender, ethnicity, or identity. It seems to me that there are theological parallels to these anthropological positions. First, similar to mechanical determinism, some believe in a determined mechanism of sin that destroys human nature and makes free choice an illusion. Second, similar to views that human fulfillment is simply a matter of exercising our will, some argue that graced happiness is merely an extension of nature. To all of these positions, Aquinas has a response.
Logics and Logistics for Future Research: Appropriately Interpreting the Emotional Landscape of Multicultural Negotiation
Authors: Rees Laura , Kopelman Shirli 
Published: April 2019

AbstractTo invigorate future teaching and research, this article discusses theoretical approaches and empirical opportunities to better understand emotional dynamics in negotiation settings across cultural contexts. We adopt a culturally informed logic of appropriateness (Kopelman, ) to shed light on emerging and underexplored topics in this domain. The goal of this article is to inspire scholars worldwide to engage in rigorous empirical investigations of the antecedents, consequences, mechanisms, boundary conditions, and evidence‐based strategies in the combined domain of negotiation, culture, and emotion through research, teaching, and practice.