bluuebunny/crossref_metadata_2025_split huggingface dataset:
Gender differences in attitudes and attributes of people using therapeutic shoes for diabetic foot complications
Authors: Jarl Gustav , Alnemo John , Tranberg Roy , Lundqvist Lars‐Olov 
Published: March 2019

AbstractBackgroundTherapeutic shoes can prevent diabetic foot reulcerations but their use is complicated by the fact that shoes have psychological and social meanings, which is believed to put a larger burden on women than men. The aim was to compare attitudes and attributes of women and men using therapeutic shoes for diabetic foot complications.MethodsA questionnaire was posted to 1230 people with diabetes who had been fitted with therapeutic shoes. Women's and men's answers were compared using t‐tests, Mann–Whitney U tests and chi‐square tests with Fischer's exact tests. P‐values < 0.05 were considered statistically significant.ResultsQuestionnaires from 443 (36.0%) respondents (294 men, 149 women, mean age 69.2 years) were analyzed. More men than women (p < 0.05) had paid employment (20.4% vs 9.4%), had someone who reminded them to wear their therapeutic shoes (27.6% vs 10.0%), and had a history of foot ulcers (62.9% vs 46.3%) or minor amputation (17.7% vs 6.7%). More women than men received disability pension (18.8% vs 10.2%). Women reported worse general health, lower internal locus of control regarding ulcer prevention, and more negative attitudes to the appearance and price of therapeutic shoes and how they felt about wearing them in public. Other comparisons were non‐significant: other shoe attributes, education, diabetes type, current foot ulcers, major amputations, satisfaction with shoe services, understanding of neuropathy as a risk factor, locus of control regarding ulcer healing, belief in the shoes' efficacy to prevent and heal ulcers, worries about ulcer healing and new ulcerations, self‐efficacy, depression, shoe use/adherence, paying a fee for therapeutic shoes, and social support.ConclusionsMen had worse foot complications. Women had worse general health, lower internal locus of control regarding ulcer prevention, and more negative attitudes toward therapeutic shoes. Clinicians should pay more attention to their female patients' concerns. Future research and development should focus on improving the weight and appearance of therapeutic shoes, particularly for women. Research is also needed on how to facilitate the adaption and reevaluation process where patients change from viewing shoes purely as items of clothing to also viewing them as medical interventions.
Mucinous colorectal adenocarcinoma: clinical pathology and treatment options
Authors: Luo Cong , Cen Shuyi , Ding Guojun , Wu Wei 
Published: March 2019

AbstractMucinous colorectal adenocarcinoma is a distinct subtype of colorectal cancer (CRC) characterized by the presence of abundant extracellular mucin which accounts for at least 50% of the tumor volume. Mucinous colorectal adenocarcinoma is found in 10%–20% of CRC patients and occurs more commonly in female and younger patients. Moreover, mucinous colorectal adenocarcinoma is more frequently located in the proximal colon and diagnosed at an advanced stage. Based on its molecular context, mucinous colorectal adenocarcinoma is associated with the overexpression of mucin 2 (MUC2) and mucin 5AC (MUC5AC) proteins. At the same time, it shows higher mutation rates in the fundamental genes of the RAS/MAPK and PI3K/Akt/mTOR pathways. Mucinous colorectal adenocarcinoma also shows higher rates of microsatellite instability (MSI) than non‐mucinous colorectal adenocarcinoma which might correlate it with Lynch syndrome and the CpG island methylator phenotype. The prognosis of mucinous colorectal adenocarcinoma as to non‐mucinous colorectal adenocarcinoma is debatable. Further, the impaired responses of mucinous colorectal adenocarcinoma to palliative or adjuvant chemotherapy warrant more studies to be performed for a specialized treatment for these patients. In this review, we discuss the molecular background and histopathology of mucinous colorectal adenocarcinoma, and provide an update on its prognosis and therapeutics from recent literatures.
Recapitulating Parkinson's disease pathology in a three-dimensional human neural cell culture model
Authors: Taylor-Whiteley Teresa R. , Le Maitre Christine L. , Duce James A. , Dalton Caroline F. , Smith David P. 
Published: March 2019

ABSTRACT
Extensive loss of dopaminergic neurons and aggregation of the protein α-synuclein into ubiquitin-positive Lewy bodies represents a major neuropathological hallmark of Parkinson's disease (PD). At present, the generation of large nuclear-associated Lewy bodies from endogenous wild-type α-synuclein, translationally regulated under its own promoter in human cell culture models, requires costly and time-consuming protocols. Here, we demonstrate that fully differentiated human SH-SY5Y neuroblastoma cells grown in three-dimensional cell culture develop Lewy-body-like pathology upon exposure to exogenous α-synuclein species. In contrast to most cell- and rodent-based PD models, which exhibit multiple diffuse α-synuclein aggregates throughout the cytoplasm, a single large nuclear inclusion that is immunopositive for α-synuclein and ubiquitin is rapidly obtained in our model. This was achieved without the need for overexpression of α-synuclein or genetic modification of the cell line. However, phosphorylation of α-synuclein within these inclusions was not observed. The system described here provides an ideal tool to screen compounds to therapeutically intervene in Lewy body formation, and to investigate the mechanisms involved in disease progression in synucleinopathies.
Obesity Prevalence and Musculoskeletal Injury History in Probation Officers
Authors: MOTA JACOB A. , KERR ZACHARY Y. , GERSTNER GENA R. , GIULIANI HAYDEN K. , RYAN ERIC D. 
Published: March 2019

ABSTRACT

Purpose
The purpose of the present investigation was to identify 1) the prevalence of overweight and obesity and 2) factors associated with previous work-related musculoskeletal injury, and physical activity (PA) levels in North Carolina probation officers.

Methods
North Carolina probation officers (N = 1866) were sent a questionnaire on demographics, work history, injury history, and PA. A multivariable logistic regression model estimated the odds of reporting work-related musculoskeletal injury history within the past year, and multivariable ordinal logistic regression estimated the odds of reporting lower PA levels in the previous month. Odds ratios (OR) with 95% confidence intervals (CI) excluding 1.00 were deemed significant.

Results
Complete data were available for 1323 probation officers (70.9% completion rate; 46.5% female; mean ± SD age, 39.9 ± 10.0 yr). Officers that were classified as overweight and obese were 80.8% (body mass index [BMI] ≥ 25 kg·m−2), with 49.9% and 9.5% categorized as obese (BMI ≥ 30 kg·m−2) and severely obese (BMI ≥ 40 kg·m−2), respectively. Being older (1-yr increase; OR, 1.06; 95% CI, 1.04–1.09) and severely obese (compared to normally weighted; OR, 2.56; 95% CI, 1.19–5.51) was associated with a greater odds of sustaining a work-related musculoskeletal injury in the past year. A higher number of years of employment (1-yr increase; OR, 1.03; 95% CI, 1.01–1.04), being overweight or obese (compared to normal weight; OR, 1.57–3.22) and being female (compared with male: OR, 0.38; 95% CI, 0.31–0.47) was associated with the greater odds of lower PA levels in the previous month.

Conclusions
The prevalence of obesity is alarmingly high in probation officers, and is associated with a greater likelihood of sustaining previous work-related musculoskeletal injury and engaging in lower amounts of PA. Public safety administrators may consider worksite exercise/diet interventions and annual physical employment standards to combat obesity.
New Product Preannouncement: Phantom Products and the Osborne Effect
Authors: Rao Ram , Turut Ozge 
Published: March 2019

The mere preannouncement of a new product can affect consumer choice, thus complicating preannouncement strategy. This is because a preannounced product that is unavailable immediately can still be one of the alternatives in a consumer’s mind at the time of choice. Such unavailable products, also known as phantom products, influence the reference point that consumers compare alternatives to when making a choice, as has been widely demonstrated in experimental studies. Thus, in addition to encouraging consumers to postpone purchase in favor of a future product, preannouncement also changes their preference for the currently available products when consumers do not prefer to postpone. In this paper we explore preannouncement strategy by analyzing a model that incorporates the effect of new product preannouncement (NPP) on consumer preferences and compare the results with a benchmark case in which consumer preferences across the existing products are not influenced by preannouncement. We find that when we take into account the effect of NPP on consumer preferences across the existing products, although postponement of purchase by some consumers remains beneficial, the preference for the current product offering with a lower quality can suffer so much that the significant lowering of current profits is not offset by future gains. Thus, preannouncement may no longer be the optimal strategy for the firm with a lower-quality product, which in turn explains the “Osborne effect.” Our results also challenge the conventional wisdom in new product preannouncement literature. This paper was accepted by Juanjuan Zhang, marketing.
Analysis of the Attune tibial tray backside
Authors: Cerquiglini A. , Henckel J. , Hothi H. , Allen P. , Lewis J. , Eskelinen A. , Skinner J. , Hirschmann M. T. , Hart A. J. 
Published: March 2019

Objectives The Attune total knee arthroplasty (TKA) has been used in over 600 000 patients worldwide. Registry data show good clinical outcome; however, concerns over the cement-tibial interface have been reported. We used retrieval analysis to give further insight into this controversial topic. Methods We examined 12 titanium (Ti) PFC Sigma implants, eight cobalt-chromium (CoCr) PFC Sigma implants, eight cobalt-chromium PFC Sigma rotating platform (RP) implants, and 11 Attune implants. We used a peer-reviewed digital imaging method to quantify the amount of cement attached to the backside of each tibial tray. We then measured: 1) the size of tibial tray thickness, tray projections, peripheral lips, and undercuts; and 2) surface roughness (Ra) on the backside and keel of the trays. Statistical analyses were performed to investigate differences between the two designs. Results There was no evidence of cement attachment on any of the 11 Attune trays examined. There were significant differences between Ti and CoCr PFC Sigma implants and Attune designs (p < 0.05); however, there was no significant difference between CoCr PFC Sigma RP and Attune designs (p > 0.05). There were significant differences in the design features between the investigated designs (p < 0.05). Conclusion The majority of the earliest PFC Sigma designs showed evidence of cement, while all of the retrieved Attune trays and the majority of the RP PFC trays in this study had no cement attached. This may be attributable to the design differences of these implants, in particular in relation to the cement pockets. Our results may help explain a controversial aspect related to cement attachment in a recently introduced TKA design. Cite this article: A. Cerquiglini, J. Henckel, H. Hothi, P. Allen, J. Lewis, A. Eskelinen, J. Skinner, M. T. Hirschmann, A. J. Hart. Analysis of the Attune tibial tray backside: A comparative retrieval study. Bone Joint Res 2019;8:136–145. DOI: 10.1302/2046-3758.83.BJJ-2018-0102.R2.
A Role for Sensory end Organ-Derived Signals in Regulating Muscle Spindle Proprioceptor Phenotype
Authors: Wu Dawei , Schieren Ira , Qian Yingzhi , Zhang Chaolin , Jessell Thomas M. , de Nooij Joriene C. 
Published: March 2019

Proprioceptive feedback from Group Ia/II muscle spindle afferents and Group Ib Golgi tendon afferents is critical for the normal execution of most motor tasks, yet how these distinct proprioceptor subtypes emerge during development remains poorly understood. Using molecular genetic approaches in mice of either sex, we identified 24 transcripts that have not previously been associated with a proprioceptor identity. Combinatorial expression analyses of these markers reveal at least three molecularly distinct proprioceptor subtypes. In addition, we find that 12 of these transcripts are expressed well after proprioceptors innervate their respective sensory receptors, and expression of three of these markers, including the heart development moleculeHeg1, is significantly reduced in mice that lack muscle spindles. These data revealHeg1as a putative marker for proprioceptive muscle spindle afferents. Moreover, they suggest that the phenotypic specialization of functionally distinct proprioceptor subtypes depends, in part, on extrinsic sensory receptor organ-derived signals.SIGNIFICANCE STATEMENTSensory feedback from muscle spindle (MS) and Golgi tendon organ (GTO) sensory end organs is critical for normal motor control, but how distinct MS and GTO afferent sensory neurons emerge during development remains poorly understood. Using (bulk) transcriptome analysis of genetically identified proprioceptors, this work reveals molecular markers for distinct proprioceptor subsets, including some that appear selectively expressed in MS afferents. Detailed analysis of the expression of these transcripts provides evidence that MS/GTO afferent subtype phenotypes may, at least in part, emerge through extrinsic, sensory end organ-derived signals.
Diploid Genome Assembly of the Wine Grape Carménère
Authors: Minio Andrea , Massonnet Mélanie , Figueroa-Balderas Rosa , Castro Alvaro , Cantu Dario 
Published: March 2019

AbstractIn this genome report, we describe the sequencing and annotation of the genome of the wine grape Carménère (clone 02, VCR-702). Long considered extinct, this old French wine grape variety is now cultivated mostly in Chile where it was imported in the 1850s just before the European phylloxera epidemic. Genomic DNA was sequenced using Single Molecule Real Time technology and assembled with FALCON-Unzip, a diploid-aware assembly pipeline. To optimize the contiguity and completeness of the assembly, we tested about a thousand combinations of assembly parameters, sequencing coverage, error correction and repeat masking methods. The final scaffolds provide a complete and phased representation of the diploid genome of this wine grape. Comparison of the two haplotypes revealed numerous heterozygous variants, including loss-of-function ones, some of which in genes associated with polyphenol biosynthesis. Comparisons with other publicly available grape genomes and transcriptomes showed the impact of structural variation on gene content differences between Carménère and other wine grape cultivars. Among the putative cultivar-specific genes, we identified genes potentially involved in aroma production and stress responses. The genome assembly of Carménère expands the representation of the genomic variability in grapes and will enable studies that aim to understand its distinctive organoleptic and agronomical features and assess its still elusive extant genetic variability. A genome browser for Carménère, its annotation, and an associated blast tool are available at http://cantulab.github.io/data.
El duelo y cómo dar malas noticias en medicina
Authors: León-Amenero Deborah , Huarcaya-Victoria Jeff 
Published: March 2019

bien no todos los factores que generan un duelo patológico pueden ser controlados, el cómo se da la noticia de la pérdida a la persona es un factor importante, y, por lo tanto, necesario a tener en cuenta. El comunicar malas noticias es una tarea frecuente en el ámbito médico, pudiendo tener un impacto negativo tanto en los pacientes como en sus familiares si no se realiza de una forma adecuada. A pesar de su importancia, en diversos estudios se ha documentado que los estudiantes de medicina y los médicos no han recibido un entrenamiento formal para poder dar malas noticias. En este contexto el presente artículo busca brindarles a los médicos y estudiantes de medicina algunos conceptos precisos sobre estos temas para que puedan aplicarlo a su práctica clínica.
Producción científica asociada al gasto e inversión en investigación en universidades peruanas
Authors: Moquillaza-Alcántara Victor Hugo 
Published: March 2019

Introducción. La producción científica del Perú es baja en relación a otros países; se desconoce el impacto de la inversión en dicha producción a nivel nacional. Objetivo. Evaluar la asociación entre el gasto e inversión en investigación y la producción científica en temas de salud en universidades peruanas durante el año 2015. Métodos. Estudio observacional de análisis de fuentes secundarias del I Censo Nacional de Investigación y Desarrollo a Centros de Investigación del Consejo Nacional de Ciencia, Tecnología e Innovación Tecnológica (Concytec), de donde se seleccionó a las universidades peruanas y las publicaciones en el área de ciencias de la salud. Se evaluó la incidencia de riesgo relativo (IRR) crudo y ajustado para determinar el grado de asociación. Resultados. Existe una asociación significativa entre la producción científica y la remuneración a los docentes investigadores (IRR: 0,998; p<0,01), remuneración al personal de apoyo (IRR: 1,023; p<0,01), honorarios a consultores externos (IRR: 0,991; p<0,05), compra de otros servicios (IRR: 1,003; p<0,01) y la inversión en edificios (IRR: 0,998; p<0,01). Conclusiones. La remuneración a docentes investigadores, al personal de apoyo, a consultores externos, compra de otros servicios e inversión en edificios, se asocia a la mayor producción científica en temas de salud en las universidades peruanas.
El sobrepeso, la obesidad y la obesidad abdominal en la población adulta del Perú
Authors: Pajuelo Ramírez Jaime , Torres Aparcana Lizardo , Agüero Zamora Rosa , Bernui Leo Ivonne 
Published: March 2019

Introducción. La obesidad es un problema de salud pública; el objetivo del presente estudio fue determinar la prevalencia nacional y distribución del sobrepeso(S), obesidad(O) y obesidad abdominal (OA), en el Perú. Métodos. Se realizó un estudio observacional mediante el análisis de la Encuesta Nacional de Hogares 2012-2013 en el que se evaluaron a 20488 adultos. El diagnostico nutricional se determinó considerando el índice de masa corporal según la OMS: 18,5 a 24,9 normal, 25 a <30 sobrepeso, y ≥ a 30 kg/m2 obesidad. Asimismo, para la evaluación de OA se consideró la circunferencia de cintura ≥ 102 cm para varones y ≥ 88 cm para mujeres. Resultados. La prevalencia nacional de sobrepeso fue de 40,5% y de obesidad 19,7%, con un total de 60,2% de población adulta con exceso de peso. El 23,4% de O fueron mujeres y 15,7% varones; la OA en mujeres fue 51,2% y 14,8% en varones Los departamentos con mayor prevalencia de exceso de peso fueron Tacna (73,8%) e Ica (72,2%). Los departamentos con mayor prevalencia de OA fueron Lima, Ica y Lambayeque, con prevalencias superiores al 40%. Se presentó mayor prevalencia de O y OA en mayores de 40 años, en población que vive en la costa, a menos de 1000 msnm y que reside en áreas urbanas. Conclusiones. El 60,2% de población adulta peruana presentó exceso de peso (S y O), predominantemente en Tacna e Ica, incrementándose la prevalencia respecto a lo reportado previamente.
Užslėptas tapatybių konfliktas: LDK paveldo diskursai Lietuvos ir Baltarusijos interneto žiniasklaidoje 2013–2014 metais
Authors: Venckūnas Valius 
Published: March 2019

[full article and abstract in Lithuanian; abstract in English]
This article is aimed at presenting an insight into national identities as constructed on the basis of the heritage of the Grand Duchy of Lithuania (GDL) in the major Lithuanian and Belarusian news sites (2013–2014). By performing content analysis, it was revealed that in the vast majority of news publications, either Lithuania or Belarus, respectively by country of publishing, was considered as the main or only successor of the GDL, although this narrative was not elaborated upon and was seen as self-explanatory. The neighboring state was rarely criticized and its narrative mostly considered as frivolous and not worthy of attention. A lack of contact, discussion and mutual explanation between the Lithuanian and Belarusian narratives in the public sphere means that a conflict between both national identities can be seen as hidden or potential.
Online Media Ethics and the Privacy of Politicians in Kosovo
Authors: Jahiri Muhamet , Gërguri Dren 
Published: March 2019

[full article and abstract in English]
The pluralism of online media outlets, as well as the objective of these outlets to be the first to inform on events, may possibly lead these outlets to disrespect professional ethics. This paper will discuss the theoretical and ethical aspects of online media, its regulatory framework and particular cases when the respect of ethical standards when reporting on issues of privacy was potentially violated. This paper uses the purposive sampling method and comparative methods. The paper will examine a case study (where the intimate images of a politician were published), and whether ethical standards were respected in that particular case.The article reveals that in the context of information provision for a company, strategic and operational controlling are to be considered the most significant ones. Strategic controlling provides information on how to do the right activity, whereas operational controlling – on how an activity can be done right. The goals of a company can be achieved only through both of them. Tactical controlling is what connects strategic controlling to operational controlling; its paradigm can be expressed through two questions: 1) how to do the right activity right? 2) what should be done when a wrong activity is being done or the activity is being done wrongly? Information provision for the answers to these questions would ensure a direct relation and feedback of strategic and operational controlling. After analyzing the typologization of controlling based on its origin, it was identified that the two main schools of controlling practice exist that led to the development of two different models of controlling: the Anglo-Saxon (American) and European (German). An exemplary controlling model adapted for Lithuanian companies was prepared after comparing the American and German controlling models and evaluating them on the basis of the scope of tasks, dominant orientation, the role of the controller, and the information base. On the basis of this adapted model, an individual information provision controlling system can be created for any Lithuanian company. This article analyzes other types of controlling as well, evaluation of which is important when creating an efficient system for controlling information provision in a particular company.