bluuebunny/crossref_metadata_2025_split huggingface dataset:
Social work support and unmet social needs in life after stroke: a cross-sectional exploratory study
Authors: Lehnerer Sophie Mirabell , Hotter Benjamin , Padberg Inken , Knispel Petra , Remstedt Dike , Liebenau Andrea , Grittner Ulrike , Wellwood Ian , Meisel Andreas 
Published: June 2019

Abstract
Background:
Stroke patients are often affected by long-term disabilities with needs concerning social issues. There is relatively little consideration of social recovery of patients and the support required to return to work, receive social benefits, participate in daily life activities, maintain contact with family and friends and to organize financial affairs. In our study we aimed to investigate if existing tools record social needs adequately. We analyzed the current provision of social support provided in long-term care after stroke and whether unmet social needs were associated with quality of life, caregiver burden, overall function and degree of disability.

Methods:
Our analysis is part of the Managing Aftercare of Stroke study (MAS-I), a cross-sectional exploratory study of patient needs 2-3 years after initial stroke. Assessment tools included the Nikolaus-score (social situation), the EuroQoL (quality of life), the German Burden Scale for Family Caregivers (caregiver burden), the modified Rankin Scale (disability / dependence), Stroke Impact Scale (function and degree of disability) and the Stroke Survivor Needs Questionnaire (unmet needs).

Results:
Overall 57 patients were included in MAS-I, with ten patients classified in urgent need of socio-economic support according to the Nikolaus-score. Patients with lower than normal Nikolaus-score had a higher degree of disability. Thirty percent of all patients had never received professional social support. Social worker contact happened mostly during the stay in acute hospital or rehabilitation institution. Only four patients (11%) reported long-term support after discharge. Apart from social worker contact during acute care, 43% of patients had unmet needs in the long-term aftercare. Forty percent of all patients included in MAS-I were recommended for social work intervention after an in-depth analysis of their situation. Finally, we saw that unmet social needs were associated with lower quality of life and higher caregiver burden.

Conclusions:
Our data suggest significant unmet needs in social care in long-term stroke patients. Screening tools for unmet social needs such as the Nikolaus-score do not holistically report patients’ needs.
Metagenomic analysis of bile salt biotransformation in the human gut microbiome
Authors: Das Promi , Marcišauskas Simonas , Ji Boyang , Nielsen Jens 
Published: June 2019

Abstract
Background: In the biochemical milieu of human colon, bile acids act as signaling mediators between the host and its gut microbiota. Biotransformation of primary to secondary bile acids have been known to be involved in the immune regulation of human physiology. Several 16S amplicon-based studies with inflammatory bowel disease (IBD) subjects were found to have an association with the level of fecal bile acids. However, a detailed investigation of all the bile salt biotransformation genes in the gut microbiome of healthy and IBD subjects has not been performed.

Results: Here, we report a comprehensive analysis of the bile salt biotransformation genes and their distribution at the phyla level. Based on the analysis of shotgun metagenomes, we found that the IBD subjects harbored a significantly lower abundance of these genes compared to the healthy controls. Majority of these genes originated from Firmicutes in comparison to other phyla. From metabolomics data, we found that the IBD subjects were measured with a significantly low level of secondary bile acids and high levels of primary bile acids compared to that of the healthy controls.

Conclusions: Our bioinformatics-driven approach of identifying bile salt biotransformation genes predicts the bile salt biotransformation potential in the gut microbiota of IBD subjects. The functional level of dysbiosis likely contributes to the variation in the bile acid pool. This study sets the stage to envisage potential solutions to modulate the gut microbiome with the objective to restore the bile acid pool in the gut.
Use of Artra and Artra MSM Forte in osteoarthritis of the large joints and lowback pain
Authors: Sharapova E. P. , Alekseeva L. I. 
Published: June 2019

Knee and hip joint pain is the first and most common symptom that forces a patient to visit the doctor. Osteoarthritis (OA) treatment is aimed «primarily» at managing symptoms of the disease, i.e. reducing pain, improving the functional state of the joints, and finally at improving the patients’ quality of life. The Russian and international organizations have developed numerous guidelines for the treatment of OA, which include non-pharmacological and pharmacological methods, among which symptomatic slow-acting drugs are of special interest. These drugs are currently recommended to prescribe as the first-line drugs to treat OA. Analgesics and NSAIDs that rarely cause adverse effects, especially in older people and in patients with co-morbidities, who receive concomitant medications, are the most commonly prescribed medications for pain relief. This creates a problem when the drugs affect one another’s exposure and can limit the prescription of a range of drugs, which determines an increase in interest in other drugs called sustained-release symptomatic drugs, which are widely recognized in arthrology.The article presents the results of studies of Artra and Artra MSM Forte in patients with hip and knee OA, which were conducted in Russia.
Trihalomethane precursor reactivity changes in drinking water treatment unit processes during a storm event
Authors: Neil Chelsea W. , Zhao Yingying , Zhao Amy , Neal Jill , Meyer Maria , Yang Y. Jeffrey 
Published: June 2019

AbstractSource water quality can significantly impact the efficacy of water treatment unit processes and the formation of chlorinated and brominated trihalomethanes (THMs). Current water treatment plant performance models may not accurately capture how source water quality variations, such as organic matter variability, can impact treatment unit processes. To investigate these impacts, a field study was conducted wherein water samples were collected along the treatment train for 72 hours during a storm event. Systematic sampling and detailed analyses of water quality parameters, including non-purgeable organic carbon (NPOC), UV absorbance, and THM concentrations, as well as chlorine spiking experiments, reveal how the THM formation potential changes in response to treatment unit processes. Results show that the NPOC remaining after treatment has an increased reactivity towards forming THMs, and that brominated THMs form more readily than chlorinated counterparts in a competitive reaction. Thus both the reactivity and quantity of THM precursors must be considered to maintain compliance with drinking water standards, a finding that should be incorporated into the development of model-assisted treatment operation and optimization. Advanced granular activated carbon (GAC) treatment beyond conventional coagulation–flocculation–sedimentation processes may also be necessary to remove the surge loading of THM-formation precursors during a storm event.
Taxonomic and Functional Annotation of Termite Degraded Butea monosperma (Lam.) Kuntze (Flame of the Forest)
Authors: Kumar Ashwani , Vyas Preeti , Malla Muneer A. , Dubey Anamika 
Published: June 2019

Background:
Butea monosperma is an economically and medicinally important plant that grows all over India, however, the plant is highly susceptible to termite attack. The present study unravelled the bacterial community composition and their functional attributions from the termite degraded Butea.

Methods:
Total genomic DNA from termite degraded Butea monosperma samples was extracted and subjected to sequencing on Illumina's Miseq. The raw and unassembled reads obtained from high-throughput sequencing were used for taxonomic and functional profiling using different online and stand-alone softwares. Moreover, to ascertain the effect of different geographical locations and environmental factors, comparative analysis was performed using four other publically available metagenomes.

Results:
The higher abundance of Actinobacteria (21.27%), Proteobacteria (14.18%), Firmicutes (10.46%), and Bacteroidetes (4.11%) was found at the phylum level. The genus level was dominated by Bacillus (4.33%), Gemmatimonas (3.13%), Mycobacterium (1.82%), Acidimicrobium (1.69%), Thermoleophilum (1.23%), Nocardioides (1.44%), Terrimonas and Acidithermus (1.09%) and Clostridium (1.05%). Functional annotation of the termite degraded B. monosperma metagenome revealed a high abundance of ammonia oxidizers, sulfate reducers, dehalogenators, nitrate reducers, sulfide oxidizers, xylan degraders, nitrogen fixers and chitin degraders.

Conclusion:
The present study highlights the significance of the inherent microbiome of the degraded Butea shaping the microbial communities for effective degradation of biomass and different environmental toxicants. The unknown bacterial communities present in the sample can serve as enzyme sources for lignocelluloses degradation for biofuel production.
Job Satisfaction as a Mediator for the Influence of Transformational Leadership and Organizational Culture on Organizational Citizenship Behavior
Authors: Aldrin Neil , Yunanto Kuncono Teguh 
Published: June 2019

Background:
This study aims to explore the effect of transformational leadership and organizational culture on organizational citizenship behavior and see whether job satisfaction functions as a good mediator

Methods:
By using a quantitative approach, the data collection tool uses a psychological scale, the research respondents (N = 232) are employees and leaders of one company.

Results:
The results of the study show that job satisfaction functions as a mediator of the influence of transformational leadership and organizational culture on organizational citizenship behavior.

Conclusion:
By applying transformational leadership style accompanied by building a good organizational culture the organization has strong capital to foster employee organizational citizenship behaviour. This study also provides empirical evidence of the influence of these two variables on organizational citizenship behaviour through job satisfaction.
The Association Between Diabetes and Cognitive Function in Later Life
Authors: Momtaz Yadollah A. , Hamid Tengku A. , Bagat Mohamad F. , Hazrati Maryam 
Published: June 2019

Introduction:
Although diabetes through several possible mechanisms such as increased
microvascular pathology and inefficiency of glucose utilization during cognitive tasks can be associated
with cognitive impairment, there is inconclusive evidence that shows elderly diabetic patients
under therapy have higher cognitive function compared to their non-diabetics counterparts.
The present study was conducted to elucidate the association between diabetes and cognitive function
in later life.

Methods:
Data for this study, consisting of 2202 older adults aged 60 years and above, were taken
from a population-based survey entitled “Identifying Psychosocial and Identifying Economic Risk
Factor of Cognitive Impairment among Elderly. Data analysis was conducted using the IBM SPSS
Version 23.0.

Results:
The mean of MMSE was found to be 22.67 (SD = 4.93). The overall prevalence of selfreported
diabetes was found to be 23.6% (CI95%: 21.8% - 25.4%). The result of independent t-test
showed diabetic subjects had a higher mean score of MMSE (M = 23.05, SD =4 .55) than their
counterparts without diabetes (M = 22.55, SD = 5.04) (t = -2.13 p<.05). The results of multiple linear
regression analysis showed that diabetes was not significantly associated with cognitive function,
after controlling the possible confounding factors.

Conclusions:
The findings from the current study revealed that diabetes is not associated with cognitive
decline. This study supports the findings that long-term treatment of diabetes may reduce the
risk of cognitive decline. This finding may provide new opportunities for the prevention and management
of cognitive decline.
The Edinburgh Postnatal Depression Scale: Model Comparison of Factor Structure and its Psychosocial Correlates Among Mothers at One Month After Childbirth in Japan
Authors: Hada Ayako , Kubota Chika , Imura Masumi , Takauma Fumie , Tada Katsuhiko , Kitamura Toshinori 
Published: June 2019

Background:The Edinburgh Postnatal Depression Scale (EPDS; Cox, Holden & Sagovsky, 1987) has been widely used as a screening instrument. It is also used as a measure of Postnatal Depression (PND) severity. Various EPDS factor structure models have been proposed in many studies without an unequivocal conclusion. We compared first-order, higher-order factor, and bifactor models of the EPDS, and examined possible predictors of subscales by Structural Equation Modelling (SEM).Methods:Data came from a follow-up study of 758 women after childbirth on two occasions (five days and one month postnatal). We used the EPDS together with items tapping Negative Life Events (NLEs) and coping styles and behaviours.Results:The bifactor model showed the best fit with data compared with all other models: CFI = 0.999, RMSEA = 0.14, and AIC = 79.637. A single general dimension alongside three distinct subfactors (anhedonia, anxiety, and dysphoria) was predicted differentially by various predictor variables.Conclusion:Our study expanded on a previous factor structural study of the EPDS and developed the hierarchical (bifactor) model. The model’s construct validity was confirmed by its meaningful associations with NLEs and coping styles and behaviours.
Design of Reversible Shift Register Using Reduced Number of Logic Gates
Authors: Maity Heranmoy , Banerjee Sudipta , Biswas Arindam , Pal Anita , Bhattacharjee Anup Kumar 
Published: June 2019

Background:
Over the last few decades, reversible logic system/circuits have received considerable
attention in the diversified fields such as nanotechnology, quantum computing, cryptography,
optical computing and low power design of VLSI circuits due to their low power dissipation
characteristics.

Methods:
In this paper, we proposed the design of reversible shift register (SR) i.e. serial-in-serial out
(SISO), serial-in-parallel out (SIPO), parallel-in-serial out (PISO) and parallel-in-parallel out (PIPO)
SR using a reduced number of reversible logic gates and garbage output.

Results:
As compared to previously reported results, the improvement in our proposed model of SISO,
SIPO, PISO and PIPO was found to be 50 – 66.66 %, 42.85 – 66.66 %, 12.5 – 53.33 % and 50 –
66.66 % respectively, in terms of the number of reversible logic gates.
Amino Acid Profiles, Antimicrobial Activity and Anti-nutritional Contents of Two Wild Edible Plants (Sphenoclea zeylanica Gaertn. and Sphaerantus peguensis Kurz ex C.B. Clarke.)
Authors: Narzary Hwiyang , Basumatary Sanjay 
Published: June 2019

Background:The two wild plants viz. Sphenoclea zeylanica and Sphaerantus peguensis are seasonally consumed as vegetables by the Bodo people in Assam of North East India. Wild vegetables are considered as one of the cheapest sources for human nutrition that contains rich sources of numerous minerals and bioactive compounds which on consumption can contribute several health benefits against various diseases.Objective:The aim of the present study is to investigate amino acid profiles, antimicrobial property and anti-nutritional contents of the two wild edible plants.Methods:Amino acid profiles were determined by using ultra-performance liquid chromatography, antimicrobial activities of aqueous and methanol extracts of the plants were tested following the disc diffusion method against Bacillus cereus, Staphylococcus aureus, Proteus vulgaris and Escherichia coli, and anti-nutritional contents were evaluated based on the reported methods.Results:The total amino acid content found in S. zeylanica was 42.87 mg/g dry weight and it was found to be 32.65 mg/g dry weight in S. peguensis. The methanol extracts of the plants are exhibiting antibacterial activities against all the studied microorganisms. However, aqueous extracts showed no antibacterial activity against P. vulgaris and B. cereus. In this study, S. zeylanica species showed higher levels of anti-nutritional contents compared to S. peguensis.Conclusion:In the study, higher levels of essential amino acids were detected in S. zeylanica compared to S. peguensis. The methanol extracts of the plants showed more effective antimicrobial activities in comparison to the aqueous extracts and this may be due to the presence of antimicrobial compounds which are more readily soluble in methanol.
Self-medication of Ayurvedic Medicine Associated with Fatal Toxic Epidermal Necrolysis: A Case Report
Authors: Jangra Manjeet Singh , Chhabra Manik , Bhagavathula Akshaya Srikanth 
Published: June 2019

Introduction:
Ayurveda is one of the most renowned traditional systems of medicine
and is widely practiced in India. Self-medication of these ayurvedic medicines (AM’s)
may elicit more or less similar type of adverse reactions as synthetic drugs.

Methods:
We present a case report on toxic epidermal necrolysis due to self-medication of
ayurvedic medicine.

Case Report:
The present case is of a patient who used Singhnad Guggulu for 20 days and
developed Steven-Johnson Syndrome (SJS) followed by toxic epidermal necrolysis (TEN).
The patient was treated with steroids and antihistamines. The patient recovered completely
following seven days of treatment and discharged.

Results:
After ruling out the provisional diagnosis, the patient was diagnosed with druginduced
SJS/TEN. The World Health Organization-Uppsala Monitoring Center (WHOUMC)
causality assessment scale was used by taking into consideration the temporal relationship
and other relevant parameters and adverse drug reaction (ADR) was found to be
‘certain’.

Conclusion:
To our knowledge, the present case study is the first report of SJS/TEN that
was caused by “Singhnad Guggulu” suggesting clinicians to be vigilant about the possibility
of SJS/TEN occurrences with AM. Also, consumers should be advised to use these drugs
only on the prescription of the institutionally qualified ayurvedic practitioners.
GERAKAN DAKWAH SULTAN AGUNG (Arti Penting Perubahan Gelar Sultan Agung Terhadap Gerakan Dakwah di Jawa Pada Tahun 1613 M - 1645 M)
Authors: Hariyanto Hariyanto 
Published: June 2019

The peak of the glory of the Mataram kingdom occurred during the reign of Sultan Agung. He managed to perform da'wah movement to master Central Java, East Java and some areas in West Java. Many strategies of da'wah movement conducted by Sultan Agung. However, the change and the addition of the title by Sultan Agung is one thing that distinguishes the previous Mataram kings.
Sultan Agung recorded the changes and the addition of his title ranging from "Panembahan" to "Susuhunan" or "Sunan", to "Sultan" Degree "Susuhunan" or "Sunan" commonly used by the guardian gives charisma (authority) to the king. The title is used karen areas that have mastered the territory of the great Muslim Guardians. The title of "Sultan" which bears Sultan Agung further strengthens himself as a leader as well as a figure of Religion, who has responsibility towards his people and its creator .
Complexity of the title that carried the Sultan Agung able to raise its degree and bring social effects for the movement of his da'wah. Areas that did not initially recognize themselves as kings, managed to recognize themselves as kings and submit and obey the king's policies.
The complete title of Sultan Agung known as "Sultan Agung Hanyakrakusuma Senapati Ing Alaga Sayyidin Panatagama Khalifatullah" has the meaning that the third Mataram King is a leader who gets the mandate from Allah to organize the life of his people.
Keywords: Title, Sultan Agung, Movement of Da'wah
Predictors of using extracorporeal membrane oxygenation in lung transplantation
Authors: Khubutiya M. Sh. , Tarabrin E. A. , Zhuravel S. V. , Kotandzhyan V. G. , Karchevskaya N. A. , Pervakova E. I. , Danielyan Sh. N. , Kallagov T. E. , Saprin A. A. , Ibavov I. U. , Petukhova A. G. , Gasanov A. M. 
Published: June 2019

Rationale. Lung transplantation is the only definitive treatment in end-stage pulmonary disease. Extracorporeal membrane oxygenation (ECMO) has been used during surgery in recent years as a replacement for respiratory function; ECMO, however, has some drawbacks: the presence of an extracorporeal circuit, the need for heparinization, potential thrombogenicity that underlies the risks of developing specific complications that worsen the transplantation prognosis. In this regard, it is relevant to study the factors that make it possible to predict the need in intraoperative ECMO in order to avoid its unjustified use.Purpose. To identify predictors for intraoperative use of ECMO in lung transplantation.Material and methods. The medical records of patients who underwent lung transplantation in the Sklifosovsky Research Institute for Emergency Medicine from May 2011 to July 2017 were retrospectively reviewed. Forty nine bilateral lung transplantations were made where 15 patients (30.6%) had lung transplantation performed without ECMO, and 34 (69.4%) underwent lung transplantation and ECMO. A central veno-arterial connection was used in all patients. The study analyzed various factors of patient condition at baseline and identified the most significant of them that enabled to predict the need of ECMO use at surgery with a high degree of probability, avoiding episodes of gas exchange and hemodynamic impairments, the prolongation of surgery, and, therefore, the graft ischemia time.Results. As assessed in this study, pulmonary hypertension was the only predictor of an increased likelihood of using ECMO. The probability of connection to ECMO statistically significantly increased in the patients with systolic pulmonary artery pressure higher 50 mm Hg (p<0.05).Conclusion. The presence of pulmonary hypertension > 50 mm Hg determines the preventive use of ECMO during lung transplantation, which should reduce the number of uncontrolled emergencies during the main stages of surgical intervention; in all other cases, ECMO should be connected basing either on the pulmonary artery compression test results or when indicated.