bluuebunny/crossref_metadata_2025_split huggingface dataset:
Better Health‐Related Quality of Life in Systemic Lupus Erythematosus Predicted by Low Disease Activity State/Remission: Data From the Peruvian Almenara Lupus Cohort
Authors: Ugarte‐Gil Manuel F. , Gamboa‐Cárdenas Rocío V. , Reátegui‐Sokolova Cristina , Medina‐Chinchón Mariela , Zevallos Francisco , Elera‐Fitzcarrald Claudia , Pimentel‐Quiroz Victor , Cucho‐Venegas Jorge M. , Rodríguez‐Bellido Zoila , Pastor‐Asurza César A. , Alarcón Graciela S. , Perich‐Campos Risto 
Published: June 2019

ObjectiveTo determine if low disease activity state (LDAS)/remission predicts a better health‐related quality of life (HRQoL).MethodsPatients with systemic lupus erythematosus from a single center and having completed at least 2 visits were included. Visits were performed every 6 months. HRQoL was measured with the LupusQoL questionnaire. The definition of remission included a Systemic Lupus Erythematosus Disease Activity Index 2000 (SLEDAI‐2K) score of 0, prednisone daily dosage of ≤5 mg/day, and immunosuppressive drugs on maintenance dose. LDAS was defined as a SLEDAI‐2K score of ≤4, prednisone daily dosage of ≤7.5 mg/day, and immunosuppressive drugs as maintenance therapy. For these analyses, remission and LDAS were combined as one variable. Generalized estimating equations were calculated, using as the outcome 1 of each of the 8 components of the LupusQoL questionnaire in the subsequent visit and the activity state in the previous visit. Multivariable models were adjusted for possible confounders.ResultsA total of 243 patients were included. During the follow‐up, 590 visits (61.6%) were categorized as LDAS/remission. LDAS/remission predicted a better HRQoL in the components of physical health (B = 4.17 [95% confidence interval (95% CI) 1.20, 7.14]; P = 0.006), pain (B = 6.47 [95% CI 3.18, 9.76]; P < 0.001), planning (B = 4.97 [95% CI 1.43, 8.52]; P = 0.006), burden to others (B = 4.12 [95% CI 0.24, 8.01]; P = 0.037], emotional health (B = 4.50 [95% CI 1.56, 7.44]; P = 0.003), and fatigue (B = 3.25 [95% CI 0.04, 6.47]; P = 0.048).ConclusionBeing in LDAS/remission predicts a better HRQoL, especially in the components of physical health, pain, planning, burden to others, emotional health, and fatigue.
Elastic Properties of 2D Ultrathin Tungsten Nitride Crystals Grown by Chemical Vapor Deposition
Authors: Wang Hong , Sandoz‐Rosado Emil J. , Tsang Siu Hon , Lin Jinjun , Zhu Minmin , Mallick Govind , Liu Zheng , Teo Edwin Hang Tong 
Published: June 2019

Abstract3D transition metal nitrides are well recognized for their good electrical conductivity, superior mechanical properties, and high chemical stability. Recently, 2D transition metal nitrides have been successfully prepared in the form of nanosheets and show potential application in energy storage. However, the synthesis of highly crystalline and well‐shaped 2D nitrides layers is still in demand for the investigation of their intrinsic physical properties. The present paper reports the growth of ultrathin tungsten nitride crystals on SiO2/Si substrates by a salt‐assisted chemical vapor deposition method. High‐resolution transmission microscopy confirms the as‐grown samples are highly crystalline WN. The stiffness of ultrathin WN is investigated by atomic force microscopy–based nanoindentation with the film suspended on circular holes. The 3D Young's modulus of few‐layer (4.5 nm thick or more) WN is determined to be 3.9 × 102 ± 1.6 × 102 GPa, which is comparable with the best experimental reported values in the 2D family except graphene and hexagonal boron nitride. The synthesis approach presented in this paper offers the possibilities of producing and utilizing other highly crystalline 2D transition‐metal nitride crystals.
Systematic Control of the Orientation of Organic Phosphorescent Pt Complexes in Thin Films for Increased Optical Outcoupling
Authors: Kim Jongchan , Batagoda Thilini , Lee Jaesang , Sylvinson Daniel , Ding Kan , Saris Patrick J. G. , Kaipa Ushasree , Oswald Iain W. H. , Omary Mohammad A. , Thompson Mark E. , Forrest Stephen R. 
Published: June 2019

AbstractOrienting light‐emitting molecules relative to the substrate is an effective method to enhance the optical outcoupling of organic light‐emitting devices. Platinum(II) phosphorescent complexes enable facile control of the molecular alignment due to their planar structures. Here, the orientation of Pt(II) complexes during the growth of emissive layers is controlled by two different methods: modifying the molecular structure and using structural templating. Molecules whose structures are modified by adjusting the diketonate ligand of the Pt complex, dibenzo‐(f,h)quinoxaline Pt dipivaloylmethane, (dbx)Pt(dpm), show an ≈20% increased fraction of horizontally aligned transition dipole moments compared to (dbx)Pt(dpm) doped into a 4,4′‐bis(N‐carbazolyl)‐1,1′‐biphenyl, CBP, host. Alternatively, a template composed of highly ordered 3,4,9,10‐perylenetetracarboxylic dianhydride monolayers is predeposited to drive the alignment of a subsequently deposited emissive layer comprising (2,3,7,8,12,13,17,18‐octaethyl)‐21H,23H‐porphyrinplatinum(II) doped into triindolotriazine. This results in a 60% increase in horizontally aligned transition dipole moments compared to the film deposited in the absence of the template. The findings provide a systematic route for controlling molecular alignment during layer growth, and ultimately to increase the optical outcoupling in organic light‐emitting diodes.
Enantioselective Copper‐Catalyzed Three‐Component Carboboronation of Allenes: Access to Functionalized Dibenzo [b,f][1,4]oxazepine Derivatives
Authors: Deng Hao , Meng Ziwei , Wang Sifan , Zhang Zheming , Zhang Yaqi , Shangguan Yu , Yang Fazhou , Yuan Dekai , Guo Hongchao , Zhang Cheng 
Published: June 2019

AbstractA copper‐catalyzed enantioselective three‐component difunctionalization of allenes with seven‐membered cyclic imines and bis(pinacolato)diboron (B2(Pin)2) to approach functionalized dibenzo[b,f][1,4]oxazepine derivatives is developed. The chiral products are obtained in up to 81% yield, >20:1 dr, and 98% ee when either a chiral diphosphine ligand or a chiral ferrocenyl‐based P,N‐ligand is used. Furthermore, the reaction exhibits reversed diastereoselectivities when the chiral diphosphine ligand and the chiral P,N‐ligand are used respectively.magnified image
Merging Visible‐Light Photoredox and Organoamine Catalysis for the C‐3 Difluoroalkylation of Quinoxalin‐2(1H)‐Ones
Authors: Jin Can , Zhuang Xiaohui , Sun Bin , Li Deyu , Zhu Rui 
Published: June 2019

AbstractA mild and efficient protocol for visible‐light and organoamine cocatalyzed difluoroalkylation of quinoxalin‐2(1H)‐ones with functionalized difluoromethyl bromides has been developed. The transformation could be carried out at room temperature and gave a variety of C‐3 difluoroalkylated quinoxaline‐2(1H)‐ones in moderate to excellent yields. Moreover, mechanistic studies revealed that this transformation proceeded through a radical‐type debrominative coupling process with only need of catalytic amount of diisopropylethylamine (DIPEA). This strategy featured wide functional group tolerance, excellent regioselectivity, mild conditions, and operational simplicity.
Eye‐Readable Detection and Oxidation of CO with a Platinum‐Based Catalyst and a Binuclear Rhodium Complex
Authors: Qu Jiafu , Cao Yueqiang , Duan Xuezhi , Li Najun , Xu Qingfeng , Li Hua , He Jinghui , Chen Dongyun , Lu Jianmei 
Published: June 2019

AbstractToxic gases that are colorless and odorless, such as CO, are a major environmental concern and require early detection to prevent serious toxicological effects. In this study, a unique system (Pt/HMSs‐BRC) was fabricated by combining a catalyst (Pt/hollow mesoporous silica spheres, Pt/HMSs) with a silica gel containing an adsorbed chromogenic probe (binuclear rhodium complex, BRC). The process is a simple method to prepare well‐dispersed and uniform Pt nanoparticles. The Pt/HMSs‐BRC materials demonstrated early CO detection and excellent catalytic performance for CO oxidation. The probe exhibited remarkable color modulation from gray‐violet to light‐yellow when exposed to CO concentration levels above 50 ppm, and the color of the chromogenic probe was fully recoverable. By a kinetics‐assisted discrimination method and DFT calculations, it was found that the corner Pt sites are the dominant active sites for CO oxidation.
Dimension‐Matched Zinc Phthalocyanine/BiVO4 Ultrathin Nanocomposites for CO2 Reduction as Efficient Wide‐Visible‐Light‐Driven Photocatalysts via a Cascade Charge Transfer
Authors: Bian Ji , Feng Jiannan , Zhang Ziqing , Li Zhijun , Zhang Yuhang , Liu Yadi , Ali Sharafat , Qu Yang , Bai Linlu , Xie Jijia , Tang Dongyan , Li Xin , Bai Fuquan , Tang Junwang , Jing Liqiang 
Published: June 2019

AbstractCascade charge transfer was realized by a H‐bond linked zinc phthalocyanine/BiVO4 nanosheet (ZnPc/BVNS) composite, which subsequently works as an efficient wide‐visible‐light‐driven photocatalyst for converting CO2 into CO and CH4, as shown by product analysis and 13C isotopic measurement. The optimized ZnPc/BVNS nanocomposite exhibits a ca. 16‐fold enhancement in the quantum efficiency compared with the reported BiVO4 nanoparticles at the excitation of 520 nm with an assistance of 660 nm photons. Experimental and theoretical results show the exceptional activities are attributed to the rapid charge separation by a cascade Z‐scheme charge transfer mechanism formed by the dimension‐matched ultrathin (ca. 8 nm) heterojunction nanostructure. The central Zn2+ in ZnPc could accept the excited electrons from the ligand and then provide a catalytic function for CO2 reduction. This Z‐scheme is also feasible for other MPc, such as FePc and CoPc, together with BVNS.
Bis(1,3‐dithiol‐2‐ylidene)‐Substituted Subtriazachlorin: A Subphthalocyanine Analogue with Redox Properties
Authors: Wang Yemei , Mori Shigeki , Furuta Hiroyuki , Shimizu Soji 
Published: June 2019

AbstractBis(1,3‐dithiol‐2‐ylidene)‐substituted subtriazachlorin was formed because of an unusual reaction of a 1,3‐dithiole‐2‐one‐fused subphthalocyanine in a triethylphosphite‐mediated tetrathiafulvalene synthesis. In this novel molecule, the bis(1,3‐dithiol‐2‐ylidene)ethane moiety and subtriazachlorin structure are fused, resulting in an electron‐donating ability and broad absorption in the near‐infrared region.
High oxygen permeable Zeolite‐4A poly(dimethylsiloxane) membrane for air separation
Authors: Prajapati Pradeep K. , Kansara Ankit M. , Aswal Vinod K. , Singh Puyam S. 
Published: June 2019

ABSTRACTHigh oxygen permeability with optimal selectivity of the membrane is required for advancement in air separation membrane technology. Zeolite 4A‐PDMS composite membranes were prepared by incorporation of Zeolite 4A nanoscale crystals during the polymerization process of PDMS membrane using toluene andn‐heptane solvents, and their oxygen gas permeability and selectivity were explored. Small angle neutron scattering (SANS) technique was further used to study the polymer chain conformation and structure of membranes influenced by Zeolite 4A loading. The intersegmental distance between polymer chains and polymer chain aggregation or clustering were found to be increased on increasing the Zeolite 4A content in the membranes. Increment in the O2permeability and O2/N2selectivity were observed for both type of membranes (toluene andn‐heptane) with 1 wt% Zeolite 4A loading. The best performance result with O2/N2selectivity of 2.6, and O2permeability of 1052 Barrer was exhibited by PDMS/toluene membrane loaded with 1 wt% Zeolite 4A. The PDMS/toluene membranes with 10 wt% Zeolite 4A loading exhibited increased O2permeability of 1245 Barrer with a fair O2/N2selectivity of ~1.7, while the PDMS/n‐heptane membrane with the same loading exhibited excellent O2permeability of 6773 Barrer but lesser O2/N2selectivity of ~1.2. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci.2019,136, 48047.
Bioenergy production using Trichormus variabilis – a review
Authors: Abedi Sepideh , Astaraei Fatemeh R. , Ghobadian Barat , Tavakoli Omid , Jalili Hassan , Chivasa Stephen , Greenwell Hugh Christopher 
Published: June 2019

AbstractFossil‐fuel processing and consumption contaminates air, soil, and water resources through the release of hazardous chemicals. The harnessing of renewable energy resources and development of sustainable technologies have become prime targets of research and increased investment to protect the environment. The use of bio‐based feedstocks in energy production provides a valuable pollution‐curbing pathway with sustainability credentials, especially when wastewater is used to provide the nutrient requirements. The filamentous cyanobacterium Trichormus variabilis has attracted substantial attention from researchers due to its potential for dual industrial functions in bioenergy production and bioremediation. This species can use the power of sunlight energy efficiently to fix atmospheric CO2 and to generate valuable chemical compounds, such as carbohydrates and fatty acids, which can be converted to biofuels. As it grows in nutrient‐rich wastewater (industrial effluent) it can serve as a bio‐absorbant and replace costly chemical catalysts and nano‐materials traditionally used for the removal of nutrients and metals. However, no recent review has presented the potential for state‐of‐the‐art T. variabilis‐driven phycoremediation‐bioenergy production systems. This review suggests possible routes from phycoremediation to energy production as a strategy for developing the industrial application of T. variabilis. It brings important research results on this species together and highlights major related challenges and opportunities. It explores the current status of the use of algae in bioremediation and the production of liquid and gaseous fuels utilizing wild‐type and mutants of T. variabilis. Finally, key points underlying the potential for future research on optimization of robust technologies for supplying sustainable bioenergy using this organism are presented. © 2019 Society of Chemical Industry and John Wiley & Sons, Ltd
Genetic association analysis of 5‐HTR2A gene variants in eating disorders in a Mexican population
Authors: Genis‐Mendoza Alma Delia , Ruiz‐Ramos David , López‐Narvaez María Lilia , Tovilla‐Zárate Carlos Alfonso , Rosa García Ana , Cortes Meda Gabriela , Martinez‐Magaña José Jaime , González‐Castro Thelma Beatriz , Juárez‐Rojop Isela Esther , Nicolini Humberto 
Published: June 2019

AbstractIntroductionThe 5‐HTR2A gene has been implicated as candidate gene for eating disorders. The aim of the present study was to analyze the association of rs6311 and rs6313 polymorphisms of 5‐HTR2A gene with eating disorders in Mexican population, and to evaluate if the polymorphisms of 5‐HTR2A gene were associated with comorbidities in eating behavior.MethodsWe conducted a case–control analysis with 460 subjects. We included 168 patients with eating disorders and 292 controls; two polymorphisms of 5‐HTR2A gene were genotyped. We assessed the association by allele, genotype, and inheritance models. Psychiatric comorbidities were analyzed by genotype in patients with eating disorders.ResultsWe found an association between rs6311 and eating disorders in a Mexican population by allele (OR = 8.09; 95% CI = 5.99–11.03; p = 2.2e‐16) and genotype (OR = 76.14; 95% CI = 35.61–177.18; p = 2.2e‐16). Individuals who carried GG genotype showed increased risk for suicide attempted (OR = 2.14; CI = 1.10–4.26; p = 0.035) as comorbidity associated with eating disorders. No positive associations were observed for rs6313 polymorphism.ConclusionOur results showed an association of rs6311 (A1438G) polymorphism of 5‐HTR2A gene with eating disorders, and these polymorphic variants could increase the risk of psychiatric comorbidities. However, more studies are required to replicate the results and to reach to a conclusive association between eating disorders and rs6311.
Plasma Brain‐Derived Neurotrophic Factor (BDNF) and serum cortisol levels in a sample of workers exposed to occupational stress and suffering from Adjustment Disorders
Authors: Buselli Rodolfo , Veltri Antonello , Baldanzi Sigrid , Marino Riccardo , Bonotti Alessandra , Chiumiento Martina , Girardi Michelle , Pellegrini Luca , Guglielmi Giovanni , Dell'Osso Liliana , Cristaudo Alfonso 
Published: June 2019

AbstractIntroductionDecreased plasma BDNF (pBDNF) levels have been proposed as a biomarker in illness phases of mood disorders. Serum cortisol (seC) levels are an index of energy mobilization and stress. The aim of this cross‐sectional study was to evaluate pBDNF and seC levels in workers exposed to occupational stress and suffering from Adjustment Disorders (AD) compared to healthy workers.MethodsPlasma BDNF and seC levels were measured by means of specific immunoassays in 64 AD patients and 38 healthy controls. Perceived and occupational stress was evaluated in patients and controls using the Psychological Stress Measure (PSM) and the Job Content Questionnaire (JCQ). Psychopatological symptoms in patients were assessed using specific rating scales.ResultsPlasma BDNF levels resulted significantly higher in patients than in controls, whereas no significant differences were found for seC levels. In patients but not in controls pBDNF levels showed a significant positive correlation with seC levels. Perceived stress levels were positively correlated with all psychopatological rating scales scores.ConclusionsBDNF could play a key role in the pathophysiology of stress‐related disorders and its peripheral levels elevation could contribute to protect neurons under stress. Further research is needed focusing on biomarkers for stress‐related disorders as a potential tool for the diagnosis and prevention of occupational diseases.
Comprehensive genomic profiling of small cell lung cancer in Chinese patients and the implications for therapeutic potential
Authors: Hu Jing , Wang Yu , Zhang Yuan , Yu Yanfei , Chen Hui , Liu Kuai , Yao Ming , Wang Kai , Gu Weiguang , Shou Tao 
Published: June 2019

AbstractBackgroundSmall cell lung cancer (SCLC) is one of the deadliest malignancies and accounts for nearly 15% of lung cancers. Previous study had revealed the genomic characterization of SCLC in Western patients. However, little is known about that in Chinese SCLC patients.MethodsFormalin‐fixed paraffin‐embedded tumor tissues and matched blood samples from 122 Chinese SCLC patients were collected for next generation sequencing to detect 450 cancer‐related genes. All pathological diagnoses were confirmed by independent pathologists.ResultsThe most frequently altered genes were TP53 (93.4%), RB1 (78.7%), LRP1B (18.9%), KMT2D (15.6%), FAT1 (11.5%), KMT2C (11.5%), SPTA1 (11.5%), STK24 (11.5%), FAM135B (10.7%), and NOTCH1 (10.7%). The gene fusion/rearrangement detection rate was 16.4%, and mostly occurred in chromosomes 7 and 17. The rate of co‐occurring mutations of TP53 and RB1 in these Chinese SCLC patients was 74.6%, and lower than the reported Western patients (90.9%, P = 0.007). The most common gene mutations (83.6%) were found in cell cycle signaling pathway in Chinese SCLC patients. Mutation of Wnt and Notch signaling pathways in the Chinese cohort were lower than Western cohort (P = 0.0013 and 0.0068). A significant association was found between high tumor mutation burden and mutations involved in FAT1, TP53, SPTA1, KEAP1, KMT2D, MAGI2, NOTCH2, NOTCH3, FLT1, KDM6A, and FAT4.ConclusionsIn this study, we characterized the genomic alterations profile of Chinese SCLC patients. Compared with westerners, the genetic alterations of Chinese SCLC patients presented different patterns. Our data might provide useful information in targeted therapy and drug development for Chinese SCLC patients.
Patent ductus venosus in an infant with direct hyperbilirubinemia
Authors: Kamali Leila , Moradi Maryam , Ebrahimian Shadi , Masjedi Esfahani Mahsa , Jafarpishe Mohamad Saleh 
Published: June 2019

AbstractPatent ductus venosus is caused by a defect in obliteration of ductus venosus after birth. Ductus venosus connects umbilical vein and inferior vena cava during fetal period. Patent ductus venosus is a very rare cause of cholestatic jaundice.
A Sterically Overcrowded, Isopropyl‐Substituted, Lanthanide‐Chelating Tag for Protein Pseudocontact Shift NMR Spectroscopy: Synthesis of its Macrocyclic Scaffold and Benchmarking on Ubiquitin S57 C and hCA II S166 C
Authors: Joss Daniel , Bertrams Maria‐Sophie , Häussinger Daniel 
Published: June 2019

AbstractA sterically overcrowded lanthanide‐chelating tag has been synthesized in order to investigate the influence on the obtained pseudocontact shifts and the anisotropic part of the magnetic susceptibility tensor compared to those of its predecessor DOTA‐M8‐(4R,4S)‐SSPy. For the first time, a concise synthetic route is presented for isopropyl‐substituted cyclen, the macrocyclic scaffold of the lanthanide‐chelating tag, delivering the macrocycle in an overall yield of 6 % over 11 steps. The geometry of the lutetium complex has been assigned by ROESY experiments, adopting exclusively a Λ(δδδδ) conformation, and DFT calculations have confirmed a stabilization of 32.6 kJ mol−1 compared to the Δ(δδδδ) conformer. The highly rigidified lanthanide‐chelating tag induces strong pseudocontact shifts of up to 6.5 ppm on ubiquitin S57 C, shows significantly improved tensor properties compared to those of its predecessor, and constitutes a highly promising starting point for the further development of lanthanide‐chelating tags.
Scandium Phosphonioketene: Synthesis, Bonding and Reactivity
Authors: Mao Weiqing , Wang Yaya , Xiang Li , Peng Qian , Leng Xuebing , Chen Yaofeng 
Published: June 2019

AbstractReaction of a scandium phosphoniomethylidene with carbon monoxide provides the first scandium phosphonioketene (1). X‐ray diffraction analysis shows that the complex has a very short Sc−C bond (2.138(2) Å), and DFT calculations indicate that this unusual short bond length is due to the significant contribution of ionic coulomb interaction between carbon and scandium and the η2‐O,C coordination fashion. Complex 1 is thermally stable, albeit shows high reactivity towards a series of unsaturated substrates, including carbon dioxide, ketone, imine, nitrile and isocyanide. In the reaction with tert‐butyl isocyanide, not only an insertion of tert‐butyl isocyanide into the Sc−C bond occur, but also a C−H activation on the phenyl ring. DFT calculations show that the reactivity of 1 operated by nucleophilic properties, and therefore the reaction mechanism favors the nucleophilic attack to isocyanide as a rate‐determining step, followed by the stepwise C−H activation through an interesting C−H deprotonation.
Prediction of the Impact of Cytochrome P450 2C9 Genotypes on the Drug–Drug Interaction Potential of Siponimod With Physiologically‐Based Pharmacokinetic Modeling: A Comprehensive Approach for Drug Label Recommendations
Authors: Huth Felix , Gardin Anne , Umehara Kenichi , He Handan 
Published: June 2019

We predicted the drug–drug interaction (DDI) potential of siponimod in presence of cytochrome P450 (CYP)2C9/CYP3A4 inhibitors/inducers in subjects with different CYP2C9 genotypes by physiologically‐based pharmacokinetic (PK) modeling. The model was established using in vitro and clinical PK data and verified by adequately predicting siponimod PK when coadministered with rifampin. With strong and moderate CYP3A4 inhibitors, an increased DDI risk for siponimod was predicted for CYP2C9*3/*3 genotype vs. other genotypes area under the curve ratio (AUCR): 3.03–4.20 vs. ≤ 1.49 for strong; 2.42 vs. 1.14–1.30 for moderate. AUCRs increased with moderate (2.13–2.49) and weak (1.12–1.42) CYP3A4/CYP2C9 inhibitors to the same extent for all genotypes. With strong CYP3A4/moderate CYP2C9 inducers and moderate CYP3A4 inducers, predicted AUCRs were 0.21–0.32 and 0.35–0.71, respectively. This complementary analysis to the clinical PK‐DDI studies confirmed the relevant influence of CYP2C9 polymorphism on the DDI behavior of siponimod and represented the basis for the DDI labeling recommendations.