bluuebunny/crossref_metadata_2025_split huggingface dataset:
Lean project planning and control: empirical investigation of ETO projects
Authors: Jünge Gabriele Hofinger , Alfnes Erlend , Kjersem Kristina , Andersen Bjorn 
Published: April 2019

PurposeThe purpose of this paper is to empirically investigate an effective project management practice focusing on planning and control. By doing so, it contributes to the debate on rethinking traditional project management practices and accentuates the need for adjustments based on the project context.Design/methodology/approachThis paper extends the project management theory by proposing a lean project planning (LPP) and control framework, developed and tested in collaboration with ten engineer-to-order (ETO) companies. By following a design science research approach, elements from lean thinking and current project planning and control practices are combined into a maturity model (MM).FindingsETO project characteristics are identified, and their implications for planning and control are discussed. Nine enablers that transform current project planning and control approaches into a lean approach are defined, allowing the analysis of the underlying complexity of planning and controlling ETO projects and thus facilitating the determination of the actions required to improve project performance.Research limitations/implicationsOnce fully embedded in an organization, the presented MM can provide a safe framework for self-criticism and can be used to conduct self-assessments without the need for an external facilitator. Thus, this paper is of particular interest to practicing project managers who aim to implement LPP and control.Originality/valueTo the authors’ best knowledge, this paper is the first to empirically examine the journey toward LPP and control from a MM perspective. This research attempts to describe the enablers of LPP and control.
Pemphigus‐like hypereosinophilic syndrome with FIP1L1–PDGFRA fusion gene: A challenging and uncommon clinical presentation
Authors: Curto‐Barredo Laia , Segura Sonia , Ishii Norito , Hashimoto Takashi , Mascaró José M. , Espinet Blanca , Besses Carles , Pujol Ramon M. 
Published: April 2019

AbstractHypereosinophilic syndrome (HES) is often associated with cutaneous manifestations, mostly pruritic lesions, urticaria and angioedema. Mucosal lesions are rarely seen in HES but, when present, are usually the first manifestation of the disease. The clinical presentation may be heterogeneous, including erosions, aphthae or ulcers, and can be easily confused with other mucocutaneous disorders. Here, we present the case of a 64‐year‐old man with severe chronic erosive oral mucositis simulating pemphigus in which the finding of persistent eosinophilia and elevation of B12 vitamin serum levels raised the suspicion of HES. The FIP1L1–PDGFRA fusion gene (4q12) was detected by fluorescence in situ hybridization and the patient was treated with imatinib mesylate with complete response of the disease.
Time‐frequency analysis based on curvelet transforms with time skewing
Authors: Wang Jiao , Li Zhenchun , Gross Lutz , Tyson Stephen 
Published: April 2019

ABSTRACTOil and gas exploration gradually changes to the deep and complex areas. The quality of seismic data restricts the effective application of conventional time‐frequency analysis technology, especially in the case of low signal‐to‐noise ratio. To address this problem, we propose a curvelet‐based time‐frequency analysis method, which is suitable for seismic data, and takes into account the lateral variation of seismic data. We first construct a kind of curvelet adapted to seismic data. By adjusting the rotation mode of the curvelet in the form of time skewing, the scale parameter can be directly related to the frequency of the seismic data. Therefore, the curvelet coefficients at different scales can reflect the time‐frequency information of the seismic data. Then, the curvelet coefficients, which represent the dominant azimuthal pattern, are converted to the time‐frequency domain. Since the curvelet transform is a kind of sparse representation for the signal, the screening process of the dominant coefficient masks most of the random noise, which enables the method to adapt for the low signal‐to‐noise ratio data. Results of synthetic and field data experiments using the proposed method demonstrate that it is a good approach to identify weak signals from strong noise in the time‐frequency domain.
The role of trust in joined‐up government activities: Experiences from Health in All Policies in South Australia
Authors: Delany‐Crowe Toni , Popay Jennie , Lawless Angela , Baum Fran , MacDougall Colin , van Eyk Helen , Williams Carmel 
Published: April 2019

AbstractTrust has been consistently identified as an important enabling factor for joined‐up government activity to generate strong, integrated and effective social policy. Despite this, there has been comparatively little detailed analysis of the complexities and dynamics involved. This paper provides a detailed examination of how trust is built, nurtured and, in some instances, lost during joined‐up policy activity. It draws on interview and survey data that reveal the dynamics of relationships formed under the South Australian Health in All Policies initiative. The research extends the parameters of organisational analyses of trust. Previous typologies are mostly descriptive, with limited explanatory power, typically focusing on individuals and institutions separately rather than integrating these foci to consider how trust operates within whole systems. By integrating Giddens’ theoretical perspectives on trust with existing typologies, the paper generates understanding about how trust operates as a resource within non‐traditional joined‐up government working relationships, serving to bridge the gap between the known and unknown, and acting as a productive resource to stimulate action within government systems that are perceived to feature high levels of risk. A model is provided to explain the interrelated dynamics of trust building, maintenance, monitoring and repair.
Renoprotective effects of brown adipose tissue activation in diabetic mice
Authors: Cai Ying‐Ying , Zhang Hong‐Bin , Fan Cun‐Xia , Zeng Yan‐Mei , Zou Shao‐Zhou , Wu Chun‐Yan , Wang Ling , Fang Shu , Li Ping , Xue Yao‐Ming , Guan Mei‐Ping 
Published: April 2019

AbstractBackgroundBrown adipose tissue (BAT) has been regarded as a potential target organ to combat obesity and related metabolic disorders. However, the effect of BAT activation on the development of diabetic kidney disease (DKD) remains unclear.MethodsDiabetic mice were induced by streptozotocin (STZ) combined with a high‐fat diet. To activate BAT, mice were administered 1 mg/kg per day, i.p., CL316,243, a β3‐adrenergic receptor agonist, for 4 weeks. Blood glucose, serum lipids, adipokines, 24‐hour urinary albumin, 8‐hydroxydeoxyguanosine (8‐OHdG), and circulating microRNA (miRNA) levels were analyzed, in addition to renal pathology. Histological changes (fibrosis, inflammation) were evaluated in the kidneys, as was the expression of oxidative stress‐related genes. Renal signaling pathways (fibroblast growth factor [Fgf]21/β‐klotho/FGF receptor 1c and AMP‐activated protein kinase[AMPK]/sirtuin 1 [Sirt1]/peroxisome proliferator‐activated receptor‐γ coactivator‐1α [Pgc1α]) were also evaluated.ResultsCompared with untreated STZ‐diabetic mice, CL316,243 treatment reduced blood glucose, albeit not significantly (20.58 ± 3.55 vs 23.60 ± 3.90 mM), and significantly decreased triglycerides and low‐density lipoprotein cholesterol and increased high‐density lipoprotein cholesterol. Simultaneously, BAT activation significantly decreased 24‐hour urinary albumin (34.21 ± 6.28 vs 70.46 ± 15.81 μg/24 h; P < 0.05) and 8‐OHdG, improved renal fibrosis, inflammation, and oxidative stress, and ameliorated renal morphological abnormalities. In addition to enhancing BAT activity, CL316,243 significantly increased serum adiponectin concentrations and renal Fgf21 sensitivity, and reactivated the renal AMPK/Sirt1/Pgc1α signaling pathway. Furthermore, CL316,243 treatment increased levels of some circulating miRNAs and downregulated expression of their target genes in the kidney.ConclusionsActivating BAT could improve kidney injury in diabetic mice via metabolic improvements and renal AMPK activation by beneficial adipokines and miRNAs.
Lu177‐PSMA therapy for men with advanced prostate cancer: Initial 18 months experience at a single Australian tertiary institution
Authors: McBean Rhiannon , O'Kane Brooke , Parsons Rex , Wong David 
Published: April 2019

AbstractIntroductionLutetium‐177‐PSMA (LuPSMA) is a targeted systemic radioligand treatment for metastatic castration‐resistant prostate cancer (mCRPC). LuPSMA is considered as an experimental treatment not yet used in routine practice. Here, we report our experience following the introduction of LuPSMA therapy at our institution.MethodsReferred mCRPC patients were assessed for treatment suitability including Gallium‐68‐PSMA PET/CT and blood tests. Suitable patients underwent up to four cycles of LuPSMA treatment. Response to treatment was assessed by changes in serum prostate‐specific antigen (PSA) levels. Toxicity was assessed by recording of adverse events.ResultsIn an 18 month period, 50 patients underwent 132 cycles of LuPSMA therapy. Patients underwent a median of three cycles each (range: 1–4) and the mean administered amount of activity per cycle was 5.9 GBq (range: 3.5–8.2 GBq). PSA decline could be calculated for 49 patients, with a best PSA decline of ≥ 50% observed in 22 patients (44.9%). Adverse events were reported across 45 of 132 LuPSMA cycles. Most adverse events were grade I (42/45) and the remaining three events were grade II.ConclusionInitial experience at our site supports the use of LuPSMA as an emerging safe and effective treatment for mCRPC. Since introducing LuPSMA therapy at our institution, 44.9% of patients have experienced a decline in PSA level ≥ 50% with low or minimal toxicity. This is an important finding as these patients had previously exhausted all available treatment options. Overall, we have found patients and their primary care doctors have eagerly accepted LuPSMA as another line of defence against mCRPC.
Time efficiency and quality of outcomes in a model‐free digital workflow using digital impression immediately after implant placement: A double‐blind self‐controlled clinical trial
Authors: Pan Shaoxia , Guo Danni , Zhou Yongsheng , Jung Ronald E. , Hämmerle Christoph H. F. , Mühlemann Sven 
Published: April 2019

AbstractObjectiveTo assess the clinical and laboratory time efficiency and quality of outcomes for posterior single implant crowns by means of a model‐free digital workflow using digital impressions immediately after implant placement.MethodsForty patients missing a single posterior tooth received implant therapy. For within‐subject comparison, digital impressions were taken immediately after implant placement and conventional impressions after implant healing. Two monolithic zirconia crowns were fabricated using a laboratory‐based CAD‐CAM system. One crown was produced from the immediate digital impression and a model‐free digital workflow (test group), and the second crown was produced from the conventional impression and a hybrid workflow (control group). Clinical and laboratory time was recorded. Quality of outcomes was evaluated double‐blinded. A paired‐sample t test was applied for statistical analysis.ResultsThe total mean chairside time (impression and delivery) was 23.2 min (95%CI 22.2, 24.3) in the test group and 25.7 min (95%CI 24.4, 26.9) in the control group (p = 0.013). Significantly less laboratory time was needed in the model‐free digital workflow (13.6 min, 95%CI 11.5, 15.6) as compared to the model‐based hybrid workflow (29.9 min, 95%CI 25.7, 34.2) (p < 0.05). At crown delivery, 4/40 (test) and 12/40 (control) had no need of chairside adjustments, and 6/40 (test) and 5/40 (control) implant crowns were in need of additional laboratory interventions.ConclusionThe fabrication of posterior single implant crowns using digital impressions taken immediately after implant placement and a model‐free, laboratory‐based digital workflow was more time efficient and resulted in similar quality of outcomes as a hybrid workflow using conventional impressions.
Depletion of primary cilium in acral melanoma
Authors: Love Nick R. , Lang Ursula E. , Cheung Christine , Kim Jinah 
Published: April 2019

AbstractBackgroundA eukaryotic cell's primary cilium (PC) is critical for cell signaling, migration and homeostasis. Primary cilium dysfunction has been demonstrated in several malignancies, but whether primary cilia loss occurs in acral melanoma has remained unknown. To address this, we examined the ciliation index (% melanocytes containing a PC) of patient‐derived, biopsy‐proven acral melanoma and compared these to benign acral nevi.MethodsWe generated a pilot initiative study that included six acral melanomas and seven acral nevi derived from the foot. Using fluorescent immunohistochemistry, we calculated ciliation indexes of Sox10+ melanocytes.ResultsAverage ciliation index for acral nevi was 74.0% (SE of the mean [SEM] 3.3%) vs 9.3% for acral melanoma (SEM 5.7%), finding a statistically significant difference between the groups (P‐value <.001, two tailed t test).ConclusionThe data show a significant loss of primary cilia in malignant acral melanoma vs benign acral nevi, suggesting that cilia may play an important role during acral melanoma formation. Our data, which should be validated by a larger study with longer follow‐up period, suggest that examining ciliation index may be a useful diagnostic test when distinguishing benign acral nevi from melanoma.
‘No Smoke without Fire’: Citizenship and Securing Economic Enclaves in Mozambique
Authors: Buur Lars , Sumich Jason 
Published: April 2019

ABSTRACTThis article explores the complicated interrelationship between economic enclaves, their associated security practices and the formation of national citizens in Mozambique. From the colonial era of company rule to the large‐scale foreign direct investments of the present day, investors have feared the destructive fires of rampant ‘mobs’, unruly workers and the potentially rebellious populace more generally. Signs of smoke point to trouble for investors, who can draw on complex security arrangements, including corporate social responsibility programmes, unions, private security companies, community leaders, state police and specialized state and rapid response units with the latest communications and transport technologies, to try to protect their investments from labour unrest and political demands. Through a variety of ethnographic materials on mega‐investments in the sugar industry over the last two decades, the article explores the centrality of complex security arrangements to strategies of governance that use such arrangements in an attempt to produce disciplined national subjects.
Single introductions of soil biota and plants generate long‐term legacies in soil and plant community assembly
Authors: Wubs E. R. Jasper , van der Putten Wim H. , Mortimer Simon R. , Korthals Gerard W. , Duyts Henk , Wagenaar Roel , Bezemer T. Martijn 
Published: April 2019

AbstractRecent demonstrations of the role of plant–soil biota interactions have challenged the conventional view that vegetation changes are mainly driven by changing abiotic conditions. However, while this concept has been validated under natural conditions, our understanding of the long‐term consequences of plant–soil interactions for above‐belowground community assembly is restricted to mathematical and conceptual model projections. Here, we demonstrate experimentally that one‐time additions of soil biota and plant seeds alter soil‐borne nematode and plant community composition in semi‐natural grassland for 20 years. Over time, aboveground and belowground community composition became increasingly correlated, suggesting an increasing connectedness of soil biota and plants. We conclude that the initial composition of not only plant communities, but also soil communities has a long‐lasting impact on the trajectory of community assembly.
Network change in the ipsilesional cerebellum is correlated with motor recovery following unilateral pontine infarction
Authors: Liu G. , Tan S. , Peng K. , Dang C. , Xing S. , Xie C. , Zeng J. 
Published: April 2019

Background and purposePatients with acute pontine infarcts generally have good short‐term motor outcomes; however, the mechanisms underlying this recovery of function remain unclear.MethodsTwenty well‐recovered patients with acute pontine infarcts and 20 well‐recovered patients with acute striato‐capsular infarcts were recruited. Fugl‐Meyer assessment and resting‐state functional magnetic resonance imaging were performed 1, 4 and 12 weeks after onset. Patients were further assigned to better and worse recovery subgroups according to the degree of motor recovery at the twelfth week after stroke. Voxel‐wise degree centrality (DC)–behavior correlation analysis was used to identify brain regions related to changes in motor function within 12 weeks after stroke.ResultsA significant correlation was found between DC and Fugl‐Meyer scores within 12 weeks in the ipsilesional cerebellar crus I and crus II in patients with pontine infarction and in the ipsilesional middle temporal gyrus in patients with striato‐capsular infarction (all P < 0.001, AlphaSim corrected). The mean DC in these areas was higher both in the better and worse recovery subgroups at the fourth than at the first week (all P < 0.05). In addition, the mean DC values in these areas were higher in patients with better recovery at the twelfth than at the first week (P < 0.05), but such change was not found in patients with worse recovery.ConclusionsThese results indicate that network changes in the ipsilesional cerebellum are correlated with motor recovery following pontine infarction. Motor recovery mechanisms may vary between pontine and striato‐capsular infarcts, according to lesion location.
Differential sensitivity of structural, diffusion, and resting‐state functional MRI for detecting brain alterations and verbal memory impairment in temporal lobe epilepsy
Authors: Chang Yu‐Hsuan A. , Marshall Anisa , Bahrami Naeim , Mathur Kushagra , Javadi Sogol S. , Reyes Anny , Hegde Manu , Shih Jerry J. , Paul Brianna M. , Hagler Donald J. , McDonald Carrie R. 
Published: April 2019

AbstractObjectivesTemporal lobe epilepsy (TLE) is known to affect large‐scale gray and white matter networks, and these network changes likely contribute to the verbal memory impairments observed in many patients. In this study, we investigate multimodal imaging patterns of brain alterations in TLE and evaluate the sensitivity of different imaging measures to verbal memory impairment.MethodsDiffusion tensor imaging (DTI), volumetric magnetic resonance imaging (vMRI), and resting‐state functional MRI (rs‐fMRI) were evaluated in 46 patients with TLE and 33 healthy controls to measure patterns of microstructural, structural, and functional alterations, respectively. These measurements were obtained within the white matter directly beneath neocortex (ie, superficial white matter [SWM]) for DTI and across neocortex for vMRI and rs‐fMRI. The degree to which imaging alterations within left medial temporal lobe/posterior cingulate (LMT/PC) and left lateral temporal regions were associated with verbal memory performance was evaluated.ResultsPatients with left TLE and right TLE both demonstrated pronounced microstructural alterations (ie, decreased fractional anisotropy [FA] and increased mean diffusivity [MD]) spanning the entire frontal and temporolimbic SWM, which were highly lateralized to the ipsilateral hemisphere. Conversely, reductions in cortical thickness in vMRI and alterations in the magnitude of the rs‐fMRI response were less pronounced and less lateralized than the microstructural changes. Both stepwise regression and mediation analyses further revealed that FA and MD within SWM in LMT/PC regions were the most robust predictors of verbal memory, and that these associations were independent of left hippocampal volume.SignificanceThese findings suggest that microstructural loss within the SWM is pronounced in patients with TLE, and injury to the SWM within the LMT/PC region plays a critical role in verbal memory impairment.
Bone fractures from generalized convulsive seizures and status epilepticus—A systematic review
Authors: Grzonka Pascale , Rybitschka Anja , De Marchis Gian Marco , Marsch Stephan , Sutter Raoul 
Published: April 2019

AbstractObjectiveWe present a systematic review of the literature regarding types and anatomic distribution of fractures in association with generalized convulsive status epilepticus (GCSE) and convulsive seizures in adult patients accompanied by an illustrative case of a patient with GCSE and diffuse postictal pain from underlying bone fractures.MethodsThe library search engines PubMed and EMBASE were screened systematically using predefined search terms. All identified articles written in English were screened for eligibility by two reviewers. The preferred reporting items for systematic reviews and meta‐analyses guidelines were followed.ResultsThe screening of 3145 articles revealed 39 articles meeting the inclusion criteria. Among all fractures, bilateral posterior fracture‐dislocations of the shoulders were reported most frequently (33%), followed by thoracic and lumbar vertebral compression fractures (29%), skull and jaw fractures (8%), and bilateral femoral neck fractures (6%). Risk factors for seizure‐related fractures are seizure severity, duration of epilepsy, the use of antiseizure drugs known to decrease bone density, and a family history of fractures. Based on these findings, a three‐step screening procedure is proposed to uncover fractures in the postictal state. All studies were retrospective without standardized screening methods for seizure‐associated fractures resulting in a very low level of evidence and a high risk of bias.SignificancePosterior fracture‐dislocations of the shoulders, thoracic and lumbar vertebral compression, fractures of the skull and jaw, and bilateral femoral neck fractures are most frequently reported. Preventive measures including bone densitometry, calcium/vitamin D supplementation, and bisphosphonate therapy should be reinforced in epilepsy patients at risk of osteoporosis. As long as the effect of standardized screening of fractures is not investigated, it is too early to integrate such a screening into treatment guidelines. In the meantime, clinicians are urged to heighten awareness regarding seizure‐associated fractures, especially in patients with postictal pain, as symptoms can be unspecific and misinterpretation may impede rehabilitation.