bluuebunny/crossref_metadata_2025_split huggingface dataset:
The potential for predicting neonatal disabilities in preterm infants
Authors: Loskutova E. V. , Vakhitov Kh. M. , Sitdikova G. F. , Valieva N. R. , Volyanuk E. V. , Vakhitova L. F. , Yazdani E. V. 
Published: November 2024

The urgent task of modern pediatricians and neonatologists is to predict the course of the early neonatal period, during which the basic adaptive mechanisms of newborn children are in an unstable state. This is particularly important for the study of premature newborns, who are at high risk for an unfavorable outcome.Purpose. The aim of this study was to investigate the nature of early neonatal adaptation in children born between 32- and 36-weeks’ gestation, from mothers with burdened obstetric and gynecological histories and concomitant medical conditions.Material and methods. Out of 75 patients, we divided children born against a background of placental abruption and pre-eclampsia into separate groups. We provide a comparative analysis of their obstetric, gynecological, and medical histories, as well as their pre-dictive factors, somatic status dynamics, and laboratory and instrumental examinationsResults. Analysis of the data showed that in late preterm newborns, the presence of placental abruption in the history of 100% of cases led to the development of general somatic distress, with deterioration in hemodynamic and respiratory parameters, requiring transfer to the second phase of care. In children born preterm due to severe preeclampsia or other causes, stable severe conditions were observed in 33.3 and 39.6%, respectively, and 53.9 to 60% of infants required respiratory support.Conclusion. These findings allow for individualized assessment of a newborn’s condition in the first few days of life, based on predictive factors that may lead to a breakdown in compensatory responses.
Reactive arthritis in children
Authors: Khaertynov Kh. S. , Anokhin V. A. , Makarova K. A. , Bulatova A. Kh. , Yumasheva S. Yu. 
Published: November 2024

One of the common childhood illnesses is reactive arthritis, which develops during or soon after an infection.Purpose. The aim of the study was to study the etiology, clinical and laboratory manifestations of arthritis in children.Material and methods. The study included 37 children with arthritis aged 1 year 10 months to 15 years who were hospitalized at Kazan City Children’s Hospital № 1.Results. Reactive arthritis was diagnosed in 26 children, and juvenile idiopathic arthritis in 11. In 20 patients, reactive arthritis manifested itself as monoarthritis with predominant damage to the hip or knee joints – in 11 and 9 cases, respectively. Two children had ankle arthritis. In 4 cases there was oligoarthritis. Markers of infectious diseases were identified in 10 out of 26 children with reactive arthritis (38%). In 5 children (19%) IgM to Mycoplasma pneumonia was detected, in two (8%) – IgM to capsid antigen of Epstein–Barr virus, in one child (4%) – IgM to Chlamydia pneumonia. Two children had elevated ASLO values (more than 400 IU/ml). Inflammatory in the blood in 33 cases (89%) were characterized by increased erythrocyte sedimentation rate, the median of which was 22 mm/hour. Increased level of C-reactive protein and leukocytes in the blood were observed only in 9 (24%) and 7 (19%) children, respectively.Conclusion. Reactive arthritis in children mainly manifests as monoarthritis, with predominant damage to the hip or knee joints and in most cases was associated with Mycoplasma pneumonia.
Solubility, Flowability, and Setting Time of a New Endodontic Sealer based on Polycaprolactone
Authors: Yaltaghiyani Majid , Dizaj Solmaz Maleki , Shahi Shahriar , Sharifi Simin , Niaei Peiman , Moslemi Ehsan , Haghighi Danial 
Published: November 2024

Aim
One of the essential materials required for root canal treatment is a sealer. This study aimed to assess the solubility, flowability, and setting time of a new endodontic sealer compared to a commercial sealer, AH Plus.

Material and Methods
In this in vitro study, the new endodontic sealer was prepared using various proportions of the materials and compared with the control group (AH Plus sealer). Standard methods were used to measure solubility, flowability, and setting time. Statistical analysis was performed using t-tests and GraphPad Prism 9 software.

Results
The new sealer demonstrated lower solubility, higher flowability, and longer setting time compared to AH Plus.

Conclusion
Given the favorable results of the new sealer in this study, it is recommended for use in future clinical studies.
Effectiveness of the Offer of the Smoke Free Smartphone App Compared With No Intervention for Smoking Cessation: Pragmatic Randomized Controlled Trial
Authors: Jackson Sarah , Kale Dimitra , Beard Emma , Perski Olga , West Robert , Brown Jamie 
Published: November 2024

Background
Digital technologies offer the potential for low-cost, scalable delivery of interventions to promote smoking cessation.

Objective
We aimed to evaluate the effectiveness of the offer of Smoke Free—an evidence-informed, widely used app—for smoking cessation versus no support.

Methods
In this 2-arm randomized controlled trial, 3143 motivated adult smokers were recruited online between August 2020 and April 2021 and randomized to receive an offer of the Smoke Free app plus follow-up (intervention arm) versus follow-up only (comparator arm). Both groups were shown a brief message at the end of the baseline questionnaire encouraging them to make a quit attempt. The primary outcome was self-reported 6-month continuous abstinence assessed 7 months after randomization. Secondary outcomes included quit attempts in the first month post randomization, 3-month continuous abstinence assessed at 4 months, and 6-month continuous abstinence at 7 months among those who made a quit attempt. The primary analysis was performed on an intention-to-treat (ITT) analysis basis. Sensitivity analyses included (1) restricting the intervention group to those who took up the offer of the app, (2) using complete cases, and (3) using multiple imputation.

Results
The effective follow-up rate for 7 months was 41.9%. The primary analysis showed no evidence of a benefit of the intervention on rates of 6-month continuous abstinence (intervention 6.8% vs comparator 7.0%; relative risk 0.97, 95% CI 0.75-1.26). Analyses of all secondary outcomes also showed no evidence of a benefit. Similar results were observed on complete cases and using multiple imputation. When the intervention group was restricted to those who took up the offer of the app (n=395, 25.3%), participants in the intervention group were 80% more likely to report 6-month continuous abstinence (12.7% vs 7.0%; relative risk 1.80, 95% CI 1.30-2.45). Equivalent subgroup analyses produced similar results on the secondary outcomes. These differences persisted after adjustment for key baseline characteristics.

Conclusions
Among motivated smokers provided with very brief advice to quit, the offer of the Smoke Free app did not have a detectable benefit for cessation compared with follow-up only. However, the app increased quit rates when smokers randomized to receive the app downloaded it.

Trial Registration
ISRCTN ISRCTN85785540; https://www.isrctn.com/ISRCTN85785540

International Registered Report Identifier (IRRID)
RR2-https://onlinelibrary.wiley.com/doi/full/10.1111/add.14652
The Impact of Comment Slant and Comment Tone on Digital Health Communication Among Polarized Publics: A Web-Based Survey Experiment
Authors: Lu Fangcao , Tu Caixie 
Published: November 2024

Background
Public attitudes toward health issues are becoming increasingly polarized, as seen in social media comments, which vary from supportive to oppositional and frequently include uncivil language. The combined effects of comment slant and comment tone on health behavior among a polarized public need further examination.

Objective
This study aims to examine how social media users’ prior attitudes toward mask wearing and their exposure to a mask-wearing–promoting post, synchronized with polarized and hostile discussions, affect their compliance with mask wearing.

Methods
The study was a web-based survey experiment with participants recruited from Amazon Mechanical Turk. A total of 522 participants provided consent and completed the study. Participants were assigned to read a fictitious mask-wearing–promoting social media post with either civil anti–mask-wearing comments (130/522, 24.9%), civil pro–mask-wearing comments (129/522, 24.7%), uncivil anti–mask-wearing comments (131/522, 25.1%), or uncivil pro–mask-wearing comments (132/522, 25.3%). Following this, the participants were asked to complete self-assessed questionnaires. The PROCESS macro in SPSS (model 12; IBM Corp) was used to test the 3-way interaction effects between comment slant, comment tone, and prior attitudes on participants’ presumed influence from the post and their behavioral intention to comply with mask-wearing.

Results
Anti–mask-wearing comments led social media users to presume less influence about others’ acceptance of masks (B=1.49; P<.001; 95% CI 0.98-2.00) and resulted in decreased mask-wearing intention (B=0.07; P=.03; 95% CI 0.01-0.13). Comment tone with incivility also reduced compliance with mask-wearing (B=–0.44; P=.02; 95% CI –0.81 to –0.07). Furthermore, polarized attitudes had a direct impact (B=0.86; P<.001; 95% CI 0.45-1.26) and also interacted with both the slant and tone of comments, influencing mask-wearing intention.

Conclusions
Pro–mask-wearing comments enhanced presumed influence and compliance of mask-wearing, but incivility in the comments hindered this positive impact. Antimaskers showed increased compliance when they were unable to find civil support for their opinion in the social media environment. The findings suggest the need to correct and moderate uncivil language and misleading information in online comment sections while encouraging the posting of supportive and civil comments. In addition, information literacy programs are needed to prevent the public from being misled by polarized comments.
Barriers and Facilitators Affecting Access to Health Care for People With Syphilis: Protocol for a Scoping Review
Authors: Correia Rafaela Bezerra Façanha , Mourad Rafaela Prudlik , Dantas Janmilli da Costa , Silva Richardson Augusto Rosendo da 
Published: November 2024

Background
Syphilis is a systemic, preventable, and curable infection caused by the bacterium Treponema pallidum. Despite being treatable, syphilis continues to have a high incidence, with a resurgence observed even in countries with strong health surveillance systems. This highlights the need to understand the various strategies used globally to improve access to care for individuals with syphilis.

Objective
This scoping review aims to identify and map the barriers and facilitators affecting access to health care for people with syphilis.

Methods
This scoping review will follow the methodology outlined by the Joanna Briggs Institute. The search will be conducted across several databases, including PubMed/MEDLINE, Scopus, Embase, LILACS (Virtual Health Library), and CINAHL (EBSCO). In addition, sources of unpublished studies or gray literature will be explored. Studies focusing on access to health care for individuals with syphilis will be included, regardless of geographic location, country, or language. Two independent reviewers will assess the results, and data will be extracted using a tool specifically developed for this review. The extracted quantitative data will be presented in tables and analyzed using descending hierarchical classification, represented by a class dendrogram. Barriers and facilitators will be categorized into dimensions of access.

Results
Database searching began in October 2024. Full-text screening and review are expected to be completed in December 2024. Data extraction and analysis are expected to be completed by February 2025, and the final report will be completed in March 2025.

Conclusions
The findings of this scoping review, guided by this protocol, will elucidate the main barriers and facilitators that affect access to syphilis treatment. This study may contribute to the practices of health professionals, managers, and the academic community, and provide relevant information for the population.

Trial Registration
Open Science Framework Registries osf.io/kpsab; https://osf.io/kpsab

International Registered Report Identifier (IRRID)
PRR1-10.2196/63561
DRY POWDER INHALERS TECHNIQUE OF COMMUNITY PHARMACISTS: AN OBSERVATIONAL STUDY FROM LAHORE, PAKISTAN
Authors: Shahid Sara , Batool Sheza , Dua-E-Zahra Syeda , Rafique Uswa , Shuja Muhannid , Nadeem Muhammad Subhan , Hamza Muhammad , Amjad Umair , Iqbal Muhammad Zahid 
Published: November 2024

Introduction: Inaccurate utilization of various inhaler devices may severely influence the drug therapeutic effectiveness. The aim of this study is to evaluate the community pharmacist knowledge, attitudes and practice regarding the use of dry powder inhalers (DPIs).
Method: The present observational study was conducted for the evaluation of pharmacist’s knowledge and patient counseling attitude concerning the use of DPIs. A total of 114 community pharmacists from various community pharmacies of Lahore, Punjab were selected and a validated questionnaire was used to assess the knowledge of community pharmacists. The DPI technique presented by “National Heart, Lung and Blood Institute” was used as criteria for evaluation. The covert simulated patient approach was used to evaluate the DPI technique of pharmacists without any biasness.
Results: Out of 114, only 27.2% pharmacists presented adequate knowledge about the correct use of inhaler device (DPIs). Pharmacists from chain pharmacies presented higher adequacy 66.7% as compared to individual pharmacies i.e., 33.3%. Pharmacists whose working experience was more than 5 years presented better DPIs technique knowledge.
Conclusion: The study demonstrated that majority of the community pharmacist (72.8%) have inadequate dry powder inhaler technique at baseline. Setup type (Chain pharmacies) and work experience were the demographic variables that were positively associated with the adequate technique.

Peer Review History:
Received 15 July 2024; Reviewed 7 September 2024; Accepted 21 October; Available online 15 November 2024
Academic Editor: Dr. Asia Selman Abdullah, Pharmacy institute, University of Basrah, Iraq, asia_abdullah65@yahoo.com
Average Peer review marks at initial stage: 6.0/10
Average Peer review marks at publication stage: 7.5/10
Reviewers:
Antonio José de Jesus Evangelista, Federal University of Ceará, UFC, Brazil, tony_biomed@hotmail.com
Asmaa Ahmed Mohamed Ahmed Khalifa, Pharos University, Alexandria, Egypt, asmaa.khalifa@pua.edu.eg
AMELOBLASTOMA IN POPULATION OF YEMEN: ANALYZING THE PREVALENCE AND CLINIC PATHOLOGIC FEATURES OF AMELOBLASTOMA IN A YEMENI POPULATION
Authors: Al-Thobhani Samar Sultan , Da'er Sam Abd Alkarem , AL-Haddad Khaled A , Al-Moyed Khaled Abdulkarim , Al-Kibsi Taghreed Ahmed M , Al-Shamahy Hassan Abdulwahab 
Published: November 2024

Background and aims: Ameloblastoma is an uncommon tumor of odontogenic epithelium (ameloblasts, or the outer part of the teeth during development) that can be benign or malignant. It usually appears in the lower jaw rather than the upper jaw. The initial ameloblastoma is often treated with radical tumor resection. Analyzing the prevalence and clinic pathologic features of ameloblastoma in a Yemeni population was the goal.
Material and Methods: This retrospective cross-sectional study was carried out in all patients who were diagnosed with oral tumors at the targeted centers in Sana’a city (Al-Mamoon Center, Central Laboratory, and Al-Awlqy Laboratory Centers) in the period June 2020 to June 2022. This study is based on data taken from patients’s files that include age, gender, location, and histopathology. The study used descriptive statistics and SPSS version 26 for data analysis, describing quantitative non-parametric data using median and parametric data using mean and standard deviation.
Results: The ameloblastoma tumor prevalence was 8.8% of all oral tumors (330 cases). The mean age of the ameloblastoma patients was 31.10±11.4 (± SD) years and ranged from 11 to 80 years, with 1:1.2 males to females. The majority of ameloblastoma cases occurred in the lower jaw (93.1%; N=27), and the posterior part of the lower jaw was the main site for ameloblastoma tumors (79.3%; N=23), and 86.2%; N=23 of ameloblastoma was epithelial origin and 13.8%; N=4 was variegated origin. In terms of histological type, 65.5%; N=19 of the cases were not diagnosed, and the remaining cases showed a rate of 24.1%; N=7 for a multicystic tumor and 10.3%; N=3 for a unicystic tumor. 96.6%; N=28 of ameloblastoma cases were benign tumors, and only 3.4%; N=1 case was a malignant tumor.
Conclusions: The prevalence of ameloblastoma was significant, and these findings increase the awareness level of determent type of lesion for better diagnosis, management, and preventing measures.

Peer Review History:
Received 20 July 2024; Reviewed 6 September 2024; Accepted 16 October; Available online 15 November 2024
Academic Editor: Dr. Amany Mohamed Alboghdadly, Ibn Sina National College for Medical Studies in Jeddah, Saudi Arabia, amanyalboghdadly@gmail.com
Average Peer review marks at initial stage: 6.5/10
Average Peer review marks at publication stage: 7.5/10
Reviewers:
Dr. Gülay B Anadolu, Anadolu University, Eskisehir, Turkey, gbuyukko@anadolu.edu.tr
Dr. Sheikh Abdul Khaliq, Department of Pharmacy Practice, Faculty of Pharmacy, Hamdard University, Karachi, Pakistan, drwadhsheikh1974@gmail.com
EXPLORING HEALTHCARE MEDICATION-SKILLS, PROFESSIONALISM AND OPPORTUNITIES OF PHARMACY-BASED HEALTHCARE PROVIDERS IN MALAYSIA
Authors: Rahman Mohammad Nasrin Abdul , Wan Sulaiman Wan Mohd Azizi Bin , Azad Abul Kalam 
Published: November 2024

Background: Through qualitative and quantitative methods, this study will contribute to a deeper understanding of the evolving role of pharmacy-based healthcare providers in Malaysia and highlight strategies to optimize their impact within the healthcare framework. The evolving landscape of healthcare in Malaysia has placed increasing emphasis on the role of pharmacy-based healthcare providers in delivering patient-centered care. As healthcare systems worldwide shift toward more integrated approaches, pharmacists are uniquely positioned to contribute through their expertise in medication management and patient education. This study explores the current state of medication skills, professionalism, and the opportunities available for pharmacists in Malaysia.
Objective: This study investigates the knowledge, professionalism, and perceptions of pharmacy-based healthcare providers among students at University College MAIWP International (UCMI) in Malaysia.
Method: A total of 341 students participated in a survey assessing their understanding of pharmacists' roles, responsibilities, and contributions to healthcare.
Results: The findings indicate a strong recognition of pharmacists' importance in medication management and patient care, with 93.5% acknowledging their role in helping manage medications effectively. Despite a consensus on the necessity for higher education in pharmacy, 89.2% of respondents believed a high school diploma suffices to become a pharmacy practitioner. Additionally, both male and female students demonstrated similar levels of awareness regarding the diverse responsibilities of pharmacists beyond traditional roles.
Conclusions: The study highlights the need for greater integration of pharmacy professionals into the healthcare system and calls for enhanced educational initiatives to elevate the understanding of pharmacy roles among the general public and healthcare providers.

Peer Review History:
Received 21 July 2024; Reviewed 13 September 2024; Accepted 25 October; Available online 15 November 2024
Academic Editor: Dr. Emmanuel O. Olorunsola, Department of Pharmaceutics & Pharmaceutical Technology, University of Uyo, Nigeria, olorunsolaeo@yahoo.com
Average Peer review marks at initial stage: 6.0/10
Average Peer review marks at publication stage: 7.0/10
Reviewers:
Dr. Rima Benatoui, Applied Neuroendocrinology Laboratory, Faculty of Sciences, University of Annaba, Algeria. benattouiryma@gmail.com
Sheima Nadim Kadhim, Deparment of Pharmacology and Toxicology, College of pharmacy, University of Basra, Iraq. ph.sheimanadim@yahoo.com
PRECIPITAÇÃO PLUVIOMÉTRICA NA CULTURA DO TRIGO EM CASCAVEL-PR: IMPACTOS E CORRELAÇÕES
Authors: Santos Raynne Raphaela Rodrigues , Siqueira Jair Antonio Cruz , Santos Reginaldo Ferreira , Tokura Luciene Kazue , Vidotto Magno Luiz , Costa Regina Neves Ubial 
Published: November 2024

O trigo desempenha um papel vital na agricultura brasileira, especialmente em Cascavel, Paraná-Brasil. Destaca-se sua produção e importância econômica, enfatizando as diversas aplicações do trigo nas indústrias alimentícia, de ração animal e de bebidas. Ressalta-se o clima favorável e a necessidade de uma gestão eficiente da água para o cultivo, bem como os esforços em inovação tecnológica para otimizar a produção. O estudo teve por objetivo avaliar a influência da precipitação na produtividade da cultura de trigo, destacando a importância da distribuição temporal da precipitação ao longo das fases de desenvolvimento da planta. Métodos de análise de dados são descritos, juntamente com resultados que demonstram a correlação entre precipitação e rendimento de trigo. Fenômenos climáticos como El Niño e La Niña são considerados, com impactos variados na produção de trigo em Cascavel. Estratégias de mitigação são sugeridas para enfrentar os desafios climáticos e garantir a produção sustentável de trigo na região.
Establishing Lar Land Rights on Critical Land Within Forest Areas as a Strategy For Sustainable Forest Management
Authors: Dianto Dianto , Gunawan Jasardi 
Published: November 2024

Critical land within forest areas in Indonesia is expanding. This has an impact on natural disasters and climate change. This condition is a serious concern of the international world so that almost every international meeting on critical land issues and climate change is the main topic discussed by offering a variety of critical land management schemes but is considered ineffective. Behind the legal policy of handling critical land that is considered ineffective, there is long-standing traditional knowledge carried out by the people of Sumbawa, namely lar, which maintains a balance between ecology, social, economic and spiritual. The purpose of this research is to analyze the determination of Lar’s land rights on critical land in forest areas as a strategy for sustainable forest management. This research method is normative research with a conceptual approach, legislative approach and sociological approach. The results of this study, first, the concept of lar has three forms of land rights status, namely customary rights, rights, state-owned land and privately owned land so that state-owned land in the form of forest areas whose conditions are critical can be assigned lar land rights. Second, the concept of handling critical land in the area must be based on a balance between ecology, economy, social and spiritual. Third, the establishment of lar land rights in the forest area does not have to change the main function of the forest area. The conclusion of this research is that the establishment of lar land rights on critical land in forest areas can be carried out based on the balance between ecology, economy, social and spiritual without changing the function of the forest