bluuebunny/crossref_metadata_2025_split huggingface dataset:
Market response of US equities to domestic natural disasters: industry‐based evidence
Authors: Malik Ihtisham A. , Faff Robert W. , Chan Kam F. 
Published: June 2019

AbstractThis study investigates US industry‐based price response to domestic natural disasters over the period 1960–2015. Using an event study methodology, we estimate pre‐, during and post‐disaster impacts. We document a slower response in the pre‐disaster period than in the post‐disaster period. We further find that industries react differently to the same disaster and that reactions are not always negative. For example, meteorological disasters have a positive (negative) market impact on Gold (Banking). Moreover, we provide evidence that not every industry responds similarly to different disasters, e.g., Gold reacts positively (negatively) to meteorological (geophysical) disasters.
Characteristics of skin cancers among adult patients in an urban Malaysian population
Authors: Han Winn Hui , Yong Shin Shen , Tan Leng Leng , Toh Yen Fa , Chew Man Fong , Pailoor Jayalakshmi , Kwan Zhenli 
Published: June 2019

AbstractThere has been a rising incidence of skin cancers among Asians in recent years. We present a retrospective analysis of 106 skin cancers and analysed the demography, clinical subtypes of skin cancers and surgical techniques used for skin cancer treatment. In our population, skin cancers were most frequently basal cell carcinomas and diagnosed among ethnic Chinese patients.
Does human genome editing reinforce or violate human dignity?
Authors: Segers Seppe , Mertes Heidi 
Published: June 2019

AbstractGermline genome editing is often disapproved of at the international policy level because of its possible threats to human dignity. However, from a critical perspective the relationship between this emerging technology and human dignity is relatively understudied. We explore the main principles that are referred to when ‘human dignity' is invoked in this context; namely, the link with eugenics, the idea of a common genetic heritage, the principle of equal birth and broader equality and justice concerns. Yet the concept is also used in favour of germline genome editing as it might improve the overall well‐being of future generations. We conclude that dignity concerns do not justify a complete ban on safe heritable genome editing but should inform the implementation of side constraints to ensure that the value judgements about human traits that are inherent in this practice do not result in a diminished basic respect for those people affected by them.
Perceived changes and perceived transferability for treating intoxicated women victims of violence among emergency clinicians after an alcohol and other drugs training program
Authors: Marshall Amy , Schultz Tim , de Crespigny Charlotte 
Published: June 2019

AbstractIntroduction and AimsGiven the significant overlap between alcohol intoxication and violence against women, it is imperative that emergency clinicians are equipped to care for women presenting with both issues. This research aimed to explore emergency clinicians’ perceived changes and ability to apply training, particularly to intoxicated women victims of violence.Design and MethodsUsing a pre‐post questionnaire, 74 participants of the Emergency Mental Health Alcohol and Drug program were surveyed about their education/training, awareness and use of guidelines and tools, perceived changes in knowledge, skills and confidence and ability to apply the training.ResultsLow levels of previous education/training, awareness and use of best practice tools were reported. Although high rates of change in knowledge and confidence were reported after the program, a minority (38%) felt able to apply this to intoxicated women victims of violence. Working in an emergency department (P = 0.03) and having higher qualifications (P < 0.01) were the only significant factors affecting their ability to apply the training.Discussion and ConclusionsThe lower rates of perceived ability to apply to intoxicated women victims of violence suggest a deficit in ability to translate knowledge into practice. Higher qualifications affected respondents’ ability to apply the training to intoxicated women victims of violence, suggesting that general skills learned regarding translating knowledge into practice rather than specific content may have more impact. This research indicates that clinicians’ knowledge and confidence can be positively impacted by targeted education/training, but any future education/training must include knowledge translation skills.
The Zealandia Volcanic Complex: Further evidence of a lower crustal “hot zone” beneath the Mariana Intra‐oceanic Arc, Western Pacific
Authors: Stern Robert J. , Tamura Yoshihiko , Shukuno Hiroshi , Miyazaki Takashi 
Published: June 2019

AbstractThis paper addresses formation of felsic magmas in an intra‐oceanic magmatic arc. New bathymetric, petrologic, geochemical, and isotopic data for Zealandia Bank and two related volcanoes in the south‐central Mariana arc is presented and interpreted. These three volcanoes are remnants of an older andesitic volcano that evolved for some time and became dormant long enough for a carbonate platform to grow on its summit before reawakening as a rhyodacitic volcano. Zealandia lavas are transitional between low‐ and medium‐K and tholeiitic and calc‐alkaline suites. They define a bimodal suite with a gap of 56–58 wt% SiO2; this suggests that mafic and felsic magmas have different origins. The magmatic system is powered by mantle‐derived basalts having low Zr/Y and flat rare earth element patterns. Two‐pyroxene thermometry yields equilibration temperatures of 1000–1100 °C for andesites and 900–1000 °C for dacites. Porphyritic basalts and andesites show textures expected for fractionating magmas but mostly fine‐grained felsic lavas do not. All lavas show trace element signatures expected for mantle and crustal sources that were strongly melt‐depleted and enriched by subduction‐related fluids and sediment melts. Sr and Nd isotopic compositions fall in the normal range of Mariana arc lavas. Felsic lavas show petrographic evidence of mixing with mafic magma. Zealandia Bank felsic magmatism supports the idea that a large mid‐ to lower‐crustal felsic magma body exists beneath the south‐central Mariana arc, indicating that MASH (mixing, assimilation, storage, and homogenization) zones can form beneath intra‐oceanic as well as continental arcs.
Processing of dense bioinspired ceramics with deliberate microstructure
Authors: Le Ferrand Hortense , Bouville Florian 
Published: June 2019

AbstractThe architectures of biological hard materials reveal finely tailored complex assemblies of mineral crystals. Numerous recent studies associate the design of these local assemblies with impressive macroscopic response. Reproducing such exquisite control in technical ceramics conflicts with commonly used processing methods. Here, we circumvent this issue by combining the recently developed Magnetically Assisted Slip Casting (MASC) technique with the well‐established process of templated grain growth (TGG). MASC enables the local control over the orientation of platelets dispersed among smaller isotropic particles. After a high‐temperature pressureless heat treatment, the grains of the final ceramic follow the same orientation as of the initial platelets. This combination allows us to produce 95% dense alumina part with a grain orientation following any deliberate orientation. We successfully fabricated microstructures inspired from biological materials with ceramics that present periodically varying patterns with a programmable pitch down to a few tens of micrometers. The periodically textured dense ceramics exhibit matching variation of local hardness, confirming the capacity of the process to tailor local properties. This unique micrometer scale control over the local mechanical properties could be applied to adapt ceramic structures to complex loads using this inexpensive and scalable process. In systems where functional properties also depend on anisotropic grain orientation, the principle presented here could enable the creation of new multifunctional ceramics.
None‐rare‐earth activated Ca14Al10Zn6O35:Bi3+,Mn4+ phosphor involving dual luminescent centers for temperature sensing
Authors: Ding Yu , Guo Ning , Lü Xiang , Zhou Huitao , Wang Lu , Ouyang Ruizhuo , Miao Yuqing , Shao Baiqi 
Published: June 2019

AbstractWe proposed a new strategy for utilizing rare‐earth–free‐activated self‐referencing optical material with dual activators for temperature sensing, which was synthesized by conventional high‐temperature solid‐state method and was scarcely reported. Originating from the different thermal responses of Mn4+ and Bi3+ ions, a Mn4+/Bi3+‐based dual‐emitting fluorescence intensity ratio (FIR) as dual‐modal temperature signal for temperature sensing has been corroborated as a promising temperature sensing method. Due to the outstanding thermal resistance of activator Mn4+ (anti‐Stokes) benefiting from the unique 3dn electronic configurations and strong field strength of host, together with the energy transfer from Bi3+ to Mn4+ ions and excellent thermal quenching of Bi3+, this temperature‐sensitive phosphor displayed both an extensive detection temperature region ranging from 303 to 563 K and excellent absolute and relative sensitivity of 0.0147 K−1 and 1.21% K−1 respectively, both of which are higher than some foregoing reported optical materials. Furthermore, two well‐separated emission peaks at blue and red regions enabled an excellent signal discriminability and accurate temperature detection under the single‐wavelength excitation of 340 nm. In addition, freedom from rare‐earth ions contributed its possibility to be mass‐produced for meeting the needs of economic rationality, nontoxic and convenient synthesis. It is anticipated that this preliminary study would arouse peoples’ attention on exploring more novel dual activator‐based optical thermometric materials in absence of rare‐earth ions.
The origin of the modulated structure in Sr2CuO3+δ (δ = 0.4): [CuO2] in‐plane oxygen vacancy or apical oxygen vacancy?
Authors: Shen Xi , Cao Li‐Peng , Zhao Jian‐Fa , Wang Wei‐Peng , Liu Qing‐Qing , Yao Yuan , Li Jun‐Jie , Gu Chang‐Zhi , Chen Ming‐Wei , Jin Chang‐Qing , Yu Ri‐Cheng 
Published: June 2019

AbstractWe propose the question of the modulated structures of copper oxide is caused by the [CuO2] in‐plane oxygen vacancy or apical oxygen vacancy. Sr2CuO3+δ single‐crystal samples were prepared using high‐temperature and high‐pressure methods. The major phase of Sr2CuO3+δ (δ = 0.4) single‐crystal system is found to be constituted by the 5 a modulated structure with the Fmmm space group, which originates from the [CuO2] in‐plane oxygen vacancy appearing in octahedral Cu‐O. Besides, the presence of the [CuO2] in‐plane oxygen vacancy may obliterate the superconductivity of the system. Experimental results deduce that the oxygen vacancy may appear in the apical oxygen sites in high‐temperature copper oxide superconductors.
A comparison of elaborated and restricted feedback in LogEx, a tool for teaching rewriting logical formulae
Authors: Lodder Josje , Heeren Bastiaan , Jeuring Johan 
Published: June 2019

AbstractThis article describes an experiment with LogEx, an e‐learning environment that supports students in learning how to prove the equivalence between two logical formulae, using standard equivalences such as DeMorgan. In the experiment, we compare two groups of students. The first group uses the complete learning environment, including hints, next steps, worked solutions, and informative timely feedback. The second group uses a version of the environment without hints or next steps, but with worked solutions, and delayed flag feedback. We use pretest and posttest to measure the performance of both groups with respect to error rate and completion of the exercises. We analyse the loggings of the student activities in the learning environment to compare its use by the different groups. Both groups score significantly better on the posttest than on the pretest. We did not find significant differences between the groups in the posttest, although the group using the full learning environment performed slightly better than the other group. In the examination, which took place 5 weeks after the experiment, the group of students who used the complete learning environment scored significantly better than a control group of students who did not participate in the experiment.
Efficacy and safety of recombinant human interleukin‐11 in the treatment of acute leukaemia patients with chemotherapy‐induced thrombocytopenia: A systematic review and meta‐analysis
Authors: Liu ZhiRong , Wang Yaxuan , Yan Jingxin , Liu Junhong , Chen Bing , Zhang LuShun , Cheng Li 
Published: June 2019

AbstractRationale, aims, and objectivesCurrent meta‐analysis was conducted aiming to assess the efficacy and safety of recombinant human interleukin‐11 (rhIL‐11) in the treatment of acute leukaemia (AL) patients with chemotherapy‐induced thrombocytopenia (CIT).MethodsWe searched PubMed, Embase, Chinese National Knowledge Infrastructure database (CNKI), Cochrane Library, and Wan Fang Database on 4 July 2018.ResultsTen randomized controlled trials (RCTs) and two observational studies were included, which involved 754 AL patients with CIT. Pooled analysis demonstrated that rhIL‐11 was beneficial on CIT: recovery time of platelet count to 50 × 109/L [weight mean difference (WMD) = −4.19 days; 95% CI: −5.01, −3.37], recovery time of platelet count to 100 × 109/L (WMD = −4.45 days; 95% CI: −4.85, −4.06), platelet transfusion volume (WMD = −6.14 U; 95% CI: −9.20, −3.09), and the rate of haemorrhage (RR = 0.46; 95% CI: 0.36 to 0.61). Most adverse events associated with rhIL‐11 were mild to moderate.ConclusionOur findings suggest that rhIL‐11 is effective and safe in the treatment of CIT in patients with AL.
Supervised teaching and feedback improve physiotherapists' reporting of the International Classification of Functioning, Disability and Health in physiotherapeutic electronic patient records: A proof‐of‐concept randomized controlled trial
Authors: Lamsens Liesbeth , Janssens Lotte , Peers Koenraad , Caluwé Kim , Kiekens Carlotte , Van Eldere Johan , Vanhaecht Kris , Bruyneel Luk 
Published: June 2019

AbstractRationale, aims, and objectivesThe International Classification of Functioning, Disability and Health (ICF) is a landmark for physiotherapy to describe the full spectrum of human functioning, but ICF patient record completion could improve. In this study, we examine the effect of supervised teaching and personalized feedback on physiotherapists' completion and reporting of ICF in electronic patient records.MethodIn this proof‐of‐concept randomized controlled trial, the intervention group (10 physiotherapists) received supervised teaching and four rounds of personalized feedback on reporting of ICF components in electronic patient records. In the intervention group, review on patient record completion (n = 670 records) was performed at baseline, after teaching, after each of four feedback rounds, and at long‐term follow‐up. In the control group (five physiotherapists), which received no supervised teaching nor personalized feedback, review (n = 140 records) was performed at baseline, after the third feedback round of the intervention group, and at follow‐up.ResultsAfter the third round of feedback (95% vs 72% completion; β, 2.68; 95% CI, 0.62‐4.74), patient record completion was significantly higher in the intervention group. This was also true for following ICF components: “activity” (93% versus 64% completion; β, 3.03; 95% CI, 1.52‐4.54), “participation” (50% versus 14% completion; β, 3.67; 95% CI, 1.79‐5.55), and “personal factors” (35% versus 20% completion; β, 2.10; 95% CI, 0.63‐3.57). These statistically significant and clinically relevant effects persisted at long‐term follow‐up. For “environmental factors,” effects after the third round of feedback (75% vs 30% completion; β, 1.88; 95% CI, 0.63‐3.13) disappeared at follow‐up. Reporting of “body functions and structures” improved similarly across groups.ConclusionsSupervised teaching and personalized feedback are active ingredients of an intervention to improve reporting of ICF components in physiotherapeutic patient records.
The venodilation effects of tapping versus massaging for venipuncture
Authors: Yasuda Kae , Sato Saki , Okada Kazunori , Yano Rika 
Published: June 2019

AbstractAimTo compare the effectiveness of tapping and massaging venodilation techniques by evaluating venous cross‐sectional area, venous depth, venous palpation score, and questionnaire responses of study participants.MethodsThis study had a quasi‐experimental design. Between August 2016 and October 2016, healthy adult volunteers (n = 30, mean ± standard deviation of age: 22.3 ± 2.2 years) were enrolled in this study. Three venodilation techniques were evaluated: the application of a tourniquet (Control Group), the application of a tourniquet and tapping of the participant's forearm (Tapping Group), and the application of a tourniquet and massaging of the participant's forearm (Massage Group).ResultsIn all three groups, venous cross‐sectional areas increased significantly after the application of the venodilation technique. The change ratio of venous cross‐sectional area was significantly larger in the Massage Group than in the Control Group. Additionally, 83.3% of the participants selected massaging as their preferred venodilation technique, stating the technique was comfortable and provided a feeling of relief.ConclusionsNo significant differences were observed between the degrees of venodilation that were achieved using the three investigated venodilation techniques. Nonetheless, massaging was deemed the most effective technique after considering the participants' subjective comments.
Chloroplast phylogenomic data support Eocene amphi‐Pacific early radiation for the Asian Palmate core Araliaceae
Authors: Valcárcel Virginia , Wen Jun 
Published: June 2019

AbstractTraditional phylogenies based on analysis of multiple genes have failed to obtain a well‐resolved evolutionary history for the backbone of the Asian Palmate group of Araliaceae, the largest clade of the family. In this study, we applied the genome skimming approach of next‐generation sequencing to address whether the lack of resolution at the base of the Asian Palmate tree is due to molecular sampling error or the footprint of ancient radiation. Twenty‐nine complete plastid genomes of Araliaceae (17 newly sequenced) were analyzed (RAxML, Beast, Lagrange, and BioGeoBears) to provide the first phylogenomic reconstruction of the group (95% of genera included). As a result, the early divergences of the Asian Palmate group have been clarified but the backbone of its core is not totally resolved, with short internal branches pointing to an ancient radiation scenario. East Asia is inferred as the most likely ancestral area for the Asian Palmate group (from late Paleocene to Eocene) from which early colonization of the Neotropics is inferred during the Eocene. The radiation of the core Palmate group took place during the late Eocene, most likely in the context of the Boreotropical hypothesis. Recurrent episodes of southward migration (to the tropics) coupled with northern latitude local extinctions (promoting geographic isolation of lineages) followed by northward expansion (promoting contact of lineages that erased the trace of preceding geographic isolation) are hypothesized to have linked to the alternation of the cold and warm periods of the Eocene.
Pharmacokinetics of altrenogest in gilts
Authors: Xiao Hongzhi , Sun Pan , Sun Feifei , Qiu Jicheng , Wang Jie , Wang Jianzhong , Lin Yalong , Gong Xiaohui , Zhang Lu , Zhang Suxia , Cao Xingyuan 
Published: June 2019

AbstractAltrenogest, a synthetic progestogen, is characterized by its estrus synchronization in mares, ewes, sows, and gilts. To investigate the pharmacokinetic profile and evaluate its accumulation in gilts, 18 oral doses of 20 mg altrenogest/gilt/day were given to eight healthy gilts at an interval of 24 hr. Plasma samples were collected, and altrenogest was determined by ultra‐high‐performance liquid chromatography with mass spectrometry. WinNonlin 6.4 software was used to calculate the pharmacokinetic parameters through noncompartmental model analysis. After the first administration (D 1), the pharmacokinetic parameters, including Tmax, Cmax, and the elimination half‐life (T1/2λz), were similar to those observed after the final administration (D 18). However, the mean residence time at D 1 was significantly lower than D 18. As a whole, the mean steady‐state plasma concentration (Css), degree fluctuation (DF), accumulation factor (Rac), and area under the plasma concentration–time curve in steady state (AUCss) were 22.69 ± 6.15 ng/ml, 270.64 ± 42.51%, 1.53 ± 0.23, and 544.63 ± 147.49 ng hr/ml, respectively. These results showed that after 18 consecutive days of oral administration of altrenogest, plasma concentrations of altrenogest had a certain degree of fluctuation, without significant accumulations.
Late presented congenital myasthenic syndrome with novel compound heterozygous CHRNE mutations mimicking seronegative myasthenia gravis
Authors: Nakano Yumiko , Tsunoda Keiichiro , Yamashita Toru , Mitsui Jun , Sato Kota , Takemoto Mami , Hishikawa Nozomi , Ohta Yasuyuki , Toda Tatsushi , Tsuji Shoji , Abe Koji 
Published: June 2019

AbstractWe found a late presented congenital myasthenic syndrome (CMS) patient with novel CHRNE gene mutations. Although our patient has shown blepharoptosis since youth, fatigable muscle weakness began at age 71. Genetic analysis revealed novel compound heterozygous CHRNE mutations (c.1032+2T>G, c.1306_1307 delGA). His myasthenic symptoms were well managed by oral anti‐cholinesterase drug until he died at 82‐year‐old. The present case showed mild myasthenic symptoms with very late presentation and slow progression. Late presented CMS is often underdiagnosed; therefore, genetic testing is important to distinguish it from other myasthenic disease.
Termination of desynchronization rhythm and restoration of cardiac resynchronization by left‐sided ventricular premature complexes
Authors: Barold S. Serge , Kucher Andreas 
Published: June 2019

AbstractCardiac resynchronization devices that sense left ventricular (LV) activity and can detect interruptions of resynchronization therapy are able to record all forms of desynchronization rhythms, which are triggered by misalignment of LV timing cycles. We report five cases of this desynchronization rhythm that were terminated by isolated left‐sided ventricular premature complexes (LVPC) undetected by the right ventricular (RV) channel and unaccompanied by changes in the duration of the RV pacing cycles. In three cases, the devices did not even sense the LVPCs responsible for desynchronization termination. The restoration of resynchronization in our cases is in contrast to the traditional termination mode that is invariably associated with changes in the duration of the RV cycles.