bluuebunny/crossref_metadata_2025_split huggingface dataset:
Az Ehlers–Danlos-szindrómák korszerű osztályozása és multidiszciplináris tünettana
Authors: Ralovich Fanni Virág , Kiss Norbert , Horváth Krisztina , Kárpáti Sarolta , Medvecz Márta 
Published: April 2019

Abstract: In this review article, the authors summarize the clinical aspects of the novel classification of Ehlers–Danlos syndrome, which is a group of rare, hereditary connective tissue disorders. The leading symptom of the Ehlers–Danlos syndrome group is joint hypermobility, skin hyperextensibility and generalized tissue fragility. Ehlers–Danlos syndrome displays a high clinical and genetic heterogeneity and harbors many multidisciplinary properties. Certain subtypes only affect the quality of life, while other forms may lead to severe, even fatal vascular or intestinal complications. Last year, based on the data of various international genotype-phenotype correlation studies of large populations, a new classification of the syndrome’s clinical subtypes was introduced. The novel international nosology of Ehlers–Danlos syndromes published in 2017 delineates 13 clinical subtypes, describes their genetic background and defines major and minor diagnostic criteria for each subtype. We gathered the complex, multidisciplinary symptoms of Ehlers–Danlos syndromes in a table to assist the diagnosis from a differential diagnostic point of view. In the clinical practice, the proper diagnosis of patients affected by the Ehlers–Danlos syndrome group is essential to give optimal clinical care and to prevent the development of severe complications. Orv Hetil. 2019; 160(16): 603–612.
A nyelés képességének helyreállítása lúgivás utáni nyelőcsőszűkületben
Authors: Kotsis Lajos , Kostic Szilárd , Heiler Zoltán , Vadász Pál 
Published: April 2019

Abstract: The authors discuss their experience in the surgical treatment of caustic stenosis in the upper gastrointestinal tract. They present operative solutions using isoperistaltic transverse colonic segment in oesophageal stenosis caused by gastric outlet obstruction, or when these two presented together. Further indications for the above were bronchial or tracheo-oesophageal fistulas and oesophageal perforation. Late adaptation of the colonic grafts were measured by radiokinematography and histochemistry. The overall morbidity was 4.9%. Postoperative salivary fistulas closed spontaneously. Late postoperative complications (13.5%) were treated successfully. The multihaustral motility of the graft prevented the reflux, while the altered mucopolysaccharides of the colonic mucosa prevented the ulcer formation. Orv Hetil. 2019; 160(16): 613–618.
A Zenker-diverticulumok transcervicalis és transoralis sebészi kezelésének összehasonlító vizsgálata, rövid és hosszú távú eredmények
Authors: Andrási László , Ábrahám Szabolcs , Simonka Zsolt , Paszt Attila , Rovó László , Lázár György 
Published: April 2019

Abstract: Introduction and aim: We present our experience with open (transcervical diverticulectomy, cricomyotomy) and transoral surgery (transoral stapler diverticulostomy) for Zenker diverticulums. Method: Between 1 January 2006 and 31 December 2016, 29 patients were examined with a symptom-causing Zenker diverticulum. In 13 cases, transcervical surgery, in 16 cases, transoral surgery were performed. Perioperative and long-term results were evaluated and compared. Results: Patients were operated on after an average of 31 months with complaints. In both groups, the leading symptoms were severe dysphagia and severe regurgitation. No intraoperative complication was detected. In the transoral group, one patient had to be reoperated on for bleeding, another patient developed pneumonia in the transcervical group. The average duration of the surgeries (42.5 versus [vs.] 98 minutes, p<0.001), the time to oral feeding (2.9 vs. 4.6 days, p<0.001) and the mean hospital stay (7.3 vs. 9.7 days, p<0.001) were significantly shorter in the transoral group than the transcervical group. 15 patients were completely symptomless postoperatively. After transcervical treatment, complaints were developed in 2 cases (moderate dysphagia and hoarseness). After transoral surgery, recurrent symptoms were observed in 6 patients, 4 had to be reoperated transcervically due to severe regurgitation. Conclusion: Transoral stapler diverticulostomy is a fast procedure and offers short hospital stay especially in comorbid, aged patients and intermedium diverticulum size. In the long term, some of the patients may require reintervention due to persistent regurgitation. The transcervical approach has higher perioperative morbidity, which can be performed in patients with less than 3 cm or large diverticulum size. Orv Hetil. 2019; 160(16): 629–635.
PERAN LPKSM AL-JABBAR DALAM PENYELESAIAN SENGKETA JAMINAN FIDUSIA DI KABUPATEN SUMEDANG
Authors: Salam Acep Fahmi Abdullah 
Published: April 2019

AbstrakLembaga Perlindungan Konsumen Swadaya Masyarakat (LPKSM) Al-Jabbar dibentuk berdasarkan Pasal 44 Undang-undang Nomor 8 Tahun 1999 tentang Perlindungan Konsumen. Lembaga ini, sebagaimana terjabar dalam pasal tersebut berfungsi sebagai penerima aspirasi atau keluhan konsumen yang dirugi­­kan serta menangani masalah penyelesaian sengketa kon­sumen dan pelaku usaha. Salah satu penyelesaian sengketa yang dilakukan lembaga tersebut adalah sengketa fidusia. Tulisan ini mendeskripsikan bagaimana LPKSM tersebut melaksanakan tugasnya dalam penyelesaan sengketa fidusia antara pelaku usaha dengan konsumennya. Dari analisis normatif ditemukan bahwa lembaga tersebut belum menerapkan secara utuh ketentuan dalam undang-undang yang memayungi berdirinya lembaga tersebut.Kata Kunci: Perlindungan Konsumen, LPKSM, Penyelesaian Sengketa
PERLINDUNGAN HAK PENYANDANG DISABILITAS TUNA GRAHITA SEBAGAI SAKSI KORBAN DALAM PROSES PERADILAN PIDANA DI INDONESIA
Authors: Barkah Aah Laelatul 
Published: April 2019

Abstrak Setiap orang yang lahir di dunia tidak sama, ada yang dilahirkan sempurna dan ada yang kurang sempurna atau disebut sebagai penyandang disabilitas. Salah satunya adalah tuna grahita atau retardasi mental. Dengan perkembangan otak yang kurang sempurna, penyan­dang disabilitas jenis ini cenderung mudah menjadi objek kejahatan. Permasalahan muncul ketika mereka diharuskan untuk menjadi saksi korban atas tindak kejahatan yang mereka alami mengingat keter­batasan yang mereka miliki. Tulisan ini menjabarkan bentuk perlindung­an bagi penyandang disabilitas dengan melakukan analisis deskriptif terhadap Undang-undang Nomor 8 Tahun 2016 tentang Penyandang Disabilitas sebagai payung hukum pemerintah Indonesia dalam menjamin perlindungan bagi para penyandang disabilitas. Peradilan pidana atas kejahatan yang menimpa penyandang disabilitas dilakukan sebagaimana proses peradilan pidana pada umumnya. Yang membedakannya adalah saksi korban didampingi oleh seorang ahli selama persidangan.Kata Kunci: Perlindungan, Disabilitas, Proses Peradilan
PENYEBARAN UJARAN KEBENCIAN DALAM PERSFEKTIF HUKUM PIDANA ISLAM
Authors: Hasibuan Zainudin 
Published: April 2019

AbstrakPerkembangan teknologi informasi saat ini seperti pedang bermata dua, karena selain memberikan kontribusi bagi peningkatan kesejahteraan, kemajuan, dan peradaban manusia, sekaligus menjadi sarana efektif melakukan perbuatan melawan hukum. Permasalahan hukum yang sering kali dihadapi adalah ketika terkait dengan pe­nyampaian informasi, komunikasi, dan/atau data secara elektronik. Kebebasan berpendapat seolah dibatasi oleh UU ITE tahun2008 ini, sehingga perlu adanya penjelasan atau kajian mengenai perbuatan ujaran kebencian yang dimaksud dalam UU ini dalam Pasal 28 ayat (2) Jo 45 ayat (2). Tinjauan Hukum Pidana Islam menggunakan dua istilah untuk tindak pidana yaitu jinayah dan jarimah, objek utama kajian fiqh jinayah yaitu al-rukn al-syar’i, al- rukn al-madi dan al-rukn al-adabi, jika dikaitkan dengan materi pembahasan, dimana hal ini erat hubungannya dengan al-rukn al-madi, maka objek utama kajian fiqih jinayah meliputi tiga bagian pokok, yaitu Jarimah Qishahs /diyat, Hudud, dan Ta’zir. Maka perbuatan tindak pidana ujaran ke­bencian tergolong kepada jarimah ta’zir, yaitu jarimah yang tidak ditentukan bentuk ataupun sanksinya dalam nash.Kata Kunci: Teknologi, Ujaran Kebencian, Pidana Islam
Post Radiotherapy Lesions of the Heart Valves. Principles of Diagnosis and Results of Treatment
Authors: Muratov R. M. , Babenko S. I. , Sachkov A. S. , Soboleva N. N. , Andrianova E. A. 
Published: April 2019

Background. The use of radiation therapy for the treatment of tumors of the chest сan lead to the development of cardiac pathology, including that of the valves and coronary arteries. Study aim: to analyze the specifics of post-radiation lesions of the valvular apparatus and coronary arteries, and to assess the immediate results and risks of surgical correction of detected defects. Materials and methods. In the Emergency department of surgery of acquired heart disease of A. N. Bakulev National Medical Research Center of Cardiovascular Surgery in the period from 2004 to 2017 were examined and operated 46 patients aged 35–81 years (mean age 56±12.4 years, 80 % women). The period from primary irradiation of the chest to surgical treatment of valvular pathology ranged from 4 to 40 years. Indications for thoracic radiotherapy were Hodgkin’s lymphoma in 23 patients (50 %), breast cancer – in 20 (43 %). Results. Stenosis of the aortic valve was the leading defect in 42 patients (91 %). According to coronary angiography, coronary artery disease was diagnosed in 31 patients (67 %). Isolated aortic valve prosthesis was performed in 14 (30 %) patients, other operations were combined. Hospital mortality was 11 % (5 patients). There were no deaths among patients who underwent radiation therapy after mastectomy. Main nonlethal complications were: pericardial effusion in 6 patients (13 %), hydrothorax requiring repeated pleural punctures in 5 patients (11 %). Conclusion. The variety of clinical manifestations of radiation heart disease and its progressive nature emphasize the need for long-term dynamic observation of patients after thoracic irradiation in order to timely identify the pathology and eliminate the risk of sudden cardiac complications and the development of severe heart failure decompensation.
Carbenoxolone Could Deteriorate Streptozotocin-induced Diabetes through Induction of Heat Shock Protein 70 and IFN-γ in C57BL/6 Mice
Authors: Rasouli Mehdi , Jafari-khataylou Yaser , Ashrafi-Helan Javad 
Published: April 2019

Type 1 diabetes (T1D), a spontaneous autoimmune disease, is associated with destruction of insulin-producing β-cells in the pancreas. Since some heat shock proteins (HSP), such as HSP70 exert a protective effect in both tissues and cells, the present study was conducted to elucidate the effects of carbenoxolone (CBX) as an HSP70 inducer on T1D.
The disease was induced in male C57BL/6 mice using streptozotocin (STZ) and subjects were allocated to therapeutic 1 and therapeutic 2 groups, as well as negative and positive control groups. The treated mice (therapeutic 1 and therapeutic 2 groups) received 50 mg/kg CBX intraperitoneally every 24 hours, in the therapeutic 1 group the drug was injected before and after disease induction whereas in the therapeutic 2 group the drug was injected only after disease induction. Serum fasting blood sugar (FBS) level, cytokines production (Interferon-gamma (IFN-γ), Interleukin 10 (IL-10), and IL-17), serum HSP70 level and CD4+CD25+Foxp3+ regulatory T cell (Treg) frequency measurements were outperformed 14 days after the last STZ injection.
Our results showed that in the treated groups, serum HSP70, IFN-γ, and IL-17 levels were increased in contrast to the untreated groups. The IL-10 level was markedly decreased in comparison to untreated diabetic mice (p<0.05). Moreover, it was found that the frequency of Tregs in treated mice was lower in comparison to the untreated mice but the difference was not significant (p>0.05).
Our results confirm that CBX might through HSP70 induction, followed by increasing IFN-γ level leads to suppression of IL-10 production in diabetic mice resulted in toxic effects on pancreatic islet beta cells and deteriorating of disease.
The Review of in Vitro and in Vivo Studies over the Glycyrrhizic Acid as Natural Remedy Option for Treatment of Allergic Asthma
Authors: Fouladi Saloomeh , Masjedi Mohsen , Ganjalikhani Hakemi Mazdak , Eskandari Nahid 
Published: April 2019

Allergic asthma is the most common type of allergy which have become increasingly prevalent in all around the world. Airway eosinophilic inflammation is a major feature of allergic asthma. Glycyrrhiza uralensis (licorice) is one of the regular herbs in traditional Chinese medicine (TCM) as it has many effects on the immune system such as anti-inflammatory and immune regulatory activity; antiviral and antitumor effects.
This review focuses on the "licorice” components, mainly glycyrrhizic acid (GA) and derivatives structure that evaluate its effects on the allergic asthma. We performed searching articles in Pubmed, Web of Science, and Scopus data bank from 1990 to 2017. The search syntax were: "glycyrrhizin" OR " glycyrrhizic acid" OR " glycyrrhizinic acid" OR" glycyrrhiza glabra" OR " liquorice root" OR "G. glabra" OR "glycyrrhizic Acid" AND "allergic asthma" OR "bronchial asthma" OR "asthma, bronchial" OR "airway hyper-responsiveness" OR "airway inflammation".
Several molecular mechanisms and inflammatory mediators may possibly be responsible for efficacy of glycyrrhizin. Some in vitro studies indicated to the fact that possible mechanisms of anti-inflammatory effects could be through reduction of pro-inflammatory mediator's synthesis that motivates eosinophil, basophils and mast cells to release cytokines for the differentiation of T helper cells into Th2 cells to secrete interleukins.
Furthermore, some transcription factors such as NF-κB, STAT6 and HDAC2 go between modulations of anti-asthmatic effects. The last but not the least it can be said that glycyrrhizin is potentially a good herbal drug with the lower most adverse effects for asthma treatment.
The Stimulatory Effects of Medicinal Plants on β2-adrenoceptors of Tracheal Smooth Muscle
Authors: Shakeri Farzaneh , Ghorani Vahideh , Saadat Saeideh , Gholamnezhad Zahra , Hossein Boskabady Mohammad 
Published: April 2019

Medicinal plants have been identified and used as primary sources in prevention and treatment of pulmonary diseases (mainly obstructive pulmonary diseases) from ancient times due to various pharmacological activities. In this review, the stimulatory effects of extracts, some fractions and constituents of medicinal plants on β2-adrenoceptors which could be used as possible therapeutic agents in the future were reviewed.
Various databases including; Medline, PubMed, ScienceDirect, Scopus, and Google Scholar were searched using stimulatory effect, β2-adrenoceptors, possible mechanism, tracheal smooth muscle (TSM), medicinal plants and their constituents as keywords from 1985 to 2017.
All studied plants including; Nigella sativa, Rosa damascena, Thymus vulgaris, Carum copticom, Carum carvi, Zataria multiflora, Crocus sativus, Cuminum cyminum, Liomnia acidissima, Portulaca oleraceae, Satureja hortensis, Ephedra sinica and Achillea millefolium showed relaxant effect on tracheal smooth muscle with a stimulatory effect on β2-adrenoceptors mechanism.
The studied plants and their constituents could be of therapeutic value in clinical practice as a bronchodilatory drug by β2-adrenoceptors stimulatory mechanism for treatment of obstructive pulmonary diseases.
CLIMATE CHANGE-FOOD SECURITY-FINANCIAL ASSETS NEXUS: EVIDENCE FROM INDONESIA
Authors: Yuniarti Dini , Purwaningsih Yunastiti , Soesilo AM , Suryantoro Agustinus 
Published: April 2019

Purpose: The aim of the study is to investigate the position of household food security when they face climate change and examine the influence of financial asset on food security dynamic. Additionally, we investigate the impact of livelihood assets such as human capital, financial capital, social capital, natural capital, and physical capital on food security dynamic.
Methodology: There are four categories of food security dynamic namely household that always secure, improved, worse, and always food insecure. Taking the case on Kulonprogo, Yogyakarta Special Region, we use primary data with a longitudinal survey when El Nino (2015) and La Nina (2016). The sample size is 107 households of Program KeluargaHarapan’s receiver. To examine the association between financial assets and food security dynamic we used Multinomial Logit Regression.
Results: The results of the study indicates that households in the face of climate change did not experience significant changes in food security positions in both seasons (El Nińo and La Nińa). Mild food insecurity still dominates impoverished households.
Implications: Thus, the proportion of households that experienced improvement or decline was dominated by mild food insecurity. Furthermore, financial assets such as saving and credit can enhance poor household food security. Meanwhile, there are not all household livelihood assets improve food security yet; only human capital and natural capital can improve household food security. The appropriate food security strategies can be the focus on financial sector intervention program.
Adaptación de cofias metálicas confeccionadas con dos técnicas: cera pérdida colado por centrifugación convencional e inducción
Authors: Requena Cisneros Silvio Over , Loarte Campos Micarla Yanira , Zelada Ladrón de Guevara Cinthya Cecilia , Flores Valverde Yovana Elisa , Castillo Andamayo Diana Esmeralda , Quintana del Solar Martín Gilberto 
Published: April 2019

Nuevas técnicas nos están permitiendo migrar de la técnica de cera perdida colado por centrifugado convencio- nal (CPCC) a técnicas como la cera perdida colado por inducción (CPCI). Objetivos: Comparar la discrepancia marginal e interna de cofias unitarias de aleación Cobalto-Cromo (Co-Cr) sobre una línea de terminación cham- fer, confeccionadas con dos técnicas: CPCC y CPCI, determinando cual técnica tuvo mejor adaptación marginal e interna. Material y Métodos: Se fabricaron13 cofias metálicas unitarias de aleación Co-Cr para cada técnica a evaluar. Se utilizó la réplica de silicona para evaluar las discrepancias marginales e internas, cada muestra fue seccionada en cruz en sentido vestíbulo-palatino y en sentido mesio-distal, luego con un estéreomicroscopio se evaluó la zona cervical, axial y oclusal. Resultados: Se evaluó los supuestos de normalidad con la prueba de Shapiro-Wilk. Los análisis estadísticos fueron la prueba t de Student y U Mann-Whitney. La CPCI obtuvo una menor discrepancia marginal e interna en comparación con la CPC pero no se encontró diferencias estadísti- camente significativas (p>0,05) entre ambas técnicas. Conclusiones: Aunque en la mayoría de los puntos de evaluación las cofias realizadas mediante la CPCI presento mejores valores de adaptación marginal e interna en comparación con la CPCC estos resultados sólo son valores descriptivos que no fueron concluyentes, ya que en la mayoría de los puntos evaluados no existió diferencia estadísticamente significativa (p>0,05). Observamos que la mayoría de los valores de ambas técnicas se encuentran dentro del rango clínicamente aceptable.
Anionic Surfactant and Heavy Oil Interaction during Surfactant-Steam Process
Authors: Alshaikh Murtdha , Lee Yeh Seng , Hascakir Berna 
Published: April 2019

Abstract
Coinjecting of steam with surfactant to recover heavy crude oil is studied. Performance production of this process is achieved through analysis of the formed emulsions which provides mechanistic understanding of crude oil and surfactant interaction in the presence of steam.
Surfactants are used to reduce the interfacial tension between water and oil. While the nonpolar tail of a surfactant stays in the oil phase, its polar side remains in the water phase. Surfactant literature is in general built on light oil reservoirs, which form mostly by nonpolar hydrocarbons. However, for high-viscosity crude, the situation can be different due to its high-polarity components. Asphaltenes and resins are known as the polar components of crude oil, while saturates and aromatics are the nonpolar. Therefore, steam and surfactant-steam flood experiments were conducted on a heavy crude oil sample with low API gravity, high viscosity, and high polar fraction content. Firstly, the crude oil sample was blended with anionic surfactant solution via magnetic stir and formed emulsion phases were characterized. To determine steam’s effects, emulsions were exposed to steam and evaluated by optical microscopy, Fourier Transform Infrared Spectroscopy, dielectric constant, and zeta potential measurements. Secondly, core flood experiments were carried on to evaluate the surfactant-steam process. Lastly, produced oil samples from two flooding tests were analyzed under optical microscopy and the impact of polarity and ionic bond interaction were investigated on produced oil, produced water, and produced polar asphaltene samples.
Dielectric constant measurements is introduced as an indirect method to determine polarity and enhance emulsion characterization for heavy crude oils. It was observed that the high amounts of asphaltenes and resins in crude oil favor emulsion formation in steam process due to polar fractions of crude oil which are known as emulsifiers. However, zeta potential measurements showed that in surfactant-steam process emulsion formation is promoted due to electrical attraction of anionic head of surfactant with inorganic surface morphology of asphaltenes.
Our results provide important information on how the surfactant-steam process can be successful in heavy oil reservoirs that consist different amounts of polar components with high inorganic content. Developing the right emulsion characterization tools such as electrical properties will assist in choosing the best surfactant candidates for different heavy crude oils with high polar components, facilitating the surfactant-steam flooding processes.
Economic Nano-Additive to Improve Cement Sealing Capability
Authors: Tabatabaei Maryam , Dahi Taleghani Arash , Alem Nasim 
Published: April 2019

Abstract
The primary objective of this study is introducing low-cost graphite nanoplatelets (GNPs) for oilwell cementing that improves long-term wellbore isolation and the durability of the hydrated cement. To seek this goal, we first propose two methodologies to modify the surface properties of the nano-additives to disperse them in the cement paste. There are essentially two significant incentives for the surface modification of nanoparticles: (1) a proper dispersion of nanoparticles in the slurry and (2) enhance the interaction between these nanoparticles and the cementitious matrix. It is expected that this interaction will improve the cement integrity by controlling micro-cracks initiation and their propagation. Then, experiments are conducted to assess enhanced mechanical behavior of the new cement nanocomposite.