bluuebunny/crossref_metadata_2025_split huggingface dataset:
On Chip Interdigitated Micro‐Supercapacitors Based on Sputtered Bifunctional Vanadium Nitride Thin Films with Finely Tuned Inter‐ and Intracolumnar Porosities
Authors: Robert Kevin , Douard Camille , Demortière Arnaud , Blanchard Florent , Roussel Pascal , Brousse Thierry , Lethien Christophe 
Published: June 2018

AbstractMicro‐supercapacitors (MSC) are considered as promising miniaturized electrochemical energy storage devices for Internet of Things applications. Unfortunately, the technological readiness level of these devices is still at the lab scale with the development of individual prototypes due to the difficulty to produce high performance porous electrode material with microelectronic equipment available in pilot production lines. Here, the collective fabrication of on chip MSC based on sputtered porous vanadium nitride (VN) bifunctional material is reported. For the first time in the field of MSC, the porosity of the sputtered VN thin films is fine‐tuned at the nanoscale level in order to produce high capacitance and high conductive electrodes. Interdigitated MSC based on optimized VN thin films are fabricated on silicon wafers using microelectronic facilities. 2 μWh cm−2/10 mWh cm−3 energy densities are reached while keeping a high power density (10 mW cm−2/>50 W cm−3) owing to high electrical conductivity of VN layers. Sputtered vanadium nitride thin films are demonstrated to be suitable pseudocapacitive electrodes and highly conductive current collectors for MSC applications. These findings represent a major advance in order to go toward the large‐scale deployment of such miniaturized power sources.
Probing the Crystal Structure Landscape by Doping: 4‐Bromo, 4‐Chloro, and 4‐Methylcinnamic Acids
Authors: Chakraborty Shaunak , Joseph Sumy , Desiraju Gautam R. 
Published: June 2018

AbstractAccessing the data points in the crystal structure landscape of a molecule is a challenging task, either experimentally or computationally. We have charted the crystal structure landscape of 4‐bromocinnamic acid (4BCA) experimentally and computationally: experimental doping is achieved with 4‐methylcinnamic acid (4MCA) to obtain new crystal structures; computational doping is performed with 4‐chlorocinnamic acid (4CCA) as a model system, because of the difficulties associated in parameterizing the Br atom. The landscape of 4CCA is explored experimentally in turn, also by doping it with 4MCA, and is found to bear a close resemblance to the landscape of 4BCA, justifying the ready miscibility of these two halogenated cinnamic acids to form solid solutions without any change in crystal structure. In effect, 4MCA, 4CCA and 4BCA form a commutable group of crystal structures, which may be realized experimentally or computationally, and constitute the landscape. Unlike the results obtained by Kitaigorodskii, all but two of the multiple solid solutions obtained in the methyl‐doping experiments take structures that are different from the hitherto observed crystal forms of the parent compounds. Even granted that the latter might be inherently polymorphic, this unusual observation provokes the suggestion that solid solution formation may be used to probe the crystal structure landscape. The influence of π⋅⋅⋅π interactions, weak hydrogen bonds and halogen bonds in directing the formation of these new structures is also seen.
Combining Fullerenes and Zwitterions in Non‐Conjugated Polymer Interlayers to Raise Solar Cell Efficiency
Authors: Liu Yao , Sheri Madhu , Cole Marcus D. , Emrick Todd , Russell Thomas P. 
Published: June 2018

AbstractPolymer zwitterions were synthesized by nucleophilic ring‐opening of 3,3′‐(but‐2‐ene‐1,4‐diyl)bis(1,2‐oxathiolane 2,2‐dioxide) (a bis‐sultone) with functional perylene diimide (PDI) or fullerene monomers. Integration of these polymers into solar cell devices as cathode interlayers boosted efficiencies of fullerene‐based organic photovoltaics (OPVs) from 2.75 % to 10.74 %, and of non‐fullerene‐based OPVs from 4.25 % to 10.10 %, demonstrating the versatility of these interlayer materials in OPVs. The fullerene‐containing polymer zwitterion (C60‐PZ) showed a higher interfacial dipole (Δ) value and electron mobility than its PDI counterpart (PDI‐PZ), affording solar cells with high efficiency. The power of PDI‐PZ and C60‐PZ to improve electron injection and extraction processes when positioned between metal electrodes and organic semiconductors highlights their promise to overcome energy barriers at the hard‐soft materials interface of organic electronics.
A Molecular Ferroelectric Showing Room‐Temperature Record‐Fast Switching of Spontaneous Polarization
Authors: Sun Zhihua , Yi Xianfeng , Tao Kewen , Ji Chengmin , Liu Xitao , Li Lina , Han Shiguo , Zheng Anmin , Hong Maochun , Luo Junhua 
Published: June 2018

AbstractFast switching of spontaneous polarization (Ps) is one of the most essential requirements for ferroelectrics used in the field of data storage. However, in contrast to inorganic counterparts, the low operating frequency (<500 Hz) for molecular ferroelectrics severely hinders their large‐scale applications. Herein, for the first time, we achieved the room‐temperature fastest switching of the Ps in a new molecular ferroelectric, N‐methylmorpholinium trinitrophenolate (1), which displays notable ferroelectricity (Ps=3.2 μc cm−2). Strikingly, electric polarizations of 1 have been switched under a record‐high frequency of 263 kHz, and this performance remains stable without any obvious fatigue after ca. 2×105 switching cycles. To our knowledge, 1 is the first organic ferroelectric to switch polarization at such a high operating frequency, exceeding the majority of organic ferroelectrics, which opens up new possibilities for its potential in the field of non‐volatile memory.
N‐Heterocyclic Carbene (NHC)‐Organocatalyzed Kinetic Resolutions, Dynamic Kinetic Resolutions, and Desymmetrizations
Authors: Wang Zhongyao , Pan Dingwu , Li Tingting , Jin Zhichao 
Published: June 2018

AbstractThe last couple of decades have witnessed tremendous development within N‐heterocyclic carbene (NHC) organocatalysis. NHCs have been used as powerful organic catalysts in asymmetric synthesis. Although great achievements have been made in asymmetric NHC catalysis, their applications in kinetic resolution (KR), dynamic kinetic resolution (DKR), and desymmetrization processes have been relatively less developed. Moreover, limited activation modes have been involved in these processes. This review provides an overview of the NHC‐organocatalyzed KR, DKR, and desymmetrization reactions in the preparation of chiral functional molecules. The aim is to highlight both the importance and elegance of these methods in the construction of challenging chiral compounds and to provide our own perspective on future development in this direction.
Rail road tie preservative recovery and conversion to hydrocarbon fuels: a conceptual process design and economics
Authors: Houston Ross , Haber Holly , Kim Pyoungchung , Kim Jae‐Woo , Lloyd Jeff , Labbé Nicole , Abdoulmoumine Nourredine 
Published: June 2018

AbstractIn the USA, over 21 million wood railroad ties are produced per year to replace approximately 20 million used ties that have provided primary service in railroad tracks over 40 years. Traditionally, used ties have been processed for energy recovery, typically as boiler fuel. However, recent US Environmental Protection Agency (US EPA) regulations and the low cost of natural gas is leading to preservative‐treated ties being used increasingly as landfill. This study evaluated the economic viability of a process that aims to recover the preservatives from used ties and subsequently convert the extracted wood ties to hydrocarbon fuels (gasoline and diesel blendstocks) using an integrated biorefinery concept.This techno‐economic analysis considered three plants, geographically spread across the USA to minimize transportation costs, with a capacity of 1769 dry tons per day based on a yearly available used railroad‐tie inventory estimated at 2.33 million tons. Under the baseline case scenario, the process produces 237 tons per day of recovered creosote and 69 293 and 74 922 gal per day of gasoline and diesel, respectively. The total capital investment for an nth plant is estimated at $380 million. The minimum fuel selling price (MFSP) is determined to be $2.52 per gasoline gallon equivalent (GGE) at a 10% required internal rate of return in 2016 US dollars, with a simple payback period of 9 years after tax and a market price of recovered creosote of $2.80/gal. The sensitivity analysis reveals that plant size, internal rate of return, and feedstock cost have the most impact on the MFSP. © 2018 Society of Chemical Industry and John Wiley & Sons, Ltd
Percutaneous access versus surgical cut down for TAVR: Where do we go from here?
Authors: Ates Ismail , Cilingiroglu Mehmet 
Published: June 2018

Key Points

Transcatheter aortic valve replacement is now the standard of care for severe symptomatic aortic stenosis patients who are at high‐surgical risk.
Percutaneous approach without a surgical cut down has been increasingly adapted by some centers in USA.
Percutaneous approach seems to be associated with shorter hospital stay, similar short and late vascular complications, less disabling stroke, similar mortality as well as significantly less hospital cost. However, this technique also requires operators to be able to manage any vascular complications using advanced endovascular interventions to achieve complete hemostasis.
Overlapping bio‐absorbable scaffolds: Aim for D2D technique?
Authors: Khan Asaad A. , Dangas George D. 
Published: June 2018

Key Points

The results of overlapping metallic stents have been concerning but this practice is often unavoidable in the setting of long or tortuous lesions, diameter discrepancy of proximal and distal vessel, and for residual dissections.
Theoretically, bio‐absorbable scaffolds may carry an advantage over metallic stents due to the progressive resorption of the scaffold theoretically rendering the overlap a non‐issue; this has not been clinically evident.
Since stent/scaffold overlap cannot be entirely avoided, improved stent delivery/deployment and scaffold design modification may reduce complications in this complex patient subset.
Dual Site Lewis‐Acid Metal‐Organic Framework Catalysts for CO2 Fixation: Counteracting Effects of Node Connectivity, Defects and Linker Metalation
Authors: Epp Konstantin , Semrau A. Lisa , Cokoja Mirza , Fischer Roland A. 
Published: June 2018

AbstractThree Zr‐oxo‐cluster node and porphyrin‐linker based MOFs, MOF‐525, PCN‐222 and PCN‐224 exhibiting different linker connectivities of 12, 8 and 6 and their porphyrin‐linker metalated analogues, were synthesized and tested as catalysts for CO2 fixation by using the cycloaddition of CO2 and propylene oxide to propylene carbonate as the test reaction. In general, the catalytic activity correlates with the connectivity of the Zr‐oxo nodes. The lowest connected PCN‐224 (6‐fold) exhibits a superior catalytic activity in this series, while higher connected PCN‐222 (8‐fold) and MOF‐525 (12‐fold) are less active. Interestingly, the catalytic activity of the higher connected MOFs significantly depends on defects. The (ideally) 12‐connected MOF‐525, however exhibiting 16% of missing linker defects, features a higher catalytic activity compared to the 8‐connected PCN‐222 with less defects. The overall catalytic activity is increased in dual site catalysts when the porphyrin linkers are metalated with Mn(III) and Zn(II) centers, which are acting as additional Lewis acid sites. Here, the metalated MOFs with higher connectivity exhibit the highest activity.
Graphene‐Oxide‐Loaded Superparamagnetic Iron Oxide Nanoparticles for Ultrasensitive Electrocatalytic Detection of MicroRNA
Authors: Islam Md. Nazmul , Gorgannezhad Lena , Masud Mostafa Kamal , Tanaka Shunsuke , Hossain Md. Shahriar A. , Yamauchi Yusuke , Nguyen Nam‐Trung , Shiddiky Muhammad J. A. 
Published: June 2018

AbstractWe report the electrocatalytic activity of a new class of superparamagnetic nanoparticles, graphene‐oxide‐loaded iron oxide (GO/IO hybrid material), towards the reduction of ruthenium hexaammine(III) chloride (Ru(NH3)6]3+, RuHex). Leveraging the electrocatalytic activity of the GO/IO hybrid material and the signal enhancement capacity of [Ru(NH3)6]3+/[Fe(CN)6]3− in an electrocatalytic cycle, an ultrasensitive and specific electrochemical sensor was developed for the detection of cancer‐related microRNA (miRNA). Using the direct affinity interaction between RNA and graphene oxide, magnetically isolated and purified target miRNA were directly adsorbed onto a screen‐printed electrode modified with the GO/IO hybrid material. The detection was enabled by chronocoulometric (CC) readout of charge‐compensating [Ru(NH3)6]3+ followed by an enhancement in CC charge display through the Ru(NH3)6]3+/[Fe(CN)6]3− system. We demonstrate an excellent limit of detection of 1.0 fM by accurately detecting miR‐21 in synthetic samples and showcase its clinical utility in ovarian cancer cell lines with high sensitivity (ten cells) and good reproducibility (% RSD=<5 %, for n=3).
Simultaneous Multiplex Potentiostatic Electroanalysis with Liquid‐Junction‐Removed Reference Electrode System using a Closed Bipolar Electrode
Authors: Inoue Kumi Y. , Ikegawa Miho , Ito‐Sasaki Takahiro , Takano Shinichiro , Shiku Hitoshi , Matsue Tomokazu 
Published: June 2018

AbstractA novel liquid‐junction‐removed reference electrode system was developed for simultaneous multiplex amperometry using a closed bipolar electrode. The liquid junction between the reference cell and the sample cell was replaced by a bipolar electrode to ensure electron conductivity in lieu of ionic conductivity in conventional systems. Under the condition where the redox reaction of the analyte at the bipolar electrode in the sample cell was a limiting process, voltammetric and amperometric measurements were performed for quantitative detection of the analytes. After characterization of the system, a chip‐type device was fabricated with six sample cells and one reference cell. Simultaneous determination of ferrocene methanol was conducted in six solutions in the 0.1–0.5 mM range. This is the first demonstration of the simultaneous multiplex determination of analytes with a liquid‐junction‐removed system. Although the potential control problem (which is different to the liquid potential problem of conventional liquid junction) still remains because of the increase of the solid–liquid interface, this system is expected to solve some problems associated with the liquid junction of the reference electrode, including sample contamination by chloride ions and the complicated process of fabricating a reference electrode on a chip.
Morphology Diversity of L‐Phenylalanine‐Based Short Peptide Supramolecular Aggregates and Hydrogels
Authors: Martí‐Centelles Rosa , Escuder Beatriu 
Published: June 2018

AbstractSupramolecular aggregates and hydrogels of diverse morphologies can be obtained by replacing the widely studied aromatic N‐capping of phenylalanine derivatives by long alkyl chains. Simple changes in chain length and number of phenylalanine residues lead to a diversity of nanostructures including networks of fibers of different handedness and flat nanosheets. Moreover, additional morphologies could be achieved by a simple pathway selection. These results evidence the impact that small structural and methodological changes have on the self‐assembly of small peptide fragments and recall its relevance for the understanding of protein aggregation as well as for the fine control of peptide material properties for applications.
Self‐Assembled Nanofibrilar Networks: Boosting Hydrogelation Efficiency by Replacement of a Pyridine Moiety by a Quinoline One
Authors: Angulo‐Pachón César A. , Díaz‐Oltra Santiago , Ojeda‐Flores Juan J. , Falomir Eva , Galindo Francisco , Miravet Juan F. 
Published: June 2018

AbstractA new molecular hydrogelator consisting of a L‐Valine derivative with appended quinoline units behaves as a supramolecular superhydrogelator forming gels at such low concentrations as 0.8 mM (0.05% w/w). On the other hand, an analogue compound containing a pyridine moiety is found to be a poor gelator, forming gels at 19 mM. The gels are pH sensitive because of the protonation of the heterocycle and show microcrystallinity. The rheological properties and biocompatibility are also reported.
Natural food colorants derived from onion wastes: Application in a yoghurt product
Authors: Mourtzinos Ioannis , Prodromidis Prodromos , Grigorakis Spyros , Makris Dimitris P. , Biliaderis Costas G. , Moschakis Thomas 
Published: June 2018

AbstractThe valorization of onion (Allium cepa) solid wastes, a 450 000 tonnes/year waste in Europe, by a green extraction method is presented. Polyphenols of onion solid wastes were extracted using eco‐friendly solvents, such as water and glycerol. The 2‐hydroxypropyl‐β‐cyclodextrin was also used as a co‐solvent for the augmentation of the extraction yield. The process has been optimized by implementing a central composite face centered design of experiments, with two replicates in the central point, taking into consideration the following independent variables: glycerol concentration, cyclodextrin concentration and temperature. The assessment of the extraction model was based on two responses: the total pigment yield and the antiradical capacity. LC‐MS analysis was also employed in order to identify polyphenols and colorants of the obtained extracts. The main polyphenols found were quercetin and quercetin derivatives and the main colorant was cyanidin 3‐O‐glucoside. The extract was also tested as a food colorant in a yoghurt matrix. The onion leaf extract was found to be a stable natural colorant and could be utilized as an alternative ingredient to synthetic coloring agents.
Human primary CD34+ cells transplantation for critical limb ischemia
Authors: Lian Weishuai , Hu Xiaoxiao , Pan Long , Han Shilong , Cao Chuanwu , Jia Zhongzhi , Li Maoquan 
Published: June 2018

BackgroundThe goal of this study was to characterize the properties of human CD34+ cells in culture and investigate the feasibility and efficacy of CD34+ transplantation in a mouse model of limb ischemia and in patients with no‐option critical limb ischemia.MethodsHuman CD34+ cells isolated from peripheral blood and grown in culture for up to four passages stained positively for the surface markers CD34 and CD133 and showed high viability after cryopreservation and recovery. Seven days after surgery to induce limb ischemia, ischemic muscles of nude mice were injected with CD34+ cells. Two weeks later, mice were scored for extent of ischemic injury, and muscle tissue was collected for immunohistochemical analysis of vascular endothelial cells and RT‐PCR analysis of cytokine expression.ResultsInjury scores of CD34+‐treated, but not control, mice were significantly different before and after transplantation. Vascular density and expression of VEGF and bFGF mRNAs were also significantly increased in the treated mice. Patients with severe lower extremity arterial ischemia were injected with their own CD34+ cells in the affected calf, foot, or toe. Significant improvements were observed in peak pain‐free walking time, ankle‐brachial index, and transcutaneous partial oxygen pressure. These findings demonstrate that growth of human CD34+ cells in vitro and cryopreservations are feasible.ConclusionSuch cells may provide a renewable source of stem cells for transplantation, which appears to be a feasible, safe, and effective treatment for patients with critical limb ischemia.
Cover Image, Volume 98, Issue 10
Authors: Kancheva Vessela D , Slavova‐Kazakova Adriana K , Angelova Silvia E , Kumar Prashant , Malhotra Shashwat , Singh Brajendra K , Saso Luciano , Prasad Ashok K , Parmar Virinder S 
Published: June 2018

The cover image, by Vessela Kancheva et al., is based on the Research Article Protective effects of new antioxidant compositions of 4‐methylcoumarins andrelated compounds with DL‐α‐tocopherol and L‐ascorbic acid, DOI: 10.1002/jsfa.8892.
image
Studies on the Biocompatibility of Poly(diethyl vinyl‐phosphonate) with a New Fluorescent Marker
Authors: Schwarzenböck Christina , Vagin Sergei I. , Heinz Werner R. , Nelson Peter J. , Rieger Bernhard 
Published: June 2018

AbstractUtilization of group transfer polymerization for the synthesis of poly(diethyl vinylphosphonate) (PDEVP) allows its controlled end‐group functionalization. Thus, a new fluorescent chromophore/PDEVP conjugate is prepared and subjected to biocompatibility tests on two different human cell lines. In contrast to the previous studies, the tagged polymer is not absorbed by cells from the solution and has nearly no impact on cell mortality rate.
Are measures of pain sensitivity associated with pain and disability at 12‐month follow up in chronic neck pain?
Authors: Moloney Niamh , Beales Darren , Azoory Roxanne , Hübscher Markus , Waller Robert , Gibbons Rebekah , Rebbeck Trudy 
Published: June 2018

AbstractObjectivesPain sensitivity and psychosocial issues are prognostic of poor outcome in acute neck disorders. However, knowledge of associations between pain sensitivity and ongoing pain and disability in chronic neck pain are lacking. We aimed to investigate associations of pain sensitivity with pain and disability at the 12‐month follow‐up in people with chronic neck pain.MethodsThe predictor variables were: clinical and quantitative sensory testing (cold, pressure); neural tissue sensitivity; neuropathic symptoms; comorbidities; sleep; psychological distress; pain catastrophizing; pain intensity (for the model explaining disability at 12 months only); and disability (for the model explaining pain at 12 months only). Data were analysed using uni‐ and multivariate regression models to assess associations with pain and disability at the 12‐month follow‐up (n = 64 at baseline, n = 51 at follow‐up).ResultsUnivariable associations between all predictor variables and pain and disability were evident (r > 0.3; p < 0.05), except for cold and pressure pain thresholds and cold sensitivity. For disability at the 12‐month follow‐up, 24.0% of the variance was explained by psychological distress and comorbidities. For pain at 12 months, 39.8% of the variance was explained primarily by baseline disability.ConclusionsNeither clinical nor quantitative measures of pain sensitivity were meaningfully associated with long‐term patient–reported outcomes in people with chronic neck pain, limiting their clinical application in evaluating prognosis.
Liquid Sucrose Consumption Promotes Obesity and Impairs Glucose Tolerance Without Altering Circulating Insulin Levels
Authors: Burke Susan J. , Batdorf Heidi M. , Martin Thomas M. , Burk David H. , Noland Robert C. , Cooley Christopher R. , Karlstad Michael D. , Johnson William D. , Collier J. Jason 
Published: June 2018

ObjectiveMultiple factors contribute to the rising rates of obesity and to difficulties in weight reduction that exist in the worldwide population. Caloric intake via sugar‐sweetened beverages may be influential. This study tested the hypothesis that liquid sucrose intake promotes obesity by increasing serum insulin levels and tissue lipid accumulation.MethodsC57BL/6J mice were given 30% sucrose in liquid form. Changes in weight gain, body composition, energy expenditure (EE), and tissue lipid content were measured.ResultsMice drinking sucrose gained more total body mass (TBM), had greater fat mass, and displayed impaired glucose tolerance relative to control mice. These metabolic changes occurred without alterations in circulating insulin levels and despite increases in whole body EE. Lipid accrued in liver, but not skeletal muscle, of sucrose‐consuming mice. Oxygen consumption (VO2) correlated with fat‐free mass and moderately with TBM, but not with fat mass. ANCOVA for treatment effects on EE, with TBM, VO2, lean body mass, and fat‐free mass taken as potential covariates for EE, revealed VO2 as the most significant correlation.ConclusionsWeight gain induced by intake of liquid sucrose in mice is associated with lipid accrual in liver, but not skeletal muscle, and occurs without an increase in circulating insulin.