bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identification of catechol dioxygenases of acinetobacter species, with improved ability to degrade crude oil
Authors: AL-Kadmy Israa M.S. , Suhail Ahmed , Abid Suhad Abbas , Aziz Sarah Naji , Abed Al-Maamoon H. , Al-sallami Karrar Jasim 
Published: October 2019

Abstract
Background: Various microbes involved in alkanes degradation or reducing organics oil products have been identified among. The goal of this work was to screen the soil bacteria with potential ability to degrade alkanes and characterized using a combination of genetic and physiological methods.Methods: The microbial species of soil sample was isolated and the loss of hydrocarbon was calculated periodically by gravimetric analysis. Isolated bacterial strain with potential ability to degrade the engine oil in Baghdad city was further tested for hydrocarbon-degrading abilities using 2, 6-DCPIP. Colonies of bacteria were counted using serial dilution methods of the soil sample. One of the highly bioactive degrading strains ISN53 was selected and a different fraction of crude extract were analyzed for their hydrocarbon degrading activity. The purified active fraction characterised in LC/MS and SDS PAGE. Presence of chlorocatechol dioxygenases was checked by PCR and expression was analyzed in RT PCR. The envelope of ISn21 isolate was checked for any changes under different conditions using microbial adhesion to the hydrocarbon test (MATH). Results: Serratia marcesens (Sm53) and Acinetobacter venetianus (ISn21) were isolated and ISn21 showed maximum growth on the third day and up to 72% degradation on the 7th day of incubation. LC-MS/MS spectrometry analysis identified the bioactive enzyme catechol dioxygenases in crude extract. The purified catechol dioxygenases enzyme had 35 kDa weight which showed the maximum activity between 48 to 72 hour of incubation. The expression of its gene was 2 fold more than control the maximum expression was observed at 60 to 72 hours of incubation. ISn21 was extremely hydrophobic both in MMV and in LB medium.Conclusion: Using a naturally available resources would be better with efficiency at degrading diesel. Use of like microorganisms during bioremediation operation might supply worthy advances in this important biotechnological/ biological domain.
An observational study of the effects of telmisartan on insulin resistance in hypertensive patients with chronic kidney disease undergoing hemodialysis
Authors: suprapti budi , Dharma Bayu , Drik Mahadri , Izzah Zamrottul , Nilamsari Wenny , Alderman Chris 
Published: October 2019

Abstract
Background In the clinical setting, the activity of telmisartan in decreasing insulin resistance has been proven superior to other antihypertensive drugs in hypertensive patients. However, there has been no published study in determining the effect of telmisartan on insulin resistance in hypertensive chronic kidney disease patients undergoing hemodialysis.Objective To analyze the effect of telmisartan on insulin resistance in hypertensive patients undergoing hemodialysis.Method It was a prospective observational cohort study in 16 chronic kidney disease patients undergoing regular hemodialysis and using telmisartan who met the inclusion criteria.Results Sixteen patients received telmisartan, 12 were male patients and four were female. The mean age was 45 ± 8 years and the mean body mass index was 22.85 ± 1.99. Hypertensive chronic kidney disease was the highest etiology (56%) for hemodialysis. Mean percentage of fasting plasma insulin and homeostatic model assessment of insulin resistance concentratons decreased significantly by 22.6% (P<0.05) and 22.9% (P<0.05) respectively after 3-month administration. On the other hand, the mean percentage of fasting plasma glucose concentrations declined by 2.9% (P=0.187, Zcount<1.96) after 3-month of treatment.Conclusion Administration of telmisartan for three months decreases insulin resistance significantly in hypertensive patients undergoing hemodialysis.
Young adult renal service: Does having a dedicated young adult service make difference to patient outcomes?
Authors: Williamson Samantha , Myton Jemma , Evison Felicity , Kerecuk Larissa , Lipkin Graham , Pankhurst Tanya 
Published: October 2019

Abstract
Background Young adults with chronic renal disease face the rigours of adolescence alongside the responsibility of safeguarding their own health. They have poorer renal transplant outcomes than other age groups presumed due to non-adherence with medication and clinic attendance. We had set up a Young Adult Service and aimed to understand whether this had reduced distress in young adults and impacted positively on renal transplant survival. Methods Transplant patients aged 16-24 years who had transferred to adult renal services between 2000 and 2006, prior to commencement of a dedicated young adult service, were studied as historical controls. This patient group was compared to the current young adult transplant cohort. Missed appointments, serial renal function and transplant survival was collected. The current young adult cohort were assessed for markers of ‘distress’ and this was correlated with clinic attendance and transplant outcomes. Young adults were surveyed for their opinion of the service. Results Five year transplant survival increased from 65% to 98% concurrent with Young Adult Service commencement. 60% of patients reported distress and this correlated with missed clinic appointments. By offering more appointments to this group and increasing support, neither distress nor missed appointments impacted transplant outcomes despite the high risk in this patient cohort. The service was well received by young adults. Conclusion A dedicated Young Adult Renal Service may protect from poor renal transplant outcomes by providing increased holistic support.
Self-medication with antibiotics of parents of different nationalities in China: analysis of irrational use of antibiotics from demand side
Authors: Zhou Zhongliang , Zhao Dantong , Zhang Huarui , Shen Chi , Zhu Liang , Zhao Yaxin , Cao Dan , Ren Yangling , Si Yafei , Ma Siwei , Fang Yu 
Published: October 2019

Abstract
Background: There is an increasing trend on practicing self-medication with antibiotics in both developed and developing countries. Bacterial resistance caused by antibiotic use has become an important public health concern. This study contributes to explore the effect of different demanders but the same supplier on parental self-medication with antibiotics for children. It intends to analyze the difference in self-medication with antibiotics of parents of different nationalities for children under the same health service supplier in the context of Chinese policies, and compare their differences in knowledge, attitudes and behaviors about antibiotics.
Methods: A cross sectional study was designed to investigate all 310 parents of different nationalities (Chinese, other Asian and Occidental) whose children were studying in an International Department of an International School in Xi'an, Shaanxi, China on September 2018. Pearson Chi-square test and Binary Logistic Regressions were used to analyze the data.
Results: The results showed the rate of parental self-medication with antibiotics for children was 13.85%, where parents of three nationalities were respectively 20.10%, 5.00% and 2.67% ( P <0.001). Chinese parents were respectively 8.221 ( P <0.01) and 6.086 ( P <0.05) times more likely to have self-medication with antibiotics for children compared to Occidental parents in two regression models controlling different confounders. Occidental parents had higher correct rate of knowledge, attitudes and behaviors about antibiotics than Chinese parents and followed by other Asian parents in total ( P <0.001).
Conclusions: The study found that parents' nationality was an influencing factor on parental self-medication with antibiotics for children that Chinese parents were easier to self-medicate for children than Occidental parents. Occidental parents performed better than Chinese and other Asian parents in knowledge, attitudes and behaviors about antibiotics. It is recommended for health administration not only to strengthen the supervision and regulation to health service supplier, but also health education to parents on knowledge, attitudes and behaviors about antibiotics.
Key words: China; Self-medication with antibiotics; Parents of different nationalities; Knowledge; Attitudes; Behaviors
Social and Family Factors as Determinants of Exercise Habits in Japanese Elementary School Children: The Super Shokuiku School Project
Authors: Sawa Satomi , Sekine Michikazu , Yamada Masaki , Fukazawa Yugo , Hiraku Yusuke 
Published: October 2019

Abstract
Background

Many studies have already reported on the relationship between exercise habits and health among schoolchildren. However, few have examined social and/or family factors as determinants of exercise habits. This study investigated factors related to both dislike and lack of physical activity among schoolchildren.

Methods

This study’s participants included 1,984 school children (1,001 boys and 983 girls) aged between 6 and 13 from the Super Shokuiku School Project in January 2016. A survey was conducted to assess sex, grade level, physical activity, lifestyle, overall health, enrichment of school life, social background, and parental lifestyles. Both the dislike and lack of physical activity were defined as poor exercise habits; correlates were analyzed using a logistic regression.

Results

“Lack of close friends” had the strongest links with both dislike (adjusted odds ratio [OR] 5.30; 95% confidence interval [CI], 2.78-10.1) and lack of (adjusted OR 5.40; 95%CI, 2.81-10.4) physical activity. Further, children who engaged in long periods of screen time and lacked parental communication also tended to dislike and lack physical activity. Children with mothers who were unemployed (housewife) and had undesirable lifestyles as well as those with poor health were also more likely to lack physical activity.

Conclusion

Social and family factors (e.g., close friends) may be determinants of exercise habits among schoolchildren independently of their own lifestyle factors. Although a longitudinal study is needed to determine causality, substantial attention should thus be paid to these factors when promoting physical activity.
THE STUDY OF THERMAL DENATURATION OF BEEF, PORK, CHICKEN AND TURKEY MUSCLE PROTEINS USING DIFFERENTIAL SCANNING CALORIMETRY
Authors: Agafonkina Irina V. , Korolev Igor A. , Sarantsev Taras A. 
Published: October 2019

In the temperature range from 45 °C to 90 °C the process of thermal denaturation of a whole complex of muscle proteins in meat takes place. An effective mode to register the thermal denaturation process is the method of differential scanning calorimetry (DSC). As a result of studies the differences during the process of thermal denaturation of muscle proteins of pork, beef, chicken and turkey were defined by the appearance of endothermic peaks in DSC thermograms. The main variances are associated with the process of denaturation of myosin and sacroplasmic proteins and indicate indirectly their quantitative ratio in meat. The values of effective specific heat capacity in the temperature range from 20 °C to 90 °C are obtained as well as those of heat spent on the denaturation process.At reheating, the values of specific heat capacity increased by 0.1 J/(g*K) on the average, and peaks of thermal denaturation were not detected, that certifies the irreversibility of the denaturation process and the decrease in the bound moisture proportion in meat after thermal processing. Knowledge of the nature of protein thermal denaturation of each kind of meat product is one of the necessary tools for developing the technology of meat product thermal processing.
In Vitro Analysis of Protein:Protein Interactions in the Human Cancer-Pertinent rp.eL42-p53-Mdm2 Pathway
Authors: Aguida Blanche , Bouceba Tahar , Créchet Jean-Bernard , Hounguè Horrhus , Capo-Chichi Callinice , Nakayama Jun-ichi , Baouz Soria , Pelczar Hélène , Woisard Anne , Jourdan Nathalie , Hountondji Codjo 
Published: October 2019

Introduction:
We have recently demonstrated that the eukaryote-specific large subunit ribosomal protein
(rp) eL42 assists catalysis of peptide bond formation at the peptidyl transferase center of 80S
ribosomes in eukaryotic cells. Recently, several ribosomal proteins were shown to have extraribosomal
functions independent of protein biosynthesis. Such functions include regulation of
apoptosis, cell cycle arrest, cell proliferation, neoplastic transformation, cell migration and
invasion, and tumorigenesis through both Mdm2-p53-dependent and p53-independent
mechanisms. Our objective is to demonstrate that overexpression of eL42 in tumor may
incapacitate cell anti-tumor mechanism through interaction with the tumor suppressor protein
p53 and its partner Mdm2.

Methods:
Co-immunoprecipitation technique and the binding assays on Biacore were used to
probe interactions between recombinant eL42, p53 and Mdm2 proteins in a so-called rp-p53-Mdm2 axis.

Results:
We demonstrate that the ribosomal protein eL42, the tumor suppressor protein p53 and the ubiquitin E3 ligase Mdm2 interact with each other in a ternary rp.eL42:p53:Mdm2 complex. Precisely, the interaction between eL42 and p53 is characterized by a strong binding affinity (KD value in the nanomolar range) that is likely to trigger the sequestration of p53 and the inhibition of its tumor suppressor activity. Furthermore, the p53:Mdm2 and eL42:Mdm2 complexes exhibit comparable binding affinities in the micromolar range compatible with Mdm2 being the enzyme which ubiquitinates both the p53 and eL42 substrates. Interestingly, pyridoxal 5'-phosphate (PLP), one of the active forms of vitamin B6, binds to eL42 and significantly inhibits the interaction between eL42 and p53, in accordance with the observation that vitamin B6 is associated with reduced risk of cancer.

Conclusion:
Our study emphasized one more major mechanism of p53 downregulation involving its sequestration by eL42 upon the overexpression of this ribosomal protein. The mechanism described in the present report complemented the well-known p53 downregulation triggered by proteasomal degradation mediated through its ubiquitination by Mdm2.
Maternal Prenatal Anthropometry, High Education and Cesarean Delivery as Risk Factors for Low Gestational Age in Iran
Authors: Kheirouri Sorayya , Alizadeh Mohammad , Sarbakhsh Parvin 
Published: October 2019

Background:
Preterm birth is an important contributor to the global burden of disease. Evidence indicating that maternal health, nutritional and socioeconomic status may contribute to preterm birth.

Objective:
This cross-sectional study was conducted to describe the contribution of prenatal maternal factors on low gestational age, and to assess newborns anthropometric measurements regarding gestational age.

Methods:
Data of mothers delivering a singleton live infant (n= 759) and their newborns (n= 755) during the two years up to August 2014 were collected. Data were collected from the data set of eight public health centers which were chosen from different administrative regions of Tabriz city and were analyzed. Differences between the groups were assessed by Student’s t-test or one- way analysis of variance (ANOVA). Multiple linear regression was used to estimate the association between gestational age and variables studied.

Results:
Incidence of preterm birth was 2.1%. Percentage of infants with low birth weight and Head Circumference (HC) under 34 cm was significantly higher in the preterm group. Mean gestational age was lower in mothers with cesarean delivery, high education, high economic status, high BMI, pre-pregnancy weight ≥ 65 kg and medical problem. Gestational age was inversely associated with maternal pre-pregnancy weight ≥ 65 kg (B= -0.20, p= 0.02), high BMI (B= -0.33, p= 0.01), high education (B= -0.47, p= 0.002) and cesarean delivery (B= -0.74, p< 0.001).

Conclusion:
The results indicate that maternal anthropometric characteristics, education and type of delivery are associated with gestational age. Explorating potentially modifiable risk factors for unfavorable gestational age and integrating them into intervention efforts may ameliorate adverse birth outcomes.
The Influence of Social Media Lifestyle Interventions on Health Behaviour: A Study on Patients with Major Depressive Disorders and Family Caregivers
Authors: Jattamart A. , Leelasantitham A. 
Published: October 2019

Background:
The World Health Organisation (WHO) predicts that depression will be the second leading cause of diseases by 2020. If depression is not properly treated, it can develop into a depressive disorder and increase the risk of suicide.Besides biopsychosocial factors, lifestyle is said to be a major cause of this disease and has led to an increase in its prevalence.

Objective:
The objective of this study was to study the intentions of patients with major depressive disorders and family caregivers to change their health behaviour and lifestyle through social media influences.

Methods:
This was a cross-sectional study. Participants were invited to take part in the research and give their informed consent. The sample consisted of 157 patients diagnosed with major depressive disorders, aged 18 years and over, and 110 family caregivers. Data were collected from the questionnaires designed according to the I-Change Model (ICM). Statistical results to confirm causal relationships were analysed based on Structural Equation Modelling (SEM) and by using the SmartPLS 3 software.

Results:
Patients and family caregivers were questioned about their perspectives on health matters and the influence on their motivations and intentions to change patients’ health behaviour and lifestyle, particularly social media interventions. The patients received information and counselling about health matters, health awareness, motivation and their intentions to change their health behaviour. The family caregivers were presented with the same information and counselling to motivate them to influence the depressive patients’ intentions to change their health behaviour.

Conclusion:
It is possible that lifestyle interventions on social media can influence the intention to change health behaviour in both patients and caregivers. However, if the patient lacks interest in participating in the treatment and does not have a good relationship with the clinician or provide relevant information to the experts; this can be an obstacle to changing their health behaviour. Therefore, future research should be conducted to ascertain which interventions are appropriate for patients and to study the long-term effects of any risks from using social media in patients with major depressive disorders.
Ética tau y utopía en Aristóteles
Authors: Méndez Víctor Hugo 
Published: October 2019

“Ethos” and “ethos”, roots of the word “ethic”, are written with the consonant “theta” (Th). “Etos”, written with the consonant “tau” (T), means “year”. The aim of this paper is to highlight the presence of what I have called “tau ethic” in Greek political thought. To paraphrase Nietzsche, I perceive the birth of ethics out of the spirit of “ethos/ethos/etos”. To start with, Solon was one of the seven sages. Nobody could deny his influence in Archaic and Classical Greece. He was considered in those days a kind of founding father. His division of human life into periods of seven years was the canonical way of thinking about it in ancient times. In addition, Plato and Aristotle use to quote Solon as an indisputable authority. Finally, I show that Aristotle’s utopia is built on Solonian cornerstones. On the one hand, I emphasize the importance of Solonian anthropological thought in Aristotle’s Nicomachean Ethics and Politics. On the other hand, I show how ideal society is designed according to the age group into Aristotle´s utopia. To put the problem succinctly, an essential element of Aristotle’s practical philosophy is what I have called “tau ethic”, an issue not sufficiently researched.
¿Cuándo entra el alma al cuerpo?
Authors: Ortiz Millán Gustavo 
Published: October 2019

In this article I contrast the two traditional theories about the moment of the animation of the body, which serve as justification for the permissiveness of abortion. I analyze some of the metaphysical commitments of the idea of the soul and present some objections to the metaphysical framework that supports it. Although it is not possible to prove or disprove the existence of the soul, by an inference to the best explanation we should reject the idea and, therefore, claim that the soul does not enter the body at any time.
IMPLEMENTASI PEMBELAJARAN IPS BERBASIS KURIKULUM 2013 MELALUI LESSON STUDY DI SEKOLAH MUHAMMADIYAH KARTASURA
Authors: Subadi Tjipto , Priyono Kuswaji Dwi , Dahroni Dahroni , Musyiyam M. 
Published: October 2019

The purpose of this community service, assess and understand; 1) learning implementation strategy IPS (Social Sciences) Curriculum 2013 based on lesson study in the School of Muhammadiyah Kartasura. 2) Rationalization and elements of curriculum change in 2013. 3) The process of learning and assessment processes appropriate to the curriculum in 2013. The method used; workshops and training. The Place; SMK Muhammadiyah Kartasura. Execution time; odd semester 2014/2015. Subject: Elementary School teachers, Junior High School, High School and Vocational High School Muhammadiyah Kartasura. The results achieved; 1) learning implementation strategy IPS (Social Sciences) curriculum-based lesson study 203 through three stages, namely; plan (planning), do (action and observation), see (reflection). 2) Rationalization and elements of curriculum change in 2013 stressed on; a) The scientific approach is based approach to encourage student creativity; b)Integrity of the competence of knowledge, skills, and attitudes; c) Integrity of the curricular, co-curricular and extra-curricular activities. 3) The learning process is emphasized in the curriculum in 2013; (A) Integrated Thematic for elementary school level, (b) Approach Science (Natural Sciences) and IPS (Social Sciences) of partitive aggregative be integrated melt (liquid integrative), (c) religious and moral education, (d) learning objects; natural phenomena, social, and cultural arts. While the emphasisin the assessment process; assessment student achievement by using descriptive qualitative and quantitative numerical. Learning implementation strategy IPS (Social Sciences) 203 curriculum-based lesson study using a modified model of lesson study, achievement indicators for a significant increase from the prior worhshop and trainingafter the workshop, namely; 30%: 80% (pre-test: post-test).