bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of exposure to effervescent drugs in a large health check-up population in France: a cross-sectional study
Authors: Perrin Germain , Berdot Sarah , Thomas Frédérique , Pannier Bruno , Danchin Nicolas , Durieux Pierre , Sabatier Brigitte 
Published: July 2018

ObjectivesThe relationship between high dietary sodium intake and hypertension is well established. Some drugs are associated with high-sodium content, particularly effervescent tablets (ETs). Despite a possible cardiovascular risk associated with the use of such drugs, observational data describing exposure to ETs in ambulatory subjects are lacking.This study aims to estimate the prevalence of exposure to ETs and to highlight factors associated with this exposure in a large French health check-up population.DesignThis was a cross-sectional study.Setting and participantsParticipants were French individuals who underwent medical check-ups at the Investigations Préventives et Cliniques centre between April and June 2017.ResultsIn total, 1043 subjects were included in the study. The prevalence of exposure to ETs in the last 30 days was 26.9% (95% CI 24.2% to 29.6%). Exposure was frequent (ie, two ETs per week or more in the last 30 days) for 7.3% of subjects. Self-medication was the major source of exposure (93.8%). Paracetamol, aspirin, vitamins and betaine accounted for 95.3% of the ETs used. The factors associated with this exposure by multivariate analysis were: male gender, Overseas French origin, depression and body mass index ≥25 kg/m2. A diagnosis of hypertension or treatment with diuretics were not protective factors against exposure to ETs.ConclusionExposure to ETs is frequent in the general population, particularly through self-medication. Clinical conditions associated with low-salt requirements were not associated with lower exposure to ETs, suggesting a lack of awareness by practitioners and patients about this iatrogenic issue.
Binge drinking in young people: protocol for a systematic review of neuropsychological, neurophysiological and neuroimaging studies
Authors: Lees Briana , Mewton Louise , Stapinski Lexine , Squeglia Lindsay M , Rae Caroline , Teesson Maree 
Published: July 2018

IntroductionBinge drinking is the most common pattern of alcohol use among young people in Western countries. Adolescence and young adulthood is a vulnerable developmental period and binge drinking during this time has a higher potential for neurotoxicity and interference with ongoing neural and cognitive development. The purpose of this systematic review will be to assess and integrate evidence of the impact of binge drinking on cognition, brain structure and function in youth aged 10–24 years. Cross-sectional studies will synthesise the aberrations associated with binge drinking, while longitudinal studies will distinguish the cognitive and neural antecedents from the cognitive and neural effects that are a consequence of binge drinking.Methods and analysisA total of five peer-reviewed databases (PubMed, EMBASE, Medline, PsychINFO, ProQuest) will be systematically searched and the search period will include all studies published prior to 1 April 2018. The search terms will be a combination of MeSH keywords that are based on previous relevant reviews. Study selection will follow the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines and study quality will be assessed using The Grades of Recommendation, Assessment, Development and Evaluation approach. All studies will be screened against eligibility criteria designed to synthesise studies that examined a young binge drinking sample and used neuropsychological, neurophysiological or neuroimaging assessment techniques. Studies will be excluded if participants were significantly involved in other substances or if they had been clinically diagnosed with an alcohol use disorder, or any psychiatric, neurological or pharmacological condition. If available data permits, a meta-analysis will be conducted.Ethics and disseminationFormal ethics approval is not required as primary data will not be collected. The results will be disseminated through a peer-reviewed publication, conference presentations and social media.Trial registration numberInternational Prospective Register for Systematic Reviews (PROSPERO) number: CRD42018086856.
Unemployment, intragenerational social mobility and mortality in Finland: heterogeneity by age and economic context
Authors: Uggla Caroline , Billingsley Sunnee 
Published: July 2018

BackgroundWe explore how mortality is related to unemployment and intragenerational social mobility in Finland. Unemployment and social mobility are two labour market experiences that are largely studied separately, despite the fact that selection processes into unemployment and downward mobility are intertwined. Because both causal and health selection mechanisms may vary depending on the timing of these experiences, we consider heterogeneity by age and economic context.MethodsWe run discrete time event history analysis for death (at age 30–75 years) in two periods (economic recession and growth) and analyse younger and older individuals and men and women separately.ResultsThe odds of mortality were particularly high for individuals experiencing unemployment and when unemployment occurred during economic growth (OR ranging between 1.39 and 2.77). Younger men had high odds of mortality following unemployment (OR 1.86–2.77). In contrast, downward mobility was associated with higher odds of mortality only among older men and women and only during economic growth. The benefits of upward mobility were experienced mainly by younger men (OR ranging between 0.86 and 0.87) and were not experienced by women at all.ConclusionResults show that when in an individual’s life and the economic cycle unemployment and social mobility occur matters for whether these experiences are associated with mortality.
Whole-genome sequencing analysis of CNV using low-coverage and paired-end strategies is efficient and outperforms array-based CNV analysis
Authors: Zhou Bo , Ho Steve S , Zhang Xianglong , Pattni Reenal , Haraksingh Rajini R , Urban Alexander E 
Published: July 2018

BackgroundCopy number variation (CNV) analysis is an integral component of the study of human genomes in both research and clinical settings. Array-based CNV analysis is the current first-tier approach in clinical cytogenetics. Decreasing costs in high-throughput sequencing and cloud computing have opened doors for the development of sequencing-based CNV analysis pipelines with fast turnaround times. We carry out a systematic and quantitative comparative analysis for several low-coverage whole-genome sequencing (WGS) strategies to detect CNV in the human genome.MethodsWe compared the CNV detection capabilities of WGS strategies (short insert, 3 kb insert mate pair and 5 kb insert mate pair) each at 1×, 3× and 5× coverages relative to each other and to 17 currently used high-density oligonucleotide arrays. For benchmarking, we used a set of gold standard (GS) CNVs generated for the 1000 Genomes Project CEU subject NA12878.ResultsOverall, low-coverage WGS strategies detect drastically more GS CNVs compared with arrays and are accompanied with smaller percentages of CNV calls without validation. Furthermore, we show that WGS (at ≥1× coverage) is able to detect all seven GS deletion CNVs >100 kb in NA12878, whereas only one is detected by most arrays. Lastly, we show that the much larger 15 Mbp Cri du chat deletion can be readily detected with short-insert paired-end WGS at even just 1× coverage.ConclusionsCNV analysis using low-coverage WGS is efficient and outperforms the array-based analysis that is currently used for clinical cytogenetics.
Marx and Critical Theory
Authors: Renault Emmanuel 
Published: July 2018

AbstractMarx and Critical Theoryexamines Marx’s main philosophical, political and social theoretical ideas. Its purpose is twofold: making sense of the concepts and theses of Marx, and showing that they remain relevant for contemporary critical theory. Part 1 focuses on Marx’s conception of philosophy. Part 2 analyses the Marxian primacy of the practical. Part 3 is devoted toCapitaland the critique of political economy. This book will be useful for those who want to deepen their understanding of Marx’s main ideas, as well as for those who want to clarify what is at stake in contemporary debates about the ways in which contemporary critical theory could or should refer to Marx.
Effects of the Submesoscale on the Potential Vorticity Budget of Ocean Mode Waters
Authors: Wenegrat Jacob O. , Thomas Leif N. , Gula Jonathan , McWilliams James C. 
Published: July 2018

AbstractNonconservative processes change the potential vorticity (PV) of the upper ocean and, later, through the subduction of surface waters into the interior, affect the general ocean circulation. Here we focus on how boundary layer turbulence, in the presence of submesoscale horizontal buoyancy gradients, generates a source of potential vorticity at the ocean surface through a balance known as the turbulent thermal wind. This source of PV injection at the submesoscale can be of similar magnitude to PV fluxes from the wind and surface buoyancy fluxes, and hence can lead to a net injection of PV onto outcropped isopycnals even during periods of surface buoyancy loss. The significance of these dynamics is illustrated using a high-resolution realistic model of the North Atlantic Subtropical Mode Water (Eighteen Degree Water), where it is demonstrated that injection of PV at the submesoscale reduces the rate of mode water PV removal by a factor of ~2 and shortens the annual period of mode water formation by ~3 weeks, relative to air–sea fluxes alone. Submesoscale processes thus provide a direct link between small-scale boundary layer turbulence and the gyre-scale circulation, through their effect on mode water formation, with implications for understanding the variability and biogeochemical properties of ocean mode waters globally.
Performance Evaluation of the Fast Spherical Harmonic Transform Algorithm in the Yin–He Global Spectral Model
Authors: Yin Fukang , Wu Guoli , Wu Jianping , Zhao Jun , Song Junqiang 
Published: July 2018

Abstract
In this paper, we describe an implementation of the fast spherical harmonic transform (SHT) algorithm in the Yin–He global spectral model (YHGSM). A new analysis method is proposed to study the potential instability of interpolative decomposition and to evaluate the performance of fast SHT on the MilkyWay-2 supercomputer. The novel aspect of the proposed method is the use of the computational complexity analysis method by studying the properties of interpolative decompositions. Furthermore, three test cases are conducted to verify fast SHT in YHGSM. The results demonstrate that fast SHT is feasible and efficient for reducing the computational complexity and memory cost of SHT while still keeping enough accuracy.
Early Indication of Noise-Induced Hearing Loss in Young Adult Users of Personal Listening Devices
Authors: Hussain Timon , Chou Carol , Zettner Erika , Torre Peter , Hans Stefan , Gauer Johannes , Markgraf Marius , Nguyen Quyen T. 
Published: July 2018

Objectives: The recent integration of portable music players into cell phones has further increased the use of personal listening devices (PLD) among young adults, raising concerns about potentially hazardous effects on hearing. Methods: Assessment of young adults’ hearing ability and listening preferences by subjective and objective measurement. Young adult users of PLDs (n = 50; 30 females, 20 males; mean age = 24.1 ± 4.2 years; average PLD use = 6.1 ± 2.1 years) were included. Subjective assessment of listening preferences was performed via a questionnaire as well as objective assessment of preferred volume levels in different background noise environments and hearing tests. Results: Preferred volume levels were significantly correlated with hearing thresholds. Most participants exhibited safe listening behavior according to National Institute for Occupational Safety and Health criteria. We identified a substantial high-risk subgroup of PLD users (22% of participants, daily use ⩾2 h at ⩾91 dB) in which pure tone audiometry showed increased hearing thresholds at 4000 and 6000 Hz, potentially indicating an early manifestation of noise-induced hearing loss (NIHL). Conclusions: These findings suggest that preventive measures may be warranted to prevent a future increase of clinically relevant NIHL among heavy users of PLDs.
The combination of cerebrospinal fluid procalcitonin, lactate, interleukin-8 and interleukin-10 concentrations for the diagnosis of postneurosurgical bacterial meningitis: A prospective study
Authors: Zhang Guojun , Yang Chunjiao , Kang Xixiong , Gao Zhixian , Wan Hong , Liu Yunpeng 
Published: July 2018

Background The differential diagnosis between postneurosurgical bacterial meningitis and aseptic meningitis remains challenging both for the clinician and the laboratory. Combinations of markers, as opposed to single ones, may improve diagnosis and thereby survival. Methods This prospective cohort study included patients with suspected bacterial meningitis after neurosurgery. The patients were divided into two groups according to the diagnostic criteria of meningitis involving a postneurosurgical bacterial meningitis group and a postneurosurgical aseptic meningitis group. Four biomarkers, including cerebrospinal fluid procalcitonin, lactate, interleukin-8 and interleukin-10 were assayed separately, and three algorithms were constructed using a linear combination. The area under the receiver operating characteristic curve was used to compare their performances. Results A cohort of 112 patients was enrolled in our study. Forty-three patients were diagnosed with postneurosurgical bacterial meningitis, and the cerebrospinal fluid values of their biomarkers were higher in patients with postneurosurgical bacterial meningitis than with postneurosurgical aseptic meningitis. The area under the receiver operating characteristic curves for the detection of postneurosurgical bacterial meningitis were 0.803 (95% confidence interval [CI], 0.724–0.883) for procalcitonin; 0.936 (95% CI, 0.895–0.977) for lactate; 0.771 (95% CI, 0.683–0.860) for interleukin-8; 0.860 (95% CI, 0.797–0.929) for interleukin-10; 0.937 (95% CI, 0.897–0.977) for the composite two-marker test; 0.945 (95% CI, 0.908–0.982) for the composite three-marker test and 0.954 (95% CI, 0.922–0.989) for the composite of all tests. The area under the receiver operating characteristic curves of the combination tests were greater than those of the single markers. Conclusions Combining information from several markers improved the diagnostic accuracy in detecting postneurosurgical bacterial meningitis.
The effect of therapeutic phlebotomy for hemochromatosis on non-suicidal self-injury: A case report
Authors: Newham Benjamin JC , Khanna Rahul 
Published: July 2018

Background Self-phlebotomy has been described as a form of non-suicidal self-injury. However, a relationship between non-suicidal self-injury and therapeutic phlebotomy for hemochromatosis has not previously been described. Case presentation: We present a case of a 52-year-old man in whom the frequency of his therapeutic phlebotomy and non-suicidal self-injury were inversely linked, leading to adverse outcomes when his phlebotomy was suspended. Conclusions This is the first report describing the relationship between non-suicidal self-injury and therapeutic phlebotomy. This case highlights the need for risk assessment and monitoring of self-harm in patients who are undergoing therapeutic phlebotomy in order to prevent adverse outcomes.
Early integrated palliative approach for idiopathic pulmonary fibrosis: A narrative study of bereaved caregivers’ experiences
Authors: Pooler Charlotte , Richman-Eisenstat Janice , Kalluri Meena 
Published: July 2018

Background: Idiopathic pulmonary fibrosis has an uncertain and rapid trajectory after diagnosis. Palliative care is rarely utilized, although both patients and caregivers experience a distressingly high symptom burden. Most patients die in hospital. Aim: The purpose of this study was to explore bereaved caregivers’ experiences and perceptions of an early integrated palliative approach implemented at a Multidisciplinary Interstitial Lung Disease Clinic. Design: A narrative approach was used, with thematic and content analysis of open-ended interviews. Setting/participants: The clinic is located in a large western Canadian city. Caregivers of deceased patients were recruited through purposive sampling. The eight participants were either spouses or adult children. Results: Five major themes were identified: Having a Terminal Disease; Planning Goals and Wishes for Care; Living Life and Creating Memories; Feeling Strain and Responsibility; and Nearing the End. Caregivers had little understanding of prognosis prior to advance care planning conversations at the clinic. Advance care planning conversations enabled caregivers to know and support patients’ goals and wishes. Caregivers described feeling informed, prepared, and supported when death was near. They expressed neither distress nor anxiety related to patients’ symptoms or strain of relationships. Conclusion: Collaboration and close communication among caregivers, respirologists, and home care enabled effective symptom management and out of hospital deaths. Patients and caregivers had opportunities to enjoy events, create memories, determine preferences, and make plans. Further research on an early integrated palliative approach in Idiopathic Pulmonary Fibrosis is warranted related to quality of life, experience with death and dying, and caregiver bereavement.
Esophageal Adenocarcinoma: Opportunities for Targeted Prevention in Ohio
Authors: Stephens Julie A , Fisher James L , Krok-Schoen Jessica L , Baltic Ryan D , Sobotka Holly L , Paskett Electra D 
Published: July 2018

Objective: The incidence of esophageal adenocarcinoma, one of the most lethal gastroenterological diseases, has been increasing since the 1960s. Prevention of esophageal adenocarcinoma is important because no early detection screening programs have been shown to reduce mortality. Obesity, gastroesophageal reflux disease, and tobacco smoking are risk factors for esophageal adenocarcinoma. Due to the high prevalence in Ohio of obesity (32.6%) and cigarette smoking (21.0%), this study sought to identify trends and patterns of these risk factors and esophageal adenocarcinoma in Ohio as compared with the United States. Methods: Data from the Ohio Cancer Incidence Surveillance System, Surveillance Epidemiology and End Results Program (SEER), and Behavioral Risk Factor Surveillance System were used. Incidence rates overall, by demographics and by county, as well as trends in incidence of esophageal adenocarcinoma and the percent of esophageal adenocarcinoma among esophageal cancers were examined. Trends in obesity and cigarette smoking in Ohio, and the prevalence of each by county, were reported. Results: There was an increasing trend in esophageal adenocarcinoma incidence in Ohio. Ohio’s average annual esophageal adenocarcinoma incidence rate was higher than the SEER rate overall and for each sex, race, and age group in 2009 to 2013. There was also an increasing prevalence of obesity in Ohio. Although the prevalence of cigarette smoking has been stable, it was high in Ohio compared with the United States. Conclusions: Health care providers and researchers should be aware of the esophageal adenocarcinoma incidence rates and risk factor patterns and tailor interventions for areas and populations at higher risk.
Plasma-Free Amino Acid Profiles in Crohn’s Disease: Relationship With the Crohn Disease Activity Index
Authors: Chiba Toshimi , Suzuki Kazuyuki , Matsumoto Takayuki 
Published: July 2018

We aimed to clarify the relationship between plasma-free amino acid (PFAA) profiles and the Crohn’s disease (CD) activity index (CDAI) in patients with CD. Methods: We measured fasting PFAA concentrations in 29 patients with CD and their correlation with disease activity. Results: In all patients, significant correlations were noted between CDAI and concentrations of valine, methionine, leucine, histidine, tryptophan, alanine, tyrosine, total amino acids (TAAs), nonessential amino acids (NEAAs), essential amino acids (EAAs), and branched-chain amino acids (BCAAs). In patients with the ileo-colonic type of CD, significant correlations were noted between CDAI and valine, histidine, tryptophan, glutamine, TAA, NEAA, EAA, and BCAA. In ileal type, significant correlations were observed between CDAI and threonine, valine, histidine, serine, and glycine. In colonic type, significant correlations were noted between CDAI and valine, histidine, tryptophan, TAA, NEAA, EAA, and BCAA. Conclusions: In patients with CD, plasma amino acids appear to be associated with disease activity.
Case report and systematic review of pulmonary embolism mimicking ST-elevation myocardial infarction
Authors: Villablanca Pedro A , Vlismas Peter P , Aleksandrovich Tatsiana , Omondi Arthur , Gupta Tanush , Briceno David F , Garcia Mario J , Wiley Jose 
Published: July 2018

Background To study trends in the clinical presentation, electrocardiograms, and diagnostic imaging in patients with pulmonary embolism presenting as ST segment elevation. Methods We performed a systematic literature search for all reported cases of pulmonary embolism mimicking ST-elevation myocardial infarction. Pre-specified data such as clinical presentation, electrocardiogram changes, transthoracic echocardiographic findings, cardiac biomarkers, diagnostic imaging, therapy, and outcomes were collected. Results We identified a total of 34 case reports. There were 23 males. Mean age of the population was 56.5 ± 15.5 years. Patients presented with dyspnea (76.4%), chest pain (63.6%), and tachycardia (71.4%). All patients presented with ST-elevations, with the most common location being in the anterior-septal distribution, lead V3 (74%), V2 (71%), V1 (62%) and V4 (47%). ST-segment elevations in the inferior distribution were present in lead II (12%), III (18%), and aVF (21%). Presentation was least likely in the lateral distribution. Troponin was elevated in 78.9% of cases. Right ventricular strain was the most common echocardiographic finding. Over 80% of patients had findings consistent with elevated right ventricular pressure, with 50% reported RV dilatation and 20% RV hypokinesis. The most commonly used imaging modality was contrast-enhanced pulmonary angiography. There was a greater incidence of bilateral compared to unilateral pulmonary emboli (72.4% vs. 10%). About 65% patients received anticoagulation and 36.3% were treated with thrombolytics. Forty-six percent of patients required intensive care and 18.7% intubation. Overall mortality was 25.8%. Conclusions A review of the literature reveals that in patients presenting with pulmonary embolism, electrocardiogram findings of ST-segment elevations will occur predominantly in the anterior-septal distribution.