bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prevalence and prognostic value of D‐dimer elevation in patients with AL amyloidosis
Authors: Pudusseri Anita , Sanchorawala Vaishali , Sloan J. Mark , Bever Katherine M. , Doros Gheorghe , Kataria Shivangi , Sarosiek Shayna 
Published: July 2019

AbstractLight chain (AL) amyloidosis is a protein folding disorder that can affect many different organ systems, in addition to the coagulation pathway. D‐dimer, a measurement of fibrin degradation, is commonly elevated in hematologic malignancies, but the prevalence and significance of D‐dimer elevation in AL amyloidosis is unknown. We conducted an analysis of 921 patients with AL amyloidosis that presented to the Boston University Amyloidosis Center. Baseline characteristics and laboratory data of the 897 patients included in the final cohort were analyzed. Four hundred twenty three patients (47%) had an elevated D‐dimer (>0.5 μg/mL). Multivariate analysis demonstrated that a normal D‐dimer level of ≤0.5 μg/mL, and a level of >0.5 μg/mL but <1 μg/mL, conferred a lower risk of mortality (HR 0.49 and 0.59, respectively) when compared to a D‐dimer level ≥ 1 μg/mL. The increased risk of mortality in patients with a D‐dimer level ≥ 1 μg/mL was present in all cardiac stages. The median overall survival based on D‐dimer range of ≤0.5, >0.5 but <1, and ≥ 1 μg/mL was 5.86, 4.04, and 2.08 years, respectively (P < .001). This retrospective analysis demonstrates the high prevalence of D‐dimer elevation in AL amyloidosis and confirms that this laboratory finding is independently associated with decreased survival.
Body frame size, body image, self‐esteem, and health‐related quality of life in schoolchildren
Authors: Guzmán de la Garza Francisco J. , Salinas‐Martínez Ana M. , Zendejas‐Valdéz Juan M. , Cordero‐Franco Hid F. , Mathiew‐Quirós Álvaro , de la Garza‐Salinas Laura H. 
Published: July 2019

AbstractObjectiveThe aim of this study was to explore the relationship between body frame size (BFS) and body image, self‐esteem, and health‐related quality of life (HRQL) in Mexican schoolchildren.MethodsThis cross‐sectional study included children aged 6 to 11 years. Body image, self‐esteem, and HRQL were evaluated through interviews. Two frame‐size measures, biacromial and bitrochanteric diameters, were collected and summed for categorizing BFS as small, medium, or large. Height and weight were also measured. Spearman's correlations were determined and adjusted by sex, age, and body mass index (BMI). Multiple logistic regression analyses were performed with the psychological measure as the binary dependent variable, the categories of BFS as the independent variable, and sex, age, and BMI as control variables.ResultsThe correlation between BFS and body image was 0.15 (P < .01) and after BMI adjustment was 0.07 (P > .05). BFS did not correlate with self‐esteem nor HRQL (P > .05). Of the children, 79% were dissatisfied with their body image, 20% had a low self‐esteem, and 31.8% had a poorly perceived HRQL; there were no differences by BFS. The multivariate analysis showed that a large BFS was not associated with body image dissatisfaction (OR 1.2, 95% CI 0.6‐2.3), low self‐esteem (OR 1.3, 95% CI 0.7‐2.6), or poor HRQL (OR 1.3, 95% CI 0.8‐2.2).ConclusionsBFS was not correlated with body image, self‐esteem, or HRQL. A high self‐esteem and a good level of HRQL prevailed, but a high proportion of children were dissatisfied with their body image. School interventions should promote an appropriate body image and a healthy lifestyle.
Expanding phenotype with severe midline brain anomalies and missense variant supports a causal role for FOXA2 in 20p11.2 deletion syndrome
Authors: Dines Jennifer N. , Liu Yajuan J. , Neufeld‐Kaiser Whitney , Sawyer Taylor , Ishak Gisele E. , Tully Hannah M. , Racobaldo Melissa , Sanchez‐Valle Amarilis , Disteche Christine M. , Juusola Jane , Torti Erin , McWalter Kirsty , Doherty Dan , Dipple Katrina M. 
Published: July 2019

AbstractRare individuals with 20p11.2 proximal deletions have been previously reported, with a variable phenotype that includes heterotaxy, biliary atresia, midline brain defects associated with panhypopituitarism, intellectual disability, scoliosis, and seizures. Deletions have ranged in size from 277 kb to 11.96 Mb. We describe a newborn with a de novo 2.7 Mb deletion of 20p11.22p11.21 that partially overlaps previously reported deletions and encompasses FOXA2. Her clinical findings further expand the 20p11.2 deletion phenotype to include severe midline cranial and intracranial defects such as aqueductal stenosis with hydrocephalus, mesencephalosynapsis with diencephalic‐mesencephalic junction dysplasia, and pyriform aperture stenosis. We also report one individual with a missense variant in FOXA2 who had abnormal glucose homeostasis, panhypopituitarism, and endodermal organ dysfunction. Together, these findings support the critical role of FOXA2 in panhypopituitarism and midline defects.
Descriptive and risk factor analysis of nonsyndromic sacral agenesis: National Birth Defects Prevention Study, 1997–2011
Authors: Nalbandyan Marine , Howley Meredith M. , Cunniff Christopher M. , Romitti Paul A. , Browne Marilyn L. ,   for the National Birth Defects Prevention Study
Published: July 2019

AbstractSacral agenesis is a rare birth defect characterized by partial or complete absence of the sacrum. We sought to (a) describe case characteristics, (b) estimate birth prevalence, and (c) identify risk factors for nonsyndromic sacral agenesis using data from the National Birth Defects Prevention Study (NBDPS). The NBDPS was a population‐based, case–control study involving pregnancies with estimated dates of delivery from October 1997 through December 2011. We estimated birth prevalence using all NBDPS eligible cases. Using self‐reported maternal exposure information, we conducted multivariable logistic regression analysis to identify potential risk factors overall and among women without diabetes. The birth prevalence of sacral agenesis was 2.6/100,000 live births. In the multivariable analysis, multifetal pregnancy, pre‐existing Type 1 diabetes, and pre‐existing Type 2 diabetes were positively and significantly associated with sacral agenesis, albeit estimates were imprecise. Preexisting Type 1 diabetes was the strongest risk factor (adjusted odds ratio = 96.6, 95% confidence interval = 43.5–214.7). Among women without diabetes, periconceptional smoking was positively and significantly associated with sacral agenesis. Our findings underscore the importance of smoking cessation programs among women planning pregnancy and the importance of better understanding the role of glycemic control before and during pregnancy when designing interventions for primary prevention of sacral agenesis.
A Tandem Ring‐Opening/Michael Addition/Ring‐Closure Sequence for the Regiospecific Synthesis of 5‐Hydroxy‐4,5‐dihydroisoxazoles
Authors: Wang Xuesong , Chen Yu , Chen Xin , Zhang Xueying , Guan Weiwei , Li Youbin 
Published: July 2019

AbstractAn effective and highly regiospecific strategy for the synthesis of 5‐hydroxy‐4,5‐dihydroisoxazoles is described via a tandem reaction including ring‐opening, Michael addition, and ring‐closure in one pot under mild conditions. Diverse structural 5‐hydroxy‐4,5‐dihydroisoxazoles were afforded in up to 96% yield for 21 examples. This strategy is highly efficient, environmentally friendly, and metal free.
Characterization of innovative sensors for volatile organic compounds trace compounds in biogas
Authors: Franchi Giovanni , Zollo Sharon , Pennazza Giorgio , Santonico Marco , Capocelli Mauro , Di Paola Luisa , Piemonte Vincenzo 
Published: July 2019

AbstractThe production of biogas requires the development of cheap and effective inline monitoring of 11 systems; specifically, pure biogas for specialized applications (solid oxide fuel cells) needs 12 very low concentrations of volatile organic compounds' contaminants. In this work, we report an application of a system, Bionote, already tested at very low concentrations (ppb) for biomedical applications. In details, we applied a gas sensors array of functionalized transducers to the detection of three target analytes (methanol, acetone, and isoprene) to high concentrations of analytes (up to 10,000 ppm). The results were widely satisfactory, because they demonstrate in this range the applicability of the system, which is largely reversible as well. The low cost and very low response times of these sensors stimulate in the direction of their full development and application for online monitoring of biogas in production processes.
Microfibrillated‐cellulose‐reinforced polyester nanocomposites prepared by filtration and hot pressing: Bending properties and three‐dimensional formability
Authors: Ishikura Yukiko , Yano Hiroyuki 
Published: July 2019

ABSTRACTThe microfibrillated cellulose (MFC)–polyester fiber nanocomposites were prepared by dispersing various amounts of MFC with polyester fibers in water, followed by filtration, mold compression, drying, and hot pressing. Further, bending tests and dynamic mechanical analysis (DMA) of the hot‐pressed nanocomposites were performed, and the three‐dimensional (3D) formability of the samples subjected to hot pressing was investigated. With more than 50 wt% MFC content, the bending strength and elastic modulus of the materials substantially increased. Furthermore, the DMA results revealed that, with increasing MFC content, the decrease in the material storage modulus with increasing temperature became less pronounced. Results indicate that the MFC network formation increased in materials with increasing MFC content. The 3D formation was also possible in all the samples, and an increase in sample expansion and decrease in the spring‐back of shapes with increasing moisture content were observed with an increase in the polyester fiber content in the materials. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2020, 137, 48192.
Optimizing size and distribution of voids in phenolic resins through the choice of catalyst types
Authors: Hamad Sameer F. , Farr Nicholas , Fei Teng , Shukor Nur F. , Dean Julian S. , Hayes Simon A. , Foreman Joel P. , Rodenburg Cornelia 
Published: July 2019

ABSTRACTPhenolics are widely used for over a century in different industries due to their chemical resistance and thermomechanical properties. However, the presence of voids in phenolic resins has negative effects on the mechanical properties and a conventional approach is to avoid these by utilizing very long cure cycles. Our alternative approach investigates the tailoring of void size and distribution to achieve a better balance between processing time and mechanical properties. Therefore, we produced phenolic resin with a void‐free microstructure by a long cure cycle as a reference. To alter the void size and distributions, we utilized different catalysts and a short cure cycle to obtain phenolic resins and test their flexural properties with respect to the reference. We investigated the fracture surfaces of all materials by SEM, FTIR and compared results to finite element modeling that confirmed the effects of different void size and distributions on the mechanical properties. © 2019 The Authors. Journal of Applied Polymer Science published by Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 48249.
Pharmacokinetic modeling of the blood‐stable camptothecin analog AR‐67 in two different formulations
Authors: Liu Xiaoxi , Adane Eyob , Tang Fei , Leggas Markos 
Published: July 2019

AbstractAR‐67 is a lipophilic camptothecin analog currently under clinical investigation using a Cremophor EL based formulation. However, as potential toxicity limitations exist in the clinical use of Cremophor, an alternative cyclodextrin (SBE‐β‐CD) based formulation has been proposed. Pharmacokinetic (PK) studies were conducted in mice and the SBE‐β‐CD based formulation was compared with the Cremophor EL formulation. PK studies were conducted following intravenous or oral administration of AR‐67 in either Cremophor or SBE‐β‐CD formulation in mice. Noncompartmental analysis was used to determine the plasma and tissue drug distribution. A non‐linear mixed effects (population) PK model was developed to fit both the oral and intravenous data and to estimate key PK parameters. The effect of formulation was explored as a covariate in the PK model. AR‐67 in the SBE‐β‐CD formulation had similar plasma PK and biodistribution to that in the Cremophor EL formulation. The proposed two‐compartment model described the plasma PK of AR‐67 in both formulations adequately. AR‐67 in the SBE‐β‐CD formulation exhibited dose linearity following both oral and intravenous administration. Our studies indicate that SBE‐β‐CD is a viable alternative to Cremophor EL as a pharmaceutical excipient for formulating AR‐67.
How a maximizing orientation affects trade‐offs between desirability and feasibility: The role of outcome‐ versus process‐focused decision making
Authors: Hsieh Meng‐Hua , Yalch Richard F. 
Published: July 2019

AbstractThis research examines how maximizers make decisions when they must trade‐off between desirability and feasibility attributes. Across four studies, we demonstrate that maximizers tend to prefer choices offering more desirability to those offering more feasibility and respond more favorably to a product's advertising when it highlights desirability more than feasibility attributes. Furthermore, we show that maximizers' focus on outcomes rather than processes drives their preference for desirability, such that changing from an outcome to a process focus can redirect their interest from desirability to feasibility. By contrast, satisficers do not prefer products higher in desirability to those higher in feasibility and are not more receptive to ads highlighting desirability attributes. Furthermore, because satisficers may focus on both the outcome and the process, priming either one is redundant and does not alter their preference for desirability or feasibility.
Clinicopathological features and prognostic validity of the European Neuroendocrine Tumor Society (ENETS) and American Joint Committee on Cancer (AJCC) 8th staging systems in colonic neuroendocrine neoplasms
Authors: Zhang Yu , Shang Liang , Zhang Pan‐Pan , Chen Luo‐Hai , Wang Wei , Fang Cheng , Qiu Meng , Feng Xing‐Yu , Zhou Lin , Zhang Meng , Tan Huang‐Ying , Qiu Xu‐Dong , Wang Hao , Lin Rong , Zhang Qin , Zeng Yu‐Jie , Jin Kai‐Zhou , Yu Xian‐Jun , Shen Lin , Chen Min‐Hu , Li Jie , Li Le‐Ping , Chen Jie 
Published: July 2019

AbstractPurposeThis study aimed to investigate the characteristics of colonic neuroendocrine neoplasms (NENs) and to validate the prognostic value of the European Neuroendocrine Tumor Society (ENETS) and American Joint Committee on Cancer (AJCC) 8th staging systems.MethodsA total of 167 and 1248 patients with colonic NENs from 12 medical centers across China and from the Surveillance, Epidemiology, and End Results (SEER) cancer registry in the United States, respectively, were reviewed. Patients were staged according to the ENETS and AJCC 8th staging systems.ResultsClinicopathological features of colonic NENs in the Chinese cohort and SEER cohort were significantly distinct. In both the Chinese cohort and the SEER cohort, colonic neuroendocrine carcinoma (NEC) and mixed adeno‐neuroendocrine carcinoma (MANEC) were more frequent in the midgut than in the hindgut. Tumors originating from the midgut tended to be larger and at a more advanced stage than those from the hindgut. The AJCC 8th staging system and the ENETS system appeared to have similar prognostic ability for colonic NEC/MANEC.ConclusionsOur study revealed that tumors originating from the midgut and the hindgut shared different clinicopathological features. The AJCC 8th staging system and the ENETS system appeared to have similar prognostic ability for colonic NEC/MANEC.
The Transferability of Family Assessment Tools between Countries: Reflections on the Intervention Research Approach
Authors: Strydom Marianne , Schiller Ulene 
Published: July 2019

This paper illustrates the practical implementation of intervention research when adapting a family assessment tool between countries. Developing countries such as South Africa are emphasising the indigenisation of practices to ensure applicable theories and practices when addressing unique societal contexts or challenges. New social work technology can be developed using the process of intervention research. This paper analyses the application of intervention research using the social constructionism paradigm in addressing the research problem of how a family assessment tool can be transferred from one country to another, with the main focus being on feedback and the application of this method by the researchers. Forty‐six social workers were trained in the use of the assessment tool, and feedback on the adaptation of the tool was gathered during focus group discussions on various occasions. Results indicate the importance of contextualising the tool within the context of specific countries to ensure relevancy and applicability, especially among different racial and cultural groups, as well as to ensure that the relevant stakeholders are consulted in the development of new technology. Intervention research ensures a rigorous research process to adapt existing technology to a local context.‘This paper illustrates the practical implementation of intervention research when adapting a family assessment tool between countries’Key Practitioner Messages

Intervention research is an appropriate approach in adapting tools from one context to another.
Focus group discussion enhances the ability of practitioners to jointly construct practice realities.
The applicability of assessment tools is enhanced by widely consulting with practitioners.
Transcatheter mitral valve‐in‐valve implantation in a pediatric patient
Authors: Momenah Tarek S. , Alsahari Atif , Ahmed Eltayeb , Al Khalaf Khalaf 
Published: July 2019

AbstractAn 11‐year‐old girl, with 25 mm mosaic tissue valve presented with clinical and echocardiographic appearance of stenotic mitral valve prosthesis. Her condition was treated via a transcatheter valve‐in‐valve implantation using a 23 mm Edwards Sapien 3, with satisfactory outcome.
H2O2 Tolerance in Pseudomonas Fluorescens: Synergy between Pyoverdine‐Iron(III) Complex and a Blue Extracellular Product Revealed by a Nanotechnology‐Based Electrochemical Approach
Authors: Magro Massimiliano , Baratella Davide , Jakubec Petr , Corraducci Vittorino , Fasolato Luca , Cardazzo Barbara , Novelli Enrico , Zoppellaro Giorgio , Zboril Radek , Vianello Fabio 
Published: July 2019

AbstractSome strains of Pseudomonas fluorescens generate a blue extracellular product conferring high resistance to oxidative stress with respect to white mutants. As conventional methods fail to discriminate among blue and white microorganisms, the mechanism of H2O2 scavenging activity of colored P. fluorescens was here investigated by an electrochemical approach coupled to nanotechnology. Hydrophilic pyoverdine, the most represented siderophore, was studied as possible electrocatalytic partner of the hydrophobic blue bacterial extract. Peculiar iron oxide nanoparticles were used as a support for the siderophore immobilization, mimicking a water soluble FeIII‐siderophore complex. Interestingly, even if these two counterparts are not redox active when used alone, the siderophore was able to trigger the crude colored bacterial extract into a selective catalyst for hydrogen peroxide elimination. The present study, besides shedding light into the bacterial mechanisms behind the tolerance to H2O2, highlights the advantages of using nanotechnology as complement of classical electrochemical methods aimed at addressing complex biological issues.
Differentiation of stabilized nitrocellulose during artificial aging: Spectroscopy methods coupled with principal component analysis
Authors: Trache Djalal , Tarchoun Ahmed Fouzi 
Published: July 2019

AbstractIn this work, Fourier transform infrared spectroscopy (FTIR) and X‐ray powder diffraction (XRD) were selected as reliable, fast, and nondestructive techniques to assess their potentialities for characterization and discrimination of nitrocellulose (NC)‐based formulations containing different kinds of stabilizers and subjected to accelerated aging. Preliminary results based on visual comparison of the spectra point out that spectra obtained by both spectroscopic techniques were useful for a rapid detection of the aging process without additional sample preparation. Additionally, the existence of compatibility issues between NC and one of the stabilizers is easily recognized. The spectral data were subjected to principal component analysis (PCA) for visualization and to reveal differences between samples. The obtained results demonstrated that PCA plots were able to distinguish and classify the NC samples with respect to their respective stabilizers and aging.
Bidirectional association between aortic dissection and atrial fibrillation: Findings from a huge national database
Authors: Hu Wei‐Syun , Lin Cheng‐Li 
Published: July 2019

AbstractObjectiveTo explore the link between aortic dissection (AD) and atrial fibrillation (AF).MethodsUsing the National Health Insurance Research Database (NHIRD), cohorts were constructed for evaluating the incidence of AF in patients with AD (study 1) and the incident AD among AF patients (study 2) based on propensity matching analysis. Cox proportion hazard regression models were used to examine the effect of AD on the risk of AF, shown as hazard ratios (HRs) with 95% confidence intervals (CIs). Similar statistical procedures were used for study 2.ResultsThe study 1 consisted of 11 813 patients in the AD cohort and 11 813 controls in the non‐AD cohort and the study 2 consisted of 190 494 patients in the AF cohort and 190 494 controls in the non‐AF cohort. The overall incidence density of AF was 1.32‐fold higher in the AD cohort than in the non‐AD cohort (11.1 and 8.3 per 1000 person‐years), with an adjusted HR (aHR) of 1.74 (95% CI = 1.53‐1.98). The AF cohort had 1.18‐fold higher incidence of AD than the non‐AF cohort (0.55 vs 0.47 per 1000 person‐years), with an aHR of 1.24 (95% CI = 1.07‐1.44).ConclusionsBidirectional association between AD and AF was shown for the first time in this study.
Tuning the Dimensionality of Nano Ca(OH)2 with Surfactants for Wall Painting Consolidation
Authors: Zhu Jinmeng , Li Xuanhua , Yan Jing , Zhao Xichen , Cao Yijian , Camaiti Mara , Li Tong , Wei Bingqing 
Published: July 2019

AbstractAs an effective conservation material for wall paintings, ancient paper, and stone artifacts, nano Ca(OH)2 has been studied for more than two decades. However, the synthesis methods are expensive, complex, time‐consuming, or require considerable energy. To tackle the issue, we report, in this study, a facile, large‐scale, time saving, and economical method for synthesizing nano Ca(OH)2 (∼90 nm) at room temperature. This is achieved by controlling crystal growth of Ca(OH)2 at the (
) facet (vertical direction) and (0001) facet (horizontal direction) with simultaneous addition of octyl phenyl polyoxyethylene ether (OPPE) and dimethylformamide (DMF) in the reaction. Density functional theory (DFT) calculations revealed that the crystal dimensionality tuning is caused by attaching OPPE to the (0001) facet and DMF to the (
) facet of Ca(OH)2. Experimental results showed that the synthesized nano Ca(OH)2 has higher stability and carbonation degree than commercial Ca(OH)2 and was used for consolidating a 1300‐year‐old tomb painting, which is a very important, precious, and heavily damaged national treasure of China. The results demonstrate that the nano Ca(OH)2 shows excellent penetration into the painting, considerably improves the strength of the painting, and has no side effects on the color, pore distribution, and porosity of the painting. Our work will significantly facilitate the industrial production of nano Ca(OH)2 and its application in cultural heritage conservation.