bluuebunny/crossref_metadata_2025_split huggingface dataset:
Supportive Coparenting, Parenting Stress, Harsh Parenting, and Child Behavior Problems in Nonmarital Families
Authors: Choi Jeong‐Kyun , Becher Emily H. 
Published: June 2018

Supportive coparenting is an identified protective factor for child development and behavioral outcomes. What is less known is how supportive coparenting dynamically links with other aspects of parenting and parent well‐being, particularly in multi‐stressed nonmarital families. This study used data from the Fragile Families and Child Wellbeing study, analyzed within a structural equation model, to explore how mothers’ experience of maternal depression, maternal age, father education, andSESinteracted with their parenting stress and supportive coparenting to impact child behavioral problems and harsh parenting practices. Among the findings, more supportive coparenting was found to be significantly associated with fewer child behavioral problems and less harsh parenting. Transmitted through supportive coparenting and parenting stress acting as mediator, maternal depressive symptoms were indirectly and positively related to harsh parenting practices and child behavior problems. These findings are discussed within the context of the broader literature and next steps for research are discussed.
Acceptance, Psychiatric Symptoms, and Migraine Disability: An Observational Study in a Headache Center
Authors: Seng Elizabeth K. , Kuka Alexander J. , Mayson Sarah Jo , Smitherman Todd A. , Buse Dawn C. 
Published: June 2018

ObjectiveTo evaluate relationships between psychiatric symptoms, acceptance, and migraine‐related disability in a sample of people with migraine presenting at a tertiary care headache center.BackgroundMigraine is a chronic disease that can be severely disabling. Despite a strong theoretical basis and evidence in other pain conditions, little is known about relationships between acceptance, psychiatric symptoms, and migraine‐related disability.MethodsNinety patients with physician‐diagnosed migraine completed surveys assessing demographics, headache symptoms, severe migraine‐related disability (Migraine Disability Assessment Scale total score dichotomized at ≥ 21), depression (Patient Health Questionnaire‐9) and anxiety symptoms (Generalized Anxiety Disorder‐7), and acceptance (Chronic Pain Acceptance Questionnaire; subscales: Pain Willingness and Activity Engagement).ResultsParticipants (77.8% white, non‐Hispanic; 85.6% women; and 50.0% with a graduate level education) reported an average headache pain intensity of 6.7/10 (SD = 2.0). One‐third (36.0%) reported chronic migraine, and half (51.5%) reported severe migraine‐related disability. Lower acceptance was associated with severe migraine‐related disability, t(54) = 4.13, P < .001. Higher activity engagement was associated with lower average headache pain intensity (r = −.30, P = .011). Higher acceptance was associated with lower levels of depression (r = −.48, P < .001) and anxiety symptoms (r = −.37, P = .003). Pain willingness and activity engagement serially mediated relationships between depression symptoms and severe migraine‐related disability (indirect effect = 0.05, 95% CI = 0.01, 0.15), and between anxiety symptoms and severe migraine‐related disability (indirect effect = 0.12, 95% CI = 0.02, 0.31).ConclusionResults provided preliminary support for a theoretical pathway by which psychiatric symptoms may influence migraine‐related disability, in part, through their relationships with pain willingness and activity engagement.
The “three‐in‐one” formulation of bismuth quadruple therapy for Helicobacter pylori eradication with or without probiotics supplementation: Efficacy and safety in daily clinical practice
Authors: Zagari Rocco Maurizio , Romiti Alessandra , Ierardi Enzo , Gravina Antonietta G. , Panarese Alba , Grande Giuseppe , Savarino Edoardo , Maconi Giovanni , Stasi Elisa , Eusebi Leonardo Henry , Farinati Fabio , Conigliaro Rita , Bazzoli Franco , Romano Marco 
Published: June 2018

AbstractBackgroundClinical trials have shown a good efficacy of the “three‐in‐one” formulation of bismuth quadruple therapy (BQT) for Helicobacter (H.) pylori eradication. We aimed to assess the efficacy and safety of the three‐in‐one BQT in clinical practice, and investigate the effect of probiotic supplementation, in Italy.Materials and MethodsA retrospective database, multicentre observational study was conducted in seven Italian Hospitals. Consecutive H. pylori‐positive patients who received the three‐in‐one BQT for 10 days were included in the analysis. H. pylori eradication was assessed by histology, 13C‐urea breath test, or stool antigen test. Compliance and adverse events were evaluated by interview.ResultsA total of 376 patients were included in the intention‐to‐treat (ITT) and 352 in the per protocol (PP) analyses. One hundred and ninety‐three subjects received probiotics supplementation. Overall, eradication rates were 90.2% (95% Confidence Interval (CI):86.7‐93.0) in ITT and 94.6% (95% CI: 91.7‐96.7) in PP analyses. The compliance was good (≥90% of treatment taken) in 94.9% of patients. The proportion of patients with a good compliance was not different with and without probiotics supplementation (94.8% vs 95.1%). Eradication rates were equally high for first‐line (91.4%), second‐line (87.5%), and third‐line treatments (91.7%) in the ITT analysis (P = .48). Adverse events were reported by 32.4% of patients, but only 6.1% of patients discontinued treatment.ConclusionsThe three‐in‐one BQT is highly effective and well tolerated for H. pylori eradication in daily clinical practice. Probiotics supplementation fails to improve compliance.
Spermine oxidase is upregulated and promotes tumor growth in hepatocellular carcinoma
Authors: Hu Tingting , Sun Dalong , Zhang Jie , Xue Ruyi , Janssen Harry L.A. , Tang Wenqing , Dong Ling 
Published: June 2018

AimThe polyamine catabolic enzyme, spermine oxidase (SMOX) is upregulated in chronic inflammatory conditions and linked to increased reactive oxygen species and DNA damage in various forms of cancers. The present study aims to explore the expression pattern and biological function of SMOX in hepatocellular carcinoma (HCC).MethodsWe used quantitative real‐time polymerase chain reaction, Western blotting, and immunohistochemistry to examine SMOX expression in four HCC cell lines and 120 HCC clinical samples, and the clinical significance of SMOX was analyzed. The biological function of SMOX on HCC cells was detected both in vitro and in vivo.ResultsResults showed that SMOX was overexpressed in HCC cell lines and clinical HCC tissues. Moreover, SMOX expression levels were gradually increased in normal liver, chronic hepatitis, and HCC tissues. Increased SMOX expression was correlated with poor clinical features of HCC. Patients with positive SMOX expression in tumor tissues indicated worse overall survival (P = 0.008) and shorter relapse‐free survival (P = 0.002). Knockdown of SMOX inhibited HCC cell proliferation, arrested cell cycle at S phase, and resulted in an increase of apoptosis. The in vivo study showed that inhibition of SMOX in HCC cells significantly repressed tumor growth in nude mice. Furthermore, we showed that SMOX might exert its function by regulating the phosphatidylinositol 3′‐kinase/protein kinase B signaling pathway.ConclusionOur data indicated that SMOX upregulation could be a critical oncogene in HCC and might serve as a valuable prognostic marker and potential therapeutic target for HCC.
Towards elimination of HIV transmission, AIDS and HIV‐related deaths in the UK
Authors: Brown AE , Nash S , Connor N , Kirwan PD , Ogaz D , Croxford S , De Angelis D , Delpech VC 
Published: June 2018

ObjectivesOur objective was to present recent trends in the UK HIV epidemic (2007–2016) and the public health response.MethodsHIV diagnoses and clinical markers were extracted from the HIV and AIDS Reporting System; HIV testing data in sexual health services (SHS) were taken from GUMCAD STI Surveillance System. HIV data were modelled to estimate the incidence in men who have sex with men (MSM) and post‐migration HIV acquisition in heterosexuals. Office for National Statistics (ONS) data enabled mortality rates to be calculated.ResultsNew HIV diagnoses have declined in heterosexuals as a result of decreasing numbers of migrants from high HIV prevalence countries entering the UK. Among MSM, the number of HIV diagnoses fell from 3570 in 2015 to 2810 in 2016 (and from 1554 to 1096 in London). Preceding the decline in HIV diagnoses, modelled estimates indicate that transmission began to fall in 2012, from 2800 [credible interval (CrI) 2300–3200] to 1700 (CrI 900–2700) in 2016. The crude mortality rate among people promptly diagnosed with HIV infection was comparable to that in the general population (1.22 vs. 1.39 per 1000 aged 15–59 years, respectively). The number of MSM tested for HIV at SHS increased annually; 28% of MSM who were tested in 2016 had been tested in the preceding year. In 2016, 76% of people started antiretroviral therapy within 90 days of diagnosis (33% in 2007).ConclusionsThe dual successes of the HIV transmission decline in MSM and reduced mortality are attributable to frequent HIV testing and prompt treatment (combination prevention). Progress towards the elimination of HIV transmission, AIDS and HIV‐related deaths could be achieved if combination prevention, including pre‐exposure prophylaxis, is replicated for all populations.
Psoriasis: implication to disease and therapeutic strategies, with an emphasis on drug delivery approaches
Authors: Todke Pooja , Shah Viral H. 
Published: June 2018

AbstractSkin is the most visible and vulnerable organ of the integumentary system. Psoriasis is a chronic inflammatory skin disorder with an equal prevalence rate in males and females globally. Psoriasis is seen today beyond a cosmetic turmoil as it significantly impacts the socioeconomic life of the patients. Patients with severe psoriasis report feeling denounced and isolated. Despite detailed understanding of the molecular mechanisms and pathogenesis of psoriasis, issues like the autoimmune cause of inflammation and role of external, genetic, cutaneous, and systemic factors on initiation, progression, and treatment of psoriasis are still ambiguous. The present review summarizes immunogenic pathophysiology of psoriasis with a cascade of events from stimuli‐based release of self‐nucleotides to the hyperproliferation of keratinocytes leading to psoriasis. The review emphasizes challenges and hurdles toward the efficient treatment of psoriasis. The review also provides a detailed understanding of conventional and novel treatment strategies including drug delivery approaches and patented technologies for therapeutic and preventive approaches leading to improved outcome for psoriasis patients. The review summarizes a brief insight on biologics and gene therapy that has resulted in a paradigm shift in the treatment strategies for psoriasis management.
One‐seller assignment markets with multi‐unit demands: Core and competitive equilibrium
Authors: Robles Francisco , Núñez Marina 
Published: June 2018

AbstractWe consider an assignment market with one seller who owns several indivisible heterogeneous goods and many buyers each willing to buy up to a given capacity. In this market, the core contains the Vickrey payoff vector. However, core allocations may not be supported by competitive equilibrium prices, even in a finite replication of the market. We first characterize the convexity of the associated coalitional game and we show that it is a sufficient condition so that the buyers‐optimal core allocation is competitive. With respect to the seller‐optimal core allocation, we provide a characterization of competitiveness by means of buyers’ valuations. In addition, we characterize in terms of the valuation matrix the coincidence between the core and the set of competitive equilibrium payoff vectors.
Standardization and comparison of nonautomated assays to measure the collagen binding activity of von Willebrand factor
Authors: Oliveira L. M. M. , Amorim M. V. A. , Corsini C. A. , Neto C. C. A. , Chaves D. G. 
Published: June 2018

AbstractIntroductionDiagnosis of von Willebrand disease (VWD) is difficult due to the heterogenic phenotype of patients and to the complex tests that are required for an adequate investigation. The collagen binding assay (VWF:CB) reveals the adhesion capacity of von Willebrand factor (VWF) to collagen and can be useful to reduce the misleading diagnosis ofVWD. This study aimed the standardization of 2 nonautomatedVWF:CBassays based onELISAand flow cytometry.MethodsPlasma samples from 87 patients previously diagnosed withVWDand 22 healthy controls were analyzed. Measurement of theVWF‐collagen binding activity was performed using a commercial assay and the 2 tests proposed.VWF:CB/VWF:Ag ratio was calculated for samples and the differentiation between types 1, 2A, and 2M was analyzed.ResultsELISAand flow cytometry tests presented strong correlation with the gold standard test (r2 = .8976 andr2 = .8143, respectively). Tests based onELISAand flow cytometry presented a bias of +7.2% and −3.6%, respectively.ConclusionTheELISAtest demonstrated better performance to detectVWF‐collagen binding activity in healthy individuals andVWDpatients. This test could differentiate 2A and 2M subtypes using a feasible protocol that can be easily implemented.
Yonsei nomogram: A predictive model of new‐onset chronic kidney disease after on‐clamp partial nephrectomy in patients with T1 renal tumors
Authors: Abdel Raheem Ali , Shin Tae Young , Chang Ki Don , Santok Glen Denmer R , Alenzi Mohamed Jayed , Yoon Young Eun , Ham Won Sik , Han Woong Kyu , Choi Young Deuk , Rha Koon Ho 
Published: June 2018

ObjectivesTo develop a predictive nomogram for chronic kidney disease‐free survival probability in the long term after partial nephrectomy.MethodsA retrospective analysis was carried out of 698 patients with T1 renal tumors undergoing partial nephrectomy at a tertiary academic institution. A multivariable Cox regression analysis was carried out based on parameters proven to have an impact on postoperative renal function. Patients with incomplete data, <12 months follow up and preoperative chronic kidney disease stage III or greater were excluded. The study end‐points were to identify independent risk factors for new‐onset chronic kidney disease development, as well as to construct a predictive model for chronic kidney disease‐free survival probability after partial nephrectomy.ResultsThe median age was 52 years, median tumor size was 2.5 cm and mean warm ischemia time was 28 min. A total of 91 patients (13.1%) developed new‐onset chronic kidney disease at a median follow up of 60 months. The chronic kidney disease‐free survival rates at 1, 3, 5 and 10 year were 97.1%, 94.4%, 85.3% and 70.6%, respectively. On multivariable Cox regression analysis, age (1.041, P = 0.001), male sex (hazard ratio 1.653, P < 0.001), diabetes mellitus (hazard ratio 1.921, P = 0.046), tumor size (hazard ratio 1.331, P < 0.001) and preoperative estimated glomerular filtration rate (hazard ratio 0.937, P < 0.001) were independent predictors for new‐onset chronic kidney disease. The C‐index for chronic kidney disease‐free survival was 0.853 (95% confidence interval 0.815–0.895).ConclusionWe developed a novel nomogram for predicting the 5‐year chronic kidney disease‐free survival probability after on‐clamp partial nephrectomy. This model might have an important role in partial nephrectomy decision‐making and follow‐up plan after surgery. External validation of our nomogram in a larger cohort of patients should be considered.
Clinical correlates of severe thrombocytopenia from temozolomide in glioblastoma patients
Authors: Arulananda Surein , Lynam James , Sem Liew Mun , Wada Morikatsu , Cher Lawrence , Gan Hui K. 
Published: June 2018

AbstractBackground/AimThis study was conducted retrospectively to evaluate rates of thrombocytopenia and their clinical impact during chemo‐radiotherapy for glioblastomas and to elucidate associated clinical factors.MethodsA total of 64 patients who received temozolomide chemotherapy at our institution was included; 35 patients received full‐dose chemo‐radiotherapy as per the STUPP protocol (Group A), and 9 patients received abbreviated radiotherapy with concurrent chemotherapy (Group B). Twenty patients received temozolomide alone with an intended 12 cycles of therapy for first relapse at least 6 months after completion of adjuvant chemotherapy (Group C).ResultsIn Group A, 27 of 35 (77%) patients completed the chemo‐radiotherapy phase; 14% had grade 3–4 thrombocytopenia leading to discontinuation. Of 27 patients, 16 (59%) completed adjuvant chemotherapy. There were no grade 3–4 thrombocytopenias, but 4% discontinued due to grade 2 thrombocytopenias. In Group B, four of nine (45%) patients completed the chemo‐radiotherapy phase; 11% had grade 3–4 thrombocytopenias and discontinued treatment. Three of four (75%) patients completed adjuvant chemotherapy. Of these, 75% had grade 3–4 thrombocytopenias, but none discontinued. Finally, in Group C, 8 of 20 (40%) patients completed, with 10% discontinuing due to thrombocytopenias and the rest due to disease progression. In exploratory analyses, being female increased the risk of myelosuppresion, and there was a trend noticed in patients having a higher body surface area.ConclusionOur toxicity data were within range of the literature. We identified the group of patients that have increased thrombocytopenia risk. Larger pooled retrospective series and prospective studies are required.
Male reproductive system of the arrow crab Stenorhynchus seticornis (Inachoididae)
Authors: Antunes Mariana , Zara Fernando J. , López Greco Laura S. , Negreiros‐Fransozo Maria L. 
Published: June 2018

AbstractOur aim was to describe the reproductive system of males and the formation of sperm packages in the seminal receptacle (SR) of recently mated females of the arrow crab Stenorhynchus seticornis. The male reproductive system was analyzed, and was described using light microscopy and histological and histochemical methods. The first pair of gonopods was described by means of scanning electron microscopy. Additionally, the dehiscence of spermatophores was tested using samples obtained from the vas deferens of males and from the seminal receptacle of recently mated females. Testes were tubular type, and each vas deferens consisted of three regions: the anterior vas deferens (AVD), including a proximal portion that was filled with free spermatozoa and a distal portion contained developing spermatophores; the median vas deferens (MVD) that contained completely formed spermatophores; and the posterior vas deferens (PVD), which contained only granular secretions. The accessory gland, which was filled with secretions, was located in the transition region between the MVD and the PVD. The spermatophores from the MVD were of different sizes, and none of them showed dehiscence in seawater, whereas those spermatophores in contact with the seminal receptacle were immediately broken. The ultrastructure of the gonopods revealed the presence of denticles at the distal portion, which contribute to the mechanical rupture of the spermatophore wall during the transfer of sperm. The contents of the PVD and accessory gland of males are transferred together with the spermatophores, and are responsible for the secretions observed among the sperm packets in the SR of the female. We suggest that these secretions formed the layers found in the SR of recently mated females, and may play a role in sperm competition in arrow crabs.
Altered perception‐action binding modulates inhibitory control in Gilles de la Tourette syndrome
Authors: Petruo Vanessa , Bodmer Benjamin , Brandt Valerie C. , Baumung Leoni , Roessner Veit , Münchau Alexander , Beste Christian 
Published: June 2018

BackgroundGilles de la Tourette Syndrome (GTS) is a multifaceted neuropsychiatric developmental disorder with onset in childhood or adolescence and frequent remissions in early adulthood. A rather new emerging concept of this syndrome suggests that it is a disorder of purposeful actions, in which sensory processes and their relation to motor responses (actions) play a particularly important role. Thus, this syndrome might be conceived as a condition of altered ‘perception‐action binding’. In the current study, we test this novel concept in the context of inhibitory control.MethodsWe examined N = 35 adolescent GTS patients and N = 39 healthy controls in a Go/Nogo‐task manipulating the complexity of sensory information triggering identical actions; i.e. to inhibit a motor response. This was combined with event‐related potential recordings, EEG data decomposition and source localization.ResultsGTS patients showed worse performance compared to controls and larger performance differences when inhibitory control had to be exerted using unimodal visual compared to bimodal auditory‐visual stimuli. This suggests increased binding between bimodal stimuli and responses leading to increased costs of switching between responses instructed by bimodal and those instructed by unimodal stimuli. The neurophysiological data showed that this was related to mechanisms mediating between stimulus evaluation and response selection; i.e. perception‐action binding processes in the right inferior parietal cortex (BA40).ConclusionsStimulus‐action inhibition binding is stronger in GTS patients than healthy controls and affects inhibitory control corroborating the concept suggesting that GTS might be a condition of altered perception‐action integration (binding); i.e. a disorder of purposeful actions.
Effects of sodium–glucose cotransporter 2 inhibitors in addition to insulin therapy on cardiovascular risk factors in type 2 diabetes patients: A meta‐analysis of randomized controlled trials
Authors: Wu Bingshu , Zheng Hongzhi , Gu Jianqiu , Guo Yan , Liu Yixuan , Wang Yingfang , Chen Feng , Yang Aolin , Wang Jiabei , Wang Hailong , Liu Ying , Wang Difei 
Published: June 2018

AbstractAims/IntroductionIn the present meta‐analysis, we aimed to determine the effects of sodium–glucose cotransporter 2 inhibitor (SGLT‐2i) in addition to insulin therapy on cardiovascular risk factors in type 2 diabetes patients.Materials and MethodsRandomized controlled trials were identified by searching the PubMed, Embase and Cochrane Library databases published before September 2017. The intervention group received SGLT‐2i as add‐on treatment to insulin therapy, and the control group received placebos in addition to insulin. We assessed pooled data, including weighted mean differences and 95% confidence intervals (CIs) using a random‐effects model.ResultsA total of 10 randomized controlled trials (n = 5,159) were eligible. The weighted mean differences for systolic blood pressure and diastolic blood pressure were −3.17 mmHg (95% CI −4.53, −1.80, I2 = 0%) and −1.60 mmHg (95% CI −2.52, −0.69, I2 = 0%) in the intervention groups. Glycosylated hemoglobin, fasting plasma glucose, postprandial glucose and daily insulin were also lower in the intervention groups, with relative weighted mean differences of −0.49% (95% CI −0.71, −0.28%, I2 = 92%), −1.10 mmol/L (95% CI −1.69, −0.51 mmol/L, I2 = 84%), −3.63 mmol/L (95% CI −4.36, −2.89, I2 = 0%) and −5.42 IU/day (95% CI −8.12, −2.72, I2 = 93%). The transformations of uric acid and bodyweight were −26.16 μmol/L (95% CI −42.14, −10.17, I2 = 80%) and −2.13 kg (95% CI −2.66, −1.60, I2 = 83%). The relative risk of hypoglycemia was 1.09 (95% CI 1.02, 1.17, P < 0.01). The relative risks of urinary tract and genital infection were 1.29 (95% CI 1.03, 1.62, P = 0.03) and 5.25 (95% CI 3.55, 7.74, P < 0.01).ConclusionsThe results showed that in the intervention group, greater reductions were achieved for blood pressure, glucose control, uric acid and bodyweight. This treatment regimen might therefore provide beneficial effects on the occurrence and development of cardiovascular events.