bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dynamic Supramolecular Ruthenium‐Based Gels Responsive to Visible/NIR Light and Heat
Authors: Teasdale Ian , Theis Sabrina , Iturmendi Aitziber , Strobel Moritz , Hild Sabine , Jacak Jaroslaw , Mayrhofer Philipp , Monkowius Uwe 
Published: June 2019

AbstractA simple supramolecular crosslinked gel is reported with a photosensitive ruthenium bipyridine complex functioning as a crosslinker and poly(4‐vinylpyridine) (P4VP) as a macromolecular ligand. Irradiation of the organogels in H2O/MeOH with visible and NIR light (in a multiphoton process) leads to cleavage of pyridine moieties from the ruthenium complex breaking the cross‐links and causing degelation and hence solubilization of the P4VP chains. Real‐time (RT) photorheology experiments of thin films showed a rapid degelation in several seconds, whereas larger bulk samples could also be photocleaved. Furthermore, the gels could be reformed or healed by simple heating of the system and restoration of the metal–ligand crosslinks. The relatively simple dynamic system with a high sensitivity towards light in the visible and NIR region make them interesting positive photoresists for nano/micropatterning applications, as was demonstrated by writing, erasing, and rewriting of the gels by single‐ and multiphoton lithography.
Enantioselective ene‐reduction of E‐2‐cyano‐3‐(furan‐2‐yl) acrylamide by marine and terrestrial fungi and absolute configuration of (R)‐2‐cyano‐3‐(furan‐2‐yl) propanamide determined by calculations of electronic circular dichroism (ECD) spectra
Authors: Jimenez David E.Q. , Barreiro Juliana C. , dos Santos Fernando M. , de Vasconcellos Suzan P. , Porto André L.M. , Batista João M. 
Published: June 2019

AbstractThis work reports the green organic chemistry synthesis of E‐2‐cyano‐3(furan‐2‐yl) acrylamide under microwave radiation (55 W), as well as the use of filamentous marine and terrestrial‐derived fungi, in the first ene‐reduction of 2‐cyano‐3‐(furan‐2‐yl) acrylamide to (R)‐2‐cyano‐3‐(furan‐2‐yl)propanamide. The fungal strains screened included Penicillium citrinum CBMAI 1186, Trichoderma sp. CBMAI 932 and Aspergillus sydowii CBMAI 935, and the filamentous terrestrial fungi Aspergillus sp. FPZSP 146 and Aspergillus sp. FPZSP 152. A compound with an uncommon CN‐bearing stereogenic center at the α‐C position was obtained by enantioselective reactions mediated in the presence of the microorganisms yielding the (R)‐2‐cyano‐3‐(furan‐2‐yl) propanamide 3a. Its isolated yield and e.e. ranged from 86% to 98% and 39% to 99%, respectively. The absolute configuration of the biotransformation products was determined by time‐dependent density functional theory (TD‐DFT) calculations of electronic circular dichroism (ECD) spectra. Finally, the tautomerization of 2‐cyano‐3‐(furan‐2‐yl) propanamide 3a to form an achiral ketenimine was observed and investigated in presence of protic solvents.
Comparing optimal and heuristic taskgraph scheduling on parallel machines with frequency scaling
Authors: Eitschberger Patrick , Keller Jörg 
Published: June 2019

SummaryWe investigate static scheduling of taskgraphs onto parallel machines where the frequency of processors can be scaled at runtime. Given a deadline until which execution of the resulting schedule must be completed, we aim at minimizing the energy consumed by the parallel processors during execution. We present optimal and heuristic solutions to this problem and partial problems. We quantify the increase in energy consumption when switching from a globally optimal solution via a combination of optimal partial solutions to heuristic solutions. We find that, on our set of benchmark taskgraphs, the increase is 32.56% on average for a combination of heuristic solutions and thus tolerable.
Biofilm formation on polyetheretherketone and titanium surfaces
Authors: Barkarmo Sargon , Longhorn Daniel , Leer Kiran , Johansson Carina B. , Stenport Victoria , Franco‐Tabares Sebastian , Kuehne Sarah A. , Sammons Rachel 
Published: June 2019

AbstractObjectivePolyetheretherketone (PEEK) is a polymer used in devices in orthopedic and dental rehabilitation. The aim of this in vitro study was to compare biofilm formation by a range of important oral bacterial species on PEEK, blasted PEEK, commercially pure titanium (cp‐Ti), and titanium‐6 aluminium‐4 vanadium (Ti6Al4V).Material and methodsCoin‐shaped samples were manufactured, and the surfaces were characterized using optical interferometry, scanning electron microscopy, energy‐dispersive X‐ray spectroscopy, and contact angle measurements. Bacterial species of Streptococcus sanguinis, Streptococcus oralis, Enterococcus faecalis, and Streptococcus gordonii were cultured on the four material surfaces for varying amounts of time. Biofilms were quantified following staining with crystal violet.ResultsRoughness and contact angle results showed blasted PEEK > PEEK > cp‐Ti = Ti6Al4V. There was increased biofilm formation on blasted PEEK by S. sanguinis, S. oralis, and S. gordonii, whereas the bacterial adhesion was similar on PEEK, cp‐Ti, and Ti6Al4V. The bacterial growth of E. faecalis was significantly higher on cp‐Ti compared with the other three groups.ConclusionThe results, taking into consideration the biofilm formation, suggest that PEEK should perform as well as cp‐Ti or TiAl6V4 when used as a dental restorative material.
Improving green product development performance from green vision and organizational culture perspectives
Authors: Chen Yu‐Shan , Lin Shu‐Hsien , Lin Chun‐Yu , Hung Shu‐Tzu , Chang Chih‐Wei , Huang Ching‐Wen 
Published: June 2019

AbstractThe main purpose of this study is to how to enhance the green product development performance from the perspectives of green vision and organizational culture. This study explores the influences of a green shared vision and the environmental organizational culture on the green product development performance in Taiwan's manufacturing industry. It also examines the mediation effect of the green absorptive capacity. The empirical results indicate that both the green shared vision and environmental organizational culture have positive effects on the green absorptive capacity, which in turn positively affects the green product development performance. In particular, the green absorptive capacity completely mediates the relationship between the green shared vision and green product development performance, whereas it partially mediates the relationship between the environmental organizational culture and green product development performance.
Novel analogs of sulfasalazine as system xc− antiporter inhibitors: Insights from the molecular modeling studies
Authors: Patel Dhavalkumar , Kharkar Prashant S. , Gandhi Neha S. , Kaur Ekjot , Dutt Shilpee , Nandave Mukesh 
Published: June 2019

AbstractSystem xc− (Sxc−), a cystine‐glutamate antiporter, is established as an interesting target for the treatment of several pathologies including epileptic seizures, glioma, neurodegenerative diseases, and multiple sclerosis. Erastin, sorafenib, and sulfasalazine (SSZ) are a few of the established inhibitors of Sxc−. However, its pharmacological inhibition with novel and potent agents is still very much required due to potential issues, for example, potency, bioavailability, and blood–brain barrier (BBB) permeability, with the current lead molecules such as SSZ. Therefore, in this study, we report the synthesis and structure–activity relationships (SAR) of SSZ derivatives along with molecular docking and dynamics simulations using the developed homology model of xCT chain of Sxc− antiporter. The generated homology model attempted to address the limitations of previously reported comparative protein models, thereby increasing the confidence in the computational modeling studies. The main objective of the present study was to derive a suitable lead structure from SSZ eliminating its potential issues for the treatment of glioblastoma multiforme (GBM), a deadly and malignant grade IV astrocytoma. The designed compounds with favorable Sxc− inhibitory activity following in vitro Sxc− inhibition studies, showed moderately potent cytotoxicity in patient‐derived human glioblastoma cells, thereby generating potential interest in these compounds. The xCT‐ligand model can be further optimized in search of potent lead molecules for novel drug discovery and development studies.
Enhanced cognitive behavioral therapy for adolescents with anorexia nervosa: Outcomes and predictors of change in a real‐world setting
Authors: Dalle Grave Riccardo , Sartirana Massimiliano , Calugi Simona 
Published: June 2019

AbstractObjectiveThe study aimed to establish the outcomes and predictors of change in a cohort of adolescents with anorexia nervosa treated via enhanced cognitive behavioral therapy (CBT‐E) in a real‐world clinical setting.MethodForty‐nine adolescent patients with anorexia nervosa were recruited from consecutive referrals to a clinical eating disorder service offering outpatient CBT‐E. Body Mass Index centiles and Eating Disorder Examination Questionnaire, Brief Symptom Inventory, and Clinical Impairment Assessment scores were recorded at admission, at the end of treatment, and at 20‐week follow‐up.ResultsThirty‐five patients (71.4%) who finished the program showed both considerable weight gain and reduced scores for clinical impairment and eating disorder and general psychopathology. Changes remained stable at 20 weeks. No baseline predictors of drop‐out or treatment outcomes were detected.ConclusionsBased on these results, CBT‐E seems suitable for adolescent patients with anorexia nervosa seeking treatment in a real‐world clinical setting.
Positive roadside edge effects on artificial nest survival in a lowland Atlantic Forest
Authors: da Silva Gleidson Ramos , Diniz Pedro , Banhos Aureo , Duca Charles 
Published: June 2019

AbstractRoad construction is considered to be one of the primary causes of forest fragmentation, and little is known about how roads affect bird reproductive success. The objective of this study was to assess the survival rate of artificial nests along an edge associated with a highway and in the interior of a tabuleiro forest. The study was performed at the Sooretama Biological Reserve, on the margins of federal highway BR‐101, between September and October 2015. A total of 168 artificial nests with a Common quail (Coturnix coturnix) egg in each nest were placed along six sampling transects, at distances of 2, 25, 50, 100, 200, 400, and 800 m from the highway toward the forest interior. We used logistic regression and estimated daily survival rate (DSR) using the “Nest Survival” function in the program MARK to estimate artificial nest survival and assessed the effect of the distance from the highway. The artificial nest survival rate was significantly higher on the highway margins than at other distances. The results show that artificial nests located up to 25 m from the highway have a greater success probability (over 95%) and a significant decrease in success probability more than 50 m from the highway. Although we cannot rule out other nonroad‐specific edge effects on artificial nest predation, our results suggest that the impacts of the highway (e.g., noise, vibration, visual stimuli) cause predators to avoid the road's surroundings (up to 25 m into the forest) when selecting their feeding sites, which partially supports the predation release hypothesis.
High‐resolution melting of the cytochrome B gene in fecal DNA: A powerful approach for fox species identification of the Lycalopex genus in Chile
Authors: Anabalón Leonardo , Encina‐Montoya Francisco , Sánchez Pamela , Solano Jaime , Benavente Felipe , Guiñez Basilio , Olivares Flavio , Oberti Carlos , Vega Rolando 
Published: June 2019

AbstractEasy, economic, precise species authentication is currently necessary in many areas of research and diagnosis in molecular biology applied to conservation studies of endangered species. Here, we present a new method for the identification of three fox species of the Lycalopex genus in Chile. We developed an assay based on high‐resolution melt analysis of the mitochondrial cytochrome B gene, allowing a simple, low cost, fast, and accurate species determination. To validate the assay applicability for noninvasive samples, we collected fecal samples in the Atacama Desert, finding unexpectedly one species outside of its known distribution range. We conclude that the assay has a potential to become a valuable tool for a standardized genetic monitoring of the Lycalopex species in Chile.
On consensus in multiagent systems with quantized signal communication
Authors: Furusaka Takumi , Sato Takao , Araki Nozomu , Konishi Yasuo 
Published: June 2019

AbstractIn this paper, we consider the consensus control of multiagent systems with quantized signal communication. In such a network system, when the static quantizer is used, the control performance is degraded because of the influence of the quantization error. To compensate the quantization error, in a conventional method, a probabilistic quantizer is used. On the other hand, in this paper, the dynamic quantizer is introduced instead of the static quantizer. Because the dynamic quantizer is optimally designed, the control performance of the proposed method can be improved better than the conventional methods. Finally, the effectiveness of the proposed method is demonstrated through numerical examples.
Blood urea nitrogen variation upon admission and at discharge in patients with heart failure
Authors: Khoury Johad , Bahouth Fadel , Stabholz Yoav , Elias Adi , Mashiach Tanya , Aronson Doron , Azzam Zaher S. 
Published: June 2019

AbstractAimsHeart failure (HF) is one of the leading causes for hospitalization and mortality. After first admission with acute decompensated HF, some patients are in high risk for short‐term and long‐term mortality. These patients should be identified, closely followed up, and treated. It has been observed that blood urea nitrogen (BUN) on admission is a predictive marker for short‐term mortality. Recently, it has been shown that higher BUN levels on discharge are also a bad prognostic predictor. However, the prognostic value of BUN alteration during hospital stay was not investigated; therefore, we aimed to investigate the effect of BUN variation during hospitalization on mortality.Methods and resultsA retrospective study included patients with first hospitalization with the primary diagnosis of HF. The patients were divided into four groups on the basis of the values of BUN on admission and discharge, respectively: normal‐normal, elevated‐normal, normal‐elevated, and elevated‐elevated. Four thousand seven hundred sixty‐eight patients were included; 2567 were male (53.8%); the mean age was 74.7 ± 12.7 years. The 90 day mortality rate in the normal‐normal group was 7% lower than that in the elevated‐normal (14.6%) and normal‐elevated (19.3%) groups; P value < 0.01. The 90 day mortality in the elevated‐elevated group (28.8%) was significantly higher than that in the other groups; P < 0.001. During the 36 month follow‐up, these results are maintained. While sub‐dividing BUN levels into <30, 30–39, and >40 mg/dL, higher BUN levels correlated with higher 90 day mortality rate regardless of creatinine levels, brain natriuretic peptide, or age. Moreover, BUN on admission and on discharge correlated better with mortality than did creatinine and glomerular filtration rate at the same points.ConclusionsThe BUN both on admission and on discharge is a prognostic predictor in patients with HF; however, patients with elevated levels both on admission and on discharge have the worst prognosis. Moreover, worsening or lack of improvement in BUN during hospitalization is a worse prognostic predictor. To the best of our knowledge, this is the first trial to discuss the BUN change during hospitalization in HF.
Zircon U–Pb geochronology and Sr–Nd–Pb–Hf isotopic constraints on the timing and origin of the Early Cretaceous igneous rocks in the Yongxin gold deposit in the Lesser Xing'an Range, NE China
Authors: Zhao Zhong‐Hai , Sun Jing‐Gui , Li Guang‐Hui , Xu Wen‐Xi , Lü Chang‐Lu , Guo Yan , Liu Jin , Zhang Xu 
Published: June 2019

The Lesser Xing'an Range in NE China is an important gold district. However, the age and genesis of Early Cretaceous magmatic rocks that are coeval with gold mineralization remain obscure. A suite of Early Cretaceous igneous rocks in a newly discovered gold deposit at Yongxin was conducted zircon U–Pb dating and Hf isotope and bulk‐rock geochemistry and Sr–Nd–Pb isotope analyses. A dacite of the Guanghua Formation and an andesite of the Longjiang Formation have zircon U–Pb ages of 111.7 ± 1.5 Ma and 119.7 ± 1.9 Ma, respectively. The dacite has zircon εHf(t) values of 5.4 to 12.0 and depleted bulk‐rock Sr–Nd–Pb isotopes ((87Sr/86Sr)i = 0.7049 to 0.7056, εNd(t) = 1.2 to 2.5, (206Pb/204Pb)i = 18.202 to 18.320). The andesite has zircon εHf(t) values of 5.6 to 13.6, (87Sr/86Sr)i of 0.7049 to 0.7051, εNd(t) of 1.0 to 1.6, and (206Pb/204Pb)i of 18.199 to 18.297. The ~120 Ma diorite porphyry and granite porphyry have zircon εHf(t) values of 3.7 to 10.0 and 3.6 to 10.2, respectively. These two units show large variations of 87Rb/86Sr ratios (<1) and similar Sr–Nd–Pb isotopes compositions. All rock units are enriched in light rare earth elements and large‐ion lithophile elements and depleted in high‐field‐strength elements. The formation of Yongxin Early Cretaceous igneous rocks was related to variable degrees of partial melting from Jurassic basalt in the lower crust with significant contribution from ancient continental materials. The low Sr/Y ratios (2–24) and negative correlations between Sr, Eu/Eu, and SiO2 indicate that magmas of the Early Cretaceous igneous rocks at Yongxin have low water content and thus have low potentiality for porphyry copper mineralization.
Balance with the interactive size effects of display, target, and key spacing in tablet tapping, dragging, and typing tasks
Authors: Lai Chih‐Chun 
Published: June 2019

AbstractThis study aimed to expand the current demonstration of display size effects from pointing tasks to dragging and tap‐typing tasks to investigate the effects of influential factors on the performance of touchscreen tablets. From 7‐ to 11‐in. displays, the index of difficulty was kept constant by increasing the target amplitudes and widths (6.0–9.5 mm) proportionally, and the key spacing were, respectively, 13.5 × 7.3–21.5 × 11.5 mm with 0‐mm key gaps. The results demonstrated that simple task types (complexities) reinforced the display size effects and that the effects interacted with target sizes (including amplitude/width scaling) and key spacing to reflect increasing efficiency and usability with increasing sizes. Gender effects were only significant in subjective assessments. Display sizes approaching 10 in., target sizes not less than 7 mm (optimal 9–10 mm) and key spacing larger than 17.5 mm induced the effects of motor scale (the scale of the upper limb joint coordination) and interacted with one another to result in the optimal performance and usability.
One‐year follow‐up of ovarian reserve by three methods in women after laparoscopic cystectomy for endometrioma and benign ovarian cysts
Authors: Kostrzewa Marta , Wilczyński Jacek R. , Głowacka Ewa , Żyła Monika , Szyłło Krzysztof , Stachowiak Grzegorz 
Published: June 2019

AbstractObjectiveTo determine the long‐term impact of laparoscopic cystectomy for endometriomas and benign cysts on ovarian reserve and selection of the most effective method of assessment.MethodsThe present study was carried out between November 2013 and December 2016. Participants were assigned to laparoscopic cystectomy for diagnosed unilateral benign ovarian cysts and divided into groups: the endometrioma group (EG) (n=35) and the other benign ovarian tumor group (OG) (n=35). Before and at 3 and 12 months after the procedure, transvaginal ultrasonography was performed to assess antral follicle count (AFC) and ovarian volume (OvVol); laboratory tests were ordered for anti‐Műllerian hormone (AMH) serum concentration assays. Pregnancy rates were counted in a 12‐month follow‐up. Statistica12 software was used for analysis.ResultsThe present study included 70 women aged 18–40 years. AMH serum concentration decreased significantly 3 months after laparoscopic cystectomy (4.89 ± 3.66 ng/mL to 3.45 ± 3.37 ng/mL; P<0.001). A greater decrease of AMH concentrations was observed in the EG (45.39% vs 14.87%; P=0.021). Twelve months of observation revealed a suppression in the drop of the AMH concentration, while AFC and OvVol remained unaffected. The likelihood of spontaneous pregnancy was three times higher in the OG (hazard ratio [HR] 3.57, 95% confidence interval [CI] 1.08–12.5).ConclusionThere was a significant decline in AMH levels in the EG 3 months after cystectomy. No further fall in AMH concentration was observed in the 12‐month follow‐up. The serum AMH concentration could be considered a valuable marker for ovarian reserve assessment after laparoscopic cystectomy.
Impact on pregnancy outcomes of exposure to military stress during the first or second trimester as compared with the third trimester
Authors: Gluck Ohad , Grin Leonti , Mizrachi Yossi , Leytes Sophia , Namazov Ahmed , Anteby Eyal , Bar Jacob , Kovo Michal 
Published: June 2019

AbstractObjectiveTo compare pregnancy outcomes after exposure to military stress in different trimesters of pregnancy.MethodsA retrospective study of medical records of deliveries in the Wolfson (WMC) and Barzilai (BMC) medical centers in Israel between July 2014 and April 2015. All parturients were exposed to military stress for 51 days during pregnancy. Pregnancy outcomes were compared between those exposed to military stress in the first or second trimester, and those exposed in the third trimester. Outcomes were also compared between WMC (a new‐onset military stress exposure area) and BMC (a chronic military stress exposure area).ResultsAt WMC, women exposed in the first or second trimester (n=2657) had a higher rate of preterm delivery (<37 weeks) as compared with those exposed in the third trimester (n=2037; 214 [8.1%] vs 121 [5.9%]; P=0.005). At BMC, women exposed in the first or second trimester (n=2208) had a tendency toward lower rates of diabetes mellitus (P=0.055) and macrosomia [103 (4.7%) vs 84 (6.3%); P=0.037], as compared with those exposed in the third trimester (n=1337).ConclusionExposure to military stress during pregnancy had different impacts on pregnancy outcomes, depending on the time of exposure and whether continuous exposure to stress occurred.
Neurofilament levels in patients with neurological diseases: A comparison of neurofilament light and heavy chain levels
Authors: Kušnierová Pavlína , Zeman David , Hradílek Pavel , Čábal Martin , Zapletalová Olga 
Published: June 2019

AbstractBackgroundNeurofilaments are the major cytoskeletal components of neurons, and cell injury leads to their release into the surrounding area. The aim of this study was to compare the cerebrospinal fluid (CSF) and serum (S) concentrations of neurofilament light chains (NFLs) and phosphorylated neurofilament heavy chains (pNFHs).MethodsNeurofilament concentrations were measured in CSF and S samples from 172 patients using three enzyme‐linked immunosorbent assays. Excel, Stata version 13, MedCal version 17.9.7., and NCSS 2007 software were used for the statistical analysis.ResultsThere was a statistically significant correlation between the concentrations of CSF NFL and CSF pNFH (rs = 0.748; n = 89; P < 0.001), but Passing‐Bablok regression showed systematic deviation between the values obtained using the two assays. This indicates that the assays were not interchangeable. CSF pNFH and S pNFH concentrations showed low correlation. The kappa statistic showed moderate conformity between CSF pNFH and CSF NFL concentrations (κ = 0.556).ConclusionsThe CSF NFL and CSF pNFH assays gave clinically consistent results that reflected the degree of axonal damage, independent of any particular neurological diagnosis. The S pNFH assays had a lower predictive value due to the low correlation coefficient and the kappa index of the CSF pNFH method.