bluuebunny/crossref_metadata_2025_split huggingface dataset:
A bronchoalveolar lavage‐driven antimicrobial treatment improves survival in hematologic malignancy patients with detected lung infiltrates: A prospective multicenter study of the SEIFEM group
Authors: Marchesi Francesco , Cattaneo Chiara , Criscuolo Marianna , Delia Mario , Dargenio Michelina , Del Principe Maria Ilaria , Spadea Antonio , Fracchiolla Nicola Stefano , Melillo Lorella , Perruccio Katia , Alati Caterina , Russo Domenico , Garzia Mariagrazia , Brociner Marco , Cefalo Mariagiovanna , Armiento Daniele , Cesaro Simone , Decembrino Nunzia , Mengarelli Andrea , Tumbarello Mario , Busca Alessandro , Pagano Livio ,   on behalf of the Sorveglianza Epidemiologica Infezioni nelle Emopatie (SEIFEM) Group
Published: July 2019

AbstractBronchoalveolar lavage (BAL) is recommended for diagnosing lung infiltrates (LI) in patients with hematologic malignancy (HM). Prospective data on the impact of BAL on survival are still lacking. We conducted a prospective observational study on patients who performed BAL for LI among 3055 HM patients hospitalized from January to September 2018. The BAL was performed in 145 out of 434 patients who developed LI, at a median time of four days from LI detection. The median age was 60 (1‐83). Most patients had an acute myeloid leukemia/myelodisplastic syndrome (81), followed by lymphoma (41), acute lymphoblastic leukemia (27), and other types of HM (36). A putative causal agent was detected in 111 cases (76%), and in 89 cases (61%) the BAL results provided guidance to antimicrobial treatment. We observed a significantly improved outcome of LI at day +30 in patients who could receive a BAL‐driven antimicrobial treatment (improvement/resolution rate: 71% vs 55%; P = .04). Moreover, we observed a significantly improved outcome in 120‐day overall survival (120d‐OS) (78% vs 59%; P = .009) and 120‐day attributable mortality (120d‐AM) (11% vs 30%; P = 0.003) for patients who could receive a BAL‐driven treatment. The multivariate analysis showed that BAL‐driven antimicrobial treatment was significantly associated with better 120d‐OS and lower 120d‐AM. We did not observe any severe adverse events. In conclusion BAL allows detection of a putative agent of LI in about 75% of cases, it is feasible and well tolerated in most cases, demonstrating that a BAL‐driven antimicrobial treatment allows improvement of clinical outcome and survival.
QbD approached comparison of reaction mechanism in microwave synthesized gold nanoparticles and their superior catalytic role against hazardous nirto‐dye
Authors: Alam Md Sabir , Javed Md Noushad , Pottoo Faheem Hyder , Waziri Aafrin , Almalki Faisal A. , Hasnain Md Saquib , Garg Arun , Saifullah Md Khalid 
Published: July 2019

Microwave irradiation (MI) process characteristically enables extremely rapid “in‐core” heating of dipoles and ions, in comparison to conventional thermal (conductance) process of heat transfer. During the process of nanoparticles synthesis, MI both modulates functionality behaviors as well as dynamic of reaction in favorable direction. So, MI providing a facile, favorable and alternative approach during nanoparticles synthesis nanoparticles with enhanced catalytic performances.Although, conventionally used reducing and capping reagents of synthetic origin, are usually environmentally hazardous and toxic for living organism. But, in absence of suitable capping agent; stability, shelf life and catalytic activity of metallic nanoparticles adversely affected. However, polymeric templates which emerged as suitable choice of agent for both reducing and capping purposes; bearing additional advantages in terms of catalyst free one step green synthesis process with high degree of biosafety and efficiency.Another aspect of current works was to understand role of process variables in growth mechanism and catalytic performances of microwave processed metallic nanoparticles, as well as comparison of these parameters with conventional heating method. However, due to poor prediction ability with previously published architect OFAT (One factor at a time) design with these nanoparticles as well as random selection of process variables with their different levels, such comparison couldn't be possible.Hence, using gum Ghatti (Anogeissus latifolia) as a model bio‐template and under simulated reaction conditions; architect of QbD design systems were integrated in microwave processed nanoparticles to establish mechanistic role these variables. Furthermore, in comparison to conventional heating; we reported well validated mathematical modeling of process variables on characteristic of nanoparticles as well as synthesized gold nanoparticles of desired and identical dimensions, in both thermal and microwave‐based processes. Interestingly, despite of identical dimension, MI processed gold nanoparticles bearing higher efficiency (kinetic rate) against remediation of hazardous nitro dye (4‐nitrophenol), into safer amino (4‐aminophenol) analogues.
Epoxidation of cyclohexene with H2O2 over efficient water‐tolerant heterogeneous catalysts composed of mono‐substituted phosphotungstic acid on co‐functionalized SBA‐15
Authors: Jin Manman , Niu Qingtao , Guo Zhenmei , Lv Zhiguo 
Published: July 2019

A series of Keggin‐type heteropolyacid‐based heterogeneous catalysts (Co‐/Fe‐/Cu‐POM‐octyl‐NH3‐SBA‐15) were synthesized via immobilized transition metal mono‐ substituted phosphotungstic acids (Co‐/Fe‐/Cu‐POM) on octyl‐amino‐co‐functionalized mesoporous silica SBA‐15 (octyl‐NH2‐SBA‐15). Characterization results indicated that Co‐/Fe‐/Cu‐POM units were highly dispersed in mesochannels of SBA‐15, and both types of Brønsted and Lewis acid sites existed in Co‐/Fe‐/Cu‐POM‐octyl‐NH3‐SBA‐15 catalysts. Co‐POM‐octyl‐NH3‐SBA‐15 catalyst showed excellent catalytic performance in H2O2‐mediated cyclohexene epoxidation with 83.8% of cyclohexene conversion, 92.8% of cyclohexene oxide selectivity, and 98/2 of epoxidation/allylic oxidation selectivity. The order of catalytic activity was Co‐POM‐octyl‐NH3‐SBA‐15 > Fe‐POM‐octyl‐NH3‐SBA‐15 > Cu‐POM‐octyl‐NH3‐SBA‐15. In order to obtain insights into the role of ‐octyl moieties during catalysis, an octyl‐free catalyst (Co‐POM‐NH3‐SBA‐15) was also synthesized. In comparison with Co‐POM‐NH3‐SBA‐15, Co‐POM‐octyl‐NH3‐SBA‐15 showed enhanced catalytic properties (viz. activity and selectivity) in cyclohexene epoxidation. Strong chemical bonding between ‐NH3+ anchored on the surface of SBA‐15 and heteropolyanions resulted in excellent stability of Co‐POM‐octyl‐NH3‐SBA‐15 catalyst, and it could be reused six times without considerable loss of activity.
Significant enhancement of fracture toughness and mechanical properties of epoxy resin using CTBN‐grafted epoxidized linseed oil
Authors: Bach Quang‐Vu , Vu Cuong Manh , Vu Huong Thi , Vu Hoa Binh , Van Nguyen Tuyen , Chang Soon Wong , Nguyen Dinh Duc , Thi Tuyet Anh Dang , Doan Vu Ngoc 
Published: July 2019

ABSTRACTCarboxyl‐terminated poly(acrylonitrile‐co‐butadiene) (CTBN)‐grafted epoxidized linseed oil (ELO) (CTBN‐g‐ELO) was synthesized and used as an effective toughener to simultaneously enhance the mechanical properties and fracture toughness of epoxy resin (EP). The ELO was fabricated from linseed oil via epoxidation processing. The characteristics of the ELO and CTBN‐g‐ELO, such as the average molecular weight and chemical structure, were determined using gel permeation chromatography, proton nuclear magnetic resonance, and Fourier transform infrared spectroscopy. The effects of the CTBN‐g‐ELO loading on the characteristics of the EP were investigated in detail. The test results indicated that by adding 15 phr CTBN‐g‐ELO, the tensile strength, impact strength, and critical stress intensity factor (KIC) were significantly increased, by approximately 23.62, 91.8, and 33.8%, respectively, compared with pristine EP. The glass‐transition temperature (Tg) and storage modulus, which were examined via dynamic mechanical thermal analysis and differential scanning calorimetry, respectively, exhibited decreasing trends. Scanning electron microscopy revealed that the CTBN‐g‐ELO existed as spherical particles in the EP, helping to stop the crack growth and change the crack growth directions. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci.2020,137, 48276.
Simultaneous quantification of ondansetron and tariquidar in rat and human plasma using a high performance liquid chromatography‐ultraviolet method
Authors: Chong Yae Eun , Chiang Manting , Deshpande Kiran , Haroutounian Simon , Kagan Leonid , Lee Jong Bong 
Published: July 2019

AbstractOndansetron, a widely used antiemetic agent, is a P‐glycoprotein (P‐gp) substrate and therefore expression of P‐gp at the blood–brain barrier limits its distribution to the central nervous system (CNS), which was observed to be reversed by coadministration with P‐gp inhibitors. Tariquidar is a potent and selective third‐generation P‐gp inhibitor, and coadministration with ondansetron has shown improved ondansetron distribution to the CNS. There is currently no reported bioanalytical method for simultaneously quantifying ondansetron with a third‐generation P‐gp inhibitor. Therefore, we aimed to develop and validate a method for ondansetron and tariquidar in rat and human plasma samples. A full validation was performed for both ondansetron and tariquidar, and sample stability was tested under various storage conditions. To demonstrate its utility, the method was applied to a preclinical pharmacokinetic study following coadministration of ondansetron and tariquidar in rats. The presented method will be valuable in pharmacokinetic studies of ondansetron and tariquidar in which simultaneous determination may be required. In addition, this is the first report of a bioanalytical method validated for quantification of tariquidar in plasma samples.
Highly Reversible Lithium Storage of Nitrogen‐Doped Carbon@MnO Hierarchical Hollow Spheres as Advanced Anode Materials
Authors: Wang Yong , Zhang Fanchao , Guo Wenbin , Rao Shun , Mao Peiyuan , Xiao Pandeng 
Published: July 2019

AbstractThe practical implementation of MnO‐based anode materials is still obstructed because of their short cyclic life and unsatisfactory rate performance, attributable to low conductivity, large volume variation and self‐aggregation of MnO during intense cycles. To overcome these obstacles, we successfully fabricated nitrogen‐doped carbon@MnO hierarchical hollow spheres through a novel approach. As anode nanomaterials for Li‐ion batteries, the nanocomposite possesses a highly reversible capacity of 1302 mAh g−1 after the 200th cycle at 0.1 Ag−1 and 964 mAh g−1 after the 500th cycle at 0.5 Ag−1, respectively. The prominent electrochemical performances of the nanocomposite may result from synthetic effects of nitrogen‐doped carbon hollow structures, nanosized MnO and the gradual generation of high‐oxide‐state manganese oxide on nitrogen‐doped carbon hollow spheres during intensive cycles. The aforementioned results also demonstrate that MnO nanocrystals can be well utilized by attaching to nitrogen‐doped carbon hollow spheres, which is a valid way to achieve excellent lithium storage properties for transition metal oxides.
Sn‐Pb Binary Perovskite Films with High Crystalline Quality for High Performance Solar Cells
Authors: Guo Xuankun , Chen Jiehuan , Lian Xiaomei , Wang Yaqin , Wu Gang , Chen Hongzheng 
Published: July 2019

Summary of main observation and conclusionAs an environmentally friendly perovskite material with low bandgap, Tin (Sn)‐based perovskite has drawn much attention. A simple and effective method for fabricating high‐quality Sn‐Pb binary perovskite film is highly desired. Here, with methylammonium chloride (MACl) post‐treatment to assist vertical recrystallization, we fabricated high quality FA0.75Cs0.25Pb0.5Sn0.5I3 perovskite film via one‐step processing method. This recrystallization method was first used in Sn‐based perovskite. The obtained film consists of vertically aligned grains with high crystallinity, which contributes to a power conversion efficiency (PCE) of 14.03% in corresponding perovskite solar cell (PVSC). The cells maintained 80% of their initial PCEs after being stored for 30 d in glove‐box. This simple, effective method provides an easy way to fabricate high performance Sn‐Pb binary PVSC.
Late‐onset anorectal disease and psychosocial impact in survivors of childhood cancer: A report from the Childhood Cancer Survivor Study
Authors: Madenci Arin L. , Dieffenbach Bryan V. , Liu Qi , Yoneoka Daisuke , Knell Jamie , Gibson Todd M. , Yasui Yutaka , Leisenring Wendy M. , Howell Rebecca M. , Diller Lisa R. , Krull Kevin R. , Armstrong Gregory T. , Oeffinger Kevin C. , Murphy Andrew J. , Weil Brent R. , Weldon Christopher B. 
Published: July 2019

BackgroundThe prevalence and associated psychosocial morbidity of late‐onset anorectal disease after surgery and radiotherapy for the treatment of childhood cancer are not known.MethodsA total of 25,530 survivors diagnosed between 1970 and 1999 (median age at cancer diagnosis, 6.1 years; age at survey, 30.2 years) and 5036 siblings were evaluated for late‐onset anorectal disease, which was defined as a self‐reported fistula‐in‐ano, self‐reported anorectal stricture, or pathology‐ or medical record–confirmed anorectal subsequent malignant neoplasm (SMN) 5 or more years after the primary cancer diagnosis. Piecewise exponential models compared the survivors and siblings and examined associations between cancer treatments and late‐onset anorectal disease. Multiple logistic regression with generalized estimating equations was used to evaluate associations between late‐onset anorectal disease and emotional distress, as defined by the Brief Symptom Inventory 18 (BSI‐18), and health‐related quality of life, as defined by the Medical Outcomes Study 36‐Item Short Form Health Survey (SF‐36).ResultsBy 45 years after the diagnosis, 394 survivors (fistula, n = 291; stricture, n = 116; anorectal SMN, n = 26) and 84 siblings (fistula, n = 73; stricture, n = 23; anorectal neoplasm, n = 1) had developed late‐onset anorectal disease (adjusted rate ratio [RR] for survivors vs siblings, 1.2; 95% confidence interval [CI], 1.0‐1.5). Among survivors, pelvic radiotherapy with ≥30 Gy within 5 years of the cancer diagnosis was associated with late‐onset anorectal disease (adjusted RR for 30‐49.9 Gy vs none, 1.6; 95% CI, 1.1‐2.3; adjusted RR for ≥50 Gy vs none, 5.4; 95% CI, 3.1‐9.2). Late‐onset anorectal disease was associated with psychosocial impairment in all BSI‐18 and SF‐36 domains.ConclusionsLate‐onset anorectal disease was more common among childhood cancer survivors who received higher doses of pelvic radiotherapy and was associated with substantial psychosocial morbidity.
Facile Formation of Stable Water‐Dispersed Luminescent Silicon Nanocrystals by Laser Processing in Liquid: Toward Fluorescent Labeling for Bio‐Imaging
Authors: Yuan Ze , Nakamura Toshihiro , Chinnathambi Shanmugavel , Pu Yanbai , Shirahata Naoto , Matsuishi Kiyoto 
Published: July 2019

AbstractWe herein develop a facile formation process of a water‐dispersed red luminescent undecenoic acid‐functionalized silicon nanocrystal (UA‐F: Si‐nc) via pulsed laser irradiation of porous silicon (PSi) in an organic solvent. The formed UA‐F: Si‐nc has a high stability against pH changes in aqueous solution and photo‐irradiation in water without any multi‐step surface treatments. Such a robust aqueous surface protection of Si‐nc is caused by hydrophilic organic group terminations and subsequent surface protection of OH bonding. From the viability and in vitro bio‐imaging tests against Hela cells and A549 cells, we confirmed that UA‐F: Si‐nc has very low cytotoxicity due to the essential biocompatibility of silicon and remains exhibiting a bright red luminescence in the cells. Because of its high stability in water as well as biocompatibility, UA‐F: Si‐nc is expected to act as a fluorescent label of cellular imaging.
Ultrasmall Gold Nanocluster Based Antibacterial Nanoaggregates for Infectious Wound Healing
Authors: Ravindran Girija Aswathy , Balasubramanian Sivakumar , Bright Richard , Cowin Allison J. , Goswami Nirmal , Vasilev Krasimir 
Published: July 2019

AbstractWound infections are a growing challenge and significantly delay the healing process. To overcome this challenge, nanotechnology‐inspired treatments have recently emerged as promising alternatives to conventional drugs and antibiotics. Here, we introduce a new type of antimicrobial nanoaggregate that integrates the intrinsic properties of ultra‐small gold nanoclusters (AuNCs) with a biocompatible antimicrobial polymer, namely, chitosan (CS). The synergetic combination created from the AuNCs and CS in the nanoaggregates resulted in superior antimicrobial activity against Gram‐negative Escherichia coli and Gram‐positive Staphylococcus aureus bacterial strains, when compared with their individual components. Furthermore, the nanoaggregates also facilitate rapid wound healing without exhibiting any cytotoxic effects in mammalian cells. These nanoaggregates may become a potent component of innovative wound healing therapies.
Associations of pathogen‐specific and host‐specific characteristics with disease outcome in patients with Staphylococcus aureus bacteremic pneumonia
Authors: Sharma‐Kuinkel Batu K , Tkaczyk Christine , Bonnell Jessica , Yu Li , Tovchigrechko Andrey , Tabor David E , Park Lawrence P , Ruffin Felicia , Esser Mark T , Sellman Bret R , Fowler Vance G , Ruzin Alexey 
Published: July 2019

AbstractObjectiveTo understand the relationships of Staphylococcus aureus (SA) bacteremic pneumonia (SABP) outcome with patient‐specific and SA‐specific variables.MethodsWe analysed SA bloodstream isolates and matching sera in SABP patients by sequencing SA isolates (n = 50) and measuring in vitro AT production, haemolytic activity and expression of ClfA and ClfB. Controls were sera from gram‐negative bacteremia patients with or without pneumonia and uninfected subjects. Levels of IgGs, IgMs and neutralizing antibodies (NAbs) against SA antigens were quantified and analysed by one‐way ANOVA. Associations of patient outcomes with patient variables, antibody levels and isolate characteristics were evaluated by univariate and multivariate logistic regression analyses.ResultsSABP patients had higher levels of IgGs against eight virulence factors and anti‐alpha toxin (AT) NAbs than uninfected controls. Levels of IgG against AT and IgMs against ClfA, FnbpA and SdrC were higher in clinically cured SABP patients than in clinical failures. Anti‐LukAB NAb levels were elevated in all cohorts. Increased odds of cure correlated with higher haemolytic activity of SA strains, longer time between surgery and bacteremia (> 30 days), longer duration of antibiotic therapy, lower acute physiology and total APACHE II scores, lack of persistent fever for > 72 h and higher levels of antibodies against AT (IgG), ClfA (IgM), FnbpA (IgM) and SdrC (IgM).DiscussionLimitations included the cross‐sectional observational nature of the study, small sample size and inability to measure antibody levels against all SA virulence factors.ConclusionOur results suggest that SABP patients may benefit from immunotherapy targeting multiple SA antigens.
Linking resting‐state networks and social cognition in schizophrenia and bipolar disorder
Authors: Jimenez Amy M. , Riedel Philipp , Lee Junghee , Reavis Eric A. , Green Michael F. 
Published: July 2019

AbstractIndividuals with schizophrenia and bipolar disorder show alterations in functional neural connectivity during rest. However, resting‐state network (RSN) disruptions have not been systematically compared between the two disorders. Further, the impact of RSN disruptions on social cognition, a key determinant of functional outcome, has not been studied. Forty‐eight individuals with schizophrenia, 46 with bipolar disorder, and 48 healthy controls completed resting‐state functional magnetic resonance imaging. An atlas‐based approach was used to examine functional connectivity within nine RSNs across the cortex. RSN connectivity was assessed via nonparametric permutation testing, and associations with performance on emotion perception, mentalizing, and emotion management tasks were examined. Group differences were observed in the medial and lateral visual networks and the sensorimotor network. Individuals with schizophrenia demonstrated reduced connectivity relative to healthy controls in all three networks. Individuals with bipolar disorder demonstrated reduced connectivity relative to controls in the medial visual network and connectivity within this network was significantly positively correlated with emotion management. In healthy controls, connectivity within the medial and lateral visual networks positively correlated with mentalizing. No significant correlations were found for either visual network in schizophrenia. Results highlight the role of altered early visual processing in social cognitive deficits in both schizophrenia and bipolar disorder. However, individuals with bipolar disorder appear to compensate for disrupted visual network connectivity on social cognitive tasks, whereas those with schizophrenia do not. The current study adds clarity on the neurophysiology underlying social cognitive deficits that result in impaired functioning in serious mental illness.
Wildfire severity: Environmental effects revealed by soil magnetic properties
Authors: Jordanova Neli , Jordanova Diana , Barrón Vidal 
Published: July 2019

AbstractStrong wildfires pose significant damage to all soil qualities and lead to land degradation. The complex nature and properties of fire‐derived materials require multidisciplinary efforts for their reliable characterization. The main objective of our study was to evaluate the suitability of magnetic properties of fire‐affected soils as proxy parameters for wildfire severity and to relate magnetic signature of burnt soils to carbon and nitrogen contents as influenced by wildfires. We present mineral magnetic investigation of 22 sites with wildfire‐affected soils and 17 nonburnt soils from nearby locations. We employed measurements of magnetic susceptibility and anhysteretic remanence in combination with scanning and transmission electron microscopy observations on magnetic particles from burnt soils and ashes. Bulk soil and vegetation ash analyses of total carbon and nitrogen, organic carbon, and elemental content were carried out as well. We show that pyrogenic magnetic enhancement is restricted to the uppermost 0‐ to 2‐cm soil depth and can be used as a proxy for wildfire severity. Strong wildfires lead to the production of nanometer‐sized superparamagnetic magnetite and/or maghemite particles and smaller amount of single‐domain fraction. These strongly magnetic minerals have typical characteristics of high‐temperature combustion products with spherical shape and diameters between 0.1 and 2 μm. Fire‐affected soils show relative enrichment with phosphorous, manganese, and heavy metals (Cu, Pb, Zn, Ni, Co, and As) calculated with respect to soils from nonburnt nearby localities. Our results demonstrate the potential of environmental magnetic methods as an additional tool for assessment of wildfire severity and the content of main soil nutrients.