bluuebunny/crossref_metadata_2025_split huggingface dataset:
A machine learning assisted preliminary design methodology for bolted composite joints in large structures
Authors: Azeem O.A.I. 
Published: November 2024

AbstractDamage initiation hotspots around features, such as bolts and ply drops, must be investigated during the preliminary design phase of large composite structures, such as composite airframes. A global-local modelling approach is commonly employed to perform this investigation, whereby a global low-fidelity model is used to drive high-fidelity local models around the features of interest. However, this methodology is slow, repetitive and expert-dependent. In this investigation, we address these issues by applying machine learning techniques to this global-local modelling framework and demonstrate the time-saving benefit when predicting damage initiation of bolted composite joints. Feature engineering of model inputs and outputs, and appropriate customisation of machine learning methods enables damage initiation prediction. Special consideration is given to the boundary conditions that must be varied to simulate the response of the bolted composite joints. Results show over three orders of magnitude time-saving benefit and satisfactory accuracy of the proposed methodology. This indicates its potential to be developed further into a rapid design and optimisation tool.
Multi-granularity onboard decision method for optical space surveillance satellite
Authors: Sun Y.J. , Dong Y.F. 
Published: November 2024

Abstract
Critical space assets require continuous monitoring to prevent potential losses. Auxiliary satellites protect these assets by observing and tracking approaching targets. Although observation satellites can make rapid autonomous onboard decisions, they face challenges due to limited computational capacity. The two mainstream command and control methods currently available do not meet the demands of onboard decision-making. Highly procedural decision-making methods require extended decision times, while rapid-response intuitive or heuristic methods carry significant error risks. To address this, this paper proposes a multi-granularity decision-making method for optical space surveillance satellites. First, multi-granularity relative orbit determination algorithm models and multi-granularity impulsive orbit manoeuver algorithm models were developed. Based on these models, a granularity selection method for sequential three-way decisions is proposed. In non-emergency situations, fine-granularity models are preferred to conserve fuel, while in emergency situations, coarse-granularity models are used to enhance decision-making speed and reduce positional deviations caused by the manoeuvering game. In random multi-scenario tests, the proposed method demonstrates lower average terminal positional deviations and fuel consumption compared to single-granularity (highly procedural or rapid-response) and random-granularity methods.
The need for climate data stewardship: 10 tensions and reflections regarding climate data governance
Authors: Verhulst Stefaan G. 
Published: November 2024

Abstract
Datafication—the increase in data generation and advancements in data analysis—offers new possibilities for governing and tackling worldwide challenges such as climate change. However, employing data in policymaking carries various risks, such as exacerbating inequalities, introducing biases, and creating gaps in access. This paper articulates 10 core tensions related to climate data and its implications for climate data governance, ranging from the diversity of data sources and stakeholders to issues of quality, access, and the balancing act between local needs and global imperatives. Through examining these tensions, the article advocates for a paradigm shift towards multi-stakeholder governance, data stewardship, and equitable data practices to harness the potential of climate data for the public good. It underscores the critical role of data stewards in navigating these challenges, fostering a responsible data ecology, and ultimately contributing to a more sustainable and just approach to climate action and broader social issues.
Pressure-driven viscoelastic flow in axisymmetric geometries with application to the hyperbolic pipe
Authors: Housiadas Kostas D. , Beris Antony N. 
Published: November 2024

We investigate theoretically the steady incompressible viscoelastic flow in a rigid axisymmetric cylindrical pipe with varying cross-section. We use the Oldroyd-B viscoelastic constitutive equation to model the fluid viscoelasticity. First, we derive exact general formulae: for the total average pressure-drop as a function of the wall shear rate and the viscoelastic axial normal extra-stress; for the viscoelastic extra-stress tensor and the Trouton ratio as functions of the fluid velocity on the axis of symmetry; and for the viscoelastic extra-stress tensor along the wall in terms of the shear rate at the wall. Then we exploit the classic lubrication approximation, valid for small values of the square of the aspect ratio of the pipe, to simplify the original governing equations. The final equations are solved analytically using a regular perturbation scheme in terms of the Deborah number, De, up to eighth order in De. For a hyperbolically shaped pipe, we reveal that the reduced pressure-drop and the Trouton ratio can be recast in terms of a modified Deborah number, Dem, and the polymer viscosity ratio, η, only. Furthermore, we enhance the convergence and accuracy of the eighth-order solutions by deriving transformed analytical formulae using Padé diagonal approximants. The results show the decrease of the pressure drop and the enhancement of the Trouton ratio with increasing Dem and/or increasing η. Comparison of the transformed solutions with numerical simulations of the lubrication equations using pseudospectral methods shows excellent agreement between the results, even for high values of Dem and all values of η, revealing the robustness, validity and efficiency of the theoretical methods and techniques developed in this work. Last, it is shown that the exact solution for the Trouton ratio gives a well-defined and finite solution for any value of Dem and reveals the reason for the failure of the corresponding high-order perturbation series for Dem > 1/2.
Morphology in action: Diminutives in Brazilian obstetric and gynecological consultations
Authors: Ostermann Ana Cristina , Raymond Chase Wesley , Drew Paul 
Published: November 2024

Abstract
While scholars have long been interested in the formation, meaning, and uses of diminutive morphology across languages, the present study illustrates a novel approach to their examination. Drawing upon a corpus of recordings of Brazilian obstetric and gynecological consultations conducted in Portuguese, our analytic points of departure are action and the sequential progression of interaction. We address these by investigating moments where diminutive forms and base forms of a lexical item are used in close proximity. This approach allows us to unpack and particularize the generic, overarching function of ‘mitigation’ in terms of the specific actions being constituted by the participants—here, offering reassurance, attenuating intrusiveness, pursuing acquiescence, and launching activity transitions. We conclude by discussing some of the implications of this analysis and suggesting some potential avenues for future comparative research. (Portuguese, Brazil, gynecology, obstetrics, healthcare, morphology, pragmatics, granularity, methodology, conversation analysis)*
What's in a Name? Through Comic Titles to Caecilius Statius
Authors: Barbiero Emilia A. 
Published: November 2024

AbstractThis article takes a novel approach to fragmentary Roman comic playwright Caecilius Statius by exploring the titles attested for his comedies. Informed by Genette's theory on the title qua paratext, it argues that titles are distinct artifacts of Caecilius’ dramatic production designed to circulate without the texts they label and, consequently, it treats them as legitimate objects of interpretation in and of themselves. Analysis of ten titles in both Greek and Latin reveals that Caecilius Statius’ titles are polysemous, bilingual and profoundly meaningful in their engagement with the genre of New Comedy and with translation as a social and cultural phenomenon of middle republican Rome. But given that the titles of Roman comedy are largely uninvestigated by scholarship, this piece begins by arguing for their author-ity, setting forth the evidence for comic titles’ origins, function and transmission. In so doing, it demonstrates the palliata's textuality and challenges the communis opinio regarding comic scripts’ passage from stage to page. A Supplementary Appendix available online (10.1017/S0075435824000285) presents the evidence for the titles of Caecilius’ plays.
Better safe than sorry: Why great powers accommodate high-value hedgers
Authors: Simón Luis , Figiaconi Fabio 
Published: November 2024

Abstract
Despite the growing interest in secondary state efforts to avoid choosing sides in great power competition, International Relations scholars have paid scant attention to the question of how great powers respond to secondary state ‘hedging’. We offer a first approximation for this important question by focusing on ‘high-value’ hedgers, i.e. secondary states whose location or capabilities afford them the potential to tip the scales in a great power war. We posit that great powers are likely to accommodate high-value hedgers and refrain from trying to manipulate their alignment choice. This is because the likelihood and costs of losing a high-value hedger are such that competing great powers would rather be safe than sorry. Concretely, we expect established and rising great powers to (re)assure high-value hedgers: the former by demonstrating their commitment to a regional balance of power, and the latter by showing they harbour no ill intent towards the hedging secondary state. To probe our argument, we examine how Great Britain and Germany responded to Dutch hedging in the early 20th century, and how the United States and China are responding to Singapore’s hedging today.
Evaluating the roles of food matrix, lipid micronutrients and bioactives in controlling postprandial hypertriglyceridaemia and inflammation
Authors: Bravo-Núñez Ángela , Valéro René , Reboul Emmanuelle 
Published: November 2024

Abstract
Lipids play an important role in human nutrition. Although adequate lipid consumption is necessary for an optimal functioning of the human body, overconsumption of saturated fatty acids can lead to postprandial hypertriglyceridaemia, which triggers the development of atherosclerosis. Important parameters that impact postprandial lipaemia and inflammation are related to the matrix structure and the fat-soluble micronutrient profile of ingested foods/lipids, but the specific effect of these parameters should be further studied, as most of the available studies evaluate their effect at fasting state. This review specifically explores the effects of food structure and fat-soluble micronutrients, from either micronutrient-rich foods or supplements, on postprandial hypertriglyceridaemia and inflammation. The review also highlights the potential of emerging biomarkers such as miRNAs or circulating microvesicles, as an alternative to the widely use biomarkers (e.g. low-density lipoproteins or blood concentration of pro-inflammatory cytokines), to identify inflammation associated with postprandial hypertriglyceridaemia at early stages.
In Defense of “Physician-Assisted Suicide”: Toward (and Back to) a Transparent, Destigmatizing Debate
Authors: Fox Brandy M. , Braswell Harold 
Published: November 2024

Abstract
Many bioethicists have recently shifted from using “physician-assisted suicide” (PAS) to “medical aid-in-dying” (MAID) to refer to the act of voluntarily hastening one’s death with the assistance of a medical provider. This shift was made to obscure the practice’s connection to “suicide.” However, as the charge of “suicide” is fundamental to arguments against the practice, “MAID” can only be used by its proponents. The result has been the fragmentation of the bioethical debate. By highlighting the role of human agency—as opposed to natural processes—in causing death, the term “PAS” makes it easier both to perceive potential risks to vulnerable populations and to affirm suicide as a potentially autonomous choice. As such, “PAS” thus more transparently expresses the arguments of both supporters and opponents of the “right to die,” while avoiding the unnecessary stigmatization of suicide and suicidal people which is a result of the usage of “MAID.”
Listening “At the Bedside”: Podcasts as an Emerging Tool for Medical Ethics Education
Authors: Schiff Tamar , Hedlin Margot , Al-Mondhiry Jafar 
Published: November 2024

Abstract
Medical ethics education is crucial for medical students and trainees, helping to shape attitudes, beliefs, values, and professional identities. Exploration of ethical dilemmas and approaches to resolving them provides a broader understanding of the social and cultural contexts in which medicine is practiced, as well as the ethical implications of medical decisions, fostering critical thinking and self-reflection skills imperative to providing patient-centered care. However, exposure to medical ethics topics and their clinical applications can be limited by curricular constraints and the availability of institutional resources and expertise. Podcasts, among other Free Open Access Medical Education (FOAMed) resources, are a novel educational tool that offers particular advantages for self-directed learning, a process by which learners engage in asynchronous educational opportunities outside of traditional academic or clinical settings. Podcasts can be readily distributed to wide audiences and played at any time, reducing barriers to access and offering a level of flexibility that is not possible with traditional forms of education and is well-suited to busy schedules. Podcasts can also use real voices and storytelling to make the content memorable and eminently human. This paper describes the development, production process, and impact of Core IM’s “At the Bedside,” a podcast focusing on issues in medical ethics and the medical humanities, intending to supplement standard bioethics curricula in an accessible, relevant, and engaging way. The authors advocate for broad incorporation of podcasts into medical ethics education.
Do anomalous aortic origin of a coronary artery patients have higher risk of myocardial ischaemia and adverse cardiac events during aortic and mitral valve replacements?
Authors: McCloskey Olivia , Vaidya Kiran , Jiang Michael , Iyer Meghana , Marshall Mayme , Ghobrial Joanna , Firth Austin , Rajeswaran Jeevanantham , Anabila Moses , Pettersson Gosta , Blackstone Eugene , Karamlou Tara 
Published: November 2024

AbstractObjectives:We assessed the effect of anomalous aortic origin of a coronary artery on the risk of early and late postoperative events after aortic or mitral valve replacement in adults.Methods:Between 2005 and 2022, 29,579 adults underwent surgical aortic or mitral valve replacement at Cleveland Clinic. Among these, 29 had an unrepaired coronary artery rising anomalously from the aorta that was not intervened upon during valve surgery, 19 (65%) an anomalous circumflex, and 9 (31%) an anomalous right. Operative outcomes were compared between the 29 patients with anomalous coronary arteries and 87 balancing score (1:3) matched patients with normal coronary origin. Median follow-up was 6.5 years.Results:Among matched groups, major morbidity and mortality 24% (n = 7) in patients with anomalous coronaries and 20% (n = 17) among patients with normal coronary origin (P = .7). Ten-year freedom from coronary reintervention was 83% versus 100% (P[log-rank] = .005), and 10-year survival was 59% versus 53% (P[log-rank] = .8). One patient experienced a coronary injury from valve surgery, in which the incidentally found anomalous retroaortic circumflex was immediately repaired without further complication. There was no coronary reintervention after discharge in the normal coronary origin group and three in the anomalous coronary group; however, only one of these patients required intervention on the anomalous coronary.Conclusions:Anomalous coronaries were uncommon in surgical valve replacement patients at a high-volume centre. The origin and course of each coronary should be assessed before valve replacement. With careful planning, valve replacement does not result in a significantly higher prevalence of postoperative ischaemia, mortality, or reintervention.
The mediating role of COVID-19 anxiety on the relationship between quality of life and spiritual well-being, and hopelessness: A study on cancer patients
Authors: Dığrak Ebru , Akkoç Irfan 
Published: November 2024

Abstract

Objectives
The coronavirus pandemic has caused concern in the community, especially in patients. Spirituality, hopelessness, and quality of life have an impact on the management of the process in cancer patients during these crisis periods. To investigate COVID-19 anxiety’s mediating role in hopelessness’ relationships with the quality of life and spiritual well-being among cancer patients.

Methods
This study used a cross-sectional design to collect data from cancer patients using self-administered questionnaires. The study recruited 176 cancer patients receiving treatment at a university hospital. The participants completed measures of spiritual well-being, COVID-19 anxiety, hopelessness, and quality of life. Following preliminary analyses, a mediation model was analyzed using the PROCESS macro for SPSS, with the bootstrap method applied (model 4).

Results
The results showed that spiritual well-being was negatively associated with COVID-19 anxiety and hopelessness, and positively associated with the quality of life. COVID-19 anxiety was associated positively with hopelessness, and negatively with the quality of life. Moreover, COVID-19 anxiety mediated the relationship between hopelessness, spiritual well-being, and quality of life.

Significance of results
This study provides evidence for COVID-19 anxiety’s mediating role in the relationship between spiritual well-being and quality of life and hopelessness among cancer patients. The findings suggest that interventions aimed at reducing COVID-19 anxiety may be effective in reducing hopelessness among cancer patients, by promoting higher levels of spiritual well-being and improving quality of life.
Lactate utilization in Lace1 knockout mice promotes browning of inguinal white adipose tissue
Authors: Kim Youn Ju , Lee Sang Gyu , Jang Su In , Kim Won Kon , Oh Kyoung-Jin , Bae Kwang-Hee , Kim Hye Jin , Seong Je Kyung 
Published: November 2024

AbstractRecent studies have focused on identifying novel genes involved in the browning process of inguinal white adipose tissue (iWAT). In this context, we propose that the mitochondrial ATPase gene lactation elevated 1 (Lace1) utilizes lactate to regulate the browning capacity of iWAT, specifically in response to challenge with CL-316,243 (CL), a beta3-adrenergic receptor (β3-AR) agonist. The mice were injected with CL over a span of 3 days and exposed to cold temperatures (4–6 °C) for 1 week. The results revealed a significant increase in Lace1 expression levels during beige adipogenesis. Additionally, a strong positive correlation was observed between Lace1 and Ucp1 mRNA expression in iWAT under browning stimulation. To further explore this phenomenon, we subjected engineered Lace1 KO mice to CL and cold challenges to validate their browning potential. Surprisingly, Lace1 KO mice presented increased oxygen consumption and heat generation upon CL challenge and cold exposure, along with increased expression of genes related to brown adipogenesis. Notably, deletion of Lace1 led to increased lactate uptake and browning in iWAT under CL challenge compared with those of the controls. These unique phenomena stem from increased lactate release due to the inactivation of pyruvate dehydrogenase (PDH) in the hearts of Lace1 KO mice.
Estimated human intake of endogenous and exogenous hormones from beef in the United States
Authors: Thilakaratne Ruwan , Castorina Rosemary , Solomon Gina , Mosburg Mary M. , Moeller Benjamin C. , Trott Josephine F. , Falt Tara D. , Villegas-Gomez Ariadne , Dodd Kevin W. , Thomsen Catherine , English Paul , Yang Xiang , Khan Annika , Bradman Asa , Hovey Russell C. 
Published: November 2024

AbstractBackgroundEndogenous and exogenous hormones may be present in beef. Human consumption of hormones has been linked to adverse health effects.ObjectiveTo estimate daily intake of hormonal growth promotants (HGP) from beef consumed by the US population.MethodsWe combined self-reported beef consumption information from a nationally-representative survey with concentrations of 12 HGP measured in 397 samples of retail beef/fat purchased in California. We defined typical, high, and maximum intake scenarios assuming self-reported consumed beef contained the mean, 95thpercentile, and maximum concentrations of each HGP, respectively. We estimated distributions of usual (i.e., long-term) daily intake and short-term daily intake (µg/kg/day). We calculated the hazard quotient (HQ), or ratio of estimated intake to the World Health Organization’s acceptable daily intake (ADI) for the HGP.ResultsThe highest estimated HQs were found for melengestrol acetate (MGA). For usual daily intake under the typical intake scenario, no HQ exceeded 0.02 (0.00047 µg MGA/kg/day). Under the maximum intake scenario, the highest HQ was 0.29 (0.0087 µg MGA/kg/day), corresponding to the 99thpercentile of intake among young boys (ages 1–5). The highest short-term intake estimates for MGA under the maximum intake scenario were the 99thpercentile of intake among young girls and boys, which equaled (HQ = 1.00) or exceeded (HQ = 1.29) the ADI for MGA, respectively.ImpactHormonal growth promotants (HGP) are used to increase beef production and have been linked to adverse reproductive effects. We estimated daily intake of MGA and several other HGP using US nationally-representative beef consumption data collected between 2015–2018 and HGP concentrations in retail beef. Estimated intake was highest for young children, but estimates were generally very low compared to current health-based intake limits. However, these limits are typically based on studies in adult animals, and further study of potential adverse effects during sensitive developmental periods, such as in early life, may be warranted to ensure recommended intake limits are health-protective.