bluuebunny/crossref_metadata_2025_split huggingface dataset:
Immune Checkpoint Inhibitors and the Risk of Allograft Rejection: A Comprehensive Analysis on an Emerging Issue
Authors: Aguirre Luis E. , Guzman Maria E. , Lopes Gilberto , Hurley Judith 
Published: November 2018

AbstractBackgroundIt is well known that the state of immune tolerance induced by broad immunosuppression to prevent allograft rejection leads to an increased risk of the development of cancer. One of the most promising new areas of cancer treatment has been the development of immune checkpoint inhibitors that target the cytotoxic T-lymphocyte-associated antigen 4 and programmed cell death protein 1/programmed death-ligand 1 (PD-L1) pathways. As a logical consequence, growing interest in these agents translated into their implementation in patients with transplant-related malignancies. Because of overlapping and perhaps mutually exclusive mechanisms of action of transplant immunosuppression and cancer immunomodulation, it is critical to examine these interactions.Materials and MethodsWe carried out a systematic search for review articles and case reports published between July 2014 and November 2017 using three engines: Usearch, PubMed, and Up-to-date.ResultsOverall, there were 20 cases with 12 allograft rejections. The rejection rate associated with nivolumab was 73% (8/11) and with pembrolizumab it was 100% (2/2). The use of ipilimumab did not lead to rejection in any instance (0/4, 0%). Of the two patients treated with the sequential use of ipilimumab/nivolumab, one lost his allograft, yielding a rejection rate of 50%. The sequential use of ipilimumab/pembrolizumab led to a rejection rate of 100% (1/1, 100%).ConclusionThe use of agents that act on the PD-L1 pathway are contraindicated in the face of solid organ allografts because of unacceptably high rates of irreversible allograft rejection. It appears that the use of ipilimumab may be tolerated as the mechanism is different from that of the PD-L1 agents.Implications for PracticeTransplant rejection is a complex process that puts stress on patients and their families and can lead to tragic results. Significant advancements in the field of immunosuppression have led to the engenderment of agents devised to extend the survival of transplant recipients. The advent of immunomodulators in cancer therapy has been paradigm-shifting; however, because of their mechanism of action, their use must be carefully considered in patients with allografts and concomitant cancer. It appears that ipilimumab can be administered safely in these patients but that agents acting on the programmed death-ligand 1 pathway are contraindicated because of high rates of irreversible rejection.
“As Long as You Ask”: A Qualitative Study of Biobanking Consent—Oncology Patients’ and Health Care Professionals’ Attitudes, Motivations, and Experiences—the B-PPAE Study
Authors: Yip Sonia , Fleming Jennifer , Shepherd Heather L. , Walczak Adam , Clark Jonathan , Butow Phyllis 
Published: November 2018

Abstract

Introduction
Consent to biobanking remains controversial, with little empirical data to guide policy and practice. This study aimed to explore the attitudes, motivations, and concerns of both oncology patients and health care professionals (HCPs) regarding biobanking.

Materials and Methods
Qualitative interviews were conducted with oncology patients and HCPs purposively selected from five Australian hospitals. Patients were invited to give biobanking consent as part of a clinical trial and/or for future research were eligible. HCPs were eligible if involved in consenting patients to biobanking or to donate specimens to clinical trials.

Results
Twenty-two patients participated, with head and neck (36%) and prostate (18%) the most common cancer diagnoses; all had consented to biobanking. Twenty-two HCPs participated, from across eight cancer streams and five disciplines. Themes identified were (a) biobanking is a “no brainer”; (b) altruism or scientific enquiry; (c) trust in clinicians, science, and institutions; (d) no consent—just do it; (e) respecting patient choice (“opt-out”); (f) respectful timing of the request; (g) need for emotional/family support; (h) context of the biobanking request matters; and (i) factors for biobanking success.

Discussion
These findings reinforced previous findings regarding high public trust in, and support for, biobanking. An initial opt-in consent approach with the option of later opt-out was favored by patients to respect and recognize donor generosity, whereas HCPs preferred an upfront opt-out model. Factors impacting biobanking success included the context of the request for use in a trial or specific research question, pre-existing patient and HCP rapport, a local institution champion, and infrastructure.
Age and the Risk of Paclitaxel-Induced Neuropathy in Women with Early-Stage Breast Cancer (Alliance A151411): Results from 1,881 Patients from Cancer and Leukemia Group B (CALGB) 40101
Authors: Barginear Myra , Dueck Amylou C. , Allred Jacob B. , Bunnell Craig , Cohen Harvey J. , Freedman Rachel A. , Hurria Arti , Kimmick Gretchen , Le-Rademacher Jennifer G. , Lichtman Stuart , Muss Hyman B. , Shulman Lawrence N. , Copur M. Sitiki , Biggs David , Ramaswamy Bhuvaneswari , Lafky Jacqueline M. , Jatoi Aminah 
Published: November 2018

Abstract

Purpose
A few previous studies report a direct relationship between older age and chemotherapy-induced neuropathy. This study further evaluated this adverse event's age-based risk.

Methods
CALGB 40101 investigated adjuvant paclitaxel (80 mg/m2 once per week or 175 mg/m2 every 2 weeks) in patients with breast cancer and served as a platform for the current study that investigated age-based differences in neuropathy. Grade 2 or worse neuropathy, as per Common Terminology Criteria for Adverse Events version 4, was the primary endpoint; patients were assessed at baseline, every 6 months for 2 years, and then annually for 15 years.

Results
Among these 1,881 patients, 230 were 65 years of age or older, 556 were 55–64 years, and 1,095 were younger than 55; 1,226 neuropathy events (commonly grade 1 or 2) were reported in 65% of the cohort. The number of grade 2 or worse events was 63 (27%), 155 (28%), and 266 (24%) within respective age groups (p = .14). In univariate analysis, only motor neuropathy had a higher age-based incidence: 19 (8%), 43 (8%), and 60 (5%), respectively (p = .04); in multivariate analyses, this association was no longer statistically significant. Other endpoints, such as time to onset of neuropathy (time from trial enrollment to neuropathy development) and time to improvement (time from maximal grade sensory neuropathy to a one-category improvement), showed no statistically significant age-based differences. In contrast, obesity was associated with neuropathy, and every 2-week paclitaxel was associated with trends toward neuropathy.

Conclusion
Although paclitaxel-induced neuropathy is common, older age is not an independent risk factor. Clinical trial identification number. NCT00041119 (CALGB 40101).
Meta-analysis of Mitral Valve Repair Versus Replacement for Mitral Valve Infective Endocarditis
Authors: Wang Michael Tzu Min , Haydock Matthew , Pemberton James , Wang Tom Kai Ming 
Published: November 2018

Background: Mitral valve repair has superior results to replacement for severe degenerative mitral valve disease, however in the infective endocarditis setting, mixed results have been reported. We compared the outcomes of mitral valve repair and replacement for infective endocarditis in this meta-analysis.Methods: MEDLINE, Embase and Cochrane databases from 1 January 1980 to 31 December 2015 were searched for original studies. Two authors evaluated these studies for inclusion independently, then data were extracted and pooled.Results: A total of 3,976 papers was obtained from the search, 99 full-texts were reviewed, and 13 studies which included both mitral valve repair and replacement patients involving 8,130 patients were included for analyses. Pooled rates and odds ratio (95% confidence interval) for operative mortality of repair versus replacement were 3.7% vs 10.9%, 0.33 (0.26-0.41). Odds ratio for long term mortality at 1-year (n=4) was 0.31 (0.14-0.72), and at 5 years (n=8) was 0.42 (0.25-0.69). Peri-operative stroke rates and odds ratio (n=4) were 2.8% vs 3.8%, 0.75 (0.55-1.00). Five year recurrent endocarditis and redo-operations (n=6 for both) odds ratios were 0.39 (0.10-1.58) and 0.49 (0.12-2.02) respectively. Similar results were observed when one large study making up 85% of the meta-analysis cohort population was removed.Conclusion: Mitral valve repair is associated with reduction in mortality and stroke, and similar recurrent endocarditis and redo-operation rates compared to mitral valve replacement in mitral valve endocarditis. It is therefore preferred when feasible, similar to surgery for degenerative mitral valve disease.
Synthesis, Anti-Varicella-Zoster Virus and Anti-Cytomegalovirus Activity of 4,5-Disubstituted 1,2,3-(1H)-Triazoles
Authors: Yuan Wei-yuan , Chen Xue , Liu Ning-ning , Wen Yi-ning , Yang Bei , Andrei Graciela , Snoeck Robert , Xiang Yu-hong , Wu Yong-wei , Jiang Zhen , Schols Dominique , Zhang Zhuo-yong , Wu Qin-pei 
Published: November 2018

Background:
Clinical drugs for herpesvirus exhibit high toxicity and suffer from significant
drug resistance. The development of new, effective, and safe anti-herpesvirus agents with
different mechanisms of action is greatly required.

Objective:
Novel inhibitors against herpesvirus with different mechanisms of action from that of
clinical drugs.

Methods:
A series of novel 5-(benzylamino)-1H-1,2,3-triazole-4-carboxamides were efficiently
synthesized and EC50 values against Human Cytomegalovirus (HCMV), Varicella-Zoster Virus
(VZV) and Herpes Simplex Virus (HSV) were evaluated in vitro.

Results:
Some compounds present antiviral activity. Compounds 5s and 5t are potent against both
HCMV and VZV. Compounds 5m, 5n, 5s, and 5t show similar EC50 values against both TK+ and
TK− VZV strains.

Conclusion:
5-(Benzylamino)-1H-1, 2,3-triazole-4-carboxamides are active against herpesviruses
and their activity is remarkably affected by the nature and the position of substituents in the benzene
ring. The results indicate that these derivatives are independent of the viral thymidine kinase
(TK) for activation, which is indispensable for current drugs. Their mechanisms of action may differ
from those of the clinic anti-herpesvirus drugs.
Report of Adverse Events in Colombia: A Successful Case
Authors: Moreno-Mattar Ornella , Ramírez Rosana , Alvarado Andrés , Sierra Francisco , Guzmán Javier 
Published: November 2018

Background:
The Colombian National Food and Drug Surveillance Institute (INVIMA) is
responsible for monitoring the safety and efficacy of medicines circulating the Colombian market.

Discussion:
This article summarizes the three key strategies the institution has implemented to
strengthen the National Pharmacovigilance Program: improving the interaction and working
relationship with regional health authorities, expanding the National Pharmacovigilance Network and
implementing the electronic submission of adverse events.

Conclusion:
The number of adverse events reported in Colombia increased from 5,447 in 2013 to 95,658
in 2017, reaching a population-based reporting ratio within international standards (563 in 2016).
Protein Inter-Residue Contacts Prediction: Methods, Performances and Applications
Authors: Jing Xiaoyang , Dong Qimin , Lu Ruqian , Dong Qiwen 
Published: November 2018

Background:Protein inter-residue contacts prediction play an important role in the field of protein structure and function research. As a low-dimensional representation of protein tertiary structure, protein inter-residue contacts could greatly help de novo protein structure prediction methods to reduce the conformational search space. Over the past two decades, various methods have been developed for protein inter-residue contacts prediction.Objective:We provide a comprehensive and systematic review of protein inter-residue contacts prediction methods.Results:Protein inter-residue contacts prediction methods are roughly classified into five categories: correlated mutations methods, machine-learning methods, fusion methods, templatebased methods and 3D model-based methods. In this paper, firstly we describe the common definition of protein inter-residue contacts and show the typical application of protein inter-residue contacts. Then, we present a comprehensive review of the three main categories for protein interresidue contacts prediction: correlated mutations methods, machine-learning methods and fusion methods. Besides, we analyze the constraints for each category. Furthermore, we compare several representative methods on the CASP11 dataset and discuss performances of these methods in detail.Conclusion:Correlated mutations methods achieve better performances for long-range contacts, while the machine-learning method performs well for short-range contacts. Fusion methods could take advantage of the machine-learning and correlated mutations methods. Employing more effective fusion strategy could be helpful to further improve the performances of fusion methods.
Recent Advances in the Development of Polymeric Nanocarrier Formulations for the Treatment of Colon Cancer
Authors: Kumar Sahil , Sharma Bandna , Thakur Kiran , Bhardwaj Tilak R. , Prasad Deo N. , Singh Rajesh K. 
Published: November 2018

Background:
Many efforts have been explored in the last decade to treat colon cancer but
nanoparticulate drug delivery systems are making a vital contribution in the improvement of drug delivery
to colon cancer cells.

Objective:
In this review, we attempt to highlight recent advancements in the development of novel
drug delivery systems of nanoparticles for the targeted drug delivery to colon. Polymers like Epithelial
Cell Adhesion Molecule (EpCAM) aptamer chitosan, Hyaluronic Acid (HA), Chitosan (CS)–
Carboxymethyl Starch (CMS), silsesquioxane capped mesoporous silica, Near IR (NIR) fluorescent
Human Serum Albumin (HAS), poly(ethylene glycol)-conjugated hyaluronic acid etc. have been discussed
by employing various anticancer drugs like doxorubicin, oxaliplatin, paclitaxel, 5-fluorouracil
etc.

Conclusion:
These novel drug delivery systems have been determined to be more efficacious in terms
of stability, sustained and targeted drug delivery, therapeutic efficacy, improved bioavailability and enhanced
anticancer activity.
THE ROBUSTNESS ASSESSMENT FOR EVENT DRIVEN MOLECULAR DYNAMICS BY CALCULATING SPEED OF SOUND
Authors: AKKAYA Volkan Ramazan , KANDEMİR İlyas 
Published: November 2018

Event-driven molecular dynamics (EDMD) is a special application of Molecular Dynamics (MD) derived from kinetic theory of gases. While classical solution of Navier-Stokes equations fails at high Knudsen (Kn) number flows, EDMD is valid on entire regime. Interaction potentials are considered discrete and exist only at the moment of impact. Hence, molecule trajectories are linear. Unlike the classical MD, this helps to simulate bigger systems. Molecular interactions, interaction times and partners can be predicted deterministically. Diatomic and polyatomic molecules are handled by an implemented energy relaxation scheme. Calculation of possible event times and determination of the earliest are the most time-consuming steps of the simulation. In order to improve computational speed, a cell partitioning methodology and a priority queue structure are implemented in this study. The effect of the implementations on the performance is investigated and optimum simulation parameters are determined; when using PQ, number of cells must be greater than the number of molecules for maximum computational speed. Robustness assessments for the implementations are conducted with a real-world problem. Extreme density difference in confined geometries has vast usage in engineering and is also a good example of stress test because of its complex nature. This paper addresses the calculation of sound speed in a shock tube filled with a diatomic gas by using EDMD simulations. The robustness is validated since the results agrees perfectly with the theoretical values.
İyi ebeveyn, çocuğu için her zaman her şeyi yapan ebeveyn değildir: Algılanan Helikopter Ebeveyn Tutum Ölçeği (AHETÖ) geliştirme çalışması
Authors: Yılmaz Hasan 
Published: November 2018

Helikopter anne baba kavramının 30 yıllık bir geçmişi vardır. Bu çocuk yetiştirme tutumu; anne babanın çocuğu üzerinde aşırı kontrol sağlama çabası, ortada somut sebepler bulunmasa dahi çocuğunun başına gelebilecek herhangi olası bir zarar veya başarısızlığı önlemek için abartılı bir telaş ve çocuğa ihtiyaçlarının ötesinde özveri ile kendini gösterir. Bu araştırmanın amacı, algılanan helikopter ebeveyn tutumunu; anne ve baba düzeyinde etik konular, güven-temel yaşam, akademik yaşam ve duygusal yaşam boyutlarında ölçebilecek geçerli ve güvenilir bir araç üretmektir. Araştırmanın örneklemi 13-45 yaş grubundan 2020 katılımcıdan oluşmaktadır. Veriler üzerinde AFA, DFA ve iç tutarlık katsayıları hesaplanmış ayrıca uyum geçerliğini sınamak için korelasyon katsayıları bulunmuştur. Ölçeğin anne formunun ait uyum endeksleri; Ï‡2/sd= 10,05, RMSEA=0,07, SRMR=0,054, CFI=0,95, NFI=0,94, NNFI= 0,94, GFI=0,91, AGFI=0,90; baba formu için ise; Ï‡2/sd=5,51, RMSEA=0,050, SRMR=0,045, CFI=0,96, NFI=0,95, NNFI=0,95, GFI=0,95, AGFI=0,94 olarak hesaplanmıştır. İç tutarlık katsayıları .85 ve .83’dür. Ayrıca iki ayrı araçla test edilen uyum geçerliliği verileri, her iki form ve dört boyut için yeterli bulunmuştur. Geliştirilen ölçek; araştırmacılar, eğitimciler, çocuk gelişimi uzmanları tarafından, ebeveynlerin anne ve baba düzeyinde helikopter tutumlarını saptayabilecek nitelikleri taşımaktadır.
Oenothera speciosa Nutt. (Onagraceae) en la provincia de Sevilla (España).
Authors: Pulgar Sañudo Íñigo , Ortega Olmo Patricia , Herrera Rodríguez José Manuel 
Published: November 2018

Oenothera speciosa Nutt. (Onagraceae) in the province of Seville (Spain). Palabras clave: Planta adventicia, invasora, nueva cita, Sevilla. Key Words: Adventitious plant, invasive plant, new record, Seville.
Pemanfaatan Limbah Cangkang Kerang Mutiara (Pinctada Maxima) Sebagai Sumber Hidroksiapatit
Authors: Rahayu Susi , Kurniawidi Dian W , Gani Abdul 
Published: November 2018

Pearl shells (pinctada maxima) are the superior commodities in West Nusa Tenggara Province. The shellfish is utilized as a producer of pearls while the waste of pearl shells has not been widely used by the community. Main composition of fhe pearl shells is calcium. CaO content was tested using AAS and obtained CaO in shells as much as 52.23%. CaO is used as a source of hydroxyapatite (HAp). Shellfish powder is synthesized with H3PO4 compound. Synthesis is conducted by precipitation method. Synthesis results were analyzed utilizing XRD and FTIR. From the examination, HAp compounds were identified. Group of PO43, CO32, and OH are constituent groups of HAp compounds. Moreover, another calcium phosphate is formedÃÂ namely TCP. This HAp compound has a maximum crystallinity of 78.33% at an angle of 77.18 ÃÂ°. The smallest HAp particle size at an angle of 31.92 ÃÂ° is 1.4 ÃÂ¼m. The degree of high crystallinity is influenced by high intensity and a wide FWHM. Meanwhile, the small molecule size is acquired on a wide FWHM with a small Bragg angle position.
Alberto Fuguet, Cronista.
Authors: Poblete Alday Patricia 
Published: November 2018

ResumenPOBLETE ALDAY, Patricia. ALBERTO FUGUET, CRONISTA. Lit. lingí¼í­st.[online]. 2013, n.27, pp. 97-110. ISSN 0716-5811. http://dx.doi.org/10.4067/S0716-58112013000100006.Periodista, escritor y cineasta, la de cronista acaso sea la faceta menos conocida del chileno Alberto Fuguet (1964). Este artí­culo propone una mirada a este aspecto de su obra, sobre el criterio de que sus crónicas nos proporcionan un valioso material no sólo para complementar el estudio de sus textos de ficción, sino también y sobre todo, para analizar las relaciones que periodismo y literatura establecen, desde este género, en la época contemporánea. Ello con miras a comprender su actual auge, su revalorización por parte del público y de las editoriales, y su paulatina legitimación como material de estudio académico.
Una comparación de escalas de evaluación por profesores nativos angloparlantes y profesores no nativos angloparlantes.
Authors: Baitman Brittany , Veliz Campos Mauricio 
Published: November 2018

ResumenBAITMAN, Brittany y VELIZ CAMPOS, Mauricio. UNA COMPARACIí“N DE ESCALAS DE EVALUACIí“N POR PROFESORES NATIVOS ANGLOPARLANTES Y PROFESORES NO NATIVOS ANGLOPARLANTES. Lit. lingí¼í­st. [online]. 2013, n.27, pp. 171-200. ISSN 0716-5811. http://dx.doi.org/10.4067/S0716-58112013000100010.Este estudio procura explorar las diferencias y similitudes entre profesores de inglés nativos del idioma (NES del inglés) y profesores de inglés no nativos (NNES del inglés), en relación a su evaluación oral a estudiantes que cursan el mismo nivel universitario. Para ello, se utilizaron dos instrumentos: iBT/Next Generation TOEFL Test Independent Speaking Rubric y un cuestionario. Los resultados revelan que los NESs son menos severos en su evaluación oral en relación a los NNESs. En referencia a los resultados del cuestionario utilizado, éstos revelan que los profesores NES consideran más los aspectos de fluidez y pronunciación en comparación con los NNESs cuando evalúan el desempeño oral de sus estudiantes, mientras que los NNESs enfatizan más la precisión gramatical y el vocabulario. En el área de la evaluación oral aún se requiere mayor investigación, especí­ficamente en relación a la nacionalidad, edad, experiencia laboral y conocimiento de una segunda lengua.
A morte como tema antropológico e teológico
Authors: Oliveira Renato Alves de 
Published: November 2018

A morte é um evento antropológico que gera consequências escatológicas. A teologia clássica desdenhou o tema da morte devido à preocupação com o pós-morte. A definição clássica da morte (separação de corpo e alma) é antropologicamente insuficiente por sua falta de densidade pessoal. O tema da morte, em primeiro lugar, ganhou relevância antropológica com a filosofia contemporânea, principalmente com Heidegger. A morte é uma possibilidade iminente que reside no interior da existência. Da filosofia, o tema da morte passou para teologia protestante e católica e, principalmente sob o influxo de Heidegger, recebeu um tratamento humano. A teoria da “decisão final”, expressão da antropologia da morte, concentrou sua atenção sobre o que ocorreria com as relações entre o corpo e a alma no momento pontual da morte. Abstract: Death is an anthropological event that leads to eschatological consequences. Classical theology dismissed the theme of death in view of its concern with the afterlife. The classic definition of death (the separation of body and soul) is anthropologically insufficient because of its lack of personal density. The theme of death gained anthropological relevance for the first time with contemporary philosophy, especially with Heidegger. Death is an imminent possibility that lies within the existence. From philosophy the theme of death passed into Protestant and Catholic theology and especially under Heidegger’s influence, received a humane treatment. The theory of “final decision”, an expression of the anthropology of death, focused its attention on what would happen with the relationship between body and soul at the actual time of death.Keywords: Life. Death. Anthropology. Imminent possibility. Term-realization.