bluuebunny/crossref_metadata_2025_split huggingface dataset:
Une épistémologie qui fait part belle à la liberté du sujet : la cardiophénoménologie dans le creuset créateur de la neurophénoménologie
Authors: Depraz Nathalie 
Published: July 2018

Les (neuro)sciences, dans leur pratique et leur théorie objectivantes en troisième personne, semblent imperméables à la question de la liberté du sujet. Seule une approche scientifique-épistémologique qui inclut « la première personne » à titre de composante interne de leur méthodologie a une chance de faire « bouger les lignes » de l’objectivité réductionniste dominante. C’est le pari de la neurophénoménologie, dont nous montrerons quelle figure de la liberté du sujet incarné-énactif elle promeut et, à sa suite, de la cardiophénoménologie, qui en radicalise le programme, avec la figure d’un sujet cardial (cardiaque-affectif).
IL-7 Enables Antibody Responses to Bacterial Polysaccharides by Promoting B Cell Receptor Diversity
Authors: Dickinson Gregory S. , Levenson Eric A. , Walker Justin A. , Kearney John F. , Alugupalli Kishore R. 
Published: July 2018

Abstract
Polysaccharide vaccines such as the Vi polysaccharide (ViPS) of Salmonella enterica serovar Typhi induce efficient Ab responses in adults but not in young children. The reasons for this difference are not understood. IL-7 dependency in B cell development increases progressively with age. IL-7Rα–mediated signals are required for the expression of many VH gene segments that are distal to DH–JH in the IgH locus and for the complete diversification of the BCR repertoire. Therefore, we hypothesized that B cells generated in the absence of IL-7 do not recognize a wide range of Ags because of a restricted BCR repertoire. Compared with adult wildtype mice, young wildtype mice and IL-7–deficient adult mice generated a significantly reduced Ab response to ViPS. Additionally, ViPS-binding B cells in adult wildtype mice predominantly used distal VH gene segments. Transgenic expression of either IL-7 or a BCR encoded by a distal VH gene segment permitted young mice to respond efficiently to bacterial polysaccharides. These results indicate that restricted VH gene usage early in life results in a paucity of Ag-specific B cell precursors, thus limiting antipolysaccharide responses.
Effect of valproic acid on survival in glioblastoma: A prospective single-arm study
Authors: Valiyaveetti Deepthi , Malik Monica , Joseph Deepa M. , Ahmed Syed Fayaz , Kothwal Syed Akram , Vijayasaradhi M. 
Published: July 2018

Abstract
Background: Retrospective evidence suggests that valproic acid (VPA), an antiepileptic drug, is associated with improved outcomes in glioblastoma. The exact mechanism of interaction of VPA with radiation and temozolomide (TMZ) is still unclear. Laboratory studies show that VPA can enhance tumor cell kill while at the same time protect the normal neural tissue. The aim of this study was to prospectively evaluate the benefit of VPA on outcomes in glioblastoma. Materials and Methods: In this single-arm prospective study, patients of glioblastoma were started on seizure prophylaxis with VPA (15–20 mg/kg/day) following maximal safe resection. All patients were treated with chemoradiation to a dose of 60 Gy in 30 fractions with concurrent TMZ followed by adjuvant TMZ for 6 cycles. VPA was continued during adjuvant treatment and follow-up. Survival analysis was done using Kaplan–Meier analysis. Results: Twenty patients were enrolled in the study. Median age was 47 years. M:F ratio was 3:1. Treatment was well tolerated with no grade 3/4 adverse events. 8/20 patients experience seizure episodes during treatment and/or follow-up which needed additional antiepileptic drugs for control. Median progression-free survival (PFS) and overall survival (OS) were 10 months and 16 months, respectively. Younger patients (age ≤45 years) showed a significantly better OS (25 months) versus older patients (8 months) (P = 0.002). Conclusions: Incidence of seizures on VPA prophylaxis was 40%. Median PFS and OS were comparable to historical controls. There was no significant treatment-related toxicity. The results need validation in larger prospective randomized studies.
conversando con...EMILIO TUÑÓN (parte 2): Dibujar para entender II. La mano que piensa, procesa, construye
Authors: Raposo Grau Javier Francisco , Salgado de la Rosa Mariasun , Butragueño Díaz-Guerra Belén 
Published: July 2018

<p>A lo largo de esta entrevista, hemos podido comprobar que Emilio Tuñón, ahora en solitario como arquitecto, al frente de la firma Tuñón Arquitectos, y durante muchos años en compañía de su socio Luis Moreno Mansilla, ambos al frente de la firma Mansilla + Tuñón Arquitectos, son profesionales de alto nivel profesional y humano. </p><p>De la entrevista realizada a Emilio Tuñón podemos destacar la perfecta articulación de sus contenidos a las respuestas formuladas en relación a la disciplina del dibujar, la coherencia de su discurso, nada improvisado, sino profundo y de convicción madura, y su amabilidad y generosidad en cuanto a sus comentarios, siempre con una mirada hacia la disciplina del dibujar como modo de pensar, procesar y construir un lenguaje, que nos hace capaces de entender el mundo que nos rodea… de entender el dibujar como una manifestación natural de extensión de la mano, del ojo, de la cabeza…</p><p>(Esta entrevista es continuación de la primera parte publicada en el número 32 de la Revista EGA)</p>
From virtual to real. A wood model for the philological reconstruction of the Alessandrino district, in the Central Archaeological Area of Rome
Authors: Calisi Daniele , Cianci Maria Grazia 
Published: July 2018

<p>Esta contribución muestra el resultado de años de investigación del Departamento de Arquitectura de Roma Tre sobre la reconstrucción virtual del barrio Alessandrino, demolido para favorecer la Via dell’Impero en los años 30. El estudio de los documentos de archivo, la digitalización, la reconstrucción de un modelo virtual muy detallado, y la búsqueda de las fuentes y de las fotografías históricas han confluido en el esfuerzo de realizar una maqueta de madera para el Museo di Roma, gracias a las continuas relaciones culturales con la <em>Soprintendenza Capitolina</em>.</p>
Reseña de Morant, R. y Martínez López, A. (2017). Tatuajes urbanos: los susurros, murmullos y gritos de la ciudad. Valencia: Tirant Humanidades
Authors: Pérez Ródenas Sandra 
Published: July 2018

Cuando viajamos a una nueva ciudad somos capaces de percibir que en algún aspecto ésta dista de nuestra ciudad de origen. Esto se debe a que las ciudades son capaces de transmitir mensajes a los seres humanos, tanto a partir de elementos no verbales como a partir de elementos verbales. De esta capacidad comunicativa de las ciudades se han percatado los autores de este libro, los cuales analizan en esta obra una serie de mensajes localizados en suelos, muros, mobiliario urbano, pancartas en balcones e incluso en la vestimenta de los conciudadanos (es decir, en espacios públicos de la ciudad de Valencia y otros municipios valencianos).
Dual-task exercise as a therapy for executive motor function in Parkinson’s disease
Authors: de Assis Gilmara Gomes , da Silva Tatiane Alves , Dantas Paulo Moreira Silva 
Published: July 2018

PurposeTo evaluate the effects of aerobic exercise with dual-task on the motor function in patients with Parkinson’s disease.MethodsClinically evaluated by the Unified Parkinson’s Disease Rating Scale – III and the Senior Fitness Test battery, 20 patients with Parkinson’s disease were randomly divided into a control and an experimental group, with the latter performing a 4-week program of water-walking in a deep pool while executing dual-tasks. Evaluations were made before and after 4 weeks in both groups.ResultsPatients with Parkinson’s disease revealed significant improvements in pre-/post-exercise motor function, with a moderate effect (<i>p</i> < 0.001; <i>d</i> = 0.44). Bradykinesia (<i>p</i> < 0.001) and agility (<i>p</i> < 0.001) exhibited significant changes individually.ConclusionsRegular exercise combined with executive challenge such as dual-task may counteract the advanced motor symptoms of Parkinson’s disease neurodegeneration.
Agreement between body mass index and the sum of skinfolds in adolescents with different levels of physical activity
Authors: Pelegrini Andreia , Pinto Andre de Araujo , Petroski Edio Luiz 
Published: July 2018

PurposeThe purpose of this study was to examine the agreement between body mass index and body fat estimate among adolescents with different physical activity (PA) levels, using the sum of skinfolds as our criterion.MethodsThis was a cross-sectional study with 732 adolescent participants (63.4% of which were female), with an average age of 16.1 (±1.1) years old. The reference method used to estimate the body fat was the sum of triceps and subscapular skinfolds. BMI was calculated using body mass and height values. The PA was estimated using the International Physical Activity Questionnaire - IPAQ (short version). Bland-Altman diagrams were used to evaluate the agreement between BMI and the sum of skinfolds and were transformed into a Z score.ResultsFor males, BMI overestimated body fat among those who did (mean error = -0.67; <i>p</i> < 0.001) and those who did not (mean error = -0.45; <i>p</i> < 0.001) meet the recommended PA values with a greater error observed for those who met PA recommendations. For females, BMI underestimated body fat among those who met (mean error = 0.29; <i>p</i> < 0.001) and did not meet (mean error = 0.41; <i>p</i> < 0.001) the recommended PA values with a greater error observed for those who did not meet recommendations.ConclusionsCompared to sum of skinfolds, there was weak agreement between BMI and body fat among adolescents, especially among those with higher or lower PA levels. The use of other methods to estimate body fat in such cases is strongly recommended.
Health behaviors of amateur mountain bike athletes
Authors: Gruszczynska Magdalena , Bak-Sosnowska Monika , Plinta Ryszard 
Published: July 2018

PurposeThe aim of the study was to characterize health behaviors of amateur mountain biking marathon participants.MethodsThe study included 819 participants of amateur mountain biking marathons in Poland, 82.17% of whom were male and 17.83% were female. The average age of the participants was 34.85 ± 8.7 years. The tools used in the study were Juszczyński’s Inventory of Health Behaviors (IHB) and an original survey form.ResultsMore than half of the participants (58.49%) displayed pro-health behaviors. The study showed a statistically significant correlation between pro-health behaviors and interpersonal status (<i>p</i> = 0.036), having children (<i>p</i> = 0.013), age (<i>p</i> = 0.031), and time devoted to training (<i>p</i> = 0.003).ConclusionsA majority of mountain biking marathon participants display pro-health behaviors. Promoting pro-health practices and prophylactic measures among people playing sports as a form of recreation should be paid attention to.
A single session of active video game play promotes post-exercise hypotension in hypertensive middle-aged subjects
Authors: Silva Taís Feitosa da , França Ana Carla Lima de , Souza Marizângela Ferreira de , Silva Alexandre Sérgio 
Published: July 2018

PurposeTo determine whether an active video game session promoted post-exercise hypotension, similar to walking.MethodsFifteen hypertensive subjects (49.0 ± 1.6 years) of both genders performed five randomized sessions, lasting 60 minutes: 1) active video game; 2) sedentary video game; 3) walking on a treadmill with moderate intensity; 4) walking on a treadmill with similar intensity to the active video game; and 5) control without exercise. Blood pressure and cardiac autonomic modulation measurements were taken at rest and every 10 minutes post exercise for 60 minutes.ResultsThe active video game promoted a reduction in systolic blood pressure (-14.4 ± 3.0 mmHg, <i>p</i> < 0.0001) similar to walking on a treadmill with moderate intensity (-16.9 ± 3.3 mmHg, <i>p</i> < 0.0001), whereas the control group without exercise did not demonstrate a blood pressure reduction. The sedentary video game also demonstrated a reduction in systolic blood pressure (-10.0 ± 3.1 mmHg, <i>p</i> = 0.0039), statistically similar to the active video game and walking on a treadmill with similar intensity to the active video game (8.7 ± 2.9 mmHg, <i>p</i> = 0.0034). Regarding the diastolic component, the active video game (-7.6 ± 1.5 mmHg, <i>p</i> < 0.0001), walking on a treadmill with moderate intensity (-8.3 ± 2.9 mmHg, <i>p</i> = 0.0042), and the sedentary video game (-7.5 ± 2.7 mmHg, <i>p</i> = 0.0098) produced similar reductions in diastolic blood pressure. The active video game was a procedure that promoted a sympathetic-vagal balance reduction from pre-exercise to 60 minutes post exercise (4.2 ± 0.8 to 2.3 ± 0.5, <i>p</i> = 0.0486).ConclusionsActive video game play promoted a similar reduction in blood pressure compared to traditional walking exercise with the advantage of promoting reduction in the sympathetic inflow to the heart.
Effects of training versus short exercise session on homocysteine levels in women with different body mass
Authors: Murawska-Cialowicz Eugenia , Zuwala-Jagiello Jolanta 
Published: July 2018

PurposeHomocysteine is a non-protein amino acid and elevated blood levels are often caused by inappropriate lifestyles, leading to atherosclerosis and cardiovascular diseases. The aim of this study was to determine the levels of homocysteine after a 9-month training program.MethodsThe group studied consisted of obese and overweight women, as well as women with normal body mass. During the training program, control examinations were carried out four times and the following parameters were analyzed: homocysteine blood levels, body mass, BMI, a single 10-minute exercise at a workload of 100W and the VO2max measured using the Astrand–Ryhming method.ResultsThe highest homocysteine levels were found in obese women and the lowest in lean women. Higher levels were observed in older women (aged over 50 years) compared to younger women (aged below 50 years). The differences were clearly visible in obese women. Homocysteine levels decreased after the 9-month training program. A single exercise performed every three months during the training program resulted in an increase in homocysteine levels or no changes.ConclusionsHigher homocysteine levels in the blood after a single exercise are likely caused by faster metabolism of this amino acid. Exercise of moderate intensity leads to a decrease in homocysteine levels in the blood, especially in obese women. Regular physical activity should therefore be recommended not only to prevent and treat obesity but, most importantly, atherosclerosis.
Testing the Effectiveness of a Short-Term Stress Prevention Programme in Primary School Students
Authors: Englert Chris , Bechler Aline , Singh Sarah , Bertrams Alex 
Published: July 2018

The present study tested the effectiveness of a four-week, school-based, universal cognitive-behavioural stress prevention programme. The prevention programme included short daily exercises which were adopted from two well-validated anti stress trainings. The daily exercises took approximately 10−15 minutes on average and were performed during regular classroom sessions. Half of the classes were randomly assigned to the prevention group (n = 80), while the other half were sorted into the non-treatment control group, which did not take part in the stress prevention programme (n = 73). The students’ physical and psychological stress-related symptoms were assessed five times (i.e., prior to the training and after each week of training). Their coping strategies, self-efficacy and self-control were also measured. It was hypothesized that in the prevention group students’ physical and psychological stress-related symptoms would significantly decrease over time, compared to the non-treatment control group. Contrary to our predictions, the prevention programme did not lead to statistically significant changes in physical or psychological stress-related symptoms. The students’ coping strategies, self-efficacy and self-control did not have an influence on the result patterns. The results indicate that short-term stress prevention programmes may not be as effective as long-term programmes.
O olhar por diferentes lentes: o Photovoice enquanto método científico participativo
Authors: Souza Daniel Meirinho 
Published: July 2018

Este artigo intenciona promover uma reflexão teórica em torno da aplicabilidade e usos da fotografia participativa abordada pelo método Photovoice, contextualizando a importância da imagem fotográfica enquanto ferramenta metodológica em pesquisas sociais e colaborativas. Por fim, levantaremos um debate acerca dos benefícios e potenciais da metodologia Photovoice, assim como alguns dilemas, desafios e limitações da fotografia participativa como ferramenta de pesquisa-ação.
A CAVERNA DE PLATÃO EM TRÊS ATOS
Authors: Costa Rugnitz Natalia 
Published: July 2018

O texto que segue tem como objetivo ensaiar uma reconstrução dramática da Alegoria da Caverna, presente no sétimo livro da República de Platão. Proporemos uma divisão em três atos, sendo o primeiro composto pela descrição (i) do lugar da encenação como uma prisão e (ii) a condição das personagens como prisioneiros; o segundo, composto pela descrição (i) da instância de libertação de um dos cativos e (ii) dos avatares do caminho para fora da caverna por ele percorrido; o terceiro, composto pela descrição do processo que leva à volta à caverna. Proporemos, nesta base, um esboço do arco de transformação da personagem do prisioneiro liberado na sequência (i) prisioneiro, (ii) liberto, (iii) sujeito esclarecido, (iv) redentor e, finalmente, (v) mártir. Sugeriremos a existência de (i) dois pontos de giro da trama e (ii) dois deus ex machina, procurando destacar o caráter trágico da construção.
GÊNERO E VIOLÊNCIA SIMBÓLICA: UM ESTUDO INTRODUTÓRIO SOBRE O SER DA MULHER E OS PAPÉIS CONSTRUÍDOS EM SOCIEDADE
Authors: Ferreira Júnior Agnaldo Paulino 
Published: July 2018

Esse estudo busca analisar o papel da mulher na sociedade Moderna e meados da Idade Contemporânea no que diz respeito ao estado de ser mulher. Embasados em pontos de vista histórico analítico, se faz necessário analisar os aspectos históricos das épocas em questão, para assim, pode entender o local (social) no qual as mulheres foram inseridas. Entendendo o papel da mulher como uma forma de alienação conjugal, social e política, que visava o empoderamento patriarcal em detrimento de uma submissão feminina, este estudo também tem a finalidade de demonstrar a violência simbólica constituída a partir de caracteres não materiais, mas através de discursos e enculturamento arbitrariamente sexistas. Será possível considerar, como já falado por tantos autores, que não existem diferenças corporais ou intelectuais que coloquem a mulher em situação de sujeição. O lugar do bode expiatório poderia ser atribuído a qualquer grupo na tentativa de “minimizar” ou “justificar” as tensões e incertezas da não possibilidade de realização de desejo de outros grupos. Tendo essas questões postas, de maneira introdutória, espera-se que este estudo possa contribuir no adensamento das ações de enfrentamento relacionadas a violência simbólica e de gênero.Esse estudo busca analisar o papel da mulher na sociedade Moderna e meados da Idade Contemporânea no que diz respeito ao estado de ser mulher. Embasados em pontos de vista histórico analítico, se faz necessário analisar os aspectos históricos das épocas em questão, para assim, pode entender o local (social) no qual as mulheres foram inseridas. Entendendo o papel da mulher como uma forma de alienação conjugal, social e política, que visava o empoderamento patriarcal em detrimento de uma submissão feminina, este estudo também tem a finalidade de demonstrar a violência simbólica constituída a partir de caracteres não materiais, mas através de discursos e enculturamento arbitrariamente sexistas. Será possível considerar, como já falado por tantos autores, que não existem diferenças corporais ou intelectuais que coloquem a mulher em situação de sujeição. O lugar do bode expiatório poderia ser atribuído a qualquer grupo na tentativa de “minimizar” ou “justificar” as tensões e incertezas da não possibilidade de realização de desejo de outros grupos. Tendo essas questões postas, de maneira introdutória, espera-se que este estudo possa contribuir no adensamento das ações de enfrentamento relacionadas a violência simbólica e de gênero.
SOCIEDADE DO CANSAÇO
Authors: Bontempo Valéria Lima 
Published: July 2018

A obra aborda como o mundo ocidental, contemporâneo, está se tornando uma sociedade do cansaço. Sua lógica é maximizar o desempenho de seus indivíduos que chegam a se autoexplorar e expressam uma sére de doenças decorrentes desse processo.
LIMITES DA TOLERÂNCIA E LIBERDADE DE EXPRESSÃO: CONSIDERAÇÕES À LUZ DO PENSAMENTO DE JOHN RAWLS EM UMA TEORIA DA JUSTIÇA
Authors: Cunha Wanderley Martins 
Published: July 2018

O escopo principal deste texto — tendo como pressuposto a necessidade de assinalar as margens para além das quais a tolerância torna-se indiferença, passividade ou cumplicidade com o intolerável, conforme assinala Paul Ricoeur — é abordar, à luz da teoria da justiça como eqüidade de John Rawls, a problemática da justificativa para a intolerância e dos limites da tolerância e sua incidência no âmbito da liberdade de expressão.
Ion Transport at the Plant Plasma Membrane
Authors: Wang Yizhou , Blatt Michael R , Chen Zhong‐Hua 
Published: July 2018

Abstract

Membrane transport plays a fundamental role in virtually every aspect of homeostasis, signalling, growth and development in plants. At the plasma membrane, the boundary with the outside world, ion and solute fluxes underpin inorganic mineral nutrient uptake, they trigger rapid changes in second messengers such as cytosolic‐free Ca
2+
concentrations and they power the osmotic gradients that drive cell expansion, to name just a few roles. Our understanding of the transporters – the ion pumps that generate an H
+
electrochemical driving force, H
+
ion‐coupled symport and antiport systems and ion channels – now, more than ever, builds on developments in molecular genetics, genomics, protein chemistry and crystallography to gain insights into the fine structure and mechanics of these remarkable enzymes. Even so, it is the interface with the biophysical detail of ion transport that drives scientific enquiry in the field and will continue to be essential in informing both the most fundamental research as well as efforts to apply the knowledge gained in resolving some of the dilemmas that face society today.

Key Concepts

Study of ion transport is the key for our understanding of mineral nutrition in plants.

Ion transporters and their biophysical properties form the basis for understanding of the membrane potentials.

Plasma membrane H
+
‐ATPase of plants and the Na
+
/K
+
‐ATPase of animals are both members of the P‐type membrane ATPase superfamily.

The transport of many solutes is coupled by H
+
across plasma membrane of plant cells.

Ion channels carry much larger current than pumps and cotransporters on a unit protein basis.

Membrane vesicle traffic regulates ion transport by controlling the population and availability of transporters at the membrane and, in some cases, by direct binding with ion transporters.

Plasma membrane ion transporters have coevolved with the evolution of land plants.