bluuebunny/crossref_metadata_2025_split huggingface dataset:
Venous Thromboembolism in Upper Extremity Fractures
Authors: Nayar Suresh K. , Kuwabara Anne M. , Flores José M. , Osgood Greg M. , LaPorte Dawn M. , Shafiq Babar 
Published: October 2018

Background: Venous thromboembolism (VTE) has been studied in lower extremity fractures but little is known of its relation with upper extremity (UE) fractures. As an often overlooked but serious complication, VTE may compromise patient outcomes.Methods: Using data on inpatients (aged ≥ 18 years) at a level-I trauma center and patients in the National Surgical Quality Improvement Program database who sustained UE fractures (clavicle, humerus, or radius/ulna) and VTE in the same hospitalization between 2007 and 2014, the authors analyzed data on demographic characteristics, fracture type, VTE location (pulmonary embolism, lower extremity, or UE), VTE onset, polytrauma, operative or nonoperative management, comorbidities, and mortality.Results: Of 1984 inpatients with UE fractures at 1 instution, 9 experienced VTE on admission, and 17 (15 received thromboprophylaxis) experienced VTE during hospitalization, for an overall VTE rate of 1.3%. VTE occurred most often in patients with fractures of the proximal humerus (3.0%) followed by the clavicle (2.0%), midshaft humerus (1.9%), distal radius/ulna (0.95%), and distal humerus/elbow (0.36%) (p = 0.0035). There were no significant trends in the incidence of PE (p = 0.33) over the study period, but there was a sharp rise since 2011. In the national database, 42 of 11570 (0.36%) patients with UE fracture had VTE, with incidence by fracture location ranging from 0.14% (radius/ulna) to 0.98% (proximal humerus) (p = 0.00001). Predictors were chronic steroid use (odds ratio [OR] = 6.22, p = .030), inpatient status (OR = 4.09, p = .002), and totally disabled functional status (OR = 3.31, p = .021).Conclusions: VTE incidence was highest following proximal humerus or clavicle fractures and are rarely associated with radius/ulna fractures. There may have been a rise in the incidence of PE since 2007, warranting further investigation.
Is Pseudomeningocele an Absolute Sign of Root Avulsion Brachial Plexus Injury?
Authors: Laohaprasitiporn Panai , Wongtrakul Saichol , Vathana Torpon , Limthongthang Roongsak , Songcharoen Panupan 
Published: October 2018

Background: The finding of pseudomeningocele from cervical myelogram is widely accepted as a pathognomonic sign for diagnosing root avulsion in brachial plexus injury. In general, motor power in this setting should be absent. However, in clinical practice, we observed that motor power in some patients was still preserved. The objective of this study is to evaluate the accuracy of pseudomeningocele from cervical myelogram for predicting root avulsion in brachial plexus injury.Methods: We retrospectively reviewed 201 patients with brachial plexus injury from 2007–2011. Four patients were excluded due to open wound injury. Motor power of the key muscle of each nerve root was evaluated by skilled hand surgeons. All cervical myelogram was interpreted by radiologists. Sensitivities, specificities, positive predictive values and negative predictive values were calculated with 95% confidence interval.Results: Thirty and 29% of pseudomeningocele occurred at C7 and C8 level, respectively. The sensitivity of pseudomeningocele of each root from C5 to T1 was low (range, 10–62%). The specificity was high only at C5 (91%) and T1 (96.2%). Over 20% of patients with pseudomeningocele at C6–8 levels had some motor function. The initial muscle power of these patients was M1 or M2 and 70% of them recovered to at least M3 at the final follow-up.Conclusions: Pseudomeningocele is not an absolute sign for diagnosing of root avulsion in brachial plexus injury due to its high false positive rate when compared with preoperative motor function of each root. Careful examination of the key muscle of each root is extremely crucial to prevent unnecessary operation on that cervical nerve root.
Measuring and interpreting CO
2
fluxes at regional scale: the case of the Apennines, Italy
Authors: Frondini Francesco , Cardellini Carlo , Caliro Stefano , Beddini Giulio , Rosiello Angelo , Chiodini Giovanni 
Published: October 2018

Tectonically active regions are often characterized by large amounts of carbon dioxide degassing, and estimation of the total CO
2
discharged to the atmosphere from tectonic structures, hydrothermal systems and inactive volcanic areas is crucial for the definition of present-day global Earth degassing. The carbon balance of regional aquifers is a powerful tool to quantify the diffuse degassing of deep inorganic carbon sources because the method integrates the CO
2
flux over large areas. Its application to peninsular Italy shows that the region is characterized by specific CO
2
fluxes higher than the baseline determined for the geothermal regions of the world, and that the amount of endogenous CO
2
discharged through diffuse regional degassing (
c
. 2.1 × 10
11
mol a
−1
) is the major component of the geological CO
2
budget of Italy, definitely prevailing over the CO
2
discharged by Italian active volcanoes and volcanoes with hydrothermal activity. Furthermore, the positive correlation between geothermal heat and deep CO
2
dissolved in the groundwater of central Italy suggests that (1) the geothermal heat is transported into the aquifers by the same hot CO
2
-rich fluids causing the Italian CO
2
anomaly and (2) the advective heat flow is the dominant form of heat transfer of the region.

Supplementary material:
The location, flow rate, extent of the hydrogeological basin, chemical and isotopic analyses of the 160 springs considered in this study, and the results of the carbon mass balance are reported in a table available at
https://doi.org/10.6084/m9.figshare.c.4237025
Arterial blood sampling in male CD-1 and C57BL/6J mice with 1% isoflurane is similar to awake mice
Authors: Loeven Ashley M. , Receno Candace N. , Cunningham Caitlin M. , DeRuisseau Lara R. 
Published: October 2018

Isoflurane (ISO) is a commonly used anesthetic that offers rapid recovery for laboratory animal research. Initial studies indicated no difference in arterial Pco2([Formula: see text]) or pH between conscious (NO ISO) and 1% ISO-exposed CD-1 mice. Our laboratory investigated whether arterial blood sampling with 1% ISO is a suitable alternative to NO ISO sampling for monitoring ventilation in a commonly studied mouse strain. We hypothesized similar blood chemistry, breathing patterns, and cardiovascular responses with NO ISO and 1% ISO. C57BL/6J mice underwent unrestrained barometric plethysmography to quantify the pattern of breathing. Mice exposed to hypoxic and hypercapnic gas under 1% ISO displayed blunted responses; with air, there were no breathing differences. Blood pressure and heart rate were not different between NO ISO and 1% ISO-exposed mice breathing air. Oxygen saturation was not different between groups receiving 2% ISO, 1% ISO, or air. Breathing frequency stabilized at ~11 min of 1% ISO following 2% ISO exposure, suggesting that 11 min is the optimal time for a sample in C57BL/6J mice. Blood samples at 1% ISO and NO ISO revealed no differences in blood pH and [Formula: see text] in C57BL/6J mice. Overall, this method reveals similar arterial blood sampling values in awake and 1% ISO CD-1 and C57BL/6J mice exposed to air. Although this protocol may be appropriate in other mouse strains when a conscious sample is not feasible, caution is warranted first to identify breathing frequency responses at 1% ISO to tailor the protocol.NEW & NOTEWORTHY Conscious arterial blood sampling is influenced by extraneous factors and is a challenging method due to the small size of mice. Through a series of experiments, we show that arterial blood sampling with 1% isoflurane (ISO) is an alternative to awake sampling in C57BL/6J and CD-1 male mice breathing air. Monitoring breathing frequency during 1% ISO is important to the protocol and should be closely followed to confirm adequate recovery after the catheter implantation.
The Juggler of Notre Dame and the Medievalizing of Modernity
Authors: Ziolkowski Jan M. 
Published: October 2018

This ambitious and vivid study in six volumes explores the journey of a single, electrifying story, from its first incarnation in a medieval French poem through its prolific rebirth in the nineteenth and twentieth centuries. The Juggler of Notre Dame tells how an entertainer abandons the world to join a monastery, but is suspected of blasphemy after dancing his devotion before a statue of the Madonna in the crypt; he is saved when the statue, delighted by his skill, miraculously comes to life.
Jan Ziolkowski tracks the poem from its medieval roots to its rediscovery in late nineteenth-century Paris, before its translation into English in Britain and the United States. The visual influence of the tale on Gothic revivalism and vice versa in America is carefully documented with lavish and inventive illustrations, and Ziolkowski concludes with an examination of the explosion of interest in The Juggler of Notre Dame in the twentieth century and its place in mass culture today. Volume 4 examines the famous Le jongleur de Notre Dame by the French composer Jules Massenet, which took Europe by storm after premiering in 1902 and then crossed the Atlantic to the impresario Oscar Hammerstein and the diva Mary Garden, who gave the opera new legs as a female juggler.
Presented with great clarity and simplicity, Ziolkowski's work is accessible to the general reader, while its many new discoveries will be valuable to academics in such fields and disciplines as medieval studies, medievalism, philology, literary history, art history, folklore, performance studies, and reception studies.
100 Years of Progress in Polar Meteorology
Authors: Walsh John E. , Bromwich David H. , Overland James. E. , Serreze Mark C. , Wood Kevin R. 
Published: October 2018

AbstractThe polar regions present several unique challenges to meteorology, including remoteness and a harsh environment. We summarize the evolution of polar meteorology in both hemispheres, beginning with measurements made during early expeditions and concluding with the recent decades in which polar meteorology has been central to global challenges such as the ozone hole, weather prediction, and climate change. Whereas the 1800s and early 1900s provided data from expeditions and only a few subarctic stations, the past 100 years have seen great advances in the observational network and corresponding understanding of the meteorology of the polar regions. For example, a persistent view in the early twentieth century was of an Arctic Ocean dominated by a permanent high pressure cell, a glacial anticyclone. With increased observations, by the 1950s it became apparent that, while anticyclones are a common feature of the Arctic circulation, cyclones are frequent and may be found anywhere in the Arctic. Technology has benefited polar meteorology through advances in instrumentation, especially autonomously operated instruments. Moreover, satellite remote sensing and computer models revolutionized polar meteorology. We highlight the four International Polar Years and several high-latitude field programs of recent decades. We also note outstanding challenges, which include understanding of the role of the Arctic in variations of midlatitude weather and climate, the ability to model surface energy exchanges over a changing Arctic Ocean, assessments of ongoing and future trends in extreme events in polar regions, and the role of internal variability in multiyear-to-decadal variations of polar climate.
Climate and the Global Famine of 1876–78
Authors: Singh Deepti , Seager Richard , Cook Benjamin I. , Cane Mark , Ting Mingfang , Cook Edward , Davis Michael 
Published: October 2018

AbstractFrom 1875 to 1878, concurrent multiyear droughts in Asia, Brazil, and Africa, referred to as the Great Drought, caused widespread crop failures, catalyzing the so-called Global Famine, which had fatalities exceeding 50 million people and long-lasting societal consequences. Observations, paleoclimate reconstructions, and climate model simulations are used 1) to demonstrate the severity and characterize the evolution of drought across different regions, and 2) to investigate the underlying mechanisms driving its multiyear persistence. Severe or record-setting droughts occurred on continents in both hemispheres and in multiple seasons, with the “Monsoon Asia” region being the hardest hit, experiencing the single most intense and the second most expansive drought in the last 800 years. The extreme severity, duration, and extent of this global event is associated with an extraordinary combination of preceding cool tropical Pacific conditions (1870–76), a record-breaking El Niño (1877–78), a record strong Indian Ocean dipole (1877), and record warm North Atlantic Ocean (1878) conditions. Composites of historical analogs and two sets of ensemble simulations—one forced with global sea surface temperatures (SSTs) and another forced with tropical Pacific SSTs—were used to distinguish the role of the extreme conditions in different ocean basins. While the drought in most regions was largely driven by the tropical Pacific SST conditions, an extreme positive phase of the Indian Ocean dipole and warm North Atlantic SSTs, both likely aided by the strong El Niño in 1877–78, intensified and prolonged droughts in Australia and Brazil, respectively, and extended the impact to northern and southeastern Africa. Climatic conditions that caused the Great Drought and Global Famine arose from natural variability, and their recurrence, with hydrological impacts intensified by global warming, could again potentially undermine global food security.
Gremlin 1 blocks vascular endothelial growth factor signaling in the pulmonary microvascular endothelium
Authors: Rowan Simon C. , Piouceau Lucie , Cornwell Joanna , Li Lili , McLoughlin Paul 
Published: October 2018

The bone morphogenetic protein (BMP) antagonist gremlin 1 plays a central role in the pathogenesis of hypoxic pulmonary hypertension (HPH). Recently, non‐canonical functions of gremlin 1 have been identified, including specific binding to the vascular endothelial growth factor receptor‐2 (VEGFR2). We tested the hypothesis that gremlin 1 modulates VEGFR2 signaling in the pulmonary microvascular endothelium.We examined the effect of gremlin 1 haploinsufficiency on the expression of VEGF responsive genes and proteins in the hypoxic (10% O2) murine lung in vivo. Using human microvascular endothelial cells in vitro we examined the effect of gremlin 1 on VEGF signaling.Gremlin 1 haploinsufficiency (Grem1+/–) attenuated the hypoxia‐induced increase in gremlin 1 observed in the wild‐type mouse lung. Reduced gremlin 1 expression in hypoxic Grem1+/– mice restored VEGFR2 expression and endothelial nitric oxide synthase (eNOS) expression and activity to normoxic values. Recombinant monomeric gremlin 1 inhibited VEGFA‐induced VEGFR2 activation, downstream signaling, and VEGF‐induced increases in Bcl‐2, cell number, and the anti‐apoptotic effect of VEGFA in vitro.These results show that the monomeric form of gremlin 1 acts as an antagonist of VEGFR2 activation in the pulmonary microvascular endothelium. Given the previous demonstration that inhibition of VEGFR2 causes marked worsening of HPH, our results suggest that increased gremlin 1 in the hypoxic lung, in addition to blocking BMP receptor type‐2 (BMPR2) signaling, contributes importantly to the development of PH by a non‐canonical VEGFR2 blocking activity.
Platelet-derived TLT-1 is a prognostic indicator in ALI/ARDS and prevents tissue damage in the lungs in a mouse model
Authors: Morales-Ortíz Jessica , Deal Victoria , Reyes Fiorella , Maldonado-Martínez Gerónimo , Ledesma Nahomy , Staback Franklin , Croft Cheyanne , Pacheco Amanda , Ortiz-Zuazaga Humberto , Yost C. Christian , Rowley Jesse W. , Madera Bismark , John Alex St. , Chen Junmei , Lopez Jose , Rondina Matthew T. , Hunter Robert , Gibson Angelia , Washington A. Valance 
Published: October 2018

AbstractAcute lung injury (ALI) and acute respiratory distress syndrome (ARDS) affect &gt;200 000 individuals yearly with a 40% mortality rate. Although platelets are implicated in the progression of ALI/ARDS, their exact role remains undefined. Triggering receptor expressed in myeloid cells (TREM)–like transcript 1 (TLT-1) is found on platelets, binds fibrinogen, and mediates clot formation. We hypothesized that platelets use TLT-1 to manage the progression of ALI/ARDS. Here we retrospectively measure plasma levels of soluble TLT-1 (sTLT-1) from the ARDS Network clinical trial and show that patients whose sTLT-1 levels were &gt;1200 pg/mL had nearly twice the mortality risk as those with &lt;1200 pg/mL (P &lt; .001). After correcting for confounding factors such as creatinine levels, Acute Physiology And Chronic Health Evaluation III scores, age, platelet counts, and ventilation volume, sTLT-1 remains significant, suggesting that sTLT-1 is an independent prognostic factor (P &lt; .0001). These data point to a role for TLT-1 during the progression of ALI/ARDS. We use a murine lipopolysaccharide-induced ALI model and demonstrate increased alveolar bleeding, aberrant neutrophil transmigration and accumulation associated with decreased fibrinogen deposition, and increased pulmonary tissue damage in the absence of TLT-1. The loss of TLT-1 resulted in an increased proportion of platelet-neutrophil conjugates (43.73 ± 24.75% vs 8.92 ± 2.4% in wild-type mice), which correlated with increased neutrophil death. Infusion of sTLT-1 restores normal fibrinogen deposition and reduces pulmonary hemorrhage by 40% (P ≤ .001) and tissue damage by 25% (P ≤ .001) in vivo. Our findings suggest that TLT-1 uses fibrinogen to govern the transition between inflammation and hemostasis and facilitate controlled leukocyte transmigration during the progression of ARDS.
The phase 3 DUO trial: duvelisib vs ofatumumab in relapsed and refractory CLL/SLL
Authors: Flinn Ian W. , Hillmen Peter , Montillo Marco , Nagy Zsolt , Illés Árpád , Etienne Gabriel , Delgado Julio , Kuss Bryone J. , Tam Constantine S. , Gasztonyi Zoltán , Offner Fritz , Lunin Scott , Bosch Francesco , Davids Matthew S. , Lamanna Nicole , Jaeger Ulrich , Ghia Paolo , Cymbalista Florence , Portell Craig A. , Skarbnik Alan P. , Cashen Amanda F. , Weaver David T. , Kelly Virginia M. , Turnbull Barry , Stilgenbauer Stephan 
Published: October 2018

Abstract
Duvelisib (also known as IPI-145) is an oral, dual inhibitor of phosphatidylinositol 3-kinase δ and γ (PI3K-δ,γ) being developed for treatment of hematologic malignancies. PI3K-δ,γ signaling can promote B-cell proliferation and survival in clonal B-cell malignancies, such as chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma (SLL). In a phase 1 study, duvelisib showed clinically meaningful activity and acceptable safety in CLL/SLL patients. We report here the results of DUO, a global phase 3 randomized study of duvelisib vs ofatumumab monotherapy for patients with relapsed or refractory (RR) CLL/SLL. Patients were randomized 1:1 to oral duvelisib 25 mg twice daily (n = 160) or ofatumumab IV (n = 159). The study met the primary study end point by significantly improving progression-free survival per independent review committee assessment compared with ofatumumab for all patients (median, 13.3 months vs 9.9 months; hazard ratio [HR] = 0.52; P &lt; .0001), including those with high-risk chromosome 17p13.1 deletions [del(17p)] and/or TP53 mutations (HR = 0.40; P = .0002). The overall response rate was significantly higher with duvelisib (74% vs 45%; P &lt; .0001) regardless of del(17p) status. The most common adverse events were diarrhea, neutropenia, pyrexia, nausea, anemia, and cough on the duvelisib arm, and neutropenia and infusion reactions on the ofatumumab arm. The DUO trial data support duvelisib as a potentially effective treatment option for patients with RR CLL/SLL. This trial was registered at www.clinicaltrials.gov as #NCT02004522.
tTEM — A towed transient electromagnetic system for detailed 3D imaging of the top 70 m of the subsurface
Authors: Auken Esben , Foged Nikolaj , Larsen Jakob Juul , Lassen Knud Valdemar Trøllund , Maurya Pradip Kumar , Dath Søren Møller , Eiskjær Tore Tolstrup 
Published: October 2018

There is a growing need for detailed investigation of the top 30–50 m of the subsurface, which is critical for infrastructure, water supply, aquifer storage and recovery, farming, waste deposits, and construction. Existing geophysical methods are capable of imaging this zone; however, they have limited efficiency when it comes to creating full 3D images with high resolution over dozens to hundreds of hectares. We have developed a new and highly efficient towed transient electromagnetic (tTEM) system, which is capable of imaging the subsurface up to depth of 70 m at a high resolution, horizontally and vertically. Towed by an all-terrain vehicle, the system uses a [Formula: see text] transmitter coil and has a [Formula: see text]-component receiver placed at 9 m offset from the transmitter. The tTEM uses dual transmitter moment (low and high moment) measurement sequence to obtain the early and late time gates corresponding to shallow and deep information about the subsurface layers. The first bias-free gate is as early as [Formula: see text] from beginning of the ramp ([Formula: see text] after end of ramp). Data are processed and inverted using methods directly adopted from airborne electromagnetics. The system has been successfully used in Denmark for various purposes, e.g., mapping raw materials, investigating contaminated sites, and assessing aquifer vulnerability. We have also used the tTEM system in the Central Valley of California (United States) for locating artificial recharge sites and in the Mississippi Delta region, to map complex subsurface geology in great detail for building hydrogeologic models.