bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reprogrammed Lung Metastasis Immunodeficiency via Targeted Penetrated Delivery of M1 Macrophage‐Wrapped NanoCubes‐Mediated T Cell Infiltration
Authors: Wang Kang‐Li , Li Cheng‐Han , Huang Pin‐Xuan , Liu Hsiu‐Ching , Yalamandala Bhanu Nirosha , Pan Wan‐Chi , Iao Hoi Man , Hu Shang‐Hsiu 
Published: November 2024

AbstractThe infiltration of cytotoxic T lymphocytes holds promise for suppressing even the most resilient metastatic tumors in immunotherapy. Polarizing tumor‐associated macrophages (TAMs) and remodeling the immune‐deficient tumor microenvironment (TME) can enhance T lymphocyte recruitment and infiltration. However, the immune privilege and low immunogenic responses of these aggressive tumor clusters often limit lymphocyte recruitment. Here, an M1 macrophage membrane‐coated iron oxide nanoparticle (IO@MM) double as a tumor‐penetrated agent and naïve M0 macrophage to M1 polarizer is developed for lung metastatic colorectal cancer (CRC) immunotherapy. At the tumor site, IO@MM combined with resiquimod (R848) increased the immune cell infiltration, turning the “Cold” TME into an immune‐activating “Hot” one. Together with self‐cascade immunotherapy, IO@MM with R848 promotes tumor release of damage‐associated molecular patterns (DAMPs). At the same time, IO@MM uses the membrane as an antigen reservoir and provides autologous DAMPs to retain dendritic cells. This IO@MM effectively inhibits tumors and improves survival rate as an immunomodulator in lung metastasis.
Constructing Nitrogen‐Coordinated Single Atom Catalysts via Bond‐Plucking Strategy for Oxidation of Benzene
Authors: Wang Xuejing , Yang Lihua , Li Jian , Yin Zhongqian , Chen Yao , Tian Qing , Yang Yingchun , Liu Huifang , Zhang Lianbing 
Published: November 2024

AbstractSingle‐atom catalysts (SACs) with nitrogen‐coordinated active centers feature unique electronic and geometric structures and thus show high catalytic activity for various industrial reactions. Searching for operable synthesis protocols to accurately devise SACs is vital but remains challenging because commonly used high‐temperature pyrolysis always causes unpredictable structural changes and inhomogeneous single‐atom sites. Herein, a mild bond‐plucking strategy is reported to construct atomically dispersed Cu supported on graphene‐liked C3N4 (g‐C3N4) under lower than 100 °C, and Cu foam is used as the source of metal. When g‐C3N4 closely coats the surface of Cu foam, Cu0 atoms on Cu foam transfer electrons to nitrogen on g‐C3N4 due to the strong Lewis acbase interaction, simultaneously forming Cuδ+ (0 < δ < 2) and Cu─N bonds. Subsequently, g‐C3N4 nanosheets are exfoliated out from the surface of Cu foam, eventually obtaining a well‐defined Cu single atoms/g‐C3N4 (Cu SAs/g‐C3N4) catalyst with atomically dispersed Cu‐N3 moieties. Cu SAs/g‐C3N4 serves as a highly effective and durable catalyst toward the oxidation of benzene to phenol at 60 °C, with a conversion of 65.1% and selectivity of 97.6% after 12 h. The findings pave a new way to construct well‐defined SACs at low costs, promoting large‐scale production and industrial application.
Cellulose Nanocrystal Composite Membrane Enhanced with In Situ Grown Metal–Organic Frameworks for Osmotic Energy Conversion
Authors: Wang Xiuxiu , Li Minmin , Xiong Yuting , Qin Haijuan , Li Qiongya , Zhang Fusheng , Yu Yong‐Liang , Qing Guangyan 
Published: November 2024

AbstractAccess to clean and renewable energy, osmotic energy from salinity gradient difference, for example, is central to the sustainability of human civilization. Despite numerous examples of nanofluidic membranes for osmotic energy conversion, one produced from abundant and renewable biomass resources remains largely unexplored. In this work, cotton‐derived cellulose nanocrystals (CNCs) are employed to fabricate a membrane by self‐assembly with polyvinyl alcohol (PVA) and subsequent in situ growth of metal–organic framework (MOF), UiO‐66‐(COOH)2, to provide an example. The composite membrane exhibits excellent mechanical strength and toughness due to the long chains and hydrogen bonding interactions of PVA. The incorporation of UiO‐66‐(COOH)2 endows the composite membrane with abundant nano‐ and subnano‐sized ion transport channels, resulting in a 150% increase in ion conductance, while also providing superior cation selectivity through collaboration with the sulfated CNCs. The composite membrane with 27.4% MOF content can achieve an osmotic energy conversion performance of 5.10 W m−2 under a 50‐fold KCl gradient condition and a monovalent cation selectivity of ≈16 for K+/Mg2+. This work presents a solution for harvesting renewable osmotic energy by constructing nanofluidic membranes using plentiful renewable biomass materials and a simple, low‐emission fabrication procedure.
Waste‐To‐Energy: Sustainable Triboelectric Stimulating System Constructed by Bone Gelatin Based Triboelectric Nanogenerator for Crop Growth
Authors: Gao Dangge , Wu Haoyuan , Lyu Bin , Zheng Chi , Zhou Yingying , Ma Jianzhong 
Published: November 2024

AbstractThe misuse of synthetic chemicals such as pesticides and fertilizers harms the environment and human health. Abandoning them risks global food shortages. Urgent eco‐friendly alternatives are needed for food production without excessive synthetic chemicals. To respond to this challenge, an innovative approach uses POSS polymer (PA) to modify waste bone gelatin (BG), constructinging a biodegradable triboelectric nanogenerator (PAG‐TENG) tailored for the triboelectric stimulating system for seed germination (PTSS). Amide groups of PA improve the electron supplying capacity of BG and 3D cage structure captures and transfers charges of BG, thereby improving the output performance of PAG‐TENG. The spatial electrostatic field formed by PAG‐TENG promotes seed germination when subjected to pressure changes in the environment. Hence output performance of PAG‐TENG is improved from 52.34 V and 40.25 nA to 247.15 V and 482.12 nA, the sensitivity is 14.4957 V*kPa−1. It maintains initial stable performance after the 6000 cycles of testing. Besides, the prepared PAG‐TENG has good toughness, translucency, and degradability. Treated by the high voltage electrostatic field of PTSS, peas' germination rate remarkably increased by ≈27%. This work realizes the high‐value utilization of waste resource BG, and provides a novel direction for the development of intelligent agriculture.
Self‐Healing and Antifreezing/Antidrying Conductive Eutectohydrogel‐Based Biosignal Monitoring Multisensors with Integrated Supercapacitor
Authors: Lee Jinyoung , Kim Somin , Kim Jung Wook , Kim Jiyoon , Choi Yeonji , Park Mihyeon , Kim Dong Sik , Lee Hanchan , Kim Seojin , Kim Yongju , Ha Jeong Sook 
Published: November 2024

AbstractA novel self‐healing and antifreezing/antidrying conductive eutectohydrogel, ideal for wearable multifunctional sensors and supercapacitors, is reported. Conductive eutectohydrogel with self‐healing and facilely tunable mechanical performance is obtained by incorporation of trehalose and phytic acid as reversible cross‐linkers into a polyacrylamide network, forming the dynamic hydrogen bonding and electrostatic interactions. Furthermore, combined use of deep eutectic solvent with water ensures the air stability as well as the antifreezing/antidrying characteristics. The synthesized eutectohydrogel exhibits a self‐healing efficiency of 90.7% after 24 h at room temperature, Young's modulus of 140.9 kPa, and strain at break of 352.8%. With the eutectohydrogel as a versatile platform, self‐healing strain and temperature sensors, electrocardiogram electrodes, and supercapacitor are fabricated, recovering the device performance after self‐healing from complete bisection and exhibiting stable performance over a wide temperature range from −20 to 50 °C. With a vertically integrated patch device of supercapacitor and strain sensor attached onto skin, various body movements are successfully detected using the energy stored in the supercapacitor, without performance degradation even after self‐healing from complete bisection of the full patch device. This work demonstrates high potential application of the synthesized eutectohydrogel to flexible wearable devices featuring durability and longevity.
Extreme Toughening of Conductive Hydrogels Through Synergistic Effects of Mineralization, Salting‐Out, and Ion Coordination Induced by Multivalent Anions
Authors: Luo Hongmei , Jiang Lichao , Guo Yuxin , Li Min , Hu Longyu , Wu Hao , Cui Wei , Ran Rong 
Published: November 2024

AbstractDeveloping conductive hydrogels with both high strength and fracture toughness for diverse applications remains a significant challenge. In this work, an efficient toughening strategy is presented that exploits the multiple enhancement effects of anions through a synergistic combination of mineralization, salting‐out, and ion coordination. The approach centers on a hydrogel system comprising two polymers and a cation that is highly responsive to anions. Specifically, polyvinyl alcohol (PVA) and chitosan quaternary ammonium (HACC) are used, as PVA benefits from salting‐out effects and HACC undergoes ion coordination with multivalent anions. After just 1 h of immersion in an anionic solution, the hydrogel undergoes a dramatic improvement in mechanical properties, increasing by more than three orders of magnitude. The optimized hydrogel achieves high strength (26 MPa), a high Young's modulus (45 MPa), and remarkable fracture toughness (67.3 kJ m−2), representing enhancements of 860, 3200, and 1200 times, respectively, compared to its initial state. This breakthrough overcomes the typical trade‐off between stiffness and toughness. Additionally, the ionic conductivity of the hydrogel enables reliable strain sensing and supports the development of durable supercapacitors. This work presents a simple and effective pathway for developing hydrogels with exceptional strength, toughness, and conductivity.
Functional carbon‐based materials for structural health monitoring and protection of concrete structures
Authors: Górski Marcin , Safuta Małgorzata 
Published: November 2024

AbstractIn the late 1980s, research began on the functionalization of concrete in the context of self‐monitoring. For this purpose, conductive functional fillers placed in a cement matrix were used. The aim of this article is to present an overview of historical solutions, and the latest trends related to the use of conductive materials, ranging from the detection of structural failures to continuous monitoring of deformations. The article presents a critical review of self‐monitoring methods being developed, including concrete with carbon fibers and nanofibers or conductive carbon nanomaterials (such as carbon nanotubes, graphene‐family materials and nanocarbon black), cementitious, polymeric, and AAM (Alkali Activated Materials) repair materials with crack detection features, FRP‐based smart‐strengthening solutions, and monitoring reinforcement rebars. Measurement methods and their development toward in situ applications are also discussed. The paper highlights the major challenges within the field as well as future development paths for the use of multifunctional concrete composites in civil engineering. In particular, the article indicates directions for further research on biomimetic solutions, including those in the areas of monitoring of other non‐mechanical parameters, using functional materials for electrochemical protection of structures, wireless communication, integration with the BIM environment, energy harvesting, actuation, and others.
Exploring Social Media Use in Cross‐Border E‐Commerce and the Internationalization Process: A Comparative Study of Cross‐Country and Firm Size
Authors: Knösel Cosima Tabea , Cheng Colin C. J. , Shiu Eric C. 
Published: November 2024

ABSTRACTPrior research on social media has considerably advanced our understanding of how social media use affects international market performance. However, extant social media literature has not addressed why social media use stimulates positive results in modern cross‐border e‐commerce and how it evolves in the internationalization process. Overlooking the role of social media use in the above issues has limited our understanding of international business management. Drawing on the Uppsala model, this study used the case study method in the form of a cross‐country comparative study including six large enterprises (LEs) and six small and medium enterprises (SMEs) from Germany, Thailand, and Taiwan, respectively. The results provide compelling evidence that the way of using social media significantly differs in cross‐border e‐commerce among countries, while the main internationalization process differs fundamentally between LEs and SMEs. As such, this study provides novel theoretical insights to scholars and empirical implications to practitioners.
Chronic Exposure of Zebrafish to Iron and Aluminum: Evaluation of Reversal and Generational Transposition of Behavioral, Histopathological, and Genotoxic Changes
Authors: Rodrigues Gabriela Zimmermann Prado , Finkler Mariana , dos Santos Thainá Garbino , Kayser Juliana Machado , Lima Diego Del Duca , Burghausen Jorge Henrique , de Oliveira Diogo Losch , Ziulkoski Ana Luiza , Gehlen Günther 
Published: November 2024

ABSTRACTThis study aimed to report the effects of chronic exposure of zebrafish exposed to environmentally relevant concentrations of 0.5, 2.4, and 5.0 mg L−1 iron (Fe) and 0.2, 0.4, and 2.0 mg L−1 aluminum (Al). We also evaluated the reversal and generational transposition (F1) of possible histopathological, behavioral, and genotoxic changes in the species. Locomotion changes that may have been caused by the increase in the number of apoptotic cells and in the telencephalic mitochondrial activity were observed especially after the 30 days exposure to Al and persisted after recovery (30 days). We also observed histopathological changes, such as an increase in the number of intestinal goblet cells, even after the recovery period in these animals. Our results also showed that the Fe concentrations used were insufficient to cause genotoxicity, behavioral and intestinal epithelium changes. The adult offspring (F1) of animals exposed to Al showed changes in locomotion and in the amount of goblet cells, demonstrating that even in low concentrations this pollutant can harm subsequent generations in the aquatic biota. Animals demonstrate, in general, greater tolerance to Fe which may be related to the physiological demand of this metal by the body. Even so, all concentrations of both metals that caused some change in the species represent Brazilian environmental occurrences or Brazilian legislation. It highlights the need for updating the guidelines and constant monitoring of aquatic environments, since even in the face of a hypothetical decontamination of the environment, some changes could persist and affect different trophic levels.
Soybean genomics research community strategic plan: A vision for 2024–2028
Authors: Stupar Robert M. , Locke Anna M. , Allen Doug K. , Stacey Minviluz G. , Ma Jianxin , Weiss Jackie , Nelson Rex T. , Hudson Matthew E. , Joshi Trupti , Li Zenglu , Song Qijian , Jedlicka Joseph R. , MacIntosh Gustavo C. , Grant David , Parrott Wayne A. , Clemente Tom E. , Stacey Gary , An Yong‐qiang Charles , Aponte‐Rivera Jose , Bhattacharyya Madan K. , Baxter Ivan , Bilyeu Kristin D. , Campbell Jacqueline D. , Cannon Steven B. , Clough Steven J. , Curtin Shaun J. , Diers Brian W. , Dorrance Anne E. , Gillman Jason D. , Graef George L. , Hancock C. Nathan , Hudson Karen A. , Hyten David L. , Kachroo Aardra , Koebernick Jenny , Libault Marc , Lorenz Aaron J. , Mahan Adam L. , Massman Jon M. , McGinn Michaela , Meksem Khalid , Okamuro Jack K. , Pedley Kerry F. , Rainey Katy Martin , Scaboo Andrew M. , Schmutz Jeremy , Song Bao‐Hua , Steinbrenner Adam D. , Stewart‐Brown Benjamin B. , Toth Katalin , Wang Dechun , Weaver Lisa , Zhang Bo , Graham Michelle A. , O'Rourke Jamie A. 
Published: November 2024

AbstractThis strategic plan summarizes the major accomplishments achieved in the last quinquennial by the soybean [Glycine max (L.) Merr.] genetics and genomics research community and outlines key priorities for the next 5 years (2024–2028). This work is the result of deliberations among over 50 soybean researchers during a 2‐day workshop in St Louis, MO, USA, at the end of 2022. The plan is divided into seven traditional areas/disciplines: Breeding, Biotic Interactions, Physiology and Abiotic Stress, Functional Genomics, Biotechnology, Genomic Resources and Datasets, and Computational Resources. One additional section was added, Training the Next Generation of Soybean Researchers, when it was identified as a pressing issue during the workshop. This installment of the soybean genomics strategic plan provides a snapshot of recent progress while looking at future goals that will improve resources and enable innovation among the community of basic and applied soybean researchers. We hope that this work will inform our community and increase support for soybean research.
Do Intravenous Butaphosphan and Cyanocobalamin Combination Affect Insulin Resistance and Metabolic Profile of Dairy Goats During Their Transition Period?
Authors: Zare Asghar , Chalmeh Aliasghar , Pourjafar Mehrdad , Amirian Armin 
Published: November 2024

ABSTRACTBackgroundInsulin resistance during early lactation in goats has been a topic of interest for researchers, as addressing this issue can significantly improve their metabolic health.ObjectivesTo investigate the potential of butaphosphan and cyanocobalamin in controlling insulin resistance, we conducted a study with the hypothesis that this combination may mitigate insulin resistance in dairy goats.MethodsTen adult goats were divided equally into two groups: Ctrl and B+C. The Ctrl group received 6 mL of normal saline, while the second group was administered 6 mL of 10% butaphosphan and 0.005% cyanocobalamin on days 21, 20, 19, and 12, 11, 10, and 3, 2, 1 before parturition. On the 10th and 20th days after parturition, blood samples were gathered to analyze the levels of different metabolites and evaluate insulin resistance/sensitivity through an intravenous glucose tolerance test and surrogate indices. Body condition scores, milk production, and weight gain of the kids were also recorded during the study.ResultsAlthough the B+C group showed slightly higher insulin responsiveness than the Ctrl group in the intravenous glucose tolerance test, but the difference was insignificant. Comparably, no significant differences were noticed in the remaining metabolic indicators amidst the Ctrl and B+C groups.ConclusionsThe lack of substantial differences can be attributed to the limited sample size and the prescribed drug dosage. Further investigations with higher doses exceeding 6 mL are warranted to explore potential effects. Additionally, species‐specific differences in ruminants might exist, and caprine metabolism of the compound might differ from that of bovine and ovine. Consequently, we recommend conducting more studies in this field.
Dietary Supplements Improve the Growth Performance and Carcass Yields of Indigenous Sheep in Ethiopia: A Systematic Review and Meta‐Analysis Study
Authors: Ebrahim Hussen , Alemayehu Kefyalew 
Published: November 2024

ABSTRACTDespite the large number of sheep in Ethiopia, their productivity remains low, mainly due to inadequate and poor‐quality feed. Therefore, this systematic review and meta‐analysis study was conducted to evaluate the effect of dietary supplements on the growth performance and carcass yield indices of indigenous sheep in Ethiopia. This study included a total of 21 studies that used 533 sheep from 11 breeds. We used Meta‐Essentials Version 1.5 to determine the effect sizes in a mixed‐effects model at p < 0.05. The current meta‐analyses revealed that dietary supplements had a positive and significant effect (p of Z ≤ 0.001) on the total dry matter intake (Hedges' g = 6.84 g/day/head), final body weight (Hedges' g = 3.65 kg/head), average daily gain (Hedges' g = 3.59 g/head), feed conversion efficiency (Hedges' g = 0.72 g/g), slaughter weight (Hedges' g = 2.56 kg/head) and hot carcass (Hedges' g = 2.73 kg/head) of sheep compared to the control. The meta‐analysis suggests that sheep of different breeds and sexes that were fed supplemental diets responded differently. In addition, the subgroup analysis declared that dietary supplementation of legumes resulted in a higher magnitude of effect sizes for all response variables in sheep in comparison to sheep supplemented with concentrate and browse. We detected diverse heterogeneity across studies for all response variables that ranged between 0% and 96.65%. It can be concluded that dietary supplements had a positive and significant impact on feed efficiency, growth performance and carcass yield in indigenous sheep, particularly Afar sheep, followed by Arsi Bale and Washera sheep, in Ethiopia.
Prelude: A Fresh Look
Authors: Herbst Gernot , Madonski Rafal 
Published: November 2024

Abstract
Several aspects make this book different, and doing things not the usual way is its recurring motif. Therefore, in this chapter, we focus on establishing those unique aspects of the book that constitute its claimed titular “fresh look.” This expression has a double meaning here. On the one hand, it refers to the active disturbance rejection control (ADRC) as this unorthodox approach in the control landscape and on the other to the fresh look at how ADRC can be introduced to those interested in it. We will also answer here some basic important questions like what exactly is in the book, why is it constructed the way it is, to whom the book is for, and what is the best way to use it depending on the reader’s background.
First Contact with ADRC
Authors: Herbst Gernot , Madonski Rafal 
Published: November 2024

Abstract
We strive to make the initial encounter with ADRC a smooth and pleasant experience for novices. Therefore, in this chapter, we will rely heavily on illustrative examples inspired by real plants. With such a “show, don’t tell” narration, we want to introduce the fundamental aspects of ADRC for some easily recognizable systems from engineering practice. We purposefully avoid complicated jargon and derivations here to give readers the gist of how the ADRC approach can be used to look at and solve various control problems. We deliberately focus on showing ad hoc solutions for first- and second-order plants as they are the most prevalent. Through the shown illuminative examples, we hope that you will not only start seeing a pattern in the design process of the ADRC methodology but also be intrigued enough about its simplicity and effectiveness to want to explore it further with this book.
Linear Active Disturbance Rejection Control
Authors: Herbst Gernot , Madonski Rafal 
Published: November 2024

Abstract
As the core of all other ADRC variants covered in this book, the linear continuous-time state-space form of active disturbance rejection control is introduced in this chapter. Generalizing the first- and second-order cases considered in Chap. 2, the structure of Nth-order linear ADRC is being discussed, consisting of observer and state-feedback controller. Equations for tuning both observer and controller are derived for the so-called bandwidth parameterization approach.