bluuebunny/crossref_metadata_2025_split huggingface dataset:
A new hope for early psychosis care: the evolving landscape of digital care tools
Authors: Torous John , Woodyatt Jessica , Keshavan Matcheri , Tully Laura M. 
Published: February 2019

SummaryImproving understanding of and outcomes for early-course psychosis (ECP) is a recognised global mental health priority. We argue digital health technologies can advance care for ECP by better accounting for clinical heterogeneity, offering better predictive models, increasing access to early interventions and enhancing existing treatment options.Declaration of interestL.M.T. owns shares in Safari Health Inc – a digital health technology company.
High Titers of Thyrotropin Receptor Antibodies Are Associated With Orbitopathy in Patients With Graves Disease
Authors: Kahaly George J , Wüster Christian , Olivo Paul D , Diana Tanja 
Published: February 2019

AbstractContextSerum TSH receptor autoantibody (TSH-R-Ab) is a biomarker of Graves disease (GD). Studies have shown that the levels of this TSH-R-Ab have clinical significance.ObjectiveTo differentiate between thyroidal GD only and Graves orbitopathy (GD + GO).DesignControlled, follow-up study.SettingAcademic tertiary referral center for GD + GO.SubjectsSixty patients with GD, GD + GO, and controls.InterventionSerial serum dilution analyses with six automated, ELISA, and cell-based assays for TSH-R-Ab.Main Outcome MeasureDifferentiation among GD phenotypes.ResultsAll undiluted samples of hyperthyroid-untreated GD patients were positive with the six assays but became negative at dilution 1:9 in four of six assays. In contrast, all undiluted samples of hyperthyroid-untreated GD + GO patients remained positive up to dilution 1:81, P &lt; 0.001. At high dilutions 1:243, 1:729, 1:2187, and 1:6561, the rate of stimulating TSH-R-Ab positivity in the bioassay for GD + GO patients was 75%, 35%, 5%, and 0%, respectively (all P &lt; 0.001). The five ELISA and/or automated assays confirmed this marked difference of anti-TSH-R-Ab detection between GD-only and GD + GO. In comparison, the baseline-undiluted samples of GD vs GD + GO showed an overlap in the ranges of TSH-R-Ab levels. Subsequent to 12-month methimazole treatment, samples from euthyroid GD + GO patients were still TSH-R-Ab positive at the high dilution of 1:243. In contrast, all GD samples were negative already at dilution 1:3. A GD patient with TSH-R-Ab positivity at dilution 1:729 developed de novo GO.ConclusionsTSH-R-Ab titers, as determined by dilution analysis, significantly differentiate between GD and GD + GO.
Subversive Sisterhood
Authors: Saylor Elizabeth Claire 
Published: February 2019

AbstractThis article examines the Arabic fiction of ʿAfifa Karam (1883–1924), an overlooked contributor to the nahda, or the Arabic cultural renaissance of the mid- to late nineteenth and early twentieth centuries. Born in Mount Lebanon, Karam became a novelist, journalist, and translator in the North American mahjar (Arab diaspora). A discussion of Karam’s novel, Fatima al-Badawiyya (Fatima the Bedouin), published in New York City in 1909, explores the author’s engagement with gender politics within a hybridized cultural space. Such attention also reveals the transnational character of nahda literary culture, as readers and writers scattered across four continents interacted in the textual “spaces” of the rapidly expanding print culture in the Arabic-speaking world. As a single player within an international network of Syro-Lebanese women writers, Karam’s foundational feminist fiction reveals her cosmopolitan female subjectivity, offering a radical vision of global sisterhood that transcends geographic, political, and religious boundaries.
Activated MLKL attenuates autophagy following its translocation to intracellular membranes
Authors: Frank Daniel , Vaux David L. , Murphy James M. , Vince James E. , Lindqvist Lisa M. 
Published: February 2019

ABSTRACT
Necroptosis is an inflammatory form of programmed cell death mediated by the pseudokinase mixed-lineage kinase domain-like protein (MLKL). Upon phosphorylation by receptor-interacting protein kinase-3 (RIPK3), MLKL oligomerizes, and translocates to and disrupts the plasma membrane, thereby causing necroptotic cell lysis. Herein, we show that activation of necroptosis in mouse dermal fibroblasts (MDFs) and HT-29 human colorectal cancer cells results in accumulation of the autophagic marker, lipidated LC3B (also known as MAP1LC3B), in an MLKL-dependent manner. Unexpectedly, the necroptosis-induced increase in lipidated LC3B was due to inhibition of autophagic flux, not the activation of autophagy. Inhibition of autophagy by MLKL correlated with a decrease in autophagosome and/or autolysosome function, and required the association of activated MLKL with intracellular membranes. Collectively, our findings uncover an additional role for the MLKL pseudokinase, namely to inhibit autophagy during necroptosis.
An alternative membrane topology permits lipid droplet localization of peroxisomal fatty acyl-CoA reductase 1
Authors: Exner Tarik , Romero-Brey Inés , Yifrach Eden , Rivera-Monroy Jhon , Schrul Bianca , Zouboulis Christos C. , Stremmel Wolfgang , Honsho Masanori , Bartenschlager Ralf , Zalckvar Einat , Poppelreuther Margarete , Füllekrug Joachim 
Published: February 2019

ABSTRACT
Fatty acyl-CoA reductase 1 (Far1) is a ubiquitously expressed peroxisomal membrane protein that generates the fatty alcohols required for the biosynthesis of ether lipids. Lipid droplet localization of exogenously expressed and endogenous human Far1 was observed by fluorescence microscopy under conditions of increased triglyceride synthesis in tissue culture cells. This unexpected finding was supported further by correlative light electron microscopy and subcellular fractionation. Selective permeabilization, protease sensitivity and N-glycosylation tagging suggested that Far1 is able to assume two different membrane topologies, differing in the orientation of the short hydrophilic C-terminus towards the lumen or the cytosol, respectively. Two closely spaced hydrophobic domains are contained within the C-terminal region. When analyzed separately, the second domain was sufficient for the localization of a fluorescent reporter to lipid droplets. Targeting of Far1 to lipid droplets was not impaired in either Pex19 or ASNA1 (also known as TRC40) CRISPR/Cas9 knockout cells. In conclusion, our data suggest that Far1 is a novel member of the rather exclusive group of dual topology membrane proteins. At the same time, Far1 shows lipid metabolism-dependent differential subcellular localizations to peroxisomes and lipid droplets.
Phosphorylation of the Bruchpilot N-terminus in Drosophila unlocks axonal transport of active zone building blocks
Authors: Driller Jan H. , Lützkendorf Janine , Depner Harald , Siebert Matthias , Kuropka Benno , Weise Christoph , Piao Chengji , Petzoldt Astrid G. , Lehmann Martin , Stelzl Ulrich , Zahedi René , Sickmann Albert , Freund Christian , Sigrist Stephan J. , Wahl Markus C. 
Published: February 2019

ABSTRACT
Protein scaffolds at presynaptic active zone membranes control information transfer at synapses. For scaffold biogenesis and maintenance, scaffold components must be safely transported along axons. A spectrum of kinases has been suggested to control transport of scaffold components, but direct kinase–substrate relationships and operational principles steering phosphorylation-dependent active zone protein transport are presently unknown. Here, we show that extensive phosphorylation of a 150-residue unstructured region at the N-terminus of the highly elongated Bruchpilot (BRP) active zone protein is crucial for ordered active zone precursor transport in Drosophila. Point mutations that block SRPK79D kinase-mediated phosphorylation of the BRP N-terminus interfered with axonal transport, leading to BRP-positive axonal aggregates that also contain additional active zone scaffold proteins. Axonal aggregates formed only in the presence of non-phosphorylatable BRP isoforms containing the SRPK79D-targeted N-terminal stretch. We assume that specific active zone proteins are pre-assembled in transport packages and are thus co-transported as functional scaffold building blocks. Our results suggest that transient post-translational modification of a discrete unstructured domain of the master scaffold component BRP blocks oligomerization of these building blocks during their long-range transport.
Protein misfolding and aggregation in neurodegenerative diseases: a review of pathogeneses, novel detection strategies, and potential therapeutics
Authors: Gandhi Jason , Antonelli Anthony C. , Afridi Adil , Vatsia Sohrab , Joshi Gunjan , Romanov Victor , Murray Ian V.J. , Khan Sardar Ali 
Published: February 2019

AbstractProtein folding is a complex, multisystem process characterized by heavy molecular and cellular footprints. Chaperone machinery enables proper protein folding and stable conformation. Other pathways concomitant with the protein folding process include transcription, translation, post-translational modifications, degradation through the ubiquitin-proteasome system, and autophagy. As such, the folding process can go awry in several different ways. The pathogenic basis behind most neurodegenerative diseases is that the disruption of protein homeostasis (i.e. proteostasis) at any level will eventually lead to protein misfolding. Misfolded proteins often aggregate and accumulate to trigger neurotoxicity through cellular stress pathways and consequently cause neurodegenerative diseases. The manifestation of a disease is usually dependent on the specific brain region that the neurotoxicity affects. Neurodegenerative diseases are age-associated, and their incidence is expected to rise as humans continue to live longer and pursue a greater life expectancy. We presently review the sequelae of protein misfolding and aggregation, as well as the role of these phenomena in several neurodegenerative diseases including Alzheimer’s disease, Huntington’s disease, amyotrophic lateral sclerosis, Parkinson’s disease, transmissible spongiform encephalopathies, and spinocerebellar ataxia. Strategies for treatment and therapy are also conferred with respect to impairing, inhibiting, or reversing protein misfolding.
Larger Auditory Cortical Area and Broader Frequency Tuning Underlie Absolute Pitch
Authors: McKetton Larissa , DeSimone Kevin , Schneider Keith A. 
Published: February 2019

Absolute pitch (AP), the ability of some musicians to precisely identify and name musical tones in isolation, is associated with a number of gross morphological changes in the brain, but the fundamental neural mechanisms underlying this ability have not been clear. We presented a series of logarithmic frequency sweeps to age- and sex-matched groups of musicians with or without AP and controls without musical training. We used fMRI and population receptive field (pRF) modeling to measure the responses in the auditory cortex in 61 human subjects. The tuning response of each fMRI voxel was characterized as Gaussian, with independent center frequency and bandwidth parameters. We identified three distinct tonotopic maps, corresponding to primary (A1), rostral (R), and rostral-temporal (RT) regions of auditory cortex. We initially hypothesized that AP abilities might manifest in sharper tuning in the auditory cortex. However, we observed that AP subjects had larger cortical area, with the increased area primarily devoted to broader frequency tuning. We observed anatomically that A1, R and RT were significantly larger in AP musicians than in non-AP musicians or control subjects, which did not differ significantly from each other. The increased cortical area in AP in areas A1 and R were primarily low frequency and broadly tuned, whereas the distribution of responses in area RT did not differ significantly. We conclude that AP abilities are associated with increased early auditory cortical area devoted to broad-frequency tuning and likely exploit increased ensemble encoding.SIGNIFICANCE STATEMENTAbsolute pitch (AP), the ability of some musicians to precisely identify and name musical tones in isolation, is associated with a number of gross morphological changes in the brain, but the fundamental neural mechanisms have not been clear. Our study shows that AP musicians have significantly larger volume in early auditory cortex than non-AP musicians and non-musician controls and that this increased volume is primarily devoted to broad-frequency tuning. We conclude that AP musicians are likely able to exploit increased ensemble representations to encode and identify frequency.
Vedic nouns of the rétas- ‘stream; semen’ type and several related problems of Indo-European morphology
Authors: Vijūnas Aurelijus 
Published: February 2019

National Kaohsiung Normal UniversityThe present article is dedicated to the historical analysis of the formant -t- appearing in the Sanskrit neuter s-stem nouns srótas- ‘stream’, rétas- ‘stream; (male) semen’, and †vétas- ‘reed; stick’, as well as the structure and derivation of these nouns. Already Hermann Hirt already proposed that the formant -t- in these nouns was related to the Indo-European t-stems, but alternative interpretations have been put forward as well. Among the existing theories regarding the origin of the formant -t- in these s-stems, Hirt’s theory appears to be the most plausible. A different interpretation regarding the structure and development of their root is proposed in this article, however. Hirt claimed that the normal grade of the root in these nouns was inherited from Indo-European, but an analysis of data suggests that late Indo-European t-stems built to roots of this structure must have had zero grade. The attested full grade must have been introduced only when the reformed roots *srut-, *rit- and *wit- (← **R-t-) were secondarily re-used to build new s-stem nouns.
Andrzej Rudomina—unforgettable Lithuanian Jesuit missionary scholar: from Vilnius University to China
Authors: Konior Jan 
Published: February 2019

Jesuit University of Philosophy and Education ‘Ignatianum’ This paper explores one of great Lithuanian Jesuit missionaries to China—Andrzej Rudomina (Lith. Andrius Rudamina, Chin. Lu an de) 盧安德 (1595–1631)—also providing a look at the cultural and spiritual background of Lithuania and Poland in which he was brought up. It also shows the situation of the Society of Jesus in the 16th and 17th centuries, with particular focus on the Lithuanian–Polish–Chinese context and connection. Andrzej Rudomina was the first Lithuanian Jesuit to set foot behind the Great Wall of China in the 17th century. In 1625 he reached Goa, and then Macau, before studying Chinese literature in Nankeen Province. There he began to immerse himself in the complexities of Chinese customs. The natives called him Lu an de (the Chinese name of Andrzej Rudomina). He reports participating in the Kating Conference (1627), at which was sought the Chinese equivalent for the name of the Lord our God, Tian Zhu 天主. He was very much valued by his Jesuit brothers and by the Chinese. He died prematurely at the age of 35 of tuberculosis. This article will explore the life of Rudomina. We will try to understand this man of holiness, mobility and disponibility. He was a man on mission, but what was nature of the mission and who was it for? What does he have to tell us today in the 21st century? What kind of sign is he for us today?
Bronisław Piłsudski’s heritage and Lithuania
Authors: Majewicz Alfred F. 
Published: February 2019

Adam Mickiewicz University The paper aims at introducing the results of research on the cultures and languages of the aboriginal peoples of the island of Sakhalin, the Lower Amur Region (Priamurye), and northern Japan (Ainu, Nivhgu, Uilta, Ulcha, and Nanai) conducted at the turn of the 19th and 20th century by Polish political exile Bronisław (Ginet) Piłsudski (1866–1918) and at presenting his ties with Lithuania: he used to introduce himself as Samogitian and Lithuanian (besides Polish―here the so-called nested ethnic identity is involved) and especially towards the end of his life emphasised this identity by inserting the name of his Lithuanian ancestors before his Polish family name. His seemingly long-forgotten legacy is now brought back to the attention of specialists with the appearance of the consecutive volumes of his Collected Works. The argumentation and conclusion of this Vilnius University anniversary article is that Piłsudski belongs to the same degree to the history of Oriental studies in both Lithuania and Poland and that both countries involved can only be proud of such a figure in the annals of their intellectual heritage.
The authority of the Buddha: The limits of knowledge in medieval Indian Buddhist epistemology
Authors: Payne Richard 
Published: February 2019

Institute of Buddhist Studies at the Graduate Theological UnionThe Indian religious traditions, including Buddhism, are generally characterised by an understanding of the problematic character of the human condition as ignorance (avidya) instead of sin, as in Christianity.1 The centrality of ignorance in defining the problematic character of the human condition creates a dramatically different religious dynamic—a religious dynamic that is fundamentally concerned with epistemological issues rather than with moral ones. In Indian discussions of the limits of religious knowledge, the shared intellectual framework was the idea of means of valid knowledge (pramāṇa). While other religio-philosophic traditions in India accepted testimony (śabda) as an autonomous (i.e., irreducible) means of valid knowledge, Buddhist epistemologists rejected it. Having rejected the idea that testimony is an autonomous means of valid knowledge (śabdapramāṇa), an alternative explanation for the authority of the Buddha had to be created. Against this background of epistemological discussion, particular attention is given here to Dharmakīrti’s views on the authority of the Buddha as a means of valid knowledge regarding the ground of human existence, the path of religious practice, and the goal of awakening.
Japan as fashion: Contemporary reflections on being fashionable
Authors: Onohara Noriko 
Published: February 2019

University of HyogoThis paper examines how Japanese contemporary fashion has been accepted globally, especially in the case of London. The popularity of Japanese fashion in the West started in the 19th century with kimono-style dressing gowns, but for the true design influence known as Japan-shock, we had to wait for the appearance of the avantgarde Japanese fashion designers who participated in the Paris collection in the 1970s and 1980s. A new keyword for ‘fashionable Japan’ today is kawaii, the notion of cute. This is intimately linked to street fashion and subculture and has been established and received as part of ‘cool Japan’ through the worldwide popularity of Japanese manga and anime. Moreover, it could be said that Japan is fashionable and the Japanese are thought of as fashionable people, but who is described as fashionable, and by whom? To reflect upon this statement, ‘the Japanese are fashionable’, as ideology, picking up the globally popular Japanese street fashion magazine FRUiTS, I would like to investigate the double meaning of fashion in the present and also what it means to be fashionable.
The haunted culture—Shamanic heroes in the cultural content industry of South Korea
Authors: Seo Jinseok 
Published: February 2019

Vytautas Magnus UniversityKorea, with insufficient natural resources and a limited consumer market, began to take notice of the cultural content industry in the 21st century. This means that the cultivation of this industry has not taken place for a long time compared to Japan, the USA or Hong Kong. Yet Korea has obtained an astonishing outcome in a short time. The popular culture of South Korea, with the appellation of hallyu, boasted of an enormous strength initially in the Asian market and subsequently stretched to markets in other countries, too. Seeing that Korean cultural archetypes do not play a successful role in the cultural content business of Korea in general, the position of shamanism is truly trivial among the others. I would like to analyse and discuss the meaning, function and potential of Korean shamanism in the field of the Korean cultural content industry.
Comparative embryonic development of nematodes of the genus Тrichuris (Nematoda, Trichuridae) obtained from sheep (Ovis aries)
Authors: Melnychuk V. V. , Berezovsky А. V. 
Published: February 2019

Biological specifics of Trichuris оvis Abildgaard, 1795 and T. globulosa Linstow, 1901 parasitizing domestic sheep were analyzed enhancing the species identification of these nematode species. The embryonic development of nematodes was timed, survival of embryonic stages was determined taking into account their morphological and metric specifics in laboratory culture. Trichuris eggs were isolated from gonads of adult female nematodes collected from caeca of dissected sheep. Then the eggs were cultured at optimal temperature to the formation of eggs with mobile larvae. Six morphologically distinct stages of embryogenesis were established in T. оvis and T. globulosa nematodes. The protoplast stage lasted from the 1st to the 12th day in T. оvis and to the 18th day in T. globulosa. Blastomeric formation occurred from the 3rd to the 18th day in T. оvis and from the 3rd to the 21st day in T. globulosa. Bean-shaped embryos formed from the 6th to the 21st day in T. оvis, and from the 9th to the 30th day in T. globulosa. Tadpole-like embryos developed from the 12th to the 24th day in T. оvis and from the 18th to the 33rd day in T. globulosa. Larvae formed in eggs of T. оvis from the 18th to the 27th day, and in eggs of T. globulosa from the 21st to the 36th day. Mobile larvae formed from the 21st to the 30th day in T. оvis, and from the 30th to the 39th day in T. globulosa. At 27 °С, mature eggs with mobile larvae developed in 30 days in T. оvis and in 39 in T. globulosa. The egg survival in laboratory culture was 84.3 ± 4.2 % and 76.3 ± 1.5%, respectively. Developmental changes of metric parameters in Trichuris nematode eggs (length and width of eggs, plug length, eggshell thickness) were species-specific.