bluuebunny/crossref_metadata_2025_split huggingface dataset:
Multifunctional transcriptional coactivator PC4 is a global co-regulator of p53-dependent stress response and gene regulation
Authors: Mondal Priya , Saleem Suraiya , Sikder Sweta , Kundu Tapas K , Biswas Subhas Chandra , Roy Siddhartha 
Published: June 2019

AbstractHuman positive coactivator 4 (PC4), a multifunctional chromatin-associated protein, is known to directly interact with p53 and modulate expressions of a few p53-dependent genes. However, the role of PC4 in p53's myriad of other regulatory functions is not known. The p53–PC4 interaction was selectively perturbed by a small peptide which led to abrogation of genotoxic stress-induced up-regulation of many p53-dependent genes and reduction of apoptosis in A549 cells. Over-expression of a PC4 point mutant, incapable of binding p53, recapitulated many of the effects of the peptide. Global gene expression profiling in A549 cells, upon peptide treatment, revealed PC4's involvement in the regulation of many p53-dependent pathways, including the Hippo pathway. Introduction of the peptide in neuronal cells significantly reduced its amyloid-β-induced death. Thus, PC4 emerges as a global co-regulator of p53 and a therapeutic target against pathogeneses where the p53-dependent cell death process plays a crucial role.
Effects of Trap Color and Shape on the Capture of Eucryptorrhynchus scrobiculatus (Coleoptera: Curculionidae)
Authors: Wang Xu , Ji Ying-Chao , Wen Chao , Zhang Gan-Yu , Wen Jun-Bao 
Published: June 2019

Abstract
Eucryptorrhynchus scrobiculatus (Coleoptera:Curculionidae) is an important pest in China that specifically damages Ailanthus altissima (Mill.) Swingle (Sapindales: Simaroubaceae). Trembler grid lamps and food attractant traps frequently were used to monitor and control E. scrobiculatus; however, the effect of these methods is poor in actual application. The purpose of this study was to develop a new monitoring method. Traps of seven colors and two shapes were compared with respect to the attraction of E. scrobiculatus adults, and a field trapping test was performed. We found that E. scrobiculatus adults were most sensitive to red (16.11 ± 7.72) and black traps (14.44 ± 8.07) and to tall vertical black shapes in the laboratory. In the field, red (70.50 ± 5.74) and black traps (60.75 ± 8.22) were most effective at catching E. scrobiculatus, and traps with color and attractant still were more attractive to E. scrobiculatus than traps with colors only. These results provide a reference for monitoring E. scrobiculatus adults.
Efficacy and safety of pemetrexed plus cisplatin as first-line chemotherapy in advanced malignant peritoneal mesothelioma
Authors: Nagata Yusuke , Sawada Ryoichi , Takashima Atsuo , Shoji Hirokazu , Honma Yoshitaka , Iwasa Satoru , Amano Katsushi , Kato Ken , Hamaguchi Tetsuya , Shimada Yasuhiro , Saruta Masayuki , Boku Narikazu 
Published: June 2019

Abstract

Background
Malignant peritoneal mesothelioma (MPeM) is a rare cancer for which no standard systemic chemotherapy has been established. While cisplatin plus pemetrexed, the standard treatment for malignant pleural mesothelioma (MPlM), is usually used for MPeM, its efficacy remains unclear.

Methods
We retrospectively reviewed the medical charts of MPeM patients who had received cisplatin plus pemetrexed as first-line chemotherapy between January 2001 and July 2016 at the National Cancer Center Hospital. Patients received cisplatin 75 mg/m2 and pemetrexed 500 mg/m2 on day1, repeated every 3 weeks until progressive disease, unacceptable toxicities or patient’s refusal to continue.

Results
A total of 29 MPeM patients received cisplatin plus pemetrexed. Median progression-free survival and overall survival were 7.1 months (95% CI: 4.8–9.3) and 15.4 months (95% CI: 9.5–21.2), respectively. Among 16 patients with measurable lesions, the response rate was 38%. Incidences of grade 3/4 leukopenia, neutropenia, anemia and thrombocytopenia were 21%, 17%, 14% and 3%, respectively. Non-hematological toxicities were mild, and there were no treatment-related deaths.

Conclusions
Cisplatin plus pemetrexed, showing consistent efficacy with MPlM, can be recommended as first-line treatment for unresectable MPeM patients.
Reduction of Reproductive Capacity in Aedes albopictus (Diptera: Culicidae) in Hot, Dry Summer
Authors: Alam Md Shah , Tuno Nobuko 
Published: June 2019

AbstractThe summer of 2018 was very hot and dry with little rain nationwide in Japan. Particularly in July, temperature was 3°C higher in comparison with the normal year. We collected adults, pupae, third or fourth instar larvae of Aedes albopictus (Skuse) in Sendai city, Niigata city, and Kanazawa city in late July and early August 2018. Wild-collected adults were examined for reproductive capacity. On the other hand, wild-collected larvae and pupae were raised to adults in the laboratory and then examined for reproductive capacity. They did not lay eggs after single blood feeding. When they were supplied with bloodmeals twice or three times, they laid a small number of eggs, but these eggs did not hatch. When these adult individuals were maintained at 25°C for 3 wk and then fed with blood, they laid healthy eggs which developed to embryos. It is thought that extreme heat and/or extreme low humidity due to low precipitation reduced female reproductive capacity even if they could take bloodmeals.
Elucidating Under-Studied Aspects of the Link Between Obesity and Multiple Myeloma: Weight Pattern, Body Shape Trajectory, and Body Fat Distribution
Authors: Marinac Catherine R , Suppan Catherine A , Giovannucci Edward , Song Mingyang , Kværner Ane S , Townsend Mary K , Rosner Bernard A , Rebbeck Timothy R , Colditz Graham A , Birmann Brenda M 
Published: June 2019

Abstract

Background
Although obesity is an established modifiable risk factor for multiple myeloma (MM), several nuanced aspects of its relation to MM remain unelucidated, limiting public health and prevention messages.

Methods
We analyzed prospective data from the Nurses’ Health Study and Health Professionals Follow-Up Study to examine MM risk associated with 20-year weight patterns in adulthood, body shape trajectory from ages 5 to 60 years, and body fat distribution. For each aforementioned risk factor, we report hazard ratios (HRs) and 95% confidence intervals (CIs) for incident MM from multivariable Cox proportional-hazards models.

Results
We documented 582 incident MM cases during 4 280 712 person-years of follow-up. Persons who exhibited extreme weight cycling, for example, those with net weight gain and one or more episodes of intentional loss of at least 20 pounds or whose cumulative intentional weight loss exceeded net weight loss with at least one episode of intentional loss of 20 pounds or more had an increased MM risk compared with individuals who maintained their weight (HR = 1.71, 95% CI = 1.05 to 2.80); the association was statistically nonsignificant after adjustment for body mass index. We identified four body shape trajectories: lean-stable, lean-increase, medium-stable, and medium-increase. MM risk was higher in the medium-increase group than in the lean-stable group (HR = 1.62, 95% CI = 1.22 to 2.14). Additionally, MM risk increased with increasing hip circumference (HR per 1-inch increase: 1.03, 95% CI = 1.01 to 1.06) but was not associated with other body fat distribution measures.

Conclusions
Maintaining a lean and stable weight throughout life may provide the strongest benefit in terms of MM prevention.
Heat stress effects on source–sink relationships and metabolome dynamics in wheat
Authors: Abdelrahman Mostafa , Burritt David J , Gupta Aarti , Tsujimoto Hisashi , Tran Lam-Son Phan 
Published: June 2019

Abstract
Crops such as wheat (Triticum spp.) are predicted to face more frequent exposures to heat stress as a result of climate change. Increasing the yield and sustainability of yield under such stressful conditions has long been a major target of wheat breeding, and this goal is becoming increasingly urgent as the global population increases. Exposure of wheat plants in their reproductive or grain-filling stage to high temperature affects the duration and rate of grain filling, and hence has a negative impact on wheat productivity. Therefore, understanding the plasticity of the response to heat stress that exists between wheat genotypes, especially in source–sink relationships at the reproductive and grain-filling stages, is critical for the selection of germplasm that can maintain high yields under heat stress. A broad understanding of metabolic dynamics and the relationships between metabolism and heat tolerance is required in order to achieve this goal. Here, we review the current literature concerning the effects of heat stress on sink–source relationships in a wide range of wheat genotypes, and highlight the current metabolomic approaches that are used to investigate high temperature responses in wheat.
bZIP edgetic mutations: at the frontier of plant metabolism, development and stress trade-off
Authors: Lorenzo Oscar 
Published: June 2019

This article comments on:
Garg A, Kirchler T, Fillinger S, Wanke F, Stadelhofer B, Stahl M, Chaban C. 2019. Targeted manipulation of bZIP53 DNA-binding properties influences Arabidopsis metabolism and growth. Journal of Experimental Botany 70, 5659–5671.
A Case of Chronic Thrombocytopenia in a 17-Year-Old Female
Authors: Riley Roger , Khan Asad , Pai Shella , Warmke Laura , Winkler Marcus , Gunning William 
Published: June 2019

AbstractStorage pool deficiency (SPD) is a group of rare platelet disorders that result from deficiencies in α-granules, δ-granules, or both. One type of α-SPD is gray platelet syndrome (GPS), caused by mutations in the neurobeachin-like 2 (NBEAL2) gene that results in a bleeding diathesis, thrombocytopenia, splenomegaly, and progressive myelofibrosis. Due to the lack of α-granules, platelets have a gray and degranulated appearance by light microscopy. However, definitive diagnosis of GPS requires confirmation of α-granule deficiency by electron microscopy. Treatment is nonspecific, with the conservative utilization of platelet transfusions being the most important form of therapy. We present a case of a 17-year-old female with a past medical history of thrombocytopenia, first identified at the age of five. Her clinical symptomatology included chronic fatigue, gingival bleeding, bruising, menorrhagia, and leg pain. This report will discuss both the clinical and the pathophysiologic aspects of this rare platelet disorder.
Characterizing dynamical stages of open clusters located in the Sagittarius spiral arm
Authors: Angelo M S , Piatti A E , Dias W S , Maia F F S 
Published: June 2019

Abstract
The study of dynamical properties of Galactic open clusters (OCs) is a fundamental prerequisite for the comprehension of their dissolution processes. In this work, we characterized 12 OCs, namely: Collinder 258, NGC 6756, Czernik 37, NGC 5381, Ruprecht 111, Ruprecht 102, NGC 6249, Basel 5, Ruprecht 97, Trumpler 25, ESO 129−SC32, and BH 150, projected against dense stellar fields. In order to do that, we employed Washington CT1 photometry and Gaia DR2 astrometry, combined with a decontamination algorithm applied to the three-dimensional astrometric space of proper motions and parallaxes. From the derived membership likelihoods, we built decontaminated colour–magnitude diagrams, while structural parameters were obtained from King profiles fitting. Our analysis revealed that they are relatively young OCs (log(t  yr−1) ∼7.3–8.6), placed along the Sagittarius spiral arm, and at different internal dynamical stages. We found that the half-light radius to Jacobi radius ratio, the concentration parameter and the age to relaxation time ratio describe satisfactorily their different stages of dynamical evolution. Those relative more dynamically evolved OCs have apparently experienced more important low-mass star loss.
Modelling baryonic physics in future weak lensing surveys
Authors: Huang Hung-Jin , Eifler Tim , Mandelbaum Rachel , Dodelson Scott 
Published: June 2019

Abstract
Modifications of the matter power spectrum due to baryonic physics are one of the major theoretical uncertainties in cosmological weak lensing measurements. Developing robust mitigation schemes for this source of systematic uncertainty increases the robustness of cosmological constraints, and may increase their precision if they enable the use of information from smaller scales. Here we explore the performance of two mitigation schemes for baryonic effects in weak lensing cosmic shear: the principal component analysis (PCA) method and the halo-model approach in hmcode. We construct mock tomographic shear power spectra from four hydrodynamical simulations, and run simulated likelihood analyses with cosmolike assuming LSST-like survey statistics. With an angular scale cut of ℓmax &lt; 2000, both methods successfully remove the biases in cosmological parameters due to the various baryonic physics scenarios, with the PCA method causing less degradation in the parameter constraints than hmcode. For a more aggressive ℓmax = 5000, the PCA method performs well for all but one baryonic physics scenario, requiring additional training simulations to account for the extreme baryonic physics scenario of Illustris; hmcode exhibits tensions in the 2D posterior distributions of cosmological parameters due to lack of freedom in describing the power spectrum for $k \gt 10\ h^{-1}\, \mathrm{Mpc}$. We investigate variants of the PCA method and improve the bias mitigation through PCA by accounting for the noise properties in the data via Cholesky decomposition of the covariance matrix. Our improved PCA method allows us to retain more statistical constraining power while effectively mitigating baryonic uncertainties even for a broad range of baryonic physics scenarios.
Simulating the effect of photoheating feedback during reionization
Authors: Wu Xiaohan , Kannan Rahul , Marinacci Federico , Vogelsberger Mark , Hernquist Lars 
Published: June 2019

Abstract
We present self-consistent radiation hydrodynamic simulations of hydrogen reionization performed with arepo-rt complemented by a state-of-the-art galaxy formation model. We examine how photoheating feedback, due to reionization, shapes the galaxies properties. Our fiducial model completes reionization by z ≈ 6 and matches observations of the Ly α forest, the cosmic microwave background electron scattering optical depth, the high-redshift ultraviolet (UV) luminosity function, and stellar mass function. Contrary to previous works, photoheating suppresses star formation rates by more than $50{{\ \rm per\ cent}}$ only in haloes less massive than ∼108.4 M⊙ (∼108.8 M⊙) at z = 6 (z = 5), suggesting inefficient photoheating feedback from photons within galaxies. The use of a uniform UV background that heats up the gas at z ≈ 10.7 generates an earlier onset of suppression of star formation compared to our fiducial model. This discrepancy can be mitigated by adopting a UV background model with a more realistic reionization history. In the absence of stellar feedback, photoheating alone is only able to quench haloes less massive than ∼109 M⊙ at z ≳ 5, implying that photoheating feedback is sub-dominant in regulating star formation. In addition, stellar feedback, implemented as a non-local galactic wind scheme in the simulations, weakens the strength of photoheating feedback by reducing the amount of stellar sources. Most importantly, photoheating does not leave observable imprints in the UV luminosity function, stellar mass function, or the cosmic star formation rate density. The feasibility of using these observables to detect imprints of reionization therefore requires further investigation.
An X-ray reverberation mass measurement of Cygnus X-1
Authors: Mastroserio Guglielmo , Ingram Adam , van der Klis Michiel 
Published: June 2019

ABSTRACT
We present the first X-ray reverberation mass measurement of a stellar-mass black hole. Accreting stellar-mass and supermassive black holes display characteristic spectral features resulting from reprocessing of hard X-rays by the accretion disc, such as an Fe Kα line and a Compton hump. This emission probes the innermost region of the accretion disc through general relativistic distortions to the line profile. However, these spectral distortions are insensitive to black hole mass, since they depend on disc geometry in units of gravitational radii. Measuring the reverberation lag resulting from the difference in path-length between direct and reflected emission calibrates the absolute length of the gravitational radius. We use a relativistic model able to reproduce the behaviour of the lags as a function of energy for a wide range of variability time-scales, addressing both the reverberation lags on short time-scales and the intrinsic hard lags on longer time-scales. We jointly fit the time-averaged spectrum and the real and imaginary parts of the cross-spectrum as a function of energy for a range of Fourier frequencies to Rossi X-ray Timing Exporer data from the X-ray binary Cygnus X-1. We also show that introducing a self-consistently calculated radial ionisation profile in the disc improves the fit, but requires us to impose an upper limit on ionization profile peak to allow a plausible value of the accretion disc density. This limit leads to a mass value more consistent with the existing dynamical measurement.
Horizontal Transfer of Bacterial Cytolethal Distending Toxin B Genes to Insects
Authors: Verster Kirsten I , Wisecaver Jennifer H , Karageorgi Marianthi , Duncan Rebecca P , Gloss Andrew D , Armstrong Ellie E , Price Donald K , Menon Aruna R , Ali Zainab M , Whiteman Noah K 
Published: June 2019

Abstract
Horizontal gene transfer events have played a major role in the evolution of microbial species, but their importance in animals is less clear. Here, we report horizontal gene transfer of cytolethal distending toxin B (cdtB), prokaryotic genes encoding eukaryote-targeting DNase I toxins, into the genomes of vinegar flies (Diptera: Drosophilidae) and aphids (Hemiptera: Aphididae). We found insect-encoded cdtB genes are most closely related to orthologs from bacteriophage that infect Candidatus Hamiltonella defensa, a bacterial mutualistic symbiont of aphids that confers resistance to parasitoid wasps. In drosophilids, cdtB orthologs are highly expressed during the parasitoid-prone larval stage and encode a protein with ancestral DNase activity. We show that cdtB has been domesticated by diverse insects and hypothesize that it functions in defense against their natural enemies.
Systematics of the subfamily Aclyvolvinae (Caenogastropoda: Ovulidae) based on molecular and morphometric analyses
Authors: Reijnen Bastian T , van der Meij Sancia E T 
Published: June 2019

AbstractMolecular phylogenetic research on the octocoral-associated gastropod family Ovulidae is still in its infancy and, as a consequence, the relationships between subfamilies and genera are not well defined. Previous research on various ovulid genera has shown that their conchological characters are often too fluid when dealing with species delimitations. For this study, Ovulidae were collected in Indonesia and Malaysia, with some additional specimens obtained from Thailand and the Red Sea. Relationships between the Aclyvolvinae and other ovulid subfamilies were assessed using sequence data from two mitochondrial genes (cytochrome c oxidase subunit I (COI) and 16S rRNA); the dataset contained ovulid species (including type species) from the subfamilies Eocypraeinae, Ovulinae, Pediculariinae and Simniinae. The type species of the subfamilies Eocypraeinae and Sulcocypraeinae are fossils, and hence could not be included in the analyses. The phylogeny and systematics of the subfamily Aclyvolvinae were assessed based on four DNA gene regions (mitochondrial COI and 16S rRNA, and nuclear 28S rRNA and histone H3) and morphometric analyses. Shell morphological characters were analysed to help clarify species delimitations within the Aclyvolvinae. The results from the molecular analyses showed that the subfamilies Aclyvolvinae, Eocypraeinae and Simniinae are polyphyletic, whereas the Ovulinae and Pediculariinae appear to be monophyletic. Within the subfamily Aclyvolvinae, the type species of Hiatavolva, H. depressa, did not form a clade with the other species of Hiatavolva. Instead, H. rugosa and H. coarctata formed a clade that is sister to the clade comprising Aclyvolva lamyi, A. lanceolata and A. nicolamassierae, and are therefore now considered as belonging to the genus Aclyvolva. Aclyvolva lamyi and A. nicolamassierae were shown to be synonyms of A. lanceolata, and A. rugosa (n. comb.) is a synonym of A. coarctata (n. comb.). The genus Kuroshiovolva could not be retrieved in a fixed phylogenetic position within the Aclyvolvinae, nor did it cluster with H. depressa or Aclyvolva spp. Our morphometric analyses are in agreement with the results of the molecular analyses, and furthermore show that juvenile shells are morphologically significantly different from their adult conspecifics. Photographs of the type material of Ovulum lanceolatum, O. coarctatum, Neosimnia lamyi, Hiata rugosa and A. nicolamassierae are provided, and new information is given on the geographical distribution and host species of Aclyvolvinae. The subfamily Aclyvolvinae is redefined and now includes only A. lanceolata and A. coarctata. The genus Hiatavolva is now monotypic, containing only H. depressa, but the subfamily to which this genus belongs remains unclear. Kuroshiovolva is not part of the Aclyvolvinae, but its subfamily level placement is unclear.
A conserved RNA structure is essential for a satellite RNA-mediated inhibition of helper virus accumulation
Authors: He Lu , Wang Qian , Gu Zhouhang , Liao Qiansheng , Palukaitis Peter , Du Zhiyou 
Published: June 2019

Abstract
As a class of parasitic, non-coding RNAs, satellite RNAs (satRNAs) have to compete with their helper virus for limited amounts of viral and/or host resources for efficient replication, by which they usually reduce viral accumulation and symptom expression. Here, we report a cucumber mosaic virus (CMV)-associated satRNA (sat-T1) that ameliorated CMV-induced symptoms, accompanied with a significant reduction in the accumulation of viral genomic RNAs 1 and 2, which encode components of the viral replicase. Intrans replication assays suggest that the reduced accumulation is the outcome of replication competition. The structural basis of sat-T1 responsible for the inhibition of viral RNA accumulation was determined to be a three-way branched secondary structure that contains two biologically important hairpins. One is indispensable for the helper virus inhibition, and the other engages in formation of a tertiary pseudoknot structure that is essential for sat-T1 survival. The secondary structure containing the pseudoknot is the first RNA element with a biological phenotype experimentally identified in CMV satRNAs, and it is structurally conserved in most CMV satRNAs. Thus, this may be a generic method for CMV satRNAs to inhibit the accumulation of the helper virus via the newly-identified RNA structure.
Introduction
Authors: Sarch Alexander 
Published: June 2019

Abstract
This introduction outlines the general questions to be investigated in Criminally Ignorant: Why the Law Pretends We Know What We Don’t and provides a roadmap of the arguments to come. The overarching aim of the book is to defend a theory of when and why the criminal law may legitimately impute mental states on the basis of equal culpability. This helps place the existing willful ignorance doctrine on a more secure normative foundation, while at the same time revealing the pressing need for doctrinal reforms. The overall project is not limited to willful ignorance, however. The normative idea behind the willful ignorance doctrine—that we may impute missing mental states to defendants on equal culpability grounds—is surprisingly fertile, and, if taken seriously, grounds an array of further imputation principles. The book thus seeks to develop a theory that places the idea of equal culpability imputation on solid theoretical footing, while also demarcating its proper boundaries.