bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Novel and Comprehensive Wellness Assessment for Lifestyle‐Based Interventions
Authors: Ellison Katie M. , Smith Kimberly A. , Fernández José R. , Plaisance Eric P. , Chui Tsz Kiu , Hill James O. , Wyatt Holly R. , Sayer R. Drew 
Published: November 2024

ABSTRACTObjectiveWhile weight status and clinical laboratory measures are important in assessing obesity‐related disease severity and chronic disease risk, including a broader range of emotional, psychosocial, and behavioral factors would provide greater context of an individual's overall state of wellness and could be used to better guide treatment decisions. The purpose of this research was to develop a comprehensive Lifestyle Wellness assessment for use in lifestyle‐based wellness interventions and programs.MethodsA cross‐sectional exploratory factor analysis (EFA) was conducted using baseline data from N = 138 adults participating in behavioral weight loss trials. An unweighted least squares extraction method with oblique rotation was used. Twenty‐one putative measures spanning constructs related to metabolic health, emotional health/wellbeing, body weight and composition, diet quality, and fitness were analyzed for retention.ResultsMean body mass index (BMI) was 38.0 ± 6.6 kg/m2, mean age was 57.3 ± 11.1 years, and 77.5% of participants were female. The EFA produced a five‐factor model with 13 items that explained 80.3% of the variance. The retained factors included: (1) Psychosocial State: mindfulness, resilience, quality of life, and happiness; (2) Blood Pressure State: systolic and diastolic blood pressure; (3) Lipid State: total cholesterol and LDL‐cholesterol; (4) Fitness State: grip strength, jump height, and percent body fat; and (5) Body State: BMI and waist circumference.ConclusionsLifestyle Wellness is a comprehensive assessment that enables innovative wellness‐related research such as metabolically healthy obese phenotypes and weight‐neutral interventions. Future research should include investigations in additional populations with greater age, sex/gender, and body size diversity.
AMIGO2 characterizes cancer‐associated fibroblasts in metastatic colon cancer and induces the release of paracrine active tumorigenic secretomes
Authors: Yong Yongsong , Demmler Richard , Zohud Bisan Abdalfatah , Fang Qi , Zhang Tong , Zhou Yonghua , Petter Katja , Flierl Christian , Gass Tobias , Geppert Carol I , Merkel Susanne , Schellerer Vera S , Naschberger Elisabeth , Stürzl Michael 
Published: November 2024

AbstractSecretomes of cancer‐associated fibroblasts (CAFs) in colorectal cancer (CRC) contribute to malignancy. Detailed knowledge is available on the components and functions of CAF secretomes. Little is known about the regulation of CAF secretomes. Here, we searched for receptor‐like membrane‐bound molecules in CAFs, which may regulate the production and release of tumor‐activating secretomes. The adhesion molecule with Ig‐like domain 2 (AMIGO2) was significantly upregulated in cultivated CAFs compared to normal tissue‐associated fibroblasts (NAFs), and this was confirmed in patient‐derived tissues. AMIGO2 expression was low or absent in healthy colon, significantly increased in fibroblasts of primary CRC, and highest in the stromal tissues of CRC‐derived liver metastases. AMIGO2 expression in CAFs correlated with a higher T‐category, increased lymph node metastasis, progressed tumor stages and was associated with reduced survival in different cohorts of CRC patients. Interestingly, AMIGO2 expression was induced by transforming growth factor‐β and higher in female patients, who exhibit a more aggressive disease course. In functional studies, conditioned media of NAFs with experimentally induced AMIGO2 overexpression enhanced proliferation and migration of different CRC tumor cells, while siRNA‐mediated inhibition of AMIGO2 in CAFs attenuated these effects. Accordingly, therapeutic inhibition of the receptor‐like AMIGO2 protein in CRC CAFs could prevent tumorigenic secretomes in CRC. © 2024 The Author(s). The Journal of Pathology published by John Wiley & Sons Ltd on behalf of The Pathological Society of Great Britain and Ireland.
Predictors of Selective Serotonin Reuptake Inhibitor Treatment Failure in Persons With Cystic Fibrosis
Authors: Pettit Rebecca S. , Sakon Coleen M. , Kinney Kaitlyn E. , Brown Cynthia , Gallaway Katherine A. , Wagner Sarah A. , Tillman Emma M. 
Published: November 2024

ABSTRACTIntroductionDepression and anxiety are common in persons with cystic fibrosis (PwCF). Genetic polymorphisms in CYP2C19 and CYP2D6 are well‐established predictors of selective serotonin reuptake inhibitors (SSRIs) treatment failure yet have not been studied specifically in PwCF. The purpose of this study was to determine the rate of SSRI failure in PwCF and to identify factors that predict treatment failure.MethodsA retrospective cohort study was conducted of PwCF prescribed an SSRI for depression or anxiety. Potential predictors of SSRI failure were compared between PwCF for SSRI treatment success and failure. When CYP2D6 and CYP2C19 pharmacogenetic (PGx) test results were available, SSRI selection was compared to appropriateness per Clinical PGx Implementation Consortium (CPIC) guideline. PGx results were not available at the time of prescribing.ResultsThe study included 184 PwCF and 45% experienced SSRI treatment failure. Demographics, concomitant drug‐drug interactions, concomitant antidepressant medications, liver disease, and pulmonary function tests were not different between success and failure groups. Only 44 PwCF had PGx results and of these, only nine had actionable genotypes and prescribed an affected SSRI. This cohort had a failure rate of 78% (7 of 9) which was significantly higher compared to 40% (14 of 35) and 45% (83 of 184) in our PGx cohort and total cohort, respectively (p = 0.04; p = 0.04).ConclusionSSRI failure rate in PwCF is high and consistent with rates of the general population. Greater depression severity and number of SSRIs trialed were seen in the failure group. Pre‐emptive PGx testing may improve SSRI success rates in PwCF.
pSTAT3 Expression is Increased in Advanced Prostate Cancer in Post‐Initiation of Androgen Deprivation Therapy
Authors: Bialas Piotr , Kobayashi Tamae , Hellsten Rebecka , Krzyzanowska Agnieszka , Persson Margareta , Marginean Felicia , Trudel Dominique , Garraway Isla P. , Trock Bruce J. , Taimen Pekka , Saad Fred , Mirtti Tuomas , Knudsen Beatrice , De Marzo Angelo M. , Bjartell Anders 
Published: November 2024

ABSTRACTBackgroundThe transcription factor Signal Transducer and Activator of Transcription 3 (STAT3) plays a role in carcinogenesis and is involved in processes, such as proliferation, differentiation, drug resistance and immunosuppression. STAT3 can be activated by phosphorylation of tyrosine at position 705 (pSTAT3Tyr705) or serine at 727 (pSTAT3Ser727). High expression levels of pSTAT3 are implicated in advanced stages of prostate cancer (PCa) and are known to interact with the androgen receptor signaling pathway. However, not much is known about how androgen deprivation therapy (ADT) in advanced disease affects pSTAT3 expression. The aim of this study was to determine the influence of ADT on pSTAT3 expression in PCa tissue.MethodsThe study cohort came from a PCa tissue microarray resource containing prostate specimens from patients before and post‐initiation of ADT. Tissue samples from 111 patients were immunostained for pSTAT3Tyr705 and pSTAT3Ser727. H‐score was used to evaluate the intensity and the percentage of pSTAT3 expression in malignant epithelial and stromal compartments. Univariate and multivariable Cox regression analyses were used to assess pSTAT3Tyr705 and pSTAT3Ser727 as biomarkers of oncological outcome in patients undergoing ADT.ResultsPost‐ADT PCa samples demonstrated increased nuclear and cytoplasmic levels of pSTAT3Ser727 in the stroma compared to pre‐ADT samples, whereas pSTAT3Tyr705 expression was increased significantly in both stromal and malignant epithelial compartments except for stromal cytoplasm. High cytoplasmic pSTAT3Ser727 in stromal compartments correlated with reduced overall survival, shorter time to castration‐resistant PCa development, and decreased metastasis‐free survival. An increase in nuclear and cytoplasmic pSTAT3Ser727 expression within the stromal compartment of post‐ADT samples corresponded to a shorter time to CRPC development, which was not observed for pSTAT3Tyr705. Multivariable survival analysis using Cox's regression identified that high cytoplasmic pSTAT3Ser727 expression in the stroma of post‐ADT samples and pT3 or pT4‐stage were associated with worse overall survival and 5‐year metastasis‐free survival (MFS).ConclusionsThis study presents novel insights into the impact of ADT on the expression levels of pSTAT3Tyr705 and pSTAT3Ser727 in PCa. Cytoplasmic pSTAT3Ser727 status of cancer‐associated stromal cells in post‐ADT samples may serve as an independent prognostic marker for OS and 5‐year MFS, identifying prostate cancer patients prone to developing resistance to ADT.
Mechanical Dynamics Around Higher‐Order Exceptional Point in Magno‐Optomechanics
Authors: He Wen‐Di , Fan Xiao‐Hong , Liu Ming‐Yue , Zhang Guo‐Qiang , Li Hai‐Chao , Xiong Wei 
Published: November 2024

AbstractDiverse exceptional points (EPs) are theoretically studied in an experimentally feasible magno‐optomechanics consisting of an optomechanical subsystem coupled to a magnomechanical subsystem via physically direct contact. By adiabatically eliminating both the cavity and the Kittel mode, dissipative and parity‐time symmetric exceptional points can be observed. When only the cavity mode is eliminated, a second (third)‐order pseudo‐Hermitian EP emerges for nondegenerate (degenerate) mechanical modes. The distinct dynamical behavior of two mechanical modes around these EPs are further studied. The proposal provides a promising way to engineer diverse EPs and quantify non‐Hermitian phase transition with exceptional dynamical behavior in magno‐optomechanics.
Enteric Methane Production, Yield, and Intensity in Smallholder Dairy Farming Systems in Peri‐Urban Areas of Coastal West African Countries: Case Study of Benin
Authors: Yassegoungbe Fifame Panine , Vihowanou Gaius Segbegnon , Onanyemi Tawakalitu , Assouma Mohamed Habibou , Schlecht Eva , Dossa Luc Hippolyte 
Published: November 2024

ABSTRACTEnteric methane (eCH4) is a major environmental pollutant emitted by ruminants. To target mitigation measures, it is necessary to accurately estimate GHG emissions from livestock farming. Until now, milk‐producing farms in the peri‐urban areas of South Benin are pasture‐based systems, and have been largely neglected by international research. Therefore, this study estimates eCH4 emissions from pasture‐based peri‐urban dairy farms across four different animal categories during dry and wet seasons. Six herds were selected for field measurements; one representative animal was selected per category from each herd and its body weight estimated. Subsequently, the selected animals were closely monitored on pasture for three consecutive days. Direct observation of their behavior and the hand‐plucking method were used to mimic the animals' selective foraging and to sample parts of the different plant species consumed in proportion to their, to determine the quality of their daily diet. The nutrient content and digestibility of the collected feed samples were assessed using near‐infrared spectroscopy. Additionally, 30 herds were monitored bi‐monthly during a 12‐month period to collect all input and output data, including milk yields. Annual enteric methane (eCH4) emissions per animal category were estimated using the IPCC Tier 2 method. Subsequently, the eCH4 intensities of lactating cows were calculated per kg of fat‐protein corrected milk (FPCM). All statistical analyses were performed using R software. Overall, the average annual eCH4 production was 40.6 kg/head/year and the eCH4 yield was 20.3 g/kg of dry matter intake, with significant differences between seasons and no differences between animal categories. Regardless of season, older animals yielded higher eCH4 outputs. The average eCH4 production per kg of live weight was 0.48 g for both seasons. The overall eCH4 intensity (g CH4/kg FPCM) recorded during the wet season (74.3) was higher than that recorded during the dry season (70.5).
Antidiabetic, Antioxidant, Antinociceptive, and Anti‐Inflammatory Potential of Chemically Characterized Extract of Limeum Indicum Stocks ex T. Anderson (Aizoaceae). In Vitro, In Vivo, and In Silico Investigations
Authors: Imran Rukhsar , Peerzada Sohaib , Anjum Irfan , Bilal Hafiz Muhammad , Raza Moosa , Siddique Farhan , Bashir Maryam , Jardan Yousef A. Bin , Waqar Maham , Shazly Gamal A. , Bourhia Mohammed 
Published: November 2024

AbstractLimeum indicum (LI), a plant from the Aizoaceae family, has garnered interest due to its potential health benefits. In this study, we explore the antidiabetic, antioxidant, antinociceptive, and anti‐inflammatory properties of a chemically characterized whole extract from LI. In vitro assays included DPPH and reducing power tests to assess antioxidant activity. For in vivo investigations, adult Wistar rats were used. Alloxan‐induced diabetic rats received oral doses of LI whole extract (ethanol (LI‐EE), DCM (LI‐DE), and n‐Hexane (LI‐HE)) or glimepiride for 21 days. Carrageenan‐induced inflammation and nociceptive effects were also evaluated. Molecular docking studies aided in identifying potential targets for the extract's bioactivity. Phytochemical analysis revealed the presence of cardiac glycosides, flavonoids, phenolics, saponins, and fixed oils in the extract. Both DPPH and reducing power assays demonstrated substantial total phenolic and flavonoid content, indicative of strong antioxidant activity. The extracts dose‐dependently reduced blood glucose levels in alloxan‐induced diabetic rats and mitigated inflammation and nociception. Furthermore, the significant antidiabetic and anti‐inflammatory activities of n‐hexane extract, suggested to identify the potential components by employing molecular docking studies.
Synthesis of Sodium Carbonate Based Solid Adsorbents and Their CO2 Adsorption Performance
Authors: Liu Kaiqiang , Adili Guliqire , Ding Zijun , Tuergong Nueraminai , Shi Jiahong , Tuersun Aminamu , Aihaiti Hurexida , Nasiman Tuerxun 
Published: November 2024

AbstractPorous carbon is considered a promising adsorbent for carbon capture and sequestration, and pore structure and surface activity must be optimized in order to achieve high capture capacity and recycling performance. In this study, terephthalic acid and sodium hydroxide were used as raw materials to prepare sodium carbonate based porous carbon and metal oxide composites at TPA:NaOH:X(X = MgO, CaO, MgO/CaO, Mg(NO3)2,C, and Al2O3) = 1:1:2 and 600 °C. The analysis results show that the material MgO/Na2CO3 has the best CO2 adsorption capacity, and the adsorption capacity is 10.56cm3/g at 0 °C and 1 bar. The material Al2O3/Na2CO3 has the best thermal stability, and the MgO/Na2CO3 shows good recycling performance in the five cycle test. The high‐temperature calcination process makes the mesoporous structure of the material form, which makes the carbon composites show good capture performance, and sodium carbonate based solid adsorbents have good development and application prospects as CO2 capture and separation materials.
Metal‐Free Photooxidation of Toluene Derivatives into the Corresponding Carboxylic Acids and Aldehydes by a HBr/NaOCl·5H2O System
Authors: Kirihara Masayuki , Kawai Takuma , Kitajima Atsuhito , Yamahara Sho , Mori Nena , Kimura Yoshikazu 
Published: November 2024

AbstractPhotobromination of toluene derivatives using blue LED (454 nm) or UV LEDs (365, 385, 395 nm) with aqueous HBr and NaOCl·5H2O in trifluoromethyl benzene afforded the corresponding benzoic acids derivatives. The intermediates were (dibromomethyl)benzene derivatives, isolated in a nitrogen atmosphere. The dibromomethyl benzene derivatives afforded the corresponding aldehydes. After the reaction with HBr, the aqueous layer could be recovered and reused.
Recent Advancements in Benzothiazinones (BTZ) Analogs as DprE1 Inhibitor for Potent Antitubercular Therapeutics
Authors: Sonawane Kalyani , Said Rushikesh , Lele Mukta , Chaudhari Hemchandra , Hatvate Navnath 
Published: November 2024

AbstractBenzothiazinone analogs have emerged as a promising class of compounds having potent antimycobacterial activity, particularly against Mycobacterium tuberculosis, the pathogen responsible for tuberculosis. This review highlights the development of benzothiazinone analogs as potential antitubercular agents from the beginning to the recent advancement in the past decade. These compounds have shown potent activity, including drug‐resistant strains of Mycobacterium tuberculosis. Structure–activity relationship studies and modifications have improved their efficacy. Benzothiazinone analogs have favorable pharmacokinetic profiles and show promise in preclinical studies. Challenges include addressing resistance mechanisms and ensuring safety. Their unique mode of action and promising properties make them attractive candidates for the battle against drug‐resistant tuberculosis.
Synthesis and Ocular Hypotensive Properties 3(4)‐Alkyl‐[1,2,4]triazolo[1,5‐a]pyrimidin‐7‐amines
Authors: Ushakova Angelina A. , Fedotov Victor V. , Drokin Roman A. , Ulomsky Evgeniy N. , Rusinov Vladimir L. , Spasov Alexander A. , Naumenko Lyudmila V. , Taran Alyona S. , Chebanko Alina M. , Yakovlev Dmitry S. , Pshenichnikova Maria S. 
Published: November 2024

AbstractGlaucoma is one of the major causes of irreversible blindness worldwide. Increased intraocular pressure (IOP) is a key factor in the onset and progression of this disease. The drugs used to treat glaucoma influence a variety of biological targets. Azolopyrimidine derivatives have attracted significant attention as potential agents for the treatment of glaucoma because they presumed to be analogs of adenosine receptor (AR) agonists and antagonists. In this study, a series of novel 3(4)‐alkyl‐[1,2,4]triazolo[1,5‐a]pyrimidin‐7‐amines were synthesized to develop promising ophthalmic hypotensive drugs. The synthesized compounds demonstrated significant hypotensive activity against IOP, which opens new possibilities for glaucoma therapy.
Magnetically Propelled Microrobots toward Photosynthesis of Green Ammonia from Nitrates
Authors: Mallick Apabrita , Kim Jeonghyo , Pumera Martin 
Published: November 2024

AbstractAmmonia (NH₃) production is a critical industrial process, as ammonia is a key component in fertilizers, essential for global agriculture and food production. However, the current method of synthesizing ammonia, the Haber‐Bosch process, is highly energy‐intensive, and relies on fossil fuels, contributing substantially to greenhouse gas emissions. Moreover, the centralized nature of the Haber‐Bosch process limits its accessibility in remote or resource‐limited areas. Photochemical synthesis of ammonia, provides an alternate lower energy, carbon‐free pathway compared to the prevailing industrial methods. The photoconversion of nitrate anions, often present in wastewater, offers a greener, more sustainable, and energy‐efficient route for both ammonia‐generation and wastewater treatment. Photochemical and chemical synthesis of ammonia requires intensive mass‐transfer processes, which limits the efficiency of the method. To change the game, in this work, a key new technology of ammonia‐generation, a catalytic ammonia generation (AmmoGen) microrobot, which converts nitrate to ammonia using renewable light energy is reported. The magnetic propulsion of the AmmoGen microrobots significantly enhances mass‐transfer, and expedites the photosynthesis of ammonia. Overall, this “proof‐of‐concept” study demonstrates that microrobots can aid in catalytic small molecule activation and generation of value‐added products; and are envisaged to pave the way toward new sustainable technologies for catalysis.
Understanding the Spin of Metal Complexes from a Single‐Molecule Perspective
Authors: Guo Jie , Gao Qinghua , Gao Fei , Jia Chuancheng , Guo Xuefeng 
Published: November 2024

AbstractCompared with aggregate spin behavior, single‐molecule spin behavior can be accurately understood, controlled, and applied at the level of basic building blocks. The potential of single‐molecule electronic and nuclear spins for monitoring and control represents a beacon of promise for the advancement of molecular spin devices, which are fabricated by connecting a single molecule between two electrodes. Metal complexes, celebrated for their superior magnetic attributes, are widely used in the devices to explore spin effects. Moreover, single‐molecule electrical techniques with high signal‐to‐noise ratio, temporal resolution, and reliability help to understand the spin characteristics. In this review, the focus is on the devices with metal complexes, especially single‐molecule magnets, and systematically present experimental and theoretical state of the art of this field at the single‐molecule level, including the fundamental concepts of the electronic and nuclear spin and their basic spin effects. Then, several experimental methods developed to regulate the spin characteristics of metal complexes at single‐molecule level are introduced, as well as the corresponding intrinsic mechanisms. A brief discussion is provided on the comprehensive applications and the considerable challenges of single‐molecule spin devices in detail, along with a prospect on the potential future directions of this field.
A Versatile Method for Preparation of BrCOFs Aerogels and Efficient Functionalization via Suzuki–Miyaura Reaction
Authors: Wang Qiaomu , Wang Peng , Wang Yandong , Xu Yang , Xu Haocheng , Xi Kai 
Published: November 2024

AbstractCovalent organic frameworks (COFs) aerogels solve the restrictions on processability and application caused by the insolubility and non‐fusibility of powders while avoiding the inaccessibility of pore structures by dense stacking. At the current start‐up stage where COFs aerogels are scarce and difficult to synthesize, design of generalized synthetic methods play an indispensable role in guiding and developing COFs aerogels. Moreover, evolving the functionality of COF aerogels is equal vital, which achieves higher performance and broader practical applications. In this work, for the first time, processable BrCOFs aerogels have been synthesized without vacuum by seven kind polar solvents, which realizes general preparation of BrCOFs aerogels. It is extremely friendly to the inapplicability for some scenarios. Furthermore, by Suzuki‐Miyaura cross‐coupling reaction, BrCOFs aerogels are endows with cyano groups (‐CN), trifluoromethyl (‐CF3) and methyl sulfonyl (‐SO2‐CH3) efficiently. As a proof‐of‐concept, BrCOFs‐SO2‐CH3 aerogels served as a quasi‐solid electrolyte for lithium‐metal batteries (LMBs), which effectively enhance the performance of batteries.
NH4Cl‐Assisted Electrosynthesis of P‐Doped Co(OH)2 Nanosheet on Cu2S Hollow Nanotube Arrays for Glycerol Electrooxidation
Authors: Xu Haitao , Zhang Hao , Luo Yan , Zhao Jingzhe , Li Feng 
Published: November 2024

AbstractThe glycerol oxidation reaction (GOR) for producing high‐value‐added organic compounds is of great research interest due to its potential in alleviating the energy crisis. Herein, a facile NH4Cl‐assisted electrodeposition strategy is reported to fabricate 3D nano‐forest array‐like hollow nanostructures. The hierarchical heterojunction by combining phosphorus doping Co(OH)2 nanosheets with Cu2S nanotube arrays (P‐Co(OH)2@Cu2S NTs/CF) is developed to realize the optimization on GOR. The optimized P‐Co(OH)2@Cu2S NTs/CF catalyst exhibits an exceptional activity with a formate Faradaic efficiency (FE) of 97.40% at a potential of 1.30 V (vs RHE). The experimental results indicate that this unique hollow nano‐forest structure, grown on a conductive support, can expose more active sites and facilitate electron transfer, thereby demonstrating excellent GOR performance. This work provides new opportunities for the design of electrocatalysts of high‐activity and low‐cost hollow heterostructure electrocatalysts for glycerol electrooxidation.