bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effectiveness of psychotherapies that engage with the voices of Voice Hearers: a systematic review protocol
Authors: Scott Wendy , McArthur Alexa , Tufanaru Catalin 
Published: June 2018

Review objectives/questions
The objective of this review is to identify, evaluate and synthesize relevant research on the effectiveness of psychotherapies that engage Voice Hearers with their voices in order to change the person's quality of life, recovery, coping and distress. More specifically, the objective is to ascertain the effectiveness of this type of intervention with or without any other co-intervention, either pharmacological or non-pharmacological, compared to treatment as usual, for people from a Western or European culture aged 18–65 years who hear voices, regardless of ethnicity.
Criteria used for diagnosis of adhesive capsulitis of the shoulder: a scoping review protocol
Authors: Lee Michael , Theodoulou Annika , Krishnan Jeganath 
Published: June 2018

Review objective:
The objective of this scoping review is to locate and summarize the current criteria used in the diagnosis of adhesive capsulitis of the shoulder in recent academic literature. Furthermore, we aim to explore differences, if any, in the criteria used across treating professions, study country of origin and study level of evidence.
CNG for Commercial, Law Enforcement and Recreational Boats
Authors: Guerreiro Miguel 
Published: June 2018

CNG has significant environmental and economic advantages as a marine fuel in commercial applications as well as law enforcement and recreational use. This paper covers the current technical and business aspects of the current deployment of CNG marine systems for boat propulsion, on-board power generation, fueling operation and the practical considerations that make it all possible today for the different use of boats. The technology and its benefits are reviewed and measurements from existing CNG hybrid boats currently in operation are analyzed.
Paper published with permission.
Missed opportunities for HIV testing among patients newly presenting for HIV care at a Swiss university hospital: a retrospective analysis
Authors: Lhopitallier Loïc , Moulin Estelle , Hugli Olivier , Cavassini Matthias , Darling Katharine Elizabeth Anna 
Published: June 2018

ObjectivesTo determine the frequency of missed opportunities (MOs) among patients newly diagnosed with HIV, risk factors for presenting MOs and the association between MOs and late presentation (LP) to care.DesignRetrospective analysis.SettingHIV outpatient clinic at a Swiss tertiary hospital.ParticipantsPatients aged ≥18 years newly presenting for HIV care between 2010 and 2015.MeasuresNumber of medical visits, up to 5 years preceding HIV diagnosis, at which HIV testing had been indicated, according to Swiss HIV testing recommendations. A visit at which testing was indicated but not performed was considered an MO for HIV testing.ResultsComplete records were available for all 201 new patients of whom 51% were male and 33% from sub-Saharan Africa. Thirty patients (15%) presented with acute HIV infection while 119 patients (59%) were LPs (CD4 counts <350 cells/mm3at diagnosis). Ninety-four patients (47%) had presented at least one MO, of whom 44 (47%) had multiple MOs. MOs were more frequent among individuals from sub-Saharan Africa, men who have sex with men and patients under follow-up for chronic disease. MOs were less frequent in LPs than non-LPs (42.5% vs 57.5%, p=0.03).ConclusionsAt our centre, 47% of patients presented at least one MO. While our LP rate was higher than the national figure of 49.8%, LPs were less likely to experience MOs, suggesting that these patients were diagnosed late through presenting late, rather than through being failed by our hospital. We conclude that, in addition to optimising provider-initiated testing, access to testing must be improved among patients who are unaware that they are at HIV risk and who do not seek healthcare.
Development and internal validation of a multivariable prediction model for tinnitus recovery following unilateral cochlear implantation: a cross-sectional retrospective study
Authors: Ramakers Geerte G J , van Zanten Gijsbert A , Thomeer Hans G X M , Stokroos Robert J , Heymans Martijn W , Stegeman Inge 
Published: June 2018

ObjectiveTo develop and internally validate a prediction model for tinnitus recovery following unilateral cochlear implantation.DesignA cross-sectional retrospective study.SettingA questionnaire concerning tinnitus was sent to patients with bilateral severe to profound hearing loss, who underwent unilateral cochlear implantation at the University Medical Center Utrecht, the Netherlands, between 1 January 2006 and 31 December 2015.ParticipantsOf 137 included patients, 87 patients experienced tinnitus preoperatively. Data of these 87 patients were used to develop the prediction model.Primary and secondary outcome measuresThe outcome of the prediction model was tinnitus recovery. Investigated predictors were: age, gender, duration of deafness, preoperative hearing performance, tinnitus duration, severity and localisation, follow-up duration, localisation of cochlear implant (CI) compared with tinnitus side, surgical approach, insertion depth of the electrode, CI brand and difference in hearing threshold following cochlear implantation. Multivariable backward logistic regression was performed. Missing data were handled using multiple imputation. The performance of the model was assessed by the calibrative and discriminative ability of the model. The prediction model was internally validated using bootstrapping techniques.ResultsThe tinnitus recovery rate was 40%. A lower preoperative Consonant-Vowel-Consonant (CVC) score, unilateral localisation of tinnitus and larger deterioration of residual hearing at 250 Hz revealed to be relevant predictors for tinnitus recovery. The area under the receiver operating characteristics curve (AUC) of the initial model was 0.722 (IQR: 0.703–0.729). After internal validation of this prediction model, the AUC decreased to 0.696 (IQR: 0.667–0.700).Conclusion and relevanceLower preoperative CVC score, unilateral localisation of tinnitus and larger deterioration of residual hearing at 250 Hz were significant predictors for tinnitus recovery following unilateral cochlear implantation. The performance of the model developed in this retrospective study is promising. However, before clinical use of the model, the conduction of a larger prospective study is recommended.
A Better Alternative to a Trade War
Authors: Lau Lawrence J. 
Published: June 2018

Reducing the US-China trade deficit through the imposition of tariffs on Chinese exports to the US risks retaliatory tariffs by China. The net result may be an involuntary reduction of trade between them which lowers the aggregate welfare in both countries. It will be lose-lose. Moreover, the most likely net outcome of these new country-specific tariffs is the substitution of imports from China by imports from other countries on the part of US importers. Thus, while the US trade deficit with China falls, its trade deficit with other countries will rise. The overall US trade deficit with the rest of the world will not be significantly altered. Almost all economists agree that the aggregate US trade deficit with the rest of the world cannot be reduced without a corresponding reduction in the US investment-saving imbalance, taking the US real GDP as given. However, there is an exception: if there is an autonomous (unanticipated) increase in the demand for exports from the US which increases the real GDP of the US in the process, it is possible for the US trade deficit to be reduced. Indeed, a huge potential exists for the US to substantially increase its exports of agricultural commodities, energy, and education and tourism services to China. Finally, we address the question of what constitutes “fair trade”. There does not seem to be a generally accepted economic definition of “fairness”. Any completely voluntary and non-coercive trade at the prevailing market price should be regarded as “fair”.
A modelling study of the variation of thermal conductivity of the English Chalk
Authors: Busby Jon 
Published: June 2018

Thermal conductivity is required when designing ground heating and cooling schemes, electrical cable conduits and tunnel ventilation. In England these infrastructures are often emplaced within the Chalk. To improve knowledge on chalk thermal conductivity, over the few scattered measured values, estimates have been made from multi-component mixture models based on the mineral composition, porosity and the structure of the Chalk. The range in mid values for the thermal conductivities is 1.78–2.57 W m
−1
K
−1
where the lowest values are for the Upper Chalk. Variations in porosity are the main factor for the variation in thermal conductivity. The effect of fracturing is to reduce the bulk thermal conductivity, but the reduction is small for fractures that are saturated. For an averagely fractured chalk with 60% fracture saturation, the reduction in thermal conductivity is around 22% for a thermal conductivity of 2.15 W m
−1
K
−1
. In the near-surface zone, where fracture apertures will be at their greatest and unsaturated conditions may prevail for part of the year, the seasonal variation in thermal conductivity may be significant for infrastructure design.
Integrative Genome-Wide Analysis of Long Noncoding RNAs in Diverse Immune Cell Types of Melanoma Patients
Authors: Wang Lei , Felts Sara J. , Van Keulen Virginia P. , Scheid Adam D. , Block Matthew S. , Markovic Svetomir N. , Pease Larry R. , Zhang Yuji 
Published: June 2018

Abstract
Genome-wide identification and characterization of long noncoding RNAs (lncRNA) in individual immune cell lineages helps us better understand the driving mechanisms behind melanoma and advance personalized patient treatment. To elucidate the transcriptional landscape in diverse immune cell types of peripheral blood cells (PBC) in stage IV melanoma, we used whole transcriptome RNA sequencing to profile lncRNAs in CD4+, CD8+, and CD14+ PBC from 132 patient samples. Our integrative computational approach identified 27,625 expressed lncRNAs, 2,744 of which were novel. Both T cells (i.e., CD4+ and CD8+ PBC) and monocytes (i.e., CD14+ PBC) exhibited differential transcriptional expression profiles between patients with melanoma and healthy subjects. Cis- and trans-level coexpression analysis suggested that lncRNAs are potentially involved in many important immune-related pathways and the programmed cell death receptor 1 checkpoint pathways. We also identified nine gene coexpression modules significantly associated with melanoma status, all of which were significantly enriched for three mRNA translation processes. Age and melanoma traits closely correlated with each other, implying that melanoma contains age-associated immune changes. Our computational prediction analysis suggests that many cis- and trans-regulatory lncRNAs could interact with multiple transcriptional and posttranscriptional regulatory elements in CD4+, CD8+, and CD14+ PBC, respectively. These results provide novel insights into the regulatory mechanisms involving lncRNAs in individual immune cell types in melanoma and can help expedite cell type-specific immunotherapy treatments for such diseases.
Significance: These findings elucidate melanoma-associated changes to the noncoding transcriptional landscape of distinct immune cell classes, thus providing cell type-specific guidance to targeted immunotherapy regimens. Cancer Res; 78(15); 4411–23. ©2018 AACR.
Safety and Efficacy of Anlotinib, a Multikinase Angiogenesis Inhibitor, in Patients with Refractory Metastatic Soft-Tissue Sarcoma
Authors: Chi Yihebali , Fang Zhiwei , Hong Xiaonan , Yao Yang , Sun Ping , Wang Guowen , Du Feng , Sun Yongkun , Wu Qiong , Qu Guofan , Wang Shusen , Song Jianmin , Yu Jianchun , Lu Yongkui , Zhu Xia , Niu Xiaohui , He Zhiyong , Wang Jinwan , Yu Hao , Cai Jianqiang 
Published: June 2018

Abstract
Purpose: The prognosis for patients with refractory soft-tissue sarcoma (STS) is dismal. Anlotinib has previously shown antitumor activity on STS in preclinical and phase I studies.
Patients and Methods: Patients 18 years and older, progressing after anthracycline-based chemotherapy, naïve from angiogenesis inhibitors, with at least one measurable lesion according to RECIST 1.1, were enrolled. The main subtypes eligible were undifferentiated pleomorphic sarcoma (UPS), liposarcoma (LPS), leiomyosarcoma (LMS), synovial sarcoma (SS), fibrosarcoma (FS), alveolar soft-part sarcoma (ASPS), and clear cell sarcoma (CCS). Participants were treated with anlotinib. The primary endpoint was progression-free rate at 12 weeks (PFR12 weeks).
Results: A total of 166 patients were included in the final analysis. Overall, the PFR12 weeks was 68%, and objective response rate was 13% (95% confidence interval, 7.6%–18%). The median progression-free survival (PFS) and overall survival (OS) were 5.6 and 12 months, respectively. The PFR12 weeks, median PFS and OS were: 58%, 4.1 and 11 months for UPS (n = 19); 63%, 5.6 and 13 months for LPS (n = 13); 75%, 11 and 15 months for LMS (n = 26); 75%, 7.7 and 12 months for SS (n = 47); 81%, 5.6 and 12 months for FS (n = 18); 77%, 21 and not reached for ASPS (n = 13); 54%, 11 and 16 months for CCS (n = 7); and 44%, 2.8 and 8.8 months for other sarcoma (n = 23), respectively. The most common clinically significant grade 3 or higher adverse events were hypertension (4.8%), triglyceride elevation (3.6%), and pneumothorax (2.4%). No treatment-related death occurred.
Conclusions: Anlotinib showed antitumor activity in several STS entities. The toxicity was manageable. Clin Cancer Res; 24(21); 5233–8. ©2018 AACR.
Primary T Cells from Cutaneous T-cell Lymphoma Skin Explants Display an Exhausted Immune Checkpoint Profile
Authors: Querfeld Christiane , Leung Samantha , Myskowski Patricia L. , Curran Shane A. , Goldman Debra A. , Heller Glenn , Wu Xiwei , Kil Sung Hee , Sharma Sneh , Finn Kathleen J. , Horwitz Steven , Moskowitz Alison , Mehrara Babak , Rosen Steven T. , Halpern Allan C. , Young James W. 
Published: June 2018

Abstract
Cutaneous T-cell lymphoma (CTCL) develops from clonally expanded CD4+ T cells in a background of chronic inflammation. Although dendritic cells (DCs) stimulate T cells and are present in skin, cutaneous T cells in CTCL do not respond with effective antitumor immunity. We evaluated primary T-cell and DC émigrés from epidermal and dermal explant cultures of skin biopsies from CTCL patients (n = 37) and healthy donors (n = 5). Compared with healthy skin, CD4+ CTCL populations contained more T cells expressing PD-1, CTLA-4, and LAG-3. CD8+ CTCL populations contained more T cells expressing CTLA-4 and LAG-3. CTCL populations also contained more T cells expressing the inducible T-cell costimulator (ICOS), a marker of T-cell activation. DC émigrés from healthy or CTCL skin biopsies expressed PD-L1, indicating that maturation during migration resulted in PD-L1 expression irrespective of disease. Most T cells did not express PD-L1. Using skin samples from 49 additional CTCL patients for an unsupervised analysis of genome-wide mRNA expression profiles corroborated that advanced T3/T4-stage samples expressed more checkpoint inhibition mRNA compared with T1/T2 stage patients or healthy controls. Exhaustion of activated T cells is therefore a hallmark of both CD4+ and CD8+ T cells isolated from the lesional skin of patients with CTCL, with increasing expression as the disease progresses. These results justify identification of antigens driving T-cell exhaustion and the evaluation of immune checkpoint inhibition to reverse T-cell exhaustion earlier in the treatment of CTCL. Cancer Immunol Res; 6(8); 900–9. ©2018 AACR.
The Mutation-Associated Neoantigen Functional Expansion of Specific T Cells (MANAFEST) Assay: A Sensitive Platform for Monitoring Antitumor Immunity
Authors: Danilova Ludmila , Anagnostou Valsamo , Caushi Justina X. , Sidhom John-William , Guo Haidan , Chan Hok Yee , Suri Prerna , Tam Ada , Zhang Jiajia , Asmar Margueritta El , Marrone Kristen A. , Naidoo Jarushka , Brahmer Julie R. , Forde Patrick M. , Baras Alexander S. , Cope Leslie , Velculescu Victor E. , Pardoll Drew M. , Housseau Franck , Smith Kellie N. 
Published: June 2018

AbstractMutation-associated neoantigens (MANA) are a target of antitumor T-cell immunity. Sensitive, simple, and standardized assays are needed to assess the repertoire of functional MANA-specific T cells in oncology. Assays analyzing in vitro cytokine production such as ELISpot and intracellular cytokine staining have been useful but have limited sensitivity in assessing tumor-specific T-cell responses and do not analyze antigen-specific T-cell repertoires. The FEST (Functional Expansion of Specific T cells) assay described herein integrates T-cell receptor sequencing of short-term, peptide-stimulated cultures with a bioinformatic platform to identify antigen-specific clonotypic amplifications. This assay can be adapted for all types of antigens, including MANAs via tumor exome-guided prediction of MANAs. Following in vitro identification by the MANAFEST assay, the MANA-specific CDR3 sequence can be used as a molecular barcode to detect and monitor the dynamics of these clonotypes in blood, tumor, and normal tissue of patients receiving immunotherapy. MANAFEST is compatible with high-throughput routine clinical and lab practices. Cancer Immunol Res; 6(8); 888–99. ©2018 AACR.
Overactive Bladder Symptoms after Transobturator Sling Surgery for Pure Stress Urinary Incontinence: A Cross-Sectional Comparative Study
Authors: Pereira e Silva Ricardo , Gomes Olival Vanessa , Ponte Carolina , Palma dos Reis José , Colaço João , Grilo Isabel , Nunes Filomena 
Published: June 2018

<b><i>Introduction:</i></b> Transobturator tape (TOT) surgery has been associated with increased overactive bladder (OAB) although much controversy exists. <b><i>Methods:</i></b> In a cross-sectional study, women who underwent TOT surgery for pure stress incontinence (Monarc<sup>TM</sup>) answered the 6 questions of the symptom bother (SB) subscale of the OAB questionnaire – short form (OABq-SF) and an additional question regarding whether symptoms began after surgery. Women with SB score over the 4th quartile (≥30/100) were reassessed after a longer follow-up. Patients from primary care were recruited as controls. <b><i>Results:</i></b> We recruited 213 patients (135 in the TOT group and 78 age-adjusted controls). The mean age of operated patients was 58.7 ± 10.1 years with a mean follow-up of 25.9 ± 13.2 months. OABq-SF SB scores did not differ between the TOT group and controls (respectively, 18.5 ± 30 and 15.5 ± 6.7, <i>p</i> = 0.202). A total of 48% patients reported no relationship between symptoms and surgery. Highly symptomatic operated patients were reassessed after a longer follow-up (46.3 ± 10.6 months). The mean score in the second follow-up (<i>n</i> = 25) was not statistically different from the first assessment (46.4 ± 22.7 and 58.1 ± 19.8, <i>p</i> = 0.059). <b><i>Conclusions:</i></b> Women who underwent TOT surgery did not show increased OAB SB scores when compared to controls. Our study suggests that OAB symptoms may thus be present but overlooked during initial clinical assessment.
НАВЧАЛЬНО-БІОЛОГІЧНИЙ МУЗЕЙ КАФЕДРИ МЕДИЧНОЇ БІОЛОГІЇ – ЦІННИЙ СКАРБ І ГОРДІСТЬ УНІВЕРСИТЕТУ
Authors: Fedonyuk L. Ya. , Podobivsky S. S. , Yarema O. M. 
Published: June 2018

Мета роботи – висвітлити багатогранне значення (навчальне, наукове та виховне) навчально-біологічного музею імені І. І. Яременка кафедри медичної біології.Основна частина. Серед різноманітності наочностей одне з перших місць повинні зайняти натуральні об’єкти і їх зображення, які створюють найповніше уявлення змісту оточуючої нас живої природи. З огляду на це, певне місце в навчально-виховному процесі займають музеї.Навчально-біологічний музей імені І. І. Яременка кафедри медичної біології має багатогранне значення: навчальне, наукове та виховне. Навчальне: експонати музею відображають тематичні розділи програми з дисципліни, за допомогою яких студенти спостерігають взаємозв’язок рослинного та тваринного світу, організмів між собою i навколишнім середовищем, формують уявлення про будову багатоклітинних організмів, а також вивчають роль людини у зміні природних екосистем. Наукове: експозиції секцій музею цінні тим, що формують систему знань про закони природи, вони є базою для дослідження основ паразитизму та паразитарних інвазій у людини. Виховне: музей формує гуманне, дбайливе та бережливе ставлення до природи рідного краю, вміння естетично ставитися до всього живого, він відіграє важливу роль у формуванні екологічної свідомості студентів.Висновки. Навчально-біологічний музей є експозиційним проектом і освітнім ресурсом кафедри медичної біології, який відображає не лише історію розвитку живих організмів, але й історію створення музею природи, історію кафедри, історію вузу. Музей завжди був та залишається гордістю навчального закладу, насамперед гордістю за людей, які заклали його фундамент.
СИНДРОМ ВИГОРАННЯ – ВАЖЛИВА ПРОБЛЕМА ПІДГОТОВКИ МЕДИЧНИХ СЕСТЕР (ДОСВІД ПІВДЕННОЇ ЧЕХІЇ)
Authors: Kastnerová M. , Babinets L. S. , Borovyk I. O. , Botsyuk N. Ye. , Migenko B. O. 
Published: June 2018

Мета роботи – оцінити особливості виникнення і проявів синдрому вигорання (СВ), а також необхідність та можливості профілактики СВ. Дослідження проводили за допомогою стандартних і нестандартних опитувальників шляхом анонімного опитування медперсоналу. У ньому взяли участь медичні сестри, які працюють у лікарнях Південної Чехії (Богемії).Основна частина. За результатами загальних отриманих параметрів згідно з опитувальником Maslach Burnout Inventory ми виявили, що в 46,7 % медсестер наявний високий ступінь СВ. В області емоційного виснаження в 290 респондентів (29 %) констатовано його низький ступінь, в 310 опитаних (31 %) – помірний ступінь, а в 400 медичних сестер, що становить 40 %, – високий ступінь емоційного виснаження. За показниками деперсоналізації в 340 респондентів (34 %) виявлено низький ступінь знеособлення, в 310 (31 %) – помірний, а в 350 (35 %) – високий ступінь деперсоналізації. За показником особистої задоволеності нами зафіксовано високий ступінь редукції професійних досягнень у 650 опитаних (65 %), помірний – у 190 (19 %) і низький – у 160 (16 %). Аналіз даних, що стосувались можливостей попередження СВ, виявив, що 79 % опитаних потребують професійної допомоги у вирішенні проблеми СВ і зазначили важливість проведення профілактичних заходів для превенції СВ, 13 % не вважають СВ проблемою, а 8 % взагалі не обізнані із СВ.Висновки. Синдром вигорання у медсестер лікарень Південної Чехії (Богемії) є актуальною проблемою, наявний у 46,7 % опитаних. Встановлено, що високі ступені вигорання мають середні медичні працівники як відділень невідкладної допомоги, так і стандартних загальнотерапевтичних відділень. 79 % опитаних зазначили важливість проведення профілактичних заходів для попередження розвитку СВ, а також необхідності в консультуванні психологами для вироблення навичок самодопомоги в боротьбі зі стресом.