bluuebunny/crossref_metadata_2025_split huggingface dataset:
The longitudinal relationships between pain severity and disability versus health-related quality of life and costs among chronic low back pain patients
Authors: Mutubuki E. N. , Beljon Y. , Maas E. T. , Huygen F. J. P. M. , Ostelo R. W. J. G. , van Tulder M. W. , van Dongen J. M. 
Published: September 2019

AbstractPurposePrevious studies found higher levels of pain severity and disability to be associated with higher costs and lower health-related quality of life. However, these findings were based on cross-sectional data and little is known about the longitudinal relationships between pain severity and disability versus health-related quality of life and costs among chronic low back pain patients. This study aims to cover this knowledge gap by exploring these longitudinal relationships in a consecutive cohort.MethodsData of 6316 chronic low back pain patients were used. Measurements took place at 3, 6, 9, and 12 months. Pain severity (Numeric pain rating scale; range: 0–100), disability (Oswestry disability index; range: 0–100), health-related quality of life (EQ-5D-3L: range: 0–1), societal and healthcare costs (cost questionnaire) were measured. Using linear generalized estimating equation analyses, longitudinal relationships were explored between: (1) pain severity and health-related quality of life, (2) disability and health-related quality of life, (3) pain severity and societal costs, (4) disability and societal costs, (5) pain severity and healthcare costs, and (6) disability and healthcare costs.ResultsHigher pain and disability levels were statistically significantly related with poorer health-related quality of life (pain intensity: − 0.0041; 95% CI − 0.0043 to − 0.0039; disability: − 0.0096; 95% CI − 0.0099 to − 0.0093), higher societal costs (pain intensity: 7; 95% CI 5 to 8; disability: 23; 95% CI 20 to 27) and higher healthcare costs (pain intensity: 3; 95% CI 2 to 4; disability: 9; 95% CI 7 to 11).ConclusionPain and disability were longitudinally related to health-related quality of life, societal costs, and healthcare costs. Disability had a stronger association with all outcomes compared to pain.
Change of Direction Assessment Following Anterior Cruciate Ligament Reconstruction: A Review of Current Practice and Considerations to Enhance Practical Application
Authors: Marques Joao Beleboni , Paul Darren James , Graham-Smith Phil , Read Paul James 
Published: September 2019

AbstractChange of direction (CoD) has been indicated as a key mechanism in the occurrence of anterior cruciate ligament (ACL) injury during invasion sports. Despite these associations, assessments of knee function in athletic populations at the time of return to sport following ACL reconstruction (ACLr) have often focused on strength and single-leg hop tests, with a paucity of evidence to describe the CoD characteristics. Therefore, the aim of this narrative review was to describe the movement strategies exhibited following ACLr during CoD tasks and to critically analyze the range of tests that have been used. Specifically, we examined their ability to identify between-limb deficits and individuals who display a heightened risk of secondary injury and/or reductions in their level of pre-injury performance. MEDLINE, PubMed and SPORT Discuss databases were used and 13 articles were identified that met the inclusion criteria. Examination of the available literature indicates that current field-based practices are not representative of relevant sport demands and are unable to effectively assess knee function following ACLr. Laboratory-based studies have identified residual deficits and altered movement strategies at the time of return to sport, and this in part may be related to risk of re-injury. However, these assessments exhibit inherent limitations and are not practically viable for monitoring progress during rehabilitation. Consequently, alternative solutions that are more-aligned with the multitude of factors occurring during CoD maneuvers in chaotic sports environments are warranted to allow practitioners to ‘bridge the gap’ between the laboratory and the sports field/court. This approach may facilitate a more informed decision-making process with the end goal being, a heightened ‘return to performance’ and a lower risk of re-injury.
Expressivism and Cognitive Propositions
Authors: BROWN JAMES L. D. 
Published: September 2019

AbstractExpressivists about normative thought and discourse traditionally deny that there are nondeflationary normative propositions. However, it has recently been suggested that expressivists might avoid a number of problems by providing a theory of normative propositions compatible with expressivism. This paper explores the prospects for developing an expressivist theory of propositions within the framework of cognitive act theories of propositions. First, I argue that the only extant expressivist theory of cognitive propositions—Michael Ridge's ‘ecumenical expressivist’ theory—fails to explain identity conditions for normative propositions. Second, I argue that this failure motivates a general constraint—the ‘unity requirement’—that any expressivist theory of propositions must provide a unified nonrepresentational explanation of that in virtue of which propositional attitudes have the content that they have. Third, I argue that conceptual role accounts of content provide a promising framework in which to develop an expressivist theory of cognitive propositions.
Extreme long waves over a varying bathymetry
Authors: Herterich James G. , Dias Frédéric 
Published: September 2019

Recent modelling work has shown that abrupt bathymetric transitions can produce dramatic amplifications of long waves, under the influence of both nonlinearity and dispersion. Here, the evolution of wave packets towards a vertical wall over a varying bathymetry is investigated with a one-dimensional conformal-mapping spectral code. In this system, wave breaking, runup and reflection, wave interference and bathymetric effects are highlighted. Wave breaking is examined with respect to geometric, kinematic and energetic conditions, with consistent results. The breaking strength is characterized for spilling and plunging based on initial wave period and amplitude. Non-breaking waves are amplified by reflection, interference and the bathymetry leading to large runups. In a typical example inspired by a real-world bathymetry, the maximum runup amplification approaches a factor of 12 – large enough for a 3 m amplitude wave to overtop a 30 m cliff.
Free Time Is Not Meant to Be Wasted: Educational, Political, and Taboo Leisure Activities among the Soviet Buryats of Eastern Siberia
Authors: Chakars Melissa 
Published: September 2019

AbstractThis article details how an increasingly educated and urban Buryat population became both the creators and consumers of new leisure activities in the late Soviet period. It argues that central and local authorities believed that leisure activities could help them to impress upon the Buryats that there were great benefits to living in the Soviet Union and to adopting a more pan-Soviet identity within the brotherhood of nations. They also presumed that leisure activities could aid in the building of a culture that was Buryat, Soviet, and more modern. This article examines why authorities assigned great importance to leisure and how they used and created cultural-educational institutions and mass media content to implement, direct, and promote cultural development. It analyzes various institutions such as museums, clubs, and theaters, as well as the production and consumption of local newspapers and television and radio programming that promoted educational leisure activities. In addition, it explores authorities’ concerns about the rise, especially among youth, of more taboo leisure activities that deviated from the official ones that they encouraged.
“Antibureaucratism” as a Yugoslav Phenomenon: The View from Northwest Croatia
Authors: Archer Rory 
Published: September 2019

AbstractMost studies of the antibureaucratic revolution have focused on political elites and activists in Serbia, Montenegro, and the autonomous provinces of Vojvodina and Kosovo. Recent scholarship has focused on individual participants, often workers, and takes their agency seriously. Building upon such research, this article explores the antibureaucratic revolution as a particular manifestation of a larger sociocultural process, constitutive of long-term structural changes across the whole of Yugoslavia. An analysis of workplace documents and local newspapers in northwest Croatia demonstrates that antibureaucratic sentiment was not the prerogative of Serbian and Montenegrins but of Yugoslav citizens more generally. Yugoslavs were conditioned by the party-state to be critical of bureaucracy. Workers began to admonish the expansion of administrative positions, which they blamed for their falling living standards. Despite decentralizing and autarkic tendencies in political and economic life in late socialist Yugoslavia, working class discontents (and representations of it) remained remarkably similar across republican boundaries. In Rijeka and its environs, a shift does not occur until in mid-1988. Condemnations of nationalism become more urgent and a skepticism toward the mass protests occurring in Serbia is palpable from this point onward.
Cauchy problem and periodic homogenization for nonlocal Hamilton–Jacobi equations with coercive gradient terms
Authors: Bardi Martino , Cesaroni Annalisa , Topp Erwin 
Published: September 2019

AbstractThis paper deals with the periodic homogenization of nonlocal parabolic Hamilton–Jacobi equations with superlinear growth in the gradient terms. We show that the problem presents different features depending on the order of the nonlocal operator, giving rise to three different cell problems and effective operators. To prove the locally uniform convergence to the unique solution of the Cauchy problem for the effective equation we need a new comparison principle among viscosity semi-solutions of integrodifferential equations that can be of independent interest.
Existence of solution for quasilinear equations involving local conditions
Authors: Cerda Patricio , Iturriaga Leonelo 
Published: September 2019

AbstractIn this paper, we study the existence of weak solutions of the quasilinear equation
\begin{cases} -{\rm div} (a(\vert \nabla u \vert ^2)\nabla u)=\lambda f(x,u) &{\rm in} \ \Omega,\\ u=0 &{\rm on} \ \partial\Omega, \end{cases}where a : ℝ → [0, ∞) is C1 and a nonincreasing continuous function near the origin, the nonlinear term f : Ω × ℝ → ℝ is a Carathéodory function verifying certain superlinear conditions only at zero, and λ is a positive parameter. The existence of the solution relies on C1-estimates and variational arguments.
From Awareness to Prognosis: Ethical Implications of Uncovering Hidden Awareness in Behaviorally Nonresponsive Patients
Authors: GRAHAM MACKENZIE , WALLACE EUGENE , DOHERTY COLIN , MCCANN ALISON , NACI LORINA 
Published: September 2019

Abstract:Long-term patient outcomes after severe brain injury are highly variable, and reliable prognostic indicators are urgently needed to guide treatment decisions. Functional neuroimaging is a highly sensitive method of uncovering covert cognition and awareness in patients with prolonged disorders of consciousness, and there has been increased interest in using it as a research tool in acutely brain injured patients. When covert awareness is detected in a research context, this may impact surrogate decisionmaking—including decisions about life-sustaining treatment—even though the prognostic value of covert consciousness is currently unknown. This paper provides guidance to clinicians and families in incorporating individual research results of unknown prognostic value into surrogate decisionmaking, focusing on three potential issues: (1) Surrogate decisionmakers may misinterpret results; (2) Results may create false hope about the prospects of recovery; (3) There may be disagreement about the meaningfulness or relevance of results, and appropriateness of continued care.
The Legacy: An Interview with Ryan Farnsworth
Authors: PALCHIK GUILLERMO 
Published: September 2019

Abstract:This paper recounts the author’s conversations with Ryan Farnsworth, a 30-year-old ALS patient who consented to be interviewed for the purpose of improving communication between physicians and patients. Under the California End of Life Option (ELOA), the patient had been prescribed medication that would allow him to end his life at a time of his choosing. He describes coping with the challenges of the illness, how he will make the decision when to take the drugs and what he hopes will be his legacy.
Disciplining sensation: the architectural thinking of Reima Pietilä
Authors: Teal Randall 
Published: September 2019

When pious critics criticized Millet for painting peasants who were carrying an offertory like a sack of potatoes, Millet responded by saying that the weight common to the two objects was more profound than their figurative distinction. As a painter, he was striving to paint the force or that weight, and not the offertory or the sack of potatoes.(Gilles Deleuze and Félix Guattari)Gilles Deleuze sought an ontology that did not, according to Todd May, ‘reduce being to the knowable’. Instead he sought a widening of thought that would allow one ‘to palpate the unknowable’. Key to this expanded field of thought is an ability to think the ‘material synthetic unity’ of ‘sensation’. Deleuze drew upon art in general, and painting in particular, to describe both the nuances of sensation and how to think sensation.
TATE’S CONJECTURE AND THE TATE–SHAFAREVICH GROUP OVER GLOBAL FUNCTION FIELDS
Authors: Geisser Thomas H. 
Published: September 2019

AbstractLet ${\mathcal{X}}$ be a regular variety, flat and proper over a complete regular curve over a finite field such that the generic fiber $X$ is smooth and geometrically connected. We prove that the Brauer group of ${\mathcal{X}}$ is finite if and only Tate’s conjecture for divisors on $X$ holds and the Tate–Shafarevich group of the Albanese variety of $X$ is finite, generalizing a theorem of Artin and Grothendieck for surfaces to arbitrary relative dimension. We also give a formula relating the orders of the group under the assumption that they are finite, generalizing the known formula for a surface.
Comparing legal styles
Authors: Valcke Catherine 
Published: September 2019

AbstractThe question of legal ‘style’ is a central one in comparative law, as mainstream comparative law tends to downplay its importance. The kinds of comparative law scholarship that have attracted most attention in the last decades – the ‘harmonisation projects’ and the ‘legal origins’ literature (perhaps also the ‘legal formant’ literature) – indeed adopt a functionalistic approach to legal systems, whereby only theoutcomeof judicial decisions (and the factors causally feeding into them) matters – that is, theirstyledoes not. This narrow perspective has led to arguments in favour of harmonisation of law worldwide – the thesis according to which law everywhere does and should converge so as to facilitate transnational commerce and globalisation more generally. I propose to argue that legal style matters, as law is about much more than just resolving disputes. Specifically, it is also, and most importantly, a collective statement of identity. To illustrate, I plan on analysing some of the most striking stylistic differences between French and English law, and outline the different such statements emerging from them.
Conceptualising ‘style’ in legal scholarship: the curious case of Zweigert's ‘style doctrine’
Authors: Cserne Péter 
Published: September 2019

AbstractThrough a close reading of Konrad Zweigert's 1961 essay and related writings, the paper discusses his use of the term ‘style’ in the classification of legal families, making three arguments. First, Zweigert's use of style is methodologically naive. He uses style as a cluster concept, grouping an eclectic mix of features characteristic for the history, language, techniques, doctrines and values of national laws. His explicit sources seem to have provided associative and superficial inspiration rather than a theoretical basis for this terminological move. Second, Zweigert's methodology could have been improved by using more rigorous style concepts – and he seems to have been aware of the necessary theoretical resources. Third, such a commitment to a humanistic and cultural approach to comparative law is not easily reconciled with the blunt functionalism of Zweigert's programmatic methodological statements. His style doctrine is only compatible with a weak version of functionalism as a ‘methodological metaphor’: the version he actually espoused.
Forecasting age distribution of death counts: an application to annuity pricing
Authors: Shang Han Lin , Haberman Steven 
Published: September 2019

AbstractWe consider a compositional data analysis approach to forecasting the age distribution of death counts. Using the age-specific period life-table death counts in Australia obtained from the Human Mortality Database, the compositional data analysis approach produces more accurate 1- to 20-step-ahead point and interval forecasts than Lee–Carter method, Hyndman–Ullah method and two naïve random walk methods. The improved forecast accuracy of period life-table death counts is of great interest to demographers for estimating survival probabilities and life expectancy, and to actuaries for determining temporary annuity prices for various ages and maturities. Although we focus on temporary annuity prices, we consider long-term contracts that make the annuity almost lifetime, in particular when the age at entry is sufficiently high.
SUBSTITUTION IN RELEVANT LOGICS
Authors: ØGAARD TORE FJETLAND 
Published: September 2019

AbstractThis essay discusses rules and semantic clauses relating to Substitution—Leibniz’s law in the conjunctive-implicational form $s\dot{ = }t \wedge A\left( s \right) \to A\left( t \right)$—as these are put forward in Priest’s books In Contradiction and An Introduction to Non-Classical Logic: From If to Is. The stated rules and clauses are shown to be too weak in some cases and too strong in others. New ones are presented and shown to be correct. Justification for the various rules is probed and it is argued that Substitution ought to fail.
Sovereignty over natural resources – A normative reinterpretation
Authors: GÜMPLOVÁ PETRA 
Published: September 2019

Abstract:This article provides a normative account of sovereign rights to natural resources on the basis of moral principles which underlie its international legal structure – the right to self-determination and human rights. The first part locates the emergence of the system of sovereign rights to natural resources in the process of the decolonisation and justifies it as a correction of historical injustice of violent appropriation of natural resources. The second part identifies the key moral component and justificatory principle of the system of sovereign rights to natural resources – the right to self-determination. I outline a justice-based interpretation of the right to self-determination and show why rights to natural resources are its corollary. The last part connects rights to self-determination and rights to natural resources to human rights and shows how human rights define the permissible scope of rights to natural resources in two dimensions – the dimension of political legitimacy of the exercise of resource rights and the dimension of the distribution of resource benefits.
Single-photon avalanche diode imagers in biophotonics: review and outlook
Authors: Bruschini Claudio , Homulle Harald , Antolovic Ivan Michel , Burri Samuel , Charbon Edoardo 
Published: September 2019

AbstractSingle-photon avalanche diode (SPAD) arrays are solid-state detectors that offer imaging capabilities at the level of individual photons, with unparalleled photon counting and time-resolved performance. This fascinating technology has progressed at a very fast pace in the past 15 years, since its inception in standard CMOS technology in 2003. A host of architectures have been investigated, ranging from simpler implementations, based solely on off-chip data processing, to progressively “smarter” sensors including on-chip, or even pixel level, time-stamping and processing capabilities. As the technology has matured, a range of biophotonics applications have been explored, including (endoscopic) FLIM, (multibeam multiphoton) FLIM-FRET, SPIM-FCS, super-resolution microscopy, time-resolved Raman spectroscopy, NIROT and PET. We will review some representative sensors and their corresponding applications, including the most relevant challenges faced by chip designers and end-users. Finally, we will provide an outlook on the future of this fascinating technology.
TCR–pMHC bond conformation controls TCR ligand discrimination
Authors: Sasmal Dibyendu K. , Feng Wei , Roy Sobhan , Leung Peter , He Yanran , Cai Chufan , Cao Guoshuai , Lian Huada , Qin Jian , Hui Enfu , Schreiber Hans , Adams Erin J. , Huang Jun 
Published: September 2019

Abstract
A major unanswered question is how a TCR discriminates between foreign and self-peptides presented on the APC surface. Here, we used in situ fluorescence resonance energy transfer (FRET) to measure the distances of single TCR–pMHC bonds and the conformations of individual TCR–CD3ζ receptors at the membranes of live primary T cells. We found that a TCR discriminates between closely related peptides by forming single TCR–pMHC bonds with different conformations, and the most potent pMHC forms the shortest bond. The bond conformation is an intrinsic property that is independent of the binding affinity and kinetics, TCR microcluster formation, and CD4 binding. The bond conformation dictates the degree of CD3ζ dissociation from the inner leaflet of the plasma membrane via a positive calcium signaling feedback loop to precisely control the accessibility of CD3ζ ITAMs for phosphorylation. Our data revealed the mechanism by which a TCR deciphers the structural differences among peptides via the TCR–pMHC bond conformation.
Repeated species radiations in the recent evolution of the key marine phytoplankton lineage Gephyrocapsa
Authors: Bendif El Mahdi , Nevado Bruno , Wong Edgar L. Y. , Hagino Kyoko , Probert Ian , Young Jeremy R. , Rickaby Rosalind E. M. , Filatov Dmitry A. 
Published: September 2019

AbstractPhytoplankton account for nearly half of global primary productivity and strongly affect the global carbon cycle, yet little is known about the forces that drive the evolution of these keystone microscopic organisms. Here we combine morphometric data from the fossil record of the ubiquitous coccolithophore genusGephyrocapsawith genomic analyses of extant species to assess the genetic processes underlying Pleistocene palaeontological patterns. We demonstrate that all modern diversity inGephyrocapsa(includingEmiliania huxleyi) originated in a rapid species radiation during the last 0.6 Ma, coincident with the latest of the three pulses ofGephyrocapsadiversification and extinction documented in the fossil record. Our evolutionary genetic analyses indicate that new species in this genus have formed in sympatry or parapatry, with occasional hybridisation between species. This sheds light on the mode of speciation during evolutionary radiation of marine phytoplankton and provides a model of how new plankton species form.