bluuebunny/crossref_metadata_2025_split huggingface dataset:
Measuring depression severity in global mental health: comparing the PHQ-9 and the BDI-II
Authors: Weobong Benedict , Weiss Helen A. , Cameron Isobel M. , Kung Simon , Patel Vikram , Hollon Steven D. 
Published: December 2018

Background: We recently completed a randomised controlled trial in Goa India in which we observed a pattern of discordance with our two primary outcome measures; the Beck Depression Inventory (BDI-II) classified patients as moderately severe at the end of treatment, whilst the Patient Health Questionnaire (PHQ-9) classified these same patients as being only mildly depressed. The aim of this study is to explore whether the disparity between these two measures is seen in other settings. Method: The relationship between BDI-II and PHQ-9 scores was compared between the Indian trial and two other studies (from United Kingdom and United States) that administered both measures to patients. Linear regression was used to quantify the non-concordance between the two measures across studies. Patients were classified by severity category on the BDI-II and PHQ-9, respectively, and relationship assessed using chi-square test. We further quantified the proportion assigned a higher category on the BDI-II than the PHQ-9 and assessed the difference in prevalence between studies using a test of proportions. Results: Correlations between PHQ-9 and BDI-II were high and similar across studies (India: r=0.79; UK: r=0.87; US: r=0.77). Regression coefficients were similar across studies, but the predicted BDI-II mean score was significantly higher in the India study (24.3) compared to the US (20.5) or UK (20.8) studies. India participants had poorer outcomes on the BDI-II than the PHQ-9 and this difference was significant relative to both the UK (prevalence difference (PD): -15.9%; p<0.0001) and US studies (PD: -15.8%; p<0.0001). Conclusions: The BDI-II and PHQ-9 measures are highly correlated, but the BDI-II tends to assign high severity scores in an Indian sample compared to UK/US samples. Where it is necessary to read items to patients, it seems likely that the PHQ-9 is a more accurate measure given that the BDI-II is longer and more complex.
Immunotherapy Using Chimeric Antigen Receptor-Engineered T Cells: A Novel Cellular Therapy with Important Implications for the Clinical Laboratory
Authors: Thibodeaux Suzanne R , Milone Michael C 
Published: December 2018

Abstract

BACKGROUND
We have entered a new era of cancer therapy, with a number of immune-based therapies already used clinically as a standard of care. Adoptive cellular immunotherapy using T cells genetically modified with chimeric antigen receptors (CAR-T cells) represents a novel therapeutic approach. CAR-T cells have produced clinical responses in B-cell malignancies that are otherwise refractory to conventional therapies. Two CAR-T cell therapies obtained regulatory approval in 2017, with many more of these therapies under clinical development.

CONTENT
This review focuses on the current state of adoptive cellular immunotherapy, specifically CAR-T cells, in the clinic and how this therapy differs from traditional small molecule and biologic therapies. Areas in which the clinical laboratory is affected by these novel therapies are discussed. Opportunities for the clinical laboratory to help guide these therapies are also highlighted.

SUMMARY
The clinical laboratory will play an integral role in the care of patients undergoing adoptive cellular therapy with engineered T cells. There are many ways that this new therapeutic approach affects the clinical laboratory, and the clinical laboratory will likely play a critical role in managing patients that are treated with CAR-T cell therapy.
Drivers Of Innovation Without Formal R&D: Selected cases of Indonesian firms
Authors: Aminullah Erman , Fizzanty Trina , B Soesanto Qinan Maulana 
Published: December 2018

<p>The objective of this study is to have deep understanding on why and how firms engaging in innovation without formal R&amp;D. Three cases of firms in machinery and food processing sectors were studied. The cross cases analysis found that types and sources of innovation vary according to business areas, technology field, and technological capability level of each firms. Firms innovate without formal R&amp;D through it’s particular ways, and it is driven by firm’s specific resources namely management vision and leadership, integrated business system, and entrepreneurship and networking. The conceptual contribution of this study is an enrichment to “learning by using” with a new variant the so called “mastering from using”. Nevertheless, innovation without formal R&amp;D is deficient in absorptive capacity (AC), it implies that non-R&amp;D and informal R&amp;D firms should invest in R&amp;D to develop AC and increase technology adoption. Goverment policy by using R&amp;D financing support and tax incentives should be directed at the innovative low-tech (LT) as well as low and medium-tech (LMT) industries, which will have produced higher results through innovation with informal and/or non R&amp;D actvities. <strong></strong></p><p class="Default">Keywords: <em>innovation drivers, innovation types, innovation sources, non-R&amp;D, informal R&amp;D</em></p>
Knowledge Accumulation-based Entrepreneurship (KABE) in the Creative Industry: A Case Study of Woodwork Firms in Indonesia
Authors: Kardoyo Hadi , Handoyo Setiowiji , Asmara Anugerah Yuka 
Published: December 2018

This article describes the activities of knowledge-intensive entrepreneurship (KIE) in four wood craft manufacturers, namely Radio Magno, Stranough Guitar Technologi, Secco Guitar, and Matoa Watch. The four wood craft manufacturers represent KIE activities in the wood craft industry in Indonesia. The products of the four wood craft manufacturers are able to compete and have market share for both domestic and foreign markets. This article shows some lessons from KIE: 1) Educational background, knowledge, and experience play a significant role in supporting KIE activities, 2) Knowledge base and learning activities support the ability of four creative wood craft manufactures in enhancing innovation and product development, 3) The idea, product concept, and innovation become an important aspect in supporting the ability of the four wood craft manufacturers in the strategy of entering the market and creating market segment for the products, 4) The four creative wood craft manufacturers are able to perform a combination of complementary aspects of KIE (market, technological and institutional opportunities), 5) Ecosystems and cultural aspects are considered as important aspect in supporting the growth of creative industries.
MOLECULAR COMPLEXES OF IVY TRITERPENE GLYCOSIDES WITH CHOLESTEROL
Authors: Яковишин (Yakovishin) Леонид (Leonid) Александрович (Aleksandrovich) , Гришковец (Grishkovets) Владимир (Vladimir) Иванович (Ivanovich) 
Published: December 2018

Molecular complexes of cholesterol with dominant triterpene saponins from members of the ivy genus Hedera L. (Araliaceae Juss.) – monodesmosidic glycoside α-hederin (hederagenin 3-O-α-L-rhamnopyranosyl-(1→2)-O-α-L-arabinopyranoside) and bisdesmosidic glycoside hederasaponin C (hederagenin 3-O-α-L-rhamnopyranosyl-(1→2)-O-α-L-arabinopyranosyl-28-О-α-L-rhamnopyranosyl-(1→4)-О-β-D-glucopyranosyl-(1→6)-О-β-D-glucopyranoside) as well as with minor monodesmosidic glycoside hederoside F (hederagenin 3-О-β-D-glucopyranosyl-(1→2)-О-β-D-glucopyranoside) have been prepared. The complexation has been investigated by methods of isomolar series in the spectrophotometric version and FT-IR spectroscopy with a universal optical attenuated total reflection (ATR) accessory. It was shown that a-hederin, hederasaponin C and hederoside F form a 1 : 1 complexes with cholesterol, having a stability constants (5.6±0.1)×104, (4.7±0.1)×104 and (6.0±0.6)×104 M–1 respectively (in 70% aqueous ethanol et 25 °С). The constants are calculated on the basis of isomolar curves. The complexes of cholesterol with ivy monodesmosidic glycosides are more stable. Intermolecular interaction in the complexes is carried out by hydrogen bonds formation of type –С=О···Н–О– (for monodesmosidic glycosides) and –(Н)О···Н–О– (for bisdesmosidic glycoside). Hydrophobic contacts of the aglycone part of glycosides (hederagenin) with a lipophilic cholesterol molecule are possible. As a result, changes in some frequencies of the absorption bands of CH bonds are observed, which was established by IR spectroscopy.
OBTAINING PLANT MATERIALS SIBERIAN IRIS (IRIS SIBIRICA L.) BY METHODS OF BIOTECHNOLOGY
Authors: Тихомирова (Tikhomirova) Людмила (Lyudmila) Ивановна (Ivanovna) , Базарнова (Bazarnova) Наталья (Natal'ya) Григорьевна (Grigor'yevna) , Ильичева (Ilicheva) Татьяна (Tat'yana) Николаевна (Nikolayevna) , Мартиросян (Martirosian) Юрий (Yuriy) Цатурович (Tsaturovich) , Афанасенкова (Afanasenkova) Ирина (Irina) Владимировна (Vladimirovna) 
Published: December 2018

Methods of biotechnology allow to obtain high-quality medicinal plant raw materials in a short time, in large quantities without destroying natural reserves. Biotechnological approaches such as aeroponic technologies have the potential for large-scale cultivation of iris plants and production of secondary metabolites. Microclonal reproduction makes it possible to obtain a healthy planting material in the required amount, regardless of the time of year. The combination of these two technological approaches will allow to develop biotechnology of year-round production of medicinal plant raw materials of Siberian iris.
The study determined the content of 6-benzylaminopurine on the stage actually micropropagation for the formation of the greatest number of adventitious shoots of optimal length. The required content of BAP in the nutrient medium for I. sibirica was 2.5–5.0 µM. The introduction of cytokinins in the nutrient medium together with auxins, L-glutamine and adenine sulfate 100 mg/l, as well as the alternation of low and high concentrations of cytokinin enhanced the regenerative effect of BAP. With year-round cultivation of regenerative plants in aeroponic conditions, the amount of biomass of plant raw materials I. sibirica for this method was about 31.2 kg / m2 of crude weight in one year.
It is established that intact plants and regenerative plants I. sibirica, obtained on the basis of the developed biotechnology, had identical group composition of biologically active substances. It is revealed that the sum of flavonoids in the leaves of hydroponic iris plants exceeded the content in the leaves of intact plants by 3 times, and the content of essential oil in regenerate plants and hydroponic leaves of the Sterch variety but higher by 26% compared with the leaves of intact plants.
Aqueous and alcoholic extracts of I. sibirica showed antiviral activity against herpes virus. With low toxicity, both intact plants and regenerative plants had a relatively high selectivity index.
PLANT POLYSACCHARIDE XYLOGLUCAN AND ENZYMES THAT HYDROLIZE IT (REVIEW)
Authors: Завьялов (Zavyalov) Артем (Artem) Валерьевич (Valer'yevich) , Рыков (Rykov) Сергей (Sergey) Викторович (Viktorovich) , Лунина (Lunina) Наталия (Nataliya) Александровна (Aleksandrovna) , Сушкова (Sushkova) Валентина (Valentina) Ивановна (Ivanovna) , Яроцкий (Yarotsky) Сергей (Sergey) Викторович (Viktorovich) , Березина (Berezina) Оксана (Oksana) Валентиновна (Valentinovna) 
Published: December 2018

Various types of plant raw material are widely used in the pulp and paper, textile, food, agricultural industries, and pharmacology. One of the problems of utilizing the complex plant biomass is the weak knowledge of its hemicellulose content and the lack of effective enzymes for hydrolysis of hemicelluloses.
Xyloglucan is the major structural and storage polysaccharide in all dicots and many monocots. It has a branched architecture with a backbone constructed of β-1,4-connected cellotetraose units decorated with short side chains composed of xylose, galactose, arabinose, fucose and some other residues. Side chain composition and alternation order are specie-specific and can change during cell growth resulting in variety of xyloglucan structural types. In general, xyloglucan structure depends on taxonomic position of the plant. Structural features of xyloglucans belonging to different taxonomic groups are discussed in the evolutionary aspect.
Xyloglucan hydrolysis is a necessary condition during conversion of plant biomass into high added value products. Variety of xyloglucan structural types complicates selection of enzymes for its hydrolysis. Xyloglucanase-containing multienzyme complexes can be used for efficient decomposition of plant biomass polysaccharides into fermentable sugars for biotechnology, and for improvement of the feed quality. Investigation of xyloglucanases is necessary for the development of methods for protecting plants from pathogenic microorganisms which use these enzymes for invasion into plant tissue.
The article reviewed structural features of xyloglucans from different taxonomic groups in the evolutionary aspect. Selection of xyloglucanases for efficient hydrolysis of complex plant biomass is discussed.
DROUGHT INFLUENCE ON THE CONTENT AND COMPOSITION OF ALKALOIDS FROM SEEDS OF THE CHAMAECYTISUS RUTHENICUS (FISCH. EX WOLOSZCZ.) KLASKOVA, GROWING AT THE MOUNTAIN-FORESTS ZONE OF SOUTHERN URALS
Authors: Цыпышева (Tsypysheva) Инна (Inna) Петровна (Petrovna) , Галкин (Galkin) Евгений (Evgeniy) Григорьевич (Grigor'yevich) , Петрова (Petrova) Полина (Polina) Радиковна (Radikovna) , Ковальская (Koval’skaya) Алена (Alena) Витальевна (Vital'yevna) , Федоров (Fedorov) Николай (Nikolay) Иванович (Ivanovich) 
Published: December 2018

Quinolizidine alkaloid content of the Chamaecytisus ruthenicus (Fabaceae) seeds, collected in the period of drought in 2010 and in 2011 (last was normal in the number of precipitation), was determined by the chromato-mass-spectrometry method. Total sums of alkaloids from the seeds of Chamaecytisus ruthenicus were isolated in two stages. The first stage included preliminary "degreasing" of crushed seeds with hexane. Then resulting hexane extract was washed with aqueous solution of 3% hydrochloric acid, and acidic layer was treated by anhydrous Na2CO3 until pH 9. Alkaloids (in the form of bases) were extracted with chloroform. In parallel, the seeds are previously washed with hexane were thoroughly extracted with an acetone-water mixture (1 : 9), and then resulting water-acetone extract has been treated in accordance with the traditional method. Alkaloids obtained from hexane extract and fatless seeds were combined, concentrated and analyzed by chromato-mass spectrometry method. Individual alkaloids were identified by their full mass spectra using d-lupanine as a standard. On the base on obtained results, it was found that in drought conditions of 2010 the content of alkaloids in seeds of the Russian Broom (Ch. Ruthenicus) is significantly lower than in 2011, typical for its weather conditions (0.81% vs. 3.2%). However, the composition of alkaloids in the seeds of the Ch. ruthenicus, collected during the drought period, was more various: sparteine, methylcytisine, 17-oxosparteine, sophocarpine, d-lupanine, isoquinoline alkaloid salsolidine and pyridine alkaloid ammodendrine were found in these seeds. Only four quinolizidine alkaloids – sparteine, d-lupanine, 17-oxosparteine and sophocarpine were isolated from the seeds of Ch. ruthenicus 2011.
TOTAL FLAVONOIDS IN CRATAEGUS «FLOWERS WITH LEAVES» RAW MATERIAL OF RUSSIAN FLORA
Authors: Сагарадзе (Sagaradze) Валентина (Valentina) Андреевна (Andreyevna) , Бабаева (Babaeva) Елена (Elena) Юрьевна (Yur'yevna) , Уфимов (Ufimov) Роман (Roman) Александрович (Aleksandrovich) , Загурская (Zagurskaya) Юлия (Yuliya) Васильевна (Vasil'yevna) , Трусов (Trusov) Николай (Nikolay) Александрович (Aleksandrovich) , Коротких (Korotkikh) Ирина (Irina) Николаевна (Nikolaevna) , Маркин (Markin) Вадим (Vadim) Иванович (Ivanovich) , Пещанская (Peschanskaya) Екатерина (Yekaterina) Владимировна (Vladimirovna) , Можаева (Mozhaeva) Галина (Galina) Федоровна (Fedorovna) , Каленикова (Kalenikova) Елена (Elena) Игоревна (Igorevna) 
Published: December 2018

The total flavonoid content of various species of Crataegus novel raw material– «flowers with leaves» was conducted to a comparative study in order to identify the possibility of co-harvesting material from different species. 27 samples of 6 pharmacopoeial and 7 nonpharmacopoeial Crataegus species obtained from the Biological Collections of VILAR, Tsitsin Main Botanical Garden RAS, Kuzbass, Penza and Stavropol Botanical Gardens, Altai Territory, Voronezh region, Kemerovo and Moscow harvested in Russian Federation were analyzed.
Spectrophotometric assay was based on aluminium complex formation was used for determination of total flavonoid expressed as hyperoside. The fractional composition of the raw material (percentage of leaves and stems) and its influence on the content of flavonoids was studied.
The total flavonoids expressed as hyperoside of the raw material "flowers with leaves" of pharmacopoeial Crataegus species ranged from 1.40±0.05% (C. chlorocarpa) to 2.20±0.11% (C. monogyna), nonpharmacopeal species – from 1.21±0.11% (C. maximowiczii) to 2.21±0.09% (C. ambigua). The average quantity was 1.65%. The total flavonoid values of non-pharmacopoeial species raw material were comparable with pharmacopoeial species thus it allows to consider them promising for further study and use of their parts for medical purpose.
DETERMINATION of QUANTITATIVE CONTENT of EXTRACTIVE SUBSTANCES FROM the WOOD, ROOTS AND BARK of CONIFEROUS SPECIES in SIBERIA: LARCH (LARIX SIBIRICA L.), Scotch PINE (PINUS SYLVESTRIS L.), FIR (ABIES SIBIRICA L.), SPRUCE (PICEA OBOVATA L.) AND CEDAR (PINUS SIBIRICA DU TOUR.)
Authors: Остроухова (Ostroukhova) Людмила (Lyudmila) Андреевна (Andreyevna) , Федорова (Fedorova) Татьяна (Tat'yana) Евгеньевна (Evgen'evna) , Онучина (Onuchina) Нина (Nina) Аркадьевна (Arkad'yevna) , Левчук (Levchuk) Алексей (Aleksey) Александрович (Aleksandrovich) , Бабкин (Babkin) Василий (Vasiliy) Анатольевич (Anatol'yevich) 
Published: December 2018

The study of the quantitative content of extractive substances from various tree organs (wood, roots, bark) of coniferous Siberian specieswas conducted. The larch (Larix sibirica L.), pines (Pinus sylvestris L.), fir (Abies sibirica L.), spruce (Picea obovata L.) and cedar (Pinus sibirica Du Tour) were investigated.
Samples of coniferous tissues were selected in the Lake Baikal area in September-October 2015. Extractive substances were extracted from the ground raw material by extraction with ethyl acetate at the boiling point of the solvent for 4 hours. The resinous substances were extracted from the obtained ethyl acetate extracts by hexane by the infusion method for 2 days. The raw material samples, after extraction with ethyl acetate, were dried from solvent residues, then water-soluble substances were extracted by extraction with distilled water at 90 °C for 4 hours [1].
It is established the bark of the investigated coniferous species is most rich in extractive substances. It can contain up to 15% of the mass of absolutely dry matter (a.d.m.) of compounds soluble in ethyl acetate (for example, fir bark). The yield of extractive substances from coniferous wood is comparable with their content in the roots and ranges from 2 to 6% of the a.d.m.
The greatest amount of resinous substances contain in wood of cedar and pine. This is more than 3% of a.d.m. The highest yield of water-soluble substances was from larch wood (18% of a.d.m.) and fir bark (10% of a.d.m.).
A generalization and systematization of data on the chemical composition of phenolic extractive compounds of various coniferous tissues was carried out. It is shown that all the species under study contain a variety of biologically valuable polyphenols and have good potential for pharmacology, agriculture and forestry.
Seyyid Muhammed Ali Rızâ’nın Mevlid’i
Authors: KAYALIK ŞAHİN Duygu 
Published: December 2018

Sözlüklerde, ‚doğum yeri‛ ve ‚doğum zamanı‛ anlamlarına gelen mevlid kelimesi, ıstılahîmânâda Hz. Muhammed’in doğduğu zamanı ve mekânı ifade etmektedir. Edebî bir terim olarak mevlid, Hz. Muhammed’in doğumunu, doğumunda meydana gelen mucizeleri, hayatını, fizikî-ahlakî özelliklerini ve vefatını anlatan, genellikle manzûm olarak kaleme alınan eserlerdir. Önceleri siyer türünün bir bölümü olarak yazılan mevlid, zamanla müstakil bir tür mahiyeti kazanmıştır. Özellikle Süleymân Çelebî’nin Mevlid’inin çok sevilmesiyle birlikte, çok sayıda mevlid kaleme alınmıştır. Yazılan bu mevlidlerden biri de çalışmamızda ele aldığımız 20.yy şairlerinden Seyyid Muhammed Ali Rıza’ya aittir. Bu Mevlid’in, bilinen yegâne yazma nüshası Süleymaniye Kütüphanesi, Yazma Bağışlar Koleksiyonu 7161/1 numarada kayıtlıdır. Çalışmamızda, mevlid türüne dair bazı bilgiler verildikten sonra ‚Mevlûd-i Seydî‛ başlıklı mevlid metni, şekil bakımından incelenmiş muhteva bakımından değerlendirilmiştir. Müellif, eldeki bilgilerle tanıtılmış, son olarak mezkûr nüshanın transkripsiyonlu metni hazırlanmıştır.
Religion, Radicalism and National Character: In Perspective of South Sulawesi Local Wisdom
Authors: Mahmuddin Mahmuddin 
Published: December 2018

It is widely believed that Indonesia is encountering an issue of disharmony due to a number of horizontal conflicts which are based on ethnics, religions, and races. In addition, there are many social issues also happen in recent years that stimulate the conflicts. For example, the rampant of drugs users across the country and the increase of significant number of terrorists in many regions in Indonesia. The writer believes that one of the main reasons of these conflicts is lacking of understanding nation charachter as well as local wisdoms that owned by certain community. In the mean time, Indonesia as country is rich of characters that can unite community under the flag of nation and diminish conflicts among them. In the context of South Sulawesi region, there are, at least, three different characters that can decrease the emergence of radicalism. Firstly, respect to the difference. Secondly, they are open-minded. Thirdly, maintaining tradition of ashame (siri) as a local genius. These characters are social capitals of South Sulawesi communities in tackling radicalism understanding. The writer come to conclude that if every single ethnics in Indonesia make their local genius as their philosophy in daily life, the radicalism movement might be tackled across the country.[Dipercaya secara luas bahwa Indonesia menghadapi masalah ketidakharmonisan karena sejumlah konflik horizontal yang didasarkan pada etnis, agama, dan ras. Selain itu, ada banyak masalah sosial juga terjadi dalam beberapa tahun terakhir yang merangsang konflik. Misalnya, merajalela pengguna narkoba di seluruh negeri dan meningkatnya jumlah teroris yang signifikan di banyak wilayah di Indonesia. Penulis percaya bahwa salah satu alasan utama dari konflik ini adalah kurangnya pemahaman tentang karakter bangsa dan juga kearifan lokal yang dimiliki oleh masyarakat tertentu. Sementara itu, Indonesia sebagai negara kaya akan karakter yang bisa menyatukan masyarakat di bawah bendera negara dan mengurangi konflik di antara mereka. Dalam konteks wilayah Sulawesi Selatan, setidaknya ada tiga karakter berbeda yang dapat menurunkan kemunculan radikalisme. Pertama, hargai perbedaannya. Kedua, mereka berpikiran terbuka. Ketiga, menjaga tradisi ashame (siri) sebagai jenius lokal. Karakter ini adalah ibu kota sosial masyarakat Sulawesi Selatan dalam mengatasi pemahaman radikalisme. Penulis kemudian menyimpulkan bahwa jika setiap etnis di Indonesia membuat jenius lokal mereka sebagai filosofi mereka dalam kehidupan sehari-hari, gerakan radikalisme dapat ditangani di seluruh negeri.]