bluuebunny/crossref_metadata_2025_split huggingface dataset:
“Summer is you”: Adolescents and young adults with cancer sing about their desire for summer
Authors: Signoroni Stefano , Veneroni Laura , Pagani Bagliacca Elena , Gaggiotti Paola , Silva Matteo , Casanova Michela , Chiaravalli Stefano , Clerici Carlo Alfredo , Massimino Maura , Ferrari Andrea 
Published: January 2019

AbstractCreative spirit and art are used as part of the Youth Project in Milan, a program dedicated to adolescents and young adults (AYA) with cancer. The “Summer is you” music project involved 45 patients (15–26 years old): with professional help, the patients wrote music and lyrics, sang their song, and recorded a video clip, sharing with us not only their hopes and fears, but also their romantic encounters and their urge to travel (https://youtu.be/Q5FSCMUVg0E). This project exploited the power of music to bring young people with cancer together in a novel form of support that can complement the more conventional psychological approaches.
Severity, change over time, and risk factors of anxiety in children with cancer depend on anxiety instrument used
Authors: Lazor Tanya , Pole Jason D. , De Souza Claire , Schechter Tal , Grant Ronald , Davis Hailey , Duong Nathan , Stein Eliana , Cook Sadie , Tigelaar Leonie , Sung Lillian 
Published: January 2019

AbstractObjectiveThe primary objective was to describe severity of anxiety among children and adolescents receiving chemotherapy for cancer or undergoing hematopoietic stem cell transplantation (HSCT). Secondary objectives were to describe how anxiety changes over time and determine factors associated with anxiety.MethodsParticipants were aged 8 to 18 and either receiving chemotherapy for cancer or undergoing HSCT for any indication. Respondents self‐reported three anxiety measurement instruments at chemotherapy cycle or HSCT conditioning start and 3 weeks later.ResultsThe proportion of participants with severe anxiety ranged from 10/77 (13.0%) to 22/77 (28.6%) depending on instrument used. Change over time also varied across instruments, with significant improvement observed with PedsQL (procedural) (P = 0.037) and PROMIS (P = 0.013). Factors associated with anxiety similarly varied by instrument. Older age was associated with more anxiety on the PedsQL (worry) (P = 0.036), and higher household income was associated with less anxiety on the MASC‐10 (P = 0.028).ConclusionsWhile we found that a small proportion of patients met or exceeded thresholds for severe anxiety, we also noted that severity, change over time, and predictors of anxiety varied depending on instrument used. Future research should ensure that selected instruments measure the construct of interest and describe how anxiety is conceptualized in the study.
A universal wind profile for the inversion‐capped neutral atmospheric boundary layer
Authors: Kelly Mark , Cersosimo Roberto Alessio , Berg Jacob 
Published: January 2019

Wind profiles above the atmospheric surface layer are not accurately described by classic similarity theories. Far from the surface, the underlying assumptions of such surface‐layer theories break down due to the stronger influence of buoyancy forces induced by the temperature inversion that caps the atmospheric boundary layer (ABL), as well as the Coriolis force. This paper examines the influence of these forces on the mean flow and presents a new similarity theory to predict mean wind profiles in and above the surface layer for an ABL with zero surface heat flux and capped by an inversion of potential temperature, that is, the conditionally neutral ABL. The analysis here is based on the results of 17 large‐eddy simulations (LES) over a flat homogeneous rough surface, which leads to and supports the new similarity theory. The development is based on two applications of the Buckingham Π theorem. A first application allows determination of the entrainment‐induced heat flux profile through the ABL and into the surface layer, which is then used within a second dimensional argument for the vertical shear of mean wind speed. We subsequently find a new dimensionless group (Π2) depending on the capping inversion strength, the Coriolis parameter, the surface stress and the ABL depth, which is correlated to the dimensionless shear (Π1) through a universal function β. Integrating the functional relation between Π1 and Π2 produces an equation for the mean wind speed profile; it effectively includes an additive “correction” to the log‐law in terms of Π2, analogous to the Monin–Obukhov profile correction function. Unlike surface‐layer similarity, the new form accounts for the influences of both the surface and the ABL top. Relative to the LES, the new profile form exhibits errors in mean wind speed below 5% for heights below 90% of the ABL depth; this is relevant for applications above the surface layer (e.g., wind energy).
Alternative mass spectrometry techniques for the validation of the fragmentation pattern of capsaicin and dihydrocapsaicin
Authors: Rosas Julieta , Martínez Joel O. , Alonso Pedro , Miranda René , Velasco Luis , Rubio‐Pérez Laura , Pérez Francisco J. 
Published: January 2019

RationaleCapsaicinoids are prevalent secondary metabolites in many natural and synthetic pharmacological compounds. To date, several soft ionization studies related to capsaicinoids have been reported; they all proposed a common fragmentation pattern based on a rearrangement of the aromatic double bonds and the fragmentation of the various positional acyl chains. However, the mechanism has never been validated by high‐resolution analyses. Consequently, in this work, a validated fragmentation mechanism of the main capsaicinoids, capsaicin (1) and dihydrocapsaicin (2), is offered.MethodsIn order to propose and validate a common electron ionization (EI) fragmentation mechanism for the target analytes, the following mass spectrometric methods were employed: collision‐induced dissociation (CID) by means of linked scans (LS), reinforcing the methodology by high‐resolution mass spectrometry (HRMS), in addition to appropriate deuterium‐labeled experiments performed using gas chromatography/mass spectrometry (GC/MS) and direct analysis in real time (DART).ResultsIn a first stage, a common EI fragmentation pattern comprising two pathways was proposed for compounds 1 and 2; then, the suggested mechanism was validated by CID‐LS together with HRMS complemented by DART‐deuterium‐labeling studies. The obtained results are indicative that the corresponding molecular ions were conveniently observed, m/z 305 and m/z 307; it is worth noting that the common base peak is in correspondence with a tropylium ion derivative (m/z 137), as a consequence of a McLafferty rearrangement. In addition to these highlighted fragments, other common ions, m/z 122 and m/z 94, and their corresponding trajectory, were confirmed using the same approach. Finally, the proposed mechanism was complementarily validated by deuterium‐labeling studies, taking into account the two exchangeable hydrogens present in the phenolic and the amidic moieties.ConclusionsA common validated EI fragmentation pattern for both capsaicin and dihydrocapsaicin was established using appropriated mass spectrometric methods together with convenient hydrogen/deuterium labeling. This study provides a new alternative to validate mechanisms of fragmentation of important natural products.
Towards the use of ion mobility mass spectrometry derived collision cross section as a screening approach for unambiguous identification of targeted pesticides in food
Authors: Goscinny Séverine , McCullagh Michael , Far Johann , De Pauw Edwin , Eppe Gauthier 
Published: January 2019

RationaleMass spectrometry (MS) is the reference method for the screening of ultra‐trace residues of pesticides in food because MS offers the required selectivity/sensitivity to gather information and enable the analyst to make informed decisions during the identification process. Here we present and discuss the use of collision cross section (CCS) values in addition to mass accuracy and retention times in a pesticide screening method that integrates all the features offered by coupling ultra‐performance liquid chromatography (UPLC) with ion mobility mass spectrometry (IMS‐MS).MethodsAll experiments were carried out using UHPLC coupled to a travelling wave ion mobility mass spectrometer equipped with an electrospray ionization (ESI) source working in positive mode. An in‐house library containing 200 pesticides was built using standard solutions and used as reference for a TWCCS calibration study. Matrix extracts were analyzed to evaluate the performance of different screening workflows based on TWCCS, mass accuracy and retention times.ResultsThe results proved that TWCCS values are very consistent, as the measured values do not differ more than 1% from the in‐house reference data library and emphasized the importance of the first low m/z mobility calibration point to guarantee full independence from instrument parameters and calibrant. The screening procedure was simplified to a single step by fully exploiting the content of ion mobility without generating any false detections, either positive or negative, from spiked samples and a previous proficiency test.ConclusionsThe screening approach proposed in this study is unconventional and based on large mass accuracy (20 ppm) and retention time windows (0.5 min) to capture, in a first step, a maximum of detected compounds. Compounds of interest are then identified by comparing measured collision cross sections with the measured reference library collision cross sections (with relative error tolerance lower than 2%).
Hydrothermal Synthesis and Luminescent Properties of Spindle‐Like NaGd(MoO4)2:Eu3+ Phosphors
Authors: Ding Yao , Meng Qingyu 
Published: January 2019

AbstractSpindle‐like NaGd(MoO4)2: Eu3+ phosphors with various Eu3+ concentrations were prepared via a hydrothermal process and characterized using X‐ray diffraction (XRD) and field emission scanning electron microscopy (FE‐SEM). The XRD results suggested that the prepared samples had a scheelite structure. The FE‐SEM images indicated that the prepared NaGd(MoO4)2: Eu3+ phosphors were spindle‐like. The influences of the ratio of sodium citrate and the rare earth cations on the product were studied. It was found that sodium citrate, as the chelating agent, could significantly influence the structure and morphology of the samples. The emission spectra, excitation spectra, fluorescence decay curves, and quantum yields of the samples were measured. The luminescent properties of the materials were studied. The results indicated that the electron–phonon coupling between the Eu3+ and the NaGd(MoO4)2 host was weak, and with the increase of the Eu3+ concentration, the Huang–Rhys factor increased. Additionally, the quantum efficiency of the Eu3+ 5D0 level was calculated, and it was found that the quantum efficiency decreased with the increase of the Eu3+ concentration.
A Practical Green Visit to the Functionalized [1,2,4]Triazolo[5,1‐b]quinazolin‐8(4H)one Scaffolds Using the Group‐Assisted Purification (GAP) Chemistry and Their Pharmacological Testing
Authors: Patel Divyang M. , Vala Ruturajsinh M. , Sharma Mayank G. , Rajani Dhanji P. , Patel Hitendra M. 
Published: January 2019

AbstractHerein, we established a straightforward synthetic route for biological relevant [1,2,4]triazolo[5,1‐b]quinazolin‐8(4H)one scaffolds using the group‐assisted purification (GAP) chemistry via one‐pot and three component reaction of 3‐Amino‐5‐methylthio‐1H‐1,2,4‐triazole (1), Aryl aldehyde(2 a–g), and 1,3‐cyclodione (3 a–b) using L‐proline and aqueous ethanol (1:1, v/v) as green catalyst and reaction media respectively. This work shows some key features such as practical low Environment factor (E‐factor) values, excellent atom economy, reaction mass efficiency, mild reaction condition, metal‐free synthesis, and no use of column chromatography. In preliminary biological screening, the compounds, 2‐(methylthio)‐9‐(4‐nitrophenyl)‐5,6,7,9‐tetrahydro‐[1,2,4]triazolo[5,1‐b]quinazolin‐8(4H)‐one (4 i) and 6,6‐dimethyl‐2‐(methylthio)‐9‐(pyridin‐4‐yl)‐5,6,7,9‐tetrahydro‐[1,2,4]triazolo[5,1‐b]quinazolin‐8(4H)‐one (4 l) were found most potent against Gram‐negative bacteria (E. coli) than the standard drugs ampicillin and chloramphenicol. Moreover, compounds 2‐(methylthio)‐9‐phenyl‐5,6,7,9‐tetrahydro‐[1,2,4]triazolo[5,1‐b]quinazolin‐8(4H)‐one (4 a) and 9‐(4‐methoxyphenyl)‐6,6‐dimethyl‐2‐(methylthio)‐5,6,7,9‐tetrahydro‐[1,2,4]triazolo[5,1‐b]quinazolin‐8(4H)‐one (4 f) exhibited excellent potency in comparison with the standard drugs ampicillin, chloramphenicol, and ciprofloxacin against Gram‐positive bacteria (S. aeruginosa and S. pneumoniae). In antifungal screening compounds, 9‐(4‐methoxyphenyl)‐2‐(methylthio)‐5,6,7,9‐tetrahydro‐[1,2,4]triazolo[5,1‐b]quinazolin‐8(4H)‐one (4 e) and 2‐(methylthio)‐9‐(4‐nitrophenyl)‐5,6,7,9‐tetrahydro‐[1,2,4]triazolo[5,1‐b]quinazolin‐8(4H)‐one (4 i) efficiently inhibited C. albicans fungi strain than that of standard drug griseofulvin. Noteworthy compounds 6,6‐dimethyl‐2‐(methylthio)‐9‐phenyl‐5,6,7,9‐tetrahydro‐[1,2,4]triazolo[5,1‐b]quinazolin‐8(4H)‐one (4 b), 9‐(4‐chlorophenyl)‐6,6‐dimethyl‐2‐(methylthio)‐5,6,7,9‐tetrahydro‐[1,2,4]triazolo[5,1‐b]quinazolin‐8(4H)‐one (4 d), and 2‐(methylthio)‐9‐(pyridin‐4‐yl)‐5,6,7,9‐tetrahydro‐[1,2,4]triazolo[5,1‐b]quinazolin‐8(4H)‐one (4 k) were exhibited better potency against M. Tuberculosis.
Developing a New qPCR‐Based System for Screening Mutation
Authors: Zhu Junjie , Zhao Yanfeng , Liu Ming , Gonzalez‐Rivas Diego , Xu Xinnan , Cai Weijing , Qi Huiwei , Dai Lei , Wang Zijian , Song Xiao , Jiang Gening , Yang Yang 
Published: January 2019

AbstractAn accurate genotyping analysis is one of the critical prerequisites for lung cancer targeted therapy. Here, a quantitative polymerase chain reaction (qPCR)‐based mutation detection system, mutation‐selected amplification‐specific system PCR (MASS‐PCR), is developed. The specific primers and probes used in MASS‐PCR exactly match with the mutant sequence that only allows mutant gene to emit the fluorescence peak. To determine the sensitivity of MASS‐PCR, 717 lung cancer specimens, 61 formalin‐fixed paraffin‐embedded (FFPE) tissues, and 656 fresh reaction tissues are collected and undergo mutation detection of lung cancer driver genes (EGFR, KRAS, BRAF, HER2, MET, ALK, and ROS1). These samples are divided into two groups. Mutations in Group I, which has 631 fresh reaction tissues, are analyzed by MASS‐PCR and the amplification refractory mutation system PCR (ARMS‐PCR). While group II samples, 25 fresh reaction tissues and 61 FFPE tissues, are screened through MASS‐PCR and next‐generation sequencing (NGS). All results are verified by direct sequencing. MASS‐PCR shows high consistency with ARMS‐PCR (kappa value > 0.733) and NGS (kappa value = 0.79) (P < 0.001). For the samples with inconsistent MASS‐PCR and ARMS‐PCR results, DS results more likely support the MASS‐PCR results. These data suggest that MASS‐PCR is a convenient, accurate, and economical method for the detection of lung cancer driver gene mutations in clinical practice.
Ranking enterprise application integration platforms from a performance perspective: An experience report
Authors: Freire Daniela L. , Frantz Rafael Z. , Roos‐Frantz Fabricia 
Published: January 2019

SummaryEnterprises turn to their software applications to support their business processes. Over time, it is common for a company to end up with a wide range of applications, which are usually developed in‐house by its information technology department or purchased from third‐party specialized software companies. The result is a heterogeneous software ecosystem with applications developed in different technologies and frequently using different data models, which brings challenges when two or more applications have to collaborate to support a business process. Integration platforms are specialized software tools that help design, implement, run, and monitor integration solutions that orchestrate a set of applications. The run‐time system is the component of integration platforms responsible for running integration solutions, which makes its performance a critically important issue. In this paper, we report our experience in evaluating and comparing four well‐known open‐source integration platforms in the context of a research project where performance was a central requirement to choose an integration platform. The evaluation was conducted using a decision‐making methodology to build a ranking of candidate platforms by means of subjective and objective criteria. The subjective evaluation takes into account expert preferences and compares integration platforms using the analytic hierarchy process, which has been used in many applications related with decision‐making. The objective evaluation is build on top of properties distributed on three dimensions, namely, message processing, hotspot detection, and fairness execution, which compose the research methodology we used. The evaluated platforms were ranked to identify the one with the best performance.
Dynamic behaviour of unbraced steel frames resting on soft ground
Authors: Far Harry 
Published: January 2019

AbstractMany recent earthquakes clearly illustrate the importance of local ground properties for the dynamic response of structures. The dynamic response of an engineering structure is influenced by the medium on which it is founded. On solid rock, a fixed‐base structural response occurs which can be evaluated by subjecting the foundation to the free‐field ground motion occurring in the absence of the structure. However, on deformable ground, a feedback loop exists. In other words, when a feedback loop exists, the structure responds to the dynamics of the soil, while the soil also responds to the dynamics of the structure. Structural response is then governed by the interplay between the characteristics of the ground, the structure and the input motion. This study involved a numerical investigation of the dynamic behaviour of unbraced steel frames resting on soft ground. Two types of mid‐rise unbraced steel frame, including 5‐ and 15‐storey buildings on a soft soil deposit, were selected and analysed under the influence of three different earthquake acceleration records. The above‐mentioned frames were analysed under two different boundary conditions: i) fixed‐base (no soil‐structure interaction) and ii) flexible‐base (considering soil‐structure interaction). The results of the analyses in terms of structural forces and lateral displacements for the above‐mentioned boundary conditions are compared and discussed.
X-ray polarization signals from magnetars with axion-like-particles
Authors: Fortin Jean-François , Sinha Kuver 
Published: January 2019

AbstractAxion-like-particles (ALPs) produced in the core of a magnetar can convert to photons in the magnetosphere, giving rise to novel features in the X-ray spectrum. Since ALPs only mix with the parallel mode of the photon, the polarization of the soft and hard X-ray spectra is predicted to have an O-mode component, in addition to the mainly X-mode component given by most astrophysical models. The relative strength of the O-mode component depends on the intensity of ALPs produced in the core and the probability of conversion. We quantify our results by considering X-ray emission produced both by astrophysical processes and by ALP-photon conversion, in an uncorrelated fashion, and in different relative proportions, which we parametrize by the angleχ0. We then define a normalized astrophysics-subtracted Stokes parameterRwhich only acquires non-zero values in the presence of ALP-photon conversion. We find, remarkably, that the parameterRfactorizes into a product of the ALP-to-photon conversion probability and cos(2χ0) and displayR, as well as the usual Stokes parameterQ, as a function of the photon energy and relative fractions of ALP and photon intensities. For benchmark points currently allowed by the CAST experiment, the O-mode prediction can be tested in future X-ray polarimeters and used either to constrain ALPs or find evidence for them.
From platform dominance to weakened ownership: how external regulation changed Finnish e-identification
Authors: Bazarhanova Anar , Yli-Huumo Jesse , Smolander Kari 
Published: January 2019

AbstractBackgroundThere is substantial interest among scholars in digital platforms and the ecosystems around them. Digital platforms are open, continuously evolving, sociotechnical structures that can be sensitive to various changes.AimWe take one-step further and investigate the post-dominance phase of platforms. The electronic identification (eID) ecosystem in Finland provides a good example of ecosystem transformation due to external changes from EU and national regulation.MethodWe engage in an extensive case study of a nation-wide monopolistic eID platform. We first take a retrospective view to understand the historical context and then examine in detail how an external driver leads to changes in the ecosystem.ResultsWe explicate the platform evolution process, from a phase of dominance with centralized control structures to a more federated governance approach. We find that the introduction of intermediaries between the platform and its users contributes to a weakening of the dominant platform owners.ConclusionThis finding that platforms can transform into industry infrastructures has an important implication for our understanding of the dynamics underlying digital platforms.
Air reverse circulation at the hole bottom in ice-core drilling
Authors: HU ZHENGYI , TALALAY PAVEL , ZHENG ZHICHUAN , CAO PINLU , SHI GUITAO , LI YUANSHENG , FAN XIAOPENG , MA HONGMEI 
Published: January 2019

ABSTRACTIce-core drilling to depths of 200–300 m is an important part of research studies concerned with paleoclimate reconstruction and anthropogenic climate change. However, conventional drilling methods face difficulties due to firn permeability. We have developed an electromechanical ice-core drill with air reverse circulation at the hole bottom. We believe that the new drilling system will recover ice cores faster than shallow auger drills, with high efficiency and low energy consumption. The theoretically estimated up-hole speed of the airflow should be not <7.7 m s−1 to allow proper removal of ice cuttings from the borehole bottom. The computer simulation and test results showed that the design of the new ice-coring drill is feasible. The maximum allowed penetration rate depends by square law on airflow.
The quasi-Assouad dimension of stochastically self-similar sets
Authors: Troscheit Sascha 
Published: January 2019

AbstractThe class of stochastically self-similar sets contains many famous examples of random sets, for example, Mandelbrot percolation and general fractal percolation. Under the assumption of the uniform open set condition and some mild assumptions on the iterated function systems used, we show that the quasi-Assouad dimension of self-similar random recursive sets is almost surely equal to the almost sure Hausdorff dimension of the set. We further comment on random homogeneous and V -variable sets and the removal of overlap conditions.
Non-collapsing in homogeneity greater than one via a two-point method for a special case
Authors: Kröner Heiko 
Published: January 2019

AbstractWe study the mechanism of proving non-collapsing in the context of extrinsic curvature flows via the maximum principle in combination with a suitable two-point function in homogeneity greater than one. Our paper serves as the first step in this direction and we consider the case of a curve which isC2-close to a circle initially and which flows by a power greater than one of the curvature along its normal vector.