bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pediatric Long-Term Endotracheal Intubation and Role for Tracheostomy: Patient and Provider Factors
Authors: Ackerman Kassi , Saley Taylor , Mushtaq Nasir , Carroll Timothy 
Published: November 2018

AbstractTracheostomy provides an alternative to long-term intubation in patients with respiratory failure, but there is little guidance for its use in pediatric patients. Our study used provider surveys of pediatric intensive care physicians managing patients intubated longer than 14 days to evaluate accuracy of physician estimates for total intubation time and the impact of medical history and illness category on determining tracheostomy placement. Providers' ability to estimate length of intubation was found to be highly inaccurate. With delayed tracheostomy conferring increased risk and mortality, better recommendations regarding indication and timing of pediatric tracheostomy placement are needed.
Expressivité et contenus implicites
Authors: Gavrilova Elena , Frison Philippe 
Published: November 2018

RésuméL’expressivité, qui va de pair avec l’énoncé, est un aspect permanent de la traduction. Elle constitue une dimension, implicite ou non, ajoutée au texte en tant que tel. Cependant, les chercheurs divergent sur une définition appropriée. Après en avoir proposé une, nous avons entrepris de montrer à l’aide d’exemples comment ce concept peut aider les traducteurs à mieux adapter leur stratégie aux types de textes à rendre dans la langue d’arrivée.
Translators’ image in Iranian feature films
Authors: Khoshsaligheh Masood , Kafi Mohsen , Narges Noorani Seyede 
Published: November 2018

Abstract
Drawing on the significant influence of audiovisual media on people’s conceptions of any given phenomenon, the current qualitative study
was an attempt to identify the social dimensions of the Iranian translator, represented in feature films in Iran. Specifically,
the study aimed to explore the identity, socioeconomic status and lifestyle of the translator characters depicted in Iranian
feature films. Therefore, 16 Iranian films, involving interlingual translation, were selected. The thematic analysis revealed five
sociological aspects of the Iranian translator reflected in Iranian films: identity of the translator, socioeconomic status of the
translator, lifestyle and attitude of the translator, attitudes of other characters towards the translator, and the role of
translation in the turn of events. The results indicated that translators are generally shown as self-disciplined and dissociable
individuals who are devoted to their work. The translator characters mostly had minor roles in the plot and turn of events.
Conflict in corpora
Authors: Clancy Brian 
Published: November 2018

AbstractThe analysis of conflict in family discourse has often been characterised by ethnographic approaches and/or fine-grained analysis of unique conflict episodes. This article, by contrast, uses a c.175,000-word spoken corpus of Irish family discourse, in conjunction with a corpus pragmatic approach, to explore specific linguistic aspects of conflict discourse. Conflict episodes are identified and analysed in the corpus using a range of linguistic “hooks” (Rühlemann 2010) that have been previously associated with prefacing disagreement such as the markerwell, mitigators (I think, I mean, I guess) or the counterargument strategyyes but. The analysis reveals that the family members most frequently use theyeah butstrategy in conflict episodes which facilitates immediate disagreement. This strategy is often accompanied by a range of mitigators, predominantly in turn final position, some of which have not been previously identified as indexing conflict sequences.
Accusations and interpersonal conflict in televised multi-party interactions amongst speakers of (Argentinian and
Peninsular) Spanish
Authors: Haugh Michael , Sinkeviciute Valeria 
Published: November 2018

Abstract
While there is a growing body of research on impoliteness and conflict talk, the role of accusations in interpersonal conflict has
been only addressed in passing. In this paper, we focus on accusations in conflict talk amongst interactants who are in a
situation demanding the formation of intimate relationships within a relatively short span of time, namely, the television reality
show Big Brother. We examine, in particular, accusation sequences arising in multi-party interactions from the
Argentinian and Spanish versions of the show. We analyse the ways in which assertions of fault or wrongdoing are construed as
accusations through such responses as denials, counter-accusations and challenges, and the ways in which participants explicitly
evaluate each other’s behaviour through such sequences. We conclude that accusations are designed primarily to enact moral
denunciation or condemnation of another party, and so almost invariably occasion interpersonal disputes.
Basque-Spanish bilingual children’s expressive and receptive grammatical abilities
Authors: Anderson Rhiannon M. , Giezen Marcel R. , Pourquié Marie 
Published: November 2018

Abstract
Expressive-receptive gaps in lexical abilities have been documented for bilingual children, but few studies have investigated whether a similar gap is observed at the grammatical level. The current study assessed grammatical abilities through sentence production and comprehension tasks in both languages in 17 Basque-Spanish simultaneous bilingual 6- through 9-year-olds (both languages acquired before three years of age). The children scored lower in Basque than Spanish for sentence production, but no significant differences were found for sentence comprehension. While an expressive-receptive gap was found for both languages, this gap was larger in Basque than in Spanish. Object-verb agreement errors were especially prevalent in Basque production, possibly because verbs in Spanish only agree with the subject. These results demonstrate that expressive-receptive gaps are also observed in bilingual children’s grammatical abilities and may vary depending on the structural similarity between the two languages.
Commodification of women’s breasts
Authors: Correa Doris , Shohamy Elana 
Published: November 2018

Abstract
Cosmetic surgery has become a widespread phenomenon in the last decades, especially in Colombia where a large number of women
undergo it every year. This surgical boom is reflected in several Linguistic Landscape resources including the internet,
where a growing number of cosmetic surgery centers advertise their procedures. Particularly common among these procedures is
breast augmentation, which many Colombian women have at a young age. This article reports on a study which drew on critical linguistic landscape and feminist theories to explore how local cosmetic surgery websites contribute to the commodification of women’s breasts, and its
implications for users of these websites. Data collected for this study included text and images from 12 local websites
advertising cosmetic surgery in Colombia, including breast augmentation. Data analysis showed that these websites contributed to
the commodification of women’s bodies by using a series of ideological mechanisms. Implications for users of these
public spaces include asking critical questions about these websites and becoming more socially active in their consumption.
Gender assignment to Spanish-English mixed DPs
Authors: Casielles-Suárez Eugenia 
Published: November 2018

AbstractPrevious studies on gender assignment to Spanish-English mixed Determiner Phrases (DPs) have noticed a tendency to default to the masculine gender (e.g.el store). However, some studies have revealed that other factors such as the gender of the Spanish translation equivalent (analogical criterion) are also relevant, particularly in written discourse (e.g.la conference). Further, it has been hypothesized that feminine-marked mixed DPs in oral discourse, which are viewed as exceptions to the default gender strategy, should be highly restricted to singleton switches (Valdés Kroff 2016). This paper investigates if feminine-marked mixed DPs are restricted to singleton switches in written discourse by analyzing a mixed-language text, which contains both types of switches (singleton and multiword). The results confirm the importance of the analogical criterion in written discourse and show that feminine-marked DPs are not restricted to singleton switches, and that the analogical criterion is relevant to both singleton and multiword switches.
Selling cheese online
Authors: Ramón Noelia , Labrador Belén 
Published: November 2018

AbstractThis paper is a corpus-based study of certain key nouns used in promotional texts describing cheese in English. A corpus of online cheese descriptions was compiled to extract lexical information regarding the characterization of cheese. All in all, 37 key nouns were identified and classified into 7 semantic categories: appearance, part, colour, aroma, texture, taste and quality ranking. All the occurrences of each key noun were analysed to obtain an exhaustive inventory of the phraseological patterns in which they occur. The results show both objective characteristics (size, shape and colour) and subjective features which tend to be described positively in this promotional subgenre (aroma, texture and taste). Additionally, this text type includes key nouns related to the quality ranking of the cheeses promoted. The main aim of this paper is to gain insight into one particular subgenre – promotional cheese descriptions – through the major lexical co-occurrences used to convey positive evaluation of cheeses.
Towards finding a difficulty index for English grammatical terminology
Authors: Yousefpoori-Naeim Mehrdad , Baleghizadeh Sasan 
Published: November 2018

Abstract
Despite going through some ups and downs, grammar teaching has always been one of the central issues in the history of second
language teaching. In order to teach grammar, teachers frequently get involved in metalanguage, which has grammatical terminology
as one of its major components. Since the nature and use of grammatical terminology in language teaching has remained a
considerably under-researched area to the day, the present study, originally a doctoral dissertation, was an attempt to find a
difficulty index for a more or less comprehensive list of English grammatical terms, collected from various sources of English
grammar. For this purpose, frequency of terms in a researcher-built corpus of EFL/ESL pedagogic grammar textbooks and English
students’ familiarity with the terms were used as the two main criteria for calculating the difficulty index. A corpus of 14
grammatical textbooks was created, and then each of the 459 terms in the list was searched for in the textbooks to calculate their
frequencies as well as ranks in the corpus. Student familiarity with the terms in the list was also measured through a productive
test of grammatical terminology administered to 72 BA students of English at Shahid Beheshti University in Iran. Based on the
results, the traditional dichotomy of scientific versus pedagogic terminology was questioned, arguing for an additional category,
non-pedagogic term. Accordingly, 173 (37.7%) of the terms in the list never appeared in the corpus and thus
were labelled non-pedagogic. Terms with a large corpus/test rank were reanalyzed to find out about the reasons for the gap.
Furthermore, the distribution of terms across the corpus textbooks revealed that as the level of the books rises, the number of
terms also increases, indicating the direct relationship between second language proficiency and metalingual knowledge. Most
importantly, more than 10 major and minor trends in the use of grammatical terminology in pedagogy were explored and suggested.
Finally, as the output of the study, 6 equivalent objective tests of pedagogic grammatical terminology were developed for the
first time in the literature.
Conceptualization and theorization of terminology translation in humanities and social sciences
Authors: Wei Xiangqing 
Published: November 2018

Abstract
In recent decades, the scope of terminology research has been extended. The peculiarities and complexities of terminology are
further ascertained by the exploration into the practice of terminology translation in the field of humanities and social
sciences. The cultural functions that terminology in this research field (H&SS terms) fulfill and the intrinsic difficulties
involved in translating them are worth further investigation. This paper based on some reflections of the development of the
NUTermBank discusses the legitimacy of terminology translation as independent research and makes an initial attempt to theorize
about how the research can be actually carried out. A holistic view of terminology translation is taken and a 3-M research model
is proposed in this paper.
Drp1-dependent mitochondrial fission regulates p62-mediated autophagy in LPS-induced activated microglial cells
Authors: Chae Unbin , Kim Han Seop , Lee Hyun-Shik , Lee Sang-Rae , Lee Dong-Seok 
Published: November 2018

ABSTRACTMicroglial activation is known to be an important event during innate immunity, but microglial inflammation is also thought to play a role in the etiology of neurodegenerative diseases. Recently, it was reported that autophagy could influence inflammation and activation of microglia. However, little is known about the regulation of autophagy during microglial activation. In this study, we demonstrated that mitochondrial fission-induced ROS can promote autophagy in microglia. Following LPS-induced autophagy, GFP-LC3 puncta were increased, and this was suppressed by inhibiting mitochondrial fission and mitochondrial ROS. Interestingly, inhibition of mitochondrial fission and mitochondrial ROS also resulted in decreased p62 expression, but Beclin1 and LC3B were unaffected. Taken together, these results indicate that ROS induction due to increased LPS-stimulated mitochondrial fission triggers p62 mediated autophagy in microglial cells. Our findings provide the first important clues towards understanding the correlation between mitochondrial ROS and autophagy.Abbreviations: Drp1; Dynamin related protein 1, LPS; Lipopolysaccharide, ROS; Reactive Oxygen Species, GFP; Green Fluorescent Protein, CNS; Central Nervous System, AD; Alzheimer’s Disease, PD; Parkinson’s Disease, ALIS; Aggresome-like induced structures, iNOS; inducible nitric oxide synthase, Cox-2; Cyclooxygenase-2, MAPK; Mitogen-activated protein kinase; SODs; Superoxide dismutase, GPXs; Glutathione Peroxidase, Prxs; Peroxiredoxins
Pantothenate auxotrophy of Methylobacterium spp. isolated from living plants
Authors: Yoshida Yusuke , Iguchi Hiroyuki , Sakai Yasuyoshi , Yurimoto Hiroya 
Published: November 2018

ABSTRACT
A number of pink-pigmented facultative methylotrophs (PPFMs) belonging to Methylobacterium spp. isolated from living plant samples were found to require B vitamins for their growth in minimal medium, and most B vitamin-auxotrophic PPFMs required pantothenate (vitamin B5). Further investigation of pantothenate auxotrophy using the representative strain Methylobacterium sp. OR01 demonstrated that this strain cannot synthesize β-alanine, one of the precursors of pantothenate. β-alanine and several precursors of pantothenate restored the growth of Methylobacterium sp. OR01 in minimal medium. Furthermore, this strain could colonize leaves of Arabidopsis thaliana cultivated in medium without pantothenate or its precursors. Pantothenate, β-alanine and several precursors were detected in the suspension of A. thaliana leaves. These results suggest that pantothenate-auxotrophic PPFMs can symbiotically colonize the surface of plant leaves by acquiring β-alanine and other precursors, in addition to pantothenate. Finally, the fitness advantage of B vitamin auxotrophy of PPFMs in the phyllosphere environment is discussed.
Homeolog expression quantification methods for allopolyploids
Authors: Kuo Tony C Y , Hatakeyama Masaomi , Tameshige Toshiaki , Shimizu Kentaro K , Sese Jun 
Published: November 2018

Abstract
Genome duplication with hybridization, or allopolyploidization, occurs in animals, fungi and plants, and is especially common in crop plants. There is an increasing interest in the study of allopolyploids because of advances in polyploid genome assembly; however, the high level of sequence similarity in duplicated gene copies (homeologs) poses many challenges. Here we compared standard RNA-seq expression quantification approaches used currently for diploid species against subgenome-classification approaches which maps reads to each subgenome separately. We examined mapping error using our previous and new RNA-seq data in which a subgenome is experimentally added (synthetic allotetraploid Arabidopsis kamchatica) or reduced (allohexaploid wheat Triticum aestivum versus extracted allotetraploid) as ground truth. The error rates in the two species were very similar. The standard approaches showed higher error rates (&gt;10% using pseudo-alignment with Kallisto) while subgenome-classification approaches showed much lower error rates (&lt;1% using EAGLE-RC, &lt;2% using HomeoRoq). Although downstream analysis may partly mitigate mapping errors, the difference in methods was substantial in hexaploid wheat, where Kallisto appeared to have systematic differences relative to other methods. Only approximately half of the differentially expressed homeologs detected using Kallisto overlapped with those by any other method in wheat. In general, disagreement in low-expression genes was responsible for most of the discordance between methods, which is consistent with known biases in Kallisto. We also observed that there exist uncertainties in genome sequences and annotation which can affect each method differently. Overall, subgenome-classification approaches tend to perform better than standard approaches with EAGLE-RC having the highest precision.
BlendMol: advanced macromolecular visualization in Blender
Authors: Durrant Jacob D 
Published: November 2018

Abstract

Summary
Programs such as VMD and PyMOL are excellent tools for analyzing macromolecular structures, but they do not implement many of the advanced rendering techniques common in the film and video-game industries. In contrast, the open-source program Blender is a general-purpose tool for industry-standard rendering/visualization, but its user interface is poorly suited for rigorous scientific analysis. We present BlendMol, a Blender plugin that imports VMD or PyMOL scenes into Blender. BlendMol-generated images are well suited for use in manuscripts, outreach programs, websites and classes.

Availability and implementation
BlendMol is available free of charge from http://durrantlab.com/blendmol/. It is written in Python.

Supplementary information
Supplementary data are available at Bioinformatics online.
Computational modeling reveals MAP3K8 as mediator of resistance to vemurafenib in thyroid cancer stem cells
Authors: Gianì Fiorenza , Russo Giulia , Pennisi Marzio , Sciacca Laura , Frasca Francesco , Pappalardo Francesco 
Published: November 2018

Abstract

Motivation
Val600Glu (V600E) mutation is the most common BRAF mutation detected in thyroid cancer. Hence, recent research efforts have been performed trying to explore several inhibitors of the V600E mutation-containing BRAF kinase as potential therapeutic options in thyroid cancer refractory to standard interventions. Among them, vemurafenib is a selective BRAF inhibitor approved by Food and Drug Administration for clinical practice. Unfortunately, vemurafenib often displays limited efficacy in poorly differentiated and anaplastic thyroid carcinomas probably because of intrinsic and/or acquired resistance mechanisms. In this view, cancer stem cells (CSCs) may represent a possible mechanism of resistance to vemurafenib, due to their self-renewal and chemo resistance properties.

Results
We present a computational framework to suggest new potential targets to overcome drug resistance. It has been validated with an in vitro model based upon a spheroid-forming method able to isolate thyroid CSCs that may mimic resistance to vemurafenib. Indeed, vemurafenib did not inhibit cell proliferation of BRAF V600E thyroid CSCs, but rather stimulated cell proliferation along with a paradoxical over-activation of ERK and AKT pathways. The computational model identified a fundamental role of mitogen-activated protein kinase 8 (MAP3K8), a serine/threonine kinase expressed in thyroid CSCs, in mediating this drug resistance. To confirm model prediction, we set a suitable in vitro experiment revealing that the treatment with MAP3K8 inhibitor restored the effect of vemurafenib in terms of both DNA fragmentation and poly (ADP-ribose) polymerase cleavage (apoptosis) in thyroid CSCs. Moreover, MAP3K8 expression levels may be a useful marker to predict the response to vemurafenib.

Availability and implementation
The model is available in GitHub repository visiting the following URL: https://github.com/francescopappalardo/MAP3K8-Thyroid-Spheres-V-3.0.

Supplementary information
Supplementary data are available at Bioinformatics online.
Aging-Related Changes in Cognition and Cortical Integrity are Associated With Serum Expression of Candidate MicroRNAs for Alzheimer Disease
Authors: Maldonado-Lasuncion Ines , Atienza Mercedes , Sanchez-Espinosa Mayely P , Cantero Jose L 
Published: November 2018

AbstractEvidence has shown that microRNAs (miRNAs) are involved in molecular pathways responsible for aging and prevalent aging-related chronic diseases. However, the lack of research linking circulating levels of miRNAs to changes in the aging brain hampers clinical translation. Here, we have investigated if serum expression of brain-enriched miRNAs that have been proposed as potential biomarkers in Alzheimer’s disease (AD) (miR-9, miR-29b, miR-34a, miR-125b, and miR-146a) are also associated with cognitive functioning and changes of the cerebral cortex in normal elderly subjects. Results revealed that candidate miRNAs were linked to changes in cortical thickness (miR-9, miR-29b, miR-34a, and miR-125b), cortical glucose metabolism (miR-29b, miR-125b, and miR-146a), and cognitive performance (miR-9, miR-34a, and miR-125b). While both miR-29b and miR-125b were related to aging-related structural and metabolic cortical changes, only expression levels of miR-125b were associated with patterns of glucose consumption shown by cortical regions that correlated with executive function. Together, these findings suggest that serum expression of AD-related miRNAs are biologically meaningful in aging and may play a role as biomarkers of cerebral vulnerability in late life.
A Mellin transform approach to barrier option pricing
Authors: Guardasoni Chiara , Rodrigo Marianito R , Sanfelici Simona 
Published: November 2018

AbstractA barrier option is an exotic path-dependent option contract that, depending on terms, automatically expires or can be exercised only if the underlying asset ever reaches a predetermined barrier price. Using a partial differential equation approach, we provide an integral representation of the barrier option price via the Mellin transform. In the case of knock-out barrier options, we obtain a decomposition of the barrier option price into the corresponding European option value minus a barrier premium. The integral representation formula can be expressed in terms of the solution to a system of coupled Volterra integral equations of the first kind. Moreover, we suggest some possible numerical approaches to the problem of barrier option pricing.
Minimal Asymptotic Translation Lengths of Torelli Groups and Pure Braid Groups on the Curve Graph
Authors: Baik Hyungryul , Shin Hyunshik 
Published: November 2018

Abstract
In this paper, we show that the minimal asymptotic translation length of the Torelli group ${\mathcal{I}}_g$ of the surface $S_g$ of genus $g$ on the curve graph asymptotically behaves like $1/g$, contrary to the mapping class group ${\textrm{Mod}}(S_g)$, which behaves like $1/g^2$. We also show that the minimal asymptotic translation length of the pure braid group ${\textrm{PB}}_n$ on the curve graph asymptotically behaves like $1/n$, contrary to the braid group ${\textrm{B}}_n$, which behaves like $1/n^2$.