bluuebunny/crossref_metadata_2025_split huggingface dataset:
Plectin is Required for Trans‐Endothelial Permeability: A Model of Plectin Dysfunction in Human Endothelial Cells After TNF‐α Treatment and Dengue Virus Infection
Authors: Suttitheptumrong Aroonroong , Rawarak Nantapon , Reamtong Onrapak , Boonnak Kobporn , Pattanakitsakul Sa‐nga 
Published: October 2018

AbstractThe clinical sign of dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS) in humans is increased vascular permeability. Virus‐specific factors and host factors, including secreted cytokines and especially TNF‐α, are suggested as having roles in the pathogenesis of these conditions. Proteomic analysis with MS is performed in membrane fraction isolated from human endothelial cells (EA.hy926) upon DENV infection and TNF‐α treatment. In the 451 altered proteins that are identified, decreased plectin expression is revealed by Western blot analysis, while immunofluorescence staining (IFA) shows actin stress fiber rearrangement and decreased VE‐cadherin in treated EA.hy926 cells. In vitro vascular permeability assay was used to determine transepithelial electrical resistance (TEER) in EA.hy926 cells seeded on collagen‐coated Transwell inserts. The low level of TEER, the low expression of plectin and VE‐cadherin, and the unusual organization of actin stress fiber are found to be correlated with increased membrane permeability in DENV2 and TNF‐α‐treated EA.hy926 cells. Similar results are observed when using siRNA knockdown plectin in mock EA.hy926 cells. This study provides better understanding of the role that disruption of cytoskeleton linker protein plays in increased vascular permeability, and suggests these factors as major contributors to vascular leakage in DHF/DSS patients.
Me3SiBr/InCl3 catalyzed allylation of alcohols: Identifying the combined Lewis structure and investigating the reaction mechanism
Authors: Liu Changmei , Sang Shenglong , Chen Fei , Yan Yan , Zhang Cong , Huang Wei 
Published: October 2018

AbstractThe combined Lewis acid Me3SiBr/InCl3 shows unique performance in multireactions. The topology and catalytic properties of Me3SiBr/InCl3 were investigated by DFT method for clarifying the nature of chemical bonds and interactions. Quantum theory of atoms in molecules (QTAIM) analysis showed that the interaction between Me3Si‐halide and In‐trihalide mainly belongs to the closed‐shell interaction. Natural bond order of Br─In is 0.610 in INT_0 while natural bond order of Cl─In in INT_1 is only 0.081 at SMD‐ωB97XD/def2‐SVP level. The coupling reaction mechanism of alcohol and allyltrimethylsilane catalyzed by the complex of Me3SiBr/InCl3 was investigated with DFT method. The combined Lewis acid activates the hydroxyl group by strong coordination to silicone center, which leads to the generation of carbocation. Me3Si+ moiety from the combined Lewis acid is consumed and converts into the side product Me3SiOSiMe3. Furthermore, the reactant allyltrimethylsilane is introduced into the system to bring out the final product, and the complex Me3SiBr/InCl3 is reproduced at the same time. The combined Lewis acid Me3SiBr/InCl3 not only works as the catalyst for the reaction but also involves in the generation of side product.
UltraMassExplorer: a browser‐based application for the evaluation of high‐resolution mass spectrometric data
Authors: Leefmann Tim , Frickenhaus Stephan , Koch Boris P. 
Published: October 2018

RationaleHigh‐resolution mass spectrometry (HRMS) with high sample throughput has become an important analytical tool for the analysis of highly complex samples and data processing has become a major challenge for the user community. Evaluating direct‐infusion HRMS data without automated tools for batch processing can be a time‐consuming step in the analytical pipeline. Therefore, we developed a new browser‐based software tool for processing HRMS data.MethodsThe software, named UltraMassExplorer (UME), was written in the R programming language using the shiny library to build the graphical user interface. The performance of the integrated formula library search algorithm was tested using HRMS data derived from analyses of up to 50 extracts of marine dissolved organic matter.ResultsThe software supports the processing of lists of calibrated masses of neutral, protonated or deprotonated molecules, with masses of up to 700 Da and a mass accuracy <3 ppm. In the performance test, the number of assigned peaks per second increased with the number of submitted peaks and reached a maximum rate of 4745 assigned peaks per second.ConclusionsUME offers a complete data evaluation pipeline comprising a fast molecular formula assignment algorithm allowing for the swift reanalysis of complete datasets, advanced filter functions and the export of data, metadata and publication‐quality graphics. Unique to UME is a fast and interactive connection between data and their visual representation. UME provides a new platform enabling an increased transparency, customization, documentation and comparability of datasets.
Robust vertex‐dependent H∞ and H2 estimation for stochastic linear systems
Authors: Gershon E. , Shaked U. 
Published: October 2018

SummaryWe consider linear continuous‐time systems with multiplicative noise and polytopic‐type parameter uncertainty, and we address the problems of H∞ and H2 filtering of these systems. These problems are solved by applying a vertex‐dependent Lyapunov function that considerably reduces the overdesign associated with the classical design that is based on a single Lyapunov function for the whole parameter range. A new approach of the Finsler lemma is used that decreases the overdesign entailed in the usual derivation of the robust estimation problem. The developed theory is also extended to the robust gain scheduling case where online measurement is used to improve the estimation. Two examples are given that demonstrate the tractability and applicability of the design methods.
Tunable Physicochemical and Bactericidal Activity of Multicarboxylic‐Acids‐Crosslinked Polyvinyl Alcohol Membrane for Food Packaging Applications
Authors: Suganthi Sanjeevamuthu , Mohanapriya Subramanian , Raj Vairamuthu , Kanaga Selvaraj , Dhandapani Ramamurthy , Vignesh Shanmugam , Kalyana Sundar Jeyaperumal 
Published: October 2018

AbstractThe present study demonstrates the role of multicarboxylic acids as crosslinkers to polyvinyl alcohol (PVA) films were fabricated by solution casting method for food packing applications. Effect of incorporating different carboxylic acids namely oxalic acid (OA), succinic acid (SA) and citric acid (CA) on physicochemical and bioactive properties of PVA were investigated in detail. The crystalline phase, optical absorptions and the functional group were analyzed through X‐Ray diffraction (XRD), UV‐Vis and Fourier Transform Infrared (FTIR) Spectroscopy. Thermal, microstructure and surface analysis were studied by Differential thermal analysis (TG/DTA) and Scanning Electron Microscope (SEM) analysis and the chief anti‐bacterial activity. The rheological study was carried out using precursor polymer solutions with different crosslinkers reveal that viscosity of PVA/CA solution is higher. Surface topography and roughness exert a strong influence on bactericidal properties of films as evidenced by Atomic Force Microscope (AFM) analysis. Among they studied films, PVA/CA exhibits higher bacterial inhibition efficiency mainly due to the ability of CA to alter local pH and cause an alteration in the permeability of microbial membrane by disrupting bacterial substrate transport. In addition to this food quality analysis results of microbial tests revealed an increase in the microbial shelf life of sliced carrot from 1 to 5 days for PVA/CA film compared to the control and commercial.
Alternative Biofuel Materials for Microbial Fuel Cells from Poplar Wood
Authors: Erensoy Ahmet , Çek Nurettin 
Published: October 2018

AbstractIn this study, biofuel properties of poplar wood materials rich in organic materials were investigated for microbial fuel cells. Therefore, in this study, investigates the chemical, biochemical properties with electrochemical performance of single chamber microbial fuel cell manufactured using poplar biomass materials, natural soil, graphite anode electrode and graphite cathode electrode. With the increase in the weight of the poplar tree in the microbial fuel cells, the power density increased. SEM, EDS, FTIR analyses showed that bacillus and coccus type bacteria in the natural structure of the soil act as the catalyst in the anode electrode. Poplar wood, electrodes and bacteria have served in harmony. According to experimental results, the maximum power reaches to 16.88 mW and microbial fuel cell successfully displays a maximum power density of 8555 mW/m2. All these results indicate that poplar wood may be appropriate biofuel sources for electrical energy generation as an effective environmentally microbial fuel cell technology.
Conformation Specific Binding of [Ru(phen)2(dppz)]2+ with Mono‐ and Cluster Arylamine‐DNA Adducts
Authors: Thangavel Nandhini , Ganesan Vaidyanathan V. , Nair Balachandran U. 
Published: October 2018

AbstractThe development of any probe to detect cluster adducts requires an in depth understanding on the binding affinity of probes to these adducts. In this context, we attempted to study the interaction of known DNA molecular switch [Ru(phen)2(dppz)]2+ with mono‐ and cluster DNA adducts in 16‐mer NarI sequence (5′‐CTCTCG1G2CG3CCATCAC‐3′) where guanine bases are modified with N‐acetyl‐2‐aminofluorene(AAF). Luminescence studies show that [Ru(phen)2(dppz)]2+ (phen: 1,10‐phenanthroline and dppz: dipyrido[3,2‐a:2′,3′‐c]phenazine) binds to AAF adduct at G1 and G3 which possesses minor‐groove(W) and stacked conformation(S) exhibit two fold enhancement while G2 with major groove B‐conformer exhibit 1.6 fold enhancement when compared to control. In diadducts, RuII binds to G2G3 AAF adduct lower than that of other two diadducts G1G3 and G1G2. With triadducts, phenazine moiety of RuII complex adopts canted geometry to the DNA due to the very unstable structure at the adducted site. From microscale thermophoretic data, the kd of RuII was determined and found to be consistent with luminescence data. The present study provides an overall insight of role of conformation of AAF structure embedded in different sequence context that dictates the sensitivity of the DNA molecular light switch, in turn, facilitates in developing highly efficient probe to distinguish these cluster adducts.
Synthesis of 7H‐Indolo[2,3‐c]quinolines by Chemoselective Suzuki Reaction Followed by a Ring‐Closing Two‐Fold Buchwald‐Hartwig Reaction of 3‐Bromo‐4‐iodoquinoline
Authors: Rivera Rodisnel Perdomo , Ehlers Peter , Rodríguez Eugenio Torres , Langer Peter 
Published: October 2018

AbstractN‐functionalized 7H‐indolo[2,3‐c]quinolines have been synthesized by chemoselective Suzuki‐reaction followed by a ring‐closing two‐fold Buchwald‐Hartwig reaction. The developed methodology allows the application of various anilines, benzyl amines as well as aliphatic amines and led to corresponding products in high yields.
HClO4⋅SiO2‐Catalyzed Mechanochemical Protocol: An Effective, Economical and Eco‐friendly Preparation of N‐(tert‐butylsulfinyl)imines
Authors: Appa Rama Moorthy , Lakshmidevi Jangam , Prasad S. Siva , Naidu Bandameeda Ramesh , Narasimhulu Manchala , Venkateswarlu Katta 
Published: October 2018

AbstractThe imines of Ellman's tert‐butylsulfinamides have become one of the elementary substrates for the construction of chiral precursors and complex organic molecules. This article reports a mechanochemical access to imines of chiral tert‐butylsulfinamides with a variety of aldehydes using solid acid catalyst, perchloric acid‐silica (HClO4⋅SiO2) at innocuous reaction environs. The conversion can be carried out at ambient temperature under solvent and metal‐free conditions by (hand) grinding the contents in a mortar at open‐air. The current protocol is highly economical, allows large‐scale preparation, offers a very good to nearly quantitative yields of imines in short reaction times with no product racemization and doesn′t necessitate the moisture‐free conditions.
Theoretical Insights on A series of Cyclic Energetic Derivatives
Authors: Jin Xinghui , Xiao Menghui , Ding Yunqiao , Zhou Jianhua , Hu Bingcheng 
Published: October 2018

AbstractCyclic energetic derivatives based on guanidine and 1,1‐diaminoethene were designed and investigated systematically using density functional theory methods. The optimized geometry, heats of formation, heats of detonation, detonation velocities, detonation pressures as well as bond dissociation energies were calculated at the B3LYP/6‐31G(d,p) level. It is found that the parent molecules possess high positive heats of formation (from 196.3 to 367.1 kJ mol−1) which in turn will lead to the high positive heats formation of the designed compounds (from 340.2 to 1312.8 kJ mol−1). Besides, all the designed compounds have acceptable detonation properties (heats of detonation, from 434.3 to 2006.6 cal g−1; densities, from 1.49 to 2.38 g cm−3; detonation velocities, from 6.14 to 11.7 km s−1; detonation pressures, from 14.9 to 67.7 GPa) and moderated thermal stabilities (bond dissociation energies were from 11.3 to 118.9 kJ mol−1). Take both of detonation properties and thermal stabilities into consideration, compounds A4, B4, C1, C2, C4 and D4 were regarded as the promising candidates for high energy density materials. Finally, frontier molecular orbitals, electronic densities and electrostatic potentials of compounds A4, B4, C1, C2, C4 and D4 were also simulated. All the presented data may provide comprehensive information on laboratory synthesis, physical and chemical properties of these promising explosives.
Enhanced Visible‐Light‐Driven Activity of Sodium‐, Calcium‐ and Aluminium‐Inserted g‐C3N4
Authors: Islam M. Merajul , Tentu Rama D. , Ali M. Asif , Basu Suddhasatwa 
Published: October 2018

Abstractg‐C3N4 has emerged as a promising low‐cost metal free photocatalyst with ideal optical‐electronic properties; however, high recombination rate is one of the barriers associated with its low photocatalytic activity. Al and Ca intercalated g‐C3N4 photocatalysts with superior visible‐light utilization and charge‐carrier have been synthesized using one‐step thermal condensation method. An enhanced visible‐light harvesting capacity due to a red shift in the optical band gap of inserted g‐C3N4 photocatalysts was observed. The charge‐transfer, its kinetics across the interface and electron‐hole pairs separations were systematically investigated using photoelectrochemical measurements. The evaluation of photocatalytic activity of Al and Ca intercalated g‐C3N4 through degradation of RhB dye revealed 4.6 and 2.5 fold improvement in performance of g‐C3N4. Al intercalated g‐C3N4 shows highest photocurrent density, lowest Tafel slope and highest exchange‐current density due to least recombination rate of photo generated charge‐carriers, facile kinetics and least charge‐transfer resistance without use of any noble metal co‐catalyst towards oxygen evolution reaction (OER) with excellent stability.
The onboard software of the EUSO‐SPB pathfinder experiment
Authors: Fornaro Claudio , Cafagna Francesco Saverio , Osteria Giuseppe , Scotti Valentina , Perfetto Francesco , Conti Livio 
Published: October 2018

SummaryIn this paper, the flight software architecture of the EUSO‐SPB mission is described. The JEM‐EUSO program aims at developing an advanced large space‐borne UV telescope designed to detect ultra high energy cosmic rays. In this framework, the EUSO‐SPB experiment is the third pathfinder mission of the JEM‐EUSO program, the second that has been launched on a stratospheric balloon to test the technological readiness of the detectors and to carry out some preliminary scientific observations. The EUSO‐SPB software has a modular structure conceived to control all the instruments and the ancillary subsystems, to acquire data, and to manage data transfer to ground. System programming in C and C++ languages and Bash scripts have been used to implement and run the modules. The software runs on the data processor, an onboard computer that communicates with several payload blocks, the UV sensor, and the synchronization and time tagging board. The control software module controls all the subsystems, provides communication to ground through the NASA telemetry or the Internet, runs the acquisition control and download software, and manages the execution of the acquisition software. The acquisition software module directly operates the subsystems for the data acquisition activity. The acquisition control and download software module runs the acquisition software upon request of the control software and transfers scientific data to ground. The software system performed as expected during the flight on April 2017.
Comprehensive understanding of risk and protective factors related to adolescent pregnancy in low‐ and middle‐income countries: A systematic review
Authors: Chung Hye Won , Kim Eun Mee , Lee Ji‐Eun 
Published: October 2018

ABSTRACTIntroductionAdolescent pregnancy causes serious problems not only for girls, but also for their family, and society. This study aimed to understand factors related to adolescent pregnancy in low‐ and middle‐income countries using a multilevel approach adopted by Bronfenbrenner's ecological model.MethodsA total of 11,933 studies published in between 2000 and 2015 were identified in 4 databases. Based on inclusion criteria and risk of bias assessment, a total of 67 articles were retrieved for analysis.ResultsThematic analysis revealed that early marriage, sexual risk behaviors, substance use, family experience of adolescent birth, peer pressure, and lack of sex education and health service increased the hazards of adolescent pregnancy. Communication with parents, school activities, community meetings, laws, and government policies protected adolescents from pregnancy.ConclusionsResults of this study suggests that the background of adolescents and complex interactions among various factors should be considered for pregnancy. In future research, mixed‐method that supplements the methodological weaknesses of previous studies is also recommended.
The impact of single engine taxiing on aircraft fuel consumption and pollutant emissions
Authors: Stettler M. E. J. , Koudis G. S. , Hu S. J. , Majumdar A. , Ochieng W. Y. 
Published: October 2018

ABSTRACTOptimisation of aircraft ground operations to reduce airport emissions can reduce resultant local air quality impacts. Single engine taxiing (SET), where only half of the installed number of engines are used for the majority of the taxi duration, offers the opportunity to reduce fuel consumption, and emissions of NOX, CO and HC. Using 3510 flight data records, this paper develops a model for SET operations and presents a case study of London Heathrow, where we show that SET is regularly implemented during taxi-in. The model predicts fuel consumption and pollutant emissions with greater accuracy than previous studies that used simplistic assumptions. Without SET during taxi-in, fuel consumption and pollutant emissions would increase by up to 50%. Reducing the time before SET is initiated to the 25th percentile of recorded values would reduce fuel consumption and pollutant emissions by 7–14%, respectively, relative to current operations. Future research should investigate the practicalities of reducing the time before SET initialisation so that additional benefits of reduced fuel loadings, which would decrease fuel consumption across the whole flight, can be achieved.
Advanced gas turbine performance modelling using response surface methods
Authors: Seetharama-Yadiyal V. , Brighenti G.D. , Zachos P.K. 
Published: October 2018

ABSTRACTSurrogate models are widely used for dataset correlation. A popular application very frequently shown in public literature is in the field of engineering design where a large number of design parameters are correlated with performance indices of a complex system based on existing numerical or experimental information. Such an approach allows the identification of the key design parameters and their impact on the system’s performance. The generated surrogate model can become part of wider computational platforms and enable optimisation of the complex system without the need to run expensive simulations.In this paper, a number of design point simulations for a combined gas-steam cycle are used to generate a response surface. The generated response surface correlates a range of cycle’s key design parameters with its thermal efficiency while it also enables identification of the optimum overall pressure ratio and the high pressure level of the raised steam across a range of recuperator effectiveness, pinch temperature difference across the heat recovery steam generator and the pressure at the condenser. The accuracy of a range of surrogate models to capture the design space is evaluated using root mean square statistical metrics.
Anger in infancy and its implications: History of attachment in mother–child and father–child relationships as a moderator of risk
Authors: Brock Rebecca L. , Kochanska Grazyna 
Published: October 2018

AbstractGrowing research has documented distinct developmental sequelae in insecure and secure parent–child relationships, supporting a model of early attachment as moderating future developmental processes rather than, or in addition to, a source of direct effects. We explored maladaptive developmental implications of infants’ anger proneness in 102 community families. Anger was assessed in infancy through observations in the Car Seat episode and parents’ ratings. Children's security with parents was assessed in the Strange Situation paradigm at 15 months. At preschool age, child negativity (defiance and negative affect) was observed in interactions with the parent, and at early school age, oppositionality was rated by parents and teachers. Security was unrelated to infant anger; however, it moderated associations between infant anger and future maladaptive outcomes, such that highly angry infants embarked on a negative trajectory in insecure, but not in secure, parent–child dyads. For insecure, but not secure, mother–child dyads, infants’ mother-rated anger predicted negativity at preschool age. For insecure, but not secure, father–child dyads, infants’ anger in the Car Seat predicted father- and teacher-rated oppositional behavior at early school age. Results highlight the developmentally complex nature of the impact of attachment, depending on the relationship with mother versus father, type of measure, and timing of effects.
Landscape archaeology and urbanism at Meninx: results of geophysical prospection on Jerba (2015)
Authors: Ritter Stefan , Ben Tahar Sami , Fassbinder Jörg W. E. , Lambers Lena 
Published: October 2018

This paper presents the results of the geophysical prospection conducted at the site of Meninx (Jerba) in 2015. This was the first step in a Tunisian-German project (a cooperation between the Institut National du Patrimoine, Tunis, and the Institut für Klassische Archäologie der Ludwig-Maximilans-Universität München), the aim of which is to shed light on the urban history of the most important city on the island of Jerba in antiquity.Meninx, situated on the SE shore of the island (fig. 1), was the largest city on Jerba during the Roman Empire and eponymous for the island's name in antiquity. The outstanding importance of this seaport derived from the fact that it was one of the main production centers of purple dye in the Mediterranean. With the earliest secure evidence dating to at least the Hellenistic period, Meninx saw a magnificent expansion in the 2nd and 3rd c. A.D. It was inhabited until the 7th c. when the city was finally abandoned.