bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cassini Ring Seismology as a Probe of Saturn’s Interior. I. Rigid Rotation
Authors: Mankovich Christopher , Marley Mark S. , Fortney Jonathan J. , Movshovitz Naor 
Published: January 2019

Abstract
Seismology of the gas giants holds the potential to resolve long-standing questions about their internal structure and rotation state. We construct a family of Saturn interior models constrained by the gravity field and compute their adiabatic mode eigenfrequencies and corresponding Lindblad and vertical resonances in Saturn’s C ring, where more than 20 waves with pattern speeds faster than the ring mean motion have been detected and characterized using high-resolution Cassini Visual and Infrared Mapping Spectrometer stellar occultation data. We present identifications of the fundamental modes of Saturn that appear to be the origin of these observed ring waves, and we use their observed pattern speeds and azimuthal wavenumbers to estimate the bulk rotation period of Saturn’s interior to be

(median and 5%/95% quantiles), significantly faster than Voyager and Cassini measurements of periods in Saturn’s kilometric radiation, the traditional proxy for Saturn’s bulk rotation period. The global fit does not exhibit any clear systematics indicating strong differential rotation in Saturn’s outer envelope.
Association of common IL-10 promoter gene variants with the susceptibility to head and neck cancer in Tunisia
Authors: MAKNI LAMIA , BEN HAMDA CHERIF , AL ANSARI ABRAR , SOUAIAI OUSSEMA , GAZOUANI EZZEDINE , MEZLINI AMEL , Y ALMAWI WASSIM , YACOUBI-LOUESLATI BESMA 
Published: January 2019

Background/aim : We investigated the association of three IL-10 promoter single-nucleotide polymorphisms and altered IL-10 plasma levels with the risk of head and neck cancer (HNC).
Material and methods : Study subjects comprised 194 HNC patients [137 nasopharyngeal cancer (NPC) and 57 laryngeal cancer (LC)], and 263 healthy controls. Genotyping of rs1800896 (-1082A>G), rs1800871 (-819C>T), and rs1800872 (-592A>C) IL-10 variants was performed by real-time PCR; IL-10 levels were measured by Enzyme Amplified Immuno Sensitivity Assay (EAISA).
Results : Carriage of rs1800896 A/A genotype was more frequent in HNC and NPC cases, but was less frequent in controls than LC patients. Significant differences in IL-10 levels was seen between rs1800896A/G genotype-carrying NPC cases and controls. Positive association with NPC and LC was seen for rs1800871C/C, and carriage of rs1800872A/A genotype and A allele were associated with higher risk of HNC and NPC, but not LC. GT rs1800896-rs1800871 haplotype was more frequent among HNC and NPC cases than controls, in contrast to GC haplotype, which has a protective effect. Positive association was found between TA haplotype and LC.
Conclusion : Our results demonstrate that IL-10-1082, IL-10-819 and IL-10-592 variants, and haplotypes GC and GT constitute biomarkers for early detection of HNC, especially NPC subtype. IL-10 -819T/C and TA haplotype may be used as biomarkers for early detection of LC.
Keywords:	Head and neck cancer, Interleukin-10, laryngeal cancer, nasopharyngeal cancer, Tunisia
Être différent. Comment accompagner les indifférents
Authors: Meynier Olivier 
Published: January 2019

Les émotions vont et viennent se succédant ou s’entrechoquant : je me suis souvent senti incompris, asphyxié et en manque total de reconnaissance sans doute tel le papillon en gestation enfermé dans un cocon sombre et étroit, invisible, échappant aux regards… Quand l’explosion s’est produite, je suis sorti de la chrysalide et là, j’ai affronté les regards fuyants, moqueurs ou insistants… Mais j’ai réussi à sortir mes cartes et je me suis posé tranquillement sur un trèfle à quatre feuilles… Une dame de coeur m’a accueilli dans la paume de sa main, le regard doux et libérateur… J’ai ainsi arrêté de me cogner les ailes dans les coins du quatre de carreau et de me piquer les pattes sur les cactus. Maintenant je perçois ma différence d’être, papillon certes un peu écorché, mais bien vivant et affirmant mon envol même aux yeux des indifférents…
Sarabandes et virevoltes au « Gang Minute Papillon »
Authors: Juteau Anne , Guénoun Tamara , Latoch Marie , Abarcca Carolina , Minute Papillon CATTP 
Published: January 2019

Cet article vise à rendre compte collectivement de la singularité de ce travailà plusieurs, initié depuis un an au sein du cattp Minute Papillon. Les auteursprésentent au fil du texte les contours du projet de soin, orienté vers les prisesen charge sensori-motrices, artistiques et culturelles des enfants tsa, au seind’une équipe sanitaire pluridisciplinaire. Après avoir évoqué les références ayant inspiré ce cattp « ludique multi-lubique », une vignette clinique est exposéepour rendre palpable la complexité des parcours de soins des enfants accueilliset la nécessité, alors, de créer des dispositifs de soin à même de naviguer ausein de cette complexité pour y réintroduire du jeu et des capacités de liaisons psychiques, mises à mal par l’intensité des troubles de ces enfants. Pour finir, les auteurs donnent l’exemple du projet de danse, avec les perspectives qu’il ouvresur un travail à plusieurs, pluridisciplinaire, créatif avec les familles d’enfants tsa et ted .
Contestation et engagements adolescents
Authors: Nassikas Kostas 
Published: January 2019

L’auteur étudie ici les croisements entre la contestation, cette dimension fondamentale dans le processus de séparation-autonomisation adolescent, et l’engagement. Quand celui-ci recouvre l’angoisse de séparation, que contient la contestation, il pousse celle-ci vers les voies de la désocialisation et même de la radicalisation. Quand, au contraire, l’engagement investit des « objets internes », il peut contribuer à la réalisation des buts sociaux et sublimés.
Uveitis in Childhood
Authors: Kadayifçilar Sibel , Eldem Bora , Tumer Burak 
Published: January 2019

ABSTRACT
Purpose: To review the etiologic factors and complications of uveitis in patients younger than 16 years.
Patients and Methods: Between January 1989 and December 1999 in the Department of Ophthalmology of Hacettepe University School of Medicine, 219 patients were diagnosed or observed as having pediatric uveitis. After complete ocular and physical examinations, routine and specific laboratory and radiologic investigations were performed. Medical or surgical treatment was employed when necessary.
Results: Of the 219 patients, 112 were girls, with a mean age of 7.4 ± 4.2 years, and 107 were boys, with a mean age of 8.3 ± 3.4 years. In 24.2% of the cases, no etiologic factor could be ascertained; these cases comprised the idiopathic group. Among the remaining cases, the most common etiologies were toxoplasmosis, juvenile rheumatoid arthritis ORA), pars planitis, Behçet's disease, and Fuchs' heterochromic iridocyclitis. Anatomically, anterior uveitis was the most common form. The mean follow-up time was 37 ± 6.2 months. Complications for which surgical treatment was employed were identified in 71 eyes (20.9%), most of which were due to JRA, pars planitis, or Behçet's disease.
Conclusion: Uveitis in childhood may be idiopathic or most commonly due to toxoplasmosis, JRA, and pars planitis. Due to inflammation itself or to prolonged therapy especially with corticosteroids, pediatric uveitis entities (mostly JRA, pars planitis, or Behçet's disease) may result in complications necessitating a surgical approach.
J Pediatr Ophthalmol Strabismus 2003;40:335-340.
Oral Fluorescein Angiography in Patients With Choroidal Neovascularization and Macular Degeneration
Authors: Bartsch Dirk-Uwe , Elmusharaf Abbas , El-Bradey Mohamed , Freeman William R 
Published: January 2019

* OBJECTIVE: To evaluate image quality of oral fluorescein angiography in patients with age-related macular degeneration and choroidal neovascularization.
* MATERIALS AND METHODS: Twenty four patients with proven choroidal neovascularization were examined in a prospective observational case series. Confocal oral and intravenous fluorescein angiography were performed using the Heidelberg Retina Angiograph. Oral and intravenous image quality were compared in a masked fashion.
* RESULTS: Choroidal neovascularization could be diagnosed in all patients using intravenous angiograms. Oral fluorescein angiography accurately detected the presence or absence of choroidal neovascularization in all patients and could determine the classification of choroidal neovascularization, location, and extent and borders in 20 (83.3%) of 24 patients. Early, mid, and late phases of oral angiograms occurred at 8, 15, and 26 minutes, respectively.
* CONCLUSION: Oral fluorescein angiography using the confocal Heidelberg Retina Angiograph allowed detection of choroidal neovascularization in all patients in this study. Visualization of extent and type of choroidal neovascularization was possible in most eyes with choroidal neovascularization. These findings suggest oral angiography is an excellent screening tool for choroidal neovascularization and allows guidance of treatment in the majority of cases.
[Ophthalmic Surg Lasers Imaging 2003;34: 17-24]
Graphic Representation of Data Resulting From Measurement Comparison Trials in Cataract and Refractive Surgery
Authors: Krummenauer Frank , Storkebaum Kristin , Dick H Burkhard 
Published: January 2019

* BACKGROUND AND OBJECTIVES: The evaluation of new diagnostic measurement devices allows intraindividual comparison with an established standard method. However, reports in journal articles often omit the adequate incorporation of the intraindividual design into the graphic representation.
* PATIENTS AND METHODS: This article illustrates the drawbacks and the possible erroneous conclusions caused by this misleading practice in terms of recent method comparison data resulting from axial length measurement in 220 consecutive patients by both applanation ultrasound and partial coherence interferometry.
* RESULTS: Graphic representation of such method comparison data should be based on boxplots for intraindividual differences or on Bland-Altman plots. Otherwise, severe deviations between the measurement devices could be erroneously ignored and false-positive conclusions on the concordance of the instruments could result.
* CONCLUSION: Graphic representation of method comparison data should sensitively incorporate the underlying study design for intraindividual comparison.
[Ophthalmic Surg Lasers Imaging 2003;34:240-244.]
Visual Functions Following Recovery From Non-Arteritic Central Retinal Artery Occlusion
Authors: Landa Elina , Rehany Uri , Rumelt Shimon 
Published: January 2019

* BACKGROUND AND OBJECTIVE: Visual acuity and other visual functions may improve following treatment of central retinal artery occlusion (CRAO). A prospective, noncomparative case series study was conducted to investigate patients' visual functions after treatment of non-arteritic CRAO.
* PATIENTS AND METHODS: Eight consecutive patients whose visual acuity improved following successful systematic treatment protocol for non-arteritic CRAO of less than 48 hours (one of them with patent cilioretinal artery) were evaluated for visual functions. The visual acuity in seven patients ranged from no light perception to counting fingers at 3 feet on presentation and improved to 20/ 1 00 to 20/20 following treatment. The visual tests included: blue- yellow (Farnsworth D. 15) and green-red (pseudoisochromatic Ishihara color plates) color discrimination, contrast sensitivity, and visual fields. The patients were also evaluated for subjective daily function following treatment. All tests were also performed in the fellow uninvolved eye as a control.
* RESULTS: The visual acuity following treatment improved from no light perception to counting fingers at 3 feet to an average of 20/65 (range, 20/20 to 20/100). Despite this improvement, six patients had dyschromatopsia to blue, green, or red whereas only two patients with a final visual acuity of 20/20 preserved their ftill color discrimination. All patients had decreased contrast sensitivity at mid-spatial frequency (6 cycles/min) or a more generalized decrease and visual field defects. All of the patients except one were satisfied with the visual outcome and daily function after treatment.
* CONCLUSION: Despite improvement in visual acuity after treatment for CRAO, all patients had residual visual function abnormalities. These abnormalities may be attributed to partial recanalization, conversion of CRAO to multiple branch retinal artery occlusions, or different retinal susceptibility for ischemia.
[Ophthalmic Surg Lasers Imaging 2004;35:103-108.]
Indocyanine Green Angiography in High Myopia
Authors: Axer-Siegel Ruth , Cotlear Daniel , Priel Ethan , Rosenblatt Irit , Snir Moshe , Weinberger Dov 
Published: January 2019

* BACKGROUND AND OBJECTIVE: To evalu ate indocyanine green imaging of choroidal changes in pathologic myopia and to compare it with fluorescein angiography.
* PATIENTS AND METHODS: The angiograms of all consecutive patients with pathologic myopia photographed with confocal indocyanine green angiography using a scanning infrared laser or ophthalmoscope from March 1997 to December 1999 were reviewed.
* RESULTS: Twenty-one patients (35 eyes) were included. Indocyanine green angiography was performed in 35 eyes and immediate sequential fluorescein angiography and indocyanine green angiography in 25 eyes. The lacquer cracks were demonstrated to radiate from the disc, at the papillomacular bundle, through the macula, and around the macula. Lacquer cracks were identified in 89% and 28% of the eyes, respectively. Choroidal neovascularization (CNV) was demonstrated in 57% of eyes by indocyanine green angiography and in 56% by fluorescein angiography. All of the CNVs were classic and were located within 300 pm of the foveal center. Seventy percent of the CNVs were delineated in lacquer cracks by indocyanine green angiography. Overall, 124 lacquer cracks were identified by indocyanine green angiography and only 14 by fluorescein angiography. Lipids or serous detachment were not observed. Retinal hemorrhages were noted in 22% and 28% of eyes with indocyanine green angiography and fluorescein angiography, respectively.
* CONCLUSION: Confocal indocyanine green angiography offers better delineation of lacquer cracks and the localization of the CNV in lacquer cracks than does fluorescein angiography.
[Ophthalmic Surg Lasers Imaging 2004;35:139-145.]
White-Light and Laser Confocal Microscopic Findings of Rabbit Conjunctiva
Authors: Kobayashi Akira , Yoshita Tsuyoshi , Sugiyama Kazuhisa 
Published: January 2019

* BACKGROUND AND OBJECTIVE: To report laser and white-light confocal microscopic findings of ex vivo rabbit conjunctiva to investigate the potential application of these confocal microscopes as diagnostic devices for normal and pathologic conjunctiva.
* MATERIALS AND METHODS: Three male albino rabbits were killed and six eyeballs were removed with as much bulbar conjunctiva as possible. The bulbar conjunctiva approximately 5 mm away from the limbus was then subjected to an ex vivo laser and white-light confocal microscopic analysis.
* RESULTS: Using laser confocal microscopy, conjunctival epithelial cells, subepithelial conjunctival vessels, and sclera were clearly observed. By contrast, white-light confocal microscopy yielded images of conjunctival epithelium, subepithelial layers, and sclera that were not clearly defined.
* CONCLUSIONS: This study indicates that laser confocal microscopy has a superior ability to visualize ex vivo, non-fixed conjunctiva when compared with white-light confocal microscopy. It also suggests that the laser confocal microscope might be a useful, noninvasive, in vivo, "quasi-cytological" device for observing and diagnosing the conjunctival condition in humans.
[Ophthalmic Suig Lasers Imaging 2004;35:146-148.]
A New Surgical Approach for Indocyanine Green-Assisted Internal Limiting Membrane Peeling
Authors: Avci Remzi , Avci Berrin , Kaderli Berkant , Cavusoglu Ilkin 
Published: January 2019

* BACKGROUND AND OBJECTIVE: The efficiency of indocyanine green (ICG) dye in the removal of the internal limiting membrane (ILM) with a fluid needle using passive aspiration was evaluated.
* PATIENTS AND METHODS: Eighteen consecutive patients with diffuse diabetic macular edema were studied. After vitrectomy and total fluid- air exchange, 0. 1 mL of ICG solution 0.25% was left in the macular area for 1 minute. Then the macular ILM was peeled with a specially designed tapered fluid needle using passive aspiration.
* RESULTS: In 16 of the 18 eyes, the peeling procedure could be easily performed with a tapered fluid needle using passive aspiration. In 1 1 eyes, partial development of spontaneous ILM detachment prior to the peeling process was also observed.
* CONCLUSIONS: ICG solution 0.25% appears to reduce the adhesive force of the ILM to the sensory retina, which makes the removal of the ILM much easier by passive aspiration with a fluid needle.
[Ophthalmic Surg Lasers Imaging 2004;35:292-297.]
In Vivo Laser and White-Light Confocal Microscopic Findings of Human Conjunctiva
Authors: Kobayashi Akira , Yoshita Tsuyoshi , Sugiyama Kazuhisa 
Published: January 2019

* BACKGROUND AND OBJECTIVE: To report in vivo laser and white-light confocal microscopic findings of human conjunctiva to investigate the potential application of these confocal microscopes as diagnostic devices for normal and pathologic conjunctiva.
* PATIENTS AND METHODS: Two healthy volunteers, 28- and 35-year-old men, participated in this study. The temporal bulbar conjunctiva, which was approximately 5 mm away from the limbus, was examined by in vivo laser and white-light confocal microscopic analysis.
* RESULTS: Using laser confocal microscopy, at least two different cell types could be distinguished in both subjects: conjunctival superficial epithelial cells and conjunctival basal epithelial cells. In contrast, conjunctival epithelial cells could not be visualized using white-light confocal microscopy.
* CONCLUSIONS: These results indicate that laser confocal microscopy, but not white-light confocal microscopy, can be used to visualize in vivo human conjunctiva. Further investigations in a large number of normal subjects and in patients with conjunctival pathologies are required to fully evaluate the usefulness of this device in daily clinical ophthalmology.
[Ophthalmic Surg Lasers Imaging 2004;35:482-484.]
First World War Memorials in Slovakia
Authors: Zimová Katarína 
Published: January 2019

This survey focuses on Slovak cultural heritage and social memory, in particular First World War monuments in Slovakia. The description of historical circumstances provides a exemplary overview of memorials in Slovakia.
***
Članek se osredotoča na slovaško kulturno dediščino in družbeni spomin, zlasti na spomenike prve svetovne vojne na Slovaškem. Opisu zgodovinskih okoliščin sledi vzorčni pregled spomenikov na Slovaškem.
A tribute to Dr. Saul Hertz: The discovery of the medical uses of radioiodine
Authors: Hertz Barbara 
Published: January 2019

AbstractDr. Saul Hertz was Director of The Massachusetts General Hospital's Thyroid Unit, when he heard about the development of artificial radioactivity. He conceived and brought from bench to bedside the successful use of radioiodine (RAI) to diagnose and treat thyroid diseases. Thus was born the science of theragnostics used today for neuroendorine tumors and prostate cancer. Dr. Hertz's work set the foundation of targeted precision medicine.
Can we differentiate malignant peripheral nerve sheath tumor from benign neurofibroma without invasive sampling
Authors: Simsek Fikri Selcuk , Akarsu Saadet , Narin Yavuz 
Published: January 2019

AbstractOne of the most important benign tumors in neurofibromatosis type 1 (NF1) is plexiform neurofibroma, and there is a risk of developing malignant peripheral nerve sheath tumor (MPNST) throughout life approximately 10%. However lesion characterization by anatomical imaging methods are not possible. Because of that most of cases goes to biopsy. Using of fluorodeoxyglucose-positron emission tomography/computed tomography (FDG-PET/CT) for lesion characterization can be helpful in NF1 patients. We aimed to present an example of the efficacy of FDG-PET/CT in distinguishing benign neurofibroma from MPNST. A 6-year-old male patient who had NF1 admitted to emergency service due to high fever. Acute upper respiratory tract infection was diagnosed; antipyretic and abundant fluid intake was suggested. When high fever continued, the patient referred to our hospital on detection of axillary lymphadenopathy. Leukocytosis was detected in patient's blood count. Sedimentation was 54 mm/h, C-reactive protein 166 g/L, and lactate dehydrogenase 276U/L. Blood and throat cultures did not show pathogenic bacteria. In serological tests, VZV-IgG, EBV-VCA-IgG, and CMV-IgG were avidite positive; Hepatitis B Ag, Anti-HIV, Anti-HAV IgG and IgM, Anti-HCV, EBV-VCA IgM, and VZV-IgM were negative. Based on these results, cervical and thoracic contrast-enhanced computed tomography was performed on preliminary diagnosis of MPNST. Solid lesions with rounded margins, large one being 49 mm in size, that extend from superior mediastinum to posterior mediastinum, left axillary region, and left part of neck were detected, and they were surrounding the vascular structures. Since neurofibroma, MPNST, and lymphoma could not be distinguished, patient referred to FDG-PET/CT scanning. In FDG-PET/CT, highest lesion maximum standardized uptake value (SUVmax) was 1.5; SUVmaxlesion/SUVmaxliver 1.0, and SUVmax/ SUV mean liver 1.5. Biopsy from mediastinal and axillary region did not have LN structure and was positive for S-100 immunostaining, and patient was diagnosed as benign neurofibroma. We believe that there is no need for biopsy in lesions considered benign based on FDG-PET/CT parameters.
Sprengel's deformity as congenital scapular asymmetry on bone scintigraphy
Authors: Qutbi Mohsen 
Published: January 2019

AbstractBone scintigraphy is a valuable imaging modality for a diverse range of skeletal abnormalities. Incidental findings and congenital skeletal anomalies are not uncommonly encountered. Therefore, having a substantial knowledge of these findings, even rare ones, is essential for interpreting physicians. Here, we present a case of previously diagnosed malignancy referred for a bone scintigraphy for skeletal metastatic survey, in which Sprengel's deformity as congenital scapular asymmetry and cervicothoracic scoliosis was noted.
Ovarian cancer unmasked by technetium-99m bone scintigraphy and single-photon emission computed tomography-computed tomography
Authors: Verschueren Jolien , Huyghe Ivan , Van den Wyngaert Tim 
Published: January 2019

AbstractWe report a case of a 30-year-old female patient with a painless palpable nodule in the chest wall, evaluated for osseous involvement by technetium-99m (Tc-99m) bone scintigraphy. A whole-body scan revealed numerous sites of increased tracer accumulation throughout the thorax, abdomen, and pelvis. Subsequent single-photon emission computed tomography-computed tomography (SPECT-CT) of the abdomen and pelvis showed no abnormal uptake in the bone; however, significant nonosseous tracer accumulation in calcified soft tissue metastases was noted. Pathology confirmed a high-grade ovarian papillary serous adenocarcinoma. Extraosseous uptake of bone-seeking agents in the body is often incidental findings and can be explained by various benign and malignant conditions with soft tissue calcification. In our case report, this unusual finding on bone scintigraphy was highly suggestive for malignancy, initially not considered during the clinical evaluation of the patient. It also illustrates the usefulness of additional hybrid SPECT-CT to precisely localize extraosseous uptake of Tc-99m methylene diphoshonate.