bluuebunny/crossref_metadata_2025_split huggingface dataset:
Individual differences in non-adjacent statistical dependency learning in infants
Authors: LANY Jill , SHOAIB Amber 
Published: June 2019

AbstractThere is considerable controversy over the factors that shape infants’ developing knowledge of grammar. Work with artificial languages suggests that infants’ ability to track statistical regularities within the speech they hear could, in principle, support grammatical development. However, little work has tested whether infants’ performance on laboratory tasks reflects factors that are relevant in real-world language learning. Here we tested whether the language that infants hear at home, and their receptive language skills, predict their performance on tasks assessing the ability to learn non-adjacent statistical dependencies (NADs) at 15 months, and whether that in turn predicts sensitivity to native-language NADs at 18 months. We found evidence for some (though not all) of these relations, and primarily for females. The results suggest that performance on the artificial language-learning task reveals something about the mechanisms of grammatical development, and that females and males may be learning NADs differently.
Exploring the Value–Action Gap through Shared Values, Capabilities and Deforestation Behaviours in Guatemala
Authors: Robb Jane , Haggar Jeremy , Lamboll Richard , Castellanos Edwin 
Published: June 2019

SummaryUnderstanding drivers of deforestation is essential for developing any successful intervention to reduce forest degradation or loss, yet there remains relatively little consensus or clarity on how drivers should be identified and classified. To capture the full range of values and mediating factors that may contribute to land-use behaviours, an approach derived from a shared values perspective that includes a range of values associated with whole landscapes and ecosystems is required. We developed a model that combines behavioural theory with the Capability Approach as a conceptual framework through which to investigate the value–action gap. We used exploratory factor analysis (EFA) of Likert-scale responses to belief statements in order to identify land users’ shared values in the Sarstún Motagua region of Guatemala. We then qualify and quantify the role of capabilities in mediating between the shared values of different cultural groups of land users (Q’eqchi Maya and Ladinos) by comparing their factor scores with their self-reported forest cover change behaviours. Our results indicate that Maya and Ladinos share a set of values, but hold different value orientations that predict their behavioural intentions. We find that their different value orientations reflect behavioural intentions, but an understanding of the capabilities available to different groups is also necessary to fill the value–action gap. These findings have implications for behavioural theory, providing empirical links between shared values, capabilities and behaviour and identification of the role of value orientations, as well as demonstrating a useful approach for decision-makers seeking to understand drivers of change at landscape and whole-ecosystem levels.
A longitudinal study to investigate previousChlamydia trachomatisinfection as a risk factor for subsequent anorectal infection in men who have sex with men (MSM) and women visiting STI clinics in the Netherlands
Authors: Leenen J. , van Liere G.A.F.S. , Hoebe C.J.P.A. , Hogewoning A.A. , de Vries H.J.C. , Dukers-Muijrers N.H.T.M. 
Published: June 2019

AbstractAlthough anorectalChlamydia trachomatis(CT) infections are frequently diagnosed in men who have sex with men (MSM) and women, the reason for this infection often remains unexplained, as anal sex is not always reported. Oropharyngeal infections inoculating the gastrointestinal (GI) tract may contribute to anorectal-CT infections, as evidence in animals suggests that chlamydia bacteria undergo GI passage; however, no evidence exists in humans. Longitudinal patient clinic-registry data from MSM (n= 17 125) and women (n= 4120) from two Dutch sexually transmitted infection clinics were analysed. When adjusting for confounding socio-demographics, co-infections and risk behaviour, previous (from 3 weeks up to 24 months) oropharyngeal CT was not a risk factor for subsequent anorectal CT in women (odds ratio (OR) 0.46; 95% confidence interval (CI) 0.18–1.18;P= 0.11) and MSM (OR 1.33; 95% CI 0.86–2.07;P= 0.204). Despite the large dataset, the numbers did not allow for the estimation of risk in specific subgroups of interest. The role of the GI tract cannot be excluded with this epidemiological study, but the impact of preceding oropharyngeal CT on anorectal-CT infection is likely limited.
Processing level and diet quality of the US grocery cart: is there an association?
Authors: Juul Filippa , Simões Bárbara dos Santos , Litvak Jacqueline , Martinez-Steele Euridice , Deierlein Andrea , Vadiveloo Maya , Parekh Niyati 
Published: June 2019

AbstractObjective:The majority of groceries purchased by US households are industrially processed, yet it is unclear how processing level influences diet quality. We sought to determine if processing level is associated with diet quality of grocery purchases.Design:We analysed grocery purchasing data from the National Household Food Acquisition and Purchase Survey 2012–2013. Household grocery purchases were categorized by the NOVA framework as minimally processed, processed culinary ingredients, processed foods or ultra-processed foods. The energy share of each processing level (percentage of energy; %E) and Healthy Eating Index-2015 (HEI-2015) component and total scores were calculated for each household’s purchases. The association between %E from processed foods and ultra-processed foods, respectively, and HEI-2015 total score was determined by multivariable linear regression. Foods purchased by households with the highest v. lowest ultra-processed food purchases and HEI-2015 total score &lt;40 v. ≥60 were compared using linear regression.Setting:USA.Participants:Nationally representative sample of 3961 households.Results:Processed foods and ultra-processed foods provided 9·2 (se 0·3) % and 55·8 (se 0·6) % of purchased energy, respectively. Mean HEI-2015 score was 54·7 (se 0·4). Substituting 10 %E from minimally processed foods and processed culinary ingredients for ultra-processed foods decreased total HEI-2015 score by 1·8 points (β = −1·8; 95 % CI −2·0, −1·5). Processed food purchases were not associated with diet quality. Among households with high ultra-processed food purchases, those with HEI-2015 score &lt;40 purchased less minimally processed plant-foods than households with HEI-2015 score ≥60.Conclusions:Increasing purchases of minimally processed foods, decreasing purchases of ultra-processed foods and selecting healthier foods at each processing level may improve diet quality.
Reactive vs structural approach: A public law response to populism
Authors: ALTERIO ANA MICAELA 
Published: June 2019

Abstract:Contemporary scholarship mainly focuses on the crisis of political representation as the key facilitator behind the emergence of populism. If so, populism urges public law to revisit and rethink institutional designs. This article addresses two possible responses to populism. On one hand, an intuitive response could be to hamper popular participation by avoiding plebiscites, referendums or any other kind of public consultation. Alternatively, it is possible to respond to populism from a structural point of view. In my opinion, to resist populism public law should take into account the lack of responsiveness and accountability of representative systems. The article puts forward a proposal in that direction; it advances a response to populism consisting of new institutional systems that generate strong participatory mechanisms to incorporate ‘the popular’. In doing so, the article uses the new Latin American Constitutionalism as an example of both the potentialities and difficulties of designing institutional systems in public law. In the wake of rising populism, it contributes to the existing debate by criticising populism and its constitutional expression, as well as developing arguments in favour of popular constitutionalism.
Targeting IRAK4 disrupts inflammatory pathways and delays tumor development in chronic lymphocytic leukemia
Authors: Giménez Neus , Schulz Ralph , Higashi Morihiro , Aymerich Marta , Villamor Neus , Delgado Julio , Juan Manel , López-Guerra Mònica , Campo Elias , Rosich Laia , Seiffert Martina , Colomer Dolors 
Published: June 2019

AbstractInterleukin-1 receptor-associated kinase 4 (IRAK4) plays a critical role in Toll-like receptor (TLR) signal transduction and innate immune responses. Recruitment and subsequent activation of IRAK4 upon TLR stimulation is mediated by the myeloid differentiation primary response 88 (MYD88) adaptor protein. Around 3% of chronic lymphocytic leukemia (CLL) patients have activating mutations ofMYD88, a driver mutation in this disease. Here, we studied the effects of TLR activation and the pharmacological inhibition of IRAK4 with ND2158, an IRAK4 competitive inhibitor, as a therapeutic approach in CLL. Our in vitro studies demonstrated that ND2158 preferentially killed CLL cells in a dose-dependent manner. We further observed a decrease in NF-κB and STAT3 signaling, cytokine secretion, proliferation and migration of primary CLL cells fromMYD88-mutated and -unmutated cases. In theEµ-TCL1 adoptive transfer mouse model of CLL, ND2158 delayed tumor progression and modulated the activity of myeloid and T cells. Our findings show the importance of TLR signaling in CLL development and suggest IRAK4 as a therapeutic target for this disease.
Therapeutic effects of a novel BAFF blocker on arthritis
Authors: Zhou Bailing , Zhang Hailong , Su Xiaoqing , Luo Yi , Li Xiaopeng , Yu Chaoheng , Xie Qibing , Xia Xuyang , He Gu , Yang Li 
Published: June 2019

AbstractB-cell targeted therapy is effective for autoimmune diseases such as systemic lupus erythematosus and rheumatoid arthritis (RA), although there are setbacks in RA clinical trials. In this study, we designed a novel B-cell activating factor (BAFF) antagonist: BAFF-Trap, a recombinant glycoprotein with BAFF-binding domains of two BAFF receptors (TACI and Br3) linked to Fc domain of human IgG1. Unlike TACI-Fc, BAFF-Trap bound BAFF but not APRIL (a proliferation-inducing ligand), and significantly suppressed the development of collagen-induced arthritis and adjuvant-induced arthritis. Furthermore, BAFF-Trap inhibited proinflammatory cytokine expression, ameliorated joint damage and suppressed B- and T-cell activation. BAFF-Trap reduced dendritic cells in joints, and increased regulatory T cell, regulatory B-cell, and M2 macrophage. The function of BAFF-Trap was related to inhibition of canonical and noncanonical NF-κB activation. Thus, BAFF-Trap may be a valuable agent for the effective treatment of RA.
Modeling microcephaly with cerebral organoids reveals a WDR62–CEP170–KIF2A pathway promoting cilium disassembly in neural progenitors
Authors: Zhang Wei , Yang Si-Lu , Yang Mei , Herrlinger Stephanie , Shao Qiang , Collar John L. , Fierro Edgar , Shi Yanhong , Liu Aimin , Lu Hui , Herring Bruce E. , Guo Ming-Lei , Buch Shilpa , Zhao Zhen , Xu Jian , Lu Zhipeng , Chen Jian-Fu 
Published: June 2019

AbstractPrimary microcephaly is caused by mutations in genes encoding centrosomal proteins including WDR62 and KIF2A. However, mechanisms underlying human microcephaly remain elusive. By creating mutant mice and human cerebral organoids, here we found that WDR62 deletion resulted in a reduction in the size of mouse brains and organoids due to the disruption of neural progenitor cells (NPCs), including outer radial glia (oRG). WDR62 ablation led to retarded cilium disassembly, long cilium, and delayed cell cycle progression leading to decreased proliferation and premature differentiation of NPCs. Mechanistically, WDR62 interacts with and promotes CEP170’s localization to the basal body of primary cilium, where CEP170 recruits microtubule-depolymerizing factor KIF2A to disassemble cilium. WDR62 depletion reduced KIF2A’s basal body localization, and enhanced KIF2A expression partially rescued deficits in cilium length and NPC proliferation. Thus, modeling microcephaly with cerebral organoids and mice reveals a WDR62-CEP170-KIF2A pathway promoting cilium disassembly, disruption of which contributes to microcephaly.
Layer-specific integration of locomotion and sensory information in mouse barrel cortex
Authors: Ayaz Aslı , Stäuble Andreas , Hamada Morio , Wulf Marie-Angela , Saleem Aman B. , Helmchen Fritjof 
Published: June 2019

AbstractDuring navigation, rodents continually sample the environment with their whiskers. How locomotion modulates neuronal activity in somatosensory cortex, and how it is integrated with whisker-touch remains unclear. Here, we compared neuronal activity in layer 2/3 (L2/3) and L5 of barrel cortex using calcium imaging in mice running in a tactile virtual reality. Both layers increase their activity during running and concomitant whisking, in the absence of touch. Fewer neurons are modulated by whisking alone. Whereas L5 neurons respond transiently to wall-touch during running, L2/3 neurons show sustained activity. Consistently, neurons encoding running-with-touch are more abundant in L2/3 and they encode the run-speed better during touch. Few neurons across layers were also sensitive to abrupt perturbations of tactile flow during running. In summary, locomotion significantly enhances barrel cortex activity across layers with L5 neurons mainly reporting changes in touch conditions and L2/3 neurons continually integrating tactile stimuli with running.
Atomic-resolution imaging of surface and core melting in individual size-selected Au nanoclusters on carbon
Authors: Foster D. M. , Pavloudis Th. , Kioseoglou J. , Palmer R. E. 
Published: June 2019

AbstractAlthough the changes in melting behaviour on the nanoscale have long attracted the interest of researchers, the mechanism by which nanoparticles melt remains an open problem. We report the direct observation, at atomic resolution, of surface melting in individual size-selected Au clusters (2–5 nm diameter) supported on carbon films, using an in situ heating stage in the aberration corrected scanning transmission electron microscope. At elevated temperatures the Au nanoparticles are found to form a solid core-liquid shell structure. The cluster surface melting temperatures, show evidence of size-dependent melting point suppression. The cluster core melting temperatures are significantly greater than predicted by existing models of free clusters. To explore the effect of the interaction between the clusters and the carbon substrate, we employ a very large-scale ab initio simulation approach to investigate the influence of the support. Theoretical results for surface and core melting points are in good agreement with experiment.
Deep data analytics for genetic engineering of diatoms linking genotype to phenotype via machine learning
Authors: Trofimov Artem A. , Pawlicki Alison A. , Borodinov Nikolay , Mandal Shovon , Mathews Teresa J. , Hildebrand Mark , Ziatdinov Maxim A. , Hausladen Katherine A. , Urbanowicz Paulina K. , Steed Chad A. , Ievlev Anton V. , Belianinov Alex , Michener Joshua K. , Vasudevan Rama , Ovchinnikova Olga S. 
Published: June 2019

AbstractGenome engineering for materials synthesis is a promising avenue for manufacturing materials with unique properties under ambient conditions. Biomineralization in diatoms, unicellular algae that use silica to construct micron-scale cell walls with nanoscale features, is an attractive candidate for functional synthesis of materials for applications including photonics, sensing, filtration, and drug delivery. Therefore, controllably modifying diatom structure through targeted genetic modifications for these applications is a very promising field. In this work, we used gene knockdown in Thalassiosira pseudonana diatoms to create modified strains with changes to structural morphology and linked genotype to phenotype using supervised machine learning. An artificial neural network (NN) was developed to distinguish wild and modified diatoms based on the SEM images of frustules exhibiting phenotypic changes caused by a specific protein (Thaps3_21880), resulting in 94% detection accuracy. Class activation maps visualized physical changes that allowed the NNs to separate diatom strains, subsequently establishing a specific gene that controls pores. A further NN was created to batch process image data, automatically recognize pores, and extract pore-related parameters. Class interrelationship of the extracted paraments was visualized using a multivariate data visualization tool, called CrossVis, and allowed to directly link changes in morphological diatom phenotype of pore size and distribution with changes in the genotype.
Supplying a pharmacy for NASA exploration spaceflight: challenges and current understanding
Authors: Blue Rebecca S. , Bayuse Tina M. , Daniels Vernie R. , Wotring Virginia E. , Suresh Rahul , Mulcahy Robert A. , Antonsen Erik L. 
Published: June 2019

AbstractIn order to maintain crew health and performance during long-duration spaceflight outside of low-Earth orbit, NASA and its international partners must be capable of providing a safe and effective pharmacy. Given few directed studies of pharmaceuticals in the space environment, it is difficult to characterize pharmaceutical effectiveness or stability during spaceflight; this in turn makes it challenging to select an appropriate formulary for exploration. Here, we present the current state of literature regarding pharmaceutical stability, metabolism, and effectiveness during spaceflight. In particular, we have attempted to highlight the gaps in current knowledge and the difficulties in translating terrestrial-based drug studies to a meaningful interpretation of drug stability, safety, and effectiveness in space. We hope to identify high-yield opportunities for future research that might better define and mitigate pharmaceutical risk for exploration missions.
Spending at least 120 minutes a week in nature is associated with good health and wellbeing
Authors: White Mathew P. , Alcock Ian , Grellier James , Wheeler Benedict W. , Hartig Terry , Warber Sara L. , Bone Angie , Depledge Michael H. , Fleming Lora E. 
Published: June 2019

AbstractSpending time in natural environments can benefit health and well-being, but exposure-response relationships are under-researched. We examined associations between recreational nature contact in the last seven days and self-reported health and well-being. Participants (n = 19,806) were drawn from the Monitor of Engagement with the Natural Environment Survey (2014/15–2015/16); weighted to be nationally representative. Weekly contact was categorised using 60 min blocks. Analyses controlled for residential greenspace and other neighbourhood and individual factors. Compared to no nature contact last week, the likelihood of reporting good health or high well-being became significantly greater with contact ≥120 mins (e.g. 120–179 mins: ORs [95%CIs]: Health = 1.59 [1.31–1.92]; Well-being = 1.23 [1.08–1.40]). Positive associations peaked between 200–300 mins per week with no further gain. The pattern was consistent across key groups including older adults and those with long-term health issues. It did not matter how 120 mins of contact a week was achieved (e.g. one long vs. several shorter visits/week). Prospective longitudinal and intervention studies are a critical next step in developing possible weekly nature exposure guidelines comparable to those for physical activity.
Effects of maize rotation on the physicochemical properties and microbial communities of American ginseng cultivated soil
Authors: Jiao Xiao-Lin , Zhang Xue-Song , Lu Xiao-Hong , Qin Ruijun , Bi Yan-Meng , Gao Wei-Wei 
Published: June 2019

AbstractThe production of American ginseng (Panax quinquefolius L.) is severely limited by the replant disorders in China. Crop rotation with maize might reduce the replant problems, but little information is available on the effect of maize rotation on soil cultivated with ginseng. In this study, we analyzed nutrients, phenolic acids, and microbial communities in soils from the fields with continuous maize, mono-culture ginseng, and 1-, 3-, and 5-year maize rotation after ginseng. Pot experiments were also conducted to evaluate the performance of replanting ginseng in these soils. The results showed that Mn, Cu, and 5 phenolic acids in ginseng-cultivated soil were significantly decreased by maize rotation. A 5-year maize rotation significantly increased the relative abundance of beneficial soil bacteria, such as Arthrobacter, rather than decreasing the abundances of potential pathogenic genera. Clustering analysis revealed that the physicochemical properties and microbial communities of 3- and 5-year maize rotation soil were more similar to CM than to G soil. The biomass of replanted ginseng root was improved, and root disease was reduced over 3 years of maize rotation. Overall, the results showed that at least a 3-year maize rotation is needed to overcome the replant failure of American ginseng.
Precisely Endowing Colloidal Particles with Silica Branches
Authors: Zhao Bin , Li Dongzhi , Long Yue , Song Kai 
Published: June 2019

AbstractA method to modify colloidal particles with silica rods in a water/n-pentanol system is reported here. Because of the interfacial tension between aqueous and n-pentanol phase, water which surrounds the colloidal particles de-wets into droplets during the deposition process of silica. As a result of unidirectional deposition, silica rods grow perpendicularly on the surface of the colloidal particles at the site of the smallest curvature where the water droplet has been de-wetted. By controlling the hydrolysis conditions, particles with certain number of branches or rambutan-like particles can be obtained. This approach opens a path towards the higher levels of colloidal complexity.
The purinergic receptor antagonist oxidized adenosine triphosphate suppresses immune-mediated corneal allograft rejection
Authors: Foulsham William , Mittal Sharad K. , Nakao Takeshi , Coco Giulia , Taketani Yukako , Chauhan Sunil K. , Dana Reza 
Published: June 2019

AbstractAdenosine triphosphate (ATP) is released into the extracellular environment during transplantation, and acts via purinergic receptors to amplify the alloimmune response. Here, using a well-established murine model of allogeneic corneal transplantation, we investigated the immunomodulatory mechanisms of the purinergic receptor antagonist oxidized ATP (oATP). Corneal transplantation was performed using C57BL/6 donors and BALB/c hosts. oATP or sterile saline was administered via intraperitoneal injection for 2 weeks postoperatively. Frequencies of CD45+ leukocytes, CD11b+MHCII+ antigen presenting cells (APCs), CD4+IFN-γ+ effector Th1 cells and CD4+Foxp3+ regulatory T cells (Tregs) were evaluated by flow cytometry. Slit-lamp microscopy was performed weekly for 8 weeks to evaluate graft opacity and determine transplant rejection. Treatment with oATP was shown to significantly reduce graft infiltration of CD45+ leukocytes, decrease APC maturation and suppress effector Th1 cell generation relative to saline-treated control. No difference in Treg frequencies or Foxp3 expression was observed between the oATP-treated and control groups. Finally, oATP treatment was shown to reduce graft opacity and increase graft survival. This report demonstrates that oATP limits the alloimmune response by regulating APC maturation and suppressing the generation of alloreactive Th1 immunity.