bluuebunny/crossref_metadata_2025_split huggingface dataset:
Lower DHEA-S levels predict disease and worse outcomes in post-menopausal women with idiopathic, connective tissue disease- and congenital heart disease-associated pulmonary arterial hypertension
Authors: Baird Grayson L. , Archer-Chicko Christine , Barr R. Graham , Bluemke David A. , Foderaro Andrew E. , Fritz Jason S. , Hill Nicholas S. , Kawut Steven M. , Klinger James R. , Lima Joao A.C. , Mullin Christopher J. , Ouyang Pamela , Palevsky Harold I. , Palmisicano Amy J. , Pinder Diane , Preston Ioana R. , Roberts Kari E. , Smith K. Akaya , Walsh Thomas , Whittenhall Mary , Ventetuolo Corey E. 
Published: June 2018

High oestradiol (E2) and low dehydroepiandrosterone-sulfate (DHEA-S) levels are risk factors for pulmonary arterial hypertension (PAH) in men, but whether sex hormones are related to PAH in women is unknown.Post-menopausal women aged ≥55 years with PAH were matched by age and body mass index to women without cardiovascular disease. Plasma sex hormone levels were measured by immunoassay.Lower levels of DHEA-S (p<0.001) and higher levels of E2 (p=0.02) were associated with PAH. In PAH cases (n=112), lower DHEA-S levels were associated with worse haemodynamics (all p<0.01) and more right ventricular dilatation and dysfunction (both p=0.001). Lower DHEA-S levels were associated with shorter 6-min walking distance (6MWD) (p=0.01) and worse functional class (p=0.004). Each Ln(1 µg·dL−1) decrease in DHEA-S was associated with a doubling in the risk of death (hazard ratio 2.0, 95% CI 1.5–2.7; p<0.001). Higher levels of E2 were associated with shorter 6MWD (p=0.03) and worse functional class (p=0.01).High E2 and low DHEA-S levels are associated with the risk and severity of PAH in post-menopausal women. Hormonal modulation should be studied as a treatment strategy in PAH.
Clozapine rapid retitration in the community: an assertive approach can prevent admissions
Authors: Nikolić Nikola , Kilbride Kevin , Preston Patrick 
Published: June 2018

SUMMARYRapid retitration of clozapine may be necessary to reduce the known high risk of mental state destabilisation in patients who have had a 48 h treatment break. It may carry a high risk of complications, including seizures and myocarditis. We reflect on the literature on standard and rapid retitration and present a case of rapid retitration in the community. In this case, of a 54-year-old homeless man with treatment-resistant schizophrenia and polysubstance misuse, we safely retitrated clozapine in a community setting four times during a 6-month period; each retitration was completed over 4 days. We used a specific protocol based on his psychiatric history. We are now more confident in delivering clozapine retitration to other patients, thus preventing unnecessary admissions.DECLARATION OF INTERESTN. N. has received honoraria from Janssen Pharmaceuticals.
Chat- and internet-based cognitive–behavioural therapy in treatment of adolescent depression: randomised controlled trial
Authors: Topooco Naira , Berg Matilda , Johansson Sofie , Liljethörn Lina , Radvogin Ella , Vlaescu George , Nordgren Lise Bergman , Zetterqvist Maria , Andersson Gerhard 
Published: June 2018

BackgroundDepression is a major contributor to the burden of disease in the adolescent population. Internet-based interventions can increase access to treatment.AimsTo evaluate the efficacy of internet-based cognitive–behavioural therapy (iCBT), including therapist chat communication, in treatment of adolescent depression.MethodSeventy adolescents, 15–19 years of age and presenting with depressive symptoms, were randomised to iCBT or attention control. The primary outcome was the Beck Depression Inventory II (BDI-II).ResultsSignificant reductions in depressive symptoms were found, favouring iCBT over the control condition (F(1,67) = 6.18, P < 0.05). The between-group effect size was Cohen's d = 0.71 (95% CI 0.22–1.19). A significantly higher proportion of iCBT participants (42.4%) than controls (13.5%) showed a 50% decrease in BDI-II score post-treatment (P < 0.01). The improvement for the iCBT group was maintained at 6 months.ConclusionsThe intervention appears to effectively reduce symptoms of depression in adolescents and may be helpful in overcoming barriers to care among young people.Declaration of interestN.T. and G.A. designed the programme. N.T. authored the treatment material. The web platform used for treatment is owned by Linköping University and run on a non-for-profit basis. None of the authors receives any income from the programme.
Potent Inactivation-Dependent Inhibition of Adult and Neonatal NaV1.5 Channels by Lidocaine and Levobupivacaine
Authors: Elajnaf Taha , Baptista-Hon Daniel T. , Hales Tim G. 
Published: June 2018

BACKGROUND:
Cardiotoxic effects of local anesthetics (LAs) involve inhibition of NaV1.5 voltage-gated Na+ channels. Metastatic breast and colon cancer cells also express NaV1.5, predominantly the neonatal splice variant (nNaV1.5) and their inhibition by LAs reduces invasion and migration. It may be advantageous to target cancer cells while sparing cardiac function through selective blockade of nNaV1.5 and/or by preferentially affecting inactivated NaV1.5, which predominate in cancer cells. We tested the hypotheses that lidocaine and levobupivacaine differentially affect (1) adult (aNaV1.5) and nNaV1.5 and (2) the resting and inactivated states of NaV1.5.

METHODS:
The whole-cell voltage-clamp technique was used to evaluate the actions of lidocaine and levobupivacaine on recombinant NaV1.5 channels expressed in HEK-293 cells. Cells were transiently transfected with cDNAs encoding either aNaV1.5 or nNaV1.5. Voltage protocols were applied to determine depolarizing potentials that either activated or inactivated 50% of maximum conductance (V½ activation and V½ inactivation, respectively).

RESULTS:
Lidocaine and levobupivacaine potently inhibited aNaV1.5 (IC50 mean [SD]: 20 [22] and 1 [0.6] μM, respectively) and nNaV1.5 (IC50 mean [SD]: 17 [10] and 3 [1.6] μM, respectively) at a holding potential of −80 mV. IC50s differed significantly between lidocaine and levobupivacaine with no influence of splice variant. Levobupivacaine induced a statistically significant depolarizing shift in the V½ activation for aNaV1.5 (mean [SD] from −32 [4.6] mV to −26 [8.1] mV) but had no effect on the voltage dependence of activation of nNaV1.5. Lidocaine had no effect on V½ activation of either variant but caused a significantly greater depression of maximum current mediated by nNaV1.5 compared to aNaV1.5. Similar statistically significant shifts in the V½ inactivation (approximately −10 mV) occurred for both LAs and NaV1.5 variants. Levobupivacaine (1 μM) caused a significantly greater slowing of recovery from inactivation of both variants than did lidocaine (10 μM). Both LAs caused approximately 50% tonic inhibition of aNaV1.5 or nNaV1.5 when holding at −80 mV. Neither LA caused tonic block at a holding potential of either −90 or −120 mV, voltages at which there was little steady-state inactivation. Higher concentrations of either lidocaine (300 μM) or levobupivacaine (100 μM) caused significantly more tonic block at −120 mV.

CONCLUSIONS:
These data demonstrate that low concentrations of the LAs exhibit inactivation-dependent block of NaV1.5, which may provide a rationale for their use to safely inhibit migration and invasion by metastatic cancer cells without cardiotoxicity.
Case Report: Severe back pain, epigastric distress and refractory nausea; an unusual presentation of mediastinal bronchogenic cyst
Authors: Ali Saeed , Rauf Abdul , Meng Ling Bing , Sattar Zeeshan , Hussain Sana , Majeed Umair 
Published: June 2018

Background: Bronchogenic cysts are congenital malformations from abnormal budding of embryonic foregut and tracheobronchial tree. We present a case of bronchogenic cyst with severe back pain, epigastric distress and refractory nausea and vomiting. Case Presentation: A 44-year-old Hispanic female presented with a 3-week history of recurrent sharp interscapular pain radiating to epigastrium with refractory nausea and vomiting. She underwent cholecystectomy 2-years ago. Computed tomography (CT) abdomen at that time showed a subcarinal mass measuring 5.4 X 5.0 cm. Subsequent endoscopic ultrasound diagnosed it as a bronchogenic cyst. Endobronchial ultrasound (EBUS) guided aspiration resulted in incomplete drainage and she was discharged after partial improvement. Current physical examination showed tachycardia and tachypnea with labs showing leukocytosis, elevated inflammatory markers, and hypokalemic metabolic alkalosis. CT chest showed an increased size of the bronchogenic cyst (9.64 X 7.7 cm) suggestive of possible partial cyst rupture or infected cyst. X-ray esophagram ruled out esophageal compression or contrast extravasation. Patient’s symptoms were refractory to conservative management. The patient ultimately underwent right thoracotomy with cyst excision that resulted in complete resolution of symptoms. Conclusion: Bronchogenic cysts are the most common primary cysts of mediastinum with the prevalence of 6%. The most common symptoms are chest pain, dyspnea, cough, and stridor. Diagnosis is made by chest X-Ray and CT chest. Magnetic resonance imaging chest and EBUS are more sensitive and specific. Symptomatic cysts should be resected unless surgical risks are high. Asymptomatic cysts in younger patients should be removed due to low surgical risk and potential late complications. Watchful waiting has been recommended for asymptomatic adults or high-risk patients. This case presents mediastinal bronchogenic cyst as a cause of back, nausea and refractory vomiting. Immediate surgical excision in such cases should be attempted, which will lead to resolution of symptoms and avoidance of complications.
Linguistique et littérature en dialogue / Linguística e Literatura em diálogo - entretien avec / entrevista com Roger Chartier
Authors: Araújo Everaldo Lima de , Silva Jefferson Evaristo do Nascimento , Lenhardt Jordana , Felipe Márcia Da Gama Silva 
Published: June 2018

Roger Chartier, docteur par l'École Normale Supérieure de Saint-Cloud (France), est un influent historien, chercheur à l'École des Hautes Études en Sciences Sociales et professeur honoraire au Collège de France. Il a des recherches dans le domaine de l'histoire de la culture et des livres, de la trajectoire de la lecture et de l'écrit en tant que pratiques sociales. Ses études sur l'Histoire du Livre et de la Lecture en Europe sont particulièrement remarquables. Il a également publié une vaste production, y compris Lecture et lecteurs dans la France de l'Ancien Régime (1987), Les origines culturelles de la Révolution Française (1990), Escribir las prácticas. Foucault, De Certeau, Marin (1996), Écrire et effacer: culture écrite et littérature (2003), entre autres, et a co-dirigé Histoire de l'édition française (1983-1986) et Histoire de la lecture dans le monde occidental (1997).Roger Chartier, doutor pela École Normale Supérieure de Saint-Cloud (França), é um influente historiador, pesquisador da École des Hautes Études en Sciences Sociales e professor honorário do Collège de France. Possui investigação no campo da história da cultura e dos livros, da trajetória da leitura e da escrita como práticas sociais. Destacam-se sobretudo os seus estudos sobre a História do Livro e da Leitura na Europa. Possui ainda vastíssima produção publicada, das quais se destacam Lecture et lecteurs dans la France de l’Ancien Régime (1987), Les origines culturelles de la Révolution Française (1990), Escribir las prácticas. Foucault, De Certeau, Marin (1996), Écrire et effacer: culture écrite et littérature (2003), entre outros, e codirigiu Histoire de l’édition française (1983–1986) e Histoire de la lecture dans le monde occidental (1997).
Can patient-specific finite element models better predict fractures in metastatic bone disease than experienced clinicians?
Authors: Eggermont F. , Derikx L. C. , Verdonschot N. , van der Geest I. C. M. , de Jong M. A. A. , Snyers A. , van der Linden Y. M. , Tanck E. 
Published: June 2018

Objectives In this prospective cohort study, we investigated whether patient-specific finite element (FE) models can identify patients at risk of a pathological femoral fracture resulting from metastatic bone disease, and compared these FE predictions with clinical assessments by experienced clinicians. Methods A total of 39 patients with non-fractured femoral metastatic lesions who were irradiated for pain were included from three radiotherapy institutes. During follow-up, nine pathological fractures occurred in seven patients. Quantitative CT-based FE models were generated for all patients. Femoral failure load was calculated and compared between the fractured and non-fractured femurs. Due to inter-scanner differences, patients were analyzed separately for the three institutes. In addition, the FE-based predictions were compared with fracture risk assessments by experienced clinicians. Results In institute 1, median failure load was significantly lower for patients who sustained a fracture than for patients with no fractures. In institutes 2 and 3, the number of patients with a fracture was too low to make a clear distinction. Fracture locations were well predicted by the FE model when compared with post-fracture radiographs. The FE model was more accurate in identifying patients with a high fracture risk compared with experienced clinicians, with a sensitivity of 89% versus 0% to 33% for clinical assessments. Specificity was 79% for the FE models versus 84% to 95% for clinical assessments. Conclusion FE models can be a valuable tool to improve clinical fracture risk predictions in metastatic bone disease. Future work in a larger patient population should confirm the higher predictive power of FE models compared with current clinical guidelines. Cite this article: F. Eggermont, L. C. Derikx, N. Verdonschot, I. C. M. van der Geest, M. A. A. de Jong, A. Snyers, Y. M. van der Linden, E. Tanck. Can patient-specific finite element models better predict fractures in metastatic bone disease than experienced clinicians? Towards computational modelling in daily clinical practice. Bone Joint Res 2018;7:430–439. DOI: 10.1302/2046-3758.76.BJR-2017-0325.R2.
Accommodating the third space in a fourth society: BDAFRICA, a groundbreaking source for the analysis of African literature reception in Spain
Authors: Fernández Ruiz María Remedios , Corpas Pastor Gloria , Seghiri Míriam 
Published: June 2018

Abstract
Inherent features of African postcolonial literature have hampered reception quantification, which is even more often neglected in countries with limited experience of African decolonization processes. This has been exemplified through the Spanish case, where there was no quantitative data available to report on current reception trends. Hence, by exploiting the BDAFRICA database, a relevant specialized bibliographical research tool, we have provided an unparalleled study that covers 42 years of African literature reception in Spain (1972–2014). The methods described in this paper are descriptive. Quantitative information that is subject to a descriptive analysis has been selected from BDAFRICA. The results provide clear evidence of the sustained increase in the production of African fiction books and offer academia unparalleled data, thereby opening the door to manifold research lines.
Imperativo categórico y kairós en la ética de Husserl
Authors: Walton Roberto J. 
Published: June 2018

El propósito de este artículo es analizar tanto el lado que se orienta al campo de posibilidades como el lado que se dirige al momento de una acción particular en la formulación husserliana del imperativo categórico: “¡Haz en todo momento lo mejor entre lo alcanzable!” En primer lugar, el autor examina el alcance de las posibilidades que Husserl considera a fin de delinear el mejor curso de acción. Este análisis desemboca en una doble ampliación del horizonte práctico. Por un lado, un horizonte personal de vida implica tanto una habitualidad o estilo unitario como una decisión que elige una profesión o vocación; por el otro, un horizonte intersubjetivo implica el logro de una comunidad del amor como la más alta forma de comunidad.
En segundo lugar, el artículo explora la evolución del imperativo categórico con el objeto de subrayar su subordinación a los valores del amor y su orientación teleológica hacia una realización más perfecta de lo que solo ha sido alcanzado parcialmente. Se sostiene que, mientras la determinación en el horizonte de posibilidades prácticas lleva al examen de la mejor acción posible dentro de una esfera limitada, la indeterminación motiva la mejor aproximación posible a un ideal teleológico. Por último, se analiza el momento de una acción particular a fin de mostrar cómo la noción de kairós desempeña un papel en diferentes estadios en el desenvolvimiento del imperativo categórico que encierran un momento crítico de oportunidad.
El argumento de la simplicidad y los conceptos de espacio y tiempo en Samuel Clarke
Authors: Benítez Grobert Laura 
Published: June 2018

La autora de este estudio se propone poner de relieve la importancia del argumento de la simplicidad en el desarrollo de las ideas de espacio y tiempo en Samuel Clarke y su incidencia en el newtonianismo. Así, en primer lugar intenta poner al descubierto la importancia que la noción de simplicidad tiene para el dualismo de Samuel Clarke, en donde se ponen en conexión la extensión y la simplicidad cuando se considera que la inmensidad de Dios es extensión indivisa. Por otra parte, recorre las vicisitudes del argumento de la simplicidad en función de las nociones físicas de espacio y de tiempo, para concluir que los simples de Clarke (espacio y tiempo) son muy cercanos a los conceptos de espacio y tiempo absolutos en Newton.
Finalmente se explica cómo en opinión de Clarke el alma humana, siendo una sustancia simple y, por tanto, indivisible, es sin embargo una sustancia extensa; en este caso las partes, como las concibe Clarke, no son burdas y diferenciadas, sino semejantes e inseparables, algo que Leibniz habría reducido a una única entidad, en vista de su argumento de la identidad de los indiscernibles.
Sobre la posible "superación" de la epistemología
Authors: Candioti de De Zan María Elena 
Published: June 2018

Se analiza la situación actual de la epistemología y aquellas críticas -tales como las de Rorty y Taylor- que indican la necesidad de su superación. El trabajo se propone mostrar que el proyecto fundacionista y las ideas de representación exacta, de experiencia elemental e incorregibilidad -que desde la modernidad condicionaron la epistemología- son insostenibles. Sin embargo, puede pensarse una forma nueva de reflexión filosófica que considere la trama conocimiento / lenguaje/ acción. Esta nueva perspectiva implica atender a los múltiples juegos de lenguaje en los que puede darse el conocimiento, y configurar el campo epistemológico desde otros interrogantes. AbstractThe aim of this work is to analyze the current situation of epistemology, and those critics, such as those presented by Rorty and Taylor, that indicate the necessity of overcoming. It is intended to show that the foundational project and ideas of exact representation, elementary experience and incorrigibility, which from modernity conditioned epistemology, are untenable. However, a new form of philosophical reflection that considers the plot knowledge / language / action, can be thought. This new perspective implicates to attend to the multiples games of language in which knowledge can be taken configurating the epistemological field from other interrogations.
Pertumbuhan Kepiting Bakau (Scylla serrata Forsskål, 1775) dengan Ukuran Pakan Berbeda pada Budidaya dengan Sistem Baterai
Authors: Djunaedi Ali , Sunaryo Sunaryo , Aditya Bagus Pitra 
Published: June 2018

Kepiting bakau (S. serrata Forsskål, 1775) merupakan salah satu sumber daya perikanan bernilai ekonomis tinggi dan potensial untuk dibudidayakan. Pakan adalah faktor produksi yang penting dalam budidaya kepiting bakau. Tujuan dari penelitian ini adalah untuk mengetahui pengaruh pemberian pelet yang berbeda ukuran bagi pertumbuhan kepiting bakau (S. serrata Forsskål, 1775). Metode penelitian ini menggunakkan Rancangan Acak Lengkap (RAL) dengan 3 perlakuan dan 10 kali ulangan pada masing-masing perlakuan, yaitu: perlakuan A (diameter pelet + 10 mm), perlakuan B (diameter pelet + 5 mm) dan perlakuan C (diameter pelet + 1 mm). Data laju pertumbuhan spesifik (SGR) dianalisis dengan Anova. Hasil penelitian menunjukkan bahwa perlakuan pemberian pelet yang berbeda ukuran berpengaruh sangat nyata (p<0,01) terhadap Laju Pertumbuhan Spesifik (SGR), Rasio Konversi Pakan (FCR) dan Rasio Efisiensi Protein (PER). Hal tersebut menunjukkan bahwa ukuran pellet sangat menentukan pertumbuhan Kepiting Bakau (S. serrata Forsskål, 1775).Kata Kunci : Ukuran Pelet, Kepiting Bakau (S. serrata Forsskål, 1775), Laju Pertumbuhan Spesifik (SGR) Mud crab (S. serrata Forsskål, 1775) is one of the fisheries resources that has high economic value and potential to be cultivated. Feed is one of important production factors on the mud crab farming. The purpose of this study is investigated the effect of different sizes pellets on the growth of mud crab (S. serrata Forsskål, 1775). The research method in this study was used experimental laboratory with completely randomized design (CRD) with 3 treatments and 10 replications in each treatment. Specific growthrate (SGR) data was analyzed with anova. These results indicate that administration of treatment different size pellets effect is very significant (p<0,01) on Specifik Growthrate (SGR), Feed Conversion Ratio (FCR) and Protein Efiecient Ratio (PER). Its that suggest that pellet size affect on the growthrate of the mud crab (S. serrata Forsskål, 1775).Keywords: Pellet Size, Mud crab (S. serrata Forsskål, 1775), Specific growth rate (SGR)
Analisis Kadar Tanin Dalam Buah Mangrove Avicennia marina Dengan Perebusan Dan Lama Perendaman Air Yang Berbeda
Authors: Soenardjo Nirwani , Supriyantini Endang 
Published: June 2018

Mangrove fruit has the potential to be developed as a potential food source, but the presence of toxins in the fruit are considered harmful if consumed in the long run. Therefore, research needs to be done to eliminate or reduce the levels of toxins in the mangrove fruit, in order to increase the potential of the mangrove plants. The poison is in the mangrove fruit tannins. One alternative to reduce the levels of toxins in the fruit of the mangrove scrub with ash and water immersion.The purpose of this study was to determine the effect of treatment of ash powder content and the duration of water immersion on fruit tannin content of mangrove Avicennia.marina.The treatment was a long 24 hours of water immersion 4 times change of water (6 hours), 48 hours 8 times a change of water (6 hours), and 72 hours 12 times a change of water (6 hours). The results showed that treatment long soaking water to give a significant influence (P <0.05) toward decreased levels of mangrove Avicennia marina fruit tannins. Treatment a long 72 hours of water immersion 12 times a change of water (6 hours) to reduce levels of tannins by 28.80%. AbstrakBuah mangrove mempunyai potensi untuk dikembangkan menjadi sumber pangan yang potensial, akan tetapi dalam buahnya mengandung tannin . Tanin merupakan zat alami yang dihasilkan oleh buah mangrove yang memberi rasa getir. Oleh karena itu, perlu dilakukan penelitian untuk mengurangi kadar tannin dalam buah mangrove. Tujuan penelitian ini adalah untuk menganalisis pengaruh perlakuan lama waktu perendaman air terhadap kadar tanin buah mangrove A.marina.Perlakuan lama perendaman air 24 jam 4 kali pergantian air (6 jam), 48 jam 8 kali pergantian air (6 jam), dan 72 jam 12 kali pergantian air (6 jam). Hasil penelitian menunjukan bahwa perlakuan lama perendaman air memberikan pengaruh yang nyata (P < 0.05) terhadap penurunan kadar tanin buah mangrove Avicennia marina. Perlakuan lama perendaman air 72 jam 12 kali pergantian air (6 jam) menurunkan kadar tanin sebesar 28,80 %