bluuebunny/crossref_metadata_2025_split huggingface dataset:
Microtopography‐Guided Radial Gradient Circle Array Film with Nanoscale Resolution
Authors: Zhang Fengqiang , Li Changhai , Zhang Jia , Wang Zhenlong 
Published: October 2019

AbstractDistribution of multimaterials at arbitrary positions with nanoscale resolution and over a large area substrate is essential to future advances in functional graded materials. Such stringent requirements are highly beyond the reach of current techniques, although newly developed 3D printing technologies are addressed. Here, a radial gradient circle array film with the distribution accuracy up to ≈18 nm is fabricated by using microtopographic substrate. A mathematical model is developed to guide the distribution of position, size, shape, and type of materials on an arbitrary section for the given morphology of substrate. The periodic electrical and mechanical properties of the radial gradient circle film are identified, which can be beneficial for further functionalization and applications, such as gradient refractive index lenses, microcoils, and microantennas.
Composition Modulation and Structure Design of Inorganic‐in‐Polymer Composite Solid Electrolytes for Advanced Lithium Batteries
Authors: Liu Yuan , Xu Bingqing , Zhang Wenyu , Li Liangliang , Lin Yuanhua , Nan Cewen 
Published: October 2019

AbstractOwing to their safety, high energy density, and long cycling life, all‐solid‐state lithium batteries (ASSLBs) have been identified as promising systems to power portable electronic devices and electric vehicles. Developing high‐performance solid‐state electrolytes is vital for the successful commercialization of ASSLBs. In particular, polymer‐based composite solid electrolytes (PCSEs), derived from the incorporation of inorganic fillers into polymer solid electrolytes, have emerged as one of the most promising electrolyte candidates for ASSLBs because they can synergistically integrate many merits from their components. The development of PCSEs is summarized. Their major components, including typical polymer matrices and diverse inorganic fillers, are reviewed in detail. The effects of fillers on their ionic conductivity, mechanical strength, thermal/interfacial stability and possible Li+‐conductive mechanisms are discussed. Recent progress in a number of rationally constructed PCSEs by compositional and structural modulation based on different design concepts is introduced. Successful applications of PCSEs in various lithium‐battery systems including lithium–sulfur and lithium–gas batteries are evaluated. Finally, the challenges and future perspectives for developing high‐performance PCSEs are proposed.
Value of routine ultrasound examination at 35–37 weeks' gestation in diagnosis of fetal abnormalities
Authors: Ficara A. , Syngelaki A. , Hammami A. , Akolekar R. , Nicolaides K. H. 
Published: October 2019

ABSTRACTObjectiveTo investigate the potential value of routine ultrasound examination at 35–37 weeks' gestation in the diagnosis of previously unknown fetal abnormalities.MethodsThis was a prospective study of 52 400 singleton pregnancies attending for a routine ultrasound examination at 35 + 0 to 36 + 6 weeks' gestation; all pregnancies had a previous scan at 18–24 weeks and 47 214 also had a scan at 11–13 weeks. We included pregnancies resulting in live birth or stillbirth but excluded those with known chromosomal abnormality. Abnormalities were classified according to the affected major organ system, and the type and incidence of new abnormalities were determined.ResultsIn the study population, the incidence of fetal abnormality was 1.9% (995/52 400), including 674 (67.7%) that had been diagnosed previously during the first and/or second trimester, 247 (24.8%) that were detected for the first time at 35–37 weeks and 74 (7.4%) that were detected for the first time postnatally. The most common abnormalities that were diagnosed during the first and/or second trimester and that were also observed at 35–37 weeks included ventricular septal defect, talipes, unilateral renal agenesis and/or pelvic kidney, hydronephrosis, duplex kidney, unilateral multicystic kidney, congenital pulmonary airway malformation, ventriculomegaly, cleft lip and palate, polydactyly and abdominal cyst or gastroschisis. The most common abnormalities first seen at 35–37 weeks were hydronephrosis, mild ventriculomegaly, ventricular septal defect, duplex kidney, ovarian cyst and arachnoid cyst. The incidence of abnormalities first seen at 35–37 weeks was 0.5% and those that were detected exclusively for the first time at this examination were ovarian cyst, microcephaly, achondroplasia, dacryocystocele and hematocolpos. The incidence of abnormalities first seen postnatally was 0.1% and the most common were isolated cleft palate, polydactyly or syndactyly and ambiguous genitalia or hypospadias; prenatal examination of the genitalia was not a compulsory part of the protocol.ConclusionsA high proportion of fetal abnormalities are detected for the first time during a routine ultrasound examination at 35–37 weeks' gestation. Such diagnosis and subsequent management, including selection of timing and place for delivery and postnatal investigations, could potentially improve postnatal outcome. Copyright © 2019 ISUOG. Published by John Wiley & Sons Ltd.
Outcome of twin‐to‐twin transfusion syndrome in monochorionic monoamniotic twin pregnancy: systematic review and meta‐analysis
Authors: Murgano D. , Khalil A. , Prefumo F. , Mieghem T. Van , Rizzo G. , Heyborne K. D. , Melchiorre K. , Peeters S. , Lewi L. , Familiari A. , Lopriore E. , Oepkes D. , Murata M. , Anselem O. , Buca D. , Liberati M. , Hack K. , Nappi L. , Baxi L. V. , Scambia G. , Acharya G. , D'antonio F. 
Published: October 2019

ABSTRACTObjectivesTo explore the outcome of monochorionic monoamniotic (MCMA) twin pregnancies affected by twin‐to‐twin transfusion syndrome (TTTS).MethodsMEDLINE and EMBASE databases were searched for studies reporting the outcome of MCMA twin pregnancies complicated by TTTS. The primary outcome was intrauterine death (IUD); secondary outcomes were miscarriage, single IUD, double IUD, neonatal death (NND), perinatal death (PND), survival of at least one twin, survival of both twins and preterm birth (PTB) before 32 weeks' gestation. Outcomes were assessed in MCMA twins affected by TTTS not undergoing intervention and in those treated with amniodrainage, laser therapy or cord occlusion. Subgroup analysis was performed including cases diagnosed before 24 weeks. Random‐effects meta‐analysis of proportions was used to analyze the data.ResultsFifteen cohort studies, including 888 MCMA twin pregnancies, of which 44 were affected by TTTS, were included in the review. There was no randomized trial comparing the different management options in MCMA twin pregnancies complicated by TTTS. In cases not undergoing intervention, miscarriage occurred in 11.0% of fetuses, while the incidence of IUD, NND and PND was 25.2%, 12.2% and 31.2%, respectively. PTB complicated 50.5% of these pregnancies. In cases treated by laser surgery, the incidence of miscarriage, IUD, NND and PND was 19.6%, 27.4%, 7.4% and 35.9%, respectively, and the incidence of PTB before 32 weeks' gestation was 64.9%. In cases treated with amniodrainage, the incidence of IUD, NND and PND was 31.3%, 13.5% and 45.7% respectively, and PTB complicated 76.2% of these pregnancies. Analysis of cases undergoing cord occlusion was affected by the very small number of included cases. Miscarriage occurred in 19.2%, while there was no case of IUD or NND of the surviving twin. PTB before 32 weeks occurred in 50.0% of these cases.ConclusionsMCMA twin pregnancies complicated by TTTS are at high risk of perinatal mortality and PTB. Further studies are needed in order to elucidate the optimal type of prenatal treatment in these pregnancies. Copyright © 2019 ISUOG. Published by John Wiley & Sons Ltd.
Quantitative fetal magnetic resonance imaging assessment of cystic posterior fossa malformations
Authors: Dovjak G. O. , Diogo M. C. , Brugger P. C. , Gruber G. M. , Weber M. , Glatter S. , Seidl R. , Bettelheim D. , Prayer D. , Kasprian G. J. 
Published: October 2019

ABSTRACTObjectiveNormal cognitive development usually requires a structurally intact and complete cerebellar vermis. The aim of this study was to evaluate whether quantification by fetal magnetic resonance imaging (MRI) of vermis‐ and brainstem‐specific imaging markers improves the definition of cystic posterior fossa malformations (cPFM).MethodsFetuses diagnosed with cPFM that had an available midsagittal plane on T2‐weighted MRI were identified retrospectively and compared with gestational‐age (GA) matched brain‐normal controls. Fetuses with cPFM were assigned to three groups, according to standard criteria (vermian size and brainstem–vermis (BV) angle): normal vermian area and BV angle < 25° (Group 1); reduced vermian area and/or BV angle of 25–45° (Group 2); and reduced vermian area and BV angle > 45° (Group 3; Dandy–Walker malformation (DWM) group). The number of differentiable vermian lobules and the areas of the vermis, mesencephalon, pons and medulla oblongata were quantified, correlated with and controlled for GA, and compared between the study groups.ResultsIn total, 142 cases of cPFM were included, with a mean GA of 25.20 ± 5.11 weeks. Cases comprised Blake's pouch cyst (n = 46), arachnoid cyst (n = 12), inferior vermian hypoplasia (n = 5), megacisterna magna (n = 35) and classic DWM (n = 44). In the control group, 148 fetuses were included, with a mean GA of 25.26 ± 4.12 weeks. All quantified areas and the number of differentiable vermian lobules had a significant positive correlation with GA. The number of vermian lobules and the areas of all quantified regions, except for that of the medulla oblongata, differed significantly between the study groups (P ≤ 0.015 for all). The control group had the highest number of differentiable vermian lobules and the DWM group had the lowest (P < 0.01).ConclusionsPrenatal MRI assessment of vermian lobules is a useful addition to standard neuroradiological and neurosonographic techniques. The quantification of vermian lobules using fetal MRI allows further differentiation of cPFM into subgroups and thereby improves the classification of hindbrain malformations. © 2019 The Authors. Ultrasound in Obstetrics & Gynecology published by John Wiley & Sons Ltd on behalf of the International Society of Ultrasound in Obstetrics and Gynecology.
The potential anti‐infective applications of metal oxide nanoparticles: A systematic review
Authors: Abo‐zeid Yasmin , Williams Gareth R. 
Published: October 2019

AbstractMicrobial infections present a major global healthcare challenge, in large part because of the development of microbial resistance to the currently approved antimicrobial drugs. This demands the development of new antimicrobial agents. Metal oxide nanoparticles (MONPs) are a class of materials that have been widely explored for diagnostic and therapeutic purposes. They are reported to have wide‐ranging antimicrobial activities and to be potent against bacteria, viruses, and protozoans. The use of MONPs reduces the possibility of resistance developing because they have multiple mechanisms of action (including via reactive oxygen species generation), simultaneously attacking many sites in the microorganism. However, despite this there are to date no MONPs clinically approved for antimicrobial therapy. This review explores the recent literature in this area, discusses the mechanisms of MONP action against microorganisms, and considers the barriers faced to the use of MONPs in humans. These include biological challenges, of which the potential for an immune response and off‐target toxicity are key. We explore in detail the possible benefits/disbenefits of an immune response being initiated, and consider the effect of production method (chemical vs. green synthesis) on cytotoxicity. There are also a number of technical and manufacturing challenges hindering MONP translation to the clinic which are additionally discussed in depth. In the short term, there are potentially some “quick wins” from the repurposing of already‐approved nanoparticle‐based medicines for anti‐infective applications, but a number of hurdles, both technical and biological, lie in the path to long‐term clinical translation of new MONP‐based formulations.This article is categorized under:
Therapeutic Approaches and Drug Discovery > Nanomedicine for Infectious Disease
Therapeutic Approaches and Drug Discovery > Emerging Technologies
Toxicology and Regulatory Issues in Nanomedicine > Toxicology of Nanomaterials
Synthesis, characterization and physicochemical studies of copolymers of aniline and 3-nitroaniline
Authors: Waware Umesh Somaji , Hamouda A. M. S. , Majumdar Dipanwita 
Published: October 2019

Abstract
Polyaniline (PA), the versatile conducting polymer, owing to its tunable optoelectronic properties, facile preparation methodology and reversible redox behavior, has elicited much interest among current researchers, particularly in the fields of energy generation storage devices, protective coatings and electrochemical sensors. However, its commercialization has been much restricted due to low solution processability and thermal stability. Recent studies reveal that the above-mentioned challenges can effectively be addressed by copolymerization of PA with suitable components. In addition, the properties of copolymers could be modified and tuned by varying the monomer ratios. Thus, the present work is concerned with the fabrication of poly(aniline-co-3-nitroaniline) with varying compositions obtained by in situ oxidative copolymerization of aniline and 3-nitroaniline by altering the molar ratio of monomers. Optimization of the physicochemical properties such as UV–visible absorption, solubility, thermal stability, electrical conductivity and dielectric signatures, particle size and morphology was achieved by varying the composition of monomeric substituents in these copolymers. Smoother morphology of the copolymer films was revealed by morphological studies via AFM technique and supported by particle size distribution study. The physicochemical trends demonstrated that proper proportions of nitro (–NO2) group in the polymer chain are essential to achieve desired optimal physicochemical properties. Therefore, copolymers are ideally appropriate for multifaceted applications and would promote wider usage of conjugated polymers in various fields of organic-based optoelectronic as well as energy storage devices in the near future.
Application of Measurement While Drilling Technology to Predict Rock Mass Quality and Rock Support for Tunnelling
Authors: van Eldert Jeroen , Schunnesson Håkan , Johansson Daniel , Saiang David 
Published: October 2019

Abstract
A tunnelling project is normally initiated with a site investigation to determine the in situ rock mass conditions and to generate the basis for the tunnel design and rock support. However, since site investigations often are based on limited information (surface mapping, geophysical profiles, few bore holes, etc.), the estimation of the rock mass conditions may contain inaccuracies, resulting in underestimating the required rock support. The study hypothesised that these inaccuracies could be reduced using Measurement While Drilling (MWD) technology to assist in the decision-making process. A case study of two tunnels in the Stockholm bypass found the rock mass quality was severely overestimated by the site investigation; more than 45% of the investigated sections had a lower rock mass quality than expected. MWD data were recorded in 25 m grout holes and 6 m blast holes. The MWD data were normalised so that the long grout holes with larger hole diameters and the shorter blast holes with smaller hole diameters gave similar results. With normalised MWD data, it was possible to mimic the tunnel contour mapping; results showed good correlation with mapped Q-value and installed rock support. MWD technology can improve the accuracy of forecasting the rock mass ahead of the face. It can bridge the information gap between the early, somewhat uncertain geotechnical site investigation and the geological mapping done after excavation to optimise rock support.
Apple chlorotic fruit spot viroid: a putative new pathogenic viroid on apple characterized by next-generation sequencing
Authors: Leichtfried Thomas , Dobrovolny Stefanie , Reisenzein Helga , Steinkellner Siegrid , Gottsberger Richard A. 
Published: October 2019

Abstract
Viroid-like symptoms were observed in 2016 on apple fruits of the cultivar “Ilzer Rose” in southern Burgenland, Austria. Preliminary molecular biological investigations indicated that the symptoms were caused by a new unknown viroid. Therefore, new primers were designed, and the whole genome sequence of the viroid (354 nt) was determined by next-generation amplicon sequencing using the Illumina MiSeq® platform (San Diego, California, USA). The viroid secondary structure has a rod-like conformation and contains conserved regions (the TCR, CCR upper strand, and CCR lower strand) that are characteristic of members of the genus Apscaviroid. Based on our results and the demarcation criteria for viroids, the tentatively named “apple chlorotic fruit spot viroid” should be considered a putative new member of the genus Apscaviroid.
Tumour Initiation: a Discussion on Evidence for a “Load-Trigger” Mechanism
Authors: Evans John J. , Alkaisi Maan M. , Sykes Peter H. 
Published: October 2019

Abstract
Appropriate mechanical forces on cells are vital for normal cell behaviour and this review discusses the possibility that tumour initiation depends partly on the disruption of the normal physical architecture of the extracellular matrix (ECM) around a cell. The alterations that occur thence promote oncogene expression. Some questions, that are not answered with certainty by current consensus mechanisms of tumourigenesis, are elegantly explained by the triggering of tumours being a property of the physical characteristics of the ECM, which is operative following loading of the tumour initiation process with a relevant gene variant. Clinical observations are consistent with this alternative hypothesis which is derived from studies that have, together, accumulated an extensive variety of data incorporating biochemical, genetic and clinical findings. Thus, this review provides support for the view that the ECM may have an executive function in induction of a tumour. Overall, reported observations suggest that either restoring an ECM associated with homeostasis or targeting the related signal transduction mechanisms may possibly be utilised to modify or control the early progression of cancers. The review provides a coherent template for discussing the notion, in the context of contemporary knowledge, that tumourigenesis is an alliance of biochemistry, genetics and biophysics, in which the physical architecture of the ECM may be a fundamental component. For more definitive clarification of the concept there needs to be a phalanx of experiments conceived around direct questions that are raised by this paper.
ECLIM-SEHOP, a new platform to set up and develop international academic clinical trials for childhood cancer and blood disorders in Spain
Authors:   the Sociedad Española de Hematología y Oncología Pediátrica (SEHOP), Bautista F. , Cañete A. , Ramírez-Villar G. L. , Fernández J. M. , Fuster J. L. , Diaz de Heredia C. , Astigarraga I. , García-Ariza M. , Rives S. , Dapena J. L. , Márquez C. , Molinés A. , Bermúdez M. del M. , Gallego S. , Andrés M. del M. , Verdu-Amoros J. , Hernández C. , López M. , Catalá A. , Lassaletta Á. , Cruz O. , Ramírez M. , Lendínez F. , Carboné A. , Gomez Sirvent J. , Tallón M. , Acha T. , Moreno L. , Fernández-Teijeiro A. 
Published: October 2019

Abstract

Introduction
Cancer and blood disorders in children are rare. The progressive improvement in survival over the last decades largely relies on the development of international academic clinical trials that gather the sufficient number of patients globally to elaborate solid conclusions and drive changes in clinical practice. The participation of Spain into large international academic trials has traditionally lagged behind of other European countries, mainly due to the burden of administrative tasks to open new studies, lack of financial support and limited research infrastructure in our hospitals.

Methods
The objective of ECLIM-SEHOP platform (Ensayos Clínicos Internacionales Multicéntricos-SEHOP) is to overcome these difficulties and position Spain among the European countries leading the advances in cancer and blood disorders, facilitate the access of our patients to novel diagnostic and therapeutic approaches and, most importantly, continue to improve survival and reducing long-term sequelae. ECLIM-SEHOP provides to the Spanish clinical investigators with the necessary infrastructural support to open and implement academic clinical trials and registries.

Results
In less than 3 years from its inception, the platform has provided support to 20 clinical trials and 8 observational studies, including 8 trials and 4 observational studies where the platform performs all trial-related tasks (integral support: trial setup, monitoring, etc.) with more than 150 patients recruited since 2017 to these studies. In this manuscript, we provide baseline metrics for academic clinical trial performance that permit future comparisons.

Conclusions
ECLIM-SEHOP facilitates Spanish children and adolescents diagnosed with cancer and blood disorders to access state-of-the-art diagnostic and therapeutic strategies.
Negative views of out-groups and emotion regulation strategies: Evidence for an association with the tendency to suppress emotion expression, but not with cognitive reappraisal or emotion dysregulation
Authors: Westerlund Minja , Antfolk Jan , Santtila Pekka 
Published: October 2019

AbstractEmotions influence attitudes and appraisals toward out-groups, including prejudice. We hypothesized that individuals who successfully regulate emotions will express more positive attitudes toward out-groups. We conducted an online study of associations between emotion regulation and attitudes toward out-groups in a Finnish population-based sample (N = 320). As hypothesized, expressive suppression was associated with decreased acceptance toward out-groups, but contrary to our hypothesis, cognitive reappraisal was not associated with increased acceptance. In exploratory analyses, we found that individuals with more cognitive reappraisal (vs. expressive suppression) had a higher acceptance of out-groups, and that emotion regulation may not influence attitudes toward all out-groups equally. In conclusion, we present novel results indicating that habitual emotion regulation strategies are differently associated with attitudes toward a broad array of out-groups, and that the sociocultural aspects of emotion regulation toward out-group attitudes may play a role.
Predicting the effects of eutrophication mitigation on predatory fish biomass and the value of recreational fisheries
Authors: Sundblad Göran , Bergström Lena , Söderqvist Tore , Bergström Ulf 
Published: October 2019

Abstract
Improving water clarity is a core objective for eutrophication management in the Baltic Sea, but may influence fisheries via effects on fish habitat suitability. We apply an ensemble of species distribution models coupled with habitat productivity functions and willingness-to-pay estimates to assess these effects for two coastal predatory fish species, European perch (Perca fluviatilis) and pikeperch (Sander lucioperca). The models predicted a 37% increase in perch and 59% decrease in pikeperch biomass if reaching the reference level for water clarity in the Baltic Sea Action Plan. Reaching the target level was predicted to increase perch biomass by 13%. However, the associated economic gain for the recreational fisheries sector was countervailed by an 18% pikeperch reduction. Still, a net benefit was predicted since there are six times more fishing days for perch than pikeperch. We exemplify how ecological modelling can be combined with economic analyses to map and evaluate management alternatives.