bluuebunny/crossref_metadata_2025_split huggingface dataset:
Distal extremities soft tissue sarcomas: Are they so different from other limb localizations?
Authors: Mattei Jean‐Camille , Brouste Véronique , Terrier Philippe , Bonvalot Sylvie , Lecesne Axel , Stoeckle Eberhard , Italiano Antoine , Ranchere‐Vince Dominique , Meeus Pierre , Laé Marick , Rosset Philippe , Rochwerger Alexandre , Coindre Jean Michel , Salas Sébastien 
Published: January 2019

Background and ObjectivesSoft tissue sarcoma localization in distal extremities (DESTS) of the limbs (hand/fingers, and foot/toes) is unusual. The literature is scarce about their behavior and this study was designed to assess their epidemiological characteristics, outcomes, and prognosis compared to other limb localizations (OLSTS).MethodsFrom 1980 to 2010, adult DESTS and OLSTS in 22 centers were included. Demographics, tumor type, treatment modalities, and latest follow‐up status were collected. Primary endpoints were overall survival and local/metastatic recurrence incidences.ResultsTwo hundred five DESTS and 3001 OLSTS were included. The patients were younger, with more female and smaller tumors in DESTS. There were more clear cell/epithelioid sarcomas, synovial sarcomas, and myxoid liposarcomas vs more dedifferentiated liposarcomas in OLSTS. DESTS tumors were less irradiated and more often amputated (24.3% vs 3.4%). The five‐year survival rate was 78.2% compared to 68.6% in OLSTS and after multivariate analysis, STS localization did not impact survival or local/metastatic recurrence.ConclusionThough rare and smaller than other limb localizations, DESTS are to be considered as aggressive. Despite a higher amputation rate, the prognosis remains the same as in OLSTS. Limb sparing vs amputation should be carefully assessed in DESTS, especially if grade 3 or of a poor prognosis histological subtype.
Outcomes after hypofractionated stereotactic radiotherapy for colorectal cancer oligometastases
Authors: Yu Jing , Li Ning , Tang Yu , Wang Xin , Tang Yuan , Wang Shu‐Lian , Song Yong‐Wen , Liu Yue‐Ping , Li Ye‐Xiong , Jin Jing 
Published: January 2019

Background and ObjectivesTo assess the efficacy and the effect of biologic effective dose (BED) on outcomes treated by hypofractionated stereotactic radiotherapy for colorectal cancer (CRC) oligometastases.MethodsPatients with CRC oligometastases treated at our hospital between 2009 and 2016 were included. The relationship between BED and risk of local recurrence was assessed. Recursive partitioning analysis (RPA) was used to evaluate the effect of BED on outcomes.ResultsA total of 48 patients were included in this study. Median follow‐up time of surviving patient was 15 months (range, 3‐82 months). The 1‐year local control rate was 85%. The risk of local recurrence decreased sharply when BED was >90 Gy10. RPA showed BED of 100 Gy
10 was the appropriate dose for recurrence risk stratification. BED ≥ 100 Gy
10 was significantly better than BED < 100 Gy
10 for achieving 1‐year local control (94.4% vs 63.2%; P = 0.022) and 1‐year OS (100% vs 73.4%; P = 0.028). One patient who received long‐term antiangiogenic treatment died of massive intestinal hemorrhage; no other grade 3 or above early or late events were observed.ConclusionsHypofractionated stereotactic radiotherapy provides favorable outcomes with acceptable toxicities in CRC oligometastases. BED ≥ 100 Gy is associated with better outcomes.
Optically reconfigurable planar monopole antenna for cognitive radio application
Authors: Ali Abdul , Topalli Kagan , Ramzan Mehrab , Alibakhshikenari Muhammad , Khan Talha Masood , Altintas Ayhan , Colantonio Paolo 
Published: January 2019

AbstractFrequency reconfigurable antenna is one of the important elements needed for cognitive radio application. Such antenna can be designed using highly resistive (HR) silicon (Si) operating as an optical switch. This letter presents a novel frequency reconfigurable planar monopole antenna suitable for cognitive radio application. The antenna is designed using HR Si working as an optical switch. The main idea behind the design of antenna is the redistribution of surface current on the antenna while changing the state of Si switches optically from high resistance to low resistance. The antenna is highly compact and uses only two switches for multiband reconfiguration. It is switchable on 1.9 GHz, 2.75 GHz, 3.7 GHz, 4.1 GHz, 4.6 GHz, 4.8 GHz, and 7.6 to 11 GHz frequency bands. Simulated and measured results are presented for the antenna. To the best of authors knowledge, this is the first multiband optically reconfigurable planar monopole antenna.
Risk of post‐traumatic knee osteoarthritis after knee injury in military service members
Authors: Rhon Daniel I. , Perez Katheryne G. , Eskridge Susan L. 
Published: January 2019

AbstractPurposeThe aims of the present study were: (a) to identify the incidence of osteoarthritis (OA) after a traumatic knee injury; (b) identify the risk of post‐traumatic osteoarthritis (PTOA) based on the type of injury; and (c) identify the time from injury to OA diagnosis.Patients and methodsThe Expeditionary Medical Encounter Database, containing healthcare utilization for all deployment injuries sustained by military service members, was queried for traumatic knee injuries between 2001 and 2016. Subsequent diagnosis of knee OA was identified, defined as PTOA. Time to knee PTOA diagnosis was determined and logistic regression was used to obtain odds ratios (ORs) (95% confidence interval [CI]) between knee injury type and development of PTOA.ResultsA total of 345 (9.57%) of the 3,605 subjects were diagnosed with PTOA. The median time to diagnosis was 4.10 years. Four primary diagnoses remained significantly associated with PTOA after adjusting for age and injury severity score: fracture (adjusted OR [aOR] = 1.36; 95% CI 1.02, 1.82), sprain (aOR = 1.59; 95% CI 1.23, 2.06), dislocation (aOR = 3.70; 95% CI 2.09, 6.55) and derangement (aOR = 2.38; 95% CI 1.33, 4.28). Subjects were significantly less likely to develop PTOA after a soft‐tissue injury (aOR = 0.44; 95% CI 0.41, 0.75).ConclusionsA substantial number of individuals with a traumatic knee injury developed early PTOA (9.6%). Certain knee injuries have a greater association with PTOA. Future studies should implement longer surveillance periods and identify other healthcare variables associated with the risk of developing PTOA, to include appropriate and timely interventions.
Metabolomic prostate cancer fields in HRMAS MRS‐profiled histologically benign tissue vary with cancer status and distance from cancer
Authors: Dinges Sarah S. , Vandergrift Lindsey A. , Wu Shulin , Berker Yannick , Habbel Piet , Taupitz Matthias , Wu Chin‐Lee , Cheng Leo L. 
Published: January 2019

In this article, we review the state of the field of high resolution magic angle spinning MRS (HRMAS MRS)‐based cancer metabolomics since its beginning in 2004; discuss the concept of cancer metabolomic fields, where metabolomic profiles measured from histologically benign tissues reflect patient cancer status; and report our HRMAS MRS metabolomic results, which characterize metabolomic fields in prostatectomy‐removed cancerous prostates. Three‐dimensional mapping of cancer lesions throughout each prostate enabled multiple benign tissue samples per organ to be classified based on distance from and extent of the closest cancer lesion as well as the Gleason score (GS) of the entire prostate. Cross‐validated partial least squares‐discriminant analysis separations were achieved between cancer and benign tissue, and between cancer tissue from prostates with high (≥4 + 3) and low (≤3 + 4) GS. Metabolomic field effects enabled histologically benign tissue adjacent to cancer to distinguish the GS and extent of the cancer lesion itself. Benign samples close to either low GS cancer or extensive cancer lesions could be distinguished from those far from cancer. Furthermore, a successfully cross‐validated multivariate model for three benign tissue groups with varying distances from cancer lesions within one prostate indicates the scale of prostate cancer metabolomic fields. While these findings could, at present, be potentially useful in the prostate cancer clinic for analysis of biopsy or surgical specimens to complement current diagnostics, the confirmation of metabolomic fields should encourage further examination of cancer fields and can also enhance understanding of the metabolomic characteristics of cancer in myriad organ systems. Our results together with the success of HRMAS MRS‐based cancer metabolomics presented in our literature review demonstrate the potential of cancer metabolomics to provide supplementary information for cancer diagnosis, staging, and patient prognostication.
Comparison of two sweat test systems for the diagnosis of cystic fibrosis in newborns
Authors: Rueegg Corina S. , Kuehni Claudia E. , Gallati Sabina , Jurca Maja , Jung Andreas , Casaulta Carmen , Barben Juerg ,   for the Swiss Cystic Fibrosis Screening Group
Published: January 2019

AbstractObjectivesIn the national newborn screening programme for CF in Switzerland, we compared the performance of two sweat test methods, by investigating the feasibility and diagnostic performance of the Macroduct® collection method (with chloride mesurement) and Nanoduct® test (measuring conductivity) for diagnosing CF.Study‐DesignWe included all newborns with a positive screening result between 2011 and 2015 who were referred to a CF‐centre for sweat testing. In the CF‐centre, a Macroduct and Nanoduct sweat test were performed simultaneously. If sweat test results were positive or borderline, a DNA analysis was performed. Final diagnosis was based on genetic mutations.ResultsOver 5 years, 445 children were screened positive and in 413 (114 with CF) at least one sweat test was performed (median age at first test, 22 days); both tests were performed in 371 children. A sweat test result was more often available with the Nanoduct compared to the Macroduct (79 vs 60%, P < 0.001). The Nanoduct was equally sensitive as the Macroduct in identifying newborns with CF (sensitivity 98 vs 99%) but less specific (specificity 79 vs 93%; P‐value comparing ROC curves = 0.033).ConclusionsThis national multicentre study revealed high failure rates for Macroduct and Nanoduct in newborns in real life practice. While this needs to be addressed, our results suggested that performing the Nanoduct in addition to the Macroduct might speed up the diagnostic process because it more often yields valid results with comparable diagnostic performance. The addition of the Nanoduct sweat test can therefore help to reduce the stressful time of uncertainty for parents and to start appropriate treatment earlier.
New assay method based on Raman spectroscopy for enzymes reacting with gaseous substrates
Authors: Kawahara‐Nakagawa Yuka , Nishikawa Koji , Nakashima Satoru , Inoue Shota , Ohta Takehiro , Ogura Takashi , Shigeta Yasuteru , Fukutani Katsuyuki , Yagi Tatsuhiko , Higuchi Yoshiki 
Published: January 2019

AbstractEnzyme activity is typically assayed by quantitatively measuring the initial and final concentrations of the substrates and/or products over a defined time period. For enzymatic reactions involving gaseous substrates, the substrate concentrations can be estimated either directly by gas chromatography or mass spectrometry, or indirectly by absorption spectroscopy, if the catalytic reactions involve electron transfer with electron mediators that exhibit redox‐dependent spectral changes. We have developed a new assay system for measuring the time course of enzymatic reactions involving gaseous substrates based on Raman spectroscopy. This system permits continuous monitoring of the gas composition in the reaction cuvette in a non‐invasive manner over a prolonged time period. We have applied this system to the kinetic study of the [NiFe] hydrogenase fromDesulfovibrio vulgarisMiyazaki F. This enzyme physiologically catalyzes the reversible oxidation of H2and also possesses the nonphysiological functions of H/D exchange and nuclear spin isomer conversion reactions. The proposed system has the additional advantage of enabling us to measure all of the hydrogenase‐mediated reactions simultaneously. Using the proposed system, we confirmed that H2(the fully exchanged product) is concomitantly produced alongside HD by the H/D exchange reaction in the D2/H2O system. Based on a kinetic model, the ratio of the rate constants of the H/D exchange reaction (k) at the active site and product release rate (kout) was estimated to be 1.9 ± 0.2. The proposed assay method based on Raman spectroscopy can be applied to the investigation of other enzymes involving gaseous substrates.
Salicylate enhances the response of prostate cancer to radiotherapy
Authors: Broadfield Lindsay A. , Marcinko Katarina , Tsakiridis Evangelia , Zacharidis Panayiotis G. , Villani Linda , Lally James S. V. , Menjolian Gabe , Maharaj Danitra , Mathurin Tammy , Smoke Marcia , Farrell Thomas , Muti Paola , Steinberg Gregory R. , Tsakiridis Theodoros 
Published: January 2019

BackgroundRadiotherapy (RT) is a key therapeutic modality for prostate cancer (PrCa), but RT resistance necessitates dose‐escalation, often causing bladder and rectal toxicity. Aspirin, a prodrug of salicylate (SAL), has been associated with improved RT response in clinical PrCa cases, but the potential mechanism mediating this effect is unknown. SAL activates the metabolic stress sensor AMP‐activated protein kinase (AMPK), which inhibits de novo lipogenesis, and protein synthesis via inhibition of Acetyl‐CoA Carboxylase (ACC), and the mammalian Target of Rapamycin (mTOR), respectively. RT also activates AMPK through a mechanism distinctly different from SAL. Therefore, combining these two therapies may have synergistic effects on suppressing PrCa. Here, we examined the potential of SAL to enhance the response of human PrCa cells and tumors to RT.MethodsAndrogen‐insensitive (PC3) and ‐sensitive (LNCaP) PrCa cells were subjected to proliferation and clonogenic survival assays after treatment with clinically relevant doses of SAL and RT. Balb/c nude mice with PC3 xenografts were fed standard chow diet or chow diet supplemented with 2.5 g/kg salsalate (SAL pro‐drug dimer) one week prior to a single dose of 0 or 10 Gy RT. Immunoblotting analysis of signaling events in the DNA repair and AMPK‐mTOR pathways and lipogenesis were assessed in cells treated with SAL and RT.ResultsSAL inhibited proliferation and clonogenic survival in PrCa cells and enhanced the inhibition mediated by RT. Salsalate, added to diet, enhanced the anti‐tumor effects of RT in PC3 tumor xenografts. RT activated genotoxic stress markers and the activity of mTOR pathway and AMPK and mediated inhibitory phosphorylation of ACC. Interestingly, SAL enhanced the effects of RT on AMPK and ACC but blocked markers of mTOR activation.ConclusionsOur results show that SAL can enhance RT responses in PrCa. Salsalate is a promising agent to investigate this concept in prospective clinical trials of PrCa in combination with RT.
Management of flatheaded appletree borer (Chrysobothris femorata Olivier) in woody ornamental nursery production with a winter cover crop
Authors: Dawadi Sujan , Oliver Jason B , O'Neal Paul , Addesso Karla M 
Published: January 2019

AbstractBACKGROUNDThe flatheaded appletree borer (Chrysobothris femorata Olivier) (FHAB) is a native pest of fruit, shade and nut trees throughout the United States. Use of cover crops is an effective pest management tool for some key insect pests in vegetable and cereal production systems, but its impact in woody ornamental production systems has not been investigated. The goal of this study was to evaluate the effectiveness of a winter cover crop for management of FHAB in nursery production. Red maple trees (Acer rubrum L.) grown under four treatment regimes (cover crop, cover crop + insecticide, bare row and bare row + insecticide) were evaluated for damage by FHAB and impact on tree growth parameters.RESULTSThe cover crop reduced FHAB damage, with results equivalent to standard imidacloprid treatments. The reduction in FHAB attacks in cover crop treatments may be due to microclimate changes at preferred oviposition sites, trunk camouflage or interference with access to oviposition sites. Tree growth was reduced in the cover crop treatments due to competition for resources.CONCLUSIONPhysical blockage of oviposition sites by cover crops and subsequent microclimate changes protected against FHAB damage. Therefore, cover crops can be an alternative to chemical insecticides. © 2019 Society of Chemical Industry
Systematic review of spontaneous splenic rupture in dengue‐infected patients
Authors: Radwan Ibrahim , Magdy Khattab Mohamed , Mahmoud Abdalla Reda , Nghia Thai Le Ba , Y Mai Nhu , Trung Dinh The , Hirayama Kenji , Huy Nguyen Tien 
Published: January 2019

SummaryDengue infection varies from a mild febrile form to more severe disease with plasma leakage, shock, and multiorgan failure. Several serious complications such as cardiomyopathy, encephalopathy, encephalitis, hepatic damage, and neural manifestations cause organ damage in dengue infection. Splenic rupture, a less well known but life‐threatening complication, can occur in dengue. The mechanism of splenic rupture in dengue is still unclear. Optimal therapeutic management is required to save the lives of patients with this complication. The objective of this study was to conduct a systematic review of studies documenting the development of spontaneous nontraumatic splenic rupture in patients with dengue infection. In March 2018, a search was conducted systematically in nine electronic databases, in addition to hand‐ searching. A total of 127 references were exported to Endnote; 47 references remained after removing duplicates. Finally, 16 reports met the inclusion criteria and represented 17 cases. All articles were evaluated and data extracted according to predefined criteria: number of cases, age, sex, severity of dengue disease, days of illness before admission, methods of definitive diagnosis, timing of the event, and management and outcome. A total of 17 individual patients including 13 males and four females were found. Most of the patients were young adults (ranging from 20 to 52 years) and diagnosed with computed tomography scan and managed with splenectomy. Four cases were fatal. Pathological splenic rupture in dengue is a rare, life‐threatening condition where timely management can achieve a favorable outcome.
Autonomous landing on a moving vehicle with an unmanned aerial vehicle
Authors: Baca Tomas , Stepan Petr , Spurny Vojtech , Hert Daniel , Penicka Robert , Saska Martin , Thomas Justin , Loianno Giuseppe , Kumar Vijay 
Published: January 2019

AbstractThis paper addresses the perception, control, and trajectory planning for an aerial platform to identify and land on a moving car at 15 km/hr. The hexacopter unmanned aerial vehicle (UAV), equipped with onboard sensors and a computer, detects the car using a monocular camera and predicts the car future movement using a nonlinear motion model. While following the car, the UAV lands on its roof, and it attaches itself using magnetic legs. The proposed system is fully autonomous from takeoff to landing. Numerous field tests were conducted throughout the year‐long development and preparations for the Mohamed Bin Zayed International Robotics Challenge (MBZIRC) 2017 competition, for which the system was designed. We propose a novel control system in which a model predictive controller is used in real time to generate a reference trajectory for the UAV, which are then tracked by the nonlinear feedback controller. This combination allows to track predictions of the car motion with minimal position error. The evaluation presents three successful autonomous landings during the MBZIRC 2017, where our system achieved the fastest landing among all competing teams.
Perceived stress in human–machine interaction in modern manufacturing environments—Results of a qualitative interview study
Authors: Körner Ulrike , Müller‐Thur Kathrin , Lunau Thorsten , Dragano Nico , Angerer Peter , Buchner Axel 
Published: January 2019

AbstractRapid advances in digitization technologies are changing modern working conditions especially in industrial settings. Consequently, employees are confronted with new forms of human–machine interaction. Whether changes in working conditions in general, and the increasing relevance of human–machine interaction in particular, affect psychosocial working conditions, and employee's health is currently matter of debate, but empirical data are lacking. Therefore, we conducted semistructured interviews with 36 employees working in five different companies. The interviews were aimed at identifying potential stressors associated with the introduction and use of modern technologies in the manufacturing industry.The results show that stressors linked to human–machine interaction are technical problems, poor usability, low situation awareness, and increased requirements on employees' qualification. For example, technical problems such as breakdowns or slowdowns were described as a main stressor when employees were not qualified to handle these problems on their own, thus decelerating work flows and causing additional time pressure. Overall, the results show that problems in human–machine interaction, which have been observed in laboratory and nonindustrial settings, also apply to industrial work places with highly automated working conditions and are a potential source of stress. These factors should be considered in psychosocial risk assessment of work‐related stressors.
Utilizing PLC Data for Workpiece Flaw Detection in Machine Tools
Authors: Sossenheimer Johannes , Bauerdick Christoph J. H. , Helfert Mark , Petruschke Lars , Abele Eberhard 
Published: January 2019

AbstractWorkpiece quality is one of the essential goals of every production company, due to the fact that it is strongly related to customer satisfaction and therefore to sales revenue and business success. While in single-part production every product can be checked for quality issues, this is inefficient in higher volume series production. Hence, random sampling is a widespread method for quality control in high-volume production. The problem with this method is that it just uses samples. Defect workpieces in between the samples are not recognized and therefore processed further on. In this chapter, an approach for monitoring systems for higher volume series production in machine tools is introduced to implement a 100% quality monitoring. It is utilizing the already implemented sensor network that is delivering its data to the machine PLC of the machine tool to indirectly measure the quality.
Simulation of Machining Operations Based on the VMT Concept
Authors: Cugnon Frédéric , Delsemme Jean-Pierre 
Published: January 2019

AbstractThis section focusses on the dynamic modelling of the machine tool including its computer numeric control, and its interaction with the machining process. To properly simulate modern machine tools in machining condition, the virtual machine tool model based on SAMCEF Mecano is used to account for close interaction between the dynamic behaviour of the mechanical structure, drives and the control. To fully capture the dynamic behaviour of the machine, force interactions between the cutting tool and the workpiece are also considered. A strong coupling between the mechatronic model of the machine tool and a machining simulation tool is implemented. A specialized cutting force element has been developed. It considers the dynamics of the tooltip combined with the tool-workpiece engagement to generate cutting forces. The use of such digital twin model is demonstrated considering some machining operations.