bluuebunny/crossref_metadata_2025_split huggingface dataset:
New clinicopathological associations and histoprognostic markers in ILAE types of hippocampal sclerosis
Authors: Calderon‐Garcidueñas Ana Laura , Mathon Bertrand , Lévy Pierre , Bertrand Anne , Mokhtari Karima , Samson Véronique , Thuriès Valérie , Lambrecq Virginie , Nguyen‐Michel Vi‐Huong , Dupont Sophie , Adam Claude , Baulac Michel , Clémenceau Stéphane , Duyckaerts Charles , Navarro Vincent , Bielle Franck 
Published: February 2018

AbstractMesial temporal lobe epilepsy with hippocampal sclerosis (MTLE‐HS) is a heterogeneous syndrome. Surgery results in seizure freedom for most pharmacoresistant patients, but the epileptic and cognitive prognosis remains variable. The 2013 International League Against Epilepsy (ILAE) histopathological classification of hippocampal sclerosis (HS) has fostered research to understand MTLE‐HS heterogeneity. We investigated the associations between histopathological features (ILAE types, hypertrophic CA4 neurons, granule cell layer alterations, CD34 immunopositive cells) and clinical features (presurgical history, postsurgical outcome) in a monocentric series of 247 MTLE‐HS patients treated by surgery. NeuN, GFAP and CD34 immunostainings and a double independent pathological examination were performed. 186 samples were type 1, 47 type 2, 7 type 3 and 7 samples were gliosis only but no neuronal loss (noHS). In the type 1, hypertrophic CA4 neurons were associated with a worse postsurgical outcome and granule cell layer duplication was associated with generalized seizures and episodes of status epilepticus. In the type 2, granule cell layer duplication was associated with generalized seizures. CD34+ stellate cells were more frequent in the type 2, type 3 and in noHS. These cells had a Nestin and SOX2 positive, immature neural immunophenotype. Patients with nodules of CD34+ cells had more frequent dysmnesic auras. CD34+ stellate cells in scarce pattern were associated with higher ratio of normal MRI and of stereo‐electroencephalographic studies. CD34+ cells were associated with a trend for a better postsurgical outcome. Among CD34+ cases, we proposed a new entity of BRAF V600E positive HS and we described three hippocampal multinodular and vacuolating neuronal tumors. To conclude, our data identified new clinicopathological associations with ILAE types. They showed the prognostic value of CA4 hypertrophic neurons. They highlighted CD34+ stellate cells and BRAF V600E as biomarkers to further decipher MTLE‐HS heterogeneity.
New‐onset refractory status epilepticus (NORSE) and febrile infection–related epilepsy syndrome (FIRES): State of the art and perspectives
Authors: Gaspard Nicolas , Hirsch Lawrence J. , Sculier Claudine , Loddenkemper Tobias , van Baalen Andreas , Lancrenon Judette , Emmery Michel , Specchio Nicola , Farias‐Moeller Raquel , Wong Nora , Nabbout Rima 
Published: February 2018

SummaryWe report the proceedings of the First International new‐onset refractory status epilepticus (NORSE) and febrile infection‐related epilepsy syndrome (FIRES) Symposium. To promote awareness of this condition and foster research efforts, we conveyed the First International new‐onset refractory status epilepticus (NORSE) and febrile infection‐related epilepsy syndrome (FIRES) Symposium. The conference was supported by The NORSE Institute (http://www.norseinstitute.org). This article summarizes the discussions that were held during the Symposium and presents our strategy to unravel the cause of these disorders and to improve patient care. The standardized definitions for these disorders that have been developed, are required to improve communication and facilitate the development of multicenter registries and biobanks. A distinction between childhood‐ and adult‐onset forms of the syndrome is not supported by strong scientific evidence and it is argued that both should be studied together. Although the pathophysiology remains elusive, nascent evidence suggests a role for a postinfectious cytokine‐mediated mechanism, which should be further investigated. It also appears important to develop tools for their early recognition and prompt treatment. Recent evidence suggests that specific electroencephalography (EEG) features might be helpful. The optimal treatment options remain to be determined; immune therapies are usually disappointing, but the ketogenic diet has proved effective in uncontrolled trials. NORSE and FIRES represent a very delicate clinical situation with specific communication issues between physicians and with patients and families. Standardized consensus definitions and a multidisciplinary multicenter strategy will help research efforts and improve clinical care for patients with NORSE and FIRES.
Adaptive deletion in resistance gene duplications in the malaria vector Anopheles gambiae
Authors: Assogba Benoît S. , Alout Haoues , Koffi Alphonsine , Penetier Cédric , Djogbénou Luc S. , Makoundou Patrick , Weill Mylène , Labbé Pierrick 
Published: February 2018

AbstractWhile gene copy‐number variations play major roles in long‐term evolution, their early dynamics remains largely unknown. However, examples of their role in short‐term adaptation are accumulating: identical repetitions of a locus (homogeneous duplications) can provide a quantitative advantage, while the association of differing alleles (heterogeneous duplications) allows carrying two functions simultaneously. Such duplications often result from rearrangements of sometimes relatively large chromosome fragments, and even when adaptive, they can be associated with deleterious side effects that should, however, be reduced by subsequent evolution. Here, we took advantage of the unique model provided by the malaria mosquito Anopheles gambiae s.l. to investigate the early evolution of several duplications, heterogeneous and homogeneous, segregating in natural populations from West Africa. These duplications encompass ~200 kb and 11 genes, including the adaptive insecticide resistance ace‐1 locus. Through the survey of several populations from three countries over 3–4 years, we showed that an internal deletion of all coamplified genes except ace‐1 is currently spreading in West Africa and introgressing from An. gambiae s.s. to An. coluzzii. Both observations provide evidences of its selection, most likely due to reducing the gene‐dosage disturbances caused by the excessive copies of the nonadaptive genes. Our study thus provides a unique example of the early adaptive trajectory of duplications and underlines the role of the environmental conditions (insecticide treatment practices and species ecology). It also emphasizes the striking diversity of adaptive responses in these mosquitoes and reveals a worrisome process of resistance/cost trade‐off evolution that could impact the control of malaria vectors in Africa.
Jockeying for Position in CEO Letters: Impression Management and Sentiment Analytics
Authors: Boudt Kris , Thewissen James 
Published: February 2018

AbstractThis paper evidences the strategic positioning of positive and negative words within a CEO letter as a subtle form of impression management. We find that managers tend to present information in such an order that the reader of the CEO letter has a more positive perception of the underlying message. We uncover a smile in the frequency of positive words within the letter, and a half smile in the intratextual distribution of negative words, with a prevalence of negative words at the beginning of the letter. We also find a significant positive association between this qualitative impression management and the use of abnormal accruals in earnings management. We propose sentiment analytics that can compensate for the strategic management of narrative structure and find that the proposed position weighted sentiment has more predictive power for the firm performance over the next year.
Experimental strategies to assess the biological ramifications of multiple drivers of global ocean change—A review
Authors: Boyd Philip W. , Collins Sinead , Dupont Sam , Fabricius Katharina , Gattuso Jean‐Pierre , Havenhand Jonathan , Hutchins David A. , Riebesell Ulf , Rintoul Max S. , Vichi Marcello , Biswas Haimanti , Ciotti Aurea , Gao Kunshan , Gehlen Marion , Hurd Catriona L. , Kurihara Haruko , McGraw Christina M. , Navarro Jorge M. , Nilsson Göran E. , Passow Uta , Pörtner Hans‐Otto 
Published: February 2018

AbstractMarine life is controlled by multiple physical and chemical drivers and by diverse ecological processes. Many of these oceanic properties are being altered by climate change and other anthropogenic pressures. Hence, identifying the influences of multifaceted ocean change, from local to global scales, is a complex task. To guide policy‐making and make projections of the future of the marine biosphere, it is essential to understand biological responses at physiological, evolutionary and ecological levels. Here, we contrast and compare different approaches to multiple driver experiments that aim to elucidate biological responses to a complex matrix of ocean global change. We present the benefits and the challenges of each approach with a focus on marine research, and guidelines to navigate through these different categories to help identify strategies that might best address research questions in fundamental physiology, experimental evolutionary biology and community ecology. Our review reveals that the field of multiple driver research is being pulled in complementary directions: the need for reductionist approaches to obtain process‐oriented, mechanistic understanding and a requirement to quantify responses to projected future scenarios of ocean change. We conclude the review with recommendations on how best to align different experimental approaches to contribute fundamental information needed for science‐based policy formulation.
Response of primary and secondary rainforest flowers and fruits to a cyclone, and implications for plant‐servicing bats
Authors: Scanlon Annette T. , Petit Sophie , Tuiwawa Marika , Naikatini Alivereti 
Published: February 2018

AbstractThe response of primary (PF) and secondary (SF) rainforests to cyclones has broad implications for servicing fauna and the resilience of forest functions. We collected fine‐scale data on the reproductive phenology of plant communities in Fijian PF and SF in 12 monthly surveys before and after Cyclone Tomas (2010). We generated a resource index from the reproductive loads of 2218 trees and 1150 non‐trees (>190 species) and trunk and stem diameter to assess patterns in resource abundance for nectarivores and frugivores (hereafter NF resources). We aimed to determine (i) whether species richness of NF resources differed between forests; (ii) the patterns of resilience of NF resources at community level in both forests after a cyclone; and (iii) the effect of response on NF resources for plant‐servicing bats (Pteropodidae). In 12 months preceding the cyclone, NF resources were greater in PF trees; non‐tree resources fluctuated and were greater in SF. Lower species richness of NF resources in SF indicated that fewer opportunities exist there for exploitation by a diverse fauna. More resources were available for bats in PF. In 12 months following the cyclone, PF flowers and fruits, and SF fruits specifically used by pteropodid bats decreased for trees. Non‐tree resources were especially susceptible to the cyclone. No universal pattern of decline was associated with the cyclone; instead, some NF resources declined and others were resilient or responded rapidly to a post‐cyclone environment. Both PF and SF demonstrated resilience at the community level via increased flower survival (PF) and rapid flower production (SF). Reduced species richness of NF resources in SF will compromise future resilience and response to disturbance, including for threatened pteropodid bat species. These findings are critical for long‐term management of forests, given predicted increases in cyclone frequency and intensity associated with anthropogenic climate change.
The Mental health Master Class: An innovative approach to improving student learning in mental health nursing
Authors: Ward Louise , Barry Sinead 
Published: February 2018

AbstractThe Master Class was developed as an additional educational innovation designed to promote learning about mental health and illness and mental health nursing as a career option to 2nd‐year undergraduate nursing students. A number of students had approached the mental health nursing academics expressing two polar views on mental health. They either expressed extreme interest in mental health nursing or significant distress and concern related to studying the core 2nd‐year subject. It was considered that the Master Class could potentially provide students with additional support. It was thought the Master Class may either consolidate their interest in mental health or relieve their stress. This article presents the findings of a pre‐ and postevaluation which was employed to explore the effectiveness of the 5‐day intensive mental health Master Class programme on student's mental health learning and their understanding of the role of a mental health nurse. The findings highlighted that prior to participating in the Master Class, there was a significant sense of uncertainty associated with perceived levels of competence required within the profession of mental health nursing. This was coupled with students expressing they wanted to disengage with the profession even before they had commenced any theory or clinical experience. The post‐Master Class findings illustrated a significant improvement in students desire to consider mental health nursing,
Porous hydroxyapatite‐bioactive glass hybrid scaffolds fabricated via ceramic honeycomb extrusion
Authors: Elbadawi Mohammed , Wally Zena J. , Reaney Ian M. 
Published: February 2018

AbstractThe successful fabrication of hydroxyapatite‐bioactive glass scaffolds using honeycomb extrusion is presented herein. Hydroxyapatite was combined with either 10 wt% stoichiometric Bioglass® (BG1), calcium‐excess Bioglass® (BG2) or canasite (CAN). For all composite materials, glass‐induced partial phase transformation of the HA into the mechanically weaker β‐tricalcium phosphate (TCP) occurred but XRD data demonstrated that BG2 exhibited a lower volume fraction of TCP than BG1. Consequently, the maximum compressive strength observed for BG1 and BG2 were 30.3 ± 3.9 and 56.7 ± 6.9 MPa, respectively, for specimens sintered at 1300°C. CAN scaffolds, in contrast, collapsed when handled when sintered below 1300°C, and thus failed. The microstructure illustrated a morphology similar to that of BG1 sintered at 1200°C, and hence a comparable compressive strength (11.4 ± 3.1 MPa). The results highlight the great potential offered by honeycomb extrusion for fabricating high‐strength porous scaffolds. The compressive strengths exceed that of commercial scaffolds, and biological tests revealed an increase in cell viability over 7 days for all hybrid scaffolds. Thus it is expected that the incorporation of 10 wt% bioactive glass will provide the added advantage of enhanced bioactivity in concert with improved mechanical stability.
Ageing effects on humoral immune responses in chronic periodontitis
Authors: Ebersole Jeffrey L. , Al‐Sabbagh Mohanad , Gonzalez Octavio A. , Dawson Dolph R. 
Published: February 2018

AbstractPeriodontal disease is a dominant global bacterial infection that increases with ageing.AimThis report focuses on host adaptive immune responses in periodontitis. While experimental models and humans diagnosed with periodontitis demonstrate an antigenic specificity for particular oral bacteria, we have a limited understanding of (i) how ageing affects the adaptive immune responses to these bacteria that chronically colonize the oral cavity for decades prior to disease expression and (ii) how the magnitude and specificity of the response interface with pathogens that emerge within the bacterial ecology during exacerbations of disease.Materials and MethodsSerum antibody levels to a group of pathogenic and commensal oral bacteria were measured in a population of individuals from 21 to 74 years of age, stratified based on clinical status of the periodontium, smoking and sex.ResultsClinical parameters were not significantly different within health, gingivitis or periodontitis groups related to age. Antibody to oral pathogens and commensals was similar in different age groups in each of the clinical categories, with no age correlation noted in the periodontitis patients.ConclusionsThe adaptive immune responses to oral bacteria that chronically colonize the oral cavity appear generally unaffected by age, but clearly are linked to the extent of disease.
Evaluation of the effect scan pattern has on the trueness and precision of six intraoral digital impression systems
Authors: Mennito Anthony S. , Evans Zachary P. , Lauer Abigail W. , Patel Ravi B. , Ludlow Mark E. , Renne Walter G. 
Published: February 2018

AbstractObjectiveClinicians have been slow to adopt digital impression technologies due possibly to perceived technique sensitivities involved in data acquisition. This research has two aims: determine whether scan pattern and sequence affects the accuracy of the three‐dimensional (3D) model created from this digital impression and to compare the 5 imaging systems with regards to their scanning accuracy for sextant impressions.Materials and MethodsSix digital intraoral impression systems were used to scan a typodont sextant with optical properties similar to natural teeth. The impressions were taken using five different scan patterns and the resulting digital models were overlayed on a master digital model to determine the accuracy of each scanner performing each scan pattern. Furthermore, regardless of scan pattern, each digital impression system was evaluated for accuracy to the other systems in this same manner.ResultsNo differences of significance were noted in the accuracy of 3D models created using six distinct scan patterns with one exception involving the CEREC Omnicam. Planmeca Planscan was determined to be the truest scanner while 3Shape Trios was determined to be the most precise for sextant impression making.ConclusionsScan pattern does not significantly affect the accuracy of the resulting digital model for sextant scanning.Clinical SignificanceCompanies who make digital impression systems often recommend a scan pattern specific for their system. However, every clinical scanning scenario is different and may require a different approach. Knowing how important scan pattern is with regards to accuracy would be helpful for guiding a growing number of practitioners who are utilizing this technology.
Color difference thresholds for computer‐simulated human Gingiva
Authors: Pérez María M. , Ghinea Razvan , Herrera Luis Javier , Carrillo F. , Ionescu Ana M. , Paravina Rade D. 
Published: February 2018

AbstractObjectiveTo determine 50:50% perceptibility threshold (PT) and 50:50% acceptability threshold (AT) for computer‐simulated samples of human gingiva using CIEDE2000 and CIELAB color difference formulas.Materials and MethodsEach of the 60 pairs of simulated human gingiva was displayed on a calibrated monitor, together with three pairs of upper central incisors of different lightness. The color of gingiva left and right from the midline was compared. A total of 30 observers (15 dentists, 15 laypersons) participated in the study. CIEDE2000 and CIELAB formulas were used to calculate the thresholds and a Takagi‐Sugeno‐Kang Fuzzy Approximation model was used as fitting procedure. Paired t‐test (α = 0.05) was used in evaluation of statistical significance of differences.ResultsThe PT and AT for CIEDE2000 and 95% confidence intervals were 1.1 [0.4, 1.7] and 2.8 [1.8, 4.0], respectively. Corresponding CIELAB values were 1.7 [0.2, 2.6] and 3.7 [2.1, 5.7]. Significant differences (P < .01) were recorded between PT and AT, between the corresponding threshold values in CIEDE2000 and CIELAB formulas as well as between dentists and laypersons.ConclusionsThe difference between the perceptibility and acceptability threshold for gingiva was statistically significant in both CIEDE2000 and CIELAB. The same was true for differences between the corresponding thresholds using two color difference formulas, and between dentists and laypersons. Visual thresholds of human gingiva were not dependent upon lightness of adjacent teeth. Overall, CIEDE2000 color difference formula provided better fit than CIELAB formula in the evaluation of color difference thresholds of human gingiva.Clinical SignificanceThe data on visual thresholds for healthy human gingiva can be used as quality control tool/guide for selection and evaluation of dental materials, interpretation of color‐related findings in clinical dentistry and research, and for standardization in dentistry. It is of particular value that this study was designed based on in‐vivo color evaluation of healthy keratinized gingiva of subjects of different ethnicities, age groups, and gender.
Will Pollution Taxes Improve Joint Ecological and Economic Efficiency of Thermal Power Industry in China?: A DEA‐Based Materials Balance Approach
Authors: Wang Ke , Mi Zhifu , Wei Yi‐Ming 
Published: February 2018

SummaryPrevious studies of the efficiency of Chinese electricity industry have been limited in providing insights regarding policy implications of inherent trade‐offs of economic and environmental outcomes. This study proposes a modified data envelopment analysis method combined with materials balance principle to estimate ecological and cost efficiency in the Chinese electricity industry. The economic cost and ecological impact of energy input reallocation strategies for improving efficiency are identified. The possible impacts of pollution taxes upon the levels of sulfur dioxide (SO2) emissions are assessed. Estimation results show that (1) both energy input costs and SO2 could be reduced through increasing technical efficiency. (2) It is possible to adjust energy input mix to attain ecological efficiency, and, correspondingly, SO2 would be reduced by 15%. (3) The Chinese electricity industry would reduce its unit cost by 9% if optimal ecological efficiency is attained and reduce its unit pollution by 13% if optimal cost efficiency is attained, implying that there are positive ecological synergy effects associated with energy cost savings and positive economic synergy effects associated with SO2 pollution reductions. (4) Estimated shadow costs of SO2 reduction are very high, suggesting that, in the short term, the Chinese electricity industry should pursue cost efficiency instead of ecological efficiency, since alternative abatement activities are less costly and some of the abatement cost could be further offset by energy input cost savings. (5) There would be no significant difference between the impacts of pollution discharge fees and pollution taxes on SO2 emissions levels because of the relatively low pollution tax rate.