bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fish Distributions and Habitat Associations in Manistee River, Michigan, Tributaries: Implications for Arctic Grayling Restoration
Authors: Goble Cameron W. , Auer Nancy A. , Huckins Casey J. , Danhoff Brian M. , Holtgren J. Marty , Ogren Stephanie A. 
Published: April 2018

Abstract
Restoration and enhancement of North American native freshwater fishes have for several decades been the subject of growing interest among fisheries biologists, natural resource managers, non-governmental organizations, and the sportfishing public. The Little River Band of Ottawa Indians (LRBOI) and the Michigan Department of Natural Resources (MDNR), along with universities and public interest groups, are re-examining the potential for re-introduction of the Arctic Grayling Thymallus arcticus, a species that has been extirpated in Michigan since the 1930s. The Manistee River, Michigan, flows through the LRBOI's reservation and once supported the last known native Arctic Grayling population in the state's Lower Peninsula. The objectives of this study were to (1) identify potential biotic limitations, such as competition and/or predation from other fish species, that may interfere with Arctic Grayling re-introduction in the Manistee River watershed; and (2) describe how instream habitat features currently relate to populations of potentially interacting species. Field surveys conducted during June–August 2012 in eight Manistee River tributaries identified suitable abiotic habitat for Arctic Grayling in 20 of 22 sampling reaches. However, high densities of Brown Trout Salmo trutta (a nonnative salmonid) may have influenced some of the habitat associations observed for Brook Trout Salvelinus fontinalis and Slimy Sculpin Cottus cognatus, two species that currently and historically co-occurred in Arctic Grayling habitats. These two species were the most abundant in river reaches with Brown Trout densities less than 0.10 fish/m2. Based on habitat conditions and Brown Trout densities, there appear to be four distinct tributary regions for which management strategies could be developed to enhance the success of Arctic Grayling re-introduction efforts. Re-introduction of Arctic Grayling in the Manistee River watershed would support LRBOI and MDNR goals for native species restoration and would provide a unique and historic angling opportunity that has been absent in Michigan for nearly 100 years.
International Continence Society best practice statement for use of sacral neuromodulation
Authors: Goldman Howard B. , Lloyd Jessica C. , Noblett Karen L. , Carey Marcus P. , Castaño Botero Juan Carlos , Gajewski Jerzy B. , Lehur Paul A. , Hassouna Magdy M. , Matzel Klaus E. , Paquette Ian M. , de Wachter Stefan , Ehlert Michael J. , Chartier‐Kastler Emmanuel , Siegel Steven W. 
Published: April 2018

AimsSacral neuromodulation (SNM) is an accepted therapy for a variety of conditions. However, despite over 20 years of experience, it remains a specialized procedure with a number of subtleties. Here we present the recommendations issued from the International Continence Society (ICS) SNM Consensus Panel.MethodsUnder the auspices of the ICS, eight urologists, three colorectal surgeons and two urogynecologists, covering a wide breadth of geographic and specialty interest representation, met in January 2017 to discuss best practices for neuromodulation. Suggestions for statements were submitted in advance and specific topics were assigned to committee members, who prepared and presented supporting data to the group, at which time each topic was discussed in depth. Best practice statements were formulated based on available data. This document was then circulated to multiple external reviewers after which final edits were made and approved by the group.ResultsThe present recommendations, based on the most relevant data available in the literature, as well as expert opinion, address a variety of specific and at times problematic issues associated with SNM. These include the use of SNM for a variety of underlying conditions, need for pre‐procedural testing, use of staged versus single‐stage procedures, screening for success during the trial phase, ideal anesthesia, device implantation, post‐procedural management, trouble‐shooting loss of device function, and future directions for research.ConclusionsThese guidelines undoubtedly constitute a reference document, which will help urologists, gynecologists, and colorectal surgeons optimize their use of SNM for refractory urinary urgency and frequency, UUI, NOR, and FI.
Accumulating Data to Optimally Predict Obesity Treatment (ADOPT) Core Measures: Environmental Domain
Authors: Saelens Brian E. , Arteaga S. Sonia , Berrigan David , Ballard Rachel M. , Gorin Amy A. , Powell‐Wiley Tiffany M. , Pratt Charlotte , Reedy Jill , Zenk Shannon N. 
Published: April 2018

BackgroundThere is growing interest in how environment is related to adults' weight and activity and eating behaviors. However, little is known about whether environmental factors are related to the individual variability seen in adults' intentional weight loss or maintenance outcomes.ObjectivesThe environmental domain subgroup of the Accumulating Data to Optimally Predict obesity Treatment (ADOPT) Core Measures Project sought to identify a parsimonious set of objective and perceived neighborhood and social environment constructs and corresponding measures to include in the assessment of response to adult weight‐loss treatment.SignificanceStarting with the home address, the environmental domain subgroup recommended for inclusion in future weight‐loss or maintenance studies constructs and measures related to walkability, perceived land use mix, food outlet accessibility (perceived and objective), perceived food availability, socioeconomics, and crime‐related safety (perceived and objective) to characterize the home neighborhood environment. The subgroup also recommended constructs and measures related to social norms (perceived and objective) and perceived support to characterize an individual's social environment. The 12 neighborhood and social environment constructs and corresponding measures provide a succinct and comprehensive set to allow for more systematic examination of the impact of environment on adults' weight loss and maintenance.
Curing mechanism, heat resistance, and anticorrosion properties of a furan/methyl phenyl silicone coating
Authors: Zhang Lei , Shi Zhen , Hu Weihong , Zhang Xin , Zhu Huibin , Zhao Guizhe , Wang Zhi 
Published: April 2018

A coating composed by methyl phenyl silicone resin (PSi) and furan resin (FR) was prepared, and its curing mechanism, heat resistance, and anticorrosion properties were investigated by Fourier transform infrared spectroscopy, thermogravimetric analysis, electrochemical test, and chemical resistance test. Aldol condensation reaction between FR and PSi occurred at below 200°C, and PSi underwent self‐multidehydrogenation at above 200°C. These curing reactions gave excellent thermal stability and anticorrosion properties. Compared with pure PSi, the blended containing lower than 20 wt% FR had better thermal properties, manifested as over 390°C of 5 wt% weight loss temperature and over 40% of char yield at 800°C. The adhesion property of cured blended system on the metal surface reached the first level which exceeded that of pure PSi coating (the third level). Furthermore, the corrosion resistances of coating in acid, alkali, and salt environments were all improved compared with those of monomeric polymer coating. The impedance of blended coating in 3.5% NaCl solution decreased with increasing FR content, which was 1.8 × 106 Ω cm2 when the FR content was 40%, being higher than that of pure PSi coating (7.12 × 105 Ω cm2). This was mainly due to the formation of a cross‐linked network structure based on Si―O―C bond and the enhanced adhesion of cured blended coating. In addition, the surface roughness of cured blended coating was below 2.0 μm, which may have a positive effect on drag reduction in real applications.
Degradation modeling and classification of mixed populations using segmental continuous hidden Markov models
Authors: Chen Zhen , Xia Tangbin , Li Yaping , Pan Ershun 
Published: April 2018

AbstractWith the market demands, the classification for highly reliable products becomes more and more significant. The degradation data can provide information about the degradation states and can be used to classify products to various classes according to the reliability attribute. In this paper, a temporal probabilistic approach, named segmental continuous hidden Markov model (SCHMM), is proposed to tackle the problem of degradation modeling and classification for mixed populations. Separate SCHMMs are built for each class of the mixed populations. The SCHMMs can directly depict the correspondence between actual degradation and the hidden states. A novel method called self‐training algorithm for the preprocessing of the original data from the mixed populations is proposed. Furthermore, the unknown parameters of the SCHMMs are estimated by the maximum likelihood method with the complete degradation data. The root mean square error of the estimated degradation value compared with the actual physical degradation value, as well as Akaike information criterion and Bayesian information criterion, is used for the evolution of the fitting accuracy and the selection of model topologies and discretization methods. Then the maximum posterior probability‐based classification criteria are developed. Degradation tests are designed for the data collection. To obtain the optimal classification policies, a cost function that consists of the degradation test cost and misclassification cost is constructed. A numerical example is used to illustrate the proposed method and demonstrate its advantages by comparing with other classification methods.
Computational Investigation of the Influence of π‐Bridge Conjugation Order of Thiophene and Thiazole Units in Triphenylamine Based Dyes in Dye‐Sensitized Solar Cells
Authors: Mandal Sudip , Vedarajan Raman , Matsumi Noriyoshi , Ramanujam Kothandaraman 
Published: April 2018

AbstractIn this study, ten triphenylamine based dyes were investigated by varying the π‐bridge size with a different order of thiophene and thiazole units to understand their potential use in dye‐sensitized solar cells (DSSCs). Geometry optimization, the energy levels and electron density of the highest occupied molecular orbital and the lowest unoccupied molecular orbital, and UV‐visible absorption spectra were calculated using density functional theory (DFT) and time‐dependent DFT (TD‐DFT) methods. The electron injection driving force, dye regeneration driving force, natural bond orbital (NBO) analysis of dye‐(TiO2)8 cluster and dye reorganization energy were calculated to predict the most suitable dyes for DSSC application. Dye 4 ((Z)‐2‐cyano‐3‐(2′‐((E)‐4‐(diphenylamino)styryl)‐[2, 5′‐bithiazol]‐4‐yl)acrylic acid) followed by Dye 6 ((Z)‐2‐cyano‐3‐(5‐(2‐((E)‐4‐(diphenylamino)styryl)thiazol‐5‐yl)thiophen‐3‐yl)acrylic acid) having two linker moieties were identified as the potential candidates.
Alkali‐Metal Promoted Chemo‐ and Regioselective Cycloisomerization Reactions to (Z)‐3‐Alkylideneisoindolin‐1‐ones: Unusual Positive Role of H2O
Authors: Tan Jie , Tong Yao , Chen Zhiyuan 
Published: April 2018

AbstractAn alkali‐metal promoted cycloisomerization reaction of 2‐alkynylbenzamides is described for the synthesis of useful (Z)‐3‐alkylideneisoindolin‐1‐one derivatives in modest to good yields and excellent chemo‐ and regioselectivity. Superstoichiometric amounts of water was found to be crucial for this reaction, and no transition‐metal salts are necessary. This synthetically green protocol proceeds efficiently with 100% atom economy and tolerates a diverse number of functional groups.
Stress alleviation strategy in cancer treatment: Insights from a mathematical model
Authors: Mpekris Fotios , Voutouri Chrysovalantis , Papageorgis Panagiotis , Stylianopoulos Triantafyllos 
Published: April 2018

AbstractTumors generate mechanical forces during growth and progression, which are able to compress blood and lymphatic vessels, reducing perfusion rates and creating hypoxia. Tumor vessels—while nourishing the tumor—are usually leaky and tortuous, which further decreases perfusion. Consequently, vessel leakiness together with vessel compression causes a uniformly elevated interstitial fluid pressure that hinder drug delivery and compromise therapeutic outcomes. To enhance treatment efficacy, stress alleviation and vascular normalization strategies have been developed to improve tumor perfusion and drug delivery. Stress alleviation strategy aim to decrease solid stress levels and reopen compressed blood vessels leading to improve perfusion and drug delivery. On the other hand, vascular normalization strategy aims to restore the abnormalities in tumor vasculature by decreasing vessel leakiness and thus enhance drug efficacy. Here, we employed a mathematical model to study the stress alleviation strategy using published experimental data and performing new experiments in mice bearing breast tumors. Specifically, we accounted for variations in tumor hydraulic conductivity, elastic modulus and swelling related to changes in extracellular matrix components induced by the anti‐fibrotic and stress alleviating drug, tranilast. We showed that alleviation of mechanical stresses in tumors reduces the tumor interstitial fluid pressure to normal levels and increases the functionality of the tumor vasculature resulted in improved drug delivery and treatment outcome. Finally, we used model predictions to show that vascular normalization can be combined with stress alleviation to further improve therapeutic outcomes.
Comparison of ice/water classification in Fram Strait from C- and L-band SAR imagery
Authors: Aldenhoff Wiebke , Heuzé Céline , Eriksson Leif E.B. 
Published: April 2018

ABSTRACTIn this paper an algorithm for ice/water classification of C- and L-band dual polarization synthetic aperture radar data is presented. A comparison of the two different frequencies is made in order to investigate the potential to improve classification results with multi-frequency data. The algorithm is based on backscatter intensities in co- and cross-polarization and autocorrelation as a texture feature. The mapping between image features and ice/water classification is made with a neural network. Accurate ice/water maps for both frequencies are produced by the algorithm and the results of two frequencies generally agree very well. Differences are found in the marginal ice zone, where the time difference between acquisitions causes motion of the ice pack. C-band reliably reproduces the outline of the ice edge, while L-band has its strengths for thin ice/calm water areas within the icepack. The classification shows good agreement with ice/water maps derived from met.no ice-charts and radiometer data from AMSR-2. Variations are found in the marginal ice zone where the generalization of the ice charts and lower accuracy of ice concentration from radiometer data introduce deviations. Usage of high-resolution dual frequency data could be beneficial for improving ice cover information for navigation and modelling.
EPISTEMIC AKRASIA AND EPISTEMIC REASONS
Authors: Daoust Marc-Kevin 
Published: April 2018

ABSTRACTIt seems that epistemically rational agents should avoid incoherent combinations of beliefs and should respond correctly to their epistemic reasons. However, some situations seem to indicate that such requirements cannot be simultaneously satisfied. In such contexts, assuming that there is no unsolvable dilemma of epistemic rationality, either (i) it could be rational that one's higher-order attitudes do not align with one's first-order attitudes or (ii) requirements such as responding correctly to epistemic reasons that agents have are not genuine rationality requirements. This result doesn't square well with plausible theoretical assumptions concerning epistemic rationality. So, how do we solve this puzzle? In this paper, I will suggest that an agent can always reason from infallible higher-order reasons. This provides a partial solution to the above puzzle.
Sociodemographic characteristics and frequency of consuming home-cooked meals and meals from out-of-home sources: cross-sectional analysis of a population-based cohort study
Authors: Mills Susanna , Adams Jean , Wrieden Wendy , White Martin , Brown Heather 
Published: April 2018

AbstractObjectiveTo identify sociodemographic characteristics associated with frequency of consuming home-cooked meals and meals from out-of-home sources.DesignCross-sectional analysis of a population-based cohort study. Frequency of consuming home-cooked meals, ready meals, takeaways and meals out were derived from a participant questionnaire. Sociodemographic characteristics regarding sex, age, ethnicity, working overtime and socio-economic status (SES; measured by household income, educational attainment, occupational status and employment status) were self-reported. Sociodemographic differences in higherv.lower meal consumption frequency were explored using logistic regression, adjusted for other key sociodemographic variables.SettingCambridgeshire, UK.SubjectsFenland Study participants (n11 326), aged 29–64 years at baseline.ResultsEating home-cooked meals more frequently was associated with being female, older, of higher SES (measured by greater educational attainment and household income) and not working overtime. Being male was associated with a higher frequency of consumption for all out-of-home meal types. Consuming takeaways more frequently was associated with lower SES (measured by lower educational attainment and household income), whereas eating out more frequently was associated with higher SES (measured by greater educational attainment and household income) and working overtime.ConclusionsSociodemographic characteristics associated with frequency of eating meals from different out-of-home sources varied according to meal source. Findings may be used to target public health policies and interventions for promoting healthier diets and dietary-related health towards people consuming home-cooked meals less frequently, such as men, those with lower educational attainment and household income, and overtime workers.
Shared effects of DISC1 disruption and elevated WNT signaling in human cerebral organoids
Authors: Srikanth Priya , Lagomarsino Valentina N. , Muratore Christina R. , Ryu Steven C. , He Amy , Taylor Walter M. , Zhou Constance , Arellano Marlise , Young-Pearse Tracy L. 
Published: April 2018

AbstractThe development of three-dimensional culture methods has allowed for the study of developing cortical morphology in human cells. This provides a new tool to study the neurodevelopmental consequences of disease-associated mutations. Here, we study the effects of isogenic DISC1 mutation in cerebral organoids. DISC1 has been implicated in psychiatric disease based on genetic studies, including its interruption by a balanced translocation that increases the risk of major mental illness. Isogenic wild-type and DISC1-disrupted human-induced pluripotent stem cells were used to generate cerebral organoids, which were then examined for morphology and gene expression. We show that DISC1-mutant cerebral organoids display disorganized structural morphology and impaired proliferation, which is phenocopied by WNT agonism and rescued by WNT antagonism. Furthermore, there are many shared changes in gene expression with DISC1 disruption and WNT agonism, including in neural progenitor and cell fate markers, regulators of neuronal migration, and interneuron markers. These shared gene expression changes suggest mechanisms for the observed morphologic dysregulation with DISC1 disruption and points to new avenues for future studies. The shared changes in three-dimensional cerebral organoid morphology and gene expression with DISC1 interruption and WNT agonism further strengthens the link between DISC1 mutation, abnormalities in WNT signaling, and neuropsychiatric disease.
Desynchronization of diurnal rhythms in bipolar disorder and borderline personality disorder
Authors: Carr Oliver , Saunders Kate E. A. , Bilderbeck Amy C. , Tsanas Athanasios , Palmius Niclas , Geddes John R. , Foster Russell , De Vos Maarten , Goodwin Guy M. 
Published: April 2018

AbstractIt has long been proposed that diurnal rhythms are disturbed in bipolar disorder (BD). Such changes are obvious in episodes of mania or depression. However, detailed study of patients between episodes has been rare and comparison with other psychiatric disorders rarer still. Our hypothesis was that evidence for desynchronization of diurnal rhythms would be evident in BD and that we could test the specificity of any effect by studying borderline personality disorder (BPD). Individuals with BD (n = 36), BPD (n = 22) and healthy volunteers (HC, n = 25) wore a portable heart rate and actigraphy device and used a smart-phone to record self-assessed mood scores 10 times per day for 1 week. Average diurnal patterns of heart rate (HR), activity and sleep were compared within and across groups. Desynchronization in the phase of diurnal rhythms of HR compared with activity were found in BPD (+3 h) and BD (+1 h), but not in HC. A clear diurnal pattern for positive mood was found in all subject groups. The coherence between negative and irritable mood and HR showed a four-cycle per day component in BD and BPD, which was not present in HC. The findings highlight marked de-synchronisation of measured diurnal function in both BD but particularly BPD and suggest an increased association with negative and irritable mood at ultradian frequencies. These findings enhance our understanding of the underlying physiological changes associated with BPD and BD, and suggest objective markers for monitoring and potential treatment targets. Improved mood stabilisation is a translational objective for management of both patient groups.
Ghrelin is a persistent biomarker for chronic stress exposure in adolescent rats and humans
Authors: Yousufzai Muhammad I. ul Akbar , Harmatz Elia S. , Shah Mohsin , Malik Muhammad O. , Goosens Ki A. 
Published: April 2018

AbstractProlonged stressor exposure in adolescence enhances the risk of developing stress-sensitive mental illnesses, including posttraumatic stress disorder (PTSD), for many years following exposure cessation, but the biological underpinnings of this long-term vulnerability are unknown. We show that severe stressor exposure increased circulating levels of the hormone acyl-ghrelin in adolescent rats for at least 130 days and in adolescent humans for at least 4.5 years. Using a rodent model of longitudinal PTSD vulnerability in which rodents with a history of stressor exposure during adolescence display enhanced fear in response to fear conditioning administered weeks after stressor exposure ends, we show that systemic delivery of a ghrelin receptor antagonist for 4 weeks surrounding stressor exposure (2 weeks during and 2 weeks following) prevented stress-enhanced fear memory. These data suggest that protracted exposure to elevated acyl-ghrelin levels mediates a persistent vulnerability to stress-enhanced fear after stressor exposure ends.