bluuebunny/crossref_metadata_2025_split huggingface dataset:
Five-Second Squeeze Testing in 333 Professional and Semiprofessional Male Ice Hockey Players: How Are Hip and Groin Symptoms, Strength, and Sporting Function Related?
Authors: Wörner Tobias , Thorborg Kristian , Eek Frida 
Published: February 2019

Background: Hip and groin problems are just as common in ice hockey as they are in soccer. The 5-second squeeze test (5SST) is a valid indicator of hip- and groin-related sporting function (self-reported function) in soccer and is suggested to be interpreted according to a “traffic light” approach in guiding the early identification and management of affected players. It is currently unknown how the 5SST relates to self-reported function and muscle strength in ice hockey players. Purpose: To investigate correlations between the 5SST result, self-reported function, and hip muscle strength in ice hockey players. A further aim was to investigate the discriminative ability of the “traffic light” approach (numeric rating scale [NRS] score: 0-2 = green, 3-5 = yellow, 6-10 = red) regarding levels of self-reported function and strength. Study Design: Cross-sectional study; Level of evidence, 3. Methods: Professional and semiprofessional male ice hockey players (N = 333) performed the 5SST and completed the Sport subscale of the Copenhagen Hip and Groin Outcome Score (HAGOS). Bilateral adduction and abduction strength was measured using handheld dynamometry. Associations were estimated using Spearman rank-order correlations, and groups were compared using the Kruskal-Wallis test or analysis of variance. Standardized effect sizes (ESs) for differences in strength (Hedges g) and self-reported function ( r) were provided. Results: The 5SST result was significantly correlated with self-reported function (rho, –0.319; P < .01) and hip muscle strength (rho, –0.157 to –0.305; P < .01). The HAGOS Sport scores differed significantly between all 3 traffic light groups (ES, 0.23-0.33; P ≤ .005). Players with an NRS score >2 (yellow or red light) had lower adduction (ES ≥ 0.75; P < .001) and abduction strength (yellow: ES, 0.30; P = .031) (red: ES, 0.51; P = .058) than players with a green light. Conclusion: The 5SST result was significantly correlated with self-reported function as well as hip muscle strength and was able to discriminate between the traffic light levels in ice hockey players. Players with a yellow or red light had reduced adduction and abduction strength compared with players with a green light (NRS score ≤2). Routine 5SSTs may allow the early identification of affected ice hockey players and indicate yellow and red light situations, in which players may benefit from load management and appropriate hip muscle strengthening.
Factors Associated with Pediatric Dentists’ Choice of Amalgam: Choice-Based Conjoint Analysis Approach
Authors: Bakhurji E. , Scott T. , Sohn W. 
Published: February 2019

Background: The Minamata treaty (2013) enacted a globally binding agreement to phase down amalgam use, which may significantly affect dental care for underserved populations. To comply with the Minamata treaty, strategic approaches need to be implemented to reduce amalgam use while imposing minimal risk on the dental care of the underserved. Objectives: To establish strategic approaches to reduce amalgam use, the aim of this study is to use a marketing research analysis to determine which patient-related factors influence pediatric dentists’ choice of amalgam. Methods: A survey containing questions regarding amalgam use, perception about the environmental impact of amalgam waste, and hypothetical clinical scenarios of a child with dental caries with varying levels of caries risk and types of dental insurance was developed and pretested. Emails linked to an electronic survey were sent via Qualtrics to all active American Academy of Pediatric Dentistry members ( n = 5,101), followed by 3 reminders. Descriptive analysis and choice-based conjoint analysis were performed to investigate trade-offs between selected factors, using SAS version 9.3. Results: Of 892 (17.6%) replies, 850 responses were eligible for analysis. Only 385 (45%) respondents indicated using amalgam, and their responses were analyzed in the conjoint model. Respondents’ selection of amalgam varied between 8% and 28% across all the clinical scenarios, with most respondents choosing composite or stainless steel crowns. Conjoint analysis revealed that, while both caries risk and type of insurance affected respondents’ decision about amalgam use, caries risk was the driving factor in decision-making for using amalgam. Conclusion: These results underscore the importance of prevention and management of risk factors to successfully phase down amalgam use. Knowledge Transfer Statement: Our study applied the marketing research tool, choice-based conjoint analysis, to investigate the relative importance of different factors on dentists’ decision-making regarding amalgam use. This study should be of great interest to policy makers when developing strategic approaches to comply with the 2013 United Nations Environment Programme (a.k.a. Minamata treaty) policy recommendations for phase-down of dental amalgam.
Acute treatment of migraine with external trigeminal nerve stimulation: A pilot trial
Authors: Kuruvilla Deena , Mann Joseph I , Schoenen Jean , Penning Sophie 
Published: February 2019

Objective: The main objective of this study was to obtain efficacy data for external trigeminal nerve stimulation (e-TNS) in the acute treatment of migraine in patients using the device at home. Methods: This was a single-center, open-label trial conducted at the Rochester Clinical Research Center (Rochester, NY, USA). Patients who met International Classification of Headache Disorders, Third Edition, criteria for migraine with and without aura for ≥1 year and having between 2 and 8 moderate or severe attacks per month were recruited. Patients were advised to treat one migraine attack of moderate to severe intensity that started less than 4 h earlier and was not treated with an acute migraine medication, with a 2-h e-TNS session. Primary outcome measures were pain freedom at 2 h and most bothersome migraine-associated symptom (MBS) freedom at 2 h. Secondary outcome measures were pain relief at 2 h, the absence of migraine-associated symptoms at 2 h, the use of rescue medication between 2 and 24 h, and sustained pain freedom at 24 h. Results: Fifty-nine subjects were included in the study, and among them, 48 subjects were eligible for the modified intention-to-treat analysis. After 2 h of e-TNS, 35.4% of the subjects were pain-free, 60.4% were MBS-free, 70.8% had pain relief, and 45.8% were free from all migraine-associated symptoms. Half of the subjects took rescue medication between 2 h and 24 h, and sustained pain freedom at 24 h was achieved for 25.0% of the subjects. Regarding safety, 15 patients reported adverse events, all minor and fully reversible, mainly forehead paresthesia. Conclusions: This study shows that e-TNS with the Cefaly® Acute Device is effective, well-tolerated, and safe for the acute treatment of migraine in patients using the device at home. A large, multicenter, randomized, sham-controlled trial is needed to confirm this finding.
Clinical profile of SUNCT/SUNA in Japan: A clinic-based study
Authors: Kikui Shoji , Miyahara Junichi , Sugiyama Hanako , Yamakawa Kentaro , Kashiwaya Yoshihiro , Ishizaki Kumiko , Danno Daisuke , Takeshima Takao 
Published: February 2019

Objectives: This study aimed to report the clinical profiles of patients with short-lasting unilateral neuralgiform headache attacks with conjunctival injection and tearing (SUNCT)/short-lasting unilateral neuralgiform headache attacks with cranial autonomic (SUNA) in a Japanese population by surveying those enrolled at a regional headache center in Japan. Methods: In this consecutive case series study, the clinical characteristics of patients with SUNCT (eight men, three women; mean age: 59.5 ± 20.5 years) and SUNA (five men, four women; mean age: 51.3 ± 18.4 years) who visited Tominaga Hospital from February 2011 to January 2017 were examined. Headaches were diagnosed according to the International Classification of Headache Disorders, Third edition (ICHD-3) guidelines. Results: Brief clusters of separate attacks were reported by all patients. The mean duration of attacks was 91.9 ± 87.9 s. Ipsilateral rhinorrhea was observed in 9 of 20 (45.0%) cases and facial sweating was observed in 1 of 20 (5.0%) cases. An eminent response to lamotrigine was observed in 9 of 9 (100%) patients; however, adverse events were only reported in 2 of 9 (22.2%) cases. An intravenous infusion of lidocaine was demonstrated to be completely successful for short-term prevention in 5 of 6 (83.3%) SUNCT cases. Conclusions: Lamotrigine can successfully treat most patients, and intravenous lidocaine is useful for the short-term preventive therapy of severe recalcitrant attacks in Japanese patients with SUNCT/SUNA.
ELMO1 deficiency enhances platelet function
Authors: Patel Akruti , Kostyak John , Dangelmaier Carol , Badolia Rachit , Bhavanasi Dheeraj , Aslan Joseph E. , Merali Salim , Kim Soochong , Eble Johannes A. , Goldfinger Lawrence , Kunapuli Satya 
Published: February 2019

Abstract
Phosphatidylinositol 3-kinase is an important signaling molecule that, once activated, leads to the generation of phosphatidylinositol (3,4,5)-trisphosphate (PIP3). We performed a proteomic screen to identify PIP3-interacting proteins in human platelets. Among these proteins, we found engulfment and cell motility 1 (ELMO1), a scaffold protein with no catalytic activity. ELMO1 is expressed in platelets and interacts with active RhoG. However, the function of ELMO1 in platelets is not known. The focus of this study was to determine the function of ELMO1 in platelets utilizing ELMO1−/− mice. Platelet aggregation, granule secretion, integrin αIIbβ3 activation, and thromboxane generation were enhanced in ELMO1−/− platelets in response to glycoprotein VI (GPVI) agonists but unaltered when a protease-activated receptor 4 agonist was used. The kinetics of spreading on immobilized fibrinogen was enhanced in ELMO1−/− platelets compared with wild-type (WT) littermate controls. This suggests that ELMO1 plays a role downstream of the GPVI and integrin αIIbβ3 pathway. Furthermore, whole blood from ELMO1−/− mice perfused over collagen exhibited enhanced thrombus formation compared with WT littermate controls. ELMO1−/− mice showed reduced survival compared with control following pulmonary embolism. ELMO1−/− mice also exhibited a shorter time to occlusion using the ferric-chloride injury model and reduced bleeding times compared with WT littermate controls. These results indicate that ELMO1 plays an important role in hemostasis and thrombosis in vivo. RhoG activity was enhanced in ELMO1−/− murine platelets compared with WT littermate controls in response to GPVI agonist. Together, these data suggest that ELMO1 negatively regulates GPVI-mediated thrombus formation via RhoG.
Effects of a health educational intervention on malaria knowledge, motivation, and behavioural skills: a randomized controlled trial
Authors: Balami Ahmed Dahiru , Said Salmiah Md , Zulkefli Nor Afiah Mohd , Bachok Norsa’adah , Audu Bala 
Published: February 2019

Abstract
Background
The levels of insecticide-treated net use among pregnant women and uptake of intermittent preventive treatment in pregnancy, have been sub-optimal in Nigeria. Previous studies have reported positive correlations between knowledge, attitude and practice of malaria preventive measures. It has also been reported that information and motivation, act through a mediator (behavioural skills), to cause a health behaviour change. The aim of this study was as such to develop, implement, and assess the effects of a health educational intervention based on the information–motivation–behavioural skills (IMB) model on the levels of knowledge, motivation, and behavioural skills for ITN use and IPTp uptake among pregnant women in a hospital in north-eastern Nigeria.

Methods
This was a randomized controlled parallel-group trial in which 372 antenatal care attendees were randomly assigned to either an intervention or control group after collecting baseline data using a structured questionnaire. The intervention group received a 4-h health education on malaria, guided by a module developed based on the IMB theory, while the control group received health education on breastfeeding for a similar duration and by the same facilitator. Follow-up data were subsequently collected at 2 months and at 4 months post-intervention using the same questionnaire. The generalized linear mixed models analysis was used to determine the between-group and within-group effects of the intervention. The intention-to-treat analysis was used after missing data had been replaced. This was followed by a sensitivity analysis, where the analyses were repeated without replacing the missing values.

Results
The intervention was significant in achieving a 12.75% (p < 0.001), 8.55% (p < 0.001), and 6.350% (p < 0.001) higher total knowledge, motivation, and behavioural skills scores respectively, for the intervention group over the control group. The sensitivity analysis revealed no great differences in the effect sizes, even when missing data were not replaced.

Conclusion
The intervention module was effective in improving knowledge, motivation and behavioural skills. It is as such recommended to be adopted and incorporated into the routine antenatal health education schedules. It is also recommended that booster doses of the module be given say 2 months after the first dose to sustain levels of motivation and behavioural skills.
Trial registration Pan African Clinical Trial Registry, PACTR201610001823405. Registered 26 October 2016, http://www.pactr.org
RETRACTED ARTICLE: An empirical study on the relationship between China’s financial development and economic growth based on sensor technology
Authors: Wang Aidong 
Published: February 2019

AbstractSince the reform and opening up, China’s economic growth and financial development have made remarkable achievements. Based on the macroeconomic data from 1992 to 2012, this paper studies the relationship between China’s financial development and economic growth from the perspective of empirical analysis. Based on the value at risk model, Granger causality test is carried out on the variables of financial development and economic growth to analyze the relationship of interaction. A vector error correction model is established to estimate the parameters of each variable. The interaction between variables is further analyzed. The conclusion is that there is a mutual promotion mechanism between finance and economy in China, and economic growth can significantly promote the level of financial deepening.
The Islamic faith and best interests
Authors: Two Jessica , Curtice Martin 
Published: February 2019

SummaryThis article reviews a 2017 Court of Protection case which assessed and decided issues relating to the Islamic faith and the Mental Capacity Act 2005. The case involved a 39-year-old Muslim man with learning difficulties. It centred on his ability to make decisions about two specific aspects of his faith – capacity for fasting and for the removal of pubic and axillary hair. The judgment describes how s.4 of the Act was applied in deciding these decisions under the doctrine of best interests. In doing so, it elucidates key principles which can be applied to similar cases of this and other faiths.Declaration of interestNone.
Dietary intake of people with severe mental illness: systematic review and meta-analysis
Authors: Teasdale Scott B. , Ward Philip B. , Samaras Katherine , Firth Joseph , Stubbs Brendon , Tripodi Elise , Burrows Tracy L. 
Published: February 2019

BackgroundSevere mental illness (SMI) is thought to be associated with lower diet quality and adverse eating behaviours contributing towards physical health disparities. A rigorous review of the studies looking at dietary intake in psychotic disorders and bipolar disorder is lacking.AimsTo conduct a systematic, comprehensive evaluation of the published research on dietary intake in psychotic disorders and bipolar disorder.MethodSix electronic databases were searched for studies reporting on dietary intakes in psychotic disorders and bipolar disorder. Dietary-assessment methods, and dietary intakes, were systematically reviewed. Where possible, data was pooled for meta-analysis and compared with healthy controls.ResultsIn total, 58 eligible studies were identified. People with SMI were found to have significantly higher dietary energy (mean difference 1332 kJ, 95% CI 487–2178 kJ/day, P = 0.002, g = 0.463) and sodium (mean difference 322 mg, 95% CI 174–490 mg, P < 0.001, g = 0.414) intake compared with controls. Qualitative synthesis suggested that higher energy and sodium intakes were associated with poorer diet quality and eating patterns.ConclusionsThese dietary components should be key targets for preventative interventions to improve weight and other physical health outcomes in people with SMI.Declaration of interestS.B.T. and E.T. have clinical dietitian appointments within the South Eastern Sydney Local Health District and do not receive any further funding.
LC3-associated phagocytosis at a glance
Authors: Heckmann Bradlee L. , Green Douglas R. 
Published: February 2019

ABSTRACT
Classically, canonical autophagy has been considered a survival mechanism initiated in response to nutrient insufficiency. We now understand that autophagy functions in multiple scenarios where it is necessary to maintain homeostasis. Recent evidence has established that a variety of non-canonical functions for autophagy proteins are mechanistically and functionally distinct from autophagy. LC3-associated phagocytosis (LAP) is one such novel function for autophagy proteins and is a contributor to immune regulation and inflammatory responses across various cell and tissue types. Characterized by the conjugation of LC3 family proteins to phagosome membranes, LAP uses a portion of the canonical autophagy machinery, following ligation of surface receptors that recognize a variety of cargos including pathogens, dying cells, soluble ligands and protein aggregates. However, instead of affecting canonical autophagy, manipulation of the LAP pathway in vivo alters immune activation and inflammatory responses. In this Cell Science at a Glance article and the accompanying poster, we detail the divergence of this distinctive mechanism from that of canonical autophagy by comparing and contrasting shared and unique components of each pathway.
Collusion by Algorithm: Does Better Demand Prediction Facilitate Coordination Between Sellers?
Authors: Miklós-Thal Jeanine , Tucker Catherine 
Published: February 2019

We build a game-theoretic model to examine how better demand forecasting resulting from algorithms, machine learning, and artificial intelligence affects the sustainability of collusion in an industry. We find that, although better forecasting allows colluding firms to better tailor prices to demand conditions, it also increases each firm’s temptation to deviate to a lower price in time periods of high predicted demand. Overall, our research suggests that, despite concerns expressed by policy makers, better forecasting and algorithms can lead to lower prices and higher consumer surplus. This paper was accepted by Joshua Gans, business strategy.
Enteral nutrition and dietary modification in adult and paediatric Crohn's disease: a systematic review
Authors: Franqui Nicole R , Hewlings Susan J 
Published: February 2019

Background: Crohn's disease (CD) is an inflammatory bowel disease (IBD) that causes exacerbations of inflammation in the gastrointestinal tract, with secondary symptoms including malnutrition and weight loss. Its aetiology is related to genetics, the intestinal microbiome and environmental factors, and treatment aims to manage symptoms and induce remission. Aims: This systematic literature review considers the evidence for common dietary modifications and nutritional support for both adult and paediatric CD patients. Methods: PubMed and Google Scholar were searched for randomised control trials or others relating to diet and nutritional interventions in CD patients. Results: Eight articles were selected that met inclusion criteria. There was some limited evidence for the use in adults of low-FODMAP, gluten-free, IgG4-guided exclusion, low-residue, paleo and specific-carbohydrate diets. Only the specific-carbohydrate diet was studied in children. Partial and exclusive enteral nutrition were effective interventions in both populations, though more commonly used in children. Conclusion: In paediatric patients, enteral nutrition is the preferred treatment for severe CD. In adult CD, IgG4-exclusion diets are particularly likely to help induce remission. More research is needed before any conclusive recommendations can be made.
Considering culture and ethnicity in family-centred dementia care at the end of life: a case study
Authors: Mountford Wendy , Dening Karen Harrison 
Published: February 2019

Background: The UK older population is becoming increasingly ethnically diverse, with a projected eight-fold increase in dementia among black, Asian and minority ethnic communities over the next 30 years, compared with a two-fold increase in white British people with dementia. Aims: This Admiral Nurse case study explores an understanding of culture and ethnic background in families' experiences of dementia and caring using a culturagram assessment framework. Findings: The culturagram enabled a more comprehensive assessment, so that care delivery was sensitive to the specific cultural and ethnicity issues in a relationship-centred approach to dementia care. Conclusion: An understanding of the cultural influences in light of a diagnosis of dementia were essential in developing a care package that met the needs of all family members.
Hospice UK National Conference 2018
Authors: Bleakley Tracey , Richardson Heather , O'Leary Shaun , Scates Caroline , Dening Karen Harrison , Harrison Kerry 
Published: February 2019

Foreword Hospice UK's annual conference is the national hospice and palliative care charity's flagship event, bringing together everyone involved in leading hospice, palliative and end-of-life care for adults, children and young people. In 2018, the conference spanned two days and was held at the International Centre in Telford, Shropshire. Its theme was Transforming Palliative Care and it provided a unique forum for delegates to discuss current and forthcoming issues facing the hospice and palliative care community, and to discover new ways of thinking from outside of the sector. Packed with stimulating plenary and parallel sessions, and opportunities to network with peers and meet major providers of services and products, the conference combined high-level strategic thinking, application into practice and lessons from real-world examples. More than 800 delegates from across the hospice voluntary sector, the NHS and academia attended the conference. They included a wide cross-section of people from the hospice and palliative care sector, such as chief executives, trustees, clinical directors, nurses and doctors, as well as senior staff working in income generation, communication, operations and HR. Leaders of NHS hospices, hospitals and other care providers also attended the event.