bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparison between conventional and comprehensive sequencing approaches for genetic diagnosis of Alport syndrome
Authors: Yamamura Tomohiko , Nozu Kandai , Minamikawa Shogo , Horinouchi Tomoko , Sakakibara Nana , Nagano China , Aoto Yuya , Ishiko Shinya , Nakanishi Koichi , Shima Yuko , Nagase Hiroaki , Rossanti Rini , Ye Ming J. , Nozu Yoshimi , Ishimori Shingo , Morisada Naoya , Kaito Hiroshi , Iijima Kazumoto 
Published: July 2019

AbstractBackgroundAlport syndrome (AS) is a hereditary disease caused by mutations in COL4A3‐5 genes. Recently, comprehensive genetic analysis has become the first‐line diagnostic tool for AS. However, no reports comparing mutation identification rates between conventional sequencing and comprehensive screening have been published.MethodsIn this study, 441 patients clinically suspected of having AS were divided into two groups and compared. The initial mutational analysis method involved targeted exome sequencing using next‐generation sequencing (NGS) (n = 147, NGS group) or Sanger sequencing for COL4A3/COL4A4/COL4A5 (n = 294, Sanger group).ResultsIn the NGS group, 126 patients (86%) were diagnosed with AS by NGS, while two had pathogenic mutations in other genes, NPHS1 and EYA1. Further, 239 patients (81%) were diagnosed with AS by initial analysis in the Sanger group. Thirteen patients who were negative for mutation detection in the Sanger group were analyzed by NGS; three were diagnosed with AS. Two had mutations in CLCN5 or LAMB2. The final variant detection rate was 90%.DiscussionOur results reveal that Sanger sequencing and targeted exome sequencing have high diagnostic ability. NGS also has the advantage of detecting other inherited kidney diseases and pathogenic mutations missed by Sanger sequencing.
Thermal lensing measurements of Ti: sapphire crystal by an optical wavefront sensor
Authors: Hussain Mukhtar , Imran Tayyab , Börzsönyi Ádám 
Published: July 2019

AbstractThe effects of thermal lensing appear to be dominant in lasing crystals as the power of optical pump pulses increases. This instigates the confined heating effects in crystals. The nonuniform distributions of temperature lead to the variability of spatial refractive index in the lasing crystals and consequently, the thermal effects become prominent. The thermal effects of Brewster‐cut Ti: sapphire crystal are measured in this study. The Ti: sapphire crystal is seeded at a wavelength of 800 nm of energy ∼7 nJ and pulse duration of ∼8 fs and pumped by the 25‐ps pulses at 532 nm operating at 80 MHz. The effects of thermal lensing at ∼40 and 293 K are measured as a function of average pump power which is controlled by the automatic attenuator. The measurements of wavefronts and aberration effects are carried out by using the Shack‐Hartmann optical wavefront sensor (HASO4). This study could pave a way to suppress the thermal lensing effects at a high repetition rate laser system and to correct the wavefront aberration for ultrahigh‐intensity and metrology experiments.
Retracted: Factors Influencing Angler Satisfaction and Catch Rates in Arizona Stream Put-and-Take Trout Fisheries
Authors: Beard Zachary S. , Mann Ryan D. 
Published: July 2019

Abstract
The following article has been retracted by agreement between the authors, Zachary S. Beard and Ryan D. Mann, the journal editor-in-chief, Daniel J. Daugherty, and the American Fisheries Society:
“Factors Influencing Angler Satisfaction and Catch Rates in Arizona Stream Put-and-Take Trout Fisheries,” by Zachary S. Beard and Ryan D. Mann, Early View. DOI: https://10.1002/nafm.10322.
The retraction has been agreed to due to unattributed overlap between this article and the following article published in the North American Journal of Fisheries Management:
Volume 34(5), October 2014: “Effect of Fishing Success on Angler Satisfaction on a Central Oregon Rainbow Trout Fishery: Implications for Establishing Management Objectives,” by Joshua L. McCormick and Timothy K. Porter, pages 938–944. DOI: https://10.1080/02755947.2014.932869.
Does interpersonal dependency affect therapeutic outcome? A meta‐analytic review
Authors: Kane Fallon A. , Bornstein Robert F. 
Published: July 2019

AbstractThis study examined whether interpersonal dependency affects therapeutic outcome, using meta‐analytic techniques to synthesize results from 31 studies (49 effect sizes; overall N = 3807). High levels of dependency were associated with more positive outcome in psychodynamic therapy (r = 0.11, p < 0.05), but not cognitive‐behavioural therapy (r = −0.05, ns), and were associated with a less positive outcome in pharmacological treatment (r = −0.15, p < 0.001). Other predictors of outcome included patient diagnosis (high levels of dependency were linked with more positive outcome for patients with anxiety disorders but not those with depression), outcome measure (high levels of dependency were associated with significantly greater improvement in global functioning but not symptom reduction) and dependency measure (cognitive and cognitive‐behavioural dependency scales yielded less positive results than other types of measures). These results contribute to a growing body of literature examining effects of personality on treatment process and outcome. © 2019 John Wiley & Sons, Ltd.
Impact of different diols/polyols on the phase separation behavior as well as thermodynamic properties of tween 80
Authors: Mishu Afroja Akter , Amin Md. Ruhul , Rub Malik Abdul , Hoque Md. Anamul , Kabir Shariff E. , Asiri Abdullah M. 
Published: July 2019

AbstractHerein, the cloud points (CPs) of tween 80 (Tw 80) in water/(water + diols [ethanediol, propanediol, and butanediol])/(water + polyols [glucose, fructose, and sorbitol]) systems were measured. For diols‐Tw 80‐water system and polyols‐Tw 80‐water system, the CP values were obtained to reduce gradually with increasing content of diols and polyols at a particular concentration of Tw 80. For a certain concentration of Tw 80 having different contents of diols, the observed ∆H0c, as well as ∆S0c values, were negative over the range of concentration of diols studied, and the negative values of ∆H0c and ∆S0c were reduced with the enhancement of the content of diols. The values of ∆H0c were negative, which indicate the process was exothermic. The clouding process of Tw 80 in the presence of different diols is mainly enthalpy‐controlled process, while the contributions of enthalpy tend to reduce with enhancing of the contribution of diols. In the case of polyols‐Tw 80 mixture in an aqueous environment, the ∆Gc0 values were achieved positive. The values of ∆Hc0 and ∆Sco were obtained negative for studied systems, while the negative values reduce with enhancing of polyol (glucose and fructose) concentrations. For sorbitol‐Tw 80 system, the values of ∆Hc0 were observed to be negative and the negative magnitudes reduce with enhancing of sorbitol concentrations. The thermodynamic parameters of transfer are also evaluated and illustrated in detail.
Fear of cancer recurrence across the survivorship trajectory: Results from a survey of adult long‐term cancer survivors
Authors: Götze Heide , Taubenheim Sabine , Dietz Andreas , Lordick Florian , Mehnert‐Theuerkauf Anja 
Published: July 2019

AbstractObjectiveOur study analysed fear of cancer recurrence (FoR) in long‐term cancer survivors in relation to medical variables, depression, anxiety, and quality of life.MethodsWe present data obtained from 1,002 cancer survivors (53% male, mean age=68 years, 26% prostate cancer, 22% breast cancer) across all cancer types 5 (N=660) and 10 (N=342) years after diagnosis, who were recruited via a large Clinical Cancer Registry in Germany in a cross‐sectional study. FoR, depression, and anxiety were measured using validated self‐report questionnaires (12‐item short version of the Fear of Progression Questionnaire [FoP‐Q‐SF], Patient Health Questionnaire‐9 [PHQ‐9[, and General Anxiety Disorder‐7 [GAD‐7]). Hierarchical regression models were carried out with FoR as dependent variable and time since diagnosis as control variable.ResultsWe found high FoR‐values in 17% of the cancer survivors (FoP‐Q‐SF total score>33). FoR was higher in the 5‐year cohort (P=.028, d=0.153). Cancer survivors were most worried about the future of the family; they report being nervous prior to doctor's appointment and being afraid of relying on strangers help. Higher FoR was related to female gender (Beta=.149, P<.001), younger age (Beta=‐.103, P<.001), low social (Beta=‐.129, P<.001) and emotional functioning (Beta=‐.269, P<.001), received hormone therapy (P=.025, d=0.056), and high anxiety levels (Beta=.227, P<.001).ConclusionsEven though FoR declines slightly over time, it is still a common mental health problem for long‐term survivors even 10 years after cancer diagnosis. Since FoR is associated with reduced emotional and social quality of life, patients who are at greater risk of experiencing FoR must be identified and supported. Particularly at risk are younger women who received hormone therapy.
Adaptations to cognitive problems reported by breast cancer survivors seeking cognitive rehabilitation: A qualitative study
Authors: Green Heather J. , Mihuta Mary E. , Ownsworth Tamara , Dhillon Haryana M. , Tefay Merilyn , Sanmugarajah Jasotha , Tuffaha Haitham W. , Ng Shu‐Kay , Shum David H.K. 
Published: July 2019

AbstractObjectiveQualitative studies have elucidated cancer survivors' experiences of cognitive changes associated with cancer and cancer treatment. This study specifically explored experiences of women treated for breast cancer who were seeking cognitive rehabilitation. The objective was to characterise the frequency and nature of cognitive changes and adaptations to cognitive change reported by these participants to better understand treatment needs of this group.MethodAustralian women who had completed primary treatments for breast cancer (surgery, chemotherapy, and/or radiotherapy) and volunteered to participate in one of two cognitive rehabilitation intervention studies were interviewed via telephone. Interview responses regarding cognitive changes and adaptations to cognitive change were transcribed by the interviewers, then coded and analysed by two researchers using content analysis.ResultsAmong the 95 participants (age M=54.3 years, SD=9.6), the most commonly reported cognitive change was memory (79% of participants) and 61% reported more than one type of cognitive change. Adaptations to change were reported by 87% of participants, with written or electronic cues the most common (51%). Most often, participants reported using a single type of adaptation (48%) with only 39% reporting multiple types of adaptations.ConclusionsWomen treated for breast cancer, who were seeking cognitive rehabilitation, most commonly reported memory changes, which were mainly managed through a single type of adaptation. These results suggest that there is considerable scope for increasing the range of cognitive adaptations to improve the quality of life of cancer survivors who experience adverse cognitive changes.
Using the novel HiBiT tag to label cell surface relaxin receptors for BRET proximity analysis
Authors: Hoare Bradley L. , Kocan Martina , Bruell Shoni , Scott Daniel J. , Bathgate Ross A. D. 
Published: July 2019

AbstractRelaxin family peptide 1 (RXFP1) is the receptor for relaxin a peptide hormone with important therapeutic potential. Like many G protein‐coupled receptors (GPCRs), RXFP1 has been reported to form homodimers. Given the complex activation mechanism of RXFP1 by relaxin, we wondered whether homodimerization may be explicitly required for receptor activation, and therefore sought to determine if there is any relaxin‐dependent change in RXFP1 proximity at the cell surface. Bioluminescence resonance energy transfer (BRET) between recombinantly tagged receptors is often used in GPCR proximity studies. RXFP1 targets poorly to the cell surface when overexpressed in cell lines, with the majority of the receptor proteins sequestered within the cell. Thus, any relaxin‐induced changes in RXFP1 proximity at the cell surface may be obscured by BRET signal originating from intracellular compartments. We therefore, utilized the newly developed split luciferase system called HiBiT to specifically label the extracellular terminus of cell surface RXFP1 receptors in combination with mCitrine‐tagged receptors, using the GABAB heterodimer as a positive control. This demonstrated that the BRET signal detected from RXFP1‐RXFP1 proximity at the cell surface does not appear to be due to stable physical interactions. The fact that there is also no relaxin‐mediated change in RXFP1‐RXFP1 proximity at the cell surface further supports these conclusions. This work provides a basis by which cell surface GPCR proximity and expression levels can be specifically studied using a facile and homogeneous labeling technique such as HiBiT.
A Correlation between Iodoplumbate and Photovoltaic Performance of Perovskite Solar Cells Observed by Precursor Solution Aging
Authors: Shin Gwang Su , Kim Seul‐Gi , Zhang Yong , Park Nam‐Gyu 
Published: July 2019

AbstractThis study reports the aging effect of a perovskite precursor solution on the photovoltaic performance of perovskite solar cells. The precursor solution is aged at different temperatures of 4, 25 (room temperature), and 65 °C. Power conversion efficiency (PCE) is found to depend on the aging condition. Average PCE increases with aging time, where optimal aging time for best the PCE decreases with aging temperature. Average PCE of 17.29% obtained from a 24 h aged solution at 4 °C is higher than that of 16.48% from a nonaged fresh solution. At 25 °C, a 2–4 h aged solution yields highest PCE of 17.41%. The aging effect is more accelerated at 65 °C, where the best PCE of around 17.10% is achieved from the solution aged for 1.5–2 h. It is commonly observed that photocurrent density is substantially influenced by aging time, while voltage is less affected. Fill factor declines with aging time regardless of aging temperature. Iodoplumbate PbI2S4 (S = solvent) formed in the precursor solution increases its concentration, as aging time increases at a given temperature, which is beneficial for improving photovoltaic performance. No aging effect is found for excess MAI or PbI2 due to initially formed sufficient iodoplumbate.
Durability of pretensioned concrete girders in coastal climate bridges: Basis for better maintenance and future design
Authors: Osmolska Magdalena J. , Kanstad Terje , Hendriks Max A. N. , Hornbostel Karla , Markeset Gro 
Published: July 2019

AbstractThis study was based on findings from the Norwegian Public Roads Administration's Bridge Management System and field investigations on corrosion damage in pretensioned Norwegian standard I‐beam (NIB) girders in 227 coastal climate bridges. The main durability design parameters are summarized and related to regulations over the last 80 years. Environmental exposure is discussed in the light of the global, local, and micro climate. We found that 51% of the bridges have girder corrosion damage. The percentage is highest for bridges built when the cover thickness required was lowest. Cover thickness below that required (resulting from production faults) caused 74% of corrosion damage. Most of the severe chloride‐induced corrosion damage in bridges was found in the inner NIB girders, particularly in the support‐zones and their vicinity. This can be due to interaction between geometry and exposure. Corrosion of reinforcement in support‐zones can impact structural behavior, particularly NIB girder shear performance.
Non‐invasive cell‐free fetal DNA testing for aneuploidy: multicenter study of 31 515 singleton pregnancies in southeastern China
Authors: Xu L. , Huang H. , Lin N. , Wang Y. , He D. , Zhang M. , Chen M. , Chen L. , Lin Y. 
Published: July 2019

ABSTRACTObjectiveTo analyze the non‐invasive prenatal testing (NIPT) for aneuploidy results of 31 515 singleton pregnancies in Fujian province, southeastern China, and assess its performance in low‐, moderate‐ and high‐risk pregnancies.MethodsWomen were categorized into groups according to whether their risk for fetal abnormality was low, moderate or high. Cell‐free plasma DNA extracted from peripheral blood samples was subjected to low‐coverage whole‐genome sequencing. Standard Z‐score analysis of the mapped sequencing reads was used to identify fetal aneuploidy, including the three main trisomies (T21, T18 and T13) and sex chromosome aneuploidy (SCA). NIPT‐positive results were confirmed by amniocentesis and karyotyping. The performance of NIPT for detection of T21, T18, T13 and SCA was assessed by calculating the sensitivity and specificity.ResultsThe rate of chromosomal abnormality detected by NIPT in the study population was 1.38%. A higher rate of chromosomal abnormality was found in the high‐risk group (1.57%) compared to the moderate‐risk (1.05%) and low‐risk (1.18%) groups (P < 0.05). Sensitivity and specificity, respectively, were 98.96% (95/96) and 99.94% (31 274/31 292) for detection of T21, 100% (25/25) and 99.96% (31 352/31 363) for T18, 100% (7/7) and 99.97% (31 373/31 381) for T13 and 100% (61/61) and 99.74% (31 245/31 327) for SCA. Positive predictive values were high for T21 (84.07%) and T18 (69.44%) and moderate for T13 (46.67%) and SCA (42.66%).ConclusionOur findings support the application of NIPT for reliable and accurate testing of the general population of reproductive‐age women for clinically significant fetal aneuploidy. Copyright © 2019 ISUOG. Published by John Wiley & Sons Ltd.
Cultivating the next generation designers: group work in urban and regional design education
Authors: Qu Lei , Chen Yawei , Rooij Remon , de Jong Peter 
Published: July 2019

AbstractThis article contributes to the discussion about learning from group methods in design education. Based on action research results, it presents and reflects on teaching activities related to urban and regional design in TU Delft, Faculty of Architecture and the Built Environment, conducted and coordinated by the authors. Constructive alignment of the teaching triangle and feedbacks from students and teachers are used to assess the effectiveness of learning from group methods in these courses from the perspective of teaching quality. The evaluation does not aim for revealing missing components or links in theory on design education. Instead, it is using existing theories to analyse education practices, for a better understanding and performance of group work in a specific field of design education. The conclusions of the article focus on pros and cons of group work in urban and regional design education, with highlighted common challenges for teaching, such as assessment on individual performance, as well as specific ones, such as stimulating ‘out of the box thinking’ and supervising interdisciplinary groups.
Knowledge embedded
Authors: Kindermann Dirk 
Published: July 2019

AbstractHow should we account for the contextual variability of knowledge claims? Many philosophers favour an invariantist account on which such contextual variability is due entirely to pragmatic factors, leaving no interesting context-sensitivity in the semantic meaning of ‘know that.’ I reject this invariantist division of labor by arguing that pragmatic invariantists have no principled account of embedded occurrences of ‘Sknows/doesn’t know thatp’: Occurrences embedded within larger linguistic constructions such as conditional sentences, attitude verbs, expressions of probability, comparatives, and many others, I argue, give rise to a threefold problem of embedded implicatures.
Positive effect of AgNPs and AuNPs in in vitro cultures of Lavandula angustifolia Mill.
Authors: Jadczak Paula , Kulpa Danuta , Bihun Magdalena , Przewodowski Włodzimierz 
Published: July 2019

AbstractThe aim of this study was determined how an addition of gold nanoparticle (AuNPs) and silver NPs (AgNPs) into culture media affects plant development and formation of oil glands in narrow-leaved lavender (Lavandula angustifolia) cv. ‘Munstead’. Plant shoots were propagated on media supplemented with 1, 2, 5, 10, 20 and 50 mg dm−3 AuNPs or AgNPs (diameter of 24.2 ± 2.4 nm and 27.5 ± 4.8 nm). Both of NPs positively influenced the growth and development of lavender propagated in vitro. The culture media with NPs stimulated formation of shoots and increased plant weight. Roots of plants propagated on the media supplemented with NPs were usually longer than those in the control. Only high concentrations of NPs (20 and 50 mg dm−3) in the culture media were toxic to plants, as demonstrated by restricted shoot length and gradual decrease in the value of other morphological features. Increases in AgNPs concentration caused the number of secretory trichomes to decrease. The diameter of the trichomes on both sides of the leaf blade was larger when the plants were propagated on the media supplemented with 1 and 2 mg dm−3 NPs. The diameter of trichomes formed on the adaxial surface of the leaf blade was greatest in the media enriched with 2 mg dm−3 AgNPs and 5 mg dm−3 AuNPs, and smallest in the media enriched with 5 mg dm−3 AgNPs. The diameter of trichomes formed on the abaxial surface was largest in plants exposed to 1, 2, 5 and 10 mg dm−3 AuNPs, 1 mg dm−3 AgNPs, and smallest in plants exposed to 5 mg dm−3 AgNPs.
Fostering adolescent curiosity through a question brainstorming intervention
Authors: Clark Shelby , Harbaugh Allen G. , Seider Scott 
Published: July 2019

ABSTRACTIntroductionHigh adolescent curiosity is associated with several positive outcomes, yet questioning, a common behavioral manifestation of curiosity, declines once children enter formal schooling. The present quasi‐experimental study empirically investigated whether directly teaching students to question helps to foster students’ more enduring, dispositional tendency towards curiosity.MethodThe study explored the impact of a direct‐instruction student‐brainstorming intervention, the Question Formulation Technique (QFT), on adolescents' curiosity. The study's sample included adolescents (N = 3173) in four public high schools in the United States nested within 43 educators' English/Language Arts classrooms. Teachers (N = 43) were randomly assigned to two groups, one of which received professional development in the QFT in fall 2015 and the other in the winter of 2016. The study utilized student self‐report questionnaires and teacher fidelity checks at three time points (fall, winter, and spring) to consider the impact of the QFT on participating adolescents' curiosity.ResultsMultilevel modeling results indicated a positive treatment effect of the QFT on adolescents' curiosity, a positive adherence effect on adolescents' curiosity growth, and a positive dosage effect on adolescents’ curiosity growth.ConclusionsThe study suggests that adolescent dispositional curiosity can be significantly increased by directly teaching students to question.