bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Theory‐Driven Investigation of the Association Between Emotion Dysregulation and Suicide Risk in a Clinical Adolescent Sample
Authors: Eaddy Michael , Zullo Lucas , Horton Sarah E. , Hughes Jennifer L. , Kennard Betsy , Diederich Andrew , Emslie Graham J. , Schuster Lisa , Stewart Sunita M. 
Published: May 2018

ObjectiveEmotion dysregulation has been consistently linked to suicide ideation and attempt, but an explanatory model for this relationship has not been adequately investigated in adolescents. This study examined the concurrent relationship among emotion dysregulation, variables from the Interpersonal–Psychological Theory of Suicide (IPTS), and suicide risk (operationalized as a continuous variable that increases in intensity from nonspecific to active suicide ideation to suicide ideation with a plan) in a clinical adolescent sample.MethodA total of 151 adolescents (aged 12–17) were recruited from an inpatient psychiatry unit. Cross‐sectional analyses were conducted to determine whether the relationship between emotion dysregulation and suicide risk was explained by the variables of perceived burdensomeness (PB), thwarted belongingness, and capability for suicide, as proposed by the IPTS.ResultsAs hypothesized, the relationship between emotion dysregulation and suicide risk was explained by PB and capability for suicide. Depressive symptoms had an independent relationship with suicide risk after controlling for IPTS variables.ConclusionsThe results from this study suggest that effective treatment strategies that reduce negative cognition tied to PB and depressive symptoms would address the most proximal variables related to suicide risk in adolescents. Enhancing emotion management would serve to maintain low levels of proximal influences on risk.
The management of anaemia and haematinic deficiencies in pregnancy and post‐partum
Authors: Roy N. B. A. , Pavord S. 
Published: May 2018

SummaryAnaemia is one of the most common disorders in the world (24·8% of the world population) (de Benoist 2008) and affects patients of all ages and ethnic origins. Underlying causes and prevalences vary by age group and socioeconomic background, but pregnant women everywhere are at high risk of anaemia, the vast majority of cases being due to iron deficiency. One in four pregnant women in Europe are thought to have iron deficiency anaemia (Daru et al., March 2016), whereas in parts of Africa, where hookworm infestation is common, this has been estimated to be as high as 38% (Stevens et al., 2013) to 50% (Bah et al., June 2017). Women of menstruating age are rarely iron replete (Low et al., 18 April 2016) and then enter pregnancy, which carries a major negative iron balance (Bentley, October 1985). Despite a good understanding of the causes of anaemia in pregnancy, there is still uncertainty about how best this should be investigated, prevented and managed. This reflects the limitations of laboratory tests, as well as the poor understanding of how best to replace iron, given the complex physiological mechanisms of iron absorption and distribution. A strategy for iron replacement in a population of anaemic pregnant women needs to be developed not only based on what is biologically and clinically most appropriate but also in the context of each organisation's delivery of care structure, taking into consideration aspects of cost effectiveness. For this reason, management algorithms must be adapted locally, ensuring they meet basic clinical imperatives.
Bahasa gado‐gado: English in Indonesian popular texts
Authors: Martin‐Anatias Nelly 
Published: May 2018

AbstractThis study explores the relationship between language selection and identity construction in contemporary Indonesia via an examination of Indonesian popular texts published after 1998. Utilizing an interpretive textual analysis, I examine how the socio‐political situation has influenced language selection in the period following Suharto's rule (1966–1998), popularly known as theReformasiera. Whereas national identity has been heavily government‐imposed and homogenous, in large part due to governmental regulation of language use, popular texts demonstrate that Indonesian identities are in fact multi‐faceted. I shed light on language selection (bahasa gado‐gado) as a strategic mechanism of resistance toward policies and social norms that privilege monolingualism.
Time-Trial Performance in World-Class Speed Skaters After Chronic Nitrate Ingestion
Authors: Richard Philippe , Koziris Lymperis P. , Charbonneau Mathieu , Naulleau Catherine , Tremblay Jonathan , Billaut François 
Published: May 2018

Purpose: Nitrate supplementation can increase tolerance to high-intensity work rates; however, limited data exist on the recovery of performance. The authors tested whether 5 d of nitrate supplementation could improve repeated time-trial performance in speed skating. Methods: Using a double-blind, placebo-controlled, crossover design, 9 international-level short-track speed skaters ingested 1 high (juice blend, ∼6.5 mmol nitrate; HI) or low dose (juice blend, ∼1 mmol nitrate; LO) per day on days 1–4. After a double dose of either HI or LO on day 5, athletes performed 2 on-ice 1000-m time trials, separated by 35 min, to simulate competition races. Differences between HI and LO were compared with the smallest practically important difference. Results: Salivary [nitrate] and [nitrite] were higher in HI than LO before the first (nitrate: 81%, effect size [ES]: 1.76; nitrite: 72%, ES: 1.73) and second pursuits (nitrate: 81%, ES: 1.92; nitrite: 71%, ES: 1.78). However, there was no difference in performance in the first (LO: 90.92 [4.08] s; HI: 90.95 [4.06] s, ES: 0.01) or the second time trial (LO: 91.16 [4.06] s; HI: 91.55 [4.40] s, ES: 0.09). Plasma [lactate] measured after the trials (LO: 14.8 [1.1] mM; HI: 14.8 [1.2] mM, ES: 0.01) and at the end of the recovery period (LO: 9.8 [2.1] mM; HI: 10.2 [1.9] mM, ES: 0.05) was not different between treatments. Conclusion: Five days of high-dose nitrate supplementation did not change physiological responses and failed to improve single and repeated time-trial performances in world-class short-track speed skaters. These data suggest that nitrate ingestion up to 6.5 mmol does not enhance recovery from supramaximal exercise in world-class athletes.
3×3 Basketball: Performance Characteristics and Changes During Elite Tournament Competition
Authors: Montgomery Paul G. , Maloney Brendan D. 
Published: May 2018

Purpose: To determine the changes in game performance during tournament play of elite 3×3 basketball. Methods: A total of 361 men and 208 women competing in selected international tournaments had game demands assessed by wearable technology (global positioning system, inertial sensor, and heart rate) along with postgame blood lactate and perceived responses. Differences in the means for selected variables between games were compared using magnitude-based inferences and reported with effect size and associated confidence limits (CL), along with the percentage difference (ES; ±90% CL, %difference) of log-transformed data. Results: No clear differences were seen over a tournament period in PlayerLoad™ or PlayerLoad·minute−1. Tournament competition elicits variable changes between games for all inertial measures. Average peak heart rate was 198 (10) and 198 (9) beats·min−1, and average game heart rate was 164 (12) and 165 (18) beats·min−1 for men and women, respectively, with no change between games. Average game lactate was 6.3 (2.4) and 6.1 (2.2) mmol·L−1 for men and women, respectively. Average game ratings of perceived exertion were 5.7 (2.1) and 5.4 (2.0) AU for men and women, respectively. Although lactate and ratings of perceived exertion were variable between games, there was no difference over a tournament. Conclusions: The physical and physiological demands of elite 3×3 games over the duration of a tournament are similar regardless of pool or championship rounds. This may imply that maintaining technical and strategic aspects leads to success rather than minimizing fatigue through superior physical preparation. However, the physiological responses are high; caution is warranted in being underprepared for these demands in tournament play.
Time-Trial Performance in Elite Speed Skaters After Remote Ischemic Preconditioning
Authors: Richard Philippe , Billaut François 
Published: May 2018

Purpose: Speed skating leads to blood-flow restriction and deoxygenation in the lower limbs (especially the right leg) that may affect performance. Although the acute influence of such deoxygenation is not clearly understood, the authors tested whether remote ischemic preconditioning (RIPC) could modify muscular oxygenation and improve time-trial performance in that sport. Methods: Using a randomized, single-blind, placebo-controlled, crossover design, 9 elite speed skaters performed 1000-m on-ice time trials preceded by either RIPC of the upper limbs (3 × 5-min compression/5-min reperfusion cycles at 30 mm Hg >arterial systolic pressure) or placebo treatment (SHAM; 10 mm Hg). Changes in tissue saturation index, oxyhemoglobin–oxymyoglobin, deoxyhemoglobin–deoxymyoglobin, and total hemoglobin–myoglobin in the right vastus lateralis muscle were monitored using near-infrared spectroscopy (NIRS). Differences between RIPC and SHAM were analyzed using Cohen effect size (ES) ± 90% confidence limits and magnitude-based inferences. Results: Compared with SHAM, RIPC had a negligible effect on performance and NIRS variables. However, in a subgroup of sprinters (n = 5), RIPC likely lowered tissue saturation index at the beginning of the time trial (−6.1%; ES = −0.65) and likely increased deoxyhemoglobin–deoxymyoglobin at the beginning (3%; ES = 0.39), middle (2.9%; ES = 0.37), and end of the trial (−2.1%; ES = 0.27). In the middle section of the trial, these metabolic changes were concomitant with a possible increase in total hemoglobin–myoglobin. Conclusion: RIPC has no practical ergogenic impact on 1000-m long-track speed-skating performance in elite athletes. The relevance of using RIPC during training to increase physiological stress in sprinters particularly deserves further investigation.
Clinical, Radiological, and Microbiological Characteristics of Mycobacterium simiae Infection in 97 Patients
Authors: Coolen-Allou Nathalie , Touron Thomas , Belmonte Olivier , Gazaille Virgile , Andre Michel , Allyn Jérôme , Picot Sandrine , Payet Annabelle , Veziris Nicolas 
Published: May 2018

ABSTRACT

Mycobacterium simiae
is a rare species of slow-growing nontuberculous mycobacteria (NTM). From 2002 to 2017, we conducted a retrospective study that included all patients with NTM-positive respiratory samples detected in two university hospitals of the French overseas department of Reunion Island. We recorded the prevalence of
M. simiae
in this cohort, as well as the clinical, radiological, and microbiological features of patients with at least 1 sample positive for
M. simiae
. In our cohort, 97 patients (15.1%) were positive for
M. simiae
. Twenty-one patients (21.6%) met the American Thoracic Society (ATS) criteria for infection.
M. simiae
infection was associated with bronchiectasis, micronodular lesions, and weight loss. Antibiotic susceptibility testing was performed for 60 patients, and the isolates were found to have low susceptibility to antibiotics, except for amikacin, fluoroquinolones, and clarithromycin. Treatment failed for 4 of the 8 patients treated for
M. simiae
infection. Here, we describe a specific cluster corresponding to a large cohort of patients with
M. simiae
, a rare nontuberculous mycobacterium associated with low pathogenicity and poor susceptibility to antibiotics.
Validation of the health assets index in the Australian inpatient setting: a multicentre prospective cohort protocol study
Authors: Gregorevic Katherine , Hubbard Ruth E , Peel Nancye May , Lim Wen Kwang 
Published: May 2018

IntroductionIt is well known that frail older adults are at increased risk for mortality and functional decline on admission to hospital. Systematic review demonstrates that health assets are associated with improved outcomes for hospitalised older adults. The health assets index (HAI) has been developed to measure health assets in the hospital setting. A protocol has been developed to determine the predictive validity of the HAI for frail older adults.Methods and analysisThe HAI was developed based on a systematic review and secondary analysis of the interRAI-Acute Care (interRAI-AC) dataset. A pilot study was undertaken to refine the tool.The validation study will be a multicentre prospective cohort. Participants will be adults aged 70 years and older with an unplanned admission to hospital. Frailty, illness severity and demographic data will also be recorded. The primary outcomes are mortality at 28 days postdischarge and functional decline at the time of discharge from hospital. The primary hypothesis is that a higher score on the HAI will mitigate the effects of frailty for hospitalised older adults. The secondary outcomes to be recorded are length of stay, readmission at 28 days and functional status at 28 days postdischarge. The correlation between HAI and frailty will be explored. A multivariate analysis will be undertaken to determine the relationship between the HAI and the outcomes of interest.Ethics and disseminationEthical approval has been obtained from Austin Health Human High Risk Ethics Committee. The results will be disseminated in peer-reviewed journals and research conferences. This study will determine whether the HAI has predictive validity for mortality and functional decline for hospitalised, frail older adults.
Prognosis of oesophageal adenocarcinoma and squamous cell carcinoma following surgery and no surgery in a nationwide Swedish cohort study
Authors: Kauppila Joonas H , Mattsson Fredrik , Brusselaers Nele , Lagergren Jesper 
Published: May 2018

ObjectivesTo assess the recent prognostic trends in oesophageal adenocarcinoma and oesophageal squamous cell carcinoma undergoing resectional surgery and no such surgery. Additionally, risk factors for death were assessed in each of these patient groups.DesignCohort study.SettingA population-based, nationwide study in Sweden.ParticipantsAll patients diagnosed with oesophageal adenocarcinoma and oesophageal squamous cell carcinoma in Sweden from 1 January 1990 to 31 December 2013, with follow-up until 14 May 2017.Outcome measuresObserved and relative (to the background population) 1-year , 3-year and 5-year survivals were analysed using life table method. Multivariable Cox regression provided HR with 95% CI for risk factors of death.ResultsAmong 3794 patients with oesophageal adenocarcinoma and 4631 with oesophageal squamous cell carcinoma, 82% and 63% were men, respectively. From 1990–1994 to 2010–2013, the relative 5-year survival increased from 12% to 15% for oesophageal adenocarcinoma and from 9% to 12% for oesophageal squamous cell carcinoma. The corresponding survival following surgery increased from 27% to 45% in oesophageal adenocarcinoma and from 24% to 43% in oesophageal squamous cell carcinoma. In patients not undergoing surgery, the survival increased from 3% to 4% for oesophageal adenocarcinoma and from 3% to 6% for oesophageal squamous cell carcinoma. Women with oesophageal squamous cell carcinoma had better prognosis than men both following surgery (HR 0.71, 95% CI 0.61 to 0.83) and no surgery (HR 0.86, 95% CI 0.81 to 0.93).ConclusionsThe prognosis has improved over calendar time both in oesophageal adenocarcinoma and oesophageal squamous cell carcinoma in Sweden that did and did not undergo surgery. Women appear to have better prognosis in oesophageal squamous cell carcinoma than men, independent of treatment.
Cerebrospinal fluid immunoglobulin light chain ratios predict disease progression in multiple sclerosis
Authors: Rathbone Emma , Durant Lindsay , Kinsella James , Parker Antony R , Hassan-Smith Ghaniah , Douglas Michael R , Curnow S John 
Published: May 2018

ObjectiveTo determine whether the ratio of cerebrospinal fluid (CSF) immunoglobulin kappa to lambda light chains at time of multiple sclerosis (MS) diagnosis predicts disease progression and whether this was intrinsic to CSF plasmablasts.MethodsCSF and peripheral blood were obtained from patients undergoing elective diagnostic lumbar puncture and included clinically isolated syndrome (CIS) (n=43), relapsing remitting MS (RRMS; n=50), primary progressive MS (PPMS; n=20) and other neurological disease controls, both inflammatory (ONID; n=23) and non-inflammatory (OND; n=114). CSF samples were assayed for free and immunoglobulin-associated light chains and on B cells and plasmablasts. Clinical follow-up data were collected during a 5-year follow-up period where available.ResultsThere was an increased median CSF κ:λ free light chain (FLC) in all MS groups (CIS: 18.2, 95% CI 6.8 to 30.3; RRMS: 4.4, 95% CI 2.7 to 11.4; PPMS: 12.0, 95% CI 3.6 to 37.1) but not controls (OND: 1.61, 95% CI 1.4 to 1.9; ONID: 1.7, 95% CI 1.3 to 2.2; p<0.001). This ratio predicted Expanded Disability Status Scores (EDSS) progression at 5 years, with a lower median EDSS in the group with high (>10) CSF κ:λ FLC (0.0, 95% CI 0 to 2.5 vs 2.5, 95% CI 0 to 4, high vs low; p=0.049). CSF κ:λ FLC correlated with CSF IgG1 κ:λ (r=0.776; p<0.0001) and was intrinsic to CSF plasmablasts (r=0.65; p=0.026).ConclusionsThese data demonstrate that CSF immunoglobulin κ:λ ratios, determined at the time of diagnostic lumbar puncture, predict MS disease progression and may therefore be useful prognostic markers for early therapeutic stratification.
Molecular test for chlamydia and gonorrhoea used at point of care in remote primary healthcare settings: a diagnostic test evaluation
Authors: Causer Louise M , Guy Rebecca J , Tabrizi Sepehr N , Whiley David M , Speers David John , Ward James , Tangey Annie , Badman Steven G , Hengel Belinda , Natoli Lisa Jane , Anderson David A , Wand Handan , Wilson David , Regan David G , Shephard Mark , Donovan Basil , Fairley Christopher K , Kaldor John M 
Published: May 2018

ObjectivesA new molecular test for Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (NG) (GeneXpert CT/NG) has been demonstrated to be as accurate as conventional nucleic acid amplification tests (NAAT), but performance has not been evaluated in routine primary care, performed at the point of care by clinicians. We aimed to examine its diagnostic performance when used by clinicians in remote community health services in Australia with high prevalences of CT and NG infection. The trial was registered with the Australian and New Zealand Clinical Trials Registry (#12613000808741)MethodsAt 12 health services, training was provided to 99 clinicians in the use of the GeneXpert CT/NG assay who tested specimens from all patients undergoing STI screening. Specimens were also sent in parallel for conventional laboratory-based NAATs and the concordance of results was evaluated.ResultsClinicians conducted 2486 tests: CT concordance was 99.4% (95% CI 99.1 to 99.7) with a positive concordance of 98.6% (95% CI 95.9 to 99.7) and negative concordance of 99.5% (95% CI 99.1 to 99.8); NG concordance was 99.9% (95% CI 99.7 to 100.0) with a positive concordance of 100.0% (95% CI 97.5 to 100.0) and negative concordance of 99.9% (95% CI 99.7 to 100.0).ConclusionsIn this first study reporting routine point-of-care use of GeneXpert CT/NG by primary care clinicians, we found excellent concordance with conventional NAATs. The use of the GeneXpert CT/NG at the point of care could potentially transform management and control of these infections in many endemic settings, including low/middle-income countries.
Respiratory mortality of childhood, adolescent and young adult cancer survivors
Authors: Fidler Miranda M , Reulen Raoul C , Bright Chloe J , Henson Katherine E , Kelly Julie S , Jenney Meriel , Ng Antony , Whelan Jeremy , Winter David L , Frobisher Clare , Hawkins Michael M 
Published: May 2018

BackgroundExposure to radiation and/or chemotherapy during cancer treatment can compromise respiratory function. We investigated the risk of long-term respiratory mortality among 5-year cancer survivors diagnosed before age 40 years using the British Childhood Cancer Survivor Study (BCCSS) and Teenage and Young Adult Cancer Survivor Study (TYACSS).MethodsThe BCCSS comprises 34 489 cancer survivors diagnosed before 15 years from 1940 to 2006 in Great Britain. The TYACSS includes 200 945 cancer survivors diagnosed between 15 years and 39 years from 1971 to 2006 in England and Wales. Standardised mortality ratios and absolute excess risks were used.FindingsOverall, 164 and 1079 respiratory deaths were observed in the BCCSS and TYACSS cohorts respectively, which was 6.8 (95% CI 5.8 to 7.9) and 1.7 (95% CI 1.6 to 1.8) times that expected, but the risks varied substantially by type of respiratory death. Greatest excess numbers of deaths were experienced after central nervous system (CNS) tumours in the BCCSS and after lung cancer, leukaemia, head and neck cancer and CNS tumours in the TYACSS. The excess number of respiratory deaths increased with increasing attained age, with seven (95% CI 2.4 to 11.3) excess deaths observed among those aged 50+ years in the BCCSS and three (95% CI 1.4 to 4.2) excess deaths observed among those aged 60+ years in the TYACSS. It was reassuring to see a decline in the excess number of respiratory deaths among those diagnosed more recently in both cohorts.ConclusionsPrior to this study, there was almost nothing known about the risks of respiratory death after cancer diagnosed in young adulthood, and this study addresses this gap. These new findings will be useful for both survivors and those involved in their clinical management and follow-up.
American coastal defence Third System forts: how geomorphology and geology dictated placement and influenced history
Authors: Henderson Stephen W. 
Published: May 2018

Abstract
In total, 42 Third System forts were built along the east coast of the USA between 1816 and 1867. Because of their purpose, to defend key locations against potential British amphibious assault, their sites were limited to islands, shoals, shorelines, riverbanks or hilltops. Sited along the Atlantic and Gulf of Mexico coastlines, many are constructed upon distinctive geomorphological landforms that are related more to features influenced by Quaternary glaciation or sea-level changes than by pre-Quaternary bedrock. A selection of forts is described to illustrate the principal geological and geomorphological features that influenced their construction: at Boston Harbor in Massachusetts on drumlins, near New York City on moraine and at Fort Pulaski protecting Savannah Harbor in Georgia on saltmarsh. Further south, Fort Clinch in northern Florida, forts guarding Pensacola Bay in western Florida and the entrance to Mobile Bay in the Gulf region, and Fort Massachusetts on Ship Island, Mississippi, were all primarily situated on Holocene barrier islands. Construction, use and 1861–65 Civil War threats to these forts can be directly related to their geomorphological context. Although all are now redundant, most remain as a remarkable and highly visible aspect of the military history of the USA.