bluuebunny/crossref_metadata_2025_split huggingface dataset:
Rendimiento en el área de educación física y tipo de huella plantar en escolares limeños
Authors: Peralta-Gonzales Sadith , Santisteban-Francia Jannet , Peralta-Alvarez Frank 
Published: August 2019

Objetivo: determinar si existe asociación entre el rendimiento en el área de educación física y el tipo de huella plantar en escolares limeños. Materiales y métodos: el estudio fue transversal. La muestra fue de 217 escolares de 6 a 12 años. Las variables de estudio fueron: rendimiento académico en el área de educación física, tipo de huella plantar e índice de Hernández Corvo y dos variables sociodemográficas (sexo y edad). Se emplearon las pruebas de Chi-cuadrado, Kruskal Wallis, Spearman y regresión lineal múltiple. Resultados: la media del rendimiento académico fue 15.69 y del índice de Hernández Corvo fue 0.52 en ambos pies. Tanto en el pie derecho (54.38%) e izquierdo (58.99%) se encontró mayor porcentaje en el tipo de huella plantar cavo. No hubo relación entre rendimiento académico y tipo de huella plantar (p=0.26) y el ser mujer se asoció significativamente con tener pie cavo (derecho= 65.52%; izquierdo= 75.86%). En el análisis múltiple al ajustar rendimiento académico, índice de Hernández Corvo y edad hubo significancia. Conclusión: se evidencia que no existe relación entre el rendimiento académico en el área de educación física y el tipo de huella plantar. Por otro lado, ser mujer se relaciona con tener pie cavo. Asimismo, se muestra una tendencia en el aumento del rendimiento académico a través del análisis de regresión lineal. Debido a la poca variabilidad de promedios de rendimiento académico se recomienda emplear un instrumento preciso para medir las notas con indicadores de desempeño práctico y otros instrumentos precisos para medir la huella plantar.
Palabras clave: Pie; Rendimiento Atlético; Estudiantes (Fuente: DeCS).
Inteligencia emocional y bienestar psicológico en adolescentes limeños
Authors: Solórzano-Gonzales Paula 
Published: August 2019

Objetivo: determinar la relación entre inteligencia emocional y bienestar psicológico en adolescentes de un colegio parroquial mixto de Lima metropolitana. Materiales y métodos: estudio correlacional de corte transversal. Se realizó un censo a 233 adolescentes de 4to y 5to de secundaria en una Institución Educativa Parroquial de Lima Metropolitana. Se usaron como instrumentos el Inventario del cociente emocional BarOn (ICE), la Escala BIEPS-J y una ficha sociodemográfica. Para el análisis de los datos se utilizó el paquete estadístico STATA versión 14. Se empleó la prueba de Shapiro Wilk para determinar normalidad. Para las variables categóricas se usó la prueba de Chi-cuadrado y para numéricas la correlación de Pearson y Spearman. Se consideró una significancia estadística ≤ 0.05 Resultados: No existe relación entre la inteligencia emocional y el bienestar psicológico (p=0.97). Se halló asociación entre la edad y la dimensión interpersonal (p=0.001) y entre la religión y la dimensión intrapersonal (p=0.01). El 50% de participantes evidenció un nivel bajo de bienestar psicológico. Conclusión: De manera integral se observa que ambas asociaciones son considerados factores potenciales en el desarrollo de la inteligencia emocional, como adquirir habilidades sociales favorables, afianzar su autonomía, contar con herramientas necesarias para resolver conflictos y tomar decisiones.
Impacto de los sistemas de salud y educación en la vivencia de una madre con un niño con síndrome de Down
Authors: Enríquez-Canto Yordanis 
Published: August 2019

Los niños con síndrome de Down presentan diversos problemas de salud, del comportamiento y del aprendizaje que requieren atención especial. Debido a ello tienen dificultades de recibir atención adecuada. De consecuencia formas de ineficiencia del sistema sanitario y educativo impactan a nivel personal y familiar. Sin embargo, en Perú existe un vacío de información de naturaleza empírica y cualitativa sobre este efecto en la vida de estos niños y sus padres. Empleando un análisis cualitativo de los contenidos de una entrevista a una madre se identificaron siete temas vinculados al impacto de estos dos sistemas: orientación y apoyo, ámbito laboral y condición de salud, relación con el sistema de salud, relación con la escuela, discriminación hacia las personas con discapacidad, cambio de perspectiva respecto a la discapacidad y comunicación no convencional. Los resultados evidencian que las formas de ineficiencia de los sistemas sanitario y educativo impactan negativamente en la vida de las personas con discapacidad y en sus familias. Este impacto afecta la vida familiar y laboral determinado las decisiones educativas y de salud. Igualmente, persisten todavía formas de no aceptación y modalidades de discriminación más o menos evidentes, no obstante los esfuerzos por la inclusión. Las actitudes negativas hacia la discapacidad pueden ser condicionadas por su severidad. De hecho, la aceptación de la discapacidad es un proceso en el que se modifica la percepción. En el mismo, es fundamental enfocarse en la persona y no simplemente en los límites de su condición.
Conocimientos y actitudes de madres con hijos menores de 5 años sobre vacunas
Authors: Arellán-Regalado María 
Published: August 2019

Objetivo: determinar la relación entre el nivel de conocimiento y las actitudes de las madres sobre las vacunas de sus hijos menores de cinco años. Materiales y métodos: el estudio fue descriptivo y correlacional de diseño transversal. La muestra fue de 100 madres que tengan hijos menores de cinco años. En el análisis descriptivo de las variables categóricas se emplearon frecuencias y porcentajes. Para el análisis inferencial se empleó la prueba de Chi-cuadrado. Resultados: el 58% de las madres tuvo un conocimiento medio sobre las vacunas y el 51% demostró una actitud desfavorable sobre las vacunas. Las encuestadas que presentaron una actitud desfavorable tenían un nivel de conocimiento medio sobre las vacunas (66%). Aquellas que solo estudiaban (66%), con ingresos mayores a 1000 soles (80%) y con primaria (100%) presentaron un conocimiento medio sobre vacunas. Por otro lado, las madres con más de dos hijos (66%), las empleadas informales (100%), con ingresos mayores a 1000 soles (80%) manifestaron una actitud desfavorable sobre las vacunas. Conclusión: las madres con un conocimiento medio presentaron una actitud desfavorable sobre las vacunas. Aquellas que solo estudian, con ingresos mayores y con primaria presentan un conocimiento medio sobre vacunas. Por otro lado, las que cuentan con un empleo, más de dos hijos e ingresos mayores manifestaron una actitud desfavorable sobre las vacunas. A partir de estos hallazgos el personal de enfermería pudiera brindar información relevante durante sus intervenciones educativas sobre inmunización a las madres.
Resiliencia y sentido de vida en madres de alumnos de educación especial
Authors: Yvana-Yupanqui Estela 
Published: August 2019

Objetivo: determinar la relación entre la resiliencia y el sentido de vida en madres de alumnos de un centro educativo básico especial. Materiales y métodos: estudio de alcance correlacional y diseño de corte transversal. La muestra estuvo conformada por 120 madres de familia de un colegio de educación especial de Los Olivos. Las variables principales fueron resiliencia y sentido de vida. Se utilizó el programa STATA 14 para el análisis de datos descriptivo e inferencial. Resultados: el 54.17 % de madres presentó resiliencia moderada y un 82.5 % indicadores altos de presencia de sentido de vida. Asimismo, se encontró que existe relación entre el sentido de vida y la resiliencia (p=0.004), de igual forma, entre el sentido de vida con el nivel de instrucción (p=0.015) y la ocupación (p=0.026), respectivamente. Conclusión: el sentido de vida se relaciona con la resiliencia, ya que las situaciones difíciles orientan a las madres a replantear y cuestionar la finalidad de su realidad, ampliando la percepción del sentido de vida. Además les brinda la capacidad de poder adaptarse y hacer frente a situaciones difíciles, llegando a transformar inclusive momentos estresantes. Igualmente encontrar un sentido de vida, a pesar de las adversidades, se identificó en las madres que se dedican a las labores de la casa y que alcanzaron estudios superiores o culminó la secundaria.
CRYOPRECIPITATE PRODUCTION IN RUSSIA: PAST, PRESENT AND FUTURE
Authors: Zhiburt E. B. , Chemodanov I. G. , Shestakov E. A. 
Published: August 2019

Aim. To determine the dynamics of cryoprecipitate production in Russian blood service institutions in comparison with such institutions in other countries.Materials and methods. Reports provided by Russian blood service institutions during the 1997–2017 period were analysed, along with European standards for blood collection and transfusion.Results. Over the 1997–2004 period, the number of cryoprecipitate units issued annually ranged from 263,897 (2000) to 297,890 (2002) units. Over the subsequent 8 years, the number of annually released cryoprecipitate decreased to 23,663 units, having reached a historical minimum in 2012. From 2012 to 2017, the number of annually issued cryoprecipitate units increased by 80.0 %, reaching the amount of 42,589 units. Reasons for such a wavelike dynamics in cryoprecipitate production in Russia have been determined. In addition, directions for expanding the use of this product in the correction of hypofibrinogenemia have been identified.Conclusion. Cryoprecipitate should be re-introduced into the practice of clinical transfusiology. To this end, national clinical guidelines for cryoprecipitate application should be developed.
EFFICACY OF OLIGONUCLEOTIDE DSP30 IN COMBINATION WITH INTERLEUKIN-2 FOR THE DETECTION OF CHROMOSOMAL ABERRATIONS IN PATIENTS WITH CHRONIC LYMPHOCYTIC LEUKEMIA
Authors: Kislitsyna M. A. , Obukhova T. N. , Alimova G. A. , Shishigina L. A. , Grebenyuk L. A. , Abramova T. V. , Goryacheva S. R. , Moiseeva T. N. 
Published: August 2019

Aim.To evaluate the efficacy of DSP30 in combination with IL2 in cultivating blood cells/bone marrow/lymph nodes in chronic lymphocytic leukemia (CLL) patients to detect clonal abnormalities.Materials and methods.The study included 50 patients with CLL, all of whom underwent both chromosome banding analysis (CBA) (46 patients with DSP30+IL2 and LPS+TPA; 4 patients with only DSP30+IL2) and FISH with DNA probes to detect trisomy 12 and deletions of 13q14, 11q22 and 17p13.Results.Under cell cultivation with DSP30+IL2 and LPS+TPA, CBA was successfully performed in 41 (82 %) and 38 (83 %) patients. Chromosome aberrations were observed in 36 (72 %) and 15 (33%) cases, while a complex karyotype was detected in 13 (26%) and 5 (11%) cases, respectively. A significant difference was found between the number of metaphases with chromosomal abnormalities obtained by cultivation with DSP30+IL2 and LPS+TPA (V = 490.5, p < 0.05). CBA revealed balanced translocations in 6 patients, with the involvement of the IgH/14q324 locus being confirmed in 4 cases. Unbalanced translocations and various combinations of translocations were detected in 11 and 6 patients, respectively. In 5 cases, according to CBA, the results of 13q14, 11q22, 17p13 deletions identified by FISH were accompanied by balanced or unbalanced translocations in these loci. Unbalanced t(12;16)(q14;q23) — a case of partial trisomy — was detected only by CBA with DSP30+IL2.Conclusions.An abnormal karyotype was detected in CLL patients twice as more frequently under cultivation with DSP30+IL2 compared to LPS+TPA. CBA is an important method allowing the structure of chromosomal abnormalities to be specified and translocations to be identified. As a result, patients running the highest risk of CLL — those with a complex karyotype — can be singled out for selecting an optimal strategy of their management.
SECOND ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION IN PATIENTS WITH HEMATOLOGICAL MALIGNANCIES
Authors: Kuzmina L. A. , Konova Z. V. , Parovichnikova E. N. , Drokov M. Y. , Vasilyeva V. A. , Popova N. N. , Savchenko V. G. 
Published: August 2019

Background.Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a standard treatment for many patients with hematological malignancies. Complications of allo-HSCT are frequently associated either with a relapse of the underlying disease or a graft failure. Second transplantation can be offered to selected patients and is seen as the only curative option. In this paper, we report the experience of managing 24 such patients, all of whom underwent a second allo-HSCT.Patients and methods.The research involved 24 patients (12 males/12 females) suffering from acute myeloid leukemia (AML, n = 14), acute lymphoblastic leukemia (ALL, n = 4), myeloproliferative disease (MPD, n = 3) and myelodysplastic syndrome (MDS, n = 3). The patients’ age ranged from 18 to 56 years, with the median age being 32 years. All the patients underwent a second allo-HSCT due to the disease relapse (n = 11) or graft failure (n = 13). 12 patients underwent a second allo-HSCT within the period of less than 6 months after the first allo-HSCT.Results.Following the second allo-HSCT, engraftment occurred in 18/24 (75 %) patients, while 3 patients demonstrated graft failure and 3 — disease progression. Out of 18 patients having engrafted, 9 (50%) died during the first 100 days after allo-HSCT as a result of severe infections or visceral toxicity. 3 more lethal outcomes were recorded in later periods due to the disease progression. The overall mortality rate after the second allo-HSCT equalled 61.5 %. The median overall survival (OS) and disease-free survival (DFS) rates were 13.5 months and 10.59 months, respectively. Three-year OS and DFS were 38.5 % and 27.6 % respectively. Significant differences in terms of OS were detected for patients with a longer interval (>6 months) between the first and second allo-HSCT. The change of a donor was not associated with a better clinical outcome.
PREVALENCE OF FACTOR V LEIDEN AND PROTHROMBIN G20210A IN WOMEN WITH VON WILLEBRAND DISEASE TYPE 1
Authors: Koloskov A. V. , Chernova E. V. 
Published: August 2019

Background.Von Willebrand disease is a hereditary malfunction of the blood coagulation system caused by waveform quantitative and/or qualitative deficiency of von Willebrand factor (vWF).Aim.To evaluate the frequency of occurrence of FVLeiden and FII G20210A mutations in female patients with von Willebrand type 1 disease.Materials and methods.136 women aged from 18 to 45 years (mean 31.7 ± 0.5 years) were enrolled in a study conducted during the January 2011 — December 2017 period. Questionnaire was used to reveal hemorrhagic diathesis. Inclusion criteria were as follows: no less than 3 positive responses to questions 1–7, or 2 positive responses to questions 1–7 plus no less than 100 points of the evaluated menstrual blood loss. An independent inclusion criterion was 180 points or more in the question concerning menstrual blood loss. A mandatory inclusion criterion was the confirmation of absence of thromboembolic events in a proband and first line relatives. The study included assessment of such parameters as ristocetin-cofactor activity of von Willebrand factor (vWF:RCo), von Willebrand factor antigen (vWF:Ag), factor VIII (FVIII:C), platelet aggregation induced with ADP, ristomycin, collagen, as well as molecular-genetic assay of factor V (FVLeiden) and gene (FII G20210A) polymorphism using allele-specific polymerase chain reaction.Results.No mutations of FVLeiden and FII G20210A were revealed in 102 women with von Willebrand disease type 1. Heterozygous mutation of FVLeiden was found in 12 (8.8 %) subjects with von Willebrand disease type 1 (vWF:RCo from 27 to 47 % (mean 37.3 ± 0.8 %), vWF:Ag from 25 to 46 % (mean 37.5 ± 0.8 %), FVIII:C from 29 to 49 % (mean 44.1 ± 0.5 %). Homozygous mutation of FVLeiden was identified in 3 (2.2%) women with von Willebrand disease type 1, with vWF:RCo being 40, 43 and 45 %, vWF:Ag — 39, 44 and 42 %, FVIII:C — 47, 45 and 48 %, respectively. Heterozygous mutation FII G20210A was detected in 19 (13.9 %) subjects with von Willebrand disease type 1 (vWF:RCo from 36 to 49 % (mean 43.0 ± 0.4 %), vWF:Ag from 32 to 46 % (mean 42.2 ± 0.6 %), FVIII:C from 30 to 49 % (mean 45.1 ± 0.4 %).Conclusion.By means of diminishing the coagulation potential of the blood coagulation system, a decrease in the activity of VIII and von Willebrand factors may compensate possible negative effects associated with FVLeiden and FII G20210A gene mutations in female patients with von Willebrand type 1 disease.
MOLECULAR FEATURES OF BORTEZOMIB-INDUCED NEUROPATHY IN PATIENTS WITH MULTIPLE MYELOMA
Authors: Nazarova E. L. , Minaeva N. V. , Zotina E. N. , Dokshina I. A. , Suhorukova E. E. , Shardakov V. I. 
Published: August 2019

Background. The regimens of therapy with bortezomib have significantly improved the survival among patients with multiple myeloma (MM). However, the development of peripheral polyneuropathy (PP) resulting from treatment using proteasome inhibitors is still an undesirable event. Risk factors for PP in MM patients include old age, previous neuropathy and use of neurotoxic drugs. Recent studies have established the presence of a genetic component in the mechanism of developing bortezomib-induced neurotoxicity. However, there are conflicting opinions on the role of genetic characteristics in predicting the risk of treatment-induced neuropathy development.Aim. To identify the risk group of bortezomib-induced PP based on the analysis of gene polymorphism of the immune response in patients with newly-diagnosed MM.Materials and methods. A study of the association of 20 polymorphic loci of 14 immune response genes in 46 MM patients was conducted using a candidate gene identification approach. All the patietns were receiving VCD therapy with bortezomib.Results. The distribution of single nucleotide polymorphisms was compared in groups of patients with the presence and absence of PP. It is found that homozygous carriers of the wild type allele of the genes TLR6 (Ser249Pro) (p = 0.006), IL1β (G-1473C) (p = 0.04), IL4 (C-589T) (p = 0.04), as well as haplotype carriers with the mutant allele of the gene IL10 (G-1082A) (p = 0.04) and with the wild type allele gene IL2 (T-330G) (p = 0.01) were significantly more frequent among PP patients.Сonclusion. Our results have confirmed the contribution of the genetic component to the risk of developing bortezomibinduced neuropathy. These findings can be used for individualization of therapeutic approaches to the treatment of MM patients.
Growth study of coi fish larvae fed chydoridae
Authors: Pangkey Henneke , Lantu Sartje , Monijung Revol D. 
Published: August 2019

First culture media for chydoridae used horse manure dried in the sun with a composition of 10 grams and 50 grams of soil dissolved in 1 L of water for 5 days, then filtered and diluted three times. Laboratory-scale cultures were carried out in a 500 ml volume jar containing horse manure culture media; then in the process fed with bread yeast and rice bran (0.05 gr yeast and rice bran/500 ml) every 3 days. Mass culture uses 12 jar containers with a volume of 3 L.The administration of chydoridae to two-day old koi fish larvae was carried out with the following treatments: treatment A, which was ornamental fish fed with boiled egg yolk in ad libitum; treatment B is ornamental fish fed with 5 individual chydoridae/ml and treatment C, which is not given any food with three replications. The design of the response in this study was to see the survival rate of ornamental fish larvae (%).The results of measurements of water quality during the study showed that the temperature during the study was 27°C, while the pH was 7. From the statistical analysis it was found that administration of chydoridae had a significant effect on the survival of two-day-old koi fish larvae which were kept for 14 days.Keywords: chydoridae, life feed, ornamental fish larvae, growthABSTRAKMedia kultur awal chydoridae menggunakan kotoran kuda yang dikeringkan di bawah sinar matahari dengan komposisi 10 gram kotoran kuda serta 50 gram tanah yang dilarutkan dalam 1 L air selama 5 hari, kemudian dilakukan penyaringan dan diencerkan sebanyak tiga kali. Kultur skala laboratorium dilakukan dalam wadah toples dengan volume 500 ml berisi media kultur kotoran kuda; selanjutnya dalam proses kultur chydoridae diberi makan ragi roti dan dedak (0,05 gr ragi dan dedak /500 ml) setiap 3 hari sekali. Kultur massal menggunakan wadah toples sebanyak 12 buah dengan volume 3 L dengan mengikuti metode pada kultur skala laboratorium.Pemberian chydoridae kepada larva ikan koi yang berumur dua hari dilakukan dengan beberapa perlakuan sebagai berikut : perlakuan A yaitu ikan hias diberi makan kuning telur rebus secara ad libitum; perlakuan B yaitu ikan hias diberi makan chydoridae 5 individu/ml dan perlakuan C yaitu ikan hias tidak diberi makan apapun dengan tiga ulangan. Rancangan respons dalam penelitian ini adalah melihat laju kelangsungan hidup larva ikan hias (%).Hasil pengukuran kualitas air selama penelitian menunjukkan, suhu selama penelitian adalah 27 °C, sedangkan pH adalah 7. Dari hasil analisis statistik diperoleh bahwa pemberian chydoridae sangat memberi pengaruh nyata kepada kelangsungan hidup larva ikan koi berumur dua hari yang dipelihara selama 14 hari.Kata kunci: chydoridae, pakan alami, larva ikan hias, pertumbuhan
The investigation of properties dependence of samples from zirconia stabilized by CaO on a phosphate binder on the P2O5 content and the thermal treatment temperature
Authors: Martynenko V. V. , Primachenko V. V. , Shulik I. G. , Galchenko T. G. , Tishina T. G. , Varganov V. V. 
Published: August 2019

The dependence of main properties of samples from zirconia stabilized by CaO, on a phosphate binder from orthophosphoric acid on the P2O5 content (0.8, 1.4, 2.0, 2.6 %) and their thermal treatment temperature (200, 400, 1000, 1200, 1400, 1580, 1750, 2000 ОC) has been investigated. The optimal amount of the phosphate binder (2.0 % in P2O5) was established, providing some increase in the strength of refractories made of zirconia stabilized by CaO, at temperatures of ~ 1750—2000 ОC compared with other quantities of P2O5. Using the petrographic and X-ray phase methods, the dependence of phase composition and structure of samples from zirconia stabilized by CaO, on the phosphate binder on the thermal treatment temperature and P2O5 content was investigated.
As a result of the carried out studies, the production technology of ramming mass from CaO-stabilized zirconia and products from it on the binder made of orthophosphoric acid, designed for service temperatures up to 2350 ОC, has been improved. Products manufactured according to the improved technology will increase their durability in the service and increase the operation duration of high-temperature industrial units.