bluuebunny/crossref_metadata_2025_split huggingface dataset:
Surface integrity in wire-EDM tangential turning of in situ hybrid metal matrix composite A359/B4C/Al2O3
Authors: Srivastava Ashish Kumar , Nag Akash , Dixit Amit Rai , Hloch Sergej , Tiwari Sandeep , Scucka Jiri , Pachauri Praveen 
Published: August 2018

Abstract
In this work, wire electric discharge turning, a novel and unconventional technique, was used for the turning operation of a newly developed hybrid metal matrix composite of aluminum (A359/B4C/Al2O3) fabricated in-house by electromagnetic stir casting. The objective of the work was to examine the effect of rotational speed on the elements of surface integrity. It involved the measurement of various parameters such as the roughness (Ra, Rq, Rz), morphology of the recast layers, microhardness variation, and the formation of residual stresses on the machined surface and in the subsurface during the operation. The quality of the turned surface was examined by 3D surface visualization images and surface topographical details obtained by an Olympus LEXT OLS 3100 laser confocal microscope. Further, surface study at the microscopic level was done by field-effect scanning electron microscopy (FE-SEM) images to examine the surface defects. The measurement results revealed a successful turning operation, which showed a dull, textured surface without any specific texture or pattern on the machined surface. The surface had many peaks and valleys with small-scale of defects such as surface porosity. However, these defects were negligible and resulted in a smooth surface finish at high rotational speeds.
Facile one-pot syntheses of new C-28 esters of oleanolic acid and studies on their antiproliferative effect on T cells
Authors: Ali Muhammad S. , Ahmed Ghafoor , Mesaik Muhammad A. , Shah Muhammad R. , Lateef Mehreen , Ali Muhammad I. 
Published: August 2018

AbstractStructure-activity relationship studies on oleanolic acid (1) have resulted in facile syntheses of its new C-28 esters2–7by way of one-pot reaction of1with a variety of alkylating agents. Oleanolic acid and its new esters were studied for their in vitro antiproliferative effect on healthy human peripheral blood mononuclear cell isolated phytohemagglutinin activated T cells. Results showed that compounds1,3, and5exhibited significant inhibitory activity on T-cell proliferation. Compound5was found to be the most potent, with an IC50value of 4.249 μg/mL, among all tested compounds, and its activity could be attributed to the presence of bromine atom in the molecule.
Enhancing the Evaluation and Interpretation of Fitness Testing Data Within Youth Athletes
Authors: Till Kevin , Morris Rhys , Emmonds Stacey , Jones Ben , Cobley Stephen 
Published: August 2018

ABSTRACT
FITNESS TESTING IS COMMON PRACTICE WITHIN YOUTH ATHLETES. HOWEVER, THE INTERPRETATION OF FITNESS DATA OFTEN OCCURS WITHIN CHRONOLOGICAL ANNUAL-AGE CATEGORIES, RESULTING IN ATHLETES BEING (DIS)ADVANTAGED DUE TO AGE OR MATURITY DISCREPANCIES. INSTEAD, EVALUATING FITNESS PERFORMANCE AGAINST ROLLING AVERAGES MAY BE MORE APPROPRIATE. THIS ARTICLE PRESENTS A NOVEL METHOD FOR ANALYZING FITNESS TESTING DATA IN YOUTH ATHLETES USING Z-SCORES ACCORDING TO ROLLING AVERAGES FOR BOTH CHRONOLOGICAL AGE AND MATURITY STATUS. THIS ANALYSIS TECHNIQUE ALLOWS FOR THE DUAL ABILITY TO INTERPRET YOUTH FITNESS PERFORMANCE ACCORDING TO AGE AND MATURATION, ENHANCING ACCURACY OF DATA INTERPRETATION FOR TALENT IDENTIFICATION, DEVELOPMENT, AND STRENGTH AND CONDITIONING PROGRAMMING.
Efficacy and safety of switching to pasireotide in acromegaly patients controlled with pegvisomant and somatostatin analogues: PAPE extension study
Authors: Muhammad Ammar , Coopmans Eva C , Delhanty Patric J D , Dallenga Alof H G , Haitsma Iain K , Janssen Joseph A M J L , van der Lely Aart J , Neggers Sebastian J C M M 
Published: August 2018

ObjectiveTo assess the efficacy and safety after 48 weeks of treatment with pasireotide long-acting-release (PAS-LAR) alone or in combination with pegvisomant in patients with acromegaly. In addition, we assessed the relation between insulin secretion and pasireotide-induced hyperglycemia.DesignThe PAPE extension study is a prospective follow-up study until 48 weeks after the core study of 24 weeks.MethodsFifty-nine out of 61 patients entered the extension study. Efficacy was defined as the percentage of patients achieving IGF-I normalization (≤1.2× the upper limit of normal (ULN)) at 48 weeks through protocol-based adjustment of pegvisomant and PAS-LAR doses. At baseline, insulin secretion was assessed by an oral glucose tolerance test (OGTT).ResultsAt the end of the study, median IGF-I was 0.98× ULN, and 77% of patients achieved normal IGF-I levels with a mean pegvisomant dose of 64 mg/week, and an overall cumulative pegvisomant dose reduction of 52%. Frequency of diabetes mellitus increased from 68% at 24 weeks to 77% at 48 weeks, and nine patients discontinued PAS-LAR treatment, mainly because of severe hyperglycemia. Pasireotide-induced hyperglycemia was inversely correlated with baseline insulin secretion (r = −0.37,P < 0.005).ConclusionsPAS-LAR normalizes IGF-I levels in most acromegaly patients, with a 50% pegvisomant-sparing effect. However, PAS-LAR treatment coincided with a high incidence of diabetes mellitus. The risk for developing diabetes during PAS-LAR treatment seems inversely related to insulin secretion at baseline.
ТЕОРЕТИЧНИЙ ЗМІСТ ЛЮДСЬКОГО КАПІТАЛУ ТА ЙОГО СКЛАДОВІ
Authors: Bondarchuk N.V. 
Published: August 2018

Стаття присвячена дослідженню теоретичного змісту людського капталу та визначення його основних складових. Метою дослідження є визначення теоретичного змісту поняття «людський капітал» як об’єкта обліку та його складових. Встановлено, що центральне місце в процесі переходу економіки на інноваційний шлях розвитку, яка повинна мати високий творчий потенціал, бути висококваліфікованим професіоналом. Від професіоналізму працівника залежать результати інтелектуальної, інноваційної діяльності та успіхи в інноваційній економіці.
Наведено основні визначення поняття “людський капітал” у працях економістів. Констатовано, що людина та її продуктивні здібності займають центральне місце в психолого-педагогічних та соціально-економічних науках. Відмінності у трактуванні даної дефініції залежать: по-перше, у виокремленні складових людського капіталу (капітал здоров’я, інтелектуальний капітал, мобільність, мотивація, культура, творчі здібності, талант, виховання, менталітет, адаптивність); – по-друге, у сфері використання людського капіталу (економічна, соціальна, психологічна, педагогічна, управлінська, облікова категорія).
Для формування повного уявлення про сутність, особливості людського капіталу та його значимість у різних сферах діяльності суб’єктів господарювання змістовно розкрито елементи досліджуваної категорії. Визначено основні складові людського капіталу серед яких: капітал здоров’я, інтелектуальний капітал, мобільність, мотивація, культура, творчі здібності, талант, виховання, менталітет, адаптивність). В процесі дослідження уточнено функції кожної із складової людського капіталу.
Основними напрямами подальших досліджень є конкретизація облікових принципів і процедур людського капталу, формування єдиних методичних підходів у способах оцінювання людського капіталу.
ПРОБЛЕМИ І ОСОБЛИВОСТІ РОЗВИТКУ МАЛОГО ТА СЕРЕДНЬОГО ПІДПРИЄМНИЦТВА В ІВАНО-ФРАНКІВСЬКІЙ ОБЛАСТІ
Authors: Rishchuk L.I. 
Published: August 2018

Охарактеризовано особливості та проблеми розвитку підприємництва в регіоні, адже за останні роки спостерігається тенденція до зменшення кількості підприємств в області. Охарактеризовано регіональну цільову програму розвитку підприємництва, реалізація якої сприятиме створенню нових та розвитку існуючих об’єктів інформаційної та інфраструктурної мережі підтримки підприємництва, збільшенню фінансово-кредитної підтримки, залученню суб’єктів підприємницької діяльності до участі у проектах міжнародної технічної допомоги. Обґрунтовано пропозиції ефективного розвитку малого та середнього підприємництва на регіональному рівні.
ЗАБЕЗПЕЧЕННЯ ФУНКЦІОНУВАННЯ ТА РОЗВИТКУ ТЕРИТОРІАЛЬНИХ ГРОМАД
Authors: Yevdokimov O.V. 
Published: August 2018

Метою публікації є визначення механізму планування забезпечення потреб об’єднаної територіальної громади. В якості методів дослідження виступили теоретичний аналіз та узагальнення вітчизняного та закордонного досвіду функціонування муніципальних утворень. За результатами дослідження запропонований механізм планування забезпечення потреб об’єднаної територіальної громади, що дозволяє максимізувати ефективність її соціально-економічного розвитку за мінімальних фінансових вливань. Наукова новизна даної публікації полягає у розширенні інструментарію планування поточних видатків місцевого самоврядування, пов’язаних з забезпеченням функціонування громади. Практичне застосування її результатів потенційно здатне підвищити ефективність процесу задоволення потреб жителів територіального утворення.
ПІДХОДИ ДО КЛАСИФІКАЦІЇ ІНФРАСТРУКТУРИ СИСТЕМ ЕЛЕКТРОННОЇ КОМЕРЦІЇ
Authors: Baran R.Yа. 
Published: August 2018

Стаття спрямована на дослідження складових систем забезпечення електронної комерції та їх систематизацію. Метою даної статті є дослідження особливостей основних засобів та інструментів підтримки систем електронної комерції, а також вдосконалення існуючих класифікацій її інфраструктури. Проаналізовано існуючі підходи до класифікації елементів інфраструктури систем електронної комерції, що дозволило визначити їх основні переваги та недоліки. Запропоновано підхід, який передбачає розгляд інфраструктури систем електронної комерції на семи рівнях: ІТ-інфраструктура, телекомунікаційна, організаційно-правова, фінансова, логістична, маркетингова та кадрова інфраструктура.
NGR-hTNF and Doxorubicin as Second-Line Treatment of Patients with Small Cell Lung Cancer
Authors: Gregorc Vanesa , Cavina Raffaele , Novello Sivia , Grossi Francesco , Lazzari Chiara , Capelletto Enrica , Genova Carlo , Salini Giulia , Lambiase Antonio , Santoro Armando 
Published: August 2018

Abstract

Lessons Learned
NGR-hTNF was safely combined with doxorubicin, showing a promising antitumor activity in unselected patients with relapsed small cell lung cancer. Similar antitumor activity was observed in platinum-sensitive and platinum-resistant patient cohorts.

Background
Relapsed small cell lung cancer (SCLC) patients have limited treatment options and poor outcomes. NGR-hTNF is a vascular-targeting agent, which increases intratumoral chemotherapy penetration and T-lymphocyte infiltration.

Methods
Twenty-eight patients relapsing after at least one platinum-based regimen with a treatment-free interval shorter (n = 16; platinum-resistant) or longer (n = 12; platinum-sensitive) than 3 months received NGR-hTNF 0.8 μg/m2 plus doxorubicin 75 mg/m2 every 3 weeks. The primary endpoint of this single-arm phase II trial was progression-free survival (PFS), and safety, response rate, and survival were secondary endpoints.

Results
The most common grade 3–4 toxicities were neutropenia (53%) and anemia (21%). Median PFS was 3.2 months for all patients, 2.7 months for platinum-resistant patients, and 4.1 months for platinum-sensitive patients. Seven patients had partial responses (25%), including four (25%) with platinum-resistant and three (25%) with platinum-sensitive relapse. Mean changes from baseline in tumor burden (after two, four, and six cycles) did not differ between platinum-resistant (−9%, −29%, and −32%) and platinum-sensitive (−11%, −20%, and −43%) cohorts. Overall survival was associated only with baseline lymphocyte counts, with median survival times of 13.1 and 5.2 months for lymphocyte counts above or below the median, respectively.

Conclusion
NGR-hTNF plus doxorubicin showed manageable toxicity and promising activity in patients with relapsed SCLC.
PENERAPAN DICTATION TEST DALAM PERKULIAHAN CHOKAI
Authors: Wardhana Chevy Kusumah 
Published: August 2018

Penelitian ini bertujuan untuk mencari solusi kongkret dalam mengatasi permasalahan rendahnya kemampuan menyimak mahasiswa semester enam Prodi Pendidikan Bahasa Jepang UNNES dengan menerapkan Dictation Test dalam perkuliahan Chokai Enshu. Dictation test menjadi alternatif solusi dari permasalahan kurangnya kebiasaan menulis catatan ketika mahasiswa menyimak materi perkuliahan Chokai. Metode yang digunakan yaitu metode penelitian observasi. Berdasarkan hasil umpan balik yang dilakukan penulis, terlihat adanya respon positif yang ditunjukkan oleh mahasiswa. Hal tersebut dapat dilihat dari adanya kegiatan menulis catatan ketika materi Chokai sedang diperdengarkan, pemahaman dari mahasiswa mengenai materi yang telah didengarkan semakin meningkat terbukti dengan bisa menjawab latihan soal ketika sesi diskusi. Adanya upaya dan kerja keras untuk membiasakan diri melakukan kegiatan menulis catatan untuk meningkatkan kemampuan menyimak bahasa Jepang, dan adanya antusias mahasiswa karena adanya umpan balik yang positif ketika kegiatan diskusi berlangsung
Pengaruh Suhu Pembakaran terhadap Karakteristik Listrik Keramik Film Tebal Berbasis Fe2O3–MnO–ZnO untuk Termistor NTC
Authors: Sari Puspita , Syarif Dani Gustaman , Wiendartun Wiendartun 
Published: August 2018

Pembuatan keramik film tebal berbasis Fe2O3–MnO–ZnO untuk termistor NTC dari campuran Fe2O3 50% mol, MnO 25% mol, dan ZnO 25% mol telah dilakukan. Campuran serbuk Fe2O3, MnO dan ZnO yang telah digerus dicampurkan dengan organic vehicle (OV) untuk membentuk pasta. Kemudian pasta dilapiskan di atas substrat alumina menggunakan teknik screen printing untuk membentuk film tebal. Film tebal mentah yang diperoleh, dibakar pada suhu yang berbeda yaitu 1000°C, 1100°C, dan 1200°C selama 2 jam. Sebelum dilakukan pengukuran resistansi, film tebal dilapisi perak terlebih dahulu sebagai kontak logam. Resistansi termistor diukur pada suhu 40°C–200 oC dengan beda suhu sebesar 5 oC. Analisis struktur kristal dan struktur mikro film tebal masing – masing dilakukan dengan menggunakan X – Ray Diffraction (XRD) dan Scanning Electron Microscopy (SEM). Hasil analisis karakteristik listrik termistor yang dibakar pada suhu 1000 °C, 1100 °C, dan 1200 °C menghasilkan konstanta termistor berturut – turut sebesar 7700 K, 6995 K, dan 5701 K. Ketiga suhu pembakaran menghasilkan nilai konstanta termistor yang memenuhi kebutuhan pasar. Analisis struktur kristal menggunakan XRD menunjukkan bahwa keramik film tebal memiliki dua struktur yaitu struktur spinel kubik dan hematit heksagonal. Analisis struktur mikro menggunakan SEM menunjukkan bertambahnya ukuran butir sesuai dengan meningkatnya suhu pembakaran dengan ukuran butir film tebal yang dibakar pada suhu 1000 °C, 1100 °C, dan 1200 °C berturut – turut adalah 1.3 μm, 2.0 μm, dan 2.4 μm.
Electronic-Banking Services: A Study on Selected Commercial Banks in Bangladesh
Authors: Hossain Md. Motahar , Irin Dilara , Islam Md. Shajedul , Saha Sumi 
Published: August 2018

E-Banking as the wave of the future, provides enormous benefits to consumers in terms of cost of transactions, either through internet, telephone or other electronic delivery channels. E-Banking is now widely practiced in Bangladesh. There are various types of e-banking services like SMS banking, Tele Banking, Push and Pull services, ATM, Fast Track etc. that have been introduced by the commercial banks in Bangladesh. This study attempts to explore various forms and characteristics of e-banking and finds out the merits and demerits of e-banking in selected commercial banks of our country. The major findings of the study show that all the commercial banks selected for the study have been practicing e-banking successfully and Dutch-Bangla Bank Ltd. is providing electronic banking services more effectively than other commercial banks selected in this study. Besides, there is a positive impact of e-banking on the socio-economic development in Bangladesh. There should be diversification of such activities in rural areas of Bangladesh.
JEL Classification Code: M15
Talent Management: Three new Perceptions intended for managing and retaining Talent in Bangladesh
Authors: Mohaimen Md. Abul 
Published: August 2018

This study aims at investigating the methods, importance, process, and present situation of managing talented employees in Corporations. The study revealed that having talented employees helps organizations to drive and be competitive but it is difficult to acquire such people. Thus, some innovative campaigns, for instance, global trainee and management cycle star programs have been created to motivate talented graduates to join the companies and to motivate existing talented employees to being more dedicated and engaged. In the recruitment of new employees, personality and interpersonal skills were more important than educational background because candidates were deemed to be proficient in specific areas, so, what a candidate must have is a personality matching the company’s culture especially the characteristic of working as a good team member. In this study, we suggested some important steps and methods that can be applied in the organizations which are totally running and managing by the HR Department. Moreover, these methods and steps can become successful by managing low rate of star turnover which is quite sensitive case now a day.
JEL Classification Code: J24
Foreign Direct Investment as an Instrument for promoting Economic Development in Bangladesh
Authors: Rahman Md. Sajedur , Ahsan Md. Ali 
Published: August 2018

A healthy financial sector is very much crucial for economic growth, especially for economies like Bangladesh. Because, growth in Bangladesh must come largely from exports and its enterprises must, therefore, be internationally competitive. But unfortunately, Bangladesh has a financial system in which borrowers fail to repay loans, foreclosure is almost unheard of, and the government has to bail out banks. However, the Foreign Direct Investment (FDI), the most powerful weapon for accelerating economic development in Bangladesh. To attain an economic growth rate in the seven to eight percent range, investment has to be increased significantly, Because of declining levels of official development assistance in recent years and inadequate domestic savings, FDI presents opportunities for overcoming domestic resource constraints. The Board of investment (BOI) was created as market mechanism where investors can cut through red-tape associated with foreign trade and business start-ups. FDI basically helps to fill-up the capital gap and shortage of a country. Foreign Direct Investment is one of the vital forces to boost up the economy. In this study paper I would like to draw a current scenario of Foreign Direct Investment in Bangladesh. In this regard I present the most updated data, avoid the uncompleted data and use the best judgment at the time of presenting the data to better knowing the current trend about the Foreign Direct Investment in Bangladesh. The benefits of FDI in terms of physical capital formation, transfer of technology, and know-how are sufficient to justify sustaining these flows. Capital controls are not the answer to a rising flow of FDI. Foreign Direct Investment (FDI) will help the country in further developing infrastructures, creating more employment, developing capacity, enhancing skills of the labour force of the host country through transferring technological knowledge and managerial capability. To ensure that resulting payments liabilities remain within the country’s debt-servicing capacity, it is essential to develop an effective non-intrusive reporting and monitoring system the main ingredients of which are presented in the study.
JEL Classification Code: G11, O24
May E-Governance Create Digital Divide?
Authors: Romke Rowshon Ara 
Published: August 2018

Developing country (DC) governments have been using information and Communication technologies (ICTs) supporting and transforming the external Workings of governance by processing and communicating data. E-Governance should be seen to encompass all ICTs, but the key innovation is computer networks. Bangladesh has failed to progress towards achieving its target as envisaged in its information Technology (IT) policy documentation. Besides, the unequal access to computers and other digital technologies in the developing world from the developed world creates digital divide. Closing the technology gap would lift people out of poverty, while creating a large business opportunity for the high technology industry (World Resources Institute, 2000). My aim in this paper is to present an outline of E-Governance which create digital divide in Bangladesh. This type of research is rare and it would help the society and the country to understand the problem of digital divide and the progress of E-Governance. The paper concludes some problems designed to stimulate farther thoughts and advanced research.
JEL Classification Code: G39
The Social Network of High and Low Self- Monitors and it’s Impact on Organization’s Performance
Authors: Shaker Fahim 
Published: August 2018

Self-monitoring as a personality attribute is given particular attention by researchers in order to understand employee performance and productivity in the organizational context. Numerous studies focused on the impact of self-monitoring from individual employee perspective with limited focus on the impact of the organization’s performance. However, to what extent employees with high versus low self- monitors contribute to the organization’s performance needs to be theoretically augmented. Therefore, relying on exploratory method of research, the paper tries to address the impact of high and low self-monitors on organization’s performance. In this perspective, how self-monitoring helps employees to structure a social network within organizational setting and eventually contribute to it’s success is discussed in this paper. The paper addresses the literature review of self-monitoring principles with special interest in its contribution towards organizational performance through previous research compilation within the field of sociology and organization psychology.
JEL Classification Code: M 12; M 14
Icariside II Attenuates Chronic Hydrocephalus in an Experimental Subarachnoid Hemorrhage Rat Model
Authors: Dong Ce , Ming Xing , Ye Zhanying , Wang Pengfei , Wang Lin , Li Zheng , Pan Baogen 
Published: August 2018

Purpose To investigate the role of ICA II in subarachnoid hemorrhage (SAH)- related chronic hydrocephalus. Methods A two hemorrhage injection model of SAH was created in Sprague Dawley rats (6-8 weeks). A total of 125 rats were randomly assigned into five groups: Sham group, SAH group, SAH+ ICA II (1 mg/kg) group, SAH + ICA II (5 mg/kg) group, and SAH + ICA II (10 mg/kg) group. TGF-β1, phospho-Smad2/3, connective tissue growth factor (CTGF), and procollagen type I carboxy-terminal propeptide (PICP) were assessed via real-time PCR, Western blotting, and enzyme-linked immunosorbent assay. Lateral ventricular index, Masson staining, and Morris water maze tests were employed to evaluate subarachnoid fibrosis, hydrocephalus, and long term neurological function following SAH. Results ICA II (1, 5, 10 mg/kg) inhibited subarachnoid fibrosis, attenuated ventriculomegaly, and effectively suppressed SAH related chronic hydrocephalus. In addition, parallel reduced expression of members of the TGF-β1/Smad/CTGF signaling pathway were observed. Importantly, ICA II may improve long term neurocognitive deficits after SAH. Conclusion ICA II might suppress fibrosis via inhibition of TGF-β1/Smad/CTGF pathway, prevent the development of SAH related chronic hydrocephalus, and improve long term neurocognitive defects following SAH.