bluuebunny/crossref_metadata_2025_split huggingface dataset:
PGS Scaffolds Promote the In Vivo Survival and Directional Differentiation of Bone Marrow Mesenchymal Stem Cells Restoring the Morphology and Function of Wounded Rat Uterus
Authors: Xiao Bang , Yang Wenjun , Lei Dong , Huang Jinfeng , Yin Yupeng , Zhu Yiqing , You Zhengwei , Wang Fang , Sun Shuhan 
Published: February 2019

AbstractIntrauterine adhesion (IUA) causing infertility and recurrent miscarriage of reproductive female mammals usually results from endometrium injury. Nevertheless, there is no efficient therapeutic method to avoid IUA. Bone marrow derived mesenchymal stem cells (BMSCs) are an important cell source for tissue regeneration. This study designs and explores the ability of BMSC‐loaded elastic poly(glycerol sebacate) (PGS) scaffold to prevent IUA and compares the effect of PGS with poly(lactic‐co‐glycolic acid) (PLGA) and collagen scaffolds in resumption of damaged rat uteruses. The 3D architecture provided by PGS scaffolds favors the attachment and growth of rat BMSCs. In vivo bioluminescence imaging shows that compared with direct BMSC intrauterine injection, PLGA, and collagen scaffolds, the PGS scaffold significantly prolongs the retention time of BMSCs in a wounded rat uterus model. More importantly, BMSCs can directly differentiate into endometrial stromal cells after transplantation of PGS/BMSCs constructs, but not PLGA/BMSCs and collagen/BMSCs. It is found that the level of transforming growth factor β1 (TGF‐β1), basic fibroblast growth factor (bFGF), vascular endothelial growth factor, and insulin‐like growth factors in the injured endometrium adjacent to PGS/BMSCs constructs is higher than those of rats receiving PLGA/BMSCs, collagen/BMSCs, or BMSCs intrauterine transplantation. Besides, transplantation of PGS/BMSCs leads to better morphology recovery of the damaged uterus than PLGA/BMSCs and collagen/BMSCs. The receptive fertility of PGS/BMSCs is 72.2 ± 6.4%, similar to the one of collagen/BMSCs, but significantly higher than 42.3 ± 3.9% in PLGA/BMSCs. Taken together, PGS/BMSCs may be a promising candidate for preventing IUA.
Anatomy of Skyrmionic Textures in Magnetic Multilayers
Authors: Li Wenjing , Bykova Iuliia , Zhang Shilei , Yu Guoqiang , Tomasello Riccardo , Carpentieri Mario , Liu Yizhou , Guang Yao , Gräfe Joachim , Weigand Markus , Burn David M. , van der Laan Gerrit , Hesjedal Thorsten , Yan Zhengren , Feng Jiafeng , Wan Caihua , Wei Jinwu , Wang Xiao , Zhang Xiaomin , Xu Hongjun , Guo Chenyang , Wei Hongxiang , Finocchio Giovanni , Han Xiufeng , Schütz Gisela 
Published: February 2019

AbstractRoom temperature magnetic skyrmions in magnetic multilayers are considered as information carriers for future spintronic applications. Currently, a detailed understanding of the skyrmion stabilization mechanisms is still lacking in these systems. To gain more insight, it is first and foremost essential to determine the full real‐space spin configuration. Here, two advanced X‐ray techniques are applied, based on magnetic circular dichroism, to investigate the spin textures of skyrmions in [Ta/CoFeB/MgO]n multilayers. First, by using ptychography, a high‐resolution diffraction imaging technique, the 2D out‐of‐plane spin profile of skyrmions with a spatial resolution of 10 nm is determined. Second, by performing circular dichroism in resonant elastic X‐ray scattering, it is demonstrated that the chirality of the magnetic structure undergoes a depth‐dependent evolution. This suggests that the skyrmion structure is a complex 3D structure rather than an identical planar texture throughout the layer stack. The analyses of the spin textures confirm the theoretical predictions that the dipole–dipole interactions together with the external magnetic field play an important role in stabilizing sub‐100 nm diameter skyrmions and the hybrid structure of the skyrmion domain wall. This combined X‐ray‐based approach opens the door for in‐depth studies of magnetic skyrmion systems, which allows for precise engineering of optimized skyrmion heterostructures.
Core–Shell Prussian Blue Analogs with Compositional Heterogeneity and Open Cages for Oxygen Evolution Reaction
Authors: Zhang Wuxiang , Song Hao , Cheng Yan , Liu Chao , Wang Chaohai , Khan Muhammad Abdul Nasir , Zhang Hao , Liu Jizi , Yu Chengzhong , Wang Lianjun , Li Jiansheng 
Published: February 2019

AbstractHere, a reduction‐cation exchange (RCE) strategy is proposed for synthesizing Fe–Co based bimetallic Prussian blue analogs (PBAs) with heterogeneous composition distribution and open cage nanocage architecture. Specially, bivalent cobalt is introduced into a potassium ferricyanide solution containing hydrochloric acid and polyvinyl pyrrolidone. The uniform PBAs with opened cages are formed tardily after hydrothermal reaction. Time‐dependent evolution characterization on composition elucidating the RCE mechanism is based on the sequential reduction of ferric iron and cation exchange reaction between divalent iron and cobalt. The PBA structures are confirmed by electron tomography technology, and the heterogeneous element distribution is verified by energy‐dispersive X‐ray spectroscopy elemental analysis, leading to the formation of core–shell PBAs with compositional heterogeneity (Fe rich shell and Co rich core) and open cage architecture. When the PBA catalysts are used to boost the oxygen evolution reaction (OER), superior OER activity and long‐term stability (low overpotential of 271 mV at 10 mA cm−2 and ≈5.3% potential increase for 24 h) are achieved, which is attributed to the unique compositional and structural properties as well as high special surface areas (576.2 m2 g−1). The strategies offer insights for developing PBAs with compositional and structural multiplicity, which encourages more practical catalytic applications.
Desulfurization Efficiency Preserved in a Heterometallic MOF: Synthesis and Thermodynamically Controlled Phase Transition
Authors: Han Yi , Sinnwell Michael A. , Teat Simon J. , Sushko Maria L. , Bowden Mark E. , Miller Quin R. S. , Schaef Herbert T. , Liu Lili , Nie Zimin , Liu Jun , Thallapally Praveen K. 
Published: February 2019

AbstractEfficient removal of heterocyclic organosulfur compounds from fuels can relieve increasingly serious environmental problems (e.g., gas exhaust contaminants triggering the formation of acid rain that can damage fragile ecological systems). Toward this end, novel metal‐organic frameworks (MOFs)‐based sorbent materials are designed and synthesized with distinct hard and soft metal building units, specifically {[Yb6Cu12(OH)4(PyC)12(H2O)36]·(NO3)14·xS}n (QUST‐81) and {[Yb4O(H2O)4Cu8(OH)8/3(PyC)8(HCOO)4]·(NO3)10/3·xS}n (QUST‐82), where H2PyC = 4‐Pyrazolecarboxylic acid. Exploiting the hard/soft duality, it is shown that the more stable QUST‐82 can preserve desulfurization efficiency in the presence of competing nitrogen‐containing contaminate. In addition, thermodynamically controlled single‐crystal‐to‐single‐crystal (SC–SC) phase transition is uncovered from QUST‐81 to QUST‐82, and in turn, mechanistic features are probed via X‐ray diffraction, inductively coupled plasma atomic emission spectroscopy, and ab initio molecular dynamics simulations.
Identifying leukemia‐associated immunophenotype‐based individualized minimal residual disease in acute myeloid leukemia and its prognostic significance
Authors: Sui Jing‐Ni , Chen Qiu‐Sheng , Zhang Yun‐Xiang , Sheng Yan , Wu Jing , Li Jun‐Min , Weng Xiang‐Qin , Chen Bing 
Published: February 2019

AbstractBased on the leukemia‐associated immunophenotypes (LAIPs), minimal residual disease (MRD) related to the outcome can be detected by multiparameter flow cytometry in acute myeloid leukemia (AML) patients. Although 0.1% was commonly used as a cutoff value, measurable MRD or MRD level below 0.1% has also been associated with prognostic significance and more sensitive thresholds (<0.1%) are required for improving AML prognosis prediction. In this study, 292 adult patients diagnosed with AML (non‐M3) were enrolled, 36 kinds of LAIPs were identified, and the baseline expression levels in normal or regenerating bone marrows of each kind of LAIP were established, which ranged from <2.00 × 10−5 to 5.71 × 10−4. The baseline level of each LAIP was considered as the individual threshold for MRD assessment. MRD statuses stratified by 0.1% and individual threshold were termed as 0.1%‐MRD and individual‐MRD, respectively. The patients of individual‐MRDneg showed significantly better survival compared with those of 0.1%‐MRDneg/individual‐MRDpos or 0.1%‐MRDpos. Multivariate analysis showed that when time points of complete remission, post the first and second consolidation courses, were considered, only individual‐MRD post second consolidation presented independent prognostic value. Notably, in patients of cytogenetic/molecular low‐risk (LR) or intermediate‐risk (IR), the individual‐MRD status could identify the patients with significantly different outcomes, while 0.1%‐MRD status could not. Furthermore, among the patients of the LR or IR group which received chemotherapy only, those with individual‐MRDneg status presented favorable survival, which was comparable with that of the patients accepted allogeneic hematopoietic stem cell transplantation (ASCT). This approach is useful in the selection of an ASCT strategy for clinical practice.
Effects of GPTMS concentration and powder to liquid ratio on the flowability and biodegradation behaviors of 45S5 bioglass/tragacanth bioactive composite pastes
Authors: Rasti Mahtab , Hesaraki Saeed , Nezafati Nader 
Published: February 2019

ABSTRACTInjectable composite pastes were prepared using melt‐derived 45S5 bioactive glass and tragacanth crosslinked by (3‐glycidyloxypropyl)trimethoxysilane (GPTMS). The effect of powder to liquid ratio (P:L = 1.0:2.0–1.0:2.5) and GPTMS/tragacanth ratio (0.0–1.5) on the injectability, swelling behavior, rheology, bioactivity, and cellular behavior of the pastes was investigated. Based on the results, the apparent stability and consistency of the pastes increased upon crosslinking by GPTMS. Due to the increased interactions between tragacanth and glass, a hysteresis loop with larger area was formed in the presence of GPTMS. With increase of GPTMS:tragacanth ratio from 0 to 1.5, the swelling percent dropped from 24.65 to 16.25% after 24 h and the degradation percent also went down from 27.89 to 9.11% after 21 days in the simulated body fluid. The 3‐(4,5‐dimethylthiazol‐2‐yl)‐2,5‐diphenyltetrazolium bromide assay showed a drop in the optical density of MG63 osteoblasts up to 30.07% after exposure to the GPTMS‐crosslinked composite pastes for 3 days. However, the number of viable cells gradually increased in the presence of the pastes and the cell morphology remained unchanged over time. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 47604.
Mechanical energy losses in commercial crosslinked low‐density polyethylene in the temperature range between 200 and 400 K
Authors: Lambri Osvaldo Agustín , Bonifacich Federico Guillermo , García José Ángel , Giordano Enrique David Victor , Zelada Griselda Irene , Sánchez Fernando Ariel , Mocellini Ricardo Raúl , Plazaola Fernando 
Published: February 2019

ABSTRACTAging treatments in water and in air and controlled neutron irradiation were performed on commercial crosslinked low‐density polyethylene (XLPE) for promoting different mesostructural arrangements of crystallites and crosslinking degree. Infrared spectroscopy, differential scanning calorimetry, differential thermal analysis, thermogravimetry, and dynamic mechanical analysis were used as characterization techniques. The relaxation peak related to the mobility of the grain boundaries from crystalline zones in XLPE was identified at around 260 K (at 7 Hz), involving an activation energy of 90 ± 4 kJ mol−1. The usual equation for describing the grain boundary mobility in metals involving the movement of grain boundary dislocations was adapted for studying the mobility of the boundaries among the crystalline zones, successfully. In addition, a new mechanical relaxation peak that appears at around 300 K (at 7 Hz), which involves an activation energy of 94 ± 5 kJ mol−1, was found. The driving force controlling this peak was determined as the dragging of the polymer chains at the amorphous zones adjacent to the crystals controlled by the mobility of the crystallites boundaries. The chains movement was done with break away from the physical pinning points. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 47605.
A new SiC precursor with high ceramic yield: Synthesis and characterization of CHxMeSiH2‐containing poly(methylsilane‐carbosilane)
Authors: Wang Xinliang , Chen Yi , Li Yongming , Xu Caihong 
Published: February 2019

ABSTRACTA new poly(methylsilane‐carbosilane) (PMSCS) for silicon carbide precursor was prepared using Wurtz‐type copolymerization of methyldichlorosilane (MeHSiCl2), chloromethyldichloromethylsilane (ClCH2MeSiCl2), and (dichloromethyl)methylsilane (Cl2CHMeSiH2), with (chloromethyl)methylsilane (ClCH2MeSiH2) or trimethylchlorosilane (Me3SiCl) as terminated reagent. The ceramic yield of PMSCS was markedly increased by introduction of Cl2CHMeSiH2 comonomer and capped with ClCH2MeSiH2. The H2MeSiCH2‐capped PMSCS with CHMeSiH2 structure unit in main chain produced SiC ceramic with 1.21 of C/Si atomic ratio in a ceramic yield of 78 wt % upon pyrolyzed at 1000 °C. The excellent pyrolytic properties, combining with its economical preparation, good storage stability in air, and favorable processabilty, make the CHxMeSiH2‐containing PMSCS a new cost‐effective SiC ceramic precursor. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 47618.
Electrochemiluminescence observing the surface features of Ru‐doped silica nanoparticles based on nanoparticle–ultramicroelectrode collision
Authors: Lv Xiaoqin , Li Min , Guo Zhihui , Zheng Xingwang 
Published: February 2019

AbstractWe present an innovative and sensitive electrogenerated chemiluminescence (ECL) strategy for observing the surface feature of a single silica nanoparticle based on its collision with an ultramicroelectrode (UME). As an ECL luminophore, Ru(bpy)32+ molecules are doped into silica nanoparticles. The stochastic collision events of Ru(bpy)32+‐doped silica nanoparticles (RuSNPs) can be tracked by observing the ECL ‘blips’ from the ECL reaction of Ru(bpy)32+ with a coreactant in solution. When RuSNPs collided with UME, Ru(bpy)32+ molecules that only exist near the collision site of silica nanoparticles (NPs) were electrochemically oxidized to form Ru(bpy)33+, and then emitted light, because silica NPs are insulated. The inhomogeneous properties of silica nanoparticle surfaces will produce diverse ECL blips in intensity and shape. In addition, distribution gradients from the he Ru(bpy)32+ in a silica matrix also affect ECL blips. Some information on the surface properties of silica NPs can be obtained by observation of single silica collision events.
Development and Validation of the Biotechnology Literacy Test
Authors: Açıkgül Fırat Esra , Köksal Mustafa S. 
Published: February 2019

AbstractIn this study, a ‘biotechnology literacy test’ was developed to determine the biotechnology literacy of prospective science teachers, and its validity and reliability were determined. For this purpose, 42 items were prepared by considering Bybee's scientific literacy classifications (nominal, functional, procedural, and multidimensional). The experts were asked to rate each item for content validity. As a result of the experts' evaluations, the content validity of the test was confirmed. The draft test was applied to 494 science prospective teachers. Difficulty and discrimination coefficients of items within the test were calculated to provide evidence of construct validity. It was decided to exclude 13 items as a result of item analysis. It can be said that that the test was difficult (p = 0.40) and discriminative (D = 0.41) at medium level. Finally, a valid and reliable “biotechnology literacy test” consisting of 25 multiple‐choice items each with five choices was developed in this research. © 2019 International Union of Biochemistry and Molecular Biology, 47(2): 179–188, 2019.
A smartphone‐based augmented reality system for university students for learning digital electronics
Authors: Avilés‐Cruz Carlos , Villegas‐Cortez Juan 
Published: February 2019

AbstractThe fundamental concepts of electronic devices are generally taught in the initial courses of electrical and electronics engineering. For students, it is very important to grasp the basic concepts that make computers and digital systems possible. Among these concepts, boolean algebra and logic gates stand out. In this paper, a smartphone‐based augmented reality (AR) system is proposed which helps in the adequate learning of logic gate integrated circuits (ICs). The proposed system allows the automatic identification of ICs that enables basic logic operations. It uses a smartphone and a breadboard for the identification of 7 basic logic gate ICs that are: AND gate, OR gate, NOT gate, NAND gate, NOR gate, XOR gate, and XNOR gate. The smartphone takes a picture of the electronic circuit and digitally generates a layer of virtual objects which are then mixed with the original image. The markless paradigm identifies the ICs in a typical circuit and places three objects that are: IC identification, pins information, and logic diagram information. Finally, the smartphone screen displays the image of the logic gate obtained. The entire evaluation of the AR system is presented with a technical efficiency of 97.5 and a qualitative satisfaction study.
Alerting the illusion of smoking improves quality of life in Chinese male cancer survivors
Authors: Xia Juan , Wu Peng , Wang Jiwei , Yu Jinming 
Published: February 2019

AbstractObjectiveTo examine the association between smoking status and quality of life (QOL) among cancer survivors in China.MethodsA cross‐sectional study was performed in 2725 male cancer survivors who were members of Cancer Rehabilitation Club and completed the questionnaires in 2013. Using linear regression models adjusted for confounders, we measured the association between QOL and former smokers as well as current (occasional, <10 cigarettes/day, and ≥ 10 cigarettes/day) smokers compared with never smokers.ResultsCurrent smokers were reported to have higher scores in social, role, cognitive functioning, and had lower scores in nausea/vomiting, pain, dyspnea, and insomnia (P < 0.05). Former smokers had higher global health status and experienced less appetite loss and constipation (P < 0.05). Compared with never smokers, those former smokers and current smokers had significantly high scores on the global health status, social functioning, role functioning, and cognitive functioning (P < 0.05). And they had lower scores in some aspects of symptom scale (P < 0.05). Considering the dose of smoking, the scores were increased in functional subscales and decreased in symptom subscales with the increase of tobacco use, though few variables had statistical significance. As for smoking cessation, the proportion of lung cancer survivors who quit smoking was higher than that of other types of cancer survivors.ConclusionOur study suggested the possibility that in China, where smoking prevalence is still high, continued smoking was associated with high QOL scores. The phenomenon may be obscured by some potential reasons, including subjectivity of questionnaire, special substances of cigarettes, Chinese unique culture of tobacco use, and much more. The results reminded researchers and clinicians some underlying situations among smokers in China and prompted a strong call for the implementation of a comprehensive tobacco‐control policy and specific public health educational strategies among not only lung cancer survivors but other types of cancers survivors.
How reconstructive surgery combined with physiotherapy for a painful nontraumatic patellar dislocation enabled a woman with Rett syndrome to become pain free and remain physically active: A case report
Authors: Svedberg Lena , Herngren Bengt , Michno Piotr 
Published: February 2019

Key Clinical MessageThe effects of orthopedic measures, with the exception of scoliosis surgery, are rarely described in individuals with Rett syndrome. In this case, treating a painful dislocation of the patella with combined orthopedic and physiotherapeutic measures enabled a woman with Rett syndrome to become pain free and remain physically active.
Magnetic resonance cholangiopancreatography for afferent loop syndrome
Authors: Takata Kazuhide , Anan Akira , Umeda Kaoru , Sakisaka Shotaro 
Published: February 2019

Key Clinical MessageAfferent loop syndrome (ALS) is a rare but serious complication after gastrectomy. When a patient is diagnosed with ALS using computed tomography, magnetic resonance cholangiopancreatography may help in delineating the exact cause of ALS and determining an appropriate management.
One‐Pot Synthesis of DOX@Covalent Organic Framework with Enhanced Chemotherapeutic Efficacy
Authors: Liu Sainan , Hu Chunling , Liu Ying , Zhao Xueyan , Pang Maolin , Lin Jun 
Published: February 2019

AbstractCovalent organic frameworks (COFs) have attracted great attention across diverse research fields. However, only a few reports about the biomedical application of COFs are found in the literature. Attributed to the highly porous and tunable structure, as well as good thermal stability, COFs show great potential as drug carriers for chemotherapy. In this work, doxorubicin (DOX) was successfully in situ loaded into a COF by a one‐pot method for the first time. The resultant DOX@COF platform exhibited high drug‐loading capacity (32.1 wt %) and pH‐responsive release property. In vitro and in vivo experiments demonstrated its good biocompatibility and enhanced antitumor efficacy.
Comparative Study of Photoswitchable Zinc‐Finger Domain and AT‐Hook Motif for Light‐Controlled Peptide–DNA Binding
Authors: Murawska Gosia M. , Poloni Claudia , Simeth Nadja A. , Szymanski Wiktor , Feringa Ben L. 
Published: February 2019

AbstractDNA–peptide interactions are involved in key life processes, including DNA recognition, replication, transcription, repair, organization, and modification. Development of tools that can influence DNA–peptide binding non‐invasively with high spatiotemporal precision could aid in determining its role in cells and tissues. Here, the design, synthesis, and study of photocontrolled tools for sequence‐specific small peptide‐DNA major and minor groove interactions are reported, shedding light on DNA binding by transcriptionally active peptides. In particular, photoswitchable moieties were implemented in the peptide backbone or turn region. In each case, DNA binding was affected by photochemical isomerization, as determined in fluorescent displacement assays on model DNA strands, which provides promising tools for DNA modulation.