bluuebunny/crossref_metadata_2025_split huggingface dataset:
A qualitative study of barriers and opportunities for concussion communication and management among parents of youth sports athletes
Authors: Sarmiento Kelly , Donnell Zoe , Bell Elizabeth , Tennant Bethany , Hoffman Rosanne 
Published: July 2019

Background Concussion, a commonly reported injury among young athletes, can lead to short- and long-term physical, cognitive, emotional, and sleep-related symptoms. Parents are in a unique position to help identify a possible concussion and to support an athlete’s recovery. Methods This qualitative study used a focus group methodology to explore five research questions focused on two main topics: (1) parents’ perception of concussion and (2) parent–athlete communication. Two authors independently reviewed notes from each of the focus groups and then generated a list of emerging themes related to five research questions. Results Parents in this study valued and were interested in discussing concussion with their athletes. However, parents were uncertain about their role in promoting concussion safety and often rely on coaches to communicate with athletes about concussion reporting and recovery. Participants described barriers their athletes may face in concussion reporting and suggested strategies to improve communication about both reporting and recovery. Conclusion Concussion education efforts may benefit from promoting specific actions parents can take to prevent concussion and how to communicate effectively with their child about reporting a possible concussion.
Three-dimensional analysis of acetabular cup orientation and an evaluation of the relationship with pelvic sagittal parameters
Authors: Sahin Ali , Simsek Mehmet Emin , Gursoy Safa , Akkaya Mustafa , Isik Cetin , Bozkurt Murat 
Published: July 2019

Background: This study aimed to evaluate the effect of total hip arthroplasty (THA) on sagittal pelvic parameters and to evaluate the effect of sagittal pelvic parameters on acetabular cup orientation. Methods: The study included 86 patients who underwent THA for a diagnosis of unilateral coxarthrosis between 2011 and 2015. Measurements were taken of the preoperative and postoperative acetabular cup inclination (ACI), anteversion, and sagittal pelvic parameters. The effect of THA on sagittal pelvic parameters and the effects of the sagittal pelvic parameters on acetabular cup orientation were investigated. Results: The sagittal pelvic tilt values calculated were mean 9.7° ± 6.3° (2°; 23°) preoperatively and 11.0° ± 6.1° (2°; 25°) postoperatively. The increase in postoperative pelvic incidence (PI) values was determined to be statistically significant ( p < 0.05). The preoperative PI values had no significant effect on ACI, but in cases with high preoperative PI values, a tendency to high anteversion values was determined. The mean inclination values were found to be 40.2° ± 11.0° in the low PI group, 41.7° ± 7.4° in the normal PI group, and 44.1° ± 8.3° in the high PI group. As no increase in inclination values was observed with an increase in PI values, no statistical correlation was determined ( p = 0.343). Average of anteversion values in the low PI group was 9.2° ± 13.7°, in the normal PI group 19.3° ± 10.5°, and in the high PI group 21.1° ± 12.5°. The difference between the groups was statistically significant ( p = 0.001). Conclusion: Evaluating the results of this study, it can be concluded that varying PI values do affect the acetabular cup anterversion in THA. So, preoperative assessment of PI values is important in preventing postoperative acetabular cup malposition.
Long-term safety and activity of NY-ESO-1 SPEAR T cells after autologous stem cell transplant for myeloma
Authors: Stadtmauer Edward A. , Faitg Thomas H. , Lowther Daniel E. , Badros Ashraf Z. , Chagin Karen , Dengel Karen , Iyengar Malini , Melchiori Luca , Navenot Jean-Marc , Norry Elliot , Trivedi Trupti , Wang Ruoxi , Binder Gwendolyn K. , Amado Rafael , Rapoport Aaron P. 
Published: July 2019

AbstractThis study in patients with relapsed, refractory, or high-risk multiple myeloma (MM) evaluated the safety and activity of autologous T cells engineered to express an affinity-enhanced T-cell receptor (TCR) that recognizes a peptide shared by cancer antigens New York esophageal squamous cell carcinoma-1 (NY-ESO-1) and L-antigen family member 1 (LAGE-1) and presented by HLA-A*02:01. T cells collected from 25 HLA-A*02:01-positive patients with MM expressing NY-ESO-1 and/or LAGE-1 were activated, transduced with self-inactivating lentiviral vector encoding the NY-ESO-1c259TCR, and expanded in culture. After myeloablation and autologous stem cell transplant (ASCT), all 25 patients received an infusion of up to 1 × 1010 NY-ESO-1 specific peptide enhanced affinity receptor (SPEAR) T cells. Objective response rate (International Myeloma Working Group consensus criteria) was 80% at day 42 (95% confidence interval [CI], 0.59-0.93), 76% at day 100 (95% CI, 0.55-0.91), and 44% at 1 year (95% CI, 0.24-0.65). At year 1, 13/25 patients were disease progression-free (52%); 11 were responders (1 stringent complete response, 1 complete response, 8 very good partial response, 1 partial response). Three patients remained disease progression-free at 38.6, 59.2, and 60.6 months post-NY-ESO-1 SPEAR T-cell infusion. Median progression-free survival was 13.5 months (range, 3.2-60.6 months); median overall survival was 35.1 months (range, 6.4-66.7 months). Infusions were well tolerated; cytokine release syndrome was not reported. No fatal serious adverse events occurred during study conduct. NY-ESO-1 SPEAR T cells expanded in vivo, trafficked to bone marrow, demonstrated persistence, and exhibited tumor antigen-directed functionality. In this MM patient population, NY-ESO-1 SPEAR T-cell therapy in the context of ASCT was associated with antitumor activity. This trial was registered at www.clinicaltrials.gov as #NCT01352286.
Three-dimensional radiologic–pathologic correlation of medication-related osteonecrosis of the jaw using 3D bone SPECT/CT imaging
Authors: Miyashita Hidetaka , Kameyama Kaori , Morita Mayu , Nakagawa Taneaki , Nakahara Tadaki 
Published: July 2019

Objectives: The aim of this study was to assess a three-dimensional (3D) correlation between preoperative 3D bone single photon emission CT (SPECT)/CT, which allows the visualization of radiotracer uptake on 3D volume-rendered CT images, and histopathological characteristics in the medication-related osteonecrosis of the jaw (MRONJ). Methods: We conducted a full histopathological assessment of the resected jaws in four patients with Stage 2 or 3 MRONJ. The pathologic results were classified as follows: necrosis without any tissue vascularity (N + V-), necrosis with both vascularity and acute inflammatory cell infiltration due to bacterial infection (N + V+I+), necrosis with regenerative vasculature but no inflammatory cell infiltration (N + V+I-), and chronic inflammation without massive necrosis (N-V +I+). These classifications were correlated with imaging results. Results: The N + V- areas visually represented the area of necrotic bone exposed to the oral cavity and were consistent with defect area of radioisotope uptake in SPECT/CT. The N + V- areas were surrounded by the N + V+I + areas where increased radiotracer uptake was clearly seen. Also, abnormal uptake was found in both of the N + V+I- and N-V +I+ areas. The extensive surgical resections from necrotic core to bloody viable margins were performed in all cases, although one had the recurrence of MRONJ at the margin showing abnormal uptake that histologically represented the N + V+I- area. Conclusions: Radiologic–pathologic correlation of MRONJ could be achieved using 3D SPECT/CT. The presence of regenerative vascularity with necrosis or inflammation seemed to determine bone metabolism in MRONJ. The recurrence of MRONJ was observed in one case, and 3D SPECT/CT had preoperatively depicted the recurrence site.
Crystal structure of (μ2-oxido)-bis(N,N′-o-phenylenebis(salicylideneiminato))diiron(III) — N,N′-dimethylformamide, C47H43Fe2N4O9
Authors: Ya Li , Xiangqing Fang , Junyi Liu , Chi Dong , Liguo Yang 
Published: July 2019

Abstract
C47H43Fe2N4O9, orthorhombic, Pbca (no. 61), a = 24.6961(8) Å, b = 14.0952(5) Å, c = 24.696(3) Å, V = 8596.6(4) Å3, Z = 8, R
gt(F) = 0.0374, wR
ref(F
2) = 0.1209, T = 296(2) K [1–3].
Evaluation of the adhesion performance of latex-starch mixtures to calcium carbonate surfaces
Authors: Hashemi Najafi Seyyed Mohammad , Bousfield Douglas W. , Tajvidi Mehdi 
Published: July 2019

Abstract
A number of studies have reported on the mechanical properties of paper coatings and the influence of various parameters on cracking at the fold. Failure at the pigment-binder interface is important to understand because it likely controls how coating layers fail or crack in different applications and processes. In this study, a model system of a calcium carbonate surface in contact with latex and starch binders was used to evaluate the interfacial bonding performance affecting failure in tensile mode. Samples of calcium carbonate marbles with binder films between them were tested in tensile tests and the results were compared with those of pure binder films. In addition, contact angles of calcium carbonate, latex and starch were measured. The failed surfaces were analyzed using Raman spectroscopy and scanning electron microscopy (SEM). All sample involving the calcium carbonate surface failed at a maximum stress of around 25 % compared to that of pure films. Samples that contained starch exhibited larger maximum stress values than pure latex system. The strain at failure for these samples did not depend on the starch content to a large extent. While Raman results did not indicate any residual latex particles on the adhesively failed surfaces, SEM microscopy confirmed that at least part of the failure was still cohesive because regions of binder were present on the surface.
Penerapan Fungsi Actuating Pesantren dalam Upaya Pembinaan Tahfidz
Authors: Sakinah Nur 
Published: July 2019

The purpose of this research is to find out how the implementation of actuating function in the effort of fostering tahfidz in Pesantren Bina Insan Mulia Al-Mawahib. The method used in this research is descriptive method. The data collection technique is through obsevation, interview and documentation study. From this research, it is found that actuating process conducted by Pesantren Bina Insan Mulia Al Mawahib: that is holding recruitment of santri before entering pesantren, implementation of coordination, mobilization and resource allocation, giving motivation, addition of rote, division of tahfidz santri group, giving sanction for santri who do not reach the target, the targeting of memorization, the supervision of tahfidz development, the tahfidz superior program in pesantren, the determination of the target number of memorization in every semester, the supervision of the tahfidz coach towards the students and the development of tahfidz's guidance to the students, the excellent program in memorizing the Quran. the existence of constraints tahfidz builder, supporting factors or supporting santri in memorizing the Quran. Further Efforts made in Pesantren Bina Insan Mulia Al Mawahib in coaching tahfidz against santri for the implementation of tahfidz coaching goes well. The effort always strives to foster tahfidz while maintaining the quality and quantity as well as the method of fostering tahfidz such as (1) Ngaji together, (2) sualan, (3) sima'an (4) tasmi and (5)talaqqi. Tujuan dari penelitian ini adalah untuk mengetahui bagaimana penerapan fungsi actuating dalam upaya pembinaan tahfidz di Pesantren Bina Insan Mulia Al-Mawahib. Metode yang digunakan dalam penelitian ini adalah metode deskriptif. Adapun teknik pengumpulan datanya adalah melalui kegiatan obsevasi, wawancara dan studi dokumentasi. Dari penelitian ini diperoleh informasi bahwa proses actuating yang dilakukan pesantren Bina Insan Mulia Al Mawahib: yaitu mengadakan perekrutan santri sebelum masuk ke pesantren, pelaksanaan koordinasi, mobilisasi dan alokasi sumber daya, pemberian motivasi, penambahan hafalan, pembagian kelompok santri tahfidz, pemberian sanksi bagi santri yang tidak mencapai target, penentuan target hafalan, pengawasan pembinaan tahfidz, program unggulan tahfidz di pesantren, penentuan jumlah target hafalan dalam setiap semester, pengawasan dari Pembina tahfidz terhadap santri dan pengembangan pembinaan tahfidz terhadap santri, program unggulan dalam menghafal Al Quran. adanya kendala pembina tahfidz, faktor pendukung atau penunjang santri dalam menghafal Al Quran. Selanjutnya Upaya-upaya yang dilakukan di Pesantren Bina Insan Mulia Al Mawahib dalam pembinaan tahfidz terhadap santri agar pelaksanaan pembinaan tahfidz berjalan dengan baik. Upaya tersebut senantiasa berupaya untuk membina tahfidz dengan tetap menjaga kualitas dan kuantitas juga metode dalam pembinaan tahfidz seperti (1) ngaji bersama,(2) sualan,(3)sima’an(4) tasmi dan(5) talaqqi.
RETROSPECTIVE 6 YEARS STUDY OF MATERNAL OUTCOME AFTER CAESAREAN HYSTERECTOMY IN SULAIMANI MATERNITY TEACHING HOSPITAL
Authors: Fattah Chro , Mohamed Shanyar 
Published: July 2019

Background
Caesarean hysterectomy is one of the surgical procedures that performed as a last choice for saving mothers life challenging all obstetricians about the exact management between saving life or saving the fertility with the available resources.
Objectives
This study was conducted to determine incidence, associated factors and maternal morbidity and mortality after cesarean hysterectomy.
Patients and Methods
It is a descriptive retrospective study conducted over 6 years from 2012 to 2017 included all caesarean (peripartum) hysterectomies performed in Sulaimani maternity teaching hospital beyond 24 week gestation. File records was used to determine the data regarding the research. We used “IBM SPSS Statistics version 20” for the analysis of the data.
Results
The prevalence of cesarean hysterectomy was 0.56/1000 total deliveries. The ages were between 35-40 years, risk factors of last pregnancy were obesity, grand multiparity, and previous C\S were found in 55%, 65%, and 65% respectively. For antepartum and intrapartum risk factor antepartum hemorrhage and postpartum hemorrhage represented 20% and 30% respectively. Most of their pervious pregnancies delivered by (C/S) and 20% had history of 3 previous C/S, and 25% their pregnancy was complicated by gestational diabetes mellitus. Regarding intraoperative management blood product, B- Lynch suture, internal iliac artery ligation, intrauterine balloon, and recombinant factor 7 used in almost all cases. In follow up cases for 1 year chronic pelvic pain was most frequent complaint in 20% and ovarian cyst was also found in about 25%.
Conclusion
Prevalence of cesarean hysterectomy incidence was 0.56/1000 total deliveries. The significant risk factors were obesity, grand multiparity, and history of previous C\S sections. Regarding maternal age is not far from the international age related to cesarean hysterectomy.
ACUTE RADIOTHERAPY-INDUCED SKIN REACTIONS: THREE MONTHS CLINICAL OBSERVATION AT A SINGLE INSTITUTE IN KURDISTAN–IRAQ
Authors: Kareem Ranjdar , Saeed Mohammed , Mula-Hussain Layth 
Published: July 2019

Background
Radiotherapy Induced Skin Reactions (RISR) are common side effects of external-beam radiotherapy (EBRT). They can be acute or chronic and may require special attention by the care givers. It is not yet studied in our region.
Objectives
To observe the clinical manifestations of randomly collected patients, whom will take RT in a single radiation oncology center, over a period of three months post the first RT fraction.
Methods
Fifty patients with different types of cancers participated, whom have been treated with EBRT for different intentions. Ten sessions of clinical observation applied, started before the 1st EBRT dose and extended to 12th week, using Skin Toxicity Assessment Tool (STAT).
Results
It involved 35 females and 15 males. Full assessment was amenable for 49 patients. Breast cancer patients were half of the cohort. Seventy percent of participants received a total dose of 4001-6000 centyGray (cGy). Ninety four percent got at least one of RISRs ranging from faint erythema 94%, itching 82%, hyperpigmentation 78%, dry desquamation 74%, burning 66%, bright erythema 62%, wet desquamation 58%, tenderness 30%, and ulceration 6%.
Conclusion
Acute RISR is a very common side effect of EBRT in our population. Erythema was the most frequent, while ulceration was the lowest. Total dose was directly proportional to the severity of damage.
COMPARING CORONARY ANGIOGRAPHIC FINDINGS AMONG DIABETIC AND NON-DIABETIC PATIENTS
Authors: Mahwi Taha , Mirza Aram , Abdalwahid Redwan 
Published: July 2019

Background
Diabetes mellitus is worldwide metabolic and vascular problem characterized by hyperglycemia. People with diabetes have a 4-fold-greater risk for having a cardiovascular disease than people without diabetes.
Objectives
To look at the effect of diabetes mellitus on the number of the coronary vessels involved and the extent of coronary artery disease and the association of different socio-demographic characteristics in respect to diabetic and non-diabetic patients.
Patients and Methods
A cross-sectional observational study was conducted on two hundred patients who were admitted to Sulaimani Cardiac Teaching Hospital between March and September 2018. Half of the cases were diabetic and the other half were non-diabetic.
Results
Among the total of 200 patients involved in the study, 59% were males and 41% were females. Mean age was 60.98±10.60. Average HbA1c% value for DM patients was 8.46±2.10. Coronary angiography results in diabetic patients were positive for more multi vessel disease than non-diabetic patients (53% vs. 39%) (p value = 0.005). Diabetic patients were more likely to be hypertensive than non-diabetic patients (59% vs. 40%) (p value=0.001).
Conclusion
Diabetes mellitus is a risk factor for coronary artery disease and diabetic patients had more extensive CAD, which is comparable to other studies done in different countries.
Развитие идей о способности субъекта к самостоятельному выбору и современная дискуссия о социальной субъектности
Authors: Дарган Анна Александровна 
Published: July 2019

<p>В данной статье осуществляется анализ теоретических концепций социологов Запада и России, посвященных социальной субъектности. Доминантой, определяющей различия данных концепций, является рассмотрение социальной субъектности как качества личности или качества субъекта.</p><p>Социальная субъектность как качество личности рассматривается через обладание личностью совокупности социально-психологических характеристик, которые определяют ее способность осуществлять сознательный самостоятельный выбор в поле социальных отношений, выстраивать ценностное отношение к важнейшим сторонам общественной жизни и планировать свою жизненную траекторию (С. И. Григорьев, Л. Д. Демина, Е. Ю. Леонова, О. Ф. Ларионова). Рассмотрение социальной субъектности как качества личности делает возможным его двухуровневую дифференциацию, а также открывает перспективы изучения механизмов формирования определенного типа социальной субъектности. Ведь при таком подходе социальная субъектность может иметь определенное значение как для самого индивида, так и для общества в зависимости от того, какой он сделал ценностный выбор жизненной стратегии самореализации.</p><p>Социальная субъектность как качество субъекта имеет другое определение: это способность субъекта быть творцом социальной реальности, выражающаяся в его способности сделать выбор и далее реализовать его в поле социальных отношений (Вал. А. Луков, Ю. А. Зубок, В. И. Чупров, Г. З. Нафикова). В рамках данного подхода социальная субъектность может быть рассмотрена на двух уровнях: индивидуально-личностном уровне и групповом уровне, когда субъектом выступает не отдельный человек, а социальная группа. В этом случае социальная субъектность определяется двумя детерминантами: внутренними факторами, качествами субъекта, определяющими его способность сделать выбор в поле социальных отношений; внешними условиями, которые позволяют ему реализовать данный выбор.</p>
Synthetic leu-enkefalin analogue prevents activation of neutrophils induced by a bacterial component
Authors: Grebenchikov O. A. , Shabanov A. K. , Kosov A. A. , Skripkin Yu. V. , Yavorovsky A. G. , Likhvantsev V. V. 
Published: July 2019

Background: Neutrophil activation is a mandatory stage and a sensitive marker of systemic inflammatory response. The development of this condition is associated with subsequent multiple organ failure which is the main indication for the patients stay in the intensive care unit. The search for drugs that could prevent the development of systemic inflammatory response and reduce mortality remains an urgent task of anesthesiology/resuscitation.Aim: To study the anti-inflammatory effect of dalargin, a synthetic analogue of lei-enkephalin, on human neutrophils in vitro.Materials and methods: The study was performed on blood neutrophils isolated from 5 healthy donors. A proportion of neutrophils were activated by 10 mkM formil-Met-Leu-Pro (fMLP) and 100 ng/mL lipopolysaccharide (LPS) with subsequent assessment of their activity by fluorescent antibodies to the degranulation markers CD11b and CD66b. Thereafter intact and activated neutrophils were treated with dalargin solution at concentrations of 50 and 100 mcg/mL.Results: Dalargin at 100 mcg/mL reduced the expression of CD11b molecules on the surface of intact neutrophils by 5.5-fold (p=0.008). On the contrary, LPS at a dose of 100 ng/mL increased the expression of the same molecules by 46% (p=0.08). The addition of dalargin at 50 mcg/mL to LPS-activated neutrophils reduced the expression of CD11b molecules (p=0.016). The addition of dalargin at 50 mcg/mL to fMLP-activated neutrophils significantly (p=0.008) reduced the expression of CD11b molecules and reversed their expression virtually to the level of the control. The addition of dalargin at 100 mcg/mL to neutrophils activated by fMLP at 10 mkM reduced the expression of CD11b on their surface to a level below the control by 23% (p=0.08).Conclusion: Dalargin at the studied concentrations has an anti-inflammatory effect on both intact and pre-activated bacterial components of neutrophils, thus inhibiting the process of activation and degranulation in a dose-dependent manner.
Prevention of epileptogenesis as a future strategy for the treatment of epilepsy
Authors: Bragin A. G. 
Published: July 2019

Epilepsy affects more than 70 million people worldwide. From 30 to 40% of the patients are resistant to existing medication. This paper describes the current state of the treatment of epilepsy and proposes a future approach to preventative treatment at earlier stages of epileptogenesis. For preventative treatment biomarkers are needed that predict the development of epilepsy at its earlier stages. Pathological high frequency oscillations are the only acceptable biomarker of epileptogenesis. However, the main limitation of this biomarker is the necessity of implanting of recording electrodes. The search for noninvasive biomarkers of epileptogenesis is one of the hot topics in epilepsy research. There are two potentially interesting directions in this area: search for inflammatory biomarkers in the peripheral blood and analysis of different parameters of imaging methods. In this paper we present approaches for identification of potential epileptogenesis biomarkers by magnetic resonance imaging. Some of magnetic resonance imaging parameters correlate with the existence of pathological high frequency oscillations, may indirectly reflect ongoing inflammation process in the brain and be potential biomarkers of epileptogenesis.