bluuebunny/crossref_metadata_2025_split huggingface dataset:
Contribution of local knowledge in cocoa (Theobroma cacao L.) to the well‑being of cocoa families in Colombia: a response from the relationship
Authors: Gutiérrez Garcia Gustavo Adolfo , Gutiérrez-Montes Isabel , Suárez Salazar Juan Carlos , Casanoves Fernando , Gutiérrez Suárez David Ricardo , Hernández-Núñez Héctor Eduardo , Flora Cornelia Butler , Sibelet Nicole 
Published: November 2024

Abstract
The concept of well-being of rural families is part of a theory under construction in which new theoretical elements are constantly being incorporated. This research aims to determine the influence of farmers’ knowledge on the well‑being of cocoa growing families in the departments of Santander, Huila, Meta and Caquetá, Colombia. Four categories of farmers were identified with different levels of knowledge in the management of cocoa cultivation obtained through a cluster analysis. The well-being of cocoa farmers, understood as the balance in the capital endowment of rural households, was obtained through the application of a semi-structured interview with 49 variables of human, cultural, social, political, natural, built, and financial capitals. The results show that cocoa knowledge is heterogeneous in the study area, with a slight improvement towards harvesting, post-harvest and transformation links. There is a positive relationship between cocoa knowledge and the well-being of cocoa farming families. Thus, producers with greater integral knowledge, with emphasis on post-harvest and bean transformation links, showed greater well-being. The Random Forest analysis identified that human capital (political, social, human, and cultural) made the greatest contribution to well-being. The findings show that cocoa knowledge contributes to the well-being of rural households to the extent that it favors vertical relationships (linkages with local governments) and horizontal relationships of producers (participation of association managers, sharing knowledge with friends, neighbors and partners, and cocoa training).
Marine genetic resources as common heritage of mankind under the BBNJ Agreement; the international community toward a pragmatic benefit-sharing approach?
Authors: Taghizadeh Zakieh 
Published: November 2024

Abstract
Marine biological diversity, and more specifically, marine genetic resources in areas beyond national jurisdiction are valuable resources that belong to all of humanity and need to be preserved for future generations. The new landmark BBNJ Agreement, also known as the “High Seas Biodiversity Treaty”, after all the intensive negotiations revolving around the legal status of MGRs, recognized that the conservation and sustainable use of these resources are to be achieved through the “Common Heritage of Humankind” as a guiding principle under Article 7 of the BBNJ Agreement. The key consideration in the following article acknowledges a paradigm shift from the CHM towards a more pragmatic benefit-sharing regime and whether all component parts of the CHM principle, including sustainable equity and more specifically, inter-generational and intra-generational equity are sufficiently addressed in the BBNJ Agreement. The following research suggests that a proper application of the common heritage of mankind principle, along with all its constituent elements, including equitable benefit-sharing, shared stewardship, sustainable management and inter-generational equity, guarantees a comprehensive balance between distributive justice and conservation approaches to marine genetic resources while serving the legitimate interests of present and future generations.
Extreme value methods for estimating rare events in Utopia
Authors: André Lídia Maria , Campbell Ryan , D’Arcy Eleanor , Farrell Aiden , Healy Dáire , Kakampakou Lydia , Murphy Conor , Murphy-Barltrop Callum John Rowlandson , Speers Matthew 
Published: November 2024

AbstractTo capture the extremal behaviour of complex environmental phenomena in practice, flexible techniques for modelling tail behaviour are required. In this paper, we introduce a variety of such methods, which were used by the Lancopula Utopiversity team to tackle the EVA (2023) Conference Data Challenge. This data challenge was split into four challenges, labelled C1-C4. Challenges C1 and C2 comprise univariate problems, where the goal is to estimate extreme quantiles for a non-stationary time series exhibiting several complex features. For these, we propose a flexible modelling technique, based on generalised additive models, with diagnostics indicating generally good performance for the observed data. Challenges C3 and C4 concern multivariate problems where the focus is on estimating joint probabilities. For challenge C3, we propose an extension of available models in the multivariate literature and use this framework to estimate joint probabilities in the presence of non-stationary dependence. Finally, for challenge C4, which concerns a 50-dimensional random vector, we employ a clustering technique to achieve dimension reduction and use a conditional modelling approach to estimate extremal probabilities across independent groups of variables.
Mapping the emotions of racialised international students and the politics of exclusion in higher education
Authors: Hu Mei , Moskal Marta , Read Barbara 
Published: November 2024

AbstractThe concerns of power and recognition regarding international students’ experiences are largely absent from the literature, with a discourse of social inclusion framing the focus. Social inclusion within an economically centred view of international education ignores issues of ‘difference’ and celebrates ‘diversity’ as a key aspect. Such an approach lacks a discussion of power concerns; diversity is portrayed as unproblematic, whereas difference is something that needs to be managed by standardization and monitoring procedures. The article contributes to the recent decolonial approaches to racialised international students by showing how the subtle dynamics of power relations within higher education influence international students’ emotional experiences. It draws on longitudinal data collected from 25 Chinese international postgraduate students over a 1-year period in the UK. While employing Ahmed’s framework of affective economies together with Foucault’s concepts of discourse and power, it investigates the intricate connections between international students’ emotional experiences and prevailing institutional discourses of neoliberalism, individualism and postcolonialism. It elucidates how emotions work as tools to both constrain and enable agency in relation to the thoughts and actions of international students, influencing the perceived eligibility and appropriateness of their behaviours within the ‘White’ UK higher education space.
Trajectories of Personal Growth among First-Time Parents: The Predicting Role of Coping Flexibility and Parental Distress
Authors: Taubman – Ben-Ari Orit , Ramon Dan , Ben-Yaakov Ofir 
Published: November 2024

Abstract
Objectives
The study aimed to identify different trajectories of personal growth (PG) following the transition to parenthood, as well as factors that predict these trajectories.

Method
Parents (n = 788) completed self-report questionnaires in three phases: when infants were 3–12 months-old, six months later and again six months later. Latent Class Growth Analyses (LCGA) and Growth Mixture Modeling (GMM) were used to identify latent subgroups of individuals based on common trajectories of PG. Stepwise multinominal regression models were used to identify significant determinants of personal growth trajectories.

Results
Four trajectories were found: (1) constructive; (2) high-stable; (3) low-stable; and (4) moderately delayed. Being a woman and higher coping versatility were related to the high-stable trajectory, higher economic status was related to the low-stable trajectory, and higher parental distress was related to the moderately-delayed trajectory.

Conclusions
The study offers insights into growth in first-time parents of young infants by distinguishing between four trajectories and showing that economic status, as well as the psychological variables of parental distress and coping flexibility, might differentiate between different growth patterns. The results contribute to the theoretical understanding of the complex experience of personal growth, which, in turn, can serve professionals in the design of appropriate personalized interventions for new parents.
Neuroprotective Effect of Maresin-1 in Rotenone-Induced Parkinson’s Disease in Rats: The Putative Role of the JAK/STAT Pathway
Authors: Khodir Suzan A. , Sweed Eman M. , Faried Manar A. , Abo Elkhair Doaa M. , Khalil Marwa M. , Afifi Khaled Hatem , El Agamy Dalia Fathy 
Published: November 2024

Abstract
Exposure to rotenone results in similar pathophysiological features as Parkinson’s disease. Inflammation and oxidative stress are essential to PD pathogenesis. Maresin-1 has potent anti-inflammatory properties and promotes the regression of inflammation function. The current study aimed to evaluate the protective effects of Maresin-1 (MaR1) in rotenone (ROT)-induced PD and whether this protective role is associated with the initiation of the Janus kinase (JAK)-signal transducers and activator of transcription (STAT) signaling pathway. Thirty male Wister rats were classified into control, ROT-treated, and ROT + MaR1-treated groups. Rats underwent rotarod, open field, grip strength, and stepping tests as part of their motor behavioral evaluation. Serum glial cell-derived neurotrophic factor (GDNF) and striatal dopamine, acetylcholine, malondialdehyde (MDA), reduced glutathione (GSH), TNF-α, IL-6, and IL-1β were evaluated. Expression of JAK1 and STAT3 genes was assessed in striatum. Then, the tissue was subjected to histological and immunohistochemical evaluation for caspase-3, GFAP, and NF-kB. The administrated group with rotenone showed significant motor behavioral impairment. This was accompanied by reduced levels of GDNF and dopamine and increased levels of acetylcholine, as well as augmented oxidative stress and inflammatory biomarkers and reduced antioxidant activity. Inflammatory pathways (JAK1/STAT3, caspase-3, and NF-kB) were upregulated. Histopathological changes and upregulation in GFAP immunopositive reaction were observed. Remarkably, MaR1 treatment effectively alleviated behavior, histopathological changes, and biochemical alterations induced by ROT. MaR1 exerts protective effects against ROT-induced PD by its anti-inflammatory, antiapoptotic, and antioxidant properties. MaR1 mechanisms of action may involve modulation of pathways such as JAK/STAT.
Aesthesis, noesis, or both? Enactivism meets representationalism in aesthetics
Authors: Kiianlinna Onerva 
Published: November 2024

Abstract
Two types of systemic models of the mind – the enactivist and the representationalist model – are often depicted as contradictory and mutually exclusive. In this article, I investigate whether they can meaningfully coexist in a viable account of forming aesthetic judgments. I argue that the two models can simultaneously contribute to the understanding of aesthetic judging as an affective cognitive process. First, I clarify why the main disagreement between the models does not apply to the case of aesthetic judging. Second, I trace a possible path for how the two models could be merged in the field of aesthetics. My main argument draws on the idea that perceiving aesthetic value does not belong to basic cognition that can be seen as either enactive or representational, and that hence we can choose to pick the best of both worlds. In other words, we can and indeed should incorporate aspects of both models to do justice to the phenomenon of aesthetic judging. Perceiving aesthetic value requires subjective, or embodied, metacognitive evidence. This representational enactivism entails that the aesthetic subject can be seen as an emergent functional system while the functional sub-systems that constitute the subject can be characterized in representationalist terms.
A landscape review to identify what matters to patients with thrombotic cardiovascular diseases and patient-reported outcome instruments which can be used to capture the patient experience
Authors: Barsdorf Alexandra I. , Fastenau John , Lee Shannon , Li Xiaoyan , O’Brien Ellen , Stevenson Blue , Becker Brandon 
Published: November 2024

Abstract

Purpose
Thrombotic cardiovascular diseases profoundly impact patients’ health-related quality of life (HRQoL). However, patient-reported outcome (PRO) instruments that are disease-specific or antithrombotic-treatment focused, developed according to US Food and Drug Administration (FDA) guidance on PROs, and can be used in clinical trials, are lacking. The aim of this study was to understand concepts important to patients diagnosed with coronary artery disease (CAD) or acute coronary syndrome (ACS), atrial fibrillation (AF), or stroke who require antithrombotic treatment for reducing risk of future thrombotic events (indications being evaluated for an investigational new drug), identify PROs that measure relevant symptoms and impacts, and determine acceptability of PROs from a health technology assessment (HTA) perspective.

Methods
A landscape review, conducted between January 2009 and October 2020, included a search of qualitative literature (OVID), a review of PRO instruments using multiple sources (e.g., OVID and clinical trials databases), and a survey of HTA decisions for antithrombotic medications.

Results
The qualitative literature review identified 27 publications used to develop a high-level conceptual summary of symptoms and HRQoL impacts reported by patients. The instrument landscape review indicated that generic PROs have been utilized for thrombotic indications, but disease-specific, fit-for-purpose instruments are lacking, and the HTA review revealed that although HTA agencies discussed PRO instruments, evidence of specific recommendations was not found.

Conclusion
To ensure patients’ experiences, perspectives, and priorities are incorporated into drug development and evaluation, a core set of PROs for thrombotic indications that meet health authority guidance and are acceptable to HTA agencies is needed.
Impact of body fat composition on liver iron overload severity in hemochromatosis: a retrospective MRI analysis
Authors: Pušeljić Marijan , Stadlbauer Vanessa , Ahmadova Nigar , Pohl Maximilian , Kopetzky Michaela , Kaufmann-Bühler Ann-Katrin , Watzinger Nikolaus , Igrec Jasminka , Fuchsjäger Michael , Talakić Emina 
Published: November 2024

Abstract

Purpose
To evaluate the correlation between ectopic adipose tissue and iron overload severity in patients with hemochromatosis.

Material and methods
A retrospective cohort of 52 patients who underwent liver iron concentration quantification from January 2015 to October 2023 using a 3.0T MRI scanner. R2* relaxation times and proton density fat fraction (PDFF) were assessed for the entire liver volume and a specific region of interest (ROI) placed in the right lobe. Total body fat (TF), subcutaneous fat (SCF), intermuscular fat (IMF), and visceral fat (VSF) percentages were calculated from a single axial slice at the level of the third lumbar vertebra. Additionally, ratios of IMF-to-VSF, IMF-to-SCF, and SCF-to-VSF were calculated. Standard iron laboratory parameters were collected at least one month prior to MRI. Pearson correlation coefficient was used for correlation analysis.

Results
The mean age of participants was 53.9 ± 19.6 years. IMF positively correlated with R2* values in the ROI (p = 0.005, rs = 0.382) and entire liver (p = 0.016, rs = 0.332). Conversely, VSF negatively correlated with R2* values from the ROI (p = < 0.001, rs = − 0.488) and entire liver (p = < 0.001, rs = − 0.459). Positive correlations were also found between IMF-to-VSF and R2* of the ROI (p = 0.003, rs = 0.400) and whole liver (p = 0.008, rs = 0.364). Ferritin levels positively correlated with R2* values calculated from ROI (p = 0.002, rs = 0.417) and whole liver volume (p = 0.004, rs = 0.397). A positive correlation was noted between PDFF of the entire liver and TF (p = 0.024, rs = 0.313).

Conclusion
The percentage of Intermuscular and visceral adipose tissues correlates with the severity of liver iron overload in hemochromatosis patients.
The Effects of Microplastics on Musculoskeletal Disorder; A Narrative Review
Authors: Fusagawa Hiroyori , Youn Alex , Wilkerson Elyse , Pandya Nirav , Feeley Brian T. 
Published: November 2024

Abstract

Purpose of Review
The physical health impacts of microplastics have received increasing attention in recent years. However, limited data impedes a full understanding of the internal exposure to microplastics, especially concerning the musculoskeletal system. The purpose of this review is to summarize the recent literature regarding the effects of microplastics on the musculoskeletal system.

Recent Findings
Microplastics have been shown to cause abnormal endochondral ossification and disrupt the normal function of pre-osteoblasts, osteocyte-like cells, and pre-osteoclasts through gene mutations, endoplasmic reticulum stress induction, and reduced autophagosome formation in bone growth areas. Although there are few reports on their effects on muscle, it has been noted that microplastics inhibit energy and lipid metabolism, decrease type I muscle fiber density, impair muscle angiogenesis, cause muscle atrophy, and increase lipid deposition.

Summary
Only a few recent studies have shown that microplastics interfere with the normal function of bone growth-related cells and reduce muscle mass and quality. This review underscores the need for further research into other parts of the musculoskeletal system and studies using human tissues at the disease level.
Influence of River Discharge and Tides on the Salinity Structure at the Magdalena River Estuary
Authors: Cardona Yuley , Álvarez-Silva Óscar , Barrios Yennis , Saavedra Victor , Cáceres-Euse Alejandro , Cantero María A. , Osorio Andrés F. 
Published: November 2024

AbstractThe salinity structure in the Magdalena River estuary results from a massive river discharge and a micro-tidal regime over a narrow-deep channel. Both environmental forcings are analyzed here to assess their effects on the temporal and spatial variability of the estuarine system. We investigated long-term (seasonal to interannual) and short-term (diurnal) changes in salinity structure and circulation through in situ measurements and a 3D hydrodynamic model ensemble (21 model runs). The measurements cover low (below 10th percentile) and mean river discharge conditions. Results show that the Magdalena River estuary (MRE) behaves as a strongly stratified system during the dry season (February to April) and as a vertically homogeneous one during the wet and transitional seasons when the river plume exhibits a lift-off regime at the mouth. A river discharge threshold has been found for the estuary to lift-off regime transition, corresponding to the 30th percentile (5200 m3/s). At the seasonal scale, the salinity intrusion length in the MRE shows more reactivity to river discharge variability than other reported strongly stratified estuaries; it is reflected in the scaling factor $$n$$
n
in the relationship $$L\sim {Q}^{-n}$$

L
∼

Q

-
n

. A $$n$$
n
value of 3.9 is the best fit for the MRE; nevertheless, it follows the Schijf and Schönfeld theoretical model solution for a prismatic flat configuration. Micro tides modulate the salinity intrusion on the diurnal cycle with a more significant effect on salinity intrusion and water exchange than previously reported, particularly during low discharge conditions. The findings from measurements and model scenarios for the MRE can be broadly applied and stand for an exemplary tropical, micro-tidal, anthropogenic intervened system.
The complex story of human X chromosome inactivation
Authors: Basilicata Maria Felicia , Einsiedel Anna 
Published: November 2024

AbstractThe X and Y sex chromosomes represent one of the key cellular differences between male and female. Here, we introduce the unique, silent nature of the inactive X in female cells (and its exceptions) and summarise recent insights to the molecular processes taking place on the X chromosome. We are curious to learn how these mechanisms drive sex differences in neurodevelopmental disorders.
Modification of adipogenesis and oxidative stress by quercetin: positive or negative impact on adipose tissue metabolism of obese diabetic Zucker rats?
Authors: Kršková Katarína , Dobrócsyová Viktória , Ferenczyová Kristína , Hricovíniová Jana , Kaločayová Barbora , Duľová Ulrika , Bozorgnia Mahdi , Barteková Monika , Zorad Štefan 
Published: November 2024

AbstractReactive oxygen species (ROS) play a key role in the regulation of adipogenesis. The aim of our study was to investigate the effect of quercetin (QCT) supplement on obese adipose tissue metabolism of 30-week-old diabetic Zucker rats (ZDF), not well examined yet. QCT was administered orally at dose of 20 mg/kg body weight/day for 6 weeks. Adipocytes from subcutaneous adipose tissue (ScWAT) were isolated and their size was evaluated by light microscopy. Gene expression of adipogenic markers in subcutaneous and visceral adipose tissue was determined by real-time PCR and expression of proteins involved in lipid and glucose metabolism was determined in ScWAT by immunoblotting. Obese ZDF rats suffered from diabetes, hyperinsulinemia and had higher index HOMA-IR (Homeostatic Model Assessment for Insulin Resistance). Treatment with QCT had no significant impact on these metabolic disorders in genetic model of obesity and type 2 diabetes used in our study. Nevertheless, QCT reduced expression of inflammatory cytokine tumour necrosis factor alpha in ScWAT and also visceral adipose tissue and up-regulated expression of anti-inflammatory adiponectin in ScWAT. A shift in redox equilibrium was detected via inhibition of pro-oxidant genes by QCT. Furthermore, QCT reduced adipocyte size in ScWAT, down-regulated expression of fatty acid synthase and adipogenic markers, and moreover stimulated expression of proteolytic enzymes. These changes likely resulted in reduced fat deposition in ScWAT, which was reflected in the elevated circulated levels of free fatty acids in QCT-treated obese ZDF rats compared with obese untreated controls. This increase could, at least in part, explain why we did not observe an improvement in systemic metabolic health by QCT in our model. In conclusion, our study suggests that preventive treatment with QCT might be more effective than its administration in the stage of fully developed diabetes, and further research in this area is needed.