bluuebunny/crossref_metadata_2025_split huggingface dataset:
Modal analysis of the rotating shell structure based on Absolute Nodal Coordinate Formulation
Authors: Yu J C , Wang Q T 
Published: September 2019

Abstract
In recent years, flexible structures composed of cables, plates and shells, such as rotors and solar sails that rotate around a fixed axis have been widely used in aerospace, energy and other industrial fields. Traditional structural dynamics or multi-flexible dynamics modeling methods based on structural small deformation assumptions cannot accurately describe the nonlinear dynamics of flexible structures undergoing large-scale rotation. The Absolute Nodal Coordinate Formulation (ANCF) can accurately describe the flexible multi-body system with both large rigid motions and large deformation. Such flexible structures, while undergoing a wide range of rotational motions, are accompanied by structural vibrations that are excited by unbalanced centrifugal forces, aerodynamic forces, etc., resulting in very complex dynamic behaviors. Therefore, it is of great scientific significance and application value to dynamically model and predict the dynamic response of such flexible structures with a wide range of rotational motions. In this paper, the cylindrical shell element of ANCF proposed by Liu et al. which can realize efficient calculation is briefly introduced. The analytical expressions of elastic force and Jacobin matrix of this shell element are given. Modal analysis of shell structures modeled by ANCF cylindrical shell element and rotating around a fixed axis is studied. The effect of curvature and angular velocities on the modal of shell structures is validated.
Periodic solutions and numerical simulations for composite laminated circular cylindrical shell
Authors: Tian Y Y , Li J , Zhang W , Quan T T 
Published: September 2019

Abstract
Periodic solutions and numerical simulations for a composite laminated circular cylindrical shell under the parametric excitation of temperature are investigated in this paper. By introducing some transformations and defining a Poincaré displacement map, some results, including the existence condition for periodic solutions, least upper bound of the number of periodic solutions and the parameter control conditions, are obtained. To demonstrate the applicability and validity of our theoretical results, the phase portraits of the periodic solutions with different values of the detuning parameter are presented by numerical simulations.
Accurate analysis of steady state response of fully clamped orthotropic functionally graded rectangular plates
Authors: Fan J H , Rong D L , Tong Z Z , Zhao Z , Zhou Z H , Xu X S 
Published: September 2019

Abstract
A Hamiltonian-based method is introduced to find exact solutions for steady state forced vibration of a fully clamped orthotropic functionally graded (FG) rectangular plate. The proposed method has two major steps. Firstly, the steady state response for an FG rectangular plate with Naiver-type boundary conditions is analytically derived by a wave-based symplectic method. Subsequently, exact solutions of the fully clamped FG rectangular plate are obtained by a symplectic superposition technique. The overall procedure is systematic with a clearly defined, step-by-step derivation. The accuracy of the obtained exact solutions is highlighted in comparison with reference data. Numerical results are presented to reveal the effects of the material properties.
A rational analytical approach for buckling analysis of orthotropic double-nanoplate-systems
Authors: Rong D L , Xu C H , Zhang J L , Tong Z Z , Zhou Z H , Xu X S 
Published: September 2019

Abstract
A novel analytical Hamiltonian-based approach is proposed for buckling analysis of orthotropic double-nanoplate-systems (DNPSs) under uniaxially compression embedded in an elastic medium. In the Hamiltonian system, the governing equations for in-phase and out-of-phase buckling are established in a unified form based on Eringen’s nonlocal plate theory. The buckling analysis of the orthotropic DNPS is reduced to an eigenproblem in the symplectic space. Analytical buckling equations and buckling mode shape functions can be obtained by the symplectic eigensolutions and boundary conditions simultaneously. Comparison studies demonstrate the accuracy and efficiency of the proposed method. Key influencing factors which may benefit the design of complex 3D mesostructures are studied in detail. Some new results are given also.
Modelling and simulation for the vibration of a plate with three axes maneuvering
Authors: Zhang Y H , Liu G G , Chen S L 
Published: September 2019

Abstract
In super-maneuvering flight, aircraft often bears high accelerations and high jerks. To ensure the safety of the aircraft, it is necessary to carry out the ground test to simulate the flight loads and the responses of the aircraft. In this paper, mechanical model of the accelerations are established, the distribution characteristic of the accelerations on the plate is explored and the consistency conditions for the centrifugal load and flight load are studied. The dynamic equations of a rectangular thin plate in three-axis centrifugal environment are established by Kane method, and the responses of the plate are calculated. The model established and the results obtained can be used to reflect the responses of the plate in the flight environment.
Sensing characteristic of GPCs induced by sliding of graphene flakes
Authors: Li Zheng , Yang Qing-Sheng 
Published: September 2019

Abstract
The main aim of this paper is to investigate the effect of slide between overlapped graphene flakes on the sensing characteristic of graphene-based polymer composites (GPCs). During deformation process of GPCs, the position of the graphene flakes can be determined by using an affine transformation. The analytical solution is obtained based on the equivalent resistance formulas of series and parallel circuits. Meanwhile, the numerical simulation is also conducted through the finite element method (FEM). In addition, the consistence between the analytical solution and numerical result are proved by a simple model consisted of two-layer graphene flakes. The result shows that the gauge factor (GF) of the sensor is related to both the initial resistance and the length of the graphene flakes: the GF of the sensor decreases with the increase of the initial resistance, while the effect of the length of graphene flakes is less. Moreover, the pre-stretched GPCs have a larger sensing range which can improve the usability of the sensor.
Study on Drag Torque Characteristics of Corrugated Joint for Spacesuit under Human-Induced Loads
Authors: Wang L Y , Zhou S M , Shang K , Li D K 
Published: September 2019

Abstract
The mobility of spacesuit joints is the key factor affecting the ability of the lower-torso space service, and the drag torque of joint is an important indicator which represents the mobility of joint. Drag torque is affected by many factors, such as contact with garment, gas pressure and materials of spacesuit, which cause difficulties in theoretical calculation. A finite element simulation on drag torque characteristics of corrugated joint of spacesuit with human body is carried out. And a detailed finite element model is established which reflects the characteristics of fabric material and the actual structure of corrugated joint. Based on this model, the dynamic simulation of joint rotation in two ways of external driving and human body driving is carried out. The cause of drag torque is analyzed. Then the influence of spacing and arc length of bellows on characteristics of drag torque is studied. The results show that the sources of drag torque during rotation are the structural elastic deformation and the work to compress gas. The drag torque of joint which is in the way of human body driving is greater than by external driving, which is because the elastic deformation and work to compress gas of the former are both larger than the latter. And methods, reducing the spacing and increasing the arc length of bellows, could reduce the drag torque of joint.
Fracture analysis of cracks terminating at the interface of elastic-piezoelectric bimaterials
Authors: Yu X , Yang Z T , Xu C H , Xing Y , Zhou Z H , Xu X S 
Published: September 2019

Abstract
In this paper, the fracture behaviors of a piezoelectric-elastic bimaterial with cracks terminating at the interface are investigated by a symplectic approach. In the Hamiltonian system, the Hamiltonian forms of governing equations is derived by the Hamiltonian variational principle and a total unknown vector consisted of generalized displacements and stresses. The interface fracture problem is reduced into a symplectic eigenproblem which can be directly solved by the method of separation of variables. Thus, the total unknown vector is expanded in terms of symplectic eigenfunctions. The unknown coefficients of the symplectic series can be determined from the continuity conditions at the interface and outer boundary conditions. Consequently, exact solutions for the singular electro-elastic fields and explicit expression of electric/elastic intensity factors are obtained simultaneously. Results indicate that the electro-elastic singularities and intensity factors only depend on the first few terms of symplectic eigenfunctions with non-zero eigenvalues. Numerical examples are presented to show the effects of key influencing factors on the singularity orders and intensity factors of such interface cracks. Some new results are given also.
Lithium-related medication problems on nonpsychiatric inpatient medical units
Authors: Alastanos Jennifer N , Potter Teresa G , Crouse Ericka L 
Published: September 2019

Abstract

Purpose
Results of a study of medication-related problems (MRPs) associated with lithium use on nonpsychiatric inpatient medical units are reported.

Methods
In a single-center, retrospective study, the records of all patients hospitalized over a 21-month period who received lithium or had a documented serum lithium concentration during hospitalization were evaluated. The primary objective was to identify patient-specific factors associated with lithium MRPs on nonpsychiatric inpatient medical units. Secondary objectives included characterization of lithium MRPs. Identified MRP occurrences were further evaluated to determine if an intervention was necessary to resolve the MRP and whether or not an intervention was made.

Results
A total of 150 patients were included in the study sample. One or more lithium MRPs were identified in 85% of the patients, with a total of 255 lithium MRPs identified. None of the patient-specific factors analyzed were significantly associated with MRP occurrence. Of the 128 patients in whom a lithium MRP occurred, 92.2% (n = 118) were judged to be appropriate candidates for interventions as defined per the study definitions; among those 118 patients, such interventions were documented for only 40.7% (n = 48).

Conclusion
Lithium MRPs were found to have occurred frequently on nonpsychiatric inpatient medical units at 1 hospital. Laboratory test– related MRPs and drug–drug interactions were the most commonly identified types of MRPs. Interventions to address MRPs were not made in the majority of patients; however, interventions were more frequently made when psychiatry consultation was involved.
Graph embedding on biomedical networks: methods, applications and evaluations
Authors: Yue Xiang , Wang Zhen , Huang Jingong , Parthasarathy Srinivasan , Moosavinasab Soheil , Huang Yungui , Lin Simon M , Zhang Wen , Zhang Ping , Sun Huan 
Published: September 2019

AbstractMotivationGraph embedding learning that aims to automatically learn low-dimensional node representations, has drawn increasing attention in recent years. To date, most recent graph embedding methods are evaluated on social and information networks and are not comprehensively studied on biomedical networks under systematic experiments and analyses. On the other hand, for a variety of biomedical network analysis tasks, traditional techniques such as matrix factorization (which can be seen as a type of graph embedding methods) have shown promising results, and hence there is a need to systematically evaluate the more recent graph embedding methods (e.g. random walk-based and neural network-based) in terms of their usability and potential to further the state-of-the-art.ResultsWe select 11 representative graph embedding methods and conduct a systematic comparison on 3 important biomedical link prediction tasks: drug-disease association (DDA) prediction, drug–drug interaction (DDI) prediction, protein–protein interaction (PPI) prediction; and 2 node classification tasks: medical term semantic type classification, protein function prediction. Our experimental results demonstrate that the recent graph embedding methods achieve promising results and deserve more attention in the future biomedical graph analysis. Compared with three state-of-the-art methods for DDAs, DDIs and protein function predictions, the recent graph embedding methods achieve competitive performance without using any biological features and the learned embeddings can be treated as complementary representations for the biological features. By summarizing the experimental results, we provide general guidelines for properly selecting graph embedding methods and setting their hyper-parameters for different biomedical tasks.Availability and implementationAs part of our contributions in the paper, we develop an easy-to-use Python package with detailed instructions, BioNEV, available at: https://github.com/xiangyue9607/BioNEV, including all source code and datasets, to facilitate studying various graph embedding methods on biomedical tasks.Supplementary informationSupplementary data are available at Bioinformatics online.
Scalable inference for crossed random effects models
Authors: Papaspiliopoulos O , Roberts G O , Zanella G 
Published: September 2019

SummaryWe develop methodology and complexity theory for Markov chain Monte Carlo algorithms used in inference for crossed random effects models in modern analysis of variance. We consider a plain Gibbs sampler and propose a simple modification, referred to as a collapsed Gibbs sampler. Under some balancedness conditions on the data designs and assuming that precision hyperparameters are known, we demonstrate that the plain Gibbs sampler is not scalable, in the sense that its complexity is worse than proportional to the number of parameters and data, but the collapsed Gibbs sampler is scalable. In simulated and real datasets we show that the explicit convergence rates predicted by our theory closely match the computable, but nonexplicit rates in cases where the design assumptions are violated. We also show empirically that the collapsed Gibbs sampler extended to sample precision hyperparameters significantly outperforms alternative state-of-the-art algorithms.
Phenotypic assays in yeast and zebrafish reveal drugs that rescue ATP13A2 deficiency
Authors: Heins-Marroquin Ursula , Jung Paul P , Cordero-Maldonado Maria Lorena , Crawford Alexander D , Linster Carole L 
Published: September 2019

Abstract
Mutations in ATP13A2 (PARK9) are causally linked to the rare neurodegenerative disorders Kufor-Rakeb syndrome, hereditary spastic paraplegia and neuronal ceroid lipofuscinosis. This suggests that ATP13A2, a lysosomal cation-transporting ATPase, plays a crucial role in neuronal cells. The heterogeneity of the clinical spectrum of ATP13A2-associated disorders is not yet well understood and currently, these diseases remain without effective treatment. Interestingly, ATP13A2 is widely conserved among eukaryotes, and the yeast model for ATP13A2 deficiency was the first to indicate a role in heavy metal homeostasis, which was later confirmed in human cells. In this study, we show that the deletion of YPK9 (the yeast orthologue of ATP13A2) in Saccharomyces cerevisiae leads to growth impairment in the presence of Zn2+, Mn2+, Co2+ and Ni2+, with the strongest phenotype being observed in the presence of zinc. Using the ypk9Δ mutant, we developed a high-throughput growth rescue screen based on the Zn2+ sensitivity phenotype. Screening of two libraries of Food and Drug Administration-approved drugs identified 11 compounds that rescued growth. Subsequently, we generated a zebrafish model for ATP13A2 deficiency and found that both partial and complete loss of atp13a2 function led to increased sensitivity to Mn2+. Based on this phenotype, we confirmed two of the drugs found in the yeast screen to also exert a rescue effect in zebrafish—N-acetylcysteine, a potent antioxidant, and furaltadone, a nitrofuran antibiotic. This study further supports that combining the high-throughput screening capacity of yeast with rapid in vivo drug testing in zebrafish can represent an efficient drug repurposing strategy in the context of rare inherited disorders involving conserved genes. This work also deepens the understanding of the role of ATP13A2 in heavy metal detoxification and provides a new in vivo model for investigating ATP13A2 deficiency.
The Development of a Screening Tool to Identify and Classify Nonadherence in Inflammatory Bowel Disease
Authors: Zand Aria , Nguyen Audrey , Stokes Zack , van Deen Welmoed , Reynolds Courtney , Dimitrova Magdalena , Khandadash Ariela , Dvorsky Miriam , Sauk Jenny , Esrailian Eric , Hommes Daniel 
Published: September 2019

Abstract

Background
Medication nonadherence is a challenge in chronic disease management. Tools that can both determine adherence levels and analyze patient-specific reasons for nonadherence are lacking.

Methods
Our tool was developed using 23 patient-reported items and its predictive performance was compared with the most widely used instrument in the literature.

Results
One hundred thirty-three IBD patients were included, 44 (33%) were nonadherent and 89 (67%) were adherent. Our screening question, with 87% sensitivity and 64% specificity, was followed by a 9-item survey for patients qualified as nonadherent.

Conclusions
Quantifying reasons for nonadherence can lead to more effective and personalized interventions for nonadherent patients.
Antibody-mediated rejection 16 years post-cardiac transplantation: a case report of an uncommon late presentation in a middle-aged woman
Authors: Miller Charles , Arkun Knarik , DeNofrio David , Sabe Marwa 
Published: September 2019

Abstract

Background
Very late antibody-mediated rejection (AMR) in heart transplant patients (over 10 years post-transplant) is very rare. It is associated with high mortality, graft dysfunction, and fulminant coronary artery vasculopathy (CAV) and should remain in the differential for patients presenting with late graft dysfunction.

Case summary
A 57-year-old woman 16 years of post-heart transplant with a previously unremarkable post-transplant course including protocol driven biopsies showing no rejection and a recent unremarkable screening nuclear stress test presented to our institution with clinical heart failure. Echocardiogram revealed graft dysfunction and endomyocardial biopsy showed no signs of cellular rejection, but evidence of AMR. The patient was treated with steroid and immunotherapy with clinical improvement but suffered several infectious complications and renal dysfunction requiring haemodialysis related to her immunotherapy treatment. Despite aggressive AMR management, donor-specific antibodies and symptoms persisted and CAV progressed.

Discussion
This case illustrates the poor diagnostic yield of non-invasive testing for AMR, and highlights importance to clinicians of considering AMR even if the patient over 10 years post-transplant when the diagnosis is rare.
Acute fluctuating neurological deficits after pulmonary vein isolation: unmasking a rare complication due to spontaneous spinal subdural bleeding: a case report
Authors: Cioffi Giacomo Maria , Regoli François , Conte Giulio , Auricchio Angelo 
Published: September 2019

Abstract

Background
Pulmonary vein isolation (PVI) is becoming the therapy of choice for symptomatic paroxysmal drug-refractory atrial fibrillation (AF). The most frequently reported complications are vascular complications (1.4%). Bleeding complications of the central nervous system have rarely been described. We report a case of spontaneous spinal bleed after PVI.

Case summary
A 68-year-old woman with a 2-year history of highly symptomatic paroxysmal AF (EHRA 3) was referred for a PVI redo procedure. A high-density mapping showed pulmonary vein reconnection of all pulmonary veins successfully isolated by radiofrequency ablation. During the entire procedure, the patient had sinus rhythm with an ACT around 300 s. No intraprocedural and peri-procedural complications occurred. Four hours after haemostasis, the anticoagulation clotting time (ACT) was 110 s and rivaroxaban (20 mg) was reinitiated. In the following hours, the patient developed fluctuating neurological lower limb symptoms. A lumbar magnetic resonance imaging showed a subdural spinal haematic collection with an associated epidural component from L3 to S2 exerting compression over the dural sheath. A conservative treatment approach was adopted with progressive recovery of sensorial and motor deficits. After 5 months, the patient still presented residual lower limb motor deficits necessitating the support of a walking stick.

Discussion
We describe the first case of a spontaneous spinal bleeding following PVI. Given the gradual diffusion of PVI to treat AF in more clinically complex patients with a larger range of comorbidities, particular consideration should be given to seek predisposing bleeding factors in order to assess the risk for neurological complications.
Percutaneous left atrial appendage closure in a patient with haemophilia and atrial fibrillation: a case report
Authors: Güray Ümit , Korkmaz Ahmet , Gürsoy Havva Tuğba , Elalmış Özgül Uçar 
Published: September 2019

Abstract

Background
Atrial fibrillation (AF) is the most common cardiac arrhythmia and is a major cause of embolic stroke. In patients with hereditary bleeding disorders such as haemophilia, management of AF particularly anticoagulation can be quite challenging. Left atrial appendage (LAA) closure is an emerging option in AF patients who are not eligible for oral anticoagulation therapy because of contraindications or high bleeding risk.

Case summary
A 67-year-old man with permanent AF and haemophilia was referred for further evaluation of our cardiology clinic by his primary haematologist. The CHA2DS2-VASc score was estimated to be 3 and the HAS-BLED score was 3. Due to high risk of bleeding, we decided to perform percutaneous LAA closure instead of oral anticoagulation. Pre-procedural cardiac computerized tomography angiography and transoesophageal echocardiography were performed for measurements of LAA dimensions and exclude LAA thrombus. Percutaneous LAA occlusion was performed using a 28-mm AmplatzerTM AmuletTM device. The final result was excellent without significant residual leak, pericardial effusion, and embolic complication. Clopidogrel 75 mg/day and aspirin 81 mg/day for 1 month with adequate FVIII prophylaxis and then only aspirin 81 mg/day for 2 months were recommended. No antiplatelet was given after 3 months. The patient did not report any thrombotic or haemorrhagic adverse events and there were no complications related to implanted device after 1 year of follow-up.

Discussion
In patients with hereditary bleeding disorders such as haemophilia, management of AF particularly anticoagulation can be quite challenging. In this report, we present a case of percutaneous LAA occlusion using AmplatzerTM AmuletTM device in a patient who has haemophilia and permanent AF. LAA closure has the potential to be more cost effective as compared to oral anticoagulation therapy due to lesser necessity of clotting factor infusion.