bluuebunny/crossref_metadata_2025_split huggingface dataset:
Self-compassion among social workers
Authors: Jay Miller J , Lee Jacquelyn , Shalash Nada , Poklembova Zuzana 
Published: February 2019

Summary In recent years, the practice of self-compassion has garnered increasing attention in the literature, yet little is known about self-compassion in the field of social work. The purpose of this cross-sectional exploratory study was to examine self-compassion among social workers (N = 1011) located in a state in the southeastern United States. Specifically, this study was guided by two distinct, yet interconnected research queries: (1) How self-compassionate are social workers and (2) what personal and professional factors contribute to self-compassion among social workers? Findings Findings suggest social workers are fairly self-compassionate. Significant group differences in self-compassion exist by perceived health status (self-report), relationship status, social work licensing, and professional organization affiliation. Significant predictors of self-compassion included health status, educational level, and relationship status (in descending order of predictive power). Applications Adept and ethical social work practice requires that practitioners engage in self-compassionate practices. This study offers pragmatic implications for social work practice, including training and apposite areas for research.
Changes in advanced glycation end products, beta-defensin-3, and interleukin-17 during diabetic periodontitis development in rhesus monkeys
Authors: Jiang Hui , Li Yuanmin , Ye Changchang , Wu Wanhong , Liao Guangneng , Lu Yanrong , Huang Ping 
Published: February 2019

The bidirectional relationship between diabetes mellitus (DM) and periodontal disease has drawn great attention; however, the mechanisms underlying their association remain unclear. In this study, we aimed to develop a rhesus monkey model of diabetic periodontitis and explore the potential mechanisms by which DM affects the progression of periodontal disease. Three healthy rhesus monkeys were selected as the control group. Five streptozotocin-induced diabetic rhesus monkeys were chosen as the experimental group. Ligature placement was used to induce periodontitis. The changes in the levels of advanced glycation end products (AGEs), beta-defensin-3 (BD-3), and interleukin-17 (IL-17) were measured using enzyme-linked immunosorbent assays (ELISA) and real-time reverse transcription polymerase chain reaction (RT-PCR) at different stages during disease progression. Periodontitis was confirmed by clinical assessment, radiographic images, and histological examination. Significant changes in the levels of AGEs and BD-3 in serum were observed at the periodontitis stage in diabetic rhesus monkeys ( P < 0.05). The expression of BD-3 mRNA in the gingiva of diabetic group at baseline was significantly high ( P < 0.05). Diabetic monkeys exhibited significantly enhanced IL-17 mRNA expression at the periodontitis stage ( P < 0.05). Our findings indicated that the rhesus monkey can serve as an ideal model for exploring the pathogenesis of diabetic periodontitis, and the hyperglycemic environment may accelerate inflammatory response and weaken the defense system in periodontal tissues.Impact statementThe mechanism underlying the association between diabetes mellitus (DM) and periodontal disease is not yet fully understood. Hence, there is a need to establish animal models to reveal the effect of DM on the pathogenesis of periodontitis. In this study, we explored the appropriate methods for inducing periodontitis and shortening the modeling time in rhesus monkeys, to investigate the pathogenesis of diabetic periodontitis and develop innovative therapies. Our results suggest that a hyperglycemic environment might lead to the destruction of periodontal tissues by accelerating inflammatory response and weakening the defense system in periodontal tissues. Therefore, this study has significant treatment implications regarding the regulation of the immune response against periodontal diseases in patients with DM.
A review of the impact of utilising electronic medical records for clinical research recruitment
Authors: Lai Yan See , Afseth Janyne Dawn 
Published: February 2019

Introduction: Recruitment is an important aspect of clinical research, as poor recruitment could undermine the scientific value of a trial or delay the development process of new treatments. The development of electronic medical records provides a new way to identify potential participants for trials by matching the eligibility criteria with patients’ data within electronic medical records. Methods: A literature search was performed to examine the effectiveness and efficiency of the electronic medical record recruitment method using MEDLINE, PubMed, PubMed Central, CINAHL Plus with Full Text, ScienceDirect and Cochrane Library databases. These searches generated 11 articles that met the eligibility criteria, and handsearching reference lists generated two additional articles bringing the total number of articles to 13. These articles were subjected to critical appraisal utilising the Effective Public Health Practice Project tool. Results: Out of the 13 included articles, 11 provided quantitative data on recruitment effectiveness while seven articles provided quantitative data on recruitment efficiency. The automation in screening and patient identification by using alerts, a notification system, to notify research staff of a potential participant, was observed to contribute to higher recruitment yield and reduced workload due to its specificity on participant screening. The use of electronic medical record alerts was found to be associated with better recruitment outcomes when they were sent to dedicated research staff rather than physicians. Using electronic medical records for recruitment was found to be effective due to its capability for patient identification outside working hours and fast processing time, which was particularly useful for clinical trials in acute conditions. Several challenges may hinder the impact of the electronic medical record recruitment method, including the lack of conformity of clinical trial eligibility criteria and electronic medical record data structure and missing data. ‘Alert fatigue’ could also impact on the effectiveness of this method in the long term. Conclusion: The results from this review supports electronic medical record being an effective and efficient method for clinical trial recruitment. Recommendations were made in order to maximise the potential of the electronic medical record recruitment method and also for future research in order to improve the quality of evidence to support this strategy for recruitment.
Variation of High-Sensitivity Troponin T Results in Patients Undergoing Continuous Renal Replacement Therapy
Authors: Srinivasan Sridhar Vikas , Chen Michael , Gerson Howard , MacNamara Elizabeth , Nessim Sharon J. 
Published: February 2019

Background: Cardiac troponins are the preferred biomarker to diagnose myocardial injury. Complicating the interpretation of serial troponins in patients with end-stage renal disease, it has been shown that the hemodialysis procedure results in a small but significant decline in high-sensitivity cardiac troponins (hs-cTnT). This raises the possibility that continuous renal replacement therapy (CRRT) might similarly alter cardiac troponin levels and affect their interpretation when cardiac ischemia is being considered. Objective: We sought to determine the effect of CRRT on hs-cTnT levels over time in a group of patients without active myocardial injury. Design: Prospective, observational study Setting: Single tertiary care hospital, Montreal, Quebec Patients: Ten critically ill patients with acute kidney injury (AKI) undergoing CRRT. Cardiac ICU (intensive care unit) patients and acute coronary syndrome patients were excluded from the study. The CRRT prescription was at the discretion of the treating intensivist and relatively high doses were used in this study. Measurements: The hs-cTnT levels were drawn pre-CRRT, within 6 hours of initiation, and approximately every 6 hours thereafter along with routine CRRT blood work. Methods: Changes in hs-cTnT, creatinine, and albumin levels were recorded over the course of CRRT. Mean change in serum analyte concentration and 95% confidence interval was determined for specified time intervals relative to baseline, with paired t tests used to determine statistical significance. Results: Among the 10 patients included in the study, the cause of AKI was primarily acute tubular necrosis from septic shock or hemorrhagic shock. Compared with baseline hs-cTnT levels prior to CRRT initiation, mean hs-cTnT level fell by 42% at 5 to 10 hours post-CRRT initiation, followed by a plateauing of levels for the duration of time on CRRT. Limitations: Single-center study only applicable to hs-cTnT assay. Conclusions: This study demonstrates a significant decrease in hs-cTnT within 5 to 10 hours of CRRT initiation. This suggests that interpretation of cardiac troponin changes during CRRT must take into consideration the timing of dialysis initiation relative to the time of sample collection.
The Safety Profile of Percutaneous Minimally Invasive Sacroiliac Joint Fusion
Authors: Shamrock Alan Gregory , Patel Anand , Alam Milad , Shamrock Keith Hayden , Al Maaieh Motasem 
Published: February 2019

Study Design: Literature review. Objectives: Systematic review of the existing literature to determine the safety of minimally invasive (MI) sacroiliac (SI) joint fusion through the determination of the rate of procedural and device-related intraoperative and postoperative complications. Methods: All original studies with reported complication rates were included for analysis. Complications were defined as procedural if secondary to the MI surgery and device related if caused by placement of the implant. Complication rates are reported using descriptive statistics. Random-effects meta-analysis was performed for preoperative and postoperative Visual Analog Score (VAS) pain ratings and Oswestry Disability Index (ODI) scores. Results: Fourteen studies of 720 patients (499 females/221 males) with a mean follow-up of 22 months were included. Ninety-nine patients (13.75%) underwent bilateral SI joint arthrodesis resulting in a total of 819 SI joints fused. There were 91 reported procedural-related complications (11.11%) with the most common adverse event being surgical wound infection/drainage (n = 17). Twenty-five adverse events were attributed to be secondary to placement of the implant (3.05%) with nerve root impingement (n = 13) being the most common. The revision rate was 2.56%. MI SI joint fusion reduced VAS scores from 82.42 (95% confidence interval [CI] 79.34-85.51) to 29.03 (95% CI 25.05-33.01) and ODI scores from 57.44 (95% CI 54.73-60.14) to 29.42 (95% CI 20.62-38.21). Conclusions: MI SI joint fusion is a relatively safe procedure but is not without certain risks. Further work must be done to optimize the procedure’s complication profile. Possible areas of improvement include preoperative patient optimization, operative technique, and use of intraoperative real-time imaging.
Biomechanical and Functional Outcomes After Medial Patellofemoral Ligament Reconstruction: A Pilot Study
Authors: Shams Kameron , DiCesare Christopher A. , Grawe Brian M. , Wall Eric , Parikh Shital N. , Galloway Marc , Kitchen Katie , Foss Kim Barber , Thomas Staci M. , Montalvo Alicia M. , Colosimo Angelo J. , Myer Gregory D. 
Published: February 2019

Background: Previous studies have acknowledged the medial patellofemoral ligament (MPFL) as the primary stabilizer of the patella, preventing lateral displacement. MPFL reconstruction (MPFL-R) restores stability and functionality to the patellofemoral joint and has emerged as a preferred treatment option for recurrent lateral patellar instability. Purpose: To objectively measure biomechanical characteristics of athletes cleared for return to sport after MPFL-R compared with healthy controls. Study Design: Cohort study; Level of evidence, 3. Methods: A prospective case-control study design was employed on 31 total athletes. Sixteen athletes (6 male, 10 female; mean age, 16.1 ± 2.74 years; 385 ± 189 days after surgery and 235 ± 157 days after return to sport) underwent MPFL-R and were medically cleared to return to sport. This group was matched by age, sex, and activity level to 15 healthy athletes with no history of lower extremity injuries. Athletes and controls completed validated questionnaires as well as hopping, jumping, and cutting tests with 3-dimensional motion analysis and underwent strength, flexibility, laxity, and balance assessments. Results: Participants in the MPFL-R group scored significantly lower (worse) on the International Knee Documentation Committee (IKDC) (89.2 ± 7.6 vs 98.1 ± 2.0, respectively; P = .0005) and significantly higher (worse) on the Tampa Scale for Kinesiophobia (TSK) (32.4 ± 5.0 vs 25.4 ± 6.5, respectively; P = .006) than those in the control group, but there was no difference in the Kujala score (95.6 ± 5.3 vs 98.8 ± 3.0, respectively; P = .06). Participants in the MPFL-R group demonstrated reduced hip and ankle flexion relative to those in the control group ( P < .05). Participants in the MPFL-R group also took significantly longer to complete the 6-m timed hop test relative to those in the control group ( P < .05). No statistically significant differences were found in anthropometrics, knee extension or flexion strength, hamstring flexibility, hip abduction strength, or joint laxity between the MPFL-R and control groups. Conclusion: The current data indicate that MPFL-R generally restores functional symmetry, while subtle deficits in global power may remain after being released to full activity. Clinicians should ensure that athletes are fully rehabilitated before returning to sport after MPFL-R by emphasizing functional multijoint exercises.
Iron catalyst supported on modified kaolin for catalytic wet peroxide oxidation
Authors: Boukhemkhem Ali , Rida Kamel , Pizarro Alejandro H. , Molina Carmen B. , Rodriguez Juan J. 
Published: February 2019

AbstractAn iron catalyst supported on the modified Tamazert kaolin has been prepared and tested in catalytic wet peroxide oxidation using phenol and 4-chlorophenol (4-CP) as target compounds (100 mg/L initial concentration). Kaolin is not usually employed as a catalytic support due to its low developed porous structure, but its textural properties may be improved upon calcination and acid and basic treatment. The catalyst was characterized by N2 adsorption–desorption and chemical analysis by total-reflection X-ray fluorescence spectroscopy. The catalytic tests were carried out in a batch reactor with a stoichiometric amount of H2O2. The catalytic efficiency was studied within the temperature range of 25–55°C at an initial pH of 3.3 and 1 g/L catalyst. Complete phenol and 4-CP removal was achieved with no significant differences in phenol and 4-CP conversions within the temperature range tested. Meanwhile, total organic carbon (TOC) reduction was greatly favoured by increasing the temperature, which may be partially attributed to a probable contribution of a homogeneous reaction associated with iron leaching. However, this effect might be of limited significance because the highest concentrations of iron in the liquid phase were below 4.5 and 8.5 mg/L in the experiments with phenol and 4-CP, respectively. At 55°C, TOC was reduced by ~70% after 4 h reaction time, with the remaining by-products corresponding almost completely to low-molecular-weight carboxylic acids of very low ecotoxicity.
Cognitive performance and functional outcomes of carriers of pathogenic copy number variants: analysis of the UK Biobank
Authors: Kendall Kimberley M. , Bracher-Smith Matthew , Fitzpatrick Harry , Lynham Amy , Rees Elliott , Escott-Price Valentina , Owen Michael J. , O'Donovan Michael C. , Walters James T.R. , Kirov George 
Published: February 2019

BackgroundRare copy number variants (CNVs) are associated with risk of neurodevelopmental disorders characterised by varying degrees of cognitive impairment, including schizophrenia, autism spectrum disorder and intellectual disability. However, the effects of many individual CNVs in carriers without neurodevelopmental disorders are not yet fully understood, and little is known about the effects of reciprocal copy number changes of known pathogenic loci.AimsWe aimed to analyse the effect of CNV carrier status on cognitive performance and measures of occupational and social outcomes in unaffected individuals from the UK Biobank.MethodWe called CNVs in the full UK Biobank sample and analysed data from 420 247 individuals who passed CNV quality control, reported White British or Irish ancestry and were not diagnosed with neurodevelopmental disorders. We analysed 33 pathogenic CNVs, including their reciprocal deletions/duplications, for association with seven cognitive tests and four general measures of functioning: academic qualifications, occupation, household income and Townsend Deprivation Index.ResultsMost CNVs (24 out of 33) were associated with reduced performance on at least one cognitive test or measure of functioning. The changes on the cognitive tests were modest (average reduction of 0.13 s.d.) but varied markedly between CNVs. All 12 schizophrenia-associated CNVs were associated with significant impairments on measures of functioning.ConclusionsCNVs implicated in neurodevelopmental disorders, including schizophrenia, are associated with cognitive deficits, even among unaffected individuals. These deficits may be subtle but CNV carriers have significant disadvantages in educational attainment and ability to earn income in adult life.Declaration of interestNone.
Hall–Petch Relationship in Aluminum and Aluminum Alloys
Authors: Armstrong Ronald W. 
Published: February 2019

The mechanical properties of aluminum are shown to be of special importance beginning from the early 20th-century production of the material in single crystal and polycrystalline form. Experimental and theoretical researches of the time were concerned with particular influence of polycrystalline microstructure and the presence of crystal (grain) boundaries on both the material strength properties and on relation of those same properties to those for the full range of metal and alloy structures. Now it is well established that a relatively low value of the microstructural stress intensity, kε, is obtained for aluminum in the generalized Hall–Petch relation for its stress–strain, σε − ε, behavior depending on the average grain diameter, l, with intercept (friction) stress, σ0ε, which relation is given as:
id="unequ63_1">σε=σ0ε+kεl−1/2With hindsight, taking σε = σ0ε provided the first connection between single crystal and polycrystalline strength measurements in the pioneering Taylor theory of plasticity proposed for aluminum and other face-centered cubic metals. Later, conventional and ultrafine grain size measurements are shown to verify the fuller H–P dependence. The present account builds onto the early history. A description is given for temperature, strain rate, and alloy-dependent mechanical property measurements. An understanding of the total measurements is described in terms of a dislocation pile-up model description for the relation. Emphasis is given to kε for pure aluminum and related metals being determined by cross-slip forced at grain boundaries. Particular attention is given to two characteristics of the metal mechanical behavior: (1) very high rate loading deformations leading to shock and shock-less isentropic compression experiments and (2) important grain size influences on nanopolycrystalline material behaviors. Additional results are presented on H–P aspects of the material strain ageing, shear banding, ductile fracturing, and fatigue behaviors.
Effectiveness of Magnesium in Preventing Shivering in Surgical Patients: A Systematic Review and Meta-analysis
Authors: Kawakami Hiromasa , Nakajima Daisuke , Mihara Takahiro , Sato Hitoshi , Goto Takahisa 
Published: February 2019

BACKGROUND:
Clinical trials regarding the antishivering effect of perioperative magnesium have produced inconsistent results. We conducted a systematic review and meta-analysis with Trial Sequential Analysis to evaluate the effect of perioperative magnesium on prevention of shivering.

METHODS:
We searched PubMed, EMBASE, Web of Science, Cochrane Central Register of Controlled Trials, and 2 registry sites for randomized clinical trials that compared the administration of magnesium to a placebo or no treatment in patients undergoing surgeries. The primary outcome of this meta-analysis was the incidence of shivering. The incidence of shivering was combined as a risk ratio with 95% CI using a random-effect model. The effect of the route of administration was evaluated in a subgroup analysis, and Trial Sequential Analysis with a risk of type 1 error of 5% and power of 90% was performed. The quality of each included trial was evaluated, and the quality of evidence was assessed using the Grading of Recommendation Assessment, Development, and Evaluation approach. We also assessed adverse events.

RESULTS:
Sixty-four trials and 4303 patients (2300 and 2003 patients in magnesium and control groups, respectively) were included. The overall incidence of shivering was 9.9% in the magnesium group and 23.0% in the control group (risk ratio, 0.42; 95% CI, 0.33–0.52). Subgroup analysis revealed that the incidence of shivering was lower with IV (risk ratio, 0.29; 95% CI, 0.29–0.54; Grading of Recommendation Assessment, Development, and Evaluation, moderate), epidural (risk ratio, 0.24; 95% CI, 0.13–0.43; Grading of Recommendation Assessment, Development, and Evaluation, low), and intrathecal administration (risk ratio, 0.64; 95% CI, 0.43–0.96; Grading of Recommendation Assessment, Development, and Evaluation, moderate). Only trials with low risk of bias were included for Trial Sequential Analysis. The Z-cumulative curve for IV magnesium crossed the Trial Sequential Analysis monitoring boundary for benefit even though only 34.9% of the target sample size had been reached. The Z-cumulative curve for epidural or intrathecal administration did not cross the Trial Sequential Analysis monitoring boundary for benefit. No increase in adverse events was reported.

CONCLUSIONS:
Perioperative IV administration of magnesium effectively reduced shivering and Trial Sequential Analysis suggested that no more trials are required to confirm that IV magnesium effectively reduces shivering.
Trans-splicing of the C. elegans let-7 primary transcript developmentally regulates let-7 microRNA biogenesis and let-7 family microRNA activity
Authors: Nelson Charles , Ambros Victor 
Published: February 2019

ABSTRACT
The sequence and roles in developmental progression of the microRNA let-7 are conserved. In general, transcription of the let-7 primary transcript (pri-let-7) occurs early in development, whereas processing of the mature let-7 microRNA arises during cellular differentiation. In Caenorhabditis elegans and other animals, the RNA-binding protein LIN-28 post-transcriptionally inhibits let-7 biogenesis at early developmental stages, but the mechanisms by which LIN-28 does this are not fully understood. Nor is it understood how the developmental regulation of let-7 might influence the expression or activities of other microRNAs of the same seed family. Here, we show that pri-let-7 is trans-spliced to the SL1 splice leader downstream of the let-7 precursor stem-loop, which produces a short polyadenylated downstream mRNA, and that this trans-splicing event negatively impacts the biogenesis of mature let-7 microRNA in cis. Moreover, this trans-spliced mRNA contains sequences that are complementary to multiple members of the let-7 seed family (let-7fam) and negatively regulates let-7fam function in trans. Thus, this study provides evidence for a mechanism by which splicing of a microRNA primary transcript can negatively regulate said microRNA in cis as well as other microRNAs in trans.