bluuebunny/crossref_metadata_2025_split huggingface dataset:
The effect of dietary corn oil and fish oil supplementation in dogs with naturally occurring gingivitis
Authors: Lourenço Ana L. , Booij‐Vrieling Henriette E. , Vossebeld Carmen B. , Neves António , Viegas Carlos , Corbee Ronald J. 
Published: June 2018

AbstractThe aim of this randomized, double‐blinded, placebo‐controlled study was to evaluate if downregulation of the inflammatory response due to ingestion of high levels of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) can slow down gingivitis development, and thus delay the progression of periodontal disease (PD) in dogs. To this aim, 44 client‐owned adult dogs (>1 and <8 years old) with naturally occurring PD (stages 1 and 2) were submitted to a plaque, gingivitis and calculus scoring followed by a dental cleaning procedure and collection of blood samples. The animals were then fed a canine adult maintenance diet, supplemented with either corn oil (0.00 g EPA and 0.00 g DHA) or fish oil (1.53 g EPA and 0.86 g DHA, both per 1,000 kcal ME) over the following 5 months. At the end of this period, the PD scoring and the blood sampling were repeated. The animals consuming fish oil had higher plasma levels of the longer chain (C ≥ 20) omega 3 fatty acids (p < 0.01) and similar plasma levels of alpha‐linolenic acid (p = 0.53), omega 6 fatty acids (p > 0.63) and C reactive protein (p = 0.28) then the ones consuming corn oil. There were no differences between fish oil and corn oil diet supplementation on plaque (18.2 vs. 17.8,p = 0.78), calculus (10.1 vs. 11.5,p = 0.18) or gingivitis (19.3 vs. 19.0,p = 0.77) indexes. The authors conclude that supplementation with EPA + DHA does not slow down progression of PD in dogs.
Loss of specificity variants of WzxC suggest that substrate recognition is coupled with transporter opening in MOP‐family flippases
Authors: Sham Lok‐To , Zheng Sanduo , Yakhnina Anastasiya A , Kruse Andrew C , Bernhardt Thomas G 
Published: June 2018

SummaryBacteria produce a variety of surface‐exposed polysaccharides important for cell integrity, biofilm formation and evasion of the host immune response. Synthesis of these polymers often involves the assembly of monomer oligosaccharide units on the lipid carrier undecaprenyl‐phosphate at the inner face of the cytoplasmic membrane. For many polymers, including cell wall peptidoglycan, the lipid‐linked precursors must be transported across the membrane by flippases to facilitate polymerization at the membrane surface. Flippase activity for this class of polysaccharides is most often attributed to MOP (Multidrug/Oligosaccharidyl‐lipid/Polysaccharide) family proteins. Little is known about how this ubiquitous class of transporters identifies and translocates its cognate precursor over the many different types of lipid‐linked oligosaccharides produced by a given bacterial cell. To investigate the specificity determinants of MOP proteins, we selected for variants of the WzxC flippase involved in Escherichia coli capsule (colanic acid) synthesis that can substitute for the essential MurJ MOP‐family protein and promote transport of cell wall peptidoglycan precursors. Variants with substitutions predicted to destabilize the inward‐open conformation of WzxC lost substrate specificity and supported both capsule and peptidoglycan synthesis. Our results thus suggest that specific substrate recognition by a MOP transporter normally destabilizes the inward‐open state, promoting transition to the outward‐open conformation and concomitant substrate translocation. Furthermore, the ability of WzxC variants to suppress MurJ inactivation provides strong support for the designation of MurJ as the flippase for peptidoglycan precursors, the identity of which has been controversial.
Pathogenesis of primordial odontogenic tumour based on tumourigenesis and odontogenesis
Authors: Mikami Toshinari , Bologna‐Molina Ronell , Mosqueda‐Taylor Adalberto , Ogawa Ikuko , Pereira‐Prado Vanesa , Fujiwara Naoki , Pires Fabio Ramoa , Carlos Roman , Takata Takashi , Takeda Yasunori 
Published: June 2018

AbstractObjectivePrimordial odontogenic tumour (POT) is a rare benign mixed epithelial and mesenchymal odontogenic tumour. POT is composed of dental papilla‐like tissue covered with cuboidal to columnar epithelium that resembles to inner and outer enamel epithelium of the enamel organ without dental hard tissue formation. The aim of this study was to examine pathogenesis of POT based on tumourigenesis and odontogenesis.Subjects and methodsSix cases of POT were submitted for study. DNA analysis and transcriptome analysis were performed by next‐generation sequencing. Expression of amelogenin, ameloblastin and dentin sialophosphoprotein (DSPP) was examined by immunohistochemistry.ResultsThere were no gene mutations detected in any of analysed 151 cancer‐ and 42 odontogenesis‐associated genes. Enamel protein‐coding genes of Amelx, Ambn and Enam, and dentin protein‐coding genes of Col1a1, Dspp, Nes and Dmp1 were expressed, whereas expression of dentinogenesis‐associated genes of Bglap, Ibsp and Nfic was negative or very weak suggesting inhibition of dentin formation in POT after odontoblast differentiation. Immunoreactivity of amelogenin, ameloblastin and DSPP was detected in POT.ConclusionsPathogenesis of POT is considered to be genetically different from other odontogenic tumours. It is suggested that inhibition of enamel and dentin formation in POT is due to defects in dentin formation process.
Surgical versus non‐surgical treatment of actinic cheilitis: A systematic review and meta‐analysis
Authors: Carvalho Marianne de Vasconcelos , de Moraes Sandra Lúcia Dantas , Lemos Cleidiel Aparecido Araujo , Santiago Júnior Joel Ferreira , Vasconcelos Belmiro Cavalcanti do Egito , Pellizzer Eduardo Piza 
Published: June 2018

AbstractObjectiveThe aim of this systematic review was to compare outcomes between surgical and non‐surgical treatment of actinic cheilitis (AC).Materials and MethodsA systematic review and meta‐analysis based on the Preferred Reporting Items for Systematic reviews and Meta‐Analyses guideline were performed. A search of PubMed/MEDLINE, Web of Science, and Cochrane Library databases was conducted. Articles were selected based on the inclusion criteria: randomized clinical trials, prospective/retrospective studies, and case series with at least 10 patients, with a minimum follow‐up period of 6 months. A weighted remission rate (RER) and recurrence rate (RR) with a 95% confidence interval was performed. Data analysis was performed using a comprehensive meta‐analysis software.ResultsA total of 283 ACs in 10 studies were included. About 2.5% surgically treated cases underwent malignant transformation. The weighted remission rate was higher for surgical (92.8%) compared to non‐surgical treatment (65.9%). The recurrence rate was lower for surgical (8.4%) compared to non‐surgical treatment (19.2%).ConclusionIn this systematic review, the surgical treatment was more favorable than non‐surgical for AC. Meanwhile, further studies are needed that should maximize methodological standardization and have greater rigor of the data collection process.
High seroprevalence of dengue virus indicates that dengue virus infections are frequent in central and eastern Sudan
Authors: Adam Awadalkareem , Schüttoff Tom , Reiche Sven , Jassoy Christian 
Published: June 2018

AbstractObjectivesTo determine the seroprevalence of dengue in central and eastern Sudan and the breadth of neutralising antibody responses.MethodsBlood was drawn from 483 patients with fever who visited outpatient clinics in Port Sudan, Red Sea state, in three towns in Kassala state and in El Obeid, North Kordofan, in December 2012 and January 2013. Sera were tested for dengue virus IgG and IgM by ELISA (Panbio) and sera without serologic evidence of acute infection (IgM negative) were used for the analysis of the seroprevalence. DENV neutralisation tests were performed to determine the specificity of the ELISA and to examine the degree of cross‐neutralisation of multiple DENV serotypes.ResultsSixty‐seven per cent (302 of 448) of the sera were dengue virus IgG‐positive. The seroprevalence in Port Sudan was 89% (106 of 119 sera), in Kassala 61% (128 of 209) and in North Kordofan 56.7% (68 of 120). Thirty‐one of 32 ELISA‐positive sera neutralised dengue viruses indicating that the ELISA was highly specific. The majority of the sera broadly neutralised all four dengue virus serotypes indicating multiple infections.ConclusionsThe majority of the population in central and eastern Sudan has been infected with dengue viruses, many people repeatedly. The high seroprevalence underscores the need for extended dengue surveillance in Sudan, broad disease awareness in medical institutions and in the population and diagnostic capacity building for severe dengue infections.
Socioeconomic status and cigarette expenditure among US households: results from 2010 to 2015 Consumer Expenditure Survey
Authors: Siahpush Mohammad , Farazi Paraskevi A , Maloney Shannon I , Dinkel Danae , Nguyen Minh N , Singh Gopal K 
Published: June 2018

ObjectivesTo examine (1) the association between household socioeconomic status (SES) and whether a household spends money on cigarettes and (2) socioeconomic variations in proportion of total household expenditure spent on cigarettes among smoking households.MethodsWe pooled data from six consecutive years, 2010–2015, of the Consumer Expenditure Interview Survey. The interviews involved a structured questionnaire about household income, demographics and expenditures including expenditure on cigarettes. Households that reported cigarette expenditure in the previous 3 months were distinguished as smoking households. SES indicators were household poverty status, education and occupation of the head of household. Logistic regression was used to assess the association of household smoking status with SES. Fractional logistic regression was used to assess the association of cigarette expenditure as a proportion of total household expenditure with SES. The analysis sample size was 39 218.ResultsThe probability of spending money on cigarettes was higher among lower SES households. Households in poverty compared with those above 300% of poverty threshold had 1.86 (95% CI 1.61 to 2.16), households headed by a person with less than high school education compared with those headed by a person with at least a bachelor’s degree had 3.37 (95% CI 2.92 to 3.89) and households headed by a blue-collar work compared with those headed by a person in a managerial occupation had 1.45 (95% CI 1.26 to 1.66) higher odds of spending money on cigarettes. Similarly, the proportion of total household expenditure spent on cigarettes was higher among lower SES smoking households.ConclusionLower SES households are more likely to spend money on cigarettes and spend a larger proportion of their total expenditure on cigarettes. We recommend strategies effective in reducing smoking among low SES smokers.
Schwannomatosis: a genetic and epidemiological study
Authors: Evans D Gareth , Bowers Naomi L , Tobi Simon , Hartley Claire , Wallace Andrew J , King Andrew T , Lloyd Simon K W , Rutherford Scott A , Hammerbeck-Ward Charlotte , Pathmanaban Omar N , Freeman Simon R , Ealing John , Kellett Mark , Laitt Roger , Thomas Owen , Halliday Dorothy , Ferner Rosalie , Taylor Amy , Duff Chris , Harkness Elaine F , Smith Miriam J 
Published: June 2018

ObjectivesSchwannomatosis is a dominantly inherited condition predisposing to schwannomas of mainly spinal and peripheral nerves with some diagnostic overlap with neurofibromatosis-2 (NF2), but the underlying epidemiology is poorly understood. We present the birth incidence and prevalence allowing for overlap with NF2.MethodsSchwannomatosis and NF2 cases were ascertained from the Manchester region of England (population=4.8 million) and from across the UK. Point prevalence and birth incidence were calculated from regional birth statistics. Genetic analysis was also performed on NF2, LZTR1 and SMARCB1 on blood and tumour DNA samples when available.ResultsRegional prevalence for schwannomatosis and NF2 were 1 in 126 315 and 50 500, respectively, with calculated birth incidences of 1 in 68 956 and 1 in 27 956. Mosaic NF2 causes a substantial overlap with schwannomatosis resulting in the misdiagnosis of at least 9% of schwannomatosis cases. LZTR1-associated schwannomatosis also causes a small number of cases that are misdiagnosed with NF2 (1%–2%), due to the occurrence of a unilateral vestibular schwannoma. Patients with schwannomatosis had lower numbers of non-vestibular cranial schwannomas, but more peripheral and spinal nerve schwannomas with pain as a predominant presenting symptom. Life expectancy was significantly better in schwannomatosis (mean age at death 76.9) compared with NF2 (mean age at death 66.2; p=0.004).ConclusionsWithin the highly ascertained North-West England population, schwannomatosis has less than half the birth incidence and prevalence of NF2.
Click reactions with functional sphingolipids
Authors: Fink Julian , Seibel Jürgen 
Published: June 2018

Abstract
Sphingolipids and glycosphingolipids can regulate cell recognition and signalling. Ceramide and sphingosine-1-phosphate are major players in the sphingolipid pathways and are involved in the initiation and regulation of signalling, apoptosis, stress responses and infection. Specific chemically synthesised sphingolipid derivatives containing small functionalities like azide or alkyne can mimic the biological properties of natural lipid species, which turns them into useful tools for the investigation of the highly complex sphingolipid metabolism by rapid and selective ‘click chemistry’ using sensitive tags like fluorophores. Subsequent analysis by various fluorescence microscopy techniques or mass spectrometry allows the identification and quantification of the corresponding sphingolipid metabolites as well as the research of associated enzymes. Here we present an overview of recent advances in the synthesis of ceramide and sphingosine analogues for bioorthogonal click reactions to study biosynthetic pathways and localization of sphingolipids for the development of novel therapeutics against lipid-dependent diseases.
On Georgian Preverbs
Authors: Makharoblidze Tamar 
Published: June 2018

Abstract
This paper describes the classification of the functions of preverbs in Georgian and the other Kartvelian languages as a contribution to the typology of this issue. Preverbs have different meanings and activities in different languages. The typological classification of the functions of preverbs reveals the four core functions: spatial, temporal, objective and lexical. This paper discusses verbal argument structure alternations encoded by preverbs. I argue that preverbs affect verbal valency changes and stimulate object role-shifting in Georgian verbs and other Kartvelian languages. I also argue that preverbs have a crucial role in object alternation across the languages.
Mixed Feelings: Attitudes towards English loanwords and their use in South Korea
Authors: Rüdiger Sofia 
Published: June 2018

Abstract
This questionnaire study investigates South Korean students’ attitudes towards English loanwords and their use. Even though English enjoys high prestige in Korean society and is considered a requirement for personal and professional advancement, usage of English loanwords is evaluated predominantly negatively or with mixed feelings. For loanwords that semantically deviate from standard English meanings and thus demonstrate Korean identity (i.e., Konglish loanwords), the evaluations turn even more to the negative. Nevertheless, participants also posit positive aspects of general English and Konglish loanword use and, additionally, put forward a variety of perceived reasons for using English words. This study shows that general positive attitudes related to a language can be reversed or at least modified when it comes to the combination of the prestigious language with the native language.
Juveniles with Sexual Behavior Problems: A Treatment Program Evaluation
Authors: Calvert James D. , Bauer Terri 
Published: June 2018

AbstractJuveniles commit a significant portion of the sexual abuse perpetrated on other children. Treatment for juveniles with sexual behavior problems has moved from modified adult treatments to more developmentally appropriate approaches. Although cognitive-behavioral therapy is the most commonly used approach, research indicates that inclusion of significant others in the juvenile’s life is important when working with these youth. The inclusion of the juvenile’s family is seen as especially vital in treatment success. The current article reviews treatment outcomes, as measured by recidivism (re-offense) rates, for juvenile males completing a county juvenile sex offender treatment program. The program emphasizes family involvement and collaboration with juvenile probation officers, correctional officer, attorneys, and judges in the ongoing treatment as well as support of the juvenile and his/her family. Results indicate a sexual recidivism rate of 7.2% which is consistent with meta-analyses of research on sexual recidivism in treatment programs. The recidivism rate for non-sexual crimes was 33.7%, which is lower than typically reported in meta-analyses of treatment outcomes. The treatment program was equally effective for all juveniles, regardless of race.
Portugal as <i>Nostos</i> Interrupted
Authors: Kark Christopher 
Published: June 2018

In the present article, I examine the role of prophecy in Gabriel Pereira de Castro’s Ulisseia (1636) and António de Sousa de Macedo’s Ulissipo (1640), two pre-Restoration epics that center on Odysseus as the mythological founder of Lisbon. In both epics, a prophecy drives the hero to found Lisbon as a precondition for making his nostos to Ithaka while also speaking of a fabled warrior landing at the future site of Lisbon in order to found a great empire. is prophecy echoes others that predict the return of the Encoberto, yet they also tempt Odysseus into forgetting his nostos for the sake of Lisbon’s foundation. Insofar as forgetting one’s nostos is associated with a deathlike state (lêthê) in epic poetry, the parallel between Odysseus and the Encoberto strongly suggests that the imperial enterprise itself is a hazard that leads the hero towards oblivion and death.
Mito e transfiguração em Órfãos do Eldorado, de Milton Hatoum
Authors: Rodrigues Cecília 
Published: June 2018

Drawing on João Loureiro’s characterization of the sfumato nature of Amazonian people, in which real and imaginary elements form a single experience, this paper analyzes the interconnection between myth and reality in Órfãos do Eldorado (2008), Milton Hatoum’s fourth novel. Understanding Amazonian culture to be imbued with impulses leading to both reason and enchantment, I argue that a transfiguration of the Eldorado myth occurs via its literary redefinition. This phenomenon emerges through dialogue with Constantine P. Cavafy’s poem, "Η Πόλις" 'The City.' Departing from the common portrayal of the Eldorado myth as a search for riches, Hatoum refashions it to represent a search for love.
Robotic Automation Process – The operating system for the digital enterprise
Authors: Anagnoste Sorin 
Published: June 2018

Abstract
Robotic Process Automation (RPA) is going into a “maturity market”. The main vendor providers surpassed USD 1 billion in evaluation and the research they are launching these days on the market will change again radically the business landscape. It can be seen already what is coming next to RPA: intelligent optical character recognition (IOCR), chat-bots, machine learning, big data analytics, cognitive platforms, anomaly detection, pattern analysis, voice recognition, data classification and many more. As a result the top vendors developed partnerships with the main leading artificial intelligence providers, such as: IBM Watson, Microsoft Artificial Intelligence, Microsoft Cognitive services, blockchain, Google etc. On the business part, the consulting companies who are implementing the RPA solution are moving from developing Proof-of-Concepts (POCs) and Pilots to helping clients with RAP global roll-outs and developing Centre of Excellences (CoE). As a result, the experiences gathered so far by the author on this kind of projects will be tackled also in this paper. In this article will we will present also some data related to automation for different business areas (eg. Accounts Payable, Accounts Receivable etc) and how an assessment can be done correctly in order to decide if a process can be automatized and, if yes, up to which extent (ie. percent). Moreover, through the case studies we will provide (1) how now the RPA is integrated with Artificial Intelligence and Cloud, (2) how can be scaled in order to face hypes, (3) how can interpret data and (4) what savings these technologies can bring to the organizations. All the aforementioned services made Robotics Process Automation a very powerful tool since a year ago when the author did the last research. A process that was mainly not recommended for automation or was partially automated can be now fully automated with more advantages, such as: money, non-FTE savings and fulfillment time.
Statistical and econometric analysis of the correlation between financial transactions and real economy
Authors: Apostu Simona-Andreea 
Published: June 2018

Abstract
The economic activity generates two types of flows: flows of goods and services and cash flows. These two types of flows generate two types of circuits in the economy, flows of goods and services generate the circuit corresponding to real economy and monetary flows (incomes and expenditures) generate the monetary - financial circuit. The monetary circuit is fundamentally determined by the level and structure of real economy. Comparing production revenue used for consumption with the amount of products and services produced and purchased, an average pricing is obtained. Unless the condition that the revenues generated in the economy are equal to production, it will lead to rising prices, i.e., inflation. Therefore, an adequate correlation between financial flows and real economy must be ensured. From this perspective, were analysed countries from European Union over time, using panel analysis.
The influence of the strategic financial policies on share valuation in an unstable economic environment
Authors: Curmei Cătălin-Valeriu , Dincă Lavinia Elena , Curmei-Semenescu Ileana Andreea 
Published: June 2018

Abstract
In an unstable environment, the investors become more aware of the importance of a good assessment of the risk implied by their investment. Therefore, much attention is given to the amount of information provided by the issuer, as well as to the signals it offers to investors. The financial literature emphasizes the role of the dividend policy in signaling the financial soundness of the companies. Our paper aims to verify if the dividend and financing policies of the companies have a role to play in the share valuation in an unstable economic environment and if their explanatory power differs with the phases of the economic cycle. The period 2006-2010 was chosen in order to test our model, as it corresponds to a period of the economic cycle similar to the present one, which may lead to similar behavior of the market participants. Moreover, the behavioral economics sustains the importance of the recent experiences in shaping actors’ responses in conditions perceived as similar. Our analysis is made on a worldwide database including 5391 companies listed in the most important market indices on 82 national capital markets. We chose to multiple linear regressions for successive yearly periods in order to put in evidence in a straight and unambiguous manner the influence of the dividend and financing policies on the share valuation. It puts in evidence that the dividend policy remains an important signal for the investors and it is taken into consideration even more seriously in unstable economic environment. Moreover, the financing policy is emphasized as important signal in investors’ eyes.