bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sense of Abundance is Associated with Momentary Positive and Negative Affect: An Experience Sampling Study of Trait Gratitude in Daily Life
Authors: Simons Marianne , Lataster Johan , Peeters Sanne , Reijnders Jennifer , Janssens Mayke , Jacobs Nele 
Published: September 2019

Abstract
Results are reported from a study examining the association between subdimensions of trait gratitude (appreciation of others, sense of abundance, and simple appreciation, SGRAT, Thomas and Watkins 2003) and daily life affective processing, in order to respond to the acknowledged need for further research on how trait gratitude may contribute to our well-being. Using experience sampling methodology actual momentary experiences of positive and negative affect were measured on 7 consecutive days in a sample of 106 respondents (63 women and 43 men, varying in age from 18 to 65 years). Multilevel regression analyses revealed that only sense of abundance was significantly associated with momentary experiences of positive affect (positive association) and negative affect (negative association) in daily life. Our findings add to the theoretical understanding of the underlying pathway of the association between trait gratitude and well-being and provide a practical starting point for gratitude interventions.
Elgin on understanding: How does it involve know-how, endorsement and factivity?
Authors: Gordon Emma C. 
Published: September 2019

AbstractIn Chapter 3 ofTrue Enough, Elgin (2017) outlines her view of objectual understanding, focusing largely on its non-factive nature and the extent to which a certain kind of know-how is required for the “grasping” component of understanding. I will explore four central issues that feature in this chapter, concentrating on (1) the role of know-how, (2) the concept of endorsement, (3) Elgin’s critique of the factivity constraint on understanding, and (4) how we might use aspects of Elgin’s framework to inform related debates on the norm of assertion.
Predicting Intentions from Motion: The Subject-Adversarial Adaptation Approach
Authors: Zunino Andrea , Cavazza Jacopo , Volpi Riccardo , Morerio Pietro , Cavallo Andrea , Becchio Cristina , Murino Vittorio 
Published: September 2019

AbstractThis paper aims at investigating the action prediction problem from a pure kinematic perspective. Specifically, we address the problem of recognizing future actions, indeed human intentions, underlying a same initial (and apparently unrelated) motor act. This study is inspired by neuroscientific findings asserting that motor acts at the very onset are embedding information about the intention with which are performed, even when different intentions originate from a same class of movements. To demonstrate this claim in computational and empirical terms, we designed an ad hoc experiment and built a new 3D and 2D dataset where, in both training and testing, we analyze a same class of grasping movements underlying different intentions. We investigate how much the intention discriminants generalize across subjects, discovering that each subject tends to affect the prediction by his/her own bias. Inspired by the domain adaptation problem, we propose to interpret each subject as a domain, leading to a novel subject adversarial paradigm. The proposed approach favorably copes with our new problem, boosting the considered baseline features encoding 2D and 3D information and which do not exploit the subject information.
A presmooth estimator of unbiased distributions with length-biased data
Authors: Heidari Reza , Fakoor Vahid , Shariati Ali 
Published: September 2019

AbstractIn this paper, we propose a presmooth product-limit estimator to draw statistical inference on the unbiased distribution function representing the population of interest. The strong consistency of the estimator proposed is investigated. The finite sample performance of the proposed estimator is evaluated using simulation studies. It is observed that the proposed estimator exhibits greater efficiency in comparison with the alternative method in de Uña-Álvarez (Test 11(1):109–125, 2002).
The Effect of the Cause of Delivery on Neonatal Outcomes in Early Preterm Deliveries
Authors: Yılmaz Baran Şafak , TÖrer Birgin , Kalaycı Hakan , Doğan Durdağ Gülşen 
Published: September 2019

AbstractThe aim of this study was to evaluate the effect of causes of delivery on short-term neonatal morbidities and mortality in EPD (< 34 gestational weeks). We retrospectively analysed the deliveries occurring between 23 + 0 and 33 + 6th gestational weeks at our tertiary center during 2014–2018. A total of 290 deliveries were evaluated, and 369 newborns [singletons (56.4%), twins (36.6%) and triplets (7.1%)] were included in the study. The causes of deliveries were defined as spontaneously preterm birth (n = 107, 29%), preterm premature rupture of membranes (PPROM) (n = 131, 35.5%) or iatrogenic preterm birth (n = 131, 35.5%). The rate of neonatal respiratory distress syndrome (RDS), patent ductus arteriosus, bronchopulmonary dysplasia (BPD), intraventricular haemorrhagia (IVH), necrotising enterocolitis, retinopathy of prematurity, neonatal resuscitation, sepsis and death were similar between groups. However; neonatal RDS, BPD, IVH and sepsis were found to be higher in cases with chorioamnionitis, which could be considered as subcategory of PPROM. Preterm deliveries have an adverse effect on perinatal outcomes. Also, such causes of labor might be related to varied neonatal morbidities. However, splitting to early preterm deliveries into subgroups, according to cause of delivery, did not provide further information to predict such complications except chorioamnionitis.
Response Surface Methodology for the Evaluation of Magnetite Partitioning Behavior in Polyethylene Glycol-Based Aqueous Biphasic System
Authors: Shahrokhi Behnia , Pirdashti Mohsen , Managhebi Mozhgan 
Published: September 2019

Abstract
Response surface methodology in the framework of central composite design has successfully applied to polyethylene glycol (PEG)-based aqueous two-phase system in order to evaluate its efficiency in extracting Fe from iron ores with respect to PEG molecular weight, PEG concentration and salt concentration factors. Furthermore, ANOVA and multiple regression analysis have provided a second-order polynomial equation that is highly capable of predicting the experimental results. The PEG molecular weight and weight percent of the salt in the feed had a major and minor effects on the iron ion partition coefficient, respectively.
Stone, Scissors, Paper: Thinking Through Things in Chinese History
Authors: Ko Dorothy 
Published: September 2019

AbstractWhat would Chinese history look like with things taking the center stage? Our present understanding of this history is animated primarily by literate people in pursuit of examination degrees and sons, and often filtered through such modern social science categories as culture, ethnicity, and gender. In this introduction, I put the set of five articles in the special issue in conversation with recent research to identify new analytic categories and research strategies that accord agency to things, remap the parameters of Chinese history, and ponder the new directions afforded by the study of material cultures.
Thermal and Electrical Characterization of Power Mosfet Module Using Coupled Field Analysis
Authors: Cheng H.-C. , Wu C.-H. , Lin S.-Y. 
Published: September 2019

ABSTRACTTemperature resulting from the joule heating power and the turn-on and turn-off dissipation of high-power, high-frequency applications is the root cause of their thermal instability, electrical performance degradation, and even thermal-fatigue failure. Thus, the study presents thermal and electrical characterizations of the power MOSFET module packaged in SOT-227 under natural convection and forced convection through three-dimensional (3D) thermal-electric (TE) coupled field analysis. In addition, the influences of some key parameters like electric loads, ambient conditions, thermal management considerations (heat sink, heat spreader) and operation conditions (duty cycle and switching frequency) on the power loss and thermal performance of the power module are addressed. The study starts from a suitable estimation of the power losses, where the conduction losses are calculated using the temperature- and gate-voltage-dependent on-state resistance and drain current through the device, and the switching losses are predicted based on the ideal switching waveforms of the power MOSFETs applied. The effectiveness of the theoretical predictions in terms of device’s power losses and temperatures is demonstrated through comparison with the results of circuit simulation and thermal experiment.
VIRTUOUS ACCOMPLICES IN INTERNATIONAL CRIMINAL LAW
Authors: Jackson Miles 
Published: September 2019

AbstractHumanitarian actors sometimes have to decide whether to render assistance in situations that put them at risk of liability for aiding and abetting under international criminal law. This is the problem of the virtuous accomplice—the idea that knowingly contributing to the wrongdoing of others might, exceptionally, be the right thing to do. This article explains why the problem arises and clarifies its scope, before turning to criminal law in England and Wales and Germany to assess potential solutions. It argues that the best approach is to accept a defence of necessity—of justified complicity—and shows that such an argument works in international criminal law.
The effect of spring grass availability and grazing rotation length on the production and quality of herbage and milk in early spring
Authors: Claffey A. , Delaby L. , Galvin N. , Boland T. M. , Egan M. 
Published: September 2019

AbstractThe importance of spring grass in the diet of early lactation dairy cows has been widely acknowledged. Numerous studies completed on a plot/paddock basis have identified methods of increasing herbage availability in spring, but little focus was placed on how this impacts animal production. The aim of the current study was to investigate the impact of opening farm cover (OFC; grass availability on farm at turnout in spring; 1036 (high), 748 (medium) and 544 (low) kg DM/ha) and spring rotation length (fast – 56 days and normal – 63 days) on animal performance in early lactation and herbage production and quality. Spring rotation length had little effect on animal performance, herbage variables or sward composition. High OFC increased pre-grazing herbage mass, allowing for increased daily herbage allowance (DHA) compared to medium and low OFC. There was a reduced proportion of leaf in the sward of the high OFC compared to the low OFC, resulting in lower organic matter digestibility. Despite the reduction in sward quality observed as a consequence of achieving high OFC in spring, the greater DHA available to animals increased milk production (+1.4 kg milk/cow/day). Additionally, animals grazing a medium or low OFC had a greater requirement for silage supplementation in spring (+1.3 kg DM/cow/day). The benefits of the higher DHA highlighted in the current study suggest that autumn grazing management must be adapted to increase herbage availability in spring. However, the benefits observed in milk production did not persist beyond the first grazing rotation.
The Primacy of Practice
Authors: Zalabardo José L. 
Published: September 2019

AbstractI argue that our procedures for determining whether ascriptions of a predicate represent things as being a certain way are ultimately pragmatic. Pragmatic procedures are not subject to validation by the referential procedure – determining whether there is a property playing the role of its referent. Predicates can represent even if we can't provide an independent identification of its referent. For these predicates, the speakers’ knowledge of how they represent objects as being would have to be construed in terms of the ascription practices they associate with the predicates. The same approach can be applied to semantic predicates, such as ‘is representational’ or ‘refers to’. They can be treated as representational even if we can't provide an independent identification of their referents. The availability of this position undermines accounts of the referents of semantic predicates in naturalistic terms.
Microscopic Assessment of Dead Cell Ratio in Cryopreserved Chicken Primordial Germ Cells
Authors: Svoradová Andrea , Makarevich Alexander , Vašíček Jaromír , Olexiková Lucia , Dragin Sasa , Chrenek Peter 
Published: September 2019

AbstractThis study aimed to compare three methods of cell death assessment [trypan blue exclusion (TBE), propidium iodide viability assay (PIVA), and transmission electron microscopy] to evaluate fresh and frozen–thawed chicken primordial germ cells (PGCs). For this study, chicken PGCs were collected from ROSS 908 and Oravka breed hens, cryopreserved-thawed according to the protocol, and submitted for different cell death assessments. We observed significant differences between TBE and PIVA techniques in the detectable proportion of dead cells in fresh (14.14 ± 1.27 versus 7.16 ± 1.02%, respectively) and frozen–thawed (44.00 ± 2.11 versus 33.33 ± 1.67%, respectively) samples of the Oravka breed. Moreover, significant differences (p &lt; 0.05) between TBE and PIVA techniques in the detectable proportion of dead cells in fresh (9.20 ± 0.60 versus 5.37 ± 0.51%) samples of ROSS 908 breed were recorded. Differences may be due to methodological, sensitivity, and toxicity features of each technique tested, where TB stains cell cytoplasm of dead cells and PI penetrates and intercalates into DNA of dead cells. Therefore, we suggest using a more precise and sensitive PIVA for viability evaluation of PGCs. Further research is needed to apply various fluorochromes for more detailed cell viability evaluation.
Repetitive negative thinking in daily life and functional connectivity among default mode, fronto-parietal, and salience networks
Authors: Lydon-Staley D. M. , Kuehner C. , Zamoscik V. , Huffziger S. , Kirsch P. , Bassett D. S. 
Published: September 2019

AbstractRepetitive negative thinking (RNT) is a maladaptive response to sadness and a transdiagnostic risk-factor. A critical challenge hampering attempts to promote more adaptive responses to sadness is that the between-person characteristics associated with the tendency for RNT remain uncharacterized. From the perspective of the impaired disengagement hypothesis, we examine between-person differences in blood-oxygen-level-dependent (BOLD) functional networks underlying cognitive conflict signaling, self-referential thought, and cognitive flexibility, and the association between sadness and RNT in daily life. We pair functional magnetic resonance imaging with ambulatory assessments deployed 10 times per day over 4 consecutive days measuring momentary sadness and RNT from 58 participants (40 female, mean age = 36.69 years; 29 remitted from a lifetime episode of Major Depression) in a multilevel model. We show that RNT increases following sadness for participants with higher than average between-network connectivity of the default mode network and the fronto-parietal network. We also show that RNT increases following increases in sadness for participants with lower than average between-network connectivity of the fronto-parietal network and the salience network. We also find that flexibility of the salience network’s pattern of connections with brain regions is protective against increases in RNT following sadness. Our findings highlight the importance of functional brain networks implicated in cognitive conflict signaling, self-referential thought, and cognitive flexibility for understanding maladaptive responses to sadness in daily life and provide support for the impaired disengagement hypothesis of RNT.
Epigenetic re-wiring of breast cancer by pharmacological targeting of C-terminal binding protein
Authors: Byun Jung S. , Park Samson , Yi Dae Ik , Shin Jee-Hye , Hernandez Sara Gil , Hewitt Stephen M. , Nicklaus Marc C. , Peach Megan L. , Guasch Laura , Tang Binwu , Wakefield Lalage M. , Yan Tingfen , Caban Ambar , Jones Alana , Kabbout Mohamed , Vohra Nasreen , Nápoles Anna María , Singhal Sandeep , Yancey Ryan , De Siervi Adriana , Gardner Kevin 
Published: September 2019

AbstractThe C-terminal binding protein (CtBP) is an NADH-dependent dimeric family of nuclear proteins that scaffold interactions between transcriptional regulators and chromatin-modifying complexes. Its association with poor survival in several cancers implicates CtBP as a promising target for pharmacological intervention. We employed computer-assisted drug design to search for CtBP inhibitors, using quantitative structure-activity relationship (QSAR) modeling and docking. Functional screening of these drugs identified 4 compounds with low toxicity and high water solubility. Micro molar concentrations of these CtBP inhibitors produces significant de-repression of epigenetically silenced pro-epithelial genes, preferentially in the triple-negative breast cancer cell line MDA-MB-231. This epigenetic reprogramming occurs through eviction of CtBP from gene promoters; disrupted recruitment of chromatin-modifying protein complexes containing LSD1, and HDAC1; and re-wiring of activating histone marks at targeted genes. In functional assays, CtBP inhibition disrupts CtBP dimerization, decreases cell migration, abolishes cellular invasion, and improves DNA repair. Combinatorial use of CtBP inhibitors with the LSD1 inhibitor pargyline has synergistic influence. Finally, integrated correlation of gene expression in breast cancer patients with nuclear levels of CtBP1 and LSD1, reveals new potential therapeutic vulnerabilities. These findings implicate a broad role for this class of compounds in strategies for epigenetically targeted therapeutic intervention.
The mechanism of the premetastatic niche facilitating colorectal cancer liver metastasis generated from myeloid-derived suppressor cells induced by the S1PR1–STAT3 signaling pathway
Authors: Lin Qi , Ren Li , Jian Mi , Xu Pingping , Li Jun , Zheng Peng , Feng Qingyang , Yang Liangliang , Ji Meilin , Wei Ye , Xu Jianmin 
Published: September 2019

AbstractThe tumor-derived factors involved in the expansion and accumulation of myeloid-derived suppressor cells (MDSCs) in metastatic dissemination of colorectal cancer (CRC) to the liver has not been studied. Immunohistochemistry was used to detect sphingosine-1-phosphate receptor 1 (S1PR1) and signal transducer and activator of transcription-3 (STAT3) in human colorectal tumors. IL-6 and interferon-γ were detected by enzyme-linked immunosorbent assay (ELISA). Tumor growth, invasion, and migration were evaluated by MTT, transwell, and wound healing assays, respectively. Subcutaneous tumor-bearing and CRC liver metastasis (CRLM) nude mouse models were constructed. The percentage of MDSCs was measured using multicolor flow cytometry. Western blot assay was used to evaluate S1PR1 and p-STAT3 expression in MDSCs after separation from the liver and tumor by magnetic antibody. T-cell suppression assay was detected by carboxyfluorescein succinimidyl ester (CFSE). Aberrant co-expressed S1PR1 and p-STAT3 was correlated with metachronous liver metastasis and poor prognosis in CRC. A mutual activation loop between S1PR1 and STAT3 can enhance CRC cell proliferation, migration, and invasion in vitro and in vivo. The expression of p-STAT3 and its downstream proteins can be regulated by S1PR1. p-STAT3 was the dependent signaling pathway of S1PR1 in the promotion of cell growth and liver metastasis in CRC. The level of IL-6 and the associated MDSCs stimulated by the S1PR1–STAT3 correlated with the number of liver metastatic nodes in the CRLM mouse models and patients. Increased CD14+HLA-DR−/low MDSCs from CRLM patients inhibited autologous T-cell proliferation and predict poor prognosis. The S1PR1–STAT3–IL-6–MDSCs axis operates in both tumor cells and MDSCs involved in the promotion of growth and liver metastasis in CRC. MDSCs induced by S1PR1–STAT3 in CRC cells formed the premetastatic niche in the liver can promote organ-specific metastasis.
Rethinking the ethical principles of genomic medicine services
Authors: Johnson Stephanie B. , Slade Ingrid , Giubilini Alberto , Graham Mackenzie 
Published: September 2019

Abstract
Clinical genome and exome sequencing is currently used in only a small fraction of patients, yet large scale genomic initiatives are becoming more embedded in clinical services. This paper examines the ethical principles that should guide regulatory processes regarding consent and data sharing in this context. We argue that a genomic dataset administered by the health system carries substantial societal benefits, and that the collective nature of this initiative means that at least those patients who benefit from genome sequencing have an ethical obligation to share their health information. This obligation is grounded in considerations of fairness. Furthermore, we argue that the use of genomic data for the advancement of medical knowledge should be permitted without explicit consent and that international and other bodies should be granted access to these data, provided certain conditions are satisfied.
The impact origin and evolution of Chryse Planitia on Mars revealed by buried craters
Authors: Pan Lu , Quantin-Nataf Cathy , Breton Sylvain , Michaut Chloé 
Published: September 2019

AbstractLarge impacts are one of the most important processes shaping a planet’s surface. On Mars, the early formation of the Martian crust and the lack of large impact basins (only four unambiguously identified: Hellas, Argyre, Utopia, and Isidis) indicates that a large part of early records of Mars’ impact history is missing. Here we show, in Chryse Planitia, the scarcity of buried impact craters in a near-circular area could be explained by a pre-existing topographic depression with more intense resurfacing. Spatially correlated with positive Bouguer anomaly, this near-circular region with a diameter of ~1090 km likely originated from an impact. This proposed large impact basin must have been quickly relaxed or buried after its formation more than 4.0 billion years ago and heavily modified by subsequent resurfacing events. We anticipate our study to open a new window to unravelling the buried records of early Martian bombardment record.
Admixture between old lineages facilitated contemporary ecological speciation in Lake Constance stickleback
Authors: Marques David A. , Lucek Kay , Sousa Vitor C. , Excoffier Laurent , Seehausen Ole 
Published: September 2019

AbstractEcological speciation can sometimes rapidly generate reproductively isolated populations coexisting in sympatry, but the origin of genetic variation permitting this is rarely known. We previously explored the genomics of very recent ecological speciation into lake and stream ecotypes in stickleback from Lake Constance. Here, we reconstruct the origin of alleles underlying ecological speciation by combining demographic modelling on genome-wide single nucleotide polymorphisms, phenotypic data and mitochondrial sequence data in the wider European biogeographical context. We find that parallel differentiation between lake and stream ecotypes across replicate lake-stream ecotones resulted from recent secondary contact and admixture between old East and West European lineages. Unexpectedly, West European alleles that introgressed across the hybrid zone at the western end of the lake, were recruited to genomic islands of differentiation between ecotypes at the eastern end of the lake. Our results highlight an overlooked outcome of secondary contact: ecological speciation facilitated by admixture variation.