bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reflective Tool on Advanced Access to Support Primary Healthcare Teams: Development and Validation of an Online Questionnaire
Authors: Gaboury Isabelle , Breton Mylaine , Beaulieu Christine , Renard Marianne , Sasseville Maxime , Maillet Lara , Hudon Catherine , Rodrigues Isabel , Malham Sabina Abou , Duhoux Arnaud , Haggerty Jeannie 
Published: November 2024

ABSTRACTRationaleAwareness of their standing relative to best practices motivates primary healthcare (PHC) teams to improve their practices. However, gathering the data necessary to create such a portrait is a challenge. An effective way to support the improvement of the practices of PHC teams is to simplify the availability of data portraying aspects of their practices that might need improvement. Timely access is one of the foremost challenges of PHC. Yet, very few tools supporting reflections on the implementation of best practices to improve access are available to PHC teams.Aims and ObjectivesTo develop an online reflective tool that evaluates the state of a PHC team member's advanced access practice and formulates customized recommendations for improvement.MethodsThis sequential multimethod study was informed by a literature review and an expert panel composed of researchers, patients, provincial and local decision‐makers, and PHC clinical and administrative staff in the province of Quebec, Canada. Consensus was reached on the content of the questionnaire and the prioritization of the recommendations.ResultsNo reflective tool on advanced access practices was found in the literature review. Grey literature was used to create an initial version of the questionnaire. This version was revised and enriched through consultation phases with the expert panel. Then, five iterations of the tool were tested with 169 PHC team members, which led to the conception of two distinct versions: one for clinical staff and one for administrative agents responsible for appointment booking. The final versions of the reflective tool are available online in both English and French.ConclusionThis reflective tool provides a portrait of PHC team members' advanced access practices as well as an automated report that contains personalized and prioritized recommendations for improvement. Further developments are necessary for its optimal use among PHC professionals other than physicians and nurse practitioners.
The effect of methylphenidate on the reproductive function of female rats
Authors: Cim Numan , Cim Bunyamin , Akyuz Cim Emine Fusun , Bulut Seval , Mammadov Renad , Suleyman Bahadır , Yucel Nurinisa , Mendil Ali Sefa , Coban Taha Abdulkadir , Suleyman Halis 
Published: November 2024

AbstractAimResearch on the effects of methylphenidate on female fertility is limited. This study evaluated the effects of methylphenidate on reproductive function, oxidants, antioxidants, proinflammatory cytokines, prolactin, and cortisol in female rats.MethodsForty‐eight albino Wistar female rats were divided into four groups consisting of 12 rats, which were given pure water orally once daily for 7 days (HG‐1), 10 mg/kg methylphenidate orally once daily for 7 days (MP‐1), pure water orally once daily for 30 days (HG‐2), and 10 mg/kg methylphenidate orally once daily for 30 days (MP‐2). At the end of the treatment periods, tail vein blood was collected from six rats per group for prolactin and cortisol determination. Subsequently, euthanasia was performed and the ovaries were removed. Ovaries were analyzed for malondialdehyde (MDA), total glutathione (tGSH), superoxide dismutase (SOD), catalase (CAT), interleukin‐1 beta (IL‐1β), and tumor necrosis factor‐alpha (TNF‐α), and immunohistochemically. For breeding, the remaining six rats were mated with male rats for 1 month. Rats that failed to give birth were classed as infertile.ResultsA comparison of MP‐1 and MP‐2 groups to healthy controls revealed an elevation in MDA and corticosterone levels, and a decline in tGSH, SOD, and CAT levels (p < 0.001). Methylphenidate did not affect prolactin, IL‐1β, and TNF‐α levels (p > 0.05). MP‐1 and MP‐2 exhibited immunopositivity for 8‐hydroxy‐2'‐deoxyguanosine (8‐OHDG). MP‐2 rats developed 66.7% infertility while MP‐1, HG‐1, and HG‐2 rats did not.ConclusionIn ovaries, methylphenidate caused oxidative stress, but did not induce inflammation. Long‐term use of methylphenidate caused increased cortisol levels and infertility.
Perceptions of service providers on available care for paediatric feeding disorder: A survey study
Authors: Brown Elizabeth , Forsingdal Shareen , Marshall Jeanne 
Published: November 2024

AimThis study aimed to describe current strengths and gaps in services for children with feeding needs in Southeast Queensland, Australia from the perspective of key professionals involved in service design and provision.MethodsA web‐based survey was distributed to health professionals involved in providing services to children with feeding needs, staff who triaged/managed referrals, and/or service team leaders in Southeast Queensland.ResultsThere were 79 responses to the survey, with 61 of these responses included in the analysis. Respondents identified several strengths in paediatric feeding disorder (PFD) service provision, particularly in the quality of care available for children who met service eligibility requirements. However, respondents also described services as disjointed, with limited coordinated multidisciplinary care available. Respondents frequently described service limitations relating to public service eligibility criteria, long waiting lists, and scant communication between services. Gaps were reported in the care available for children with ‘mild’ feeding difficulties and/or children who were not considered medically complex. Respondents also identified gaps in services secondary to a limited number of confident and trained professionals offering PFD care, particularly in the private sector.ConclusionsThis study described service providers' perceptions of available care for children with PFD in Southeast Queensland. Overall, the availability of PFD services appeared to be limited by eligibility criteria, service design, and staff capacity, suggesting that children with PFD are not receiving timely, multidisciplinary care in this geographical area. Further research into ideal service design is required to support preventative PFD care.
Impact of Collaborative Nursing Care on Health Outcomes of Mental Health Day Hospital Users: A Mixed Methods Study
Authors: Ventosa‐Ruiz Ana , Moreno‐Poyato Antonio R. , Cañete‐Massé Cristina , Rolduà‐Ros Júlia , Feria‐Raposo Isabel , Campoverde Karina , Puig Llobet Montserrat 
Published: November 2024

ABSTRACTIntroductionGiven that recovery‐oriented care focuses on empowering individuals with mental health challenges, collaborative care can be an effective tool for nurses in mental health day hospitals.AimTo deepen knowledge about the impact of collaborative nursing care for improving health outcomes of mental health day hospital users.MethodsA sequential and transformative mixed methods study was designed. In the first phase of this mixed methods study, quantitative data were collected from 144 users of mental health day hospitals. In phase two, a group of users underwent an intervention based on collaborative nursing care, through participatory action research, and qualitative data were collected. Finally, quantitative data were again collected from all users.ResultsThe users who participated in the intervention group improved quantitatively in terms of the quality of the therapeutic relationship. They also improved at different stages of the recovery process, thus the qualitative results confirmed that collaborative nursing care was an essential component in their recovery process.DiscussionThe findings highlight the critical role of collaborative nursing care in health outcomes. The therapeutic relationship was identified as a key factor in facilitating patient empowerment.ImplicationsThe study supports implementing collaborative nursing care models in mental health settings to enhance patient outcomes.Trial RegistrationClinicalTrials.gov identifier: NCT04814576
The lived experiences and unmet needs of prostate and colorectal male cancer survivors in rural Virginia: A qualitative study
Authors: Tariq Fariha , Lucas Alexander R. , Hill Sherrick , Philips Malik , Sheppard Vanessa B. 
Published: November 2024

AbstractBackgroundThe goal of this study was to gain an in‐depth understanding about the lived experiences and unmet needs of rural male cancer survivors.MethodsFocus groups were conducted with male survivors of prostate (N = 14) and colorectal cancers (N = 10), from rural Virginia. Demographic and clinical information were collected via surveys. A focus group guide contained questions about needs, lifestyles, and social networks of rural male cancer survivors. Focus group data were analyzed using Braun and Clarke's thematic analysis guidelines.ResultsFour primary themes emerged from the data: (1) contending with health problems, (2) quality and availability of health care services, (3) coping strategies to navigate survivorship, and (4) advocating for cancer prevention. Survivors had to contend with physical and emotional problems, which were a result of their cancer treatments. Due to their rural location, survivors had difficulty accessing health care services and had a limited understanding of the cancer‐related resources that existed in their counties. Family support, religiosity and acceptance served as important coping strategies. Many felt strongly about promoting cancer‐related education and awareness.ConclusionThe lived experiences and unmet needs of rural male cancer survivors comprised several challenges, which included health problems and lack of health care access. Coping mechanisms comprised reliance on familial bonds and religion. Findings from this study reveal the need for tailored interventions to target the health care, psychosocial, and informational needs of rural male cancer survivors.
Evolution and Impact of Hepatitis A Epidemiology in Europe—Systematic Literature Review of the Last 20 Years
Authors: Andani Anar , Mellou Kassiani , Dewda Pavitra , Eeuwijk Jennifer , Kassianos George , Van Damme Pierre , Steffen Robert 
Published: November 2024

ABSTRACTWhile globally hepatitis A (hepA) infections occur in 150 million people annually, European high‐income countries now have a low endemicity. However, this results in a more susceptible adult population which is prone to severe illness. To determine current epidemiological characteristics, we performed a systematic literature review to assess the severity of hepA disease in the past two decades in 11 European countries (i.e., Denmark, France, Germany, Greece, Hungary, Italy, the Netherlands, Spain, Sweden, Switzerland and the United Kingdom). Literature search was performed using PubMed and Embase between 1 January 2001 and 14 April 2021. Search terms included the disease (hepA), the 11 selected countries, the term ‘outbreaks’ and its synonyms, outcomes and terms for hepA virus circulation. In total, 43 records reported data on hepA disease outcomes. Hospitalisation rates varied between the countries, with annual rates exceeding 50% at least once in seven countries. The lowest hospitalisation rates were reported for the Netherlands (≤ 32%) and the highest for Greece (≥ 81%). Liver failure, haemorrhagic and other complications were rarely reported, and case fatality rates were low (0.03%–0.26%). Our findings are consistent with the trends observed globally. This systematic literature review highlights the need to increase awareness of hepA risks and to strengthen prevention strategies. Continuous monitoring of epidemiological data is crucial to assess which populations would most benefit from prevention, mainly with respect to future vaccination recommendations.
What does religion have to do with it: Exploring noninstitutional arguments for effective enforcement of IPR
Authors: Choudhary Latika , Daga Hardik 
Published: November 2024

AbstractThrough this paper the authors intend to establish a connect between religion and Intellectual Property Rights (IPR) particularly how various religions have justified IPRs and analyze whether religion can prove to be the much‐needed enforcement tool to fight infringement of IPRs. Intellectual Property is a domain which is governed purely by creativity and technology and has traditionally been justified by utilitarianism. However, the evidence we are in possession of does not entirely justify the rationale of exclusive rights granted under the current IPR regime. While questioning the contradictory evidence seems as a logical move, instead scholars are turning to nonindustrial faith‐based arguments which justify intellectual property as a moral end in itself. A growing number of academics are choosing to devote at least a portion of their research to examining how religious thought can influence approaches to difficult intellectual property questions because they find the religious texts to be a rich source of inspiration on both temporal and eternal issues. A major obstacle in the enforcement of IPR is that people are not entirely convinced that infringing IPR is unethical. This enforcement challenge, surprisingly in the presence of legislations, may be tackled by informal institutions such as religious commitments.
Noninvasive Monitoring of Steatotic Liver Disease in Western Diet‐Fed Obese Mice Using Automated Ultrasound and Shear Wave Elastography
Authors: Czernuszewicz Tomasz J. , Wang Yanhan , Jiang Lu , Kim Kenneth , Mikulski Zbigniew , Aji Adam M. , Rojas Juan D. , Gessner Ryan C. , Schnabl Bernd 
Published: November 2024

ABSTRACTBackground and AimsUltrasound imaging and shear wave elastography (SWE) can be used to noninvasively stage hepatopathologies and are widespread in clinical practice. These techniques have recently been adapted for small animal use in a novel 3D in vivo imaging system capable of high‐throughput automated scanning. Our goal was to evaluate the feasibility of using this imaging tool in the murine Western diet (WD) model, a highly translatable preclinical model of obesity, metabolic disease and liver fibrosis.MethodsFemale C57BL/6 mice (N = 48) were placed on WD or chow diet and imaged longitudinally for a period of 48 weeks. Imaging consisted of 3D B‐mode and targeted SWE captures. Liver volume, liver echogenicity and liver stiffness were quantified from in vivo imaging data. A subset of mice was sacrificed at various timepoints (0, 12, 24 and 48 weeks) for histological workup. Correlation analysis was performed between in vivo imaging and histological measurements to determine level of agreement.ResultsNoninvasive imaging showed statistically significant increases in liver volume and echogenicity, but non‐significant increase in liver stiffness in the WD‐fed cohort, suggesting development of hepatomegaly and steatosis, but negligible fibrosis. Ex vivo analysis confirmed significant increases in liver weight, liver triglycerides and ALT, but limited increases in fibrosis corroborating noninvasive imaging results. Correlation analysis between imaging and histology demonstrated good agreement between liver volume/liver weight (R2 = 0.85) and echogenicity/triglycerides (R2 = 0.76).ConclusionsThis study demonstrated that noninvasive ultrasound liver assessments are feasible in the WD mouse model and closely reflect the underlying pathological state of the animal. Automated ultrasound can serve as a high‐throughput noninvasive screening method for preclinical liver disease research and drug development.
A multiplex qPCR followed by high‐resolution melting analysis for the detection of blood‐feeding sources in Culex sp. mosquitoes
Authors: Vilela Thamyris Sampaio , Senne Nathália Alves , Paulino Patrícia Gonzaga , Araújo Thamires Rezende , de Lima Pamella Pryscila de Alvarenga Bissoli Maciel , Gonçalves Natalia Pedra , Guedes‐Junior Daniel da Silva , Angelo Isabele da Costa , Massard Carlos Luiz , Peixoto Maristela Peckle , Santos Huarrisson Azevedo 
Published: November 2024

AbstractCulex species, such as Culex quinquefasciatus and Culex nigripalpus display a range of feeding habits and act as vectors for pathogens that can cause diseases in both humans and animals. Understanding their feeding habits is pivotal for enhancing disease prevention strategies. The present study introduces the application of two multiplex real‐time PCR (qPCR) followed by high‐resolution melting (HRM) as a cost‐effective and time‐efficient alternative. This investigation involved the development of two multiplex qPCR‐HRM: assay 1 detects human, dog and chicken, while assay 2 detects cat, cattle and horse in Culex sp. engorged female mosquitoes. The qPCR‐HRM reactions showed a detection limit of one copy of genomic DNA when performed as single and multiplex qPCR‐HRM. The reaction efficiencies were 97.96% for human, 100.60% for dog, 99.03% for chicken, 99.92% for feline, 99.18% for cattle and 97.68% for horse. The qPCR‐HRM method, employing multiplex 1 and 2, was applied to field‐collected mosquitoes and demonstrated the ability to detect DNA from multiple blood sources within a single sample. By analysing both multiplexes, it was possible to identify up to five distinct blood sources in Cx. quinquefasciatus and Cx. nigripalpus, and up to two sources in Culex coronatus. Sequencing corroborated the qPCR‐HRM results, confirming the presence of DNA from one to four different blood sources with 100% accuracy. The development of these molecular methods may contribute for identification of blood‐feeding patterns in mosquitoes. It contributes to studies on the dissemination and transmission of pathogens among various animals and humans, thereby bridging the gap between epidemiology and vector monitoring.
Meat and the future of sustainable diets—Challenges and opportunities
Authors: Spiro A. , Hill Z. , Stanner S. 
Published: November 2024

AbstractThe British Nutrition Foundation convened a roundtable event in January 2024 entitled ‘Meat and the Future of Sustainable Diets: Turning Challenges into Opportunities’, bringing together multi‐sector stakeholders to discuss the social, nutritional, public health and environmental aspects of meat consumption within a sustainable food system. Participants explored the challenge of the complexity of balancing nutrition and planetary goals, emphasising the need to navigate trade‐offs between various dimensions of sustainability. Whilst recognising the global nature of the issue, the roundtable primarily focussed on a UK perspective. The discussion highlighted the urgency of transforming the food system to achieve net zero, whilst ensuring broader environmental benefits, nutritional adequacy and dietary and health equity across all life stages. Concerns about poor dietary patterns, particularly among vulnerable groups were raised, with participants stressing the need for policies that promote healthy, sustainable and equitable diets without worsening inequalities. These policies should also enhance livelihoods and community wellbeing, foster resilience and support local economies.On the supply side, participants called for better data within the agri‐food system, particularly at the farm level. They advocated for a multidimensional, holistic approach that goes beyond greenhouse gas emissions to encompass wider environmental impacts and whole‐farm benefits, such as enhancing soil health, promoting biodiversity, improving water management, supporting nutrient cycling and boosting farm‐level resilience through diversified cropping systems.Roundtable participants acknowledged existing recommendations to reduce meat consumption for both environmental reasons, such as land use and greenhouse gas emissions, and health concerns, as evidence links red, particularly processed, meat consumption with increased colorectal cancer risk. Given the variation in meat consumption globally and even locally between individuals, the discussion explored the potential of targeted campaigns to reduce high meat intake, along with the role of public food procurement and the food industry in decreasing processed meat consumption. The consensus was that dietary changes must be framed within the context of a balanced diet and broader sustainability concerns. Despite some differing viewpoints on implementation, participants agreed that transitioning to healthier, more sustainable diets is a priority. Collaboration across the entire food chain, from farm to fork, with investment in innovation, robust data collection and research, alongside policy support, was emphasised as essential to achieving this goal.
Ultrastructural overlap between immunotactoid and cryoglobulin glomerulopathy: A case report
Authors: Hirsch Daniel , McIlroy Kirsten , Tsui Roxana , Krishnaswamy Mrudula , Roxburgh Sarah 
Published: November 2024

AbstractImmunotactoid glomerulopathy (ITG), a condition characterised by highly organised microtubules on electron microscopy, and cryoglobulin glomerulopathy (CG) are rare forms of kidney injury that may be encountered in patients with cryoglobulinaemia. It has been proposed these two entities are part of the same disease process following observed clinical and histological similarities.
Comparison of Suture Anchor Repair and Suture Tape Augmentation for Reconstruction of the Anterior Talofibular Ligament: A Biomechanical Study
Authors: Shao Qingfeng , Hu Dahai , Chen Xinru , Wang Huajun , Xiao Lei , Teng Qiang , Hong Jinsong , Hou Huige , Zheng Xiaofei 
Published: November 2024

ABSTRACTObjectivesCurrently, there are various surgical options for the treatment of lateral ankle sprains, and deciding which surgical option to use is a question worth considering. Furthermore, there is a relative scarcity of mechanical research comparing suture anchor repair (SAR) and suture tape augmentation (STA) internal brace for the repair of the anterior talofibular ligament (ATFL). Therefore, this study aimed to compare the efficacy of arthroscopically all‐inside ATFL SAR and STA for reconstruction to treat lateral ankle sprains through biomechanical testing.MethodsEighteen fresh‐frozen cadaver ankles were used for the study and divided into one of three groups: (1) intact ATFL group, (2) arthroscopically reconstructed with suture tape augmentation internal brace of the ATFL (STA group), and (3) arthroscopically repaired ATFL with suture anchors (SAR group). We used custom fixtures to test the specimens for loading to ultimate failure and stiffness.ResultsThe mean load to failure of the STA group (311.20 ± 52.56 N) was significantly higher than that of the intact ATFL group (157.37 ± 63.87 N; p = 0.0016) and the SAR group (165.27 ± 66.81 N; p = 0.0025). The mean stiffness of the STA group (30.10 ± 5.10 N/mm) was significantly higher than that of the intact ATFL (14.17 ± 6.35 N/mm; p = 0.0012) and the SAR group (15.15 ± 6.89 N/mm; p = 0.0021). The suture anchor repair withstood failure loads and stiffness similar to the intact ATFL.ConclusionsIn terms of failure load and stiffness, the reconstructive outcome of ATFL reconstruction with STA is markedly superior to that of SAR reconstruction of the ATFL and the intact ATFL. Additionally, the novel technique of the SAR was a reliable technique that offered biomechanical properties similar to intact ATFL.