bluuebunny/crossref_metadata_2025_split huggingface dataset:
Teacher Design Teams for School-Wide Curriculum Development: Reflections on an Early Study
Authors: Handelzalts Adam , Nieveen Nienke , Van den Akker Jan 
Published: September 2019

AbstractThis chapter reports and reflects upon an early study on the potential of teacher design teams as a means for school-wide curriculum development. To do so, the chapter provides the rationale behind teacher design teams together with experiences and findings from a school site where such teacher design teams were active in the redesign of their local curriculum. Here, teacher collaboration was seen as essential to bridge the gap between the work of individual teachers (within their own subjects and classrooms) and school-wide curriculum renewal aspirations. The chapter ends with discussion of several conclusions and recommendations for schools and teachers that aim to pursue such a teacher design team scenario.
Developing TPACK in Science and Mathematics Teacher Education in Tanzania: A Proof of Concept Study
Authors: Kafyulilo Ayoub , Fisser Petra 
Published: September 2019

AbstractSince 1997, the government of Tanzania has made several attempts at introducing technology into education. However, despite these efforts technology has not become integrated into educational practice. A main reason is that teachers do not embrace the use of technology in their teaching. This study was initiated to design, implement and evaluate a professional development arrangement aimed at promoting teachers’ use of technology in their teaching practice. The study started with a ‘proof of concept’ study. Based on experiences in Ghana and Kuwait, a professional development arrangement was developed that incorporated ‘learning technology by design’ to prepare pre-service science and math teachers for using technology in their teaching. The experiences from this study informed the design of a professional development arrangement for practicing science teachers. The iterative design, implementation and evaluation of the professional development arrangements will be presented and discussed.
Forest Fire Susceptibility Modeling Using a Convolutional Neural Network for Yunnan Province of China
Authors: Zhang Guoli , Wang Ming , Liu Kai 
Published: September 2019

Abstract
Forest fires have caused considerable losses to ecologies, societies, and economies worldwide. To minimize these losses and reduce forest fires, modeling and predicting the occurrence of forest fires are meaningful because they can support forest fire prevention and management. In recent years, the convolutional neural network (CNN) has become an important state-of-the-art deep learning algorithm, and its implementation has enriched many fields. Therefore, we proposed a spatial prediction model for forest fire susceptibility using a CNN. Past forest fire locations in Yunnan Province, China, from 2002 to 2010, and a set of 14 forest fire influencing factors were mapped using a geographic information system. Oversampling was applied to eliminate the class imbalance, and proportional stratified sampling was used to construct the training/validation sample libraries. A CNN architecture that is suitable for the prediction of forest fire susceptibility was designed and hyperparameters were optimized to improve the prediction accuracy. Then, the test dataset was fed into the trained model to construct the spatial prediction map of forest fire susceptibility in Yunnan Province. Finally, the prediction performance of the proposed model was assessed using several statistical measures—Wilcoxon signed-rank test, receiver operating characteristic curve, and area under the curve (AUC). The results confirmed the higher accuracy of the proposed CNN model (AUC 0.86) than those of the random forests, support vector machine, multilayer perceptron neural network, and kernel logistic regression benchmark classifiers. The CNN has stronger fitting and classification abilities and can make full use of neighborhood information, which is a promising alternative for the spatial prediction of forest fire susceptibility. This research extends the application of CNN to the prediction of forest fire susceptibility.
The role of inequity aversion in microloan defaults
Authors: JORDAN MATTHEW R. , DICKENS WILLIAM T. , HAUSER OLIVER P. , RAND DAVID G. 
Published: September 2019

AbstractMicrocredit – joint-liability loans to the poorest of the poor – has been touted as a powerful approach for combatting global poverty, but sustainability varies dramatically across banks. Efforts to improve the sustainability of microcredit have assumed defaults are caused by free-riding. Here, we point out that the response of other group members to delinquent groupmates also plays an important role in defaults. Even in the absence of any free-rider problem, some people will be unable to make their payments due to bad luck. It is other group members’ unwillingness to pitch in extra – due to, among other things, not wanting to have less than other group members – that leads to default. To support this argument, we utilize the Ultimatum Game (UG), a standard paradigm from behavioral economics for measuring one's aversion to inequitable outcomes. First, we show that country-level variation in microloan default rates is strongly correlated (overall r = 0.81) with country-level UG rejection rates, but not free-riding measures. We then introduce a laboratory model ‘Microloan Game’ and present evidence that defaults arise from inequity-averse individuals refusing to make up the difference when others fail to pay their fair share. This perspective suggests a suite of new approaches for combatting defaults that leverage findings on reducing UG rejections.
EROS AT JUNNAR: RECONSIDERING A PIECE OF MEDITERRANEAN ART
Authors: Cobb Matthew Adam , Mitchell Fiona 
Published: September 2019

In 1969 on a riverside near the Lenyardi caves (about 5 kilometres from present-day Junnar, in the Indian state of Maharashtra), Dr Satish Deshmukh discovered an alabaster object in the form of half an egg (longitudinally cut) with a young male child lying inside it (with small traces of red paint on the right side of the object). This high-quality oval object (figures 1 and 2) measures about 5 cm × 3.4 cm and is usually interpreted as an item that was originally manufactured in the Mediterranean world before being brought to India, rather than a piece of artwork produced in India itself. One possible, and largely accepted, interpretation is that this figure represents the birth of the god Eros. However, identification of the figure within the egg-like structure is not easily made. While the figure does bear similarities to the putto-style representation of Eros in instances of Greek and Roman art, it does not possess any clear identifying features (such as the wings with which Eros is often depicted). The figure's resemblance to Eros in some of his other iconographic depictions and the egg-like structure around him suggest a possible identification of this infant with Eros and the myth of his birth from an egg. However, without evidence from other iconography of a more clearly identifiable Eros in similar contexts, the figure cannot be said to be him with any certainty. As Dhavalikar notes, this object ‘is the only one of its kind among the classical antiquities so far found in the Indian subcontinent and perhaps has no parallel in the classical world’. Thus the identification of this sculpture as a depiction of Eros in the egg is possible, but not certain.
A systematic review of factors affecting choice of otolaryngology as a career in medical students and junior doctors
Authors: Mayer A W , Smith K A , Carrie S 
Published: September 2019

AbstractBackgroundThere is growing concern over a future shortfall in provision of UK otolaryngology consultants. There is a declining rate of applications to otolaryngology specialty training in the UK.ObjectiveThis study aimed to systematically review the literature to establish what factors influence medical students’ and junior doctors’ decision to pursue a career in otolaryngology.MethodMedline, Embase and PubMed databases were searched in January 2019. Additional manual reference checks of identified literature were performed.ResultsEleven articles were included in the review. Common factors that positively influenced the decision to pursue a career in otolaryngology were exposure to the specialty, positive role models and a good work-life balance. Lack of exposure was a consistent deterrent from pursuing a career in otolaryngology.ConclusionThis review reiterates the need for greater exposure to otolaryngology in the undergraduate curriculum. In addition, mentorship for students with an interest in otolaryngology should be a priority.
Molecular confirmation and description of the larval morphology of Thalassocaris lucida (Dana, 1852) (Decapoda, Caridea, Pandaloidea)
Authors: Landeira José María , Yang Chien-Hui , Komai Tomoyuki , Chan Tin-Yam , Wakabayashi Kaori 
Published: September 2019

AbstractThe morphology of the zoeal stages IX and XI of the shrimp Thalassocaris lucida is described and illustrated in detail from plankton specimens identified by barcoding of the mitochondrial 16S ribosomal RNA gene (sequence similarities 99.4–99.6%). The present study confirms the larval morphology of Thalassocaris, that shows distinct features within Pandaloidea: (1) carapace broad and dorsoventrally flattened, (2) coxal endite of maxilla with only one lobe, (3) basis of third maxilliped with a distal globose lobe. On the other hand, the funnel-shaped eyes, and the development with long series of larval stages of Thalassocaris indicate affinities with some genera of Pandalidae which corroborates the results of recent phylogenetic analyses in abandoning the family status of Thalassocarididae.
Herodotus in The Theatre at Alexandria? On Athenaeus 14.620D
Authors: Matijašić Ivan 
Published: September 2019

AbstractThis article discusses a passage in Athenaeus (14.620d) that refers to the performance of Herodotus’ work in a theatre in Hellenistic Alexandria. In his edition of Athenaeus, highly valued and still influential, August Meineke replaces Herodotus’ name (unanimously transmitted in Athenaeus’ manuscripts) with Hesiod’s. In this article I set out to overturn a widespread tendency to accept Meineke’s emendation of Athenaeus 14.620d, reconsidering the possibility that Athenaeus did in fact name Herodotus in the light of (a) the difficulty of explaining the origin of the alleged mistake in Athenaeus’ manuscript tradition and (b) the ancients’ tendency to draw parallels between Herodotus’ style and language and Homeric poetry. The fact that Athenaeus refers to theatrical performances of both Herodotus’ work and the Homeric poems will be shown to be very much in line with the ancient rhetorical, historiographical and biographical tradition which regarded Herodotus as the most Homeric of all prose writers.
Copper physiology in ruminants: trafficking of systemic copper, adaptations to variation in nutritional supply and thiomolybdate challenge
Authors: Clarkson A. H. , Paine S. , Martín-Tereso J. , Kendall N. R. 
Published: September 2019

AbstractRuminants are recognised to suffer from Cu-responsive disorders. Present understanding of Cu transport and metabolism is limited and inconsistent across vets and veterinary professionals. There has been much progress from the studies of the 1980s and early 1990s in cellular Cu transport and liver metabolism which has not been translated into agricultural practice. Cu metabolism operates in regulated pathways of Cu trafficking rather than in pools of Cu lability. Cu in the cell is chaperoned to enzyme production, retention within metallothionein or excretion via the Golgi into the blood. The hepatocyte differs in that Cu-containing caeruloplasmin can be synthesised to provide systemic Cu supply and excess Cu is excreted via bile. The aim of the present review is to improve understanding and highlight the relevant progress in relation to ruminants through the translation of newer findings from medicine and non-ruminant animal models into ruminants.
Thiamine deficiency in a patient with recurrent renal cell carcinoma who developed weight loss with normal appetite and loss of energy soon after nivolumab treatment
Authors: Onishi Hideki , Okabe Takashi , Uchida Nozomu , Shirotake Suguru , Todo Maki , Oyama Masafumi , Ishida Mayumi 
Published: September 2019

AbstractBackgroundNivolumab has become an effective treatment option for cancer in various sites; however, this drug may cause immune-related adverse effects due to its mechanism of action. Furthermore, little has been reported on thiamine deficiency (TD) in patients receiving nivolumab treatment.MethodFrom a series of cancer patients, we reported a patient with recurrent renal cell carcinoma who developed TD after the start of nivolumab treatment.ResultsA 74-year-old man with recurrent renal cell carcinoma was referred to the psycho-oncology department as he had lost about 4 kg and displayed a loss of energy after four cycles of nivolumab treatment. Psychiatric interviews revealed a decrease in energy. Neurological examination did not reveal any impairment in consciousness, ataxia, or ocular symptoms. He did not develop appetite loss. The malabsorption or overconsumption of some nutrients is thought to occur due to the rapid loss of weight; thus, a reduction in vitamin B1, which has a short storage period in the body and is often deficient in cancer patients, was suspected. The diagnosis of TD was supported by the patient's abnormally low serum thiamine level.Significance of resultsIn patients treated with nivolumab, it is necessary to pay careful attention to TD when proceeding with the treatment. It is hoped that future research may reveal the link between nivolumab administration and TD.
Development of a German version of the Carer Support Needs Assessment Tool (CSNAT): The process of translation and cultural adaptation
Authors: Kreyer Christiane , Bükki Johannes , Pleschberger Sabine 
Published: September 2019

AbstractObjectiveThe Carer Support Needs Assessment Tool (CSNAT) was developed in the UK and has been shown to be effective to assess and address support needs of family carers of terminally ill patients at home. In German language, there is a lack of an evidence-based comprehensive assessment tool for family carers in palliative home care. The objectives of this study were to translate and develop a culturally adapted version of the CSNAT for a German-speaking context including the assessment of feasibility, face, and content validity.MethodA translation and validation study was conducted in three steps: (1) translation of CSNAT following International Society for Pharmacoeconomics and Outcomes Research criteria; (2) cognitive testing in five German-speaking regions in Germany, Austria, and Switzerland with 15 family carers; and (3) pilot testing in palliative home care services. Evaluation was by telephone interviews with those involved in the assessments (family carers, health care professionals) and a focus group discussion with the health care professionals. Data were analyzed using content analysis.ResultsThe regional idiomatic variety raised challenges in the process of translation. Cognitive testing revealed semantic, conceptual, syntactic, and idiomatic issues. During the pilot, 25 assessment conversations were held. Carers reported that the German version called “KOMMA” was brief, easy to understand and to complete, and helpful. They appreciated that the items adequately addressed their support needs and reminded them of their own strengths and resources. Health care professionals observed good acceptance by carers, the expression of unexpected patterns of needs, and extensive assessment conversations, but some raised concerns that the assessment process might shift attention to carers’ needs at the cost of the patients.Significance of resultsA multi-step process of translation, cognitive testing, and pilot testing led to a culturally well-acceptable German tool (KOMMA). Comprehensibility, acceptance, face, and content validity, as well as feasibility were demonstrated.
HPD degradation regulated by the TTC36-STK33-PELI1 signaling axis induces tyrosinemia and neurological damage
Authors: Xie Yajun , Lv Xiaoyan , Ni Dongsheng , Liu Jianing , Hu Yanxia , Liu Yamin , Liu Yunhong , Liu Rui , Zhao Hui , Lu Zhimin , Zhou Qin 
Published: September 2019

AbstractDecreased expression of 4-hydroxyphenylpyruvic acid dioxygenase (HPD), a key enzyme for tyrosine metabolism, is a cause of human tyrosinemia. However, the regulation of HPD expression remains largely unknown. Here, we demonstrate that molecular chaperone TTC36, which is highly expressed in liver, is associated with HPD and reduces the binding of protein kinase STK33 to HPD, thereby inhibiting STK33-mediated HPD T382 phosphorylation. The reduction of HPD T382 phosphorylation results in impaired recruitment of FHA domain-containing PELI1 and PELI1-mediated HPD polyubiquitylation and degradation. Conversely, deficiency or depletion of TTC36 results in enhanced STK33-mediated HPD T382 phosphorylation and binding of PELI1 to HPD and subsequent PELI1-mediated HPD downregulation. Ttc36−/− mice have reduced HPD expression in the liver and exhibit tyrosinemia, damage to hippocampal neurons, and deficits of learning and memory. These findings reveal a previously unknown regulation of HPD expression and highlight the physiological significance of TTC36-STK33-PELI1-regulated HPD expression in tyrosinemia and tyrosinemia-associated neurological disorders.
Discovering genetic interactions bridging pathways in genome-wide association studies
Authors: Fang Gang , Wang Wen , Paunic Vanja , Heydari Hamed , Costanzo Michael , Liu Xiaoye , Liu Xiaotong , VanderSluis Benjamin , Oately Benjamin , Steinbach Michael , Van Ness Brian , Schadt Eric E. , Pankratz Nathan D. , Boone Charles , Kumar Vipin , Myers Chad L. 
Published: September 2019

AbstractGenetic interactions have been reported to underlie phenotypes in a variety of systems, but the extent to which they contribute to complex disease in humans remains unclear. In principle, genome-wide association studies (GWAS) provide a platform for detecting genetic interactions, but existing methods for identifying them from GWAS data tend to focus on testing individual locus pairs, which undermines statistical power. Importantly, a global genetic network mapped for a model eukaryotic organism revealed that genetic interactions often connect genes between compensatory functional modules in a highly coherent manner. Taking advantage of this expected structure, we developed a computational approach called BridGE that identifies pathways connected by genetic interactions from GWAS data. Applying BridGE broadly, we discover significant interactions in Parkinson’s disease, schizophrenia, hypertension, prostate cancer, breast cancer, and type 2 diabetes. Our novel approach provides a general framework for mapping complex genetic networks underlying human disease from genome-wide genotype data.
Genetic determinants of cellular addiction to DNA polymerase theta
Authors: Feng Wanjuan , Simpson Dennis A. , Carvajal-Garcia Juan , Price Brandon A. , Kumar Rashmi J. , Mose Lisle E. , Wood Richard D. , Rashid Naim , Purvis Jeremy E. , Parker Joel S. , Ramsden Dale A. , Gupta Gaorav P. 
Published: September 2019

AbstractPolymerase theta (Pol θ, gene name Polq) is a widely conserved DNA polymerase that mediates a microhomology-mediated, error-prone, double strand break (DSB) repair pathway, referred to as Theta Mediated End Joining (TMEJ). Cells with homologous recombination deficiency are reliant on TMEJ for DSB repair. It is unknown whether deficiencies in other components of the DNA damage response (DDR) also result in Pol θ addiction. Here we use a CRISPR genetic screen to uncover 140 Polq synthetic lethal (PolqSL) genes, the majority of which were previously unknown. Functional analyses indicate that Pol θ/TMEJ addiction is associated with increased levels of replication-associated DSBs, regardless of the initial source of damage. We further demonstrate that approximately 30% of TCGA breast cancers have genetic alterations in PolqSL genes and exhibit genomic scars of Pol θ/TMEJ hyperactivity, thereby substantially expanding the subset of human cancers for which Pol θ inhibition represents a promising therapeutic strategy.
MRE11-RAD50-NBS1 promotes Fanconi Anemia R-loop suppression at transcription–replication conflicts
Authors: Chang Emily Yun-Chia , Tsai Shuhe , Aristizabal Maria J. , Wells James P. , Coulombe Yan , Busatto Franciele F. , Chan Yujia A. , Kumar Arun , Dan Zhu Yi , Wang Alan Ying-Hsu , Fournier Louis-Alexandre , Hieter Philip , Kobor Michael S. , Masson Jean-Yves , Stirling Peter C. 
Published: September 2019

AbstractEctopic R-loop accumulation causes DNA replication stress and genome instability. To avoid these outcomes, cells possess a range of anti-R-loop mechanisms, including RNaseH that degrades the RNA moiety in R-loops. To comprehensively identify anti-R-loop mechanisms, we performed a genome-wide trigenic interaction screen in yeast lacking RNH1 and RNH201. We identified >100 genes critical for fitness in the absence of RNaseH, which were enriched for DNA replication fork maintenance factors including the MRE11-RAD50-NBS1 (MRN) complex. While MRN has been shown to promote R-loops at DNA double-strand breaks, we show that it suppresses R-loops and associated DNA damage at transcription–replication conflicts. This occurs through a non-nucleolytic function of MRE11 that is important for R-loop suppression by the Fanconi Anemia pathway. This work establishes a novel role for MRE11-RAD50-NBS1 in directing tolerance mechanisms at transcription–replication conflicts.
Exploiting biofilm phenotypes for functional characterization of hypothetical genes in Enterococcus faecalis
Authors: Willett Julia L. E. , Ji Michelle M. , Dunny Gary M. 
Published: September 2019

AbstractEnterococcus faecalis is a commensal organism as well as an important nosocomial pathogen, and its infections are typically linked to biofilm formation. Nearly 25% of the E. faecalis OG1RF genome encodes hypothetical genes or genes of unknown function. Elucidating their function and how these gene products influence biofilm formation is critical for understanding E. faecalis biology. To identify uncharacterized early biofilm determinants, we performed a genetic screen using an arrayed transposon (Tn) library containing ~2000 mutants in hypothetical genes/intergenic regions and identified eight uncharacterized predicted protein-coding genes required for biofilm formation. We demonstrate that OG1RF_10435 encodes a phosphatase that modulates global protein expression and arginine catabolism and propose renaming this gene bph (biofilm phosphatase). We present a workflow for combining phenotype-driven experimental and computational evaluation of hypothetical gene products in E. faecalis, which can be used to study hypothetical genes required for biofilm formation and other phenotypes of diverse bacteria.