bluuebunny/crossref_metadata_2025_split huggingface dataset:
Immobilization of cadmium and lead in contaminated paddy field using inorganic and organic additives
Authors: Hamid Yasir , Tang Lin , Wang Xiaozi , Hussain Bilal , Yaseen Muhammad , Aziz Muhammad Zahir , Yang Xiaoe 
Published: December 2018

AbstractHeavy metal contamination of agricultural soils has posed a risk to environment and human health. The present study was conducted to assess the effectiveness of soil amendments for reducing cadmium (Cd) and lead (Pb) uptake by rice (Oryza sativa L) in a contaminated field. The soil amendments used include lime, DaSan Yuan (DASY), DiKang No.1 (DEK1), biochar, Fe-biochar, Yirang, phosphorus fertilizer, (Green Stabilizing Agent) GSA-1, GSA-2, GSA-3, and GSA-4, applied at 1% rate in a field experiment. The results exposed that GSA-4 treatment showed best effects on reducing Cd and Pb phytoavailability in soil and uptake by early rice. Linear increase in pH (i.e. 5.69 to 6.75) was recorded in GSA-4 amended soil from sowing to the 3rd month of growth season. GSA-4 decreased DTPA extractable contents of cadmium (Cd) from 0.324 to 0.136 mg kg−1 soil and lead (Pb) from 53.21 to 24.68 mg kg−1 soil at 90 days of amendment. Treatment with GSA-4 improved rice growth (56%) and grains yield (42%). The enhancement effects on grain yield may be result from the positive effects of GSA-4 application on increasing photosynthesis (116%) and transpiration rate (152%) as compared to the control. Significant reduction in Cd and Pb uptake in shoot (42% and 44%) and in grains (77 and 88%), was observed, respectively in GSA-4 treatment as compared with the control. Moreover, negative correlation was recorded between DTPA extractable Cd/Pb and soil pH that directly depended on applied amendments. In short, use of combined amendment (GSA-4) was more effective for immobilizing heavy metals in contaminated paddy field, and secures rice safe production, as compared other tested amendment products.
Complementary topology of maintenance and manipulation brain networks in working memory
Authors: Davis S. W. , Crowell C. A. , Beynel L. , Deng L. , Lakhlani D. , Hilbig S. A. , Lim W. , Nguyen D. , Peterchev A. V. , Luber B. M. , Lisanby S. H. , Appelbaum L. G. , Cabeza R. 
Published: December 2018

AbstractWorking memory (WM) is assumed to consist of a process that sustains memory representations in an active state (maintenance) and a process that operates on these activated representations (manipulation). We examined evidence for two distinct, concurrent cognitive functions supporting maintenance and manipulation abilities by testing brain activity as participants performed a WM alphabetization task. Maintenance was investigated by varying the number of letters held in WM and manipulation by varying the number of moves required to sort the list alphabetically. We found that both maintenance and manipulation demand had significant effects on behavior that were associated with different cortical regions: maintenance was associated with bilateral prefrontal and left parietal cortex, and manipulation with right parietal activity, a link that is consistent with the role of parietal cortex in symbolic computations. Both structural and functional architecture of these systems suggested that these cognitive functions are supported by two dissociable brain networks. Critically, maintenance and manipulation functional networks became increasingly segregated with increasing demand, an effect that was positively associated with individual WM ability. These results provide evidence that network segregation may act as a protective mechanism to enable successful performance under increasing WM demand.
Epidemiological Characteristics of Atrial Fibrillation in Southern China: Results from the Guangzhou Heart Study
Authors: Deng Hai , Guo Pi , Zheng Murui , Huang Jun , Xue Yumei , Zhan Xianzhang , Wang Feng , Liu Yang , Fang Xianhong , Liao Hongtao , Wei Wei , Liang Yuanhong , Liu Fangzhou , Liao Zili , Feng Yijing , Wu Shulin 
Published: December 2018

AbstractPrecise prevalence of atrial fibrillation (AF) and the associated risk factors in southern China are rarely reported. This large population-based follow-up study, the Guangzhou Heart Study, was conducted from 2015 to 2017 to fill up this gap. Permanent residents aged 35 years and above in Guangzhou city were enrolled and demographic factors of participants were collected by a structured questionnaire. Examinations of physical, electrocardiographic and biochemical indicators were performed following a standard operation procedure designed prior to the field investigation. Descriptive statistics were used to evaluate basic characteristics of the study participants, and multivariate logistic regression model was performed to assess the AF prevalence-related factors. The detailed study design, the baseline characteristics and the prevalence of AF were reported here. In total, 12,013 residents were enrolled, and the percentage of participants from rural and urban areas was 53.92% and 46.08%, respectively. In total, 90.57% participants aged 40–79 years old and the proportion of women was more than men (64.98% vs. 35.02%). Overall, the prevalence of AF among the participants was 1.46%. Increasing age, male sex and widowed marital status were associated with higher AF prevalence (P-value < 0.05). The prevalence of AF increased with age and climbed to approximately 5% in residents aged 80 years and over. Residents with abnormal higher blood level of total cholesterol tended to have a lower AF prevalence but a higher prevalence of AF was observed in female participants with lower level of high density lipoprotein cholesterol land higher level uric acid (all P-value < 0.05). Personal illness such as hypertension, diabetes mellitus, dyslipidemia, myocardial infarction, heart failure, stroke and transient ischemic were significantly linked to the attack of AF (all P-value < 0.05). This study will be rich resource for investigating environmental exposure and individual genetic diathesis of AF and other common cardiovascular diseases in Chinese population.
Analysis of expression of the PD-1/PD-L1 immune checkpoint system and its prognostic impact in gastroenteropancreatic neuroendocrine tumors
Authors: Sampedro-Núñez Miguel , Serrano-Somavilla Ana , Adrados Magdalena , Cameselle-Teijeiro José M. , Blanco-Carrera Concepción , Cabezas-Agricola José Manuel , Martínez-Hernández Rebeca , Martín-Pérez Elena , Muñoz de Nova José Luis , Díaz José Ángel , García-Centeno Rogelio , Caneiro-Gómez Javier , Abdulkader Ihab , González-Amaro Roberto , Marazuela Mónica 
Published: December 2018

AbstractThe immune checkpoint based therapy targeting the programmed death-1 (PD-1) receptor and its PD-L1 ligand has recently been approved for the therapy of different malignant conditions, but not yet for gastroenteropancreatic neuroendocrine tumors (GEP-NETs). In this context, we evaluated the expression of PD-1 and PD-L1 in GEP-NETs and its potential correlations with clinical outcomes. Expression of PD-1/PD-L1 was analyzed by immunohistochemistry in 116 GEP-NETs and 48 samples of peritumoral tissue. In addition, the expression of these molecules was assessed by flow cytometry in peripheral blood mononuclear cells (PBMC) from patients with GEP-NETs (n = 32) and healthy controls (n = 32) and in intratumoral mononuclear cells (TMCs) (n = 3). Expression of PD-L1 and PD-1 was detected by immunohistochemistry in 6% and 1% of tumor tissue samples, respectively, and in 8% of peritumoral tissue samples, for both markers. We also observed that PD-1 expression by TMCs was associated with metastatic disease at diagnosis, and the levels of circulating PD-1+ PBMCs were associated with progressive disease upon follow-ups. In addition, circulating PD-1+ PBMCs were significantly correlated with PD-L1 expression by tumor cells. Our data suggest that PD-1/PD-L1 is expressed in 1 to 8% of GEP-NETs, and that this feature is significantly associated with disease evolution (p < 0.01).
Asclepias Syriaca (Common Milkweed) flowering date shift in response to climate change
Authors: Howard Aaron F. 
Published: December 2018

AbstractThe consequences of altered flowering dates due to climate change can be severe, especially for plants that rely on coordinated flower and pollinator emergence for reproduction. The plant Asclepias syriaca (Common Milkweed) relies on pollinators for movement of its pollen and evidence suggests that it has recently been declining. Given these factors and this plant’s importance as a host species for the declining Danaus plexippus (Monarch Butterfly), it is critical to determine if its flowering is being modified by climate change. As a first step to answering this question I quantified the relationship between climate and flowering date for A. syriaca using data from the USA National Phenology Network repository and the National Oceanic and Atmospheric Administration. I found that temperatures were higher than they had been historically (1895–2010) and mean flowering dates occurred earlier with higher temperatures. Additionally, there is a significant negative interactive effect of temperature and year on flowering date indicating that from 2011 through 2016 higher temperatures are correlated with increasingly earlier flowering dates. The change in flowering appears to be symmetrical in regards to the flowering time distribution, in that along with the mean, both maximum and minimum flowering dates are occurring earlier, as well. There is no evidence that earlier flowering is due to earlier initial growth or results in later fruit ripening. Consequences of this shift in flowering can only be speculated upon at this point, but due to the ecological importance of A. syriaca and its susceptibility to phenological mismatch, they should be considered when developing conservation plans for A. syriaca and the organisms for which it is a host.
Characterisation of small molecule ligands 4CMTB and 2CTAP as modulators of human FFA2 receptor signalling
Authors: Schofield Zoe V. , Croker Daniel , Robertson Avril A. B. , Massey Nicholas L. , Donovan Chantal , Tee Ernest , Edwards David , Woodruff Trent M. , Halai Reena , Hansbro Philip M. , Cooper Matthew A. 
Published: December 2018

AbstractShort chain fatty acids (SCFAs) are protective against inflammatory diseases. Free fatty acid receptor 2 (FFA2), is a target of SCFAs however, their selectivity for FFA2 over other FFA receptors is limited. This study aimed to functionally characterise 2-(4-chlorophenyl)-3-methyl-N-(thiazole-2-yl)butanamide (4CMTB) and 4-((4-(2-chlorophenyl)thiazole-2-yl)amino)-4oxo-3-phenylbutanoic acid (2CTAP), and their enantiomers, in modulating FFA2 activity. The racemic mixture (R/S) and its constituents (R-)and (S-) 4CMTB or 2CTAP were used to stimulate human (h)FFA2 in the absence or presence of acetate. Calcium ions (Ca2+), phosphorylated extracellular signal-regulated kinase 1 and 2 (pERK1/2) and cyclic adenosine monophosphate (cAMP) were measured.R/S-4CMTB is a functionally selective ago-allosteric ligand that enhances Ca2+response to acetate. BothR/S-4CMTB andS-4CMTB are more potent activators of pERK1/2 and inhibitors of forskolin-induced cAMP than acetate.S-4CMTB increased neutrophil infiltration in intestinal ischemia reperfusion injury (IRI). 2CTAP inhibited constitutive Ca2+levels, antagonised acetate-induced pERK1/2 and prevented damage following IRI. This study characterises enantiomers of functionally selective ligands for FFA2 in cells stably expressing hFFA2. It highlights the novel roles of selective FFA2 enantiomers 4CMTB and 2CTAP on Ca2+, pERK1/2 and cAMP and their roles as allosteric modulators which, may assist in efforts to design novel therapeutic agents for FFA2-driven inflammatory diseases.
Plasma-induced unconventional shock waves on oil surfaces
Authors: Li Guoliang , Hu Ruiheng , Tang Jau , Zheng Huai , Liu Sheng 
Published: December 2018

AbstractElectric corona discharge in a multi-phase system results in complex electro-hydrodynamic phenomena. We observed unconventional shock wave propagation on an oil thin film sprayed over a polymer-coated conductor. A hair-thin single shock wave arose when the high voltage bias of an overhung steel needle was abruptly removed. However, such solitary waves possess neither interference nor reflection properties commonly known for ordinary waves, and also differ from the solitons in a canal or an optical fiber. We also observed time-retarded movement for dispersed oil droplets at various distances from the epicenter which have no physical contact, as if a wave propagating on a continuous medium. Such a causality phenomenon for noncontact droplets to move resembling wave propagation could not be possibly described by the conventional surface wave equation. Our systematic studies reveal a mechanism involving oil surface charges driven by reminiscent electric fields in the air when the needle bias is suddenly removed.
Augmentation of Atrazine biodegradation by two Bacilli immobilized on α-Fe2O3 magnetic nanoparticles
Authors: Khatoon Hina , Rai J. P. N. 
Published: December 2018

AbstractIn this study, a novel immobilizing carrier with α-Fe2O3 magnetic nanoparticles was developed and used for immobilization of atrazine-degrading bacterial isolates of Bacillus spp. Since the free cells of microorganisms generally not succeed to degrade pollutants; thus, extra treatments are alluring to make strides biodegradation. Scanning electron microscope (SEM) images appeared that after immobilization the bacterial cells were totally retained and entirely distributed on the surface of α-Fe2O3 magnetic nanoparticles. The performance of α-Fe2O3 immobilized cells in atrazine (ATZ) degradation was compared with the free cells, which was about 90.56% in 20 days. Experimental results exhibited that ATZ could be degraded at a broad range of physicochemical parameters viz. pH (4.0 to 9.0), temperature (20 to 45 °C), ATZ concentration (50 to 300 mg L−1) and agitation speed (50 to 300 rpm), which underlines that α-Fe2O3 immobilized cells could tolerate a higher range of ATZ concentration as compared to free cells. This research demonstrated that α-Fe2O3 could be applied as a potential carrier in cell immobilization and biodegradation of ATZ herbicide with greater efficiency.
Impact of CFTR modulation with Ivacaftor on Gut Microbiota and Intestinal Inflammation
Authors: Ooi Chee Y. , Syed Saad A. , Rossi Laura , Garg Millie , Needham Bronwen , Avolio Julie , Young Kelsey , Surette Michael G. , Gonska Tanja 
Published: December 2018

AbstractCystic fibrosis (CF) is caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. Next to progressive airway disease, CF is also associated with intestinal inflammation and dysbiosis. Ivacaftor, a CFTR potentiator, has improved pulmonary and nutritional status but its effects on the intestinal microbiota and inflammation are unclear. Hence, we assessed the changes on the intestinal microbial communities (16S rRNA variable 3 gene region) and inflammatory markers (calprotectin and M2-pyruvate kinase [M2-PK]) in 16 CF individuals (8 children and 8 adults) before and after (median 6.1 months) ivacaftor. Stool calprotectin significantly decreased following ivacaftor (median [IQR]: 154.4 [102.1–284.2] vs. 87.5 [19.5–190.2] mg/kg, P = 0.03). There was a significant increase in Akkermansia with ivacaftor. Increased abundance of Akkermansia was associated with normal stool M2-PK concentrations, and decreased abundances of Enterobacteriaceae correlated with decreased stool calprotectin concentrations. In summary, changes in the gut microbiome and decrease in intestinal inflammation was associated with Ivacaftor treatment among individuals with CF carrying at least one gating CFTR mutation. Thus, CFTR-modifying therapy may adequately improve the aberrant pathophysiology and milieu of the CF gut to favor a more healthy microbiota, which in turn reduces intestinal inflammation.
Integrin αvβ6 plays a bi-directional regulation role between colon cancer cells and cancer-associated fibroblasts
Authors: Peng Cheng , Zou Xueqing , Xia Wanying , Gao Huijie , Li Zequn , Liu Naiqing , Xu Zongquan , Gao Chao , He Zhaobin , Niu Weibo , Fang Ruliang , Biswas Siddhartha , Agrez Michael , Zhi Xuting , Niu Jun 
Published: December 2018

Tumor microenvironment (TME) is the cellular environment in which tumor exists, and it contributes to tumor formation and progression. The TME is composed of tumor cells, stromal cells, cytokines, and chemotactic factors of which fibroblasts are the main cellular components. In our present study, we found that colorectal cancer (CRC) cells expressing integrin αvβ6 clearly could induce morphological changes in inactive fibroblasts and increased the expression of activated fibroblast markers such as α-smooth muscle actin (α-SMA) and fibroblast-activating protein (FAP). Those activated fibroblasts in the TME are called cancer-associated fibroblasts (CAFs). In order to investigate the mechanism by which CRC cells expressing integrin αvβ6 activated CAFs, a series of assays have been carried out in the follow-up. We found that CRC cells could secrete inactive transforming growth factor β (TGF-β); however, integrin αvβ6 activated TGF-β, which subsequently activated fibroblasts. This process was disrupted by knockdown of integrin αvβ6. In contrast, activated fibroblasts could promote CRC cell invasion. In particular, the strengthening effect on expression of integrin αvβ6 in colon cancer cells was obvious. Additionally, we found that CAFs could secrete stromal cell-derived factor-1 (SDF-1) and promote CRC cell metastasis in distant organs via the SDF-1/C–X–C chemokine receptor type 4 (CXCR4) axis. Taken together, we assumed that CRC cells and CAFs activated one another and worked together to promote cancer progression, with integrin αvβ6 playing a role in the bi-directional regulation of these cells. Hence, integrin αvβ6 may serve as a therapeutic target for the future CRC treatment.
Apoptosis and apoptotic body: disease message and therapeutic target potentials
Authors: Xu Xuebo , Lai Yueyang , Hua Zi-Chun 
Published: December 2018

AbstractApoptosis is widely known as programmed cell death eliciting no inflammatory responses. The intricacy of apoptosis has been a focus of an array of researches, accumulating a wealth of knowledge which led to not only a better understanding of the fundamental process, but also potent therapies of diseases. The classic intrinsic and extrinsic signaling pathways of apoptosis, along with regulatory factors have been well delineated. Drugs and therapeutic measures designed based on current understanding of apoptosis have long been employed. Small-molecule apoptosis inducers have been clinically used for eliminating morbid cells and therefore treating diseases, such as cancer. Biologics with improved apoptotic efficacy and selectivity, such as recombinant proteins and antibodies, are being extensively researched and some have been approved by the FDA. Apoptosis also produces membrane-bound vesicles derived from disassembly of apoptotic cells, now known as apoptotic bodies (ApoBDs). These little sealed sacs containing information as well as substances from dying cells were previously regarded as garbage bags until they were discovered to be capable of delivering useful materials to healthy recipient cells (e.g., autoantigens). In this review, current understandings and knowledge of apoptosis were summarized and discussed with a focus on apoptosis-related therapeutic applications and ApoBDs.
Extreme fragmentation and complex kinematics at the center of the L1287 cloud
Authors: Juárez Carmen , Liu Hauyu Baobab , Girart Josep M. , Palau Aina , Busquet Gemma , Galván-Madrid Roberto , Hirano Naomi , Lin Yuxin 
Published: December 2018

Aims. The filamentary ~10-pc-scale infrared dark cloud L1287 located at a parallax distance of ~929 pc is actively forming a dense cluster of low-mass young stellar objects (YSOs) at its inner ~0.1 pc region. To help understand the origin of this low-mass YSO cluster, the present work aims at resolving the gas structures and kinematics with high angular resolution.
Methods. We performed ~1′′ angular resolution (~930 AU) observations at ~1.3 mm wavelengths using the Submillimeter Array (SMA), which simultaneously cover the dust continuum emission and various molecular line tracers for dense gas, warm gas, shocks, and outflows.
Results. From a 1.3-mm continuum image with a resolution of ~2′′ we identified six dense cores, namely SMA1-6. Their gas masses are in the range of ~0.4–4 M⊙. From a 1.3-mm continuum image with a resolution of ~1′′, we find a high fragmentation level, with 14 compact millimeter sources within 0.1 pc: SMA3 contains at least nine internal condensations; SMA5 and SMA6 are also resolved with two internal condensations. Intriguingly, one condensation in SMA3 and another in SMA5 appear associated with the known accretion outburst YSOs RNO 1C and RNO 1B. The dense gas tracer DCN (3–2) well traces the dust continuum emission and shows a clear velocity gradient along the NW-SE direction centered at SMA3. There is another velocity gradient with opposite direction around the most luminous YSO, IRAS 00338 + 6312.
Conclusions. The fragmentation within 0.1 pc in L1287 is very high compared to other regions at the same spatial scales. The incoherent motions of dense gas flows are sometimes interpreted by being influenced by (proto)stellar feedback (e.g., outflows), which is not yet ruled out in this particular target source. On the other hand, the velocities (with respect to the systemic velocity) traced by DCN are small, and the directions of the velocity gradients traced by DCN are approximately perpendicular to those of the dominant CO outflow(s). Therefore, we alternatively hypothesize that the velocity gradients revealed by DCN trace the convergence from the ≳0.1 pc scales infalling motion towards the rotational motions around the more compact (~0.02 pc) sources. This global molecular gas converging flow may feed the formation of the dense low-mass YSO cluster. Finally, we also found that IRAS 00338 + 6312 is the most likely powering source of the dominant CO outflow. A compact blue-shifted outflow from RNO 1C is also identified.
A homogeneous aa index: 2. Hemispheric asymmetries and the equinoctial variation
Authors: Lockwood Mike , Finch Ivan D. , Chambodut Aude , Barnard Luke A. , Owens Mathew J. , Clarke Ellen 
Published: December 2018

Paper 1 (Lockwood et al., 2018) generated annual means of a new version of the aa geomagnetic activity index which includes corrections for secular drift in the geographic coordinates of the auroral oval, thereby resolving the difference between the centennial-scale change in the northern and southern hemisphere indices, aaN and aaS. However, other hemispheric asymmetries in the aa index remain: in particular, the distributions of 3-hourly aaN and aaS values are different and the correlation between them is not high on this timescale (r = 0.66). In the present paper, a location-dependant station sensitivity model is developed using the am index (derived from a much more extensive network of stations in both hemispheres) and used to reduce the difference between the hemispheric aa indices and improve their correlation (to r = 0.79) by generating corrected 3-hourly hemispheric indices, aaHN and aaHS, which also include the secular drift corrections detailed in Paper 1. These are combined into a new, “homogeneous” aa index, aaH. It is shown that aaH, unlike aa, reveals the “equinoctial”-like time-of-day/time-of-year pattern that is found for the am index.
Was die Psyche stark macht
Authors: Maier Julia 
Published: December 2018

ZusammenfassungResilienz ist die Fähigkeit, belastende Situationen gelassen zu meistern. Das Gute daran: Sie ist erlernbar. Besonders Menschen in stressigen Berufen wie
der Pflege sollten gezielt ihre psychischen Widerstandskräfte stärken.