bluuebunny/crossref_metadata_2025_split huggingface dataset:
The pseudogene PTTG3P promotes cell migration and invasion in esophageal squamous cell carcinoma
Authors: Zhang Zhenhua , Shi Zhengyuan 
Published: July 2019

Abstract
Pseudogenes are pivotal funtional non-coding RNAs in tumorigenesis. Cumulative evidences have shown that pituitary tumor-transforming 3, pseudogene (PTTG3P), serves as an oncogene in multiple human cancers. However, its expression pattern, biological function, and potential targets in esophageal squamous cell carcinoma (ESCC) remain unknown. Here, by quantitative real-time polymerase chain reaction (qRT-PCR) in 50 cases of ESCC, we found that the expression of PTTG3P, PTTG1 and PTTG2 in esophageal squamous cancer tissues and cell lines were significantly higher than their normal counterparts (P<0.01). Spearman correlation analysis showed that the PTTG3P expression was positively correlated with the PTTG1 and PTTG2 expression in ESCC tissue samples (P<0.05). Additionally, the high expression of PTTG3P in ESCC was significantly correlated with tumor depth, lymph node invasion and TNM stage (P<0.05). We also assessed the function of PTTG3P in vitro by gain-of-function studies. Results showed that enhanced expression of PTTG3P stimulated the migration and invasion of ESCC cells, and promoted the expression level of PTTG1 and PTTG2 in vitro. Furthermore, PTTG3P fulfilled its oncogenic functions by positively regulating its parent gene PTTG1 and PTTG2. Overall, our study indicated that PTTG3P is distinctly overexpressed and exhibited oncogenic role in a PTTG1 and PTTG2 mediated manner in ESCC.
Assessment of water, sanitation and hygiene in HCFs: which tool to follow?
Authors: Patel Krupali , Kalpana Pachillu , Trivedi Poonam , Yasobant Sandul , Saxena Deepak 
Published: July 2019

Abstract
Water, sanitation and hygiene (WASH) is important to improve and maintain the quality of health care services. Improving and managing WASH services require strong and consistent monitoring mechanisms to measure progress and direct efforts where needs are greatest. Although several tools are available to assess WASH in health care facilities (HCFs), there is always a dilemma among the program managers to select an appropriate tool for the assessment of WASH. Thus, it was aimed to perform a descriptive review of all available WASH assessment tools and assist in reaching a consensus for an optimal tool to assess WASH in HCFs. For this descriptive review, PubMed, ScopeMed and Google Scholar were used to search all available tools for the assessment of WASH. All the tools available online since 1991 till July 2018 were included in the review. Globally, nine different WASH assessment tools were retrieved. The majority of them have their self-limitations on the basis of 11 selected indicators and were examined in all the retrieved tools. There are variability and overlapping components within the specific tools. Very few survey instruments including human resource (HR), supply, budget, patient/staff satisfaction and documentation for appropriateness of WASH were found to be neglected. The majority of instruments were based on the subjective assessment of WASH validating with microbiological surveillance and photo documentation. The descriptive review suggests that various tools are available for the assessment of WASH but none of them seem to be complete with all indicators and to have consensus for the elements. Therefore, there is a need to develop a robust and comprehensive tool for the assessment of WASH in HCFs.
Effects of intraplantar administration of Complete Freund’s Adjuvant (CFA) on rotarod performance in mice
Authors: Altarifi Ahmad , Alsalem Mohammad , Mustafa Ayman 
Published: July 2019

Abstract

Background and aims
Preclinical animal models are crucial to study pain mechanisms and assess antinociceptive effects of medications. One major problem with current animal behavioral models is their lack of face validity with human nociception and the vulnerability for false-positive results. Here, we evaluated the usefulness of rotarod as a new way to assess inflammatory nociception in rodents.

Methods
Adult male mice were injected with saline or Complete Freund’s Adjuvant (CFA) in the left hindpaws. Mechanical allodynia and rotarod performance were evaluated before and after the administration of CFA. Mechanical allodynia was measured using von Frey filaments. Long-term effect of CFA on rotarod performance was also assessed for 2 weeks.

Results
Our results showed that CFA administration decreased pain threshold and increased sensitivity to von Frey filaments compared to control group. In rotarod experiments, the starting speed of the rod rotation started at four RPM, and accelerated until it reached 40 RPM in 5 min. Rotarod performance was enhanced from day to day in the control group. However, rotarod performance in CFA group was attenuated after CFA administration, which was significant after 24 h compared to vehicle. This attenuation was blocked by ibuprofen. Haloperidol administration (positive control) produced similar results to CFA administration. CFA did not produce significant attenuation of rotarod performance after 1 week post-injection.

Conclusions
Collectively, our findings could encourage the use of rotarod assay to measure acute (but not chronic) inflammatory nociception as a useful tool in rodents.
Sequentially Deposited Compact and Pinhole-Free Perovskite Layers via Adjusting the Permittivity of the Conversion Solution
Authors: Becker Markus , Wark Michael 
Published: July 2019

Abstract
The preparation of compact and pinhole-free absorber layers is a major step towards device reproducibility and high performance for planar organic-inorganic perovskite solar cells. It is well known that the sequential deposition method exhibits some advantages over the common one-pot synthesis in terms of controlling the surface coverage. However, it still miscarries to produce pinhole-free layers from solution, mainly due to the occurrence of dissolution and recrystallisation processes. We show that by a careful choice of the permittivity of the alcoholic solvent in the conversion step the surface morphology can be finely modified, thereby yielding pinhole-free and compact absorber films comparable to that from vapour-assisted solution techniques. It is observed that the permittivity controls the intensity of the Ostwald ripening effect and that a low value of the former enables an in situ intercalation of precursor materials into the lead halide framework. We successfully prepared smooth and mirror-like perovskite surfaces that demonstrate enhanced optoelectronic properties and photovoltaic performance compared to films from the native two-step deposition in isopropanol. This strategy provides a facile approach for obtaining high-quality layers in the planar architecture by simple solution processing.
Novas Inferências sobre o Sítio Arqueológico Içara-01 a partir da Análise dos Remanescentes Humanos
Authors: Di Giusto Marina Nogueira , Wesolowski Veronica 
Published: July 2019

A partir de um projeto de pesquisa que objetivou averiguar o comportamento de marcadores osteológicos em remanescentes humanos na perspectiva da longa duração no litoral sul de Santa Catarina, foram obtidos interessantesresultados para o sítio conchífero Içara-01. Foram analisados os marcadores de estresse osteológicos de Hiperostose Porótica (HP), Cribra orbitalia (CO) e Hipoplasia Linear de Esmalte (HLE) em 35 indivíduos de Içara-01 e seusresultados foram comparados com os adquiridos para indivíduos sepultados em períodos concomitantes dos sambaquis Cabeçuda e Jabuticabeira II. As autoras levantam a hipótese de que os indivíduos sepultados em Içara poderiam ser de um grupo litorâneo que utilizou o sítio como cemitério e que teria mobilidade na costa e no planalto, e não provenientes do planalto e que utilizariam Içara comoacampamento temporário, como postula a literatura. Abstract: As part of a research project that aimed to investigate the osteological markers behavior in human remains from a long-term perspective on the south coast ofSanta Catarina (Brazil), interesting results were obtained from the Içara´s conchiferous site (Içara-01). The authors analyzed osteological stress markers of Porotic Hyperostosis (HP), Cribra orbitalia (CO) and Linear Enamel Hypoplasia(LEH) in 35 individuals from Içara-01. They compared the results with those obtained for individuals buried in concomitant periods at Cabeçuda and Jabuticabeira II shellmounds. The hypothesis is that the buried individualsin Içara-01 could be members from a coastal group that used the site as a cemetery and had mobility through the coast and the highland, and not that came from the highland and used Içara-01 as a temporary camp, as the literature postulates.
A Área de Saúde da Mulher Negra: Considerações sobre Racismo Institucional
Authors: Santos Sônia Beatriz dos 
Published: July 2019

O artigo discute a área de saúde da mulher negra como uma estratégia e abordagem que se contrapõe ao racismo presente nas instituições de assistência a saúde, e que têm afetado diretamente as mulheres negras (e a população negra num sentido mais amplo). A organização da área é parte de um movimento alavancado por ativistas e profissionais negras(os) e suas organizações como um campo de conhecimento e intervenção social e política que propunha em meados do século XX, um novo modelo fundado numa perspectiva racial e de gênero, para pensar e atuar na assistência em saúde, demandar o direito à saúde da mulheres, e denunciar o racismo no sistema de saúde. Abstract: The article discusses the area of Black women's health as a strategy and approach that opposes institutional racism in health care institutions, which have directly affected Black women (and the Black population in a broader sense). The organization of the area was part of a movement leveraged by Black activists and health professionals, and their organizations as a field of knowledge and social and political intervention that proposed in the mid-twentieth century a new model based on a racial and gender perspective to think and act in health care, to demand the women’s right to health, and denounce racism in the health system.
A arte do “acolhimento”: novas perspectivas sobre a salvaguarda do jongo
Authors: Cunha João Alipio De Oliveira 
Published: July 2019

Esse artigo é um desdobramento da pesquisa realizada entre os anos de 2016 e 2018 sobre a Casa do Jongo de Pinheiral, conhecida por ser um lugar onde os jongueiros desenvolvem praticamente todas as suas atividades – apresentações, projetos educacionais, turismo comunitário, festas religiosas e de lazer – mas é, principalmente, considerado por eles o “lugar do acolhimento”. O “lugar do acolhimento” tem sido na prática onde os jongueiros realizam a salvaguarda da cultura e deles próprios. Assim, pretendo através desse texto pensar a prática da salvaguarda do Jongo através dos jongueiros e suas múltiplas conexões com a história, a religião, a Casa do Jongo e o “território jongueiro”. Na primeira parte do texto faço uma análise do trabalho de campo realizado junto ao Grupo Jongo de Pinheiral e analiso a categoria “território jongueiro”, em conexão com seus saberes e relações com a própria história do jongo. Num segundo momento descrevo o processo de patrimonialização e salvaguarda do jongo que em diferentes situações os jongueiros foram protagonistas. Na última parte faço um relato de como a Casa do Jongo tem sido fundamental para concretização da salvaguarda do Jongo num ambiente de descaso e ausência de políticas públicas sérias para os jongueiros. Abstract: This article is a result of the research carried out between 2016 and 2018 on the Casa do Jongo de Pinheiral, known as a place where jinguiros develop practically all their activities - presentations, educational projects, community tourism, religious and leisure parties - but is mainly considered by them as the "lugar do acolhimento" where they carry out the safeguarding of culture and of themselves. In the first part of the text I make an analysis of the fieldwork carried out with the Jongo de Pinheiral Group and analyze the category "jongueiro territory", in connection with its knowledge and relations with the history of jongo. In a second moment I describe the process of patrimonialization and safeguard of the jongo that in different situations the jongueiros were protagonists. In the last part I make an account of how the Casa do Jongo has been fundamental for the realization of the safeguard of intangible heritage in an environment of neglect and absence of serious public policies for jongueiros.
Measurement of urinary 5-HIAA: correlation between spot versus 24-h urine collection
Authors: Calanchini Matilde , Tadman Michael , Krogh Jesper , Fabbri Andrea , Grossman Ashley , Shine Brian 
Published: July 2019

Background
The 24-h urinary output of 5-hydroxyindoleacetic acid (5-HIAA) is used to monitor disease progression and treatment responses of neuroendocrine neoplasms (NENs). Several conditions are required for 5-HIAA assay, involving urine collection/preservation and food/drug restrictions.

Aim
To evaluate the correlation between 5-HIAA concentration in a spot urine sample and the output in a 24-h urine collection, and whether spot urine specimens can replace 24-h collection.

Methods
Patients with NENs or symptoms suggestive of NENs were asked to provide a separate spot urine at the end of the 24-h urine collection for 5-HIAA assessment. The upper reference limit for 24-h urinary 5-HIAA was 40 µmol/24 h. 5-HIAA measurements in spot urine samples were corrected for variation in urine flow rate by expressing results as a ratio to creatinine concentration.

Results
We included 136 paired urinary samples for 5-HIAA assessment from 111 patients (100 NENs). The correlation between 5-HIAA values measured in 24-h and spot urines was r = +0.863 (P < 0.001) and r = +0.840 (P < 0.001) including only NEN patients. Using the 24-h urinary 5-HIAA as reference method, the AUC on ROC analysis for spot urinary 5-HIAA was 0.948 (95% CI, 0.914–0.983; P < 0.001), attaining a sensitivity of 83% and specificity of 95% using 5.3 mol/mmol as cut-off for the spot urine. The AUC among NEN patients alone was 0.945 (95% CI, 0.904–0.987; P < 0.001).

Conclusions
The ratio of 5-HIAA to creatinine in a spot urine could replace the measurement of 5-HIAA output in a 24-h urine collection, especially for follow-up of patients with known elevated 5-HIAA levels.
Associations of circulating chemerin and adiponectin concentrations with hepatic steatosis
Authors: Levin Lena-Maria , Völzke Henry , Lerch Markus M , Kühn Jens-Peter , Nauck Matthias , Friedrich Nele , Zylla Stephanie 
Published: July 2019

Objective
Chemerin and adiponectin are adipokines assumed to be involved in the development of metabolic syndrome-related phenotypes like hepatic steatosis. We aimed to evaluate the associations of circulating chemerin and adiponectin concentrations with liver enzymes, liver fat content, and hepatic steatosis in the general population.

Methods
Data of 3951 subjects from the population-based Study of Health in Pomerania (SHIP-TREND) were used. Hepatic steatosis was assumed when either a hyperechogenic liver (assessed via ultrasound) or a magnetic resonance imaging (MRI)-quantified liver fat content >5% was present. Adjusted sex-specific quantile and logistic regression models were applied to analyze the associations of chemerin and adiponectin with liver enzymes, liver fat content and hepatic steatosis.

Results
The observed associations of chemerin and adiponectin with liver enzymes were very divergent depending on sex, fasting status and the specific enzyme. More consistent results were seen in the analyses of these adipokines in relation to MRI-quantified liver fat content. Here, we observed inverse associations to adiponectin in both sexes as well as a positive (men) or U-shaped (women) association to chemerin. Similarly, the MRI-based definition of hepatic steatosis revealed strongly consistent results: in both sexes, high chemerin concentrations were associated with higher odds of hepatic steatosis, whereas high adiponectin concentrations were associated with lower odds.

Conclusion
Our results suggest a role of these adipokines in the pathogenesis of hepatic steatosis independent of metabolic or inflammatory disorders. However, experimental studies are needed to further clarify the underlying mechanisms and the inter-play between adipokine concentrations and hepatic steatosis.
THEORETICAL AND PRACTICAL VALUE OF THE REVIEWS ON UKRAINIAN TERMINOLOGY DICTIONARIES OF THE LATE XXth AND THE EARLY XXIst CENTURIES
Authors: Petrova Tetiana 
Published: July 2019

The aim of the research is to determine the theoretical and practical significance of the reviews on natural sciences terminology dictionaries. The object of the research is a system of parametric measurements of terminology dictionaries, the subject is critical remarks on the structural parameters representation of terminology dictionaries. The research material is the texts of the reviews published during the late XXth and the early XXIst centuries. Тhe following methods were used: lexicographic analysis of the dictionary parameters, the quantitative analysis and the comparative one. As a result of the research, it is determined that throughout the analyzed period the experts focus on definition and translation dictionaries as well as reference dictionaries. Most remarks are made to the dictionaries of the early XXIst century. The potential importance of practical application of the results is to improve the theoretical and methodological principles and means of terminology dictionaries creation, as well as their use to develop new (combined) type that comprehensively represent the vocabulary of a particular branch of science. Conclusions: 1) the critical comments on professional definition dictionaries relate to such of their parameters as: ‘introduction / preface’, ‘encyclopedia information’, ‘dictionary register’, ‘definition’, ‘list of references’; 2) translation definition dictionaries have quantitative drawbacks regarding the representation of such structural parameters: ‘dictionary register’, ‘translation area’, ‘definition’; 3) to the parameters of reference dictionaries the following critical comments are made: to replace the title loan term by the normative term; to add the ‘accent characteristic’ parameter; to match the title terms with their definitions etc. Theoretical and practical significance of the reviews on terminology dictionaries gives the possibility to systematize the drawbacks revealed by critics in the representation of structural parameters of such publications, for the purpose to improve the fundamental theoretical and methodological foundations of metaterminography and the practical realization of high-quality works.
Guerra Vilaboy, Sergio, y Roberto González Arana. 2017. Dictaduras del Caribe. Estudio comparado de las tiranías de Juan Vicente Gómez, Gerardo Machado, Fulgencio Batista, Leónidas Trujillo, Los Somoza y los Duvalier
Authors: Acuña Noguera Aneth Cristina 
Published: July 2019

El libro Dictaduras del Caribe, hace un estudio comparativo de Cuba, Venezuela, Haití, República Dominicana y Nicaragua pues éstos países tienen en común, el haber sido -a través de las figuras representativas de Gómez, Machado, Batista, Trujillo, Somoza y Duvalier- aliados de Estados Unidos a través del corolario Roosevelt a la doctrina Monroe. Dicha política norteamericana se basó más que todo en afianzar el poderío militar y económico de éste país angloparlante, hacía América Latina, para frenar la injerencia de los paises europeos en tierras americanas hacía finales del siglo XIX y principios del siglo XX. Estados Unidos para detener la intromisión de los países europeos en América Latina, se basó en todo tipo de métodos colonialistas con las más modernas formas de penetración del capitalismo para dicho fin.
Use of radio telemetry to determine presence of cattle stress indicators before slaughter
Authors: Paz-Penagos Hernan 
Published: July 2019

This study was conducted in order to determine the presence of stress in cattle prior to slaughter in situations such as loading, trans-porting, unloading, water and food deprivation during mobilization and waiting in the corral in overcrowded and inclement condi-tions. Samples were five bovines with ages of 40 months on average, castrated males, from the San Martinero criolla breed, whichwere transported along 144 Km, by land, from the farm located in Acacias, department of Meta, to the ICTA slaughter plant in Bo-gotá. The stress indicators were identified by differences in body temperature, heart rate and respiration frequency (hereinafter-physiological constants), which were monitored for 20 minutes at the time: prior to loading the animals on the farm, and uponarri-val at the slaughterhouse (just after being transported). The bovine cardiac signal was captured and processed through a girth, and was transmitted via a radio telemetry system that was designed and built in the project. The results show data capture at a sample rate of four million samples per second and wireless communication in real time, which meant that no information was lost on thevariations of the bovine heart signal and reception of information from any point of the slaughter plant.
Evaluación del potencial biotecnológico de un promotor derivado del virus de la distorsión de la hoja de maracuyá (PLDV), un begomovirus que infecta maracuyá
Authors: Vaca-Vaca Juan Carlos , Carrasco-Lozano Emerson Clovis , Lopez-Lopez Karina 
Published: July 2019

Los avances biotecnológicos en plantas requieren la bioprospección de nuevos promotores para la expresión de genes de interésagronómico, en particular, es necesario caracterizar nuevos promotores con expresión tejido específica. El objetivo de esta investi-gación fue evaluar la actividad de expresión del promotor del gen AV1que codifica para la proteína de la cápside (CP) del virus de la distorsión de la hoja de maracuyá (Passion fruit leaf distortion virus,PLDV) mediante ensayos transitorios de biobalística de baja presión. Se realizó un análisis de la región promotora del gen AV1empleando herramientas bioinformáticas. Se construyó una fu-sión traduccional (CP-PLDV-GUS), que porta la región promotora del gen AV1de PLDV fusionada al gen reportero uidA(GUS). CP-PLDV-GUS fue bombardeado sobre hojas de plántulas de tabaco cultivadas in vitro empleando una pistola de genes. Como control positivo se utilizó el plásmido pBI121 que porta el gen GUS bajo el control del promotor 35S de CaMV. Se llevaron a cabo 11 re-peticiones, donde la unidad experimental fue la hoja y la variable de respuesta, la expresión transitoria del gen GUS representado por el número de puntos azules observados en las hojas bombardeadas. Como resultado, el análisis estadístico no paramétrico demostró que existe evidencia muestral suficiente para confirmar que, tanto el promotor AV1del PLDV y 35S de CaMV presentan una actividad de expresión semejante. Finalmente, el promotor del gen AV1de PLDV mostró una fuerte actividad de expresión del gen reportero en las células del mesófilo de las hojas, el cual podría ser usado para conferir expresión tejido específica enplantas transgénicas