bluuebunny/crossref_metadata_2025_split huggingface dataset:
Molecular and In Silico Analysis of the CHEK2 Gene in Individuals with High Risk of Cancer Predisposition from Türkiye
Authors: Ozdemir Ozkan , Bychkovsky Brittany L. , Unal Busra , Onder Gizem , Amanvermez Ufuk , Aydin Eylul , Ergun Berk , Sahin Ilayda , Gokbayrak Merve , Ugurtas Cansu , Koroglu Merve Nur , Cakir Berfin , Kalay Irem , Cine Naci , Ozbek Ugur , Rana Huma Q. , Hatirnaz Ng Ozden , Agaoglu Nihat Bugra 
Published: November 2024

Background and Objectives: Checkpoint kinase 2 (CHEK2) is a tumor suppressor gene involved in DNA repair and cell cycle regulation. Pathogenic or likely pathogenic (P/LP) variants in CHEK2 are associated with increased cancer risk. Conversely, recent large cohort studies have identified certain variants that, despite being classified as P/LP by in silico analysis, are considered low risk. Thus, the genotype–phenotype correlations of CHEK2 require a better understanding. In this study, we aimed to characterize germline CHEK2 variants from a group of individuals who applied to cancer genetic clinics in the Marmara Region of Türkiye. We also aimed to assess the phenotypic impacts of these variants by using a new score of statistically significant in silico predictors (SSIPs). Methods: We analyzed 1707 individuals with high risk cancer predisposition, focusing on germline CHEK2 variants, using SSIP scores and population-specific data. Results:CHEK2 variants appeared in approximately 8% of cases. The SSIP scores indicated that the missense mutation, p.Arg117Gly, significantly impairs DNA repair. Almost half of the variants had higher allele frequencies than the variants listed in the Genome Aggregation Database (gnomAD), and three variants had significantly higher frequencies compared to the variants listed on the Turkish Variome database (p.Thr476Met, p.Arg137Gln, c.592+3A>T), emphasizing the importance of population-specific data. Conclusions: This comprehensive analysis of CHEK2 variants in the Turkish population provides crucial insights for cancer geneticists and oncologists. Our findings will help to enhance the evaluation and management of cancer predisposition associated with CHEK2 in Türkiye and other regions that have significant Turkish populations.
Discussing poverty within primary-care consultations: implications for mental health support
Authors: Thomas Felicity , Wyatt Katrina , Berzins Kathryn , Lee Ilse , Horrell Jane , McLoughlin Alison 
Published: November 2024

BackgroundPoverty can have significant impacts on health and wellbeing. However, asking patients about their broader socio-economic circumstances is not routine within primary care consultations.AimTo understand healthcare professionals’ experiences of communicating with patients about their socio-economic circumstances and how a bespoke training programme supported these conversations in routine consultations.Design & settingHealthcare professionals from 30 GP practices across England received training to improve understanding and communication with patients about the ways that poverty impacted their mental health.MethodSemi-structured interviews were undertaken with 49 GPs and allied health professionals to understand barriers and enablers to communication around poverty and the impact of the training on their consultation practice.ResultsHealth professionals often lacked confidence in discussing socio-economic issues and welcomed information on how to do this sensitively. Asking questions relating to poverty-related stresses was felt to lead to better understanding around the causes of mental distress, avoidance of problematic assumptions and inappropriate antidepressant prescribing and to enable more coordinated and appropriate support from practice teams.ConclusionAsking patients about their socio-economic circumstances can facilitate provision of appropriate support.
The influence of mineralogical composition and alkali reactivity for utilization of some Egyptian crushed granites as a concrete aggregate
Authors: El-fakharany Maged , Omar Ahmed , Abdellatif Mahmoud 
Published: November 2024

Egyptian Eastern Desert is rich in many areas that contain granites masses throughout the geological era; some of them show good characteristics of the rock hardness, durability, density and mineralogy. This current research aims to utilize three main types of granite aggregates based on their mineralogical composition and Alkali reactivity with cement during concrete production. The studied granite aggregate can be also classified into red younger granite aggregate, white older granite aggregate and grey older granite aggregate. Evaluating these granite rocks as aggregate used in concrete mixture is interesting by produced three mixes using the three studied granite aggregate symbolized (Red GA), (White GA) and (Grey GA), tested mechanically to give a more detailed for the obtained results to be not restricted for only studied granite aggregate criteria but also to follow the actual reaction of this studied granite aggregate with cement. It was obtained that all studied granite aggregates within acceptable limits of concrete aggregate by following Egyptian code (ECP-203) although their variation on its mineralogical composition. Some reflections produced from change in mineralogical composition between the three studied granite aggregates exhibited by relative regression in the average physico-mechanical values for both (White and Grey GA) than (Red GA). On the other hand, slight reactive for (Red GA) than others at the age of 28 day. In addition, all produced (Red GA), (White GA) and (Grey GA) mixes were acceptable mechanically with limits of (ECP-203) giving benefit for using all of the studied granite aggregate after their detailed study involving its mineralogical composition and alkali aggregate reactivity (AAR).
The Application of UNCITRAL Model Law on Electronic Transferable Records in Kuwait: A Comparative Study
Authors: Alawneh Tariq Shafiq 
Published: November 2024

The existing requirements in national and international law for the use of written documents or manual signatures in international trade transactions are considered to constitute major obstacles to the development of electronic commerce at global level. Other obstacles also include questions and uncertainties concerning the validity, legal effect and enforceability of transactions regarding electronic bill of lading conducted via electronic means, in a legal environment based on paper. The Law No 20/2014 excluded promissory notes and negotiable bills of exchange from the scope of application of this law. The law also does not apply to any event that the law requires to be expressed in a written document or to be documented or when it is subject to a specific provision in another law, e.g. the bill of lading where the Kuwaiti Maritime Law states that the maritime contract of carriage shall be made in a form of bill of lading, and shall be written. The law says that the bill of lading shall be drawn on two originals; one shall be handed over to the shipper and the other to the carrier and shall be stamped by a non-negotiable seal. This research aims to investigate the applicability of negotiable electronic instruments and documents (mainly the bill of lading) in Kuwait. The research shall examine whether the Kuwaiti Law No 20/2014 should be Expanded to Include Transferable Instruments. The research analysed the three jurisdictions (Bahrain, Singapore, and Abu Dhabi Global Market, and compared them with the Kuwaiti law in terms of adopting the Model Law on Electronic Transferable Records.
Keywords: Commercial law, Electronic commercial law, Electronic transferable records, Bill of lading, Negotiable instruments.
Caracterización clínica de pacientes con insuficiencia cardiaca aguda
Authors: Ramírez Contreras Rocío Betzaida 
Published: November 2024

Clinical characterizacion of patients with acute heart failure
OBJETIVO: Describir las características clínicas de los pacientes con insuficiencia cardiaca aguda que fueron atendidos en el Hospital Nacional Nicolasa Cruz de Jalapa de enero 2019 a diciembre 2023. MÉTODOS: Se realizó un estudio descriptivo retrospectivo, donde se evaluaron 115 expedientes clínicos utilizando una boleta de recolección de datos que se aplicó a cada expediente. RESULTADOS: Entre las características clínicas, el grupo etario más afectado fue entre la edad de 60 a 70 años en un 43%, el sexo fue femenino en un 60%, como síntoma principal destaca disnea con un 30.48%, el signo más común fue subcrepitantes pulmonares con 59.1% y el signo vital fue frecuencia respiratoria elevada con 63%. Con respecto a clasificación de Stevenson el 57% fueron grado B, según la escala NYHA el 38% se clasificaron grado III, según la FEVI un 33.29% tienen función conservada y la hipertensión arterial es la comorbilidad mas frecuente en un 77.4%. CONCLUSIONES: Se resalta que los pacientes con insuficiencia cardíaca son predominantemente mujeres y personas mayores, con hipertensión y diabetes como las comorbilidades más comunes. Los signos vitales y síntomas reflejan la severidad de la enfermedad, siendo la disnea y los subcrepitantes pulmonares los síntomas y signos más característicos.
Pembuatan lip balm nanoekstrak umbi bit (Beta vulgaris L.) dan bunga rosella (Hibiscus sabdariffa L.) sebagai pelembab alami
Authors: Jannah Miftahul , Dalimunthe Gabena Indrayani , Lubis Minda Sari , Rani Zulmai 
Published: November 2024

Salah satu bagian kulit terluar yang paling sensitif pada wajah adalah bibir karena rentan terhadap cuaca ekstrem seperti panas dan dingin yang dapat menyebabkan kekeringan dan pecah-pecah. Untuk mengatasi kondisi tersebut, sangat penting menggunakan sediaan lip balm. Salah satu tumbuhan yang digunakan sebagai bahan aktif pada sediaan lip balm yaitu umbi bit dan bunga rosella. Kosmetik berbasis nanopartikel memiliki keunggulan dibandingkan kosmetik skala mikro. Penelitian ini bertujuan untuk mengetahui nanoekstrak umbi bit dan bunga rosella dapat diformulasikan dalam bentuk sediaan (lip balm) dan untuk mengetahui ekstrak umbi bit dan bunga rosella memenuhi persyaratan karakteristik sebagai nanoekstrak dan ntuk mengetahui sediaan pelembab bibir (lip balm) dari umbi bit dan bunga rosella dapat digunakan sebagai pelembab. Metode penelitian ini adalah metode True Eksperimental dan dengan rancangan pnelitian yang digunakan adalah Post Test Control Grup Design dimana hasil telah diamati setelah perlakuan selesai. Penelitian ini manggunakan sampel umbi bit dan bunga rosell. Tahapan pada penelitian ini meliputi penyajian sampel, karakterisasi simplisia, skrining fitokimia, pembuatan ekstrak dan nanoekstrak, formulasi pelembab bibir (lip balm), evaluasi mutu fisik dan uji kelembaban. Hasil penelitian menunjukan bahwa umbi bit dan bunga roella mengandung senyawa alkaloid, flavanoid, saponin, tanin dan antosianin. Nanoesktrak umbi bit dan bunga rosella memenuhi karakteristik sebagai nanoekstrak dengan ukuran partikel untuk umbi bit sebesar 261,64 nm dan bunga rosella sebesar 143,86 nm, Umbi bit dan Bunga rosella yang diformulasikan dalam bentuk sediaan pelembab bibir (lip balm) dapat melembabkan bibir dibuktikan dengan adanya peningkatan nilai persentase kadar kelembapan dan kadar minyak pada kulit bibir sebelum dan setelah pemakaian sediaan.
Trend Analysis of Admission, Enrolment, Completion, and Transition Rates in Primary Education in Ghana
Authors: Dwamena Quansah Joseph Yaw , Aboagye Dacosta , Alagbela Alaric A. 
Published: November 2024

The purpose of this study was to investigate trends in primary education admission, enrolment, completion rates, and transition rates to junior high school in the Bongo District from 2012 to 2021. A descriptive exploratory design was used. This study used secondary data from the Ghana Education Office of the Bongo District in the Upper East region of Ghana to analyse trends in access to and participation in primary education within the district during the period studied. Findings revealed that a significant number of children enrolled in primary education were not in the appropriate grade for their age; the majority were either below or above the age range of 6 to 11 years for primary education in Ghana. Additionally, the percentage of the out-of-school population within the appropriate age range for primary education (NER) increased by 1.1 percentage points, from 15.4% in 2012 to 16.5% in 2021. This study recommends community outreach programmes by the district education office to address sociocultural factors affecting pupils’ participation in primary education.

Received: 28 August 2024 / Accepted: 11 November 2024 / Published: 20 November 2024
Heritage Nation Educational and Vocational Paths
Authors: Papa Erinda 
Published: November 2024

The intake of immigrants and refugees by countries such as Canada, the US, the UK, and Australia has significant implications for involved adults and children. As they navigate their heritage nations, the acquisition of the English language becomes essential for education and vocational purposes. In essence, to be integrated into their heritage nations, migrant adults and children face the challenge of having to learn a second language. It is important to acknowledge the disruption of education and careers experienced by these individuals as they seek new beginnings in heritage nations. While heritage nations such as Canada have programs that facilitate the integration of immigrants and refugees, some of the initiatives fail to take into account their diverse needs. For example, Fang et al. (2018) indicate that refugees face gendered barriers, low education levels, emotional scars and physical impairments, and cultural barriers, which hinder their acquisition of the English language. Understanding the specific challenges immigrants and refugees face as they transition to their new environment is critical to improving their experience. This paper examines the psychological, socio-cultural, and educational implications of education and career disruptions of immigrants and refugees and suggests strategies to support new language acquisition.

Received: 30 September 2024 / Accepted: 2 November 2024 / Published: 20 November 2024
India's Industrial Revolution: Navigating Job-Oriented Growth Amidst Global Geopolitical Realities
Authors: Prabhakar Akhilesh Chandra 
Published: November 2024

This study probes India’s industrial revolution, centering on a job-driven growth model within the nuanced framework of global geopolitical dynamics. Despite over seven decades of independence, India continues to face profound challenges in realizing comprehensive industrial and agricultural revolutions, marked by rising unemployment, widening income inequality, and a growing reliance on private corporate entities. Drawing upon recent reports and economic data, this analysis examines key impediments to India’s growth, including its significant dependence on energy imports, the widening wealth gap, and a rising public debt burden. India’s evolving geopolitical posture plays a dual role: strengthening alliances with the United States, Europe, and Japan while consolidating its leadership within the Global South. The study further investigates India’s diplomatic balancing act in navigating strategic relationships with China and Russia amid a rapidly changing global landscape. Ultimately, this paper emphasizes the necessity of a sustainable industrial strategy rooted in workforce development, innovation, and economic self-reliance, aiming to position India to navigate its complex role on the international stage while fostering inclusive growth domestically.

Received: 12 September 2024 / Accepted: 8 November 2024 / Published: 20 November 2024
Effectiveness of Dialectical Behaviour and Schema-Focused Therapies in the Management of Depressive Disorders among In-School Adolescents in Edo State
Authors: Adubale Andrew A. , Tokurah Ayotunde Eghogho 
Published: November 2024

The study investigated the effectiveness of Dialectical Behaviour and Schema-Focused Therapies in managing depressive disorders in in-school adolescents in Benin Metropolis. The study was a quasi-experimental research design that adopted the pre-test-post-test, non-equivalent control group. The population for this study consisted 14,473 senior secondary school students in all the public secondary schools in Benin Metropolis. A sample size of seventy-six (76) adolescents was used. The instrument for the study was Adolescent Depressive Disorder Questionnaire (ADDQ). Three (3) research questions were raised, their corresponding hypotheses were formulated and tested at 0.05 alpha level of significance. The data obtained were analyzed using t-test and Analysis of Variance (ANOVA). The findings of the study revealed no significant effect of both Dialectical Behaviour and Schema-Focused Therapies in managing depressive disorders in in-school adolescents. However, there was a significant effect of Dialectical Behaviour on the depressive disorders of in-school adolescents than those not exposed to any treatment (Control Group). It was concluded that although both Dialectical Behaviour and Schema-Focused Therapies were not statistically significant in managing depressive disorders in in-school adolescents in Benin Metropolis, there was a difference in the depressive disorders mean scores at pre-test and post-test.

Received: 2 September 2024 / Accepted: 3 November 2024 / Published: 20 November 2024
An Empirical Assessment of Pro-Poor Growth in Moroccan Regions: Inclusion of Intra-Regional Inequalities
Authors: Errahmani Ahlam , Aziz Bensbahou 
Published: November 2024

Aware of the issues linked to inequality and growth and their implications for poverty, our article aims to empirically assess the “poverty-growth-inequality” triangle at the level of Morocco's 12 regions over the period 2001 to 2014. The approach adopted is based on the decomposition methods of Kakwani and Prenia, making it possible to measure the total elasticity of poverty to growth and inequality, and then to quantify pro-poor growth and pro-poor policy indices by region. As such, the contribution of this work is to introduce income inequalities within regions instead of total inequalities in the understanding of spatial inequality policies affecting regional poverty and growth. These inequalities are calculated using Dagum's (1989) decomposition and incorporated into the estimated models. The main results of our study confirm the presence of significant and differentiated effects of inequality and growth on regional poverty reduction, with a greater effect of inequality.

Received: 15 September 2024 / Accepted: 5 November 2024 / Published: 20 November 2024
Collocations in Methods Section of Masters of English Language Theses
Authors: Davi Wilhelmina Coker , Asafo-Adjei Ramos , Bukari Francis 
Published: November 2024

Collocation has long been recognised as a problematic domain for Second language learners of English and acknowledged to lag far behind the acquisition of other Second language acquisition (SLA) aspects. This mixed approach study was, therefore, aimed to identify content words and their collocations in the methods section of the Master of Philosophy in English Language theses. Specifically, the research question was: What are the collocations of the content word in the Methods sections of English language MPhil theses at the University of Cape Coast, Ghana? The data was purposively sampled from 20 MPhil theses submitted to the Department of English and analysed using AntConc 3.5.8 software. The Firthian (1986) Collocation Approach was used for the study. The findings showed that the content word data is the keyword typical of the methods section, and it strongly collocates with both nouns and verbs to both the left and to the right in varied ways. Also, near-synonyms collocate differently with the keyword data. This study makes a vital contribution by revealing how the students in the Master of Philosophy in English programme make use of language to present the methods section of their theses. The study offers implications for engendering students’ academic writing, especially at the postgraduate level.

Received: 18 September 2024 / Accepted: 10 November 2024 / Published: 20 November 2024
God-free energy and evolutionary epistemology
Authors: Van Rooyen Johan A. 
Published: November 2024

This article investigates the reasons behind interwovenness and the profound philosophical thought that a God must be a part of the brain’s predictive processing entropies. The article accomplishes this by utilising South African theologian Wentzel J. van Huyssteen’s epistemological consciousness as an added benefit in examining our planet and, as a result, our cosmic universe, which transcends human God notions. This article caters for academics interested in the science-religion dispute on the existence of life inside the integrated metaphysical God. In this article, the connection between metaphysicality, free energy and Van Huyssteen’s epistemic consciousness is used as metaphor(s) in our estimates of what life is, which includes a God, as it will show that we as humans can reasonably expect to exist beyond this (the) Earth. It is therefore the primary question that resonates with the whole of the universe as well as the minute fragmentation that is humans, only recently identified as sapiens, that sigh, or even better, long for a God, that encloses the question of: are we as humans made of, organs, metabolic systems, cells, atoms, memories or passions, that are a plausible mixture of an effective cognitive and affective cocktail, so to speak?Intradisciplinary and/or interdisciplinary implications: This article proposes a dual paradox that theology and science are not only in opposition yet are, juxtaposing (therefore integrating) one another. They share a very astute understanding of free energy from both a mathematical (natural sciences) and philosophical (theological) evolutionary epistemological perspective.
Corona mortis—A south Indian cadaveric study
Authors: Sengodan Vetrivel Chezian , Sivagnanam Marimuthu , Selvaraj Ranjithkumar , Rathinasamy Surendhar 
Published: November 2024

BACKGROUND:
“Corona mortis” is an abnormal arterial or venous connection between the obturator and the inferior epigastric or external iliac arteries or veins, which can cause torrential bleeding leading to the death of the individual. It may be encountered during acetabular surgeries, hernia surgeries, and gynecological procedures. The purpose of our study is to determine the incidence and variations of corona mortis in the south Indian population.

MATERIALS AND METHODS:
Forty hemipelves of 20 cadavers were in our study group. With the cadaver in the supine position, dissection was done using Stoppa’s approach. After dissection, data about the presence or absence of corona mortis, the nature of corona mortis (arterial/venous/arteriovenous variant), and the distance between corona mortis and pubic symphysis were collected.

RESULTS:
Corona mortis was present in 33 (82.5%) hemipelves. It was bilateral in 13 (65%) cadavers. It was present in all the female cadavers on both sides, whereas it was present in 21 (75%) out of the 28 male hemipelves. Venous variant was present in 26 (78.78%), followed by arteriovenous variant in five (15.16%), and arterial variant in two (6.06%) hemipelves. The mean distance of corona mortis from pubic symphysis was 55.65 mm.

CONCLUSIONS:
The incidence of corona mortis was 82.5% in our study. Our study was dominated by the venous variant compared with the arterial and arteriovenous variants. Corona mortis had gender variations: it was present in all the females in our study, whereas it was not so among males as per our study.