bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association of work-related and leisure-time physical activity with workplace food purchases, dietary quality, and health of hospital employees
Authors: Feig Emily , Levy Douglas E. , McCurley Jessica L. , Rimm Eric B. , Anderson Emma M. , Gelsomin Emily , Thorndike Anne N. 
Published: July 2019

Abstract
Background

While leisure-time physical activity (PA) has been associated with reduced risk of cardiometabolic disease, less is known about the relationship between work-related PA and health. Work-related PA is often not a chosen behavior and may be associated with lower socioeconomic status and less control over job-related activities. This study examined whether high work-related PA and leisure-time PA reported by hospital employees were associated with healthier dietary intake and reductions in cardiometabolic risk.

Methods

This was a cross-sectional analysis of baseline data collected from 602 hospital employees who used workplace cafeterias and enrolled in a health promotion study between 2016-2018. Participants completed the International Physical Activity Questionnaire and two 24-hour dietary recalls used to calculate Healthy Eating Index (HEI) scores. A Healthy Purchasing Score was calculated based on healthfulness of workplace food/beverage purchases. Weight, blood pressure, HbA1c, and lipids were measured. Regression analyses examined Healthy Purchasing Score, HEI, and obesity, hypertension, hyperlipidemia, and diabetes/prediabetes by quartile of work-related PA, leisure-time PA, and sedentary time.

Results

The mean age of participants was 43.6 years (SD = 12.2), 79.4% were female, and 81.1% were white. In total, 30.3% had obesity, 20.6% had hypertension, 26.6% had prediabetes/diabetes, and 32.1% had hyperlipidemia. Median leisure-time PA was 12.0 (IQR: 3.3, 28.0) and median work-related PA was 14.0 (IQR: 0.0, 51.1) MET-hours/week. Higher leisure-time PA was associated with higher workplace Healthy Purchasing Score and HEI (p’s < 0.01) and lower prevalence of obesity, diabetes/prediabetes, and hyperlipidemia (p’s < 0.05). Work-related PA was not associated with Healthy Purchasing Score, HEI, or cardiometabolic risk factors. Increased sedentary time was associated with lower HEI (p = 0.02) but was not associated with the workplace Healthy Purchasing Score.

Conclusions

Employees with high work-related PA did not have associated reductions in cardiometabolic risk or have healthier dietary intake as did employees reporting high leisure-time PA. Workplace wellness programs should promote leisure-time PA and healthy food choices for all employees, but programs may need to be customized and made more accessible to meet the unique needs of employees who are physically active at work.
Mortality of preterm neonates and its predictors in the Northwest part of Ethiopia: A retrospective cohort study
Authors: Sinshaw Aklilu Endalamaw , Minuye Biniam , Mengistie Bezatu , Yeshambel Abebaw , Assefa Nega 
Published: July 2019

Abstract
Abstract
Background: Preterm birth is highly reported in some countries and disparities on survival rates of preterm neonate are escalating across countries. Providing adequate medical care during pregnancy and childbirth has been endorsed. However, neonatal mortality is continuing to be one of the sustainable development goals. To achieve this aim, data from the different geographical area is suggested.
Objective: This study was aimed to assess mortality of preterm neonates and its predictors in the Northwest part of Ethiopia.
Methods: Institution based retrospective cohort study was conducted among 535 preterm neonates. Data was entered into EPi-data 4.2.0.0 and transferred to STATA version 14 statistical software for analysis. Kaplan-Meier survival analysis and Log-rank test were used to see statistical differences between categories of variables. Cox proportional hazard model was used to identify independent predictors of preterm neonatal mortality. The proportional assumption test had been checked using the Schoenfeld residual test. Variables with p-value ≤ 0.05 were considered as predictors of preterm neonatal mortality.
Results: In this study, 31.2% (95% CI: 27.3, 35.1) of preterm neonate were died. Preterm neonates with a gestational age of less than 32 weeks (AHR=1.74; 95%CI: 1.24, 2.46), being male sex (AHR=1.38; 95%CI: 1.01, 1.90), born from preeclampsia/ eclampsia mothers (AHR=1.95; 95%CI: 1.13, 3.36), being extremely very low birth weight (AHR=2.94; 95%CI: 1.05, 8.24), diagnosed with respiratory distress syndrome (AHR=1.70; 95%CI: 1.20, 2.41) were predictors of preterm death.
Conclusion and Recommendations: Preterm neonatal mortality found to be high. Four neonatal and one maternal-related variable were recognized predictors of mortality in preterm neonates. The study suggests preventing and controlling preeclampsia/ eclampsia, especial care for neonates born with very low birth weight, born before 32 weeks of gestation, and diagnosed with respiratory distress syndrome are imperative.
Keywords: Preterm, Neonate, Mortality, Ethiopia
Prestroke statins use reduces oxidized low density lipoprotein level and improves clinical outcomes in patients with atrial fibrillation related acute ischemic stroke
Authors: he lanying , Xu Ronghua , Wang Jian , Zhang LIli , Zhang Lijuan , Zhao Wang , Dong Weiwei 
Published: July 2019

Abstract
Background

Atrial fibrillation (AF) is a common cause of cerebral infarction, which could lead to endothelial dysfunction, increased reactive oxygen species (ROS) and oxidized low density lipoprotein (Ox-LDL).AF is associated with higher mortality and more severe neurologic disability. Statins may exert neuroprotective effects that are independent of LDL-C lowering. The purpose of our study was to investigate whether prestroke statins use could reduce plasma Ox-LDL level and improve clinical outcomes in patients with AF related acute ischemic stroke(AIS).

Methods

This was a multicenter consecutive trial that involved four medical centers, 242 AIS patients with AF were identified, who underwent a comprehensive clinical investigation and a 72h-Holter electrocardiogram monitoring. All patients were divided into two groups: prestroke statins use and no prestroke statins use groups, who were followed up for 3 months. Ox-LDL was measured using enzyme-linked immunosorbent assay (ELISA) on admission and 3 months. The outcome was death or major disability (modified Rankin Scale score≥3) at 3 months after AIS.

Results

Plasma Ox-LDL level was significantly lower in prestroke statins use than in no prestroke statins use on admission (P=0.001). Plasma Ox-LDL level on admission were associated with 3-month outcome(P<0.05).In fully adjusted models, prestroke statins use was associated with reduced 3-month mortality (adjusted odds ratio, 0.43; 95% confidence interval, 0.20–0.93; P=0.031), major disability (adjusted odds ratio, 0.33; 95% confidence interval, 0.13–0.82; P=0.017), and composite outcome (adjusted odds ratio, 0.25; 95% confidence interval,0.11–0.56; P=0.001).

Conclusions

Prestroke statins use can reduce plasma Ox-LDL level and improve clinical outcomes in patients with AF related AIS.
Silencing of Estrogen receptor β promotes the invasion and migration of osteosarcoma cells through activating Wnt signaling pathway
Authors: Zhang Yiping , Yin Changchang , Zhou Xufeng , Wu Yahua , Wang Lili 
Published: July 2019

Abstract
Background

This study aimed to evaluate the specific roles of Estrogen receptor β (ERβ) on the invasion and migration of osteosarcoma (OS) cells, and explore the regulatory mechanisms relating with Wnt signaling pathway.

Methods

The expression of ERβ was detected on human OS tissues by quantitative real-time PCR and immunohistochemistry. U2-OS cells were transfected with siRNA-ERβ (si-ERβ) to downrgulate ERβ, and treated with FH535 to inhibit Wnt signaling. The migration and invasion ability was detected by scratch and transwell assay, respectively. The expression of β-catenin, MMP-7 and MMP-9 was detected by Western blot. Subcutaneous tumor-bearing model was established by injection of U2-OS cells into mice, and the tumor volumes were measured. Orthotopic transplantation model was established by transplantation of tumor tissues into the liver of mice, and the metastatic tumors were counted.

Results

ERβ was downregulated in human OS tissues and U2-OS cells. The transfection of si-ERβ significantly increased the scratch healing rate, the number of invasion cells, and the expression of β-catenin, MMP-7 and MMP-9 in U2-OS cells. The injection of si-ERβ-transfected U2-OS cells into mice significantly increased the subcutaneous tumor volume, the expression of β-catenin, MMP-7 and MMP-9, and the number of metastatic tumors in liver tissues. The promoting effects of si-ERβ on the invasion and migration of U2-OS cells were significantly reversed by FH535 in vitro and vivo.

Conclusions

Silencing of ERβ promotes the invasion and migration of OS cells via activating Wnt signaling pathway.
Insecticidal Active Rotenoids from Plant Parts and Callus Culture of Medicago sativa L. from a Semiarid Region of India (Rajasthan)
Authors: Vats Sharad , Mehra Preeti 
Published: July 2019

Background:
Vector-borne diseases are quite prevalent globally and are one of the major
causes of deaths due to infectious diseases. There is an availability of synthetic insecticides, however,
their excessive and indiscriminate use have resulted in the emergence of resistant varieties of insects.
Thus, a search for novel biopesticide has become inevitable.

Methods:
Rotenoids were isolated and identified from different parts of Medicago sativa L. This group
of metabolites was also identified in the callus culture, and the rotenoid content was monitored during
subculturing for a period of 10 months. Enhancement of the rotenoid content was evaluated by feeding
precursors in a tissue culture medium.

Results:
Four rotenoids (elliptone, deguelin, rotenone and Dehydrorotenone) were identified, which
were confirmed using spectral and chromatographic techniques. The maximum rotenoid content was
found in the seeds (0.33±0.01%), followed by roots (0.31±0.01%) and minimum in the aerial parts
(0.20±0.05%). A gradual decrease in the rotenoid content was observed with the ageing of subcultured
tissue maintained for 10 months. The production of rotenoids was enhanced up to 2 folds in the callus
culture using amino acids, Phenylalanine and Methionine as precursors as compared to the control. The
LC50 value of the rotenoids was found to be 91 ppm and 162 ppm against disease vectors of malaria and
Dracunculiasis, respectively.

Conclusion:
The study projects M. sativa as a novel source of biopesticide against the disease vectors of
malaria and Dracunculiasis. The use of precursors to enhance the rotenoid content in vitro can be an
effective venture from a commercial point of view.
Novel Therapeutics Against Breast Cancer Stem Cells by Targeting Surface Markers and Signaling Pathways
Authors: Das Plabon K. , Rakib Md. A. , Khanam Jahan A. , Pillai Suja , Islam Farhadul 
Published: July 2019

Background:
Breast cancer remains to be one of the deadliest forms of cancers, owing to
the drug resistance and tumor relapse caused by breast cancer stem cells (BCSCs) despite notable advancements
in radio-chemotherapies.

Objective:
To find out novel therapeutics against breast cancer stem cells by aiming surface markers
and signaling pathways.

Methods:
A systematic literature search was conducted through various electronic databases including,
Pubmed, Scopus, Google scholar using the keywords "BCSCs, surface markers, signaling pathways
and therapeutic options against breast cancer stem cell. Articles selected for the purpose of this review
were reviewed and extensively analyzed.

Results:
Novel therapeutic strategies include targeting BCSCs surface markers and aberrantly activated
signaling pathways or targeting their components, which play critical roles in self-renewal and defense,
have been shown to be significantly effective against breast cancer. In this review, we represent a
number of ways against BCSCs surface markers and hyper-activated signaling pathways to target this
highly malicious entity of breast cancer more effectively in order to make a feasible and useful strategy
for successful breast cancer treatment. In addition, we discuss some characteristics of BCSCs in disease
progression and therapy resistance.

Conclusion:
BCSCs involved in cancer pathogenesis, therapy resistance and cancer recurrence. Thus,
it is suggested that a multi-dimensional therapeutic approach by targeting surface markers and aberrantly
activated signaling pathways of BCSCs alone or in combination with each other could really be
worthwhile in the treatment of breast cancer.
Rituximab Treatment Modulates the Release of Hydrogen Peroxide and the Production of Proinflammatory Cytokines by Monocyte at the Onset of Type 1 Diabetes
Authors: Hamouda Linda , Miliani Maroua , Hadjidj Zeyneb , Messali Rabia , Aribi Mourad 
Published: July 2019

Background:
Monocytes are the main blood innate mononuclear phagocyte and one of the
most important effector cells expressing Fcγ receptor, which is critical for the interaction with Fc domain
of antibodies.

Objective:
To evaluate the effect of Rituximab (RTX, a chimeric human anti-CD20 monoclonal antibody)
on the functional activities of Monocytes (MOs) at the onset of human Type 1 Diabetes (T1D).

Methods:
MOs were isolated from peripheral blood mononuclear cells (PBMCs) obtained from volunteer
patients with recent-onset T1D and healthy control donors.

Results:
The levels of the production of Interleukin 1β (IL-1β) and IL-6 were significantly increased in
MOs from patients with T1D when compared to MOs from healthy controls (respectively, p < 0.01 and
p < 0.05). Similarly, Interferon γ (IFN-γ), and intracellular free Calcium Ion (ifCa2+) levels were increased
in T1D MOs than in control MOs, but the difference did not reach a significant level. Conversely,
the production levels of IL-4 and catalase activity, as well as of both phagocytosis and killing
capacities were decreased in MOs of T1D patients compared to MOs from healthy controls, but the
difference was not significant for catalase activity and killing capacity (respectively, p < 0.01, p > 0.05,
p < 0.01, and p > 0.05). Additionally, treatment with RTX significantly upregulated phagocytosis (p <
0.05), markedly downregulated the release of IL-1β (p < 0.01), ifCa2+, hydrogen peroxide (H2O2), and
slightly downregulated the Nitric Oxide Synthase (NOS) activity, NOS activity-to-arginase activity
ratio, the levels of Lactate Dehydrogenase (LDH)-based cytotoxicity, and the production of IL-6 and
IFN-γ. Moreover, RTX treatment significantly upregulated the production of IL-4 (p < 0.05), IL-10
(p < 0.01) and the catalase activity (p < 0.05).

Conclusion:

Our study has shown for the first time that RTX can reverse the abnormal functional activities
of MOs as well as their production of proinflammatory cytokines at the onset of T1D. From a
therapeutic point of view, RTX may potentially be suggested at the beginning of T1D to immunomodulate
innate immunity and inflammatory conditions.
Model senam lansia untuk kebugaran jasmani dan fungsi otak
Authors: Putra Edo Fralian , Suharjana Suharjana 
Published: July 2019

Penelitian ini bertujuan untuk menghasilkan sebuah senam lansia untuk kebugaran jasmani dan fungsi otak. Metode penelitian ini mengacu pada penelitian Borg & Gall dengan tahapan: studi pendahuluan, analisis desain draf awal, validasi ahli, uji coba produk, evaluasi, dan revisi. Subjek uji coba skala kecil 15 orang, subjek uji coba penelitian skala besar 57 orang, dan subjek uji efektifitas produk 12 orang. Penilaian para ahli dan instruktur menggunakan kuisioner. Pengukuran kebugaran jasmani lansia menggunakan tes uji jalan 6 menit, sedangkan untuk mengukur fungsi kognitif lansia menggunakan tes The Montreal Cognitif Assesment Indonesia (MoCA–Ina). Hasil penelitian menunjukkan, model senam lansia valid, serta layak dan efektif untuk kebugaran jasmani dan fungsi otak. Hasil validasi ahli kesehatan lansia dan akademisi sekaligus praktisi kesehatan termasuk “sangat baik” dengan rata-rata 81,87%. Kualitas produk hasil uji coba skala kecil “sangat baik” dengan rata-rata 86,25. Uji coba skala besar juga termasuk “sangat baik” dengan rata-rata 98,12%. Hasil uji efektifitas produk menunjukkan peningkatan kebugaran jasmani lansia 0,32 poin (hasil pretest 4,4092 dan hasil postest 4,7292). Hasil uji efektifitas menunjukkan peningkatan fungsi kognitif lansia dengan 1,72 poin, (hasil pretest 25,58 dan hasil posttest 27,33). A gymnastic older model for pphysical fitness and brain function AbstractThis study aimed to develop an elderly gymnastics model for physical fitness and brain function. This research was research and development which refered to Borg & Gall's research steps through preliminary study, initial draft design analysis, expert validation, product trial, evaluation, and revision. The subjects of the small-scale trial were 15 people, the subjects of the large-scale trials were 57 people, and the subjects of the product effectiveness test were 12 people. The assessment of experts and instructors used a questionnaire sheet. The measurement of elderly physical fitness used a 6-minute walk test, while measuring their cognitive function used the Montreal Cognitive Assessment Indonesia (MoCA-Ina) test. The results showed that the developed elderly gymnastics model for physical fitness and brain function was valid. The result of expert validation showed the model was "very good" with an average score of 81.87%. The quality of the product according to the small-scale test was "excellent" with an average score of 86.25%. Furthermore, based on the large-scale trials the product was "excellent" with an average score of 98.12%. The results of the effectiveness test showed an increase in physical fitness of the elderly by 0.32 points (the pretest score of 4.4092 to the result of postest score of 4.7292). The result of the effectiveness test showed improvement of cognitive function of elderly by 1,72 point (the pretest score of 25.58 to the result of posttest score of 27.33).
Peningkatan keyakinan diri dan hasil belajar guling depan melalui latihan imagery
Authors: Harimurti Rizki Sito 
Published: July 2019

Penelitian ini bertujuan untuk meningkatkan keyakinan diri dan hasil belajar guling depan pada siswa putri kelas X Madrasah Aliyah Sunan Pandanaran melalui integrasi latihan imagery pada pembelajaran Penjasorkes. Penelitian ini merupakan penelitian tindakan kelas (PTK) yang dilaksanakan dalam dua siklus. Setiap siklus terdiri empat tahapan yaitu: persiapan, pelaksanaan, observasi, dan refleksi. Analisis hasil penelitian dilakukan secara deskriptif kualitatif. Subjek penelitian ini adalah 25 siswa dari kelas X A Madrasah Aliyah Sunan Pandanaran. Tindakan yang dilakukan berupa integrasi latihan imagery dalam pembelajaran guling depan. Pengambilan data penelitian melalui tes unjuk kerja, observasi, dan angket skala keyakinan diri. Tes unjuk kerja dilakukan pada penilaian hasil belajar guling depan. Angket skala keyakinan diri untuk mengukur tingkat keyakinan diri siswa. Sedangkan observasi dilakukan selama pembelajaran berlangsung untuk mengetahui keterlaksanaan pembelajaran. Hasil penelitian menunjukkan bahwa melalui program latihan imagery yang diintegrasikan dalam pembelajaran, siswa mengalami peningkatan keyakinan diri dan hasil belajar pada materi guling depan. Improve self-efficacy and learning outcomes of the forward roll through the exercise imagery AbstractThis research aims to improve self-efficacy and learning outcomes in the forward roll of female students of class X Madrasah Aliyah Sunan Pandanaran through the integration of imagery exercise in teaching Physical Education. This research is a classroom action research (CAR) conducted in two cycles. Each cycle comprised four stages: preparation, execution, observation, and reflection. The analysis of the results of research was conducted by qualitative descriptive manner. The subjects were 25 students of class X A, Madrasah Aliyah Sunan Pandanaran. The actions taken were in the form of imagery exercise integration into forward roll teaching. The collecting of the research data was through performance tests, observation, and self-efficacy scale questionnaire. The results show that through the imagery exercise program that is integrated into the lesson, students’ self-efficacy and learning outcome increase.
Penyusunan norma tes fisik pencak silat remaja kategori tanding
Authors: Saputro Deny Pradana , Siswantoyo Siswantoyo 
Published: July 2019

Penelitian ini bertujuan untuk: menyusun norma tes fisik pencak silat remaja kategori tanding. Penelitian ini menggunakan metode survei. Sampel yang digunakan dalam penelitian ini adalah atlet pencak silat remaja kategori tanding DIY yang berjumlah 42 atlet putra dan 46 atlet putri. Penyusunan norma menggunakan rumus norma 5 skala. Teknik analisis data menggunakan pearson correlation. Hasil penelitian berupa norma tes fisik pencak silat remaja kategori tanding yang terdiri dari 8 item tes, yaitu: fleksibilitas (sit and reach), kecepatan (sprint 30 meter), kekuatan lengan (push up 30 detik), kekuatan tungkai (wall sit test), kelincahan (side step), power tungkai (standing broad jump), daya tahan anaerobik (sprint 300 meter), dan daya tahan aerobik (multy fitness test). Tes dinyatakan valid dan reliabel dengan p < 0,05. Norm drafting of pencak silat physical test for adolescent fighting categoryAbstractThis research aimed to know the norm of pencak silat physical test for adolescent fighting category. This research used survey method. The sample in this research was 42 men and 46 women of Pencak Silat adolescent fighting category. Data analysis used Pearson correlation.The result of the research was the norm of pencak silat physical test for adolescent fighting category, it was consisting of 8 test items: flexibility (sit and reach), speed (30 meters sprint), arm strength (30 seconds push up), leg strength (wall sit test), agility (side step), leg power (standing broad jump), anaerobic endurance (300 meters sprint) and (8) aerobic endurance (multy fitness test). The test was valid and reliable with p < 0,05.