bluuebunny/crossref_metadata_2025_split huggingface dataset:
High‐Performance Synaptic Devices Based on Cross‐linked Organic Electrochemical Transistors with Dual Ion Gel
Authors: Lee Chang Min , Kim Yonghee , Kim Woojo , Lee Eunho , Lee Eun Kwang 
Published: November 2024

AbstractOrganic electrochemical transistors (OECTs) represent a promising approach for flexible, wearable, biomedical electronics, and sensors integrated with diverse substrates. Their ability to operate at low voltages and interact effectively with biological systems makes them particularly suitable for neuromorphic applications. For neuromorphic devices, OECTs must enhance electrical performance, biocompatibility, and signal storage/erasure capabilities. While UV cross‐linking methods with various side effects on organic semiconductors are predominant in improving mobility and current retention time, thermal cross‐linking based on the solution process has not been extensively explored. Additionally, despite significant research on the modification of electrolyte property, the ionic charge compensation mechanisms between multiple electrolytes are still unclear. This study employs a cross‐linking strategy involving the chemical reaction of poly(3‐hexylthiophene‐2,5‐diyl) (P3HT) with di‐tert‐butyl‐peroxide (DTBP) to create a cross‐linked P3HT active layer. Furthermore, a dual ion gel structure combining a conventional ion gel with a chitosan‐based ion gel is investigated for increased ionic transport to enhance OECT performance. Using the above two methods, the enhanced electrical performance showing the mobility of 25 F cm−1 V−1 s−1 and synaptic properties showing long‐term plasticity of cross‐linked OECTs with a dual ion gel structure are demonstrated, suggesting their potential application as high‐performance neuromorphic devices.
Thermally Induced Gelling Systems Based on Patchy Polymeric Micelles
Authors: Han Binru , Fujii Shota , van der Vlies André J. , Ghasemi Masoud , Del Mundo Joshua T. , Kiemle Sarah N. , Gomez Esther W. , Gomez Enrique D. , Colby Ralph H. , Hasegawa Urara 
Published: November 2024

AbstractThermogels that exhibit a sol‐gel transition at body temperature represent a promising class of injectable biomaterials for biomedical applications. Thermogels reported thus far are generally composed of amphiphilic block copolymer micelles with an isotropic thermosensitive surface that induces intermicellar aggregation upon heating. Despite the promise, these hydrogels exhibit low mechanical strengths due to their uncontrollable aggregation resulting in void formation. To gain better control over intermicellar assembly, herein a novel thermogel design concept is presented based on patchy polymeric micelles bearing multiple thermosensitive surface domains. These domains serve as “patches” to bridge the micelles to form a percolated network structure. Patchy micelles are prepared from a binary mixture of amphiphilic block copolymers: Poly(N‐acryloylmorpholine)‐b‐poly(N‐benzylacrylamide) (PAM‐PBzAM) and poly (N‐isopropyl acrylamide)‐b‐poly(N‐benzylacrylamide) (PNIPAM‐PBzAM), where PBzAM, PAM and PNIPAM are the hydrophobic, hydrophilic and thermosensitive blocks, respectively. At 25 °C, the polymers self‐assembled into mixed shell micelles having a phase‐separated shell with PAM‐ and PNIPAM‐rich domains. At 37 °C, the PNIPAM domains undergo a hydrophilic‐to‐hydrophobic transition to induce intermicellar assembly into entangled worm‐like structures resulting in hydrogel formation. Patchy micelles form a homogeneous network structure without voids. The micelle design significantly affects the inter‐micellar assembly, the thermogelling behavior, and the mechanical properties of the hydrogels.
Single‐Mode Lasing by Selective Mode Structure Breaking
Authors: Mao Wangqi , Liu Liang , Xu Chenni , Yang Liu , Lin Ruotian , Wang Xiaoxia , Jiang Mingming , Dong Hongxing , Zhang Long , Pan Anlian 
Published: November 2024

AbstractSingle‐mode lasers are highly desirable for applications in optical communication, quantum information, and photonic computing, but their realization is challenging due to the competition of multiple closely spaced resonant modes in microcavities. This paper proposes a novel approach, termed mode structure breaking, to achieve high‐performance single‐mode lasing in an individual laser cavity. By introducing selective spatial structure defects, the mode structure of competing modes can be broken, enabling single‐mode selection without huge losses. As proof of concept, femtosecond (fs)‐laser ablation is experimentally employed to introduce external angle defects on a microdisk cavity, effectively eliminating mismatched competing modes and thus achieving single‐mode lasing output. The lasing characteristics are further optimized by incorporating a punched hole to suppress remaining high‐order lasing modes. Notably, the fabricated perovskite laser sources, which are called mode‐structure‐breaking lasers, demonstrate excellent single‐mode lasing properties, including stability, an ultralow threshold (≈2.31 µJ cm−2), and a narrow linewidth (≈0.15 nm). Conclusively, this comprehensive study of manipulating lasing mode by breaking mode structure may provide a promising approach to realizing single‐mode lasing in a single structure, which is significant for producing on‐chip laser source arrays for use in photonic integrated circuits.
Advanced Electrode Materials for Low‐Temperature Na Storage
Authors: Zhu Wensun , Xu Shitan , Yang Shoumeng , Yang Yang , Rui Xianhong 
Published: November 2024

AbstractSodium‐ion batteries have drawn worldwide attention as ideal candidates for the upcoming generation of large‐scale electrical energy storage devices due to the low cost and abundance of sodium. Due to its unique electrochemical and chemical properties, sodium‐ion batteries hold the promise of breaking geographical and environmental constraints, achieving efficient sodium storage under low‐temperature conditions. However, low‐temperature sodium‐ion batteries, especially for their electrode materials, still face numerous challenges, such as the sluggish electrochemical reaction kinetics, poor material stability, significant volume changes leading to the pulverization of materials and the rapid degradation of battery performance. Here, it is focused on the modification methods for electrode materials, the research progress on cathode and anode materials of low‐temperature sodium‐ion batteries is summarized systematically and the other components of the electrodes are discussed briefly, and the shortcomings of the current research and possible future research directions are discussed thoroughly.
A Multi‐Channel Handheld Diagnostic Device Based on Green Biomimetic Material for Point‐of‐Care Testing of Vitamin C in Human Fluids
Authors: Fu Donglei , Dong Yueyan , Yin Junping , Zhang Bowen , Zhang Shuaibo , Deng Junjie , Shui Hua , Liu Xinghai 
Published: November 2024

AbstractIn the era of “Great Health”, maintaining an appropriate level of vitamin C is crucial for human health as it directly impacts the proper functioning of the immune system. In this study, a handheld nonenzymatic electrochemical sensor based on biomimetic material prussian blue functionalized polydopamine is proposed for point‐of‐care testing (POCT) of vitamin C in human fluids. Particularly, Prussian blue, known as a bio‐antidote, and polydopamine, a main component of cuttlefish ink, ensure the safety and reliability of home testing. The experimental results quantitatively demonstrate that this electrochemical POCT sensor enables rapid and accurate determination of vitamin C with a wide linear detection range from 0.2 to 200 µm, a low limit of detection at 0.03 µm, and high sensitivity at 0.33 µA µm−1 cm−2. More importantly, the performance evaluation using human urine and saliva samples confirms satisfactory accuracy and recovery rates for vitamin C determination by this electrochemical POCT sensor. Thus, the proposed handheld electrochemical POCT sensor holds potential utility as an affordable tool for VC determination and home‐based healthcare.
Fabrication of Ultrahigh‐Loading Dual Copper Sites in Nitrogen‐Doped Porous Carbons Boosting Electroreduction of CO2 to C2H4 Under Neutral Conditions
Authors: Heng Jin‐Meng , Zhu Hao‐Lin , Zhao Zhen‐Hua , Liao Pei‐Qin , Chen Xiao‐Ming 
Published: November 2024

AbstractSynthesis of high‐loading atomic‐level dispersed catalysts for highly efficient electrochemical CO2 reduction reaction (eCO2RR) to ethylene (C2H4) in neutral electrolyte remain challenging tasks. To address common aggregation issues, a host‐guest strategy is employed, by using a metal‐azolate framework (MAF‐4) with nanocages as the host and a dinuclear Cu(I) complex as the guest, to form precursors for pyrolysis into a series of nitrogen‐doped porous carbons (NPCs) with varying loadings of dual copper sites, namely NPCMAF‐4‐Cu2‐21 (21.2 wt%), NPCMAF‐4‐Cu2‐11 (10.6 wt%), and NPCMAF‐4‐Cu2‐7 (6.9 wt%). Interestingly, as the loading of dual copper sites increased from 6.9 to 21.2 wt%, the partial current density for eCO2RR to yield C2H4 also gradually increased from 38.7 to 93.6 mA cm−2. In a 0.1 m KHCO3 electrolyte, at −1.4 V versus reversible hydrogen electrode (vs. RHE), NPCMAF‐4‐Cu2‐21 exhibits the excellent performance with a Faradaic efficiency of 52% and a current density of 180 mA cm−2. Such performance can be attributed to the presence of ultrahigh‐loading dual copper sites, which promotes C─C coupling and the formation of C2 products. The findings demonstrate the confinement effect of MAF‐4 with nanocages is conducive to the preparation of high‐loading atomic‐level catalysts.
Nanoparticles in Allergen‐Delivery Systems for Allergen‐Specific Immunotherapy
Authors: Lee Jiann Huey , Chandrawati Rona , Lee N. Alice 
Published: November 2024

AbstractAllergen‐specific immunotherapy (AIT) has demonstrated its ability to induce desensitization, resulting in reduced allergen‐specific immunoglobulin E (sIgE) accompanied by increased clinical thresholds. However, ensuring safety during therapy, especially with oral immunotherapy, and achieving long‐term tolerance continue to be significant challenges. To address these issues, a concept of nanoencapsulation of allergens has emerged. This paper reviews biodegradable and non‐biodegradable nanoparticles as an allergen‐delivery system, as well as adjuvants for the improvement of the efficacy of AIT. Of all the nanoparticles reviewed, polymethyl methacrylate (PMMA) and chitosan are the most popular nanoparticles for encapsulating macromolecular allergens for oral immunotherapy. Although poly(lactic‐co‐glycolic acid) (PLGA) demonstrates higher stability in the gastrointestinal environment and allergen‐loaded PLGA attenuates the sIgE antibody binding in a murine model, it has inconsistent loading capacity and is difficult to reproduce. Studies on biodistribution, pharmacokinetics, and pharmacodynamics of nanoparticles, however, should be highlighted to ensure the long‐term safety profile of utilizing nanoparticles in immunotherapy. In this regard, encapsulation efficiency and release behavior of allergens from nanoparticles are important components in predicting the safety and efficacy of treatments. The stability, reproducibility, and scalability of encapsulated allergens should also be considered for the translation to clinical applications.
Non‐Hermitian Global Synchronization
Authors: Zhang Weixuan , Di Fengxiao , Zhang Xiangdong 
Published: November 2024

AbstractSynchronization of coupled nonlinear oscillators is a prevalent phenomenon in natural systems and can play important roles in various fields of modern science, such as laser arrays and electric networks. However, achieving robust global synchronization has always been a significant challenge due to its extreme susceptibility to initial conditions and structural perturbations. Here, a novel approach is presented to achieve robust global synchronization by manipulating the interplay between non‐Hermitian physics and nonlinear dynamics. Remarkably, the initial‐state‐independent non‐Hermitian skin and topological global synchronization are proposed, exhibiting diverse anomalous effects such as the enlarged‐size triggered non‐Hermitian global synchronization and nonlinear skin states‐dominated global synchronization. To validate the findings, nonlinear topoelectrical circuits for experimental observation of non‐Hermitian global synchronization are designed and fabricated. The work opens up a promising avenue for establishing resilient global synchronization with potential applications in constructing high‐radiance laser arrays and topologically synchronized networks.
A prophylactic tyrosine kinase inhibitor strategy based on measurable residual disease pre‐transplantation for Ph+ acute lymphoblastic leukemia undergoing allogeneic hematopoietic stem cell transplantation: A prospective multicenter cohort study
Authors: Liu Hui , Xu Hui , Chi Peiru , Feng Zinan , Xu Xiaojun , Nie Danian , Li Xudong , Liang Xinquan , Fan Zhiping , Xu Na , Huang Fen , Lin Ren , Wang Zhixiang , Jin Hua , Zhou Hongsheng , Guo Xutao , Lin Dongjun , Sun Jing , Liu Qifa , Xuan Li 
Published: November 2024

AbstractRelapse is the major cause of treatment failure in Philadelphia chromosome‐positive (Ph+) acute lymphoblastic leukemia (ALL) undergoing allogeneic hematopoietic stem cell transplantation (allo‐HSCT). This study aimed to evaluate the effect of a prophylactic tyrosine kinase inhibitor (TKI) strategy on relapse in this population. Patients were assigned to prophylactic or control groups based on measurable residual disease (MRD) pre‐transplantation. The primary endpoint was the cumulative incidence of relapse. A total of 110 patients with Ph+ ALL undergoing allo‐HSCT were enrolled in this prospective study. Thirty‐eight patients with positive MRD pre‐transplantation were included in the prophylactic group, and 72 with negative MRD pre‐transplantation were included in the control group. The 4‐year cumulative incidence of relapse was 25.3% (95% CI: 12.1%–41.0%) and 20.3% (11.6%–30.7%; HR = 1.272, 95% CI: 0.551–2.940, p = .549), and non‐relapse mortality was 10.5% (3.3%–22.7%) and 9.7% (4.2%–17.9%; HR = 1.094, 95% CI: 0.320–3.738, p = .928) in the prophylactic and control groups. The 4‐year overall survival was 71.8% (53.2%–84.1%) and 84.1% (72.9%–90.9%; HR = 1.746, 95% CI: 0.741–4.112, p = .196), and leukemia‐free survival was 64.1% (45.8%–77.7%) and 70.0% (57.6%–79.4%; HR = 1.212, 95% CI: 0.607–2.421, p = .585) in the prophylactic and control groups. Our results suggest that prophylactic TKI post‐HSCT in patients with positive MRD pre‐transplantation can produce outcomes comparable to negative MRD pre‐transplantation without TKI post‐HSCT.
Clinical and Immune Effects of Peri‐Transplantation JAK Inhibition for Myelofibrosis
Authors: Rathje Kristin , Gagelmann Nico , Badbaran Anita , Langebrake Claudia , Dadkhah Adrin , Richter Johanna , Massoud Radwan , Schäfersküpper Mathias , Marquard Franziska E. , Oechsler Sofia , Klyuchnikov Evgeny , Rudolph Ina , Heidenreich Silke , Niederwieser Christian , Lueck Catherina , Janson Dietlinde , Wolschke Christine , Fehse Boris , Ayuk Francis , Kröger Nicolaus 
Published: November 2024

ABSTRACTDespite the introduction of JAK inhibitors, allogeneic hematopoietic cell transplant remains the only potentially curative treatment for patients with myelofibrosis but has considerable treatment‐related complications. Whether the incorporation of JAK inhibition into the transplant algorithm leads to improved outcomes is still unclear. Here, we analyzed different transplant platforms in myelofibrosis patients undergoing a first transplant, comparing immune profiles and outcomes of (1) 33 patients continuing JAK inhibition at start of conditioning until stable engraftment (PERI‐group), (2) 38 patients receiving JAK inhibition prior to transplant until start of conditioning (PRE‐group), and (3) 38 patients that had never received JAK inhibition (NON‐group). Patients in the PERI‐group showed significantly higher early B‐cell recovery as well as significantly increased late recovery of gamma‐delta T cells and NK cells. We observed excellent neutrophil and platelet engraftment (100% for both) in the PERI‐group and no hematotoxic effects or increased rates of infections following peri‐transplant JAK inhibition. Cumulative incidence of acute graft‐versus‐host disease (GvHD) grade II‐IV at day 100 after transplant was 15% in the PERI‐group versus 29% in the PRE‐group versus 34% in the NON‐group. Cumulative incidence of relapse at 1 year after transplant was 9% in the PERI‐group compared with 16% in the PRE‐group and 18% in the NON‐group. In conclusion, peri‐transplant JAK inhibition was feasible with promising engraftment and acute GvHD rates, though deserves further investigation.
Tailoring of Novel Ru (III) and Cr (III) Salen Complexes as Catalysts for a Sustainable and Green Synthesis of Dihydro‐tetrazolo [1,5‐a] thiazolo [4,5‐d] pyrimidin‐6‐yl morpholine: Experimental and Theoretical Approaches
Authors: El‐Remaily Mahmoud Abd El Aleem Ali Ali , Eskander Thomas Nady A. , Alzahrani Abdullah Yahya Abdullah , Alsehli Mosa , Al‐Ghamdi Khalaf , AL Mughram Mohammed H. , El‐Hady Omar. M. , Feizi‐Dehnayebi Mehran , Abu‐Dief Ahmed M. 
Published: November 2024

ABSTRACTTwo novel Cr (III) and Ru (III) salen complexes based on {3,4‐Bis‐[(5‐chloro‐2‐hydroxy‐benzylidene)‐amino]‐phenyl}‐phenyl‐methanone ligand (CSAB) were synthesized. The complexes were characterized using various spectral and analytical methods. The catalytic performance of the CSAB complexes was investigated via a four‐component condensation reaction involving aromatic aldehydes, rhodamine, morpholine, and 5‐aminotetrazole under mild, environmentally friendly conditions. Different Lewis acids, bases, ionic liquid catalysts, solvents, and catalyst amounts were assessed to optimize the reaction parameters. Both catalyst systems demonstrated robust catalytic activity under strictly managed conditions, with the heterogeneous catalyst CSAB‐Ru showing superior efficacy compared to the homogeneous CSAB‐Cr catalyst. The study confirmed the catalytic capabilities of both complexes and evaluated their recyclability and reusability. The heterogeneous catalyst (CSAB‐Ru) could be reused seven times, whereas the homogeneous catalyst (CSAB‐Cr) could be recycled four times. Both complexes demonstrated strong catalytic activity and selectivity, resulting in high product yields. The study provides insights into the synthetic applications of novel CSAB complexes, highlighting their potential in organic transformations. It emphasizes their ease of use, safety, stability, component availability, quick reaction times, and high yields, making them promising for future industrial applications.
Toward Highly Toughened Polylactide/Polycaprolactone‐Based Polyurethane Blends With Shape Memory Property via Reactive Blending
Authors: Li Haochen , Zhang Xiang , Wang Jingjing , Xing Qian , Li Rongbo , Dong Xia 
Published: November 2024

ABSTRACTReactive blending has proven to be a versatile and efficient method for enhancing the impact toughness of polylactide (PLA). PLA/cross‐linked polycaprolactone‐based polyurethane (c‐PCLU) blends are prepared by reactive blending of PLA with PCL triol and hexamethylene diisocyanate (HDI). The reaction mechanism, compatibility, crystallization behavior, rheology behavior, mechanical performance, and shape memory property are thoroughly studied. The FTIR results confirmed that the NCO groups of HDI reacted with the hydroxyl groups of PLA and PCL triol, leading to the in situ formation of c‐PCLU and PLA‐co‐PCLU. The phase morphology exhibits a sea‐island structure, suggesting incompatibility between the two phases. The compatibility of the blends is improved with the increase of the PCL triol feeding ratio. The crystallization ability of PLA is retarded in the reactive blend. Both the elongation at break and the shape recovery ratio increase with c‐PCLU content, reaching up to 94.0% and 92.6%, respectively. These findings show that the formation of c‐PCLU greatly enhanced the toughness and shape memory performance of PLA.
Lipase pretreatment enhances biochar‐assisted anaerobic digestion of food waste
Authors: Ouyang Yue , Liu Ying , Tian Longjin , Ding Yongyu , Fan Guozhi , Pan Cheng , Cheng Qunpeng 
Published: November 2024

AbstractAnaerobic digestion is a promising technology for the treatment of food waste (FW) but it requires optimization to improve its performance. This study investigated whether combining the addition of biochar with lipase pretreatment could improve the anaerobic digestion of FW. The results showed that biochar stimulated the release of soluble substances, resulting in an increase in the methane yield of groups with added biochar by 16.24% to 19.36% in comparison with the group without biochar. Lipase pretreatment substantially shortened the fermentation time required to complete the anaerobic digestion, from 15 to 9 days. Lipase pretreatment further improved microbial abundance and promoted the enrichment of functional microbes in the anaerobic digestion of FW mediated by biochar. It also changed the methane production pathway from acetotrophic to hydrogenotrophic, thereby ensuring the stability of the anaerobic digestion system in the presence of a high ammonia nitrogen concentration.
Capturing Chemotherapy and Radiotherapy Dose Among Breast Cancer Patients With the Utah All‐Payer Claims Database Compared With Gold‐Standard Abstraction
Authors: Koric Alzina , Chang Chun‐Pin Esther , Lloyd Shane , Dodson Mark , Deshmukh Vikrant G. , Newman Michael G. , Date Ankita P. , Doherty Jen A. , Gren Lisa H. , Porucznik Christina A. , Haaland Benjamin A. , Henry N. Lynn , Hashibe Mia 
Published: November 2024

ABSTRACTObjectiveTo evaluate the validity of the Utah statewide All‐Payer Claims Database (APCD), we compared breast cancer‐specific treatments and dosages with gold‐standard abstraction of medical records.Study DesignIn this pilot study, breast cancer treatments were abstracted by a certified tumor registrar at the Utah Cancer Registry (UCR) for patients diagnosed in 2013 with breast cancer. The abstraction of medical records was the gold standard for comparison with treatments identified in the APCD. The reliability and agreement between the treatment identified in the APCD and abstraction data were measured with sensitivity and specificity. Dose consistency was measured with the intraclass correlation coefficients (ICC).ResultsCompared with the 186 abstractions, the sensitivity of the APCD to identify chemotherapy agents was high: 89% for any agent, 91% for carboplatin, 83% for docetaxel, 82% for doxorubicin, or 94.7% for biologic therapy. The consistency between the chemotherapy dosage identified in the claims and the abstraction varied from 63% to 76%. For radiotherapy, the sensitivity of the claims to identify the completed radiotherapy regimen was 66%. The ICC between radiotherapy doses identified in the claims and the abstraction was 54% (95% confidence interval [CI], 48%, 67%).ConclusionsEmploying these novel methods, the claims were highly reliable in identifying cancer treatment agents overall, namely carboplatin, docetaxel, and trastuzumab. The claims were of moderate utility in capturing the treatment dose information. In addition to the APCD, the use of multiple data sources improved the completeness of cancer treatment information.