bluuebunny/crossref_metadata_2025_split huggingface dataset:
Neurobiological mechanisms of social cognition treatment in high-functioning adults with autism spectrum disorder
Authors: Rosenblau Gabriela , O'Connell Garret , Heekeren Hauke R. , Dziobek Isabel 
Published: September 2019

AbstractBackgroundThe promise of precision medicine for autism spectrum disorder (ASD) hinges on developing neuroscience-informed individualized interventions. Taking an important step in this direction, we investigated neuroplasticity in response to an ecologically-valid, computer-based social-cognitive training (SCOTT).MethodsIn an active control group design, 48 adults with ASD were randomly assigned to a 3-month SCOTT or non-social computer training. Participants completed behavioral tasks, a functional and structural magnetic resonance imaging session before and after the training period.ResultsThe SCOTT group showed social-cognitive improvements on close and distant generalization tasks. The improvements scaled with reductions in functional activity and increases in cortical thickness in prefrontal regions.ConclusionIn sum, we provide evidence for the sensitivity of neuroscientific methods to reflect training-induced social-cognitive improvements in adults with ASD. These results encourage the use of neuroimaging data to describe and quantify treatment-related changes more broadly.
Circe’s Instructions to Odysseus (OD. 10.507–40) As an Early Sibylline Oracle
Authors: Faraone Christopher A. 
Published: September 2019

AbstractScholars have noted that Circe’s instructions to Odysseus illustrate a speech type-scene comprised of directions and then instructions – or ‘map’ and ‘script’: first she tells him (i) how to get to the entrance to Hades and then (ii) what rituals to do and what words to say after he gets there (Od. 10.507–40). This essay argues that the Odyssey poet is, in fact, using the vocabulary and syntax of an important subset of this speech-act: hexametrical oracles, as we see them quoted a few centuries later by Herodotus and parodied by Aristophanes. Her advice, moreover, also echoes closely a specific kind of Archaic oracle that directed Greek colonists to a far-away place and that was typical of the female prophets called ‘Sibyls’, who lived near the Aegean coastline in places where the Homeric poems were originally composed and performed.
Autoimmune cytopenias (AIC) following allogeneic haematopoietic stem cell transplant for acquired aplastic anaemia: a joint study of the Autoimmune Diseases and Severe Aplastic Anaemia Working Parties (ADWP/SAAWP) of the European Society for Blood and Marrow Transplantation (EBMT)
Authors: Miller Paul D. E. , Snowden John A. , De Latour Regis Peffault , Iacobelli Simona , Eikema Diderik-Jan , Knol Cora , Marsh Judith C. W. , Rice Carmel , Koh Mickey , Fagioli Franca , Chaganti Sridhar , Finke Jürgen , Duarte Rafael F. , Bader Peter , Farge Dominique , Passweg Jakob R. , Madrigal J. Alejandro , Dufour Carlo 
Published: September 2019

AbstractThis retrospective study explored the incidence of autoimmune cytopenia (AIC) in 530 paediatric and adult patients with acquired aplastic anaemia (aAA) who underwent first allogeneic HSCT between 2002 and 2012. AIC was a rare complication with a cumulative incidence of AIC at 1, 3, 5 and 10 years post HSCT of 2.5% (1.2–3.9 95% CI), 4.4% (2.6–6.2 95% CI), 4.6% (2.8–6.5 95% CI) and 5.1% (3.1–7.2 95% CI). Overall survival at 5 years after diagnosis of AIC was 85.9% (71–100 95% CI). Twenty-five patients were diagnosed with AIC at a median of 10.6 (2.6–91.5) months post HSCT. Eight (32%) patients were diagnosed with immune thrombocytopenia (ITP), seven (28%) with autoimmune haemolytic anaemia (AIHA), seven (24%) with Evans syndrome and four (16%) with autoimmune neutropenia (AIN). Treatment strategies were heterogeneous. Complete responses were seen in 12 of 25 patients, with death in three patients. In multivariable Cox analysis of a subgroup of 475 patients, peripheral blood stem cell (PBSC) transplant was associated with higher risk of AIC compared with bone marrow (BM) when conditioning regimens contained fludarabine and/or alemtuzumab (2.81 [1.06–7.49 95% CI];p = 0.038), or anti-thymocyte globulin (ATG) (2.86 [1.11–7.37 95% CI];p = 0.029). Myeloablative conditioning was associated with a lower risk of AIC compared with reduced intensity conditioning (RIC) in fludarabine and/or alemtuzumab (0.34 [0.12–0.98 95% CI];p = 0.046) and ATG containing regimens (0.34 [0.12–0.95 95% CI];p = 0.04). These findings provide clinically useful information regarding the incidence of a rare and potentially life-threatening complication of allogeneic HSCT for aAA, and further support for BM as the preferred stem cell source for transplant of patients with aAA.
Alterations in ALK/ROS1/NTRK/MET drive a group of infantile hemispheric gliomas
Authors: Guerreiro Stucklin Ana S. , Ryall Scott , Fukuoka Kohei , Zapotocky Michal , Lassaletta Alvaro , Li Christopher , Bridge Taylor , Kim Byungjin , Arnoldo Anthony , Kowalski Paul E. , Zhong Yvonne , Johnson Monique , Li Claire , Ramani Arun K. , Siddaway Robert , Nobre Liana Figueiredo , de Antonellis Pasqualino , Dunham Christopher , Cheng Sylvia , Boué Daniel R. , Finlay Jonathan L. , Coven Scott L. , de Prada Inmaculada , Perez-Somarriba Marta , Faria Claudia C. , Grotzer Michael A. , Rushing Elisabeth , Sumerauer David , Zamecnik Josef , Krskova Lenka , Garcia Ariza Miguel , Cruz Ofelia , Morales La Madrid Andres , Solano Palma , Terashima Keita , Nakano Yoshiko , Ichimura Koichi , Nagane Motoo , Sakamoto Hiroaki , Gil-da-Costa Maria Joao , Silva Roberto , Johnston Donna L. , Michaud Jean , Wilson Bev , van Landeghem Frank K. H. , Oviedo Angelica , McNeely P. Daniel , Crooks Bruce , Fried Iris , Zhukova Nataliya , Hansford Jordan R. , Nageswararao Amulya , Garzia Livia , Shago Mary , Brudno Michael , Irwin Meredith S. , Bartels Ute , Ramaswamy Vijay , Bouffet Eric , Taylor Michael D. , Tabori Uri , Hawkins Cynthia 
Published: September 2019

AbstractInfant gliomas have paradoxical clinical behavior compared to those in children and adults: low-grade tumors have a higher mortality rate, while high-grade tumors have a better outcome. However, we have little understanding of their biology and therefore cannot explain this behavior nor what constitutes optimal clinical management. Here we report a comprehensive genetic analysis of an international cohort of clinically annotated infant gliomas, revealing 3 clinical subgroups. Group 1 tumors arise in the cerebral hemispheres and harbor alterations in the receptor tyrosine kinasesALK,ROS1,NTRKandMET. These are typically single-events and confer an intermediate outcome. Groups 2 and 3 gliomas harborRAS/MAPKpathway mutations and arise in the hemispheres and midline, respectively. Group 2 tumors have excellent long-term survival, while group 3 tumors progress rapidly and do not respond well to chemoradiation. We conclude that infant gliomas comprise 3 subgroups, justifying the need for specialized therapeutic strategies.
Chromatin-informed inference of transcriptional programs in gynecologic and basal breast cancers
Authors: Osmanbeyoglu Hatice U. , Shimizu Fumiko , Rynne-Vidal Angela , Alonso-Curbelo Direna , Chen Hsuan-An , Wen Hannah Y. , Yeung Tsz-Lun , Jelinic Petar , Razavi Pedram , Lowe Scott W. , Mok Samuel C. , Chiosis Gabriela , Levine Douglas A. , Leslie Christina S. 
Published: September 2019

AbstractChromatin accessibility data can elucidate the developmental origin of cancer cells and reveal the enhancer landscape of key oncogenic transcriptional regulators. We develop a computational strategy called PSIONIC (patient-specific inference of networks informed by chromatin) to combine chromatin accessibility data with large tumor expression data and model the effect of enhancers on transcriptional programs in multiple cancers. We generate a new ATAC-seq data profiling chromatin accessibility in gynecologic and basal breast cancer cell lines and apply PSIONIC to 723 patient and 96 cell line RNA-seq profiles from ovarian, uterine, and basal breast cancers. Our computational framework enables us to share information across tumors to learn patient-specific TF activities, revealing regulatory differences between and within tumor types. PSIONIC-predicted activity for MTF1 in cell line models correlates with sensitivity to MTF1 inhibition, showing the potential of our approach for personalized therapy. Many identified TFs are significantly associated with survival outcome. To validate PSIONIC-derived prognostic TFs, we perform immunohistochemical analyses in 31 uterine serous tumors for ETV6 and 45 basal breast tumors for MITF and confirm that the corresponding protein expression patterns are also significantly associated with prognosis.
Cell type-specific modulation of sensory and affective components of itch in the periaqueductal gray
Authors: Samineni Vijay K. , Grajales-Reyes Jose G. , Sundaram Saranya S. , Yoo Judy J. , Gereau Robert W. 
Published: September 2019

AbstractItch is a distinct aversive sensation that elicits a strong urge to scratch. Despite recent advances in our understanding of the peripheral basis of itch, we know very little regarding how central neural circuits modulate acute and chronic itch processing. Here we establish the causal contributions of defined periaqueductal gray (PAG) neuronal populations in itch modulation in mice. Chemogenetic manipulations demonstrate bidirectional modulation of scratching by neurons in the PAG. Fiber photometry studies show that activity of GABAergic and glutamatergic neurons in the PAG is modulated in an opposing manner during chloroquine-evoked scratching. Furthermore, activation of PAG GABAergic neurons or inhibition of glutamatergic neurons resulted in attenuation of scratching in both acute and chronic pruritis. Surprisingly, PAG GABAergic neurons, but not glutamatergic neurons, may encode the aversive component of itch. Thus, the PAG represents a neuromodulatory hub that regulates both the sensory and affective aspects of acute and chronic itch.
Low expression of RNA sensors impacts Zika virus infection in the lower female reproductive tract
Authors: Khan Shahzada , Lew Irene , Wu Frank , Fritts Linda , Fontaine Krystal A. , Tomar Sakshi , Trapecar Martin , Shehata Hesham M. , Ott Melanie , Miller Christopher J. , Sanjabi Shomyseh 
Published: September 2019

AbstractInnate immune responses to Zika virus (ZIKV) are dampened in the lower female reproductive tract (LFRT) compared to other tissues, but the mechanism that underlies this vulnerability is poorly understood. Using tissues from uninfected and vaginally ZIKV-infected macaques and mice, we show that low basal expression of RNA-sensing pattern recognition receptors (PRRs), or their co-receptors, in the LFRT contributes to high viral replication in this tissue. In the LFRT, ZIKV sensing provides limited protection against viral replication, and the sensors are also minimally induced after vaginal infection. While IFNα/β receptor signaling offers minimal protection in the LFRT, it is required to prevent dissemination of ZIKV to other tissues, including the upper FRT. Our findings support a role for RNA-sensing PRRs in the dampened innate immunity against ZIKV in the LFRT compared to other tissues and underlie potential implications for systemic dissemination upon heterosexual transmission of ZIKV in women.
Sustainable ecofriendly phytoextract mediated one pot green recovery of chitosan
Authors: Gopal Judy , Muthu Manikandan , Dhakshanamurthy Thirumalai , Kim Ki Jun , Hasan Nazim , Kwon Seong Jung , Chun Sechul 
Published: September 2019

AbstractChitin and chitosan are biopolymers that have diverse applications in medicine, agriculture, food, cosmetics, pharmaceuticals, wastewater treatment and textiles. With bio-origins, they easily blend with biological systems and show exemplified compatibility which is mandatory when it comes to biomedical research. Chitin and chitosan are ecofriendly, however the processes that are used to recover them aren’t ecofriendly. The focus of this work is to attempt an ecofriendly, sustainable phytomediated one pot recovery of chitosan from commercial chitin and from crab and shrimp shells and squid pen solid wastes. Graviola extracts have been employed, given the fact file that their active ingredients acetogenins actively interact with chitin in insects (resulting in its application as an insecticide). With that as the core idea, the graviola extracts were chosen for orchestrating chitin recovery and a possible chitin to chitosan transformation. The results confirm that graviola extracts did succeed in recovery of chitosan nanofibers from commercial chitin flakes and recovery of chitosan particles directly from solid marine wastes of crab, shrimp and squids. This is a first time report of a phyto-extract mediated novel chitosan synthesis method.
Dynamic Enhancement of Nitric Oxide Radioluminescence with Nitrogen Purge
Authors: Kerst Thomas , Toivonen Juha 
Published: September 2019

AbstractRemote detection of alpha radiation is commonly realised by collecting the light, the radioluminescence, that is produced when alpha particles are stopped in air. Radioluminescence of nitric oxide (NO) is primarily emitted between 200 nm and 300 nm, which makes it possible to use it for remote detection under daylight conditions. Quenching by ambient oxygen and water vapour, however, makes it generally difficult to effectively create NO radioluminescence. We present the detection of intense NO radioluminescence in ambient air under standard indoor lighting conditions using a nitrogen purge. The nitrogen contained NO impurities that were intrinsic to the gas and had not explicitly been added. We study the mechanisms that govern the NO radioluminescence production and introduce a model to describe the dynamics of the process. The level of NO contained in the gas was found to determine how successful a purge can be. We conclude by discussing possible applications of the technique in nitrogen-flushed gloveboxes at nuclear facilities where NO concentration of 100 ppb–1 ppm would be sufficient for efficient optical alpha radiation detection in standard lighting conditions.
CFH exerts anti-oxidant effects on retinal pigment epithelial cells independently from protecting against membrane attack complex
Authors: Borras Céline , Canonica Jérémie , Jorieux Sylvie , Abache Toufik , El Sanharawi Mohamed , Klein Christophe , Delaunay Kimberley , Jonet Laurent , Salvodelli Michèle , Naud Marie-Christine , Arsenijevic Yvan , Shalabi Andrée , Souchaud Landry , Behar-Cohen Francine , Dinet Virginie 
Published: September 2019

AbstractAge Related Macular Degeneration (AMD) is the first cause of social blindness in people aged over 65 leading to atrophy of retinal pigment epithelial cells (RPE), photoreceptors and choroids, eventually associated with choroidal neovascularization. Accumulation of undigested cellular debris within RPE cells or under the RPE (Drusen), oxidative stress and inflammatory mediators contribute to the RPE cell death. The major risk to develop AMD is the Y402H polymorphism of complement factor H (CFH). CFH interacting with oxidized phospholipids on the RPE membrane modulates the functions of these cells, but the exact role of CFH in RPE cell death and survival remain poorly understood. The aim of this study was to analyze the potential protective mechanism of CFH on RPE cells submitted to oxidative stress. Upon exposure to oxidized lipids 4-HNE (4-hydroxy-2-nonenal) derived from photoreceptors, both the human RPE cell line ARPE-19 and RPE cells derived from human induced pluripotent stem cells were protected from death only in the presence of the full length human recombinant CFH in the culture medium. This protective effect was independent from the membrane attack complex (MAC) formation. CFH maintained RPE cells tight junctions’ structure and regulated the caspase dependent apoptosis process. These results demonstrated the CFH anti-oxidative stress functions independently of its capacity to inhibit MAC formation.
Therapeutic effect of mesenchymal stem cells derived from human umbilical cord in rabbit temporomandibular joint model of osteoarthritis
Authors: Kim Hyunjeong , Yang Gwanghyun , Park Jumi , Choi Jene , Kang Eunju , Lee Bu-Kyu 
Published: September 2019

AbstractOsteoarthritis (OA) is a degenerative condition of the temporomandibular joint (TMJ) characterised by chronic inflammation and damage to joint structures. Because of the complexity of TMJ-OA, only symptomatic treatments are currently available. Recent reports have shown that many of stem cells can exert anti-inflammatory and tissue-regenerating effects. In this study, we investigated the potential cartilage-regenerating and anti-inflammatory effects of human umbilical cord matrix-mesenchymal stem cells (hUCM-MSCs) for the treatment of TMJ-OA. hUCM-MSC lines, isolated from different donors, which showed different activitiesin vitro. Using a selected cell line, we used different concentrations of hUCM-MSCs to assess therapeutic effects in a rabbit model of monosodium iodoacetate-induced TMJ-OA. Compared with the untreated control group, the potential regenerative result and anti-inflammatory effects of hUCM-MSCs were evident at all the tested concentrations in rabbits with induced TMJ-OA. The median dose of hUCM-MSCs showed the prominent cartilage protective effect and further cartilage regeneration potential. This effect occurred via upregulated expression of growth factors, extracellular matrix markers, and anti-inflammatory cytokines, and reduced expression of pro-inflammatory cytokines. The anti-inflammatory effect of hUCM-MSCs was comparable to that of dexamethasone (DEX). However, only hUCM-MSCs showed potential chondrogenesis effects in this study. In conclusion, our results indicate that hUCM-MSCs may be an effective treatment option for the treatment of TMJ-OA.
Attention to issues and facts
Authors: Vargo Chris J. , Hopp Toby 
Published: September 2019

Abstract
Need for orientation (NFO) has long been accepted as an antecedent to agenda-setting effects. This study assessed whether NFO can go further to explain a specific behavior, why individuals share political news on Facebook. A new method is introduced that combines survey data with users’ Facebook accounts and their actual Facebook posts to reveal the historical news sharing behaviors of 741 U.S. citizens. Computer-assisted content analysis is employed to analyze nearly a million messages for the presence of political news content. Results suggest that a key component found in need for orientation – attention to relevant issues and facts – predicts observed political news sharing on Facebook. Other demographics such as age and gender also predict news sharing behavior. In all, the model employed here significantly predicts news sharing while commonly regarded antecedents to political sharing, including news consumption and political interest, fail to do so.
Language focused episodes by monolingual teachers in English Medium Instruction science lessons
Authors: An Jiangshan , Macaro Ernesto , Childs Ann 
Published: September 2019

Abstract
This study is situated in a newly emerging EMI setting in China where an Anglophone high school curriculum is
taught by predominantly foreign teachers through English to local Chinese students. These teachers are termed ‘monolingual
teachers’ in the sense that they cannot use the students’ L1 as a resource in their teaching should they wish to, as opposed to
the typical bilingual teachers commonly explored in the existing EMI literature. Through quantitative and qualitative analysis of
30 video-recorded EMI science lessons taught by 15 monolingual teachers we identified and explored the language-focused-episodes
(LFEs) where students’ attention was explicitly diverted from the content plane to the language plane. We found very limited
explicit language instruction, with non-technical vocabulary being the main type of LFEs, and only a narrow range of grammatical
features being attended to. The implications for this lack of focus on language are discussed in the context of monolingual
teachers but also with reference to the potential for bilingual teachers to use both L1 and L2 for LFEs.
NAD(P)H fluorescence lifetime measurements in fixed biological tissues
Authors: Chacko Jenu V , Eliceiri Kevin W 
Published: September 2019

Abstract
Autofluorescence based fluorescence lifetime imaging microscopy (AF-FLIM) techniques have come a long way from early studies on cancer characterization and have now been widely employed in several cellular and animal studies covering a wide range of diseases. The majority of research in autofluorescence imaging (AFI) study metabolic fluxes in live biological samples. However, tissues from clinical or scientific studies are often chemically fixed for preservation and stabilization of tissue morphology. Fixation is particularly crucial for enzymatic, functional, or histopathology studies. Interpretations of metabolic imaging such as optical redox intensity imaging and AF-FLIM, have often been viewed as potentially unreliable in a fixed sample due to lack of studies in this field. In this study, we carefully evaluate the possibility of extracting microenvironment information in fixed tissues using reduced nicotinamide adenine dinucleotide (phosphate) (NAD(P)H) endogenous fluorescence. The ability to distinguish changes such as metabolism and pH using intrinsic fluorescence in fixed tissues has great pathological value. In this work, we show that the lifetime based metabolic contrast in a sample is preserved after chemical fixation. The fluorescence lifetime of a sample increases with an additive fixative like formaldehyde; however, the fixed tissues retain metabolic signatures even after fixation. This study presents an opportunity to successfully image archived unstained histopathology tissues, and generate useful AF-FLIM signatures. We demonstrate the capability to draw metabolic interpretations in fixed tissues even after long periods of storage.
Relatedness economies, absorptive capacity, and economic catch-up: firm-level evidence from China
Authors: Howell Anthony 
Published: September 2019

Abstract
This paper examines the effect of agglomeration economies on firm productivity and the role of absorptive capacity in China. Taking into account the transitioning economy context, I further exploit the gradual and spatially uneven implementation of market-oriented reforms to track the relative importance of firms’ absorptive capacity for economic catch-up. The three main results are as follows. First, firms exhibit higher productivity when located in an area with a denser network of related activities, particularly for firms with higher absorptive capacity. Second, the sources of the productivity gains are driven by externalities that arise from better access to inputs, similar workers and technological-related knowledge spillovers. Third, the role of absorptive capacity becomes more important for boosting productivity following more versus less intensive market-oriented economic reforms. These findings have important policy implications for transitioning economies and suggest that market reforms promote efficiency improvements related to performing actual R&D as well as encourage firms to seek out external sources of knowledge in order to attain market competitiveness.
Holes in the Dike: The Global Savings Glut, U.S. House Prices, and the Long Shadow of Banking Deregulation
Authors: Hoffmann Mathias , Stewen Iryna 
Published: September 2019

Abstract
We show how capital inflows into and financial deregulation within the United States interacted in driving the recent boom and bust in U.S. housing prices. Interstate banking deregulation during the 1980s cast a long shadow: in states that opened their banking markets to out-of-state banks earlier, house prices were more sensitive to aggregate U.S. capital inflows during 1997–2012. Capital inflows relaxed the value-at-risk constraints of geographically diversified (“integrated”) U.S. banks more than those of local banks. Therefore, integrated banks absorbed a larger share of capital inflows and expanded mortgage lending more. This drove up housing prices.