bluuebunny/crossref_metadata_2025_split huggingface dataset:
I hate what you love: brand polarization and negativity towards brands as an opportunity for brand management
Authors: Osuna Ramírez Sergio Andrés , Veloutsou Cleopatra , Morgan-Thomas Anna 
Published: March 2019

PurposeNegativity towards a brand is typically conceived as a significant problem for brand managers. This paper aims to show that negativity towards a brand can represent an opportunity for companies when brand polarization occurs. To this end, the paper offers a new conception of the brand polarization phenomenon and reports exploratory findings on the benefits of consumers’ negativity towards brands in the context of brand polarization.Design/methodology/approachTo develop a conception of brand polarization, the paper builds on research on polarizing brands and extends it by integrating insights from systematic literature reviews in three bodies of literature: scholarship on brand rivalry and, separately, polarization in political science and social psychology. Using qualitative data from 22 semi-structured interviews, the paper explores possible advantages of brand polarization.FindingsThis paper defines the brand polarization phenomenon and identifies multiple perspectives on brand polarization. Specifically, the findings highlight three distinct parties that can benefit from brand polarization: the polarizing brand as an independent entity; the brand team behind the polarizing brand; and the passionate consumers involved with the polarizing brand. The data reveal specific advantages of brand polarization associated with the three parties involved.Practical implicationsManagers of brands with a polarizing nature could benefit from having identified a group of lovers and a group of haters, as this could allow them to improve their focus when developing and implementing the brands’ strategies.Originality/valueThis exploratory study is the first explicitly focusing on the brand polarization phenomenon and approaches negativity towards brands as a potential opportunity.
Analysing mobile advergaming effectiveness: the role of flow, game repetition and brand familiarity
Authors: Catalán Sara , Martínez Eva , Wallace Elaine 
Published: March 2019

PurposeThis paper aims to explain the effect of flow, game repetition and brand familiarity on players’ brand attitude and purchase intention in the context of mobile advergaming.Design/methodology/approachData from 227 participants who played a mobile advergame were analysed. Structural equation modelling with partial least squares was used to test the research model.FindingsThe results reveal that the independent variables (i.e. game repetition and brand familiarity) significantly influence the dependent variables explored in this study (i.e. brand attitude and purchase intentions of players). Results also show that brand familiarity influences players’ flow experience, which in turn significantly affects players’ purchase intentions.Research limitations/implicationsThe findings of this study are important for advertising practitioners and advergames’ developers as understanding the determinants of mobile advergaming effectiveness is crucial for designing successful advergames that persuade players the most.Originality/valueThis study contributes to the literature in two ways. First, it provides new insights into the effectiveness of mobile advergames, which is an under-researched area. Second, it offers empirical evidence of the effects of game repetition, flow and brand familiarity on mobile advergaming effectiveness.
The instrumental time of memory: local politics and urban aesthetics in a tourism context
Authors: Nogués-Pedregal Antonio-Miguel 
Published: March 2019

Purpose
This paper aims to show that tourism is one of the most perfect creations of the capitalist mode of production insofar as not only does it consume places and territories and perpetuate dependency relations, but in the expressive dimension, it also produces feelings and meanings and generates a new relationship of the past with the present and future (chronotope).

Design/methodology/approach
The study was carried out using a socio-anthropological approach with participant observation over several decades.

Findings
The modes of time are described and how the tourism chronotope shapes the historic centre of a consolidated tourist destination. The case study, analysed with the model of the “conversion of place through the mediation of tourism space”, illustrates the prevalence of instrumental and commercial values over one’s own aesthetic-expressive values in tourism contexts. This fact encourages the emergence of local political projects and the incorporation of uniformities outside the local place. These processes end up uprooting the anchors from collective memory. The definition of territories according to visitors’ imaginaries and expectations encourages the abusive occupation of public space and the adoption of new aesthetic attributes of urban space.

Research limitations/implications
Because of the chosen research approach and methodologies, the research results may lack generalisability. Therefore, researchers are encouraged to test both the model and the propositions further.

Originality/value
This study approaches the relationship of the idea Tourism with the idea Development based on the anchors of memory.
Dietary coconut oil ameliorates skin contact hypersensitivity through mead acid production in mice
Authors: Tiwari Prabha , Nagatake Takahiro , Hirata So‐ichiro , Sawane Kento , Saika Azusa , Shibata Yuki , Morimoto Sakiko , Honda Tetsuya , Adachi Jun , Abe Yuichi , Isoyama Junko , Tomonaga Takeshi , Kiyono Hiroshi , Kabashima Kenji , Kunisawa Jun 
Published: March 2019

AbstractCoconut oil is used as a dietary oil worldwide, and its healthy effects are recognized by the fact that coconut oil is easy to digest, helps in weight management, increases healthy cholesterol, and provides instant energy. Although topical application of coconut oil is known to reduce skin infection and inflammation, whether dietary coconut oil has any role in decreasing skin inflammation is unknown. In this study, we showed the impact of dietary coconut oil in allergic skin inflammation by using a mouse model of contact hypersensitivity (CHS). Mice maintained on coconut oil showed amelioration of skin inflammation and increased levels of cis‐5, 8, 11‐eicosatrienoic acid (mead acid) in serum. Intraperitoneal injection of mead acid inhibited CHS and reduced the number of neutrophils infiltrating to the skin. Detailed mechanistic studies unveiled that mead acid inhibited the directional migration of neutrophils by inhibiting the filamentous actin polymerization and leukotriene B4 production required for secondary recruitment of neutrophils. Our findings provide valuable insights into the preventive roles of coconut oil and mead acid against skin inflammation, thereby offering attractive therapeutic possibilities.
Macular vascular circulation and retinal oxygen saturation changes for idiopathic macular epiretinal membrane after vitrectomy
Authors: Li Zhixi , Zhang Jie , Lin Tao , Peng Wenyan , Lu Lin , Hu Jie 
Published: March 2019

AbstractPurposeTo investigate the postoperative changes in retinal‐choroidal blood flow area and retinal vascular oxygen saturation among patients with idiopathic macular epiretinal membranes (iERMs).MethodsThis study prospectively included 24 eyes of 24 consecutive patients who underwent vitrectomy for iERMs. The flow area of choriocapillary layer, retinal superficial capillary plexuses (SCPs) and retinal deep capillary plexuses (DCPs) were performed using optical coherence tomography angiography with angiovue prototype software, and retinal vascular oxygen saturation was measured using retinal oximeter with the built‐in software. The flow area of choriocapillary layers and mean retinal vessel oxygen saturation before and after surgery were compared.ResultsThree months after vitrectomy, the foveal flow area of choriocapillary layer increased clinically significantly from 1.5 ± 0.2 to 1.6 ± 0.2 mm2 (p = 0.02). The retinal vascular changes of SCPs and DCPs were not statistically significant. The mean retinal arterial oxygen saturation was 89.9 ± 11.3% preoperatively and increased to 94.5 ± 9.7% postoperatively (p = 0.04). Foveal retinal thickness revealed a clinically significant decrease from 547.8 ± 88.2 μm to 403.0 ± 47.5 μm after surgery (p < 0.05). Postoperative best corrected visual acuity had no statistically significant correlation with foveal flow area of the choriocapillary layer and retinal vascular oxygen saturation.ConclusionsThere was a decrease of retinal thickness, an improved flow area of choriocapillary layer in macular region, and an increase of retinal arterial vascular oxygen among iERMs patients after vitrectomy.
Acute interaction between oral glucose (75 g as Lucozade) and inorganic nitrate: Decreased insulin clearance, but lack of blood pressure‐lowering
Authors: Floyd Christopher N. , Lidder Satnam , Hunt Joanne , Omar Sami A. , McNeill Karen , Webb Andrew J. 
Published: March 2019

AimsDietary inorganic nitrate (NO3−) lowers peripheral blood pressure (BP) in healthy volunteers, but lacks such effect in individuals with, or at risk of, type 2 diabetes mellitus (T2DM). Whilst this is commonly assumed to be a consequence of chronic hyperglycaemia/hyperinsulinaemia, we hypothesized that acute physiological elevations in plasma [glucose]/[insulin] blunt the haemodynamic responses to NO3−, a pertinent question for carbohydrate‐rich Western diets.MethodsWe conducted an acute, randomized, placebo‐controlled, double‐blind, crossover study on the haemodynamic and metabolic effects of potassium nitrate (8 or 24 mmol KNO3) vs. potassium chloride (KCl; placebo) administered 1 hour prior to an oral glucose tolerance test in 33 healthy volunteers.ResultsCompared to placebo, there were no significant differences in systolic or diastolic BP (P = 0.27 and P = 0.30 on ANOVA, respectively) with KNO3, nor in pulse wave velocity or central systolic BP (P = 0.99 and P = 0.54 on ANOVA, respectively). Whilst there were significant elevations from baseline for plasma [glucose] and [C‐peptide], no differences between interventions were observed. A significant increase in plasma [insulin] was observed with KNO3 vs. KCl (n = 33; P = 0.014 on ANOVA) with the effect driven by the high‐dose cohort (24 mmol, n = 13; P < 0.001 on ANOVA; at T = 0.75 h mean difference 210.4 pmol/L (95% CI 28.5 to 392.3), P = 0.012).ConclusionsIn healthy adults, acute physiological elevations of plasma [glucose] and [insulin] result in a lack of BP‐lowering with dietary nitrate. The increase in plasma [insulin] without a corresponding change in [C‐peptide] or [glucose] suggests that high‐dose NO3− decreases insulin clearance. A likely mechanism is via NO‐dependent inhibition of insulin‐degrading enzyme.
Effect of CYP3A inhibitors on the pharmacokinetics of pevonedistat in patients with advanced solid tumours
Authors: Faessel Hélène , Nemunaitis John , Bauer Todd M. , Lockhart A. Craig , Faller Douglas V. , Sedarati Farhad , Zhou Xiaofei , Venkatakrishnan Karthik , Harvey R. Donald 
Published: March 2019

AimsThis phase I study evaluated the effects of the moderate cytochrome P450 (CYP) 3A inhibitor fluconazole and the strong CYP3A/P‐glycoprotein (P‐gp) inhibitor itraconazole on the pharmacokinetics of the investigational neural precursor cell expressed, developmentally downregulated 8 (NEDD8)‐activating enzyme inhibitor pevonedistat in patients with advanced solid tumours.MethodsPatients received single doses of intravenous pevonedistat 8 mg m−2, alone and with fluconazole (loading: 400 mg; maintenance: 200 mg once daily), or pevonedistat 8, 15 or 20 mg m−2, alone and with itraconazole 200 mg once daily. Serial blood samples for pevonedistat pharmacokinetics were obtained pre‐ and post‐infusion on days 1 (alone) and 8 (with fluconazole/itraconazole). After completing the pharmacokinetic portion, patients remaining on study received pevonedistat with docetaxel or carboplatin and paclitaxel.ResultsThe ratios of geometric mean area under the concentration–time curves (n; 90% confidence interval) of pevonedistat in the presence vs. absence of fluconazole or itraconazole were 1.11 (12; 1.03–1.19) and 1.14 (33; 1.07–1.23), respectively. Fifty patients (98%) experienced at least one adverse event (AE), with maximum severity of grade 1–2 in 28 patients (55%) and of grade ≥3 in 22 patients (43%). The most common drug‐related AEs were vomiting (12%), diarrhoea (10%) and nausea (8%). No new safety findings were observed for pevonedistat.ConclusionsFluconazole or itraconazole had insignificant effects on pevonedistat pharmacokinetics, indicating minor contributions of CYP3A/P‐gp to pevonedistat clearance. The safety profile of single doses of pevonedistat plus steady‐state fluconazole or itraconazole was consistent with prior clinical experience, with no new safety signals observed.
Change in the developmental fate of the chick optic vesicle from the neural retina to the telencephalon
Authors: Shirahama Misaki , Steinfeld Ichie , Karaiwa Akari , Taketani Shigeru , Vogel‐Höpker Astrid , Layer Paul G. , Araki Masasuke 
Published: March 2019

AbstractThe forebrain develops into the telencephalon, diencephalon, and optic vesicle (OV). The OV further develops into the optic cup, the inner and outer layers of which develop into the neural retina and retinal pigmented epithelium (RPE), respectively. We studied the change in fate of the OV by using embryonic transplantation and explant culture methods. OVs excised from 10‐somite stage chick embryos were freed from surrounding tissues (the surface ectoderm and mesenchyme) and were transplanted back to their original position in host embryos. Expression of neural retina‐specific genes, such as Rax and Vsx2 (Chx10), was downregulated in the transplants. Instead, expression of the telencephalon‐specific gene Emx1 emerged in the proximal region of the transplants, and in the distal part of the transplants close to the epidermis, expression of an RPE‐specific gene Mitf was observed. Explant culture studies showed that when OVs were cultured alone, Rax was continuously expressed regardless of surrounding tissues (mesenchyme and epidermis). When OVs without surrounding tissues were cultured in close contact with the anterior forebrain, Rax expression became downregulated in the explants, and Emx1 expression became upregulated. These findings indicate that chick OVs at stage 10 are bi‐potential with respect to their developmental fates, either for the neural retina or for the telencephalon, and that the surrounding tissues have a pivotal role in their actual fates. An in vitro tissue culture model suggests that under the influence of the anterior forebrain and/or its surrounding tissues, the OV changes its fate from the retina to the telencephalon.
Impacts of freshwater aquaculture on fish communities: A whole‐ecosystem experimental approach
Authors: Rennie Michael D. , Kennedy Patrick J. , Mills Kenneth H. , Rodgers Chandra M.C. , Charles Colin , Hrenchuk Lee E. , Chalanchuk Sandra , Blanchfield Paul J. , Paterson Michael J. , Podemski Cheryl L. 
Published: March 2019

Abstract

Aquaculture is a growing global industry; freshwater aquaculture has significant potential for expansion in Canada, but growth of the freshwater sector has been slow due to concerns over potential environmental impacts and a lack of information on potential impacts to native fish communities.

To provide guidelines and target variables for evaluating aquaculture impacts on freshwater fish communities, we operated an experimental aquaculture farm as a whole‐lake experiment where 10,000 rainbow trout (Oncorhynchus mykiss) were raised annually from 2003 to 2007. Impacts were assessed using up to 8 years of pre‐impact and 8–10 years of post‐impact data.

Prey fish abundance increased dramatically during aquaculture but declined sharply following the experiment. High abundance of littoral minnows in autumn was not observed during spring and, combined with size distribution data, suggests high overwinter mortality of adult minnows. White sucker (Catostomus commersonii) abundance and body condition declined during and after aquaculture, with evidence of overwinter juvenile recruitment failure in the last 2 years of operation, although size‐at‐age increased.

The adult abundance of lake trout (Salvelinus namaycush) doubled during aquaculture, due to a combination of (a) increased growth rates of young trout and (b) earlier age and larger sizes at maturation. Within 2 years following aquaculture, lake trout abundance declined by nearly 50% to background levels, suggesting a large increase in lake trout mortality once operations ceased. These changes were not observed in nearby reference lakes.

While aquaculture appeared to benefit some species (slimy sculpin [Cottus cognatus], minnows, lake trout), prolonged declines in white sucker abundance and condition and continued depression of Mysis densities and optimal oxythermal habitat availability nearly a decade following operations suggest potentially long‐term impacts at this magnitude. Importantly, this experiment highlights important indicator species and life history traits for monitoring of freshwater aquaculture impacts on native fish communities.
Drought ecohydrology alters the structure and function of benthic invertebrate communities in mountain streams
Authors: Herbst David B. , Cooper Scott D. , Medhurst Robert Bruce , Wiseman Sheila W. , Hunsaker Carolyn T. 
Published: March 2019

AbstractWe studied benthic macroinvertebrate communities in 12 mid‐elevation mountain streams in the Sierra Nevada, California. Data were collected at nine times (seven springs and two autumns) over a 14‐year period of variable hydrological conditions, including years of flood and extreme unprecedented drought.The taxonomic and trait structures of communities were similar during wet and average springs but became increasingly different as drought continued and smaller streams became intermittent.The density of total invertebrates, primarily chironomids, increased during the drought years, but the richness and abundance of mayfly, stonefly, and caddisfly (EPT) taxa declined during the late drought. During the late drought, the proportions of rheophilic, semivoltine taxa with clinger or swimmer behavioural habits decreased, whereas small, stress‐tolerant taxa with burrower and climber habits increased. Collector–gatherers dominated in all periods, but during the severe drought the relative abundance of micropredators increased and filterers, shredders, and grazers decreased.We also found greater changes in community structure between spring runoff and autumn base flow conditions in an average than a wet year. However, spring to autumn population growth rates were much greater during the wet than average year.Invertebrate richness and EPT abundance decreased and community structure showed large changes when stream discharge fell below 1–10 L/s, but remained relatively constant across a range of higher flows. During the severe drought, there were significant declines in the densities of 40% of the common EPT taxa compared to average and wet years, but chironomid, mite, and other invertebrate taxa showed variable responses.Invertebrate diversity, community structure, and ecosystem functions in small, headwater streams are especially vulnerable to drought conditions, which are expected to increase in frequency and intensity with climate change in the Sierra Nevada and other mountainous regions.
Introducing Transport “Surprises” in the Classroom: The Visible Fracture
Authors: Cardiff Michael , Heinle Ben 
Published: March 2019

AbstractHeterogeneity in aquifer properties, and the influence of transport processes other than advection and dispersion, often produce transport “surprises” in that measurements become difficult to reconcile with predictions from the traditional advection‐dispersion equation (ADE) that students are introduced to early in their hydrogeology training. Students should be aware of and prepared for the reasons why the ADE (as commonly applied) may not always “work” in the sense of generating valid predictions. Though the predictive limitations of the ADE have been frequently discussed in the hydrogeologic literature, our experience is that students are not appropriately skeptical of transport predictions. For this reason, we believe it is imperative that future generations of hydrogeologists are introduced to transport surprises early in their formative education. We present a laboratory activity, centered around a “Visible Fracture,” which was presented in a laboratory class period of 75 min. The Visible Fracture consists of two sheets of Plexiglas surrounding a heterogenous fluid‐filled aperture. Heated fluid is injected into the fracture, and thermochromic liquid crystal (TLC) materials are used to visualize the temperature both in the flowing fluid and in the surrounding Plexiglas “host rock.” Visualization of the plume shows the complex shapes that can be produced due to macroscopic heterogeneity. Tracer particles within the fracture allow students to examine heterogeneous local advective velocities, and to observe retardation of the fluid temperature plume. Student self‐reported knowledge surveys indicate greater conceptual understanding of transport non‐idealities after experiencing this activity.
Potentially beneficial effects of rhamnose on skin ageing: an in vitro and in vivo study
Authors: Pageon H. , Azouaoui A. , Zucchi H. , Ricois S. , Tran C. , Asselineau D. 
Published: March 2019

AbstractObjectiveRecent findings showed that skin ageing preferentially affects human papillary dermal fibroblasts suggesting that the papillary dermis represents a critical zone altered by skin ageing. Based on these findings, we investigated the potential anti‐ageing effect of rhamnose.MethodsWe investigated the potential anti‐ageing effect of rhamnose using in vitro reconstructed skin containing fibroblasts obtained either from young or old donors, and in vivo clinical investigation.ResultsWe detected positive effects of rhamnose in both epidermal and dermal compartments of in vitro reconstructed skin. Moreover, we were able to show that such in vitro findings were also obtained in vivo including an effect on collagen IV and procollagen I production.ConclusionWe provide evidence that rhamnose has a potentially beneficial effect on papillary dermis and dermal–epidermal junction, both of the areas which are affected by skin ageing.
Adaption, benefit and quality of care associated with primary nursing in an acute inpatient setting: A cross‐sectional descriptive study
Authors: Naef Rahel , Ernst Jutta , Petry Heidi 
Published: March 2019

AbstractAimsThe aim of this study was to investigate the adoption of primary nursing and to determine the quality of primary nurse‐led care in an acute inpatient setting.DesignDescriptive cross‐sectional study.MethodsParticipants included inpatients (N = 369) and nurses (N = 381). To assess adoption of primary nursing, patient records were analysed and an online survey of nurses was conducted from May–June 2017. To measure quality of nursing care, a structured questionnaire was administered to inpatients.ResultsPatients reported high quality of individualized, responsive and proficient care, but lower levels of coordinated care. Most nurses agreed that primary nursing is beneficial for person‐centred caring. However, only two‐thirds found that it was practiced on their unit and only half of care planning activities were attributable to primary nurses.ConclusionWhile perceived as beneficial, adoption of primary nursing in clinical practice remains partial. Hence, primary nursing may not be enough to ensure continuity and coordination of acute care.