bluuebunny/crossref_metadata_2025_split huggingface dataset:
Balanced Miscibility and Crystallinity by 2D Acceptors Enabled Halogen‐Free Solvent‐Processed Organic Solar Cells to Achieve 19.28% Efficiency
Authors: Lang Yongwen , Lai Hanjian , Fu Yuang , Ma Ruijie , Fong Patrick W. K. , Li Heng , Liu Kuan , Yang Xuechun , Lu Xinhui , Yang Tiangang , Li Gang , He Feng 
Published: November 2024

AbstractTwo highly crystalline 2D acceptors, ATIC‐C11 and ATIC‐BO, with acenaphthene‐expanded quinoxaline central cores, have been demonstrated with very different characteristics in ternary organic solar cells (OSCs). The difference in side chains induces their distinctive molecular packing mode and unique crystal structure, in which ATIC‐C11 displays a 3D structure with an elliptical framework, and ATIC‐BO gives a rectangular framework. Their high crystallinity contributes to organized molecular packing in ternary devices, thus low energetic disorder and suppressed energy loss. Through the analysis of morphology and carrier kinetics, it is found that ATIC‐BO's strong self‐aggregation and immiscibility induce large aggregates and severely impede charge transfer (CT) and dissociation. Conversely, ATIC‐C11's suitable crystallinity and compatibility positively regulate the crystalline kinetics during film formation, thus forming much‐ordered molecular packing and favorable phase separation size in blend films. As a result, ATIC‐C11‐based ternary devices achieve a high efficiency of 19.28% with potential in scalability and stability, which is the top‐ranking efficiency among nonhalogenated solvent‐processed OSCs. This work not only displays highly efficient and stable halogen‐free solvent‐processed organic photovoltaics (OPVs), but also offers a new thought for material design and selection rule on the third component in highly efficient ternary OSCs.
Hydrogen Bond‐Mediated Self‐Assembly of Carbon Dots Enabling Precise Tuning of Particle and Cluster Luminescence for Advanced Optoelectronic Applications
Authors: Ji Chunyu , Zeng Fanhao , Xu Wenjun , Zhu Minjie , Yu Hongchun , Yang Han , Peng Zhili 
Published: November 2024

AbstractThe effective control over the self‐assembly process of carbon dots (CDs) and their cluster luminescence in the aggregated state is of paramount significance and challenge. This study, for the first time, systematically explores the photoluminescent behavior of CDs in their aggregated state, which is less understood compared to their discrete state. By investigating the effects of concentration and solvent environment, it's demonstrated that CDs could exhibit dual emission properties, shifting from blue particle emissions to red cluster emissions as they aggregate. The key to this tunable luminescence lies in hydrogen bonding, which drives the self‐assembly of CDs and modulates their photo physical properties. These findings reveal that through precise control of aggregation, CDs can be engineered for advanced optoelectronic applications, including tunable light‐emitting diodes (LEDs), secure information encryption, and fingerprint authentication. This report not only deepens the understanding of the underlying mechanisms governing CDs' cluster luminescence but also introduces a novel approach to exploiting their unique properties for technological innovation.
Balancing the Charge Separation and Surface Reaction Dynamics in Twin‐Interface Photocatalysts for Solar‐to‐Hydrogen Production
Authors: Dan Meng , Yu Shan , Lin Weihua , Abdellah Mohamed , Guo Zhen , Liu Zhao‐Qing , Pullerits Tõnu , Zheng Kaibo , Zhou Ying 
Published: November 2024

AbstractSolar‐driven photocatalytic green hydrogen (H2) evolution reaction presents a promising route toward solar‐to‐chemical fuel conversion. However, its efficiency has been hindered by the desynchronization of fast photogenerated charge carriers and slow surface reaction kinetics. This work introduces a paradigm shift in photocatalyst design by focusing on the synchronization of charge transport and surface reactions through the use of twin structures as a unique platform. With CdS twin structure (CdS‐T) as a model, the role of twin boundaries in modulating surface reactions and facilitating charge migration is systematically investigated. Utilizing transient absorption (TA) and time‐resolved infrared (TRIR) spectroscopies, it is revealed that CdS‐T achieves charge separation on a picosecond timescale and, importantly, the surface reaction at the twin boundary with the involvement of holes also occurs within 100 ps to 3 ns. This synchronization of charge donation and surface regeneration significantly enhances the hydrogen evolution process. Accordingly, CdS‐T exhibits superior activity for visible light photocatalytic H2 production, withthe H2 production rate of 55.61 mmol h−1 g−1 and remarkable stability (>30 h), outperforming pristine CdS significantly. This study underscores the transformative potential of twin structures in photocatalysis, offering a new avenue to synchronize charge transport and surface reactions.
Advancing Human–Machine Interface (HMI) through Development of a Conductive‐Textile Based Capacitive Sensor
Authors: Tchantchane Rayane , Zhou Hao , Zhang Shen , Dunn Alexander , Sariyildiz Emre , Alici Gursel 
Published: November 2024

AbstractSmart wearable sensors in human–machine interfaces (HMI) facilitate communication and interface between humans and robots, as well as among humans. Conventional wearables face significant limitations, including performance degradation under various deformations (e.g., strain and pressure), limited stretchability and flexibility, poor comfort, and breathability, complicating their integration into HMI applications. In response to these limitations, a smart, sewable, high‐precision HMI device based on a soft, textile‐based sensor with machine learning (ML)‐assisted data processing is proposed. The (Ag)‐based fabric electrode integrated into polymeric composite dielectric layer, exhibiting hysteresis error of (≤4%), a tensile strain sensitivity of gauge factor (GF) ≃ 1.03 at 100% elongation, a pressure sensitivity of ≈1.583 × 10−2 kPa−1 at pressures (<50 kPa) and excellent stability (>1000 cycles). To demonstrate its versatility in HMI, the textile‐based sensor is integrated into a glove for real‐time control of a commercially available prosthetic hand and a drone, as well as for sign language recognition, achieving 95.4% classification accuracy using the random forest (RF) classifier across 10 gestures. Beyond gesture recognition, the sensor measures a range of subtle physiological activities (>0.35 kPa), functioning as a force myograph, esophageal manometry, and in gait analysis, among other strain and pressure‐related applications, highlighting exceptional capabilities for advanced wearable systems.
The Chemistry of α‐Enolizable Alkynones: A Comprehensive Review
Authors: Karnakova Sofia O. , Dvorko Marina Yu. , Shabalin Dmitrii A. 
Published: November 2024

AbstractThis comprehensive review summarizes the published literature data concerning the chemistry of α‐enolizable alkynones, also denoted aliphatic or C−H active alkynones, where an alkyl group is adjacent to the carbonyl function, from the first example in 1949 to the present day. Starting from a historical perspective, the reader will be introduced to the recent achievements and future challenges in this field. The review covers around 100 references.
Multifunctional Hydrogel Strategies for Myocardial Infarction: From Tissue Repair to Cardiac Regeneration
Authors: Lu Youze , Yang Shuqun , Yang Qiaoling , Huang Weiqiang 
Published: November 2024

AbstractMyocardial infarction (MI) remains the leading cause of death in patients with cardiovascular disease worldwide, with therapeutic approaches predominantly relying on medication, medical device implantation, and organ transplantation, each constrained by inherent limitations. Injectable hydrogels have recently emerged as promising therapeutic tools, noted for their biocompatibility, injectability, and capacity to provide mechanical support crucial for myocardial tissue repair. This review aims to comprehensively explore the interaction between injectable hydrogels and myocardial repair post‐infarction. It encompasses recent advancements in various types of injectable hydrogels used in MI therapy, including those modulating microenvironments, conducting electricity, influencing immunomodulation, promoting angiogenesis, and improving ischemia‐reperfusion conditions. By synthesizing current research findings, this review facilitates interdisciplinary knowledge integration and the development of effective prognostic indicators for injectable materials.
RNA‐Binding Protein Hnrnpa1 Triggers Daughter Cardiomyocyte Formation by Promoting Cardiomyocyte Dedifferentiation and Cell Cycle Activity in a Post‐Transcriptional Manner
Authors: Li Chuling , Chen Yijin , Chen Qiqi , Huang Haoxiang , Hesse Michael , Zhou Yilin , Jin Ming , Liu Yu , Ruan Yifei , He Xiang , Wei Guoquan , Zheng Hao , Huang Senlin , Chen Guojun , Liao Wangjun , Liao Yulin , Chen Yanmei , Bin Jianping 
Published: November 2024

AbstractStimulating cardiomyocyte (CM) dedifferentiation and cell cycle activity (DACCA) is essential for triggering daughter CM formation. In addition to transcriptional processes, RNA‐binding proteins (RBPs) are emerging as crucial post‐transcriptional players in regulating CM DACCA. However, whether post‐transcriptional regulation of CM DACCA by RBPs could effectively trigger daughter CM formation remains unknown. By performing integrated bioinformatic analysis of snRNA‐seq data from neonatal and adult hearts, this study identified Hnrnpa1 as a potential RBP regulating CM DACCA. Hnrnpa1 expression decreased significantly during postnatal heart development. With the use of α‐MHC‐H2B‐mCh/CAG‐eGFP‐anillin transgenic mice, Hnrnpa1 overexpression promoted CM DACCA, thereby triggering daughter CM formation and enhancing cardiac repair after myocardial infarction (MI). In contrast, CRISPR/Cas9 technology is used to generate CM‐specific Hnrnpa1 knockout mice. Hnrnpa1 knockout inhibited cardiac regeneration and worsened cardiac function in the neonatal MI model. Nanopore RNA sequencing, RIP assay, IP‐MS, MeRIP‐qPCR, PAR‐CLIP and luciferase reporter experiments showed that Hnrnpa1 induced Mettl3 post‐transcriptional splicing to inhibit m6A‐dependent Pbx1 and E2F1 degradation, thereby increasing Runx1, Ccne1, Cdk2 and Ccnb2 expression to promote CM DACCA. In conclusion, Hnrnpa1 triggered daughter CM formation by promoting CM DACCA in a post‐transcriptional manner, indicating that Hnrnpa1 might serve as a promising target in cardiac repair post‐MI.
Free Cholesterol‐Induced Liver Injury in Non‐Alcoholic Fatty Liver Disease: Mechanisms and a Therapeutic Intervention Using Dihydrotanshinone I
Authors: Shou Jia‐Wen , Ma Juncai , Wang Xuchu , Li Xiao‐Xiao , Chen Shu‐Cheng , Kang Byung‐Ho , Shaw Pang‐Chui 
Published: November 2024

AbstractBuild‐up of free cholesterol (FC) substantially contributes to the development and severity of non‐alcoholic fatty liver disease (NAFLD). Here, we investigate the specific mechanism by which FC induces liver injury in NAFLD and propose a novel therapeutic approach using dihydrotanshinone I (DhT). Rather than cholesterol ester (CE), we observed elevated levels of total cholesterol, FC, and alanine transaminase (ALT) in NAFLD patients and high‐cholesterol diet‐induced NAFLD mice compared to those in healthy controls. The FC level demonstrated a positive correlation with the ALT level in both patients and mice. Mechanistic studies revealed that FC elevated reactive oxygen species level, impaired the function of lysosomes, and disrupted lipophagy process, consequently inducing cell apoptosis. We then found that DhT protected mice on an HCD diet, independent of gut microbiota. DhT functioned as a potent ligand for peroxisome proliferator‐activated receptor α (PPARα), stimulating its transcriptional function and enhancing catalase expression to lower reactive oxygen species (ROS) level. Notably, the protective effect of DhT was nullified in mice with hepatic PPARα knockdown. Thus, these findings are the first to report the detrimental role of FC in NAFLD, which could lead to the development of new treatment strategies for NAFLD by leveraging the therapeutic potential of DhT and PPARα pathway.
Colorimetric Thermography by a Long‐Infrared Dual‐Band Metalens
Authors: Luo Zhendong , Zhang Peng , Hou Huwang , Li Yiming , Li Binzhao , Yi Yanji , Xu Lianjie , Meng Ting , Geng Zihan , Chen Mu Ku , Zhao Yang 
Published: November 2024

AbstractInfrared (IR) radiation thermography is extensively utilized in diverse fields due to its non‐contact capability. Nevertheless, its effectiveness is often compromised by the significant emissivity variations among different objects, limiting its application to specific setups or focused object types. Colorimetric thermography is introduced as an alternative emissivity‐independent method of radiation thermometry. This technique involves measuring radiance across two or more spectral bands and calculating the object's temperature based on the signal ratio, thereby mitigating emissivity effects under certain conditions. However, this method has the trade‐off of necessitating bulky optical systems, complex filter imaging configurations, and sensor structures. To meet the requirements of IR thermography for compact structure, lightweight design, and customizability, a dual‐band metalens is developed for the IR colorimetric thermography. The central wavelengths targeted are 9.5 and 12.5 µm. The dual‐band IR imaging by the fabricated dual‐band metalens is demonstrated, and the colorimetric thermography of low‐emissivity objects is performed without presetting emissivity values. This approach significantly eliminates measurement errors associated with emissivity by an average of 50.16% across a temperature range of 60–180 °C. This innovation paves the way for dynamic and multi‐target thermography using compact IR systems in complex environments.
Advances in Metal Halide Perovskite Memristors: A Review from a Co‐Design Perspective
Authors: Jiang Bowen , Chen Xiang , Pan Xiaoxin , Tao Li , Huang Yuangqiang , Tang Jiahao , Li Xiaoqing , Wang Peixiong , Ma Guokun , Zhang Jun , Wang Hao 
Published: November 2024

AbstractThe memristor has recently demonstrated considerable potential in the field of large‐scale data information processing. Metal halide perovskites (MHPs) have emerged as the leading contenders for memristors due to their sensitive optoelectronic response, low power consumption, and ability to be prepared at low temperatures. This work presents a comprehensive enumeration and analysis of the predominant research advancements in mechanisms of resistance switch (RS) behaviors in MHPs‐based memristors, along with a summary of useful characterization techniques. The impact of diverse optimization techniques on the functionality of perovskite memristors is examined and synthesized. Additionally, the potential of MHPs memristors in data processing, physical encryption devices, artificial synapses, and brain‐like computing advancement of MHPs memristors is evaluated. This review can prove a valuable reference point for the future development of perovskite memristors applications. In conclusion, the current challenges and prospects of MHPs‐based memristors are discussed in order to provide insights into potential avenues for the development of next‐generation information storage technologies and biomimetic applications.
Single‐Cell Membrane Potential Stimulation and Recording by an Electrolyte‐Gated Organic Field‐Effect Transistor
Authors: Lago Nicolò , Galli Alessandra , Tonello Sarah , Ruiz‐Molina Sara , Marino Saralea , Casalini Stefano , Buonomo Marco , Pisu Simona , Mas‐Torrent Marta , Giorgi Giada , Pedersen Morten Gram , Bortolozzi Mario , Cester Andrea 
Published: November 2024

AbstractThe reliable stimulation and recording of electrical activity in single cells by means of organic bio‐electronics will be an important milestone in developing new low‐cost and highly biocompatible medical devices. This paper demonstrates extracellular voltage stimulation and single‐cell membrane potential recording by means of a dual‐gate electrolyte‐gated organic field‐effect transistors (EGOFET) employing 2,8‐Difluoro‐5,11‐bis(triethylsilylethynyl)anthradithiophene blended with polystyrene as active material. To obtain a sufficiently small footprint to allow bidirectional communication at the single cell level, the EGOFET technology has been scaled down implementing a Corbino layout, paving the way to the development of novel bidirectional Electrocorticography (ECoG) devices with a high spatial resolution. A specific and thorough analysis of the working mechanisms of EGOFET‐based bio‐sensors is reported, highlighting the importance of the device design and using an appropriate batch of measurements for the recording of the electrical activity of cells.
Three timepoint perioperative CEA levels are a prognostic factor for recurrence after adjuvant chemotherapy in patients with Stage II and III colorectal cancer
Authors: Mizuno Shodai , Shigeta Kohei , Hara Ryosuke , Sakamoto Kyoko , Nakadai Jumpei , Baba Hideo , Kikuchi Hiroto , Adachi Yoko , Shimada Takehiro , Suzumura Hirofumi , Sugiura Kiyoaki , Matsui Shimpei , Seishima Ryo , Okabayashi Koji , Kitagawa Yuko 
Published: November 2024

AbstractAimTo investigate the relationship between the three timepoint perioperative CEA (ttpCEA) calculated at three timepoints and recurrence during the perioperative period in Stage II and III colorectal cancer (CRC) patients.MethodsWe performed a multi‐institutional retrospective analysis of patients with Stage II and III CRC who underwent surgery and adjuvant chemotherapy from 2010 to 2020. Patient data from three facilities were used as training data, and data from three other facilities were used as validation data. The primary endpoint was the time to recurrence (TTR).ResultsA total of 538 patients were included for the training data. To validate the feasibility of ttpCEA, 329 patients were included for the validation data. Training data patients were categorized as ttpCEA low (n = 365) and ttpCEA high (n = 173). The 5‐y TTR was significantly greater in the ttpCEA‐low subgroup than in the ttpCEA‐high subgroup (84.3% vs. 69.6%, respectively; p < 0.001). Validation data patients were categorized as ttpCEA low (n = 221) and ttpCEA high (n = 108). The 5‐y TTR was significantly greater in the ttpCEA‐low subgroup than in the ttpCEA‐high subgroup (82.9% vs. 68.7%, respectively; p = 0.003).ConclusionThe ttpCEA calculated from perioperative CEA levels at different timepoints was a prognostic factor for recurrence in Stage II and III CRC patients who underwent adjuvant chemotherapy according to both the training and validation data.
Long‐term effects of collaborative dementia care on quality of life and caregiver well‐being
Authors: Possin Katherine L. , Dulaney Sarah , Sideman Alissa B. , Wood Andrew J. , Allen I. Elaine , Bonasera Stephen J. , Merrilees Jennifer J. , Lee Kirby , Chiong Winston , Braley Tamara L. , Hooper Sarah , Kanzawa Mia , Gearhart Rosalie , Medsger Helen , Harrison Krista L. , Hunt Lauren J. , Kiekhofer Rachel E. , Chow Christopher , Miller Bruce L. , Guterman Elan L. 
Published: November 2024

AbstractINTRODUCTIONCollaborative dementia care models with care navigation, including the Care Ecosystem, improve outcomes for persons living with dementia (PLWDs) and their caregivers. The effects of continuous care over long periods have not been studied.METHODSIn this randomized clinical trial with 456 PLWD–caregiver dyads with high caregiver burden, we evaluated the cumulative 5‐year treatment effect on PLWD quality of life, health care utilization, caregiver depression, self‐efficacy, and burden.RESULTSFive‐year participation was associated with higher quality of life, lower caregiver depression, and higher caregiver self‐efficacy (all p’s < 0.05) with a trend for lower burden (p = 0.07). Treatment effects were most robust during the first 2 years. The effects on emergency department visits and hospitalizations were not significant.DISCUSSIONThe benefits of collaborative dementia care on PLWD quality of life and caregiver well‐being are sustained for 5 years, and the dyads may experience the greatest benefit during the first 2 years.Highlights
Collaborative dementia care with care navigation was evaluated over 5 years using a randomized clinical trial.
The care was associated with better quality of life for the person with dementia and well‐being for the caregiver.
The most robust treatment effects were in the first 2 years.
Homocysteine, neurodegenerative biomarkers, and APOE ε4 in neurodegenerative diseases
Authors: Lin William Z. , Yu Di , Xiong Lisa Y. , Zebarth Julia , Wang Ruoding , Fischer Corinne E. , Rajji Tarek K. , Tang‐Wai David F. , Tartaglia Carmela , Saposnik Gustavo , Swartz Richard H. , Grimes David A. , Lang Anthony E. , Hegele Robert A. , Farhan Sali , Ramirez Joel , Symons Sean , Goubran Maged , Binns Malcolm A. , Lou Wendy , Dixon Roger A. , Orange Joseph B. , Roberts Angela C. , Troyer Angela K. , Zetterberg Henrik , Herrmann Nathan , Rabin Jennifer S. , MacIntosh Bradley J. , Masellis Mario , Lanctôt Krista L. , Black Sandra E. , Swardfager Walter ,   the ONDRI Investigators
Published: November 2024

AbstractINTRODUCTIONElevated plasma homocysteine (Hcy) is associated with an increased risk of developing neurodegenerative diseases; however, its relationship with the apolipoprotein E (APOE) ε4 allele has not been well characterized.METHODSParticipants clinically diagnosed with Alzheimer's disease or mild cognitive impairment (AD/MCI), frontotemporal dementia, Parkinson's disease, or cerebrovascular disease were stratified by the presence of the APOE ε4 allele. Volumetric magnetic resonance imaging, plasma amyloid/tau/neurodegeneration biomarkers, and cognitive performance were quantified.RESULTSAcross all diagnostic groups, Hcy was associated with lower brain parenchymal fraction and greater neurofilament light chain in APOE ε4 non‐carriers only. In AD/MCI, Hcy was associated with phosphorylated tau 217 in APOE ε4 non‐carriers, but not in carriers. Exploratory analyses revealed interactions between Hcy and APOE ε4 on memory and visuospatial function.DISCUSSIONHcy may contribute to neurodegeneration depending on the presence of the APOE ε4 allele and specific disease processes. Trials on vitamin B12 supplementation may consider stratifying by APOE genotype.Highlights
Homocysteine (Hcy) was associated with neurodegenerative biomarkers across disease groups.
Relationships with Hcy were predominantly found in apolipoprotein E (APOE) ε4 non‐carriers.
In Alzheimer's disease, associations between Hcy and phosphorylated tau 217 were found in APOE ε4 non‐carriers only.
Significant interactions existed between Hcy and APOE ε4 status on cognition.
Iodid‐Anion ermöglicht eine reduktive Kreuz‐Elektrophil‐Kupplung zur Herstellung tertiärer Amine
Authors: Lemmerer Miran , Tona Veronica , Just David , Vavrík Miloš , Maryasin Boris , Di Mauro Giovanni , B. zur Bonsen Andreas , Kaiser Daniel , Maulide Nuno 
Published: November 2024

AbstractDie Reduktionskraft des Iodid‐Anions ist eine wenig erforschte Eigenschaft, die für die Kreuzkupplung elektrophiler, organischer Moleküle genutzt werden kann. Hier machen wir uns diese Eigenschaft zunutze, um tertiäre Amine durch die Kombination zweier einfacher Reagenzien herzustellen. Dabei handelt es sich um ein elektrophiles Kohlenstoffedukt und ein Iminiumiodid, das eine Doppelrolle erfüllt – sowohl als stickstoffhaltiger Baustein, als auch als Reduktionsmittel. Der zugrundeliegende Mechanismus dieses neuen Paradigmas der C−C‐Bindungsbildung wurde durch eine Kombination aus Experimenten und quantenchemischen Berechnungen untersucht.