bluuebunny/crossref_metadata_2025_split huggingface dataset:
USP11 Enhances TGFβ-Induced Epithelial–Mesenchymal Plasticity and Human Breast Cancer Metastasis
Authors: Garcia Daniel A. , Baek Christina , Estrada M. Valeria , Tysl Tiffani , Bennett Eric J. , Yang Jing , Chang John T. 
Published: May 2018

Abstract
Epithelial–mesenchymal transition (EMT) is a conserved cellular plasticity program that is reactivated in carcinoma cells and drives metastasis. Although EMT is well studied its regulatory mechanisms remain unclear. Therefore, to identify novel regulators of EMT, a data mining approach was taken using published microarray data and a group of deubiquitinases (DUB) were found to be upregulated in cells that have undergone EMT. Here, it is demonstrated that one DUB, ubiquitin-specific peptidase 11 (USP11), enhances TGFβ-induced EMT and self-renewal in immortalized human mammary epithelial cells. Furthermore, modulating USP11 expression in human breast cancer cells altered the migratory capacity in vitro and metastasis in vivo. Moreover, elevated USP11 expression in human breast cancer patient clinical specimens correlated with decreased survival. Mechanistically, modulating USP11 expression altered the stability of TGFβ receptor type II (TGFBR2) and TGFβ downstream signaling in human breast cancer cells. Together, these data suggest that deubiquitination of TGFBR2 by USP11 effectively spares TGFBR2 from proteasomal degradation to promote EMT and metastasis.
Implications: USP11 regulates TGFβ-induced epithelial–mesenchymal plasticity and human breast cancer metastasis and may be a potential therapeutic target for breast cancer. Mol Cancer Res; 16(7); 1172–84. ©2018 AACR.
AHNAK Loss in Mice Promotes Type II Pneumocyte Hyperplasia and Lung Tumor Development
Authors: Park Jun Won , Kim Il Yong , Choi Ji Won , Lim Hee Jung , Shin Jae Hoon , Kim Yo Na , Lee Seo Hyun , Son Yeri , Sohn Mira , Woo Jong Kyu , Jeong Joseph H. , Lee Cheolju , Bae Yun Soo , Seong Je Kyung 
Published: May 2018

Abstract
AHNAK is known to be a tumor suppressor in breast cancer due to its ability to activate the TGFβ signaling pathway. However, the role of AHNAK in lung tumor development and progression remains unknown. Here, the Ahnak gene was disrupted to determine its effect on lung tumorigenesis and the mechanism by which it triggers lung tumor development was investigated. First, AHNAK protein expression was determined to be decreased in human lung adenocarcinomas compared with matched nonneoplastic lung tissues. Then, Ahnak−/− mice were used to investigate the role of AHNAK in pulmonary tumorigenesis. Ahnak−/− mice showed increased lung volume and thicker alveolar walls with type II pneumocyte hyperplasia. Most importantly, approximately 20% of aged Ahnak−/− mice developed lung tumors, and Ahnak−/− mice were more susceptible to urethane-induced pulmonary carcinogenesis than wild-type mice. Mechanistically, Ahnak deficiency promotes the cell growth of lung epithelial cells by suppressing the TGFβ signaling pathway. In addition, increased numbers of M2-like alveolar macrophages (AM) were observed in Ahnak−/− lungs, and the depletion of AMs in Ahnak−/− lungs alleviated lung hyperplastic lesions, suggesting that M2-like AMs promoted the progression of lung hyperplastic lesions in Ahnak-null mice. Collectively, AHNAK suppresses type II pneumocyte proliferation and inhibits tumor-promoting M2 alternative activation of macrophages in mouse lung tissue. These results suggest that AHNAK functions as a novel tumor suppressor in lung cancer.
Implications: The tumor suppressor function of AHNAK, in murine lungs, occurs by suppressing alveolar epithelial cell proliferation and modulating lung microenvironment. Mol Cancer Res; 16(8); 1287–98. ©2018 AACR.
Coronary Artery Remodeling and Fibrosis With Continuous-Flow Left Ventricular Assist Device Support
Authors: Ambardekar Amrut V. , Weiser-Evans Mary C.M. , Li Marcella , Purohit Suneet N. , Aftab Muhammad , Reece T. Brett , Moulton Karen S. 
Published: May 2018

Background:
Coronary artery fluid dynamics may be altered because of the nonphysiological flow seen in continuous-flow left ventricular assist devices (CF-LVADs). Our aim was to study the structure and composition of coronary vessels after CF-LVAD.

Methods and Results:
Coronary arteries were collected from patients with heart failure (HF) at the time of transplantation, of whom 15 were supported with a CF-LVAD before transplant (HF+LVAD group) and 9 were not (HF non-LVAD group). In addition, coronary samples were obtained from 5 nonfailing age-matched donors (nonfailing group). Histological analysis was performed to quantify coronary morphology, composition, vascular fibrosis, and vasa vasorum density. The age and sex mix of the 3 groups were similar, and the mean duration of LVAD support was 213 days. Compared with patients with HF and nonfailing donors, the arteries from patients with HF+LVAD had expansion of the adventitia, breakdown of the internal elastic lamina, and increased adventitial collagen deposition and density of vasa vasorum.

Conclusions:
Among patients supported with CF-LVADs, the coronary arteries develop marked remodeling with increased adventitial fibrosis. The physiological consequences of these structural changes are unknown, but it is possible that arterial contractility may be impaired, thus limiting coronary flow reserve and promoting myocardial ischemia. This may contribute to CF-LVAD complications, such as ventricular arrhythmias and right ventricular failure. As more patients receive CF-LVADs and new pump technology attempts to modulate flow profiles and pulsatility, further research is needed to understand the mechanisms and long-term sequela of these changes in coronary arteries and other vascular beds.
Sociolinguistic Indexicalities in Ethnic Diversity
Authors: Stell Gerald 
Published: May 2018

Abstract
Ethnicity and language have often been considered jointly on the grounds of their intrinsic interrelation: hard ethnic boundaries are manifested by the use of heritage languages, while dynamics of assimilation reduce the need to linguistically project ethnic distinctness. This article seeks to test the interrelation between patterns of language use and ethnic boundaries in the context of Suriname by analyzing perceptions of ethnolinguistic boundaries elicited from a sample of young informants from Paramaribo. The findings suggest that Surinamese ethnic boundaries are salient, albeit eroding in urban areas. Erosion is visible at a linguistic level in what seems to be a general shift in urban areas toward Dutch and Sranan Tongo. However, this shift might be proceeding at different paces from one ethnic group to the next. As a result, ethnicity is reflected in variable levels of linguistic competence in Dutch and Sranan Tongo.
On the Characteristics of Linear-Phase Roll Vortices under a Moving Hurricane Boundary Layer
Authors: Gao Kun , Ginis Isaac 
Published: May 2018

Abstract
Previous theoretical and numerical studies only focused on the formation of roll vortices (rolls) under a stationary and axisymmetric hurricane. The effect of the asymmetric wind structure induced by the storm movement on the roll characteristics remains unknown. In this study, we present the first attempt to investigate the characteristics of linear-phase rolls under a moving hurricane by embedding a linear two-dimensional (2D) roll-resolving model into a 3D hurricane boundary layer model. It is found that the roll horizontal wavelength under the moving hurricane is largely determined by the radial-shear-layer depth, defined as the thickness of the layer with positive radial wind shear. The horizontal distribution of the roll wavelength resembles the asymmetric pattern of the radial-shear-layer depth. Interestingly, the roll growth rate is not only affected by the radial wind shear magnitude alluded to in previous studies but also by the radial-shear-layer depth. A deeper (shallower) radial shear layer tends to decrease (increase) the roll growth rate. Such an effect is due to the presence of the bottom boundary. The bottom boundary constrains the lower-level roll streamlines and reduces the efficiency of rolls in extracting kinetic energy from the radial shear. This effect is more pronounced under a deeper shear layer, which favors the formation of larger-size rolls. This study improves the understanding of the main factors affecting the structure and growth of rolls and will provide guidance for interpreting the spatial distribution of rolls under realistic hurricanes in observations and high-resolution simulations.
Mechanisms Governing the Development of the North Atlantic Warming Hole in the CESM-LE Future Climate Simulations
Authors: Gervais Melissa , Shaman Jeffrey , Kushnir Yochanan 
Published: May 2018

AbstractA warming deficit in North Atlantic sea surface temperatures is a striking feature in global climate model future projections. This North Atlantic warming hole has been related to a slowing of the Atlantic meridional overturning circulation (AMOC); however, the detailed mechanisms involved in its generation remain an open question. An analysis of the Community Earth System Model Large Ensemble simulations is conducted to obtain further insight into the development of the warming hole and its relationship to the AMOC. It is shown that increasing freshwater fluxes through the Arctic gates lead to surface freshening and reduced Labrador Sea deep convection, which in turn act to cool Labrador Sea sea surface temperatures. Furthermore, the resulting changes in surface ocean circulation lead to enhanced transport of cooled Labrador Sea surface waters into the interior of the subpolar gyre and a more zonal orientation of the North Atlantic Current. As a result, there is an increase in ocean advective heat flux divergence within the center of the subpolar gyre, causing this warming deficit in North Atlantic sea surface temperatures. These local changes to the ocean circulation affect the AMOC and lead to its slowdown.
Can thrombophilia predict recurrent catheter-related deep vein thrombosis in children?
Authors: Avila M. Laura , Amiri Nour , Stanojevic Sanja , Vu Trang T. , Barron Katherine , Krol Peter , Yue Natasha , Williams Suzan , Brandão Leonardo R. 
Published: May 2018

Key Points
Thrombophilia was not predictive of recurrent catheter-related deep vein thrombosis in children. Young age at the time of catheter insertion and lack of administration of anticoagulation were predictive of recurrent events.
High NPM1-mutant allele burden at diagnosis predicts unfavorable outcomes in de novo AML
Authors: Patel Sanjay S. , Kuo Frank C. , Gibson Christopher J. , Steensma David P. , Soiffer Robert J. , Alyea Edwin P. , Chen Yi-Bin A. , Fathi Amir T. , Graubert Timothy A. , Brunner Andrew M. , Wadleigh Martha , Stone Richard M. , DeAngelo Daniel J. , Nardi Valentina , Hasserjian Robert P. , Weinberg Olga K. 
Published: May 2018

Key Points
High NPM1-mutant allele burden at diagnosis is associated with poor clinical outcome in de novo AML. The adverse effect of high NPM1-mutant allele burden is independent of comutations and clinical variables.
A viagem redonda: habeas data, direitos constitucionais e as provas ilícitas
Authors: Barroso Luis Roberto 
Published: May 2018

I. Introdução. II- A efetividade das normas constitucionais. III- Direitos subjetivos constitucionais e as ações constitucionais. IV - O habeas data. V - Um novo desvio: a tolerância com as provas ilícitas.
A qualitative exploration of evidence-based decision making in public health practice and policy: the perceived usefulness of a diabetes economic model for decision makers
Authors: Grove Amy , Sanders Tom , Salway Sarah , Goyder Elizabeth , Hampshaw Susan 
Published: May 2018

Purpose
The purpose of this paper is to explore the perceived usefulness of a diabetes economic model as a potential tool for aiding evidence-based decision making in public health.

Methods
Fifteen interviews and two focus groups, with four participants in each, were conducted with health and management professionals working in one public health department in a local council. Data were analysed using inductive thematic analysis to generate four themes.

Findings
The findings reflect attitudes and beliefs of a diverse staff group situated in public health services. Findings reveal that the economic model was perceived as useful and participants reported positive views regarding the principles of economic modelling for decision making. However, it was potentially problematic in practice due to organisational constraints linked to limited resources, restricted budgets and local priorities. Differences in institutional logics of staff working across public health and local government departments were identified as a potential barrier to the use of the model in practice.

Discussion
The findings highlight anticipated challenges that public health practice and policy decision-makers could face if they selected to implement an economic modelling approach to fulfil their evidence needs. Previous studies have revealed that healthcare decision makers would find evidence around the economic impacts of public health interventions useful, but this information was not always available in the format required. This paper provides insights into how public health staff perceive economic modelling, and explores how they use this type of evidence when making public health practice and policy decisions.
To live in light: Historical conversations in Michael John LaChiusa’s The Wild Party
Authors: Robinson Joshua 
Published: May 2018

Abstract
Michael John LaChiusa’s The Wild Party is notable for any number of reasons, particularly given that it was one of two adaptations of the John Moncure March poem premiering in New York City during the 1999–2000 season, the other being Andrew Lippa’s adaptation at Manhattan Theatre Club. LaChiusa’s adaptation is also notable for its racialized narrative, given that the central role of Queenie was recast, replacing an actress of colour – singer-actress Vanessa Williams – with a white actress, Oscar nominee Toni Collette. In this article, the implications of this casting change are explored, particularly the ways in which the change from an actress of colour to a white actress forced the musical into a historical conversation with the racialized conventions of vaudeville performance.
Book Reviews
Authors: Graziano John , Cooper Tom , Marshall Elsa 
Published: May 2018

Abstract

The Yeoman of the Guard, Arthur Sullivan, Critical Edition, Colin Jagger (ed.) (2016)
Oxford: Oxford University Press, 456 pp.,
ISBN: 9780193413139, p/bk, £67.50

Actor-Musicianship, Jeremy Harrison (2016)
London: Bloomsbury Methuen Drama, 220 pp.,
ISBN: 9781472509635, p/bk, £21.99

New York City and the Hollywood Musical: Dancing in the Streets, Martha Shearer (2016)
London: Palgrave Macmillan, 230 pp.,
ISBN: 9781137569370, h/bk, £67.99
Association between oxygen saturation and critical congenital heart disease in newborns
Authors: Halim Lidia , Ali Muhammad , Sembiring Tiangsa 
Published: May 2018

Background Critical congenital heart disease (CCHD) is relatively common, with a prevalence of 6-8 in every 1,000 live births. This congenital anomaly is a newborn condition that would be ideally suited for a screening program, if simple and reliable methods were available. Pulse oximetry (PO) has been proposed as a screening method to detect CCHD.
Objective To assess for a possible association between decreased oxygen saturation and CCHD in newborns.
Methods We conducted a cross-sectional study from March 2014 to February 2015 in several hospitals in North Sumatra. Healthy, full term and post-term newborns aged 2 to 72 hours underwent pulse oximetry measurements on the right hand and one of the lower extremities. If oxygen saturation (SpO2) was ≤ 95%, the measurement was repeated 2 more times. Subjects also underwent echocardiography.
Results A total of 386 newborns underwent SpO2 measurements: 377 newborns had SpO2 > 95% and 9 newborns had SpO2 ≤ 95%. Of the infants with SpO2 > 95%, 297 were excluded because their parents refused echocardiography examination. Thus, 80 newborns with SpO2 > 95% and 9 newborns with SpO2 ≤ 95% underwent echocardiography. Echocardiography revealed that 5 of 9 newborns with SpO2 ≤ 95% suffered from Tetralogy of Fallot (ToF) (3 subjects) and transposition of the great arteries (TGA) (2 subjects). One infant with SpO2 > 95% had ventricular septal defect (VSD), as detected by echocardiography. Oxygen saturation ≤ 95% had significant association with CCHD (P<0.001).
Conclusion Decreased oxygen saturation has a significant association with critical congenital heart disease in newborns.
A revision of Sagriva (Hemiptera: Heteroptera: Dinidoridae)
Authors: Rédei Dávid 
Published: May 2018

Abstract
The Indomalayan genus Sagriva Spinola, 1850 (Hemiptera: Heteroptera: Dinidoridae: Dinidorinae) is revised. The identity of its single previously valid species, S. vittata Spinola, 1850, is clarified based on the relevant type material, the species is diagnosed, illustrated, and recorded for the first time from Thailand and Laos. A new species, Sagriva banna sp. nov., is described from Yunnan Province of China and Yen Bai Province of Vietnam.
Periscelis fugax sp. nov., an overlooked European species of Periscelididae (Diptera), with notes on the morphology and terminology of terminalia
Authors: Roháček Jindřich , Andrade Rui 
Published: May 2018

Abstract
Periscelis (Periscelis) fugax sp. nov. is described and illustrated based on series of specimens from Portugal and the Czech Republic. It is probably widespread in Europe but has not been previously recognized from the closely related and externally very similar P. (P.) winnertzii Egger, 1862. The new species differs from P. winnertzii not only in structures of the male and female terminalia (illustrated) but also in colour pattern of pedicel and mesonotum. Morphology of the male and female terminalia is studied in detail in both these species and terminology of their structures is discussed and redefined. A new modern key to Palaearctic species of Periscelis (s. str.) species is constructed.
Tinea altaica sp. nov. and new records of some small moths from the Russian Altai (Lepidoptera: Meessiidae, Tineidae, Douglasiidae, Epermeniidae, Glyphipterigidae: Acrolepiinae)
Authors: Gaedike Reinhard , Šumpich Jan 
Published: May 2018

Abstract
The paper summarizes the results of our study of selected Microlepidoptera families (Meessiidae, Tineidae, Douglasiidae, Epermeniidae, Glyphipterigidae: Acrolepiinae) collected in the Russian Altai. Tinea altaica sp. nov. is described from the vicinity of Tashanta on the Russian-Mongolian border and from Mongolia. The new species distantly resembles Tinea semifulvella Haworth, 1828 and T. semifulvelloides Petersen, 1973. The up to now unknown females of Klimeschia biarmatella Budashkin, 2003 and Monopis luteocostalis Gaedike, 2006 are described. Scardia boletella (Fabricius, 1794), Crassicornella crassicornella (Zeller, 1847), Trichophaga ziniella Zagulajev, 1960, Tineola bisselliella (Hummel, 1823), Monopis laevigella (Denis & Schiffermüller, 1775), M. pallidella Zagulajev, 1955, Epermenia ochreomaculella asiatica Gaedike, 1979, and Acrolepiopsis sapporensis (Matsumura, 1931) are recorded from the Altai Republic for the first time. Tinea hongorella Zagulajev, 1975 and Klimeschia biarmatella Budashkin, 2003, so far known only from the holotypes, are new species for Russia. Tinea hongorella is also a new species for Europe.
Histeridae of Socotra (Coleoptera: Histeroidea)
Authors: Lackner Tomáš , Vienna Pierpaolo 
Published: May 2018

Abstract
The histerid beetles (Coleoptera: Histeridae) of Socotra Island (Yemen) are reviewed based on the material collected during the Czech expeditions undertaken between 2000 and 2012. A total of 20 species are recorded, three of which are described herein: Pachycraerus socotrensis sp. nov., Liopygus occidentalis sp. nov., and Teretrius (Neoteretrius) dispar sp. nov. Hypocaccus virescens Thérond, 1963 is transferred from the subgenus Baeckmanniolus Reichardt, 1926 to Hypocaccus s. str. Thomson, 1867 based on external morphology. Most taxa, albeit determined only up to their (sub)generic rank, are recorded from Socotra for the first time. Due to poor understanding of their taxonomy, or lack of determination keys to the following (sub)genera: Tribalus Erichson, 1834, Plegaderus (Plegaderus) Erichson, 1834, Acritus (Acritus) LeConte, 1853, and Teretrius (Teretrius) Erichson, 1834, their representatives from Socotra are left without identification pending revisions. The Socotran histerid fauna has been found to consist mainly of widely distributed African, Arabian/Near Eastern taxa, as well as local endemics. The occurrence of the (predominantly Holarctic) genus Plegaderus and the exclusively southeast Asian genus Liopygus Lewis, 1891 in Socotra is highly interesting.
Used Furan Sand Reclamation in REGMAS Vibratory Unit
Authors: Dańko J. , Dańko R. , Skrzyński M. 
Published: May 2018

Abstract
The paper, especially dealt with problems of reclamation of used furan sand, carried out in new, vibratory sand reclamation unit REGMAS developed by researches from AGH-University of Science and Technology, Faculty of Foundry Engineering in Cracow (Poland). Functional characteristics of reclamation unit as well as the results of reclamation of used sand with furfuryl resin are discussed in the paper. The quality of reclaim was tested by means of the LOI and pH value, dust content in the reclaim and at least by the the quality of the castings produced in moulds prepared with the use of reclaimed matrix.
Properties of AlSi9Mg Alloy Matrix Composite Reinforced with Short Carbon Fibre after Remelting
Authors: Łągiewka M. , Konopka Z. 
Published: May 2018

Abstract
The presented work describes the results of examination of the mechanical properties of castings made either of AlSi9Mg alloy matrix composite reinforced with short carbon fibre or of the pure AlSi9Mg alloy. The tensile strength, the yield strength, Young’s modulus, and the unit elongation were examined both for initial castings and for castings made of the remelted composite or AlSi9Mg alloy. After preparing metallographic specimens, the structure of the remelted materials was assessed. A few non-metallic inclusions were observed in the structure of the remelted composite, not occurring in the initial castings. Mechanical testing revealed that all the examined properties of the initial composite material exceed those of the non-reinforced matrix. A decrease in mechanical properties was stated both for the metal matrix and for the composite after the remelting process, but this decrease was so slight that it either does not preclude them from further use or does not restrict the range of their application.
A Survey on Differential Geometry of Riemannian Maps Between
Authors: Şahin Bayram 
Published: May 2018

AbstractThe main aim of this paper is to state recent results in Riemannian geometry obtained by the existence of a Riemannian map between Riemannian manifolds and to introduce certain geometric objects along such maps which allow one to use the techniques of submanifolds or Riemannian submersions for Riemannian maps. The paper also contains several open problems related to the research area.
Generalized Sasaki Metrics on Tangent Bundles
Authors: Vaisman Izu 
Published: May 2018

Abstract
We define a class of metrics that extend the Sasaki metric of the tangent manifold of a Riemannian manifold. The new metrics are obtained by the transfer of the generalized (pseudo-)Riemannian metrics of the pullback bundle π−1(TM⊕T*M), where π : T M → M is the natural projection. We obtain the expression of the transferred metric and define a canonical metric connection with torsion. We calculate the torsion, curvature and Ricci curvature of this connection and give a few applications of the results. We also discuss the transfer of generalized complex and generalized Kähler structures from the pullback bundle to the tangent manifold.