bluuebunny/crossref_metadata_2025_split huggingface dataset:
Quality of life, depression and anxiety in cerebral amyloid angiopathy: A cross‐sectional study
Authors: Kaushik Kanishk , Waslam Natasha G. , van der Zwet Reinier G. J. , Voigt Sabine , van Dort Rosemarie , van Zwet Erik W. , Terwindt Gisela M. , van Etten Ellis S. , Wermer Marieke J. H. 
Published: November 2024

AbstractBackground and PurposeData on health‐related quality of life (HRQoL) and mood in cerebral amyloid angiopathy (CAA), a disease characterized by stroke and cognitive decline, are limited. We aimed to investigate the impacted domains of life, value‐based HRQoL and the prevalence of depression and anxiety in patients with CAA.MethodsWe conducted a cross‐sectional study of patients with sporadic (s)CAA, lobar dominant mixed CAA and hypertensive arteriopathy (mixed CAA‐HTA), or Dutch‐type hereditary (D‐)CAA, from prospective outpatient clinic cohorts. Participants completed four questionnaires: the EuroQoL 5 dimensions 5‐level questionnaire (EQ‐5D‐5L; EQ‐VAS for visual analogue scale; EQ‐Index for index rating), the Short‐Form 36 questionnaire (SF‐36), the Center for Epidemiologic Studies—Depression scale (CES‐D), and the Hospital Anxiety and Depression Scale (HADS; ‐D for depression and ‐A for anxiety subscales). The EQ‐5D‐5L assesses the domains mobility, self‐care, usual activities, pain/discomfort and anxiety/depression. The SF‐36 domains are physical functioning, social functioning, physical role limitations, emotional role limitations, mental health, vitality, bodily pain, and general health perceptions. We compared age‐ and sex‐ adjusted HRQoL (SF‐36 domain scores; EQ‐VAS; EQ‐Index) to the Dutch normative population, and estimated the prevalences of current depression (either: history of depression or current use of antidepressants, with high score on CES‐D [≥16] and/or HADS‐D [≥8]; or high score on both depression questionnaires) and anxiety (HADS‐A ≥ 8).ResultsWe included 179 patients: 77 with sCAA (mean age: 72 years, women: 36%), 31 with mixed CAA‐HTA (68 years, women: 29%), and 71 with D‐CAA (56 years, women: 52%, symptomatic: 35 [49%]). The SF‐36 profiles of all patient groups were similar, negatively differing from the norm in emotional role functioning, social functioning and vitality. The EQ‐VAS score of patients (mean [SD] sCAA: 76 [16], D‐CAA: 77 [15]) was similar to the norm, as was the EQ‐Index score. Fifteen patients with sCAA (23%; 95% confidence interval [CI] 13%–33%), seven with mixed CAA‐HTA (27%; 95% CI 10%–44%) and eight with D‐CAA (14%; 95% CI 5%–22%) were noted as having depression. The prevalences of anxiety and depression were equivalent.ConclusionsWe found that CAA influenced emotional role functioning and aspects linked to social engagement consistently across its subtypes. One quarter of patients exhibited depressive or anxiety symptoms. Recognizing these impacted domains could enhance overall well‐being.
The chemoreceptor controlling the Wsp‐like transduction pathway in Halomonas titanicaeKHS3 binds and responds to purine derivatives
Authors: Ramos Ricciuti Fernando E. , Soldano Anabel , Herrera Seitz M. Karina , Gasperotti Ana F. , Boyko Alexandra , Jung Kirsten , Bellinzoni Marco , Lisa María‐Natalia , Studdert Claudia A. 
Published: November 2024

The chemosensory pathway HtChe2 from the marine bacterium Halomonas titanicae KHS3 controls the activity of a diguanylate cyclase. Constitutive activation of this pathway results in colony morphology alterations and an increased ability to form biofilm. Such characteristics resemble the behavior of the Wsp pathway of Pseudomonas. In this work, we investigate the specificity of Htc10, the only chemoreceptor coded within the HtChe2 gene cluster. The purine derivatives guanine and hypoxanthine were identified as ligands of the recombinantly produced Htc10 ligand‐binding domain, with dissociation constants in the micromolar range, and its structure was solved by X‐ray protein crystallography. The sensor domain of Htc10 adopts a double Cache folding, with ligands bound to the membrane‐distal pocket. A high‐resolution structure of the occupied guanine‐binding pocket allowed the identification of residues involved in ligand recognition. Such residues were validated by site‐directed mutagenesis and isothermal titration calorimetry analyses of the protein variants. Moreover, heterologous expression of Htc10 in a Pseudomonas putida mutant lacking the native Wsp chemoreceptor promoted biofilm formation, a phenotype that was further enhanced by Htc10‐specific ligands. To our knowledge, this is the first description of binding specificity of a chemoreceptor that controls the activity of an associated diguanylate cyclase, opening the way for dynamic studies of the signaling behavior of this kind of sensory complex.
Through Their Eyes: Using Photovoice to Capture the Capacity‐Building Journey of Long Covid Patient Experts
Authors: Natafgi Nabil , Parris Katie , Walker Erin , Gartner Tracey , Coffin Jeanette , Mitcham Ariana , Ferrer Luis Sanchez , Patel Maushmi K. , Wymbs Haley , Kennedy Ann Blair 
Published: November 2024

ABSTRACTBackgroundLong Covid, characterised by persistent symptoms following the coronavirus disease 2019 (COVID‐19) infection, significantly impacts the quality of life. Engaging patients in research and care through participatory methods can enhance a shared understanding of illness and improve the relevance of research.ObjectiveWe define Patient Experts (PEs) as persons (including patients, caregivers and providers) who have completed a series of training sessions on team building, research methods and communication at the Patient Engagement Studio, University of South Carolina (PES USC). This study explores the use of photovoice to document the experiences and capacity‐building journey of Long Covid PEs within PES USC.MethodsThe study employed photovoice within the COVID‐19‐Focused Virtual Patient Engagement Studio (CoVIP Studio). PEs submitted photographs and narratives at two distinct time points. Among the 18 PEs who participated in the project, 47 photos were collected during the training, and 31 were collected at the project's conclusion. Thematic analysis was conducted to capture changes in patient perspectives and engagement.ResultsInitial themes identified were “Hope through Community,” “Collaborative Education and Research” and “Strength and Endurance.” By the project's end, themes had evolved to “Working as a Team to Share and Acquire Knowledge,” “Enhanced Confidence in the Future of Care” and “Perseverance and Progress.” These findings highlight the transformative impact of patient engagement and the utility of photovoice in documenting longitudinal shifts in patient perspectives.ConclusionPhotovoice effectively engaged Long Covid patients and captured their evolving roles and perceptions as PEs. The study underscores the value of patient‐led participatory methods in enhancing the relevance and applicability of clinical research, advocating for their broader adoption to improve patient‐centred care and research outcomes.Patient or Public ContributionA CoVIP Studio stakeholder advisory board (CoVIP SAB) guided the co‐development and implementation of this project. The CoVIP SAB comprised nine members with complementary skills and expertise, including three patients, three clinicians who provide care to patients with COVID‐19 and three researchers with expertise in patient‐centred research, COVID‐19 and/or patient engagement and collaborate with patients as co‐investigators. The board contributed to project design and implementation, refining photovoice prompts and shaping dissemination strategies. In addition, one PE who actively participated in all phases of the project contributed to the writing of this paper and is a coauthor. All project activities involved patients and/or caregivers with lived experience of Long Covid.
Insights into structural and proteomic alterations related to pH‐induced changes and protein deamidation in hair
Authors: Adav Sunil S. , Wu Alicia Rosabee Yu Ling , Ng Kee Woei 
Published: November 2024

AbstractObjectivesThe hair shaft is often exposed to shampoo and haircare products that have unknown or varying pH levels. These products contain a combination of surfactants and other active ingredients to treat the hair or the scalp. As amphoteric proteins, hair keratins have limited buffering capacity, so variations in pH can have multifaceted impacts on them. However, there is limited knowledge about how pH affects keratins and keratin‐associated proteins (KAPs). Therefore, this study aims to examine the effects of varying pH levels (pH 3–pH 12) on hair structure and analyse consequent alterations in the hair proteome using mass spectrometry‐based proteomics.MethodsA scanning electron microscope was used to examine changes in hair‐shaft morphology due to exposure to various pH levels, while mass spectrometry was employed to analyse protein alterations.ResultsWe found that exposing the hair shaft to varying pH levels led to specific effects on the cuticle, including cuticle lifting at certain pH levels, while proteomics analysis identified alterations in the hair proteome along with significant deamidation of keratins types I and II and KAPs. More pronounced effects were observed at extreme acidic conditions (pH 3) and alkaline conditions (above pH 8) on both hair morphology and hair proteins. pH levels between pH 5 and pH 7 had minimal impact on hair structure and proteins, suggesting that haircare products with pH in this range are ideal for hair‐shaft health. In contrast, alkaline pH levels were found to negatively affect hair.ConclusionsThe structure evaluation and proteomics data emphasize the critical role of pH in hair health. The extreme acidic or alkaline pH impacts the hair structure and hair proteins. The study highlights the optimal pH range for maintaining healthy hair.
Association Between Toothbrushing Habits and Self‐Rated Oral Health: Re‐Consideration of the 3‐3‐3 Toothbrushing Campaign
Authors: Lee Yu‐Rim , Jeong Jin‐Young , Lee Hwa‐Young , Shin Sun‐Jung , Park Hee‐Jung , Kim Nam‐Hee 
Published: November 2024

ABSTRACTObjectivesThis study investigates the association between toothbrushing frequency and self‐rated oral health to evaluate the effectiveness of the 3‐3‐3 toothbrushing campaign.MethodsEmploying a cross‐sectional study design, we analysed responses from 13,199 adults using structured questionnaires. The dependent variable was self‐rated oral health. The independent variables were toothbrushing habits. We compared both groups; control group: twice a day and case group: three times a day. Predisposing, enabling and need factors were adjusted as confounders based on the Anderson behaviour model.ResultsOur findings reveal no significant correlation between toothbrushing frequency (twice vs. three times daily) and self‐perceived oral health status. These results suggest re‐evaluating the 3‐3‐3 campaign's recommendations. Further research is necessary to identify factors that more directly influence self‐rated oral health.ConclusionOur research found that increasing toothbrushing from twice to three times daily does not significantly enhance oral health, as evidenced by an odds ratio of 0.97 and a negligible Cohen's d value. We recommend public health campaigns emphasise toothbrushing quality over frequency to improve oral health outcomes.
Toxicity manifestations encountered in peptide receptor radionuclide therapy setting
Authors: Parghane Rahul V. , Basu Sandip 
Published: November 2024

AbstractPeptide receptor radionuclide therapy (PRRT) has demonstrated immense promise as a treatment for patients with neuroendocrine tumors (NET) who have somatostatin receptor (SSTR) expression. PRRT significantly reduces tumor growth, stabilizes the disease, and prolongs survival in a significant percentage of patients with metastatic/advanced NET. It produces an important beneficial effect on the quality of life (QOL) and effectively alleviates symptoms in patients with NET. Overall, PRRT is typically well‐tolerated and most of the side effects are usually transient and subside on their own. It is, however, crucial to be cognizant of the potential toxicities associated with this treatment. This awareness will enable physicians to promptly detect, effectively manage, and prevent these toxicities by identifying high‐risk factors in NET patients. This review provides an in‐depth overview for clinicians managing NET about the toxicity of PRRT. The toxicities are stratified into acute, subacute, and long‐term based on their onset following PRRT. Potential high‐risk factors in order to treat effectively and prevent these toxicities in NET patients are presented including the management strategy. This review also discusses novel insights, perspectives, and recent advancements in predicting, preventing, and managing toxicity associated with PRRT, while offering prospective future research directions to minimize clinical toxicity and maximize the therapeutic benefits of PRRT as a treatment strategy for NET patients.
Using acoustic monitoring to reveal nearly year‐round presence of humpback whales (Megaptera novaeangliae) in the waters of southern Iceland
Authors: Chicco Carola , Papale Elena , Wensveen Paul J. , Mouy Xavier , Samarra Filipa I. P. 
Published: November 2024

AbstractIcelandic waters are a crucial feeding ground for North Atlantic humpback whales, yet their occurrence in these subarctic waters remains underexplored. This study examined seasonal and diel patterns in humpback whale occurrence off the Vestmannaeyjar archipelago, southern Iceland, from June 2018 to May 2019, using automated acoustic detections from bottom‐moored hydrophones. Vocalizations were manually categorized into social calls, song fragments, or songs. Further classification identified seven social sound types and 25 unique song units. Humpback whales were detected on 126 out of 329 recording days and were present in nearly all months except April and May. Social calls were most common in summer and fall, while song fragments and songs were prevalent in winter. No diel singing pattern was observed. These findings suggest southern Iceland serves as a vital habitat for humpback whales, acting as a feeding ground in summer and a migration stopover or overwintering site in winter. The study underscores the potential of acoustic monitoring to uncover important habitats year‐round, especially when field observations are scarce, and emphasizes the need for ongoing monitoring of habitat use. Continued acoustic monitoring could provide further insights into the whales' behavioral patterns and preferences, essential for their conservation.
Hyoid Bone Position and Upper Airway Morphology of Children With Obstructive Sleep Apnea: A Systematic Review and Meta‐analysis
Authors: Li Yaqi , Zhao Tingting , Ngan Peter , Yi Susu , Wei Zeyu , Hua Fang , He Hong 
Published: November 2024

ABSTRACTThe objective of this systematic review was to summarise the existing evidence regarding hyoid bone position and upper airway morphology of children with obstructive sleep apnea (OSA). Electronic searches were carried out in PubMed, Embase, Web of Science, CINAHL and WorldCat databases without any restrictions on language from inception to March 2024. The studies which compared the hyoid bone position and upper airway morphology using lateral cephalograms between children with and without OSA will be included. The methodological quality of the included studies was assessed using Newcastle‐Ottawa Scale, and the meta‐analysis was conducted utilising random‐effects model. Twelve cross‐sectional studies and one case–control study were included. One study was rated as low quality, three as medium quality, five as high quality, and four as very high quality. Meta‐analysis showed that compared to healthy children, children with OSA tended to have increased distance between hyoid bone and mandibular plane (Hy‐MP, MD: 3.33, 95% CI: 1.90 to 4.77, p < 0.00001, I2 = 72%), increased distance between hyoid bone and cervical vertebra (Hy‐C3, MD: 1.54, 95% CI: 0.62 to 2.46, p = 0.001, I2 = 68%), and a smaller airway space behind the soft palate (U‐MPW, MD: −3.07, 95% CI: −4.76 to −1.38, p = 0.0004, I2 = 68%). Whereas there was no significant difference in inferior posterior airway space between children with OSA and healthy controls (IPAS, MD: −1.51, 95% CI: −3.37 to 0.35, p = 0.11, I2 = 71%). In children with OSA, the hyoid bone may exhibit a more anterior and inferior position and the airway posterior to the soft palate demonstrated a narrower dimension. Registration: PROSPERO (CRD42024528171)
Neutrophil Extracellular Traps in Oral Diseases
Authors: Gao Pengfei , Zhou Jun , Sun Lu , Liu Dayong 
Published: November 2024

ABSTRACTObjectiveTo summarize the current knowledge of the neutrophil extracellular traps (NETs) and its critical role in various oral diseases.MethodsWe reviewed the recent research on NETs through PubMed and Web of Science. An analysis of recent research results was summarized from three aspects: NETs induction and formation, functions of NETs, and NETs in oral diseases.ResultsThe relationship between neutrophils and NETs is critical to the body's defense against microbial invasion. NETs can effectively combat pathogens with an anti‐inflammatory effect and meanwhile it can contribute to inflammation. Moreover, it can synergize with other immune cells to respond to stimuli, such as pathogens, host‐derived mediators, and drugs. It was revealed that NETs play different roles to influence various oral diseases like periodontitis, endodontic infection, oral mucosal diseases, maxillofacial tumors, and many other oral diseases.ConclusionThe balance between the protective and potentially harmful effects of NETs is a key factor in determining the outcome of infections and inflammatory responses. The role of NETs in oral diseases needs to be further studied to enable better understanding of its role in the different oral diseases.
Myopia control strategies: A systematic review and meta‐meta‐analysis
Authors: Zaabaar Ebenezer , Asiamah Randy , Kyei Samuel , Ankamah Samuel 
Published: November 2024

AbstractPurposeTo summarise pooled estimates of the efficacies of various myopia control interventions, as drawn from published meta‐analyses.MethodPubMed, SCOPUS and Web of Science were searched from inception to February 2024 for systematic reviews and meta‐analyses reporting treatment effects of various myopia control strategies. The qualities of the included meta‐analyses were assessed using the 16‐item A MeaSurement Tool to Assess systematic Reviews (AMSTAR) 2. An intervention was defined as having a clinically significant effect if it resulted in a change in spherical equivalent refraction (SER) of ≥0.50 D/year or axial length (AL) change of ≤−0.18 mm/year.ResultsA total of 38 studies were identified. The overall respective changes in SER and AL, mean difference (95% CI) were high‐concentration (≥0.5%) atropine 0.67 D (0.58–0.77) and −0.24 mm (−0.36 to −0.11); moderate‐concentration (>0.05% to <0.5%) atropine 0.48 D (0.34–0.62) and −0.23 mm (−0.27 to −0.19); low‐concentration (0.01%, 0.025%, 0.05%) atropine 0.33 D (0.23–0.43) and −0.14 mm (−0.19 to −0.09); orthokeratology −0.47 mm (−0.66 to −0.28); peripheral plus soft contact lenses 0.30 D (0.18–0.42) and −0.35 mm (−0.62 to −0.08); peripheral plus spectacles 0.77 D (0.40–1.14) and −0.43 mm (−0.78 to −0.08); multifocal spectacles 0.21 D (0.11–0.31); repeated low‐level red light therapy 0.55 D (0.46–0.65) and −0.25 mm (−0.29 to −0.20); outdoor time 0.17 D (0.16–0.18) and −0.04 mm (−0.06 to −0.01).ConclusionHigh and moderate concentrations of atropine, orthokeratology, peripheral plus spectacles and repeated low‐level red light demonstrated clinically significant effects on slowing AL elongation, while high and moderate concentrations of atropine, peripheral plus spectacles and repeated low‐level red light demonstrated clinically significant effects on slowing SER progression.
Specific Features of Modeling Nanofluid Flows (a Review)
Authors: Rudyak V. Ya. 
Published: November 2024

Abstract
Problems arising when modeling nanofluids are discussed. The possibility of using two- and one-fluid descriptions is analyzed. The thermophysical properties of nanofluids are reviewed and it is shown that their viscosity and thermal conductivity depend not only on the concentration of nanoparticles, but also on their size and material. The behavior of similarity parameters and their dependence on the concentration, size and material of nanoparticles are studied in detail. It is shown that in the general case it is impossible to solve the problem simply by varying the similarity parameters. Two examples of solving the problem of heat transfer of two different nanofluids, with conventional spherical nanoparticles and with carbon nanotubes, are given. In the latter case, the nanofluid is non-Newtonian. It has been shown that nanofluids make it possible to obtain very high values of excess of the heat transfer coefficient.
Is hip adductor or abductor strength in healthy athletes associated with future groin pain? A systematic review and meta-analysis
Authors: Quintana-Cepedal Marcos , Vicente-Rodríguez Germán , Crespo Irene , Olmedillas Hugo 
Published: November 2024

ObjectiveTo systematically review the association between hip adduction and abduction strength, and adduction-to-abduction strength ratio in healthy athletes with the occurrence of future groin pain and time-loss groin injuries.DesignSystematic review with meta-analysis.Data sourcesPubMed, Web of Science, SPORTDiscus, PEDro, Embase, and Scopus.Eligibility criteriaStudies included had to (1) measure hip adductor or abductor strength in healthy athletes, (2) conduct a follow-up period to assess the occurrence of groin pain, (3) present strength data separately for participants who remained uninjured and those who suffered an injury and (4) use a prospective design. Risk of bias was assessed according to the Quality in Prognosis Studies tool. The certainty in the evidence appraised was measured using the Grading of Recommendations Assessment Development and Evaluation approach.ResultsThirteen prospective cohort studies met the inclusion criteria. Overall study risk of bias was rated as low. Players who remained uninjured had stronger adduction strength compared with players who subsequently suffered groin pain (standardised mean differences with 95% CIs (SMD=−0.5, 95% CI −0.92 to −0.09)) and time-loss groin pain (SMD=−0.68, 95% CI −1.31 to −0.06). Trivial effects were observed for abduction strength (groin pain SMD=0.03, 95% CI −0.11 to 0.17; time-loss SMD=−0.07, 95% CI −0.25 to 0.11) and adduction-to-abduction strength ratio (groin pain SMD=−0.02, 95% CI −0.55 to 0.51; time-loss SMD=−0.11, 95% CI −1.11 to 0.89). Age and diagnostic criteria were not significant moderators of the relationship between adductor strength and groin pain (p=0.72 and p=0.12).ConclusionThere is a moderate effect of hip adductor strength on the occurrence of groin pain, while there is no relationship between either abductor strength or the ratio of adductor-to-abductor strength with the occurrence of groin pain.PROSPERO registration numberCRD42024548630.