bluuebunny/crossref_metadata_2025_split huggingface dataset:
(R)‐ and (S)‐ketamine induce differential fMRI responses in conscious rats
Authors: Masaki Yukiko , Kashiwagi Yuto , Watabe Hiroshi , Abe Kohji 
Published: August 2019

Abstract(R,S)‐ketamine exerts robust antidepressant effects in patients with depression when given at sub‐anesthetic doses. Each of the enantiomers in this racemic mixture, (R)‐ketamine and (S)‐ketamine, have been reported to exert antidepressant effects individually. However, the neuropharmacological effects of these enantiomers and the mechanisms underlying their antidepressive actions have not yet been fully elucidated. Therefore, we investigated the effect of (R,S)‐, (R)‐, and (S)‐ketamine on brain activity by functional MRI (fMRI) in conscious rats and compared these with that of N‐methyl‐D‐aspartate receptor (NMDAR) antagonist MK‐801 (n = 5~7). We also assessed their pharmacokinetic profiles (n = 4) and their behavioral effects (n = 7~9). This pharmacological MRI study revealed a significant positive response to (S)‐ketamine specifically in the cortex, nucleus accumbens and striatum. In contrast, negative fMRI responses were observed in various brain regions after (R)‐ketamine administration. (R,S)‐ketamine, evoked significant positive fMRI responses specifically in the cortex, nucleus accumbens and striatum, and this fMRI response pattern was comparable with that of (S)‐ketamine. MK‐801‐induced similar fMRI response pattern to (S)‐ketamine. The fMRI responses to (S)‐ketamine and MK‐801 showed differential temporal profiles, which corresponded with brain concentration profiles. (S)‐ketamine and MK‐801 significantly increased locomotor activity, while (R)‐ketamine produced no noticeable change. (R,S)‐ketamine tended to increase locomotor activity. Our novel fMRI findings show that (R)‐ketamine and (S)‐ketamine induce completely different fMRI response patterns on rat, and that the response produced by the latter is similar to that elicited by an NMDAR antagonist. Our findings provide insight into the antidepressant mechanism of (R,S)‐ketamine.
Drawing to reason and learn in science
Authors: Tytler Russell , Prain Vaughan , Aranda George , Ferguson Joseph , Gorur Radhika 
Published: August 2019

AbstractDespite mixed results in research on student learning from drawing in science, there is growing interest in the potential for this visual mode, in tandem with other modes, to enact and enable student reasoning in this subject. Building on current research in this field, and using a micro‐ethnographic approach informed by socio‐semiotic perspectives, we aimed to identify how and why student drawing can contribute to student reasoning and learning. In our study, secondary school students were challenged to explore and collaboratively create explanatory representations of phenomena including through drawing. Data were generated using multiple wall‐ and ceiling‐mounted cameras capable of continuously tracking groups of students negotiating these representational challenges. Our analysis proceeded through active and iterative viewing of the extensive video record, and the identification of themes to establish possible relationships between drawing and reasoning. Through this process, we (a) identify multiple necessary conditions and varied opportunities for student drawing to enact and enable reasoning, and (b) extend current understandings of how the particular affordances of this mode interact with these conditions to contribute to student learning in science.
A study of modal damping for offshore wind turbines considering soil properties and foundation types
Authors: Ishihara Takeshi , Wang Lilin 
Published: August 2019

AbstractThe modal damping ratio for each mode is crucial to characterize the dynamic behavior of offshore wind turbines and widely used by simulation software in wind turbine engineering, such as Bladed and FAST. In this study, modal damping ratios of offshore wind turbines are systematically studied for different soil properties and foundation types. Firstly, the modal damping ratios and modal frequencies for the first and second modes of a gravity foundation–supported offshore wind turbine are studied. An offshore wind turbine supported by a monopile foundation is then investigated to clarify the characteristics of modal damping ratios and modal frequencies for the monopile foundation. The soil parameters are identified by means of genetic algorithm (GA). Predicted modal damping ratios and modal frequencies as well as modal shapes show good agreement with the field measurements for both foundations. Finally, a sensitivity analysis study is carried out to investigate the effects of soil properties and foundation types on modal damping ratios. For the gravity foundation–supported offshore wind turbine, soil properties affect the modal damping ratio of the second mode largely, but affect that of the first mode little, while for the monopile‐supported offshore wind turbine, soil properties affect the modal damping ratios of the first and second modes significantly. Predicted natural periods and modal damping ratios of the first mode for both foundations by a pair of simple models agree well with those by numerical models.
Captive breeding of wildlife resources—China's revised supply‐side approach to conservation
Authors: Wang Wenxia , Yang Liangliang , Wronski Torsten , Chen Shaozhi , Hu Yanjie , Huang Songlin 
Published: August 2019

ABSTRACTThe conservation and utilization of wild animals in China often raises public concerns. Thus, the Chinese government is increasingly exploring sustainable development of wildlife resources, and has implemented a series of measures, such as the modification of the Wildlife Protection Law (WPL), implementation of captive breeding licenses, an animal marking system, forest certification, and other actions to regulate captive breeding and utilization of wildlife. At the same time, the government tries to meet the Chinese traditional demand for wildlife products. We first introduce wildlife utilization as an internationally accepted conservation tool, and describe market‐based wildlife farming as a legal substitute for wild‐hunted animals. Second, we highlight the importance of wildlife products in Chinese culture and economy and review some successful examples of wildlife utilization in China, showing that the supply‐side approach is a viable alternative to classical conservation. Subsequently, we outline benefits of, and drawbacks to, China's ‘conservation through utilization’ approach, resulting in the implementation of China's new, revised WPL. We discuss merits and shortcomings of China's revised WPL and respond to recent national and international criticism on China's supply‐side approach to conservation. We strongly propose that captive breeding is a feasible approach to China's wildlife conservation–utilization dilemma, and much work is needed to promote the progress, such as legislation restructure, government attention, duties clarification, and so on. © 2019 The Wildlife Society.
The Swampland Distance Conjecture and towers of tensionless branes
Authors: Font Anamaría , Herráez Alvaro , Ibáñez Luis E. 
Published: August 2019

AbstractThe Swampland Distance Conjecture states that at infinite distance in the scalar moduli space an infinite tower of particles become exponentially massless. We study this issue in the context of 4d type IIA and type IIB Calabi-Yau compactifications. We find that for large moduli not only towers of particles but also domain walls and strings become tensionless. We study in detail the case of type IIA and IIB 𝒩 = 1 CY orientifolds and show how for infinite Kähler and/or complex structure moduli towers of domain walls and strings become tensionless, depending on the particular direction in moduli space. For the type IIA case we construct the monodromy orbits of domain walls in detail. We study the structure of mass scales in these limits and find that these towers may occur at the same scale as the fundamental string scale or the KK scale making sometimes difficult an effective field theory description. The structure of IIA and IIB towers are consistent with mirror symmetry, as long as towers of exotic domain walls associated to non-geometric fluxes also appear. We briefly discuss the issue of emergence within this context and the possible implications for 4d vacua.
Rural–urban disparities in the prevalence of diabetes and diabetic eye complications in Hungary
Authors: Tóth Gábor , Szabó Dorottya , Sándor Gábor L , Szepessy Zsuzsanna , Barsi Árpád , Nagy Zoltán Zsolt , Limburg Hans , Németh János 
Published: August 2019

Summary
Background
To examine the rural–urban differences in the prevalence of diabetes mellitus (DM) and diabetic retinopathy (DR) in the population aged 50 years and older in Hungary.

Methods
105 clusters of 35 people aged 50 years or older were randomly selected. Standardized rapid assessment of avoidable blindness (RAAB) with the diabetic retinopathy module was performed. Participants were classified as diabetic if they had a previous diagnosis of DM or a random blood glucose level ≥200 mg/dl. Each individual with DM who agreed underwent dilated fundus examination and DR grading.

Results
The prevalence of DM was higher in rural (21.8%) than in urban (18.6%) areas (p = 0.016). The prevalence of DR did not differ significantly between rural and urban areas in DM cases. Blindness (0.9% vs. 0.1%; p = 0.048) and blindness due to DM (0.3% vs. 0.0%; p = 0.021) in diabetic participants was significantly more common in rural than in urban areas. Diabetic eye screening coverage was significantly lower in rural than in urban areas (p ≤ 0,007).

Conclusion
Based on our results and the high rate of blindness and blindness due to DR in rural areas, primary eye care should be improved and a telemedical eye screening program should be undertaken, especially concentrating on rural areas.
Absolutism, Relativism and Metaepistemology
Authors: Carter J. Adam , McKenna Robin 
Published: August 2019

AbstractThis paper is about two topics: metaepistemological absolutism and the epistemic principles governing perceptual warrant. Our aim is to highlight—by taking the debate between dogmatists and conservativists about perceptual warrant as a case study—a surprising and hitherto unnoticed problem with metaepistemological absolutism, at least as it has been influentially defended by Paul Boghossian (Fear of knowledge: against relativism and constructivism, Oxford University Press, Oxford, 2006a) as the principal metaepistemological contrast point to relativism. What we find is that the metaepistemological commitments at play on both sides of this dogmatism/conservativism debate do not line up with epistemic relativismnordo they line up with absolutism, at least as Boghossian articulates this position. What this case study reveals is the need in metaepistemological option space for the recognition of a weaker and less tendentious form of absolutism, what we call “environment relativism”. On this view, epistemic principles are knowable, objective, and they can serve as the basis of particular epistemic evaluations, but their validity is relative to the wider global environment in which they are applied.
A survey of challenges for runtime verification from advanced application domains (beyond software)
Authors: Sánchez César , Schneider Gerardo , Ahrendt Wolfgang , Bartocci Ezio , Bianculli Domenico , Colombo Christian , Falcone Yliès , Francalanza Adrian , Krstić Srđan , Lourenço Joa̋o M. , Nickovic Dejan , Pace Gordon J. , Rufino Jose , Signoles Julien , Traytel Dmitriy , Weiss Alexander 
Published: August 2019

AbstractRuntime verification is an area of formal methods that studies the dynamic analysis of execution traces against formal specifications. Typically, the two main activities in runtime verification efforts are the process of creating monitors from specifications, and the algorithms for the evaluation of traces against the generated monitors. Other activities involve the instrumentation of the system to generate the trace and the communication between the system under analysis and the monitor. Most of the applications in runtime verification have been focused on the dynamic analysis of software, even though there are many more potential applications to other computational devices and target systems. In this paper we present a collection of challenges for runtime verification extracted from concrete application domains, focusing on the difficulties that must be overcome to tackle these specific challenges. The computational models that characterize these domains require to devise new techniques beyond the current state of the art in runtime verification.
Construction of software using gain-schedule/auto-adaptive control strategy for automation in drilling fluid production plants
Authors: Magalhães S. C. , Fontella G. , Borges R. F. O. , Vega M. P. , Calçada L. A. , Scheid C. M. 
Published: August 2019

AbstractAlthough many advanced nonlinear process control techniques have been developed over the past decade, classic control based on feedback response still has its place. This is mostly so because feedback empirical control is robust and simple to implement and does not require fancy calculations or high-qualified operational manpower to operate it. This work has developed an application written in LabVIEW® environment capable of doing a fully automated single-input single-output control. Preliminary tests were performed in a drilling fluid production unit, controlling flow rate through manipulation of the pump power engine. In the future, tests in the same plant of pressure control by choke valves manipulation will be performed (as found in rig sites, where wellbore pressure is controlled by manipulation of such valves). The final goal is to implement such software in a real rig site, to help operators in drilling control areas such as flow rate and wellbore pressure. The produced software has embedded three self-developed features: automatic plant identification (API), auto-tuning (ABAP) and controllers auto-switch (CAS). The API determines automatically the linearity of the process determining the empirical parameters according to Sundaresan and Krishnaswamy technique. In sequence, it calculates the parameters for P, PI and PID controllers using Cohen–Coon and Ziegler–Nichols methods. The API method automates the sequence of tests necessary to implement the Sundaresan and Krishnaswamy empirical approach. The ABAP feature based on heuristic rules tunes in real time the controllers’ parameters to optimize its response. The CAS allows automatic switch between controllers and parameters to avoid instability, overshoots and creates a synergy with ABAP feature. The results have shown that the API feature is a good optimizer reducing the invested time to calculate all the parameters, from hours to a few minutes. The CAS results demonstrated an associative property with the ABAP feature to mitigate instabilities and overshoots. Therefore, the preliminary results suggested this software is a unique and important tool to improve performance, profitability and reliability during offshore and onshore drilling operations. Moreover, this application could be used in any industry with an approximate first-order dynamic system due to its robustness and a low human interaction need.
Laparoscopic pelvic organ suspension with mesh: a modified technique and primary results
Authors: Khodaei Shahin , Ghahramani Leila , Khazraei Hajar , Hosseini Seyed Vahid 
Published: August 2019

Abstract
Background Pelvic organ prolapse recurrence rate is an important issue which impacts the patient's quality of life and results in a new surgical procedure. We use a new technique of laparoscopic pelvic organ suspension (rectal suspension) for pelvic organ prolapse treatment in our center. We evaluated the results of this technique, three months after surgery and at the time of study reporting.
Methods All patients with pelvic organ prolapse for whom laparoscopic pelvic organ prolapse had been done were evaluated. Data were collected from the patient's charts and their short term follow up 3 months after the surgery and their last follow up visit. Demographic, history, physical examination, Wexner's fecal incontinence score and Altomare's Obstructed Defecation Syndrome score, post-operation complications and patient's satisfaction were analyzed, retrospectively.
Results All patients were female with a mean age of 57 ± 11.43 years (range 32–86 years). Mean BMI was 26.1 ± 3.73. Nine patients had rectal bleeding (31%), 18 had prolonged or difficult defecation (62%), 16 had rectal prolapse (55.2%), 11 had gas incontinence (37.9%), 9 had liquid stool incontinence (31%), 5 had stool incontinence (17.2%), 9 had vaginal prolapse (31%), 23 had constipation (79.3%), 9 complaint of pelvic pain (31%), 9 had urge or stress urinary incontinence (31%) and 13 had dyspareunia (44.8%).
Conclusions In conclusion, we believe this procedure has good results in short term follow up (3 months after surgery), but a high recurrence rate in the middle term follow up. Therefore, this procedure is no longer recommended.
Effects of Preoperative Atorvastatin Treatment On Erectile Function After Radical Prostatectomy: Results From a Subgroup of ESTO1, a Randomized, Double-Blind, Placebo-Controlled Study
Authors: Siltari Aino , Riikonen Jarno , Fode Mikkel , Murtola Teemu J. 
Published: August 2019

AbstractIntroductionErectile dysfunction is common after radical prostatectomy because of damage to the cavernous nerves. Thus, it is important to identify new ways to avoid this problem. For example, statins have shown positive effects on erectile function and may have anti-inflammatory effects that improve recovery after surgery.AimThe aim of this exploratory analysis of a subgroup from ESTO1, a randomized, double-blind, placebo-controlled study, was to evaluate the preoperative use of atorvastatin on erectile function after radical prostatectomy.MethodPatients were randomized to either 80 mg atorvastatin or placebo daily before undergoing radical prostatectomy from study inclusion to the day of surgery. Altogether 118 men with prostate cancer and scheduled for radical prostatectomy were asked to fill out the 5-item version of the International Index of Erectile Function (IIEF-5) questionnaire before surgery and at 3, 6, 9, and 12 months after surgery.Main Outcome MeasurementsThe study was exploratory, with the main outcome being the overall difference between IIEF-5 scores in the 2 groups at 12 months. Several hypotheses generating sub-analyses were conducted.ResultsOverall, 85% filled out the IIEF-5 questionnaire before their operation and 85%, 81%, 78%, and 78% completed it at 3, 6, 9, and 12 months follow-up, respectively. 52% of men had information available at all time points. There were no statistically significant differences between the groups at baseline in either erectile function, comorbidities, or tumor characteristics. The median duration of use of atorvastatin and placebo before surgery was 27 and 25 days, respectively. Preoperative atorvastatin treatment had no statistically significant effect on erectile function after prostatectomy as compared with placebo, although IIEF-5 scores were higher at all time points in the statin arm. Furthermore, atorvastatin treatment compared with placebo improved IIEF-5 scores at 12 months after surgery when the cavernous nerves were at least partially intact bilaterally (P &lt; .04, n = 65); however, after full bilateral or unilateral nerve-sparing, the difference was not statistically significant.Clinical ImplicationShort-term statin treatment did not improve recovery of erectile function after prostatectomy; however, further studies are needed before final conclusions.Strengths & LimitationsThis was a randomized placebo-controlled study. Original ESTO1 study was designed to detect a difference in prostate cancer biomarkers.ConclusionShort-term atorvastatin treatment before radical prostatectomy had no statistically significant effect on the recovery of erectile functions in a non-selected cohort of patients undergoing radical prostatectomy. Further studies will be needed to clarify the role of long-term atorvastatin use before and after prostatectomy.
The Persistence of Racialized Health Care Attitudes: Racial Attitudes among White Adults and Identity Importance among Black Adults
Authors: McCabe Katherine T. 
Published: August 2019

AbstractThis study evaluates the emergence and persistence of the racial divide on health reform in public opinion using survey data from 2008 through 2017. The findings support existing work showing a consistent relationship between racial resentment and attitudes on the Affordable Care Act among White adults. However, the study also builds on existing work by evaluating the relationship between strength of racial identity among Black adults and health care opinion during President Barack Obama's Administration. The paper investigates the implications of the findings for future health policy in the post-Obama era using survey data on the Republicans’ attempt to pass the American Health Care Act in 2017. The results underscore the conditions that make the “spillover” of racial attitudes into seemingly non-racial policy areas more or less likely to occur. The findings also provide suggestive evidence for how future health reforms may receive different levels of support from both White and Black adults.
Urine and plasma concentrations of amino acids and plasma vitamin status differ, and are differently affected by salmon intake, in obese Zucker fa/fa rats with impaired kidney function and in Long-Evans rats with healthy kidneys
Authors: Drotningsvik Aslaug , Midttun Øivind , Vikøren Linn Anja , McCann Adrian , Ueland Per Magne , Mellgren Gunnar , Gudbrandsen Oddrun Anita 
Published: August 2019

AbstractKidney function affects amino acid metabolism and vitamin status. The aims of the present study were to investigate urine and plasma concentrations of amino acids as well as plasma vitamin status in rats with impaired renal function (Zucker fa/fa rats) and in rats with normal kidney function (Long-Evans rats), and to explore the effects of salmon intake on these parameters and potential biomarkers of salmon intake in both rat strains. Male rats were fed diets with casein as sole protein source (control diet) or 25 % protein from baked salmon and 75 % casein for 4 weeks. Urine concentrations of markers of renal function and most amino acids and plasma concentrations of most vitamins were higher, and plasma concentrations of several amino acids including arginine, total glutathione and most tryptophan metabolites were lower in Zucker fa/fa rats compared with Long-Evans rats fed the control diet. Concentrations of kidney function markers were lower after salmon intake only in Zucker fa/fa rats. A trend towards lower urine concentrations of amino acids was seen in both rat strains fed the salmon diet, but this was more pronounced in Long-Evans rats and did not reflect the dietary amino acid content. Urine 1-methylhistidine, 3-methylhistidine, trimethylamineoxide and creatine concentrations, and plasma 1-methylhistidine and creatine concentrations were higher after salmon intake in both rat strains. To conclude, concentrations of amino acids in urine and plasma as well as vitamin status were different in Zucker fa/fa and Long-Evans rats, and the effects of salmon intake differed by rat strain for some of these parameters.