bluuebunny/crossref_metadata_2025_split huggingface dataset:
A randomised open label comparative study evaluating the effectiveness, adherence and safety between 2% mupirocin ointment and 2% fusidic acid cream in children with impetigo
Authors: Velappan Ravichandran , Ramasamy Sindhuja , Venu Shridhar , Chandrasekar Muthusubramanian 
Published: May 2019

<p class="abstract"><strong>Background:</strong> Impetigo is a superficial bacterial skin infection that affects mainly children, which is highly contagious. Topical anti-bacterials are most commonly used in both primary and secondary impetigo. Clinical trials have shown high efficacy of these topicals along with systemic antibiotics in both complicated and uncomplicated impetigo. However use of these topical modalities alone in uncomplicated primary impetigo is limited. The aim of the study was to compare the efficacy, safety and adherence to treatment of mupirocin with fusidic acid in primary impetigo.</p><p class="abstract"><strong>Methods:</strong> A total of 60 patients with a clinical diagnosis of primary impetigo, between 2-14 years of age, having &lt;10 lesions, skin infection rating score &gt;4 and pus score equal to or more than one who attended Dermatology OPD, in Chengalpattu Medical College Hospital from February 2018 to March 2019. Study design was a comparative analytical study.<strong></strong></p><p class="abstract"><strong>Results:</strong> Baseline disease characteristics such as number of lesions, the severity of disease (SIRS), and pus scores were statistically similar between the two groups. The clinical improvement observed with mupirocin (25/30) and fusidic acid (24/30) treatment in primary impetigo was not statistically significant (p&gt;0.05). Both drugs were tolerated well.</p><p><strong>Conclusions:</strong> Both mupirocin and fusidic acid showed similar clinical success in patients with primary impetigo. Though fusidic acid has additional anti-inflammatory property and its treatment is cost effective, but irritant effects observed in some patients, which reduces the compliance, lead to consider mupirocin as first line treatment in primary impetigo. </p>
HISTÓRIA, POLÍTICA E EDUCAÇÃO EM HANNAH ARENDT
Authors: Da Silva Mauro Sérgio Santos , Danelon Márcio 
Published: May 2019

O presente trabalho discorre acerca da relação entre as noções de história, política e educação a partir do pensamento de Hannah Arendt. Para tanto, traz à baila os elementos que, para a autora, circundam a ideia de história do paradigma grego antepostos à compreensão moderna de história. Apoiado nas reflexões de Flores D’arcais expõe a crítica da autora às filosofias da história erguidas sob a influência de uma concepção de história como processo causal com leis e normas que se sobrepõem aos acontecimentos, aos indivíduos, às iniciativas, à ação e, em última instância, à liberdade. Aponta as condições de possibilidade de uma ação política (livre) e, por conseguinte, da acepção de educação consentânea com tal ação.
Palavras-chave: Arendt, História, Política, Educação.
YAKIT TİPİNİN VE HİBRİT SEVK SİSTEMİNİN YAKIT TÜKETİMİNE ETKİSİ: İZMİR ALSANCAK LİMANINDA BİR HİZMET GEMİSİ İÇİN UYGULAMA
Authors: BAYRAKTAR Murat , BİLİR FİDAN Cennet Özlem , CERİT A. Güldem 
Published: May 2019

Denizcilik sektöründe sistemlerin işletilmesi sırasında kullanılan
araçların enerji tüketimini azaltma yolunda dünya çapında araştırma ve
geliştirme çalışmaları yapılmakta ve bu çalışmaları yaparken çevreci olma şartı
istenmektedir. Uluslararası Denizcilik Örgütü (IMO) ‘nün MARPOL Ek VI
"Gemilerden Kaynaklanan Hava Kirliliğinin Önlenmesine Yönelik
Düzenlemeler" göz önünde bulundurulduğunda deniz taşıtlarında enerji
kazanımı ve düşük salım değerleri elde etmek, daha fazla önem arz etmektedir.
Bu bağlamda deniz ulaştırma sistemlerinde enerji kazanımı sağlamak için gemi
ana makinesinde, gemi gövdesi ve sevk sisteminde teknolojik gelişmelere katkı
sağlayacak çalışmalar yapılmaktadır. IMO tarafından oluşturulan Enerji
Verimliliği Tasarım Endeksi yeni inşa edilen gemiler için en önemli
parametrelerden biri olup daha fazla enerji tasarrufu yapan ve daha az salım
yapan ekipman ve gemi makinelerin kullanımını teşvik etmeyi amaçlamaktadır.

Bu çalışmada liman işletim sisteminin önemli bir parçası olan, gemilerin
zamanında limana girip çıkmaları ve manevralarına doğrudan destek veren
römorkörlerin, römorkaj hizmeti esnasındaki yakıt tüketimi değerleri, toplam
operasyon süreleri, kullanılan yakıtların tipi ve bu yakıtların analiz
değerleri elde edilmektedir. Römorkaj hizmeti veren römorkörlerde var olan ana
makine sisteminde iyileştirmeler teorik olarak ele alınmış ve sistem üzerindeki
etkilerini gösterilmektedir. Operasyon sırasında sistemde kullanılan yakıtın yerine
alternatif yakıtların kullanılmasıyla sistemde oluşabilecek olumlu ve olumsuz
sonuçlar ifade edilmektedir.
MARİNALARDA ÇEVRE YÖNETİMİ UYGULAMALARI: TÜRKİYE MARİNALARI ÜZERİNE BİR ÇALIŞMA*
Authors: AKALTAN Can , GÖKDEMİR IŞIK Nurser 
Published: May 2019

Deniz turizmi, turizm sektörünün bileşenleri arasında
ülke ekonomilerine ve tanıtımlarına yaptığı katkılar ile önemli bir yere
sahiptir. Deniz turizmi çeşitleri arasında yatçılık ve marinacılık ülkemizde
öne çıkan başlıklar olmuşlardır. Günümüz marinaları güvenli limanlar olmanın
ötesinde birçok hizmet ve faaliyetin yer aldığı destinasyonlar haline
dönüşmüşlerdir. Hizmet ve faaliyetlerdeki artış, çevreye olan zararlı etkilerin
de artışına sebep olabilmektedir. Çevre yönetimi uygulamaları, marinaların ekonomik
ve çevresel sürdürülebilirliklerini korumaları için her geçen gün daha önemli
hale gelmektedir. Bu çalışmanın amacı, çevre yönetim uygulamalarındaki
eksiklikleri belirlemek ve Türk marinalarında çevre yönetim uygulamalarının
uygulanmasını etkileyen faktörleri tespit etmektir. Bu çalışma belirli
tecrübesi bulunan uzman Türk marina yöneticilerinin katılımlarıyla nitel
araştırma yöntemi olan yapılandırılmış mülakat tekniği kullanılarak
sonuçlandırılmıştır. Elde edilen veriler içerik analizi yapmak suretiyle
değerlendirilmiştir. Mevcut ve planlanan marina yatırımlarında doğaya verilecek
zararların en aza indirilmesi, gelecek nesillere bırakacağımız en büyük
mirasımız olan doğal kaynaklarımızın korunması için büyük önem arz etmektedir.
Çevre yönetim uygulamalarını dikkate almayan işletmelerin varlıkları, değişen
çevre anlayışı ile birlikte şüphesiz tehlikeye girecektir.
Valoración de una finca en periodo de transición a un sistema de producción orgánica en Cipreses de Oreamuno, en la provincia de Cartago, Costa Rica.
Authors: Montero Solís Nataly , González Blanco Carlos , Barboza Navarro David , Arroyo Acuña Rodrigo 
Published: May 2019

Se procedió a realizar el avalúo de una finca ubicada en Cipreses de Oreamuno, en la provincia de Cartago, Costa Rica, que actualmente se dedica al cultivo de hortalizas y se encuentra en periodo de transición para la producción orgánica. A futuro, se pretende ejecutar un proyecto de inversión en infraestructura, por lo que resulta indispensable conocer el valor actual de la finca y el valor con las mejoras respectivas.
Según la capacidad de uso de la tierra, el terreno se clasifica como IIIe1c1 con una pendiente de 9% y se ubica en una zona de Bosque muy Húmedo Premontano. Para realizar el avalúo del terreno se implementaron distintos métodos utilizados en la tasación, incluidos el econométrico, comparativo y financiero; y se realizó un promedio simple de los tres métodos anteriores que permitió estimar el precio/m2 en ₡6.182, para un valor total del terreno de ₡47.392.188 con un área de 7.675,75 m2.
También, por medio del método de costeo directo y las tipologías de construcción, respectivamente, se estimó el valor de un invernadero establecido en la finca que asciende a ₡9.272.890 y la construcción de tres infraestructuras (una cabaña, un granero y un estanque), que corresponden al proyecto de inversión, generando un aumento de ₡106.657.646 en el valor total de la propiedad, incluyendo mejoras en el servicio eléctrico y en la vía de acceso terrestre.
An Agent-Based Simulation Model of Knowledge Spillover Under the Influence of High-Speed Railway
Authors: Zhao Yun , Bi Chongren 
Published: May 2019

Abstract
The calculation for the influence of high-speed railway on knowledge spillover is based on the results of global instantaneous equilibrium in the mechanism explanation of knowledge spillover. In real production, the interaction between the high-speed railway and the regional innovation system is dynamic and local. In order to simulate the impact of high-speed railway on innovation activities in the time dimension, it is necessary to simulate scenarios under appropriate parameter assumptions. Based on the interaction of economic participants, a discrete evolutionary simulation model is established, which is helpful to predict and estimate the evolution of spatial effect of high-speed railway according to the theory of cellular automata. It is concluded that high-speed railway accelerates the formation of knowledge innovation industry cluster in the region in the process of regional knowledge innovation and evolution. Under the influence of high-speed railway, the node city will gradually evolve into a regional innovation center. By comparing the production evolution of knowledge innovation system with and without high-speed railway, the results show that high-speed railway has a more significant impact on knowledge spillover in higher knowledge privatization environment. Under the background of low labor migration rate, high-speed railway has increased the potential of regional innovation to external knowledge spillover. In the case of higher labor migration rate, the convergence rate of influence of high-speed railway on the concentration of innovation is faster.
Inventory Policy for a Deteriorating Item with Time-Varying Demand Under Trade Credit and Inflation
Authors: Wang Luqi , Chen Zhijian , Chen Mingyao , Zhang Ruijie 
Published: May 2019

Abstract
It’s often the case that the supplier will provide the retailer with a permissible delay period in payments, during which the supplier charges the retailer no interest and the retailer accumulates interest earned from investment return. As a type of price reduction and an alternative to price discount, trade credit helps the supplier encourage the retailer’s ordering. This paper develops an inventory replenishment model for a deteriorating item with time-varying demand and shortages, taking account of trade credit and time value of money under inflation over a finite time horizon. This model is an extension and development of the existing studies related to the inventory system considering trade credit and time value of money and offers a more general model with more flexibility and resilience to handle the situation where demand of the end market is non-decreasing with regard to time.
The Simulation Optimization of Miners’ Unsafe Behavior Control Method
Authors: Zhang Jiangshi , Hao Hongyu , Li Xue , Zhang Wenyue 
Published: May 2019

Abstract
Making optimal safety investment decisions are important for improving worker’s safety level and reducing accident frequency. To study the complex relationship between safety investment and miners’ behavior-based safety, we proposed the index system of the influential factors on miners’ unsafe behaviors and utilized system dynamics (SD) method to construct the analysis model. Based on the empirical research on a mining company in Hunan, miners’ behavior-based safety level under different investment conditions were simulated, then 12 kinds of schemes’ simulation were obtained. Finally, the optimal scheme was achieved. The scheme is: Safety cost per ton of coal is 3.8 dollars, investment proportion is: Organizational management (0.44), safety climate (0.16), working environment (0.08), technological equipment (0.32). This scheme reached the target value of 90 in the 28th month, which was 9 months shorter than that of the original one. The optimized results show that increasing the behavior-based safety investment and adjusting the proportion appropriately, can improve miners’ behavior-based safety level effectively.
A Modified CES Production Function Model and Its Application in Calculating the Contribution Rate of Energy and Other Influencing Factors to Economic Growth
Authors: Cheng Maolin , Shi Guojun , Han Yun 
Published: May 2019

Abstract
In the analysis of economic growth factors, the constant elasticity of substitution (CES) production function model is used to calculate the contribution rates of influencing factors to economic growth. However, the traditional CES production function model fails to consider the staged characteristics of economic growth. Therefore, this study provides a modified model of the CES production function. With regard to its application, a new method for calculating the contribution rates of energy and other influencing factors to economic growth is proposed using a modified CES production function model. This work concludes by calculating the contribution rates of Chinese energy and other influencing factors to economic growth.
Research on the Loss Sharing Contract in Supply Chain Under Asymmetric Information
Authors: Sun Jinling , Zhu Peiyu , Jin Shumo , Wang Hongbin 
Published: May 2019

Abstract
In this study, the coordination contract of internal and external losses of supply chain under asymmetric information is studied. Firstly, the profit functions of supplier and manufacturer are established respectively. Secondly, the contract under unilateral and bilateral moral hazard is designed. Finally, a numerical example is given to analyze the coordination contract. It is proved that the overall coordination of supply chain can be achieved through loss sharing contract, and the quality level and overall profit can be improved.
Gloriosa superba and Colchicum autumnale multi-tissue transcriptome analysis for colchicine pathway and rhizome development candidate gene identification
Authors: Bass John Samuel , Gang David R. , Kutchan Toni M. , Sivakumar Ganapathy 
Published: May 2019

Abstract
Background

The continued emergence of side-effects caused by synthetic drugs underscores the need for plant-based drugs in human medicine. Medicinal rhizomatous crops are a “goldmine for modern drugs”, and include such species as Gloriosa superba L. and Colchicum autumnale L., the producers of colchicine, a plant-based medicine. The natural isomer of bioactive colchicine is used to effectively treat major diseases such as cancer, cardiovascular disease, and gout. The medicinal properties of colchicine are well characterized, however, almost nothing is known about its biosynthesis. The paucity of information on the colchicine biosynthetic pathway is a significant barrier to biomanufacturing of this biomedicine. A comparative transcriptome study of G. superba and C. autumnale serves as a sequence resource to aid with identification of this biomedicine pathway and rhizome development genes for synthetic biotechnology toolbox, which will enable improved colchicine biomanufacturing.

Result

Transcriptomes of two colchicine synthesizing monocots G. superba and C. autumnale were interrogated to identify putative cDNAs encoding enzymes and transcription factors involved in the colchicine biosynthetic pathway and rhizome development. Mining of the transcriptomes using Blast2GO led to the identification from G. superba and C. autumnale, respectively, of 20 and 29 candidate colchicine biosynthetic genes N-methyltransferases, 3-O-methyltransferases, cytochrome P450s, a class that could catalyze several steps in the pathway, and N-acetyltransferases. Similarly, 19 and 15 candidate rhizome developmental genes, which belongs to several classes including GIGANTEA, CONSTANS, Phytochrome B, Sucrose Synthase), Flowering Locus T, and REVOLUTA. Likewise, about 16 and 12 transcription factors involved in regulating rhizome development and secondary metabolic pathways in rhizomes such as MADS-box, AP2-EREBP, bHLH, MYB, NAC, and WRKY were also found in G. superba and C. autumnale, respectively.

Conclusion

The predicted genes in G. superba and C. autumnale encode colchicine pathway enzymes that provide fundamental information for plant-based biomedicine engineering in biorhizomes and microorganisms, a potentially important area of synthetic biotechnology. Additionally, increasing our understanding of rhizome functional genomics will lead to improved colchicine biomanufacturing, and generate important knowledge that can be applied to many other medicinal plant species, allowing for the engineered production of additional biomedicines in medicinal rhizomes.
Women’s experience of unplanned out-of-hospital birth in paramedic care
Authors: Flanagan Belinda , Lord Bill , Reed Rachel , Crimmins Gail 
Published: May 2019

Abstract
Background
Healthcare literature describes predisposing factors, clinical risk, maternal and neonatal clinical outcomes of unplanned out-of-hospital birth; however, there is little quality research available that explores the experiences of mothers who birth prior to arrival at hospital.
Methods
This study utilised a narrative inquiry methodology to explore the experiences of women who birth in paramedic care.
Results
The inquiry was underscored by twenty-two narrative interviews of women who birthed in paramedic care in Queensland, Australia between 2011-2016. This data identified factors that contributed to the planned hospital birth occurring in the out-of-hospital setting. Women in this study began their story by discussing previous birth experience and their knowledge, expectations and personal beliefs concerning the birth process. Specific to the actual birth event, women reported feeling empowered, confident and exhilarated. However, some participants also identified concerns with paramedics practice; lack of privacy, poor interpersonal skills, and a lack of consent for certain procedures.
Conclusions
This study identified several factors and a subset of factors that contributed to their experiences of the planned hospital birth occurring in the out-of-hospital setting. Women described opportunities for improvement in the care provided by paramedics, specifically some deficiencies in technical and interpersonal skills.
The organization of Helicobacter pylori cag-pathogenicity island (cagPAI) genes in multiracial population with histopathological changes of gastric mucosa
Authors: Hanafiah Alfizah , Razak Shaza Azlin , Neoh Hui-min , Zin Noraziah Mohamad , Lopes Bruno S. 
Published: May 2019

Abstract
Background: Helicobacter pylori is a Gram-negative bacillus that colonises only the mucus layer of the human stomach and is implicated in gastric diseases. Virulent H. pylori harbouring cag-pathogenicity island (cagPAI) which encodes genes for type IV secretion system (T4SS) and CagA protein is one of the major virulence determinants involved in disease development. We examined the entire cagPAI genes in 95 H. pylori isolates from a multiracial population and examined the intactness of cagPAI region with histopathological scores of the gastric mucosa.
Results: 95.8% of H. pylori isolates were cagPAI-positive with 23.2% having an intact cagPAI, whereas 72.6% had a partial/rearranged cagPAI. In our study, cag2 and cag4 were found to be significantly higher in H. pylori isolated from Malays, whereas cag4 was predominant in Chinese isolates. We also detected cag24 in significantly high proportion in isolates from the Malays and the Indians compared to the Chinese isolates. The intactness of cagPAI region showed an association with histopathological scores of the gastric mucosa. Significant association was observed between H. pylori harbouring partial cagPAI and higher density of H. pylori and neutrophil activity, whereas strains which lacked cagPAI was associated with higher inflammatory score.
Conclusions: The screening of the entire cagPAI genes provides an accurate overview of the cagPAI organisation in H. pylori isolates in a multiracial population. The genotypes of H. pylori strains with various cagPAI rearrangement associated with patients’ ethnicities and histopathological scores might contribute to the pathogenesis of H. pylori infection in a multi-ethnic population.
Comparative transcriptome analysis reveals storage carbohydrates related genes in kelp Saccharina japonica
Authors: Zhang Linan , Cao Zengmei , Liang Guangjin , Li Xiaojie , Wu Hao 
Published: May 2019

Abstract
Background

Saccharina japonica is a brown macroalga commercially cultivated in China for almost a century. As a natural raw material, it has been widely used to extract carbohydrates, e.g. alginate and mannitol, for food, pharmaceutical, and potentially for biofuel production. However, the molecular mechanisms of biosynthesis and regulation of these compounds in this species are not comprehensive and less well understood.

Results

In this study, we performed whole transcriptome and differential transcript expression analyses of S. japonica sporophyte of distinct developmental stages. Combined with the phenotype of blade and the content of alginate and mannitol, the sporophyte could be divided into four developmental stages. Accordingly, 589 million clean reads were generated, and 98,497 novel transcripts and 4,514 novel genes were identified by transcriptome analysis. Gene expression analysis revealed that 2,542 genes were differentially expressed. KEGG analysis indicated that these genes were significantly enriched in “Carbon metabolism”, “Photosynthesis”, and “Photosynthesis-antenna proteins” pathways, which were important for carbohydrates metabolism during sporophyte development. Through a systematic analysis, the genes encoding enzymes for biosynthesis of cell wall carbohydrates (including alginate, fucoidan and cellulose) and cytoplasm storage carbohydrates (mannitol, laminarin and trehalose) were identified, representing good candidates for further functional studies.

Conclusion

The work presented is the first transcriptome analysis of sporophytes development and provides a dynamic view of carbohydrate metabolism process and an important resource for functional genomics studies in S. japonica. The results obtained lay the basis for elucidating the molecular mechanism of carbohydrate biosynthesis and for genetic breeding of carbohydrates-related traits in kelp.