bluuebunny/crossref_metadata_2025_split huggingface dataset:
Correlations of non-affine displacements in metallic glasses through the yield transition
Authors: Jana Richard , Pastewka Lars 
Published: July 2019

Abstract
We study correlations of non-affine displacements during simple shear deformation of Cu–Zr bulk metallic glasses in molecular dynamics calculations. In the elastic regime, our calculations show exponential correlation with a decay length that we interpret as the size of a shear transformation zone in the elastic regime. This correlation length becomes system-size dependent beyond the yield transition as our calculation develops a shear band, indicative of a diverging length scale. We discuss these observations in the context of a recent proposition of yield as a first-order phase transition.
Back and front contacts in kesterite solar cells: state-of-the-art and open questions
Authors: Platzer-Björkman Charlotte , Barreau Nicolas , Bär Marcus , Choubrac Leo , Grenet Louis , Heo Jaeyeong , Kubart Tomas , Mittiga Alberto , Sanchez Yudania , Scragg Jonathan , Sinha Soumyadeep , Valentini Matteo 
Published: July 2019

Abstract
We review the present state-of-the-art within back and front contacts in kesterite thin film solar cells, as well as the current challenges. At the back contact, molybdenum (Mo) is generally used, and thick Mo(S, Se)2 films of up to several hundred nanometers are seen in record devices, in particular for selenium-rich kesterite. The electrical properties of Mo(S, Se)2 can vary strongly depending on orientation and indiffusion of elements from the device stack, and there are indications that the back contact properties are less ideal in the sulfide as compared to the selenide case. However, the electronic interface structure of this contact is generally not well-studied and thus poorly understood, and more measurements are needed for a conclusive statement. Transparent back contacts is a relatively new topic attracting attention as crucial component in bifacial and multijunction solar cells. Front illuminated efficiencies of up to 6% have so far been achieved by adding interlayers that are not always fully transparent. For the front contact, a favorable energy level alignment at the kesterite/CdS interface can be confirmed for kesterite absorbers with an intermediate [S]/([S]+[Se]) composition. This agrees with the fact that kesterite absorbers of this composition reach highest efficiencies when CdS buffer layers are employed, while alternative buffer materials with larger band gap, such as Cd1−x
Zn
x
S or Zn1−x
Sn
x
O
y
, result in higher efficiencies than devices with CdS buffers when sulfur-rich kesterite absorbers are used. Etching of the kesterite absorber surface, and annealing in air or inert atmosphere before or after buffer layer deposition, has shown strong impact on device performance. Heterojunction annealing to promote interdiffusion was used for the highest performing sulfide kesterite device and air-annealing was reported important for selenium-rich record solar cells.
Social Media Marketing: What Do Prospective Patients Want to See?
Authors: Klietz Marie-Luise , Kaiser Hans Wilhelm , Machens Hans-Günther , Aitzetmüller Matthias Michael 
Published: July 2019

Abstract

Background
Platforms such as Instagram, Facebook, Twitter, and Google+ have created a worldwide audience of almost 3 billion people. Society is dramatically changing, demanding evolution of marketing strategies by plastic surgeons and aesthetic doctors alike. This unknown territory provides excellent opportunities, but creates many pitfalls as well; uncertainty remains as to the most effective manner to promote one’s practice/services.

Objectives
The aim of this study was to design a social experiment based on Instagram to give guidance for efficient self-promotion.

Methods
An Instagram account called “doctor.aesthetics” was created. Content was produced, and categorized into 4 groups: Aesthetics, Private Life, Disease, and Science. No bots or other Instagram-based promotion were utilized. Every post was evaluated regarding likes, comments, clicks, new followers, impressions, and savings.

Results
After 5 months and 37 posts, 10,500 people followed the account. “Scientific” posts were excluded from the analysis due to a low response rate. A significantly enhanced number of likes for “Private” postings was found. Additionally, “Private” posts led to most clicks and new followers, whereas “Aesthetics” posts were saved by most people.

Conclusions
To benefit the most from social media advertising, it is necessary to offer insights into private life. Although “Aesthetics” and “Disease” postings showed similar response rates, “Scientific” posts failed to attract people.
Landmarks in Facial Rejuvenation Surgery: The Top 50 Most Cited Articles
Authors: Kreutz-Rodrigues Lucas , Shapiro Daniel , Mardini Samir , Bakri Karim 
Published: July 2019

Abstract

Background
Facial rejuvenation procedures are common in plastic surgery.

Objectives
The aim of this study was to report the 50 most cited articles in the field of aesthetic facial rejuvenation surgery and provide a simple educational resource for plastic surgeons.

Methods
The authors utilized the Web of Science Citation Index to identify the 50 most cited articles related to surgery for facial rejuvenation published from 1950 to 2019. Articles were classified according to their level of evidence, type of study, country of publication, and topic of interest: facelift, blepharoplasty, brow lift, neck lift, or combined areas.

Results
The mean number of citations per article was 137, and the majority of articles (n = 19) were published between 1990 and 1999. The most prevalent topic was facelift surgery (n = 24), followed by articles discussing combined procedures (n = 13), blepharoplasty (n = 6), brow lift (n = 4), and neck lift (n = 3). Most of the articles were classified as clinical (n = 26), followed by basic science studies (n = 12) and review articles (n = 12). Among the articles amenable to grading level of evidence (n = 26), most (n = 24) presented their findings utilizing level IV evidence. The nation of origin for most of the articles (n = 41) was the United States.

Conclusions
Articles addressing facelift surgery represented the largest proportion of peer-reviewed landmark publications in aesthetic facial surgery research. A simple educational resource is presented to encourage the appreciation of the research in this field.
Phenotypic selection by kelp gulls against pear-shaped shells of the Antarctic limpet Nacella concinna
Authors: Castillo Santiago , de Aranzamendi María Carla , Martínez Juan José , Sahade Ricardo 
Published: July 2019

AbstractThe Antarctic limpet (Nacella concinna) presents two ecotypes related to different water depths: littoral individuals have a robust and taller shell while sublittoral individuals are thinner and flatter. Among the environmental factors possibly causing this divergence, avian predation upon littoral individuals has been mooted but has received little research attention. The kelp gull (Larus dominicanus) is the principal consumer of littoral limpets in the study area. We used shells from littoral and sublittoral zones, and from gull middens to examine – through linear morphometrics and elliptic Fourier analysis – whether selective predation exists, and to evaluate the mode of selection that could be operating on different traits. We found that limpet individuals with the apex displaced towards the anterior side were more likely to be predated. However, a remarkable result was that gulls select dorsal pear-shaped rather than elliptical shells and that there is a directional selection against pear-shaped limpets. However, in contrast to previous studies, we did not find that the proportions of elliptical or pear-shaped individuals differed between the littoral and sublittoral zones. This discrepancy could be related to variations in predatory intensity in different locations. These results suggest that where gulls have a strong influence, their effect could be a key factor in dorsal differentiation in limpet shells.
New insights into population structure of the European golden eagle (Aquila chrysaetos) revealed by microsatellite analysis
Authors: Nebel Carina , Gamauf Anita , Haring Elisabeth , Segelbacher Gernot , Väli Ülo , Villers Alexandre , Zachos Frank E 
Published: July 2019

AbstractConnectivity between golden eagle (Aquila chrysaetos) populations is poorly understood. Field studies exploring natal dispersal suggest that this raptor is a philopatric species, but with the ability to roam far. However, little is known about the population structure of the species in Europe. Our study is based on 14 microsatellite loci and is complemented by new and previously published mitochondrial control region DNA data. The present dataset includes 121 eagles from Scotland, Norway, Finland, Estonia, the Mediterranean and Alpine regions. Our sampling focused on the Alpine and Mediterranean populations because both mitochondrial DNA (mtDNA) lineages found in golden eagles, the Holarctic and the Mediterranean, are known to co-occur there. Cluster analyses of nuclear DNA support a shallow split into northern and southern populations in Europe, similar to the distribution of the two mtDNA lineages, with the Holarctic lineage occurring in the north and the Mediterranean lineage predominating in the south. Additionally, Scotland shows significant differentiation and low relative migration levels that indicate isolation from the mainland populations. Alpine and Mediterranean golden eagles do not show nuclear structure corresponding to divergent mtDNA lineages. This indicates that the presence of northern Holarctic mitochondrial haplotypes in the Alps and the Mediterranean is attributable to past admixture rather than recent long-distance dispersal.
MicroRNA-181a promotes follicular granulosa cell apoptosis via sphingosine-1-phosphate receptor 1 expression downregulation†
Authors: Zhang Chunxue , Shen Jingtao , Kong Shuangbo , Zhang Mei , Zhang Qun , Zhou Jidong , Zhen Xin , Kang Nannan , Jiang Yue , Ding Lijun , Sun Haixiang , Yan Guijun 
Published: July 2019

Abstract
Oxidative stress induces granulosa cell (GC) apoptosis and subsequent follicular atresia. Since our previous studies indicate that microRNA-181a (miR-181a) expression is increased in GCs undergoing apoptosis, the present study was designed to define the relationship between exposure to oxidative stressors in GCs and changes in miR-181a expression and function. To achieve this, we employed an H2O2-induced in vitro model and a 3-nitropropionic acid-induced in vivo model of ovarian oxidative stress. We demonstrated that in vitro miR-181a overexpression promoted GC apoptosis in a dose-dependent manner; sphingosine-1-phosphate (S1P) significantly reversed both H2O2-induced and miR-181a-induced apoptosis in GCs. Moreover, we identified sphingosine-1-phosphate receptor 1 (S1PR1), a critical receptor of S1P, as a novel target of miR-181a in GCs. MicroRNA-181a induced GC apoptosis by repressing S1PR1 expression in vitro. Importantly, increased miR-181a expression and decreased S1PR1 expression were detected in the in vivo ovarian oxidative stress model by Western blot analysis and immunohistochemistry. Furthermore, we found similar expression patterns of miR-181a and S1PR1 in GCs from patients with premature ovarian insufficiency. In conclusion, our results suggest that miR-181a directly suppresses expression of S1PR1, which has critical roles in mediating oxidative stress-induced GC apoptosis both in vitro and in vivo.
Versatility of reproductive modes and ploidy level interactions in Sorbus s.l. (Malinae, Rosaceae)
Authors: Lepší Martin , Koutecký Petr , Nosková Jana , Lepší Petr , Urfus Tomáš , Rich Tim C G 
Published: July 2019

Abstract
This study focuses on the frequency of reproductive modes and the role of reproductive mode variation in diversification of the genus Sorbus s.l. and evolutionary success of individual taxa. Our sampling covers all four ploidies known in Sorbus and includes stabilized taxa and recently formed biotypes. We infer reproductive modes of 3660 seeds using the flow cytometric seed screen method; we also calculated ploidy of contributing pollen. Sorbus shows high variability in reproduction pathways (sexuality, apomixis, formation of BIII hybrids, haploid parthenogenesis). Diploids are sexual, whereas polyploids show predominantly pseudogamous apomixis. In half of the polyploids studied, several reproductive modes were present and even intra-individual variation was detected. Diploids, tetraploids and pentaploids are pollinated by conspecific pollen, whereas triploids are largely, but not fully, dependent on the pollen of other species. In pseudogamous seeds, fertilization of the central cell by both sperms is a dominant pathway of endosperm origin. Flow cytometry of pollen did not detect unreduced pollen at any ploidy. The principal mechanisms of diversification in Sorbus are residual sexuality in apomicts, production of triploid taxa from diploid–tetraploid crosses and production of BIII hybrids. Evolutionary success of Sorbus taxa is largely dependent on the breeding system and is determined by self-(in)compatibility and the interplay between stabilizing apomixis and variation-generating sexuality.
Targeting β-tubulin/CCT-β complex induces apoptosis and suppresses migration and invasion of highly metastatic lung adenocarcinoma
Authors: Liu Yan-Jin , Chang Yu-Ju , Kuo Yu-Ting , Liang Po-Huang 
Published: July 2019

Abstract
Metastasis, the movement of cancer cells from one site to another, is responsible for the highest number of cancer deaths, especially in lung cancer patients. In this study, we first identified a prognostic marker of lung adenocarcinoma, TCP-1 β subunit (chaperonin-containing TCP-1β; CCT-β). We showed a compound that disrupted the interaction of CCT-β with β-tubulin killed a highly metastatic non-small cell lung cancer cell line CL1-5 through inducing Endoplasmic reticulum stress and caspases activation. Moreover, at the dosage of EC20, the compound inhibited migration and invasion of the lung cancer cells by suppressing matrix metalloproteinase (MMP)-2/9 and epithelial–mesenchymal transition (EMT)-related proteins through downregulating mitogen-activated protein kinases (MAPKs), Akt/β-catenin and integrin–focal adhesion kinase signaling pathways. Unlike the anticancer drugs, such as Taxol, that target the adenosine triphosphate site of β-tubulin, this study reveals a therapeutic target, β-tubulin/CCT-β complex, for metastatic human lung adenocarcinoma.
The study demonstrated CCT-β as a prognostic marker. Targeting β-tubulin/CCT-β complex caused apoptosis and inhibited invasion/migration of CCT-β overexpressed, highly metastatic lung adenocarcinoma.
Periodontitis is associated with hypertension: a systematic review and meta-analysis
Authors: Muñoz Aguilera Eva , Suvan Jean , Buti Jacopo , Czesnikiewicz-Guzik Marta , Barbosa Ribeiro Aline , Orlandi Marco , Guzik Tomasz J , Hingorani Aroon D , Nart Jose , D’Aiuto Francesco 
Published: July 2019

AbstractRecent evidence suggests a link between periodontitis (PD) and hypertension, but the nature of this association remains unclear. The overall aim of this review was to critically appraise the evidence linking these two common disorders. Systematic search was conducted for studies published up to December 2018. Prevalence of hypertension in patients with PD (moderate/severe groups) vs. those without PD (non-PD) was the primary outcome. Additional outcomes included adjusted mean difference in systolic (SBP) and diastolic (DBP) blood pressure (BP) levels in PD vs. non-PD, assessment of biomarkers in PD and hypertension, and BP changes after periodontal therapy. From 81 studies selected, 40 were included in quantitative meta-analyses. Diagnoses of moderate-severe PD [odds ratio (OR) = 1.22; 95% confidence interval (CI): 1.10–1.35] and severe PD (OR = 1.49; 95% CI: 1.09–2.05) were associated with hypertension. Prospective studies confirmed PD diagnosis increased likelihood of hypertension occurrence (OR = 1.68; 95% CI: 0.85–3.35). Patients with PD exhibited higher mean SBP [weighted mean difference (WMD) of 4.49 mmHg; 95% CI: 2.88–6.11] and DBP (2.03 mmHg; 95% CI: 1.25–2.81) when compared with non-PD. Lastly, only 5 out of 12 interventional studies confirmed a reduction in BP following periodontal therapy, ranging from 3 to 12.5 mmHg of SBP and from 0 to 10 mmHg of DBP. PD is associated with increased odds of hypertension (SORT C) and higher SBP/DBP levels. The evidence suggesting that PD therapy could reduce BP is inconclusive. Although additional research is warranted on this association, these results suggest that oral health assessment and management of PD could not only improve oral/overall health and quality of life but also be of relevance in the management of patients with hypertension.
The conundrum of endovascular common femoral artery treatment: a case report of lithoplasty as a viable solution
Authors: Trani Carlo , Russo Giulio , Aurigemma Cristina , Burzotta Francesco 
Published: July 2019

AbstractBackgroundHighly calcific stenosis located in common femoral artery (CFA) represents a difficult target for endovascular treatment due to the possible need for stent implantation in that area.Case summaryA 63-year-old man with history of coronary artery disease and previous multiple percutaneous transluminal angioplasties for peripheral artery disease (PAD) was admitted for recent onset left lower limb pain at rest with severe activity restriction (Leriche-Fontaine Class III and Rutherford Class III–IV). The angio-computed tomography scan showed a highly calcific stenosis of left CFA. The patient underwent lithoplasty balloon angioplasty followed by drug-eluting balloon inflation with excellent angiographic result and complete blood flow restoration. No procedural complications occurred.DiscussionHighly calcified stenosis in PAD represents a huge challenge for endovascular treatment as not all lower extremity arteries are suitable for stenting because of compressive and torsional forces associated with stent fracture and restenosis. Lithoplasty is a new technology allowing effective blood flow restoration while minimizing vessel injury.
Growth and survival dynamics of partially cut northern hardwood stands as affected by precut competition and spatial distribution of residual trees
Authors: Moreau Guillaume , Achim Alexis , Pothier David 
Published: July 2019

Abstract
Modelling growth and survival dynamics after partial harvesting must take account of the heterogeneous spatial pattern of residual trees that results from the presence of machinery trails. We used data from 23 permanent sample plots in northern hardwood stands to reconstruct the growing environment of individual trees before and after partial harvesting. We modelled harvest probability, growth response and survival probability using a complementary set of explanatory variables that was assembled to reflect the spatial distribution of trees and skid trails prior to and after harvest. Results showed that the distribution of harvested trees was concentrated in skid trails and in their close vicinity. However, this spatial pattern had no significant effect on either the post-cut basal area increment (BAI) or the survival of residual trees. BAI and survival of individual trees were both mostly related to the competitive environment prior to harvest, while post-cut changes in competitive environment had only a marginal effect on growth and survival dynamics. We conclude that selection cuts did not substantially increase the growth and survival of residual trees, likely because tree removal was mostly concentrated near skid trails, where the negative effects of machinery access were highest.
Early Modern Oels and the Singularities of Local History*
Authors: Piasecka Maria 
Published: July 2019

Abstract
The article explores the local history of the Silesian city of Oels as presented in selected early modern books and pamphlets published primarily in the local print shop, but also in other cities. A prominent example of such a historical event is the 1535 tempest, descriptions of which were published in its immediate aftermath. The much-later Beschreibung of 1657 is presented as an example of creating local identity through emphasizing two cultural aspects linked to the event: the alleged nefarious role of the Jewish community and the special relationship of the local citizens with the dukes of, at first, the Podebrad, and later the Württemberg families. Although natural disasters are repetitive occurrences, the 1535 tempest was understood by the people of Oels in a singular manner, which was characteristic for the local context. The thesis about the singularity of the local history is further corroborated through a number of examples from Oels. Different aspects of singularity dominate in different publications depicting local events: the singularity of situations, people and places.
Evidence of a Link Between Fall-Related Anxiety and High-Risk Patterns of Visual Search in Older Adults During Adaptive Locomotion
Authors: Ellmers Toby J , Cocks Adam J , Young William R 
Published: July 2019

Abstract

Background
Older adults deemed to be at a high risk of falling will often display visual search behaviors likely to impair movement planning when negotiating environmental hazards. It has been proposed that these behaviors may be underpinned by fall-related anxiety. Thus, the aim of this study was to explore the effects of fall-related anxiety on visual search and stepping behaviors during adaptive gait.

Methods
Forty-four community-dwelling older adults (mean age = 74.61; standard deviation = 6.83) walked along a path and stepped into two raised targets. All participants completed walks at ground level, whereas participants deemed to be at a low risk of falling (n = 24) also completed walks under conditions designed to induce fall-related anxiety (walkway elevated 0.6 m). Participants’ movement kinematics and gaze behavior were measured.

Results
During ground trials, “high-risk” participants visually prioritized the immediate walkway areas 1–2 steps ahead, at the expense of previewing future stepping constraints. This reduced planning appeared to negatively affect safety, with greater stepping errors observed for future constraints. When completing walks on the elevated walkway, “low-risk” participants similarly prioritized immediate walkway areas, at the expense of planning future stepping actions. These behaviors were associated with greater attention directed toward consciously processing walking movements.

Conclusions
These findings provide evidence of a link between heightened fall-related anxiety and “high-risk” visual search behaviors associated with greater stepping errors. This information enhances our understanding of why high-risk older adults are less able to safely navigate environmental constraints.