bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tratamento conservador em fratura da extremidade distal do rádio: relato de caso
Authors: Almeida João Gabriel Machado de , Sily Isabella Fioresi , Ribeiro Nicolly Tomaz , Araújo Victória Gama de , Simonassi Vitor Pertel , Motta Rodrigo Cezar Gonçalves , Pedruzzi Lucas 
Published: December 2024

A fratura da extremidade distal do rádio é a mais comum no membro superior. Dados dos Estados Unidos apontam uma incidência de 643.000 por ano. Apresenta distribuição bimodal, com primeiro pico entre os 5 e os 24 anos de idade e o segundo em idosos, principalmente mulheres. Este trabalho pretende contribuir com o entendimento a respeito do tratamento desta fratura de forma conservadora, demonstrando como conduzi-la, seu método e critérios. O caso abordado trata-se de uma paciente do sexo feminino de 65 anos, atendida no pronto socorro de um hospital em Vitória-ES, após queda da própria altura com trauma em punho direito. Realizada radiografia evidenciando fratura da extremidade distal do rádio direito extra-articular com desvio mínimo. Optado em comum acordo entre o ortopedista e a paciente tratamento de forma conservadora com redução incruenta, seguido de imobilização com gesso axilopalmar e seguimento ambulatorial. Substituída por gesso antebraquiopalmar após período. A escolha pelo método conservador foi feita pela sua classificação como Tipo 1 de Frykman, idade da paciente e características presentes e ausentes na lesão. Os benefícios da escolha do tratamento conservador são variados: menor invasão, risco reduzido de infecção, menor custo, mobilização mais rápida. Após período de tratamento conservador foi realizada uma nova radiografia que evidenciou fratura consolidada e sem sinais de sequelas. No caso citado, ao escolher pelo tratamento conservador apresentaram-se diversos benefícios e comprovou que para a paciente referida foi a melhor escolha.
A Novel Cell-Penetrating Peptide–Vascular Endothelial Growth Factor Small Interfering Ribonucleic Acid Complex That Mediates the Inhibition of Angiogenesis by Human Umbilical Vein Endothelial Cells and in an Ex Vivo Mouse Aorta Ring Model
Authors: Kim Minseo , Park Sangkyu , Kim Soyi , Seo Jeongmin , Roh Sangho 
Published: December 2024

Angiogenesis is mediated by vascular endothelial growth factor (VEGF), a protein that plays a key role in wound healing, inflammatory diseases, cardiovascular processes, ocular diseases, and tumor growth. Indeed, modulation of angiogenesis represents a potential approach to treating cancer and, as such, therapeutic approaches targeting VEGF and its receptors have been widely investigated as part of the broader search for curative interventions. Equally, RNA interference is a powerful tool for treating diseases, but its application as a disease treatment has been limited in part because of a lack of efficient small interfering RNA (siRNA) delivery systems. The purpose of this study was to characterize an amphipathic cell-penetrating peptide, Ara27, and its potential as an effective delivery vehicle as a conjugate with VEGF siRNA (siVEGF). In our study, we demonstrate that exposure of human umbilical vein endothelial cells (HUVECs) with Ara27–siVEGF complexes did not lead to cytotoxicity and can lead to down-regulation of cellular levels of both VEGF mRNA and protein. Moreover, treatment with the Ara27–siVEGF complex attenuates the phosphorylation of VEGFR2, Akt, and ERK in HUVECs and inhibits their capacity for wound healing and tube formation, both of which characteristics reflective of angiogenesis. In addition, we performed an ex vivo study to find that treatment with the Ara27–siVEGF complex inhibits aorta ring sprouting. Furthermore, the complex did not induce immunotoxicity in THP-1 and RAW264.7 cells. Taken together, our studies demonstrate that an Ara27–siVEGF conjugate is efficient for knockdown of VEGF in HUVECs to inhibit angiogenesis, without marked cytotoxic and immunotoxic effects.
Projected Humidification Expands the Sustainable Grazing Areas in the Drylands of the Qinghai–Xizang Plateau
Authors: Lu Tong , Li Changjia , Wang Shuai , Zhou Wenxin , Li Yazhe , Mao Zhenhua , Tang Qiang , Liu Jianbo , Xu Jiren 
Published: December 2024

The drylands on the Qinghai–Xizang Plateau are extremely sensitive to climate change and grazing activities. However, there is a lack of quantitative study of the combined effects of aridity and grazing pressure, which are vital in determining the sustainable grazing areas. In this study, a 2-dimensional threshold model was employed to assess the maximum allowable grazing pressure and determine the sustainable grazing areas under both historical conditions and projected climate change scenarios up to 2100. Results showed that 62.2% of the drylands under historical condition were unsuitable for grazing and 6.7% exceeded the ecological threshold, while 31.1% fell within the areas with sustainable grazing. Model projections indicate a trend toward humidification across the drylands under the climate change scenarios of RCP 4.5 and RCP 8.5. This process is expected to partially alleviate the negative impact of grazing, leading to an expansion of sustainable grazing areas to approximately 41.0% by 2100. These findings provide valuable insights for optimizing grazing strategies in the drylands of the Qinghai–Xizang Plateau in the future.
The drylands on the Qinghai–Xizang Plateau are extremely sensitive to climate change and grazing activities. However, there is a lack of quantitative study of the combined effects of aridity and grazing pressure, which are vital in determining the sustainable grazing areas. In this study, a 2-dimensional threshold model was employed to assess the maximum allowable grazing pressure and determine the sustainable grazing areas under both historical conditions and projected climate change scenarios up to 2100. Results showed that 62.2% of the drylands under historical condition were unsuitable for grazing and 6.7% exceeded the ecological threshold, while 31.1% fell within the areas with sustainable grazing. Model projections indicate a trend toward humidification across the drylands under the climate change scenarios of RCP 4.5 and RCP 8.5. This process is expected to partially alleviate the negative impact of grazing, leading to an expansion of sustainable grazing areas to approximately 41.0% by 2100. These findings provide valuable insights for optimizing grazing strategies in the drylands of the Qinghai–Xizang Plateau in the future.
Single-Nucleus RNA Sequencing Reveals the Spatiotemporal Dynamics of Disease-Associated Microglia in Amyotrophic Lateral Sclerosis
Authors: Chen Lu-Xi , Zhang Mei-Di , Xu Hai-Feng , Ye Hai-Qin , Chen Dian-Fu , Wang Pei-Shan , Bao Zhi-Wei , Zou Sheng-Mei , Lv Yong-Ting , Wu Zhi-Ying , Li Hong-Fu 
Published: December 2024

Disease-associated microglia (DAM) are observed in neurodegenerative diseases, demyelinating disorders, and aging. However, the spatiotemporal dynamics and evolutionary trajectory of DAM during the progression of amyotrophic lateral sclerosis (ALS) remain unclear. Using a mouse model of ALS that expresses a human
SOD1
gene mutation, we found that the microglia subtype DAM begins to appear following motor neuron degeneration, primarily in the brain stem and spinal cord. Using reverse transcription quantitative polymerase chain reaction, RNAscope in situ hybridization, and flow cytometry, we found that DAM increased in number as the disease progressed, reaching their peak in the late disease stage. DAM responded to disease progression in both SOD1
G93A
mice and sporadic ALS and
C9orf72
-mutated patients. Motor neuron loss in SOD1
G93A
mice exhibited 2 accelerated phases: P90 to P110 (early stage) and P130 to P150 (late stage). Some markers were synchronized with the accelerated phase of motor neuron loss, suggesting that these proteins may be particularly responsive to disease progression. Through pseudotime trajectory analysis, we tracked the dynamic transition of homeostatic microglia into DAM and cluster 6 microglia. Interestingly, we used the colony-stimulating factor 1 receptor (CSF1R) inhibitor PLX5622 to deplete microglia in SOD1
G93A
mice and observed that DAM survival is independent of CSF1R. An in vitro phagocytosis assay directly confirmed that DAM could phagocytose more beads than other microglia subtypes. These findings reveal that the induction of the DAM phenotype is a shared cross-species and cross-subtype characteristic in ALS. Inducing the DAM phenotype and enhancing its function during the early phase of disease progression, or the time window between P130 and P150 where motor neuron loss slows, could serve as a neuroprotective strategy for ALS.
Profil Penggunaan Antibiotik dengan Metode Defined Daily Dose pada Pasien Pneumonia Rawat Inap Salah Satu Rumah Sakit Swasta Tipe C di Minahasa
Authors: Clara Santi , Nangoy Edward , Posangi Jimmy 
Published: December 2024

Abstract: The high prevalence of pneumonia cases in Indonesia affects the increasing use of antibiotics, which can lead to resistance. The defined daily dose (DDD) method can be utilized to improve the quality of antibiotic use by enabling quantitative evaluation. This study aimed to determine the quantity of antibiotic use in pneumonia inpatients at type C private hospital in Minahasa from July 2022 to June 2023. This was a descriptive and retrospective study using secondary data of medical records of pneumonia inpatients that were calculated using the DDD method. The results obtained 45 pneumonia patients received antibiotic therapy. The highest usage antibiotic was ceftriaxone with 46.09 DDD/100 bed days. In conclusion, the administration of antibiotics for treatment was appropriate, however, there is a need to develop clinical pathway to provide a structured guidelines for patient management.
Keywords: antibiotics; pneumonia; defined daily dose

Abstrak: Tingginya kasus pneumonia di Indonesia memengaruhi peningkatan penggunaan antibiotik yang dapat menyebabkan kejadian resistensi. Metode defined daily dose (DDD) dapat digunakan untuk meningkatkan kualitas penggunaan antibiotik yakni dengan melakukan evaluasi secara kuantitatif. Penelitian ini bertujuan untuk mengetahui kuantitas penggunaan antibiotik pada pasien pneumonia rawat inap salah satu rumah sakit swasta Tipe C di Minahasa periode Juli 2022 - Juni 2023. Jenis penelitian ialah deskriptif dengan pendekatan retrospektif menggunakan data sekunder berupa rekam medis pasien yang selanjutnya dihitung dengan menggunakan metode DDD. Hasil penelitian mendapatkan 45 pasien pneumonia yang menerima terapi antibiotik. Antibiotik dengan jumlah penggunaan tertinggi yakni ceftriaxone dengan nilai sebesar 46,09 DDD/100 bed days. Simpulan penelitian ini ialah secara keseluruhan pemberian antibiotik dalam pengobatan sesuai, namun perlu dilakukan pembuatan clinical pathway agar penanganan bagi setiap pasien dapat memiliki panduan yang terstruktur.
Kata kunci: antibiotik; pneumonia; defined daily dose
Neural-network-based prediction of cryogenic BSIM4 model parameters from small datasets
Authors: Inaba Takumi , Chiashi Yusuke , Oka Hiroshi , Ogura Minoru , Asai Hidehiro , Iizuka Shota , Kato Kimihiko , Shitakata Shunsuke , Fuketa Hiroshi , Mori Takahiro 
Published: December 2024

Abstract
Neural-network-based prediction of BSIM4 model parameters for current-voltage (I-V) characteristics of short-channel bulk MOSFETs at 4 K was examined. Combining two neural network (NN) models and the least-squares method enabled the extraction of model parameters from only 4 experimentally obtained Id-Vg characteristics of 2 cryogenic MOSFETs, contributing to reducing time and financial costs for cryogenic device modeling. The proposed protocol provided lower root-mean-squared errors than the case where the least-squares method was solely employed. The superiority of the proposed protocol became evident as the number of model parameters increased, attributed to NNs providing good initial guesses for the least-squares method. As a result, cryogenic MOSFETs’ characteristics were fit by BSIM4 with the 6.6% error. This study also emphasizes the superiority of generative NN models over regression NN models for model parameter extraction by demonstrating the parameter extraction for highly correlated model parameters relating to threshold voltage.
DIREITO DE IMAGEM POST MORTEM E INTELIGÊNCIA ARTIFICIAL
Authors: Angelini Neta Ainah Hohenfeld , Borges Roxana Cardoso Brasileiro 
Published: December 2024

O rápido avanço das tecnologias nas últimas décadas tem permitido melhoras para a vida das pessoas nas mais diversas áreas, mas, ao mesmo tempo, suscita discussões sobre os eventuais perigos dessas inovações tecnológicas no que concerne à proteção dos direitos humanos. Nesta perspectiva, o presente trabalho se propõe a discutir os impactos do uso crescente da Inteligência Artificial (IA), especialmente no que diz respeito à recriação digital de imagens de pessoas post mortem por IA, o que tem sido chamado, também, de ressurreição digital. A preocupação diz respeito à criação de representações imagéticas que não foram condutas realizadas pela pessoa falecida, tal como o que aconteceu recentemente no Brasil numa campanha publicitária que trouxe a recriação da imagem da cantora Elis Regina ao lado da filha Maria Rita, suscitando a inquietação quanto aos limites do direito de imagem pertencente aos herdeiros, especialmente se este teria o condão de permitir a autorização para a criação de uma conduta jamais praticada pela pessoa falecida. Neste sentido, este trabalho se propõe a refletir sobre a proteção da imagem da pessoa falecida, analisando aspectos da regulação existente na União Europeia e no Brasil a respeito do tema, de modo a compreender os limites e possibilidades dessa “ressurreição digital”.
Riboflavin Spectrophotometric Determination with Zn(II) as a Choro Complex Anion using Cloud Point Extraction and HPLC in Different Drugs
Authors: Hanaa Abdullah Mohammed  , Safa Majeed Hameed  
Published: December 2024

Because riboflavin is becoming increasingly significant in the food, biological, and pharmaceutical fields, it is critical to accurately detect its content to guide nutritional health, diagnose and treat related diseases, conduct pharmacological research on riboflavin, and oversee the quality of food and drugs. A thorough application cloud point extraction and, liquid ion exchange in addition to HPLC techniques for the determination of riboflavin in pharmaceutical domains was provided. To produce an ion-pair association complex for RF with Zn(II) from HCl media and in the presence of Triton X-100 as non-ionic surfactant, the approach uses a liquid ion exchange process. The maximum wavelength was 295 nm. The influence of the ideal conditions on the separation process was examined: 95°C temperature, 15 min. of heating, 100µg/mL Zn(III) concentration, and TritonX-100 as the best surfactant. Within the concentration limit 5-1000μg/mL, the calibration curve is linear, with LOD of 6.07 μg/mL and LOQ of 18.38µg/mL. HPLC applied to compare the results with cloud point extraction and, liquid ion exchange in RF determination, they were identical.
PELATIHAN DAN PENDAMPINGAN WORKSHEET INTERAKTIF DENGAN WIZER.ME BAGI GURU SEKOLAH DASAR DI KOTA MALANG
Authors: Siregar Trio Erawati , Konten Gaundensius Jati Lamauran 
Published: December 2024

Pelatihan dan pendampingan pembuatan worksheet interaktif menggunakan wizer.me bertujuan untuk meningkatkan kompetensi guru sekolah dasar di Kota Malang dalam mengembangkan media pembelajaran digital. Kegiatan ini dilatarbelakangi oleh kebutuhan pembelajaran yang lebih inovatif di era digital sekaligus mengatasi keterbatasan guru dalam menggunakan teknologi. Pelaksanaan kegiatan melibatkan 10 guru sekolah dasar didukung oleh tim fasilitator yang memberikan pendampingan intensif. Kegiatan dilakukan melalui tiga tahapan utama yaitu persiapan, pelaksanaan, dan evaluasi. Tahap persiapan mencakup analisis kebutuhan peserta melalui observasi dan lembar angket. Pelatihan dilaksanakan dengan pendekatan praktis dimulai dari pengenalan wizer.me hingga pembuatan worksheet yang melibatkan elemen multimedia seperti teks, video, dan soal interaktif. Evaluasi menunjukkan bahwa pelatihan berhasil meningkatkan keterampilan teknis dan kepercayaan diri guru dalam memanfaatkan teknologi untuk pembelajaran. Hasil kegiatan ini mencakup worksheet interaktif yang sesuai dengan kebutuhan siswa lengkap dengan fitur evaluasi yang memudahkan proses penilaian. Pelatihan ini tidak hanya membekali guru dengan keterampilan baru tetapi juga mendorong inovasi dalam pembelajaran. Dengan keberhasilan ini, diharapkan guru-guru mampu terus beradaptasi dengan perkembangan teknologi dan meningkatkan kualitas pendidikan.
Pengaruh Media Video terhadap Peningkatan Pengetahuan dan Peran Ayah dalam Keberhasilan Menyusui di Kabupaten Cirebon
Authors: Nina Nirmaya Mariani  , Suratmi  , Lisnawati  
Published: December 2024

Latar Belakang : ASI merupakan bentuk makanan ideal bayi selama 6 bulan pertama kehidupan karena ASI menyediakan zat-zat gizi penting bagi pertumbuhan dan perkembangan. Banyak faktor yang mempengaruhi ketidakberhasilan dalam pemberian ASI, kurangnya pengetahuan dan dukungan dari orang disekitar atau terdekat ibu yaitu suami. Salah satu cara yang untuk meningkatkan pengetahuan dan perilaku atau peran ayah adalah pemberian pendidikan Kesehatan dengan metode dan media yang tepat agar sesuai dengan tujuan yang diharapkan. Berbagai penelitian menyatakan bahwa video lebih efektif dalam meningkatkan pengetahuan dan peran (perilaku). Tujuan : untuk menganalisis pengaruh media video dalam meningkatkan pengetahuan dan peran ayah dalam pemberian ASI di Kabupaten Cirebon. Metode : Penelitian analitik dengan pendekatan quasi eksperimen, rancangan one group pre and post design. Populasi adalah ayah yang memiliki bayi/balita usia 0-21 bulan. Jumlah sampel sebanyak 30 orang. Analisis univariate menggunakan nilai mean, median dan standar deviasi, analisis bivariate menggunakan uji Wilcoxon (Pengetahuan) dan paired t test (Peran Ayah), dan. Hasil : Terdapat perbedaan nilai rata-rata baik pada pengetahuan dan peran ayah. Berdasarkan uji analisis terdapat pengaruh media video baik terhadap pengetahuan dengan P Value 0,001 dan peran ayah dengan P Value 0,001. Kesimpulan : Terdapat pengaruh media video terhadap peningkatan pengetahuan dan peran ayah dalam keberhasilan menyusui. Penggunaan video dapat diterapkan dalam kelas ibu hamil dalam meningkatkan pengetahuan dan peran ayah ASI
Efektivitas Kombinasi Terapi Benson dan Aromaterapi terhadap Penurunan Stres Akademik pada Mahasiswa Keperawatan Universitas Respati Yogyakarta
Authors: Widayati Ririn Wahyu , Guterres Joaninha Da Costa , Sucipto Adi 
Published: December 2024

Latar Belakang: Stres akademik adalah stres yang disebabkan oleh ketidakmampuan siswa untuk menyesuaikan diri dengan persyaratan akademik yang dianggap wajib, dan ini dapat menimbulkan perasaan tidak nyaman yang memicu ketegangan fisik dan psikologis serta perubahan perilaku. Manajemen stres akademik non farmakologi yang dapat dilakukan untuk menangani stres akademik adalah dengan kombinasi Terapi benson dan Aromaterapi. Hasil studi pendahuluan yang dilakukan peneliti pada tanggal 25 Januari 2023 pada Mahasiswa Keperawatan dengan cara membagikan kuesioner dan wawancara secara daring kepada 10 responden. Dari hasil kuesioner dan wawancara ditemukan 2 responden yang mengalami stres sangat tinggi, stres sedang 4 orang, stres rendah 4 orang. Tujuan: Mengetahui efektivitas kombinasi Terapi Benson dan Aromaterapi terhadap penurunan stres akademik pada Mahasiswa Keperawatan Universitas Respati Yogyakarta. Metode Penelitian: Jenis penelitian ini adalah penelitian kuantitatif dengan Quasi experimental with control. Teknik pengambilan sampel yaitu Purposive sampling dan menggunakan kuesioner The Perception of Academic Scale (PASS), jumlah sampel 39 responden dibagi dua kelompok. Uji normalitas menggunakan Uji Shapiro Wilk. Analisa data uji bivariat menggunakan paired t test. Hasil: Skor stres akademik pada kelompok intervensi sebelum dan sesudah kombinasi terapi benson dan aromaterapi didapatkan nilai Mean 52,00 dan 44,21 . Skor stres akademik sebelum dan sesudah pada kelompok kontrol didapatkan nilai Mean 50,70 dan 50,65. Perbedaan stres akademik sebelum dan sesudah kelompok intervensi didapatkan nilai p 0,000 dan kelompok kontrol didapatkan nilai p value 0,744, dan Uji beda post-test antar kelompok didapatkan p-value adalah 0,008. Kesimpulan: Kombinasi terapi benson dan aromaterapi efektif dalam menurunkan stres akademik pada mahasiswa keperawatan Universitas Respati Yogyakarta
Importancia de la identificación del riesgo cardiovarscular genético en pacientes pediátricos
Authors: Sánchez-Vargas Juan Manuel , Moreno-Giraldo Lina Johanna 
Published: December 2024

Introducción: El hipercolesterolemia familiar (HF) es una enfermedad con herencia autosómico dominante, manifestándose en genotipos homocigoto (HFHo) o heterocigoto (HFHe). Se caracteriza por elevación de concentraciones plasmáticas de colesterol, particularmente niveles de colesterol de lipoproteína de baja densidad (LDL). Puede conducir a la formación de la placa aterosclerótica en las arterias coronarias y la aorta proximal a una edad temprana, aumentando el riesgo de eventos cardiovasculares prematuros de tipo angina e infarto agudo de miocardio.
El diagnóstico puede realizarse con dos aspectos: clínico y genético. Caso clínico: Presentamos el caso de un paciente adolescente asintomático con antecedentes familiares relevantes en primer y segundo grado de consanguinidad de enfermedad cardiovascular, hiperlipidemia de difícil manejo y muertes tempranas. Dado antecedentes familiares e importancia de descartar una enfermedad genética hereditaria asociada a riesgo cardiovascular, se solicitó perfil lipídico con resultados anormales de hiperlipidemia a expensas de LDL en plasma. Posterior a estos resultados, se solicitó un panel molecular de genes asociados a hipercolesterolemia, obteniendo variantes patogénicas en el gen que codifica los receptores para la LDL (LDLR) y en el gen de la proteína adaptadora 1 del receptor de LDL (LDLRAP1), ambos asociados al hipercolesterolemia familiar. Discusión y conclusión: Con este resultado, es posible realizar una adecuada intervención que sea predictiva, preventiva, personalizada y participativa. Puede instaurarse un tratamiento dirigido, realizar un adecuado seguimiento y asesoramiento genético, incluyendo riesgo de heredabilidad, búsqueda activa de otros posibles familiares portadores de la enfermedad, y así impactar en la morbilidad y mortalidad.