bluuebunny/crossref_metadata_2025_split huggingface dataset:
Rational Approach Towards Designing Metallogels From a Urea‐Functionalized Pyridyl Dicarboxylate: Anti‐inflammatory, Anticancer, and Drug Delivery
Authors: Sarkar Koushik , Dastidar Parthasarathi 
Published: October 2018

AbstractA structural rationale was adopted to design a series of metallogels from a newly synthesized urea‐functionalized dicarboxylate ligand, namely, 5‐[3‐(pyridin‐3‐yl)ureido]isophthalic acid (PUIA), that produces metallogels upon reaction with various metal salts (CuII, ZnII, CoII, CdII, and NiII salts) at room temperature. The gels were characterized by dynamic rheology and transmission electron microscopy (TEM). The existence of a coordination bond in the gel state was probed by FTIR and 1H NMR spectroscopy in a ZnII metallogel (i.e., MG2). Single crystals isolated from the reaction mixture of PUIA and CoII or CdII salts characterized by X‐ray diffraction revealed lattice inclusion of solvent molecules, which was in agreement with the hypothesis based on which the metallogels were designed. MG2 displayed anti‐inflammatory response (prostaglandin E2 assay) in the macrophage cell line (RAW 264.7) and anticancer properties (cell migration assay) on a highly aggressive human breast cancer cell line (MDA‐MB‐231). The MG2 metallogel matrix could also be used to load and release (pH responsive) the anticancer drug doxorubicin. Fluorescence imaging of MDA‐MB‐231 cells treated with MG2 revealed that it was successfully internalized.
Production of high crystallinity type‐I cellulose from Komagataeibacter hansenii JR‐02 isolated from Kombucha tea
Authors: Li Jue , Chen Guiguang , Zhang Ren , Wu Hao , Zeng Wei , Liang Zhiqun 
Published: October 2018

AbstractIn this study, a bacterial cellulose (BC) producing strain was isolated from Kombucha tea and identified as Komagataeibacter hansenii JR‐02 by morphological, physiological, and biochemical characterization and 16S rRNA sequence. Then, the media components and culture conditions for BC production were optimized. Result showed that the highest BC yield was 3.14 ± 0.22 and 8.36 ± 0.19 g/L after fermentation for 7 days under shaking and static cultivation, respectively. Moreover, it was interesting that JR‐02 could produce BC in nitrogen‐free medium with the highest yield of 0.76 ± 0.06 g/L/7days, and the possible nitrogen fixation gene nifH was cloned from its genomic DNA. The BC produced by JR‐02 was type‐I cellulose with high crystallinity and thermodynamic stability, which was revealed from Fourier transform infrared spectroscopy, X‐ray diffraction, and thermogravimetric analysis methods. The crystallinity of static and shaking cultured BC were 91.76% and 90.69%, respectively. The maximum rate of weight loss of static and shaking BC occurred at temperature of approximately 373.1 °C and 369.1 °C, respectively. Overall, these results indicated that K. hansenii JR‐02 had great potential to produce high crystallinity type‐I BC in manufacture.
Systematic review of shared decision-making in surgery
Authors: de Mik S M L , Stubenrouch F E , Balm R , Ubbink D T 
Published: October 2018

Abstract

Background
Multiple treatment options are generally available for most diseases. Shared decision-making (SDM) helps patients and physicians choose the treatment option that best fits a patient's preferences. This review aimed to assess the extent to which SDM is applied during surgical consultations, and the metrics used to measure SDM and SDM-related outcomes.

Methods
This was a systematic review of observational studies and clinical trials that measured SDM during consultations in which surgery was a treatment option. Embase, MEDLINE and CENTRAL were searched. Study selection, quality assessment and data extraction were conducted by two investigators independently.

Results
Thirty-two articles were included. SDM was measured using nine different metrics. Thirty-six per cent of 13 176 patients and surgeons perceived their consultation as SDM, as opposed to patient- or surgeon-driven. Surgeons more often perceived the decision-making process as SDM than patients (43·6 versus 29·3 per cent respectively). SDM levels scored objectively using the OPTION and Decision Analysis System for Oncology instruments ranged from 7 to 39 per cent. Subjective SDM levels as perceived by surgeons and patients ranged from 54 to 93 per cent. Patients experienced a higher level of SDM during consultations than surgeons (93 versus 84 per cent). Twenty-five different SDM-related outcomes were reported.

Conclusion
At present, SDM in surgery is still in its infancy, although surgeons and patients both think of it favourably. Future studies should evaluate the effect of new interventions to improve SDM during surgical consultations, and its assessment using available standardized and validated metrics.
Factors associated with physical inactivity in adult breast cancer survivors—A population‐based study
Authors: Huneidi Salam A. , Wright Nicole C. , Atkinson Arnisha , Bhatia Smita , Singh Purnima 
Published: October 2018

AbstractBackgroundPhysical activity has been shown to reduce the risk of breast cancer‐specific mortality. Although factors associated with physical inactivity in breast cancer survivors have been studied, a detailed examination at the population level is still lacking.MethodsWe addressed this gap in 1236 women with a diagnosis of breast cancer from the 2016 Behavioral Risk Factor Surveillance System Cancer Survivorship module. Physical inactivity was defined as self‐reported absence of leisure time physical activity. Factors examined in the multivariable logistic regression model included sociodemographic, behavioral factors, access to health care, health history, current cancer treatment, and pain from cancer or treatment.ResultsOverall, older age (≥65 years: OR = 2.63, 95% CI: 1.25‐5.55) and being underweight (BMI <18.5: OR = 6.11, 95% CI: 1.35‐27.66), were identified as significant factors associated with physical inactivity. In models adjusting for sociodemographics (Model 1), and the prior plus behavioral factors (Model 2), pain from cancer or treatment was significantly associated with physical inactivity (Model 2: OR = 2.23, 95% CI: 1.16‐4.28); however, after fully adjusting for all variables (Model 3), there was no longer evidence of a significant association between pain from cancer and physical activity in female survivors with breast cancer.ConclusionsWe identified demographic (older age) and physical (low BMI and pain) factors to be significantly associated with physical inactivity among breast cancer survivors. Future interventions to promote physical activity in breast cancer survivors could benefit by taking into account these factors to develop tailored recommendations for increasing activity.
Modulating Schottky Barrier of MoS2 to Enhance Hydrogen Evolution Reaction Activity by Incorporating with Vertical Graphene Nanosheets Derived from Organic Liquid Waste
Authors: Wu Angjian , Xu Aoni , Yang Jian , Li Xiaodong , Wang Li , Wang Jingfan , Macdonald Digby , Yan Jianhua 
Published: October 2018

AbstractThe lack of theoretical understanding of the reaction kinetics and the overall electrochemical system of the hydrogen evolution reaction (HER) is the major bottleneck for the design of highly efficient electrocatalysts. Here, we demonstrate that the current barrier between catalyst and current collector is strongly influencing the kinetic activation barrier at the catalyst‐electrolyte interface, and thus, equally important for the overall HER activity. Modulating the current collector/catalyst interface via introducing a layer of vertical graphene nanosheets (VGNS) derived from organic liquid waste is proposed as a feasible modification to lower the current barrier, while applying the concept of waste valorization. Benefiting from the intrinsically good electronic conductivity and low contact resistance at heterojunctions, VGNS plays an effective role in modulating the Schottky barrier contact to enhance HER activity. The enhancing effect is investigated by combining characterization, electrochemical measurements and density functional theory (DFT) calculation. By incorporating MoS2 with VGNS, the overpotential is reduced by ∼50 mV with a Tafel slope of 38 mV per decade. This is in accordance with the reduction of Schottky barrier height (SBH) from 0.52 to 0.23 eV in the model. Our results provide a new perspective into the role of Schottky barrier (contact resistance) on the activity origin of HER, which facilitates to establish a rational guidance for optimizing future electrocatalysts.
Tuning the NiO Thin Film Morphology on Carbon Nanotubes by Atomic Layer Deposition for Enzyme‐Free Glucose Sensing
Authors: Raza Muhammad H. , Movlaee Kaveh , Wu Yanlin , El‐Refaei Sayed M. , Karg Matthias , Leonardi Salvatore G. , Neri Giovanni , Pinna Nicola 
Published: October 2018

AbstractNanocomposites made of stacked‐cup carbon nanotubes coated with NiO (NiO/SCCNTs) via atomic layer deposition (ALD) were synthesized in order to obtain a material exhibiting enhanced and optimized electrochemical performance towards detections of glucose. The structure and morphology were characterized by transmission electron microscopy (TEM) and X‐ray diffraction (XRD). NiO deposited as nanocrystalline particles in the cubic modification, were well dispersed and directly anchored on SCCNTs forming a smooth particulate thin film, which becomes more dense with the increase of the number of ALD cycles. The NiO/SCCNTs samples with various thicknesses of the NiO coating (0.8 nm, 1.7 nm, 4.0 nm, 6.5 nm, 14.0 nm and 21.8 nm) were applied for enzyme‐free glucose sensing. Their electrochemical performance strongly depends on the thickness of the deposited NiO thin film. The best performing glucose sensors respond over a wide concentration range from 2 μM to 2.2 mM (R2=0.9979) with remarkably enhanced sensitivity (1252.3 μA cm−2 mM−1), with a limit of detection (LOD) of 0.10 μM (S/N=3) and with a fast response time (lower than 2 s). The significant performance improvement can be attributed to the conformal NiO coating, high surface to volume ratio and to the optimized thickness of the NiO thin film. The advantage of our sensors is also associated with the conductive supporting material (SCCNTs), simplicity of fabrication, high sensitivity, selectivity, stability and reproducibility for the rapid quantification of glucose.
An Approach towards the Synthesis of the Spiroimine Fragment of 13‐Desmethylspirolide C and Gymnodimine A
Authors: Guthertz Alexandre , Lusseau Jonathan , Desvergnes Valérie , Massip Stéphane , Landais Yannick 
Published: October 2018

AbstractA general access to the spiroimine skeleton of gymnodimine and spirolides is described, relying on the construction of the cyclohexene fragment using an enantiocontrolled Diels–Alder reaction, the installation of the all‐carbon quaternary stereocenter through a stereocontrolled alkylation or aldolisation and the elaboration of the lateral chains at C7 and C22 using Wittig–Horner olefinations. The spiroimine core of gymnodimine is made available through a 16‐step linear sequence in a 21 % overall yield.
Reaction engineering of the emulsion homopolymerization of vinylidene fluoride: Progress and challenges
Authors: Mendez Ecoscia Ana Carolina , Sheibat‐Othman Nida , McKenna Timothy F. L. 
Published: October 2018

AbstractThe emulsion polymerization of vinylidene fluoride (VDF) is used to produce a range of commercially important products. Despite this, the current review article will show that very little is known about the kinetics of polymerization, particle nucleation, and role of chain transfer reactions. This is at least in part due to the extreme conditions needed for the polymerization, which can significantly limit the number of academic laboratories able to enable such reactions.
Effort of ionic liquids with [HSO4]‐ on oxidative desulphurization of coal
Authors: Wang Lanyun , Li Zhendong , Jin Guosong , Zuo Ning , Xu Yongliang 
Published: October 2018

AbstractSulphur dioxide and soot produced during coal combustion are the main air pollution sources and increased emission of PM2.5 (particle matter with an aerodynamic diameter less than or equal to 2.5 µm) in China. In this investigation, two imidazolium ionic liquids (ILs), namely, 1‐butyl‐3‐methyl imidazolium bisulphate ([C4C1im][HSO4]) and 1‐carboxymethyl‐3‐methylimidazolium bisulphate([HOOCCH2mim][HSO4]), were used to remove sulphur from coal combined with 30 % hydrogen peroxide (H2O2) based on chemically oxidative desulphurization. The experimental results indicate that H2O2 played a dominant role in removing inorganic sulphur but only partially decreased organic sulphur. The [C4C1im][HSO4]‐H2O2 solution is able to remove 47.44 % of the total sulphur in coal and nearly 100 % of the inorganic sulphur while the [HOOCCH2mim][HSO4]‐H2O2 solution can remove 16.76 % of organic sulphur with a weaker ability to reduce inorganic components. According to the FTIR spectra analysis, the results show that the proportion of –SH, –CH3, –CH2–, and‐OH declined, while −COOH increased after the IL‐H2O2 treatment due to the oxidation enhancement in the presence of ionic liquids. Sulphur element compositions were measured using XPS, and the results also show that ionic liquids are favourable for improving the oxidation of –SH, –S–, and thiophene into sulphoxide and sulphone, which were extracted during the ionic liquid phase.
An Investigation into Rigidity–Activity Relationships in BisQAC Amphiphilic Antiseptics
Authors: Kontos Renee C. , Schallenhammer Stephanie A. , Bentley Brian S. , Morrison Kelly R. , Feliciano Javier A. , Tasca Julia A. , Kaplan Anna R. , Bezpalko Mark W. , Kassel W. Scott , Wuest William M. , Minbiole Kevin P. C. 
Published: October 2018

AbstractTwenty‐one mono‐ and biscationic quaternary ammonium amphiphiles (monoQACs and bisQACs) were rapidly prepared in order to investigate the effects of rigidity of a diamine core structure on antiseptic activity. As anticipated, the bioactivity against a panel of six bacteria including methicillin‐resistant Staphylococcus aureus (MRSA) strains was strong for bisQAC structures, and is clearly correlated with the length of non‐polar side chains. Modest advantages were noted for amide‐containing side chains, as compared with straight‐chained alkyl substituents. Surprisingly, antiseptics with more rigidly disposed side chains, such as those in DABCO‐12,12, showed the highest level of antimicrobial activity, with single‐digit MIC values or better against the entire bacterial panel, including sub‐micromolar activity against an MRSA strain.
Targeting Protein Kinase CK1δ with Riluzole: Could It Be One of the Possible Missing Bricks to Interpret Its Effect in the Treatment of ALS from a Molecular Point of View?
Authors: Bissaro Maicol , Federico Stephanie , Salmaso Veronica , Sturlese Mattia , Spalluto Giampiero , Moro Stefano 
Published: October 2018

AbstractRiluzole, approved by the US Food and Drug Administration (FDA) in 1995, is the most widespread oral treatment for the fatal neurodegenerative disorder amyotrophic lateral sclerosis (ALS). The drug, whose mechanism of action is still obscure, mitigates progression of the illness, but unfortunately with only limited improvements. Herein we report the first demonstration, using a combination of computational and in vitro studies, that riluzole is an ATP‐competitive inhibitor of the protein kinase CK1 isoform δ, with an IC50 value of 16.1 μm. This allows us to rewrite its possible molecular mechanism of action in the treatment of ALS. The inhibition of CK1δ catalytic activity indeed links the two main pathological hallmarks of ALS: transactive response DNA‐binding protein of 43 kDa (TDP‐43) proteinopathy and glutamate excitotoxicity, exacerbated by the loss of expression of glial excitatory amino acid transporter‐2 (EAAT2).
A conceptual framework and metrics for evaluating multicomponent interventions to increase colorectal cancer screening within an organized screening program
Authors: Subramanian Sujha , Hoover Sonja , Tangka Florence K. L. , DeGroff Amy , Soloe Cynthia S. , Arena Laura C. , Schlueter Dara F. , Joseph Djenaba A. , Wong Faye L. 
Published: October 2018

BackgroundMulticomponent, evidence‐based interventions are viewed increasingly as essential for increasing the use of colorectal cancer (CRC) screening to meet national targets. Multicomponent interventions involve complex care pathways and interactions across multiple levels, including the individual, health system, and community.MethodsThe authors developed a framework and identified metrics and data elements to evaluate the implementation processes, effectiveness, and cost effectiveness of multicomponent interventions used in the Centers for Disease Control and Prevention’s Colorectal Cancer Control Program.ResultsProcess measures to evaluate the implementation of interventions to increase community and patient demand for CRC screening, increase patient access, and increase provider delivery of services are presented. In addition, performance measures are identified to assess implementation processes along the continuum of care for screening, diagnosis, and treatment. Series of intermediate and long‐term outcome and cost measures also are presented to evaluate the impact of the interventions.ConclusionsUnderstanding the effectiveness of multicomponent, evidence‐based interventions and identifying successful approaches that can be replicated in other settings are essential to increase screening and reduce CRC burden. The use of common framework, data elements, and evaluation methods will allow the performance of comparative assessments of the interventions implemented across CRCCP sites to identify best practices for increasing colorectal screening, particularly among underserved populations, to reduce disparities in CRC incidence and mortality.
Evaluation of patient‐focused interventions to promote colorectal cancer screening among New York State Medicaid managed care patients
Authors: L. M. Dacus Heather , L. Wagner Victoria , A. Collins Elisè , M. Matson Jacqueline , Gates Margaret , Hoover Sonja , K. L. Tangka Florence , Larkins Teri , Subramanian Sujha 
Published: October 2018

BackgroundThe objective of this study was to evaluate an ongoing initiative to improve colorectal cancer (CRC) screening uptake in the New York State (NYS) Medicaid managed care population.MethodsPatients aged 50 to 75 years who were not up to date with CRC screening and resided in 2 NYS regions were randomly assigned to 1 of 3 cohorts: no mailed reminder, mailed reminder, and mailed reminder + incentive (in the form of a $25 cash card). Screening prevalence and the costs of the intervention were summarized.ResultsIn total, 7123 individuals in the Adirondack Region and 10,943 in the Central Region (including the Syracuse metropolitan area) were included. Screening prevalence in the Adirondack Region was 7.2% in the mailed reminder + incentive cohort, 7.0% in the mailed reminder cohort, and 5.8% in the no mailed reminder cohort. In the Central Region, screening prevalence was 7.2% in the mailed reminder cohort, 6.9% in the mailed reminder + incentive cohort, and 6.5% in the no mailed reminder cohort. The cost of implementing interventions in the Central Region was approximately 53% lower than in the Adirondack Region.ConclusionsScreening uptake was low and did not differ significantly across the 2 regions or within the 3 cohorts. The incentive payment and mailed reminder did not appear to be effective in increasing CRC screening. The total cost of implementation was lower in the Central Region because of efficiencies generated from lessons learned during the first round of implementation in the Adirondack Region. More varied multicomponent interventions may be required to facilitate the completion of CRC screening among Medicaid beneficiaries.
Feasibility of fine‐needle aspiration for assessing responses to chemotherapy in metastatic nodes marked with clips in breast cancer: A prospective registry study
Authors: Caudle Abigail S. , Kuerer Henry M. , Krishnamurthy Savitri , Shin Kyungmin , Hobbs Brian P. , Ma Junsheng , Mittendorf Elizabeth A. , Washington Ashley C. , DeSnyder Sarah M. , Black Dalliah M. , Hunt Kelly K. , Yang Wei T. 
Published: October 2018

BackgroundClips are often placed to mark axillary nodes with biopsy‐confirmed metastases in patients with breast cancer. The evaluation of clipped nodes after chemotherapy can identify patients who have eradication of nodal disease. The goal of this study was to determine whether preoperative fine‐needle aspiration (FNA) of clipped nodes after neoadjuvant chemotherapy (NAC) could predict the presence of residual disease.MethodsThis prospective registry study enrolled 50 patients with a clip placed to mark nodes with biopsy‐confirmed metastases who had completed NAC. Participants underwent FNA of the clipped node before seed‐localized lymph node excision. FNA pathology was compared with surgical pathology.ResultsThere were 36 patients (72%) with residual disease on surgical pathology: 3 (8%) had a nondiagnostic aspirate, carcinoma was seen in 14 (39%), and 19 (53%) had a false‐negative result. The sensitivity of FNA was 42.4%, its specificity was 100%, and its negative predictive value was 40.6%. In a univariate analysis, the odds of a true‐positive result increased significantly with the mean initial size of the clipped node (odds ratio [OR], 4.3; P = .004) and the size of the metastatic focus after NAC (OR, 1.3; P = 0.003), whereas normalization of nodes after chemotherapy (OR, 0.1) and a lack of response on ultrasound (OR, 0.11) were associated with a false‐negative result (P = .01).ConclusionsFNA of marked nodes after chemotherapy has a high false‐negative rate. This highlights the need for surgical staging of the axilla after NAC to assess the response.
A computational model for microcirculation including Fahraeus‐Lindqvist effect, plasma skimming and fluid exchange with the tissue interstitium
Authors: Possenti Luca , di Gregorio Simone , Gerosa Fannie Maria , Raimondi Giorgio , Casagrande Giustina , Costantino Maria Laura , Zunino Paolo 
Published: October 2018

AbstractWe present a two‐phase model for microcirculation that describes the interaction of plasma with red blood cells. The model takes into account of typical effects characterizing the microcirculation, such as the Fahraeus‐Lindqvist effect and plasma skimming. Besides these features, the model describes the interaction of capillaries with the surrounding tissue. More precisely, the model accounts for the interaction of capillary transmural flow with the surrounding interstitial pressure. Furthermore, the capillaries are represented as one‐dimensional channels with arbitrary, possibly curved configuration. The latter two features rely on the unique ability of the model to account for variations of flow rate and pressure along the axis of the capillary, according to a local differential formulation of mass and momentum conservation. Indeed, the model stands on a solid mathematical foundation, which is also addressed in this work. In particular, we present the model derivation, the variational formulation, and its approximation using the finite element method. Finally, we conclude the work with a comparative computational study of the importance of the Fahraeus‐Lindqvist, plasma skimming, and capillary leakage effects on the distribution of flow in a microvascular network.