bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fatigue and recovery in ballet: Exploring the experiences of professional South African ballet dancers
Authors: Smith Lania-Schane , Louw Quinette Abigail , Brink Yolandi 
Published: December 2024

Abstract
Background
Professional South African ballet dancers face a higher risk of overuse injuries and overtraining syndrome as compared to dancers from other countries; especially towards the end of a ballet season. Fatigue is a major factor leading to overtraining syndrome and injuries in professional ballet dancers. The study aimed to explore the fatigue and recovery experiences of South African ballet dancers, highlighting how they navigate these aspects and the strategies they employ for recovery.

Methods
Snowball sampling was employed to recruit ten professional South African ballet dancers. Between March and June 2023, individual semi-structured interviews were conducted online using Microsoft Teams. The interview schedule, informed by previous research, delved into the dancers’ fatigue and recovery experiences. Interviews were recorded, transcribed, and analysed using inductive thematic analysis.

Results
Seven main themes were developed from the data. Participants distinguished between mental and physical fatigue, highlighting the impact of mental fatigue on their well-being. They identified factors contributing to fatigue, including high external pressure, motivated behaviours, and expectations from audiences and management. These contributors often resulted in injuries, mandatory breaks, and sub-optimal performance. Participants accepted fatigue as inherent to their profession, emphasising mental resilience. Recovery practices included psychological, nutritional, and active strategies. The COVID-19 lockdown provided a respite from external pressures, allowing for improved recovery, but participants faced challenges upon returning to work. Gradually increasing practice time and exposure to external pressures assisted ballet dancers in effectively managing fatigue and enhancing their recovery as they returned to work.

Conclusion
This study offers a perspective of fatigue and recovery in a sample of professional ballet dancers in South Africa. It emphasises the ongoing significance of fatigue and recovery and the necessity for effective strategies by arts organisations, mental health professionals, and academic researchers to support artists. The insights gained from this research could be crucial in redesigning training programs for dancers, adjusting training intensity and volume to enhance performance, and promoting recovery. Furthermore, this information serves as a strong rationale for adopting a holistic approach to fatigue and recovery, emphasising the importance of a collaborative effort to address these aspects effectively.
Sort & Slice: a simple and superior alternative to hash-based folding for extended-connectivity fingerprints
Authors: Dablander Markus , Hanser Thierry , Lambiotte Renaud , Morris Garrett M. 
Published: December 2024

AbstractExtended-connectivity fingerprints (ECFPs) are a ubiquitous tool in current cheminformatics and molecular machine learning, and one of the most prevalent molecular feature extraction techniques used for chemical prediction. Atom features learned by graph neural networks can be aggregated to compound-level representations using a large spectrum of graph pooling methods. In contrast, sets of detected ECFP substructures are by default transformed into bit vectors using only a simple hash-based folding procedure. We introduce a general mathematical framework for the vectorisation of structural fingerprints via a formal operation called substructure pooling that encompasses hash-based folding, algorithmic substructure selection, and a wide variety of other potential techniques. We go on to describe Sort & Slice, an easy-to-implement and bit-collision-free alternative to hash-based folding for the pooling of ECFP substructures. Sort & Slice first sorts ECFP substructures according to their relative prevalence in a given set of training compounds and then slices away all but the L most frequent substructures which are subsequently used to generate a binary fingerprint of desired length, L. We computationally compare the performance of hash-based folding, Sort & Slice, and two advanced supervised substructure-selection schemes (filtering and mutual-information maximisation) for ECFP-based molecular property prediction. Our results indicate that, despite its technical simplicity, Sort & Slice robustly (and at times substantially) outperforms traditional hash-based folding as well as the other investigated substructure-pooling methods across distinct prediction tasks, data splitting techniques, machine-learning models and ECFP hyperparameters. We thus recommend that Sort & Slice canonically replace hash-based folding as the default substructure-pooling technique to vectorise ECFPs for supervised molecular machine learning. Scientific contributionA general mathematical framework for the vectorisation of structural fingerprints called substructure pooling; and the technical description and computational evaluation of Sort & Slice, a conceptually simple and bit-collision-free method for the pooling of ECFP substructures that robustly and markedly outperforms classical hash-based folding at molecular property prediction.
Ramifications of flipped classroom model on second language teachers’ professional identity in Turkish tertiary hybrid education context
Authors: Şan Nalan 
Published: December 2024

AbstractAs the traditional teaching paradigm is reversed in Flipped Classroom Model (FCM), it has the potential to empower the teacher to allocate more valuable face-to-face classroom time for productive language tasks. Digital flipped course contents encourage the students and the teacher to take advantage of becoming a member in an online learning community and engage in a social-constructive learning approach. Such a profound shift from the traditional teaching and learning paradigm may influence the identity progression of L2 teachers. This longitudinal study aims to explore the ramifications of flipped grammar teaching on four L2 teachers’ identity progression over the course of two academic years within the three fundamental modes of belonging for identity formation, namely engagement, alignment, and imagination, identified by Wenger (1999) at tertiary level. Methodological triangulation was adopted to boost the transferability and reliability of the findings. Semi-structured interviews provided in-depth insights into the four L2 teachers’ relational thinking about flipped grammar teaching and their professional identity progression. The data also included four hours of classroom observations to witness the real-life implications of teachers’ accounts. The twofold data was analyzed using deductive content analysis. The results indicated that English teachers need to make long lasting and conscious efforts towards a reconciliation between their existing identities and FCM. The teachers not only need to find accommodation strategies to ensure better integration of reluctant students into FCM but also overcome their own accuracy-based exam anxiety as they redefine their grammar identities incorporating FCM.
Transcriptomic analysis delineates potential regulatory network as therapeutic alternatives in chronic myeloid leukemia
Authors: Tasneem Alvea , Sharma Archana , Syed Mansoor Ali , Dohare Ravins 
Published: December 2024

Abstract
Background
Chronic myeloid leukemia (CML) relapse and progression after discontinuation of tyrosine kinase inhibitors (TKI) therapy in the chronic phase (CP) are attributed to primitive quiescent leukemic progenitor cells (LPCs). This study aimed to identify key differentially expressed genes (DEGs) involved in molecular pathways alternative to BCR-ABL, which could lead to the eradication of leukemic stem/progenitor cells.

Methods
mRNA expression profiling dataset comprising newly diagnosed untreated CP CML leukemic progenitor cell samples $$\left( {n = 5} \right)$$

n
=
5

and normal hematopoietic progenitor cell samples $$\left( {n = 5} \right)$$

n
=
5

were selected for DEGs identification. A weighted gene co-expression network was constructed to identify significant hub modules. Protein–protein interaction (PPI) network construction and pathway enrichment analysis provided additional information on the biological pathways involved. The genes involved in the resultant PPI network were subjected to a gene transcriptional regulatory network based on transcription factors (TFs) and microRNAs (miRNAs) involved in the target genes.

Results
A total of 709 genes that were differentially expressed among those corresponding to $$p < 0.05$$

p
<
0.05

and $$\left| {\log_{2} \left( {FC} \right)} \right| > 0.5$$

log
2

FC

>
0.5

. The WGCNA showed a significant hub module comprising 267 DEGs. The major pathways of the hub genes involved in the PPI network at the highest confidence score $$> 0.9$$

>
0.9

were related to mitochondrial translational elongation. The integrated gene transcriptional regulatory network revealed a TF (ETS1), two miRNAs (miR-34a-5p and miR-205-5p) targeting a hub gene (GFM1) as the highest-order motif or subnetwork in the three-node miRNA feed-forward loop.

Conclusions
The study suggests that the regulatory feed-forward loop may provide a potential therapeutic target in CML. Consequently, the mitochondrial translation pathway may be explored as an alternative to BCR-ABL pathways, which could aid in eliminating or increasing sensitization of CML progenitor/stem cells to TKI treatment.
Psychiatrists’ reactions to a patient’s suicide – narrative review
Authors: Wingralek Zuzanna Joanna , Kasprzak Karol , Dyzma-Kasprzak Agnieszka , Juchnowicz Dariusz , Karakuła-Juchnowicz Hanna 
Published: December 2024

WstępSamobójstwo pacjenta może mieć głęboki wpływ na stan emocjonalny i praktykę zawodową klinicystów, którzy byli zaangażowani w opiekę nad pacjentem. Celem pracy było: 1) określenie rozpowszechnienia doświadczenia śmierci samobójczej pacjenta przez psychiatrę, 2) porównanie reakcji lekarzy na śmierć pacjenta uwarunkowaną różnymi przyczynami, 3) określenie wpływu samobójstwa pacjenta na stan emocjonalny i praktykę zawodową psychiatrów, 4) wskazanie możliwych interwencji i wsparcia psychicznego lekarzy.Materiał i metodyDokonano przeglądu literatury w języku polskim oraz angielskim, używając słów kluczy: samobójstwo pacjenta, reakcja psychiatrów, wsparcie psychiczne (ang. patient suicide, reaction of psychiatrists, mental support), przeszukując bazy PubMed/MEDLINE oraz Google Scholar w okresie do 7 marca 2024 roku. Analizie poddano łącznie 56 publikacji, w tym 41 oryginalnych prac badawczych i 15 prac przeglądowych, wykorzystując skalę SANRA do zapewnienia jakości przeglądu narracyjnego.WynikiSamobójstwa pacjenta doświadczyło w swojej praktyce od 38,8% o 91,5% psychiatrów, co w wiązało się z następującymi konsekwencjami: 1. zmianą stanu emocjonalnego (pojawienie się smutku, lęku, niedowierzania, złości, żalu, wstydu; rzadziej- rozwojem ostrej reakcji na stres, zespołu stresu pourazowego), 2. wpływie na praktykę zawodową (zwątpienie w swoje kompetencje, strach przed odpowiedzialnością zawodową oraz krytyką, zwiększenie liczby konsultacji, nadmiernie nasilone przestrzeganie środków bezpieczeństwa, zbyt częste i długie hospitalizacje pacjentów). Odpowiednie wsparcie psychiczne, w tym szczególnie ze strony bardziej doświadczonych kolegów oraz osób najbliższych, wpływało na redukcję negatywnych konsekwencji wśród lekarzy.WnioskiBiorąc pod uwagę dużą skalę zjawiska istotne jest zauważenie problemu ogromnego obciążenia emocjonalnego psychiatrów śmiercią samobójczą pacjenta oraz wpływu na ich praktykę zawodową, a także budowanie sprawnego systemu szkoleń i wsparcia psychicznego.
Defining the extracellular matrix in non-cartilage soft-tissues in osteoarthritis: a systematic review
Authors: Raza Iwan G. A. , Snelling Sarah J. B. , Mimpen Jolet Y. 
Published: December 2024

AimsExtracellular matrix (ECM) is a critical determinant of tissue mechanobiology, yet remains poorly characterized in joint tissues beyond cartilage in osteoarthritis (OA). This review aimed to define the composition and architecture of non-cartilage soft joint tissue structural ECM in human OA, and to compare the changes observed in humans with those seen in animal models of the disease.MethodsA systematic search strategy, devised using relevant matrix, tissue, and disease nomenclature, was run through the MEDLINE, Embase, and Scopus databases. Demographic, clinical, and biological data were extracted from eligible studies. Bias analysis was performed.ResultsA total of 161 studies were included, which covered capsule, ligaments, meniscus, skeletal muscle, synovium, and tendon in both humans and animals, and fat pad and intervertebral disc in humans only. These studies covered a wide variety of ECM features, including individual ECM components (i.e. collagens, proteoglycans, and glycoproteins), ECM architecture (i.e. collagen fibre organization and diameter), and viscoelastic properties (i.e. elastic and compressive modulus). Some ECM changes, notably calcification and the loss of collagen fibre organization, have been extensively studied across osteoarthritic tissues. However, most ECM features were only studied by one or a few papers in each tissue. When comparisons were possible, the results from animal experiments largely concurred with those from human studies, although some findings were contradictory.ConclusionChanges in ECM composition and architecture occur throughout non-cartilage soft tissues in the osteoarthritic joint, but most of these remain poorly defined due to the low number of studies and lack of healthy comparator groups.Cite this article: Bone Joint Res 2024;13(12):703–715.
Inhibitory effect of Zhujing Pill on myopia progression: Mechanistic insights based on metabonomics and network pharmacology
Authors: Du Yongle , Pang Mengran , Chen Haoyu , Zhou Xiangkun , Geng Ruyue , Zhang Yanan , Yang Linqi , Li Jiawen , Han Yufeng , Liu Jinpeng , Zhang Ruixue , Bi Hongsheng , Guo Dadong 
Published: December 2024

Objectives
This study endeavored to uncover the mechanisms by which Zhujing pill (ZJP) slows myopia progression.

Methods
We employed biometric analyses to track diopter and axial length changes in guinea pigs with negative lens-induced myopia (LIM). Through integrating metabonomics and network pharmacology, we aimed to predict the anti-myopic targets and active ingredients of ZJP. Subsequent analysis, including real-time fluorescent quantitative PCR (qPCR) and Western blotting (WB), assessed the expression levels of CHRNA7, LPCAT1, and NOS2 in retinal tissues.

Key findings
Our findings demonstrate that ZJP significantly mitigates diopter increase and axial elongation in LIM guinea pigs. Metabonomic analysis revealed significant changes in 13 serum metabolites, with ZJP reversing the expression of 5 key metabolites. By integrating metabonomics with network pharmacology, we identified core targets of ZJP against myopia and constructed a compound-gene-disease-metabolite network. The expressions of LPCAT1 and CHRNA7 were found to decrease in the LIM group but increase with ZJP treatment, whereas NOS2 expression showed the opposite pattern.

Conclusions
This investigation provides the first evidence of ZJP’s multifaceted effectiveness in managing myopia, highlighting its impact on multiple components, targets, and pathways, including the novel involvement of LPCAT1 and CHRNA7 in myopia pathogenesis.
Personal and workplace factors influencing the resilience of nurses caring for women with cervical cancer in a resource-constrained setting in Ghana
Authors: Oware Jennifer , Iddrisu Merri , Konlan Kennedy Dodam , Dzansi Gladys 
Published: December 2024

Introduction
Cervical cancer has been identified as the fourth most common form of malignancy affecting and killing women globally. Nurses caring for cervical cancer patients are exposed to emotional and psychological distress due to late presentation and the burden of care. Resilience has been identified as one of the effective ways of helping nurses to cope well with the stress of oncology nursing, but this remains undetermined in Ghana

Aim
This study explored personal and workplace factors influencing the resilience of nurses caring for women diagnosed with advanced cervical cancer (stage III and IV) in a resource-constrained setting in Ghana

Method
Using a qualitative approach, we recruited twenty nurses and midwives who had worked for a year and above caring for advanced-stage cervical cancer patients at the national referral hospital in Ghana. We conducted in-depth interviews between July, 2022 to September, 2022 which were audio-taped with participants’ consent. Transcription was done verbatim, and analysis conducted using thematic analysis approach with the aid of NVivo 10.0.

Results
The results revealed experience as a safety toolkit, inherent desire to help/care for the patient, emotional numbness and maintaining professional outlook as personal factors influencing resilience among the participants. Regarding the workplace factors influencing resilience, we identified the main theme of demands of caregiving for advanced cervical cancer patients with the following sub-themes; severity of cases managed, nature of care rendered, activities of care given, reshuffling, schedules and gender mirroring as an exacerbator of psychological suffering.

Conclusion
Resilience among nurses and midwives caring for terminally ill cervical cancer patients is influenced by longer years of service, intrinsic motivation to work as a nurse, and the defense strategy of emotional numbness and professionalism at the individual level. Also, the huge demand of caregiving serves as a major workplace factor affecting the resilience of nurses and midwives. We recommend strategies such as regular ward conferences and in-service trainings aimed at enhancing job-experience, inherent desire to render care and professionalism be adopted in resource-constrained settings to improve nurses’ resilience. In addition, political actors and management of hospitals must prioritize allocation of resources for advanced cervical cancer care with particular focus on providing more specialized nurses and midwives.
Strengthening local academic publishing in the age of academic fast fashion [TILAMSIK]
Authors: Guinto Nicanor L. 
Published: December 2024

Abstract
Drawing upon Wolfgang Klein’s concerns from 1989 about the overwhelming pace of academic publications and its shrinking readership, this commentary proposes strengthening local academic publishers to mitigate the impact of “academic fast fashion” – an ensuing phenomenon within the market-oriented academic landscape characterized by the rapid production, consumption, and disposal of scientific knowledge. By reflecting on our experience of establishing and maintaining local academic journals in Southern Luzon, Philippines, I illustrate the challenges that can be faced in this endeavor. I argue that if given proper support by appropriate academic infrastructures, local academic publishing can tap into a diverse audience to distill competition in readership apparent in today’s globally-oriented academic landscape while simultaneously cultivating local knowledge economies. Opening academic discourse to unconventional readers through local academic publications can thus fulfill Klein’s vision for a more inclusive advancement of knowledge.
Meritocracy, governmental intervention, and academic nepotism: a South Korean academic publishing landscape [The Sociolinguistic Journal of Korea]
Authors: Kim Hojung , Baek Seungjoo , Jang In Chull 
Published: December 2024

Abstract
While engaging with Klein’s (1989. Schreiben oder Lesen, aber nicht beides, oder: Vorschlag zur Wiedereinführung der Keilschrift mittels Hammer und Meißel. Zeitschrift für Literaturwissenschaft und Linguistik 74. 116–119) suggestions to control the quantity of publications, this brief paper explores the reasons behind the intense publishing pressure on South Korean scholars and examines the consequences for the development of an academic public sphere. We underscore that the evaluation systems of neoliberal universities, which prioritize quantity and speed, together with a social concern with “fairness,” compel researchers to embrace a meritocratic ethos. This is further intensified by the multiple excellence benchmarks set by government research agencies. Moreover, the prevalence of insular academic networks, often formed by individuals from elite backgrounds, restricts the circulation of scholarly work within exclusive groups. Consequently, the academic environment in South Korea struggles to cultivate an academic public sphere that tackles critical issues and encourages productive debates. In response to these challenges, we propose to adopt the principles of the “slow professor” movement, foster collaboration with practitioners, and diversify scholarly genres.
Wolfgang Klein as Don Quixote [Journal of Multilingual and Multicultural Development]
Authors: Dewaele Jean-Marc 
Published: December 2024

Abstract
Wolfgang Klein’s paper Writing or reading, but not both, or: a proposal reintroduce cuneiform writing using the hammer and chisel is a great example of ex absurdo reasoning to introduce very serious questions about the exponential increase in the quantity of publications in our field and the impossibility of keeping up with everything. The proposed solutions to limit output and enhance its quality are humourous and absurd as they are inoperable. Wolfgang Klein adopts the position of Don Quixote charging windmills in Cervante’s El ingenioso hidalgo Don Quijote de la Mancha published in the early seventeenth century. I argue that researchers are free to read and write as much as they want about any topic that fascinates them. Doing so judiciously will allow them to thrive.
Where global discourses meet local realities: the case of scholarly publishing in Sinhala [Sāhityaya]
Authors: Rambukwella Harshana , Fedricks Krishantha , Perera Kaushalya 
Published: December 2024

Abstract
Scholarly publishing in the Sinhala language (the language of the numerical majority in Sri Lanka) has “mushroomed” in the recent past. However, this rapid growth – fueled by instrumental professional needs, the mainstreaming of a metrics-based culture in the university system, and neo-liberal discourses about measurable academic productivity – we argue is of little intellectual consequence. We trace a history of how a vibrant Sinhala-language public culture emerged in the nineteenth and early twentieth centuries within a larger history of decolonization; how this public culture became institutionalized within the postcolonial state from the late 1940s; and how Sinhala language publishing lost its state patronage in the 1980s with neo-liberalization which ironically created space for radical Sinhala-language intellectual debate. We conclude by contrasting this history with the present where Sinhala scholarly publishing has become banal and faces an existential threat from the “return” of English due to neo-liberal market forces.