bluuebunny/crossref_metadata_2025_split huggingface dataset:
Turning things around? From white fusion stars with Andean flavour to Andean fusion stars with white appeal
Authors: Montero-Diaz Fiorella 
Published: September 2018

AbstractPopular fusion music in Peru's capital Lima has in recent years grown into a representative genre challenging existing segregation of Limeño society through interethnic and interclass interaction. Focusing on three case studies of Peruvian fusionists performing for the white upper classes, this article documents a shift in racialised notions of Andeanness and marginality among the white upper classes from 1960 to 2014, linking the changes in perception to the political and social context of those years. It examines the trajectories of Miki González (an older white fusion star who hires Andean musicians), La Sarita (an intercultural Andean rock band striving to balance the urban and the Andean) and Magaly Solier (a young Andean campesina (‘peasant’) actress and singer who hires white musicians). These case studies demonstrate how fusion music interactions contribute to re-shaping traditional cultural imaginaries, challenge racism, and project images of empowerment onto 21st century Andeans.
Geodesic X-ray tomography for piecewise constant functions on nontrapping manifolds
Authors: ILMAVIRTA JOONAS , LEHTONEN JERE , SALO MIKKO 
Published: September 2018

AbstractWe show that on a two-dimensional compact nontrapping manifold with strictly convex boundary, a piecewise constant function is determined by its integrals over geodesics. In higher dimensions, we obtain a similar result if the manifold satisfies a foliation condition. These theorems are based on iterating a local uniqueness result. Our proofs are elementary.
A school- and community-based intervention to promote healthy lifestyle and prevent type 2 diabetes in vulnerable families across Europe: design and implementation of the Feel4Diabetes-study
Authors: Manios Yannis , Androutsos Odysseas , Lambrinou Christina-Paulina , Cardon Greet , Lindstrom Jaana , Annemans Lieven , Mateo-Gallego Rocio , de Sabata Maria Stella , Iotova Violeta , Kivela Jemina , Martinez Remberto , Moreno Luis A , Rurik Imre , Schwarz Peter , Tankova Tsvetalina , Liatis Stavros , Makrilakis Konstantinos 
Published: September 2018

AbstractObjectiveTo describe the design of the Feel4Diabetes-intervention and the baseline characteristics of the study sample.DesignSchool- and community-based intervention with cluster-randomized design, aiming to promote healthy lifestyle and tackle obesity and obesity-related metabolic risk factors for the prevention of type 2 diabetes among families from vulnerable population groups. The intervention was implemented in 2016–2018 and included: (i) the ‘all-families’ component, provided to all children and their families via a school- and community-based intervention; and (ii) an additional component, the ‘high-risk families’ component, provided to high-risk families for diabetes as identified with a discrete manner by the FINDRISC questionnaire, which comprised seven counselling sessions (2016–2017) and a text-messaging intervention (2017–2018) delivered by trained health professionals in out-of-school settings. Although the intervention was adjusted to local needs and contextual circumstances, standardized protocols and procedures were used across all countries for the process, impact, outcome and cost-effectiveness evaluation of the intervention.SettingPrimary schools and municipalities in six European countries.SubjectsFamilies (primary-school children, their parents and grandparents) were recruited from the overall population in low/middle-income countries (Bulgaria, Hungary), from low socio-economic areas in high-income countries (Belgium, Finland) and from countries under austerity measures (Greece, Spain).ResultsThe Feel4Diabetes-intervention reached 30 309 families from 236 primary schools. In total, 20 442 families were screened and 12 193 ‘all families’ and 2230 ‘high-risk families’ were measured at baseline.ConclusionsThe Feel4Diabetes-intervention is expected to provide evidence-based results and key learnings that could guide the design and scaling-up of affordable and potentially cost-effective population-based interventions for the prevention of type 2 diabetes.
Earthquake Damage Patterns Resolve Complex Rupture Processes
Authors: Klinger Yann , Okubo Kurama , Vallage Amaury , Champenois Johann , Delorme Arthur , Rougier Esteban , Lei Zhou , Knight Earl E. , Munjiza Antonio , Satriano Claudio , Baize Stephane , Langridge Robert , Bhat Harsha S. 
Published: September 2018

AbstractFracture damage patterns around faults induced by dynamic earthquake rupture are an invaluable record to clarify the rupture process on complex fault networks. The 2016 Mw 7.8 Kaikōura earthquake in New Zealand has been reported as one of the most complex earthquakes ever documented that ruptured at least 15 crustal faults. High‐resolution optical satellite image displacement maps provide distinctive profiles of displacement across the faults and help visualize the off‐fault damage pattern. They are combined with field observation and coupled with a numerical tool that captures the dynamics of the rupture and simultaneous activation of off‐fault damage to allow the determination of the most likely rupture scenario. This study demonstrates that complex rupture processes can be explained in a rather simple way via a synergetic combination of state‐of‐the‐art observation and first principle physics‐based numerical modeling of off‐fault damage.
Proxy‐Based Assessment of Strength and Frequency of Meteotsunamis in Future Climate
Authors: Vilibić Ivica , Šepić Jadranka , Dunić Natalija , Sevault Florence , Monserrat Sebastian , Jordà Gabriel 
Published: September 2018

AbstractA climate synoptic meteotsunami index has been constructed using synoptic variables for the Balearic Islands. The index allows for the very first assessment of atmospherically driven intense sea level oscillations at the tsunami timescale (<2 hr) in future climates. The index has been computed using outputs from evaluation, historical, and three scenario MED‐11_CNRM Med‐CORDEX regional atmospheric climate runs. The reliability of the index has been verified against reanalysis simulations and on documented meteotsunami events. No significant changes in the index are projected under RCP2.6 and RCP4.5 scenarios, while the yearly number of days with meteotsunamis is expected to increase by 34% under the RCP8.5 scenario by the year 2100. This increase will dominantly occur during the summer season (May–August), being contemporaneous with maximum index values. The presented results are relevant for assessment of sea level extremes worldwide, since high‐frequency sea level oscillations may contribute up to 40% of the total range.
Whistler and Electron Firehose Instability Control of Electron Distributions in and Around Dipolarizing Flux Bundles
Authors: Zhang Xu , Angelopoulos V. , Artemyev A. V. , Liu Jiang 
Published: September 2018

AbstractElectromagnetic fluctuations associated with various plasma instabilities have been previously identified near dipolarization fronts in Earth's magnetotail. However, the potential effect of these fluctuations on particle distributions and energy conversion is poorly understood. The most important instabilities responsible for electron acceleration and scattering are the whistler instability and the electron firehose instability. Utilizing 10 years of Time History of Events and Macroscale Interactions during Substorms satellite observations, we explore the occurrence probability and intensity of these instabilities near dipolarization fronts, as function of electron anisotropy and plasma beta. Electron temperature anisotropies are well constrained by the marginal stability conditions of the whistler and oblique electron firehose instabilities. In fact, the observed enhancement of magnetic field fluctuations near the instability thresholds provides good evidence for the operation of these instabilities on electrons near fronts. Since the build‐up of electron anisotropy is limited by wave‐particle interactions, we conclude that such interactions are important enough to affect electron dynamics and energetics.
PARP-1-dependent RND1 transcription induced by topoisomerase I cleavage complexes confers cellular resistance to camptothecin
Authors: Mouly Laetitia , Mamouni Kenza , Gence Remi , Cristini Agnese , Cherier Julia , Castinel Adrien , Legrand Morgane , Favre Gilles , Sordet Olivier , Monferran Sylvie 
Published: September 2018

AbstractRHO GTPases regulate essential functions such as the organization of the actin cytoskeleton. The classic members cycle between an active GTP-bound and an inactive GDP-bound conformation whereas atypical members are predominantly GTP-bound. Besides their well-established role, the classic RHO GTPases RHOB and RAC1, are rapidly induced and/or activated by genotoxic stress and contribute to the DNA damage response. Here we used camptothecin, a selective topoisomerase I (TOP1) inhibitor that stabilizes TOP1 cleavage complexes (TOP1cc), to search for other potential early DNA damage-inducible RHO GTPase genes. We identified that an atypical RHO GTPase, RND1, is rapidly induced by camptothecin. RND1 induction is closely associated with the presence of TOP1cc induced by camptothecin or by DNA lesions that elevate TOP1cc levels such as UV and hydrogen peroxide. We further demonstrated that camptothecin increases RND1 gene transcription and mRNA stability. Camptothecin also increases poly(ADP-ribose) polymerase 1 (PARP-1) activity, whose inhibition reduces RND1 transcription. In addition, overexpression of RND1 increases PARP-1, suggesting a cross-talk between PARP-1 and RND1. Finally, RND1 protects cells against camptothecin-induced apoptosis, and hence favors cellular resistance to camptothecin. Together, these findings highlight RND1 as an atypical RHO GTPase early induced by TOP1cc, and show that the TOP1cc-PARP-1-RND1 pathway protects cells against apoptosis induced by camptothecin.
Pkd2l1 is required for mechanoception in cerebrospinal fluid-contacting neurons and maintenance of spine curvature
Authors: Sternberg Jenna R. , Prendergast Andrew E. , Brosse Lucie , Cantaut-Belarif Yasmine , Thouvenin Olivier , Orts-Del’Immagine Adeline , Castillo Laura , Djenoune Lydia , Kurisu Shusaku , McDearmid Jonathan R. , Bardet Pierre-Luc , Boccara Claude , Okamoto Hitoshi , Delmas Patrick , Wyart Claire 
Published: September 2018

AbstractDefects in cerebrospinal fluid (CSF) flow may contribute to idiopathic scoliosis. However, the mechanisms underlying detection of CSF flow in the central canal of the spinal cord are unknown. Here we demonstrate that CSF flows bidirectionally along the antero-posterior axis in the central canal of zebrafish embryos. In the cfap298tm304 mutant, reduction of cilia motility slows transport posteriorly down the central canal and abolishes spontaneous activity of CSF-contacting neurons (CSF-cNs). Loss of the sensory Pkd2l1 channel nearly abolishes CSF-cN calcium activity and single channel opening. Recording from isolated CSF-cNs in vitro, we show that CSF-cNs are mechanosensory and require Pkd2l1 to respond to pressure. Additionally, adult pkd2l1 mutant zebrafish develop an exaggerated spine curvature, reminiscent of kyphosis in humans. These results indicate that CSF-cNs are mechanosensory cells whose Pkd2l1-driven spontaneous activity reflects CSF flow in vivo. Furthermore, Pkd2l1 in CSF-cNs contributes to maintenance of natural curvature of the spine.
Paf1 and Ctr9 subcomplex formation is essential for Paf1 complex assembly and functional regulation
Authors: Xie Ying , Zheng Minying , Chu Xinlei , Chen Yue , Xu Huisha , Wang Jiawei , Zhou Hao , Long Jiafu 
Published: September 2018

AbstractThe evolutionarily conserved multifunctional polymerase-associated factor 1 (Paf1) complex (Paf1C), which is composed of at least five subunits (Paf1, Leo1, Ctr9, Cdc73, and Rtf1), plays vital roles in gene regulation and has connections to development and human diseases. Here, we report two structures of each of the human and yeast Ctr9/Paf1 subcomplexes, which assemble into heterodimers with very similar conformations, revealing an interface between the tetratricopeptide repeat module in Ctr9 and Paf1. The structure of the Ctr9/Paf1 subcomplex may provide mechanistic explanations for disease-associated mutations in human PAF1 and CTR9. Our study reveals that the formation of the Ctr9/Paf1 heterodimer is required for the assembly of yeast Paf1C, and is essential for yeast viability. In addition, disruption of the interaction between Paf1 and Ctr9 greatly affects the level of histone H3 methylation in vivo. Collectively, our results shed light on Paf1C assembly and functional regulation.
Macroscopic helical chirality and self-motion of hierarchical self-assemblies induced by enantiomeric small molecules
Authors: Yang Yang , Liang Jie , Pan Fei , Wang Zhen , Zhang Jianqi , Amin Kamran , Fang Jin , Zou Wenjun , Chen Yuli , Shi Xinghua , Wei Zhixiang 
Published: September 2018

AbstractTransfer of molecular chirality to supramolecular chirality at nanoscale and microscale by chemical self-assembly has been studied intensively for years. However, how such molecular chirality further transfers to the macroscale along the same path remains elusive. Here we reveal how the chirality from molecular level transfers to macroscopic level via self-assembly. We assemble a macrostripe using enantiomeric camphorsulfonic acid (CSA)-doped polyaniline with hierarchical order. The stripe can twist into a single-handed helical ribbon via helical self-motion. A multi-scale chemo-mechanical model is used to elucidate the mechanism underlying its chirality transfer and induction. The molecular origin of this macroscopic helical chirality is verified. Results provide a comprehensive understanding of hierarchical chirality transfer and helical motion in self-assembled materials and even their natural analogues. The stripe exhibits disparate actuation behaviour under stimuli of enantiomeric amines and integrating such chiral perception with helical self-motion may motivate chiral biomimetic studies of smart materials.
Biologically driven DOC release from peatlands during recovery from acidification
Authors: Kang Hojeong , Kwon Min Jung , Kim Sunghyun , Lee Seunghoon , Jones Timothy G. , Johncock Anna C. , Haraguchi Akira , Freeman Chris 
Published: September 2018

AbstractPeatlands store 1/3 of global soil carbon, destabilisation of which contributes much to the recent increase in DOC (dissolved organic carbon) in freshwater ecosystems. One suggested mechanism for the enhanced decomposition of peat and the releases of DOC is recovery from acidification. However, no biological role in the process has yet been identified. Here we report extracellular enzyme activities and microbial composition in peatlands of Korea, the UK, Japan and Indonesia, and find higher pH to promote phenol oxidase activities, greater abundances inActinobacteriaand fungi, and enhanced pore-water DOC concentrations. Our pH manipulation experiments also showed that increase in pH enhanced phenol oxidase activity and DOC production with greater Actinobacterial and fungal abundances. Finally, knockout or addition of phenol oxidase dramatically changed DOC and phenolic production, indicating the central role of phenol oxidase in DOC mobilisation. Our findings provide evidence to support a previously unrecognized biological mechanism through which pH increases activate phenol oxidase, accelerating the release of DOC and phenolics.
Reply to ‘Sigmoidal Acquisition Curves are Good Indicators of Conformist Transmission’
Authors: Acerbi Alberto , van Leeuwen Edwin J. C. , Haun Daniel B. M. , Tennie Claudio 
Published: September 2018

AbstractIn the Smaldino et al. study ‘Sigmoidal Acquisition Curves are Good Indicators of Conformist Transmission’, our original findings regarding the conditional validity of using population-level sigmoidal acquisition curves as means to evidence individual-level conformity are contested. We acknowledge the identification of useful nuances, yet conclude that our original findings remain relevant for the study of conformist learning mechanisms.Replying to: Smaldino, P. E., Aplin, L. M. & Farine, D. R. Sigmoidal Acquisition Curves Are Good Indicators of Conformist Transmission. Sci. Rep. 8, https://doi.org/10.1038/s41598-018-30248-5 (2018).
An effective and concise device for detecting cold allodynia in mice
Authors: Ruan Yonglan , Gu Leying , Yan Jinjin , Guo Jun , Geng Xiao , Shi Hao , Yu Guang , Zhu Chan , Yang Yan , Zhou Yuan , Wang Changming , Tang Zongxiang 
Published: September 2018

AbstractDetection of cold allodynia is a very important aspect in the study of pain behavior. An effective and concise device for detecting cold pain has always been the hope of many researchers. Here, an easily produced and operated cold plate device is presented for the assessment of cold allodynia in mice. The device used to detect cold allodynia has two components: a chamber consists of a cylinder for animal experiment and a cube box around the chamber for holding ice to keep temperature stable. In the testing chamber, a mouse was placed on the circular plexiglass plate steady at 4 °C above ice for five minutes. The tested mouse will lift its paw when exposed to the cold plate. The number of lifts will present animal’s response to the degree of cold stimulation. To evaluate this approach, three commonly used pain models of mice were tested: formalin test, bone cancer pain (BCP), and chronic constriction injury (CCI). As is reported in other literatures, these three pain mice models showed increased sensitivity to cold stimulation. The new device is indeed suitable for detecting cold allodynia behavior in mice. Comparisons with existing devices of detecting cold allodynia, such as the cold plate in the market (UGO, Panlab, Columbus, etc.), the new device has the advantages of low cost, simple operation and easy popularization and can detect cold allodynia behavior of mice very well. This is a very practical and economical device to detect cold allodynia behavior.
Probing Limits of Information Spread with Sequential Seeding
Authors: Jankowski Jarosław , Szymanski Boleslaw K. , Kazienko Przemysław , Michalski Radosław , Bródka Piotr 
Published: September 2018

AbstractWe consider here information spread which propagates with certain probability from nodes just activated to their not yet activated neighbors. Diffusion cascades can be triggered by activation of even a small set of nodes. Such activation is commonly performed in a single stage. A novel approach based on sequential seeding is analyzed here resulting in three fundamental contributions. First, we propose a coordinated execution of randomized choices to enable precise comparison of different algorithms in general. We apply it here when the newly activated nodes at each stage of spreading attempt to activate their neighbors. Then, we present a formal proof that sequential seeding delivers at least as good spread coverage as the single stage seeding does. Moreover, we also show that, under modest assumptions, sequential seeding performs provably better than the single stage seeding using the same number of seeds and node ranking. Finally, we present experimental results comparing single stage and sequential approaches on directed and undirected graphs to the well-known greedy approach to provide the objective measure of the sequential seeding benefits. Surprisingly, applying sequential seeding to a simple degree-based selection leads to higher coverage than achieved by the computationally expensive greedy approach currently considered to be the best heuristic.
Variations of cingulate sulcal organization and link with cognitive performance
Authors: Amiez Céline , Wilson Charles R E , Procyk Emmanuel 
Published: September 2018

AbstractThe sulcal morphology of the human medial frontal cortex has received marked interest because of (1) its remarkable link with the functional organization of this region, and (2) observations that deviations from ‘normal’ sulcal morphological variability correlate with the prevalence of some psychiatric disorders, cognitive abilities, or personality traits. Unfortunately, background studies on environmental or genetic factors influencing the ontogenesis of the sulcal organization in this region are critically lacking. We analysed the sulcal morphological organization in this region in twins and non-twin siblings, as well as in control subjects for a total of 599 subjects from the Human Connectome Project. The data first confirm significant biases in the presence of paracingulate sulci in left vs right hemispheres in the whole population (twin: p < 2.4.10−9; non-twin: p < 2.10−6) demonstrating a clear general laterality in human subjects. Second, measures of similarity between siblings and estimations of heritability suggest significant environmental factors, in particular in-womb environment, and weak additive genetic factors influencing the presence of a paracingulate sulcus. Finally, we found that relationships between sulcal organization and performance in cognitive, motor, and affective tests depend on the twin status (Twins versus Non-twins). These results provide important new insights to the issue of the significance of sulcal organization in the human medial frontal cortex.
Preconditioners for the geometry optimisation and saddle point search of molecular systems
Authors: Mones Letif , Ortner Christoph , Csányi Gábor 
Published: September 2018

AbstractA class of preconditioners is introduced to enhance geometry optimisation and transition state search of molecular systems. We start from the Hessian of molecular mechanical terms, decompose it and retain only its positive definite part to construct a sparse preconditioner matrix. The construction requires only the computation of the gradient of the corresponding molecular mechanical terms that are already available in popular force field software packages. For molecular crystals, the preconditioner can be combined straightforwardly with the exponential preconditioner recently introduced for periodic systems. The efficiency is demonstrated on several systems using empirical, semiempirical and ab initio potential energy surfaces.
Aqueous mounting media increasing tissue translucence improve image quality in Structured Illumination Microscopy of thick biological specimen
Authors: Szczurek Aleksander , Contu Fabio , Hoang Agnieszka , Dobrucki Jurek , Mai Sabine 
Published: September 2018

AbstractStructured Illumination Microscopy (SIM) is a super-resolution microscopy method that has significantly advanced studies of cellular structures. It relies on projection of illumination patterns onto a fluorescently labelled biological sample. The information derived from the sample is then shifted to a detectable band, and in the process of image calculation in Fourier space the resolution is doubled. Refractive index homogeneity along the optical path is crucial to maintain a highly modulated illumination pattern necessary for high-quality SIM. This applies in particular to thick samples consisting of large cells and tissues. Surprisingly, sample mounting media for SIM have not undergone a significant evolution for almost a decade. Through identification and systematic evaluation of a number of non-hazardous, water-soluble chemical components of mounting media, we demonstrate an unprecedented improvement in SIM-image quality. Mounting solutions presented in this research are capable of reducing abundant light scattering which constitutes the limiting factor in 3D-SIM imaging of large Hodgkin’s lymphoma and embryonic stem cells as well as 10 µm tissue sections. Moreover, we demonstrate usefulness of some of the media in single molecule localisation microscopy. The results presented here are of importance for standardisation of 3D-SIM data acquisition pipelines for an expanding community of users.