bluuebunny/crossref_metadata_2025_split huggingface dataset:
Faculty Attitudes Toward Rhinology Fellowship Training: A Survey of Rhinology Fellowship Programs
Authors: Riley Charles A. , Soneru Christian P. , Husain Qasim , Gray Stacey T. , Senior Brent A. , Tabaee Abtin 
Published: October 2018

Background The number of rhinology fellowship programs has grown rapidly over the past decade. To date, no standardization or accreditation process exists, raising the potential for disparate programs. The attitudes of faculty regarding training are important to elucidate the educational experience of rhinology fellowship. Methods An anonymous, web-based survey of rhinology faculty assessed the subjective attitudes toward various domains of fellowship training including surgery, office-based procedures, research, and career development. A 5-point Likert-type scale assessing importance was used (1—not at all important, 5—extremely important). Results A total of 34 faculty (response rate 35.8%) completed the survey. The surgical procedures that received the highest mean importance scores were endoscopic surgery for advanced inflammatory disease (median = 5), cerebrospinal fluid leak closure (5), and extended endoscopic sinus surgery (5). The procedures with the lowest scores were nasal valve repair (2), inferior turbinate surgery (3), and open approaches to the sinuses (4). A wide range of responses was noted for the minimum target number of fellow cases for the surveyed procedures. Higher importance scores were noted for direct attending supervision (5) when compared to fellow autonomy (4, P < .001) or shadowing (3.5, P < .001) in the operating room. Higher scores were noted for career preparation in academic (4) versus private practice (3, P < .001) and providing opportunities for clinical (4) versus basic science research (2, P < .001). The majority of faculty felt that there were too many fellowship positions with respect to the market place for private practice (58.8%), academic jobs (85.3%), and overall societal need (61.8%). Conclusion A range of faculty attitudes with respect to fellowship training was noted in this study. Continued assessment and refinement of the educational experience in rhinology fellowships is necessary.
Two-Year Follow-Up and Remodeling Kinetics of ChonDux Hydrogel for Full-Thickness Cartilage Defect Repair in the Knee
Authors: Wolf Matthew T. , Zhang Hong , Sharma Blanka , Marcus Norman A. , Pietzner Uwe , Fickert Stefan , Lueth Achim , Albers G. H. Robert , Elisseeff Jennifer H. 
Published: October 2018

Objective To determine performance and repair kinetics of the ChonDux hydrogel scaffold for treating focal articular cartilage defects in the knee over 24 months. Design This assessor-blinded trial evaluates ChonDux hydrogel scaffold implantation in combination with microfracture in 18 patients across 6 sites. Male and female patients 18 to 65 years of age with full-thickness femoral condyle defects 2 to 4 cm2 in area were enrolled. Eligible patients received ChonDux treatment followed by rehabilitation. Defect volume fill was evaluated after 3, 6 (primary outcome), 12, 18, and 24 months by assessor blinded magnetic resonance imaging (MRI) analysis. Secondary outcomes were T2-weighted MRI relaxation time and patient surveys via visual analogue scale (VAS) pain and International Knee Documentation Committee (IKDC) knee function scoring. Results ChonDux maintained durable tissue restoration over 24 months with final defect percent fill of 94.2% ± 16.3% and no significant loss of fill volume at any time points. Tissues treated with ChonDux maintained T2 relaxation times similar to uninjured cartilage between 12 and 24 months. VAS pain scoring decreased between 1 and 6 weeks, and IKDC knee function scores improved by approximately 30.1 with ChonDux over 24 months. Conclusion ChonDux treatment is a safe adjunct to microfracture therapy and promotes stable restoration of full thickness articular cartilage defects for at least 24 months.
Preventing clinically important deterioration with single-inhaler triple therapy in COPD
Authors: Naya Ian , Compton Chris , Ismaila Afisi S. , Birk Ruby , Brealey Noushin , Tabberer Maggie , Zhu Chang-Qing , Lipson David A. , Criner Gerard 
Published: October 2018

Clinically important deterioration (CID) is a novel composite end-point (lung function, health status, exacerbations) for assessing disease stability in patients with chronic obstructive pulmonary disease (COPD).We prospectively analysed CID in the FULFIL study. FULFIL (ClinicalTrials.govNCT02345161; randomised, double-blind, double-dummy, multicentre study) compared 24 weeks of once daily, single-inhaler fluticasone furoate/umeclidinium/vilanterol (FF/UMEC/VI) 100/62.5/25 µg with twice daily budesonide/formoterol (BUD/FOR) 400/12 μg in patients aged ≥40 years with symptomatic advanced COPD (Global Initiative for Chronic Obstructive Lung Disease group D). A subset of patients received study treatment for up to 52 weeks. Time to first CID event was assessed over 24 and 52 weeks using two approaches for the health status component: St George's Respiratory Questionnaire and COPD assessment test. FF/UMEC/VI significantly reduced the risk of a first CID event by 47–52%versusBUD/FOR in the 24- and 52-week populations using both CID definitions (p<0.001).The median time to first CID event was ≥169 days and ≤31 days with FF/UMEC/VI and BUD/FOR, respectively. Only stable patients with no CID at 24 weeks demonstrated sustained clinically important improvements in lung function and health status at 52 weeksversusthose who had experienced CID.Once daily, single-inhaler FF/UMEC/VI significantly reduced the risk of CIDversustwice daily BUD/FOR with a five-fold longer period without deterioration.
Cancer-Related Cognitive Outcomes Among Older Breast Cancer Survivors in the Thinking and Living With Cancer Study
Authors: Mandelblatt Jeanne S. , Small Brent J. , Luta Gheorghe , Hurria Arti , Jim Heather , McDonald Brenna C. , Graham Deena , Zhou Xingtao , Clapp Jonathan , Zhai Wanting , Breen Elizabeth , Carroll Judith E. , Denduluri Neelima , Dilawari Asma , Extermann Martine , Isaacs Claudine , Jacobsen Paul B. , Kobayashi Lindsay C. , Holohan Nudelman Kelly , Root James , Stern Robert A. , Tometich Danielle , Turner Raymond , VanMeter John W. , Saykin Andrew J. , Ahles Tim 
Published: October 2018

Purpose To determine treatment and aging-related effects on longitudinal cognitive function in older breast cancer survivors. Methods Newly diagnosed nonmetastatic breast cancer survivors (n = 344) and matched controls without cancer (n = 347) 60 years of age and older without dementia or neurologic disease were recruited between August 2010 and December 2015. Data collection occurred during presystemic treatment/control enrollment and at 12 and 24 months through biospecimens; surveys; self-reported Functional Assessment of Cancer Therapy-Cognitive Function; and neuropsychological tests that measured attention, processing speed, and executive function (APE) and learning and memory (LM). Linear mixed-effects models tested two-way interactions of treatment group (control, chemotherapy with or without hormonal therapy, and hormonal therapy) and time and explored three-way interactions of ApoE (ε4+ v not) by group by time; covariates included baseline age, frailty, race, and cognitive reserve. Results Survivors and controls were 60 to 98 years of age, were well educated, and had similar baseline cognitive scores. Treatment was related to longitudinal cognition scores, with survivors who received chemotherapy having increasingly worse APE scores ( P = .05) and those initiating hormonal therapy having lower LM scores at 12 months ( P = .03) than other groups. These group-by-time differences varied by ApoE genotype, where only ε4+ survivors receiving hormone therapy had short-term decreases in adjusted LM scores (three-way interaction P = .03). For APE, the three-way interaction was not significant ( P = .14), but scores were significantly lower for ε4+ survivors exposed to chemotherapy (−0.40; 95% CI, −0.79 to −0.01) at 24 months than ε4+ controls (0.01; 95% CI, 0.16 to 0.18; P < .05). Increasing age was associated with lower baseline scores on all cognitive measures ( P < .001); frailty was associated with baseline APE and self-reported decline ( P < .001). Conclusion Breast cancer systemic treatment and aging-related phenotypes and genotypes are associated with longitudinal decreases in cognitive function scores in older survivors. These data could inform treatment decision making and survivorship care planning.
Black Hair Haptics
Authors: Morrison Amani 
Published: October 2018

Abstract
In the United States, black hair—that is, the hair of African-descended peoples—has a long and fraught political, economic, and social history that informs its contemporary reception: at the interstices of self-making, aesthetic expression, and respectability politics, black hair has been both overdetermined and underexplored as a site of intellectual inquiry. This essay aims to offer a critical examination of natural black hair as a central site of interpersonal negotiation for black women in the United States. Drawing on performance studies, cultural studies, and black feminist studies, I offer black hair haptics as an analytic for the racialized and gendered dimensions of quotidian public interpersonal engagement with black hair as an extension of the black body. I argue that black hair is a unique site of analysis for transgressions of socially appropriate interpersonal interaction.
Raising the status of software in research: A survey-based evaluation of the Software Sustainability Institute Fellowship Programme
Authors: Sufi Shoaib , Jay Caroline 
Published: October 2018

Background: This paper reports the results of an evaluation of the Software Sustainability Institute’s Fellowship Programme, which focused on identifying and categorising the benefits that the fellowship has afforded its recipients, via a series of open questions. Methods: The evaluation took the form of a survey open to people awarded Fellowships between 2012 and 2016, which asked people to report the effect that the programme had had on them, their institutions, their research domains and their careers. Results: The results show that the Fellowship plays a wide-ranging role in supporting communities of best practice and skills transfer, and that a significant benefit is the way it has raised the profile of software in research, and those people who develop and advocate for it. Conclusions: The evaluation of the programme has shown the need to support research software in situ and credit the engineers and researchers who are working in this important area that supports reproducibility, reuse and the integrity of research investments.
QUALIDADE DE SEMENTES DE AMENDOIM PRODUZIDAS EM PALMEIRAS DE GOIÁS
Authors: De Camargo José Neto Cassiano , Santana Eliete Souza , Cantareli Felipe Kennedy Alves , França Edgar Estevam 
Published: September 2018

Objetivou com o presente trabalho avaliar a qualidade fisiológica de sementes de três cultivares de amendoim produzidas no campo experimental da UEG – Campus Palmeiras de Goiás. Utilizou-se o delineamento inteiramente casualizado, sendo os tratamentos estabelecidos da seguinte forma: T1 – Runner 886; T2 – IAC 505; T3 – IAC 503. Para avaliar a qualidade fisiológica das sementes foi determinado a massa de mil sementes, realizado teste de germinação, com primeira e segunda contagem, além dos valores de matéria verde e seca de plântulas. Na safra 2016/2017 o Brasil alcançou produção total de 456,7 mil toneladas, mostrando a relevância social da cultura em questão. O delineamento experimental empregado foi o de blocos inteiramente casualizados e os dados das diferentes cultivares foram analisados estatisticamente pelo teste F, e as médias foram comparadas pelo teste de Tukey, a 5% de probabilidade, empregando-se o software SISVAR. O resultado apresentado pelos testes foi de que nas condições recomendadas para este experimento, as cultivares utilizadas, exibiram basicamente as mesmas características em relação à qualidade das sementes de amendoim. Fora na primeira contagem do teste de germinação, onde se observou diferença estatística entre as variedades utilizadas. Reforçando a necessidade de concretização de mais experimentos, para que seja possível afirmar com menor probabilidade de erro qual a melhor cultivar para região em questão.
QUALIDADE FÍSICO-QUÍMICA E MICROBIOLÓGICA DO QUEIJO MUÇARELA FATIADO
Authors: Reges Juliana Teodora de Assis , Farias Andressa Matos , Silva Rosana Maria Pereira , Costa Andressa Cristina de Almeida , Cavalcante Letícia Souza 
Published: September 2018

O queijo muçarela é um produto de elevado consumo, porém muito suscetível à contaminação microbiológica esta contamina-ção pode trazer prejuízos à saúde humana. Este trabalho teve como objetivo avaliar a qualidade microbiológica e físico-química do queijo muçarela fatiado, comercializados no município de Jataí- GO. Foram coletadas em 10 supermercados, 10 amostras de queijo muçarela fatiados de diferentes em cada estabelecimento, no período de agosto a novembro de 2016. Para as análises físico-químicas, observou-se a temperatura de comercialização, o pH e o teor de gordura. Com relação os resultados da análise físico-química podermos verificar que os resultados de pH, permaneceram entre 5,45 a 6,08, os de gordura total variaram de 26,3 a 31,1%, e a temperatura de comercialização variaram de 13,4 a 25,1°C. Nas análises microbiológicas verificou-se o NMP (Número Mais Provável) de Coliformes fecais, a presença de Salmonella spp e a contagem de UFC (Unidade de Formadora de Colônia) de Staphylococcus spp. Dentre as amostras analisadas, 30% apresentaram resultados positivos para Salmonella spp, 70% para os Staphylococcus spp e 20% para os Coliformes fecais, sugerindo que a contaminação por estas bactérias pode ser decorrente da inadequação da qualidade da matéria-prima, de higiene e armazenamento durante sua fabricação, pois correspondia ao produto fatiado, provavelmente por esses produtos passarem por uma etapa a mais (fatiamento) antes de serem embalados, pode der ocorrido a contaminação. Geralmente os alimentos contaminados por essas bactérias, causam problemas de intoxicação, podendo levar à morte.
PRODUÇÃO DE Pleurotus florida SOB A INFLUÊNCIA DE DIFERENTES SUBSTRATOS DA AMAZÔNIA MERIDIONAL
Authors: Oliveira Reginaldo De , David Grace Queiroz , Da Silva Mariana Pina , Berti Christian Luis Ferreira , Peres Walmor Moya 
Published: September 2018

O aproveitamento dos resíduos gerados pela agricultura na região amazônica se revela uma alternativa promissora, por ser eficiente e economicamente viável para o cultivo do gênero Pleurotus na Amazônia. A bioconversão destes resíduos em um produto de valor agregado (cogumelo comestível) possibilitará a inserção desta atividade no modelo industrial regional, por possibilitar o aproveitamento de resíduo gerado por este setor. O presente trabalho teve por objetivo avaliar a produção e teor de proteína bruta de Pleurotus florida cultivado em substrato a base de milho e capim elefante na região norte do Mato Grosso. Constituído de 160 unidades amostrais dispostas da seguinte forma: 3 tratamentos com 5 repetições contendo 8 unidades cada repetição totalizando quarenta amostras por tratamento. Os tratamentos foram capim elefante puro (CAP), capim elefante adicionado 20% de farelo de arroz (CAA) e silagem de milho puro (SMP). Foram avaliados inoculação micelial, velocidade de desenvolvimento micelial, tempo de emissão de primórdios, tempo de frutificação, nitrogênio total e proteína bruta e massa fresca e seca de cogumelos. O substrato capim elefante suplementado com 20% de farelo de arroz promoveu melhores condições para o fungo e melhor produtividade nas condições experimentais do Norte do Mato Grosso, nos meses de seca (agosto e setembro).
Liver function in children with human immunodeficiency virus infection before and after 6 months of highly active antiretroviral therapy
Authors: Sapulete Eva Jacomina Jemima , Sanjaya Putra I Gusti Ngurah , Kumara Wati Ketut Dewi , Santoso Hendra , Karyana I Putu Gede , Witarini Komang Ayu , Metriani Nesa Ni Nyoman 
Published: October 2018

Background Highly active antiretroviral therapy (HAART) has resulted in dramatic decreases in morbidity and improved survival rate in human immunodeficiency virus (HIV)-infected patients. Although the risk of morbidity has decreased, it has been replaced by other long-term complications, such as hepatotoxicity. Hepatotoxicity is often reflected in biochemical abnormalities of liver function, such as elevated levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), and aspartate aminotransferase-to-platelet ratio index (APRI).
Objective To compare liver function spectrum (AST, ALT, and APRI) in HIV-infected children before and after at least 6 months of HAART.
Methods This observational study (before and after) was conducted in pediatric patients with HIV infection who received HAART for at least 6 months at Sanglah Hospital, Denpasar. Data were collected from medical records.
Results Forty-nine patients were observed in this study. The mean AST, ALT, and APRI levels before HAART were higher than after at least 6 months of HAART. Anti-tuberculosis treatment and fluconazole therapy were not confounding factors for AST, ALT, and APRI.
Conclusion Liver function spectrum enzyme levels of AST, ALT, and APRI are improved after at least 6 months of HAART.
Lung function test in children with left-to-right shunt congenital heart disease
Authors: Kurniawan Carolina , Murni Indah Kartika , Nugroho Sasmito , Noormanto Noormanto , Naning Roni 
Published: October 2018

Background Increased pulmonary blood flow may lead to abnormal lung function in children with left-to-right (L to R) shunt congenital heart disease. This condition has been linked to considerable mortality and morbidity, including reduced lung function.
Objective To assess for lung function abnormality in children with L to R shunt congenital heart disease.
Methods We conducted a cross-sectional study involving children aged 5-18 years and diagnosed with L to R shunt congenital heart disease at Dr. Sardjito Hospital from March to May 2017. Subjects underwent spirometry tests to measure forced expiratory volume-1 (FEV-1), forced vital capacity (FVC), and forced expiratory volume-1 (FEV-1)/forced vital capacity (FVC).
Results Of 61 eligible subjects, 30 (49.2%) children had atrial septal defect (ASD), 25 (41%) children had ventricular septal defect (VSD), and 6 (9.8%) children had patent ductus arteriosus (PDA). Spirometry revealed lung function abnormalities in 37 (60.7%) children. Restrictive lung function was documented in 21/37 children, obstructive lung function in 11/37 children, and mixed pattern of lung function abnormality in 5/37 children. Pulmonary hypertension was found in 21 children. There was no significant difference in lung function among children with and without pulmonary hypertension (P=0.072).
Conclusion Abnormal lung function is prevalent in 60.7% of children with L to R shunt congenital heart disease, of which restrictive lung function is the most common. There was no significant difference in lung function among children with and without pulmonary hypertension.
Hemostatic abnormalities in children with thalassemia major and liver iron overload
Authors: Wahidiyat Pustika Amalia , Iskandar Stephen Diah , Chozie Novie Amelia , Sekarsari Damayanti 
Published: October 2018

Background Thalassemia major (TM) patients are susceptible to liver dysfunction due to iron deposition. Pediatric TM patients often present with bleeding. Blood loss necessitates transfusions, leading to increased iron absorption from the gut.
Objective To study hemostatic abnormalities in children with TM and iron deposition in the liver.
Methods This cross-sectional study involved 190 non-splenectomized children with TM. Liver iron deposition was evaluated using T2* MRI. Prothrombin time (PT), activated partial thromboplastin time (aPTT), and platelet counts were assessed from blood specimens.
Results Most subjects were diagnosed with β-thalassemia and β-thalassemia/HbE. The majority of subjects were on deferiprone (DFP) treatment. Approximately 89.5% of subjects had liver iron overload. Prolongation of PT and aPTT, as well as thrombocytopenia were observed in 60%, 27.9%, and 19.5% of subjects, respectively. Prolonged aPTT and thrombocytopenia were observed three times more frequently in subjects with moderate - severe liver iron overload than in subjects with normal - mild liver iron overload (P=0.04 and 0.001, respectively).
Conclusion Most TM subjects have liver iron overload ranging from mild to severe. Prothrombin time and prolongation, as well as aPTT prolongation, and thrombocytopenia are easily found in TM children. There were significantly more moderate - severe liver iron deposition patients with aPTT prolongation and thrombocytopenia than normal – mild patients with these conditions. Hence, we suggest that pediatric TM patients undergo liver iron deposition evaluations and use iron chelators in an optimal manner, in order to limit the risk of bleeding.
Program Terapi Sensori Integrasi bagi Anak Tunagrahita di Yayasan Miftahul Qulub
Authors: Komariah Fitri 
Published: September 2018

Children with intellectual disability have limitations in some aspects of personal developments. Yayasan Miftahul Qulub Cipondoh helped the children improve their motoric and sensory skills through the use of integrative sensory therapy. This paper aims to answer how successful the program run by Yayasan Miftahul Qulub Cipondoh, Tangerang city, its inhibiting and supportive factors. This is qualitative research using an evaluation study with CIPP (Context Input Process Product) evaluation model. The study found that integrative sensory therapy in Yayasan Miftahul Qulub has helped the children develop their independence on personal aspects, social cognitive, language skills, motor and sensory. In addition to the efforts of the school, the success of its therapy is supported by the involvement of the parents.[Anak tunagrahita memiliki keterbatasan di beberapa aspek yaitu perkembangan personal, sosial kognitif, keterampilan berbahasa, serta motorik dan sensorik. Hal ini dapat diamati melalui ketidakmatangan dalam perilaku sosialnya. Salah satunya terapi sensori integrasi yang dilakukan oleh Yayasan Miftahul Qulub Cipondoh membantu anak meningkatkan keterampilan motorik dan sensoriknya terutama kepada anak tunagrahita dalam bentuk permainan dan kegiatan sehari-hari. Pertanyaan penelitian bagaimana hasil dari terapi sensori integrasi bagi anak tunagrahita di Yayasan Miftahul Qulub Cipondoh Kota Tangerang serta faktor penghambat dan pendukungnya? Metode yang digunakan dalam penelitian ini adalah metode penelitian kualitatif. Jenis penelitian adalah penelitian evaluasi dengan model evaluasi CIPP, dikhususkan pada evaluasi hasil. Hasil penelitian bahwa terapi sensori integrasi di Yayasan Miftahul Qulub yang terlihat memiliki perubahan perkembangan kemandirian anak tunagrahita pada aspek personal, sosial kognitif, keterampilan berbahasa, serta motorik dan sensorik. Kesuksesan terapi ini didukung keadaan lingkungan dan keterlibatan orang tua dalam proses pelaksanaannya.]