bluuebunny/crossref_metadata_2025_split huggingface dataset:
Detecting learning‐by‐exporting effects on firms' productivity distribution by accounting for heterogeneous macrofactors and panel attrition
Authors: Ferrante Maria R. , Freo Marzia 
Published: April 2019

AbstractThis paper aims to verify the presence of the learning‐by‐exporting effect on total factor productivity growth. The study starts, as is typical in this context, by addressing the pre‐entry selection bias at firm level but differs from the literature by focusing on the distribution of the outcome and considering the presence of the different influences of macroeconomic factors on exporters and non‐exporters. Additionally, the paper addresses the panel attrition, a current source of estimation bias in longitudinal studies. The analysis is based on a panel of Italian manufacturing firms in the 1998–2007 period. We design an experiment by aligning and pooling cohorts of firms that allow us to obtain a sufficiently large group of firms entering the international market. Our results show that internationalisation affects firms' productivity and that the effect is heterogeneous over total factor productivity distribution and larger for the firms at the bottom section of the distribution itself. Furthermore, we observe that the learning‐by‐exporting effect may be confounded without (a) considering that domestic and exporter firms may afford heterogeneous demand cycles and (b) managing the dropout of some firms from the panel.
Alar fold resection in 25 horses: Clinical findings and effect on racing performance and airway mechanics (1998‐2013)
Authors: Strand Eric , Össurardóttir Saga , Wettre Kjersti B. , Fjordbakk Cathrine T. 
Published: April 2019

AbstractObjectiveTo report clinical findings and performance in horses in which alar fold collapse (AFC) had been diagnosed and surgically treated and to assess form and degree of respiratory obstruction.Study designRetrospective case series.AnimalsTwenty‐one standardbreds, 2 coldblooded trotter racehorses, 1 thoroughbred, and 1 Icelandic horse.MethodsAlar fold collapse was diagnosed on the basis of continuous abnormal expiratory flutter noise coinciding with filling of the false nostrils during exercise on a high‐speed treadmill that was alleviated by suturing the alar folds (AF) temporarily in a dorsal position. In 5 cases, nasopharyngeal airway pressures were assessed. Performance after complete, bilateral AF resection was assessed by reviewing career race records and by owner or trainer telephone interviews.ResultsHorses presented because of poor performance, abnormal respiratory noise, or both. Additional dynamic disorders were identified in 12 of 21 standardbreds (intermittent dorsal displacement of the soft palate: n = 10; collapse of the roof of the nasopharynx: n = 2). Expiratory nasopharyngeal pressures seemed elevated in horses with AFC (range, +10.8 to +21.8 cm H2O) compared with normal reference values. Dorsal fixation as well as complete surgical resection of the AF improved expiratory nasopharyngeal pressures to reported normal levels. At a mean of 68 months (range, 7‐121) follow‐up, 20 of 25 horses had competed after surgery, and 13 of 17 of the harness racehorses had established or improved their kilometer racing time marks.ConclusionAlar fold collapse caused mild to moderate expiratory obstruction and may have contributed to secondary nasopharyngeal collapse in this population.Clinical significanceComplete surgical resection seems effective for treating AFC. Nasopharyngeal pressure measurement is a potential tool for confirming the diagnosis of AFC.
IN VITRO PRESERVATION OF RODENT TUBER (TYPHONIUM FLAGELLIFORME LODD.) PEKALONGAN ACCESSION WITH PACLOBUTRAZOL
Authors: Sianipar Nesti Fronika , Naftalia Naftalia , Purnamaningsih Ragapadmi 
Published: April 2019

Rodent tuber plant (Typhonium flagelliforme Lodd.), as one of the most potent medicinal plants, has to be developed as an active ingredient of degenerative drugs, including cancer drugs. However, this enormous potential must be supported by sustainable cultivation of the plant. The conventional preservation of rodent tuber can be done by planting various accessions in the field, but it will need land availability and intensive plant maintenance. Preservation through in vitro culture is an alternative method that can be used. The aim of this study was to determine the effect of paclobutrazol in suppressing the growth of rodent tuber cultures, and test the ability of culture regeneration after being preserved with paclobutrazol. The media formulation used was Murashige and Skoog (1962) (MS) with the addition of paclobutrazol at concentrations of 4, 5, 6, and 7 mg L-1. The results showed that using paclobutrazol at 5 mg L-1 was the best concentration that can inhibit the elongation of buds, seedling formation, leaf formation, and root elongation until 5 months. Cultures of paclobutrazol treatment at 5 mg L-1 had shoot heights, number of shoots, number of leaves, and root lengths of 0.49, 2.33, 7.23, and 0.3 cm, respectively. Paclobutrazol could inhibit the growth of in vitroculture of rodent tuber and prolong the shelf life of culture up to 5 months. The culture of rodent tuber from paclobutrazol treatment had normal growth and regenerative ability after transfer to the medium regeneration.
New insights into the Precambrian tectonic evolution and continental affinity of the Qilian block: Evidence from geochronology and geochemistry of metasupracrustal rocks in the North Wulan terrane
Authors: Wang Lu , Johnston Stephen T. , Chen Nengsong 
Published: April 2019

AbstractThe Qilian block, one of the Precambrian terranes in the Qinling-Qilian-Kunlun orogenic system, is a critical region for reconstruction of the overall architecture and tectonic evolution of NW China. This investigation of zircon U-Pb and Lu-Hf isotopes and whole-rock geochemistry of a metasupracrustal sequence in the North Wulan terrane provides new insights into the Qilian block. A Statherian–Calymmian unit (ca. 1.67–1.5 Ga), dominated by Al- and Si-rich gneisses, arkosites, quartzites, and amphibolites with minor calc-silicate rocks and marbles, is interpreted to have been deposited during continental rifting. Detrital zircons show two main age populations of 2685–2276 and 2098–1761 Ma with mostly negative εHf(t) values (–14.0 to +3.6). The sources are characterized by mixed felsic to intermediate igneous rocks as well as recycled components and are interpreted as being derived from the Tarim craton because of the age distribution of their detrital zircons. A Stenian–Tonian unit (ca. 1.1–0.9 Ga) consists mainly of felsic gneisses, quartzites, calc-silicate rocks, marbles, metavolcanic rocks, and amphibolites. The metasedimentary rocks yielded detrital zircon ages clustering at ca. 1.64, 1.43, 1.3–1.2, 1.1, and 0.94 Ga with predominantly positive εHf(t) values (–7.1 to +9.7). One metavolcanic rock has an age of ca. 1110 Ma and εHf(t) values of +6.5 to +9.1. The provenance is dominated by local syndepositional arc-related igneous rocks with older detritus possibly from Laurentia, again based on the age distribution of the detrital zircons. The Central Qilian and Hualong terranes show strong affinities with the North Wulan terrane and together constituted a single coherent Qilian block prior to their involvement in the Qilian–North Qaidam orogen. The Qilian block was probably once part of the Tarim craton and had a strong linkage to South Tarim, which drifted from North Tarim during the breakup of Columbia in the early Mesoproterozoic. We suggest that, from the late Mesoproterozoic to early Neoproterozoic, the South Tarim–Qilian formed an active continental margin located close to Laurentia during the assembly of Rodinia. The final collision occurred in the early Neoproterozoic with the formation of a significant continent that included the reunified Tarim-Qilian as well as Qaidam-Kunlun and Qinling terranes, Alxa block, Kyrgyz-Chinese Tianshan, and Yili block.
Prehospital determinants of successful resuscitation after traumatic and non-traumatic out-of-hospital cardiac arrest
Authors: Barnard Ed B G , Sandbach Daniel D , Nicholls Tracy L , Wilson Alastair W , Ercole Ari 
Published: April 2019

BackgroundOut-of-hospital cardiac arrest (OHCA) is prevalent in the UK. Reported survival is lower than in countries with comparable healthcare systems; a better understanding of outcome determinants may identify areas for improvement.MethodsAn analysis of 9109 OHCA attended in East of England between 1 January 2015 and 31 July 2017. Univariate descriptives and multivariable analysis were used to understand the determinants of survival for non-traumatic cardiac arrest (NTCA) and traumatic cardiac arrest (TCA). Two Utstein outcome variables were used: survival to hospital admission and hospital discharge.ResultsThe incidence of OHCA was 55.1 per 100 000 population/year. The overall survival to hospital admission was 27.6% (95% CI 26.7% to 28.6%) and the overall survival to discharge was 7.9% (95% CI 7.3% to 8.5%). Survival to hospital admission and survival to hospital discharge were both greater in the NTCA group compared with the TCA group: 27.9% vs 19.3% p=0.001, and 8.0% vs 3.8% p=0.012 respectively.Determinants of NTCA and TCA survival were different, and varied according to the outcome examined. In NTCA, bystander cardiopulmonary resuscitation (CPR) was associated with survival at discharge but not at admission, and the likelihood of bystander CPR was dependent on geographical socioeconomic status. An air ambulance was associated with increased survival to both hospital admission and discharge in NTCA, but only with survival to admission in TCA.ConclusionNTCA and TCA are clinically distinct entities with different predictors for outcome—future OHCA reports should aim to separate arrest aetiologies. Determinants of survival to hospital admission and discharge differ in a way that likely reflects the determinants of neurological injury. Bystander CPR public engagement may be best focused in more deprived areas.
Building capacity for injury prevention: a process evaluation of a replication of the Cardiff Violence Prevention Programme in the Southeastern USA
Authors: Mercer Kollar Laura M , Sumner Steven A. , Bartholow Brad , Wu Daniel T , Moore Jasmine C , Mays Elizabeth W , Atkins Elizabeth V , Fraser David A , Flood Charles E , Shepherd Jonathan P 
Published: April 2019

ObjectivesViolence is a major public health problem in the USA. In 2016, more than 1.6 million assault-related injuries were treated in US emergency departments (EDs). Unfortunately, information about the magnitude and patterns of violent incidents is often incomplete and underreported to law enforcement (LE). In an effort to identify more complete information on violence for the development of prevention programme, a cross-sectoral Cardiff Violence Prevention Programme (Cardiff Model) partnership was established at a large, urban ED with a level I trauma designation and local metropolitan LE agency in the Atlanta, Georgia metropolitan area. The Cardiff Model is a promising violence prevention approach that promotes combining injury data from hospitals and LE. The objective was to describe the Cardiff Model implementation and collaboration between hospital and LE partners.MethodsThe Cardiff Model was replicated in the USA. A process evaluation was conducted by reviewing project materials, nurse surveys and interviews and ED–LE records.ResultsCardiff Model replication centred around four activities: (1) collaboration between the hospital and LE to form a community safety partnership locally called the US Injury Prevention Partnership; (2) building hospital capacity for data collection; (3) data aggregation and analysis and (4) developing and implementing violence prevention interventions based on the data.ConclusionsThe Cardiff Model can be implemented in the USA for sustainable violent injury data surveillance and sharing. Key components include building a strong ED–LE partnership, communicating with each other and hospital staff, engaging in capacity building and sustainability planning.
Changing pattern of recurrences in patients with early HER2-positive breast cancer receiving neoadjuvant chemotherapy in the era of dual anti-HER2 therapy
Authors: Chiu Joanne W , Leung Roland , Tang Vikki , Cheuk Wai Yin , Lo Jessica , Kwok Gin Wai , Wong Hilda , Suen Dacita , Cheung Polly , Wong Ting Ting , Yau Thomas , Kwong Ava 
Published: April 2019

AbstractBackgroundOver the last 10 years, there has been a major treatment revolution for early human epidermal growth factor receptor 2 (HER2)–positive breast cancer. We aimed to explore the outcome of different neoadjuvant chemotherapy in a tertiary breast cancer centre with early HER2-positive breast cancer as well as factors associated with pathological complete response (pCR) and recurrence-free survival (RFS). The pattern of recurrence was also studied.MethodsThis retrospective study analysed the outcome of neoadjuvant chemotherapy during the period 2005 to 2016 in a tertiary referral centre in Hong Kong. Patients were divided into three groups according to the neoadjuvant chemotherapy they received: chemotherapy only (Chemo), chemotherapy plus trastuzumab (Chemo-H) and chemotherapy plus double anti-HER2 therapy (Chemo-DH).ResultsThere were 226 cases analysed during the study period. The rate of pCR was 5%, 26% and 60% in Chemo, Chemo-H and Chemo-DH groups, respectively (Chemo vs pooled Chemo-H/DH: p&lt;0.0001; Chemo-H vs Chemo-DH: p&lt;0.0001). This was accompanied by a trend of increased rate of breast conservation therapy in Chemo-DH cohort (p=0.046). Use of double anti-HER2 therapy, older age (&gt;50 years) and hormone receptor negativity were associated with more pCR. pCR was associated with better RFS. Among those with recurrence, the proportion of patients with brain as the only site of recurrence increased remarkably with more efficacious anti-HER2 treatment (0% in Chemo, 8% in Chemo-H, 67% in Chemo-DH).ConclusionpCR remains an important predictive factor for improved RFS. In the era of dual anti-HER2 neoadjuvant therapy, brain-only recurrence poses a challenge to disease surveillance and treatment.
New cost-effective pleural procedure training: manikin-based model to increase the confidence and competency in trainee medical officers
Authors: Heraganahally Subash , Mehra Sumit , Veitch Daisy , Sajkov Dimitar , Falhammar Henrik , Morton Sharon 
Published: April 2019

AbstractPurpose of the studyPleural diseases are common in clinical practice. Doctors in training often encounter these patients and are expected to perform diagnostic and therapeutic pleural procedures with confidence and safely. However, pleural procedures can be associated with significant complications, especially when performed by less experienced. Structured training such as use of training manikin and procedural skills workshop may help trainee doctors to achieve competence. However, high costs involved in acquiring simulation technology or attending a workshop may be a hurdle. We hereby describe a training model using a simple manikin developed in our institution and provide an effective way to document skill acquisition and assessment among trainee medical officers.Study designThis was a prospective observational study. The need for training, competence and confidence of trainees in performing pleural procedures was assessed through an online survey. Trainees underwent structured simulation training through a simple manikin developed at our institute. Follow-up survey after the training was then performed to access confidence and competence in performing pleural procedures.ResultsForty-seven trainees responded to an online survey and 91% of those expressed that they would like further training in pleural procedure skills. 81% and 85% of responders, respectively, indicated preferred method of training is either practising on manikin or performing the procedure under supervision. Follow-up survey showed improvement in the confidence and competence.ConclusionOur pleural procedure training manikin model is a reliable, novel and cost-effective method for acquiring competences in pleural procedures.
SupplementalTrichomonas vaginalistesting is required to maintain control following a transition from Pap smear to HPV DNA testing for cervical screening: a mathematical modelling study
Authors: Regan David Gabriel , Hui Ben B , Guy Rebecca J , Donovan Basil , Hocking Jane S , Law Matthew G 
Published: April 2019

ObjectivesUsing mathematical modelling, we have previously shown that the prevalence of infection withTrichomonas vaginalis(TV) is likely to increase in the general population in Australia with the transition from Pap smear-based cervical screening to human papillomavirus (HPV) DNA testing. Here we use the existing model to estimate the level of supplemental testing required to maintain TV control.MethodsA compartmental mathematical model describing the transmission of TV in the general heterosexual population in Australia was used to evaluate the impact of a range of screening scenarios on TV prevalence over time following the transition to HPV DNA testing for cervical screening. Scenarios considered were the inclusion of a TV test with the HPV test and the addition of TV testing to routine chlamydia testing conducted in primary care.ResultsOur modelling suggests that with sufficient coverage, inclusion of TV testing with routine chlamydia screening in general practice, TV prevalence can be reduced over time, but at the current reported coverage will gradually increase following the transition to HPV testing. Inclusion of TV testing with HPV testing in the cervical screening programme is preferable to no supplemental testing but is considerably less effective in controlling TV.ConclusionsThese findings support the inclusion of TV testing with routine chlamydia testing of young people.
Resuscitative endovascular balloon occlusion of the aorta (REBOA): indications: advantages and challenges of implementation in traumatic non-compressible torso hemorrhage
Authors: Bekdache Omar , Paradis Tiffany , Shen Yu Bai He , Elbahrawy Aly , Grushka Jeremy , Deckelbaum Dan , Khwaja Kosar , Fata Paola , Razek Tarek , Beckett Andrew 
Published: April 2019

BackgroundResuscitative endovascular balloon occlusion of the aorta (REBOA) is regaining popularity in the treatment of traumatic non-compressible torso bleeding. Advances in invasive radiology coupled with new damage control measures assisted in the refinement of the technique with promising outcomes. The literature continues to have substantial heterogeneity about REBOA indications, applications, and the challenges confronted when implementing the technique in a level I trauma center. Scoping reviews are excellent platforms to assess the diverse literature of a new technique. It is for the first time that a scoping review is adopted for this topic. Advances in invasive radiology coupled with new damage control measures assisted in the refinement of the technique with promising outcomes. The literature continues to have substantial heterogeneity about REBOA indications, applications, and the challenges confronted when implementing the technique in a level I trauma center. Scoping reviews are excellent platforms to assess the diverse literature of a new technique. It is for the first time that a scoping review is adopted for this topic.MethodsCritical search from MEDLINE, EMBASE, BIOSIS, COCHRANE CENTRAL, PUBMED and SCOPUS were conducted from the earliest available dates until March 2018. Evidence-based articles, as well as gray literature at large, were analyzed regardless of the quality of articles.ResultsWe identified 1176 articles related to the topic from all available database sources and 57 reviews from the gray literature search. The final review yielded 105 articles. Quantitative and qualitative variables included patient demographics, study design, study objectives, methods of data collection, indications, REBOA protocol used, time to deployment, zone of deployment, occlusion time, complications, outcome, and the level of expertise at the concerned trauma center.ConclusionGrowing levels of evidence support the use of REBOA in selected indications. Our data analysis showed an advantage for its use in terms of morbidities and physiologic derangement in comparison to other resuscitation measures. Current challenges remain in the selective application, implementation, competency assessment, and credentialing for the use of REBOA in trauma settings. The identification of the proper indication, terms of use, and possible advantage of the prehospital and partial REBOA are topics for further research.Level of evidenceLevel III.
The improvement of thermal conductivity in silica gel composite employing graphene nano-particles
Authors: Lv Jian , Cai Xiaoming , Ye Qianxu , Cai Jinming 
Published: April 2019

Heat conducting gel sheets were fabricated with graphene nano-particles (GNPs) filler which was prepared by ball-milling method. The thermal conductivity of GNPs gel sheets (GNPs-GS) with 10 wt.% reaching 0.38 W/(m⋅K) at [Formula: see text] increased by 90% compared with the pure gel sheets (Pure-GS). The conduction of heat-sink device which was made of GNPs-GS with 10 wt.% is much faster than the one which was made of Pure-GS. FE-SEM images show that the GNPs are layered and uniformly distributed in the matrix, which demonstrated the actual exfoliation of GNPs in the process of ball-milling. This handy and cost-efficient method of ball-milling to exfoliate GNPs and further for fabricating heat conducting gel sheets is a feasible program in industrial production.
Computer Aided Finite Element Simulation of the Developed Driller System for Bone Drilling Process in Orthopedic Surgery
Authors: Gok Kadir , Gok Arif , Kisioglu Yasin 
Published: April 2019

Heat reveals during the bone drilling operations in orthopedic surgery because of friction between bone and surgical drill bit. The heating causes extremely important damages in bone and soft tissues. The heating has a critical threshold and it is known as 47∘C. If bone temperature value exceeds 47∘C, osteonecrosis occurs in bones and soft tissues. Many factors such as surgical drill bit geometry and material, drilling parameters, coolant has important roles for the temperature rise. Many methods are used to decrease the temperature rise. The most effective method among them is to use the coolant internally. Numeric simulations of a new driller system to avoid the overheating during the orthopedic operating processes were performed in this study. The numerical simulation with/without coolant was also performed using the finite element based software. Computer aided simulation studies were used to measure the bone temperatures occurred during the bone drilling processes. The outcomes from the simulations were compared with the experimental results. A good temperature level agreement between the experimental results and FEA simulations was found during the bone drilling process.