bluuebunny/crossref_metadata_2025_split huggingface dataset:
Discipline-specific open access publishing practices and barriers to change: an evidence-based review
Authors: Severin Anna , Egger Matthias , Eve Martin Paul , Hürlimann Daniel 
Published: December 2018

Background: Many of the discussions surrounding Open Access (OA) revolve around how it affects publishing practices across different academic disciplines. It was a long-held view that it would be only a matter of time for all disciplines to fully and relatively homogeneously implement OA. Recent large-scale bibliometric studies show however that the uptake of OA differs substantially across disciplines. This study investigates the underlying mechanisms that cause disciplines to vary in their OA publishing practices. We aimed to answer two questions: First, how do different disciplines adopt and shape OA publishing practices? Second, what discipline-specific barriers to and potentials for OA can be identified? Methods: In a first step, we identified and synthesized relevant bibliometric studies that assessed OA prevalence and publishing patterns across disciplines. In a second step, and adopting a social shaping of technology perspective, we studied evidence on the socio-technical forces that shape OA publishing practices. We examined a variety of data sources, including, but not limited to, publisher policies and guidelines, OA mandates and policies and author surveys. Results: Over the last three decades, scholarly publishing has experienced a shift from “closed” access to OA as the proportion of scholarly literature that is openly accessible has increased continuously. The shift towards OA is however uneven across disciplines in two respects: first, the growth of OA has been uneven across disciplines, which manifests itself in varying OA prevalence levels. Second, disciplines use different OA publishing channels to make research outputs OA. Conclusions: We conclude that historically grown publishing practices differ in terms of their compatibility with OA, which is the reason why OA can be assumed to be a natural continuation of publishing cultures in some disciplines, whereas in other disciplines, the implementation of OA faces major barriers and would require a change of research culture.
Plasma DNA Analysis in Prostate Cancer: Opportunities for Improving Clinical Management
Authors: Wu Anjui , Attard Gerhardt 
Published: December 2018

Abstract

BACKGROUND
Molecular characterization of tumors could be important for clinical management. Plasma DNA obtained noninvasively as a liquid biopsy could be widely applicable for clinical implementation in biomarker-based treatment strategies.

CONTENT
Prostate cancer is a disease with variable clinical outcomes and molecular features and therefore presents multiple opportunities for biomarker-based treatment optimization. Tissue analysis may not be representative of the lethal clone in localized disease or of intrapatient, intermetastases heterogeneity; fresh tissue is often challenging to obtain by biopsy of metastasis, whereas archival samples may not represent current disease and may be of insufficient quality. Plasma DNA is of variable tumor-to-normal fraction that requires accurate estimation using sensitively measured genomic events. In plasma with sufficient tumor content, the spectrum of genomic aberrations closely resembles tissue and could be used to molecularly characterize patients in real time. In this review we discuss the opportunities for improving clinical management by using plasma DNA analysis in different clinical scenarios across the disease spectrum, from detection of prostate cancer and disease relapse to treatment response prediction, response assessment, and interrogation of treatment resistance in metastatic prostate cancer. Combinational strategies may incorporate other modalities, including circulating tumor cells, circulating microRNA, and extracellular vesicles analysis, which could help to achieve more accurate characterization.

SUMMARY
There are many opportunities for plasma DNA analyses to change clinical management. However, there are challenges that need to be addressed to clinically implement a test, including the development of accurate, fit for purpose, and technically reproducible assay, followed by prospective validation in a large cohort of patients.
Myanmar's earliest Maritime Silk Road port-settlements revealed
Authors: Bellina Bérénice , Win Maung Sun , Htwe Kalayar Myat Myat , Thu Htet Myat , Castillo Cristina , Colonna Camille , Dussubieux Laure , Favereau Aude , Miyama Emiri , Pradier Baptiste , Pryce Thomas Oliver , Srikanlaya Sachipan , Trivière Elisabeth 
Published: December 2018

Abstract
Tai Chi Combined With Resistance Training for Adults Aged 50 Years and Older: A Systematic Review
Authors: Qi Meiling , Moyle Wendy , Jones Cindy , Weeks Benjamin 
Published: December 2018

Background and Purpose:
Despite Tai Chi and resistance training being recommended as suitable exercise for older adults, there are no systematic reviews synthesizing the effectiveness of a combination of Tai Chi and resistance training on health promotion of older adults. This study aimed to review the existing literature regarding the effect of Tai Chi and resistance training on physical health, mental health, pain, health-related quality of life, and age-related impairment in adults aged 50 years and older.

Methods:
A systematic review was conducted to report the health outcomes of Tai Chi combined with resistance training research in adults aged 50 years and older. Articles were identified by searching PubMed, Scopus, Web of Science, CINAHL, MEDLINE, Physiotherapy Evidence Database (PEDro), and the Cochrane library using search terms representing “Tai Chi” and “resistance” and “older adults.” Quantitative experimental studies with participants aged 50 years and older, where one of the interventions was Tai Chi and resistance training, were included.

Results and Discussion:
The literature search yielded 648 articles from which 7 met the inclusion criteria. Collectively, the studies involved 703 participants aged 50 years and older, including healthy older adults, older adults with history of falls, postmenopausal women, and people diagnosed with end-stage hip osteoarthritis. Studies included different Tai Chi forms in combination with various types of resistance training. Training sessions were 2 to 7.5 h/wk and lasted between 12 weeks and 12 months. After long-term Tai Chi and resistance training, the participants showed significant improvement in upper and lower extremity muscle strength, aerobic endurance, balance, and mobility. However, 1 study failed to show improvement in Functional Movement Screening compared with traditional Tai Chi and nonexercise groups. No study examined the effects of Tai Chi and resistance training on health-related quality of life, fear of falling, or mental health in adults aged 50 years and older.

Conclusions:
The review supports that Tai Chi in combination with resistance training improves physical function and muscle strength in adults aged 50 years and older.
A clinically functioning gonadotroph adenoma presenting with abdominal pain, ovarian hyperstimulation and fibromatosis
Authors: Broughton Chloe , Mears Jane , Williams Adam , Lonnen Kathryn 
Published: December 2018

Summary
Pituitary adenomas can be classified as functioning or non-functioning adenomas. Approximately 64% of clinically non-functioning pituitary adenomas are found to be gonadotroph adenomas on immunohistochemistry. There are reported cases of gonadotroph adenomas causing clinical symptoms, but this is unusual. We present the case of a 36-year-old female with abdominal pain. Multiple large ovarian cysts were identified on ultrasound requiring bilateral cystectomy. Despite this, the cysts recurred resulting in further abdominal pain, ovarian torsion and right oophorectomy and salpingectomy. On her 3rd admission with abdominal pain, she was found to have a rectus sheath mass which was resected and histologically confirmed to be fibromatosis. Endocrine investigations revealed elevated oestradiol, follicle-stimulating hormone (FSH) at the upper limit of the normal range and a suppressed luteinising hormone (LH). Prolactin was mildly elevated. A diagnosis of an FSH-secreting pituitary adenoma was considered and a pituitary MRI revealed a 1.5 cm macroadenoma. She underwent transphenoidal surgery which led to resolution of her symptoms and normalisation of her biochemistry. Subsequent pelvic ultrasound showed normal ovarian follicular development. Clinically functioning gonadotroph adenomas are rare, but should be considered in women presenting with menstrual irregularities, large or recurrent ovarian cysts, ovarian hyperstimulation syndrome and fibromatosis. Transphenoidal surgery is the first-line treatment with the aim of achieving complete remission.

Learning points:

Pituitary gonadotroph adenomas are usually clinically non-functioning, but in rare cases can cause clinical symptoms.

A diagnosis of a functioning gonadotroph adenoma should be considered in women presenting with un-explained ovarian hyperstimulation and/or fibromatosis.

In women with functioning gonadotroph adenomas, the main biochemical finding is elevated oestradiol levels. Serum FSH levels can be normal or mildly elevated. Serum LH levels are usually suppressed.

Transphenoidal surgery is the first-line treatment for patients with functioning gonadotroph adenomas, with the aim of achieving complete remission.
Metformin induces weight loss associated with gut microbiota alteration in non-diabetic obese women: a randomized double-blind clinical trial
Authors: Ejtahed Hanieh-Sadat , Tito Raul Y , Siadat Seyed-Davar , Hasani-Ranjbar Shirin , Hoseini-Tavassol Zahra , Rymenans Leen , Verbeke Kristin , Soroush Ahmad-Reza , Raes Jeroen , Larijani Bagher 
Published: December 2018

Objective
The increasing prevalence of obesity over the past few decades constitutes a global health challenge. Pharmacological therapy is recommended to accompany life-style modification for obesity management. Here, we perform a clinical trial to investigate the effects of metformin on anthropometric indices and gut microbiota composition in non-diabetic, treatment-naive obese women with a low-calorie diet (LCD).

Design
Randomized double-blind parallel-group clinical trial

Methods
Forty-six obese women were randomly assigned to the metformin (500 mg/tab) or placebo groups using computer-generated random numbers. Subjects in both groups took two tablets per day for 2 months. Anthropometric measurements and collection of blood and fecal samples were done at the baseline and at the end of the trial. Gut microbiota composition was assessed using 16S rRNA amplicon sequencing.

Results
Twenty-four and twenty-two subjects were included in the metformin + LCD and placebo + LCD groups, respectively; at the end of trial, 20 and 16 subjects were analyzed. The metformin + LCD and placebo + LCD caused a 4.5 and 2.6% decrease in BMI from the baseline values, respectively (P < 0.01). Insulin concentration decreased in the metformin + LCD group (P = 0.046). The overall fecal microbiota composition and diversity were unaffected in the metformin + LCD group. However, a significant specific increase in Escherichia/Shigella abundance was observed after metformin + LCD intervention (P = 0.026). Fecal acetate concentration, but not producers, was significantly higher in the placebo + LCD group, adjusted for baseline values and BMI (P = 0.002).

Conclusions
Despite the weight reduction after metformin intake, the overall fecal microbiota composition remained largely unchanged in obese women, with exception of changes in specific proteobacterial groups.
Desarrollo de la competencia global en la formación del maestro. El caso de la asignatura Practicum
Authors: Cornejo Sosa María José , Gómez-Jarabo Inmaculada 
Published: December 2018

El hecho de que las aulas de infantil y primaria sean cada vez más multiculturales, hace necesario que los futuros maestros posean un grado de dominio alto en competencia intercultural. Así lo señala la OCDE a través de la evaluación de PISA al incluir para este 2018 la evaluación de la competencia global definida como “capacidad de analizar asuntos globales e interculturales, valorar distintas perspectivas desde el respeto por los derechos humanos, para interrelacionarse con personas de diferentes culturas emprender acciones por el bien común y por el desarrollo sostenible” (OCDE, 2016, p. 4). Sin embargo, si observamos los programas de los actuales Grados, la presencia de asignaturas y orientaciones que faciliten el conocimiento y comprensión de asuntos globales, las destrezas de pensamiento crítico y las actitudes de apertura y empatía hacia puntos de vista diferentes al propio, no es suficiente. En este sentido, el objetivo de este artículo es doble. En primer lugar, llamar la atención sobre la escasa preparación del estudiante universitario, en concreto de los Grados de Educación Infantil y Primaria, como responsable de desarrollar esta competencia en las siguientes generaciones y, en segundo lugar, proponer la asignatura de Practicum como medio propicio para desarrollar una pedagogía que familiarice a los chicos con diferentes contextos culturales.
Los Institutos Escuela en Catalunya: recuperando la mejor tradición pedagógica de la república
Authors: Martínez Muñoz Màrius , Pinya Salomó Carmina 
Published: December 2018

El artículo ofrece la síntesis de un estudio desarrollado en 2011 en 12 de los 18 Institutos Escuela (IE) que funcionaban en Catalunya en el marco de la Ley de Educación de Catalunya. El estudio, financiado por el Consell Superior d'Avaluació del Sistema Educatiu y el Instituto de Ciencias de la Educación de la UAB, abordó la visión que de estas instituciones tenían los directivos de los centros, una muestra del profesorado, de los tutores y tutoras y de las famílias, en los ámbitos organizativo, curricular, de orientación y de relación con el entorno. También se estudiaron dinámicas de coordinación entre centros de educación infantil y primaria y centros de secundaria en los mismos territorios con el fin de comprobar y contrastar otras dinámicas de coordinación en los mismos ámbitos en instituciones separadas. Los resultados mostraron una visión muy positiva por parte de todos los colectivos vinculados a los IE y también permitieron identificar 50 prácticas de referencia en la coordinación de las dos etapas en los planos citados, que se reseñan también en el artículo. El artículo termina con diez conclusiones que, en opinión de los autores, siguen perfectamente vigentes en la actualidad.
The CAT-262 C>T, MnSOD Ala16Val, GPX1 Pro198Leu Polymorphisms Related to Oxidative Stress and the Presence of Gastric Lesions
Authors: Negovan Anca , Iancu Mihaela , Tripon Florin , Crauciuc Andrei , Mocan Simona , Bănescu Claudia 
Published: December 2018

Background & Aims: The increased oxidative stress plays an important role in gastro-duodenal ulcers and gastric cancer occurrence. We investigated the association between the genetic polymorphisms of genes encoding the antioxidative enzymes CAT, GPX and SOD and the occurrence of gastric lesions, considering also the environmental risk factors such as H. pylori infection, drug exposure, smoking and alcohol consumption.Methods: We included 373 patients who underwent endoscopy for symptoms, anemia or bleeding investigation. A complete set of demographical, clinical and pathological data was recorded. All patients were successfully genotyped.Results: In the multivariate logistic regression model, the patients having Pro/Pro genotype of GPX1 gene polymorphism had more severe gastric lesions as compared with patients with the Leu/Pro or Leu/Leu genotype (OR= 1.89, 95%CI: 0.99-3.57, p=0.051). The GPX1 Pro198Leu and the MnSOD Ala16Val gene polymorphism could be independent risk factors for reactive gastropathy changes, as shown by their association very close tostatistical significance (p=0.059 and p=0.054, respectively). Consumption of anticoagulants was a significant independent predictor (p=0.023, OR:0.43 95%CI:0.21-0.89) for the absence of active gastritis, while low-dose aspirin consumption was a risk factor for active gastritis in biopsy samples (p=0.025, OR:1.71, 95%CI:1.07-2.74).Conclusion: The variant genotype of GPX1Pro198Leu was associated with an increased risk for reactive gastropathy changes in gastric biopsies and with less severe endoscopic lesions, while MnSODAla16Val variant genotype (Val/Val or Val/Ala) seems to be related to the reactive gastropathy. However, none of them were associated with inflammatory or premalignant gastric lesions.
Diagnosis and Treatment of Colonic Diverticular Disease: Position Paper of the Romanian Society of Gastroenterology and Hepatology
Authors: Trifan Anca , Gheorghe Cristian , Sabo Cristina Marica , Diculescu Mircea , Nedelcu Laurențiu , Singeap Ana Maria , Sfarti Cătălin , Gheorghe Liana , Sporea Ioan , Tanțău Marcel , Scripcariu Viorel , Goldiș Adrian , Gheonea Dan , Manuc Mircea , Stanciu Carol , Scarpignato Carmelo , Dumitrașcu Dan L 
Published: December 2018

Background & Aims: Diverticular disease of the colon is a common clinical condition in developed countries, and is associated with significant (direct and indirect) economic burden. The aim of this Position Paper is to provide clinical guidance for appropriate definition, prevalence, risk factors, diagnosis, and treatment of colonic diverticular disease.Methods: A working group of recognized experts established by the Board of the Romanian Society of Gastroenterology and Hepatology (RSGH) screened the literature and the available guidelines on colonic diverticular disease. Statements were formulated based on literature evidence. These statements were discussed within the working group and decision for each of them was taken by consensus.Results: Thirty two statements were elaborated. The grade of recommendation, according to the level of evidence was established for each statement. Short comments with literature support accompany each statement.Conclusion: This Position Paper represents a practical guide for clinicians dealing with patients affected by colonic diverticular disease.
Patient-Reported Experiences with a Relicensed Generic: Thioguanine for the Treatment of Inflammatory Bowel Diseases
Authors: Simsek Melek , Markus-de Kwaadsteniet Tineke M.L. , Van der Horst Danielle , Mulder Chris J.J. , De Boer Nanne K.H. 
Published: December 2018

Background & Aim: Patient-reported outcomes and experiences are indicative of the impact and the quality of care. Thioguanine, a generic drug initially developed for leukemia, has been explored and relicensed as a certified treatment for patients with inflammatory bowel diseases (IBD). The patients‘ perception of this treatment has not been evaluated before. In this study, we aimed to assess self-reported experiences with thioguanine for IBD.Methods: Questionnaires were sent out to members of the Dutch National Crohn‘s and Colitis patient organization. The Treatment Satisfaction with Medicines Questionnaire (SATMED-Q) was used to address questions regarding the satisfaction and impact of thioguanine therapy on the disease and their daily life. Furthermore, data on demographics, disease and (historical) treatment characteristics were collected. Openended questions were used for additional comments to the questionnaire.Results: A total of 173 organization members (73% female) reported to be previous or current users of thioguanine. A total of 74% were satisfied with the effectiveness of thioguanine, whereas 5% were not. Eighty percent of the respondents were satisfied with the quality of care. A good or excellent impact on daily life was reported by 54%. A neutral or bad impact on daily life was reported by 40% and 6%, respectively. Improvement of disease activity was reported by 58%. This remained stable or worsened in 39% and 3%, respectively.Conclusion: In this self-report survey, among thioguanine treated patients with IBD who had failed with traditional therapies, 80% reported satisfaction with medical care and 74% with the effectiveness of the therapy. In the evaluation of new or rediscovered therapies, patient-reported outcomes and experiences should be considered as a key instrument.
ASPEK PERLINDUNGAN ANAK DALAM PEMBERIAN SANKSI OLEH GURU TERHADAP SISWA
Authors: Gandara Agus 
Published: December 2018

Berdasarkan hasil penelitian yang dilakukan oleh UNICEF (2006) di beberapa daerah di Indonesia menunjukkan bahwa sekitar 80% kekerasan yang terjadi pada siswa dilakukan oleh guru, padahal guru sebagai orang tua kedua para siswa di sekolah sepatutnya menjadi seseorang yang mampu menciptakan suasana yang nyaman di lingkungan sekolah sebagai tempat yang selama ini dipercaya paling aman dan terbaik untuk anak. Hasil penelitian menunjukan bahwa Undang-Undang Nomor 17 Tahun 2016 Tentang perlindungan Anak secara tegas menyatakan bahwa anak di dalam dan di lingkungan sekolah wajib dilindungi dari tindakan kekerasan yang dilakukan oleh guru, pengelola sekolah atau teman-temannya di dalam sekolah yang bersangkutan, atau lembaga pendidikan lainnya. Undang-Undang tersebutmenyatakan setiap orang yang melakukan kekejaman, kekerasan atau ancaman kekerasan, atau penganiayaan terhadap anak, dipidana dengan pidana penjara dan/atau denda. Demikian pula pemberian sanksi yang dilakukan pendidik terhadap peserta didik di lingkungan pendidikan termasuk kategori tindak kekerasan jika pemberian sanksi tersebut melukai dan atau mencederai anak dan tidak semata-mata fisik, tetapi juga mental dan sosial namun demikian dalam peraturan pemerintah nomor 19 tahun 2017 tentang guru, memberikan kewenangan kepada guru untuk memberikan sanksi kepada siswa yang dianggap melanggar peraturan sekolah. Kata Kunci : Guru, Siswa dan Perlindungan Anak Abstract Based on a survey conducted by UNICEF in 2006 in several regions in Indonesia, found that 80% violence that happened toward students were done by their teachers, where the teacher should be act as students’ second parents at school, who should provide and create a comfortable and secure place for the children. The results showed that the law number 17 Year 2016 on child protection explicitly states that children at school environment must be protected from any acts of violence committed by teachers, school administrators, friends at school, and other educational institution.The constitution states any person who commits cruelty, violence or threats of violence, or child abuse, punished by imprisonment or fines. Similarly if there are sanctions given by educators on learners in an educational environment will be included as category of violence if the sanctions hurt or injure the child not merely physical but also mental and social, but the goverment regulations number 19 of 2017 concerning teacher, provinding authority to teacher to sanction students who are considered violating school regulations. Keyword: Teacher, Students and Child Protection