bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sitagliptin recuperates oxidative stress and inflammatory cytokine expression in ovary of PCOS rats
Authors: Carani Anuradha Venkatraman , Dipti Nanda 
Published: September 2019

Abstract
Introduction: Polycystic ovary syndrome (PCOS) is an endocrine, reproductive and metabolic disorder and a major cause of infertility in women. Testosterone propionate (TP) is used to induce PCOS in rats. High calorie diet causes metabolic changes, oxidative stress and PCOS. Sitagliptin (STG) is an inhibitor of dipeptide peptidase (DPP) 4 enzyme used in the treatment of type 2 diabetes. Objective: The aim of the study is to investigate the effect of high fat, high fructose diet (HFFD) on TP induced PCOS rats and the role of STG on oxidative stress and inflammation in PCOS. Materials and methods: PCOS was induced by administration of TP to normal pellet and HFFD fed rats for 43 days. STG (i.p.) was given for the last 15 days to both groups of rats. Vaginal smear, parameters of oxidative stress, antioxidants and inflammation (TNF-α and IL-6) in ovary were analyzed. Results: Vaginal smear from TP rats consisted of persistent leucocytes, a characteristic of PCOS. All the TP administered rats registered significanty elevated levels of glucose, lipids, oxidative stress and inflammatory markers, and reduced levels of antioxidants compared to CON rats. STG treatment to PCOS rats reduced hyperglycemia and hyperlipidemia, oxidative stress and inflammation and improved estrus cycle. Conclusion: High energy diet aggravated TP-induced changes in oxidative stress and inflammatory cytokines in ovary. STG recuperated the changes induced by TP, suggesting that STG holds potential for PCOS management.
Formulation and Evaluation of Floating and Mucoadhesive Tablets Containing Rosiglitazone
Authors: Arun Jagdish K , Pattanayak Dharmajit , Adepu Ramesh , Hossain C.M , Shrivastava B. , Sura Ramya Sri 
Published: September 2019

In this present study, floating mucoadhesive tablets of Rosiglitazone were formulated to improve the gastric retention time and overall bioavailability. Different mucoadhesive polymers like HPMC K200 M, Na CMC, Carbopol 974P, Karaya gum, Chitosan and Xanthan gum were selected to formulate the tablets. Various formulations were prepared by using these polymers in different concentration. The pre-compression blend of Rosiglitazone mucoadhesive tablets were characterized with respect to angle of repose, bulk density, tapped density, carr’s index and hausner’s ratio and all the results indicated that the blend was having good flow property and hence better compression properties. The swelling studies were performed for the formulations and the results depicted that all the formulations have a good swelling index. The drug release studies depicted that the formulations release the drug in first order. So based on the results, formulation RF13 was found to be an optimized formulation.
Keywords: Mucoadhesive tablets, Rosiglitazone, Bioadhesive polymers.
Cytoprotection Alternatives for Cancer Treatment: In-vitro Evaluation of Alpinia Zerumbet as a Radioprotective Agent
Authors: Bhardwaj Shukla Ritwiz , Ganesh N , Kori M.L. 
Published: September 2019

Cancer radiotherapy and modern synthetic medicine are critical for the treatment of cancer patients, but on the other hand they may have tremendous harmful side effect from the point of view of a weakened immune system. The focus of current research efforts in the industry and academia is not only to find affordable treatment methodologies but also to discover sources that mitigates or prevents the negative impact of these treatments on the patient’s immune system. This review will provide details of optimal methodology involving Invitro application of techniques such as phytochemical analysis, thin layer chromatography, cytogenetic analysis that were adopted to assess the efficacy of Alpinia Zerumbet extracts as a radioprotector. These methodologies provide a holistic evaluation technique for assessing any potential cytoprotective agent, especially if it’s from the herbal domain. As a case study, analytical and inferential results summary of the research conducted to assess radioprotective property of Alpinia Zerumbet, a herbal and readily available derivative, will be presented. The key findings from the research indicate that the Alpinia Zerumbet extract has potential to be an effective radioprotector, with minimal side effects as compared to synthetic chemical cytoprotective agents.
Keywords: Radioprotection; cancer; herbal; Alpinia Zerumbet
Microballoons: A Gastro Retentive Drug Delivery System
Authors: Srivastava Ankita , Shukla Ruchi , Sharma Kusum , Jain Hitesh , Meshram D. B. 
Published: September 2019

Oral route is most preferable and widely used route for the administration of drug. Microballoons becomes novel technology in pharmaceutical field in the floating drug delivery for achieving the gastric retention. Microballoons are also called as hollowspheres which are porous smooth in nature and thus show good floating properties in gastric fluid. Microballoons release the drug in controlled manner at the targeted site. Microballoons are spherical empty vesicles without core and that can remain buoyant in gastric region for prolong period of time without irritation in gastrointestinal tract. Multiparticulate particles having a low density system that can efficiently prolong the gastric retention time of the drugs, thus enhanced bioavailability and thus improve the dosing frequency. These are less soluble at higher pH environment. As microballoons delivery systems provide longer retention in gastric pH and enhance the solubility of drugs that are less soluble in high pH environment. The formation of cavity inside the microballoons depend on the preparation, temperature and the surface smoothness determine the floatability and the release rate of microballoons.
Keywords: Microballoons, Gastro retentive drug delivery system, Hollowspheres, Controlled release
A Review on Glycyrrhiza glabra L. (Aṣl al-Sūs) with Unani Perspective and Modern Pharmacology
Authors: Fatima Gulnaz , Jabeen Arzeena , Siddiqui Shahid A. , Khalid Mohammad 
Published: September 2019

Traditional Unani (Greco-Arab) medicine is among the most ancient therapies founded by the father of Western medicine, the Hippocrates. Presently, most of the population worldwide depend on herbal medicines for some aspect of their primary health care needs. Treatment with medicinal plants is appraised very safely as there are no or minimal side effects. The promising fact is that herbal treatment can be used irrespective of any age group. Most of the pharmaceutical companies are currently conducting extensive research on plant materials assemble from the rain forests and other places for their potential medicinal value. Glycyrrhiza glabra L. (Leguminosae/Fabaceae) is best known for its use in making licorice-flavored confectionery. In Unani medicine, it is commonly known as Aṣl al-Sūs. It is a plant of remote origin. Aṣl al-Sūs extracts and its principle element “glycyrrhizin” have widely been used in foods, tobacco and for medicinal purposes in herbal and traditional medicines as well. It possesses multiple pharmacological and medicinal activities such as anti-ulcer, anti-inflammatory, anti-viral, and hepatoprotective actions. This review attempts to compile the data regarding its ethnobotanical actions and medicinal uses in Unani medicine along with its phyto-pharmacological descriptions.
Keywords: Herbal medicine, Aṣl al-Sūs., Glycyrrhiza glabra L.
Formulation and Evaluation of Floating Matrix Tablets of Sacubitril and Valsartan
Authors: Pathak Sudhakar , Pandey Harish , Shah Sunil Kumar 
Published: September 2019

Floating Drug Delivery Systems (FDDS) have a bulk density lower than gastric fluids and thus remain buoyant in the stomach for a prolonged period of time, without affecting the gastric emptying rate. While the system is floating on the gastric contents, the drug is released slowly at a desired rate from the system. These floating tablets mainly prepared for reduction of lag time and release the drug up to 12 hours and may also increase the bioavailability of the drugs by utilizing the drug to full extent avoiding unnecessary frequency of dosing. The purpose of this research was to develop and evaluated floating matrix tablets of sacubitril and valsartan. The floating matrix tablets of sacubitril and valsartan were prepared by direct compression method using altered concentrations of HPMC K4M, HPMC K100M, sodium alginate as polymers and sodium bicarbonate, citric acid as gas generating agent. FTIR, DSC studies conformed that there was no incompatibility between the polymers and the drug. Tablet preformulation parameters were within the pharmacopoeias limit. Tablets were evaluated by different parameters such as weight uniformity, content uniformity, thickness, hardness, in vitro release studies, buoyancy determination and kinetic analysis of dissolution data. The varying concentration of gas generating agent and polymers was found to affect on in-vitro drug release and floating lag time. Tablet showed ≤ 1min lag time, continuance of buoyancy for >12 h. The in-vitro drug release pattern of sacubitril and valsartan optimized floating tablets (F16) was fitted to different kinetic models which showed highest regression (r2 = 0.9838) for Higuchi model. The Optimized formulation (F16) showed no significant change in physical appearance, drug content, floating lag time, in vitro dissolution studies after 75%±5% RH at 40±20C relative humidity for 6 months. Prepared floating tablets of sacubitril and valsartan may prove to be a potential candidate for safe and effective controlled drug delivery over an extended period of time for gastro retentive drug delivery system.
Effect of Phaseolus vulgaris on E. coli induced peritonitis and bacteraemia in mice
Authors: Khadagwanshi Dipika , Trivedi Sonkia , Patel Preeti , Jha Megha 
Published: September 2019

Infectious or non-infectious peritonitis leads to systemic inflammation due to violation of the peritoneum which is often fatal. Evidences suggest that common bean (Phaseolus vulgaris L.) is a source of nutrients and contains phenolic compounds having antioxidant activity and its consumption has been linked with improved health benefits. The aim of the present investigation was evaluate the in vitro antibacterial, antioxidant activity and protective potential of the methanolic extract of P. vulgaris in E. coli induced model of peritonitis in albino wistar rats. Rats were pre-treated with 200 mg/kg and 400 mg/kg/bwt dose for 3 days and fourth day with E. coli (1×108 CFU/ml) strain and consecutively 3 days treatment. Mortality was monitored for 14 days. After the death of rats or completion of the experiment rats were sacrifice and kidney were used for our protocol. Colonies were count and statically analysis was done. Results showed dose dependent antibacterial activity. Thus the methanolic extract of P. vulgaris exhibited significant protection against E. coli induced peritonitis in normal rats. It significantly reduced the viable cells of E. coli when inoculated in rats. Activity is attributed to flavonoids and phenolic compounds. The present study thus suggests that methanolic extract of P. vulgaris significantly reverses peritoneal infection by E. coli in rats. It can be suggest that this medicinal formulation will be used as herbal medicine with no side effects. The high content of phenolic compounds, antioxidant activity and antibacterial activity of P. vulgaris indicate that they may impart health benefits when consumed and should be regarded as a valuable source of antioxidants. Thus, consumption of P. vulgaris seed along with coats might be recommended to gaining better nutritive benefits.
Keywords: P. vulgaris, Peritonitis, Antioxidant, Antibacterial, E. coli
Formulation Development & Evaluation of Buffered Tablet of Proton Pump Inhibitors Drug Rabeprazole Sodium
Authors: Kumari Mamta , Jain Nishi Prakash 
Published: September 2019

The aim of present study was to prepare buffered tablets of acid labile drug, Rabeprazole sodium for oral administration using buffering agents to protect a drug from gastric fluid. Rabeprazole belongs to a class of antisecretory compounds (substituted benzimidazole proton-pump inhibitors) that do not exhibit anticholinergic or histamine H2-receptor antagonist properties, but suppress gastric acid secretion by inhibiting the gastric H+, K+ATPase at the secretory surface of the gastric parietal cell. Rabeprazole blocks the final step of gastric acid secretion. The tablets were prepared by direct compression and wet granulation method. The formulations contain water soluble buffers such as sodium bicarbonate and trisodium phosphate as well as water insoluble buffers as magnesium oxide, magnesium hydroxide and calcium carbonate and crospovidone as superdisintegrant. Preformulation studies like angle of repose, bulk density, tapped density, Carr’s index, hausner’s ratios, DSC and drug/excipient compatibility study were conducted and evaluated for hardness, friability, weight variation, drug content, disintegration and in-vitro dissolution. In the present study, pH of F6 batch was found to be optimum and disintegration time is 42 sec. The drug release was found to show maximum drug release in case of F6 with 99.3% in 60 minutes. In case of stability studies study of the optimized batch, all the results were found to be satisfactory and within limits. There were no significant changes after the period of 1 month study.
Keywords: Rabeprazole sodium, Proton-pump inhibitors, Buffered tablet, Superdisintegrants, Buffering agents
In-Vitro Anti-Fungal Activity and Phytochemical Screening of Stem Bark Extracts from Ventilago denticulata
Authors: Devhadrao NV , Bansode AS , Shende VS , Thokal SH , Bhalerao SS , Bhalerao PB , Dhage OL , Tambe AB 
Published: September 2019

The objective of the present study was to assess the antifungal activity of pet. Ether extract, acetone extract, ethyl acetate, and ethanol bark extract of Ventilago denticulata (VD).The material was dried in shade made to a coarse powder and weighted quantity of the powder (1000 g) was subjected to hot percolation in a soxhlet apparatus using petroleum ether, ethyl acetate, acetone and ethanol, at a temperature range of 40-800C. Phytochemical tests were done in presence of phytoconstituents like glycosides, alkaloids, tannins, steroids, flavonoids. The anti-fungal activity was carried out by using cup method using Sabraud’s agar as medium. Plates were incubated at 250C for 42hr and later observed for zones of inhibition. The effect of the extracts on fungal isolates was compared with Griseofluvin at a concentration of 10 mg/ml. The Ethyl acetate extract at low as well as high doses gives antifungal effect. Pet-ether extract, acetone extract and ethanolic extract did not produce any antifungal effect at both doses. Ethyl acetate extract shows zone of inhibition at low dose (T1 10 mg/ml) 10 mm and at high dose (T2 20 mg/ml) 16 mm.
Keyword: Ventilago denticulata, Anti- fungal, Griseofluvin.
Quantum Dots: Method of Preparation and Biological Application
Authors: Gomase Amol , Sangale Sagar , Mundhe Akshay , Gadakh Pravin , Nikam Vikrant 
Published: September 2019

Quantum dots are inorganic semiconductor crystal of nanometer size which having distinctive conductive property depend on its size & shape. After administration of quantum dots parentally they identify target and bound them. Also quantum dots having light emitting property depend on size & shape. Quantum dots are prepared by chemical synthesis method include both organic & water phase synthesis & also by top- bottom approach. Tumor cell targeting & detection of pathogen & toxin are the main application of quantum dots & also in targeting drug delivery system. This review provides the overview of method of preparation of quantum dots & its biological application.
Keywords: Quantum dot, targeting drug delivery, biological application
Formulation Development and Evaluation of Herbal Toothpaste for Treatment of Oral Disease
Authors: Shukla Kavita Varma , Kumari Deepika 
Published: September 2019

Streptococcus mutans is the most common cause of tooth decay. Parabens and other commonly used as anti-Streptococcus agents in toothpaste industry have numerous side effects such as discoloration of teeth. The herbal extract of all three plants gives antimicrobial and anti-inflammatory activity and prevent and reducing the tooth decay, dental caries and given to freshness of mouth. The aim of present work was development and evaluation of herbal antimicrobial toothpaste containing Bark of Acacia nilotica, Acacia catechu and flower buds of syzygium aromaticum as herbal ingredients. Different types of formulations (F1-F6) were formulated using calcium carbonate as abrasive and Glycerine as humectant in varied concentrations. All the formulations were evaluated for various parameters like dryness, color, appearance, consistency, washability, pH, spreadability and foaming power. Polyherbal toothpaste containing hydroalcoholic extract of plants was tested for antimicrobial activity against Staphylococcus aureus and Streptococcus mutans with different concentrations of toothpaste were used (25, 50and 100 mg/ml). Among the tested bacteria used Staphylococcus aureus was found to be most sensitive to the formulated toothpaste as seen by zone of inhibition (19-24 mm) followed by Streptococcus mutans (13-18 mm). The results showed that the formulated polyherbal toothpaste is promising antimicrobial effects against both organisms. It may be safer compared to fully synthetic toothpaste. Further studies are warranted to prove safety and efficacy of the formulated polyherbal toothpaste.
Keywords: Streptococcus mutans, Acacia nilotica, Acacia catechu, syzygium aromaticum, polyherbal toothpaste
Formulation Development and Evaluation of Floating Microsphere of Famotidine for the Treatment of Peptic Ulcer
Authors: Rai Dharmendra , Pandey Durga , Jain Nishi Prakash , Jain Surendra Kumar 
Published: September 2019

The purpose of this research was to prepare a floating drug delivery system of famotidine. The floating microspheres can be prepared for the improvement of absorption and bioavailability of famotidine by retaining the system in the stomach for prolonged period of time. Floating microspheres of famotidine were prepared using different polymers like ethyl cellulose, hydroxy propyl methyl cellulose by solvent diffusion-evaporation method. The microspheres had smooth surfaces with free-flowing and good-packing properties. The yield of the microspheres was up to 73.32±0.14% and ethyl cellulose microspheres entrapped the maximum amount of the drug. Scanning electron microscopy confirmed their hollow structures with sizes in 331.6 nm. The prepared microspheres exhibited prolonged drug release and Percentage buoyancy was found to 73.25±0.23. The formulated batches were evaluated for percentage yield, particle size measurement, flow properties, percent entrapment efficiency, swelling studies. The formulations were subjected to stability studies and In-vitro release and release kinetics data was subjected to different dissolution models. It was concluded that developed floating microspheres of famotidine offers a suitable and practical approach for prolonged release of drug over an extended period of time and thus oral bioavailability, efficacy and patient compliance is improved.
Keywords: Famotidine, Solvent diffusion evaporation method, Ethyl cellulose, Hydroxyl propyl methyl cellulose
Good Statistical Practice: A Key To Effective and Safe Drug Product
Authors: Santosh Kumar Rada , Saisandeep Naidu G. 
Published: September 2019

In the pharmaceutical R&D the evaluation procedures play a key role in developing a potent graded product focusing on the various technical advancements it’s easy to overcome hazards.Emphasis is placed on the product’s development to reach specifications of USFDA ,US Pharmacopeia, National Formulary for achieving standards that provide insight on evaluation techniques of drug formulation.Adoption of guidance’s and guidelines cited will strive for achieving good laboratory practice(GLP) good clinical practice(GCP) and good manufacturing practice(cGMP).Embracing statistical approach provides accuracy and reliability of results.
Detection of Brain Tumor by Medical Image Processing
Authors: Mahajan Shivangi , Saini Sakshi 
Published: September 2019

Medical image processing is the most inspiring and developing field today. This paper labels the method of discovery & removal of brain tumor from patient’s MRI scan images of the brain. In this paper, a technique for separation of brain tumor has been developed on 2D-MRI facts which allow the documentation of tumor tissue with great accuracy and reproducibility compared to manual techniques. The first step of discovery of brain tumor is to patterned the symmetric and asymmetric Form of brain which will define the irregularity After this step the next step is segmentation which is built on two techniques 1) F-Transform (Fuzzy Transform) 2) Morphological operation. These two techniques are used to project the image in MRI. Now by this help of project we can sense the boundaries of brain tumor and calculate the real area of tumor.
Keywords: Brain tumor, medical image processing, MRI.
Effect of psycho educational intervention on level of anxiety among Hospitalized children: A systemic Literature review
Authors: Patel Niyati , Vageriya Vipin 
Published: September 2019

Background: Hospitalization and Disease can be the first crisis situation that a child encounters. Hospitalization may leads to increase the stress and level of anxiety among children and parents. An excessive or persistent state of anxiety can have a devastating effect on child’s physical and mental health. Psych education is an evidence-based therapeutic intervention for clients and their family members who help them to cope with illness and give the information as well as support to understand in better way. Psych education is helps to children and their family to minimize the emotional trauma during the hospital stay.
Objective: To evaluate the impact of psycho educational intervention on level of anxiety among hospitalized children.
Methods: A systematic literature review is conducted.
Electronic database search to Collect Literature: The following electronic databases are searched: ProQuest, Research gate, Pubmed, EBSCO, science direct, the British Nursing Index and the Cumulative Index to Nursing & Allied Health Literature (CINHAL) and journal available in library.
Result: collected review of literature result shows that psycho educational intervention considers a positive effect on reduce the level of anxiety among hospitalized children.
Conclusion: psych educational intervention is cluster of the strategies like play therapy, storytelling, guided imagery etc. It is a non- invasive and safe intervention which helps to reduce the anxiety level.
Keywords: psych educational intervention, anxiety level, hospitalized children, search engine, counselling