bluuebunny/crossref_metadata_2025_split huggingface dataset:
Исследование микроделеций Y-хромосомы и сперматологических нарушений у пациентов с Y-аутосомными транслокациями
Authors: М.И. Штаут , Н.В. Опарина , М.В. Андреева , Л.Ф. Курило , О.А. Соловова , Т.М. Сорокина , Н.В. Шилова , А.В. Поляков , В.Б. Черных 
Published: October 2024

Y-aутосомные транслокации – редкие структурные аномалии хромосом, которые оказывают различное влияние на развитие половой системы, гаметогенез и фертильность. В статье представлены результаты генетического и сперматологического обследования группы из 14 мужчин с Y-аутосомными транслокациями. Выполняли цитогенетическое, молекулярноцитогенетическое (FISH), молекулярно-генетическое и комплексное сперматологическое (стандартный спермиологический анализ и количественный кариологический анализ незрелых половых клеток из осадка эякулята – ККА НПК) исследования. У всех пациентов выявлены немозаичные Y-аутосомные перестройки: 10 сбалансированных транслокаций (с аутосомами 1; 8; 13-16; 20; 21) и 4 несбалансированные перестройки (с аутосомами 5, 13, 22). Пациенты являлись фенотипически нормальными мужчинами, без аномалий формирования пола, пороков развития, нарушения роста, физического развития, умственной отсталости. По результатам молекулярного анализа Y-хромосомы ген SRY выявлен у13 пациентов, патогенные микроделеции в локусе Yq11.2 (AZFa+b+c, AZFb+c) обнаружены у двух пациентов. У одного пациента молекулярный анализ не проводился. По данным сперматологического анализа у 11 пациентов обнаружена азооспермия, у одного – олигозооспермия тяжелой степени, у одного – олигоастенозооспермия, у одного – нормозооспермия. Признаки полного или частичного блока сперматогенеза в профазе I мейоза выявлены у 3 из 7 пациентов, которым выполнен ККА ПНК.
Y-autosome translocations are rare structural chromosomal abnormalities that have a different effect on the reproductive system, gametogenesis and human fertility. The article presents the results of genetic and semen examination of a group of 14 men with Y-autosomal translocations. Cytogenetic, molecular cytogenetic, molecular cytogenetic (FISH), molecular genetic and complex semen studies, including standard semen analysis and quantitative karyological analysis of immature germ cells (QKA of IGCs) from the ejaculate sediment, were performed. Non-mosaic (10 balanced and 4 unbalanced) translocations involving the Y chromosome and one of the autosomes (chromosomes 1, 5, 8, 13-16, 20-22) were detected. The patients were phenotypically normal men, without disorders of sex development, congenital malformations, growth and physical development disorders, mental retardation. Molecular analysis of the Y chromosome performed in 13 patients has detected the SRY locus in all patients; pathogenic Yq11 microdeletions (AZFa+b+c, AZFb+c) were found in two patients. Semen analysis shown various diagnosis, including azoospermia (n=11), severe oligozoospermia (n=1), oligoastenozoospermia (n=1), and normozoospermia (n=1). Signs of a complete or partial фдarrest at prophase I of meiosis were detected in 3 out of 7 patients who underwent QKA of IGCs.
Молекулярно-цитогенетическая диагностика парацентрической инверсии 8p23.1 в кариотипе матери пациента с invdupdel(8p) на кольцевой хромосоме 8
Authors: А.А. Кашеварова , В.В. Деменева , А.С. Зуев , М.Е. Лопаткина , Д.А. Федотов , С.А. Васильев , И.Н. Лебедев 
Published: October 2024

Сочетание инвертированной дупликации с терминальной делецией 8р (invdupdel(8p)) – редкая хромосомная перестройка, проявляющаяся задержкой нейропсихического развития, умственной отсталостью, пороками сердца и аномалиями мозга. Известно, что полиморфная парацентрическая инверсия в структуре хромосомы 8 матери может привести к перестройке invdupdel(8р) у ее ребенка. Нами создана система зондов для поиска FISH-методом скрытой инверсии в хромосоме 8 матери пациента с задержкой развития, гипотонией, черепно-лицевыми аномалиями и кольцевой хромосомой 8, обусловленной invdupdel(8р). Инверсия в структуре хромосомы 8 у женщины выявлена, что указывает на необходимость проведения пренатальной диагностики при наступлении беременности.
The combination of an inverted duplication with a terminal 8p deletion (invdupdel(8p)) is a rare chromosomal rearrangement that manifests with neurodevelopmental delay, intellectual disability, heart defects, and brain abnormalities. It is known that a polymorphic paracentric inversion in the structure of mother’s chromosome 8 can lead to invdupdel(8p) in her child. We have created a system of DNA-probes to search with the FISH-method for cryptic inversion in chromosome 8 of the mother of a patient with developmental delay, muscle hypotonia, craniofacial anomalies and ring chromosome 8 caused by invdupdel(8p). An inversion in the structure of chromosome 8 in a woman was revealed, which indicates the need for prenatal diagnosis in the case of pregnancy.
Инновации кормового поведения птиц: исторический и эколого-географический анализ явления
Authors: А.Г. Резанов , А.А. Резанов 
Published: October 2024

На основе литературных данных и собственных полевых исследований авторов проведен исторический и эколого-географический анализ инноваций кормового поведения птиц. Выделены естественные и антропогенные инновации поведения, исторически сложившиеся и новые, широко распространенные и локальные.
Based on literature data and their own field research by the authors conducted historical and ecological-geographical analysis of innovations of feeding behaviour of birds. Natural and anthropogenic behavioural innovations, historical and new, widespread and local, have been highlighted.
К вопросу о структуре образовательного пространства педагогического университета в условиях цифровой трансформации образования
Authors: Н.Г. Михайлов 
Published: October 2024

В статье рассматриваются возможности создания модели информационно-образовательного пространства университета для подготовки бакалавров по специальности Педагогическое образование направления Физическая культура . Модель основана на инновационной концепции физической культуры, предусматривает использование современных средств и методов физического воспитания в условиях цифровой трансформации образования. Представлена характеристика содержательных элементов такой модели. Показаны возможные подходы к насыщению ее содержания.
The article discusses the possibility of creating a model of the universitys information and educational space to prepare bachelors in the specialty of Educational education of the field of Physical culture . The model is based on an innovative concept of physical culture, which uses modern means and methods of physical education in the context of the digital transformation of education. The characteristic of the content elements of such a model is presented.Possible approaches to saturation of the content of such a model.
Методика организации образовательного геокешинга
Authors: Т.П. Грушина 
Published: October 2024

В статье рассматриваются методические особенности организации образовательной командной игры с применением геокешинга с целью реализации межпредметных связей, повышения познавательного интереса учащихся.
The article deals with the methodological features of the organization of educational team game with the use of geocaching, in order to implement interdisciplinary connections, increase the cognitive interest of students.
Pelatihan Digital Marketing Dan Pemasaran Produk Pada Kelompok UMKM
Authors: Pradiptya Adhi , Kusumawati Citra Andriani , Ariefiantoro Teguh 
Published: October 2024

Pesatnya perkembangan teknologi digital saat ini tentu saja berimbas pada dunia pemasaran. Tren pemasaran beralih dari yang semula dilakukan secara tradisional, berkembang menjadi pemasaran secara digital. Hal ini tentu menimbulkan biaya yang lebih besar dengan jangkauan yang terbatas jika dibandingkan dengan penggunaan teknologi digital yang tepat. Kemudian kurangnya kemampuan pelaku UMKM di Kelurahan Bojongsalaman Semarang dalam pemasaran produk membuat beberapa anggota UMKM belum menemukan cara menjual barangnya dengan tepat. Padahal produk yang dihasilkan sangat menarik dengan kualitas yang terjamin. Tujuan kegiatan PKM ini adalah memberikan pelatihan untuk meningkatkan kemampuan para pelaku UMKM dalam hal teknologi digital dan memberikan pelatihan untuk pemasaran produk dengan membuat konten media sosial yang menarik untuk calon konsumen. Oleh sebab itu, tim pengabdian kepada masyarakat melakukan kegiatan Pelatihan Digital Marketing Dan Pemasaran Produk Pada Kelompok UMKM di Kelurahan Bojongsalaman Semarang. Kegiatan pengabdian kepada masyarakat akan dilaksanakan dalam bentuk pelatihan pemasaran dengan mengenalkan pemasaran digital untuk efisiensi biaya pemasaran. Selain itu, kegiatan akan dilakukan pre-test dan post-test untuk mengetahui peningkatan kemampuan pelaku UMKM dalam penggunaan media pemasaran. Hasil pengabdian memperlihatkan peningkatan pengetahuan dan kemampuan pelaku usaha dalam memahami dan menggunakan teknologi digital dan social media. Terdapat beberapa pelaku UMKM yang sudah memanfaatkan teknologi digital, namu masih banyak yang tidak menggunakannya karena kesusahan dan tidak mengguasainya. Penguasaan teknologi digital dengan penggunaan media pemasaran digital yang tepat, akan membuat efisiensi biaya pemasaran dicapai serta jangkauan pemasaran yang lebih luas oleh masing-masing anggota kelompok UMKM.
Evaluation of the effectiveness of topical use of sertaconazole in dermatophytosis
Authors: Bolotna L.А. 
Published: October 2024

Objective — to evaluate the effectiveness of a cream containing sertaconazole nitrate 2 % (Onabet 2 % cream) in patients with various forms of dermatophytosis.
Materials and methods. 32 patients aged 21—50 were under outpatient observation. The duration of dermatophytosis varied from several weeks to 3 months. Tinea corporis was diagnosed in 25.0 % of patients, foot mycosis in 43.8 %, and axillary mycosis in 31.2 %. The diagnosis was based on the clinical manifestations of the disease and the results of microscopic examination with potassium hydroxide (PH). The clinical picture was evaluated based on the presence of subjective and objective signs (itching, erythema, scaling, vesicles/maceration, pustules) and their intensity according to the scale: 0 points — absence, 1 point — mild, 2 points — moderate, 3 points — severe. The area of skin damage was determined using the «rule of the palm» in patients. The final score of clinical manifestations was calculated by adding the individual scores of each symptom and the value of the area of the affected skin. Onabet 2 % cream was applied by patients twice a day to the affected area of the skin for 4 weeks.
Results and discussion. As a result of topical treatment, positive dynamics regarding the clinical manifestations of dermatophytosis were noted in all patients. The regression of inflammatory symptoms (itching, erythema, wetting in 65.5, 40.6 and 71.4 % of patients, respectively) by the end of the 1st week of treatment serves as evidence of anti-fungal, anti-inflammatory and anti-pruritic effects. The terms of regression of clinical manifestations of dermatophytosis depended on the clinical form of the infection. Clinical remission by the end of the 1st week of therapy in 34.4 % of patients, clinical remission and mycological negativity by the end of the 2nd week in 81.3 % of patients testify to the rapid effect of the drug. At the end of the 6th week, clinical success was achieved in 93.7 %, mycological (pathogen eradication) in 100.0 % of patients. Remote observation results within 3 months showed no disease recurrence in all patients. Side effects during treatment were not registered.
Conclusions. Onabet cream 2 % is a modern topical antimycotic with a wide spectrum of action; its use twice a day for 1 month allows for achieving clinical cure in 93.7 %, etiological cure in 100 % of patients with dermatophytes (tinea corporis, tinea pedis, and tinea cruris). The high effectiveness and safety of Onabet cream in treating dermatophytosis allow us to recommend this topical agent for treating patients with dermatophytosis.
Cognitive bias and stock investment decisions among the individual investors
Authors: Mohan Prasad Sapkota  , Shiva Bhandari  
Published: October 2024

Decision-making is a complex activity and cannot be made in a vacuum. Human behavior is the fundamental concern for stock investment decisions of the individual investors. This study sought to establish the cognitive biases which influence the individual investors’ stock investment decisions. Descriptive cum causal-comparative research design was employed. A sample of 385 individual investors was used among the stock investors in Chitwan district. Final usable responses were collected from 273 individual investors via 5-point Likert-type self-administered closed-end structured questionnaires. Data were analyzed through descriptive and inferential statistics by using SPSS - 25 and MS excel. This study found that overconfidence bias, excessive optimism, herding bias, and accounting information has significant positive influence on equity investment decisions of the investors. Evidence indicates that cognitive bias plays the significant role for stock investment decisions of the investors. Finally, this study concluded that investors should properly aware and handle such biases for better investment decisions to obtained the appropriate return on investment decisions and such biases should be properly handled by the investors through participation in training, education, seminar and information analysis. The study also suggests that the NEPSE and SEBON should offer proper investment education, financial literacy related to stock market and knowledge to investors in order to minimize the adverse effects of such biases.
PENERAPAN PRINSIP-PRINSIP PENATAAN DAERAH PEMILIHAN PADA PEMILIHAN UMUM ANGGOTA DEWAN PERWAKILAN RAKYAT DAERAH KABUPATEN BANGGAI TAHUN 2024
Authors: Sucipto Dri , Sukmana Oman , Wahyudi Wahyudi , Moh. Nur Nirwan 
Published: October 2024

Penelitian ini dibertujuan untuk mengetahui penerapan prinsip-prinsip penataan daerah pemilihan diwilayah Kabupaten Banggai dan untuk melihat berbagai permasalahan yang mempengaruhi penerapan prinsip-prinsip penataan daerah pemilihan. Penelitian ini dilakukan di Kabupaten Banggai dengan menggunakan metode empiris. Data dikumpulkan melalui penelitian lapangan dan studi kepustakaan, kemudian dianalisis menggunakan metode deskriptif kualitatif. Dari hasil penelitian, menemukan bahwa Daerah pemilihan (dapil) adalah salah satu faktor penting dalam membangun sistem pemilu dan sering menjadi persoalan dalam setiap penyelenggaraan pemilu. Dengan demikian, dapil memainkan peran krusial dalam proses pemilihan umum, karena menjadi fokus strategi politik dan kampanye calon legislatif diterapkan. Alokasi kursi yang tepat dan adil berdasarkan dapil menjadi esensi untuk menciptakan perwakilan yang proporsional dan demokratis di DPR. Oleh sebab itu dalam penyusunan daerah pemilihan (dapil) harus memperhatikan antara lain: prinsip kesetaraan nilai suara, prinsip proporsionalitas, dan prinsip integralitas wilayah adalah fundamental agar semua orang merasa diwakili dengan baik dan prosesnya adil. Namun, dalam praktiknya, seringkali pembentuk undang-undang mengabaikan prinsip-prinsip ini. Hal ini menyebabkan ketidakseimbangan dalam representasi politik, di mana suara individu di satu dapil mungkin memiliki nilai yang berbeda dibandingkan dengan suara di dapil lainnya. Tanpa adanya perbaikan ini, sistem pemilu akan terus menghasilkan representasi yang tidak akurat dan tidak adil, yang pada gilirannya akan mengikis kepercayaan publik terhadap institusi demokrasi.
Behavior of RC Columns with Different Internal Ties Configurations Subjected to Axial Load: Numerical Study
Authors: Elbakry Hazem M. , Ebeido Tarek I. , El-Tony El-Tony M. , Ali Momen M. 
Published: October 2024

Reinforced concrete columns use a lot of ties, particularly inner cross-ties in large columns. The major goal of this work is to create new approaches for horizontal reinforcement in RC columns and evaluate their effect on column behaviour. The suggested V-ties as transverse reinforcement, which would replace the cross-ties features, are cost-effective. They make it possible to complete projects faster and spend less on labour and material. Numerical study is carried out. FE models for sixty (60) specimens were developed. Each specimen is modeled with different cross-sections (250*250 mm), (500*500 mm), (1000*1000 mm), (250*500 mm) and (250*1000 mm) at different values of spacing 50 mm, 100 mm, and 200 mm. It was discovered that adopting V-tie techniques instead of traditional ties might increase column axial load capacity, reduce early local buckling of longitudinal reinforcing bars, and enhance the concrete core confined to RC columns.
The association between low serum vitamin D level & periodontal diseases in Bangladeshi population- An observational study
Authors: Rinku Shaikh Ahmed , Afroz Jahan Sadia , Sadat S M Anwar , Barma Paromita , Kabir Md Humayun 
Published: October 2024

Aims: Bangladeshi population (20-45 age) presents early loss of tooth without any history of systemic disease. Low serum vitamin D level is one of the factors of early tooth loss. The aim of the study is to assess the significance of low or insufficient serum vitamin D level as a factor of early tooth loss in Bangladesh perspective.
Materials and Methods: An observational study was performed in dental unit of TMSS Medical College from January 2021 to December 2022 after ethical clearance of IRB of this institute. Total number of patients was 70 selected by non-random sampling (judgment sampling) who fulfilled the inclusion and exclusion criteria. We assessed the variable like gingivitis, periodontal pocket & tooth mobility clinically. The depth of the periodontal pocket & gingivitis was assessed by the periodontal probe & the mobility by using a blunt instrument & feel with the fingers before & after Vit D supplementation. Data were processed and analyzed using computer software SPSS version 26.0.
Results: Deficiency of low serum vit D level has significant effect on periodontal bone resorption and after correction of serum vit D level resulted clinical improvement on periodontal health.
Conclusion: Vitamin D deficiency may place subject at risk of developing chronic periodontitis.
J Bangladesh Coll Phys Surg 2024; 42: 363-367
Pencak Silat Profil Komposisi Tubuh dan Daya Tahan Kardiorespirasi Atlet Pencak Silat Pelatda Jawa Barat
Authors: Muharamsyah Ariya , Haqiyah Aridhotul 
Published: October 2024

Penelitian ini dilatar belakangi oleh belum diketahuinya profil komposisi tubuh dan daya tahan kardioresirasi atlet pencak silat pelatda Jawa Barat. Penelitian ini, penelitian deskripsi tentang tingkat kebugaran jasmani. Tujuan penelitian ini adalah untuk mengetahui profil profil komposisi tubuh dan daya tahan kardioresirasi atlet pencak silat pelatda Jawa Barat
Jenis penelitian ini adalah penelitian deskriptif yang bertujuan untuk mengetahui profil komposisi tubuh dan daya tahan kardioresirasi atlet pencak silat pelatda Jawa Barat. Metode yang digunakan dalam penelitian ini adalah survei. Instrumen tes menggunakan alat timbangan BIA yang akan mengukur BMI, visceral fat, Body fat dan skeletal muskel dan tes daya tahan menggunakan instrumen tes bleep test. Populasi dalam penelitian ini adalah atlet pencak silat pelatda Jawa Barat dan menggunakan total sampling yaitu 9 atlet putra dan 9 atlet putri. Teknik yang dipakai dalam analisis data penelitian adalah menggunakan statistik deskriptif dengan metode analisis deskriptif analisis presentase.
Dari hasil penelitian penulis memperoleh hasil body fat ada 17% atlet memiliki body fat tinggi dan ada 83% atlet memiliki body fat normal dengan nilai rata-rata 19,6, visceral fat 11% atlet memiliki visceral fat tinggi dan ada 89% atlet memiliki visceral fat normal dengan nilai rata-rata 5,0, BMI ada 17% atlet memiliki BMI berlebih dan ada 83% atlet memiliki BMI normal dengan nilai rata-rata BMI 22,7. Skeletal muscle ada 17% atlet memilikimemiliki skeletal muscle tinggi dan ada 83% atlet memiliki skeletal muscle normal dengan nilai rata-rata 32,2. Vo2Max ada 100% atlet memiliki Vo2Max tinggi dengan nilai rata-rata 52,4. Bisa disimpulkan bahwa komposisi tubuh dan daya tahan kardiorespirasi atlet pencak silat pelatda Jawa Barat sangat baik dan ideal penting bagi atlet dan pelatih agar menjaga kondisi fisik yang ideal agar mendapatkan hasil yang maksimal.
Electrospun fibers of zein and pea protein to create high-quality fibrous structures in meat analogs
Authors: da Trindade Letícia G. , Zanchet Letícia , Bonsanto Fabiana Perrechil , Braga Anna Rafaela Cavalcante 
Published: October 2024

IntroductionThe importance of developing plant-based meat similar to animal meat lies in the fact that sensory similarity is a crucial factor in encouraging consumers to adopt this alternative.MethodologyThe present study reports the morphology, hydrophilicity, and thermal analysis of different fibers obtained by the electrospinning method. In the first step of this work, zein and zein/poly(ethylene oxide) (PEO) in 80% aqueous ethanol solution with varying concentrations of these polymers were investigated.Results and DiscussionIt was observed that the diameters of the electrospun fibers are related to the concentration and viscosity of the solutions. Moreover, the addition of small percentages of PEO makes the fibers more hydrophilic and leads to an increase in the polymeric solution viscosity. Because of its low toxicity, PEO is used in various edible products. In the second step of this work, an ideal zein/PEO combination was found to allow the pea protein (PP) to be electrospun. Adding PP to the zein/PEO blend (20:1) leads to a more hydrophilic fiber and improves thermal stability. The results suggest that the zein/PEO and zein/PEO/PP blends can offer an innovative solution to enhance the texture and appearance of plant-based meats. These simulated electrospun fibers can mimic the fibers in animal meat and are a potential alternative to provide a sensory experience as close to animal meat as possible.