bluuebunny/crossref_metadata_2025_split huggingface dataset:
Participants' Perceptions and the Implementation of a Physical Fitness Screen for Aging Adults
Authors: Puthoff Michael 
Published: August 2019

Background and Purpose:
Physical therapists have been called upon to conduct annual screens focused on optimizing movement and slowing the progression of impairments in body functions. Screens are thought to be important, especially in an aging population, but there are limited data on participants' impression of screening and their implementation into practice. The first objective of this study was to examine aging adults' perception of a physical therapist–led physical fitness screening tool, the Adult Functional Independence Test (A-Fit). The A-Fit is a comprehensive screen that includes tests of posture, flexibility, balance, mobility, endurance, and strength for those aged 50 years and older. The second objective was to examine the practicality and implementation of the A-Fit, taking into consideration time requirements and the ability of the test components to identify deficits.

Methods:
This was a cohort study using a convenience sample of 37 participants (26/11 females/males, mean age = 59.6 years). A physical therapist performed the A-Fit to assess participants' physical fitness and then developed a physical activity plan to address the participants' deficits and goals. Performance on the A-Fit, the relationship between the components of the A-Fit, and time to complete the A-Fit were examined. One week after the session, participants' perceptions of the A-Fit and the overall session were assessed by survey.

Results and Discussion:
Participants strongly agreed that the screen was beneficial, useful, and worth their time. Fifty-eight percent of participants would repeat the A-Fit annually and 42% would pay for this service. Seventy-four percent reported that they would pay between $1 and $100. The average session length was 75 (SD = 13.4) minutes. On average, participants had 5.2 (SD = 3) deficits in physical fitness. Deficits in upper body strength and balance were the most frequent areas of deficits. Only single leg stance balance and ankle strength were highly correlated indicating that most of the A-Fit components were measuring different aspects of fitness.

Conclusion:
The A-Fit could be a feasible screening tool for physical therapists to implement in the clinical setting and have value in identifying aging adults with declines in physical fitness and those who would benefit from further interventions.
Preparing for a National Weightlifting Championship: A Case Series
Authors: Travis S. Kyle , Mizuguchi Satoshi , Stone Michael H. , Sands William A. , Bazyler Caleb D. 
Published: August 2019

Abstract
Travis, SK, Mizuguchi, S, Stone, MH, Sands, WA, and Bazyler, CD. Preparing for a national weightlifting championship: A case series. J Strength Cond Res 34(7): 1842–1850, 2020—This study aimed to characterize psychological, physiological, and performance changes of a high-level female (24.5 years; 53.8 ± 0.3 kg; 155.4 cm) and male (25.8 years; 92.7 ± 1.2 kg; 189 cm) weightlifter over 28 weeks while preparing for a national championship. Body mass, hydration, psychological inventories, serum biomarkers, vastus lateralis muscle cross-sectional area (CSA), and squat jump (SJ) performance were assessed weekly beginning 11 weeks from the competition date. Weightlifting performance goals were met for the female athlete (actual total = 159 kg) but not for the male athlete (actual total = 292 kg). Reductions in vastus lateralis CSA possibly took place the week leading into competition for both athletes. Both athletes reported positive recovery-stress states on the day of competition relative to baseline values. Fluctuations between steroid hormone concentrations and inflammatory markers were unpredictable and inconsistent for both athletes throughout the training program. Unloaded SJ height and rate of force development were the highest on competition day for both athletes. Based on these findings, it is possible for high-level male and female weightlifters to achieve and maintain peak preparedness 3–4 days before competition following a 1-week overreach and 3-week exponential taper, where training volume-load is reduced by half and intensity maintained or slightly increased relative to pretaper values. Furthermore, the short recovery and stress scale and SJ testing seem to be useful tools for sport scientists and coaches when monitoring high-level weightlifters preparing for competition.
Safety of medical adjustment and confirmatory testing in the diagnostic work-up of primary aldosteronism
Authors: Heinrich Daniel A , Adolf Christian , Quinkler Marcus , Holler Finn , Lechner Benjamin , Nirschl Nina , Sturm Lisa , Görge Veronika , Beuschlein Felix , Reincke Martin 
Published: August 2019

Objective
Saline infusion test (SIT) and captopril challenge test (CCT) are standard confirmatory procedures routinely used in the diagnostic work-up of primary aldosteronism (PA). However, side effects and complications during testing have not been systematically studied.

Design
We performed a cohort study with patients undergoing SIT and/or CCT in two centers from 2016 until 2018.

Methods
We studied 272 study participants with suspected PA enrolled at two outpatient centers in Germany. We assessed the frequency and severity of side effects during adjustment of blood pressure medication and during SIT and CCT.

Results
During the adjustment phase prior confirmatory testing, side effects including palpitations, headaches, edema and hypertensive episodes occurred in 18.4% of study participants. Side effects were associated with higher defined daily doses (DDD) (r = 0.25, P < 0.005), number of antihypertensive drugs (r = 0.285, P < 0.005) and higher blood pressure (r = 0.145, P = 0.019). During SIT, 17.5% of study participants had side effects, associated with higher blood pressure (systolic: r = 0.541, P < 0.0005; diastolic: r = 0.426, P < 0.0005) and DDDs (r = 0.727, P < 0.0005). During CCT, only 1.5% of study participants developed side effects.

Conclusions
In contrast to the high rate of side effects during SIT, CCT appears to be the safer test with a very low event rate. This makes CCT especially suitable for severely hypertensive patients.
Adaptation by Loss of Heterozygosity inSaccharomyces cerevisiaeClones Under Divergent Selection
Authors: James Timothy Y , Michelotti Lucas A , Glasco Alexander D , Clemons Rebecca A , Powers Robert A , James Ellen S , Simmons D Rabern , Bai Fengyan , Ge Shuhua 
Published: August 2019

AbstractLoss of heterozygosity (LOH) is observed during vegetative growth and reproduction of diploid genotypes through mitotic crossovers, aneuploidy caused by nondisjunction, and gene conversion. We aimed to test the role that LOH plays during adaptation of two highly heterozygous Saccharomyces cerevisiae genotypes to multiple environments over a short time span in the laboratory. We hypothesized that adaptation would be observed through parallel LOH events across replicate populations. Using genome resequencing of 70 clones, we found that LOH was widespread with 5.2 LOH events per clone after ∼500 generations. The most common mode of LOH was gene conversion (51%) followed by crossing over consistent with either break-induced replication or double Holliday junction resolution. There was no evidence that LOH involved nondisjunction of whole chromosomes. We observed parallel LOH in both an environment-specific and environment-independent manner. LOH largely involved recombining existing variation between the parental genotypes, but also was observed after de novo, presumably beneficial, mutations occurred in the presence of canavanine, a toxic analog of arginine. One highly parallel LOH event involved the ENA salt efflux pump locus on chromosome IV, which showed repeated LOH to the allele from the European parent, an allele originally derived by introgression from S. paradoxus. Using CRISPR-engineered LOH we showed that the fitness advantage provided by this single LOH event was 27%. Overall, we found extensive evidence that LOH could be adaptive and is likely to be a greater source of initial variation than de novo mutation for rapid evolution of diploid genotypes.
Environmental and Leadership Factors as Correlates of Team Performance Satisfaction of North-East Football Clubs in Nigeria Premier League
Authors: Tikon Bulus , Likki Nahson, Hananiah, , Hamafyelto Stephen, Sana’ah 
Published: August 2019

This study examined cohesion (Environmental and Leadership) factors as correlates of team performance satisfaction of North- East Football Clubs in Nigeria Premier League in 2013/2014 season. To achieve this, the study was guided by two hypotheses. A correlational research design was used for this study and the population for the study was made up of all the registered players of three north- east football clubs in Nigeria premier league in 2013/2014 season. Comprehensive sampling technique was used for the study. One hundred and five (105) players were used for the study. A modified 52- item questionnaire and 17- item Self – Developed scale on team Performance Satisfaction Questionnaire (TPSQ) were used to collect information from the respondents with a reliability coefficient of 0.856. A modified 4 point Likert Type Scale was used. The Response Mode of Strongly Agree, Agree, Disagree and Strongly Disagree was used. Data were analyzed using inferential statistics of Pearson Product Moment Correlation Coefficient (PPMC) to test the null hypotheses at 0.05 level of significance. The results showed that there is significant correlation between cohesion (Environmental and Leadership) factors and team performance satisfaction in the North – East Football Clubs in Nigeria Premier League. This showed that there is team performance satisfaction in three (El-Kanemi Warrirs Football Club, Gombe United Football Club and Taraba United Club) clubs in the North-East Nigeria in 2013/2014 premier league. It was recommended among other things that Coaches and players should adopt good leadership styles to enhance team cohesion and team performance satisfaction
Algorithms of Processing Fluorescence Signals for Mass Parallel Sequencing of Nucleic Acids
Authors: Manoilov Vladimir , Borodinov Andrew , Zarutsky Igor , Petrov Alexander , Kurochkin Vladimir 
Published: August 2019

Determination of the nucleotide sequence of DNA or RNA containing from several hundred to hundreds of millions of monomers units allows to obtain detailed information about the genome of humans, animals and plants. The deciphering of nucleic acids’ structure was learned quite a long time ago, but initially the decoding methods were low-performing, inefficient and expensive. Methods for decoding nucleotide nucleic acid sequences are usually called sequencing methods. Instruments designed to implement sequencing methods are called sequencers.
Sequencing new generation (SNP), mass parallel sequencing are related terms that describe the technology of high-performance DNA sequencing in which the entire human genome can be sequenced within a day or two. The previous technology used to decipher the human genome required more than ten years to get final results.
A hardware-software complex (HSC) is being developed to decipher the nucleic acid sequence (NA) of pathogenic microorganisms using the method of NGS in the Institute for Analytical Instrumentation of the Russian Academy of Sciences.
The software included in the HSC plays an essential role in solving genome deciphering problems. The purpose of this article is to show the need to create algorithms for the software of the HSC for processing signals obtained in the process of genetic analysis when solving genome deciphering problems, and also to demonstrate the capabilities of these algorithms.
The paper discusses the main problems of signal processing and methods for solving them, including: automatic and semi-automatic focusing, background correction, detection of cluster images, estimation of the coordinates of their positions, creation of templates of clusters of NA molecules on the surface of the reaction cell, correction of influence neighboring optical channels for intensities of signals and the assessment of the reliability of the results of genetic analysis
Non‐paraneoplastic limbic encephalitis associated with antibodies to potassium channels leading to bilateral hippocampal sclerosis in a pre‐pubertal girl
Authors: Kröll‐Seger Judith , Bien Christian G. , Huppertz Hans‐Jürgen 
Published: August 2019

ABSTRACTLimbic encephalitis (LE) is increasingly recognized as a precipitating factor of adult onset temporal lobe epilepsy frequently associated with bilateral hippocampal damage. So far, clinical data in children are rare and only comprise paraneoplastic forms of LE. We describe a 13‐year‐old pre‐pubertal girl in whom non‐paraneoplastic LE was diagnosed according to diagnostic criteria proposed by Bien and Elger (2007). The girl presented with a subacute syndrome comprising memory impairment, affective disturbances, and refractory temporal lobe seizures. Serial MRI scans demonstrated an initial temporomedial swelling with T2/FLAIR signal increase progressing to bilateral hippocampal atrophy within seven months. Two years after onset of symptoms, antibodies to potassium channels were found to be slightly elevated. Immunosuppressive therapy with steroid‐pulses was followed by a transient reduction of seizure frequency, even though this was started more than two years after onset of first symptoms. However, extended immunotherapy was refused by the patient's parents, so no full assessment of the treatment response was possible. In conclusion, this case shows that non‐paraneoplastic LE leading to mesial temporal lobe epilepsy is not restricted to adult patients. The proposed diagnostic criteria therefore should be adapted for paediatric patients. Patients may profit from immunosuppressive therapy even when it is started at a late stage with already overt hippocampal sclerosis.
Efficacy and tolerability of zonisamide in idiopathic generalized epilepsy
Authors: Marinas Ainhoa , Villanueva Vicente , Giráldez Beatriz G. , Molins Albert , Salas‐Puig Javier , Serratosa Jose M. 
Published: August 2019

ABSTRACTObjectiveThe objective of this study is to evaluate the efficacy and safety of zonisamide (ZNS) for the treatment of idiopathic generalized epilepsies (IGEs).MethodsThirteen patients with different types of IGEs who were treated with ZNS between the years 2006 and 2008 were identified. Efficacy and tolerability were assessed at months 6 and 12 post‐treatment. Response was defined as a 50% or greater reduction in seizure frequency.ResultsTwelve patients (92.3%) continued with ZNS at month 6, and 11 (84.6%) at month 12. Mean daily dose was 319 mg (range 100‐500 mg/d). Response was achieved at month 6 in eight of the 12 patients that continued with ZNS (66.6%), of which 7 were seizure‐free (58.3%). At month 12, eight of the 11 patients that continued with ZNS were responders (72.7%) and 6 were seizurefree (63.6%). For different types of seizures, better responses were observed for absences and generalized tonic‐clonic seizures. Four out of 13 patients (30.7%) experienced adverse events and in two (15.3%), these led to withdrawal.ConclusionIn this retrospective study, ZNS showed efficacy and tolerability for the treatment of different types of IGEs. Limitations include a small sample size and a relatively short period of follow‐up. Our results are promising and justify the need for prospective controlled trials in IGE.
Status epilepticus in Wilson's disease
Authors: Knight Elia M. Pestana , Gilman Sid , Selwa Linda 
Published: August 2019

ABSTRACTRationale. Seizures occur in Wilson's disease (WD), with prevalence figures as high as 4‐6% in specialized academic centers, but status epilepticus is rare. We report a patient with WD who developed non‐convulsive status epilepticus (SE) during therapy with Tetrathiomolybdate (TTM) and review the last 20 years of the relevant literature. Case report. A 55 year‐old right handed man with WD who had parkinsonian features and hepatic cirrhosis was admitted for seizures. Seizures began on week 4 of treatment with TTM (Phase III Study of Tetrathiomolybdate Dose Regimen in Neurological Wilson's Disease). Seizures were characterized by forced clonic eye, head deviation to the right and right arm posturing followed by unresponsiveness, bilateral eye blinking and right hand automatisms. EEG confirmed frequent left frontal seizures. He developed non‐convulsive status epilepticus (NCSE) with electrographic seizures every 5‐10 minutes, lasting for 1‐2 minutes each. Seizures were controlled within 24 hours with fosphenytoin, midazolam and levetiracetam. Brain MRI showed diffuse atrophy, mineralization of the basal ganglia, and patchy FLAIR increase signal in the left frontal lobe. Literature review. We found reports of 6 WD patients with SE, two upon presentation of the disease and before copper removing treatment, and four after months to years of treatment with D‐penicillamine. Conclusion. SE occurs rarely in WD, and our case is the only one reported to develop SE during treatment with TTM. As the literature documented two patients with WD who developed SE prior to copper deposit treatment, our hypothesis is that seizures in WD can be the result of the progression of the disease or a combination of factors but not necessarily due to its treatment alone.
Impairment of the cortical GABAergic inhibitory system in catatonic stupor: a case report with neuroimaging
Authors: Iseki Kazumi , Ikeda Akio , Kihara Takeshi , Kawamoto Yasuhiro , Mezaki Takahiro , Hanakawa Takashi , Hashikawa Kazuo , Fukuyama Hidenao , Shibasaki Hiroshi 
Published: August 2019

ABSTRACTWe report the case of a 32‐year‐old patient who presented with catatonic stupor during the course of acute aseptic encephalitis involving the right frontotemporal area. Flumazenil‐PET performed during the stupor indicated decreased benzodiazepine receptor binding in the right frontotemporal area where glucose metabolism was preserved as revealed by FDG‐PET. An injection of diazepam immediately ameliorated catatonic symptoms and reduced widespread high amplitude slow EEG activities with right frontotemporal predominance. Compared with a SPECT study performed a week earlier, there was no abnormal right‐sided anteriorly predominant cerebral hyperperfusion after injection of diazepam. While neither flumazenil‐ nor FDG‐PET could be repeated, and with the caveat that generalized convulsions occurred initially and epilepsia partialis continua was present for two weeks starting on the 23rd day after illness onset, these findings suggest that in our case the presentation with catatonic stupor may be related to impairment of the cortical GABAergic inhibitory system.
Everyday cognition in temporal lobe and frontal lobe epilepsy
Authors: Cahn‐Weiner Deborah A. , Wittenberg Dana , McDonald Carrie 
Published: August 2019

ABSTRACTThe purpose of this pilot study was to compare the performance of patients with temporal lobe epilepsy (TLE) and frontal lobe epilepsy (FLE) on cognitively‐based daily living tasks. The hypothesis was that patients with TLE would demonstrate relatively more impairment on a test of everyday memory, while patients with FLE would demonstrate relatively more impairment on a test of everyday executive function. The five Daily Living subtests of the Neuropsychological Assessment Battery (NAB) were administered to twenty‐five patients with TLE and nine patients with FLE. The two groups were matched on all demographic variables. The hypothesis was not confirmed: the TLE and FLE patient groups did not demonstrate a double dissociation in memory and executive daily functioning. Rather, both groups were significantly impaired in daily memory functioning, while their executive daily functioning test scores were within normal limits. Relative deficits were also noted in attention in the TLE group and in language in the FLE group, suggesting that despite having focal lesions, functional impairments may be seen in a broad range of daily activities in these patient groups. Generalizability of the findings is limited due to the small number of subjects and because the everyday cognition measures employed may not have been adequately sensitive. Future studies are needed with larger sample sizes to provide a better understanding of how cognitive impairment in epilepsy is associated with deficits in daily functioning.
Predictors and prognosis of status epilepticus treated with intravenous sodium valproate
Authors: Tiamkao Somsak , Sawanyawisuth Kittisak 
Published: August 2019

ABSTRACTObjectiveTo retrospectively review the efficacy of intravenous sodium valproate (VPAiv) treatment of status epilepticus (SE) and analyse predictive factors for seizure control and death.MethodsPatients were included with a diagnosis of SE who had received intravenous sodium valproate (VPAiv) during 2005‐2007 at Srinagarind Hospital, Khon Kaen University, Thailand. Logistic regression analysis with a stepwise approach was used to evaluate the predictors of seizure control and death.ResultsThirty‐two cases were diagnosed as SE with VPAiv treatment; 12 and 20 patients received VPAiv as the first‐ and second‐line therapy, respectively. SE ceased in nine out of 12 patients (75%) and in seven out of 20 (35%) patients with VPAiv as the first‐ and second‐line therapy, respectively. No serious cardiovascular compromise was recorded. The first‐line therapy of VPAiv was the only factor that was significantly related to seizure control with an adjusted odds ratio [OR] of 5.571; 95% confidence interval [CI] of 1.128‐27.523. Initial leukocytosis and hypotension were significantly associated with death (adjusted OR: 22.765, 95% CI: 1.176‐440.640 and adjusted OR: 37.591, 95% CI: 3.035‐465.571, respectively).ConclusionFor SE patients who received VPAiv treatment, the first‐line VPAiv was effective. Initial leukocytosis and hypotension were factors that correlated with death.
Effect of methylphenidate on the quality of life in children with epilepsy and attention deficit hyperactivity disorder: an open‐label study using an osmotic‐controlled release oral delivery system
Authors: Yoo Hanik K. , Park Subin , Wang Hee‐Ryung , Lee Joong Sun , Kim Kunwoo , Paik Kyoung‐Won , Yum Mi Sun , Ko Tae‐Sung 
Published: August 2019

ABSTRACTThis open study explored whether methylphenidate could be tolerated and effective in improving the quality of life (QOL) and attention deficit hyperactivity disorder (ADHD) symptoms of children with epilepsy and ADHD. Twenty‐five subjects (aged 10.1 ± 3.0 years) with ADHD and epilepsy were recruited at an outpatient clinic in Seoul, Korea. We used the Quality of Life in Childhood Epilepsy Questionnaire (QOLCE), ADHD rating scale (ARS) and clinical global impression (CGI) in this study. Osmotic‐controlled release oral delivery system (OROS) methylphenidate, 1.0 ± 0.4 mg/kg/day, was administered for 55.2 ± 7.5 days. The QOL subscales including physical restriction (p = 0.005), self‐esteem (p = 0.002), memory (p < 0.001), language (p = 0.005), other cognition (p < 0.001), social interaction (p = 0.002), behaviour (p < 0.001), general health (p = 0.002) and QOL (p < 0.001) were significantly increased and the ARS (p < 0.001) and CGI‐Severity of illness scores (p < 0.001) were significantly reduced after medication. Although 60% of subjects had experienced adverse effects, most were tolerable and only two subjects withdrew from the study owing to unbearable adverse effects (anorexia and insomnia). Two subjects had seizure attacks during the study period without having to discontinue the trial drug. Despite limitations related to the small sample size and the open design of the present pilot study, our results suggest that OROS methylphenidate may be well tolerated and effective in reducing ADHD symptoms and improving QOL in this patient population.