bluuebunny/crossref_metadata_2025_split huggingface dataset:
Quelle place pour la musicothérapie au sein de l’Éducation nationale ?
Authors: Girardot Andrea , Bostnavaron Clémence 
Published: November 2024

Soumission à Epi-revel
This article focuses on the development of a new music therapy’s protocol that the author has implemented as part of an association of people suffering from eating disorders. It is a creative process where the patient is invited, step by step, to develop a sound canvas of their own based on their sound identity. It is a method that makes the sounds tangible and palpable where we explore the creativity of each individual through the potential of which, it helps the better being and therapeutic awareness.
Cet article porte sur le développement d’un nouveau protocole de musicothérapie que l’auteure a mis en application dans le cadre d’une association de personnes souffrants de trouble de conduites alimentaires. Il s’agit d’un processus créatif où le patient est invité, étape par étape, à élaborer une toile sonore qui lui est propre en se basant sur son identité sonore. C’est une méthode qui rend les sons concrets et palpables où l’on explore la créativité de chaque individu à travers le potentiel de laquelle, celle-ci aide au mieux être et à des prises de consciences thérapeutiques.
National audience
Musicothérapie et pluridisciplinarité, de l'indication à la place
Authors: Fillias Alice , Donini Violetta , Miller Alice 
Published: November 2024

Soumission à Epi-revel
International audience
La musicothérapie donne souvent lieu à des groupes thérapeutiques mais la littérature recense peu de références en lien avec un travail pluridisciplinaire en CMPP. Ainsi, nous vous présenterons trois exemples de co-thérapies associant la psychologie, la psychomotricité et l'orthophonie à la musicothérapie. À travers ce travail multidisciplinaire nous explorerons la question de l'indication à celle de la place. Pour cela, cet article propose d'abord « l'avant » d'un groupe de communication sonore en présentant les bilans psychologique et psychomusical, puis les questions sous-tendues lors d'un groupe musicothérapie-psychomotricité qui aborde le « pendant » de la séance et enfin, l'analyse à posteriori du groupe associant l'orthophonie et musicothérapie c'est-à-dire « l'après ». Le fonctionnement institutionnel et la co-thérapie sont abordés à travers nos observations cliniques, avec pour résultat une mise en perspective de la place de la musicothérapie au CMPP et du traitement de la question du sonore et du langage dans chacun de ces groupes.
Pluridisciplinary groups using music therapy are frequent however there are few scholarly works referring to this type of therapy in a CMPP (Centre Medico Psycho Pedagogique). This article presents three examples of co-therapy associating psychology, psycho-motor therapy and speech therapy with music therapy. This pluridisciplinary approach focuses on the question of therapeutic indication and the role of patients and therapists within the session. In order to explore these elements, this article first proposes a comparison of clinical situations that emerged during the construction of a sound-based communication group. Second, we explore the questions that arose during a psychomotor-music therapy group, and third, the analysis in the aftermath of a group led by a speech therapist and a music therapist. Through our clinical observations, we look at how music therapy exists in an institution such as a CMPP and explore the questions of sound and language in each of the pluridisciplinary groups.
Making European Cities more Affordable, Productive and Sustainable
Authors: Carbonaro Gianni , Leanza Eugenio 
Published: November 2024

Soumission à Epi-revel
In this article we take inspiration from the experience of the JESSICA Initiative to delineate the rationale for a city-based, bottom-up approach to stimulate the economic recovery of the European Union. The proposed approach involves an agenda for a European research programme on urban management and finance, which brings together the vision of the city as a system of interlinked assets to be managed in a sustainable way and the use, in this context, of a methodology broadly inspired to corporate finance principles. The proposed agenda is intended to lead to better diagnostics and strategic investing to address urban transformation patterns likely to characterise the European city system in the coming years. This agenda should stimulate European researchers and practitioners to develop a methodology leading to the definition of sustainable productivity metrics for urban systems, as well as practical modelling strategies that can assist the decisions of city managers and long-term investors in urban infrastructure.
International audience
Territorial policies for industrial renaissance and innovation
Authors: Bellandi Marco 
Published: November 2024

Soumission à Epi-revel
Industrial districts, cities, and other local reproductive systems should be considered still as a fundamental structure of multiscale policies of industrial development in contemporary Italy. However the challenges brought about by the present phase of globalization, multiplied by the effects of the last international economic crisis and the following recession, give to the prospects of industrial development a more dramatic meaning, which is referred here as the need of industrial renaissance. Discontinuities in local innovation and internationalization processes should be managed, and new and traditional production systems helped to find a lease of good life in Italy. In this context the local level of the industrial economies and policies, though fundamental, becomes clearly more dependent on processes which take place on larger territorial scales. The paper tries to illustrate what are some of the requisites for effective combinations of different scales of industrial processes and policies in contemporary Italy, focussing in particular to the national level.
International audience
Structural insights into interactions between viral suppressor of RNA silencing protein p19 mutants and small RNAs
Authors: Foss Dana V. , Schirle Nicole T. , MacRae Ian J. , Pezacki John Paul 
Published: April 2019

Viral suppressors of RNA silencing (VSRSs) are a diverse group of viral proteins that have evolved to disrupt eukaryotic RNA silencing pathways, thereby contributing to viral pathogenicity. The p19 protein is a VSRS that selectively binds to short interfering RNAs (siRNAs) over microRNAs (miRNAs). Mutational analysis has identified single amino acid substitutions that reverse this selectivity through new high‐affinity interactions with human miR‐122. Herein, we report crystal structures of complexed p19‐T111S (2.6 Å), p19‐T111H (2.3 Å) and wild‐type p19 protein (2.2 Å) from the Carnation Italian ringspot virus with small interfering RNA (siRNA) ligands. Structural comparisons reveal that these mutations do not lead to major changes in p19 architecture, but instead promote subtle rearrangement of residues and solvent molecules along the p19 midline. These observations suggest p19 uses many small interactions to distinguish siRNAs from miRNAs and perturbing these interactions can create p19 variants with novel RNA‐recognition properties.DatabaseModel data are deposited in the PDB database under the accession numbers 6BJG, 6BJH and 6BJV.
Method for the determination of carbon monoxide in workplace air using a Fourier‐transform infrared spectrometer (FTIR spectrometer) [Air Monitoring Methods, 2019]
Authors: Gluschko A. , Befurt R. , Brock T.H. , Hebisch R. , Hartwig A. ,   MAK Commission
Published: April 2019

Abstract
This analytical method is a validated measurement procedure for the determination of carbon monoxide in workplace air. The sampling is performed stationary. In the measurement procedure the concentration of carbon monoxide is measured continuously and recorded directly. The sample flow rate is set to max 2.0 L/min. The detector records an interferogram, from which the absorption spectrum is obtained by means of an internal Fourier transform calculation. The signal patterns in the IR spectrum are compared, and the concentrations of carbon monoxide in workplace air are determined. This method is suitable for measurement at the workplace over longer time periods as well as for short‐term measurement. It is also possible to read the current CO concentration at any time. The limit of quantification is 0.29 ppm and the limit of detection is 0.09 ppm for a measurement period of one minute. For a measurement period of 20 seconds a limit of quantification of 0.41 ppm and a limit of detection of 0.12 ppm were obtained.
Joint Publication of the Analytical Subcommittee of the Chemistry Board of Experts of the Expert Committee Raw Materials and Chemical Industry of the German Social Accident Insurance and the working group “Air Analyses” of the Permanent Senate Commission of the Deutsche Forschungsgemeinschaft for the Investigation of Health Hazards of Chemical Compounds in the Work Area.
Magnesium oxide, insoluble (Sintermagnesite) (respirable fraction) [MAK Value Documentation, 2018]
Authors: Hartwig A. ,   MAK Commission
Published: April 2019

Abstract

The German Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area has reevaluated magnesium oxide. Magnesium oxide, sintermagnesite [
1309‐48‐4
], is a biopersistent granular dust. Therefore, the respirable fraction of magnesium oxide dust has been classified in Carcinogen Category 4 and a MAK value of 0.3 mg/m
3
× material density was established for the respirable fraction in analogy to the other biopersistent granular dusts. Additionally for this fraction the Peak Limitation Category II with an excursion factor of 8 was established. Since magnesium oxide is not systemically distributed and accumulates only locally in the lungs, no developmental effects due to this dust are expected to occur at the MAK value of 0.3 mg/m
3
× material density (respirable, R‐fraction). Magnesium oxide has accordingly been classified in Pregnancy Risk Group C. Magnesium oxide is not designated with either “Sa” or “Sh” or “H”.
1,1,1‐Trichlorethan [MAK Value Documentation in German language, 2019]
Authors: Hartwig A. ,   MAK Commission
Published: April 2019

Abstract

The German Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area has re‐evaluated the maximum concentration at the workplace (MAK value) and the Pregnancy Risk Group of 1,1,1‐trichloroethane [
71‐55‐6
].

Critical are pre‐narcotic effects observed in male volunteers exposed at rest to 350 ml/m
3
. The MAK value has now been lowered to 100 ml/m
3
taking into account the increased respiratory volume at the workplace because the blood:air partition coefficient of 1,1,1‐trichlorethane is > 5 (see List of MAK and BAT Values, Section I b and I c). As a systemic effect is critical, Peak Limitation Category II is retained. To avoid short‐term pre‐narcotic effects, the excursion factor of 1 is also retained.

The differences between the MAK value and the NOAECs for developmental toxicity in rats, rabbits and mice are sufficient even taking into account the increased respiratory volume at the workplace. Therefore, damage to the embryo or foetus is unlikely when the MAK value is not exceeded and 1,1,1‐trichloroethane remains assigned to Pregnancy Risk Group C.
1,1,1‐Trichloroethane is neither carcinogenic in rats or mice nor a germ cell mutagen. The designation with “H” (for substances that can be absorbed via the skin in toxicologically relevant amounts) is retained. There are no data on the sensitizing potential in humans. 1,1,1‐Trichloroethane is not a skin sensitizer in guinea pigs.
α‐Aluminiumoxid (α‐Al2O3),Korund (alveolengängige Fraktion) [MAK Value Documentation in German language, 2019]
Authors: Hartwig A. ,   MAK Commission
Published: April 2019

AbstractThe German Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area has re‐evaluated α‐aluminium oxide [1344‐28‐1]. α‐Aluminium oxide is a biopersistent granular dust. There are no inhalation studies from which a NOAEC could be derived. Therefore, the respirable fraction of α‐aluminium oxide dust is classified in Carcinogen Category 4 and a maximum concentration at the workplace (MAK value) of 0.3 mg/m3× material density is established for the respirable fraction by analogy with the other biopersistent granular dusts (GBS). As workers are generally exposed to several aluminium species at the workplace, it is recommended that the biological tolerance value (BAT value) for aluminium is also observed. The classification in Carcinogen Category 4 is based on data that showed increased tumour incidences in rats exposed to biopersistent granular dusts in the high dose range. These tumours are regarded as a consequence of the inflammatory mechanism of action, for which a threshold can be defined. Direct genotoxic effects appear to be of subordinate relevance for the carcinogenicity of biopersistent granular dusts. By analogy with biopersistent granular dusts, Peak Limitation Category II is established for α‐aluminium oxide with an excursion factor of 8. Since α‐aluminium oxide is not systemically distributed and accumulates only locally in the lungs, damage to the embryo or foetus is unlikely when the MAK value or the BAT value is not exceeded. α‐Aluminium oxide is classified accordingly in Pregnancy Risk Group C. α‐Aluminium oxide is not expected to be a sensitizer and is not taken up via the skin in toxicologically relevant amounts.
Nanometer Resolved Real Time Visualization of Acidification and Material Breakdown in Confinement
Authors: Merola Claudia , Cheng Hsiu‐Wei , Dworschak Dominik , Ku Ching‐Shun , Chiang Ching‐Yu , Renner Frank Uwe , Valtiner Markus 
Published: April 2019

AbstractLocalized surface reactions in confinement are inherently difficult to visualize in real‐time. Herein multiple‐beam‐interferometry (MBI) is extended as a real‐time monitoring tool for corrosion of nanometer confined bulk metallic surfaces. The capabilities of MBI are demonstrated, and the initial crevice corrosion mechanism on confined nickel and a Ni75Cr16Fe9 model material is compared. The initiation of crevice corrosion is visualized in real time during linear sweep polarization in a 1 × 10−3 m NaCl solution. Pre‐ and post‐experiment analysis is performed to complementarily characterize the degraded area with atomic force microscopy (AFM), optical microscopy, nano‐Laue diffraction (nano‐LD), scanning electron microscopy (SEM)/electron backscatter diffraction (EBSD), and X‐ray photoelectron spectroscopy (XPS). Overall, Ni75Cr16Fe9 displays a better corrosion resistance; however, MBI imaging reveals 200 nm deep severe localized corrosion of the alloy in the crevice opening. Chromium rich passive films formed on the alloy contribute to accelerated corrosion of the confined alloy by a strongly acidifying dissolution of the passive film in the crevice opening. Nano‐LD further reveals preferential crystallographic defect and corrosion migration planes during corrosion. MBI provides nanometer accurate characterization of topologies and degradation in confined spaces. The technique enables the understanding of the initial crevice corrosion mechanism and testing modeling approaches and machine‐learning algorithms.
The Role of Ordering on the Thermoelectric Properties of Blends of Regioregular and Regiorandom Poly(3‐hexylthiophene)
Authors: Lim Eunhee , Glaudell Anne M. , Miller Rachel , Chabinyc Michael L. 
Published: April 2019

AbstractThe thermoelectric properties of semiconducting polymers are influenced by both the carrier concentration and the morphology that sets the pathways for charge transport. A combination of optical, morphological, and electrical characterization is used to assess the effect of the role of disorder on the thermoelectric properties of thin films of poly(3‐hexylthiophene) (P3HT) doped with 2,3,5,6‐tetrafluoro‐7,7,8,8‐tetracyanoquinodimethane (F4TCNQ). Controlled morphologies are formed by casting blends of regioregular (RR‐P3HT) and regiorandom (RRa‐P3HT) and then subsequently doped with F4TCNQ from the vapor phase. Optical spectroscopy and X‐ray scattering show that vapor phase doping induces order in the disordered regions of thin films and increases the long‐range connectivity of the film. The thermoelectric properties are assessed as a function of composition and it is shown that while the Seebeck coefficient is affected by structural ordering, the electrical conductivity and power factor are more strongly correlated with the long‐range connectivity of ordered domains.
Asymmetric Direct Remote Michael Addition Reactions of Allyl Furfurals via Dearomative Trienamine and Tetraenamine Catalysis
Authors: Xu Chang‐Jiang , Li Hong‐Wei , He Xiao‐Long , Du Wei , Chen Ying‐Chun 
Published: April 2019

Abstract2‐Allyl‐3‐furfural could generate dearomative trienamine species in the presence of a chiral secondary amine, and underwent an asymmetric remote ϵ‐regioselective Michael addition reaction with isatin‐derived α,α‐dicyanoalkenes. Meanwhile, the more challenging dearomative tetraenamine intermediate from 5‐allyl‐2‐furfural could be similarly utilized in very remote η‐regioselective Michael additions. In general, good yields with moderate to high enantioselectivity were obtained by employing a concerted activation strategy of bifunctional secondary amine/thiourea catalysts.
Improved oxidative biostability of porous shape memory polymers by substituting triethanolamine for glycerol
Authors: Weems Andrew C. , Wacker Kevin T. , Maitland Duncan J. 
Published: April 2019

ABSTRACTWhile many aromatic polyurethane systems suffer from poor hydrolytic stability, more recently proposed aliphatic systems are oxidatively labile. The use of the renewable monomer glycerol as a more oxidatively resistant moiety for inclusion in shape memory polymers (SMPs) is demonstrated here. Glycerol‐containing SMPs and the amino alcohol control compositions are compared, with accelerated degradation testing displaying increased stability (time to complete mass loss) as a result of the inclusion of glycerol without sacrificing the shape memory, thermal transitions, or the ultralow density achieved with the control compositions. Gravimetric analysis in accelerated oxidative solution indicates that the control will undergo complete mass loss by approximately 18 days, while lower concentrations of glycerol will degrade fully by 30 days and higher concentrations will possess approximately 40% mass at the same time. In real‐time degradation analysis, high concentrations of glycerol SMPs have 96% mass remaining at 8 months with 88% gel fraction remaining that that time, compared to less than 50% mass for the control samples with 5% gelation. Mechanically, low glycerol‐containing SMPs were not robust enough for testing at three months, while high glycerol concentrations displayed increased elastic moduli (133% of virgin materials) and 18% decreased strain to failure. The role of the secondary alcohol, as well as isocyanates, is presented as being a crucial component in controlling degradation; a free secondary alcohol can more rapidly undergo oxidation or dehydration to ultimately yield carboxylic acids, aldehydes, carbon dioxide, and alkenes. Understanding these pathways will improve the utility of medical devices through more precise control of property loss and patient risk management through reduced degradation. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 47857.
Manipulating drug release from tridimensional porous substrates coated by initiated chemical vapor deposition
Authors: Ghasemi‐Mobarakeh Laleh , Werzer Oliver , Keimel Roman , Kolahreez Davood , Hadley Peter , Coclite Anna Maria 
Published: April 2019

ABSTRACTIn the recent years, modern wound dressings have attracted much interest to accelerate wound healing processes with the topical delivery of drugs directly on wounds having a significant effect on wound rehabilitation. The objective of this study was to develop a model dressing that would not only provide wound protection from the environment but might also provide the possibility to keep it moist and deliver a drug for potential speeding the healing process. Poly(ethylene terephthalate), cotton fabrics, and polycaprolactone (PCL) nanofibers were used as different tridimensional porous substrates, loaded with a model drug, clotrimazole. The results show that the chemical structure and surface area to volume ratio of the pristine substrates affect the drug release profile. Coating of such substrates by hydrogels poly(2‐hydroxyethyl methacrylate) (p‐HEMA) and poly(methacrylic acid) (p‐MAA) was successfully achieved by initiated chemical vapor deposition. This method was chosen because it is gentle and solventless and most important it can coat free areas within the three‐dimensional structures. Scanning electron microscopy results revealed that p‐HEMA and p‐MAA conformally coated the fibers of the substrates. Moreover, drug release experiments showed that p‐HEMA and p‐MAA coatings provide barriers preventing sudden drug release. In conclusion, our results indicated the possibility of fabricating dressings containing a drug with tunable drug release profile depending on several parameters even though a strong porous structure exists. © 2019 The Authors. Journal of Applied Polymer Science published by Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 47858.
Insight into the rheological behaviors of a polyanionic collagen fabricated with poly(γ‐glutamic acid)‐NHS ester
Authors: Ding Cuicui , Yang Junhui , Lan Fei , Zheng Zhigong , Dai Libo , Zhang Min 
Published: April 2019

AbstractThe rheological behaviors of a polyanionic collagen, fabricated using poly(γ‐glutamic acid)‐N‐hydroxysuccinimide (γ‐PGA‐NHS) as a novel modifier, were investigated in this study. It was found that both of the native and modified collagen solutions were pseudoplastic fluids, as shown from the steady‐shear tests. While the storage modulus and loss modulus of collagen increased with increasing the amount of γ‐PGA‐NHS, or with increasing the degree of esterification of γ‐PGA‐NHS; meanwhile, the dynamic denaturation temperature determined by dynamic temperature sweep was also increased, indicating an improved thermal stability of collagen solution modified by γ‐PGA‐NHS. The creep–recovery measurements showed that the resistance to deformation was enhanced for modified collagen, probably due to the cross‐linking occurred between the ε‐amino groups of collagen molecules and α‐COOH groups of γ‐PGA‐NHS, as well as the electrostatic interaction and hydrogen‐bond interactions between the two molecules. Furthermore, the aggregation of collagen fibers was promoted due to these interactions between collagen and γ‐PGA‐NHS as observed by atomic force morphology. In addition, the modified collagen exhibited good cytocompatibility as demonstrated by cell growth culturing. The obtained information was expected to give valuable clues to the design and fabrication of controlled stable collagen‐based products for applications in various biomedical fields.