bluuebunny/crossref_metadata_2025_split huggingface dataset:
Vector analysis of steerable mechanical tension across nuclear lamina
Authors: Chen TingTing , Wu HuiWen , Wang YuXuan , Shan JinJun , Zhang JiaRui , Zhao HuanHuan , Guo Jun 
Published: November 2018

SUMMARYThe nucleus is the most prominent organelle in eukaryotic cells, and its deformation depends on interactions between the nuclear lamina (NL) and cytoskeleton structural tensions. The structural tensions can be quantified at a pico-Newton (pN) level using a genetically encoded optical probe. In living cells, NL tensions countered the 4.26pN resting strain imposed competitively by cytoskeletal tension. The depolymerization of microfilaments or microtubules drove an aberrant increase in outward osmotic pressure through the production of mass protein-nanoparticles. The osmotic pressure also served as a directional converter of inward cytoskeletal force, and contributed to the outward expansion of NL via the passive pull of intermediate filaments (IFs). The NL, but not IFs, can remotely detect extracellular osmosis pressure alterations, which are closely associated with highly polarized microfilament and microtubule structures and their directional force activities. The oxidative-induced increase of NL tension results from intracellular hyper-osmosis, associated closely with protein-nanoparticles production elicited by cofilin and stathmin activation. These data reveal that intracellular steerable forces interact direction-dependently to control NL tension in terms of their magnitude and vectors.
Improving equality in healthcare for people with learning disabilities: a joint working approach between housing and hospital
Authors: Owen Alice 
Published: November 2018

Purpose
The current project aims to draft an NHS and care provider joint working protocol for patients with learning disabilities as they transition between care and NHS hospital services. The purpose of this paper is to present the rationale behind a joint working protocol and the progress of the project to date.

Design/methodology/approach
Working in partnership, Basildon University Hospital and Estuary Housing Association have sought to investigate the experiences in hospital of the people they support with learning disabilities. This has involved ongoing work examining patient pathways from both a hospital and care provider perspective as well as engaging in discussions with key stakeholders. It is hoped that these insights will feed into recommendations to form the joint working protocol.

Findings
Current findings are limited as this paper presents an interim report on an ongoing project. Initial findings around positive joint working practices are detailed. An emerging recommendation around improved information sharing between health and care provider in acute hospital settings is also discussed.

Originality/value
It is hoped that the project will improve experiences of people with learning disabilities in hospital locally, while inspiring other hospitals and care providers to adopt a joint working approach at a wider level.
Are benefits of others important? The interaction effect of moral identity and construal level on green consumption
Authors: Wu Bo , Li Dongjin , Zhang Chubing 
Published: November 2018

Purpose
The purpose of this paper is to examine the interaction effect of moral identity and construal level on consumer green consumption and the mediating role of pro-environmental self-accountability.

Design/methodology/approach
The authors examined the hypotheses in two experiment studies. In study 1, the authors measured participants’ chronic individual difference of moral identity and primed construal level. In study 2, the authors primed moral identity and measured chronic individual difference of construal level. The authors also measured pro-environmental self-accountability in these two studies.

Findings
The results reveal that construal level moderates the relationship between moral identity and consumer green consumption, specifically, when consumers are induced a high construal level, moral identity has no effect on consumer green consumption, while when consumers are induced a low construal level, moral identity has a positive effect on consumer green consumption; the interaction of moral identity and construal level on green consumption is mediated by pro-environmental self-accountability.

Research limitations/implications
This research enriches the literature on how to improve consumer green consumption, and thus has some managerial and public policy implications. But the authors only chose students as participants and the dependent measures are also limited. Future research can choose other type of sample and other dependent measures to test the generalization of the conclusion.

Originality/value
Prior literature of green consumption lacks research on mediation mechanism. Due to prior literature gaps, the authors integrate social-cognitive perspective moral identity theory, especially the in-group circle expansion of moral identity, and construal level theory to investigate the moderating effect of construal level on the relationship between moral identity and green consumption and the mediation effect of pro-environmental self-accountability.
Interorganizational network on top management team – entry mode choice relationship
Authors: Mukherjee Subhasree , Dhayanithy Deepak 
Published: November 2018

PurposeBy applying upper echelons perspective to the choice of full or shared control entry modes, this study aims to explore the moderating effect of interorganizational network on the top management team (TMT) characteristics and entry mode choice relationship. Existing studies on TMT’s demographic characters’ influence on entry mode choice remains inconclusive. The implicit assumption in extant literature is that firms share similar network structural advantages. This study integrates the largely ignored, network structural concept with entry mode to show how firm-level decisions are the outcome of interaction between internal and external environment.Design/methodology/approachThe interorganizational network is modeled using board interlock data. The moderating effect of network is modeled on network size, centrality of the firms and density of ties, considering tenure and international experience of the upper echelons. The hypotheses are tested based on a sample of 83 publicly listed Indian firms from 2012 to 2015.FindingsThe findings indicate that despite a high international experienced TMT’s preference of full control entry mode, the high central position of the firm can influence the decision against full control entry modes. However, the choice of full control entry mode is also enhanced by the density of firm’s network. Similar evidence is also observed with tenure variable as well where the moderating variables showed a trend toward influencing the entry mode choices.Originality/valueThus, this study attempted to reconcile the inconsistencies prevalent in the relationship between TMT variables and choice of entry mode by introducing the contextual factor of interorganizational networks.
Investor sentiment antecedents
Authors: Dasgupta Ranjan , Singh Rashmi 
Published: November 2018

PurposeThe determinants of investor sentiment based on stock market proxies are found in numbers in empirical studies. However, investor sentiment antecedents developed from primary survey measures by constructing an investor sentiment index (ISI) are not done till date. The purpose of this paper is to fill this research gap by first developing an ISI for the Indian retail investors and then examining the investor-specific, stock market-specific, macroeconomic and policy-specific factors’ individual impact on the investor sentiment.Design/methodology/approachFirst, the authors develop the ISI by using the mean scores of six statements as formulated based on popular direct investor sentiment surveys undertaken throughout the world. Then, the authors employ the structural equation modeling approach on the responses of 576 respondents on 40 statements (representing the index and four study hypotheses) collected in 2016 across the country.FindingsThe results show that investor- and stock market-specific factors are the major antecedents of investor sentiment for these investors. However, interestingly macroeconomic fundamentals and policy-specific factors have no role to play in driving their sentiment to invest in the stock market.Practical implicationsThe major implication of the results is that the Indian retail investors are showing a mixed approach of Bayesian and behavioral finance decision making. So, these implications can guide the investment consultants, regulators, other stakeholders in markets and overwhelmingly the retail investors to introspect their investment decision making across time horizons.Originality/valueThe formulation of ISI in an emerging market context and thereafter examining possible antecedents to influence retail investors in their investment decision making are not done till date. So, the study is unique in its research issue and findings and will have significant implication for the retail investors at least in emerging market contexts.
Inhibition of cancer stem cells promoted by Pimozide
Authors: Gonçalves Jussara Maria , Silva Carolina Amália Barcellos , Rivero Elena Riet Correa , Cordeiro Mabel Mariela Rodríguez 
Published: November 2018

SummaryOver the past years, studies have described that users of antipsychotics are less likely to develop cancer than the population in general due to cytotoxic properties of this class of drugs on cancer cells. For this reason, Pimozide has been widely studied as a potential anticancer treatment, and satisfactory results in melanoma, central nervous system tumours, osteosarcoma, neuroblastoma, myeloproliferative neoplasms, breast, lung, prostate, ovarian, colorectal, pancreatic, and hepatocellular carcinoma have been showed. Moreover, advantages as clinical use approved by the Food and Drug Administration (FDA), high clinical safety, low side effects, and reasonable price have stimulated the treatment with Pimozide instead of other agents. The action mechanism remains unclear, but three vias associated to cancer stem cell (CSC) hypothesis show that Pimozide: (a) blocks CSC features, as epithelial‐to‐mesenchymal transition (EMT), through inhibition of Wnt‐β/catenin signalling; (b) acts as an inhibitor of signal transducer and activator of transcription (STAT‐3 and 5), pathway which is activated and up‐regulated in CSCs; (c) inhibits ubiquitine specific protease (USP1) and WD repeat‐containing protein 48 (WDR48), that are proteins responsible to inhibit the differentiation and to maintain the cell in an undifferentiated state. Based on this perspective, the aim of this manuscript is to review the antineoplastic role of Pimozide during tumorigenesis and its potential to revert the process of undifferentiation and proliferation of CSC through different vias.
A multisystem composite biomarker as a preliminary diagnostic test in bipolar disorder
Authors: Munkholm K. , Vinberg M. , Pedersen B. K. , Poulsen H. E. , Ekstrøm C. T. , Kessing L. V. 
Published: November 2018

ObjectiveDiagnosis and management of bipolar disorder (BD) are limited by the absence of available laboratory tests. We aimed to combine data from different molecular levels and tissues into a composite diagnostic and state biomarker.MethodsExpression levels of 19 candidate genes in peripheral blood, plasma levels of BDNF, NT‐3, IL‐6 and IL‐18, leukocyte counts, and urinary markers of oxidative damage to DNA and RNA were measured in 37 adult rapid‐cycling patients with BD in different affective states during a 6‐ to 12‐month period and in 40 age‐ and gender‐matched healthy individuals in a longitudinal, repeated measures design comprising a total of 211 samples. A composite biomarker was constructed using data‐driven variable selection.ResultsThe composite biomarker discriminated between patients with BD and healthy control individuals with an area under the receiver operating characteristic curve (AUC) of 0.83 and a sensitivity of 73% and specificity of 71% corresponding with a moderately accurate test. Discrimination between manic and depressive states had a moderate accuracy, with an AUC of 0.82 and a sensitivity of 92% and a specificity of 40%.ConclusionCombining individual biomarkers across tissues and molecular systems could be a promising avenue for research in biomarker models in BD.
Click chemistry‐based synthesis and cytotoxic activity evaluation of 4α‐triazole acetate podophyllotoxin derivatives
Authors: Hou Wei , Zhang Guanjun , Luo Zhi , Su Lin , Xu Hongtao 
Published: November 2018

AbstractA series of novel 4α‐triazole acetate podophyllotoxin derivatives were synthesized via click chemistry. In vitro cytotoxic activity evaluation showed that most of the derivatives exhibited potent inhibitory activities against the tested cancer cell lines with low nanomolar IC50 values. Further studies demonstrated that compound 31 exhibited broad‐spectrum cytotoxic activities, effectively overcame drug‐resistance, and showed relatively weak cytotoxicity on non‐cancer cells. Preliminary mechanistic studies indicated that 31 might have action on microtubule, cause cell cycle arrest at G2/M phase, and induce apoptosis in human PC‐3 cancer cells.
Blocking antibodies induced by peanut oral and sublingual immunotherapy suppress basophil activation and are associated with sustained unresponsiveness
Authors: Orgel Kelly , Burk Caitlin , Smeekens Johanna , Suber Jada , Hardy Lakeya , Guo Rishu , Burks A. Wesley , Kulis Michael 
Published: November 2018

AbstractBackgroundOral and sublingual immunotherapies for peanut allergy have demonstrated efficacy in small clinical trials; however, mechanisms and biomarkers correlating with clinical outcomes remain elusive. Previous studies have demonstrated a role for IgG in post‐OIT plasma in the suppression of IgE‐mediated mast cell reactions.ObjectiveThe aim of this study was to characterize the role that peanut oral and sublingual immunotherapy‐induced plasma factors play in the inhibition of ex vivo basophil activation and whether inhibitory activity is associated with clinical outcomes.MethodsPlasma samples from subjects on placebo, peanut oral immunotherapy (OIT) or peanut sublingual immunotherapy (SLIT), and IgG‐depleted plasma or the IgG fraction were incubated with sensitized basophils, and the inhibition of basophil activation following stimulation with peanut extract was measured. Basophil inhibition results were compared between the two routes of immunotherapy, time on treatment and clinical outcomes.ResultsPlasma from subjects after 12 months of active peanut OIT, but not placebo, inhibits basophil activation ex vivo. Depletion of IgG abrogated the blocking effect of OIT plasma, while the IgG fraction substantially blocked basophil activation. Basophils are inhibited to a similar extent by undiluted OIT and SLIT plasma; however, diluted OIT plasma from the time of desensitization challenge inhibited basophils more than diluted SLIT plasma from time of desensitization challenge. Plasma from subjects who experienced sustained unresponsiveness following OIT inhibited basophils to a greater extent than plasma from subjects who were desensitized, but this was not true for SLIT.Conclusions and Clinical RelevancePeanut immunotherapy induces IgG‐dependent functional changes in plasma that are associated with OIT but not SLIT clinical outcomes. Understanding the mechanisms of peanut OIT and SLIT may help derive informative biomarkers.
Ascorbic acid supplementation improves postprandial glycaemic control and blood pressure in individuals with type 2 diabetes: Findings of a randomized cross‐over trial
Authors: Mason Shaun A. , Rasmussen Bodil , van Loon Luc J.C. , Salmon Jo , Wadley Glenn D. 
Published: November 2018

AimThe primary aim of this study was to investigate whether ascorbic acid (AA) supplementation improves postprandial glucose responses under free‐living conditions in individuals with type 2 diabetes. A secondary aim was to investigate the effect of AA supplementation on blood pressure.Materials and methodsA total of 31 individuals with type 2 diabetes (26 males and 5 females; aged 61.8 ± 6.8 years; duration of diabetes, 5.6 ± 4.6 years; HbA1c, 7.6% ± 0.7% [mean ± SD]) were enrolled in a randomized cross‐over study involving 4 months of supplementation with oral AA (2 × 500 mg/d) or placebo. Participants wore continuous glucose monitors for 48 hours and consumed standardized meals pre‐ and post‐supplementation. Measurements included postprandial glucose incremental areas under the curve (iAUC), duration of day in hyper‐ and hypo‐glycaemia status, average 24‐hour and daily postprandial glucose concentrations, HbA1c, insulin, blood pressure (BP) and oxidative stress (F2‐isoprostanes).ResultsFollowing AA supplementation, significant decreases were observed in daily postprandial glucose iAUC (−36%), in duration of day with hyperglycaemia (−2.8 h/d) and postprandial hyperglycaemia (−1.7 h/d), in average 24‐hour glucose (−0.8 mmol/L) and daily postprandial glucose (−1.1 mmol/L) concentrations, in systolic (−7 mm Hg) and diastolic (−5 mm Hg) blood pressures and in a specific fraction of free plasma F2‐isoprostanes (−47 pg/mL) as compared to placebo.ConclusionsIndividuals with type 2 diabetes experienced improved postprandial and 24‐hour glycaemia and decreased BP after 4 months of AA supplementation as compared to placebo. These findings offer evidence for the proposed use of AA as an adjunct therapy to improve glycaemic and BP control in individuals with type 2 diabetes.
Comparison of student’s perceptions between 3D printed models versus series models in paediatric dentistry hands‐on session
Authors: Marty Mathieu , Broutin Alice , Vergnes Jean‐Noel , Vaysse Frédéric 
Published: November 2018

AbstractIntroductionDental education emphasises the acquisition of technical skills. Recent advances in 3D printing technologies have enabled the emergence of new educational tools usable in hands‐on work sessions. The possibility to print 3D models from CT scans of patients is now available to dental practitioners. The aim of this study was to develop and evaluate a 3D printed model for paediatric dentistry training and compare it to the reference model used in our faculty.Materials and Method3D models were obtained by modifying and printing the CT scan of a young patient using the Voco® Solflex 350 3D® printer and Voco® V‐print resin. Thirty‐four students were asked to perform a pulpotomy and preparation for a stainless steel paediatric crown on tooth 85 on both the 3D printed model and the industrial model (Frasaco®), and then to answer a questionnaire. The data were analysed using R software.ResultBoth models obtained high scores. The learning potential and its applicability to clinical practice showed no statistically significant difference. Although the colour and the simulation of the proximal area disturbed the students (P = 0.009), the 3D models were seen as a good idea (P = 0.012). When it came to model design, the students appreciated the simulation of caries on 3D models (P = 0.0001) and considered the use 3D of models as a more realistic experience (P = 0.017).DiscussionAlthough this study has some limitations (number of participants, choice of the models to be compared), it constitutes the first attempt to compare students’ perception of 3D and series models. It shows that 3D technology makes it possible to obtain models of similar quality while offering a more realistic experience.ConclusionThere are still many ways in which these models could be improved. For example, modifying the quality of resins could improve the milling sensation, and the design could be improved to achieve better contact points. Nevertheless, these 3D models offer the possibility to give the patient a more central place in the education of future practitioners.
Childhood social, emotional, and behavioural problems and their association with behaviour in the dental setting
Authors: Cademartori Mariana G. , Corrêa Marcos B. , Silva Ricardo A. , Goettems Marília L. 
Published: November 2018

AbstractBackgroundMental disorders are among the main causes of global disability in children, with negative impacts on their quality of life. It is possible that mental disorders could be associated with how children react in the dental setting.AimTo test the association between children's psychological attributes and behaviour presented during dental care.DesignA questionnaire was given to mothers of children attending a paediatric dental clinic. Psychological attributes were evaluated using the Strengths and Difficulties Questionnaire. For analysis, the Internalizing and Externalizing problems and the Prosocial behaviour subscales were considered. Children's behaviour was assessed using the Frankl Scale. For analysis, Poisson regression models were employed. A significant level of P ≤ 0.05 was adopted.ResultsOverall, 128 children aged between four and 12 years were included. Total difficulties (PR 5.36; 95%CI 2.2‐12.9), Internalizing problems (PR 4.04; 95%CI 1.6‐10.0), and externalizing problems (PR 3.36; 1.5‐7.7) were associated with uncooperative behaviour. In relation to the strength domain, the Prosocial behaviour subscale (PR 1.21; 95%CI 0.6‐2.6) was not associated with child behaviour.ConclusionsThis study provides evidence that children aged between four and 12 years with internalizing and externalizing problems tend to have a higher prevalence of negative behaviour during dental treatment.
It’s security, stupid! Voters’ perceptions of immigrants as a security risk predicted support for Donald Trump in the 2016 US presidential election
Authors: Wright Joshua D. , Esses Victoria M. 
Published: November 2018

AbstractWe analyzed two datasets to determine the predictive validity of four explanations of support for Donald Trump during the 2016 US presidential election: (a) security concerns regarding immigrants, (b) economic concerns regarding immigrants, (c) cultural concerns regarding immigrants, and (d) social dominance orientation. Results of a two‐phase study (N = 354) suggested that perceiving immigrants as a security concern was predictive of increased support for and greater odds of voting for Donald Trump three weeks later. Perceiving immigrants as an economic threat predicted odds of voting for Donald Trump, but only among liberals and there was no evidence of cultural concern or social dominance orientation (SDO) predicting support for Donald Trump or odds of voting for Trump. A follow‐up analysis of the cross‐sectional ANES survey corroborated that security concerns were an important correlate of voting for Trump, but also that SDO was correlated with having previously voted for Donald Trump. While our two‐phase study has the benefit of prediction, the cross‐sectional ANES data does not—“predictors” in these data were collected up to two months post‐election.