bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prior blood donations do not affect efficacy of G‐CSF mobilization nor outcomes of haematopoietic stem cell collection in healthy donors
Authors: Pruszczyk Katarzyna , Bartnik Krzysztof , Bogusz Krzysztof , Farhan Roiya , Cwil Dominika , Jastrzębska Aleksandra , Moskowicz Albert , Płachta Milena , Chmiel Adam , Skwierawska Kamila , Urbanowska Elżbieta , Jędrzejczak Wiesław Wiktor , Snarski Emilian 
Published: June 2019

Background and ObjectivesMany consider volunteer blood donors as ideal candidates for unrelated haematopoietic progenitor cell (HPC) donation. However, frequent blood donations could influence the results of HPC mobilization. To our best knowledge, there are no data on the possible impact of repeated blood donation on efficiency of subsequent HPC mobilization by granulocyte colony‐stimulating factor (G‐CSF).Materials and MethodsWe compared outcomes of HPC mobilization in unrelated donors with and without a history of blood donation. We conducted a prospective study on 287 consecutive donors admitted to the Department of Hematology since January 2016. The final analysis included 153 donors who agreed to take part in the study and had undergone stem cell mobilization with G‐CSF.ResultsHistory of blood donations prior to haematopoietic stem cell mobilization with G‐CSF does not have a significant impact on the number of collected CD34+ cells in the first leucocytapheresis (516.2 x 106 (170–1148) in blood donors vs 490.5 x 106 (101–1154) in non‐donors) (P = 0.32). In all donors, in this study mobilization of HPC was successful: 87.5% of blood donors and 85.6% of non‐donors collected the required cell number in a single apheresis. In blood donors, a higher number of blood donations within 2 and 5 years prior to HPC mobilization correlated significantly with successful donation within one leucocytapheresis (P = 0.014 and P = 0.024, respectively).ConclusionMultiple blood donations do not significantly influence the outcome of HPC collection in unrelated donors. Blood donors and non‐donors have similar results of HPC collection, so there is no reason to favour either group.
Body mass index and outcomes of patients with laparoscopic adrenalectomy: a systematic review and meta-analysis protocol
Authors: Danwang Celestin , Agbor Valirie Ndip , Bigna Jean Joel 
Published: June 2019

IntroductionRecent advances in the field of medical imaging and minimal invasive surgery have improved the diagnosis and treatment of adrenal incidentalomas. Recent studies suggest increased morbidity and mortality among patients with obesity following laparoscopic adrenalectomy compared with patients without obesity. However, this claim remains to be ascertained. This review seeks to assess the outcome of patients with and without obesity after adrenalectomy.Methods and designWe will include cohort studies, case-control studies, cross-sectional studies and case series with more than 30 participants. EMBASE, Medline and Web of Science (Web of Science Core Collection, Current Contents Connect, KCI-Korean Journal Database, SciELO Citation Index, Russian Science Citation Index) will be searched for relevant abstracts of studies published between 1 January 2000 and 31 May 2019, without language restriction. The review will be reported according to the Preferred Reporting Items for Systematic Review and Meta-Analysis guidelines. After screening of abstracts, study selection, data extraction and methodological quality assessment, we shall assess the studies individually for clinical and statistical heterogeneity. Random-effect meta-analysis will be used to pool studies judged to be clinically homogenous. The Harbord’s test and visual inspection of funnel plots will be used to assess publication bias. Results will be presented by country and region.Ethics and disseminationSince primary data are not collected in this study, ethical approval is not required. This review is expected to provide relevant data on the impact of body mass index on the outcome of laparoscopic adrenalectomy. The final report will be published in a peer-reviewed journal.PROSPERO registration numberCRD42018117070.Review statusPreliminary searches.
Exercise-based cardiac rehabilitation for stable angina: systematic review and meta-analysis
Authors: Long Linda , Anderson Lindsey , He jingzhou , Gandhi Manish , Dewhirst Alice , Bridges Charlene , Taylor Rod 
Published: June 2019

ObjectiveA systematic review was undertaken to assess the effects of exercise-based cardiac rehabilitation (CR) for patients with stable angina.MethodsDatabases (Cochrane Central Register of Controlled Trials, MEDLINE, Embase and CINAHL) were searched up to October 2017, without language restriction. Randomised trials comparing CR programmes with no exercise control in adults with stable angina were included. Where possible, study outcomes were pooled using meta-analysis. Grading of Recommendations Assessment, Development and Evaluation was used to assess the quality of evidence. The protocol was published on the Cochrane Database of Systematic Reviews.ResultsSeven studies (581 patients), with a median of 12-month follow-up, were included. The effect of exercise-based CR on all-cause mortality (risk ratio (RR) 1.01, 95 % CI: 0.18 to 5.67), acute myocardial infarction (RR 0.33, 95% CI: 0.07 to 1.63) and cardiovascular-related hospital admissions (RR 0.14, 95% CI: 0.02 to 1.1) relative to control were uncertain. We found low-quality evidence that exercise-based CR results in a moderate improvement in exercise capacity (standard mean difference 0.45, 95% CI: 0.20 to 0.70). There was limited and very low-quality evidence for the effect of exercise-based CR on health-related quality of life (HRQoL), adverse events and costs. No data were identified on cost-effectiveness or return to work.ConclusionsExercise-based CR may improve the short-term exercise capacity of patients with stable angina pectoris. Well-designed randomised controlled trials are needed to definitely determine the impact of CR on outcomes including mortality, morbidity, HRQoL, and costs in the population of patients with stable angina receiving contemporary medical therapy.
Multilevel approximation of parametric and stochastic PDES
Authors: Zech Jakob , Dũng Dinh , Schwab Christoph 
Published: June 2019

We analyze the complexity of the sparse-grid interpolation and sparse-grid quadrature of countably-parametric functions which take values in separable Banach spaces with unconditional bases. Assuming a suitably quantified holomorphic dependence on the parameters, we establish dimension-independent convergence rate bounds for sparse-grid approximation schemes. Analogous results are shown in the case that the parametric families are obtained as approximate solutions of corresponding parametric-holomorphic, nonlinear operator equations as considered in [A. Cohen and A. Chkifa and Ch. Schwab: Breaking the curse of dimensionality in sparse polynomial approximation of parametric PDEs, J. Math. Pures Appl. 103 (2015) 400–428], for example by means of stable, finite-dimensional approximations. We discuss in detail nonlinear Petrov–Galerkin projections. Error and convergence rate bounds for constructive and explicit multilevel, sparse tensor approximation schemes combining sparse-grid interpolation in the parameter space and general, multilevel discretization schemes in the physical domain are proved. The present results unify and generalize earlier works in terms of the admissible multilevel approximations in the physical domain (comprising general stable Petrov–Galerkin and discrete Petrov–Galerkin schemes, collocation and stable domain approximations) and in terms of the admissible operator equations (comprising smooth, nonlinear locally well-posed operator equations). Additionally, a novel computational strategy to localize sequences of nested index sets for the anisotropic Smolyak interpolation in parameter space is developed which realizes best [Formula: see text]-term benchmark convergence rates. We also consider Smolyak-type quadratures in this general setting, for which we establish improved convergence rates based on cancellations in the integrands’ gpc expansions by symmetries of quadratures and the probability measure [J.Z̃ech and Ch.S̃chwab: Convergence rates of high dimensional Smolyak quadrature, Report 2017-27, SAM ETH Zürich (2017)]. Several examples illustrating the abstract theory include domain uncertainty quantification (UQ) for general, linear, second-order, elliptic advection–reaction–diffusion equations on polygonal domains, where optimal convergence rates of FEM are known to require local mesh refinement near corners. Further applications of the presently developed theory comprise evaluations of posterior expectations in Bayesian inverse problems.
Efficiency of immunomodulatory therapy in the complex treatment of patients with combined craniofacial injuries
Authors: Ibragimov D. D. , Boymuradov Shuhrat A. 
Published: June 2019

Background: Our aim is to study the effectiveness of immunomodulatory therapy with Polyoxidonium in the complex treatment of patients with combined craniofacial injuries. Methods: In accordance with the intended purpose of this study, we conducted a comprehensive immunological examination of patients with combined craniofacial injuries in the dynamics of treatment with the drug authorized for use in healthcare practice: Polyoxidonium. In total 22 patients with combined craniofacial injuries in the complex therapy received Polyoxidonium at a dosage level of 6[Formula: see text]mg/m once for 5 days. Results: We conducted a comprehensive immunological study of the clinical course of the post-traumatic period in patients with combined craniofacial injuries which showed that the immunomodulatory therapy with Polyoxidonium during the complex treatment has a high clinical and immunological efficacy. Conclusions: Thus, in patients with combined craniofacial injuries, there is an immunodeficiency state involving both cellular immunity, manifested by a decrease in the level of T-lymphocytes, T-helpers, NK-cells and B-lymphocytes, and decrease of immunoglobulin production. The use of Polyoxidonium immunomodulator in complex therapy in patients with combined craniofacial injuries helped in improving the condition of patients in a shorter period of time and in preventing the development of purulent-inflammatory complications due to the positive dynamics of cellular and humoral immunity.
Rich Visual and Language Representation with Complementary Semantics for Video Captioning
Authors: Tang Pengjie , Wang Hanli , Li Qinyu 
Published: June 2019

It is interesting and challenging to translate a video to natural description sentences based on the video content. In this work, an advanced framework is built to generate sentences with coherence and rich semantic expressions for video captioning. A long short term memory (LSTM) network with an improved factored way is first developed, which takes the inspiration of LSTM with a conventional factored way and a common practice to feed multi-modal features into LSTM at the first time step for visual description. Then, the incorporation of the LSTM network with the proposed improved factored way and un-factored way is exploited, and a voting strategy is utilized to predict candidate words. In addition, for robust and abstract visual and language representation, residuals are employed to enhance the gradient signals that are learned from the residual network (ResNet), and a deeper LSTM network is constructed. Furthermore, three convolutional neural network based features extracted from GoogLeNet, ResNet101, and ResNet152, are fused to catch more comprehensive and complementary visual information. Experiments are conducted on two benchmark datasets, including MSVD and MSR-VTT2016, and competitive performances are obtained by the proposed techniques as compared to other state-of-the-art methods.
Paracellular transport of phosphate along the intestine
Authors: Knöpfel Thomas , Himmerkus Nina , Günzel Dorothee , Bleich Markus , Hernando Nati , Wagner Carsten A. 
Published: June 2019

Inorganic phosphate (Pi) is crucial for many biological functions, such as energy metabolism, signal transduction, and pH buffering. Efficient systems must exist to ensure sufficient supply for the body of Pifrom diet. Previous experiments in humans and rodents suggest that two pathways for the absorption of Piexist, an active transcellular Pitransport and a second paracellular pathway. Whereas the identity, role, and regulation of active Pitransport have been extensively studied, much less is known about the properties of the paracellular pathway. In Ussing chamber experiments, we characterized paracellular intestinal Pipermeabilities and fluxes. Dilution potential measurements in intestinal cell culture models demonstrated that the tight junction is permeable to Pi, with monovalent Pihaving a higher permeability than divalent Pi. These findings were confirmed in rat and mouse intestinal segments by use of Ussing chambers and a combination of dilution potential measurements and fluxes of radiolabeled32Pi. Both techniques yielded very similar results, showing that paracellular Pifluxes were bidirectional and that Pipermeability was ~50% of the permeability for Na+or Cl−. Pifluxes were a function of the concentration gradient and Pispecies (mono- vs. divalent Pi). In mice lacking the active transcellular Pitransport component sodium-dependent Pitransporter NaPi-IIb, the paracellular pathway was not upregulated. In summary, the small and large intestines have a very high paracellular Pipermeability, which may favor monovalent Pifluxes and allow efficient uptake of Pieven in the absence of active transcellular Piuptake.NEW & NOTEWORTHY The paracellular permeability for phosphate is high along the entire axis of the small and large intestine. There is a slight preference for monovalent phosphate. Paracellular phosphate fluxes do not increase when transcellular phosphate transport is genetically abolished. Paracellular phosphate transport may be an important target for therapies aiming to reduce intestinal phosphate absorption.
Loss of acid-sensing ion channel 2 enhances pulmonary vascular resistance and hypoxic pulmonary hypertension
Authors: Detweiler Neil D. , Herbert Lindsay M. , Garcia Selina M. , Yan Simin , Vigil Kenneth G. , Sheak Joshua R. , Resta Thomas C. , Walker Benjimen R. , Jernigan Nikki L. 
Published: June 2019

Acid-sensing ion channels (ASICs) are voltage-insensitive cation channels that contribute to cellular excitability. We previously reported that ASIC1 in pulmonary artery smooth muscle cells (PASMC) contribute to pulmonary vasoreactivity and vascular remodeling during the development of chronic hypoxia (CH)-induced pulmonary hypertension. However, the roles of ASIC2 and ASIC3 in regulation of pulmonary vasoreactivity and the development of CH-induced pulmonary hypertension are unknown. We tested the hypothesis that ASIC2 and ASIC3 contribute to increased pulmonary vasoreactivity and development of CH-induced pulmonary hypertension using ASIC2- and ASIC3-knockout (−/−) mice. In contrast to this hypothesis, we found that ASIC2−/−mice exhibit enhanced CH-induced pulmonary hypertension compared with WT and ASIC3−/−mice. This response was not associated with a change in ventilatory sensitivity or systemic cardiovascular function but was instead associated with direct changes in pulmonary vascular reactivity and pulmonary arterial morphology in ASIC2−/−mice. This increase in reactivity correlated with enhanced pulmonary arterial basal tone, elevated basal PASMC [Ca2+] and store-operated calcium entry (SOCE) in PASMC from ASIC2−/−mice. This increase in PASMC [Ca2+] and vasoreactivity was dependent on ASIC1-mediated Ca2+influx but was not contingent upon an increase in ASIC1 mRNA or protein expression in PASMC from ASIC2−/−mice. Together, the results from this study demonstrate an important role for ASIC2 to regulate pulmonary vascular reactivity and for ASIC2 to modulate the development of CH-induced pulmonary hypertension. These data further suggest that loss of ASIC2 enhances the contribution of ASIC1 to overall pulmonary vascular reactivity.NEW & NOTEWORTHY This study demonstrates that loss of ASIC2 leads to increased baseline pulmonary vascular resistance, enhanced responses to a variety of vasoconstrictor stimuli, and greater development of hypoxic pulmonary hypertension. Furthermore, these results suggest that loss of ASIC2 enhances the contribution of ASIC1 to pulmonary vascular reactivity.
Prognostic Impact of Atrial Fibrillation in Acute Myocardial Infarction and Cardiogenic Shock
Authors: Feistritzer Hans-Josef , Desch Steffen , Zeymer Uwe , Fuernau Georg , de Waha-Thiele Suzanne , Dudek Dariusz , Huber Kurt , Stepinska Janina , Schneider Steffen , Ouarrak Taoufik , Thiele Holger 
Published: June 2019

Background:
It is unclear whether atrial fibrillation (AF) influences prognosis in patients with cardiogenic shock and multivessel disease. We aimed to investigate the prognostic impact of AF in patients with cardiogenic shock complicating acute myocardial infarction.

Methods and Results:

In a subanalysis of the CULPRIT-SHOCK trial (Culprit Lesion Only PCI versus Multivessel PCI in Cardiogenic Shock), patients were grouped according to the presence of AF during index hospital stay. The primary end point was all-cause death at 30 days, and the key secondary end point was all-cause death at 1 year. AF was documented in 142 (21%) of 686 patients. AF was not a significant predictor of 30-day (adjusted odds ratio, 1.01; 95% CI 0.67–1.54;
P
=0.95) and 1-year (adjusted odds ratio, 0.80; 95% CI, 0.52–1.22;
P
=0.30) all-cause mortality. Patients with AF already on admission showed higher all-cause mortality at 30 days (52 of 90, 58% versus 19 of 52, 37%;
P
=0.02) and 1 year (57 of 90, 63% versus 20 of 52, 39%;
P
=0.004) compared with patients with newly detected AF during hospital stay. AF was associated with a longer time to hemodynamic stabilization (4, interquartile range, 1–8 days versus 3, interquartile range, 1–6 days;
P
=0.04) at 30 days.

Conclusions:
In cardiogenic shock complicating acute myocardial infarction, all-cause mortality is similar in patients with and without AF. Adverse outcome was detected in the subgroup of patients showing AF already on hospital admission.

Clinical Trial Registration:

URL:
https://www.clinicaltrials.gov
. Unique identifier: NCT01927549.
Farmalarm
Authors: Requena Manuel , Montiel Estefanía , Baladas María , Muchada Marian , Boned Sandra , López Rosa , Rodríguez-Villatoro Noelia , Juega Jesús , García-Tornel Álvaro , Rodríguez-Luna David , Pagola Jorge , Rubiera Marta , Molina Carlos A. , Ribo Marc 
Published: June 2019

Background and Purpose—
Risk factor control and treatment compliance in the following months after stroke are poor. We aim to validate a digital platform for smartphones to raise awareness among patients about the need to adopt healthy lifestyle, improve communication with medical staff, and treatment compliance.

Methods—
Farmalarm is an application (app) for smartphones designed to increase stroke awareness by medication alerts and compliance control, chat communication with medical staff, didactic video files, exercise monitoring. Patients with stroke discharged home were screened for participation and divided into groups: to follow the FARMALARM program for 3 to 4 weeks or standard of care follow-up. We determined achievement of risk factor control goals at 90 days.

Results—

From August 2015 to December 2016, from the 457 patients discharged home, 159 (34.8%) were included: Farmalarm (n=107); age 57±12, Control (n=52), age 59±10; without significant differences in baseline characteristics between groups. At 90 days, knowledge of vascular risk factors was higher in FARMALARM group (86.0% versus 69.2%,
P
<0.01). The rate of patients with diabetes mellitus (83.2% versus 63.5%,
P
<0.01) and hypercholesterolemia (80.3% versus 63.5%,
P
=0.03) under control and the rate of patients with 4 out of 4 risk factors under control was higher in FARMALARM group (50.4% versus 30.7%,
P
=0.02). A regression model showed that the use of Farmalarm was independently associated with all risk factors under control at 90 days (odds ratio, 2.3; 95% CI, 1.14–4.6;
P
=0.02).

Conclusions—
In patients with stroke discharged home, the use of mobile apps to monitor medication compliance and increase stroke awareness is feasible and seems to improve the control of vascular risk factors.
Sex Differences in Management and Outcomes of Acute Ischemic Stroke With Large Vessel Occlusion
Authors: Uchida Kazutaka , Yoshimura Shinichi , Sakai Nobuyuki , Yamagami Hiroshi , Morimoto Takeshi ,   RESCUE-Japan Registry 2 Investigators
Published: June 2019

Background and Purpose—
Sex differences in the management and outcomes of acute ischemic stroke with large vessel occlusion are unknown in the era of endovascular therapy (EVT). This study investigated these differences in the RESCUE (Recovery by Endovascular Salvage for Cerebral Ultra-Acute Embolism)-Japan Registry 2 patient database.

Methods—
RESCUE-Japan Registry 2 registered patients with large vessel occlusion who were admitted within 24 hours of onset were enrolled in this study. We estimated the likelihood to receive EVT according to sex. The primary outcome was good outcome defined as a modified Rankin Scale score of 0 to 2 at 90 days after onset. Secondary outcomes were mortality within 90 days, any or symptomatic intracranial hemorrhage within 72 hours, and recurrence of stroke or transient ischemic attack within 90 days.

Results—

Among 2399 patients, 1087 patients were female and 1312 were male; 47.9% of females and 57.7% of males received EVT (adjusted odds ratio, 0.71; 95% CI, 0.59–0.86). Good outcome was observed in 27.3% and 44.2% of the females and males, respectively (
P<
0.0001). The adjusted odds ratio of a good outcome in females was 0.80 (95% CI, 0.65–0.99). Mortality was 12.3% and 9.9% in females and males, respectively (
P
=0.06); the adjusted odds ratio was 0.78 (95% CI, 0.58–1.05).

Conclusions—
Females with acute ischemic stroke with large vessel occlusion showed poor functional outcome compared to males. Females were less likely to receive EVT; lower utilization of EVT accounted for a portion of the poor outcome.
Development of Near-Cloud Turbulence Diagnostics Based on a Convective Gravity Wave Drag Parameterization
Authors: Kim Soo-Hyun , Chun Hye-Yeong , Sharman Robert D. , Trier Stanley B. 
Published: June 2019

AbstractWe propose near-cloud turbulence (NCT) diagnostics for use in aviation turbulence forecasting, using a convective gravity wave drag (CGWD) parameterization scheme. The NCT diagnostics are obtained based on (i) CGWD and (ii) minimum Richardson number including the effects of convective gravity waves (CGWs). The feasibility of the NCT diagnostics is examined using numerical simulation results of real turbulence cases related to the breaking of CGWs, which occurred over eastern Missouri and southwestern Illinois in the United States on 9–10 March 2006, and near Fukuoka, Japan, on 2 September 2007. On 9–10 March 2006, several instances of moderate-or-greater (MOG)-intensity turbulence were reported above shallow but active convection over the central United States, while on 2 September 2007, severe turbulence was encountered above dissipating convection near Fukuoka, Japan. The high-resolution simulation results for both turbulence events show that CGWs and their breaking provide favorable environments for turbulence generation. For two simulated real cases, nonzero NCT diagnostics are reasonably well matched with observed turbulence encounters. The global distribution of CGWD calculated using global reanalysis data revealed a high potential of MOG turbulence in the tropics and the midlatitudes, which can be clearly distinguished from the traditional clear-air turbulence index where high potentials of MOG turbulence are diagnosed in the midlatitudes associated with the strong vertical wind shears near jet streams. These results imply that the proposed NCT diagnostics are useful for forecasting turbulence related to the breaking of CGWs, especially, in tropical regions.