bluuebunny/crossref_metadata_2025_split huggingface dataset:
Active coping moderates associations among race-related stress, rumination, and depressive symptoms in emerging adult African American women
Authors: Hill Labarron K. , Hoggard Lori S. 
Published: November 2018

AbstractCross-sectional and longitudinal research has shown that race-related stress is associated with increased depressive symptoms among racial/ethnic minorities. Rumination has long been considered a maladaptive self-regulatory response to race-related stress, and growing evidence suggests that it may be an important link in the relation between race-related stress and depression. More adaptive forms of self-regulation, such as active coping, may counteract the negative impact of rumination. We examined the influence of rumination on the relation between race-related stress and depressive symptoms in a sample (N = 69) of young adult (mean age = 20 ± 1.5 years) African American women. We also considered the possible moderating effects of John Henryism, a form of persistent and determined goal striving, and vagally mediated heart rate variability, a purported biomarker of coping. Anticipatory race-related stress was indirectly associated with depressive symptoms through rumination: estimate = 0.07, 95% confidence interval [0.01, 0.16]. Both John Henryism and vagally mediated heart rate variability moderated the relationship between race-related stress and rumination; however, only John Henryism reliably influenced the indirect association between race-related stress and depression through rumination. We discuss these findings in the context of growing research examining the interplay between cultural and biological factors in the risk for poorer mental health.
Genetic moderation of the effects of the Family Check-Up intervention on children's internalizing symptoms: A longitudinal study with a racially/ethnically diverse sample
Authors: Lemery-Chalfant Kathryn , Clifford Sierra , Dishion Thomas J. , Shaw Daniel S. , Wilson Melvin N. 
Published: November 2018

AbstractDevelopment involves synergistic interplay among genotypes and the physical and cultural environments, and integrating genetics into experimental designs that manipulate the environment can improve understanding of developmental psychopathology and intervention efficacy. Consistent with differential susceptibility theory, individuals can vary in their sensitivity to environmental conditions including intervention for reasons including their genotype. As a consequence, understanding genetic influences on intervention response is critical. Empirically, we tested an interaction between a genetic index representing sensitivity to the environment and the Family Check-Up intervention. Participants were drawn from the Early Steps Multisite randomized prevention trial that included a low-income and racially/ethnically diverse sample of children and their families followed longitudinally (n = 515). As hypothesized, polygenic sensitivity to the environment moderated the effects of the intervention on 10-year-old children's symptoms of internalizing psychopathology, such that children who were genetically sensitive and were randomly assigned to the intervention had fewer symptoms of child psychopathology than genetically sensitive children assigned to the control condition. A significant difference in internalizing symptoms assessed with a clinical interview emerged between the intervention and control groups for those 0.493 SD above the mean on polygenic sensitivity, or 25% of the sample. Similar to personalized medicine, it is time to understand individual and sociocultural differences in treatment response and individualize psychosocial interventions to reduce the burden of child psychopathology and maximize well-being for children growing up in a wide range of physical environments and cultures.
Physical and psychosocial development of Mapuche and nonindigenous Chilean toddlers: A modest role of ethnicity
Authors: Navarrete Marcelo A. , Silva Jaime R. , Van Ijzendoorn Marinus H. , Cárcamo Rodrigo A. 
Published: November 2018

AbstractMapuche represents the largest indigenous group in Chile amounting to nearly 10% of the total population. In a longitudinal cohort of 12,398 children, we analyzed the role of ethnicity in physical and psychosocial development of Mapuche and nonindigenous Chilean toddlers (age 2.5 years), taking into account sociodemographic and caregiver characteristics. As indicated by our univariate analysis, the Mapuche developmental niche was characterized by lower income, lower maternal education, poorer quality of the home environment, longer breastfeeding, and higher parental stress. Physical development showed higher body mass index. Mapuche children showed less externalizing problems. We then analyzed the incremental contribution of ethnicity in a series of hierarchical regressions with the second wave of developmental measurements (age 4.5 years) as outcome variables, showing a significant but modest incremental contribution of ethnicity to the prediction of children's development between 2.5 and 4.5 years of age. Controlling for environmental variables, Mapuche showed less externalizing and internalizing, behavior problems. Socioeconomic status, quality of the home environment, and parenting stress were stronger predictors of socioemotional development than ethnicity per se.
Dose verification of volumetric-modulated arc therapy using one-dimensional and two-dimensional dosimeters
Authors: Rehman Jalil ur , Syed Zahra , Hussain Ghulam , Ahmad Nisar , Asghar H M Noor ul Huda Khan , Gilani Zaheer Abbas , Nasar Gulfam , Akhter Malik M , Isa Muhammad , Iqbal Tahir 
Published: November 2018

AbstractPurposeTo verify dose delivery and quality assurance of volumetric-modulated arc therapy (VMAT) for head and neck (H&amp;N) cancer.MethodThe Imaging and Radiation Oncology Core Houston (IROC-H) H&amp;N phantom with thermoluminescent dosimeters (TLDs) and films, were imaged with computed tomography scan and the reconstructed image was transferred to pinnacle treatment planning system (TPS). On TPS, the planning target volume (PTV), secondary target volume (STV) and organ at risk (OAR) were delineated manually and a treatment plan was made. The dose constraints were determined for the concerned organs according to IROC-H prescription. The treatment plan was optimised using adoptive convolution algorithm to improve dose homogeneity and conformity. The dose calculation was performed using C.C Convolution algorithm and a Varian True Beam linear accelerator was used to deliver the treatment plan to the H&amp;N phantom. The delivered radiation dose to the phantom was measured through TLDs and GafChromic external beam radiotherapy 2 (EBT2) films. The dosimetric performance of the VMAT delivery was studied by analysing percent dose difference, isodose line profile and gamma analysis of the TPS-computed dose and linac-delivered doses.ResultThe percent dose difference of 3.8% was observed between the planned and measured doses of TLDs and a 1.5-mm distance to agreement (DTA) was observed by comparing isodose line profiles. Passed the gamma criteria of 3%/3 mm was with good percentages.ConclusionThe dosimetric performance of VMAT delivery for a challenging H&amp;N radiotherapy can be verified using TLDs and films embedded in an anthropomorphic H&amp;N phantom.
Assessing threats to shallow groundwater quality from soil pollutants in Glasgow, UK: development of a new screening tool
Authors: Fordyce F. M. , Ó Dochartaigh B. É. , Bonsor H. C. , Ander E. L. , Graham M. T. , McCuaig R. , Lovatt M. 
Published: November 2018

ABSTRACTA new GIS-based screening tool to assess threats to shallow groundwater quality has been trialled in Glasgow, UK. The GRoundwater And Soil Pollutants (GRASP) tool is based on a British Standard method for assessing the threat from potential leaching of metal pollutants in unsaturated soil/superficial materials to shallow groundwater, using data on soil and Quaternary deposit properties, climate and depth to groundwater. GRASP breaks new ground by also incorporating a new Glasgow-wide soil chemistry dataset. GRASP considers eight metals, including chromium, lead and nickel at 1622 soil sample locations. The final output is a map to aid urban management, which highlights areas where shallow groundwater quality may be at risk from current and future surface pollutants. The tool indicated that 13% of soil sample sites in Glasgow present a very high potential threat to groundwater quality, due largely to shallow groundwater depths and high soil metal concentrations. Initial attempts to validate GRASP revealed partial spatial coincidence between the GRASP threat ranks (low, moderate, high and very high) and groundwater chemistry, with statistical correlation between areas of high soil and groundwater metal concentrations for both Cr and Cu (r2>0.152; P<0.05). Validation was hampered by a lack of, and inconsistency in, existing groundwater chemistry data. To address this, standardised subsurface data collection networks have been trialled recently in Glasgow. It is recommended that, once available, new groundwater depth and chemistry information from these networks is used to validate the GRASP model further.
Determining the fate of missing persons: The importance of archives for “dealing with the past” mechanisms
Authors: Baumgartner Elisabeth , Ott Lisa 
Published: November 2018

AbstractThis article discusses the role of archives of transitional justice and “dealing with the past” (DWP) mechanisms when determining the fate of missing persons. The concept of dealing with the past, the terms “enforced disappearance” and “missing person”, and the specific role of archives in periods of transition are examined. Subsequently, specific questions and challenges related to access and use of archives by DWP mechanisms, including those mechanisms with a mandate to determine the fate of missing persons, are described. Many questions related to access to archives, information management and preservation of records are similarly applicable to DWP mechanisms in general and to specific mechanisms mandated to search for missing persons. The article provides some examples of States’ obligations related to maintaining and providing access to archives that could assist in the search for missing persons under international law and policy. The article concludes by emphasizing the importance of the preservation and protection of archives relevant for dealing with the past. It further highlights the need to grant DWP mechanisms, especially those aimed at determining the fate of missing persons, access to those archives.
Think Ahead: Cost Discounting and External Validity in Foreign Policy Survey Experiments
Authors: Huddleston R. Joseph 
Published: November 2018

AbstractThis paper considers the implications of construal level theory in the context of survey experiments probing foreign policy opinion formation. Psychology research demonstrates that people discount the long-term consequences of decisions, thinking about distal or hypothetical events more abstractly than immediate scenarios. I argue that this tendency introduces a bias into survey experiments on foreign policy opinion. Respondents reasoning about an impending military engagement are likelier to consider its costs than are those reasoning in the abstract hypothetical environment. I provide evidence of this bias by replicating a common audience costs experimental design and introducing a prompt to consider casualties. I find that priming respondents to articulate their expectations about casualties in a foreign intervention reduces support and dampens the experimental effect, thereby cutting the estimated absolute audience cost substantially. This result suggests a gap between how survey respondents approach hypothetical and real situations of military intervention.
Revisiting Earthquakes in the Los Angeles, California, Basin During the Early Instrumental Period: Evidence for an Association With Oil Production
Authors: Hough Susan E. , Bilham Roger 
Published: November 2018

AbstractA total of seven independentML ≥ 4.0 earthquakes occurred in the Los Angeles, California, basin, during the early instrumental period between 1932 and 1952, the largest of which was the 1933 Long Beach earthquake. Revising available macroseismic and instrumental data for a total of 6 4.0 ≤ ML ≤ 5.1 events between 1938 and 1944, we conclude that early instrumental locations can be grossly inconsistent with detailed macroseismic data. We use available macroseismic data to revisit event locations. We further present evidence that most if not all of these moderate earthquakes may have been induced by oil production. We quantify the predicted stress change associated with production from eight oil fields in the southwestern Los Angeles basin and show that frictional failure would have been encouraged beneath and at the periphery of high‐volume fields, with stress changes upward of 0.1 MPa at 5‐km depth. The results suggest that if earthquakes are induced by stress changes associated with production, the magnitudes of events might tend to be limited by the limited spatial extent of lobes of increased Coulomb failure stress. It further appears that the advent of fluid injection recovery methods (water‐flooding) around 1960 mitigated induced earthquake risk considerably.
EPH receptor A2 governs a feedback loop that activates Wnt/β-catenin signaling in gastric cancer
Authors: Peng Qiu , Chen Ling , Wu Wei , Wang Jia , Zheng Xiang , Chen Zihua , Jiang Qin , Han Jiaqi , Wei Lingyu , Wang Lujuan , Huang Jin , Ma Jian 
Published: November 2018

AbstractThe erythropoietin-producing hepatoma (EPH) receptor A2 (EphA2) belongs to the Eph family of receptor tyrosine kinases. EphA2 is highly correlated with the formation of many solid tumors and has been linked to the dysregulation of signaling pathways that promote tumor cell proliferation, migration, and invasion as well as angiogenesis. Deregulation of Wnt signaling is implicated in many forms of human disease including gastric cancer. We previously reported that EphA2 promotes the epithelial–mesenchymal transition through Wnt/β-catenin signaling in gastric cancer. Herein, we present a novel mechanism by which EphA2 regulates Wnt/β-catenin signaling. EphA2 acts as a receptor for Wnt ligands and recruits Axin1 to the plasma membrane by directly binding Dvl2. The EphA2-Dvl2/Axin1 interaction was enhanced by Wnt3a treatment, suggesting that EphA2 acts as a functional receptor for the Wnt/β-catenin pathway and plays a vital role in downstream signaling. We showed that Dvl2 mediates the EphA2-Axin1 interaction by binding to the tyrosine kinase domain of EphA2. We propose that EphA2/Dvl2/Axin1 forms a complex that destabilizes the β-catenin destruction complex and allows β-catenin to translocate to the nucleus and initiate the transcription of c-MYC, the primary Wnt signaling target gene. Intriguingly, c-MYC could bind directly to the EphA2 and Wnt1 promoter to enhance their transcription. The entire process formed an EphA2-mediated feed-forward loop. A small molecular inhibitor of EphA2 potently inhibited the proliferation of gastric cancer in vitro and in vivo, including gastric cancer patient–derived xenografts. Thus, our data identify EphA2 as an excellent candidate for gastric cancer therapy.
Autophagy promotes angiogenesis via AMPK/Akt/mTOR signaling during the recovery of heat-denatured endothelial cells
Authors: Liang Pengfei , Jiang Bimei , Li Yuanbin , Liu Zhenguo , Zhang Pihong , Zhang Minghua , Huang Xiaoyuan , Xiao Xianzhong 
Published: November 2018

AbstractOur previous study demonstrated that angiogenesis increased during the recovery of heat-denatured endothelial cells. However, the mechanism is still unclear. This study aimed to investigate the relation of autophagy and angiogenesis during the recovery of heat-denatured endothelial cells. A rat deep partial-thickness burn model and heat-denatured human umbilical vein endothelial cells (HUVECs) model (52 °C for 35 s) were used. Autophagy increased significantly in the dermis and HUVECs in a time-dependent manner after heat denaturation and recovery for 2–5 days. Rapamycin-mediated autophagy enhanced the pro-angiogenic effect, evidenced by increased proliferation and migration of HUVECs, and formation of tube-like structures. Autophagy inhibition by 3-Methyladenine (3-MA) abolished the angiogenesis in heat-denatured HUVECs after recovery for 3–5 days. Moreover, heat denaturation augmented the phosphorylation of AMP-activated protein kinase (AMPK) but reduced the phosphorylation of Akt and mTOR in HUVECs. Furthermore, autophagy inhibition by antioxidant NAC, compound C or AMPK siRNA impaired cell proliferation, migration and tube formation heat-denatured HUVECs. At last, the in vivo experiments also showed that inhibition of autophagy by bafilomycin A1 could suppress angiogenesis and recovery of heat-denatured dermis.Taken together, we firstly revealed that autophagy promotes angiogenesis via AMPK/Akt/mTOR signaling during the recovery of heat-denatured endothelial cells and may provide a potential therapeutic target for the recovery of heat-denatured dermis.
Whole-genome sequences of Malawi cichlids reveal multiple radiations interconnected by gene flow
Authors: Malinsky Milan , Svardal Hannes , Tyers Alexandra M. , Miska Eric A. , Genner Martin J. , Turner George F. , Durbin Richard 
Published: November 2018

AbstractThe hundreds of cichlid fish species in Lake Malawi constitute the most extensive recent vertebrate adaptive radiation. Here we characterize its genomic diversity by sequencing 134 individuals covering 73 species across all major lineages. The average sequence divergence between species pairs is only 0.1–0.25%. These divergence values overlap diversity within species, with 82% of heterozygosity shared between species. Phylogenetic analyses suggest that diversification initially proceeded by serial branching from a generalistAstatotilapia-like ancestor. However, no single species tree adequately represents all species relationships, with evidence for substantial gene flow at multiple times. Common signatures of selection on visual and oxygen transport genes shared by distantly related deep-water species point to both adaptive introgression and independent selection. These findings enhance our understanding of genomic processes underlying rapid species diversification, and provide a platform for future genetic analysis of the Malawi radiation.
Cobalt doping of tin disulfide/reduced graphene oxide nanocomposites for enhanced pseudocapacitive sodium-ion storage
Authors: Jia Hao , Chen Chen , Oladele Olabode , Tang Yongan , Li Guoqing , Zhang Xiangwu , Yan Fei 
Published: November 2018

AbstractRechargeable sodium-ion batteries are receiving intense interest as a promising alternative to lithium-ion batteries, however, the absence of high-performance anode materials limits their further commercialization. Here we prepare cobalt-doped tin disulfide/reduced graphene oxide nanocomposites via a microwave-assisted hydrothermal approach. These nanocomposites maintain a capacity of 636.2 mAh g−1 after 120 cycles under a current density of 50 mA g−1, and display a capacity of 328.3 mA h g−1 after 1500 cycles under a current density of 2 A g−1. The quantitative capacitive analysis demonstrates that the electrochemical performance of the nanocomposite originates from the combined effects of cobalt and sulfur doping, resulting in the enhanced pseudocapacitive contribution (52.8 to 89.8% at 1 mV s−1) of tin disulfide. This work provides insight into tuning the structure of layered transition metal dichalcogenides via heteroatom doping to develop high-performance anode materials for sodium-ion batteries.
Lumbar Spine Injuries: Primary Prevention in Amateur and Professional Golf Players
Authors: Goebel Dietmar , Drollinger Frank , Drollinger Andrea 
Published: November 2018

AbstractIn the sport of golf, there is no standard teaching method or swing technique even though golf is known for overuse injuries. This prospective study was to analyze classic swing kinematics in comparison with the Free-Release® method and to define a physiological golf swing. Two hundred eighty-three players, age 50–59 years, were included in the study. For both swing techniques, examination addressed swing visualization, center of pressure (COP), center of mass (COM), as well as pelvic movement in relationship to different standing widths. The position of the spine was evaluated in the frontal and lateral planes. Using the classic technique, no golfer was able to describe his swing parameters, which would be necessary for visualization and to tolerate physiological range of movement, whereas players using the Free-Release method® were able to provide such a description. COP and COM showed pathological swing mechanics for the classic technique, whereas for the Free-Release method mechanics were physiological. We conclude that to prevent lumbar spine injury, the classic swinging technique, which is characterized by lateral shear forces, static and dynamic pelvic side bending while rotating with high force against the spine, and an unbalanced COM and COP, should be substituted by the Free-Release technique as a new physiological guideline.
Influence of Medication-Induced Preconditioning or Remote Ischemic Preconditioning on the Intrinsic Vascular Extracellular RNA/Ribonuclease System in Cardioprotection
Authors: Tolkmitt Konstantin J. , Simsekyilmaz Sakine , Schipke Julia , Mühlfeld Christian , Preissner Klaus T. , Böning Andreas 
Published: November 2018

Abstract
Background It has been demonstrated that remote ischemic preconditioning (RIPC) increases ribonuclease (RNase) levels and protects the heart by reducing extracellular ribonucleic acid (eRNA). As medication-induced preconditioning (MIPC) is also a powerful tool for cardioprotection, we examined the influence of both types of preconditioning on the eRNA/RNase system.
Methods In 17 male rats, RIPC (3 × 5 minute hind-leg ischemia) or MIPC (isoflurane and buprenorphine anesthesia) was performed. Five rats served as control and did not undergo preconditioning (non-MIPC). After preconditioning, eRNA levels and RNase activity were determined in plasma, and the hearts were mounted on a blood-perfused Langendorff ischemia/reperfusion apparatus. Hemodynamic, metabolic, and electron microscopic parameters were determined. Furthermore, MIPC with one anesthetic drug only (isoflurane, buprenorphine, or etomidate) was induced in another five rats. After 30 minutes, eRNA levels and RNase activity were determined and compared with an RIPC group (n = 5).
Results The plasma of RIPC-treated rats had higher RNase activity and lower eRNA levels than that of MIPC-treated rats. In addition, RIPC increased RNase activity more than MIPC with one drug alone. The RNase activity and eRNA levels in these MIPC groups differed considerably. Hemodynamic parameters of RIPC- and MIPC-treated hearts were better preserved after 90-minute ischemia than those of non-MIPC hearts. No obvious differences were noted between MIPC and RIPC regarding hemodynamics, metabolism, or structural parameters.
Conclusions Our results suggest that RIPC does not have any additional cardioprotective benefit in this experimental system. However, the influence of RIPC on the eRNA/RNase system was greater than that of MIPC.