bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efek Pemberian Ekstrak Etanol Daun Dan Batang Ubi Jalar Ungu (Ipomoea batatas L.) Terhadap Penurunan Kadar Glukosa Darah Pada Tikus Jantan Galur Wistar Yang Diinduksi Aloksan
Authors: Haryoto Haryoto , Devi Ermia Septiana 
Published: January 2019

Tanaman ubi jalar ungu (Ipomoea batatas L.) mudah didapat dan banyak kegunaannya,terutama bagian umbi ubi jalar ungu yang banyak diolah masyarakat sedangkan bagian daun dan batang pemanfaatnya belum maksimal. Umbinya telah diketahui mempunyai aktivitas dapat menurunkan kadar gula darah. Penelitian ini bertujuan untuk mengetahui efek penurunan kadar glukosa darah dari ekstrak etanol daun dan batang ubi jalar ungu serta golongan senyawa yang terkandung dalam ekstrak. Desain penelitian menggunakan randomized pre-test post-test kontrol grup desain. Pada penelitian ini menggunakan 15 ekor tikus jantan galur wistar dan dibagi menjadi 5 kelompok yaitu kontrol negatif (akuades), kontrol positif (metformin 45 mg/kgBB), kelompok perlakuan ubi jalar ungu dosis 150; 300; 600 mg/kgBB, sebelumnya masing –masing tikus dinduksi dengan aloksan 150 mg/kgBB, dan dilakukan pemantauan selama 14 hari. Pemeriksaan kadar gula darah menggunakan spektrofotometer visibel dengan panjang gelombang 500 nm. Data dianalisis secara statistik untuk mengetahui perubahan kadar gula darah. Hasil yang didapat dengan pemberian ekstrak pada dosis 150, 300, dan 600 mg/kgBB selama pemantauan 14 hari dapat menurunkan kadar gula darah berturut – turut menjadi 96,33 ± 4,72 ; 66,67 ± 16,16 ; dan 142,67 ± 27,06 mg/dL. Ekstrak etanol daun dan batang ubi jalar ungu memiliki kandungan senyawa yaitu alkaloid, flavonoid, saponin, tanin dan senyawa fenolik.

The purple sweet potato plant (Ipomoea batatas L.) is easy to obtain and has many uses, especially the purple sweet potato tubers which are mostly utilized by the people, while the utilization of its leaves and stem are not maximized. Its tuber has been known to have activity in reducing blood sugar levels.This research aimed to evaluate the effect of ethanol extract of leaves and stems of purple sweet potatoes in reducing blood glucose level as well as to identify its chemical constituents. The study was design by a randomized pre-test post-test control group. The animal used were 15 wistar male rats which divided into 5 groups, these include negative control (distilled water), positive control (metformin 45 mg/kgBW), treatment group of purple sweet potatoes with the doses of 150; 300; 600 mg/kgBW, before the treatment all rats were induced by aloxan 150 mg/kgBW, and all groups were observed for 14 days.
Blood glucose level was determined using UV-Vis spectophotometer at wavelength of 500 nm. The data were analyzed statistically to evaluate blood glucose level alteration. The result showed that the extract at doses of 150, 300, dan 600 mg/kgBW decrease blood glucose level in 14 days observation, the blood glucose levels were 96.33 ± 4.72 ; 66.67 ± 16.16 ; and 142.67 ± 27.06 mg/dL, respectively. The ethanol extract of leaves and stem of purple sweet potatoescontained alkaloids, flavonoids, saponins, tannins and phenolic compounds
Gambaran Penyembuhan Luka Tikus Diabetes Dengan Fraksi Etil Asetat Daun Binahong (Anredera cordifolia (Tenore) Steenis)
Authors: Elfasyari Trie Yuni , Kintoko Kintoko , Nurkhasanah Nurkhasanah 
Published: January 2019

Proses penyembuhan luka kulit dipengaruhi oleh kondisi dibetes mellitus (DM). Ekstrak etanol daun binahong dilaporkan dapat mempercepat penyembuhan luka tikus diabetes melalui mekanisme reepitelisasi dan kolagenasi. Penelitian ini dilakukan untuk mengetahui gambaran penyembuhan luka diabetes fraksi etil asetat daun binahong (Anredera cordifolia (Ten.) Steenis) konsentrasi 10% dengan parameter jumlah sel fibroblast pada tikus yang diinduksi sterptozotocin. Metode fraksinasi yang digunakan fraksinasi bertingkat padat cair dengan pelarut etil asetat yang bersifat semipolar. Penelitian eksperimental menggunakan 20 ekor tikus Wistar jantan usia 2 bulan, berat badan antara 150-200 gram yang diinduksi streptozotocin (STZ) dosis tunggal 45 mg/kgBB i.p. Punch biopsy digunakan untuk membuat luka pada kulit tikus dengan diameter 5 mm setelah kadar glukosa darah (KGD) di atas 250 mg/dL. Hewan uji dibagi menjadi 4 kelompok, terdiri dari kontrol sehat (tanpa induksi STZ dan tanpa perlakuan), kontrol negatif (biocream), kontrol positif (madecassol), dan fraksi etil asetat daun binahong 10% (dalam biocream). Aplikasi topikal dilakukan 2 kali sehari sebanyak 25 mg selama 10 hari pada area luka dan sekitarnya. Pengamatan dilakukan secara makroskopis dan mikroskopis. Penelitian menunjukkan bahwa fraksi etil asetat daun binahong mengandung senyawa flavonoi dan tanin, serta berperan dalam meningkatkan jumlah sel fibroblast (P<0.05).

Wound healing process is affected by diabetes melitus condition. The ethanol extract of Binahong leaves has reported to have wound healing activity on diabetic rat through mechanism of re-epithelialization and collagenation. This study was conducted to evaluate the wound healing activity on diabetic rat of ethyl acetate fraction of Binahong (Anredera cordifolia (Tenore) Steenis) leaves at concentration of 10% with parameters of fibroblast numbers in streptozozin induced rat. The fractionation method used was solid-liquid graded fractination using ethyl acetate as semipolar solvent. This experimental research used 20 male wistar rats, aged 2 months, weight 150-200 g, induced by single dose streptozotocin (STZ)45 mg/kgBB i.p. Punch biopsy was used to injured the rat skin with diameter of 5 mm after blood glucose level was more than 250 mg/dL. Test animals were divided into 4 groups, these include healthy control (without induced by STZ and treatment), negative control (biocream), positive control (madecassol), ethyl acetate fraction of binahong leaves 10% (in biocream). The cream was applied topically 2 times a day with an amount of 25 mg for 10 days on wound area and surrounding. The macroscopic and microscopic observation was performed. The results showed that ethyl acetate fraction of binahong leaves contained flavonoids and tannin, besides it plays role to increase the fibroblast numbers (P<0.05).
Identifikasi Senyawa Kimia Aktif Antioksidan Dari Ekstrak Etil Asetat Buah Andaliman (Zanthoxylum acanthopodium DC)
Authors: Winarti Wiwi , Simanjuntak Partomuan , Syahidin Muhammad Fahmi 
Published: January 2019

Buah andaliman, (Zanthoxylum acanthopodium DC),banyak dikonsumsi oleh masyarakat sebagai bumbu makanan dan obat tradisional seperti obat sakit perut, tonikum, dan anti mikroba. Penelitian ini bertujuan untuk mengidentifikasi senyawa yang berkhasiat sebagai antioksidan dari ekstrak buah andaliman. Ekstraksi dilakukan secara maserasi kinetik menggunakan pelarut n-heksan, dan etil asetat. Ekstrak kental yang diperoleh kemudian diuji aktivitas antioksidan dengan metode peredaman radikal bebas menggunakan DPPH. Sebagai kontrol positif digunakan vitamin C. Selanjutnya dilakukan pemurnian dengan kromatografi kolom sampai diperoleh isolat EA.X.6.1 yang mempunyai aktivitas antioksidan tertinggi. Hasil uji aktivitas antioksidan dengan metode peredaman radikal bebas DPPH (1,1-difenil-2-pikrilhidrazil) menunjukkan bahwa ekstrak etil asetat buah andaliman mempunyai aktivitas antioksidan dengan nilai IC50 sebesar 66,91 bpj, dan isolat EA.X.6.1 yang memiliki aktivitas antioksidan tertinggi dengan nilai IC50 sebesar 135,58 bpj. Berdasarkan hasil analisis dengan spektrofotometri UV-Vis, spektrofotometri Fourier Transform Infra Red (FT- IR) dan Kromatografi Gas-Spektrometri Massa (KG-SM) diduga senyawa aktif antioksidan yang terdapat dalam ekstrak etil asetat buah andaliman adalah 2-metoksi-4-vinilfenol.

Andaliman fruit, (Zanthoxylum acanthopodium DC), is widely consumed by people as a food spice and traditional medicine to treat stomach pain, tonic, and as anti-microbial drugs. This study aimed to identify compounds that wereefficacious as antioxidants of andaliman fruit extract. The extraction was performed by kinetic maceration method using n-hexane and ethyl acetate. Then, the crude was tested for its antioxidant activity by free radical DPPH scavenging method. Vitamin C was used as a positive control. Furthermore, the extract was purified by column chromatography to obtain isolate EA.X.6.1 which has the highest antioxidant activity. The results of evaluation on antioxidant activity by free radical DPPH (1,1-difenil-2-pikrilhidrazil)scavenging method showed that ethyl acetate andaliman fruit extract revelaed antioxidant activity with IC50value of 66,91 bpj and isolate EA.X.6.1 which showed the highest antioxidant activity with IC50value of 135,58 bpj. Based on analysis using UV-Vis spectrophotometer, spectrophotometer Fourier Transform Infra Red (FT- IR) and Gas Chromatography- Mass Spectrophotometry (GC-MS), it was considered that antioxidant chemical active compound in ethyl acetate andaliman fruit extract was 2-methoxy-4-vinylphenol
Aktivitas Analgetik Ekstrak Etanol Daun Pugun Tanoh (Picria Fel-Terrae Lour) Pada Mencit (Mus Musculus)
Authors: Yuandani Yuandani , Yohana Martha , Marianne Marianne 
Published: January 2019

Pugun Tanoh (Picria fel-terrae Lour) telah digunakan dalam pengobatan tradisional untuk mengatasi sakit perut dan inflamasi. Kajian ilmiah perlu dilakukan untuk membuktikan khasiat pugun tanoh tersebut khususnya sebagai analgetik. Pengujian aktivitas analgetik ekstrak etanol daun P. fel-terrae dilakukan menggunakan metode plantar tes infrared. Analisis dilakukan dengan membandingkan waktu yang dibutuhkan hewan uji untuk menahan induksi panas dari infrared (IR) pada panjang gelombang 96 nm, setelah pemberian ekstrak dengan dosis 25, 50 dan 100 mg/kg bb. Morfin 10 mg/kg bb dan antalgin 300 mg/kg bb digunakan sebagai kontrol positif. Kelompok kontrol negatif hanya menerima CMC-Na 0,5%. Pengamatan dilakukan selama 90 menit. Ekstrak etanol daun P. fel-terrae menunjukkan efek analgetik jika dibandingkan dengan kelompok kontrol negatif (P>0.05). Nilai AUC (Area Under Curve) waktu respon terhadap nyeri semakin tinggi dengan meningkatnya dosis. Ekstrak pada dosis 100 mg/kg bb menunjukkan aktivitas paling tinggi dengan efek analgetik yang lebih baik dari antalgin 300 mg/kg bb (p < 0,05) tetapi memiliki efek analgetik yang sama dengan morfin 10 mg/kg bb (p > 0,05). Ekstrak etanol daun P. fel-terrae mempunyai efek analgetik dan berpotensi untuk dikembangkan menjadi fitofarmaka.

Pugun Tanoh (Picria fel-terrae Lour) has been used in folk medicine for the treatment of stomach ache and inflammation. The scientific study needs to be done to prove the activity of pugun tanoh especially as analgesic. The evaluation of analgesic activity of ethanol extract of pugun tanoh leaves was conducted using plantar-test infra red method. Analysis was perfomed by comparing the the duration of test animals to resist heat induction from infrared (IR) at a wavelength of 96 nm after being treated with extract at doses of 25, 50 dan 100 mg/kg bw. Morphine 10 mg/kg bwand antalgin 300 mg/kg bwwere used as positive control. Control negative group only received 0.5% Na CMC. The observation was performed for 90 minutes. The ethanol extract of pugun tanoh leaves showed analgesic effect as compared to negative control group (P<0.05). AUC (Area Under Curve) value of duration to resist pain increased as the dose increased. The extract at dose of 100 mg/kg bw displayed higher analgesic activitythan antalgin 300 mg/kg bw (p < 0,05) but was comparable with morphine10 mg/kg bw (p > 0,05). The ethanol extract of P. fel-terraeleaf possesses analgesic activity and thus can be developed into phytopharmaca
Pengaruh Formula Jamu Hiperglikemia Pada Quality Of Life Pasien di Klinik Saintifikasi Jamu Tawangmangu
Authors: Triyono Agus , Astana Widhi , Novianto Fajar 
Published: January 2019

Diabetes mellitus (DM) merupakan penyakit degenerative dengan murbiditas dan mortalitas yang terus meningkat. Herbal medicine telah banyak digunakan untuk mengontrol kadar glukosa darah (KGD) pasien DM. Penelitian ini bertujuan untuk menganalisis efek penggunaan ramuan jamu hiperglikemia terhadap kualitas hidup atau quality of life (QoL) pasien DM. Penelitian ini merupakan studi kohort dengan menggunakan kuesioner Short Form-36 (SF-36) sebagai alat pengukuran kualitas hidup 40 subjek penelitian dengan KGD sewaktu 200 – 300 mg/dl. Pasien diberi ramuan jamu temulawak ,kunyit, dan meniran tiga kali sehari selama 56 hari. Kualitas hidup subjek diukur pada hari ke 0, 28, dan 56. Pengaruh penggunaan jamu terhadap QoL dianalisis menggunakan uji t berpasangan.Sebanyak 58% dari subjek penelitian adalah perempuan. Hasil penelitian membuktikan terdapat perbedaan yang signifikan antara QoL sebelum dan setelah pemberian jamu selama 56 hari, (p=<0,05). Ramuan jamu batang brotowali, herba sambiloto, rimpang temulawak, rimpang kunyit, dan herba meniran dapat meningkatkan QoL pasien DM.

Diabetes mellitus (DM) is a degenerative disease with increased morbidity and mortality. Herbal medicine has been widely used to control blood glucose levels in DM patients. This study aimed to analyze the effect of consumehyperglycemic jamu formula on quality of life (QoL) in DM patients. This study was a cohort study using a Short Form-36 (SF-36) questionnaire as a quality of life measurement tool of 40 subjects with blood gluces levels at 200 - 300 mg / dl. The patient received a jamu fomula of ginger, turmeric, and meniran three times a day for 56 days. The quality of life of the subjects was measured on days 0, 28 and 56. The effect of the admintration of jamu on QoL was analyzed using paired t test. A total of 58% of the research subjects were women.
The results showed that there were significant differences of QoL before and after administration of jamu for 56 days (p = <0.05). Jamu formlua of brotowali stems, bitter herbs, curcuma rhizomes, turmeric rhizomes, and meniran herbs can increase the QoL of DM patients
Vancomycin MIC Distribution among Methicillin-Resistant Staphylococcus Aureus. Is Reduced Vancomycin Susceptibility Related To MIC Creep?
Authors: Othman Hala B. , Abdel Halim Rania M. , Gomaa Fatma Alzahraa M. , Amer Malaka Z. 
Published: January 2019

AIM: To determine the distribution of vancomycin MIC and the frequency of S. aureus strains with reduced vancomycin susceptibility among Methicillin-Resistant Staphylococcus aureus (MRSA) isolates.
METHODS: MRSA isolates (n = 100) were tested for reduced susceptibility to vancomycin using MIC broth microdilution method (BMD), vancomycin screening agar with different vancomycin concentrations with and without casein, and Vitek 2 system.
RESULTS: BMD detected (22%) vancomycin-intermediate S. aureus (VISA) and (78%) vancomycin-susceptible S. aureus (VSSA) but couldnâ€™t detect nine (Heterogeneous VISA) (hVISA) isolates (9%) with MIC â‰¤ 2 Âµg/ml that grew on screening agar 4 Âµg/ml or 6 Âµg/ml. Adding casein to vancomycin screening agar increased detection rate of VISA by 4.5%. Screening agar with 6 Âµg/ml vancomycin overall detection rate for VISA was 95.45%. Probable â€˜pre-hVISAâ€™isolates (17%) showed growth on vancomycin screening agar 2 Âµg/ml with casein. Vitek 2 system failed to detect any VISA isolates.
CONCLUSION: Vancomycin screening agar; 2 Âµg/ml and (4 and 6 Âµg/ml) were able to detect; probable â€œpre hVISA and (hVISA and VISA) isolates respectively based on their BMD MIC values. Decreased vancomycin susceptibility in MRSA isolates might be related to MIC creep. Analysis of vancomycin MIC values over longer periods is recommended to further study this phenomenon and its impact on vancomycin treatment failure.

ABSTRACT
Aims: Determine the distribution of vancomycin MIC and the frequency of S. aureus strains with reduced vancomycin susceptibility among MRSA isolates.
Methods: MRSA isolates (n =100) were tested for reduced susceptibility to vancomycin using MIC broth microdilution method(BMD), vancomycin screening agar with different vancomycin concentrations with and without casein, and Vitek 2 system.
Results: BMD detected (22%) vancomycin intermediate S. aureus(VISA) and (78%) vancomycin susceptible S. aureus(VSSA) but failed to detect nine (Heterogeneous VISA) (hVISA) isolates (9%) with MIC â‰¤2ug/ml that grew on screening agar 4ug/ml or 6 ug/ml. Adding casein to vancomycin screening agar increased detection rate of VISA by 4.5%. Screening agar with 6 ug/ml vancomycin over all detection rate for VISA was 95.45%. Probable â€˜pre-hVISAâ€™isolates (17%) showed growth on vancomycin screening agar 2Âµg/ml with casein. Vitek 2 system failed to detect any VISA isolates.
Conclusion: vancomycin screening agar; 2 Âµg/ml and (4 and 6 Âµg/ml) were able to detect; probable â€œpre hVISA and (hVISA and VISA) isolates respectively based on their BMD MIC values. Decreased vancomycin susceptibility in MRSA isolates might be related to MIC creep. Analysis of vancomycin MIC values over longer periods of time is recommended to further study this phenomenon and its impact on vancomycin treatment failure.
A Retrial Queueing model with FDL at OBS core node
Authors: Dang Thanh Chuong , Pham Duc Trung , Doan Van Thang 
Published: January 2019

Optical Burst Switching networks are considered as an important candidate for the future transport networks. Many analysis models of OBS node with FDLs have been proposed recently. In this paper, we propose a novel retrial queueing model at OBS core node architecture SPL - feed-forward. Blocking probability will be calculated based on Markov multi-dimensional models. Numerical solution values from the proposed analysis method are compared with simulation, as well as between these models.
Complication–simplification spiral in hygrothermal research
Authors: Hokoi Shuichi 
Published: January 2019

AbstractThe author reviewed reported studies related to his own hygrothermal research. The outline of the research is first described with respect to the thermal conductivity of a moist porous material, linearity and nonlinearity, extension of research object, and human thermal physiology and psychology, followed by the lessons learned from these studies. Finally, some proposals for future studies are provided, based on the obtained knowledge. This review is based on a spiral development of thought in an ideal direction, that is, a simplification–complication spiral.
Calculus and survivorship in medieval London: The association between dental disease and a demographic measure of general health
Authors: Yaussy Samantha L. , DeWitte Sharon N. 
Published: January 2019

AbstractObjectivesDental plaque is associated with a variety of systemic diseases and mortality risks in living populations. However, bioarchaeologists have not fully investigated the mortality risks associated with plaque (or its mineralized form, calculus) in the past. This study examines the relationship between survivorship and calculus in a medieval skeletal sample.Materials and methodsOur sample (n = 1,098) from four medieval London cemeteries, c. 1000–1540 CE, includes people who died under attritional (normal) and catastrophic (famine and plague) conditions. The associations between age and the presence of dental calculus on the permanent left first mandibular molar are assessed using binary logistic regression and Kaplan–Meier survival analysis.ResultsThe regression results indicate a significant negative relationship between age and calculus presence for individuals of all ages who died under normal mortality conditions and for adults who died under both normal and catastrophic conditions. Survival analysis reveals decreased survivorship for people of all ages with calculus under normal mortality conditions. Similarly, during conditions of catastrophic mortality, adult males with calculus suffered reduced survivorship compared to males without it, though there was no difference in survivorship between adult females with and without calculus.ConclusionsThese results suggest that, as in modern populations, calculus accumulation in the inhabitants of medieval London reflects a greater risk of premature death. The evaluation of calculus, a potential measure of underlying frailty, in the context of a demographic measure of general health suggests that it might provide insights into health in past populations.
Unusual Attractive Au–π Interactions in Small Diacetylene‐Modified Gold Clusters
Authors: Iwasaki Mitsuhiro , Shichibu Yukatsu , Konishi Katsuaki 
Published: January 2019

AbstractIt is well known that alkynes act as π‐acids in the formation of complexes with metals. We found unprecedented attractive Au–π interactions in diacetylene‐modified [core+exo]‐type [Au8]4+ clusters. The 4‐phenyl‐1,3‐butadiynyl‐modified cluster has unusually short Au–Cα distances in the crystal structure, revealing the presence of attractive interactions between the coordinating C≡C moieties and the neighboring bitetrahedral Au6 core, which is further supported by IR and NMR spectra. Such weak interactions are not found in mono‐acetylene‐modified clusters, which indicates that they are specific for diacetylenic ligands. The attractive Au–π interactions are likely associated with the low energy of the π* orbital in the diacetylenic moieties, into which the valence electrons of the gold core may be back donated. The [Au8]4+ clusters show clear red‐shifts of >10 nm with respect to the corresponding mono‐acetylenic clusters in UV/Vis absorption bands, which indicates substantial electronic perturbation effects of the Au–π interactions.
Polybismuthide Anions as Ligands: The Homoleptic Complex [(Bi7)Cd(Bi7)]4− and the Ternary Cluster [(Bi6)Zn3(TlBi5)]4−
Authors: Lichtenberger Niels , Massa Werner , Dehnen Stefanie 
Published: January 2019

AbstractWe present the results from a reactivity study of the binary anion (TlBi3)2− towards Group 12 metal compounds MPh2 (M=Zn, Cd, Hg) to gain access to coordination compounds of polycyclic polypnictide molecules such as Bi73− or Bi113−. The coordination chemistry of these polybismuthide cages has been unprecedented to date, while it has been known for a long time for the lighter Group 15 anions Pn73− (Pn=P, As, Sb). The use of (TlBi3)2−, previously shown to release Tl under certain conditions in situ, resulted in the formation of the first heterometallic polyanion in which a nortricyclane‐type polybismuthide coordinates a transition‐metal atom, [(Bi7)Cd(Bi7)]4−. Reactions with the lighter Group 12 metal precursor yielded the uncommon ternary cluster [(Bi6)Zn3(TlBi5)]4−, most likely representing a reaction intermediate, and at the same time hinting at the formation of the nortricyclane‐shaped cage. Quantum‐chemical studies provide deeper insight into the stability trends of the [(E7)M(E7)]4− anion family and reveal a complex bonding situation in [(Bi6)Zn3(TlBi5)]4−, which features both localized and multi‐center bonding.