bluuebunny/crossref_metadata_2025_split huggingface dataset:
Intravital microscopy of collective invasion plasticity in breast cancer
Authors: Ilina Olga , Campanello Leonard , Gritsenko Pavlo G. , Vullings Manon , Wang Chenlu , Bult Peter , Losert Wolfgang , Friedl Peter 
Published: July 2018

ABSTRACT
Cancer invasion programs are adaptive by switching between metastatic collective and single-cell dissemination; however, current intravital microscopy models for epithelial cancer in mice fail to reliably recreate such invasion plasticity. Using microimplantation of breast cancer spheroids into the murine mammary fat pad and live-cell monitoring, we show microenvironmental conditions and cytoskeletal adaptation during collective to single-cell transition in vivo. E-cadherin-expressing 4T1 and E-cadherin-negative MMT tumors both initiated collective invasion along stromal structures, reflecting invasion patterns in 3D organotypic culture and human primary ductal and lobular carcinoma. Collectively invading cells developed weakly oscillatory actin dynamics, yet provided zones for single-cell transitions with accentuated, more chaotic actin fluctuations. This identifies collective invasion in vivo as a dynamic niche and efficient source for single-cell release.
Understanding alcohol-related liver disease patients' illness beliefs and views about their medicine
Authors: Presky Jonathan , Webzell Ian , Murrells Trevor , Heaton Nigel , Lau-Walker Margaret 
Published: July 2018

Background: people with alcohol-related liver disease require complex treatment plans that often include the need for medication for the rest of their lives. Between 30% and 50% of all patients do not take their treatment as prescribed, leading to a significantly increased risk of morbidity and mortality. Aim: to consider the factors which influence beliefs held by patients with alcohol-related liver disease about their medication to provide an evidence base to support interventions to reduce medication non-adherence. Method: an observational cross-sectional patient survey. Results: statistically significant associations were found between positive attitudes towards medication and the illness representation dimensions of ‘illness identity’ and ‘illness comprehension’. Conclusions: medication adherence in patients with alcohol-related liver disease is likely to be improved by an intervention that strives to improve the patient's understanding of their illness condition and their perception of their illness symptoms.
Effects of pruning on growth and yield of cucumber (Cucumis sativus) Mercy variety in The acid soil of North Kalimantan, Indonesia
Authors: MARDHIANA MARDHIANA , PRADANA ANKARDIANSYAH PANDU , ADIWENA MUH. , KARTINA KARTINA , SANTOSO DWI , WIJAYA RIZZA , MALIKI ANAS 
Published: July 2018

Mardhiana, Pradana AP, Adiwena M, Kartina, Santoso D, Wijaya R, Maliki A. 2017. Effects of pruning on growth and yield of cucumber (Cucumis sativus) Mercy variety in The acid soil of North Kalimantan, Indonesia. Cell Biol Dev 1: 13-17. In recent years, cucumber production in Tarakan, North Kalimantan only reaches 20 tons ha-1. In fact, cucumber production potential could reach 49 tons ha-1. Several factors that limit the low productivity of cucumbers in Tarakan are acid soil and cultivation techniques which are still limited. This study aimed to determine the effect of pruning on the growth and yield of cucumbers in acid soil in Tarakan. The study was conducted using Randomized Complete Block Design with the treatment of without pruning (P0), shoot of prunings on the main stem (P1), pruning of whole lateral branches above the third section (P2), and pruning of 2 lateral branches that emerged first above the third section (P4). The results showed that plant height was 16.17% (P1) and 2.26% (P2) lower also 0.13% higher (P3) than the control (P0). The highest number of leaves was found in treatment P1 (16.19%) compared to P0. The best fruit diameter was also found in P1 treatment with 4.93% difference compared to P0. Furthermore, a highly significant and the best result on weight per fruit were also obtained by P1 treatment. The results showed that the fruit weight of P1 treatment (11.39%) was higher than P0. This study provided new information that the pruning treatment of shoots on the main stem of cucumber variety Mercy in acid soil could increase the diameter and weight of cucumber.
Toxicity of Randia nilotica fruit extract on Schistosoma mansoni, Biomphalaria pfeifferi and Bulinus truncatus
Authors: EBODI ALADDIN YOUSIF ELTEIB , AHMED MOHAMMED MAGZOUB 
Published: July 2018

Ebodi AYE, Ahmed MM. 2017. Toxicity of Randia nilotica fruit extract on Schistosoma mansoni, Biomphalaria pfeifferi and Bulinus truncatus. Cell Bio Dev 1 (1): 23-30. The aqueous filtered and unfiltered extract of the fruits of Randia nilotica (locally name as Shagarat El-Murfaein) were assessed as molluscicides against Biomphalaria pfeifferi and Bulinus truncatus as well as their effect on cercariae and miracidia of Schistosoma mansoni. The plant was tested on uninfected B. pfeifferi and B. truncatus, the results showed that unfiltered extracts were found relatively more potent than filtered one (i.e. 100% was attained at 90 ppm and 80 ppm) respectively. While, filtered extract tested on uninfected B. pfeifferi and B. truncatus (100% was attained at 100 ppm and 90 ppm) respectively. The effect of unfiltered extract on infected B. pfeifferi produced 100% mortality in concentration of 70 ppm. The activity of the plant on cercariae and miracidia revealed that cercariae was more resistance than miracidia (i.e.50 ppm killed all cercariae within 3 hours while killed miracidia within 2 hours. The results were statistically analyzed and discussed, and the findings were promising and could open new avenues for the practical use of the plant at the field.
Modern Approaches to the Diagnosis and Management of Children With Primary Ciliary Dyskinesia
Authors: Baranov A. A. , Namazova-Baranova L. S. , Vishneva E. A. , Selimzyanova L. R. , Simonova O. I. , Sereda E. V. , Rozinova N. N. , Tzygina E. N. , Katosova L. K. , Lazareva A. V. , Gorinova Yu. V. , Kustova O. V. 
Published: July 2018

The article presents the most modern positions of healthcare delivery for children with primary ciliary dyskinesia. Symptoms of this pathology in clinical practice vary that is conditioned by genetic heterogeneity of the disease. The most common disease manifestation in children is frequent inflammatory diseases of the upper and lower respiratory tract. They are recorded in most patients, especially in young children, and the diagnosis is often determined untimely due to a low awareness of specialists about this nosology. Differential diagnostic approach is described in detail, peculiarities of treatment and management of children with this nosology are specified. The material is based on clinical guidelines developed and approved by the professional association «Union of Pediatricians of Russia».
Acute Abdominal Pain in Children: Causes and Development Factors
Authors: Romanova E. A. , Namazova-Baranova L. S. , Dyakonova E. Yu. , Romanov A. Yu. , Mezhidov K. S. , Dokhshukaeva Z. I. 
Published: July 2018

Currently differential diagnosis of acute abdominal pain syndrome in children at prehospital care units is vital and urgent problem which requires solution. Unfortunately, embarrassing mistakes are still followed by late or inadequate treatment and complications as a result. The problem solution requires both medical stuff alert and diagnosis algorithm revision and improvement. Improvement of technical equipment and availability of instrumental diagnostic methods at the out-hospital settings is a pressing need. The article provides a classification, detailed pathogenesis, and clinical presentation of acute abdominal pain in children under different nosologies (therapeutic and surgical). We considered the problem of adequate differential diagnosis of acute abdominal pain in children when the diagnostics is performed by primary care physicians and specialists of emergency medical services at the prehospital stage.
Sosyal Medya Kullanımının İletişim Kaygısı Bağlamında Değerlendirilmesi
Authors: TAMER GENCER Zekiye 
Published: July 2018

Bu çalışmanın temel amacı, son yıllarda epeyce yoğun bir
kullanıcı kitlesine ulaşmış olan sosyal medya araçlarını kullanan bireylerin,
kendilerini ifade etme ve diğer bireylerle etkileşim kurma, kurulan
iletişimdeki kaygıları açısından incelemektir. Dünyada olduğu gibi Türkiye’de
de yoğun bir kitle tarafından kullanılan sosyal araçların yüz yüze iletişimin
kısmen önüne geçmiş olması, bu araçlar üzerinden kaygı incelenmesine neden
olmuştur. Çalışmada sosyal medyanın tarihi gelişim sürecine yer verilmiş ve kavramsal
olarak kaygı ve iletişim kaygısı tanımlanmıştır.

Araştırmada, yaşları 18 ile 25 arasında değişen, üniversite
öğrencilerinden oluşan bir grup ile anket yöntemi kullanılmıştır. McCroskey
(1982) tarafından geliştirilen ve Dünya’da birçok araştırmacı tarafından da
kullanılan “İletişim Kaygısı Ölçeği” ilgili öğrenci grubuna uygulanmıştır.

Anket içeriğinde katılımcıların sosyal ağları kullanma biçim,
neden ve sıklıkları ile bu ağlardaki etkileşimlerinde duydukları iletişim kaygı
düzeylerine dair sorular yer almıştır. Bireylerin yüz yüze iletişim yerine
tercih ettikleri sosyal medya iletişiminin kaygı düzeyleri ile ilişkisinin
ölçülmesi amaçlanmıştır. Tüm katılımcılardan onay alınmış ve onayları
doğrultusunda demografik bilgilerine de ulaşılmıştır. Araştırma bulguları SPSS
programı ile analiz edilerek gerekli sonuçlara ulaşılmıştır. Bu çalışma
sonuçlarına göre, cep telefonu ve akıllı cihaz sahipliği son derece yüksek bir
orandadır (98,1). Ayrıca sosyal medya ortamlarına erişebilmek için gerekli olan
internete bağlanma da çoğunlukla bu cihazlar üzerinden sağlanmaktadır
(%39,1). Bir çok amaç için kullanılan
sosyal medya ortamlarında geçirilen sürenin de çoğunlukla iki saat ve daha
fazla olduğu göz önüne alındığında bireylerin bu özgür ve rahat iletişim
ortamlarına daha çok ilgi gösterdikleri aşikardır. Demografik özellikler
açısından öğrencilerin sosyal medya üzerinden kurdukları iletişimde kaygı
düzeyleri arasında anlamlı farklılıklar olmaması sosyal medyadaki eylemleri
daha sık ve aktif hale getirmektedir. İletişim kaygısı ölçeğinde (51-120 puan
aralığı) ortalama puanın 72,21 olması sosyal medya iletişimin kaygı düzeyini
yükseltmediğini göz önüne sermektedir. Bu durum da sosyal medya üzerinden her
konuda bilgi ve fikir paylaşımının artmasını sağlamaktadır.
The Effect of Transformational Leadership, Self Efficacy and Self Learning toward Lecturers Job Performance at STAIN Curup Rejang Lebong Regency of Bengkulu Province
Authors: Warlizasusi Jumira , Supriyati Yetti , Karnati Neti 
Published: July 2018

This research aims to analyze direct effect of transformational leadership, self efficacy and self learning toward lecturers Job performance at STAIN Curup. This research is newest research by using research model about lecturer’s performance which was surveyed from the effect of transformational leadership (indicators: effectiveness, productivity and usefulness), self efficacy factors (indicators: mobilize motivation, cognitive resource, job difficulty level and attitude selection), and self learning (indicators: self assesment, self improvment and self reinforcement). This research used quantitative approach with survey method and path analysis technique. Population was 96 civil servant lecturers. Findings of the research showed that there is a positive effect of transformational leadership toward lecturer’s job performance with value of 0.2390, positive effect self efficacy and lecturers job performance with value of 0.3040 and positive effect of self-learning torward lecturers job performance with value of 0.2720, there is also dirrect effect of transformational leadership toward self learning with value of 0.2740, self efficacy toward self learning with value of 0.4920, and transformational leadership toward self efficacy with value of 0.2670.
Pendampingan Implementasi Kurikulum 2013 untuk Peningkatan Mutu Pembelajaran Guru-guru (POKJA RA) Poncol di Magetan
Authors: Mukhibat Mukhibat , Fitri Noor Faizatul , Hartati Afiatun Sri 
Published: July 2018

The lack of assistance to the RA Working Group (POKJA RA) Poncol in the implementation of Curriculum 2013, causing the implementation of can not be realized. Base on this, the teachers of RA in sub-district Poncol Magetan urgently require the empowernent in the form at training/assistance continously so that the teacher are able and understand the lgic of preparation of leraning tool according to K-13, the are at least four inportance change of this devotion program, i.e: 1) teacher can fulfil their duties and responsibilities in creating a scientific, creative, and meaningful learning. 2) the emergence of awarness that the development of leraning resourches becames imperative, this is proven by the succesfull communication built with Perpusda Magetan which has never been thought of at all. 3) PTK material has raised awareness and and understanding that improvement in learning should always be done by teacher so that the learning problem that have been faced found the way out. 4) teachers at POKJA RA Poncol have on Permendikbud RI No. 146 year 2014 about K-13 PAUD.
An Embodied Conversational Agent for Unguided Internet-Based Cognitive Behavior Therapy in Preventative Mental Health: Feasibility and Acceptability Pilot Trial
Authors: Suganuma Shinichiro , Sakamoto Daisuke , Shimoyama Haruhiko 
Published: July 2018

Background
Recent years have seen an increase in the use of internet-based cognitive behavioral therapy in the area of mental health. Although lower effectiveness and higher dropout rates of unguided than those of guided internet-based cognitive behavioral therapy remain critical issues, not incurring ongoing human clinical resources makes it highly advantageous.

Objective
Current research in psychotherapy, which acknowledges the importance of therapeutic alliance, aims to evaluate the feasibility and acceptability, in terms of mental health, of an application that is embodied with a conversational agent. This application was enabled for use as an internet-based cognitive behavioral therapy preventative mental health measure.

Methods
Analysis of the data from the 191 participants of the experimental group with a mean age of 38.07 (SD 10.75) years and the 263 participants of the control group with a mean age of 38.05 (SD 13.45) years using a 2-way factorial analysis of variance (group × time) was performed.

Results
There was a significant main effect (P=.02) and interaction for time on the variable of positive mental health (P=.02), and for the treatment group, a significant simple main effect was also found (P=.002). In addition, there was a significant main effect (P=.02) and interaction for time on the variable of negative mental health (P=.005), and for the treatment group, a significant simple main effect was also found (P=.001).

Conclusions
This research can be seen to represent a certain level of evidence for the mental health application developed herein, indicating empirically that internet-based cognitive behavioral therapy with the embodied conversational agent can be used in mental health care. In the pilot trial, given the issues related to feasibility and acceptability, it is necessary to pursue higher quality evidence while continuing to further improve the application, based on the findings of the current research.
Female unemployment and its determinants in Poland in 2016 from the spatial perspective
Authors: Lewandowska-Gwarda Karolina 
Published: July 2018

Research background: Through the cultural progress and socio-economic development in Poland women have obtained the same rights as men in the labour market. Nevertheless, they continuously face discrimination and the difficulty, resulting from their traditional role, in finding or maintaining employment.
Purpose of the article: The main objective of this study was an analysis of female unemployment and its determinants in Poland in 2016 from the spatial perspective. The following research questions were also specified: Is female unemployment dependent on social factors (do they play the key role)? Are the factors determining the level of female unemployment spatially diversified? Is the GWR model an effective tool in analysis of female unemployment?
Methods: The research applied GIS and spatial analysis methods including Geographically Weighted Regression, which enables the identification of the variability of regression coefficients in the geographical space. The analysis was carried out based on statistical data presenting the share of unemployed women in the working age population for 380 Polish districts (NUTS 4, LAU 1) in 2016.
Findings & Value added: The research results showed that in the period 2003-2016 the female unemployment was getting lower, but it was still higher than men. It was also spatially diversified. Moreover, the determinants of female unemployment were diverse in the geographic space and did not have a significant impact on the variable in all spatial units. The existence of clusters of districts, characterised by similar interactions and its strength, was also confirmed. The results of this analysis proved that non-economic (social) factors largely affected the level of female unemployment in Poland in 2016. Using GWR enabled drawing detailed conclusions concerning the determinants of female unemployment in Poland, it proved to be an effective tool for the analysis of this phenomenon.
Corrosion of metals in zinc nitrate hexahydrate and calcium chloride hexahydrate
Authors: Oravcová Kristína , Danielik Vladimír 
Published: July 2018

Abstract
Materials used for heat accumulation are substances with the phase change at temperatures below 80 °C. In such substances, a high amount of energy can be stored due the phase change. Because of possible corrosion of the heat container components, it is necessary to know their resistance in the given medium. In this work, the corrosion of aluminum, copper and carbon steel was studied in two liquid media: zinc nitrate hexahydrate and calcium chloride hexahydrate. Corrosion tests have shown that steel is the least resistant to corrosion in both media. Aluminum has been proved as the most durable material in zinc nitrate hexahydrate media. On the other hand, pitting corrosion on aluminum occurred in the calcium chloride hexahydrate making it unsuitable for the use in this media. From the comparison of two studied PCMs follows that zinc nitrate hexahydrate is a more aggressive medium in comparison with calcium chloride hexahydrate. From the point of view of corrosion, zinc nitrate hexahydrate is not suitable for heat accumulation when using the studied metals. When using the calcium chloride hexahydrate as PCM, copper is suitable as a construction material; aluminum and carbon steel show pitting corrosion.
An Outbreak of Human Trichinellosis in the Village of Subotinac near the Town of Aleksinac
Authors: Popović-Dragonjić Lidija , Kocić Ilija 
Published: July 2018

Abstract
An outbreak of trichinellosis affecting 13 individuals, of whom 8 with severe form presented as myocarditis, occurred in the village of Subotinac near the town of Aleksinac in Serbia. The source of this epidemic was smoked pork from a domestic pig that had not undergone meat inspection procedures. The most striking clinical features among all the 13 patients were muscular pain (84.6%), malaise (69.2%), upper eyelid edema (61.5%), and difficulty in chewing (53.9%). These symptoms and signs were associated with significant elevations of creatine phosphokinase and lactate dehydrogenase levels. As high as 61.5% of the patients with trichinellosis were diagnosed with myocarditis (determined by means of electrocardiography, echocardiography, troponin I and creatine kinase-MB measurements). The patients had Trichinella-specific IgG antibodies in an enzyme-linked immunosorbent assay and positive indirect immunofluorescence test results. Patients seemed to respond well to treatment with mebendazole. Corticosteroid therapy was administered to patients with myocarditis. Since high percentage of our patients presented with myocarditis, an infectious diseases specialist should always keep in mind doing cardiac biomarkers analyses, echocardiography and electrocardiography.
Non-target toxicity of novel insecticides
Authors: Mužinić Vedran , Želježić Davor 
Published: July 2018

Abstract
Humans have used insecticides since ancient times. The spectrum and potency of available insecticidal substances has greatly expanded since the industrial revolution, resulting in widespread use and unforeseen levels of synthetic chemicals in the environment. Concerns about the toxic effects of these new chemicals on non-target species became public soon after their appearance, which eventually led to the restrictions of use. At the same time, new, more environmentally-friendly insecticides have been developed, based on naturally occurring chemicals, such as pyrethroids (derivatives of pyrethrin), neonicotinoids (derivatives of nicotine), and insecticides based on the neem tree vegetable oil (Azadirachta indica), predominantly azadirachtin. Although these new substances are more selective toward pest insects, they can still target other organisms. Neonicotinoids, for example, have been implicated in the decline of the bee population worldwide. This review summarises recent literature published on non-target toxicity of neonicotinoids, pyrethroids, and neem-based insecticidal substances, with a special emphasis on neonicotinoid toxicity in honeybees. We also touch upon the effects of pesticide combinations and documented human exposure to these substances.
The Value of Perioperative ECG Recordings in the Cardiovascular Monitoring and Risk Assessment of Asymptomatic Patients with Total Hip Arthroplasty
Authors: Frigy Attila , Szabó-Györke István , Csomor Krisztina , Czédula András , Zuh Sándor-György , Gergely István 
Published: July 2018

Abstract

Aim: To evaluate the value of a more closed perioperative ECG follow-up in the investigation and forecasting of cardiovascular events during and after hospital admission.

Methods: We included in the study 30 asymptomatic patients from cardiac point of view (14 women, 16 men, mean age 63 years), who underwent total hip arthroplasty. ECGs were performed on the day before surgery, on the day of surgery, after the intervention, and on the 3rd day. We looked for the correlations between ECG changes and clinical events.

Results: The commonest postoperative new ECG changes were QTc prolongation (14 patients -46,6%) and sinus tachycardia (8 patients - 26,6%). There were no major cardiac events during hospitalization, and we found possible correlations in two cases between perioperative ST-T changes and postdischarge clinical events: one exitus and one case of ischemic heart disease.

Conclusions: Our data do not support the efficacy of a more closed, routine ECG follow-up in the studied, low risk patient population, but new perioperative ST-T changes always have to be taken into account.
MHD Boundary Layer Flow of Nanofluid Through a Porous Medium Over a Stretching Sheet with Variable Wall Thickness: Using Cattaneo–Christov Heat Flux Model
Authors: Kiran Kumar R.V.M.S.S. , Varma S.V.K. 
Published: July 2018

Abstract
The hydromagnetic nanofluid flow over a stretching sheet in a porous medium with variable wall thickness in the presence of Brownian motion and thermophoresis is investigated. The heat transfer characteristics with variable conductivity are explored by using Cattaneo-Christov heat flux model. The governing non-linear ordinary differential equations are solved by using boundary value problem default solver in MATLAB bvp4c package. The impact of various important flow parameters on velocity, temperature and nanoparticle concentration as well as the friction factor coefficient and the rate of heat and mass transfer coefficients are presented and discussed through graphs and tables. It is found that the fluid velocity is accelerated with an increase in wall thickness parameter for n > 1, while the reverse trend is observed for n < 1.