bluuebunny/crossref_metadata_2025_split huggingface dataset:
Malnutrition in acute heart failure with preserved ejection fraction: clinical correlates and prognostic implications
Authors: Chien Shih‐Chieh , Lo Chi‐In , Lin Chao‐Feng , Sung Kuo‐Tzu , Tsai Jui‐Peng , Huang Wen‐Hung , Yun Chun‐Ho , Hung Ta‐Chuan , Lin Jiun‐Lu , Liu Chia‐Yuan , Hou Charles Jia‐Yin , Tsai I‐Hsien , Su Cheng‐Huang , Yeh Hung‐I , Hung Chung‐Lieh 
Published: August 2019

AbstractAimsThis study aimed to evaluate the prognostic significance of nutritional status in post‐discharge Asians with heart failure with preserved ejection fraction (HFpEF).Methods and resultsWe examined the prognostic implications of body mass index (BMI) and nutritional markers among consecutive patients hospitalized for HFpEF. Nutritional metrics were estimated by serum albumin (SA), prognostic nutritional index (PNI), Controlling Nutritional Status (CONUT) score, and geriatric nutritional risk index. Among 1120 patients (mean age: 77.2 ± 12.6 years, 39.4% men), mean SA levels, PNI, CONUT scores, and geriatric nutritional risk index were 3.3 ± 0.6 g/dL, 40.2 ± 8.7, 5.5 ± 2.1, and 95.9 ± 14.5, respectively. Lean body size, higher white blood cell counts and C‐reactive protein levels, anaemia, and lack of angiotensin blocker use were independently associated with malnutrition (defined by SA < 3.5 g/dL). Higher SA levels [hazard ratio (HR): 0.67 (95% confidence interval, CI: 0.53–0.85)], higher PNI [HR: 0.97 (95% CI: 0.95–0.99)], and higher geriatric nutritional risk index [HR: 0.98 (95% CI: 0.97–0.99)] (all P < 0.05) were all associated with longer survival, with higher CONUT score [HR: 1.08 (95% CI: 1.02–1.13)] exhibited higher mortality in Cox regression models and with higher SA levels/PNI but not BMI further contributing to the reduced rate of re‐hospitalization (both P < 0.05). Categorizing BMI (25 kg/m2 as cut‐off) and nutritional status showed significantly higher mortality rates among patients with lower BMI/malnutrition than among those with BMI/better nutrition (SA level, PNI, and CONUT score, all P < 0.01). Restricted cubic spline regression revealed a marked survival benefit of better nutrition with increasing BMI (adjusted Pinteraction for both SA level and PNI: <0.001; adjusted Pinteraction for CONUT score: 0.046).ConclusionsMalnutrition was frequently and strongly associated with systemic inflammation in Asian patients hospitalized for acute HFpEF. Our findings also indicate that nutrition may play a pivotal role in metabolic protection in this population.
Simultaneous optimization of the acidified water extraction for total anthocyanin content, total phenolic content, and antioxidant activity of blue honeysuckle berries (Lonicera caerulea L.) using response surface methodology
Authors: Li Fengfeng , Zhao Hengtian , Xu Ruiru , Zhang Xiuling , Zhang Wentao , Du Meiling , Liu Xiaochen , Fan Lili 
Published: August 2019

AbstractThe purpose of this study was to optimize the total anthocyanin content (TAC), total phenolic content (TPC), and antioxidant activity of acidified water extract from blue honeysuckle berries by response surface methodology (RSM). The optimized conditions were HCl concentration of 0.35%, liquid–solid ratio of 49.42 ml/g, and extraction temperature of 41.56°C for total anthocyanin content (24.01 ± 0.37 mg/g), total phenolic content (207.03 ± 3.31 mg/g), DPPH radical scavenging activity (68.24 ± 1.13%), and ABTS radical scavenging activity (70.05 ± 0.84%). The experimental results are consistent with the predicted values. The results showed that acidified water extraction was an effective, simple, and green technique for the extraction of total anthocyanins, total phenol, and antioxidant activity from blue honeysuckle berries.
Deletion of the RNA regulator HuR in tumor‐associated microglia and macrophages stimulates anti‐tumor immunity and attenuates glioma growth
Authors: Wang Jiping , Leavenworth Jianmei W. , Hjelmeland Anita B. , Smith Reed , Patel Neha , Borg Ben , Si Ying , King Peter H. 
Published: August 2019

AbstractGlioblastoma is a malignant brain tumor that portends a poor prognosis. Its resilience, in part, is related to a remarkable capacity for manipulating the microenvironment to promote its growth and survival. Microglia/macrophages are prime targets, being drawn into the tumor and stimulated to produce factors that support tumor growth and evasion from the immune system. Here we show that the RNA regulator, HuR, plays a key role in the tumor‐promoting response of microglia/macrophages. Knockout (KO) of HuR led to reduced tumor growth and proliferation associated with prolonged survival in a murine model of glioblastoma. Analysis of tumor composition by flow cytometry showed that tumor‐associated macrophages (TAMs) were decreased, more polarized toward an M1‐like phenotype, and had reduced PD‐L1 expression. There was an overall increase in infiltrating CD4+ cells, including Th1 and cytotoxic effector cells, and a concomitant reduction in tumor‐associated polymorphonuclear myeloid‐derived suppressor cells. Molecular and cellular analyses of HuR KO TAMs and cultured microglia showed changes in migration, chemoattraction, and chemokine/cytokine profiles that provide potential mechanisms for the altered tumor microenvironment and reduced tumor growth in HuR KO mice. In summary, HuR is a key modulator of pro‐glioma responses by microglia/macrophages through the molecular regulation of chemokines, cytokines, and other factors. Our findings underscore the relevance of HuR as a therapeutic target in glioblastoma.
Emotions amplify speaker–listener neural alignment
Authors: Smirnov Dmitry , Saarimäki Heini , Glerean Enrico , Hari Riitta , Sams Mikko , Nummenmaa Lauri 
Published: August 2019

AbstractIndividuals often align their emotional states during conversation. Here, we reveal how such emotional alignment is reflected in synchronization of brain activity across speakers and listeners. Two “speaker” subjects told emotional and neutral autobiographical stories while their hemodynamic brain activity was measured with functional magnetic resonance imaging (fMRI). The stories were recorded and played back to 16 “listener” subjects during fMRI. After scanning, both speakers and listeners rated the moment‐to‐moment valence and arousal of the stories. Time‐varying similarity of the blood‐oxygenation‐level‐dependent (BOLD) time series was quantified by intersubject phase synchronization (ISPS) between speaker–listener pairs. Telling and listening to the stories elicited similar emotions across speaker–listener pairs. Arousal was associated with increased speaker–listener neural synchronization in brain regions supporting attentional, auditory, somatosensory, and motor processing. Valence was associated with increased speaker–listener neural synchronization in brain regions involved in emotional processing, including amygdala, hippocampus, and temporal pole. Speaker–listener synchronization of subjective feelings of arousal was associated with increased neural synchronization in somatosensory and subcortical brain regions; synchronization of valence was associated with neural synchronization in parietal cortices and midline structures. We propose that emotion‐dependent speaker–listener neural synchronization is associated with emotional contagion, thereby implying that listeners reproduce some aspects of the speaker's emotional state at the neural level.
Steady incompressible magnetohydrodynamics Casson boundary layer flow past a permeable vertical and exponentially shrinking sheet: A stability analysis
Authors: Lund Liaquat Ali , Omar Zurni , Khan Ilyas 
Published: August 2019

AbstractSteady incompressible magnetohydrodynamic mixed convection boundary layer flow of a Casson fluid on an exponentially vertical shrinking sheet using the non‐Newtonian heating equation is investigated in this paper. There are three main objectives of this study, namely, to develop a new mathematical model, to obtain multiple solutions, and to perform stability analysis. The governing partial differential equations have been changed into nonlinear ordinary differential equations. The resultant equations of boundary value problems are then converted into the equivalent initial value problems using the shooting method before they can be solved using Runge‐Kutta of order four. The numerical results are obtained and found to be in good agreement with the published literature. The results also indicate that the velocity boundary layer becomes thinner as the magnetic, slip, and Casson parameters increase. Dual solutions for temperature and velocity distributions are obtained. Furthermore, the results suggest that the presence of the force of buoyancy (opposing flow case) would cause the occurrence of dual solutions. However, based on the stability analysis, only the first solution is stable.
Long‐term outcomes and five‐year recurrence‐free survival curves after native‐tissue prolapse repair
Authors: Deo Giuseppe , Bernasconi Davide P. , Cola Alice , Palmieri Stefania , Spelzini Federico , Milani Rodolfo , Manodoro Stefano , Frigerio Matteo 
Published: August 2019

AbstractObjectiveTo evaluate the long‐term objective and subjective outcomes to build recurrence‐free survival curves after mesh‐free uterosacral ligament suspension and to evaluate the long‐term impact of prognostic factors on outcome measures.MethodsA retrospective study analyzed 5‐year follow‐up after repair of primary prolapse through high uterosacral ligament suspension. Bulging symptoms and post‐operative prolapse stage II or above were considered subjective and objective recurrences, respectively. The cumulative proportion of relapse‐free patients in time was analyzed by Kaplan‐Meier curves.ResultsA total of 353 women were analyzed. Five‐year recurrence rates were 15.0% for objective recurrence, 13.0% for subjective recurrence, and 4.0% for the combined objective and subjective recurrences. Premenopausal status was shown to be a risk factor for anatomic (P=0.022), symptomatic (P=0.001), and combined (P=0.047) recurrence. Conversely, anterior repair was shown to be a protective factor for symptomatic (P=0.012) and combined (P=0.002) recurrence. Most of the recurrences occurred within 2 years after surgery.ConclusionLong‐term outcomes after high uterosacral ligament suspension were satisfactory. Premenopausal status and lack of anterior repair represented risk factors for recurrence in the long term.
A derivatives trading recommendation system: The mid‐curve calendar spread case
Authors: Koshiyama Adriano S. , Firoozye Nikan , Treleaven Philip 
Published: August 2019

SummaryDerivative traders are usually required to scan through hundreds, even thousands of possible trades on a daily basis. Up to now, not a single solution is available to aid in their job. Hence, this work is aimed to develop a trading recommendation system, and to apply this system to the so‐called Mid‐Curve Calendar Spread (MCCS) trade. To suggest that such approach is feasible, we used a list of 35 different types of MCCSs; a total of 11 predictive and 4 benchmark models. Our results suggest that linear regression with l1‐regularisation (Lasso) compared favourably to other approaches from a predictive and interpretability point of views.
Effects of substrate patterning on cellular spheroid growth and dynamics measured by gradient light interference microscopy (GLIM)
Authors: Fanous Michael J. , Li Yanfen , Kandel Mikhail E. , Abdeen Amr A. , Kilian Kristopher A. , Popescu Gabriel 
Published: August 2019

AbstractThe development of three‐dimensional (3D) cellular architectures during development and pathological processes involves intricate migratory patterns that are modulated by genetics and the surrounding microenvironment. The substrate composition of cell cultures has been demonstrated to influence growth, proliferation and migration in 2D. Here, we study the growth and dynamics of mouse embryonic fibroblast cultures patterned in a tissue sheet which then exhibits 3D growth. Using gradient light interference microscopy (GLIM), a label‐free quantitative phase imaging approach, we explored the influence of geometry on cell growth patterns and rotational dynamics. We apply, for the first time to our knowledge, dispersion‐relation phase spectroscopy (DPS) in polar coordinates to generate the radial and rotational cell mass‐transport. Our data show that cells cultured on engineered substrates undergo rotational transport in a radially independent manner and exhibit faster vertical growth than the control, unpatterned cells. The use of GLIM and polar DPS provides a novel quantitative approach to studying the effects of spatially patterned substrates on cell motility and growth.
Parallelized shifted‐excitation Raman difference spectroscopy for fluorescence rejection in a temporary varying system
Authors: Shimada Rintaro , Nakamura Takashi , Ozawa Takeaki 
Published: August 2019

AbstractA fluorescence background is one of the common interference factors of the Raman spectroscopic analysis in the biology field. Shifted‐excitation Raman difference spectroscopy (SERDS), in which a slow (typically 1 Hz) modulation to excitation wavelength is coupled with a sequential acquisition of alternating shifted‐excitation spectra, has been used to separate Raman scattering from excitation‐shift insensitive background. This sequential method is susceptible to spectral change and thus is limited only to stable samples. We incorporated a fast laser modulation (200 Hz) and a mechanical streak camera into SERDS to effectively parallelize the SERDS measurement in a single exposure. The developed system expands the scope of SERDS to include temporary varying system. The proof of concept is demonstrated using highly fluorescent samples, including living algae. Quantitative performance in fluorescence rejection and the robustness of the method to the dynamic spectral change during the measurement are manifested.
Optimization of infusional calcium gluconate for prevention of hypocalcemic reactions during therapeutic plasma exchange
Authors: Zhao Yong , Garrity Danielle , Graves Molly , Linden Jeanne , St. Pierre Patricia , Ducharme Paula , Greene Mindy , Vauthrin Michelle , Weinstein Robert 
Published: August 2019

AbstractWe sought to optimize direct intravenous infusion of calcium gluconate (CaGlu) for maintaining plasma ionized calcium concentration ([Ca2+]) and preventing hypocalcemic reactions during 34 consecutive 1‐volume therapeutic plasma exchanges (TPEs) in eight patients. CaGlu, 2 g in 50 mL of 0.9% NaCl, was prepared by our hospital pharmacy and infused at either 1.0 or 1.6 g/h during alternate TPE. Plasma [Ca2+] was monitored at intervals of 20 to 30 minutes. At 1 g/h of CaGlu, plasma [Ca2+] fell by 8.35% after 40 to 50 minutes and then plateaued. At 1.6 g/h of CaGlu, plasma [Ca2+] fell by 6% after 20 to 30 minutes and then plateaued. The difference at 40 to 50 minutes was significant (P = .015). Hypocalcemic reactions were noted in three patients during 5 of 17 TPE at 1.0 g/h (all after 40 to 60 minutes) but 0 of 17 TPE at 1.6 g/h (P = .044). CaGlu at 1.6 g/h stabilized plasma [Ca2+] and appears to prevent hypocalcemic reactions during TPE.
Interference‐enhanced Raman scattering in SiO2/Si structures related to reflectance
Authors: Vančo Ľubomír , Kotlár Mário , Kadlečíková Magdaléna , Vretenár Viliam , Vojs Marian , Kováč Jaroslav 
Published: August 2019

AbstractEnhancement of Raman scattering due to optical interference may act as a source of error in the issues necessitating a determination of Raman intensity. Its dependence on thin film thickness is the conventional way how to examine the effects of optical interference in Raman signal. To provide a new platform for evaluation of signal coming from substrate in the presence of a transparent capping, we investigate its relation to reflectance (R) instead of the capping thickness. We derived a theoretical model, which was experimentally tested on simple structures consisting of SiO2 deposited on mono‐Si substrates. In agreement between the model and the experiment, interference enhancement is proportional to the product of (1 − R) terms taken at excitation and scattered light wavenumbers. We experimented with two different Raman bands in Si on two different Raman systems. The model was valid regardless of excitation, Raman band, and grating. Constructed for normal incidence, it was in agreement with experiment using objectives with numerical apertures up to 0.25 (0.32). The model was valid also in ultraviolet region, where imaginary part in refractive index of Si considerably rises.
The protective role of DMBT1 in cervical squamous cell carcinoma
Authors: Zhang Chun‐Xiao 
Published: August 2019

AbstractTo explore the possible influence of deleted in malignant brain tumor 1 (DMBT1) in cervical squamous cell carcinoma (CSCC). DMBT1 expression was detected by Real‐time reverse transcription PCR (qRT‐PCR) and immunohistochemistry in CSCC and adjacent normal tissues from 167 CSCC patients, and its relationship with clinicopathological features and prognosis was analyzed. Besides, the in vitro experiments, including MTT, Cell‐Light EdU, Wound‐healing, Transwell invasion, Annexin V‐FITC/PI staining, qRT‐PCR, and Western blot, were performed in SiHa and CaSKi cells, which were both divided into Blank, Vector, and DMBT1 groups. The mRNA level and the positive expression rate of DMBT1 in CSCC tissues were lower than the adjacent normal tissues. Moreover, DMBT1 positive rate was linked to FIGO stage, tumor diameter, lymph node metastasis, and tumor differentiation of CSCC. Besides, patients with positive DMBT1 expression had higher 5‐year survival rate than those negative ones. According to the in vitro experiments, SiHa and CaSKi cells with overexpressed DMBT1 showed the inhibition of proliferative ability and the enhancement of apoptosis with the upregulated pro‐apoptosis proteins (Bax and Cleaved caspase‐3) and down‐regulated anti‐apoptosis protein Bcl‐2. Moreover, compared with Blank group, DMBT1 group presented decrease in the migration and invasion of SiHa and CaSKi cells with the down‐expression of interstitial markers (N‐cadherin and Vimentin) and the up‐expression of epithelial marker E‐cadherin. DMBT1 was decreased in CSCC, whereas its overexpression can not only inhibit the proliferation, migration, and invasion, but induce the apoptosis of human CSCC cells, being a novel strategy for CSCC treatment.
Electroactive High‐Temperature Shape Memory Polymers with High Recovery Stress Induced by Ground Carbon Fibers
Authors: Li Xiaofeng , Wang Liancai , Zhang Ziyan , Kong Deyan , Ao Xinling , Xiao Xinli 
Published: August 2019

AbstractElectroactive shape memory polymers (SMPs) are suitable for remote controllable actuators or applications where direct heat is inconvenient, and herein an electroactive shape memory polyimide (EASMPI) is reported for the first time. EASMPI is synthesized by incorporating ground carbon fibers (GCFs) into a polyimide matrix to form a compact conductive network, and percolation threshold of 0.312 S m−1meets the demands of both electroactive and shape memory effects. The glass transition temperature of 302 °C for EASMPI is much higher than that of other electroactive SMPs, and its shape recovery is activated effectively by a voltage of 15.87 V. Recovery stress is crucial for shape memory materials to output work, and EASMPI produces high recovery stress of 40.1 MPa. The possible mechanisms are discussed, and GCF mainly accounts for its electroactivity and recovery stress. EASMPI shows vast potential in practical applications with its electroactive shape memory effect and high recovery stress at high temperature.
Preserved expressive language as a phenotypic determinant of Mosaic Angelman Syndrome
Authors: Carson Robert P. , Bird Lynne , Childers Anna K. , Wheeler Ferrin , Duis Jessica 
Published: August 2019

AbstractBackgroundAngelman Syndrome (AS) is a neurodevelopmental disorder with core features of intellectual disability, speech impairment, movement disorders, and a unique behavioral profile. Typically, AS results from absent maternal expression of UBE3A, but some individuals have imprinting defects in a portion of their cells. These individuals are mosaic for normal and defective UBE3A expression, resulting in mosaic AS (mAS) with a partial loss of gene expression.MethodsThis study aims to contrast the mAS phenotype to that of AS. Clinical characteristics of mAS were obtained from a parental survey of 22 mAS patients and from the Angelman Natural History study. These were contrasted with those of AS using historical data.ResultsDevelopmental delay was present in nearly all mAS patients, whereas the core features of AS were reported in less than 40%. While language and ability to manage activities of daily living were markedly improved over that expected in AS, mAS patients demonstrated a high incidence of behavioral challenges.ConclusionClinical work‐up of an individual with developmental delay, hyperactivity, anxiety, and an uncharacteristically happy demeanor should prompt methylation studies to rule out mAS. We expand the phenotypic spectrum of AS to include features that overlap with Prader‐Willi such as hyperphagia.
Generation and transmission of fractional‐order optical bright solitons in single mode fiber
Authors: Mehboob Abu B. , Usman Muhammad , Hussain Ashiq 
Published: August 2019

AbstractThis article addresses the generation and transmission of fractional‐order optical bright solitons (OBSs) in silica based single mode fiber. We take into account second‐order dispersion effect in the presence of anomalous dispersion and self‐phase modulation together with third‐order dispersion. Fractional‐order OBS have been extracted using nonlinear Schrodinger equation. We consider dispersion dominant case with variation of data rates from 10 to 60 Gbps covering ultralong distance of 9040 km. The transmission link is composed of optical amplifier with gain of 20 dB and a noise figure of 4 dB. The analytical computations are carried out to calculate the nonlinear dispersive effects and a comparison is made between the analytical and simulated results. Erbium‐doped fiber amplifier and dispersion compensated fiber have been used to overcome fluctuations and to maintain the fractional‐order OBS pulse profile. In the end, the outcomes are probed and compared on the basis of Q‐factor and bit error rate (BER). It is observed that best OBS transmission result is achieved at 40 Gbps, where Q‐factor is 9.85 with a corresponding BER of 2.91e−23.
A compact CPW‐fed UWB antenna with quadruple rejected bands
Authors: Zhong Zeng‐Pei , Liang Jia‐Jun , Fan Mo‐Lin , Huang Guan‐Long , He Wei , Chen Xiao‐Chen , Yuan Tao 
Published: August 2019

AbstractA compact coplanar‐waveguide (CPW)‐fed ultrawideband (UWB) antenna with quadruple rejected bands is proposed. To realize the bandwidth requirement of UWB communication, a gradient folk‐shaped radiating patch and a symmetrical ground plane are employed, which help to cover a frequency band from 2.7 to 10.7 GHz. In order to obtain four rejected bands within the UWB frequency band, four different slots including a cap‐shaped slot, two meandering slots, and a split‐ring are utilized, which contribute to generate rejected bands at C‐band (3.60‐4.32 GHz), wireless local area networks bands (5.17‐5.32 GHz and 5.80‐5.93 GHz), and International Telecommunication Union service band (7.8‐8.2 GHz), respectively. Excellent band‐notched features are obtained by optimizing the positions and lengths of the four slots. Simulated and measured results show that the proposed antenna is especially suitable for UWB communication.