bluuebunny/crossref_metadata_2025_split huggingface dataset:
Promotion of attendance for mammographie screening through general practice: a randomised trial of two strategies
Authors: Clover Kerrie A , Redman Selina , Sanson‐Fisher Robert W , Forbes John F , Dickinson James A 
Published: September 2019

ObjectiveTo compare the effectiveness of two strategies — patient education and practitioner recommendation — in encouraging women to attend for mammographic screening.DesignThe study was a prospective randomised controlled trial. Women aged between 40 and 70 years attending a general practitioner participated in the study. Consenting, eligible women were randomly allocated to one of the two strategy groups.SettingThe study was conducted in private general practice in Newcastle, New South Wales.ParticipantsThe general practitioners who took part in the study were a non‐random sample of practitioners: 20 were approached, two declined to participate, and five failed to begin recruitment, leaving 13 practitioners who took part in the study. A total of 302 women aged 40‐69 were recorded as attending the surgeries during recruitment sessions. Twenty women did not consent to the study and 73 were ineligible. Thirty‐four women were not given the intervention because the general practitioner forgot or did not have time. There were 92 women in the simple recommendation group and 83 women in the patient education group.InterventionsAn intensive patient education approach based on health belief principles was compared with a simple recommendation by the general practitioner that the woman have a mammogram.Main outcome measureAttendance rates were calculated from screening service attendance records.ResultsNo significant difference in attendance rates was observed between the two groups, 82% of the simple recommendation group and 91 % of the patient education group attended for screening.ConclusionsThese results suggest that mammographic screening can be effectively promoted in general practice without extensive patient education.
Emergency transport of critically ill children: stabilisation before departure
Authors: Henning Robert 
Published: September 2019

ObjectiveTo provide up‐to‐date practical information, relevant to Australian conditions and practice, on stabilising the condition of critically ill children who need transport to a paediatric hospital.Data sources and selectionInformation on current resuscitation practice was sought from relevant original articles and reviews in the recent medical literature, from textbooks and monographs published in the last 10 years.Data synthesis and conclusionsA recent study found that 47% of 100 children who needed emergency interhospital transfer experienced problems which should have been preventable by greater availability to referring doctors of information on pretransport stabilisation of critically ill children. Hypoventilation, hypoxaemia and hypotension are commonly found in critically ill children before transport, as are difficulties with endotracheal tube care, sedation and analgesia. Mild physiological disturbances are likely to become severe and life‐ threatening during transfer unless they are corrected before departure. Early discussion of the child's problems and the transfer plan with senior staff at the nearest paediatric Intensive care unit may be helpful in planning the pre‐transfer resuscitation.
Multiantigenic Nanoformulations Activate Anticancer Immunity Depending on Size
Authors: Li Shengxian , Feng Xiangru , Wang Jixue , Xu Weiguo , Islam Mohammad Ariful , Sun Tianmeng , Xie Zhigang , Wang Chunxi , Ding Jianxun , Chen Xuesi 
Published: September 2019

AbstractNanoparticle‐adjuvanted cancer vaccines are attracting increasing attention because they can induce an effective anticancer immune response. Single‐antigen vaccines are inefficient to inhibit cancer progression due to the heterogeneity of tumors and the antigenicity alteration of tumor‐associated antigens. Therefore, the efficient delivery of multiple antigens to antigen‐presenting cells is an excellent opportunity for strong anticancer immunity. In this study, three immunoadjuvant‐loaded multiantigenic nanoparticles MANPs/R837 with different diameters, i.e., 83, 103, and 122 nm, are prepared through coating of the cancer cell membrane as a source of multiple antigens onto the imiquimod R837‐loaded poly(lactic‐co‐glycolic acid) nanoparticles. The MANP/R837 with a diameter of 83 nm (MANP83/R837) shows the most efficient delivery of the payload to the draining lymph nodes and achieves the best antigen presentation to T lymphocytes. Compared with the other two nanovaccines, MANP83/R837 has a stronger inhibitory effect on tumor growth and metastasis. In the combination therapy with checkpoint blockade therapy using programmed cell death‐1 antibody, MANPs/R837 show effective inhibition against tumor progression, and MANP83/R837 achieves the most exciting effect. Therefore, MANPs/R837, as a promising therapeutic cancer vaccine, demonstrates great prospects in cancer immunotherapy.
Decoy Oligodeoxynucleotides, Polysaccharides, and Targeted Peptide‐Functionalized Gold Nanorods for the Combined Treatment of Rheumatoid Arthritis
Authors: Zhang Nan , Zhang Shasha , Xu Chunyu , Fu Lingling , Liu Tuanbing , Zhao Yongxing 
Published: September 2019

Adv. Healthcare Mater. 2018, 7, 1800982The above article, published online on 04 November 2018 in Wiley Online Library (https://wileyonlinelibrary.com), has been retracted by agreement between the authors, the journal Editor‐in‐Chief, and Wiley‐VCH Verlag GmbH & Co. KGaA, Weinheim. The retraction has been agreed due to errors in data presentation and non‐reproducibility of the results.N. Zhang, S. S. Zhang, C. Y. Xu, L. L. Fu, T. B. Liu, Y. X. Zhao, Adv. Healthcare Mater. 2018, 7, 1800982, DOI:10.1002/adhm.201800982.
An Atom‐Economical Approach to 2‐Triazolyl Thio‐/Seleno Pyridines via Ruthenium‐Catalyzed One‐pot [3+2]/[2+2+2] Cycloadditions
Authors: Bhatt Divya , Singh Prasoon Raj , Kalaramna Pratibha , Kumar Krishn , Goswami Avijit 
Published: September 2019

AbstractAn efficient method to access 2‐triazolyl thio‐/selenopyridines with good to excellent yields by ruthenium(II)‐catalyzed one‐pot [3+2]/[2+2+2] cycloaddition reactions of azides, 1‐alkynyl thio‐/selenocyanates and 1,6‐diynes is reported. This atom‐economical catalytic strategy offers a mild and practical approach to access a variety of such cycloadducts with good to excellect regioselectivities. The protocol was further extended to the synthesis of 3,3′‐bis(triazolyl thio‐/seleno)‐2,2′‐bipyridines by the reaction of tetraynes with 1‐alkynyl thio‐/selenocyanates in the presence of aryl/alkyl azides.magnified image
Highly Stable, Solution‐Processed Ga‐Doped IZTO Thin Film Transistor by Ar/O2 Plasma Treatment
Authors: Mude Narendra Naik , Bukke Ravindra Naik , Saha Jewel Kumer , Avis Christophe , Jang Jin 
Published: September 2019

AbstractThe effects of gallium doping into indium–zinc–tin oxide (IZTO) thin film transistors (TFTs) and Ar/O2 plasma treatment on the performance of a‐IZTO TFT are reported. The Ga doping ratio is varied from 0 to 20%, and it is found that 10% gallium doping in a‐IZTO TFT results in a saturation mobility (µsat) of 11.80 cm2 V−1 s−1, a threshold voltage (Vth) of 0.17 V, subthreshold swing (SS) of 94 mV dec−1, and on/off current ratio (Ion/Ioff) of 1.21 × 107. Additionally, the performance of 10% Ga‐doped IZTO TFT can be further improved by Ar/O2 plasma treatment. It is found that 30 s plasma treatment gives the best TFT performances such as µsat of 30.60 cm2 V−1 s−1, Vth of 0.12 V, SS of 92 mV dec−1, and Ion/Ioff ratio of 7.90 × 107. The bias‐stability of 10% Ga‐doped IZTO TFT is also improved by 30 s plasma treatment. The enhancement of the TFT performance appears to be due to the reduction in the oxygen vacancy and OH concentrations.
Recent Advances in Preparation and Applications of Magnetic Framework Composites
Authors: Ma Yao Jia , Jiang Xiao Xue , Lv Yun Kai 
Published: September 2019

AbstractMetal‐organic frameworks (MOFs) offer ample characteristics, such as easy synthesis, high surface area, tunable porosities, open metal sites, post‐synthesis modification, making them attractive for diverse applications. Since magnetic particles can be positioned and separated by a magnetic field, magnetic framework composites (MFCs) have attracted tremendous attention. In this review, different methods of preparing MFCs, including direct mixing, in‐situ growth of magnetic particles, embedding method, layer‐by‐layer growth method and encapsulation method, will be discussed in detail. Moreover, their applications in catalysis, adsorption, biomedicine and sensing will also be introduced.
Highly Dispersed and Small‐Sized Nickel(II) Hydroxide Co‐Catalyst Prepared by Photodeposition for Hydrogen Production
Authors: Zhang Feiyan , Dong Yuming , Jiang Pingping , Wang Guangli , Zhao Na , Zhang Huizhen , Li Dandan , Lyu Jinze , Wang Yan , Li Ji , Zhu Yongfa 
Published: September 2019

AbstractPhotodeposition has been widely used as a mild and efficient synthetic method to deposit co‐catalysts. It is also worth studying how to synthesize non‐noble metal photocatalysts with uniform dispersion. Different synthetic conditions in photodeposition have a certain influence on particle size distribution and photocatalytic activity. Therefore, we designed experiments to prepare the inexpensive composite photocatalyst Ni(OH)2/g‐C3N4 by photodeposition. The Ni(OH)2 co‐catalysts disperse uniformly with particle sizes of about 10 nm. The photocatalytic hydrogen production rate of Ni(OH)2/g‐C3N4 reached about 19 mmol g−1 h−1, with the Ni(OH)2 deposition amount about 1.57 %. During 16 h stability testing, the rate of hydrogen production did not decrease significantly. The composite catalyst also revealed a good hydrogen production performance under sunlight. The Ni(OH)2 co‐catalyst enhanced the separation ability of photogenerated carriers, which was proved by surface photovoltage and fluorescence analysis.
Bridges to Stability: Engineering Disulfide Bonds Towards Enhanced Lipase Biodiesel Synthesis
Authors: Gihaz Shalev , Bash Yael , Rush Inbal , Shahar Anat , Pazy Yael , Fishman Ayelet 
Published: September 2019

AbstractComputational design of disulfide bonds was performed for lipase from Geobacillus stearothermophilus T6 (LipT6) for enhanced methanol stability and improved biodiesel production. Thirteen double mutants comprising new cysteine pairs were screened and evaluated for their stability in 70 % methanol. Superior stability was found with variant E251C/G332C (M13) having a 5.5‐fold higher hydrolysis activity and enhanced unfolding temperature (Tm) of +7.9 °C in methanol compared with wild‐type. Moreover, M13 converted nearly 80 % waste chicken oil to biodiesel, representing a 2.4‐fold improvement relative to the WT. Structural studies using X‐ray crystallography confirmed the existence of the engineered disulfide bonds shedding light on the link between the bond location and backbone architecture with its stabilization impact. Rational integration of disulfide bonds is suggested to be a feasible method to promote elevated stability in organic solvents for various industrial applications such as biodiesel synthesis.
Changing Body Weight–Based Dosing to a Flat Dose for Avelumab in Metastatic Merkel Cell and Advanced Urothelial Carcinoma
Authors: Novakovic Ana M. , Wilkins Justin J. , Dai Haiqing , Wade Janet R. , Neuteboom Berend , Brar Satjit , Bello Carlo L. , Girard Pascal , Khandelwal Akash 
Published: September 2019

Avelumab, an anti–programmed death‐ligand 1 monoclonal antibody approved for the treatment of metastatic Merkel cell carcinoma and platinum‐treated urothelial carcinoma, was initially approved with a 10 mg/kg weight‐based dose. We report pharmacokinetic (PK)/pharmacodynamic analyses for avelumab comparing weight‐based dosing and a flat 800 mg dose, developed using data from 1,827 patients enrolled in 3 clinical trials (NCT01772004, NCT01943461, and NCT02155647). PK metrics were simulated for weight‐based and flat‐dosing regimens and summarized by quartiles of weight. Derived exposure metrics were used in simulations of exposure‐safety (various tumors) and exposure‐efficacy (objective responses; Merkel cell or urothelial carcinoma). Flat dosing was predicted to provide similar exposure to weight‐based dosing, with slightly lower variability. Exposure‐safety and exposure‐efficacy simulations suggested similar benefit:risk profiles for the two dosing regimens. These pharmacometric analyses provided the basis for the US Food and Drug Administration approval of a flat dose of avelumab 800 mg every 2 weeks in approved indications.
Pore Surface Engineering of Covalent Triazine Frameworks@MoS2 Electrocatalyst for the Hydrogen Evolution Reaction
Authors: Qiao Shanlin , Zhang Boying , Li Qing , Li Zheng , Wang Wenbo , Zhao Jia , Zhang Xiangjing , Hu Yongqi 
Published: September 2019

AbstractElectrochemical water splitting is an important strategy for the mass production of hydrogen. Development of synthesizable catalysts has always been one of the biggest obstacles to replace platinum‐group catalysts. In this work, a high quality crystal polymer covalent triazine framework [CTF; Brunauer–Emmett–Teller (BET) surface area of 1562.6 m2 g−1] is synthesized and MoS2 nanoparticles are grown in situ into/onto the 1 D channel arrays or the external surface for electrocatalysis [hydrogen evolution reaction (HER)] . The state‐of‐the‐art CTFs@MoS2 structure exhibits superior catalytic kinetics with an overpotential of 93 mV and Tafel slope of 43 mV dec−1, which is improved over most other reported analogous catalysts. The inherent π‐conjugated crystal channels in CTFs provides a multifunctional support for electron transmission and mass diffusion during the hydrogen evolution process. Catalytic kinetics analysis shows that the HER performance is closely correlated to the hierarchical pore parameters and aggregated thickness of MoS2 nanoparticles. This work provides an attractive and durable alternative to synthesize high activity and stable catalysts for HER.
Simulating a Spill of Diluted Bitumen: Environmental Weathering and Submergence in a Model Freshwater System
Authors: Stoyanovich Sawyer S. , Yang Zeyu , Hanson Mark , Hollebone Bruce P. , Orihel Diane M. , Palace Vince , Rodriguez-Gil Jose L. , Faragher Robert , Mirnaghi Fatemah S. , Shah Keval , Blais Jules M. 
Published: September 2019

Abstract
The main petroleum product transported through pipelines in Canada is diluted bitumen (dilbit), a semiliquid form of heavy crude oil mixed with natural gas condensates to facilitate transport. The weathering, fate, behavior, and environmental effects of dilbit are crucial to consider when responding to a spill; however, few environmental studies on dilbit have been completed. We report on 11-d-long experimental spills of dilbit (Cold Lake Winter Blend) in outdoor microcosms meant to simulate a low-energy aquatic system containing natural lake water and sediments treated with low (1:8000 oil:water) and high (1:800 oil:water) volumes of dilbit. In the first 24 h of the experiment, volatile hydrocarbons quickly evaporated from the dilbit, resulting in increased dilbit density and viscosity. These changes in dilbit's physical and chemical properties ultimately led to its submergence after 8 d. We also detected rapid accumulation of polycyclic aromatic compounds in the water column of the treated microcosms following the spills. The present study provides new information on the environmental fate and behavior of dilbit in a freshwater environment that will be critical to environmental risk assessments of proposed pipeline projects. In particular, the study demonstrates the propensity for dilbit to sink under ambient environmental conditions in freshwaters typical of many boreal lakes. Environ Toxicol Chem 2019;38:2621–2628. © 2019 SETAC
Diet Associations With Nonalcoholic Fatty Liver Disease in an Ethnically Diverse Population: The Multiethnic Cohort
Authors: Noureddin Mazen , Zelber‐Sagi Shira , Wilkens Lynne R. , Porcel Jacqueline , Boushey Carol J. , Le Marchand Loïc , Rosen Hugo R. , Setiawan Veronica Wendy 
Published: September 2019

Background and Aims
Epidemiological data on dietary risk factors for nonalcoholic fatty liver disease (NAFLD) from population‐based studies, particularly in an ethnically diverse population, are scarce. We examined dietary factors in relation to NAFLD risk in African Americans, Japanese Americans, Latinos, native Hawaiians, and whites in the Multiethnic Cohort (MEC).

Approach and Results
A nested case–control analysis was conducted within the MEC, a large prospective study with >215,000 older adult participants in Hawaii and California. NAFLD was identified using Medicare claims data, and controls were selected among participants without liver disease and individually matched to cases by birth year, sex, ethnicity, and length of Medicare enrollment. Diet was assessed at baseline through a validated quantitative food frequency questionnaire. Diet–NAFLD associations were quantified by odds ratios and 95% confidence intervals using multivariable conditional logistic regression. The study consisted of 2,974 NAFLD cases (518 with cirrhosis, 2,456 without cirrhosis) and 29,474 matched controls. Red meat (P trend = 0.010), processed red meat (P trend = 0.004), poultry (P trend = 0.005), and cholesterol (P trend = 0.005) intakes were positively associated with NAFLD, while dietary fiber intake (P trend = 0.003) was inversely associated with risk. Stronger associations were observed between red meat and cholesterol and NAFLD with cirrhosis than without cirrhosis (P heterogeneity ≤0.014).

Conclusions
Dietary factors are independently associated with NAFLD and NAFLD‐related cirrhosis in a multiethnic population. Decreasing the consumption of cholesterol, red and processed meat, and poultry and increasing consumption of fiber may reduce the risk for NAFLD and related advanced liver disease.
Changes in Protein Glycosylation as a Result of Aptamer Interactions with Cancer Cells
Authors: Drabik Anna , Ner‐Kluza Joanna , Hartman Kinga , Mayer Günter , Silberring Jerzy 
Published: September 2019

PurposeBased on the recent aptamer‐related breast cancer studies, which indicate the therapeutic role of specific oligonucleotide sequences, experiments have been designed in an attempt to unravel the molecular targets of this mechanism. This article describes the study on glycoproteome changes in breast cancer cells as a result of their interactions with aptamers.Experimental designAberrations in protein glycosylation play an important role in tumorigenesis and influence cancer progression, metastasis, immunoresponse, and chemoresistance, therefore this study is focused on the identification of the alterations in glycan expression on the surface of proteins as a potential and innovative tool for biomedical applications of aptamers in cancer treatment.ResultsTwo proteins, kinesin‐like protein (KI13B) and proliferating cell nuclear antigen (PCNA), have been identified that carry N‐glycan epitopes after conjugation with aptamer sequences.Conclusions and clinical relevanceMultiple features of aptamers as an alternative to protein antibodies are utilized for various biomedical applications ranging from biomarker discovery, bioimaging, targeted therapy, drug delivery, and drug pharmacokinetics and biodistribution. Frequently, aptamers bind to their target molecules and modulate their function. Such therapeutic aptamers can modify the biological pathways for treatment of many types of diseases, such as cancer.
Blue Strobe Pyrotechnic Composition Based on Aminoguanidinium Nitrate
Authors: Juknelevicius Dominykas , Klapötke Thomas M. , Ramanavicius Arunas 
Published: September 2019

AbstractA new blue strobe pyrotechnic composition based on aminoguanidinium nitrate (AGN) is described. Alternative compositions from the literature that contain either tetramethylammonium nitrate or guanidinium nitrate are compared to the new AGN composition. Pyrotechnic compositions were processed into 13 mm pellets and 5 mm rods. Strobe frequency, linear burning rate, chromaticity coordinates and color purity (of the flash reaction), sensitivity to mechanical stimulii, DTA curves, humidity tests, high speed camera footage are reported and discussed. Finally a discussion of the strobe reaction mechanism has been included.
Design, Synthesis and Pharmacological Evaluation of 4‐Hydroxycoumarin Derivatives as Antiproliferative Agents.
Authors: Pilli Govindaiah , Dumala Naresh , Sreeja Jamuna S. , John Rince , Sengupta Suparna , Grover Paramjit , Prakash M. Jaya 
Published: September 2019

AbstractA series of novel 4‐hydroxycoumarin based acryloylcyanohydrazone derivatives were synthesized and evaluated for in vitro antiproliferative activity against different cancer cell lines (A‐549, HeLa, SK−N‐SH, and MCF‐7) by MTT assay method. All the test compounds (8 a‐m) were exhibited excellent antiproliferative activity (IC50 values ranging between 8.20 to 27.39 μM) against all the tested cancer cell lines. Pharmacological studies like cell cycle progression arrest and tubulin polymerisation inhibition studies were performed for the most potent compound 8 j. Further these studies were confirmed that the compound 8 j induced the cell cycle arrest at G2/M phase and tubulin polymerisation was inhibited with IC50=11.03 μM. Molecular docking simulation for the compound 8 j also revealed that, it has strong binding interactions towards tubulin protein. This in silico target validation suggested the tubulin is the target for the designed potent compound 8 j.
Palladium Nanoparticles Immobilized on Schiff Base‐Functionalized Graphene‐Oxide: Application in Carbon‐Carbon Cross‐Coupling Reactions
Authors: Parmanand  , Kumari Shweta , Mittal Ayushi , Kumar Anoop , Krishna  , Sharma Sunil K. 
Published: September 2019

AbstractPalladium nanoparticles immobilized on Schiff base‐functionalized graphene‐oxide (GO−Pd) has been synthesized and characterized by FT‐IR, Raman, PXRD, UV‐Visible, TGA, XPS, FE‐SEM, TEM, EDAX, Elemental mapping, BET, AAS and ICP MS analysis. The GO−Pd showed promising catalytic activity for the Suzuki‐Miyaura, Hiyama and Heck‐Mizoroki coupling reactions with higher yields (up to 95%). GO−Pd can be easily filtered out from the reaction mixture and reused up to six times without significant loss of catalytic activity. All of the synthetic products obtained were fully characterized from their spectral data.
Application of Response Surface Methodology for the Optimization of Drying Parameters of ZSM‐5 Extruded Catalysts
Authors: Tian Chao , Wu Dongfang 
Published: September 2019

AbstractA fundamental step in the fabrication of industrial catalysts is to conduct mechanical properties assessment. In this paper, the mathematical models were adequately developed to optimize the mechanical properties of ZSM‐5 extruded catalysts using response surface methodology. And central composite orthogonal design with three parameters viz. drying temperature, drying time, and moisture content was utilized to investigate the effects of drying parameters on the mechanical strength and Weibull modulus. Statistics showed that the responses varied regularly with the development of experiments. And a material with optimal mechanical properties would possess both higher mechanical strength and Weibull modulus. Furthermore, it was found that drying process significantly impacts the morphology of the extruded catalysts, rather than the pore structure through the analysis of scanning electron microscopy (SEM) and Brunauer‐Emmett‐Teller (BET). Thus, we concluded that the reduction in surface crack size is the main reason of the improvement of mechanical properties.