bluuebunny/crossref_metadata_2025_split huggingface dataset:
Levodopa Effect and Motor Function in Late Stage Parkinson’s Disease
Authors: Rosqvist Kristina , Horne Malcolm , Hagell Peter , Iwarsson Susanne , Nilsson Maria H. , Odin Per 
Published: February 2018

Background: It is unclear to which degree Levodopa (L-dopa) remains effective also in the late stage of Parkinson’s disease (PD) and to which degree motor fluctuations and dyskinesias remain a problem. Objective: To assess responsiveness of motor symptomatology to L-dopa in a group of patients with late stage PD. Moreover, to investigate the extent to which motor fluctuations and dyskinesias occur. Methods: Thirty PD patients in Hoehn and Yahr (HY) stages IV and V in “on” were included. L-dopa responsiveness was assessed with a standardized L-dopa test in the defined “off” and defined “on” states. Motor function was assessed by the Unified PD Rating Scale (UPDRS) III and timed tests. Motor fluctuations and dyskinesias were assessed by the UPDRS IV. The participants were further monitored for 10 days with a mobile movement-analyses-system, the Parkinson’s Kinetigraph (PKG). The median (q1–q3) L-dopa equivalent daily dose (LEDD) was 799 (536–973) mg. Results: The UPDRS III score improved with ≥15% in 15 (50%) and with ≥30% in six (20%) participants during the L-dopa test. The median (q1–q3) UPDRS III score in “off” was 46 (37–53) and in “on” 36 (28–46). Twenty-one (70%) of the participants reported either predictable or unpredictable “off” fluctuations (items 36–37). The prevalence of dyskinesias (item 32, duration of dyskinesias ≥1) was 47%. The PKG indicated that dyskinesias primarily were mild and that a majority had a pronounced “off” symptomatology, spending a large proportion of the day either asleep or very inactive. Conclusions: Half of a group of patients with late stage PD had an L-dopa response of ≥15% on the UPDRS III. According to the UPDRS IV, a majority of the patients had motor fluctuations and about half had dyskinesias, although the PKG results suggested that these were not very severe.
Monoaminergic Markers Across the Cognitive Spectrum of Lewy Body Disease
Authors: van der Zee Sygrid , Vermeiren Yannick , Fransen Erik , Van Dam Debby , Aerts Tony , Gerritsen Marleen J. , Spikman Jacoba M. , van Laar Teus , De Deyn Peter P. 
Published: February 2018

Background: Lewy body disorders, including Parkinson’s disease (PD), Parkinson’s disease dementia (PDD) and dementia with Lewy bodies (DLB), are characterized by profound central and peripheral monoaminergic dysfunction. Objective: To investigate whether these alterations depend on dementia status, we measured cerebrospinal fluid (CSF) and serum monoamine and metabolite levels across subgroups of the cognitive spectrum, and evaluated their marker potential afterwards. Methods: In total, 153 subjects were included, of which 43 healthy controls (HC), 28 PD patients with normal cognition (PD-NC), 26 patients with PD and mild cognitive impairment (PD-MCI), 18 PDD patients, and 38 DLB patients. The levels of monoamines and metabolites in paired CSF and serum samples were analyzed applying reversed-phase high-performance liquid chromatography with electrochemical detection. Results: Firstly, when comparing subgroups, CSF 3-methoxy-4-hydroxyphenylglycol (MHPG) levels were found lowest in HC and PD-NC groups and significantly higher in PDD/DLB patients. In addition, CSF 5-hydroxyindoleacetic acid (5-HIAA) levels differed significantly between HC and PD-MCI/PDD, and DLB patients ( P≤0.001), but not between HC and PD-NC patients. Secondly, when performing logistic regression, it was shown that particularly CSF/serum MHPG levels and the serum MHPG to noradrenaline (NA) ratio effectively differentiated between HC and (non-)pooled PD subgroups (AUC = 0.914–0.956), and PDD and DLB patients (AUC = 0.822), respectively. Furthermore, CSF 5-HIAA was the most discriminative parameter to differentiate between PD-NC and PD-MCI (AUC = 0.808), and, PD-NC and PDD subgroups (AUC = 0.916). Conclusions: Our data revealed that especially alterations of the noradrenergic neurotransmitter system could distinguish between Lewy body disorder subtypes, pinpointing CSF/serum MHPG and NA as potential stage markers across the cognitive spectrum.
Effectiveness of a Goal-Based Intensive Rehabilitation in Parkinsonian Patients in Advanced Stages of Disease
Authors: Ortelli Paola , Ferrazzoli Davide , Bera Rossana , Caremani Luca , Giladi Nir , Maestri Roberto , Frazzitta Giuseppe 
Published: February 2018

Background: Parkinsonian patients in advanced stages of disease suffer from many motor and non-motor symptoms, whose responsiveness to dopamine replacement therapy and deep brain stimulation is poor. It is necessary to find complementary strategies in order to improve the clinical conditions of patients in advanced Parkinson’s disease (PD) stages. Objective: We aimed to understand whether an inpatient, motor-cognitive, multidisciplinary, aerobic, intensive and goal-based rehabilitation treatment (MIRT), specifically designed for PD, is effective for patients in advanced stages of disease. Methods: 638 Parkinsonian patients, hospitalized to undergo a 4-week MIRT, were retrospectively identified. According to the Hoehn & Yahr (H&Y) scale, 496 were in H&Y stage 3 and 142 in H&Y stage 4-5. Outcome measures included: Unified Parkinson’s Disease Rating Scale (UPDRS), Berg Balance Scale (BBS), Timed Up and Go Test (TUG), Six Minute Walk Test (6MWT), and Parkinson’s Disease Disability Scale (PDDS). Results: At baseline all measures, except UPDRS IV, significantly worsened passing from H&Y stage 3 to H&Y stage 4-5 ( p≤0.002 all). After rehabilitation all outcome measures significantly improved in both groups of patients ( p < 0.0001 all). Comparing the amount of improvement in the two groups, significant differences were observed only for the changes in BBS and TUG (both p < 0.0001 after adjustment), with a better improvement in the H&Y stage 4-5 group. Conclusions: A multidisciplinary, motor-cognitive, intensive and goal-based rehabilitation treatment, such as MIRT, could be an effective complementary treatment in PD patients in advanced stages of disease.
HAZMAT. III. The UV Evolution of Mid- to Late-M Stars with GALEX
Authors: Schneider Adam C. , Shkolnik Evgenya L. 
Published: February 2018

Abstract
Low-mass stars are currently the most promising targets for detecting and characterizing habitable planets in the solar neighborhood. However, the ultraviolet (UV) radiation emitted by such stars can erode and modify planetary atmospheres over time, drastically affecting their habitability. Thus, knowledge of the UV evolution of low-mass stars is critical for interpreting the evolutionary history of any orbiting planets. Shkolnik & Barman used photometry from the Galaxy Evolution Explorer (GALEX) to show how UV emission evolves for early-type M stars (>0.35 M
⊙). In this paper, we extend their work to include both a larger sample of low-mass stars with known ages as well as M stars with lower masses. We find clear evidence that mid- and late-type M stars (0.08–0.35 M
⊙) do not follow the same UV evolutionary trend as early-Ms. Lower-mass M stars retain high levels of UV activity up to field ages, with only a factor of 4 decrease on average in GALEX NUV and FUV flux density between young (<50 Myr) and old (∼5 Gyr) stars, compared to a factor of 11 and 31 for early-Ms in NUV and FUV, respectively. We also find that the FUV/NUV flux density ratio, which can affect the photochemistry of important planetary biosignatures, is mass- and age-dependent for early-Ms, but remains relatively constant for the mid- and late-type Ms in our sample.
The Odd Isotope Fractions of Barium in the Strongly r-process-enhanced (r-II) Stars*
Authors: Wenyuan Cui , Xiaohua Jiang , Jianrong Shi , Gang Zhao , Bo Zhang 
Published: February 2018

Abstract
We determined the f
odd,Ba values, 0.46 ± 0.08, 0.51 ± 0.09, 0.50 ± 0.13, and 0.48 ± 0.12, that correspond to the r-contribution 100% for four r-II stars, CS 29491-069, HE 1219-0312, HE 2327-5642, and HE 2252-4225, respectively. Our results suggest that almost all of the heavy elements (in the range from Ba to Pb) in r-II stars have a common origin, that is, from a single r-process (the main r-process). We found that the f
odd,Ba has an intrinsic nature, and should keep a constant value of about 0.46 in the main r-process yields, which is responsible for the heavy element enhancement of r-II stars and of our Galaxy chemical enhancement. In addition, except for the abundance ratio [Ba/Eu] the f
odd,Ba is also an important indicator, which can be used to study the relative contributions of the r- and s-processes during the chemical evolution history of the Milky Way and the enhancement mechanism in stars with peculiar abundances of heavy elements.
The Orbit of the Companion to HD 100453A: Binary-driven Spiral Arms in a Protoplanetary Disk
Authors: Wagner Kevin , Dong Ruobing , Sheehan Patrick , Apai Dániel , Kasper Markus , McClure Melissa , Morzinski Katie M. , Close Laird , Males Jared , Hinz Phil , Quanz Sascha P. , Fung Jeffrey 
Published: February 2018

Abstract
HD 100453AB is a 10 ± 2 Myr old binary whose protoplanetary disk was recently revealed to host a global two-armed spiral structure. Given the relatively small projected separation of the binary (1.″05, or ∼108 au), gravitational perturbations by the binary seemed to be a likely driving force behind the formation of the spiral arms. However, the orbit of these stars remained poorly understood, which prevented a proper treatment of the dynamical influence of the companion on the disk. We observed HD 100453AB between 2015 and 2017, utilizing extreme adaptive optics systems on the Very Large Telescope and the Magellan Clay Telescope. We combined the astrometry from these observations with published data to constrain the parameters of the binary’s orbit to a = 1.″06 ± 0.″09, e = 0.17±0.07, and i = 32.°5 ± 6.°5. We utilized publicly available ALMA 12CO data to constrain the inclination of the disk,

, which is relatively coplanar with the orbit of the companion and consistent with previous estimates from scattered light images. Finally, we input these constraints into hydrodynamic and radiative transfer simulations to model the structural evolution of the disk. We find that the spiral structure and truncation of the circumprimary disk in HD 100453 are consistent with a companion-driven origin. Furthermore, we find that the primary star’s rotation, its outer disk, and the companion exhibit roughly the same direction of angular momentum, and thus the system likely formed from the same parent body of material.
Multi-spacecraft Observations of the Rotation and Nonradial Motion of a CME Flux Rope Causing an Intense Geomagnetic Storm
Authors: Liu Yi A. , Liu Ying D. , Hu Huidong , Wang Rui , Zhao Xiaowei 
Published: February 2018

Abstract
We present an investigation of the rotation and nonradial motion of a coronal mass ejection (CME) from AR 12468 on 2015 December 16 using observations from SDO, SOHO, STEREO A, and Wind. The EUV and HMI observations of the source region show that the associated magnetic flux rope (MFR) axis pointed to the east before the eruption. We use a nonlinear force-free field (NLFFF) extrapolation to determine the configuration of the coronal magnetic field and calculate the magnetic energy density distributions at different heights. The distribution of the magnetic energy density shows a strong gradient toward the northeast. The propagation direction of the CME from a Graduated Cylindrical Shell (GCS) modeling deviates from the radial direction of the source region by about 45° in longitude and about 30° in latitude, which is consistent with the gradient of the magnetic energy distribution around the AR. The MFR axis determined by the GCS modeling points southward, which has rotated counterclockwise by about 95° compared with the orientation of the MFR in the low corona. The MFR reconstructed by a Grad–Shafranov (GS) method at 1 au has almost the same orientation as the MFR from the GCS modeling, which indicates that the MFR rotation occurred in the low corona. It is the rotation of the MFR that caused the intense geomagnetic storm with the minimum D
st of −155 nT. These results suggest that the coronal magnetic field surrounding the MFR plays a crucial role in the MFR rotation and propagation direction.
A Radio Frequency Study of the Accreting Millisecond X-ray Pulsar, IGR J16597–3704, in the Globular Cluster NGC 6256
Authors: Tetarenko A. J. , Bahramian A. , Wijnands R. , Heinke C. O. , Maccarone T. J. , Miller-Jones J. C. A. , Strader J. , Chomiuk L. , Degenaar N. , Sivakoff G. R. , Altamirano D. , Deller A. T. , Kennea J. A. , Li K. L. , Plotkin R. M. , Russell T. D. , Shaw A. W. 
Published: February 2018

Abstract
We present Karl G. Jansky Very Large Array radio frequency observations of the new accreting millisecond X-ray pulsar (AMXP), IGR J16597−3704, located in the globular cluster NGC 6256. With these data, we detect a radio counterpart to IGR J16597−3704, and determine an improved source position. Pairing our radio observations with quasi-simultaneous Swift/XRT X-ray observations, we place IGR J16597−3704 on the radio–X-ray luminosity plane, where we find that IGR J16597−3704 is one of the more radio-quiet neutron star low-mass X-ray binaries known to date. We discuss the mechanisms that may govern radio luminosity (and in turn jet production and evolution) in AMXPs. Furthermore, we use our derived radio position to search for a counterpart in archival Hubble Space Telescope and Chandra X-ray Observatory data, and estimate an upper limit on the X-ray luminosity of IGR J16597−3704 during quiescence.
Spectroscopic Observations of Current Sheet Formation and Evolution
Authors: Warren Harry P. , Brooks David H. , Ugarte-Urra Ignacio , Reep Jeffrey W. , Crump Nicholas A. , Doschek George A. 
Published: February 2018

Abstract
We report on the structure and evolution of a current sheet that formed in the wake of an eruptive X8.3 flare observed at the west limb of the Sun on 2017 September 10. Using observations from the EUV Imaging Spectrometer (EIS) on Hinode and the Atmospheric Imaging Assembly (AIA) on the Solar Dynamics Observatory, we find that plasma in the current sheet reaches temperatures of about 20 MK and that the range of temperatures is relatively narrow. The highest temperatures occur at the base of the current sheet, in the region near the top of the post-flare loop arcade. The broadest high temperature line profiles, in contrast, occur at the largest observed heights. Furthermore, line broadening is strong very early in the flare and diminishes over time. The current sheet can be observed in the AIA 211 and 171 channels, which have a considerable contribution from thermal bremsstrahlung at flare temperatures. Comparisons of the emission measure in these channels with other EIS wavelengths and AIA channels dominated by Fe line emission indicate a coronal composition and suggest that the current sheet is formed by the heating of plasma already in the corona. Taken together, these observations suggest that some flare heating occurs in the current sheet, while additional energy is released as newly reconnected field lines relax and become more dipolar.
A Slowly Precessing Disk in the Nucleus of M31 as the Feeding Mechanism for a Central Starburst
Authors: Lockhart K. E. , Lu J. R. , Peiris H. V. , Rich R. M. , Bouchez A. , Ghez A. M. 
Published: February 2018

Abstract
We present a kinematic study of the nuclear stellar disk in M31 at infrared wavelengths using high spatial resolution integral field spectroscopy. The spatial resolution achieved, FWHM = 0.″12 (0.45 pc at the distance of M31), has only previously been equaled in spectroscopic studies by space-based long-slit observations. Using adaptive-optics-corrected integral field spectroscopy from the OSIRIS instrument at the W. M. Keck Observatory, we map the line-of-sight kinematics over the entire old stellar eccentric disk orbiting the supermassive black hole (SMBH) at a distance of r < 4 pc. The peak velocity dispersion is 381 ± 55 km s−1, offset by 0.″13 ± 0.″03 from the SMBH, consistent with previous high-resolution long-slit observations. There is a lack of near-infrared (NIR) emission at the position of the SMBH and young nuclear cluster, suggesting a spatial separation between the young and old stellar populations within the nucleus. We compare the observed kinematics with dynamical models from Peiris & Tremaine. The best-fit disk orientation to the NIR flux is [θ

l
, θ

i
, θ

a
] = [−33° ± 4°, 44° ± 2°, −15° ± 15°], which is tilted with respect to both the larger-scale galactic disk and the best-fit orientation derived from optical observations. The precession rate of the old disk is Ω
P
= 0.0 ± 3.9 km s−1 pc−1, lower than the majority of previous observations. This slow precession rate suggests that stellar winds from the disk will collide and shock, driving rapid gas inflows and fueling an episodic central starburst as suggested in Chang et al.
L’influence de la rémunération fixe sur la motivation autonome au travers du soutien organisationnel perçu et ses conséquences en termes d’engagement et de satisfaction au travail
Authors: Roussillon Soyer Claude , Roussel Patrice , Charbonnier-Voirin Audrey , Bentein Kathleen , Balkin David B. 
Published: February 2018

Cet article, en mobilisant la théorie de l’auto-détermination, a pour objectif d’une part de comprendre comment le niveau de rémunération fixe peut influencer la motivation autonome et d’autre part d’examiner les conséquences de la motivation autonome sur l’engagement puis la satisfaction au travail. Les mécanismes qui interviennent dans la relation entre la rémunération fixe et la satisfaction au travail, sont (1) le support organisationnel perçu (SOP) par les salariés, (2) leur motivation autonome et (3) leur engagement au travail. Les résultats de l’étude menée sur un échantillon de 147 salariés d’une coopérative vinicole supportent l’hypothèse que le SOP médiatise totalement la relation entre la rémunération fixe et la motivation autonome, de telle sorte que la rémunération influence positivement la motivation au travers de son effet sur le SOP. Cette recherche supporte également les hypothèses que la motivation autonome médiatise totalement la relation entre le SOP et l’engagement, puis que l’engagement médiatise totalement la relation entre la motivation autonome et la satisfaction au travail.
Une nouvelle technique pour la cure chirurgicale de la rupture des ligaments croisés du genou chez le chien
Authors: Bornet Jean-Pierre 
Published: February 2018

L'auteur après avoir donné un bref historique de l'évolution des techniques chirurgicales relatives à la rupture des ligaments croisés du genou et des rappels anatomiques procède à une étude de la cinétique de l'articulation et de l’étiopathogénie.
A la lumière des études précédentes l’auteur présente une nouvelle technique dont le principe est la stabilisation complète de l’articulation du genou à l'aide d’un monofil synthétique restituant les deux ligaments croisés surtout quant à leurs fonctions respectives.
Il s’agit d'une technique intracapsulaire faisant appel à des tunnelisations des condyles fémoraux et de la tête du tibia. Un soin tout particulier est apporté à la description du forage de ces tunnels ainsi qu’à la mise en place de la prothèse et la stabilisation de l'articulation.
Effets de l'adjonction d'huile de maïs à un régime alimentaire pour veaux de boucherie : I. Conséquences zootechniques
Authors: Joussellin Wilfrid , Aurousseau Bernard , Bauchart Dominique , Poissonnet P. 
Published: February 2018

Eighty young male calves (French Friesian breed) were used to determine linoleic acid [C18 : 2 (n-6)] requirements and were allocated to one of the four following regimens :
Group (1) : milk substitute diet without soya lecithin (diet A) containing 2.6 % of lipids as linoleic acid ;
Group (2) : same diet but with soya lecithin (diet B) including 3.5 % of lipids as linoleic acid ;
Group (3) : same diet as in group 2 (diet B) but additionally, 5 ml of com oil were given on each morning feeding starting day 63 after the beginning of the experiment ;
Group (4) : same diet as in group 3 but 5 ml of com oil were given starting on day 6.
Both rate and efficiency of live-weight gain were improved by additionnal com oil. This increase was only significant (p < 0,05) in group 3. There were no significant differences between groups for any of the carcass characteristics studied.
Before 55 days of age, polyinsaturated fatty acids requirements were met by both diets (with or without soya lecithin) which delivered approximately 1.2 to 1.6 % of total energy as linoleic acid.
For calves older thas 2 months, linoleic acid requirements seemed to be within 1.8-2.1 % of total energy.
Addition of 5 ml of com oil to diet B starting on day 6 (group 4) induced an excess of linoleic acid and thus reduced the mean growth rate of the individuals.
Action in vitro de l'aflatoxine Bi sur les spermatozoïdes du taureau
Authors: Lemarinier Sylvie , Jacquet Jean 
Published: February 2018

Les spermatozoïdes des animaux domestiques, tels qu'ils sont préparés pour l'insémination artificielle, constituent un matériel facile à se procurer, sûrement et largement utilisable dans l'expérimentation biologique, en toxicologie notamment.
L’aflatoxine Bi arrête les mouvements des spermatozoïdes de taureau en 18 h avec 2,5 µg par ml et en 30 min à 45-50 µg par ml. Le contact à 37° C au taux de 50 µg par ml provoque des lésions ultrastructurales à partir de 30 min. Elles atteignent tous les spermatozoïdes en 2 h. La membrane plasmique de l’acrosome et les mitochondries de la pièce intermédiaire sont particulièrement fragiles.
Échotomographie en temps réel de l’utérus chez la jument. Application au diagnostic de gestation
Authors: Valon François Xavier 
Published: February 2018

L’échotomographic en temps réel du tractus génital par voie transrectale chez la jument a permis aux auteurs de définir les modifications physiologiques et pathologiques de cet organe. Dès le 115e jour après ta fécondation un diagnostic de gestation peut être établi. Ainsi la fréquence des résorptions embryonnaires a été précisée : pour plus de 500 diagnostics positifs, elle a été inférieure h 5 H. De plus une conduite raisonnée et efficace est proposée lors de gémellité.
Enfin des images univoques de lésions utérines sont décrites et leur corrélation avec la fécondité de la femelle est discutée.
Le renard, indicateur biologique de la pollution de l’environnement par les composés organo-chlorés et les métaux lourds
Authors: Venant A. , Cumont G. , Blancou Jean , Richou-Bac Lucien , Feinberg M. 
Published: February 2018

Fox could be convenient for an ecologial monitoring because of its biology. A study with two populations of foxes from different area permits to check this possibility. Encephalon and head muscles from dead animals, killed in rabies prophylaxis plan, were analysed. Samples from plain district where organochlorine pesticides were intensively used, are contamined with heptachlore and dieldrine, whereas samples from mountain area are free of contamination.
No signifiant differences for mercury, cadmium, and lead concentrations can be demonstrated either between samples types or regions because probably no special contamination exists with heavy metals.
Méthodes d'identification et de dosage de substances thyréostatiques dans les aliments pour bovins
Authors: Comsa Eugénie , Roche-Fondeur S. , Mazzocut D. , Michaux Jean-Michel , Mouthon Gilbert 
Published: February 2018

Trials for identification and quantity determination of thyreostatic compounds are experimented on bovine alimentary powders.
Among the three methods considered, the high performance liquid chromatography seems to be the most appropriate to the detection of such substances. In this study, this method is applied to the Methylthiouracil but is also suitable for the thyreostatics compounds witch may be added by fraud in the cattle's food.