bluuebunny/crossref_metadata_2025_split huggingface dataset:
ABC Transporters: Regulation and Association with Multidrug Resistance in Hepatocellular Carcinoma and Colorectal Carcinoma
Authors: Ceballos María Paula , Rigalli Juan Pablo , Ceré Lucila Inés , Semeniuk Mariana , Catania Viviana Alicia , Ruiz María Laura 
Published: February 2018

:For most cancers, the treatment of choice is still chemotherapy despite its severe adverse effects, systemic toxicity and limited efficacy due to the development of multidrug resistance (MDR). MDR leads to chemotherapy failure generally associated with a decrease in drug concentration inside cancer cells, frequently due to the overexpression of ABC transporters such as P-glycoprotein (P-gp/MDR1/ABCB1), multidrug resistance-associated proteins (MRPs/ABCCs), and breast cancer resistance protein (BCRP/ABCG2), which limits the efficacy of chemotherapeutic drugs. The aim of this review is to compile information about transcriptional and post-transcriptional regulation of ABC transporters and discuss their role in mediating MDR in cancer cells.:This review also focuses on drug resistance by ABC efflux transporters in cancer cells, particularly hepatocellular carcinoma (HCC) and colorectal carcinoma (CRC) cells. Some aspects of the chemotherapy failure and future directions to overcome this problem are also discussed.
Teaching English Using Poetry: An Alternative to Implement Contextual Teaching and Learning
Authors: Samanik Samanik 
Published: February 2018

This paper describes poetry as an alternative to implement Contextual Teaching and Learning (CTL). CTL places learning and learning activities in a real-life context, incorporating not only what is learned but also why students should learn it. Meanwhile, poetry is chosen for its authenticity, in which, all nations have their own record on poetry. The classroom activities which involve poetry are poetry production (writing), poetry performance (reading), and poetry appreciation (speaking). By using poetry, learning processes are expected to meet the seven main components of effective learning: constructivism, questioning, inquiry, learning community, modeling, and authentic assessment. Moreover, the learning process can develop not only language skills but also critical thinking skill.
Keywords: Contextual Teaching and Learning (CTL), poetry, components of ideal teaching and learning
A Strategic Approach to Target Capital Investment on Facility Assets: Literature Review
Authors: Rincon Jorge L. , Lavy Sarel , Fernandez-Solis Jose. L 
Published: February 2018

ABSTRACT
Analysis of a strategic planning framework, proposed by Edward Zielinski, focused on reducing operational costs in Facility Management (FM) through using long-term best practices in capital investment. This paper indicates how that framework may assist in the FM decision process of capital investment allocation. The framework structure is integrated through: (1) alignment of FM decisions to the organizational strategy; (2) measuring FM performance with a data-driven approach; and (3) standardization of budgeting processes as support for FM credibility. The authors use a Structured Literature Review to investigate how previous research of the topic and subtopics supports the framework's objectives. Emphasis on referenced case studies aims to investigate the applicability of this framework by FM practitioners. The framework is fully applicable to FM operations. The case study analysis suggests it is a powerful tool for supporting capital investment decisions in organizations. Benefits foreseen include: value creation through alignment of FM decisions to organizational goals, risk control in short-, mid- and long-term FM decisions, creation of structured procedures for FM data acquisition supporting stakeholders' decisions, increased FM credibility through budgeting process standardization, improvement of FM operations efficiency, and senior management awareness of FM priorities. This paper encourages FM practitioners to structure their daily operations by addressing the three most challenging aspects of this profession: understand the client, capitalize valuable knowledge, and secure funding.
Application of Lean Six Sigma to Improve Service in Healthcare Facilities Management: A Case Study
Authors: Shirey Will T. , Sullivan Kenneth Timothy , Lines Brian , Smithwick Jake 
Published: February 2018

ABSTRACT
The purpose of this paper is to present a case study on the application of the Lean Six Sigma (LSS) quality improvement methodology to facilities management (FM) services at a healthcare organization. Research literature was reviewed concerning whether or not LSS has been applied in healthcare-based FM, but no such studies have been published. This paper aims to address the lack of an applicable methodology for LSS intervention within the context of healthcare-based FM. The Define, Measure, Analyze, Improve, and Control (DMAIC) framework was followed to test the hypothesis that LSS can improve the service provided by an FM department responsible for the maintenance and repair of furniture and finishes at a large healthcare organization in the southwest United States of America. Quality improvement curricula and resources offered by the case study organization equipped the FM department to apply LSS over the course of a five-month period. Qualitative data were gathered from pre- and post-intervention surveys while quantitative data were gathered with the Organization's computerized maintenance management system (CMMS) software. Overall, LSS application proved to be useful for the intended purpose. The authors proposes that application of LSS by other FM departments to improve their services could also be successful, which is noteworthy and deserving of continued research.
Migración y masculinidades: análisis de la experiencia de un joven que emigró por amor
Authors: Torre Cantalapiedra Eduardo , Rodríguez de Jesús Cynthia 
Published: February 2018

Los estudios sobre las migraciones de los hombres se han enfocado en las movilidades laborales. En contraste, nuestro objetivo es detectar y analizar los malestares que experimentan en su migración los varones jóvenes que se movilizan sobre todo por motivos extraeconómicos, en relación con el referente de la masculinidad hegemónica y el estereotipo del migrante laboral, en función de sus respectivas identidades masculinas. Analizamos el relato de vida de un joven que emigró para establecer una relación de pareja y experimentó malestares derivados de sus interacciones con personas que asumían el esquema de masculinidad tradicional y los estereotipos de la migración. Además, analizamos su construcción de una identidad masculina alternativa.
Feminidad y uso de la fuerza: la fabricación de una heroína a partir de la serie de televisión Nikita
Authors: Calandrón Sabrina 
Published: February 2018

El objetivo central de este artículo es mostrar las variadas y complejas relaciones entre el uso de la fuerza física y la feminidad. Se analizan las concepciones culturales sobre las mujeres dedicadas al ejercicio sistemático de la violencia corporal y letal en historias de ficción televisivas de acción. A partir del caso paradigmático de la serie estadounidense Nikita, realizada en 2010 y transmitida en varios países de Latinoamérica, ofrecemos una mirada crítica de las visiones clásicas que explican la fuerza física como marca exclusiva de masculinidad. La musculación física, la destreza aeróbica, la activación sexual y la autonomía de las mujeres respecto de los protagonistas varones en historias ficticias de acción colaboran a construir una narrativa de expresión de la feminidad contemporánea.
Penyuluhan Program Literasi Informasi Kesehatan dalam Meningkatkan Kualitas Sanitasi bagi Masyarakat di Kaki Gunung Burangrang Kab. Bandung Barat
Authors: Prasanti Ditha , Fuady Ikhsan 
Published: February 2018

The ability of the community to access information needs is still uneven among urban people and rural communities. The ability to access information is an open door that must be open to be able to process and understand information, especially in this case is health information. Sanitation is one component of environmental health, a deliberate behavior to civilize a clean life to prevent humans directly touched with dirt and other hazardous waste materials, in the hope of maintaining and improving human health. Therefore, the authors perform Community Service activities entitled "Health Information Literacy Program Counseling in Improving the Quality of Sanitation for the Community at the foot of Mount Burangrang Kab. Bandung Barat."Community Service Activities has a purpose to produce outcomes, namely: 1) Provide concrete knowledge and insight about health information literacy in improving the quality of sanitation for people in West Bandung regency; 2) Providing comprehensive knowledge and insight about health information literacy in improving the quality of sanitation for people in West Bandung Regency.Method of PKM implementation conducted in this extension activity is ice breaking method; Workshop methods, lectures, and action studies. Keywords:Counseling, Literacy, Information, Health, Sanitation, West Bandung
Pemberdayaan Petani Lahan Gambut Melalui Proses Penjernihan Air Gambut
Authors: Widiastuti Tri , Latifah Siti 
Published: February 2018

Masyarakat di kawasan gambut umumnya mengandalkan air hujan untuk kebutuhan air bersih sehari-hari, akan tetapi ketersediaan air hujan menjadi terbatas pada musim kemarau, itu berarti tidak ada pilihan lain selain memanfaatkan air gambut yang mengalir di parit dilingkungan tempat tinggal mereka. Program KKN PPM bertujuan untuk memberdayakan petani melakukan penjernihan air gambut melalui program alih teknologi dan pendampingan petani. Penjernihan air gambut menggunakan bahan - bahan alami yang mudah didapatkan dilingkungan sekitar mereka, yaitu menggunakan kapur sirih, PAC dan Tawas sebagai koagulan penjernihan air dan juga menggunakan batu kerikil, pasir, arang dan ijuk sebagai filter pada proses penyaringan air. Sasaran utama adalah kelompok tani pengguna air gambut anggota Gapoktan Sumber Bersama yang berada di kampung Kembang Wonosari, dusun Karya 1, desa Kuala Dua. Kegiatan KKN PPM diselenggarakan selama 1bulan diikuti oleh 30 mahasiswa, Metode yang diterapkan adalah membuat plot percontohan, penyuluhan, bersama Poktan membuat sumur resapan, instalasi dan demo penjernihan air gambut. Pada 6 lokasi yang berbeda telah berhasil didirikan 6 buah instalasi pengolahan air gambut dan 6 sumur resapan, Melalui kegiatan KKN-PPM ini para petani telah dapat melakukan penjernihan air secara mandiri dan dapat mengatasi kesulitan air bersih pada musim kemarau. Kata kunci : air gambut, penjernihan, sumur
Pemberdayaan Kelompok Wanita Tani Melalui Optimalisasi Pemanfaatan Pekarangan dengan Budidaya Sayuran Organik Dataran Rendah Berbasis Kearifan Lokal dan Berkelanjutan
Authors: Minarni Endang Warih , Utami Darini Sri , Prihatiningsih Nur 
Published: February 2018

The specific purpose of this activity is to increase the motivation of women in improving the quality of life and self-reliance in the family by optimizing the yard with organic vegetable farming in the lowlands based on Local Wisdom and Sustainable. The strategy used was the empowerment of target groups with the approach of Participatory Rural Appraisal, methods of education, training, demonstration plots, assistance and equipped with learning by doing techniques. The materials presented were: (1) garden intensification technology with verticultur method, (2) organic vegetable cultivation technology based on liquid organic fertilizer, botanical pesticide and PGPR, (3) composting technology with enrichment of Trichoderma harzianum (Tricho-compos) activator of local microorganism, (4) technology of pest and disease control on environmentally friendly vegetable crops using botanical insecticides and microbial antagonists; (5) water use efficiency technology with drip irrigation; (6) good sorting, grading and packing technology, 7) empowerment technology to form groups and institutional strengthening and group management. The results of this activity are: (1) the target group / members The women farmer group has a very high curiosity about new information that can improve their standard of living,(2) technology transfer activities on the use of garden with organic vegetable cultivation received positive response from the members of the Group, (3) This devotional activity can encourage the pattern of mind and pattern of member action in organic vegetable cultivation by developing rural resources and sustainable local wisdom, (4) Verikultur cultivation technique with vertical paralon type on a land area of 10 m2 is economically profitable
Implementation of an Occupational Therapy Program for Alzheimer’s Disease Patients in France: Patients’ and Caregivers’ Perspectives
Authors: Corvol Aline , Netter Alix , Campeon Arnaud , Somme Dominique 
Published: February 2018

Background: The French National Alzheimer Plan 2008-2012 created specialized Alzheimer teams, which provide up to 15 sessions of cognitive rehabilitation in the patient’s home for 3 months. Sessions are conducted by an occupational therapist and a gerontological nursing assistant. Objectives: As the patient’s experience is one determinant of successful implementation, we explored the usefulness of these teams as viewed by the patient and his or her main caregiver. Methods: Thirteen patients and their caregiver, previously assisted by a specialized Alzheimer team, were individually given semi-structured interviews ( n = 26, duration 20 to 180 minutes). Results: Our study showed that although patients and caregiver had no initial expectations, most of them appreciated the support provided by the specialized Alzheimer teams. Patients valued the “human” component, and favored interventions that improved quality of life over those intended to maintain functional capacities. Caregivers observed improved mood and behavior in patients. Those involved in sessions felt empowered by contact with a specialized Alzheimer team. We discuss how patients’ and caregivers’ feedback influenced the implementation process through comprehensive use of the five dimensions of the RE-AIM framework. Conclusion: Whereas intervention by specialized Alzheimer teams was largely accepted by health care professionals, patients, and caregivers, its effectiveness is questioned in view of its deviation from the evidence-based model. Interviews with patients and caregivers shed light on some reasons for this deviation, as what they value in the intervention differs from the functional focus of the model.
Evaluating Peripersonal Space through the Functional Transcranial Doppler: Are We Paving the Way for Early Detecting Mild Cognitive Impairment to Dementia Conversion?
Authors: Marra Angela , Naro Antonino , Chillura Antonino , Bramanti Alessia , Maresca Giuseppa , De Luca Rosaria , Manuli Alfredo , Bramanti Placido , Calabrò Rocco Salvatore 
Published: February 2018

Background: Identifying the patients with mild cognitive impairment (MCI) who may develop dementia (MDC) is challenging. The study of peripersonal space (PPS) by using functional transcranial Doppler (fTCD) could be used for this purpose. Objective: To identify changes in cerebral blood flow (CBF) during motor tasks targeting PPS, which can predict MDC. Methods: We evaluated the changes in CBF in 22 patients with MCI and 23 with dementia [Alzheimer’s disease (AD) and vascular dementia (VaD)] during a motor task (passive mobilization, motor imagery, and movement observation) in which the hand of the subject moved forward and backward the face. Results: CBF increased when the hand approached the face and decreased when the hand moved from the face in the healthy controls (HCs). CBF changed were detectable only in patients with MCI but not in those with the AD and those who were MDC after 8-month follow-up. On the other hand, the patients with VaD presented a paradoxical response to the motor task (i.e., a decrease of CBF rather than an increase, as observed in HCs and MCI). Therefore, we found a modulation of PPS-related CBF only in HCs and patients with stable MCI (at the 8-month follow-up). Conclusions: fTCD may allow preliminarily differentiating and following-up the patients with MCI and MDC, thus allowing the physician to plan beforehand more individualized cognitive rehabilitative training.
Protective immunity of recombinant LipL21 and I-LipL21 against Leptospira interrogans serovar Autumnalis N2 infection
Authors: Kumari Anita , Premlatha Mallela Martha , Raja Veerapandian , Akino Mercy Charles Solomon , Sumathi Kalimuthusamy , Shariff Malini , Natarajaseenivasan Kalimuthusamy 
Published: February 2018

Introduction: Leptospirosis is a zoonotic disease caused by the spirochete of genus Leptospira with widespread distribution in tropical, subtropical and temperate zones. Leptospirosis is often confused with other febrile illnesses including jaundice, dengue, and malaria. Generally, the disease is often underdiagnosed or misdiagnosed. Though leptospirosis is curable with antibiotic treatment, the laboratory diagnosis of the disease is specialized and open to interpretation with multiple kits available to detect the different serological markers of Leptospira. Moreover, when leptospirosis is misdiagnosed, the disease can lead to multi-organ failure and may have fatal effects. There is a need for strategies to develop vaccines and prevent leptospirosis. In the present study, the immunogenic potential of leptospiral recombinant protein LipL21 (rLipL21) and its truncated form I-LipL21 (rI-LipL21) was evaluated.
Methodology: The recombinant proteins were established in cyclophosphamide treated BALB/c mice model infected with L. interrogans serovar Autumnalis strain N2.
Results: The vaccination study showed 66% and 83% survivability among mice immunized with rLipL21 and rI-LipL21 respectively and post-challenge with leptospiral strain N2 compared to control groups that showed 100% lethality. Additionally, a significant increase in antibody levels and cytokine levels (TNF-a, IFN-γ and IL-10) was observed evidencing a marked stimulation of both humoral and cell-mediated immune response in mice immunized with rLipL21/rI-LipL21 compared to whole cell leptospiral lysate (WCL).
Conclusions: This study evidenced protective immunization against leptospirosis with rLipL21 and rI-LipL21 recombinant proteins and are potential candidates for the development of leptospiral vaccine.
Bilan de trois années de fouille programmée du château de Marly
Authors: Heitzmann Annick 
Published: February 2018

L’histoire du château de Marly commence en 1679 et se termine par sa destruction en 1811, mais l’archéologie le fait revivre depuis 1865. La dernière campagne de fouille archéologique a été réalisée entre 2013 et 2015. Elle a concerné les jardins et les bâtiments. Dans les jardins, ont été étudiés : la grande cascade, dont la maçonnerie de plusieurs marches a été retrouvée, recouverte de mortier hydraulique dans lequel l’empreinte des marbres qui la décoraient était encore visible ; le bassin des Nappes et le bassin des Boules, tous les deux constitués d’un corroi de glaise. Deux bâtiments ont été fouillés. Le troisième pavillon du Levant d’une part (à l’est du Grand Miroir), dont toutes les fondations ont été dégagées, ainsi que le dispositif d’évacuation des eaux pluviales et les bases des arceaux supportant les berceaux de treillage. La fosse d’aisances du pavillon a livré un dépôt latrinaire et du mobilier archéologique. Le Pavillon royal d’autre part, sous lequel ont été trouvées les fosses d’aisances de l’appartement du roi, les caves de celui de la reine et cinq pierrées en étoile sous le salon central. Parmi les gravats qui comblaient ces excavations, il y avait des tessons de canalisation en terre cuite et des éléments de plâtres ou de pierres provenant des structures du château ou de son décor.
Fluctuations of radio occultation signals in sounding the Earth's atmosphere
Authors: Kan Valery , Gorbunov Michael E. , Sofieva Viktoria F. 
Published: February 2018

Abstract. We discuss the relationships that link the observed fluctuation
spectra of the amplitude and phase of signals used for the radio occultation
sounding of the Earth's atmosphere, with the spectra of atmospheric
inhomogeneities. Our analysis employs the approximation of the phase screen
and of weak fluctuations. We make our estimates for the following
characteristic inhomogeneity types: (1) the isotropic Kolmogorov turbulence
and (2) the anisotropic saturated internal gravity waves. We obtain the
expressions for the variances of the amplitude and phase fluctuations of
radio occultation signals as well as their estimates for the typical
parameters of inhomogeneity models. From the GPS/MET observations, we
evaluate the spectra of the amplitude and phase fluctuations in the altitude
interval from 4 to 25 km in the middle and polar latitudes. As
indicated by theoretical and experimental estimates, the main contribution
into the radio signal fluctuations comes from the internal gravity waves. The
influence of the Kolmogorov turbulence is negligible. We derive simple
relationships that link the parameters of internal gravity waves and the
statistical characteristics of the radio signal fluctuations. These results
may serve as the basis for the global monitoring of the wave activity in the
stratosphere and upper troposphere.
Black carbon and mineral dust in snow cover on the Tibetan Plateau
Authors: Zhang Yulan , Kang Shichang , Sprenger Michael , Cong Zhiyuan , Gao Tanguang , Li Chaoliu , Tao Shu , Li Xiaofei , Zhong Xinyue , Xu Min , Meng Wenjun , Neupane Bigyan , Qin Xiang , Sillanpää Mika 
Published: February 2018

Abstract. Snow cover plays a key role for sustaining ecology and society in mountainous regions. Light-absorbing particulates (including black carbon, organic carbon, and mineral dust) deposited on snow can reduce surface albedo and contribute to the near-worldwide melting of snow and ice. This study focused on understanding the role of black carbon and other water-insoluble light-absorbing particulates in the snow cover of the Tibetan Plateau (TP). The results found that the black carbon, organic carbon, and dust concentrations in snow cover generally ranged from 202 to 17 468 ng g−1, 491 to 13 880 ng g−1, and 22 to 846 µg g−1, respectively, with higher concentrations in the central to northern areas of the TP. Back trajectory analysis suggested that the northern TP was influenced mainly by air masses from Central Asia with some Eurasian influence, and air masses in the central and Himalayan region originated mainly from Central and South Asia. The relative biomass-burning-sourced black carbon contributions decreased from ∼ 50 % in the southern TP to ∼ 30 % in the northern TP. The relative contribution of black carbon and dust to snow albedo reduction reached approximately 37 and 15 %, respectively. The effect of black carbon and dust reduced the snow cover duration by 3.1 ± 0.1 to 4.4 ± 0.2 days. Meanwhile, the black carbon and dust had important implications for snowmelt water loss over the TP. The findings indicate that the impacts of black carbon and mineral dust need to be properly accounted for in future regional climate projections, particularly in the high-altitude cryosphere.
At the End of the Day: In Memory of Miriam Polster
Authors: Gold Eva , Zahm Steve 
Published: February 2018

Abstract
Miriam Polster, one of the most well-known Gestalt therapists in the world, died on December 19, 2001. Her writing and teaching have influenced generations of Gestalt therapists over the past 30 years. She was not only well known, but well loved. We were asked to write about Miriam's life, the highlights of her professional career, and her contributions to Gestalt therapy. We have included the words of others who also knew and loved Miriam, including excerpts from answers to questions about Miriam and their life together provided by her husband, colleague, and life partner, Erving Polster. We have attempted to capture some of what made Miriam so special to so many.