bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cardiomyopathy, oxidative stress and impaired contractility in a rheumatoid arthritis mouse model
Authors: Pironti Gianluigi , Bersellini-Farinotti Alex , Agalave Nilesh M , Sandor Katalin , Fernandez-Zafra Teresa , Jurczak Alexandra , Lund Lars H , Svensson Camilla I , Andersson Daniel C 
Published: May 2018

ObjectivesPatients with rheumatoid arthritis (RA) display an increased risk of heart failure independent of traditional cardiovascular risk factors. To elucidate myocardial disease in RA, we have investigated molecular and cellular remodelling of the heart in an established mouse model of RA.MethodsThe collagen antibody-induced arthritis (CAIA) RA mouse model is characterised by joint inflammation and increased inflammatory markers in the serum. We used CAIA mice in the postinflammatory phase that resembles medically controlled RA or RA in remission. Hearts were collected for cardiomyocyte isolation, biochemistry and histology analysis.ResultsHearts from mice subjected to CAIA displayed hypertrophy (heart/body weight, mean±SD: 5.9±0.8vs 5.1±0.7 mg/g, p<0.05), fibrosis and reduced left ventricular fractional shortening compared with control. Cardiomyocytes from CAIA mice showed reduced cytosolic [Ca2+]i transient amplitudes (F/F0, mean±SD: 3.0±1.2vs 3.6±1.5, p<0.05) that was linked to reductions in sarcoplasmic reticulum (SR) Ca2+ store (F/F0, mean±SD: 3.5±1.3vs 4.4±1.3, p<0.01) measured with Ca2+ imaging. This was associated to lower fractional shortening in the cardiomyocytes from the CAIA mice (%FS, mean±SD: 3.4±2.2 vs 4.6%±2.3%, p<0.05). Ca2+ handling proteins displayed oxidation-dependent posttranslational modifications that together with an increase in superoxide dismutase expression indicate a cell environment with oxidative stress.ConclusionsThis study shows that inflammation during active RA has long-term consequences on molecular remodelling and contractile function of the heart, which further supports that rheumatology patients should be followed for development of heart failure.
Preliminary outcomes of single antiplatelet therapy for surface-modified flow diverters in an animal model: analysis of neointimal development and thrombus formation using OCT
Authors: Matsuda Yoshikazu , Jang Dong-Kyu , Chung Joonho , Wainwright John Michael , Lopes Demetrius 
Published: May 2018

ObjectiveTo evaluate the rate of neointimal development and thrombus formation of surface-modified flow diverters in single antiplatelet therapy (SAPT) using optical coherence tomography (OCT) in a porcine model.MethodsWe divided 10 experimental pigs into two groups. One group (n=6) received dual antiplatelet therapy (DAPT) and the other group (n=4) received SAPT. Four stents (two per carotid artery) were implanted in both groups. The stents used were the Pipeline Flex embolization device (PED Flex), Pipeline Flex with Shield technology (PED Shield), and the Solitaire AB stent. All animals underwent weekly angiography and OCT. The OCT data were analyzed using the following measurements: neointimal ratio ((stent – lumen area)/stent area), stent-coverage ratio (number of stent struts covered by neointima/total stent struts), and the presence or absence of thrombus formation per 1 mm cross-section.ResultsPED Flex and Shield in the SAPT group had higher neointimal ratios than in the DAPT group (P<0.001, respectively). In the DAPT group, the speed of endothelial growth on day 7 in the PED Shield group was higher than that in the PED Flex group (P<0.001). In the SAPT group, PED Flex demonstrated significantly more thrombus formation on day 7 than PED Shield (P<0.001).ConclusionsThe PED Shield stent showed faster endothelial growth than the other devices and comparable neointimal volume. There was significantly less thrombus formation on PED Shield than PED Flex when using SAPT in a porcine model.
Marked paraneoplastic hypereosinophilia associated with a low‐grade, metastatic canine mast cell tumour
Authors: Musser Margaret , Berger Erika , Flaherty Heather A , Fox Leslie , Johannes Chad M 
Published: May 2018

An 11‐year‐old, female, spayed labrador retriever was presented to the Iowa State University Oncology Service for evaluation of a rapidly expanding mass located near the right prescapular lymph node. A Patnaik grade I mast cell tumour (mitotic index <3/10 high‐power fields) had been completely excised from the right antebrachium five months before presentation. Cytological evaluation of aspirates from the healed incision site and the new mass revealed mast cells with marked eosinophilic infiltration consistent with local recurrence and presumed lymph node metastasis. A complete blood count revealed markedly elevated eosinophils (23.96×103 cells/µl, reference interval 0–0.75). The patient was diagnosed with a histologically low‐grade, biologically high‐grade cutaneous, metastatic mast cell tumour with paraneoplastic hypereosinophilia. Changes in the magnitude of peripheral hypereosinophilia frequently paralleled tumour response to treatment with multiple antineoplastic agents. Nine months after initiating chemotherapy, treatment was discontinued due to declining quality of life.
Validation of a commercial 1,2‐o‐dilauryl‐rac‐glycero glutaric acid‐(6’‐methylresorufin) ester lipase assay for diagnosis of canine pancreatitis
Authors: Goodband Emily L , Serrano Gonçalo , Constantino‐Casas Fernando , Archer Joy , Watson Penny J , Williams Tim L 
Published: May 2018

The objectives of this study were fourfold: technical validation of a commercial canine 1,2‐o‐dilauryl‐rac‐glycero glutaric acid‐(6’‐methylresorufin) ester (DGGR) lipase assay, to calculate a reference interval for DGGR lipase by the indirect a posteriori method, to establish biological validity of the assay, and to assess agreement between DGGR lipase and specific canine pancreatic lipase (Spec cPL) assays. Dogs with histologically confirmed acute pancreatitis (n=3), chronic pancreatitis (n=8) and normal pancreatic tissue (n=7) with stored (−80°C) serum samples were identified. Relevant controls were selected. Precision, reproducibility and linearity of DGGR lipase, and the effect of sample haemolysis and freezing, were assessed. Sensitivity and specificity of DGGR lipase and Spec cPL were determined. Agreement between these two parameters was calculated using Cohen's kappa coefficient (κ). The DGGR lipase assay demonstrated excellent precision, reproducibility and linearity. Sample haemolysis and storage at −80°C for 12 months did not influence the assay. DGGR lipase (>245IU/l) and Spec cPL (>400µg/l) both showed poor sensitivity but excellent specificity for acute pancreatitis, and poor to moderate sensitivity but excellent specificity for chronic pancreatitis. Substantial agreement (κ=0.679) was found between DGGR lipase and Spec cPL. The validated DGGR lipase assay had similar sensitivity and specificity for the diagnosis of acute and chronic pancreatitis to Spec cPL. DGGR lipase is a reliable alternative to Spec cPL for the diagnosis of pancreatitis.
<b>The characteristics, representativeness, function and conservation importance of tropical dry evergreen forest on India’s Coromandel Coast</b>
Authors: Everard Mark 
Published: May 2018

The central area of the Coromandel Coast, southeastern India, has been subject to a very long history of human habitation and land use change, substantially reducing the coverage of native forest. There are polarised views about definitive characteristics of native tropical dry evergreen forest (TDEF), albeit agreement that the habitat type is locally characteristic though now severely reduced, fragmented and degraded. A literature review was undertaken to determine the evolutionary origins of TDEF as well as its characteristics. A combination of both natural and human factors gives rise to TDEF, explaining the heterogeneity of existing stands even in close proximity to each other. Religious shrines are often associated with ‘sacred groves’, which are influential in the survival of stands of TDEF. These remaining stands are highly fragmented across the wider landscape and subject to species invasions from adjacent habitats as well as increasing human pressures. On the basis of existing evidence, it is not possible to describe TDEF through a definitive community of tree species, though typical constituent species are listed. TDEF may therefore be representative of a larger biome, as for example ‘tropical rainforest’, rather than a specific vegetation type. Nevertheless, there is general consensus about the importance of restoring TDEF, including its many associated plant and animal species, many of which have medicinal, spiritual and other uses and meanings. Regardless of biological definitions of TDEF, the functions it performs and the diversity of ecosystem services that it provides afford it substantial importance and reinforce the case for its protection and restoration. Successful local restoration activities highlight the feasibility of regeneration of TDEF, even from severely degraded and eroded land, and the associated regeneration of ecological and socio-economic values.
<b>Species diversity and abundance of birds on Bharathiar University Campus, Tamil Nadu, India</b>
Authors: Pragasan L. Arul , Madesh M. 
Published: May 2018

University campuses play a significant role in the conservation of avifaunal diversity, but there are very few studies on birds of such local biodiversity hotspots in India. Here, we document the patterns of abundance and species diversity of birds in Bharathiar University campus located in western Tamil Nadu, India. Birds were sampled using point counts. A total of 37 species belonging to 23 families were recorded from 144 point count samples. Mean species richness per point count sample was 13.85±0.47 species (±SD), and Shannon diversity index (Hʹ) was 0.74. This study provides baseline data for monitoring the avifauna in the university campus, and demonstrates the importance of university campuses in bird conservation.
<b>Home range and spatial organization by the Hoary Fox <I>Lycalopex vetulus</I> (Mammalia: Carnivora: Canidae): response to social disruption of two neighboring pairs</b>
Authors: Dalponte Julio C. , Lima Herson S. , Klorfine Stuart , Da Luz Nelton C. 
Published: May 2018

The Hoary Fox Lycalopex vetulus, is a small omnivore-insectivore canid inhabiting open environments/areas of the Brazilian savannah, whose spatial organization and territoriality is still unknown. Space use and social organization of two breeding pairs with adjacent home ranges were determined through radio tracking from October 2002 to April 2003 in a mosaic of cultivated pastures and Cerrado vegetation in eastern Mato Grosso, Brazil. Home ranges were 140–299 ha in size, with individual areas of the male and female in each breeding pair overlapping extensively. After the death of both individuals of one pair, the neighboring pair progressively occupied the vacant space, expanding markedly its range into about half the area originally occupied by the previous pair. Factors driving a pair of Hoary Foxes to expand their territory into a vacant area after death of the neighboring pair were not clearly determined. Absence of territorial defence, however, could have contributed to the range shift observed. This is the first time that the response of neighboring foxes to social disruption of an adjacent pair has been documented for Hoary Foxes.
<b>Early stages and larval host plants of some northeastern Indian butterflies</b>
Authors: Karmakar Tarun , Nitin R. , Sarkar Vivek , Baidya Sarika , Mazumder Subhajit , Chandrasekharan V. K. , Das Rudraprasad , Kumar G.S. Girish , Lokhande Swapnil , Veino Joyce , Veino Lightson , Veino Rakoveine , Mirza Zeeshan , Sanap Rajesh V. , Sarkar Bimal , Kunte Krushnamegh 
Published: May 2018

Eastern Himalaya and northeastern India are part of two global biodiversity hotspots, yet the critical butterfly-plant associations and early stages of most butterfly species in this region are poorly recorded. We have reported early stages and larval host plants of 78 butterfly species, some of which are rare and endemic, providing specific information on spatial and temporal details associated with these records. These records contribute region-specific information on Indian butterflies, which may be useful in basic ecological and conservation studies in the future.
<b>An account of the occurrence of Wedge Sea Hare <I>Dolabella auricularia</I> (Lightfoot, 1786) (Gastropoda: Aplysiidae) from Andaman Islands, India</b>
Authors: Pandey Vikas , Thiruchitrambalam Ganesh , Savurirajan M. , Lakra Raj Kiran , Equbal Jawed , Satyam Kunal , Sainath P. Shanmukha , Samson Rokkarukala 
Published: May 2018

In the present article we provide a detailed account on the occurrence of Wedge Sea Hare Dolabella auricularia, from two different locations (Hut Bay and Burmanallah) of Andaman Islands. This species has been reported by Rao (2003) from Andamans but there is no specific location mentioned. First occurrence of this species was observed in Hut Bay coast of Little Andaman and after a three month interval a group of Wedge Sea Hares were again spotted from Burmanallah, South Andaman. In the present article we have given a detailed account on the occurrence and morphological features with field and laboratory pictures of D. auricularia and its biomedical importance based on literature.
<b>Clarke’s Morning Glory <I>Ipomoea clarkei</I> Hook.f. (Convolvulaceae): addition to the flora of Eastern Ghats</b>
Authors: Rasingam L. , Swamy J. , Sankara Rao M. 
Published: May 2018

Ipomoea clarkei Hook.f. is an endemic species to Maharashtra state is reported here as a new addition to the Flora of Eastern Ghats from Nagarjuna Sagar Srisailam Tiger Reserve, India. The detail description, notes, distributional map and colour plates are provided for easy identification.
<b>Distribution of <I>Rhododendron falconeri</I> Hook. F. (Ericales: Ericaceae) in Yuksam-Dzongri trekking corridor of Khangchendzonga National Park, Sikkim, India</b>
Authors: Pandey Aseesh , Badola Hemant K. 
Published: May 2018

Rhododendron falconeri Hook.f. [= Azalea falconeri (Hook.f.) Kuntze] is a potential candidate for conservation in Sikkim State due to its threatened status and startling features especially during the flowering period. We studied the status and habitats for R. falconeri across the Yuksam-Dzongri trekking corridor in Khangchendzonga National Park, Sikkim eastern Himalaya. These findings will help to develop conservation strategies for R. falconeri and landscape beautification sustainability in the long run.
<b>Mugger Crocodile <I>Crocodylus palustris</I> Lesson, 1831 (Reptilia: Crocodilia: Crocodylidae) in river Saberi of Godavari system in southern Odisha, India: conservation implications</b>
Authors: Debata Subrat , Purohit Swetashree , Mahata Anirban , Jena Sudheer Kumar , Palita Sharat Kumar 
Published: May 2018

A biodiversity survey was conducted in Koraput District of southern Odisha between August 2014 and July 2017. During the survey, occurrence of Mugger or Marsh Crocodile Crocodylus palustris was ascertained from five localities in a stretch of 23km of river Saberi, a tributary of the Godavari River system. The area is in the Gupteswar proposed reserve forest of Odisha, and forms a boundary with Kanger Ghat National Park of Chhattisgarh State. The geographic region offers possible scope for long term ecological monitoring jointly by wildlife organizations of Odisha and Chhattisgarh in collaboration with Central University of Orissa. For long-term conservation of the species, activities may be initiated with annual monitoring of crocodile populations involving local people, and creating awareness about the Schedule-I status of crocodiles under the Wildlife Protection Act, 1972.
Modifications of 2:1 Clay Minerals in a Kaolinite-Dominated Ultisol under Changing Land-Use Regimes
Authors: Austin Jason C. , Perry Amelia , Richter Daniel D. , Schroeder Paul A. 
Published: May 2018

AbstractChemical denudation and chemical weathering rates vary under climatic, bedrock, biotic, and topographic conditions. Constraints for landscape evolution models must consider changes in these factors on human and geologic time scales. Changes in nutrient dynamics, related to the storage and exchange of K+ in clay minerals as a response to land use change, can affect the rates of chemical weathering and denudation. Incorporation of these changes in landscape evolution models can add insight into how land use changes affect soil thickness and erodibility. In order to assess changes in soil clay mineralogy that result from land-use differences, the present study contrasts the clay mineral assemblages in three proximal sites that were managed differently over nearly the past two centuries where contemporary vegetation was dominated by old hardwood forest, old-field pine, and cultivated biomes. X-ray diffraction (XRD) of the oriented clay fraction using K-, Mg-, and Na-saturation treatments for the air-dried, ethylene glycol (Mg-EG and K-EG) solvated, and heated (100, 350, and 550°C) states were used to characterize the clay mineral assemblages. XRD patterns of degraded biotite (oxidized Fe and expelled charge-compensating interlayer K) exhibited coherent scattering characteristics similar to illite. XRD patterns of the Mg-EG samples were, therefore, accurately modeled using NEWMOD2® software by the use of mineral structure files for discrete illite, vermiculite, kaolinite, mixed-layer kaolinite-smectite, illite-vermiculite, kaolinite-illite, and hydroxy-interlayered vermiculite. The soil and upper saprolite profiles that formed on a Neoproterozoic gneiss in the Calhoun Experimental Forest in South Carolina, USA, revealed a depth-dependence for the deeply weathered kaolinitic to the shallowly weathered illitic/vermiculitic mineral assemblages that varied in the cultivated, pine, and hardwood sites, respectively. An analysis of archived samples that were collected over a five-decade growth period from the pine site suggests that the content of illite-like layers increased at the surface within 8 y. Historical management of the sites has resulted in different states of dynamic equilibrium, whereby deep rooting at the hardwood and pine sites promotes nutrient uplift of K from the weathering of orthoclase and micas. Differences in the denudation rates at the cultivated, pine, and hardwood sites through time were reflected by changes in the soil clay mineralogy. Specifically, an increased abundance of illite-like layers in the surface soils can serve as a reservoir of K+.
Physıcal activity level in element ary education second level children, physical self description and self-esteem <p>İlköğretim II. kademe çocuklarda fiziksel aktivite düzeyi, kendini fiziksel tanımlama ve benlik saygısı
Authors: Baydemir Barış , Yurdakul Hüseyin Özden , Özer Kamil 
Published: May 2018

The aim of this study is to analyze the factors affecting the physical ego of children between the age of 11-13 considering the levels of physical activity and physical perception. According to results of 2010-2011 Çanakkale National Education Questionnaire; 11 schools which have high and low economic status were randomly selected. To determine the reason of the differences between groups, Post-hoc Bonferroni test was used when the variances were homogenous and Dunnett’s T3 test was used when the variances were not homogenous for the each independent variable. Pearson Correlation was used in order to find relationship between the independent groups. Alpha level was set to 0.05 for all calculations. According to the main findings of the research, it was found that the levels of physical activity, physical self description and self confidence of students differentiated in terms of gender and socioeconomic levels of the students. Extended English summary is in the end of Full Text PDF (TURKISH) file. ÖzetBu çalışmanın amacı fiziksel benliği etkileyen faktörlerin 11-13 yaş çocuklarda fiziksel aktivite ve fiziksel algılama düzeyine göre inceleyerek sosyo-ekonomik düzeyin fiziksel aktivite ve fiziksel uygunluk düzeyine etkisini ortaya koymaktır. 2010-2011 Çanakkale İl Milli Eğitim veli anket sonuçları çerçevesinde alt ve üst gelir grubuna sahip okullardan; merkezden ve ilçelerden rastgele 11 okul seçilmiştir. Gruplar arasındaki anlamlı farklılığın nedenini belirlemek için de her bir bağımsız değişken adına varyansların homojen olduğu durumlarda çoklu karşılaştırma testlerinden Post-hoc Bonferroni testi, varyansların homojen olmadığı durumlarda ise Dunnett’s T3 testi uygulanmıştır. Bağımsız gruplar arasındaki ilişki için Pearson Mometler çarpım korelasyonu uygulanmış, tüm istatistik hesaplamalarda anlamlılık düzeyi 0,05 olarak kabul edilmiştir. Araştırma sonucunda; 11-13 yaş çocuklarda fiziksel aktivite, kendini fiziksel tanımlama ve benlik saygısı düzeyleri, cinsiyete ve sosyo-ekonomik düzeye göre farklılaşmaların olduğu saptanmıştır.
Differential expression of FGFRs signaling pathway components in bladder cancer: A step toward personalized medicine
Authors: Ousati Ashtiani Z , Tavakkoly-Bazzaz J , Salami SA , Pourmand MR , Mansouri F , Mashahdi R , Pourmand G 
Published: May 2018

Abstract
Variations Improper activation and inappropriate expression of fibroblast growth factor receptors (FGFRs) in cancer suggests that they can act as therapeutic targets. Fibroblast growth factor receptor inhibitors are currently employed in clinical trials of different cancers. Regarding the essence and the importance of the personalized medicine, mainly mirrored by remarkable inter-individual variations in different populations, we aimed to perform a pilot study to address FGFR1 and FGFR3 expression levels and their correlation with the clinicopathological features in Iranian patients with bladder cancer (BC). Paired tumor and adjacent non tumor tissue samples along with their clinico-pathological parameters were obtained from 50 cases diagnosed with BC in different stages and grades. The mRNA expressions of FGFR1 and FGFR3 in tissue samples were determined by real-time polymerase chain reaction (real-time PCR). The expression levels of FGFR3 were significantly higher in tumor tissues when compared to adjacent normal tissues (p = 0.007), regardless of the stages and grades of the tumor. Over expression was associated with cigarette smoking (p = 0.037) and family history for cancer (p = 0.004). Decreased expression of FGFR1 was observed, remarkably evident in high-grade tumors (p = 0.047), while over expression was detected in low-grade samples. This pilot study clearly suggests that in Iranian BC patients FGFR1 and FGFR3 expression patterns are different, and also highly distinctive with regard to the tumor’s stage and grade. Such particular expression patterns may indicate their special values to be employed for interventional studies aiming targeted therapy. Further studies with a larger sample size are needed to validate our results.