bluuebunny/crossref_metadata_2025_split huggingface dataset:
EQ-5D Quality-of-Life Analysis and Cost-Effectiveness After Skull Base Meningioma Resection
Authors: Karsy Michael , Jensen Michael R , Guan Jian , Ravindra Vijay M , Bisson Erica F , Couldwell William T 
Published: January 2019

Abstract

BACKGROUND
Skull base meningioma management is complicated by their proximity to intracranial neurovascular structures because complete resection may pose a risk of worsening morbidity.

OBJECTIVE
To assess the influence of clinical outcomes and surgical management on patient-perceived quality-of-life outcomes, value, and cost-effectiveness.

METHODS
Patients who underwent resection of a skull base meningioma, had adequate clinical follow-up, and completed EQ-5D-3L questionnaires preoperatively and at 1 mo and 1 yr postoperatively were identified in a retrospective review. Cost data from the Value Driven Outcomes database were analyzed.

RESULTS
A total of 52 patients (83.0% women, mean age 51.9 yr) were categorized by worsened (n = 7), unchanged (n = 24), or improved (n = 21) EQ-5D-3L index scores at 1-mo follow-up. No difference in subcategory cost contribution or total cost was seen in the 3 groups. Patients with improved scores showed a steady improvement through each follow-up period, whereas those with unchanged or worsened scores did not. Mean quality-adjusted life years (QALYs) and cost per QALY improved for all groups but at a higher rate for patients with better outcomes at 30-d follow-up. Female sex, absence of proptosis, nonfrontotemporal approaches, no optic nerve decompression, and absence of surgical complications demonstrated improved EQ-5D-3L scores at 1-yr follow-up. A mean cost per QALY of $27 731.06 ± 22 050.58 was observed for the whole group and did not significantly differ among patient groups (P = .1)

CONCLUSION
Patients undergoing resection of skull base meningiomas and who experience an immediate improvement in EQ-5D are likely to show continued improvement at 1 yr, with improved QALY and reduced cost per QALY.
The Spectrum of Trigeminal Neuralgia Without Neurovascular Compression
Authors: Magown Philippe , Ko Andrew L , Burchiel Kim J 
Published: January 2019

Abstract

BACKGROUND
In trigeminal neuralgia type 1 (TN1), neurovascular compression (NVC) is often assumed to be the pain initiating mechanism. NVC can be surgically addressed by microvascular decompression (MVD). However, some patients with TN1 present without NVC (WONVC).

OBJECTIVE
To characterize and analyze the clinical spectrum of a TN1 patient population WONVC.

METHODS
A retrospective chart review of patients presenting with TN1 between 2007 and 2017 was performed. Patients who were potential candidates for MVD surgery underwent high-resolution imaging with 3-dimensional (3D) reconstruction to address the presence, or absence, of NVC. Demographic data about the populations with NVC (WNVC) and WONVC were collected.

RESULTS
Of 242 patients with TN1, 32% did not have NVC. Patients WONVC were on average 10.6 yr younger than those WNVC. TN1 onset in patients WONVC was more frequent below 48.7 yr, and the opposite was found in patients WNVC. Compared to patients WNVC, those WONVC were predominantly female (odds ratio 4.8), on average were 4 yr younger at symptom onset (34.7 yr) and 7.8 yr younger at first clinic visit, and had a 3.7 yr shorter symptom duration.

CONCLUSION
Patients presenting with TN1 WONVC were predominantly females in their mid-30s with short symptom duration. In the absence of NVC, this subgroup of TN1 patients has limited surgical options, and potentially a longer condition duration that must be managed medically or surgically. This population WONVC might provide insights into the true pathophysiology of TN1.
Infrared luminosity functions based on 18 mid-infrared bands: revealing cosmic star formation history with AKARI and Hyper Suprime-Cam
Authors: Goto Tomotsugu , Oi Nagisa , Utsumi Yousuke , Momose Rieko , Matsuhara Hideo , Hashimoto Tetsuya , Toba Yoshiki , Ohyama Youichi , Takagi Toshinobu , Chiang Chia-Ying , Kim Seong Jin , Kilerci Eser Ece , Malkan Matthew , Kim Helen , Miyaji Takamitsu , Im Myungshin , Nakagawa Takao , Jeong Woong-Seob , Pearson Chris , Barrufet Laia , Sedgwick Chris , Burgarella Denis , Buat Veronique , Ikeda Hiroyuki 
Published: January 2019

AbstractMuch of star formation is obscured by dust. For a complete understanding of the cosmic star formation history (CSFH), infrared (IR) census is indispensable. AKARI carried out deep mid-infrared observations using its continuous nine-band filters in the North Ecliptic Pole (NEP) field (5.4 deg2). This took a significant amount of the satellite’s lifetime, ∼10% of the entire pointed observations. By combining archival Spitzer (five bands) and WISE (four bands) mid-IR photometry, we have, in total, 18-band mid-IR photometry, which is the most comprehensive photometric coverage in the mid-IR for thousands of galaxies. However, we only had shallow optical imaging (∼25.9 AB magnitude) in a small area, 1.0 deg2. As a result, thousands of AKARI’s infrared sources remained undetected in the optical. Using the new Hyper Suprime-Cam on the Subaru telescope, we obtained deep enough optical images of the entire AKARI NEP field in five broad bands (g ∼ 27.5 mag). These provided photometric redshift, and thereby IR luminosity, for the previously undetected faint AKARI IR sources. Combined with the accurate mid-IR luminosity measurement, we constructed mid-IR luminosity functions (LFs), and thereby performed a census of dust-obscured CSFH in the entire AKARI NEP field. We have measured rest-frame 8 μm and 12 μm LFs, and estimated total infrared LFs at 0.35 &lt; $z$ &lt; 2.2. Our results are consistent with our previous work, but with much reduced statistical errors thanks to the large-area coverage of the new data. We have possibly witnessed the turnover of CSFH at $z$ ∼ 2.
Matching in Housing Markets: The Role of Ethnic Social Networks
Authors: Agarwal Sumit , Choi Hyun-Soo , He Jia , Sing Tien Foo 
Published: January 2019

Abstract
This paper investigates the role of ethnic matching between buyers and sellers in Singapore’s public housing market. We find that sellers sell homes in blocks with a high concentration of their own (other) ethnic group(s) at significant premiums (discounts). Chinese sellers earn 1.7% higher premiums when selling homes to Chinese buyers in high Chinese concentrations housing blocks, but Malay sellers accept 1.6% discounts from Malay buyers in the same blocks. We find that the high volume of within-ethnicity transactions with the price discounts is supported by the ethnic social networks, that is, through ethnicity-specialized real estate agents.
Received May 3, 2017; editorial decision July 4, 2018 by Editor Stijn Van Nieuwerburgh.
Polypharmacy is associated with treatment response and serious adverse events: results from the British Society for Rheumatology Biologics Register for Rheumatoid Arthritis
Authors: Bechman Katie , Clarke Benjamin D , Rutherford Andrew I , Yates Mark , Nikiphorou Elena , Molokhia Mariam , Norton Sam , Cope Andrew P , Hyrich Kimme L , Galloway James B 
Published: January 2019

Abstract

Objective
To evaluate whether polypharmacy is associated with treatment response and serious adverse events (SAEs) in patients with RA using data from the British Society for Rheumatology Biologics Register (BSRBR-RA).

Methods
The BSRBR-RA is a prospective observational cohort study of biologic therapy starters and a DMARD comparator arm. A logistic regression model was used to calculate the odds of a EULAR ‘good response’ after 12 months of biologic therapy by medication count. Cox proportional hazards models were used to identify risk of SAEs. The utility of the models were compared with the Rheumatic Disease Comorbidity Index using Receiver Operator Characteristic and Harrell’s C statistic.

Results
The analysis included 22 005 patients, of which 83% were initiated on biologics. Each additional medication reduced the odds of a EULAR good response by 8% [odds ratios 0.92 (95% CI 0.91, 0.93) P < 0.001] and 3% in the adjusted model [adjusted odds ratios 0.97 (95% CI 0.95, 0.98) P < 0.001]. The Receiver Operator Characteristic demonstrated significantly greater areas under the curve with the polypharmacy model than the Rheumatic Disease Comorbidity Index. There were 12 547 SAEs reported in 7286 patients. Each additional medication equated to a 13% increased risk of an SAE [hazard ratio 1.13 (95% CI 1.12, 1.13) P < 0.001] and 6% in the adjusted model [adjusted hazard ratio 1.06 (95% CI 1.05, 1.07) P < 0.001]. Predictive values for SAEs were comparable between the polypharmacy and Rheumatic Disease Comorbidity Index model.

Conclusion
Polypharmacy is a simple but valuable predictor of clinical outcomes in patients with RA. This study supports medication count as a valid measure for use in epidemiologic analyses.
Migrant and/or Care Workers? Debating the Ethnicization of the Elderly Care Market in Italy and the United Kingdom
Authors: Ranci Costanzo , Arlotti Marco , Cerea Stefania , Cordini Marta 
Published: January 2019

AbstractCare marketization has generally supported ethnicization of care work in many countries. While economic and institutional theories have explained how migrants have been included as functional workers, the social inclusion of them in the hosting societies has been largely neglected. Focusing on the role of ideas and public discourse, this article considers through a content analysis of newspaper articles how the role of migrant care workers has been the object of public discussion in two countries characterized by care marketization: Italy and the United Kingdom. It shows how ethnicized care markets have been differently legitimized through distinct social and cultural dynamics
Pathophysiological responses of pine defensive metabolites largely lack differences between pine species but vary with eliciting ophiostomatoid fungal species
Authors: Cale Jonathan A , Klutsch Jennifer G , Dykstra Christien B , Peters Brosnon , Erbilgin Nadir 
Published: January 2019

AbstractPhytopathogenic ophiostomatoid fungi are common associates of bark beetles and contribute to beetle-associated mortality of trees. Mountain pine beetle outbreaks in Canada are facilitating novel associations between its vectored fungi (Grosmannia clavigera, Leptographium longiclavatum and Ophiostoma montium) and jack pine. How the induced defense-related metabolite responses of jack and lodgepole pines vary in response to the fungi is unknown. Understanding this variation is important to clarifying pine susceptibility to and the physiological impacts of infection. We used a comparative metabolite profiling approach to investigate the defense-related signaling, carbon utilization/mobilization, and synthesis responses of both pines to the fungi. Both pine species largely exhibited similar metabolite responses to the fungi. The magnitude of pine metabolite responses positively reflected pathogen virulence. Our findings indicate that pines can recognize and metabolomically respond to novel pathogens, likely due to signals common between the novel fungi and fungi coevolved with the pine. Thus, jack pine is likely as susceptible as lodgepole pine to infections by each of the MPB-vectored fungi. Furthermore, the magnitude of the metabolite responses of both pines varied by the eliciting fungal species, with the most virulent pathogen causing the greatest reduction in carbohydrates and the highest accumulation of defensive terpenes.
Contributions of day length, temperature and individual variability on the rate and timing of leaf senescence in the common lilac Syringa vulgaris
Authors: Aikio Sami , Taulavuori Kari , Hurskainen Sonja , Taulavuori Erja , Tuomi Juha 
Published: January 2019

Abstract
Deciduous trees prepare for winter by breaking up chlorophyll and other nitrogen-rich compounds, which are resorbed for storage. Timing is important as senescence too early will waste growing season, while senescence too late risks the loss of the leaf resources to frost. While plants of temperate and boreal regions use decreasing day length as a cue of approaching winter, we show that decreasing temperature may also play a role in the variability of leaf senescence. We investigated the timing of autumnal decrease in photosynthetic efficiency and the concentration of chlorophyll and total carotenoids in nine common lilac (Syringa vulgaris L.) trees over two consecutive years. Day length explained a greater proportion of photosynthetic efficiency, but temperature had a significant additional role, which seems to be related to individual differences. Precipitation and cloudiness did not explain photosynthetic efficiency. Photosynthetic efficiency was higher outside the canopy and at high and middle elevations than inside and low elevations of the canopy. Late onset of senescence led to a steeper decline in photosynthetic efficiency than early senescence. The onset of decline in photosynthetic efficiency differed between years, but there was no difference in the steepest rate of change in photosynthetic efficiency with respect to sampling year or location. Contributions of day-length vs temperature to leaf senescence have important consequences for the adaptability and invasibility of deciduous trees in a changing climate, especially at the edge of species distributions.
A Single-Molecule Long-Read Survey of Human Transcriptomes using LoopSeq Synthetic Long Read Sequencing
Authors: Wu Indira , Ben-Yehezkel Tuval 
Published: January 2019

AbstractState-of-the-art short-read transcriptome sequencing methods employ unique molecular identifier (UMI) to accurately classify and count mRNA transcripts. A fundamental limitation of UMI-based short-read transcriptome sequencing is that each read typically covers a small fraction of the transcript sequence. Efforts to accurately characterize splicing isoforms, arguably the largest source of variation in Human gene expression, using short read sequencing have therefore largely relied on computational predictions of transcript isoforms based on indirect observations. Here we describe a transcript counting, synthetic long read method for sequencing whole transcriptomes using short read sequencing platforms and no additional hardware. The method enables full-length mRNA sequence reconstruction at single-nucleotide resolutions with high-throughput, low error rates and UMI based transcript counting using any Illumina sequencer. We describe results from whole transcriptome sequencing from total RNA extracted from 3 human tissue samples: brain, liver, and blood. Reconstructed transcript sequences are characterized and annotated using SQANTI, an analysis pipeline for assessing the sequence quality of long-read transcriptomes. Our results demonstrate that LoopSeq synthetic long-read sequencing can reconstruct contigs up to 3,900nt full-length transcripts using tissue extracted RNA, as well as identify novel splice variants of known junction donors and acceptors.
Inference and analysis of population-specific fine-scale recombination maps across 26 diverse human populations
Authors: Spence Jeffrey P. , Song Yun S. 
Published: January 2019

AbstractFine-scale rates of meiotic recombination vary by several orders of magnitude across the genome, and are known to differ between species and even between populations. Studying the differences in recombination maps across populations has been stymied by the confounding effect of differences in demographic history. To address this problem, we developed a method that infers fine-scale recombination rates while taking demography into account and applied our method to infer population-specific recombination maps for each of 26 diverse human populations. These maps recapitulate many aspects of the history of these populations including signatures of the trans-Atlantic slave trade and the Iberian colonization of the Americas. We also investigated modulators of the local recombination rate, finding an unexpected role for Polycomb-group proteins and the tri-methylation of H3K27 in elevating recombination rates. Further differences in the recombination landscape across the genome and between populations are driven by variation in the gene that encodes the DNA-binding protein PRDM9, and we quantify the weak effect of meiotic drive acting to remove its binding sites.
catch22: CAnonical Time-series CHaracteristics selected through highly comparative time-series analysis
Authors: Lubba Carl H , Sethi Sarab S , Knaute Philip , Schultz Simon R , Fulcher Ben D , Jones Nick S 
Published: January 2019

AbstractCapturing the dynamical properties of time series concisely as interpretable feature vectors can enable efficient clustering and classification for time-series applications across science and industry. Selecting an appropriate feature-based representation of time series for a given application can be achieved through systematic comparison across a comprehensive time-series feature library, such as those in the hctsa toolbox. However, this approach is computationally expensive and involves evaluating many similar features, limiting the widespread adoption of feature-based representations of time series for real-world applications. In this work, we introduce a method to infer small sets of time-series features that (i) exhibit strong classification performance across a given collection of time-series problems, and (ii) are minimally redundant. Applying our method to a set of 93 time-series classification datasets (containing over 147 000 time series, including biomedical datasets) and using a filtered version of the hctsa feature library (4791 features), we introduce a generically useful set of 22 CAnonical Time-series CHaracteristics, catch22. This dimensionality reduction, from 4791 to 22, is associated with an approximately 1000-fold reduction in computation time and near linear scaling with time-series length, despite an average reduction in classification accuracy of just 7%. catch22 captures a diverse and interpretable signature of time series in terms of their properties, including linear and non-linear autocorrelation, successive differences, value distributions and outliers, and fluctuation scaling properties. We provide an efficient implementation of catch22, accessible from many programming environments, that facilitates feature-based time-series analysis for scientific, industrial, financial and medical applications using a common language of interpretable time-series properties.
A Plant Protein NbP3IP Induces Autophagy and Mediates the Autophagic Degradation of RSV p3 to Inhibit Viral Infection
Authors: Jiang Liangliang , Lu Yuwen , Zheng Xiyin , Yang Xue , Chen Ying , Zhang Tianhao , Zhao Xing , Wang Shu , Zhao Xia , Song Xijiao , Zhang Xiangxiang , Peng Jiejun , Zheng Hongying , Lin Lin , MacFarlane Stuart , Chen Jianping , Liu Yule , Yan Fei 
Published: January 2019

ABSTRACTIn plants, autophagy is involved in responses to viral infection. However, understanding of new host factors mediating autophagic clearance of plant viruses is very limited. We here identified a new host factor NbP3IP participating in autophagy-mediated plant defense against viral infection. NbP3IP interacted with p3, a RNA silencing suppressor encoded by Rice stripe virus (RSV), a negative-strand RNA virus, and mediated its autophagic degradation. NbP3IP could also interact with NbATG8f, which was required for NbP3IP-miediated p3 degradation. Overexpression of NbP3IP induced autophagy and down-regulation of NbP3IP reduced autophagy. Both overexpression of NbP3IP and silencing of GAPC, which also induces autophagy, inhibited RSV infection. In contrast, silencing of ATG7 promoted RSV infection. Thus, through identification of a new potential selective autophagy receptor P3IP, we revealed a new mechanism of autophagy-mediated plant defense against plant viruses and provided the first evidence that plant autophagy can also play an antiviral role against negative-strand RNA viruses.
Visual imagery and visual perception induce similar changes in occipital slow waves of sleep
Authors: Bernardi Giulio , Betta Monica , Cataldi Jacinthe , Leo Andrea , Haba-Rubio José , Heinzer Raphael , Cirelli Chiara , Tononi Giulio , Pietrini Pietro , Ricciardi Emiliano , Siclari Francesca 
Published: January 2019

AbstractPrevious studies have shown that regional slow wave activity (SWA) during NREM-sleep is modulated by prior experience and learning. While this effect has been convincingly demonstrated for the sensorimotor domain, attempts to extend these findings to the visual system have provided mixed results. Here we asked whether depriving subjects of external visual stimuli during daytime would lead to regional changes in slow waves during sleep and whether the degree of ‘internal visual stimulation’ (spontaneous imagery) would influence such changes. In two 8h-long sessions spaced one-week apart, twelve healthy volunteers either were blindfolded while listening to audiobooks or watched movies (control condition), after which their sleep was recorded with high-density EEG. We found that during NREM-sleep the number of small, local slow waves in the occipital cortex decreased after listening with blindfolding relative to movie watching in a way that depended on the degree of visual imagery subjects reported during blindfolding: subjects with low visual imagery showed a significant reduction of occipital sleep slow waves, while those who reported a high degree of visual imagery did not. We also found a positive relationship between the reliance on visual imagery during blindfolding and audiobook listening and the degree of correlation in sleep SWA between visual areas and language-related areas. These preliminary results demonstrate that short-term alterations in visual experience may trigger slow wave changes in cortical visual areas. Furthermore, they suggest that plasticity-related EEG changes during sleep may reflect externally induced (‘bottom-up’) visual experiences, as well as internally generated (‘top-down’) processes.
Prevalence of near-death experiences and REM sleep intrusion in 1034 adults from 35 countries
Authors: Kondziella Daniel , Harboe Olsen Markus 
Published: January 2019

ABSTRACTBackgroundNear-death experiences have fascinated humans for centuries, but their origin and prevalence remain unknown.MethodsUsing an online crowdsourcing platform, we recruited 1034 lay people from 35 countries to investigate the prevalence of near-death experiences and self-reported REM sleep intrusion. Reports were validated using the Greyson Near-Death Experiences Scale (GNDES) with a score of ≥7 as cut-off point for identifying near-death experiences.ResultsNear-death experiences were reported by 106 of 1034 participants (10%; CI 95% 8.5-12%). REM sleep intrusion was more common in people with near-death experiences (n=50/106; 47%) than in people with experiences with 6 points or less on the GNDES (n=47/183; 26%) or in those without any such experience (n=107/744; 14%; p=<0.0001). Following multivariate regression analysis to adjust for age, gender, place of origin, employment status and perceived danger, this association remained highly significant; people with REM sleep intrusion were more likely to exhibit near-death experiences than those without REM sleep abnormalities (odds ratio 2.85; CI 95% 1.68-4.88; p=0.0001).ConclusionsThe prevalence of near-death experiences in the public is around 10%. While age, gender, place of residence, employment status and perceived threat do not seem to influence the prevalence of near-death experiences, there is a significant association with REM sleep intrusion. This finding is in line with the view that despite imminent threat to life, brain physiology must be well-preserved to perceive these fascinating experiences and store them as long-term memories.