bluuebunny/crossref_metadata_2025_split huggingface dataset:
Diabetes and Auditory-Vestibular Pathology
Authors: Elangovan Saravanan , Spankovich Christopher 
Published: October 2019

AbstractThe relationship between diabetes mellitus (DM) and the auditory/vestibular system has been investigated for more than a century. Most population-based investigations of hearing loss in persons with diabetes (PWD) have revealed a slow progressive, bilateral, high-frequency sensorineural hearing loss. Despite the growing research literature on the pathophysiology of DM-related hearing loss using various animal models and other human studies, knowledge of specific mechanism of the degenerative changes of the inner ear and/or auditory nerve is far from full elucidation. Recent investigations of the mechanisms underlying the association between hearing loss and DM suggest complex combined contributions of hyperglycemia, oxidative stress resulting in cochlear microangiopathy, and auditory neuropathy. An even lesser understood complication of DM is the effect on the vestibular system. Here we provide an overview of animal and human evidence of pathophysiological changes created by DM and its effects on auditory-vestibular anatomy and function.
Evaluation and Management of Patients with Diabetes and Hearing Loss
Authors: Spankovich Christopher , Yerraguntla Krishna 
Published: October 2019

AbstractDiabetes mellitus is a significant risk factor for acquired hearing loss and tinnitus. Persons with diabetes (PWD) may present with hearing loss symptoms earlier in life than those without diabetes. Furthermore, diabetes may exacerbate risk for hearing loss related to noise exposure and ototoxic drugs. The purpose of this article is to provide recommendations for the prevention, screening, evaluation, and management of hearing loss in PWD.
Auditory and Vestibular Side Effects of FDA-Approved Drugs for Diabetes
Authors: DiSogra Robert M. , Meece Jerry 
Published: October 2019

AbstractAs of September 10, 2019, there were 75 medications (oral/injectable/inhalants) approved by the U.S. Food and Drug Administration for diabetes management: 1 inhalant, 21 oral combinations, 22 injectable, and 31 oral medications (not in combination with any other diabetes drug). This article isolates the auditory and vestibular side effects of those drugs as reported by the drug's manufacturer as well as those side effects that could interfere with a balance assessment. Twenty of the 75 approved medications (26%) could have an auditory-related side effect. Hearing loss and tinnitus are not on the list. Only two, or just 3%, have vertigo and spinning as reported side effects (one each). More than 50% of the drugs will have some effect on a balance assessment. Audiologists who evaluate a patient with diabetes (PWD) are presented with symptoms that could be related to their diabetes medication. Although the manufacturer might report a side effect as rare or as a percentage from their clinical trials subjects, not all PWD will experience these adverse events. Auditory and vestibular side effects do not dominate the diabetes drug side effect list, but, rather, the most reported side effects could impact a balance assessment. The lists that appear in Appendices A and B should serve as a guide for all professionals involved in managing the PWD (i.e., audiologists, otolaryngologists, diabetes educators, pharmacists, optometrists, dentists, etc.). The list also serves as a counseling tool if a communication problem emerges during the progression of the diabetes.
Eating Epilepsy: Pathophysiologic Models, Electroclinical Phenotypes, and Outcome
Authors: Iodice Alessandro 
Published: October 2019

AbstractEating epilepsy (EE) is a rare form of reflex epilepsy precipitated by food. Ictal semiology may vary depending on the etiology, age at onset, and cerebral areas involved in the epileptogenic network. In childhood, EE could manifest as tonic head drop seizures, generalized seizures, or late-onset epileptic spasms. However, in teenagers or adults, seizures are often preceded by aura and commonly manifest as focal seizures with or without impaired awareness. Brain magnetic resonance imaging abnormalities are seen in less than half of the reported cases. Posterior or multifocal interictal discharges can be seen in patients with EE. No randomized data about treatment are available. Structural epilepsies or coexistent unprovoked seizures other than eating seizures are poor prognostic factors for pharmacological outcome.
Effect of Pregabalin on Perioperative Headache in Patients with Aneurysmal Subarachnoid Hemorrhage: A Randomized Double-Blind, Placebo-Controlled Trial
Authors: Lionel Karen Ruby , Sethuraman Manikandan , Abraham Mathew , Vimala Smita , Prathapadas Unnikrishnan , Hrishi Ajay Prasad 
Published: October 2019

Abstract
Background Patients with acute aneurysmal subarachnoid hemorrhage (aSAH) experience excruciating headache that is difficult to manage in resource-constrained settings. Pregabalin’s (β-isobutyl-GABA) analgesic, antiepileptic, and antiemetic properties make it an attractive adjuvant in pain management for these patients.
Methods We conducted a double-blind, placebo-controlled, randomized clinical trial on 40 aSAH patients undergoing aneurysmal clipping to assess the effect of perioperative pregabalin in decreasing perioperative headache, anesthetic, and opioid requirement. Patients received either pregabalin (75 mg) or placebo twice daily soon after admission till 24-hour postoperative, in addition to paracetamol 650 mg thrice daily. Headache assessed using a visual analog scale (VAS) at five time points was compared using a mixed effects regression model.
Results Pain assessed by VAS declined significantly more from the baseline in pregabalin recipients compared with placebo at preinduction (–3.6 vs.–1.8; p = 0.004), 12-hour (4.3 vs. 2.8; p = 0.014), and 24-hour postsurgery (4.7 vs. 2.9; p = 0.007), but not at the 6-hour postoperation (4.9 vs. 3.8; p = 0.065). Pregabalin recipients required a lower minimum alveolar concentration of sevoflurane to maintain a prespecified bispectral index of 40 and 60 (0.8 vs. 0.9; p = 0.014) and required fewer rescue analgesic doses in the 24 hours following surgery (1.8 vs. 3.3; p = 0.005). The intraoperative fentanyl requirement was not significantly different between the groups (10 μg/kg vs. 11.4 μg/kg; p = 0.065). There was no significant difference in the sedation scores.
Conclusions Pregabalin 75 mg administered twice daily, during the perioperative period, was an effective adjunct in the management of the severe headache experienced by patients with aSAH and decreased the opioid and anesthetic requirement without significantly increasing sedation.
Encondromas da mão: Uma experiência de 20 anos
Authors: Sollaci Claudio , Araújo Gabriel Costa Serrão de 
Published: October 2019

Resumo
Objetivo Os encondromas são os tumores mais comuns dos ossos da mão, com uma grande variedade de abordagens terapêuticas. O presente artigo apresenta as características dos tumores, métodos diagnósticos e tratamentos.
Métodos Discutimos a abordagem da nossa instituição, onde tratamos 48 pacientes com encondromas da mão, entre 1996 e 2016. Nossa técnica de tratamento, que permanece a mesma ao longo de duas décadas, compreende o uso de curetagem, esmeril de velocidade e enxerto ósseo autólogo (retirado com uma técnica minimamente invasiva, usando uma agulha de Craig).
Resultados A dor e as fraturas foram os sintomas mais comuns, levando os pacientes à consulta, nas frequências de 33,3% e 31,3%, respectivamente. Um total de 27,1% dos casos era assintomático, e suas lesões foram descobertas incidentalmente. A média de idade foi de 34,4 anos (desvio padrão [DP] = 12,9 anos). Os tumores foram mais frequentemente encontrados no lado ulnar da mão, no quinto raio (41,5%), e nos ossos proximais (nas falanges proximais [43,8%] e no metacarpo [33,3%]). O tamanho do tumor variou de 0,2 cm2 a 5,7 cm2, com média de 1,7 cm2 (DP = 1,0 cm2) e não foi associado à fratura (p = 0,291). A fratura também não foi associada a nenhum dos sintomas, e nem à idade dos pacientes (p = 0,964). Após o tratamento, a maioria dos pacientes alcançou amplitude completa de movimento (91,7%), com boa integração do enxerto ósseo. Três pacientes apresentaram déficit no arco de movimento (6,3%) e a incidência de complicações também foi de 6,3% (3 pacientes). No final, após as revisões cirúrgicas necessárias, esses três pacientes também recuperaram a função completa. Eles tiveram a integração total do enxerto ósseo, recuperaram toda a amplitude de movimento e retornaram ao trabalho. Não houve nenhum caso de recorrência do tumor durante o período de acompanhamento avaliado. Em nenhum dos casos ocorreram complicações no local doador.
Conclusão O nosso método de tratamento forneceu consistentemente bons resultados, com apenas algumas complicações menores. Nível terapêutico de evidência: IV.
Bipartite nonlocality with a many-body system
Authors: Oudot Enky , Bancal Jean-Daniel , Sekatski Pavel , Sangouard Nicolas 
Published: October 2019

Abstract
We consider a bipartite scenario where two parties hold ensembles of 1/2-spins which can only be measured collectively. We give numerical arguments supporting the conjecture that in this scenario no Bell inequality can be violated for arbitrary numbers of spins if only first order moment observables are available. We then give a recipe to achieve a significant Bell violation with a split many-body system when this restriction is lifted. This highlights the strong requirements needed to detect bipartite quantum correlations in many-body systems device-independently.
A tunneling current measurement scheme to observe Majorana-zero-mode-induced crossed Andreev reflection
Authors: Fang Lei , Schmeltzer David , Zhu Jian-Xin , Saxena Avadh 
Published: October 2019

Abstract
We propose a scheme to observe the Majorana-zero-mode-induced crossed Andreev reflection by measuring tunneling current directly. In this scheme a metallic ring structure is utilized to separate electron and hole signals. Since tunneling electrons and holes have different propagating wave vectors, the conditions for them to be constructively coherent in the ring differ. We find that when the magnetic flux threading the ring varies, it is possible to observe adjacent positive and negative tunneling current peaks of about equal amplitudes.
Quantifying the interplay between genetic and epigenetic regulations in stem cell development
Authors: Zhang Yunbin , Liu Ning , Lin Wei , Li Chunhe 
Published: October 2019

Abstract
Waddington epigenetic landscape, as a classic metaphor, has been used to explain cellular development and differentiation. However, it remains challenging to quantify the epigenetic landscape. Especially, a key issue arises as what are the underlying mechanisms for the interplay between genetic and epigenetic regulations to govern cell fate decisions in development. Based on a developmental epigenetic model combining histone modifications and gene regulations, we studied state switching mechanisms of histone modifications for stem cell development, and uncovered corresponding epigenetic landscape. The topography of landscape provides a quantitative measure for the relative stability of different attractors or phenotypes. We showed that histone regulations facilitate the occurrence of intermediate states or multistability. From the epigenetic landscape of stem cell differentiation, we identified key cellular states characterized by attractors, including pluripotent stem cell state, differentiated state and intermediate states. We also quantified representative kinetic transition paths for differentiation, reprogramming and transdifferentiation, which agree well with previous experimental observations. Specifically, previous experiments indicate that transdifferentiation can go through a mixed, unspecific intermediate or progenitor-like state. By calculating the kinetic transition paths, our developmental epigenetic models are able to replicate all these three experimental results, and therefore provide theoretical explanations for these experimental observations. We propose that epigenetic regulations play critical roles on the kinetic transitions for differentiation, reprogramming and transdifferentiation, which also provide a source for the heterogeneity of gene expressions observed in developmental process. Our work provides new insights into the roles of epigenetic modifications on controlling gene expression and stem cell differentiation, and facilitates our mechanistic understanding for the cell fate determinations regarding the interplay between genetic and epigenetic regulations.
Probing relaxations of atomic-scale junctions in the Pauli repulsion range
Authors: Brand J , Néel N , Kröger J 
Published: October 2019

Abstract
Clean metal as well as C60-terminated tips of an atomic force microscope probe the interaction with C60 molecules adsorbed on Cu(111) and Pb(111). The force measurements unveil a monotonic shift of the point of maximum attraction with the bias voltage. The conventional superposition of long-range van der Waals and electrostatic forces with short-range Pauli repulsion does not reproduce the shift. By phenomenologically including bias-dependent relaxations of the electrode geometry in the analytical expression for the short-range force the experimental data can qualitatively be described.
Comparing the dynamics of periodically forced lasers and neurons
Authors: Tiana-Alsina Jordi , Quintero-Quiroz Carlos , Masoller Cristina 
Published: October 2019

Abstract
Neuromorphic photonics is a new paradigm for ultra-fast neuro-inspired optical computing that can revolutionize information processing and artificial intelligence systems. To implement practical photonic neural networks is crucial to identify low-cost energy-efficient laser systems that can mimic neuronal activity. Here we study experimentally the spiking dynamics of a semiconductor laser with optical feedback under periodic modulation of the pump current, and compare with the dynamics of a neuron that is simulated with the stochastic FitzHugh–Nagumo model, with an applied periodic signal whose waveform is the same as that used to modulate the laser current. Sinusoidal and pulse-down waveforms are tested. We find that the laser response and the neuronal response to the periodic forcing, quantified in terms of the variation of the spike rate with the amplitude and with the frequency of the forcing signal, is qualitatively similar. We also compare the laser and neuron dynamics using symbolic time series analysis. The characterization of the statistical properties of the relative timing of the spikes in terms of ordinal patterns unveils similarities, and also some differences. Our results indicate that semiconductor lasers with optical feedback can be used as low-cost, energy-efficient photonic neurons, the building blocks of all-optical signal processing systems; however, the length of the external cavity prevents optical feedback on the chip.
A new Lagrange-Galerkin scheme for solving fluid flow in porous media
Authors: Wijaya Imam , Kimura Masato , Notsu Hirofumi 
Published: October 2019

Abstract
We introduce a new Lagrange–Galerkin scheme for computing fluid flow through porous media. The method of volume averaging of the velocity and pressure deviation in the pore is employed to derive the macroscopic mass and momentum conservation in the porous medium in which this technique was established by Hsu and Cheng. We derive the Lagrange–Galerkin scheme by extending the idea of the method of characteristics to overcome the difficulty which comes from the non-homogeneous porosity. The numerical experiment are conducted to verify the performance of the new numerical scheme. The new numerical scheme shows a good agreement with the analytical solution and has 2
nd
order accuracy both in space and time.
3d seismic velocity structure imaging beneath Flores region using local earthquake tomography
Authors: Maneno R , Santosa B J 
Published: October 2019

Abstract
Flores is one of the seismically high activity zones of Indonesia region as a consequence of Indo-Australian plate subduction under the Eurasian plate. We investigate 3D seismic velocity structure beneath Flores region and the surrounding area as an effort to understand earthquake source mechanisms and subsurface geometry for the purpose of earthquake disaster mitigation. The study based on travel-time tomography using 223 earthquakes provided by webdc.eu catalog data which is recorded by up to 4 stations during period from January 2010 to March 2018. In the early data processing stages, a total of 1763 P-wave arrivals and 1763 S-wave arrivals were manually picked from 15 seismic stations around the Flores region using SeisGram2k70. 170 events with minumum error in VELEST used to derive a minimum 1D velocity model. The combination of Santosa & Haslinger and AK135 velocity model used as a reference velocity model to Flores region. Futhermore we applied Local Earthquake Tomography (LOTOS 12) to investigated 3D seismic velocity in order to describe anomalous distribution of P and S wave velocities beneath Flores Region. The results showed that Flores region is dominated by a negative seismic velocity anomaly and a high Vp / Vs ratio that is thought to be related to the fault area due to the Flores Thrust Zone in the north and west of Flores and the upward fault in east Flores. The southern part of Flores is dominated by positive anomalies and a low Vp / Vs ratio which is thought to be igneous and metamorphic layers with a low liquid saturation level. Insufficient data causes the resulting tomographic resolution to be poor.
First light curve analysis of eclipsing binary system ASAS 185542–0123.1
Authors: Jatmiko Agus T P , Yusuf M , Putra M 
Published: October 2019

Abstract
A very first light curve (LC) analysis of eclipsing binary ASAS 185542–0123.1 is presented. This star is part of our binary star survey project at Bosscha Observatory and also plays an important role as a testing ground for our new robotic telescope. LC of this star was constructed by using LEMON, a semi–automatic photometric pipeline written in Python. We managed to refine orbital period of this system and its time of primary minimum, hence we could update its ephemeris as Min I(HJD) = 2451964.551517 + 1.161607 × E. We also conducted a LC modeling with PHOEBE (PHysics Of Eclipsing BinariEs) software built on top of the widely used WD program. The photometry solutions are mass ratio q = 0.309 ± 0.026, orbital inclination i = 83.15 ± 0.42°, ratio of effective temperatures

T
2

T
1

=
0.972
±
0.008

, and surface potentials for primary and secondary component Ω1 = 4.08 ± 0.16 and Ω2 = 2.71 ± 0.10, respectively. In conclusion, this system is classified as detached eclipsing binary system which has almost similar temperatures between its primary and secondary component. From temperature solution estimation, we have preliminary conclusion that its primary and secondary component has a spectral type of G0/1V + G2/3V, respectively.
Tracing Stellar Close Encounters with Our Sun from GAIA DR2, LAMOST DR4, and RAVE DR5 Catalogues
Authors: Darma R , Hidayat W , Arifyanto M I 
Published: October 2019

Abstract
Our Sun is surrounded by the Oort Cloud (in radius 0.5 pc) which can be perturbed by various external factors. One of those is the stellar close encounter with our Sun. This kind of perturbation can induce the cometary showers in our Solar System. In this work, we attempt to make numerical simulations to trace the orbit of stars which close encounter with our Sun in the cases of Milky Way’s axisymmetric only and with non-axisymmetric potentials. We have 306 selected solar neighborhood stars from GAIA DR2, LAMOST DR4, and RAVE DR5 which have highly precise kinematics.
In this work, we find a few stars that have counter parameter (dm
) less than or equal to 2 pc in both of past and future close encounters with the Sun. We also find a few stars (ID 283, 290, 297, 298) even with dm
≤ 0.5 pc within their errors, for past close encounters at time tm
≥ 0.5 Myr ago. These stars should have perturbed the Oort Cloud’s stability long time ago. Furthermore, we find a few stars (ID 293, 299, 300) with dm
≤ 1 pc within their errors, at tm
> 0.6 Myr for future close encounters. Besides that,cadding non-axisymmetric component of Milky Way does not change the results. This suggests that the non-axisymmetric component of Milky Way potential has small effect in perturbing the orbital motion of stars for short timescale. That’s why the values of dm
are relatively similar within their errors, for both cases of the Milky Way potential.
Metals Content In Edible Gastropod From Blanakan Silvofishery Ponds
Authors: Artalina Desmita , Takarina Noverita Dian 
Published: October 2019

AbstractHuman activities contribute to waste and promote threats to water quality. Heavy metals contamination is one of the threats. High input of heavy metals on ponds will affect organism including gastropods. Mangrove snail (Telescopium telescopium) is one of the non-cultural biotas which is consumed by humans. This research aimed to determine metals content in mangrove snail flesh from Blanakan silvofishery ponds. Samples were conducted from three ponds using a purposive sampling technique in April 2018. Metals content were analyzed using Atomic Absorption Spectrophotometry. The Result showed that the highest Pb and Cu content was in pond 3 at 19,46 mg/kg and 27,52 mg/kg respectively and the highest Zn content was in pond 1 at 21,28 mg/kg. The Bioconcentration Factor (BCF) values ranged 0,05 – 4,57 showed that mangrove snail has a tendency to accumulate heavy metals. The bioconcentration values > 1 at Cu showed that mangrove snail can be used as bioindicator to control Cu pollution, especially in the mangrove ecosystem. One of the efforts to protect public health is to set a maximum limit of metal contamination in food that is suitable for consumption. The maximum limit of metal contamination in food is determined through a decree of the General Director of Drug and Food Control, an institution in Indonesia which is in charge of overseeing the circulation of drugs and food in accordance with the provisions of the legislation. Based on The National Agency of Drug and Food Control No. 03725/B/SK/VII/89, people must be more careful in consuming mangrove snail.
Chaotic Behaviour of Modified Hamiltonian Peyrard-Bishop-Dauxois Model on DNA System
Authors: Sutantyo Trengginas E P , Dwiputra D , Hidayat W , Zen Freddy P 
Published: October 2019

Abstract
DNA research has involved a variety of disciplines across fields, which work complementary and supportive by using the theory, model, and experiment. Physics provides a theoretical basis that can be used for experimentation, as well as developing new physical models. This physical model can explain the nonlinear dynamics of DNA. In this study, we modified Hamiltonian Peyrard-Bishop-Dauxois (PBD) model by adding the influence of the surrounding environment namely thermal bath, in the form of time-dependent thermal friction and stochastic white noise. Both are represented through the Nosé-Hoover-Langevin (NHL) thermostat. Formulations of equation motion are obtained using analytical methods, to be solved using numerical methods. We present the numerical calculations results in phase space images to show chaotic behaviour. Furthermore, we gain an increase in chaotic patterns along with the increase in temperature. In addition, we also obtain the relationship between the distance of the base pair with temperature, especially in the denaturation process.