bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinico-Epidemiological Study of Morphological Patterns of Allergic Contact Dermatitis due to Lac Bangles in Females of Hadoti Region
Authors: Sharma Neha , Kumar Ramesh , Yadav Devendra , Nyati Asha , Jain Suresh Kumar , Panwar Apoorva 
Published: November 2024

Abstract

Background:
India is a country with diverse religious and cultural practices instigating skin diseases which may be missed due to lack of awareness. Contact dermatitis (CD) to lac is not uncommon yet an underreported entity.

Objectives:
To study clinical patterns of allergic CD due to lac bangles and to assess common contact allergens.

Methodology:
A retrospective study was conducted after approval by an ethical committee. Out of 850 patients attending the CD clinic from January 2021 to December 2022, the prevalence of CD lac bangles was 40 (4.7%). After obtaining consent, the history of sites, duration, morphology, and DLQI were recorded from patients’ medical records. Patch testing with Indian standard series (ISS) and raw lac powder mixed with control was done.

Results:
A total of 40 females were evaluated. The mean duration between contact and first symptom was 14.8 ± 10.43 months. Morphology was dry eczematous in 18 (45%), lichenoid in 10 (25%), oozy eczematous in 5 (12.5%), urticarial in 5 (12.5%) and vesiculobullous in 2 (5%) patients. In 14 (35%) females, lesions were disseminated. In 12 (30%) females, CD to bindi (4), lipstick (1), Sindhoor (5), rings (1), and plastic slippers (1) were associated. The mean DLQI was 19.37 ± 3.4. Patch test results were positive with ISS allergen epoxy in 9 (22.5%) patients, nickel in 6 (15%), cobalt in 6 (15%), paraphenylenediamine in 5 (12.5%), and lac in only 2 (5%) patients.

Conclusion:
Data observed in the present study suggests that CD to lac is a distinct clinical entity. Low positivity with lac in patch test proposes the need for standardized testing material.
Shedding New Light on Cutaneous Horns: A Comprehensive Review and Pitfall of Management
Authors: Wan Leo , Park Aileen , Arastu Kamran , Khachemoune Amor 
Published: November 2024

Abstract
A cutaneous horn, also known as cornu cutaneum, is an uncommon protuberance of highly compacted keratinous material from the stratum corneum, resembling an animal horn. Although the cause and pathogenesis of these lesions were long misunderstood, cutaneous horns are now generally recognised to be reactive skin growths that can result from a variety of infectious, malignant, pre-malignant, and benign conditions. Most cutaneous horns are benign, but approximately 16%–20% are malignant, with squamous cell carcinoma being the most common malignant underlying aetiology. As the identification of the underlying aetiology necessitates microscopic examination of the base of the cutaneous horn, a major potential pitfall in the diagnosis and management of these lesions lies in the use of improper biopsy technique, which leads to inadequate sampling and failure to correctly identify the underlying aetiology of the lesion. This focused and up-to-date comprehensive review addresses the clinical presentations, epidemiology, aetiology/pathogenesis, histopathology, and differential diagnosis for cutaneous horns. In addition, we provide an overview of the many conditions that may underlie cutaneous horns and the management/treatment of cutaneous horns, including a discussion of proper excision/biopsy technique. Our review aims to enhance understanding and shed light on some of the potential pitfalls in the diagnosis and treatment of cutaneous horns, with the goal of improving outcomes for patients presenting with this condition.
Evaluation of Dose Calculation Algorithms Accuracy for ISOgray Treatment Planning System in Motorized Wedged Treatment Fields
Authors: Raghavi Sajjad , Sadoughi Hamid-Reza , Ravari Mohammad Ehsan , Behmadi Marziyeh 
Published: November 2024

Abstract

Background:
Different dose calculation methods vary in accuracy and speed. While most methods sacrifice precision for efficiency Monte Carlo (MC) simulation offers high accuracy but slower calculation. ISOgray treatment planning system (TPS) uses Clarkson, collapsed cone convolution (CCC), and fast Fourier transform (FFT) algorithms for dose distribution. This study’s primary goal is to evaluate the dose calculation accuracy for ISOgray TPS algorithms in the presence of a wedge.

Methods:
This study evaluates the dose calculation algorithms using the ISOgray TPS in the context of radiation therapy. The authors compare ISOgray TPS algorithms on an Elekta Compact LINAC through MC simulations. The study compares MC simulations for open and wedge fields with ISOgray algorithms by using gamma index analysis for validation.

Results:
The percentage depth dose results for all open and wedge fields showed a more than 98% pass rate for points. However, there were differences in the dose profile gamma index results. Open fields passed the gamma index analysis in the in-plane direction, but not all points passed in the cross-plane direction. Wedge fields passed in the cross-plane direction, but not all in the in-plane direction, except for the Clarkson algorithms.

Conclusion:
In all investigated algorithms, error increases in the penumbra areas, outside the field, and at cross-plane of open fields and in-plane direction of wedged fields. By increasing the wedge angle, the discrepancy between the TPS algorithms and MC simulations becomes more pronounced. This discrepancy is attributed to the increased presence of scattered photons and the variation in the delivered dose within the wedge field, consequently impacts the beam quality. While the CCC and FFT algorithms had better accuracy, the Clarkson algorithm, particularly at larger effective wedge angles, exhibited greater effectiveness than the two mentioned algorithms.
Vaidyakulguru Mahakavi Shri Krishnaram Bhatta (1849–1898): A great versifier of Ayurveda therapeutics
Authors: Kumari Monika , Vedi Shashi Kant , Meena Bani Ram 
Published: November 2024

Abstract
Much of the traditional knowledge related to Ayurveda remains with ancient physicians. Born into a distinguished lineage of royal physicians in Jaipur, Rajasthan, Vaidyakulguru Mahakavi Shri Krishnaram Bhatt was an eminent figure of nineteenth-century India, who excelled in both Ayurveda and literature. His lineage boasted of a rich tradition of Ayurvedic practice, which he carried forward with his intellectual expertise and poetic talent. The information related to his personality and his biography has been compiled with the help of the books written by him, texts written by other authors, and by conducting direct interviews with his family members for this article. Apart from being a prominent scholar of Ayurveda, its medicinal preparations, and its uses, he was also an expert in Sanskrit literature, poetry, and prosody. His educational journey under the guidance of eminent scholars earned him recognition as a polymath. His seminal work, “Siddha-Bheshajamanimala,” is a comprehensive guide to Ayurvedic formulations, reflecting his clinical acumen and poetic prowess. Apart from this, Kachchvansh Mahakavya, Sara-Shatakam, Jaipur-Vilas, Aryalankar-Shatakam, and other works are also among his important works. Despite his untimely demise, the legacy of Shri Krishnaram Bhatt continues to enrich the tradition of Ayurveda through his descendants. His life embodies a harmonious blend of Ayurvedic knowledge and literary excellence, leaving an indelible mark on India’s cultural and intellectual landscape and inspiring future generations of Ayurvedic practitioners.
Prabhakar Joshi Nana- Vaidya who revolutionized affordable panchakarma treatments
Authors: Tavhare Swagata Dilip , Joshi Chinmayee Pravin , Sawant Prajakta Dhairyashil , Lingayat Amit C. 
Published: November 2024

Abstract
Vaidya Prabhakar Tanaji Joshi is well known in Ayurvedic circles as Nana. He was a well-known Ayurvedic physician for his ability to treat patients with Panchakarma (five internal bio-cleansing therapies) at a reasonable cost. He was also a social leader who cared for the wellbeing of his community and treated emergency cases with Panchakarma. Since the 1960s, he has devoted his life to practicing, teaching, raising awareness, and promoting acceptance of Ayurveda. He had successfully treated a great deal of cases of measles, chikungunya, infertility, skin illnesses, and even tuberculosis without the need for an anti-tubercular regimen. He had also prevented hysterectomy in several women who had been recommended. He inspired people to cultivate therapeutic plants and established a pharmacy where he could manufacture medicines at low cost. He had written numerous scholarly publications and chaired numerous scientific sessions. He mentored and instructed numerous accomplished Ayurvedic practitioners. Through immense diligence, self-control, empathy, and genuineness, he dedicated his life to advancing the field of Ayurveda.
Integrating Traditions: Dr. Janki Nath Hakim’s Impact on Ayurveda and Unani Medicine in India
Authors: Ratha Kshirod Kumar , Meda Mruthyumjaya Rao 
Published: November 2024

Abstract
Dr. Janki Nath Hakim (1913–1985) was a prominent figure in the development of Ayurveda and Unani medicine in India, leaving a significant legacy within the traditional healthcare and educational sectors. Born into a family of esteemed Unani practitioners in Srinagar, Jammu, and Kashmir, Dr. Hakim earned a B.Sc. and an A.M.S. degree from Banaras Hindu University, fostering a foundation that would enable him to bridge both Ayurveda and Unani systems. Throughout his career, he held influential leadership positions, notably as Principal of Gopabandhu Ayurveda Mahavidyalaya in Odisha and the Unani and Tibbia College in Srinagar, where he introduced innovative educational programs. His accomplishments include instituting the BAMS curriculum, launching a postgraduate course in Kayachikitsa at Gopabandhu Ayurveda Mahavidyalaya, and advancing the institutional presence of Unani and Ayurveda education. Dr. Hakim was also a strong advocate for equal professional recognition for traditional medicine practitioners within Jammu and Kashmir, successfully working to achieve parity with allopathic systems. His legacy, carried forward by his family’s continued involvement in traditional medicine, remains a source of inspiration, contributing to the integration and broader acceptance of Ayurveda and Unani practices within India’s healthcare framework.
Kabiraj Laxman Mishra: A pioneer of Ayurveda and social welfare in Odisha
Authors: Priyadarshinee Otta Susmita 
Published: November 2024

Abstract
Kabiraj Laxman Mishra, a prominent figure in the field of Ayurveda in Odisha, India, dedicated his life to serving patients from low socio-economic backgrounds throughout the region. Born in January 1900 into a Brahmin family, he received his foundational education at Satyabadi Vana Vidyalaya, renowned for its emphasis on moral values and formal learning. He subsequently graduated from Ravenshaw College in Cuttack and began his career in the police department during British rule in Odisha. However, his profound passion for Ayurveda and his fascination with the healing properties of herbs used by tribal communities inspired him to explore and promote traditional herbal medicine for the benefit of ordinary individuals. After retiring from government service, Mishra authored several books in the Odia language addressing various ailments and their Ayurvedic remedies. He established his pharmacy to prepare medicines based on his extensive experience and tested herbal combinations. His legacy continues through his son, the late Kabiraj Ganesh Mishra, and his wife, Dr. Smt. Sailabala Devi, who currently provides treatment at their residence in Puri. In addition to his contributions to Ayurveda, Kabiraj Laxman Mishra played a significant administrative role within the Temple Administration of the Sri Jagannath Temple in Puri. He served as the President of the Governing Body Council of Gopabandhu Ayurveda Mahavidyalaya and as Chairperson of the Governing Body Council of Samanta Chandra Sekhar College of Puri. In recognition of his impactful work, he was awarded the title of Ayurveda Siromani in 1987 by the Nikhila Utkala Ayurveda Baidya Sammilani. A committed social worker, Mishra also organized free medical camps to provide essential healthcare services to individuals from low socio-economic backgrounds.
Rasacharya Pandit Chivukula Satyanarayanasastry: A proponent of Rasa Chikitsa and a distinguished litterateur who enriched Ayurveda through Telugu literature
Authors: Gopod Savita P. , Anumol Kumaran 
Published: November 2024

Abstract
Alchemy has two main aspects: Rasa Chikitsa and Rasa Vada. Rasa Chikitsa refers to the therapeutic application of drugs of metal and mineral origin, animal products, and poisonous plant drugs in Ayurveda. On the other hand, Rasa Vada was a branch of chemistry in the Middle Ages concerned with changing base metals into gold and alchemy, which have been around for centuries. Saint Govinda Bhagavatpada, the mentor of Adi Sankaracharya, was a respected practitioner of Rasa Vada and wrote Rasa Hridaya Tantra, considered a pioneering work on Rasa Sastra. Rasacharya Chivukula Satyanarayana Sastry, from Andhra Pradesh, dedicated his life to mastering these two facets and gained notable recognition as a Rasa Vaidya. He was given the esteemed title of Rasacharya, following the footsteps of the renowned scientist Siddha Nagarjuna. Interestingly, no one else in Andhra Pradesh has been given this honor. However, recent discoveries suggest that Sri Bhudev Mookerji was also honored with the title “Rasacharya” for compiling the monumental publication Rasa Jala Nidhi in five volumes. This comprehensive discussion aims to shine a light on the extraordinary life and significant contributions of Rasacharya Sri Chivukula Satyanarayan Sastry, an outstanding figure in Ayurveda.
A journey through the inspiring life of Brahmasri VMC Sankaran Namboodirippad: An eminent toxicologist and an ardent guru
Authors: Shankar K. M. Pratap , Deep Valiparambil Chandran 
Published: November 2024

Abstract
The present paper sheds light on the phenomenal and inspiring life of Brahmasri VMC Sankaran Namboodirippad, a toxicologist in Ayurveda and a renowned physician from the central part of Kerala. The article presents the life profile of Sri Namboodirippad after meticulous documentation through a series of interviews and information from other literary sources. The information available about his childhood life, education, treatment experiences, and contributions as a teacher of Ayurveda is presented here. Sri Namboodirippad, born in an orthodox Namboodiri family, was a multifaceted personality who inspired aspirants of Ayurveda from the new generation not only from India but also from abroad. This article enlists a few of his treatment experiences in various toxicological and disease conditions that enlightened the minds of his students. This article ends with a note on his contribution as a teacher who transformed students from various clans to understand the importance of the fundamentals of Ayurveda in the prevention and treatment of human ailments.
Padmasree Dr. P.R. Krishnakumar – A life truly ahead of time
Authors: Sasikala Asha , Meledam Pratap Shankar Kizhakke , Thugutla Maheswar 
Published: November 2024

Abstract
This study details the life journey of Padma Shri Dr. P. R. Krishnakumar, a luminary who has contributed a lot to elevating Ayurveda’s global standing. This study unveils his childhood, education, and transformative journey through interviews with key informants and family members. It also presents his multi-faceted role as a researcher, manufacturer, academician, and administrator, emphasizing his commitment to maintaining traditional principles in Ayurveda while embracing modernization. Dr. Krishnakumar’s efforts facilitated the global acceptance of Ayurveda through collaborations, clinical trials, and international engagements. This study highlights Dr. P. R. Krishnakumar’s principles, ethos, and lasting legacy in Ayurveda. His life serves as a profound lesson on maintaining balance across diverse roles while contributing to the advancement of Ayurveda on a global stage.
Life profile of Vaidyabhooshanam K. Raghavan Thirumulpadu – An exemplary legend in Ayurveda
Authors: Remya E. , Sreedharan Aswani Pulikunnel 
Published: November 2024

Abstract

Ayurveda is one of the renowned contributions of Traditional Indian Medicine to the globe. Kerala has a rich legacy of Ayurveda, which has flourished and is supported by many distinguished traditional Vaidya families and legends. Shri Padmabhooshan Vaidyabhooshanam K. Raghavan Thirumulpadu (VKRT) is an impeccable contribution of Kerala for its Ayurvedic heritage. VKRT was a perfect blend of knowledge in Ayurvedic principles and practice and contemporary medical science. This article presents the life profile of VKRT, a profound Ayurvedic physician, prolific writer, and philosopher. This work is based on interviews conducted with his son Dr. K. Murali, his disciple Dr. M. Prasad and books and articles written by and on VKRT. The article highlights the various domains of VKRT’s personal and professional life. VKRT’s early life and education, destiny to study Ayurveda, multiple realms of his professional life, awards and achievements are discussed in detail.
Professor Damodar Joshi: A life that shaped the Ayurveda Pharmaceutics
Authors: Singh Thakur Rakesh , Singh Yashika , Joshi Yogeshwar Prasad 
Published: November 2024

Abstract
The study presents a comprehensive life profile of Professor (Prof.) Damodar Joshi and his professional trajectory within the domain of Ayurvedic pharmaceutics. His pivotal role in integrating Rasa Shastra and Bhaishajya Kalpana with contemporary scientific paradigms, specifically focusing on the analysis and advancements related to mineral/metallic formulations derived from different metal and mineral sources, is highly regarded in modern Rasa Shastra. The present study unfolds Prof. Damodar Joshi’s scientific accomplishments, advances in literature, and resolution of scientific quandaries under his mentorship, as well as his professional journey, post-retirement contributions, research publications, and an array of awards and recognitions received.
Life profile of Prof. Premvati Tewari: A visionary who pioneered the specialties of Prasuti Tantra, Stree-Roga, and Balaroga
Authors: Singh Renu , Prakash Om 
Published: November 2024

Abstract
Dr. Premvati Tiwari, an Ayurvedic luminary, was born and raised in a society that offered few opportunities for women to pursue studies. With her family’s support and firm resolve, she paved the way to become a successful academician, clinician, and researcher in the fields of Prasuti Tantra, Stree-Roga, and Balaroga. She was a proficient writer, excellent practitioner, and surgeon. She was a member of various governing bodies, selection committees, and research groups and a recipient of several national-level awards in Ayurvedic Sciences. She supervised over 70 MD and PhD scholars and authored many research articles and books. The life and contributions of Dr. Premvati Tiwari would inspire generations to come as an idol of perseverance, hard work, dedication, and service to society.
Kaviraj Gangadhar Roy: Catalyst of Ayurveda’s revival in the 19th century
Authors: Saha Suparna , Bhushan Shakti , Gajji Babu 
Published: November 2024

Abstract
Kaviraj Gangadhar Roy was a prominent figure in the nineteenth century who played a crucial role in revitalizing Ayurveda, which had been neglected during Muslim rule. His significant contributions include founding the Gangadhar Niketan in Murshidabad, which marked the beginning of the “Gangadhar Era,” which restored Ayurveda’s importance in the nation. His commentary on the Charak Samhita titled “Jalpakalpataru” is highly regarded for its innovative insights into Ayurvedic philosophy. He authored 76 books covering Ayurveda and Sanskrit literature, which enriched the field and attracted many scholars, including Dwarakanath Sen and Pareshnath Sen. The influence of his teachings reached cities like Jaipur, Haridwar, Varanasi, and Delhi, demonstrating his lasting legacy in shaping modern Ayurvedic practices. This brief overview highlights Kaviraj Gangadhar Roy’s crucial role in the revival of Ayurveda and the significant impact of his disciples on the field.
Evolution of Non-muscle Invasive Bladder Cancer Diagnostics: Vesical Imaging Reporting and Data System and Biomarkers
Authors: Deshpande Rohit Sanjay , Gorsi Ujjwal , Mavuduru Ravimohan Suryanarayan 
Published: November 2024

Summary
The majority of bladder cancer cases are non-muscle-invasive bladder cancer (NMIBC), and prompt, precise identification is crucial for optimal patient care. NMIBC diagnostic techniques have changed dramatically over time due to the necessity to enhance monitoring, risk assessment, and early identification. The discovery of biomarkers that can enhance diagnostic precision and outcome prediction, as well as the development of innovative imaging methods like the Vesical Imaging Reporting and Data System (VI-RADS), are two significant areas of progress.
Alternative Therapy to Intravesical Bacillus Calmette–Guerin in Nonmuscle Invasive Bladder Cancer
Authors: Arulraj Kevin , Ghorai Rudra Prasad , Nayak Brusabhanu 
Published: November 2024

Summary
Intravesical Bacillus Calmette-Guerin (BCG) is recommended as an adjuvant therapy for intermediate and high-risk bladder cancers following complete resection. However, up to 45% of patients receiving BCG experience treatment failure. High failure rates along with increased toxicity and a global shortage of BCG availability have led to the search for alternative agents which can replace BCG. These agents can be used as second-line therapies after BCG failure before considering patients for radical cystectomy. Intravesical chemotherapeutic agents such as gemcitabine, docetaxel, valrubicin, sequential gemcitabine-docetaxel, and sequential valrubicin-docetaxel have been shown to yield comparable or better outcomes compared to BCG with low toxicity. Newer methods of drug delivery such as chemohyperthermia (CHT), electromotive drug administration (EMDA) and targeted releasing system 200 (TAR-200) have been reported to amplify drug delivery and enhance outcomes. The immune checkpoint inhibitor pembrolizumab has been used for BCG unresponsive disease with satisfactory response rates but with a higher risk of adverse events. A newer immunotherapeutic agent, ALT-803/N-803, which is an interleukin 15 superagonist, has shown promising short-term results. Novel oncolytic viral delivery systems such as nadofaragene-firadenovac, CG0070, CG0070-pembrolizumab have been shown to alter immune response and destroy malignant cells with good short-term outcomes. The number of BCG alternatives has surged in the recent past and newer agents continue to emerge. Expanding the study populations and long-term follow-up will enable affirming these alternatives as BCG equivalents in the future.