bluuebunny/crossref_metadata_2025_split huggingface dataset:
Enhancing reactive agility in soccer: The impact of stroboscopic eyewear during warm‐up across fatigued and non‐fatigued conditions
Authors: Zwierko Teresa , Tapia Vicente , Vera Jesús , Redondo Beatriz , Morenas‐Aguilar María Dolores , García‐Ramos Amador 
Published: November 2024

AbstractAlthough prolonged training with stroboscopic eyewear has demonstrated potential for enhancing visuomotor skills, the acute effects of stroboscopic stimulation are not well understood. The aim of the study was to investigate the short‐term effects of stroboscopic exposure during the ball‐specific phase of soccer warm‐up on agility performance in preplanned and unpredictable (RA) tasks. Also, these effects were examined both in tasks involving ball dribbling and without the ball, as well as under fatigued and non‐fatigued conditions. Twenty‐two male soccer players participated in three sessions: a familiarization session and two experimental sessions, one with and one without stroboscopic exposure during the warm‐up. RA was assessed before and after each session using the 10‐repetition Illinois Agility Test, with and without ball control. Results showed that stroboscopic exposure significantly enhanced RA performance in tasks involving ball dribbling (p < 0.001, effect size (ES) = 0.57), and these effects were maintained under fatigued conditions (p = 0.007, ES = 0.39). However, there were no significant improvements in RA without the ball (p > 0.05). Exercise‐induced fatigue reduced RA performance in both conditions (F = 28.2; p < 0.001), regardless of warm‐up type (F = 0.5; p = 0.484). Additionally, stroboscopic exposure did not significantly affect the changes of direction speed performance in the Illinois Agility Test (F = 0.5; p = 0.479). These findings suggest that integrating stroboscopic eyewear into the ball‐specific phase of soccer warm‐ups effectively improves RA performance in tasks involving dribbling under both non‐fatigued and fatigued conditions. The effectiveness of acute stroboscopic stimulation is closely related to the specificity of the tasks in which it is applied. These insights could benefit training across various sports, encouraging coaches to adopt this approach to enhance player preparation before both training and competitions.
Optimal Solar‐Biomass‐Diesel‐Generator Hybrid Energy for Water Pumping System Considering Demand Response
Authors: Amusan Olumuyiwa Taiwo , Nwulu Nnamdi Ikechi , Gbadamosi Saheed Lekan 
Published: November 2024

ABSTRACTThe water pumping system is a vital daily operation for a sustainable society. The demand for this essential commodity is progressively growing around the world. Incorporating renewable energy sources (RES) into its operation mitigates adverse environmental effects stemming from greenhouse gas (GHG) emissions and reduces associated costs linked to fossil fuel energy sources. Hence, the optimal sizing of a hybrid mix of RES and non‐RES energy sources to power water pumping is essential. This study employs a generalized reduced gradient (GRG) optimization method to ascertain the most effective energy mix for water pumping system (WPS) application by integrating time of use demand response. This is achieved through four scenarios: Scenario 1 (S1) utilizes grid power and Diesel generator (DG) energy sources, Scenario 2 (S2) incorporates grid power, DG, and solar PV, Scenario 3 (S3) integrates grid power, DG, solar PV, and biomass energy sources, while Scenario 4 (S4) incorporates Time of Use (TOU) with the three aforementioned energy sources. The key findings reveal an ideal solution comprising of a mix of renewable PV and biomass along with non‐renewable grid energy source embedded with Time of Use demand response (S4) with optimal energy capacities of 4007 kW of PV, 4228 kW of grid, 234 kW of biomass, and 1085 of DG owing to the least cost energy and cost of water pumped of 0.75$/kW and 1.74$/kL, respectively, most volume of water pumped of 270.50 kL. These findings prove that the integration TOU demand response program with a hybrid mix of grid‐biomass‐DG‐solar PV is best suited for water pumping applications as it gives a cost‐competitive value.
Multiple intracerebral hematomas during SEEG recording and intradural hemorrhage after spinal tap: A case report prompting more research on collagen IV gene mutation and oral nicotine consumption as risk factors
Authors: Leitinger Markus , Broggi Serena , Spendel Mathias , Kalss Gudrun , Petrović Ivan , Krainz Herbert , Rossini Fabio , Höfler Julia , Toma Andreea , Kuchukhidze Giorgi , Mauritz Matthias , Poppert Kai‐Nicolas , Crespo‐Pimentel Bernardo , Bosque‐Varela Pilar , Pleyers Anna , Ganger Patricia , Kotzot Dieter , Lessel Davor , Griessenauer Christoph J. , Trinka Eugen 
Published: November 2024

AbstractIntracerebral hemorrhages (ICH) during implantation of stereo‐EEG electrodes are rare. The impact of tobacco‐free nicotine consumption on periprocedural bleeding is uncertain. We present a 20+ year‐old man with drug‐resistant epilepsy who underwent stereo‐EEG with 17 depth electrodes. Within a few days after insertion, the patient developed multiple ICHs in the electrode trajectories and an intradural hemorrhage after a diagnostic spinal tap. We performed the investigation of the clotting system and whole‐exome sequencing (WES). WES identified a heterozygous mutation c.4698G>T, p.(Trp1566Cys) in COL4A2 (NM_001846.4) encoding a collagen type‐IV alpha‐2 chain inherited from his seemingly healthy mother. As COL4A2 mutations had been identified in four adult patients with ICH we postulated that the identified variant presents a potential risk factor. Notably, mutations encoding other collagens have been linked to cerebral hemorrhages (COL4A1) and increased propensity to trigger ICH upon smoking (COL1A2). Our patient consumed at least 24 oral nicotine pouches (containing 11 mg nicotine each) per day. We consider the patient's COL4A2 mutation in combination with his substantial nicotine consumption as likely predisposition to multiple ICHs precipitated by stereo‐EEG. Patients with nicotine consumption and any collagen mutation may have a substantially higher risk for hemorrhagic complications in SEEG and other neurosurgical procedures.Plain Language SummaryA young man with drug‐resistant epilepsy experienced multiple intracerebral hemorrhages after implantation of SEEG electrodes for presurgical evaluation and concomitantly a intradural hemorrhage after a lumbar spinal tap. A collagen IV mutation of unclear significance and heavy use of oral nicotine pouches were the only potential risk factors identified. As collagen mutations were previously described risk factors and smoking in particular worsens the bleeding risk in collagen mutations, further research is warranted to prevent hemorrhages in neurosurgical procedures. Nicotine consumption in any form is a preventable risk factor.
Thermal Behaviour, Smoke Transfer and Antioxidant Analysis of Two Synthesised 2,5‐Dimethyl‐N‐Substituted Pyrrole Leucine Esters
Authors: Lai Miao , Li Pengyu , Yan Dingwei , Gao Ziting , Wang Haiyang , Gao Xue , Wei Yuewei , Chen Hongli , Yang Xiaopeng , Ji Xiaoming 
Published: November 2024

ABSTRACTThe limited availability of raw materials for cigarette aroma, particularly in emerging spices, highlights the need for proactive research in exploring and utilising new flavours. Pyrrole derivatives are an important class of five membered nitrogen‐containing heterocyclic compounds with beautiful aroma and excellent biological activity. By synthesising 2‐(2,5‐dimethyl‐1H‐pyrrol‐1‐yl)‐4‐methylpentanoic acid using the Paal–Knorr reaction followed by esterification reactions, novel pyrrole ester fragrances (5a and 5b) were obtained for further investigation. The two synthesised compounds were characterised using nuclear magnetic resonance spectroscopy (1H and 13C NMR), infrared spectroscopy (IR) and high‐resolution mass spectrometry (HRMS). Furthermore, the thermal properties, smoke transfer behaviour and antioxidant capacity of compounds 5a and 5b were evaluated. Thermogravimetric analysis (TG) revealed that compounds 5a and 5b exhibited major mass loss phases between 124.3°C–450°C and 116.8°C–450°C, respectively, with mass loss rates of 80.58% and 95.45%. Pyrolysis (Py) of compounds 5a and 5b resulted in the formation of eight and nine compounds, respectively. Moreover, the transfer rates of mainstream smoke particles from flavour additives 5a and 5b in tobacco shreds were higher compared with cigarette paper flavouring. Compound 5a demonstrated slightly higher antioxidant activity involving 2,2‐diphenyl‐1‐picrylhydrazyl (DPPH), hydroxyl radicals (•OH) and superoxide anion () than compound 5b. These findings support the development of new tobacco flavours and fragrance components and encourage further practical investigations.
Short‐Term Exposure of Bisphenol A Deteriorates the Quality of Rabbit Milk by Impairing Milk Fat Synthesis
Authors: Hao Jia , Beng Shaohui , Ma Zifeng , Xu Hongmei , Yang Ting , Yang Qiman , Wang Yunduan , Zheng Wenhui , Ma Yisha , Zhang Shuo , Kuang Liangde , Fu Wei 
Published: November 2024

ABSTRACTThis study aimed to investigate the effects of short‐term exposure of Bisphenol A (BPA) on the growth and lactation performance, blood parameters, and milk composition of lactating rabbits and explore its potential molecular mechanisms. Eight lactating rabbits with similar body weight were selected and randomly divided into the experimental group (BPA) and the control group (Ctrl). The group BPA was orally administered 80 mg/kg/day BPA on the 15th day postpartum, while the group Ctrl received a corresponding volume of vehicle. Blood and milk samples were collected after 7 days treatment. The results showed that short‐term ingestion of BPA did not obviously alter the body weight, feed intake, or milk yield of the lactating rabbits. ELISA assays indicated that BPA did not significantly affect the plasma levels of glutathione peroxidase (GSH‐Px), superoxide dismutase (SOD), creatinine (CRE), alanine aminotransferase (ALT), aspartate aminotransferase (AST), uric acid (UA), and urea. Utilizing untargeted metabolomics, we first depicted the metabolomic profile of rabbit milk, and identified 277 differential metabolites (DMs), with 141 DMs upregulated (e.g., BPA, and its metabolites including Cetirizine N‐oxide) and 136 DMs downregulated (e.g., Oleamide, Tiglic acid, PC O‐38:4) in the group BPA. KEGG analysis revealed that the DMs were mainly enriched in pathways comprising fatty acid metabolism, fatty acid degradation, and phosphatidylinositol signaling system, emphasizing the effect of BPA on milk fat metabolism. Hence, we established the BPA‐induced MAC‐T model, and the results showed that BPA significantly reduced cell viability and impacted lipid synthesis, as evidenced by reduced lipid droplets (BODIPY and Oil Red O staining) and decreased expression of genes related to lipid synthesis (e.g., PPARγ, ACACA, LPL). In summary, we first drew the metabolomic profile of rabbit milk and confirmed that short‐term BPA exposure impacted mammary lipid synthesis, thereby reducing the milk quality of lactating rabbits and providing fundamental data for resolving the toxicological mechanisms of BPA on mammal lactation.
Optimization of Ultrasound Extraction of Total Anthocyanin From Berberis kaschgarica Rupr. by Response Surface Methodology and Its Antihypertensive Effect
Authors: Khan Nawaz , Yusufu Maierdan , Ahmadova Zeynab , Maihemuti Nulibiya , Hailati Sendaer , Talihat Ziruo , Nueraihemaiti Nuerbiye , Dilimulati Dilihuma , Baishan Alhar , Duan Li , Zhou Wenting 
Published: November 2024

ABSTRACTBerberis kaschgarica Rupr. is a berry fruit shrub found in the north‐western region of China, locally its fruit is consumed as a tea ingredient a part of the daily diet, for treatment of different diseases like eczema, and for cardiovascular care as a traditional remedy. In the current study, an optimized ultrasound‐assisted extraction (UAE) method is developed using response surface methodology (RSM) to extract anthocyanins from the fruit. The influence of the extraction conditions on the yield of anthocyanins was evaluated and discussed. Additionally, the antihypertensive activity of the extract was evaluated in rats. The negative control group comprised Wistar–Kyoto rats, while five experimental groups included spontaneously hypertensive rats: model group; captopril group; and three treatment groups receiving purified extract. Blood pressure was regularly monitored every 2 weeks during the 12‐week treatment period. Post‐treatment left ventricular cardiac function in rats was assessed, and serum level of renin (REN), angiotensin‐converting enzyme (ACE), angiotensin II (Ang‐II), angiotensin‐(1–7) (Ang‐(1–7)), endothelin‐1 (ET‐1) and nitric oxide (NO) were evaluated. The optimal UAE extraction condition determined by RSM was 56.5% ethanol volume, 1:19.74 solid‐to‐liquid ratio, 55 min extraction time, and 0.71% of HCL volume. The purified B. kaschgarica anthocyanin extract exhibited antihypertensive effects and significantly improved left ventricular cardiac functions in treated rats. Furthermore, serum levels of REN, ACE, Ang‐II, ET‐1, Ang‐(1–7), and NO showed statistically significant changes in the treated groups. This study highlights the efficacy of the developed optimized UAE method for high‐yield anthocyanin extraction from B. kaschgarica fruit and its potential as a therapeutic agent for hypertension.
Cesarean Section, Childhood Health, and Schooling: Quasi‐Experimental Evidence From Denmark, Norway and Sweden
Authors: Rogvi Jessica á , Bütikofer Aline , Krebs Lone , Mühlrad Hanna , Wüst Miriam 
Published: November 2024

ABSTRACTDespite being one of the most common surgical procedures in industrialized countries, there is limited causal evidence on the long‐term consequences of Cesarean section (CS). We study the impacts of CS on health during ages 1–12 years and human capital outcomes at age 16 years, using exogenous variation in the probability of receiving a CS for breech births at term—a group with high CS risk. We use administrative data from Denmark, Norway, and Sweden to show that preventing complicated vaginal births benefits health at birth and reduces the number of all‐cause hospital nights during childhood. Our findings for childhood diagnoses for asthma, allergies, diabetes mellitus type 1, and school outcomes are imprecise and do thus not lend strong support for prominent hypotheses on CS causing long‐term immune dysfunction disorders and, thereby, worse human capital outcomes.
Managers’ Experience of the Response of the Health System to the Covid‐19 Pandemic for Inpatient Geriatric Care: Lessons About Organisation and Resilience
Authors: Uvhagen Håkan , Tolf Sara , Carlsson Karin Solberg , Øvretveit John , Flink Maria , Sparring Vibeke 
Published: November 2024

ABSTRACTBackgroundEffective management of crises is a major challenge for healthcare organisations and their managers. Research suggests that to respond to evolving and unpredictable crises, such as the Covid‐19 pandemic, an organisation needs the capability to continually adapt to the changing situation using relevant knowledge. However, there are few empirical studies using an organisational resilience perspective to understand how a health system responds to this type of crisis. This study aimed to describe managers' perspectives on what influenced the response to the Covid‐19 pandemic in the Region Stockholm healthcare system for older people.MethodsData collection was conducted through in‐depth semi‐structured interviews with assistant managers (n = 3) and managers of inpatient geriatric services outside of acute care hospitals (n = 8), managers of three acute care hospitals (n = 3); and the crisis management team for geriatric services (n = 3). Data was analysed using qualitative content analysis.ResultsCrisis management of geriatric care in the Stockholm healthcare system during the Covid‐19 pandemic's first 15 months was influenced by a combination of service specific aspects, ‘Internal flexible responses’, collaborative aspects, ‘Coordination within the system’, and governance aspects ‘Adaptive steering’.ConclusionsThis study contributes to empirical knowledge about organisational resilience. Managers' responses are facilitated when the governance allow them more flexibility in their internal responses and enable their cross‐organisational collaboration. A coordinating function across healthcare services is an important enabler in a crisis when the function has well‐established, trustful prior collaborations with the services.
Analysis of risk factors for very early preterm and early preterm birth in twins following in vitro fertilization and intracytoplasmic sperm injection–assisted pregnancy: A retrospective study
Authors: Yu Huaying , Zhang Songying , Chen Bin , Wei Minling , Xu Aike , Zhou Feng 
Published: November 2024

AbstractTo investigate the risk factors influencing very early preterm and early preterm births in twin pregnancies after in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI). This retrospective study analyzed 2042 twin pregnancies that underwent embryo transfer via IVF/ICSI at the Reproductive Center of Sir Run Run Shaw Hospital between January 2019 and December 2022. Spontaneous very early, early preterm, and provider‐initiated preterm births were examined separately. Based on gestational age, participants were categorized into three groups: very early preterm birth (<28 weeks), early preterm birth (≥28 to <34 weeks), and ongoing pregnancy (≥34 weeks). Univariate analysis was conducted to assess general conditions, among the three groups. Multiple logistic regression analysis was performed to identify independent risk factors for very early and early spontaneous preterm birth in twin pregnancies. A total of 2042 twin pregnancies were included in the study, with birth rates of 4.36% (89 of 2042) <28 weeks, 12.14% (248 of 2042) ≥28 to <34 weeks, and 83.50% (1705 of 2042) ≥34 weeks. The primary cause of provider‐initiated preterm birth <28 weeks was placental factors, while hypertensive disorders of pregnancy (31.11%) were the predominant cause for preterm births ≥28 to <34 weeks. Multiple logistic regression analysis identified the independent risk factors for births <28 weeks (P < 0.05) as cervical cerclage, history of late miscarriage or premature birth, uterine adhesions, primary infertility of polycystic ovary syndrome (PCOS), monochorionic pregnancies, history of cervical surgery, uterine malformations, body mass index ≥25 kg/m2, and uterine longitudinal axis lengths <3.6 cm. Cervical cerclage, main factors of infertility (PCOS), adenomyosis, and uterine longitudinal axis lengths <3.6 cm were identified as independent risk factors for ≥28 to 34 weeks (P < 0.05). It is crucial to consider risk factors during IVF/ICSI treatment because of the high incidence of very early and early preterm twin pregnancies, which can be identified early and properly managed.
Vascular dysfunction in women with recurrent pregnancy loss: Possible association with antiphospholipid antibodies
Authors: Yang Titi , Okada Emi , Todoroki Maho , Liu Siyu , Athurupana Rukmali , Kataoka Kumie , Kashino Chiaki , Mitsui Takashi , Hasegawa Toru , Kamada Yasuhiko , Masuyama Hisashi , Nakatsuka Mikiya 
Published: November 2024

AbstractObjectiveAntiphospholipid antibodies (aPL) are recognized to have a pivotal role in recurrent pregnancy loss (RPL) and cardiovascular disease. Therefore, we assessed the vascular function of women with RPL and examined the association with each type of aPL.MethodsIn this retrospective study, 569 women with RPL and 55 healthy women who had never experienced pregnancy loss were recruited. We performed blood tests for aPL and acceleration plethysmography (APG) to evaluate peripheral vascular function.ResultsThe differential pulse wave index (DPI), indicating vascular elasticity, was significantly lower in women with RPL (115.6 ± 4.1) compared to the control group (117.0 ± 2.3). DPI in RPL women with anti‐β2 glycoprotein I (aβ2GPI) IgG was significantly lower than those without. Remained blood volume (RBV), indicating post‐vasoconstriction blood content, was significantly higher in RPL women with aβ2GI IgG than in those without. Regression analysis showed aβ2GPI IgG and body mass index (BMI) linked negatively with DPI.ConclusionWomen with RPL have subclinical vascular dysfunction even at reproductive age. It is possible that aβ2GPI IgG is associated with vascular dysfunction in RPL women.
Afebrile tuberculous prostatic abscess with rectal fistula after intravesical Bacillus Calmette‐Guérin immunotherapy
Authors: Sawada Tatsuhiro , Igarashi Ayaka , Arai Seiji , Ohtsu Akira , Fujizuka Yuji , Nakazawa Shun , Sekine Yoshitaka , Koike Hidekazu , Furuya Yosuke , Suzuki Kazuhiro 
Published: November 2024

IntroductionIntravesical Bacillus Calmette‐Guérin immunotherapy is generally a safe treatment for non‐muscle‐invasive bladder cancer but sometimes causes complications.Case presentationThe patient was an 80‐year‐old man who had undergone Bacillus Calmette‐Guérin immunotherapy for non‐muscle‐invasive bladder cancer. Two months later, he developed an irregular pelvic mass surrounding the prostate and rectum with no fever. A colonoscopy showed purulent mucus discharge in the lower rectum, and a CT‐guided needle biopsy revealed epithelioid granuloma containing Langhans giant cells. Although acid‐fast bacteria culture and PCR of biopsy samples were negative, he was clinically diagnosed with Bacillus Calmette‐Guérin‐related tuberculous prostatic abscess spreading to the rectum. After receiving combined antitubercular drugs for 6 months, his discomfort disappeared with almost complete shrinkage of the prostatic abscess.ConclusionTuberculous prostatic abscess is a rare complication associated with Bacillus Calmette‐Guérin immunotherapy and sometimes induces rectal fistula. Conservative treatment with antitubercular drugs is efficient and safe for treatment of tuberculous prostatic abscess.
Role of the initiation factor 3 in the fidelity of initiator tRNA selection on ribosome
Authors: Singh Jitendra , Varshney Umesh 
Published: November 2024

AbstractInitiation factors play critical roles in fine‐tuning translation initiation, which is the first and the rate‐limiting step in protein synthesis. In bacteria, initiation factors, IF1, IF2 and IF3 work in concert to accurately position the initiator tRNA (i‐tRNA) in its formyl‐aminoacyl form, and the mRNA start codon at the ribosomal P‐site, setting the stage for accommodation of the aminoacyl‐tRNA in response to the second codon, and formation of the first peptide bond. Among these, IF3 is particularly crucial in ensuring the fidelity of translation initiation as it is involved in the accuracy of the selection of i‐tRNA and the start codon. The two‐domains (N‐ and C‐terminal) dumbbell shaped structure and dynamics of IF3 significantly influence its fidelity function. This review explores how the N‐ and C‐terminal domains of IF3 communicate with each other and how their interaction with i‐tRNA helps to maintain the fidelity of translation initiation.