bluuebunny/crossref_metadata_2025_split huggingface dataset:
Individualized quantification of the benefit from reperfusion therapy using stroke predictive models
Authors: Ozenne Brice , Cho Tae‐Hee , Mikkelsen Irene Klærke , Hermier Marc , Thomalla Götz , Pedraza Salvador , Roy Pascal , Berthezène Yves , Nighoghossian Norbert , Østergaard Leif , Baron Jean‐Claude , Maucort‐Boulch Delphine 
Published: July 2019

AbstractPurposeRecent imaging developments have shown the potential of voxel‐based models in assessing infarct growth after stroke. Many models have been proposed but their relevance in predicting the benefit of a reperfusion therapy remains unclear. We searched for a predictive model whose volumetric predictions would identify stroke patients who are to benefit from tissue plasminogen activator (t‐PA)‐induced reperfusion.Material and MethodsForty‐five cases were used to study retrospectively stroke progression from admission to end of follow‐up. Predictive approaches based on various statistical models, predictive variables and spatial filtering methods were compared. The optimal approach was chosen according to the area under the precision‐recall curve (AUPRC). The final lesion volume was then predicted assuming that the patient would or would not reperfuse. Patients, with an acute lesion of ≤50 ml and a predicted reduction in the presence of reperfusion >6 ml and >25% of the acute lesion, were classified as responders.ResultsThe optimal model was a logistic regression using the voxel distance to the acute lesion, the volume of the acute lesion and Gaussian‐filtered MRI contrast parameters as predictive variables. The predictions gave a median AUPRC of 0.655, a median AUC of 0.976 and a median volumetric error of 8.29 ml. Nineteen patients matched the responder profile. A non‐significant trend of improved reduction in NIHSS score (−42.8%, p = .09) and in lesion volume (−78.1%, p = 0.21) following reperfusion was observed for responder patients.ConclusionDespite limited volumetric accuracy, predictive stroke models can be used to quantify the benefit of reperfusion therapies.
Back in Time? A Temporal Autobiographical Approach to Afghan Return Migration
Authors: van Houte Marieke 
Published: July 2019

AbstractRepatriation programmes for refugees and asylum seekers are based on the assumption that going ‘home’ is the most desirable thing to do to restore the social order that was disrupted by conflict. Yet the often‐limited success of these programmes as migration management solutions, shown in poor reintegration results and re‐emigration, shows that there is a need for a better understanding of the lived experiences of (return) migrants. This article studies Afghan managed and “spontaneous” return migrants from Europe through an innovative temporal autobiographical approach, using both verbal and creative participatory narrative methods. I find that some migration movements were experienced as disruptive, while others were not, and that return sometimes meant a return to a previous life, sometimes a continuation, and sometimes the start of something new. I conclude that migration management programmes aimed towards “durable solutions” and the wellbeing of returnees should enable rather than constrain post‐return mobility.
Communication and cognitive impairments and health care decision making in MND: A narrative review
Authors: Paynter Camille , Cruice Madeline , Mathers Susan , Gregory Heidi , Vogel Adam P. 
Published: July 2019

AbstractRationaleMotor neurone disease (MND) is a neurodegenerative disease presenting with progressive weakness of voluntary muscles. For any condition, person‐centred health care relies on the sharing of information and a mutual understanding of the person's needs and preferences. Decision making in MND becomes more complex as there is no cure and a high prevalence of co‐morbid communication and/or cognitive difficulties.ObjectiveTo identify the reported impact of communication and/or cognitive impairment on patient and carer involvement in health care decision making in MND.MethodsA review and synthesis of studies addressing issues of communication impairment and/or cognitive impairment in relation to decision making focussed on MND was conducted. Articles were excluded if they were reviews, case studies, conference papers, or commentaries. To be included studies needed to address issues of communication impairment or cognitive impairment specifically in relation to decision making. Relevant data were extracted verbatim and subjected to content analysis to support the narrative summary.ResultsSeventy‐six articles were identified, and 35 articles screened. Six articles met inclusion criteria each describing examples of decision making in MND. There was limited data related to communication and/or cognitive impairment, and the impact these impairments may have on decision making despite recognition that many people with MND may lose verbal communication or develop subtle cognitive impairments. The literature is primarily from the perspective of others.ConclusionThis review highlights that the current body of literature exploring decision making within the MND population presents us with extremely limited insights into the impact of communication and/or cognitive impairments on health care decision making. Extant literature focuses on interventions (namely, ventilation and gastrostomy), the broad process of decision making, or cognitive assessment of decision‐making ability. Whilst most studies acknowledge that deficits in communication or cognition impact the decision‐making process, this issue is not the focus of any study.
“Ectrogella” Parasitoids of the Diatom Licmophora sp. are Polyphyletic
Authors: Garvetto Andrea , Perrineau Marie‐Mathilde , Dressler‐Allame Melina , Bresnan Eileen , Gachon Claire M. M. 
Published: July 2019

AbstractThe diatom genera Licmophora and Fragilaria are frequent epiphytes on marine macroalgae and can be infected by intracellular parasitoids traditionally assigned to the oomycete genus Ectrogella. Much debate and uncertainty remains about the taxonomy of these oomycetes, not least due to their morphological and developmental plasticity. Here, we used single‐cell techniques to obtain partial sequences of the parasitoids 18S and cox2 genes. The former falls into two recently identified clades of Pseudo‐nitzschia parasites temporarily named OOM_1_2 and OOM_2, closely related to the genera of brown and red algal pathogens Anisolpidium and Olpidiopsis. A third group of sequences falls at the base of the red algal parasites assigned to Olpidiopsis. In one instance, two oomycete parasitoids seemed to co‐exist in a single diatom cell; this co‐occurrence of distinct parasitoid taxa not only within a population of diatom epiphytes, but also within the same host cell, possibly explains the ongoing confusion in the taxonomy of these parasitoids. We demonstrate the polyphyly of Licmophora parasitoids previously assigned to Ectrogella (sensu Sparrow, 1960) and show that parasites of red algae assigned to the genus Olpidiopsis are most likely not monophyletic. We conclude that combining single‐cell microscopy and molecular methods is necessary for their full characterisation.
Clinical Cases in Hepatitis: Towards improving liver disease management in Australia
Authors: Strasser Simone I , Thompson Alexander J , Roberts Stuart K , George Jacob ,   Clinical Cases in Hepatitis 2018 Steering Committee
Published: July 2019

AbstractClinical Cases in Hepatitis 2018 was an interactive educational program for Australian physicians (gastroenterologists, hepatologists, and infectious disease specialists) actively involved in the treatment of liver diseases including hepatitis C virus, hepatitis B virus, and non‐alcoholic steatohepatitis. This educational program sponsored by Gilead Sciences took place on October 12–13, 2018, and provided timely, informative case‐based, and practical education to Australian physicians. This report summarizes keynote lectures from international leaders in the field of hepatitis C virus, hepatitis B virus, and non‐alcoholic steatohepatitis and practical clinical case studies designed to inform and educate Australian physicians on managing challenging patients.
Socioeconomic Status and Health Services Utilization for Children With Complex Chronic Conditions Liable to Receive Nurse‐Led Services: A Cross‐Sectional Study
Authors: Pérez‐Ardanaz Bibiana , Morales‐Asencio José Miguel , García‐Piñero José Miguel , Lupiáñez‐Pérez Inmaculada , Morales‐Gil Isabel María , Kaknani‐Uttumchandani Shakira 
Published: July 2019

AbstractAimTo analyze the use of health services for children with severe chronic diseases, seeking to identify patterns of use according to sociodemographic and clinical conditions, and to identify unmet needs of care coordination that could benefit from nursing case management services.DesignCross‐sectional study.MethodsChildren treated in ambulatory and hospital care in Granada, Spain, with complex chronic diseases in 2016 were analyzed to determine their use of healthcare resources. Socioeconomic variables were evaluated, along with clinical status and duration of their conditions.ResultsIn total, 265 children were analyzed (mean age 7.3 years, SD 4.63; 56.6% male). The average duration of the disease was 63.26 months (SD 54.09). The most common types of disease were neurological (35.80%), congenital (23.90%), and oncological (18.90%). Multivariate analysis showed that children in need of advanced care (β = 0.71), with a relatively recent diagnosis (β = ‐0.11), with criteria for palliative care 1 (β = ‐0.26), and whose mothers were older (β = 0.36) and had a higher educational level (β = 0.19) made greater use of healthcare resources during the preceding 12 months, whether urgent or scheduled (r2 = 78.0%, p < .001).ConclusionsChildren with higher needs for advanced care have a heterogeneous use of healthcare resources depending on certain clinical and sociodemographic determinants. This finding highlights the importance of the identification of profiles of children and families for care coordination. The presence of sociodemographic determinants may need individualized approaches to assure a timely health care utilization.Clinical RelevanceA significant proportion of the children used multiple health services, being treated at several centers simultaneously, and producing up to 139 total yearly contacts with the health system. Policymakers, healthcare providers, and patients’ families should engage in a redesign of healthcare services for these children, providing comprehensive and coordinated systems of care for this population.
Laparoscopic surgery with spleen preservation to treat primary splenic pregnancy: Case report and literature review
Authors: Wang Mengyao , Mo Siping , Yao Yuan , Li Jinke 
Published: July 2019

AbstractSplenic pregnancy is a rare form of ectopic pregnancy, with only 21 cases reported in PubMed since 1970. Here we report the case of a healthy 28‐year‐old woman with splenic pregnancy who complained of menolipsis lasting 56 days and left upper quadrant pain lasting 30 days. The level of β‐human chorionic gonadotropin in serum was 8399 mIU/mL, and transvaginal ultrasonography showed the uterine cavity to be empty without signs of adnexal mass. Subsequent abdominal ultrasonography detected a hyperechoic mass below the spleen containing an anechoic mass measuring 2.6 × 1.2 × 1.6 cm. Laparoscopy detected a gestational mass measuring 6.0 × 4.0 × 3.0 cm on the lower border of the spleen. Pregnancy tissues and a clot were removed under laparoscopic guidance, and the spleen was preserved. Our case suggests that removal of chorionic villi tissue, although not a standard procedure, may be effective for treating splenic pregnancy.
Basic fibroblast growth factor signalling regulates cancer stem cells in lung cancer A549 cells
Authors: Meng Yousheng , Bai Xiaoyan , Huang Yuandong , He Lang , Zhang Zhengwei , Li Xia , Cui Dandan , Yang Xuemei 
Published: July 2019

Abstract

Objectives
The basic fibroblast growth factor (bFGF)/fibroblast growth factor receptor (FGFR) signal transductional pathway plays an important role not only in tumour, but also in tumour stem cells. Thus, this study was designed to investigate the effects of bFGF signalling on cancer stem cells of lung cancer.

Methods
We blocked bFGF/FGFR signalling in cisplatin (DDP) selected A549 by knocking down bFGF via RNA interference, and subsequently, the stem cell marker of OCT-4 was determined, and cell proliferation, clone formation, invasiveness, apoptosis and drug resistance abilities of DDP selected A549 cells were investigated.

Key findings
The expressions of bFGF and OCT-4 in DDP selected A549 were higher than that of A549 cells. The findings suggested blocking of bFGF/FGFR signalling resulted in downregulation of bFGF, reduction in cell proliferation, clone formation, invasion and drug resistance abilities, and increase in cell apoptosis. Furthermore, our results also revealed OCT-4 was reduced after bFGF signalling blocking.

Conclusions
In conclusion, our study suggested that bFGF/FGFR signalling plays an important role in maintaining lung cancer stem cell characteristics and regulating expression of cancer stem cell marker of OCT-4.
The ‘Divine Names’ and the ‘Attributes of Deity’: On the (Infinite) Analogical Interval in Forty‐Six Aphorisms
Authors: Tromans Oliver 
Published: July 2019

AbstractFor the modern tradition of analytic philosophy of religion (that this article rejects), goodness, beauty, wisdom, and so on are divine attributes, whereas, for the classical tradition of Christian theology, they are divine names. This crucial distinction between attributes and names helps to explain why feminist philosopher Grace Jantzen’s charge of an identification of the male self with the divine self in Anglo‐American philosophy of religion leads on, directly, to a critique of the ‘doctrine’ of analogy. Jantzen’s critique of ‘classical theism’ is directed against the (largely modern) reduction of God to a (male) superbeing. Here, God’s ‘attributes’ are merely human ones, even if extended to a superlative degree. I distinguish the analogical reflections of Aquinas (following Dionysius) and his heirs from the anthropomorphic dissolutions of the divine in contemporary analytic philosophy of religion. Theology’s analogical speech, I argue, has the potential to answer – at least partially – the feminist critique of God as a ‘pure projection’ of ‘man’. For Aquinas, God’s perfections must be qualitatively different and not merely quantitative maximisations of our own. I contend that feminist philosophy of religion cannot afford to dismiss the potential of the way of analogy, especially in its negative or apophatic dimensions.
The Link between Discrimination and Worst Point Suicidal Ideation among Sexual and Gender Minority Adults
Authors: Salentine Cassidy M. , Hilt Lori M. , Muehlenkamp Jennifer J. , Ehlinger Peter P. 
Published: July 2019

ObjectiveSexual and gender minority (SGM) adults often report a disproportionately high rate of suicidal ideation compared to their heterosexual and cisgender counterparts. The current study aimed to understand the relationship between discrimination for one's sexual orientation or gender identity and suicidal ideation. We hypothesized that discrimination would be associated with suicidal ideation at one's worst point through the indirect effects of hopelessness regarding thwarted belongingness and perceived burdensomeness.MethodA sample of 178 SGM adults (M age = 30.34, range 18–69; 76% white) completed an online questionnaire assessing minority‐specific stressors and suicide‐related thoughts and behaviors.ResultsA mediation model with bootstrapping indicated that greater discrimination was associated with more frequent suicidal ideation at one's worst point through the indirect effect of hopelessness regarding thwarted belongingness.ConclusionsThe current study provides evidence that the pathway between discrimination and worst point suicidal ideation may be partially explained by the perception that one will never belong. These findings support the utility of an understudied Interpersonal Theory of Suicide hypothesis for research among SGM adults.
Differential muscle hypertrophy and edema responses between high‐load and low‐load exercise with blood flow restriction
Authors: Shiromaru Fabiano Freitas , de Salles Painelli Vitor , Silva‐Batista Carla , Longo Ariel Roberth , Lasevicius Thiago , Schoenfeld Brad J. , Aihara André Yui , Tricoli Valmor , de Almeida Peres Bergson , Teixeira Emerson Luiz 
Published: July 2019

We sought to determine whether early increases in cross‐sectional area (CSA) of different muscles composing the quadriceps with low‐load resistance training with blood flow restriction (LL‐BFR) were mainly driven by muscle hypertrophy or by edema‐induced swelling. We also compared these changes to those promoted by high‐load resistance training (HL‐RT). In a randomized within‐subject design, fifteen healthy, untrained men were submitted to magnetic resonance imaging (MRI) for CSA and edema‐induced muscle swelling assessment (fast spin echo inversion recovery, FSE‐STIR). MRI was performed in LL‐BFR and HL‐RT at baseline (W0) and after 3 weeks (W3), with a further measure after 6 weeks (W6) for HL‐RT. Participants were also assessed at these time points for indirect muscle damage markers (range of motion, ROM; muscle soreness, SOR). CSA significantly increased for all the quadriceps muscles, for both LL‐BFR and HL‐RT at W3 (all P < .05) compared to W0. However, FSE‐STIR was elevated at W3 for all the quadriceps muscles only for HL‐RT (all P < .0001), not LL‐BFR (all P > .05). Significant increases and decreases were shown in SOR and ROM, respectively, for HL‐RT in W3 compared to W0 (both P < .05), while these changes were mitigated at W6 compared to W0 (both P > .05). No significant changes in SOR or ROM were demonstrated for LL‐BFR across the study. Early increases in CSA with LL‐BFR seem to occur without the presence of muscle edema, whereas initial gains obtained by HL‐RT were influenced by muscle edema, in addition to muscle hypertrophy.
Private School Choice and Crime: Evidence From Milwaukee
Authors: DeAngelis Corey A. , Wolf Patrick J. 
Published: July 2019

ObjectivesThis study aims to determine if private school choice reduces the proclivity of students to commit crimes as adults.MethodsWe examine crime rates for young adults who experienced Milwaukee's citywide voucher program as high school students compared to matched public school peers using unique data collected as part of a longitudinal evaluation of the program.ResultsWe find that mere exposure to private schooling through a voucher is associated with lower rates of criminal activity, but the relationship is not robust to different analytic samples. Students who used the program through 12th grade, however, were much less likely to have criminal records than their public school peers. These results are apparent when controlling for a robust set of student demographics, test scores, and parental characteristics.ConclusionsWe conclude that merely being exposed to private schooling for a short time through a voucher program may not have a significant impact on criminal activity, though persistently attending a private school through a voucher program can decrease subsequent crime rates.
GENÇLERİN SENDİKAL ALGI VE TUTUMLARI ÜZERİNE BİR ARAŞTIRMA
Authors: PALAZ Serap , POYRAZ Olcay 
Published: July 2019

Gençler genellikle düşük ücretli, düşük statülü ve güvencesiz işlerde çalışmakta ve işgücü piyasasındaki konumları giderek daha fazla istikrarsızlığa maruz kalmakta dolayısıyla sendikal destek ve korumaya daha fazla ihtiyaç duymaları beklenilmektedir. Fakat tüm dünyada olduğu gibi, Türkiye'de de son yıllarda genç sendikalaşma oranı yetişkinlerin oranından daha hızlı düşmektedir. Bu çalışmada genç işgücünün düşük sendika üyelik oranlarının nedenleri arasında yer alan gençlerin sendikaya yönelik tutum ve davranışlarına odaklanılmaktadır. Çalışmanın evreni tam zamanlı/yarı zamanlı, dönemsel veya geçici olarak iş piyasasında yer alan 15-29 yaş grubunda yer alan gençler oluşturmaktadır. Veriler yüz yüze yapılan anket yöntemi ile toplanmış ve verilerin analizinde frekans dağılımı ve tanımlayıcı istatistikler kullanılmıştır. Çalışmanın bulguları bize gençlerin sendikal tutum ve algılarının olumsuz olmasından ziyade sendika konusunda yeterli bilgiye sahip olmadıklarını, sendikaların da kendilerini anlatma ve tanıtma konusunda yetersiz ve işlevsiz kaldığı sonucuna ulaşılmıştır.
Islam and Iconoclasm
Authors: Ozgur Alhassen Leyla 
Published: July 2019

Abstract
In the Qurʾān, Ibrāhīm is portrayed as breaking the idols that his people worship (21:51–73), a story that comes at the crossroads of a number of ethical issues, including the freedom of belief. In this study, I examine the issue through a number of different lenses: Qurʾānic commentary (tafsīr on the story), art history (Islam, art and iconoclasm), legal opinions (jurisprudence), philosophical approaches (civil disobedience), and literary analysis (focused on idolatry and Ibrāhīm in the Qurʾān). In looking at the issue from these various perspectives, I argue that analyzing the story as a form of civil disobedience, while using literary analysis, lends new insights and gives modern readers tools with which to bridge some of the moral and ethical issues at play in the story of Ibrāhīm breaking his people’s idols.
Words Made Flesh
Authors: Homrighausen Jonathan 
Published: July 2019

Abstract
This essay explores the potential of calligraphy for engaging sacred text through an analysis of two works by Donald Jackson, British calligrapher and creator of The Saint John’s Bible. Closely situating these works in the contexts of the twentieth-century Roman-alphabet calligraphy revival, in Jackson’s own career, in his own writings on calligraphy, and in the context of his medieval predecessors, reveals not only a visual but a multisensory exegesis of scripture through reading, seeing, hearing, touching, and moving. Through his use of lettering and gilding to engage many different sensory modalities, Jackson’s works exemplify the Bible’s role as an iconic text in which script becomes image. Theologically, they embody an incarnationality revealing the spirit of the scribe and the Spirit inspiring the scribe.
Lived Theology: Spirit, Economy, and Asceticism in Irenaeus and His Readers
Authors: Saieg Paul 
Published: July 2019

Abstract
Salvation lies at the heart of Irenaeus’ thought. His two surviving works not only declare helping his readers’ communities toward salvation as their purpose, but even contain prayers and meditations for the Valentinians’ salvation. However, following the paradigm set down by Harnack more than a century ago, scholars have tended to separate what Irenaeus insists “rejoice together”: “truth in the mind” and “holiness in the body” (Dem 3). By reconsidering the history of Irenaean scholarship on the nature of the divine economy and the infancy of Adam, I show that Adam’s infancy is temporal rather than physical and that Irenaeus’ interpretation of Adam’s growth is at the same time the phenomenological structure of temptation, maturation, and askesis experienced by the living reader. Irenaeus’ soteriology was not simply a metaphysical theory but an ascetic and even phenomenological discourse structuring a way of life—it was a lived theology.