bluuebunny/crossref_metadata_2025_split huggingface dataset:
FAKTOR-FAKTOR YANG BERHUBUNGAN DENGAN PERDARAHAN POST PARTUM PADA IBU BERSALIN DI RSUD PRINGSEWU TAHUN 2016
Authors: Anggraini Heni , Riansari Dewi 
Published: July 2018

Abstrak: Perdarahan post partum adalahperdarahanlebihdari 500-600 ml selama 24 jam setelah anak lahir termasuk perdarahan karena retensio plasenta. Perdarahan post partum adalah perdarahan dalam kala IV lebih dari 500-600 cc dalam 24 jam setelah anak dan plasenta lahir (Mochtar, 2008).Tujuan penelitian ini adalah untuk mengetahu ifaktor-faktor yang berhubungan dengan perdarahan post partum pada ibu bersalin di RSUD Pringsewu Tahun 2016. Jenis penelitian ini adalah penelitian kuantitatif, Rancangan penelitian menggunakan Crosssectional. Dalam rancangan penelitian ini mempunyai 560 populasi ibu bersalin yang melakukan persalinan di RSUD PringsewuTahun 2016. Teknik pengambilan sampel pada penelitian ini menggunakan random sampling, dan diperoleh sampel sebanyak 222 responden. Cara ukur dalam penelitian ini menggunakan rekam medik. Analisa data yang digunakan adalah analisa univariat dan analisa bivariat dalam bentuk table distribusi frekuensi. Hasil uji Chi-Square didapatkan bahwa pada atonia uteri P-Value = 0,009 (0,009 < 0,05). OR = 7,296, pada retensio plasenta P-Value = 0,000 (0,000 < 0,05). OR = 13,788, dan pada laserasi jalan lahir P-Value = 0,000 (0,000 < 0,05). OR = 9,118. Maka dapat disimpulkan bahwa Ha diterima ada hubungan antara variabel independen dan variabel dependen. Disarankan bagi seluruh tenaga kesehatan untuk dapat meningkatkan pemberian pelayanan khususnya pada ibu bersalin agar dapat menurunkan Angka Kematian Ibu (AKB) akibat perdarahan khususnya di Provinsi Lampung Abstract: Post partum bleeding is bleeding more than 500-600 ml for 24 hours after child have born, including bleeding because retensio placenta. Post partum pleading is bleeding in more than 500-600 cc in 24 hours after child and placenta was born (Mochtar, 2008). The aim of the research is to know the factors related to post partum bleeding mother maternity at RSUD Pringsewu in 2016. This research type is quantitative research, research design used crossectional. In this research design have 498 population of maternity that do deliveries at RSUD Pringsewu in 2016. Sampling technique counted 222 respondents. Measure method in this research used medical record. The data analysis that used is univariate analysis and bivariate analysis in the form of frequency distribution table. The result of chi-square test showed that in uterine atonia P-Value = 0,009 (0,009 < 0,05). OR = 7,296, padaretensioplasenta P-Value = 0,000 (0,000 < 0,05). OR = 13,788, danpadalaserasijalanlahir P-Value = 0,000 (0,000 < 0,05). OR = 9,118. So, it can be concluded that ha is accepted and the relationship between the independent variabel and the dependent variable. Recommended for all the health workers to can increase the provision of service, especially to mother maternity in order to can reduce the rate mortality to mother, especially in Provinsi Lampung.
Evaluation of somaclonal variants under field condition for the varietal improvement of strawberry (Fragaria × Ananassa Duch.) in Bangladesh
Authors: Ara T , Ogita S , Hossain MM , Islam AKMR 
Published: July 2018

The present study was conducted to standardize a suitable protocol for varietal improvement of strawberry through somaclonal variation using in vitro techniques. Leaf segments of seven strawberry varieties viz. AOG, JP-2. JP-3, Camarosa, Sweet Charly, Giant Mountain and Festival were used for callus induction and shoot regeneration. Regenerated plantlets were planted into the field to evaluate their morphological characters, yield contributing characters, response to fungal diseases and summer overcoming potentiality (%) of the transplanted plantlets compare with their parents and data were recorded. Among the seven strawberry varieties AOG was found to be the most responsive genotype for callus induction, shoot regeneration and rooting. A total of 40-45 somaclonal variants from each of the tested varieties were established and maintained in the field and were considered as R0 plants. There were no somaclones found resistance to fungal diseases but someone’s, specially AOG SC 3 showed better tolerance than the donor plants. Comparing with donor plants and other somaclones AOG SC 3 was found better summer overcoming potentiality. It can be acceptable commercially if the good characters exhibited are transmitted through generations or could be used in future breeding programme for the improvement of strawberry varieties in Bangladesh.J. bio-sci. 24: 19-32, 2016
Robust linear regression based simple interval mapping for QTL analysis with backcross population
Authors: Alam MJ , Alamin M , Hossain MR , Islam SMS , Mollah MNH 
Published: July 2018

Simple interval mapping (SIM) is one of the most important techniques for the identification of quantitative trait locus (QTL). Most of the approaches of SIM are very sensitive to phenotypic outliers and produce misleading results. There is a robust approach of SIM only for F2 population. However, there is no robust SIM method for Backcross population. The objective was to develop a new approach of SIM with Backcross population which is robust against phenotypic outliers and performs almost the same as existing classical methods in absence of outliers. Maximum likelihood (ML) and linear regression (LR) based approaches of SIM are not robust against phenotypic outliers. In this research, we have developed a robust regression based SIM approach by maximizing β-likelihood function for Backcross population. The proposed method reduces to the LR-based SIM method when β = 0. To measure the performance of the proposed method in comparison of ML and LR based SIM with backcross population; we have generated phenotypic and genotypic data for Backcross population using simulation technique. LOD score profile plot shows that the highest peaks of LOD scores occur in the true QTL positions of the true chromosomes at true markers by all three methods for the uncontaminated dataset. However, in presence of outliers, only the proposed method gives the highest LOD score peaks at the true QTL positions on the true chromosomes. The simulation results showed that the proposed method improves performance over the existing SIM methods in presence of phenotypic contaminations.J. bio-sci. 24: 75-81, 2016
German Medical Informatics Initiative
Authors: Semler Sebastian , Wissing Frank , Heyder Ralf 
Published: July 2018

SummaryThis article is part of the Focus Theme of Methods of Information in Medicine on the German Medical Informatics Initiative. The Medical Informatics Initiative (MII) was launched within the scope of the German Federal Ministry of Education and Research’s (BMBF) Medical Informatics Funding Scheme, with the goal of developing infrastructure for the integration of clinical data from patient care and medical research in Germany. Its work is to be performed over the course of a decade (2016–2025) across three funding phases, with the first two concentrating on university hospitals. During the conceptual phase (now concluded), a central supporting project ensured coordination – and laid the ground for standardised solutions for all the initiative’s sites and scientific consortia that will enable effective data use and exchange, both for health care as well as research. The conceptual phase focused on the following: a) interoperability, through the consistent use of international standards (from an early stage, i.e. primary IT systems in patient care); b) standardised templates for patient consent and harmonised data protection; and c) standard rules for data use and access (monitoring and safeguarding access to data). On this basis, the initiative aims in the long term to improve medical research (particularly health care research, using data from treatments), to accelerate the transfer of knowledge from research to patient care – and to provide important impetus for the digitalization of medicine in Germany.
Evidence for a Systematic Offset of −80 μas in the Gaia DR2 Parallaxes
Authors: Stassun Keivan G. , Torres Guillermo 
Published: July 2018

Abstract
We reprise the analysis of Stassun & Torres, comparing the parallaxes of the eclipsing binaries reported in that paper to the parallaxes newly reported in the Gaia second data release (DR2). We find evidence for a systematic offset of −82 ± 33 μas, in the sense of the Gaia parallaxes being too small, for brightnesses (G ≲ 12) and for distances (0.03–3 kpc) in the ranges spanned by the eclipsing binary sample. The offset does not appear to depend strongly on distance within this range, though there is marginal evidence that the offset increases (becomes slightly more negative) for distances ≳1 kpc, up to the 3 kpc distances probed by the test sample. The offset reported here is consistent with the expectation that global systematics in the Gaia DR2 parallaxes are below 100 μas.
Production of Cool Gas in Thermally Driven Outflows
Authors: Schneider Evan E. , Robertson Brant E. , Thompson Todd A. 
Published: July 2018

Abstract
Galactic outflows commonly contain multiphase gas, and its physical origin requires explanation. Using the Cholla Galactic OutfLow Simulations suite of high-resolution isolated galaxy models, we demonstrate the viability of rapid radiative cooling as a source of fast-moving (v ∼ 1000 km s−1), cool (104 K) gas observed in absorption-line studies of outflows around some star-forming galaxies. By varying the mass loading and geometry of the simulated winds, we identify a region of parameter space that leads to cool gas in outflows. In particular, when using an analytically motivated central feedback model, we find that cooling flows can be produced with reasonable mass-loading rates (

), provided that the star formation rate surface density is high. When a more realistic clustered feedback model is applied, destruction of high-density clouds near the disk and interactions between different outflow regions indicate that lower mass-loading rates of the hot gas within the feedback region may still produce multiphase outflows. These results suggest an origin for fast-moving cool gas in outflows that does not rely on directly accelerating cool gas from the interstellar medium. These cooling flows may additionally provide an explanation for the multiphase gas ubiquitously observed in the halos of star-forming galaxies at low redshift.
Absolute Hubble Space Telescope Proper Motion (HSTPROMO) of Distant Milky Way Globular Clusters: Galactocentric Space Velocities and the Milky Way Mass
Authors: Sohn Sangmo Tony , Watkins Laura L. , Fardal Mark A. , van der Marel Roeland P. , Deason Alis J. , Besla Gurtina , Bellini Andrea 
Published: July 2018

Abstract
We present Hubble Space Telescope (HST) absolute proper motion (PM) measurements for 20 globular clusters (GCs) in the Milky Way (MW) halo at Galactocentric distances

R

GC

≈
10
–
100

kpc, with a median per-coordinate PM uncertainty of 0.06

mas

yr

−
1

. Young and old halo GCs do not show systematic differences in their 3D Galactocentric velocities, derived from combining existing line-of-sight velocities. We confirm the association of Arp 2, Pal 12, Terzan 7, and Terzan 8 with Sgr. These clusters and NGC 6101 have tangential velocity

v

tan

>
290

km s−1, whereas all other clusters have

v

tan

< 200 km s−1. NGC 2419, the most distant GC in our sample, is also likely associated with the Sgr stream, whereas NGC 4147, NGC 5024, and NGC 5053 definitely are not. We use the distribution of orbital parameters derived using the 3D velocities to separate halo GCs that either formed within the MW or were accreted. We also assess the specific formation history of, e.g., Pyxis and Terzan 8. We constrain the MW mass via an estimator that considers the full 6D phase-space information for 16 of the GCs from

R

GC

=
10

to 40 kpc. The velocity dispersion anisotropy parameter

β
=

0.609

−
0.229

+
0.130

. The enclosed mass

M
(
<
39.5

kpc
)
=

0.61

−
0.12

+
0.18

×

10

12

M

⊙

, and the virial mass

M

vir

=

2.05

−
0.79

+
0.97

×

10

12

M

⊙

. These are consistent with, but on the high side among, recent mass estimates in the literature.
Méthodologie de l’État
Authors: Sueur Jean-Jacques 
Published: July 2018

La technique est un accélérateur du changement économique et social, elle en est rarement la cause. D’un autre côté, il est assez difficile, apparemment, de trouver dans le monde une « structure » assimilable à ce que la théorie générale du droit appelle traditionnellement un Etat (L. Stewart). Depuis la « grande transformation » (Polanyi) et la globalisation, les États occidentaux ont subi un grand nombre de bouleversements induits par l’économie numérique et la diffusion des théories et des pratiques managériales. D’autres se déroulent parallèlement qui sont encore plus profondes parce qu’elles affectent la structure de l’échange et par conséquent la nature de la société (financiarisation). Devant de telles transformations, la question se pose de savoir si nous sommes toujours dans le même monde. Répondre à une telle question nécessite la mise au point de méthodes qu’on peut appeler réalistes, applicables aux acteurs du jeu politique dont l’Etat vu comme concept et cadre de référence (et pas seulement comme puissance) fait partie, si l’on adopte un point de vue pragmatique. La question de l’Etat a longtemps été un terrain de jeu pour le « Droit des Professeurs » (J. Vanderlinden). Nous proposons ici une analyse critique, faisant de l’Etat et du politique, à la fois une grille de lecture de la société et un facteur de recomposition du rapport public/privé.
La vulnérabilité de l’État de droit espagnol dans le contexte de revendication indépendantiste catalane
Authors: Rojas-Hutinel Nilsa 
Published: July 2018

Cherchant à limiter les effets d’une nouvelle tentative d’indépendance catalane, le gouvernement espagnol a renouvelé les instruments juridiques de lutte contre les troubles portés à la stabilité de l’État. Pour autant, les mécanismes juridiques mobilisés tant pour empêcher la tenue du référendum d’autodétermination du 1 er octobre 2017 que pour annuler les actes visant à déclarer l’indépendance de la Catalogne n’ont pas suffi à modérer les agissements des institutions exécutive et législative catalanes. Il s’ensuit une fragilisation de l’État de droit espagnol. Les mécanismes traditionnels permettant de protéger l’État de droit (le contrôle de légalité et le contrôle de constitutionnalité notamment) ayant été remis en cause par les autorités catalanes, le gouvernement espagnol a fait usage d’un instrument constitutionnel exceptionnel visant à restaurer la légalité constitutionnelle rompue : l’article 155. Or, l’interprétation et l’application qui peuvent être faites de cet article font craindre une mise à mal de l’État de droit. À cela s’ajoute que le recours à l’article 155 n’éteint pas pour autant les motifs qui sont la cause de la rupture entre « pro » et « anti » indépendance.
Relationship Between Dry Retinal Volume and Visual Acuity in Diabetic Macular Edema
Authors: Nittala Muneeswar Gupta , Velaga Swetha Bindu , Hu Zhihong , Sadda SriniVas R. 
Published: July 2018

BACKGROUND AND OBJECTIVE:
To evaluate the relationship between a novel spectral-domain optical coherence tomography (SD-OCT) parameter, predicted dry retinal volume (DRV), and visual acuity (VA) in subjects with diabetic macular edema.

PATIENTS AND METHODS:
Twenty-eight eyes of 26 subjects with macular edema secondary to diabetic retinopathy (cases) and 10 healthy eyes of normal volunteers (controls) were included. Spectral-domain optical coherence tomography volume scans (512 × 128) were obtained before and 6 months to 12 months after anti-vascular endothelial growth factor therapy. The borders of the neurosensory retina, nerve fiber layer (NFL), and vitreous were manually defined using previously described grading software. NFL reflectivity was used to normalize the signal between eyes, allowing a normalized total retinal intensity to be computed for each eye by summing the brightness of every pixel in the retina on all B-scans. Using this normalized retinal intensity, a ratio of retinal intensity of cases over retinal intensity of normal was generated. The predicted DRV was computed by multiplying this calculated ratio with total retinal volume at baseline for each eye. Correlation analysis was performed between DRV at baseline and VA at baseline and final follow-up.

RESULTS:

The mean ± standard deviation age of the cohort was 69 years ± 9.8 years, and 28% were female. Mean best-corrected VA (logMAR) improved from 0.56 ± 0.36 at baseline to 0.44 ± 0.32 at follow-up (
P
= .001). The uncorrected (“wet”) total retinal volume of 13.25 mm
3
± 2.73 mm
3
at baseline declined significantly to a posttreatment retinal volume of 10.92 mm
3
± 1.42 mm
3
. The predicted DRV (10.79 mm
3
± 1.42 mm
3
) was statistically similar to the post-treatment, actual retinal volume. No significant correlation was observed between DRV and post-treatment VA.

CONCLUSIONS:
The predicted DRV at baseline showed good agreement with the actual observed posttreatment retinal volume. Thus, DRV may be a potentially useful parameter to estimate the extent of retinal tissue loss that may be obscured by the presence of concomitant edema. The lack of correlation between DRV and VA, however, suggests that other parameters, such as the integrity of the outer retinal bands, are likely important for visual outcome prediction.

[
Ophthalmic Surg Lasers Imaging Retina
. 2018;49:510–515.]
Ebola Immunity: Gaining a Winning Position in Lightning Chess
Authors: Ploquin Aurélie , Zhou Yan , Sullivan Nancy J. 
Published: July 2018

Abstract
Zaire ebolavirus (EBOV), one of five species in the genus Ebolavirus, is the causative agent of the hemorrhagic fever disease epidemic that claimed more than 11,000 lives from 2014 to 2016 in West Africa. The combination of EBOV’s ability to disseminate broadly and rapidly within the host and its high pathogenicity pose unique challenges to the human immune system postinfection. Potential transmission from apparently healthy EBOV survivors reported in the recent epidemic raises questions about EBOV persistence and immune surveillance mechanisms. Clinical, virological, and immunological data collected since the West Africa epidemic have greatly enhanced our knowledge of host–virus interactions. However, critical knowledge gaps remain in our understanding of what is necessary for an effective host immune response for protection against, or for clearance of, EBOV infection. This review provides an overview of immune responses against EBOV and discusses those associated with the success or failure to control EBOV infection.
Mycobacterial PknG Targets the Rab7l1 Signaling Pathway To Inhibit Phagosome–Lysosome Fusion
Authors: Pradhan Gourango , Shrivastva Rohini , Mukhopadhyay Sangita 
Published: July 2018

Abstract
Phagosome maturation is an important innate defense mechanism of macrophages against bacterial infections. The mycobacterial secretory protein kinase G (PknG), a serine/threonine kinase, is known to block phagosome–lysosome (P–L) fusion, and the kinase activity of PknG appears to be crucial for this. However, the detail mechanisms are not well understood. In the current study, we demonstrate that PknG of Mycobacterium sp. interacts with the human Rab GTPase protein, Rab7l1, but not with other Rab proteins as well as factors like Rabaptin, Rabex5, PI3K3, Mon1a, Mon1b, early endosome autoantigen 1, and LAMP2 that are known to play crucial roles in P–L fusion. The Rab7l1 protein is shown to play a role in P–L fusion during mycobacterial infection, and its absence promotes survival of bacilli inside macrophages. PknG was found to be translocated to the Golgi complex where it interacted with GDP-bound Rab7l1 and blocked transition of inactive Rab7l1-GDP to active Rab7l1-GTP, resulting in inhibition of recruitment of Rab7l1-GTP to bacilli-containing phagosomes, and these processes are dependent on the kinase activity of PknG. Localization of Rab7l1-GTP to phagosomes was found to be critical for the subsequent recruitment of other phago-lysosomal markers like early endosome autoantigen 1, Rab7, and LAMP2 during infection. Thus, by interfering with the Rab7l1 signaling process, PknG prevents P–L fusion and favors bacterial survival inside human macrophages. This study highlights a novel role of Rab7l1 in the phagosomal maturation process and hints at unique strategies of mycobacteria used to interfere with Rab7l1 function to favor its survival inside human macrophages.
Antisettici e controllo della carica batterica nelle ulcere venose/Antiseptics and control of bacterial load in venous ulcers
Authors: Nebbioso Giuseppe , Falasconi Ciro , Nebbioso Viviana , Petrella Francesco 
Published: July 2018

L’insorgenza di infezione su una lesione cutanea cronica determina un arresto del processo di riparazione tessutale e impone l’instaurazione di una terapia antibiotica sistemica che, in una fase iniziale, sarà empirica e, dunque, non scevra di insuccessi. L’utilizzo di antimicrobici con ridotto potere citotossoco/istiolesivo può essere considerata, in molti casi, una valida alternativa per il controllo della carica batterica e dell’infezione locale. L’associazione di antimicrobici a base di poliesanide biguanide, betaina e cadexomero iodico, in molti casi, permette di controllare/ridurre la carica batterica e l’infezione locale fungendo da starter per la ripresa del processo di riparazione tessutale.
The onset of infection on a skin ulcer (chronic wound) leads to a halt in the tissue repair process and requires a systemic antibiotic therapy which, at an early stage, will be empirical and, therefore, not free from setbacks. The use of antimicrobials with reduced cytotoxic/histiolesive power can be considered, in many cases, a valid alternative for bacterial burden and local infection control. The combination of antimicrobials based on polystyrene biguanide, betaine and iodine cadexomer, in many cases, allows to control/reduce the bacterial burden and local infection by acting as a starter for the resumption of the tissue repair process.
Utilizzo di staminali da tessuto adiposo nelle lesioni cutanee croniche: esperienza clinica/Use of adipose tissue stem cells in chronic skin lesions: clinical experience
Authors: Moffa Fabrizio , Balbiano da Colcavagno Alberico , Ricci Elia 
Published: July 2018

La guarigione di una ferita cronica è un processo articolato e complesso, che richiede una visione clinica globale del paziente. Tuttavia, il trattamento locale del letto della ferita riveste un’importanza fondamentale. Sempre più ormai si parla di medicina rigenerativa di tipo induttivo come mezzo per stimolare le cellule senescenti all’interno di una lesione cutanea cronica, in particolare mediante l’utilizzo delle cellule staminali mesenchimali. Il tessuto adiposo autologo rappresenta una fonte di cellule staminali e la tecnologia Lipogems® ne rende possibile la sua applicazione clinica. In questo studio vengono analizzati i risultati ottenuti con tale metodica che, seppur con i limiti di un numero ancora non consistente di pazienti, sono comunque incoraggianti nel proseguire lungo questa strada, considerata da molti come l’ultima frontiera nel wound care.
The healing of a chronic wound is an articulated and complex process, requiring a patient’s clinical global vision. However, local treatment of the wound bed is of fundamental importance. More and more now we talk about regenerative medicine as a means to stimulate senescent cells in a chronic skin lesion, particularly through the use of mesenchymal stem cells. Autologous adipose tissue is a source of stem cells and Lipogems® technology makes it possible for its clinical application. In this study we analyze the results obtained with this method that, even with the limits of a not yet substantial number of patients, they are still in encouraging continue along this road, considered by many as the last frontier in wound care.