bluuebunny/crossref_metadata_2025_split huggingface dataset:
The EC-HDA9 complex rhythmically regulates histone acetylation at the TOC1 promoter in Arabidopsis
Authors: Lee Kyounghee , Mas Paloma , Seo Pil Joon 
Published: April 2019

AbstractCircadian clocks are conserved time-keeper mechanisms in some prokaryotes and higher eukaryotes. Chromatin modification is emerging as key regulatory mechanism for refining core clock gene expression. Rhythmic changes in histone marks are closely associated to the TIMING OF CAB EXPRESSION 1 (TOC1) Arabidopsis clock gene. However, the chromatin-related modifiers responsible for these marks remain largely unknown. Here, we uncover that the chromatin modifier HISTONE DEACETYLASE 9 (HDA9) and the Evening complex (EC) component EARLY FLOWERING 3 (ELF3) directly interact to regulate the declining phase of TOC1 after its peak expression. We found that HDA9 specifically binds to the TOC1 promoter through the interaction with ELF3. The EC-HDA9 complex promotes H3 deacetylation at the TOC1 locus, contributing to suppressing TOC1 expression during the night, the time of EC function. Therefore, we have identified the mechanism by which the circadian clock intertwines with chromatin-related components to shape the circadian waveforms of gene expression in Arabidopsis.
Gene expression analysis delineates the potential roles of multiple interferons in systemic lupus erythematosus
Authors: Catalina Michelle D. , Bachali Prathyusha , Geraci Nicholas S. , Grammer Amrie C. , Lipsky Peter E. 
Published: April 2019

AbstractA role for interferon (IFN) in systemic lupus erythematosus (SLE) pathogenesis is inferred from the prominent IFN gene signature (IGS), but the major IFN species and its relationship to disease activity are unknown. A bioinformatic approach employing individual IFN species gene signatures to interrogate SLE microarray datasets demonstrates a putative role for numerous IFN species, with prominent expression of IFNB1 and IFNW signatures. In contrast with other SLE-affected organs, the IGS is less prominent in lupus nephritis. SLE patients with active and inactive disease have readily detectable IGS and the IGS changes synchronously with a monocyte signature but not disease activity, and is significantly related to monocyte transcripts. Monocyte over-expression of three times as many IGS transcripts as T and B cells and IGS retention in monocytes, but not T and B cells from inactive SLE patients contribute to the lack of correlation between the IGS and SLE disease activity.
Boosting the pseudocapacitance of nitrogen-rich carbon nanorod arrays for electrochemical capacitors
Authors: Yang Duo , Song Yu , Ye Yin-Jian , Zhang Mingyue , Sun Xiaoqi , Liu Xiao-Xia 
Published: April 2019

The ultrahigh N content (∼24%) induced by the low-temperature treatment boosts the pseudocapacitance for carbonaceous materials.
Efficacy and toxicities of combination maintenance therapy in the treatment of advanced non-small-cell lung cancer: an up-to-date meta-analysis
Authors: Hu Jianming , Hu Jiawei , Liu Xiaolan , Li Long , Bai Xue 
Published: April 2019

Abstract
Background: Single agent maintenance therapy has been approved for the treatment of advanced non-small-cell lung cancer (NSCLC) due to its potential survival benefits, but whether combined maintenance therapy would improve the survival of advanced NSCLC remains undetermined.
Methods: Relevant trials were identified by searching electronic databases and conference meetings. Prospective randomized controlled trials (RCTs) assessing combination maintenance therapy in advanced NSCLC patients were included. Outcomes of interest included overall survival (OS), progression-free survival (PFS), and grade 3–4 toxicities.
Results: A total of 1950 advanced NSCLC patients received combination maintenance treatment from six trials were included for analysis. The use of doublet maintenance therapy in NSCLC patients significantly improved PFS (HR 0.74, 95%CI: 0.59–0.93, P = 0.010), but not for OS (HR 0.95, 95%CI: 0.85–1.07, P = 0.40) in comparison with single agent maintenance therapy. Similar results were observed in sub-group analysis according to treatment regimens. In addition, there was no significantly risk difference between doublet and single agent maintenance therapy in terms of grade 3/4 hematologic and non-hematologic toxicities.
Conclusion: The findings of the present study show that doublet combination maintenance therapy is superior to single agent maintenance therapy in terms of PFS, without increased grade 3–4 toxicities. Future prospective studies are recommended to clearly assess the long-term clinical benefit of doublet maintenance therapy and its impact on health-related quality of life.
Decentring antibiotics: UK responses to the diseases of intensive pig production (ca. 1925-65)
Authors: Woods Abigail 
Published: April 2019

AbstractIt is widely assumed that the development of antibiotics had a transformative effect on livestock production by making it possible to keep larger numbers of animals in smaller spaces without them succumbing to disease. Using the health and production of UK pigs, ca. 1925-65, as a case study, this article argues that their impact has been overstated. It draws on evidence from veterinary journals, farming magazines, and government-appointed committees to demonstrate the significance of other methods of countering the diseases that emerged in association with intensive production systems. Devised by vets, farmers and other experts, these methods predated antibiotics and evolved alongside them. They were rooted in a shared understanding of pig diseases as highly complex phenomena that resulted from interactions between pig bodies and their environments. Recognition of the roles played by housing, husbandry, nutrition, and pathogens in the production of pig disease suggested multiple possible points of intervention. In situating antibiotics within this landscape of disease prevention and control, this article challenges existing claims about their reception and impact, decentres them from the history of intensive farming, and draws attention to other methods of promoting pig health, which may find renewed applications as we move towards a post-antibiotic era.
Modelling school participation based on the theory of planned behaviour / Modelamiento de la participación escolar basado en la teoría del comportamiento planificado
Authors: Awad-Carrillo Alia , Pérez-Salas Claudia-Paz , Sirlopú David 
Published: April 2019

This study evaluated a predictive model of school participation based on Ajzen’s theory of planned behaviour. Attitudes towards social justice, perceived control and subjective norm on school participation were tested, mediated by the behavioural intention in favour of social justice in a sample of 443 secondary school students. The proposed model showed good fit (χ2 = 597.740, df = 342; RMSEA = .041). The behavioural intentions towards social justice and perceived behavioural control were directly related to school participation. An indirect effect of perceived control on participation was detected, mediated by behavioural intention, but no evidence was found of the indirect effect of either attitude or norm on school participation.
Lupeol suppresses migration and invasion via p38/MAPK and PI3K/Akt signaling pathways in human osteosarcoma U-2 OS cells
Authors: Hsu Ming-Jie , Peng Shu-Fen , Chueh Fu-Shin , Tsai Chang-Hai , Tsai Fuu-Jen , Huang Chih-Yang , Tang Chih-Hsin , Yang Jai-Sing , Hsu Yuan-Man , Huang Wen-Wen , Chung Jing-Gung 
Published: April 2019

ABSTRACT
Lupeol, one of the common components from the fruits and natural foods, has been reported to exert antitumor activities in many human cancer cell lines; however, its effects on osteosarcoma cell metastasis were not elucidated. In the present study, lupeol at 10–25 μM induced cell morphological changes and decreased total viable cell number in U-2 OS cells. Lupeol (5–15 μM) suppressed cell mobility, migration, and invasion by wound healing and transwell chamber assays, respectively. Lupeol inhibited the activities of MMP-2 and −9 in U-2 OS cells by gelatin zymography assay. Lupeol significantly decreased PI3K, pAKT, β-catenin, and increased GSK3β. Furthermore, lupeol decreased the expressions of Ras, p-Raf-1, p-p38, and β-catenin. Lupeol also decreased uPA, MMP-2, MMP-9, and N-cadherin but increased VE-cadherin in U-2 OS cells. Based on these observations, we suggest that lupeol can be used in anti-metastasis of human osteosarcoma cells in the future.
Understanding current-driven dynamics of magnetic Néel walls in heavy metal/ferromagnetic metal/oxide trilayers
Authors: Li Mei , Wang Jianbo , Lu Jie 
Published: April 2019

Abstract
We consider analytically current-driven dynamics of magnetic Néel walls in heavy metal/ferromagnetic metal/oxide trilayers where strong spin–orbit coupling and interfacial Dzyaloshinskii–Moriya interaction (i-DMI) coexist. We show that field-like spin–orbit torque (FL-SOT) with effective field along

n
×

J

ˆ

(n being the interface normal and

J

ˆ

being the charge current direction) and i-DMI induced torque can both lead to Walker breakdown suppression meanwhile leaving the wall mobility (velocity versus current density) unchanged. However, i-DMI itself can not induce the ‘universal absence of Walker breakdown’ (UAWB) while FL-SOT exceeding a certain threshold can. Finitely-enlarged Walker limits before UAWB are theoretically calculated and well explain existing data. In addition, change in wall mobility and even its sign-inversion can be understood only if the anti-damping-like SOT is appended. For Néel walls in ferromagnetic-metal layer with both perpendicular and in-plane anisotropies, we have calculated the respective modifications of wall mobility under the coexistence of spin-transfer torque, SOTs and i-DMI. Analytics shows that in trilayers with perpendicular anisotropy strong enough spin Hall angle and appropriate sign of i-DMI parameter can lead to sign-inversion in wall mobility even under small enough current density, while in those with in-plane anisotropy this only occurs for current density in a specific range.
Realising single-shot measurements of quantum radiation reaction in high-intensity lasers
Authors: Baird C D , Murphy C D , Blackburn T G , Ilderton A , Mangles S P D , Marklund M , Ridgers C P 
Published: April 2019

Abstract
Modern laser technology is now sufficiently advanced that collisions between high-intensity laser pulses and laser-wakefield-accelerated (LWFA) electron beams can reach the strong-field regime, so that it is possible to measure the transition between the classical and quantum regimes of light–matter interactions. However, the energy spectrum of LWFA electron beams can fluctuate significantly from shot to shot, making it difficult to clearly discern quantum effects in radiation reaction (RR), for example. Here we show how this can be accomplished in only a single laser shot. A millimetre-scale pre-collision drift allows the electron beam to expand to a size larger than the laser focal spot and develop a correlation between transverse position and angular divergence. In contrast to previous studies, this means that a measurement of the beam’s energy-divergence spectrum automatically distinguishes components of the beam that hit or miss the laser focal spot and therefore do and do not experience RR.
Robust nonreciprocal acoustic propagation in a compact acoustic circulator empowered by natural convection
Authors: Liu Xingxing , Cai Xiaobing , Guo Qiuquan , Yang Jun 
Published: April 2019

Abstract
The development of the quantum Hall effect in condensed matter physics that breaks time-reversal symmetry by magnetic biasing has inspired its analog in classical nonreciprocal acoustics. Nonreciprocal acoustic propagation is highly desirable to control acoustics in isolation, broadband unidirectional transmission, and topologically robust to structural disorders or defects. So far, these fascinating properties have been investigated through fan-induced moving media, acoustic capacitance adjustment and acoustic metamaterials. However, these may be associated with disadvantages including extra noise and limited dynamic controlling performance. Here we overcome these limitations by introducing heat-induced natural convection into acoustic circulator, and demonstrate that the classical acoustic circulator with thermal management can realize robust nonreciprocal acoustic propagation. The concept of combining heat-induced natural convection and aeroacoustics creates a new practical paradigm and increases the feasibility for nonreciprocal acoustics due to merits of dynamic control, versatile topological structures, and miniaturization in the absence of moving parts.
Quantum interference of multi-photon at beam splitter with application in measurement-device-independent quantum key distribution
Authors: Pradana Andri , Chew Lock Yue 
Published: April 2019

Abstract
Despite the relative simplicity of the traditional Hong–Ou–Mandel (HOM) interferometer setup, it is of fundamental interest in various quantum optics applications and quantum information technologies. In this article, multi-photon interference using the original HOM interferometer setup is analyzed. More specifically, for any photon number state with Gaussian spectral distribution entering the beam splitter, the general analytical solution is calculated. The result is then used to study the coincident probability for coherent sources (laser) and squeezed coherent state. We also look into the potential benefits of implementing the squeezed coherent state in discrete-variable Measurement-Device-Independent Quantum Key Distribution and find that by optimizing the squeezing parameter, the error rate can be significantly reduced. This in turn also enhances the secret key rate performance over the coherent state.
TractaViewer: a genome-wide tool for preliminary assessment of therapeutic target druggability
Authors: Pearson Neil , Malki Karim , Evans David , Vidler Lewis , Ruble Cara , Scherschel James , Eastwood Brian , Collier David A 
Published: April 2019

Abstract

Summary
We present software to characterize and rank potential therapeutic (drug) targets with data from public databases and present it in a user-friendly format. By understanding potential obstacles to drug development through the gathering and understanding of this information, combined with robust approaches to target validation to generate therapeutic hypotheses, this approach may provide high quality targets, leading the process of drug development to become more efficient and cost-effective.

Availability and implementation
The information we gather on potential targets concerns small-molecule druggability (ligandability), suitability for large-molecule approaches (e.g. antibodies) or new modalities (e.g. antisense oligonucleotides, siRNA or PROTAC), feasibility (availability of resources such as assays and biological knowledge) and potential safety risks (adverse tissue-wise expression, deleterious phenotypes). This information can be termed ‘tractability’. We provide visualization tools to understand its components. TractaViewer is available from https://github.com/NeilPearson-Lilly/TractaViewer

Supplementary information
Supplementary data are available at Bioinformatics online.
Multiple peritricuspidal reentry tachycardias after cardiac infiltration by leukaemia: a case report
Authors: Kawamura Iwanari , Fukamizu Seiji , Miyazawa Satoshi , Hojo Rintaro 
Published: April 2019

Abstract

Background
Cardiac involvement by malignant lymphocytic neoplasms is a rare phenomenon. Little is known concerning cardiotoxicity in the chronic phase after completion of treatment.

Case summary
A 50-year-old woman with a past history of cardiac involvement of acute lymphoblastic leukaemia (ALL) underwent electrophysiologic study and catheter ablation for symptomatic atrial tachycardia (AT). She was diagnosed with ALL when she was 8 years old and treated with systematic chemotherapy with prednisolone and vincristine. After complete remission, she suffered from repeated palpitations beginning at the age of 16 years. Electrophysiologic study using high-density (HD) mapping showed two types of peritricuspid AT in addition to low voltage in the right atrium with conduction delay.

Discussion
Cardiac involvement by malignant lymphocytic neoplasms is a rare phenomenon, and cardiac infiltration often disappears after remission of ALL. Thus, little is known about cardiac electrophysiological characteristics in the chronic phase of complete remission of ALL. We describe a rare case of a patient with multiple peritricuspidal reentry tachycardias after cardiac infiltration by leukaemia using a HD mapping system.
Giant unruptured aneurysm of the left coronary sinus of Valsalva presenting as acute coronary syndrome: a case report
Authors: Mørk Sivagowry Rasalingam , Eftekhari Ashkan , Tang Mariann , Klaaborg Kaj-Erik 
Published: April 2019

Abstract

Background
Sinus of Valsalva aneurysm (SVA) is a rare cardiac anomaly that can be congenital or acquired. Unruptured aneurysms may be asymptomatic but can present as malignant arrhythmias, acute chest pain, and even sudden cardiac death. Both ruptured and unruptured SVAs may have fatal complications, thus prompt diagnosis and surgery is critical.

Case summary
We report a successful surgical repair of an unruptured aneurysm of the left sinus of Valsalva presenting as acute coronary syndrome. Coronary angiography (CAG) and cardiac multislice computed tomography (CT) revealed a large unruptured aneurysm of the left sinus of Valsalva. Surgical repair was performed by resection of the aneurysm, aortic valve replacement with composite graft, and coronary artery bypass.

Discussion
Aneurysm of the left sinus of Valsalva is an extremely rare condition. Correct diagnosis can be done by echocardiography, CAG, or CT. Non-ruptured aneurysms should be surgically repaired if they are associated with significant symptoms or if their size enlarge rapidly.
Neighbourhood Ethnic Composition and Social Participation of Young People in England
Authors: Fumagalli Elena , Fumagalli Laura 
Published: April 2019

AbstractWe analyse how neighbourhood ethnic diversity and segregation affect adolescents’ social participation in England. We distinguish between participation in ‘purposeful activities’—such as sports and volunteering—and hanging around with friends. We suggest a novel identification strategy to address the problem of endogeneity of ethnic diversity and segregation. We find that ethnic diversity decreases hanging around, while ethnic segregation increases it. No effects on participation in purposeful activities are found.
Treatment of cardiac transthyretin amyloidosis: an update
Authors: Emdin Michele , Aimo Alberto , Rapezzi Claudio , Fontana Marianna , Perfetto Federico , Seferović Petar M , Barison Andrea , Castiglione Vincenzo , Vergaro Giuseppe , Giannoni Alberto , Passino Claudio , Merlini Giampaolo 
Published: April 2019

Abstract
Transthyretin (TTR) is a tetrameric protein synthesized mostly by the liver. As a result of gene mutations or as an ageing-related phenomenon, TTR molecules may misfold and deposit in the heart and in other organs as amyloid fibrils. Cardiac involvement in TTR-related amyloidosis (ATTR) manifests typically as left ventricular pseudohypertrophy and/or heart failure with preserved ejection fraction. ATTR is an underdiagnosed disorder as well as a crucial determinant of morbidity and mortality, thus justifying the current quest for a safe and effective treatment. Therapies targeting cardiac damage and its direct consequences may yield limited benefit, mostly related to dyspnoea relief through diuretics. For many years, liver or combined heart and liver transplantation have been the only available treatments for patients with mutations causing ATTR, including those with cardiac involvement. The therapeutic options now include several pharmacological agents that inhibit hepatic synthesis of TTR, stabilize the tetramer, or disrupt fibrils. Following the positive results of a phase 3 trial on tafamidis, and preliminary findings on patisiran and inotersen in patients with ATTR-related neuropathy and cardiac involvement, we provide an update on this rapidly evolving field, together with practical recommendations on the management of cardiac involvement.
IncI1 ST3 and IncI1 ST7 plasmids from CTX-M-1-producing Escherichia coli obtained from patients with bloodstream infections are closely related to plasmids from E. coli of animal origin
Authors: Valcek Adam , Roer Louise , Overballe-Petersen Søren , Hansen Frank , Bortolaia Valeria , Leekitcharoenphon Pimlapas , Korsgaard Helle B , Seyfarth Anne Mette , Hendriksen Rene S , Hasman Henrik , Hammerum Anette M 
Published: April 2019

Abstract

Objectives
Fully sequenced IncI1 plasmids obtained from CTX-M-1-producing Escherichia coli of human and animal origin were compared.

Methods
Twelve E. coli isolates sharing identical ESBL genes and plasmid multilocus STs sequenced on Illumina and MinION platforms were obtained from the Danish antimicrobial resistance surveillance programme, DANMAP. After de novo assembly, the sequences of plasmids harbouring blaCTX-M-1 were manually curated and ORFs annotated. Within-group comparisons were performed separately for the IncI1 ST3 plasmid type and the IncI1 ST7 plasmid type. The IncI1 ST3 plasmid group was obtained from 10 E. coli isolates (2 from patients with bloodstream infections, 6 from food and 2 from animals). The IncI1 ST7 plasmids originated from E. coli isolates obtained from a patient with bloodstream infection and from a pig. Sequences of IncI1 ST3 and IncI1 ST7 plasmids harbouring blaCTX-M-1 with determined origin were retrieved from GenBank and used for comparison within the respective group.

Results
The 10 IncI1 ST3 blaCTX-M-1 plasmids were highly similar in structure and organization with only minor plasmid rearrangements and differences in the variable region. The IncI1 ST7 blaCTX-M-1 plasmids also showed high similarity in structure and organization. The high level of similarity was also observed when including plasmids from E. coli of animal origin from Australia, Switzerland, the Netherlands and France.

Conclusions
This study shows broad spread of a very successful CTX-M-1-producing IncI1 type plasmid among E. coli of both human and animal origin.