bluuebunny/crossref_metadata_2025_split huggingface dataset:
Xenon Regeneration by CO2 Removal from Exhaled Anesthetic Gas Mixture by a Hybrid Ultramicroporous Material with Customized Nanotrap
Authors: Nie Hong‐Xiang , Yu Mei‐Hui , Huang Hongliang , Liu Shan‐Shan , Jia Ji‐Zhen , Li Landong , Chang Ze , Zaworotko Michael J. , Bu Xian‐He 
Published: November 2024

AbstractXenon, Xe, is a noble gas that is present in the atmosphere in trace amounts. Nevertheless, despite its low abundance and relatively high cost, Xe has utility, including as an anesthetic and a neuroprotectant in the medical industry. Xe recycling after usage will represent an approach that shall enable more widespread adoption in medicine. In this work, it is reported that the microporous metal‐organic framework (MOF) material NKU‐1017(Si) can enable Xe recycling by capturing CO2 impurities from exhaled anesthetic Xe gas mixtures at ambient temperature for facile and efficient recycling of Xe. The performance of NKU‐1017(Si) is driven by its ultramicroporous structure that offers a high density of aromatic rings on the pore surface along with other functionality to form a bespoke nanotrap for CO2 with multiple C─H…π interaction sites that result in CO2/Xe selectivity of 15.5 at ambient conditions. Whereas NKU‐1017(Si) adsorbs both H2O (300 cm3g−1) and CO2 (70 cm3g−1), humidity does not affect dynamic breakthrough performance. Theoretical studies provide insight into the CO2‐framework binding interactions that drive this performance. The superior separation selectivity of NKU‐1017(Si) under ambient conditions enables a new approach for the Xe recovery through the regeneration of anesthetic gas for more widespread application in medicine.
Giant Topological Hall Effect and Colossal Magnetoresistance in Heusler Ferromagnet near Room Temperature
Authors: Yanda Premakumar , Noohinejad Leila , Mao Ning , Peshcherenko Nikolai , Imasato Kazuki , Srivastava Abhay K. , Guan Yicheng , Giri Bimalesh , Sharma Avdhesh Kumar , Manna Kaustuv , Parkin Stuart S. P. , Zhang Yang , Shekhar Chandra , Felser Claudia 
Published: November 2024

AbstractColossal magnetoresistance (CMR) is an exotic phenomenon that allows for the efficient magnetic control of electrical resistivity and has attracted significant attention in condensed matter due to its potential for memory and spintronic applications. Heusler alloys are the subject of considerable interest in this context due to the electronic properties that result from the nontrivial band topology. Here, the observation of CMR near room temperature is reported in the shape memory Heusler alloy Ni2Mn1.4In0.6, which is attributed to the combined effects of magnetic field‐induced martensite twin variant reorientation (MFIR) and magnetic field‐induced structural phase transformation (MFIPT). This compound undergoes a structural phase transition from a cubic (austenite‐L21) ferromagnetic (FM) to a monoclinic (martensite) antiferromagnetic (AFM), which leads to an effective increase in the size of the Fermi surface and consequently in CMR. Additionally, it exhibits significant anomalous Hall conductivity in both antiferromagnetic and ferromagnetic phases. Furthermore, it demonstrates a giant topological Hall resistivity (THR) ≈6 µΩ.cm in the vicinity of martensite transition due to the enhanced spin chirality resulting from the formation of magnetic domains with Bloch‐type domain walls. The findings contribute to the understanding of the magnetotransport of Ni‐Mn‐In Heusler alloys, which are prospective candidates for room‐temperature spintronic applications.
Molecular Design of a Diketopyrrolopyrrole Conjugated Oligoelectrolyte Capable of Imaging Intracellular Vesicle Membrane Dynamics
Authors: Chan Samuel J. W. , Zhu Ji‐Yu , Yip Benjamin Rui Peng , Shyamasundar Sukanya , Bazan Guillermo C. 
Published: November 2024

AbstractConjugated oligoelectrolytes (COEs) are lipid bilayer spanning optical reporters that hold promise for delineating spatiotemporal changes in subcellular compartments. However, their ability to probe a broader range of biological processes remains restricted due to the lack of environmentally‐responsive chemical functionalities. Herein, the study reports a novel COE, namely COE‐KP, for monitoring spatiotemporal changes in the endolysosomal vesicles. COE‐KP features a central diketopyrrolopyrrole functional group in the optically active conjugated core that confers photophysical properties suitable for bioimaging, in particular responding to the presence of hydrogen bonding functionalities within the hydrophobic domain of the lipid bilayer. COE‐KP can thus discriminate cells in different growth states through two‐photon fluorescence lifetime imaging microscopy (FLIM) with excitation in the NIR‐II range. These changes in lifetime most reasonably reflect the degree of water permeability through the membrane and are not linked to notable differences in membrane tension or solvent polarity. Furthermore, using stimulated emission depletion (STED) nanoscopy, it is possible to directly visualize membrane‐bound COEs within cellular vesicles. These results illustrate further opportunities for applying COE‐based reporters for super‐resolution microscopy of organelle membranes, visualization of subcellular membrane morphologies, and imaging long‐term changes in membrane properties.
Isolation Transformer Based Very Low Frequency Antenna with Enhanced Radiation Characteristics
Authors: Wu Jingqi , Zeng Zilun , Wang Liwei , Xu Jianchun , Bi Ke 
Published: November 2024

AbstractVery low frequency electromagnetic waves adeptly propagate in harsh cross‐medium environments, surmounting the rapid attenuation that impedes high‐frequency counterparts. Traditional low frequency antennas, however, encounter challenges concerning size, efficiency, and power. Here, an isolation transformer based very low frequency loop antenna with compact size and well impedance matching is proposed to enhance radiation characteristics for long‐distance communication. By utilizing the high magnetic permeability amorphous/nanocrystalline alloy Fe73.5Cu1Nb3B9Si13.5, the isolation transformer enables efficient and stable high‐current input. This design surpasses the current limitation of the conventional loop antennas, thereby improving its electromagnetic performance. Consequently, the radiation intensity of proposed antenna can be effectively increased over 30 times compared to traditional loop antennas. According to the experimental measurements, the transmission distance is over 340 m at 15 kHz using a single proposed antenna with a diameter of 2 m. Its robust performance, such as high radiation efficiency, low power consumption, and long‐distance transmission capacity, suggests significant potential for applications in underground communications and underwater information transmission.
Polymeric Multivalent Fc Binding Peptides‐Fabricated Clinical Compounding Bispecific Antibody Potentiates Dual Immunotherapy Targeting PD1 and CTLA‐4
Authors: Liu Zongyu , Chu Hongyu , Zhao Weidong , Yang Chenguang , Liu Tongjun , Shen Na , Tang Zhaohui 
Published: November 2024

AbstractDual Opdivo plus Yervoy immunotherapy, targeting the immune checkpoints PD1 and CTLA‐4, is successful in clinical use. However, it is associated with a high incidence of adverse events, and its therapeutic efficacy needs improving. In this study, polymeric multivalent Fc‐binding peptides (PLG‐Fc‐III‐4C) are employed to fabricate a bispecific antibody (PD1/CTLA‐4 BsAb) to potentiate dual immunotherapy targeting PD1 and CTLA‐4. The PD1/CTLA‐4 BsAb is prepared by mixing PLG‐Fc‐III‐4C with aPD1 and aCTLA‐4 in an aqueous solution for 3 h using the clinically optimal 3:1 proportion of aPD1 to aCTLA‐4. PD1/CTLA‐4 BsAb significantly inhibits tumors in MC38 colon cancer‐bearing mice more effectively than the combination of aPD1 and aCTLA‐4, with tumor suppression rates of 96.8% and 77.3%, respectively. It also induces a higher percentage of CD8+ T cells and increases the secretion of effector cytokines while reducing Treg levels in tumors compared to phosphate‐buffered saline, indicating significant tumor immunity regulation. Mechanistically, a 6.3‐fold increase in PD1/CTLA‐4 BsAb accumulation in tumors due to the tumor targeting ability of aPD1, and the PD1/CTLA‐4 BsAb significantly reduces the adverse colitis event in healthy mice, compared to aPD1 and aCTLA‐4. Thus, these findings provide a novel approach to enhance antitumor therapy using aPD1 and aCTLA‐4.
Cyclic Evolution of Synergized Spin and Orbital Angular Momenta
Authors: Liu Lei , Sun Xiao‐Chen , Tian Yuan , Zhang Xiujuan , Lu Ming‐Hui , Chen Yan‐Feng 
Published: November 2024

AbstractSpin angular momentum (SAM) and orbital angular momentum (OAM) are fundamental physical characteristics described by polarization and spatial degrees of freedom, respectively. Polarization is a feature of vector fields while spatial phase gradient determines the OAM ubiquitous to any scalar field. Common wisdom treats these two degrees of freedom as independent principles to manipulate wave propagations. Here, their synergy is demonstrated. This is achieved by introducing two orthogonal p‐orbitals as eigenbases, whose spatial modal features are exploited to generate OAM, and the associated orbital orientations provide means to simultaneously manipulate polarizations. Through periodic modulation and directional coupling, a full cyclic evolution of synchronized and synergized SAM‐OAM is realized. Remarkably, this evolution acquires a nontrivial geometric phase, leading to its representation on a Möbius strip. Experimentally, an acoustic cavity array is designed, whose dipole resonances precisely mimic the p‐orbitals, with pressure fields featuring the spatial characteristics and velocity fields the vectorial orientations. Based on this synergy, a spin‐orbital‐Hall effect is further showcased, highlighting the intricate locking of handedness, directionality, spin density, and spatial mode profile. This study unveils a fundamental connection between SAM and OAM, promising avenues for their novel applications in trapping, coding, and communications.
Photothermal Synergistic Hydrogen Production via a Fly‐Ash‐made Interfacial Vaporific System
Authors: Xie Yin , Xu Chenyu , Liu Yan , Zhang Entao , Chen Ziying , Zhan Xiaopeng , Deng Guangyu , Gao Yuan , Zhang Yanwei 
Published: November 2024

AbstractEmploying UV–vis spectrum for hydrogen generation and vis‐IR spectrum to elevate reaction temperatures and induce phase transitions effectively enhances yield and purifies water, demonstrating a judicious strategy for solar energy utilization. This study presents an interfacial photothermal water splitting system that utilizes all‐inorganic, economical industrial by‐products known as fly ash cenospheres (FAC) for solar‐driven hydrogen generation. In this system, the yield reaches 254.8 µmol h−1 cm−1, representing an 89% augmentation compared to that of the three‐phase system. In situ experiments, combined with theoretical calculation, reveal the system's robust light absorption capacity, facilitating rapid gas separation, thus improves the solar‐to‐hydrogen (STH) efficiency. Furthermore, the system demonstrates strong performance in turbid water and scalability for expansive applications, achieving a hydrogen yield exceeding 50 L h−1 m−2 from various water sources. Facilitating large‐scale hydrogen production and water purification, it thereby establishing its potential as a viable solution for sustainable energy generation.
Corneal Mucin‐Targeting Liposome Nanoplatforms Enable Effective Treatment of Dry Eye Diseases by Integrated Regulation of Ferroptosis and Inflammation
Authors: Zhang Yin , Zhou Tinglian , Wang Kai , Luo Chenqi , Chen Dan , Lv Zeen , Han Haijie , Yao Ke 
Published: November 2024

AbstractThe incidence of dry eye disease (DED) has been increasing annually worldwide, creating an urgent need for new therapies. Due to the multifactorial mechanism underlying DED, traditional medications focused on decreasing ocular surface inflammation have been unable to address all the harmful factors and fail to achieve a complete clinical cure. Ferroptosis, a new form of programmed cell death characterized by lipid peroxidation, has become a pivotal contributor to dry eye oxidative stress‐driven pathology. Therefore, therapeutic targeting of ferroptosis may be an attractive option for dry eye management. Herein, a sialic acid‐targeting peptide‐modified liposome loaded with Cyclosporine A (CsA), a typical anti‐inflammatory drug, and Ferrostatin‐1 (Fer‐1), a selective ferroptosis inhibitor, is developed termed as CF@SNPs, for combing and sustaining DED treatment. This multifunctional liposomal encapsulation demonstrates excellent aqueous solubility; moreover, the sialic acid‐targeting peptide prolongs ocular surface retention, further enhancing therapeutic efficacy. The CF@SNPs treatment comprehensively alleviates DED symptoms, including improving corneal defects, augmenting goblet cell count, and restoring tear secretion. Specifically, CF@SNPs attenuate dry eye pathology by suppressing p53‐SLC7A11‐GSH‐dependent ferroptosis and TNF‐α‐associated inflammatory cascades, accompanied by favorable biocompatibility in vivo. These results underscore the promising potential of this superior nano‐formulation for DED pharmacotherapy.
Soil depth distribution of particulate organic carbon and nitrogen in the southeastern United States
Authors: Franzluebbers Alan J. 
Published: November 2024

AbstractParticulate organic matter may be an important component feeding soil microbial activity. This study described population‐level statistics of particulate organic carbon (C) and nitrogen (N) in predominately Ultisols across 181 farms throughout North Carolina, Virginia, and Georgia. Soil profiles were sampled under conventional‐till cropland (n = 186), no‐till cropland (n = 127), grassland (n = 322), and woodland (n = 171). Particulate organic C (g C kg−1 soil) varied from 2.0 to 18.0 (5% to 95% distribution) at 0‐ to 10‐cm depth, 0.4 to 3.9 at 10‐ to 30‐cm depth, and 0.1 to 1.9 at 30‐ to 60‐cm depth. As a proportion of total N, particulate organic N was 0.26 ± 0.10, 0.12 ± 0.09, and 0.08 ± 0.08 kg kg−1 at 0‐ to 10‐, 10‐ to 30‐, and 30‐ to 60‐cm depths, respectively. Particulate organic C was most dramatically affected at 0‐ to 10‐cm depth, following the order: conventional‐till cropland < no‐till cropland < grassland < woodland. Particulate organic N followed a similar order, except there was no difference between grassland and woodland. Particulate organic matter brings vitality to soil along a trajectory toward greater organic matter.
Economic potential of industrial hemp in Oregon: An ex ante minimum‐data assessment
Authors: Antle John M. , Cho Seojin 
Published: November 2024

AbstractThis paper provides an ex ante evaluation of the economic potential of the emergent industrial hemp industry in Oregon, a state with conditions favorable to hemp cultivation. The analysis exploits available data to simulate the performance of hemp for fiber and oil in existing cropping systems. The study finds that profitability and adoption of hemp into existing crop production systems in Oregon could range widely, depending on key factors including hemp prices, costs of production, investments in production technology and supply chains, and policies affecting hemp production and utilization.
dP/dtmax: An underestimated prognostic factor in large animal infarction model
Authors: Garamvölgyi Rita , Kőrösi Dénes , Tátrai Ottó , Bodor Emőke , Fajtai Dániel , Farkas Kornélia , Vorobcsuk András 
Published: November 2024

AbstractThe present study aims to establish a reproducible large animal experimental unit using a minipig model to monitor cardiac function changes. A 90‐min closed‐chest balloon occlusion of the left anterior descending branch of the coronary artery was used to induce myocardial infarction in Pannon minipigs. To monitor the cardiac function, measurements were made by cardiac magnetic resonance imaging (cMRI), invasive pressure monitoring, and a Pulse index Continuous Cardiac Output (PiCCO) hemodynamic system at 0, 72, and 720 h during the follow‐up period. End‐diastolic and end‐systolic volumes (EDV, ESV), left ventricular ejection fraction (LVEF) obtained by cMRI evaluation, global ejection fraction and aortic dP/dtmax obtained by the invasive method, were recorded and compared. The 72‐ and 720‐h EDV data showed a significant increase (p = 0.012, <0.001) compared to baseline, and the Day 30 data showed a significant increase compared to Day 3 (p = 0.022). The ESV 72 h after the infarction showed a significant increase (p = 0.001) compared to baseline, which did not change significantly by Day 30 (p = 0.781) compared to Day 3. EDV and ESV were significantly negatively correlated with aortic dpmax, and ESV was significantly correlated with LVEF. For LVEF and dPmax, a significant (p < 0.001 and p = 0.002) worsening was demonstrated at Day 3 compared to baseline, which was no longer statistically detectable for LVEF at Day 30 (p = 0.141), while the difference for dPmax was maintained (p = 0.002). The complementary use of PiCCO hemodynamic measurements in large animal models makes the previously used methodologies more robust and reliable.
The effect of ICU diary on psychiatric symptoms after ICU discharge among adult critically ill patients: A prospective comparative study
Authors: Shibata Mami , Miyamoto Kyohei , Shima Nozomu , Nakashima Tsuyoshi , Fukushima Junichi , Yamada Shinichi , Kimoto Sohei , Inoue Shigeaki 
Published: November 2024

AbstractAimPsychiatric problems are common in critically ill patients after discharge from an intensive care unit (ICU). The effect of intensive care unit (ICU) diaries on psychiatric symptoms after ICU discharge was investigated in this prospective study.MethodsEnrolled were critically ill adult patients who were emergently admitted to an ICU and expected to stay for at least 2 days. These patients received ICU diaries filled out by healthcare professionals and family members. Comparison was made with a historical cohort from a previous trial conducted in the same ICU but without ICU diaries. The primary outcome was the presence of significant post‐traumatic stress disorder (PTSD) symptoms 3 months after ICU discharge. Secondary outcomes included significant symptoms of anxiety and depression.ResultsAmong 61 patients with ICU diaries, questionnaires were sent to 44 patients 3 months after ICU discharge; 29 patients responded and were analyzed (ICU diary group). Seventy‐four patients from a historical cohort were used as a control group. The proportion of patients with significant PTSD symptoms was 19% in the ICU diary group and 16% in the control group (adjusted odds ratio [aOR] [95% confidence interval: 95% CI]: 0.98 [0.26–3.70]). For anxiety and depression, the proportions were 25% and 29% in the ICU diary group, and 38% and 45% in the control group (aOR [95% CI]: 0.46 [0.15–1.38] for anxiety, aOR [95% CI] 0.40 [0.14–1.16] for depression).ConclusionICU diaries were not associated with a reduced incidence of PTSD symptoms 3 months after ICU discharge.
Unveiling the Clinical and Imaging Signatures of Intravascular Lymphoma of the Central Nervous System: A Multicentric Cohort Study
Authors: Berthet Elodie , Guillonnet Antoine , Houillier Caroline , Ursu Renata , Soussain Carole , Touat Mehdi , Gueguen Antoine , de Renzis Benoît , Bigaut Kevin , Ahle Guido , Durozard Pierre , Grosset‐Janin Deborah , Oberic Lucie , Bonnet Antoine , Grandjean Anne‐Pascale , Moluçon‐Chabrot Cécile , Hoang‐Xuan Khê , Chabriat Hugues , Guey Stéphanie 
Published: November 2024

ObjectiveIntravascular lymphoma is a rare subtype of B‐cell lymphoma characterized by a clonal proliferation restricted to the lumen of small vessels. Over 50% of patients exhibit central nervous system (CNS) involvement, but diagnosis is often delayed due to the lack of distinctive features. We aimed to identify key phenotypic features for early diagnosis of intravascular lymphoma with CNS involvement through an in‐depth cohort study.MethodsWe built up a multicenter retrospective cohort of 17 patients recruited in collaboration with the French Expert Network for Oculo‐Cerebral Lymphomas (LOC network), and retrospectively analyzed data from medical records.ResultsIn this cohort, 15 of 17 (88%) patients developed focal neurological episodes, often fluctuating and/or recurrent, with a sudden onset in 68% of episodes, suggesting a vascular origin. Rapid cognitive deterioration occurred in 15 of 17 (88%) patients, psychiatric manifestations in 8 of 17 (47%), and “B signs” in 14 of 17 (82%). Brain MRI showed polymorphic FLAIR hyperintensities in 14 of 16 (87%) patients, and DWI‐positive lesions in 13 of 16 (81%) of patients, which accumulated over time and had unusual characteristics for ischemic lesions (progressive growth, persistent DWI‐hyperintensity over 1 month, surrounded by a wider FLAIR hyperintensity). Early‐onset inflammatory syndrome, and elevated lactate dehydrogenase (LDH) levels were observed in over 90% of cases. Mild and inconsistent meningitis contrasted with a nearly‐constant hyperproteinorachia. An increased interleukin 10/6 ratio over 0,7 was found in 4 of 7 (57%) patients, and skin biopsy led to a pathological diagnosis in 3 of 6 (50%) patients.InterpretationThe results of this study highlight “red flags” that could help accelerate the diagnosis of intravascular lymphoma involving the CNS. ANN NEUROL 2025;97:435–448
Intratumoral Transforming Boron Nanosensitizers for Amplified Boron Neutron Capture Therapy
Authors: Li Liping , Wang Mixue , Zhao Qian , Bai Peirong , Hao Haotian , Zhang Zizhu , Liu Tong , Yang Yongzhen , Pu Kanyi , Zhang Ruiping 
Published: November 2024

AbstractBoron neutron capture therapy (BNCT) is an advanced binary tumor‐cell‐selected heavy‐particle radiotherapy used for treating invasive malignant tumors. However, its clinical applications have been impeded by the rapid metabolism and insufficient tumor‐specific accumulation of boron agents. To tackle this issue, we develop a smart boron nanosensitizer (BATBN) capable of transforming its size in response to cancer biomarker for optimal balance between penetration and retention of boron‐10 for BNCT. BATBN comprises an ultrasmall boron quantum dots (BQD) core (4 nm) conjugated with cell‐penetrating peptides, which facilitates its cellular uptake and deep tumor penetration. In the tumor microenvironment, the tumor biomarker can specifically initiate a self‐condensation reaction of BATBN, leading to the formation of larger‐sized nanoaggregates. Due to such a specific intratumoral transformation, BATBN demonstrates a 2.4‐fold increase in intratumoral boron concentration and a 5.0‐fold increase in tumor retention time compared to the BQDs. Thus, the tumor volume of the BATBNs‐treatment group is 2.7‐fold smaller than that of BQDs in preclinical tumor models after 21 days of neutron irradiation treatment. This study presents a supramolecular strategy to endow BNCT agents with the biomarker‐activated size interconversion, permitting precise and efficient BNCT for cancer treatment.