bluuebunny/crossref_metadata_2025_split huggingface dataset:
Crianças e processos de significação em movimentos de guarda
Authors: De Medeiros Andréa Borges 
Published: September 2019

Este texto tem como propósito refletir sobre movimentos de guarda que geraram um arquivo de práticas numa escola pública do interior de Minas Gerais, envolvendo a equipe escolar bem como crianças e adolescentes. Trata-se de um fragmento de uma tese de doutorado, que teve como foco compreender modos de narrar e de lembrar das crianças quando em contato com práticas vivenciadas na escola. Buscando inspiração na poética barrosiana, a condição do objeto como um inutensílio, foi tomada na relação com aqueles preservados nos espaços de musealização, quando da afirmação de Mário Chagas de que cada observador pesquisa, pergunta e procura depreender dos objetos, pistas que podem indicar vínculos de pertencimentos, bem como singulares processos de rememoração.
DISTRIBUIÇÃO E CONTEXTO GEOLÓGICO-GEOMORFOLÓGICO DA BAUXITA NA REGIÃO DE ESPERA FELIZ, SUL DA SERRA DO CAPARAÓ, MG/ES
Authors: Da Silva Fabricio Sousa , De Oliveira Fabio Soares , Souza Filho Carlos Roberto 
Published: September 2019

Este estudo objetivou identificar e caracterizar o contexto geológico-geomorfólogico das ocorrências de bauxita no sul da Serra do Caparaó, entre os estados de Minas Gerais e Espírito Santo, a partir de dados de espectroscopia de reflectância, difração de raios-X e imagens multiespectrais do sensor Aster. A difração de raios-X evidenciou a presença de gibbsita, caulinita, hematita, goethita e quartzo na bauxita. Espécies minerais equivalentes também foram determinadas a partir da interpretação espectro-mineralógica. A reflectância espectral demonstrou a existência de um nível de degradação diferenciado entre as amostras. A degradação sugere a transformação das condições ambientais (sobretudo bioclimáticas). Foram utilizadas cinco assinaturas espectrais obtidas em laboratório a partir de amostras de bauxita para classificação espectral da imagem ASTER com o classificador Spectral Angler Mapper (SAM). Os resultados mostram a distribuição da bauxita em todos os compartimentos geológicos da região. Trabalhos de campo, entretanto, indicam a existência de inconsistências e falsos-positivos. A principal inconsistência está relacionada à presença de bauxita associada aos paragnaisses do Grupo Andrelândia, que sugere não ter sido a principal rocha formadora de bauxita. A maior parte das ocorrências está ligada às rochas da Suíte Caparaó e em posições da paisagem que reiteram a existência de uma paleo-superfície bauxitizada, desnivelada topograficamente.
DATAÇÃO POR LUMINESCÊNCIA OPTICAMENTE ESTIMULADA (LOE) NAS CRISTAS DE PRAIA DO DELTA DO RIO PARAÍBA DO SUL (RJ): CONSIDERAÇÕES SOBRE A EVOLUÇÃO GEOMORFOLÓGICA ENTRE O PLEISTOCENO SUPERIOR E O HOLOCENO
Authors: Da Rocha Thais Baptista , De Vasconcelos Sérgio Cadena , Pereira Thiago Gonçalves , Fernandez Guilherme Borges 
Published: September 2019

As cristas de praia são feições arenosas construídas pela ação das ondas que marcam posições pretéritas da linha de costa, em função de flutuações no nível do mar e condições de aporte sedimentar, sendo comumente encontradas nas áreas de influência de deltas dominados por ondas. Recentemente elas têm sido datadas pelo método da Luminescência Opticamente Estimulada (LOE), o que tem permitido a reconstrução paleogeográfica de planícies costeiras durante o Quaternário. Além disso, essas cristas também podem ser utilizadas como paleoindicadores de variações do nível do mar. No delta do rio Paraíba do Sul (RJ), os principais modelos de evolução geomorfológica foram construídos a partir de idades obtidas por radiocarbono, cujas cristas de praia nem sempre fornecem materiais para a datação. Nesse sentido, o objetivo do presente trabalho é investigar a geocronologia das cristas de praia do delta do rio Paraíba do Sul, a partir do método da LOE. Foram coletadas 11 amostras no flanco norte do delta, e 10 amostras no flanco sul. Todas as amostras foram analisadas a partir do Protocolo SAR, com 15 alíquotas cada. Os resultados corroboraram muitas discussões anteriormente debatidas, a partir de idades estabelecidas por radiocarbano. Porém, os novos resultados de idades LOE estabelecidos diretamente a partir das cristas de praia levantaram novas questões acerca da evolução do delta. No flanco norte, a idade N3 (4.130 ± 580 anos) marca o início da progradação da planície, como resposta ao aporte sedimentar do rio Paraíba do Sul e a diminuição do nível relativo do mar após o Máximo Transgressivo do Holoceno. Os dados geomorfológicos e topográficos mostram que essa progradação foi gerada a partir de regressão forçada. As idades N1 (38.650±3.170 anos) e N2 (9.400±1.300 anos) mostram que o Pleistoceno Superior e a transição entre o Pleistoceno/Holoceno precisam ser melhor investigados. No flanco sul, a datação nas cristas próximas aos truncamentos erosivos sugere que os ciclos erosivos ou de interrupção da progradação podem ultrapassar um século. As estimativas das taxas de progradação mostram que as taxas foram mais rápidas no flanco sul do que o flanco norte, apresentando cerca de 5,0 m/ano e 3,0 m/ano, respectivamente. Esse resultado sugere a possibilidade de uma segunda fonte sedimentar, além do rio Paraíba do Sul, responsável pela construção da planície no flanco sul.
Lista anotada de Bombicóideos (Lepidoptera:Bombycoidea) del Parque Nacional Natural Utría, Colombia
Authors: Prada Lara Liliana , Correa-Carmona Yenny , Clavijo Giraldo Alejandra , Vargas Sergio Andrés , Parrales Dumar Ariel 
Published: September 2019

Se presenta una lista anotada de especies de las familias Bombycidae, Saturniidae y Sphingidae recolectadas en el Parque Nacional Natural Utría, Chocó, Colombia. El muestreo se realizó en cuatro hábitats del parque durante 31 días, utilizando una trampa de luz con un bombillo de vapor de mercurio. Se registraron 35 especies: 19 Saturniidae, 15 Sphingidae y 1 Bombycidae. Por primera vez para el departamento del Chocó se registran 18 especies. Se resaltan los registros de las especies Syssphinx chocoensis, endémica del Chocó colombiano, Manduca dalica dalica depositada por primera vez en una colección colombiana y el quinto instar de Isognathus scyron. El número de individuos recolectados concuerda con la hipótesis de la fobia lunar. El presente trabajo es la primera aproximación a la diversidad de estas familias para el Parque Nacional Natural Utría.
Madurez de procesos en pequeñas empresas manufactureras de México
Authors: Carballo-Mendívil Blanca , Arellano-González Alejandro , Ríos-Vázquez Nidia Josefina 
Published: September 2019

Rev.esc.adm.neg
Se presentan los resultados de un proyecto cuyo objetivo fue realizar un diagnóstico de procesos con enfoque de madurez, de pequeñas empresas manufactureras en México, con la intención de obtener datos de su situación actual como insumo para el futuro planteamiento de propuestas de mejora.
En este artículo se muestra una síntesis de la literatura relacionada al tema de madurez organizacional, donde se detecta que son pocos los modelos aplicables a este tipo empresas, y menores aún aquellos con enfoque adecuado para el diagnóstico de procesos, por lo que se utilizó el modelo de la Arquitectura del Desempeño Organizacional en una Cadena de Suministro (ADOCS), el cual establece doce procesos organizacionales agrupados en cuatro categorías, y se diseñan instrumentos en formato de rúbrica para identificar el nivel de cumplimiento de cada proceso con respecto a ideales establecidos a partir de modelos teóricos, calculando el nivel de madurez alcanzado de los cuatro propuestos.
Los hallazgos muestran que la mayoría de estas empresas operan con un nivel de madurez artesanal, lo cual indica que se tiene conocimiento general sobre el enfoque de mejora continua, pero no se han formalizado ni sistematizado los procesos, aunque si se implementan esporádicamente mejoras con un enfoque correctivo.
NDRG2 combined with EGFR improved its prognostic value for lung adenocarcinoma
Authors: Yang Bo , Li Xiao-Ping , Zhou Hong-Gang , Jiang Tao , Xiao Ting , Wei Yu-Li , Zhang Liang , Wang Wen-Chen , Zhang Wei-Dong 
Published: September 2019

Abstract
Background N-Myc downstream-regulated gene2 (NDRG2) plays an important role in lung adenocarcinoma (LUAD). Epidermal growth factor receptor (EGFR) mutation has significantly improved prognosis in patients with adenocarcinoma. We aimed to elucidate the clinical value of NDRG2/EGFR as a prediction of prognosis in patients with lung adenocarcinoma.Materials and Methods Immunohistochemistry and western blot analysis were conducted to detect the expression of NDRG2 protein. Association between NDRG2/EGFR expression and clinicopathological parameters of the patients were examined. Serum Carcinoembryonic antigen (CEA) level was examined prior to treatment in patients with LUAD. Patients’ survival rate was assessed by Kaplan–Meier. Candidates for independent prognostic biomarkers were analyzed using a COX proportional hazard model.Results NDRG2 levels were significantly decreased in patients with lung adenocarcinoma. NDRG2 levels were positively correlated with CEA and EGFR. Advanced stages were significantly associated with low expression of NDRG2. Patients with NDRG2-high combined with EGFR-positive expression had the best prognosis during the 5-year follow-up period. Meanwhile, COX regression analysis showed that the conjoined expressions of NDRG2-low/EGFR-positive, NDRG2-high/EGFR-positive and vascular invasion were independent prognostic indicators for lung adenocarcinoma.Conclusion NDRG2 is of more prognosis value as the biomarker for lung adenocarcinoma when analyzed combined with the EGFR expression.
MDR1 polymorphisms are not related to Xeliri and Xelox chemoresistance in colorectal cancer
Authors: Al-Ghafari Ayat B. , Alqahtani Areej M. , Alturki Suzan N. , Doghaither Huda Abdulaziz Al , Tashkandi Hanaa M. , Abusanad Atlal M. , Alkhayyat Shadi S. , Omar Ulfat M. , Zeeneldin Ahmed A. 
Published: September 2019

Abstract
Background Multidrug resistance member 1 (MDR1) is located on chromosome 7 and encodes P-glycoprotein (Pgp), which is universally accepted as a drug resistance biomarker. MDR1 polymorphisms may change either the protein expression or function, suggesting its possible association with cancers, including colorectal cancer (CRC). Thus, this study aimed to determine the effects of MDR1 polymorphisms on the drug response of Saudi CRC patients.Methods DNA samples were obtained from 62 CRC patients and 100 healthy controls. The genotypes and allele frequencies of the MDR1 polymorphisms G2677T and T1236C were determined by polymerase chain reaction–restriction fragment length polymorphism (PCR-RFLP).Results No significant difference was observed in the genotype distribution and allele frequency of T1236C between the CRC the patients and the controls. However, G2677T was found to play a highly significant protective role against the progression of CRC. Moreover, the results showed that none of the genotypes in SNPs T1236C and G2677T affected chemoresistance to Xeliri and Xelox.Conclusions T1236C in the MDR1 gene is not related to CRC risk, and G2677T protects against the development of CRC. Both MDR1 polymorphisms are not associated with the risk of chemoresistance.
Maintenance phototherapy for the treatment of early stage mycosis fungoides
Authors: Gara Soumaya , Litaiem Noureddine , Bacha Takwa , OUEDRAOGO Djamila Sandra , Jmour Yosra , Zeglaoui Faten 
Published: September 2019

Abstract
Background : Phototherapy has been a mainstay of treatment of early stages (Ia-IIa) of mycosis fungoides (MF). Despite this, there is no internationally standardized phototherapy regimen schedule for MF. Efficacy of maintenance therapy is poorly evaluated especially in patients with dark phototype (IV-VI). Methods : Thirty patients with early stage MF treated with PUVA therapy and narrowband UVB therapy from January 2004 to January 2016 at a single institution were retrospectively reviewed. Recurrence rate and recurrence-free survival were assessed in patients who received maintenance phase and in those who underwent follow-up. Results : Seventeen patients had patch stage disease while 16 patients had plaque stage disease. Most of the patients (22, 73%) had dark phototype. Nineteen patients received NB-UVB therapy, while 11 patients received PUVA. Mean follow-up period was 36,1 + 13 months. There was no significant association between the recurrence rate and recurrence free survival in patients who received maintenance phase and those who underwent follow-up. Conclusions: Phototherapy is a safe and effective treatment option for patients with early stage MF. Evidence supporting the use of maintenance phase for the treatment of early stages MF is lacking.
Tibetan wild asses (Equus Kiang) were superior to domestic donkeys (Equus Asinus) in terms of the composition and function of gut microbial community
Authors: Liu Hongjin , Zhao Xinquan , Xu Shixiao , Zhao Liang , Hu Linyong , Xu Tianwei , Zhao Na , Zhang Xiaoling , Li Qi , Chen Dongdong , He Fuquan , Chen Xin 
Published: September 2019

Abstract
Background: Tibetan wild asses are the only wild species of perissodactyls on the Qinghai-Tibetan Plateau, and appears on the International Union for Conversation of Nature (IUCN) 2012 Red List of threatened species. The gut microbiota has a great effect on the health and nutrition of the host, however, scant research is available on the characteristics of their intestinal microbiota. Therefor, understanding the gut microbita composition and function of TWAs can provide a theoretical for the situ conservation of wild animals in the future. Results: To characterize its composition and function, we analyzed the intestinal microbiota of wild asses and domestic donkeys by high-throughput sequencing of the 16s rDNA regions. No significant difference in alpha diversity was detected between these two groups. Beta diversity showed that the bacterial community structure of wild asses was acutely different from domestic donkeys. At the phylum level, the two dominant phyla of Bacteroidetes and Firmcutes in wild asses were significantly higher than that in domestic donkeys. At the genus level, Ruminococcaceae_NK4A214 , Phascolarctobacterium , Coprostanoligenes_group , Lachnospiraceae_XPB1014_group and Akkermansia in wild asses were significantly higher than domestic donkeys. Moreover, statistical comparisons showed that 40 different metabolic pathways exhibited significant differences . Among them, 29 pathways had richer concentrations in wild asses than domestic donkeys, mainly amino acid metabolism, carbohydrate metabolism, and energy metabolism. Of note, network analysis showed that wild asses harbored a relatively more complex bacterial network than domestic donkeys, possibly reflecting the specific niche adaption of gut bacterial communities through species interactions. Conclusions: Wild asses were superior to that of domestic in gut microbial community composition and function. For wild animal conservation, wild asses are more suitable to survive in wild than to be domesticated or captive. Key words: Tibetan wild asses, domestic donkeys, 16S ribosomal RNA gene, gut microbiota
MMP-9 contributes to glomerulosclerosis by causing profibrotic changes in podocytes and glomerular endothelial cells
Authors: Qiao Xi , Guo Jianhong , Loron M , Liu Lixin , Rao Padmashree , Zhao Ye , Cao Qi , Wang Yiping , Wang Yuan Min , Lee Vincent VW , Alexander Stephen I , Harris David CH , Zheng Guoping 
Published: September 2019

Abstract
Background Glomerulosclerosis is characterized by progressive (myo)fibroblast accumulation and collagen deposition involving profibrotic changes of podocytes and endothelial cells. A profibrotic role of MMP-9 in interstitial fibrosis has been reported. Whether MMP-9 plays a role in glomerulosclerosis is not clear yet. Methods A mouse glomerulosclerosis model [adriamycin nephropathy (AN)] was produced in MMP-9-/- and wild-type control BALB/c mice. All animals were sacrificed at 4 weeks after injection. Albuminuria (albumin to creatinine ratio) and calculated GFR were measured. Gomori Trichrome (GT) and Sirius Red (SR) staining were used for assessment of glomerular fibrosis. Profibrotic changes of podocytes or glomerular endothelial cells were examined by confocal microscopy using immunofluorescence staining (IF) of desmin or α-SMA with P-cadherin or VE-cadherin. Results Albuminuria was reduced while GFR was increased in MMP-9-/- AN mice compared with those of wild-type mice. Confocal microscopy showed a significant decrease in podocytes double-stained with P-cadherin and desmin and decrease in glomerular endothelial cell co-staining with VE-cadherin and α-SMA, demonstrating that MMP9-/- AN mice were protected from profibrotic changes in podocytes and glomerular endothelial cells. Glomerulosclerosis was significantly reduced in MMP-9-/- AN mice compared to that of WT, as demonstrated by GT and SR staining. Conclusions MMP-9 contributes to profibrotic changes in podocytes and glomerular endothelial cells and thereby glomerulosclerosis.
Gingivitis in Mice and the Role of Angiogenesis
Authors: Saghiri Mohammad Ali , Moghadam Mona Momeni , Fakharzadeh Amir , Morgano Steven M , Asatourian Armen , Sheibani Nader 
Published: September 2019

Abstract
Background Gingivitis is the first step in an abnormal oral condition, which degrades connective tissue and eventually converts to periodontal diseases leading to alveolar bone and tooth loss. Thrombospondin-1 (TSP1) and Bcl-2 are key regulators of angiogenesis. The transition from gingivitis into periodontitis has four stages and disease progression depends very heavily on changes to the surrounding vasculature structures. We hypothesized that vascular dysfunction plays an important role in the progression of gingivitis. Here we have measured Gingival Crevicular Fluid (GCF) levels in TSP1 and Bcl-2-deficient mice, in which vascular structures are affected, while also looking at the roles that age and gender play in this process. Methods Thirty mice (15 males and 15 females) were divided into three groups of ten (n=10): group A (WT), group B (TSP1 -/-), and group C (Bcl-2 -/-) were subjected to collection of Gingival Crevicular Fluid (GCF). Saliva was collected from different groups of mice after subcutaneous injection of pilocarpine. For the WT group, GCF was monitored for 3, 4, 5 and 6 weeks and the contribution of age was also considered. RESULTS: Samples from Bcl-2 -/- mice showed significantly lower levels of GCF and salivary secretions, while TSP1-/- mice were larger and secreted more saliva. Moreover, the TSP1-/- mice GCF level was significantly higher than that of both the WT and Bcl-2 -/- mice. CONCLUSIONS: The absence of Bcl-2 and TSP1 significantly affects the amount of GCF flow in mice. This current study confirms the important role that alteration of pro- and anti-angiogenic factors can play in the progression of gingivitis and in the amount of salivary secretions. Thus, this type of modulation of angiogenic proteins provides a great opportunity and a novel platform for developing enhanced oral care products of the future. TSP1 showed significantly more saliva secretion, and a larger volume of periodontal pocket. This means that higher level saliva secretion can affect periodontal pocket volume and eventually oral hygiene.
Yarning about oral health: perceptions of urban Australian Aboriginal and Torres Strait Islander Women
Authors: Butten Kaley , Johnson Newell W. , Hall Kerry K. , Toombs Maree , King Neil , O’Grady Kerry-Ann F. 
Published: September 2019

Abstract
Background: Many factors influence how a person experiences oral health and how such experiences may facilitate supportive oral health behaviours. Women in particular face different challenges due to their environment, responsibilities and physiological differences to men. Within Australia, Aboriginal and Torres Strait Islander women are reported to have poorer oral health and are faced with additional barriers to supporting their oral health compared with non-Indigenous women. The objective of this paper is to report the experiences and perceptions of oral health from the perspective of urban, Aboriginal and Torres Strait Islander women. Methods: The present data derive from a descriptive study that used yarning circles and face-to-face interviews with women who were mothers/carers of urban, Aboriginal and/or Torres Strait Islander children. This was a qualitative study to investigate the impact of child oral health on families. Participants used the opportunity to share their own personal experiences of oral health as women, thus providing data for the present analyses. Information collected was transcribed and analysed thematically Results: 20 women shared their personal narratives on the topic of oral health which were reflective of different time points in their life: growing up, as an adult and as a mother/carer. Although women are trying to support their oral health across their life-course, they face a number of barriers, including a lack of information and the costs of accessing dental care. The teenage years and pregnancy were reported as important time periods for oral health support. Conclusions: To improve the oral health of Indigenous Australian women, policymakers must consider the barriers reported by women and critically review current oral health information and services. Current oral health services are financially out of reach for Indigenous Australian women and there is not sufficient or appropriate, oral information across the life-course.
Have our strictures changed? Analysis of Current Characteristics and Management of Urethral Stricture Disease in Zaria, Nigeria
Authors: Oyelowo Nasir , Ahmed Muhammed , Bello Ahmad , Lawal Ahmad Tijani , Maitama Husseni Yusuf , Muhammad Muhammad Salihu , Abdulsalam Khalifa , Bilyaminu lawal Bola , Olagunju Jemila 
Published: September 2019

Abstract
Introduction:
Urethral stricture is a common cause of lower urinary tract symptoms in the middle aged and elderly men. Its presentation and management is closely linked with its etiology and this varies across geographical regions of the world as well as over time.
We hereby review the etiology, characteristics and presentation of men with urethral strictures in a tertiary hospital in northern Nigeria over a year and compare it with previous studies in the region.
Patients and Methods
The study was a prospective study from January-December 2016, all patients with urethral strictures and who consented to the study were enrolled into the study. Data was collected using a structured study profoma and analyzed using SPSS version 23.
Results
The mean age was 44.1 years with a range of 13-71 years. The bulbar urethra was the site of most strictures with a frequency of 65%. The etiology was infection in majority of the patients with a frequency of 53.3%. Post traumatic strictures occurred in 33.3% while iatrogenic and catheter –Induced strictures were seen in 7.1% and 6% respectively. 88% had no previous intervention for the stricture prior to presentation.The complications from urethral strictures observed in the patients were acute urinary retention in 83.4% urethrocutaneous fistulae in 2.4% and urosepsis in 1.2% of the patients. 11% presented with no complication.68% of these patients were managed by excision and end to end anastomosis, 15 % had a penile pedicled flap 12% , a buccal mucosa graft urethroplasty and 5% with staged urethroplasty
The trends in etiology of urethral stricture disease in the region reported is: Ahmed etal in zaria (1990) Infection accounted for 66.50% , post traumatic stricture 31.50%. Ntia et al Sokoto (2006)found infection as aetiology in 44.70% and post-traumatic strictures in 47.40%. Ofoha et al in Jos however found Infection in 53.30% and post traumatic 40.30%
Conclusion
Though there is a gradual rise in post-traumatic and iatrogenic strictures in our environment, Post inflammatory strictures still predominates. It is however infrequently accompanied by fistulae as seen decades ago. These strictures are mostly long segments single bulbar strictures