bluuebunny/crossref_metadata_2025_split huggingface dataset:
Elevated expression of miR‐21 and miR‐155 in peripheral blood mononuclear cells as potential biomarkers for lupus nephritis
Authors: Khoshmirsafa Majid , Kianmehr Nahid , Falak Reza , Mowla Seyed Javad , Seif Farhad , Mirzaei Behnaz , Valizadeh Mohadeseh , Shekarabi Mehdi 
Published: November 2018

AbstractAimLupus nephritis (LN) is a severe complication of systemic lupus erythematosus (SLE). There is a great interest in using microRNAs (miRNAs) as diagnostic and prognostic biomarkers in autoimmune diseases.Materials and methodsThis study evaluated miR‐16, miR‐21, miR‐141, miR‐146a, and miR‐155 expression levels in peripheral blood mononuclear cells (PBMCs) of 55 female SLE patients with absent, inactive, or active nephritis, and 30 healthy controls (HCs) using quantitative polymerase chain reaction.ResultsMiR‐21 and miR‐155 levels were significantly greater in the active nephritis group than in the absent, inactive or HC groups. Moreover, receiver operating characteristic and logistic regression analyses revealed miR‐21 and miR‐155 were significant risk factors for LN.ConclusionOverexpression of miR‐21 and miR‐155 in PBMCs may participate in LN pathophysiology and these miRNAs could be used as biomarkers for the condition.
Antineutrophilic cytoplasmic antibody‐associated vasculitis with and without renal involvement: C3 contributes to prognosis, but renal involvement does not
Authors: Fukui Shoichi , Iwamoto Naoki , Takatani Ayuko , Igawa Takashi , Shimizu Toshimasa , Umeda Masataka , Nishino Ayako , Koga Tomohiro , Kawashiri Shin‐ya , Tamai Mami , Ichinose Kunihiro , Nakamura Hideki , Origuchi Tomoki , Sato Shuntaro , Kawakami Atsushi 
Published: November 2018

AbstractObjectivesWe investigated the impact of renal involvement at diagnosis on the prognosis of patients with antineutrophilic cytoplasmic antibody (ANCA)‐associated vasculitis (AAV).MethodsThe relationship between renal involvement at diagnosis, clinical variables at diagnosis, and prognosis (including relapse episodes, initiation of dialysis, and death) was examined in 101 Japanese patients with AAV.ResultsSixty‐eight patients had renal involvement at diagnosis. The renal‐involvement patients had significantly higher ages at diagnosis, significantly lower hemoglobin levels, and significantly lower platelet levels. They had significantly lower C3 levels, but showed no significant difference in C4 levels. Overall survival rate was significantly worse in patients with than in patients without renal involvement (P = 0.003, log‐rank test). Multivariable analysis using a logistic regression model demonstrated that C3 contributed to dialysis initiation: odds ratio (per 10 mg/dL of C3): 0.68; range: 0.49‐0.90; P = 0.007. A Cox proportional hazard model revealed that the C3 level and age at diagnosis contributed significantly to overall survival: hazard ratio (per 10 mg/dL of C3) 0.81, range 0.69‐0.95, P = 0.011; 1.08, 1.02‐1.15, P = 0.013, respectively. Renal involvement did not contribute significantly to overall survival. Patients with C3 levels ≥100 mg/dL had a better survival rate than patients with C3 levels <100 mg/dL.ConclusionsAlthough patients with renal involvement had higher ages, lower C3 levels at diagnosis, and poorer prognoses, multivariable analysis demonstrated that the C3 level and age at diagnosis, but not renal involvement, contributed significantly to overall survival. Our results demonstrate the relationship between C3 hidden behind renal involvement and AAV prognosis.
Anti‐TIF1γ antibody and the expression of TIF1γ in idiopathic inflammatory myopathies
Authors: Kim Young , Song Kyu Sang , Sohn Eun Hee , Kang Seong Wook , Yoo In Seol , Shim Seung‐Cheol , Yoo Su‐Jin , Kim Jinhyun 
Published: November 2018

AbstractObjectiveAnti‐transcriptional intermediary factor 1 (TIF1) antibody is associated with idiopathic inflammatory myopathies (IIMs). The aim of this study was to investigate the expression of TIF1s in IIMs.MethodTIF1α, β or γ expression in the skin and muscle of patients and controls was studied by immunohistochemistry. Serum myositis‐specific autoantibodies were detected by immunoblot.ResultsTIF1α was expressed in the skin of most dermatomyositis (DM) patients but not in the controls (80% vs 0%, P < 0.001). TIF1β was expressed in all tissues of patients and controls. TIF1γ was expressed in the muscle of DM patients compared to controls (42.1% vs 0%, P = 0.039) and associated with tubuloreticular bodies (P = 0.003). Anti‐TIF1γ was related with TIF1γ expression in the muscle (P = 0.042).ConclusionTIF1α expression in the skin and TIF1γ in the muscle of DM was increased compared to controls. TIF1γ expression in the muscle of IIMs was related to anti‐TIF1γ antibody.
Childhood‐onset Takayasu arteritis: A 15‐year experience from a tertiary referral center
Authors: Sahin Sezgin , Hopurcuoglu Duhan , Bektas Sule , Belhan Ezgi , Adrovic Amra , Barut Kenan , Canpolat Nur , Caliskan Salim , Sever Lale , Kasapcopur Ozgur 
Published: November 2018

AbstractAimTo describe clinical manifestations, angiographic findings, treatment, activity and damage of our Takayasu arteritis patients.MethodThe patients who met European League Against Rheumatism/Paediatric Rheumatology International Trials Organisation/Paediatric Rheumatology European Society classification criteria for childhood‐onset Takayasu arteritis were reviewed in a retrospective longitudinal manner from 2002 to 2017. Extent of the disease was assessed by Disease Extent Index for Takayasu Arteritis (DEI.Tak), activity by Pediatric Vasculitis Activity Score and Indian Takayasu's Arteritis Activity Score (ITAS 2010) and damage by Pediatric Vasculitis Damage Index and Takayasu Arteritis Damage Score (TADS).ResultsSixteen subjects (75% female) with a median disease duration of 3.1 years were enrolled in this study. While the median age at disease onset was 12.1 years, there was only a 2.5 months diagnostic delay. Treatment regime included corticosteroids (100%), which were combined with azathioprine or methotrexate in 93.8% and 37.5% of the subjects, respectively. Severe and refractory cases were treated with cyclophosphamide (62.5%) and subsequently with tocilizumab (37.5%). Seven patients (43.8%) required either percutaneous endovascular intervention or bypass for severe disease refractory to medications. The correlation of the activity and damage scores with each other was fairly good. Damage was found to be associated only with high disease activity and extensive disease at disease onset, but not with other parameters.ConclusionDespite high usage rates of aggressive immunosuppressive therapy and biologic agents, almost half of the patients underwent interventional procedures. When medications failed, endovascular and surgical interventions were of great importance to avoid end‐organ ischemia. The performance of the new activity (DEI.Tak and ITAS2010) and damage indices (TADS) seems satisfactory.
IL‐17Ahaplotype confers susceptibility to systemic lupus erythematosus but not to rheumatoid arthritis in Mexican patients
Authors: Montúfar‐Robles Isela , Barbosa‐Cobos Rosa E. , Alemán‐Ávila Isidro , Ramírez‐Bello Julián 
Published: November 2018

AbstractAimRecent studies highlight the importance of the interleukin (IL)‐17A cytokine in systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA). There are also reports of associations between some single nucleotide polymorphisms (SNPs) inIL‐17Aand RA but not SLE. Notably, these findings have not been replicated in all studied populations. The aim of this study was to investigate whether theIL‐17A‐737 T/C (rs8193036), ‐444A/G (rs3819024), ‐197G/A (rs2275913), and ‐121G/A (rs8193037) SNPs conferred susceptibility to SLE (or lupus nephritis) or to RA in a Mexican population.MethodsThe study included 1367 Mexican subjects, 501 with RA, 367 with SLE, and 499 healthy controls.IL‐17Awas genotyped using a TaqMan 5ʹ allelic discrimination assay.ResultsOur results showed that theIL‐17A‐737 T/C, ‐444A/G, ‐197G/A, and ‐121G/A SNPs had similar genotype and allele frequencies in patients with SLE (or lupus nephritis) or RA and in controls. However, anIL‐17Ahaplotype (TAGA) showed an association with SLE susceptibility (odds ratio 2.43,P = 0.004) but not with RA susceptibility.ConclusionsThese results confirm that theIL‐17A‐737T/C, ‐444A/G, ‐197G/A, and ‐121G/A SNPs are not risk factors for RA, but theIL‐17ATAGA haplotype is a risk factor for SLE. This is the first report to document an association betweenIL‐17Aand SLE susceptibility in adults.
Mortality in autoimmune rheumatic diseases with anti‐Ro/SSA antibody in Korea: Single center‐based retrospective study
Authors: Kim Seong‐Kyu , Choe Jung‐Yoon , Kwak Sang Gyu 
Published: November 2018

AbstractAimThe clinical importance of the anti‐Ro antibody has not been completely understood. This study investigated identification of the association between mortality and clinical features in patients with autoimmune rheumatic diseases and detectable anti‐Ro antibody titers.MethodsWe retrospectively analyzed a total of 336 patients with autoimmune rheumatic diseases and positive anti‐Ro antibody titers from January 2012 to January 2015. Clinical manifestations and other autoantibodies detected during the follow‐up period were identified. Cumulative survival rates were assessed by Kaplan‐Meier analysis. Differences between survival curves for each risk factor were analyzed by log‐rank test. The relative risk of mortality was assessed using standardized mortality ratios (SMRs).ResultsThere was no difference in the mortality rates of patients with autoimmune rheumatic diseases with or without detectable anti‐Ro antibody (SMR: 1.373, 95% CI: 0.539‐2.791). Six patients (4 with systemic lupus erythematosus [SLE] and two with Sjögren's syndrome [SS]) died during the follow‐up period. In the whole study population, the mortality rate of patients with lymphopenia was higher than those without lymphopenia (P = 0.023). In a sub‐group of patients with both SLE and SS, Kaplan‐Meier analysis showed that lymphopenia and interstitial lung disease were associated with increased mortality (P = 0.024 and P = 0.023, respectively).ConclusionThis study demonstrated that presence of the anti‐Ro antibody was not associated with increased mortality in patients with autoimmune rheumatic disease. Conversely, we found that lymphopenia was independently associated with mortality in patients with autoimmune rheumatic disease.
Effect of interaction between leucine and acetate on the milk protein synthesis in bovine mammary epithelial cells
Authors: Zhao Yanli , Yan Sumei , Chen Lu , Shi Binlin , Guo Xiaoyu 
Published: November 2018

AbstractThe interaction between Leucine (Leu) and acetate affecting milk protein synthesis in the bovine mammary epithelial cells (BMECs), and underlying the molecular mechanisms are not well understood. The objectives of this study were to investigate the effect of Leu, acetate, and their interaction on the expression of genes involved in milk protein synthesis, and JACK2/STAT5, mTOR and AMP‐activated protein kinase (AMPK) signaling pathway. The study was a 2 × 6 factorial arrangement with treatments: Leu concentration (0.45 and 1.8 mM) and acetate concentration (0, 4, 6, 8, 10, and 12 mM). The results showed that 1.8 mM Leu or 8–10 mM acetate had positive effect on ATP content, the expression of casein genes, JACK2/STAT5 and phosphorylation of mTOR pathway, but reduced AMPK phosphorylation. Leu at 1.8mM had a positive effect on the up‐regulation of acetate on ATP content, the expression of CSN1S1, CSN2, CSN3, and JACK2, the expression and phosphorylation of eukaryotic initiation factor 4E, p70 ribosomal protein S6 kinase‐1, and mTOR, but reducing AMPK phosphorylation. The results suggest that acetate, Leu, and their interaction have effect on milk protein synthesis through the JACK2/STAT5, mTOR, and AMPK pathway. Acetate addition up‐regulated the effect of Leu on milk protein synthesis, and Leu facilitated the up‐regulation of acetate on milk protein synthesis through these pathways.
Spiritual education programme for primary caregiver parents to build resilience in children with acute anxiety symptoms: A multicity study
Authors: Pandya Samta P. 
Published: November 2018

AbstractThis article reports a multicity 1‐year long study on the effect of a customized spiritual education programme (SEP) on parenting and in turn its mediated effect on resilience building for children with acute anxiety symptoms. The treatment group comprised 3,689 primary caregiver parents who participated in the SEP and their children clinically diagnosed with acute anxiety symptoms, from 180 schools across 15 cities. Equal number of primary caregiver parents and children were assigned to the control group. Results showed that post‐test scores of treatment group primary caregiver parents were higher on the parenting style questionnaires, indicating an improved and authoritative parenting style. This positive effect of the SEP on parenting in turn had a mediating effect on resilience of their children, who scored higher on the outcome measures in the post‐treatment phase. Parenting and resilience outcome measures varied due to socio‐economic and SEP‐related variables. Children's perception of post‐treatment parenting influenced their resilience. Findings suggest that SEP could aid positive parenting and hence positive behavioural outcomes in children.
Bidirectional regulation of osteogenic differentiation by the FOXO subfamily of Forkhead transcription factors in mammalian MSCs
Authors: Chen Duanjing , Gong Yuanyuan , Xu Ling , Zhou Mengjiao , Li Jie , Song Jinlin 
Published: November 2018

AbstractThrough loss‐ and gain‐of‐function experiments in knockout and transgenic mice, Forkhead box O (FOXO) family transcription factors have been demonstrated to play essential roles in many biological processes, including cellular proliferation, apoptosis and differentiation. Osteogenic differentiation from mesenchymal stem cells (MSCs) into osteoblasts is a well‐organized process that is carefully guided and characterized by various factors, such as runt‐related transcription factor 2 (Runx2), β‐catenin, osteocalcin (OCN), alkaline phosphatase (ALP) and activating transcription factor 4 (ATF4). Accumulating evidence suggests multiple interactions among FOXO members and the differentiation regulatory factors listed above, resulting in an enhancement or inhibition of osteogenesis in different stages of osteogenic differentiation. To systematically and integrally understand the role of FOXOs in osteogenic differentiation and explain the contrary phenomena observed in vitro and in vivo, we herein summarized FOXO‐interacting differentiation regulatory genes/factors and following alterations in differentiation. The underlying mechanism was further discussed on the basis of binding types, sites, phases and the consequent downstream transcriptional alterations of interactions among FOXOs and differentiation regulatory factors. Interestingly, a bidirectional effect of FOXOs on balancing osteogenic differentiation was discovered in MSCs. Moreover, FOXO factors are reported to be activated or suppressed by several context‐dependent signalling inputs during differentiation, and the underlying molecular basis may offer new drug development targets for treatments of bone formation defect diseases.
Effectiveness of nursing interventions for breathlessness in people with chronic obstructive pulmonary disease: A systematic review and meta‐analysis
Authors: Steindal Simen A. , Torheim Henny , Oksholm Trine , Christensen Vivi L. , Lee Kathryn , Lerdal Anners , Markussen Heidi Øksnes , Gran Gerd , Leine Marit , Borge Christine Råheim 
Published: November 2018

AbstractAimTo critically review and synthesize the findings of studies that evaluated the effectiveness of nursing interventions for improving breathlessness in adults with chronic obstructive pulmonary disease.BackgroundSystematic reviews of nursing interventions for breathlessness in people with chronic obstructive pulmonary disease have not been specifically addressed.DesignSystematic review with meta‐analysis.Data sourcesA systematic search of Medline, CINAHL, PsycINFO and Embase was performed for studies published between January 2000 and June 2017.Review methodsRisk of bias, data extraction and meta‐analysis were conducted using Cochrane methodology. The quality of evidence was assessed using the GRADE approach.ResultsTwenty papers were included. A meta‐analysis of interventions performed at home, including two trials, showed a significant effect in favour of experimental groups for the symptom score of the St. George Respiratory Questionnaire compared with controls. A meta‐analysis of interventions performed in clinics with home follow‐up showed a significant effect in favour of experimental groups for the mastery and fatigue scores of the Chronic Respiratory Questionnaire compared with controls. In this category of intervention, an additional meta‐analysis showed a significant effect in favour of experimental groups for the symptom, activity and total scores of the St. George Respiratory Questionnaire compared with controls. The quality of evidence was assessed to be very low to moderate.ConclusionThe results are equivocal as to whether nursing interventions performed at home and nursing interventions performed in hospital with follow‐up improve breathlessness in people with chronic obstructive pulmonary disease.
Self‐care interventions for adults with heart failure: A systematic review and meta‐analysis protocol
Authors: Ruppar Todd M. , Cooper Pamela S. , Johnson E. Diane , Riegel Barbara 
Published: November 2018

AbstractAimTo synthesize and compare outcomes from controlled trials of interventions to improve heart failure self‐care among adults.BackgroundHeart failure self‐care interventions are recommended for preventing and detecting exacerbations, improving symptom management and preventing hospitalizations. Little is known about the overall effectiveness of heart failure self‐care programmes and which types of interventions show the greatest improvement in outcomes.DesignSystematic review and meta‐analysis, including moderator analyses.MethodsMultiple databases (including MEDLINE/PubMed, CINAHL, PsycINFO, Scopus and Cochrane Central Register of Controlled Trials) will be searched from inception through 2018 along with grey literature searches to identify trials testing interventions to improve self‐care outcomes of adults with heart failure. Data will be extracted from eligible studies on sample, methodological and intervention characteristics and data to calculate effect sizes. Data will be analysed using random‐effects models. Moderator variables will be analysed with meta‐regression and sub‐group analyses. Risk for bias will be assessed using the Cochrane Risk for Bias tool and by examining potential sources of bias as moderator variables. Funding for this project began in July 2017.DiscussionWe will analyse self‐care behaviour outcomes and clinical outcomes including hospitalizations, mortality, disease severity and quality of life. This will be the most extensive meta‐analysis of heart failure self‐care interventions to date.Impact

Comparative effectiveness of existing self‐care interventions is not yet known.

This research will identify the most promising self‐care intervention components for designing better interventions and guide targeting of interventions to specific sub‐populations.

PROSPERO Registration Number: CRD42017075831
Infection prevention climate and its influence on nursing students’ compliance with standard precautions
Authors: Cruz Jonas Preposi 
Published: November 2018

AbstractAimThis study examined the influence of the training hospital's infection prevention climate on the nursing students’ compliance with standard precautions during clinical training.BackgroundThe concept of infection prevention climate has emerged in healthcare facilities due to the acknowledged influence of organizational culture on the compliance of healthcare workers on infection prevention and control practices. However, the influence of training hospital's infection prevention climate on nursing students’ compliance with standard precautions has never been investigated.DesignA descriptive, cross‐sectional design.MethodsA convenience sample of 254 nursing students in Saudi Arabia was surveyed using the Leading Culture of Quality in Infection Prevention and the Compliance with Standard Precautions Scale from October 2017–January 2018.ResultsThe students perceived their training hospital's infection prevention climate as moderately positive. The students’ age, year of study, and attendance to infection prevention and control training in the last 6 months exerted multivariate effects on the four dimensions and on the overall infection prevention climate. The nursing students’ compliance with standard precautions was moderate. Age, gender, year of study, attendance to infection prevention and control training, and perceived training hospital's infection prevention climate were identified as factors that significantly influenced the students’ compliance with SPs.ConclusionsThis study underscored the importance of maintaining high quality of infection prevention climate of training hospitals as it influences the development of competencies in infection prevention and control of nursing students.
An mHealth intervention programme to promote healthy behaviours and prevent adolescent obesity (TeenPower): A study protocol
Authors: Sousa Pedro , Duarte Emília , Ferreira Regina , Esperança Ana , Frontini Roberta , Santos‐Rocha Rita , Luís Luís , Dias Sara S. , Marques Nuno 
Published: November 2018

AbstractAimThis paper describes the design and rationale of multicenter practice‐based research that aims to develop and evaluate an innovative mobile health (mHealth) intervention programme directed to promote healthy behaviours and prevent adolescent obesity.DesignThis study is designed as a non‐randomized controlled trial with a three‐arm structure.MethodsTwelve to 16 years old participants will be recruited from schools, with access to the Internet and smartphone/tablet devices. The intervention group will be invited to engage in the TeenPower mHealth programme and divided into two subgroups: Group A (additionally engaged in a structured school‐based intervention programme) and Group B (only engaged in the mHealth programme). The mHealth app includes educational resources, self‐monitoring, social support, interactive training modules and motivational tools. The control group will only follow the structured school‐based intervention programme. The intervention length will be 3 months, including the direct support of an interdisciplinary team (nursing, nutrition, sports, psychology, among others). This research was approved and funded in August 2017.DiscussionThe positive evaluation of the intervention programme will stimulate the inclusion of technologies in the promotion of salutogenic behaviours and obesity prevention.ImpactAdolescent obesity reached epidemic proportions. It is urgent to find effective prevention strategies to induce change at the individual, family and community level. If effective, this protocol can be used by health and exercise professionals in improving community interventions tailored to teenagers.