bluuebunny/crossref_metadata_2025_split huggingface dataset:
ANXA7 regulates trophoblast proliferation and apoptosis in preeclampsia
Authors: Mo Hui‐Qin , Tian Fu‐Ju , Li Xiao , Zhang Jing , Ma Xiao‐Ling , Zeng Wei‐Hong , Lin Yi , Zhang Yan 
Published: August 2019

AbstractProblemPreeclampsia (PE) is a unique gestational disorder leading to maternal and neonatal morbidity and mortality. AnnexinA7 (ANXA7) is a calcium‐dependent phospholipid‐binding protein that promotes membrane fusion during exocytosis. However, the function of ANXA7 in placental trophoblast is poorly understood. The present study aimed to investigate a possible association between ANXA7 and human trophoblast apoptosis.MethodsWe collected human placental tissues from patients with PE and normal pregnant women to elucidate the expression level of ANXA7. The ANXA7‐knockdown and ANXA7‐overexpressing HTR8/SVneo cells were utilized for studying the function of ANXA7 in trophoblast. The proliferation and apoptosis levels of trophoblast were examined with Western blot assay, flow cytometry, Cell Counting Kit‐8 assay, and immunohistochemistry.ResultsANXA7 expression was significantly lower in placentas from patients with PE patients compared with that in from normal pregnant controls. Knockdown of ANXA7 induced cell apoptosis and inhibited cell proliferation in HTR‐8 via by downregulating BCL2 protein levels. Overexpression of ANXA7 reduced apoptosis and promoted HTR8 proliferation. Further analyses showed that ANXA7 knockdown inhibited the activation of the JAK1/STAT3 pathway in HTR‐8 cells.ConclusionOur findings revealed a new regulatory pathway of ANXA7/JAK1/STAT3 in trophoblast apoptosis in preeclampsia, suggesting that ANXA7 is a potential therapeutic target for preeclampsia.
In vitro interaction of glutathione S‐transferase‐pi enzyme with glutathione‐coated silver sulfide quantum dots: A novel method for biodetection of glutathione S‐transferase enzyme
Authors: Aydemir Duygu , Hashemkhani Mahshid , Acar Havva Yagci , Ulusu Nuriye Nuray 
Published: August 2019

AbstractQuantum dots (QD) are being evaluated as inorganic nanoparticles for both in vitro and in vivo optical imaging. They are also used as sensors or vehicles for targeted drug delivery combined with optical imaging. In this study, we demonstrated that glutathione‐coated Ag2S QDs (GSH‐Ag2S QDs) act as a substrate analogue of glutathione S‐transferase (GST) enzymes for the first time in the literature. The GSTs belong to a major group of detoxification enzymes involved in the detoxification metabolism responsible for the protection of cells against reactive oxygen species (ROS) or electrophiles. GST isozymes are impaired in the various diseases such as neurological diseases and cancer. We evaluated the interaction of GST‐pi enzyme with GSH‐Ag2S QDs, which have never been studied in the literature before, using both fluorometric and spectrophotometric methods. Our data showed that GSH‐Ag2S QDs gave reaction with GST enzyme as a substrate analogue. In conclusion, our data may help to guide researchers for further development of sensing systems for GST activity which is impaired in various diseases including cancer.
Information Integration in Modulation of Pragmatic Inferences During Online Language Comprehension
Authors: Ryskin Rachel , Kurumada Chigusa , Brown‐Schmidt Sarah 
Published: August 2019

AbstractUpon hearing a scalar adjective in a definite referring expression such as “the big…,” listeners typically make anticipatory eye movements to an item in a contrast set, such as a big glass in the context of a smaller glass. Recent studies have suggested that this rapid, contrastive interpretation of scalar adjectives is malleable and calibrated to the speaker's pragmatic competence. In a series of eye‐tracking experiments, we explore the nature of the evidence necessary for the modulation of pragmatic inferences in language comprehension, focusing on the complementary roles of top–down information ‐ (knowledge about the particular speaker's pragmatic competence) and bottom‐up cues (distributional information about the use of scalar adjectives in the environment). We find that bottom‐up evidence alone (e.g., the speaker says “the big dog” in a context with one dog), in large quantities, can be sufficient to trigger modulation of the listener's contrastive inferences, with or without top‐down cues to support this adaptation. Further, these findings suggest that listeners track and flexibly combine multiple sources of information in service of efficient pragmatic communication.
Learning How to Generalize
Authors: Austerweil Joseph L. , Sanborn Sophia , Griffiths Thomas L. 
Published: August 2019

AbstractGeneralization is a fundamental problem solved by every cognitive system in essentially every domain. Although it is known that how people generalize varies in complex ways depending on the context or domain, it is an open question how people learn the appropriate way to generalize for a new context. To understand this capability, we cast the problem of learning how to generalize as a problem of learning the appropriate hypothesis space for generalization. We propose a normative mathematical framework for learning how to generalize by learning inductive biases for which properties are relevant for generalization in a domain from the statistical structure of features and concepts observed in that domain. More formally, the framework predicts that an ideal learner should learn to generalize by either taking the weighted average of the results of generalizing according to each hypothesis space, with weights given by how well each hypothesis space fits the previously observed concepts, or by using the most likely hypothesis space. We compare the predictions of this framework to human generalization behavior with three experiments in one perceptual (rectangles) and two conceptual (animals and numbers) domains. Across all three studies we find support for the framework's predictions, including individual‐level support for averaging in the third study.
Epiregulin enhances odontoblastic differentiation of dental pulp stem cells via activating MAPK signalling pathway
Authors: Cui Dixin , Xiao Jiani , Zhou Yachuan , Zhou Xin , Liu Ying , Peng Yiran , Yu Yi , Li Hongyu , Zhou Xuedong , Yuan Quan , Wan Mian , Zheng Liwei 
Published: August 2019

AbstractObjectivesThe odontoblastic differentiation of dental pulp stem cells (DPSCs) contributes to tertiary dentin formation. Our previous study indicated that epiregulin (EREG) enhanced odontogenesis potential of dental pulp. Here, we explored the effects of EREG during DPSC odontoblastic differentiation.MethodsThe changes in EREG were detected during tertiary dentin formation. DPSCs were treated with recombinant human EREG (rhEREG), EREG receptor inhibitor gefitinib and short hairpin RNAs. The odontoblastic differentiation was assessed with ALP staining, ALP activity assay, alizarin red S staining and real‐time RT‐PCR of DSPP, OCN, RUNX2 and OSX. Western blot was conducted to examine the levels of p38 mitogen‐activated protein kinase (p38 MAPK), c‐Jun N‐terminal kinase (JNK) and extracellular signal‐regulated kinase 1/2 (Erk1/2). The expression of EREG and odontoblastic differentiation‐related markers was investigated in human dental pulp from teeth with deep caries and healthy teeth.ResultsEpiregulin was upregulated during tertiary dentin formation. rhEREG enhanced the odontoblastic differentiation of DPSCs following upregulated p38 MAPK and Erk1/2 phosphorylation, but not JNK, whereas depletion of EREG suppressed DPSC differentiation. Gefitinib decreased odontoblastic differentiation with decreased phosphorylation of p38 MAPK and Erk1/2. And suppression of p38 MAPK and Erk1/2 pathways attenuated DPSC differentiation. In human dental pulp tissue, EREG upregulation in deep caries correlates with odontoblastic differentiation enhancement.ConclusionEpiregulin is released during tertiary dentin formation. And EREG enhanced DPSC odontoblastic differentiation via MAPK pathways.
907. FRITILLARIA FORBESII
Authors: Rix Martyn 
Published: August 2019

SummaryFritillaria forbesii Baker from south‐western Turkey is illustrated and the history of its discovery and present distribution around Fethiye are given. It is compared with the recently‐described Fritillaria mughlae Tekşen & Aytaç, a serpentine endemic from nearby Marmaris.
A neurophysiological investigation of anticipation to pain in Parkinson's disease
Authors: Martin Sarah L. , Jones Anthony K. P. , Brown Christopher A. , Kobylecki Christopher , Silverdale Monty A. 
Published: August 2019

AbstractChronic pain is common in people with Parkinson's disease and is often considered to be caused by the motor impairments associated with the disease. Altered top‐down processing of pain characterises several chronic pain conditions and occurs when the cortex modifies nociceptive processing in the brain and spinal cord. This contrasts with bottom‐up modulation of pain whereby nociceptive processing is modified on its way up to the brain. Although several studies have demonstrated altered bottom‐up pain processing in Parkinson's, the contribution of enhanced anticipation to pain and atypical top‐down processing of pain has not been fully explored. During the anticipation to noxious stimuli, EEG source localisation reported an increased activation in the midcingulate cortex and supplementary motor area in the Parkinson's disease group compared to the healthy control group during mid [−1,500 –1,000]‐and late anticipation [−500 0], indicating enhanced cortical activity before noxious stimulation. The Parkinson's disease group was also more sensitive to the laser and required a lower voltage level to induce pain. This study provides evidence supporting the hypothesis that enhanced top‐down processing of pain may contribute to the development of chronic pain in Parkinson's. Additional research to establish whether the altered anticipatory response is unique to noxious stimuli is required as no control stimulus was used within the current study. With further research to confirm these findings, our results inform a scientific rationale for novel treatment strategies of pain in Parkinson's disease, including mindfulness, cognitive therapies and other approaches targeted at improving top‐down processing of pain.
The epistemic limits of shared reasons
Authors: Motchoulski Alexander 
Published: August 2019

AbstractAccounts of public reason disagree as to the conditions a reason must meet in order to qualify as public. On one prominent account, a reason is public if, and only if, it is shareable between citizens. The shareability account, I argue, relies on an implausibly demanding assumption regarding the epistemic capabilities of citizens. When more plausible, limited, epistemic capabilities are taken into consideration, the shareability account becomes self‐defeating. Under more limited epistemic conditions, few, if any, reasons will be shareable between all reasonable citizens, making the shareability account so demanding that it precludes public reasoning altogether.
Development and accuracy of an artificial intelligence algorithm for acne grading from smartphone photographs
Authors: Seité Sophie , Khammari Amir , Benzaquen Michael , Moyal Dominique , Dréno Brigitte 
Published: August 2019

AbstractWe developed an artificial intelligence algorithm (AIA) for smartphones to determine the severity of facial acne using the GEA scale and to identify different types of acne lesion (comedonal, inflammatory) and postinflammatory hyperpigmentation (PIHP) or residual hyperpigmentation. Overall, 5972 images (face, right and left profiles) obtained with smartphones (IOS and/or Android) from 1072 acne patients were collected. Three trained dermatologists assessed the acne severity for each patient. One acne severity grade per patient (grade given by the majority of the three dermatologists from the two sets of three images) was used to train the algorithm. Acne lesion identification was performed from a subgroup of 348 images using a tagging tool; tagged images served to train the algorithm. The algorithm evolved and was adjusted for sensibility, specificity and correlation using new images. The correlation between the GEA grade and the quantification and qualification of acne lesions both by the AIA and the experts for each image were evaluated for all AIA versions. At final version 6, the GEA grading provided by AIA reached 68% and was similar to that provided by the dermatologists. Between version 4 and version 6, AIA improved precision results multiplied by 1.5 for inflammatory lesions, 2.5 for non‐inflammatory lesions and by 2 for PIHP; recall was improved by 2.6, 1.6 and 2.7. The weighted average of precision and recall or F1 score was 84% for inflammatory lesions, 61% for non‐inflammatory lesions and 72% for PIHP.
Fracture damage prediction in fissured red sandstone under uniaxial compression: acoustic emission b‐value analysis
Authors: Niu Yong , Zhou Xiao‐Ping , Zhou Lun‐Shi 
Published: August 2019

AbstractIn this paper, uniaxial compression tests are conducted on fissured red sandstone specimens to predict fracture damage (large‐scale events). The acoustic mission (AE) coupled with digital image correlation (DIC) technologies are used to monitor and record the real‐time cracking process of tested specimens. The AE characteristics are analysed during the cracking process. Moreover, three types of b‐value methods based on the AE parameters are adopted to predict the occurrence of large‐scale events (macro‐cracking). The results show that every macro‐cracking leads to a rapid decrease in three types of b value. When the fissured specimens reach to ultimate failure, all three types of b value reach to the minimum. The b value based on the AE parameters can be used as a predictor of large‐scale events during the cracking process of fissured rocks.
Seasonal changes in European whitefish muscle and invertebrate prey fatty acid composition in a subarctic lake
Authors: Keva Ossi , Tang Patrik , Käkelä Reijo , Hayden Brian , Taipale Sami J. , Harrod Chris , Kahilainen Kimmo K. 
Published: August 2019

Abstract

Ambient light and temperature show extreme seasonal variation in subarctic lakes due to the midnight sun period in summer and cold polar night period in winter. These changes have clear impacts on fish feeding and reproduction cycles, potentially affecting the fatty acid (FA) composition of muscle. Despite extensive research into fish FA over recent decades, we know little about intra‐annual changes of fish FA profile and content.

We studied intra‐annual changes in the FA profile (mol%) and content (mg g‐1 dry weight) of sexually mature European whitefish (Coregonus lavaretus) muscle in a large and deep subarctic lake located in northern Fennoscandia. We collected fish, zooplankton, and benthic macroinvertebrate samples during 3 ice‐covered months, including December (during whitefish spawning), and 3 open‐water months. Fish size, age, sex, stomach content and fullness, and gonadosomatic index were also assessed as co‐variates.

Whitefish changed diet from benthic macroinvertebrates in winter to zooplankton in summer. Generally, whitefish somatic growth was slow and most energy was used for gonad growth. Zooplankton had higher total content and different profile of FA compared to benthic macroinvertebrates. Increased zooplanktivory in summer was detected with higher α‐linolenic acid (ALA, 18:3n‐3) and stearidonic acid (SDA, 18:4n‐3) percentage and content as well as increased the ratio of polyunsaturated FAs (PUFAs) of n‐3 and n‐6 family (n‐3/n‐6 ratio) in fish muscle.

Whitefish gonadal growth and development occur during the summer growing season and continue until the initiation of spawning in early winter. We found that the content of physiologically crucial PUFA, eicosapentaenoic acid (EPA, 20:5n‐3), docosahexaenoic acid (DHA, 22:6n‐3), and arachidonic acid (ARA, 20:4n‐6) decreased by c. 60% between late summer and the spawning period in early winter. After spawning, total FA content of whitefish muscle increased rapidly, reaching the maximum recorded level in mid‐summer.

Intra‐annual changes in whitefish muscle FA profiles and contents were modified both by available diet and reproductive phase; however, reproductive physiology was clearly a stronger driver of the changes in muscle FA composition. Results suggest marked changes in intra‐annual FA composition of fish muscle, an important factor that should be considered in future studies and especially in long term monitoring programs. Future studies are needed to determine whether these inter‐annual FA patterns revealed in this study can be extended to different regions and to e.g. adipose or spring spawning species.
Warming enhances the stimulatory effect of algal exudates on dissolved organic carbon decomposition
Authors: Wyatt Kevin H. , Rober Allison R. 
Published: August 2019

Abstract

The current paradigm in peatland ecology is that the organic matter inputs from plant photosynthesis (e.g. moss litter) exceed that of decomposition, tipping the metabolic balance in favour of carbon (C) storage. Here, we investigated an alternative hypothesis, whereby exudates released by microalgae can actually accelerate C losses from the surface waters of northern peatlands by stimulating dissolved organic C (DOC) decomposition in a warmer environment expected with climate change. To test this hypothesis, we evaluated the biodegradability of fen DOC in a factorial design with and without algal DOC in both ambient (15°C) and elevated (20°C) water temperatures during a laboratory bioassay.

When DOC sources were evaluated separately, decomposition rates were higher in treatments with algal DOC only than with fen DOC only, indicating that the quality of the organic matter influenced degradability. A mixture of substrates (½ algal DOC + ½ fen DOC) exceeded the expected level of biodegradation (i.e. the average of the individual substrate responses) by as much as 10%, and the magnitude of this effect increased to more than 15% with warming.

Specific ultraviolet absorbance at 254 nm (SUVA254), a proxy for aromatic content, was also significantly higher (i.e. more humic) in the mixture treatment than expected from SUVA254 values in single substrate treatments.

Accelerated decomposition in the presence of algal DOC was coupled with an increase in bacterial biomass, demonstrating that enhanced metabolism was associated with a more abundant microbial community.

These results present an alternative energy pathway for heterotrophic consumers to breakdown organic matter in northern peatlands. Since decomposition in northern peatlands is often limited by the availability of labile organic matter, this mechanism could become increasingly important as a pathway for decomposition in the surface waters of northern peatlands where algae are expected to be more abundant in conditions associated with ongoing climate change.
Cortical Hyper‐Excitability in Migraine in Response to Chromatic Patterns
Authors: Haigh Sarah M. , Chamanzar Alireza , Grover Pulkit , Behrmann Marlene 
Published: August 2019

ObjectiveIndividuals with migraine exhibit heightened sensitivity to visual input that continues beyond their migraine episodes. However, the contribution of color to visual sensitivity, and how it relates to neural activity, has largely been unexplored in these individuals.BackgroundPreviously, it has been shown that, in non‐migraine individuals, patterns with greater chromaticity separation evoked greater cortical activity, regardless of hue, even when colors were isoluminant. Therefore, to investigate whether individuals with migraine experienced increased visual sensitivity, we compared the behavioral and neural responses to chromatic patterns of increasing separation in migraine and non‐migraine individuals.MethodsSeventeen individuals with migraine (12 with aura) and 18 headache‐free controls viewed pairs of colored horizontal grating patterns that varied in chromaticity separation. Color pairs were either blue‐green, red‐green, or red‐blue. Participants rated the discomfort of the gratings and electroencephalogram was recorded simultaneously.ResultsBoth groups showed increased discomfort ratings and larger N1/N2 event‐related potentials (ERPs) with greater chromaticity separation, which is consistent with increased cortical excitability. However, individuals with migraine rated gratings as being disproportionately uncomfortable and exhibited greater effects of chromaticity separation in ERP amplitude across occipital and parietal electrodes. Ratings of discomfort and ERPs were smaller in response to the blue‐green color pairs than the red‐green and red‐blue gratings, but this was to an equivalent degree across the 2 groups.ConclusionsTogether, these findings indicate that greater chromaticity separation increases neural excitation, and that this effect is heightened in migraine, consistent with the theory that hyper‐excitability of the visual system is a key signature of migraine.
Long‐Term Care Crisis in The Netherlands and Migration of Live‐in Care Workers: Transnational Trajectories, Coping Strategies and Motivation Mixes
Authors: Bruquetas‐Callejo María 
Published: August 2019

AbstractThe crisis of the welfare state has generated a powerful pulling effect for contemporary intra‐European migration flows. This article focuses on the migration of live‐in care workers from Central and East European countries to the Netherlands, following the Dutch care reform. It explores the motivations and strategies of live‐in migrant carers (LIMC) engaging in transnational mobility, aiming to understand how their agency is structured in multiple contexts. I am especially interested in transnational coping strategies and in how migrants pursue specific motivation mixes combining need and self‐realization. The article draws on in‐depth interviews with LIMC workers, triangulated with data from LIMC providers, family carers and other stakeholders. Participants use the LIMC jobs to cope with home and host country constraints, reconcile work and private life, and keep family ties. Continuous mobility is a strategic choice, which makes tough working conditions bearable and enables the achievement of long‐term goals.
The Care/Security Nexus of the Humanitarian Border: Assisted Return in Norway
Authors: Bendixsen Synnøve 
Published: August 2019

AbstractWhile Assisted Return and deportation are frequently viewed as two different return policies, the first represented as humanitarian and the latter as enforcement, this article argues that there is a continuum between these policies and that they form part of humanitarian border enforcement. Drawing on policy document analysis and interviews with NGOs and with irregular migrants, the article provides a two‐level analysis by examining how AR is presented from the Norwegian governmental perspective and how it is experienced from the Afghan migrant perspectives. The article argues that the government bases its AR policy on the need to maintain the credibility and sustainability of the asylum system, as part of fighting crime, while presenting it as a humanitarian solution. For irregular migrants, however, the experienced lack of proper asylum procedures delegitimizes return policies. Overall, the performative aspects of humanitarianism in return policies contribute to depoliticizing return.