bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Single Lab Test to Aid Pierre Robin Sequence Severity Diagnosis
Authors: Fahradyan Artur , Azadgoli Beina , Tsuha Michaela , Urata Mark M. , Francis Stacey H. 
Published: May 2018

Objective: The workup of patients with Pierre Robin sequence (PRS) consists of a physical examination, O2 saturation, and polysomnography to determine the severity of respiratory obstruction and need for surgery. We suggest that capillary blood gas (CBG) may be a better physiologic representation of airway obstruction and should be routinely used in the management of patients with PRS. Design: This is a multicenter study based on a retrospective review of medical records. Setting: The study was performed at tertiary care centers. Interventions: Patients with PRS <1 year old underwent mandibular distraction osteogenesis. Main Outcome Measure: Using successful treatment outcome as a reference standard, receiver operating characteristic (ROC) curve was used to determine the accuracy of the diagnostic test and values for the best sensitivity and specificity to determine the need for surgical intervention. Results: Of 73 patients, 48 had sporadic PRS, 23 had syndromes, 2 had micrognathia, not otherwise specified. Mandibular distraction osteogenesis was performed in 62 patients at a mean age of 39 days. The mean initial Apnea-Hypopnea Index (AHI) in nonsurgical versus surgical groups was 10 versus 31 ( P = .063), pH 7.41 versus 7.34 ( P = .003), pCO2 43 versus 56 ( P < .001), and HCO3 27 versus 30 ( P = .022). The ROC curve showed that pCO2 of 49.5 has the best specificity (100%) and sensitivity (72.6%) profile in terms of need for definitive airway. Conclusion: A simple CBG heel stick may better predict the physiologic effects of obstructive apnea; therefore, it should be added to the algorithm of PRS workup.
Evidence for telehealth group-based treatment: A systematic review
Authors: Gentry Melanie T , Lapid Maria I , Clark Matthew M , Rummans Teresa A 
Published: May 2018

Background Interest in the use of telehealth interventions to increase access to healthcare services is growing. Group-based interventions have the potential to increase patient access to highly needed services. The aim of this study was to systematically review the available literature on group-based video teleconference services. Methods The English-language literature was searched using Ovid MEDLINE, PubMed, PsycINFO and CINAHL for terms related to telehealth, group therapy and support groups. Abstracts were reviewed for relevance based on inclusion criteria. Multiple study types were reviewed, including open-label, qualitative and randomised controlled trial study designs. Data were compiled regarding participants, study intervention and outcomes. Specific areas of interest were the feasibility of and satisfaction with telehealth technology, as well as the effect of video teleconference delivery on group dynamics, including therapeutic alliance. Results Forty published studies met the inclusion criteria and were included in the review. Six were randomised controlled trials. Among the studies, there was a broad range of study designs, participants, group interventions and outcome measures. Video teleconference groups were found to be feasible and resulted in similar treatment outcomes to in-person groups. However, few studies were designed to demonstrate noninferiority of video teleconference groups compared with in-person groups. Studies that examined group process factors showed small decreases in therapeutic alliance in the video teleconference participants. Conclusions Video teleconference groups are feasible and produce outcomes similar to in-person treatment, with high participant satisfaction despite technical challenges. Additional research is needed to identify optimal methods of video teleconference group delivery to maximise clinical benefit and treatment outcomes.
Postural Stability and Physical Activity of Workers Working at Height
Authors: Cyma Magdalena , Marciniak Katarzyna , Tomczak Maciej , Stemplewski Rafał 
Published: May 2018

The purpose of the study was to analyze the level of postural stability and physical activity of at-height workers. The study included 34 healthy men aged 25–43. Two groups were identified based on the type of work they performed: at-height workers (HW) ( n = 17), and office workers (OW) ( n = 17). Physical activity, including physical activity at work, sports activity, and leisure, was assessed with a Baecke questionnaire. For evaluation of postural stability, the one-leg standing test with eyes open and closed was used. The HW group had a higher rate of average physical activity at work than the OW group ( p = .000), whereas the OW group showed greater physical activity during leisure time ( p = .000). No differences were found between the groups in terms of sports activity. Postural stability analysis shows that the HW group ( p < .05) scored statistically significantly higher values in one-leg standing with eyes closed. The groups differed in terms of postural stability in favor of HW. At the same time, despite differences in particular aspects, the overall level of PA was similar. This may indicate that postural stability is rather affected by exposure to distress conditions.
L-citrulline supplementation in the treatment of pulmonary hypertension associated with bronchopulmonary dysplasia in preterm infant: A case report
Authors: Lauterbach Ryszard , Pawlik Dorota , Lauterbach Jan Paweł 
Published: May 2018

Introduction: the aim of this case report is to present that oral L-citrulline supplementation may attenuate chronic pulmonary hypertension and reduce oxygen requirement in infants with severe bronchopulmonary dysplasia. Important clinical findings: a boy, with a birth weight of 700 g, born by cesarean section after 25 weeks of pregnancy complicated with preeclampsia, was admitted to the neonatal intensive care unit. He was ventilatory dependent for the next 3 months with significantly increased oxygen requirements. A severe stage of bronchopulmonary dysplasia, complicated with increased pulmonary vascular resistance, was diagnosed. Treatment with inhaled nitric oxide and oral sildenafil was included in the therapy of chronic pulmonary hypertension. The results of screening echocardiograms and increased plasma brain natriuretic peptide concentrations, suggested right ventricle dysfunction. The main intervention: at the beginning of the sixth month of hospitalization, oral supplementation of L-citrulline in a single dose of 150 mg/kg/day was introduced and continued for 70 days. During the first 3 weeks after L-citrulline was started, the patient was weaned from mechanical ventilation and he was never intubated again until he was discharged. Plasma brain natriuretic peptide concentrations decreased significantly during the first month of L-citrulline administration and became stable until the termination of L-citrulline supplementation. At discharge, the patient required 22%–25% concentration of oxygen supplemented intermittently, exclusively during feeding. Conclusion: these results indicate that L-citrulline supplementation may deserve coverage as an additional, potentially beneficial alternative in the prophylaxis or therapy of chronic pulmonary hypertension in newborns.
Novel treatment using topical malachite green for nasal phaeohyphomycosis caused by a new Cladophialophora species in a cat
Authors: Brooks Ian J , Walton Stuart A , Shmalberg Justin , Harris Autumn 
Published: May 2018

Case summary A 1.5-year-old castrated male domestic shorthair cat presented with a 2 month history of progressive nasal swelling and hyporexia. Minimal improvement prior to referral was achieved with a course of antibiotics and glucocorticoids. Cytology of an ulcerative lesion on the dorsal aspect of the nose was consistent with a diagnosis of phaeohyphomycosis. The cat achieved static disease for 6 weeks following initiation of itraconazole but developed epistaxis at 9 weeks. CT of the head demonstrated nasal and frontal sinus involvement. Nasal biopsy and culture identified infection with a Cladophialophora species not previously reported to cause disease. Initial response to a combination of itraconazole and terbinafine was noted, but owing to severe thrombocytopenia this combination was discontinued. Voriconazole was used but discontinued because of adverse side effects. Posaconazole treatment was offered throughout the clinical course but rejected owing to financial constraints and an uncertain response to medical therapy. Rhinotomy with debulking of diseased tissue and topical malachite green treatment was performed. Following the procedure itraconazole was continued and the cat has had no recurrence for over 1 year. Relevance and novel information Infections by Cladophialophora species have been reported in veterinary species, including cats. The specific fungal organism isolated from this cat has not been previously reported to cause disease in humans or animals and has only been described in the mangroves of Brazil. Furthermore, this is the first report to describe the use of topical malachite green as a treatment for refractory phaeohyphomycosis.
Morel-Lavallée lesions: a phenomenon in cats? Case report and review of the literature
Authors: McGhie Jayne A , Gibson Ian D , Herndon Aaron M 
Published: May 2018

Case summary A 3-year-old male neutered domestic shorthair cat sustained a severe sacrococcygeal luxation post-motor vehicle trauma. Six days post-trauma, a fluid-filled swelling was noticed over the caudoventral abdomen and inguinal regions. Needle aspiration, closed suction drain placement and debridement with subcutaneous tacking were all attempted but failed to resolve the continued accumulation of serosanguinous lymphocyte-rich fluid in the subcutaneous pocket. Clinical resolution was ultimately achieved after surgical debridement and omentalisation of the lesion. Relevance and novel information Morel-Lavallée lesions are post-trauma closed soft tissue degloving injuries described infrequently in people. The avulsion of subcutaneous tissue from deep muscle fascia results in the accumulation of haemolymph and necrotic fat, which can persist for several days to months after the inciting incident. In people, they are commonly seen in the proximal thigh. This article proposes the existence of Morel-Lavallée lesions in cats.
Oral Health Status and Treatment Needs among Intellectually Disabled in Madurai
Authors: Dheepthasri S. , Taranath M. , Garla Bharath Kumar , Karuppaiah Muthu , Umesh  , Sangeeta  
Published: May 2018

Aim: The aim of the study was to assess the oral health status and treatment needs among intellectually disabled (ID) people in Madurai city. Objectives: To evaluate the oral health status and treatment needs among ID people in Madurai city. Materials and Methods: A cross-sectional survey was conducted on 133 ID people obtaining training at special schools in Madurai. After obtaining the parental consent of the participants, oral health was assessed using World Health Organization (WHO) proforma 1997 and oral hygiene level was assessed using Simplified Oral Hygiene Index (OHI-S). Statistical analysis was done using Statistical Package for the Social Sciences (SPSS Inc., Chicago, IL, version 22.0 for Windows). Results: The result of the present study shows higher prevalence of oral problems in mentally retarded subjects with 31.6% periodontal disease, 49.6% dental caries, and 39.1% poor oral hygiene status, among the study participants. Conclusion: This study gives sufficient evidence to suggest that the oral health status of this disabled population was poor, and there was an increased unmet dental treatment needs.
Arthroscopic Treatment of Shoulder Instability With Glenoid Bone Loss Using Distal Tibial Allograft Augmentation: Safety Profile and Short-Term Radiological Outcomes
Authors: Amar Eyal , Konstantinidis George , Coady Catherine , Wong Ivan H. 
Published: May 2018

Background: The results of arthroscopic anterior labral repair have demonstrated high failure rates in patients with significant glenoid bone loss. Several reconstruction procedures using a bone graft have been developed to overcome bone loss. Purpose: The primary objective of this study was to generate a safety profile for arthroscopic anatomic glenoid reconstruction using a distal tibial allograft. The secondary objective was to evaluate the radiological outcomes of patients who underwent this procedure. Study Design: Case series; Level of evidence, 4. Methods: This retrospective review included the medical charts and diagnostic images of 42 consecutive patients who underwent arthroscopic shoulder stabilization by means of capsule-labral reattachment and bony augmentation with a distal tibial allograft. The safety profile was measured by detecting intraoperative or postoperative complications, including neurovascular (nerves and blood vessels) injuries, bleeding, infections, and dislocations. A radiological evaluation was conducted by assessing computed tomography (CT) scans obtained preoperatively and at approximately 6 months postoperatively. Results: A total of 42 patients (29 male, 13 female) with a mean age of 26.73 ± 9.01 years were included. An excellent safety profile was observed, with no intraoperative complications, neurovascular injuries, adverse events, bleeding, or infections. CT bone scans were obtained for 31 patients, and the mean follow-up for CT scanning (to measure resorption and union) was 6.31 ± 1.20 months (range, 6-7.5 months). There were no cases of nonunion or partial union. Thirteen patients (42%) had no resorption, whereas 13 (42%) and 5 (16%) patents had <50% and ≥50% resorption, respectively. Conclusion: Arthroscopic shoulder stabilization with distal tibial allograft reconstruction is a safe operative procedure with a minimal risk to neurovascular structures. Most patients had a healed allograft, but 16% of patients had ≥50% resorption on CT at 6 months. Studies with a longer follow-up are recommended for better assessment of the safety profile.
Allosteric Regulation of the Follicle-Stimulating Hormone Receptor
Authors: Nataraja Selvaraj , Sriraman Venkataraman , Palmer Stephen 
Published: May 2018

AbstractFollicle-stimulating hormone receptor (FSHR) belongs to the leucine-rich repeat family of the G protein–coupled receptor (LGR), which includes the glycoprotein hormone receptors luteinizing hormone receptor, thyrotropin receptor, and other LGRs 4, 5, 6, and 7. FSH is the key regulator of folliculogenesis in females and spermatogenesis in males. FSH elicits its physiological response through its cognate receptor on the cell surface. Binding of the hormone FSH to its receptor FSHR brings about conformational changes in the receptor that are transduced through the transmembrane domain to the intracellular region, where the downstream effector interaction takes place, leading to activation of the downstream signaling cascade. Identification of small molecules that could activate or antagonize FSHR provided interesting tools to study the signal transduction mechanism of the receptor. However, because of the nature of the ligand-receptor interaction of FSH-FSHR, which contains multiple sites in the extracellular binding domain, most of the small-molecule modulators of FSHR are unable to bind to the orthosteric site of the receptors. Rather they modulate receptor activation through allosteric sites in the transmembrane region. This review will discuss allosteric modulation of FSHR primarily through the discovery of small-molecule modulators, focusing on current data on the status of development and the utility of these as tools to better understand signaling mechanisms.
“That Abominable Solitary Vice We Call Theory”
Authors: Trujillo Kris 
Published: May 2018

AbstractOrganized around the complete works of John of the Cross, Juan Goytisolo’s Las virtudes del pájaro solitario (1988) presents a radical characterization of mysticism aligned with the spontaneity and immediacy of poetic genius. Through an elaboration of the opposition between critique and creation or theory and practice, Goytisolo aligns his version of mysticism with heresy and negative theology. But how might a return to John of the Cross’s writings wrest this “mystic” and “poet” from the confines of exceptionalism to rethink his exemplarity as grounded and cultivated in community? This article argues that reading John of the Cross’s Cántico espiritual in the context of the Carmelite reform not only destabilizes Goytisolo’s notion of radical mysticism but also makes imaginable a loving critique that offers the politics of queerness and religious difference an alternative to oppositionality per se.
Mystical Reflections on the Primordial Torah
Authors: Ish-Shalom Zvi 
Published: May 2018

Abstract
This essay examines select teachings from Kedumah, a contemporary mystical path in the lineage of the Primordial Torah. Kedumah, a Hebrew word that means “ancient” or “primordial,” points to the nonconceptual ground that eternally abides at the heart of all our experiences, prior to all the labeling and processing of our conceptual mind. The contemporary mystical path of Kedumah is interested in accessing and including this primordial nature as an integral part of our everyday experience. Kedumah thus calls for a more integrative appreciation of all reality—including the ordinary and mundane as equally sacred expressions of the whole. In this sense, Kedumah posits a mysticism that entails the normalization of the spiritual and the equalization of the sacred and profane. In this essay ancient Kabbalistic principles and biblical texts are examined to demonstrate this radical vision.
Jewish Mystical Influences on a Medieval Ottoman Hagiography
Authors: Durak Ahmet Cem 
Published: May 2018

Abstract
It has long been known that Muslim scholars used rabbinic literature in what is called Isra’iliyyat in the Islamic tradition. They used these sources as legitimate details of the Qur’anic stories. Less well known is how later Islamic scholars incorporated these sources into their own retellings of the stories that all three texts—the Qur’an, the Hebrew Bible, and the New Testament—share. This article examines the hagiography by Abdülvasi Çelebi (d. 1415), Halilname, which tells the story of Abraham and draws on rabbinic literature. Several factors led to the use of Jewish sources in Halilname. First, the Ottoman state did not have a canonized orthodox Islamic system until Süleyman I (r. 1520–66), and this lack of canonization gave Islamic mystics greater liberty to say what they wanted. Second, a zeitgeist of religious syncretism drew inspiration from the mysticism that dominated Anatolia. Finally, the most important patriarch for Jews, Christians, and Muslims—Abraham—proved the ideal subject in an empire that included members of all three monotheistic religions.
PEDF regulates plasticity of a novel lipid–MTOC axis in prostate cancer-associated fibroblasts
Authors: Nardi Francesca , Fitchev Philip , Franco Omar E. , Ivanisevic Jelena , Scheibler Adrian , Hayward Simon W. , Brendler Charles B. , Welte Michael A. , Crawford Susan E. 
Published: May 2018

ABSTRACT
Prostate tumors make metabolic adaptations to ensure adequate energy and amplify cell cycle regulators, such as centrosomes, to sustain their proliferative capacity. It is not known whether cancer-associated fibroblasts (CAFs) undergo metabolic re-programming. We postulated that CAFs augment lipid storage and amplify centrosomal or non-centrosomal microtubule-organizing centers (MTOCs) through a pigment epithelium-derived factor (PEDF)-dependent lipid–MTOC signaling axis. Primary human normal prostate fibroblasts (NFs) and CAFs were evaluated for lipid content, triacylglycerol-regulating proteins, MTOC number and distribution. CAFs were found to store more neutral lipids than NFs. Adipose triglyceride lipase (ATGL) and PEDF were strongly expressed in NFs, whereas CAFs had minimal to undetectable levels of PEDF or ATGL protein. At baseline, CAFs demonstrated MTOC amplification when compared to 1–2 perinuclear MTOCs consistently observed in NFs. Treatment with PEDF or blockade of lipogenesis suppressed lipid content and MTOC number. In summary, our data support that CAFs have acquired a tumor-like phenotype by re-programming lipid metabolism and amplifying MTOCs. Normalization of MTOCs by restoring PEDF or by blocking lipogenesis highlights a previously unrecognized plasticity in centrosomes, which is regulated through a new lipid–MTOC axis.
This article has an associated First Person interview with the first author of the paper.
МОДЕЛИРОВАНИЕ ТЕХНИЧЕСКИХ КАНАЛОВ УТЕЧКИ ИНФОРМАЦИИ НА РАСПРЕДЕЛЕННЫХ ОБЪЕКТАХ УПРАВЛЕНИЯ
Authors: Karpov Aleksander Vladimirovich , Lepeshkin Oleg Mikhailovich 
Published: May 2018

Значительное повышение требований к безопасности функционирования распределенных объектов управления не может быть реализовано только за счет расширения и ужесточения мер контроля за безопасностью. Первым шагом в обеспечении безопасности информации на таких объектах является анализ условий их функционирования и моделирование технических каналов утечки информации. Разработка моделей таких каналов по существу является единственным методом достаточно полного исследования их возможностей, и направлена на получение количественных оценок безопасности функционирования сложных объектов. Данные оценки необходимы для принятия решения о степени защищенности информации от утечки согласно действующему критерию. Существующие модели разработаны для типовых сосредоточенных объектов и позволяют оценить степень защищенности информации от утечки по каждому из каналов в отдельности, что влечет за собой значительное увеличение требуемого защитного ресурса и времени оценки защищенности информации на объекте в целом. В статье рассматривается логико-вероятностный метод оценки безопасности структурно-сложных объектов, на примере представлена модель канала утечки информации на распределенном объекте управления, рекомендовано использовать программный комплекс автоматизированного структурно-логического моделирования сложных систем, позволяющий оценить риск утечки информации в динамике. Рассчитывается вероятность утечки информации по техническим каналам, вычисляются такие дифференциальные характеристики безопасного функционирования распределенных объектов управления как положительные и отрицательные вклады инициирующих событий и условий, приводящих к утечке.Цель – количественная оценка риска утечки информации, необходимая для обоснования рационального состава организационно-технических мер защиты, а также варианта структуры системы защиты информации от утечки по техническим каналам.Метод или методология проведения работы: в статье использовался логико-вероятностный метод структурно-логического моделирования.Результаты: получены наиболее информативные параметры, позволяющие количественно оценить риск утечки информации.Область применения результатов: полученные результаты целесообразно применять для оценки безопасности функционирования структурно-сложных объектов, в том числе распределенных объектов управления, а также для рационального распределения сил и средств защиты информации от ее утечки по техническим каналам.