bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Idea of Nicaea at Ephesus II (449)
Authors: Smith Mark S. 
Published: December 2018

Abstract
At Ephesus II, the Nicene construal of 448 was overturned, Eutyches’ doctrine was declared to be faithful to Nicaea, and Flavian’s contrary to it. Ephesus II reoriented the reception of Ephesus I around the 22 July 431 acta (closing off the Antiochene strategy of reading Cyril’s council via the Formula of Reunion), whilst fashioning the hitherto little-known ‘Canon 7’ of 431 into a powerful weapon against any theological statements deemed to be an addition to the Nicene Creed. Ephesus II established its own conciliar status precisely by presenting its activity as the mere recapitulation and reapplication of the all-sufficient decrees of Nicaea and Ephesus. Moreover, the articulation of this ‘idea’ of Nicaea was primarily achieved through the careful layering of textual authorities in written conciliar acta. It was precisely though a self-consciously conservative re-presentation of the faith of Nicaea that Ephesus II dramatically remoulded the Nicene identity.
‘Good’ Bioethics
Authors: McMillan John 
Published: December 2018

Abstract
‘Good bioethics’ draws upon a range of approaches and does not privilege one theoretical or disciplinary perspective. It also aims at being ‘practical normative’ in the sense that it helps us find a way forward with moral issues. That requires a degree of empirical engagement and implies that good bioethics draws upon a range of disciplines and cannot be done from an armchair. Good bioethics is always typified by sound moral reason. That means it is Socratic in the sense that it seeks to test via argument the strength of moral claims, with the aim of finding well-justified moral conclusions. Moral reason admits of degrees; it is possible for someone to reason well or poorly, and the extent to which an instance of bioethics does either, contributes value or disvalue to it as bioethics.
ESTIMATION OF ORGAN DOSES AND EFFECTIVE DOSES BASED ON IN-PHANTOM DOSIMETRY FOR PAEDIATRIC DIAGNOSTIC CARDIAC CATHETERISATION
Authors: Kawasaki Toshio , Sakakubo Masami , Ito Kanako , Kitagawa Ai 
Published: December 2018

Abstract
The present study evaluated the organ doses, effective doses and conversion factors from the dose–area product to effective dose in pediatric diagnostic cardiac catheterization performed by in-phantom dosimetry and Monte Carlo simulation. The organ and effective doses in 5-y-olds during diagnostic cardiac catheterizations were evaluated using radiophotoluminescence glass dosemeters implanted into a pediatric anthropomorphic phantom and PCXMC software. The mean effective dose was 3.8 mSv (range: 1.8–7.5 mSv). The conversion factors from the dose–area product to effective dose were 0.9 and 1.6 mSv (Gy cm2)−1 for posteroanterior and lateral fluoroscopy, respectively, and 0.9 and 1.5 mSv (Gy cm2)−1 for posteroanterior and lateral cineangiography, respectively. Effective doses evaluated using the pediatric dosimetry system agreed with those obtained using PCXMC software within 12%. The dose data and conversion factors evaluated may guide the estimation of exposure doses in children undergoing diagnostic cardiac catheterization.
Predicted carcass meat yield and primal cut yields in cattle divergent in genetic merit for a terminal index
Authors: Connolly Stephen M , Cromie Andrew R , Sleator Roy D , Berry Donagh P 
Published: December 2018

Abstract
Several studies have clearly demonstrated the favorable impact of genetic selection on increasing beef cattle performance within the farm gate. Few studies, however, have attempted to quantify the value of genetic selection to downstream sectors of the beef industry, such as the meat processing sector. The objective of the current study was to characterize detailed carcass attributes of animals divergent in genetic merit for a terminal index as well as individual measures of genetic merit for carcass weight, conformation, and fat. The data used consisted of 53,674 young bulls and steers slaughtered between the years 2010 and 2013 in multiple Irish processing plants. All animals had a genetic evaluation as well as phenotypic measures of carcass characteristics. A terminal index, based on pedigree index for calving performance, feed intake, and carcass traits, calculated from the Irish national genetic evaluations, was obtained for each animal. Animals were categorized into four terminal index groups based on genetic merit estimates derived prior to the expression of the carcass phenotype by the animal. The association between genetic merit for terminal index with predicted phenotypic carcass red meat yield, carcass fat, carcass bone, and carcass composition, as well as between genetic merit for carcass weight, conformation, and fat with predicted phenotypic carcass red meat yield and composition were all quantified using linear mixed models. A greater terminal index value was associated with, on average, heavier phenotypic weights of each wholesale cut category. A greater terminal index value was also associated with a greater weight of meat and bone, but reduced carcass fat. Relative to animals in the lowest 25% genetic merit group, animals in the highest 25% genetic merit group had, on average, a greater predicted yield of very high value cuts (4.52 kg), high value cuts (13.13 kg), medium value cuts (6.06 kg), low value cuts (13.25 kg) as well as more total meat yield (37 kg). The results from the present study clearly signify a benefit to meat processers from breeding programs for terminal characteristics; coupled with the previously documented benefits to the producer, the benefits of breeding programs across the entire food production chain are obvious.
A 12-Year Experience of Hidradenitis Suppurativa Management
Authors: Vankevicčiūtė Rasa Aurelija , Polozovaitė Brigita , Trapikas Julius , Raudonis Tadas , Grigaitienė Jūratė , Bylaitė-Bucčinskienė Matilda 
Published: December 2018

ABSTRACT

BACKGROUND:
Although treatment recommendations for hidradenitis suppurativa (HS) are well known, practical experience implementing them in Lithuania has not been reported yet.

OBJECTIVE:
To review clinical findings and treatment options used in patients with HS in the largest center of dermatology and venereology in Lithuania from 2005 to 2016.

METHODS:
A retrospective single-center medical file analysis was conducted on 46 patients with HS. Demographic information, patient history, and treatment results were included in the final analysis. χ2 Tests were used. Statistical significance was set at P ≤ .05.

MAIN RESULTS:
Of the 46 patients, 52.2% were male. Percentages of patients with Hurley stages I, II, and III were 41.3%, 30.4%, and 28.3%, respectively. Patients with Hurley III HS were more likely to be smokers and obese. The most commonly prescribed medications were systemic antibiotics (76.1%) and systemic retinoids (37.0%). Systemic corticosteroids (19.6%) were more often prescribed to patients with Hurley III. Surgical procedures were performed in 54.3% of patients. The most common complication of the disease was contracture (13.0%).

CONCLUSIONS:
This study revealed an association between smoking and obesity and the most severe stage of HS. Results showed that traditional medications used in this study were not effective for severe HS.
Prospective Evaluation of Atrophic Acne Scars on the Face With Needle-Free High-Pressure Pneumatic Injection: Quantitative Volumetric Scar Improvement
Authors: Kim Bo Young , Chun Seung Hyun , Park Ji Hyun , Ryu Sook In , Kim Il-Hwan 
Published: December 2018

BACKGROUND
Atrophic acne facial scars still pose a treatment challenge. Needle-free high-pressure pneumatic injection has recently been introduced; however, few studies exist regarding its effectiveness.

OBJECTIVE
To evaluate the efficacy and safety of pneumatic injection for treating atrophic acne scars using a 3-dimensional optical profiling system.

METHODS AND MATERIALS
A pneumatic injection device with a 0.2-mm nozzle diameter, 50% pressure power, and 85-μL injection volume was used. The degree of depression was examined and analyzed using a 3-dimensional optical profiling system and clinical photographs. The patients also evaluated any side effects. Each subject underwent a single treatment session and was followed up after 1 and 2 months.

RESULTS
A total of 13 atrophic acne scars from 10 Korean men and women aged 20 to 29 (mean age 25.8 ± 2.4) years were studied. The mean scar volume values were 0.964, 0.741, and 0.566 mm3, respectively, at baseline, 1 month, and 2 months after the injection. Scar volumes after 2 months were significantly different compared with baseline volumes. However, there was no significant difference between the baseline and 1-month volumes.

CONCLUSION
Treatment with pneumatic injection is safe and effective in reducing atrophic acne facial scars; it results in quantitative improvement in scar volumes.
Histologic Effects of Fractional Laser and Radiofrequency Devices on Hyaluronic Acid Filler
Authors: Hsu Sarah Hahn , Chung Hye Jin , Weiss Robert A. 
Published: December 2018

BACKGROUND
Hyaluronic acid fillers (HAFs) and energy-based devices are frequently used sequentially. However, the effect of using fractional devices directly over HAF is unclear.

OBJECTIVE
To evaluate histologic changes after fractional laser and radiofrequency (RF) therapies applied over preinjected HAF.

MATERIALS AND METHODS
Abdominoplasty skin samples were divided into 8 zones. Intradermal injections of HAF were performed to 7 zones with 1 zone as untreated control. Six of 7 HAF injected zones were then treated with the following devices: 1,540-, 1,550-, 1927-, and 10,600-nm fractional lasers, and fractional bipolar RF delivered through insulated and noninsulated microneedles. After treatment, biopsies were collected for H&E staining.

RESULTS
Histology revealed HAF in the mid to deep dermis. Treatment with 1,540-, 1,550-, 1927-, and 10,600-nm lasers did not result in any morphologic changes of HAF, although thermal changes from 1,540- and 1,550-nm lasers were in very close proximity to the filler. The RF devices demonstrated thermal damage of HAF along the microneedle tracks.

CONCLUSION
Hyaluronic acid filler is unaffected by fractional lasers in this model. Fractional RF devices, which produce deeper dermal penetrations, will cause thermal damage of HAF. Caution is advised in using microneedle RF over recently injected filler. Study limitations include use of nonfacial skin and lack of inflammatory response in an ex-vivo model.
Research and development of safety management information system for neonatal bathroom and its clinical application
Authors: Wang Fang , Zhang Si-yu , Chen Jian-rong , Liu Ying-lei , Liu Man-hua , Xue Li-li , Wang Jian 
Published: December 2018

Abstract
We developed a bathroom safety management information system to decrease adverse nursing events, and observed the application of the self-developed safety management information system in neonatal bathroom.
A total of 3482 newborns receiving neonatal bath and rooming in between May 2015 and May 2017, were enrolled in this study. Of the 3482 newborns, 1727 that did not use the safety management information system from May 1, 2015 to May 31, 2016, were considered as control group; and other 1755 that used the safety management information system from June 1, 2016 to May 31, 2017 were entered in observation group. The accident rate of adverse nursing events, the duration to check wristbands, response time of urgency call, quantitative data recording for nursing procedures, and pregnant women's and their families’ satisfaction degree were compared between the 2 groups.
The management information system possesses 4 functions including personal identification, nursing operation quantification, monitoring alarm and music function, and guidance on specialized knowledge and skills. The accident rate of adverse nursing events was significantly lower in the observation than in the control group (P < .05). The duration to check wristbands and the response time of urgency call were all significantly shorter in the observation group than in the control group (all P < .05). Quantitative data recording was significantly better in the observation than in the control group (P < .05). Satisfaction degree was significantly higher in the observation group (96.47%) than in the control group (89.69%) (P < .05). The wireless transmission information was exact and safe, and the system was sensitive and reliable.
The system not only is clinically practical but also can enhance the safety of newborns and improve pregnant women's and their families’ satisfaction degree.
Utility of power Doppler ultrasonography for detecting forefoot bursae in early rheumatoid arthritis
Authors: Endo Yushiro , Koga Tomohiro , Eguchi Mizuna , Okamoto Momoko , Tsuji Sosuke , Takatani Ayuko , Shimizu Toshimasa , Sumiyoshi Remi , Igawa Takashi , Kawashiri Shin-ya , Iwamoto Naoki , Ichinose Kunihiro , Tamai Mami , Nakamura Hideki , Origuchi Tomoki , Kawakami Atsushi 
Published: December 2018

AbstractRationale:Power Doppler ultrasonography (PDUS) in musculoskeletal ultrasound (MSUS) is a sensitive and reliable method for the assessment of rheumatoid arthritis (RA). The association between ultrasound-detectable forefoot bursae and the development of RA has gained attention. However, a few studies have evaluated the utility of PDUS for examining forefoot bursae in early RA. We report the case of an RA patient who developed reduced foot mobility and had detectable intermetatarsal bursitis with remarkable power Doppler (PD) signals in MSUS at the onset of RA.Patient concerns:A 40-year-old Japanese woman diagnosed with palindromic rheumatism visited our department due to sustained forefoot pain and difficulty walking. The levels of both rheumatoid factor (RF) and anticitrullinated protein antibody (ACPA) were high. She had opening toes with swelling in metatarsophalangeal (MTP) joints. PDUS showed intermetatarsal bursitis with mild MTP synovitis.Diagnoses:We diagnosed RA by comprehensive judgment based on the 2010 American College of Rheumatology and European League Against Rheumatism classification criteria for RA.Interventions:We administered 6.0 mg/wk of methotrexate (MTX) and 2.0 mg/d of prednisolone (PSL) followed by an increase of MTX to 10 mg/wk.Outcomes:After those treatments, the patient's symptoms showed improvement. As of this writing, the patient's remission has been maintained for >2 months.Lessons:Her case suggests that PDUS is useful for the detection of forefoot bursitis, and the detection of forefoot bursitis by PDUS may provide the opportunity to make an early diagnosis of RA.
FBP2 and Talin-1 are potential protein markers for Mongolian medicine symptom evaluation in viral infectious diseases
Authors: Li Li , Wu Xiaoying , Eerdunchaolu  , Qin Wenyan , Yang Yuqiu , Wang Geriletu , He Huili , Zhang Husileng 
Published: December 2018

Abstract

Background:
Influenza, measles, and mumps are common viral infectious diseases in Mongolia. The traditional Mongolian medicine (TMM) classified them as warm disease, and still plays a major role in the diagnoses and treatments.

Methods:
To interpret the connotation of the complex theoretical system in TMM with scientific technique, in this study, a high throughput mass spectrometry was used to identify potential protein markers of TMM symptom types. Fifty venous blood samples were drawn from influenza, measles and mumps patients. Differential proteins between samples of patients diagnosed as immature and mature heat in TMM were detected by mass spectrometry.

Results:
After proteomics analysis, 1500 proteins and 7619 polypeptides were identified and 1323 in total showed differential expression between those 2 symptom types; then enrichment analysis of the differentially expressed proteins revealed the significant biological functions related to the differentially expressed proteins, including cardiomyopathy, several bacterial and parasitic infections, bacterial invasion of epithelial cells, insulin signaling pathway, and regulation of actin cytoskeleton. The network analysis showed that FBP2 and Talin-1 were critical points and might determine the evolution directions of TMM warm disease symptom.

Conclusions:
This study suggests that the identified core differential proteins may be regarded as potential biomarkers, and benefit to evaluate the evolutionary tendency of TMM warm disease symptoms.
Impact of metformin use on survival outcomes in non-small cell lung cancer treated with platinum
Authors: Wen-Xiu Xin , Xiao-Wei Zheng , Hai-Ying Ding , Ying-Hui Tong , Si-Si Kong , Xiao-Fang Zhou , Huang Ping 
Published: December 2018

Abstract
Preclinical evidence suggests that metformin, a widely used antidiabetic drug, may have a sensitizing effect on platinum. The purpose of this study was to evaluate the survival outcomes for non-small cell lung cancer (NSCLC) patients with type 2 diabetes mellitus (T2DM) using metformin during platinum-based chemotherapy.
The clinicopathological parameters and survival data of 75 NSCLC patients with T2DM from January 2008 to December 2011 were collected and analyzed retrospectively. Patients were divided into 2 groups: metformin exposure group (n = 27) and non-metformin group (patients using other hypoglycemic agents or no drug for controlling n = 48). Univariate and multivariate analyses were performed to assess the association of metformin usage with overall survival (OS).
Mean follow-up time was 58.7 months. The mean survival time was 36.74 months in the metformin group and 40.21 months in the non-metformin group. There was no significant difference in survival time between the 2 groups (P = .661). After adjusting gender, age, smoking status, tumor stage, tumor histology, and differentiation, multivariate analysis showed that metformin was not associated with the OS in NSCLC patients treated with concurrent platinum-based chemotherapy (hazard ratio: 1.071, 95% confidence interval: 0.577–1.986, P = .828).
Our results indicated that metformin exposure had no significant effect on OS in NSCLC patients treated with platinum-based chemotherapy. Further studies are warranted to evaluate whether metformin could affect the survival of NSCLC patients treated with platinum-based chemotherapy.
Congenital high airway obstruction with tracheoesophageal fistula
Authors: Wang Ying , Zhao Limin , Li Xiaoyan 
Published: December 2018

Abstract

Rationale:
Congenital high airway obstruction syndrome (CHAOS) is defined as complete or partial obstruction of the fetal upper airways. Laryngeal atresia is the most frequent cause.

Patient concern:
A male neonate born with poor reactions, weakly spontaneous breathing and cyanosis of the limbs was referred to our hospital.

Diagnosis:
CHAOS with tracheoesophageal fistula.

Intervention:
A tracheostomy was performed and a 3.0-mm internal diameter tracheostomy tube was inserted.

Outcomes:
Neonatal survival depended on our immediate postnatal intervention.

Lessons:
In summary, a multidisciplinary team including otolaryngologists, radiologists, obstetricians, and anesthesiologists must be present during the whole diagnosis and treatment process.
Meta-analysis of the effects of anti-epidermal growth factor receptor on recurrent/metastatic head and neck squamous cell carcinoma
Authors: Xin Yong , Yan Qiuyue , Yang ChunSheng , Jiang Fan , Guo Wenwen , Huang Qian , Jiang Guan , Zhang Longzhen 
Published: December 2018

Abstract

Background:
We performed a meta-analysis to compare the efficacy and safety of anti-epidermal growth factor receptor (EGFR) therapy and non-anti-EGFR therapy in recurrent/metastatic (RM) head and neck squamous cell carcinoma (HNSCC).

Methods:
The Cochrane library, WanFang Data, PubMed, Medline, VIP, CBM, and EBSCO databases were searched for relevant studies. The objective response rate (ORR, defined as complete response or partial response according to RECTST version 1.1) and grade 3 to 4 adverse effects were used.

Results:
Ten studies involving 2260 patients were included. Primary meta-analysis showed that anti-EGFR therapy improved the ORR [odds ratio (OR): 1.79, 95% confidence interval 1.44–2.21, P <.00001]. Subgroup analyses revealed that the ORR of patients with RM HNSCC could be improved by monoclonal antibodies (OR: 1.89, 1.46–2.45, P <.00001) and tyrosine kinase inhibitors (OR: 1.57, 1.07–2.31, P = .02). Analysis of grade 3 to 4 adverse effects demonstrated that diarrhea (3.15, [1.90, 5.20]), rash/desquamation (13.66, [6.86, 27.20]), hypomagnesemia (1.83, [1.28, 2.62]), vomiting (1.99, [1.00, 3.95]), anorexia (3.34, [1.45, 7.73]), dehydration (2.22, [1.19, 4.12]), and hypokalemia (1.63, [1.09, 2.42]) were significantly associated with anti-EGFR therapy.

Conclusion:
Anti-EGFR therapy is recommended for patients with RM HNSCC. Adverse effects, such as diarrhea, anorexia, hypomagnesemia, and hypokalemia, should be carefully monitored during anti-EGFR therapy.
Adult neuroblastoma in the retroperitoneum
Authors: Wu Xue-Liang , Dai Yong-Jun , Sun Guang-Yuan , Wang Li-Kun , Han Lei , Qu Ming , Liu Bo , Xue Jun 
Published: December 2018

Abstract

Rationale:
Neuroblastoma is the most common extracranial malignant solid tumor that occurs during childhood. It arises from primitive cells and is found in the adrenal medulla and sympathetic ganglia of the sympathetic nervous system. Huge neuroblastoma in the retroperitoneum, especially adult involvement is extremely rare.

Patient concerns:
A 20-year-old female patient with complaints of left abdominal discomfort for 1 week was reported.

Diagnosis:
Multi-detector computed tomography (MD-CT) of the abdomen revealed a huge enhanced mass in the retroperitoneum. Histopathological findings showed neuroblastoma and immunohistochemical results were as follows: actin(–), CD34(–), CD99(–), CK(–), CgA(+), desmin(–), EMA(–), Ki-67(+, approximately 1%), NSE(+), S-100(+), Syn(+), and vimentin(–).

Interventions:
We performed a total surgical resection. The CYVADIC (cyclophosphamide, vincristine, adriamycin, and dimethyl triazeno imidazole carboxamide) and James (cyclophosphamide and vincristine) regimens had been administered to this patient.

Outcomes:
Postoperatively, the patient's symptoms were partially relieved and the patient experienced recurrence after 3 months. The patient did not respond to treatment and died 6 months after the operation.

Lessons:
Besides surgical resection, the treatment also included chemotherapy and radiotherapy. However, the optimal treatment remains controversial. Therefore, we should exert all our energies on the exploration of etiology and targeted drugs for this disease.