bluuebunny/crossref_metadata_2025_split huggingface dataset:
Vaccines for emerging pathogens: prospects for licensure
Authors: Williamson E D , Westlake G E 
Published: April 2019

Summary
Globally, there are a number of emerging pathogens. For most, there are no licensed vaccines available for human use, although there is ongoing research and development. However, given the extensive and increasing list of emerging pathogens and the investment required to bring vaccines into clinical use, the task is huge. Overlaid on this task is the risk of anti-microbial resistance (AMR) acquisition by micro-organisms which can endow a relatively harmless organism with pathogenic potential. Furthermore, climate change also introduces a challenge by causing some of the insect vectors and environmental conditions prevalent in tropical regions to begin to spread out from these traditional areas, thus increasing the risk of migration of zoonotic disease.
Vaccination provides a defence against these emerging pathogens. However, vaccines for pathogens which cause severe, but occasional, disease outbreaks in endemic pockets have suffered from a lack of commercial incentive for development to a clinical standard, encompassing Phase III clinical trials for efficacy. An alternative is to develop such vaccines to request US Emergency Use Authorization (EUA), or equivalent status in the United States, Canada and the European Union, making use of a considerable number of regulatory mechanisms that are available prior to licensing. This review covers the status of vaccine development for some of the emerging pathogens, the hurdles that need to be overcome to achieve EUA or an equivalent regional or national status and how these considerations may impact vaccine development for the future, such that a more comprehensive stockpile of promising vaccines can be achieved.
Introduction pathways and socio‐economic variables drive the distribution of alien amphibians and reptiles in a megadiverse country
Authors: Fonseca Érica , Both Camila , Cechin Sonia Zanini 
Published: April 2019

AbstractAimsWe identify alien reptiles and amphibians, invaders or not, in Brazil and evaluate the following: (a) which alien species are found in the country; (b) where they originate from; (c) how they are distributed; (d) why and how they were introduced; and (e) which factors affect the record incidences and local richness of these species.LocationBrazil.MethodsWe conduct a comprehensive survey of different data sources to collect records of alien amphibians and reptiles. We then use a causal model approach to evaluate the influence of space, climate, anthropogenic predictors, and introduction pathways on alien richness and number of records.ResultsWe find a total of 2,292 records of 136 species of alien reptiles and amphibians. Although species from many regions of the world can be found, most are snakes, lizards and anurans originating in the Americas. Although records of alien amphibians and reptiles are found throughout Brazil, they are concentrated in more economically developed areas. Socio‐economic measures have both a direct and indirect causal relationship over the distribution of alien species and affect all introduction pathways, which are key factors explaining the alien species’ distribution. Pet trade was directly related to alien diversity, while all the three introduction pathways contributed to explain the number of records.Main ConclusionsWe reveal a high diversity of alien amphibians and reptiles widespread in an already megadiverse country. The finding that alien richness occurs in highly populated and wealthy areas and that it is linked to the pet trade helps to direct efforts towards the surveillance and prevention of the spread of alien species in Brazil. A higher record incidence is associated with species introduced accidentally or for human consumption, mainly represented by a few already invasive widespread species, impairing management measures.
From Getting the Development Question Wrong to Bringing Emancipation Back In: Re‐reading Alice Amsden
Authors: Song Hae‐Yung 
Published: April 2019

ABSTRACTThis article appraises Alice Amsden's theory of development. In particular, it focuses on Amsden's juxtaposing of the concrete and the universal, and the national and the global, as antithetical, and her prioritizing of the former over the latter. The author argues that this key feature of Amsden's work reduces the concept of development to a nationally determined process and empties capitalist development of its class content. It is argued that Amsden's primary focus on why and how development occurs in the Third World bypasses the question of what development is, thereby reinforcing ‘Third World developmentalism’, and removes the emancipatory content from the concept of development. Given the continued legacy of Amsden's theory, as evidenced in recent debates, and the inadequacy of extant Marxist critiques in addressing its conceptual and political problems, this article proposes an alternative conceptualization of concrete–general and national–global relations based on Marx's critique of political economy, and calls for the resuscitation of the emancipatory content of the concept of development.
Nurturing care framework for inclusive early childhood development: opportunities and challenges
Authors: Wertlieb Donald 
Published: April 2019

The nurturing care framework (NCF) for early childhood development (ECD) launched at the 2018 World Health Assembly opens a range of opportunities and challenges for child neurodisability professionals. The United Nations Convention on the Rights of the Child and Convention on the Rights of People with Disabilities frame these pathways for collaboration and progress. This overview of the NCF and its contexts in inclusive ECD identifies avenues for innovation and collaboration in harmony with the field's clinical, scientific, and advocacy agendas. One avenue involves enhancing the alignment between health systems and human rights. A second avenue involves neurodisability professionals engaging with nurturing care as leaders, partners, and implementers.What this paper adds

Participation and leadership by neurodisability professionals can enhance quality and impact.

A rights‐based framework that includes young children with disabilities and their families is widely encouraged.
Neurofilament light chain levels in pregnant multiple sclerosis patients: a prospective cohort study
Authors: Cuello J. P. , Martínez Ginés M. L. , Kuhle J. , García Domínguez J. M. , Lozano Ros A. , Romero Delgado F. , Higueras Y. , Meldaña Rivera A. , Goicochea Briceño H. , García‐Tizon Larroca S. , De León-Luis J. , Michalak Z. , Barro C. , Álvarez Lafuente R. , Medina Heras S. , Fernández Velasco J. I. , Tejeda‐Velarde A. , Domínguez‐Mozo M. I. , Muriel A. , de Andrés C. , Villar L. M. 
Published: April 2019

Background and purposeNeurofilament light chain is a cytoskeletal protein of neurons. Its levels are increasingly recognized as measures of neuroaxonal damage. The aim of this study was to explore serum neurofilament light chain (sNfL) levels in multiple sclerosis (MS) patients and healthy controls during pregnancy and puerperium.MethodsThis was a prospective, longitudinal, single‐center study. sNfL concentration was assessed using a highly sensitive single‐molecule array during pregnancy and in puerperium, in a cohort of 39 pregnant patients with relapsing multiple sclerosis (P‐MS). Twenty‐one healthy pregnant women (HPW) served as a control group. Eight P‐MS suffered relapses during pregnancy (P‐MS‐R) in the first or second trimesters.ResultsNo differences in pregnancy and delivery data were observed between P‐MS and HPW. P‐MS showed higher sNfL values than HPW in the first trimester, independently of the presence (P = 0.002) or not (P = 0.02) of relapses during pregnancy. However, in the third trimester, only P‐MS‐R showed higher sNfL values than HPW (P = 0.001). These differences extended to the puerperium, where P‐MS‐R showed higher sNfL values than those with no relapses during gestation (P = 0.02).ConclusionThese data strongly suggest that sNfL levels reflect MS activity during pregnancy. Additionally, the absence of relapses during pregnancy may have a beneficial effect on neurodegeneration during puerperium.
Macrophytes in tropical shallow lakes: An important food item to benthic entomofauna or an underused resource?
Authors: Shimabukuro Erika M. , Henry Raoul 
Published: April 2019

AbstractAlthough macrophytes are known to increase benthic diversity in lakes, the importance of this resource as food for the insects living at the bottom of these ecosystems are still poorly understood. This study assessed the diets of benthic Chironomidae and Campsurus (Ephemeroptera) in two environments: a lake with macrophytes (M+) and another without macrophytes (M−). We expected a differential use of food resources in M+, where plant tissue is particularly important for the aquatic insects’ diet. The diet of 734 individuals from 16 taxa were analyzed. Contrary to expectations, benthic insects consumed low amounts of plant tissue. This finding led us to investigate whether the presence of macrophytes in lakes would indirectly contribute to the benthic insects’ feeding, as more food resources were explored in M+ and a spatial variation of resources intake was observed in this lake, in contrast to the homogeneous feeding in M−. We highlight that macrophytes were responsible for the organic matter build‐up in the sediment, especially at the lake region dominated by these plants, and contributed to increase the deposition of high‐quality amorphous organic matter, which favored taxa in M+ that fed exclusively on this item. The lower diversity of food items exploited in M−, and the Tanypus alga‐based diet in this lake, indicates the low quality of organic resources in its sediment. Although macrophytes were indirectly beneficial for benthic insects’ feeding, we found that this is not an attractive resource for prompt ingestion by most benthic taxa.
Epilepsy and seizures in young people with 22q11.2 deletion syndrome: Prevalence and links with other neurodevelopmental disorders
Authors: Eaton Christopher B. , Thomas Rhys H. , Hamandi Khalid , Payne Gareth C. , Kerr Michael P. , Linden David E. J. , Owen Michael J. , Cunningham Adam C. , Bartsch Ullrich , Struik Siske S. , van den Bree Marianne B. M. 
Published: April 2019

SummaryObjectiveThe true prevalence of epileptic seizures and epilepsy in 22q11.2 deletion syndrome (22q11.2DS) is unknown, because previous studies have relied on historical medical record review. Associations of epilepsy with other neurodevelopmental manifestations (eg, specific psychiatric diagnoses) remain unexplored.MethodsThe primary caregivers of 108 deletion carriers (mean age 13.6 years) and 60 control siblings (mean age 13.1 years) completed a validated epilepsy screening questionnaire. A subsample (n = 44) underwent a second assessment with interview, prolonged electroencephalography (EEG), and medical record and epileptologist review. Intelligence quotient (IQ), psychopathology, and other neurodevelopmental problems were examined using neurocognitive assessment and questionnaire/interview.ResultsEleven percent (12/108) of deletion carriers had an epilepsy diagnosis (controls 0%, P = 0.004). Fifty‐seven of the remaining 96 deletion carriers (59.4%) had seizures or seizurelike symptoms (controls 13.3%, 8/60, P < 0.001). A febrile seizure was reported for 24.1% (26/107) of cases (controls 0%, P < 0.001). One deletion carrier with a clinical history of epilepsy was diagnosed with an additional type of unprovoked seizure during the second assessment. One deletion carrier was newly diagnosed with epilepsy, and two more with possible nonmotor absence seizures. A positive screen on the epilepsy questionnaire was more likely in deletion carriers with lower performance IQ (odds ratio [OR] 0.96, P = 0.018), attention‐deficit/hyperactivity disorder (ADHD) (OR 3.28, P = 0.021), autism symptoms (OR 3.86, P = 0.004), and indicative motor coordination disorder (OR 4.56, P = 0.021).SignificanceEven when accounting for deletion carriers diagnosed with epilepsy, reports of seizures and seizurelike symptoms are common. These may be “true” epileptic seizures in some cases, which are not recognized during routine clinical care. Febrile seizures were far more common in deletion carriers compared to known population risk. A propensity for seizures in 22q11.2DS was associated with cognitive impairment, psychopathology, and motor coordination problems. Future research is required to determine whether this reflects common neurobiologic risk pathways or is a consequence of recurrent seizures.
Marine heatwaves reveal coral reef zones susceptible to bleaching in the Red Sea
Authors: Genevier Lily G. C. , Jamil Tahira , Raitsos Dionysios E. , Krokos George , Hoteit Ibrahim 
Published: April 2019

AbstractAs the Earth's temperature continues to rise, coral bleaching events become more frequent. Some of the most affected reef ecosystems are located in poorly monitored waters, and thus, the extent of the damage is unknown. We propose the use of marine heatwaves (MHWs) as a new approach for detecting coral reef zones susceptible to bleaching, using the Red Sea as a model system. Red Sea corals are exceptionally heat‐resistant, yet bleaching events have increased in frequency. By applying a strict definition of MHWs on >30 year satellite‐derived sea surface temperature observations (1985–2015), we provide an atlas of MHW hotspots over the Red Sea coral reef zones, which includes all MHWs that caused major coral bleaching. We found that: (a) if tuned to a specific set of conditions, MHWs identify all areas where coral bleaching has previously been reported; (b) those conditions extended farther and occurred more often than bleaching was reported; and (c) an emergent pattern of extreme warming events is evident in the northern Red Sea (since 1998), a region until now thought to be a thermal refuge for corals. We argue that bleaching in the Red Sea may be vastly underrepresented. Additionally, although northern Red Sea corals exhibit remarkably high thermal resistance, the rapidly rising incidence of MHWs of high intensity indicates this region may not remain a thermal refuge much longer. As our regionally tuned MHW algorithm was capable of isolating all extreme warming events that have led to documented coral bleaching in the Red Sea, we propose that this approach could be used to reveal bleaching‐prone regions in other data‐limited tropical regions. It may thus prove a highly valuable tool for policymakers to optimize the sustainable management of coastal economic zones.
Grass silage for biorefinery—A meta‐analysis of silage factors affecting liquid–solid separation
Authors: Franco Marcia , Hurme Timo , Winquist Erika , Rinne Marketta 
Published: April 2019

AbstractThis meta‐analysis based on 19 studies from Finland comprising 43 grass silages was undertaken to evaluate the effect of silage quality on liquid yield, liquid composition and retained compounds in liquid using four different liquid–solid separation methods. Silages were classified according to species (grass, clover or a mixture of them), additive treatment (no, biological or formic acid‐based additive) and harvest (primary growth or regrowth). A mixed model regression analysis with random study effect was used to evaluate the impact of silage characteristics on biorefinery efficiency. There was a large variation in silage quality in the data set. Silage dry‐matter concentration was the characteristic most highly correlated with liquid yield for all separation methods, and when used as an independent variable in the model, it resulted in the best predictions. The liquid–solid separation methods presented a great variation in the liquid yield, ranging from 0.26 to 0.56 when silage dry‐matter concentration was standardized to 250 g/kg. There was no effect of additive treatment and harvest in the estimation of the biorefinery potential, but species was a significant variable in predicting liquid yield for the laboratory‐scale presses with higher liquid yield for mixed grass and legume. The high correlation between silage quality and liquid yield and liquid composition provides potential to predict the biorefinery potential based on equations developed for each separation method. This information can be used to modify the silage production systems so that they best meet the requirements of a green biorefinery process.
Branched chain amino acids are associated with the heterogeneity of the area of lipid droplets in hepatocytes of patients with non‐alcoholic fatty liver disease
Authors: Kakazu Eiji , Sano Akitoshi , Morosawa Tatsuki , Inoue Jun , Ninomiya Masashi , Iwata Tomoaki , Nakamura Takuya , Takai Satoshi , Sawada Shojiro , Katagiri Hideki , Shimosegawa Tooru , Masamune Atsushi 
Published: April 2019

AimMacrovesicular steatosis around the central vein (zone 3) is one of the pathological features of non‐alcoholic fatty liver disease or steatohepatitis (NAFLD/NASH). The aim of this study is to elucidate precisely the association between the area of lipid droplets (LDs) and the plasma metabolic parameters in patients with NAFLD/NASH.MethodsEighty patients with NAFLD/NASH diagnosed by needle biopsy were enrolled. The LDs around zone 3 were counted automatically by image processing software, the total area of LDs (TLDs), the maximum area of LDs (MAXLDs), the average area of LDs (AVELDs) and the heterogeneity by the coefficient of variation (CV [%]) were quantified. The correlations between these values and plasma metabolic parameters were analyzed. We evaluated the association between branched chain amino acids (BCAAs) and the heterogeneity of LDs in hepatocytes in vitro and in vivo.ResultsThe MAXLDs was significantly correlated with more metabolic parameters than AVELDs and TLDs. The level of BCAAs was independently associated with the CV among the metabolic parameters. In early stage NAFLD, aspartate and alanine aminotransferase were significantly higher in the high CV group than in the low CV group. The high concentration of BCAAs increased the CV of LDs in hepatocytes accompanied by the expression of phosphor‐p70 S6 kinase and sterol regulatory element‐binding protein 1 in vitro. A high BCAA diet induced high heterogeneity of LDs around zone 3 in ob/ob mice.ConclusionsThe levels of BCAAs were associated with the LD heterogeneity of hepatocytes around zone 3 in patients with NAFLD/NASH.
Regulation of global CD8+ T‐cell positioning by the actomyosin cytoskeleton
Authors: Stein Jens V. , Ruef Nora 
Published: April 2019

SummaryCD8+ T cells have evolved as one of the most motile mammalian cell types, designed to continuously scan peptide–major histocompatibility complexes class I on the surfaces of other cells. Chemoattractants and adhesion molecules direct CD8+ T‐cell homing to and migration within secondary lymphoid organs, where these cells colocalize with antigen‐presenting dendritic cells in confined tissue volumes. CD8+ T‐cell activation induces a switch to infiltration of non‐lymphoid tissue (NLT), which differ in their topology and biophysical properties from lymphoid tissue. Here, we provide a short overview on regulation of organism‐wide trafficking patterns during naive T‐cell recirculation and their switch to non‐lymphoid tissue homing during activation. The migratory lifestyle of CD8+ T cells is regulated by their actomyosin cytoskeleton, which translates chemical signals from surface receptors into mechanical work. We explore how properties of the actomyosin cytoskeleton and its regulators affect CD8+ T cell function in lymphoid and non‐lymphoid tissue, combining recent findings in the field of cell migration and actin network regulation with tissue anatomy. Finally, we hypothesize that under certain conditions, intrinsic regulation of actomyosin dynamics may render NLT CD8+ T‐cell populations less dependent on input from extrinsic signals during tissue scanning.
Resolving the (Apparent) Talker Recognition Paradox in Developmental Speech Perception
Authors: Fecher Natalie , Paquette‐Smith Melissa , Johnson Elizabeth K. 
Published: April 2019

The infant literature suggests that humans enter the world with impressive built‐in talker processing abilities. For example, newborns prefer the sound of their mother's voice over the sound of another woman's voice, and well before their first birthday, infants tune in to language‐specific speech cues for distinguishing between unfamiliar talkers. The early childhood literature, however, suggests that preschoolers are unable to learn to identify the voices of two unfamiliar talkers unless these voices are highly distinct from one another, and that adult‐level talker recognition does not emerge until children near adolescence. How can we reconcile these apparently paradoxical messages conveyed by the infant and early childhood literatures? Here, we address this question by testing 16.5‐month‐old infants (N = 80) in three talker recognition experiments. Our results demonstrate that infants at this age have difficulty recognizing unfamiliar talkers, suggesting that talker recognition (associating voices with people) is mastered later in life than talker discrimination (telling voices apart). We conclude that methodological differences across the infant and early childhood literatures—rather than a true developmental discontinuity—account for the performance differences in talker processing between these two age groups. Related findings in other areas of developmental psychology are discussed.
Epidemiology and outcomes of hospitalized adults with respiratory syncytial virus: A 6‐year retrospective study
Authors: Schmidt Henry , Das Arighno , Nam Hannah , Yang Amy , Ison Michael G. 
Published: April 2019

ObjectivesRespiratory syncytial virus (RSV) is an important cause of morbidity and mortality in adults. Existing studies are limited by the number of seasons studied and most have focused on the immunocompromised.MethodsA retrospective cohort study was conducted on all adults (≥18 years) with a positive RSV molecular test admitted from 2009 to 2015 to one hospital in Chicago, IL. Epidemiologic and outcomes data were collected after IRB approval.ResultsOf the 489 eligible patients, 227 had RSV A and 262 had RSV B. Patients had a median age of 61 years and comorbidity (eg, chronic lung disease [40.6%], obesity [37.8%], and cardiac disease [34.3%]). On presentation, most had cough (86.5%), fever (42.4%), and shortness of breath (38.2%). Severe disease was present in 27.6% of patients. Antibiotic was used in 76.3% inpatients and 45.8% at discharged despite few patients (4.7%) having documented bacterial infections. Supplemental oxygen and mechanical ventilation were utilized in 44.6% and 12.3%, respectively, while ICU level care was required in 26.9%. Most patients were discharged home (82.7%). Most deaths (68.4%, 13/19) were attributed to pneumonia or hypoxemia likely from RSV. Most fatal cases were seen in those with recent cancer treatment and older adults.ConclusionsRespiratory syncytial virus in hospitalized adults is associated with significant morbidity and mortality with 26.9% requiring ICU level care. Antibiotics are commonly prescribed to patients with documented RSV, and antibiotics are frequently continued after diagnosis. Novel antiviral therapies are needed for RSV to improve outcomes and potentially improve antibiotic stewardship in patients without a bacterial infection.