bluuebunny/crossref_metadata_2025_split huggingface dataset:
Origins Space Telescope: Predictions for far-IR spectroscopic surveys
Authors: Bonato Matteo , De Zotti Gianfranco , Leisawitz David , Negrello Mattia , Massardi Marcella , Baronchelli Ivano , Cai Zhen-Yi , Bradford Charles M. , Pope Alexandra , Murphy Eric J. , Armus Lee , Cooray Asantha 
Published: April 2019

AbstractWe illustrate the extraordinary potential of the (far-IR) Origins Survey Spectrometer (OSS) on board the Origins Space Telescope (OST) to address a variety of open issues on the co-evolution of galaxies and AGNs. We present predictions for blind surveys, each of 1000 h, with different mapped areas (a shallow survey covering an area of 10 deg2 and a deep survey of 1 deg2) and two different concepts of the OST/OSS: with a 5.9 m telescope (Concept 2, our reference configuration) and with a 9.1 m telescope (Concept 1, previous configuration). In 1 000 h, surveys with the reference concept will detect from ∼1.9×106 to ∼8.7×106 lines from ∼4.8×105 to 2.7×106 star-forming galaxies and from ∼1.4×104 to ∼3.8×104 lines from ∼1.3×104 to 3.5×104 AGNs. The shallow survey will detect substantially more sources than the deep one; the advantage of the latter in pushing detections to lower luminosities/higher redshifts turns out to be quite limited. The OST/OSS will reach, in the same observing time, line fluxes more than one order of magnitude fainter than the SPICA/SMI and will cover a much broader redshift range. In particular it will detect tens of thousands of galaxies at z ≥ 5, beyond the reach of that instrument. The polycyclic aromatic hydrocarbons lines are potentially bright enough to allow the detection of hundreds of thousands of star-forming galaxies up to z ∼ 8.5, i.e. all the way through the reionisation epoch. The proposed surveys will allow us to explore the galaxy–AGN co-evolution up to z ∼ 5.5−6 with very good statistics. OST Concept 1 does not offer significant advantages for the scientific goals presented here.
The effect of speech rhythm and speaking rate on assessment of pronunciation in a second language
Authors: Polyanskaya Leona , Ordin Mikhail 
Published: April 2019

AbstractThe study explores the effect of deviations from native speech rhythm and rate norms on the assessement of pronunciation mastery of a second language (L2) when the native language of the learner is either rhythmically similar to or different from the target language. Using the concatenative speech synthesis technique, different versions of the same sentence were created in order to produce segmentally and intonationally identical utterances that differed only in rhythmic patterns and/or speaking rate. Speech rhythm and tempo patterns modeled those from the speech of French or German native learners of English at different proficiency levels. Native British English speakers rated the original sentences and the synthesized utterances for accentedness. The analysis shows that (a) differences in speech rhythm and speaking tempo influence the perception of accentedness; (b) idiosyncratic differences in speech rhythm and speech rate are sufficient to differentiate between the proficiency levels of L2 learners; (c) the relative salience of rhythm and rate on perceived accentedness in L2 speech is modulated by the native language of the learners; and (d) intonation facilitates the perception of finer differences in speech rhythm between otherwise identical utterances. These results emphasize the importance of prosodic timing patterns for the perception of speech delivered by L2 learners.
Turmeric and chicory seed have beneficial effects on obesity markers and lipid profile in non-alcoholic fatty liver disease (NAFLD)
Authors: Ghaffari Aida , Rafraf Maryam , Navekar Roya , Sepehri Bita , Asghari-Jafarabadi Mohammad , Ghavami Seyyed-Mostafa 
Published: April 2019

Abstract. In an attempt to investigate new strategies aimed at reducing risk factors of non-alcoholic fatty liver disease (NAFLD), effects of turmeric (Curcuma longa L.) and chicory seed (Cichorium intybus L.) supplementation was evaluated in these patients. In this double-blind, randomized, controlled clinical trial, 92 patients with NAFLD aged 20–60 year with body mass index (BMI) ranged 24.9–40 kg/m2was randomly assigned to 4 groups as follows. 1) Turmeric supplementation (3 g/d) (n = 23, TUR); 2) Chicory seed supplementation (infused 9 g/d (4.5 g /100mL)) (n = 23, CHI); 3) Turmeric and chicory seed supplementation (3 g/d turmeric + infused 9 g/d chicory seed (n = 23, TUR + CHI); 4) Placebo (n = 23, PLA). All intervention periods were 12 weeks. Fasting blood samples, anthropometric measurements, dietary records and physical activity were collected at baseline and at the end of the trial. Significant decreases were observed in BMI and waist circumference (WC) of subjects in CHI and TUR + CHI groups, compared with PLA group (p < 0.05). Combination of turmeric and chicory seed significantly decreased serum alkaline phosphatase level (p < 0.05). Serum levels of HDL-C increased considerably in TUR and TUR + CHI groups (p < 0.05 vs. placebo). Turmeric supplementation alone and plus chicory seed led to significant reduction in serum levels of TG/HDL-C and LDL-C/HDL-C ratio in TUR and TUR + CHI groups in comparison with placebo (p < 0.05). In conclusion, turmeric and chicory seed supplementation can be significantly useful in management of NAFLD risk factors.
Basin‐Scale Variations in Labile Dissolved Phosphoric Monoesters and Diesters in the Central North Pacific Ocean
Authors: Yamaguchi Tamaha , Sato Mitsuhide , Hashihama Fuminori , Ehama Makoto , Shiozaki Takuhei , Takahashi Kazutaka , Furuya Ken 
Published: April 2019

AbstractLabile dissolved phosphoric esters act as important phosphorus sources for microorganisms in the low‐phosphate oligotrophic ocean. Despite the significant role of labile dissolved phosphoric esters, previous studies have only focused on phosphoric monoesters, and the spatial distribution and dynamics of phosphoric ester species, including diesters, remain unclear. Thus, we aimed to elucidate basin‐scale variations in both monoesters and diesters and their role on microorganisms particularly in terms of diazotrophs. This is the first study to report the concentrations of these phosphoric esters in low‐ to middle‐latitudinal areas of the central North Pacific Ocean, concurrent with their hydrolysis rates. Hydrolysable monoester and diester concentrations ranged from undetectable levels to 40 nM, and their sum accounted for <11% of dissolved organic phosphorus on average. While monoester concentrations were significantly low in the low phosphate (<100 nM) region, there was no obvious trend between diester and phosphate concentrations. Monoesterase and diesterase activities showed significantly high values under low phosphate conditions when normalized by chlorophyll a concentrations. This indicated that both esters served as alternative phosphorus sources for microbial communities including phytoplankton. Diester concentrations and diesterase activities were positively correlated with nitrogen fixation activities, whereas such relationships were not observed for monoester concentrations and monoesterase activities. Thus, our results suggest that diesters have high affinity to diazotrophs compared with monoesters, which are utilized by a broad spectrum of microorganisms.
Reduced Moisture Transport Linked to Drought Propagation Across North America
Authors: Herrera‐Estrada Julio E. , Martinez J. Alejandro , Dominguez Francina , Findell Kirsten L. , Wood Eric F. , Sheffield Justin 
Published: April 2019

AbstractDroughts can have devastating societal impacts. Yet, we do not fully understand the mechanisms that control their development, possibly affecting our ability to predict them. Here we run a moisture‐tracking analytical model using reanalysis data between 1980 and 2016 to explore the role of reduced moisture transport in drought propagation. We find that agricultural droughts in multiple subregions across North America may be amplified by decreased moisture transport from upwind land areas, which we link to reduced evapotranspiration and dry soil moisture upwind. We also find that decreases in precipitation recycling are correlated with decreases in moisture arriving from upwind areas. We estimate that decreases in moisture contributions from land areas accounted for 62% of the precipitation deficit during the 2012 Midwest drought. Our results suggest that the land surface may contain useful information for drought prediction and highlight the importance of sustainable land use and of regional cooperation for drought risk management.
Polyaromatic nanocapsules as photoresponsive hosts in water
Authors: Catti Lorenzo , Kishida Natsuki , Kai Tomokuni , Akita Munetaka , Yoshizawa Michito 
Published: April 2019

AbstractMolecular containers that provide both stimuli-responsive assembly/disassembly properties and wide-ranging host capabilities in aqueous medium still remain a current synthetic challenge. Herein we report polyaromatic nanocapsules assembled from V-shaped amphiphilic molecules bearing a photoresponsive ortho-dianthrylbenzene unit in water. Unlike previously reported supramolecular capsules and cages, the nanocapsules quickly and quantitatively disassemble into monomeric species by a non-invasive light stimulus through structural conversion from the open to the closed form of the amphiphiles. Regeneration of the nanocapsules is demonstrated by light irradiation or heating of the closed amphiphiles. With the aid of the wide-ranging host capability, the photo-induced release of various encapsulated guest molecules (e.g., Nile red, Cu(II)-phthalocyanine, and fullerene C60) can be achieved by using the present nanocapsule in water. This feature can furthermore be utilized to switch the fluorescence of encapsulated coumarin guests through their controlled release.
Bacillus subtilis CBR05 induces Vitamin B6 biosynthesis in tomato through the de novo pathway in contributing disease resistance against Xanthomonas campestris pv. vesicatoria
Authors: Chandrasekaran Murugesan , Paramasivan Manivannan , Chun Se-Chul 
Published: April 2019

AbstractExpression profiling for genes involved in Vitamin B6 (VitB6) biosynthesis was undertaken to delineate the involvement of de novo and salvage pathway induced by Bacillus subtilis CBR05 against, Xanthomonas campestris pv. vesicatoria in tomato. Pyridoxine biosynthesis (PDX) genes such as PDX1.2 and PDX1.3, were found to be overexpressed significantly at 72 hpi in B. subtilis and pyridoxine inoculated plants. Most significant upregulation was observed in the transcript profile of PDX1.3, which showed more than 12- fold increase in expression. Unfortunately, salt sensitive overlay4 (SOS4) profiling showed irregular expression which corroborates that SOS4 role in VitB6 biosynthesis needs further studies for deciphering a clear notion about their role in tomato. Antioxidant enzymes i.e., superoxide dismutase, catalase, polyphenol oxidase, and peroxidase activities clearly demonstrate escalation till 48 hpi and gets reduced in 72 hpi. Pot trials also confirm that B. subtilis compared to pyridoxine supplementation alone show plant disease resistance and elongated roots. The present study confirms that B. subtilis, as a versatile agent in eliciting induced systemic resistance regulated by de novo pathway as a model for plant defense against X. campestris pv. vesicatoria substantiated by VitB6 biosynthesis. Nevertheless, the study is preliminary and needs further evidence for affirming this phenomenon.
Knee osteoarthritis induces atrophy and neuromuscular junction remodeling in the quadriceps and tibialis anterior muscles of rats
Authors: Cunha Jonathan Emanuel , Barbosa Germanna Medeiros , Castro Paula Aiello Tomé de Souza , Luiz Beatriz Leite Ferreira , Silva Andreza Cristine Arcari , Russo Thiago Luiz , Vasilceac Fernando Augusto , Cunha Thiago Mattar , Cunha Fernando Queiróz , Salvini Tania Fátima 
Published: April 2019

AbstractKnee osteoarthritis (KOA) is associated with muscle weakness, but it is unclear which structures are involved in the muscle changes. This study assessed morphological alterations and the expression of genes and proteins linked to muscular atrophy and neuromuscular junctions (NMJs) in KOA, induced by anterior cruciate ligament transection (ACLT) in rats. Two groups of rats were assessed: control (without intervention) and KOA (ACLT surgery in the right knee). After 8 weeks, quadriceps, tibialis anterior (TA) and gastrocnemius muscles were analyzed (area of muscle fibers, NMJ, gene and protein expression). KOA group showed atrophy in quadriceps (15.7%) and TA (33%), with an increase in atrogin-1 and muscle RING-finger protein-1 (MuRF-1). KOA group showed quadriceps NMJ remodeling (reduction area and perimeter) and decrease in NMJ diameter in TA muscle. The expression of nicotinic acetylcholine receptor (nAChR) γ-nAChR increased and that of α-nAChR and muscle specific tyrosine kinase (MuSK) declined in the quadriceps, with a decrease in ε-nAChR in TA. MuRF-1 protein expression increased in quadriceps and TA, with no changes in neural cell adhesion molecule (NCAM). In conclusion, ACLT-induced KOA promotes NMJ remodeling and atrophy in quadriceps and TA muscles, associated with inflammatory signs and changes in muscle gene and protein expression.
Bicontinuous Interfacially Jammed Emulsion Gels (bijels) as Media for Enabling Enzymatic Reactive Separation of a Highly Water Insoluble Substrate
Authors: Cha Sanghak , Lim Hyun Gyu , Haase Martin F. , Stebe Kathleen J. , Jung Gyoo Yeol , Lee Daeyeon 
Published: April 2019

AbstractAlthough enzymes are efficient catalysts capable of converting various substrates into desired products with high specificity under mild conditions, their effectiveness as catalysts is substantially reduced when substrates are poorly water-soluble. In this study, to expedite the enzymatic conversion of a hydrophobic substrate, we use a bicontinuous interfacially jammed emulsion gel (bijel) which provides large interfacial area between two immiscible liquids: oil and water. Using lipase-catalyzed hydrolysis of tributyrin as a model reaction in a batch mode, we show that bijels can be used as media to enable enzymatic reaction. The bijel system gives a four-fold increase in the initial reaction rate in comparison to a stirred biphasic medium. Our results demonstrate that bijels are powerful biphasic reaction media to accelerate enzymatic reactions with various hydrophobic reagents. This work also demonstrates that bijels can potentially be used as reaction media to enable continuous reactive separations.
Effect of nitrogen on grain growth and formability of Ti-stabilized ferritic stainless steels
Authors: Lee Mun Hyung , Kim Rosa , Park Joo Hyun 
Published: April 2019

AbstractThe relationship between the grain size of as-cast and cold rolled 16%Cr ferritic stainless steel and the surface roughness defect, called ridging during forming was investigated. The ridging height corresponded to the grain size of the as-cast sample. The nitrogen content of 140 ppm yielded the minimum grain size and the minimum ridging height observed, whereas the nitrogen content of 50 ppm yielded the maximum grain size and the maximum ridging height observed. Ridging results from different plastic anisotropies of band structure composed of colonies. Through the EBSD analysis, the texture of mixed colonies composed of ND//{112} and ND//{331} in the 50 ppm nitrogen steel underwent more severe ridging than the randomly texture in the 140 ppm nitrogen steel sample. Therefore, an effective means to reduce the ridging of ferritic stainless steel during the forming process is to form a random texture by enhancing the formation of fine equiaxed grain during the casting process. During equal holding times at 1200 °C, the 80 ppm nitrogen sample was definitely coarsened, whereas the 200 ppm nitrogen sample underwent slower grain growth. Zener pinning force, which is proportional to the number of TiN particles on grain boundaries, was relatively strong in samples of 200 ppm nitrogen content, corresponding to slower grain growth. Although the Zener pinning force great affected with increasing nitrogen content, there may not affect the trend of initial cast grain size to be changed as much during annealing.
Cancer and cancer survival modulates brain and behavior in a time-of-day-dependent manner in mice
Authors: Santos Jessica C. , Bever Savannah R. , Sullivan Kyle A. , Pyter Leah M. 
Published: April 2019

AbstractImprovements in breast cancer therapy/diagnosis have substantially increased the cancer survivor population, although many survivors report persistent mental health issues including fatigue, mood and anxiety disorders, and cognitive impairments. These behavioral symptoms impair quality-of-life and are often associated with increased inflammation. Nocturnal rodent models of cancer are critical to the identification of the neurobiological mechanisms underlying these behavioral changes. Although both behavior and immunity display distinct diurnal patterns, most rodent research in this field is performed during the rodents’ inactive (light) period, which could potentially undermine the conclusions and clinical relevance. Therefore, here we tested the extent to which mammary tumors or tumor resection (“survivors”) in mice affects behavior and neuroinflammation in a nyctohemeral (day versus night)-dependent manner. Indeed, only the dark (active) phase unmasked fatigue-like behavior and altered novel object investigation for both tumor-bearing and -resected mice relative to surgical controls. Several inflammatory markers were expressed in a time-of-day-dependent manner (lower in the dark phase) in the blood and brains of surgical control mice, whereas this temporal pattern was absent (IL-1β, CXCL1, Myd88, Cd4) or reversed (C3) in the respective tissues of tumor-bearing and -resected mice. Taken together, these data indicate that the time of day of assessment significantly modulates various persistent and transient tumor-induced behavioral and immune changes.
Preparation and characterization of general-purpose gelatin-based co-loading flavonoids nano-core structure
Authors: Song Xiaoqing , Gan Kang , Qin Shuang , Chen Liang , Liu Xiuju , Chen Tianjie , Liu Hong 
Published: April 2019

AbstractFlavonoids (FLAs) possess anti-cancer, anti-viral, anti-bacterial, and anti-oxidant properties. In this study, gelatin nanoparticles (GNPs) with controllable surface potential and diameter was prepared through a modified two-step desolvation. Two well-known flavonoids, namely, low-molecular weight Genistein (GEN) and high-molecular weight Icariin (ICA), were adsorbed onto the surface of GNPs (FLA@GNPs). The characteristics of GNPs and the main parameters affecting flavonoid adsorption were studied to evaluate the adsorption capacity and structural stability of FLA@GNPs. Furthermore, co-adsorption of GEN and ICA was detected. The adsorption mechanism of GNPs with FLA was further discussed. Results showed that the low-molecular weight GEN could be effectively adsorbed by GNPs, and their entrapment efficiencies were over 90% under optimized conditions. The total drug loading of the co-adsorbed FLA@GNPs was significantly higher than that of the single drug loaded (GEN or ICA). GEN@GNPs could maintain its structural stability under acidic conditions (pH = 2) at room temperature (25 °C). This protective function enables both ICA and GEN to be bioactive at room temperature for at least 180 days. The characteristics of GNPs adsorption indicate that the hydrogen bonding theory of the combination of gelatin molecules with polyphenols cannot sufficiently explain the binding of GNPs with polyphenols. FLA@GNPs is a promising general-purpose gelatin-based co-loading preload structure with simplified operation and storage condition.
Slip on a mapped normal fault for the 28th December 1908 Messina earthquake (Mw 7.1) in Italy
Authors: Meschis M. , Roberts G. P. , Mildon Z. K. , Robertson J. , Michetti A. M. , Faure Walker J. P. 
Published: April 2019

AbstractThe 28th December 1908 Messina earthquake (Mw 7.1), Italy, caused >80,000 deaths and transformed earthquake science by triggering the study of earthquake environmental effects worldwide, yet its source is still a matter of debate. To constrain the geometry and kinematics of the earthquake we use elastic half-space modelling on non-planar faults, constrained by the geology and geomorphology of the Messina Strait, to replicate levelling data from 1907–1909. The novelty of our approach is that we (a) recognise the similarity between the pattern of vertical motions and that of other normal faulting earthquakes, and (b) for the first time model the levelling data using the location and geometry of a well-known offshore capable fault. Our results indicate slip on the capable fault with a dip to the east of 70° and 5 m dip-slip at depth, with slip propagating to the surface on the sea bed. Our work emphasises that geological and geomorphological observations supporting maps of capable non-planar faults should not be ignored when attempting to identify the sources of major earthquakes.
The changing relationship between ENSO and its extratropical response patterns
Authors: Soulard Nicholas , Lin Hai , Yu Bin 
Published: April 2019

AbstractEl Niño-Southern Oscillation (ENSO) can influence Northern Hemisphere seasonal conditions through its interaction with the Pacific-North American pattern (PNA) and the Tropical Northern Hemisphere pattern (TNH). Possibly due to Earth’s changing climate, the variability of ENSO, as well as the zonal location of its sea-surface temperature (SST) anomaly, is changing. Along with this, the strength and location of the jet, in which these atmospheric patterns are embedded, are changing. Using a simple tracking algorithm we create a continuous time series for the zonal location of ENSO’s SST anomaly, and show that the relationship between ENSO and the PNA is linearly sensitive to this location, while its relationship with the TNH is not. ENSO’s relationship with both the TNH and PNA is shown to be strongly influenced by the position of the Pacific jet stream. The ENSO-TNH relationship is found to be linked to phase changes of the Atlantic Multidecadal Oscillation, and the resulting changes in SST and jet speed.
Tropomyosin concentration but not formin nucleators mDia1 and mDia3 determines the level of tropomyosin incorporation into actin filaments
Authors: Meiring Joyce C. M. , Bryce Nicole S. , Niño Jorge Luis Galeano , Gabriel Antje , Tay Szun S. , Hardeman Edna C. , Biro Maté , Gunning Peter W. 
Published: April 2019

AbstractThe majority of actin filaments in human cells exist as a co-polymer with tropomyosin, which determines the functionality of actin filaments in an isoform dependent manner. Tropomyosin isoforms are sorted to different actin filament populations and in yeast this process is determined by formins, however it remains unclear what process determines tropomyosin isoform sorting in mammalian cells. We have tested the roles of two major formin nucleators, mDia1 and mDia3, in the recruitment of specific tropomyosin isoforms in mammals. Despite observing poorer cell-cell attachments in mDia1 and mDia3 KD cells and an actin bundle organisation defect with mDia1 knock down; depletion of mDia1 and mDia3 individually and concurrently did not result in any significant impact on tropomyosin recruitment to actin filaments, as observed via immunofluorescence and measured via biochemical assays. Conversely, in the presence of excess Tpm3.1, the absolute amount of Tpm3.1-containing actin filaments is not fixed by actin filament nucleators but rather depends on the cell concentration of Tpm3.1. We conclude that mDia1 and mDia3 are not essential for tropomyosin recruitment and that tropomyosin incorporation into actin filaments is concentration dependent.