bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of periconceptional folic acid supplementation on the risk of neural tube defects associated with a previous spontaneous abortion or maternal first-trimester fever
Authors: Pei Lijun , Wu Jilei , Li Jiajia , Mi Xin , Zhang Xiaofen , Li Zhengyu , Zhang Yuan 
Published: June 2019

AbstractSTUDY QUESTIONDoes maternal periconceptional no folic acid supplementation have an increased risk of neural tube defects (NTDs) associated with previous spontaneous abortion or first-trimester fever?SUMMARY ANSWERMaternal periconceptional no folic acid supplementation can increase the risk of NTDs associated with previous spontaneous abortion or first-trimester fever, independent of known confounding factors.WHAT IS KNOWN ALREADYMaternal periconceptional folic acid deficiency can increase the risk of NTDs. However, whether an interaction between periconceptional no folic acid supplementation and history of spontaneous abortion or first-trimester fever may have an increased risk of NTDs remains unknown.STUDY DESIGN, SIZE, DURATIONA population-based case–control study was performed including 104 nuclear families with offspring with NTDs and 100 control families with normal offspring between 1993 and 2002.PARTICIPANTS/MATERIALS, SETTING, METHODSWe investigated the potential interaction between periconceptional no folic acid use and a maternal history of spontaneous abortion or first-trimester fever in the risk for NTDs. Information on exposure factors was obtained at the onset of pregnancy, and pregnancy outcomes were collected during the first week after delivery or at the time of termination of the pregnancy. A multivariate logistic regression analysis was performed.MAIN RESULTS AND THE ROLE OF CHANCEThe interaction between periconceptional no folic acid use and a maternal history of spontaneous abortion markedly increased the risk of NTDs (adjusted odds ratio (aOR) 18.68, 95% CI, 4.43–78.76) after adjusting for potential confounding factors. The interaction coefficient was found to be 2.08, higher than 1, indicating that there is a significant interaction between two factors. Mothers who did not take periconceptional folic acid and had first-trimester fever had an increased risk of NTDs (aOR 21.81, 95% CI, 8.81–80.73). However, the interaction coefficient was found to be 0.62, less than 1, indicating that there is no significant interaction between two factors.LIMITATIONS, REASONS FOR CAUTIONA potential limitation was that the interval between the previous spontaneous abortion and the beginning of the subsequent pregnancy could not be estimated accurately, but was at least 1 year or more.WIDER IMPLICATIONS OF THE FINDINGSWe emphasize that a previous spontaneous abortion may represent a first occurrence of NTDs rather than be the cause of NTDs. Our findings indicate that mothers with a history of spontaneous abortion are ideal candidates for periconceptional folic acid supplementation.STUDY FUNDING/COMPETING INTEREST(S)This work was supported by National Natural Science Foundation of China (41871360) and Danone Nutrition Center for Dietary Nutrition Research and Education Foundation (DIC2015-05). There are no competing interests to declare.
Universal standards for the concept of trust in online dispute resolution systems in e-commerce disputes
Authors: Abedi Fahimeh , Zeleznikow John , Bellucci Emilia 
Published: June 2019

Abstract
The need for an appropriate jurisdiction for electronic commerce disputes has led to the well-established mechanism for solving disputes through the internet known as the Online Dispute Resolution (ODR). Currently, there is no universal agreement about the concept of trust in ODR systems, although this issue has been widely discussed in the field of Alternative Dispute Resolution (ADR). The current study aimed to develop a set of standards to enhance trust and confidence in using ODR systems. In this study, we have adopted a new approach in the ODR field, and no similar research has been conducted. This study used a quantitative (online survey) and mainly qualitative approach (interview) for gathering data. After analysing data, this research identified three elements as standards to measure trust in ODR systems including knowledge, expectations of fairness and code of ethics. Finally, our findings provide several practical and methodological implications.
Smartphone photography as a possible method of post-validation trachoma surveillance in resource-limited settings
Authors: Snyder Blake M , Sié Ali , Tapsoba Charlemagne , Dah Clarisse , Ouermi Lucienne , Zakane S Alphonse , Keenan Jeremy D , Oldenburg Catherine E 
Published: June 2019

Abstract

Background
Validation of trachoma elimination requires monitoring after discontinuation of trachoma program activities, though such evaluations are not commonly done.

Methods
Conjunctival examinations and smartphone photography were performed on a random sample of pre-school children from 15 villages in a region of Burkina Faso thought to have eliminated trachoma.

Results
No clinically active trachoma was detected by in-field or photographic evaluation. Smartphone images demonstrated high agreement with field grading (&gt;99% concordance).

Conclusions
Trachoma appears to have been eliminated from this area of Burkina Faso. Smartphone cameras may be a useful aid for monitoring in resource-limited settings.
Diffusion, implementation, and use of Research Electronic Data Capture (REDCap) in the Veterans Health Administration (VA)
Authors: Paris Bonnie L , Hynes Denise M 
Published: June 2019

AbstractThis case study describes the implementation of the Research Electronic Data Capture (REDCap) software at the United States Department of Veterans Affairs Veterans Health Administration (VA). VA REDCap enables secure and standardized data collection, fosters collaboration with external researchers through use of a widely used data management tool, facilitates multisite studies through use of data forms that can be shared across sites within and outside the VA, is well suited to health services research studies and quality improvement projects, and enables exporting data for analysis in the VA secure computing environment. Using a diffusion of innovation framework approach, authors explore organizational factors that shaped adoption of REDCap technology and constraints on its use within the VA. Lessons learned from the VA experience are discussed.
MiR-21 Regulates Keloid Formation by Downregulating Smad7 via the TGF-β/Smad Signaling Pathway
Authors: Wu Junliang , Fang Lu , Cen Ying , Qing Yong , Chen Junjie , Li Zhengyong 
Published: June 2019

Abstract
A keloid is a benign fibroproliferative skin tumor that results from abnormal wound healing after injury and tends to grow beyond the boundary of the original wound; the mechanism of keloid formation is still unclear. MicroRNA-21 (MiR-21) is a representative microRNA that plays a key role in a variety of fibrotic diseases via the transforming growth factor-β/Smad signaling pathway. The aim of our study was to explore the mechanism of keloid formation. First, we found that the expression of miR-21 in keloids and keloid fibroblasts was significantly upregulated by microRNA microarray and real-time polymerase chain reaction. Additionally, at the protein level, our study confirmed that the overexpression of miR-21 could promote the process of keloid fibrosis to some extent and also indicated that a low expression of miR-21 could inhibit the process of keloid fibrosis. Finally, the results proved that miR-21 could participate in the keloid fibrosis process through negative regulation of its downstream target gene Smad7 via the transforming growth factor-β/Smad signaling pathway, which provides a guiding framework for further studies and new theoretical support for keloid clinical treatment.
Influence of Menstrual Cycle Timing on Screening Breast MRI Background Parenchymal Enhancement and Diagnostic Performance in Premenopausal Women
Authors: Dontchos Brian N , Rahbar Habib , Partridge Savannah C , Lehman Constance D , DeMartini Wendy B 
Published: June 2019

Abstract

Purpose
To assess the influence of menstrual cycle timing on background parenchymal enhancement (BPE) and performance on screening breast magnetic resonance imaging (MRI) in premenopausal women at high risk for developing breast cancer.

Methods
After Institutional Review Board approval, all screening breast MRIs performed from January 2007 through November 2010 in premenopausal women in whom day from last menstrual period was recorded were identified. Prospectively recorded BPE levels and Breast Imaging Reporting and Data System MRI assessments were extracted from our database. Subject outcomes were determined by using biopsy, imaging follow-up, and linkage with the regional tumor registry (minimum 12-month follow-up). Associations of BPE levels (minimal/mild versus moderate/marked) with menstrual cycle phase (follicular [day 0–15] versus luteal [day 16–35]) and week (1, 2, 3, or 4) were compared. Differences in MRI performance metrics, including abnormal interpretation rate (AIR), positive biopsy rate (PBR), cancer yield, sensitivity, and specificity, were compared between menstrual cycle phase and menstrual cycle week.

Results
Three-hundred twenty examinations in 244 premenopausal women met inclusion criteria with nine cancers diagnosed. BPE levels were not associated with menstrual cycle phase or week (P &gt; 0.05). MRI performance metrics (ie, AIR, PBR, cancer yield, sensitivity, or specificity) did not differ significantly based on menstrual cycle phase or menstrual cycle week (P &gt; 0.05).

Conclusions
Obtaining screening breast MRI exams during specific phases or weeks of the menstrual cycle in premenopausal women does not reliably produce MRI examinations with lower BPE levels or improved performance.
Coffee, green tea and liver cancer risk: an evaluation based on a systematic review of epidemiologic evidence among the Japanese population
Authors: Tanaka Keitaro , Tamakoshi Akiko , Sugawara Yumi , Mizoue Tetsuya , Inoue Manami , Sawada Norie , Matsuo Keitaro , Ito Hidemi , Naito Mariko , Nagata Chisato , Kitamura Yuri , Sadakane Atsuko , Tsugane Shoichiro , Shimazu Taichi ,   for the Research Group for the Development and Evaluation of Cancer Prevention Strategies in Japan
Published: June 2019

AbstractBackgroundCoffee and green tea, two popular drinks in the Japanese, have recently drawn much attention as potential protective factors against the occurrence of liver cancer.MethodsWe systematically reviewed epidemiologic studies on coffee, green tea and liver cancer among Japanese populations. Original data were obtained by searching the MEDLINE (PubMed) and Ichushi databases, complemented with manual searches. The evaluation was performed in terms of the magnitude of association in each study and the strength of evidence (‘convincing’, ‘probable’, ‘possible’, or ‘insufficient’), together with biological plausibility.ResultsWe identified four cohort and four case-control studies on coffee and liver cancer and six cohort and one case-control studies on green tea and liver cancer. All cohort and case-control studies on coffee reported a weak to strong inverse association, with a summary relative risk (RR) for one cup increase being 0.72 (95% confidence interval [CI] 0.66–0.79). Conversely, all studies but two cohort studies on green tea reported no association, with a corresponding summary RR of 0.99 (95% CI 0.97–1.01, P = 0.37).ConclusionCoffee drinking ‘probably’ decreases the risk of primary liver cancer among the Japanese population whereas the evidence on an association between green tea and liver cancer is ‘insufficient’ in this population.
The compliance dilemma: economic sanctions and the AIPN Model Form International Joint Operating Agreement
Authors: Derman Andrew B , Melsheimer Andrew , Auner Thomas J , Sikes Skyler K 
Published: June 2019

Abstract
The current AIPN Model Form International JOA (the ‘Model Form’) does not sufficiently address circumstances and issues arising from economic sanctions, and the global contemporary trend demonstrates a significant increase in the use of sanctions by both multi-national governing bodies and nation-states. The USA implements unilateral economic sanctions more than any other country, and because US sanctions are often designed to prevent petroleum-related business with targeted countries and parties. Accordingly, this article (i) analyzes the impact US economic sanctions may have on the ability of international JOA members to both comply with sanctions and protect their interests under the JOA, and (ii) proposes certain definitions and a number of additional provisions the Model Form can adopt to address the issues arising from economic sanctions and protect the each party's interests.
Music as Feminine Capital in Napoleonic France: Nancy Macdonald’s Musical Upbringing
Authors: Geoffroy-Schwinden Rebecca Dowd 
Published: June 2019

Abstract
This microhistory situates the musical activities of Nancy Macdonald, a French student at Madame Campan’s National Institute for Young Women and Napoleon Bonaparte’s school for daughters of Legion of Honour Recipients, in broader discourses about women and music in Napoleonic France. Drawing on Pierre Bourdieu’s theories of capital, it eschews a simplistic assessment of music as either constraining or liberating young women, by arguing instead that performance operated as a kind of ‘feminine capital’, accrued and then circulated to achieve tangible socio-economic ends. A feminine-capital framework exposes the paradoxes inherent in female music-making and reveals how values about music were enculturated from girlhood to womanhood in France. This approach contributes to recent scholarship that challenges the rigid binaries previously defining women’s musical labour during the Classical era and inserts France into historiographies of women’s musical practices in the early nineteenth century.
Identification of a ligand binding hot spot and structural motifs replicating aspects of tyrosyl-DNA phosphodiesterase I (TDP1) phosphoryl recognition by crystallographic fragment cocktail screening
Authors: Lountos George T , Zhao Xue Zhi , Kiselev Evgeny , Tropea Joseph E , Needle Danielle , Pommier Yves , Burke Terrence R , Waugh David S 
Published: June 2019

Abstract
Tyrosyl DNA-phosphodiesterase I (TDP1) repairs type IB topoisomerase (TOP1) cleavage complexes generated by TOP1 inhibitors commonly used as anticancer agents. TDP1 also removes DNA 3′ end blocking lesions generated by chain-terminating nucleosides and alkylating agents, and base oxidation both in the nuclear and mitochondrial genomes. Combination therapy with TDP1 inhibitors is proposed to synergize with topoisomerase targeting drugs to enhance selectivity against cancer cells exhibiting deficiencies in parallel DNA repair pathways. A crystallographic fragment screening campaign against the catalytic domain of TDP1 was conducted to identify new lead compounds. Crystal structures revealed two fragments that bind to the TDP1 active site and exhibit inhibitory activity against TDP1. These fragments occupy a similar position in the TDP1 active site as seen in prior crystal structures of TDP1 with bound vanadate, a transition state mimic. Using structural insights into fragment binding, several fragment derivatives have been prepared and evaluated in biochemical assays. These results demonstrate that fragment-based methods can be a highly feasible approach toward the discovery of small-molecule chemical scaffolds to target TDP1, and for the first time, we provide co-crystal structures of small molecule inhibitors bound to TDP1, which could serve for the rational development of medicinal TDP1 inhibitors.
The nucleosome acidic patch directly interacts with subunits of the Paf1 and FACT complexes and controls chromatin architecture in vivo
Authors: Cucinotta Christine E , Hildreth A Elizabeth , McShane Brendan M , Shirra Margaret K , Arndt Karen M 
Published: June 2019

Abstract
The nucleosome core regulates DNA-templated processes through the highly conserved nucleosome acidic patch. While structural and biochemical studies have shown that the acidic patch controls chromatin factor binding and activity, few studies have elucidated its functions in vivo. We employed site-specific crosslinking to identify proteins that directly bind the acidic patch in Saccharomyces cerevisiae and demonstrated crosslinking of histone H2A to Paf1 complex subunit Rtf1 and FACT subunit Spt16. Rtf1 bound to nucleosomes through its histone modification domain, supporting its role as a cofactor in H2B K123 ubiquitylation. An acidic patch mutant showed defects in nucleosome positioning and occupancy genome-wide. Our results provide new information on the chromatin engagement of two central players in transcription elongation and emphasize the importance of the nucleosome core as a hub for proteins that regulate chromatin during transcription.
Targeted DNA transposition in vitro using a dCas9-transposase fusion protein
Authors: Bhatt Shivam , Chalmers Ronald 
Published: June 2019

AbstractHomology-directed genome engineering is limited by transgene size. Although DNA transposons are more efficient with large transgenes, random integrations are potentially mutagenic. Here we present an in vitro mechanistic study that demonstrates efficient Cas9 targeting of the mariner transposon Hsmar1. Integrations were unidirectional and tightly constrained to one side of the sgRNA binding site. Further analysis of the nucleoprotein intermediates demonstrated that the transposase and Cas9 moieties can bind their respective substrates independently or in concert. Kinetic analysis of the reaction in the presence of the Cas9 target–DNA revealed a delay between first and second strand cleavage at the transposon end. This step involves a significant conformational change that may be hindered by the properties of the interdomainal linker. Otherwise, the transposase moiety behaved normally and was proficient for integration in vitro and in Escherichia coli. Specific integration into the lacZ gene in E. coli was obscured by a high background of random integrations. Nevertheless, Cas9 is an attractive candidate for transposon-targeting because it has a high affinity and long dwell-time at its target site. This will facilitate a future optogenetic strategy for the temporal control of integration, which will increase the ratio of targeted to untargeted events.
A Systematic Review and Meta-analysis of Unguided Electronic and Mobile Health Technologies for Chronic Pain—Is It Time to Start Prescribing Electronic Health Applications?
Authors: Moman Rajat N , Dvorkin Jodie , Pollard E Morgan , Wanderman Robalee , Murad M Hassan , Warner David O , Hooten W Michael 
Published: June 2019

Abstract

Objective
Electronic (eHealth) and mobile (mHealth) technologies may be a useful adjunct to clinicians treating patients with chronic pain. The primary aim of this study was to investigate the effects of eHealth and mHealth interventions that do not require clinician contact or feedback on pain-related outcomes recommended by the Initiative on Methods, Measurement, and Pain Assessment in Clinical Trials (IMMPACT) guidelines in adults with chronic pain.

Methods
We searched four databases and included English language randomized controlled trials of ambulatory adults with chronic pain from January, 1 2000, to January 31, 2018, with interventions that are independent of clinician contact or feedback. In the meta-analysis, outcomes were assessed at short- (three months or less), intermediate- (four to six months), and long-term (seven or more months) follow-up.

Results
Seventeen randomized controlled trials (N = 2,496) were included in the meta-analysis. Both eHealth and mHealth interventions had a significant effect on pain intensity at short- and intermediate-term follow-up. Similarly, a significant but small effect was observed for depression at short- and intermediate-term follow-up and self-efficacy at short-term follow-up. Finally, a significant effect was observed for pain catastrophizing at short-term follow-up.

Conclusions
eHealth and mHealth interventions had significant effects on multiple short- and intermediate-term outcome measures recommended in the IMMPACT guidelines. Given widespread availability and low cost to patients, clinicians treating patients with chronic pain could consider using eHealth and mHealth interventions as part of a multidisciplinary pain treatment strategy.
Usability of donor corneas harvested from the deceased having septicaemia or malignancy
Authors: Singh T , Arya S K , Handa U , Chander J 
Published: June 2019

Abstract

Context
There is a wide gap between supply and demand in relation to healthy corneal grafts. Specific contraindications like infection and malignancy lead to non-usage of many grafts, despite the fact that deeming graft unhealthyness for these two contraindications is debatable.

Aims
This study was conceptualized to assess if corneas donated from the deceased with septicaemia or malignancy can be deemed fit for implantation.

Settings and design
Retrospective histopathological and microbiological analysis of cadaveric donor corneas.

Methods
A total of 76 donor corneas from 38 patients rejected for corneal transplantation in view of patient having septicaemia or malignancy were analysed for pathological and microbiological workup, to look for dissemination of disease within corneal tissue. Pathology workup included gross and microscopic histopathological evaluation of tissue. Microbiology workup included Grams stain and KOH with calcofluor mount, culture in blood agar, chocolate agar, Sabourauds dextrose agar and Mc Conkeys broth.

Results
A total of 46 donor corneas of 23 septicaemia patients when evaluated showed presence of culture positive infection in 18 patients (78.2%). Histopathological examination done for 30 donor corneas from 15 cancer patients did not reveal presence of tumour cells in the specimen. Corneas of two of cancer patients having septicaemia revealed growth on cultures.

Conclusions
Corneal tissues harvested from septicaemia donors showed significantly higher incidence of corneal contamination, confirming their unsuitability for usage. However, there was no incidence of tumour transmission in corneal tissues of the patients with malignancies, suggesting that they can be considered for ophthalmic purpose.
Bariatric surgery and the incidence of rheumatoid arthritis – a Swedish Obese Subjects study
Authors: Maglio Cristina , Zhang Yuan , Peltonen Markku , Andersson-Assarsson Johanna , Svensson Per-Arne , Herder Christian , Rudin Anna , Carlsson Lena 
Published: June 2019

AbstractObjectiveThe aim of this study was to determine the effect of bariatric surgery on the incidence of RA in participants of the Swedish Obese Subjects (SOS) study.MethodsThe SOS is a longitudinal study aiming to assess the effect of bariatric surgery on mortality and obesity-related diseases. This report includes 2002 subjects with obesity who underwent bariatric surgery and 2034 matched controls; none of them had RA at baseline. Cases of incident RA were identified through the Swedish National Patient Register by searching for International Classification of Diseases codes. Both intention-to-treat analyses and per-protocol analyses are reported. In the per-protocol analysis, participants from the control group who underwent bariatric surgery later on during follow-up were censored at the time of surgery.ResultsDuring follow-up, 92 study participants developed RA. The median follow-up was 21 years (range 0–29). Bariatric surgery was neither associated with the incidence of RA in the intention-to-treat analysis [hazard ratio (HR) 0.92 (95% CI 0.59, 1.46), P = 0.74], nor in the per-protocol analysis [HR 0.86 (95% CI 0.54, 1.38), P = 0.53]. Weight change at the 2 year follow-up, expressed as the change in BMI compared with baseline, did not associate with the development of RA. Higher serum CRP levels and smoking associated with the future development of RA independent of other factors.ConclusionsWe did not detect any association between bariatric surgery and the incidence of RA in subjects affected by obesity followed up for up to 29 years.ClinicalTrials.gov(http://clinicaltrials.gov): NCT01479452.