bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hypoxia-inducible factor may induce the development of liver fibrosis in Budd–Chiari syndrome by regulating CD248/endosialin expression: A hypothesis
Authors: Tian Ye , Deng Han , Han Lei , Hu Sijun , Qi Xingshun 
Published: June 2018

Abstract
Budd-Chiari syndrome (BCS) leads to the development of liver fibrosis in most of the cases. However, the mechanism of BCS-related liver fibrosis is unclear, and it may be largely different from that induced by chronic viral hepatitis. Hepatic stellate cell (HSC) and its specific marker CD248/endosialin are known to play an important regulatory role in the development of liver fibrosis. Additionally, hypoxia microenvironment and hypoxia-inducible factor (HIF) are involved in the regulation of CD248/endosialin. Therefore, we hypothesize that hypoxia microenvironment which develops due to BCS can regulate the expression of CD248/endosialin in HSC via HIF signaling pathway, which then affects the function of HSC and development of liver fibrosis. To confirm the hypothesis, two major investigations are necessary: (1) in the BCS animal model and clinical studies, the relationship between the severity of liver fibrosis and the expression of HIF and CD248/endosialin in HSC will be explored; and (2) in the in vitro cell system, the effect of hypoxic microenvironment, HIF-1α or HIF-2α, on the expression of CD248/endosialin in HSC will be explored. It will be important to elucidate whether HIF signaling pathway regulates the expression of CD248/endosialin, thereby inducing the development of BCS-related liver fibrosis.
Impact of Customer Value, Brand Image and Product Attributes to Satisfaction and Loyalty Tourism Visitors in Jember Regency
Authors: Qomariah Nurul 
Published: June 2018

Abstract
This study aims to determine the impact of customer value, brand image and product attributes to the satisfaction and loyalty of visitors on the existing coastal tourism in Jember Regency which includes Papuma Beach, Watu Ulo Beach, Payangan Beach, Puger Beach and Paseban Beach and Bande Alit Beach. The population of this study is all visitors of coastal tourism in Jember District. Sampling method is purposive sampling with total sample as many as 300 respondents. With the number of respondents each beach tour amounted to 50 respondents. Quantitative analysis using multiple regression analysis. The result of validity test and reliability test indicate that measuring instrument can be used well. Hypothesis test shows that customer value, brand image and product attribute have an effect on visitor satisfaction. The value of the customer does not affect the loyalty of visitors, while the brand image, product attributes and visitor satisfaction affect the loyalty of visitors.
Rationale and Implications of Psychoactive Substances Use Among Commercial Road Transport Workers in Lokoja, Nigeria
Authors: David Ajibade , Toyin Adefolaju 
Published: June 2018

Abstract
This study investigates the rationale and implications of psychoactive substances use among commercial road transport workers in Lokoja, Nigeria, using cross-sectional survey research design. The study population comprises of trailer drivers, taxi drivers, tipper drivers and long distance bus drivers registered in Lokoja. However, due to variation in the population of each of the study groups, a quota of forty five (45) participants were allotted to each of the groups (totalling one hundred and eighty, 180) in order to prevent over-representation of one group over the other. Selection of respondents at garage/park level was however done using purposive sampling technique. Data were collected using semi-structured questionnaire and statistically analysed using frequencies, percentage, and weighted means. Results of the study show that majority of the respondents used psychoactive substances to overcome depression, stay awake while driving, overcome daily problems and for pleasure. These were however found to sometimes result to alteration in the moods and emotional state of the respondents, road traffic accidents, hangover and further involvement in substances usage. In view of these findings, it is recommended that Government should intensify campaign through print and electronic media as well as by organising seminar and workshop for members of commercial road transport workers not only in the study area but also in Nigeria generally, on the risks (social, psychological and health) of psychoactive substance usage.
Statistical Analysis of the Development Indicators’ Impacts on E-Commerce of Individuals in Selected European Countries
Authors: Dumičić Ksenija , Bonić Ivana Skoko , Žmuk Berislav 
Published: June 2018

Abstract
The aim of this paper is to analyse the influence of the development level indicators on the e-commerce, i.e. on the online purchase by individuals, in selected European countries in 2013. In the analysis, the main variable under study and all the independent variables are included as standardised. Based on nine variables, the principal component analysis with varimax rotation was performed and the two extracted factors were used as the regressors in the multiple regression analysis. In the regression model both components, Factor 1, which includes seven variables, called Prosperity, Investing in Education and IT Infrastructure, and Awareness, and Factor 2, comprised of two variables, called IT Skills, are statistically significant at the significance level of 1%. Both factors show a positive correlation with the online purchase of individuals. Inclusion and analysis of distributions and impacts of even nine independent variables, which make up two distinct factors affecting the e-commerce, make a new contribution of this work.
Tax Compliance at National Level
Authors: Brezeanu Petre , Dumiter Florin , Ghiur Rodica , Todor Silvia Paula 
Published: June 2018

Abstract
Throughout this study, we have shown the influence factors generating a significant impact on taxpayers’ tax behavior. We also analyzed the literature in the field, and the categories of factors that have a significant influence. Consequently, we have assigned a macroeconomic indicator in Romania, in an attempt to quantify the factors of influence. In this regard, we have built an econometric model of multifactorial regression and we have determined the impact of some elements such as: poverty, labor productivity, population confidence in state authorities, gross domestic product per capita on fiscal behavior, which was estimated through the proxy variable: tax rate. The empirical results obtained as a result of the multiple regression showed that there is a negative correlation between the fiscal behavior of the taxpayer, namely the tax compliance and the financial capacity, the labor productivity and the confidence the taxpayer has in the state authorities, while the behavior of the taxpayer the gross domestic product per capita we identify a positive correlation.
The Dynamics of Extreme Poverty in Developing Countries
Authors: Mahembe Edmore , Odhiambo Nicholas M. 
Published: June 2018

Abstract
This paper aims to analyses the trends and dynamics of extreme poverty in developing countries. The study attempts to answer one critical question: has the world achieved its number one Millennium Development Goal (MDG) target of reducing extreme poverty by half by 2015? The methodology used in this study mainly involves a descriptive data analysis during the period 1981-2015. The study used the World Bank’s US$1.90 a day line (popularly known as $1 a day line) in 2011 prices to measure the level of absolute poverty. In order to analyze the dynamics of poverty across different regions, the study grouped countries into five regions: i) sub-Saharan Africa; ii) East Asia and the Pacific; iii) South Asia; iv) Europe and Central Asia; and v) Latin America and the Caribbean. The study found that in 1990, there were around 1.9 billion people living below US$1.90 a day (constituting 36.9 percent of the world population) and this number is estimated to have reduced to around 700 million people in 2015, with an estimated global poverty rate of 9.6 percent. The world met the MDG target in 2010, which is five years ahead of schedule. However, extreme poverty is becoming increasingly concentrated in sub-Saharan Africa (SSA) and South Asia (SA), where its depth and breadth remain a challenge. SSA remains the poorest region, with more than 35 percent of its citizens living on less than US$1.90 a day. Half of the world’s extremely poor people now live in SSA, and it is the only region which has not met its MDG target.
Cluster Analysis for the Determination of Innovative and Sustainable Oriented Regions in Europe
Authors: Pelau Corina , Chinie Alexandra-Catalina 
Published: June 2018

Abstract
In the past decades the preoccupation of decision-makers towards innovation and sustainable development has gained a major importance in the policy of most countries in Europe. On one hand, efficient innovation can differentiate a country or a region from another and make a difference in the intense increasing economic, technological and social competition. On the other hand, the orientation towards sustainable development assures a clean and unpolluted, social oriented and healthy environment as a framework for the growth of a country or a region. In many cases, innovation and sustainable development go hand in hand, as innovations contribute to the development of clean technologies, while sustainable societies assure the proper environment and background for stimulating the innovation research. The objective of this research is to determine the cluster of countries in Europe which are rather oriented to innovation or to sustainable development or both and to forecast their future developments and tendencies. In order to achieve this objective, the multivariate cluster analysis was applied with the help of the SPSS program, for data provided by the Eurostat for several innovation, sustainable development and contextual indicators. In a first step, for each of the analyzed countries, the values of the indicators have been collected for the same period and the correlations among them have been determined. In the second phase the number of clusters and the cluster membership of each country was determined, by running the Ward cluster analysis. Based on the results, the characteristics of each cluster of countries was defined.
The Financial and Economic Aspects of Transport Infrastructure Development in Latvia
Authors: Kuzmina-Merlino Irina , Skorobogatova Oksana , Schmidtke Niels , Behrendt Fabian 
Published: June 2018

Abstract
This paper is devoted to topical issues in the development of transport infrastructure as a key component of the transport system of Latvia. The level of development of transport infrastructure is measured by specific economic indicators, which in their turn depend on the volume and efficiency of acquisition of sources of funding. The paper sheds light on the economic indicators of the development of the transport infrastructure in Latvia and issues of funding of this sector. The data contained in this paper reveals the size and directions of public investment in the transport infrastructure development. The paper focuses on the necessity to create the effective investment mechanism for financing the transport infrastructure of Latvia as a useful instrument in making investment decisions. Based on the theory of decision making the authors developed Investment Decision-Making Concept, which can be used when selecting investment projects in the field of transport infrastructure and their evaluation. This paper is based on the litera ture review of previously published papers of these authors. The authors refine their conceptual approach for developing an investment decision making mechanism, proposed in earlier papers, and offer recommendations aimed at policy-makers, professionals, academics and those with a broad interest in the field.
Primary Teacher Students’ Understanding of Fraction Representational Knowledge in Slovenia and Kosovo
Authors: Kolar Vida Manfreda , Hodnik Čadež Tatjana , Vula Eda 
Published: June 2018

The study of primary teacher students’ knowledge of fractions is very important because fractions present a principal and highly complex set of concepts and skills within mathematics. The present study examines primary teacher students’ knowledge of fraction representations in Slovenia and Kosovo. According to research, there are five subconstructs of fractions: the part-whole subconstruct, the measure subconstruct, the quotient subconstruct, the operator subconstruct and the ratio subconstruct. Our research focused on the part-whole and the measure subconstructs of fractions, creating nine tasks that were represented by different modes of representation: area/region, number line and sets of objects. The sample consisted of 76 primary teacher students in Slovenia and 93 primary teacher students in Kosovo. Both similarities and differences of the primary teacher students’ interpretations of the representations across the two countries were revealed and compared. The findings suggest that primary teacher students from both countries need to upgrade their understanding of fractions. The analysis confirms that the formal mathematical knowledge acquired by primary teacher students is not necessarily adequate for teaching elementary concepts in school.
Croatian Preschool Teachers’ Self-Perceived Competence in Managing the Challenging Behaviour of Children
Authors: Beaudoin Kathleen , Skočić Mihić Sanja , Lončarić Darko 
Published: June 2018

Managing behaviour is a complex component of the teaching process and one that teachers consistently identify as an area of great concern. This study aimed to examine teachers’ perceptions regarding their competence for managing the challenging behaviour of young children and to identify the factors that affect these beliefs. A total of 204 preschool teachers working in Kindergarten Rijeka, Croatia participated. Teachers completed an exploratory survey of self-perceptions of competence in managing the challenging behaviours encountered in their classrooms. Factor analysis revealed a one-factor structure for self-perceived competence, and all scales showed good psychometric properties. Preschool teachers’ assessment of their own competence in managing challenging behaviour was explained by the level of support they received from other professionals when faced with children’s challenging behaviour and prior coursework in classroom management. Participants with higher levels of professional support and more coursework in classroom management estimated themselves to be more competent in managing challenging behaviour. The resultssuggest that Croatian preschool teachers need training in classroom management and greater access to professional support personnel when working with students with challenging behaviours.
ВЛИЯНИЕ ИЗМЕНЕНИЙ НАЛОГОВОГО ЗАКОНОДАТЕЛЬСТВА РФ НА НАЛОГОВУЮ НАГРУЗКУ ОРГАНИЗАЦИЙ
Authors: Малышева Надежда Петровна , Моисеенко Светлана Леонидовна 
Published: June 2018

Налоговая нагрузка выступает одним из главных критериев инвестиционной привлекательности, поэтому предметом данной статьи является налоговая нагрузка, а целью – рассмотрение влияния изменения законодательства Российской Федерации на налоговую нагрузку. В работе рассмотрены методики определения налоговой нагрузки, предложенные такими авторами, как М.Н. Крейнина, М.И. Литвин, Е.А. Кирова и др. Особое внимание уделяется показателям и порядку расчета налоговой нагрузки, разработанному Федеральной налоговой службой России. В статье подробно рассмотрены изменения налогового законодательства в 2018 г. по отдельным налогам, выявлено влияние этих изменений на налоговую нагрузку. Авторами доказано, что по налогу на прибыль, налогу на добавленную стоимость и страховым взносам вектор реформирования смещается в сторону усиления налоговой нагрузки. Изменение общей налоговой нагрузки происходит не путем изменения ставок налоговых платежей, а путем изменения норм бухгалтерского учета или введением новых обязательных платежей, являющихся по своей сути налогами или сборами. Авторы статьи предлагают для каждого этапа развития организации или консолидированной группы определять перечень факторов и финансовых показателей, позволяющих давать качественную оценку текущей деятельности компании, например: занимаемая доля рынка; объем реализации; значения операционной и чистой прибыли; доли инвестиционных вложений и дивидендных выплат от суммы чистой прибыли. В этом случае отношение общей суммы налоговых платежей к целевому показателю каждого этапа жизненного цикла может стать дополнительным критерием эффективности. Методика определения уровня фискальной нагрузки должна учитывать особенности процесса налогообложения, она также должна давать возможность сравнить тяжесть налогового бремени для предприятий, действующих в условиях одной налоговой системы, а также использующих разные налоговые режимы. Это позволит выстроить в организации оптимальную систему налогового планирования, а также определить факторы для оценки рисков, учесть все изменения законодательства.
Spatio-temporal patterns of highly pathogenic avian influenza virus subtype H5N8 spread, France, 2016 to 2017
Authors: Guinat Claire , Nicolas Gaëlle , Vergne Timothée , Bronner Anne , Durand Benoit , Courcoul Aurélie , Gilbert Marius , Guérin Jean-Luc , Paul Mathilde C. 
Published: June 2018

Introduction
France is one of Europe’s foremost poultry producers and the world’s fifth largest producer of poultry meat. In November 2016, highly pathogenic avian influenza (HPAI) virus subtype H5N8 emerged in poultry in the country. As of 23 March 2017, a total of 484 confirmed outbreaks were reported, with consequences on animal health and socio-economic impacts for producers. Methods: We examined the spatio-temporal distribution of outbreaks that occurred in France between November 2016 and March 2017, using the space–time K-function and space–time permutation model of the scan statistic test. Results: Most outbreaks affected duck flocks in south-west France. A significant space–time interaction of outbreaks was present at the beginning of the epidemic within a window of 8 km and 13 days. This interaction disappeared towards the epidemic end. Five spatio-temporal outbreak clusters were identified in the main poultry producing areas, moving sequentially from east to west. The average spread rate of the epidemic front wave was estimated to be 5.5 km/week. It increased from February 2017 and was negatively associated with the duck holding density. Conclusion: HPAI-H5N8 infections varied over time and space in France. Intense transmission events occurred at the early stages of the epidemic, followed by long-range jumps in the disease spread towards its end. Findings support strict control strategies in poultry production as well as the maintenance of high biosecurity standards for poultry holdings. Factors and mechanisms driving HPAI spread need to be further investigated.
Accounting Outsourcing in Ukraine: Use, Problems and Prospects
Authors: Kutuzov Mikhail , Kotsiuba Yana 
Published: June 2018

This article explores the concept of outsourcing, the company’s reason to use outsourcing as a form of accounting and reporting. It was determined that nowadays outsourcing is the promising tool for cost optimization of the company.
It was determined that the outsourcing service in the Ukrainian market is quite promising. In the article, the basic advantages of accounting outsourcing were defined such as savings on accounting staff salaries; cost savings on: Organization of working places in accounting, department software, training your staff; access to skilled counseling; improvement of the quality and reliability of the functions performed by the outsourcer. The disadvantages of this service wereconsidered. The particular attention should be paid to the factors that prevent the use of accounting outsourcing in Ukraine.
Переваги діяльності та оцінка інвестування активів вітчизняних недержавних пенсійних фондів
Authors: Tesliuk Sofiya 
Published: June 2018

У статті проаналізувано переваги діяльності недержавних пенсійних фондів на вітчизняному інвестиційному ринку. Досліджено типи недержавних пенсійних фондів та особливості діяльності кожного з них.Проведено порівняльний аналіз приросту активів відкритих, корпоративних і професійних недержавних пенсійних фондів за останні роки.Досліджено джерела формування активів НПФ та можливі напрями їх використання. Наведено законодавчо закріплені напрями й обмеження інвестування активів недержавних пенсійних фондів.Досліджено проблеми ефективності інвестування активів недержавних пенсійних фондів, наведено рекомендації щодо повнішого розкриття їх інвестиційного потенціалу
Peningkatan pemahaman Gaya Belajar Siswa dengan Penerapan Inventori Gaya Belajar Remaja menggunakan Aplikasi Google Form dan Pemanfaatan Media Sosial
Authors: Mashurwati Yuyun 
Published: June 2018

Guru sebagai pendidik dewasa ini terindikasi tidak mengambil pentik aspek sensori dari siswa. Penelitian ini bertujuan untuk mengindentifikasi kondisi gaya belajar siswa. Penelitian ini merupakan penelitian deskriptifÂ yang sumber data diambil dari bagian dari classroom action Research yang sebelumnya dilaksanakan dengan meilbatkan 36 orang siswa. Intrumen penelitian ini menggunakan Inventori Gaya Belajar Remaja memanfaatkan aplikasi google form dan disebarkan dengan memanfaatkan media social serta menggunakan self evaluasi untuk mengukur efektitas dan efisiensinya. Hasil penelitian menunjukkan bahwa 71.32% siswa memiliki gaya belajar Visual, 63.85% gaya belajar Auditorial, dan 61.36% gaya belajar Kinestetik. Aplikasi Google form dan social media efektif dan efisien dalam membantu mengadministrasikan inventori gaya belajar. Guru dan Guru Bimbingan dan konseling diharapkan dapat memanfaatkan data ini dan melakukan proses pembelajaran sesuai dengan gaya belajar siswa untuk keperluan optimalisasi pelayanan dan peningkatan hasil belajar siswa.
Peluang dan Tantangan Pelayanan Konseling Pada Setting Masyarakat di Indonesia (Perspektif Dari Perkembangan Konseling Setting Masyarakat Di Amerika)
Authors: Diniaty Amirah 
Published: June 2018

Keberadaan pelayanan konseling pada setting masyarakat Indonesia yang majemuk baik dari segi latar belakang ekonomi, sosial, budaya, agama,Â pendidikan, pekerjaan dan kondisi alam disekitarnya, saat ini perlu ditinjau peluang dan tantangannya. Belajar dari apa yang telah terjadi di Amerika yang saat ini profesi konseling telah mendapat tempat di hati masyarakatnya, maka profesi konselor di Indonesia harus membenahi diri siap dengan peluang dan tantangan yang ada. Konselor yang memilih bekerja dilingkungan ini berkesempatan untuk melayani orang yang memiliki kekurangan, pecandu, orang tua, orang yang terganggu mentalnya, pegawai pemerintah dan militer, pegawai di perusahaan besar. Tugas dan tantangannya banyak. Untuk itu konselor yang bekerja pada setting masyarakat harus bersifat fleksibel, berpengetahuan luas, memiliki koneksi, dan siap untuk menanggapi beberapa permintaan.
Hubungan Self-Esteem dengan Motivasi Belajar Remaja Panti Asuhan â€˜Aisyiyah Daerah Cabang Lubuk Bagalung Padang
Authors: Olva Hermivia , Ibrahim Yulidar , Marjohan Marjohan 
Published: June 2018

The teenager who have more motivation in studying will do many activities that be useful in learning process. If they are able to think and make sure about their will have more motivation to study, have a good socialization and can manage their passion. The purpose of the research is analyzing about correlation between self-esteem with motivation in studying ofÂ teenage orphanage â€˜Aisyiyah Lubuk Bagalung Padang. Kind of research is quantitative by using correlation descriptive. The subjects of the research are 30 students. The instruments are inventory and questionnaires. The result of the research shows that there are correlation between self-esteem and motivation in studying significantly by lowing correlation.