bluuebunny/crossref_metadata_2025_split huggingface dataset:
SPACE: A Novel Digital Tool for Assessing Hippocampal Structural Integrity in Older Adults
Authors: Minta* Karolina , Colombo* Giorgio , Tee* Mervin , Low Marcus , Grübel Jascha , Wiener Jan , Chen Christopher P. , Hilal Saima , Schinazi Victor R. 
Published: November 2024

Abstract

Hippocampal atrophy is a hallmark of Alzheimer’s disease and is associated with deficits in navigation. We investigated whether a novel digital assessment, the Spatial Performance Assessment for Cognitive Evaluation (SPACE), can predict hippocampal integrity beyond traditional neuropsychological tests in older adults. Forty older male participants underwent structural MRI and completed the spatial and navigation tasks in SPACE along with a battery of neuropsychological tests typically used to detect cognitive impairment. A regression model revealed that worse performance in the path integration and mapping tasks significantly predicted smaller hippocampal volume above age, education and all neuropsychological tests. Critically, participants who successfully learned the positions of landmarks in a virtual environment during a path integration task and accurately reproduced the configuration in a mapping task had larger hippocampal volumes. These findings indicate that SPACE can serve as a valuable addition to traditional cognitive assessments by providing greater sensitivity for assessing hippocampal volume.

*Karolina Minta, Giorgio Colombo, and Mervin Tee contributed equally.
Genomic Sequencing of the Bacteria involved in the Fermentation of Ogiri and Okpehe
Authors: Ogbu Joy Chinyere , Ugoh S.C. , Etuk-Udo Godwin , Odusanya O.O. , R.A. Jimba , Prince Ogbu Chukwuemeka 
Published: November 2024

Abstract

This research focuses on the genomic sequencing of the bacteria involved in the fermentation of Okpehe and Ogiri. Isolation of the bacteria was done on the fermented samples by innoculating the samples on Nutrient Agar and MacConkey Agar and Biochemical tests (Gram staining, citrate, Oxidase and Catalase) was carried out on the organisms obtained. DNA extraction, Polymerase Chain Reaction, Gel electrophoresis and Genomic sequencing was done on the bacteria.
A Novel Software Reliability Growth Model Based on Stochastic Differential Equations for Open-Source Software
Authors: Hameed Fatimah Saad , Asker Hussein K. 
Published: November 2024

Abstract

In this study, we discussed the reliability assessment for Open Source Software by introducing a new software reliability growth model based on stochastic differential equations. We considered that the software failure rate depends on time (t), and the reporting of faults is irregular. First, we determined its probability distribution by transforming the fundamental differential equation describing fault detection into a stochastic differential equation of Itˆo type. Second, we calculated several software reliability measures, such as the expected number of faults and the mean time between cumulative and instantaneous software failures. Using data from actual software testing procedures, we used the maximum likelihood method to estimate the model’s unknown parameters. Finally, we compared the new model with two other reliability growth models (the exponential and the delayed S-shaped), using a set of software quality standards to identify the best model. The results demonstrated that the proposed model can enhance the quality of OSS systems.
ESG Integration in Corporate Governance: A Comparative Study of Practices in Emerging Markets
Authors: Kouam Arthur William Fodouop 
Published: November 2024

Abstract

This study investigates integrating environmental, social, and governance (ESG) factors into corporate governance practices among companies in emerging markets. Despite the growing global importance of ESG considerations, significant gaps remain in understanding how these practices are adopted within the unique contexts of these economies. The study uses a quantitative research paradigm to analyze data from a sample of 250 companies across diverse sectors, including finance, manufacturing, energy, and technology. To establish a robust empirical foundation, data is sourced from reliable secondary materials, specifically corporate disclosures, industry reports, and financial databases. Employing Ordinary Least Squares (OLS) regression analysis, the study explores the impacts of governance practices, drivers, and barriers on ESG integration, effectively capturing the complexities of these interactions. The research identifies several effective ESG integration practices, including structured policies, comprehensive stakeholder engagement, and transparent reporting mechanisms. Critical drivers for integration include solid regulatory support, active stakeholder influence, and rising market demand for sustainability. Conversely, significant barriers to effective ESG integration include weak regulatory frameworks, cultural resistance, and a lack of high-quality ESG data. Notably, regional disparities emerged, with Asian firms exhibiting superior ESG integration compared to those in Eastern Europe, underscoring the importance of localized economic and regulatory conditions. This research contributes to the literature by comprehensively analyzing ESG integration practices in emerging markets. It emphasizes the need for tailored strategies that account for contextual factors, thus offering valuable insights for corporate leaders navigating sustainability in dynamic environments.
Absorption Loss Modeling Tools for Terahertz Band Drone Communications
Authors: Sekeroglu Berkay , Erdem Mikail , Gurbuz Ozgur , Saeed Akhtar , Sendag Hayrettin Cagan , Kulaksizoglu Murat 
Published: November 2024

Abstract

This paper compares four terahertz (THz) band absorption loss modeling tools: International Telecommunication Union (ITU)-R P.676 model, Line-by-Line Radiative Transfer Model (LBLRTM), Atmospheric Model (am), and HITRAN on the Web (HotW). We evaluate the THz band drone communication tools under horizontal and vertical communication scenarios. We use the U.S. Standard 1976 and tropical weather profiles to generate path loss data across different altitudes, frequencies, and distances. We also employ a simple analytical model, fitting the data from the ITU, LBLRTM, and am tools to assess its accuracy in predicting path loss. Our results demonstrate high consistency among the tools, with path loss differences becoming more significant in vertical scenarios. This study provides the first comprehensive comparison of four widely used absorption loss modeling tools for THz band drone communications, considering various scenarios and weather conditions.
УМ И УМОПОСТИГАЕМОЕ КАК ПРЕДМЕТ НАУКИ О ДУШЕ У АРИСТОТЕЛЯ*
Authors: Н.П. Волкова 
Published: November 2024

В статье анализируется аристотелевская концепция активного и пассивного умов, изложенная в третьей книге трактата Аристотеля О душе. Отмечено, что вопрос о взаимодействии этих умов и связь учения об активном уме с XII книгой Метафизики признаны историками философии (Росс, Рист) одними из наиболее противоречивых в философии Аристотеля. К рассматриваемой Аристотелем в О душе проблеме двух умов обращались Теофраст и комментаторы Аристотеля (такие как Александр Афродисийский, Филопон, Симпликий и др.). Эта проблема послужила отправной точкой для самостоятельных размышлений таких философов, как Аверроэс и Фома Аквинский. Автор ставит перед собой цель не только реконструировать по трактату Аристотеля О душе его учение о разумной части души как первой энтелехии, и обнаружить те основания, которые побудили греческого мыслителя говорить об активном и пассивном уме, но и выяснить, какой ум может быть предметом изучения науки о душе как части науки о природе, а какой не может.
ПАДЕНИЕ СЕЯНА БЕНА ДЖОНСОНА И «ТАЦИТИЗМ» В АНГЛИИ КОНЦА XVI — НАЧАЛА XVII ВЕКА
Authors: О.В. Дмитриева 
Published: November 2024

В работе исследуется пьеса Бена Джонсона Падение Сеяна, в которой нашли отражение многие тенденции в развитии английской и континентальной политической мысли рубежа XVI-XVII вв. Проанализировав характер и особенности издания данного текста, автор приходит к выводу о том, что Джонсон дает в нем негативную оценку идеям макиавеллизма и теории «государственного интереса», при этом выступая апологетом сильной власти и отвергая идею активного сопротивления ей. Идеалом правителя он видит монарха, приверженного идее общественного блага, а гарантией против тирании — культивирование индивидуальных добродетелей, тяготея к синтезу стоицизма, гражданского гуманизма и христианской морали.
The article explores the tragedy Sejanus, His Fall by Ben Jonson, which presented a reflection upon various trends in English and continental political thought in the late XVIth – early XVIIth cc. the author analyzed the character and the specific way of publication of the play; she concludes that Jonson offered a negative interpretation of the Machievelism and the theory of ‘reason of state’. At the same time, he was an apologist of a strong monarch and rejected resistance theories. Jonson’s ideal was a monarch faithful to the idea of common wealth, and cultivation of personal virtues was viewed by him as a guarantee against tyranny. Thus, his text presented a synthesis of stoicism, civic humanism and Christian ethics. Keywords: Ben Jonson, tacitism, neostoicism, political culture, ‘reason of state’.
ДУХОВНОЕ И ЗЕМНОЕ ОРУЖИЕ ВОИНОВ ХРИСТОВЫХ
Authors: Е.В. Калмыкова 
Published: November 2024

Статья посвящена идее духовной войны и духовного оружия в средневековой религиозной литературе. Являясь частью человеческой жизни, войны порождали бесконечное число образов для простых и сложных метафор и аллегорий в текстах, формально никак не связанных с военной тематикой. Между тем, сама идея существования воинства Христова, некоторые члены которого все еще пребывают на земле, оказывается глубже простой метафоры. В центре внимания автора эволюция образа воина Христова от святого или мученика за веру до каждого христианина, не зависимо от сословия или пола. Включение в состав воинства Христова всех верующих принципиально изменило масштаб уготованной для них войны. Призывая избранных к оружию, авторы поздней Античности и раннего Средневековья предполагали ведение войны с Сатаной и его приспешниками, в то время как богословы и проповедники более позднего периода рассуждали об индивидуальной борьбе человека со своими пороками, грехами и искушениями.
This article examines the notion of spiritual war and spiritual weapons in medieval religious literature. As part of life, wars were a source of both simple and complex images for metaphors and allegories in texts that were formally unrelated to military affairs. At the same time, the idea of the soldiers of Christ, some of them acting in earthly life, turns out to be more than a simple metaphor. The focal point of the article is the evolution of the image of Christ’s soldier from a saint or a martyr into every Christian of any social status and gender. The inclusion of all believers into the ranks of the soldiers of Christ fundamentally changed the scale and nature of a Spiritual war they were supposed to wage. Calling the chosen to arms, late Antique and early medieval authors suggested a war against the Devil and his followers, while later theologians and preachers talked about individual struggle against vices, sins and temptations.
The importance of mass balance in life cycle assessment of nature-based solutions for wastewater treatment: key learning points from a case study
Authors: Dufossé Karine , Forquet Nicolas , Molle Pascal , Pradel Marilys , Loiseau Eléonore 
Published: November 2024

ABSTRACT
This study aims to perform a comprehensive life cycle assessment (LCA) of nature-based solutions (NBS) for wastewater treatment (WWT), specifically focusing on a French vertical flow (VF) wetland. The LCA encompasses the construction phase, operational phase, and end-of-life management, with a particular emphasis on achieving a balanced mass flow for carbon, nitrogen, and phosphorus across air, water, and soil compartments. The VF wetland is evaluated for its environmental impacts and compared to a conventional activated sludge system. The key findings reveal that the VF wetland achieves substantial reductions in resource use, yet requires significantly more land and exhibits higher impacts on greenhouse gas emissions and in categories sensitive to water emissions. The results underline the importance of complete mass balances in LCA of NBS to accurately identify environmental hotspots. Recommendations for methodological improvements and system boundary definitions are provided to enhance the definition of mass balance within NBS.
Antagonism of NativeTrichodermaspp. from the Peruvian Central Rainforest onPhytophthora capsiciand Effects on Capsicum annuum
Authors: Teves Anchivilca Percy Ivan , Felix Vasquez Yovana , Gonzales Borda Fiorella Fernanda , León Modeneci Gina Rubi , Honorio Quispe Karen Lizbeth , Llanos Melo Alejandro Kepler , Gonzales Miranda Maria del Carmen 
Published: November 2024

The genus Trichoderma is primarily recognized for its role as a biocontrol agent against various plant pathogens. Among the actions exhibited by this genus is its activity against Phytophthora capsici (P.c.), the causal agent of crown rot, foliar blight, and fruit rot in pepper cultivation. This study evaluated the antagonistic activity of T. koningiopsis and T. lentiforme against P. capsici. These species, isolated from the Peruvian central rainforest, were previously identified through morphological and molecular methods. The research was conducted in two phases: 1) In the in vitro phase, the treatments included isolates of T. koningiopsis, T. lentiforme, and T. harzianum, each tested both individually and against P. capsici, along with a positive control (+P.c.); 2) For the in vivo phase a negative control (-P.c.) was included. The in vitro antagonism evaluation featured a dual plate confrontation assay between Trichoderma spp. and P. capsici on Potato Dextrose Agar (PDA) medium, wherein the percentage of radial growth inhibition (PRGI) and growth rate were assessed. In the greenhouse, bell pepper seedlings cv ‘Piquillo’ were inoculated with 20 mL of a Trichoderma spp. conidia suspension (108 spores/mL) at transplanting, 14, and 28 days after transplanting (dat). P. capsici was inoculated at 28 dat near the base of the plant using three grains (0.27 g) of previously colonized wheat. The experiments followed a completely randomized design (CRD) with Tukey’s mean comparison test at a 0.05 significance level. The evaluated variables included plant height (cm), incidence (%), severity (%), fresh weight (g), and dry weight (g). The in vitro antagonism results showed that T. koningiopsis and T. lentiforme exhibited PRGI values of 38.08 % and 37.91 %, respectively, against P. capsici. In the greenhouse assay, the bell pepper plants co-inoculated with T. lentiforme and P. capsici exhibited higher values in plant height (21.11 cm), root length (11.02 cm), and fresh weight (1.4 g). Additionally, the degree of foliar and root severity in all treatments with Trichoderma spp. and P. capsici was lower (Grade 0 to Grade 2), unlike the treatment inoculated solely with the pathogen (Grade 3 to Grade 4). In conclusion, this study demonstrates the potential of T. koningiopsis and T. lentiforme as biocontrol agents against P. capsici in pepper crops.
Influencers e informações sobre saúde pelas redes sociais
Authors: Castro Marta Rocha de 
Published: November 2024

O artigo tem como objetivo avaliar a exploração nas redes sociais digitais sobre o tema cuidados com a saúde através de uma revisão sistêmica nas bases de dados Portal Capes e PUBMED. Os descritores usados foram Redes sociais digitais e informação em saúde; influencers e informações e saúde. Com esses descritores foram encontrados 74 resultados e foram subtraídos os artigos que não constavam no título as palavras redes sociais digitais e saúde, Instagram e saúde, influencers e saúde ou mídias sociais e saúde. Além de serem excluídos os artigos que não apresentavam resumo ou que não tinham acesso aberto e artigos que não trazem relevância para a pesquisa. Na íntegra foram selecionados 9 artigos. Através da análise dos artigos selecionados foi possível concluir que as redes sociais quando utilizadas por escolas, instituições de saúde e profissionais, com a finalidade de promover educação em saúde obteve respostas positivas, no entanto, principalmente durante e após a pandemia, muitas narrativas e relatos falsos foram postados em redes sociais, gerando impactos negativos sobre os serviços de saúde. As redes sociais têm potencial para serem ferramentas eficazes na educação em saúde, desde que se tenha um controle maior dos conteúdos postados, e que possa unir a linguagem acessível ao conhecimento científico para benefício da população.
A teoria normativa da modernidade na pespectiva habermasiana
Authors: Silva Vitor Gomes da , Silva Antonio Tancredo P. da 
Published: November 2024

Em uma sociedade a instauração de conflitos de pretensões não é aprazível para os cidadãos, sendo necessário o uso de formas e instrumentos para que ele seja eliminado. Diante deste panorama conflituoso surge o Direito como mediador social, pois funciona como uma ferramenta de participação que tem a habilidade de promover a realização da cidadania, buscando instalar e restituir pactos sociais, tornando os sujeitos conscientes de seus direitos e deveres e mais solidários perante as desordens sociais experimentados por distintos sujeitos. Para Habermas (1997), o direito está situado em um conflito entre facticidade e validade, entre o que se encontra no nível factual e o no normativo. “O que é válido precisa estar em condições de comprovar-se contra as objeções apresentadas factualmente” (Habermas, 1997, p. 56). É uma relação conflituosa posicionada internamente e externamente ao próprio direito. O interesse de Habermas está ancorado no ponto de vista metódico, com o qual a sociologia do direito não pode prescindir de uma reconstrução das condições de validade do acordo de legalidade, pressuposto nos modernos sistemas de direito. Para Habermas, a positivação do direito moderno e a diferenciação entre direito e moral não faz desaparecer a pretensão de legitimação do direito, ao passo que mesmo a positividade jurídica pós-metafísica necessita de princípios justificados racionalmente e, dessa maneira, universais. Na teoria social de Max Weber verificou a concretização do direito como um modo de moralização do ordenamento jurídico, com a caracterização da estrutura formal do direito e a sua indispensabilidade. Esse procedimento é chamado de juridificação, pois conjectura o aumento da normatização jurídica sobre a vida social. Em Kant, sua forma do “imperativo categórico” é instrumentada com características discursivas e consistirão no representante para do processo legislativo, que opera de modo normativo ao respaldar as leis jurídicas que tem a possibilidade de se tornarem uma aceitação universal e atua de forma disciplinadora às normas que se encontrem em conflito com os princípios do direito.
Bioinformatic Analysis and Molecular Docking to Elucidate the
Anticancer Effect of Silver Nanoparticles in Hepatocellular Carcinoma
Authors: Martínez-Esquivias Fernando , Martínez-Perez Luz Andrea , Elena Iñiguez-Muñoz Laura , Méndez-Robles María Dolores , Guzman-Flores Juan Manuel 
Published: November 2024

Background:
Hepatocellular carcinoma is the cancer with the highest mortality rate
worldwide. Currently, existing treatments are not very effective for this disease. Different science
areas have focused on developing new therapies, including nanomedicine. In-vitro studies have
reported the anticancer activity of silver nanoparticles, particularly those coated with
polyvinylpyrrolidone (AgNPs-PVP).

Aims:
Characterize the effect of AgNPs on the HepG2 by bioinformatics analysis.

Methods:
From a list of proteins, we performed in-silico analysis to predict protein-protein
interaction, hub gene, gene ontology, KEGG pathways, hub gene expression, protein expression,
survival, cell infiltration immune, and molecular docking of AgNPs-PVP to target proteins.
Cytoscape and UCSF Chimera software, DAVID, UALCAN, TISIDB, and HDOCK databases were
included in the predictive analysis.

Results:
Gene ontology and KEGG pathways showed that AgNP exposure causes cellular
organelles dysregulation and deregulation of protein production mechanisms.
Additionally, metabolic pathways were altered, including glycolysis, gluconeogenesis, and amino
acid biosynthesis. Hub genes RPS15, RPLP0, EEF1B2, RPL12, and NACA showed differential
expression for gene expression, protein, and survival analysis. Furthermore, RPS15 and RPL12 were
positively correlated with CD8+ T cell infiltration, and RPLP0, EEF1B2, and NACA were
negatively correlated with NK cell infiltration. Finally, molecular docking showed that AgNPs-PVP
interacts highly with the target proteins.

Conclusion:
AgNPs cause alterations in cell viability. Furthermore, the deregulation of hub genes
and the modulation of the immune system are associated with anticancer effects, and molecular
docking demonstrated high interaction with the target proteins that should be studied
experimentally.
Investigating the Serum Level of Vitamin D and its Relationship with the Outcome of the Disease in Patients with COVID-19 Infection
Authors: Saeedi Amin , Morovatshoar Reza , Mohammadnahal Leila , Pooladvand Vahid , Raesi Rasoul , Hushmandi Kiavash , Daneshi Salman , Halvaee Pour Hadis 
Published: November 2024

Background
Various studies have reported that the normal level of vitamin D is related to the improvement of the prognosis of patients. Therefore, the level of vitamin D should be checked in hospitalized patients and in cases of vitamin D deficiency.

Aim
This study was conducted to investigate the serum level of vitamin D and its relationship with the outcome of the disease in hospitalized patients with COVID-19.

Methods
This is a cross-sectional study (descriptive-analytical) that examined 100 patients with COVID-19. After obtaining permission from Jiroft University of Medical Sciences, the desired data was collected using a researcher-made checklist. The data of the study was collected by the researcher visiting the inpatient wards of the COVID-19 patients. Data were analyzed using SPSS-v-22 software.

Results
The average age of the patients was 54.3 ± 24.7 years (age range 3 to 96 years), of which 53 were women and 47 were men. Only 53% of the examined patients were hospitalized, and the rest were included in the study as outpatients. The level of vitamin D in hospitalized people was significantly lower than in outpatients, the serum level of vitamin D in deceased people was lower than in other groups, and a significant relationship was found between age and vitamin D levels in people with COVID-19.

Conclusion
The results demonstrated that the frequency of vitamin D deficiency was higher in patients with COVID-19. There was a significant relationship between the average serum level of vitamin D and the severity of COVID-19 disease.