bluuebunny/crossref_metadata_2025_split huggingface dataset:
Maternal environment and craniofacial growth: geometric morphometric analysis of mandibular shape changes with in utero thyroxine overexposure in mice
Authors: Kesterke Matthew J. , Judd Margaret A. , Mooney Mark P. , Siegel Michael I. , Elsalanty Mohammed , Howie R. Nicole , Weinberg Seth M. , Cray James J. 
Published: April 2018

AbstractAn estimated 3% of US pregnancies are affected by maternal thyroid dysfunction, with between one and three of every 1000 pregnancies being complicated by overactive maternal thyroid levels. Excess thyroid hormones are linked to neurological impairment and excessive craniofacial variation, affecting both endochondral and intramembranous bone. Using a geometric morphometric approach, this study evaluates the role of in utero thyroxine overexposure on the growth of offspring mandibles in a sample of 241 mice. Canonical variate analysis utilized 16 unilateral mandibular landmarks obtained from 3D micro‐computed tomography to assess shape changes between unexposed controls (n = 63) and exposed mice (n = 178). By evaluating shape changes in the mandible among three age groups (15, 20 and 25 days postnatal) and different dosage levels (low, medium and high), this study found that excess maternal thyroxine alters offspring mandibular shape in both age‐ and dosage‐dependent manners. Group differences in overall shape were significant (P < 0.001), and showed major changes in regions of the mandible associated with muscle attachment (coronoid process, gonial angle) and regions of growth largely governed by articulation with the cranial base (condyle) and occlusion (alveolus). These results compliment recent studies demonstrating that maternal thyroxine levels can alter the cranial base and cranial vault of offspring, contributing to a better understanding of both normal and abnormal mandibular development, as well as the medical implications of craniofacial growth and development.
Associations between asthma status and radiologically confirmed fracture in children: A data‐linkage study
Authors: Degabriele Elizabeth L , Holloway Kara L , Pasco Julie A , Hyde Natalie K , Vuillermin Peter J , Williams Lana J , Brennan‐Olsen Sharon L 
Published: April 2018

AimWorld‐wide, approximately 14% of children have prevalent asthma. As most bone accrual occurs in childhood, and data suggest a detrimental role in bone from asthma and/or medications, we investigated whether asthma was associated with radiologically confirmed fractures in a large cohort of children.MethodsData from the Barwon Asthma Study (2005), a population‐based, cross‐sectional survey of all children attending 91 primary schools in the Barwon Statistical Division, were linked to the Geelong Osteoporosis Study Fracture Grid (2006–2007), a fracture register encompassing the Barwon Statistical Division (n = 16 438; 50.5% boys; aged 3.5–13.6 years). Asthma, ascertained from parent‐reported symptoms using the International Study of Asthma and Allergies in Childhood questionnaire, was categorised as: (i) recent wheeze; and number of (ii) recent wheezy episodes; (iii) doctor visits for wheeze symptoms; and (iv) doctor visits for asthma check‐ups. Using logistic regression analyses, stratified by sex and adjusted for age and medication use, we determined whether asthma was associated with radiologically confirmed fractures.ResultsIn total, 961 fractures were observed among 823 Barwon Asthma Study participants (5.9% of total sample; 61.1% boys). Recent wheeze and 1–3 recent wheezy episodes were associated with increased odds of fracture in boys (odds ratio (OR) 1.26, 95% confidence interval (CI) 1.03–1.55; OR 1.40, 95% CI 1.12–1.77, respectively), but not girls (OR 1.03, 95% CI 0.78–1.37; OR 0.67, 95% CI 0.38–1.19). Results were independent of age, and sustained after adjustment for medication.ConclusionsIndependent of age, asthma was associated with fracture for boys, but not girls. There is an imperative for strategies to promote bone health among children with asthma.
Group‐Difference Effect Sizes: Gauging the Practical Importance of Findings from Group‐Experimental Research
Authors: Cook Bryan G. , Cook Lysandra , Therrien William J. 
Published: April 2018

AbstractEffect sizes are powerful tools for evaluating the practical importance of study findings that should be considered in the context of study characteristics such as participants, dependent variables, and comparison condition. In this article, we discuss how group‐difference effect sizes are used to gauge the practical importance of group experimental studies. We first define different types of group‐difference effect sizes and discuss how they can provide valuable information for research consumers. Second, we present guidelines for interpreting group‐difference effect sizes. Third, we discuss important contextual variables that should be taken into account when interpreting group‐difference effect sizes reported in the literature. Last, we provide two examples of how group‐difference effect sizes have been used in the learning disabilities research base.
Serodiagnosis of aspergillosis in falcons (Falco spp.) by an Afmp1p‐based enzyme‐linked immunosorbent assay
Authors: Wernery Ulrich , Tsang Chi‐Ching , Hebel Christiana , Damerau Alexandra , Kinne Jörg , Cai Jian‐Piao , Küspert Harald , Chan Ka‐Fai , Joseph Marina , Xue Shaolong , Raghavan Rekha , Tang James Y. M. , Syriac Ginu , Lau Susanna K. P. , Jose Shantymol , Woo Patrick C. Y. 
Published: April 2018

SummaryAspergillosis in falcons may be associated with high mortality and difficulties in clinical and laboratory diagnosis. We previously cloned an immunogenic protein, Afmp1p, in Aspergillus fumigatus and showed that anti‐Afmp1p antibodies were present in human patients with A. fumigatus infections. In this study, we hypothesise that a similar Afmp1p‐based enzyme‐linked immunosorbent assay (ELISA) could be applied to serodiagnose falcon aspergillosis. A specific polyclonal antibody was first generated to detect falcon serum IgY. Horseradish peroxidase‐conjugate of this antibody was then used to measure anti‐Afmp1p antibodies in sera collected from falcons experimentally infected with A. fumigatus, and the performance of the Afmp1p‐based ELISA was evaluated using sera from healthy falcons and falcons with documented A. fumigatus infections. All four experimentally infected falcons developed culture‐ and histology‐proven invasive aspergillosis. Anti‐Afmp1p antibodies were detected in their sera. For the Afmp1p‐based ELISA, the mean ± SD OD450 nm using sera from 129 healthy falcons was 0.186 ± 0.073. Receiver operating characteristics curve analysis showed an absorbance cut‐off value of 0.407. One negative serum gave an absorbance outside the normal range, giving a specificity of 99.2%. For the 12 sera from falcons with confirmed aspergillosis, nine gave absorbance values ≥ cut‐off, giving a sensitivity of 75%. The Afmp1p‐based ELISA is useful for serodiagnosis of falcons with aspergillosis.
A molecular framework to study periderm formation in Arabidopsis
Authors: Wunderling Anna , Ripper Dagmar , Barra‐Jimenez Azahara , Mahn Stefan , Sajak Kathrin , Targem Mehdi Ben , Ragni Laura 
Published: April 2018

Summary

During secondary growth in most eudicots and gymnosperms, the periderm replaces the epidermis as the frontier tissue protecting the vasculature from biotic and abiotic stresses. Despite its importance, the mechanisms underlying periderm establishment and formation are largely unknown.

The herbaceous Arabidopsis thaliana undergoes secondary growth, including periderm formation in the root and hypocotyl. Thus, we focused on these two organs to establish a framework to study periderm development in a model organism.

We identified a set of characteristic developmental stages describing periderm growth from the first cell division in the pericycle to the shedding of the cortex and epidermis. We highlight that two independent mechanisms are involved in the loosening of the outer tissues as the endodermis undergoes programmed cell death, whereas the epidermis and the cortex are abscised. Moreover, the phellem of Arabidopsis, as in trees, is suberized, lignified and peels off. In addition, putative regulators from oak and potato are also expressed in the Arabidopsis periderm.

Collectively, the periderm of Arabidopsis shares many characteristics/features of woody and tuberous periderms, rendering Arabidopsis thaliana an attractive model for cork biology.
A Practical Estimation Method for Center of Mass Velocity in Swimming Direction During Front Crawl Swimming
Authors: Matsuda Yuji , Sakurai Yoshihisa , Akashi Keita , Kubo Yasuyuki 
Published: April 2018

Center of mass (CoM) velocity variation in swimming direction is related to swimming performance and efficiency. However, it is difficult to calculate the CoM velocity during swimming. Therefore, we aimed to establish a practical estimation method for the CoM velocity in swimming direction during front crawl swimming with underwater cameras. Ten swimmers were recorded during front crawl swimming (25 m, maximal effort) using a motion capture system with 18 underwater and 9 land cameras. Three CoM velocity estimation methods were constructed (single-hip velocity, both-hips velocity, and both-hips velocity with simulated arm velocity correction). Each model was validated against the actual CoM velocity. The difference between the single-hip velocity and the actual CoM velocity in swimming direction was significantly larger compared with that of the other 2 models. Furthermore, the accuracy of CoM velocity estimation was increased when both-hips velocity was corrected using the simulated arm velocity. The method allowed estimation of the CoM velocity with only 2 underwater cameras with a maximal difference of 0.06 m·s−1. This study established a novel and practical method for the estimation of the CoM velocity in swimming direction during front crawl swimming.
Awareness of the Link between Alcohol Consumption and Cancer across the World: A Review
Authors: Scheideler Jennifer K. , Klein William M.P. 
Published: April 2018

Abstract
Since 1988, the International Agency for Research on Cancer has classified alcohol as a Group 1 carcinogen, the highest level of risk. Growing evidence suggests that alcohol increases the risk of several types of cancer including breast, bowel, prostate, and liver, and accounts for a significant proportion of preventable cancers. Despite ample evidence of this relationship, public awareness is less clear. Following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, we reviewed 32 studies examining lay awareness of alcohol as a risk factor for cancer in 16 countries. Our results show that awareness appears to be low and varies internationally; it is relatively higher in the United Kingdom, Morocco, and Australia. Methodologic differences in assessment obfuscate cross-country and cross-sample comparisons. In general, people are more likely to endorse alcohol as a risk factor when presented with a list of possible risk factors than when asked to list risk factors in an open-ended format. Attempts to increase awareness have been limited and constitute a significant public health need. We provide potential strategies to increase awareness, such as alcohol bottle labeling and fostering patient/physician discussions regarding the link. Cancer Epidemiol Biomarkers Prev; 27(4); 429–37. ©2018 AACR.
Pathogenicity of four entomopathogenic nematode strains against Asian corn borer, Ostrinia furnacalis (Guenée), in Vietnam
Authors: Nguyen Chau N. , Do Anh T. , Hoang Phuc K. , Truong Lam X. 
Published: April 2018

Summary
The virulence and reproductive capacity of four indigenous entomopathogenic nematode (EPN) strains, S-PQ16 (Steinernema sp. PQ16), S-TX1 (Steinernema sangi TX1), S-DL13 (S. siamkayai DL13) and H-NT3 (Heterorhabditis indica NT3), against the last instar larvae of Asian corn borer (ACB), was evaluated. With moderately low concentrations of infective juveniles (IJ) from 10 to 100 IJ insect−1, the ACB larvae were found to be susceptible to all four EPN nematode strains after exposure for 24, 48, 72, 96 and 120 h. The 100% mortality of ACB larvae by these indigenous EPN strains occurred after 96-120 h of exposure. The low LC50 values (between 21.7 and 27.9 IJ) indicated the high virulence of these four EPN strains to ACB larvae. The highest yield of IJ produced inside the insect cadavers for S-PQ16, S-TX1, S-DL13 and H-NT3 was 215.0 ± 6.5 × 103, 83.1 ± 4.9 × 103, 67.8 ± 7.2 × 103 and 225.2 ± 6.4 × 103 IJ, respectively, with low inoculated concentrations of between 30-50 IJ. The results, showing a high degree of virulence and high reproduction capacity, suggest that these indigenous EPN strains have great potential for biological control of the Asian corn borer.
SOX11 augments BCR signaling to drive MCL-like tumor development
Authors: Kuo Pei-Yu , Jatiani Shashidhar S. , Rahman Adeeb H. , Edwards Donna , Jiang Zewei , Ahr Katya , Perumal Deepak , Leshchenko Violetta V. , Brody Joshua , Shaknovich Rita , Ye B. Hilda , Parekh Samir 
Published: April 2018

Key Points
B-cell–specific overexpression of SOX11 promotes oncogenic proliferation of B1a B cells and drives an MCL-like phenotype. SOX11 overexpression is associated with increased signaling through the BCR pathway that can be reversed by pharmacological BTK inhibition.
The possible implications of advances in genetic testing technologies for Genetic Counsellors working with families of children with developmental disorders
Authors: Joseph Flora M. 
Published: April 2018

New genetic testing technologies such as microarrays and whole exome sequencing mean the diagnostic potential for a child with a development disorder is greatly increased over traditional testing techniques. With this increased potential comes increased expectations from families and professionals about the answers a diagnosis will provide. However, limitations remain and a proportion of individuals will continue to remain undiagnosed. In addition, some individuals will receive novel or very rare diagnoses about which very little is known in terms of prognosis and effective treatments. In this paper, I present an argument for why these families would benefit from additional Genetic Counsellor support and how Clinical Genetics services in the UK could provide this support. I acknowledge that resources are limited, but as demands on services increase and interactions with families become shorter, I argue that these resources should be fought for, for the benefit of these families.
RITOS DE VELÓRIO E SEPULTAMENTO DE CRIANÇAS NA HISTÓRIA DA INFÂNCIA EM BELÉM DO PARÁ - 1910-1914
Authors: Viana Carmeci Dos Reis , Araújo Alves Laura Maria Silva 
Published: April 2018

Trata-se de inserções iniciais da pesquisa que está sendo desenvolvida no Mestrado Acadêmico em Educação. Investiga os rituais de velório e sepultamento de crianças em Belém do Pará (1910 e 1914), a partir de impressos jornalísticos que retratam as práticas, crenças e superstições, que perfaziam o ritual de despedida da criança na morte. É Pesquisa documental. Questões levantadas 1) Como se constituíam os rituais de velório e sepultamento de crianças em Belém do Pará no período em tela? 2) Qual a sua relação com a veneração da alma, o saber local e a miscigenação das culturas para a constituição da infância e dos conceitos de infância na região? Resultados preliminares apontam que a demografia da mortalidade infantil, os rituais de preparo do corpo, o velório e o sepultamento dos infantes estão ligados a questões de ordem social econômica e religiosa. Palavras chave: História da infância no Pará. Ritos de mortalidade. Infância na Amazônia.
Gestos (im)prováveis: ocupações e(m) afecções...
Authors: Andrade Elenise Cristina Pires de , Almeida Edivan Carneiro , Brandão Elenilda Alves 
Published: April 2018

Viralizar a vida junto aos movimentos maquínicos que se estendem e distendem dois processos de pesquisa realizados em escolas públicas baianas entre os anos de 2014 e 2016: o projeto “Cidades (des)enquadradas em imagens: experimentações (atra)versando o conceito de signo” que, aqui, apresentará algumas divagações nas relações entre as produções de imagens com alunos do ensino médio de uma escola pública em Ichu-BA e a dissertação de mestrado “Você tem fome de quê?: movimentos (e)m currículos de uma escola do ensino médio em Ipiaú, Bahia” (2017). Esse texto, portanto, tem a vontade de explorar ideias e ressonâncias e movimentos das filosofias da diferença que nos acompanharão e invadirão esta escrita na vontade de revirar a questão: quais gestos ocupariam as ruas-cidades em um devir intensivo, a provocar fendas no movimento maquínico da enunciação nos muros-escolas, nas fotografias, nas palavras, disparando forças criativas?
LEUCEMIA DE CÉLULAS PLASMOCITÁRIAS COM NEUTROPENIA FEBRIL: UM RELATO DE CASO
Authors: Santos Sheezara Teles Lira dos , Nascimento Samia Israele Braz do , Costa Maxsuel Rolim da 
Published: April 2018

Introdução: A Leucemia de Células Plasmocitárias (LCP) é uma desordem linfoproliferativa rara – representa de 1 a 2% do total das neoplasias hematológicas-, caracterizada pela presença de plasmócitos absolutos de mais de 2x109 células ou mais de 20% de células plasmáticas no sangue periférico. Apresenta dois quadros: primária, leucemia no momento do diagnóstico, e secundária, consequência da transformação de um mieloma múltiplo conhecido. Acomete mais o sexo feminino, com prevalência entre 50 e 70 anos. Entre as manifestações clínicas, observam-se lesões líticas, fraturas patológicas, hepatoesplenomegalia, entre outros. É uma doença agressiva e com má resposta ao tratamento, com sobrevida média de 18 a 20 meses. A Neutropenia Febril é considerada uma emergência oncológica, representada pela ocorrência de febre em pacientes em tratamento quimioterápico com contagem de neutrófilos menor que 500/mm3. Objetivo: Relatar o caso de uma paciente portadora de Leucemia de Células Plasmocitárias que evoluiu com Neutropenia Febril. Descrição do caso: Trata-se de uma paciente, S.G. S., 59 anos, sexo feminino, admitida na Unidade de Terapia Intensiva (UTI), proveniente da Enfermaria Oncológica, onde estava internada há 7 dias com quadro de Febre e Dispneia e suspeita de Neutropenia Febril. É portadora de Leucemia de Células Plasmocitárias e estava no 1º ciclo de Quimioterapia, sem outras comorbidades. Evoluiu com rebaixamento do nível consciência, quando foi intubada. Foram repostos 2 concentrados de hemácias, por queda do hematócrito, mas sem evidências de sangramento. Além disso, a paciente evoluiu com disfunção renal(Cr 2,3 mg% e Ureia 161 mg%) e distúrbios eletrolíticos (hipomagnesemia, hipocalcemia e hipofosfatemia). Realizou TC de Crânio que evidenciou espessamento mucoso em seio esfenoidal esquerdo. Fez uso de Cefepime, Bactrin, Metronidazol, Aciclovir profilático. Ficou por 15 dias na UTI, quando foi a óbito por parada cardiorrespiratória. Conclusão: A Leucemia de Células Plasmocitárias ainda continua sendo um grande desafio para a oncologia, sobretudo em casos de emergência como o caso descrito. Mesmo com o diagnóstico e tratamento precoce, o estado crítico da paciente pode interferir negativamente no desfecho final.
MAIS UMA DICOTOMIA GEOGRÁFICA: ENTRE BACHARELADO E LICENCIATURA... UMA FALSA QUESTÃO? / Another Geographical Dichotomy: Between Bachelor Degree and Licenciate Degree... A False Issue?
Authors: Batista Sinthia Cristina 
Published: April 2018

O presente artigo objetiva enunciar os atuais processos de reestruturação da Universidade Brasileira e seus desdobramentos no desenvolvimento da formação do Geógrafo no Brasil. A partir de uma questão concreta, a cisão no processo de formação do Geógrafo de suas habilitações profissionais – a Licenciatura e o Bacharelado em diferentes Universidades Públicas no país, pretende-se levantar questões à comunidade geográfica que reforcem a necessidade de discutir e posicionar-se mediante seu processo de formação e atuação profissional frente à acepção que constitui a Universidade no Brasil.Palavras-Chave: Formação do Geógrafo; Reformas educacionais; Universidade Pública ABSTRACTThis article aims to outline the current restructuring of the Brazilian University and its consequences in the development of training Geographer in Brazil. From a factual matter, the split in the Geographer of the training process of their professional qualifications - the Degree and Bachelor of different public universities in the country, is intended to raise questions to the geographical community that reinforce the need to discuss and position yourself through the process of training and professional intervention to face a meaning which is the University in Brazil.Key-Words: Geographer training; Educational reform; Public University
CONFLITO TRABALHO-FAMÍLIA, POLÍTICAS DE APOIO À FAMÍLIA E GÊNERO: UM PANORAMA DO ATUAL CENÁRIO DE ESTUDOS/WORK-FAMILY CONFLICT, FAMILY AND GENDER SUPPORT POLICY: A PANORAMA OF THE CURRENT SCENARIO OF STUDIES
Authors: Silva Vilela Nágila Giovanna , Lourenço Mariane Lemos 
Published: April 2018

A dificuldade em conciliar as demandas do trabalho e da família tem contribuído para que homens e mulheres regularmente enfrentem conflitos entre essas duas esferas. O conflito trabalho-família, decorrente da incompatibilidade de pressões de papéis profissionais e familiares vem sendo o cerne de diversos trabalhos, principalmente na literatura internacional. Visando reduzir os impactos negativos causados por tais conflitos, as organizações e os governos de vários países têm proposto políticas para auxiliar na harmonia entre trabalho e família. Diante disso, o objetivo desse trabalho é analisar como as políticas de apoio à família que visam reduzir o conflito trabalho-família se diferem entre países e de acordo com o gênero, tanto no que diz respeito à oferta, quanto à sua utilização. Para atingir esse propósito, foi feita uma pesquisa bibliográfica em periódicos de destaque (como Employee Relations, Equality, Diversity and Inclusion, Human Resource Management, Journal of Family Issues, Personnel Review, Revista de Administração Contemporânea, entre outros) com publicações sobre a temática nos últimos anos. Foi possível verificar a importância do contexto social para a compreensão dessas políticas e como elas são percebidas pelos trabalhadores.
Invertebrate Synapsins: A Single Gene Codes for Several Isoforms inDrosophila
Authors: Klagges Bert R. E. , Heimbeck Gertrud , Godenschwege Tanja A. , Hofbauer Alois , Pflugfelder Gert O. , Reifegerste Rita , Reisch Dietmar , Schaupp Michael , Buchner Sigrid , Buchner Erich 
Published: April 2018

Vertebrate synapsins constitute a family of synaptic proteins that participate in the regulation of neurotransmitter release. Information on the presence of synapsin homologs in invertebrates has been inconclusive. We have now cloned aDrosophilagene coding for at least two inferred proteins that both contain a region with 50% amino acid identity to the highly conserved vesicle- and actin-binding “C” domain of vertebrate synapsins. Within the C domain coding sequence, the positions of two introns have been conserved exactly from fly to human. The positions of three additional introns within this domain are similar. TheDrosophilasynapsin gene (Syn) is widely expressed in the nervous system of the fly. The gene products are detected in all or nearly all conventional synaptic terminals. A single amber (UAG) stop codon terminates the open reading frame (ORF1) of the most abundant transcript of theSyngene 140 amino acid codons downstream of the homology domain. Unexpectedly, the stop codon is followed by another 443 in-frame amino acid codons (ORF2). Using different antibodies directed against ORF1 or ORF2, we demonstrate that in the adult fly small and large synapsin isoforms are generated. The small isoforms are only recognized by antibodies against ORF1; the large isoforms bind both kinds of antibodies. We suggest that the large synapsin isoform inDrosophilamay be generated by UAG read-through. Implications of such an unconventional mechanism for the generation of protein diversity from a single gene are discussed.