bluuebunny/crossref_metadata_2025_split huggingface dataset:
Harmonising Science and Religion in the Life of Generation Z in Indonesia: Efforts Towards Social and Cultural Integration
Authors: Marchella Dika Aristawidya  
Published: November 2024

Research Background: This research focuses on how Generation Z in Indonesia integrates science and religion in their lives, seeing this phenomenon as a reflection of significant social and cultural shifts.
Method: Using an analytical descriptive methodology, this research examines the interaction between science and religion through the lens of younger generations in Indonesia, considering the influence of education and social media.
The main findings: Generation Z tends to approach science and religion in a more integrated and inclusive manner, exploring and accepting both domains as part of a holistic understanding of the world.
Contribution: a deepened understanding of how younger generations can reconcile different perspectives on science and religion, directing educational policy to support a more coherent approach. The research suggests the importance of education that supports intellectual openness and cultural tolerance as a way to facilitate better integration between science and religion, not only in academic contexts but also in everyday life.
Conclusion: Generation Z, with its openness and critical ability, has the potential to be an agent of change in harmonising science and religion.
El Cuidado Humanizado De Enfermería En Un Hospital Del Sur Ecuatoriano
Authors: Ponce Varela Yuly Mar , Contreras Briceño José Ivo 
Published: November 2024

El cuidado humanizado es un imperativo moral de la práctica en enfermería. El objetivo general de esta investigación fue analizar las características del cuidado humanizado que proveen los profesionales de enfermería en tres servicios de un hospital ecuatoriano: medicina interna, cirugía general, así como de ginecología y obstetricia. La investigación es de tipo observacional, transversal y analítica, la muestra estuvo conformada por 156 pacientes del total recluido que manifestaron participar en el estudio. El Cuestionario aplicado fue el de Percepción del Cuidado Humanizado en Enfermería (PCHE 3A VERSIÓN) versión (González-Hernández, 2015) que permitió valorar la percepción del cuidado humanizado, se compone de 32 ítems, distribuidos en tres dimensiones: Cualidades del que hacer (7 preguntas), apertura a la comunicación (8 preguntas) y priorizar al sujeto (17 preguntas). El procesamiento de los datos se sistematizó mediante el aplicativo Jamovi y se aplicaron métodos estadísticos descriptivos, ANOVA de una vía, el test de diferencia mínima significativa y la prueba Chi Cuadrado de Pearson con corrección de continuidad. Antes de su aplicación los participantes firmaron el consentimiento informado aprobado por un Comité de Ética. Resultados: La percepción general de los usuarios es que “casi siempre” perciben cuidado humanizado al igual que en las tres dimensiones. Esta percepción es mayor en el servicio de Ginecología y Obstetricia y menor en Cirugía General. Se encontró diferencia estadísticamente significativa (-0.001) entre el género y servicios respecto a las dimensiones cualidades del que hacer, priorizar al sujeto y de manera global. Se concluye que el cuidado humanizado está presente “casi siempre” y que el género y el tipo de servicio hospitalario influyen significativamente en la percepción del cuidado humanizado.
ESTUDO COMPARATIVO DO ESTILO DE VIDA ATIVO E FATORES ASSOCIADOS NA PREVALÊNCIA DOS TRANSTORNOS DE DEPRESSÃO EM ACADÊMICOS DE EDUCAÇÃO FÍSICA E DEMAIS CURSOS DA ÁREA DA SAÚDE: UM ESTUDO BIBLIOGRÁFICO
Authors: Medino Ana Leticia Sales , Carvalho Leyla Regis de Meneses Sousa 
Published: November 2024

Introdução: A depressão é uma doença multifatorial que pode surgir em qualquer período da vida, produzindo alterações no humor caracterizada por tristeza profunda e forte sentimento de desesperança. Objetivo: Comparar o estilo de vida ativo e fatores associados na prevalência dos transtornos de depressão em acadêmicos de educação física e demais cursos da área da saúde. Métodos: Trata-se de uma revisão bibliográfica do tipo integrativa, realizadas nas bases de dados: Biblioteca Virtual em Saúde (BVS) e Pubmed, Scientific Eletronic Library Online (SciELO). Utilizando de forma isolada e/ou conjugada os seguintes descritores: Depressão em jovens; Depressão em universitários; Depressão e exercício físico; Depressão e atividade física. Resultados: Os dados apontaram que os acadêmicos que mantém um estilo de vida ativo manifestaram menores índices de sintomas depressivos, além disso, foram identificados alguns fatores associados à depressão neste grupo como: situações relacionadas às novas regras acadêmicas, pressão e carga excessiva de estudos, exigências sociais de maior autonomia dentre outros, fatores esses que contribuem de forma massiva para desencadear esse transtorno. Considerações: Neste sentido, a prática de exercícios físicos se mostra benéfica no tratamento e melhorias da capacidade física e psicológica, posto que, quando devidamente orientados os exercícios tendem a influenciar de forma positiva no estado de humor, proporcionando inúmeros benefícios, desempenhando tanto papel preventivo quanto auxiliando no tratamento dos sintomas e consequentemente promovendo aumento na autoestima e estado psicossocial favorável. Sugere-se que tenham mais estudos comparando a prevalência de depressão por área de estudo, uma vez que, este grupo em especial merece atenção e cuidados.
Cuidados de Enfermería en Pacientes Pediátricos Crónicos Complejos y la Aplicación del Dispositivo Leandro en un Estudio de Caso
Authors: Quipe-Apaza Soledad , Vargas-Vilela Miriam , Veizaga-Arias Judith , Lanza-Morales Aida 
Published: November 2024

Antecedentes: Los cuidados de enfermería en pacientes pediátricos crónicos complejos presentan un desafío importante en la actualidad. Este estudio presenta una primera experiencia en la aplicación del dispositivo Leandro en un paciente pediátrico crónico complejo. Objetivo: Describir el impacto de los cuidados de enfermería en un paciente pediátrico con condición crónica compleja portador del dispositivo Leandro, basado en un caso clínico. Método: El estudio es de carácter exploratorio, descriptivo y de corte transversal. Se presenta el caso de una paciente pediátrica crónica compleja con cardiopatía congénita, hospitalizada en la Unidad de Cuidados Intensivos del Hospital del Niño Dr. Ovidio Aliaga Uría en La Paz, Bolivia. Resultados: Los cuidados de enfermería implementados con la utilización del dispositivo Leandro fueron evaluados en términos de su impacto en la calidad de vida y manejo del paciente pediátrico en estado crítico. Conclusiones: Los cuidados de enfermería en pacientes pediátricos crónicos complejos en Bolivia, específicamente en la ciudad de La Paz, son comparables a los estándares internacionales. El caso clínico fue descrito según la clasificación del Clinical Risk Group, destacando la importancia del rol de la enfermería en el manejo integral del paciente crítico.
MALAT1 promotes colonic epithelial cell apoptosis and pyroptosis by sponging miR-22-3p to enhance NLRP3 expression
Authors: Yan Rong , Liang Xinghua , Hu Juan 
Published: November 2024

Background
Colonic epithelial cell apoptosis and pyroptosis had a close relationship with the pathological progression of ulcerative colitis (UC). LncRNA play a crucial role in the progression of UC. However, the role of the lncRNA MALAT1 in colonic epithelial cell apoptosis and pyroptosis remains unclear.

Methods
UC colitis cell model was established through lipopolysaccharide (LPS) treatment. MiR-22-3p and MALAT1 expression in fetal human colon (FHC) cells were analyzed by qRT-PCR. Proliferation and apoptosis of FHCs were measured using CCK-8 assay and flow cytometry, respectively. Pyroptosis indicators including interleukin (IL)-1β, IL-18, tumor necrosis factor-α (TNF-α), NLR family pyrin domain containing 3 (NLRP3), caspase-1, and N-gasdermin D (N-GSDMD) in FHCs were detected using ELISA, qRT-PCR, western blotting, and immunofluorescence.

Results
In this study, apoptosis was facilitated, IL-1β, IL-18, and TNF-α levels were enhanced, NLRP3, caspase-1, N-GSDMD protein were increased, and MALAT1 expression was markedly increased in LPS-treated FHCs (LTFs). MALAT1 knockdown remarkably facilitated proliferation and suppressed apoptosis, reduced IL-1β, IL-18, and TNF-α levels, and decreased the protein of NLRP3, caspase-1, N-GSDMD. Furthermore, NLRP3 overexpression remarkably reversed the effect of MALAT1-downexpression in LTFs. In addition, miR-22-3p could bind with MALAT1 and NLRP3 3′ UTR. Furthermore, miR-22-3p inhibition remarkably reversed the effect of MALAT1 overexpression in LTFs.

Conclusions
These findings suggest that MALAT1 represents a promising therapeutic target for the treatment of UC by modulating the miR-22-3p/NLRP3 pathway, potentially leading to novel strategies for reducing inflammation and cell death in the colon.
Risk factors for postoperative hypokalemia in patients undergoing endoscopic pituitary adenoma resection: a retrospective cohort study
Authors: Li Maoxiang , Mo Changhong , Yan Sifan , Zhao Ruijing , Luo Weijian , Yang Lu , Wang Hao , Hu Jiliang 
Published: November 2024

Background
Currently, endoscopic transsphenoidal surgery is the primary approach for treating pituitary tumors. While endoscopic surgery offers numerous advantages, it also comes with a series of potential surgical complications. Postoperative hypokalemia is a common complication, with mild cases presenting with atypical symptoms such as dizziness, headache, fatigue, and constipation, while severe cases can lead to arrhythmias, rhabdomyolysis, and even death. Therefore, early identification of risk factors for postoperative hypokalemia is crucial. This study aims to analyze the risk factors for hypokalemia after endoscopic pituitary tumor resection.

Methods and Materials
This study included 168 patients who underwent endoscopic resection of pituitary tumors between 2019 and 2023. Patients were divided into hypokalemia group and non-hypokalemia group based on whether their postoperative serum potassium concentration was less than 3.0 mEq/L. Identifying independent risk factors through binary logistic regression analysis.

Results
Among the 168 patients, 18 (10.7%) cases experienced postoperative hypokalemia, with the majority occurring on the fourth day after surgery. The majority of patients did not exhibit clinical symptoms related to hypokalemia. The binary logistic regression analysis revealed that age (OR 1.09; 95% CI [1.03–1.15]; P = 0.001) and postoperative hypoalbuminemia on the first day (OR, 4.35; 95% CI [1.38–13.75]; P = 0.012) were associated with postoperative hypokalemia.

Conclusions
Patients aged ≥50 years and those presenting with hypoalbuminemia on the first postoperative day were more likely to develop postoperative hypokalemia. Therefore, electrolyte monitoring should be enhanced in such patients postoperatively, especially to actively prevent hypokalemia on the 4th–5th postoperative day.
β-Defensin versus conventional markers of inflammation in periprosthetic joint infection: a retrospective study
Authors: Fernández-Torres Javier , Zamudio-Cuevas Yessica , Martínez-Flores Karina , López-Macay Ambar , Rosas-Alquicira Graciela , Martínez-Zavaleta María Guadalupe , López-Jácome Luis Esaú , Franco-Cendejas Rafael , Roldan-Valadez Ernesto 
Published: November 2024

Background
Diagnosing periprosthetic joint infection (PJI) remains a significant challenge for healthcare professionals. Commonly utilized inflammatory markers include erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), and white blood cells (WBC). Human β-defensin 1 (β-defensin) is an antimicrobial peptide elevated in infection, yet its diagnostic value for PJI has not been explored. The purpose of this study was to evaluate the efficacy of synovial β-defensin as a diagnostic marker for PJI and to compare its performance with ESR, serum CRP, and WBC.

Methods
We conducted a single-center retrospective study from October 2022 to June 2023. A total of 105 joint fluid samples from revision patients at the Instituto Nacional de Rehabilitación Luis Guillermo Ibarra Ibarra were collected intraoperatively (71 hips, 34 knees) and frozen. According to MSIS criteria, 64 patients were defined as positive for PJI and the remaining 41 were negative. Synovial β-defensin levels were quantified using ELISA, serum CRP levels by immunoturbidimetry, and blood ESR and WBC were analyzed. Sensitivity and specificity were determined using ROC curves, and diagnostic performance was compared using the area under the curve (AUC). Cut-off values for diagnosing PJI were established.

Results
Levels of synovial β-defensin, ESR, serum CRP, and WBC were significantly higher in the PJI group compared to the non-PJI (P < 0.0001). The AUCs were 0.948 for β-defensin, 0.884 for ESR, 0.902 for CRP, and 0.767 for WBC, with a combined AUC of 0.994. Sensitivity/specificity for β-defensin, ESR, CRP, and WBC were 0.966/0.830, 0.887/0.791, 0.930/0.771, and 0.820/0.682, respectively. Optimal predictive cut-off values were 1105.8 pg/mL for β-defensin, 11.5 mm/h for ESR, 5.55 mg/L for CRP, and 7.3 × 103/mm3 for WBC.

Conclusion
The synovial β-defensin assay demonstrated greater sensitivity and specificity for the diagnosis of PJI compared to ESR, serum CRP and WBC. Therefore, β-defensin shows promise as a diagnostic marker for PJI. Simultaneous determination of all markers may increase diagnostic confidence.
Characterization of Tomato Leaf Curl New Delhi Virus Associated with Leaf Curl and Yellowing Disease of Bitter Gourd from Karnataka, India
Authors: Purushotham Pooja , Nagaraju N. , Padmaja A. S. , Nateshan H. M. , Nagesha S. N. , Rakhonde Gaurav , Srinivasa Bukya 
Published: November 2024

Aims: The objective of this study was to identify the ToLCNDV isolate responsible for leaf curl and yellowing disease in bitter gourd crops in Karnataka, India.
Study Design: Molecular characterisation and transmission study.
Place and Duration of Study: The laboratory studies were conducted in the Department of Plant Pathology, College of Agriculture, University of Agricultural Sciences, GKVK, Bangalore-560065.
Methodology: The sample was collected and subjected to molecular characterization using specific primer for ToLCNDV and sent for sequencing. Vector and sap transmission studies were also carried out.
Results: PCR-mediated detection revealed the presence of ToLCNDV, although it was not coupled with any satellite molecules. The partial genome sequencing of the AV1 gene revealed more than 97% similarity with ToLCNDV isolates. The isolate under investigation was identified as a ToLCNDV isolate and given the name ToLCNDV_GKVK_BT due to high sequence identities and phylogenetic links between the incomplete DNA-A genome and ToLCNDV isolates. The transmission experiments demonstrated that it was effectively transmitted via vector and sap transfer.
Conclusion: This study identified the ToLCNDV isolate responsible for leaf curl and yellowing disease in bitter gourd crops in Karnataka, India. Identifying, characterizing at the molecular level, and understanding the transmission of begomoviruses are essential steps in developing effective management approaches to minimize agricultural losses caused by these viruses. Therefore, these findings are important for identifying the leaf curl disease of bitter gourd.
Response of Guava (Psidium guajava L.) to Pruning Intensities and Foliar Application of Nutrients on Growth Attributes
Authors: Anjanawe S R , Pandey S K , Pandey C S , Nair Reena , Sharma Asheesh 
Published: November 2024

The experiment was conducted on nine year old well-established guava orchard planted at 3.0 × 3.0 m spacing to study the response of foliar feeding of nutrients and pruning intensities on the growth attributes of guava (Psidium guajava L.) cv. Allahabad Safeda during 2022-23 and 2023-24 at Horticultural orchard at Powarkheda, Narmadapuram under the Department of Horticulture, College of Agriculture, JNKVV Jabalpur (M.P.). The experiment was laid out in Factorial Randomized Block Design (FRBD) with three replications. The treatment consist of two factor (A) three levels of pruning, i.e. No pruning (P0), pruning of 25cm shoot from tip (P1), pruning of 50cm shoot from tip (P2) and factor ( B) thirteen levels of nutrients No- Control, N1-Urea @ 2%, N2- Urea @ 3%, N3-Nano urea @ 0.2% N4- Nano urea @0.3%,N5 –Zinc @ 0.4%,N6- Zinc @ 0.6%,N7- Nano zinc @ 0.04%, N8-Nano zinc @ 0.06%, N9- Iron @ 0.3%,N10-Iron @ 0.5%,N11-Nano iron @ 0.03%,N12-Nano iron @0.5%. The results revealed that the maximum increase in - plant height (11.85%), plant spread N-S (12.77%), plant spread E-W (13.76%), length of new sprout (16.87cm) & (30.85cm) and diameter of new sprout (2.57mm) & (3.47mm) at 60 and 90 days after pruning (DAP) respectively were recorded in P2 (pruning of 50cm shoot from tip). While, minimum was observed under treatment N0 (no pruning). With respect to foliar application of nutrients, the maximum increase in plant height (11.13%), plant spread N-S (12.23%), plant spread E-W (13.33%), length of new sprout (16.18cm) & (30.16cm) and diameter of new sprout (2.53mm) & (3.45mm) at 60 and 90 DAP respectively were recorded in N2 (Urea @3%) and minimum was found in N0 (control). Among, the treatment combinations, P2N2 (pruning of 50cm shoot from tip + Urea @ 3%) was found most superior with respect to the maximum, increase in plant height (12.50%), plant spread N-S (13.40%), plant spread E-W (14.83%), length of new sprout (17.68cm) & (31.65cm) and diameter of new sprout (2.71mm) & (3.61mm) at 60 and 90 DAP respectively.
Surface Modification of Polymers: Methods and Applications
Authors: Nemani Srinivasa Kartik , Annavarapu Rama Kishore , Mohammadian Behrouz , Raiyan Asif , Heil Jamie , Haque Md. Ashraful , Abdelaal Ahmed , Sojoudi Hossein 
Published: November 2018

AbstractLow cost, controlled crystallinity, chemical, and mechanical stability enable application of polymers in energy, water, electronics, and biomedical industries. Recent studies have shown that tailoring surface properties of polymers impacts their durability and functionality in these applications. However, the functionality and performance of polymer‐based devices and systems are greatly affected by the modification method and the process parameters, highlighting the need for understanding these methods and their mechanisms of operation in detail. The selection of the modification method invariably decides the properties enhanced in the polymer. In this review, various polymer surface modification treatments are discussed. These methods are categorized into physical, chemical, thermal, and optical ways, while illustrating their advantages and disadvantages. This review also explores the surface modification of polymers by patterning which encompasses one or more surface treatment methods. An application‐oriented study is presented discussing the relative importance of a method pertaining to a specific field of end‐application.
Detection of CTC Clusters and a Dedifferentiated RNA‐Expression Survival Signature in Prostate Cancer
Authors: Kozminsky Molly , Fouladdel Shamileh , Chung Jae‐Seung , Wang Yugang , Smith David C. , Alva Ajjai , Azizi Ebrahim , Morgan Todd , Nagrath Sunitha 
Published: November 2018

AbstractRates of progression and treatment response in advanced prostate cancer are highly variable, necessitating non‐invasive methods to assess the molecular characteristics of these tumors in real time. The unique potential of circulating tumor cells (CTCs) to serve as a clinically useful liquid biomarker is due to their ability to inform via both enumeration and RNA expression. A microfluidic graphene oxide‐based device (GO Chip) is used to isolate CTCs and CTC clusters from the whole blood of 41 men with metastatic castration‐resistant prostate cancer. Additionally, the expression of 96 genes of interest is determined by RT‐qPCR. Multivariate analyses are conducted to determine the genes most closely associated with overall survival, PSA progression, and radioclinical progression. A preliminary signature, comprising high expression of stemness genes and low expression of epithelial and mesenchymal genes, potentially implicates an undifferentiated CTC phenotype as a marker of poor prognosis in this setting.
In vitro characteristics of an airway barrier‐disrupting factor secreted by Staphylococcus aureus
Authors: Murphy Jae , Ramezanpour Mahnaz , Drilling Amanda , Roscioli Eugene , Psaltis Alkis James , Wormald Peter‐John , Vreugde Sarah 
Published: November 2018

BackgroundStaphylococcus aureus is a major contributor to the pathophysiology of chronic rhinosinusitis (CRS). Previous research has shown that S. aureus–secreted products disrupt the airway barrier.MethodsS. aureus ATCC 13565 and 25923 strains were grown at exponential, postexponential, and stationary phases. Microbial conditioned media (CM) was collected from the cultures and ultrafiltered (UF). Liquid chromatography–electrospray ionization tandem mass spectrometry (LC‐ESI‐MS/MS) was performed on the UF‐CM. UF‐CM was subjected to heat and protease treatment, size fractionation, and ultracentrifugation (UC) separation. Human nasal epithelial cells grown at air‐liquid interface (HNEC‐ALI) cultures were exposed to purified alpha hemolysin (Hla), staphylococcal enterotoxin A (SEA), lipoteichoic acid (LTA), and UF‐CM. Barrier function outcomes were measured by transepithelial electrical resistance (TEER) and apparent permeability (Papp). UC fraction exposed cultures were subjected to immunofluorescence microscopy for tight junction (TJ) protein zonula occludens‐1 (ZO‐1).ResultsLC‐ESI‐MS/MS identified 107 proteins, with Hla being most abundant. Hla, SEA, and LTA did not alter the HNEC‐ALI barrier as measured by TEER or Papp. Barrier disruption caused by UF‐CM peaked in the postexponential phase, was sensitive to heat and protease treatment, >30‐kDa in size, and enriched in the UC fraction. HNEC‐ALI exposed to UF‐CM and UC demonstrated loss of ZO‐1 localization.ConclusionThese results suggest that the S. aureus factor responsible for TJ disruption in HNEC‐ALI cultures is either a protein‐macromolecule or a combination of secreted factors. The product is enriched in the UC fraction, suggesting it is associated with large structures such as membrane components or vesicles.
PHBV/TPU/cellulose compounds for compostable injection molded parts with improved thermal and mechanical performance
Authors: Sánchez‐Safont Estefanía Lidón , Arrillaga Alex , Anakabe Jon , Gamez‐Perez Jose , Cabedo Luis 
Published: November 2018

ABSTRACTPoly(hydroxybutyrate‐co‐valerate) (PHBV) is a biopolymer that has gained a lot of attention because of its biodegradability, good thermal resistance, and balanced mechanical properties with respect to some commodity plastics. However, it presents two big limitations that hinder its potential application in replacing plastics for rigid injected parts: high cost and low toughness. Aiming at overcoming these limitations, the use of two additives in a PHBV matrix was explored: thermoplastic polyurethane (TPU) as an impact modifier and cellulose as reinforcing filler. Compounds of PHBV with different TPUs and cellulose contents were prepared by extrusion and, subsequently, injection molding. The morphology, thermal, and mechanical properties of the so‐obtained materials were analyzed. Also, the biodisintegrability under standard composting conditions of the studied compositions was also assessed. The results of this work show that the obtained PHBV/TPU/cellulose compounds are biodisintegrable and show balanced properties in terms of thermal resistance–stiffness–toughness. These properties point these compounds as potential candidates to replace commodities in rigid part applications that require biodisintegration in their end‐of‐life, being able to be processed in a conventional injection molding industrial facility. © 2018 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 47257.