bluuebunny/crossref_metadata_2025_split huggingface dataset:
Quantitation of Cannabinoids in Breath Samples Using a Novel Derivatization LC–MS/MS Assay with Ultra-High Sensitivity
Authors: Luo Yiqi Ruben , Yun Cassandra , Lynch Kara L 
Published: February 2019

Abstract
As the legalization of medical and recreational marijuana use expands, measurement of tetrahydrocannabinol (THC) in human breath has become an area of interest. The presence and concentration of cannabinoids in breath have been shown to correlate with recent marijuana use and may be correlated with impairment. Given the low concentration of THC in human breath, sensitive analytical methods are required to further evaluate its utility and window of detection. This paper describes a novel derivatization method based on an azo coupling reaction that significantly increases the ionization efficiency of cannabinoids for LC–MS/MS analysis. This derivatization reaction allows for a direct derivatization reaction with neat samples and does not require further sample clean-up after derivatization, thus facilitating an easy and rapid “derivatize & shoot” sample preparation. The derivatization assay allowed for limits of quantitation (LOQ’s) in the sub-pg/mL to pg/mL range for the five cannabinoids in breath samples, i.e., only 5~50 femtograms of an analyte was required for quantitation in a single analysis. This ultrahigh sensitivity allowed for the quantitation of cannabinoids in all breath samples collected within 3 hours of smoking cannabis (n = 180). A linear correlation between THC and cannabinol (CBN) in human breath was observed, supporting the hypothesis that CBN is converted from THC during the combustion of cannabis. The derivatization method was also applied to the analysis of cannabinoids in whole blood samples, achieving LOQ’s at ten-pg/mL to sub-ng/mL level. This azo coupling-based derivatization approach provided the needed analytical sensitivity for the analysis of THC in human breath samples using LC–MS/MS and could be a valuable tool for the analysis of other aromatic compounds in the future.
Insect Exclusion Screens Reduce Cucumber Beetle Infestations in High Tunnels, Increasing Cucurbit Yield
Authors: Ingwell Laura L , Kaplan Ian 
Published: February 2019

Abstract
As high tunnel vegetable production acreage increases in the United States, so does the need for management strategies tailored to their unique growing environment. Cucumbers are an ideal crop in these systems; they can be vertically trellised to maximize the production area and provide high yields to balance the increased costs associated with high tunnel construction. One of the most limiting factors in cucurbit production in general is the cucumber beetle complex and the bacterial pathogen they transmit. In this study, we investigated the optimal size of netting installed on high tunnels to prevent cucumber beetle colonization while maintaining ventilation to reduce heat stress. Of the three mesh sizes investigated across 4 yr, the intermediate mesh with a pore size of 0.72 × 0.97 mm was optimal to exclude cucumber beetles, maintain ventilation, and produce the highest yields for both cucumber and melon plants. The smallest (0.16 mm2) and intermediate mesh sizes resulted in secondary pest outbreaks (e.g., aphids), which did not occur in open tunnels and to a lesser extent in tunnels covered with the largest (1.00 × 4.00 mm) mesh. Despite these secondary pests, yield was higher in small- and intermediate-sized mesh treatments due to relief from cucumber beetle infestations, including striped (Acalymma vittatum Fabr. (Coleoptera: Chrysomelidae)) and spotted (Diabrotica undecimpunctata howardi Barber (Coleoptera: Chrysomelidae)) beetles. Overall, we conclude that insect exclusion netting is an effective method to exclude cucumber beetles from high tunnels, but mesh size should be carefully considered when weighing the collective effects on yield and primary/secondary pest abundance.
The Efficacy of Ethnic Stacking: Military Defection during Uprisings in Africa
Authors: Morency-Laflamme Julien , McLauchlin Theodore 
Published: February 2019

AbstractDoes ethnic stacking in the armed forces help prevent military defection? Recent research, particularly in Africa and the Middle East, suggests so; by favoring in-groups, regimes can keep in-group soldiers loyal. In-group loyalty comes at the cost of antagonizing members of out-groups, but many regimes gladly run that risk. In this research note, we provide the first large-scale evidence on the impact of ethnic stacking on the incidence of military defection during uprisings from below, using data on fifty-seven popular uprisings in Africa since formal independence. We find clear evidence for the downside: ethnic stacking is associated with more frequent defection if out-group members are still dominant in the armed forces. We find more limited support for the hypothesized payoff. Ethnic stacking may reduce the risk of defection, but only in regimes without a recent history of coup attempts. Future research should therefore trace the solidification of ethnic stacking over time.
Evaluation and Management of Congenital Chagas Disease in the United States
Authors: Edwards Morven S , Stimpert Kelly K , Bialek Stephanie R , Montgomery Susan P 
Published: February 2019

AbstractChagas disease is underappreciated as a health concern in the United States. Approximately 40 000 women of childbearing age living in the United States have chronic Chagas disease. Most of them are unaware that they have an infection that is transmissible to their offspring. The estimated US maternal-to-infant transmission rate of Trypanosoma cruzi is 1% to 5%. Ten percent to 40% of neonates with congenital T cruzi infection have clinical signs consistent with a congenital infection but no findings are unique to Chagas disease. If left untreated, 20% to 40% of infants with Chagas disease will later develop potentially fatal cardiac manifestations. Molecular testing can confirm the diagnosis in neonates. Treatment is well tolerated in infancy and usually results in cure. Screening of at-risk women during pregnancy can identify maternal infection and allow early assessment and treatment for congenital T cruzi infection.
Transcribear – Introducing a secure online transcription and annotation tool
Authors: Chen Yu-Hua , Bruncak Radovan 
Published: February 2019

Abstract
Reliable high-quality transcription and/or annotation (a.k.a. ‘coding’) is essential for research in a variety of areas in Humanities and Social Sciences which make use of qualitative data such as interviews, focus groups, classroom observations, or any other audio/video recordings. A good tool can facilitate the work of transcription and annotation because the process is notoriously time-consuming and challenging. However, our survey indicates that few existing tools can accommodate the requirements for transcription and annotation (e.g. audio/video playback, spelling checks, keyboard shortcuts, adding tags of annotation) in one place so that a user does not need to constantly switch between multiple windows, for example, an audio player and a text editor. ‘Transcribear’ (https://transcribear.com) is therefore developed as an easy-to-use online tool which facilitates transcription and annotation on the same interface while this web tool operates offline so that a user’s recordings and transcripts can remain secure and confidential. To minimize human errors, the functionality of tag validation is also added. Originally designed for a multimodal corpus project UNNC CAWSE (https://www.nottingham.edu.cn/en/english/research/cawse/), this browser-based application can be customized for individual users’ needs in terms of the annotation scheme and corresponding shortcut keys. This article will explain how this new tool can make tedious and repetitive manual work faster and easier and at the same time improve the quality of outputs as the process of transcription and annotation tends to be prone to human errors. The limitations of Transcribear and future work will also be discussed.
Hydrocephalus
Authors: Clark Robin D. , Curry Cynthia J. 
Published: February 2019

Abstract
This chapter reviews background information about the incidence, risk factors, sex ratio, genetics, recurrence risk, and epidemiology of isolated and syndromic hydrocephalus. Extrinsic causes of hydrocephalus are discussed including prematurity, hemorrhage, maternal Vitamin K deficiency. The discussion on the differential diagnosis of hydrocephalus summarizes its common causes, including teratogenic agents (LCMV, TORCH, parvovirus and other viral infections, isotretinoin, misoprostol), chromosome anomalies (trisomy 9, triploidy, copy number variants), and Mendelian disorder in which hydrocephaly occurs with other CNS anomalies or associated with malformations in other organ systems. The chapter offers recommendations for evaluation and management. A clinical case presentation features an infant with hydrocephalus, ectopic calcifications, a rash and consumptive thrombopenia caused by neonatal-onset multisystem inflammatory disorder.
Descriptive Analysis of Cardiac Patients Transported by Critical Care Air Transport Teams
Authors: Savell Shelia C , Arana Allyson A , Medellin Kimberly L , Bebarta Vikhyat S , Perez Crystal A , Reeves Lauren K , Mora Alejandra G , Maddry Joseph K 
Published: February 2019

Abstract

Introduction
Critical Care Air Transport Teams (CCATTs) transport critically ill patients within and out of theaters of combat operations. Studies of the CCATT population reveal as many as 35% of patients have a non-trauma diagnosis, of which more than half are cardiac.
The purpose of this retrospective study was to describe the epidemiology of critically ill patients with cardiac diagnoses evacuated from theater via CCATT.

Materials and Methods
We conducted a retrospective review of 290 medical patients with a primary cardiac diagnosis transported from any theater of operation to Landstuhl Regional Medical Center, Germany from January 2007 to April 2015.

Results
The majority of patients were male with an average age of 46 ± 11 years, US contractors (47%, n = 137), followed by US Active Duty (32%, n = 93). Patients had an average BMI of 29 ± 5; 62% of cardiac patients were either overweight or obese. The most common cardiac diagnoses were ST elevation myocardial infarction, Non-ST elevation myocardial infarction, and angina. Pre-flight vital signs indicate overall patients were stable prior to evacuation, with the majority receiving supplemental oxygen and only 5% requiring mechanical ventilation. Eighty-one percent of patients experienced at least one cardiac event during flight, however less than 5% required adjustment to oxygen or ventilator settings.

Conclusions
Critically ill cardiac patients make up a significant portion of patients transported out of the combat theater. These patients are older, overweight and have identified risk factors for cardiac morbidity. More strenuous pre-deployment screening for risk factors and prevention strategies could minimize the use of military resources to evacuate these patients from the combat theater.
N-Acetylcysteine (NAC) for the Prevention of Liver Failure in Heat Injury-Mediated Ischemic Hepatitis
Authors: Will Joshua S , Snyder Christopher J , Westerfield Katie L 
Published: February 2019

AbstractExertional Heat Illness with associated ischemic hepatitis (IH) is a common occurrence among military trainees; however, few specific therapies exist if unresponsive to appropriate supportive measures.A 27-year-old basic combat trainee presented with altered mental status, renal insufficiency, rhabdomyolysis, and a core temp of 107.9 °F after collapsing during a run, leading to the diagnosis of heat stroke. While the patient’s azotemia and creatinine kinase levels rapidly improved with aggressive intravenous hydration, transaminases continued to increase to nearly 155 times the upper limit of normal. Further laboratory evaluation revealed coagulopathy and thrombocytopenia suggestive of acute liver failure (ALF). On hospital day three, the patient was started on N-acetylcysteine (NAC). Evaluation for infectious and autoimmune etiologies of ALF was unremarkable; thus, the patient’s symptomatology was attributed to IH resulting from heat stroke. Liver function normalized on NAC.Heat Injury is common among US Army recruits and results in thousands of hospitalizations in recent years. IH is characterized by diffuse hepatocyte necrosis following an episode of hemodynamic instability, and is an established sequela of Heat Injury. The mortality of IH among critically ill patients has been estimated to be as high as 60%, with those demonstrating coagulopathy especially at risk. NAC is shown to improve the transplant-free survival rate in non-acetaminophen related ALF, consistent with its proposed mechanisms of improving hepatic blood flow and conjugating toxic metabolites. NAC therapy should be considered early in the course of heat injury-mediated IH to reduce reperfusion injury, improving transplant free outcomes.
Diagnostic usefulness of differential time to positivity in neutropenic cancer patients with suspected catheter-related candidemia
Authors: Jo Kyeong Min , Choi Sungim , Jung Kyung Hwa , Park Jung Wan , Yun Ji Hyun , Kim Min Jae , Chong Yong Pil , Lee Sang-Oh , Choi Sang-Ho , Kim Yang Soo , Woo Jun Hee , Lee Jung-Hee , Lee Je-Hwan , Lee Kyoo-Hyung , Kim Sung-Han 
Published: February 2019

Abstract
Methods for distinguishing catheter-related candidemia (CRC) from non-CRC before catheter removal remain limited. We thus evaluated the diagnostic performance of differential time to positivity (DTP) to diagnose CRC in neutropenic cancer patients with suspected CRC. Of the 35 patients enrolled, 15 (43%) with CRC (six definite and nine probable) and 17 (49%) with non-CRC were finally analyzed. Based on the receiver operating characteristic curve, the optimal cutoff value of DTP for diagnosing CRC was ≥1.45 hours with the sensitivity 80% (95% confidence interval [CI], 51–95) and specificity 100% (95% CI, 80–100), respectively.
Deblending galaxy superpositions with branched generative adversarial networks
Authors: Reiman David M , Göhre Brett E 
Published: February 2019

Abstract
Near-future large galaxy surveys will encounter blended galaxy images at a fraction of up to 50 per cent in the densest regions of the Universe. Current deblending techniques may segment the foreground galaxy while leaving missing pixel intensities in the background galaxy flux. The problem is compounded by the diffuse nature of galaxies in their outer regions, making segmentation significantly more difficult than in traditional object segmentation applications. We propose a novel branched generative adversarial network to deblend overlapping galaxies, where the two branches produce images of the two deblended galaxies. We show that generative models are a powerful engine for deblending given their innate ability to infill missing pixel values occluded by the superposition. We maintain high peak signal-to-noise ratio and structural similarity scores with respect to ground truth images upon deblending. Our model also predicts near-instantaneously, making it a natural choice for the immense quantities of data soon to be created by large surveys such as Large Synoptic Survey Telescope, Euclid, and Wide-Field Infrared Survey Telescope.
Two debatable cases for the reconstruction of the solar activity around the Maunder Minimum: Malapert and Derham
Authors: Carrasco V M S , Vaquero J M , Gallego M C , Villalba Álvarez J , Hayakawa H 
Published: February 2019

ABSTRACT
We perform case studies of the sunspot observations by Charles Malapert and William Derham from the point of view of the reconstruction of the solar activity. They made sunspot observations prior and after the deep Maunder Minimum, respectively, being two of the most active sunspot observers of their time. The currently available sunspot group data bases assign one sunspot group for most of observations by Malapert and Derham. However, with documental evidence, we attest that these observers would have sometimes recorded several sunspot groups as only one representative group. Therefore, we conclude that their sunspot group counting should be used with caution for the reconstruction of the solar activity level around the Maunder Minimum.
A new diagnostic to separate line emission from star formation, shocks, and AGNs simultaneously in IFU data
Authors: D'Agostino Joshua J , Kewley Lisa J , Groves Brent A , Medling Anne , Dopita Michael A , Thomas Adam D 
Published: February 2019

ABSTRACT
In the optical spectra of galaxies, methods for the separation of line emission arising from star formation and an additional hard component, such as shocks or active galactic nuclei (AGNs), is well-understood and possible with current diagnostics. However, such diagnostics fail when attempting to separate and define line emission which arises from shocked gas, and that arising from AGNs. We present a new three-dimensional diagnostic diagram for integral field unit data which can simultaneously separate the line emission amongst star formation, shocks, and AGNs within a galaxy. We show that regions we define as AGN-dominated correlate well with the hard X-ray distribution in our test case NGC 1068, as well as with known regions of AGN activity in NGC 1068. Similarly, spaxels defined as shock-dominated correlate strongly with regions of high-velocity dispersion within the galaxy.
Subperiosteal vs Subdural Drain After Burr-Hole Drainage of Chronic Subdural Hematoma: A Randomized Clinical Trial (cSDH-Drain-Trial)
Authors: Soleman Jehuda , Lutz Katharina , Schaedelin Sabine , Kamenova Maria , Guzman Raphael , Mariani Luigi , Fandino Javier 
Published: February 2019

Abstract

BACKGROUND
The use of a subdural drain (SDD) after burr-hole drainage of chronic subdural hematoma (cSDH) reduces recurrence at 6 mo. Subperiosteal drains (SPDs) are considered safer, since they are not positioned in direct contact to cortical structures, bridging veins, or hematoma membranes.

OBJECTIVE
To investigate whether the recurrence rate after insertion of a SPD is noninferior to the insertion of a more commonly used SDD.

METHODS
Multicenter, prospective, randomized, controlled, noninferiority trial analyzing patients undergoing burr-hole drainage for cSDH aged 18 yr and older. After hematoma evacuation, patients were randomly assigned to receive either a SDD (SDD-group) or a SPD (SPD-group). The primary endpoint was recurrence indicating a reoperation within 12 mo, with a noninferiority margin of 3.5%. Secondary outcomes included clinical and radiological outcome, morbidity and mortality rates, and length of stay.

RESULTS
Of 220 randomized patients, all were included in the final analysis (120 SPD and 100 SDD). Recurrence rate was lower in the SPD group (8.33%, 95% confidence interval [CI] 4.28-14.72) than in the SDD group (12.00%, 95% CI 6.66-19.73), with the treatment difference (3.67%, 95% CI -12.6-5.3) not meeting predefined noninferiority criteria. The SPD group showed significantly lower rates of surgical infections (P = .0406) and iatrogenic morbidity through drain placement (P = .0184). Length of stay and mortality rates were comparable in both groups.

CONCLUSION
Although the noninferiority criteria were not met, SPD insertion led to lower recurrence rates, fewer surgical infections, and lower drain misplacement rates. These findings suggest that SPD may be warranted in routine clinical practice
The Contribution of National Income Inequality to Regional Economic Divergence
Authors: Manduca Robert A 
Published: February 2019

AbstractAfter more than a century of convergence, the economic fortunes of rich and poor regions of the United States have diverged dramatically over the last 40 years. Roughly a third of the US population now lives in metropolitan areas that are substantially richer or poorer than the nation as a whole, almost three times the proportion that did in 1980. In this paper I use counterfactual simulations based on Census microdata to understand the dynamics of regional divergence. I first show that regional divergence has primarily resulted from the richest people and places pulling away from the rest of the country. I then estimate the relative contributions to regional divergence of two major socioeconomic trends of recent decades: the sorting of people across metro areas by income level and the national rise in income inequality. I show that the national rise in income inequality is sufficient on its own to account for more than half of the observed divergence across regions, while income sorting on its own accounts for less than a quarter. The major driver of regional economic divergence is national-level income dispersion that has exacerbated preexisting spatial inequalities.
Sex Modifies Acute Ozone-Mediated Airway Physiologic Responses
Authors: Birukova Anastasiya , Cyphert-Daly Jaime , Cumming Robert Ian , Yu Yen-Rei , Gowdy Kymberly M , Que Loretta G , Tighe Robert M 
Published: February 2019

Abstract
Sex differences clearly exist in incidence, susceptibility, and severity of airway disease and in pulmonary responses to air pollutants such as ozone (O3). Prior rodent O3 exposure studies demonstrate sex-related differences in the expression of lung inflammatory mediators and signaling. However, whether or not sex modifies O3-induced airway physiologic responses remains less explored. To address this, we exposed 8- to 10-week-old male and female C57BL/6 mice to either 1 or 2 ppm O3 or filtered air (FA) for 3 h. At 12, 24, 48, and 72 h following exposure, we assessed airway hyperresponsiveness to methacholine (MCh), bronchoalveolar lavage fluid cellularity, cytokines and total protein/albumin, serum progesterone, and whole lung immune cells by flow cytometry. Male mice generated consistent airway hyperresponsiveness to MCh at all time points following exposure. Alternatively, females had less consistent airway physiologic responses to MCh, which were more variable between individual experiments and did not correlate with serum progesterone levels. Bronchoalveolar lavage fluid total cells peaked at 12 h and were persistently elevated through 72 h. At 48 h, bronchoalveolar lavage cells were greater in females versus males. Bronchoalveolar lavage fluid cytokines and total protein/albumin increased following O3 exposure without sex differences. Flow cytometry of whole lung tissue identified dynamic O3-induced immune cell changes also independent of sex. Our results indicate sex differences in acute O3-induced airway physiology responses and airspace influx without significant difference in other injury and inflammation measures. This study highlights the importance of considering sex as a biological variable in acute O3-induced airway physiology responses.
Factors Associated with the Consumption of Food Markers of Unhealthy Diet Among School Children in Situations of High Health Vulnerability
Authors: Sousa Taciana Maia de , Santos Luana Caroline dos , Costa Hellena Thaís Pinto , Carvalho Renata Bicalho de , Pereira Simone Cardoso Lisboa 
Published: February 2019

AbstractCross-sectional study that aimed to investigate the factors associated with the consumption of food markers of unhealthy diet among school children with high health vulnerability in public schools of a Brazilian capital. Unhealthy food consumption was investigated through a simplified Food Frequency Questionnaire. Multivariate logistic regression was performed, considering excessive consumption of unhealthy foods as an outcome. A total of 299 students were evaluated, with a mean age of 11.0 ± 2.4 years, 54.8% female and 20.2% overweight. Excessive consumption of unhealthy foods was observed in 46.2% of the sampled population. The chance of excessive consumption of unhealthy foods was greater among school children who skip breakfast (OR = 2.80; 95% CI 1.38–6.48); and those who habitually eat in front of the screen (OR = 2.99; 95% CI 1.11–7.06). These findings can guide interventions to promote healthy habits among school children with high health vulnerability, preventing lifelong excess weight.