bluuebunny/crossref_metadata_2025_split huggingface dataset:
Splenic artery aneurysm rupture in the pregnant patient: The importance of utilising ultrasound to differentiate the acute abdomen from obstetric causes of abdominal pain
Authors: Napier Donna 
Published: July 2019

AbstractAlthough splenic artery aneurysm (SAA) rupture in the pregnant patient is considered a rare occurrence, its consequences can be catastrophic for both mother and fetus. The mortality rate from this entity in pregnancy is disproportionately high when compared with that of the general population, with multiparity thought to be a contributing factor. Potential reasons for this may be explained by its non‐specific abdominal symptoms often misdiagnosed as common obstetric differentials, combined with a rapid deterioration of patient condition post rupture. For these reasons, SAA rupture should have a high index of suspicion when a pregnant women presents with an acute abdomen, as a favourable outcome is dependent on prompt diagnosis and appropriate medical intervention. This article reviews the incidence of SAA rupture in pregnancy, outlines the pathophysiological processes that contribute to this entity being more prevalent in the gravid population, and displays the pivotal role ultrasound can play in expediting this diagnosis. In the emergency situation, ultrasound examination of a pregnant patient should be extended from a focussed pelvic study to encompass the entire abdominal cavity. Its portability combined with its nonionising nature makes ultrasound the modality of choice to reduce the time to diagnosis and thus influence treatment pathways.
Straddling the crevasse: A review of microservice software architecture foundations and recent advancements
Authors: Joseph Christina Terese , Chandrasekaran K. 
Published: July 2019

SummaryMicroservice architecture style has been gaining wide impetus in the software engineering industry. Researchers and practitioners have adopted the microservices concepts into several application domains such as the internet of things, cloud computing, service computing, and healthcare. Applications developed in alignment with the microservices principles require an underlying platform with management capabilities to coordinate the different microservice units and ensure that the application functionalities are delivered to the user. A multitude of approaches has been proposed for the various tasks in microservices‐based systems. However, since the field is relatively young, there is a need to organize the different research works. In this study, we present a comprehensive review of the research approaches directed toward microservice architectures and propose a multilevel taxonomy to categorize the existing research. The study also discusses the different distributed computing paradigms employing microservices and identifies the open research challenges in the domain.
Tcf7l1 Acts as a Suppressor for the Self-Renewal of Liver Cancer Stem Cells and Is Regulated by IGF/MEK/ERK Signaling Independent of β-Catenin
Authors: Shan Juanjuan , Shen Junjie , Wu Min , Zhou Haijun , Feng Juan , Yao Chao , Yang Zhi , Ma Qinghua , Luo Yanfeng , Wang Yuanliang , Qian Cheng 
Published: July 2019

Abstract
Tcf7l1, which is a key effector molecule of the Wnt/β-catenin signaling pathway, is highly expressed in various cancers, and it promotes tumor growth. In this study, we demonstrated that unlike its tumor-promoting effects in several other types of cancers, Tcf7l1 expression is downregulated in hepatocarcinoma compared with their adjacent nontumor counterparts. Underexpression of Tcf7l1 is correlated with poorer survival. In liver cancer stem cell (CSC) populations, Tcf7l1 expression is downregulated. Ectopic expression of Tcf7l1 attenuates the self-renewal abilities of liver CSCs. Mechanistically, Tcf7l1 regulates the self-renewal abilities of liver CSCs through transcriptional repression of the Nanog gene, and the effect is independent of β-catenin. Moreover, we found that Tcf7l1 expression is controlled by extracellular insulin-like growth factor (IGF) signaling, and we demonstrated for the first time that IGF signaling stimulates Tcf7l1 phosphorylation and degradation through the mitogen-activated protein kinase (MEK)/extracellular signal-regulated kinase (ERK) pathway. Overall, our results provide some new insights into how extracellular signals modulate the self-renewal of liver CSCs and highlight the inhibitory roles of Tcf7l1 in cancer. Stem Cells 2019;37:1389–1400
Common Physical Barriers That Limit Access for Voters with Disabilities and Options to Solve Them
Authors: Terry Jim , Dunlap Kaylan , Flickinger Steve , Woosley Dan 
Published: July 2019

AbstractSuccessfully conducting an election requires that election administrators consider the diverse needs of their constituents and provide polling locations that allow those with disabilities to access the polling location and cast a ballot without encountering barriers. Having a working knowledge of the terminology and standards used to assess polling location accessibility can ensure that election administrators and poll workers are creating an environment that allows all voters to cast a ballot.
Probing neutrino transition magnetic moments with coherent elastic neutrino-nucleus scattering
Authors: Miranda O. G. , Papoulias D. K. , Tórtola M. , Valle J. W. F. 
Published: July 2019

AbstractWe explore the potential of current and next generation of coherent elastic neutrino-nucleus scattering (CEνNS) experiments in probing neutrino electromagnetic interactions. On the basis of a thorough statistical analysis, we determine the sensitivities on each component of the Majorana neutrino transition magnetic moment (TMM), |Λi|, that follow from low-energy neutrino-nucleus experiments. We derive the sensitivity to neutrino TMM from the first CEνNS measurement by the COHERENT experiment, at the Spallation Neutron Source. We also present results for the next phases of COHERENT using HPGe, LAr and NaI[Tl] detectors and for reactor neutrino experiments such as CONUS, CONNIE, MINER, TEXONO and RED100. The role of the CP violating phases in each case is also briefly discussed. We conclude that future CEνNS experiments with low-threshold capabilities can improve current TMM limits obtained from Borexino data.
Looking for partially-massless gravity
Authors: Joung Euihun , Mkrtchyan Karapet , Poghosyan Gabriel 
Published: July 2019

AbstractWe study the possibility for a unitary theory of partially-massless (PM) spin-two field interacting with Gravity in arbitrary dimensions. We show that the gauge and parity invariant interaction of PM spin two particles requires the inclusion of specific massive spin-two fields and leads to a reconstruction of Conformal Gravity, or multiple copies of the latter in even dimensions. By relaxing the parity invariance, we find a possibility of a unitary theory in four dimensions, but this theory cannot be constructed in the standard formulation, due to the absence of the parity-odd cubic vertex therein. Finally, by relaxing the general covariance, we show that a “non-geometric” coupling between massless and PM spin-two fields may lead to an alternative possibility of a unitary theory. We also clarify some aspects of interactions between massless, partially-massless and massive fields, and resolve disagreements in the literature.
Frictionless Contact Problem for a Functionally Graded Layer Loaded Through Two Rigid Punches Using Finite Element Method
Authors: Polat A. , Kaya Y. , Bendine K. , Özşahin T.Ş. 
Published: July 2019

ABSTRACTIn this study, continuous contact problem in the functionally graded (FG) layer loaded with two rigid flat blocks resting on the elastic semi-infinite plane was analyzed by the finite element method. The two-dimensional numerical model of the FG layer was made with the software added to the ANSYS program. This software can be adapted to all contact problem types by making minor changes. The accuracy check of the program was performed by comparing with the analytical solution of the problem by homogeneous layer and its solution by the finite element method. So, fast and practical solutions can be obtained by the developed finite element method on many applications such as; automotive, aviation and space industry applications. The comparisons made showed that the proposed solution gave good results at acceptable levels. In the problem, it was thought that all surfaces were frictionless. The external loads P and Q were transmitted to the FG layer via two flat rigid blocks. Normal stresses between the FG layer and the elastic plane, initial separation loads, initial separation distances and contact stresses under the blocks were investigated for various dimensionless quantities.
Distributions as initial values in a triangular hyperbolic system of conservation laws
Authors: Sarrico C. O. R. , Paiva A. 
Published: July 2019

AbstractThe present paper concerns the systemut + [ϕ(u)]x = 0,vt + [ψ(u)v]x = 0 having distributions as initial conditions. Under certain conditions, and supposingϕ,ψ: ℝ → ℝ functions, we explicitly solve this Cauchy problem within a convenient space of distributionsu,v. For this purpose, a consistent extension of the classical solution concept defined in the setting of a distributional product (not constructed by approximation processes) is used. Shock waves,δ-shock waves, and also waves defined by distributions that are not measures are presented explicitly as examples. This study is carried out without assuming classical results about conservation laws. For reader's convenience, a brief survey of the distributional product is also included.
The Smithian–Spathian boundary in North Greenland: implications for extreme global climate changes
Authors: Lindström Sofie , Bjerager Morten , Alsen Peter , Sanei Hamed , Bojesen-Koefoed Jørgen 
Published: July 2019

AbstractSmithian–lower Anisian strata in Peary Land, North Greenland, were deposited at ∼45° N on the northern margin of Pangaea in offshore to upper shoreface settings. The well-constrained succession (palynology and ammonite biostratigraphy) documents a remarkable shift from lycophyte spore-dominated assemblages in the upper Smithian to gymnosperm pollen-dominated ones in the lower Spathian in concert with a marked shift of +6 ‰ in δ13Corg. Correlation with other Smithian–Spathian boundary sections that record terrestrial floral changes indicates that the recovery of gymnosperms began earlier in the mid-latitudes of the Southern Hemisphere than in the Northern Hemisphere. The lycophyte-dominated Late Smithian Thermal Maximum is here interpreted as reflecting dry and hot climatic conditions with only brief seasonal precipitation unable to sustain large areas of gymnosperm trees, but able to revive dehydrated lycophytes. This suggests that the Late Smithian Thermal Maximum was a time of widespread aridity, which is also supported by red bed deposition in many areas globally, even as far south as Antarctica. The shift to gymnosperm-dominated vegetation during the cooling across the Smithian–Spathian boundary reflects a change to seasonally more humid climatic conditions favouring gymnosperm recovery, and could have been initiated by increased albedo over land due to the widespread aridity during the Late Smithian Thermal Maximum. The recovery of gymnosperm vegetation would have helped to draw down CO2from the atmosphere and exacerbate global cooling.
Effects of large-scale oceanic phenomena on non-cholera vibriosis incidence in the United States: implications for climate change
Authors: Logar-Henderson Chloë , Ling Rebecca , Tuite Ashleigh R. , Fisman David N. 
Published: July 2019

Abstract
Non-cholera Vibrio (NCV) species are important causes of disease. These pathogens are thermophilic and climate change could increase the risk of NCV infection. The El Niño Southern Oscillation (ENSO) is a ‘natural experiment’ that may presage ocean warming effects on disease incidence. In order to evaluate possible climatic contributions to observed increases in NCV infection, we obtained NCV case counts for the United States from publicly available surveillance data. Trends and impacts of large-scale oceanic phenomena, including ENSO, were evaluated using negative binomial and distributed non-linear lag models (DNLM). Associations between latitude and changing risk were evaluated with meta-regression. Trend models demonstrated expected seasonality (P < 0.001) and a 7% (6.1%–8.1%) annual increase in incidence from 1999 to 2014. DNLM demonstrated increased vibriosis risk following ENSO conditions over the subsequent 12 months (relative risk 1.940, 95% confidence interval (CI) 1.298–2.901). The ‘relative–relative risk’ (RRR) of annual disease incidence increased with latitude (RRR per 10° increase 1.066, 95% CI 1.027–1.107). We conclude that NCV risk in the United States is impacted by ocean warming, which is likely to intensify with climate change, increasing NCV risk in vulnerable populations.
Crash Telemetry-Based Injury Severity Prediction is Equivalent to or Out-Performs Field Protocols in Triage of Planar Vehicle Collisions
Authors: He Katherine , Zhang Peng , Wang Stewart C. 
Published: July 2019

AbstractIntroduction:With the increasing availability of vehicle telemetry technology, there is great potential for Advanced Automatic Collision Notification (AACN) systems to improve trauma outcomes by detecting patients at-risk for severe injury and facilitating early transport to trauma centers.Methods:National Automotive Sampling System Crashworthiness Data System (NASS-CDS) data from 1999-2013 were used to construct a logistic regression model (injury severity prediction [ISP] model) predicting the probability that one or more occupants in planar, non-rollover motor vehicle collisions (MVCs) would have Injury Severity Score (ISS) 15+ injuries. Variables included principal direction of force (PDOF), change in velocity (Delta-V), multiple impacts, presence of any older occupant (≥55 years old), presence of any female occupant, presence of right-sided passenger, belt use, and vehicle type. The model was validated using medical records and 2008-2011 crash data from AACN-enabled Michigan (USA) vehicles identified from OnStar (OnStar Corporation; General Motors; Detroit, Michigan USA) records. To compare the ISP to previously established protocols, a literature search was performed to determine the sensitivity and specificity of first responder identification of ISS 15+ for MVC occupants.Results:The study population included 924 occupants in 836 crash events. The ISP model had a sensitivity of 72.7% (95% Confidence Interval [CI] 41%-91%) and specificity of 93% (95% CI 92%-95%) for identifying ISS 15+ occupants injured in planar MVCs. The current standard 2006 Field Triage Decision Scheme (FTDS) was 56%-66% sensitive and 75%-88% specific in identifying ISS 15+ patients.Conclusions:The ISP algorithm comparably is more sensitive and more specific than current field triage in identifying MVC patients at-risk for ISS 15+ injuries. This real-world field study shows telemetry data transmitted before dispatch of emergency medical systems can be helpful to quickly identify patients who require urgent transfer to trauma centers.
Automatic matching using intraprostatic calcifications as a volume of interest in CBCT images during prostate radiotherapy: a comparative study
Authors: O’Connor P. , Barker K. 
Published: July 2019

AbstractAim:The study aimed to assess the clinical feasibility of employing an automatic match during cone beam computed tomography (CBCT) imaging using prostatic calcifications within the 95% isodose set as the region of interest.Materials and methods:CBCT images were analysed on the 5th fraction in 34 patients evaluating the difference between standard manual soft tissue anatomy matching versus auto calcification matching. An assessment of the clinical feasibility of using prostatic calcifications during matching alongside considering the effect a more automated matching process has been conducted on interobserver variability.Results:The standard deviation values of the difference between the soft tissue match (baseline) versus automatic calcification matches fluctuated around 1 mm in all three axes for all of the matches carried out. The interobserver variability observed between the two radiographers was 0·055, 0·065 and 0·045 cm in the vertical, longitudinal and lateral axes, respectively.Findings:The clarity of the calcifications on the CBCT images might explain the low interobserver variability displayed by the two matching radiographers. A calcification provides a clear starting point for image matching before commencing a check of volumetric coverage, if the matching process begins in the same place, it can allow for a standardisation of matching technique between radiographers.
Tracing Chinese Scholar Chen Tiqiang's Pursuit of International Law Education and His Major Contribution to the Doctrine of Recognition
Authors: CHEN Li 
Published: July 2019

AbstractThis paper relies on archival research to rediscover Chen Tiqiang's study of public international law at Tsinghua University and Oxford University with James Brierly. Particular attention is directed to Brierly's profound influence on Chen's approach to researching the doctrine of recognition and his remarkable performance at his oral examination before Humphrey Waldock and Robert Y. Jennings. In addition to providing an abbreviated overview of the international legal community's overwhelmingly favourable reactions to the publication of Chen's dissertation in 1951, it argues that Chen's experience and accomplishments provide some evidence that China's teaching and scholarship of international law attained an unprecedented milestone in the late 1930s and 1940s.
Extreme Water Levels for Australian Beaches Using Empirical Equations for Shoreline Wave Setup
Authors: O'Grady J. G. , McInnes K. L. , Hemer M. A. , Hoeke R. K. , Stephenson A. G. , Colberg F. 
Published: July 2019

AbstractEmpirical equations for wave breaking and wave setup are compared with archived shoreline wave setup measurements to investigate the contribution of wind waves to extreme Mean Total Water Levels (MTWL, the mean height of the shoreline), for natural beaches exposed to open ocean wind waves. A broad range of formulations is compared through linear regression and quantile regression analysis of the highest measured values. Shoreline wave setup equations are selected based on the availability of local beach slope data and the ability of the quantile regression to show a good representation of the highest measured levels. Wave parameters from an existing spectral wave hindcast are used as input to the selected equations and are combined with a storm tide time series to quantify the relative contribution of shoreline wave setup to the extreme MTWL climate along Australian beaches. A multipass analysis is provided to understand the ability to capture the shoreline wave setup estimates with and without considering beach slope. The national scale analysis which does not include beach slope indicates there are multiple contributing factors to MTWL. Examples are provided at two locations of differing local beach slope to show the importance of including local beach slope in determining the contribution of waves to MTWL. A tool is in development for further investigation of wave setup for Australian beaches.
Nonseismic Signals in the Ocean: Indicators of Deep Sea and Seafloor Processes on Ocean‐Bottom Seismometer Data
Authors: Batsi Evangelia , Tsang‐Hin‐Sun Eve , Klingelhoefer Frauke , Bayrakci Gaye , Chang Emmy T.Y. , Lin Jing‐Yi , Dellong David , Monteil Clément , Géli Louis 
Published: July 2019

AbstractOcean‐bottom seismometers (OBSs) commonly record short‐duration events (SDEs) that could be described by all of these characteristics: (i) duration <1 s, (ii) one single‐wave train with no identified P nor S wave arrivals, and (iii) a dominant frequency usually between 4 and 30 Hz. In many areas, SDEs have been associated with gas‐ or fluid‐related processes near cold seeps or hydrothermal vents, although fish bumps, instrumental, or current‐generated noise have been proposed as possible sources. In order to address some remaining issues, this study presents results from in situ and laboratory experiments combined with observations from two contrasting areas, the Sea of Marmara (Turkey) and the Chilean subduction zone. The in situ experiment was conducted at the European Multidisciplinary Seafloor and water column Observatory‐Molène submarine observatory (near Brest, France) and consisted in continuously monitoring two OBSs with a camera. The images revealed that no fish regularly bumped into the instruments. Laboratory experiments aimed at reproducing SDEs' waveforms by injecting air or water in a tank filled by sand and seawater and monitored with an OBS. Injecting air in the sediments produced waveforms very similar to the observed SDEs, while injecting air in the water column did not, constraining the source of SDEs in the seafloor sediments. Finally, the systematic analysis of two real data sets revealed that it is possible to discriminate gas‐related SDEs from biological or sea state‐related noise from simple source parameters, such as the temporal mode of occurrence, the back azimuth, and the dominant frequency.
Changes of Slip Rate and Slip‐Plane Orientation by Fault Geometrical Complexities During Fluid Injection
Authors: Zhang Xi , Wu Bisheng , Jeffrey Robert G. , Yang Diansen , Chen Weizhong , Zhang Fengshou 
Published: July 2019

AbstractThe injection‐induced slip of a fault containing along‐the‐fault geometrical complexities such as permeable cracks, dilational jogs and branches, was studied numerically using a plane‐strain hydraulic fracture model. The fault is modeled by placing complexities evenly spaced on either side of the inlet where fluid coming from a steady source is injected at a constant rate. The fault slip obeys the Coulomb friction law with slip weakening of the coefficient of friction. The applied shear stress is less than the residual fault strength, corresponding to a situation where a fault undergoes stable slip behind a slowly advancing rupture front. The numerical results show that the segments of complexity may not only delay slip zone extension and fluid flow, but temporarily increase slip rates. Short‐term faster slip rates occur after cracks and jogs are pressurized. The slip rate can reach values typical of microearthquake events, accompanied by rising and then dropping pressure and producing a stress release. Especially, the discontinuous slip sources are separated by the right‐angle jogs that do not slip. The slip on branches can be activated by fluid invasion and an associated normal effective stress reduction, and the slow slip sources eventually move from the fault to the branches. Even if a hydraulic fracturing treatment presents a low risk of generating dynamic slip, when fractures intersect faults containing geometrical complexities, fast slip events may be induced. The spatiotemporally varying slip rates and patterns presented provide an alternative interpretation for recorded seismic slip signals.
Two types of functionally distinct Ca2+ stores in hippocampal neurons
Authors: Chen-Engerer Hsing-Jung , Hartmann Jana , Karl Rosa Maria , Yang Jun , Feske Stefan , Konnerth Arthur 
Published: July 2019

AbstractIt is widely assumed that inositol trisphosphate (IP3) and ryanodine (Ry) receptors share the same Ca2+ pool in central mammalian neurons. We now demonstrate that in hippocampal CA1 pyramidal neurons IP3- and Ry-receptors are associated with two functionally distinct intracellular Ca2+ stores, respectively. While the IP3-sensitive Ca2+ store refilling requires Orai2 channels, Ry-sensitive Ca2+ store refilling involves voltage-gated Ca2+ channels (VGCCs). Our findings have direct implications for the understanding of function and plasticity in these central mammalian neurons.