bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of climate change on the future quality of surface waters: case study of the Ardak River, northeast of Iran
Authors: Nikakhtar Morteza , Rahmati Seyedeh Hoda , Bavani Ali Reza Massah 
Published: February 2019

Abstract
In recent decades, climate change has influenced the quantity and quality of water resources, affecting water supply for various demands. In this case study, the effects of climate change on the quality of the Ardak River in the northeast of Iran are discussed. The Qual2kW model was used to simulate water quality parameters, by sampling dissolved oxygen (DO), pH, chemical oxygen demand (COD), and NO3. The rainfall-streamflow model IHACRES was used for simulating monthly streamflow. Monthly general circulation model (GCM) temperature and rainfall data from representative concentration pathways (RCP) RCP2.6 and RCP8.5 were downloaded for 1986 to 2005 and 2020 to 2039. The previously verified model LARS-WG was used to predict future temperatures and rainfall. By importing this data into IHACRES, stream flows were simulated, enabling Qual2kW to predict future effects on water quality. Although changes in temperature of 0.5 to 1.2 °C were predicted, maximum changes in temperature and rainfall will occur in winter and summer in series. Therefore, water quality was predicted to decrease only on the Abghad branch, due to increased temperature and lower flow rates. The highest percentage variations in DO and NO3 are −12.19 and 31.25 in RCP8.5 and in COD and PH, −35.4 and 0.29 in RCP2.6.
Development and present situation of hydropower in China
Authors: Sun Xingsong , Wang Xiaogang , Liu Lipeng , Fu Ruizhi 
Published: February 2019

Abstract
As a clean and renewable energy, hydropower holds an important place in energy development for every country. China has the richest hydropower resources with 541 GW technical exportable installed capacity, a 17% global share. Hydropower is a key point of energy conservation and comprehensive utilization of resources to ensure the sustainable development strategy of China. This paper investigates the hydropower development of China and provides a summary of the current situation of the development. Over the past 100 years, China's hydropower developed tremendously. The total installed capacity of hydropower is 341.19 GW by the end of 2017 and the installed capacity of small hydropower is 79.27 GW. By the end of June 2018, 33 pumped-storage power stations had been constructed and 32 are under construction. The total installed capacity of pumped-storage power is 72.64 GW. More development will be achieved in the next decades according to China's development strategy.
Phyllomyias griseocapilla Sclater, 1862 (piolhinhoserrano) (Aves, Tyrannidae): novas informações sobre a sua nidificação
Authors: Legal Evair 
Published: February 2019

Phyllomyias griseocapilla (piolhinho-serrano) é uma ave quase ameaçadaglobalmente, endêmica do Brasil e da floresta atlântica. Assim como os demais aspectos de sua biologia reprodutiva, poucas informações estão disponíveis sobre seu ninho. No presente estudo, são apresentadas observações sobre um ninho da espécie, encontrado no município de Botuverá, Santa Catarina (27º11’31”S e 49°02’44”O, 75 m a.n.m.), com formato fechado / retorta /pendente alongado, características diferentes dos demais ninhos previamente descritos.
Clinicopathological and Imaging Features Predictive of Clinical Outcome in Metaplastic Breast Cancer
Authors: Yoon Ga Young , Cha Joo Hee , Kim Hak Hee , Shin Hee Jung , Chae Eun Young , Choi Woo Jung , Oh Ha-Yeun 
Published: February 2019

Background:
Metaplastic breast cancer (MC) is a rare disease, thus it is difficult to
study its clinical outcomes.

Objective:
To investigate whether any clinicopathological or imaging features were associated
with clinical outcome in MC.

Methods:
We retrospectively evaluated the clinicopathological and imaging findings, and the clinical
outcomes of seventy-two pathologically confirmed MCs. We then compared these parameters
between triple-negative (TNMC) and non-TNMCs (NTNMC).

Results:
Oval or round shape, and not-circumscribed margin were the most common findings on
mammography, ultrasound (US), and magnetic resonance imaging (MRI). It was mostly a mass
without calcification on mammography, and revealed complex or hypoechoic echotexture, and posterior
acoustic enhancement on US, and rim enhancement, wash-out kinetics, peritumoral edema,
and intratumoral necrosis on MRI. Of all 72, 64 were TNMCs, and eight were NTNMCs. Clinicopathological
and imaging findings were similar between the two groups, except that MRI showed
peritumoral edema more frequently in TNMCs than NTNMCs (p=0.045). There were 21 recurrences
and 13 deaths. Multivariable analysis showed that larger tumor size and co-existing DCIS
were significantly predictive of Disease free survival (DFS), and larger tumor size and neoadjuvant
chemotherapy were significantly predictive of overall survival (OS).

Conclusion:
MC showed characteristic imaging findings, and some variables associated with survival
outcome may help to predict prognosis.
Hypoglycemic Effect of Calendula arvensis Flowers is Mediated by Digestive Enzyme Inhibition
Authors: Abudunia Abdul-Malik , Marmouzi Ilias , Kharbach Mourad , Jemli Meryem El , Sayah Karima , Bouyahya Abdelhakim , Al-kaf Ali , Alyahawi Ali , Ansar M’Hammed , Bouklouze Abdelaziz , Faouzi My El Abbes , Ibrahimi Azeddine 
Published: February 2019

Background:
Calendula arvensis is an annual Mediterranean plant growing in Morocco between
Rabat and Khemissat. C. arvensisis is known in folk medicine as an anti-inflammatory and antipyretic
remedy. However, few reports have investigated its pharmacological properties.

Methods:
The objective of the present study was to determine chemical composition of C. arvensis
flowers, and to investigate their antidiabetic activities by mean of digestive enzyme inhibition. The profile
of phenolic compounds was established by HPLC-DAD-QTOF-MS analysis. While the antidiabetic
activity was evaluated by the in vitro enzyme inhibition assays.

Results:
Phytochemical analysis revealed the presence of anthocyanins, flavonoids, tannins, and saponins
as major elements. Whereas, alkaloids and terpenes were not detected in the plant samples. The
chromatographic quantification identified 18 metabolites, with the caffeic acid as a major element. C.
arvensis aqueous and methanolic extracts exhibited higher inhibitory potential against α-amylase, α-
glucosidase and ß-galactosidase compared to the hexanic extract.

Conclusion:
The present study brings evidence to the hypoglycemic effect of C. arvensis flowers
through enzyme inhibitory activities, and identifies the possible phenolic compounds associated with
this activity.
Anti-Inflammation and Antimicrobial Constituents from the Roots and Their Production in Callus Cultures of Valeriana jatamansi Jones
Authors: Singh Bharat , Sahu Pooran M. , Sharma Ram A. 
Published: February 2019

Background:
Valeriana jatamansi Jones (Syn. V. wallichii DC.; Fam. – Valerianaceae) is a
medicinal plant species, endemic to the Himalayan regions of India and rich in presence of iridoids. This
plant species possessed antimicrobial, antioxidant and anti-inflammatory properties.

Methods:
The shade-dried roots were powdered, percolated with 95% ethanol for 36 h at room temperature
(3-times) and filtrate used for isolation of iridoids. The isolated compounds identified based on
physical and spectral data analysis. For the enhancement of production of iridoids, the callus cultures
established on Murashige and Skoog (MS) culture medium with variable concentrations of growth hormones.
The isolated iridoids estimated by using High Performance Liquid Chromatography (HPLCSPD-
M10A photodiode array detector) and Gas Chromatography–Mass Spectrometry (GC-MS) analysis.
The anti-inflammatory activity of iridoids assessed by using carrageenan and Complete Freund's
Adjuvant (CFA-induced adjuvant) models in experimental rats. The total eight bacterial and five fungal
strains used for determination of antimicrobial activity. The activity assessed by using microdilution
method.

Results:
Total seven iridoids were isolated from ethyl acetate fraction and their production estimated in
cell cultures. The maximum accumulation (69.39±0.45 mg/g) of jatamanvaltrate S was observed in 2, 4-
D (4.0 mg/l) and kinetin (1.0 mg/l) supplemented MS culture medium. Maximum anti-inflammatory
activity demonstrated by jatamanvaltrate R (46.8%) at the dose of 20 mg/kg body weight (bw) at 8 h
after carrageenan injection. Similarly, the jatamanvaltrate R also displayed maximum inhibitory activity
(49.9%) to CFA-induced adjuvant arthritis in rats on day 8. The strongest antibacterial activity was exhibited
by jatamanvaltrate S (21 μg/ml) against Staphylococcus aureus while maximum antifungal efficacy
displayed by jatamanin B (30 μg/ml) against Penicillium chrysogenum.

Conclusion:
In this study, all the isolated iridoids found as bioactive molecules and exhibited promising
anti-inflammatory and antimicrobial activities.
Enasidenib: First Mutant IDH2 Inhibitor for the Treatment of Refractory and Relapsed Acute Myeloid Leukemia
Authors: Dogra Raghav , Bhatia Rohit , Shankar Ravi , Bansal Parveen , Rawal Ravindra K. 
Published: February 2019

Background:
Acute myeloid leukemia is the collective name for different types of leukemias of
myeloid origin affecting blood and bone marrow. The overproduction of immature myeloblasts (white blood
cells) is the characteristic feature of AML, thus flooding the bone marrow and reducing its capacity to produce
normal blood cells. USFDA on August 1, 2017, approved a drug named Enasidenib formerly known as AG-221
which is being marketed under the name Idhifa to treat R/R AML with IDH2 mutation. The present review
depicts the broad profile of enasidenib including various aspects of chemistry, preclinical, clinical studies,
pharmacokinetics, mode of action and toxicity studies.

Methods:
Various reports and research articles have been referred to summarize different aspects related to
chemistry and pharmacokinetics of enasidenib. Clinical data was collected from various recently published
clinical reports including clinical trial outcomes.

Result:
The various findings of enasidenib revealed that it has been designed to allosterically inhibit mutated
IDH2 to treat R/R AML patients. It has also presented good safety and efficacy profile along with 9.3 months
overall survival rates of patients in which disease has relapsed. The drug is still under study either in combination
or solely to treat hematological malignancies. Molecular modeling studies revealed that enasidenib binds to
its target through hydrophobic interaction and hydrogen bonding inside the binding pocket. Enasidenib is found
to be associated with certain adverse effects like elevated bilirubin level, diarrhea, differentiation syndrome,
decreased potassium and calcium levels, etc.

Conclusion:
Enasidenib or AG-221was introduced by FDA as an anticancer agent which was developed as a
first in class, a selective allosteric inhibitor of the tumor target i.e. IDH2 for Relapsed or Refractory AML. Phase
1/2 clinical trial of Enasidenib resulted in the overall survival rate of 40.3% with CR of 19.3%. Phase III trial on
the Enasidenib is still under process along with another trial to test its potency against other cell lines.
Edasidenib is associated with certain adverse effects, which can be reduced by investigators by designing its
newer derivatives on the basis of SAR studies. Hence, it may come in the light as a potent lead entity for anticancer
treatment in the coming years.
Microwave-assisted Efficient One-pot Synthesis of Nitriles Using Recyclable Magnetite (Fe3O4) Nanoparticles as Catalyst and Water as Solvent: A Greener Approach
Authors: Chavan Prashant , Pednekar Suhas , Chaughule Ramesh , Lokur Anushree 
Published: February 2019

Background:
There has been an increasing curiosity over the past few years to carry out organic
reactions over heterogeneous nanocatalysts. Microwave activation coupled with a nanocatalyst along
with water as a reaction medium makes the process further green. Microwave activation as a green process
reduces reaction times, enhances product purity and improves chemical yield.

Methods:
Nitrile group chemistry has been explored by many researchers across the globe owing to its
interesting properties and its importance in synthetic chemistry. Despite several methods being available
for the synthesis of nitriles, microwave assisted synthesis of nitriles using Fe3O4 nanoparticles appears
more promising. The present study is intended at developing a recyclable magnetite (Fe3O4) nanoparticles
catalyzed protocol towards the synthesis of organonitrile derivatives using one pot reaction.

Results:
The above protocol incorporates the use of microwave for heating and water as reaction medium.
Several substituted nitriles could be synthesized for excellent yields. The magnetite nanoparticles can be
reused for new reaction without significant loss in activity.

Conclusion:
The experiment makes the protocol simple, environment friendly and economically feasible.
A tecnologia como aporte para o acesso a educação de pessoas com deficiência
Authors: Candido Eliane Aparecida Piza , Carneiro Relma Urel Carbone 
Published: February 2019

RESUMO Pretende-se através dessa pesquisa abordar a importância da tecnologia no contexto educacional, que visa à inclusão dos alunos com deficiência, abordando aspectos teóricos sobre sua utilização e ressaltando sua relevância para a construção do conhecimento, tendo como agentes desse processo o professor e o aluno. Para tanto, recorreu-se a revisão bibliográfica sobre o tema com base em material existente na literatura específica para elucidar os conceitos de inovação e tecnologia e suas formas de utilização na escola para alunos com e sem deficiência. Diante dos estudos, idealiza-se a reflexão dos docentes e demais integrantes da comunidade escolar, que baseados na tecnologia atual possam contar com apoio de recursos para inserir o indivíduo com deficiência com autonomia para uma vida em sociedade. PALAVRAS-CHAVE: Tecnologia Assistiva. Educação Especial. Inovação. ABSTRACT The objective of the following paper is to address the importance of using technology in education by teachers and students aiming the inclusion of students with disabilities, approaching theoretical aspects in its use and highlighting its relevance to knowledge construction. To do so, the authors resorted to a bibliographical review on the subject based on specific literature material to elucidate the concepts of innovation and technology and how they are used with students with or without disabilities. Thus, it displays the reflection of teachers and other educational professionals who, based on current technology, can count on the support of resources to give disabled people autonomy to live in society. KEYWORDS: Assistive Technology. Special education. Innovation. RESUMEN Se pretende por medio de esa investigación abordar la importancia de la tecnología en el contexto educativo, que visa a la inclusión de los alumnos con deficiencia, abordando aspectos teóricos sobre su utilización y resaltando su relevancia para la construcción del conocimiento, teniendo como agentes de ese proceso el profesor y el alumno. Para tanto, se ha recurrido a la revisión bibliográfica sobre el tema con base en el material existente en la literatura específica para elucidar los conceptos de innovación y tecnología y sus formas de utilización en la escuela para alumnos con y sin deficiencia. Delante de los estudios, se idealiza la reflexión de los docentes y los demás integrantes de la comunidad escolar, que basados en la tecnología actual puedan contar con apoyo de recursos para inserir el individuo con deficiencia con autonomía para una vida en sociedad. PALABRAS-CLAVE: Tecnología Assistiva. Educación Especial. Innovación. DOI: http://dx.doi.org/10.22169/revint.v13i29.1350
Iván Jaksic y Juan Luis Ossa [eds.]. Historia política de Chile, 1810-2010. Tomo I, Prácticas políticas. Santiago: Fondo de Cultura Económica Chile S.A., 2017. 506 pp.
Authors: Gaona Poveda Juan Carlos 
Published: February 2019

Reseña crítica del libro Historia política de Chile, 1810-2010. Tomo I, Prácticas políticas, Santiago, Fondo de Cultura Económica Chile S.A., 2017.
Estamos voando sobre uma bola de fogo: movimento, multiplicidade e realidade cotidiana
Authors: Simonini Eduardo 
Published: February 2019

O presente trabalho pretende pensar a realidade cotidiana como uma dimensão em multiplicidade que se abre ao diverso e à diferença. Para desenvolver esta questão, são problematizadas duas concepções sobre a realidade: uma que defende que esta pode ser compreendida como uma unidade totalizável em sua imobilidade, e outra que considera por realidade uma dinâmica em movimento sempre em vias de novas transformações. Na proposta de seguir esses dois modelos de realidade, este trabalho se utiliza, como um cordão de Ariadne, da ação de acompanhar alguns usos que foram feitos, nos últimos dois milênios, da imagem do Diabo. Desdobrando esses diferentes usos no conversar com as teorias de Platão, Hegel, Nietzsche, Deleuze e Guattari, este trabalho defende que as realidades cotidianas são forjadas em encontros incertos a agenciarem misturas que, devindo em multiplicidade, não se filiam a um projeto universal.
APRENDIZAGEM DE PROFESSORES DE LÍNGUA INGLESA: UM ESTUDO EM CONTEXTO DE ENSINO COLABORATIVO
Authors: De Laqua Ágatha Demarque de Laqua Demarque 
Published: February 2019

Esse artigo tem como objetivo discutir de que maneira a aprendizagem de professores de língua inglesa, em formação inicial e contínua, se desvela em textos produzidos por eles durante o processo de ensino
colaborativo. Os contextos da pesquisa foram salas de aula, tanto no espaço da formação de professores na Universidade Estadual de Londrina (UEL), quanto em espaços de 9o ano do Ensino Fundamental de uma escola pública em Londrina-Pr. As raízes teóricas desse artigo estão nas práticas colaborativas de ensino, conhecidas como Ensino colaborativo ou Coteaching (ROTH, TOBIN, ZIMMERMANN, 2002). O estudo envolve sete participantes no geral: uma professora formadora do curso de Letras Inglês e do Programa de Pós graduação em
Estudos da Linguagem (UEL); quatro licenciandos de Letras Inglês; o professor regente da rede pública de educação básica; e a professora pesquisadora. A coleta de dados foi realizada em 2017 e os instrumentos utilizados foram gravações em áudio de reuniões que tinham como objetivo planejar e refletir sobre o ensino
colaborativo de língua inglesa. Para análise de dados, utiliza-se a abordagem Análise do Discurso Crítica (FAIRCLOUGH, 2009) e as categorias de Modalidade e Avaliação sugeridas por Fairclough (2003a) para análise linguística em ADC (FAIRCLOUGH, 2003a; RAMALHO, RESENDE, 2011). O estudo também insere-se na área de Linguística Aplicada, no campo de Formação de professores e tem como unidade de análise práticas discursivas. Neste artigo, discuto como o processo de aprendizagem de professores de desvela, tanto em posicionamentos, representações e identificações analisadas em textos produzidos pelos participantes; quanto em como os discursos são articulados, reproduzidos e transformados durante o processo de ensino colaborativo.
A LEITURA DA LITERATURA NA FORMAÇÃO CONTINUADA DE PROFESSORES: uma potente linguagem para ressignificação das práticas escolares
Authors: Nascimento Ometto Cláudia Beatriz de Castro , Guedes-Pinto Ana Lúcia 
Published: February 2019

Considerando que a experiência com a leitura literária na formação de professores é constitutiva das
práticas por ela assumidas na mediação da formação do leitor literário na escola de educação básica,
investigamos os aprendizados – das professoras e das pesquisadoras – acerca dessa prática de leitura no contexto
de três cursos distintos de formação continuada: 1. no Pró-Letramento; 2. no PNAIC; 3. em um projeto de formação de professores responsáveis por Salas de Leitura das escolas da rede estadual de São Paulo. Os dados foram produzidos no período de 2006 a 2016 nos contextos das formações. A geração de dados se constitui a partir de vários registros: entrevistas realizadas com professoras que participaram de formação; audiogravação de
uma parte dos encontros realizados e também foram utilizados diários de campo das pesquisadoras. Os enunciados selecionados para esse artigo foram analisados a partir dos princípios metodológicos da análise enunciativa de Bakhtin (2002) e evidenciaram movimentos de elaboração sobre a prática de leitura literária. Depreende-se do estudo que a leitura de literatura pode ser uma potente linguagem para ressignificação das práticas docentes.
Pueblo, constitución y cambio
Authors: Ferreyra Gustavo 
Published: February 2019

El poder ciudadano constituyente puede construir una comunidad. Dicho poder reside en la participación libre de ciudadanos iguales, que sean capaces de decidir y discernir sobre los programas y elegir a la luz del día, en comicios auténticos, quienes han de ser sus representantes políticos que fundarán o cambiarán la norma suprema de la comunidad que propicia su existencia y cognición. La producción democrática de la Constitución, aunque caracteriza su naturaleza ineludible respecto de la parición jurídica, no presupone –ni mucho menos- una ciudadanía enteramente democrática en su ejercicio, aplicación o realización. La experiencia demuestra significativos actos de crueldad con los enunciados imperativos del poder constituyente originario. Por eso, el abuso de poder, bajo cualquier forma (prohibir elecciones, prohibir la protesta, anular o menguar la división de poderes, evitar el debate congresual, impedir la libertad de expresión, perseguir por vía jurisdiccional –sin fundamentos- a ciudadanos opositores, desfinanciar los partidos políticos, legislar o determinar políticas públicas por intermedio de la jurisdicción, proscripción política, etc.), supone actuaciones contra la democracia que desgarran cualquier posibilidad de edificación de la ciudadanía; en otras palabras: el negacionismo de una ciudadanía democrática. Negar el ejercicio del poder ciudadano puede constituir una verdadera catástrofe y el desguace del Estado Constitucional.
Desenvolvimento: um conceito em construção
Authors: Santos Elinaldo Leal , Braga Vitor , Santos Reginaldo Souza , Braga Alexandra Maria da Silva 
Published: February 2019

O presente trabalho faz uma reflexão sobre o processo de construção do conceito “desenvolvimento” na sociedade capitalista. Para tanto, utiliza-se da análise histórica com ênfase em quatro dimenões: econômica, política, social e ambiental. O estudo demonstra que o conceito surge na biologia, empregado como processo de evolução dos seres vivos para o alcance de suas potencialidades genéticas. Porém, incorpora-se nas teorias e práticas sociais,por meio da economia, sociologia, antropologia e da ciência política.No longo do seu percurso histórico o termo proporcinou algumas concepções diferentes de sociedade: sociedade do crescimento, sociedade do bem-estar social e a sociedade sustentável. Compreender a lógica que fundamenta essas mudanças paradigmáticas do significado de desenvolvimento nestas socieades é o que propõe este ensaio.