bluuebunny/crossref_metadata_2025_split huggingface dataset:
Printability study of metal ion crosslinked PEG-catechol based inks
Authors: Włodarczyk-Biegun Małgorzata K. , Paez Julieta I. , Villiou Maria , Feng Jun , del Campo Aranzazu 
Published: April 2019

AbstractInspired by reversible networks present in nature, we have explored the printability of catechol functionalized polyethylene glycol (PEG) based inks with metal-coordination crosslinking. Material formulations containing Al3+, Fe3+or V3+as crosslinking ions were tested. The printability and shape fidelity were dependent on the ink composition (metal ion type, pH, PEG molecular weight) and printing parameters (extrusion pressure and printing speed). The relaxation time, recovery rate and viscosity of the inks were analyzed in rheology studies and correlated with thermodynamic and ligand exchange kinetic constants of the dynamic bonds and the printing performance (i.e. shape fidelity of the printed structures). The relevance of the relaxation time and ligand exchange kinetics for printability was demonstrated. Cells seeded on the crosslinked materials were viable, indicating the potential of the formulations to be used as inks for cell encapsulation. The proposed dynamic ink design offers significant flexibility for 3D (bio)printing, and enables straightforward adjustment of the printable formulation to meet application-specific needs.
A validated strategy to infer protein biomarkers from RNA-Seq by combining multiple mRNA splice variants and time-delay
Authors: Magnusson Rasmus , Rundquist Olof , Kim Min Jung , Hellberg Sandra , Na Chan Hyun , Benson Mikael , Gomez-Cabrero David , Kockum Ingrid , Tegnér Jesper , Piehl Fredrik , Jagodic Maja , Mellergård Johan , Altafini Claudio , Ernerudh Jan , Jenmalm Maria C. , Nestor Colm E. , Kim Min-Sik , Gustafsson Mika 
Published: April 2019

AbstractBackgroundProfiling of mRNA expression is an important method to identify biomarkers but complicated by limited correlations between mRNA expression and protein abundance. We hypothesised that these correlations could be improved by mathematical models based on measuring splice variants and time delay in protein translation.MethodsWe characterised time-series of primary human naïve CD4+ T cells during early T-helper type 1 differentiation with RNA-sequencing and mass-spectrometry proteomics. We then performed computational time-series analysis in this system and in two other key human and murine immune cell types. Linear mathematical mixed time-delayed splice variant models were used to predict protein abundances, and the models were validated using out-of-sample predictions. Lastly, we re-analysed RNA-Seq datasets to evaluate biomarker discovery in five T-cell associated diseases, validating the findings for multiple sclerosis (MS) and asthma.ResultsThe new models demonstrated median correlations of mRNA-to-protein abundance of 0.79-0.94, significantly out-performing models not including the usage of multiple splice variants and time-delays, as shown in cross-validation tests. Our mathematical models provided more differentially expressed proteins between patients and controls in all five diseases. Moreover, analysis of these proteins in asthma and MS supported their relevance. One marker, sCD27, was clinically validated in MS using two independent cohorts, for treatment response and prognosis.ConclusionOur splice variant and time-delay models substantially improved the prediction of protein abundance from mRNA data in three immune cell-types. The models provided valuable biomarker candidates, which were validated in clinical studies of MS and asthma. We propose that our strategy is generally applicable for biomarker discovery.
Genomic Prediction of Depression Risk and Resilience Under Stress
Authors: Fang Yu , Scott Laura , Song Peter , Burmeister Margit , Sen Srijan 
Published: April 2019

AbstractAdvancing our ability to predict who is likely to develop depression in response to stress holds great potential in reducing the burden of the disorder. Large-scale genome-wide association studies (GWAS) of depression have, for the first time, provided a basis for meaningful depression polygenic risk score construction (MDD-PRS). The Intern Health Study utilizes the predictable and large increase in depression with physician training stress to identify predictors of depression. Applying the MDD-PRS derived from the PGC2/23andMe GWAS to 5,227 training physicians, we found that MDD-PRS predicted depression under training stress (beta=0.082, p=2.1×10−12) and that MDD-PRS was significantly more strongly associated with depression under stress than at baseline (MDD-PRS × stress interaction - beta=0.029, p=0.02). While known risk factors accounted for 85.6% of the association between MDD-PRS and depression at baseline, they only accounted for 55.4% of the association between MDD-PRS and depression under stress, suggesting that MDD-PRS can add unique predictive power to existing models of depression under stress. Further, we found that low MDD-PRS may have particular utility in identifying individuals with high resilience. Together, these findings suggest that polygenic risk score holds promise in furthering our ability to predict vulnerability and resilience under stress.
Symptom Severity in Youths with Attention Deficit Hyperactivity Disorder Associated with Normalizing Effects of Treatment on fMRI Response during a Stop Signal Task
Authors: Hegarty Catherine E. , Gupta Mohan W. , Miller Eric , Terashima Kevin , Loo Sandra , McCracken James , McGough James , Bilder Robert M. , Poldrack Russell A. , Galvan Adriana , Bookheimer Susan 
Published: April 2019

AbstractInhibitory control deficits represent one of many core cognitive deficits in Attention-Deficit/Hyperactivity Disorder (ADHD). Neuroimaging studies suggest that individuals with ADHD exhibit atypical engagement of neural systems during response inhibition, but the exact nature of this phenotype is obscured by mixed findings. We tested whether drug-free youths with ADHD (n=30, ages 7-14 years, 10 female) exhibited atypical neural correlates of response inhibition, as measured with a stop signal task and fMRI, compared to matched controls. We next investigated medication effects and whether there was a relationship between symptom severity and medication effects on the fMRI-evaluated signal. Finally, we tested for a significant difference between effects of monotherapy and combined pharmacological treatment. Patients showed significantly slower stop signal response time and lower percent inhibition, but no significant differences in the neural correlates of response inhibition relative to controls. However, patients showed significantly elevated signal in frontostriatal regions during responses. Prefrontal signal in patients was positively associated with reaction time variability in patients, and change (medicated – drug free) in the prefrontal signal was significantly associated with symptom scores, such that patients with elevated symptoms had greater BOLD signal reduction following treatment. Medication significantly improved go response time median and variability as well as stop signal reaction time, but there were no significant effects of medication or treatment type on BOLD signal. These findings challenge the notion of frontostriatal hypoactivation during response inhibition as a biomarker for ADHD and suggest that symptom severity may be associated with response to medication.
PBS3 is the missing link in plant-specific isochorismate-derived salicylic acid biosynthesis
Authors: Rekhter Dmitrij , Lüdke Daniel , Ding Yuli , Feussner Kirstin , Zienkiewicz Krzysztof , Lipka Volker , Wiermer Marcel , Zhang Yuelin , Feussner Ivo 
Published: April 2019

AbstractThe phytohormone salicylic acid (SA) is a central regulator of plant immunity. Despite such functional importance, our knowledge of its biosynthesis is incomplete. Previous work showed that SA is synthesized from chorismic acid in plastids. The bulk of pathogen-induced SA derives from isochorismate generated by the catalytic activity of ISOCHORISMATE SYNTHASE1 (ICS1). How and in which cellular compartment isochorismate is converted to SA is unknown. Here we show that the pathway downstream of isochorismate requires only two additional proteins: the plastidial isochorismate exporter ENHANCED DISEASE SUSCEPTIBILITY5 (EDS5) and the cytosolic amido-transferase AvrPphB SUSCEPTIBLE3 (PBS3). PBS3 catalyzes the conjugation of glutamate to isochorismate. The reaction product isochorismate-9-glutamate spontaneously decomposes into enolpyruvyl-N-glutamate and SA. This previously unknown reaction mechanism appears to be conserved throughout the plant kingdom.One Sentence SummarySalicylic acid is synthesized via isochorismate-9-glutamate by PBS3.
Conceptual design of an aircraft for Mars mission
Authors: Kwiek Agnieszka 
Published: April 2019

Purpose
The purpose of this paper is to present the results of a conceptual design of Martian aircraft. This study focuses on the aerodynamic and longitudinal dynamic stability analysis. The main research questions are as follows: Does a tailless aircraft configuration can be used for Martian aircraft? How to the short period characteristic can be improved by side plates modification?

Design/methodology/approach
Because of a conceptual design stage of this Martian aircraft, aerodynamic characterises were computed by the Panukl package by using the potential flow model. The longitudinal dynamic stability was computed by MATLAB code, and the derivatives computed by the SDSA software were used as the input data. Different aircraft configurations have been studied, including different wing’s aerofoils and configurations of the side plate.

Findings
This paper presents results of aerodynamic characteristics computations and longitudinal dynamic stability analysis. This paper shows that tailless aircraft configuration has potential to be used as Martian aircraft. Moreover, the study of the impact of side plates’ configurations on the longitudinal dynamic stability is presented. This investigation reveals that the most effective method to improve the short period damping ratio is to change the height of the bottom plate.

Practical implications
The presented result might be useful in case of further design of the aircrafts for the Mars mission and designing the aircrafts in a tailless configuration.

Social implications
It is considered by the human expedition that Mars is the most probable planet to explore. This paper presents the conceptual study of aircraft which can be used to take the high-resolution pictures of the surface of Mars, which can be crucial to find the right place to establish a potential Martian base.

Originality/value
Most of aircrafts proposed for the Mars mission are designed in a configuration with a classic tail; this paper shows a preliminary calculation of the tailless Martian aircraft. Moreover, this paper shows the results of a dynamic stability analysis, where similar papers about aircrafts for the Mars mission do not show such outcomes, especially in the case of the tailless configuration. Moreover, this paper presents the results of the dynamic stability analysis of tailless aircraft with different configurations of the side plates.
Estimating farm-level financing gap: a technical efficiency approach
Authors: Ojo Mathew Paul , Ayanwale Adeolu Babatunde 
Published: April 2019

Purpose
Much attention has been paid to farm credit access with less focus on determining the actual credit amount needed to bring about a specified increase in productivity relative to the finance being sought. The paper aims to discuss this issue.

Design/methodology/approach
Using 2016 cross-sectional data of plantain farmers, the authors employ the Cobb–Douglas stochastic frontier production function to determine the technical efficiency (TE) of each farmer. Current plantain quantity produced by farmers and the TE are then used to estimate plantain quantity at a target efficiency. The finance needed to produce at the target efficiency is estimated using the Harrod–Domar (HD) growth equation and the authors then subtract the farmers’ savings from the estimated amount to determine the financing gap of the farmers.

Findings
Results of this study show that the actual amount required to improve the productivity of farmers to target levels of TE can be estimated and that credit amount granted to farmers can be tied to a specific production efficiency. Credit schemes with interest rates below 9 per cent are more beneficial to farmers while access to credit is determined by interest rate, education, credit process duration, land ownership and asset value in the study area.

Research limitations/implications
The implication of this research is that it opens up the possibility of further exploring the application of the HD theory at the micro level.

Practical implications
The findings in this study have important implications on the provision of agricultural credit to small farmers. The first is that the TE of farmers plays a very critical role in determining the actual amount of credit needed to bridge the farm-level financing gap and impact positively on productivity. Second, while it is important to bridge the farm-level financing gap, this can only be beneficial to the farmers at single-digit interest rates below 7 per cent. Finally, granting of credit to farmers can be tied to specific production increase target to reduce indiscipline and mismanagement in credit use.

Social implications
The findings of this study will go along in helping to prevent mismanagement and indiscipline in the use of scarce financial resources in agricultural production.

Originality/value
This study is the first of its kind, using TE and bringing the HD equation down to the farm level to estimate the exact amount required by farmers to bring about specific increase in production, determining the credit amount beyond which mismanagement may set in.
A personal construct approach to employability: comparing stakeholders’ implicit theories
Authors: Williams Stella , Karypidou Anatoli , Steele Catherine , Dodd Lorna 
Published: April 2019

PurposeThe purpose of this paper is to adopt the perspective of personal construct theory to conceptualise employability. The study explores differences in the implicit employability theories of those involved in developing employability (educators) and those selecting and recruiting higher education (HE) students and graduates (employers).Design/methodology/approachA repertory grid technique (RGT) was employed to uncover the implicit theories of 22 employers and 14 educators across the UK.FindingsA total of 717 constructs were elicited. A differential analysis of data gathered demonstrated several areas of consensus among employers and educators (including emotional management, confidence, professionalism), as well as divergence in representations of commitment, proactivity, interpersonal competencies and vision to the conceptualisation of employability.Practical implicationsFindings from this analysis indicate a need to integrate group process assessments within undergraduate programmes and recruitment procedures.Originality/valueThis study represents a personal construct approach to employability, utilising the unique value of RGT to further inform our understanding of employability within an HE context. This study contributes to an understanding of employability as a continually re-constructed concept. This study provides insights to its nature via two information rich cases that have extensive knowledge on the topic.
Enabling sustainable built heritage revitalisation from a social and technical perspective
Authors: Ho Daniel , Hou Huiying 
Published: April 2019

Purpose
This study aims to investigate built heritage revitalisation projects in Hong Kong through a case study.

Design/methodology/approach
For this study, a representative built heritage revitalisation project in Hong Kong is selected study revitalisation in practice in Hong Kong. The case study adopts content analysis as the main method of analysis. It involves counting keywords, comparing content, categorising content patterns and interpreting the content of documents.

Findings
The findings reveal that in the revitalisation process, there is significant fragmentation in collaboration among government sectors and in conservation documentation and that an effective knowledge sharing mechanism and valid public engagement is needed. A conceptual framework of social network-enabled building information modelling (BIM) platform is proposed to enhance knowledge sharing and cross-sector collaboration.

Practical implications
The conceptual framework developed based on the case study is expected to bring practical implications to urban regeneration policies in Hong Kong.

Originality/value
This study views built heritage revitalisation practice as different individual projects and provides a social and technical perspective to investigate built heritage revitalisation.
Households’ perception of flood risk and health impact of exposure to flooding in flood-prone informal settlements in the coastal city of Mombasa
Authors: Okaka Fredrick Okoth , Odhiambo Beneah D.O. 
Published: April 2019

Purpose
Mombasa City in Kenya is one of the most vulnerable towns to flood risk due to its low-lying coastal location. Those at the highest risk in the city are households living in the flood-prone informal settlements. However, little is known about the perception of these vulnerable households to the flood risks and its health impacts, which is important for developing effective long-term adaptation strategies. The purpose of this paper is to examine the general perception of the residents regarding flood risks, its impact on their health and their adaptation strategies.

Design/methodology/approach
This study surveyed 390 randomly selected households in three informal settlements in the city of Mombasa using a semi-structured questionnaire. This was supplemented with six focus group discussions (FDGs) and six key informant interviews (KIIs).

Findings
The majority of respondent households perceive future flooding as high risk or severe with high negative health impact. Despite this, many do not evacuate their homes because they do not have alternative places to move to. Flooding was indicated to have had a negative physical and mental health impact on members of households. Although majority of households had taken some adaptation measures, most of these were short term, mainly due to financial constraints, lack of knowledge and government support. Perception of flood risk and gender were found to have a strong influence on taking long-term adaptation measures at the household level.

Practical implications
Reducing flood risk and averting its health consequences in flood-prone informal settlements require empowering and supporting those living in these areas with ability to initiate long-term adaptation measures and creating awareness about future risks.

Originality/value
This study provides evidence about how residents of flood-prone informal settlements perceive flood risk and how the exposures to perennial flooding impact their health. The paper augments existing knowledge of flood risk in poor urban neighborhoods of developing countries.
The effect of climate change adaptation strategy on farm households welfare in the Nile basin of Ethiopia
Authors: Asmare Fissha , Teklewold Hailemariam , Mekonnen Alemu 
Published: April 2019

Purpose
This study aims to examine the effect of crop diversification (CD), as a climate change adaptation strategy, on farm household’s welfare in terms of farm income and demand for labor. It explores whether adoption of CD is a win-win strategy on household income and demand for on-farm labor. It also examines the determinants of rural household’s net farm income and family labor demand.

Design/methodology/approach
A household-plot level data were collected in 2015 from 929 rural farm households and 4,778 plots in the Nile Basin of Ethiopia. The data comprise farm and household characteristics accompanied by geo-referenced climate data such as long-term average temperature and amount and variability of growing season rainfall. The authors estimate an endogenous switching regression model to measure the effect of CD on the farm household’s welfare, using net farm income and household labor demand as a welfare indicator.

Findings
The results indicate heterogeneous effects of climate variables on farm income between adopters and non-adopters of CD. The study also confirms the win-win effect of adoption of CD with a positive and significant effect on farm income and a reduction in demand for on-farm labor. The results suggest that adoption of CD helps improve the well-being of farm households and build a resilient agricultural system.

Research limitations/implications
As the study used a cross-sectional data, it is limited to show the time effect of practicing CD on the household’s welfare.

Originality/value
First, the authors investigate, to their knowledge for the first time, the existence of synergy or tradeoff in the effect of CD on two dimensions of rural households’ welfare (net farm income and labor demand). Second, they investigate the heterogeneous effect of climate change adaptation strategies on the farm household’s welfare between adopters and non-adopters. This is unlike previous studies that consider climate change adaptation strategies as having a homogeneous effect. However, this approach is inappropriate since the effect of adaptation strategies is different for adopters and non-adopters.
The professional development needs for the use of educational technology
Authors: Li Kam-Cheong , Wong Billy Tak-Ming 
Published: April 2019

Purpose
This study aimed to identify the professional development needs of academics in Hong Kong higher education for the use of educational technology.

Design/methodology/approach
An online survey was conducted in 2017, which involved 374 academics from Hong Kong higher education institutions. The survey covered their perception and use of educational technology for professional activities and their relevant professional development needs.

Findings
The results showed an overall positive perception by the academics of the usefulness of online learning with the aid of technology, which was regarded as an effective complement to face-to-face learning. However, their use of educational technology focused only on general online applications, such as document and video-sharing tools, and e-learning platforms. Among various professional development needs, those related to the use of specific educational software with sharing of practical examples were considered to be most highly desired by the academics. In addition, the academics working in lecturer positions tended to use more online applications and had a higher need for professional development, than those with more teaching experience.

Originality/value
The findings contribute to identifying the current status of the use of educational technology and the professional development needs among academics in Hong Kong, as well as the differences between academics in different job positions and with different amounts of teaching experience. The results help in designing suitable professional development activities which address the specific needs of academics.