bluuebunny/crossref_metadata_2025_split huggingface dataset:
Diagnostic assessment of a deep learning system for detecting atrial fibrillation in pulse waveforms
Authors: Poh Ming-Zher , Poh Yukkee Cheung , Chan Pak-Hei , Wong Chun-Ka , Pun Louise , Leung Wangie Wan-Chiu , Wong Yu-Fai , Wong Michelle Man-Ying , Chu Daniel Wai-Sing , Siu Chung-Wah 
Published: May 2018

ObjectiveTo evaluate the diagnostic performance of a deep learning system for automated detection of atrial fibrillation (AF) in photoplethysmographic (PPG) pulse waveforms.MethodsWe trained a deep convolutional neural network (DCNN) to detect AF in 17 s PPG waveforms using a training data set of 149 048 PPG waveforms constructed from several publicly available PPG databases. The DCNN was validated using an independent test data set of 3039 smartphone-acquired PPG waveforms from adults at high risk of AF at a general outpatient clinic against ECG tracings reviewed by two cardiologists. Six established AF detectors based on handcrafted features were evaluated on the same test data set for performance comparison.ResultsIn the validation data set (3039 PPG waveforms) consisting of three sequential PPG waveforms from 1013 participants (mean (SD) age, 68.4 (12.2) years; 46.8% men), the prevalence of AF was 2.8%. The area under the receiver operating characteristic curve (AUC) of the DCNN for AF detection was 0.997 (95% CI 0.996 to 0.999) and was significantly higher than all the other AF detectors (AUC range: 0.924–0.985). The sensitivity of the DCNN was 95.2% (95% CI 88.3% to 98.7%), specificity was 99.0% (95% CI 98.6% to 99.3%), positive predictive value (PPV) was 72.7% (95% CI 65.1% to 79.3%) and negative predictive value (NPV) was 99.9% (95% CI 99.7% to 100%) using a single 17 s PPG waveform. Using the three sequential PPG waveforms in combination (<1 min in total), the sensitivity was 100.0% (95% CI 87.7% to 100%), specificity was 99.6% (95% CI 99.0% to 99.9%), PPV was 87.5% (95% CI 72.5% to 94.9%) and NPV was 100% (95% CI 99.4% to 100%).ConclusionsIn this evaluation of PPG waveforms from adults screened for AF in a real-world primary care setting, the DCNN had high sensitivity, specificity, PPV and NPV for detecting AF, outperforming other state-of-the-art methods based on handcrafted features.
Asymptomatic young man with an incidental murmur
Authors: Shojaeifard Maryam , Pouraliakbar Hamid Reza , Houshmand Golnaz 
Published: May 2018

Clinical introductionA 32-year old man was referred to our institution for transthoracic echocardiography (TTE) following detection of an incidental murmur on physical examination before blood donation. He was asymptomatic with no significant medical history. Physical examination revealed dual heart sounds with a grade II/VI systolic murmur heard in the left sternal border. An ECG was in normal sinus rhythm. TTE was performed (figure 1A–C, online supplementary videos 1–4) followed by cardiac CT angiography (CTA) (figure 1D,E).Figure 1(A) Transthoracic echocardiography, parasternal left ventricular long axis view. (B) Colour Doppler of modified short axis in the mid-left ventricular level. (C) Doppler flow velocity profile. (D) Cardiac CT angiography (CTA) sagittal reconstruction. (E) Three-dimensional CTA reconstruction of the heart.QuestionWhat is the diagnosis?Pericardial cyst.Ventricular septal defect.Kawasaki.Anomalous left coronary artery from pulmonary artery (ALCAPA).
Preparing for the Practice Standards Scheme medicines assessment: part 1
Authors: Mosedale Pam 
Published: May 2018

If you have a Practice Standards Scheme assessment approaching and are responsible for meeting the standards for one of the largest modules – medicines – then this article will be helpful in ensuring that your practice is prepared and meeting the standards. The article is in two parts: this first part deals with changes to the scheme, medicines records, storage of medicines and prescribing, dispensing and supplying procedures.The second part, which will be published in the July/August issue of In Practice, will cover controlled drugs, unauthorised medicines use and responsible use of antimicrobials and anthelmintics.
How tobacco companies have used package quantity for consumer targeting
Authors: Persoskie Alexander , Donaldson Elisabeth A , Ryant Chase 
Published: May 2018

IntroductionPackage quantity refers to the number of cigarettes or amount of other tobacco product in a package. Many countries restrict minimum cigarette package quantities to avoid low-cost packs that may lower barriers to youth smoking.MethodsWe reviewed Truth Tobacco Industry Documents to understand tobacco companies’ rationales for introducing new package quantities, including companies’ expectations and research regarding how package quantity may influence consumer behaviour. A snowball sampling method (phase 1), a static search string (phase 2) and a follow-up snowball search (phase 3) identified 216 documents, mostly from the 1980s and 1990s, concerning cigarettes (200), roll-your-own tobacco (9), smokeless tobacco (6) and ‘smokeless cigarettes’ (1).ResultsCompanies introduced small and large packages to motivate brand-switching and continued use among current users when faced with low market share or threats such as tax-induced price increases or competitors’ use of price promotions. Companies developed and evaluated package quantities for specific brands and consumer segments. Large packages offered value-for-money and matched long-term, heavy users’ consumption rates. Small packages were cheaper, matched consumption rates of newer and lighter users, and increased products’ novelty, ease of carrying and perceived freshness. Some users also preferred small packages as a way to try to limit consumption or quit.ConclusionIndustry documents speculated about many potential effects of package quantity on appeal and use, depending on brand and consumer segment. The search was non-exhaustive, and we could not assess the quality of much of the research or other information on which the documents relied.
Effect of changes in management practices and animal performance on ammonia emissions from Canadian beef production in 1981 as compared with 2011
Authors: Legesse Getahun , Kroebel Roland , Alemu Aklilu W. , Ominski Kim H. , McGeough Emma J. , Beauchemin Karen A. , Chai Lilong , Bittman Shabtai , McAllister Tim A. 
Published: May 2018

The present study compared ammonia (NH3) emissions from Canadian beef production in 1981–2011. Temporal and regional differences in cattle categories, feed types and management systems, average daily gains, carcass weights, and manure handling practices were considered. A scenario-based sensitivity analysis in 2011 estimated the impact of substituting corn dried distillers’ grains with solubles (DDGS) for grain in feedlot diets. On average, 22% of the total nitrogen (N) intake was lost as ammoniacal nitrogen (NH3-N) in both years. Manure emission sources were consistent across years, averaging 12%, 40%, 28%, and 21% for grazing, confinement, storage, and land spreading, respectively. Emissions per animal in 1981 and 2011 were 16.0 and 18.4 kg NH3 animal−1 yr−1, respectively. On an intensity basis, kilogram of NH3 emitted per kilogram of beef decreased 20%, from 0.17 in 1981 to 0.14 in 2011. This reduction was attributed to increases in reproductive efficiency, average daily gain and carcass weight, and improved breeding herd productivity. In 2011, substituting DDGS for grain in feedlot diets increased total NH3 emissions and losses per animal. Although addition of by-products from the bioethanol industry can lower diet costs, it will be at the expense of an increase in NH3 emissions.
Pen enrichment and sex interaction on growth performance and metabolite concentrations of autochthonous Windsnyer pigs kept in a high stocking density
Authors: Mkwanazi M.V. , Kanengoni A.T. , Chimonyo M. 
Published: May 2018

The objective of the study was to determine the interaction of pen enrichment and sex on growth performance and blood metabolite concentrations of Windsnyer pigs. Forty-eight growing Windsnyer pigs of both sexes, with an average initial body weight of 21.6 (±9.01) kg were used. Daily feed intake and weekly body weights for each pen were measured. Blood was collected at the end of the experiment. Pen environment did not affect average daily feed intake (ADFI) and average daily gain. There was a pen environment and sex interaction on ADFI. Females in barren pens had higher ADFI than enriched females but ADFI in barren and enriched pens was similar for male pigs. Pigs in enriched environment were more efficient in converting feed into body weight than those in barren environment. There was an interaction of pen environment and sex on glucose, blood urea nitrogen (BUN), and alkaline phosphatase. Enriched males had higher albumin than males in barren environment. Enriched females had higher BUN than females in barren environment. It was concluded that enriched Windsnyer pigs housed at a density of 0.39 m2 per pig, particularly females, perform better than those in barren environments.
XYZ-SU3 breakings from Laplace sum rules at higher orders
Authors: Albuquerque R. , Narison S. , Rabetiarivony D. , Randriamanatrika G. 
Published: May 2018

We present new compact integrated expressions of SU3 breaking corrections to QCD spectral functions of heavy–light molecules and four-quark [Formula: see text]-like states at lowest order (LO) of perturbative (PT) QCD and up to [Formula: see text] condensates of the Operator Product Expansion (OPE). Including next-to-next-to-leading order (N2LO) PT corrections in the chiral limit and next-to-leading order (NLO) SU3 PT corrections, which we have estimated by assuming the factorization of the four-quark spectral functions, we improve previous LO results for the [Formula: see text]-like masses and decay constants from QCD spectral sum rules (QSSR). Systematic errors are estimated from a geometric growth of the higher order PT corrections and from some partially known [Formula: see text] nonperturbative contributions. Our optimal results, based on stability criteria, are summarized in Tables 18–21 while the [Formula: see text] and [Formula: see text] channels are compared with some existing LO results in Table 22. One can note that, in most channels, the SU3 corrections on the meson masses are tiny: [Formula: see text] (respectively [Formula: see text]) for the [Formula: see text] (respectively [Formula: see text])-quark channel but can be large for the couplings ([Formula: see text]). Within the lowest dimension currents, most of the [Formula: see text] and [Formula: see text] states are below the physical thresholds while our predictions cannot discriminate a molecule from a four-quark state. A comparison with the masses of some experimental candidates indicates that the [Formula: see text] [Formula: see text] might have a large [Formula: see text] molecule component while an interpretation of the [Formula: see text] candidates as four-quark ground states is not supported by our findings. The [Formula: see text] [Formula: see text] and [Formula: see text] are compatible with the [Formula: see text], [Formula: see text] molecules and/or with the axial-vector [Formula: see text] four-quark ground state. Our results for the [Formula: see text], [Formula: see text] and for different beauty states can be tested in the future data. Finally, we revisit our previous estimates1 for the [Formula: see text] and [Formula: see text] and present new results for the [Formula: see text].
Circuit presentation and lattice stick number with exactly four z-sticks
Authors: Kim Hyoungjun , No Sungjong 
Published: May 2018

The lattice stick number [Formula: see text] of a link [Formula: see text] is defined to be the minimal number of straight line segments required to construct a stick presentation of [Formula: see text] in the cubic lattice. Hong, No and Oh [Upper bound on lattice stick number of knots, Math. Proc. Cambridge Philos. Soc. 155 (2013) 173–179] found a general upper bound [Formula: see text]. A rational link can be represented by a lattice presentation with exactly 4 [Formula: see text]-sticks. An [Formula: see text]-circuit is the disjoint union of [Formula: see text] arcs in the lattice plane [Formula: see text]. An [Formula: see text]-circuit presentation is an embedding obtained from the [Formula: see text]-circuit by connecting each [Formula: see text] pair of vertices with one line segment above the circuit. By using a two-circuit presentation, we can easily find the lattice presentation with exactly four [Formula: see text]-sticks. In this paper, we show that an upper bound for the lattice stick number of rational [Formula: see text]-links realized with exactly four [Formula: see text]-sticks is [Formula: see text]. Furthermore, it is [Formula: see text] if [Formula: see text] is a two-component link.
Manganese transport and toxicity in polarized WIF-B hepatocytes
Authors: Thompson Khristy J. , Hein Jennifer , Baez Andrew , Sosa Jose Carlo , Wessling-Resnick Marianne 
Published: May 2018

Manganese (Mn) toxicity arises from nutritional problems, community and occupational exposures, and genetic risks. Mn blood levels are controlled by hepatobiliary clearance. The goals of this study were to determine the cellular distribution of Mn transporters in polarized hepatocytes, to establish an in vitro assay for hepatocyte Mn efflux, and to examine possible roles the Mn transporters would play in metal import and export. For these experiments, hepatocytoma WIF-B cells were grown for 12–14 days to achieve maximal polarity. Immunoblots showed that Mn transporters ZIP8, ZnT10, ferroportin (Fpn), and ZIP14 were present. Indirect immunofluorescence microscopy localized Fpn and ZIP14 to WIF-B cell basolateral domains whereas ZnT10 and ZIP8 associated with intracellular vesicular compartments. ZIP8-positive structures were distributed uniformly throughout the cytoplasm, but ZnT10-positive vesicles were adjacent to apical bile compartments. WIF-B cells were sensitive to Mn toxicity, showing decreased viability after 16 h exposure to >250 μM MnCl2. However, the hepatocytes were resistant to 4-h exposures of up to 500 μM MnCl2despite 50-fold increased Mn content. Washout experiments showed time-dependent efflux with 80% Mn released after a 4 h chase period. Hepcidin reduced levels of Fpn in WIF-B cells, clearing Fpn from the cell surface, but Mn efflux was unaffected. The secretory inhibitor, brefeldin A, did block release of Mn from WIF-B cells, suggesting vesicle fusion may be involved in export. These results point to a possible role of ZnT10 to import Mn into vesicles that subsequently fuse with the apical membrane and empty their contents into bile.NEW & NOTEWORTHY Polarized WIF-B hepatocytes express manganese (Mn) transporters ZIP8, ZnT10, ferroportin (Fpn), and ZIP14. Fpn and ZIP14 localize to basolateral domains. ZnT10-positive vesicles were adjacent to apical bile compartments, and ZIP8-positive vesicles were distributed uniformly throughout the cytoplasm. WIF-B hepatocyte Mn export was resistant to hepcidin but inhibited by brefeldin A, pointing to an efflux mechanism involving ZnT10-mediated uptake of Mn into vesicles that subsequently fuse with and empty their contents across the apical bile canalicular membrane.
NaV1.9 channels in muscle afferent neurons and axons
Authors: Marler Tyler L. , Wright Andrew B. , Elmslie Kristina L. , Heier Ankeeta K. , Remily Ethan , Kim-Han Jeong Sook , Ramachandra Renuka , Elmslie Keith S. 
Published: May 2018

The exercise pressor reflex (EPR) is activated by muscle contractions to increase heart rate and blood pressure during exercise. While this reflex is beneficial in healthy individuals, the reflex activity is exaggerated in patients with cardiovascular disease, which is associated with increased mortality. Group III and IV afferents mediate the EPR and have been shown to express both tetrodotoxin-sensitive (TTX-S, NaV1.6, and NaV1.7) and -resistant (TTX-R, NaV1.8, and NaV1.9) voltage-gated sodium (NaV) channels, but NaV1.9 current has not yet been demonstrated. Using a F−-containing internal solution, we found a NaVcurrent in muscle afferent neurons that activates at around −70 mV with slow activation and inactivation kinetics, as expected from NaV1.9 current. However, this current ran down with time, which resulted, at least in part, from increased steady-state inactivation since it was slowed by both holding potential hyperpolarization and a depolarized shift of the gating properties. We further show that, following NaV1.9 current rundown (internal F−), application of the NaV1.8 channel blocker A803467 inhibited significantly more TTX-R current than we had previously observed (internal Cl−), which suggests that NaV1.9 current did not rundown with that internal solution. Using immunohistochemistry, we found that the majority of group IV somata and axons were NaV1.9 positive. The majority of small diameter myelinated afferent somata (putative group III) were also NaV1.9 positive, but myelinated muscle afferent axons were rarely labeled. The presence of NaV1.9 channels in muscle afferents supports a role for these channels in activation and maintenance of the EPR.NEW & NOTEWORTHY Small diameter muscle afferents signal pain and muscle activity levels. The muscle activity signals drive the cardiovascular system to increase muscle blood flow, but these signals can become exaggerated in cardiovascular disease to exacerbate cardiac damage. The voltage-dependent sodium channel NaV1.9 plays a unique role in controlling afferent excitability. We show that NaV1.9 channels are expressed in muscle afferents, which supports these channels as a target for drug development to control hyperactivity of these neurons.
Deficiency of FAM3D (Family With Sequence Similarity 3, Member D), A Novel Chemokine, Attenuates Neutrophil Recruitment and Ameliorates Abdominal Aortic Aneurysm Development
Authors: He Li , Fu Yi , Deng Jingna , Shen Yicong , Wang Yingbao , Yu Fang , Xie Nan , Chen Zhongjiang , Hong Tianpei , Peng Xinjian , Li Qingqing , Zhou Jing , Han Jingyan , Wang Ying , Xi Jianzhong , Kong Wei 
Published: May 2018

Objective—
Chemokine-mediated neutrophil recruitment contributes to the pathogenesis of abdominal aortic aneurysm (AAA) and may serve as a promising therapeutic target. FAM3D (family with sequence similarity 3, member D) is a recently identified novel chemokine. Here, we aimed to explore the role of FAM3D in neutrophil recruitment and AAA development.

Approach and Results—

FAM3D was markedly upregulated in human AAA tissues, as well as both elastase- and CaPO
4
-induced mouse aneurysmal aortas. FAM3D deficiency significantly attenuated the development of AAA in both mouse models. Flow cytometry analysis indicated that
FAM3D
−/−
mice exhibited decreased neutrophil infiltration in the aorta during the early stage of AAA formation compared with their wild-type littermates. Moreover, application of FAM3D-neutralizing antibody 6D7 through intraperitoneal injection markedly ameliorated elastase-induced AAA formation and neutrophil infiltration. Further, in vitro coculture experiments with FAM3D-neutralizing antibody 6D7 and in vivo intravital microscopic analysis indicated that endothelial cell–derived FAM3D induced neutrophil recruitment. Mechanistically, FAM3D upregulated and activated Mac-1 (macrophage-1 antigen) in neutrophils, whereas inhibition of FPR1 (formyl peptide receptor 1) or FPR2 significantly blocked FAM3D-induced Mac-1 activation, indicating that the effect of FAM3D was dependent on both FPRs. Moreover, specific inhibitors of FPR signaling related to Gi protein or β-arrestin inhibited FAM3D-activated Mac-1 in vitro, whereas FAM3D deficiency decreased the activation of both FPR-Gi protein and β-arrestin signaling in neutrophils in vivo.

Conclusions—
FAM3D, as a dual agonist of FPR1 and FPR2, induced Mac-1-mediated neutrophil recruitment and aggravated AAA development through FPR-related Gi protein and β-arrestin signaling.
Release calls of Moroccan spadefoot toad, Pelobates varaldii (Anura, Pelobatidae)
Authors: Márquez Rafael , Beltrán Juan F. , Pita-Vaca Ignacio , Samlali Mohamed Amine , S’Khifa Abderrahim , Slimani Tahar , El Mouden El Hassan 
Published: May 2018

Abstract
Release calls of Pelobates varaldii Pasteur and Bons (1959) are described quantitatively based on airborne recordings obtained from 4 males and 12 females from a population of the extreme north of its range. The calls are sequences of pulsed notes with a variable number of pulses per note. To the best of our knowledge this is the first report on the acoustic repertoire of this endemic endangered species from Morocco.
Postvernacular Prufrock
Authors: Boyden Michael 
Published: May 2018

Abstract
This article offers an explorative reading of a parodic Yiddish rendition of T.S. Eliot’s “The Love Song of J. Alfred Prufrock” entitled “Der shir hashirim fun Mendl Pumshtok” that was composed by Isaac Rosenfeld and Saul Bellow during their student years in Chicago. The article argues that, by measuring themselves against the main representative of high modernism and by giving a markedly ethnic inflection to Eliot’s poem, Brooks and Rosenfeld attempted to transcend the assumed provincialism of their situation and elbow their way into the American literary canon. More generally, the article suggests that parodic “translations” of this kind, by highlighting the postvernacular dimension of literary language (Shandler), extend the purview of translingual studies by valuing performativity, orality, and collaboration over and against competency as defining elements of linguistic border crossing in an age that has sometimes too hastily been characterized as post-national or post-Romantic. The article thus points to the relevance of what the author calls literary amphilingualism, a prevalent but understudied phenomenon in translingual studies.
Heterographics as a Literary Device
Authors: Bodin Helena 
Published: May 2018

Abstract
Heterographics (“other lettering”) refers to the use of two scripts in one text or a translation of a text from one script to another. How might the occasional use of heterographics in literary texts highlight issues of cultural diversity? Drawing on intermedial theory and studies of literary multilingualism, literary translation, and pluriliteracies, this article examines various functions of heterographics in selected contemporary literary texts. Examples of embedded Greek, Chinese, Cyrillic, and Arabic script are analysed in works published in Swedish, French, and English between 2004 and 2015, selected because they thematise cultural diversity and linguistic boundaries. The conclusion is that heterographic devices emphasise the heteromediality of literary texts, thereby heightening readers’ awareness of the visual-spatial features of literary texts, as well as of the materiality of scripts. Heterographics influence readers’ experiences of cultural affinity or alterity, that is, of inclusion or exclusion, depending on their access to practices of pluriliteracies.
Response to Special Issue of Journal of World Literature on Literary Translingualism
Authors: Kellman Steven G. 
Published: May 2018

Abstract
The articles in this special issue on Literary Translingualism by Helgesson and Kullberg, Robinson, Boyden, and Bodin all insist on language as fluid and non-discrete. What Boyden calls “amphilingualism” is a useful way to describe the porousness of languages. These and other scholars of translingualism are at odds with the ascendant nativism that is enforcing boundaries between nations and languages. Translations further problematize the sovereignty of language and national culture, and they are crucial to the process of elevating a text in the global hypercanon. What Bodin calls “heterographics,” the coexistence of separate scripts within a single text, is a useful extension of literary translingualism.