bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exposure–Response‐Based Product Profile–Driven Clinical Utility Index for Ipatasertib Dose Selection in Prostate Cancer
Authors: Zhu Rui , Poland Bill , Wada Russ , Liu Qi , Musib Luna , Maslyar Daniel , Cho Eunpi , Yu Wei , Ma Han , Jin Jin Yan , Budha Nageshwar 
Published: February 2019

The aims of this work were to characterize ipatasertib exposure–response (E‐R) relationships in a phase II study and to quantitatively assess benefit‐risk using a clinical utility index approach to support ipatasertib phase III dose selection in patients with metastatic castration‐resistant prostate cancer. Logistic regression and Cox proportional‐hazards models characterized E‐R relationships for safety and efficacy endpoints, respectively. Exposure metrics with and without considering dose interruptions/reductions (modifications) were tested in the E‐R models. Despite a steeper E‐R relationship when accounting for dose modifications, similar dose‐response projections were generated. The clinical utility index analysis assessed important attributes, weights, and clinically meaningful cutoff/tradeoff values based on predefined minimal, target, and optimistic product profiles. Ipatasertib 400 mg daily, showing the highest probability of achieving the minimal product profiles and better benefit‐risk balance than other doses (200–500 mg daily), was selected for further development in metastatic castration‐resistant prostate cancer.
The effect of cumin supplementation on metabolic profiles in patients with metabolic syndrome: A randomized, triple blind, placebo‐controlled clinical trial
Authors: Morovati Ashti , Pourghassem Gargari Bahram , Sarbakhsh Parvin , Azari Hushyar , Lotfi‐Dizaji Lida 
Published: February 2019

Metabolic syndrome (MetS) is a cluster of interconnected serious disorders, which is a major health problem whose prevalence is increasing. Oxidative stress and inflammation contribute to the disease pathogenesis and its complications. The present study aimed to investigate the effect of Cuminum cyminum L. (which has antioxidant and anti‐inflammatory properties) essential oil (CuEO) supplementation on inflammatory and antioxidant status in patients with MetS. In this clinical trial, 56 patients with MetS aged 18–60 years received either 75‐mg CuEO or placebo soft gel, thrice daily, for 8 weeks. Data on anthropometric parameters, food consumption, tumor necrosis factor alpha, high‐sensitivity C‐reactive protein, superoxide dismutase (SOD), glutathione peroxidase, catalase, total antioxidant capacity (TAC), and malondialdehyde (MDA) were assessed at the beginning and at the end of the study. Compared with the placebo group, CuEO increased SOD (149.17; 95% CI, [67.93, 230.42]), TAC (0.24; 95% CI, [0.09, 0.38]) and decreased MDA (−0.36; 95% CI, [−0.66, 0.06]), (p < 0.01). In within‐group analysis, CuEO led to 13.3% decrease in MDA and 6.7% increase in TAC levels (p < 0.04). The results indicated that CuEO supplementation can improve some antioxidative indices, as SOD and TAC, while decreasing MDA in patients with MetS.
Low‐complexity adaptive tracking control of MIMO nonlinear systems with unknown control directions
Authors: Zhang Jin‐Xi , Yang Guang‐Hong 
Published: February 2019

SummaryThis paper is concerned with the tracking control problem for a class of multiple‐input–multiple‐output systems with unmatched disturbances and the unknown additive and multiplicative nonlinearities. The objective is to provide a low‐complexity control solution in the sense that (i) approximating structures are not involved, despite unknown nonlinearities and (ii) iterative calculations of command derivatives are avoided in the backstepping design. A robust adaptive control strategy is proposed to fulfill the task. In the control design, a new‐type adaptive law is first developed to update Nussbaum gains to handle control direction uncertainties, while ensuring Nussbaum gains bounded. Then, the potential robustness of error constraint techniques is exploited to counteract the effects of unknown nonlinearities and disturbances and achieve predefined transient and steady‐state tracking performance. Finally, simulation results are given to illustrate the above theoretical findings.
Synthesis and Applications of Red‐Emissive Carbon Dots
Authors: Wang Jianying , Zhu Yuhua , Wang Lei 
Published: February 2019

AbstractCarbon dots (CDs), a new class of fluorescent carbon nanoparticles (less than 10 nm in size), have been widely applied in various fields, including sensors, bioimaging, catalysis, light‐emitting devices (LEDs), and photoelectronic devices, owing to their unique properties such as low toxicity, bio‐compatibility, high photostability, easy surface modification, and up‐conversion fluorescence, over the past decades. Recently, multiple‐color‐emissive CDs, especially red‐emissive CDs (RCDs), have drawn much attention owing to their unique advantages, like the ability to penetrate the animal bodies without the disturbance of strong tissue autofluorescence, multiple‐color fluorescence displaying or sensing, and the capacity to be one essential component to obtain white LED (WLED). In this review, we focused on the progress of recently‐emerging RCDs in the past five years, including their synthetic methods (hydrothermal, solvothermal, reflux condensation and microwave techniques), influencing factors (precursors, solvents, elements doping, surface chemistry) and various applications (bioimaging, sensor, photocatalysis and WLEDs), with a perspective on the future advancements.
The dog (Canis familiaris) as a translational model of autism: It is high time we move from promise to reality
Authors: Topál József , Román Viktor , Turcsán Borbála 
Published: February 2019

Selecting appropriate animal models for a particular human phenomenon is a difficult but important challenge. The difficulty lies in finding animal behaviors that are not only sufficiently relevant and analog to the complex human symptoms (face validity) but also have similar underlying biological and etiological mechanisms (translational or construct validity), and have “human‐like” responses to treatment (predictive validity). Over the past several years, the domestic dog (Canis familiaris) has become increasingly proposed as a model for comparative and translational neuroscience. In parallel to the recent advances in canine behavior research, dogs have also been proposed as a model of many human neuropsychiatric conditions, including autism spectrum disorder (ASD). In this opinion paper we will shortly discuss the challenging nature of autism research then summarize the different neurocognitive frameworks for ASD making the case for a canine model of autism. The translational value of a dog model stems from the recognition that (a) there is a large inter‐individual variability in the manifestation of dogs' social cognitive abilities including both high and low phenotypic extremes; (b) the phenotypic similarity between the dog and human symptoms are much higher than between the rodent and human symptoms; (c) the symptoms are functionally analogous to the human condition; and (d) more likely to have similar etiology.This article is categorized under:

Psychology > Comparative Psychology
Cognitive Biology > Evolutionary Roots of Cognition
Brewster's dark patch: a neglected optical phenomenon in the landscape
Authors: Können G. P. 
Published: February 2019

AbstractUnder clear skies and a low Sun, a dark patch appears on a surface of water at 90° from the Sun. The phenomenon is a naked‐eye manifestation of the polarisation of light of the blue sky. Although this every‐day occuring phenomenon is very conspicuous, it is only since 1980 that it has been discussed in the literature.
Mimicry, deception and competition: The life of competing endogenous RNAs
Authors: Grüll Marc P. , Massé Eric 
Published: February 2019

Since their discovery, small regulatory RNAs (sRNAs) were thought to be regulated exclusively at the transcriptional level. However, accumulating data from recent reports indicate that posttranscriptional signals can also modulate the function and stability of sRNAs. One of these posttranscriptional signals are competing endogenous RNAs (ceRNAs). Commonly called RNA sponges, ceRNAs can effectively sequester sRNAs and prevent them from binding their cognate target messenger RNAs (mRNAs). Subsequently, they prevent sRNA‐dependent regulation of translation and stability of mRNA targets. While some ceRNAs seem to be expressed constitutively, others are intricately regulated according to environmental conditions. The outcome of ceRNA binding to a sRNA reaches beyond simple sequestration. Various effects observed on sRNA functions extend from reducing transcriptional noise to promote RNA turnover. Here, we present a historical perspective of the discovery of ceRNAs in eukaryotic organisms and mainly focus on the synthesis and function of select, well‐described, ceRNAs in bacterial cells.This article is categorized under:

RNA Interactions with Proteins and Other Molecules > Small Molecule–RNA Interactions
Translation > Translation Regulation
RNA Turnover and Surveillance > Regulation of RNA Stability
The scattering waves from an object in an elastic‐fluid layered structure
Authors: Elmorabie Khaled M. , Yahya Rania R. 
Published: February 2019

AbstractIn this work, we have investigated the scattered elastic waves from an object in a system consisting of an elastic layer above a fluid half‐space. A time‐harmonic load is applied upon the upper boundary surface, while the object is free of stresses. By constructing the corresponding Green's functions, a coupled system of boundary integral equations (BIE) over the contour of the object is formulated. The scattered waves are obtained by using the collocation technique which reduced the BIE to a system of linear algebraic equations. The results are compared with the case without the fluid to show the influence of the fluid pressure on the scattered waves. Numerical examples are carried to demonstrate the scattered waves from an object in different geometrical shapes.
Forensic genetic analysis of population of Madhya Pradesh with PowerPlex Fusion 6C™ Multiplex System
Authors: Dixit Shivani , Shrivastava Pankaj , Kumawat R. K. , Kaitholia Kamlesh , Dash Hirak Ranjan , Sharma Harsh , Choubey Gyaneshwer 
Published: February 2019

AbstractPerformance of PowerPlex Fusion 6C kit (PP F6C) was assessed in 374 unrelated individuals belonging to Madhya Pradesh, an Indian state. The study evaluated the forensic parameters for the loci included in PP F6C Multiplex System. The combined discrimination power (CPD) and combined exclusion power (CPE) were 1 and 0.999999995, respectively, for all 23 autosomal STR loci. SE33 showed the greatest power of discrimination (0.990) in the studied population, whereas TPOX showed the lowest (0.843). The availability of three Y-STR loci in the Multiplex System is suitable for assessing male contribution and amelogenin deletion in a single Multiplex PCR simultaneously. The study also presents the first global report on polymorphism in the Indian population on SE 33 autosomal STR loci and PP Fusion 6C Multiplex System. The results revealed that the studied STR Multiplex System is highly polymorphic and suitable for forensic purposes.
The functional impact of G protein-coupled receptor 142 (Gpr142) on pancreatic β-cell in rodent
Authors: Al-Amily Israa Mohammad , Dunér Pontus , Groop Leif , Salehi Albert 
Published: February 2019

Abstract
We have recently shown that the G protein-coupled receptor 142 (GPR142) is expressed in both rodent and human pancreatic β-cells. Herein, we investigated the cellular distribution of GPR142 within islets and the effects of selective agonists of GPR142 on glucose-stimulated insulin secretion (GSIS) in the mouse islets and INS-1832/13 cells. Double-immunostaining revealed that GPR142 immunoreactivity in islets mainly occurs in insulin-positive cells. Potentiation of GSIS by GPR142 activation was accompanied by increased cAMP content in INS-1832/13 cells. PKA/Epac inhibition markedly suppressed the effect of GPR142 activation on insulin release. Gpr142 knockdown (Gpr142-KD) in islets was accompanied by elevated release of MCP-1, IFNγ, and TNFα during culture period and abolished the modulatory effect of GPR142 activation on the GSIS. Gpr142-KD had no effect on Ffar1, Ffar2, or Ffar3 mRNA while reducing Gpr56 and increasing Tlr5 and Tlr7 mRNA expression. Gpr142-KD was associated with an increased expression of Chrebp, Txnip, RhoA, and mitochondrial Vdac1 concomitant with a reduced Pdx1, Pax6, and mitochondrial Vdac2 mRNA levels. Long-term exposure of INS-1832/13 cells to hyperglycemia reduced Gpr142 and Vdac2 while increased Chrebp, Txnip, and Vdac1 mRNA expression. GPR142 agonists or Bt2-cAMP counteracted this effect. Glucotoxicity-induced decrease of cell viability in Gpr142-KD INS-1 cells was not affected by GPR142-agonists while Bt2-cAMP prevented it. The results show the importance of Gpr142 in the maintenance of pancreatic β-cell function in rodents and that GPR142 agonists potentiate GSIS by an action, which most likely is due to increased cellular generation of second messenger molecule cAMP.
Presence and influence in lobbying: Evidence from Dodd-Frank
Authors: Ban Pamela , You Hye Young 
Published: February 2019

AbstractInterest groups face many choices when lobbying: when, who, and how to lobby. We study interest group lobbying across two stages of regulatory policymaking: the congressional and agency rulemaking stages. We investigate how the Securities and Exchange Commission responds to interest groups at the end of these stages using a new, comprehensive lobbying dataset on the Dodd-Frank Act. Our approach examines citations in the SEC's final rules which reference and acknowledge the lobbying activities of specific interest groups. We find that more than 2,900 organizations engaged in different types of lobbying activities either during the congressional bill stage, the agency rulemaking stage, or both. Meetings with the SEC and hiring former SEC employees are strongly associated with the citation of an organization in a final rule. Comments submitted by trade associations and members of Congress are cited more in a final rule compared to other organizations. While there is more variety in the types of organizations who lobby the bureaucracy than those who lobby Congress, presence does not necessarily lead to recognition or influence.
Certifying Private Security Companies: Effectively Ensuring the Corporate Responsibility to Respect Human Rights?
Authors: MACLEOD Sorcha , DEWINTER-SCHMITT Rebecca 
Published: February 2019

AbstractThe key purpose of this article is to critically assess the extent to which auditing and certification to quality assurance and risk management standards containing human rights-related requirements are an adequate and effective means of ensuring that private security companies internalize their responsibility to respect human rights. Based on participant observation, interviews and publicly accessible data, it concludes that in the absence of the adoption of specific assurance measures in the certification and oversight processes, the constructivist ‘tipping point’ resulting in the internalization of the corporate responsibility to respect may not be attained when there is inadequate norm compliance or, worse yet, norm regression.
Conics and a generalised conical pendulum
Authors: Daners Daniel , Wigmore Theresa 
Published: February 2019

There is a long tradition of using geometry to solve problems from mechanics. Unfortunately this tradition is not practised much in schools and university any more.With this exposition we would like to demonstrate how elementary properties of ellipses can be used to solve a problem related to the conical pendulum. The problem of the conical pendulum is to consider a mass attached to one end of a light inextensible string of length with the other end attached at the top of a vertical rod. The mass is moving about the rod in uniform circular motion in a horizontal plane. Given the angular velocity of the mass, the question is to determine the angle the string makes with the rod.
In-stream wetland deposits, megadroughts, and cultural change in the northern Atacama Desert, Chile
Authors: Tully Craig D. , Rech Jason A. , Workman T. Race , Santoro Calogero M. , Capriles José M. , Gayo Eugenia M. , Latorre Claudio 
Published: February 2019

AbstractA key concern regarding current and future climate change is the possibility of sustained droughts that can have profound impacts on societies. As such, multiple paleoclimatic proxies are needed to identify megadroughts, the synoptic climatology responsible for these droughts, and their impacts on past and future societies. In the hyperarid Atacama Desert of northern Chile, many streams are characterized by perennial flow and support dense in-stream wetlands. These streams possess sequences of wetland deposits as fluvial terraces that record past changes in the water table. We mapped and radiocarbon dated a well-preserved sequence of in-stream wetland deposits along a 4.3-km reach of the Río San Salvador in the Calama basin to determine the relationship between regional climate change and the incision of in-stream wetlands. The Río San Salvador supported dense wetlands from 11.1 to 9.8, 6.4 to 3.5, 2.8 to 1.3, and 1.0 to 0.5 ka and incised at the end of each of these intervals. Comparison with other in-stream wetland sequences in the Atacama Desert, and with regional paleoclimatic archives, indicates that in-stream wetlands responded similarly to climatic changes by incising during periods of extended drought at ~9.8, 3.5, 1.3, and 0.5 ka.
Reduction of the statistical error in electromagnetic gyrokinetic particle-in-cell simulations
Authors: Hatzky R. , Kleiber R. , Könies A. , Mishchenko A. , Borchardt M. , Bottino A. , Sonnendrücker E. 
Published: February 2019

The $\unicode[STIX]{x1D6FF}f$-PIC method is widely used for electrostatic particle-in-cell (PIC) simulations. Its basic idea is the ansatz $f=f_{0}+\unicode[STIX]{x1D6FF}f$ ($\unicode[STIX]{x1D6FF}f$-ansatz) where the particle distribution function $f$ is split into a usually time-independent background $f_{0}$ and a time-dependent perturbation $\unicode[STIX]{x1D6FF}f$. In principle, it can also be used for electromagnetic gyrokinetic PIC simulations, but the required number of markers can be so large that PIC simulations become impractical. The reason is a decreasing efficiency of the $\unicode[STIX]{x1D6FF}f$-ansatz for the so-called ‘Hamiltonian formulation’ using $p_{\Vert }$ as a dynamic variable. As a result, the density and current moment of the distribution function develop large statistical errors. To overcome this obstacle we propose to solve the potential equations in the symplectic formulation using $v_{\Vert }$ as a dynamic variable. The distribution function itself is still evolved in the Hamiltonian formulation which is better suited for the numerical integration of the parallel dynamics. The contributions from the full Jacobian of phase space, a finite velocity sphere of the simulation domain and a shifted Maxwellian as a background are considered. Special care has been taken at the discretisation level to make damped magnetohydrodynamics (MHD) mode simulations within a realistic gyrokinetic model feasible. This includes devices like e.g. large tokamaks with a small aspect ratio.
Of Gypsy Barons and the Power of Love: Operetta Programming and Popularity in the Postwar Soviet Union
Authors: Tomoff Kiril 
Published: February 2019

AbstractThis article utilises a nearly unique collection of material (theatre box office data) and the reports of Soviet bureaucrats charged with overseeing musical theatre to analyse the programming and reception of operetta performed in the Soviet Union from 1945 to 1948, a period during which Soviet society shifted from world war to Cold War, and music, musical life and musical theatres underwent ideological scrutiny and endured intervention by the Communist Party’s Central Committee. It argues that although official programming and audience preferences were rarely in sync, their disjuncture followed a surprising pattern according to which Russian operetta-going audiences proved both more conservative and more patriotic than those responsible for the programming in operetta theatres. Marked differences between this Russian pattern and patterns observable in other republics – Ukraine gets particular attention – also attest to the diversity of taste and official ambitions for musical programming in the postwar Soviet Union.
Ivan Susaninby Catterino Cavos andA Life for the Tsarby Mikhail Glinka: Comparing the Incomparable
Authors: Giust Anna 
Published: February 2019

AbstractThe myth of Mikhail Glinka still divides the history of Russian music, to the point that any influence on the creation of Russian opera before him is considered part of ‘prehistory’ in artistic terms. This is certainly true for the works of Catterino Cavos, a Venetian composer who made his career as a music director at the St Petersburg Imperial Theatres. The main purpose of this article is to compare Cavos’s operaIvan Susanin(1815) with Glinka’sA Life for the Tsar(1836), in order to highlight aspects of continuity in the process of creating the Russian operatic tradition. In this analysis, both Western and Russian traditions will be taken into consideration, which will enable a better assessment of Cavos’s contribution to the evolution of Russian music within a European frame.
The monumental landscape from below: public statues, popular interaction and nationalism in late nineteenth-century Amsterdam
Authors: PETTERSON ANNE 
Published: February 2019

ABSTRACT:Public monuments are considered an important tool in the nineteenth-century nation-building project. Yet while the intended (nationalist) message of the monumental landscape is often clear, the popular perception of the statues and memorials has been little problematized. This contribution analyses the popular interaction with public monuments in late nineteenth-century Amsterdam and questions whether ordinary people understood the nationalist meaning. With the help of visual sources – engravings, lithographs and the novel medium of photography – we become aware of the multilayered meanings and usages of the monuments in daily urban life, thus tackling the methodological challenge of studying the monumental landscape from below.
Paramedic and Emergency Medical Technician Reflections on the Ongoing Impact of the 9/11 Terrorist Attacks
Authors: Smith Erin C. , Burkle Frederick M. 
Published: February 2019

AbstractIntroductionIn the years following the September 11, 2001 terrorist attacks in New York City (New York USA), otherwise known as 9/11, first responders began experiencing a range of health and psychosocial impacts. Publications documenting these largely focus on firefighters. This research explores paramedic and emergency medical technician (EMT) reflections on the long-term impact of responding to the 9/11 terrorist attacks.MethodsQualitative methods were used to conduct interviews with 54 paramedics and EMTs on the 15-year anniversary of 9/11.ResultsResearch participants reported a range of long-term psychosocial issues including posttraumatic stress disorder (PTSD), anxiety, depression, insomnia, relationship breakdowns and impact on family support systems, and addictive and risk-taking behaviors. Ongoing physical health issues included respiratory disorders, eye problems, and cancers.DiscussionThese findings will go some way to filling the current gap in the 9/11 evidence-base regarding the understanding of the long-term impact on paramedics and EMTs. The testimony of this qualitative research is to ensure that an important voice is not lost, and that the deeply personal and richly descriptive experiences of the 9/11 paramedics and EMTs are not forgotten.SmithEC,BurkleFMJr.Paramedic and emergency medical technician reflections on the ongoing impact of the 9/11 terrorist attacks.Prehosp Disaster Med.2019;34(1):56–61.