bluuebunny/crossref_metadata_2025_split huggingface dataset:
‘THE BRIGHT PLACES OF LIFE AS CLEARLY AS THE DARK’: THE MUSIC OF LINDA BUCKLEY
Authors: Fox Christopher 
Published: March 2018

AbstractLinda Buckley is one of the leading figures in the thriving Irish new music scene, a composer whose work draws together many different elements, from spectralism, to ambient electronica, to minimalism and Irish traditional music. This article uses five works created in the last decade as lenses through which to examine a creative practice in which these apparently disparate elements have become increasingly integrated. From the 2008 string trio, Fiol, to the orchestral work Chiyo (2011), to Torann for large ensemble and electronics (2015), and finally to two works with string quartet, ó íochtar mara (2015) and Haza (2016), these works represent stages within the evolution of a highly distinctive musical language.
REFRAMING THE LISTENING EXPERIENCE THROUGH THE PROJECTED SCORE
Authors: Kim-Boyle David 
Published: March 2018

ABSTRACTOver the past ten years, performance scores have been radically foregrounded in a variety of performance practices. Whether such notations assume a prescriptive function, visually projected for musicians to interpret, or a descriptive one, unfolding as a documentation of a live coding performance, how might such a foregrounding reframe the listening process for an audience? Does a notational schema help promote a deeper, structural level understanding of a musical work? This article will consider these various questions, exploring how principles of graphic design and the transparency of notation contribute to the listening experience. It will suggest that works featuring projected scores find aesthetic value in the juxtaposition of notation's traditionally mnemonic function and the unique temporal modalities that projected scores establish.
Impact of medication on protein and amino acid metabolism in the elderly: the sulfur amino acid and paracetamol case
Authors: Mast Carole , Dardevet Dominique , Papet Isabelle 
Published: March 2018

AbstractThe optimisation of nutritional support for the growing number of older individuals does not usually take into account medication. Paracetamol (acetaminophen; APAP) is the first intention treatment of chronic pain that is highly prevalent and persistent in the elderly. Detoxification of APAP occurs in the liver and utilises sulfate and glutathione (GSH), both of which are issued from cysteine (Cys), a conditionally indispensable amino acid. The detoxification-induced siphoning of Cys could reduce the availability of Cys for skeletal muscle. Consequently, APAP could worsen sarcopenia, an important component of the frailty syndrome leading to dependency. The present review provides the rationale for the potential pro-sarcopenic effect of APAP then recent results concerning the effect of chronic APAP treatment on muscle mass and metabolism are discussed. The principal findings are that chronic treatments with doses of APAP comparable with the maximum posology for humans can increase the requirement for sulfur amino acids (SAA), reduce Cys availability for muscle, reduce muscle protein synthesis and aggravate sarcopenia in animals. One clinical study is in favour of an enhanced SAA requirement in the older individual under chronic treatment with APAP. Few clinical studies investigated the effect of chronic treatment with APAP combined with exercise, in nutritional conditions that probably did not affect Cys and GSH homeostasis. Whether APAP can aggravate sarcopenia in older individuals with low protein intake remains to be tested. If true, nutritional strategies based on enhancing Cys supply could be of prime interest to cut down the pro-sarcopenic effect of chronic treatment with APAP.
Church Planting and the Parish in Durham Diocese, 1970–1990: Church Growth Controversies in Recent Historical Perspective
Authors: Lockley Philip 
Published: March 2018

AbstractThis article unearths the forgotten history of the first modern church planting scheme in the Church of England: an attempt to restructure parish ministry in Chester-le-Street, near Durham, in the 1970s and 1980s. This story of rapid growth followed by decline, and of an evangelical church’s strained relations with their liberal bishop, David Jenkins, has pertinence for contemporary Anglican antagonisms over ‘fresh expressions’ and other church planting programmes. A culture of mistrust is arguably apparent both then and now, between liberals and conservatives in ecclesiology, even as the same line divides those of the reverse tendency in broader, doctrinal theology: conservatives from liberals. Developments, decisions and, indeed, debacles in the story of Chester-le-Street parish point to the urgent need for liberals and conservatives in Anglican ecclesiology and theology to overcome their mistrust of each other by recognizing the other as valuable for the mutual strengthening and renewal of the Church.
Bio-ionic Liquids as Adjuvants for Sulfonylurea Herbicides
Authors: Marcinkowska Katarzyna , Praczyk Tadeusz , Łęgosz Bartosz , Biedziak Agnieszka , Pernak Juliusz 
Published: March 2018

AbstractFive bio-ionic liquids (BILs) with choline cations and fatty acid anions derived from pelargonic acid, glycerol tristearate, glycerol trioleate, canola oil, and coconut oil were synthesized and applied as spray adjuvants with three sulfonylurea herbicides: metsulfuron-methyl, iodosulfuron-methyl-sodium, and tribenuron-methyl. Physicochemical properties, including thermal stability, solubility, and surface activity, were determined, and the influence of these BILs on herbicidal efficacy was studied in greenhouse tests using four target weed species: common lambsquarters (Chenopodium album L.), cornflower (Centaurea cyanus L.), corn poppy (Papaver rhoeas L.), and oilseed rape (Brassica napus L.). BILs, particularly those with the oleic anion and anions derived from canola oil and coconut oil, greatly improved herbicidal activity. Addition of BILs to the spray solution significantly reduced the surface tension and contact angle of spray droplets and increased the area of herbicide deposit on the leaf surface.
DASH, the data and specimen hub of the National Institute of Child Health and Human Development
Authors: Hazra Rohan , Tenney Susan , Shlionskaya Alexandra , Samavedam Rajni , Baxter Kristin , Ilekis John , Weck Jennifer , Willinger Marian , Grave Gilman , Tsilou Katerina , Songco David 
Published: March 2018

AbstractThe benefits of data sharing are well-established and an increasing number of policies require that data be shared upon publication of the main study findings. As data sharing becomes the new norm, there is a heightened need for additional resources to drive efficient data reuse. This article describes the development and implementation of the Data and Specimen Hub (DASH) by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) to promote data sharing from NICHD-funded studies and enable researchers to comply with NIH data sharing policies. DASH’s flexible architecture is designed to archive diverse data types and formats from NICHD’s broad scientific portfolio in a manner that promotes FAIR data sharing principles. Performance of DASH over two years since launch is promising: the number of available studies and data requests are growing; three manuscripts have been published from data reanalysis, all within two years of access. Critical success factors included NICHD leadership commitment, stakeholder engagement and close coordination between the governance body and technical team.
Editorial
Authors: Bantleon Hans-Peter 
Published: March 2018

Liebe Kolleginnen und Kollegen,In unserer schnelllebigen Zeit suchen wir immer nach Neuem und vergessen sehr oft, dass alte Konzepte sehr oft bessere Ergebnisse bringen. In dieser Ausgabe wird von Ute und Lorenz Moser das Behandlungskonzept der gesteuerten Extraktion vorgestellt und die notwendigen Voraussetzungen und Schritte diskutiert. Georg Strbac und Michael Nemez stellen eine innovative Methode zur Autotransplantation von Zähnen vor.
Effekt eines Rumpfkräftigungsprogramms (inklusive Unterarm- und seitlichem Unterarmstütz) auf die Verletzungsrate von erwachsenen Fußballspielern: eine systematische Literaturübersicht
Authors: Blasimann Angela , Eberle Simon , Scuderi Manuel 
Published: March 2018

Zusammenfassung
Hintergrund Fußball gilt als hochintensive Sportart mit einer erhöhten Verletzungsrate. Erwachsene Männer zeigen dabei die größte Verletzungsrate. Aktuell stellt die Kräftigung des Rumpfes einen wichtigen Bestandteil verschiedener Präventionsprogramme dar, wie beispielsweise beim „FIFA 11 +“. Das Ziel dieser Übersichtsarbeit bestand darin, herauszufinden, welchen Effekt ein Rumpfkrafttraining, mindestens bestehend aus den bekannten und einfach durchzuführenden Übungen Unterarmstütz und seitlicher Unterarmstütz, auf die Verletzungsrate bei erwachsenen Fußballspielern hat.
Probanden, Material und Methoden Die systematische Literatursuche erfolgte in den Datenbanken PubMed, PEDro, Cochrane Library, SPORTDiscus und Cinahl. Die Interventionsgruppe musste ein Training der Rumpfmuskulatur (als Teil eines Präventionsprogramms) bei erwachsenen Fußballspielern beinhalten, die Kontrollgruppe ihre gewohnten Trainingseinheiten weiterführen. Der Unterarmstütz wie auch der seitliche Unterarmstütz mussten in der Interventionsgruppe angewendet werden. Als Outcome wurde die Anzahl von Verletzungen und/oder die Verletzungshäufigkeit (pro 1000 h Training und Match) definiert. Die Qualität der Studien wurde mittels der PEDro-Skala und des Risk-of-Bias-Tool beurteilt.
Ergebnisse Total wurden sieben Studien mit insgesamt 2491 Probanden eingeschlossen. In drei Studien fand eine signifikante Abnahme der Verletzungsrate in der Interventionsgruppe statt (p < 0,05 bzw. p < 0,001). Bei zwei weiteren Studien wurde kein Signifikanzniveau bestimmt oder angegeben. Sie zeigten aber ebenfalls präventive Effekte in der Interventionsgruppe. In den anderen drei Studien wurde keine signifikante Veränderung der Verletzungsrate festgestellt (p > 0,05).
Schlussfolgerung Die sieben Forschungsarbeiten unterschieden sich stark in Bezug auf die Methodik, die Intervention und die Ergebnisse. Zudem wurde der Rumpf nie isoliert, sondern immer als Teil eines Programmes mit weiteren präventiven Maßnahmen, trainiert. Dadurch war ein Vergleich der Studien schwierig. Trotzdem waren Tendenzen zu erkennen, dass sich ein Präventionsprogramm mit Übungen zur Kräftigung der Rumpfmuskulatur positiv auf die Verletzungsrate auswirkt. Aufgrund der aktuellen Studienlage kann die Fragestellung jedoch nicht abschließend beantwortet werden. Es bedarf weiterer Studien, die den Effekt eines isolierten Rumpfkrafttrainings auf die Verletzungsrate bei Fußballspielern untersuchen.
The Evaluation of the Awareness, Attitude and Practice of the Elderly Toward Self-Medication: A Cross-Sectional Study
Authors: Heidari Mohammad , Borujeni Mansureh , Ghafourifard Mansour , Sheikhi Rahim 
Published: March 2018

Abstract
Introduction The prevalence of various diseases in the elderly has increased the use of drugs, which is coupled with age-related physiological changes and places the elderly at risk for multiple side effects. The present study aimed to determine awareness, attitudes and practices of elderly towards self-medication.
Materials and Methods The sample included 300 participants over 60 years under any of the health centers in urban and rural areas of Abadeh city, who were selected based on stratified random sampling method. In order to collect data, the questionnaire including demographic information, awareness, attitude and performance of the elderly and the checklist of drug intractable consumption.
Results Based on the results, 76% of the elderly reported drug consumption. Regarding lifestyle, the average score of the elderly’s awareness for the elderly who lived with and without families were 78.6±14.2 and 69.2±13.6, respectively. In other words, a significant difference was observed between these two groups. In addition, there was a significant between the elderly’s performance score with and without family members about the self-medication (p=0.001).
Conclusion Considering the increase in self-medication among the elderly, adherence to prescription criteria for drug among this age group is recommended. Finally, designing and implementing various educational programs in health education center is necessary for the elderly and their families for the purpose of improving awareness and practice.
Procoagulant Microparticles: New Insights and Opportunities in Pregnancy Loss?
Authors: Greer Ian 
Published: March 2018

SummaryIn recent years, prothrombotic states have been not only associated with an increased risk of venous thrombosis, but also with pregnancy complications. In particular there is good evidence linking antiphospholipid antibody syndrome, which is associated with increased thrombin generation (1), to recurrent miscarriage. The importance of procoagulant changes in the pathophysiology of recurrent miscarriage is emphasised by the fact that treatment with heparin and low dose aspirin will substantially improve the likelihood of a successful pregnancy (2). Essentially, this is the only successful medical intervention in the treatment of miscarriage. There are also data now accumulating that link congenital thrombophilia to pregnancy complications such as miscarriage, pre-eclampsia, intra-uterine growth restriction, abruption and intrauterine death (3, 4). Furthermore, recent data have shown that acquired changes in the coagulation system, such as the acquired activated protein C resistance of pregnancy is also associated with an increased risk of pre-eclampsia (5). These data collectively suggest that procoagulant changes in general, rather than congenital or acquired thrombophilia in particular are associated with the development of pregnancy complications including fetal loss. However, in the majority of cases of fetal loss no cause is found and we cannot easily link these events to a procoagulant problem in the mother. In this issue of the Thrombosis and Haemostasis, Laude et al. (6) report, for the first time, the association between circulating procoagulant microparticles and pregnancy loss so providing a new insight into potential mechanisms.
The Glasgow Outcome, APCR and Lipid (GOAL) Pregnancy Study: Significance of Pregnancy Associated Activated Protein C Resistance
Authors: Sattar Naveed , Walker Isobel , Greer Ian , Clark Peter 
Published: March 2018

SummaryActivated protein C (APC) resistance secondary to Factor V Leiden (FVL) is associated with pregnancy failure and pre-eclampsia (PET). In non-pregnant subjects, the degree of resistance to APC relates to venous thrombosis risk. In pregnancy, resistance to APC occurs in the absence of FVL. We investigated, in an unselected prospective longitudinal study of 1671 pregnant, non-FVL subjects, the relationship of the APC sensitivity ratio (APC:SR) with demographic variables and pregnancy outcome.Lower APC:SR values at 7-16 weeks gestation were observed in subjects who subsequently developed PET (median APC:SR 2.55, IQR 2.29-2.70 vs 2.69, IQR 2.48-2.93, Mann-Whitney U-test p = 0.003) in the current pregnancy. An APC:SR < the median (2.69) at 7-16 weeks was associated with a 2.95-fold increased risk (CI95 1.2-7.4) of PET in the current pregnancy. No relationship between the APC:SR, at any gestation, and fetal loss was observed. An inverse correlation between the APC:SR and birth weight was noted. Higher APC:SRs were observed in blood group O subjects and smokers. An inverse relationship of the APC:SR with age, diastolic blood pressure and total serum cholesterol was observed.
Structural and Functional Characteristics of the B-domain-deleted Recombinant Factor VIII Protein, r-VIII SQ
Authors: Almstedt Annelie , Brandt Jörgen , Gray Eva , Holmquist Leif , Oswaldsson Ulla , Sebring Stefan , Mikaelsson Marianne , Sandberg Helena 
Published: March 2018

SummaryRecombinant factor VIII SQ (r-VIII SQ), ReFacto®, is a recombinant factor VIII product similar to the smallest active factor VIII protein found in plasma-derived factor VIII (p-VIII) concentrates. The protein comprises two polypeptide chains of 80 and 90 kDa and lacks the major part of the heavily glycosylated B-domain i.e. amino acids Gln744 to Ser1637. r-VIII SQ retains six potential glycosylation sites for N-linked oligosaccharides at asparagine residues 41, 239, 582, 1685, 1810 and 2118.We describe a thorough comparison of the characteristics of r-VIII SQ with those of p-VIII. The primary and secondary structures of r-VIII SQ were in good agreement with that of B-domain-deleted p-VIII (p-VIII-LMW) as shown by SDS-PAGE, Western blotting with antifactor VIII antibodies, tryptic mapping, amino acid sequence analysis and circular dichroism spectroscopy. A few divergences also existed. Thus r-VIII SQ was shown to contain a small amount of the single chain primary translation product of 170 kDa and also the product specific sequence of 14 amino acids, the SQ-link, in the C-terminal end of the 90 kDa chain. It was shown that r-VIII SQ had a high specific activity of about 14,000 IU VIII:C/mg as determined by use of a chromogenic substrate assay. The r-VIII SQ protein was comparable to p-VIII forms with a retained B-domain, in terms of potency measured by a chromogenic substrate or a two-stage clotting assay, in interactions with thrombin, and with activated protein C (APC) in combination with Protein S. The ability of r-VIII SQ to participate as a cofactor in factor Xa generation in a mixture of factors IXa and X, phospholipid and calcium was in conformity with that of p-VIII. Furthermore r-VIII SQ had a good binding capacity for phospholipid vesicles and von Willebrand factor (vWF) as shown in gel filtration studies. The same kinetics in binding to von Willebrand factor was found for r-VIII SQ and p-VIII as determined by real-time biospecific interaction analysis (BIA) with use of the BIAcore® instrument. The apparent association rate constant was 4 × 106 M−1s−1. Two dissociation rate constants were found, 1 × 10−2s−1 and 4 × 10−4s−1. The results extend the present knowledge that the factor VIII B-domain is dispensable for the factor VIII cofactor function in hemostasis.
Molecular Mechanism of Type I Congenital Heparin Cofactor (HC) II Deficiency Caused by a Missense Mutation at Reactive P2 Site: HC II Tokushima
Authors: Kanagawa Yasuhiko , Shigekiyo Toshio , Aihara Ken-ichi , Akaike Masashi , Matsumoto Toshio , Azuma Hiroyuki 
Published: March 2018

SummaryWe found a 66-year-old Japanese patient with type I congenital heparin cofactor (HC) II deficiency manifesting multiple atherosclerotic lesions. To investigate the molecular pathogenesis of our patient, we performed sequencing analysis and expressed recombinant human wild-type and mutant HC II molecules in COS-1 and CHO-K1 cells. Sequencing analysis following amplification of each of all 5 exons and its flanking region showed a single C to T transition at nucleotide position 12,854 in exon 5, which changed a Pro443 codon (CCG) to Leu codon (CTG). Because this mutation generates a new Bbv I site, the Bbv I digestion pattern of the PCR-amplified exon 5 fragments from each family member was analyzed. In all cases, the patterns were consistent with the activities and antigen levels of plasma HC II in those members. Transient transfection, metabolic labeling and pulse-chase experiments followed by immunoprecipitation analysis showed that the recombinant mutant HC II molecules were secreted from COS-1 cells in reduced amounts compared with the wild-type, and that an enhanced intracellular association of the mutant molecules with a chaperone, GRP78/BiP, was observed in CHO-K1 cells. Northern blot analysis indicated that the mutant HC II mRNA was transcribed at a similar level as that of wild-type.Immunohistochemical staining of the transfected cells revealed that COS-1 cells expressing the mutant HC II molecules were stained mainly in the perinuclear area. We conclude that the impaired secretion of the mutant HC II molecules, due to intracellular degradation, is the molecular pathogenesis of type I congenital HC II deficiency caused by a Pro443 to Leu mutation at reactive P2 site.
Antibodies to Factor XII Are Distinct from Antibodies to Prothrombin in Patients with the Anti-phospholipid Syndrome
Authors: Nicholls P. J. , Donohoe S. , Gallimore M. J. , Winter M. , Jones D. W. 
Published: March 2018

SummaryPatients with the anti-phospholipid syndrome (APS) have antiphospholipid antibodies (aPA) which are often targeted towards phospholipid binding proteins such as β2-glycoprotein I and prothrombin. Antibodies to factor XII (FXIIabs) have also been identified in some patients with APS. Factor XII (FXII) is a member of the kringle family of proteins which include plasminogen and prothrombin. Antibodies to prothrombin have been associated with myocardial infarction and have been shown to cross react with plasminogen.Sixteen patients with APS and FXIIabs were investigated for the presence of antibodies to prothrombin, by enzyme linked immunosorbent assay in a calcium (Ca++) independent assay. All sixteen showed different antibody binding patterns than those observed for antibodies to FXII.Eight patients were further investigated using surface plasmon resonance (SPR) for antibody binding to covalently bound FXII and to covalently bound prothrombin in both Ca++ dependent and independent systems. Of three patients demonstrating antibody binding to FXII by SPR, none demonstrated antibody binding to prothrombin in a Ca++ independent system with one demonstrating antibody binding to prothrombin that was Ca++ dependent. Of five patients who did not bind FXII by SPR, one demonstrated antibody binding to prothrombin in a Ca++ independent system while two demonstrated antibody binding to prothrombin in a Ca++ dependent system. Antibodies to FXII in patients with APS appear to be distinct from antibodies to prothrombin.
Factor VII Activation, Apolipoprotein A-I and Reverse Cholesterol Transport: Possible Relevance for Postprandial Lipaemia
Authors: Cooke C. J. , Nanjee M. N. , Howarth D. J. , Cooper J. A. , Stepanova I. P. , Morrissey J. H. , Miller N. E. , Miller G. J. 
Published: March 2018

SummaryPostprandial lipaemia is associated with activation of factor VII (FVII) and efflux of cholesterol from tissues to nascent plasma high density lipoproteins (HDL) containing apolipoprotein A-I (apo A-I). To determine whether FVII activation and cholesterol efflux occur together in other situations, the responses to intravenous infusion of HDL-like apo A-I/phosphatidylcholine discs were measured in 10 healthy men. Disc infusion (40 mg apo A-I/kg body weight) over 4 h was followed by increases in HDL cholesteryl ester and plasma apo A-I (p <0.0001). Significant activation of FVII was apparent during infusion in fasting subjects (p = 0.03), activated FVII averaging 123% of baseline value by 12 h (p <0.0001). Plasma thrombin-antithrombin (TAT) complex increased to 156% of baseline level by 12 h (p >0.05) but individual responses differed considerably. Peak TAT post-infusion was associated inversely with peak HDL triglyceride concentration (p = 0.004). The coagulation responses to disc-infusion may be due to transfer of phosphatidylserine to cell surfaces during cholesterol efflux.