bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Anturane Reinfarction Italian Study (Aris)
Authors: Polli E , Cortellaro M 
Published: July 2018

ARIS, which closed on Dec. 31, 1980, was a multicenter (26 centers coordinated by Medical Clinic I, Milan University), randomized, double-blind, placebo-controlled trial designed to assess the efficacy of sulfinpyrazone (S) (200 mg × 2 twice a day, dose reached gradually during the 1st week) in reducing cardiac mortality, non-fatal reinfarction and other major thromboembolic events (endpoints selected to evidence S’s antithrombotic effect) in patients (≤ 70 yr) with a documented myocardial infarction (MI). Enrollment was at 15-25 days after MI during hospitalization and follow-up was 1-3 yr. The population required (700 patients;α = 0.05, 1 -β = 0.90) was based on the assumption that the rate of endpoints would be about 20% in the mean observation period (2 yr) and that S would reduce this to 10%, considering also dropouts. All events were classified according to predetermined criteria. Interim history, physical examinations, laboratory tests and EOT were performed at various fixed times. Trial enrollment closed on Dec. 31, 1979 with a total of 727 patients. Statistical analysis will be performed according to life tables methods. Response time (period of time until a critical event) analysis will be done by Gehan’s and log-rank procedures and by a regression-life table technique (Cox).At Dec. 15, 1980, before the final blind revision, the following data are available: 41 total deaths; 37 deaths for cardiac causes; 42 non-fatal reinfarctions; 9 other thromboembolic events. This trial included a study of the trend of some hemostatic parameters.
Antiactivator (Antikinase) Activity of Human Plasma and Its Blocking by Parachloromercuribenzoate and Salicylate
Authors: Nanninga L. B , Guest M. M 
Published: July 2018

SummaryA two-stage assay for fibrinolytic antiactivator (FAA), independent of the concentration of antifibrinolysin (AFL) in plasma, is based upon the essentially complete precipitation of profibrinolysin (PFL) in euglobulin precipitated at pH 5.6. In the first stage a standardized amount of urokinase converts part or all of the PFL to fibrinolysin (FL) depending upon the concentration of FAA in the test plasma. FL and AFL remain in the supernatant solution during precipitation of the euglobulins. In stage two PFL from the euglobulin precipitate is completely activated by urokinase and the generated fibrinolytic activity is estimated from turbidity measurements of the fibrinogen remaining after a standardized incubation period.FAA is strongly blocked by parachloromercuribenzoate and more weakly blocked by salicylate. The dissociation constant of the UK-FAA complex is estimated to be 2 × 10∼9M. The FAA in plasma can block 5600 CTA units UK/ml plasma (1.1 x 10∼6M). For UK concentrations much lower than 9.5 U/ml (2 × 10-9 M), it was calculated that 590 u UK are bound per ml for every unit free UK/ml. At 37 ° C the kinetic constant of PFL activation by UK is 1.25 × 105 sec-1 M-1.
Virus Infection and Blood Coagulation
Authors: Gagel Ch , Linder M , Müller-Berghaus G , Lasch H. G 
Published: July 2018

SummaryBy means of a new model, the fowl plague of chickens, further evidence is given that viruses may trigger blood coagulation. Macroscopically, hemorrhages were observed, whereas microscopic studies revealed platelet and fibrin thrombi in the small vessels of various organs. Hematologic studies demonstrated an increase in the clotting time and a decrease in the activities of clotting factors I, II, VIII and X, and drop in platelet counts. Heparin could diminish the hemorrhages but did not influence the survival time of the animals.
Defective Collagen-Induced Platelet Aggregation in a Normal Population
Authors: ten Cate J. W , de Vries S. I , Sixma J. J , van Berkel W 
Published: July 2018

SummarySystemic studies on platelet functions of normal healthy individuals were carried out in two independent centres. Both samples of 40 volunteers comprised several individuals (Amsterdam 3 and Utrecht 5 individuals) with a syndrome consisting of an absent collagen-induced platelet aggregation, a reversible ADP-aggregation and frequently a decreased platelet retention in the glass bead column. Occasionally the platelet factor-3 availability was decreased.
Platelet Aggregation and Platelet Factor 3 Activity in Myeloproliferative Disorders
Authors: Tangün Y 
Published: July 2018

Summary33 patients with myeloproliferative disorder were studied and in 28 (84%) various anomalies of platelet function were observed. Single, or more commonly, multiple platelet aggregation defects and impaired release of platelet ADP and platelet factor 3 activity were the chief anomalies noted, whether thrombocytosis was present or not. The effect of myelosuppressive therapy upon the defects demonstrated varied from patient to patient, and from one anomaly to another. Reducing the high platelet count to normal levels does not seem to be sufficient to eradicate qualitative platelet defects.
An Experimental Obliterating Thromboangiitis Limited to the Posterior Part of the Body*
Authors: Selye H , Nielsen K , Tuchweber Beatriz 
Published: July 2018

SummaryAfter a brief outline of the principles involved in the production of thrombo- hemorrhagic phenomena (THP) with special organotropic localizations, an experimental technique is described which permits the production of acrocyanosis and thrombohemorrhagic lesions largely limited to the posterior part of the body.This phenomenon can be consistently produced by certain combinations of THP elicitors, anaphylactoid agents and noradrenaline (NA). The most effective combination among those tested is thorium dextrin (Th-Din) plus tannic acid plus NA.Several drugs can decisively influence the course of this reaction. Most notable among these are Neo-Antergan (an antihistaminic) which sensitizes for the production of the aboral THP, while heparin (presumably through its anticoagulant effect) and Dibenamine (presumably through its antiadrenergic action) offer virtually complete protection.When only Th-Din plus tannic acid is given, there develops an intense but reversible cyanosis in the hind paws and tail; additional treatment with NA induces obliterating thromboangiitis with hemorrhages and gangrene. None of these changes are produced by Th-Din, tannic acid or NA alone. Evidently, here, we are dealing with pluricausal experimental diseases whose possible relationship to Raynaud’s disease, thromboangiitis obliterans and anaphylactoid purpura is briefly discussed.
The Action on Blood Clotting of Different Lipoid Fractions of Beef Brain* (Methods of Fractionization and Chromatographic Isolation Procedure of a Phospholipid Anticoagulant)
Authors: Kahn M. J. P , Hans M , Bourgain R. H 
Published: July 2018

SummaryA method of fractionation and isolation of a lipid anticoagulant from beef brain has been described. This method is based on chemical and chromatographic techniques. The lipid anticoagulant was found to be an inositol monophosphatide containing two different fatty acids. The anticoagulant activity has been evidenced in the Russell-viper-venom test and is believed to interfere with the formation of the early intermediate products involving factor X.
Über die Erhöhung des Antithrombin-Niveaus während Cumarin-Behandlung
Authors: Péter M 
Published: July 2018

ZusammenfassungDie thrombininaktivierende Fähigkeit des Serums, die Aktivität des Antithrombin III und des endogenen Heparins wurden vom Autor bei 70 mit Cumarin (Syncumar) behandelten Patienten mit der Gerendâsschen Methode bestimmt. Bei sämtlichen Fällen wurde eine Erhöhung der Thrombininaktivie- rung sowie der Antithrombin-III- und der Heparinaktivität konstatiert; es wurde auf die Abnahme des Prothrombinniveaus und die Zunahme der Antithrombine hingewiesen, zwischen denen zweifellos eine Korrelation besteht. Die im Laufe der Cumarin-Behandlung beobachtete Erhöhung der Thrombininakti- vierung kann mittels Heparin auch in vitro erzielt werden. Nicht nur im Serum sondern auch im Plasma der Cumarin-Behandelten sind die Antithrombinwerte in signifikanter Weise erhöht. Der Autor ist der Meinung, daß bei der Erhöhung des Antithrombinniveaus auch die sich unter Einwirkung des Cumarins verlangsamende latente Blutgerinnung eine Rolle spiele.
The Effect of Warfarin Sodium on the Duration of Platelet Aggregation
Authors: Knieriem H. J , Chandler A. B 
Published: July 2018

SummaryThe effect of the administration of warfarin sodium (Coumadin®) on the duration of platelet aggregation in vitro was studied. Coumadin was given for 4 consecutive days to 10 healthy adults who were followed over a period of 9 days. The duration of adenosine diphosphate-induced platelet aggregation in platelet-rich plasma, the prothrombin time, and the platelet count of platelet-rich plasma were measured. Four other healthy adults received placebos and participated in a double-blind study with those receiving Coumadin.Although administration of Coumadin caused a prolongation of the prothrombin time to 2 or 21/2 times the normal value, a decrease in the duration of platelet aggregation was not observed. In most individuals who received Coumadin an increase in the duration of platelet aggregation occurred. The effect of Coumadin on platelet aggregation was not consistently related to the prothrombin time or to the platelet count. In the placebo group there was a distinct relation between the duration of platelet aggregation and the platelet count in platelet-rich plasma.The mean increase in the duration of platelet aggregation when compared to the control value before medication with Coumadin was 37.7%. In the placebo group there was a mean increase of 8.4%. The difference between the two groups is significant (p <0.001). Increased duration of platelet aggregation also occurred in two individuals who received Coumadin over a period of 10 and 16 days respectively.
Peptidase Activity in Human Platelets
Authors: Kocholaty Walter ,   with technical assistance of Miss S. M. Horn
Published: July 2018

SummaryNormal human platelets contain a variety of di- and tripeptidases. The hydrolytic action of platelet extracts on glycylglycine, glycyl-L-leucine and L-leucylglycine was investigated under a variety of conditions. The pH optima, heavy metal activation and some other properties of these enzymes were described and compared with that of serum and the other formed elements of the blood.
Prevalencia de disfunción eréctil en hombres del Quindío, y factores de riesgo asociados
Authors: De La Hoz Franklin José Espitia 
Published: July 2018

Introducción La disfunción eréctil es la incapacidad persistente, de un hombre, para lograr o mantener una erección que le permita una relación sexual satisfactoria.
Objetivo Conocer la prevalencia de disfunción eréctil en una muestra de hombres del Quindío, y conocer los factores de riesgo relacionados con su aparición.
Materiales y Métodos Estudio descriptivo de corte transversal, en el período de enero de 2010 a diciembre de 2016. Muestra constituida por hombres de 18 a 87 años, los cuales asistieron como acompañantes de las mujeres que acudieron a la Clínica Sagrada Familia de Armenia. La disfunción eréctil se evaluó mediante el cuestionario: Índice Internacional de la Función Eréctil abreviado (IIEF-5).
Resultados Se encuestaron 1.902 hombres, con edad media de 48,6 ± 6,9 años. La media del puntaje en el IIFE-5 fue 17,58 ± 5,37 puntos (rango entre 6 y 25 puntos). La prevalencia de disfunción eréctil en la población general alcanzó un 47,63%, y en la edad o población productiva 39,1%. El 85,81% de los mayores de 50 años, tenían más disfunción eréctil, comparado con el 15,11% de los menores de 50 años (p < 0,0007). En cuanto a la intensidad de la disfunción eréctil, la más elevada es la severa (16,27%), la moderada 10,46%, y leve a moderada 12,79%. La prevalencia de la severa se incrementó en los mayores de 50 años (26,64%) en comparación con los menores de 50 años (1,92%), p = 0,0051. Entre las variables que aumentan el riesgo en este estudio, se destacan: enfermedades crónicas, prostatectomía, tabaquismo, obesidad, sedentarismo, edad superior a 50 años, etc.
Conclusiones Un significativo porcentaje de hombres del Quindío presenta un bajo puntaje en el IIFE-5, compatible con la disfunción eréctil; lo cual está asociado a múltiples factores de riesgo prevalentes en nuestra población.
Prostatitis: revisión de una patología enigmática y su relación con la fertilidad masculina
Authors: Puerta Suárez Jenniffer , Cardona Maya Walter 
Published: July 2018

Introducción La prostatitis, término que involucra cuatro categorías de inflamación de la próstata, es considerada una patología enigmática por su complejidad en el diagnóstico e involucra el uso indiscriminado de antibióticos sin obtener evidencia de la infección. El objetivo de esta revisión es describir una patología de mal diagnóstico y de gran magnitud sobre la fertilidad masculina.
Materiales y Métodos Se realizó una revisión de la literatura científica a conveniencia en la base de datos PubMed, empleando los términos prostatitis, prevalencia, dolor pélvico crónico y diagnóstico.
Resultados La prevalencia de prostatitis varía entre 1,8% y 65% en los estudios evaluados, la prevalencia depende de la metodología empleada y del tipo de población evaluada.
Conclusión Se requiere determinar la prevalencia de prostatitis en la población en general, con el fin de mejorar las ayudas diagnósticas y el tratamiento para evitar la propagación de microorganismos.
Síndromes de neoplasia endocrina múltiple: revisión radiológica
Authors: García Ignacio Martín , Tocino Rosario Vidal , García Elisabeth Martín , Pérez Manuel Ángel Martín , Balbín José Martín Marín 
Published: July 2018

ResumenLos síndromes de neoplasia endocrina múltiple (MEN), incluyen una serie de enfermedades con alteraciones genéticas que se caracterizan por la presencia de tumores que afectan a dos o más glándulas endocrinas. Son síndromes con una herencia autosómica dominante e incluyen tres patrones: MEN 1 (síndrome de Wermer), MEN 2 (que incluye MEN 2A o síndrome de Sipple y MEN 2B o síndrome de Wagenmann-Froboese) y MEN 4. Los adenomas paratiroideos y el carcinoma medular tiroideo, son los tumores más frecuentes del MEN tipo 1 y 2 respectivamente. Esos síndromes son más comunes en pacientes jóvenes, con patología de afectación bilateral, múltiple o multifocal y, sobre todo, en pacientes con antecedentes familiares. Es necesario el trabajo en equipo de endocrinólogos, cirujanos, oncólogos y radiólogos para optimizar el tratamiento de esos pacientes.
Laborkontrollen vor, während und nach einer Thrombolysetherapie im Kindesalter
Authors: Kehl H. G. , Vielhaber H. , Nowak-Göttl Ulrike 
Published: July 2018

ZusammenfassungThrombosen im Kindes- und Jugendalter sind ernst zu nehmende Ereignisse und erfordern neben einer Ursachenklärung eine adäquate Therapie. Bei den heute üblichen Lysetherapien im Kindesalter haben Laboranalysen neben der Überwachung der Antikoagulanzientherapie die wesentliche Aufgabe der Therapiesteuerung. Die Laboranalyse besteht vor Thrombolysetherapie in der Bestimmung von Thrombozytenzahl, Hämoglobin, TPZ, aPTT, Fibrinogen, Antithrombin, Plasminogen und D-Dimer. Während der Lysetherapie sollen zur Therapiesteuerung, zur Erfassung von möglichen Nebenwirkungen und Begleitantikoagulation Thrombozyten, Hämoglobin, aPTT, Antithrombin, Plasminogen und D-Dimer bestimmt werden. Zur Verhinderung einer Reokklusion unter voller Antikoagulation nach Thrombolyse besteht die Laborkontrolle in der Akutphase in der Analyse von aPTT, Antithrombin und D-Dimer.
Eröffnung von Verschlüssen der Arteria femoralis nach Herzkatheterisierung
Authors: Gildein P. , Mocellin R. , Sutor A. H. , Krüger M. 
Published: July 2018

ZusammenfassungDie Thrombosierung der Arteria femoralis nach retrograder Katheterunter-suchung stellt im Kindesalter die häufigste Indikation für den Einsatz einer syste-mischen Lysetherapie dar. Hierbei kommen heute Urokinase oder rt-PA zum Einsatz. Wir untersuchten retrospektiv alle Patienten mit Thrombose der Femo-ralarterie nach Katheteruntersuchung in den letzten 42 Monaten, um die Sicherheit und Effektivität des verwendeten Schemas einer Urokinaselyse (Bolus 10000 E/kg, Dauerinfusion 2500 E/kg, parallel Heparininfusion) zu überprüfen. In 42 Monaten wurden 82 Patienten unter 15 kg Körpergewicht arteriell femoral punktiert. Bei sieben Patienten (8,5%) wurde eine systemische Lyse durchge-führt. Bei allen Patienten kam es nach 23-132 h zur Wiedereröffnung des Ge-fäßes. Bei drei dieser Patienten kam es zum deutlichen Hämoglobinabfall aufgrund einer lokalen Nachblutung, die durch Kompression gut beherrschbar war. Andere Blutungskomplikationen fanden sich nicht. In keinem Fall war eine Bluttransfusion notwendig. Während die Lysetherapie mit rt-PA auch im Kindesalter wegen der thrombinspezifischeren Wirksamkeit zunehmende Verbreitung findet, zeigen unsere Ergebnisse bei den sieben Patienten eine gute und sichere Wirksamkeit der Urokinasetherapie.
Incidencia de hidronefrosis transitoria en reimplante vesicouretral abierto con técnica de Lich Gregoir en niños con reflujo vesicoureteral
Authors: Bolaños Andrea Patrica , Larios Carlos Alberto , Rodriguez Pablo Gonzalez , Franco Diana Carolina , Mora Jorge Andres , Quiroz Madarriaga Yesica Yasmín 
Published: July 2018

Resumen
Introducción y Objetivo La técnica de Lich Gregoir es actualmente la de elección para la corrección del reflujo vesicoureteral (RVU) de alto grado, con complicaciones como la obstrucción ureteral. La literatura reporta tasas del 6% al 28% de hidronefrosis transitoria, las cuales, en su gran mayoría, corresponden a un hallazgo temporal sin repercusión clínica. El objetivo de este trabajo es establecer la incidencia de hidronefrosis transitoria y la asociación con factores de riesgo.
Materiales y Metodos Realizamos una cohorte descriptiva retrospectiva, analizando 119 unidades ureterales reimplantadas mediante técnica de Lich Gregoir (LG) en menores de 18 años, entre Septiembre del 2009 y abril del 2017. Se excluyeron pacientes con megauréter primario, RVU secundario y cirugía previa para corrección de RVU. El análisis estadístico se realizó con Stata 13.0
Resultados Evaluamos 85 pacientes, 34 de ellos reimplantados de manera bilateral, para un total de 119 unidades ureterales. El promedio de edad fue de 4,4 años y el 68% fueron mujeres. El RVU grado IV fue el más prevalente con el 42%. Las ecografías renales prequirúrgicas fueron normales en el 63% de los casos y el 14,2% presentó hidronefrosis transitoria con resolución a los 3 meses. No se reportaron casos de obstrucción ureteral. El grado de reflujo prequirúrgico no se asoció con hidronefrosis transitoria (p = 0,64) así como tampoco la lateralidad (p = 0,06).
Conclusión El reimplante vesicoureteral abierto con técnica de Lich Gregoir en nuestra institución, reporta tasas de hidronefrosis transitoria comparables a la literatura mundial. No se identificaron factores de asociación para hidronefrosis transitoria, diferentes a la técnica quirúrgica perse.
Refinements in Saddle Nose Reconstruction
Authors: Chen Yung Yuan , Jang Yong Ju 
Published: July 2018

AbstractSaddle nose correction remains a challenging procedure for rhinoplasty surgeons due to both aesthetic and functional issues. The most common causes of saddle nose are nasal trauma and prior septal surgery, and a defective relationship between the caudal septum and the anterior septal spine is the principal postoperative pathology. The authors propose their own classification system for saddle nose with one new category and several approaches to deal with this condition in accordance with the level of severity. They strongly advocate major septal reconstruction for most cases of saddle nose, either by placing extended spreader grafts, caudal extension grafts, or a new extracorporeally made L strut. For extreme cases, integrated dorsal implant with columellar strut can successfully bypass the saddled nasal dorsum without dissecting the septal mucoperichondrial pocket and achieve adequate dorsal height. Further dorsal augmentation can be achieved by applying side/gap grafts or dorsal onlay grafts in different forms. In cases with retracted columella, a premaxillary plumping graft is another useful technique. Finally, in autoimmune-related saddling patients, the evidence indicates that their aesthetic problems can be managed safely with surgery as long as the disease is well under control.
The Emerging Importance of Liver Sinusoidal Endothelial Cells in Regulating Injury during Machine Perfusion of Deceased Liver Donors
Authors: Mergental Hynek , Mirza Darius , Afford Simon , Bhogal Ricky 
Published: July 2018

AbstractWhile majority of liver transplants worldwide continue to be performed using deceased donor organs, the demands for donor livers continues to exceed the current supply. In an attempt to maximize the number of potentially usable donor livers and expand the current donor pool, there is intense global research by various groups exploring the role of machine perfusion in the liver transplantation, particularly with respect to the machine perfusion of extended-criteria liver donors. In this review, the authors summarize the current field of machine perfusion strategies as applied to deceased donor liver transplantation and how therapeutic targeting of the liver sinusoidal endothelial cell may improve the quality of donor livers.
Enhancement of Tissue Plasminogen Activator-Catalyzed Plasminogen Activation by Escherichia coii S Fimbriae Associated with Neonatal Septicaemia and Meningitis
Authors: Parkkinen Jaakko , Hacker Jörg , Korhonen Timo K 
Published: July 2018

SummaryThe effect of Escherichia coli strains isolated from blood and cerebrospinal fluid of septic infants on plasminogen activation was studied. These strains typically carry a filamentous surface protein, S fimbria, that has formerly been shown to bind to endothelial cells and interact with plasminogen. The bacteria effectively promoted plasminogen activation by tissue plasminogen activator (t-PA) which was inhibited by s-aminocaproic acid. A recombinant strain expressing S fimbriae accelerated t-PA-catalyzed plasminogen activation to a similar extent as did the wild-type strains whereas the nonfimbriate recipient strain had no effect. After incubation with t-PA and plasminogen, the S-fimbriate strain displayed bacterium-bound plasmin activity whereas the nonfimbriate strain did not. Bacterium-associated plasmin generation was also observed with a strain expressing mutagenized S fimbriae that lack the cell-binding subunit SfaS but not with a strain lacking the major subunit SfaA. Both t-PA and plasminogen bound to purified S fimbriae in a lysine-dependent manner and purified S fimbriae accelerated t-PA-catalyzed plasminogen activation. The results indicate that E. coli S fimbriae form a complex with t-PA and plasminogen which enhances the rate of plasminogen activation and generates bacterium-bound plasmin. This may promote bacterial invasion and persistence in tissues and contribute to the systemic activation of fibrinolysis in septicaemia.