bluuebunny/crossref_metadata_2025_split huggingface dataset:
Landslide‐generated wave hazard prediction based on multiphase flow model of DualSPHysics
Authors: Jiang Quan , Chen Xiliang 
Published: April 2019

AbstractBecause involving a large number of discrete particles interacting with water, simulating the fluid–solid coupling problem of landslide‐generated waves in a virtual environment is very difficult. This paper employs the DualSPHysics multiphase flow model to relatively easily simulate the dynamics of landslide‐generated waves in large scales. In addition, the simulation results are well visualized by the marching cubes algorithm. It is found that, when the factors of the landslide scale, the water length, and water depth are fixed, the initial maximum wave height decreases as the water width increases. After the water is squeezed by the falling slider, one‐way and two‐way propagations of the surge are generated under 2D and 3D conditions, respectively. In addition, under the true‐3D condition, although the initial swell generated is smaller than the 2D and quasi‐2D conditions, it will generate a large wave height during the climbing and undulation of the near shore. In the 2D condition, the surge generated is almost the largest. Therefore, when using the DualSPHysics multiphase flow model to predict the maximum wave height generated by landslide surges, a 2D simulation can be used to improve work efficiency.
Synthesis of Benzophenones and in vitro Evaluation of Their Anticancer Potential in Breast and Prostate Cancer Cells
Authors: Saidi Lydia , Rocha Djenisa H. A. , Talhi Oualid , Bentarzi Yamina , Nedjar‐Kolli Bellara , Bachari Khaldoun , Almeida Paz Filipe A. , Helguero Luisa A. , Silva Artur M. S. 
Published: April 2019

AbstractBreast and prostate cancers are frequently treated with chemotherapy. Several novel chemicals are being reported for this purpose, particularly synthetic and natural benzophenones. This work reports the synthesis of substituted 2‐hydroxybenzophenones through 1,4‐conjugate addition/intramolecular cycloaddition/dehydration of nitromethane on key intermediate chromones. Structures were extensively studied by means of 2D NMR spectroscopy and single‐crystal XRD. Their cytotoxicity was evaluated in vitro in two breast cancer cell lines (MDA‐MB‐231 and T47‐D) and one prostate cancer cell line (PC3). The most potent compound exhibited good cytotoxic effects against the three cancer cell lines (IC50values ranging from 12.09 to 26.49 μm) and induced cell‐cycle retardation only on prostate cancer cells, which suggested that it might exert cell‐type‐specific effects.
Examining the color, size, and packaging design of wireless‐mouse products
Authors: Kuo Lung‐Wen , Lai Chih‐Chun 
Published: April 2019

AbstractWith the progress of science and technology, computer peripheral products are constantly evolving. The use of touch rather than mouse operation in mobile devices such as tablets and smartphones has gained popularity because of its convenience for browsing the Internet and using apps or communication software. However, the mouse remains an essential piece of equipment for using computer software to design products and playing computer games. Wireless mice were the subject of this study, which investigated the optimal size, color, and packaging style for various mouse products. First, this study involved assessment and comparison of the sizes of commercially available wireless mice. Five sizes of mouse were selected. We then designed experiments, and participants performed tasks and completed questionnaires. The results were collected and analyzed to select the optimum product size for users. The study examined the user's psychological and emotional responses to mouse color. By conducting semantic differential analysis, 16 colors were selected for psychological testing, and the results were analyzed to identify the most suitable color. Finally, we investigated the optimal packaging styles for mouse products. In the experiment, eight styles were combined with 10 colors to produce 80 packaging styles. We use the Likert scale to collect data. The results show that the black mouse and the size of 64.5 × 95 × 35 mm3 are the most popular.
Genetic diversity and phylogeography of Daphnia similoides sinensis located in the middle and lower reaches of the Yangtze River
Authors: Wu Jianxun , Wang Wenping , Deng Daogui , Zhang Kun , Peng Shuixiu , Xu Xiaoxue , Zhang Yanan , Zhou Zhongze 
Published: April 2019

AbstractGeographical patterns, climate, and environmental change have important influences on the distribution and spread of aquatic organisms. However, the relationships between the geographical pattern and phylogenetics of Daphnia as well as environmental change are not well known. The genetic diversity and phylogeography of seven D. similoides sinensis populations located in the middle and lower reaches of the Yangtze River were investigated based on the combination of mitochondrial (COI gene) and nuclear (14 microsatellite primers) markers. Based on the mitochondrial gene markers, D. similoides sinensis from the middle and lower reaches of the Yangtze River had one ancestral haplotype and two evolutionary clades. In addition, D. similoides sinensis population deviated from neutral evolution, showing signs of a bottleneck effect followed by population expansion. Based on the microsatellite markers, the seven D. similoides sinensis populations formed three main groups. The dendrogram (NJ/ME) showed that D. similoides sinensis based on the mitochondrial genes marker were obviously clustered two main clades, whereas there were three clades based on the microsatellite markers. Our results suggested that the habitat fragmentation due to the barrier of the dams and sluices promoted the genetic differentiation and phylogeography of D. similoides sinensis populations in the middle and lower reaches of the Yangtze River.
Identification of key genes and pathways in benign prostatic hyperplasia
Authors: Ke Zhi‐Bin , Cai Hai , Wu Yu‐Peng , Lin Yun‐Zhi , Li Xiao‐Dong , Huang Jin‐Bei , Sun Xiong‐Lin , Zheng Qing‐Shui , Xue Xue‐Yi , Wei Yong , Xu Ning 
Published: April 2019

AbstractBenign prostatic hyperplasia (BPH) is one of the most common causes of lower urinary tract symptoms (LUTS) in elderly man. However, the underlying molecular mechanisms of BPH have not been completely elucidated. We identified the key genes and pathways by using analysis of Gene Expression Omnibus (GEO) database. Differentially expressed genes (DEGs) were identified using edgeR. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses were performed for the DEGs by Database for Annotation, Visualization and Integrated Discovery (DAVID) database and ConsensusPathDB, respectively. Then, protein–protein interaction (PPI) networks were established by the Search Tool for the Retrieval of Interacting Genes (STRING) database and visualized by Cytoscape software. Finally, we identified 660 DEGs ultimately including 268 upregulated genes and 392 downregulated genes. GO analysis revealed that DEGs were mainly enriched in extracellular exosome, identical protein binding, mitochondrial adenosine triphosphate (ATP) synthesis coupled proton transport, extracelluar matrix, focal adhesion, cytosol, Golgi apparatus, cytoplasm, protein binding, and Golgi membrane. Focal adhesion pathway, FoxO signaling pathway, and autophagy pathway were selected. Ubiquitin‐conjugating enzyme E2 C (UBE2C), serine/threonine kinase (AKT1), mitogen‐activated protein kinase 1 (MAPK1), cyclin B1 (CCNB1), polo‐like kinase 1 (PLK1) were filtrated as the hub genes according to the degree of connectivity from the PPI network. The five hub genes including UBE2C, AKT1, MAPK1, CCNB1, PLK1 may play key roles in the pathogenesis of benign prostatic hyperplasia (BPH). Focal adhesion pathway, FoxO signaling pathway, and autophagy pathway may be crucial for the progression of BPH.
The potential role of miR‐29 in health and cancer diagnosis, prognosis, and therapy
Authors: Alizadeh Mohsen , Safarzadeh Ali , Beyranvand Fatemeh , Ahmadpour Fatemeh , Hajiasgharzadeh Khalil , Baghbanzadeh Amir , Baradaran Behzad 
Published: April 2019

AbstractmiR‐29 family is one of the small noncoding RNAs and has a very important role in many physiologic and pathologic functions through regulating the target genes that play roles in various bioprocesses such as proliferation, survival, apoptosis, and angiogenesis. Thus, we aim to survey the potential of the miR‐29 family in normal model and development and progression of malignancy in this study. In addition, the potential role of miR‐29 family has been studied as the clinical marker for the diagnosis and prognosis of many cancers as the potential targets to treat cancer. Moreover, it was stated in summary that the herbal compounds can regulate miR‐29 family in cancers. Therefore, regulating the expression of the miR‐29 family in a variety of cancers can be a new strategy to obtain better results from cancerous patients’ treatment in the future.
Sox2 dosage: A critical determinant in the functions of Sox2 in both normal and tumor cells
Authors: Metz Ethan P. , Rizzino Angie 
Published: April 2019

AbstractThe stem cell transcription factor Sox2 is widely recognized for its many roles during normal development and cancer. Over the last several years, it has become increasingly evident that Sox2 dosage plays critical roles in both normal and malignant cells. The work described in this review indicates that the dosage of Sox2 influences cell fate decisions made during normal mammalian development, as well as cell fate decisions in cancer, including those that influence the tumor cell of origin and progression of the cancer. Equally important, Sox2 dosage is a key determinant in the proliferation of both normal cells and tumor cells, where proliferation is restricted in Sox2high cells. Collectively, the studies reviewed here indicate that tumor cells utilize the fundamental effects of Sox2 dosage to suit their own needs. Finally, we speculate that elevated expression of Sox2 helps establish and maintain tumor dormancy in Sox2‐positive cancers.
Solution Properties of Alkyl β‐D‐Maltosides
Authors: Li Zhencao , Chen Guoyong , Chen Langqiu , Zhang Yanhua , Dai Zhiyong 
Published: April 2019

AbstractAlkyl β‐D‐maltosides are an important class of sugar‐based nonionic surfactants and have been widely studied. Nevertheless, it is still necessary to investigate further their amphiphilic structure‐surface property relationships. In this article, we reported a series of properties of synthetic alkyl β‐D‐maltosides (6a–6i, n = 6–18) including their hydrophilic–lipophilic balance (HLB) number, water solubility, hygroscopicity, moisture‐retention capacity, foaming ability, surface tension, thermotropic phase behavior, and skin irritation. Their HLB number and water solubility decreased with increasing alkyl chain length. Hexyl β‐D‐maltoside exhibited the strongest hygroscopicity and moisture‐retention capacity. Decyl β‐D‐maltoside and dodecyl β‐D‐maltoside possessed excellent foaming power and foaming stability. Furthermore, the critical micelle concentration (CMC) of alkyl β‐D‐maltoside (6a–6g, n = 6–14) and their surface tension at CMC decreased with increasing alkyl chain length. At last, alkyl β‐D‐maltosides (6a–6g) should be considered as safe surfactants by the skin irritation assessment.
Adaptation of acneic and non acneic strains of Cutibacterium acnes to sebum‐like environment
Authors: Borrel Valérie , Gannesen Andrei V. , Barreau Magalie , Gaviard Charlotte , Duclairoir‐Poc Cécile , Hardouin Julie , Konto‐Ghiorghi Yoan , Lefeuvre Luc , Feuilloley Marc G. J. 
Published: April 2019

AbstractCutibacterium acnes, former Proprionibacterium acnes, is a heterogeneous species including acneic bacteria such as the RT4 strain, and commensal bacteria such as the RT6 strain. These strains have been characterized by metagenomic analysis but their physiology was not investigated until now. Bacteria were grown in different media, brain heart infusion medium (BHI), reinforced clostridial medium (RCM), and in sebum like medium (SLM) specifically designed to reproduce the lipid rich environment of the sebaceous gland. Whereas the RT4 acneic strain showed maximal growth in SLM and lower growth in RCM and BHI, the RT6 non acneic strain was growing preferentially in RCM and marginally in SLM. These differences were correlated with the lipophilic surface of the RT4 strain and to the more polar surface of the RT6 strain. Both strains also showed marked differences in biofilm formation activity which was maximal for the RT4 strain in BHI and for the RT6 strain in SLM. However, cytotoxicity of both strains on HaCaT keratinocytes remained identical and limited. The RT4 acneic strain showed higher inflammatory potential than the RT6 non acneic strain, but the growth medium was without significant influence. Both bacteria were also capable to stimulate β‐defensine 2 secretion by keratinocytes but no influence of the bacterial growth conditions was observed. Comparative proteomics analysis was performed by nano LC‐MS/MS and revealed that whereas the RT4 strain only expressed triacylglycerol lipase, the principal C. acnes virulence factor, when it was grown in SLM, the RT6 strain expressed another virulence factor, the CAMP factor, exclusively when it was grown in BHI and RCM. This study demonstrates the key influence of growth conditions on virulence expression by C. acnesand suggest that acneic and non acneic strains are related to different environmental niches.
The identification of a RNA splice variant in TULP1 in two siblings with early‐onset photoreceptor dystrophy
Authors: Verbakel Sanne K. , Fadaie Zeinab , Klevering B. Jeroen , van Genderen Maria M. , Feenstra Ilse , Cremers Frans P. M. , Hoyng Carel B. , Roosing Susanne 
Published: April 2019

AbstractBackgroundEarly‐onset photoreceptor dystrophies are a major cause of irreversible visual impairment in children and young adults. This clinically heterogeneous group of disorders can be caused by mutations in many genes. Nevertheless, to date, 30%–40% of cases remain genetically unexplained. In view of expanding therapeutic options, it is essential to obtain a molecular diagnosis in these patients as well. In this study, we aimed to identify the genetic cause in two siblings with genetically unexplained retinal disease.MethodsWhole exome sequencing was performed to identify the causative variants in two siblings in whom a single pathogenic variant in TULP1 was found previously. Patients were clinically evaluated, including assessment of the medical history, slit‐lamp biomicroscopy, and ophthalmoscopy. In addition, a functional analysis of the putative splice variant in TULP1 was performed using a midigene assay.ResultsClinical assessment showed a typical early‐onset photoreceptor dystrophy in both the patients. Whole exome sequencing identified two pathogenic variants in TULP1, a c.1445G>A (p.(Arg482Gln)) missense mutation and an intronic c.718+23G>A variant. Segregation analysis confirmed that both siblings were compound heterozygous for the TULP1 c.718+23G>A and c.1445G>A variants, while the unaffected parents were heterozygous. The midigene assay for the c.718+23G>A variant confirmed an elongation of exon 7 leading to a frameshift.ConclusionHere, we report the first near‐exon RNA splice variant that is not present in a consensus splice site sequence in TULP1, which was found in a compound heterozygous manner with a previously described pathogenic TULP1 variant in two patients with an early‐onset photoreceptor dystrophy. We provide proof of pathogenicity for this splice variant by performing an in vitro midigene splice assay, and highlight the importance of analysis of noncoding regions beyond the noncanonical splice sites in patients with inherited retinal diseases.
Identifying and treating intrinsic PEEP in infants with severe bronchopulmonary dysplasia
Authors: Napolitano Natalie , Jalal Khair , McDonough Joseph M. , Monk Heather M. , Zhang Huayan , Jensen Erik , Dysart Kevin C. , Kirpalani Haresh M. , Panitch Howard B. 
Published: April 2019

AbstractRationaleInfants with severe bronchopulmonary dysplasia (sBPD) and airway obstruction may develop dynamic hyperinflation and intrinsic positive end‐expiratory pressure (PEEPi), which impairs patient/ventilator synchrony.ObjectivesTo determine if PEEPi is present in infants with sBPD during spontaneous breathing and if adjusting ventilator PEEP improves patient/ventilator synchrony and comfort.MethodsInterventional study in infants with sBPD. PEEPi measured by esophageal pressure (Pes) and pneumotachometer, during pressure‐supported breaths. PEEP
i defined as the difference between Pes at start of the inspiratory effort minus Pes at onset of inspiratory flow. The set PEEP was adjusted to minimize PEEP
i. “Best PEEP” was the setting with minimal wasted efforts (WE), an inspiratory effort seen on the Pes waveform without a corresponding ventilator breath. FiO
2 and SpO
2 measured pre‐ and post‐PEEP adjustment. Sedation requirements evaluated 72 hours preprocedure and postprocedure.ResultsTwelve infants were assessed (gestational age, 24.9 ± 1.4 weeks; study age, 48.8 ± 1.5 weeks, postmenstrual age). Mean baseline ventilator PEEP was 16.4 cm H2O (14‐20 cm H
2O). Eight infants required an increase, one, a reduction, and three, no change in the set PEEP. For the eight infants requiring an increase in set PEEP, there was an 18.9% reduction in WE and a reduction in FiO
2 (0.084
±
0.058) requirements in the subsequent 24 hours. Conditional sedation was reduced in five infants postprocedure. No adverse events occurred during testing.ConclusionPEEPi is measurable in infants with sBPD with concurrent esophageal manometry and flow‐time tracings without the need for pharmacological paralysis. In those with PEEP
i, increasing ventilator PEEP to offset PEEP
i improves synchrony.
Different anti‐Műllerian hormone (AMH) levels respond to distinct ovarian stimulation methods in assisted reproductive technology (ART): Clues to better ART outcomes
Authors: Ishii Rena , Tachibana Naoyuki , Okawa Riho , Enomoto Megumi , Asami Mai , Toriumi Rena , Hamada Michiko , Horikawa Michiharu , Akiba Yoko , Taketani Yuji 
Published: April 2019

AbstractPurposeWe asked whether the relationship between anti‐Műllerian hormone (AMH) value and the response to ovarian stimulation (OS) might be AMH value‐related and differ for each regimen, aiming at getting clues as to how to choose OS protocols according to AMH levels. We further addressed how AMH value connects with ART outcome.MethodsA total of 1112 women undergoing egg retrieval in ART were included. We adopted four OS protocols, that is, clomiphene, clomiphene + low‐dose gonadotropins (Gns), GnRH (Gn‐releasing hormone) + Gns (short), and GnRH antagonist.ResultsAnti‐Műllerian hormone showed a stronger correlation with egg number compared with age over a wide age range. When patients were stratified into four groups by AMH value (<1, 1‐2, 2‐3, and 3≦ ng/mL), the relationship between AMH and egg number differed among differential OS regimes. The number of eggs rose as AMH and total doses of Gn increased. When analyzed for each AMH group, egg number, but not AMH, was associated with pregnancy rate.ConclusionDifferent AMH levels exhibit characteristic responses to distinct OS regimens. To improve ART outcomes, personalized OS should be selected so as to maximize egg number, which seems to be a more precise variable than AMH for predicting pregnancy.
Prenatal identification of small‐for‐gestational age and risk of neonatal morbidity and stillbirth
Authors: Nohuz E. , Rivière O. , Coste K. , Vendittelli F. 
Published: April 2019

ABSTRACTObjectiveTo assess whether prenatal identification of small‐for‐gestational age (SGA) was associated with lower rates of the primary composite outcome of stillbirth, death in the delivery room or neonatal complications, and secondary outcomes of the composite outcome according to gestational age at delivery, stillbirth and low 5‐min Apgar score.MethodsThis historical cohort study included women who had a singleton delivery (≥ 32 weeks) between 1994 and 2011 at one of 247 French maternity units. We excluded pregnancies terminated medically, infants with malformations or with missing data on estimated fetal weight or birth weight, and women with missing delivery data. Among the 24 946 infants born SGA (< 5th percentile), we compared those who had been identified as such prenatally (n = 5093; 20%), with those who had not (n = 19 853; 80%). The main outcome was a composite variable defined as stillbirth or death in the delivery room, or transfer to a neonatal department either immediately or during the neonatal stay in the obstetrics ward. Secondary outcomes were the composite outcome according to gestational age at delivery (32 to < 35 weeks; 35 to < 37 weeks, 37 to < 40 weeks, or ≥ 40 weeks), stillbirth and low 5‐min Apgar score (≤ 4 and < 7).ResultsThe mean ± SD birth weight was 2449.1 ± 368.3 g. The rate of the main composite outcome was higher in the group identified prenatally as SGA compared with non‐identified SGA fetuses (39.5% vs 13.5%; adjusted relative risk (aRR), 1.29; 95% CI, 1.21–1.38). This association was not observed in the subgroups delivered before 37 weeks. The stillbirth rate was lower in fetuses with prenatal suspicion of SGA (aRR, 0.47; 95% CI, 0.27–0.79), while the 5‐min Apgar score did not differ between the two groups. The a‐posteriori study power with α = 0.05 was 99%.ConclusionPrenatal identification of SGA was not associated with lower fetal or neonatal morbidity overall, although it was associated with a lower rate of stillbirth. Copyright © 2019 ISUOG. Published by John Wiley & Sons Ltd.
Constructing Inductive-Inductive Types in Cubical Type Theory
Authors: Hugunin Jasper 
Published: April 2019

AbstractInductive-inductive types are a joint generalization of mutual inductive types and indexed inductive types. In extensional type theory, inductive-inductive types can be constructed from inductive types, and this construction has been conjectured to work in intensional type theory as well. In this paper, we show that the existing construction requires Uniqueness of Identity Proofs, and present a new construction (which we conjecture generalizes) of one particular inductive-inductive type in cubical type theory, which is compatible with homotopy type theory.
Immediate response to major incidents: defining an immediate responder!
Authors: Khorram-Manesh Amir , Plegas Patricia , Högstedt Åsa , Peyravi Mahmoudreza , Carlström Eric 
Published: April 2019

Abstract
Purpose
There is a gap in time between the occurrence of a mass casualty incident (MCI) and the arrival of the first responders to the scene, which offers an opportunity for the public (immediate responders) to perform life-saving measures. The purpose of this study was to identify these measures and the public’s willingness to conduct them.

Method
An extensive literature review was performed to identify the possible measures that can be undertaken by the public. A group of experts were asked to prioritize and rank the feasibility of performing the measures by the public. Finally, the public was asked whether they were willing to do the chosen measures before and after an appropriate education.

Results
Twenty different measures were identified and presented in a questionnaire as statements, which were prioritized and ranked by the expert group into four categories: what (1) should be done, (2) is good to know how, (3) is not necessary to know, and (4) should not be done. All statements were converted into understandable statements and were sent to the public. There were some differences and some agreements between the experts and the public regarding what an immediate responder should do. However, the willingness of the public to perform most of the measures was high and increased after being offered an appropriate education.

Conclusion
The use of immediate responders is a life-saving approach in MCIs and in situations when every minute counts and every human resource is an invaluable asset. Multiple steps, such as education, empowerment, and access, should be taken into consideration to enable bystanders to effectively help struggling survivors.