bluuebunny/crossref_metadata_2025_split huggingface dataset:
Twenty‐four‐hour ambulatory ECG monitoring relevancy in myotonic dystrophy type 1 follow‐up: Prognostic value and heart rate variability evolution
Authors: Gamet Alexandre , Degand Bruno , Le Gal François , Bidegain Nicolas , Delaubier Anne , Gilbert‐Dussardier Brigitte , Christiaens Luc , Garcia Rodrigue 
Published: August 2018

AbstractBackgroundPatient prognosis in type 1 myotonic dystrophy (DM1) is very poor. Annual 24‐hour holter ECG monitoring is recommended but its relevance is debated. Main objective was to determine whether holter ECG parameters could predict global death in DM1 patients and secondarily to assess whether they could predict cardiovascular events and sudden cardiac death, to compare DM1 patients and healthy controls, and to assess their evolution in DM1 over a 5‐year period.MethodsThis retrospective study included genetically confirmed DM1. Primary endpoint was global death. Secondary endpoints were labeled “sudden cardiac death” which was a composite of sudden cardiac death, aborted sudden cardiac death, implantable cardioverter defibrillator therapy, sustained ventricular tachycardia, atrioventricular block grade 3, pause >3 s; and “cardiovascular events” which was a composite of all‐cause mortality, pacemaker or cardioverter defibrillator implantation, sustained ventricular tachycardia, supraventricular tachycardia, hospitalization for acute cardiac cause and heart failure.ResultsForty‐seven patients (22 women, 40 ± 13 years old) were included. Three (7%) DM1 patients died, 9 (19%) experienced "sudden cardiac death" endpoint and 21 (45%) experienced "cardiovascular event" endpoint during mean follow‐up of 95 ± 22 months. None of holter ECG parameters were discriminant to predict death or secondary endpoints. Compared to healthy controls, DM1 patients had higher SDNN and LF/HF ratio. Finally, heart rate variability parameters remained stable over a mean interval of 61 ± 15 months excepting pNN50 which decreased significantly.ConclusionResults suggest that annually‐repeated holter ECG in DM1 is not useful for stratifying risk of sudden death and cardiovascular outcomes.
The Meaning of Resilience as a Psychoanalytic Concept: An exploratory Study of the Perspectives of Training and Supervising Psychoanalysts
Authors: Malgarim Bibiana Godoi , Macedo Mônica Medeiros Kother , Freitas Lúcia Helena 
Published: August 2018

Objective The objective of this study was to investigate how psychoanalysts perceive the concept of resilience and how it can be applied in this field.
Method Exploratory qualitative research was undertaken with a sampleof 10 training and supervising psychoanalysts belonging to a psychoanalytic institution in southern Brazil. A semi‐structured interview was used to collect the data.
Results Based on the material collected, the following final four categories were established: (1) the evident complexity of the origin andconceptual definition of resilience; (2) the technical potential ofresilience: communication and effects from a psychoanalytical perspective; (3) the life stories and difficulties of resilient beings: conditions, characteristics and development; and (4) the association between the clinical aspects of trauma and a subject's resources – resilience under discussion.
Conclusions The origin of the phenomenon of resilience opens up important questions and reflections for psychoanalysts even though the term's technical potential for the psychoanalytic clinic is recognized and serves as an important prognostic factor. Resilience relates to personality and resources of the ego, and this fact would seem to suggest the need for further study into the aetiological equation. It can be defined as the ability to elaborate on one's experiences.
Early Childhood Parenting Predicts Late Childhood Brain Functional Connectivity During Emotion Perception and Reward Processing
Authors: Kopala‐Sibley Daniel C. , Cyr Marilyn , Finsaas Megan C. , Orawe Jonathan , Huang Anna , Tottenham Nim , Klein Daniel N. 
Published: August 2018

Seventy‐nine 3‐year olds and their mothers participated in a laboratory‐based task to assess maternal hostility. Mothers also reported their behavioral regulation of their child. Seven years later, functional magnetic resonance imaging data were acquired while viewing emotional faces and completing a reward processing task. Maternal hostility predicted more negative amygdala connectivity during exposure to sad relative to neutral faces with frontal and parietal regions as well as more negative left ventral striatal connectivity during monetary gain relative to loss feedback with the right posterior orbital frontal cortex and right inferior frontal gyrus. In contrast, maternal regulation predicted enhanced cingulo‐frontal connectivity during monetary gain relative to loss feedback. Results suggest parenting is associated with alterations in emotion and reward processing circuitry 7–8 years later.
A multianalysis thermography‐based approach for fatigue and damage investigations of ASTM A182 F6NM steel at two stress ratios
Authors: De Finis Rosa , Palumbo Davide , Galietti Umberto 
Published: August 2018

AbstractInfrared thermography allows an alternative energy‐based approach for studying the fatigue behaviour of materials to better understand damage phenomena. In particular, the methodology of infrared thermography can explain the complex dissipative mechanisms promoted by the input parameters, such as the loading ratio, can rapidly provide information about the fatigue strength, and has low cost.In this work, analysis of the thermographic sequences of ASTM A 182 grade F6NM steel obtained during fatigue testing provided four thermal indexes that were used to investigate the thermoelastic and plastic behaviour of material. Fatigue tests at two opportunely chosen loading ratios (R = −0.1, R = 0.5) were performed to investigate the relation between the material behaviour and each index at a specific loading ratio. Finally, estimation of the fatigue strength by means of suitable analysis procedures allowed for an investigation of the damage behaviour of materials under specific loading conditions.
The Ordovician and Silurian conodonts of Japan: Their biostratigraphical and paleobiogeographical significance
Authors: Männik Peep , Maekawa Takumi , Tanaka Gengo , Komatsu Toshifumi , Siveter David , Williams Mark , Hints Olle , Vandenbroucke Thijs R. A. 
Published: August 2018

AbstractConodont‐bearing Ordovician and Silurian rocks have a wide geographical distribution in Japan. They are exposed on Honshu, Shikoku, and Kyushu islands. Two recently studied samples from Gionyama, in Kyushu, yield conodont assemblages of Telychian (Distomodus sp., Apsidognathus sp. (cf. A. tuberculatus arcticus), Oulodus cf. rectangulus, Ozarkodina cf. waugoolaensis, Panderodus cf. amplicostatus) and probably the earliest Sheinwoodian (?Distomodus sp. (cf. D. staurognathoides), Ozarkodina sp., Oulodus sp., Walliserodus sp. (cf. Walliserodus sp. nov. c Männik), Panderodus sp.) ages, providing further biostratigraphical constraints for the age of the Gionyama Formation in the Kurosegawa Terrane. Most of the conodont taxa identified have wide paleobiogeographical distribution, but probable occurrence of Oulodus rectangulus, Ozarkodina waugoolaensis, and Panderodus amplicostatus suggests a relationship between Australia, the South China paleocontinent, and the Kurosegawa Terrane of ‘Proto‐Japan’ during the Silurian. These paleogeographic interpretations agree with the existing notions based on rugose corals.
Serum Mac‐2 binding protein glycosylation isomer predicts the activation of hepatic stellate cells after liver transplantation
Authors: Yamada Naoya , Katano Takumi , Hirata Yuta , Okada Noriki , Sanada Yukihiro , Ihara Yoshiyuki , Urahashi Taizen , Ushijima Kentaro , Karasawa Tadayoshi , Takahashi Masafumi , Mizuta Koichi 
Published: August 2018

AbstractBackground and AimSerum Mac‐2 binding protein glycosylation isomer (M2BPGi) is a novel fibrosis marker for various chronic liver diseases. We investigated the ability of M2BPGi to predict liver fibrosis in liver transplant (LT) recipients.MethodsA total of 116 liver biopsies were performed in 113 LT recipients. The serum level of M2BPGi was also measured on the same day. The median age at LT and liver biopsy was 1.1 and 11.8 years, respectively. Serum M2BPGi levels and liver fibrosis status using METAVIR fibrosis score were compared. Immunohistological evaluation by anti‐α‐smooth‐muscle actin (αSMA) was performed, and the relationship between αSMA positive rate and serum M2BPGi levels was investigated.ResultsThe median M2BPGi level was 0.78 (range, 0.22–9.50), and 65, 29, 16, 5, and 1 patient(s) had METAVIR fibrosis scores of F0, F1, F2, F3, and F4, respectively. In patients with F0 fibrosis, median M2BPGi level was 0.69 and was significantly lower than in patients with F1 (median 0.99, P < 0.01), F2 (median 1.00, P = 0.01), and F3 fibrosis (median 1.53, P < 0.01). Area‐under‐the‐curve analysis of the ability of M2BPGi level to predict liver fibrosis grade were > F1: 0.716, > F2: 0.720, and > F3: 0.900. Three patients with acute cellular rejection showed high levels of M2BPGi, which decreased after the treatment. A positive correlation existed between M2BPGi levels and αSMA positive rate (r2 = 0.715, P < 0.01).ConclusionMac‐2 binding protein glycosylation isomer is a novel liver fibrosis marker in LT recipients and is also increased in patients with acute liver injuries, especially acute cellular rejection, even when fibrosis is absent.
A comparative study of subsequent liver cirrhosis risk in non‐Helicobacter pylori‐infected peptic ulcer patients with and without vagotomy: An Asian population cohort study
Authors: Wu Shih‐Chi , Chen William Tzu‐Liang , Muo Chih‐Hsin , Hsu Chung Y 
Published: August 2018

AbstractObjectivesHepatic parasympathetic nerves branch off the vagus nerve. The vagal and hepatic nervous systems are important in liver physiological processes and some diseases such as diabetes, obesity, and liver cirrhosis. We were interested in vagal nerve integrity and subsequent diseases in peptic ulcer patients. Herein, we used National Health Insurance database in Taiwan and retrospectively assessed the risk of developing liver cirrhosis in peptic ulcer patients with and without complications by surgical treatments.MethodsA cohort of 357 423 peptic ulcer patients without Helicobacter pylori, hepatitis B/C virus infection, and alcoholism from 2001 to 2008 was established. A randomly selected cohort of 357 423 people without peptic ulcer that matched by age, gender, comorbidities, and index year was used for comparison. The risks of developing liver cirrhosis were assessed both in cohorts and in peptic ulcer patients with and without vagotomy at the end of 2011.ResultsPeptic ulcer patients were with higher incidence of liver cirrhosis than those without peptic ulcer (2.63 vs 0.96 per 1000 person‐years) and with a 2.79‐fold adjusted hazard ratio (HR) (95% confidence interval = 2.66–2.93) based on the multivariable Cox proportional hazards regression analysis. Comparing with different peptic ulcer management strategies, the HR value for subsequent liver cirrhosis risk was the lowest in vagotomy group (HR = 0.46, 95% confidence interval = 0.33–0.64).ConclusionsPeptic ulcer patients have an increased risk of developing liver cirrhosis. Moreover, there were association of vagotomy and decreased risk of subsequent liver cirrhosis in complicated peptic ulcer patients. However, further studies are warranted.
Long‐term outcome of primary immune‐mediated thrombocytopenia in dogs
Authors: Simpson K. , Chapman P. , Klag A. 
Published: August 2018

ObjectivesTo determine the incidence of relapse after discharge from the hospital in dogs with a diagnosis of presumed primary immune‐mediated thrombocytopenia, risk factors associated with relapse and whether or not indefinite use of immunosuppressive medication influences risk of relapse.Materials and MethodsMedical records from August 2007 through July 2016 were reviewed to identify dogs with a diagnosis of presumed primary immune‐mediated thrombocytopenia. Data collection included signalment, initial diagnostic tests, treatment, incidence of relapse, survival duration and follow‐up testing.ResultsA total of 45 dogs were diagnosed, treated and monitored for at least one year for presumed primary immune‐mediated thrombocytopenia. 89∙6% of patients survived to discharge and 31% of those experienced a relapse following discharge. The median time from diagnosis to relapse was 79 days. Of dogs that experienced a relapse, 50% had at least one further relapse. There was no difference in age, body weight, gender, breed, platelet count at presentation, nadir packed cell volume during hospitalisation, incidence of melaena or initial treatment between the relapsing and non‐relapsing groups. In the relapsing group, time to platelet recovery was significantly longer and these patients were more likely to have received a blood transfusion.Clinical SignificanceThis study does not provide evidence to support the use of long‐term immunosuppressive medications to prevent relapse. However, the data suggest that patients with more severe disease at the time of diagnosis or that have already experienced a relapse should be monitored more closely.
Regulation of Melanopsin Signaling: Key Interactions of the Nonvisual Photopigment
Authors: Stachurska Anna , Sarna Tadeusz 
Published: August 2018

AbstractMelanopsin is a G protein‐coupled receptor with a peak sensitivity in the blue part of the spectrum, which plays a key role in nonvisual light‐mediated signaling. Recently, its importance in forming visual pathway as well as its role in blood vessels photorelaxation was also revealed. Melanopsin was discovered in 1998 in Xenopus leavis. Since then, the melanopsin presence was demonstrated across the species. The existence of two melanopsin genes (opn4m and opn4x) as well as melanopsin isoforms resulting from alternative splicing contributes to the variety in melanopsin‐regulated processes. In this review, the diversity in melanopsin‐induced signaling, regulation of melanopsin activity by phosphorylation and regulation of melanopsin mRNA are discussed.
Kidney transplant recipients with polycystic kidney disease have a lower risk of post‐transplant BK infection than those with end‐stage renal disease due to other causes
Authors: Plafkin Callie , Singh Tripti , Astor Brad C. , Parajuli Sandesh , Bhutani Gauri , Safdar Nasia , Panzer Sarah E. 
Published: August 2018

AbstractBackgroundPolyomavirus‐associated nephropathy is associated with high risk of kidney allograft loss. Whether the cause of native end‐stage renal disease influences the risk of BK infection is unclear.MethodsA retrospective, single‐center study of 2741 adult kidney transplant recipients between 1994 and 2014 was performed. Recipients had end‐stage renal disease due to polycystic kidney disease (PKD, n = 549), diabetes mellitus (DM, n = 947), hypertension (HTN, n = 442), or glomerulonephritis (GN, n = 803).ResultsA total of 327 recipients (12%) developed post‐transplant BK viremia over a median follow‐up time of 5 years. The incidence rate of BK viremia was lowest in patients with PKD (1.46 per 100 person‐years) compared to other causes of ESRD (DM = 2.06, HTN = 2.65, and GN = 2.01 per 100 person‐years). A diagnosis of PKD was associated with a lower risk of post‐transplant BK viremia (adjusted HR (95% CI) = 0.67 (0.48‐0.95), P = 0.02). BK nephropathy was significantly less common in patients with PKD (0.21 per 100 person‐years) compared to those with HTN (0.80 per 100 person‐years, P ≤ 0.001). Among patients with PKD, the risk of BK viremia was lower in patients with nephrectomy, compared to those without nephrectomy (adjusted HR (95% CI) = 0.42 (0.19‐0.92), P < 0.05).ConclusionESRD due to PKD is associated with a lower risk of post‐transplant BK infection. The renal tubular epithelial cells in PKD are unique; they are in a proliferative but non‐differentiated state. Whether this characteristic of renal tubular epithelial cells alters the BK viral reservoir or replication in PKD patients warrants further study.
Cost-effectiveness of habit-based advice for weight control versus usual care in general practice in the Ten Top Tips (10TT) trial: economic evaluation based on a randomised controlled trial
Authors: Patel Nishma , Beeken Rebecca J , Leurent Baptiste , Omar Rumana Z , Nazareth Irwin , Morris Stephen 
Published: August 2018

ObjectiveTen Top Tips (10TT) is a primary care-led behavioural intervention which aims to help adults reduce and manage their weight by following 10 weight loss tips. The intervention promotes habit formation to encourage long-term behavioural changes. The aim of this study was to estimate the cost-effectiveness of 10TT in general practice from the perspective of the UK National Health Service.DesignAn economic evaluation was conducted alongside an individually randomised controlled trial.Setting14 general practitioner practices in England.ParticipantsAll patients were aged ≥18 years, with body mass index ≥30 kg/m2. A total of 537 patients were recruited; 270 received the usual care offered by their practices and 267 received the 10TT intervention.Outcomes measuresHealth service use and quality-adjusted life years (QALYs) were measured over 2 years. Analysis was conducted in terms of incremental net monetary benefits (NMBs), using non-parametric bootstrapping and multiple imputation.ResultsOver a 2-year time horizon, the mean costs and QALYs per patient in the 10TT group were £1889 (95% CI £1522 to £2566) and 1.51 (95% CI 1.44 to 1.58). The mean costs and QALYs for usual care were £1925 (95% CI £1599 to £2251) and 1.51 (95% CI 1.45 to 1.57), respectively. This generated a mean cost difference of −£36 (95% CI −£512 to £441) and a mean QALY difference of 0.001 (95% CI −0.080 to 0.082). The incremental NMB for 10TT versus usual care was £49 (95% CI −£1709 to £1800) at a maximum willingness to pay for a QALY of £20 000. 10TT had a 52% probability of being cost-effective at this threshold.ConclusionsCosts and QALYs for 10TT were not significantly different from usual care and therefore 10TT is as cost-effective as usual care. There was no evidence to recommend nor advice against offering 10TT to obese patients in general practices based on cost-effectiveness considerations.Trial registration numberISRCTN16347068; Post-results.
Actin Cytoskeleton Remodeling Drives Breast Cancer Cell Escape from Natural Killer–Mediated Cytotoxicity
Authors: Al Absi Antoun , Wurzer Hannah , Guerin Coralie , Hoffmann Celine , Moreau Flora , Mao Xianqing , Brown-Clay Joshua , Petrolli Rémi , Casellas Carla Pou , Dieterle Monika , Thiery Jean-Paul , Chouaib Salem , Berchem Guy , Janji Bassam , Thomas Clément 
Published: August 2018

AbstractElucidation of the underlying molecular mechanisms of immune evasion in cancer is critical for the development of immunotherapies aimed to restore and stimulate effective antitumor immunity. Here, we evaluate the role of the actin cytoskeleton in breast cancer cell resistance to cytotoxic natural killer (NK) cells. A significant fraction of breast cancer cells responded to NK-cell attack via a surprisingly rapid and massive accumulation of F-actin near the immunologic synapse, a process we termed “actin response.” Live-cell imaging provided direct evidence that the actin response is associated with tumor cell resistance to NK-cell–mediated cell death. High-throughput imaging flow cytometry analyses showed that breast cancer cell lines highly resistant to NK cells were significantly enriched in actin response-competent cells as compared with susceptible cell lines. The actin response was not associated with a defect in NK-cell activation but correlated with reduced intracellular levels of the cytotoxic protease granzyme B and a lower rate of apoptosis in target cells. Inhibition of the actin response by knocking down CDC42 or N-WASP led to a significant increase in granzyme B levels in target cells and was sufficient to convert resistant breast cancer cell lines into a highly susceptible phenotype. The actin response and its protective effects were fully recapitulated using donor-derived primary NK cells as effector cells. Together, these findings establish the pivotal role of actin remodeling in breast cancer cell resistance to NK-cell–mediated killing.Significance: These findings establish the pivotal role of the actin cytoskeleton in driving breast cancer cell resistance to natural killer cells, a subset of cytotoxic lymphocytes with important roles in innate antitumor immunity. Cancer Res; 78(19); 5631–43. ©2018 AACR.
Rethinking Gamma-secretase Inhibitors for Treatment of Non–small-Cell Lung Cancer: Is Notch the Target?
Authors: Pine Sharon R. 
Published: August 2018

Abstract
Lung cancer is the leading cause of cancer-related deaths among men and women. γ-Secretase inhibitors, a class of small-molecule compounds that target the Notch pathway, have been tested to treat non–small-cell lung cancer (NSCLC) in preclinical and clinical trials. Although γ-secretase inhibitors elicit a response in some tumors as single agents and sensitize NSCLC to cytotoxic and targeted therapies, they have not yet been approved for NSCLC therapy. We discuss our recently published preclinical study using the γ-secretase inhibitor AL101, formerly BMS906024, on cell lines and PDX models of NSCLC, primarily lung adenocarcinoma. We propose that Notch pathway mutations may not be the most suitable biomarker for predicting NSCLC response to γ-secretase inhibitors. γ-Secretases have over 100 known γ-secretase cleavage substrates. Many of the γ-secretase substrates are directly involved in carcinogenesis or tumor progression, and are ideal candidates to be the “on-target” biomarkers for γ-secretase inhibitors. We propose the need to systematically test the γ-secretase and other targets as potential biomarkers for sensitivity before continuing clinical trials. Now that we have entered the postgenome/transcriptome era, this goal is easily attainable. Discovery of the biomarker(s) that predict sensitivity to γ-secretase inhibitors would guide selection of the responder population that is most likely to benefit and move the compounds closer to approval for therapeutic use in NSCLC.