bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficacy and safety of moderate-intensity rosuvastatin plus ezetimibe versus high-intensity rosuvastatin monotherapy in the treatment of composite cardiovascular events with hypercholesterolemia: A meta-analysis
Authors: Liu Lingyan , Deng Yongkun , Li Lei , Yang Xingbiao , Yin Zhaoheng , Lai Yong 
Published: November 2024

Background
Statins are the gold standard in the treatment of dyslipidemia, significantly reducing the risk of cardiovascular disease.

Objective
To systematically review the efficacy and safety of Moderate-intensity Rosuvastatin Plus Ezetimibe compared with High-intensity Rosuvastatin in treating Composite Cardiovascular Events.

Methods
PubMed, Embase, Cochrane Library, CINAHL, Web of Science, China Knowledge Network, China Biological Literature Database, Wan Fang Database, and Weipu Database were searched to retrieve randomized controlled trials assessing the safety and efficacy of the two therapies from the time of construction to December 2023. The Jadad scale assessment tool was used to evaluate the quality of the included literature, and Review Manager 5.4 software was used for meta-analysis. The heterogeneity of outcomes was estimated by the I2 test, where we applied risk ratios (RR) and 95% confidence intervals (CI) to assess dichotomous outcomes and mean difference (MD) and 95% CI to present continuous outcomes. We used funnel plots to assess study publication bias and sensitivity analysis was used to address significant clinical heterogeneity.

Results
The meta-analysis described 21 RCTs involving 24592 participants. The findings indicated that moderate-intensity statin combination therapy improved low-density lipoprotein cholesterol (LDL-C) (MD -8.06, 95% CI [-9.48, -6.64] p < 0.05), total cholesterol (TG) (MD -5.66, 95% CI [-8.51, -2.82] p < 0.05), and non-high-density lipoprotein cholesterol (non-HDL-C) (MD -17.04, 95% CI [-29.55, -4.54] p < 0.05) to a greater extent and superior in achieving LDL-C <70 (RR1.26, 95% CI [1.22, 1.29] p < 0.05) and LDL-C <55 (RR1.66, 95% CI [1.56, 1.77] p < 0.05) ratios and in the incidence of adverse events than the high-intensity Rosuvastatin monotherapy group. However, there was no statistical difference between the two in improving HDL-C, total cholesterol (TC), and preventing long-term composite adverse cardiovascular events (ACE). Funnel plots indicated publication bias. Sensitivity analysis suggested instability in long-term composite cardiovascular events, HDL-C, and TC results.

Conclusions
Moderate-intensity statin plus ezetimibe with combination therapy had better efficacy and safety than high-intensity statins. Future validation is needed with more long-term high-quality large samples.
Age at diagnosis of diabetes, obesity, and the risk of dementia among adult patients with type 2 diabetes
Authors: Qi Xiang , Zhu Zheng , Luo Huabin , Schwartz Mark D. , Wu Bei 
Published: November 2024

Background
While Type 2 Diabetes Mellitus (T2DM) prevalence is increasing among younger individuals, few studies have examined how age at T2DM diagnosis relates to dementia risk in diabetic populations. We aimed to investigate the association between age at T2DM diagnosis and subsequent dementia risk, and to determine whether obesity moderates this relationship.

Methods
We conducted a prospective cohort study using data from the Health and Retirement Study (2002–2016) matched with its 2003 Diabetes Mail-Out Survey. The study included 1,213 dementia-free adults aged ≥50 with diagnosed T2DM. Primary exposures were age at T2DM diagnosis (categorized as <50, 50–59, 60–69, and ≥70 years) and obesity status (BMI ≥30 kg/m2). The outcome was incident dementia, assessed using the Telephone Interview for Cognitive Status. Cox proportional hazards models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs), adjusting for sociodemographic factors, health behaviors, health status, and diabetes medication use.

Results
Over a median follow-up of 10 (interquartile range, 6–14) years, 216 (17.8%) participants developed dementia. Compared to participants diagnosed with T2DM at age ≥70 years, those diagnosed at younger ages had increased dementia risk: HR 1.70 (95% CI, 1.03–2.80) for 60–69 years, 1.72 (95% CI, 1.06–2.79) for 50–59 years, and 1.90 (95% CI, 1.14–3.18) for <50 years. Obesity significantly moderated this relationship, with obese individuals diagnosed with T2DM before age 50 showing the highest dementia risk (HR 3.05; 95% CI 1.23–7.56) compared to non-obese individuals diagnosed at ≥50 years.

Conclusions
Younger age at diagnosis of T2DM was significantly associated with a higher risk of dementia, particularly among individuals with obesity. Interventions specifically targeting obesity may be more effective in preventing dementia for adults with a younger onset of T2DM.
Using large administrative data for mining patients’ trajectories for risk stratification: An example from urological diseases
Authors: Koh Harvey Jia Wei , Gašević Dragan , Rankin David , Frydenberg Mark , Talic Stella 
Published: November 2024

Objective
To identify latent clusters among urological patients by examining hospitalisation rate trajectories and their association with risk factors and outcome quality indicators.

Materials and methods
Victorian Admitted Episodes Dataset, containing information on all hospital admissions in Victoria from 2009 to 2019. The top twenty ICD-10 primary diagnosis codes in urology were used to select patients (n = 98,782) who were included in the study. Latent class trajectory modelling (LCTM) was used to cluster urological patient hospitalisation trajectories. Logistic regression was used to find baseline factors that influence cluster membership, the variables tested included comorbidities, baseline diagnosis codes, and socio-demographic factors. The analysis was further stratified into non-surgical procedures and surgical procedures.

Results
Five clusters of hospitalisation trajectories were identified based on clustering hospitalisation rates over time. Higher hospitalisation clusters were strongly associated with longer length of stay, higher readmission rates and higher complication rates. Higher-risk groups were strongly associated with comorbidities such as renal disease and diabetes. For surgical procedures, urological cancers (kidney, prostate and bladder cancer) and irradiation cystitis were associated with higher-risk groups. For non-surgical procedures, calculus of the bladder, urethral stricture and bladder neck obstruction were associated with higher-risk groups. For patients with two or more admissions, liver cardiovascular disease and being diagnosed with benign prostatic hyperplasia were also associated with higher risk groups.

Conclusion
A novel statistical approach to cluster hospitalisation trajectories for urological patients was used to explore potential clusters of patient risks and their associations with outcome quality indicators. This study supports the observation that baseline comorbidities and diagnosis can be predictive of higher hospitalisation rates and, therefore, poorer health outcomes. This demonstrates that it is possible to identify patients at risk of developing complications, higher length of stay and readmissions by using baseline comorbidities and diagnosis from administrative data.
Physical and occupational therapy service delivery models for populations identified as hard-to-reach: A scoping review
Authors: Noguchi Kenneth S. , Masrur Muhib , Letts Lori , Sinclair Susanne , Wojkowski Sarah , Richardson Julie 
Published: November 2024

Background
The delivery of rehabilitation services for hard-to-reach populations (e.g., refugees) is highly complex. There is a need for evidence-based approaches to deliver physiotherapy (PT) or occupational therapy (OT) services to this underserved group.

Objectives
The purpose of this scoping review was to identify PT and OT service delivery models that have been implemented, for populations typically identified as hard-to-reach and their associated health outcomes.

Eligibility criteria
Articles were eligible if they described PT and/or OT services for hard-to-reach populations. There were no restrictions on study design.

Study selection
Six electronic databases (AMED, CINAHL, MEDLINE, EMBASE, Healthstar, and PsycINFO) were searched from January 2000 to June 2023. Articles were screened in duplicate by two independent reviewers, and conflicts were resolved by consensus.

Results
Twenty-one articles with variable sample sizes (min, max n = 3 to 237) were included and detailed PT and/or OT services for immigrants/migrants, refugees, hard-to-reach veterans, people experiencing homelessness, lower incomes, trauma/torture, and those living in rehabilitation-deficient areas. Common rehabilitation needs (e.g., clinician to client connectivity), barriers (e.g., high transportation costs) and facilitators (e.g., encouragement) were identified among the various populations, mainly due to intersecting identities such as those who are both traumatized and refugees. Unique factors pertaining to the PT and OT services were also identified in some groups, including access to child and family services for people experiencing homelessness.

Conclusions
Despite common and individual needs, barriers, and facilitators in hard-to-reach groups in the literature, there is a need for studies with larger sample sizes, rigorous methodology and a conscious effort to publish the results of interventions to generate stronger recommendations for practice.
Pimicotinib Significantly Improves Outcomes for Patients with Tenosynovial Giant Cell Tumor
Authors:   Sunvalley Communication, LLC / Onco'Zine, Hofland Peter 
Published: November 2024

Results from the Phase 3 MANEUVER trial (NCT05804045) of pimicotinib (ABSK021), an investigational orally administered, highly selective, and potent small-molecule inhibitor of colony-stimulating factor-1 receptor (CSF-1R) being developed by Abbisko Therapeutics, met its primary endpoint, demonstrating significant improvement in objective response rate (ORR) in patients with tenosynovial giant cell tumor (TGCT). The ORR for pimicotinib at week 25 was 54.0% compared with 3.2% for placebo (p<0.0001).
O fracasso escolar: uma proximação cognitivista
Authors: Pagotti Antonio Wilson 
Published: November 2024

[...] A psicologia genética postula que o desenvolvimento ocorre por etapas evolutivas: primeiro, sensório-motora; posteriormente, pré-operacional; depois, operacional-concreta, e, finalmente, operacional-formal. No período de operações concretas, que tem início em torno dos 7 anos de idade, a criança é capaz de compreender a conservação de número, de quantidades contínuas e descontínuas, de peso, área e mesmo de volume. Consegue também fazer classificações utilizando as diversas leis de agrupamentos lógicos. A forma de raciocínio predominante é a indutiva, a criança faz generalizações a partir de situações concretas.
Em termos gerais, a criança com aproximadamente 9 anos, apresenta um relativo equilíbrio quanto ao pensamento concreto. Aos 11 ou 12 anos há um avanço para o período de operações formais, onde o raciocínio é hipotético-dedutivo, ou seja, o aluno pane das possibilidades, experimenta, variando as ateimavas, e conclui. Nesse sentido, ela já é capaz de abstrações de ordem puramente verbal, já consegue trabalhar com as noções de proporcionalidade, sistema combinatório e controlar variáveis [...]

Palavras-chave: Cognitiva; Escolar; Fracasso; Psicologia; Etapas evolutivas.
O Geógrafo: Atividades e mercado de trabalho
Authors: Rosa Roberto 
Published: November 2024

[...] O Conselho Nacional de Geografia foi criado pelo decreto 1527, de 24 de março de 1937, poucos anos depois da criação dos primeiros cursos universitários de geografia e da Associação dos Geógrafos Brasileiros (1934). Porém, o profissional técnico em geografia não teve a merecida atenção por parte dos órgãos governamentais, não tendo sido reconhecida e nem regulamentada a profissão. O reconhecimento da profissão de geógrafo só foi se dar em junho de 1979, através da Lei n? 6.664. Tal reconhecimento legal da profissão foi resultado de uma longa luta levada a efeito principalmente através da Associação dos Geógrafos Brasileiros.
Segundo esta lei, "Art . 3 É da competência do Geógrafo o exercício das seguintes atividades e funções a cargo da União, dos Estados, dos Territórios e dos Municípios, das entidades autárquicas ou de economia mista e particulares: I — reconhecimento, levantamento, estudos e pesquisas de caráter físico-geográfico, biogeográfico, antropogeográfico e geoeconômico e as realizadas nos campos gerais e especiais da Geografia, que se fizerem necessárias [...]

Palavras-chave: Geografia; Cursos Universitários; Munícipios; Trabalho; Profissão.
Quem são os alunos repetentes da primeira série do primeiro grau do município de Uberlândia
Authors: Andrade Antonio dos Santos 
Published: November 2024

[...] O presente artigo é parte de uma tese de Doutorado onde se pretendeu um estudo etnográfico com alunos repetentes da primeira série do primeiro grau. Os dados que serão apresentados aqui foram obtidos na primeira fase do estudo a esta seguiram-se um levantamento do potencial cognitivo dos alunos e um estudo da instituição escolar através da observação participante. Os dados a serem apresentados a seguir referem-se ao que temos denominado como "contextualização", procedimento de pesquisa adotado com o objetivo de caracterizar as origens socioeconômica e cultural dos alunos, que inclui entrevistas com os familiares, visitas ao local de moradia, observações durante a entrevista e fora dela. Estudos anteriores (Wolf, 1978; Gatti, 1981; Arns, 1978; Isaac, 1977; Ferrari, 1975; Bonamigo, 1980; Fukui, 1980 e Rosemberg, 1981) indicam que as crianças provenientes das classes socioeconômicas inferiores são as mais vitimadas pela repetência e evasão nas primeiras' séries escolares. Nesta etapa de nossa tese, pretendemos verificar, a partir de um estudo mais intensivo com uma amostra representativa dos alunos repetentes de uma escola estadual do município de Uberlândia, a confirmação dos resultados citados. [...]

Palavras-chave: Munícipio; Uberlândia; Alunos; Primeiro grau; Primeira fase.
Da ideologia: Para o exorcismo de um instrumento de análise.
Authors: Araújo Jose Carlos S. 
Published: November 2024

[...] Gestada durante séculos, desde a alta Idade Média, uma nova concepção de homem e de mundo chega à maturidade no século XIX. Uma nova ordem se estabelece: as ideias culturalmente liberalizantes geraram o denominado liberalismo; por sua vez, este se tornou o parâmetro por excelência de e para uma nova ordenação jurídica da sociedade: o capitalismo, o Estado Moderno, a ciência, a religião, a educação, a saúde, a cultura, etc. Tudo veio a passar pelo crivo do ideário liberal. Tudo é permeado por ele. É um referencial antropologizante novo e um novo modo de compreender o homem e o mundo: o individualismo, a igualdade, a liberdade, o contrato (enquanto mediação fundamental das relações humanas), a tolerância e a propriedade são categorias assumidas como valores naturais e fundamentais da existência humana e da sociedade. Esse edifício novo veio sendo construído no interior mesmo do antigo, à medida que as implosões culturais se fizeram necessárias, tendo em vista uma utopia que a tudo contagiava [...]

Palavras-chave: Ideologia; Exorcismo; Instrumento; Análise; Idade média.
Die Theologischen Traktate - A.M.S Boethius
Authors: Tannus Marcio Chaves- 
Published: November 2024

ANICIUS MANLIUS SEVERINUS BOETHIUS, executado no ano de 524 de nossa era, a mando de TEODORICO, rei bárbaro do império romano do ocidente, então em fase final de decadência, é considerado o último dos filósofos romanos e o primeiro dos escolásticos. Sua obra mais conhecida, escrita nos últimos meses de vida, à espera da morte, traz o título de "De consolatione philosophiae". o significado histórico e filosófico do conjunto da obra de BOÉCIO é imenso e não se limita ao fato, já por si suficiente, de ter sido a mais importante fonte de transmissão da lógica aristotélica à Idade Média [...]
A segurança em Descartes
Authors: Macedo Leosino Bizinoto 
Published: November 2024

Rios de tinta verteram já, ao longo dos últimos séculos, sob fona de interpretação, análise e crítica ao cartesianismo dificultando, assim, nosso propósito de originalidade. Se, por essa razão, não conseguimos lograr algum mérito no tocante à originalidade temática, pelo menos algum valor terá a criação do neologismo evidenciado no decorrer deste trabalho. Tal neologismo soará para o leitor como algo novo até que a etimologia deite abaixo nossa glória efêmera: asfalemania. Do grego asfalé, que quer dizer segurança; mais a palavra também grega mania, que significa aferro habitual, mania, obsessão. Muitos estudiosos de Descartes chegam a achar exagerada, obsessiva até, sua preocupação com a segurança. Tal fato despenou-nos para breve estudo do assunto, demarcado pelas questões que ora propomos: que significados tem a palavra segurança? que amplitude os textos cartesianos nos autorizam a lhe dar? quais posturas assumidas ao longo de sua vida revelam, de fato, aquela obsessão? e quais as causas dessa preocupação? [...]
Palavras-chave: Descartes; Segurança; Estabilidade; Constância; Circunspecção.
O Despertar da Esfinge: O sentimento trágico de Antero de Quintal e de Miguel de Unamuno
Authors: Caporalini José Belluci 
Published: November 2024

Ao escrevemos sobre o sentimento trágico de Antero de Quental e de Miguel de Unamuno tínhamos um propósito: mediatamente conhecermos mais profundamente ambos autores ibéricos; imediatamente contemplamos a alma ibérica, e muito em particular a lusa, através da influência de Antero sobre Unamuno, ou seja, o sentimento trágico da vida daquele sobre este. Antero e Unamuno seguiram caminhos semelhantes, tiveram ideias paralelas, típicas de suas respectivas gerações e usaram o método dialético. Ambos eram homens de crise vivendo numa época de crise. Apesar de tanto parentesco ideológico existencial, pouco ou quase nada se falou da influência de Antero sobre Unamuno e do paralelismo de seus escritos. Ambos, também, perderam a fé, quando estudantes universitários, mas jamais conseguiram se livrar da ideia de Deus recebida na infância. Daí que a sua obra literária será de cunho transcendente, religioso e ar é onde reside a origem do sentimento trágico na vida de ambos vates. Antero não abandona a ideia de santidade e Unamuno insiste constantemente na imortalidade do homem de came e osso. [...]
Palavras-chave: Esfinge; Antero de Quintal; Miguel de Unamuno; Método dialético; Ideologia.
Zgoda na udzielanie świadczeń medycznych wyrażona przez pacjenta w silnym bólu a wyłączenie swobody podjęcia decyzji w rozumieniu art. 82 Kodeksu cywilnego
Authors: Fajka Dominika 
Published: November 2024

Praca ma na celu omówienie prawa pacjenta do leczenia bólu i prawa do wyrażenia zgody na udzielenie świadczenia zdrowotnego, a także ocenę relewantności prawnej zgody na udzielenie takiego świadczenia, wyrażonej przez pacjenta odczuwającego ból, w odniesieniu do ewentualnego ograniczenia lub wyłączenia swobody podjęcia decyzji w rozumieniu art. 82 Kodeksu cywilnego (k.c.), przy uwzględnieniu aspektów praktycznych realizacji tych praw oraz z uwzględnieniem obowiązków lekarza. Należy bowiem uznać, że stan psychofizyczny, w którym znajduje się pacjent odczuwający silny ból, może być postrzegany jako stan wyłączający swobodę powzięcia decyzji w rozumieniu art. 82 k.c., a co za tym idzie – może mieć znaczący wpływ na ważność udzielonej zgody.
Total Recall
Authors: Gebel Tobias , Hense Andrea , Schork Franziska 
Published: November 2024

Zusammenfassung
Der Beitrag untersucht Recalls im Prozess der öffentlichen Arbeitsvermittlung und der Reintegration in den deutschen Arbeitsmarkt. Recalls sind eine spezifische Form der diskontinuierlichen Beschäftigung, die sich dadurch auszeichnet, dass ehemalige Arbeitskräfte zu einem späteren Zeitpunkt durch ihren früheren Arbeitgeber wiederbeschäftigt werden. Im Mittelpunkt unserer explorativen Analysen stehen die Fragen nach den Bedingungen, unter denen Recall-Optionen im Vermittlungsgespräch verfolgt werden, nach den Aktivitäten zur Förderung bzw. Verwerfung von Recall-Strategien und nach den Erwartungen von Arbeitssuchenden an Recalls im Vermittlungsprozess. Als Datengrundlage standen uns vollständig transkribierte Vermittlungsgespräche des Instituts für Arbeitsmarkt- und Berufsforschung (IAB) zur qualitativen Sekundäranalyse zur Verfügung. Die Ergebnisse zeigen, dass Recalls insbesondere dann in Betracht gezogen werden, wenn ein Vertrauensverhältnis zum ehemaligen Arbeitgeber über den Betriebsaustritt hinaus besteht und über bestehende Betriebskontakte Konkurrenzvorteile erhofft werden. Mit dem Recall ist die Erwartung verbunden, die Arbeitslosigkeit schneller beenden und finanziellen Einbußen entgegenwirken zu können. Zudem wird diese Option in Betracht gezogen, wenn Beschäftigungsalternativen nur eingeschränkt zur Verfügung stehen. Die Vermittlungsfachkraft fördert Recalls besonders dann, wenn sie die Reintegration in den Arbeitsmarkt durch einen Recall als aussichtsreicher einschätzt als alternative Angebote. Insgesamt verweisen die Ergebnisse darauf, dass Recalls im Prozess der öffentlichen Arbeitsvermittlung sowie auf dem deutschen Arbeitsmarkt eine relevante Beschäftigungsoption darstellen.
Geopolitical Risks and Stock Market Volatility in the SAARC Region
Authors: Panazan Oana , Gheorghe Catalin , Calefariu Emilia 
Published: November 2024

Abstract
This study examined the stock market volatility of the member states of the South Asian Association for Regional Cooperation (SAARC) and geopolitical risk (GPR). The analysis period covered January 2014 to March 2024, and the time–frequency wavelet method was used to process the data. The time-varying parameter vector autoregression and spatial autoregressive models helped determine the dynamic connectedness of volatility in the analyzed states. The findings revealed similar stock market connections in Bangladesh and India. In addition, a comparative analysis of stocks in India and Pakistan led to the identification of common elements. The connection between geopolitical concerns and Sri Lankan stocks was the strongest and increased in intensity after 2019. GPR and Nepal’s stock market maintained a continuous but low-intensity relationship. The dynamic connectedness between member states’ stock markets was limited during the review period. The study results could encourage SAARC governments to bridge their political differences to ensure that South Asia becomes a strong partner in the global economy. Equally, our results can benefit investors, financial institutions, regulatory authorities, and governments.