bluuebunny/crossref_metadata_2025_split huggingface dataset:
OpenMICE: an open spatial and temporal data set of small mammals in south‐central Italy based on owl pellet data
Authors: Paniccia Chiara , Di Febbraro Mirko , Delucchi Luca , Oliveto Rocco , Marchetti Marco , Loy Anna 
Published: September 2018

AbstractThe use of database technologies as a tool for implementing data for quantitative ecological studies and biodiversity conservation planning has recently attracted the attention of the biological community. Despite the fact that the number of biodiversity data sets is quickly rising, online databases of small mammals are still scarce, especially for Mediterranean ecosystems. We implemented the first standardized and accessible georeferenced European database of small mammal occurrences, abundances, and functional traits. Data derived from owl pellets was obtained from different sources, including original field surveys, publications, gray literature, existing databases, and museum collections. The OpenMICE database covers the years 1972 to 2017 and includes nearly 50,000 individuals from 23 species (13 Rodentia and 10 Eulipotyphla) at 190 sites in south‐central Italy. Our specific goals in compiling this data set were as follows: (1) to make data that is usually accessible to a restricted audience widely available; (2) to identify the gaps in knowledge about small mammal communities and guide future sampling and conservation efforts; and (3) to gain a first insight into small mammal diversity and abundance in the study area. The potential applications of our spatial relational database are many, from individual‐based to community‐based models as potential indicators of environmental changes at different geographical scales. Given the long‐term support for data storage, the OpenMICE database could be further expanded to include other geographical contexts and implemented with new information and traits. We would appreciate that researchers cite this paper if using all or part of the data set. We also request that researchers and teachers inform us of how they are using the data. We intend to keep it up to date as novel studies become available (see Data Availability).
Dynamics of partially obstructed breakup of bubbles in microfluidic Y‐junctions
Authors: Ziyi Xu , Taotao Fu , Chunying Zhu , Shaokun Jiang , Youguang Ma , Kai Wang , Guangsheng Luo 
Published: September 2018

AbstractFor revealing the dynamics of partially obstructed breakup of bubbles in microfluidic Y‐junctions, the combination of dimensionless power‐law and geometric model was applied to study the effects of capillary number, bubble length, and channel angle on the bubble rupture process. In the squeezing process, the gas‐liquid interface curve follows the parabolic model. For the evolution of the bubble neck during breakup, the increase of the bubble length, the channel angle, and the capillary number leads to the decrease of the focus distance α. The chord m increases with the increase of the capillary number and the decrease of the bubble length, and it would reach the maximum value when the channel angle is 90°. In the fast pinch‐off stage during bubble breakup, the bubble's neck curve no longer conforms to the parabolic model so the focus and chord no longer exist. For the evolution of the bubble head during breakup, the value of γ approaches 1 with the increase of the capillary number and the bubble length, and with the close of the channel angle to 90°. It is found that the quadrilateral model can be applied for the partially obstructed rupture of bubbles in the symmetrical microfluidic Y‐junction.
Automated co‐registration and calibration in SfM photogrammetry for landslide change detection
Authors: Peppa Maria V. , Mills Jon P. , Moore Phil , Miller Pauline E. , Chambers Jonathan E. 
Published: September 2018

AbstractLandslides represent hazardous phenomena, often with significant implications. Monitoring landslides with time‐series surface observations can indicate surface failure. Unmanned aerial vehicles (UAVs) employing compact digital cameras, in conjunction with structure‐from‐motion (SfM) and multi‐view stereo (MVS) image processing approaches, have become commonplace in the geoscience research community. These methods offer relatively low‐cost, flexible solutions for many geomorphological monitoring applications. However, conventionally ground control points (GCPs) are required for registration purposes, the provision of which is often expensive, difficult or even impracticable in hazardous and inaccessible terrain.In an attempt to overcome the reliance on GCPs, this paper reports research that has developed a morphology‐based strategy to co‐register multi‐temporal UAV‐derived products. It applies the attribute of curvature in combination with the scale‐invariant feature transform algorithm, to generate time‐invariant curvature features, which serve as pseudo‐GCPs. Openness, a surface morphological digital elevation model derivative, is applied to identify relatively stable ground regions from which pseudo‐GCPs are selected. A sensitivity threshold quantifies the minimum detectable change alongside unresolved biases and misalignment errors. The approach is evaluated at two study sites in the UK, first at Sandford with artificially induced surface change, and second at an active landslide at Hollin Hill, with multi‐epoch SfM‐MVS products derived from a consumer‐grade UAV. Elevation changes and annual displacement rates at dm‐level are estimated, with optimal results achieved over winter periods. The morphology‐based co‐registration strategy resulted in relative error ratios (i.e. mean error divided by average flying height) in the range 1:800–2500, comparable with those reported by similar studies conducted with UAVs augmented with real time kinematic (RTK)‐Global Navigation Satellite Systems. Analysis demonstrates the potential of the morphology‐based strategy for a semi‐automatic, and practical co‐registration approach to quantify surface motion. This can ultimately complement geotechnical and geophysical investigations and support the understanding of landslide behaviour, model prediction and construction of measures for mitigating risks. © 2018 John Wiley & Sons, Ltd.
Prediction of immunoglobulin M reduction via therapeutic dose of simple plasma exchange and double filtration plasmapheresis using membrane separation in patients with hyperviscosity syndrome caused by Waldenstrom macroglobulinemia
Authors: Miyamoto Yoshihisa , Hamasaki Yoshifumi , Matsumoto Akihiko , Doi Kent , Noiri Eisei , Nangaku Masaomi 
Published: September 2018

Abstract
Background: Plasma exchange (PE) and double filtration plasmapheresis (DFPP) are known as effective treatment options for hyperviscosity syndrome (HVS) caused by Waldenstrom macroglobulinemia. Nonetheless, few data are available for the relation between the prescribed dose of apheresis and the reduction rate of target molecule immunoglobulin M (IgM), especially in the modality using membrane separation.
Objectives: This study was conducted to establish a model to predict the IgM reduction rate by the dose of simple PE and DFPP using membrane separation in patients with HVS and to compare the consumption of albumin between PE and DFPP.
Methods: We retrospectively analyzed data of total 17 sessions of PE and DFPP with various therapeutic doses performed for five patients at our institution. We used linear regression analysis to examine the relation between the ratio of processed plasma volume to estimated circulating plasma volume (X) and the reduction rate of IgM (Y).
Results: Regression analysis revealed that Y is expressed by X as the following equation: Y = 0.35X + 0.095. The total usage of albumin for replacement fluid was lower in DFPP than in PE (21.5 g vs 150 g per session), although the treatment efficacies of both modalities are similar.
Conclusion: The dose of PE and DFPP using membrane separation can predict IgM reduction rate in the HVS patients. Predicted IgM reduction rates based on our model are lower than those calculated using a known theoretical model. In terms of the amount of use of albumin, DFPP is preferred to PE.
Long noncoding RNA opa‐interacting protein 5 antisense transcript 1 promotes proliferation and invasion through elevating integrin α6 expression by sponging miR‐143‐3p in cervical cancer
Authors: Yang Jing , Jiang Bo , Hai Jing , Duan Shufeng , Dong Xuecai , Chen Caixia 
Published: September 2018

AbstractAn increasing number of studies have shown that long noncoding RNAs (lncRNAs) play important roles in cervical cancer (CC) progression. However, the roles and underlying mechanisms of lncRNA opa‐interacting protein 5 antisense transcript 1 (OIP5‐AS1) involved in the CC remain unclear. In the current study, we found that lncRNA OIP5‐AS1 was upregulated in CC tissues and cell lines. High OIP5‐AS1 expression was significantly correlated with advanced International Federation of Gynecology and Obstetrics (FIGO) stage, lymph node metastasis, and poor overall survival of patients with CC. Using in vitro function assays, we showed that OIP5‐AS1 suppression significantly decreased the proliferation, colony formation, and invasion ability of CC cells. Moreover, we revealed that OIP5‐AS1 could act as a competing endogenous RNA of miR‐143‐3p to regulate the ITGA6 expression. Rescue assays showed that miR‐143‐3p inhibitors or ITGA6 overexpression could reverse the inhibitory effects of OIP5‐AS1 suppression on the proliferation and invasion in CC cells. In addition, OIP5‐AS1 suppression reduced tumor growth in vivo. In conclusion, we demonstrated that OIP5‐AS1 promoted proliferation and invasion of CC cells via increasing the ITGA6 expression by sponging miR‐143‐3p, which might be an effective therapeutic target for the treatment of patients with CC.
Allyl rhodanine azo dye derivatives: Potential antimicrobials target d‐alanyl carrier protein ligase and nucleoside diphosphate kinase
Authors: Abou‐Dobara Mohamed I. , Omar Noha F. , Diab Mostafa A. , El‐Sonbati Adel Z. , Morgan Shaimaa M. , El‐Mogazy Mohammed A. 
Published: September 2018

Abstract3‐Allyl‐5‐(4‐arylazo)‐2‐thioxothiazolidine‐4‐one (HLn) ligands (where n = 1 to 3) were hypothesized to have antimicrobial activities mediated through inhibition of new antimicrobial targets. The ligands (HLn) were synthesized and characterized by infrared (IR) and 1H nuclear magnetic resonance (1H NMR) spectra. The ligands (HLn) were in silico screened to their potential inhibition to models of d‐alanyl carrier protein ligase (DltA) (from Bacillus cereus, PDB code 3FCE) and nucleoside diphosphate kinase (NDK) (from Staphylococcus aureus; PDB code 3Q8U). HL3 ligand has the best energy and mode of binding to both NDK and DltA, even though its binding to DltA was stronger than that to NDK. In antimicrobial activity of HL3 ligand, morphological and cytological changes in HL3‐treated bacteria agreed with the in silico results. The HL3 ligand showed significant antimicrobial activity against B. cereus, S. aureus, and Fusarium oxysporium. The HL3‐treated bacterial cells appeared malformed and incompletely separated. Its cell walls appeared electron‐lucent and ruptured. They contained more mesosomes than normal cells. It was found that the HL3 ligand represented as a bactericide against B. cereus and S. aureusby blocking target DltA, and may target NDK.
Quercetin‐mediated regulation of signal transduction cascades and microRNAs: Natural weapon against cancer
Authors: Farooqi Ammad Ahmad , Jabeen Saima , Attar Rukset , Yaylim Ilhan , Xu Baojun 
Published: September 2018

AbstractRecent technological and analytical breakthroughs in genomics and proteomics have deepened our understanding related to the multifaceted nature of cancer. Because of therapeutically challenging nature of cancer, there has been a renewed interest in phytochemistry, and much attention is currently being given to the identification of signaling pathway inhibitors. Data obtained through high‐throughput technologies has provided a broader landscape of wiring maps of complex oncogenic signaling networks, thus revealing novel therapeutic opportunities. Increasingly, it is being realized that although our knowledge related to physiological and pathophysiological roles of signal transduction cascades has evolved rapidly, the clinical development of signaling pathway inhibitors has been challenging. Quercetin has attracted considerable attention because of its amazingly high pharmacological value. Research over decades has sequentially shown that quercetin effectively inhibited cancer development and progression. In this review, we have attempted to set the spotlight on the regulation of different cell signaling pathways by quercetin. We partition this multicomponent review into how quercetin effectively regulates the Wnt/β‐catenin pathway, Janus kinase‐signal transducer and activator of transcription pathway, and vascular endothelial growth factor/vascular endothelial growth factor receptor signaling cascade in different types of cancers. We also provide an overview of the regulation of NOTCH and SHH pathways by quercetin. MicroRNAs (miRNAs) have also emerged as versatile regulators of cancer, and contemporary studies have shed light on the ability of quercetin to control different miRNAs in various cancers. We have scattered information related to NOTCH and SHH pathways, and future studies must converge on the investigation of these pathways to see how quercetin modulates the signaling machinery of these pathways.
Chemerin induces lipolysis through ERK1/2 pathway in intramuscular mature adipocytes of dairy bull calves
Authors: Fu Yuan‐Yuan , Hu Bian‐Hong , Chen Kun‐Lin , Li Hui‐Xia 
Published: September 2018

AbstractThe adipokine Chemerin has been reported to regulate differentiation and metabolism of adipocytes, but the mechanism underlying lipolysis is still largely unknown. The purpose of this study was to explore whether ERK1/2 pathway is involved in regulating Chemerin during bovine intramuscular mature adipocyte lipolysis. Intramuscular mature adipocytes of dairy bull calves were cultured in vitro and were treated with Chemerin or U0126, which is an inhibitor of ERK1/2 pathway. The results showed that TG content in cells was significantly decreased, glycerol and free fatty acid were significantly increased in cell culture media, and the expression of phosphorylated ERK1/2 in cells was increased in Chemerin‐treated group, suggested that ERK1/2 pathway was involved in regulation of lipolysis by Chemerin. In addition, the expression of lipolytic‐related critical factors ATGL, HSL, LPL, PPARα, UCP3, and CPT1 were upregulated, but the expression of adipogenic key factors, including PPARγ and C/EBPα were downregulated by Chemerin. Interestingly, all the effects of Chemerin on genes expression in intramuscular mature adipocytes or fat tissue were inhibited by U0126, showed that the function of Chemerin to promote adipose decomposition will be significantly weakened if the ERK1/2 pathway is suppressed, and confirmed that ERK1/2 pathway is involved in mediate Chemerin‐enhanced lipolysis. In conclusion, the study demonstrated that Chemerin induce intramuscular mature adipocytes lipolysis through activation of the ERK1/2 pathway. Our research at least provide partial mechanisms of Chemerin on lipolysis and deposition of intramuscular fat tissue of dairy bull calves.
MicroRNA‐424 regulates epithelial‐mesenchymal transition of endometrial carcinoma by directly targeting insulin‐like growth factor 1 receptor
Authors: Shu Shanrong , Liu Xiaoping , Xu Ming , Gao Xuesong , Fan Jin , Liu Huan , Li Ruiman 
Published: September 2018

AbstractAlthough numerous miRNAs are reported to contribute to the carcinogenesis of malignant tumor, the specific role of miR‐424 in endometrial carcinoma is seldom reported. To explore the effect of miR‐424 on epithelial‐mesenchymal transition and its underlying mechanism, we detected miR‐424 expression in endometrial carcinoma tissue and cells. We found that miR‐424 was significantly downregulated in endometrial carcinoma tissues and cells, especially in HEC‐1B cells. To perform the functional analysis, we transfected HEC‐1B with miR‐424‐mi, miR‐424‐inh, mi‐control, and inh‐control, respectively. We found that overexpression of miR‐424 significantly decreases cell proliferation and migration, accompanied with the increased E‐cadherin/Vimentin expression and the transition of mesenchymal to epithelial cell phenotype. We identified that insulin‐like growth factor‐1 receptor (IGF‐1R) was a potential target of miR‐424 by computational analysis followed by luciferase reporter assays. Of note, we found that the downregulation of miR‐424 in HEC‐1B cells enhanced endogenous IGF‐1R expression. Further mechanistic analysis revealed that forced expression of IGF‐1R in miR‐424‐mim transfected cells remedied the weakened migration resulting from overexpression of IGF‐1R. Taken together, the results of the current study demonstrated that miR‐424 was a tumor suppressor for endometrial carcinoma and a favorable factor against tumor progression through targeting IGF‐1R, thus providing a target for the treatment of endometrial carcinoma.
Role of green tea catechins in prevention of age‐related cognitive decline: Pharmacological targets and clinical perspective
Authors: Farzaei Mohammad Hosein , Bahramsoltani Roodabeh , Abbasabadi Zahra , Braidy Nady , Nabavi Seyed Mohammad 
Published: September 2018

AbstractOver the past decade, a wide range of scientific investigations have been performed to reveal neuropathological aspects of cognitive disorders; however, only limited therapeutic approaches currently exist. The failures of conventional therapeutic options as well as the predicted dramatic rise in the prevalence of cognitive decline in the coming future show the necessity for novel therapeutic agents. Recently, a wide range of research has focused on pharmacological activities of green tea catechins worldwide. Current investigations have clarified mechanistic effects of the catechins in inflammatory cascades, oxidative damages, different cellular transcription as well as transduction pathway in various body systems. It has been demonstrated that green tea polyphenols prevent age‐related neurodegeneration through improvement of endogenous antioxidant defense mechanisms, modulation of neural growth factors, attenuation of neuroinflammatory pathway, and regulation of apoptosis. The catechins exhibited beneficial effects in cellular and animal models of neurodegenerative diseases including Alzheimer’s disease, MS, and Parkinson’s disease. The present review discusses the current pharmacological targets, which can be involved in the treatment of cognitive decline and addresses the action of catechin derivatives elicited from green tea on the multiple neural targets.
Altered T‐cell subpopulations in recurrent pregnancy loss patients with cellular immune abnormalities
Authors: Abdolmohammadi Vahid Samaneh , Ghaebi Mahnaz , Ahmadi Majid , Nouri Mohammad , Danaei Shahla , Aghebati‐Maleki Leili , Mousavi Ardehaie Reza , Yousefi Bahman , Hakimi Parvin , Hojjat‐Farsangi Mohammad , Rikhtegar Reza , Yousefi Mehdi 
Published: September 2018

AbstractRecurrent pregnancy loss (RPL) is a multifactorial disorder of women in reproductive age, which in some cases is caused by immunologic abnormalities. In this study, we aimed to evaluate cellular and molecular components of the immune system like different T‐cell subsets and their regulating microRNAs (miRNAs) in RPL women and control group. Fifty RPL and 50 healthy subjects were recruited. Subsets of T cells, including regulatory T (Treg) cells, helper T (Th) 17 cells, exhausted T cells, exhausted Treg cells were evaluated by flow cytometry. Transcription factors of T cells and related miRNA profile were quantified using real‐time polymerase chain reaction (RT‐PCR). Assessment showed that Treg and exhausted T cells, were decreased in RPL patients (p = 0.009 and 0.02, respectively), while an increase was observed in Th17 and exhausted Treg frequency (
p = 0.013 and 0.0037, respectively). Messenger RNA expression level of
T‐bet and
IRF4 was upregulated in RPL patients (
p = 0.011 and 0.0001, respectively), while Th2‐ and Treg‐related transcription factors,
GATA3 and
GITR, were downregulated in these patients compared with the healthy subjects (
p = 0.0008 and <0.000, respectively). Treg‐associated miRNAs, the miR‐106b‐25–93 cluster, showed a higher rate in RPL patients (
P = 0.007, 0.001, and 0.029, respectively), however, we observed no significant difference in the expression level of Th17‐associated miRNA, mir‐326. According to the results, we concluded that unbalanced immune responses and deregulated function of T‐cell subsets may lead to reproduction‐related failure like a miscarriage. Therefore, evaluation of immune cells and related miRNA profile may serve as prognostic biomarker for the treatment of RPL patients.
Roles of microRNAs in preeclampsia
Authors: Lv Yan , Lu Cheng , Ji Xiaohong , Miao Zhijing , Long Wei , Ding Hongjuan , Lv Mingming 
Published: September 2018

AbstractPreeclampsia (PE) is a complex disorder that is characterized by hypertension and proteinuria after the 20th week of pregnancy, and it causes most neonatal morbidity and perinatal mortality. Most studies suggest that placental dysfunction is the main cause of PE. However, genetic factors, immune factors, and systemic inflammation are also related to the pathophysiology of this syndrome. Thus far, the exact pathogenesis of PE is not yet fully understood, and intense research efforts are focused on PE to elucidate the pathophysiological mechanisms. MicroRNAs (miRNAs) refer to small single‐stranded and noncoding molecules that can negatively regulate gene expression, and miRNA regulatory networks play an important role in diverse pathological processes. Many studies have confirmed deregulated miRNA in pregnant patients with PE, and the function and mechanism of these differentially expressed miRNA are gradually being revealed. In this review, we summarize the current research about miRNA involved in PE, including placenta‐specific miRNA, their predictive value, and their function in the development of PE. This review will provide fundamental evidence of miRNA in PE, and further studies are necessary to explore the roles of miRNA in the early diagnosis and treatment of PE.
Suppression of SEMA6C promotes preantral follicles atresia with decreased cell junctions in mice ovaries
Authors: Yan Wei , Zhou Su , Shen Wei , Cheng Jing , Yuan Suzhen , Ye Shuangmei , Jin Yan , Luo Aiyue , Wang Shixuan 
Published: September 2018

AbstractMammalian oocytes go through a long and complex developmental process, while acquiring the competencies that are required for fertilization and embryogenesis. Recent studies revealed that the communication between oocytes and granulosa cells (GCs) is a critical process for female follicle development. In the current study, we aimed to study whether and how semaphorin 6C (Sema6c) regulated the cell junctions between oocytes and GCs in mice preantral follicles. The attenuation of SEMA6C expression by siRNA decreased the cell–cell junctions and accelerated follicle atresia in vitro. PI3K‐AKT pathway was activated when SEMA6C expression was downregulated. And the LY294002, a PI3K inhibitor, could reverse the effect of low SEMA6C expression on cell junctions in preantral follicles. Our findings revealed that Sema6c was involved in follicle development, and the suppression of SEMA6C led to cell junction defection by activating the PI3K/AKT pathway, which might also provide valuable information for understanding premature ovarian failure and ovarian aging.