bluuebunny/crossref_metadata_2025_split huggingface dataset:
Asteriscus graveolens exhibits Antihypertensive Activity through Activation of Vascular KATP Channels Activation in Rats
Authors: El-Ouady Fadwa , Eddouks Mohamed 
Published: October 2019

Objective:
The objective of the study was to evaluate the antihypertensive activity of Asteriscus
graveolens.

Methods:
L-NAME hypertensive and normotensive rats have received orally the aqueous extract of
Asteriscus graveolens aerial parts (AGAPE) (100 mg/kg) during six hours for the acute experiment and
during seven days for the sub-chronic treatment. Thereafter, blood pressure parameters were evaluated.
Concerning the in vitro investigation, the vasorelaxant effect of AGAPE was tested in isolated thoracic
aortic rings.

Results:
AGAPE extract significantly decreased the blood pressure parameters in hypertensive rats.
Moreover, the results revealed that AGAPE exhibited antihypertensive effect through its vasorelaxant
properties. More interestingly, this vasorelaxant activity seems to be probably mediated through activation
of K+ ATP-sensitive (KATP) channels.

Conclusion:
The study demonstrates the antihypertensive activity of aqueous Asteriscus graveolens
extract in hypertensive rats through activation of vascular KATP channels. This finding supports the use
of this plant for the management of hypertension in Morocco.
Evaluation of Salivary Antioxidants and Oxidative Stress Markers in Type 2 Diabetes Mellitus: A Retrospective Cohort Study
Authors: Fathi Shima , Borzouei Shiva , Goodarzi Mohammad Taghi , Poorolajal Jalal , Ahmadi-Motamayel Fatemeh 
Published: October 2019

Background:
Diabetes Mellitus (DM) is a progressive metabolic disorder.

Objective:
The aim of this study was to investigate the relationship between antioxidant and oxidative
stress markers in the saliva of patients with type 2 DM and a healthy control group.

Methods:
In this study, 20 patients with diabetes and 20 healthy individuals were evaluated. Salivary
antioxidants markers consisted of total antioxidant capacity (TAC), uric acid (UA), peroxidase and
catalase. Oxidative stress markers included total oxidant status (TOS), malondealdehyde (MDA) and
total thiol (SH). Sialochemical analysis was performed with spectrophotometric assay. All the statistical
analyses were conducted using STATA software.

Results:
TAC decreased significantly in patients with diabetes. Although salivary UA and peroxidase
were lower in patients with diabetes compared to the control group, the difference was not significant.
Salivary catalase in patients with diabetes was significantly lower than that in the control group. MDA
and TOS exhibited significantly higher levels in type 2 DM. SH levels were slightly higher in DM.

Conclusions:
According to the results of the present study, there were some changes in the salivary
levels of some antioxidants and oxidative stress markers in patients with type 2 DM and could be
measured as an indicator of serum changes..
Arum conophalloides Aqueous Extract Induced Hepatotoxicity in Rat; Histopathological, Biochemical, and mir-122 Assessments
Authors: Derakhshanfar Amin , Moayedi Javad , Vahedi Mahjoob , Valizadeh Abouzar 
Published: October 2019

Background:
Arum conophalloides (A. conophalloides) is a wild edible delicate plant,
widely used in traditional medicine.

Objective:
This study aimed to examine the effects of A. conophalloides extracts on biochemical,
molecular, and histopathological changes in the rat.

Methods:
Fifty adult male Sprague-Dawley rats were divided into 5 groups (10 each) as follows: G1
or control, received distilled water; G2 and G3, treated with the aqueous extract at doses of 200 and
400 mg/kg; G4 and G5, treated with the hydroalcoholic extract at doses of 200 and 400 mg/kg. Prior
to and at the end of the experiments, the serum levels of biochemistry parameters and the relative expression
of miR-122 were assessed. Moreover, the liver and kidney tissues were examined microscopically.

Results:
Liver and kidney tissues showed normal structure in all groups. There were no significant
changes in biochemical indices or the expression of miR-122 in the extract-treated groups at the dose
of 200 mg/kg. However, the group that received the aqueous extract at the dose of 400 mg/kg exhibited
a significantly lower level of HDL, LDL, ALT, and ALP in comparison to the control. Additionally,
miR-122 expression in this group exhibited a 10-fold increase (P=0.009).

Conclusion:
The serum level of hepatocyte-specific miR-122 will be more helpful in detecting hepatic
changes in early stages than ALT and AST activity or histopathological evaluations of liver sections.
Our findings highlight the potential hepatotoxicity of A. conophalloides aqueous extract in a rat
model.
Sign Construction Based on Heightened Tactile Perception by Persons with Congenital Deafblindness
Authors: Forsgren Goran A.G.C. , Daelman Marlene , Hart Paul 
Published: October 2019

Low readability is a main concern regarding communication with persons with congenital deafblindness (Nafstad & Rødbroe, 2015). This is because most of the expressions come from the bodily-tactile modality and are often based on tactile iconicity. It is difficult for a seeing and hearing partner to understand these expressions from the perspective of cultural language.
The goal of this qualitative study is to show the emergence of sign constructions based on heightened tactile perception (Borchgrevink, 2002; Nicholas, 2004). Two videos, each showing one of two participants with congenital deafblindness, were subjected to qualitative micro-analysis. A key focus of this research concerns the combination of exploration and cognitive processing indicated by self-addressed expressions, and how this combination contributes to sign constructions. The linguistic quality of these sign constructions is further examined by detailing handshape, movement and location according to the work by Stokoe, 1960 and Bellugi & Klima, 2001. The results provide support for the proposition of a new sign category based on heightened tactile perception.
https://doi.org/10.21827/jdbsc.4.31373
Body with Body: Interacting with Children with Congenital Deafblindness in the Human Niche
Authors: Gregersen Anstein 
Published: October 2019

In deafblind studies it is commonly and usefully advised that partners interact close and face-to-face with children with congenital deafblindness. While recognizing face-to-face as an important mode of interaction this paper advances the simple idea that an equally important form of togetherness is body-with-body. Body-with-body interactions are here understood as interactions where two bodies are aligned with each other: the paradigmatic form is where the back of the child is aligned with the stomach and chest of his partner. I argue that this mode of togetherness can enable agency for a child with CDB through making as good as possible the conditions for perception and cognition. The body-with-body mode will make possible perception of the partners body in action; perception of some of the partners emotions; enable joint attention; enable skill acquisition and use of equipment, and finally enhance distal perception.
https://doi.org/10.21827/jdbsc.4.31374
Psychosocial Factors Affecting Artificial Intelligence Adoption in Health Care in China: Cross-Sectional Study
Authors: Ye Tiantian , Xue Jiaolong , He Mingguang , Gu Jing , Lin Haotian , Xu Bin , Cheng Yu 
Published: October 2019

Background
Poor quality primary health care is a major issue in China, particularly in blindness prevention. Artificial intelligence (AI) could provide early screening and accurate auxiliary diagnosis to improve primary care services and reduce unnecessary referrals, but the application of AI in medical settings is still an emerging field.

Objective
This study aimed to investigate the general public’s acceptance of ophthalmic AI devices, with reference to those already used in China, and the interrelated influencing factors that shape people’s intention to use these devices.

Methods
We proposed a model of ophthalmic AI acceptance based on technology acceptance theories and variables from other health care–related studies. The model was verified via a 32-item questionnaire with 7-point Likert scales completed by 474 respondents (nationally random sampled). Structural equation modeling was used to evaluate item and construct reliability and validity via a confirmatory factor analysis, and the model’s path effects, significance, goodness of fit, and mediation and moderation effects were analyzed.

Results
Standardized factor loadings of items were between 0.583 and 0.876. Composite reliability of 9 constructs ranged from 0.673 to 0.841. The discriminant validity of all constructs met the Fornell and Larcker criteria. Model fit indicators such as standardized root mean square residual (0.057), comparative fit index (0.915), and root mean squared error of approximation (0.049) demonstrated good fit. Intention to use (R2=0.515) is significantly affected by subjective norms (beta=.408; P<.001), perceived usefulness (beta=.336; P=.03), and resistance bias (beta=–.237; P=.02). Subjective norms and perceived behavior control had an indirect impact on intention to use through perceived usefulness and perceived ease of use. Eye health consciousness had an indirect positive effect on intention to use through perceived usefulness. Trust had a significant moderation effect (beta=–.095; P=.049) on the effect path of perceived usefulness to intention to use.

Conclusions
The item, construct, and model indicators indicate reliable interpretation power and help explain the levels of public acceptance of ophthalmic AI devices in China. The influence of subjective norms can be linked to Confucian culture, collectivism, authoritarianism, and conformity mentality in China. Overall, the use of AI in diagnostics and clinical laboratory analysis is underdeveloped, and the Chinese public are generally mistrustful of medical staff and the Chinese medical system. Stakeholders such as doctors and AI suppliers should therefore avoid making misleading or over-exaggerated claims in the promotion of AI health care products.
A Donor Utilization Index to Assess the Utilization and Discard of Deceased Donor Kidneys Perceived as High Risk
Authors: Brennan Corey , Husain Syed Ali , King Kristen L. , Tsapepas Demetra , Ratner Lloyd E. , Jin Zhezhen , Schold Jesse D. , Mohan Sumit 
Published: October 2019

Background and objectives
An increasing number of patients on the waitlist for a kidney transplant indicates a need to effectively utilize as many deceased donor kidneys as possible while ensuring acceptable outcomes. Assessing regional and center-level organ utilization with regards to discard can reveal regional variation in suboptimal deceased donor kidney acceptance patterns stemming from perceptions of risk.

Design, setting, participants, & measurements
We created a weighted donor utilization index from a logistic regression model using high-risk donor characteristics and discard rates from 113,640 deceased donor kidneys procured for transplant from 2010 to 2016, and used it to examine deceased donor kidney utilization in 182 adult transplant centers with >15 annual deceased donor kidney transplants. Linear regression and correlation were used to analyze differences in donor utilization indexes.

Results
The donor utilization index was found to significantly vary by Organ Procurement and Transplantation Network region (P<0.001), revealing geographic trends in kidney utilization. When investigating reasons for this disparity, there was no significant correlation between center volume and donor utilization index, but the percentage of deceased donor kidneys imported from other regions was significantly associated with donor utilization for all centers (rho=0.39; P<0.001). This correlation was found to be particularly strong for region 4 (rho=0.83; P=0.001) and region 9 (rho=0.82; P=0.001). Additionally, 25th percentile time to transplant was weakly associated with the donor utilization index (R
2=0.15; P=0.03).

Conclusions
There is marked center-level variation in the use of deceased donor kidneys with less desirable characteristics both within and between regions. Broader utilization was significantly associated with shorter time to transplantation.
THE ANALYSIS OF TRUST AS AN ELEMENT OF SUPPORT TO DEMOCRATIC PROCESSES
Authors: Đorić Žarko 
Published: October 2019

Declining trust is one of the central problems in modem politics. Trust declines in collective action arrangements. Trust is one of the "big questions," and "one of the normal obligations of political life." Embedded within it are fundamental issues of politics and democratic theory. In this article, I want to discuss which different conceptions of trust (and relations to democracy). The paper proceeds as follows. In the first part, the conceptual and theoretical definition of trust is given. In the second part it points to one of the basic division of trust which is present in the literature. Finally, in the third part, the relationship between trust and democracy is pointed out and appropriate argumentation is offered.
Effects of Magnetic Fields and Metal Ions (Cu, Pb, Al and Fe) on Growth of Anoxygenic Photosynthetic Bacteria (APB)
Authors: Sumardi  , Farisi Rochmah Agustrina Salman , Yunita  
Published: October 2019

Bakteri Fotosintetik Anoksigenik (BFA) memiliki sifat yang menguntungkan diantaranya sebagai kandidat probiotik, biofertilizer, agen bioremediasi dan mampu menurunkan konsetrasi H2S di perairan. Namun demikian BFA pun memiliki kelemahan yaitu pertumbuhannya lambat. Interaksi ion logam dan paparan medan magnet diketahui dapat meningkatkan aktivitas enzim dan meningkatkan laju pertumbuhan. Penelitian ini bertujuan untuk mengetahui pengaruh ion logam dan paparan medan magnet terhadap pertumbuhan BFA. Isolat BFA AM hasil isolasi dari akar mangrove diuji pengaruhnya terhadap ion logam dalam media sea water complete (SWC). Ion logam yang diujikan adalah Cu, Pb, Al dan Fe dengan konsentrasi yang berbeda. Ion logam dipapar medan magnet 0,2 mT selama 10 menit sebelum ditambahkan ke media. Hasil penghitungan sel menunjukkan bahwa ion logam baik yang dipapar medan magnet dan tanpa dipapar medan magnet tidak berpengaruh terhadap pertumbuhan isolat BFA AM, namun ion logam dalam media SWC mempengaruhi pola spektra isolat BFA AM.
How Often Do Managers Withhold Information?
Authors: Bertomeu Jeremy , Ma Paul , Marinovic Iván 
Published: October 2019

ABSTRACT
We estimate a dynamic model of voluntary disclosure, using annual management forecasts of earnings, that features a manager with price motives and an uncertain, but persistent, information endowment. Our estimates imply that: (1) managers face disclosure frictions 35 percent of the time; (2) conditional on being informed, managers withhold information 17 percent of the time; and (3) conditional on being silent, managers possess information 24 percent of the time. Managers' strategic withholding motives increase investors' uncertainty about earnings by 3 percent. We find that managers' price motives reduce strategic withholding by one-third in response to investors' increased skepticism in the event of non-disclosure.
JEL Classifications: D82; D83; G17.
R&D and the Rising Foreign Profitability of U.S. Multinational Corporations
Authors: De Simone Lisa , Huang Jingjing (Jing) , Krull Linda K. 
Published: October 2019

ABSTRACT
We investigate how R&D contributes to rising foreign profitability in U.S. multinational corporations through wage and tax incentives. Our results suggest that wage savings increase foreign profit margins derived from foreign R&D, while tax incentives increase foreign profit margins derived from domestic R&D. By exploring their relative importance, we find that wage savings are more important than tax incentives in explaining foreign profit margins when the wage discount substantially exceeds tax incentives, and vice versa. Cross-sectional tests show that firms respond more to foreign R&D wage savings when they have access to local human talent, but less as the cost of conducting foreign R&D increases. Firms respond less to tax incentives to shift income derived from domestic R&D as transfer pricing risk increases. Our evidence sheds light on the importance of R&D-related income shifting that potentially separates the location of economic activity from the location of income.
JEL Classifications: H25; H26.
MENGATASI PERMASALAHAN DAN PENINGKATAN PRESTASI BELAJAR IPA MELALUI KONSELING EKLEKTIF DENGAN PERILAKU ATTENDING PADA SISWA VIII B2 SEMESTER GANJIL TAHUN PELAJARAN 2018/2019 SMP NEGERI 6 SINGARAJA
Authors: Sukri Made 
Published: October 2019

Tujuan penelitian tindakan bimbingan konseling ini adalah (1) untuk mendiskripsikan peranan konseling dengan teknik Konseling Eklektif dengan Perilaku Attending dapat mengatasi permasalahan belajar siswa dalam mata pelajaran IPA, dan (2) untuk mendiskripsikanperanan konseling dengan teknik Konseling Eklektif dengan Perilaku Attending dapat meningkatkan prestasi belajar siswa dalam mata pelajaran IPA. Subyek penelitian tindakan bimbingan konseling ini adalah siswa kelas VIII B2 SMP Negeri 6 Singaraja Semester Ganjil Tahun Pelajaran 2018/2019. Obyek penelitian ini adalah masalah belajar IPA yang dihadapi siswa dan prestasi belajar IPA. Pemecahan masalah dalam penelitian tindakan bimbingan konseling (PTBK) ini menggunakan dua siklus yaitu siklus 1 dan siklus 2. Teknik pengumpulan data: masalah belajar IPA dengan kuisioner, prestasi belajar IPA dengan tes belajar IPA. Hasil penelitian menunjukkan (1) melaluiteknik Konseling Eklektif dengan Perilaku Attending dapat mengatasi permasalahan belajar siswa dalam mata pelajaran IPA; (2) melaluiteknik Konseling Eklektif dengan Perilaku Attending dapat meningkatkan prestasi/hasil belajar siswa dalam mata pelajaran IPA.
PERENCANAAN MESIN GILING RAMUAN JAMU DENGAN MENGGUNAKAN PENGGERAK DINAMO LISTRIK GUNA MENINGKATKAN HASIL PRODUKSI ( PLANNING OF MILLING MACHINE OF HERB INGREDIENT BY USING DYNAMO ELECTRICS ACTIVATOR UTILIZE TO IMPROVE PRODUCTION )
Authors: Suprihatin Endang 
Published: October 2019

Home industry property of Ms. Sarino in Countryside Karangrejo Sub-Province Banyuwangi in making of “jamu gendong” (Herb). In course of making herb still use the way of traditional that is by 100% still exploit manpower to producing it, so that production capacities had still lower. This Fact very regrettably because consumer request or market of traditional herb high enough.
In this research writer make milling machine of herb appliance moved by motor dynamo to replace pounding process which during the time eat time almost 4 hour in one day and very is extorting of energy. In making of the appliance exploit modified manual flesh milling machine with electrics dynamo activator. Research hypothesis told is exploiting milling machine of herb moved by motor dynamo can improve prosperity and advantage all producer of traditional herb.
Data analysis cover time calculation of herb and comparison of result before and after usage of milling machine. From result of data analysis and calculation obtained that appliance performance weared to reach 9 kg/day (in this time only 5 kg/day) and also earn is easily mastered and operated by traditional herb maker. Acceptable and lower Clunk arising out by society and also don’t cause aroma which isn’t delicate.
Result of research conclude that with usage of herb crusher machine assessed competent enough be achieved and can improve obtained profit, from previous equal Rp 20.802,- becoming Rp 43.792,- per day or go up equal to Rp 22.990,- (111 %).
MEMPERKIRAKAN KEDALAM RETAK PADA BETON MENGGUNAKAN GELOMBANG ULTRASONIK
Authors: Linggasari Dewi 
Published: October 2019

Tulisan ini mendiskusikan penggunaan gelombang ultrasonik untuk memperkirakan kedalaman retak terbuka. Teknik yang digunakan sangat berguna dalam pekerjaan di lapangan. Metode pengukuran menggunakan dua metode acuan yaitu standard BS 1881 bagian 203 sebagai metode 1 dan manual buku pada alat PUNDIT CNS Electronics sebagai metode ke 2, dengan gambaran persamaan matematika untuk menentukan kedalaman retak terbuka. Gelombang ultrasonik bekerja didasarkan pada pengukuran waktu tempuh gelombang ultrasonik yang menjalar dalam struktur beton. Gelombang ultrasonik disalurkan dari pengirim yang ditempatkan dipermukaan beton melalui material beton menuju penerima dan waktu tempuh gelombang tersebut diukur oleh Read-Out unit dalam mikro detik. Sejumlah balok uji disiapkan dengan penandaan arah keretakan untuk pengukuran. Hasil pengujian menunjukkan kedua metode yang digunakan untuk mengukur kedalaman keretakan memiliki kesesuain hasil antar satu terhadap yang lainnya. This paper discusses the use of ultrasonic waves to estimate the depth of open cracks. The technique used is very useful in work in the field. The measurement method uses two reference methods namely standard BS 1881 section 203 as method 1 and the book manual on the PUNDIT CNS Electronics tool as the second method, with an overview of mathematical equations to determine the depth of open cracks. Ultrasonic waves work based on measurements of the travel time of ultrasonic waves that propagate in concrete structures. Ultrasonic waves are transmitted from the sender placed on the concrete surface through concrete material to the receiver and the wave travel time is measured by the Read-Out unit in micro seconds. A number of test beams were prepared by marking the direction of the crack for measurement. The test results show that the two methods used to measure the depth of the crack have the suitability of the results between one another.
Pedagojik Sözlükbilimi Çalışmalarına Katkı: Yabancılar İçin Başlangıç Düzeyi Türkçe Sözlük (A1) (Contribution to the Studies of Pedagogical Lexicography: Beginning Level Turkish Dictionary for Foreigners (A1))
Authors: Yılmaz Engin 
Published: October 2019

Öğrenici profiline uygun öğretim araç-gereçlerinin yeterli düzeyde geliştirilememesi, Türkçenin yabancı dil olarak öğretiminde önemli bir sorun alanıdır. Nitekim, dil gelişimi için önemli olan otantik materyallerin ve işbirlikçi sistemlerin yeterli düzeyde olmayışı Türkçenin yabancı dil olarak öğretimi önünde “lojistik bariyer”ler olarak durmaktadır. Öğrenici düzeyine uygun olarak geliştirilemeyen materyallerin başında ise öğrenici sözlüğü gelmektedir. Bu konuda, artan çalışma ve araştırmalara rağmen Türkiye’de henüz model teşkil edebilecek bir eser ya da kaynak ortaya konulamamıştır. Tarafımızdan hazırlanan ve Pegem Akademi Yayınları arasında çıkan Yabancılar İçi Başlangıç Düzeyi Türkçe Sözlük (A1)adlı eser, öğrenici sözlüğü alanında öncü bir çalışma olarak değerlendirilebilir. Araştırma ile, Türkiye’de yeterince geliştirilememiş olan pedagojik sözlükbilimi (pedagogical lexicography) alanına kuramsal ve uygulamalı açıdan katkı sağlanması amaçlanmıştır. Çalışma, betimsel bir araştırma niteliğindedir.
Kâmûs-i Türkî’de Yer Alan Deyimler, Şemsettin Sami’nin Deyim Dünyasını Ne Ölçüde Kapsar? (To What Extent the Idioms in Kamus-i Turki Contain Şemseddin Sâmi’s Vocabulary of Idioms?)
Authors: Kutrolli Andija 
Published: October 2019

Deyimler söz
varlığında dilin yaratıcılık ve
kendine özgü kavramsallaştırma özelliklerini ortaya koyan, toplumun tarihini,
kültürel özelliklerini, değer yargılarını, bakış açılarını yansıtan önemli unsurlarıdır.
Tarihî metinler üzerine yapılan incelemeler Türklerin en eski dönemlerden
itibaren yaygın olarak deyim kullandığını göstermektedir. Şemseddin Sami, Kâmûs-i
Türkî’de 3017 deyime yer vermiştir. Çağdaş Türkiye Türkçesi sözlüklerinde ise
bu sayı 8500 civarındadır. Bu çalışmada Şemseddin Sami’nin deyim dünyasının araştırılması
amacıyla örneklem olarak “Gâve”
adlı piyesi ele alınmıştır. Çalışmada söz konusu piyeste yer alan deyimler belirlenerek
kullanım sıklığına göre değerlendirilmiş ve çağdaş Türkiye Türkçesi söz varlığı
ile karşılaştırılmıştır. Şemseddin Sami’nin Kâmûs-ı Türkî’de yer verdiği ve
günümüz Türkiye Türkçesinde de yer alan yalnız 49 deyimin piyeste geçtiği
tespit edilmiştir.