bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development of a neonatal adverse event severity scale through a Delphi consensus approach
Authors: Salaets Thomas , Turner Mark A , Short Mary , Ward Robert M , Hokuto Isamu , Ariagno Ronald L , Klein Agnes , Beauman Sandra , Wade Kelly , Thomson Merran , Roberts Eve , Harrison Judy , Quinn Theresa , Baer Gerri , Davis Jonathan , Allegaert Karel 
Published: September 2019

BackgroundAssessment of the seriousness, expectedness and causality are necessary for any adverse event (AE) in a clinical trial. In addition, assessing AE severity helps determine the importance of the AE in the clinical setting. Standardisation of AE severity criteria could make safety information more reliable and comparable across trials. Although standardised AE severity scales have been developed in other research fields, they are not suitable for use in neonates. The development of an AE severity scale to facilitate the conduct and interpretation of neonatal clinical trials is therefore urgently needed.MethodsA stepwise consensus process was undertaken within the International Neonatal Consortium (INC) with input from all relevant stakeholders. The consensus process included several rounds of surveys (based on a Delphi approach), face-to-face meetings and a pilot validation.ResultsNeonatal AE severity was classified by five grades (mild, moderate, severe, life threatening or death). AE severity in neonates was defined by the effect of the AE on age appropriate behaviour, basal physiological functions and care changes in response to the AE. Pilot validation of the generic criteria revealed κ=0.23 and guided further refinement. This generic scale was applied to 35 typical and common neonatal AEs resulting in the INC neonatal AE severity scale (NAESS) V.1.0, which is now publicly available.DiscussionThe INC NAESS is an ongoing effort that will be continuously updated. Future perspectives include further validation and the development of a training module for users.
School-based lifestyle education involving parents for reducing subjective psychosomatic symptoms in Japanese adolescents: study protocol for a cluster randomised controlled trial
Authors: Watanabe Junko , Watanabe Mariko , Yamaoka Kazue , Adachi Misa , Nemoto Asuka , Tango Toshiro 
Published: September 2019

IntroductionSevere subjective psychosomatic symptoms (SPS) in adolescents are a major public health concern, and lifestyle modification interventions for reducing SPS are important topics. Recently, we developed a school-based lifestyle education involving parents for reducing SPS of adolescents (SPRAT), an improved version of the programme from our previous study Programme for adolescent of lifestyle education in Kumamoto (PADOK). This study aimed to evaluate the effectiveness of SPRAT in reducing SPS among adolescents.Methods and analysisThis is a 6-month, cluster randomised clinical trial with two intervention arms (SPRAT vs usual school education). The study population will be composed of middle school students (aged 12–14 years) with their parents/guardians in Japan. SPRAT is expected to be a more powerful programme than PADOK as it reinforces the role of parent participation. The primary endpoint will be the change from baseline SPS scores to those obtained after 6 months. Between-group differences will be analysed following the intention-to-treat principle. Crude and multivariate adjusted effects will be examined using a general linear mixed-effects model for continuous variables and a logistic regression model for dichotomous variables. The sample size required was determined based on the information needed to detect a difference in the primary outcome with a significance level of 5% and power of 80% under the assumptions of 40 students per cluster (assuming the same sample size for each cluster), an effect size of 0.3 and an intraclass correlation coefficient of 0.02. In total, participation by 28 schools (14 schools in each arm) (students: n=1120) will be needed.Ethics and disseminationThis study was approved by the Medical Ethical Committee of Minami Kyushu University in 2017 (number 137). The findings will be disseminated widely through peer-reviewed publications and conference presentations.Trial registration numberUMIN000026715; Pre-results.
Occupational exposure to wood dust and risk of lung cancer: the ICARE study
Authors: Matrat Mireille , Radoï Loredana , Févotte Joëlle , Guida Florence , Cénée Sylvie , Cyr Diane , Sanchez Marie , Menvielle Gwenn , Schmaus Annie , Marrer Emilie , Luce Danièle , Stücker Isabelle 
Published: September 2019

ObjectivesIn a previous analysis of data from a French population-based case–control study (the Investigation of occupational and environmental CAuses of REspiratory cancers (ICARE) study), ‘having ever worked’ in wood-related occupations was associated with excess lung cancer risk after adjusting for smoking but not for occupational factors. The present study aimed to investigate the relationship between lung cancer risk and wood dust exposure after adjusting for occupational exposures.MethodsData were obtained from 2276 cases and 2780 controls on smoking habits and lifelong occupational history, using a standardised questionnaire with a job-specific questionnaire for wood dust exposure. Logistic regression models were used to calculate ORs and 95% CIs adjusted for age, area of residence, tobacco smoking, the number of job periods and exposure to silica, asbestos and diesel motor exhaust (DME).ResultsNo significant association was found between lung cancer and wood dust exposure after adjustment for smoking, asbestos, silica and DME exposures. The risk of lung cancer was slightly increased among those who were exposed to wood dust more than 10 years, and had over 40 years since the first exposure.ConclusionOur findings do not provide a strong support to the hypothesis that wood dust exposure is a risk factor for lung cancer. This study showed the importance of taking into account smoking and occupational coexposures in studies on lung cancer and wood dust exposure. Further studies evaluating the level and frequency of exposure during various tasks in woodwork are needed.
Preliminary findings and outcomes associated with the use of a continuous spinal protocol for labor pain relief following accidental dural puncture
Authors: Izquierdo Marcos , Wang Xiao-Feng , Wagner III Karl , Prada Cristian , Torres Augusto , Bolden Norman 
Published: September 2019

Background
Various interventions have shown promise in reducing complications following accidental dural puncture. However, these have yet to be studied as a single, comprehensive protocol. The aim of this study is to compare outcomes associated with the use of a continuous spinal protocol for labor pain relief versus resiting the epidural catheter following accidental dural puncture.

Methods
We reviewed the charts of patients managed via our continuous spinal protocol and compared this group with patients for whom the epidural was resited following accidental dural puncture during the 5-year period prior to implementing our protocol. We assessed incidence of postdural puncture headache, epidural blood patch, frequency of catheter replacement, use of pressors, verbal pain scores at 0, 1, 2, 3, 4 hours following catheter placement, infection rates (meningitis/epidural abscess) and mode of delivery.

Results
There were 129 women in the continuous spinal protocol group and 52 in the resited epidural group. The incidence of postdural puncture headache was lower in the continuous spinal group versus the resited epidural group (21.7% vs 67.3%, p<0.001), and the incidence of epidural blood patch was lower in the continuous spinal group versus the resited epidural group (12.4% vs 50.0%, p<0.001). Verbal pain scores were consistently lower in the continuous spinal group compared with the resited epidural group at all time intervals studied.

Conclusion
Patients managed via this continuous spinal protocol had significantly lower incidence of postdural puncture headache and epidural blood patch with more effective labor analgesia following accidental dural puncture.
Differences in price of flavoured and non-flavoured tobacco products sold in the USA, 2011–2016
Authors: Agaku Israel T , Odani Satomi , Armour Brian , Mahoney Margaret , Garrett Bridgette E , Loomis Brett R , Rogers Todd , Gammon Doris G , King Brian A 
Published: September 2019

BackgroundLimited data exist on whether there is differential pricing of flavoured and non-flavoured varieties of the same product type. We assessed price of tobacco products by flavour type.MethodsRetail scanner data from Nielsen were obtained for October 2011 to January 2016. Universal product codes were used to classify tobacco product (cigarettes, roll-your-own cigarettes (RYO), little cigars and moist snuff) flavours as: menthol, flavoured or non-flavoured. Prices were standardised to a cigarette pack (20 cigarette sticks) or cigarette pack equivalent (CPE). Average prices during 2015 were calculated overall and by flavour designation. Joinpoint regression and average monthly percentage change were used to assess trends.ResultsDuring October 2011 to January 2016, price trends increased for menthol (the only flavour allowed in cigarettes) and non-flavoured cigarettes; decreased for menthol, flavoured and non-flavoured RYO; increased for flavoured little cigars, but decreased for non-flavoured and menthol little cigars; and increased for menthol and non-flavoured moist snuff, but decreased for flavoured moist snuff. In 2015, average national prices were US$5.52 and US$5.47 for menthol and non-flavoured cigarettes; US$1.89, US$2.51 and US$4.77 for menthol, non-flavoured and flavoured little cigars; US$1.49, US$1.64 and US$1.78 per CPE for menthol, non-flavoured and flavoured moist snuff; and US$0.93, US$1.03 and $1.64 per CPE flavoured, menthol and non-flavoured RYO, respectively.ConclusionTrends in the price of tobacco products varied across products and flavour types. Menthol little cigars, moist snuff and RYO were less expensive than non-flavoured varieties. Efforts to make flavoured tobacco products less accessible and less affordable could help reduce tobacco product use.
Prediction of stress responses in goats: comparison of artificial neural network and multiple regression models
Authors: Kannan G. , Gosukonda R. , Mahapatra A.K. 
Published: September 2019

This study was conducted to determine if artificial neural networks (ANN) can be used to more accurately predict physiological stress responses in goats compared with statistical regression. Prediction models were developed for plasma cortisol and glucose concentrations, creatine kinase (CK) activity, neutrophil (N) and lymphocyte (L) counts, and N:L ratio as a function of time (0, 1, 2, 3, and 4 h; n = 16 goats per time) after a 2.5 h transportation (input 1) and stocking density (25 vs. 50 goats; input 2). However, input 2 was not included in the final models because density did not have a significant effect. The NeuralWorks Predict® software and SAS were used to develop ANN and regression models, respectively. Backpropagation (BP) and Kalman filter (KF) learning rules were used to develop nonparametric models. Correlations between predicted and observed values were better with ANN-BP (R values = 0.87, 0.67, 0.56, 0.27, 0.42, and 0.53) and ANN-KF (R values = 0.84, 0.67, 0.58, 0.27, 0.42, and 0.50) models for cortisol, glucose, CK, N, L, and N:L ratio, respectively, than with regression models (R values =0.85, 0.52, 0.27, 0.13, 0.31, and 0.12). The results showed that the ANN models can predict responses more robustly compared with statistical regression.
Particle motion around generic black holes coupled to non-linear electrodynamics
Authors: Vrba Jaroslav , Abdujabbarov Ahmadjon , Tursunov Arman , Ahmedov Bobomurat , Stuchlík Zdeněk 
Published: September 2019

Abstract
We study spherically symmetric magnetically charged generic black hole solutions of general relativity coupled to non-linear electrodynamics (NED). For characteristic values of the generic spacetime parameters we give the position of horizons in dependence on the charge parameter, demonstrating separation of the black hole and no-horizon solutions, and possibility of existence of solutions containing three horizons. We show that null, weak and strong energy conditions are violated when the outer horizon is approaching the center. We study effective potentials for photons and massive test particles and location of circular photon orbits (CPO) and innermost stable circular orbit (ISCO). We show that the unstable photon orbit can become stable, leading to the possibility of photon capture which affects on silhouette of the central object. The position of ISCO approaches the horizon with increasing charge parameter q and the energy at ISCO decreases with increasing charge parameter. We investigate this phenomenon and summarize for a variety of the generic spacetime parameters the upper estimate on the spin parameter of the Kerr black which can be mimicked by the generic charged black hole solutions.
Serum CD95L Level Correlates with Tumor Immune Infiltration and Is a Positive Prognostic Marker for Advanced High-Grade Serous Ovarian Cancer
Authors: De La Motte Rouge Thibault , Corné Julien , Cauchois Aurélie , Le Boulch Marie , Poupon Clotilde , Henno Sébastien , Rioux-Leclercq Nathalie , Le Pabic Estelle , Laviolle Bruno , Catros Véronique , Levêque Jean , Fautrel Alain , Le Gallo Matthieu , Legembre Patrick , Lavoué Vincent 
Published: September 2019

Abstract

Soluble CD95L (s-CD95L) is a chemoattractant for certain lymphocyte subpopulations. We examined whether this ligand is a prognostic marker for high-grade serous ovarian cancer (HGSOC) and whether it is associated with accumulation of immune cells in the tumor. Serum s-CD95L levels in 51 patients with advanced ovarian cancer were tested by ELISA. IHC staining of CD3, CD4, CD8, CD20, CD163, CD31, FoxP3, CCR6, IL-17, Granzyme B, PD-L1, and membrane CD95L was used to assess tumor-infiltrating immune cells. Although the intensity of CD3, CD8, CD4, CD20, and CD163 in tumor tissues remained constant regardless of membrane CD95L expression, tumors in patients with HGSOC with s-CD95L levels ≥516 pg/mL showed increased infiltration by CD3+ T cells (P = 0.001), comprising both cytotoxic CD8+ (P = 0.01) and CD4+ (P = 0.0062) cells including FoxP3+ regulatory T cells (P = 0.0044). Also, the number of tumor-infiltrating CD20+ B cells (P = 0.0094) increased in these patients. Multivariate analyses revealed that low s-CD95L concentrations [&lt;516 pg/mL, HR, 3.54; 95% confidence interval (CI), 1.13–11.11), and &lt;1,200 activated CD8+ (Granzyme B+) cells (HR, 2.63; 95% CI, 1.16–5.95) were independent poor prognostic factors for recurrence, whereas &gt;6,000 CD3+ cells (HR, 0.34; 95% CI, 0.15–0.79) was a good prognostic factor. Thus, low levels of s-CD95L (&lt;516 pg/mL) are correlated with lower numbers of tumor-infiltrating lymphocytes (CD3+ and CD8+, and also CD4 and FoxP3 T cells) in advanced HGSOC and are a poor prognostic marker.

Implications:
Serum s-CD95L is correlated with a number of tumor-infiltrating immune cells in HGSOC and could be used as a noninvasive marker of tumor immune infiltration to select patients referred for immunotherapy trials that evaluate checkpoint inhibitor treatment.
Identification of Emetine as a Therapeutic Agent for Pulmonary Arterial Hypertension
Authors: Siddique Mohammad Abdul Hai , Satoh Kimio , Kurosawa Ryo , Kikuchi Nobuhiro , Elias-Al-Mamun Md. , Omura Junichi , Satoh Taijyu , Nogi Masamichi , Sunamura Shinichiro , Miyata Satoshi , Ueda Hirofumi , Tokuyama Hidetoshi , Shimokawa Hiroaki 
Published: September 2019

Objective:
Excessive proliferation and apoptosis resistance are special characteristics of pulmonary artery smooth muscle cells (PASMCs) in pulmonary arterial hypertension (PAH). However, the drugs in clinical use for PAH target vascular dilatation, which do not exert adequate effects in patients with advanced PAH. Here, we report a novel therapeutic effect of emetine, a principal alkaloid extracted from the root of ipecac clinically used as an emetic and antiprotozoal drug.

Approach and Results:
We performed stepwise screenings for 5562 compounds from original library. First, we performed high-throughput screening with PASMCs from patients with PAH (PAH-PASMCs) and found 80 compounds that effectively inhibited proliferation. Second, we performed the repeatability and counter assay. Finally, we performed a concentration-dependent assay and found that emetine inhibits PAH-PASMC proliferation. Interestingly, emetine significantly reduced protein levels of HIFs (hypoxia-inducible factors; HIF-1α and HIF-2α) and downstream PDK1 (pyruvate dehydrogenase kinase 1). Moreover, emetine significantly reduced the protein levels of RhoA (Ras homolog gene family, member A), Rho-kinases (ROCK1 and ROCK2 [rho-associated coiled-coil containing protein kinases 1 and 2]), and their downstream CyPA (cyclophilin A), and Bsg (basigin) in PAH-PASMCs. Consistently, emetine treatment significantly reduced the secretion of cytokines/chemokines and growth factors from PAH-PASMCs. Interestingly, emetine reduced protein levels of BRD4 (bromodomain-containing protein 4) and downstream survivin, both of which are involved in many cellular functions, such as cell cycle, apoptosis, and inflammation. Finally, emetine treatment ameliorated pulmonary hypertension in 2 experimental rat models, accompanied by reduced inflammatory changes in the lungs and recovered right ventricular functions.

Conclusions:
Emetine is an old but novel drug for PAH that reduces excessive proliferation of PAH-PASMCs and improves right ventricular functions.
Selecting and Removing Arbitrators in International Investment Arbitration
Authors: Giorgetti Chiara 
Published: September 2019

Abstract
This book explores and assesses two essential features in investor state dispute resolution (ISDS): the selection and the removal of arbitrators. Both topics have received increasing scrutiny and criticism, that have in turn generated calls for reforms. In its first part, this book explains the selection of arbitrators procedurally and comparatively under the most-often used arbitration rules. It then reviews critically the necessary and desirable qualities for arbitrators’ selection and appointment, and addresses some important and related policy issues, such diversity and repeat appointments. Finally, it discusses the recent calls to review the methodologies used to appoint arbitrators, and specifically the proposal by the European Commission to create a permanent tribunal to resolve international investment disputes, the UNCITRAL Working Group III Reform Process and the rules amendment proposal undertaken by the Secretariat of the International Center for Settlement of Investment Disputes (ICSID Secretariat). In its second part, the book addresses the companion and similarly important issue of challenging and removing arbitrators. It does so by reviewing first the provisions that are appplied under a variety of arbitration rules to remove arbitrators who fail to possess the necessary qualities to sit in arbitral proceedings. It then evaluates the reasons for challenge and discusses some important cases that addressed challenges. The book assesses appointments and removals in a multifaceted and comprehensive way, and includes a critical assessment of the reasons and calls for reform of the ISDS system.
Scale Analysis of Moist Thermodynamics in a Simple Model and the Relationship between Moisture Modes and Gravity Waves
Authors: Adames Ángel F. , Kim Daehyun , Clark Spencer K. , Ming Yi , Inoue Kuniaki 
Published: September 2019

AbstractObservations and theory of convectively coupled equatorial waves suggest that they can be categorized into two distinct groups. Moisture modes are waves whose thermodynamics are governed by moisture fluctuations. The thermodynamics of the gravity wave group, on the other hand, are rooted in buoyancy (temperature) fluctuations. On the basis of scale analysis, it is found that a simple nondimensional parameter—akin to the Rossby number—can explain the processes that lead to the existence of these two groups. This parameter, defined as Nmode, indicates that moisture modes arise when anomalous convection lasts sufficiently long so that dry gravity waves eliminate the temperature anomalies in the convective region, satisfying weak temperature gradient (WTG) balance. This process causes moisture anomalies to dominate the distribution of moist enthalpy (or moist static energy), and hence the evolution of the wave. Conversely, convectively coupled gravity waves arise when anomalous convection eliminates the moisture anomalies more rapidly than dry gravity waves can adjust the troposphere toward WTG balance, causing temperature to govern the moist enthalpy distribution and evolution. Spectral analysis of reanalysis data indicates that slowly propagating waves (cp ~ 3 m s−1) are likely to be moisture modes while fast waves (cp ~ 30 m s−1) exhibit gravity wave behavior, with “mixed moisture–gravity” waves existing in between. While these findings are obtained from a highly idealized framework, it is hypothesized that they can be extended to understand simulations of convectively coupled waves in GCMs and the thermodynamics of more complex phenomena.
Climatology of Low-Level Jets and Their Impact on Rainfall over Southern China during the Early-Summer Rainy Season
Authors: Du Yu , Chen Guixing 
Published: September 2019

AbstractLow-level jets (LLJs) are a key factor regulating the early-summer rainfall over southern China. Their detailed activities and impact are examined using 21-yr ERA5 and TRMM rainfall data. The LLJs typically consist of boundary layer jets (BLJs) and synoptic-system-related LLJs (SLLJs). The BLJ is usually characterized by a southerly wind maximum at 950 hPa over the northern area of South China Sea, whereas the SLLJ features a southwesterly wind maximum at 850–700 hPa located more north on land. Meanwhile, the BLJ (SLLJ) has a maximum occurrence in April–June (May–July) and at late night (in the early morning), indicating the differences in seasonal and diurnal variations. The two types of LLJs are found to influence the rainfall distribution via terrain effects, synoptic disturbances, and moisture transport. During the BLJ events, rainfall is mainly confined to the south side of the Nanling and Wuyi Mountains and Yun-Gui Plateau (south region), whereas during the SLLJ events rainfall occurs both in the coastal region and to the north of the mountains (north region). The difference is caused by the southerly BLJ that induces strong orographic lifting on the windward side of the mountains, while the elevated SLLJ can pass over the mountains driving an additional upward motion more north. Active synoptic disturbances accompanied by SLLJs are also favorable for the rainfall in the north region. The moisture transportation by LLJs is another important factor regulating rainfall distribution. Rainfall in the south (north) region is mainly attributed to the net moisture flux in the boundary layer (more elevated layers) due to the BLJ (SLLJ).