bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of secondary care financial incentives on the quality of physical healthcare for people with psychosis: a longitudinal controlled study
Authors: Crawford Mike J. , Huddart Daniel , Craig Eleanor , Zalewska Krysia , Quirk Alan , Shiers David , Strathdee Geraldine , Cooper Stephen J. 
Published: July 2019

BackgroundConcerns have repeatedly been expressed about the quality of physical healthcare that people with psychosis receive.AimsTo examine whether the introduction of a financial incentive for secondary care services led to improvements in the quality of physical healthcare for people with psychosis.MethodLongitudinal data were collected over an 8-year period on the quality of physical healthcare that people with psychosis received from 56 trusts in England before and after the introduction of the financial incentive. Control data were also collected from six health boards in Wales where a financial incentive was not introduced. We calculated the proportion of patients whose clinical records indicated that they had been screened for seven key aspects of physical health and whether they were offered interventions for problems identified during screening.ResultsData from 17 947 people collected prior to (2011 and 2013) and following (2017) the introduction of the financial incentive in 2014 showed that the proportion of patients who received high-quality physical healthcare in England rose from 12.85% to 31.65% (difference 18.80, 95% CI 17.37–20.21). The proportion of patients who received high-quality physical healthcare in Wales during this period rose from 8.40% to 13.96% (difference 5.56, 95% CI 1.33–10.10).ConclusionsThe results of this study suggest that financial incentives for secondary care mental health services are associated with marked improvements in the quality of care that patients receive. Further research is needed to examine their impact on aspects of care that are not incentivised.
Chronic Light Cycle Disruption Alters Central Insulin and Leptin Signaling as well as Metabolic Markers in Male Mice
Authors: Skinner Nathan J , Rizwan Mohammed Z , Grattan David R , Tups Alexander 
Published: July 2019

Abstract
Recent evidence suggests that the circadian timing system plays a role in energy and glucose homeostasis, and disruptions to this system are a risk factor for the development of metabolic disorders. We exposed animals to a constantly shifting lighting environment comprised of a 6-hour advance, occurring every 6 days, to chronically disrupt their circadian timing system. This treatment caused a gradual increase in body weight of 12 ± 2% after 12 phase shifts, compared with a 6 ± 1% increase in mice under control lighting conditions. Additionally, after the fifth phase shift, light cycle–disrupted (CD) animals showed a reversal in their diurnal pattern of energy homeostasis and locomotor activity, followed by a subsequent loss of this rhythm. To investigate potential molecular mechanisms mediating these metabolic alterations, we assessed central leptin and insulin sensitivity. We discovered that CD mice had a decrease in central leptin signaling, as indicated by a reduction in the number of phosphorylated signal transducer and activator of transcription 3 immunoreactive cells in the arcuate nucleus of the hypothalamus. Furthermore, CD animals exhibited a marked increase in fasting blood glucose (269.4 ± 21.1 mg/dL) compared with controls (108.8 ± 21.3 mg/dL). This dramatic increase in fasting glucose levels was not associated with an increase in insulin levels, suggesting impairments in pancreatic insulin release. Peripheral hyperglycemia was accompanied by central alterations in insulin signaling at the level of phospho Akt and insulin receptor substrate 1, suggesting that light cycle disruption alters central insulin signaling. These results provide mechanistic insights into the association between light cycle disruption and metabolic disease.
The effects of crizotinib in a transgenic Drosophila model expressing the human TPM4-ALK fusion gene or TPM4
Authors: Kim Yoo Jin , Cho A-Ri , Sul Hee Jung , Kim Bohyun , Kim A-Young , Kim Hyeong Su , Seo Jong Bok , Koh Youngho , Zang Dae Young 
Published: July 2019

ABSTRACT
Anaplastic lymphoma kinase (ALK) fusion events lead to constitutive activation of the ALK kinase domain, thereby functioning as oncogenic drivers. These fusion proteins have been identified in numerous cancers. Crizotinib, a small molecule inhibitor of c-Met and ALK, is a Food and Drug Administration-approved drug with reported efficacy in the treatment of cancer. Tropomyosins (TPMs) are a family of actin filament-binding proteins. Altered TPM expression has been found in a variety of human tumors. Inhibitors of cancer-associated TPMs and actin-targeting compounds have been developed, but anti-actin agents have cardiac and respiratory muscle toxicities. In this study, we investigated the sensitivities of human TPM4 (hTPM4), human ALK (hALK), and their fusion gene (hTPM4-hALK) to crizotinib by measuring the lifespan of transgenic Drosophila. Flies overexpressing hTPM4-hALK, hTPM4 and hALK showed decreased lifespans compared with controls. Although crizotinib is an inhibitor of ALK, treatment with crizotinib significantly extended the lifespans of Drosophila expressing hTPM4 and hTPM4-hALK but had no effect on hALK-expressing flies. Autophosphorylation of Tyr1278 is necessary for full activation of the ALK domain. We confirmed that hTPM4-hALK was phosphorylated at Tyr1278 in a ligand-independent manner, and hTPM4-hALK-expressing flies treated with crizotinib showed a decreased level of Tyr1278 phosphorylation compared with untreated hTPM4-hALK-expressing flies, with a greater decrease induced by 1 µM compared with 200 nM crizotinib. Taken together, the results suggest that crizotinib is effective for treating ALK-driven cancer and might be a new therapeutic drug, without cardiac or respiratory muscle toxic effects, for TPM4-expressing cancers.
Single Crystal Growth of Two-Dimensional Cyano-Bridged Coordination Polymer of Co(H2O)2Ni(CN)4·4H2O Using Trisodium Citrate Dihydrate
Authors: Azhar Alowasheeir , Zakaria Mohamed Barakat , Kim Jeonghun , Na Jongbeom , Kaneti Yusuf Valentino , Fatehmulla Amanullah , Aldhafiri Abdullah M , Farooq W Aslam , Bando Yoshio , Yamauchi Yusuke , Lin Jianjian 
Published: July 2019

Abstract
Single crystal Co(H2O)2Ni(CN)4·4H2O has been successfully synthesized by a slow diffusion method using trisodium citrate dihydrate for controlling the nucleation rate and the crystal growth. The single crystal X-ray diffraction results show the obtained crystals with a two-dimensional orthorhombic unit cell, assembled from cationic Co ions and anionic [Ni(CN)4]2− units connected by bridging cyanide groups.
Clinical-radiomics nomograms for pre-operative differentiation of sacral chordoma and sacral giant cell tumor based on 3D computed tomography and multiparametric magnetic resonance imaging
Authors: Yin Ping , Mao Ning , Wang Sicong , Sun Chao , Hong Nan 
Published: July 2019

Objective:
To develop and validate clinical-radiomics nomograms based on three-dimensional CT and multiparametric MRI (mpMRI) for pre-operative differentiation of sacral chordoma (SC) and sacral giant cell tumor (SGCT).

Methods:
A total of 83 SC and 54 SGCT patients diagnosed through surgical pathology were retrospectively analyzed. We built six models based on CT, CT enhancement (CTE), T 1 weighted, T 2 weighted, diffusion-weighted imaging (DWI), and contrast-enhanced T 1 weighted features, two radiomics nomograms and two clinical-radiomics nomograms combined radiomics mixed features with clinical data. The area under the receiver operating characteristic curve (AUC) and accuracy (ACC) analysis were used to assess the performance of the models.

Results:
SC and SGCT presented significant differences in terms of age, sex, and tumor location (tage = 9.00, χ2 sex = 10.86, χ2 location = 26.20; p &lt; 0.01). For individual scan, the radiomics model based on diffusion-weighted imaging features yielded the highest AUC of 0.889 and ACC of 0.885, followed by CT (AUC = 0.857; ACC = 0.846) and CT enhancement (AUC = 0.833; ACC = 0.769). For the combined features, the radiomics model based on mixed CT features exhibited a better AUC of 0.942 and ACC of 0.880, whereas mixed MRI features achieved a lower performance than the individual scan. The clinical-radiomics nomogram based on combined CT features achieved the highest AUC of 0.948 and ACC of 0.920.

Conclusions:
The radiomics model based on CT and multiparametricMRI present a certain predictive value in distinguishing SC and SGCT, which can be used for auxiliary diagnosis before operation. The clinical-radiomics nomograms performed better than radiomics nomograms.

Advances in knowledge:
Clinical-radiomics nomograms based on CT and mpMRI features can be used for preoperative differentiation of SC and SGCT.
Impact of dual diagnosis in patients with schizophrenia and affective disorders during hospital treatment on the course of illness and outcomes of treatment – a preliminary report
Authors: Błachut Michał , Ścisło Piotr , Jarząb Magdalena , Zając Magdalena , Piegza Magdalena , Badura-Brzoza Karina , Gorczyca Piotr 
Published: July 2019

Cel pracyPorównanie przebiegu choroby i funkcjonowania, występowania chorób somatycznych pomiędzy pacjentami z podwójną diagnozą, uzależnionymi bez współistnienia choroby psychicznej i osób chorych na schizofrenię lub choroby afektywne. Zwrócenie uwagi na potrzeby i problemy osób z podwójną diagnozą i potrzebę dłuższych hospitalizacji tej grupy pacjentów.MetodaZbadano 108 osób w trakcie leczenia w zamkniętym oddziale psychiatrycznym, oceniono występowanie chorób somatycznych, urazów, wypisów na własne żądanie ze szpitali, podejmowanie prób samobójczych, zachowań agresywnych. Poprzez wykorzystanie własnych ankiet porównano dane socjodemograficzne oraz dane o dotychczasowym przebiegu choroby i leczenia pomiędzy pacjentami z podwójną diagnozą (n=30), z chorobą psychiczną (n=41) i uzależnieniem od substancji psychoaktywnych (n=37).WynikiW grupie PD chorzy częściej podejmowali próby samobójcze, w młodszym wieku rozpoczynali używanie substancji psychoaktywnych. W grupie PD istotnie więcej osób było przed zawarciem małżeństwa lub po rozwodzie. W grupach PD i chorych psychicznie (K) było istotnie więcej osób, którzy byli w ciągu życia hospitalizowani powyżej 180 dni. Nie wykazano istotnych statystycznie różnic między grupami porównując częstość występowania chorób somatycznych, urazów, wypadków, wypisów na żądanie ze szpitali, czy zachowań agresywnych.WnioskiZ powodu słabej współpracy, częstego przerywania leczenia, większego ryzyka samobójczego w grupie pacjentów z podwójną diagnozą, wymagają oni dłuższych hospitalizacji psychiatrycznych w celu ustabilizowania stanu psychicznego, regularnego leczenia farmakologicznego, zapewnienia wsparcia społecznego, motywacji i przygotowania do leczenia odwykowego. Konieczne jest podjęcie działań zmierzających do stworzenia standardów postępowania terapeutycznego oraz dostosowania finansowania do potrzeb tej grupy chorych leczonych w Polsce.
Electromyostimulation as an element supporting sports training
Authors: Kowza-Dzwonkowska Małgorzata 
Published: July 2019

Purpose: The aim of the publication is to present the possibilities associated with the use of skeletal muscle electrostimulation as an element supporting sports training. The advantage of this form of training is the performance of specific work by select muscle, especially in less experienced players who can’t isolate a particular muscle during exercise. The electric impulse causes synchronous activation of the muscle contraction in the standard and reproducible conditions, resulting in a much higher level of muscle activity over time.Design / methodology / approach: The effect of muscle electrostimulation on muscle tissue and physiological changes, on the improvement of motor features and the EMS equation for sports training was discussed.Findings: EMS improves the jumping ability (Maffiuletti, Cometti et al. 2000), the maximum muscle strength has also increased (Maffiuletti, Bramanti et al. 2009). Short-term stimulation of low-frequency muscles dramatically shortens the time of getting a contraction. After prolonged stimulation, this result is improved, but it is slower than in the initial phase (Heilmann and Pette 1979). A series of suitable treatments leads to the enlargement of the area of the muscle section, a significant increase in the maximum strength and increase in muscle activation (Gondin, Guette et al. 2005, Kästner, Braun et al. 2015). Recently, it has been shown that EMS regenerates skeletal muscle by reducing the oxidative status in satellite cells muscle hypertrophy and the formation of new myofibrils (Di Filippo, Mancinelli et al. 2017). EMS as a sports training is similar to 4-fold longer training with high intensity exercises (Kemmler, Teschler et al. 2016).Research and practical limitations / implications: Due to reports that EMS affects muscle regeneration, you can use this method as part of wellness during the journey, when other forms are not available or as a short-term training.Originality / value: In summary, a properly selected series of skeletal muscle electrostimulation may affect muscle strength, muscle mass, jumping, speed and endurance as well as changing the structure of muscle fibers.
KOMPARASI PRODUKSI DAN PENDAPATAN PETANI TEBU MITRA DAN NON MITRA PABRIK GULA RENDENG DI KABUPATEN KUDUS
Authors: Kumalasari Annisa Dyah , Budiraharjo Kustopo , Setiadi Agus 
Published: July 2019

Penelitian ini bertujuan untuk menganalisis komparasi pendapatan per bulan petani tebu mitra dan non mitra dengan Upah Minimum Kabupaten/Kota (UMK) Kudus, menganalisis komparasi produksi petani tebu mitra dan non mitra, menganalisis komparasi pendapatan petani tebu mitra dan non mitra PG Rendeng di Kabupaten Kudus. Penelitian ini dilaksanakan pada Januari hingga Maret 2018 di Kecamatan Jekulo, Gebog dan Dawe, Kabupaten Kudus. Metode penelitian yang digunakan pada penelitian ini ialah survai. Penentuan sampel menggunakan metode quota sampling dengan jumlah sampel 30 petani tebu mitra dan 30 petani tebu non mitra. Analisis data yang digunakan ialah analisis pendapatan, uji beda One Sample t Test, Mann Whitney, dan Independent Sample t Test. Hasil penelitian menunjukkan bahwa terdapat perbedaan pendapatan per bulan petani tebu mitra dan non mitra dengan UMK Kudus. Tidak terdapat perbedaan antara produksi tebu petani mitra dan non mitra. Terdapat perbedaan antara pendapatan per hektar per tahun petani tebu mitra dan non mitra. Kemitraan dapat meningkatkan pendapatan petani, dengan jumlah produksi yang tidak jauh berbeda petani tebu mitra memperoleh pendapatan lebih tinggi daripada petani tebu non mitra.
PENGARUH ELEKTROLISER TERHADAP KEPEKAAN BAHAN BAKAR PADA MESIN DIESEL 1 SILINDER 20 HP
Authors: Sutomo Sutomo , Murni Murni , Senen Senen , Rahmat Rahmat 
Published: July 2019

Sutomo, Murni, Senen, Rahmat, Electrolyzer is development of a electrolysis technology to produce HHO gas, or Brown’s gas. Diesel engine use solar (diesel oil) as combustion’s material to produce thermal energy and oxidation and will be changed to mechanic energy. The base product of thermal energy by oxidation diesel oil, is would like to use electrolyzer to produce HHO and insert to the fuel combustion. Because HHO is a reactive gas, so in our research we hopeful will increase the thermal energy in combustion process and decrease the diesel oil consumption. The result of this research is the BSFC (Brake Shat Fuel Consumption) will decrease 2.5% up to 3.2%. Key word: electrolyzer, diesel engine, BSFC
PENGELOLAAN KUALITAS UDARA DI PERKOTAAN
Authors: Suyanto Hadi 
Published: July 2019

Hadi Suyanto, in this paper explain that to avoid global warming and climate change effect, re-greening program at the open and dry area need to be established, this also to generate fresh temperature and improve health and comfort. Develop and enlarge green zone and public zone as part of air quality management that have social and environmental function, and not just as an esthetically function. Keyword: Air Quality, re-greening
SIMULASI SISTEM EKSITASI UNTUK KONDENSATOR SINKRON PADA PEMBANGKIT LISTRIK TENAGA ANGIN
Authors: Sukmadi Tejo 
Published: July 2019

Tejo Sukmadi, in paper a model of wind energy power generation excitation system will be simulated. The focuse was on the modelling and parameters optimization of the DC1A type excitation systems for synchronous condenser as voltage regulation on the power plant. Excitation system optimization is made by using genetic algorithms method. The parameters optimization should have the optimal combination and the voltage regulation of wind energy power plants model find the best vale when there is a change in the wind speed. The simulation and analysis found that systems with excitation system parameterized combination of genetic algorithms experiment using crossovers opportunities 0.6 and mutations opportunities 0.032, which Ka = 297.2350, Ke = 0.6162, Kf = 0.01, Ta = 0.01, Te = 0.01 and Tf = 0.6278 is the best combination of excitation parameters obtained. By generating the 115.6604 ITAE value, over shoot 1,54%, steady state 0,44 s, the smallest voltage value after wind speed change is 0.9957 pu and the largest voltage value after wind speed change is 1.0025 pu. Keywords : wind energy power generation, excitation system, synchronous condenser, genetic algorithms.
Menyelami Metode Pendidikan Humanistik Sosaku Kobayashi Dalam Novel Totto Chan: The Little Girl At The Window Karya Tetsuko Kuroyanagi
Authors: Krissandi Apri Damai Sagita 
Published: July 2019

(Understanding The Education Method Of Sasoko Kobayashi In Novel Totto Chan: The Little Girl At The Window By Tetsuko Kuroyanagi) This study was aimed to describe the humastic educational method applied by Sosaku Kobayashi at Tomoe Gakuen school in Totto Chan's novel: The Litle Girl At The Window by Tetsuko Kuroyanagi. The method used in this research was descriptive. Based on the analysis of the study of Totto Chan's novel: The Litle Girl At The Window by Tetsuko Kuroyanagi, it can be concluded that the educational method applied by Sosaku Kobayashi at Tomoe Gakuen school was a method of humanistic education including ways to create authentic personality such as (1) strengthen students' confidence in giving meaning to life (2) paving the way for self-development, based on freedom and responsibility, (3) guiding learners to find life with self-motivation and desire to become more, (4) developing a worldview in a way original and expression in accordance with the students themselves. The four things can be seen through the learning activities in the classroom, learning activities outside the classroom, school rules, and the role of educators in learning.
Strategi Dagang Dan Permasalahan Toko Jepang Di Hindia Belanda Sebelum Perang Dunia II
Authors: Wardoyo Stedi 
Published: July 2019

(Title: Strategy Of Commerce And Issues Of Japan Shop In The Netherlands Indies Before World War II) The early of 20th century was a turning point of Japanese economic activities in Dutch East Indies, along with increasing number of Japanese population, especially in Java. In that era, Japanese trading activities that dominated by Japanese goods pitchman like textiles, drugs, soap and the other daily necessary untill suburb of Java, changed into permanent economic activities in the form of a small shop that popular among Javanese society in that era as Toko Jepang or Japanese Store. In the end of 1910 untill early 1940s, Japanese store’s activities were growing and increasing to become an icon in the economic relation between Japan and Dutch East Indies. During that period, there was increase and decrease in Japanese store’s activities, but at the world economic crisis in 1920s, Japanese Market was able to survive, even Japanese products from Japanese Store was better than Chinese and European products. Japanese store, that popular among indigenous was known for it’s good service, cheap price and good quality products. This research is trying to find how Japanese store can build it’s connection and the factors that supporting and obstacling Japanese store’s growth in that era. In this research, besides the diaries of Japanese immigrants such as Jagatara Kanwa and Nanyou no Seikatsu Kiroku, Japanese newspaper of Touindo Nippou was used as main sources. Content analysis was applied as a method to determine the contents in those sources which were relevant to the topic of this research. It can be concluded that the success keys of Japanese store was marketing strategies that supported by a strong trade connection, beside another factors like the success of observing people’s needs and product marketing strategy.
PEMILIHAN PEMASOK DAN PENENTUAN KUANTITAS PESAN PAKAN TERNAK MENGGUNAKAN MULTI OBJECTIVE LINEAR PROGRAMMING
Authors: Ratnasari Sintya , Diesya Stephani , P. Yogie Budi , Yuniaristanto Yuniaristanto , Sutopo Wahyudi 
Published: July 2019

Artikel ini merupakan pengembangan dari artikel Musyafak, dkk (2012) yang membahas mengenai penilaian kinerja supplier pakan ternak menggunakan Analytic Network Process(ANP) dan Rating Scale (Studi kasus PT. DMC, Malang, Jawa Timur). PT. DMC merupakan perusahaan yang bergerak dalam bidang peternakan yang memerlukan pakan ternak dari pihak ketiga. Dalam artikelnya, Musyaffak, dkk sudah melakukan penilaian kinerja dari masing-masing pemasok tetapi belum menggunakan penilaian tersebut sebagai bahan pertimbangan untuk menentukan jumlah pesanan pakan ternak yang optimal. Saat ini terdapat tiga pemasok yang bekerja sama dengan perusahaan sehingga pemilihan pemasok merupakan hal yang penting bagi departemen pembelian. Enterprise Resource Planning(ERP) sistem dalam proses pemilihan pemasok dapat menghasilkan penyimpanan biaya dan waktu. Artikel ini bertujuan untuk penentuan pemasok dan jumlah pakan ternak yang harus dipesan pada setiap pemasok dengan menggunakan Multi Objective Linear Programming. Model tersebut dikembangkan berdasarkan tiga kunci utama ERP. Fungsi Tujuan dari model untuk meminimasi biaya, defect rate, delivery delay rate dan supplier rate. Model dipecahkan dengan bantuan Microsoft Excel Solver Software. Hasil menunjukan, pesanan untuk ketiga pemasok adalah 100, 100 dan 32 tons.
KAJIAN SEMANTIK KATA ‘DAMAI SEJAHTERA’ DALAM BAHASA INDONESIA
Authors: Supatra Hendarto 
Published: July 2019

There is no expression Damai Sejahtera in Kamus Besar Bahasa Indonesia. In this dictionary we can find the meaning of damai and the meaning of sejahtera. That proves that DS is not a word but a phrase. In fact DS is not difference with damai dan sejahtera. The phrase that found in the Bible (John 14, verse 27) and commonly used among Indonesian Christians get its equivalent peace in English Bible and tentrem rahayu in Javanese Bible. Peace that commonly translated damai in Indonesian si not true in Indonesian Bible. Damai Sejahtera discussed in this article got its original concept from ancient Christian society not from English. That must be the reason. Budhism use the word bahagia meaning spiritual bliss with a special meaning which is not exactly the same with that that is used among Christian. So beside its common meaning used and known by all Indonesian people, speakers of bahasa Indonesia, DS also has specific meanings among Indonesian subculture like Budhis community, Muslim community, Christian community, etc.