bluuebunny/crossref_metadata_2025_split huggingface dataset:
Radiographic Evaluation and Comparison of Plate Fixation after Triple Pelvic Osteotomy in 32 Dogs with Hip Dysplasia
Authors: Hazewinkel H. A. W. , Nap R.C. , Meij B.P. , Wolvekamp W. Th. C. , Koch D. A. 
Published: March 2018

SummaryTriple pelvic osteotomy (TPO), as a treatment for canine hip dysplasia, was evaluated radiographically in 38 cases. Several parameters on radio-graphs of the pelvis, taken pre- and postoperatively, as well as six weeks and three months after the operation, were measured and compared. The results were also compared between iliac osteotomy fixation with the canine pelvic osteotomy plate (CPOP, n = 16) and the twisted dynamic compression plate (DCP, n = 22). Acetabular support (from 0.21 to 0.89), Norberg angle (from 77.6° to 111.8°) and hip joint congruence improved significantly after TPO. Dorsal pelvic width did not change, whereas, due to rotation, ventral pelvic width decreased to 80% of its pre-operative value. Osteophyte formation was judged to be moderate three months after the operation. Comparison of the two plating methods showed significant postoperative advantages for the CPO P group in terms of a higher Norberg angle and a better congruence. There was some loosening of 33% of the screws in both groups, but this did not interfere with the aim of the TP O procedure.The effect of triple pelvic osteotomy, as a treatment for canine hip dysplasia, was investigated retrospectively by means of radiographs. Acetabular support, the Norberg angle, and hip joint congruence improved significantly after the operation. Iliac osteotomy fixation, with the canine pelvic osteotomy plate, displayed advantages over the twisted dynamic compression plate. Screw loosening occurred frequently but without any major consequences.
Implant Complications in 20 Triple Pelvic Osteotomies
Authors: Fries Cindy , Remedios Audrey 
Published: March 2018

SummaryIn 12 dogs with hip dysplasia, 20 triple pelvic osteotomies (eight bilateral and four unilateral) were performed. Screw loosening, occurring in six of 12 dogs (seven of 20 osteotomies), was the most common complication after surgery. Implants loosened from the cranial ilium in six hemipelvises (30%) and from both fragments in one hemipelvis, two to six weeks (mean — three) after the operation. Medial acetabular displace-ment caused pelvic narrowing (6 to 9%, mean = 8%) in three of four dogs. Medial ischial displacement decreased pelvic diameter (11 to 21%, mean = 17%) in four of seven osteotomies. All of the dogs with implant failure were treated conservatively with cage rest and in two cases Ehmer slings were used. Although none were lame, gait abnormalities were evident in three of seven dogs on follow-up examinations four to 12 months (mean = six) later.Screw loosening, occurring in seven of 20 hemipelvises, was the most common postoperative complication associated with triple pelvic osteotomy. Fixation failures were managed conservatively. Despite decreased pelvic diameter in four of seven animals, none were lame or showed signs of pelvic obstruction at follow-up examinations four to 12 months later.
Clinical Case Applications of Mitek® Tissue Anchors in Veterinary Orthopaedics
Authors: Taylor R. A. , Franceschi Ruth A. , Edwards M. R. 
Published: March 2018

SummaryThe Mitek®a tissue anchor is a new device designed for reattaching avulsed tendons, ligaments and joint capsule to bone. This device has proven useful in human orthopaedics. Initially approved for use in Bankart repair (reattachment of glenohumeral ligament to anterior glenoid rim) procedures (1-3), the Mitek® anchor is now utilized in ligamentous repairs and tenodesis of the foot, ankle (4, 5) and wrist (6, 7). These devices have the advantages of biocompatibility, small size, impressive pullout strength, versatility and ease of application (8). In this study Mitek® anchors were used to repair avulsed or ruptured tarsal and phalangeal collateral ligaments, coxofemoral luxations and to provide stability to cruciate deficient stifles.This paper describes the use of Metek® tissue anchors to repair tendinous, ligamentous, and joint capsule ruptures and avulsions.
Does Fracture Pattern Influence Thoracic Trauma?
Authors: Dyce J. , Houlton J. E. F. 
Published: March 2018

SummaryThe case records of 300 dogs presented for fracture repair following road traffic accident (RTA) or other trauma were studied to determine possible relationships between specific patterns of skeletal trauma and the prevalence of thoracic wall and pulmonary injury.A significantly greater proportion of dogs involved in RTA (31%) sustained thoracic trauma compared ro those injured by other means (2.4%). Although RTA cases were more likely to suffer multiple fractures (23%), there was no significant relationship between the incidence and distribution of a fracture(s) and radiographic evidence of thoracic trauma.Of those dogs with thoracic trauma, pneumothorax and pulmonary contusion were the most frequent injuries; more than one type of injury occurred in 43% of these cases.Clinical management was altered as a result of thoracic injury in 24% of these cases.In a retrospective survey of 300 dogs presented for fracture repair, there was no significant relationship between fracture pattern and the prevalence of thoracic trauma. Following road traffic accident, radio-graphic examination revealed thoracic trauma in 31% of dogs. Clinical management was modified as a result of thoracic injury in 24% of cases.
Fragmented Coronoid Process Associated with Premature Distal Radial Physeal Closure in Four Dogs
Authors: Lewis D.D. , Johnson K.A. , Allen G.S. , Yovich Jane , Macpherson G. C. 
Published: March 2018

SummaryFragmented coronoid process occurred in four dogs with humeroradial subluxation secondary to premature closure of the distal radial physis. The medial coronoid process was affected in three dogs but in the fourth dog a single osteochondral fragment was located between the medial and lateral coronoid processes. One dog was treated by medial arthrotomy and lengthening of the radius. In three dogs the fragment was removed via a lateral arthrotomy accomplished by proximal ulnar diaphyseal osteotomy and the ulna was shortened at the ulnar osteotomy site to provide congruity of the proximal radio-ulnar and humeroradial articulations. The longterm clinical results were encouraging. The role of mechanical loading on the coronoid process in the pathogenesis of these cases is discussed.Four mature dogs were found to have fragmented coronoid process and humeroradial subluxation secondary to premature closure of the distal radial physis.It is proposed that the humero-radial subluxation placed ab-normal mechanical stress on the coronoid process of the ulna and caused its fracture or fragmentation.
The Adjunctive Use of Half-Pin (Type I) External Skeletal Fixators in Combination with Intramedullary Pins for Femoral Fracture Fixation
Authors: Schwarz P. D. , Salman M. D. , Foland Melissa 
Published: March 2018

SummaryA half-pin (type I) external skeletal fixator was used in conjunction with an intramedullary pin(s) for management of 29 femur fractures in 15 dogs and 14 cats. Eighty percent of the dogs and 100% of the cats achieved bony union using this combination of implants. However, because of the development of major complications which permanently impaired limb function (e.g. quadriceps tie-down), only 67% of the dogs and 93% of the cats were considered to have successful outcomes. The overall complication rate was 87% for dogs and 43% for cats. Dogs weighing <6.8 kg had a significantly lower complication rate than dogs weighing ≥6.8 kg. Dogs < one year of age were significantly more likely to develop a major complication resulting in an unsuccessful outcome, than dogs ≥ one year of age. A significant association was not established between any of the study variables and the complication incidence in cats.
Entwicklung und Umsetzung eines integrierten Versorgungsprojektes aus der Sicht eines Trägers
Authors: Steckermaier H. 
Published: March 2018

ZusammenfassungDie Integrierte Versorgung nach § 140 a ff SGB V erhält auch in der psychiatrischen Versorgungslandschaft zunehmend Relevanz. Gemessen an der Patientenzahl, kann das von der Techniker Krankenkasse (TK) initiierte “NetzWerk psychische Gesundheit” (NWpG) als deutschlandweit eines der größten integrierten Versorgungsprojekte im psychiatrischen Bereich bezeichnet werden. Seit langem geforderte Versorgungsangebote wie “Hometreatment” oder “Rückzugsräume” können damit erstmals nachhaltig und integriert realisiert werden.Für die Vertragspartner der TK – überwiegend Gemeindepsychiatrische Träger – ergeben sich jedoch neuartige Herausforderungen zur Umsetzung dieses Projektes. Neben den geringen Erfahrungswerten mit einer populationsorientierten integrierten Versorgung und einer auf einem Capitationsystem basierenden Finanzierungslogik, sind neue Herausforderungen in der praktischen Patientenarbeit zu bewältigen.Für Gemeindepsychiatrische Träger eröffnen sich dennoch vielfältige Möglichkeiten, jahrzehntelange Forderungen nach einer bedürfnisorientierten ambulant aufsuchenden Versorgung umzusetzen und die weitere gemeindepsychiatrische Entwicklung aktiv mitzugestalten.
Stabiler Verlauf einer hochaktiven schubförmigen MS unter Natalizumab seit mehr als 4 Jahren
Authors: Meuth S. , Ruck T. 
Published: March 2018

Zusammenfassung
Gegenstand und Ziel: Anhand eines Fallberichtes einer Patientin mit einer hochaktiven schubförmigen Multiplen Sklerose, deren Erkrankung unter einer Langzeittherapie mit Natalizumab anhaltend stabilisiert werden konnte, sollen die Überlegungen zu Nutzen und Risiken der Natalizumabtherapie verdeutlicht werden. Material und Methoden: Dem Fallbericht werden Anamnese, klinische Befunde sowie MRT-Aufnahmen zugrunde gelegt. Ergebnisse: Unter der Therapie mit Natalizumab konnte eine anhaltende Stabilisierung des Krankheitsverlaufes ohne klinische und paraklinische Krankheitsaktivität über den Zeitraum von 54 Infusionszyklen erreicht werden. Bis auf nicht behandlungsbedürftige Infektionskrankheiten konnten keine schweren Nebenwirkungen eruiert werden. Schlussfolgerungen/klinische Relevanz: Eine langjährige Therapie mit Natalizumab, über 24 Monate hinweg, ist abhängig vom initialen Krankheitsverlauf, dem Ansprechen auf die Therapie, der Risikostratifzierung einer PML und dem individuellen Patientenwunsch auch trotz erhöhter Risiken zu erwägen.
Methods for Predictor Analysis of Repeated Measurements: Application to Psychiatric Data
Authors: Eisenacher M. , Riesbeck M. , Gaebel W. , Köpcke W. , Seuchter S. A. ,   and other members of the A.N.I. Study Group
Published: March 2018

Summary

Objectives:
In schizophrenia research, little attention yet has been directed on methods for analyzing data from studies with repeated measurements over time. Motivation for this research stems from a project within the German Research Network on Schizophrenia, in which an algorithm is developed to guide prodrome-based early intervention strategies in stable first episode patients.

Methods:
We present two different approaches for the analysis of correlated response data, the Generalized Estimating Equations (GEE) method and the Artificial Neural Network (ANN) approach. We illustrate the methods using the data of the A.N.I. study, which is one of the largest German multicenter treatment studies in regard to the long-term treatment of schizophrenia conducted between 1983 and 1989.

Results:
The results of statistical model selection prior to GEE analysis and various data presentation methods for ANNs are presented. The primary goal of our evaluation is to investigate if the defined prodromes are valid predictors for relapse. Additionally, it is shown that both methods are applicable on a realistic data set.

Conclusions:
It is concluded that both methods are suitable for predictor analysis especially since all variable time points of the patients are included instead of only selected, so that it can be assumed that results are not biased. With the GEE method a test of association for each predictor can be performed whereas with ANNs a general proposition can be made for pro-dromes depending on the type of data presentation. Using the A.N.I. data the prodrome ‘trouble sleeping’ seems to be the most informative predictor. Finally, the important differences of the two methods are discussed.
Forecasting of Life Threatening Arrhythmias Using the Compression Entropy of Heart Rate
Authors: Baumert M. , Baier V. , Haueisen J. , Wessel N. , Meyerfeldt U. , Schirdewan A. , Voss A. 
Published: March 2018

Summary

Objectives:
Ventricular tachycardia (VT) provoking sudden cardiac death (SCD) are a major cause of mortality in the developed countries. The most efficient therapy for SCD prevention are implantable cardioverter defibrillators (ICD). In this study heart rate variability (HRV) measures were analyzed for short-term forecasting of VT in order to improve VT sensing and to enable a patient warning of forthcoming shocks.

Methods:
The last 1000 normal beat-to-beat intervals before 50 VT episodes stored by the ICD were analyzed and compared to individually acquired control time series (CON). HRV analysis was performed with standard parameters of time and frequency domain as suggested by the HRV Task Force and furthermore with a newly developed and optimized nonlinear parameter that assesses the compression entropy of heart rate (Hc).

Results:
Except of meanNN (p = 0.02) we found no significant differences in standard HRV parameters. In contrast, Hc revealed highly significant (p = 0.007) alterations in VT compared with CON suggesting a decreased complexity before the onset of VT.

Conclusion:
Compression entropy might be a suitable parameter for short-term forecasting of life-threatening tachycardia in ICD.
An Inventory of Evaluation Studies of Information Technology in Health Care
Authors: de Keizer N. , Ammenwerth E. 
Published: March 2018

Summary

Objectives:
During the last years the significance of evaluation studies as well as the interest in adequate methods and approaches for evaluation has grown in medical informatics. In order to put this discussion into historical perspective of evaluation research, we conducted a systematic review on trends in evaluation research of information technology in health care from 1982 to 2002.

Methods:
The inventory is based on a systematic literature search in PubMed. Abstracts were included when they described an evaluation study of a computer-based component in health care. We identified 1035 papers from 1982 to 2002 and indexed them based on a multi-axial classification describing type of information system, study location, evaluation strategy, evaluation methods, evaluation setting, and evaluation focus.

Results and Conclusions:
We found interesting developments in evaluation research in the last 20 years. For example, there has been a strong shift from medical journals to medical informatics journals. With regard to methods, explanatory research and quantitative methods have dominated evaluation studies in the last 20 years. Since 1982, the number of lab studies and technical evaluation studies has declined, while the number of studies focusing on the influence of information technology on quality of care processes or outcome of patient care has increased. We interpret this shift as a sign of maturation of evaluation research in medical informatics.
The EpiLink Record Linkage Software
Authors: Tittarelli A. , Tagliabue G. , Maghini A. , Fabiano S. , Crosignani P. , Tessandori R. , Contiero P. 
Published: March 2018

Summary

Objectives:
Record linkage, the process of bringing together separately compiled but related records from different databases, is essential in many areas of biomedical research. We developed a record linkage program (EpiLink), which employs a simple mathematical approach. We describe the program and present results obtained testing it in a linkage task.

Methods:
EpiLink was designed to be flexible with user-friendly settings to tailor linkage and operating parameters to specific linkage tasks, and employ deterministic, probabilistic or sequential deterministic-probabilistic linkage strategies as required. The user can also standardize data format, examine linkage results and accept or discard them. We used EpiLink to link a subset of cases of the Lombardy Cancer Registry (20,724 records) with the Social Security file of the population (1,021,846 records) covered by the registry. The linkage strategy was deterministic, followed by several probabilistic linkage steps.

Results:
Manual inspection of the results showed that EpiLink achieved 98.8% specificity and 96.5% sensitivity.

Conclusions:
EpiLink is a practical and accurate means of linking records from different databases that can be used by non-statisticians and is efficient in terms of human and financial resources.
Time-variant Parametric Estimation of Transient Quadratic Phase Couplings during Electroencephalographic Burst Activity
Authors: Eiselt M. , Schelenz C. , Witte H. , Schwab K. 
Published: March 2018

Summary

Objectives:
Electroencephalographic burst activity characteristic of burst-suppression pattern (BSP) in sedated patients and of burst-interburst pattern (BIP) in the quiet sleep of healthy neonates have similar linear and non-linear signal properties. Strong interrelations between a slow frequency component and rhythmic, spindle-like activities with higher frequencies have been identified in previous studies. Time-varying characteristics of BSP and BIP prevent a definite pattern-related analysis. A continuous estimation of the bispectrum is essential to analyze these patterns. Parametric bispectral approaches provide this opportunity.

Methods:
The adaptation of an AR model leads to a parametric bispectrum by using the transfer function of the estimated AR filter. Time-variant parametric bispectral approaches require an estimation of AR parameters which consider higher order moments to preserve phase information. Accordingly, a time-variant parametric estimation of the bispectrum was introduced. Data driven simulations were performed to provide optimal parameters. BSP (12 patients) and BIP (6 neonates) were analyzed using this novel approach.

Results:
Significant differences in the time course of burst pattern during BSP and burst-like pattern before the onset of BSP could be shown. A rhythmic quadratic phase coupling (period 10 sec) was identified during BIP in all neonates.

Conclusion:
Quadratic phase couplings during BSP increases in the time course depending on depth of sedation. The visually detected burst activity in BIP is only the temporarily observable EEG correlate of a hidden neural process. Time-variant bispectral approaches offer the possibility of a better characterization of underlying neural processes leading to improved diagnostic tools used in clinical routine.
Sample Selection for Microarray Gene Expression Studies
Authors: Repsilber D. , Fink L. , Jacobsen M. , Bläsing O. , Ziegler A. 
Published: March 2018

Summary

Objectives:
The choice of biomedical samples for microarray gene expression studies is decisive for both validity and interpretability of results. We present a consistent, comprehensive framework to deal with the typical selection problems in microarray studies.

Methods:
Microarray studies are designed either as case-control studies or as comparisons of parallel groups from cohort studies, since high levels of random variation in the experimental approach thwart absolute measurements of gene expression levels. Validity and results of gene expression studies heavily rely on the appropriate choice of these study groups. Therefore, the so-called principles of comparability, which are well known from both clinical and epidemiological studies, need to be applied to microarray experiments.

Results:
The principles of comparability are the study-base principle, the principle of deconfounding and the principle of comparable accuracy in measurements. We explain each of these principles, show how they apply to microarray experiments, and illustrate them with examples. The examples are chosen as to represent typical stumbling blocks of microarray experimental design, and to exemplify the benefits of implementing the principles of comparability in the setting of micro-array experiments.

Conclusions:
Microarray studies are closely related to classical study designs and therefore have to obey the same principles of comparability as these. Their validity should not be compromised by selection, confounding or information bias. The so-called study-base principle, calling for comparability and thorough definition of the compared cell populations, is the key principle for the choice of biomedical samples and controls in microarray studies.
Are Structured Data Structured Identically?
Authors: Roukema J. , van Ginneken A. M. , de Wilde M. , van der Lei J. , Los R. K. 
Published: March 2018

Summary

Objective:
OpenSDE is an application that supports structured recording of narrative patient data to enable use of the data in both clinical practice and clinical research. Reliability and accuracy of collected data are essential for subsequent data use. In this study we analyze the uniformity of data entered with OpenSDE. Our objective is to obtain insight into the consensus and differences of recorded data.

Methods:
Three pediatricians transcribed 20 paper patient records using OpenSDE. The transcribed records were compared and all recorded findings were classified into one of six categories of difference.

Results:
Of all findings 22% were recorded identically; 17% of the findings were recorded differently (predominantly as free text); 61% was omitted, inferred, or in conflict with the paper record.

Conclusion:
The results of this study show that recording patient data using structured data entry does not necessarily lead to uniformly structured data.
Identification of Adverse Drug Reactions by Evaluation of a Prescription Database, Demonstrated for “Risk of Bleeding”
Authors: Westendorf J. , Diebow R. , Kieser M. , Gaus W. 
Published: March 2018

Summary

Objective:
Information about adverse drug reactions plays an important role when assessing the benefit/risk profile of a drug. Identifying rare adverse drug reactions, however, is a difficult task. This paper illustrates the advantages of using a prescription database for this purpose.

Methods:
The mediplus® database used in our analysis covered data from 320,644 outpatients observed between July 1999 and June 2002. The example of bleeding complications during intake of antidementia drugs is used to illustrate this approach. The comparison of cohorts and subgroups is nearly always a problem in surveys. For our analyses we considered a set of patients who had taken a selected medication for a certain period of time and compared the frequency of adverse events with those occurring when the same patients did not take this medication. Hence, the comparison with versus without a certain medication is based on the same set of patients as in a cross-over study.

Results:
Our evaluations indicate that the rate of bleeding complications is low when taking any of the widely used antidementia drugs, glutamate modulators, cholinesterase inhibitors, calcium antagonists or the phytomedicine Ginkgo biloba.

Conclusion:
Basing the comparison of the rates of complications during periods with and without intake of a certain drug on the same set of patients may be a useful tool for assessing adverse drug reactions from data reported in prescription databases.