bluuebunny/crossref_metadata_2025_split huggingface dataset:
An assessment of PCV13 vaccine coverage using a repeated cross-sectional household survey in Malawi
Authors: Bondo Austin , Nambiar Bejoy , Lufesi Norman , Deula Rashid , King Carina , Masache Gibson , Makwenda Charles , Costello Anthony , Rhoda Dale , McCollum Eric D. , Colbourn Tim 
Published: August 2018

Background: The 13-valent pneumococcal conjugate vaccine (PCV13) was introduced in Malawi from November 2011 using a three dose primary series at 6, 10, and 14 weeks of age to reduce Streptococcus pneumoniae-related diseases. To date, PCV13 paediatric coverage in Malawi has not been rigorously assessed. We used household surveys to longitudinally track paediatric PCV13 coverage in rural Malawi. Methods: Samples of 60 randomly selected children (30 infants aged 6 weeks to 4 months and 30 aged 4-16 months) were sought in each of 20 village clinic catchment ‘basins’ of Kabudula health area, Lilongwe, Malawi between March 2012 and June 2014. Child health information was reviewed and mothers interviewed to determine each child’s PCV13 dose status and vaccine timing. The survey was completed six times in 4-8 month intervals. Survey inference was used to assess PCV13 dose coverage in each basin for each age group. All 20 basins were pooled to assess area-wide vaccination coverage over time, by age in months, and adherence to the vaccination schedule. Results: We surveyed a total of 8,562 children in six surveys; 82% were in the older age group. Overall, in age-eligible children, two-dose and three-dose coverage increased from 30% to 85% and 10% to 86%, respectively, between March 2012 and June 2014. PCV13 coverage was higher in the older age group in all surveys. Although it varied by basin, PCV13 coverage was consistently delayed: median ages at first, second and third doses were 9, 15 and 21 weeks, respectively. Conclusion: In our rural study area, PCV13 introduction did not meet the Malawi Ministry of Health one-year three-dose 90% coverage target, but after 2 years reached levels likely to reduce the prevalence of both invasive and non-invasive paediatric pneumococcal diseases. Better adherence to the PCV13 schedule may reduce pneumococcal disease in younger Malawian children.
Nurses' approaches to ethical dilemmas: An example of a public hospital <p>Hemşirelerin etik ikilemlere yaklaşımları: Bir kamu hastanesi örneği
Authors: Demirsoy Nilüfer , Türe Yılmaz Aysun , Şaylıgil Ömür 
Published: August 2018

Aim: In this study, the ethical conflicts faced by the nurses working in the secondary health care facility in Eskişehir were investigated with the Nursing Ethical Dilemma Test .Method: It was a descriptive study. 233 nurses working in a secondary health care facility in Eskişehir were reached. The data were evaluated in the SPSS-21.00 statistical program,Pearson correlation and descriptive statistical techniques were used in the analysis.Findings: The average age is 32,53 ± 6,23. Nurses' Principle Thinking average point (17,64 ± 11,34); Practical Thinking average point (6,16± 5,07) ; acquaintance average point (13,86± 3,91) was determined that found to be well below the average in every three types of points.Conclusion: When the obtained data were analyzed,it was determined that the nurses frequently encountered situations with ethical problems during their professional lives,but they were nor sufficient to take ethical principles into account when deciding an ethical issues,and the most basic reason was not at the level of prefence with environmental factors. Extended English summary is in the end of Full Text PDF (TURKISH) file.ÖzetAmaç: Bu araştırmada Eskişehir ilinde İkinci basamak sağlık kurumunda çalışan hemşirelerin karşı karşıya kaldıkları etik ikilemlerin, “Hemşirelik Etik İkilem Testi’ile düzeylerinin incelenmesi amaçlanmıştır.Metod: Araştırmanın tipi tanımlayıcıdır. Eskişehir’de İkinci basamak sağlık kurumunda çalışan 233 hemşireye ulaşılmıştır. Veriler SPSS-21.00 istatistik programında değerlendirilmiş, analizinde Pearson korelasyonu ve tanımlayıcı istatistik teknikleri kullanılmıştır.Bulgular: Hemşirelerin Yaş ortalaması 32,53 ± 6,23’dir. Hemşirelerin İlkesel Düşünme (İD) puan ortalaması (17,64 ± 11,34) ; Pratik Düşünme (PD) puan ortalaması (6,16 ± 5,07);Aşinalık puan ortalaması (13,86± 3,91) olarak[N1] belirlenmiş, her üç puan türünde de ortalamanın çok altında puan aldıkları tespit edilmiştir.Sonuç: Elde edilen veriler analiz edildiğinde, hemşirelerin mesleki yaşantıları süresince sıklıkla etik sorun içeren durumlarla karşılaşmış olduğu, fakat etik sorunlara yönelik karar verirken etik ilkeleri göz önünde bulundurma konusunda oldukça yetersiz oldukları, bunun en temel nedenin çevresel faktörler etkisi ile istendik düzeyde olmadığı belirlenmiştir.
Rootstock’s and scion’s impact on lemon quality in southeast Spain
Authors: Legua Pilar , Martinez-Cuenca Maria R. , Bellver Ricardo , Forner-Giner María Á. 
Published: August 2018

Abstract
In terms of growth, yield and fruit quality, three lemon varieties (‘Fino49’ F49, ‘Verna50’ V50 and ‘FinoElche’ FE) were tested on three new hybrid root stock selections (Forner-Alcaide 2324, Forner-Alcaide 418 and Forner-Alcaide 5). Yield was weighed within a nine year period and fruit quality was determined in two harvests. Tree size was similar on the Forner-Alcaide 5 and Forner-Alcaide 2324 rootstocks, but reduced by 50% on Forner-Alcaide 418. Forner-Alcaide 2324 and the Forner-Alcaide 5 rootstocks showed similar cumulative yield, while it was decreased by 66% in Forner-Alcaide 418. In all cases, ‘Verna50’ was the less efficient scion. Rootstock was found to significantly affect fruit quality variables. The Forner-Alcaide 418 rootstock induced the lowest peel thickness and peel percentage, but the highest juice content and colour index. Forner-Alcaide 5, together with Forner-Alcaide 418, showed the highest total soluble sugars. In conclusion, both the Forner-Alcaide 5 and Forner-Alcaide 2324 rootstocks generate standard tree size and high yield in the varieties tested, together with great fruit quality, being a suitable alternative for replacing C. macrophylla rootstock when used in lemon varieties. Forner-Alcaide 418 reduces tree size without decreasing yield efficiency and improves alternate-bearing of the harvest. Thus, it may have use in intensifying citrus production as it behaves as a dwarfing rootstock.
“An American near Rome” … and not only! Presence of the eastern cottontail in Central Italy and potential impacts on the endemic and vulnerable Apennine hare
Authors: Dori Paolo , Scalisi Marco , Mori Emiliano 
Published: August 2018

Abstract
The eastern cottontail Sylvilagus floridanus has been introduced to Italy for hunting purposes since the 1960s. This species is currently present in northern Italy, with some small populations in Central Italy. Data for Central Italy are scanty, but they deserve research attention because this lagomorph is responsible for the spread of disease to an endemic vulnerable species, the Apennine hare Lepus corsicanus. In this work, we summarized the distribution of alien cottontails, over 50 years after their first releases, with special regard to areas where the endemic species is present. Eradication should be recommended where the alien species coexists with the endemic one.
A report on the reports of the stanford literary lab: A reason why the digital humanities may find it difficult to change literary history
Authors: Candel Daniel 
Published: August 2018

AbstractThe present article studies eight of the twelve reports of the Stanford Literary Lab (SLL) to understand why the revolutionary practices of the lab, and by extension of the digital humanities, have not yet changed literary history, as the lab itself admits. The article examines the reports with two related cultural-semantic tools, each of which is introduced via the Pixar movieBrave. First, the interpretations of the reports are placed within a basic semantic grid organized into four quadrants by a nature-society axis and a past-present axis, which shows that the interpretations are invariably situated in the present-society quadrant. This analysis, while necessary, merely proves that SLL operates within a certain cultural climate. The real test lies in ascertaining whether this cultural climate affects the interpretation of novel data. To do so, the article looks for the reaction of SLL to novel data in two reports. The reports are shown to domesticate novelty by explaining it through standard alethic/deontic patterns, even though the data are novel precisely because the patterns largely fail to explain them. The article closes by asking whether such patterns limit or enable thinking and what this means for the digital humanities.
The Significance of Metabolic Energy and the Ion Pump for the Receptor Potential of the Crayfish Photoreceptor Cell
Authors: Stieve H. , Bollmann-Fischer H. , Braun B. 
Published: August 2018

Isolated crayfish retinas were poisoned by dinitrophenol (DNP) or ouabain (OU). The changes of the extracellularly recorded receptor potential (ReP) evoked by short or long stimuli were measured.
The changes of the shape of the ReP after poisoning by OU are the same, except the transient increase, as appear after depolarizing the retina by high external potassium concentration. DNP has different effects on the ReP. It causes a prolongation of the amplitude hmax and an increase of the shape quotient hmax/he (Fig. 9).
Expecially the rate of decrease of the excitability under different stimulus programs was measured (Tab. 5).
DNP experiments show that the inexcitability occurs the earlier the higher the incident light intensity is.
The time needed depends on the stimulating efficiency of the light rather than on the direct amount of energy.
The loss of excitability rather depends on the energy of the total light applied than on the stimulus pattern.
Concerning the inexcitability OU shows the same effect as DNP: it occurs the earlier the more the retina is excited.
These results contradict the hypothesis that the receptor potential is a consequence of a light induced change of the activity of an electrogenic pump mechanism. Fig. 10 shows the electrogenic pump mechanism (EPM) as opposed to the conductance increase mechanism (CIM).
Zur Reaktivität von Isocyanaten mit Tris(dimethylamino)arsin / The Reactivity of Isocyanates with Tris(dimethylamino)arsine
Authors: Roesky Herbbert W. , Sidiropoulos Georg 
Published: August 2018

As[N(CH3)2]3 reacts with the following isocyanates: FSO2NCO, n-C4F9SO2NCO, SO2(NCO)2 and (CH3)3SiNCO. The products which result from reaction of FSO2NCO and n-C4F9SO2NCO are the acyclic tri- and bisubstituted arsines
[xxx]
In contrast, SO2(NCO)2 and (CH3)3SiNCO form eight- and four-membered ring compounds, where the skeleton consists of the atoms As2S2N4 (3) and As2N2 (4). The new compounds were characterized by NMR and mass spectra.
Bis(diazadien)metall(O)-Komplexe, IV. Nickel(O)-bis(chelate) mit aromatischen N-Substituenten/ Bis(diazadiene)metal(O) Complexes, IV. Nickel(O)-bis(chelates) with Aromatic N-Substituents
Authors: Dieck Heindirk tom , Svoboda Michael , Greiser Thomas 
Published: August 2018

Abstract
With N-aromatic substituted diazadienes (DAD)

and R3 = R4 = aryl) nickel(O) forms complexes of composition (DAD)2Ni which are prepared preferably by reduction of Ni(II) salts in the presence of DAD. The groups R1, R2 and/or the o-substituents of the aryl system determine the conformation of the DAD and its sterical ligand properties. An X-ray structure analysis of (DAD)2Ni 17 (DAD = glyoxalbis( 2,6-dimethyl-phenylimine)) shows a dihedral angle of 44° between the two chelate planes. With twisted N-aryl substituents nickel seems to prefer planar coordination (formal low spin Ni(II)) of two DADs over tetrahedrally coordinated formal nickel(O) state.
Photochemical Reactions of Bromoanthracenes with N,N-Dimethylaniline in Solution
Authors: Fulara Jan , Latowski Tadeusz 
Published: August 2018

Abstract
Major products of the photolysis of 9-bromoanthracene and 9,10-dibromoanthracene in benzene and acetonitrile as well as photochemical reaction products of the two bromoanthracenes with N,N-dimethylaniline in these solvents have been isolated and identified. The mechanisms of partial reactions are discussed and attention is paid to the medium effect on the photochemical transformations.
Zur Darstellung und Kristallstruktur von Barium-1,1-dicyanoethylen-2,2-oxo-thiolat-Tetrahydrat — ein Salz mit dem Anion [O(S)CC(CN)2 ]2- / Synthesis and Crystal Structure of Barium-1,1-dicyanoethylene-2,2-oxo-thiolate Tetrahydrate — a Salt with the Anion [O(S)CC(CN)2]2-
Authors: Hummel Hans-U. 
Published: August 2018

Abstract
By reaction of COS with malonitrile in presence of potassium ethanolate in ethanol K2O(S)CC(CN)2 · H2O is obtained. It reacts with Ba(NCS)2 ·3H2O in ethanol to form colourless crystals of BaO(S)CC(CN)2 · 4H2O. The space group of the barium salt is Pn21a (standard: Pna21) with Z = 4. The structure consists of Ba2+ and [O(S)CC(CN)2 ]2 - ions. The barium ion is bound to three nitrogen and six oxygen atoms. The coordination polyhedron is a tricapped trigonal prism. The anion [O(S)CC(CN)2 ]2 - is not exactly planar and is involved in several hydrogen bondings.
Kaliumlithiumsulfid, KLiS: Das erste Interalkalimetallsulfid / Potassium Lithium Sulphide, KLiS: The First Inter Alkaline Metal Sulphide
Authors: Sabrowsky Horst , Thimm Alfred , Mertens Petra 
Published: August 2018

Abstract
The compound KLiS has been prepared and its crystal structure is determined by X-ray diffraction techniques. The hygroscopic, yellow compound crystallizes in the tetragonal space group P4/nmm (Z = 2) with the cell parameters a - 431.79(4), c = 696.20(9) pm. The structure was solved from 2100 counter reflections (356 symmetry independent reflections) through a Patterson synthesis and refinement by Fourier syntheses to a least squares residue of 0.026. The structure is characterized by c-centered squares of lithium layers interspersed by anti-parallel ordered K-S-pairs forming an anti-PbFCl-type geometry.
Cyclische Triphosphenium-Ionen: Selektiver intramolekularer Ligandenaustausch in einer nucleophilen Substitution am zweifachkoordinierten Phosphor [1] / Cyclic Triphosphenium Ions: Selective Intramolecular Exchange of Ligand in a Nucleophilic Substitution at the Two-Coordinate Phosphorus [1]
Authors: Lochschmidt Siegfried , Schmidpeter Alfred 
Published: August 2018

Abstract
Phenyl substituted di-, tri- and tetraphosphines with the donor-functions in 1,2- or 1,3-position effectively replace Ph3P from Ph3P-P-PPh3
+AlCl4
−yielding cyclic five- and six-membered triphosphenium cations. In the 1:1-products of PhP(-CH2-CH2-PPh2)2 (4) and MeC(-CH2-PPh2)3 (2) the unused third phosphine function may interact as a nucleophile with the central phosphorus leading to a threefold T-shaped or pyramidal coordination thereof, respec­tively. From this attack, in the former case only, a rapid intramolecular exchange (ΔH≠ = 9.6 kcal mol-1; ΔS≠= −9.9 cal mol-1 K-1) results, involving the two phosphine functions in the apical sites of the T-shaped transition geometry. This mechanism is suggested to describe the nucleophilic substitution at two-coordinate phosphorus in general. The cyclic triphosphenium cations can be protonated (and in part alkylated) to yield cyclic triphosphine-dionium cations.
Elektrochemisches Verhalten von Dibenzodichalkogeninen und verwandten Verbindungen / Electrochemical Behavior of Dibenzodichalcogenins and Related Compounds
Authors: Stende Klaus-Wilhelm , Klar Günter , Knittel Dierk 
Published: August 2018

Abstract
The electrochemical behavior of thianthrenes 1-4, of selenanthrenes 5-8 (dibenzo-1,4-dichal- cogenins). of 2,2′-dithiobiphenyls 9 and 10 (dibenzo-1,2-dichalcogenins) as well as of the related compounds 11-13 were studied by cyclic voltammetry in acetonitrile. All dibenzodichalcogenins can be [oxidised in two one-electron-steps, the processes being totally reversible for 7, nearly reversible for 2 and 9, quasireversible for 1, 3, 4,10 and 13, and irreversible in all other cases. For 1- 4, 7, 9, 10 and 13 the diffusion coefficients of the electrochemically active species and the rate constants of the electron transfer are calculated from the potentials measured. Electrolysis of 9 in dichloromethane with tetrabutylammonium perchlorate as supporting elec­trolyte yields [dithiobiphenyl] + [C104]- (14), while oxidation by nitrosyl hexachloroantimonate gives [(dithiobiphenyl)2] + [SbCl6]- (15).
Pentaalkyl-Derivate des 2 ,3 - Dihiydro-1,3-diborols/Pentaalkyl Derivatives of the 2,3-Dihydro-1,3-diborole
Authors: Knörzer G . , Siebert W. 
Published: August 2018

Abstract
Double hydroboration of acetylene, propyne-1 and t-butylacetylene with HBCl2 · OEt2/BCl3 leads to the 1,1-bis(dichloroboryl)alkanes 2d, e, f, in which halogen exchange is achieved by BI3 to give 3d, e, f. Redox reactions between butyne-2, hexyne-3 and 3 result in the formation of compounds 4, which are alkylated with AlMe3 and AlEt3 to give the pentaalkyl derivatives 1d, e, f. Reactions of 1 with [(C5H5)Co(C2H4)2] an [(C5H5)N iCO]2 lead to the complexes 5 and 6.
Design, Synthesis and Biological Evaluation of Antagonists of LHRH by Criteria of Potency, Safety and Solubility
Authors: Ljungqvist Anders , Feng Dong-Mei , Bowers Cyril , Hook William A. , Folkers Karl 
Published: August 2018

Some analogs of Antide and congeners with higher water solubility have been synthesized by substitutions in positions 1, 5 or 6 with hydrophilic residues. In position 1, D-3-Qal has been incorporated in four peptides and D-3-Pal in one peptide. In positions 5 and 6, D and L-3-Pal, PzAla and (DSer)Lys have been tried. In one peptide, D—(AcDSer)Lys was substituted in position 6.
Most of the new analogs had lower AOA (antiovulatory activity) than the parent compounds but three potent analogs were identified. The first one, [N — Ac— D — 3-Qal1,DpClPhe2,D— 3-Pal3,c-PzACAla5,D — PicLys6,ILys8,D — Ala10]— LHRH, had 55% AOA at 0.25 μg and 100% at 0.5 μg. Its ED50 for in vitro histamine release was 171 ± 17 μg/ml which is an increase from 49±4.8 μg/ml for the parent compound with N—Ac-D-2-Nal [1].
The second analog, [N — Ac— D — 2-Nal1,DpClPhe2,D — 3-Pal3,PicLys5,D — (DSer)Lys6,ILys8,D—Ala10] — LHRH, had 69% AOA at 0.25 μg and 95% at 0.5 μg. This analog released somewhat more histamine than the parent analog featuring D-PicLys6, the ED50 being 18 μg/ml compared to 93 ± 11 for the parent analog.
The third analog is:
[N — Ac— D— 2-Nal1,DpClPhe2,D— 3-Pal3,c-PzACAla5,D—PzAla6,ILys8,DAla1]— LHRH. The AOA for this analog was 63% at 0.25 μg and the ED50 for histamine release 88±6.4 μg/ml.
Synthese und Kristallstrukturen der neuen Zinn-Chalkogen-Vierringe [{Cp(Ph3P)Ni}2Cl2Sn2E2] (E = Se, S) / Synthesis and Crystal Structures of the New Four-M em bered Tin-Chalcogen Rings [{Cp(Ph3P)Ni}2Cl2Sn2E2] (E = Se, S)
Authors: Kraus Harald , Merzweiler Kurt 
Published: August 2018

Abstract
[{Cp(Ph3P)Ni}SnCl3] reacts with Se(SiMe3)2 within several days to give [{Cp4(Ph3P)3Ni5Sn6Se9] (1). If the reaction is stopped after 16h, green crystals of the intermediate [{Cp(Ph3P)Ni}2Cl2Sn2Se2] (2) can be isolated. According to the X -ray structure determination, 2 consists of a planar Sn2Se2 ring with terminal {Cp(Ph3P)Ni} and Cl substituents in a trans arrangement. The analogous reaction of [{Cp(Ph3P)Ni}SnCl3] with S(SiMe3)2 leads to the sulfur derivative [{Cp(Ph3P)Ni}2Cl2Sn2S2] 3 which has an analogous structure.
Die zu BaMg2Cu8V6O26 isotypen Cadmium-Kupferoxovanadate KCd0,67Cu4,33V3O13, RbCd0,5Cu4,5V3O13 sowie TlCd0,5Cu4,5V3O13 /The BaMg2Cu8V6O26 isotypic Cadmium-Cooperoxovanadates KCd0,67Cu4,33V3O13, RbCd0,5Cu4,5V3O13 and TlCd0,5Cu4,5V3O13 /
Authors: Mertens B. , Müller-Buschbaum Hk. 
Published: August 2018

Abstract
Single crystals of KCd0,67Cu4,33V3O13 (I), RbCd0,5Cu4,5V3O13 (II) and TlCd0,5Cu4,5V3O13 (III) have been prepared by crystallization from melts. X-ray analysis led to monoclinic symmetry, space group C2
2h-P21/m (Nr. 11) and the lattice constants (I) - (III): a = 10.728(1), 10.746(3), 10.746(3), b = 6.155(1), 6 .163(2), 6.175(2), c = 8.363(2), 8.350(2), 8.337(3) Å , β = 97.69(2), 97.73(2), 97.61(5)°, Z = 2. The crystal structures are isotypic to the BaMg2CU8V6 O26 type. Cu2+ occurs in square pyramidal and unusual trigonal bipyram idal coordination by oxygen . The MgO6 octahedra of the aristo type BaMg2Cu8V6O26 are statisti­cally occupied by cadmium and copper. The distortion of the (Cd /Cu)O6 octahedra is discus­sed with respect to the polyhedra network.
A Novel Access to Tertiary and Secondary ortho-Aminophenylphosphines by Protected Group Synthesis and Palladium Catalyzed P-C Coupling Reactions
Authors: Heßler Antonella , Kottsieper Konstantin W. , Schenk Stefan , Tepper Michael , Stelzer Othmar 
Published: August 2018

Abstract
The dilithium salt 1a formed by ortho-metallation of N-tert-butoxycarbonylaniline (BOC-aniline) 1 with two equivalents of tert-butyllithium reacts with the chlorophosphines Ph3-nPCln (n = 1 -3) to yield the BOC protected ortho-aminophenylphosphines 2 - 4 in high yields. On deprotection of 2 - 4 with trimethylchlorosilane in the presence of phenol the HCl adducts of the ortho-aminophenylphosphines 5 -7 are formed which may be deprotonated with KOH or NaOH to give the neutral phosphines 5a -7a. The novel secondary phosphine 8 with two ortho-aminophenyl groups is accessible by cleavage of the P-C bond in 7a with metallic lithium and subsequent hydrolysis. The bifunctional P,N ligands 6 or 6a are alternatively accessible by Pd-catalyzed P-C coupling of ortho-iodoaniline with phenylphosphine. If a 1:1 stoichiometry is employed in the coupling reaction of ortho-iodoaniline and phenylphosphine the chiral secondary phosphine 9 is formed.
X-Ray Structure of 6(E)-[2(Z)-(Hydroxyimino)-2-phenylethyIidene]- 7,7,8,8,9,9-hexamethyl-3-phenyl-1,2-oxazaspiro[4.4]non-2-ene
Authors: Borowiak Teresa , Wolska Irena , Mayr Herbert , Baran Janusz 
Published: August 2018

Abstract
The X-ray crystallographic structure of the title compound, a product of a 1,3-dipolar cy­ cloaddition reaction of benzonitrile oxide to 3,3,4,4,5,5-hexamethyl-1,2-bis(methylene)cyclopentane, has been determined. Colourless plates crystallize in the orthorhombic space group Pbca with cell dimensions a = 13.698(2), b = 11.836(2), c = 29.157(4) Å, V= 4727.2(1.2)Å3, Z = 8, 3736 reflections, final R(F) = 0.063 and wR(F2) = 0.166. The crystals are racemic, the molecules of opposite chirality form centrosymmetric dimers via intermolecular hydro­ gen bonds O-H···N between their oxime groups. The molecules are highly strained and the geometrical consequences of the steric strain are discussed.
Synthesis and Structural Characterization of Aminoalkanol Derivatives of 2,3-Dihydro-2,2-dimethyl-7-benzofuranol with an Expected β-Adrenolytic and / or Anxiolytic Activity
Authors: Kossakowski Jerzy , Hejchman Elżbieta , Wolska Irena 
Published: August 2018

Abstract
A series of fifteen new N-substituted derivatives of 2,3-dihydro-2,2-dimethyl-7-benzofuranol have been prepared and studied by IR and 1H NMR spectroscopy. In addition the crystal structures of 7-[3-[4-(4-fluorophenyl)-1-piperazinyl]propoxy]-2,3-dihydro-2,2-dimethylbenzofuran (16), 7-[3-(4-phenyl-1-piperazinyl)propoxy]-2,3-dihydro-2,2-dimethylbenzofuran (18) and 7-[3-(4-benzyl-1-piperazinyl)propoxy]-2,3-dihydro-2,2-dimethylbenzofuran (20) have been solved by X-ray structure analysis of single crystals. The crystals of two of them (16 and 18) are isostructural and there are only small differences between their molecular geometries. Greater differences are observed in the crystal structure of the compound 20 due to the presence of a benzyl fragment instead of a phenyl one. The compound 10 (7-(3-t-butylamino-2-hydroxypropoxy)- 2,3-dihydro-2,2-dimethylbenzofuran hydrochloride), screened for basic parameters of rats circulatory system, displayed an effect of decreasing of arterial blood pressure and heart rate