bluuebunny/crossref_metadata_2025_split huggingface dataset:
Microparticles Expressing Myeloperoxidase and Complement C3a and C5a as Markers of Renal Involvement in Antineutrophil Cytoplasmic Antibody–associated Vasculitis
Authors: Antovic Aleksandra , Mobarrez Fariborz , Manojlovic Milena , Soutari Nida , De Porta Baggemar Victoria , Nordin Annica , Bruchfeld Annette , Vojinovic Jelena , Gunnarsson Iva 
Published: August 2019

Objective.To investigate expression of terminal complement components C3a and C5a on circulating myeloperoxidase (MPO)-positive microparticles (MPO+MP) in relation to disease activity and renal involvement in patients with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV).Methods.Forty-six clinically well-characterized patients with AAV and 23 age- and sex-matched healthy controls were included. The concentration of MPO+MP expressing C3a and C5a was analyzed from citrate plasma by flow cytometry. Serum levels of C3a and C5a were determined using commercial ELISA. The assessment of vasculitis disease activity was performed using the Birmingham Vasculitis Activity Score (BVAS). Among patients, 23 had active disease with BVAS ≥ 2 and 14 patients had active renal flares.Results.AAV patients had significantly increased expression of C3a and C5a on MPO+MP compared to controls (both p < 0.0001). When the group of patients with active AAV was divided according to the presence of renal activity, the concentration of MPO+MP expressing C3a and C5a was significantly higher in patients with renal involvement compared to patients with nonrenal disease and controls (p < 0.05 and p < 0.01, respectively). The serum levels of C3a were significantly decreased (p < 0.01) in the renal subgroup, while there were no changes in serum levels of C5a comparing the renal and nonrenal groups. There was significant correlation between the disease activity measured by BVAS and the levels of C3a and C5a expressed on MPO+MP.Conclusion.Determination of C3a and C5a on MPO+MP might be considered as a novel biomarker of renal involvement in patients with AAV and may be of importance in the pathogenetic process.
Calculation of a clinical predictive factors identifying peritoneal disease on a staging laparoscopy in gastric cancers
Authors: Harris Caleb , Ostwal Vikas , Vallathol Dilip Harindran , Dusane Rohit , Mandavkar Sarika , Patkar Shraddha , Ramaswamy Anant , Shrikhande Shailesh V. 
Published: August 2019

Abstract
Introduction: Staging laparoscopy (SL) is the current standard staging workup for loco-advanced gastric cancers (GCs). Materials and Methods: We analyzed the data of all patients with loco-regionally advanced, nonmetastatic GCs, who underwent SL for the evaluation of peritoneal carcinomatosis (PC). Results: Between December 2013 and October 2016, 363 patients underwent SL, of which 75 (20.7%) were found to have PC on SL. Age ≤40 years, CA 19-9 > upper limit of normal, and low serum albumin levels (≤3.5 g/dl) correlated significantly with the presence of PC on SL. There was a statistically significant difference in the median overall survival between patients with radiologically detected PC and SL detected PC (8.67 months vs. 15.3 months;P < 0.0001). Conclusion: SL upstaged disease status in 20.7% of patients. Clinical factors, identified in this study, need further validation in larger prospective cohorts before being used in clinical practice. Patients with radiologically detected PC have lower survival as compared to those with PC on SL.
Langerhans cell histiocytosis: An enigmatic disease
Authors: Jain Anubha , Kumar Sushil , Aggarwal Priyanka , Kumar Mohan , Gupta Vineeta 
Published: August 2019

Abstract
Background: Langerhans cell histiocytosis (LCH) is a poorly understood disease with heterogeneous clinical presentation ranging from unifocal bony involvement to disseminated disease with life-threatening complications. Materials and Methods: The clinical profile, laboratory findings, treatment, and long-term outcome were retrieved from maintained medical records from January 2006 to January 2016 and were retrospectively analyzed. The extent of the disease was classified as per the LCH-III trial of “The Histiocyte Society.” The assessment and categorization of treatment response followed LCH III trial definitions. Results: A total of 28 children with LCH were diagnosed. The age ranged between 5 months and 9 years, with a mean of 3½ years. The M: F ratio was 3:1. Single system, unifocal and multifocal bone diseases were seen in nine (32.1%) and two (7.1%) cases, respectively. Disseminated disease without risk organ involvement was seen in six (21.1%), whereas disseminated disease with risk organ involvement was seen in 11 (39.3%) cases. The most common presentation was bony involvement (19 [67.8%]), out of which 16 (88.8%) had skull involvement. During follow-up, 17 (60.7%) were in complete remission though five (17.8%) of them relapsed, but achieved second remission. Two (7.1%) were lost to follow-up. Six (21.4%) had progressive disease of which four expired and two abandoned treatment. Two (10.7%) refused the initiation of treatment. Conclusion: A better understanding of the disease, early suspicion, and diagnosis can improve the outcome of patients with LCH.
Mutation profile in Indian primary myelofibrosis patients and its clinical implications
Authors: Patil Vinod R. , Chandrakala S. , Mantri Shruti , Patil Rajesh , Wasekar Nilesh , Jijina Farah 
Published: August 2019

Abstract
Background: Primary myelofibrosis (PMF) is a myeloproliferative neoplasm (MPN) characterized by abnormal proliferation of megakaryocytes, bone marrow fibrosis, and extramedullary hematopoiesis. We did mutation profile of 50 patients of PMF and tried to correlate it with initial clinical presentation of these patients. Materials and Methods: All new and follow up patients who were diagnosed as PMF based on WHO 2016 definition of PMF were included. Mutation profile of these patients including JAK2 V617F, JAK2 exon 12, CALR and MPL mutations was done and all clinical, demographic and laboratory details were recorded. Results: Total 50 patients were enrolled out of which 29 were males and 21 were females. Out of these patients, 32 (64%) were JAK2 positive, 13 (26%) were CALR positive, 1 (2%) were MPL positive and 4 (8%) were triple negative. As compared to JAK2+ve patients and triple negative group, CALR positive patients were younger, had lower total leucocyte count, larger spleen size, lower dynamic international prognostic scoring system (DIPSS) score and higher grade of fibrosis of marrow. Conclusion: This study depicts that incidence of JAK2 and CALR mutations in Indian PMF patients is fairly similar to that in rest of the world. CALR positive patients have better clinical parameters at presentation and have better prognosis as compared to JAK2 positive patients.
Correlation of digital mammography and digital breast tomosynthesis features of self-detected breast cancers with human epidermal growth factor receptor type 2/neu status
Authors: Sonthineni Chaitra , Mohindra Namita , Agrawal Vinita , Neyaz Zafar , Jain Neeraj , Mayilvagnan Sabaretnam , Agarwal Gaurav 
Published: August 2019

Abstract
Context: Breast cancer is a heterogeneous disease with several histological subtypes. Its prognosis and management are influenced by human epidermal growth factor receptor type 2 (HER2/neu) expression. Varying grades of HER2/neu overexpression are likely to have different morphological features. Digital breast tomosynthesis (DBT) enhances lesion visibility and hence that it may reveal features closer to histomorphological findings. Aims: The aim of this study is to correlate digital mammography (DM) and DBT findings of self-detected tumors with HER2/neu status, to determine whether differences in imaging features can help predict the degrees of HER2/neu overexpression. Settings and Design: Prospective study conducted in a tertiary care hospital. Methods: For 100 consecutive patients with self-detected lumps, DM and DBT data were reviewed by two radiologists who were blinded to histopathology. Of these, 63 patients with histologically proven breast cancer were recruited and their DM and DBT findings compared and correlated with HER2neu status (scores 0–3+). Statistical Analysis: Pearson's Chi-squared test and Fisher's exact test were used (SPSS version 22.0, IBM). Results: Morphology of lesions at both DM and DBT varied with HER2/neu status (P = 0.04 and 0.015, respectively). HER2-0 tumors mostly presented as masses without microcalcifications (88.8%), while most of HER2-3+ tumors as masses or asymmetries with microcalcifications (61.9%). The presence or absence of calcifications varied significantly with HER2/neu status. Breast imaging-reporting and data system (BI-RADS) scoring varied significantly (P < 0.001) with higher HER2 signal, more frequently associated with BI-RADS 5 score. Conclusion: DM and DBT features vary with the intensity of HER2 immunostaining. Higher BI-RADS scores, microcalcifications, and spiculated margins are frequently associated with HER2/neu 3+ lesions.
Where Heaven and Earth Kiss
Authors: Mayse Ariel Evan 
Published: August 2019

Abstract
Global climate change and environmental disaster are one of the most pressing ethical and existential crises of our day. This articles examines the intricacies of rabbinic tort law (nezikin) with an eye to contemporary questions of pollution and environmental degradation. Taking up three case studies, it outlines the basic thrust of the rabbinic sources and their medieval interpreters, then demonstrating their relevance for contemporary ethical debates and considering their legal and moral implications for our industrialized and globalized economy. These sources demand behavioral changes and a reverence for the world grounded in personal and communal responsibility. The Talmudic sources—read through the lens of aggadah—offer a prescriptive vocabulary for environmental activism from the heart of Jewish legal literature.
Integrative taxonomy resuscitates two species in the Lasioglossum villosulum complex (Kirby, 1802) (Hymenoptera: Apoidea: Halictidae)
Authors: Pauly Alain , Noël Grégoire , Sonet Gontran , Notton David G. , Boevé Jean-Luc 
Published: August 2019

Morphological and allozyme analyses suggested the occurrence of a pseudocryptic species in the Lasioglossum villosulum (Kirby, 1802) species complex (Hymenoptera: Halictidae). We analysed the morphology of more than 1500 specimens and the DNA barcode fragment of the cytochrome c oxidase subunit I (COI) of 102 specimens of this species complex from several Palaearctic countries. Our phylogenetic tree reconstructions, based on maximum likelihood and Bayesian inference revealed one clade corresponding to all specimens morphologically identified as Lasioglossum medinai (Vachal, 1895) and one divergent specimen morphologically identified as Lasioglossum berberum (Benoist, 1941). The other specimens, morphologically identified as L. villosulum, aggregated into at least three other lineages in our phylogenetic trees. The tree-based species delineations methods based on the Generalized Mixed Yule Coalescent (GMYC) model and the Bayesian Poisson Tree Process (bPTP) identified five to ten candidate species within the L. villosulum species complex, with L. medinai and L. berberum consistently recognized as separated from all other candidate species. Diagnostic morphological differences were found among L. medinai, L. berberum and the remaining specimens identified as L. villosulum. No diagnostic morphological differences were found to distinguish the different phylogenetic candidate species or lineages found within L. villosulum and L. medinai. Thus, both genetic and morphological approaches support the existence of L. medinai and L. berberum as distinct species from L. villosulum.
¿Es posible lograr LaLiga más emocionante?
Authors: Pic M. , García-Díaz PR 
Published: August 2019

El objetivo principal de este estudio es estimular el interés público por el campeonato LaLiga. Para ello, se propone un sistema de clasificación alternativo que utiliza variables derivadas de la lógica interna del fútbol y la calidad de los distintos equipos. Aplicando el índice de concordancia de Kendall, las dos clasificaciones se compararon partido a partido, demostrando la viabilidad del nuevo modelo con distintos niveles de competitividad. Las propiedades y limitaciones del modelo fueron comparadas con el modelo empleado actualmente en LaLiga. Proporcionar un proceso que tenga en cuenta la amplia gama de calidad de los equipos que juegan en LaLiga es una alternativa destinada a fomentar la competitividad del campeonato.
The ranking of LaLiga championship for the 2008/09 season was one of the poorest ever in terms of uncertainty. The main aim of this study is to stimulate public interest in the Spanish League championship. To achieve this, an alternative ranking system is proposed using variables derived from soccer’s internal logic and the quality of the various teams. Applying Kendall’s index of concordance, the two rankings were compared play by play demonstrating the viability of the new model, with different levels of competitiveness. The properties and limitations of the model were compared with the one currently used by LaLiga. Providing a process which makes allowances for the wide range of quality of the teams playing in LaLiga is an alternative intended to foment the competitiveness of the championship.
Un enfoque teórico para el uso de las tecnologías de la información y la comunicación en la Educación Física
Authors: Yildiz K. , Güzel Pınar , Zerengök D. 
Published: August 2019

El mundo cambiante de hoy impone nuevos desafíos en todos los aspectos de nuestras vidas. Los cambios más destacados se han observado en la tecnología de la información y las comunicaciones (TIC). Estos cambios impusieron nuevos desafíos para el sistema educativo, las escuelas y especialmente para los docentes. Mantener el ritmo de estos desarrollos ha ganado una mayor popularidad en la cultura digital actual, y en consecuencia el interés académico aumentó significativamente en el uso de tecnologías inteligentes y modernas en el campo de la Educación Física. Hasta ahora, se ha realizado una cantidad razonable de investigación para estudiar la integración de la tecnología en entornos de enseñanza y aprendizaje. Sin embargo, es necesario dedicar más esfuerzo a los reclamos e investigaciones en el ámbito de la Educación Física. Por lo tanto, este documento intenta presentar una breve descripción general sobre el tema, los enfoques, las herramientas y los estudios sobre el uso de la tecnología en el campo de la educación física.
Today’s fast-changing World imposes new challenges in all aspects of our lives. Most prominent changes have been observed in information and communications technology (ICT). These changes imposed new challenges for the education system, schools, and especially for teachers. Keeping up with the pace of these developments has gained an increased popularity in today’s digital culture, and in consequence academic interest increased significantly on using smart and modern technologies in the field of Physical Education. So far a reasonable amount of research has been done to study technology integration in teaching and learning environments. Yet, more effort needs to be spent for the claims and research within the realm of Physical Education. This paper therefore tries to present a short overview on the topic, the approaches, tools and studies about the use of technology in the field of PE.
Efecto de la pasión por la actividad física sobre el agotamiento (físico) en estudiantes atletas
Authors: Mahdavi-Jafari Z. 
Published: August 2019

El objetivo general de este estudio fue investigar el efecto de la pasión por la actividad física en el agotamiento (físico) en estudiantes atletas. El presente estudio fue de tipo de encuesta descriptiva y se basó en modelos de ecuaciones estructurales. La población estadística de esta investigación fue de 350 estudiantes de educación física de cuatro universidades estatales de Teherán. Se seleccionaron de forma aleatoria por grupos y se completaron cuestionarios sobre la pasión y el agotamiento, de los cuales se pudieron utilizar 324 cuestionarios. Los resultados indicaron que la pasión obsesiva con un coeficiente de regresión de 0.23 y un estadístico T de 1.32 no tuvo un efecto significativo en el agotamiento de los estudiantes atletas. Sin embargo, la pasión consistente con un coeficiente de regresión de (-0.66) y un estadístico T de (-2.99) tuvo un efecto negativo significativo en el agotamiento de los estudiantes atletas. Además, el modelo de investigación se ajustó adecuadamente. Por lo tanto, se recomienda que los administradores y ejecutivos universitarios implementen y aceleren la planificación e implementación de acciones para informar a los estudiantes y controlar las consecuencias negativas de estas estructuras.
The general aim of this study was to investigate the effect of passion for physical activity on (physical) burnout in student athletes. The present study was of descriptive survey kind and based on structural equation modeling. The statistical population of this research was 350 physical education students from four state universities in Tehran. They were selected in a cluster-random way, and completed questionnaires on passion and burnout, of which 324 questionnaires were usable. The results indicated that obsessive passion with a regression coefficient of 0.23 and a T-statistics of 1.32 did not have a significant effect on the burnout of student athletes. However, the passion consistent with the regression coefficient (-0.66) and the T-statistics (-2.99) have a significant negative effect on the burnout of student athletes. Furthermore, the research model was adequately adjusted. Therefore, it is recommended that university administrators and executives implement and accelerate the planning and implementation of actions to inform students and control the negative consequences of these structures.
Climate-smart Agricultural Practices in Agro-climatic Zones of Meghalaya: A Social Network Analysis
Authors: Dympep Alethea , Singh R. J. , Hemochandra L. , Singh R. 
Published: August 2019

Aims: To understand the flow of information of Climate Smart Agricultural (CSA) practices among the farmers, the factors that impede this flow and the impact of the social network on adapting CSA practices.
Place and Duration of Study: The study was conducted in hilly state, Meghalaya, India between August 2016 and April 2017.
Methodology: A sample of 120 farmers was selected from agriculturally vulnerable villages to climate change by snowball sampling. The villages were selected from two Agro-climatic zones (ACZs) of the state, Meghalaya. UCINET software was utilised for analysing the Social Network Analysis (SNA) of the community with the performance index used to measure the impact in adopting CSA practices.
Results: The network centralization index obtained in Tropical ACZ was relatively high (0.63) depicting a fragile social network as farmers relied on certain central actors for information and if these actors were to be removed, many farmers would be left isolated. However, in Sub-tropical ACZ, a low index (0.37) was attained implying that farmers had maximum connections in the network. Very low cohesion density measures (<0.05) was obtained in both the ACZs portraying a slow rate of diffusion of information on CSA in the farming community. Further, the homophily index of SNA indicated that the farmers tend to associate more with other farmers having similar socio-economic characteristics. The impact of the social networks in both of the ACZs were highest (68.30%) under low, and (63.30%) under the medium adoption levels of CSA practices in Tropical and Sub-tropical ACZs.
Conclusion: Hence improving access to climate information is an important step to improve the livelihood of people in such variable conditions. With a better understanding of the social factors that influence the flow of knowledge and the adoption of CSA practices in the agricultural sector, researchers and policy makers could be able to identify and reduce barriers to technology diffusion and adoption.
Lifestyle Impact on Glycemic Control in Patients Diagnosed with Type 2 Diabetes
Authors: Barranco-Cuevas Irma Aide , Zavaleta-García Beatriz Hitayatzy , Rodríguez-Chávez María Del Consuelo , García-Galicia Arturo , Gutierrez-Gabriel Itzel , González-López Akihiki Mizuki , Gaytán-Fernández Suemmy 
Published: August 2019

Objective: To determine the association lifestyle and glycemic control of patients with type 2 diabetes.
Study Design: This is a descriptive, cross sectional study.
Place and Duration of Study: This study was conducted in the Family Medicine Unit Number 55 of the Mexican Institute of Social Security in Puebla, Mexico during January to June in 2016.
Methodology: A total of 275 patients in whom the lifestyle and glycemic control were correlated. A questionnaire in which the variables included gender, age, level of education, occupation, marital status, lifestyle, glycemic control and number of years since they were diagnosed with diabetes mellitus type 2 was used. Descriptive statistics and X2 was used.
Results: 275 patients were included who met the inclusion criteria. Their average age was 59.7 years, the female gender prevailed with 64%. A result of X2=3.611 and P=0.05 was obtained; therefore the study was considered statistically significant, since value of P= .05 was considered statistically significant. Conclusion: There is an association between the patient’s lifestyle and glycemic control.
Ecological Survey of Pests and Natural Enemies in the Sour Passion Fruit Progenies
Authors: Silva Rosado Luciana Domiciano , Horst Bruckner Claudio , Sebastião dos Reis Diarly , Silva Assunção Natalia , Da Silva Ézio Marques , Dos Santos Carlos Eduardo Magalhães 
Published: August 2019

Aims: This experiment was to identify the major pests, natural enemies and verify the regarding the incidence of insect pests of progenies of Passiflora edulis to pests.
Study Design: Experimental design was completely randomized blocks with twenty-three progenies and three replicates with four plants per plot.
Place and Duration of Study: Experimental evaluations of the Federal University of Viçosa/Rio Paranaíba University Campus, Rio Paranaíba county, Minas Gerais, Brazil from May to September 2011.
Methodology: The population fluctuation of insects, for characterization of their occurrence and identification of progenies with respect to their degree of resistance.
Results: Among the monitored pests stood out, A. vanillae vanillae, D. juno juno e Dasiops sp. The correlation between the amount of Dione juno juno and the attacked leaf had a higher magnitude of occurrence in relation Agraulis vanillae vanillae.
Conclusion: It was found that there were no differences between the sour passion fruit progenies and resistance to pests, and to verify that ants are important predators of pests of sour passion fruit.
Impact of Oil Price Changes on Selected Macroeconomic Variables in Nigeria
Authors: Florence Ifeyinwa Harbor , Chioma Oleka Dorathy 
Published: August 2019

In this study, the impact of oil price changes on selected variables in Nigeria within the period, 1981-2016 had been evaluated. Adopting the ex-post facto research design with annual time series and using The Autoregressive Distributed Lag (ARDL) model; the results revealed that the change in oil price had a positive and significant impact on government revenue and government expenditure, but had no positive and significant impact on the domestic price level. It is therefore recommended that the monocultural economy should be omitted through well-planned and implementation diversification.