bluuebunny/crossref_metadata_2025_split huggingface dataset:
Validation Study of Histamine Test for the Determination of Histamine in Selected Fish Products
Authors: Shimoji Kazuhiko , Bakke Mikio , Hungerford James M , Mireles DeWitt Christina A , Köse Sevim 
Published: August 2018

Abstract
Background: Since prescribed limits for histamine in fish have been set by various regulatory bodies around the world, the rapid, specific and easy determination of histamine is in high demand. Objective: The enzymatic histamine assay developed by Kikkoman Biochemifa Co. was validated. Methods: Fresh and frozen raw tuna, canned tuna in oil and water, and anchovy fish sauce were used for the validation study under the specific guidelines of the AOAC Research Institute Performance Tested MethodSM (PTM) program. Results: Good linearity (R2 &gt; 0.9997) for histamine standard solutions, recovery rates (90.3–125.2%), and repeatability precisions (RSDr &lt; 10%) were shown for all spiked tested matrixes. The claimed LOQ values, 20 and 10 mg/kg for solid fish and 160 and 80 mg/kg for fish sauce using a 1 and 2 cm optical path length spectrophotometer, respectively, were validated. The cross-reactivity test showed no positive interference of other biogenic amines, except for agmatine and putrescine. Moreover, no inhibition was confirmed among the 12 biogenic amines. Stability data supported the shelf life (42 months at 4°C), lot-to-lot consistency was demonstrated, and the method was shown to be robust. Independent laboratory testing using canned tuna in oil demonstrated that the recovery ranged from 93.5 to 124.7%, and the RSDr at all spike levels was &lt;20%. Conclusions: The simple and rapid enzymatic histamine assay method has been successfully validated. Highlights: This histamine quantitative assay kit was qualified for PTM certification No. 041802.
Reversible Flat to Rippling Phase Transition in Fe Containing Layered Battery Electrode Materials
Authors: Chen Xi , Hwang Sooyeon , Chisnell Robin , Wang Yichao , Wu Fan , Kim Sooran , Lynn Jeffrey W. , Su Dong , Li Xin 
Published: August 2018

AbstractLayered sodium transition metal oxides of NaTMO2 (TM = 3d transition metal) show unique capability to mix different compositions of Fe to the TM layer, a phenomenon that does not exist in LiTMO2. Here, a novel spontaneous TM layer rippling in the sodium ion battery cathode materials is reported, revealed by in situ X‐ray diffraction, Cs‐corrected scanning transmission electron microscopy, and density functional theory simulation, where the softening and distortion of FeO6 octahedra collectively drives the flat TM planes into rippled ones with inhomogeneous interlayer distance at high voltage. In such a rippling phase, charge and discharge of Na ions take different evolution pathways, resulting in an unusual hysteresis voltage loop. Importantly, upon discharge beyond a certain Na composition, the rippling TM layer will go back to flat, giving the reversibility of such structural evolution in the following cycles.
3D Spatiotemporal Mechanical Microenvironment: A Hydrogel‐Based Platform for Guiding Stem Cell Fate
Authors: Ma Yufei , Lin Min , Huang Guoyou , Li Yuhui , Wang Shuqi , Bai Guiqin , Lu Tian Jian , Xu Feng 
Published: August 2018

AbstractStem cells hold great promise for widespread biomedical applications, for which stem cell fate needs to be well tailored. Besides biochemical cues, accumulating evidence has demonstrated that spatiotemporal biophysical cues (especially mechanical cues) imposed by cell microenvironments also critically impact on the stem cell fate. As such, various biomaterials, especially hydrogels due to their tunable physicochemical properties and advanced fabrication approaches, are developed to spatiotemporally manipulate biophysical cues in vitro so as to recapitulate the 3D mechanical microenvironment where stem cells reside in vivo. Here, the main mechanical cues that stem cells experience in their native microenvironment are summarized. Then, recent advances in the design of hydrogel materials with spatiotemporally tunable mechanical properties for engineering 3D the spatiotemporal mechanical microenvironment of stem cells are highlighted. These in vitro engineered spatiotemporal mechanical microenvironments are crucial for guiding stem cell fate and their potential biomedical applications are subsequently discussed. Finally, the challenges and future perspectives are presented.
Overcoming the Blood–Brain Barrier: The Role of Nanomaterials in Treating Neurological Diseases
Authors: Furtado Denzil , Björnmalm Mattias , Ayton Scott , Bush Ashley I. , Kempe Kristian , Caruso Frank 
Published: August 2018

AbstractTherapies directed toward the central nervous system remain difficult to translate into improved clinical outcomes. This is largely due to the blood–brain barrier (BBB), arguably the most tightly regulated interface in the human body, which routinely excludes most therapeutics. Advances in the engineering of nanomaterials and their application in biomedicine (i.e., nanomedicine) are enabling new strategies that have the potential to help improve our understanding and treatment of neurological diseases. Herein, the various mechanisms by which therapeutics can be delivered to the brain are examined and key challenges facing translation of this research from benchtop to bedside are highlighted. Following a contextual overview of the BBB anatomy and physiology in both healthy and diseased states, relevant therapeutic strategies for bypassing and crossing the BBB are discussed. The focus here is especially on nanomaterial‐based drug delivery systems and the potential of these to overcome the biological challenges imposed by the BBB. Finally, disease‐targeting strategies and clearance mechanisms are explored. The objective is to provide the diverse range of researchers active in the field (e.g., material scientists, chemists, engineers, neuroscientists, and clinicians) with an easily accessible guide to the key opportunities and challenges currently facing the nanomaterial‐mediated treatment of neurological diseases.
Flexible Electronics Based on Micro/Nanostructured Paper
Authors: Zhang Yan , Zhang Lina , Cui Kang , Ge Shenguang , Cheng Xin , Yan Mei , Yu Jinghua , Liu Hong 
Published: August 2018

AbstractOver the past several years, a new surge of interest in paper electronics has arisen due to the numerous merits of simple micro/nanostructured substrates. Herein, the latest advances and principal issues in the design and fabrication of paper‐based flexible electronics are highlighted. Following an introduction of the fascinating properties of paper matrixes, the construction of paper substrates from diverse functional materials for flexible electronics and their underlying principles are described. Then, notable progress related to the development of versatile electronic devices is discussed. Finally, future opportunities and the remaining challenges are examined. It is envisioned that more design concepts, working principles, and advanced papermaking techniques will be developed in the near future for the advanced functionalization of paper, paving the way for the mass production and commercial applications of flexible paper‐based electronic devices.
Binary Cooperative Prodrug Nanoparticles Improve Immunotherapy by Synergistically Modulating Immune Tumor Microenvironment
Authors: Feng Bing , Zhou Fangyuan , Hou Bo , Wang Dangge , Wang Tingting , Fu Yuanlei , Ma Yuting , Yu Haijun , Li Yaping 
Published: August 2018

AbstractCheckpoint blockade immunotherapy is promising for clinical treatment of various malignant tumors. However, checkpoint blockade immunotherapy suffers from a low response rate due to insufficient tumor immunogenicity and the immunosuppressive tumor microenvironment (ITM). In this study, a tumor‐microenvironment‐activatable binary cooperative prodrug nanoparticle (BCPN) is rationally designed to improve immunotherapy by synergistically modulating the immune tumor microenvironment. BCPN is purely constructed from a tumor acidity and reduction dual‐responsive oxaliplatin (OXA) prodrug for triggering immunogenic cell death (ICD) and eliciting antitumor immunity, and a reduction‐activatable homodimer of NLG919 for inactivating indoleamine 2,3‐dioxygenase 1, which is a key regulator for ITM. Upon tumor‐acidity‐triggered cleavage of the poly(ethylene glycol) shell, PN shows negative to positive charge switch for enhanced tumor accumulation and deep penetration. OXA and NLG919 are then activated in the tumor cells via glutathione‐mediated reduction. It is demonstrate that activated OXA promotes intratumoral accumulation of cytotoxic T lymphocytes by triggering ICD of cancer cells. Meanwhile, NLG919 downregulates IDO‐1‐mediated immunosuppression and suppresses regulatory T cells. Most importantly, PN shows much higher efficiency than free OXA or the combination of free OXA and NLG919 to regress tumor growth and prevent metastasis of mouse models of both breast and colorectal cancer.
In vivo characterization of white matter pathology in premanifest huntington's disease
Authors: Zhang Jiaying , Gregory Sarah , Scahill Rachael I. , Durr Alexandra , Thomas David L. , Lehericy Stéphane , Rees Geraint , Tabrizi Sarah J. , Zhang Hui ,   the TrackOn‐HD investigators
Published: August 2018

ObjectiveHuntington's disease (HD) is a monogenic, fully penetrant neurodegenerative disorder, providing an ideal model for understanding brain changes occurring in the years prior to disease onset. Diffusion tensor imaging (DTI) studies show widespread white matter disorganization in the early premanifest stages (pre‐HD). However, although DTI has proved informative, it provides only limited information about underlying changes in tissue properties. Neurite orientation dispersion and density imaging (NODDI) is a novel magnetic resonance imaging (MRI) technique for characterizing axonal pathology more specifically, providing metrics that separately quantify axonal density and axonal organization. Here, we provide the first in vivo characterization of white matter pathology in pre‐HD using NODDI.MethodsDiffusion‐weighted MRI data that support DTI and NODDI were acquired from 38 pre‐HD and 45 control participants. Using whole‐brain and region‐of‐interest analyses, NODDI metrics were compared between groups and correlated with clinical scores of disease progression. Whole‐brain changes in DTI metrics were also examined.ResultsThe pre‐HD group displayed widespread reductions in axonal density compared with control participants; this correlated with measures of clinical disease progression in the body and genu of the corpus callosum. There was also evidence in the pre‐HD group of increased coherence of axonal packing in the white matter surrounding the basal ganglia.InterpretationOur findings suggest that reduced axonal density is one of the major factors underlying white matter pathology in pre‐HD, coupled with altered local organization in areas surrounding the basal ganglia. NODDI metrics show promise in providing more specific information about the biological processes underlying HD and neurodegeneration per se. Ann Neurol 2018;84:497–504
Detektieren mit Nanopipetten im eingeschränkten Raum: von einzelnen Molekülen über Nanopartikel hin zu der Zelle
Authors: Yu Ru‐Jia , Ying Yi‐Lun , Gao Rui , Long Yi‐Tao 
Published: August 2018

AbstractNanopipetten bieten eine geeignete Methode, um elektrochemische, optische und massenspektrometrische Messungen auf der Nanoebene durchzuführen. Durch ihre Anwendung konnten die Dynamiken und Eigenschaften einzelner Moleküle und Partikel aufgedeckt werden. Darüber hinaus wurden neue, auf Nanopipetten basierende Detektionsmechanismen eingesetzt, die detaillierte Informationen auf Einzelzellebene mit hoher zeitlicher‐ und räumlicher Auflösung liefern konnten. Dieser Aufsatz behandelt die Herstellung und Charakterisierung von Nanopipetten. Zusammenfassend beschreiben wir ihre vielseitigen Anwendungsbereiche für die Analyse von Einzelproben und geben einen Einblick in fortgeschrittene Anwendungen für Nanopipetten.
How Water Accelerates Bivalent Ion Diffusion at the Electrolyte/Electrode Interface
Authors: Wang Fei , Sun Wei , Shadike Zulipiya , Hu Enyuan , Ji Xiao , Gao Tao , Yang Xiao‐Qing , Xu Kang , Wang Chunsheng 
Published: August 2018

AbstractThe effect of H2O in electrolytes and in electrode lattices on the thermodynamics and kinetics of reversible multivalent‐ion intercalation chemistry based on a model platform of layered VOPO4 has been investigated. The presence of H2O at the electrolyte/electrode interface plays a key role in assisting Zn2+ diffusion from electrolyte to the surface, while H2O in the lattice structure alters the working potential. More importantly, a dynamic equilibrium between bulk electrode and electrolyte is eventually reached for H2O transport during the charge/discharge cycles, with the water activity serving as the key parameter determining the direction of water movement and the cycling stability.
Hochkonversion von Reduktionsmitteln
Authors: Syroeshkin Mikhail A. , Kuriakose Febin , Saverina Evgeniya A. , Timofeeva Vladislava A. , Egorov Mikhail P. , Alabugin Igor V. 
Published: August 2018

AbstractDie zahlreichen Anwendungen der Photonen‐Hochkonversion – d. h. der Umwandlung von Photonen mit niedriger Energie in Photonen mit hoher Energie – werfen die Frage nach der Möglichkeit einer “Elektronen‐Hochkonversion” auf. In diesem Aufsatz zeigen wir, wie das Reduktionspotential durch Nutzung der Gibbs‐Energie exergonischer chemischer Reaktionen gesteigert werden kann. Die Elektronen(Reduktionsmittel)‐Hochkonversion kann dabei bis zu 20–25 kcal mol−1 zusätzliches Redoxpotential erzeugen und somit unter milden Bedingungen starke Reduktionsmittel bereitstellen. Wir werden die beiden gebräuchlichen Arten Elektronen‐hochkonvertierender Systeme vorstellen: dissoziativ (basierend auf unimolekularen Fragmentierungen) und assoziativ (basierend auf der bimolekularen Bildung von Drei‐Elektronen‐Bindungen). Der mögliche Nutzen der Hochkonversion von Reduktionsmitteln umfasst Redoxkettenreaktionen in elektrokatalytischen Prozessen, Photoredoxkaskaden, das Design von Peroxid‐basierten Medikamenten, die Glühwürmchen‐Lumineszenz sowie die reduktive Reparatur von DNA‐Photoschäden.
Air‐Stable Lithium Spheres Produced by Electrochemical Plating
Authors: Yang Tingting , Jia Peng , Liu Qiunan , Zhang Liqiang , Du Congcong , Chen Jingzhao , Ye Hongjun , Li Xiaomei , Li Yanshuai , Shen Tongde , Tang Yongfu , Huang Jianyu 
Published: August 2018

AbstractLithium metal is an ideal anode for next‐generation lithium batteries owing to its very high theoretical specific capacity of 3860 mAh g−1but very reactive upon exposure to ambient air, rendering it difficult to handle and transport. Air‐stable lithium spheres (ASLSs) were produced by electrochemical plating under CO2atmosphere inside an advanced aberration‐corrected environmental transmission electron microscope. The ASLSs exhibit a core–shell structure with a Li core and a Li2CO3shell. In ambient air, the ASLSs do not react with moisture and maintain their core–shell structures. Furthermore, the ASLSs can be used as anodes in lithium‐ion batteries, and they exhibit similar electrochemical behavior to metallic Li, indicating that the surface Li2CO3layer is a good Li+ion conductor. The air stability of the ASLSs is attributed to the surface Li2CO3layer, which is barely soluble in water and does not react with oxygen and nitrogen in air at room temperature, thus passivating the Li core.
Photoredox Catalytic Organic Transformations using Heterogeneous Carbon Nitrides
Authors: Savateev Aleksandr , Ghosh Indrajit , König Burkhard , Antonietti Markus 
Published: August 2018

AbstractPhotoredox catalysis comprising homogeneous transition‐metal‐based systems, organic dyes, and semiconductors, has become a universal tool to catalyze a wide variety of chemical reactions with high selectivity and under mild conditions using visible light irradiation. This Minireview summarizes recent progress in photoredox catalysis mediated by heterogeneous carbon nitride materials such as mesoporous graphitic carbon nitride (mpg‐CN), polymeric carbon nitride, and potassium poly(heptazine imides) (K‐PHI). Because of the high thermal, chemical, and photostability of these materials, as well as favorable conduction and valence band positions, carbon nitrides expand the reaction range of photocatalysis to many novel reactions, such as photocatalytic activation of elemental sulfur to furnish a convenient chemical route to organosulfur compounds.
Direct Conversion of Syngas into Methyl Acetate, Ethanol, and Ethylene by Relay Catalysis via the Intermediate Dimethyl Ether
Authors: Zhou Wei , Kang Jincan , Cheng Kang , He Shun , Shi Jiaqing , Zhou Cheng , Zhang Qinghong , Chen Junchao , Peng Luming , Chen Mingshu , Wang Ye 
Published: August 2018

AbstractSelective conversion of syngas (CO/H2) into C2+oxygenates is a highly attractive but challenging target. Herein, we report the direct conversion of syngas into methyl acetate (MA) by relay catalysis. MA can be formed at a lower temperature (ca. 473 K) using Cu‐Zn‐Al oxide/H‐ZSM‐5 and zeolite mordenite (H‐MOR) catalysts separated by quartz wool (denoted as Cu‐Zn‐Al/H‐ZSM‐5|H‐MOR) and also at higher temperatures (603–643 K) without significant deactivation using spinel‐structured ZnAl2O4|H‐MOR. The selectivity of MA and acetic acid (AA) reaches 87 % at a CO conversion of 11 % at 643 K. Dimethyl ether (DME) is the key intermediate and the carbonylation of DME results in MA with high selectivity. We found that the relay catalysis using ZnAl2O4|H‐MOR|ZnAl2O4gives ethanol as the major product, while ethylene is formed with a layer‐by‐layer ZnAl2O4|H‐MOR|ZnAl2O4|H‐MOR combination. Close proximity between ZnAl2O4and H‐MOR increases ethylene selectivity to 65 %.
Reprogramming Human Siderocalin To Neutralize Petrobactin, the Essential Iron Scavenger of Anthrax Bacillus
Authors: Dauner Martin , Eichinger Andreas , Lücking Genia , Scherer Siegfried , Skerra Arne 
Published: August 2018

AbstractBacillus anthracis owes its pronounced virulence—apart from specific toxins—to a twofold import mechanism for FeIII ions. This pathogenic bacterium secretes the siderophores bacillibactin (BB) and petrobactin (PB), of which only BB is neutralized by human siderocalin, an abundant lipocalin in plasma. We describe its reshaping via combinatorial protein design to bind PB⋅FeIII instead of BB⋅FeIII, and with even higher affinity (KD≈20 pm). X‐ray crystallographic analysis of the resulting “petrocalin” in complex with PB⋅GaIII reveals a positively charged ligand pocket while the extended butterfly‐like conformation of the bound PB provides a rationale for the missing recognition by the natural siderocalin. In microbiological studies, a combination of petrocalin and siderocalin effectively suppressed the growth of a BB+/PB+ strain of Bacillus cereus under iron‐limiting culture conditions. Thus, our reprogrammed lipocalin may offer novel treatment options for devastating infections caused by B. anthracis.
Guideline Implementation: Team Communication
Authors: Link Terri 
Published: August 2018

AbstractThe perioperative environment is fast paced and complex. Competing responsibilities, noise and distractions, and reluctance of team members to speak up when they are aware of a potential patient safety issue are all barriers to effective communication in the perioperative setting. Communication breakdowns among health care providers can lead to medical errors and patient harm. Accurate and complete communication about the patient and the patient's care can contribute to improved efficiency, better patient outcomes, and fewer adverse events. The new AORN “Guideline for team communication” provides guidance on using standardized processes and tools to improve the quality of team communication. The key points address hand overs between phases of perioperative care; a briefing to share the surgical plan; a time out to verify the correct patient, procedure, site, and side; and a debriefing to discuss what was learned and how to improve. Perioperative RNs should review the complete guideline for additional information and for guidance when writing and updating policies and procedures.
Perioperative Care of the Patient With Acoustic Neuroma
Authors: Oster Kristen A. 
Published: August 2018

AbstractAcoustic neuromas, also known as vestibular schwannomas, are slow‐growing, benign tumors that develop on the eighth cranial nerve. Common signs and symptoms of an acoustic neuroma include hearing loss and balance disturbances. A physical examination, a hearing evaluation, and diagnostic imaging assist in the diagnosis of an acoustic neuroma. Patients with a confirmed tumor have three treatment options: observation, stereotactic radiosurgery, and surgical removal. Complications include cerebrospinal fluid leakage, damage to ancillary brain structures, facial nerve damage, and bleeding or vascular injury. This article focuses on the surgical removal of an acoustic neuroma and the role of the perioperative nurse in the perioperative care of the patient.
Using systematic conservation planning to establish management priorities for freshwater salmon conservation, Matanuska‐Susitna Basin, AK, USA
Authors: Witt Andrew , Hammill Edd 
Published: August 2018

AbstractThe Alaskan Matanuska‐Susitna Basin (MSB) provides habitat for all five Pacific salmon species, and their large seasonal spawning runs are important both ecologically and economically. However, the encroachment of human development through urbanization and extractive industries poses a serious risk to salmon habitat in the MSB.Using systematic conservation planning techniques, different methods of incorporating anthropogenic risks were assessed to determine how to conserve salmon habitat in the area cost‐effectively.The consequences of four distinct conservation scenarios were quantified: no consideration either of urbanization or extractive industries (‘Risk ignored’ scenario); accounting for the risk of urbanization, and avoiding conservation in all areas rich in fossil fuels (‘Urbanization accounted, all extraction avoided’ scenario); accounting for urbanization and oil and gas development, but avoiding conservation in coal‐rich areas (‘Urbanization accounted, coal areas avoided’ scenario); and accounting for all anthropogenic risks to habitat, and allowing conservation in oil, gas, or coal‐rich areas (‘All risks accounted’ scenario). To compare conservation success and resilience, the impacts of these risks were estimated using Monte Carlo simulations. The final cost of each solution was then divided by the number of conservation targets met to determine a return on investment.Results from scenarios that avoided all extractive activities, or only coal, suggest that conservation targets cannot be met simply by avoiding areas rich in fossil fuels, and these scenarios resulted in lower returns on investment than those in which risks from extraction were incorporated into the solution.By developing a method for setting priorities that are economically based, this study provides a method for local managers and conservation groups to identify conservation opportunities in MSB river basins.