bluuebunny/crossref_metadata_2025_split huggingface dataset:
FCGR2A/FCGR3A Gene Polymorphisms and Clinical Variables as Predictors of Response to Tocilizumab and Rituximab in Patients With Rheumatoid Arthritis
Authors: Jiménez Morales Alberto , Maldonado‐Montoro Mar , Martínez de la Plata Juan Enrique , Pérez Ramírez Cristina , Daddaoua Abdelali , Alarcón Payer Carolina , Expósito Ruiz Manuela , García Collado Carlos 
Published: November 2018

AbstractWe evaluated the influence of clinical, biochemical, and genetic factors on response in 142 patients diagnosed with rheumatoid arthritis, of whom 87 patients were treated with tocilizumab (61.26%) and 55 patients were treated with rituximab (38.7%;) according to the variables European League Against Rheumatism (EULAR) response, remission, low disease activity, and improvement in Disease Activity Score, 28 joints (DAS28) at 6, 12, and 18 months. A retrospective prospective cohort study was conducted. Patients carrying the FCGR3A rs396991‐TT genotype treated with tocilizumab showed higher EULAR response (OR, 5.075; 95%CI, 1.20–21.33; P = .027) at 12 months, those who were naive for biological disease‐modifying antirheumatic drugs (bDMARDs) at the beginning of treatment showed satisfactory EULAR response, higher remission, and greater improvement in DAS28 at 6 months. Younger age at start of tocilizumab treatment was associated with satisfactory EULAR response at 18 months and greater remission at 6 and 18 months. Subcutaneous tocilizumab administration was associated with higher remission at 6 months and improved low disease activity rate at 12 months. In patients treated with rituximab, carriers of the FCGR2A rs1801274‐TT genotype had higher EULAR response at 6 months (OR, 4.861; 95%CI, 1.11–21.12; P = .035), 12 months (OR, 4.667; p = 0.066, 95%CI, 0.90–24.12; P = .066), and 18 months (OR, 2.487; 95%CI, 0.35–17.31; P = .357), higher remission (OR: 10.625; p = 0.044, CI95%: 1.07, 105.47) at 6 months, and greater improvement in DAS28 at 12 months (B = 0.782; 95%CI, −0.15 to 1.71; P = .098) and 18 months (B = 1.414; 95%CI, 0.19–2.63; P = .025). The FCGR3A rs396991‐G allele was associated with improved low disease activity rate (OR, 4.904; 95%CI, 0.84–28.48; P = .077) and greater improvement in DAS28 (B = −1.083; 95%CI, −1.98 to −0.18; P = .021) at 18 months. Patients with a lower number of previous biological therapies had higher remission at 12 months. We suggest that the FCGR3A rs396991‐TT genotype, higher baseline value of DAS28, subcutaneous tocilizumab administration, younger age at the beginning of treatment, and being bDMARD naive are associated with better response to tocilizumab. In patients treated with rituximab, we found better response in those patients with the FCGR2A rs1801274‐TT genotype, the FCGR3A rs396991‐G allele, and lower number of previous biological therapies.
Full‐thickness rotator cuff tear in rat results in distinct temporal expression of multiple proteases in tendon, muscle, and cartilage
Authors: Treviño Elda A. , McFaline‐Figueroa Jennifer , Guldberg Robert E. , Platt Manu O. , Temenoff Johnna S. 
Published: November 2018

ABSTRACTThe etiology of joint tissue degeneration following rotator cuff tear remains unclear. Thus, the purpose of this study was to understand the timeline of protease activity in the soft tissues of the shoulder (tendon, muscle, and cartilage) that may lead to down‐stream degeneration following rotator cuff tear. A well‐established rat model involving suprascapular nerve denervation and supraspinatus/infraspinatus tendon transection was employed. Histological staining and/or micro‐computed tomography (µCT) were used to observe structural damage in the supraspinatus tendon and muscle, humeral head cartilage, and subchondral bone. Multiplex gelatin zymography was utilized to assess protease activity in the supraspinatus tendon and muscle, and humeral head cartilage. Zymography analysis demonstrated that cathepsins were upregulated in the first week in all tissues, while MMP‐2 maintained prolonged activity in supraspinatus tendon between 1 and 3 weeks and increased only at 3 weeks in supraspinatus muscle. In supraspinatus tendon, increased cathepsin L and MMP‐2 activity in the first week was concurrent with matrix disorganization and infiltration of inflammatory cells. In contrast, significant upregulation of cathepsin L and K activity in supraspinatus muscle and humeral head cartilage did not correspond to any visible tissue damage at 1 week. However, focal defects developed in half of all animals’ humeral head cartilage by 12 weeks (volume: 0.12 ± 0.09 mm3). This work provides a more comprehensive understanding of biochemical changes to joint tissue over time following rotator cuff tear. Overall, this provides insight into potential therapeutic targets and will better inform ideal intervention times and treatments for each tissue. © 2018 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 37:490–502, 2019.
Dietary nutrient levels alter the metabolism of arginine family amino acids in the conceptus of Huanjiang mini‐pigs
Authors: Duan Yehui , Zhao Yue , Zhu Qian , Cai Qiaoli , Li Huawei , Yin Yulong , Wang Zhanbin , Kong Xiangfeng 
Published: November 2018

AbstractBACKGROUNDThe arginine family amino acids (AFAAs) exert important roles in the metabolism, growth and development of the conceptus. However, to date, few studies have investigated the effects of maternal nutrient levels on the concentrations and metabolism of AFAAs in the conceptus.RESULTSCompared to low nutrient diets, high nutrient diets increased (P < 0.05) the concentrations of citrulline and proline (Pro) in plasma; the concentrations of arginine, glutamine, Pro and ornithine (Orn) in the amniotic fluid; and the concentrations of all detected AFAAs in the allantoic fluid, which were most pronounced on day 45 of pregnancy. High nutrient diets upregulated (P < 0.05) mRNA expression of arginase I (Arg I), Pro oxidase and spermidine synthetase (SRM) in the fetal placenta, as well as Arg II, SRM and spermine synthetase (SMS) expression in the fetal liver (most pronounced on day 45 of pregnancy). The same effect was observed for mRNA expression of NO synthase and Orn aminotransferase (OAT), mainly on day 110 of pregnancy, and for mRNA expression of Arg I, Arg II, OAT, Orn decarboxylase and SMS throughout pregnancy. High nutrient diets upregulated (P < 0.05) mRNA expression of Y+ L‐type amino acid transporter (LAT) and cationic amino acid transporter 1 (CAT1) in the fetal jejunum throughout pregnancy. Dietary treatments did not affect (P > 0.05) mRNA expression of Y+ LAT1, sodium‐coupled neutral amino acid transporter 2 (SNAT2) and CAT1 in the fetal placenta, skeletal muscle and colon.CONCLUSIONHigh nutrient diets increased the concentration and transport of AFAAs in the mothers and conceptus, which likely improves growth and development of the conceptus. © 2018 Society of Chemical Industry
Self‐Assembly of Polymer‐Coated Plasmonic Nanocrystals: From Synthetic Approaches to Practical Applications
Authors: Lu Derong , Zhou Jiajing , Chen Yonghao , Ma Jielin , Duan Hongwei 
Published: November 2018

AbstractSelf‐assembly of plasmonic nanocrystals (PNCs) and polymers provides access to a variety of functionalized metallic‐polymer building blocks and higher‐order hybrid plasmonic assemblies, and thus is of considerable fundamental and practical interest. The hybrid assemblies often not only inherit individual characteristics of polymers and PNCs but also exhibit distinct photophysical and catalytic properties compared to that of a single PNC building block. The tailorable plasmonic coupling between PNCs within assemblies enables the precise control over localized surface plasmon resonance, which subsequently affords a series of light‐driven or photo‐activated applications, such as surface‐enhanced Raman scattering detection, photoacoustic imaging, photothermal therapy, and photodynamic therapy. In this review, the synthetic strategies of a library of PNC‐polymer hybrid building blocks and corresponding assemblies are summarized along with the mechanisms of polymer‐assisted self‐assembly of PNCs and the concepts for bridging the intrinsic properties of PNC‐polymer assemblies to widespread practical applications.
On the symmetry of scattering matrix in waveguide circuits
Authors: Gentili Gian Guido , Pelosi Giuseppe , Piccioli Francesco , Selleri Stefano 
Published: November 2018

AbstractThe well‐known symmetry property of the scattering matrix relative to propagating modes becomes tricky in the case of arbitrary polarization or arbitrary complex modal functions, as in the case of waveguide polarizers and ortho‐mode transducers. A straightforward transformation between different modal bases for the guided waves leads to a loss of symmetry. Only by gaining a deeper insight on the properties of the scattering matrices and with separate transformations for the incident and reflected waves is symmetry recovered.
Inset‐fed rectangular MICROSTRIP patch antenna bandwidth enhancement
Authors: Mbinack Clément , Bodo Bertrand , Eyébé Fouda Jean‐Sire A. , Tonye Emmanuel 
Published: November 2018

AbstractBandwidth enhancement of the traditional inset‐fed rectangular microstrip patch antenna is numerically analyzed using degraded ground plane technique. Input impedance calculation based on the electromagnetic theory in traveling‐wave in conjunction with field distribution in quasi‐TEM mode approximation is carried out. Radiated electric field properties are performed using Ampere's law of the magneto‐static. Some antenna performances such as −10 dB return loss bandwidth of 36.7%, beam‐width of about 94°, and stable gain of 3.4 dB have been achieved.
Wide‐bandwidth thru‐reflect‐line calibration for empty substrate‐integrated coaxial line with grounded coplanar transitions
Authors: Fernandez Marcos D. , Ballesteros José A. , Martinez Juan A. , de Dios Juan Jose , Belenguer Angel 
Published: November 2018

AbstractEmpty coaxial structures built with printed circuit boards have low radiation, low losses, high quality factor and non‐dispersive features. The full integration of empty substrate‐integrated coaxial line (ESICL) in a planar substrate is nowadays a fact thanks to a grounded coplanar transition. To properly characterize and measure this new ESICL family of devices, a low cost and easy to manufacture thru‐reflect‐line calibration kit is proposed to de‐embed not only the connectors and feeding lines, but also the ESICL transitions.
Impact of Facilitated Behavior Change Strategies on Food Intake Monitoring and Body Weight Measurements in Acute Care: Case Examples From the More‐2‐Eat Study
Authors: Laur Celia , Butterworth Donna , Nasser Roseann , Bell Jack , Marcell Chelsa , Murphy Joseph , Valaitis Renata , Bernier Paule , Ray Sumantra , Keller Heather 
Published: November 2018

AbstractBackground: Assessing and monitoring food intake and body weight of all hospital patients is considered part of “best practice” nutrition care. This study presents case examples describing the impact of behavior change strategies on embedding these 2 monitoring processes in hospitals.Methods: Four hospital medical units that participated in the More‐2‐Eat implementation study to improve nutrition care focused on improving food intake and/or weight monitoring practices. The percentage of admitted patients who received these care practices were tracked through chart audits over 18 months. Implementation progress and behavior change strategies were documented through interviews, focus groups, scorecards, and monthly telephone calls. Case examples are explored using mixed methods.Results: Of the 4 units, 3 implemented food intake monitoring. One provided food service workers the opportunity to record food intake, with low intake discussed by an interdisciplinary team during bedside rounds (increased from 0% to 97%). Another went from 0% to 61% of patients monitored by introducing a new form (“environmental restructuring”) reminding staff to ask patients about low intake. A third unit increased motivation to improve documentation of low intake and improved from 3% to 95%. Two units focused on regularity of body weight measurement. One unit encouraged a team approach and introduced 2 weigh days/week (improved from 14% to 63%), while another increased opportunity by having all patients weighed on Saturdays (improved from 11% to 49%).Conclusion: Difficult‐to‐change nutrition care practices can be implemented using diverse and ongoing behavior change strategies, staff input, a champion, and an interdisciplinary team.
A priori and a posteriori error estimates of finite‐element approximations for elliptic optimal control problem with measure data
Authors: Shakya Pratibha , Sinha Rajen Kumar 
Published: November 2018

SummaryWe analyze both a priori and a posteriori error analysis of finite‐element method for elliptic optimal control problems with measure data in a bounded convex domain in
(d = 2or3). The solution of the state equation of such type of problems exhibits low regularity due to the presence of measure data, which introduces some difficulties for both theory and numerics of the finite‐element method. We first prove the existence, uniqueness, and regularity of the solution to the optimal control problem. To discretize the control problem, we use continuous piecewise linear elements for the approximations of the state and co‐state variables, whereas piecewise constant functions are used for the control variable. We derive a priori error estimates of order
for the state, co‐state, and control variables in the L2‐norm. Further, global a posteriori upper bounds for the state, co‐state, and control variables in the L2‐norm are established. Moreover, local lower bounds for the errors in the state and co‐state variables and a global lower bound for the error in the control variable are obtained in the case of two space dimensions (d = 2). Numerical experiments are provided, which support our theoretical results.
Synthesis and kinetic study on the thermal degradation of triblock copolymer of polycaprolactone‐poly (glycidyl nitrate)‐polycaprolactone (PCL‐PGN‐PCL) as an energetic binder
Authors: Abrishami Fatemeh , Zohari Narges , Zeynali Vida 
Published: November 2018

In this study, an energetic binder is synthesized via ring opening copolymerization of ε‐caprolactone with poly (glycidyl nitrate) (PGN) of low molecular weight (Mn = 1350 g mol−1) as a macroinitiator to form triblock copolymer polycaprolactone‐PGN‐polycaprolactone (PCL‐PGN‐PCL) (Mn = 4128 g mol−1). The effects of catalyst type and its concentration, reaction time, and solvent are investigated in this polymerization reaction. The resulting triblock copolymer is characterized by Fourier transform infrared spectroscopy (FT‐IR), nuclear magnetic resonance spectroscopy (NMR), gel permeation chromatography (GPC), differential scanning calorimetry (DSC), and thermal gravimetric analysis (TGA). The DSC result shows that the glass transition temperature of triblock copolymer (Tg = −50°C) is lower than PGN (Tg = −35°C). Also, the decomposition kinetics of this energetic binder is studied by DSC, TGA, and its derivative (DTG). An advanced isoconversional method is applied for kinetic analysis. Activation energy is calculated by Flynn‐Wall‐Ozawa (FWO) and Kissinger methods. The resulting activation energy from Kissinger method for the first and the second steps are 42.98 and 74.56 kJ mol−1, respectively. Also, it is found from FWO results that the activation energy for the copolymer increases with degradation degree (α).
The human circadian clock from health to economics
Authors: Koritala Bala S. C. , Çakmaklı Selim 
Published: November 2018

AbstractIn the course of evolution, health is prioritized for human well‐being and economies. Epidemiological and experimental studies suggest that modern life habits, including eating habits, and living and working conditions, can deteriorate health through circadian misalignment. This has been most commonly observed with urban societies and working classes of non‐standard working schedules (NSWSs), such as shift work, night work, and overtime work. Poor health conditions with NSWSs generate economic burden for the modern society. Therefore, we attempt to provide a systematic approach to understanding the relations among the circadian clock, health, and economics. To understand these connections, we review the mechanisms of the human circadian clock and how modern living conditions can misalign the circadian system and associated health consequences. We also emphasize the importance of health for the modern economy and the economic costs of health disorders associated with circadian disruption and NSWSs.
The Portuguese version of the Personality Inventory for the DSM‐5 in a community and a clinical sample
Authors: Pires Rute , Sousa Ferreira Ana , Gonçalves Bruno , Henriques‐Calado Joana , Paulino Marco 
Published: November 2018

AbstractThe Personality Inventory for DSM‐5 (PID‐5) measures the maladaptive traits of the model for personality and its disorders, as proposed in section III of the DSM‐5. The current study aimed to examine whether the Portuguese PID‐5 distinguished non‐clinical participants (N = 1223, Mage = 36.73, standard deviation = 15.72) from clinical participants (N = 202, Mage = 43.82, standard deviation = 11.33) with respect to dysfunctional personality traits and to explore the PID‐5 factor structure in both samples. The PID‐5 scale medians were higher in the clinical sample than in the community sample. All analyses were statistically significant (p ≤ 0.001) with medium size effects. In the community sample, a five‐factor structure emerged, and the factors resembled the PID‐5 domains. However, in the clinical sample, a four‐factor structure was retained, in which the Psychoticism domain did not clearly emerge. The composition of the clinical sample along with its small size may account for these unexpected results. Overall, the results provide evidence of the PID‐5's ability to distinguish between psychiatric and community individuals and of the model's structural similarity in community samples, across studies and nationalities. More research is required to understand the Portuguese PID‐5 structure in clinical samples. © 2018 John Wiley & Sons, Ltd.
Migration processes and the underlying reasons: A study on pensioner migrants in Poland
Authors: Pytel Sławomir , Rahmonov Oimahmad 
Published: November 2018

AbstractAlthough population ageing is progressing, seniors migrate with increasing frequency. This paper explores the question why Polish pensioners decide to migrate, as existing research has not provided satisfactory explanations. Reasons for migrations were determined on the basis of pensioners' answers to a questionnaire survey. The results show that migration decisions are taken for a number of reasons, which depend, inter alia, on the respondents' education level, age, and sex. For women as well as for men, the economic aspect plays a crucial role (e.g., building or buying a new house). Ward's method was employed to distinguish five main migration types according to the main motivating factor; that is, family and finance, family, environmental, economic, and health. An analysis of internal as well as external migrations of Polish seniors shows that they differ considerably from migrations of seniors in other countries. Due to their unsatisfactory finances as well as deficits in knowledge of foreign languages, Polish pensioners, unlike their peers in other countries, rarely decide to settle down abroad. The Polish model of multigenerational family in which seniors assist their children in raising their grandchildren also contributes to lower emigration.
Generalized criteria on delay‐dependent stability of highly nonlinear hybrid stochastic systems
Authors: Fei Weiyin , Hu Liangjian , Mao Xuerong , Shen Mingxuan 
Published: November 2018

SummaryOur recent paper (Fei W, etal. Delay dependent stability of highly nonlinear hybrid stochastic systems. Automatica. 2017;82:165‐170) is the first to establish delay‐dependent criteria for highly nonlinear hybrid stochastic differential delay equations (SDDEs) (by highly nonlinear, we mean that the coefficients of the SDDEs do not have to satisfy the linear growth condition). This is an important breakthrough in the stability study as all existing delay stability criteria before could only be applied to delay equations where their coefficients are either linear or nonlinear but bounded by linear functions (namely, satisfy the linear growth condition). In this continuation, we will point out one restrictive condition imposed in our earlier paper. We will then develop our ideas and methods there to remove this restrictive condition so that our improved results cover a much wider class of hybrid SDDEs.
From Supramolecular Vesicles to Micelles: Controllable Construction of Tumor‐Targeting Nanocarriers Based on Host–Guest Interaction between a Pillar[5]arene‐Based Prodrug and a RGD‐Sulfonate Guest
Authors: Hu Xiao‐Yu , Gao Lei , Mosel Stefanie , Ehlers Martin , Zellermann Elio , Jiang Hao , Knauer Shirley K. , Wang Leyong , Schmuck Carsten 
Published: November 2018

AbstractThe targeting ability, drug‐loading capacity, and size of the drug nanocarriers are crucial for enhancing the therapeutic index for cancer therapy. Herein, the morphology and size‐controllable fabrication of supramolecular tumor‐targeting nanocarriers based on host–guest recognition between a novel pillar[5]arene‐based prodrug WP5‐DOX and a Arg‐Gly‐Asp (RGD)‐modified sulfonate guest RGD‐SG is reported. The amphiphilic WP5‐DOX⊃RGD‐SG complex with a molar ratio of 5:1 self‐assembles into vesicles, whereas smaller‐sized micelles can be obtained by changing the molar ratio to 1:3. This represents a novel strategy of controllable construction of supramolecular nanovehicles with different sizes and morphologies based on the same host−guest interactions by using different host−guest ratios. Furthermore, in vitro and in vivo studies reveal that both these prodrug nanocarriers could selectively deliver doxorubicin to RGD receptor‐overexpressing cancer cells, leading to longer blood retention time, enhanced antitumor efficacy, and reduced systematic toxicity in murine tumor model, suggesting their potential application for targeted drug delivery.
Piezophototronic Effect Modulated Multilevel Current Amplification from Highly Transparent and Flexible Device Based on Zinc Oxide Thin Film
Authors: Kumar Mohit , Kim Hong‐Sik , Lee Gyeong‐Nam , Lim Donggun , Kim Joondong 
Published: November 2018

AbstractIn this work, a strain modulated highly transparent and flexible ZnO/Ag‐nanowires/polyethylene terephthalate optoelectronic device is developed. By utilizing the applied external strain‐induced piezophototronic effects of a ZnO thin film, a UV‐generated photocurrent is tuned in a wide range starting from 0.01 to 85.07 µA and it is presented in a comprehensive map. Particularly, the performance of the device is effectively enhanced 7733 times by compressive strain, as compared to its dark current in a strain‐free state. The observed results are explained quantitatively based on the modulation of oxygen desorption/absorption on the ZnO surface under the influence of applied strains. The presented simple optoelectronic device can be easily integrated into existing planar structures, with potential applications in highly transparent smart windows, wearable electronics, smartphones, security communication, and so on.