bluuebunny/crossref_metadata_2025_split huggingface dataset:
In vitro apoptosis induction ability of methanolic extract of Paramignya trimera root (Xao tam phan) in breast cancer stem cells
Authors: Nguyen Sinh Truong , Hung Le Van Manh , Mai Nguyen Thi Thanh , Nhan Nguyen Trung , Hai Nguyen Xuan , Phan Ngoc Kim , Dinh Kiet Truong , Pham Phuc Van 
Published: August 2019

Objective: Cancer has been considered as one of the world's leading causes of death. Recently, the Paramignya trimera plant, locally called ``Xao Tam Phan'', has become a popular Vietnamese medicinal herb that is used as alternative medicine for cancer treatment support with minimal side effects. In this study, we aimed to demonstrate the cytotoxicity of methanolic extract of Paramignya trimera on a Vietnamese breast cancer stem cell line (VNBRCA1) in vitro.
Methods: We used the MTT assay to determine the cytotoxicity of the extract on VNBRCA1 cells and human fibroblast (HF) cell line was used as a control for the plant extract treatment. Clinically used anticancer drug, doxorubicin, was used as a control drug (for relative comparison to the plant extract) to evaluate the selective cytotoxicity of the plant extract on VNBRCA1 and HF cells. We examined the apoptosis induction by the plant extract on VNBRCA1by Annexin V/7AAD staining and flow cytometry analysis. In addition, the morphology of apoptotic nuclei of treated cells was observed by fluorescent microscopy using double fluorescent staining: Hoechst 33342 and propidium iodide (PI).
Results: In comparison between the cytotoxicity of the plant extract and Doxorubicin on both cell lines (VBRCA1 and HF), we observed that plant extract was selectively cytotoxic against VNBRCA1 with an IC50 value of 10610 μg/mL, while Doxorubicin was discriminatorily cytotoxic against HF with an IC50 value of 0.135+/-0.09 μg/mL. We also found that the plant extract induced apoptosis VNBRCA1 in a dose-dependent manner. In addition, fluorescent microscopy revealed disintegrated nuclei of plant extract-treated cells, representing a hallmark of apoptosis.
Conclusions: These results showed that Paramignya trimera methanolic extract selectively killed VNBRCA1 cell lines, indicating that Paramignya trimera methanolic extract may represent a potential agent for cancer treatment.
Extranjeros en Medellín. Motivaciones para su migración
Authors: Gómez Santa Gloria Mercedes , González Leivaz Daniela Liceth 
Published: August 2019

El texto presenta resultados de la investigación Colombia como país receptor de Flujos Migratorios Laborales: Preparándonos para el presente. Se muestran características familiares de personas extranjeras residentes en Medellín y resultados acerca de la motivación que tuvo la migración desde el proyecto de vida individual y familiar de las personas entrevistadas. Se encuentra la presencia cada vez más activa de familias de inmigrantes en Medellín por razones laborales y se reconoce la importancia de las redes como soporte para la adaptación en el lugar de destino.
Factor's Influencing Contractors Risk Attitude in the Malaysian Construction Industry
Authors: Taofeeq D. M. , Adeleke A. Q. 
Published: August 2019

The Malaysian construction industry often acts as a vehicle that motivates' the development of the nation's economy. The industry is commonly referred to as a catalyst for development. However, poor performance in terms of productivity and quality systems has been the main issues of discussion from most of the government reports. In order to improve performance in the Malaysian construction industry, the introduction of the Occupational Safety and Health Act (OSHA) in 1994 has made all industries in Malaysia to identify hazards, conduct risk assessment and control those risk and at the same time implement an integrated system to ensure consistency and better performance of projects in Malaysian industries. Therefore, in this paper, the ranking of specific factors affecting contractors' risk attitudes in the Malaysian construction industry was assessed. A review of relevant literature was undertaken to identify the factors influencing contractors' risk attitudes. The study found that the four leading specific factors influencing contractors risk attitude in the Malaysian construction industry are; Project Related Factors, Working capital, Human-Related Factors, and External Environment. The study confirms the individual factors that affect the contractor's risk attitudes. Knowledge of these factors will facilitate contractors' decision-making process and serve as a useful reference for further studies in the field of construction project management.
Keywords: Contractor's risk attitude, Malaysia, Risk attitude, Risk management
A State Legitimation Approach of Reserved Built Environment Professional Work - A Case for South Africa – Part 1
Authors: Manchidi T. E. , Rwelamila P. D. 
Published: August 2019

This paper borrows from the lenses of the sociology of professions, sociology of science and temporary project organisations and construction reform to examine state legitimation of reserved built environment (BE) professional work as the first part of a two-part study. In doing so, it examines the growth of professions as a consequence of the division of expert labour evolving to fill in knowledge gaps created by emergent social forces as other knowledge areas are rendered less relevant. It shows how professional work negatively impacts on the delivery efficiencies in the project as a temporary organisation. In making this argument, it draws on the jurisdictional theory of professions to illustrate the relational and interactional relationship of professions in construction projects. To help focus on collaboration, a preliminary conceptual model for the legitimation of professions at the macro (policy) level is developed to explain how boundary margins keep professions relational, and how the dynamics of boundary work unfold in a territorial space in a project (meso) environment. Finally, it provides the scope of the second part of the study (the field study) by formulating the main research objective and research question and their respective specific research objectives and research questions, respectively.
Keywords: Built Environment Professions, Division of Expert Labour, Jurisdictional Boundaries, Legitimation, Professional Work, Temporary Organisations
Bicalutamide plus Aromatase Inhibitor in Patients with Estrogen Receptor-Positive/Androgen Receptor-Positive Advanced Breast Cancer
Authors: Lu Qianyi , Xia Wen , Lee Kaping , Zhang Jingmin , Yuan Huimin , Yuan Zhongyu , Shi Yanxia , Wang Shusen , Xu Fei 
Published: August 2019

Abstract

Lessons Learned
Studies targeting the androgen receptor (AR) signaling pathway in aromatase inhibitor (AI)-resistant breast cancer are limited. Bicalutamide, one of the commonly used AR inhibitors in prostate cancer, in combination with AI, did not show synergistic activity in patients with estrogen receptor-positive and AI-resistant disease in this phase II, single-arm study. The clinical benefit rate and objective response rate at 6 months were 16.7% and 0%, respectively, and the study was terminated after the first stage.

Background
Endocrine resistance is a major problem in clinical practice. Studies have shown that androgen receptor (AR) signaling activation may be one of the mechanisms, and targeting AR showed some promising results in AR-positive triple-negative breast cancer. The aim of this study was to assess the efficacy and safety of bicalutamide plus another aromatase inhibitor in patients with nonsteroidal aromatase inhibitor (AI) or steroidal AI resistance and estrogen receptor (ER)-positive and AR-positive advanced breast cancer.

Methods
A Simon's two-stage, phase II, single-arm study was conducted. We assumed the clinical benefit rate (CBR) of 40% would be significant in clinical practice. In this case, if ≥4 patients of the 19 patients in the first stage benefited from treatment, the CBR would achieve the assumed endpoint. If fewer than four patients benefited from treatment in the first stage, the trial would be terminated. All patients received bicalutamide 50 mg per day orally plus another aromatase inhibitor. The primary outcome was CBR; secondary outcomes included objective response rate (ORR), progression-free survival (PFS), and tolerability.

Results
A total of 19 patients enrolled in the first stage, and 18 patients met all criteria for analysis. The trial terminated according to protocol after the first stage. After a median follow-up of 14 months, the CBR at 6 months was 16.7% (3/18); no patients with partial or complete response were observed. The median PFS was 2.7 months. Bicalutamide in combination with AI was well tolerated.

Conclusion
Bicalutamide in combination with another AI did not show synergistic activity in patients with ER-positive breast cancer and AI resistance. Results suggest that no more large-sample clinical trials should be conducted in this population for overcoming endocrine resistance.
Rapid Estimation of the Epicentral Distance in the Earthquake Early Warning System around the Tehran Region, Iran
Authors: Nazeri Sahar , Shomali Zaher Hossein 
Published: August 2019

ABSTRACT
The estimation of epicentral distance is a critical step in earthquake early warning systems (EEWSs) that is necessary to characterize the level of expected ground shaking. In this study, two rapid methodologies, that is, B‐Δ and C‐Δ, are evaluated to estimate the epicentral distance for use in the EEWSs around the Tehran region. Traditionally, the B and C coefficients are computed using acceleration records, however, in this study, we utilize both acceleration and velocity waveforms for obtaining a suitable B‐Δ and C‐Δ relationships for the Tehran region. In comparison with observations from Japan, our measurements fall within the range of scatter. However, our results show a lower trend, which can strongly depend on the few numbers of events and range of magnitude (small‐to‐moderate) of earthquakes used in the current research. To improve our result, we include some large earthquakes from Iran, Italy, and Japan with magnitude larger than 5.9. Although the optimal trend is finally obtained by fitting a line to the distance‐averaged points, we conclude that the same trend and relationship as Japan can be used in Tehran early warning system. We also found that B and C parameters are strongly compatible to each other. As time windows of 3.0 and 0.5 s after the P onset are chosen respectively to compute the B and C values, so by selecting the C parameter as a proxy of B parameter to estimate the epicentral distance, we may save significant time in order of about 2.5 s in any earthquake early warning applications.
Ortaokul Türkçe Dersi Öğretim Programlarında Sözlük Kullanma Alışkanlığı Kazandırmaya Dair Tespitler
Authors: MADEN Sedat , DEMİR Recep 
Published: August 2019

Bu çalışmada, ortaokul Türkçe dersi öğretim programlarının sözlük kullanma alışkanlığı kazandırmaya yönelik özelliklerinin tespit edilmesi amaçlanmaktadır. Bu çalışmada, nitel araştırma yaklaşımı benimsenmiştir. Cumhuriyetten günümüze kadar hazırlanan (1924-2018) ilköğretim ikinci kademe Türkçe dersi öğretim programlarında tespit edilen; sözlüğe yönlendiren, sözlük kullanmayı telkin ve teşvik eden kazanımlar ile çalışma sınırlandırılmıştır. Araştırma verilerinin toplanmasında doküman incelemesi tekniği kullanılmıştır. Çalışmanın veri kaynağı olan programlar, sözlük kullanma açısından ayrı ayrı incelenerek amaç ve açıklama ifadeleri tespit edilmiş, söz konusu olan program başlıklarına göre tasnif edilmiştir. Öğrencilerin sözlük kullanmasını doğrudan destekleyen ya da sözlük kullanmayı alışkanlık hâline getirilmesine katkıda bulunan ifadeler her programın ilgili bölüm başlığı altında toplanıp içerik analizine tabi tutulmuştur. Sözlük kullanmaya ilişkin ifadeler öğrenme alanı ve sınıf düzeyine göre değerlendirilerek yorumlanmıştır. Araştırma sonucunda, 1924 yılından bugüne her programda sözlük kullanmaya dair bir amaç ve uygulama açıklamasının olduğu, ancak 2005 yılından sonraki programlarda daha ayrıntılı ve yoğun biçimde sözlük kullanmaya dair amaç ve açıklamaların bulunduğu tespit edilmiştir.
A prospective clinical study to evaluate the correlation of duration of kangaroo mother care and weight gain in low birth weight babies
Authors: Gagandeep Vijayalaxmi , R. Chaithra , K. Febina 
Published: August 2019

Background: Kangaroo Mother Care (KMC) is an alternative to conventional neonatal care for low birth weight (LBW) babies in low resource settings, this study is to evaluate the correlation between the duration of KMC given and average weight gain per day in low birth weight babiesMethod: It is an observational study, 106 low birth weight babies who were less than 1.8 kg, hemodynamically stable, accepting either direct breast feed or gavage feed were included in the study, duration of KMC given per day and weight was recorded daily until discharge. Babies were monitored for complications, if any babies were withdrawn from the study , necessary intervention was done. Average weight gain per day in these babies was estimated and correlated with the average duration of KMC.Results: Out of 120 eligible children 106 were selected for study of which 57 were male and 49 were female, 42 were less than 1.2 kg, 37 were between 1.21 kg to 1.5 kg and 27 were between 1.51 kg to 1.8 kg, there was statistically significant moderate correlation with Pearson r=0.6281 with p value <0.00001 and mean average weight gain was 5.27 in less than 6 hr to 8 hr, 9.08 in 8 hr to 10 hr, 11.87 in greater than 10 hrs of KMCConclusion: The weight gain was found to increase with duration of KMC practice. hence authors recommend to increase the duration of KMC per day for the good average weight gain per day.
COMPLEXITIES IN A FLEXIBLE SUPPLY CHAIN AND THE ROLE OF KNOWLEDGE TRANSFER
Authors: Jermsittiparsert Kittisak , Srisawat Supamit 
Published: August 2019

Purpose: The current study is interested in exploring the nexus between product complexities, external and internal knowledge and supply chain flexibility of Indonesian manufacturing firms.
Methodology: The study has employed the knowledge-based view to conceptualize the relationship between product complexities, external and internal knowledge and supply chain flexibility of Indonesian manufacturing firms. The complexity of manufacturing flexibility has made this concept difficult to comprehend yet delimit. To date, agreement on how to practice this concept has not yet been resolved. Employing the survey-based methodology, the SEM-PLS technique is used to test the hypothesized relationships. So, the current study has used SEM-PLS as a statistical tool to answer the research questions raised in this study and research objectives envisaged in the current study.
Results: The findings of the study have provided support to the theoretical foundation and proposed hypothesis of the current study. Current study will be helpful for policymakers and practitioners in understanding the issues related to supply chain risk, supply chain integration and supply chain agility. In the author's knowledge this is among very few pioneering studies on this issue.
THE FIRM’S STRATEGIC ORIENTATIONS AND ENVIRONMENTAL UNCERTAINTIES AS ANTECEDENTS OF ITS SUPPLY CHAIN AGILITY
Authors: Jermsittiparsert Kittisak , Wajeetongratana Prateep 
Published: August 2019

Purpose: The main objective of the current study is exploring the impact of firm’s strategic orientation on the supply chain agility. In addition to that the current study has examined the impact of environmental uncertainties on the agile supply chain. Therefore, the study is among the pioneering studies on the issues. This research study contributes to the existing literature.
Methodology: The research has worked on the need for analyzing the influence of supply chain and market orientation on supply chain agility of a firm so, current study has used hierarchal regression as statistical tool to answer the research questions raised in this study and research objectives envisaged in the current study.
Results: The findings of the current study have provided support to with the proposed. The results have shown that the along with customer focus approach the firms are also following the production focus approach. The findings pf the study will be helpful for policy makers in understanding the issues related to integration supply chain management. In author knower this is among few pioneering studies on these issues.
Structure démographique et régénération naturelle des peuplements naturels de Pterocarpus erinaceus Poir. (Fabaceae) des savanes de Côte d’Ivoire
Authors: Goba Alice Estère , Koffi Kouamé Guillaume , Sié Raoul Sylvère , Kouonon Léonie Clémence , Koffi Yeboa Alexis 
Published: August 2019

Pterocarpus erinaceus Poir. (Fabaceae) est un arbre des forêts claires et des savanes arborées d’Afrique, très prisé pour son bois, son fourrage et ses vertus thérapeutiques, cause de sa surexploitation en Côte d’Ivoire. La présente étude analyse la structure démographique des peuplements naturels et les potentialités de régénération de cette essence en fonction de l’intensité d’exploitation dans les trois types de savanes (guinéenne, subsoudanienne et soudanienne) de la Côte d’Ivoire en vue de leur conservation. Des mesures dendrométriques (diamètre à 1,30 m du sol, hauteur totale et hauteur du fût de l’arbre) ont été effectuées dans 30 transects de 200 m de large, sur des individus de P. erinaceus de diamètre égal ou supérieur à 5 cm dans six sites. La régénération a été évaluée dans 186 placettes de 30 m x 30 m équidistantes de 50 m à l’intérieur des transects. Les résultats révèlent que les plus grandes valeurs moyennes de densité d’arbres et de densité de régénération ont été obtenues en savane guinéenne (9,9 arbres/ha et 33,8 tiges/ha) et subsoudanienne (12,6 arbres/ha et 25,2 tiges/ha) alors que le diamètre moyen (33,9 cm), la hauteur totale moyenne (10,6 m) et la hauteur moyenne du fût (3,83 m) présentent des valeurs significativement plus élevées (p < 0,001) en savane soudanienne. L’étude montre que l’espèce se régénère par semis naturels, rejets de souche et drageons. La distribution en classe de diamètre s’ajuste à la distribution de Weibull avec une forme en « J renversé » en savane guinéenne et subsoudanienne et en « cloche » en savane soudanienne avec des arbres de taille moyenne. Hormis l’aire protégée de Kouassi-Ndawa, les cinq autres peuplements sont soumis à diverses pressions anthropiques (coupes, écorçage et émondage).
Metode Role play Meningkatkan Pengetahuan dan Tindakan Pertolongan Pertama Luka Pada Anak Usia Sekolah Dasar di Daerah Rawan Bencana
Authors: Saputra Wirahadi , Krisnana Ilya , Kurnia Iqlima Dwi , Kusumaningrum Tiyas 
Published: August 2019

Introduction: Knowledge and skill of school age children is still lack about first aid of wound. The purpose of this study was to determine the effect of role play methodtowards knowledge and wound first aid skill on student. The aim of experiment is to study the effect of role play method towards knowledge and wound first aid skill on student.Methods: The design used in this study was quasi-experimental quasi-eksperimental pretest-posttest control group design. The samples were gathered using simple random sampling method consisted of 50 students based on the inclusion criteria which were divided into experimental and control groups. The independent variable was health education using role play methods and the dependent variables were knowledge and first aid wound skill. The data were analyzed by using Wilcoxon Signed Rank Test and Mann Whitney U Test with level significance α<0,05.Results: The Wilcoxon Signed Rank Test results showed that there were enhancement for knowledge (p=0.000) and first aid wound skill(p=0.000) for post intervention toward the experimental group. These data were strengthened by the result of Mann Whitney U Test statistical analysis that showed the significant differences for knowledge (p=0.000) and action application of open wounds care (p=0.000).Conclusion: It can be concluded that health education using role play methods affected knowledge and wound first aid skill on student. The suggestion for the further experiment is to compare role play methods with other health education methods to find out effective methods of health education for student.
Solution of the Immiscible Fluid Flow Simulation Equations
Authors: Breitenbach E. A. , Thurnau D. H. , van Poolen H. K. 
Published: August 2019

ABSTRACT
This paper presents the methods used to solve the finite difference equations which were developed in a companion paper (1). Various possible methods of solution are discussed. Experience has narrowed the number of suitable numerical methods that are practical to three: Gauss elimination, successive overrelaxation, and the iterative alternating direction implicit process. The final sections of the paper are devoted to a presentation of computational techniques which are vital to actual use of each of the above-mentioned methods.
All the terms are defined in the paper. Here, however, we have dropped the subscript denoting the pressure, p, as an oil pressure. Further breakdown requires definition of the numerical solution to be used. This paper describes the breakdown and solution processes most often used in the MUFFS program. Sufficient detail is given so that computer programming can be done.
Contrary to popular opinion, economic simulation has been found to require the development of several solution methods, rather than relying on a single one. This requires that the computer subprogram for generating coefficients (A's and O's) be written as a distinct, separate entity to supply the coefficients in Equation (1). Furthermore, it is necessary to be able to obtain these coefficients automatically in column-by-column, row-by-row, or point-by-point form, in any order required by a numerical solution. Columns, rows, and points refer to the columns, rows, and points of the finite difference grid. A program that can generate coefficients in several forms is a simple but important concept, for it allows the easy insertion and modification of experimental methods. The computing inefficiencies that may be incurred within a general coefficient generator are small in comparison to the computing time saved by using the fastest of several solution techniques.
A novel electrochemical aptasensor for fumonisin B1 determination using DNA and exonuclease-I as signal amplification strategy
Authors: Wei Min , Zhao Fei , Feng Shuo , Jin Huali 
Published: August 2019

Abstract
In this work, using DNA and exonuclease-I (Exo-I) as signal amplification strategy, a novel and facile electrochemical aptasensor was constructed for fumonisin B1 (FB1) detection. The G-rich complementary DNA (cDNA) was immobilized onto the electrode surface. Then, aptamer of FB1 was hybridized with cDNA to form double-stranded DNA. In the absence of FB1, double-stranded DNA and G-rich cDNA on the electrode surface promoted effectively methylene blue (MB) enrichment and amplified the initial electrochemical response. In the presence of FB1, the combination of aptamer and FB1 led to the release of aptamer from the electrode surface and the expose of 3' end of single-stranded cDNA. When Exo-I was added onto the electrode surface, the single-stranded cDNA was degraded in the 3’-5’ direction. The decrease of double-stranded DNA and G-rich cDNA resulted in the less access of MB to the electrode surface, which decreased the electrochemical signal. The experimental conditions including incubation time of FB1, the amount of Exo-I and incubation time of Exo-I were optimized. Under the optimal conditions, the linear relationship between the change of peak current and the logarithmic concentration of FB1 was observed in the range of 1.0×10-3-1000ng·mL−1 with a low limit of detection of 0.15 pg·mL−1. The experimental results showed that the prepared aptasensor had acceptable specificity, reproducibility, repeatability and stability. Therefore, this proposed aptasensor has a potential application in the food safety detection.