bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cell grazing and Haemonchus contortus control in sheep: lessons from a two-year study in temperate Western Europe
Authors: Ruiz-Huidobro C. , Sagot L. , Lugagne S. , Huang Y. , Milhes M. , Bordes L. , Prévot F. , Grisez C. , Gautier D. , Valadier C. , Sautier M. , Jacquiet P. 
Published: September 2019

AbstractManaging infections of sheep with anthelmintic resistant gastrointestinal nematodes (GIN) is a major challenge for sheep producers in Western Europe. New methods of grazing management have been poorly explored as a component of an integrated and sustainable control of these parasites. Therefore, the purpose of this study was to evaluate the effect of two different types of grazing systems of sheep (intensive cell grazing versus conventional rotational grazing) on GIN infections over two years in a farm located in a temperate environment of Western France. When considering the whole study, the type of grazing system did not influence significantly the intensity of egg excretions of adult ewes even if the proportion of ewes excreting high numbers of GIN eggs was higher in cell grazing system than in rotational grazing system. The most striking result of this survey was the effect of grazing system on the GIN species composition harbored by ewes and by their lambs: with time, the proportions of H. contortus infections were lower in cell grazing system than in rotational grazing system. In conclusion, the cell grazing system, as implemented in this study, could limit the importance of this highly pathogenic nematode species in sheep.
Safety and neurochemical profiles of acute and sub-chronic oral treatment with agmatine sulfate
Authors: Bergin David H. , Jing Yu , Williams Gail , Mockett Bruce G. , Zhang Hu , Abraham Wickliffe C. , Liu Ping 
Published: September 2019

AbstractAgmatine (decarboxylated arginine) exerts numerous central nervous system (CNS) dependent pharmacological effects and may potentially modulate altered neurochemistry seen in neurological disorders. In preclinical studies, injection has been the predominant route of systemic administration. However, a significant translational step would be the use of oral agmatine treatment at therapeutic doses and better understanding of L-arginine metabolic profiles in the CNS post-treatment. The present study systematically investigated the tolerability, safety and brain-plasma neurochemistry following daily oral agmatine sulfate treatment (via gavage) to wild-type (WT) mice up to 900 mg/kg for one week (Experiment 1) or WT and APPswe/PS1ΔE9 transgenic (Tg) mice at 300 mg/kg for fifteen weeks (Experiment 2). Agmatine treatment in both experiments was well tolerated with no marked behavioural impairments, and gross necropsy and organ histology revealed no pathological alterations after 15-week dosing. Moreover, oral treatment increased agmatine levels in the hippocampus and plasma of WT mice (Experiment 1), and in 6 brain regions examined (but not plasma) of WT and Tg mice (Experiment 2), at 30 minutes or 24 hours post-treatment respectively. This study provides fundamental pre-clinical evidence that daily oral delivery of agmatine sulfate to both WT and Tg mice is safe and well tolerated. Exogenous agmatine passes through the blood brain barrier and accumulates in the brain to a greater extent in Tg mice. Furthermore exogenous agmatine has differential actions in the brain and periphery, and its effect on brain putrescine appears to be dependent on the time post-treatment.
Efficient generation of Knock-in/Knock-out marmoset embryo via CRISPR/Cas9 gene editing
Authors: Kumita Wakako , Sato Kenya , Suzuki Yasuhiro , Kurotaki Yoko , Harada Takeshi , Zhou Yang , Kishi Noriyuki , Sato Kengo , Aiba Atsu , Sakakibara Yasubumi , Feng Guoping , Okano Hideyuki , Sasaki Erika 
Published: September 2019

AbstractGenetically modified nonhuman primates (NHP) are useful models for biomedical research. Gene editing technologies have enabled production of target-gene knock-out (KO) NHP models. Target-gene-KO/knock-in (KI) efficiency of CRISPR/Cas9 has not been extensively investigated in marmosets. In this study, optimum conditions for target gene modification efficacies of CRISPR/mRNA and CRISPR/nuclease in marmoset embryos were examined. CRISPR/nuclease was more effective than CRISPR/mRNA in avoiding mosaic genetic alteration. Furthermore, optimal conditions to generate KI marmoset embryos were investigated using CRISPR/Cas9 and 2 different lengths (36 nt and 100 nt) each of a sense or anti-sense single-strand oligonucleotide (ssODN). KIs were observed when CRISPR/nuclease and 36 nt sense or anti-sense ssODNs were injected into embryos. All embryos exhibited mosaic mutations with KI and KO, or imprecise KI, of c-kit. Although further improvement of KI strategies is required, these results indicated that CRISPR/Cas9 may be utilized to produce KO/KI marmosets via gene editing.
Migrating eastern North Pacific gray whale call and blow rates estimated from acoustic recordings, infrared camera video, and visual sightings
Authors: Guazzo Regina A. , Weller David W. , Europe Hollis M. , Durban John W. , D’Spain Gerald L. , Hildebrand John A. 
Published: August 2019

AbstractDuring the eastern North Pacific gray whale 2014–2015 southbound migration, acoustic call recordings, infrared blow detections, and visual sightings were combined to estimate cue rates, needed to convert detections into abundance. The gray whale acoustic call rate ranged from 2.3–24 calls/whale/day during the peak of the southbound migration with an average of 7.5 calls/whale/day over both the southbound and northbound migrations. The average daily calling rate increased between 30 December–13 February. With a call rate model, we estimated that 4,340 gray whales migrated south before visual observations began on 30 December, which is 2,829 more gray whales than used in the visual estimate, and would add approximately 10% to the abundance estimate. We suggest that visual observers increase their survey effort to all of December to document gray whale presence. The infrared camera blow rate averaged 49 blows/whale/hour over 5–8 January. Probability of detection of a whale blow by the infrared camera was the same at night as during the day. However, probability of detection decreased beyond 2.1 km offshore, whereas visual sightings revealed consistent whale densities up to 3 km offshore. We suggest that future infrared camera surveys use multiple cameras optimised for different ranges offshore.
Exploring the diversity of Poaceae-infecting mastreviruses on Reunion Island using a viral metagenomics-based approach
Authors: Claverie Sohini , Ouattara Alassane , Hoareau Murielle , Filloux Denis , Varsani Arvind , Roumagnac Philippe , Martin Darren P. , Lett Jean-Michel , Lefeuvre Pierre 
Published: September 2019

AbstractMostly found in Africa and its surrounding islands, African streak viruses (AfSV) represent the largest group of known mastreviruses. Of the thirteen AfSV species that are known to infect either cultivated or wild Poaceae plant species, six have been identified on Reunion Island. To better characterize AfSV diversity on this island, we undertook a survey of a small agroecosystem using a new metagenomics-based approach involving rolling circle amplification with random PCR amplification tagging (RCA-RA-PCR), high-throughput sequencing (Illumina HiSeq) and the mastrevirus reads classification using phylogenetic placement. Mastreviruses that likely belong to three new species were discovered and full genome sequences of these were determined by Sanger sequencing. The geminivirus-focused metagenomics approach we applied in this study was useful in both the detection of known and novel mastreviruses. The results confirm that Reunion Island is indeed a hotspot of AfSV diversity and that many of the mastrevirus species have likely been introduced multiple times. Applying a similar approach in other natural and agricultural environments should yield sufficient detail on the composition and diversity of geminivirus communities to precipitate major advances in our understanding of the ecology and the evolutionary history of this important group of viruses.
Analysis of Amount and Style of Oral Interaction Related to Language Outcomes in Children With Hearing Loss: A Systematic Review (2006–2016)
Authors: Sultana Nuzhat , Wong Lena L. N. , Purdy Suzanne C. 
Published: September 2019

PurposeThis systematic review summarizes the evidence for differences in the amount of language input between children with and without hearing loss (HL). Of interest to this review is evaluating the associations between language input and language outcomes (receptive and expressive) in children with HL in order to enhance insight regarding what oral language input is associated with good communication outcomes.MethodA systematic review was conducted using keywords in 3 electronic databases: Scopus, PubMed, and Google Scholar. Keywords were related to language input, language outcomes, and HL. Titles and abstracts were screened independently, and full-text manuscripts meeting inclusion criteria were extracted. An appraisal checklist was used to evaluate the methodological quality of studies as poor, good, or excellent.ResultsAfter removing duplicates, 1,545 study results were extracted, with 27 eligible for full-text review. After the appraisal, 8 studies were included in this systematic review. Differences in the amount of language input between children with and without HL were noted. Conversational exchanges, open-ended questions, expansions, recast, and parallel talk were positively associated with stronger receptive and expressive language scores. The quality of evidence was not assessed as excellent for any of the included studies.ConclusionsThis systematic review reveals low-level evidence from 8 studies that specific language inputs (amount and style) are optimal for oral language outcomes in children with HL. Limitations were identified as sample selection bias, lack of information on control of confounders and assessment protocols, and limited duration of observation/recordings. Future research should address these limitations.
Energy storage solution for wireless sensor network used in bridge surface corrosion monitoring
Authors: Fujimoto T. , Uto S. , Ishizuka Y. , Fujishima T. , Guan C.‐E. , Okumatsu T. , Sugimoto S. , Iwasaki S. 
Published: August 2019

This Letter presents a radio‐frequency energy storage solution for monitoring corrosion on bridge in wireless sensor network system. In this monitoring system, wireless terminals and sensors are installed on the bridges to monitor surface corrosion remotely. The proposed energy storage module to supply power to the sensors consists of a rectifier, a supercapacitor, and a DC–DC boost converter. The rectifier circuit is designed to convert 920 MHz RF energy to DC source. Experimental results demonstrate that the harvested energy can power up the sensor nodes for several times in a week, at input power density of 0.81 μW/cm2.
Demonstration of modulating retro‐reflection free‐space optical transmission using 80 Gb/s Pol‐MUX QPSK signal in simulated atmosphere environment
Authors: Feng Xianglian , Jiang Hexin , Wu Zhihang , Wang Tianshu , Jiang Huilin , Gao Shiming 
Published: August 2019

The authors experimentally demonstrate a modulating retro‐reflector based on electro‐optical in‐phase quadrature modulator and test it in an atmospheric cell simulated atmosphere environment by using 80 Gb/s polarisation‐multiplexing quadrature phase‐shift keying (Pol‐MUX QPSK) signals. At the BER of 1 × 10−3, the power penalties of the x‐ and y‐polarisation signals are both <1.1 dB when the temperature difference in the atmospheric cell is <250°C.
High‐selective triple‐mode bandpass filter using a new capacitive‐loaded patch resonator
Authors: Liu Qing , Zhou Dongfang , Zhang Dewei , Wang Xian 
Published: August 2019

This Letter proposes a novel high‐selective triple‐mode bandpass filter based on a patch resonator. The new triple‐mode patch resonator is realised by the traditional dual‐mode square patch with a floating capacitive‐loaded metal patch. The resonance of one higher‐order mode can be independently shifted to that of two fundamental modes to form a passband. Based on the proposed filter, three finite‐transmission zeros can be produced, and two of them can be controlled well. For the demonstration, a triple‐mode patch filter with the centre frequency of 3.5 GHz was designed, fabricated and measured.
Update Mammakarzinom 2019 Teil 1 – Implementierung der Ergebnisse neuer Studienkonzepte beim frühen Mammakarzinom in die klinische Praxis
Authors: Hartkopf Andreas D. , Müller Volkmar , Wöckel Achim , Lux Michael P. , Janni Wolfgang , Nabieva Naiba , Taran Florin-Andrei , Ettl Johannes , Lüftner Diana , Belleville Erik , Schütz Florian , Fasching Peter A. , Fehm Tanja N. , Kolberg Hans-Christian , Overkamp Friedrich , Schneeweiss Andreas , Tesch Hans 
Published: August 2019

ZusammenfassungIn der Prävention und Behandlung des frühen Mammakarzinoms sind über die Jahre immer wieder kleine, aber bedeutsame Fortschritte gemacht worden. In der Prävention gewinnen die sogenannten Panel-Gen-Analysen immer mehr an Bedeutung, da das durch die getesteten Gene bedingte Risiko immer besser verstanden wird und somit Konzepte für die Integration in die Krankenversorgung erarbeitet werden können. In der adjuvanten Situation konnte die erste Studie in der sogenannten post-neoadjuvanten Situation bei fehlender pathologischer Komplettremission nach Trastuzumab oder Pertuzumab + Trastuzumab eine deutliche Verbesserung der Prognose zeigen. Weitere Studien mit diesem post-neoadjuvanten Therapiekonzept werden zurzeit noch durchgeführt. Die CDK4/6-Inhibitoren, die in der metastasierten Situation eine deutliche Verbesserung des progressionsfreien Überlebens gezeigt hatten, werden zurzeit in der adjuvanten Situation in großen Therapiestudien getestet. Diese und weitere neue Daten zur Behandlung oder Prävention des primären Mammakarzinoms werden in dieser Übersichtsarbeit vor dem Hintergrund aktueller Studien vorgestellt.
Update Mammakarzinom 2019 Teil 2 – Implementierung neuer Diagnostika und Therapien bei Patientinnen mit fortgeschrittenem Brustkrebs in der klinischen Praxis
Authors: Janni Wolfgang , Schneeweiss Andreas , Müller Volkmar , Wöckel Achim , Lux Michael P. , Hartkopf Andreas D. , Nabieva Naiba , Taran Florin-Andrei , Tesch Hans , Overkamp Friedrich , Lüftner Diana , Belleville Erik , Schütz Florian , Fasching Peter A. , Fehm Tanja N. , Kolberg Hans-Christian , Ettl Johannes 
Published: August 2019

ZusammenfassungDie Behandlung von Patientinnen mit fortgeschrittenem Mammakarzinom hat sich in den letzten Jahren weiterentwickelt. Zusätzlich zum Therapiefortschritt in den etablierten Subgruppen (Hormonrezeptor- und HER2-Status) gibt es nun Therapien, die sich an einzelnen molekularen Charakteristika orientieren, wie zum Beispiel die PARP-Inhibitor-Therapie bei BRCA-mutierten Patientinnen. Zusätzlich dazu sind Tests in der Entwicklung, die innerhalb von Subgruppen weitere Marker etablieren sollen, um die Wirksamkeit einer Therapie vorherzusagen. Die PI3K-Mutationstestung bei HER2-negativen, hormonrezeptorpositiven Tumoren und die PD‑L1-Testung von Immunzellen bei triple-negativen Tumoren werden voraussichtlich in der klinischen Praxis etabliert, um Patientinnen für die jeweiligen Therapien auszuwählen. Mit neuen Therapieansätzen treten auch neue Nebenwirkungen auf. Das Management dieser Nebenwirkungen ebenso wie die der klassischen Therapien (supportive Therapie) ist mit der Einführung neuer Behandlungen essenziell, um die Lebensqualität der Patientinnen zu erhalten. Das Wissen über Maßnahmen zur Erhaltung und Verbesserung der Lebensqualität hat in den letzten Jahren deutlich zugenommen. Lifestyle-Faktoren sollten dabei ebenso Berücksichtigung finden wie moderne Therapieverfahren. Diese Übersichtsarbeit fasst die neuesten Studien und Veröffentlichungen zusammen und bewertet sie in Bezug auf die Relevanz für die klinische Praxis.
Evolution of Blepharoplasty
Authors: Hicks Katherine , Sclafani Anthony P. , Thomas James Regan 
Published: August 2019

AbstractThe eyes and periorbital region are central components of facial beauty and harmony, but the periorbital region is also one of the earliest to show signs of aging. Over the past few decades, significant progress has been made in our understanding of the anatomy in this area, as well as the deleterious effects of aging in this region. In turn, surgical philosophy and techniques have evolved to better combat changes in this area to achieve a more youthful, natural appearance.
Once Upon a Rhinoplasty: The History of the “Queen” of Facial Plastic Surgery
Authors: Adamson Peter A. , Gantous Andres 
Published: August 2019

AbstractThe history of rhinoplasty is absolutely fascinating. It is replete with mysterious practices, intrigue, and imaginative thoughts. If necessity is the mother of invention, then sex, crimes, and punishment lay a legitimate claim to being the mother of rhinoplasty. The history of rhinoplasty is a global saga spanning the millennia. Practitioners of the art and science have included those demonstrating the most admirable traits espoused in the Hippocratic Oath, as well as those to whom the word “charlatan” might more aptly be applied. The truth of a story is illustrated in its telling, and we have attempted to be true historians. We recognize that observers and narrators, now well past (sic), have determined many of today's truths, and therefore their stories become our truths whether they were so or not. We have attempted to reference many who have contributed to the advance of this amazing surgical procedure, recognizing that we may have included some who have demonstrated marginal merit to be so. Assuredly, we have also unintentionally omitted some whom we should have included. From them we ask forbearance. Let the story begin, “Once upon a time…”
Return to Play after Anterior Cruciate Ligament Reconstruction among Amateur Soccer Players
Authors: Alonso Julián , Malig Samuel , Fontboté Cristián , Azar Camilo , Vergara Francisco , Yáñez Roberto 
Published: September 2019

Abstract
Objective The aim of the present study is to assess the return to play among amateur soccer league players after anterior cruciate ligament (ACL) reconstruction.
Materials and Method The surgical protocols of ACL reconstruction surgeries performed in a sports medicine clinic from July 1st, 2013, to June 30th, 2014, were included in the study. Only the charts of amateur soccer league players who played once or twice a week were selected. The follow-up time was calculated as the number of months between surgery and the telephone survey. At the follow-up, the current status of the soccer playing was recorded. Those patients who were no longer playing in a team were asked what kind of sport they were currently practicing, as well as the main reason for not returning to team playing.
Results A total of 61 (25.6%) patients met the inclusion criteria. The mean follow-up time was of 22.4 ± 3.4 months. At the follow-up, 30 (49.1%) patients were playing in amateur soccer teams. Among the patients who were no longer playing in a team, 19 (61.2%) were playing soccer occasionally, 11 (35.4%) were practicing other sports, and 1 developed a sedentary life style. The reasons for not returning to team playing were: fear of reinjury in 26%; knee symptoms in 26%; lack of confidence in the knee in 23%, family or job commitments in 23%; and not being eligible to participate in competitive sports in 2%.
Conclusion After an average of two years of ACL reconstruction, only half of the amateur soccer league players return to play.
Patellar Impingement on Tibial Polyethylene after Primary Total Knee Arthroplasty without Patellar Resurfacing
Authors: Hwang Bo-Hyun , Jung Kwang-Am , Ong Alvin , Ahn Hye-Sun , Moon Seong-Hwan , Lee Su-Chan 
Published: August 2019

AbstractPatellar impingement on tibial polyethylene (PIP) is one potential complication of total knee arthroplasty (TKA). When PIP occurs, it is often related to inaccurate restoration of the joint line or due to soft-tissue contracture. We investigated the prevalence and etiology of PIP in Asian patients with deeply flexed knees following posterior stabilized (PS)-TKA. We retrospectively reviewed 54 patients (65 knees) with PIP after primary PS-TKAs without patellar resurfacing performed between 2008 and 2011. These patients were compared with a group of 124 patients (130 knees) without PIP matched for age, sex, and body mass index (BMI). The minimum follow-up was 5 years (range, 5–8.1 years). Patients were evaluated by blinded, independent observers using the Oxford knee score, the Waters score, and radiographic parameters. Impingement between the patella and the tibial polyethylene had a mean onset of 13.5 months after PS-TKA. The development of PIP was significantly associated with change in patellar tendon length (odds ratio [OR] = 11.4, 95% confidence interval [CI]: 11.2–11.6%), shorter postoperative patellar tendon length (OR = 2.1, 95% CI: 1.8–2.5%), change in the Insall–Salvati ratio (OR = 0.9, 95% CI: 0.8–1.0%), and joint line elevation (OR = 5.3, 95% CI: 4.8–5.8%) on multiple logistic regression analysis. Our findings reinforce the importance of accurate joint line restoration and the avoidance of iatrogenic injury to the patellar tendon, which can lead to shortening of the patellar tendon. This is a retrospective comparative study and its level of evidence is III.
Prone versus Supine Position for Lung Ultrasound in Neonates with Respiratory Distress
Authors: Louis Deepak , Belen Karen , Farooqui Mansoor , Idiong Nnanake , Amer Reem , Hussain Abrar , ElSayed Yasser 
Published: September 2019

Objective To study the feasibility of lung ultrasound (LUS) in prone position and to compare it with supine position in neonates with respiratory distress.Study Design Neonates ≥ 29 weeks of gestational age with respiratory distress requiring respiratory support within first 12 hours of life were enrolled prospectively. First LUS (fLUS) was done in the position infant was nursed (supine or prone), infant’s position changed, a second LUS (sLUS) was performed immediately and a third LUS (tLUS) was done 1 to 2 hours later. Primary outcome was the comparison of LUS scores (LUSsc) between fLUS and sLUS.Results Sixty-four neonates were enrolled. Common respiratory diagnoses were transient tachypnea of newborn (TTN; 53%) and respiratory distress syndrome (RDS; 41%). LUSsc was different between fLUS and sLUS (fLUSsc 6 [interquatile range: 4, 7] vs. sLUSsc 7 [4, 10], p < 0.001), while there was no difference between the fLUS and tLUS (fLUSsc 6 [4, 7] vs. tLUSsc 5 [3, 7], p = 0.43). Subgroup analysis confirmed similar findings in neonates with TTN, while in babies with RDS, all the three LUSsc were similar.Conclusion LUS is feasible in prone position in neonates. LUS scores were higher immediately after a change in position but were similar to baseline 1 hour after the change in position.
Historical records reveal the distinctive associations of human disturbance and extreme climate change with local extinction of mammals
Authors: Wan Xinru , Jiang Guangshun , Yan Chuan , He Fangliang , Wen Rongsheng , Gu Jiayin , Li Xinhai , Ma Jianzhang , Stenseth Nils Chr. , Zhang Zhibin 
Published: September 2019

Significance
Human impacts and climatic changes are widely considered to be responsible for rapid species extinction. However, determining their effects is challenging owing to the lack of long-term spatial–temporal data. In this study, we quantified the distinctive associations of anthropogenic and climatic stressors with the local extinction of 11 medium- or large-sized mammals using historical records over the past 3 centuries. We found that the increased local extinction of mammals was associated with intensified human disturbance (particularly for large-sized mammals) and with extreme temperature change (both cooling and warming). Our results provide insight into biodiversity conservation during the Anthropocene.