bluuebunny/crossref_metadata_2025_split huggingface dataset:
Optical Property and Photoelectrical Performance of a Low-bandgap Conducting Polymer Incorporated with Quantum Dots Used for Organic Solar Cells
Authors: Thao Tran Thi , Hai Vu Thi , Dinh Nguyen Nang , Trong Le Dinh 
Published: April 2018

By using spin-coating technique, a low bandgap conjugated polymer, poly[2,6-(4,4-bis-(2-ethylhexyl)-4H-cyclopen-ta[2,1-b;3,4-b′]dithiophene)-alt-4,7-(2,1,3-benzothiadiazole)] (PCPDTBT) and its composite thin films have been prepared. The optical absorption and photoconductive properties with over a wide spectral range, from 350 to 950 nm, were characterized. The obtained results showed that PCPDTBT:10 wt% CdSe composite is the most suitable for efficient light-harvesting in polymer-based photovoltaic cells. The photoelectrical conversion efficiency (PCE) of the device with a multilayer structure of ITO/PEDOT/ PCPDTBT:CdSe /LiF/Al reached a value as large as 1.34% with an open-circuit voltage (Voc) = 0.57 V, a short-circuit current density (Jsc) = 4.29 mA/cm2, and a fill factor (FF) = 0.27. This suggests a useful application in further fabrication of quantum dots/polymers based solar cells.
Enhancement of Lasing Emission in the Metalliccoated Microsphere Cavity Based on Er-doped Silica Glasses
Authors: Hoi Pham Van , Anh Nguyen The , Trang Nguyen Thi Thu , Thang Le Huu , An Nguyen Van 
Published: April 2018

In this paper, we present a review of enhancement and wavelength shift of abnormal upconversion green light emission from erbium ions doped in silica with narrow linewidth in the metallic-coated microsphere cavity. Although the phenomenon of the 537 nm- green light emission is not yet understood, its enhancement of several orders of magnitude seems to be due to the excitation of plasmons. The metallic-coated microsphere cavity has led to the lowest threshold so far observed in microsphere cavity lasers from 0.2 mW to 60 nW. By combining microcavity and surface plasmonic enhancement effect the researchers have created a new kind of photonic devices.
Facile Synthesis of Carbon Quantum Dots by Plasma-liquid Interaction Method
Authors: Tung Do Hoang , Thuong Tran Thi , Cong Nguyen Dinh , Liem Nguyen Thanh , Kha Nguyen Van , Manh Le Hong , Minh Pham Hong , Thuy Nguyen Thi Thu , Hoa Nguyen Minh , Phu Nguyen Van 
Published: April 2018

Carbon quantum dots (CQDs) are a novel type of	fluorescent nano-materials with various unique properties. They are recently	attracting enormous interest due to their superiority in water solubility,	chemical inertness, low toxicity, ease of functionalization as well as	resistance to photo-bleaching and potential applications in biomedical	indication, photo-catalysis, energy conversion, optoelectronics, and	sensing. In this work, we present a facile and environmentally friendly	synthesis of CQDs based on plasma - liquid interaction method. This is a	single-step method and does not use toxic chemicals. The size distribution	of obtained CQDs is rather uniform at approximately 3 nm. The emission peak	of CQDs shifts from 427 nm to 523 nm as the excitation	wavelength is varied from 340 nm to 460 nm. The non-equilibrium reactive	chemistry of plasma liquid interaction is responsible for acceleration of	the CQDs formation process.
Screening of hybridoma cell lines secreting monoclonal antibodies specific for staphylococcal enterotoxin B (SEB) derived from Staphylococcus aureus
Authors: Minh Nghiêm Ngọc , Thu Nguyễn Thị Hoài , Linh Phạm Thùy , Dương Thân Đức , Hằng Vũ Thị Thu , Phan Lê Văn 
Published: April 2018

Staphylococcus aureus (S. aureus) produces 11 types of toxins and more than 20 different Staphylococcal enterotoxins (SEs), including SEA to SEE, SEG to SER and SEU. Among them, enterotoxin type B (Staphylococcal enterotoxin B - SEB) is quite heat stable and causes gastrointestinal diseases in food poisoning. The symptoms of SEB intoxication begin with the onset of sudden fever, about 40oC to 41oC, chills, headache, muscle aches and dry cough. Some patients feel shortness of breath and chest pain. Although SEB is not considered lethal, high level of exposure can lead to shock and death. Therefore, a nontoxic SEB recombinant antigen was produced to immunize mice to create B lymphocytes. Myeloma cells were fused with the B lymphocytes to generate hybridoma lines. The screening of monoclonal antibodies for the SEB antigen was determined by ELISA and Western blot tests. This study demonstrates that an SEB recombinant antigen can immunize a response against SEB in BALB/c mice. The production of monoclonal antibodies will be used to make a rapid detection strip for SEB based on immunochromatography.
Development of an ELISA using the surface antigen one protein to detect for Streptococcus suis infection
Authors: Chiêu Trần Thị Bích , Hoa Võ Minh , Uyên Phan Nhã , Hùng Trần Mạnh , Châu Nguyễn Văn Vĩnh , Hoa Ngô Thị 
Published: April 2018

Streptococcus suis (S. suis) is one of the most important pathogens to cause acute bacterial meningitis in Viet Nam and other Asia countries including Thailand and Hongkong. We investigated the potential of using ELISA with the SAO protein as antigen to detect for S. suis specific sero positive. An SAO specific antibody collected from hyperimmunised rabbits was employed to develop the prototype ELISA. S. suis and other bacterial pathogens were used to validate the sensitivity and specificity of this method. This prototype ELISA was validated using serum samples collected from meningitis patients to evaluate its application in sero surveillance. The prototype ELISA protocol included a 0.1mg/well concentration of the cloned and purified SAO-M antigen; the primary antibody, anti SAO-M protein, and secondary antibody were used at the dilution of 1:500 and 1:10000, respectively. Rabbit antisera contained specific SAO-M antibody with 100% specificity and titer of >1:16000. Validating the prototype ELISA using serum samples collected from patients infected with S. suis and other common pathogens for bacterial meningitis in Vietnam showed the specificity of 95% and sensitivity of 90%. Our current results confirmed the initial success in developing the prototype ELISA in diagnosis for S. suis infections and the potential for its future application.
Co-expression of AGPS and AGPL genes encoded for AGPase from cassava to enhance starch accumulation in transgenic tobacco
Authors: Đoài Nguyễn Văn , Hồng Nguyễn Minh , Ngọc Lê Thu , Thơm Nguyễn Thị , Trọng Nguyễn Đình , Trang Vũ Huyền , Hường Nguyễn Thị Thuý , Vân Phạm Thị , Ngọc Phạm Bích 
Published: April 2018

The AGPase (ADP-Glucose pyrophosphorylase) is one of the ubiquitous enzymes catalyzing the first step in starch biosynthesis. It plays an important role in regulation and adjusts the speed of the entire cycle of glycogen biosynthesis in bacteria and starch in plants. In higher plants, it is a heterotetramer and tetrameric enzyme consisting two large subunits (AGPL) and two small subunits (AGPS) and encoded by two genes. In this paper, both AGPS and AGPL genes were sucessfully isolated from cassava varieties KM140 and deposited in Genbank with accession numbers KU243124 (AGPS) and KU243122 (AGPL), these two genes were fused with P2a and inserted into plant expression vector pBI121 under the control of 35S promoter. The efficient of this construct was tested in transgenic N. tabacum. The presence and expression of AGPS and AGPL in transgenic plants were confirmed by PCR and Western hybridization. The starch content was quantified by the Anthrone method. Transgenic plant analysis indicated that that two targeted genes were expressed simultaneously in several transgenic tobacco lines under the control of CaMV 35S promoter. The starch contents in 4 analyzed tobacco transgenic lines displays the increase 13-116% compared to WT plants. These results indicated that the co-expression of AGPS and AGPL is one of effective strategies for enhanced starch production in plant. These results can provide a foundation for developing other genetically modified crops to increase starch accumulation capacity.
Study of suitable media for laccase synthesis of basidiomycete fungi from Bidoup - Nuiba park and its reactive dye decolorization ability
Authors: Hiền Trần Thị Thu , Hiền Lê Thị , Huynh Nguyễn Văn , Hằng Đinh Thị Thu , Hà Đặng Thị Cẩm 
Published: April 2018

A fungal strain FBD154 with high laccase production was isolated from Bidoup-Nui Ba Parks, Lam Đong, Vietnam. FBD154 was identified as Polyporus sp. FBD154 based on traditional method and ITS sequence analysis. Polyporus sp. FBD154 synthesized laccase with high activity 74925 U/l on modified TSH1 (200 g/l containing potato extract, 1 g/l casein, 1 g/l rice bran, 5 g/l soybean meal, 10 g/l manose, 3 g/l NH4Cl, 0.3 mM CuSO4, pH 4). Crude laccase of Polyporus sp. FBD154 was applied to decolor several synthetic and commercial dyes. After 30 min, laccase from Polyporus sp. FBD154 could decolorize synthetic dyes at 100 mg/l concentration with efficiency of 60% acid red (NY1), 18% acid red 299 (NY7), 52% acid blue 281 (NY5) and 83% Remazol Brilliant Blue R (RBBR) without mediator. For commercial dyes at concentration of 100 mg/l, color removal efficiency reached to 62% megafix black CLS (CLS) and 72% everzol red LF2B (LF-2B) without mediator. Efficiency of synthetic dye removal by Polyporus sp. FBD154 crude laccase with 200 µM mediator obtained 90% RBBR with violuric acid (VIO) after 30 min; 80% NY5 with hydroxybenzotriazole (HBT) for 24 hours; 87% NY1 with acetosyringone (Ace) for 5 min; 92% NY7, 91% LF-2Band 73% CLS with syringaldehyde (Syr) for 5 min. The obtained evidences show that laccase was synthesized by Polyporus sp. FBD154 with high potential for application in wastewater treatment of textile plants in particular as well a sin detoxification of polycyclic aromatic compounds in general.
Study on the effect of radiation-degraded β-glucan on body weight gain and blood biochemical indexes in mice
Authors: Long Nguyễn Thành , Xô Dương Hoa , Luân Lê Quang 
Published: April 2018

The suspension solution containing 10% water-insoluble β-glucan extracted from yeast cell wall was irradiated by gamma rays from a Co-60 source for degradation. The water-soluble β-glucan products with molecular weight (Mw) of about 30.5, 24.9 and 10.8 kDa were successfully prepared from the samples irradiated at the doses of 100, 200 and 300 kGy, respectively. The obtained water-soluble β-glucan products were tested in mice for examination of their effect on the weight gain, feed conversation rate and blood chemistry indexes. The results after 4 weeks testing indicated that the oral supplementation of all water-soluble β-glucan samples prepared by gamma rays Co-60 irradiation method promoted the increase of body weight as well as the efficiency in converting the feed mass into the weight gain in the tested mice. In addition, β-glucan samples also reduded some contents of blood biochemistry indexes such as of glucose, urea, total protein, triglyceride and cholesterol in tested mice. The supplementation by 2 mg per mouse water-soluble β-glucan product with Mw ~ 24.9 kDa prepared by gamma irradiation at 200 kGy enhanced 16.1% the body weight and decresed 13.3% the feed conversation rate for the tested mice. The results on the blood biochemistry indexes also indicated that this β-glucan product reduced the contents of glucose, urea, total protein, triglyceride, and cholesterol in blood of tested mice by 27.1, 67.3, 56.0, 57.4 and 51.5%, respectively, compared to those in blood of the control ones. Thus, the low Mw and water-soluble β-glucan prepared by irradiation method can be applied as a potential material for production of the functional foods.
Removal of lead by sulfate-reducing bacteria in anaerobic continuous stirred tank reactors
Authors: Yên Nguyễn Thị , Hoa Kiều Thị Quỳnh 
Published: April 2018

Lead contaminated wastewater negatively impacts to living organisms as well as humans. In recent years, a highly promising biological process using the anaerobic production of sulfide ions by sulfate-reducing bacteria has presented itself as an alternative option for the removal of lead. This process is based on microbial utilization of electron donors, such as organic compounds (carbon sources), and sulfate as the terminal electron acceptor for sulfide production. The biogenic hydrogen sulfide reacts with dissolved heavy metals to form insoluble metal sulfide precipitates Removal of lead by an enriched consortium of sulfate-reducing bacteria (DM10) was evaluated sulfate reduction, sulfide production and lead precipitation. Four parallel anaerobic continuous stirred tank reactors (CSTR, V = 2L) (referred as R1 - R4) were fed with synthetic wastewater containing Pb2+ in the concentrations of 0, 100, 150 and 200 mg L-1 of lead and operated with a hydraulic retention time of 5 days for 40 days. The loading rates of each metal in R1- R4 were 0, 20, 30 and 40 mg L-1 d-1, respectively. The results showed that there was no inhibition of SRB growth and that lead removal efficiencies of 99-100% for Pb2+ were achieved in R2 (100 mg L-1) and R3 (150 mg L-1) throughout the experiment. For the highest lead concentration of 200 mg L-1, a decrease in efficiency of removal (from 100 to 96%) was observed at the end of the experiment. The obtained result of this study might help for a better control operation and performance improvements of reactors.
BIODIVERSITY AND DISTRIBUTION PATTERNS OF FREE-LIVING NEMATODES COMMUNITIES IN BALAI RIVER, BENTRE PROVINCE
Authors: Thai Tran Thanh , Lam Nguyen Le Que , Yen Nguyen Thi My , Quang Ngo Xuan , Vanreusel Ann 
Published: April 2018

Nematodes communities in Ba Lai river, Ben Tre province were investigated in September of 2015 (eight stations from estuary to upstream). The results showed that the nematodes communities have characterized by high density and biodiversity, providing useful information of nematodes assemblages in freshwater habitas, in particular inland river. Also the results indicated that the distribution of nematodes communities in Ba Lai river was strongly discriminated between in and outside of dam with two groups. The Ba Lai dam may be reasons for cause the nematodes distribution discontinuity. Present study is a pioneering attempt to record the impact of the dam on benthic-invertebrate in Vietnam.
Genomic Profiling of HER2-Positive Gastric Cancer: PI3K/Akt/mTOR Pathway as Predictor of Outcomes in HER2-Positive Advanced Gastric Cancer Treated with Trastuzumab
Authors: Díaz-Serrano Asunción , Angulo Barbara , Dominguez Carolina , Pazo-Cid Roberto , Salud Antonieta , Jiménez-Fonseca Paula , Leon Ana , Galan Maria Carmen , Alsina Maria , Rivera Fernando , Plaza J. Carlos , Paz-Ares Luis , Lopez-Rios Fernando , Gómez-Martín Carlos 
Published: April 2018

Abstract

Background
HER2-positive gastric cancer (GC) affects 7%–34% of patients with GC. Trastuzumab-based first-line treatment has become the standard of care for HER2-positive advanced gastric cancer (AGC). However, there are no clinically validated biomarkers for resistance to HER2-targeted therapies. Upregulation of PI3K pathway and tyrosine kinase receptor (TKR) alterations have been noted as molecular mechanisms of resistance in breast cancer. Our study aimed to perform a molecular characterization of HER2-positive AGC and investigate the role of PI3K/Akt/mTOR signaling pathway activation and TKR gene copy number (GCN) gains as predictive biomarkers in HER2-positive AGC treated with trastuzumab.

Patients and Methods
Forty-two HER2-positive GC samples from patients treated with trastuzumab-based first-line chemotherapy were selected. DNA samples were sequenced. PTEN and MET immunohistochemistry were also performed.

Results
Concurrent genetic alterations were detected in 97.1% of HER2-positive AGC. We found activation of PI3K/Akt/mTOR pathway in 52.4% of patients and TKR GCN gains in 38.1%. TKR GCN gains did not correlate with overall survival (OS) or progression-free survival (PFS). Multivariate Cox models showed that PI3K/Akt/mTOR activation negatively affects the effectiveness of trastuzumab-based chemotherapy in terms of OS and PFS.

Conclusion
Our results provide for the first time a detailed molecular profile of concurrent genetic alterations in HER2-positive AGC. PI3K pathway activation could be used as a predictive marker of worse outcome in this patient population. In addition, gains in copy number of other TKR genes in this subgroup may also influence the survival benefit obtained with trastuzumab.

Implications for Practice
This article reports, for the first time, a detailed molecular profile of genomic alterations in patients with HER2-positive advanced gastric cancer (AGC). PI3K/Akt/mTOR signaling pathway activation seems to have a differentially negative effect on overall survival and progression-free survival in AGC treated with trastuzumab-based chemotherapy. Combining different targeted agents could be a successful therapeutic strategy to improve the prognosis of HER2-positive AGC.
Evaluating a New Writing Material: Students’ Perception towards the Use of a Teacher-made Coursebook
Authors: Akil Mansur , Hamra Arifuddin , Atmowardoyo Haryanto , Tjalla Magdahalena 
Published: April 2018

This study discusses an evaluation of a teacher-made coursebook for teaching essay writing course. Forty students were asked to give their perception of the use of the coursebook in terms of goal, contents, organization and design, and methodology. The analysis of the students’ answers showed that their perception towards the coursebook was positive. The majority of the students said that the coursebook objective was relevant to their needs, the contents were complete, the topics were interesting and were relevant to their needs and interests as well as their sociocultural background, the explanation was easy to be understood, the tasks and activities were attracting and helped them expressed their knowledge, experiences, and interests in a variety of essay types. Similarly, the coursebook was well-arranged from unit to the subunit. Students also said that the methodology used by the coursebook helped them expressed their knowledge, experiences, and interests accurately and fluently.
Arşiv ve Hatırat Kayıtlarına Göre Muallim Necati Bey’in Savaş Fotoğrafçısı Olarak Görevlendirilmesi ve Diğer Fotoğrafçılık Faaliyetleri
Authors: MARTTİN Volkan 
Published: April 2018

Bu çalışmanın ana gündemini Osmanlı
Devleti’nin Maarif-i Umumiye Nezareti’nde “fotoğraf muallimi” olan Necati
Bey’in, Çanakkale Kara Muharebelerini fotoğraf/sinema şeklinde filme alma;
muharebe alanlarının ve vazife başındaki askerlerin fotoğraflarını çekme
amacıyla “savaş fotoğrafçısı” olarak cepheye gönderilmesi oluşturmaktadır. Öncelikle, fotoğrafın tarihçesi
ekseninde ele alınan konuda, fotoğrafın Osmanlı Devleti’ndeki “hüsn-i kabûl”üne
değinilmiştir. Daha sonra, Çanakkale Muharebelerinin nesiller için bir terbiye
kaynağı olduğu hemen anlaşılmış; Çanakkale Zaferi’nin bir “mefkûre bayramı”
olarak idrak edilmesi düşüncesi öne çıkmıştır. Çanakkale’deki kahramanların ve cephe
manzaralarının kaydedilerek gelecek nesillere ulaştırılması gibi ulvî bir vazife
üstlenen Necati Bey’in faaliyetleri Başbakanlık Osmanlı Arşivi’nde mahfuz
belgeler esas alınarak işlenmiştir. Fotoğrafçılık ve sinemaya ilişkin yapılan
çalışmalar ile savaşın tanıklarının hatıraları arşiv belgeleriyle
karşılaştırılarak kullanılmıştır.

Necati Bey’in Çanakkale’den sonraki
fotoğrafçılık faaliyetleri Osmanlı arşiv belgeleri ışığında işlenmiştir.
A novel and widely accessible HPLC method for determination content of homosalate in sunscreen products on the market
Authors: Imamovic Belma , Bešić Zinajda , Bečić Ervina 
Published: April 2018

Introduction: Considering that the research has shown that homosalate act as endocrine-active substance, it is very important to develop quick and sensitive method for tracking its concentrations in sunscreen products. The aim of this paper is to develop and validate the method for determining homosalate in sunscreen preparations and controlling the content of the products found on the market of Bosnia and Herzegovina.
Methods: A high pressure liquid chromatography (HPLC) method for determination homosalate in sunscreen products has been developed and validated. Samples of six different manufacturers have been analyzed. HPLC method is method of choice for this type of investigation.
Results: According to the calibration curve it has been found that the proposed analytical method in a given range of concentration is linear and that the correlation coefficient is R2=0.9998. Accuracy of the method is in range 94.26% -121.53%.The results have shown that the homosalate concentration in the tested samples did not exceed the maximally permissible concentration (10%). In the sample AV50 homosalate was not declared as an active ingredient, but it was identified and quantified at a concentration of 0.143%.
Conclusion: Results of investigation of cosmetic products that are widely present on the market show the need of developing a sufficiently sensitive, easily accessible, analytical method for controlling the content of organic UV filters since the exceeding of the maximally permissible concentration can have a harmful effect on people who use these kinds of products. The results show that developed method meets conditions and is suitable for wide application.
Kundalini Yoga for Generalized Anxiety Disorder: An Exploration of Treatment Efficacy and Possible Mechanisms
Authors: Gabriel M. G. , Curtiss Joshua , Hofmann Stefan G. , Khalsa Sat Bir S. 
Published: April 2018

Abstract
The aim of this study was to examine the efficacy of Kundalini Yoga in reducing symptoms of generalized anxiety disorder (GAD) compared to a common treatment-as-usual condition using cognitive techniques. A secondary objective was to explore potential treatment mechanisms. Females aged 24 to 75 years with GAD (n = 49) received either an 8-week Kundalini Yoga intervention (n = 34) or an 8-week treatment-as-usual condition (n = 15). The yoga condition resulted in lower levels of anxiety relative to the treatment-as-usual condition. Furthermore, changes in somatic symptoms mediated treatment outcome for Kundalini Yoga. Kundalini Yoga may show promise as a treatment for GAD, and this treatment might convey its effect on symptom severity by reducing somatic symptoms.
Bone versus cartilage ossiculoplasty: a case series
Authors: Rout Manas Ranjan , Mohanty Deeganta , Das Pakeer 
Published: April 2018

<p class="abstract"><strong>Background:</strong> Ossiculoplasty can be done by using both autologous bone and cartilage. Few literature shows cartilage is better and few shows bone is better. This study has been done to compare the both type of ossiculoplasty and find out the better one by comparing the hearing results.</p><p class="abstract"><strong>Methods:</strong> Present study is a retrospective study with 6 years data collected from the inpatient’s records. It was conducted in the department of ENT, in a tertiary care hospital of South India. Total number patients studied were 200. Patients with chronic ear disease having ossicular chain defects were evaluated for study. Two types of ossiculoplasty were performed (malleus-stapes assembly and membrane to stapes head interposition) using both cartilage and bone (each 100 patients). Postoperatively hearing result was evaluated at 1month, 6 months and 1 year and statistical analysis was done using z’ test. </p><p class="abstract"><strong>Results:</strong> Hearing improvement was better with bone ossiculoplasty then cartilage type. Average hearing gain was 33.34dB in bone where as in cartilage it is 29.34 dB. Average improvement in air bone gap is 21dB in bone type, whereas 19dB in cartilage type. But when we applied z’ test, it showed z’ value as 1.4506 indicating insignificant (z’ value should be &gt;1.96).</p><p class="abstract"><strong>Conclusions:</strong> Study shows that, clinically bone ossiculoplasty is superior to cartilage in terms of hearing improvement. But it is statistically not significant.</p>