bluuebunny/crossref_metadata_2025_split huggingface dataset:
STRATEJİK MALİYET YÖNETİMİ- BİST’E KOTE İMALAT İŞLETMESİ ÜZERİNE ARAŞTIRMA
Authors: TÜNEL Rabia Kübra , GÜLENÇER İlker 
Published: July 2018

Küreselleşmenin,
geliştirilen yeni teknolojilerin, artan müşteri ihtiyaçlarının, rekabetin ve
hızlı bir değişimin olduğu günümüzün iş dünyasında işletmelerin başarıya ulaşma
olanakları oldukça zor hale gelmiştir.
Dünyadaki değişimlerden çok hızlı etkilenen sanayi işletmelerinde de
başarıya erişme fırsatı giderek azalmaktadır. Günümüz ortamında sanayi
sektöründe yaşanılan rekabet giderek hızlanmaktadır. İmalat sektörü; sağladığı
istihdam olanakları, tedarikçi işletmelere olan katkısı ve başka sektörlere
kattığı değer nedeni ile ülke ekonomisinde çok önemli yere sahiptir. Günümüz
ekonomisinde, pazar olanaklarından yararlanabilmek ve rekabet koşullarına uyum
sağlayabilmek adına maliyetlerin daha iyi yönetilmesi büyük önem arz
etmektedir. Bu çalışmanın amacı, artan rekabet ve müşteri isteklerinin daha
önemli hale geldiği ortamda sanayi işletmelerinin kârlılıklarını stratejik
maliyet yönetimi kapsamında incelemektir. Çalışmada stratejik maliyet yönetimi
ile yaklaşımları incelenmiş olup, stratejik maliyet yönetim yaklaşımlarından
Toplam Kalite Yönetimi sistemlerinin kârlılığa etkisi gösterilmiştir.
Pattern of internet addiction among urban and rural school students, Mangaluru, India: a comparative cross-sectional study
Authors: A. Sowndarya T. , Pattar Mounesh 
Published: July 2018

Background: Adolescents use the Internet for a variety of activities besides gaming; they frequently engage themselves with social networking, instant messaging, blogging and downloading information. Heavy Internet use has been associated with potential side effects, such as loss of control over the use of the Internet, adverse effects on other daily activities, emotional status and communication among family members. Objective of present study to assess the prevalence of Internet Addiction (IA) and factors associated with Internet use among Urban and Rural school students.Methods: A school based cross sectional study was conducted in the urban and rural field practice area of a medical college hospital in Mangaluru. Internet addiction was assessed using Young’s Internet Addiction Test.Results: The prevalence of internet addiction among urban school students was found to be i.e. 83.3%, while it was 78% in rural school students. Mild IA was common among both. Male gender, smart phones and hours spent on internet were common risk factor for IA in both groups.Conclusions: Young’s Internet Addiction Test (IAT) is a simple and easy tool to assess Internet addiction among adolescent school students. Need to give importance of outdoor activity and community level education needed to prevent Internet Addiction.
Biofilm production and its correlation with antibiotic resistance pattern among clinical isolates of Pseudomonas aeruginosa in a tertiary care hospital in north-east India
Authors: Saha Swarnatrisha , Devi Ksh Mamta , Damrolien Shan , Devi Kh. Sulochana , . Krossnunpuii , Sharma Kongbrailatpam Tharbendra 
Published: July 2018

Background: Pseudomonas aeruginosa is an ubiquitous pathogen capable of surviving in a variety of environmental conditions. It is increasingly gaining importance as a multidrug resistant nosocomial pathogen. Biofilm acts as a barrier, reducing the penetration of these drugs and consequently, preventing them from exercising their actions. The aim of this study is to isolate and identify Pseudomonas aeruginosa from various clinical specimen and to find out their production of biofilms and their correlation with antibiotic susceptibility pattern.Methods: All Pseudomonas aeruginosa over a period of 1 year were isolated and identified from clinical specimens and antibiotic susceptibility test was done following standard operative procedures. Biofilm detection was done by Congo Red Agar method (CRA).Results: 134 isolates of Pseudomonas aeruginosa was isolated. Maximum isolates were isolated from sputum samples 55 (41%) and most were from wards 68 (51%) giving a probability of increased healthcare associated infections. Biofilm production by the isolates was seen in 39 (29%). All the biofilm producing isolates shows more resistant pattern in comparison to non-biofilm producers. 69% of Imipenem and 82% of Meropenem resistant isolates produce biofilm. All the P. aeruginosa including MDR and biofilm forming strains were sensitive to Colistin.Conclusions: Resistance to antimicrobial agents is the most important feature of biofilm infections. Ability of P. aeruginosa to form biofilms renders antibiotic treatments inefficient and therefore promotes chronic infectious diseases. As a result, infections caused by bacterial biofilms are persistent and very difficult to eradicate.
A study on prevalence of rotavirus infection in children below 5 years, with acute gastroenteritis
Authors: Manick Dass S. , Pattnaik Snigdha , Amulya K. 
Published: July 2018

Background: Diarrheal diseases are among the most frequent causes of morbidity and mortality in children worldwide, especially in India. This cross sectional study was conducted to investigate the causative agent of diarrhea among children, below five years, treated at an urban tertiary care hospital, Telangana.Methods: Stool specimens were collected from 240 children under 5 years of age visiting Apollo Medical College, General Hospital in Hyderabad, hospitals due to acute diarrhea. Rapid stool antigen immunochromatograhic testing was used to diagnose rota virus diarrhea. In this test the VP 6 antigen present on the middle layer of the virus capsule is detected.Results: During the 2 months of the study period, 60 children visited the institute seeking treatment of diarrhoea. 11 (18%) of, the children were found to be positive for rota virus infection. It was also observed that, due to advent of rotavirus vaccine, incidence of diarrhea has come down.Conclusions: In our study the prevalence of rotavirus infection in children suffering from acute gastroenteritis below five years of age is 18.3%. This study is performed using an ICT rapid card test in which group A of the rotavirus is detected, the drawback of this study is other groups of rotavirus like B and C which also cause human infections are not detected. Following the rapid ICT card test which is a diagnostic test, ELISA, confirmatory test for the detection of rotavirus should also be done.
Wheat leaf epidermal pattern as a model for studying the influence of stress conditions on morphogenesis
Authors: Zubairova U. S. , Doroshkov A. V. 
Published: July 2018

The leaf epidermis of a monocotyledonous plant is a widely used model system for studying the differentiation of plant cells, as it contains readily observable specialized cells. The approach proposed in this paper uses a growing cereal leaf to study stress-induced dynamic changes in morphogenesis. In the process of formation, the linear leaf of wheat remains in the stationary growth phase for long. This fact permits us to observe a series of successive morphogenetic events recorded in the cellular structure of the mature leaf. In studying the cellular architecture of the wheat leaf epidermis, we obtained and processed confocal 3D images of wheat leaves stained with fluorescent dyes. This procedure allows an accurate morphometric description and determination of quantitative characteristics of the leaf epidermal pattern. Low temperatures are among the factors limiting the growing of crop plants in the temperate zone. In the present work, we show significant aberrations of stomatal morphogenesis in the epidermis of boot leaves of wheat varieties Saratovskaya 29 and Yanetskis Probat in response to cold stress. We found that nonfunctional stomata predominated in the zone of maximum manifestation of stress, whereas in the zones formed before and after the stress impact, the developmental anomalies come to the disturbance in the morphogenesis of subsidiary cells. In Saratovskaya 29, a significant amount of ectopic trichomes formed in rows predetermined to stoma formation. The proposed approach can provide standardized qualitative and quantitative data on stressinduced morphogenesis aberrations in wheat leaf epidermis. Subsequently, these data can be used for verification of computer models of leaf morphogenesis. Further study of the mechanisms of the effect of cold stress on morphogenesis will add to the search for additional opportunities to increase wheat yields in areas of risky agriculture.
Retention Mechanism of Proteins in Hydroxyapatite Chromatography – Multimodal Interaction Based Protein Separations: A Model Study
Authors: Itoh Daisuke , Yoshimoto Noriko , Yamamoto Shuichi 
Published: July 2018

Background:Retention mechanism of proteins in hydroxyapatite chromatography (HAC) was investigated by linear gradient elution experiments (LGE).Materials and Methods:Several mobile phase (buffer) solution strategies and solutes were evaluated in order to probe the relative contributions of two adsorption sites of hydroxyapatite (HA) particles, C-site due to Ca (metal affinity) and P-site due to PO4 (cation-exchange). When P-site was blocked, two basic proteins, lysozyme (Lys) and ribonuclease A(RNase), were not retained whereas cytochrome C(Cyt C) and lactoferrin (LF) were retained and also retention of acidic proteins became stronger as the repulsion due to P-site was eliminated. The number of the binding site B values determined from LGE also increased, which also showed reduction of repulsion forces.Conclusion:The selectivity (retention) of four basic proteins (RNase, Lys, Cyt C, LF) in HAC was different from that in ion-exchange chromatography. Moreover, it was possible to tune the selectivity by using NaCl gradient.
The Role of Ortho-dearomatization Reaction in Constructing Spirocyclic Scaffolds with an All-carbon Ring Junction
Authors: Shi Lili , Zhang Wenge , Chen Shou , Lu Lele , Fan Rong , Tan Jiajing , Zheng Chao 
Published: July 2018

Background:
Spiro skeleton is an important structural motif in natural products, usually accounting
for their formidable architectures and remarkable biological profiles. Recent advances demonstrated that a diverse
range of scenarios held the promise for the assembly of spirocenter based on ortho-dearomatization strategy.
In this article, we describe the latest development of ortho-dearomatization reaction in constructing spirocyclic
scaffolds with an all-carbon ring junction from a methodological standpoint.

Objective:
The review focuses on recent progress in the area of ortho-dearomatization reaction in constructing
spirocyclic scaffolds with an all-carbon ring junction.

Conclusion:
In summary, we have summarized the capability of ortho-dearomatization reaction to construct
spirocyclic skeleton, a common structural pattern found at the core of numerous natural products with broad
structural diversities and important bioactivities. Success in this area will benefit not only the area of synthetic
chemistry through methodological development, but also medicinal chemistry and chemical biology by providing
access to rapid assembly of bioactive compounds’ core scaffolds.
In vitro Activity of the Novel Pyrimidines and Their Condensed Derivatives Against Poliovirus
Authors: Solomyannyi Roman , Slivchuk Sergii , Smee Donald , Choi Jung-ae , Rusanov Eduard , Zhirnov Victor , Brovarets Volodymyr 
Published: July 2018

Background:
Substituted pyrimidine derivatives (non-nucleoside) are found to be associated
with various biological activities. The various substituted pyrimidines are also having significant in vitro
activity against different DNA and RNA viruses. The present study focuses on the anti-PV activity of
new pyrimidines and their condensed derivatives.

Methods:
A series of novel pyrimidines and their condensed derivatives were synthesized and their
structures were confirmed by spectral data. Their antiviral activities against poliovirus type 3 (PV-3)
were evaluated in vitro. In cell culture, morphological changes observed in cells infected with polioviruses,
including cell rounding and detachment from the substrate, are generally termed cytopathic
effects (CPE). The effects of synthetic pyrimidines on PV amplification in a culture of the heteroploid
cell line, Vero 76 (African green monkey kidney cells) were investigated.

Results:
Bioassays in vitro showed that one of seven synthesized compounds, 7-(Benzenesulfonyl)-5-
benzyl-N-(prop-2-en-1-yl)-5H-pyrrolo[3,2-d]pyrimidin-4-amine, has potent antiviral activity against
PV-3 (EC50 = 0.75 μM). The selectivity index of this compound is similar to that of pirodavir.

Conclusion:
The need for antiviral agents to treat PV-associated diseases remains great, but few options
currently exist. Here we show that substituted pyrimidine derivatives are a promising structure class of
chemical compounds for the development of antiviral drugs against PV infections.
Synthesis, Antitubercular Activity, Molecular Modeling and Docking Studies of Novel Thiazolidin-4-One Linked Dinitrobenzamide Derivatives
Authors: Singh Karanveer , Sinha Manish , Kuletha Shruti , Kaur Baljeet , Kaur Amandeep , Tripathi Dinesh K. , Srivastava Kishore K. , Murugesan Vanangamudi , Srikala Rajala , Chaudhary Amrendra K. 
Published: July 2018

Background:
Tuberculosis is a catastrophe sprawled across the world. The World Health
Organization Global Tuberculosis Report 2017 inferred that there were an estimated 10.4 million people
suffered from tuberculosis including 490000 Multidrug-Resistant TB (MDR-TB) cases. Several new
lead molecules like dinitrobenzamide derivatives were found to be highly active against multidrugresistant
strains of M. tuberculosis. To further explore the pharmacophoric space around the
dinitobenzamide moiety, a series of compounds have been synthesized by linking it with the thiazolidin-
4-one. The presented work is an effort to study the biological effect of thiazolidin-4-one scaffold on
dinitrobenzamide derivatives as antitubercular agents. A molecular modeling study was also performed
on the synthesized molecules to reveal the requirements for further lead optimization.

Methods:
The thiazolidin-4-one linked 3,5-dinitrobenzamide derivatives have been synthesized by onepot
three-component condensation reaction of an amine, substituted aldehydes and thioglycolic acid in
presence of N, N'-Dicyclohexylcarbodiimide (DCC). These compounds were evaluated against Mycobacterium
tuberculosis H37Ra. A pharmacophore modeling approach has been used in order to explore
the collection of possible pharmacophore queries of thiazolidin-4-one linked 3, 5-dinitrobenzamide
derivatives against M. tuberculosis. The synthesized compounds were docked on to the M. tuberculosis
DprE1 enzyme to identify the structural features requirement of these analogs against this potential target
of M. tuberculosis.

Results:
The synthesized compounds showed the antitubercular activity in the range of 6.25-50 μg/ml.
The pharmacophore modeling suggests that the presence of aromatic moiety, thiazolidin-4-one ring and one of
the nitro groups are significant for inhibiting the enzymatic activity. While docking studies showed that hydrophobic
and hydrogen bond interactions of the aromatic moiety and nitro group crucial to inactivate the
DprE1 enzyme.

Conclusion:
The study showed that the linking of thiazolidin-4-one with dinitrobenzamide leads to
compounds active against M. tuberculosis. These findings also suggested that further lead optimization
would be carried out by focusing on the aromatic system along with electron-rich substituents placed on
the thiazolidin-4-one for making better hydrophobic and hydrogen bond interactions with the DprE1
target.
Hypovitaminosis D in Healthy Pregnant Women and their Newborns in Greece
Authors: Sideri Vasiliki , Antonakos George , Fretzayas Andreas , Attilakos Achilleas , Chrelias Charalambos , Papaevangelou Vasiliki , Nicolaidou Polyxeni , Papadopoulou Anna 
Published: July 2018

Background/Objectives: The aim of this work was to evaluate the current vitamin D status in healthy pregnant women and their newborns living in Greece and assess possible associations between 25(OH)D and anthropometric features of their fetuses and newborns. </P><P> Materials & Methods: 81 healthy women were monitored during pregnancy. Biochemical markers related to bone metabolism, 25(OH)D and PTH levels were measured in serum samples of mothernewborn pairs at 1st trimester of pregnancy and at delivery in mothers, in cord blood and at the 3rd day of life of newborns.Results:Maternal 25(OH)D levels at the 1st trimester of pregnancy (22.6±9.2ng/ml) were significantly higher than those at delivery (19.2±9.2ng/ml) (p<0.001). Furthermore, umbilical 25(OH)D levels (21.3±9.3ng/ml) were higher than maternal at delivery (p=0.005) and neonatal levels (19.4±10.4 ng/ml) (p=0.021). Only 57.3% of the mothers at the first trimester and 46.7% at delivery as well as 55.8% of the fetuses and 38.5% of the neonates had adequate vitamin D levels (25(OH)D≥30ng/ml). A significant positive correlation was found between fetal femur length at the 22nd week of gestation and maternal 25(ΟΗ)D at the 1st trimester of pregnancy (r=0.36, p=0.048) while body length was significantly higher in newborns whose mothers had sufficient 25(OH)D levels (51.5±2.1cm) compared with those whose mothers had insufficient or deficient 25(OH)D levels at delivery (50.6±2.0cm) (p=0.047).Conclusion:The study confirms inadequate levels of vitamin D in pregnant women in Greece associated with inadequate vitamin D levels of their fetuses and newborns.
BANGUNAN PERKEBUNAN TEH ZAMAN BELANDA DI JAWA BARAT: KAJIAN ARKEOLOGI PUBLIK
Authors: Nuralia Lia 
Published: July 2018

Tulisan ini bertujuan mempublikasikan bangunan industri perkebunan peninggalan zaman Belanda, yang diduga sebagai bangunan dan situs cagar budaya. Metode penelitian desk research terhadap laporan hasil penelitian arkeologi, buku, artikel jurnal, dan lain sebagainya. Kemudian dilakukan pembaruan gambar dan peta yang terkait dengan contoh bangunan yang dikemukakan. Pada saat penelitian dilakukan di tahun 2009, 2019, dan 2011, digunakan metode penelitian arkeologi dengan teknis pengumpulan data studi pustaka, survey permukaan, dan wawancara. Pembahasan dilakukan terhadap bangunan dan lingkungan perkebunan (kawasan emplasemen, situs, struktur) yang diduga sebagai Cagar Budaya industri perkebunan zaman Belanda. Hasil yang diperoleh adalah terdapat empat cara arkeologi publik warisan industri perkebunan zaman Belanda, yaitu (1) museum alam dan laboratorium alam, (2) agrowisata dan destinasi wisata, (3) penerbitan, dan (4) sosialisasi hasil penelitian.Kata Kunci: Bangunan industri perkebunan, arkeologi publicAbstractThis paper aims to publicize the plantation industry building of the Dutch era, which is suspected as a building and cultural heritage site. Research method is desk research to report of archeology research, book, journal article, and so forth. Image updates and maps related to the example of the proposed building are then updated. At the time of the research conducted in 2009, 2019, and 2011, used the method of archaeological research with technical data collection literature study, surface survey, and interviews. The analysis was conducted on the plantation environment and building (emplacement area, site, structure) which is suspected as the Cultural Heritage of plantation industry at the Dutch era. The results obtained are four public archaeological method to the cultural heritage of plantation industry, namely (1) natural museums and natural laboratories, (2) agro-tourism and tourism destinations, (3) publications, and (4) socialization of research resultsKey words: Plantation industry building, public archeology
Technology transfer from British to Vietnamese industrial companies - venturing into a new business culture
Authors: Tran Ngoc Ca 
Published: July 2018

The paper examines the process of technology transfer from British industrial companies to Vietnamese companies, to look at the obstacles of this process, especially in dealing with different business culture environments. The study uses the case studies method, conducting interviews with about ten companies working in oil and gas service industry. Since this is only a first stage of the longer term project, only preliminary results were discussed. Therefore, a company in civil engineering consulting has been examined for comparison. The paper argues that the differences in perception of the same operation activity like service in oil and gas industry are crucial factors to take into account if the transfer process is to be successful. Also, the transferor and the recipient may have different behaviour in negotiating, in communicating with each other. Thus, the preparation of background information, to do "home work", patience and pro-active attitudes in trying to understand partners are important for transferring technology into different business environment.

In addition, the factors, sometime not very technology-related, such as internal political motives and organisational issues of the firms involved can be very influential in the success of technology transfer process.
Perancangan Prototipe Sistem Kontrol Suhu dan Kelembaban pada Gedung Walet dengan Mikrokontroler Berbasis Mobile
Authors: Dewi Suti Kurnia , Nyoto Rudy Dwi , Marindani Elang Derdian 
Published: July 2018

Abstrak— Sarang burung walet merupakan salah satu komoditas ekspor yang memiliki nilai ekonomis cukup tinggi. Suhu dan kelembaban di dalam gedung walet sangat berpengaruh terhadap kualitas dan harga sarang burung walet. Penelitian ini membangun prototipe sistem kontrol suhu dan kelembaban pada gedung walet dengan mikrokontroler berbasis mobile. Mikrokontroler berfungsi untuk mengambil data suhu, kelembaban dan kualitas udara kemudian mengirimkannya ke server sehingga pengguna dapat memantau dan mengatur suhu serta kelembaban di dalam gedung walet melalui aplikasi android maupun website sistem. Penelitian ini menggunakan mikrokontroler Wemos D1 Mini, sensor suhu dan kelembaban DHT11, sensor kualitas udara MQ135, water pump sebagai supplier air dan exhaust fan sebagai sirkulator udara. Pengujian yang dilakukan terhadap sistem terdiri dari pengujian hardware dan software. Pada pengujian hardware, rangkaian mikrokontroler membutuhkan waktu rata-rata 11 detik untuk mengirimkan data ke server. Sedangkan pada pengujian software, rangkaian mikrokontroler membutuhkan waktu rata-rata 3 detik untuk merespon perintah dari perangkat android dan 5 detik untuk perintah dari website sistem. Berdasarkan hasil perngujian dapat disimpulkan bahwa rancangan prototipe sistem kontrol suhu dan kelembaban pada gedung walet dapat berfungsi dengan baik. Kata kunci— Sarang Burung Walet, Mikrokontroler, Wemos D1 Mini, DHT11, MQ135, Suhu, Kelembaban.
Prediksi Kecepatan Angin Menggunakan Adaptive Neuro Fuzzy (ANFIS) dan Radial Basis Function Neural Network (RBFNN)
Authors: Nikentari Nerfita , Bettiza Martaleli , Sastypratiwi Helen 
Published: July 2018

Angin sebagai salah satu fenomena alam yang mempengaruhi berbagai aspek dalam kehidupan manusia baik pengaruh positif maupun negatif. Aspek ini berperan besar dalam ekonomi, pariwisata, pembangunan, transportasi maupun perdagangan masyarakat. Data angin dalam hal ini kecepatan angin belum dapat diketahui secara pasti nilainya oleh karena itu perlu adanya prediksi. Adaptive Neuro Fuzzy Inference System (ANFIS) dan Radial Basis Function Neural Networkc(RBFNN) adalah algoritma yang dapat digunakan untuk prediksi data. Penelitian ini menggunakan ANFIS dan RBFNN untuk memprediksi kecepatan angin. Data prediksi yang digunakan dalam penelitian ini adalah data time series. Data kecepatan angin diperoleh dari BMKG (Badan Meteorologi Klimatogi dan Geofisika) Tanjungpinang, Kepualuan Riau. Hasil prediksi dengan kedua metode ini dibandingan dengan data asli untuk mengetahui metode mana yang lebih akurat dalam prediksi data. Hasil pengujian menggunakan kedua algoritma memperlihatkan akurasi terbaik (paling mendekati data asli/target) diperoleh oleh RBFNN yaitu dengan nilai RMSE adalah 0,1766 dan hasil RMSE ANFIS adalah 1,1456.