bluuebunny/crossref_metadata_2025_split huggingface dataset:
Relationship between the positions of cytoplasmic granulation and the oocytes developmental potential in human
Authors: Yi Xiao-fang , Xi Hong-Lin , Zhang Si-Lin , Yang Jing 
Published: May 2019

AbstractTo evaluate the relationship between the positions of cytoplasmic granulation and the oocytes developmental potential in human, we detected the developmental potentials of oocytes with centrally located cytoplasmic granulation (CLCG). The patients’ age, body mass index (BMI), Infertility duration, follicle stimulation hormone (FSH) levels, average stimulate ovulation days, gonadotropin (GN) total dose, fertilization rate, cleavage rate, high quality embryo rate, embryo utilization rate and pregnancy rate were analyzed. The results showed that there were no significant difference on patients’ age, BMI, infertility duration, FSH levels, average stimulate ovulation days, GN total dose, pregnancy rate and birth rate between CLCG group and control group in patients with BMI < 24 (P > 0.05). However, there was no significant difference in fertilization rate, cleavage rate, and high quality embryo rate in patients with BMI < 24 (P > 0.05). The pregnancy rate was low in both groups, but 35 and 15 healthy fetuses were born in each group. We also found that the central granulated area size did not affect fertilization rate, cleavage rate, embryo utilization rate, and high quality embryo rate (P > 0.05). These results suggested CLCG might be a normal morphology of oocyte. The oocytes from patients with or without CLCG had no significant difference in their developmental potentials. The patients who transferred CLCG embryos had successful delivery. The developmental potentials of oocytes with different CLCG grades had no obvious differences.
Evaluation of myocardial injury induced by different ablation approaches (radiofrequency ablation versus cryoablation) in atrial flutter patients: a meta-analysis
Authors: Zeng Qing , Li XingSan , Xu Ge 
Published: May 2019

Abstract
Background: To evaluate myocardial injury in Atrial flutter (AFL) patients undergoing Radiofrequency ablation (RF) and cryoablation (CRYO) treatments.
Methods: We conducted a systematic search on PubMed, Embase, Cochrane Library, and CBM databases. All relevant clinical trials (up to October 2018) on myocardial injury in AFL patients were retrieved and subsequent results analyzed with a random-effects model or a fixed-effects model.
Results: A total of eight clinical trials with a sample size of 644 patients, were identified and incorporated in the present study. The results indicated no significant differences in creatine kinase (CK) levels (mean difference (MD) = 62.74, P=0.46; 4–6 h and MD = 30.73, P=0.49; 12–24 h after ablation), creatine kinase MB(CK-MB) levels (MD = 17.32, P=0.25; 12–24 h post-ablation), troponinI (TnI) levels (MD = 0.12, P=0.08; 6 h after ablation), and troponin T (TnT) levels (MD = 0.30, P=0.08; 4–6 h post-ablation) between the two treatment approaches. However, patients receiving CRYO xhibited higher levels of CK (MD = 179.54, P=0.04; tested immediately after the procedure), CK-MB (MD = 10.08, P=0.004) 4–6 h after ablation, and TnT (MD = 0.19, P=0.002) tested the next morning. Moreover, those patients had a significantly reduced pain perception (odds ratio (OR) = 0.05, P=0.04) compared with those in the RF group.
Conclusion: These results indicate that CRYO in comparison with RF significantly increases myocardial injury in AFL patients. Additionally, it decreases pain perception during the procedure. Further large-sampled studies are needed to support these findings.
Mucin O-glycosylating enzyme GALNT2 facilitates the malignant character of glioma by activating the EGFR/PI3K/Akt/mTOR axis
Authors: Sun Zhongzheng , Xue Hao , Wei Yan , Wang Chaochao , Yu Rui , Wang Chengwei , Wang Shaobo , Xu Jianye , Qian Mingyu , Meng Qinghu , Li Gang 
Published: May 2019

Abstract
N-Acetylgalactosaminyltransferase 2 (GALNT2), the enzyme that regulates the initial step of mucin O-glycosylation, has been reported to play a role in influencing the malignancy of various cancers. However, the mechanism through which it influences gliomas is still unknown. In the current study, the Cox proportional hazards model was used to select genes. Data obtained from The Cancer Genome Atlas (TCGA) database and immunohistochemistry (IHC) of clinical specimens showed that increased GALNT2 expression levels were associated with an unfavorable prognosis and a higher tumor grade in human gliomas. Then, GALNT2 knockdown and overexpression were performed in glioma cell lines and verified by quantitative real-time PCR (qRT-PCR) and Western blotting. Functional assays demonstrated that GALNT2 was closely related to glioma cell proliferation, cycle transition, migration and invasion. Western blot analysis and lectin pull-down assays indicated that GALNT2 knockdown decreased the level of phosphorylated epidermal growth factor receptor (EGFR) and the expression of the Tn antigen on EGFR and affected the expression levels of p21, cyclin-dependent kinase 4 (CDK4), cyclinD1, matrix metalloproteinase 2 (MMP2) and matrix metalloproteinase 9 (MMP9) through the EGFR/PI3K/Akt/mTOR pathway. GALNT2 overexpression had the opposite effects. In vivo, the growth of orthotopic glioma xenografts in nude mice was distinctly inhibited by the expression of GALNT2 shRNA, and the tumors with GALNT2 shRNA exhibited less aggressiveness and reduced expression of Ki67 and MMP2. Overall, GALNT2 facilitates the malignant characteristics of glioma by influencing the O-glycosylation and phosphorylation of EGFR and the subsequent downstream PI3K/Akt/mTOR axis. Therefore, GALNT2 may serve as a novel biomarker and a potential target for future therapy of glioma.
Broadband transition from a high‐isolation transmission line to microstrip line
Authors: Guo Fangzhou , Xia Lei , Wu Qingzhi , Xu Ruimin 
Published: May 2019

A broadband transition from a novel high‐isolation quasi‐TEM transmission line (TL) to microstrip line is presented. The proposed design exploits a gradual transition to ensure electric field transformation and impedance matching between two types of TLs. The prototype is designed using back‐to‐back configuration and fabricated. The measurement reveals maximum insertion loss of 1.4 dB and return loss better than 15 dB from 0.5 to 20 GHz.
NCRC to improve linearity and sensitivity for RuO2 urea biosensor sensing measurement
Authors: Kuo Po‐Yu , Lian Ze‐Lin 
Published: May 2019

A novel noise‐cancelling readout circuit (NCRC) is proposed to improve the linearity and sensitivity of traditional voltage–time (V–T) measurement system for ruthenium dioxide (RuO2) urea biosensor. To reduce the non‐ideal effect related to traditional V–T measurement system that negatively threatened by the impact of power line noise, this NCRC adopts a new power line noise elimination scheme. Moreover, by employing the Twin‐T notch filter and the Sallen–Key low‐pass filter, the proposed NCRC can increase the linearity by 161% while retaining the sensitivity at an average level than V–T measurement system. A new NCRC for measuring the linearity and sensitivity of RuO2 urea biosensor is implemented by a real circuit board. The experimental results show that the proposed NCRC can achieve 0.956 linearity and 1.22 mV/(mg/dl) average sensitivity.
Vasculitis allergica – ein nicht-IgE-vermitteltes
Hypersensitivitätssyndrom
Authors: Lutze S. , Konschake W. , Ahmed M. , Arnold A. , Westphal T. , Riebe H. , Daeschlein G. , Jünger M. 
Published: May 2019

ZusammenfassungDie Diagnose „Vasculitis allergica“ suggeriert eine klassisch allergische
IgE-vermittelte Genese. Dies ist jedoch nicht der Fall, vielmehr handelt es sich
um einen hochkomplex ablaufenden Mechanismus, der häufig das eigentlich
auslösende Antigen vor der Detektion bewahrt.Die aktuelle Nomenklatur für dieses dermatologische Erkrankungsbild lautet kutane
IgM oder IgG Immunkomplex-Vaskulitis, es handelt sich um eine
leukozytoklastische Vaskulitis der postkapillären Venolen 3. Diese neue Einordnung legt die mit dem
ursprünglichen Namen einhergehende Assoziation mit einer typisch
IgE-vermittelten allergischen Erkrankung ab.Vaskulitiden werden immunologisch betrachtet den Immunkomplex-Erkrankungen, der
sogenannten Typ III Reaktion nach Coombs und Gell, zugeordnet 14, 15,
16. Sie werden als entsprechend dem
dahinter liegenden immunologischen Prozess als „non-IgE-mediated allergic
hypersensitivity Syndrom“ eingestuft 14,
15, 16. Viele Vaskulitiden machen sich klinisch zuerst an der Haut u. a.
durch akut auftretende, rasch progrediente Ulzerationen bemerkbar, häufig
assoziiert mit starker Schmerzhaftigkeit. Sie sind damit in der
Ursachenabklärung eines Ulcus cruris bedeutsam, rangieren hier aber unter den
seltenen Diagnosen.Der lange bestehende Begriff einer „leukozytoklastischen Vaskulitis“ für diese
Erkrankung steht entsprechend nicht länger für ein einzelnes Erkrankungsbild,
sondern vielmehr für ein histologisches Muster einer Gruppe von Vaskulitiden,
den sogenannten Immunkomplexvaskulitiden. 3
Hierbei handelt es sich von Gefäßkaliber überwiegend um „small vessel“
Vaskulitiden, diese können als „single organ vasculitis“ (SOV) mit alleiniger
Manifestation an der Haut oder auch als kutanes Teilsymptom einer anderen „multi
organ vasculitis“ (MOV) zum Beispiel im Rahmen eines systemischen Lupus
erythematodes auftreten 1. Die kutane IgM
oder IgG Immunkomplex-Vaskulitis zeigt den für Vaskulitiden klassisch plötzlich
auftretenden, rasch progredienten Verlauf und ist klinisch durch eine typische
Primäreffloreszenz, die palpable Purpura, mit hoher Inflammation
charakterisiert. 2 Im Therapiekonzept steht
an erster Stelle das auslösende Agens zu identifizieren und zu eliminieren 2, 42, 44. In der Regel zeigt dieser Typ von
Vaskulitis eine überwiegend residuenfreie Abheilung mit niedrigem Rezidivrisiko
unter der Voraussetzung, dass das auslösende Agens identifiziert und beseitigt
ist 2, 41,
42, 44.
Postoperative Nausea and Vomiting Following Craniotomy: Risk Factors and Complications in Context of Perioperative High-dose Dexamethasone Application
Authors: Burkhardt Till , Czorlich Patrick , Mende Klaus Christian , Treitz Annika , Kiefmann Rainer , Westphal Manfred , Schmidt Nils Ole 
Published: May 2019

Introduction Postoperative nausea and vomiting (PONV) is common in patients after craniotomy and may lead to severe postoperative complications. The aim of this study was to identify risk factors and postoperative complications associated with PONV in the context of perioperative high-dose dexamethasone administration.
Patients and Methods In this prospective single-center study, all patients planned for elective craniotomy for supra- and infratentorial lesions were eligible to be included. Any PONV in a 24-hour period after craniotomy was recorded and analyzed with regard to time to postoperative complications and the administration of perioperatively administered high-dose dexamethasone.
Results The overall PONV rate of 421 patients during a 9-month period was 18.1% (76 patients). Multivariate analysis revealed a significant association of PONV with female sex, infratentorial localization, age, and history of PONV. There was no association between PONV and postoperative complications such as intracranial hemorrhage, cerebrospinal fluid (CSF) leaks, or pneumonia. Perioperative administration of high-dose dexamethasone for prophylactic prevention of edema was the only significant risk factor for postoperative complications (odds ratio [OR]: 3.34; confidence interval [CI], 1.39–8.05; p < 0.01) with a highly significant association with the occurrence of CSF leaks (OR: 6.85; CI, 1.62–29.05; p < 0.01).
Conclusion The low PONV rate of 18.1% in this study may be the result of the frequent perioperative administration of high-dose dexamethasone for the prevention of edema. Our data indicate that perioperative high-dose dexamethasone is significantly associated with CSF leaks and can therefore not be recommended on a regular basis.
Significant Adhesion Reduction with 4DryField PH after Release of Adhesive Small Bowel Obstruction
Authors: Ahmad Mouhannad , Crescenti Fabio 
Published: May 2019

Background Peritoneal adhesions reoccur in up to 100% of cases, possibly causing complications like pain, secondary female infertility, and small bowel obstruction. The latter has a mortality rate of up to 15% during hospitalization. This study investigates if recurrence of peritoneal adhesions can be prevented by prophylactic use of the starch-based medical device 4DryField.
Methods The course of 40 patients with surgery for intestinal obstruction and, partially, second intervention was analyzed. In both operations, adhesion severity and extent were scored 0 (no adhesions) to III (massive/dense and vascular adhesions) and 0 (no adhesions) to III (extensive, covering more than approximately 25 × 25 cm), respectively. To prevent recurrence of adhesions all patients were treated with 4DryField gel (60 mL saline solution per 5 g powder), evenly distributed on the whole impaired intestine (including anastomoses) before abdominal closure. Follow-up was up to 1.5 years in a 3 to 6 months' interval.
Results Eight patients had relaparotomies on postoperative days 1 to 155. In the first operation, median adhesion severity score was III, median adhesion extent II. In redo-surgeries, significantly lower scores were detected (median adhesion severity: 0, p = 0.0003; median adhesion extent: 0, p = 0.0009). No adverse events related to the product were observed. One patient had later redo-surgery in another hospital due to recurrence of adhesions, one patient suffered from flatulence. All other patients were free of adhesion-related symptoms during follow-up.
Conclusion Based on the high severity of diseases and the significant reduction of adhesion severity and extent in redo-surgeries, 4DryField gel is a promising adjunct for adhesion prevention in bowel surgery. The favorable results should be confirmed in prospective randomized trials.
Direction of Flap Rotation in Propeller Flaps: Does It Really Matter?
Authors: Song Sinyoung , Jeong Hyung Hwa , Lee Yeonhun , Powers Hollie , Suh Young Chul , Christoffi Phaedon , Suh Hyunsuk Peter , Hong Joon Pio Jp 
Published: May 2019

Abstract
Background This article investigates the effect of 180° rotating propeller flaps and evaluates whether each flap has a “preferable” rotating direction.
Methods Part 1 evaluates the flap pedicle velocity and flow volume in neutral, 180°counterclockwise, and clockwise rotated position for 29 consecutive flaps. The data (velocity and volume) were divided into three groups: neutral, high value, and low value group then evaluated. Part 2 compares the outcome from the prospective study where a preferable rotation with high value was selected against 29 patients from 2012 to 2016 who had the same operation without selecting a preferable rotation direction.
Results In part 1, the three groups (neutral, high value, and low value groups) showed mean velocity of 28.06 ± 7.94, 31.92 ± 10.22, 24.41 ± 8.12 cm/s, respectively, and mean volume of 6.11 ± 4.95, 6.83 ± 6.69, 4.62 ± 3.55 mL/min, respectively. The mean velocity and volume of the perforator in the high value group were significantly higher than that in the low value group (p = 0.0001). In part 2, although no statistical significance in the outcome was observed, there were two cases of total, two cases of partial flap loss, and three cases of wound dehiscence in the patients where preferable rotations was not selected compared with only two wound dehiscence for flaps with preferable rotation.
Conclusion The velocity and flow of the flap are significantly different based on the rotation direction of the flap. Using the preferred rotation direction with statistically higher value of velocity and flow may increase the overall outcome of the propeller flap, especially where larger flaps are used.
Immediate Bilateral Breast Reconstruction Using Abdominally Based Flaps: An Analysis of the Nationwide Inpatient Sample Database
Authors: Holoyda Kathleen A. , Simpson Andrew M. , Ye Xiangyang , Agarwal Jayant P. , Kwok Alvin C. 
Published: May 2019

Abstract
Background Bilateral mastectomy rates are increasing in the United States. The abdomen is the most common harvest site for autologous reconstruction. Nationwide data were examined to determine differences in hospital charges, length of stay (LOS), and early postoperative complications following immediate bilateral pedicled transverse rectus abdominis myocutaneous (pTRAM), free TRAM (fTRAM), deep inferior epigastric perforator (DIEP), and superficial inferior epigastric artery (SIEA) perforator flaps and were compared with unilateral reconstruction.
Methods Patients who underwent immediate bilateral breast reconstruction using a single method of abdominally based reconstruction were identified using the 2009 to 2014 Nationwide Inpatient Sample Database. Outcomes included total hospital charges, LOS, and immediate postoperative complications.
Results We identified 13,348 cases of bilateral mastectomy with a single type of immediate bilateral autologous flap reconstruction. The majority were bilateral DIEP flaps. Mean total cost for bilateral pTRAM, fTRAM, DIEP, and SIEA flaps was US $21,886.80, US $28,839.40, US $30,051.30, and US $33,784.90, respectively (p < 0.0001). Mean LOS for bilateral pTRAM, fTRAM, DIEP, and SIEA was 4.3, 4.9, 4.5, and 5.4 days, respectively (p = 0.0002), and hematoma rates were 1.93, 2.61, 3.68, and 16.59%, respectively, (p = 0.0001), whereas return to the operating room for vascular anastomosis revision was 0, 1.63, 1.99, and 19.07%, respectively (p < 0.0001). Cost is less for unilateral pTRAM, fTRAM, and DIEP flaps (p < 0.0001). LOS is shorter for unilateral fTRAM versus bilateral (p < 0.0001). No differences were appreciated between unilateral and bilateral hematoma and reoperation rates for any reconstruction (p > 0.1).
Conclusion Immediate complication rates were higher in bilateral free flaps compared with bilateral pedicled flaps. pTRAM and fTRAM flap reconstructions are still performed frequently with acceptable immediate results without considering long-term morbidity, aesthetics, and abdominal muscle function. Bilateral SIEA free flaps were associated with significantly higher total cost, LOS, and complication rates compared with other groups. Complications were similar between unilateral and bilateral reconstruction procedures. While cost is significantly greater for bilateral procedures compared with unilateral pTRAM, fTRAM, and DIEP flaps, it is not doubled.
Supercharging Strategies for Prefabricated Flaps in a Rat Model
Authors: Xu Heng , Steinberger Zvi , Wo Yan , Li Ke , Kuo Chenghung , Tong Yun , Zhang Yixin 
Published: May 2019

Abstract
Background Limited survival area is an intractable problem in the clinical practice of prefabricated flaps. This study compared four strategies to find an effective method and to understand the potential mechanisms for supercharging.
Methods A prefabricated abdominal flap rodent model was prepared. Rats were randomly divided into five groups (n = 6/group). (A) Control group: prefabricated right side femoral vessels. Based on group A, various prefabricated vessels were added; (B) proximal venous supercharging group: right side superficial inferior epigastric vein (SIEV); (C) proximal arterial supercharging group: right side superficial inferior epigastric artery (SIEA); (D) distal venous supercharging group: left side SIEV; and (E) distal arterial supercharging group: left side SIEA. Macroscopic analysis, near-infrared fluorescence imaging, and microscopy were used to analyze the survival area, fluorescence area, and capillary density.
Results No significant differences in survival areas were found among supercharging groups (B–E), which were larger than in the control group. Near-infrared fluorescence imaging showed the areas of control and venous supercharging groups (A, B, and D) were smaller than in arterial groups (C and E). Capillary density areas in the right part of the flap in proximal supercharging groups (B and C) and left part of the flap in distal supercharging groups (D and E) were all greater than group A, with no significant differences among the other groups.
Conclusion Enhanced neovascularization is a useful supercharging strategy. Both arterial and venous vessel supercharging improved the survival area of prefabricated flaps.
Influence of capping ligands on the assembly of quantum dots and their properties
Authors: Al-Alwani Ammar J. , Shinkarenko O. A. , Chumakov A. S. , Pozharov M. V. , Begletsova N. N. , Kolesnikova Anna S. , Sevostyanova V. P. , Glukhovskoy E. G. 
Published: May 2019

In order to understand the effect of capping ligand on optical and electrical properties of semiconductor quantum dots (QDs), we have added liquid crystal (8CB) to the CdSe/CdS/ZnS QDs monolayer formed via the Langmuir Blodgett technique And studied emission spectra and conducting properties of resulting QDs. The assembly of QDs monolayer modified by liquid crystal (8CB) can be tuned by varying the temperature. The mechanism of the influence of capping ligands on the gap energy, dipole moment and charge distribution within (CdSe)13 cluster was studied via quantum chemical calculations, i.e. we have used density functional theory to systematically investigate the equilibrium configuration of QDs passivated by oleic acid and liquid crystal ligands. GRAPHICAL ABSTRACT
The structure solution of the F-type i-ZnMgHf from the X-ray diffraction
Authors: Buganski Ireneusz , Toyonaga Kotoba , Takakura Hiroyuki , Yamada Tsunetomo , de Boissieu Marc , Perez Olivier , Fertey Pierre , Wolny Janusz 
Published: May 2019

We report a successful growth of the ZnMgHf F-type icosahedral quasicrystal in the form of faceted single grains. By varying the heat treatment parameters we were able to obtain single crystals with a quality suitable for a single crystal X-ray diffraction which was conducted in a synchrotron facility. Ab initio structure solution by a charge flipping algorithm manifests the existence of two types of Bergman clusters. Clusters are differentiated by the preferential occupation of the high-symmetry positions by hafnium in a rhombic triacontahedron, being the outer shell of the atomic cluster. This paper is part of a Thematic Issue on The Crystallographic Aspects of Metallic Alloys.