bluuebunny/crossref_metadata_2025_split huggingface dataset:
The origins and non-canonical functions of macrophages in development and regeneration
Authors: Theret Marine , Mounier Remi , Rossi Fabio 
Published: May 2019

ABSTRACT
The discovery of new non-canonical (i.e. non-innate immune) functions of macrophages has been a recurring theme over the past 20 years. Indeed, it has emerged that macrophages can influence the development, homeostasis, maintenance and regeneration of many tissues and organs, including skeletal muscle, cardiac muscle, the brain and the liver, in part by acting directly on tissue-resident stem cells. In addition, macrophages play crucial roles in diseases such as obesity-associated diabetes or cancers. Increased knowledge of their regulatory roles within each tissue will therefore help us to better understand the full extent of their functions and could highlight new mechanisms modulating disease pathogenesis. In this Review, we discuss recent studies that have elucidated the developmental origins of various macrophage populations and summarize our knowledge of the non-canonical functions of macrophages in development, regeneration and tissue repair.
The Shh receptor Boc is important for myelin formation and repair
Authors: Zakaria Mary , Ferent Julien , Hristovska Ines , Laouarem Yousra , Zahaf Amina , Kassoussi Abdelmoumen , Mayeur Marie-Eve , Pascual Olivier , Charron Frederic , Traiffort Elisabeth 
Published: May 2019

ABSTRACT
Myelination leads to the formation of myelin sheaths surrounding neuronal axons and is crucial for function, plasticity and repair of the central nervous system (CNS). It relies on the interaction of the axons and the oligodendrocytes: the glial cells producing CNS myelin. Here, we have investigated the role of a crucial component of the Sonic hedgehog (Shh) signalling pathway, the co-receptor Boc, in developmental and repairing myelination. During development, Boc mutant mice display a transient decrease in oligodendroglial cell density together with delayed myelination. Despite recovery of oligodendroglial cells at later stages, adult mutants still exhibit a lower production of myelin basic protein correlated with a significant decrease in the calibre of callosal axons and a reduced amount of the neurofilament NF-M. During myelin repair, the altered OPC differentiation observed in the mutant is reminiscent of the phenotype observed after blockade of Shh signalling. In addition, Boc mutant microglia/macrophages unexpectedly exhibit the apparent inability to transition from a highly to a faintly ramified morphology in vivo. Altogether, these results identify Boc as an important component of myelin formation and repair.
Impact factors for safety, success, duration and radiation exposure in CT-guided interventions
Authors: Pradella Maurice , Trumm Christoph , Stieltjes Bram , Boll Daniel T , Zech Christoph J , Huegli Rolf W 
Published: May 2019

Objective: We aim to compare factors influencing safety, success rate and radiation dose of CT-guided biopsies and drainages in a non-teaching setting with experienced operators vs a teaching setting with residents. Methods: A total of 1021 cases were retrospectively analyzed regarding lesion size, distance from skin, procedure duration, radiation dose, complications and clinical success. Procedures were grouped into biopsies of lung, liver, (remaining) abdomen, musculoskeletal system (MSK) and drainages of any region. Procedures in non-teaching setting were performed by experienced operators (full time interventional radiology staff), teaching setting consisted of residents under supervision of interventional radiology staff. Results: Overall clinical success rate was 93.6 % [experienced (exp.) vs teaching setting: 93.5 and 93.6 %, p = 0.97]. Overall complication rate was 7.2% (5.7% minor, 1.6% major; exp. vs teaching: 8.0 and 6.5 %, p = 0.67]. Experienced operators performed chest and liver biopsies faster even though they were facing smaller lesions. Multiple regression analysis revealed that depth from skin significantly increased procedure duration by 36.8 s per cm (p < 0.001) and also radiation dose by 5.4 mGy per cm (p < 0.001) in all interventions. On average, teaching setting increased the duration of an intervention by 209.8 s and total radiation dose by 10.6 mGy (p < 0.001, p < 0.001 respectively). Conclusion: CT guided interventions can be performed safe und successful disregarding anatomical parameters or teaching setting. Depth from skin and teaching setting should be taken into account both from a clinical and a time-conscious point of view since they increase radiation dose and prolong operations. Advances in knowledge: This is the first study with >1000 interventions which shows and quantifies the impact of lesion depth and teaching setting in CT-guided interventions.
Quantitative analysis of Gd in the protein content of the brain following single injection of gadolinium-based contrast agents (GBCAs) by size exclusion chromatography
Authors: Kartamihardja Achmad Adhipatria Perayabangsa , Hanaoka Hirofumi , Andriana Putri , Kameo Satomi , Takahashi Ayako , Koyama Hiroshi , Tsushima Yoshito 
Published: May 2019

Objective:
To investigate the role of transporter proteins in gadolinium (Gd) distribution and retention in the brain after one high-dose injection of Gd-based contrast agent (GBCA).

Methods and materials:
30 ddY mice were randomly divided into three treatment groups to be intravenously injected with either Gadodiamide (linear GBCA), Gadobutrol (macrocyclic GBCA), or Gadoterate (macrocyclic GBCA) at a dose of 5 mmol/kg, while five mice in the control group received 250 µL saline. Five minutes (5 min) and ten days (10d) post-injection, the cerebrospinal fluid (CSF), choroid plexus (CP), and meninges and associated vasculature (MAV) were collected. The brain was then dissected to obtain the olfactory bulb, cerebral cortex, hippocampus, cerebellum, and brainstem. Proteins were extracted and separated by a size-exclusion high-performance liquid chromatography (SEC) system, and Gd concentrations were quantified by inductively coupled plasma mass spectrometry (ICP-MS).

Results:
5 m post-injection, the Gadodiamide group had the highest Gd concentration, while Gadoterate had the lowest Gd concentration in all parts of the brain (p &lt; .05). Gd concentration was highest in the cerebrospinal fluid (CSF) of the Gadodiamide group (578.4 ± 135.3 nmol), while Gd concentration was highest in MAV in the Gadobutrol group (379.7 ± 75.4 nmol) at 5 min post-injection. At 10d, in spite of the significant decrease of Gd from all GBCAs ( p &lt; 0.01), retained Gd from Gadodiamide was detected all over the brain in several molecules that varied in size. Gd from Gadobutrol detected in the olfactory bulb (8.7 ± 4.5 nmol) was significantly higher than in other parts of the brain. Although most Gd from Gadobutrol was found in molecules similar in size to Gadobutrol, it was also found in several protein molecules of molecular size larger than the contrast agents. Only a small amount of Gd from Gadoterate was found in the brain.

Conclusion:
GBCAs may be able to pass through intact brain barriers, and the chemical structures of GBCAs may affect the penetration capability of Gd into the brain. Retained Gd in the brain tissue from Gadodiamide and Gadobutrol may be bound to some organic molecules, including proteins.

Advances in knowledge:
Intact GBCA are able to penetrate a series of brain barrier immediately after administration regardless the type of the chelate. Gd may be bound with macromolecules that may cause Gd retention in the brain.
Editorial
Authors: Weersma Laodicéia Amorim , Coelho Arnaldo Fernandes Matos 
Published: May 2019

O cenário em direção ao que se denomina Internet of Things (IoT) tem impactado diretamente no contexto econômico-financeiro e tende a trazer à tona, segundo Weersma, Coelho e Shintaku (2019), uma sociedade contemporânea sedimentada em processos complexos e dinâmicos, formada como uma teia por atores que buscam o alcance de objetivos nos mais diversos contextos e perspectivas. A partir dessa percepção, entendemos que as sociedades parecem ficar mais fluídas, o que vem ao encontro com as afirmações de Bauman (2001) de que estamos vivendo em tempos líquidos. [...].
Recalibrating the ‘world map’ of palliative care development
Authors: Baur Nicole , Centeno Carlos , Garralda Eduardo , Connor Stephen , Clark David 
Published: May 2019

Background: Despite growing interest from policy makers, researchers and activists in the global development of palliative care, there is still little science to underpin it. This study presents the methods deployed in the creation of a ‘world map’ of palliative care development. Building on two previous iterations, with improved rigour and taking into account reviewers’ feedback, the aim of this recalibrated version of the study is to determine the level of palliative care development in 198 United Nations recognised countries in 2017, whilst ensuring comparability with previous versions. We present methods of data collection and analysis. Methods and analysis: Primary data on the level of palliative care development in 2017 was collected from in-country experts through an online questionnaire and, where required, supplemented by published documentary sources and grey literature. Data relating to the total population of each country as well as per capita opioid consumption were derived from independent sources. Data analysis was conducted according to a new scoring system and algorithm developed by the research team. Ethics and dissemination: The study was approved by the University of Glasgow College of Social Sciences Research Ethics Committee. Findings of the study will be disseminated in peer-reviewed journals, as a contribution to the second edition of the Global Atlas of Palliative Care at the End-of-Life, and via social media, including the Glasgow End of Life Studies Group blog and the project website. Limitations of the study: There are potential biases associated with self-reporting by key in-country experts. In some countries, the identified key expert failed to complete the questionnaire in whole or part and data limitations were potentially compounded by language restrictions, as questionnaires were available only in three European languages. The study relied in part on data from independent sources, the accuracy of these data could not be verified.
“Dice”-sion–Making Under Uncertainty: When Can a Random Decision Reduce Risk?
Authors: Delage Erick , Kuhn Daniel , Wiesemann Wolfram 
Published: May 2019

Stochastic programming and distributionally robust optimization seek deterministic decisions that optimize a risk measure, possibly in view of the most adverse distribution in an ambiguity set. We investigate under which circumstances such deterministic decisions are strictly outperformed by random decisions, which depend on a randomization device producing uniformly distributed samples that are independent of all uncertain factors affecting the decision problem. We find that, in the absence of distributional ambiguity, deterministic decisions are optimal if both the risk measure and the feasible region are convex or alternatively, if the risk measure is mixture quasiconcave. We show that some risk measures, such as mean (semi-)deviation and mean (semi-)moment measures, fail to be mixture quasiconcave and can, therefore, give rise to problems in which the decision maker benefits from randomization. Under distributional ambiguity, however, we show that, for any ambiguity-averse risk measure satisfying a mild continuity property, we can construct a decision problem in which a randomized decision strictly outperforms all deterministic decisions. This paper was accepted by Teck Ho, optimization.
Sharing the Revenues from Broadcasting Sport Events
Authors: Bergantiños Gustavo , Moreno-Ternero Juan D. 
Published: May 2019

We study the problem of sharing the revenues from broadcasting sport league events among participating teams. We provide direct, axiomatic, and game-theoretical foundations for two focal rules: the equal-split rule and concede-and-divide. The former allocates the revenues generated from broadcasting each game equally among the participating teams in the game. The latter concedes each team the revenues from its fan base and divides equally the residual. We also provide an application studying the case of sharing the revenue from broadcasting games in La Liga, the Spanish Football League. We show that hybrid schemes, combining our rules with lower bounds and performance measures, yield close outcomes to the current allocation being implemented by the Spanish National Professional Football League Association. This paper was accepted by Manel Baucells, decision analysis.
Should midwives learn to scan for presentation? Findings from a large survey of midwives in the UK
Authors: Barnfield Lauren , Bamfo Jacqueline , Norman Lynne 
Published: May 2019

Background Undiagnosed breech presentation in labour is associated with fetal morbidity and mortality, and may cause significant maternal anxiety. With increasing availability of scan machines, ultrasound is now widely used in UK maternity settings. Bedside presentation scans are usually undertaken by junior doctors, often leading to delays and frustration among staff and patients. Aims To assess local practices and attitudes towards midwives scanning for presentation. Methods A nine-question anonymous online survey was first disseminated by email locally, and then via social media. It was open to all UK non-sonographer midwives and midwifery students. A total of 870 responses were received between January and April 2018. Findings The survey highlighted significant variation in practice across the UK. Of those who did not scan for presentation, 85.2% felt that being able to do so would improve their practice, with the majority of respondents highlighting improvements in patient safety and satisfaction as well as workflow. Conclusions This demonstrates that demand exists for a postgraduate or accredited short course to teach midwives how to safely and accurately scan to assess fetal presentation.
Collaborative coaching and learning in midwifery clinical placements
Authors: Tweedie Kirsty , Yerrell Jodie , Crozier Kenda 
Published: May 2019

The model of coaching and collaborative learning is based on the nursing model of collaborative learning in practice developed at University of East Anglia and supported by Health Education East of England. The model was adapted to fit the midwifery antenatal and postnatal ward, where it was trialled between September 2016 and August 2017. During the trial, students, coaches, mentors and other staff on the ward were supported by the clinical education midwife. Evaluation data were collected in the normal module evaluations and showed overall satisfaction with the model and the opportunities for sharing learning. The model is now being rolled out to other placement areas. Keys to success included good preparation of the clinical placement areas and supported from a practice educator.
Applying AHP in Conflict Resolution
Authors: Vargas Luis G , Zoffer H. J. 
Published: May 2019

The current failure to resolve conflicts worldwide highlights the need for a different approach to conflict resolution. A new International Center for Conflict Resolution (IC4CR), to be housed in the Joseph M. Katz Graduate School of Business, was funded by the University of Pittsburgh Chancellor Patrick Gallagher in response to a proposal by professors Luis Vargas and Jerry Zoffer.
The mission of IC4CR is to provide decision makers with an in-depth understanding of the negotiating positions of all parties and recommend implementation guidelines, based on preferences and priorities, to facilitate resolution of otherwise intractable conflicts.
We propose to implement this mission by conducting studies of diplomatic and corporate conflicts using the Analytic Hierarchy Process (AHP).
Book Reviews
Authors: Melkumova-Reynolds Jana , Velody Rachel , Tsui Christine , Reinach Simona Segre 
Published: May 2019

Experimental Fashion: Performance Art, Carnival and the Grotesque Body, Francesca Granata (2017, first edition) London and New York: I.B. Tauris, 217 pp., ISBN 978-1-78453-379-3, p/bk, £14.99; ISBN 978-1-78453-378-6, h/bk, £63
Faith and Fashion in Turkey: Consumption, Politics and I slamic Identities, Nazlı Alimen (2018, first edition) London: I.B. Tauris, 305 pp., ISBN 978-1-78831-166-3, h/bk, £72.00
Fashion in Multiple Chinas: Chinese Styles in the Transglobal Landscape, Wessie Ling and Simona Segre Reinach (eds) (2018, first edition) London and New York: I.B. Tauris, 272 pp., ISBN 978-1-78453-864-4, h/bk, £64.00, US $94.00
Dizionario della moda: Inglese/Italiano, Italiano/Inglese, Mariella Lorusso (2017, first edition) Bologna: Zanichelli, 640 pp., ISBN 978-8-80816-489-6, p/bk 24.50
HIRSCHSPRUNG’S DISEASE: A LITERATURE REVIEW
Authors: Budib Camyla Lemos , Fontana Jean Carlos , Gomes Hígor Guimarães , Zeron Rubens Moura Campos , Albuquerque Victor Campos de , Nogueira Paulo Luiz Batista 
Published: May 2019

Abstract: The Hirschsprung's disease (HSCR) is a congenital malformation, which creates a defect in the ganglion cells migration to the distal intestine. This situation will cause a problem in the motor coordination generating a functional obstruction and retention of fecal content. The diagnosis of this disease is histological, and the treatment is the surgery. Keywords: Hirschsprung's disease, congenital, obstruction.
Habit and hedonic motivation are the strongest influences in mobile learning behaviours among higher education students in Malaysia
Authors: Moorthy Krishna , Tzu Yee Tsen , Chun T'ing Loh , Vija Kumaran Vikniswari 
Published: May 2019

Mobile learning has become a common experience in higher education and in the professional workforce. However, the readiness of accounting students to engage in such learning appears to be weaker than in other disciplines. Therefore, this study set out to identify the factors affecting accounting students’ behavioural intention (BI) to accept mobile learning. The participants of this study were 358 accounting students of public universities in Malaysia. The study was anchored in the unified theory of acceptance and use of technology 2 (UTAUT2) (Venkatesh, Thong & Xu, 2012), which has been employed by researchers in various research areas such as mobile payments, e-learning, mobile banking, and online shopping. The study revealed that habits have the most influence on accounting students’ intention to adopt mobile learning through an investigation of technology acceptance in the domain of mobile learning. From the perspective of universities, the study posits that consistent usage of mobile learning could be encouraged through processes to nurture students’ habits when using mobile learning system as a tool to complete tasks. Findings provide a reference for the future UTAUT2 and mobile learning related studies.
Principled Utility Discounting Under Risk
Authors: Mintz-Woo Kian 
Published: May 2019

AbstractUtility discounting in intertemporal economic modelling has been viewed as problematic, both for descriptive and normative reasons. However, positive utility discount rates can be defended normatively; in particular, it is rational for future utility to be discounted to take into account model-independent outcomes when decision-making under risk. The resultant values will tend to be smaller than descriptive rates under most probability assignments. This also allows us to address some objections that intertemporal considerations will be overdemanding. A principle for utility discount rates is suggested which is rooted in probability discounting. Utility discounting is defended against objections from Parfit (1984) and Broome (2005); Broome (2012). A sample utility discount rate is estimated.
Cabergoline in severe ectopic or occult Cushing’s syndrome
Authors: Ilie Mirela Diana , Raverot Véronique , Tronc François , Vasiljevic Alexandre , Borson-Chazot Françoise , Raverot Gérald 
Published: May 2019

Context
Cabergoline has been shown to have some effect in the treatment of moderate Cushing’s disease, but its effectiveness in Cushing’s syndrome of ectopic or occult origin remains to be investigated.

Case series
In this case series, cabergoline was used in combination with steroidogenesis inhibitors in nine patients with severe Cushing’s syndrome of ectopic or occult origin. Cabergoline’s effectiveness enabled rapid withdrawal of the steroidogenesis inhibitors and long-term control of the hypercortisolism in three of the cases.

Review of the literature
In the literature, we found only 11 cases of ectopic or occult Cushing’s syndrome treated with dopamine receptor agonists, alone or in combination. Yet of these 11 cases, 10 responded.

Conclusions
Although limited, the existing experience highlights the potential value of cabergoline in the treatment of ectopic or occult Cushing’s syndrome.
Contaminación en el Lago de Tota, Colombia: toxicidad aguda en Daphnia magna (Cladocera: Daphniidae) e Hydra attenuata (Hydroida: Hydridae)
Authors: Barrera Herrera July Andrea , Espinosa Adriana Janneth , Álvarez Juan Pablo 
Published: May 2019

La cuenca del Lago de Tota ha sido modificada por diversas actividades humanas, como deforestación, piscicultura y el monocultivo de cebolla larga (Allium fistulosum) con un elevado uso de agroquímicos y gallinaza cruda, causando deterioro de las características ecológicas del sistema léntico de alta montaña más grande de Colombia. En este trabajo se implementaron pruebas de toxicidad para determinar posibles efectos deletéreos sobre H. attenuata y D. magna. Se aclimataron los organismos y validaron los ensayos de toxicidad en condiciones de laboratorio, posteriormente se realizó la evaluación de agua y sedimentos (elutriados) provenientes de afluentes de la cuenca del lago: Hato Laguna, El Tobal, Los Pozos y Agua Blanca, durante dos periodos hidroclimáticos contrastantes. Se evidenció una mayor sensibilidad con los ensayos en H. attenuata, ya que señalan que aguas y elutriados de Hato Laguna, El Tobal y Los Pozos generaron respuestas de subletalidad (Kruskal-Wallis; P < 0.05) y letalidad. Se registra presencia positiva de al menos cinco plaguicidas no cuantificados antes en la cuenca (clorotalonilo, aldrin, dieldrin, DDT y congéneres). Estos resultados indicarían una potencial influencia negativa de las actividades antropogénicas sobre organismos acuáticos nativos, con posibles consecuencias sobre la composición, estructura y función de las comunidades hidrobiológicas.
Solid solution Ca<sub>12</sub>Al<sub>14</sub>O<sub>33±δ</sub>: V<sup>5+</sup>, Mo<sup>5+</sup>
Authors: Tolkacheva A. S. , Shkerin S.  N. , Plaksin S. V. , Pankratov A. A. , Moskalenko N. I. 
Published: May 2019

A solid solution of the composition Ca12–x(Al14Vx)O33+δ(0 ≤ х ≤ 0,07) was synthesized. A combination of methods established the charge state of vanadium in a solid solution. The principle of filling with a dopant crystallographic positions in the structure of mayenite is proposed: vanadium cations replace a small number of aluminum positions, presumably in octahedral coordination. The temperature dependence of the electrical conductivity of Ca11,93(Al14V0,07)O33+δ was studied by the impedance spectroscopy. It is shown that doping of mayenite with vanadium increases the value of electrical conductivity by an order of magnitude.