bluuebunny/crossref_metadata_2025_split huggingface dataset:
Children’s description of pain through drawings and dialogs: A concept analysis
Authors: Ebrahimpour Fatemeh , Pashaeypoor Shahzad , Salisu Waliu Jawula , Cheraghi Mohammad Ali , Sadat Hosseini Akram Sadat 
Published: October 2018

AbstractAimTo present a concept analysis of pain in children's drawings and dialogs.IntroductionThe complexity and subjectivity of the concept of pain in children remain ambiguous. As a result, children are exposed to inappropriate diagnosis and inadequate treatment. Children can describe or draw their painful experiences. Analysing the concept of pain based on children's experiences can help identify, assess and properly manage and treat pain in children.DesignConcept analysis.MethodsWalker and Avant's framework for concept analysis was used in this current study.ResultsMajor aspects of pain revealed in this concept analysis are affected by children's different concerns about pain. The description of pain in children with chronic diseases or chronic pain is completely different from that in healthy children. Children perceive pain to be internal, external and emotional. Pain in children is associated with poor psychological and emotional conditions, which add new features and aspects to the concept of pain. Children's descriptions and drawings of pain indicate different concepts of pain in their minds. From the perspective of children, pain has an identity that is formed based on reality.ConclusionWhen developing pain evaluation tools, it is necessary to address the characteristics of pain. In the case of chronic pain, emotional effects of pain on children's psyche need extra attention. Child‐based pain management guidelines can then be formulated with the results of relevant concept analyses. Pain assessment is a major part of pain management in children. By considering the characteristics of the concept of pain, the efficiency and usefulness of developed tools can be enhanced to create advancement in paediatric pain management.
How I approach expressing condolences and longitudinal remembering to a family after the death of a child
Authors: Weaver Meaghann S. , Lichtenthal Wendy G. , Larson Kara , Wiener Lori 
Published: October 2018

AbstractBereaved families fear their child being forgotten by those who knew their loved child, including their child's oncology team. Thoughtfully timed, family‐centric condolences shared by pediatric oncology team members have the potential to extend our compassion and kindness toward a family during the darkness of grief. Well‐intended medical teams sometimes feel “at a loss” in terms of what to say to a grieving family and how or when to say it. This paper provides a tangible overview of written or verbal condolence communication in a format that can be personalized to the provider and the patient's family.
Psychosocial well‐being of long‐term survivors of pediatric head–neck rhabdomyosarcoma
Authors: Vaarwerk Bas , Schoot Reineke A. , Maurice‐Stam Heleen , Slater Olga , Hartley Benjamin , Saeed Peerooz , Gajdosova Eva , van den Brekel Michiel W. , Balm Alfons J.M. , Hol Marinka L.F. , van Jaarsveld Stefanie , Kremer Leontien C.M. , Ronckers Cecile M. , Mandeville Henry C. , Pieters Bradley R. , Gaze Mark N. , Davila Fajardo Raquel , Strackee Simon D. , Dunaway David , Smeele Ludi E. , Chisholm Julia C. , Caron Huib N. , Grootenhuis Martha A. , Merks Johannes H. M. 
Published: October 2018

AbstractBackgroundHead and neck rhabdomyosarcoma (HNRMS) survivors are at risk to develop adverse events (AEs). The impact of these AEs on psychosocial well‐being is unclear. We aimed to assess psychosocial well‐being of HNRMS survivors and examine whether psychosocial outcomes were associated with burden of therapy.ProcedureSixty‐five HNRMS survivors (median follow‐up: 11.5 years), treated in the Netherlands and the United Kingdom between 1990 and 2010 and alive ≥2 years after treatment visited the outpatient multidisciplinary follow‐up clinic once, in which AEs were scored based on a predefined list according to the Common Terminology Criteria for Adverse Events. Survivors were asked to complete questionnaires on health‐related quality of life (HRQoL; PedsQL and YQOL‐FD), self‐perception (KIDSCREEN), and satisfaction with appearances (SWA). HRQoL and self‐perception scores were compared with reference values, and the correlation between physician‐assessed AEs and psychosocial well‐being was assessed.ResultsHNRMS survivors showed significantly lower scores on PedsQL school/work domain (P ≤ 0.01, P = 0.02, respectively), YQOL‐FD domains negative self‐image and positive consequences (P ≤ 0.01, P = 0.04, respectively) compared with norm data; scores on negative consequences domain were significantly higher (P = 0.03). Over 50% of survivors negatively rated their appearances on three or more items. Burden of AEs was not associated with generic HRQoL and self‐perception scores, but was associated with disease‐specific QoL (YQOL‐FD).ConclusionIn general, HRQoL in HNRMS survivors was comparable to reference groups; however, survivors did report disease‐specific consequences. We therefore recommend including specific questionnaires related to difficulties with facial appearance in a systematic monitoring program to determine the necessity for tailored care.
Chemical stiffening of constructs between polymeric microparticles based on a hyaluronic acid derivative and mesenchymal stem cells: rheological and in vitro viability studies
Authors: Palumbo Fabio S , Agnello Stefano , Fiorica Calogero , Pitarresi Giovanna , Giammona Gaetano 
Published: October 2018

AbstractOur research group has recently developed microparticles of a hyaluronic acid derivative used for bottom‐up growth of microparticles/human mesenchymal stem cells (hMSCs). In this work, we investigated a strategy to increase the stiffening of aggregated constructs between microparticles and hMSCs. In particular, we applied a Michael‐type crosslinking procedure between microparticles to allow a chemically driven and cell‐compatible stiffening of constructs. Two batches of microparticles were functionalized with thiol and maleimide groups, respectively, and were then mixed to allow chemical crosslinking. The adhesion of hMSCs was controlled through addition of the adhesive peptide cyclo(‐Arg‐Gly‐Asp‐D‐Phe‐Cys) (cyRGDC). Rheological measurements performed in this study showed that the chemical stiffening strategy allows the G′ modulus of bottom‐up growing constructs to be increased, while viability tests suggest that the chemical procedure did not negatively affect cell viability compared with constructs obtained without chemical crosslinking. © 2018 Society of Chemical Industry
Design, Synthesis and 3D‐QSAR of New Quinazolin‐4(3H)‐one Derivatives Containing a Hydrazide Moiety as Potential Fungicides
Authors: Wang Xiaobin , Wang Mengqi , Yan Jinghua , Chen Min , Wang An , Mei Yudong , Si Weijie , Yang Chunlong 
Published: October 2018

AbstractA series of quinazolin‐4(3H)‐one derivatives containing a hydrazide moiety were designed, synthesized and characterized in detail via FT‐IR, 1H NMR, 13C NMR and HRMS spectra. The antifungal activities against Rhizoctonia solani (Rs) and Fusarium graminearum (Fg) were evaluated in vitro. The bioassay results indicated that most of the title compounds exhibited significant antifungal activities against Rs and Fg. Strikingly, the EC50 values of some title compounds against Rs are obviously superior to that of the positive control carbendazim. Based on the antifungal bioassay results against Rs, the comparative molecular filed analysis (CoMFA) and comparative molecular similarity index analysis (CoMSIA) models were generated to investigate the structure‐activity relationship of title compounds against Rs. The analytical results indicated that these two models exhibited good predictive accuracies and could provide significant structural insights for the design of bioactive quinazolin‐4(3H)‐one derivatives containing a hydrazide moiety.
Glycination: A Simple Strategy to Enhance the Cycling Performance of Perylene Dianhydride for Secondary Li–Ion Battery Applications
Authors: Medabalmi Veerababu , Ramanujam Kothandaraman 
Published: October 2018

AbstractPerylene‐based organic frameworks have received much attention in organic Li‐ion batteries (OLIBs) regime by virtue of their extended conjugation, flexibility and structural robustness. However, attaining stable cyclability is a major challenge due to their solubility issues and gradual decomposition. Herein, we report a simple strategy for realizing long‐term cyclability by the introduction of glycine group into perylene tetracarboxylic dianhydride (PTCDA). The resultant compound N,N′‐bis(glycinyl)perylene diimide (H2PDI) exhibited outstanding cyclability and retained 64% of theoretical capacity even after 2000 cycles with almost 100% coulombic efficiency. To the best of our knowledge, this is the best cycling performance of perylene based materials reported for OLIBs till date.
Controllable in‐situ Synthesis of Cu–Cu2O Heterostructures with Enhanced Visible‐light Photocatalytic Activity
Authors: Ma Bo , Kong Chuncai , Lv Jian , Zhang Weixin , Guo Jian , Zhang Xiaojing , Yang Zhimao , Yang Sen 
Published: October 2018

AbstractThe activity of heterogeneous catalysis depends on charge transfer from catalyst surface to adsorbed molecules. Thus the influence of nanoparticle‐loaded heterostructures and core‐shell heterostructures on photocatalytic performance is significant to be demonstrated. In this work, Cu–Cu2O heterostructures were controllably synthesized by in‐situ reduction of Cu nanoparticles from octahedral Cu2O crystals and forming nanoparticle‐loaded heterostructures (partial coverage I and partial coverage II) and the core‐shell heterostructure (full coverage) by controlling the reaction time. The results indicate that optimal size and quantity of the loaded nanoparticles are required to attain the desirable performance by effectively separating and transferring photo‐excited carriers.
Directing Block Copolymer Self‐Assembly on Patterned Substrates
Authors: Gunkel Ilja 
Published: October 2018

AbstractSelf‐assembling block copolymer films provide access to a variety of different nanostructured patterns in one, two, and three dimensions. However, in the absence of any templating, these nanostructures suffer from defects, often limiting utility. Directed block copolymer self‐assembly uses patterned substrates that effectively suppress defect formation and allow the creation of desired patterns. The two main directed self‐assembly techniques, chemoepitaxy and graphoepitaxy, employ chemically and topographically patterned substrates, respectively, to direct the block copolymer assembly in thin films. Their successful application in generating defect‐free patterns in films of block copolymers exhibiting particular morphologies is summarized in this concept article. The possible role of directed self‐assembly in extending nanostructured patterning from two to three dimensions is also discussed.
Trustworthiness requirement‐oriented software process modeling
Authors: Zhang Xuan , Wang Xu , Kang YanNi 
Published: October 2018

AbstractTrustworthy software is delivered by enacting trustworthy software processes. The purpose of this paper is to propose an approach to modeling trustworthiness requirement‐oriented software processes. First, based on the aspect‐oriented modeling techniques, separation of concerns is used to separate the crosscutting activities and the core activities according to the different trustworthiness requirements and functional requirements. A goal‐oriented modeling and reasoning method for trustworthiness requirements to find the crosscutting activities that satisfy multiple trustworthiness requirements is presented. Then, base processes are modeled for functional requirements. The crosscutting activities for trustworthiness requirements are decomposed into processes or tasks and encapsulated in aspects that are woven into the base processes. In the weaving procedure, correct weaving methods between multiple aspects and between aspects and base processes are designed. Errors or mistakes of aspect‐oriented process modeling are prevented. Finally, trustworthy third‐party certification authority software is studied systematically in a case study, and performance evaluations are conducted to show the cost and effect of the approach.
Personalized Anchor Charts: Bridging Small‐Group Work to Independence
Authors: Bacchioni Shelby , Kurstedt Rosanne L. 
Published: October 2018

AbstractIf you were to walk into this second‐grade classroom during reading workshop, you would notice students reading books specific to their reading level and interest. You would also notice students using different tools to support their reading development. One of the teacher's goals is to help students become independent readers who are able to sustain their reading with fewer and fewer supports. With the assistance of a university‐based literacy coach, the teacher used personalized anchor charts to enhance student engagement and ownership during independent reading. In this article, the authors discuss the teacher's process to bridge students’ independence, from small‐group guided practice to independent reading, with personalized anchor charts. The authors also provide readers with insights into how to implement such work in their own classrooms.
Six Tips for Using Culturally Relevant Texts in Diverse Classrooms
Authors: Kibler Kristin , Chapman Lindsey A. 
Published: October 2018

AbstractThe use of culturally relevant texts can support students’ reading development, foster a love of reading, help students form positive identities, and broaden their social consciousness. Well‐matched culturally relevant texts have particular promise in increasingly diverse classrooms. Drawing on the academic literature and their experience as teachers and literacy coaches, the authors present six tips for the effective use of culturally relevant texts. Tips and suggestions for practice focus on teachers examining their positionality, creating a safe learning environment, learning about their students’ backgrounds, selecting texts that are culturally relevant, creating transformative reading experiences, and extending beyond the text.
Impact of ethnicity on adverse perinatal outcome in women with chronic hypertension: a cohort study
Authors: Webster L. M. , Bramham K. , Seed P. T. , Homsy M. , Widdows K. , Webb A. J. , Nelson‐Piercy C. , Magee L. , Thilaganathan B. , Myers J. E. , Chappell L. C. 
Published: October 2018

ABSTRACTObjectiveTo assess the impact of maternal ethnicity on the risk of adverse perinatal outcome in pregnant women with chronic hypertension.MethodsDemographic and delivery data were collated of women with chronic hypertension and singleton pregnancy who delivered at one of three UK obstetric units between 2000 and 2014. Multivariable logistic regression models were used to calculate risk ratios (RR), according to ethnic group, for adverse perinatal outcome, adjusted for other maternal characteristics including age, parity, body mass index, smoking status, deprivation index and year of delivery. The impact of maternal ethnicity on birth‐weight centile calculation was investigated by comparing the birth‐weight centile chart customized for ethnicity (Gestation Related Optimal Weight; GROW) with a birth‐weight centile calculator that does not adjust for that factor (INTERGROWTH‐21st).ResultsThe study cohort included 4481 pregnancies (4045 women) with chronic hypertension. Women of white ethnicity accounted for 47% (n = 2122) of the cohort and 36% (n = 1601) were of black, 8.5% (n = 379) of Asian and 8.5% (n = 379) of other ethnicity. The overall incidence of stillbirth was 1.6%, that of preterm birth < 37 weeks was 16% and that of fetal growth restriction (birth weight < 3rd centile) was 11%. Black women, compared with white women, had the highest risk for all adverse perinatal outcomes, with stillbirth occurring in 3.1% vs 0.6% of pregnancies (adjusted RR (aRR), 5.56 (95% CI, 2.79–11.09)), preterm birth < 37 weeks in 21% vs 11% (aRR, 1.70 (95% CI, 1.43–2.01)) and birth weight < 3rd centile in 15% vs 7.4% (aRR, 2.07 (95% CI, 1.71–2.51)). Asian women, compared with white women, were also at increased risk of adverse perinatal outcome, with stillbirth occurring in 1.6% vs 0.6% (aRR, 3.03 (95% CI, 1.11–8.28)), preterm birth < 37 weeks in 20% vs 11% (aRR, 1.82 (95% CI, 1.41–2.35)) and birth weight < 3rd centile in 12% vs 7.4% (aRR, 1.69 (95% CI, 1.24–2.30)). The sensitivity and specificity for prediction of infants requiring neonatal unit admission were 40% and 93%, respectively, for those with birth weight < 3rd centile according to GROW charts, compared with 16% and 96%, respectively, for those with birth weight < 3rd centile according to INTERGROWTH‐21st charts.ConclusionsBlack ethnicity, compared with white, is associated with the greatest risk of adverse perinatal outcome in women with chronic hypertension, even after adjusting for other maternal characteristics. Women of Asian ethnicity are also at increased risk, but to a lesser extent. Copyright © 2018 ISUOG. Published by John Wiley & Sons Ltd.
Choanal atresia and stenosis: Development and diseases of the nasal cavity
Authors: Kurosaka Hiroshi 
Published: October 2018

Proper craniofacial development in vertebrates depends on growth and fusion of the facial processes during embryogenesis. Failure of any step in this process could lead to craniofacial anomalies such as facial clefting, which has been well studied with regard to its molecular etiology and cellular pathogenesis. Nasal cavity invagination is also a critical event in proper craniofacial development, and is required for the formation of a functional nasal cavity and airway. The nasal cavity must connect the nasopharynx with the primitive choanae to complete an airway from the nostril to the nasopharynx. In contrast to orofacial clefts, defects in nasal cavity and airway formation, such as choanal atresia (CA), in which the connection between the nasal airway and nasopharynx is physically blocked, have largely been understudied. This is also true for a narrowed connection between the nasal cavity and the nasopharynx, which is known as choanal stenosis (CS). CA occurs in approximately 1 in 5,000 live births, and can present in isolation but typically arises as part of a syndrome. Despite the fact that CA and CS usually require immediate intervention, and substantially affect the quality of life of affected individuals, the etiology and pathogenesis of CA and CS have remained elusive. In this review I focus on the process of nasal cavity development with respect to forming a functional airway and discuss the cellular behavior and molecular networks governing this process. Additionally, the etiology of human CA is discussed using examples of disorders which involve CA or CS.This article is categorized under:
Signaling Pathways > Cell Fate Signaling
Comparative Development and Evolution > Model Systems
Birth Defects > Craniofacial and Nervous System Anomalies
Stereotactic Ablative Radiotherapy (SABR/SBRT) for Hepatocellular Carcinoma
Authors: Rhieu Byung-Han , Narang Amol K. , Meyer Jeffrey 
Published: October 2018

Abstract
Purpose of Review
Liver-directed SABR (stereotactic ablative body radiotherapy) is emerging as an effective local therapy option for HCC (hepatocellular carcinoma). This review summarizes recent clinical progresses and proposes future directions.

Recent Findings
SABR is an effective and safe, non-invasive local therapy option for HCC in the primary and salvage treatment settings, as well as a bridge to liver transplantation in selected patients. Randomized trials comparing SABR with other locoregional modalities are currently ongoing.

Summary
Research efforts are being made toward better predicting normal tissue toxicity and tumor radiosensitivity for a tailored maximal safe treatment in HCC SABR. More recently, potential synergy with immunotherapies is of increasing interest in HCC.
Longevity and Lifespan Variation by Educational Attainment in Spain: 1960–2015
Authors: Permanyer Iñaki , Spijker Jeroen , Blanes Amand , Renteria Elisenda 
Published: October 2018

AbstractFor a long time, studies of socioeconomic gradients in health have limited their attention to between-group comparisons. Yet, ignoring the differences that might exist within groups and focusing on group-specific life expectancy levels and trends alone, one might arrive at overly simplistic conclusions. Using data from the Spanish Encuesta Sociodemográfica and recently released mortality files by the Spanish Statistical Office (INE), this is the first study to simultaneously document (1) the gradient in life expectancy by educational attainment groups, and (2) the inequality in age-at-death distributions within and across those groups for the period between 1960 and 2015 in Spain. Our findings suggest that life expectancy has been increasing for all education groups but particularly among the highly educated. We observe diverging trends in life expectancy, with the differences between the low- and highly educated becoming increasingly large, particularly among men. Concomitantly with increasing disparities across groups, length-of-life inequality has decreased for the population as a whole and for most education groups, and the contribution of the between-group component of inequality to overall inequality has been extremely small. Even if between-group inequality has increased over time, its contribution has been too small to have sizable effects on overall inequality. In addition, our results suggest that education expansion and declining within-group variability might have been the main drivers of overall lifespan inequality reductions. Nevertheless, the diverging trends in longevity and lifespan inequality across education groups represent an important phenomenon whose underlying causes and potential implications should be investigated in detail.
Industry type and environmental policy: Industry characteristics shape the potential for policymaking success in energy and the environment
Authors: Kelsey Nina 
Published: October 2018

AbstractWhen can complex multi-round environmental policymaking like that seen in climate be successful? An emerging branch of literature examines how sequencing matters to success and under what circumstances path dependent dynamics can lead to increasingly stringent climate and environmental policy. Here, I propose an industry typology that divides industry into four categories based on their relationship and likely response to early regulatory policy moves. I use a series of case studies that compare the application of this typology across issue areas internationally, looking comparatively at ozone and climate change policymaking; and subnationally across U.S. states in the climate change issue area. Using these case studies, I show how this model for understanding different mixes of industry type can help us understand and predict the likelihood of policy-industry feedback that leads to increasing environmental and renewable energy policy success over time, both at the international level and comparatively across national and sub-national jurisdictions.