bluuebunny/crossref_metadata_2025_split huggingface dataset:
Samuel Beckett e Stan Douglas: aproximações pontuais
Authors: Benetti Liliane 
Published: June 2019

Este texto parte de pistas deixadas em Goodbye Pork-Pie Hat (1988), ensaio do artista visual canadense Stan Douglas sobre Film e as peças para televisão de Samuel Beckett, e pretende discutir a recorrência de alguns procedimentos beckettianos na produção de Douglas, especialmente nas séries Television Spots (1987-88) e Monodramas (1991). Palavras-chave: Samuel Beckett; peças para TV; artes visuais contemporâneas; multimídia Abstract: This short text has as its starting point some clues left in Goodbye Pork-Pie Hat (1988), essay by Canadian visual artist Stan Douglas on Film and TV pieces by Samuel Beckett, and aims to discuss the recurrence of Beckett’s procedures in Douglas's production, especially in Television Spots (1987-88) and Monodramas (1991).Keywords: Samuel Beckett; television pieces; contemporary visual arts; multimedia
Quando Beckett falha pior: No’s Knife, adaptação para o palco de Textos para nada
Authors: Do Amarante Dirce Waltrick 
Published: June 2019

Este ensaio focaliza as relações entre a palavra escrita e o palco. Dentre os aspectos estudados, destacamos No’s Knife, uma seleção de Texts for Nothing (tradução de Textes pour rien), de Samuel Beckett, concebida e encenada pela renomada atriz irlandesa Lisa Dwan.Palavras-chave: Samuel Beckett; Lisa Dwan; palavra; palco; performance. Abstract: This paper discusses the relationship between written words and the stage. Amongst the aspects presented in the text, the most relevant one is the proccess of making No’s Knife (a selection of Samuel Beckett’s Texts for Nothing), conceived and performed by the renowed Beckett interpreter Lisa Dwan.Keywords: Samuel Beckett; Lisa Dwan; written word; stage; performance.
"É preciso continuar" - Caminhos da ficção de Beckett em sua tentativa de seguir adiante
Authors: Gonçalves Lívia Bueloni 
Published: June 2019

A prosa de Beckett caracteriza-se por um embate entre a insatisfação com o ato de narrar e a necessidade de seguir adiante. Concentrando-se principalmente na passagem da segunda para a terceira fase da ficção do autor, o artigo reflete sobre as mutações do narrador beckettiano. Entre elas, destaca-se o desenvolvimento do expediente da voz – de instância perturbadora em O inominável e nos Textos para nada a narradora assumida em Companhia.Palavras-chave: Samuel Beckett; prosa beckettiana; narrador; voz; Companhia Abstract: Beckett’s fiction is characterized by a struggle between the dissatisfaction with the act of narrating and the need to move on. Focusing mainly in the passage from the second to the third phase of his fiction, this article reflects upon Beckettian narrator’s mutations. Among them, the development of “the voice” is highlighted – from a disturbing device in The Unnamable and Texts for nothing to a recognized narrator in Company.Keywords: Samuel Beckett; Beckettian fiction; narrator; voice; Company.
Bakhtin e Vygotsky: tecendo as bases para o letramento jurídico
Authors: Emiliano Gonzaga Silvia Regina , Jung Neiva Maria 
Published: June 2019

Tendo em vista a importância dos Novos Estudos de Letramento como campo epistemológico para as discussões do ensino de língua materna, o objetivo deste artigo é discutir a respeito da necessidade do letramento jurídico na disciplina Linguagem Forense para alunos do 1º ano do curso de Direito em uma faculdade particular, uma vez que no contexto jurídico utiliza-se linguagem específica, como os brocardos e expressões latinas, que encerram diversos conceitos básicos dessa área de conhecimento, mas numa linguagem que não é conhecida por boa parte dos alunos que ingressa na vida acadêmica do curso de Direito. Assim, ancorados nos pressupostos bakhtinianos, vygotskyanos, nos Novos Estudos de Letramento e em autores, professores e advogados da esfera do Direito, partimos da exposição e análise do plano de ensino da disciplina Linguagem Forense e, nele, os conteúdos previstos anualmente e os definidos para o 3º bimestre, quando os alunos estudam a linguagem técnica, com a qual precisam familiarizar-se para compreender e desenvolver de forma adequada os textos que serão seus instrumentos de trabalho e estudo no decorrer do Curso e na sua vida profissional.
Factors That Influence Bone-Ingrowth Fixation of Press-Fit Acetabular Cups
Authors: Wiznia Daniel H. , Schwarzkopf Ran , Iorio Richard , Long William J. 
Published: June 2019

» In order to obtain long-term osseointegration, a press-fit acetabular cup must gain initial rigid stability with limited micromotion. In addition, the implant surface must promote ingrowth and maintain contact with viable bone.» Two-dimensional (2D) ongrowth surfaces that have been plasma-spray-coated (heated titanium alloy powder that is flame-sprayed on the substrate) and blasted with grit (surface roughness 4 to 6 µm) achieve fixation via bone interlocking into irregularities in the surface of the implant. Tridimensional ingrowth surfaces, such as titanium fiber mesh (titanium fiber diffusion-bonded to the substrate) and sintered cobalt-chromium and titanium beads, yield secure fixation when bone forms in the voids of the 3-dimensional (3D) surface.» Porous metals that mimic the trabeculae of bone and have a modulus of elasticity similar to bone have higher coefficients of friction than older designs and have demonstrated excellent osteoconductive properties. Not only do these highly porous 3D ingrowth surfaces have a high coefficient of friction, they have demonstrated higher initial stability compared with 2D ongrowth surfaces and older 3D ingrowth surface designs.» Acetabular cups promote biologic fixation with various tridimensional metal surfaces. Materials including porous Trabecular Metal (Zimmer Biomet) have been proven to achieve good osseointegration in patients with poor host bone, including patients with previous radiation exposure, osteonecrosis, or metabolic bone disease, or those who are undergoing revision surgery.
Propuesta de implementación del marco Universal Design for Learning usando narrativas transmedia
Authors: Pineda Acero Julia , Valetts Laura Mancera , Baldiris Navarro Silvia , Rivera Franco Olga , López Martínez Javier 
Published: June 2019

La implementación de estrategias pedagógicas para proveer prácticas educativas inclusivas representa una tarea difícil para los docentes, por ello, con el fin de minimizar la complejidad de dicha inclusión este artículo propone dos estrategias: la primera orientada hacia implementación del marco de trabajo Universal Design for Learning (UDL), que ofrece al docente insumos y mecanismos de relación de la información recolectada para facilitar la identificación de barreras en el currículo y generar soluciones de acuerdo a las plantillas que propone el UDL; y la segunda, basada en los fundamentos transmediales en la educación, que permiten utilizar con sentido interactivo las tecnologías digitales para expandir el conocimiento a partir de narrativas difundidas desde múltiples medios y plataformas, logrando abordar diversas formas de aprendizaje y facilitando la elaboración de la plantilla tres del UDL. El resultado de esta implementación conjunta es un grupo de posibilidades transmediales que permiten discernir la puesta en marcha de un contenido inclusivo desde diferentes medios y múltiples plataformas.
Tamoxifen in Duchenne muscular dystrophy (TAMDMD): study protocol for a multicenter, randomized, placebo-controlled, double-blind phase 3 trial
Authors: Nagy Sara , Hafner Patricia , Schmidt Simone , Rubino-Nacht Daniela , Schädelin Sabine , Bieri Oliver , Fischer Dirk 
Published: June 2019

Abstract
BACKGROUND

Duchenne muscular dystrophy (DMD) is an inherited neuromuscular disorder of childhood with a devastating disease course. Several targeted gene therapies and molecular approaches have been or are currently tested in clinical trials; however, a causative therapy is still not available and best supportive care is limited to oral glucocorticoids with numerous long-term side effects. Tamoxifen is a selective estrogen receptor regulator, and shows besides its antitumor activity also antioxidant actions and regulatory roles in the calcium homeostasis. In a mouse model of DMD, oral tamoxifen significantly improved muscle strength and reduced muscle fatigue. This multicenter, randomized, double-blind, placebo controlled phase 3 trial aims to demonstrate safety and efficacy of tamoxifen over placebo in pediatric patients with DMD. After completion of the double-blind phase, an open label extension of the study will be offered to all participants.

METHODS/DESIGN

At least 71 ambulant and up to 20 non-ambulant patients with DMD are planned to be enrolled at multiple European sites. Patients will be randomly assigned to receive either tamoxifen 20mg or placebo daily over 48 weeks. In the open-label extension phase, all patients will be offered to receive tamoxifen for further 48 weeks. The primary endpoint of the double-blind phase is defined as the change of the D1 domain of the motor function measure in ambulant patients or a change of the D2 domain in non-ambulant patients under tamoxifen compared to placebo. Secondary outcome measures include change in timed function tests, quantitative muscle testing, and quantitative MRI of thigh muscles. Laboratory analyses including biomarkers of tamoxifen metabolism and muscle dystrophy will also be assessed.

DISCUSSION

The aim of the study is to investigate whether tamoxifen can reduce disease progression in ambulant and non-ambulant DMD patients over 48 weeks. Motor function measure comprises the primary endpoint, whereas further clinical and radiological assessments and laboratory biomarkers are performed to provide more data on safety and efficacy. An adjacent open label extension phase is planned to test if earlier initiation of the treatment with tamoxifen (verum arm of double blind phase) compared to a delayed start can reduce disease progression more efficiently.
Can clinical risk factors predict functional recovery in ischemic stroke patients with pre-stroke depression?
Authors: Wormack Leah , Blum Brice , Bailes Benjamin , Nathaniel Thomas 
Published: June 2019

Abstract
Background. Specific clinical risk factors that may be associated with ambulatory outcome following thrombolysis therapy in ischemic stroke patients with pre-stroke depression is not fully understood. This was investigated.

Methods. Multivariate analyses were performed to identify predictors of functional ambulatory outcomes. Patient demographics and clinical risk factors served as predictive variables, while improvement or no improvement in ambulatory outcome was considered as the primary outcome.
Results. A total of 595 of these patients received rtPA of which 310 patients presented with pre-stroke depression, 217 had no improvement in functional outcome, while 93 patients presented with an improvement in functional outcome. Carotid artery stenosis (OR= 11.577, 95% CI, 1.281 – 104.636, P=0.029) and peripheral vascular disease (OR= 18.040, 95% CI, 2.956-110.086, P=0.002) were more likely to be associated with an improvement in ambulation. Antihypertensive medications (OR= 7.810, 95% CI, 1.401 –43.529, P=0.019),previous TIA (OR= 0.444, 95% CI, 0.517 –0.971, P=0.012), and congestive heart failure (OR= 0.217, 95% CI, 0.318 –0.402, P=0.030) were associated with a no improvement in ambulation.
Conclusion. After adjustment for covariates, more clinical risk factors were associated with no improvement when compared with improvement in functional outcome following thrombolysis therapy in an acute ischemic stroke population with pre-stroke depression.
Adaptation and Validation of a Spanish version of the Treatment Burden Questionnaire in Patients with Multiple Sclerosis
Authors: Ysrraelit Maria Celica , Fiol Marcela Paula , Peña Fernando Vazquez , Vanotti Sandra , Terrasa Sergio Adrián , Tran Viet Thi , Montori Victor M , Correale Jorge 
Published: June 2019

Abstract
Background: The Treatment Burden Questionnaire (TBQ) is a self-reported measure of the effect of treatment workload on patient wellbeing. We sought to validate the TBQ in Spanish and use it to estimate the burden of treatment in Argentinian patients with multiple sclerosis (MS).
Methods: The TBQ was forward-backward translated into Spanish. Two focus groups and 25 semi-structured interviews focused on wording and possible item exclusion. Validation was performed in 2 steps. First, 162 patients across a range of MS severity completed the questionnaire. Confirmatory factor analysis assessed the dimensional structure of the TBQ. Construct validity was assessed by studying correlations with fatigue and quality of life (QoL). Then, in a second cohort of 171 patients, we evaluated the association between TBQ scores and patients’ sex, age, education level, employment status, type of MS, disease duration, comorbidities, EDSS, pharmacological treatment and medication adherence.
Results: The questionnaire presented a 3-factor structure in which burden was related to pharmacological treatment; comprehensive health assistance; and psycho-social-economic context. Composite reliability was > 0.8 for all factors. TBQ showed positive correlation with fatigue (rs= 0.467, p=0.006), negative correlation with QoL (rs -0.446, p=0.009). For the second cohort, total TBQ score was 43 (SD 29). Lowest scores were observed on self-monitoring (0.53, SD 1.3) and highest for administrative load (4.2, SD 3.4). Inverse association was found between the TBQ score and medication adherence (r 0.243 p=0.001). TBQ scores also correlated with daily patient pill/injection requirements (r 0.175 p=0.020). Individuals receiving injectable treatment scored higher than patients on oral drugs (total TBQ 51 (SD 32) vs 39 (SD 27) p=0.002).
Conclusions: The TBQ in Spanish is a reliable instrument and showed adequate correlation with QoL and adherence scales in MS patients. TBQ may benefit health resources allocation and provide tailor therapeutic interventions to construct a minimally disruptive care.
Long non-coding RNA MEG3 alters neuronal apoptosis and is associated with poor prognosis in ischemic stroke: based on basic and prospective studies
Authors: Wang Meiping , Chen Wenjuan , Geng Yu , Xu Chenghua , Tao Xiaoxiao , Zhang Yi 
Published: June 2019

Abstract
Background: Ischemic stroke (IS) is a highly heterogeneous disease with variable pathogenesis. Due to the lack of early predictive markers, the mortality rate of IS remains high worldwide. This study focused on the expression pattern of long non-coding RNA (lncRNA) maternally expressed gene 3 (MEG3) and its prognostic value in IS.
Methods: Twenty-four ICR mice (30-35g, 12 males and 12 females) were involved in this study. Middle cerebral artery occlusion (MCAO) was established to simulate an IS environment. Oxygen-glucose deprivation/reoxygenation (OGD/R) in cells were also performed. A total of 215 IS patients and 153 age and gender-matched controls were included. Quantitative Real-time PCR (qRT-PCR) was performed to detect the expression of MEG3 in peripheral blood leukocytes.
Results: The MEG3 expression in MCAO group was significantly higher than control group (P=0.004), and the survival time of high MEG3 group was significantly lower than that of the low MEG3 group (P=0.042). OGD/R promotes cell apoptosis, while si-MEG3 inhibits apoptosis. Results of WB showed that, expression level of Bax was down regulated by si-MEG3, while OGD/R increased its expression level. MEG3 was significantly up-regulated in IS patients and associated with the National Institutes of Health Stroke Scale (NIHSS) (r=0.347, P<0.001), modified Rankin Scale (mRS) (r=0.385, P<0.001), high sensitivity C-reactive protein (Hs-CRP) (r=0.221, P=0.002) level and infarct volume (r=0.201, P=0.006). Overall survival analysis showed that patients with higher MEG3 expression had a relatively poor prognosis (P<0.001). Meanwhile, multivariate analysis revealed that MEG3 was an independent prognostic marker of functional outcome and death in patients with IS.
Conclusions: Current study suggested that MEG3 might be considered as a potential prognostic indicator in IS.
Wheat phyllosphere yeasts degrade propiconazole
Authors: Kucharska Katarzyna , Wachowska Urszula , Czaplicki Sylwester 
Published: June 2019

Abstract
Background: Yeasts, which are ubiquitous in agroecosystems, are known to degrade various xenobiotics. The aim of this study was to analyze the effect of fungicides on the abundance of natural yeast communities colonizing winter wheat leaves, to evaluate the sensitivity of yeast isolates to fungicides in vivo, and to select yeasts that degrade propiconazole.
Results: Fungicides applied during the growing season generally did not affect the counts of endophytic yeasts colonizing wheat leaves. Propiconazole and a commercial mixture of flusilazole and carbendazim decreased the counts of epiphytic yeasts, but the size of the yeast community was restored after 10 days. Epoxiconazole and a commercial mixture of fluoxastrobin and prothioconazole clearly stimulated epiphyte growth. The predominant species isolated from leaves were Aureobasidium pullulans and Rhodotorula glutinis. In the disk diffusion test, 14 out of 75 yeast isolates were not sensitive to any of the tested fungicides. After 48 hours of incubation in an aqueous solution of propiconazole, the Rhodotorula glutinis Rg 55 isolate degraded the fungicide in 85%. Isolates Rh. glutinis Rg 92 and Rg 55 minimized the phytotoxic effects of propiconazole under greenhouse conditions. The first isolate contributed to an increase in the dry matter content of wheat seedlings, whereas the other reduced the severity of chlorosis.
Conclusion: Not sensitivity of many yeast colonizing wheat leaves on the fungicides and the potential of isolate Rhodotorula glutinis Rg 55 to degrade of propiconazole was established. Yeast may partially eliminate the ecologically negative effect of fungicides.
Keywords: wheat leaves, fungicide, Aureobasidium, Rhodotorula.
Microorganisms involved in Deep Neck Infection (DNIs) in Greece: detection, identification and susceptibility to antimicrobials
Authors: Beka Despoina , Lachanas Vasileios A. , Doumas Stergios , Xytsas Stelios , Kanatas Anastasios , Petinaki Efi , Skoulakis Charalampos E. 
Published: June 2019

Abstract
Background

To determine, from October 2010 to October 2018, the epidemiology of Deep Neck Infections (DNIs), regarding the detection, the identification and the susceptibility to antimicrobials of causative microorganisms, in Thessaly-Central Greece.

Methods

An analysis of data from a prospective database was conducted on 610 consecutive patients with DNIs treated in the Otolaryngology / Head & Neck Surgery Department of University Hospital of Larissa. Demographics, clinical features and microbiological data were analyzed.

Results

Among the 610 patients (1,9/1 male to female ratio, mean age: 39,24±17,25) with DNIs, 584 had a single space (95,7%), while the remaining had a multi-space (4,3%) DNI. The most common areas affected were the peritonsillar space (84,6%) followed by the submandibular space (6,5%). Clinical samples were obtained in 462 patients, and were tested by culture and by the application of 16S rRNA PCR. One hundred fifty-five samples (55,2%) gave positive cultures, in which Streptococcus pyogenes and Staphylococcus aureus were predominant. The application 16S rRNA PCR revealed that 183 samples (39,6%) were positive for bacterial DNA; 22 of them were culture negative and were positive for anaerobic (Fusobacterium necrophorum, Actinomyces israellii etc) and for fastidious microorganisms (Brucella mellitensis, Mycobacterium avium).

Conclusion

DNIs represent a medical and surgical emergency and evidence-guided empirical treatment with intravenous infusion of antibiotics at the time of diagnosis is mandatory, highlighting the importance of epidemiological studies regarding the causative microorganisms. Although, in our study, the predominant pathogens were S. pyogenes and S. aureus, the combination of culture and molecular assay revealed that anaerobic bacteria play also a significant role in the pathogenesis of DNIs.
Therapeutic drug monitoring of infliximab compared to standard clinical treatment with infliximab: study protocol for a randomised, controlled, open, parallel-group, phase IV study (The NOR-DRUM study)
Authors: Syversen Silje Watterdal , Goll Guro Løvik , Jørgensen Kristin Kaasen , Olsen Inge Christoffer , Sandanger Øystein , Gehin Johanna Elin , Warren David John , Sexton Joseph , Mørk Cato , Jahnsen Jørgen , Kvien Tore Kristian , Bolstad Nils , Haavardsholm Espen A. 
Published: June 2019

Abstract
Background

Infliximab (INX) and other TNF-inhibitors (TNFi) have revolutionised the treatment of several immune mediated inflammatory diseases. Still, many patients do not respond sufficiently to therapy or loose efficacy over time. The large individual variation in serum drug concentrations on standard doses and the development of anti-drug antibodies are thought to be major reasons for treatment failures. Therapeutic drug monitoring (TDM), an individualised treatment strategy based on systematic assessments of serum drug concentrations, has been proposed as a clinical tool to optimise efficacy of INX treatment. TDM seems reasonable both from a clinical and an economical point of view, but the effectiveness of this treatment strategy has not yet been demonstrated in randomised clinical trials. The NORwegian DRUg Monitoring study (NOR-DRUM) aims to assess the effectiveness of TDM, both with regard to achieve remission in patients starting INX treatment (part A) as well as to maintain disease control in patients on INX treatment (part B).

Methods

The NOR-DRUM study is a randomised, open, controlled, parallel-group, comparative, multi-centre, national, superiority, phase IV study with two separate parts, NOR-DRUM A and NOR-DRUM B. Patients with rheumatoid arthritis, psoriatic arthritis, spondyloarthritis, ulcerative colitis, Crohn’s disease and psoriasis are included. In both study parts participants are randomised 1:1 to either TDM of infliximab (intervention group) or to standard treatment with infliximab without knowledge of drug levels or ADAb status (control group). 400 patients starting INX therapy will be included in NOR-DRUM A. The primary outcome is remission at 30 weeks. In NOR-DRUM B, 450 patients on maintenance treatment with INX will be included. The primary endpoint is occurrence of disease worsening during the 52 weeks study period.

Discussion

As the first trial to assess the effectiveness, safety and cost-effectiveness of TDM in patients receiving TNFi for a range of immune mediated inflammatory diseases, we hope that the NOR-DRUM study can contribute to the advancement of evidence based personalised treatment with biological medicines.