bluuebunny/crossref_metadata_2025_split huggingface dataset:
Spatial-typological structure of blackflies communities (Diptera: Simuliidae) of the River Tisa basin within of the Ukrainian Carpathians
Authors: Tepliuk A. M. , Sukhomlin K. B. 
Published: February 2019

A total of 46 species of blackflies from 2 genera were recorded in the watercourses of the Tisa River basin within Ukrainian Carpathians. In qualitative terms, the genus Simulium Latreille, 1802 predominates, with 42 species in 5 subgenera: Nevermannia Enderlein, 1921 (9 species), Eusimulium Roubaud, 1906 (2 species), Wilhelmia Enderlein, 1921 (4 species), Obuchovia Rubtsov, 1947 (2 species) and Simulium Latreille, 1802 (25 species). The genus Prosimulium Roubaud, 1906 is represented with only 4 species. Moreover, 33 species develop in streams (the index of the species diversity of Simpson (Is) is 0,094), and 32 species (Is – 0,087) of Simuliidae develop in rivers. There are 19 common species for both types of watercourses (the index of similarity of Chekanovsky-Sorensen (I) is 0.37). Only 14 species of blackflies develop in streams, and only 13 species develop in rivers. Two dominant species (S. (s.str.) intermedium, S. (s.str.) trifasciatum) and 4 subdominant species (S. (s.str.) argyreatum, S. (s.str.) ornatum, S. (s.str.) reptans, S. (s.str.) variegatum) form the nucleus of the fauna Simuliidae of the Tisa River basin. The species diversity of blackflies reaches 33 species (Is – 0,075) at watercourses of the low mountain level (at altitudes up to 499 m), is has 38 species (Is – 0,067) at the middle mountain level (500–999 m) and only 24 species (Is – 0,021) at high mountain level (above 1000 m). Only 6 species (S. (Eusimulium) velutinum, S.(Obuchovia) brevifile, S. (s.str.) noelleri, S. (s.str.) rostratum, S. (s.str.) tuberosum and S. (s.str.) voilense) develop in the watercourses of the low mountain level, 5 blackfly species (S. (Nevermannia) codreanui, S. (Wilhelmia) pseudoequinum, S. (s.str.) argenteostriatum, S. (s.str.) paramorsitans and S. (s.str.) vulgare) develop in the watercourses of the middle mountain level and 2 species blackflies (S. (Nevermannia) crenobium and S. (Nevermannia) oligotuberculatum) develop in the watercourses of the high mountain level. There are 16 species of Simuliidae common for this high altitude belts, among them S. (Nevermannia) vernum, S. (s.str.) fontanum, S.(s.str.) intermedium, S.(s.str.) ornatum and S. (s.str.) trifasciatum did not reveal the definite patterns of belonging to the specific altitudes, since their quantity was approximately the same at different heights.
Problematic video game use as an emotional coping strategy: Evidence from a sample of MMORPG gamers
Authors: Blasi Maria Di , Giardina Alessandro , Giordano Cecilia , Coco Gianluca Lo , Tosto Crispino , Billieux Joel , Schimmenti Adriano 
Published: February 2019

Background
A positive relationship between problematic gaming and escapism motivation to play video games has been well established, suggesting that problematic gaming may result from attempts to deal with negative emotions. However, to date, no study has examined how emotion dysregulation affects both escapism motives and problematic gaming patterns.

Methods
Difficulties in emotion regulation, escapism, and problematic involvement with video games were assessed in a sample of 390 World of Warcraft players. A structural equation modeling framework was used to test the hypothesis that escapism mediates the relationship between emotion dysregulation and problematic gaming.

Results
Statistical analyses showed that difficulties in emotion regulation predicted both escapism motives and problematic gaming, and that escapism partially mediated this relationship.

Conclusion
Our findings support the view that problematic players are likely to escape in online games as a maladaptive coping strategy for dealing with adverse emotional experiences.
The relationship of plasma catestatin and heart rate variability parameters in middle-aged men with primary hypertension
Authors: Gubareva E. Yu. , Kryukov N. N. , Gubareva I. V. 
Published: February 2019

Aim.To study the catestatin plasma level in patients with primary hypertension of different cardiovascular risk and to assess its relationship with heart rate variability (HRV) parameters.Material and methods. One hundred eighty men aged 30-50 years were divided into groups: group 1 (n=28) — hypertensive patients with medium risk of developing cardiovascular complications (CVC), group 2 (n=76) — hypertensive patients with high risk of CVC, group 3 (n=31) — hypertensive patients with very high risk of CVC. The control group consisted of healthy men with normal blood pressure (BP) (n=45). We determined plasma catestatin (ng/ml) and conducted Holter monitoring.Results.A pattern was found to reduce the concentration of catestatin with increasing risk of CVC in hypertensive patients, but there were no significant differences between the studied groups (p>0,05).We determined corrections between catestatin levels and echocardiography thickness of left ventricular posterior wall (r=-0,523; p=0,045) and interventricular septum (r=-0,523, p=0,045) in diastole in group 2; thickness of left ventricular posterior wall (r=0,258; p=0,035) and interventricular septum (r=0,254; p=0,038) in systole in group 3. In patients of group 2, direct correlations of catestatin levels and sympathicotonia LF/HF were revealed during the whole observation period (r=0,301; p=0,019) and during wakefulness (r=0,308; p=0,019); inverse correlations — with parameters of parasympathetic tone: nHF during the whole observation time (r=-0,318; p=0,013) and during wakefulness (r=-0,342; p=0,007), pNN50 in the afternoon (r=-0,270; p=0,037).Conclusion.A decrease in catestatin concentrations in hypertensive patients is associated with the progression of disease and an increase in cardiovascular risk. It is assumed that catestatin is involved in the formation of HRV in patients with primary hypertension.
PREDICTORS OF ARTERIAL HYPERTENSION IN PATIENTS WITH TYPE 2 DIABETES MELLITUS IN AZERBAIJAN POPULATION
Authors: Mekhdiyev S. Kh. , Mustafaev I. I. , Mamedov M. N. 
Published: February 2019

The presented study in Azerbaijan is carried out for the first time within State Programs on fight against a type 2 diabetes mellitus (DM2) and other noninfectious diseases.Aim.To define predictors of arterial hypertension (AH) in patients with DM2 in Azerbaijan population.Material and methods. In the single-step clinical-epidemiology cohort study were included 528 patients with DM2 at the age of 30-69 (30,5% — men and 69,5% — women) who answered questions using “ARIC” questioner to define AH and its risk factors.Results.The prevalence of AH in women (72,4%) was 2,6 times more than in men (27,6%) and the frequent occurrence of AH was at the age of 60-69 (respectively, 26,7±2,1% vs 9,6±2,9%, p<0,001). It was not determined remarkable differences between AH level and occupation status, alcohol consumption, low physical activity, feeding disorder of the patients, at the same time in patients with AH smoking frequency was about 2 times often than in others (respectively, 19,3±1,9% vs 10,6±3,0%, p<0,05). In parents of AH patients AH rates, in comparison with eutonics, were occurred like these: (respectively, in fathers 21,9±2,0% vs 12,5±3,2%, p<0,05; in mothers 42,2±2,4% vs 26,9±4,3%, p<0,01), in mothers DM2 (respectively, 33,7±2,3% vs 221 ±4,1 %, p<0,05), overweight and obesity were watched much more often (95,0±1,1% vs 88,5±3,1%, p<0,05), at the same time these patients were suffered from abdominal obesity (respectively, 96,5±0,9% vs 89,4±3,0%, p<0,01). The mean values of systolic and diastolic arterial pressure (respectively, 148,3±1,1 vs 119,8±1,3 Hg, p<0,001 and 85,9±0,5 vs 74,8±0,8 Hg, p<0,001) were often determined in patients with AH, and on the other hand in these patients were noted prevalence of anxious syndrome (respectively, 78,5±2,0% vs 72,1±4,4%, p<0,05) and depression (68,2±2,3% vs 62,5±4,7%, p>0,05). Regardless of AH level in all patients was noted stress (respectively, 99,8±0,2% vs 100,0±0,0%, p>0,05), which changed for the worse life quality of the patients with AH significantly (respectively, 1,0±2,2% vs 61,5±4,8%, p<0,05).Conclusion.For patients with DM2 in Azerbaijan cohort female sex, increasing of the age, body mass index, abdominal obesity and anxious conditions are significant risk factors for AH. Presence of AH in both parents and DM2 in mothers increase this risk significantly, which decrease life quality of these patients.
Influence of arterial hypertension, smoking, and their combination on mortality (according to the results of a 27-year cohort prospective study of the unorganized population of Tomsk)
Authors: Dolgalev I. V. , Brazovskaya N. G. , Ivanova A. Yu. , Shipkhineeva A. Yu. , Bogaychuk P. M. 
Published: February 2019

Aim.To study the influence of arterial hypertension (AH), smoking, and their combination on the risk of all cause and cardiovascular mortality.Material and methods. We conducted a 27-year cohort prospective study of the unorganized population of Tomsk (916 women and 630 men aged 20-59 years). At the first stage, we studied the prevalence of AH and smoking (1998-1991), at the second (2015) — the effect of these risk factors (RF) and their combination on the risk of all cause and cardiovascular mortality. AH was diagnosed at a blood pressure level of >140/90 mmHg and <140/90 mm Hg in individuals taking antihypertensive drugs. Smokers were individuals who smoked at least 1 cigarette per day and quit smoking less than one year ago.Results.The study found a significant effect of AH and smoking on mortality: the relative risk (RR) of all-cause mortality in people with hypertension was 2,2, in smokers — 2,3, in those with a combination of RF — 5,0. The RR of cardiovascular mortality in AH individuals was 3,4, in smokers — 1,6, in smoking men and women suffering from AH — 5,2. An increase in the risk of all-cause mortality in people with AH and smoking was observed in all gender-age groups. Smoking was found to increase the risk of all-cause mortality in individuals with high levels of blood pressure by 2,1 times compared with non-smoking hypertensive patients. It reduces the chances of a 27-year survival rate to 64,4%, and more so in the youngest (20-39 years) age group (RR — 3,9). Multivariate analysis showed that AH and smoking make the most significant contribution to the formation of mortality compared to other modifiable RFs.Conclusion.We found that AH and smoking are among the most influential RFs, and their combination increases the RR of all-cause mortality by 5,0 times (cardiovascular — 5,2 times). We also determined an additional risk of smoking in individuals suffering from AH to the all-cause mortality.
Pharmacoeconomic effectiveness of using modern technologies in the follow-up care of patients with arterial hypertension
Authors: Efanov A. Yu. , Medvedeva I. V. , Shalaev S. V. , Petrov I. M. , Yusupova E. Yu. , Volkova S. Yu. , Petrova Yu. A. 
Published: February 2019

Aim. To conduct a pharmacoeconomic assessment of the use of modern technologies in the follow-up care of patients with arterial hypertension (AH) in the Tyumen region.Material and methods. Using a random sampling technique we selected and examined 1704 patients with AH in the Tyumen region. The average age of patients was 62±75 years, 31,5% were men. Patients are divided into active monitoring and control groups. Weekly sms and e-mail messages with prevention information were sent to patients of the active monitoring group. General practitioners receive a course of training seminars on the features of follow-up observation of patients with AH. After 12 months (±3,2), the patients had repeated examination. We conducted pharmacoeconomic analysis of the intervention.Results. The results of our study showed that the total cost of the disease with active follow-up of patients with AH decreases, which mainly occurs due to indirect expenses. Weekly sms and e-mail notification of patients in combination with educational seminars for general practitioners and cardiologists leads to a change in the structure of expenses for the treatment of patients with AH. We noticed reducing the cost of inpatient treatment, emergency calls, and a decrease in indirect expenses. On the other hand, there is a redistribution of funds spent on pharmacotherapy and cases of outpatient visits. Such redistribution, combined with a decrease in the total cost of the disease, leads to savings in the resources of the health care system and allows an additional 231 patients to be treated within 12 months.Conclusion. The proposed model of active follow-up is economically viable, both by reducing the total cost of the disease, and by redistributing funds towards using pharmacotherapy and outpatient visits, which is the most rational in the treatment of AH.
The results of intramyocardial implantation of autologous bone marrow cells treated with erythropoietin in the surgical treatment of coronary artery disease with severe lesion of vessels
Authors: Fomichev A. V. , Chernyavsky A. M. , Gulyaeva K. K. , Poveshchenko O. V. , Lykov A. P. , Kareva Yu. E. , Minin S. M. , Nikitin N. A. 
Published: February 2019

Aim. To assess safety and efficacy of intramyocardial implantation of autologous bone marrow cells treated with erythropoietin in surgery for coronary artery disease (CAD).Materials and methods. Eighty patients with CAD with diffuse and (or) distal lesions of the right coronary artery were randomly assigned to two groups: patients of group 1 (n=40) underwent coronary bypass surgery, implantation of autologous bone marrow cells treated with erythropoietin into the lower wall of the left ventricle, patients of group 2 (control group, n=40) underwent bypass surgery of the left coronary artery. Evaluation of the clinical status, perfusion and contractility of the myocardium was performed initially, 6 and 12 months after surgery.Results. Six months after the operation, we found more pronounced decrease of functional class (FC) of angina and improvement in the 6-min walk distance in the main group compared with the control group.Twelve months after surgery, the severity of angina remained at the same level in both groups. In the control group, 45,2% of patients had FC I, 52,3% of patients did not have angina. In both groups, angina return was detected in 1 patient (FC III). According to the results of two-step myocardial scintigraphy with Technetril (Tc99), 6 months after surgery, a significant improvement in myocardial perfusion was observed. In the control group, after 6 months, no significant dynamics of perfusion of the lower wall of the left ventricle was detected.Twelve months after the surgical treatment of the right coronary artery in patients from the group 1 revealed a decrease in the stress defect and the stable perfusion defect. In patients from the control only a significant stress defect was found to decrease.Conclusion. The study demonstrated decrease of FCs, significant improvement in perfusion, functional state of the myocardium and 6-min walk distance in patients of group 1.
The state of the main arteries, vascular age in patients with arterial hypertension and obesity: the role of leptin and adiponectin
Authors: Statsenko M. E. , Derevyanchenko M. V. 
Published: February 2019

Aim.To study the state of the main arteries and vascular age in conjunction with the level of leptin and adiponectin in patients with arterial hypertension (AH) and obesity.Material and methods. One hundred and twenty patients with AH stage II aged from 45 to 65 years were divided into 3 groups depending on body mass index (BMI). Group 1 was represented by patients with AH and normal BMI, the 2 group was represented by patients with AH and excessive BMI, the 3 group was represented by patients with AH in combination with obesity. A standard clinical examination was performed, the stiffness of the vascular wall was measured by measuring the pulse wave velocity (PWV) of the muscle and elastic vessels (PWVe), vascular age was calculated, and the laboratory markers of obesity were determined.Results.High percentage of visceral obesity was observed: 20,0% among people with normal BMI, 64,4% among overweight people and 100% among people with obesity (differences between 1 and 2, 1 and 3, 2 and 3 groups are reliable). A statistically significant increase in PWVe was detected in patients with AH and obesity in comparison with patients with AH and normal body weight (9,8 [8,5; 11,3] vs 8,0 [79; 8,1] m/s). Vascular age was higher in patients with AH and overweight or obesity compared with patients with AH and normal weight (670 [60,0; 76,0], 68,0 [60,0; 72,0] vs 58,0 [57,0; 60,0] years, respectively). A statistically significant increase in the concentration of leptin (6,9 [4,5; 15,1] vs 19,0 [74; 42,7] vs 53,8 [38,4; 75,8] ng/ml) was detected, as well as a decrease in adiponectin concentration from the 1 to the 3 group (44,9 [36,6; 55,8] vs 16,5 [12,5; 24,7] vs 18,6 [15,3; 22,4] ng/ml, respectively).Correlation analysis revealed the presence of highly reliable relationships between the parameters of rigidity of the main arteries and laboratory markers of obesity.Conclusion.The results indicated a negative effect of hyperleptinemia and hypoadiponectinemia on the elasticity of the vascular wall of the main arteries and the vascular age in hypertensive patients with its combination with overweight or obesity.
Spliced XBP1 Rescues Renal Interstitial Inflammation Due to Loss of Sec63 in Collecting Ducts
Authors: Ishikawa Yasunobu , Fedeles Sorin , Marlier Arnaud , Zhang Chao , Gallagher Anna-Rachel , Lee Ann-Hwee , Somlo Stefan 
Published: February 2019

Significance Statement
CKD of various etiologies manifests with declining kidney function in the setting of progressive interstitial inflammation, with increased myofibroblasts and collagen deposition. In this study, the authors developed a novel genetic model, demonstrating that impairment of protein homeostatic mechanisms in the endoplasmic reticulum of collecting duct cells is sufficient to produce interstitial inflammation, fibrosis, and impaired kidney function. In this model, genes encoding both Sec63, a resident protein in the endoplasmic reticulum membrane, and Xbp1, a transcription factor that is central to the unfolded protein response, were inactivated in the collecting ducts of neonatal mice. The result was progressive macrophage and myofibroblast expansion within 5 weeks and significant progressive kidney dysfunction thereafter. The Sec63-Xbp1 collecting duct knockout mouse offers a novel genetic model for studying chronic tubulointerstitial kidney injury.

Background

SEC63 encodes a resident protein in the endoplasmic reticulum membrane that, when mutated, causes human autosomal dominant polycystic liver disease. Selective inactivation of Sec63 in all distal nephron segments in embryonic mouse kidney results in polycystin-1–mediated polycystic kidney disease (PKD). It also activates the Ire1α-Xbp1 branch of the unfolded protein response, producing Xbp1s, the active transcription factor promoting expression of specific genes to alleviate endoplasmic reticulum stress. Simultaneous inactivation of Xbp1 and Sec63 worsens PKD in this model.

Methods
We explored the renal effects of postnatal inactivation of Sec63 alone or with concomitant inactivation of Xbp1 or Ire1α, specifically in the collecting ducts of neonatal mice.

Results
The later onset of inactivation of Sec63 restricted to the collecting duct does not result in overt activation of the Ire1α-Xbp1 pathway or cause polycystin-1–dependent PKD. Inactivating Sec63 along with either Xbp1 or Ire1α in this model causes interstitial inflammation and associated fibrosis with decline in kidney function over several months. Re-expression of XBP1s in vivo completely rescues the chronic kidney injury observed after inactivation of Sec63 with either Xbp1 or Ire1α.

Conclusions
In the absence of Sec63, basal levels of Xbp1s activity in collecting ducts is both necessary and sufficient to maintain proteostasis (protein homeostasis) and protect against inflammation, myofibroblast activation, and kidney functional decline. The Sec63-Xbp1 double knockout mouse offers a novel genetic model of chronic tubulointerstitial kidney injury, using collecting duct proteostasis defects as a platform for discovery of signals that may underlie CKD of disparate etiologies.
ВЛИЯНИЕ ПРИМЕСИ L,α-АЛАНИНА НА СПОНТАННУЮ ЭВОЛЮЦИЮ ДОМЕННОЙ СТРУКТУРЫ ТРИГЛИЦИНСУЛЬФАТА ВБЛИЗИ ТОЧКИ КЮРИ
Authors: Golitsyna Olga M. , Drozhdin Sergey N. , Lesnikova Valeriya O. 
Published: February 2019

Методом атомной силовой микроскопии в режиме пьезоотклика изучена эволюция неравновесной доменной структуры кристаллов чистого триглицинсульфата (ТГС) и с примесью L,α-аланина (АТГС) вблизи температуры фазового перехода ТС в температурном интервале ΔТС = ТС−Т = 1 К. В обоих кристаллах экспоненциально уменьшаются со временем общее число доменов N и полный периметр доменных границ L, диэлектрическая проницаемость ε, измеренная в слабом переменном электрическом поле. Изрезанность доменных границ в кристалле АТГС сохраняется с течением времени, приводя к росту значений среднего периметра домена L / N. Средняя скорость спонтанного бокового движения доменных границ в кристалле АТГС меньше чем в ТГС из-за демпфирующего действия дефектов. Вблизи ТС оба кристалла являются открытыми системами с неконсервативным параметром порядка, и развитие доменной структуры происходит с изменением поверхностного заряда. При удалении от ТС состояние с сохраняющимся параметром порядка достигается быстрее в дефектном кристалле АТГС.
КРИСТАЛЛИЗАЦИЯ КВАЗИБИНАРНОЙ ЭВТЕКТИКИ bnss-tss В СИСТЕМЕ Cu-Fe-Ni-S
Authors: Sinyova Svetlana I. , Kosyakov Victor I. , Sinyakova Elena F. , Novoghilova Olga S. 
Published: February 2019

Исследование посвящено изучению процессов зональной кристаллизации в четырехкомпонентной системе Cu-Fe-Ni-S, являющейся базовой при формировании медно-никелевых сульфидных руд. Образец исходного состава (мол. %): Cu = 17.19, Fe = 19.05, Ni = 19.66, S = 44.10 синтезирован с применением метода квазиравновесной направленной кристаллизации. Результаты микроскопического исследования показали, что полученный слиток образован из 6 зон с разным фазовым и химическим составом. Основная часть слитка представлена зоной IV. Образцы, вырезанные из этой зоны, исследовались методами дифференциального термического анализа (ДТА), растровой электронной микроскопии (СЭМ) и рентгено-спектрального микроанализа (РСМА). Микроскопические исследования позволили предположить, что слиток состоит из твердых растворов tss и bnss, но при дальнейшем охлаждении tss разложился на дочерние фазы. Однако эти данные можно трактовать и как кристаллизацию четверной эвтектики. Результаты ДТА исследования образцов позволили измерить температуры фазовых эффектов и однозначно установить образование бинарной эвтектики bnss-tss. Температура бинарной эвтектики (L → tss + bnss) составляет 578±1 °С (851±1 K). Температуры ликвидуса незначительно повышаются от 857±2 °С до 862±2 °С (1130±2 K - 1135±2 K). Указанное изменение объясняется небольшими изменениями состава исследуемых образцов. Полученные результаты подтвердили адекватность и согласованной предложенной методики, сочетающей методы направленной кристаллизации, дифференциального термического анализа, растровой электронной микроскопии и рентгеноспектрального микроанализа при исследовании фазовых равновесий в многокомпонентных системах.

Исследование выполнено в рамках госзадания (проект 0330-2016-0001) и при частичной финансовой поддержке комплексной программы фундаментальных научных исследований СО РАН II.1. № 303.