bluuebunny/crossref_metadata_2025_split huggingface dataset:
Perioperative and Long-term Oncological Results of Minimally Invasive Pancreatoduodenectomy as Hybrid Technique – A Matched Pair Analysis of 120 Cases
Authors: Deichmann Steffen , Bolm Louisa , Honselmann Kim , Wellner Ulrich , Lapshyn Hryhoriy , Keck Tobias , Bausch Dirk 
Published: May 2018

Abstract
Background Laparoscopic pancreatoduodenectomy is a highly challenging procedure. The aim of this study was to analyse post-operative morbidity and mortality as well as long term overall survival in patients undergoing hybrid LPD, as compared to open pancreaticoduodenecomy (OPD) in a single surgeon series.
Methods Patients undergoing pancreatoduodenectomy (PD) in the period from 2000 to 2015 were identified from a prospectively maintained database. All LPD procedures were performed by one specialised pancreatic surgeon (TK). Patients were matched 1 : 1 for age, sex, BMI, ASA, histological diagnosis, pancreatic texture and portal venous resection (PVR). All LPD procedures were performed as hybrid LPD – combining laparoscopic resection and open reconstruction via mini laparotomy.
Results A total of 549 patients were identified, including 489 patients in the OPD group and 60 patients in the LPD group. 60 patients were identified who underwent LPD between 2010 and 2015 versus 60 OPD patients operated in the same period. Median overall operation time was shorter in the LPD group than with OPD patients (LPD 352 vs. OPD 397 min; p = 0.002). Overall transfusion units were lower in the LPD group (LPD range 0 – 4 vs. OPD range 0 – 11; p = 0.032). Intensive care unit stay (LPD 1 vs. OPD 6 d; p = 0.008) and overall hospital stay (OHS: LPD 14 vs. OPD 18 d; p = 0.012) were shorter in the LPD groups than in the OPD group. As regards postoperative complications, LPD was associated with reduced rates of clinically relevant grade B/C postoperative pancreatic fistula (LPD 15 vs. OPD 36%; p = 0.036) and grade B/C delayed gastric emptying (LPD 8 vs. OPD 20%; p = 0.049). A total of 56 patients were diagnosed with malignant disease. The number of harvested lymph nodes and R0-resection rates were equal for LPD and OPD patients. LPD patients showed a trend to improved median overall survival (LPD mean 56 months vs. OPD mean 48 months; p = 0.056).
Conclusion Hybrid LPD is a safe procedure associated with a reduction in clinically relevant postoperative complications and allows faster recovery. Long term oncological outcome of hybrid LPD for malignant disease is equal to that with the standard open approach.
Monomial basis in Korenblum type spaces of analytic functions
Authors: Bonet José , Lusky Wolfgang , Taskinen Jari 
Published: May 2018

It is shown that the monomials

Λ
=
(

z
n

)

n
=
0

∞

\Lambda =(z^n)_{n=0}^{\infty }

are a Schauder basis of the Fréchet spaces

A
+

−
γ

,

γ
≥
0
,

A_+^{-\gamma }, \ \gamma \geq 0,

that consists of all the analytic functions

f
f

on the unit disc such that

(
1
−

|

z

|

)

μ

|

f
(
z
)

|

(1-|z|)^{\mu }|f(z)|

is bounded for all

μ
>
γ

\mu > \gamma

. Lusky proved that

Λ
\Lambda

is not a Schauder basis for the closure of the polynomials in weighted Banach spaces of analytic functions of type

H

∞

H^{\infty }

. A sequence space representation of the Fréchet space

A
+

−
γ

A_+^{-\gamma }

is presented. The case of (LB)-spaces

A

−

−
γ

,

γ
>
0
,

A_{-}^{-\gamma }, \ \gamma > 0,

that are defined as unions of weighted Banach spaces is also studied.
Correction to “On some subspaces of Banach spaces whose duals are 𝐿₁ spaces”
Authors: Zippin M. 
Published: May 2018

E. Casini, E. Miglierina, L. Piasecki, and L. Veselý have recently constructed an example of an

L

1

L_{1}

-predual hyperplane

W
W

of

c
c

which does not contain a subspace isometric to

c
c

, in spite of the fact that the closed unit ball of

W
W

contains an extreme point. This example shows that Remark A of Section 4 of [Proc. Amer. Math. Soc. 23 (1969), pp. 378-385], titled as above, is false. The purpose of this note is to present two correct versions of that Remark A and a short proof of our 1969 main result.
Blockade of TLR4 Within the Paraventricular Nucleus Attenuates Blood Pressure by Regulating ROS and Inflammatory Cytokines in Prehypertensive Rats
Authors: Wang Mo-Lin , Yu Xiao-Jing , Li Xiao-Guang , Pang De-Zhi , Su Qing , Saahene Roland Osei , Li Hong-Bao , Mao Xu-Ying , Liu Kai-Li , Fu Li-Yan , Li Ying , Zhu Guo-Qing , Kang Yu-Ming 
Published: May 2018

Abstract

BACKGROUND
Toll-like receptor 4 (TLR4) has been implicated in the progression of cardiovascular disease, including hypertension. However, the role of TLR4 in the development of prehypertension is uncertain.

METHODS
Prehypertensive rats were treated with 8% salt for 12 weeks to induce prehypertension. These rats were then given either TAK-242 selective TLR4 blocker, or vehicle by bilateral micro-injection to the paraventricular nucleus (PVN). Blood pressure (BP) and renal sympathetic nerve activity were recorded. PVN expression of TLR4, myeloid differentiation factor 88 (Myd88), nuclear factor-kappa B (NF-κB) p65, proinflammation cytokines (PICs), interleukin (IL)-1β, IL-6, tumor necrosis factor-alpha (TNF-α), nicotinamide adenine dinucleotide phosphate (NADPH) oxidase 2 (NOX2), NADPH oxidase 4 (NOX4), Cu/Zn superoxide dismutase (SOD) level, tyrosine hydroxylase, and 67 kDa isoform of glutamate decarboxylase (GAD67) were tested to determine the influence of TLR4 blockade.

RESULTS
TLR4 expression increased significantly in the PVN of high-salt groups with a corresponding increase in reactive oxygen species (ROS) and PICs. TLR4 blockade significantly reduced the signaling molecules downstream TLR4 and the expression of TNF-α, IL-6, IL-1β, decreased ROS, NOX2, NOX4 level, increased Cu/Zn-SOD, re-balanced neurotransmitters, and regulated sympathetic nerve activity in the PVN of prehypertensive rats.

CONCLUSIONS
Salt-induced prehypertension is partly due to the upregulation of TLR4 in PVN. Blockade of TLR4 in the brain reduced salt-induced prehypertension response, possibly through downregulation of ROS and PICs expression, and the restorage of neurotransmitter balance in the PVN.
Impact of Blunted Nocturnal Blood Pressure Dipping on Cardiac Systolic Function in Community Participants Not Receiving Antihypertensive Therapy
Authors: Woodiwiss Angela J , Libhaber Carlos D , Sareli Pinhas , Norton Gavin R 
Published: May 2018

Abstract

BACKGROUND
Blunted nocturnal blood pressure (BP) dipping (nondipping) predicts cardiovascular morbidity and mortality, and is associated with heart failure (HF) independent of office BP. Whether nondipping is independently associated with cardiac systolic function prior to the development of HF is uncertain.

METHODS
We assessed whether nocturnal BP dipping pattern and nocturnal BP were associated with indexes of cardiac systolic function [endocardial fractional shortening (endFS), midwall FS (mFS), ejection fraction (EF)] independent of left ventricular mass index (LVMI) and relative wall thickness (RWT) in 491 randomly selected community participants not receiving antihypertensive therapy. Nocturnal BP and dipping pattern were determined from 24-hour BP monitoring where nighttime was defined from fixed-clock time intervals. BP dipping was defined as night-to-day BP ratio. Pulse wave velocity (PWV) was determined using SphygmoCor, and total peripheral resistance (TPR) was calculated from echocardiographic data.

RESULTS
On bivariate analyses, nocturnal BP and BP dipping but not day BP were correlated with indexes of cardiac systolic function (P &lt; 0.005). After adjustments for potential confounders including age, LVMI (or RWT) and 24 hour (or day) BP, endFS (P &lt; 0.01), mFS (P &lt; 0.05), and EF (P &lt; 0.01) were associated with nocturnal BP and BP dipping. These relationships survived further adjustments for PWV, and the homeostasis model of insulin resistance. The decreased mFS in reverse dippers was in-part explained by an increased TPR.

CONCLUSIONS
In an untreated community sample, blunted nocturnal BP dipping is independently and inversely associated with cardiac systolic function. Hence, nondipping is related to a reduced cardiac systolic function prior to the development of HF.
Edge-group sparse PCA for network-guided high dimensional data analysis
Authors: Min Wenwen , Liu Juan , Zhang Shihua 
Published: May 2018

AbstractMotivationPrincipal component analysis (PCA) has been widely used to deal with high-dimensional gene expression data. In this study, we proposed an Edge-group Sparse PCA (ESPCA) model by incorporating the group structure from a prior gene network into the PCA framework for dimension reduction and feature interpretation. ESPCA enforces sparsity of principal component (PC) loadings through considering the connectivity of gene variables in the prior network. We developed an alternating iterative algorithm to solve ESPCA. The key of this algorithm is to solve a new k-edge sparse projection problem and a greedy strategy has been adapted to address it. Here we adopted ESPCA for analyzing multiple gene expression matrices simultaneously. By incorporating prior knowledge, our method can overcome the drawbacks of sparse PCA and capture some gene modules with better biological interpretations.ResultsWe evaluated the performance of ESPCA using a set of artificial datasets and two real biological datasets (including TCGA pan-cancer expression data and ENCODE expression data), and compared their performance with PCA and sparse PCA. The results showed that ESPCA could identify more biologically relevant genes, improve their biological interpretations and reveal distinct sample characteristics.Availability and implementationAn R package of ESPCA is available at http://page.amss.ac.cn/shihua.zhang/Supplementary informationSupplementary data are available at Bioinformatics online.
MICAN-SQ: a sequential protein structure alignment program that is applicable to monomers and all types of oligomers
Authors: Minami Shintaro , Sawada Kengo , Ota Motonori , Chikenji George 
Published: May 2018

Abstract

Motivation
Protein structure alignment is a significant tool to understand evolutionary processes and physicochemical properties of proteins. Important targets of structure alignment are not only monomeric but also oligomeric proteins that sometimes include domain swapping or fusions. Although various protein structural alignment programs have been developed, no method is applicable to any protein pair regardless of the number of chain components and oligomeric states with retaining sequential restrictions: structurally equivalent regions must be aligned in the same order along protein sequences.

Results
In this paper, we introduced a new sequential protein structural alignment algorithm MICAN-SQ, which is applicable to protein structures in all oligomeric states. In particular, MICAN-SQ allows the complicated structural alignments of proteins with domain swapping or fusion regions. To validate MICAN-SQ, alignment accuracies were evaluated using curated alignments of monomers and examples of domain swapping, and compared with those of pre-existing protein structural alignment programs. The results of this study show that MICAN-SQ has superior accuracy and robustness in comparison with previous programs and offers limited computational times. We also demonstrate that MICAN-SQ correctly aligns very large complexes and fused proteins. The present computations warrant the consideration of MICAN-SQ for studies of evolutionary and physicochemical properties of monomeric structures and all oligomer types.

Availability and implementation
The MICAN program was implemented in C. The source code and executable file can be freely downloaded from http://www.tbp.cse.nagoya-u.ac.jp/MICAN/.

Supplementary information
Supplementary data are available at Bioinformatics online.
Recombinational DSBs-intersected genes converge on specific disease- and adaptability-related pathways
Authors: Yang Zhi-Kai , Luo Hao , Zhang Yanming , Wang Baijing , Gao Feng 
Published: May 2018

Abstract

Motivation
The budding yeast Saccharomyces cerevisiae is a model species powerful for studying the recombination of eukaryotes. Although many recombination studies have been performed for this species by experimental methods, the population genomic study based on bioinformatics analyses is urgently needed to greatly increase the range and accuracy of recombination detection. Here, we carry out the population genomic analysis of recombination in S.cerevisiae to reveal the potential rules between recombination and evolution in eukaryotes.

Results
By population genomic analysis, we discover significantly more and longer recombination events in clinical strains, which indicates that adverse environmental conditions create an obviously wider range of genetic combination in response to the selective pressure. Based on the analysis of recombinational double strand breaks (DSBs)-intersected genes (RDIGs), we find that RDIGs significantly converge on specific disease- and adaptability-related pathways, indicating that recombination plays a biologically key role in the repair of DSBs related to diseases and environmental adaptability, especially the human neurological disorders. By evolutionary analysis of RDIGs, we find that the RDIGs highly prevailing in populations of yeast tend to be more evolutionarily conserved, indicating the accurate repair of DSBs in these RDIGs is critical to ensure the eukaryotic survival or fitness.

Supplementary information
Supplementary data are available at Bioinformatics online.
VarExp: estimating variance explained by genome-wide GxE summary statistics
Authors: Laville Vincent , Bentley Amy R , Privé Florian , Zhu Xiaofeng , Gauderman Jim , Winkler Thomas W , Province Mike , Rao D C , Aschard Hugues 
Published: May 2018

Abstract

Summary
Many genome-wide association studies and genome-wide screening for gene–environment (GxE) interactions have been performed to elucidate the underlying mechanisms of human traits and diseases. When the analyzed outcome is quantitative, the overall contribution of identified genetic variants to the outcome is often expressed as the percentage of phenotypic variance explained. This is commonly done using individual-level genotype data but it is challenging when results are derived through meta-analyses. Here, we present R package, ‘VarExp’, that allows for the estimation of the percentage of phenotypic variance explained using summary statistics only. It allows for a range of models to be evaluated, including marginal genetic effects, GxE interaction effects and both effects jointly. Its implementation integrates all recent methodological developments and does not need external data to be uploaded by users.

Availability and implementation
The R package is available at https://gitlab.pasteur.fr/statistical-genetics/VarExp.git.

Supplementary information
Supplementary data are available at Bioinformatics online.
Whole-genome de novo sequencing reveals unique genes that contributed to the adaptive evolution of the Mikado pheasant
Authors: Lee Chien-Yueh , Hsieh Ping-Han , Chiang Li-Mei , Chattopadhyay Amrita , Li Kuan-Yi , Lee Yi-Fang , Lu Tzu-Pin , Lai Liang-Chuan , Lin En-Chung , Lee Hsinyu , Ding Shih-Torng , Tsai Mong-Hsun , Chen Chien-Yu , Chuang Eric Y. 
Published: May 2018

Abstract

Background
The Mikado pheasant (Syrmaticus mikado) is a nearly endangered species indigenous to high-altitude regions of Taiwan. This pheasant provides an opportunity to investigate evolutionary processes following geographic isolation. Currently, the genetic background and adaptive evolution of the Mikado pheasant remain unclear.

Results
We present the draft genome of the Mikado pheasant, which consists of 1.04 Gb of DNA and 15,972 annotated protein-coding genes. The Mikado pheasant displays expansion and positive selection of genes related to features that contribute to its adaptive evolution, such as energy metabolism, oxygen transport, hemoglobin binding, radiation response, immune response, and DNA repair. To investigate the molecular evolution of the major histocompatibility complex (MHC) across several avian species, 39 putative genes spanning 227 kb on a contiguous region were annotated and manually curated. The MHC loci of the pheasant revealed a high level of synteny, several rapidly evolving genes, and inverse regions compared to the same loci in the chicken. The complete mitochondrial genome was also sequenced, assembled, and compared against four long-tailed pheasants. The results from molecular clock analysis suggest that ancestors of the Mikado pheasant migrated from the north to Taiwan about 3.47 million years ago.

Conclusions
This study provides a valuable genomic resource for the Mikado pheasant, insights into its adaptation to high altitude, and the evolutionary history of the genus Syrmaticus, which could potentially be useful for future studies that investigate molecular evolution, genomics, ecology, and immunogenetics.
The LOINC RSNA radiology playbook - a unified terminology for radiology procedures
Authors: Vreeman Daniel J , Abhyankar Swapna , Wang Kenneth C , Carr Christopher , Collins Beverly , Rubin Daniel L , Langlotz Curtis P 
Published: May 2018

Abstract

Objective
This paper describes the unified LOINC/RSNA Radiology Playbook and the process by which it was produced.

Methods
The Regenstrief Institute and the Radiological Society of North America (RSNA) developed a unification plan consisting of six objectives 1) develop a unified model for radiology procedure names that represents the attributes with an extensible set of values, 2) transform existing LOINC procedure codes into the unified model representation, 3) create a mapping between all the attribute values used in the unified model as coded in LOINC (ie, LOINC Parts) and their equivalent concepts in RadLex, 4) create a mapping between the existing procedure codes in the RadLex Core Playbook and the corresponding codes in LOINC, 5) develop a single integrated governance process for managing the unified terminology, and 6) publicly distribute the terminology artifacts.

Results
We developed a unified model and instantiated it in a new LOINC release artifact that contains the LOINC codes and display name (ie LONG_COMMON_NAME) for each procedure, mappings between LOINC and the RSNA Playbook at the procedure code level, and connections between procedure terms and their attribute values that are expressed as LOINC Parts and RadLex IDs. We transformed all the existing LOINC content into the new model and publicly distributed it in standard releases. The organizations have also developed a joint governance process for ongoing maintenance of the terminology.

Conclusions
The LOINC/RSNA Radiology Playbook provides a universal terminology standard for radiology orders and results.
Antibiotic Stewardship in the Neonatal Intensive Care Unit: Effects of an Automatic 48-Hour Antibiotic Stop Order on Antibiotic Use
Authors: Astorga Maria Corazon , Piscitello Kyle J , Menda Nina , Ebert Ann M , Ebert Steven C , Porte Michael A , Kling Pamela J 
Published: May 2018

Abstract

Background
Meeting antibiotic stewardship goals in the neonatal intensive care unit (NICU) is challenging because of the unique nature of newborns and the lack of specificity of clinical signs of sepsis. Antibiotics are commonly continued for 48 hours pending culture results and clinical status. The goal of this study was to examine if the implementation of a 48-hour automatic stop (autostop) order during NICU admissions would decrease antibiotic use at UnityPoint Health–Meriter.

Methods
An observational double-cohort study was performed in a level 3 NICU. Antibiotic use was evaluated before and after the autostop initiative. The admission order set included 48 hours of ampicillin and gentamicin coverage.

Results
After the autostop initiation, total doses given per patient decreased by 35% and doses per patient-day decreased by 25% (P < .0001). The greatest effect was a 66% decrease in the use of vancomycin, an antibiotic not included in the admission order set. Providers proactively continued antibiotics for infants in whom they had high suspicion for sepsis and in those with positive blood or cerebral spinal fluid culture results.

Conclusions
An admission-order autostop was highly effective at decreasing antibiotic usage with no doses intended for a pathogen missed. Fewer doses of certain antibiotics outside of the admission order set were administered, particularly vancomycin, which results in our speculation that provider awareness of the antibiotic stewardship initiative might have altered prescribing practices.
Police Liaison Officers at Football: Challenging Orthodoxy through Communication and Engagement
Authors: Hoggett James , West Owen 
Published: May 2018

AbstractThis article expands upon research on the use of Police Liaison Teams (PLTs) within public order policing operations surrounding football fixtures. Using a Participant Action Research approach, the article reports on PLT use across multiple events and locations with different police forces, different personnel and fans and divergent command perspectives, as well as comparative data from PLT and non-PLT events. It identifies how accountability dynamics associated with the classification and management of risk in the policing of football may explain the continued reliance on more coercive policing tactics, as well as a number of other barriers that hinder the development of PLT use at football. Despite this, the article provides evidence that PLTs can offer similar benefits to the policing of football as they do to the policing of protest. In particular, we argue that developing such approaches will make the policing of football more human-rights complaint.
High Maternal Body Mass Index Is Associated with an Early-Onset of Overweight/Obesity in Pre-School-Aged Children in Malawi. A Multilevel Analysis of the 2015-16 Malawi Demographic and Health Survey
Authors: Ntenda Peter Austin Morton , Mhone Thomas Gabriel , Nkoka Owen 
Published: May 2018

AbstractBackgroundOverweight/obesity in young children is one of the most serious public health issues globally. We examined whether individual- and community-level maternal nutritional status is associated with an early onset of overweight/obesity in pre-school-aged children in Malawi.DesignData were obtained from the 2015-16 Malawi Demographic and Health Survey (MDHS). The maternal nutritional status as body mass index and childhood overweight/obesity status was assessed by using the World Health Organization (WHO) recommendations. To examine whether the maternal nutritional status is associated with overweight/obesity in pre-school-aged children, two-level multilevel logistic regression models were constructed on 4023 children of age less than five years dwelling in 850 different communities.ResultsThe multilevel regression analysis showed that children born to overweight/obese mothers had increased odds of being overweight/obese [adjusted odds ratio (aOR) = 3.11; 95% confidence interval (CI): 1.13–8.54]. At the community level, children born to mothers from the middle (aOR: 1.68; 95% CI: 1.02–2.78) and high (aOR: 1.69; 95% CI: 1.00–2.90) percentage of overweight/obese women had increased odds of being overweight/obese. In addition, there were significant variations in the odds of childhood overweight/obesity in the communities.ConclusionsStrategies aimed at reducing childhood overweight/obesity in Malawi should address not only women and their children but also their communities. Appropriate choices of nutrition, diet and physical activity patterns should be emphasized upon in overweight/obese women of childbearing age throughout pregnancy and beyond.