bluuebunny/crossref_metadata_2025_split huggingface dataset:
Poems
Authors: Ballesteros Bernardo 
Published: November 2024

AbstractThe chapter presents an overview of the key Mesopotamian (Sumero-Akkadian) and early Greek poems studied in the book. It offers plot summaries and details on dating, genre, and manuscript evidence and gives initial interpretative directions on the Greek poems. After a general discussion of dates and contexts (§1), it discusses Sumerian poems from the Old Babylonian period, dealing with gods, culture heroes, and the destruction of cities (§2); the Akkadian poems of Atra-ḫasīs, Gilgameš, Anzû, Enūma eliš and Erra and Išum (§3); and the Iliad, the Odyssey, key Homeric Hymns and Hesiod’s Theogony (§4). Relevant distinctions are outlined between different genres, such as narratives of divine praise and heroic narratives. On the Greek side, the chapter interprets the divine sub-plot of the Iliad and the role of the gods in the Odyssey. It also examines in which sense the Theogony and the Hymns are narrative poems.
Structuring the Narrative
Authors: Ballesteros Bernardo 
Published: November 2024

AbstractThe chapter starts the comparative investigation of poetic technique by charting the main scenes of divine assembly considered in the corpora and demonstrating that they fulfil a similar narrative function in Mesopotamian and early Greek narrative poetry. While the chapter maintains a discrete focus on individual traditions and poems, it observes the recurrence and diachronic elaboration of certain structural patterns. Inasmuch as the gods are the ultimate determinants in the mytho-poetic universe, these scenes give shape and structure to the poems by directing attention to plots’ inceptions, developments and resolutions, and by confronting the narrative’s key themes. Systems of divine assemblies afford a synoptic standpoint on each work’s design and narrative discourse. For instance, they set limits to Gilgameš, direct the Iliad’s plot through conflict and suffering, and justify the rise of Marduk and Zeus in Enūma eliš and Hesiod’s Theogony.
Comparing Conventions
Authors: Ballesteros Bernardo 
Published: November 2024

AbstractThis is the first of two chapters on poetic conventions which narrow the comparative focus. It discusses select motifs recurring in Babylonian and early Greek divine assemblies: divine reactions of unrest and fear (§1), sacrificial banqueting (§2), creation (§3), and wrathful withdrawal (§4). It considers how conventional techniques and structural motifs were passed down and elaborated. In both traditions, traditional phraseology and structures serve sophisticated poetic effects. Important thematic differences, to be further explored in Part II of the book, are also highlighted. The Babylonian chief gods, unlike Zeus, are often fearful and uncertain. At the divine banquet, Mesopotamian human actors are closer to the gods than their Greek counterparts. Creation narratives are more prominent in Babylonia, illustrating the sympathetic power of divine collective action and speech. In both traditions, by contrast, withdrawal story-patterns seem best assessed primarily as story-telling motifs rather than reflecting religious rituals securing the agricultural cycle.
Propertius’ Cynthia
Authors: Franklinos T E 
Published: November 2024

AbstractThis book considers the metapoetic and intra- and intertextual habits of Propertius and their relationship with the repetitious amatory discourse that he fashions for himself with his beloved, Cynthia. Where scholarship has tended to treat metaliterary and amatory aspects of Propertius’ poetry as distinct, this volume—focused on Books 3 and 4—argues that Propertius’ discussion of his own poetry and of his relationship to it as an author-figure—his metapoetic commentary—is closely married to, and can be clearly mapped onto, his account of his relationship with Cynthia, especially in Books 1–3. Moreover, it is shown that the elegist’s amorous discourse is constituted of a poetics of repetitiousness that is apt for the articulation of an elegiac relationship that, by its nature, cannot progress: Propertius’ encounters with Cynthia are repetitive, and he mirrors these in his recollection of lexical and thematic aspects of earlier poems in later ones. Each elegy provides a fragmentary glance at Propertius’ relationship and, through repetitions with variation, the poet (re)shapes his readers’ understanding of his amatory discourse. Furthermore, it is argued that, since his beloved is the embodiment of his poetry, Propertius’ account of the vicissitudes of their relationship allows him to articulate the varied transformations of his elegiac corpus; this becomes most significant as the closing cycle of Book 3 appears to end their relationship and to see the beginning of a radical experimentation with the generic bounds of elegy that is expanded in Book 4 and pre-empts aspects of Ovid’s poetic project.
The boundaries of Propertian elegy
Authors: Franklinos T E 
Published: November 2024

AbstractThis chapter treats the expanded—but continued—elegiac discourse of Book 4, and gives an overview of the ways in which Propertius’ intratextual engagement with his own verse and his interaction with the works of other poets (especially Vergil’s Aeneid) allow him further to explore the propria of elegy outside of the confines of the amatory (notably in 4.2, 4.6, 4.9, 4.10), but by no means to the complete exclusion of the latter. It is also shown that, by encouraging his readers to revisit his earlier books through the figures of Horos (4.1), Acanthis (4.5), Cynthia (4.7, 4.8), and Cornelia (4.11), Propertius recasts his prior presentation of his amatory discourse and destabilizes one’s interpretation of it.
Is autophagy always a death sentence? A case study of highly selective cytoplasmic degradation during phloemogenesis
Authors: Michalak Kornel M , Wojciechowska Natalia , Kułak Karolina , Minicka Julia , Jagodziński Andrzej M , Bagniewska-Zadworna Agnieszka 
Published: November 2024

AbstractBackground and AimsThe transformation of sieve elements from meristematic cells, equipped with a full complement of organelles, to specialized transport tubes devoid of a nucleus has long been enigmatic. We hypothesized a strong involvement of various degradation pathways, particularly macroautophagy in this context, emphasizing the importance of autophagic selectivity in the remaining viability of these cells.MethodsExperiments were performed on pioneer roots of Populus trichocarpa cultivated in rhizotrons under field conditions. Through anatomical, ultrastructural and molecular analyses, we delineate the stages of phloemogenesis and the concurrent alterations in the cytoplasmic composition of SEs.Key ResultsNotably, we observed not only macroautophagic structures, but also the formation of autophagic plastids, the selective degradation of specific organelles, vacuole disruption and the release of vacuolar contents. These events initially lead to localized reductions in cytoplasm density, but the organelle-rich cytoplasmic phase is safeguarded from extensive damage by a membrane system derived from the endoplasmic reticulum. The sieve element ultimately develops into a conduit containing electron-translucent cytoplasm. Eventually, the mature sieve element is a tube filled only by translucent cytoplasm, with sparse organelles tethered to the cell wall.ConclusionsAlthough the activation of programmed cell death pathways was postulated, the persistence of sieve elements indicates that protoplast depletion is meticulously regulated by hitherto unidentified mechanisms. This research elucidates the sequential processes occurring in these cells during phloemogenesis and unveils novel insights into the mechanisms of selective autophagy.
Ranking antibody binding epitopes and proteins across samples from whole proteome tiled linear peptides
Authors: McIlwain Sean J , Hoefges Anna , Erbe Amy K , Sondel Paul M , Ong Irene M 
Published: November 2024

Abstract

Introduction
Ultradense peptide binding arrays that can probe millions of linear peptides comprising the entire proteomes of human or mouse, or hundreds of thousands of microbes, are powerful tools for studying the antibody repertoire in serum samples to understand adaptive immune responses.

Motivation
There are few tools for exploring high-dimensional, significant and reproducible antibody targets for ultradense peptide binding arrays at the linear peptide, epitope (grouping of adjacent peptides), and protein level across multiple samples/subjects (i.e. epitope spread or immunogenic regions of proteins) for understanding the heterogeneity of immune responses.

Results
We developed Hierarchical antibody binding Epitopes and pROteins from liNear peptides (HERON), an R package, which can identify immunogenic epitopes, using meta-analyses and spatial clustering techniques to explore antibody targets at various resolution and confidence levels, that can be found consistently across a specified number of samples through the entire proteome to study antibody responses for diagnostics or treatment. Our approach estimates significance values at the linear peptide (probe), epitope, and protein level to identify top candidates for validation. We tested the performance of predictions on all three levels using correlation between technical replicates and comparison of epitope calls on two datasets, and results showed HERON’s competitiveness in estimating false discovery rates and finding general and sample-level regions of interest for antibody binding.

Availability and implementation
The HERON R package is available at Bioconductor https://bioconductor.org/packages/release/bioc/html/HERON.html.
Causal cardiovascular risk factors for dementia: insights from observational and genetic studies
Authors: Kjeldsen Emilie Westerlin , Frikke-Schmidt Ruth 
Published: November 2024

Abstract
The escalating prevalence of dementia worldwide necessitates preventive strategies to mitigate its extensive health, psychological, and social impacts. As the prevalence of dementia continues to rise, gaining insights into its risk factors and causes becomes paramount, given the absence of a definitive cure. Cardiovascular disease has emerged as a prominent player in the complex landscape of dementia. Preventing dyslipidaemia, unhealthy western-type diets, hypertension, diabetes, being overweight, physical inactivity, smoking, and high alcohol intake have the potential to diminish not only cardiovascular disease but also dementia. The purpose of this review is to present our current understanding of cardiovascular risk factors for Alzheimer’s disease and vascular dementia (VaD) by using clinical human data from observational, genetic studies and clinical trials, while elaborating on potential mechanisms. Hypertension and Type 2 diabetes surface as significant causal risk factors for both Alzheimer’s disease and VaD, as consistently illustrated in observational and Mendelian randomization studies. Anti-hypertensive drugs and physical activity have been shown to improve cognitive function in clinical trials. Important to note is that robust genome-wide association studies are lacking for VaD, and indeed more and prolonged clinical trials are needed to establish these findings and investigate other risk factors. Trials should strategically target individuals at the highest dementia risk, identified using risk charts incorporating genetic markers, biomarkers, and cardiovascular risk factors. Understanding causal risk factors for dementia will optimize preventive measures, and the implementation of well-known therapeutics can halt or alleviate dementia symptoms if started early. Needless to mention is that future health policies should prioritize primordial prevention from early childhood to prevent risk factors from even occurring in the first place. Together, understanding the role of cardiovascular risk factors in dementia, improving genome-wide association studies for VaD, and advancing clinical trials are crucial steps in addressing this significant public health challenge.
Sex-related differences in early morphological and clinical outcomes in patients with type A intramural haematoma: an observational cohort study
Authors: Xiao Yutong , Tian Chuan , Hu Kejian , Qian Xiangyang , Shu Chang 
Published: November 2024

Abstract

OBJECTIVES
To investigate sex-based differences in presenting characteristics and early outcomes of type A intramural haematoma.

METHODS
Patients with type A intramural haematoma in an institutional cohort were consecutively enrolled between December 2013 and July 2022. Presenting characteristics, morphological progression and all-cause death during hospitalization were evaluated according to patient sex.

RESULTS
Among 473 patients, 48.0% were female. Females were older (65.9 ± 9.1 vs 58.5 ± 11.5 years, P &lt; 0.001) with larger ascending aortic diameters (52.2 ± 6.6 vs 48.3 ± 6.1 mm, P &lt; 0.001), thicker haematomas (11.5 ± 4.9 vs 9.5 ± 3.4 mm, P &lt; 0.001) and more frequent focal intimal disruptions (45.4% vs 29.7%, P &lt; 0.001). Within 30 days of initial medical therapy, 89.8% of males vs 70.1% of females showed morphological regression or stable condition on repeat computed tomography angiography. The in-hospital mortality was 9.7% in females (n = 22) and 2.8% in males (n = 7). Kaplan–Meier analysis revealed higher early mortality in females (P = 0.002). Multivariable Cox regression showed female sex as an independent risk factor for early death (hazard ratio: 2.8, 95% confidence interval: 1.2–6.8, P = 0.021). Subgroup analysis revealed no heterogeneity according to subgroups including older age (71–90 years), ascending aortic diameter ≥50 mm, presence of focal intimal disruption, presence of pericardial effusion, haematoma thickness ≥11 mm and hypertension.

CONCLUSIONS
Female patients with type A intramural haematoma presented with worse characteristics, higher early morphological progression and an increased risk of early death compared to males.
Genomic insights into key mechanisms for carbon, nitrogen, and phosphate assimilation by the acidophilic, halotolerant genus Acidihalobacter members
Authors: Khaleque Himel Nahreen , Fathollahzadeh Homayoun , Kaksonen Anna H , Valdés Jorge , Vergara Eva , Holmes David S , Watkin Elizabeth L J 
Published: November 2024

Abstract
In-depth comparative genomic analysis was conducted to predict carbon, nitrogen, and phosphate assimilation pathways in the halotolerant, acidophilic genus Acidihalobacter. The study primarily aimed to understand how the metabolic capabilities of each species can determine their roles and effects on the microbial ecology of their unique saline and acidic environments, as well as in their potential application to saline water bioleaching systems. All four genomes encoded the genes for the complete tricarboxylic acid cycle, including 2-oxoglutarate dehydrogenase, a key enzyme absent in obligate chemolithotrophic acidophiles. Genes for a unique carboxysome shell protein, csoS1D, typically found in halotolerant bacteria but not in acidophiles, were identified. All genomes contained lactate and malate utilization genes, but only A. ferrooxydans DSM 14175T contained genes for the metabolism of propionate. Genes for phosphate assimilation were present, though organized differently across species. Only A. prosperus DSM 5130T and A. aeolianus DSM 14174T genomes contained nitrogen fixation genes, while A. ferrooxydans DSM 14175T and A. yilgarnensis DSM 105917T possessed genes for urease transporters and respiratory nitrate reductases, respectively. The findings suggest that all species can fix carbon dioxide but can also potentially utilize exogenous carbon sources and that the non-nitrogen-fixing species rely on alternative nitrogen assimilation mechanisms.
The Fourth Annual Symposium of the Midwest Aging Consortium
Authors: Kim Jinoh , Buffenstein Rochelle , Bronikowski Anne M , Pilar Vanegas Natalia-Del , Rosas Lorena , Agudelo-Garcia Paula , Mora Ana L , Rojas Mauricio , Englund Davis A , LeBrasseur Nathan K , Nunes Allancer , Robbins Paul D , Kohut Marian L , Kothadiya Siddhant , Bardhan Rizia , Camell Christina D , Sturmlechner Ines , Goronzy Jörg J , Yeh Chung-Yang , Lamming Dudley W , Huang Shijiao , Leiser Scott F , Escorcia Wilber , Gill Matthew S , Taylor Jackson R , Helfand Stephen L , Korm Sovannarith , Gribble Kristin E , Pehar Mariana , Blaszkiewicz Magdalena , Townsend Kristy L , McGregor Eric R , Anderson Rozalyn M , Stilgenbauer Lukas , Sadagurski Marianna , Taylor Alicia , McNeill Elizabeth , Stoeger Thomas , Bai Hua 
Published: November 2024

Abstract
The Midwest Aging Consortium (MAC) has emerged as a critical collaborative initiative aimed at advancing our understanding of aging and developing strategies to combat the rising prevalence of age-related diseases. Founded in 2019, MAC brings together researchers from various disciplines and institutions across the Midwestern United States to foster interdisciplinary geroscience research. This report summarizes the highlights of the Fourth Annual Symposium of MAC, which was held at Iowa State University in May 2023. The symposium featured presentations on a wide array of topics, including studies on slow-aging animals, cellular senescence and senotherapeutics, the role of the immune system in aging, metabolic changes in aging, neuronal health in aging, and biomarkers for measuring the aging process. Speakers shared findings from studies involving a variety of animals, ranging from commonly used species such as mice, rats, worms, yeast, and fruit flies, to less-common ones like naked mole-rats, painted turtles, and rotifers. MAC continues to emphasize the importance of supporting emerging researchers and fostering a collaborative environment, positioning itself as a leader in aging research. This symposium not only showcased the current state of aging biology research but also highlighted the consortium’s role in training the next generation of scientists dedicated to improving the healthspan and well-being of the aging population.
Radiolytic support for oxidative metabolism in an ancient subsurface brine system
Authors: Nisson Devan M , Kieft Thomas L , Castillo Julio , Perl Scott M , Onstott Tullis C 
Published: November 2024

Abstract
Long-isolated subsurface brine environments (Ma-Ga residence times) may be habitable if they sustainably provide substrates, e.g. through water-rock reactions, that support microbial catabolic energy yields exceeding maintenance costs. The relative inaccessibility and low biomass of such systems has led to limited understanding of microbial taxonomic distribution, metabolism, and survival under abiotic stress exposure in these extreme environments. In this study, taxonomic and metabolic annotations of 95 single-cell amplified genomes were obtained for one low biomass (103–104 cells/ml), hypersaline (246 g/L), and radiolytically enriched brine obtained from 3.1 km depth in South Africa’s Moab Khotsong mine. The majority of single-cell amplified genomes belonged to three halophilic families (Halomondaceae (58%), Microbacteriaceae (24%), and Idiomarinaceae (8%)) and did not overlap with any family-level identifications from service water or a less saline dolomite aquifer sampled in the same mine. Functional annotation revealed complete metabolic modules for aerobic heterotrophy (organic acids and xenobiotic oxidation), fermentation, denitrification, and thiosulfate oxidation, suggesting metabolic support in a microoxic environment. Single-cell amplified genomes also contained complete modules for degradation of complex organics, amino acid and nucleotide synthesis, and motility. This work highlights a long-isolated subsurface fluid system with microbial metabolism fueled by radiolytically generated substrates, including O2, and suggests subsurface brines with high radionuclide concentrations as putatively habitable and redox-sustainable environments over long (ka-Ga) timescales.
Novel logging while drilling azimuthal laterolog resistivity instrument design for oil-based mud
Authors: Kang Zhengming , Li Xin , Qin Haojie , Li Yongjie , Zhai Ying 
Published: November 2024

Abstract
This paper proposes a novel structure for the logging while drilling azimuthal laterolog resistivity instrument specifically designed for oil-based mud (OBM). The instrument utilizes capacitive coupling to quantitatively evaluate formation resistivity, permittivity, and the standoff between the measuring electrode and the wellbore wall. This innovation addresses the challenges associated with azimuthal resistivity measurement in highly inclined and horizontal wells, while also offering a deeper depth of investigation (DOI). The tool response characteristics and data inversion methodology were analyzed through numerical calculations. Initially, a 3D numerical simulation model of finite element method that incorporates the instrument structure was developed and its accuracy was verified. By adjusting the electrode size, its DOI was optimized to &gt;10 cm. The measurement impedance was examined in relation to varying measurement frequencies, the standoff, and the electrical parameters (resistivity, permittivity) of both the mud and the formation. Then, suitable instrument parameters and effects of formation and OBM were clarified. The simulation results show that the optimum frequency range is 0.1 to 100 MHz. To reduce the impact of standoff, the diameter of the drill collar should be larger than that of the conventional tool. Finally, a deep learning workflow was established, encompassing deep neural network training, parameter optimization, and testing. The accuracy and generalizability of the inversion method were validated using two complex synthetic stratigraphic models. The results of the inversed resistivity and standoff show good consistency with the set values of the two models. System numerical analysis demonstrates that the proposed instrument scheme can effectively address the drilling and formation evaluation requirements for ultra-deep wells and unconventional oil and gas resources, thereby providing a new option for data inversion.
Analytic Moments of TGARCH(1,1) Models with Polynomially Adjusted Densities
Authors: Carnero M Angeles , León Angel , Ñíguez Trino-Manuel 
Published: November 2024

Abstract
This article extends He, Silvennoinen, and Teräsvirta (2008, J Finan Econ, 6, 208–230) and Francq and Zakoïan (2010, GARCH Models) by providing analytical expressions for the moments of the unconditional distribution of the TGARCH(1,1) under alternative specifications for the conditional mean and different skewed distributions for the innovations. We consider polynomially adjusted (PA) densities, such as the PA Logistic, PA hyperbolic secant, and the PA Gaussian, along with the skewed Student-t. Our results show that (i) the main driver of the skewness of the TGARCH(1,1) is the skewness of the innovations, while the excess kurtosis has a comparatively lesser impact. However, both skewness and kurtosis of the innovations significantly affect the TGARCH(1,1) kurtosis; (ii) if the conditional mean is not constant, returns can be asymmetric even if innovations are symmetric; (iii) skewed innovations can generate cross-correlations different from zero, indicating leverage effect, even when the volatility model is symmetric. Finally, we illustrate our theoretical results with an empirical application to stock indices.