bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bronchial Asthma among Chechen Republic Schoolchildren: Regional Features
Authors: Ibisheva Aset Kh. , Shakhgireeva Madina R. , Uspanova Linda S. , Khildikharoeva Asya B. , Dzhabrailova Linda V.-M. , Efendieva Kamilla E. , Namazova-Baranova Leyla S. 
Published: November 2024

Background. The widespread increase in allergic diseases incidence is crucial issue of modern pediatrics. Objective. The aim of the study is to analyze the clinical and epidemiological features of bronchial asthma (BA) in schoolchildren of Chechen Republic.Methods. The study included two stages. 3398 children were surveyed via ISAAC questionnaire at the first stage. All participants were represented by 2 age groups: group 1 — 7–8 years old (n=1331), group 2 — 13–14 years old (n=2067). The second study phase covered clinical and diagnostic examination of children with asthma-like symptoms, enrolled by questionnaire (n=52) — 34 first-graders and 18 eighth-graders.Results. BA symptoms were recorded in 18.4% (625) of children (mostly in the older age group) according to the first stage results. Comparative analysis of the BA symptoms has revealed their prevalence in urban residents (p<0.05). BA was diagnosed in only 46.3% (37) of children during the clinical diagnostic stage. There were no statistically significant differences in age groups at the second stage of the study. No gender differences were revealed at both stages. The highest prevalence of verified BA was recorded in urban residents. Sensitization spectrum analysis in children with isolated BA in Chechen Republic has revealed predominance of domestic allergens sensitivity (house dust mites — D. pteronyssinus, D. farinae) and allergic rhinitis to pollen (ragwort, herd grass).Conclusion. Thus, our study results (according to the ISAAC program) have shown high prevalence of BA symptoms in schoolchildren of Chechen Republic at the first stage, however, the second stage indicated that allergy diagnosis cannot be based only on the questionnaire data and requires clinical and diagnostic verification. The identified regional features of the sensitization spectrum will allow physicians to perform economically optimal diagnosis of BA in children living in Chechen Republic.
The Prevalence of Sensitization to Food Allergens from the Group of “Big Eight” in Children with Atopic Phenotype: Cross-Sectional Study
Authors: Efendieva Kamilla E. , Levina Julia G. , Kalugina Vera G. , Vishneva Elena A. , Alekseeva Anna A. , Volkov Konstantin S. , Levin Pavel A. , Namazova-Baranova Leyla S. 
Published: November 2024

Background. Food allergy (FA) is a common chronic disease. There are no official data on the prevalence of FA in Russia. The results of only a few Russian studies of FA and anaphylaxis in children have been published.The aim of the study is to study the prevalence of sensitization to food allergens from the group of “big eight” in children with atopic phenotype living in the Moscow agglomeration.Methods. The cross-sectional study included children aged 0 to 17 years with complaints of seasonal manifestations of allergies / diagnosed with seasonal allergic rhinitis (pollinosis); with complaints of allergic reactions when eating any food; with complaints of atopic dermatitis. The determination of sensitization to allergens was carried out using ImmunoCAP technology, ImmunoCAP ISAC / ALEX2 allergy chips.Results. 240 children were included in the study. Sensitization to extracts of food allergens of the “big eight”, detected by the ImmunoCAP monoplex method, was determined in 1.5 (for fish) — 5 (for wheat) several times more often than with multiplex allergodiagnostics. In molecular allergodiagnosis, sensitization to hazelnut allergens was found in 57%, peanuts — in 47%, soy — in 39%, walnut — in 24%, chicken egg — in 18%, cow’s milk — in 12%, fish — in 9.7%, cashews — in 7.6%, shrimp — in 6.3%, wheat — in 4.6% of children. The frequency of food allergy symptoms, based on the assessment of the patients’ parents, was up to 7 times higher than the detected frequency of sensitization, accompanied by complaints of symptoms when eating the appropriate foods. Among the products causing symptoms in such patients, hazelnuts, cow’s milk, chicken egg and peanuts were in the lead.Conclusion. More than half of Russian children are sensitized to the allergens of the “big eight”, while clinically significant sensitization was noted 2 times less often. Sensitization to the allergen components of the PR-10 group of hazelnuts, peanuts and soybeans was most often detected. The frequency of FA diagnosed by a doctor is significantly lower than the frequency of the disease detected by the results of a survey of patients’ parents.
Occupational therapy practice in psychiatric day hospitals: A scoping review
Authors: Masango July , Casteleijn Daleen , Adams Fasloen , Rauch van der Merwe Tania 
Published: November 2024

Introduction: The aim of this scoping review was to explore the practice of occupational therapists in psychiatric day hospitals, globally.
Methodology: Searches were conducted in January 2024; 38 articles were screened and 22 were identified for data extraction. Articles were imported onto Covidence software. Data charting was done, and data was exported into a Microsoft Excel sheet, where content analysis was performed based on the review’s objectives. Synthesis of the results was done through discussion and reported according to the PRISMA for Scoping Reviews guidelines.
Results: Thirty-eight articles were included but only 22 were relevant. Group therapy, individualised therapy, vocational and community workshops were identified as common modes of intervention in psychiatric day hospitals. Occupation-based activities are integral to intervention. However, there was no explicit definition regarding the role of occupational therapy and practice guidelines for psychiatric day hospitals.
Conclusion: The general scope of occupational therapy remains the same as at overnight hospitals, day hospitals and community-based centres. It is mainly occupation-centred, function-orientated, and patient-centred. However, there remains ambiguity on specific practice principles and guidelines that clearly define the role of occupational therapists in day hospitals. There is a need for occupational therapy practice guidelines specific for psychiatric day hospitals.

Implications for Practice

The of study offers valuable insights into the current knowledge and availability and known about the role and scope of practice for occupational therapy in the rapidly expanding psychiatric day hospital setting, highlighting areas for further development.
The results of this study provide tangible evidence on therapeutic principles, practice approaches, programme content, and guide resource allocation for psychiatric day hospitals.
Ultimately, these results inform occupational therapy intervention protocols, solidify the profession’s role in psychiatric care, and contribute towards National Health Insurance (NHI) policy development.
Correlation of mean temperature and suicide rates of India
Authors: Poduri Gopala Sarma 
Published: November 2024

Environmental temperature affects life in numerous ways and spheres. There were reports that it impacts human behavior of suicide. Indian medical literature was almost silent on this topic. To find out the relationship between suicide and max., min., and average temperatures over a six-decade period in India. The suicides for the years from 1964 to the year 2021 were collected from the Ministry of Home, Govt. of India, displayed National Crimes Record Bureau-Accidental Death & Suicides in India (NCRB-ADSI) portal. The annual Max., Min., and Average temperature were obtained from the website Indiastat for the same period. After basic analysis, the Spearman rank correlation coefficient was performed to find the association between suicides and temperature. The statistics were done using online software from Social Science Statistics. There were 5157992 suicides in 59 years-1964-2021 with a highest of 164033 in 2021 and a lowest of 38217 in 1979. The maximum temperature recorded was 30.08 °C in 2009. The lowest temperature of 17.2 °C was recorded in 1971. The average temperature ranged from 23.74 °C to 26.21 °C. There were no outliers in either. Spearman rank correlation coefficient was estimated to be: 0.73509. Spearman rank correlation coefficient showed a p-value of &#60;0.001 for a significant large positive relationship between suicides and each of the three parameters studied. There was a substantial, monotonic, increasing positive relationship between the variables. Increasing temperature impacts suicide.
Spine-Abductor Syndrome: Novel Associations Between Lumbar Spine Disease and Hip Gluteal Muscle Pathology
Authors: Lavu Monish S. , Hecht Christian J. , Kaelber David C. , Grammatopoulos George , Homma Yasuhiro , Kamath Atul F. 
Published: November 2024

Background:
Risk factors for gluteal tears include age-related deterioration, female sex, and increased body mass index. As the literature that supports the sagittal relationship between the lumbar spine and the hip is increasing, there may be a parallel relationship between the perturbations in spinopelvic alignment caused by lumbar spine disease and gluteal muscle tears. Because no prior studies other than single-institution series have reported on this phenomenon, we investigated spine-abductor syndrome at the population level.

Methods:
This study utilized TriNetX, a federated research network that continuously aggregates deidentified electronic health record data from >92 million patients across the United States. The relative risks of gluteal tear encounter diagnoses and procedures were calculated for patients with and without the following characteristics: age ≥45 years, female sex, obesity, lumbar spine diagnoses, lumbar spine injections, and lumbar spine surgery. Utilizing the Cox proportional hazard model, we also analyzed gluteal tear-free survival over a period of ≥10 years in subgroups of patients who had been diagnosed with lumbar pathology, had been administered a lumbar injection, or had received lumbar surgery.

Results:
Of the 8,475,800 patients who had received lumbar spine diagnoses, undergone lumbar injections, and/or undergone lumbar surgeries, 458,311 patients (5.4%) had gluteal tears, representing a relative risk of 13.6 (95% confidence interval [CI]:13.6 to 13.6). After controlling for age, sex, and obesity, survival analysis showed markedly increased hazard ratios (HRs) for patients having a gluteal tear encounter diagnosis in the intervening 13 years (2010 to 2023) if they had had a previous lumbar spine pathology encounter diagnosis (HR: 4.8, 95% CI: 4.5 to 5.1), had undergone lumbar spine injections (HR: 7.7, 95% CI: 6.2 to 9.5), or had undergone lumbar spine surgery (HR: 6.6, 95% CI: 5.3 to 8.1) in 2010.

Conclusions:
These findings suggest a strong association between lumbar spine pathology and abductor tears. Further biomechanical and neuroanatomic studies may elucidate the effects of lumbar spine disease in relation to gluteal tears. Additionally, there may be a need to optimize diagnostic protocols for lateral hip pain in patients with a history of lumbar spine disease.

Level of Evidence:
Prognostic Level III. See Instructions for Authors for a complete description of levels of evidence.
Open-Door Cervical Laminoplasty Using Instrumentation of Every Level Versus Alternate Levels
Authors: Tamai Koji , Terai Hidetomi , Terakawa Masaki , Takahashi Shinji , Suzuki Akinobu , Nakamura Hiroaki 
Published: November 2024

Background:
In the setting of cervical open-door laminoplasty, the question of whether or not every opened laminar level should be instrumented has not been sufficiently investigated. We postulated that the surgical outcomes of open-door laminoplasty with instrumentation of every second opened level (skip-fixation) might not be inferior to those of laminoplasty with instrumentation of every opened level (all-fixation). The purpose of the present study was to test the noninferiority of laminoplasty with skip-fixation in improving myelopathy at 2 years postoperatively compared with all-fixation. Additionally, we compared radiographic and surgical outcomes between the 2 types of procedures.

Methods:
This prospective, multicenter, unblinded randomized controlled trial included patients ≥60 years of age who underwent C3 to C6 open-door cervical laminoplasty for the treatment of degenerative cervical myelopathy. Patients were allocated to the skip-fixation group (n = 80) or the all-fixation group (n = 75) using a permuted block method. The primary outcome was the between-group difference in the Japanese Orthopaedic Association (JOA) score at 2 years postoperatively. Secondary outcomes included surgical data, complications, 2-year change in the JOA score, Neck Disability Index (NDI), EQ-5D-5L (EuroQol 5-dimension 5-level instrument) score, visual analog scale (VAS) score for neck pain, and radiographic outcomes.

Results:
One hundred and thirty patients (including 66 in the skip-fixation group and 64 in the all-fixation group) completed the trial at 2 years (follow-up rate, 83.9%). The difference in the JOA score at 2 years was 0.0298 (95% confidence interval [CI], −0.706 to 0.766), which was within the noninferiority margin (p < 0.0001; noninferiority test). In the secondary analyses, laminoplasty with skip-fixation demonstrated a significantly shorter surgical time (p = 0.010; Mann-Whitney U test) and greater improvement in the VAS score for neck pain, NDI, and EQ-5D-5L score (p = 0.006, p = 0.047, p = 0.037, respectively; mixed-effect model) compared with all-fixation. There were no significant between-group differences in radiographic outcomes, including the hinge union rate.

Conclusions:
Skip-fixation may be sufficient to achieve noninferior 2-year postoperative improvement in myelopathy. Additionally, laminoplasty with skip-fixation potentially can lead to improvements in terms of neck pain, neck disability, and quality of life compared with all-fixation.

Level of Evidence:
Therapeutic Level II. See Instructions for Authors for a complete description of levels of evidence.
Advanced Care Planning for the Orthopaedic Patient
Authors: Segal Kathryn R. , Piana Lauren E. , Mujahid Nadia , Mikolasko Brian , Kuris Eren O. , Daniels Alan H. , Katarincic Julia A. 
Published: November 2024

➢ Advanced care planning most commonly refers to the act of planning and preparing for decisions with regard to end-of-life care and/or serious illness based on a patient’s personal values, life goals, and preferences.➢ Over time, advanced care planning and its formalization through advanced directives have demonstrated substantial benefits to patients, their families and caregivers, and the larger health-care system.➢ Despite these benefits, advanced care planning and advanced directives remain underutilized.➢ Orthopaedic surgeons interact with patients during sentinel events, such as fragility hip fractures, that indicate a decline in the overall health trajectory.➢ Orthopaedic surgeons must familiarize themselves with the concepts and medicolegal aspects of advanced care planning so that care can be optimized for patients during sentinel health events.
Association Between Nail Type and Aseptic Revision Risk After Cephalomedullary Nailing for Hip Fracture
Authors: Okike Kanu , Chang Richard N. , Royse Kathryn E. , Fasig Brian H. , Sadeghi Cameron , Jackman James M. , Navarro Ronald A. , Fang Andrew S. , Paxton Elizabeth W. 
Published: November 2024

Background:
Although the majority of intertrochanteric femoral fractures in the United States are now treated with cephalomedullary nailing, it remains uncertain whether differences in clinical performance by nail type exist. The purpose of this study was to compare the aseptic revision rates associated with the 3 most commonly utilized cephalomedullary nails in the United States today: the Gamma nail (Stryker), the INTERTAN (Smith+Nephew), and the Trochanteric Fixation Nail/Trochanteric Fixation Nail Advanced (TFN/TFNA; DePuy Synthes).

Methods:
Using an integrated health-care system’s hip fracture registry, patients ≥60 years of age who were treated with 1 of these 3 commonly used cephalomedullary nail devices were identified. Potential confounders were identified and controlled for, including age, gender, race or ethnicity, body mass index, smoking status, American Society of Anesthesiologists classification, anesthesia type, Elixhauser comorbidities, and the operating surgeon. Multivariable Cox proportional-hazards regression was used to evaluate the risk of aseptic revision (the primary outcome measure) by cephalomedullary nail type, with mortality and revisions unrelated to the index fracture considered as competing events.

Results:
There were 19,215 patients included in the study sample (71.4% female, 77.0% White), including 4,421 in the Gamma nail group, 2,350 in the INTERTAN nail group, and 12,444 in the TFN/TFNA nail group. In the multivariable analysis involving nails of all lengths, the INTERTAN group was found to have a higher risk of aseptic revision compared with the TFN/TFNA group (8-year crude revision rate, 2.9% compared with 1.8%; hazard ratio [HR], 1.62 [95% confidence interval (CI), 1.15 to 2.27]; p = 0.006). The increased risk associated with the INTERTAN nail was primarily seen among the long nails (HR, 1.83 [95% CI, 1.16 to 2.87]; p = 0.009) rather than the short nails (HR, 1.36 [95% CI, 0.87 to 2.11]; p = 0.18). There were no differences in aseptic revision observed between the Gamma group and the TFN/TFNA group.

Conclusions:
In this study of 19,215 patients with a hip fracture treated with cephalomedullary nailing, the INTERTAN nail was found to have a significantly higher risk of aseptic revision. Further research is required to determine whether these results could be related to the unique design of this implant.

Level of Evidence:
Therapeutic Level III. See Instructions for Authors for a complete description of levels of evidence.
Pemanfaatan kulit buah kakao pada proses alkalisasi biji kakao serta pengaruhnya terhadap mutu kakao bubuk
Authors: Cahyati Neni , Purwanto Eko Heri , Putri Selly Harnesa 
Published: November 2024

The problem facing the industry of cocoa powder in Indonesia is that cocoa powder on the market has a high fat content, high acidity, a color quality that is not comparable with imported cocoa products, and a variety of flavors and aromas. Alkalization is a method that can handle these problems. Alkalization is a process to improve the quality and appearance of cocoa powder. Alkalization is carried out by adding potassium, magnesium, and others to cocoa. High potassium content can be found in cocoa pod husks. Cocoa pod husks are the main by-product from the cocoa industry, constituting 67 – 76% of the cocoa fruit weight. Cocoa pod husk contains potassium, fiber, and antioxidants that function as biomaterials for food and non-food products. The aims of the study were to determine and evaluate the quality of cocoa powder with the effect of alkalization treatments using cocoa pod husks. The study was carried out at The Indonesian Industrial and Beverage Crops Research Institute, Sukabumi, West Java, from January to June 2022. This study was designed in a factorial completely randomized design. The first factor was the alkaline material, which consisted of two levels (cocoa pod husk and baking soda). The second factor was the concentration, which consisted of 3 levels (1%, 2%, and 3%). The variables observed were the L*, a*, b*, moisture content, ash content, fineness, pH, fat content, protein, antioxidant activity, and organoleptic properties. The results showed that the alkalization process with alkaline material from cocoa pod husk and a concentration of 2% is the best quality characteristic of cocoa powder in accordance with SNI 01-3747-2013.
Pobreza hídrica y estancamiento socioeconómico: el caso de Manresa
Authors: Llurdés Coit Joan Carles , Saurí Pujol David , Cerdan Heredia Rufí 
Published: November 2024

Este artículo aborda la problemática de la denominada “pobreza hídrica”, término que en los países desarrollados se utiliza para identificar a personas o hogares con dificultades para pagar el recibo del agua. La pobreza hídrica puede implicar cambios sustanciales en los usos y hábitos de uso de agua en los hogares con una tendencia extrema al ahorro de agua que puede repercutir en el confort y bienestar de los residentes. Además del ahorro extremo, la pobreza hídrica también estimula estrategias en forma de iniciativas para obtener subsidios y otras ayudas. A fin de investigar estas cuestiones y mediante entrevistas que combinan datos cuantitativos y cualitativos, el trabajo caracteriza los usos y hábitos de uso de agua, así como las estrategias para reducir el importe de los recibos en 40 hogares vulnerables del municipio de Manresa (Barcelona), un municipio en estancamiento socioeconómico. Entre las conclusiones más importantes del trabajo destacaríamos los enormes esfuerzos realizados para ahorrar agua sin que ello implique renunciar a hábitos de higiene y confort que se consideran imprescindibles como la ducha diaria por muy breve que sea ésta. Igualmente, la pobreza hídrica se suma a otras privaciones características de un sector de la ciudad degradado y en declive.
Critical Role of EEG Signals in Assessment of Sex-Specific Insights in Neurological Diagnostics via Machine Learning Approach
Authors: Bayazi Mohammad Javad Darvishi , Ghaemi Mohammad Sajjad , Rish Irina , Faubert Jocelyn 
Published: November 2024

Abstract

Early detection and diagnosis of pathology are essential for efficient treatment and therapeutic interventions. The emergence of Artificial Intelligence (AI) and deep machine learning techniques have demonstrated the promising capability of brain imaging data to predict various pathological diseases. However, plenty of diseases have imbalanced distribution across different sexes. Furthermore, the impact of sex-specific patterns and biomarkers in predicting diseases has remained unexplored as a fundamental subject matter to inform the treatment paradigms. This paper underscored the generalization and transferability of sex-related patterns in functional data, specifically Electroencephalogram (EEG) signals through Artificial Deep Neural Networks. We conducted training on a broad spectrum of EEG recordings involving participants ranging from 221 to 12,000, including healthy and pathological subjects. Our evaluation leveraged datasets from various sources and participant groups, featuring distribution shifts. While the artificial models demonstrated accurate sex detection on datasets without fine-tuning, their performance declined with significant distribution shifts. Furthermore, we explored the relationship between sex and pathology by visualizing salient features for target detection in distinct subgroups. Our findings revealed unprecedented insights into the negligible role of sex-specific patterns in pathology detection despite the presence of prominent and consistent patterns within sex groups. These results are essential for developing more robust and unbiased AI models for disease prediction and informing the treatment paradigms.
WITHDRAWN: Identifying diagnostic markers and constructing a prognostic model for pancreatic cancer based on microarray and bioinformatic analysis
Authors: Zhang Liqun , Liu Chang , Qian Dan , Tian Ye , Yang Ying , Li MengLu , You YiQin 
Published: November 2024

Abstract

The full text of this preprint has been withdrawn by the authors due to author disagreement with the posting of the preprint. Therefore, the authors do not wish this work to be cited as a reference. Questions should be directed to the corresponding author.