bluuebunny/crossref_metadata_2025_split huggingface dataset:
GRFS and CRFS in alternative donor hematopoietic cell transplantation for pediatric patients with acute leukemia
Authors: Mehta Rohtesh S. , Holtan Shernan G. , Wang Tao , Hemmer Michael T. , Spellman Stephen R. , Arora Mukta , Couriel Daniel R. , Alousi Amin M. , Pidala Joseph , Abdel-Azim Hisham , Ahmed Ibrahim , Aljurf Mahmoud , Askar Medhat , Auletta Jeffery J. , Bhatt Vijaya , Bredeson Christopher , Chhabra Saurabh , Gadalla Shahinaz , Gajewski James , Gale Robert Peter , Gergis Usama , Hematti Peiman , Hildebrandt Gerhard C. , Inamoto Yoshihiro , Kitko Carrie , Khandelwal Pooja , MacMillan Margaret L. , Majhail Navneet , Marks David I. , Mehta Parinda , Nishihori Taiga , Olsson Richard F. , Pawarode Attaphol , Diaz Miguel Angel , Prestidge Tim , Qayed Muna , Rangarajan Hemalatha , Ringden Olle , Saad Ayman , Savani Bipin N. , Seo Sachiko , Shah Ami , Shah Niketa , Schultz Kirk R. , Solh Melhem , Spitzer Thomas , Szer Jeffrey , Teshima Takanori , Verdonck Leo F. , Williams Kirsten M. , Wirk Baldeep , Wagner John , Yared Jean A. , Weisdorf Daniel J. 
Published: May 2019

Abstract
We report graft-versus-host disease (GVHD)-free relapse-free survival (GRFS) (a composite end point of survival without grade III-IV acute GVHD [aGVHD], systemic therapy–requiring chronic GVHD [cGVHD], or relapse) and cGVHD-free relapse-free survival (CRFS) among pediatric patients with acute leukemia (n = 1613) who underwent transplantation with 1 antigen–mismatched (7/8) bone marrow (BM; n = 172) or umbilical cord blood (UCB; n = 1441). Multivariate analysis was performed using Cox proportional hazards models. To account for multiple testing, P &lt; .01 for the donor/graft variable was considered statistically significant. Clinical characteristics were similar between UCB and 7/8 BM recipients, because most had acute lymphoblastic leukemia (62%), 64% received total body irradiation–based conditioning, and 60% received anti-thymocyte globulin or alemtuzumab. Methotrexate-based GVHD prophylaxis was more common with 7/8 BM (79%) than with UCB (15%), in which mycophenolate mofetil was commonly used. The univariate estimates of GRFS and CRFS were 22% (95% confidence interval [CI], 16-29) and 27% (95% CI, 20-34), respectively, with 7/8 BM and 33% (95% CI, 31-36) and 38% (95% CI, 35-40), respectively, with UCB (P &lt; .001). In multivariate analysis, 7/8 BM vs UCB had similar GRFS (hazard ratio [HR], 1.12; 95% CI, 0.87-1.45; P = .39), CRFS (HR, 1.06; 95% CI, 0.82-1.38; P = .66), overall survival (HR, 1.07; 95% CI, 0.80-1.44; P = .66), and relapse (HR, 1.44; 95% CI, 1.03-2.02; P = .03). However, the 7/8 BM group had a significantly higher risk for grade III-IV aGVHD (HR, 1.70; 95% CI, 1.16-2.48; P = .006) compared with the UCB group. UCB and 7/8 BM groups had similar outcomes, as measured by GRFS and CRFS. However, given the higher risk for grade III-IV aGVHD, UCB might be preferred for patients lacking matched donors.
Peptides identified on monocyte-derived dendritic cells: a marker for clinical immunogenicity to FVIII products
Authors: Jankowski Wojciech , Park Yara , McGill Joseph , Maraskovsky Eugene , Hofmann Marco , Diego Vincent P. , Luu Bernadette W. , Howard Tom E. , Kellerman Roberta , Key Nigel S. , Sauna Zuben E. 
Published: May 2019

Abstract
The immunogenicity of protein therapeutics is an important safety and efficacy concern during drug development and regulation. Strategies to identify individuals and subpopulations at risk for an undesirable immune response represent an important unmet need. The major histocompatibility complex (MHC)–associated peptide proteomics (MAPPs) assay directly identifies the presence of peptides derived from a specific protein therapeutic on a donor’s MHC class II (MHC-II) proteins. We applied this technique to address several questions related to the use of factor VIII (FVIII) replacement therapy in the treatment of hemophilia A (HA). Although &gt;12 FVIII therapeutics are marketed, most fall into 3 categories: (i) human plasma-derived FVIII (pdFVIII), (ii) full-length (FL)–recombinant FVIII (rFVIII; FL-rFVIII), and (iii) B-domain–deleted rFVIII. Here, we investigated whether there are differences between the FVIII peptides found on the MHC-II proteins of the same individual when incubated with these 3 classes. Based on several observational studies and a prospective, randomized, clinical trial showing that the originally approved rFVIII products may be more immunogenic than the pdFVIII products containing von Willebrand factor (VWF) in molar excess, it has been hypothesized that the pdFVIII molecules yield/present fewer peptides (ie, potential T-cell epitopes). We have experimentally tested this hypothesis and found that dendritic cells from HA patients and healthy donors present fewer FVIII peptides when administered pdFVIII vs FL-rFVIII, despite both containing the same molar VWF excess. Our results support the hypothesis that synthesis of pdFVIII under physiological conditions could result in reduced heterogeneity and/or subtle differences in structure/conformation which, in turn, may result in reduced FVIII proteolytic processing relative to FL-rFVIII.
The relationship of 1,25-dihydroxyvitamin D and Vitamin D binding protein in periodontitis
Authors: Rafique Sara , Hingorjo Mozaffer Rahim , Mumtaz Mahparah , Qureshi Masood Anwar 
Published: May 2019

Objective: This study was conducted to explore the relationship between 1,25-dihydroxy vitamin D (1,25(OH)2D) and Vitamin-D binding protein (DBP) in patients with periodontitis and healthy controls.
Methods: Seventy-five periodontitis cases were recruited from the dental OPD of Dow University of Health Sciences, Karachi. Diagnostic criteria of periodontitis were followed according to the probe pocket depth and clinical attachment loss. Seventy-five periodontal healthy controls were selected from the faculty and students of same university. Serum levels of 1,25(OH)2D and DBP were determined by ELISA.
Results: Significantly low levels of 1,25(OH)2D and high levels of serum DBP were observed in periodontitis patients compared to healthy controls (p<0.05), with levels of DBP increasing significantly with the severity of periodontitis (p=0.005). Concentrations of DBP correlated positively with 1,25(OH)2D, especially in cases with periodontitis (r =0.780; p<0.001).
Conclusion: Within the limits of the study, we conclude that low 1,25(OH)2D levels and high DBP levels are associated with periodontitis.
doi: https://doi.org/10.12669/pjms.35.3.482
How to cite this:Rafique S, Hingorjo MR, Mumtaz M, Qureshi MA. The relationship of 1,25-dihydroxyvitamin D and Vitamin D binding protein in periodontitis. Pak J Med Sci. 2019;35(3):847-851. doi: https://doi.org/10.12669/pjms.35.3.482
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
The learning environment of four undergraduate health professional schools: Lessons learned
Authors: Irfan Farhana , Al Faris Eiad , Al Maflehi Nasr , Karim Syed Irfan , Ponnamperuma Gominda , Saad Hussain , Ahmed Abdullah MA 
Published: May 2019

Background and Objectives: Learning is an interplay between cognition and environmental factors. Any learning environment, that fulfills the intrinsic and extrinsic needs of the students will probably lead to better and more promising learning outcomes. This study aimed to investigate the student perceptions of Learning Environment (LE) in four health schools of a large university and compare between schools, years of study, and gender.
Methods: Dundee Ready Education Environment Measure (DREEM) questionnaire and a socio-demographic questionnaire were completed by 1185 undergraduate students enrolled in the school of Medicine, Dentistry, Nursing and Applied Medical Sciences (AMS) of a large university during the academic year 2012-2013. Chi-square test was used to compare categorical variables. Independent student t-test or ANOVA (with Tukey post-hoc test) was used for continuous variables at a significance level of p ≤ 0.05.
Results: The mean total DREEM score was 89.23±33.3. The total DREEM mean scores for Dentistry (120.54±23.45) and Medicine (110.72±19.33) were higher compared with AMS (63.48±21.36) and Nursing (57.48±22.80) (p=0.000) (Post hoc Tukey p=0.000). First year students gave significantly higher positive perceptions ratings than the rest of the years (p=0.000). Total scores were significantly higher for male (92.78±33.86) than female students (84.70±32.25) p=0.000.
Conclusion: The LE significantly differed by year and gender. The students from non-integrated curricula (nursing and AMS) perceived the LE less positively than their integrated curriculum counterparts (medicine and dentistry). A qualitative study is needed to investigate the variation in the perception of LE among these groups.
doi: https://doi.org/10.12669/pjms.35.3.712
How to cite this:Irfan F, Al-Faris E, Al-Maflehi N, Karim SI, Ponnamperuma G, Saad H, et al. The learning environment of four undergraduate health professional schools: Lessons learned. Pak J Med Sci. 2019;35(3):598-604. doi: https://doi.org/10.12669/pjms.35.3.712
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Identification and phylogenetic analysis of oral Veillonella species isolated from the saliva of Japanese children
Authors: Djais Ariadna A. , Theodorea Citra Fragrantia , Mashima Izumi , Otomo Maiko , Saitoh Masato , Nakazawa Futoshi 
Published: May 2019

Background:As the most frequent infectious disease among children worldwide, dental caries have a strong relationship with oral hygiene status, specifically in the development of infection. OralVeillonellaspecies have a main role as early colonizers in the oral biofilm formation. Previously, oralVeillonellastrains were detected at the species level in the saliva of Thai children with different oral hygiene statuses. Here, we studied the oral hygiene status by examining the composition and proportion of oralVeillonellaspecies in saliva of Japanese children to compare with the previous results found in Thai children.Methods:Microbial samples collected from 15 Japanese children divided into three oral hygiene groups were cultured under anaerobic conditions after homogenization and dilution, and inoculated onto brain heart infusion and selective mediumVeillonellaagar. Genomic DNA was extracted from each isolate.Veillonellaspecies were detected by one-step PCR usingrpoBspecies-specific primers. To analyse the phylogenetic properties of the unknownVeillonellastrains, PCR amplification and sequence analysis ofrpoBwere conducted for 10 representative strains.Results:AlthoughV. rogosaewas found as the predominant species among all groups, its prevalence was significantly lower in the children with poor oral hygiene than in those with good oral hygiene.V. parvulawas the prevalent species in the poor oral hygiene group. Approximately 10% of the isolatedVeillonellastrains were not classified to any established species; the phylogenetic analysis showed that they were most closely related toV.infantiumConclusions:This study demonstrates that the composition and proportion of oralVeillonellaspecies in the saliva of Japanese children is correlated with different oral hygiene status. Changes in detection ratios ofV. parvulaandV. rogosaecan be useful indicators of oral hygiene status. Furthermore, new strains closely related toV.infantiumwere isolated from the saliva of Japanese children.
Sissy That Talk: A influência dos programas Rupaul Drag Race e Girls In The House no repertório linguístico de adolescentes e jovens adultos
Authors: Ferreira Ludmila Mendes , Salgado Ana Cláudia Peters , Gomes Michele Cristina Ramos 
Published: May 2019

O primeiro objetivo deste estudo piloto é descrever a influência dos repertórios linguísticos dos reality show estadunidense RuPaul Drag Race, e da websérie brasileira do youtube Girls In The House, no repertório linguístico dos adolescentes, jovens e adultos na comunidade LGBTTI. Para o desenvolvimento deste estudo, foram considerados os aspectos ideológicos e identitários (BAUMAN, 2005; MOITA LOPES, 2002) que permeiam as expressões linguísticas desses grupos. Além disso, ao refletir sobre o atual contexto de superdiversidade (VERTOVEC, 2007), de globalização (KUMARAVADIVELU, 2006) e de contatos linguísticos-culturais muito mais intensos (RYMES, 2010), notamos que o repertório linguístico que nasce dentro de grupos LGBTTIs (e que é disseminado pelos programas), também reconfigura-se em grupos de adolescentes e jovens adultos que se identificam com os aspectos culturais e ideológicos de grupos LGBTTI, sem necessariamente fazerem parte dessa comunidade. Um segundo objetivo deste estudo piloto é descrever e analisar o repertório de adolescentes e jovens adultos, por meio de dados retirados do Facebook, especificamente de postagens do grupo secreto LDRV: Melodrama Era que, atualmente, possui mais um milhão de membros. Posteriormente, foi realizado um estudo de caso a partir de entrevistas com membros do grupo a fim de descrever e analisar, os usos linguísticos adotados pelos indivíduos e relacioná-los ao repertório dos programas de televisão e da comunidade LGBTTIs. Os resultados apontam que as séries funcionam como modelo de uso linguístico para os falantes que, assim, expressam suas ideologias e questões identitárias.
Demographic Characteristic Of Burn Mortality And Its Relation To Tangential Excision At Burn Unit Of Cipto Mangunkusumo National General Hospital
Authors: Wardhana Aditya , Kurniasari Dhita 
Published: May 2019

Background: Burn injury is considered as major problem because of high mortality and morbidity. One of the several managements to decrease the mortality rate is wound excision. This study aimed to describe the characteristics of burn mortality in our burn unit and its association with timing of tangential excision.
Method: We collect data of burn patients who died in 2016 at Burn Unit of Cipto Mangunkusumo Hospital. We investigate the association of mortality and timing of tangential excision. The data were compared with other studies from online databases.
Result: Thirty-four burn patients died at RSCM Burn Unit from January - December 2016. 13 patients underwent early tangential excision, the rest had delayed or no tangential excision. Only length of stay (LOS) has statistically significant result. The early tangential excision group has significantly longer median LOS (p=0.003) compared to delayed tangential excision. From five relevant studies, three studies had higher mortality in early tangential excision group compared to delay group but fewer complications and shorter LOS. Two studies reported a significant reduction in mortality in early tangential excision group while culture positive wounds were more frequent in the delay group.
Conclusion: Mortality in our patients in early tangential excision group is fewer than the delayed one. The early tangential excision group has longer length of stay compared to delay tangential excision. Although there are pros and cons from the literature review, we suggest that early tangential excision should be done in burn patients.
İslâm ve Musiki
Authors: DİNÇ Sema 
Published: May 2019

İnsanlık tarihinin
başlangıcından bu yana hayatın daima içinde ve her anında olan mûsikî, İslâm’ın
yayılmasından bu yana her dönem icra ve var oluş yönüyle tartışmalara zemin
hazırlayan bir mesele olmuştur. Dinî ya da lâ dinî sahada var olan mûsikî,
günümüze değin birçok kez kitaplar yazılması ve hakkında çalışmalar yapılması
gerekli görülen mevzular arasında yerini almıştır. Fakat nice müellifler mûsikî
konusundaki dile getirilmesi gereken İslâmî ve fakat rasyonel fikirsel alanı, aynı
zamanda da fetva verme hususunu tam olarak doldurulamamış bir saha olarak
bırakmışlardır. Kaleme alınan eserler içerisinde mûsikîyi ilmî yöntemlerle
inceleyip çeşitli sonuçlara ulaşanlar olduğu gibi, tam aksine müziği aşırı bir şekilde
kötüleyenler de olmuştur. Bunun yanında henüz kütüphanelerde bulunan ve tetkik
edilmeyi bekleyen eserler de mevcuttur. Yapılan tüm bu tartışmalar ise ya tam
olarak konuyu açıklığa kavuşturamamış ya da duygusal yaklaşımlarla açıklanmaya
çalışılan bir hüviyete bürünmüştür. Bu durum da insanların zihinlerinde mûsikînin
dinî hükmünün halen netlik kazanmamasının, bir takım ayrılıkçı görüşlerin
devamının, dolayısıyla da şiddetli tartışmaların ve kendinden farklı düşünen
kişilere yöneltilen çeşitli ithamların müsebbibi olmuştur. Süleyman Uludağ’ın
müellifi olduğu İslâm ve Musiki adlı bu kitap, çağın gereklerini dikkate
alarak ve mûsikînin yeniden değerlendirilmesi gerekli görülerek hazırlanmış,
ilmî temellere oturtulmuş ve rasyonel bakış açısıyla tüm imkânlar kullanılarak
kaleme alınmıştır. Müellifin zikredilen eserinin konusu ise kendi ifadesiyle;
“sadece, mûsikînin dinî hükmü nedir ve ne olmalıdır?” sorularının
cevabıdır. Bu çalışma 1976 yılında ilk baskısı yayımlanan “İslâm Açısından
Musiki ve Semâ” adlı eserin de genişletilmiş halidir.
Numéro 42 - juin 2006
Authors: Ginsburgh Victor , Weber Shlomo 
Published: May 2019

Les enquêtes menées par la Commission européenne en 2001 montrent que la Flandre est bien plus multilingue que la Wallonie, ce qui est sans doute un fait bien connu, mais la différence est considérable. Alors que 59 % et 53 % des Flamands connaissent le français ou l’anglais respectivement, seulement 19 % et 17 % des Wallons connaissent le néerlandais ou l’anglais. Dans une Europe de plus en plus multilingue, 57 % des Wallons déclarent connaître le français uniquement. On dira que cela va mieux du côté des jeunes. A peine ! Si 12 % des Flamands de moins de 40 ans se déclarent unilingues, ce pourcentage s’élève à 51 % dans la même classe d’âge en Wallonie. Le syndrome d’H ‑ du nom de ce personnage qui a signé le contrat Francorchamps sans très bien le comprendre parce qu’il ne connaissait pas l’anglais ‑ est plus répandu que ce qu’on pouvait croire, et on est en droit de se demander s’il est compatible avec les déclarations de faire de la Wallonie une technopole. Comment exporte-t-on si on ne parle pas la langue des pays importateurs, ou tout au moins l’anglais qui devient, et ce pas nécessairement pour de bonnes raisons ou des raisons que l’on aime, la langue internationale. Mais il n’y a pas que l’anglais. Nous vivons, que nous le voulions ou non, dans un pays bilingue et nombreux sont ceux qui insistent sur la solidarité entre régions. Si le Sud veut vraiment que le Nord reste solidaire, la moindre chose est de connaître sa langue, même si c’est de façon imparfaite, même si le français est une langue plus internationale que le néerlandais et que la logique économique induit naturellement plus de Flamands à apprendre le français que des francophones à connaître le néerlandais.
Il faut reconnaître que ces questions ont été ouvertement posées dans le Plan Marshall. Les mesures que celui-ci préconise vont certes dans la bonne direction, mais sont sans doute très insuffisantes pour combler le retard dans un monde qui bouge très vite.
Numéro 91 - octobre 2011
Authors: Mayneris Florian 
Published: May 2019

Le gouvernement wallon cherche à stimuler l’innovation et la compétitivité des entreprises wallonnes grâce à la politique des pôles de compétitivité prévue par le Plan Marshall et son prolongement, le Plan Marshall2.Vert. Grâce à des subventions accordées pour des projets de R&D impliquant à la fois des entreprises et des laboratoires de recherche, les pouvoirs publics cherchent à stimuler la recherche collaborative et à favoriser de la sorte les échanges et fertilisations croisées entre les différents agents régionaux de l’innovation.
La Wallonie emboîte ainsi le pas à de nombreux autres pays et régions. Les politiques de clusters sont en effet présentées aujourd’hui comme l’instrument incontournable du développement local et de la compétitivité des états. Pourtant, leur analyse révèle une très grande diversité qui laisse parfois douter de leur cohérence. L’évaluation des Systèmes Productifs Locaux (SPL) et des Pôles de compétitivité français illustre bien cette hétérogénéité. Alors que les SPL ont soutenu des entreprises appartenant à des secteurs et des régions en relatif déclin, les pôles de compétitivité regroupent au contraire les champions industriels français. En termes d’impact, la politique des SPL ne semble pas avoir stimulé la productivité, l’emploi ou les exportations des entreprises aidées. S’il est trop tôt pour dire quoi que ce soit des pôles de compétitivité, des travaux sur les clusters de biotechnologie allemands montrent en revanche un impact positif des aides publiques sur l’innovation des entreprises soutenues.
Le corollaire de ceci est qu’il est difficile d’avoir un discours normatif sur les politiques de clusters. Les politiques de clusters ne sont pas bonnes ou mauvaises en soi. Il y a en revanche des initiatives qui marchent et d’autres pas. L’évaluation permet d’identifier les succès et les échecs, mais fournit aussi un éclairage sur le dispositif lui-même de la politique, utile à son évolution et à son amélioration.