bluuebunny/crossref_metadata_2025_split huggingface dataset:
INPP4B restrains cell proliferation and metastasis via regulation of the PI3K/AKT/SGK pathway
Authors: Chen Ying , Sun Zeyu , Qi Mei , Wang Xiao , Zhang Weifang , Chen Chunyan , Liu Juan , Zhao Weiming 
Published: March 2018

AbstractCervical cancer continues to be among the most frequent gynaecologic cancers worldwide. The phosphoinositide 3‐kinase (PI3K)/protein kinase B (AKT) pathway is constitutively activated in cervical cancer. Inositol polyphosphate 4‐phosphatase type II (INPP4B) is a phosphoinositide phosphatase and considered a negative regulatory factor of the PI3K/AKT pathway. INPP4B has diverse roles in various tumours, but its role in cervical cancer is largely unknown. In this study, we investigated the role of INPP4B in cervical cancer. Overexpression of INPP4B in HeLa, SiHa and C33a cells inhibited cell proliferation, metastasis and invasiveness in CCK‐8, colony formation, anchorage‐independent growth in soft agar and Transwell assay. INPP4B reduced the expression of some essential proteins in the PI3K/AKT/SGK3 pathway including p‐AKT, p‐SGK3, p‐mTOR, phospho‐p70S6K and PDK1. In addition, overexpression of INPP4B decreased xenograft tumour growth in nude mice. Loss of INPP4B protein expression was found in more than 60% of human cervical carcinoma samples. In conclusion, INPP4B impedes the proliferation and invasiveness of cervical cancer cells by inhibiting the activation of two downstream molecules of the PI3K pathway, AKT and SGK3. INPP4B acts as a tumour suppressor in cervical cancer cells.
Prognostic factors and patterns of recurrence in lymphovascular space invasion positive women with stage IIIC endometriod endometrial cancer
Authors: Cuylan Zeliha F. , Oz Murat , Ozkan Nazli T. , Comert Gunsu K. , Sahin Hanifi , Turan Taner , Akbayir Ozgur , Kuscu Esra , Celik Husnu , Dede Murat , Gungor Tayfun , Meydanli Mehmet M. , Ayhan Ali 
Published: March 2018

AbstractAimThe purpose of this study was to determine the prognostic factors and patterns of failure in lymphovascular space invasion (LVSI)‐positive women with stage IIIC endometrioid endometrial cancer (EC).MethodsA multicenter, retrospective, department database review was performed to identify LVSI‐positive patients with stage IIIC endometrioid EC at five gynecological oncology centers in Turkey. Demographic, clinicopathological and survival data were collected.ResultsWe identified 172 LVSI‐positive women with stage IIIC endometrioid EC during the study period; 75 (43.6%) were classified as Stage IIIC1 and 97 (56.4%) as Stage IIIC2. The median age at diagnosis was 59 years, and the median duration of follow up was 34.5 months. The total number of recurrences was 46 (26.7%). We observed 14 (8.1%) locoregional recurrences, 12 (7.0%) retroperitoneal failures and 20 (11.6%) distant relapses. For the entire study cohort, 5‐year progression‐free survival (PFS) was 67.4%, while the 5‐year overall survival (OS) rate was 75.1%. Grade 3 histology (hazard ratio [HR] 2.62, 95% confidence interval [CI] 1.34–5.12; P = 0.005), cervical stromal invasion (HR 2.33, 95% CI 1.09–4.99; P = 0.028) and myometrial invasion (MMI) ≥50% (HR 4.0, 95% CI 1.16–13.69; P = 0.028) were found to be independent prognostic factors for decreased OS.ConclusionUterine factors such as grade 3 disease, cervical stromal invasion and deep MMI seem to be independently associated with decreased OS in LVSI‐positive women with stage IIIC endometrioid EC. The high distant recurrence rate in this subgroup of patients warrants further studies in order to identify the most effective treatment strategy for those patients.
Labor induction versus expectant management at early term in pregnancies with second trimester elevated human chorionic gonadotropin or alpha fetoprotein
Authors: Yefet Enav , Kuzmin Olga , Schwartz Naama , Basson Flora , Nachum Zohar 
Published: March 2018

AbstractAimElevated human chorionic gonadotropin (HCG) and alpha fetoprotein (AFP) have been linked to placental dysfunction and associated morbidities. We aimed to compare the induction of labor with expectant management at term in those pregnancies for the prevention of neonatal and maternal morbidities.MethodsWomen with second trimester HCG ≥ 2 and/or AFP ≥ 2 multiples of the median, without additional maternal or fetal complications, from their 38th gestational week were offered the choice of labor induction or expectant management. The primary outcomes were maternal composite outcome (composed of cesarean deliveries, pre‐eclampsia or placental abruption) and neonatal composite outcome (composed of antenatal or neonatal death, Apgar score at 5 min < 7, admission to the neonatal intensive care unit, need for phototherapy, respiratory abnormalities, birth trauma or neonatal infection).ResultsOf 305 women, 124 women chose to undergo labor induction, and 181 women chose expectant management. The composite maternal outcome in the expectant management group was twice the rate of the labor induction group, although it did not reach statistical significance (18 [10%] vs 6 [5%]; P = 0.1; relative risk [expectant/induced] 2.04; 95% confidence interval 0.8–5.0).Increased rate of phototherapy led to increased neonatal composite outcomes in the labor induction group compared with the expectant management group (34 [27%] vs 27 [15%], respectively = 0.007).ConclusionIn pregnancies with elevated AFP and/or HCG, early term labor induction initiated a trend towards improvement in maternal outcome but increased the rate of mild neonatal morbidity. The statistical insignificance of the large effect on the maternal outcome might reflect the lack of statistical power. Further research is needed to address this limitation.
Solitary fibrous tumor of the ovary
Authors: Meena Monika , Jindal Tarun , Duggal Rajan , Gupta Atul 
Published: March 2018

AbstractSolitary fibrous tumors commonly occur in the pleura and are rare elsewhere, especially in the female genital system. We present a case of a solitary fibrous tumor arising from the ovary in a young female in the reproductive age group. The tumor could be excised laparoscopically. We also describe the histopathological and immunohistochemical features that can help establish its diagnosis.
Magnetic resonance imaging of degeneration of uterine adenomyosis during pregnancy and post‐partum period
Authors: Hirashima Hiroto , Ohkuchi Akihide , Usui Rie , Kijima Shigeyoshi , Matsubara Shigeki 
Published: March 2018

AbstractDegeneration of adenomyosis during pregnancy and the post‐partum period is very rare. A 42‐year‐old Japanese parous woman with four normal‐term deliveries, who presented with abdominal pain and fever at 22 weeks of gestation with transient increases of the white blood cell count and C‐reactive protein, demonstrated sustained inflammation after cesarean section at 29 weeks of gestation due to the occurrence of gestational hypertension with late deceleration. The noncontrast‐enhanced magnetic resonance imaging (MRI) at 22 weeks demonstrated a poorly demarcated hypointense area at the posterior uterine wall on T1‐ and T2‐weighted imaging. The 2nd MRI 2 weeks after the cesarean section showed hypointensity on a T1‐weighted image and hyperintensity on a T2‐weighted image, allowing confirmation of the diagnosis of degeneration of adenomyosis. Repeated MRIs were clinically useful to diagnose the degeneration of adenomyosis.
Utility of fetal anteroposterior to transverse cerebellar diameter ratio to exclude cerebellar hypoplasia in trisomy 18
Authors: Takano Mayumi , Nakata Masahiko , Oji Ayako , Nagasaki Sumito , Umemura Nahomi , Maemura Toshimitsu , Morita Mineto 
Published: March 2018

AbstractAimThis study was aimed to determine reference ranges for fetal cerebellar hemisphere biometry, including the transverse cerebellar diameter (TCD), anteroposterior cerebellar diameter (APCD) and APCD/TCD ratio in normal fetuses. In addition, we investigated which parameter would be useful for cerebellar hypoplasia in trisomy 18.MethodsThis retrospective study included 340 normal singleton pregnancies and 15 cases of trisomy 18, in all of which fetal cerebellar biometry was performed between 14 and 40 weeks of gestational age (GA). The TCD, APCD and APCD/TCD ratio were assessed ultrasonographically.ResultsIn normal fetuses, the TCD (rs = 0.876, P < 0.001) and APCD (rs = 0.791, P < 0.001) were strongly correlated with GA. However, the APCD/TCD ratio was not correlated with GA (rs = 0.058, P = 0.289), with median values of 0.52. Low TCD, APCD and APCD/TCD ratio values were detected in 53%, 100% and 100% of trisomy 18 cases, respectively. The median APCD/TCD ratio for trisomy 18 was 0.39 (range, 0.30–0.43), which was significantly lower than that of normal fetuses (P < 0.001). A cut‐off APCD/TCD ratio of 0.44 served as a good predictor for trisomy 18 (sensitivity 100%, specificity 95.3% and negative predictive value 100%).ConclusionThis study shows that TCD and APCD are correlated with GA, while the APCD/TCD ratio is a fixed value throughout gestation. Using the APCD/TCD ratio to assess cerebellar hypoplasia in trisomy 18 is useful because it does not require the individual evaluation of the TCD and APCD.
Economic valuation of a rise in ambient radiation risks: Hedonic pricing evidence from the accident in Fukushima
Authors: Munro Alistair 
Published: March 2018

AbstractUsing a combined data set of radiation levels and property prices from Fukushima and Miyagi prefectures that runs from 2009 to early 2017, the economic impact of radiation from the Fukushima nuclear accident is assessed. A 1 percent rise in radiation is associated with approximately 0.051 percentage drop in housing prices and though the level of radiation falls substantially after 2011, the estimated elasticity is broadly stable. The associated estimate of VSL (value of a statistical life) is in the region of US$4.5–6.4 million, which suggests no strong element of dread or overestimation of risks is present.
Population pharmacokinetics of ceftazidime after a single intramuscular injection in wild turtles
Authors: Cerreta A. J. , Lewbart G. A. , Dise D. R. , Papich M. G. 
Published: March 2018

Ceftazidime, a third‐generation cephalosporin, is important for treating opportunistic bacterial infections in turtles. Antibacterial dosage regimens are not well established for wild turtles and are often extrapolated from other reptiles or mammals. This investigation used a population pharmacokinetic approach to study ceftazidime in wild turtles presented for rehabilitation. Ceftazidime was administered to 24 wild turtles presented to the Turtle Rescue Team at North Carolina State University. A sparse blood sampling protocol was used to collect samples from 0 to 120 hr with three samples per individual after injection. Plasma samples were analyzed by high‐pressure liquid chromatography (HPLC). A nonlinear mixed‐effects model (NLME) was fitted to the data to determine typical values for population parameters. We identified a long half‐life (T½) of approximately 35 hr and volume of distribution (VSS) of 0.26 L/kg. We concluded that this long T½ will allow for a dose of 20 mg/kg injected IM to maintain concentrations above the MIC of most wild‐type bacteria for 5 days. Because of long intervals between injections, stability of stored formulations was measured and showed that 90% strength was maintained for 120 hr when stored in the refrigerator and for 25 days when stored in the freezer.
Applying a hydrogeomorphic channel classification to understand spatial patterns in riparian vegetation
Authors: Shaw Jeremy R. , Cooper David J. , Sutfin Nicholas A. 
Published: March 2018

AbstractQuestionsHydrogeomorphic channel classifications are widely employed to understand natural phenomena in Earth sciences, but are rarely used in riparian vegetation studies. However, when these types of classifications correspond to physical process domains (discrete landscape units with consistent abiotic attributes), they may be useful in distinguishing habitat and vegetation types. We assessed the ecological significance of a hydrogeomorphic stream channel classification by addressing the following questions: (1) does perennial plant community composition differ among hydrogeomorphic channel types; (2) which species and functional groups contribute to compositional variation among channel types in the Sonoran Desert; and (3) what are the stream reach‐scale geomorphic drivers of compositional variation?LocationSonoran Desert, Arizona, USA.MethodsWe compared perennial riparian plant community composition among five a priori hydrogeomorphic channel types at 86 stream reaches in arid ephemeral watersheds. Floristic differences among channel types were assessed using PERMANOVA. GLM were used to identify species and functional groups whose abundance differed among channel types. Abiotic drivers of compositional differences were identified through correlations among biotic and abiotic matrices.ResultsCommunity composition differed significantly among channel types, with distinctive vegetation in bedrock, piedmont headwater and braided channels. While different from other channel types, vegetation in bedrock with alluvium and incised alluvium channels was broadly similar, but could be distinguished by the abundance of common species and functional groups. The density of drought‐deciduous subshrubs, as well as large woody plants with evergreen, drought‐deciduous and photosynthetic stem phenology contributed to the observed compositional variance. Bed slope was the primary driver of compositional differences among channel types, with elevation providing additional explanatory power.ConclusionsHydrogeomorphic channel classifications corresponding to distinctive fluvial process domains are useful for understanding spatial variability in riparian habitats and resulting differences in plant community composition in the Sonoran Desert. Analogous spatial patterns of riparian plant communities previously reported from other arid regions suggest that these general channel types are broadly applicable.
The apparent non‐host resistance of Ethiopian mustard to a radish‐infecting strain of Turnip mosaic virus is largely determined by the C‐terminal region of the P3 viral protein
Authors: Sardaru Papaiah , Sinausía Laura , López‐González Silvia , Zindovic Jelena , Sánchez Flora , Ponz Fernando 
Published: March 2018

SummaryTwo different isolates of Turnip mosaic virus (TuMV: UK 1 and JPN 1) belonging to different virus strains were tested on three different Brassica species, namely turnip (Brassica rapa L.), Indian mustard (Brassica juncea L.) and Ethiopian mustard (Brassica carinata A. Braun). Although all three hosts were readily infected by isolate UK 1, isolate JPN 1 was able to establish a visible systemic infection only in the first two. Ethiopian mustard plants showed no local or systemic symptoms, and no virus antigens could be detected by enzyme‐linked immunosorbent assay (ELISA). Thus, this species looks like a non‐host for JPN 1, an apparent situation of non‐host resistance (NHR). Through an experimental approach involving chimeric viruses made by gene interchange between two infectious clones of both virus isolates, the genomic region encoding the C‐terminal domain of viral protein P3 was found to bear the resistance determinant, excluding any involvement of the viral fusion proteins P3N‐PIPO and P3N‐ALT in the resistance. A further determinant refinement identified two adjacent positions (1099 and 1100 of the viral polyprotein) as the main determinants of resistance. Green fluorescent protein (GFP)‐tagged viruses showed that the resistance of Ethiopian mustard to isolate JPN 1 is only apparent, as virus‐induced fluorescence could be found in discrete areas of both inoculated and non‐inoculated leaves. In comparison with other plant–virus combinations of extreme resistance, we propose that Ethiopian mustard shows an apparent NHR to TuMV JPN 1, but not complete immunity or extreme resistance.
Formulation, stability study and preclinical evaluation of a vaginal cream containing curcumin in a rat model of vulvovaginal candidiasis
Authors: Fernandes Lígia de Souza , Amorim Yuri Martins , da Silva Elton Libério , Silva Samuel Calixto , Santos Alécia Junia Aparecida , Peixoto Franciele Natália , Neves Pires Luara Moniele , Sakamoto Raquel Yumi , Horta Pinto Flávia do Carmo , Scarpa Maria Virgínia Costa , Araújo Marcelo Gonzaga de Freitas 
Published: March 2018

SummaryOwing to the growing resistance among isolates of Candida species to usual antifungal agents and the well‐known therapeutic potential of curcumin, the purpose of this study was to develop and validate a vaginal formulation containing this substance and to evaluating its effectiveness in the treatment of experimental vulvovaginal candidiasis. Curcumin was incorporated in a vaginal cream in three concentrations (0.01%, 0.1% and 1.0%). The different concentrations of the cream and its controls were intravaginally administered in an immunosuppressed rat model to evaluate the efficacy in the treatment of experimental vulvovaginal candidiasis. Samples of the cream were also subjected to centrifugation and physical stability tests and an analytical method for quantification of curcumin was validated based on HPLC. The formulation was stable and the HPLC method could be considered suitable for the quantitative determination of curcumin in the cream. After 6 days of preclinical study, the number of infected animals was 1/6 in all groups treated with curcumin vaginal cream and the fungal burden showed a progressive reduction. Reduction in the inflammatory infiltrate was observed in the group treated with 1.0% cream. Vaginal cream containing curcumin could be considered a promising effective antifungal medicine in the treatment of vulvovaginal candidiasis.
Morton Deutsch: Celebrating His Theorizing and Research
Authors: Johnson David W. , Johnson Roger T. , Tjosvold Dean , Roseth Cary J. 
Published: March 2018

AbstractThis tribute to Morton Deutsch celebrates his unique contributions to social psychological theory, research, cross‐cultural applications to business and organizational settings, and cross‐species applications. Mort's theorizing progressed from cooperation and competition to trust to conflict resolution to distributive justice, and finally to oppression. As a researcher, Mort was remarkably creative and innovative. His ability to think of ways to study experimentally complex social phenomena created a revolution in social psychology research. Mort's theories and research is being used to understand the nature of effective leadership and organization functioning in business and industry in Asia and other parts of the world. The strong cross‐cultural validation of Mort's theorizing and research is unusual in the social sciences. Finally, Mort's cooperation and competition theory operationalizes the dynamics between cooperative and competitive processes in a variety of species and accounts for the mechanisms (e.g., goal structures) that underlie different evolutionary processes.
Pressure exposure and catheter impingement affect the recorded pressure in the Manoscan 360™ system
Authors: Babaei A. , Szabo A. , Yorio S. D. , Massey B. T. 
Published: March 2018

AbstractBackgroundThe accuracy of pressure measurements by Manoscan high‐resolution manometry (HRM) system is affected by pressure drift (PD). The PD is partly related to temperature and study duration, but other factors that contribute to errant pressure recording have not been systematically evaluated. The aim of this study was to investigate and quantify contributing factors to pressure recording error.MethodsIn total, 660 in vitro experiments were conducted on seven HRM catheters to determine the effects of sustained pressure exposure, catheter impingement, temperature, duration of study, and immersion in saline or acid on recorded pressure and PD.Key ResultsAt room temperature and without application of pressure, the PD was negligible. Application of sustained pressure significantly increased PD and catheter impingement of even 15° produced remarkable increases in the recorded pressure as well as post‐recording PD. There was significant variability across sensors in their propensity to develop PD with temperature. Body (37°C) and freezing (0°C) temperatures resulted in significantly higher absolute value of PD in the opposite algebraic direction, respectively (for individual sensors). Although the overall trend was for higher PD with increasing temperature, some of the pressure sensors demonstrated inherently negative PD at body temperature.Conclusions and InferencesIn addition to the known effects of temperature, both sustained pressure exposure and catheter impingement significantly affect the recorded pressure and the magnitude of the PD observed at the end of the recording. These effects can be substantial enough to result in erroneous manometric diagnoses.
HLA‐DRB1*09:01 allele is associated with anti‐E immunization in a Chinese population
Authors: Tian Li , Hou Li , Wang Lixin , Xu Hong , Xiao Jie , Ying Binwu 
Published: March 2018

BACKGROUNDAnti‐E is the most common and important RBC alloantibody in the Chinese population. Several studies have demonstrated that the production of specific RBC alloantibodies is associated with HLA‐DRB1 polymorphisms. Considering that the Chinese population has its own unique characteristics of HLA‐DRB1 polymorphisms, we investigate whether specific HLA‐DRB1 alleles are associated with E immunization in a Chinese population.STUDY DESIGN AND METHODSThe frequencies of HLA‐DRB1 phenotypes were compared among 78 patients possessing anti‐E and 192 healthy blood donors. HLA‐DRB1 genotyping was carried out using sequence‐based typing method. The TEPITOPEpan software was used to predict E antigen–derived anchor peptides binding to HLA‐DRB1 molecules.RESULTSThe frequency of HLA‐DRB1*09:01 phenotype was significantly higher in the patients with anti‐E than in healthy controls: 76.9% versus 27.6% (odds ratio, 8.7; 95% confidence interval, 4.7‐16.2; corrected p value < 0.0034). One E antigen–derived anchor peptide (217WMFWPSVNS225) was predicted to bind three HLA‐DRB1 molecules (HLA‐DRB1*04:05, *04:17, and *13:02); however, no anchor peptide was predicted to bind HLA‐DRB1*09:01.CONCLUSIONThis study indicated that HLA‐DRB1*09:01 phenotype was significantly more prevalent in E‐immunized patients than the control group. It suggested that HLA‐DRB1*09:01 molecule might represent a susceptibility phenotype enhancing formation of anti‐E alloantibody. Further study would be necessary to identify the anchor peptide responsible for E alloimmunization by stimulation of specific T cells by peptide originating from E antigen.