bluuebunny/crossref_metadata_2025_split huggingface dataset:
Applied Anatomy of Pelvic Lymph Nodes and Its Clinical Significance for Prostate Cancer:A Single-Center Cadaveric Study
Authors: Jia-Jun Chen , Zai-Sheng Zhu , Yi-Yi Zhu , Hong-Qi Shi 
Published: August 2019

Abstract
Background Pelvic lymph node dissection (PLND) is one of the most important steps in radical prostatectomy (RP). Not only can PLND provide accurate clinical staging to guide treatment after prostatectomy but PLND can also improve the prognosis of patients by eradicating micro-metastases. However, reports of the number of pelvic lymph nodes have generally come from incomplete dissection during surgery, there is no anatomic study that assesses the number and variability of lymph nodes. Our objective is to assess the utility of adopting the lymph node count as a metric of surgical quality for the extent of lymph node dissection during RP for prostate cancer by conducting a dissection study of pelvic lymph nodes in adult male cadavers.
Methods All 30 adult male cadavers underwent pelvic lymph node dissection (PLND), and the lymph nodes in each of the 9 dissection zones were enumerated and analyzed.
Results A total of 1267 lymph nodes were obtained. The number of lymph nodes obtained by local PLND was 4-22 (14.1±4.5), the number obtained by standard PLND was 16-35 (25.9±5.6), the number obtained by extended PLND was 17-44 (30.0±7.0), and the number obtained by super-extended PLDN was 24-60 (42.2±9.7).
Conclusions There are substantial inter-individual differences in the number of lymph nodes in the pelvic cavity. These results have demonstrated the rationality and feasibility of adopting lymph node count as a surrogate for evaluating the utility of PLND in radical prostatectomy, but these results need to be further explored.
Difficulties of social networks building in international medical students: a qualitative study
Authors: Li Yuping , Lu Guangyu , Wang Zhengbing , Liang Jingyan , Yan Bingchun , Lu Wei , Yang Lin , Wang Xiaohong , Chen Qi 
Published: August 2019

Abstract
Background: The number of international medical students studying in China has largely increased over the past decades. However, few studies have addressed the difficulties that the international medical students face and there is a dearth of information on understanding the difficulties these students confront during their social integration in host countries. Therefore, the aim of this study was to investigate the international medical students’ difficulties to build social networks during their studying overseas.
Methods: This study was designed primarily with the aim of enhancing understanding of the International Bachelor of Medicine and Bachelor of Surgery (MBBS) students’ difficulties in social networks building. 26 MBBS students from year-3 and year-4 were asked by the question: what are the difficulties to establish the social networks you face? Thematic analysis was conducted by MAXQDA.
Results: The result of the individual interviews revealed that language barriers, (lack of) communication skills, personality factors, intercultural differences and study pressure were key factors that hindered the MBBS students’ adaptation to the Chinese culture and social networks building in China.
Conclusions: This study reveals several potential coping strategies which could promote the social inclusion and cultural integration of the MBBS students, including providing interactive language training programs, organizing diverse programs enhancing intercultural communication, maintaining strong support networks and endeavoring the MBBS students to actively engage themselves in their learning and living environments. In conclusion, the provision of interactive learning environments, diverse social network opportunities and, moreover, maintaining social support and nurturing cultural integration, would greatly promote social integration and benefit international medical students.
Testing non-inferiority of blended versus face-to-face Cognitive Behavioural Therapy for severe fatigue in patients with Multiple Sclerosis and the effectiveness of blended booster sessions aimed at improving long term outcome following both therapies: – study protocol for two observer-blinded randomized clinical trials
Authors: de Gier Marieke Houniet- , Beckerman Heleen , Vliet Kimberley van , Knoop Hans , de Groot Vincent 
Published: August 2019

Abstract
Background Cognitive behavioural therapy (CBT) has been found effective in reducing fatigue severity in MS patients directly following treatment. However, long-term effects are inconsistent leaving room for improvement. In addition, individual face-to-face CBT draws heavily on limited treatment capacity, and the travel distance to the treatment centre can be burdensome for patients. Therefore, we developed “MS Fit”, a blended CBT for MS-related fatigue, based on a face-to-face CBT protocol found effective in a previous study, and “MS Stay Fit”, internet-based booster sessions to improve long term effectiveness of CBT for MS-related fatigue. This paper presents the protocol of two Randomised Clinical Trials (RCTs) conducted within one study investigating 1) the non-inferiority of MS Fit compared to evidence-based face-to-face CBT for MS-related fatigue, and 2) the effectiveness of MS Stay Fit on the long-term outcome of fatigue compared to no booster sessions. Methods/design The first part of this study is an observer-blinded non-inferiority multicentre RCT, in which 166 severely fatigued MS patients will be randomized (1:1 ratio, computer-generated sequence) to either face-to-face CBT or blended CBT (MS Fit) for fatigue. The primary endpoint is at 20 weeks after baseline. After this post-treatment assessment, patients will be randomized again (1:1 ratio, computer generated sequence) to either MS Stay Fit consisting of 2 booster sessions at 2 and 4 months after end of treatment, or no booster sessions. The primary endpoint of the second study is 52 weeks after baseline. Primary outcome measure in both studies is fatigue severity assessed with the fatigue severity subscale of the Checklist Individual Strength (CIS20r). Outcomes will be assessed at baseline (T0), end of treatment (T20), after 39 and 52 weeks (T39 and T52). Discussion If MS Fit is found to be non-inferior to face-to-face CBT it will improve the accessibility of this treatment. In addition, the study aims to test if it is possible to improve long-term effectiveness of CBT for MS-related fatigue with MS Stay Fit.
Relationships of Internet Gaming Reasons to Biological Indicators and Risk of Internet Gaming Addiction in Korean Adolescent Male Game Users
Authors: Kim Nahyun , Kim Mi Ja , Hughes Tonda L. , Kwak Hyeweon , Kong In Deok 
Published: August 2019

Abstract
Background: There are no standard diagnostic criteria or interventions for internet gaming addiction (IGA) even though IGA is one of the most pervasive public health issues among youth worldwide. Internet gaming reasons or motivations have been studied as a potential predictor of IGA, but the results have been inconsistent and biological indicators of gaming reasons have rarely been studied. We sought to (1) identify categories of internet gaming reasons, (2) examine the relationship of gaming reasons to risk of IGA, and (3) describe biological indicators of gaming reasons.

Methods: We used a multi-phase cross-sectional design including individual interviews; focus group discussion; and descriptive, comparative analysis. Fifteen Korean adolescent male internet gamers participated in individual interviews and eight participated in a focus group aimed at identifying reasons for internet gaming. Using the identified gaming reasons from these sources we surveyed 225 adolescent game users using a self-report questionnaire. Participants provided blood samples for assessment of norepinephrine (NE) and serum cortisol.

Results: We identified four major categories of internet gaming reasons: entertainment, getting along with friends, stress relief, and habitual gaming. The habitual group showed significantly greater risk of IGA than the other groups (p<.001) and the lowest plasma NE levels (p=.035), possibly indicating an alteration in autonomic function.

Conclusion: Health care providers are encouraged to screen adolescents for excessive internet gaming and to intervene with those who report habitual gaming behaviors. When feasible, assessment of biological indicators, such as plasma NE, may help to identify youth at greatest risk of IGA.
Social networks and quality of life among female breast cancer patients at Tikur Anbessa Specialzed Hospital, Addis Ababa, Ethiopia 2019
Authors: Aberaraw Rahle , Yeshambel Addisu , Boka Abdisa , Teshome Roza 
Published: August 2019

Abstract
Background

Breast cancer is a major life-threatening public health problem in the world. It is the most common form of cancer among women in many developing countries including Ethiopia. Social networks could change the course of cancer and can influence the quality of life among breast cancer patients. Therefore, the purpose of this study was to assess social networks and quality of life among female breast cancer patients attending in Tikur Anbassa Specialized Hospital, Addis Ababa, Ethiopia 2019.

Methods

An institutional based cross-sectional study was conducted in Tikur Anbessa Specialized Hospital Addis Ababa, Ethiopia from March to April 2019. A total of 214 female breast cancer patients were included and systematic sampling method was used. A structured and pre-tested questionnaire was used. Data entry was done using epi data-manager version 4.2. Data analysis was done using Statistical Package for the Social Sciences version 25. Binary and multiple logistic regression was used to show the association of social networks and quality of life. The strength of association was declared P-value <0.05 and 95%CI was used.

Result

A total of 214 women with breast cancer were recruited. The mean age was 41.85. Among total participants, 13(6%), 65(30%) and 136(64%) had limited, medium and diverse social networks respectively. Whereas, 198(92.52%) of them had affected quality of life. Participants who were illiterate were more likely to have affected quality of life by 3 times than who were more educated (AOR=3, 95%CI: 1.3,6.9, COR=4.8) and who had systematic therapy side effects were more likely to have affected QoL by 3.8 times than who had no systemic therapy side effect (AOR=3.8, 95%CI: 1.1,13, COR=4).

Conclusion and recommendation

In this study finding quality of life in breast cancer was low. Healthcare providers especially working at oncology department need to focus on addressing side effects of therapy and social networks which may help to improve quality of life of women with breast cancer.
The influence of cognitive schemas on the mixed anxiety-depressive symptoms of breast cancer patients
Authors: Bredicean Ana Cristina , Crăiniceanu Zorin , Oprean Cristina , Rivis Ioana Alexandra , Papavă Ion , Secosan Ica , Frandes Mirela , Giurgi-Oncu Catalina , Grujic Daciana 
Published: August 2019

Abstract
Background

The surgical treatment of breast cancer involves various psychological consequences, which differ according to individual characteristics. Our study aimed to identify the role that cognitive schemas had in triggering anxiety and depressive symptoms in patients diagnosed with breast cancer that underwent oncological and plastic surgery treatment.

Methods

64 female patients, diagnosed with breast cancer from an Oncology and Plastic Surgery Hospital, were selected to participate in this study between March-June 2018. They were divided into two groups: I. 28 patients who underwent mastectomy surgery; II. 36 patients, who required mastectomy and, subsequently, chose to undergo breast reconstruction surgery. We employed two assessment scales: the YSQ-S3 Cognitive Schema Questionnaire and the DASS-21 Depression, Anxiety, and Stress Scale.

Results

We concluded that participants who underwent mastectomy and breast reconstruction surgery employed cognitive schemas that did not generate symptoms of depression or anxiety. In contrast, the cognitive schemas found in the group of women who refused reconstructive breast surgery significantly correlated with the presence of anxiety-depressive symptoms. The cognitive schema domain of ‘disconnection and rejection' did not correlate reliably with the presence of anxiety-depressive symptoms for the group with breast reconstruction (Spearman's r = 0.091, p = 0.644), while for the other group the correlation was moderate-strong (Spearman’s r = 0.647, p < 0.01). Negative emotional schemas correlated significantly with the presence of anxiety-depressive symptoms (Spearman's r = 0.598, p < 0.01) in the group of participants without reconstructive surgery.

Conclusion

A correct identification of dysfunctional cognitive schemas and coping mechanisms at the commencement of the combined treatment in breast cancer patients could serve as an indicator for the evolution of their mental health, therefore assisting professionals in establishing the most suitable psychological, psychotherapeutic and psychiatric intervention plan.
Perioperative poor grip strength recovery is associated with 30-day complication rate after cardiac surgery discharge in middle-aged and older adults- an observational study
Authors: Fu Liyuan , Zhang Yuanyuan , Shao Bohan , Liu Xiangjing , Yuan Bo , Wang Zhengqing , Chen Tienan , Liu Zhigang , Liu Xiaocheng , Guo Qi 
Published: August 2019

Abstract
Background: Although perioperative care during heart surgery has improved considerably, the rate of postoperative complications has remained stable. It has not been concluded how to better apply grip strength to clinical, postoperative complications. So our study aimed at researching the best way for using grip value for predicting early postoperative complications.
Methods: Consider a total of 212 people with mean age 63.8±6.3 who underwent cardiac surgery included participated in our study. We analyzed the ROC curve of grip strength, grip/weight and grip recovery with complications, found the best cutoff point. Logistic regression confirmed the correlation between grip strength grouping and complications.
Results: We found that 36 people had 30-day complications. EuroSCORE were 2.15±1.52 and 2.42±1.58 in two groups. The area under the receiver-operating characteristic curve (AUC) of grip recovery take the most area (0.837, p<0.001), and the cutoff point was 83.92%. In logistic regression, lower grip recovery has higher risk impact on 30-day complications for 25.68 times than normal group, after adjusted surgery-related factors. After relisted characteristic information with grip recovery group, found that percentage of the estimated 6MWD (41.5 vs 48.3, p=0.028) and hospitalization time (7.2 vs 6.1, p=0.042) had worse trends in lower recovery group.
Conclusions: Poor grip recovery may be related to higher risk of postoperative complications within 30 days after cardiac surgery in middle-aged and older people independent of surgical risk. The results of this study provide a reference for the development of rehabilitation programs in the early postoperative recovery, and may also be a prognostic indicator for postoperative high-risk groups.
The impact of worksite nutrition and physical activity interventions on productivity, work performance and workability: A Systematic Review
Authors: Grimani Aikaterini , Aboagye Emmanuel , Kwak Lydia 
Published: August 2019

Abstract
Background

Healthy lifestyles play an important role in the prevention of premature death, chronic diseases, productivity loss and other social and economic concerns. However, worksite interventions to address issues of fitness and nutrition which include work-related outcomes are complex and thus challenging to implement and appropriately measure the effectiveness of. This systematic review investigated the impact of worksite nutrition and physical activity interventions, which include components aimed at worksite’s physical environment and organizational structure, on employees’ productivity, work performance and workability.

Methods

A systematic review that included randomized controlled trials and or non-randomized controlled studies was conducted. Medline, EMBASE.com, Cochrane Library and Scopus were searched until September 2016. Productivity, absenteeism, presenteeism, work performance and workability were the primary outcomes of our interest, while sedentary behavior and changes in other health-related behaviors were considered as secondary outcomes. Two reviewers independently screened abstracts and full-texts for study eligibility, extracted the data and performed a quality assessment using the Cochrane Collaboration Risk-of-Bias Tool for randomized trials and the Risk-of-Bias in non-randomized studies of interventions. Findings were narratively synthesized.

Results

Thirty-nine randomized control trials and non-randomized controlled studies were included. Nearly 28% of the included studies were of high quality, while 56% were of medium quality. The studies covered a broad range of multi-level and environmental-level interventions. Fourteen worksite nutrition and physical activity intervention studies yielded statistically significant changes on absenteeism (n=7), work performance (n=2), workability (n=3), productivity (n=1) and on both workability and productivity (n=1). Two studies showed effects on absenteeism only between subgroups.

Conclusions

The scientific evidence shows that it is possible to influence work-related outcomes, especially sickness absence, positively through health promotion efforts that include components aimed at the workplace’s physical work environment and organizational structure. In order to draw further conclusions regarding work-related outcomes in controlled high-quality studies, long-term follow-up using objective outcomes and/or quality assured questionnaires are required.

Registration number

PROSPERO CRD42017081837
Hospital-Based Back Surgery: Geospatial-Temporal, Explanatory, and Predictive Models
Authors: Fulton Lawrence , Kruse Clemens Scott 
Published: August 2019

Background
Hospital-based back surgery in the United States increased by 60% from January 2012 to December 2017, yet the supply of neurosurgeons remained relatively constant. During this time, adult obesity grew by 5%.

Objective
This study aimed to evaluate the demand and associated costs for hospital-based back surgery by geolocation over time to evaluate provider practice variation. The study then leveraged hierarchical time series to generate tight demand forecasts on an unobserved test set. Finally, explanatory financial, technical, workload, geographical, and temporal factors as well as state-level obesity rates were investigated as predictors for the demand for hospital-based back surgery.

Methods
Hospital data from January 2012 to December 2017 were used to generate geospatial-temporal maps and a video of the Current Procedural Terminology codes beginning with the digit 63 claims. Hierarchical time series modeling provided forecasts for each state, the census regions, and the nation for an unobserved test set and then again for the out-years of 2018 and 2019. Stepwise regression, lasso regression, ridge regression, elastic net, and gradient-boosted random forests were built on a training set and evaluated on a test set to evaluate variables important to explaining the demand for hospital-based back surgery.

Results
Widespread, unexplained practice variation over time was seen using geographical information systems (GIS) multimedia mapping. Hierarchical time series provided accurate forecasts on a blind dataset and suggested a 6.52% (from 497,325 procedures in 2017 to 529,777 in 2018) growth of hospital-based back surgery in 2018 (529,777 and up to 13.00% by 2019 [from 497,325 procedures in 2017 to 563,023 procedures in 2019]). The increase in payments by 2019 are estimated to be US $323.9 million. Extreme gradient-boosted random forests beat constrained and unconstrained regression models on a 20% unobserved test set and suggested that obesity is one of the most important factors in explaining the increase in demand for hospital-based back surgery.

Conclusions
Practice variation and obesity are factors to consider when estimating demand for hospital-based back surgery. Federal, state, and local planners should evaluate demand-side and supply-side interventions for this emerging problem.
Media Sosial Sebagai Sebuah Ruang Hiperealitas
Authors: Komala Elly 
Published: August 2019

ABSTRAK
Penelitian ini berjudul “Media sosial sebagai sebuah ruang hiperealitas; studi kasus pada Twitter”. Zaman modern ini internet sudah dianggap menjadi wadah berkunjung bagi masyarakat yang melek teknologi. Kebutuhan yang disediakan dalam internet mencakup berbagai varian dengan situs kunjungan yang berbeda. Serangkaian proses menempatkan sistem maya sebagai wadah penghubung dengan situs-situs sebagai perantaranya.
Teori yang digunakan adalah teori Simulasi/ Hiperealitas. Metode penelitian yang digunakan adalah metode penelitian kualitatif. Teknik pengumpulan data dilakukan melalui studi kepustakaan, observasi partisipan, dan wawancara dengan 3 orang informan.
Berdasarkan hasil penelitian, wawancara dan analisis yang telah peneliti lakukan mengenai media sosial sebagai sebuah ruang hiperalitas, maka dapat ditarik beberapa kesimpulan yakni media social Twitter telah memenuhi unsur-unsur sebagai sebuah ruang hiperealitas menurut teori hiperealitas Baudrilard.
KEUNGGULAN BERSAING INDUSTRI KREATIF KRIYA
Authors: Alexandri Mohammad Benny , Chan Arianis 
Published: August 2019

Industri kreatif adalah pendorong utama penciptaan pekerjaan, inovasi, dan inklusi sosial. Industri kreatif juga memiliki pengaruh penting dalam kekayaan suatu daerah. Tulisan ini bertujuan untuk melihat perkembangan industri kreatif, khususnya sub sektor kerajinan dan keunggulan bersaingnya. Desa Boneka Sukamulya telah berdiri sejak tahun 1990-an. Sebagai pusat industri, seperti Binong Jati, ada beberapa perintis utama pendirian di pusat industri boneka. Desa Boneka Sukamulya dipelopori oleh Haji Atang, karena ketika industri lain menurun secara drastis bisnis boneka buatan memiliki prospek peningkatan yang stabil dan cenderung positif. Metode penelitian yang digunakan dalam makalah ini adalah metode systematic mapping study dan Analisis SWOT (Kekuatan, Kelemahan, Peluang, Ancaman). Tujuan dari penelitian ini adalah, 1. Bagaimana kondisi saat ini Industri Kampung Boneka Sukamulya, 2. Apakah masalah yang dihadapi Industri Kampung Boneka Sukamulya, 3. Apakah keunggulan bersaing yang dapat diterapkan Industri Kampung Boneka Sukamulya dalam menghadapi permasalahan yang ada.. Kesimpulan untuk Desa Boneka Sukamulya adalah memiliki potensi besar. Potensi ini dapat berkontribusi besar terhadap pertumbuhan ekonomi kreatif dan lapangan kerja. Desa Boneka Sukamulya masih memiliki kendala yang harus dihadapi yaitu bahan baku dan pesaing.
Visions and plans for regional development in Ireland
Authors: Walsh James A. 
Published: August 2019

Abstract
The evolution of spatial planning in Ireland, and more widely, has been a complex process in which many narratives have been explored at different times. In 2018 the government published the National Planning Framework (NPF) to guide and support the achievement of a challenging and potentially transformative development strategy for Ireland 2040. The NPF is grounded in a vision that sets out to be disruptive of what has become embedded as the status quo in political, administrative and planning decision-making. While it is a very innovative addition to the portfolio of government policies and strategies, it is not the first time that radical visions have been proposed. This paper reviews previous visions and plans for regional development that have been proposed over the last seventy-five years, and critically compares and contrasts the approaches represented by the National Spatial Strategy (2002–20) and the NPF (2018–40), including the subsequent draft regional spatial and economic strategies. The implications of the population projections and the proposed settlement patterns for the achievement of the NPF objective of effective regional development, which is expressed as a regional parity target, are closely examined.