bluuebunny/crossref_metadata_2025_split huggingface dataset:
Partnering with Native Communities to Develop a Culturally Grounded Intervention for Substance Use Disorder
Authors: Skewes Monica C. , Hallum‐Montes Rachel , Gardner Scott A. , Blume Arthur W. , Ricker Adriann , FireMoon Paula 
Published: July 2019

AbstractStudies have documented serious disparities in drug and alcohol‐related morbidity and mortality among American Indians and Alaska Natives (AI/ANs) compared to other ethnic groups in the U.S. despite high rates of abstinence in these groups. Further complicating these health disparities are barriers to accessing evidence‐based treatments that are culturally appropriate and acceptable. As part of a research program to promote health equity in rural communities, we developed an academic‐community partnership to create a culturally grounded intervention for adults with substance use disorder (SUD) residing on a rural AI reservation. We describe the early phases of our long‐term Community Based Participatory Research project and report findings from the first study we conducted. This key informant interview study consisted of in‐depth qualitative interviews with 25 tribal members knowledgeable about substance use and recovery on the reservation. The goal was to understand social norms and cultural conceptualizations of substance use to inform the development of a sustainable, community‐driven intervention. Participants reported that a holistic approach to recovery that emphasizes spiritual, cultural, and interpersonal harmony and connectedness was important to the community and would be necessary for the intervention to succeed. They also emphasized the need for a multi‐level intervention targeting individuals, families, and the community as a whole. Through this initial study, we not only gained valuable information that will be used to guide future research and treatment efforts, but we also strengthened our partnership and built trust with the community. In this manuscript we tell the story of the development of our project and describe our shared vision for future directions.
Morphological integration affects the evolution of midline cranial base, lateral basicranium, and face across primates
Authors: Neaux Dimitri , Wroe Stephen , Ledogar Justin A. , Heins Ledogar Sarah , Sansalone Gabriele 
Published: July 2019

AbstractObjectivesThe basicranium and face are two integrated bony structures displaying great morphological diversity across primates. Previous studies in hominids determined that the basicranium is composed of two independent modules: the midline basicranium, mostly influenced by brain size, and the lateral basicranium, predominantly associated with facial shape. To better assess how morphological integration impacts the evolution of primate cranial shape diversity, we test to determine whether the relationships found in hominids are retained across the order.Materials and methodsThree‐dimensional landmarks (29) were placed on 143 computed tomography scans of six major clades of extant primate crania. We assessed the covariation between midline basicranium, lateral basicranium, face, and endocranial volume using phylogenetically informed partial least squares analyses and phylogenetic generalized least squares models.ResultsWe found significant integration between lateral basicranium and face and between midline basicranium and face. We also described a significant correlation between midline basicranium and endocranial volume but not between lateral basicranium and endocranial volume.DiscussionOur findings demonstrate a significant and pervasive integration in the craniofacial structures across primates, differing from previous results in hominids. The uniqueness of module organization in hominids may explain this distinction. We found that endocranial volume is significantly integrated to the midline basicranium but not to the lateral basicranium. This finding underlines the significant effect of brain size on the shape of the midline structures of the cranial base in primates. With the covariations linking the studied features defined here, we suggest that future studies should focus on determining the causal links between them.
An Intracerebral Hemorrhage Care Bundle Is Associated with Lower Case Fatality
Authors: Parry‐Jones Adrian R. , Sammut‐Powell Camilla , Paroutoglou Kyriaki , Birleson Emily , Rowland Joshua , Lee Stephanie , Cecchini Luca , Massyn Mark , Emsley Richard , Bray Benjamin , Patel Hiren 
Published: July 2019

ObjectiveAnticoagulation reversal, intensive blood pressure lowering, neurosurgery, and access to critical care might all be beneficial in acute intracerebral hemorrhage (ICH). We combined and implemented these as the “ABC” hyperacute care bundle and sought to determine whether the implementation was associated with lower case fatality.MethodsThe ABC bundle was implemented from June 1, 2015 to May 31, 2016. Key process targets were set, and a registry captured consecutive patients. We compared 30‐day case fatality before, during, and after bundle implementation with multivariate logistic regression and used mediation analysis to determine which care process measures mediated any association. Difference‐in‐difference analysis compared 30‐day case fatality with 32,295 patients with ICH from 214 other hospitals in England and Wales using Sentinel Stroke National Audit Programme data.ResultsA total of 973 ICH patients were admitted in the study period. Compared to before implementation, the adjusted odds of death by 30 days were lower in the implementation period (odds ratio [OR] = 0.62, 95% confidence interval [CI] = 0.38–0.97, p = 0.03), and this was sustained after implementation (OR = 0.40, 95% CI = 0.24–0.61, p < 0.0001). Implementation of the bundle was associated with a 10.8 percentage point (95% CI = −17.9 to −3.7, p = 0.003) reduction in 30‐day case fatality in difference‐in‐difference analysis. The total effect of the care bundle was mediated by a reduction in do‐not‐resuscitate orders within 24 hours (52.8%) and increased admission to critical care (11.1%).InterpretationImplementation of the ABC care bundle was significantly associated with lower 30‐day case fatality after ICH. ANN NEUROL 2019;86:495–503
A Facile Molecular Machine: Optically Triggered Counterion Migration by Charge Transfer of Linear Donor‐π‐Acceptor Phosphonium Fluorophores
Authors: Belyaev Andrey , Cheng Yu‐Hsuan , Liu Zong‐Ying , Karttunen Antti J. , Chou Pi‐Tai , Koshevoy Igor O. 
Published: July 2019

AbstractThe D‐π‐A type phosphonium salts in which electron acceptor (A=‐+PR3) and donor (D=‐NPh2) groups are linked by polarizable π‐conjugated spacers show intense fluorescence that is classically ascribed to excited‐state intramolecular charge transfer (ICT). Unexpectedly, salts with π=‐(C6H4)n‐ and ‐(C10H6C6H4)‐ exhibit an unusual dual emission (F1 and F2 bands) in weakly polar or nonpolar solvents. Time‐resolved fluorescence studies show a successive temporal evolution from the F1 to F2 emission, which can be rationalized by an ICT‐driven counterion migration. Upon optically induced ICT, the counterions move from ‐+PR3 to ‐NPh2 and back in the ground state, thus achieving an ion‐transfer cycle. Increasing the solvent polarity makes the solvent stabilization dominant, and virtually stops the ion migration. Providing that either D or A has ionic character (by static ion‐pair stabilization), the ICT‐induced counterion migration should not be uncommon in weakly polar to nonpolar media, thereby providing a facile avenue for mimicking a photoinduced molecular machine‐like motion.
Gezielte Singulett‐Sauerstofferzeugung durch bioorthogonale DNA‐basierte Tetrazin‐Ligation
Authors: Linden Greta , Zhang Lei , Pieck Fabian , Linne Uwe , Kosenkov Dmitri , Tonner Ralf , Vázquez Olalla 
Published: July 2019

AbstractWir berichten über die Verwendung von bioorthogonalen Reaktionen als innovative Strategie in der photodynamischen Therapie, um gleichzeitig eine gezielte Phototoxizität und eine spezifische subzelluläre Lokalisation zu erreichen. Unsere neuartigen halogenierten BODIPY‐Tetrazin‐Sonden werden in Gegenwart eines geeigneten Dienophils über eine intrazelluläre Diels‐Alder‐Reaktion mit inversem Elektronenbedarf zu effizienten Photosensibilisatoren (ΦΔ≈0.50). Ab‐initio‐Berechnungen zeigen eine aktivierungsabhängige Änderung der Zerfallskanäle, die die 1O2‐Erzeugung steuern. Unser bioorthogonaler Ansatz ermöglicht weiterhin eine räumliche Kontrolle. Als Proof‐of‐Concept demonstrieren wir hier die Möglichkeit einer selektiven Aktivierung unseres ruhenden Photosensibilisators im Zellkern, der dann bei Bestrahlung zum Absterben von Krebszellen führt. So eröffnen unsere dualen bioorthogonal aktivierbaren Photosensibilisatoren neue Möglichkeiten, um die gegenwärtigen Begrenzungen der photodynamischen Therapie zu überwinden.
Reactions of 2‐Aryl‐1,3‐Dithianes and [1.1.1]Propellane
Authors: Trongsiriwat Nisalak , Pu Youge , Nieves‐Quinones Yexenia , Shelp Russell A. , Kozlowski Marisa C. , Walsh Patrick J. 
Published: July 2019

AbstractBicyclo[1.1.1]pentanes (BCPs) have sparked the interest of medicinal chemists due to their recent discovery as bioisosteres of aromatic rings. To study the biological activity of this relatively new class of bioisosteres, reliable methods to incorporate BCPs into target molecules are in high demand, as reflected by a flurry of methods for BCP synthesis in recent years. In this work, we disclose a general method for the synthesis of BCP‐containing dithianes which, upon deprotection, provide access to BCP analogues of medicinally abundant diarylketones. A broad scope of 2‐aryl‐1,3‐dithianes, including several heterocyclic derivatives, react with [1.1.1]propellane to afford 26 new derivatives in good to excellent yields. Further transformation of the dithiane portion into a variety of functional groups demonstrates the robustness of the products. A computational study indicates that the reaction of 2‐aryl‐1,3‐dithianes and [1.1.1]propellane proceeds via a two‐electron pathway.
A Potent Halogen‐Bonding Donor Motif for Anion Recognition and Anion Template Mechanical Bond Synthesis
Authors: Bunchuay Thanthapatra , Docker Andrew , Martinez‐Martinez Antonio J. , Beer Paul D. 
Published: July 2019

AbstractThe covalent attachment of electron deficient perfluoroaryl substituents to a bis‐iodotriazole pyridinium group produces a remarkably potent halogen bonding donor motif for anion recognition in aqueous media. Such a motif also establishes halogen bonding anion templation as a highly efficient method for constructing a mechanically interlocked molecule in unprecedented near quantitative yield. The resulting bis‐perfluoroaryl substituted iodotriazole pyridinium axle containing halogen bonding [2]rotaxane host exhibits exceptionally strong halide binding affinities in competitive 50 % water containing aqueous media, by a factor of at least three orders of magnitude greater in comparison to a hydrogen bonding rotaxane host analogue. These observations further champion and advance halogen bonding as a powerful tool for recognizing anions in aqueous media.
Proton‐Coupled Electron Transfer Induced by Near‐Infrared Light
Authors: Enomoto Takafumi , Kondo Mio , Masaoka Shigeyuki 
Published: July 2019

AbstractA proton‐coupled electron transfer reaction induced by near‐infrared light (>710 nm) has been achieved using a dye that shows intense NIR absorption property and electron/proton‐accepting abilities. The developed system generated long‐lived radical species and showed high reversibility and robustness. Mechanistic investigations suggested that the rate‐determining step of the reaction involves the proton transfer process.
Creating Faradaic Carbon Nanotube Electrodes with Mild Chemical Oxidation
Authors: Emmett Robert K. , Kowalske Michael J. , Mou Hansen , Grady Mikaela , Jiang Han , Roberts Mark E. 
Published: July 2019

AbstractThe development of new materials to improve interfacial charge transfer characteristics will drastically improve energy storage, heterogeneous catalysis, and many other electrochemical applications. Here, we report a simple procedure that can harness the Faradaic nature of residual iron nanoparticle catalysts that endure within multi‐walled carbon nanotubes (MWNT) post‐synthesis, thereby alleviating the challenges associated with forging hybrid nanocomposite electrodes. Non‐purified MWNTs, undergo a chemical oxidation process in acidic conditions with KMnO4 to partially “unzip” the MWNTs and expose the redox‐active iron nanoparticles to the electrolyte. A stable redox peak associated with the Fe2+/3+ transition is achieved during the MWNT oxidation process yielding a ∼350 % increase in capacitance (>300 F g−1) relative to purified MWNT electrodes (70 F g−1). While these materials solely may be pragmatic as energy storage electrodes, the integration of redox species within an inert carbon electrode will also provide new opportunities to accelerate heterogeneous charge transfer reactions.
Switchable Ring‐Opening Polymerization by a Ferrocene Supported Aluminum Complex
Authors: Lai Amy , Hern Zachary C. , Diaconescu Paula L. 
Published: July 2019

AbstractAn aluminum(III) iso‐propoxide complex supported by salfen (1, salfen=1,1′‐di(2,4‐bis‐tert‐butyl‐salicylimino)ferrocene) was synthesized and characterized. Compound 1 can be reversibly oxidized and reduced, and both redox species were surveyed as ring‐opening polymerization catalysts for cyclic esters and cyclohexene oxide. Based on the observed reactivity behavior, 1 could be used as a redox‐switchable catalyst for the formation of AB and ABC type di‐ and triblock copolymers of lactide, cyclohexene oxide, and trimethylene carbonate.
Rational Synthesis, Structures and Properties of the Ionic Liquid Binary Iodine‐Bromine Octahalide Series [InBr8−n]2− (n=0, 2, 3, 4)
Authors: Abdelbassit Mohammed S. , Curnow Owen J. , Dixon Miriam K. , Waterland Mark R. 
Published: July 2019

AbstractA series of octanuclear iodine‐bromine interhalides [InBr8−n]2− (n=0, 2, 3, 4) were prepared systematically in two steps. Firstly, addition of a dihalogen (Br2 or IBr) to the triaminocyclopropenium bromide salt [C3(NEt2)3]Br forms the corresponding trihalide salt with Br3− or IBr2− anions, respectively. Secondly, addition to Br3− of half an equivalent of Br2 gives the octabromine polyhalide [Br8]2−, whereas addition to IBr2− of half an equivalent of Br2, IBr or I2 gives the corresponding interhalides: [I2Br6]2−, [I3Br5]2−, and [I4Br4]2−, respectively. The four octahalides were characterized by X‐ray crystallography, computational studies, Raman and Far‐IR spectroscopies, as well as by TGA and melting point. All of the salts were found to be ionic liquids.
The Binary Iodine‐Chlorine Octahalide Series [InCl8−n]2− (n=3, 3.6, 4)
Authors: Abdelbassit Mohammed S. , Curnow Owen J. , Dixon Miriam K. , Waterland Mark R. 
Published: July 2019

AbstractThe octanuclear iodine‐chlorine interhalides [I4Cl4]2− and [I3Cl5]2− were prepared in two steps. Firstly, addition of ICl to the triaminocyclopropenium chloride salt [C3(NEt2)3]Cl forms the trihalide ICl2− salt, secondly, addition of half an equivalent of I2 or ICl, respectively, gave the desired products upon crystallization at low temperature. The non‐stoichiometric octahalide [I3.6Cl4.4]2− was obtained after heating a CH2Cl2 solution of the ICl2− salt to reflux for 2 hours followed crystallization. [I4Cl4]2− is best described as two ICl2− anions bridged by I2, whereas [I3Cl5]2− is best described as an [I2Cl3]− pentahalide with a weak halogen bond to an ICl2− trihalide. The octahalides were characterized by X‐ray crystallography, computational studies, Raman and Far‐IR spectroscopies, as well as by TGA and melting point.
N2O‐Vermeidung bei der Behandlung hoch stickstoffreicher Abwässer
Authors: Lindenblatt Claus , Drewes Jörg E. 
Published: July 2019

AbstractBezogen auf den Stickstoffabbau zeigen die N2O‐Emissionen große Unterschiede bei der zweistufigen Behandlung mit Nitritation als erster Stufe gegenüber der einstufigen Deammonifikation. Es sind Messergebnisse der Nitritation im Kontaktprozess mit kontinuierlicher Beschickung und Nachklärung sowie der Behandlung im Sequencing‐Batch‐Reaktor gegenübergestellt. Während der biologischen Zentratbehandlung wurden N2O‐Konzentrationen in Reaktoren und der Abluft gemessen. Bei ähnlicher NH4‐N‐Abbauleistung liegen die N2O‐Emissionen in der einstufigen Deammonifikation um eine Zehnerpotenz niedriger.
PROTOCOL: COURT‐MANDATED INTERVENTIONS FOR INDIVIDUALS CONVICTED OF DOMESTIC VIOLENCE: A Campbell Collaboration Systematic Review
Authors: Feder Lynette , Wilson David B. 
Published: July 2019

AbstractBackground: Survey research and analysis of police records, hospital emergency rooms and women's shelters have clearly established the severity of the domestic violence problem and the need to find programs to address this issue. Today, court‐mandated batterer intervention programs (BIPs) are being implemented throughout the United States as one of the leading methods to address this problem. These programs emerged from the women's shelter movement and therefore contained a strong feminist orientation. They developed as group‐based programs, typically using psychoeductional methods. Their aim was to get men to take responsibility for their sexist beliefs and stop abusing their partners by teaching them alternative responses for handling their anger.Objectives: The aim of this systematic review is to assess the effects of post‐arrest court‐mandated interventions (including pre‐trial diversion programs) for domestic violence offenders that target, in part or exclusively, batterers with the aim of reducing their future likelihood of re‐assaulting above and beyond what would have been expected by routine legal procedures.Search Strategies: We plan to search numerous computerized databases and websites, bibliographies of published reviews of related literature and scrutinize annotated bibliographies of related literature. Our goal is to identify all published and unpublished literature that met our selection criteria.Selection Criteria: We plan to include experimental or rigorous quasi‐experimental evaluations of court‐mandated batter intervention programs that measured official or victim reports of future domestic violent behavior. Rigorous quasi‐experimental designs are defined as those that either use matching or statistical controls to improve the comparability of the groups. Given their importance in the literature, we will also include rigorous quasi‐experimental designs that used a treatment drop‐out comparison.Data Collection and Analysis: We plan to code characteristics of the treatment, sample, outcomes, and research methods. Findings will be extracted in the form of an effect size and effect sizes will be analyzed using the inverse‐variance method of meta‐analysis. Official report and victim report outcomes will be analyzed separately as will be the different design types (i.e, random, quasi‐experimental with a no treatment comparison, and quasi‐experimental with a treatment dropout comparison).
PROTOCOL: On the Malleability of Self‐Control: Theoretical and Policy Implications Regarding a General Theory of Crime
Authors: Piquero Alex R. , Jennings Wesley G. , Farrington David P. 
Published: July 2019

AbstractGottfredson and Hirschi's general theory of crime has generated significant controversy and research, such that there now exists a large knowledge base regarding the importance of self‐control in regulating antisocial behavior over the life course. Reviews of this literature indicate that self‐control is an important correlate of antisocial activity. There has been some research examining programmatic efforts designed to examine the extent to which self‐control is malleable, but little empirical research on this issue has been carried out within criminology, largely because the theorists have not paid much attention to policy proscriptions. This study evaluates the extant research on the effectiveness of programs designed to improve self‐control up to age 10 among children and adolescents, and assesses the effects of these programs on self‐control and delinquency/crime.
Synthesis of gold nanoparticles dispersion in toluene using immiscible fluid flow in microfluidic device
Authors: Hamamoto Mao , Liang Yiyang , Yagyu Hiromasa 
Published: July 2019

AbstractA synthesis of gold nanoparticles dispersion in toluene by mixing immiscible solutions in a microchannel was proposed. The visualization test using red and blue ink aqueous solutions as a substitute for gold ion and reducing agent confirmed that the fluid showed the slug flow at below the flow rate of 0.3 mL/min. The synthesis results found that gold nanoparticles with diameter from 3.0 to 4.1 nm was prepared at slug flow in the microchannel, and size control of gold nanoparticle enable by changing the flow rate.
Pattern and scale: evaluating generalities in crab distributions and marsh dynamics from small plots to a national scale
Authors: Wasson Kerstin , Raposa Kenneth , Almeida Monica , Beheshti Kathryn , Crooks Jeffrey A. , Deck Anna , Dix Nikki , Garvey Caitlin , Goldstein Jason , Johnson David Samuel , Lerberg Scott , Marcum Pamela , Peter Christopher , Puckett Brandon , Schmitt Jenni , Smith Erik , Laurent Kari St. , Swanson Katie , Tyrrell Megan , Guy Rachel 
Published: July 2019

AbstractThe generality of ecological patterns depends inextricably on the scale at which they are examined. We investigated patterns of crab distribution and the relationship between crabs and vegetation in salt marshes at multiple scales. By using consistent monitoring protocols across 15 U.S. National Estuarine Research Reserves, we were able to synthesize patterns from the scale of quadrats to the entire marsh landscape to regional and national scales. Some generalities emerged across marshes from our overall models, and these are useful for informing broad coastal management policy. We found that crab burrow distribution within a marsh could be predicted by marsh elevation, distance to creek and soil compressibility. While these physical factors also affected marsh vegetation cover, we did not find a strong or consistent overall effect of crabs at a broad scale in our multivariate model, though regressions conducted separately for each site revealed that crab burrows were negatively correlated with vegetation cover at 4 out of 15 sites. This contrasts with recent smaller‐scale studies and meta‐analyses synthesizing such studies that detected strong negative effects of crabs on marshes, likely because we sampled across the entire marsh landscape, while targeted studies are typically limited to low‐lying areas near creeks, where crab burrow densities are highest. Our results suggest that sea‐level rise generally poses a bigger threat to marshes than crabs, but there will likely be interactions between these physical and biological factors. Beyond these generalities across marshes, we detected some regional differences in crab community composition, richness, and abundance. However, we found striking differences among sites within regions, and within sites, in terms of crab abundance and relationships to marsh integrity. Although generalities are broadly useful, our findings indicate that local managers cannot rely on data from other nearby systems, but rather need local information for developing salt marsh management strategies.
Bimodal Probe for Magnetic Resonance Imaging and Photoacoustic Imaging Based on a PCTA‐Derived Gadolinium(III) Complex and ZW800–1
Authors: Devreux Marie , Henoumont Céline , Dioury Fabienne , Stanicki Dimitri , Boutry Sébastien , Larbanoix Lionel , Ferroud Clotilde , Muller Robert N. , Laurent Sophie 
Published: July 2019

AbstractInvited for the cover of this issue is the group of Sophie Laurent from the University of Mons, Belgium. The cover image shows a blood vessel containing the bimodal probe reported in this paper.