bluuebunny/crossref_metadata_2025_split huggingface dataset:
Suzy's Gold Star: A Holistic Education in Steinbeck's Sweet Thursday
Authors: Amiro Kristen D. 
Published: June 2018

Abstract
In this article, I analyze Suzy and Fauna's pedagogical relationship in Sweet Thursday as an example of holistic education. I argue that through this relationship, Steinbeck's holistic worldview is illuminated, a worldview consistent with the ideas of Jiddu Krishnamurti, an educator, thinker, and Steinbeck contemporary. Steinbeck and Krishnamurti's core beliefs about the importance of relationships and the development of the self are central themes of holistic education. Holistic education is informed by ecological thinking and takes into account the student as a whole person in relation to others. In this light I examine Fauna's teaching style and the content of her lessons, which relate to awareness. Once Suzy's awareness is ignited, she grows holistically, extending her potential and becoming more integrated into the community. As she evolves, Suzy personifies Krishnamurti's ideal of developing awareness in relation to the environment. To a lesser extent, but still through a Krishnamurti lens, I examine the character of Doc as another teacher-figure and learner, whose nagging problem of loneliness is resolved through community, reflection, and self-awareness.
Intein-mediated backbone cyclization of entolimod confers enhanced radioprotective activity in mouse models
Authors: Ye Bingyu , Shen Wenlong , Shi Minglei , Zhang Yan , Xu Cunshuan , Zhao Zhihu 
Published: June 2018

Background
Entolimod is a Salmonella enterica flagellin derivate. Previous work has demonstrated that entolimod effectively protects mice and non-human primates from ionizing radiation. However, it caused a “flu-like” syndrome after radioprotective and anticancer clinical application, indicating some type of immunogenicity and toxicity. Cyclization is commonly used to improve the in vivo stability and activity of peptides and proteins.

Methods
We designed and constructed cyclic entolimod using split Nostoc punctiforme DnaE intein with almost 100% cyclization efficiency. We adopted different strategies to purify the linear and circular entolimod due to their different topologies. Both of linear and circular entolimod were first purified by Ni-chelating affinity chromatography, and then the linear and circular entolimod were purified by size-exclusion and ion-exchange chromatography, respectively.

Results
The circular entolimod showed significantly increased both the in vitro NF-κB signaling and in vivo radioprotective activity in mice.

Conclusion
Our data indicates that circular entolimod might be a good candidate for further clinical investigation.
Polymer‐Bound Supramolecular J‐Aggregates: Optical Properties and Applications
Authors: Sorokin Alexander V. , Yefimova Svitlana L. , Malyukin Yuriy V. 
Published: June 2018

AbstractLuminescent molecular aggregates, called J‐aggregates, are an interesting example of supramolecular structures with a number of unique spectral properties. Their optical properties are governed by the excitonic nature resulting from high‐order molecular packing in the J‐aggregate chains. The J‐aggregate characteristic feature is the bathochromically shifted narrow excitonic band termed the J‐band. The optical properties of J‐aggregates are markedly distinct from those of the individual molecules forming the aggregate, namely narrow absorption band, high oscillator strength, giant third‐order susceptibility, resonant luminescence, and effective exciton diffusion. Although solutions of J‐aggregates often possess low photostability for practical usage, their solid samples are more convenient, especially different polymer films due to their ease of preparation and availability of application. J‐aggregate formation in polymer films has both advantages and disadvantages: Some spectral characteristics could degrade, whereas composites creation could modify and improve their optical properties. This article aims to demonstrate how the interaction of J‐aggregates with polymers in both solution and solid film state affects their spectral properties. In addition, examples of composites and devices based on polymer‐bound J‐aggregates are discussed.
Intentional Weight Loss in Overweight and Obese Patients With Knee Osteoarthritis: Is More Better?
Authors: Messier Stephen P. , Resnik Allison E. , Beavers Daniel P. , Mihalko Shannon L. , Miller Gary D. , Nicklas Barbara J. , deVita Paul , Hunter David J. , Lyles Mary F. , Eckstein Felix , Guermazi Ali , Loeser Richard F. 
Published: June 2018

ObjectiveTo determine the dose response effect of weight loss on clinical and mechanistic outcomes in overweight and obese adults with knee osteoarthritis (OA).MethodsThis is a secondary analysis of the diet‐induced weight loss only (D) and diet‐induced weight loss plus exercise (D + E) groups in the Intensive Diet and Exercise for Arthritis randomized controlled clinical trial. The 240 participants were overweight and obese older community‐dwelling adults with pain and radiographic knee OA. Participants were assigned to 1 of 4 groups according to weight loss achieved over an 18‐month period: <5% (<5% group), 5–10% (≥5% group), 10–20% (≥10% group), and >20% (≥20% group).ResultsThere were significant dose responses to weight loss for pain (P = 0.01), function (P = 0.0006), 6‐minute walk distance (P < 0.0001), physical (P = 0.0004) and mental (P = 0.03) health‐related quality of life (HRQoL), knee joint compressive force (P < 0.0001), and interleukin‐6 (P = 0.002). Greater weight loss resulted in superior clinical and mechanstic outcomes, with the highest weight loss group (≥20% group) distinguishing itself on all measures compared with the <5% and ≥5% groups; the ≥20% group had 25% less pain and better function compared with the ≥10% group and significantly (P = 0.006) better physical HRQoL.ConclusionLong‐term weight loss of 10–19.9% of baseline body weight has substantial clinical and mechanistic benefits compared with less weight loss. The value of an additional 10% weight loss includes significantly improved physical HRQoL and a clinically important reduction of pain and improvement in function.
Bridging Systemic Immunity with Gastrointestinal Immune Responses via Oil‐in‐Polymer Capsules
Authors: Xia Yufei , Wu Jie , Du Yiqun , Miao Chunyu , Su Zhiguo , Ma Guanghui 
Published: June 2018

AbstractAs peripheral lymphocytes are typically excluded from the gastrointestinal lymph tissues, current parenteral vaccinations fail to simultaneously induce systemic and mucosal responses. To break the natural barrier, “immunoticket” capsules are developed and heralded, which are designed with positive charged shells and oily core to spatiotemporally deliver antigens and all‐trans retinoic acid (RA). After intramuscular vaccinations, these capsules function as an immunoticket to cultivate peripheral dendritic cells (DCs) with gut‐homing receptors (CCR9). By hitchhiking on the concentration gradient of the CC‐motif chemokine ligand 25 (CCL25), the primed DCs would home to the gut associated lymphoid tissues (GALTs) and induce antigen‐specific IgA secretion and T cell engagements. Compared with the currently employed RA‐involving formulations, the immunoticket capsules stimulate enhanced RA‐mediated gut‐tropism by mounting the inflammatory innate immunity. Through controlling the RA payload, the potential regulatory T cell engagement is circumvented. In ovalbumin (OVA) and EV71 vaccinations, the immunoticket capsules induce potent serum IgG titer and antigen‐specific cytotoxic T cells in the peripheral lymph tissues, as well as robust IgA secretion and T cell engagements on gastrointestinal sites. The data suggest the potential of the immunotickets to serve as a facile, effective, and safe strategy to provide comprehensive immune responses against gastrointestinal infections and diseases
Bias‐Polarity Dependent Bidirectional Modulation of Photonic Bandgap in a Nanoengineered 3D Blue Phase Polymer Scaffold for Tunable Laser Application
Authors: Wang Meng , Zou Cheng , Li Chenyue , Sun Jian , Wang Ling , Hu Wei , Zhang Cuihong , Zhang Lanying , He Wanli , Yang Huai 
Published: June 2018

AbstractTransferring self‐assembly liquid‐crystalline blue phase structure to polymers is emerging as a promising bottom‐up strategy in the nanofabrication of 3D photonic materials and devices. Here a polymer scaffold in blue phase I structure is fabricated with cubic symmetry and its potential application is demonstrated as an electrically tunable mirrorless laser by refilling the scaffold with laser dye‐doped nematic liquid crystal mixture. The templated blue phase exhibits immense thermal stability and sensitive responsive behavior to external electric fields with blueshift of the reflection band under negative bias voltage whereas redshift under positive bias. Moreover, bias‐polarity dependent bidirectional tuning of the laser emission with wavelength range of about 48 nm is achieved in the study. The nanoengineered 3D polymer scaffold with splendid electrical tunability might provide impetus for the preparation of functional hybrid materials and novel device architectures, which have diversified potential applications in reflective full‐color displays, tunable optical devices, and photonic integrated circuits.
A Polyketide Synthase Component for Oxygen Insertion into Polyketide Backbones
Authors: Meoded Roy A. , Ueoka Reiko , Helfrich Eric J. N. , Jensen Katja , Magnus Nancy , Piechulla Birgit , Piel Jörn 
Published: June 2018

AbstractEnzymatic core components from trans‐acyltransferase polyketide synthases (trans‐AT PKSs) catalyze exceptionally diverse biosynthetic transformations to generate structurally complex bioactive compounds. Here we focus on a group of oxygenases identified in various trans‐AT PKS pathways, including those for pederin, oocydins, and toblerols. Using the oocydin pathway homologue (OocK) from Serratia plymuthica 4Rx13 and N‐acetylcysteamine (SNAC) thioesters as test surrogates for acyl carrier protein (ACP)‐tethered intermediates, we show that the enzyme inserts oxygen into β‐ketoacyl moieties to yield malonyl ester SNAC products. Based on these data and the identification of a non‐hydrolyzed oocydin congener with retained ester moiety, we propose a unified biosynthetic pathway of oocydins, haterumalides, and biselides. By providing access to internal ester, carboxylate pseudostarter, and terminal hydroxyl functions, oxygen insertion into polyketide backbones greatly expands the biosynthetic scope of PKSs.
Enhancement of Peroxidase Activity in Artificial Mimochrome VI Catalysts through Rational Design
Authors: Caserta Giorgio , Chino Marco , Firpo Vincenzo , Zambrano Gerardo , Leone Linda , D'Alonzo Daniele , Nastri Flavia , Maglio Ornella , Pavone Vincenzo , Lombardi Angela 
Published: June 2018

AbstractRational design provides an attractive strategy to tune and control the reactivity of bioinspired catalysts. Although there has been considerable progress in the design of heme oxidase mimetics with active‐site environments of ever‐growing complexity and catalytic efficiency, their stability during turnover is still an open challenge. Herein, we show that the simple incorporation of two 2‐aminoisobutyric acids into an artificial peptide‐based peroxidase results in a new catalyst (FeIII‐MC6*a) with higher resistance against oxidative damage and higher catalytic efficiency. The turnover number of this catalyst is twice as high as that of its predecessor. These results point out the protective role exerted by the peptide matrix and pave the way to the synthesis of robust bioinspired catalysts.
Quinoline–Glycomimetic Conjugates Reducing Lipogenesis and Lipid Accumulation in Hepatocytes
Authors: Palit Subhadeep , Mukherjee Sanghamitra , Niyogi Sougata , Banerjee Anindyajit , Patra Dipendu , Chakraborty Amit , Chakrabarti Saikat , Chakrabarti Partha , Dutta Sanjay 
Published: June 2018

AbstractNonalcoholic fatty liver disease (NAFLD), which is characterized by excess accumulation of triglyceride in hepatocytes, is the major cause of chronic liver disease worldwide and no approved drug is available. The mechanistic target of rapamycin (mTOR) complexes has been implicated in promoting lipogenesis and fat accumulation in the liver, and thus, serve as attractive drug targets. The generation of non‐ or low cytotoxic mTOR inhibitors is required because existing cytotoxic mTOR inhibitors are not useful for NAFLD therapy. New compounds based on the privileged adenosine triphosphate (ATP) site binder quinoline scaffold conjugated to glucose and galactosamine derivatives, which have significantly low cytotoxicity, but strong mTORC1 inhibitory activity at low micromolar concentrations, have been synthesized. These compounds also effectively inhibit the rate of lipogenesis and lipid accumulation in cultured hepatocytes. This is the first report of glycomimetic–quinoline derivatives that reduce lipid load in hepatocytes.
Median arcuate ligament syndrome and aneurysm in the pancreaticoduodenal artery detected by retroperitoneal hemorrhage: A case report
Authors: Hanaki Takehiko , Fukuta Shiori , Okamoto Masaru , Tsuda Ayumi , Yagyu Takuki , Urushibara Shoichi , Endo Kanenori , Suzuki Kazunori , Nakamura Seiichi , Ikeguchi Masahide 
Published: June 2018

Key Clinical MassageHere, we report a case with successful treatment of inferior pancreaticoduodenal artery aneurysm rupture due to celiac artery trunk compression caused by the median arcuate ligament. When clinicians see visceral aneurysms, the possibility of arcuate midline ligament compression syndrome (MALS) and ligamentectomy for MALS should be considered.
Shape‐Persistent Tetrahedral [4+6] Boronic Ester Cages with Different Degrees of Fluoride Substitution
Authors: Elbert Sven M. , Regenauer Nicolas I. , Schindler Dorothee , Zhang Wen‐Shan , Rominger Frank , Schröder Rasmus R. , Mastalerz Michael 
Published: June 2018

AbstractIn recent years the interest of shape‐persistent organic cage compounds synthesized by dynamic covalent chemistry (DCC) has risen, because these cages are potentially interesting for gas sorption or ‐separation. One such reaction in DCC is the condensation of boronic acids with diols to form boronic esters. Most interestingly, the variety of geometries and sizes for boronic ester cages is much lower than that of, for example, imine‐based cages. Here, a small series of shape‐persistent [4+6] tetrahedral boronic ester cages is introduced. One cage has a high specific surface area of 511 m2 g−1 and selectively adsorbs ethane over ethylene and acetylene.
Pd‐Catalyzed Vinylation of Aryl Halides with Inexpensive Organosilicon Reagents Under Mild Conditions
Authors: Yang Chu‐Ting , Han Jun , Liu Jun , Li Yi , Zhang Fan , Yu Hai‐Zhu , Hu Sheng , Wang Xiaolin 
Published: June 2018

AbstractPd‐catalyzed Hiyama vinylation reaction of non‐activated aryl chlorides and bromides under mild conditions was developed. The use of efficient vinyl donors and electron‐rich sterically hindered phosphine ligands was critical for the success of the reaction. The products of this transformation can be used for Am/Cm separation, an important challenge in nuclear fuel reprocessing. The substituent effect on Am/Cm separating selectivity was also achieved, which could contribute to the development of new chromatographic materials for the separation of Am and Cm.
Implementation of depth‐based routing and its enhancement in AquaSim–Next Generation for underwater wireless sensor networks
Authors: Jafri Mohsin , Balsamo Simonetta , Marin Andrea , Martin Robert 
Published: June 2018

SummaryIn the last decade, underwater wireless sensor networks have been widely studied because of their peculiar aspects that distinguish them from common terrestrial wireless networks. Their applications range from environmental monitoring to military defense. The definition of efficient routing protocols in underwater sensor networks is a challenging topic of research because of the intrinsic characteristics of these networks, such as the need of handling the node mobility and the difficulty in balancing the energy consumed by the nodes. Depth‐based routing protocol is an opportunistic routing protocol for underwater sensor networks, which provides good performance both under high and low node mobility scenarios. The main contribution of our work is presenting a novel simulator for studying depth‐based routing protocol and its variants as well as novel routing protocols. Our simulator is based on AquaSim–Next Generation, which is a specialized tool for studying underwater networks. With our work, we improve the state of the art of underwater routing protocol simulators by implementing, among other features, a detailed cross‐layer communication and an accurate model of the operational modes of acoustic modem and their energy consumption. The simulator is open source and freely downloadable. Moreover, we propose a novel and completely distributed routing protocol, named residual energy–depth‐based routing. It takes into account the residual energy at the nodes' batteries to select the forwarder nodes and improve the network lifetime by providing a more uniform energy consumption among them. We compare its performance with that of depth‐based routing protocol and a receiver‐based routing protocol implementing a probabilistic opportunistic forwarding scheme.
Geochronological, geochemical, and Nd–Hf isotopic constraints on the origin of magmatism in the Dabaoshan ore district of South China
Authors: Lei Wang , Xinbiao Jin , Deming Xu , Jinhui Cai , Yaowu Wang 
Published: June 2018

SHRIMP and LA–ICP–MS zircon U–Pb dating, Nd and Hf isotope analyses, 40Ar/39Ar geochronology, and whole‐rock geochemistry indicate three episodes of magmatism in the Dabaoshan ore district, South China: (1) Caledonian dacites (ca. 438 Ma); (2) Indosinian dolerites (ca. 210 Ma); and (3) Yanshanian granodiorites/porphyries (ca. 165 Ma) and basalts (ca. 147 Ma). Episode 1 dacites and episode 3 granodiorites/porphyries are enriched in Rb, Th, U, and LREEs and depleted in Nb, Ta, Sr, P, and Ti. The dacites may have been derived from partial melting of Mesoproterozoic–Paleoproterozoic crustal material, whereas the granodiorites/porphyries were derived mainly from partial melting of a late Mesoproterozoic crustal source with minor inputs of mantle material, according to whole‐rock εNd(t) and zircon εHf(t) values. The geochemical characteristics of episode 2 dolerites and episode 3 basalts, as well as their positive εNd(t) values (3.3–5.9 and 3.5–4.0, respectively), suggest a depleted mantle source. Taking into account the tectonic evolution of the South China Block, we suggest episode 1 dacites and episode 2 dolerites formed in an extensional setting that resulted from lithospheric delamination during the Caledonian intraplate orogeny and orogenic collapse during the Indosinian intraplate orogeny. Episode 3 granodiorites/porphyries and basalts formed in a back‐arc extensional setting in response to the westwards subduction of the Palaeo‐Pacific Plate beneath the South China Block. The timing of the three episodes of magmatism coincides roughly with the published ages of mineralization in the Dabaoshan ore district, suggesting a genetic relationship.
Control on rheological behavior of collagen 1 dispersions for efficient electrospinning
Authors: Tenchurin Timur Kh. , Belousov Sergey I. , Kiryukhin Yury I. , Istranov Leonid P. , Istranova Elena V. , Shepelev Alexey D. , Mamagulashvili Vissarion G. , Kamyshinsky Roman A. , Chvalun Sergei N. 
Published: June 2018

AbstractFor efficient manufacturing of fibrous collagen‐based materials by electrospinning, the search on optimal rheological parameters is of the great importance. Rheological characteristics and denaturation of collagen in aqueous dispersions were studied as a function of shear rate and acetic acid concentration in the range of 3–9% w/w at temperature from 20 to 40°C. It was shown that an increase in temperature, acetic acid concentration of the collagen dispersion leads to a significant decrease in its viscosity. It was found that helical conformation of the collagen macromolecules is preserved up to 31°C. An increase in acetic acid concentration leads to a reduction of denaturation temperature. The complex viscosity of collagen dispersions exhibits a sharp drop, followed by a rapid growth of damping factor in the temperature range from 22 to 35°C. Both storage (G′) and loss (G″) moduli increase with frequency and collagen concentration. It was revealed that optimal parameters for electrospinning of highly concentrated collagen dispersions can be achieved by adjusting of the concentration of acetic acid, temperature, and stirring speed. As a result, collagen nonwoven materials with diameter from 100 to 700 nm were obtained. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 107A: 312–318, 2019.
Fibrinogen adsorption to biomaterials
Authors: Horbett Thomas A. 
Published: June 2018

AbstractFibrinogen (Fg) adsorption is an important mechanism underlying cell adhesion to biomaterials and was the major focus of the author's research career. This article summarizes our work on Fg adsorption, with citations of related work as appropriate. The molecular properties of Fg that promote adsorption and cell adhesion will be described. In addition, the adsorption behavior of Fg from buffer, binary solutions with other proteins, and blood plasma will be discussed, including the Vroman effect. Studies of platelet adhesion to surfaces preadsorbed with blood plasmas selectively deficient in Fg, vitronectin (Vn), fibronectin (Fn), or von Willebrand's factor (vWf) will be reviewed. These studies clearly showed a major role for Fg in platelet adhesion under static conditions and both Fg and vWf for adhesion from flowing suspensions, but no significant role for Vn or Fn. However, it was also shown that platelet adhesion was poorly correlated with the total amount of adsorbed Fg, but very well correlated with the binding of antibodies specific to the cell binding domains of Fg. A brief overview of nonfouling surfaces for prevention of Fg adsorption will be given. A more extensive discussion of structural changes in Fg after its adsorption is included, including changes detected with both physicochemical and biological methods. A short discussion of the state of the art of structural determination of adsorbed proteins with computational methods is also given. A final section identifies Fg adsorption as the single most important event determining the biocompatibility of implants in soft tissue and in blood. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 106A: 2777–2788, 2018.