bluuebunny/crossref_metadata_2025_split huggingface dataset:
Peri‐implant soft tissue status and crestal bone levels around adjacent implants placed in cigarette smokers and never smokers: Five‐year follow‐up results
Authors: ArRejaie Aws S. , Al‐Aali Khulud Abdulrahman , Alrabiah Mohammed , Mokeem Sameer A. , Vohra Fahim , Abduljabbar Tariq 
Published: October 2018

AbstractBackgroundIt is hypothesized that peri‐implant soft tissue inflammation and crestal bone loss (CBL) are higher around adjacent implants placed in cigarette smokers compared with never smokers. The aim of the present 5‐years follow‐up retrospective clinical study was to compare the peri‐implant soft tissue status and CBL around adjacent implants placed in cigarette smokers and never smokers.MethodsCigarette smokers (group 1) and never smokers (group 2) with adjacent dental implants were included. Demographic information regarding age, sex, duration of smoking (pack‐years), daily frequency of toothbrushing and most recent visit to a dentist or dental hygienist were recorded using a questionnaire. Information regarding implant dimensions (length × diameter), duration of implants in function, loading protocol (and type of restoration was recorded. Peri‐implant plaque index (PI), bleeding on probing (BOP), probing depth (PD), and mesial and distal CBL were measured. P <0.05 were considered statistically significant.ResultsSeventy‐two male participants (37 in group 1 and 35 in group 2) were included. The mean age of individuals in groups 1 and 2 were 50.3 ± 5.4 and 48.5 ± 3.8 years, respectively. In group 1, the mean duration of cigarette smoking was 22.3 ± 1.6 pack years. A family history of smoking was more often reported by individuals in group 1 compared with group 2. In groups 1 and 2, 54 and 70 adjacent implants, respectively were placed in the regions of missing premolars and molars. All implants were delayed loaded and were fixed with non‐splinted screw‐retained restorations. In groups 1 and 2, toothbrushing twice daily was reported by 78.3% and 74.2% individuals, respectively. There was no statistically significant difference in peri‐implant PI, BOP, PD, and mesial and distal CBL among individuals in groups 1 and 2.ConclusionPeri‐implant soft tissue status and crestal bone levels were comparable around adjacent dental implants placed in cigarette smokers and never smokers.
Titanium particles generated during ultrasonic scaling of implants
Authors: Harrel Stephen K. , Wilson Thomas G. , Pandya Mirali , Diekwisch Thomas G. H. 
Published: October 2018

AbstractBackgroundThere is growing concern that titanium particles may play a role in peri‐implant breakdown. Ultrasonic scalers are routinely used in the debridement of peri‐implant lesions. This in vitro study is designed to evaluate if titanium particles are produced when an ultrasonic scaler is used on an implant.MethodsNew sandblasted, large grit, acid etched (SLA) coated implants were subjected to ultrasonic scaling with stainless steel, titanium, and PEEK plastic tips. The implants were placed in a holding device and the ultrasonic scaler was positioned on the SLA surface under 25 grams of pressure. The implants were subjected to 30 scaling motions. The ultrasonic coolant water was collected and the number of metallic particles were counted under a light microscope. The particles were confirmed to be titanium via elemental analysis. The implants were visually evaluated for damage to the SLA coating.ResultsNo metallic particles were detected in the water supplied to the ultrasonic scalers (passive control). Metallic particles were detected when implants were subjected to the ultrasonic coolant water only without the scaler tip touching the implant (active control). All implants that were scaled produced metallic particles and showed easily detectable damage to the SLA layer.ConclusionsAll ultrasonic scaling caused the production of titanium particles and caused damage to the SLA coating of the implant. Ultrasonic scalers should be used with great caution in the treatment of peri‐implant conditions and care should be taken to not touch the SLA surface of the implant.
Surface‐enhanced resonance Raman scattering for the sensitive detection of a tuberculosis biomarker in human serum
Authors: Owens Nicholas A. , Pinter Abraham , Porter Marc D. 
Published: October 2018

AbstractImprovements in the detection of biomarkers indicative of disease continue to be vital to human health. Toward this end, this paper presents (a) the development and characterization of a biomarker detection strategy based on the inherently stronger signals generated by surface‐enhanced resonance Raman scattering (SERRS), as opposed to surface‐enhanced Raman scattering (SERS); (b) the application of this approach to the detection of mannose‐capped lipoarabinomannan (ManLAM), an antigenic marker indicative of active tuberculosis infection; and (c) a comparison of readout for this SERRS platform to that of the more frequently used approach based on SERS. More specifically, the work detailed herein describes the design and testing of a SERRS immunoassay that incorporates a resonance Raman‐enhanced adlayer of cyanine 5 on a smooth gold capture surface and its application to biomarker detection when “turned on” by the tagging of captured ManLAM with gold nanoparticle labels. The results of these experiments demonstrated an improvement in the detection of ManLAM spiked into human serum in terms of limit of detection by 10× and analytical sensitivity of almost 40× when compared with SERS. Findings also indicate that these improvements arise primarily from the intrinsic increase in signal strength due to the resonance Raman effect and a small but measurable increase in nanoparticle label density. Potential routes to further improve the performance of this approach to immunoassay signal generation are briefly discussed.
Integrated spatial assessment of inland excess water hazard on the Great Hungarian Plain
Authors: Bozán Csaba , Takács Katalin , Körösparti János , Laborczi Annamária , Túri Norbert , Pásztor László 
Published: October 2018

AbstractInland excess water (IEW) is a form of surplus surface water, often regarded as a specific flood type. However, it occurs most frequently in local depressions of large flat areas, irrespective of river floods and the surface water networks. IEW is considered to be a typical Carpathian Basin problem, as it can cause major land degradation problems in the agricultural areas of Hungary, mainly located on the Great Hungarian Plain (GHP). An innovative method for mapping the probability of IEW inundation is proposed in this study. This method is based on the geostatistical modelling of the relationship between the natural and human driving factors and the occurrence of IEW inundations. The results show that significant part of the GHP (about 500,000 hectares) is moderately or highly affected by IEW inundations, where the combination of multiple influencing factors simultaneously occur. The resulted IEW inundation probability map can be used to meet future challenges in agricultural management and the adaptations to climate change effects.
Universal quadratic forms and indecomposables over biquadratic fields
Authors: Čech Martin , Lachman Dominik , Svoboda Josef , Tinková Magdaléna , Zemková Kristýna 
Published: October 2018

AbstractThe aim of this article is to study (additively) indecomposable algebraic integers of biquadratic number fields K and universal totally positive quadratic forms with coefficients in . There are given sufficient conditions for an indecomposable element of a quadratic subfield to remain indecomposable in the biquadratic number field K. Furthermore, estimates are proven which enable algorithmization of the method of escalation over K. These are used to prove, over two particular biquadratic number fields and , a lower bound on the number of variables of a universal quadratic forms.
Genotypic and phenotypic characterization of Escherichia coli isolated from mollusks in Brazil and the United States
Authors: Miotto Marília , Ossai Sylvia A. , Meredith Joan E. , Barretta Clarissa , Kist Airton , Prudencio Elane S. , R. W. Vieira Cleide , Parveen Salina 
Published: October 2018

AbstractThe aim of this study was to determine the serogroups, antimicrobial resistance and genetic diversity of Escherichia coli isolates from samples of bivalve mollusks collected along Santa Catarina coast, Brazil, and from the Chesapeake Bay, Maryland, USA. One hundred forty‐one E. coli isolates were characterized for serogroups with 181 specific O antisera and antimicrobial susceptibility using the disk diffusion method. The genetic diversity was assessed using pulsed‐field gel electrophoresis (PFGE). The results showed that among the isolates, 19.9% were classified as multi‐drug resistant (MDR) and resistance was most frequently observed to cephalothin, nitrofurantoin, and ampicillin. The predominant serogroups were O6, O8, and O38. Some serogroups were recognized as pathogenic E. coli. PFGE dendrograms indicated extensive genetic diversity among the isolates. Although characteristics of the E. coli isolates were highly variable, it is important to note that E. coli belonging to pathogenic serogroups and MDR isolates are present in mollusks of both study areas. This is the first report on the phenotypic and genotypic characterization of E. coli from mollusks from Santa Catarina and the Chesapeake Bay that should encourage studies focusing on comparison of isolates across countries.
A new strategy for seamless gene editing and marker recycling in Saccharomyces cerevisiae using lethal effect of Cwp1
Authors: Hu Yuxiao , Jia Yanrong , Zhao Xiangdong , Yang Zihao , Hao Zhimin , Dong Jingao , Zeng Fanli 
Published: October 2018

AbstractTechnologies development for seamless gene editing and marker recycling has allowed frequent genomic engineering in Saccharomyces cerevisiae for desired laboratory strains and cell factory. Alternative new approaches are still required for complicated scenarios. In this study, we report that inducible overexpression of cell wall protein 1 (Cwp1) by galactose addition confers yeast cells a robust growth inhibition. Direct repeats flanking the Gal‐CWP1:selectable marker cassette allow for its homology recombination excision and counter selection upon galactose addition, therefore enable seamless gene editing and marker recycling. We used this strategy and efficiently generated scarless Ade8 deletion mutants. Our results highlight the utility of lethal effect of Cwp1 overexpression a new counter selection strategy and a simple and efficient method for seamless gene editing and marker recycling in S. cerevisiae and potentially other fungi.
Oculo‐visual abnormalities in Parkinson's disease: Possible value as biomarkers
Authors: Guo Li , Normando Eduardo M. , Shah Parth Arvind , De Groef Lies , Cordeiro M. Francesca 
Published: October 2018

ABSTRACTParkinson's disease (PD) is one of the most common neurodegenerative disorders and the second leading cause of dementia worldwide. With an aging population, the prevalence of the disease has dramatically increased. Clinical management has advanced through recent developments in dopaminergic imaging and genetic risk profiling. However, early and accurate diagnosis of the disorder remains a challenge, largely because of the lack of noninvasive and inexpensive reliable diagnostic tests. Besides the well‐studied cerebral neurodegeneration that underlies the cardinal symptoms of PD (ie, bradykinesia, tremor, rigidity, and postural instability), ocular changes have also been described in PD, including visual dysfunction, pupil abnormality, lens opacity, and retinal neuronal loss and dysfunction. These ocular pathological processes are related to α‐synuclein deposition, and dopamine deficiency in the retina—mirroring the defining pathological features of PD in the brain. Together, these observations support the notion that the eye can serve as a window to the brain, providing clinicians with noninvasive methods to visualize disease. This review focuses on recent advances in the characterization of ocular changes in PD and their promising use as biomarkers in the eye, which can be potentially used for aiding in early diagnosis, tracking disease progression, and valuating novel therapeutic strategies. © 2018 International Parkinson and Movement Disorder Society
A dual‐mode waveguide filter based on stereometamaterial CSRR resonator
Authors: Bod Mohammad , Hatefi Ardakani Hossein 
Published: October 2018

AbstractThis paper represents a new dual‐mode waveguide filter based on a stereometamaterial resonator. A novel resonator is proposed in the paper consisting of two stacked complementary split ring resonators (CSRR) where one of them is twisted in its plane. This resonator provides a transmission zero, which can be easily adjusted in both of the upper and lower stopbands of the filter. By cascading the four of the proposed resonator, an eight order symmetric filter with four transmission zeros are designed. The filter parameters are optimized using the genetic algorithm (GA). This filter is fabricated and the experimental results are in a good agreement with the simulation data. Besides the flexibility in the design, the most important characteristic of the proposed structure is its compactness compared to similar structures.
Whole‐heart spiral simultaneous multi‐slice first‐pass myocardial perfusion imaging
Authors: Yang Yang , Meyer Craig H. , Epstein Frederick H. , Kramer Christopher M. , Salerno Michael 
Published: October 2018

PurposeTo develop and evaluate a simultaneous multislice (SMS) spiral perfusion pulse sequence with whole‐heart coverage.MethodsAn orthogonal set of phase cycling angles following a Hadamard pattern was incorporated into a golden‐angle (GA) variable density spiral perfusion sequence to perform SMS imaging at different multiband (MB) factors. Images were reconstructed using an SMS extension of L1‐SPIRiT that we have termed SMS‐L1‐SPIRiT. The proposed sequence was evaluated in 40 subjects (10 each for MB factors of 1, 2, 3, and 4). Images were blindly graded by 2 cardiologists on a 5‐point scale (5, excellent). To quantitatively evaluate the reconstruction performance against images acquired without SMS, the MB =1 data were used to retrospectively simulate data acquired at MB factors of 2 to 4.ResultsAnalysis of the SMS point‐spread function for the desired slice showed that the proposed sampling strategy significantly canceled the main‐lobe energy of the other slices and has low side‐lobe energy resulting in an incoherent temporal aliasing pattern when rotated by the GA. Retrospective experiments demonstrated the SMS‐L1‐SPIRiT method removed aliasing from the interfering slices and showed excellent agreement with the ground‐truth MB =1 images. Clinical evaluation demonstrated high‐quality perfusion images with average image‐quality scores of 4.3 ± 0.5 (MB =2), 4.2 ± 0.5 (MB =3), and 4.4 ± 0.4 (MB =4) with no significant quality difference in image quality between MB factors (P = 0.38).ConclusionSMS spiral perfusion at MB factors 2, 3, and 4 produces high‐quality perfusion images with whole‐heart coverage in a clinical setting with high sampling efficiency.
Pelvic floor muscle training is better than hypopressive exercises in pelvic organ prolapse treatment: An assessor‐blinded randomized controlled trial
Authors: Resende Ana Paula M. , Bernardes Bruno T , Stüpp Liliana , Oliveira Emerson , Castro Rodrigo A. , Girão Manoel J.B.C. , Sartori Marair G.F. 
Published: October 2018

AimsTo verify if hypopressive exercises (HEs) can improve pelvic organ prolapse (POP) symptoms equally or better than pelvic floor muscle training (PFMT).MethodsRandomized controlled trial. Symptomatic women with untreated stage II POP according to the Pelvic Organ Prolapse Quantification System (POP‐Q) having the ability to contract their pelvic floor muscles were invited. The outcome measures were POP symptoms as measured by specific questions and Prolapse Quality of Life (P‐QoL); POP severity as measured by POP‐Q; and PFM function. Intervention consisted by 12 weeks of PFMT or an HE home exercise program with bimonthly sessions with a physiotherapist. The protocol consisted of three initial sessions to learn how to perform the exercises correctly, followed by 3 months of exercise with monthly progression. Volunteers filled out exercise diaries to record their compliance.ResultsPFMT presented better results in terms of the following symptoms: a bulge/lump from or in the vagina, heaviness or dragging on the lower abdomen, and stress incontinence. PFMT also presented better results regarding the Prolapse impact and role, social and personal limitations of P‐QoL. Regarding the total number of symptoms at the end, the PFMT group presented a mean of 1.7 (±1.2), and the HE group presented a mean of 2.8 (±1,1); the effect size was 1.01 in favor of the PFMT group (95%CI = 1.002‐1.021).ConclusionBoth groups exhibited improvements in POP symptoms, quality of life, prolapse severity, and PFM function. PFMT was superior to HE for all outcomes.
Neurophysiologic study in idiopathic overactive bladder
Authors: Ali Rowaida H. , Gadallah Naglaa A. , El Zohiery Abeer K. , Elwy Mohamed , Serag Ihab 
Published: October 2018

AimIdiopathic overactive bladder (OAB) is a prevalent, mystifying disorder with a questionable neurogenic background. We aimed to investigate the possible subtle neuropathic affection underlying its pathogenesis.MethodsA cross‐sectional cut off study was carried out on a series of 38 females with idiopathic OAB and 22 healthy matched female volunteers. The following was performed: symptom score questionnaire, determination of pudendal nerve terminal motor latency (PNTML), sacral reflexes’ latencies, pudendal somatosensory evoked potentials, and needle electromyography of the external anal and urethral sphincters.ResultsA highly significant prolongation of PNTMLs and sacral reflexes latencies among the patients group was detected (P ≥ 0.001). Pudendal somatosensory evoked potentials showed non‐ significance among the two studied groups (P ≥ 0.05). External anal sphincter neuropathic affection was detected in 27 patients (71%) and external urethral sphincter neuropathic affection was detected in 30 patients (78.9%). The clitoral anal reflex showed the highest sensitivity and specificity among the neurophysiologic tests used in assessing the neuropathic affection (86.7 and 83%, respectively), followed by PNTML (83.3 and 80%, respectively).ConclusionPudendal neuropathy is the dominating possible attributing factor in the pathogenesis underlying idiopathic OAB. An integrated clinical, urodynamic, and electro‐physiological assessment is recommended for evaluation of any overactive bladder patients.
Uroflow measurement combined with electromyography testing of the pelvic floor in healthy children
Authors: Samijn Bieke , Van Laecke Erik , Vande Walle Johan , Pascal Aurelie , Deschepper Ellen , Renson Catherine , Van den Broeck Christine 
Published: October 2018

AimsTo investigate if the standard protocol for uroflowmetry, recommended by the International Children's Continence Society, remains accurate when integrating EMG measurement by means of superficial electrodes.MethodsA cross‐sectional study was conducted including healthy children. Group A performed two direct repetitions of uroflowmetry in combination with electromyography (uroflow/EMG). Group B performed a preceding measurement of isolated uroflowmetry, followed by two randomized measurements of uroflowmetry with and without EMG. Interpretation of uroflow curve was assessor blinded by a pediatric urologist and secondly performed using the flow index methodology. Statistical analysis compared different voids within each group and between group A and B.ResultsEighty‐three children were included and 206 uroflow measurements were obtained. In both groups statistical findings confirmed the hypothesis that it is preferable to perform an additional measurement before the use of uroflow/EMG. Although both groups showed improvement between voids, the group with initial uroflow measurement followed by uroflow/EMG measurement showed more improvement in concern of curve pattern. An initially better first void in group A, but no statistical difference between the second void in group A and uroflow/EMG testing in group B further demonstrates a higher improvement in group B. This suggests the use of a precedent uroflowmetry without EMG is preferable to immediate testing with EMG.ConclusionsIt should be mandatory to perform one measurement in advance to ensure the reliability of the results. It is suggested to initiate the procedure with a single uroflowmetry measurement followed by one measurement of uroflow with EMG testing.
Similarity of functional connectivity patterns in patients with multiple sclerosis who void spontaneously versus patients with voiding dysfunction
Authors: Khavari Rose , Elias Saba N. , Boone Timothy , Karmonik Christof 
Published: October 2018

AimTo investigate if Multiple Sclerosis (MS) lesion characteristics affect functional brain connectivity (FC) during bladder voiding.MethodsTwenty‐seven ambulatory female patients with MS completed our functional magnetic resonance imaging (fMRI)/urodynamic testing (UDS) platform. Individual fMRI activation maps were generated at initiation of voiding. FC patterns of these regions were calculated and compared. Similarity of the FC pattern from one patient relative to all others was expressed by a parameter FC_sim. A statistical analysis was performed to reveal the relationship of the existence of an enhancing brain lesion, the size of the largest lesion and the ability to void spontaneously to this FC similarity measure.ResultsFC_sim values were significantly lower for patients with an enhancing MS lesion (11.7 ± 3.1 vs 5.3 ± 2.1 P < 0.001). Lesion size smaller than 20 mm inversely correlated significantly with FC_sim (R = −0.43, P = 0.05). Patients with the ability to void spontaneously had a higher FC_sim value (12.0 ± 2.8 vs 9.3 ± 4.4 s, P = 0.08). Patients that exhibited a decrease of compliance also showed a significantly lower FC_sim value (11.3 ± 3.5 vs 4.7 ± 0.7, P < 1e‐5).ConclusionFC connectivity analysis derived from an fMRI task‐based study including repetitive voiding cycles is able to quantify the heterogeneity of connectivity patterns in the brain of MS patients. FC similarity decreased with maximum lesion size or the presence of enhancing lesions affecting the ability to void spontaneously.