bluuebunny/crossref_metadata_2025_split huggingface dataset:
Unusual late July observation of a fledgling Lapland longspur in low Arctic Greenland following the cool spring of 2018
Authors: Post Eric , Beyen Eva , Bøving Pernille Sporon , Higgins R. Conor , John Christian , Kerby Jeff , Pedersen Christian , Watts David A. 
Published: March 2019

We report an observation of a flightless fledgling Lapland longspur (Calcarius lapponicus (Linnaeus, 1758)) at a long-term study site near Kangerlussuaq, Greenland, in late July 2018. Based on our observations of longspur nests at the site dating back to 1993, we estimate that the fledgling observed in 2018 may have originated from a nest initiated 12–37 d later than nesting in previous years. Onset of spring in 2018 was late, but comparable with other years in which longspur nests were observed a full calendar month earlier than in 2018. An analysis including multiple candidate predictor variables revealed a strong negative association between estimated longspur nest initiation dates and mean May temperature, as well as a weaker association with the length of the annual period of vegetation green up at the site. Given the limitations of our data, however, we are unable to assign causality to the 2018 observation, and cannot rule out other possibilities, such as that it may have resulted from a second clutch.
Massive and massless scalar field models for Kaluza–Klein universe in f(R, T) gravity
Authors: Aktaş Can 
Published: March 2019

In this research, we have investigated the behavior of massive and massless scalar field (SF) models (normal and phantom) for Kaluza–Klein universe in [Formula: see text] gravity with cosmological term ([Formula: see text]). To obtain field equations, we have used [Formula: see text] model given by Harko et al. [Phys. Rev. D 84, 024020 (2011)] and anisotropy feature of the universe. Finally, we have discussed our results in [Formula: see text] and General Relativity Theory (GRT) with various graphics.
Comprehensive structural and optical characterization of AlAs/GaAs distributed Bragg reflector
Authors: Alaydin B. O. , Tuzemen E. S. , Altun D. , Elagoz S. 
Published: March 2019

30-pair AlAs/GaAs distributed Bragg reflector (DBR), which has 1030 nm center reflectivity, is studied extensively by means of High Resolution X-ray Diffraction (HR-XRD) and reflectivity measurements. Theta/2-Theta measurements and dynamical simulations have been done for (002), (004) and (006) planes to determine strain and thickness of AlAs and GaAs layers in the DBR stack. Reciprocal space mappings (RSMs) are measured for same planes and also for (224) plane to find out tilt and relaxation of the DBR stack. Relaxation is not observed and it is confirmed with symmetric in-plane (400) Theta/2-Theta and RSM measurements. This is a first study in the literature according to the best of our knowledge. Finally, we have shown sensitivity of high angle diffraction planes to disorders in crystal. Angle-dependent reflectivity simulations have been also done and compared with measurements. 99.99% reflectivity is obtained with 99.5 nm stop bandwidth and 482.7 nm penetration depth.
Susceptibility Perturbation MRI Maps Tumor Infiltration into Mesorectal Lymph Nodes
Authors: Santiago Inês , Santinha João , Ianus Andrada , Galzerano Antonio , Theias Rita , Maia Joana , Barata Maria J. , Loução Nuno , Costa-Silva Bruno , Beltran Antonio , Matos Celso , Shemesh Noam 
Published: March 2019

Abstract

Noninvasive characterization of lymph node involvement in cancer is an enduring onerous challenge. In rectal cancer, pathologic lymph node status constitutes the most important determinant of local recurrence and overall survival, and patients with involved lymph nodes may benefit from preoperative chemo and/or radiotherapy. However, knowledge of lymph node status before surgery is currently hampered by limited imaging accuracy. Here, we introduce Susceptibility-Perturbation MRI (SPI) as a novel source of contrast to map malignant infiltration into mesorectal lymph nodes. SPI involves multigradient echo (MGE) signal decays presenting a nonmonoexponential nature, which we show is sensitive to the underlying microstructure via susceptibility perturbations. Using numerical simulations, we predicted that the large cell morphology and the high cellularity of tumor within affected mesorectal lymph nodes would induce signature SPI decays. We validated this prediction in mesorectal lymph nodes excised from total mesorectal excision specimens of patients with rectal cancer using ultrahigh field (16.4 T) MRI. SPI signals distinguished benign from malignant nodal tissue, both qualitatively and quantitatively, and our histologic analyses confirmed cellularity and cell size were the likely underlying sources for the differences observed. SPI was then adapted to a clinical 1.5 T scanner, added to patients' staging protocol, and compared with conventional assessment by two expert radiologists. Nonmonoexponential decays, similar to those observed in the ex vivo study, were demonstrated, and SPI classified lymph nodes more accurately than standard high-resolution T2-weighted imaging assessment. These findings suggest this simple, yet highly informative, method can improve rectal cancer patient selection for neoadjuvant therapy.

Significance:
These findings introduce an MRI methodology tailored to detect magnetic susceptibility perturbations induced by subtle alterations in tissue microstructure.
Epigenomic Reordering Induced by Polycomb Loss Drives Oncogenesis but Leads to Therapeutic Vulnerabilities in Malignant Peripheral Nerve Sheath Tumors
Authors: Wojcik John B. , Marchione Dylan M. , Sidoli Simone , Djedid Anissa , Lisby Amanda , Majewski Jacek , Garcia Benjamin A. 
Published: March 2019

Abstract

Malignant peripheral nerve sheath tumor (MPNST) is an aggressive sarcoma with recurrent loss-of-function alterations in polycomb-repressive complex 2 (PRC2), a histone-modifying complex involved in transcriptional silencing. To understand the role of PRC2 loss in pathogenesis and identify therapeutic targets, we conducted parallel global epigenomic and proteomic analysis of archival formalin-fixed, paraffin-embedded (FFPE) human MPNST with and without PRC2 loss (MPNSTLOSS vs. MPNSTRET). Loss of PRC2 resulted in increased histone posttranslational modifications (PTM) associated with active transcription, most notably H3K27Ac and H3K36me2, whereas repressive H3K27 di- and trimethylation (H3K27me2/3) marks were globally lost without a compensatory gain in other repressive PTMs. Instead, DNA methylation globally increased in MPNSTLOSS. Epigenomic changes were associated with upregulation of proteins in growth pathways and reduction in IFN signaling and antigen presentation, suggesting a role for epigenomic changes in tumor progression and immune evasion, respectively. These changes also resulted in therapeutic vulnerabilities. Knockdown of NSD2, the methyltransferase responsible for H3K36me2, restored MHC expression and induced interferon pathway expression in a manner similar to PRC2 restoration. MPNSTLOSS were also highly sensitive to DNA methyltransferase and histone deacetylase (HDAC) inhibitors. Overall, these data suggest that global loss of PRC2-mediated repression renders MPNST differentially dependent on DNA methylation to maintain transcriptional integrity and makes them susceptible to therapeutics that promote aberrant transcription initiation.

Significance:
Global profiling of histone PTMs and protein expression in archival human MPNST illustrates how PRC2 loss promotes oncogenesis but renders tumors vulnerable to pharmacologic modulation of transcription.
See related commentary by Natarajan and Venneti, p. 3172
A Clinical Score to Predict Severe Acute Kidney Injury in Chinese Patients after Cardiac Surgery
Authors: Che Miaolin , Wang Xudong , Liu Shang , Xie Bo , Xue Song , Yan Yucheng , Zhu Mingli , Lu Renhua , Qian Jiaqi , Ni Zhaohui , Zhang Weiming , Wang Bingshun 
Published: March 2019

<b><i>Background/Aims:</i></b> Cardiac surgery-associated severe acute kidney injury (SAKI) is associated with high mortality and poor quality of life. A prognostic score for SAKI may enable prevention of complications. Methods: This observational study of 2,552 patients undergoing cardiac surgery from January 2006 to December 2011 in our institution established associations between predictor variables and postoperative SAKI from a cohort of 1,692 patients and developed a clinical score that was assessed in a validation cohort of 860 patients. <b><i>Results:</i></b> Postoperative SAKI occurred in 262 ­patients (10.3%). We identified 7 independent and significant risk factors in the derivation model (adjusted OR 95% CI): age ≥81 years (vs. age &#x3c; 40 years, 4.30, 1.52–12.21), age 61–80 years (vs. age &#x3c; 40 years, 2.84, 1.24–6.52), age 41–60 years (vs. age &#x3c; 40 years, 1.62, 0.68–3.87), hypertension (1.65, 1.13–2.39), previous cardiac surgery (3.62, 1.27–10.32), ­hyperuricemia (2.02, 1.40–2.92), prolonged operation time (1.32, 1.17–1.48), postoperative central venous pressure &#x3c; 6 mm H<sub>2</sub>O (3.53, 2.38–5.23), and low postoperative cardiac output (4.78, 2.97–7.69). The 7-variable risk prediction model had acceptable performance characteristics in the validation cohort (C statistic 0.80, 95% CI 0.74–0.85). The difference in the C statistic was 0.21 (95% CI 0.12–0.29, <i>p</i> &#x3c; 0.001) compared with the Cleveland Clinic score. <b><i>Conclusion:</i></b> We developed and validated a practical risk prediction model for SAKI after cardiac surgery based on routinely available perioperative clinical and laboratory data. The prediction model can be easily applied at the bedside and provides a simple and interpretable estimation of risk.
Merged Cloud and Precipitation Dataset from the HIAPER GV for the Cloud System Evolution in the Trades (CSET) Campaign
Authors: Schwartz M. Christian , Ghate Virendra P. , Albrecht Bruce. A. , Zuidema Paquita , Cadeddu Maria P. , Vivekanandan Jothiram , Ellis Scott M. , Tsai Pei , Eloranta Edwin W. , Mohrmann Johannes , Wood Robert , Bretherton Christopher S. 
Published: March 2019

AbstractThe Cloud System Evolution in the Trades (CSET) aircraft campaign was conducted in the summer of 2015 in the northeast Pacific to observe the transition from stratocumulus to cumulus cloud regime. Fourteen transects were made between Sacramento, California, and Kona, Hawaii, using the NCAR’s High-Performance Instrumented Airborne Platform for Environmental Research (HIAPER) Gulfstream V (GV) aircraft. The HIAPER W-band Doppler cloud radar (HCR) and the high-spectral-resolution lidar (HSRL), in their first deployment together on board the GV, provided crucial cloud and precipitation observations. The HCR recorded the raw in-phase (I) and quadrature (Q) components of the digitized signal, from which the Doppler spectra and its first three moments were calculated. HCR/HSRL data were merged to develop a hydrometeor mask on a uniform georeferenced grid of 2-Hz temporal and 20-m vertical resolutions. The hydrometeors are classified as cloud or precipitation using a simple fuzzy logic technique based on the HCR mean Doppler velocity, HSRL backscatter, and the ratio of HCR reflectivity to HSRL backscatter. This is primarily applied during zenith-pointing conditions under which the lidar can detect the cloud base and the radar is more sensitive to clouds. The microphysical properties of below-cloud drizzle and optically thin clouds were retrieved using the HCR reflectivity, HSRL backscatter, and the HCR Doppler spectrum width after it is corrected for the aircraft speed. These indicate that as the boundary layers deepen and cloud-top heights increase toward the equator, both the cloud and rain fractions decrease.
A Supraglottic Mass in a Pediatric Patient: An Unusual Presentation of Lymphoma
Authors: Perez Paloma Irizarry , McIlwain Wesley , Winters James , Dhesi Mary , Rogers Derek J. 
Published: March 2019

Objective: To present a case of laryngeal lymphoma in a pediatric patient and perform a literature review of this rare entity. Patient: A 13-year-old male presented with a rapidly enlarging right neck mass. Work-up of the neck mass included a computed tomography scan of the neck with contrast and revealed a 2.5 cm right level II neck mass and an asymmetric lobulated soft tissue mass in the right pyriform sinus. Intervention: The patient underwent excisional biopsy of the right supraglottic mass. Once his diagnosis was confirmed, he was treated with a standard lymphoma protocol. Results: Intraoperative frozen analysis revealed a small blue cell tumor. Final pathology demonstrated diffuse large B-cell lymphoma of the germinal center B-cell subtype (GC-DLBCL). The patient underwent treatment with primary chemotherapy 12 days after his original procedure with cyclophosphamide, doxorubicin, vincristine, and prednisone. Conclusion: Laryngeal lymphoma remains extremely rare in the pediatric population. With appropriate treatment, the 5-year disease-free survival remains excellent for germinal center diffuse large B-cell lymphoma.
Recurrent and Progressive Facial Baroparesis on Flying Relieved by Eustachian Tube Dilation
Authors: Cheng Tracy Z. , Kaylie David M. 
Published: March 2019

Objectives: Facial baroparesis is a rare phenomenon of seventh cranial nerve palsy traditionally reported in divers, with only 11 cases reported in aviation so far. It is important to correctly diagnose facial baroparesis given the differential diagnosis of stroke and decompression disease and offer appropriate treatment for recurrent cases. Methods: The authors present the case of a patient with recurrent and progressive facial baroparesis treated with Eustachian tube balloon dilation. Institutional medical records were reviewed, and analysis of the current literature was performed. Results: A 37-year-old woman experienced recurrent and progressive left facial paralysis on descent from altitude on commercial airline flights, with resolution between flights. The patient flew frequently for work-related trips and for the past 7 years had noted facial paralysis that began with mild asymmetry of the face and progressed to an inability to close her left eye. She denied any otologic symptoms other than ear fullness and pressure causing left otalgia. The right side was not involved. After treatment with Eustachian tube dilation, the patient has been on numerous flights with complete resolution of symptoms. Conclusions: This study presents a rare case of facial baroparesis on commercial flight descent that resolved after left Eustachian tube dilation. Although unilateral facial palsy can be concerning for stroke, a history of ear fullness and pressure may suggest facial baroparesis instead. For recurrent and progressive cases, Eustachian tube dilation should be considered for treatment.
Variations in Blood Supply From Proximal to Distal in the Ulnar Collateral Ligament of the Elbow: A Qualitative Descriptive Cadaveric Study
Authors: Buckley Patrick S. , Morris Elizabeth R. , Robbins Colin M. , Kemler Bryson R. , Frangiamore Salvatore J. , Ciccotti Michael G. , Huard Johnny , LaPrade Robert F. , Hackett Thomas R. 
Published: March 2019

Background: The vascular supply of the ulnar collateral ligament (UCL) is unknown. Previous studies reported varying success in return-to-play rates after nonoperative management of partial UCL tears and suggested a varying healing capacity as possibly related to the location of the UCL injury. Purpose: To analyze the macroscopic vascular anatomy of the UCL of the elbow. Study Design: Descriptive laboratory study. Methods: Eighteen fresh-frozen male cadaveric elbows from 9 donors were sharply dissected 15 cm proximal to the medial epicondyle. Sixty milliliters of India ink was injected through the brachial artery of each elbow. Arms were then frozen at −10°C, radial side down, in 15° to 20° of elbow flexion. A band saw was used to section the frozen elbows into 5-mm coronal or sagittal sections. Sections were cleared for visualization with the modified Spalteholz technique. Images of the specimens were taken, and qualitative description of UCL vascularity was undertaken. Results: The authors consistently found a dense blood supply to the proximal UCL, while the distal UCL was hypovascular. They also observed a possible osseous contribution to the proximal UCL from the medial epicondyle in addition to an artery from the flexor/pronator musculature that consistently appeared to provide vascularity to the proximal UCL. The degree of vascular penetration from proximal to distal in the UCL ranged from 39% to 68% of the overall UCL length, with a 49% mean length of vascular penetration of the UCL. Conclusion: This study found a difference in the vascular supply of the UCL. The proximal UCL was well vascularized, while the distal UCL was hypovascular. This difference in vascular supply may be a factor in the differential healing capacities of the UCL based on the location of injury. Clinical Relevance: An improved understanding of the macroscopic vascular supply of the UCL may aid in the clinical management of partial UCL tears and suggests an indication for these treatments with respect to location of UCL injuries.
Safety and Putative Benefits of Tracheostomy Tube Placement in Patients on Extracorporeal Membrane Oxygenation: A Single-Center Experience
Authors: Grewal Jatinder , Sutt Anna-Liisa , Cornmell George , Shekar Kiran , Fraser John 
Published: March 2019

Purpose: Patients supported with extracorporeal membrane oxygenation (ECMO) have been reported to have increased sedation requirements. Tracheostomies are performed in intensive care to facilitate longer term mechanical ventilation, reduce sedation, improve patient comfort, secretion clearance, and ability to speak and swallow. We aimed to investigate the safety of tracheostomy (TT) placement on ECMO, its impact on fluid intake, and the use of sedative, analgesic, and vasoactive drugs. Methods: Prospective data were collated for all ECMO patients over a 5.5-year period. Data included the cumulative dose of sedatives and analgesics, fluid balance, inotrope and vasopressor requirements, and number of packed red cell (PRC) units transfused. Data were analyzed to determine the differences in the aforementioned between 5 days pre-TT and post-TT insertion. Results: Thirty-one (22.1%) of 140 patients underwent TT while on ECMO in the study period. Inotrope and vasopressor use was significantly less in the post-TT period compared to pre-TT dose ( P value = .01). This was in the setting of Sequential Organ Failure Assessment scores the day before TT placement being significantly greater than those on days 2, 3, and 4. There was a trend toward reduction in analgesic usage in the post-TT period. No major complications of TT were reported. There was no significant difference ( P value = .46) in the amount of PRC used post-TT. Conclusions: These data indicate that TT may result in a reduction in vasopressor and inotropic requirement. Data do not suggest increased major bleeding with placement of TT in patients on ECMO. The potential risk and benefits of inserting a TT in ECMO patients need further validation in prospective clinical studies.
Supporting informed choice in acupuncture: effects of a new person-, evidence- and theory-based website for patients with back pain
Authors: Bishop Felicity L , Greville-Harris Maddy , Bostock Jennifer , Din Amy , Graham Cynthia A , Lewith George , Liossi Christina , O’Riordan Tim , White Peter , Yardley Lucy 
Published: March 2019

Objectives: To test whether a newly developed person-, theory- and evidence-based website about acupuncture helps patients make informed decisions about whether or not to use acupuncture for back pain. Methods: A randomised online study compared a newly developed ‘enhanced website’ to a ‘standard website’. The enhanced website provided evidence-based information in a person-based manner and targeted psychological constructs. The standard website was based on a widely used patient information leaflet. In total, 350 adults with recent self-reported back pain were recruited from general practices in South West England. The two primary outcomes were knowledge change and making an informed choice about using acupuncture. Secondary outcomes were beliefs about and willingness to have acupuncture. Results: Participants who viewed the enhanced acupuncture website had a significantly greater increase in knowledge about acupuncture (M = 1.1, standard deviation (SD) = 1.7) than participants who viewed the standard website (M = 0.2, SD = 1.1; F(1, 315) = 37.93, p < 0.001, η2 = .107). Participants who viewed the enhanced acupuncture website were also 3.3 times more likely to make an informed choice about using acupuncture than those who viewed the standard website (χ2(1) = 23.46, p < 0.001). There were no significant effects on treatment beliefs or willingness to have acupuncture. Conclusion: The enhanced website improved patients’ knowledge and ability to make an informed choice about acupuncture, but did not optimise treatment beliefs or change willingness to have acupuncture. The enhanced website could be used to support informed decision-making among primary care patients and members of the general public considering using acupuncture for back pain.
Do Doppler Changes Reflect Pathology of Placental Vascular Lesions in IUGR Pregnancies?
Authors: Ravikumar Gayatri , Crasta Julian 
Published: March 2019

Objectives Doppler assessment of uteroplacental (UP) and fetoplacental (FP) circulation detects abnormal waveforms in intrauterine growth-restricted (IUGR) pregnancies. Similarly, histopathology also reveals lesions of vascular compromise in IUGR placenta. We evaluated an association between Doppler and histopathological (HP) assessment of the maternal and fetal circulation in IUGR. Methods IUGR cases with both Doppler and histopathology assessment were selected from our database. Doppler patterns recorded UP and FP insufficiency. The HP vascular lesions were classified as maternal vascular underperfusion and fetal thrombotic vasculopathy (FTV). IUGRs were grouped based on (i) presence of preeclampsia (PE), (ii) clinical onset (early vs late) of IUGR (early onset [EO]/late onset), and (iii) gestational age (term, T/preterm, PT). Results Abnormal Doppler waveforms were present in 69 of the total 88 IUGR cases (78.4%). The most frequent pattern was fetoplacental insufficiency (FPI) (66%) which was combined with uteroplacental insufficiency (UPI) in 49%. HP showed vascular lesions in 52.3% and most frequent was FTV (38%). PE-associated IUGR (n = 49) had higher UPI pattern (75.5% vs 43.6%, P = .004), while normotensive IUGR had higher FPI pattern (28.2% vs 8.2%, P = .01). EO-IUGR (n = 55) and PT-IUGR (n = 52) had significant abnormal Doppler waveforms ( P < .05) with higher combined patterns and brain sparing. Doppler was more sensitive for fetal vascular lesions than maternal (75.8% vs 66.7%). However, 42% of cases with normal Doppler findings showed HP vascular lesions. Conclusion IUGR pregnancies harbor significant vascular compromise. Fetal circulatory lesions were more common in IUGR pregnancies. In a significant number of cases with normal Doppler report, vascular lesions were identified on histopathology, emphasizing placental examination in all cases of IUGR.