bluuebunny/crossref_metadata_2025_split huggingface dataset:
Akkadian substrate words and meanings surfacing in Neo-Aramaic
Authors: Mutzafi Hezy 
Published: May 2018

Abstract
The present article concerns twelve cases of Akkadian lexical influences on Aramaic that are not manifest until the modern period. These are added to several cases already discussed in scholarly works, and include ten substrate words and two loan translations, all in North-Eastern Neo-Aramaic (NENA), and in one case of loan translation apparently also in Western Neo-Aramaic (assuming a westward diffusion of the innovation involved). As most Akkadian lexical influences which surface in Neo-Aramaic are confined to NENA, it seems that the main reasons for the lack of their attestation in pre-modern Aramaic is the strictly vernacular nature of the remote progenitor of NENA, and the fact that the history of this dialect group is not attested.
Plural addressee marker and grammaticalization in Barayin
Authors: Lovestrand Joseph 
Published: May 2018

Abstract
This article describes two distinct but related grammaticalization paths in Barayin, an East Chadic language. One path is from a first-person plural pronoun to a first-person dual pronoun. Synchronically, the pronominal forms in Barayin with first-person dual number must now be combined with a plural addressee enclitic, nà, to create a first-person plural pronoun. This path is identical to what has been documented in Philippine-type languages. The other path is from a first-person dative suffix to a suffix dedicated to first-person hortative. This path of grammaticalization has not been discussed in the literature. It occurred in several related languages, and each case results in a hortative form with a dual subject. Hortative forms with a plural subject are created by adding a plural addressee marker to the dual form. The plural addressee marker in Chadic languages is derived from a second-person pronominal.
Soil Moisture Drought in Europe: A Compound Event of Precipitation and Potential Evapotranspiration on Multiple Time Scales
Authors: Manning Colin , Widmann Martin , Bevacqua Emanuele , Van Loon Anne F. , Maraun Douglas , Vrac Mathieu 
Published: May 2018

AbstractCompound events are extreme impacts that depend on multiple variables that need not be extreme themselves. In this study, we analyze soil moisture drought as a compound event of precipitation and potential evapotranspiration (PET) on multiple time scales related to both meteorological drought and heat waves in wet, transitional, and dry climates in Europe during summer. Drought indices that incorporate PET to account for the effect of temperature on drought conditions are sensitive to global warming. However, as evapotranspiration (ET) is moisture limited in dry climates, the use of such drought indices has often been criticized. We therefore assess the relevance of the contributions of both precipitation and PET to the estimation of soil moisture drought. Applying a statistical model based on pair copula constructions to data from FluxNet sites in Europe, we find at all sites that precipitation exerts the main control over soil moisture drought. At wet sites PET is additionally required to explain the onset, severity, and persistence of drought events over different time scales. At dry sites, where ET is moisture limited in summer, PET does not improve the estimation of soil moisture. In dry climates, increases in drought severity measured by indices incorporating PET may therefore not indicate further drying of soil but the increased availability of energy that can contribute to other environmental hazards such as heat waves and wildfires. We therefore highlight that drought indices including PET should be interpreted within the context of the climate and season in which they are applied in order to maximize their value.
Warehouses on wheels
Authors: Orenstein Dara 
Published: May 2018

A typical depiction of a logistics corporation is a study in bright lights and blurred lines against a static landscape of territorial sovereignty. It celebrates—as in the slogan touted by the freight-carrier DHL—“logistics without borders.” This article demystifies that promise of borderlessness by explaining how the nation-state has played a lead role in facilitating the circulation of capital and in making the world safe for logistics. Specifically, I revisit two underappreciated milestones in the history of the United States: first, how Congress followed in the path of the British Empire and, in 1846, authorized the spatial form of the bonded warehouse; and second, how it went further and, in 1870, supplemented the bonded warehouse with a bonded railcar, or “warehouse on wheels.” The latter step in particular, I argue, laid a foundation for the networked geography of supply-chain capitalism. Congress permitted the bonded railcar to bypass customs clearance at ports on the seacoast and to move “directly” to ports in the interior. This protocol helped merchants expedite deliveries and generate liquidity via duty deferral, and, equally if not more importantly, it helped boosters on the urban frontiers of the Great West lure investment and spur development via the world market. What was “radical” about this innovation, as commentators noted at the time, was that it mobilized not only commodity capital but also, in effect, the national border.
Platelet-Rich Plasma Releasate Promotes Regeneration and Decreases Inflammation and Apoptosis of Injured Skeletal Muscle
Authors: Tsai Wen-Chung , Yu Tung-Yang , Chang Gwo-Jyh , Lin Li-Ping , Lin Miao-Sui , Pang Jong-Hwei S. 
Published: May 2018

Background: Platelet-rich plasma (PRP) contains various cytokines and growth factors that may be beneficial to the healing process of injured muscle. Based on the authors’ previous study, PRP releasate can promote proliferation and migration of skeletal muscle cells in vitro, so animal studies are performed to support the use of PRP to treat muscle injury in vivo. Purpose: To investigate the effect of PRP releasate on regeneration of injured muscle, as well as its effect on inflammatory reaction and cell apoptosis, in the early stages of the muscle-healing process. Study Design: Controlled laboratory study. Methods: The gastrocnemius muscles of Sprague-Dawley rats were injured by partial transverse incision and then treated with PRP releasate. Hematoxylin and eosin stain was used to evaluate the healing process of injured muscle at 2, 5, and 10 days after injury. TUNEL assay was used to evaluate the cell apoptosis of injured muscle after PRP releasate treatment. Immunohistochemistry was used to stain the CD68-positive cells during the healing process. Muscle contractile properties, including fast-twitch and tetanic strength, were evaluated by electric stimulation. Results: The results revealed that PRP releasate treatment could enhance the muscle-healing process and decrease CD68-positive cells and apoptotic cells. Furthermore, the tetanic strength was significantly higher in injured muscle treated with PRP releasate. Conclusion: In conclusion, PRP releasate could enhance the healing process of injured muscle and decrease inflammatory cell infiltration as well as cell apoptosis. Clinical Relevance: PRP promotes skeletal muscle healing in association with decreasing inflammation and apoptosis of injured skeletal muscle. These findings provide in vivo evidence to support the use of PRP to treat muscle injury.
Household Implementation of Smoke-Free Rules in Homes and Cars: A Focus on Adolescent Smoking Behavior and Secondhand Smoke Exposure
Authors: Parks Michael J. , Kingsbury John H. , Boyle Raymond G. , Evered Sharrilyn 
Published: May 2018

Purpose: This study addresses the dearth of population-based research on how comprehensive household smoke-free rules (ie, in the home and car) relate to tobacco use and secondhand smoke (SHS) exposure among adolescents. Design: Analysis of 2014 Minnesota Youth Tobacco Survey. Setting: Representative sample of Minnesota youth. Participants: A total of 1287 youth who lived with a smoker. Measures: Measures included household smoke-free rules (no rules, partial rules—home or car, but not both—and comprehensive rules), lifetime and 30-day cigarette use, 30-day cigarette and other product use, and SHS exposure in past 7 days in home and car. Analysis: Weighted multivariate logistic, zero-inflated Poisson, and zero-inflated negative binomial regressions were used. Results: Compared to comprehensive rules, partial and no smoke-free rules were significantly and positively related to lifetime cigarette use (respectively, adjusted odds ratio [AOR] = 1.80, 95% confidence interval [CI] = 1.24-2.61; AOR = 2.87, 95% CI = 1.93-4.25), and a similar significant pattern was found for 30-day cigarette use (respectively, AOR = 2.20, 95% CI = 1.21-4.02; AOR = 2.45, 95% CI = 1.34-4.50). No smoke-free rules significantly predicted using cigarettes and other tobacco products compared to comprehensive rules. In both descriptive and regression analyses, we found SHS exposure rates in both the home and car were significantly lower among youth whose household implemented comprehensive smoke-free rules. Conclusions: Comprehensive smoke-free rules protect youth from the harms of caregiver tobacco use. Relative to both partial and no smoke-free rules, comprehensive smoke-free rules have a marked impact on tobacco use and SHS exposure among youth who live with a smoker. Health promotion efforts should promote comprehensive smoke-free rules among all households and particularly households with children and adolescents.
Preconception antiphospholipid antibodies and risk of subsequent early pregnancy loss
Authors: Gibbins K J , Mumford S L , Sjaarda L A , Branch D W , Perkins N J , Ye A , Schisterman E F , Silver R M 
Published: May 2018

Objectives To prospectively estimate the association of preconception antiphospholipid antibodies (aPL) with subsequent pregnancy loss using a cohort design. aPL have been associated with recurrent early pregnancy loss (EPL) prior to 10 weeks in previous case-control studies. Prospective ascertainment of pregnancy loss is challenging, as most women do not seek care prior to EPL. Methods Secondary analysis of the Effects of Aspirin in Gestation and Reproduction trial of preconception low-dose aspirin. Preconception anticardiolipin (aCL) and anti-β2-glycoprotein-I (a-β2-I) were assessed in 1208 women with one or two prior pregnancy losses and no more than two prior live births. Comparison cohorts were defined by positive aPL (+aPL) or negative aPL (–aPL) status. All women were followed for six menstrual cycles while trying to conceive; if successful, they underwent an ultrasound at 6–7 weeks’ gestation. EPL was defined as loss prior to 10 weeks’ gestation; embryonic loss was loss after visualization of an embryo but prior to 10 weeks; clinical loss was any loss after visualization of an embryo (with or without fetal cardiac activity detected). Results In total, 14/1208 (1%) tested positive for +aPL. 786/1208 (65%) women had positive human chorionic gonadotropin during the study period, of which 9/786 (1%) had +aPL. Of the 786 pregnant women, 589 (75%) had live births and 24% had pregnancy losses. Women with +aPL experienced EPL at similar rates as women with –aPL, 44% vs 21% (aRR 2.4, 95% confidence interval (CI) 0.5–10.9). Embryonic loss was more common in women with +aCL IgM (aRR 4.8, 95% CI 1.0–23.0) and in women with two positive aPL. Clinical pregnancy loss was more common in women with positive a-β2-I IgM (50% vs 16.5%, aRR 3.7, 95% CI 1.3–10.8). Conclusion Positive levels of aPL are rare in women with one or two prior pregnancy losses and are not clearly associated with an increased rate of subsequent loss. Clinical trial registration The original source study was registered at ClinicalTrials.gov (#NCT00467363).
Early symptoms of systemic lupus erythematosus (SLE) recalled by 339 SLE patients
Authors: Leuchten N , Milke B , Winkler-Rohlfing B , Daikh D , Dörner T , Johnson S R , Aringer M 
Published: May 2018

Objective The European League Against Rheumatism and the American College of Rheumatology jointly embarked on a new classification criteria for systemic lupus erythematosus (SLE) project. Its first phase involved generation of a broad set of items potentially useful for classification of SLE. This study was undertaken to add the patient perspective to an expert Delphi approach and an early patient cohort study. Methods A national cross-sectional study was conducted. A self-report questionnaire was published in the “Schmetterling” (Butterfly), the quarterly journal of the German SLE patient association. Individuals with SLE were asked to anonymously complete the questionnaire, which asked for demographic details, organ manifestations, autoantibodies and symptoms. Results A total of 339 completed questionnaires out of 2498 were returned, a response rate of 13.6%; 83.2% reported they were ANA positive and 81.7% reported joint, 66.1% skin and 33.0% renal involvement. For the time before and in the first year after their SLE diagnosis, the majority reported fatigue (89.4%), joint pain (86.7%), photosensitivity (79.4%) and myalgia (76.1%). Of interest, more than half of the patients reported fever as an early symptom (53.7%). Conclusion For a Caucasian European SLE patient population, the overall characteristics suggest meaningful representation. While many symptoms were reported as expected, the high percentage of patients reporting fever and the significant number of patients with unexpected gastrointestinal complaints are of particular interest. These data add to the information on early SLE symptoms informing the development process of new SLE classification criteria.
Comparison of the incidence of febrile neutropenia in obese and normal weight breast cancer patients receiving myelosuppressive chemotherapy and prophylactic pegfilgrastim
Authors: Collins Jennifer M , Fleming Gini F , Christ Trevor N 
Published: May 2018

Purpose Common breast cancer chemotherapy regimens are associated with a risk of febrile neutropenia, so prophylactic colony-stimulating factors are incorporated for high-risk patients. Filgrastim utilizes weight-based dosing; however, its sustained-release formulation utilizes fixed dosing. The purpose of this study is to determine whether obese breast cancer patients who receive pegfilgrastim are at increased risk of developing febrile neutropenia. Methods This study is a single-center, retrospective chart review. Breast cancer patients were categorized as normal weight (body mass index < 30), overweight (body mass index 30–39), or obese (body mass index ≥ 40). Results A total of 442 eligible patients were identified between 1 July 2012 and 19 May 2016. Twenty-eight were included in the obese group. Twenty-eight patients from each non-obese group were randomly selected to make up the overweight and normal weight groups. Incidence of febrile neutropenia was 1, 2, and 2 of 28 in the normal weight, overweight, and obese research groups, respectively. Increased use of antibiotics was observed in the obese group as compared to the normal and overweight groups (2, 1, 1, respectively; p = 0.0005). Median number of days on antibiotics was statistically significantly higher in the obese group at 10 days compared to the normal and overweight groups at seven days ( p = 0.03). Conclusion Obese patients are not at increased risk of febrile neutropenia. However, they may have a lower threshold for febrile neutropenia and require more antibiotics after chemotherapy. Clinical significance of these results cannot be determined given the small sample size, so further multicenter studies are required.
Infections seem to be more frequent before onset of pediatric multiple sclerosis: A Danish nationwide nested case–control study
Authors: Boesen Magnus Spangsberg , Koch-Henriksen Nils , Thygesen Lau Caspar , Eriksson Frank , Greisen Gorm , Born Alfred Peter , Blinkenberg Morten , Uldall Peter Vilhelm , Magyari Melinda 
Published: May 2018

Background: Infections are suspected environmental triggers for multiple sclerosis (MS). The relationship between the timing and cumulative number of childhood infections regarding pediatric MS risk is uninvestigated. Objectives: To investigate whether childhood infections contribute to pediatric MS. Methods: A nationwide nested case–control study with detailed MS case ascertainment including chart review was undertaken. For each MS case, we selected five control children using density sampling from the entire Danish population, matching controls to children with MS by sex and birthdate. We analyzed data with the cumulative number of childhood infections as exposure and MS as outcome. Hazard ratios (HRs) including 95% confidence intervals (CIs) were estimated using Cox regression. Results: We identified 212 children with MS and 1,060 controls. Median age at MS onset was 15.3 years (range: 7.6–17.8 years); 72% were girls. Each infection during the preceding 3 years increased the hazard for MS by 11% (95% CI = 1.01–1.22, p = 0.04); having 5+ infections compared with 0–4 infections in the preceding 3 years doubled the hazard for MS (HR: 2.18; 95% CI = 1.12–4.30, p = 0.02). Conclusion: Children with MS appeared to have more infections in the 3 years preceding MS clinical onset; accordingly, immune response to infections may influence MS pathogenesis.
A rare case of ruptured aneurysm of the paramedian artery of Percheron
Authors: Sparacia Gianvincenzo , Agnello Francesco , Midiri Massimo , Iaia Alberto 
Published: May 2018

Introduction The artery of Percheron is a rare anatomic variant supplying bilateral medial thalamic nuclei and a variable portion of the rostral part of midbrain. Case report A 48-year-old female with massive subarachnoid hemorrhage due to a ruptured aneurysm of the paramedian artery of Percheron presented to the emergency room. Because of significant risk of recurrent intracranial hemorrhage, it was decided to proceed with endovascular embolization of the aneurysm. The patient was ultimately sent to a rehabilitation center and her presenting neurologic deficits showed significant improvements in the weeks following endovascular embolization treatment. Discussion The paramedian artery of Percheron is a rare anatomic variant and subarachnoid hemorrhage due to aneurysm of this artery is exceedingly rare. This case underlines the importance of a correct evaluation of cerebral arterial anatomy in order to choose the best endovascular therapeutic approach, reduce complications, and optimize patient outcome.
Using anti-Xa level for adjusting intravenous unfractionated heparin infusion in peripartum thromboembolic disease
Authors: Tse Enrica , Khurana Rshmi , Clarke Gwen , Sia Winnie 
Published: May 2018

Background Intravenous unfractionated heparin infusion is often used to minimize the duration of time without anticoagulation around delivery in pregnant patients with high thrombotic risk. Activated partial thromboplastin time is commonly used to monitor and adjust heparin dose. However, using activated partial thromboplastin time is problematic in pregnancy because activated partial thromboplastin time response to unfractionated heparin is attenuated due to elevated Factor VIII levels and may lead to incorrect dosing. Case We report a case of deep venous thrombosis occurring in a term pregnancy managed by intravenous unfractionated heparin adjusted using anti-Xa level around the time of delivery. We modified the intravenous unfractionated heparin nomogram by using anti-Xa levels instead of activated partial thromboplastin time and observed lower dosing of unfractionated heparin than otherwise required to achieve and maintain target levels. Conclusion This report demonstrates the feasibility and effectiveness of using anti-Xa level to monitor and adjust intravenous unfractionated heparin infusion in pregnancy.
Achievement of low-density lipoprotein cholesterol goals in 18 countries outside Western Europe: The International ChoLesterol management Practice Study (ICLPS)
Authors: Danchin Nicolas , Almahmeed Wael , Al-Rasadi Khalid , Azuri Joseph , Berrah Abdelkrim , Cuneo Carlos Alberto , Karpov Yuri , Kaul Upendra , Kayıkçıoğlu Meral , Mitchenko Olena , Ruiz Alvaro J , Aguilar Salinas Carlos A , Santos Raul D , Mercier Florence , Blom Dirk ,   for the ICLPS Investigators
Published: May 2018

Background Little is known about the achievement of low density lipoprotein cholesterol (LDL-C) targets in patients at cardiovascular risk receiving stable lipid-lowering therapy (LLT) in countries outside Western Europe. Methods This cross-sectional observational study was conducted in 452 centres (August 2015−August 2016) in 18 countries in Eastern Europe, Asia, Africa, the Middle East and Latin America. Patients ( n = 9049) treated for ≥3 months with any LLT and in whom an LDL-C measurement on stable LLT was available within the previous 12 months were included. Results The mean±SD age was 60.2 ± 11.7 years, 55.0% of patients were men and the mean ± SD LDL-C value on LLT was 2.6 ± 1.3 mmol/L (101.0 ± 49.2 mg/dL). At enrolment, 97.9% of patients were receiving a statin (25.3% on high intensity treatment). Only 32.1% of the very high risk patients versus 51.9% of the high risk and 55.7% of the moderate risk patients achieved their LDL-C goals. On multivariable analysis, factors independently associated with not achieving LDL-C goals were no (versus lower dose) statin therapy, a higher (versus lower) dose of statin, statin intolerance, overweight and obesity, female sex, neurocognitive disorders, level of cardiovascular risk, LDL-C value unknown at diagnosis, high blood pressure and current smoking. Diabetes was associated with a lower risk of not achieving LDL-C goals. Conclusions These observational data suggest that the achievement of LDL-C goals is suboptimal in selected countries outside Western Europe. Efforts are needed to improve the management of patients using combination therapy and/or more intensive LLTs.
Seeking virtual social support through blogging: A content analysis of published blog posts written by people with chronic pain
Authors: Tsai Samuel , Crawford Emma , Strong Jenny 
Published: May 2018

Objective People with chronic pain often have limited avenues for social support. Social isolation often develops as their abilities to engage in daily social and vocational activities decrease. With recent advancements in technology and increasing use of social media, virtual platforms such as blogging may provide opportunities for social support. This study analyzed published blog posts of people with chronic pain to investigate how social support occurs through blogging for chronic pain blog users and the nature of such online interactions. Methods A total of 810 blog posts published from January 2014 to December 2015 on 44 publicly accessible chronic pain blogs were collected and analyzed through qualitative phenomenological thematic analysis. Results The Virtual Online Support Sequence (VOSS) was identified through the exchange of online comments; this sequence defines the process by which virtual social support can be established through the process of chronic pain blogging. Three subthemes were also identified in relation to social support in the online blogging environment: (a) the virtual community of pain blogging; (b) establishing social support through the VOSS; and (c) recounting everyday experiences related to pain. Conclusions These findings suggest that blogging can be useful in seeking, receiving and providing social support for people with chronic pain. Understanding this mechanism behind establishing virtual social support may potentially encourage people with chronic pain to pursue additional support online if they have limited face-to-face opportunities.