bluuebunny/crossref_metadata_2025_split huggingface dataset:
Numerical simulation of the folding and deployment of a polymer reflector
Authors: Géradin Michel , Preumont André , Nielsen Carl Johan 
Published: December 2024

Abstract

The paper describes the methodology developed to simulate the stowing and deployment phases of a flexible reflector to be deployed from a micro-satellite (CubeSat). The reflector structure is modelled as a nonlinear shell with viscoelastic material properties. Its stowing process is described as a quasi-static equilibrium problem under inequality constraints. The constitutive law of the shell model results from a specialization of the 3-D Maxwell viscoelastic law to shell structural behavior. A simple test consisting of a viscoelastic plate under constrained displacement aims at validating the multi-branch Maxwell model implemented in the shell element. A first simulation of a reflector petal with elastic properties is performed to verify the aptitude of the methodology to simulate the folding phase and predict the resulting stresses in stowed configuration. The second numerical simulation of the same reflector petal aims at predicting its viscoelastic deformation over a time period including all phases of the deployment, in order to determine the residual shape aberrations in the deployed configuration.
Investigating the Co-loading of Doxorubicin and Melittin on Polyethylene Glycol at Different Molar Ratios Using Molecular Dynamics Simulation
Authors: Minaeian Maryam , Miraskarshahi Fatemeh Sadat , Kordzadeh Azadeh 
Published: December 2024

Abstract

The co-loading of melittin (MLT) and doxorubicin (DOX) on polyethylene glycol (PEG) at different molar ratios was investigated with molecular dynamics (MD) simulation. The interaction potential between drug molecules and PEG was evaluated with Lennard-Jones (LJ) and electrostatic potentials. Also, the conformational change was calculated to assess. The results indicated that the 1:2 (DOX: MLT) molar ratio has a strong binding energy with PEG, and also, at this molar ratio, the secondary structure of MLT is the same as that of the water medium. At a molar ratio of (2:1) (DOX: MLT), the secondary structure of the MLT and, as a result, its properties have changed, so this ratio is not suitable for co-loading of DOX and MLT on PEG. The obtained results at the molecular level are suitable for designing drug carriers based on drugs and polymers.
Fasudil alleviates lipopolysaccharides-triggered damage to BEAS-2B cells and human lung organoids by inducing CLDN4 expression
Authors: Jiang Chenghang , Xu Liming , Wang Tianpeng , Zhou Shengang , Li Gaoxiang , Zheng Yueliang 
Published: December 2024

Abstract

Fasudil, a well-known selective ROCK inhibitor, is commonly used to treat cerebral vasospasm. Recent research suggests that Fasudil may also have therapeutic potential for lung conditions such as pulmonary hypertension and acute lung injury (ALI). However, the specific mechanisms by which Fasudil protects lung tissues, especially lung epithelial cells, remain unclear. In this study, we examined the impact of Fasudil on the viability, apoptosis, and reactive oxygen species (ROS) levels in human lung epithelial cell line BEAS-2B and human lung organoids (HLOs) exposed to lipopolysaccharides (LPS). Our results show that Fasudil significantly enhances cell viability, reduces apoptosis, and decreases ROS levels in BEAS-2B cells and HLOs induced by LPS. At the molecular level, Fasudil increases the expression of CLDN4 in these cells and organoids, and the protective effects of Fasudil against LPS-induced damage are diminished in the absence of CLDN4. These findings identify CLDN4 as a key mediator of Fasudil’s protective effects on lung epithelial cells and organoids. Our study improves the understanding of Fasudil’s therapeutic mechanisms and highlights the potential for using Fasudil and/or targeting CLDN4 in the treatment of lung conditions like ALI.
Evaluation of the Antiviral Potentials Of Selected Compounds of Nigella sativa, Zingiber officinale and Allium sativum Against SARS-COV-2 Viral Main Protease
Authors: Igwe Onyekachi Fidelis , Alo Moses N. , Chukwu Chukwuma Joseph , Obenyi Hyacinth O , Cassandra Aniokete Ugonna , Ajah Monique Iheoma , Ajah Leonard Ogbonna 
Published: December 2024

Abstract

Background:
This study investigates the antiviral potential of compounds derived from Nigella sativa (black seed), Zingiber officinale (ginger), and Allium sativum (garlic) against the SARS-CoV-2 main protease, an essential enzyme for viral replication.
Objective:
To perform molecular docking analysis of selected natural compounds and evaluate their binding affinities compared to the known antiviral agent chloroquine.
Methods:
Nine ligands were docked with the SARS-CoV-2 main protease using AutoDock and Python Molecular Viewer. The ligands included:
Nigella sativa: Dithymoquinone, Thymoquinone, Thymol, Thymohydroquinone
Zingiber officinale: Gingerenone A, 6-Gingerol
Allium sativum: Allicin, Diallyl-disulfide
Binding energies, inhibition constants, and protein-ligand interactions were analyzed.
Results:
Dithymoquinone exhibited the highest binding energy of 7.39 kcal/mol and the lowest inhibition constant of 3.84 μM, significantly outperforming chloroquine, which had a binding energy of 5.33 kcal/mol and an inhibition constant of 124.62 μM. Key interactions were noted at Serine 158.
Conclusion:
Dithymoquinone demonstrates superior potential as an antiviral agent against SARS-CoV-2, highlighting the efficacy of natural compounds in antiviral strategies. This analysis provides valuable insights into the development of natural antiviral therapeutics.
ЛЕГЕНДА О ЦАРЕ СЕЛЕВКЕВ БОЛГАРСКОЙ СРЕДНЕВЕКОВОЙ КНИЖНОСТИ(ПРИМЕР ВСТРЕЧИ ПИСЬМЕННОЙ И УСТНОЙ ТРАДИЦИИ)
Authors: С.В. Алексеев 
Published: December 2024

В статье рассматривается история легендарного сюжета о царе Селевке в болгарской средневековой литературе как пример взаимодействия устной и письменной традиции. Сюжет появляется впервые в апокрифическом «Сказании о Крестном Древе» пресвитера Иеремии (X в.), где он основан на пересказе библейской книги Товит с переносом действия в евангельское время. Затем мифический царь Селевк появляется в практически несвязанном сюжете в «Болгарской апокрифической летописи» (конец XI в.) и в русском апокрифе «Легенда о братстве», сюжетно повторяющем «Сказание». Перекличка трех источников образует своеобразный «треугольник», существование которого необъяснимо в рамках одной литературной традиции. В статье показано, что легенда о Селевке может служить примером конвергенции и «круговорота» мотивов между письменной и устной традиции. Книжные и религиозные мотивы в ней переплетались со сказкой и мифом, создавая до и после появления «Сказания» новые единства.
The article considers the history of the legend of Tsar Seleucus in Bulgarian medieval literature as an example of the interaction between the oral and written traditions. The story appears for the first time in the apocryphal Legend of the Cross by Presbyter Jeremiah (10th c.), where it is based on a retelling of the Bible book of Tobit, although action took place in the time of the Gospel. Then the mythical king Seleucus appears in the Bulgarian Apocryphal Chronicle (late 11th c.) and in the Russian apocrypha The Legend of Brotherhood, which re-tells The Legend of the Cross as a narration. The roll-call of the three sources forms a kind of “triangle” whose existence is inexplicable within the framework of one literary tradition. The article shows that the legend of Seleucus can serve as an example of convergence and ‘circulation’ of motives between written and oral traditions. Literary and religious motifs in it are interwoven with fairy tale and myth, creating new entities before and after the appearance of The Legend.
РАЗВИТИЕ БРИТАНСКОГО ИСТОРИОГРАФИЧЕСКОГОКАНОНА ПОЗДНЕГО ПРОСВЕЩЕНИЯI. МИКРОСТРУКТУРА МАКРОИСТОРИЙ В. РОБЕРТСОНА
Authors: И.Е. Рудковская 
Published: December 2024

В статье анализируются особенности микроструктуры исторических трудов В. Робертсона. Выделенные в комплексах рубрик на полях его книг повторяющиеся, однотипные, кросс-сегментарные рубрики рассматриваются в качестве маркеров целенаправленных усилий Робертсона по систематизации исторических фактов.
The article analyzes the peculiarity of the microstructure of the historical works by W. Robertson. Duplicate, similar, cross-segmental rubrics, which are distinguished in the complexes of rubrics in the fields of books by W. Robertson, considered as markers of the dedicated efforts of the researcher to systematize historical facts.
«НАЧАЛЬНИК НАШИХ КУРТИН»ПЕРВЫЙ ГЕНЕРАЛ РУССКОЙ ИМПЕРАТОРСКОЙ АРМИИ КУРДСКОГО ПРОИСХОЖДЕНИЯ – ДЖАФАР-АГА
Authors: Н.З. Мосаки , Д. Пирбари 
Published: December 2024

Статья посвящена первому генералу русской императорской армии курдского происхождения, участнику Крымской войны Джафар-аге. Начав службу в 1853 г., он в 1871 г. дослужился до генерал-майора. Его военная карьера не была характерной для русского офицера, она определялась политическими мотивами. Он был лишь призван командовать курдами. Во время Крымской войны Джафар-ага содействовал привлечению на русскую сторону турецко-подданных курдов, при его непосредственном участии было сформировано два курдских полка: один – в составе Эриванского отряда (преимущественно из курдов – жителей Эриванской губернии), второй – в составе Александропольского отряда. После Крымской войны и вплоть до своей кончины Джафар-ага продолжал командовать курдами, большей частью русско-подданными, но его влияние распространялось и на турецкую территорию, что обеспечивало безопасность в пограничных областях. Его служба в русской армии имела важное значение для политики России в отношении курдов.
The article focuses on the first general of Kurdish origin in the Russian Imperial army – Jafar Agha. Having begun his service in 1853, he was promoted to the rank of major-general in 1871. His military career is not a typical one for Russian officer, as the latter were often motivated by political aspirations. Jafar Agha was enlisted into the imperial military in order to command and establish Kurdish divisions within the army. During the Crimean War (1853-56), he was tasked with recruiting Kurdish subjects of the Ottoman Empire into the Russian forces; through his direct involvement two regiments were established – one within the Yerevan division, made up primarily of Kurds of the eponymous province, and another one within the Alexandropol division. Following the war, and up until his death, Jafar Agha continued his military service commanding Kurdish regiments. Although the majority of those under his command were subjects of the Russian state, his fame and influence spread into the Ottoman territory thus providing further security for the Russian frontier regions. This articles aims to discuss and assess the importance of his role in the evolution of the Russian Empire’s relations with the Kurds.
АВТОБИОГРАФИЯ КАК СРЕДСТВО РЕАБИЛИТАЦИИНА МАТЕРИАЛАХ ЛИЧНЫХ ДЕЛ “ЛИШЕНЦЕВ”
Authors: А.П. Килин 
Published: December 2024

В раннесоветском обществе инструментом дискриминации по признаку профессиональной деятельности являлось лишение избирательных прав граждан, занимающихся торговлей. Занятие легальной формой деятельности приводило к нисходящей социальной мобильности индивида, а потребность в реабилитации была насущной необходимостью, условием выживания торговца и членов его семьи. Личное дело «лишенца» – результат документирования процесса восстановления в избирательных правах. Анализ делопроизводственных автобиографий, которые содержатся в личном деле, позволяет не только воссоздать социальный портрет человека той эпохи, но и выявить уникальные, порой трагические эпизоды биографий людей, которым суждено было жить в «эпоху перемен».
Pengaruh Setting kawasan Tamansari terhadap Temperature Humidity Index
Authors: Astuti Adindra Maharsi Kusuma , Feriadi Henry 
Published: December 2024

Title: The Effect of Environmental Setting of Tamansari on Temperature Humidity Index
Geometric shape, land cover type, and density impact increasing global temperature and microclimate comfort. Tamansari was originally a park, garden, and bathhouse for the King and his family. Today, Tamansari is a heritage tourism area surrounded by dense residential areas in the middle of Yogyakarta City. This study aims to determine how the setting of the Tamansari area affects changes in temperature and relative humidity, which impact changes in the Temperature Humidity Index (THI) on the micro-scale of the Tamansari area. The method used is descriptive quantitative analysis, and calculation analysis was performed using the (THI) equation. The study results showed that the THI value in the Tamansari area was uncomfortable, with a THI value of 27.77-32.52°C. Building coverage ratio, population, and human activities affect the THI value. The THI value can also change due to weather factors that affect the physical condition of the area, especially in open areas.
Molecular Signatures and Clinical Significance of Notch Signaling Pathway in Peripheral Blood of Patients with Alzheimer's Disease
Authors: Jia Dongdong , He Ting , Sun Lu , Wang Qunsong , Yu Haitao 
Published: December 2024

Introduction:
Alzheimer's Disease (AD) is the most common neurodegenerative disease,
and timely and effective diagnosis is essential for the prevention and treatment of AD. Peripheral
blood is readily available, inexpensive, and non-invasive, making it an ideal substrate for
screening diagnostic biomarkers.

Method:
The Notch signaling pathway is closely related to AD, so genes related to the Notch signaling
pathway may be candidate diagnostic biomarkers for AD. Here, we have performed an integrated
analysis of peripheral blood cells transcriptomics from two AD cohorts (GSE63060: Ctrl =
104, MCI = 80, AD = 145; GSE63061: Ctrl = 134, MCI = 109, AD = 139) to reveal the expression
levels of 16 Notch signals involving 100 genes.

Result:
The results have shown the changes in Notch signaling-related genes to be highly consistent
in both AD cohorts. Bioinformatics analysis has found Differentially Expressed Genes
(DEGs) related to Notch signaling to mainly play important roles in Alzheimer's disease, the
Notch signaling pathway, and the C-type lectin receptor signaling pathway. Multiple machine
learning analyses have revealed IKBKB, HDAC2, and PIK3R1 to exhibit good diagnostic value in
both AD cohorts and that they may be ideal biomarkers for early diagnosis of AD.

Conclusion:
This study has provided a comprehensive description of the molecular signatures of
the Notch signaling pathway in AD peripheral blood and a potential diagnostic model for AD clinical
screening.
Deciphering the Interlinked CXCR4-Mediated Feedback Loop Among Signaling Pathways in Diabetic Wound Healing
Authors: Sandhanam K. , Bhattacharjee Bedanta , Rynjah Damanbhalang , Kalita Pratap , Sen Saikat , Chakraborty Raja 
Published: December 2024

Abstract:
Diabetic chronic wounds and amputations are very serious complications of diabetes
mellitus (DM) that result from an integration factor, including oxygen deprivation, elevated reactive
oxygen species (ROS), reduced angiogenesis, and microbial invasion. These causative factors
lead to tenacious wounds in an inflammatory state, which eventually results in tissue aging and necrosis.
Wound healing in DM potentially targets C-X-C chemokine receptor type 4 (CXCR4) regulates
several signalling pathways. The CXCR4 signalling pathway integrated with phospholipase
C (PLC)/protein kinase-C (PKC) Ca2+ pathways, stromal cell-derived factor-1 (SDF-1), and mitogen-
activated protein kinases (MAPKs) pathway for enhancing cell chemotaxis, proliferation, and
survival. The dysregulated CXCR4 pathway is connected with poor wound healing in DM patients.
Therapeutic strategies targeting CXCR4-based molecules such as UCUF-728, UCUF-965,
and AMD3100 have been shown to enhance diabetic wound healing by altering miRNA expression,
promoting angiogenesis, and accelerating wound closure. This study indicates that CXCR4
participation in various signalling pathways makes it essential for Understanding the healing of diabetic
wounds. Using specific compounds to target CXCR4 offers a potentially effective treatment
strategy to improve wound healing in diabetes. Our understanding of CXCR4 signalling and its
regulation processes will enable us to develop more potent wound care solutions for diabetic
chronic wounds. This report concludes that CXCR4's potential therapeutic targeting shows improvements
in diabetic wound repair. This review will demonstrate that CXCR4 plays a major
role in wound healing through its various signalling pathways. Targeting CXCR4 with certain agonist
molecules shows a therapeutic approach to potentially increasing wound healing in diabetes.
By enhancing our understanding of the CXCR4 signalling mechanism in future studies, we can develop
more potential treatments for chronic diabetic wounds.
Comprehensive Analysis of circRNA and mRNA Revealing Potential Mechanism Underlying Neuroinflammation in BV2 Cells
Authors: Jiang Shiyu , Zhang Xiang , Xu Jianghui , Liu Yi , Chen Wei , Zhang Jun , Wang Jing 
Published: December 2024

Background:
The significance of circular RNAs (circRNAs) in diabetic complications
has been established. However, their role in basal and diabetic states, as well as cognitive
dysfunction, requires further investigation.

Methods:
BV-2 microglial cells were exposed to high glucose (50mM) and insulin (2μM) for 48
hours. The levels of interleukin-1beta (IL-1β), interleukin-6 (IL-6), and tumor necrosis factoralpha
(TNF-α) were assessed through quantitative polymerase chain reaction (qPCR), western
blot, and ELISA. CircRNA and messenger RNA (mRNA) sequencing were performed, and the
data were analyzed. Differentially expressed circRNAs and mRNAs were identified using
qPCR. The circRNA-miRNA interaction was predicted using Miranda and TargetScan software,
and their levels were quantified by qPCR.

Results:
The results demonstrated a significant increase in mRNA and protein levels of IL-1β,
IL-6, and TNF-α in BV2 cells treated with glucose and insulin. Five circRNAs (four upregulated
and one downregulated) were identified in both glucose and insulin groups compared to the
control. Further qPCR analysis revealed marked increases in the levels of chr17:40159331-
40159711+ and chr2:72800499-72801858- (mmu_circ_0010164) in both treatment groups. Competitive
endogenous RNA networks showed significant upregulation of mRNA levels of mitochondrial
transcription termination factor 1b (Mterf1b) and G protein subunit gamma 4 (Gng4),
accompanied by a decrease in mmu-miR-6918-3p and mmu-miR-7043-3p levels in the glucose
and insulin groups compared to the control. Knockdown of mmu_circ_0010164 significantly
inhibited the inflammatory response induced by glucose and insulin in BV-2 microglial cells.

Conclusion:
These findings indicate that both glucose and insulin can elicit inflammatory responses
in BV2 cells through the modulation of mmu_circ_0010164 levels. The underlying
mechanism may involve potential downstream targets of mmu_circ_0010164, specifically
mmu-miR-7043-3p/Gng4 and mmu-miR-6918-3p/Mterf1b. This provides novel insights into the
treatment of glucose-induced neuroinflammation.
Development of Ethical Competence Self-assessment Tool for Korean Physical Therapists
Authors: Cheon JiYeon , Kim MyungChul , Kim HaeIn , Kim Hyunsuk 
Published: December 2024

Background
As society evolves, healthcare professionals face increasing ethical conflicts. Physical therapists, tasked with patient well-being, encounter unique dilemmas that require strong professional ethics. With rising public health standards, there is a growing expectation for these therapists to exhibit high ethical awareness.

Objectives
This study aimed to develop a self-assessment tool to evaluate the ethical competence of Korean physical therapists, assess current ethical levels, and provide data for programs aimed at improving this competence.

Methods
An eight-step process for tool development and evaluation was implemented. Data were collected through an online survey of physical therapists. To ensure effectiveness, item analysis, exploratory factor analysis, and internal consistency reliability tests were conducted.

Results
The development process began with 70 items, which were refined to 48 through expert validation. An online survey with 219 physical therapists revealed five key factors explaining 65.4% of the variance, with factor loadings between 0.52 and 0.85. The internal consistency of the tool, measured by Cronbach's alpha, was 0.90, indicating acceptable reliability. The final assessment tool comprised 18 items.

Conclusion
This study successfully developed a validated self-assessment tool for measuring the ethical competence of physical therapists in Korea. The final 18-item tool, utilizing a 4 point Likert scale, is valid and reliable. It serves as a foundational resource for future research and educational initiatives aimed at improving ethical standards among Korean physical therapists.
Perspective on the Oxidative Stress Biomarkers and Antioxidant Defense Strategies
Authors: Manap Aimi Syamima Abdul , Sivapragasam Gothai 
Published: December 2024

Abstract:
Reactive oxygen and nitrogen species are produced via a variety of endogenous and exogenous
mechanisms that lead to severe impairment in human diseases. Nevertheless, thanks to
the presence of enzymatic and non-enzymatic antioxidants, which in favors of neutralizing these
species. Along with several non-enzymatic antioxidants with modest molecular masses, the human
body additionally possesses a highly potent intrinsic enzymatic antioxidant system. An imbalance
between oxidants and antioxidants in favor of the oxidants, leading to a disruption of redox
signaling and control and/or oxidative damage. These oxidative injuries are frequently linked to
cancer, aging, and neurological diseases. Direct measurements of the concentrations of reactive
species are nearly impossible due to their incredibly short half-lives and fairly expensive systems.
Therefore, rather than directly measuring reactive species, products created by oxidative damage
to proteins, lipids, and DNA are frequently utilized to estimate the degree of oxidative damage. These
oxidative damage products are typically referred to as biomarkers. The assessment of these biomarker
concentrations, as well as fluctuations in the concentration of protective antioxidants,
might provide significant information for preventing certain diseases and maintaining optimal
health. This study aims to summarize the data of the potential biomarkers related to the putative
ROS pathway that have been implicated. Additionally, the intervention using therapeutic exogenous
antioxidant as defense strategies in balancing the redox reactions and their ramifications has
also been discussed.