bluuebunny/crossref_metadata_2025_split huggingface dataset:
Burden and seasonality of RSV bronchiolitis in hospitalized children on a French Caribbean island: Practical lessons from a 13‐year study
Authors: Fléchelles Olivier , Oger Camille , Charollais Aude , Drame Moustapha , Banydeen Rishika , Najioullah Fatiha 
Published: November 2024

AbstractEpidemiology of respiratory syncytial virus (RSV) bronchiolitis in the tropics is poorly understood, complicating the effective management of RSV epidemics. The main objective was to describe the seasonality of RSV bronchiolitis epidemics and the clinical characteristics of hospitalized infants over a 13‐year period on the French Caribbean island of Martinique. Single‐center retrospective observational study including infants under 2 years of age hospitalized at the Martinique University Hospital for RSV‐positive bronchiolitis from January 2007 to December 2019. One thousand two hundred thirty‐tree cases were included. Epidemics occurred during the rainy season, beginning in September, peaking in October/November and ending in December. A distinct biennial seasonality pattern was observed, with alternating years of high and low incidence. Mean duration of epidemics was of 11 weeks. Clinical characteristics of patients were similar to those hospitalized in temperate areas. Median hospital stay was 4 days. Median age was 3 months, 14.1% of patients were born prematurely, 2.5% had congenital heart disease and 41.1% required oxygen therapy. In Martinique, RSV bronchiolitis epidemics in infants occur in a regular biennial pattern during the rainy season. An accurate knowledge of the local seasonality will allow us to better anticipate hospital organization before epidemics.
Cell Culture of a Swine Genotype 4 Hepatitis E Virus Strain
Authors: Gong Ga , Xin Jiaojiao , Lou Yongzhi , Qiong Da , Dawa Zhuoma , Gesang Zhuoma , Suolang Sizhu 
Published: November 2024

ABSTRACTHEV infection has become a global health concern. The study of HEV pathogenicity has been hindered by the lack of a suitable in vitro culture system. In the present research, we systematic demonstration of efficient replication of swine GT4 HEV in A549 cells, Huh‐7 cells, and HepG2/C3A cell lines. The results of the immunofluorescence assay and immunofluorescence confocal assay showed that swine GT4 HEV is efficiently replicated in three cell lines at 72 h postinoculation. Meanwhile, we also detected the virus titer quantified were increased at 2‐, 6,‐ and 11‐days postinoculation. Moreover, we successfully observed HEV virus particles in the cell suspension at 6 days postinoculation. This finding holds significance for advancing in vitro HEV studies.
Comparison of effects of intra‐articular diclofenac etalhyaluronate and hyaluronic acid in a monoiodoacetate rat osteoarthritis model
Authors: Tokeshi Soichiro , Suzuki‐Narita Miyako , Tajiri Ikuko , Inage Kazuhide , Takeuchi Jun , Arai Takahito , Kawarai Yuya , Terakawa Hiroakira , Ohtori Seiji , Orita Sumihisa 
Published: November 2024

AbstractDiclofenac etalhyaluronate (DF‐HA) sustained diclofenac release with the effects of hyaluronic acid (HA), offering long‐term analgesia in osteoarthritis. In this study, the effects of DF‐HA on pain improvement and osteoarthritis were evaluated in a rat knee monoiodoacetate‐induced osteoarthritis model compared to HA. Eight rats per group had been injected with monoiodoacetate (2.0 mg) or saline in the right knee for 4 weeks and were injected with either DF‐HA (1.25 mg/kg; 0.5 mg), HA (0.5 mg), vehicle which was a substrate without DF‐HA (50 μL), or saline and followed for 4 weeks. Mechanical plantar skin sensitivity was assessed weekly using the von Frey assay. Osteoarthritis changes were monitored with Larsen scores via CT imaging at every 2 weeks. The articular cartilage was analyzed using OARSI scores through H&E, Safranin‐O staining at 8 weeks. The percentage of Iba‐1 positive microglia in the spinal dorsal horn and of FG + CGRP‐labeled cells among FG‐positive cells in the dorsal root ganglion were evaluated by immunohistochemical staining. TNF‐α and IL‐6 mRNA expression levels in the knee synovium were evaluated by PCR. The DF‐HA showed significantly improved pain hypersensitivity compared with the HA at 6–8 weeks. The percentage of Iba‐1‐positive microglia was significantly lower than that in the vehicle and the percentage of FG + CGRP/FG was significantly lower than that in the HA. OARSI scores did not differ among treatment groups, Larsen scores indicated lower in the DF‐HA than in the vehicle. DF‐HA was as effective as HA in joint protection and significantly improved inflammatory pain compared to HA.
Pregnancy in Dystonia or Tourette's Patients with DBS. Fourteen News Cases and a Review of the Literature
Authors: Mehanna Raja , Tarakad Arjun , Taneff Lisa Yutong , Furr Stimming Erin 
Published: November 2024

AbstractBackgroundDeep Brain Stimulation (DBS) has been demonstrated to improve quality of life in patients with refractory dystonia and Tourette's syndrome (TS). Because of the young age at onset of these disorders, and the marked benefit from DBS, pregnancy in patients who have received DBS is becoming a more frequent clinical occurrence, although clear management guidelines are lacking.CasesWe report 14 new pregnancies in patients with dystonia or TS and DBS.Literature ReviewUpon review of the literature, 23 pregnancies in patients with dystonia or TS were previously reported in seven articles.ConclusionBased on the available data from a total of 37 pregnancies, DBS does not seem associated with worse pregnancy outcome. However, careful planning and communication between neurologist, anesthesiologist and obstetrician are key. A registry on pregnancy outcome in patients with DBS should be generated to facilitate the development of guidelines.
Value‐Added Service Strategies for Retailers Oriented to Uncertain Demand
Authors: Wang Hua , Jin Yao , Zhao Yan , Wang Cuicui , Xie Yanle 
Published: November 2024

ABSTRACTWhereas retailers pursue providing value‐added services (VAS) to capture additional markets and maximize profits, market demand uncertainty decreases retailers' incentives to provide VAS. Therefore, we analyze retailers' VAS provision strategies in the market demand uncertainty. We then investigate the VAS provision strategies and explore the impact of market demand uncertainty, competitive effects, and market loss effects on retailers' VAS provision strategies. We prove that when the market loss effect is high, the retailers provide VAS that even face lower consumer preferences. When the market loss effect is low, neither retailer offers VAS, even when consumer preferences are high. When the market loss effect and consumer preferences match each other, only one retailer offers VAS as an equilibrium strategy. The competition effect and market demand uncertainty exacerbate this result. Notably, the combination of VAS cost, competition effect, and market loss effect puts the retailer in a prisoner's dilemma under market demand uncertainty. Interestingly, the competition effect mitigates situations where retailers suffer from the prisoners' dilemma. Besides, the competition effect and market demand uncertainty exacerbate the difficulties of extracting optimal social welfare in different scenarios.
Radiomics analysis of dual‐energy CT‐derived iodine maps for differentiating malignant from benign thyroid nodules
Authors: Liu Ni , Huang Zengfa , Chen Jun , Yang Yang , Li Zuoqin , Liu Yuanzhi , Xie Yuanliang , Wang Xiang 
Published: November 2024

AbstractBackgroundMany thyroid nodules are detected incidentally with the widespread use of sensitive imaging techniques; however, only a fraction of these nodules are malignant, resulting in unnecessary medical expenditures and anxiety. The major challenge is to differentiate benign thyroid nodules from malignant ones. The application of dual‐energy computed tomography (DECT) and radiomics provides a new diagnostic approach. Studies applying radiomics from primary tumours on iodine maps to differentiate malignant from benign thyroid nodules are still lacking.PurposeTo determine the ability of an iodine map‐based radiomic nomogram in the venous phase for differentiating malignant thyroid nodules from benign nodules.MethodsA total of 141 patients with thyroid nodules who underwent DECT were enrolled and randomly assigned to the training and test cohorts between January 2018 and January 2019. The radiomic score (Rad‐score) was derived from nine quantitative features of the iodine maps. Stepwise logistic regression analysis was used to develop radiomic, clinical and combined models. Age, normalized iodine concentration (NIC), and cyst changes were used to construct the clinical model. Receiver operating characteristic (ROC) curve analysis, sensitivity and specificity were performed to analyse the ability of the models to predict malignant thyroid nodules. Calibration analysis was used to test the fitness of the models. Decision curve analysis (DCA) and nomogram construction were also performed.ResultsAccording to the clinical model, age (0.989 [0.984, 0.995]; p < 0.001), NIC (0.778 [0.640, 0.995]; p = 0.01), and cyst changes (0.617 [0.507, 0.751]; p < 0.001) were independently associated with malignant thyroid nodules. According to the combined model, age (0.994 [0.989, 0.999]; p = 0.01), NIC (0.797 [0.674, 0.941]; p = 0.008), cyst changes (0.786 [0.653, 0.947]; p = 0.01), and the rad‐score (1.106 [1.070, 1.143]; p < 0.001) were independently associated with malignant thyroid nodules. The combined model achieved satisfactory discrimination in predicting malignant thyroid nodules and had greater predictive value in the training (AUC [areas under the curve], 0.96 vs. 0.87; p = 0.01) and test (AUC, 0.90 vs. 0.79; p = 0.04) cohorts than did the clinical model.ConclusionsThe radiomics nomogram based on iodine maps is useful to distinguish malignant thyroid nodules from benign thyroid nodules.
Prediction of genetic profile of breast carcinoma on MRI using a combination of DCE‐MRI, DWI, and MR spectroscopy: A prospective observational study
Authors: Sharma Payal , Kumar Ishan , Ojha Ritu , Khanna Seema , Verma Ashish 
Published: November 2024

AbstractBackgroundClassification of breast cancer based on gene expression has emerged as the standard approach in its management, owing to the distinct prognoses and treatment responses observed among different subtypes. The aim of this study was to prospectively assess the imaging features of the molecular subtypes of breast cancer using multiparametric magnetic resonance imaging (mMRI) with the combined assessment of dynamic contrast‐enhanced magnetic resonance imaging (DCE‐MRI), diffusion‐weighted imaging (DWI), and MR spectroscopy (MRS).MethodsThis was a prospective observational single‐center cohort study, which included women with BI‐RADS 4−5 lesions on mammography/ultrasound (US) who subsequently underwent 1.5 T MRI (encompassing DCE‐MRI, DWI, and MRS). The histological subtypes of breast cancer were assessed. Estrogen receptor (ER), progesterone receptor (PR), Ki‐67 status, and human epidermal growth receptor‐2 (HER2) expression, assessed by immunohistochemistry (IHC), defined four molecular subtypes: luminal A, luminal B, HER2‐enriched (Her2en), and triple‐negative breast carcinoma (TNBC). Statistical associations between the four molecular subtypes and MRI features were investigated.ResultsFifty patients were included in the study. Circumscribed margins were significantly correlated with triple‐negative tumors compared to others (78% versus 6%, p < 0.001). Spiculated margins were observed in non‐triple negative tumors. Rim enhancement was significantly correlated to triple‐negative tumors compared to all other subtypes (71.4% versus 25%, p = 0.035). Mean apparent diffusion coefficient (ADC) values were significantly lower for luminal subtypes compared to non‐luminal subtypes (p < 0.001). The total choline (tCho) signal‐to‐noise ratio (SNR) was higher in triple‐negative tumors. A combined algorithm using DCE‐MRI, DWI, and MRS can predict TNBC and Her2en with specificity of 86.6% and 100%, respectively, and sensitivity of 100% and 85.37%, respectively.ConclusionThe combination of mMRI with DCE‐MRI, DWI, and MRS can accurately differentiate the molecular subtypes of breast carcinoma.
Does Adding TENS to Pelvic Floor Rehabilitation Effect on Urodynamics and Clinical Results in Children With Spina Bifida?
Authors: Özdemir Ayla Özge , Özel Ş. Kerem , Acar Gönül , Alataş İbrahim 
Published: November 2024

ABSTRACTIntroductionChildren with spina bifida (SB) experience a reduced quality of life due to neurogenic bladder dysfunction and the risk of renal failure later in life. Pelvic floor rehabilitation (PFR) and transcutaneous electrical nerve stimulation (TENS) have gained prominence in recent years due to their positive effects in treating different types of bladder issues in both adults and children. Our study aims to investigate the effects of using these two methods together in children with SB and to delineate their potential value for clinical practice.Materials and MethodsChildren with neurogenic bladder dysfunction due to SB who admitted to our spina bifida center were enrolled. Those patients, between 5 and 15 years of age, with only neurogenic detrusor overactivity (NDO) were randomly divided into two groups using an online computer application. While only the PFR was applied to Group PFR (n = 14), TENS was used in addition to this therapy in Group PFR + T (n = 14). The PFR sessions included abdominal massage, strength exercises, diaphragmatic breathing exercises, and contracting pelvic floor muscles. TENS was used in a standard fashion as previously described in patients with SB. Before and after treatment, patients' clinical data, dysfunctional voiding symptom score (DVSS), lower urinary tract symptoms, and quality of life scores due to urinary incontinence were evaluated. Urodynamic outcomes such as detrusor pressure, bladder capacity, contractility, and residual urine amount were also evaluated.ResultsTwenty eight children out of 750 SB patients were enrolled in our center. Children with only NDO due to SB were included in the study (Group PFR, mean age 8.3 ± + 2.7 years, 10 boys, four girls; Group PFR + T, 7.86 ± 2.03 years, eight boys, six girls). Treatment duration was 6 weeks (18 sessions). There was a decrease in voiding and lower urinary tract symptoms in both groups regardless of the use of TENS (p < 0.05). Maximum detrusor pressure significantly decreased only in the TENS group after treatment (from 82.143 ± 58.069 cmH2O to 58.077 ± 39.872 cmH2O) (p < 0.05). The difference in clinical parameters, quality of life scores and other urodynamic parameters were not found to be significant between groups.DiscussionPFR and TENS may be effective in SB with NDO to reduce voiding symptoms, and protect bladder from increased pressures. PFR seems to be a useful conservative approach in patients with NDO, adjunt to standard treatment. Further studies are needed in delineation of a personalized holistic treatment approach in these patients.ConclusionAddition of TENS to standard PFR in NDO may be effective in reducing maximum detrusor pressures, however, it does not seem to specifically contribute for improving incontinence and incontinence‐related quality of life.
News in Business News During the COVID‐19 Pandemic in New Zealand: A Content Analysis
Authors: Akhtaruzzaman Muhammad 
Published: November 2024

AbstractNew Zealand's response to the health risk of COVID‐19 has been acclaimed as a success story compared to other nations. Yet, the impact of the pandemic on New Zealand businesses and the resulting shift in business operations and priorities remained least known. The aim of this study is to identify major concerns in business‐related news in mainstream newspapers in New Zealand that impacted the businesses during the COVID‐19 pandemic. A qualitative content analysis technique was employed to analyse the news content of a total of 134 newspaper articles from the major online mainstream newspapers published in New Zealand during the pandemic. The major themes identified from the content analysis were: Business, Subsidy, Lockdown, People. Further analysis of these themes disclosed that Business and People were the predominant themes in the news content during the pandemic. The findings reveal that the concerns of businesses extended beyond operational and financial performance, also encompassing the health and well‐being of the employees and customers. The findings offer valuable insights for future research and bear significant implications for both management and policy‐making.
The Global Prevalence of Iron Deficiency in Collegiate Athletes: A Systematic Review and Meta‐Analysis
Authors: Thompson Christineil , Block Darci , Wang Zhen , Foster Nathan , Hassett Leslie C. , Steien Dana , Galardy Paul , Al‐Huniti Ahmad 
Published: November 2024

ABSTRACTAthletes are at high risk of iron deficiency even without anemia. In this systematic review and meta‐analysis that included 17,519 athletes in 122 references from 23 countries, participating in 62 unique sports over a 41‐year timeframe, approximately 53.9% of student‐athletes were found to be hypoferritinemic (ferritin concentration below 50 mcg/L) with 23.0% percent showing absolute iron deficiency based on current definitions (ferritin concentration below 20 mcg/L). These findings strongly suggest that changes in clinical practice guidelines are warranted to enable routine screening for iron deficiency among adolescent and collegiate athletes.
Health‐Related Quality of Life Among Discharged Patients With Hemophagocytic Lymphohistiocytosis: A Follow‐Up Study
Authors: Li Xiao , Yu Kun , Yan Haipeng , Xie Longlong , Wang Xiangyu , Luo Ting , Lu Xiulan , Li Xun , Xiao Zhenghui 
Published: November 2024

ABSTRACTPurposeEvaluating the post‐discharge health‐related quality of life (HRQoL) in hemophagocytic lymphohistiocytosis (HLH) and exploring its influencing factors.Patients and MethodsThe study was conducted at a regional pediatric medical center and involved pediatric patients diagnosed with HLH between July 2017 and July 2022. Healthy children of the same age and sex were included as the control group. The HRQoL and its associated factors in pediatric patients were assessed using the PedsQL 4.0 Parent Proxy Report and a general information survey.ResultsIn the first year following diagnosis, psychological health and overall score in HLH patients were worse than those of the control group. However, scores for emotional functioning, school functioning, physical health, psychosocial health, and overall scores in the HLH group increased over the years since diagnosis. By the 5‐year post diagnosis, there were no significant differences between the HLH group and the control group in social functioning, school functioning, physical health, psychosocial health, and overall scores (p > 0.05). Generalized linear model analysis revealed that HLH patients who underwent transplantation have worse social functioning, physical health, overall score, while HLH patients with HLH recurrence have worse social functioning, psychosocial health, overall score (p < 0.05).ConclusionThe HRQoL of HLH patients is compromised after discharge; however, it progressively returns to levels comparable to those of healthy cohorts over time since diagnosis. Transplantation, and HLH recurrence are identified as factors affecting the HRQoL in HLH patients.
Multilevel Facilitators and Barriers to Healthcare Organization and Delivery Among Childhood Cancer Survivors
Authors: Miller Brianna M. , Yockel Mary Rose , Appel Burton E. , Dash Chiranjeev , Harris‐Hollingsworth Nicole , Kadan Lottick Nina S. , Potosky Arnold L. , Rowland Julia , Suntum Tara , Chaillet Katherine , Sleiman Marcelo M. , Statman Muriel R. , Tercyak Kenneth P. 
Published: November 2024

ABSTRACTBackgroundChildhood cancer survivors (CCS) are at risk for medical and psychosocial late effects of their disease and its treatment and are recommended to receive annual follow‐ups. Yet, rates of follow‐up adherence are suboptimal and may be influenced by the organization and delivery of their healthcare. This research aimed to examine experts’ perceptions of facilitators and barriers to healthcare organization and delivery to CCS.ProcedureThirty‐one clinicians and administrators in a comprehensive cancer center's research consortium were interviewed about system‐level factors that may promote or deter annual follow‐ups among CCS. Interview transcripts were coded and inductively analyzed using a study‐specific scheme.ResultsThree main themes were identified: (1) healthcare system influences (59%); (2) social determinants of health (25%); and (3) intra/interpersonal factors (16%). Prominent subthemes included age‐related changes in the transition of healthcare responsibility that disrupt ongoing CCS care (28.1%), the breadth and quality of psychosocial support available to navigate CCS to follow‐up (13.5%), and transportation challenges (24.6%; especially in low‐resource areas). In contrast, community trust facilitated follow‐up (17.3%).ConclusionThe system of healthcare was prominent in receipt of follow‐up by CCS, and further influenced by social determinants of health and intra/interpersonal factors. Easing transitions of responsibility (from parents to CCS, and acute care to survivorship teams) may be beneficial, especially when social determinants of health obstacles are present. Psychosocial wrap‐around care is essential, along with promoting staff awareness of obstacles that CCS encounter in low‐resource communities.
Preparation and characterization of nanocomposites based on natural rubber/chlorobutyl rubber/graphene nanoparticle: Effect of feeding sequences, mixer type and nanoparticle concentration
Authors: Sharifi‐Teshnizi Marziye , Jalali‐Arani Azam , Santana Marianella Hernández 
Published: November 2024

AbstractBlends of natural rubber (NR)/chlorobutyl rubber (CIIR) (50/50), along with their nanocomposites containing varying amounts of graphene nanoparticles (GNPs) with and without silane, were prepared using different feeding sequences and mixers. The results indicated that when GNP was first mixed with NR before adding CIIR, the highest GNP content was found in NR; the oxygen permeability and diffusion coefficient decreased significantly by 37% and 55%, respectively. Conversely, when graphene was initially added to CIIR, it was distributed in both rubbers and at the interface, enhancing phase interaction and achieving a finer morphology. This sample exhibited the greatest improvement in mechanical properties due to specific localization of GNP and increased crosslink density. Using an internal mixer instead of a two‐roll mill improved graphene dispersion, reduced curing time, and enhanced mechanical properties. Although the presence of silane reduced graphene dispersion, it improved mechanical and barrier properties due to increased crosslink density. Oxygen permeability was reduced by up to 36% at 3 phr of GNP content with silane. This research proves that the mixing order and the type of mixing equipment are crucial in determining the final performance of rubber composites, as they significantly influence the dispersion and localization of fillers.Highlights
NR/CIIR/GNP nanocomposites were prepared by different methods and evaluated.
Adding NR/GNP to CIIR led to more presence of GNP in NR and lower permeability.
By adding CIIR/GNP to NR, GNP were placed more at interface, modulus improved.
Mixing in an internal mixer improved GNP dispersion compared to a two‐roll mill.
Silane improved mechanical and barrier properties of NR/CIIR/GNP nanocomposite.