bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bioactive glass-polycaprolactone fiber membrane and response of dental pulp stem cells in vitro
Authors: Labbaf S. , Houreh A. Baharlou , Rahimi M. , Ting Hung-Kai , Jones Jr. , Nasr-Esfahani Mh 
Published: January 2019

Abstract
The study reports the fabrication and in vitro biological evaluation of a sol-gel derived bioactive glass (BG) / polycaprolactone (PCL) composite fiber membrane, as a potential candidate for bone regeneration applications. The non woven composite mats were prepared by introducing the glass particles into the electrospinning process. Adding the glass improved the homogeneity of the fibers. The apatite forming ability of the membranes in simulated body fluid were evaluated and showed that hydroxyapatite had formed within 21 days in SBF and completely covered the surface of the membrane. In cell culture, dental pulp stem cells adhered proliferated and produced mineralized matrix on the PCL/BG fiber membrane.
Thermomechanical properties of PEGDA and its co-polymers
Authors: Rekowska Natalia , Arbeiter Daniela , Konasch Jan , Riess Alexander , Mau Robert , Eickner Thomas , Seitz Hermann , Grabow Niels , Teske Michael 
Published: January 2019

Abstract
Current research activities focus on personalized, comfortable and safe products for systemic or local drug application in patients. Poly(ethylene glycol) diacrylate is in particular interest as a drug delivery material, as it shows appropriate biological properties such as hydrophilicity and low toxicity. Additionally, as an easily photopolymerizable compound it can be also utilized for the production of scaffolds with the use of different techniques such as stereolithography. Even though it is often used as a biomaterial or as a copolymer in many photopolymer systems for drug delivery, thermomechanical analysis and basic understanding are rare.
Therefore, we investigated the tensile stress and the glass transition temperature of pure PEGDA and of its copolymers with 1,3-butanediol diacrylate or pentaerythritol triacrylate, as a function of the photoinitiator (PI) or acrylate concentration. Additionally, we demonstrated that the washing procedure decreases the tensile stress values. We showed, that by the means of composing PEGDA with these, it is possible to influence thermomechanical properties of the sample. Our outcomes have revealed, that there is no clear influence of the PI concentration on the thermomechanical properties. However there is an influence of the monomer concentration. Therefore, it should be possible to modify drug release profiles in future experiments.
The International Year of the Periodic Table 2019
Authors: Reedijk Jan , Tarasova Natalia 
Published: January 2019

Abstract

This year we celebrate the Periodic Table of Chemical Elements in the format proposed by Mendeleev in 1869, and its continued development to this day. This issue of

CI

describes several aspects of the Periodic Table, its history and celebration, and also addresses the pathways to possible new elements. In this preface we address some highlights of the papers and pay attention to the history of events that have led to IYPT2019.
Tribological Behaviour of Polymers in Terms of Plasma Treatment: A Brief Review
Authors: Al-Maliki Hayder , Kalácska Gábor 
Published: January 2019

Abstract
A review to enrich the literature concerning the effect of various plasmas on the tribological behaviour of polymers and monitor the developments of plasma for the modification of polymer surfaces over recent decades using up-to-date data. A comparative study of plasmas was conducted to identify the most useful and efficient ones which facilitate optimal improvements with regard to the characterizations of polymer surfaces and tribological properties. The studies included in this review strongly suggest that (besides Plasma-Immersion Ion Implantation, PIII) atmospheric plasmas (dielectric barrier discharges, DBD) are an effective technique in terms of modifying the characterizations of polymer surfaces thereby enhancing the tribological behaviour of polymers under different operating conditions that extends the operating life of elements within the machine.
Formation of Glycidyl Esters During The Deodorization of Vegetable Oils
Authors: Bognár Erzsébet , Hellner Gabriella , Radnóti Andrea , Somogyi László , Kemény Zsolt 
Published: January 2019

Abstract
Glycidyl esters are foodborne contaminants formed during the production of fats and oils, especially during the deodorization of palm oil. The hydrolyzed free form of glycidol has been categorized as probably carcinogenic to humans by the World Health Organization’s International Agency for Research on Cancer. The aim of this research was to study the formation of glycidyl esters during the lab-scale deodorization of the three most widely produced seed oils in the world (sunflower, rapeseed and soybean). The effects of two independent factors – temperature and residence time – were analyzed by a 32 full factorial experimental design and evaluated by response surface methodology. In accordance with findings in the literature, the greatest amount of glycidyl esters was formed in the soybean oil matrix. For all three oils, the effects of both residence time and temperature were significant, while the latter was more so. To reduce the formation of glycidyl esters, milder deodorization is required, which is limited because of the purposes sought by the thermal operation and removal of volatile minor components and contaminants.
Predicting the potential distribution of the lesser-known endemic Madras hedgehog Paraechinus nudiventris (Order: Eulipotyphla, Family: Erinaceidae) in southern India
Authors: Kumar Brawin , Babu Santhanakrishnan , Kumara Honnavalli N. 
Published: January 2019

Abstract
The Madras hedgehog (Paraechinus nudiventris) is a less-known insectivorous mammal, endemic to southern India, and known from the states of Tamil Nadu, Kerala, Karnataka, Andhra Pradesh and Telangana. The nocturnal habit, small body size and elusive nature of P. nudiventris have resulted in limited studies on its habitat selection and ecology. The confirmed locations of P. nudiventris from our field surveys and existing sight records were pooled. These geocoordinates were then used as the “occurrence location” to predict the potential distribution range of P. nudiventris in southern India based on a set of climatic and terrain variables using the MaxEnt algorithm. The predicted model shows the suitable ecological conditions in the districts of Erode, Tirunelveli, Tuticorin, Coimbatore and Tiruppur in Tamil Nadu, making them highly probable sites for its presence. Most of the predicted suitable range and high potential range fall in the non-protected semi-dry zones characterized by low annual rainfall with sparse savanna vegetation, lowland [0–750 m above sea level (asl)] and the rural areas of southern Tamil Nadu. Our findings establish the potential distribution range of this species in parts of Karnataka, Andhra Pradesh, Kerala and most of Tamil Nadu.
Chaotic mixing analysis of a novel single-screw extruder with a perturbation baffle by the finite-time Lyapunov exponent method
Authors: Liu Jian , Zhu Xiangzhe 
Published: January 2019

Abstract
The single-screw extruder with a perturbation baffle is a novel piece of equipment for polymer processing, in which the polymer melts undergo complex chaotic mixing. In this paper, from a new Lagrangian perspective, the fluid transporting mechanism in chaotic flow of the unwound screw channel was analyzed based on the finite element method. Firstly, two-dimensional velocity distributions in the unwound screw channel were calculated based on the mesh superposition technique. Fluid particle evolution processes in the extruder were tracked based on the fourth-order Runge-Kutta scheme. The numerical method used in this paper was validated by grid independence and experiments obtained from literature. Moreover, the finite-time Lyapunov exponent (FTLE) and Poincaré sections were adopted to discuss the chaotic mixing in the novel single-screw extruder. The effects of baffle width and height on the manifold structures in the flow dynamic system were analyzed. The results show that the homoclinic point of the manifold structure can give rise to chaotic mixing in the single-screw extruder. The height of the baffle is an important parameter to control the chaotic strength. In a way, increasing the height of the baffle can enlarge the kink scale and increase the stretching and folding actions, which results in the decrease of regular regions and an increase of the mixing efficiency in the single-screw extruder.
Apelin-13 serum levels in type 2 diabetic obese women: possible relations with microRNAs-107 and 375
Authors: Ashoori Mohammad Reza , Rahmati-Yamchi Mohammad , Ostadrahimi Alireza , Pahlavan-Gharebaba Reza , Mobasseri Majid , Bakhtiyari Salar , Zarghami Nosratollah 
Published: January 2019

AbstractObjectiveApelin, an adipocytokine, is up-regulated by insulin and suppresses pancreatic insulin secretion. One of the key microRNAs in insulin resistance caused by obesity, is microRNA-107. MicroRNA-375 is expressed in the pancreatic islet cells. We aimed to explore apelin-13 and microRNA-107 and 375 in obese women with type 2 diabetes (T2D).Materials and MethodsFifty obese women with newly diagnosed T2D and 50 non-diabetic obese women, as controls, were selected. Quantitative PCR and ELISA were used to measure the expression of microRNA-107 and 375 and Apelin-13 concentration, respectively. The role of apelin-13 was investigated in an in vitro model. Apoptosis was evaluated by flow cytometry.ResultsApelin-13 levels in diabetics were significantly more than controls (p=0.012). The expressions of microRNA-107 and 375 of diabetic group were increased, in comparison to the control group. There was no correlation between apelin-13 and microRNA-107 and 375 in diabetic and control groups. Significant correlations between apelin-13 and serotonin (p<0.001) and estimated average glucose (p<0.02) and insulin (p<0.03) were only observed in the diabetic group.ConclusionSerum levels of apelin-13 and circulating microRNA-107 and 375 could be used as biomarkers for diabetes, particularly in obese subjects. However, more study is needed in this field.
Activation of Phox2b-Expressing Neurons in the Nucleus Tractus Solitarii Drives Breathing in Mice
Authors: Fu Congrui , Shi Luo , Wei Ziqian , Yu Hongxiao , Hao Yinchao , Tian Yanming , Liu Yixian , Zhang Yi , Zhang Xiangjian , Yuan Fang , Wang Sheng 
Published: January 2019

The nucleus tractus solitarii (NTS) is implicated in the control of breathing, but the neuronal phenotype and circuit mechanism involved in such a physiological function remain incompletely understood. This study focused on the respiratory role of paired-like homeobox 2b gene (Phox2b)-expressing NTS neurons and sought to determine whether selective stimulation of this set of neurons activates breathing in male mice. A Cre-dependent vector encoding a Gq-coupled human M3 muscarinic receptor (hM3Dq) was microinjected into the NTS of Phox2b-Cre transgenic mice. The hM3Dq-transduced neurons were pharmacologically activated in conscious mice while respiratory effects were measured by plethysmography. We demonstrate that chemogenetic stimulation of Phox2b-expressing NTS neurons significantly increased baseline minute volume via an increase in respiratory frequency rather than tidal volume. Chemogenetic stimulation also synergized with moderate CO2stimulation to enhance pulmonary ventilatory response. Selective ablation of Phox2b-expressing NTS neurons notably attenuated a hypercapnic ventilatory response. Moreover, histological evidence revealed that stimulation of Phox2b-expressing NTS neurons increased neuronal activity of the preBötzinger complex. Finally, we presented the neuroanatomical evidence of direct projection of Phox2b-expressing NTS neurons to putative respiratory central pattern generator. Overall, these findings suggest that selective activation of Phox2b-expressing NTS neurons potentiates baseline pulmonary ventilation via an excitatory drive to respiratory central pattern generator and this group of neurons is also required for the hypercapnic ventilatory response.SIGNIFICANCE STATEMENTThe nucleus tractus solitarii (NTS) has been implicated in the control of breathing. The paired-like homeobox 2b gene (Phox2b) is the disease-defining gene for congenital central hypoventilation syndrome and is restrictively present in brainstem nucleus, including the NTS. Using a chemogenetic approach, we demonstrate herein that selective stimulation of Phox2b-expressing NTS neurons vigorously potentiates baseline pulmonary ventilation via an excitatory drive to respiratory central pattern generator in rodents. Genetic ablation of these neurons attenuates the hypercapnic ventilatory response. We also suggest that a fraction of Phox2b-expressing neurons exhibit CO2sensitivity and presumably function as central respiratory chemoreceptors. The methodology is expected to provide a future applicability to the patients with sleep-related hypoventilation or apnea.
El Concierto para Oboe y pequeña Orquesta en re mayor Op. 144 (trV 292) de Richard Strauss. Análisis y estudio del fraseo en la exposición del primer movimiento / The Concert in D major for oboe and small orchestra Op. 144 (TrV 292) of Richard Strauss. Analysis and study phrasing in the first movement
Authors: García Herrera Cecilio 
Published: January 2019

A través de este artículo se analiza el fraseo utilizado por Richard Strauss en la exposición del primer movimiento del Concierto para oboe y pequeña orquesta en remayor Op. 144 (TrV 292) en su edición de 1948. La razón de este acercamiento se debe a que por sus características, el fraseo en esta obra exige al oboísta agilidad, flexibilidad y, especialmente, un gran control de la respiración para que su interpretación no lo conduzca a un estado total de agotamiento.
ENTROPİ TABANLI TOPSIS VE VIKOR YAKLAŞIMI İLE AKADEMİSYENLER ÜZERİNDE BİR DUYGUSAL PERFORMANS DEĞERLENDİRME: BARTIN ÖRNEĞİ
Authors: Çelebi Demirarslan Pınar , Küçükönder Hande , Kıngır Said 
Published: January 2019

Bu çalışmanın amacı, çok kriterli karar verme
tekniklerinden TOPSIS ve VIKOR yöntemlerini kullanarak; tükenmişlik, iş
tatmini, duygusal emek ve işten ayrılma niyeti iş davranışlarına göre akademik
personelin duygusal performanslarının ölçülmesidir. Akademik personelin
tükenmişlik düzeyini belirleme veya duygusal emeğin etkisi üzerine çalışmalar
yapılmış ve bu çalışmalarda genellikle gelir, cinsiyet, ders yükü vb.
kriterleri ele alınmıştır. Bu çalışmada ise iş davranışları kriter olarak kabul
edilerek personelin duygusal performans değerlemesi yapılmıştır.

Çalışmanın
araştırma evrenini Bartın Üniversitesi İktisadi ve İdari Bilimler Fakültesi’nde
2015-2016 Bahar Dönemi’nde görev yapan akademik personel oluşturmaktadır.
Araştırmada verilerin toplanmasında tükenmişlik, iş tatmini, duygusal emek ve
işten ayrılma niyeti ölçeklerinden oluşan anket kullanılmıştır. Anket
sonuçlarının analizinde ilgili kriterlerin ağırlıklandırılması Entropi
yöntemiyle yapılmıştır. Daha sonra çok kriterli karar verme tekniklerinden sırasıyla
TOPSIS ve VIKOR yöntemleri kullanılarak akademik personelin duygusal performans
puanları en yüksekten en düşüğe doğru sıralanmıştır. Sonuçta iki farklı
sıralama yöntemi elde edilmiş olup TOPSIS ve VIKOR yöntemlerine göre sıralama
sonuçları karşılaştırılmıştır. İlk ve son sıralarda yer alan kişilerde
benzerlikler gözlemlenmiştir.
Changes in plasma spectral characteristics during the in vitro contact of human venous blood with granulated sorbents
Authors: Burkova N. V. , Kirichuk O. P. , Romanchuk E. V. , Davankov V. A. , Postnov V. N , Kuznetsov S. I. 
Published: January 2019

Rationale: During hemosorption procedures, it is important to investigate not only the sorption and activation characteristics of hemocontact agents, but also to assess the eﬀect of sorbents on the parameters of blood homeostasis. The intensity of hemolysis can be judged by the degree of changes in optical density of blood plasma at wavelengths corresponding to the peak absorption of hemoglobin (414, 544 and 577 nm).Aim: To assess the eﬀect of three granular sorbents (SKT-6A, HPS, Silochrome C-120) contacting human venous blood in vitro on changes in plasma spectral characteristics.Materials and methods: The blood contact was modeled at bench conditions with the use of donated blood at rotating mode. Blood samples were drawn before the experiment and after 5, 20, 40, and 60 minutes. Spectroscopic assessment was performed in the visible light range (300–700 nm) with UNICO 2802(S) spectrophotometer.Results: The interaction of the SKT-6A sorbent with blood resulted in a 17.3% decrease in the plasma optical density at a wavelength of 540 nm, compared to baseline, as soon as at 5 minute of the experiment (p < 0.05). The decline in optical density imposed by the blood contact with HPS ranged from 2.6 to 12.1% (p < 0.05) during the observation period. The sorption activity of SKT-6A and HPS prevailed over their lytic properties. On the contrary, the percentage change in the optical density of the Silochrome C-120 sorbent during its blood contact increased from 25.6 to 38.3% (p < 0.05), indicating that this sorbent was inducing hemolysis. The sorbents tested can be arranged as follows according to their ability to induce hemolysis during their contact with blood: HPS < SKT-6A < Silochrome C-120.Conclusion: The tested SKT-6A and HPS sorbents can be used as blood-contact agents for the low volume hemoperfusion. The HPS agent seems to be the most promising for routine clinical use. The Silochrome C-120 sorbent requires some chemical modifcation to improve its properties of hemocompatibility.
Evaluation of nonlinear dynamics of the cell structure damage as a promising method for personalized cancer diagnostics
Authors: Naimark O. B. , Nikityuk A. S. , Nebogatikov V. O. , Grishko V. V. 
Published: January 2019

Background:Modulation interference microscopy is one of the promising technologies for early personalized cancer diagnostics, while it gives the possibility to obtain real-time images of living functioning cells at a nanometer resolution, as well as to assess spatio-temporal changes of their intracellular structures.Aim:To identify the markers of malignant transformation of cells based on a multiple scale spatio-temporal of the data obtained by lase interferometry duringin situregistration of changes in intracellular structures.Materials and methods:The study was performed with the breast adenocarcinoma MCF-7 cell line and human kidney epithelial cells HEK 293 provided by the N.N. Blokhin National Medical Research Centre of Oncology (Moscow, Russia). Changes in fluctuation of the living cell phase thickness were measured with a laser modulation interference microscope MIM-340 (PA UOMZ, Russia). The multifractal detrended fluctuation analysis (MF-DFA) was used to assess the results obtained.Results:By comparison of the scaling exponential spectra and corresponding spectra of the singular fluctuations in the minimal and maximal diameters of the phase pictures of HEK 293 cells and MCF-7 cells, it was shown that the cancer cell dynamics has definite monofractal properties: a linear dependency of the scaling exponentsτfrom the actualqparameter and “dotted” singularity spectrum (the spectral width does not exceed 0.1). The dynamics of healthy cell demonstrated multifractal properties, such as a non-linear dependencyτ(q)and a bell shaped singularity spectrum (the spectral width over 0.1).Conclusion:We have proposed a new approach to assess the intracellular structural damage during oncogenesis. The signs of monofractality are objective criteria of malignization. The results obtained seems promising as early diagnostic markers of cancer transformation (damage) of cells and determination of tumor cell sensitivity / resistance to anti-tumor agents in an individual patient.
Description Between Cats Exposure with Toxoplasmosis Disease on Cats Owner and Not- Cats Owner in Mulyorejo Subdistrict, Surabaya City
Authors: Agustin Prayuani Dwi , Mukono J 
Published: January 2019

Abstract: Toxoplasmosis is an infectious disease caused by Toxoplasma gondii that transmitted from animals to humans. Actually, the symptoms of toxoplasmosis are asymptomatic with non-spesific and similar to other diseases. Cats are definite host of Toxoplasma gondii. The feces from infected cat contains million oocysts and infective to humans. Detection of toxoplasmosis in human can be done with a serological test to see the levels of immunoglobulin M (IgM) and immunoglobulin G (IgG) anti-toxoplasmosis. The purpose of this study was to identification toxoplasmosis and describe between exposure from cats with toxoplasmosis disease to people who own and don’t own cats in Mulyorejo Subdistrict, Surabaya City. This study was an descriptive observational research with cross sectional design in two populations. The subject was choosen randomly. This study was done to 25 respondents as cat owner and 25 respondents who weren’t. Data was collected from questionnaire and respondent’s blood sample. Prevalence of toxoplasmosis in cat owner 52% and 48% in not-cat owner. Crosstabulation showed that there were similar tendency between variables of feral cats, number of feral cats, and presence of cat’s feces to toxoplasmosis disease on cats owner and not-cats owner in Mulyorejo Subdistrict, Surabaya City.It is expected that the community is able to notice the presence of feral cats and cat’s feces around it to avoid the risk of infection from Toxoplama gondii.Keywords: Cats owner, Not-cats owner, Cat, Toxoplasmosis
Mapping And Analysis of Environmental Risk Factors Leptospirosis Incidence Based Geographic Information System (GIS) In Sampang Regency
Authors: Rahim Annisa , Yudhastuti Ririh 
Published: January 2019

Abstract: One of the zoonosis in Indonesia is leptospirosis. Leptospirosis is caused due to infection of bacteria Leptospira. There were 107 cases and 9 deaths due to leptospirosis in Sampang. The incidence of leptospirosis in Sampang was an outbreak. The purpose of this study was to map the distribution of leptospirosis cases in Sampang in 2013 and to analyze environmental risk factors of leptospirosis cases (rainfall, altitude, and the presence of flood). This study was an observational-descriptive study and used cross-sectional study design. The unit of analysis of the study was administrative regions based on the districts. There was patients of leptospirosis in 4 districts in Sampang regency, there are Sampang district, Camplong district Robatal district and Omben district. The highest incidence of leptospirosis in Sampang regency was occured in Sampang district with rainfall more than 177.6 mm, altitude less than 47mdpl, and had experienced flooding. Mapping the incidence of leptospirosis showed the distribution of leptospirosis cases tend to be concentrated in Sampang district which had a history of flooding status. The conclusion is rainfall, altitude, and presence of flood are risk factors of leptospirosis. The advice is to improve surveillance of patients with leptospirosis particularly during floods, to do outreach to the community, to perform cross-sector cooperation, to avoid or to reduce the frequency of direct contact with the flood to minimize transmission of leptospirosis.Keywords: leptospirosis incidence, risk factors, mapping