bluuebunny/crossref_metadata_2025_split huggingface dataset:
PREVALENSI PENDERITA DEMAM BERDARAH DENGUE (DBD) DI RUMAH SAKIT PTPN II BANGKATAN KOTA BINJAI TAHUN 2017
Authors: Gusvita Helvia 
Published: April 2019

Dangue Hemorrhagic Fever (DHF) is a disease caused by a dangue virus infection consisting of four types, Den-1, Den-2, Den-3, and Den-4 which are transmitted by the bite of infected Aedes Aegypti and Albopiktus mosquitoes by dangue virus from previous DHF sufferers. This research is a survey identifying the prevalence of Dangue Hemorrhagic Fever (DHF) patients admitted to PTPN II Departure Hospital in Binjai City for the 2017 period using secondary data from medical records. The data collection tool in this study using observation tables grouped by age, gender, and length of treatment then analyzed data. From the results of this study, it can be seen that the prevalence of Dengue Hemorrhagic Fever (DHF) in PTPN II Departure Hospital in Binjai City The 2017 period is based on the age group of the majority of 6-10 years as many as 14 (35%), based on the sex of 23 women patients (57.5%), based on the length of stay in the majority of 7-14 days as many as 17 people (42.5%).Keywords: Prevalence of Dengue Dengue Hemorrhagic, Dengue Dengue Hemorrhagic
HUBUNGAN STATUS GIZI DENGAN USIA MENARCHE PADA SISWI SMP NEGERI 1 KUNTO DARUSSALAM TAHUN 2016
Authors: Oktaviani Refni , Novziransyah Nanda 
Published: April 2019

Menarche is the first period experienced (menstruation) by every adolescent who will enter puberty. The age when a girl began menstruating are very varied. Several recent studies indicate that the age of menarche in adolescence has decreased in recent years. The decline in the age of menarhe caused by several factors, one of them is nutritional status. This type of research is used observational analytic to determine the relationship of nutritional status and the age of menarche in junior high school 1 Kunto Darussalam 2016 with cross sectional approach. The population in this research were all students of Junior high school 1 Kunto Darussalam totaling 210 people. Consecutive sampling method is used to take a sample with a sample of 68 people overall. The collected data include consist of primary data and secondary data. Primary data was collected by direct measurement and questionnaires, secondary data obtained from the Administration School. Analysis techniques data used are analysis techniques data univariate and bivariate. Hypothesis testing was doing at the level of significance of 0.05 or 95%.The results of this research shown the average age of menarche in junior high school 1 Kunto Darussalam 2016 is 11.66 years. From the results showed that there are differences in the average age of menarche between the nutritional status Underweight, Normalweight, Pre-Obesity and Obesity. It was found that the average age of menarche earlier occurred in student years Obesity is 10.25. Based on the analysis using Chi-Square(p-value = 0.013), it can be concluded that there is relationship between nutritional status and age of menarche. From results of this research suggested to the adolescent to live a life style and a healthy life style, so that it can achieve normal reproductive health.Key words : menarche, nutritional status
TINGKAT BURNOUT CAREGIVER KLIEN SKIZOFRENIA DI DESA KERSAMANAH KABUPATEN GARUT
Authors: Yulianti Yulianti , Iskandarsyah Aulia , Rafiyah Imas 
Published: April 2019

The prevalence of burnout in caregiver clients schizophrenia shows a fairly high rate compared with other chronic diseases. Burnout is a psychological tension that is specifically related to chronic stress experienced by individuals from day to day and is characterized by a state of physical, mental, and emotional exhaustion. This condition can cause the caregiver to experience depression or mental disorder. The purpose of this research is to indicate the burnout caregiver level of schizophrenia clients. This research is a descriptive research conducted in the Village Kersamanah, Garut Regency. The caregiver burnout rate is measured using Maslach Burnout Inventory-Human Services Survey (MBI-HSS). The results show that the burnout caregiver level of schizophrenic clients most of caregiver were at high burnout rate–sixty three percent (63%). The results of this study are expected to shade a light of knowledge in the mental treatment nursing, especially to overcome psychosocial problems, particularly in burnout that occurs in caregiver schizophrenia.Keywords: burnout, caregiver, schizophrenia
OBTAINING FILLED POLYURETHANE FOAM WITH IMPROVED OPERATIONAL PROPERTIES
Authors: Кочерженко А. , Kocherzhenko A. 
Published: April 2019

One of the most important advantages of polyurethane foam is the ability of single-stage production. Foaming and curing of this heat insulation does not require the supply of heat in connection with the exothermic fusion reaction that occurs when two or more liquid components are mixed, with simultaneous adhering of polyurethane foam to various surfaces due to good adhesion to almost any material. At the same time, this foam polymer has a low density and is able to withstand quite large loads.
Thermal insulation material with improved performance properties can be obtained with a careful selection of the granulometric and chemical composition of raw materials. This paper presents a brief overview of the foaming and shaping of polyurethane, examines the structure of developed composite insulation, and establishes the dependence of the foaming ratio of polyurethane foam on the granulometric composition of fillers, including man-made (waste mining industry Stoylensky GOK). The research results show that in the process of forming filled polyurethane foams, chemical reactions between the components of the polyurethane foam and the elements of the fillers do not occur. The foaming process depends mainly on the granulometry of the filler and its percentage in the total mass of polyurethane foam.
Использование акустических моделей при расчете ступени вентилятора турбореактивного двухконтурного двигателя
Authors: Кисляк М. И. , Митрахович М. М. 
Published: April 2019

Произведено сравнение экспериментальных акустических показателей вентилятора турбореактивного двухконтурного двигателя с показателями, которые получены путем моделирования с использованием различных акустических моделей.
Засоби радіоелектронної розвідки Російської Федерації
Authors: Романов О. 
Published: April 2019

Розглянуто мобільні комплекси радіорозвідки коротко- і ультракороткохвильового діапазонів частот та радіотехнічної розвідки тактичної ланки, що застосовуються в Російській Федерації. Найбільша увага приділяється сучасним зразкам, що прийняті на озброєння за останнє десятиріччя.
Розрахункове визначення деривації артилерійських снарядів
Authors: Шийко О. М. , Полениця П. В. , Сергієв С. В. 
Published: April 2019

Наводиться система диференціальних рівнянь для розрахункового визначення деривації артилерійських снарядів, стабілізованих обертанням, яка складається з диференціальних рівнянь руху центра мас снаряда і диференціального рівняння зміни кутової швидкості обертання снаряда при русі по траєкторії в результаті аеродинамічного тертя.
Визначення критеріїв та методів оцінювання шляхів забезпечення військових формувань озброєнням та військовою технікою
Authors: Borokhvostov Ihor , Bilokur Mykola 
Published: April 2019

Визначений напрям досліджень щодо пошуку можливих шляхів забезпечення військових формувань озброєнням та військовою технікою та обґрунтовані основні альтернативні варіанти. Визначені головні етапи та фактори або критерії, що впливають на прийняття відповідних управлінських рішень у цій сфері, розроблено алгоритм їх когнітивного аналізу. Визначено доцільні методи експертного оцінювання альтернативних варіантів забезпечення озброєнням та військовою технікою на кожному етапі, а також роль автоматизації та штучного інтелекту в цьому процесі.
Построение области устойчивости цифровой системы наведения и стабилизации танковой пушки в плоскости варьируемых констант алгоритма стабилизации
Authors: Aleksandrova T. Ye. 
Published: April 2019

Рассматривается упрощенная методика выбора области возможных значений варьируемых параметров цифровой системы наведения и стабилизации танковой пушки, в качестве которой используется область устойчивости замкнутой системы.
Формализация задачи синтеза облика зенитной ракетной системы нового поколения на основе системно-концептуального подхода
Authors: Nikolaiev I. M. 
Published: April 2019

Рассмотрен один из возможных подходов к формализации задачи формирования рационального технического облика зенитной ракетной системы нового поколения с учетом ресурсных ограничений. Показано, что решение этой задачи в методологическом плане требует разработки системы имитационно-математических моделей, описывающих процесс боевого функционирования ЗРС при выполнении совокупности боевых задач в прогнозируемых условиях ведения боевых действий. Приводится алгоритм формирования облика ЗРС, предусматривающий выполнение функционального, технического и конструктивного синтеза по критериям максимума боевого показателя эффективности ЗРС и минимума стоимости создания ее подсистем с требуемыми характеристиками. Показано, что предложенный подход позволяют поднять уровень обоснованности тактико-технических требований и технических предложений по созданию ЗРС нового поколения и структурировать этот процесс в виде последовательности взаимоувязанных процедур, что, в свою очередь, позволит перейти к разработке методик и формализации основных этапов функционального и схемотехнического проектирования ЗРС нового поколения.
Обґрунтування мінімально необхідних вимог до засобів вимірювань при двоступеневій системі діагностування в процесі поточного ремонту військової техніки зв'язку
Authors: Ryzhov Ye. V. , Sakovych L. M. , Nastyshyn Y. A. , Kyryllova N. V. 
Published: April 2019

Актуальність статті полягаю у мінімізації витрат на метрологічне обслуговування військової техніки зв’язку у зв’язку з недостатнім фінансуванням заходів технічної експлуатації в цілому. У статті обґрунтовано мінімально необхідні вимоги до засобів вимірювань при двоступеневій системі діагностування в процесі поточного ремонту військової техніки зв’язку, що забезпечує зменшення часу її відновлення за рахунок вдосконалення діагностичного забезпечення. Запропонована блок-схема алгоритму мінімізації вартості засобів вимірювань при збереженні необхідного рівня ремонтопридатності військової техніки зв’язку. Отримані результати дозволяють оцінити якість метрологічного забезпечення технічного обслуговування та поточного ремонту військової техніки зв’язку. Показано порядок використання отриманих результатів на прикладі розробки діагностичного забезпечення блоку електроживлення збуджувача і радіоприймача радіостанції середньої потужності Р-161 та приведено її діагностичну модель у вигляді графа інформаційно-енергетичних зв'язків.Встановлено, що ефект від використання отриманих у статті результатів полягає в зниженні до 18% середнього часу відновлення радіостанції середньої потужності Р-161 за рахунок вдосконалення діагностичного та метрологічного забезпечення. Отримані результати доцільно використовувати при кількісній оцінці показників діагностичного забезпечення військової техніки зв’язку.
TESS Delivers Its First Earth-sized Planet and a Warm Sub-Neptune*
Authors: Dragomir Diana , Teske Johanna , Günther Maximilian N. , Ségransan Damien , Burt Jennifer A. , Huang Chelsea X. , Vanderburg Andrew , Matthews Elisabeth , Dumusque Xavier , Stassun Keivan G. , Pepper Joshua , Ricker George R. , Vanderspek Roland , Latham David W. , Seager Sara , Winn Joshua N. , Jenkins Jon M. , Beatty Thomas , Bouchy François , Brown Timothy M. , Butler R. Paul , Ciardi David R. , Crane Jeffrey D. , Eastman Jason D. , Fossati Luca , Francis Jim , Fulton Benjamin J. , Gaudi B. Scott , Goeke Robert F. , James David , Klaus Todd C. , Kuhn Rudolf B. , Lovis Christophe , Lund Michael B. , McDermott Scott , Paegert Martin , Pepe Francesco , Rodriguez Joseph E. , Sha Lizhou , Shectman Stephen A. , Shporer Avi , Siverd Robert J. , Soto Aylin Garcia , Stevens Daniel J. , Twicken Joseph D. , Udry Stéphane , Villanueva Steven , Wang Sharon X. , Wohler Bill , Yao Xinyu , Zhan Zhuchang 
Published: April 2019

Abstract
The future of exoplanet science is bright, as Transiting Exoplanet Survey Satellite (TESS) once again demonstrates with the discovery of its longest-period confirmed planet to date. We hereby present HD 21749b (TOI 186.01), a sub-Neptune in a 36 day orbit around a bright (V = 8.1) nearby (16 pc) K4.5 dwarf. TESS measures HD 21749b to be

R
⊕, and combined archival and follow-up precision radial velocity data put the mass of the planet at

M
⊕. HD 21749b contributes to the TESS Level 1 Science Requirement of providing 50 transiting planets smaller than 4 R
⊕ with measured masses. Furthermore, we report the discovery of HD 21749c (TOI 186.02), the first Earth-sized (

) planet from TESS. The HD 21749 system is a prime target for comparative studies of planetary composition and architecture in multi-planet systems.
The Myriapoda of Halimun-Salak National Park (Java, Indonesia): overview and faunal composition
Authors: Hilgert Michael , Akkari Nesrine , Rahmadi Cahyo , Wesener Thomas 
Published: April 2019

The myriapod fauna of the mega-diverse country of Indonesia is so far insufficiently known, with no species lists or determination keys. In order to obtain an overview of the faunal composition of the Myriapoda in an Indonesian forest system, the fauna of the Halimun-Salak National Park in western Java was explored during the dry season (September–October 2015) in the framework of the German-Indonesian INDOBIOSYS project (Indonesian Biodiversity Discovery and Information System). A total of 980 Myriapoda specimens were collected by hand by 3–4 researchers from three different sites in the national park, from which 796 specimens were determined to a higher taxonomic level (class, order, family) and 617 specimens were determined to morphospecies. Among these, 27 were Symphyla (4%) (excluded from further analyses), 226 Chilopoda (28%) and 543 Diplopoda (68%). The Scolopendromorpha (64% of all identified centipedes) and Polydesmida (69% of all identified Diplopoda) were the most represented orders in our samples.Twenty-four morphospecies of Chilopoda were determined: one each of Scutigeromorpha and Lithobiomorpha, six Scolopendromorpha and sixteen Geophilomorpha. Nine orders of diplopods were present, with a total of 47 morphospecies: one each of Polyxenida, Glomeridesmida and Chordeumatida, two each of Glomerida, Spirobolida and Siphonophorida, seven of Sphaerotheriida, ten of Spirostreptida and 21 of Polydesmida.Two species curves were obtained to have a first idea about the myriapod diversity in the Halimun-Salak National Park and to compare the three individual collecting sites.Our results depict the Scolopendromorpha as the most common centipedes in Javanese rainforests and the Geophilomorpha as the most species-rich order. In contrast, the Polydesmida were the most dominant millipede group with 167 specimens and with 13 morphospecies the family Paradoxosomatidae was the most diverse.
Effect of Concomitant Disease-modifying Antirheumatic Drugs and Methotrexate Administration Route on Biologic Treatment Durability in Rheumatoid Arthritis: OBRI Cohort Results
Authors: Lau Arthur N. , Thorne J. Carter , Movahedi Mohammad , Rampakakis Emmanouil , Cesta Angela , Li Xiuying , Couto Sandra , Sampalis John , Bombardier Claire ,   the OBRI Investigators
Published: April 2019

Objective.Prior studies have suggested that concurrent conventional synthetic disease-modifying antirheumatic drug (csDMARD) therapy enhances the efficacy of biologic DMARD (bDMARD). Here, we assessed the effect of concomitant csDMARD use and methotrexate (MTX) route of administration on time to bDMARD discontinuation in a large Canadian (Ontario), observational, rheumatoid arthritis (RA) cohort.Methods.Patients from the Ontario Best Practices Research Initiative (OBRI) who initiated bDMARD therapy and had ≥ 1 followup assessment were included. The effect of concomitant csDMARD use (primary analysis) and MTX route of administration (secondary analysis) on bDMARD discontinuation owing to (1) any reason, (2) ineffectiveness, (3) adverse events (AE), and (4) both (2) and (3), were assessed with multivariate Cox regression.Results.Among the 814 patients included, 153 (18.8%) received bDMARD monotherapy and 661 (81.2%) combination csDMARD/bDMARD therapy. Over a mean followup of 1.9 years, bDMARD were discontinued in 38.7% of patients. In multivariate analysis, there was a nonsignificant trend toward lower discontinuation for the csDMARD/bDMARD group compared to bDMARD monotherapy for any reason (HR 0.76, 95% CI 0.55–1.05) and owing to ineffectiveness/AE (HR 0.73, 95% CI 0.50–1.06). Further, patients taking combination therapy had significantly lower risk of bDMARD discontinuation due to AE (HR 0.43, 95% CI 0.24–0.76). In the secondary analysis, no statistical association between MTX dose or route of administration and bDMARD durability was observed.Conclusion.Concomitant csDMARD use was associated with a significantly lower hazard for bDMARD discontinuation due to AE among patients with RA followed in routine clinical practice in Ontario, Canada. Neither MTX route of administration nor dose were significant predictors of bDMARD durability.
Bacteremia in Systemic Lupus Erythematosus in Patients from a Spanish Registry: Risk Factors, Clinical and Microbiological Characteristics, and Outcomes
Authors: Rúa-Figueroa Iñigo , López-Longo Francisco J. , Del Campo Víctor , Galindo-Izquierdo María , Uriarte Esther , Torre-Cisneros Julián , Vela Paloma , Tomero Eva , Narváez Javier , Olivé Alejandro , Freire Mercedes , Salgado Eva , Andreu José Luis , Martínez-Taboada Víctor , Calvo-Alén Jaime , Hernández-Cruz Blanca , Raya Enrique , Quevedo Víctor , Expósito Pérez Lorena , Fernández-Nebro Antonio , Ibañez Mónica , Pascual-Valls Èlia , Rúa-Figueroa David , Naranjo Antonio , Pego-Reigosa José M. 
Published: April 2019

Objective.To describe the incidence of bacteremia in a large multicentric cohort of patients with systemic lupus erythematosus (SLE) and their clinical characteristics and to identify risk factors.Methods.All bacteremic episodes from the Spanish RELESSER registry were included. Clinical and laboratory characteristics concerning bacteremia and SLE status, as well as comorbidities at the time of infection, were retrospectively collected. A comparison with sex- and age-matched SLE controls without bacteremia was made. A logistic regression was conducted.Results.The study included 114 episodes of bacteremia in 83 patients. The incidence rate was 2.7/1000 patient-years. At the time of bacteremia, the median age was 40.5 (range: 8–90) years, and 88.6% of patients were female. The Safety of Estrogens in Lupus Erythematosus National Assessment–Systemic Lupus Erythematosus Disease Activity Index was 4 [interquartile range (IQR) 8]; 41% had an SLE flare (66% severe); Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index was 3 (IQR 4). A comorbidity was recorded in 64% of cases. At the time of bacteremia, 88.6% received corticosteroids (68.6% > 10 mg/day) and 57% immunosuppressors. Gram-negative bacilli, most frequently Escherichia coli (29.8%), caused 52.6% of the episodes. The bacteremia-related mortality was 14% and bacteremia was recurrent in 27.2% of cases. A dose-response relationship was found between corticosteroids and bacteremia risk. In the multivariate analysis, these factors were associated with bacteremia: elevated creatinine (OR 1.31, 95% CI 1.01–1.70; p = 0.045), diabetes (OR 6.01, 95% CI 2.26–15.95; p < 0.001), cancer (OR 5.32, 95% CI 2.23–12.70; p < 0.001), immunosuppressors (OR 6.35, 95% CI 3.42–11.77; p < 0.001), and damage (OR 1.65, 95% CI 1.31–2.09; p < 0.001).Conclusion.Bacteremia occurred mostly in patients with active SLE and was frequently associated with severe flares and corticosteroid use. Recurrence and mortality were high. Immunosuppressors, comorbidities, and disease-related damage were associated with bacteremia.
Efficacy and Pharmacodynamic Modeling of the BTK Inhibitor Evobrutinib in Autoimmune Disease Models
Authors: Haselmayer Philipp , Camps Montserrat , Liu-Bujalski Lesley , Nguyen Ngan , Morandi Federica , Head Jared , O’Mahony Alison , Zimmerli Simone C. , Bruns Lisa , Bender Andrew T. , Schroeder Patricia , Grenningloh Roland 
Published: April 2019

Abstract
Because of its role in mediating both B cell and Fc receptor signaling, Bruton’s tyrosine kinase (BTK) is a promising target for the treatment of autoimmune diseases such as rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). Evobrutinib is a novel, highly selective, irreversible BTK inhibitor that potently inhibits BCR- and Fc receptor–mediated signaling and, thus, subsequent activation and function of human B cells and innate immune cells such as monocytes and basophils. We evaluated evobrutinib in preclinical models of RA and SLE and characterized the relationship between BTK occupancy and inhibition of disease activity. In mouse models of RA and SLE, orally administered evobrutinib displayed robust efficacy, as demonstrated by reduction of disease severity and histological damage. In the SLE model, evobrutinib inhibited B cell activation, reduced autoantibody production and plasma cell numbers, and normalized B and T cell subsets. In the RA model, efficacy was achieved despite failure to reduce autoantibodies. Pharmacokinetic/pharmacodynamic modeling showed that mean BTK occupancy in blood cells of 80% was linked to near-complete disease inhibition in both RA and SLE mouse models. In addition, evobrutinib inhibited mast cell activation in a passive cutaneous anaphylaxis model. Thus, evobrutinib achieves efficacy by acting both on B cells and innate immune cells. Taken together, our data show that evobrutinib is a promising molecule for the chronic treatment of B cell–driven autoimmune disorders.