bluuebunny/crossref_metadata_2025_split huggingface dataset:
Contributions to the knowledge of moths of Bombycoidea Latreille, 1802 (Lepidoptera: Heterocera) of Bhutan with new records
Authors: Irungbam Jatishwor Singh , Irungbam Meenakshi Jatishwor 
Published: June 2019

An annotated checklist of the superfamily Bombycoidea (Lepidoptera) of Bhutan is given, including three taxa of the family Bombycidae, two of Brahmaeidae, four of Endromidae, 12 of Eupterotidae, 37 of Saturniidae, and 93 of Sphingidae. Among these, 14 taxa are new records for the country: two Bombycidae (Penicillifera apicalis (Walker, 1862) and Trilocha varians (Moore, 1855)), two Endromidae (Mustilizans hepatica (Moore, 1879) and Comparmustilia sphingiformis (Moore, 1879)), three Saturniidae (Saturnia cidosa Moore, 1865, Loepa sikkima (Moore, [1866]), and Salassa thespis (Leech, 1890)), and seven Sphingidae (Rhodoprasina floralis (Butler, 1876), Amplypterus mansoni mansoni (Clark, 1924), Acosmerycoides harterti (Rothschild, 1895), Hippotion celerio (Linnaeus, 1758), Theretra tibetiana Vaglia & Haxaire, 2010, T. silhetensis silhetensis (Walker, 1856), and Cechenena helops helops (Walker, 1856)).
The On the importance of alpha behavior integrity in male Capybara Hydrochoerus hydrochaeris (Mammalia: Rodentia: Caviidae) following immuno-contraceptive treatment
Authors: Rosenfield Derek Andrew , Schilbach Pizzutto Cristiane 
Published: June 2019

As the human population continues to grow, habitat for wildlife shrinks, driving fauna either into extinction or into new habitats, which can create new problems. In Brazil, the Capybara Hydrochoerus hydrochaeris has become a pest by invading urban and agricultural areas. These mammals quickly multiply owing to abundant food supply and a lack of natural predators, and they can serve as amplifying hosts for Rickettsia rickettsii, the pathogen of potentially life-threatening Brazilian spotted fever. Species-specific population management strategies that respect public opinion and consider animal welfare are required for the effective mitigation of this tick-borne zoonotic disease. In order to control Capybara populations it is necessary to take into account their social dynamics, which are centered on polygynous dominant males with hormone-driven secondary sexual characteristics. To be a viable management tool, a contraceptive strategy targeting these males must preserve their social status to prevent other males from replacing them. As part of a larger research project on the efficiency of anti-Gonadotropin-releasing hormone (GnRH) vaccine treatment in free-ranging Capybaras, the aim of this study was to observe the impact of this treatment on alpha male and overall social group behavior. At the end of the 18-month-study, there were no recorded births involving the immunized animals, and alpha male sexual characteristics and group integrity were preserved. These results encourage the use of this anti-GnRH vaccine as an alternative population control tool in male Capybara.
Changed cortical risk gene expression in major depression and shared changes in cortical gene expression between major depression and bipolar disorders
Authors: Scarr Elizabeth , Udawela Madhara , Dean Brian 
Published: June 2019

Background: Mood disorders likely occur in someone with a genetic predisposition who encounters a deleterious environmental factor leading to dysregulated physiological processes due to genetic mutations and epigenetic mechanisms altering gene expression. To gain data to support this hypothesis, we measured levels of gene expression in three cortical regions known to be affected by the pathophysiologies of major depression and bipolar disorders. Methods: Levels of RNA were measured using the Affymetrix™ Human Exon 1.0 ST Array in Brodmann’s areas 9, 10 and 33 (left hemisphere) from individuals with major depression, bipolar disorder and age- and sex-matched controls with changed expression taken as a fold change in RNA ⩾1.2 at p < 0.01. Data were analysed using JMP® genomics 6.0 and the probable biological consequences of changes in gene expression determined using Core and Pathway Designer Analyses in Ingenuity Pathway Analysis. Results: There were altered levels of RNA in Brodmann’s area 9 (major depression = 424; bipolar disorder = 331), Brodmann’s area 10 (major depression = 52; bipolar disorder = 24) and Brodmann’s area 33 (major depression = 59 genes; bipolar disorder = 38 genes) in mood disorders. No gene was differentially expressed in all three regions in either disorder. There was a high correlation between fold changes in levels of RNA from 112 genes in Brodmann’s area 9 from major depression and bipolar disorder ( r2 = 0.91, p < 0.001). Levels of RNA for four risk genes for major depression were lower in Brodmann’s area 9 in that disorder. Conclusion: Our data argue that there are complex regional-specific changes in cortical gene expression in major depression and bipolar disorder that includes the expression of some risk genes for major depression in those with that disorder. It could be hypothesised that the common changes in gene expression in major depression and bipolar disorder are involved in the genesis of symptoms common to both disorders.
The financial sustainability of local authorities in England and Spain: a comparative empirical study
Authors: Rodríguez Bolívar Manuel Pedro , López Subires María Deseada , Alcaide Muñoz Laura , Navarro Galera Andrés 
Published: June 2019

In recent years, the financial sustainability of local authorities has been recognised as a concept of crucial importance in ensuring that public services may continue to be delivered to future generations. Although many European countries have implemented programmes to enhance their financial sustainability, local authorities are characterised by differing administrative traditions and achieve diverse outcomes in response to the reforms made. Taking a comparative approach, the present study identifies institutional, macroeconomic and microeconomic factors that might influence local authorities’ financial sustainability in England and Spain in order to determine and explain similarities and differences in the drivers and risk factors for financial sustainability in local authorities’ provision of public services. Points for practitioners This article is based on three major theories (agency theory, neo-institutional theory and stakeholder theory) related to the institutional, macroeconomic and microeconomic factors determining financial sustainability and aims to identify these factors comparing different contexts (English and Spanish contexts). This identification of factors that influence municipal financial sustainability could clarify what policymakers might have done to prevent the crisis, what they should do to prevent similar failures in the future and how the long-term provision of public services may be ensured.
Talent management and talented employees’ attitudes: mediating role of perceived organisational support
Authors: Mensah James Kwame 
Published: June 2019

This study responds to calls to examine the mechanism through which talent management affects talented employees’ attitudes. Anchored on exchange theories, this study examines a salient mechanism, perceived organisational support, through which talent management practices might affect talented employees’ attitudes. Data were obtained from a cross-sectional survey of 242 talented employees in the Ghanaian banking sector and analysed with the use of the structural equation modelling analytical technique. Our findings show that talent management has not only a direct effect, but also an indirect effect, on talented employees’ attitudes of affective commitment and quit intention through perceived organisational support. The study has implications for the management of talented employees. Points for practitioners The effectiveness of organisational support systems exists not only in the practices themselves, but also in the perceptions that employees have of those practices. For organisations to benefit fully from the implementation of talent management, managers must inform talent pool members of their status and constantly communicate talent management practices. While directly impacting affective commitment and intention to quit, talent management also operates through a path connecting perceived organisational support to these attitudes.
Selective brain hypothermia: feasibility and safety study of a novel method in five patients
Authors: Seyedsaadat Seyed Mohammad , Marasco Silvana F , Daly David J , McEgan Robin , Anderson James , Rodgers Seth , Kreck Thomas , Kadirvel Ramanathan , Kallmes David F 
Published: June 2019

Background/objective: Reduction of brain temperature remains the most common method of neuroprotection against ischemic injury employed during cardiac surgery. However, cooling delivered via the cardiopulmonary bypass circuit is brief and cooling the body core along with the brain has been associated with a variety of unwanted effects. This study investigated the feasibility and safety of a novel selective brain cooling approach to induce rapid, brain-targeted hypothermia independent of the cardiopulmonary bypass circuit. Methods: This first-in-human feasibility study enrolled five adults undergoing aortic valve replacement with cardiopulmonary bypass support. During surgery, the NeuroSave system circulated chilled saline within the pharynx and upper esophagus. Brain and body core temperature were continuously monitored. Adverse effects, cardiopulmonary function, and device function were noted. Results: Patient 1 received cooling fluid for an insignificant period, and Patients 2-5 successfully underwent the cooling procedure using the NeuroSave system for 56-89 minutes. Cooling fluid was 12°C for Patients 1-3, 6°C for Patient 4, and 2°C for Patient 5. There were no NeuroSave-related adverse events and no alterations in cardiopulmonary function during NeuroSave use. Brain temperature decreased by 3°C within 15 minutes and remained at least 3.5°C colder than the body core. During a brief episode of hypotension in one patient, the brain cooled an additional 4°C in 2 minutes, briefly reaching 27.4°C. Conclusion: The NeuroSave system can induce rapid brain-targeted hypothermia and simultaneously maintain a favorable body–brain temperature gradient, even during hypotension. Further studies are required to evaluate the function of the system during longer periods of use.
A multi-centre, prospective, randomised controlled feasibility study of plantar resistance exercise therapy for venous leg ulcers – Results of the PREVUE study
Authors: Jonker Leon , Todhunter Jane , Schutter Jose , Halliday Charlotte , Fisher Stacey 
Published: June 2019

Objectives To evaluate the feasibility of an interventional study involving a seated plantar resistance exercise programme, using a StepIt pedal, aimed at promotion of venous leg ulcer healing. Methods Thirty-two venous leg ulcer patients, recruited from community, GP and hospital settings, were randomised to either a standard care or adjuvant StepIt exercise programme arm for up to 12 weeks. The exercise involved a twice daily routine of 10 times 1 min of exercise, i.e. 2 s push and 2 s lift repetitions (equating to 300 daily ‘steps’). Results Complete healing of the venous leg ulcers was observed in 10 out of 15 (67%; StepIt cohort) and 7 out of 17 (41%; control cohort), respectively (p-value 0.18, Fisher’s exact test). Baseline differences between the two cohorts were longer wound chronicity, less venous leg ulcer-related pain and better venous leg ulcer-related quality of life in the StepIt cohort. One adverse event, involving increased wound exudate and slough production, was observed in a participant using StepIt, and no study withdrawals were recorded in either arm. StepIt users whose wound had completely healed by week 12 were more likely to be compliant with the exercise programme (self-reported) and more positive about the trial experience; however, all would recommend the device to others. Conclusions Seated plantar resistance exercise shows promise and may accelerate venous leg ulcer wound healing. The StepIt pedal is well-received by patients, and its efficacy may depend on the degree of patient compliance with the exercise programme. Further larger scale studies are indicated to allow more concrete inferences to be made on the clinical and potential health economics impact that this device may have.
Hyperbilirubinemia as a predictor of severity of acute appendicitis
Authors: Akai Masaaki , Iwakawa Kazuhide , Yasui Yuichi , Yoshida Yusuke , Kato Takuya , Kitada Koji , Hamano Ryosuke , Tokunaga Naoyuki , Miyaso Hideaki , Tsunemitsu Yosuke , Otsuka Shinya , Inagaki Masaru , Iwagaki Hiromi 
Published: June 2019

Objective This study aimed to investigate the clinical significance of preoperative hyperbilirubinemia in Japanese patients and to assess its clinical potential as a predictor of the severity of acute appendicitis. Methods We studied 318 patients with appendicitis who underwent appendectomy between July 2010 and June 2017. We analyzed preoperative data including age, sex, white blood cell count, C-reactive protein (CRP) level, fever, peritoneal irritation signs, and serum total bilirubin level as potential risk factors for complicated (perforated or gangrenous) appendicitis, using multivariate analysis. Results Complicated appendicitis was significantly more frequent in patients with hyperbilirubinemia (>1.1 mg/dL), high CRP level (>0.5 mg/dL), positive peritoneal irritation signs, and fever (>37.3°C). Multivariate analysis revealed older age (>64 years), hyperbilirubinemia, high CRP level, and fever (odds ratios 3.36, 1.75, 7.61, and 2.43, respectively) as risk factors for complicated appendicitis. Multivariate analysis also identified hyperbilirubinemia, high CRP level, and fever (odds ratios 1.99, 5.90, and 2.72, respectively) as risk factors for complicated appendicitis among patients aged <65 years. Conclusions Hyperbilirubinemia, high CRP level, and fever may be useful predictors of the severity of acute appendicitis, with hyperbilirubinemia being especially useful among patients aged <65 years.
Effets des émotions et de la personnalité de la marque sur l’engagement du consommateur via les effets médiateurs de la confiance et de l’attachement à la marque
Authors: Valette-Florence Rita , Valette-Florence Pierre 
Published: June 2019

Résumé Adossé aux concepts de personnalité de la marque et d’émotions, cet article s’attache à montrer leur incidence respective sur les principales variables de la relation à la marque, la confiance, l’attachement et l’engagement global envers la marque. Basé sur un panel conséquent de consommateurs, les traitements statistiques sont conduits selon une analyse des structures de covariance (ASC) ou une approche des moindres carrés partiels (PLS), en prenant soin de tenir compte de l’erreur de mesure. Le modèle correspondant valide l’incidence des émotions et de la personnalité de la marque sur l’engagement du consommateur via les effets médiateurs de la confiance et de l’attachement à la marque. Plus précisément, les résultats montrent la médiation totale de la confiance au regard de l’impact de la personnalité de la marque sur l’engagement. Ils indiquent également la médiation partielle, mais centrale, exercée par l’attachement sur l’engagement. Enfin, les analyses soulignent la stabilité des résultats sur les 6 marques testées dans cette recherche. Elles illustrent cependant des différences notables entre les marques suivant leur caractère évaluatif ou hédonique.
Association of Systemic Inflammation and Fatigue in Osteoarthritis: 2007−2010 National Health and Nutrition Examination Survey
Authors: Hackney Alisha J. , Klinedinst N. Jennifer , Resnick Barbara , Johantgen Meg 
Published: June 2019

Background/Purpose: Mechanistic insight into osteoarthritis fatigue is needed as clinical management of this condition is nonspecific. Systemic inflammation is associated with fatigue in other chronic diseases. The purpose of this study was to explore the relationship between systemic inflammation and fatigue in osteoarthritis, while controlling for covariates. Method: This secondary analysis with a cross-sectional, multiyear retrospective design used data from the 2007−2010 National Health and Nutrition Examination Survey. Adults with self-reported osteoarthritis who participated in an examination at a mobile center and had no comorbidities associated with fatigue or systemic inflammation were included ( n = 296). Complex sample analysis, independent samples t tests, and χ2 tests of independence were used to explore differences between nonfatigued and fatigued adults with osteoarthritis. Adjusted hierarchical logistic regression models were used to calculate odds of fatigue as a function of two systemic inflammatory markers, C-reactive protein (CRP), and white blood cell (WBC) count. Results: Fatigued adults with osteoarthritis had significantly higher CRP levels and WBC counts compared to nonfatigued adults with osteoarthritis. In adjusted logistic regression models, increased CRP was associated with higher odds of fatigue when controlling for age, days affected by pain, depressive symptoms, sleep quantity, and body mass index (Odds ratio [ OR] = 3.38, 95% CI [1.18, 9.69]). WBC count was not associated with higher odds of fatigue when controlling for these variables ( OR = 1.10, 95% CI [0.92, 1.32]). Conclusion: Systemic inflammation may have a relationship with fatigue in osteoarthritis. Future work is necessary to replicate these findings in more robust studies.
Lyme-associated uveitis: Clinical spectrum and review of literature
Authors: Bernard Alexia , Seve Pascal , Abukhashabh Amro , Roure-Sobas Chantal , Boibieux Andre , Denis Philippe , Broussolle Christiane , Mathis Thibaud , Kodjikian Laurent 
Published: June 2019

Background: Clinical presentation of Lyme-associated uveitis is poorly described. We reported here a case series of seven patients with uveitis related to Lyme disease and a review of the literature. Methods: A retrospective study in our university hospital between 1 May 2003 and 31 July 2016 on 1006 uveitis patients and review of Pubmed library. Results: Seven patients (71.4% male, mean age = 53 (38–70)) were diagnosed with a Lyme-associated uveitis. All anatomical types of uveitis were found (four intermediate, three anterior, and three posterior uveitis); most were unilateral (n = 6; 85.7%), one granulomatous and two with synechiae. Peripheral retinal vasculitis was present in four patients. They all had a risk of exposure or extra-ophthalmological symptoms. Antibiotic and steroid treatment was rapidly effective in all patients. Four patients presented recurrences of uveitis, of whom two received a second antibiotic treatment, which is quite common in literature. Persistent or recurrence of symptoms can be explained by three hypotheses: (1) reinfection, (2) relapse of original infection, and (3) autoimmune reaction. Conclusion: Lyme-associated uveitis appears varied. Hyalitis and involvement of the posterior segment and retinal vasculitis seem to be rather frequent. Its prognosis is mainly good, even if inflammation can be resistant or recurring.
A Review of Studies Evaluating Insecticide Barrier Treatments for Mosquito Control From 1944 to 2018
Authors: Stoops Craig A , Qualls Whitney A , Nguyen Thuy-Vi T , Richards Stephanie L 
Published: June 2019

Background and Purpose: Barrier insecticide treatments have a long history in mosquito control programs but have been used more frequently in the United States in recent years for control of invasive “backyard” species (eg, Aedes albopictus) and increases in incidence of vector-borne diseases (eg, Zika). Methods: We reviewed the published literature for studies investigating barrier treatments for mosquito control during the last 74 years (1944-2018). We searched databases such as PubMed, Web of Science, and Google Scholar to retrieve worldwide literature on barrier treatments. Results: Forty-four studies that evaluated 20 active ingredients (AIs) and 21 formulated products against multiple mosquito species are included. Insecticides investigated for efficacy included organochlorines (dichlorodiphenyltrichloroethane [DDT], β-hexachlorocyclohexane [BHC]), organophosphates (malathion), and pyrethroids (bifenthrin, deltamethrin, permethrin, lambda-cyhalothrin) as AIs. Study design varied with multiple methods used to evaluate effectiveness of barrier treatments. Barrier treatments were effective at lowering mosquito populations although there was variation between studies and for different mosquito species. Factors other than AI, such as exposure to rainfall and application equipment used, also influenced control efficacy. Conclusions: Many of the basic questions on the effectiveness of barrier insecticide applications have been answered, but several important details still must be investigated to improve precision and impact on vector-borne pathogen transmission. Recommendations are made to assist future evaluations of barrier treatments for mosquito control and to limit the potential development of insecticide resistance.
The efficacy of adding budesonide/formoterol to ipratropium plus theophylline in managing severe chronic obstructive pulmonary disease: an open-label, randomized study in China
Authors: Huang Kewu , Guo Yanfei , Kang Jian , An Li , Zheng Zeguang , Ma Lijun , Peng Liping , Wang Hongyang , Su Rong , Itoh Yohji , Wang Chen 
Published: June 2019

Background: Patients diagnosed with chronic obstructive pulmonary disease (COPD) in China are commonly prescribed ipratropium plus theophylline (I+T) therapy. Studies have shown that an inhaled corticosteroid (ICS)/long-acting β2-agonist (LABA) combination is also efficacious in reducing symptoms and exacerbations. This study evaluated the efficacy and tolerability of adding budesonide/formoterol (BUD/FORM) to I+T in Chinese patients with severe COPD. Methods: A randomized, parallel-group, open-label, multicenter phase IV study (Clinical Trials.gov identifier: NCT01415518) was conducted in China. Patients received either BUD/FORM (160/4.5 µg; two inhalations twice daily [bid] via Turbuhaler®) + I (20 µg per inhalation, two inhalations four times daily) + T (100 mg bid) or I+T alone for 12 weeks. The primary efficacy variable was change from baseline in predose forced expiratory volume in 1 s (FEV1). Results: A total of 584 patients were randomized equally between treatment groups. At the end of the study, the BUD/FORM plus I+T group displayed significant improvements in predose FEV1 versus the I+T group (between-group difference 6.9%; 95% confidence interval [CI]: 4.3, 9.6; p < 0.0001). Forced vital capacity, inspiratory capacity, peak expiratory flow and health-related quality of life (HRQoL) scores were significantly improved (all p < 0.0001) and exacerbation frequency was reduced (43.5% reduction; rate ratio 0.565, 95% CI 0.325, 0.981; p = 0.0425) with BUD/FORM plus I+T versus I+T alone. Conclusion: Patients with severe COPD in China treated with BUD/FORM plus I+T showed significant improvements in lung function and HRQoL and a reduction in exacerbations compared with I+T alone. Both treatments were well tolerated and no safety concerns were noted. The reviews of this paper are available via the supplemental material section.