bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sentinel Lymph Node Biopsy in Early Breast Cancer: Magnetic Tracer as the Only Localizing Agent
Authors: Man Vivian , Wong Ting Ting , Co Michael , Suen Dacita , Kwong Ava 
Published: April 2019

AbstractBackgroundThe combined use of radioisotope and blue dye is the gold standard in sentinel lymph node (SLN) localization in early breast cancer. Superparamagnetic iron oxide (SPIO) has recently emerged as a non‐inferior new tracer in sentinel lymph node mapping with fewer disadvantages. This study represents the first and the largest cohort of superparamagnetic iron oxide application in Asian population.MethodsRetrospective analysis of a prospectively maintained database was performed from August 2016 to December 2017. All patients with SLN localization by SPIO were included in this study.ResultsA total of 328 breast cancer patients with 333 SLNB procedures were included in this study. Median age was 54 years (range 32–86). Median tumor size was 1.9 cm (range 0.1–12 cm).There were 138 breast‐conserving surgeries and 195 mastectomies. All patients received injection of SPIO 1 day prior to operation. A total of 329 successful sentinel lymph node biopsy (SLNB) procedures were undertaken with 1514 sentinel lymph nodes (SLNs) identified. One hundred and fifty‐three (10.1%) of the SLNs were positive for malignancy. There were 54 patients with macrometastases, 26 with micrometastases and 24 with isolated tumor cells. Sixty‐seven patients underwent subsequent axillary dissection. Four patients failed sentinel lymph node identification with SPIO. The success rate of SPIO in sentinel lymph node localization was 98.8%.ConclusionSPIO represents a feasible alternative in sentinel lymph node mapping with comparably high nodal detection rate.
Risk Factors for Violent Dissident Republican Incidents in Belfast: A Comparison of Bombings and Bomb Hoaxes
Authors: Marchment Zoe , Gill Paul , Morrison John 
Published: April 2019

Abstract

Objectives
To identify risk factors for bombings and bomb hoaxes committed by dissident Republicans in Belfast, Northern Ireland.

Methods
Risk terrain modelling (RTM) was applied to each type of incident to identify significant risk layers.

Results
Previous protests and riots [relative risk value (RRV) of 14.07; spatial influence (SI) of 100 m], punishment attacks (RRV 6.56; SI 300 m) and areas dense with pubs and bars (RRV 4.98; SI 200 m) were identified as risk factors for bombings. Punishment attacks (RRV 10.77; SI 100 m), police stations (RRV 8.76; SI of 200 m) and places dense with shops (RRV 6.94; SI 400 m) were identified as risk factors for bomb hoaxes. Descriptive statistics regarding predictive accuracy concluded that half of incidents for both types occurred in high or very high risk cells in a 3-year post-study period.

Conclusions
RTM could be a useful tool in guiding targeted responses to the dissident Republican threat in Belfast. The results suggest that there is some assessment of risk by the offenders, and that they are selecting targets rationally. Due to the differences in risk factors for the two types of events it can be proposed that there may be differences between targets relevant to ideology and realistic targets with increased chance of success.
One-dimensional drift-flux correlations for two-phase flow in medium-size channels
Authors: Hibiki Takashi 
Published: April 2019

AbstractThe drift-flux parameters such as distribution parameter and drift velocity are critical parameters in the one-dimensional two-fluid model used in nuclear thermal-hydraulic system analysis codes. These parameters affect the drag force acting on the gas phase. The accurate prediction of the drift-flux parameters is indispensable to the accurate prediction of the void fraction. Because of this, the current paper conducted a state-of-the-art review on one-dimensional drift-flux correlations for various flow channel geometries and flow orientations. The essential conclusions were: (1) a channel geometry affected the distribution parameter, (2) a boundary condition (adiabatic or diabatic) affected the distribution parameter in a bubbly flow, (3) the drift velocity for a horizontal channel could be approximated to be zero, and (4) the distribution parameter developed for a circular channel was not a good approximation to calculate the distribution parameter for a sub-channel of the rod bundle. In addition to the above, the review covered a newly proposed concept of the two-group drift-flux model to provide the constitutive equation to close the modified gas mixture momentum equation of the two-fluid model mathematically. The review was also extended to the existing drift-flux correlations applicable to a full range of void fraction (Chexel-Lellouche correlation and Bhagwat-Ghajar correlation).
Aspects of the reproductive biology of the blue shark Prionace glauca (Linnaeus, 1758) in the coastal waters of Ivory Coast, West Africa
Authors: Kouamé Kouassi Yves Narcisse , Konan Kouadio Justin , Ouattara Nahoua Issa , Koné Tidiani 
Published: April 2019

AbstractThe blue shark Prionace glauca is the most abundant species in the artisanal driftnet fishery off the coastal waters of Ivory Coast. The reproductive parameters were investigated with the aim of providing basic information on the reproductive biology for fisheries management. A total of 424 specimens (256 males and 168 females) ranging from 170–330 cm in total length (TL) were sampled between August 2014 and November 2016. Sample for embryonic sex ratio was obtained from 18 litters of 503 individuals (255 males and 248 females). The embryonic sex ratio was not significantly different from 1:1 (χ2 = 0.10, P &gt; 0.05, N = 503). The size at 50% maturity (L50) was 218.1 cm TL for males and 223.3 cm TL for females. The litter size based on the number of embryos varied from 6 to 62, with an average of 30 embryos. Mating started in July whereas ovulation, fertilization and uterine eggs occurred in late October–November. Smallest embryos of 3–5 cm in stretch total length (STL) appeared in uterus from November to January. The embryo size varied widely among months, and well-pigmented embryos were already present in April–May samples, although most of them occurred in August–September, suggesting a gestation period of around 11 months. The absence of neonates in catches, as well as parturition females, does not support a hypothesis that parturition takes place in the Gulf of Guinea.
Market food diversity mitigates the effect of environment on women’s dietary diversity in the Agriculture to Nutrition (ATONU) study, Ethiopia
Authors: Ambikapathi Ramya , Gunaratna Nilupa S , Madzorera Isabel , Passarelli Simone , Canavan Chelsey R , Noor Ramadhani A , Madzivhandila Tshilidzi , Sibanda Simbarashe , Abdelmenan Semira , Tadesse Amare Worku , Berhane Yemane , Sibanda Lindiwe Majele , Fawzi Wafaie W 
Published: April 2019

AbstractObjectiveIn Ethiopia, women’s dietary diversity is low, primarily due to poor food availability and access, both at home and market level. The present study aimed to describe market access using a new definition called market food diversity (MFD) and estimate the impact of MFD, crop and livestock diversity on dietary diversity among women enrolled in the Agriculture to Nutrition (ATONU) trial.DesignBaseline cross-sectional data collected from November 2016 to January 2017 were used for the analysis. Availability of foods in markets was assessed at the village level and categorized into nine food groups similar to the dietary diversity index for women. Bivariate and multivariate mixed-effects regression analyses were conducted, adjusted for clustering at the village level.SettingChicken-producing farmers in rural Ethiopia.ParticipantsWomen (n 2117) aged 15–49 years.ResultsOverall, less than 6 % of women met the minimum dietary diversity (≥5 food groups) and the most commonly consumed food groups were staples and legumes. Median MFD was 4 food groups (interquartile range: 2–8). Multivariate models indicated that women’s dietary diversity differed by livestock diversity, food crop diversity and agroecology, with significant interaction effects between agroecology and MFD.ConclusionsWomen’s dietary diversity is poor in Ethiopia. Local markets are variable in food availability across seasons and agroecological zones. The MFD indicator captures this variability, and women who have access to higher MFD in the highland agroecological zone have better dietary diversity. Thus, MFD has the potential to mitigate the effects of environment on women’s dietary diversity.
The resolution process and the timing of settlement of medical malpractice claims
Authors: Bielen Samantha , Grajzl Peter , Marneffe Wim 
Published: April 2019

AbstractWe draw on uniquely detailed micro-level data from a Belgian professional medical liability insurer to examine how different procedural and legal events that take place during the unfolding of a medical malpractice claim influence the timing of its settlement. Utilizing the competing risks regression framework, we find that settlement hazard is all else equal statistically significantly positively associated with the completion of those procedural and legal events that most effectively reveal factual information about the underlying medical malpractice case. Consistent with theory, settlement hazard is either unassociated or even negatively associated with the completion of other procedural and legal events. Our analysis, therefore, provides policy insights into which aspects of the resolution process could be emphasized, and which de-emphasized, in order to reduce the often excessive duration of medical malpractice claims and its adverse effects on the healthcare system.
Cyber operations and the Second Geneva Convention
Authors: Biller Jeffrey 
Published: April 2019

AbstractThe recently released updated ICRC Commentary on the Second Geneva Convention (GC II) recognizes significant changes in both the conduct of naval conflicts and interpretations of the governing law. One such significant change is the addition of cyber operations to the conduct of naval operations. Modern vessels increasingly utilize computer networks to control critical ship systems, but discussions of how potential cyber operations should be viewed under GC II are understandably limited. This article aids in addressing that gap by analyzing how cyber operations could have implications for certain provisions of GC II.
Seasonal and Interannual Variations of Sea Temperature Influenced by Galápagos Islands in Eastern Tropical Pacific Ocean
Authors: Chen Yue , Lu Youyu , Zhao Peng , Xu Fanghua , Huang Xing , Huang Xiaomeng 
Published: April 2019

AbstractThe sea surface temperature and surface currents during 1993–2016 based on satellite remote sensing, along with the ocean temperature and currents during 1993–2013 from a data assimilative ocean simulation product, are analyzed to investigate the influence of the Galápagos Islands (GI) in the eastern tropical Pacific on the sea surface temperature. Variations of the cold core west of the GI are quantified by TC − TW, TC − TE, and the cold core area (CCA), where TW, TC, and TE are the sea surface temperature to the west of the cold core, in the cold core, and to the east of the GI, respectively. TC − TE and the CCA show a stronger influence of the GI in boreal fall than in spring, in contrast to TC − TW, which shows a stronger influence in spring than in fall. All three indices show weaker (stronger) GI's influence during El Niño (La Niña) years, but only CCA and TC − TE have significant correlations of −0.66 and 0.61 with the Niño3 index. Variations of TC − TW are related to that of upwelling immediately the west of the GI. Variations of TC − TE and CCA are related to that of the spatial distributions of the upper ocean temperature, the advection of temperature by the horizontal currents, specifically the north branch of the South Equatorial Current, and upwelling in the eastern tropical Pacific.
Antarctic Ice Cloud Identification and Properties Using Downwelling Spectral Radiance From 100 to 1,400 cm−1
Authors: Maestri Tiziano , Arosio Carlo , Rizzi Rolando , Palchetti Luca , Bianchini Giovanni , Del Guasta Massimo 
Published: April 2019

AbstractOne year (2013) of high spectral resolution measurements of downwelling radiance in the 100–1,400 cm−1 range, taken by the Fourier Transform Spectrometer REFIR‐PAD at the research station Concordia (Antarctic Plateau), is analyzed. Optically thin ice clouds are identified by means of a new identification/classification tool based on a Support Vector Machine algorithm. The use of transparent microwindow channels in the Far InfraRed (FIR) spectral region (100–667 cm−1) is shown to be of great importance in the identification and classification of cloud type. In particular, the channels between 380 and 575 cm−1 are key channels for the clear/cloud and phase identification due to their sensitivity to cloud properties; in addition, FIR channels down to 238 cm−1 are exploited for the selection of precipitating or nonprecipitating cases because of their sensitivity also to water vapor content. A subset of 26 cases of nonprecipitating ice clouds is selected based on the presence of colocated LIDAR and radiosonde data. REFIR‐PAD channel in the 800–1,000 cm−1 are used to derived optical and microphysical properties for four different assumptions concerning the crystal habits. Results, showing a correlation between cloud base temperature, optical depth, and particle size distribution effective dimensions, are compared with what found in literature. Based on the retrievals, forward simulations are also run over the whole sensor spectral interval, and results are compared to data. The simulation‐data residuals in the FIR are evaluated for selected “window” channels and analyzed in relation to crystal's habit assumption, cloud retrieved features, and atmospheric water vapor content.
Analysis of Lunar Boulder Tracks: Implications for Trafficability of Pyroclastic Deposits
Authors: Bickel V. T. , Honniball C. I. , Martinez S. N. , Rogaski A. , Sargeant H. M. , Bell S. K. , Czaplinski E. C. , Farrant B. E. , Harrington E. M. , Tolometti G. D. , Kring D. A. 
Published: April 2019

AbstractIn a new era of lunar exploration, pyroclastic deposits have been identified as valuable targets for resource utilization and scientific inquiry. Little is understood about the geomechanical properties and the trafficability of the surface material in these areas, which is essential for successful mission planning and execution. Past incidents with rovers highlight the importance of reliable information about surface properties for future, particularly robotic, lunar mission concepts. Characteristics of 149 boulder tracks are measured in Lunar Reconnaissance Orbiter Narrow Angle Camera images and used to derive the bearing capacity of pyroclastic deposits and, for comparison, mare and highland regions from the surface down to ~5‐m depth, as a measure of trafficability. Results are compared and complemented with bearing capacity values calculated from physical property data collected in situ during Apollo, Surveyor, and Lunokhod missions. Qualitative observations of tracks show no region‐dependent differences, further suggesting similar geomechanical properties in the regions. Generally, bearing capacity increases with depth and decreases with higher slope gradients, independent of the type of region. At depths of 0.19 to 5 m, pyroclastic materials have bearing capacities equal or higher than those of mare and highland material and, thus, may be equally trafficable at surface level. Calculated bearing capacities based on orbital observations are consistent with values derived using in situ data. Bearing capacity values are used to estimate wheel sinkage of rover concepts in pyroclastic deposits. This study's findings can be used in the context of traverse planning, rover design, and in situ extraction of lunar resources.
Lunar Cumulate Mantle Overturn: A Model Constrained by Ilmenite Rheology
Authors: Li Haoyuan , Zhang Nan , Liang Yan , Wu Bingcheng , Dygert Nicholas J. , Huang Jinshui , Parmentier E. M. 
Published: April 2019

AbstractLunar cumulate mantle overturn has been proposed to explain the abundances of TiO2 and heat‐producing elements (U, Th, and K) in the source region of lunar basalts. Ilmenite‐bearing cumulates (IBCs) that were formed near the end of lunar magma ocean solidification are the driving force for overturn. IBCs are enriched with dense TiO2 and FeO contents and have lower viscosity and solidus than those of the underlying lunar cumulate mantle. We investigate the effects of temperature‐ and ilmenite‐dependent mantle rheology on the dynamic process of lunar cumulate mantle overturn and conditions for long‐wavelength downwellings of an IBC layer in a 3‐D spherical geometry. Our results show that the ilmenite‐induced rheological weakening is necessary to decouple the IBC layer from the top stagnant lid and facilitate overturn. Models with IBC viscosity derived from the experimental scaling can only produce short‐wavelength downwellings (spherical harmonic degree >3) and show an overturn timescale more than 100 Ma. A viscosity of the IBC layer at least 10−4 lower than that of the ambient mantle can produce the long‐wavelength (spherical harmonic degree ≤3) downwellings in ~10 Ma and even a hemispheric downwelling. Such low IBC viscosity requires additional weakening mechanisms, such as remelting or/and water enrichment. During the overturn, the cold downwellings displace upward the materials from hot lower mantle and produce partial melting in upper mantle, which may serve as a viable mechanism for early lunar magmatisms. The settling of cold downwellings on the core‐mantle boundary stimulates a transient high heat flux, which may contribute to generating an early lunar dynamo event.
The Lunar Paleo‐Magnetosphere: Implications for the Accumulation of Polar Volatile Deposits
Authors: Garrick‐Bethell I. , Poppe A. R. , Fatemi S. 
Published: April 2019

AbstractAnalyses of lunar samples suggest the Moon once possessed a dynamo from ~4.25 Ga until perhaps as recently as 1 Ga, with surface field strengths between ~5 and 100 μT. While the exact timing, strength, and structure of these paleomagnetic fields are not precisely known, such relatively strong fields imply that the Moon also likely possessed a magnetosphere. Here, we present hybrid plasma simulations of the structure and morphology of the putative lunar “paleo‐magnetosphere” for varying surface field strengths and orientations, using ambient solar wind conditions representative of the early Sun. The presence of the paleo‐magnetosphere reduces total solar wind fluxes to the lunar surface overall yet, for a spin‐aligned dynamo, increases the relative solar wind flux to the lunar polar regions. In turn, the paleo‐magnetosphere may have altered the rate of volatile accretion to the Moon over its history.
Thank You to Our 2018 Peer Reviewers
Authors: Geissman John , Jolivet Laurent , Rusmore Margi , Niemi Nathan , Schildgen Taylor 
Published: April 2019

AbstractAn essential, respected, and critical aspect of the modern practice of science and scientific publishing is peer review. The process of peer review facilitates best practices in scientific conduct and communication, ensuring that manuscripts published are as accurate, valuable, and clearly communicated. The over 216 papers published in Tectonics in 2018 benefit from the time, effort, and expertise of our reviewers who have provided thoughtfully considered advice on each manuscript. This role is critical to advancing our understanding of the evolution of the continents and their margins, as these reviews lead to even clearer and higher‐quality papers. In 2018, the over 443 papers submitted to Tectonics were the beneficiaries of more than 1,010 reviews provided by 668 members of the tectonics community and related disciplines. To everyone who has volunteered their time and intellect to peer reviewing, thank you for helping Tectonics and all other AGU Publications provide the best science possible.
Exploiting the interplay between cross-sectional and longitudinal data in Class III malocclusion patients
Authors: Barelli Enrico , Ottaviani Ennio , Auconi Pietro , Caldarelli Guido , Giuntini Veronica , McNamara James A. , Franchi Lorenzo 
Published: April 2019

AbstractThe aim of the study was to investigate how to improve the forecasting of craniofacial unbalance risk during growth among patients affected by Class III malocclusion. To this purpose we used computational methodologies such as Transductive Learning (TL), Boosting (B), and Feature Engineering (FE) instead of the traditional statistical analysis based on Classification trees and logistic models. Such techniques have been applied to cephalometric data from 728 cross-sectional untreated Class III subjects (6–14 years of age) and from 91 untreated Class III subjects followed longitudinally during the growth process. A cephalometric analysis comprising 11 variables has also been performed. The subjects followed longitudinally were divided into two subgroups: favourable and unfavourable growth, in comparison with normal craniofacial growth. With respect to traditional statistical predictive analytics, TL increased the accuracy in identifying subjects at risk of unfavourable growth. TL algorithm was useful in diffusion of information from longitudinal to cross-sectional subjects. The accuracy in identifying high-risk subjects to growth worsening increased from 63% to 78%. Finally, a further increase in identification accuracy, up to 83%, was produced by FE. A ranking of important variables in identifying subjects at risk of growth worsening, therefore, has been obtained.
Organoid culture media formulated with growth factors of defined cellular activity
Authors: Urbischek Manuela , Rannikmae Helena , Foets Thomas , Ravn Katharina , Hyvönen Marko , de la Roche Marc 
Published: April 2019

AbstractThe media formulations necessary for deriving and sustaining organoids from epithelial tissues such as prostate, colon, gastric, liver, pancreas, and others have been established. Critical components of organoid media are a set of growth factors that include R-spondins and BMP signalling antagonists such as Noggin or Gremlin 1. Currently, the practical limitations for formulating organoid media of reproducible potency and larger-scale media production that have hampered further technological applications of organoid technology include: the cost of growth factors such as R-spondins and Gremlin 1/Noggin and their production as defined specific activities free of contaminants that may affect organoid growth. Here we report the production of highly pure recombinant Gremlin 1 and R-spondin 1 from bacterial expression for use in organoid media. We detail the workflow for Gremlin 1 and R-spondin 1 expression, purification, quantification of cellular activity, quality control and use in media formulated for culturing organoids derived from a number of tissues. The development of precisely formulated, cost-effective media of defined specific activity will engender the development of novel applications for organoid technology.