bluuebunny/crossref_metadata_2025_split huggingface dataset:
Active Surveillance in Patients with Extra-abdominal Desmoid-Type Fibromatosis: A Pooled Analysis of Three Prospective Observational Studies
Authors: Colombo Chiara , Hakkesteegt Stefanie , Le Cesne Axel , Barretta Francesco , Blay Jean-Yves , Grünhagen Dirk J. , Penel Nicolas , Lam Laurent , Fiore Marco , Palassini Elena , Grignani Giovanni , Tolomeo Francesco , Collini Paola , Merlini Alessandra , Perrone Federica , Stacchiotti Silvia , Verhoef Cornelis ,   for the Dutch Grafiti Group, Bonvalot Sylvie ,   for the French Sarcoma Group, Gronchi Alessandro 
Published: December 2024

Abstract

Purpose:
Three prospective observational studies (Italy, the Netherlands, and France) on active surveillance (AS) in patients with extra-abdominal desmoid-type fibromatosis support AS as a first-line approach. Identifying prognostic factors for the failure of AS will help determine the strategy. The aim of this study was to investigate the prognostic impact of clinical and molecular variables in a larger series.

Experimental Design:
Data available as of January 31, 2024, from the three studies, in which patients were followed for ≥3 years, were pooled. Patients ≥18 years of age, with primary sporadic desmoid-type fibromatosis, and with CTNNB1 mutations available were eligible. The primary study endpoint was treatment-free survival (TFS). Secondary endpoints included the incidence of RECIST progression, spontaneous RECIST regression, and regression post-RECIST progression.

Results:
Patients (n = 282) with a median follow-up of 53 months (IQR, 39–63) were included. The 3- and 5-year TFS rates were 67% and 66%, respectively; the 3- and 5-year crude cumulative incidences were 33% and 34% for RECIST progression, 26% and 34% for RECIST regression, and 33% and 38% for regression post-RECIST progression, respectively. In multivariable analysis, larger tumor size, mutation type, and tumor locations were associated with lower TFS. The specific mutation (S45F), larger tumor size, and extremity and trunk locations were all associated with a lower probability of spontaneous RECIST regression.

Conclusions:
This study confirms that spontaneous regression occurs in a significant proportion of patients and that two-thirds are treatment free at 5 years. Initial tumor size, CTNNB1 mutation, and location should be factored into the initial decision-making process.
A connectome manipulation framework for the systematic and reproducible study of structure–function relationships through simulations
Authors: Pokorny Christoph , Awile Omar , Isbister James B. , Kurban Kerem , Wolf Matthias , Reimann Michael W. 
Published: December 2024

Abstract
Synaptic connectivity at the neuronal level is characterized by highly nonrandom features. Hypotheses about their role can be developed by correlating structural metrics to functional features. But, to prove causation, manipulations of connectivity would have to be studied. However, the fine-grained scale at which nonrandom trends are expressed makes this approach challenging to pursue experimentally. Simulations of neuronal networks provide an alternative route to study arbitrarily complex manipulations in morphologically and biophysically detailed models. Here, we present Connectome-Manipulator, a Python framework for rapid connectome manipulations of large-scale network models in Scalable Open Network Architecture TemplAte (SONATA) format. In addition to creating or manipulating the connectome of a model, it provides tools to fit parameters of stochastic connectivity models against existing connectomes. This enables rapid replacement of any existing connectome with equivalent connectomes at different levels of complexity, or transplantation of connectivity features from one connectome to another, for systematic study. We employed the framework in the detailed model of the rat somatosensory cortex in two exemplary use cases: transplanting interneuron connectivity trends from electron microscopy data and creating simplified connectomes of excitatory connectivity. We ran a series of network simulations and found diverse shifts in the activity of individual neuron populations causally linked to these manipulations.
‘Grotian Moments’ in the Dutch East Indies? The Reception of Hugo Grotius’s Ideas in Cornelis Van Vollenhoven’s Writings on Customary Law and Colonialism
Authors: in ’t Veld Cornelis Marinus (Marco) 
Published: November 2024

Abstract
In this paper it is argued that Grotius views on customary law are compatible with the concept of a ‘Grotian Moment’. However, the idea of accelerated customary international law is developed by Van Vollenhoven, who interpreted Grotius in a questionable way. Whereas Grotius qualifies as a thinker in the tradition of natural law, Van Vollenhoven should be seen as an interactionist. This is especially visible in his publications on adat law, in which he visibly belongs to a romantic, Germanist, and rather pluralist tradition of law. The idea of a Grotian Moment also fits better with this starting point than with natural law. For this reason, the ‘Grotian Moment’ should be renamed ‘Van Vollenhoven’s Moment’. It is argued that this legal theoretical position explains some of Van Vollenhoven’s rather peculiar interpretations of Grotius.
Recurrent Inflammatory Reaction to Laryngeal Hyaluronic Acid Injection
Authors: Kreuser Hannah , Fletcher Kenneth C. , Davis Ruth J. 
Published: November 2024

Objectives: Vocal fold injection augmentation with hyaluronic acid (HA) fillers is a common treatment for glottic insufficiency. While generally well-tolerated, rare inflammatory reactions can occur in 3% to 5% of patients. All reported reactions resolved after corticosteroid treatment, and no cases of recurrent inflammatory reaction with airway obstruction following steroid treatment have been reported. This case report describes a unique case of recurrent inflammatory reactions following laryngeal HA injection and management with hyaluronidase injection to prevent further reactions. Methods: A retrospective review was conducted of this patient’s medical record. Results: We present the case of a 42-year-old female with left vocal fold immobility who experienced recurrent inflammatory reactions and airway symptoms following laryngeal HA injection despite corticosteroid treatment. Recurrent inflammatory reaction following corticosteroid treatment of an initial inflammatory reaction has not been reported. This patient was managed with hyaluronidase injection to dissolve residual HA, which successfully prevented further reactions. Conclusion: This case highlights the potential for recurrent inflammatory reactions following HA injection despite corticosteroid treatment and describes the novel role of hyaluronidase in managing such complications.
The Development and Clinical Impact of an Innovative Palliative Care Lever Tool for Individuals With Idiopathic Pulmonary Fibrosis: A Quality Improvement Project
Authors: Fenwick Kathryn , Kreider Maryl , Kates Jeannette 
Published: November 2024

Background Palliative care (PC) is underutilized in the idiopathic pulmonary fibrosis (IPF) patient population, particularly in outpatient settings, despite high symptom burden and complex care needs. There is no clinician consensus for the most effective method of integrating PC into routine medical visits for this patient population, despite acknowledgement of its benefits. The purpose of this quality improvement (QI) project was to pilot an adapted nurse practitioner-led standardized PC lever tool for IPF in an outpatient clinic and evaluate the secondary PC referral rates during the implementation period. Design The lever tool was implemented over a 3-month period. De-identified patient health information from the health system’s electronic medical record system was used to compare referrals to PC prior to and during the implementation of the lever tool. Results The established workflow for the nurse practitioner-led implementation of the tool was feasible. There were increased PC referrals and increased PC encounters during the QI period, however the results were not statistically significant. Conclusions The findings of this QI project add to the limited existing literature evaluating PC referral methods for individuals with IPF in an outpatient setting. Further, the development process and workflow utilized confirms the feasibility of employing the nursing workforce to support the care needs of the IPF patient population.
Impact of aspirin on the outcome of upper limb AVF placement in hemodialysis patients: Discontinuation or not
Authors: Azimi Behzad , Mozaffar Mohammad , Soleimani Sina , Mousavi Behnaz , Haghbin Toutounchi Alireza 
Published: December 2024

Background: There is limited research on the consumption of aspirin and its effects on bleeding during arteriovenous fistula (AVF) placement surgery and associated complications in end-stage renal disease (ESRD) patients. Regarding the potential risks imposed on cardiac patients by discontinuing aspirin, the aim of the study was to determine whether aspirin should be discontinued prior to AVF placement surgery. Methods: This prospective study was carried out at two referral medical centers from 2023 to 2024. The patients were included as 30 patients who routinely took 80 mg of aspirin daily and 30 patients who did not take aspirin. The primary outcomes included the amount of blood loss, and the secondary outcomes included AVF success and maturation time. The amount of bleeding was assessed by the ΔHb (Hb1−Hb2), ΔHCT (HCT1−HCT2), and intraoperative hemorrhage volume. Results: Aspirin consumption did not significantly affect any of the examined parameters, including operation duration, hemoglobin decrease, hematocrit decrease, intraoperative hemorrhage, AVF success rate, maturity time, need for blood transfusion, postoperative bleeding, hematoma and thrombosis, hospitalization, and re-Operation ( p > 0.05). Conclusion: Aspirin did not have any significant or negative effects across any of the parameters examined. Based on the findings of this study, there is no need to discontinue aspirin in patients prior to upper limb AVF placement surgery, but further studies are recommended.
Heritage Russian in contact with Hebrew and German: A cross-linguistic study of requests
Authors: Avramenko Marina , Warditz Vladislava , Meir Natalia 
Published: November 2024

Purpose: This study examined request production by heritage language (HL) speakers of Russian dominant in different societal languages (SLs), such as SL-Hebrew and SL-German. By comparing request strategies in Russian, Hebrew, and German, the study investigated the effect of cross-linguistic influence (CLI) from the SL on the HL, as well as the effect of diminished HL input. Methodology: Request production in both formal and informal contexts was compared among three groups of Russian speakers: monolingual L1-Russian speakers ( n = 26), HL-Russian speakers dominant in SL-Hebrew ( n = 26), and HL-Russian speakers dominant in SL-German ( n = 26) via an elicitation task. Data and analysis: Analysis involved comparing request production across groups using statistical methods to identify differences and similarities in strategies related to (a) address forms; (b) morphosyntactic realization, including clause type (declarative, interrogative, and imperative), the presence of the Russian negation particle “ne,” and the subjunctive particle “by”; and (c) lexical strategies. Findings: The study identified differences between HL-speakers and monolingual controls, as well as variations between the two bilingual groups. Divergence in HL-speakers was attributed to CLI and reduced input. Originality: Unlike previous studies that compare two L1s, this study focused on HLs, suggesting a new area of research due to their indeterminate status as neither L1 nor L2. The study provides additional evidence on how cross-linguistic factors impact pragmatic development in HL-speakers, contributing to understanding bilingual communication and language acquisition processes. Significance: To the best of our knowledge, this is the first study to date that compared requests in HL-speakers of typologically different SLs.
Prescription for change: Unveiling burnout perspectives among pharmacy leaders
Authors: Kiriazopoulos Stefanie , Perepelkin Jason , Alford Heather 
Published: November 2024

Background: Burnout among pharmacists is increasingly pertinent, with growing demand for effective interventions. Burnout can lead to reduced productivity, increased job turnover, medical errors, poor patient satisfaction, and other negative outcomes for patients and providers. Growing attention to burnout in the pharmacy profession highlights the need for personal, organizational, and systemic solutions. However, the uptake and relative efficacy of different approaches remain unclear, particularly within community pharmacy practice. This study sought the viewpoint of community pharmacy leaders (i.e., community pharmacy managers, district managers, franchisees, owners, and executives from various pharmacy organizations) to characterize burnout from their perspectives. Methods: This qualitative study followed a grounded theory approach. Community pharmacy leaders were interviewed using a semistructured format to gather in-depth insights into their experiences and perspectives on burnout and engagement. Results: Sixteen people were interviewed; interviews lasted 30 to 65 minutes, averaging 51 minutes long. Six themes were identified: perceived disconnection between front-line staff and pharmacy decision-makers, overwhelming work demands, cautious optimism toward the expanding scope of pharmacy practice, the importance of employee recognition and appreciation, appropriateness and use of existing work resources, and multimodal, systemic responsibility and solutions to burnout. Conclusion: Addressing burnout requires a multifaceted approach involving personal, organizational, and systemic interventions. Evidence from this study provides valuable insights into the feasibility and efficacy of specific interventions, informing future strategies to enhance workplace well-being and engagement. The study highlights the importance of managing job demands and maximizing resources, emphasizing that personal approaches alone are insufficient and that organizational and systemic interventions are crucial.
White matter hyperintensities are independently associated with systemic vascular aging and cerebrovascular dysfunction
Authors: Webb Alastair JS , Feakins Karolina , Lawson Amy , Stewart Catriona , Thomas James , Llwyd Osian 
Published: November 2024

Background: In the Oxford Haemodynamic Adaptation to Reduce Pulsatility trial (OxHARP), sildenafil increased cerebrovascular reactivity but did not reduce cerebral pulsatility, a marker of vascular aging. This analysis of OxHARP tested whether these potentially causative mechanisms were independently associated with the severity of white matter hyperintensities (WMHs). Aims: The aims were to determine independence of the relationship between severity of WMHs with both cerebral pulsatility and cerebrovascular reactivity in the same population. Methods: OxHARP was a double-blind, randomized, placebo-controlled, crossover trial of phosphodiesterase inhibitors in patients with mild-to-moderate WMH and previous minor cerebrovascular events. It determined effects on cerebrovascular pulsatility and reactivity on transcranial ultrasound and reactivity on magnetic resonance imaging (MRI). Associations were determined between baseline ultrasound measures, and averaged MRI measures across follow-up, with the severity of WMH on clinical imaging (Fazekas or modified Blennow scores) and WMH volume in the MRI substudy, by ordinal and linear regression. Results: In 75/75 patients (median 70 years, 78% male), cerebral pulsatility was associated with age (p < 0.001) whereas reactivity on ultrasound was not (p = 0.29). Severity of WMH in all participants was independently associated with decreased cerebrovascular reactivity and increased cerebral pulsatility (pulsatility p = 0.016; reactivity p = 0.03), with a trend to a synergistic interaction (p = 0.075). Reactivity on ultrasound was still associated with WMH after further adjustment for age (p = 0.017), but pulsatility was not (p = 0.31). Volume of WMH in the MRI substudy was also independently associated with both markers on ultrasound (pulsatility p = 0.005; reactivity p = 0.029) and was associated with reduced cerebrovascular reactivity within WMH on MRI (p < 0.0001). Conclusion: WMHs are independently associated with cerebral pulsatility and reactivity, representing complementary potential disease mechanisms and treatment targets. Trial Registration: clinicaltrials.org: https://classic.clinicaltrials.gov/ct2/show/NCT03855332 .
Ginsenoside Rb1 affects mitochondrial Ca2+ transport and inhibits fat deposition and fibrosis by regulating the wnt signaling pathway to treat rotator cuff tears via docking with SFRP1
Authors: Yin Yuesong , Hu Hai , Yang Yian , Wu Song 
Published: December 2024

Abstract
Background
Rotator cuff tears (RCTs) are among the most common musculoskeletal disorders that affect quality of life. This study aimed to investigate the efficacy of ginsenoside Rb1 in RCTs and the mechanisms involved.

Methods
First, a fibrotic model of FAPs was induced, and FAPs were cultured in media supplemented with different concentrations of ginsenoside Rb1. Next, a rat model of RCTs was constructed and treated with ginsenoside Rb1. Molecular docking was subsequently utilized to detect the binding of ginsenoside Rb1 and SFRP1. Finally, SFRP1 was knocked down and overexpressed in vivo and in vitro to investigate the mechanism of ginsenoside Rb1 and SFRP1 in RCTs.

Results
Compared with the Normal group, FAP viability was decreased, but Collagen II, FN and α-SMA levels were increased in the Control group. After treatment with different concentrations of ginsenoside Rb1, FAP viability increased, but Collagen II, FN and α-SMA levels decreased. Among them, 60 µM ginsenoside Rb1 had the best effect. In vivo experiments revealed that ginsenoside Rb1 improved RCTs in rats. Molecular docking revealed the binding of ginsenoside Rb1 to SFRP1. Additionally, SFRP1 levels were lower in the Control group than in the Normal group. After treatment with ginsenoside Rb1, SFRP1 levels increased. In vivo, overexpressing SFRP1 along with ginsenoside Rb1 treatment further alleviated tendon tissue fibroblast infiltration and fat accumulation and further reduced the expression of Collagen II, FN, and α-SMA. In vitro, overexpressing SFRP1 along with ginsenoside Rb1 treatment further decreased the expression of CaMKII, PLC, PKC, Wnt, and β-catenin, further decreased the Ca2+ fluorescence intensity and mitochondrial length, increased the red/green intensity, and decreased the MitoSOX fluorescence intensity. Additionally, overexpressing SFRP1 along with ginsenoside Rb1 treatment further increased cell proliferation, decreased apoptosis, reduced the protein expression of Collagen II, FN, and α-SMA in muscle tissue, and further reduced the levels of TNF-α, IL-1β, and IL-6 in the cell supernatant.

Conclusions
Ginsenoside Rb1 inhibited the activation of the Wnt signaling pathway by promoting SFRP1 expression, thereby inhibiting mitochondrial function and Ca2+ absorption to treat fat infiltration and muscle fibrosis caused by RCTs.
The cLVSM: A Novel Compact Linear Variable Stiffness Mechanism Based on Circular Beams
Authors: Shao Yixin , Zhou Yufeng , Shi Di , Feng Yanggang , Ding Xilun , Zhang Wuxiang 
Published: December 2024

AbstractVariable stiffness mechanisms (VSMs) are a class of compliant mechanisms that can adjust their intrinsic stiffness, which promises to be beneficial in applications needed to interact with the environment, such as collaborative robots, wearable robots, and polishing robots. This paper presents the design and optimization of a novel linear VSM, called cLVSM, to produce linear motion, conversely to the majority of VSMs designed to perform rotary motion. By changing the effective length of specially designed circular beams, the cLVSM is capable of continuous stiffness regulation from a minimum value to almost rigid. Different from the VSMs which need rotation-to-translation converting mechanisms for stiffness regulation, the stiffness of the proposed design is adjusted by directly rotating the beams without the use of additional mechanisms, which contributes to improving the structural compactness, and reducing the energy loss and error in transmission. Moreover, the beam rotation needed to regulate the stiffness is almost perpendicular to the beam deflection force, which helps to reduce the torque needed for stiffness regulation. The stiffness model of the proposed VSM is developed using the screw theory, and the design parameters are optimized using the genetic algorithm. The effectiveness of the mathematical model and the performance of the design are verified by simulation and experiments.
Automatic measurement of choroidal thickness with swept-source optical coherence tomography in chronic Vogt-Koyanagi-Harada disease: 3 years’ follow-up
Authors: Yamamoto-Rodríguez Liria , Anduaga-Beramendi Alexander , Mediavilla-Vallespín Roger , Subirà Olaia , Garcia-Bru Pere , Solanich-Moreno Xavier , Arias Luis , Caminal Josep M. , García-García Olga 
Published: December 2024

Abstract
Purpose
The course of Vogt-Koyanagi-Harada (VKH) disease is typically assessed qualitatively using indocyanine green angiography (ICGA) and enhanced-depth imaging optical coherence tomography (EDI-OCT). However, a quantitative approach could improve accuracy and objectivity. The aim of this study was to assess the clinical value of the automated measurement capabilities of swept-source optical coherence tomography (SS-OCT) to measure choroidal thickness (quantitative approach) in chronic VKH.

Methods
Prospective, longitudinal case–control study at a tertiary university hospital involving 23 chronic VKH patients (9 convalescent and 14 quiescent) and 17 age-matched controls. Choroidal thickness was automatically measured with SS-OCT.

Results
Choroidal thinning and improved vision were associated with treatment while increasing thickness and worsening vision were associated with posterior relapse. Overall, 41.6% of asymptomatic (no change in visual acuity) recurrences in the convalescent group and 25% of recurrences in the quiescent group were detected by SS-OCT. All recurrences diagnosed by SS-OCT showed signs of inflammation on ICGA.

Conclusions
Automatic measurement of choroidal thickness with SS-OCT is a rapid, non-invasive method of detecting posterior segment recurrences and treatment response in VKH patients, and could reduce the need for angiography to monitor this disease.