bluuebunny/crossref_metadata_2025_split huggingface dataset:
Two Contrasting Patterns and Underlying Genes for Coadaptation of Seed Dormancy and Flowering Time in Rice
Authors: Gu Xing-You , Pipatpongpinyo Wirat , Zhang Lihua , Zhou Yuliang , Ye Heng , Feng Jiuhuan 
Published: November 2018

AbstractAssociation between seed dormancy (SD) and flowering time (FT) may generate a synergy in plant adaptation. This research aimed to identify patterns and underlying genes of the association in rice (Oryza sativa). Four F2 and two BC1F1 populations from crosses of weedy/cultivated rice, and two families of progeny lines from backcrosses were evaluated for variations in time to flowering and germination ability. The two measurements were correlated negatively in the F2 and BC1F1 populations, but positively in advanced generations of the progeny lines. The negative correlations were resulted from linkage disequilibria between SD and FT loci at 7–40 cM apart. The positive correlations arose from co-located SD and FT loci undetectable in the BC1F1 population. Two independent sets of co-localized loci were isolated as single Mendelian factors, and haplotypes that promote flowering and reduce germination derived from weedy and cultivated rice, respectively. The presence of negative and positive correlations indicates that the rice complex has maintained two contrasting patterns of SD-FT coadaptation, with the positive being “recessive” to the negative pattern. Modeling with isogenic lines suggests that a negative pattern could generate a greater synergy (difference between haplotype variants) than the positive one for seedbank persistence, or enhanced plant adaptation to seasonal changes in temperature or moisture. However, the early-flowering dormant genotype of a positive pattern could also have a selective advantage over its counterpart for weeds to avoid harvesting. The isolated haplotypes could be used to manipulate cultivars simultaneously for germination ability and growth duration.
Regional variations in human milk oligosaccharides in Vietnam suggest FucTx activity besides FucT2 and FucT3
Authors: van Leeuwen Sander S. , Stoutjesdijk Eline , ten Kate Geert A. , Schaafsma Anne , Dijck-Brouwer Janneke , Muskiet Frits A. J. , Dijkhuizen Lubbert 
Published: November 2018

AbstractBreastfeeding is the normal way of providing young infants with the nutrients they need for healthy growth and development (WHO). Human milk oligosaccharides (hMOS) constitute a highly important class of nutrients that are attracting strong attention in recent years. Several studies have indicated that hMOS have prebiotic properties, but also are effective in anti-adhesion of pathogens, modulating the immune system and providing nutrients for brain growth and development. Most of the latter functions seem to be linked to the presence of fucose-containing immunodeterminant epitopes, and Neu5Ac-bearing oligosaccharides. Analysis of hMOS isolated from 101 mothers’ milk showed regional variation in Lewis- and Secretor based immunodeterminants. Lewis-negative milk groups could be sub-divided into two sub-groups, based on the activity of a third and hitherto unidentified fucosyltransferase enzyme. Analysis of hMOS remaining in faeces showed three sub-groups based on hMOS surviving passage through the gut, full consumption, specific partial consumption and non-specific partial consumption, fitting previous findings.
The anti-tumor diterpene oridonin is a direct inhibitor of Nucleolin in cancer cells
Authors: Vasaturo Michele , Cotugno Roberta , Fiengo Lorenzo , Vinegoni Claudio , Dal Piaz Fabrizio , De Tommasi Nunziatina 
Published: November 2018

AbstractThe bioactive plant diterpene oridonin displays important pharmacological activities and is widely used in traditional Chinese medicine; however, its molecular mechanism of action is still incompletely described. In vitro and in vivo data have demonstrated anti-tumor activity of oridonin and its ability to interfere with several cell pathways; however, presently only the molecular chaperone HSP70 has been identified as a direct potential target of this compound. Here, using a combination of different proteomic approaches, innovative Cellular Thermal Shift Assay (CETSA) experiments, and classical biochemical methods, we demonstrate that oridonin interacts with Nucleolin, effectively modulating the activity of this multifunctional protein. The ability of oridonin to target Nucleolin and/or HSP70 could account for the bioactivity profile of this plant diterpene. Recently, Nucleolin has attracted attention as a druggable target, as its diverse functions are implicated in pathological processes such as cancer, inflammation, and viral infection. However, up to now, no small molecule as Nucleolin binders has been reported, thus our finding represents the first evidence of Nucleolin modulation by a small inhibitor.
Statin-induced metabolic reprogramming in head and neck cancer: a biomarker for targeting monocarboxylate transporters
Authors: Mehibel Manal , Ortiz-Martinez Fernando , Voelxen Nadine , Boyers Amy , Chadwick Amy , Telfer Brian A. , Mueller-Klieser Wolfgang , West Catharine M. , Critchlow Susan E. , Williams Kaye J. , Stratford Ian J. 
Published: November 2018

AbstractPrognosis of HPV negative head and neck squamous cell carcinoma (HNSCC) patients remains poor despite surgical and medical advances and inadequacy of predictive and prognostic biomarkers in this type of cancer highlights one of the challenges to successful therapy. Statins, widely used for the treatment of hyperlipidaemia, have been shown to possess anti-tumour effects which were partly attributed to their ability to interfere with metabolic pathways essential in the survival of cancer cells. Here, we have investigated the effect of statins on the metabolic modulation of HNSCC cancers with a vision to predict a personalised anticancer therapy. Although, treatment of tumour-bearing mice with simvastatin did not affect tumour growth, pre-treatment for 2 weeks prior to tumour injection, inhibited tumour growth resulting in strongly increased survival. This was associated with increased expression of the monocarboxylate transporter 1 (MCT1) and a significant reduction in tumour lactate content, suggesting a possible reliance of these tumours on oxidative phosphorylation for survival. Since MCT1 is responsible for the uptake of mitochondrial fuels into the cells, we reasoned that inhibiting it would be beneficial. Interestingly, combination of simvastatin with AZD3965 (MCT1 inhibitor) led to further tumour growth delay as compared to monotherapies, without signs of toxicity. In clinical biopsies, prediagnostic statin therapy was associated with a significantly higher MCT1 expression and was not of prognostic value following conventional chemo-radiotherapy. These findings provide a rationale to investigate the clinical effectiveness of MCT1 inhibition in patients with HNSCC who have been taking lipophilic statins prior to diagnosis.
Establishment of a Regional Interdisciplinary Medical System for Managing Patients with Tuberous Sclerosis Complex (TSC)
Authors: Fujimoto Ayataka , Okanishi Tohru , Imai Shin , Ogai Masaaki , Fukunaga Akiko , Nakamura Hidenori , Sato Keishiro , Obana Akira , Masui Takayuki , Arai Yoshifumi , Enoki Hideo 
Published: November 2018

AbstractTuberous sclerosis complex (TSC) is an autosomal dominant inherited disease characterized by lesions that involve multiple organs. Interdisciplinary management at individual facilities needs to be coordinated to treat multiple organ systems. We hypothesized that the number of patients, opportunities for patients to undergo examinations, and opportunities for patients to be treated would increase after establishment of a TSC board (TB) in our hospital. From August 1979 to August 2017, 76 patients were studied. We established the TB in our hospital in 2014. We divided the patients into the pre-TB group and post-TB group. Patients consisted of 33 females and 43 males (mean age, 18.7 years; median age, 15 years). The follow-up period was 2 to 457 months (mean, 51.6 months; median, 24.5 months). Twenty-four patients were in the pre-TB group, and 52 were in the post-TB group. Regular follow-up (p < 0.001), younger age (p = 0.002), opportunities for patients to undergo examinations, opportunities for patients to receive neurological treatment (p < 0.001), and mammalian target of rapamycin (mTOR) inhibitor usage (p = 0.041) were significantly higher in the post-TB group. The radial relationship around the axis of TSC coordinators may be the key to interdisciplinary management of TSC.
Administration of hydrogen-rich water prevents vascular aging of the aorta in LDL receptor-deficient mice
Authors: Iketani Masumi , Sekimoto Kanako , Igarashi Tsutomu , Takahashi Mayumi , Komatsu Masaki , Sakane Iwao , Takahashi Hiroshi , Kawaguchi Hideo , Ohtani-Kaneko Ritsuko , Ohsawa Ikuroh 
Published: November 2018

AbstractThe main cause of arteriosclerosis is atherosclerosis in the aorta. Atherosclerosis is recognized as a chronic inflammatory condition that begins with the dysfunction or activation of arterial endothelium. Low-density lipoprotein (LDL) and especially its oxidized form play a key role in endothelial dysfunction and atherogenesis. Recent studies showed that senescent cells are involved in the development and progression of atherosclerosis, and eliminating senescent cells suppresses the senescence-associated secretory phenotype. We previously reported that molecular hydrogen-rich water (HW) has antioxidant and anti-inflammatory effects in numerous diseases. Here, we used LDL receptor-deficient mice fed a high-fat diet (HFD) for 13 weeks as a model for atherosclerosis and evaluated the effects of continuous administration of HW. The numbers of endothelial cells in the atheroma expressing the senescence factors p16INK4a and p21 decreased in HFD-fed mice given HW compared with HFD-fed mice given control water. Furthermore, macrophage infiltration and Tnfα expression in the atheroma were also suppressed. These results suggest that vascular aging can be suppressed by HW.
Nucleation and growth of TiAl3 intermetallic phase in diffusion bonded Ti/Al Metal Intermetallic Laminate
Authors: Thiyaneshwaran N. , Sivaprasad K. , Ravisankar B. 
Published: November 2018

AbstractA novel nucleation and growth phenomenon for TiAl3 intermetallic phase in Ti/Al diffusion couple is proposed based on diffusion kinetics. The interdiffusion and intrinsic diffusion co-efficients are calculated to make evident of dominant diffusion of Al towards Ti in Ti/Al diffusion couple obtained by solid state diffusion bonding. It was surprising to observe that the diffusion rate of Al was around 20 times higher than Ti with the formation of Kirkendall pores near the Al/TiAl3 interface. With such dominant diffusion of Al towards Ti, the nucleation and growth of TiAl3 intermetallic phase in Ti/Al couple happens mainly at the Ti/TiAl3 interface rather than Al/TiAl3 interface which is evident by the presence of very fine nearly nano-sized TiAl3 nuclei/grains near the Ti/TiAl3 interface. Even though the intermetallic phase is expected to nucleate at Al/TiAl3 interface, the relatively larger TiAl3 grains near that interface depicts grain growth with minimal nucleation. The theoretical calculations on diffusion parameters are in accordance with experimental observations of TiAl3 intermetallic growth phenomenon in Ti/Al system.
Vocal Biomarkers of Mild-to-Moderate Hearing Loss in Children and Adults: Voiceless Sibilants
Authors: Pittman Andrea L. , Daliri Ayoub , Meadows Lauren 
Published: November 2018

Purpose
The purpose of this study was to determine if an objective measure of speech production could serve as a vocal biomarker for the effects of high-frequency hearing loss on speech perception. It was hypothesized that production of voiceless sibilants is governed sufficiently by auditory feedback that high-frequency hearing loss results in subtle but significant shifts in the spectral characteristics of these sibilants.

Method
Sibilant production was examined in individuals with mild to moderately severe congenital (22 children; 8–17 years old) and acquired (23 adults; 55–80 years old) hearing losses. Measures of hearing level (pure-tone average thresholds at 4 and 8 kHz), speech perception (detection of nonsense words within sentences), and speech production (spectral center of gravity [COG] for /s/ and /ʃ/) were obtained in unaided and aided conditions.

Results
For both children and adults, detection of nonsense words increased significantly as hearing thresholds improved. Spectral COG for /ʃ/ was unaffected by hearing loss in both listening conditions, whereas the spectral COG for /s/ significantly decreased as high-frequency hearing loss increased. The distance in spectral COG between /s/ and /ʃ/ decreased significantly with increasing hearing level. COG distance significantly predicted nonsense-word detection in children but not in adults.

Conclusions
At least one aspect of speech production (voiceless sibilants) is measurably affected by high-frequency hearing loss and is related to speech perception in children. Speech production did not predict speech perception in adults, suggesting a more complex relationship between auditory feedback and feedforward mechanisms with age. Even so, these results suggest that this vocal biomarker may be useful for identifying the presence of high-frequency hearing loss in adults and children and for predicting the impact of hearing loss in children.
Investigation of the phase structure and surface morphology of the titanium nano-structured coatings for dental implants deposited by the method of magnetron sputtering
Authors: Gevorgyan Vladimir A. , Dolgalev Alexander A. , Tarala Vitaliy A. , Mangasaryan Naira R. , Buchalov Boris V. 
Published: November 2018

In this work we develop a technology for deposition of titanium nano-structured coatings on titanium plain washers by magnetron sputtering and investigate the influence of technological conditions on the structural parameters of the deposited titanium coatings. Magnetron sputtering of pure 99.99% titanium coatings on titanium washers VT1.0 and VT6.0, has been developed. It is shown that by this method it is possible to form coatings of pure titanium with a nano-relief surface. Titanium coatings under varying deposition parameters were characterized by Scanning Electron Microscopy and Atom Force Microscopy. It is shown that titanium coatings deposited by magnetron sputtering technique have a nano-granular structure. The maximum surface irregularities vary within ± 150 nm, and the grain sizes vary from 50 nm to 450 nm. The obtained result is of great interest for further investigation of the influence of titanium coatings morphology and its nano-dimensional characteristics on the biochemical mechanisms responsible for the process of bone remodeling around the implant.
It is established that titanium coatings allow not only to form on the implants a nano-relief surface, but also drastically reduce on this surface the concentration of toxic elements that are initially present in the implant material VT6.0.
Measuring of plasma’s velocity in electrodynamic railgun using high-frequency method
Authors: Kirievskiy Vladimir V. , Kirievskiy Evgeny V. 
Published: November 2018

A method is proposed for measuring the velocity of a moving plasma in an electrodynamic railgun in the part of internal ballistics. The achieved result is to provide a measurement of instantaneous velocity and an increase of the safety level for operation of measuring devices.
The method is based on the excitation of the rail system of railgun high frequency electric oscillations during in due motion of plasma and creates current resonance. Then is continuously measured cyclic resonance frequency, and the instantaneous velocity of the plasma is determined by a formula, that consist of the current time, the cyclic resonance frequency, equivalent inductance of the power supply of railgun, linear inductance and rail length, and as well used as a model of measurement measure capacitance of capacitor, connected in parallel to rail of railgun grounded from one side. Application of plasma velocity measuring method is suitable for the highly-accurate control of plasma acceleration and pushed it to the railgun bodies with controlled acceleration, requiring measurement during movement of the plasma instantaneous values of velocity.
Probabilistic-deterministic approach of controlling the functionality of a technical system in normal and emergency operation modes
Authors: Zababurin Vladimir M. , Egorova Marina A. , Polyakova Yuliya A. 
Published: November 2018

The main disadvantages of the existing methods of managing the current state of technical systems are revealed. A non-standard approach is proposed for managing the functionality of the system in emergency situations.
The character of the dynamics of the recovery processes of the technical system is determined as its state approaches the emergency one on the basis of the recommendations of the theory of self-organized criticality (SOC).
The physical criteria for assessing the current state of the technical system are revealed. The rationale for using the physical indicator of the functional destabilization of the system is given. The signs of the pre-emergency state of the technical system are considered.
A grapho-analytical model for the development of an emergency situation has been developed. The fact of the inevitable increase in the entropy of the system upon its transition to an emergency state is established. Structuring of the system development process in an emergency situation is carried out in three stages.
The methodology for estimating the pre-emergency state of complex open systems is presented. The advantages of the proposed approach to managing the state of technical systems in comparison with traditional ones are established.
Les enjeux d'une nouvelle interface
Authors: Makaremi M. 
Published: November 2018

Les progrès effectués dans les domaines de l'intelligence artificielle et des sciences informatiques auront un impact majeur sur la pratique médicale au cours des décennies à venir. Les investissements considérables déployés par les géants du numérique dans leur filiales santé en sont la preuve.
Les stratégies d'automatisation dont pourraient, quand ils ne le peuvent déjà, bénéficier les praticiens, génèrent peurs et fantasmes. Elles invitent à procéder très rapidement à la réflexion sur les enjeux de l'interface homme-machine (IHM) dans les pratiques médicales et en particulier dans le domaine de l'orthopédie dento- faciale.
Les algorithmes sont certes supérieurs au cerveau humain pour décrypter et analyser des données mais il leur est impossible de créer des codes informatiques pour modéliser le sens clinique. C'est là que réside la plus-value de nos cerveaux - et pour longtemps encore.
The presence of violence at work of health care personnel and their work ability
Authors: Bula Santa , Deklava Liana , Reste Jelena , Lusena-Ezera Inese 
Published: November 2018

Proportion of health care workers of those who believe that the work in progress threatens their health and safety is higher than the average in other sectors. Workers in health care facilities are especially exposed to violence in the workplace [1]. The aim of the study was the evaluation of the presence of violence at work and determination of its effect on the working ability of health care sector workers. The study included the survey of 132 emergency department employees (doctors, physician assistants, nurses) from Kurzeme Region hospitals (Latvia). Questionnaire of violence in the workplace of the health care sector workers and the work ability index assessment questionnaire were used for the data collection. It was found that medical staff of health care establishments experience mostly verbal abuse (97%), less from physical attacks (36%), and intimidation/bullying (30%). The study found that medical personnel are aware of the changes implemented in the workplace (29%), there has been no change (33%), while the impact of changes implemented by medical staff at the workplace has not been experienced (47%). For personnel who have suffered from violence in the workplace, working capacity is generally lower than for the personnel that has not experienced violence in the workplace.
Unterkieferprotrusionsschiene bei obstruktivem
Schlafapnoesyndrom getestet
Authors: Herzog Michael 
Published: November 2018

Marco Pitarch R et al. Effectiveness of a mandibular advancement device in
obstructive sleep apnea patients: a prospective clinical trial. Eur Arch
Otorhinolaryngol 2018; 275: 1903–1911
In einer prospektiven Studie wurde die Effektivität einer
Unterkieferprotrusionsschiene (mandibular advancement device, MAD) bei
Patienten mit obstruktivem Schlafapnoesyndrom getestet. Evaluiert wurden
dabei verschiedene Merkmale der Patienten und der MAD als Prädiktoren des
Behandlungsergebnisses.
Zertifikat „Wundmanagement“ der DDA
Authors: Dissemond J. 
Published: November 2018

ZusammenfassungIn Deutschland leiden aktuell mindestens eine Million Menschen an einer chronischen Wunde unterschiedlichster Genese. Das zentrale Ziel der immer komplexer werdenden Wundtherapie ist es, die physiologischen Prozesse der zuvor gestörten Wundheilung zu unterstützen. Dies kann nur dann gelingen, wenn die Ursachen der Wundheilungsstörungen korrekt diagnostiziert und, wenn möglich, auch therapiert werden. Aus diesem Grund wurde 2008 auf Anregung der DDA ein entsprechendes Curriculum durch eine Expertengruppe der Arbeitsgemeinschaft Wundheilung (AGW) der DDG erstellt. Der Gesamtumfang der Weiterbildung umfasst 16 Stunden, aufgeteilt in zwei Fortbildungseinheiten à 8 Stunden. Der Teil 1 hat den Schwerpunkt „Genese und Diagnostik“, der Teil 2 „Therapie“. Für den Erwerb des Zertikats „Wundmanagement“ der DDA ist es notwendig, Facharzt für Dermatologie und Venerologie zu sein und zusätzlich beide Kurse absolviert zu haben.
Mucinous cystic neoplasm diagnosed by EUS-guided microforceps biopsy
Authors: Orr Jordan , Lockwood Robert , Salaria Safia , Gamboa Anthony , Yachimski Patrick 
Published: November 2018

Abstract
Background and study aims Mucinous cystic neoplasms (MCNs) of the pancreas have malignant potential. Current methods for diagnosing MCNs are inadequate. The aim of this case series is to present a novel method for establishing the diagnosis of MCNs. Clinical information from three patients seen at our institution was collected for a case series presentation. Patients were selected retrospectively based on diagnostic results. Three patients were diagnosed with MCNs based on histopathology obtained via microforceps biopsy. Evolving tissue acquisition techniques, such as microforceps intracystic biopsy, have improved the diagnostic yield of endoscopic ultrasound (EUS).
Successful treatment of paediatric lower limb CRPS by
continuous epidural anaesthesia: a report of 2 cases
Authors: Zyluk Andrzej , Puchalski Piotr 
Published: November 2018

AbstractCRPS occurs in children less frequently than in adults, but in the last two
decades it has become a well-established entity in children and adolescents. The
symptomatology, course, responsiveness to treatment and prognosis of the
paediatric disease is also different from the “adult” form. The paper presents
the successful treatment of two cases of paediatric CRPS involving the lower
limb, by continuous epidural anaesthesia with bupivacaine. Both patients
developed the condition after minor trauma or overuse. CRPS diagnosis was based
on clinical grounds. Both patients presented a history of psychological
distress, due to familial problems. In one patient, the initial treatment was
lumbar sympathetic block, resulting in immediate and complete recovery. After
relapse of the disease at four months, the next intervention included continuous
epidural infusion of bupivacaine, with an excellent and rapid response. In the
2nd case, continuous epidural infusion was used primarily with
the same, excellent and fast result. The article discusses clinical
peculiarities, treatment modalities and other aspects of paediatric CRPS. Poor
awareness of the condition in the paediatric community is also emphasized