bluuebunny/crossref_metadata_2025_split huggingface dataset:
The influence of parenting styles and coping strategies on anxiety symptoms in adolescents: a comparative study of groups with and without non-suicidal self-injury behavior
Authors: Liu Lingjiang , Hu Xinhui , Xie Huabing , Hu Changzhou , Zhou Dongsheng , Zhang Jie , Kong Yangjian , Cheng Fang 
Published: November 2024

Background
During the COVID-19 pandemic, the global incidence of non-suicidal self-injury (NSSI) has been increasing year by year, especially among adolescents, and it is highly correlated with the level of anxiety among teenagers, particularly within Chinese cultural contexts where parenting styles significantly influence adolescent behavior.

Objective
This study examines the role of culturally-influenced parenting styles and adolescent coping strategies in relation to anxiety and NSSI behavior, aiming to clarify these multivariate interactions for better understanding and intervention.

Methods
A cross-sectional survey was conducted with NSSI-diagnosed adolescents from Affiliated Kangning Hospital, Ningbo, China, and healthy adolescents from urban schools. Data on background, parenting styles, coping strategies, and anxiety levels were analyzed using chi-square tests, independent sample t-tests, MANOVA, and regression analysis.

Results
Adolescents with NSSI reported higher anxiety levels, more punishment and interference, and less emotional warmth from their fathers compared to the non-NSSI group (p < 0.001). The NSSI group also relied more on emotion-oriented coping strategies, while the non-NSSI group favored problem-oriented approaches (p < 0.001). Multivariate analyses confirmed significant effects of NSSI behavior, parenting styles, and coping strategies on anxiety levels.

Conclusion
This study found that the anxiety levels of NSSI adolescents were significantly higher than those of non-NSSI adolescents in China, which was closely related to less emotional warmth from parents, more punishment and interference, and emotion-focused coping strategies. The results demonstrate that family environment and coping strategies play a critical role in NSSI behavior and anxiety levels, highlighting the importance of emphasizing emotional support and positive coping strategies in the prevention and intervention of NSSI behavior.
A Prospective Observational Study on the Clinical Profile Assessment of Myocardial Infarction Patients in a Tertiary Care Teaching Hospital
Authors: G.M Ruksaar Faheen , Suni Hanna Merril , C H Thriveni , F Ajmal , S S Arathy , LAL Varun 
Published: November 2024

Background: Cardiovascular Diseases (CVDs) are the single largest contributor to the global burden of disease and are recognized as the leading cause of death globally. CHD has various clinical manifestations ranging from asymptomatic to acute conditions, namely acute coronary syndrome. Cardiovascular risk factors for acute coronary syndrome (ACS) are on the rise in people of Indian origin. Myocardial Infarction (MI) also called as heart attack, infarction means the death of an area of tissue because of interrupted blood supply. Myocardial Infarction has become a growing concern among the cardiovascular diseases, hence the study is conducted in order to assess the clinical profile of patients suffering from MI.
Aim: To assess the clinical presentations, risk factors, short-term complications and management of patients with MI.
Methodology: A prospective observational study was conducted in a tertiary care teaching hospital over six months. A total of 121 patients were selected based on inclusion and exclusion criteria.
Results: Among the 121 patients included, the predominant were males (63.63%). Most of the patients fell under the age group of 51-60 (n=46). The common presenting symptoms were chest pain (42.32%), followed by breathlessness (26.04%) and sweating (15.34%). Most patients had NSTEMI (62.80%) and STEMI (37.19%). Alcohol (23.44%) was major risk factor followed by smoking (22.48%) and diabetes (14.35%). The elevated biomarkers noted were Troponin I (42.14%), Troponin T (37.19%) and CK-MB (6.61%) respectively. The majority of infarctions occurred on inferior wall (30.57%). The most prevalent complication observed was heart failure (14.8%) followed by sinus tachycardia (6.61%), and sinus bradycardia (5.78%). The majority of patients received key medications like anti-platelet agents, statins and anti-coagulants during hospital stay.
Conclusion: The risk of men developing myocardial infarction is more compared to women due to various reasons. It is more likely that the diagnosis of myocardial infarction is neglected due to certain presenting symptoms like epigastric pain, syncope, vomiting, sweating etc., hence this study was conducted with an overview of creating awareness regarding the severity of myocardial infarction along with the advantages of early diagnosis.
Measuring the effectiveness of the sketch procedure for recalling details of a live interactive event
Authors: Eastwood Joseph , Snook Brent , Luther Kirk 
Published: September 2018

SummaryThe effectiveness of a sketch procedure for enhancing the recall of a live interactive event was assessed. Participants (N = 88) engaged in an interaction with a confederate, were administered a sketch, mental reinstatement of context (MRC), or control procedure and then asked to recall the experienced event. Results showed that participants who were administered a sketch procedure recalled more correct details than those administered an MRC or control procedure (d = 0.55 and d = 1.31, respectively). The increased recall was seen primarily for action and object details, with little difference between procedures for recall of person and verbal details. In addition, the effect of interview procedure on the number of incorrect details recalled was nonsignificant. The utility of the sketch procedure for investigative interviewing is discussed.
Regio‐ and Stereoselective Vicinal syn‐Arylation‐Trifluoromethylation of Terminal Arylacetylenes
Authors: Xiao Chang , Wan Hai‐Xing , Zhang Song‐Lin 
Published: September 2018

AbstractOne‐pot three‐component syn‐arylation‐trifluoromethylation of terminal arylalkynes is developed by using an isolated (phen)Cu(III)(CF3)3 complex (phen: phenanthroline) and aryl boronic acids. This reaction is chemoselective that can suppress the competing trifluoromethylation of alkyne C−H and aryl boronic acids. It is also regioselective to install an aryl group on Cα and a CF3 group on Cβ of arylalkynes. Finally, unusual syn‐difunctionalization chemistry is achieved that is complementary to the general anti‐stereochemistry for difunctionalization of alkynes involving trifluoromethylation. The use of a Cu(III)−CF3 complex is crucial to the success that not only acts as a reactive CF3 precursor, but is also responsible for the unusual syn‐stereochemistry. This study allows ready access to vicinal arylated‐trifluoromethylated olefins, which is a widely existing structural motif in many biologically active compounds.
BCR‐ABL1 transcript levels at 4 weeks have prognostic significance for time‐specific responses and for predicting survival in chronic‐phase chronic myeloid leukemia patients treated with various tyrosine kinase inhibitors
Authors: Song Hye‐young , Noh Hayeon , Choi Soo young , Lee Sung‐Eun , Kim Soo‐Hyun , Kee Kyung‐Mi , Yoo Hea‐Lyun , Lee Mi‐young , Kang Ki‐Hoon , Suh Ji‐Hyung , Yang Seon‐young , Jang Eun‐Jung , Lee Jangik I. , Kim Dong‐Wook 
Published: September 2018

AbstractThe present study aimed to assess the clinical impact of BCR‐ABL1 transcript levels determined at an earlier time point than the 3‐month early molecular response (EMR) in chronic‐phase chronic myeloid leukemia (CML‐CP) patients. BCR‐ABL1 transcript levels of CML‐CP patients (n = 258; median age, 43 [range, 18‐81] years) treated with various tyrosine kinase inhibitors (TKIs) were determined at 4 weeks (28 ± 3 days) and at every 3 months of treatment initiation. At 4 weeks, receiver operating characteristic curves revealed that cutoff values of BCR‐ABL1 transcripts for achieving major molecular responses (MMRs) by 12 and 60 months were 40.89% and 39.16%, respectively (95% CI, 0.658‐0.772 and 95% CI, 0.643‐0.758; P < 0.0001). With 40% of BCR‐ABL1 transcripts at 4 weeks (very early MR; VEMR), patients with VEMR achieved higher 3‐month EMR and 4‐week VEMR significantly associated with higher cumulative incidences of 5‐year MMR (89.1% vs 72.3%; P < 0.001) and 5‐year deep molecular response (DMR) (56.5% vs 29.4%; P = 0.001). Furthermore, event‐free survival (EFS)‐a (93.0% vs 84.8%; P = 0.068) and EFS‐b (71.1% vs 57.9%; P = 0.061) by 5 years were also marginally significant. VEMR and 3‐month EMR were achieved in 89 patients, with significantly superior outcomes. In multivariate analyses, lower leukocyte count (P = 0.008) and frontline second‐generation TKI therapy size (P < 0.001) were significantly associated with VEMR achievement, but not baseline BCR‐ABL1 level and CML duration. In conclusion, the 4‐week BCR‐ABL1 transcript levels including VEMR could be important to predict long‐term outcomes and may provide additional information about innate intrinsic sensitivity to CML among individuals.
Mixed‐valence Compounds: AuO2 and AuS
Authors: Tang Meng , Zhang Yanmei , Li Siya , Wu Xi , Jia Yan , Yang Guochun 
Published: September 2018

AbstractMixed‐valence compounds are of great interest due to their interesting properties and wide applications. Recently, gold (Au) chemistry has experienced an unprecedented development. However, Au with mixed‐valence states in Au−O compounds has not been reported thus far. Here, two hitherto unknown AuO2 and AuS compounds with mixed‐valence character were identified with the aid of first‐principles swarm structure searching calculations. AuO2 consists of quasi‐square AuO4 moiety and AuO6 octahedron in which Au shows the mixed‐valence states of III and V, the first example in Au−O binary compounds. AuS contains the linear AuS2 and quasi‐square AuS4 units exhibiting AuI/III mixed‐valence states. The analysis of electronic property demonstrates that AuO2 and AuS are narrow band gap semiconductors with strong hybridization between Au 5d and O 2p or S 3p. With the increase of pressure, Au−O and Au−S compounds show completely different thermodynamic stabilities, resulting from distinct shifting of pressure‐induced atomic orbital energy levels of O and S atoms. Our work provides an opportunity for understanding mixed‐valence character in Au−O and Au−S compounds
Reuniting overnutrition and undernutrition, macronutrients, and micronutrients
Authors: Kim Miji , Basharat Anam , Santosh Ramchandani , Mehdi Syed F. , Razvi Zanali , Yoo Sun K. , Lowell Barbara , Kumar Amrat , Brima Wunnie , Danoff Ann , Dankner Rachel , Bergman Michael , Pavlov Valentin A. , Yang Huan , Roth Jesse 
Published: September 2018

SummaryOver‐nutrition and its late consequences are a dominant theme in medicine today. In addition to the health hazards brought on by over‐nutrition, the medical community has recently accumulated a roster of health benefits with obesity, grouped under “obesity paradox.” Throughout the world and throughout history until the 20thcentury, under‐nutrition was a dominant evolutionary force. Under‐nutrition brings with it a mix of benefits and detriments that are opposite to and continuous with those of over‐nutrition. This continuum yields J‐shaped or U‐shaped curves relating body mass index to mortality. The overweight have an elevated risk of dying in middle age of degenerative diseases while the underweight are at increased risk of premature death from infectious conditions. Micronutrient deficiencies, major concerns of nutritional science in the 20thcentury, are being neglected. This “hidden hunger” is now surprisingly prevalent in all weight groups, even among the overweight. Because micronutrient replacement is safe, inexpensive, and predictably effective, it is now an exceptionally attractive target for therapy across the spectrum of weight and age. Nutrition‐related conditions worthy of special attention from caregivers include excess vitamin A, excess vitamin D, and deficiency of magnesium.
Melatonin potentiates the effects of metformin on glucose metabolism and food intake in high‐fat‐fed rats
Authors: Dantas‐Ferreira Rosana F. , Raingard Helene , Dumont Stephanie , Schuster‐Klein Carole , Guardiola‐Lemaitre Beatrice , Pevet Paul , Challet Etienne 
Published: September 2018

SummaryBackgroundMelatonin is a hormone synthesized mainly by the pineal gland, and secreted only at night. Melatonin has been proposed as a modulator of glucose metabolism.MethodsHere we studied the metabolic effects of melatonin administration alone (s.c. 10 mg/kg) or in combination with metformin (p.o. 300 mg/kg), a widely used anti‐diabetic drug. These treatments were tested on glucose tolerance, insulin sensitivity and food intake in Zucker fatty rats (i.e., bearing a missense mutation in the leptin receptor gene) and high‐fat fed Sprague‐Dawley rats.ResultsMelatonin alone or in combination did not significantly modify glucose tolerance in either model. Melatonin alone in high‐fat fed Sprague‐Dawley improved insulin sensitivity to the level of metformin. In addition, combined treatment further ameliorated insulin sensitivity (+13%), especially during the late phase of rising glycemia. The lack of similar effects in Zucker rats suggests an involvement of leptin signaling in mediating the positive effects of melatonin. Body mass gain in Sprague‐Dawley rats was decreased by both metformin, and combined metformin and melatonin. While melatonin alone did not markedly affect food intake, its combination with metformin led to a more pronounced anorexia (‐17% food intake during the last week), as compared to metformin alone.ConclusionsMelatonin improves the beneficial effects of metformin on insulin sensitivity and body mass gain in high‐fat fed Sprague‐Dawley rats. Therefore, the combination of melatonin and metformin could be beneficial to develop dual therapies to treat or delay type 2 diabetes associated with obesity.
Comparison of microRNAs in the intramuscular adipose tissue from Jinhua and Landrace pigs
Authors: Miao Zhiguo , Wang Shan , Wang Yimin , Wei Panpeng , Khan Muhammad Akram , Zhang Jinzhou , Guo Liping , Liu Dongyang 
Published: September 2018

AbstractMicroRNA (miRNA) is critically involved in lipogenesis occurring in various body parts of humans and animals. In this study, to further investigate the role and distribution of miRNA in porcine intramuscular adipose tissue, small RNAs were extracted from Jinhua and Landrace pigs to identify the expression profiles of miRNAs. miRNA expression profiles revealed that 558 miRNAs including 287 known and 271 novel miRNAs were identified, and 220 of them showed differential expression in the pigs. Gene ontology and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis suggested that the target genes of the differentially expressed miRNAs were involved in fatty metabolism. In conclusion, the current study reveals the active participation of miRNAs in the regulation of adipogenesis in the intramuscular adipose tissue of Jinhua and Landrace pigs.
Apoptosis‐associated speck‐like protein containing a caspase‐1 recruitment domain (ASC) contributes to osteoblast differentiation and osteogenesis
Authors: Sartoretto Suelen , Gemini‐Piperni Sara , da Silva Rodrigo A. , Calasans Monica D. , Rucci Nadia , Pires dos Santos Thais M. , Lima Inayá B. C. , Rossi Alexandre M. , Alves Gutemberg , Granjeiro José M. , Teti Anna , Zambuzzi Willian F. 
Published: September 2018

AbstractThe role of apoptosis‐associated speck‐like protein containing a caspase‐1 recruitment domain (ASC) in bone healing remains to be understood. To address this issue, we investigated the requirement of inflammasome‐related genes in response to bone morphogenetic protein 7 (BMP7)‐induced osteoblast differentiation in vitro. To validate the importance of ASC on osteogenesis, we subjected wild‐type (WT) and ASC knockout C57BL/6 mice (ASC KO) to tibia defect to evaluate the bone healing process (up to 28 days). Our in vitro data showed that there is an involvement of ASC during BMP7‐induced osteoblast differentiation, concomitant to osteogenic biomarker expression. Indeed, primary osteogenic cells from ASC KO presented a lower osteogenic profile than those obtained from WT mice. To validate this hypothesis, we evaluated the bone healing process of tibia defects on both WT and ASC KO mice genotypes and the ASC KO mice were not able to fully heal tibia defects up to 28 days, whereas WT tibia defects presented a higher bone de novo volume at this stage, evidencing ASC as an important molecule during osteogenic phenotype. In addition, we have shown a higher involvement of runt‐related transcription factor 2 in WT sections during bone repair, as well as circulating bone alkaline phosphatase isoform when both were compared with ASC KO mice behavior. Altogether, our results showed for the first time the involvement of inflammasome during osteoblast differentiation and osteogenesis, which opens new avenues to understand the pathways involved in bone healing.
Non‐viral suicide gene therapy in cervical, oral and pharyngeal carcinoma cells with CMV‐ and EEV‐plasmids
Authors: Düzgüneş Nejat , Cheung Jennifer , Konopka Krystyna 
Published: September 2018

AbstractBackgroundCervical cancer is the third most common cause of cancer in women. The 5‐year survival rate in oropharyngeal squamous cell carcinomas is approximately 50% and this rate has not improved in recent decades. These cancers are accessible to direct intervention. We examined the ability of a highly efficient non‐viral vector, TransfeX (ATCC, Manassas, VA, USA), to deliver the suicide gene HSV‐tk to cervical, oral and pharyngeal cancer cells and to induce cytotoxicity following the administration of the prodrug, ganciclovir.MethodsHeLa cervical carcinoma, HSC‐3 and H357 oral squamous cell carcinoma and FaDu pharyngeal carcinoma cells were transfected with cytomegalovirus (CMV)‐ or enhanced episomal vector (EEV)‐driven HSV‐tk plasmids and treated with ganciclovir for 24–120 h. Cell viability was assessed by Alamar blue.ResultsThe viability of HeLa cells was reduced to only 30–40%, despite the very high levels of transgene expression. By contrast, the viability of HSC‐3 cells was reduced to 10%, although transgene expression was 18‐fold lower than that in HeLa cells. An approximately five‐fold higher transgene expression was obtained with the EEV‐plasmid than from the CMV‐plasmid. Nevertheless, HeLa cell viability after suicide gene + ganciclovir treatment was reduced by only 35% compared to 70% with the CMV‐plasmid. For HSC‐3 cells, the reduction was 40% for the EEV‐ and 80% for the CMV‐plasmid. The lower efficiency of transfection with the EEV‐plasmid may explain the lower cytotoxicity.ConclusionsTransfeX‐mediated gene delivery to cervical, pharyngeal and oral cancer cells may be used for suicide gene therapy. The levels of transgene expression, however, do not translate directly to cytotoxicity.
Reproducibility of native T1 mapping for renal tissue characterization at 3T
Authors: Dekkers Ilona A. , Paiman Elisabeth H.M. , de Vries Aiko P.J. , Lamb Hildo J. 
Published: September 2018

BackgroundAdvanced renal disease is characterized by adverse changes in renal structure; however, noninvasive techniques to diagnose and monitor these changes are currently lacking.PurposeTo evaluate the reproducibility of native T1 mapping for renal tissue characterization.Study TypeReproducibility study.PopulationFifteen healthy volunteers (mean age 31 years, range 19–63 years), and 11 patients with diabetic nephropathy (mean age 57 years, range 51–69 years).Field Strength/Sequence3T, modified Look–Locker imaging (MOLLI) 5(3)3.AssessmentIntra‐ and interexamination reproducibility of voxel‐based T1 relaxation times of renal cortex and medulla was assessed in healthy human volunteers and diabetic nephropathy patients.Statistical TestsReproducibility was evaluated using Bland–Altman and intraclass correlation coefficients (ICCs).ResultsIntra‐ and interexamination reproducibility of renal native T1 mapping showed good–strong ICCs (0.83–0.89) for renal cortex and medulla, and moderate–good ICCs (0.62–0.81) for cortex–medulla ratio in both healthy volunteers and diabetic nephropathy patients. Intra‐ and interexamination limits of agreement were respectively (–124 msec, + 82 msec) and (–134 msec, + 98 msec) for renal cortex and (–138 msec, + 107 msec) and (–118 msec, + 151 msec) for medulla. Overall T1 values for renal cortex (P = 0.277) and medulla (P = 0.973) were not significantly different between healthy volunteers and diabetic nephropathy patients, in contrast to the cortex–medulla ratio (P = 0.003).Data ConclusionRenal native T1 mapping is a technique with good–strong intra‐ and examination reproducibility in both healthy volunteers and diabetic nephropathy patients.Level of Evidence: 3Technical Efficacy: Stage 1J. Magn. Reson. Imaging 2019;49:588–596.
How to make continuum solvation incredibly fast in a few simple steps: A practical guide to the domain decomposition paradigm for the conductor‐like screening model
Authors: Stamm Benjamin , Lagardère Louis , Scalmani Giovanni , Gatto Paolo , Cancès Eric , Piquemal Jean‐Philip , Maday Yvon , Mennucci Benedetta , Lipparini Filippo 
Published: September 2018

AbstractWe illustrate the domain decomposition Conductor‐like Screening Model (ddCOSMO) implementation and how to couple it with an existing classical or quantum mechanical (QM) code. We review in detail what input needs to be provided to ddCOSMO and how to assemble it, describe how the ddCOSMO equations are solved and how to process the results to assemble the required quantities, such as Fock matrix contributions for the QM case, or forces for the classical one. Throughout the article, we will make explicit references to the ddCOSMO module, which is an open source, Fortran 90 implementation of ddCOSMO that can be downloaded and distributed under the LGPL license.
Clonotypic Heterogeneity In Cutaneous T-Cell Lymphoma Revealed By Comprehensive Whole Exome/Transcriptome Sequencing
Authors: Iyer Aishwarya , Patterson Jordan , Salopek Thomas , Wong Gane Ka-Shu , Gniadecki Robert 
Published: September 2018

AbstractMycosis fungoides (MF), the most common type of cutaneous T-cell lymphoma, is believed to represent a clonal expansion of a transformed skin resident memory T-cell. T-cell receptor (TCR) clonality (i.e. identical sequences of rearranged TCRα, β and γ), the key premise of this hypothesis, has been difficult to document conclusively because malignant cells are not readily distinguishable from the tumor infiltrating, reactive lymphocytes, which contribute to the TCR clonotypic repertoire of MF. Here we have successfully adopted the technique of targeted whole exome and whole transcriptome sequencing (WES/WTS) to identify the repertoire of rearranged TCR genes in tumor enriched samples from patients with MF. Although most of the investigated biopsies of MF had the expected monoclonal rearrangements of TCRγ of the frequency corresponding to the frequency of tumor cells, in half of the samples we detected multiple (up to seven) TCRα and -β clonotypes by WES and WTS. Our findings are compatible with the model in which the initial malignant transformation in MF does not occur in mature, memory T-cells but rather at the level of T-lymphocyte progenitor after TCRγ rearrangement but before TCRβ or TCRα rearrangements. The WES/WTS method is potentially applicable to other types of T-cell lymphomas and enables comprehensive characterization of the TCR repertoire and mutational landscape in these malignancies.