bluuebunny/crossref_metadata_2025_split huggingface dataset:
Phenotypic and molecular dissection of metaplastic breast cancer and the prognostic implications
Authors: McCart Reed Amy Ellen , Kalaw Emarene , Nones Katia , Bettington Mark , Lim Malcolm , Bennett James , Johnstone Kate , Kutasovic Jamie Rose , Saunus Jodi Marie , Kazakoff Stephen , Xu Qinying , Wood Scott , Holmes Oliver , Leonard Conrad , Reid Lynne Estelle , Black Debra , Niland Colleen , Ferguson Kaltin , Gresshoff Irma , Raghavendra Ashwini , Harvey Kate , Cooper Caroline , Liu Cheng , Kalinowski Lauren , Reid Andrew Scott , Davidson Morgan , Pearson John V , Pathmanathan Nirmala , Tse Gary , Papadimos David , Pathmanathan Rajadurai , Harris Gavin , Yamaguchi Rin , Tan Puay Hoon , Fox Stephen B , O'Toole Sandra A , Simpson Peter Thomas , Waddell Nicola , Lakhani Sunil R 
Published: October 2018

AbstractMetaplastic breast carcinoma (MBC) is relatively rare but accounts for a significant proportion of global breast cancer mortality. This group is extremely heterogeneous and by definition exhibits metaplastic change to squamous and/or mesenchymal elements, including spindle, squamous, chondroid, osseous, and rhabdomyoid features. Clinically, patients are more likely to present with large primary tumours (higher stage), distant metastases, and overall, have shorter 5‐year survival compared to invasive carcinomas of no special type. The current World Health Organisation (WHO) diagnostic classification for this cancer type is based purely on morphology – the biological basis and clinical relevance of its seven sub‐categories are currently unclear. By establishing the Asia‐Pacific MBC (AP‐MBC) Consortium, we amassed a large series of MBCs (n = 347) and analysed the mutation profile of a subset, expression of 14 breast cancer biomarkers, and clinicopathological correlates, contextualising our findings within the WHO guidelines. The most significant indicators of poor prognosis were large tumour size (T3; p = 0.004), loss of cytokeratin expression (lack of staining with pan‐cytokeratin AE1/3 antibody; p = 0.007), EGFR overexpression (p = 0.01), and for ‘mixed’ MBC, the presence of more than three distinct morphological entities (p = 0.007). Conversely, fewer morphological components and EGFR negativity were favourable indicators. Exome sequencing of 30 cases confirmed enrichment of TP53 and PTEN mutations, and intriguingly, concurrent mutations of TP53, PTEN, and PIK3CA. Mutations in neurofibromatosis‐1 (NF1) were also overrepresented [16.7% MBCs compared to ∼5% of breast cancers overall; enrichment p = 0.028; mutation significance p = 0.006 (OncodriveFM)], consistent with published case reports implicating germline NF1 mutations in MBC risk. Taken together, we propose a practically minor but clinically significant modification to the guidelines: all WHO_1 mixed‐type tumours should have the number of morphologies present recorded, as a mechanism for refining prognosis, and that EGFR and pan‐cytokeratin expression are important prognostic markers. Copyright © 2018 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
Influence of synthesis conditions on the production of molecularly imprinted polymers for the selective recovery of isovaleric acid from anaerobic effluents
Authors: Tonucci Marina C , Fidélis Ana Luíza S , Baeta Bruno Eduardo L , Tarley César Ricardo T , de Aquino Sérgio F 
Published: October 2018

AbstractTwo molecularly imprinted polymers (MIPs) – poly(methacrylic acid‐co‐TRIM) (TRIM, trimethylolpropanetrimethacrylate) and poly(acylamide‐co‐TRIM) – were synthesized in different solvents for the selective recovery of isovaleric acid (template) generated during the anaerobic digestion process. The chemical and structural characterizations of the synthetic adsorbent were carried out by Fourier transform infrared spectroscopy, TGA and porosimetry through N2 adsorption–desorption isotherms. The selective and adsorptive performances of the imprinted polymers were evaluated by kinetic, isothermal, thermodynamic and selectivity studies and by adsorbent reuse experiments. The poly(methacrylic acid‐co‐TRIM) synthesized with dimethyl sulfoxide:chloroform presented higher selectivity and adsorption capacity for isovaleric acid in the presence of six volatile fatty acids. The kinetic results were well adjusted to the pseudo‐nth order and intraparticle diffusion models, leading to k values of 10−4 and 6 × 10−5 for the best synthesis of MIPs and not‐imprinted polymers, respectively. Moreover, the Sips model best described the adsorption isotherm and generated a maximum adsorption capacity of ca 209 mg g−1 (at 25 °C). Cycles of MIP use–desorption–reuse indicated that the selective adsorbent performed better than commercial adsorbents, losing less than 3% of adsorption capacity after three cycles. © 2018 Society of Chemical Industry
Land and access: A framework for analysing mining, migration and development in Melanesia
Authors: Bainton Nicholas A. , Banks Glenn 
Published: October 2018

AbstractIn this paper we propose that we can best make sense of mining‐induced in‐migration in Melanesia through the dual frame of “land” and “access”, which can both be seen as a type of “capital” or “asset” in the way that Anthony Bebbington used these terms in his well‐known “capitals and capabilities” framework for analysing rural livelihoods. The concept of land provides a useful point of entry for understanding the relationship between mining, migration and development in this setting. We argue that if land is central to the making of social relations in Melanesia (that land is a social relation), then mining changes the meaning and values that can flow from land, and these changes induce manoeuvres on the part of residents and in‐migrants as they attempt to control or become part of the social relations that constitute land in order to access the development benefits derived from mining activities. In the end, these actions remake place, and irrevocably reshape relationships and senses of place that precede mining.
The industrial ethic, corporate refusal and the demise of the social function in mining
Authors: Kemp Deanna , Owen John R. 
Published: October 2018

AbstractThe social function in mining is in a state of decline. Recent changes among the world's major mining companies suggest that corporations are responding to the dual pressure of profit maximization and sustainable development by cutting back on the social function of their business. Our approach draws on two conceptual platforms to describe and analyse the development and the subsequent demise of the “social function” in the global mining industry. This approach captures the various exchanges that occur within and across place defining boundaries of “company” and “community”, and importantly, as a means for explaining the significance of changes to the industry's organizational configurations. We argue that mining companies are places of refusal and resistance. A redirection of organizational flows of capital, information and other resources is required for mining companies to meet the increasing demand for social performance capability, and avoid creating costly legacies for the future.
AFTERWORD Places, migration and sustainability: anthropological reflections on mining and movement
Authors: Macintyre Martha 
Published: October 2018

AbstractBased on ethnographic research around the Misima and Lihir gold mines in Papua New Guinea, this Afterword provides anthropological reflections on the main themes of the articles in this issue. Endorsing the call for interdisciplinary research on mining, I present instantiations of the varying meanings of place, migration and sustainability. I describe variations in perceptions of place between different sites and these are also subject to change over time. The commoditization of land and engagement with capitalism profoundly alter knowledge and understanding of place and ideals of development. Migration occurs at different rates over the life of the mine but has a lasting effect on the stability of the community and its economic sustainability. Mining companies often resort to simplistic and inadequate solutions to the environmental and social problems created by their projects.
What's the value of being different when everyone is? The effects of distinctiveness on performance in homogeneous versus heterogeneous categories
Authors: Haans Richard F. J. 
Published: October 2018

Research SummaryIs moderate distinctiveness optimal for performance? Answers to this question have been mixed, with both inverted U and U‐shaped relationships being argued for and found in the literature. I show how nearly identical mechanisms driving the distinctiveness‐performance relationship can yield both U‐shaped and inverted U‐shaped effects due to differences in relative strength, rather than their countervailing nature. Incorporating distinctiveness heterogeneity, I theorize a U‐shaped effect in homogeneous categories that flattens into an inverted U in heterogeneous categories. Results combining a topic model of 69,188 organizational websites with survey data from 2,279 participants in the Dutch creative industries show a U‐shaped effect in homogeneous categories, flattening and then disappearing in more heterogeneous categories. How distinctiveness affects performance thus depends entirely on how distinct others are.Managerial SummaryA core strategy recommendation is to be different from competitors. Recent work highlights the notion of optimal distinctiveness—being different enough to escape competition yet similar enough to be legitimate, thus yielding the highest performance. This article challenges the notion that one “optimal” level of distinctiveness exists and focuses on distinctiveness heterogeneity (representing variation in firm positions in a category) as a key contextual factor. Results from a sample of firms in the Dutch creative industries show that either being entirely different or entirely the same to competitors pays off when one's category is very homogeneous. However, being different loses its performance effects entirely when heterogeneity in firm positions is higher. Being different from competitors, therefore, no longer pays when others tend to be different, too.
Application of data mining methods for effort estimation of software projects
Authors: Karna Hrvoje , Vicković Linda , Gotovac Sven 
Published: October 2018

SummaryInformation technology companies currently use data mining techniques in different areas with the goal of increasing the quality of decision‐making and to improve their business performance. The study described in this paper uses a data mining approach to produce an effort estimation of a software development process. It is based on data collected in a Croatian information technology company. The study examined 27 software projects with a total effort exceeding 42 000 work hours. The presented model employs a modified Cross‐Industry Standard Process for Data Mining, where prior to model creation, additional clustering of projects is performed. The results generated by the proposed approach generally had a smaller effort estimation error than the results of human experts. The applied approach has proved that sound results can be gained through the use of data mining within the studied area. As a result, it would be wise to use such estimates as additional input in the decision‐making process.
Cyclic behavior of unit bucket for tripod foundation system supporting offshore wind turbine via model tests
Authors: Jeong Yeong‐Hoon , Kim Jae‐Hyun , Park Heon‐Joon , Kim Dong‐Soo 
Published: October 2018

AbstractOffshore wind energy has been growing up as a promising renewable energy source. Recently, tripod suction bucket foundation is rapidly expanding as a foundation system supporting the offshore wind turbine. In offshore environment, wind turbine foundation structures should be designed considering cyclic loading which can lead to permanent deformation of structure, tilting problem, and overall degradation of soil stiffness. However, it is technically difficult to predict the cyclic behavior of the tripod accurately because the cyclic behaviors of the tripod bucket can be inferred from vertical pullout and compression behaviors of each single bucket elements. In this paper, a series of model tests was performed by applying cyclic vertical compression and extension loadings to a single bucket element that is one element of the tripod foundation. Loading directions, level, and rate were controlled for investigating of cyclic behavior of tripod foundation. On the basis of testing results, the permanent deformation and cyclic stiffness response of tripod suction caisson were discussed. Based on the test results, it was confirmed that the cyclic behavior of the single bucket is affected by the load level and rate. In addition, the behavior showed quite different trends with the loading directions: compression, pullout, and two‐way.
INTERRELATION BETWEEN WEAK FRAGMENTS OF DOUBLE NEGATION SHIFT AND RELATED PRINCIPLES
Authors: FUJIWARA MAKOTO , KOHLENBACH ULRICH 
Published: October 2018

AbstractWe investigate two weak fragments of the double negation shift schema, which are motivated, respectively, from Spector’s consistency proof of ACA0 and from the negative translation of RCA0, as well as double negated variants of logical principles. Their interrelations over both intuitionistic arithmetic and analysis are completely solved.
THE SOLIDITY AND NONSOLIDITY OF INITIAL SEGMENTS OF THE CORE MODEL
Authors: FUCHS GUNTER , SCHINDLER RALF 
Published: October 2018

AbstractIt is shown that $K|{\omega _1}$ need not be solid in the sense previously introduced by the authors: it is consistent that there is no inner model with a Woodin cardinal yet there is an inner model W and a Cohen real x over W such that $K|{\omega _1}\,\, \in \,\,W[x] \setminus W$. However, if ${0^{\rm{\P}}}$ does not exist and $\kappa \ge {\omega _2}$ is a cardinal, then $K|\kappa$ is solid. We draw the conclusion that solidity is not forcing absolute in general, and that under the assumption of $\neg {0^{\rm{\P}}}$, the core model is contained in the solid core, previously introduced by the authors.It is also shown, assuming ${0^{\rm{\P}}}$ does not exist, that if there is a forcing that preserves ${\omega _1}$, forces that every real has a sharp, and increases $\delta _2^1$, then ${\omega _1}$ is measurable in K.
SEX DIFFERENCES IN THE SOCIAL ECOLOGY OF BREASTFEEDING: A MIXED METHODS ANALYSIS OF THE BREASTFEEDING VIEWS OF EXPECTANT MOTHERS AND FATHERS IN THE US EXPOSED TO ADVERSITY
Authors: Dayton Carolyn J. , Johnson Angela , Hicks Laurel M. , Goletz Jessica , Brown Suzanne , Primuse Trazell , Green Kiddada , Nordin Myung Ae , Welch Robert , Muzik Maria 
Published: October 2018

AbstractDespite the significant health benefits of breastfeeding for the mother and the infant, economic class and race disparities in breastfeeding rates persist. Support for breastfeeding from the father of the infant is associated with higher rates of breastfeeding initiation. However, little is known about the factors that may promote or deter father support of breastfeeding, especially in fathers exposed to contextual adversity such as poverty and violence. Using a mixed methods approach, the primary aims of the current work were to (1) elicit, using qualitative methodology, the worries, barriers and promotive factors for breastfeeding that expectant mothers and fathers identify as they prepare to parent a new infant, and (2) to examine factors that influence the parental breastfeeding intentions of both mothers and fathers using quantitative methodology. A sample (N=95) of expectant, third trimester mothers and fathers living in a low-income, urban environment in Midwestern USA, were interviewed from October 2013 to February 2015 about their infant feeding intentions. Compared with fathers, mothers more often identified the benefits of breastfeeding for the infant’s health and the economic advantage of breastfeeding. Mothers also identified more personal and community breastfeeding support resources. Fathers viewed their own support of breastfeeding as important but expressed a lack of knowledge about the breastfeeding process and often excluded themselves from discussions about infant feeding. The results point to important targets for interventions that aim to increase breastfeeding initiation rates in vulnerable populations in the US by increasing father support for breastfeeding.
Dynamics of policy change in authoritarian countries: a multiple-case study on China
Authors: Wu Yipin 
Published: October 2018

AbstractUsing evidence from China, this study proposes the conflict expansion model to explore how pressure for policy change can build up to overcome resisting force and stimulate a response from decisionmakers in an authoritarian context. Tracing the policy change processes of four national policies, this study finds that the social pressure mobilised by media reports focused on specific events is a major force for facilitating policy change in China. However, owing to institutional constraints, the influences of societal actors are sporadic, incident-based and varied by population. The policy change process is protracted and difficult when it encounters resistance from state actors who have multiple institutional access channels for influencing the decision-making process. The power distribution between the facilitating and resisting forces determines whether policy change proceeds quickly or arduously.
TO PROFIT MAXIMIZE, OR NOT TO PROFIT MAXIMIZE: FOR FIRMS, THIS IS A VALID QUESTION
Authors: Robson Gregory 
Published: October 2018

Abstract:According to an influential argument in business ethics and economics, firms are normatively required to maximize their contributions to social welfare, and the way to do this is to maximize their profits. Against Michael Jensen's version of the argument, I argue that even if firms are required to maximize their social welfare contributions, they are not necessarily required to maximize their profits. I also consider and reply to Waheed Hussain's ‘personal sphere’ critique of Jensen. My distinct challenge to Jensen seems to me fatal to any view according to which firms are normatively required to maximize their profits.
The structure of triple homomorphisms onto prime algebras
Authors: LIU CHENG–KAI 
Published: October 2018

AbstractTriple homomorphisms on C*-algebras and JB*-triples have been studied in the literature. From the viewpoint of associative algebras, we characterise the structure of triple homomorphisms from an arbitrary ⋆-algebra onto a prime *-algebra. As an application, we prove that every triple homomorphism from a Banach ⋆-algebra onto a prime semisimple idempotent Banach *-algebra is continuous. The analogous results for prime C*-algebras and standard operator *-algebras on Hilbert spaces are also described.
Preliminary dosimetric evaluation of 90Y-BPAMD as a potential agent for bone marrow ablative therapy
Authors: Rabiei Ali , Yousefnia Hassan , Zolghadri Samaneh , Shamsaei Mojtaba 
Published: October 2018

AbstractAimBone-seeking radiopharmaceuticals are potential therapeutic tools for bone marrow ablation in patients with multiple myeloma. In this procedure, estimation of radiation absorbed dose received by the target and non-target organs is one of the most important parameters that should be undertaken. This research revolves around the absorbed dose to human organs after 90Y-BPAMD injection.Materials and methods90Y-(4-{[(bis(phosphonomethyl))carbamoyl]methyl}-7,10-bis(carboxymethyl)-1,4,7,10-tetraazacyclododec-1-yl) acetic acid (90Y-BPAMD) complex was successfully prepared under optimised conditions. The human absorbed dose of the complex was estimated based on the biodistribution data on rats using the radiation-absorbed dose-assessment resource method. The target to non-target absorbed dose ratios for the complex was compared with the ratios for 166Ho-DOTMP, as the main radiopharmaceutical for bone marrow ablation.ResultsAs expected, the highest amounts of absorbed dose were observed in the bone surface and the bone marrow with 2·52 and 2·29 mGy/MBq, respectively. The red marrow to the most organ absorbed dose ratios for 90Y-BPAMD are much higher than the ratios for 166Ho-DOTMP.Findings90Y-BPAMD has interesting characteristics compared with 166Ho-DOTMP and can be considered as a high potential agent for bone marrow ablative therapy of the patient with multiple myeloma.
A Study of Consecutive Terrestrial Gamma‐ray Flashes Using the Gamma‐ray Burst Monitor
Authors: Stanbro M. , Briggs M. S. , Roberts O. J. , Cramer E. S. , Cummer S. A. , Grove J. E. 
Published: October 2018

AbstractThe Fermi Gamma‐ray Burst Monitor (GBM) has detected terrestrial gamma‐ray flash (TGF) pulses and TGF pairs with separations from submilliseconds to several minutes. Enhancements in the TGF rate are reobserved on successive orbits. We report on the distribution of TGF pulse separations observed with Fermi GBM. Additionally, a detailed analysis is performed on TGFs that have temporal associations within 3.5 ms with radio atmospheric signals (sferics) from the World Wide Lightning Location Network or the Earth Networks Total Lightning Network. Sferics are typically associated with lightning discharges, but the relativistic runaway electron avalanche process, according to models, should also produce radio emissions. The separations times between TGFs show a gap from 10 ms to 1 s that we interpret as showing differing origins for the separations below 10 ms and those above 1 s. Analysis of paired TGFs with separation time ≥1 s reveals 51 pairs with a sferic association with both members. The majority of these pairs have members originating from separate cells in thunderstorm systems, but 10 pairs have geolocations consistent with originating from the same cell. The minimum separation time of pairs from the same cell is 10 s, with an average separation time of 56 s. This leads to implications on TGF generation models and the recharge time of the large‐scale electric field at the source of the production of the TGF. This separation time would result in a constraint on the recharge time of the large‐scale electric field before an additional TGF can be produced.
Characterizing Complex Surface Ruptures in the 2013 Mw 7.7 Balochistan Earthquake Using Three‐Dimensional Displacements
Authors: Zhou Yu , Parsons Barry E. , Walker Richard Thomas 
Published: October 2018

AbstractWe use satellite‐derived high‐resolution topography and orthoimages, namely, preearthquake Advanced Land Observing Satellite World 3‐D data and postearthquake Pleiades data, to retrieve 3‐D displacements in the 2013 Balochistan, Pakistan, earthquake. Previous studies of this earthquake have revealed many complex rupture patterns, such as off‐fault deformation (near‐field strike‐slip displacements smaller than the far field) and inelastic surface deformation (horizontal shortening on the surface significantly larger than that from simple elastic model). In this paper, we reanalyze the complexities of surface ruptures in a systematic way using the newly derived 3‐D displacements. In doing so, we made use of the vertical component of the curl and the horizontal divergence of the displacement field. By comparing the off‐fault deformation and curl field along the rupture, we found that curl is a good measure of the width of the deformation zone. The curl width ratio (CWR)—the ratio of the basic resolution of the curl field and curl width—was used to quantify the degree of surface slip localization. When CWR ≥ 0.9, there is no or very little off‐fault deformation, whereas when CWR ≤ 0.6, surface deformation is almost 100% distributed. The distributed deformation observed is controlled by both the fault geometry and local material types. Despite the overall strike slip with some thrusting, the divergence shows localized extension or enhanced shortening in the near field due to fault geometric variations at a spatial scale of tens to hundreds of meters, consistent with the 3‐D displacements and geological interpretations.