bluuebunny/crossref_metadata_2025_split huggingface dataset:
An Australian local diagnostic reference level for paediatric whole-body 18F-FDG PET/CT
Authors: Alkhybari Essam Mohammed , McEntee Mark F. , Willowson Kathy P. , Brennan Patrick C. , Kitsos Theo , Kench Peter L. 
Published: January 2019

Objective:
The aim of this study is to report a local diagnostic reference level (DRL) for paediatric whole-body (WB) fludeoxyglucose (18F-FDG) positron emission tomography (PET) CT examinations.

Methods:
The Australian Radiation Protection and Nuclear Safety Agency (ARPANSA) national DRL (NDRL) age category (0–4 years and 5–14 years), the International Commission on Radiological Protection age category (ICRP age) (&lt;1, &gt;1–5, &gt;5–10, and &gt;10–15 years), and European guideline weight category ( EG weight) (&lt;5, 5–&lt;15, 15–&lt;30, 30–&lt;50, and 50–&lt;80 kg) were used to determine a local DRL for WB 18F FDG PET/CT studies. Two-structured questionnaires were designed to collect dose data, patient demographics, equipment details, and acquisition protocols for WB 18F-FDG PET/CT procedures. The local DRL was based on the median 18F-FDG administered activity (MBq), dose–length product (DLP), and the CT dose index volume (CTDIvol), values. The effective dose (E) was also calculated and reported.

Results:
The local DRLs for 18F-FDG administered activity, CTDIvol and DLP values based on ARPANSA age and ICRP age were increased from lower to higher age categories. For the EG weight category, the local DRL for 18F-FDG administered activity, CTDIvol and DLP values were increased from the low EG weight category to the high EG weight category. The mean administered activity in our study based on ICRP age category &gt;1–5, &gt;5–10, and &gt;10–15 years is 79.97, 119.40, and 176.04 MBq, which is lower than the mean administered activity reported in the North American Consensus guideline published in 2010 (99, 166, and 286 MBq) and European Association of Nuclear Medicine and Dosage Card (version 1.5.2008) (120, 189, and 302 MBq). However, the mean administered activity in our study based on ICRP age category &lt;1 year was 55 MBq compared to the EANM Dosage card (version 1.5.2008) (70 MBq) and the NACG 2010 (51 MBq). Our study shows that the finding for ICRP age category &lt;1 year was similar to the NACG 2010 value.

Conclusion:
The determined local DRL values for the radiation doses associated with WB 18F FDG PET/CT examinations are differed considerably between the ARPANSA and ICRP age category and EG weight category. Although, the determined 18F-FDG value for ICRP &lt; 1 year is in good agreement with available publish data, it is preferable to optimise the 18F-FDG administered activity while preserving the diagnostic image quality.

Advances in knowledge:
The local DRL value determined from WB 18F-FDG PET/CT examinations may help to establish the ARPANSA NDRL for WB FDG 18F-PET/CT examinations.
Accuracy of sonographic fetal weight estimation in full-term singleton pregnant women
Authors: Tas Emre Erdem , Kir Edip Alptug , Yilmaz Gamze , Yavuz Ayse Filiz 
Published: January 2019

Objectives: To investigate the factors which might influence the sonographic fetal weight estimation (SFWE) accuracy.
Methods: This prospective study was conducted among 949 singleton term pregnant women who delivered at a tertiary center, from January 2017 to December 2017. All participants’ maternal (i.e. parity, age, body mass index and gestational weight gain during pregnancy), fetal sonographic (i.e. fetal presentation, amniotic fluid index, localization of placenta and estimated fetal weight) and neonatal (birth weight and gender) characteristics were recorded. A p<0.05 was considered significant.
Results: The mean absolute percent error (APE) values of SFWE was 8.2±6.5 percent, and overall failure ratio (APE >10%) was 33%. In failure group, primiparous woman and cephalic presentation fetus were significantly more common compared to accuracy group (55.9% vs.44.8%; p=0.001 and 98% vs. 95.2%; p=0.03, respectively). In contrast, the mean neonatal birth weight (NBW) value was significantly lower in failure group compared to success group (3250±565 gr vs. 3404±410 gr; p=0.001). The correlation between SFWE and NBW was linear, however negative, and significant (p=0.001). Logistic regression analysis revealed that primiparous woman, cephalic presentation fetus and <3300 gr NBW were independent risk factors for the SFWE failure (relative risks were 1.6, 2.8 and 2.4 respectively, p<0.05).
Conclusion: SFWE has a high correlation with NBW, however it’s accuracy is still unsatisfactory, and depend on many unpredictable and inconsistent factors.
How to cite this:Tas EE, Kir EA, Yilmaz G, Yavuz AF. Accuracy of sonographic fetal weight estimation in full-term singleton pregnant women. Pak J Med Sci. 2019;35(1):34-38. doi: https://doi.org/10.12669/pjms.35.1.373
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
The role of inflammatory markers following Ramadan Fasting
Authors: Mushtaq Rubina , Akram Ambreen , Mushtaq Rehana , Khwaja Sobia , Ahmed Shabbir 
Published: January 2019

Objectives: The aim of present study was to investigate the effect of fasting during Ramadan on plasma adiponectin and TNF-α levels.
Methods: This is a cross sectional study, conducted at Federal Urdu University of Arts, Science & Technology (FUUAST), Karachi, comprising a total of 55 (50%) females and 55 (50%) males whose ages ranged between 20 and 40 years, and fasted during Ramadan (June-July 2014) were enrolled in the study. Subjects were separated into normal weight, overweight and obese males and females. Anthropometric measurements and Fasting venous blood samples were taken at first and last (29th) day of Ramadan. Plasma adiponectin and TNF-alpha levels were assayed with ELISA kits. All values were calculated and presented as mean ± standard error of the mean (SEM) and by using analysis of variance (ANOVA) for repeated measures. P values < 0.05 were accepted as significant.
Results: Body mass index (BMI) (Kg/m2) in over-weight and obese male subjects exhibited considerable reduction (P<0.05; P<0.05), post Ramadan when compared to their respective pre Ramadan fasting weights. Noticeable and significant reduction was also observed in BMI of obese females (P<0.05). Post Ramadan Overweight Males (P<0.05) and Post Ramadan Obese Males (P<0.001) exhibited significantly elevated plasma adiponectin (μg/mL) values. While plasma adiponectin mean concentration of only obese females were significantly improved at last week of Ramadan (P<0.01). Fasting in Ramadan significantly decreased TNF-α (pg/mL) levels of post obese males and females than Pre-Ramadan-groups (P<0.05; P<0.01) respectively.
Conclusion: The study reports of noticeable changes with Ramadan fasting resulting increase of plasma adiponectin and decrease of TNF-α levels as well as body weight. The study strongly suggests further investigations on larger sample sizes with possible association of dietary restrictions and weight loss on mechanism of enhanced adiponectin and reduced TNF-α in obese and overweight persons who fast on Ramadan pattern.
How to cite this:Mushtaq R, Akram A, Mushtaq R, Khwaja S, Ahmed S. The role of inflammatory markers following Ramadan Fasting. Pak J Med Sci. 2019;35(1):77-81. doi: https://doi.org/10.12669/pjms.35.1.95
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Novel strategies for clinical investigation and biomarker discovery: a guide to applied metabolomics
Authors: Carneiro Gabriel , Radcenco Andres Lopez , Evaristo Joseph , Monnerat Gustavo 
Published: January 2019

Abstract
Metabolomics is an emerging technology that is increasing both in basic science and in human applications, providing a physiological snapshot. It has been highlighted as one of the most wide ranging and reliable tools for the investigation of physiological status, the discovery of new biomarkers and the analysis of metabolic pathways. Metabolomics uses innovative mass spectrometry (MS) allied to chromatography or nuclear magnetic resonance (NMR). The recent advances in bioinformatics, databases and statistics, have provided a unique perception of metabolites interaction and the dynamics of metabolic pathways at a system level. In this context, several studies have applied metabolomics in physiology- and disease-related works. The application of metabolomics includes, physiological and metabolic evaluation/monitoring, individual response to different exercise, nutritional interventions, pathological processes, responses to pharmacological interventions, biomarker discovery and monitoring for distinct aspects, such as: physiological capacity, fatigue/recovery and aging among other applications. For metabolomic analyses, despite huge improvements in the field, several complex methodological steps must be taken into consideration. In this regard, the present article aims to summarize the novel aspects of metabolomics and provide a guide for metabolomics for professionals related to physiologist and medical applications.
Imagination as a key factor in LMLS in transnational families
Authors: Wei Li , Hua Zhu 
Published: January 2019

Abstract
This article argues that imagination plays a key role in whether and how members of transnational families individually and collectively maintain or relinquish their heritage languages and adopt other languages as part of their multilingual repertoires. Imagination is defined here as the vision of where and what one might be or become at some future point in time. We base our argument on linguistic ethnography over two decades with transnational families of Chinese ethnic origin in the UK. Families that seem to have kept their heritage languages and families that have given them up were invited to talk about where, what and how they would see themselves in ten years’ time, and a selection of them are subsequently interviewed and observed after the ten-year period. Their responses are analysed in terms of their constructed experiences, environments and visions of the future; their perceptions and imaginations of different places and cultures; key moments in re-evaluation, or re-imagining, that led to major behavioural changes; and self-evaluation of their imaginations. Particular attention is given to the dynamics of differences and tensions between the imaginations of individuals of the same families, as well as changes to the imaginations over time. Theoretical and methodological implications of studying imagination as a key factor for language maintenance and language shift, and for bilingualism research generally, are discussed.
“Prétendre comme si on connaît pas une autre langue que le swahili”: Multilingual parents in Norway on change and continuity in their family language policies
Authors: Purkarthofer Judith , Steien Guri Bordal 
Published: January 2019

AbstractIn this article, we examine how parents explain their choices of transmitting certain languages to their children, a key element of family language policies (FLP), in light of their dynamic linguistic repertoires and biographic experiences. Contributing to the framework of FLP, we focus in particular on parents’ memories, their narratives of multilingual upbringing in the past, and how these are used to construct present FLP. We analyze conversations where six multilingual parents in Norway talk about their experiences and intentions regarding FLP, and in particular, their reasons for the transmission of (some of their) languages to their children. The parents of three of the families are from the Democratic Republic of Congo (DRC), and in three others at least one of the parents migrated from Germany. We find that the parents align their decisions with both prior and new experiences. They relate to their language(s), their past and their current family life, and express the wish for continuity across the lifespan. At the same time, they demonstrate a certain flexibility and willingness to adapt to the constantly changing environments that they and their children experience and in which they navigate. Through their complex accounts, their memories and lived language experiences, we can understand parents’ manifold positions as regards their children’s linguistic repertoires.
A Comprehensive Review on Fiber Bragg Grating and Photodetector in Optical Communication Networks
Authors: Kumar Suresh , Rathee Shiwani , Arora Payal , Sharma Deepak 
Published: January 2019

Abstract
The optical fiber communication offers a huge bandwidth for data transmission at higher data rates but to increase the throughput for long-haul networks, metro data links, and data centers, additional fiber is required which is not economical. For effective reception of signals at the receiver, the photo detector in optical communication requires higher efficiency, lower noise, ultrafast response and optimum received signal strength. The inherent dispersion and nonlinear impairments in optical fiber communication system can be overcome by using the Fiber Bragg Grating (FBG) which is a Dispersion Compensating Module. FBG helps to improve the long-haul transmission by providing an efficient system performance. This paper presents a detailed review of FBG and photo detectors and their use in an Optical communication system. This paper will help the researchers to find useful material at a single platform.
Hydrogenation reaction pathways in chemistry of white phosphorus
Authors: Gafurov Zufar N. , Kagilev Alexey A. , Kantyukov Artyom O. , Sinyashin Oleg G. , Yakhvarov Dmitry G. 
Published: January 2019

Abstract
Approaches for preparation of P–H bond containing derivatives directly from white phosphorus are summarized in this microreview. Transfer hydrogenation of P4 involving the activation and reaction of white phosphorus in the coordination sphere of transition metal complexes is a convenient and powerful route to the hydrogenated compounds. Electrochemical methods have also become popular in modern synthetic chemistry; these provide easy access to highly reactive intermediates, which can be selectively generated in situ and used for subsequent synthetic processes. These electrochemical routes provide efficient and environmentally safe methods for preparation of phosphorus derivatives bearing P–H bond. The mechanisms of the proposed processes and the nature of the intermediates formed in the overall electrochemical process are disclosed. The methods elaborated operate under the principals of “green chemistry” and can be considered as efficient alternatives to some classical pathways.
Gamma radiation shielding properties of glasses within the TeO2-TiO2-ZnO system
Authors: Almatari M. 
Published: January 2019

Abstract
Radiations are widely used in hospitals and health services in radiotherapy and molecular imaging using x-ray and gamma radiation which considered as the most penetrating radiations and very difficult to shield. In this study, the radiation shielding properties of different zinc oxide (ZnO) concentrations of the (95-x)TeO2-5TiO2-xZnO (x=5, 10, 15, 20, 25, 30 and 40 mol%) glass system was investigated to be introduced as a new transparency effective shielding material. In order to study shielding properties, mass attenuation coefficients in the energy range of 0.015–15 MeV photon energies for the current glass system were calculated using ParShield software. Moreover, half value layer, mean free path and effective atomic number were evaluated using the obtained attenuation coefficient. The results indicated that if ZnO was added to the current glass system the mass attenuation coefficient will be decreased as well as effective atomic number values. The highest mass attenuation coefficient at all energies was found to be in TT5Z5 glass sample as well as the effective atomic number value.
MLML2R: an R package for maximum likelihood estimation of DNA methylation and hydroxymethylation proportions
Authors: Kiihl Samara F. , Martinez-Garrido Maria Jose , Domingo-Relloso Arce , Bermudez Jose , Tellez-Plaza Maria 
Published: January 2019

Abstract
Accurately measuring epigenetic marks such as 5-methylcytosine (5-mC) and 5-hydroxymethylcytosine (5-hmC) at the single-nucleotide level, requires combining data from DNA processing methods including traditional (BS), oxidative (oxBS) or Tet-Assisted (TAB) bisulfite conversion. We introduce the R package MLML2R, which provides maximum likelihood estimates (MLE) of 5-mC and 5-hmC proportions. While all other available R packages provide 5-mC and 5-hmC MLEs only for the oxBS+BS combination, MLML2R also provides MLE for TAB combinations. For combinations of any two of the methods, we derived the pool-adjacent-violators algorithm (PAVA) exact constrained MLE in analytical form. For the three methods combination, we implemented both the iterative method by Qu et al. [Qu, J., M. Zhou, Q. Song, E. E. Hong and A. D. Smith (2013): “Mlml: consistent simultaneous estimates of dna methylation and hydroxymethylation,” Bioinformatics, 29, 2645–2646.], and also a novel non iterative approximation using Lagrange multipliers. The newly proposed non iterative solutions greatly decrease computational time, common bottlenecks when processing high-throughput data. The MLML2R package is flexible as it takes as input both, preprocessed intensities from Infinium Methylation arrays and counts from Next Generation Sequencing technologies. The MLML2R package is freely available at https://CRAN.R-project.org/package=MLML2R.
Wittgenstein on Thinking as a Process or an Activity
Authors: Lin Francis Y. 
Published: January 2019

Abstract
In this paper I focus on a major aspect of the later Wittgenstein’s investigation of thinking – his discussion of the idea of thinking as a process or an activity. I shall show that Wittgenstein’s remarks, apart from some concerning the methodology and conception of philosophy, are grammatical remarks, meaning that they describe the use of the word “thinking” and can be agreed to by every competent speaker. I thus show that Wittgenstein’s investigation of thinking is a grammatical one, and hence that there is no inconsistency between his conception of philosophy and his philosophical practice. In the process of doing so, I shall also review previous studies on this topic and point out their deficiencies.
Möchte Chomsky erklären, was Wittgenstein beschreibt?
Authors: Uth Melanie 
Published: January 2019

Abstract
This article examines the relation between the philosophy of language proposed by the later Wittgenstein in his Philosophical Investigations, and his ambition to cure philosophy from the mapping of linguistic expressions to extra-linguistic entities, on the one hand, and Chomsky's statements regarding language, meaning, and thought, and regarding the sense and non-sense of different fields of linguistic research, on the other. After a brief descriptive comparison of both approaches, it is argued that Chomsky's criticism on Wittgenstein's theory of meaning (Chomsky 1974 – 1996), or on Wittgenstein's basic concepts such as e. g. rule-following (Chomsky 2000 onwards), respectively, is (a) unwarranted and (b) caused by a fundamental misconception. Moreover, it is argued that the hypothesis evoked by Grewendorf (1985: 126), according to which „Chomsky would like to explain what Wittgenstein describes“, is misleading since the objects of investigation of Chomsky and Wittgenstein are in complementary distribution one to the other.
Farbe und Raum
Authors: Ertz Timo-Peter 
Published: January 2019

Abstract
In his Remarks on Colour Wittgenstein repeatedly mentions that white glass is necessarily non-transparent. However, Wittgenstein does not provide convincing evidence for this thesis. He touches on several disanalogies between white and coloured glass, but the coherence of these disanalogies is occasionally somewhat overestimated.
Wittgenstein's remarks on transparent white glass appear incomplete and I am not aware of any philosophical works that closes the gaps in his remarks on transparent white. This paper will try to close at least one of these gaps and show to what extent there is a conceptual link between white and non-transparency.
Nonparametric Testing for Unknown Age (UBAL) Class of Life Distribution
Authors: Abu-Youssef S. E. , Ali Nahed S. A. , Bakr M. E. 
Published: January 2019

Abstract
In this article, a test statistic for testing exponentiality versus a used better than aged in Laplace transform ordering class of life distribution based on a U-statistic is proposed. Pitman’s asymptotic efficiencies of the test are calculated and compared to other tests. The percentiles of this test statistic are tabulated for censored and non-censored data, and the powers of this test are estimated for some famously alternative distributions in reliability, such as the Weibull, Makeham, linear failure rate, and Gamma distributions. Finally, examples in different areas are used as practical applications of the proposed test.
Optogenetic Stimulation of the Superior Colliculus Confers Retinal Neuroprotection in a Mouse Glaucoma Model
Authors: Geeraerts Emiel , Claes Marie , Dekeyster Eline , Salinas-Navarro Manuel , De Groef Lies , Van den Haute Chris , Scheyltjens Isabelle , Baekelandt Veerle , Arckens Lutgarde , Moons Lieve 
Published: January 2019

Glaucoma is characterized by a progressive loss of retinal ganglion cells (RGCs) in the eye, which ultimately results in visual impairment or even blindness. Because current therapies often fail to halt disease progression, there is an unmet need for novel neuroprotective therapies to support RGC survival. Various research lines suggest that visual target centers in the brain support RGC functioning and survival. Here, we explored whether increasing neuronal activity in one of these projection areas could improve survival of RGCs in a mouse glaucoma model. Prolonged activation of an important murine RGC target area, the superior colliculus (SC), was established via a novel optogenetic stimulation paradigm. By leveraging the unique channel kinetics of the stabilized step function opsin (SSFO), protracted stimulation of the SC was achieved with only a brief light pulse. SSFO-mediated collicular stimulation was confirmed by immunohistochemistry for the immediate-early gene c-Fos and behavioral tracking, which both demonstrated consistent neuronal activity upon repeated stimulation. Finally, the neuroprotective potential of optogenetic collicular stimulation was investigated in mice of either sex subjected to a glaucoma model and a 63% reduction in RGC loss was found. This work describes a new paradigm for optogenetic collicular stimulation and a first demonstration that increasing target neuron activity can increase survival of the projecting neurons.SIGNIFICANCE STATEMENTDespite glaucoma being a leading cause of blindness and visual impairment worldwide, no curative therapies exist. This study describes a novel paradigm to reduce retinal ganglion cell (RGC) degeneration underlying glaucoma. Building on previous observations that RGC survival is supported by the target neurons to which they project and using an innovative optogenetic approach, we increased neuronal activity in the mouse superior colliculus, a main projection target of rodent RGCs. This proved to be efficient in reducing RGC loss in a glaucoma model. Our findings establish a new optogenetic paradigm for target stimulation and encourage further exploration of the molecular signaling pathways mediating retrograde neuroprotective communication.