bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sulodexide Monotherapy in Chronic Idiopathic Subjective Tinnitus: A Randomized Controlled Trial
Authors: El Beaino Marc , McCaskey Meghan K. , Eter Elie 
Published: May 2018

ObjectiveTo report the therapeutic value of sulodexide monotherapy in the management of patients with chronic subjective idiopathic tinnitus.Study DesignRandomized double‐blinded controlled trial.SettingSingle tertiary care institution.Subjects and MethodsObservations from 124 patients who received either sulodexide or placebo were collected from the patients’ medical records. Computer‐generated tables were used to allocate treatments. Patients took 1 tablet of the drug or placebo each morning and evening for 40 consecutive days. The response was assessed by the Tinnitus Handicap Inventory and the Mini‐Tinnitus Questionnaire.ResultsBetween 2014 and 2017, 124 patients were divided into 2 treatment arms. The sulodexide group encompassed 63 patients, whereas the placebo arm contained 61 patients. Tinnitus Handicap Inventory and Mini‐Tinnitus Questionnaire scores were more decreased in the sulodexide arm compared to the placebo group (P =. 03 and P <. 01, respectively).ConclusionsSulodexide monotherapy decreases chronic subjective idiopathic tinnitus.
Short-term outcomes of endoscopic submucosal dissection for superficial cecal tumors: a comparison between extension and nonextension into the appendiceal orifice
Authors: Boda Kazuki , Oka Shiro , Tanaka Shinji , Tanaka Hidenori , Matsumoto Kenta , Yamashita Ken , Sumimoto Kyoku , Hirano Daiki , Tamaru Yuzuru , Ninomiya Yuki , Hayashi Nana , Chayama Kazuaki 
Published: May 2018

Background: Few studies have investigated the use of endoscopic submucosal dissection (ESD) for cecal tumors extending into the appendiceal orifice. Herein, we assessed the feasibility and safety of ESD for cecal tumors extending into the appendiceal orifice. Methods: We retrospectively examined the outcomes of ESD for 78 patients with 78 cecal tumors (male/female ratio, 40/38; mean [standard deviation, SD] age, 67 [9] years; mean [SD] tumor size, 32 [15] mm), who underwent ESD at the Hiroshima University Hospital between October 2008 and March 2016. The indication for ESD in cecal tumors extending into the appendiceal orifice was recognition of the distal edge of the lesion in the appendix. They were classified into two groups: patients with cecal tumors extending (Group A: 29 patients, 29 tumors) and not extending (Group B: 49 patients, 49 tumors) into the appendiceal orifice. We compared the outcomes of ESD between both groups. Results: No significant differences in clinicopathological characteristics were observed between both groups. The rate of severe submucosal fibrosis in Group A (48%) was significantly higher than that in Group B (24%) ( p < 0.05). The mean (SD) procedure speed in Group A (14 [10] mm2/min) was significantly slower than that in Group B (23 [16] mm2/min) ( p < 0.01). The en bloc resection rates in Groups A and B were 90% and 96%, respectively. There were no significant differences in adverse events reported between both groups. Conclusions: ESD for cecal tumors with extension into the appendiceal orifice is effective and safe.
Complement C5 but not C3 is expendable for tissue factor activation by cofactor-independent antiphospholipid antibodies
Authors: Müller-Calleja Nadine , Ritter Svenja , Hollerbach Anne , Falter Tanja , Lackner Karl J. , Ruf Wolfram 
Published: May 2018

Key PointsCofactor-independent aPLs cause PDI- and complement-dependent monocyte TF activation. C3, but not C5, is required for TF activation and aPL-induced thrombosis.
Doctors, suicide and mental illness
Authors: Gerada Clare 
Published: May 2018

This article focuses on doctors and suicide. It provides real examples to illustrate why doctors die by their own hand. These reasons are replicated in the general population, but also include a host of additional risk factors related to being a doctor. In each case, information about the doctor is in the public domain or, as in one case, consent from the next of kin has been obtained for a detail not in the public domain. The author is a doctors' doctor, heading up a confidential health service for doctors with mental illness or addiction, the National Health Service Practitioner Health Programme. Mortality data from the programme (January 2008–January 2017) will also be included. For the sake of confidentiality, data is collated and details regarding age and gender have been approximated.Declaration of interestNone.
Venetoclax for Patients With Chronic Lymphocytic Leukemia With 17p Deletion: Results From the Full Population of a Phase II Pivotal Trial
Authors: Stilgenbauer Stephan , Eichhorst Barbara , Schetelig Johannes , Hillmen Peter , Seymour John F. , Coutre Steven , Jurczak Wojciech , Mulligan Stephen P. , Schuh Anna , Assouline Sarit , Wendtner Clemens-Martin , Roberts Andrew W. , Davids Matthew S. , Bloehdorn Johannes , Munir Talha , Böttcher Sebastian , Zhou Lang , Salem Ahmed Hamed , Desai Monali , Chyla Brenda , Arzt Jennifer , Kim Su Young , Verdugo Maria , Gordon Gary , Hallek Michael , Wierda William G. 
Published: May 2018

Purpose Venetoclax is an orally bioavailable B-cell lymphoma 2 inhibitor. US Food and Drug Administration and European Medicines Agency approval for patients with 17p deleted relapsed/refractory chronic lymphocytic leukemia [del(17p) CLL] was based on results from 107 patients. An additional 51 patients were enrolled in a safety expansion cohort. Extended analysis of all enrolled patients, including the effect of minimal residual disease (MRD) negativity on outcome, is now reported. Patients and Methods Overall, 158 patients with relapsed/refractory or previously untreated (n = 5) del(17p) CLL received venetoclax 400 mg per day after an initial dose ramp up. Responses were based on 2008 International Workshop on Chronic Lymphocytic Leukemia criteria, with monthly physical exams and blood counts. Computed tomography scan was mandatory at week 36, after which assessment made was by clinical evaluation. Marrow biopsy was performed when complete remission was suspected. MRD was assessed by flow cytometry. Results Patients had a median of two prior therapies (range, zero to 10 therapies), 71% had TP53 mutation, and 48% had nodes that were ≥ 5 cm. Median time on venetoclax was 23.1 months (range, 0 to 44.2 months) and median time on study was 26.6 months (range, 0 to 44.2 months). For all patients, investigator-assessed objective response rate was 77% (122 of 158 patients; 20% complete remission) and estimated progression-free survival at 24 months was 54% (95% CI, 45% to 62%). For 16 patients who received prior kinase inhibitors, objective response rate was 63% (10 of 16 patients) and 24-month progression-free survival estimate was 50% (95% CI, 25% to 71%). By intent-to-treat analysis, 48 (30%) of 158 patients achieved MRD below the cutoff of 10−4 in blood. Common grade 3 and 4 adverse events were hematologic and managed with supportive care and/or dose adjustments. Conclusion Venetoclax achieves durable responses and was well tolerated in patients with del(17p) CLL. A high rate of blood MRD < 10−4 was achieved in this high-risk population.
SMART Cancer Navigator: A Framework for Implementing ASCO Workshop Recommendations to Enable Precision Cancer Medicine
Authors: Warner Jeremy L. , Prasad Ishaan , Bennett Makiah , Arniella Monica , Beeghly-Fadiel Alicia , Mandl Kenneth D. , Alterovitz Gil 
Published: May 2018

Purpose Data standards and interoperability are critical for improving care for patients with cancer. Recent efforts by ASCO include the Data Standards and Interoperability Summit in 2016, which led to the Omics and Precision Oncology and Advancing Interoperability workshops. To facilitate improved patient care, several recommendations for data sharing and standardization were made to the community. Methods To address these recommendations, we developed SMART Cancer Navigator, a Web application that uses application programming interfaces to gather clinical and genomic data from 11 public knowledge bases ranging from basic to clinical content coverage; three (CIViC, ClinVar, and OncoKB) explicitly linked genomic variants to clinical factors such as prognosis and treatment selection. We illustrated the utility of this application by selecting one of the monthly case studies presented by the ASCO University Molecular Oncology Tumor Board: Ovarian Cancer (BRCA Mutation). We also performed analyses on information from the three clinico-genomic knowledge bases to corroborate previous work and illustrate the state of data sharing among publicly available resources. Results SMART Cancer Navigator aggregates and contextualizes data from 11 different knowledge bases and stores user queries in a lightweight Web application that can link into Fast Healthcare Interoperability Resources–enabled electronic health records. Potentially relevant clinical trials and/or approved treatments were identified for three mutations found in a hypothetical patient with advanced ovarian cancer. A comparison of the three clinico-genomic knowledge bases indicated substantial differences in coverage at the gene and variant levels. Conclusion SMART Cancer Navigator has immediate relevance to practicing oncologists and others. Additional knowledge bases can be added without undue effort. As a first step toward utility, we generalized and disseminated the resulting implementation ( https://smart-cancer-navigator.github.io ) and data sets.
Embryonic bone morphogenetic protein and nodal induce invasion in melanocytes and melanoma cells
Authors: Sinnberg Tobias , Niessner Heike , Levesque Mitch P. , Dettweiler Christoph , Garbe Claus , Busch Christian 
Published: May 2018

Despite recent progress in melanoma therapy via inhibition of activated oncogenes or immune stimulation, most stage IV melanoma patients still have limited survival times. Both therapeutic approaches eventually fail to prevent further invasion and metastasis, which is driven by a morphological process termed epithelial-mesenchymal transition (EMT). We previously demonstrated that inhibition of EMT in melanoma cells via antagonizing the bone morphogenetic protein (BMP)-pathway abrogated EMT and neural crest migration of melanoma cells in the chick embryo.Here, we show that BMP-2 is highly expressed in invasive melanoma cells and is elevated in the serum of stage IV melanoma patients compared to stage IB-IIC patients and healthy controls. Highly BMP-2-expressing melanoma cells display enhanced invasion in the rhombencephalon of the chick embryo. In addition to driving neural crest migration in the zebrafish embryo, the agonists BMP-2, BMP-7 and nodal induce EMT/invasion in radial growth phase melanoma cells and in human melanocytes in skin reconstructs. Blocking either BMP or nodal-signaling by antagonists (noggin, lefty) or the Alk4/5/7-receptor inhibitor SB431542 decreases EMT and invasion of melanoma cells in human epidermal skin reconstructs. Together, our data suggest that inhibition of EMT-inducing pathways in melanoma might be a therapeutic approach to attenuate melanoma cell invasiveness.
Hospitalizations due to alcohol intoxication among children and adolescents – data from one clinical hospital in Poland
Authors: Kamińska Halla , Gawlik Aneta , Gawlik Tomasz , Małecka-Tendera Ewa 
Published: May 2018

Cel pracyCelem pracy było określenie częstości hospitalizacji z powodu zatruć alkoholem etylowym
w Oddziale Pediatrii oraz próba identyfikacji czynników mających wpływ na ich występowanie w populacji dzieci i młodzieży.MetodaAnalizie poddano dokumentację medyczną 227 pacjentów hospitalizowanych z powodu zatruć etanolem. Sto osiem (48%) pacjentów stanowiły dziewczęta, 119 (52%) chłopcy. Średni wiek badanych wynosił 14,9 lat ±2,1 SD. Przeanalizowano dane dotyczące samych pacjentów, ich rodzin oraz okoliczności zdarzenia.WynikiZatrucia etanolem stanowiły 2,8% ogółu hospitalizacji, a liczba hospitalizacji w latach 2000-2011 miała tendencję wzrostową, z wahaniami w poszczególnych latach. Dominującymi napojami alkoholowymi były alkohole wysokoprocentowe. Ponad 10% pacjentów wymagało krótkotrwałej hospitalizacji w warunkach Oddziału Anestezjologii i Intensywnej Terapii.

U 13% u dzieci stwierdzano dodatkowe zatrucie lekami lub narkotykami, a u 10% zatruciu towarzyszył uraz kończyn lub głowy. U 25% dziewcząt odnotowano ryzykowne zachowania seksualne. Większość dzieci pochodziła z rodzin pełnych z wykształceniem podstawowym, a w ponad 20% z nich obecny był alkoholizm. W rodzinach niepełnych, częściej nieobecnym rodzicem był ojciec, a brak stałego źródła dochodu częściej dotyczył matek.WnioskiNie istnieją jednolite standardy wielospecjalistycznej opieki medycznej nad dziećmi zatrutymi etanolem. Wskazana jest identyfikacja dzieci spożywających alkohol przez Lekarzy Podstawowej Opieki Zdrowotnej, Lekarzy Pediatrów, Pedagogów i Psychologów, a także zapewnienie długofalowej i kompleksowej opieki nad nieletnimi, których hospitalizowano
z powodu zatrucia etanolem.
The effects of psychological help on assertive behaviors in family members of schizophrenia patients
Authors: Skotnik Aleksandra , Samochowiec Agnieszka 
Published: May 2018

Cel pracyCelem pracy było określenie związku pomiędzy korzystaniem (lub nie) z pomocy psychologicznej, przez członków rodziny osób chorych na schizofrenię, a przejawianymi przez nich zachowaniami asertywnymi w stosunku do bliskich chorych.MetodaDo grupy badanej zakwalifikowano 34 osoby, które prowadziły gospodarstwo domowe ze swoimi bliskimi, chorymi na schizofrenię. W badaniu wykorzystano Kwestionariusz Kompetencji Społecznych (KKS) autorstwa Matczak oraz Kwestionariusz Radzenia Sobie w Sytuacjach Stresowych (CISS) w polskiej adaptacji Wrześniewskiego i wsp. Dane socjodemograficzne zebrano przy pomocy ankiety własnego autorstwa.WynikiWystąpił związek pomiędzy ogólną tendencją do unikania działania w sytuacji problemowej a skłonnością do poszukiwania kontaktów społecznych w celu poradzenia sobie ze stresem. Jak również zachowania asertywne korelują z tendencją do angażowania się w czynności zastępcze w sytuacji problemowej. Większa gotowość do asertywnego zachowania cechuje osoby, które w sytuacji stresowej ujawniały skłonność do unikania myślenia o problemie i działania na rzecz jego aktywnego rozwiązania. Analizy pokazały również, iż częściej zachowania asertywne przejawiały osoby młodsze, które też radziły sobie ze stresem ujawniając styl unikowy.WnioskiNie potwierdził się związek pomiędzy korzystaniem przez bliskich osób chorych na schizofrenię z pomocy psychologicznej a ujawnianiem zachowań asertywnych w stosunku do chorego. Istotnym natomiast był wniosek, iż większą skłonnością do zachowań asertywnych wykazywały się osoby młodsze, które radziły sobie ze stresem w sposób unikowy.
The Jagiellonian Idea as Expression of the Political Culture
Authors: Banaś Monika 
Published: May 2018

The Jagiellonian Idea as Expression of the Political Culture: Core Constitutive Values and Their Possible Contemporary Implementations
The article aims to discuss the concept of political culture as a powerful tool for shaping thoughts and actions of individuals and communities (societies). By elaborating on the Jagiellonian Idea (JI) – its specific features and implementation, the author seeks to provide answers to several questions including: what made the JI a vibrant political and social concept being undertaken over centuries by some politicians, social leaders, researchers and scholars – is it just an attractive narrative which recalls times when Poland was a powerful state or is it a realistic program still applicable to contemporary societies? What kind of features of the JI concept may be selected, adjusted and developed today in the international and intercivizational dimensions? If at all possible, thus by what kind of means and under what conditions? These and other aspects of the JI as a specific expression of political culture are the core of the article.
The Republic of Poland at the Crossroads of Two Cultures
Authors: Kowalska-Stus Hanna 
Published: May 2018

The Republic of Poland at the Crossroads of Two Cultures
The boundary of the Latin and Orthodox Church in the Piast times was a political border. These two boundaries fostered intensification of cultural differences. Christianity shaped the image of man, state, history, esthetic views as well as religious, social and political customs within two distinct cultures: Latin and Hellenic. On the Orthodox side, the patronage of faith in these areas was more unequivocal. In the times of the First Polish Republic both cultures met in one state. The political factor dominated in Latin American countries. It dictated the methods of action also to the Church. The conflict that was begun by the reign of Władysław Jagiełło and deepened by Sigismund III. Due to the Union of Brest, it triggered the conflict between Poland, Polish and Lithuanian Ruthenia and as a consequence – Moscow. The adaptation that Ruthenia had undergone in the Republic of Poland had far-reaching political, social, economic and cultural consequences. As a result of Moscow’s subsequent consolidation of Ruthenian lands, these processes affected all of these areas in the Moscow State. The conversion that occurred in the Republic of Poland on Ruthenian lands created a foundation for forming Ukrainian identity created by Austria. This fact is perceived in Russia as separatism used in geopolitical interests of many countries, including Poland, against Russia. Jagiellonian Poland that came to existence in the period of confessional tensions in Europe was subjected to internal contradictory cultural trends and political conflicts in the region, whereas Rome made efforts to control Christianity. These circumstances did not create prospects for development of the Republic of Poland.
The Federal Idea in Poland in the Interwar Period: Idealism or Pragmatism?
Authors: Łysek Wojciech 
Published: May 2018

The Federal Idea in Poland in the Interwar Period: Idealism or Pragmatism?
The final months of World War I were marked by the concept of national self-determination. At that time Józef Piłsudski and his followers were putting into practice the so-called federal idea, which aimed at the maintaining of Polish influence in the territories of the pre-partition Poland. However, attempts to put this concept into practice faced national aspirations of Lithuanians and Ukrainians. These two nations intended to build their own states. Despite spectacular victory of the Polish army over the Red Army at Warsaw, the federal idea failed. The final end to the project came in 1921. The article presents a wider historical and political context for the foreign policy visions of Piłsudski and his aspiration to create a federal structure within the Polish borders.
The Last Jagiellonian: John Paul II and the Jagiellonian Idea
Authors: Kowal Paweł 
Published: May 2018

The Last Jagiellonian: John Paul II and the Jagiellonian Idea
The Jagiellonian idea was a constant inspiration in the political and social action of John Paul II in relation to Poland and Central Europe throughout the entire period of his pontificate. It is difficult to find another political idea – apart from his consistently anti-totalitarian and anti-communist stance – which would determine his teaching to a greater extent. The purpose of this article is to present the author’s interpretation as to which experiences and ideas shaped this approach of the Polish pope. Reference will be made to the pope’s statements, his political thought and practical actions as the head of the Holy See.
Connecting reminiscence, art making and cultural heritage: A pilot art-for-dementia care programme
Authors: Tan Michael Koon Boon 
Published: May 2018

Abstract
The incidence of dementia in Singapore is increasing and strategies to care for people with dementia are necessary. Let’s Have Tea at the Museum is a pilot participatory visual art programme designed for clients at an Alzheimer’s Disease Association (ADA) Singapore day care centre. The programme, which combines reminiscence with art-making, aims at enabling participants to further explore the heritage collection at the Peranakan Museum to reawaken memories and promote personal expression. This study involved eight participants (seven females and one male) all aged 70 years and older, with early-stage or moderate-stage Alzheimer’s disease. Video recordings and journal entries were collected to study the effects of the programme on the participants. Data were analysed and interpreted using a grounded theory approach to identify general themes and facilitate focused analyses. The three themes identified in this study that support the benefits of the programme include the following: (1) fostering space for self-discovery, growth and socializing; (2) art as a resource for multi-sensorial engagement and stimulation; and (3) encouraging play and boosting morale. Further use and development of the programme is recommended as a strategy to care for and enrich the lives of people with Alzheimer’s disease.
Social capital and participation: The role of community arts festivals for generating well-being
Authors: Brownett Tristi 
Published: May 2018

Abstract
Community arts festivals have a potential role in fostering social capital and population well-being. This small, exploratory study collected and analysed qualitative data from eight semi-structured interviews with festival organizers. Thematic analysis was applied to the interview transcripts. The findings suggest that festivals create bridging social capital. Festivals also stimulate self-efficacy, which facilitates participation, an emotional response and may lead to a sense of personal well-being, with a living legacy for the community. The article posits a model to articulate the suggested interrelationship between these concepts. Very little research exists on the contribution of arts festivals towards community health and well-being. This nascent research therefore adds to the body of knowledge, and suggests the importance of developing participatory activity at local arts and cultural festivals for community health and well-being.
Atomistic simulations of ultra-short pulse laser ablation of aluminum: validity of the Lambert-Beer law
Authors: Eisfeld Eugen , Roth Johannes 
Published: May 2018

Abstract
Based on hybrid molecular dynamics/two-temperature simulations, we study the validity of the application of Lambert-Beer’s law, which is conveniently used in various modeling approaches of ultra-short pulse laser ablation of metals. The method is compared to a more rigorous treatment, which involves solving the Helmholtz wave equation for different pulse durations ranging from 100 fs to 5 ps and a wavelength of 800 nm. Our simulations show a growing agreement with increasing pulse durations, and we provide appropriate optical parameters for all investigated pulse durations.