bluuebunny/crossref_metadata_2025_split huggingface dataset:
Follicle-Stimulating Hormone Is an Autocrine Regulator of the Ovarian Cancer Metastatic Niche Through Notch Signaling
Authors: Gera Sakshi , Kumar S. Sandeep , Swamy Shalini N , Bhagat Rahul , Vadaparty Annapurna , Gawari Ramesh , Bhat Ramray , Dighe Rajan R 
Published: December 2018

AbstractThe association between the upregulated Notch and FSH signaling and ovarian cancer is well documented. However, their signaling has been investigated independently and only in the primary tumor tissues. The aim of this study was to investigate the interactive effects of FSH and Notch signaling on ovarian cancer proliferation, formation, and maintenance of disseminated ovarian cancer cells. The roles of Notch and FSH in ovarian cancer pathogenesis were investigated with ovarian cancer cell lines and specific antibodies against Notch and FSH receptor (FSHR). FSH upregulated Notch signaling and proliferation in ovarian cancer cells. High levels of FSH were detected in the ascites of patients with serous ovarian adenocarcinoma. Spheroids from the patients’ ascites, as well as the spheroids from ovarian cancer cell lines under low attachment culture conditions, expressed FSHβ subunit mRNA and secreted the hormone into the medium. In contrast, primary ovarian tumor tissues and cell line monolayers expressed very low levels of FSHβ. Ovarian cancer cell spheroids also exhibited higher expression of FSH receptor and Notch downstream genes than their monolayer counterparts. A combination of FSHR and Notch antagonistic antibodies significantly inhibited spheroid formation and cell proliferation in vitro. This study demonstrates that spheroids in ascites express and secrete FSH, which regulates cancer cell proliferation and spheroidogenesis through Notch signaling, suggesting that FSH is an autocrine regulator of cancer metastasis. Furthermore, Notch and FSHR are potential immunotherapeutic targets for ovarian cancer treatment.
Development of Asymmetric Reactions Catalyzed by Ruthenium Complexes with Two Kinds of Ligands
Authors: Ohkuma Takeshi , Kurono Nobuhito , Arai Noriyoshi 
Published: December 2018

Abstract
Two types of chiral Ru(II) complexes, each with two kinds of ligands, have been designed and utilized as catalysts for several asymmetric reactions under appropriate conditions. The first type, the diphosphine/diamine–Ru(II)-type complexes, were found to catalyze the hydrogenation of a variety of simple and functionalized ketones as well as imino compounds with high activity and enantioselectivity. The double asymmetric hydrogenation of α,β-unsaturated ketones into the chiral saturated alcohols was achieved by using the dual catalyst system, which reversibly forms two catalytic species. The asymmetric isomerization of primary allylic alcohols into the optically active aldehydes with almost perfect enantioselectivity was realized with this type of catalyst. The second type, the amino acid/diphosphine–Ru(II)-type complexes combined with Li compounds, exhibited excellent catalyst performance in the asymmetric cyanosilylation of aldehydes as well as simple and functionalized ketones. The isolated Ru·Li bimetallic complexes were suitable for the asymmetric hydrocyanation of aldehydes. This combined system was applicable to the asymmetric conjugate hydrocyanation of α,β-unsaturated ketones and carboxylic acid derivatives, and the Strecker-type reaction of the π-isoelectronic N-alkoxycarbonyl aldimines. This account describes the concept underlying the design of these catalysts, and the catalyst performance in the asymmetric reactions.
Unified Total Synthesis of Madangamine Alkaloids
Authors: Suto Takahiro , Yanagita Yuta , Nagashima Yoshiyuki , Takikawa Shinsaku , Kurosu Yasuhiro , Matsuo Naoya , Miura Kazuki , Simizu Siro , Sato Takaaki , Chida Noritaka 
Published: December 2018

AbstractThe full details of a unified total synthesis of madangamine alkaloids are disclosed. Our central strategy is based on the construction of a common ABCE-tetracyclic system, followed by the late-stage installation of various D-rings. The common intermediate is assembled through N-acyliminium cyclization of a propargylsilane, and formation of the (Z,Z)-skipped diene. Stereoselective synthesis of the (Z,Z)-skipped diene is especially challenging, and is accomplished by the combination of Z-selective hydroboration of the 1,1-disubstituted allene and subsequent Migita-Kosugi-Stille coupling. Macrocyclic alkylation enables the late-stage variation of the D-rings on the common tetracyclic intermediate, resulting in the collective total syntheses of madangamines A–E. The synthetic madangamine alkaloids exhibited inhibitory activities against a variety of human cancer cell lines.
PENSANDO ÀS MARGENS DA BASE: CURRÍCULO E SABERES LOCAIS NA BASE NACIONAL COMUM CURRICULAR
Authors: Oliveira Marcia Lisbôa Costa de , Eletério Lúcia Helena Abreu 
Published: December 2018

O trabalho desenvolve uma análise crítica do processo de elaboração da Base Nacional Comum Curricular (BNCC) brasileira, homologada em dezembro de 2017, focalizando alguns conceitos que ela incorpora e apresenta os resultados preliminares de um estudo de caso único cujo objetivo é investigar as concepções e conhecimentos sobre a BNCC construídos por um grupo de professoras do município de São Gonçalo (Rio de Janeiro – Brasil). A BNCC é um documento de caráter normativo que “define o conjunto orgânico e progressivo das aprendizagens essenciais” que todos os alunos da educação básica devem construir durante a sua escolarização “e indica os conhecimentos e competências que se espera que todos os estudantes desenvolvam” (BRASIL, 2017, p.7). Os resultados preliminares da pesquisa indicam que os docentes do município em que desenvolvemos o estudo de caso não se apropriaram inteiramente dos conhecimentos que lhes permitiriam uma participação mais qualitativa na elaboração da parte diversificada do currículo local. Entendemos que a participação das comunidades escolares nessa construção poderia funcionar como uma forma de resistência à padronização oriunda da influência das perspectivas neoliberais na educação brasileira, pela assunção de saberes que ficaram à margem da Base. No entanto, tendo em vista o modo como o processo está sendo desenvolvido, constatamos o risco de reforço das desigualdades educacionais derivado do silenciamento dos saberes locais pela não-participação das comunidades escolares municipais na construção do currículo.
O peso do sofrimento pedagógico em episódios e histórias de vida
Authors: Colombo Gomes Gysele Da Silva 
Published: December 2018

O objetivo principal do presente estudo foi discutir a forma como participantes de um curso de pós-graduação lato sensu, três professoras brasileiras de língua inglesa em formação continuada, constroem discursivamente o sofrimento do professor. Buscou-se também enfocar a coerência apresentada pelas professoras participantes para a associação do vocábulo sofrimento a seu significado etimológico. Norteada pelos parâmetros da Sociolinguística Interacional (RIBEIRO&GARCEZ, 2002), o referencial teórico adotado na pesquisa tem como base os estudos das narrativas orais (LABOV, 1972; [1967] 2003; BASTOS, 2005; 2008; 2015) e as histórias de vida (LINDE, 1993). Trata-se de uma pesquisa de paradigma qualitativo e interpretativista (DENZIN; LINCOLN, 2006; ERICKSON, 1986; MINAYO, 2002; ANDRÉ, 2008), cujos dados foram gerados com o uso de entrevistas como atividades reflexivas com potencial exploratório (ARPE) em conformidade às propostas da Prática Exploratória (ALLWRIGH, 1991; 2003c; 2006; MILLER, 2012; 2010; MORAES BEZERRA, 2007). O sofrimento é caracterizado como a dificuldade em ser professordevido à discriminação e ao menosprezo social; e como o resultado da ratificação do senso comum, do produto de políticas sociais e educacionais, em construções de idealização profissional social não verbalizadas. Os resultados alcançados laçam luz à premente necessidade de se promover encorajamentos para resistência e sobrevivência à desigualdade e às injustiças sociais.
O USO DE AGROTÓXICOS NA FLORICULTURA: O CASO DE VARGEM ALTA – REGIÃO SERRANA DO RIO DE JANEIRO
Authors: Nascimento Marilia Teresa Lima do , Santos Ana Dalva de Oliveira , Alentejano Paulo Roberto Raposo , Baptista Neto José António , Fonseca Estefan Monteiro da , Bila Daniele Maia 
Published: December 2018

A contaminação por agrotóxicos é uma das maiores preocupações ambientais e de saúde pública na atualidade. Os efeitos desses produtos atingem não só áreas rurais, mas a população como um todo. Vargem Alta, localizada na Região Serrana do Rio de Janeiro, possui tradição na produção de olerícolas e destaque no cultivo de flores como: crisântemos, rosas, palmas, tango, gérberas, entre outras. Este trabalho tem como objetivo avaliar os problemas de saúde por exposição aos agrotóxicos dos trabalhadores na floricultura. A metodologia consistiu na aplicação de um questionário específico para os agricultores, agentes de saúde e técnicos em Vargem Alta e adjacências, para obter dados sobre os principais sintomas relatados. Os resultados demonstraram expressiva utilização de agrotóxicos; fragilidade da fiscalização; descompasso entre as medidas mínimas de segurança; ausência de uso de equipamentos de proteção individual e descarte inadequado de embalagens. Entre os sintomas mais relatados destacam-se: problemas de nervos; endócrinos; neurológicos; respiratórios; hepáticos; alergias; hipertensão; diabetes; diarréias; dores no corpo e vertigens. Nesse sentido, práticas sustentáveis precisam ser estimuladas, com políticas públicas mais efetivas voltadas para lugares e situações de risco por exposição em áreas rurais.
Ovarian cancer
Authors: Peate Ian 
Published: December 2018

Those women with ovarian cancer often present with advanced disease. Ovarian cancer can have a devastating impact on a woman's health and wellbeing. This article provides an overview of the internal female reproductive tract. The incidence and distribution of the condition are provided, along with a discussion of signs and symptoms, diagnosis, identification of risk factors, staging and treatment options. Health promotion is discussed and a conclusion provided. The article emphasises the role of the healthcare assistant (HCA) and the associate practitioner (AP) in offering support to women and their families, as well as raising awareness of the condition. A short test with multiple-choice questions and a glossary of terms are also provided.
Odontogenic Myxoma of the Maxilla: Diagnostic Considerations, Surgical Resection and Prosthetic Rehabilitation
Authors: Gamie Yehya EK , Gamie Zakareya , Seymour David , Whitfield Paul H 
Published: December 2018

A 15-year-old female with a history of orthodontic treatment was referred by her general dental practitioner (GDP) to the Oral and Maxillofacial Surgery (OMFS) department after noticing a right buccal maxillary swelling during a routine check-up. Examination and radiographic investigations revealed a lesion extending from UR3 to UR6 causing bony expansion with no evidence of root resorption. Following biopsy and histopathological analysis, a diagnosis of Odontogenic Myxoma (OM) was made. Treatment involved a segmental resection and fitting an immediate partial denture. Options for long-term rehabilitation include removable and implant-supported prostheses. CPD/Clinical Relevance: This case highlights the importance of thorough clinical and radiographic examination, and joint treatment planning between the Restorative and OMFS departments.
Evaluation of the Non-HDL Cholesterol to Apolipoprotein B Ratio as a Screening Test for Dysbetalipoproteinemia
Authors: Boot Christopher S , Middling Elizabeth , Allen Joy , Neely Robert D G 
Published: December 2018

AbstractBACKGROUNDFamilial dysbetalipoproteinemia is associated with the accumulation of remnant lipoproteins and premature cardiovascular disease. Identification of dysbetalipoproteinemia is important because family members may be affected. Diagnostic testing involves demonstration of β-lipoprotein in the VLDL fraction or characterization of apo E3. These investigations are complex and relatively expensive. The ratios of apo B to total cholesterol and triglycerides have been proposed as screening tests. However, the ratio of non-HDL cholesterol to apo B (NHDLC/apoB) could offer improved performance as the confounding effect of variations in HDL cholesterol is removed.METHODSWe evaluated NHDLC/apoB as a screening test for dysbetalipoproteinemia, using β-quantification analysis as a reference standard. Data from 1637 patients referred over a 16-year period for β quantification were reviewed retrospectively. In 63 patients, diagnostic criteria for dysbetalipoproteinemia (VLDL cholesterol/triglyceride ratio ≥0.69 and presence of β-VLDL) were fulfilled, and 1574 patients had dysbetalipoproteinemia excluded.RESULTSMean NHDLC/apoB in patients with dysbetalipoproteinemia was 7.3 mmol/g (SD, 1.5 mmol/g) and with dysbetalipoproteinemia excluded was 4.0 mmol/g (SD, 0.5 mmol/g). The optimum cutoff of &gt;4.91 mmol/g achieved a diagnostic sensitivity of 96.8% (95% CI, 89.0–99.6) and specificity of 95.0% (95% CI, 93.8–96.0). NHDLC/apoB offered improved performance compared to total cholesterol/apoB [diagnostic sensitivity 92.1% (95% CI, 82.4–97.4) and specificity 94.5% (95% CI, 93.2–95.6) with a cutoff of &gt;6.55 mmol/g]. NHDL/apoB reference ranges were not sex-dependent, although there was a significant difference between men and women for total cholesterol/apoB.CONCLUSIONSNHDLC/apoB offers a simple first-line test for dysbetalipoproteinemia in selecting patients with mixed hyperlipidemia for more complex investigations.
Martyrs, memory and misrepresentation: The Spanish Catholic Church, religious persecution and the Spanish Civil War
Authors: Thomas Maria 
Published: December 2018

Abstract
This article explores the ways in which the victims of anticlerical violence during the Spanish Civil War have been represented and remembered by the Spanish ecclesiastical hierarchy and Catholic hagiographers, examining the period from the Spanish Civil War up to the present day. It sustains that the discourse of martyrdom forged by the Catholic Church during the Civil War and the Dictatorship played a crucial role in legitimating the rebel war effort and the Franco Dictatorship, and in justifying repression against those associated with the Second Republic. It argues that the key tenets of the martyrdom discourse survived the Transition to Democracy and continue to characterize present-day Spanish ecclesiastical discourse. Against this backdrop, a re-evaluation of the Spanish episcopate’s assertions that the martyrs of the Civil War are non-political symbols of reconciliation between Spaniards is necessary.
Post-2008 Spanish migration to Argentina: Just ‘weathering the storm’?
Authors: Miorelli Romina , Manóvil Lara 
Published: December 2018

Abstract
Following the 2008 economic crisis, many Spaniards left their country in search of jobs and opportunities abroad. By 2014, of the more than two million Spaniards living abroad, the majority of those outside the European Union and the United States of America – 400,000 of them – were living in Argentina. By focusing on testimonies published in Argentine and Spanish newspapers and complementing them with an analysis of selected life histories, this article explores whether those migrating from Spain to Argentina were in search of a new home or, rather, of a temporary solution while ‘weathering the storm’. The article argues that the answer is to be found beyond economic factors and shows how these migrants’ decisions and experiences were also strongly shaped by non-economic factors, especially the social networks that had developed out of previous migration waves between Spain and Argentina.
Fernanda Jacobsen and the Scottish Ambulance Unit during the Spanish Civil War (1936–39)
Authors: Palfreeman Linda 
Published: December 2018

Abstract
When Civil War broke out in Spain in July 1936, the Republic made a worldwide plea for humanitarian assistance. Many thousands of people around the world rallied to the call, the Scottish Ambulance Unit among them. The only woman in the twenty-strong team was the unit’s commandant, Fernanda Jacobsen. She would remain at the unit’s helm on each of its successive expeditions to Spain, spanning a period of roughly two years, from September 1936 to July 1938. Despite its tremendous and sustained humanitarian contribution in and around the besieged Spanish capital of Madrid, the Scottish unit has not received the recognition afforded similar enterprises in the now vast literature on the Spanish Civil War. This article will examine the possible reasons for this. It will discuss previously unexplored documentary evidence and re-examine existing records in an attempt to shed light on the causes of internal struggles in the unit that led, eventually, to the resignation of some of its members.
The beach as microcosm of a cosmopolitan city: Imagining and experiencing urban encounters at Trieste’s Pedocin beach
Authors: van Hout Milou 
Published: December 2018

Abstract
This article focuses on the nature of beaches as places of urban encounters, critically examining the cosmopolitanized discourse of Trieste’s urban identity by exploring the dynamics of urban ‘world-making’ at Trieste’s Pedocin beach. The analysis focuses on the ways in which the recent documentary L’Ultima Spiaggia (The Last Resort) (Anastopoulos and Del Degan, 2016) moves away from the poetic elite imaginations that have fashioned cultural narratives of Trieste. The film represents a cosmopolitan experience, which, for Trieste’s beachgoers, is not enclosed in the moment of encounter with diversity and the other. Cosmopolitanism, here, is rather the individual capacity to live between the overlapping urban realities that the triestini inhabit, and yet within their own internal moment.
Of ‘Godziners’ and ‘Designer Citizens’: The emergence of designers as political subjects in Cape Town
Authors: Nkula-Wenz Laura 
Published: December 2018

Abstract
Over the course of 2011, the City of Cape Town bid for, and eventually won the title of World Design Capital 2014. This article discusses how the ‘idea of design’ emerged as a new governmental rationality and mode of subjectivation, positing the local ‘design community’ as an indispensable macro-actor of local development and policy production. It unpacks the various (self-)ascriptions and socio-economic aspirations pinned to the notion of design and its actionable subjectivity, the designer. While recognizing that the idea of design has raised hopes for innovative solutions that could help to address Cape Town’s most pervasive urban challenges, the article ultimately questions whether real change ‘by design’ can be attained without designers acknowledging and (self-)critically engaging with the political dimension of their work.
Mobile worlding: Exploring the trans-urban circulation and the interconnectedness of migrants’ urban world-making practices
Authors: Beeckmans Luce 
Published: December 2018

Abstract
This short-form article considers the concept of ‘mobile worlding’ in relation to migrants’ world-making practices. Yet, instead of the conventional focus on the transnational cultural exchange between migrants’ home and host countries, this article theorizes the trans-urban circulation and interconnectedness of migrants’ urban world-making practices across cities in Europe. It reflects on how migrants’ urban world-making practices may be conceptualized as ‘practices of citation and reference in a world of inter-connected urbanism’ or a ‘mobile urbanism’ from below (McCann et al. and McCann and Ward). In this article, examples of urban world-making practices of African diaspora are discussed, highlighting the author’s own research on religious place-making in European cities, as well as other instances of ‘mobile worlding’ that are not yet conceptualized as such, for instance hip-hop and fashion.
Indigenous radio and digital media: Tautoko FM’s national and transnational audiences
Authors: de Bruin Joost , Mane Jo 
Published: December 2018

Abstract
In this article, we posit that Māori radio as it is structured in Aotearoa/New Zealand is at the same time national, international and transnational. Based on a research project that we carried out with the radio station Tautoko FM, we show that this station caters for national Ngāpuhi audiences, that it engages in international networking with other iwi-based radio stations and that it has invested in transnational connections with diasporic audiences. As a result, it has constructed a public sphere for both national and transnational indigenous audiences. This is facilitated by the changing nature of radio as a medium, which is evolving into a multimedia experience incorporating broadcasting, live streaming, websites and social media. Māori radio in Aotearoa/New Zealand is one example of a global trend in which indigenous communities have adapted new media technologies to re-centre notions of national identity. The digital media landscape allows them to form indigenous media networks, to narrate indigenous experiences in new ways and to acquire attention for indigenous struggles.
The Heideggerian critique of Kant’s moral subject
Authors: Tóth Gábor 
Published: December 2018

The paper discusses Kant’s concept of the subject through Heideger’s critique. Heidegger deconstructs the structure of Kant’s idea of personal identity as the moral subject. In the 13th paragraph of The Basic Problems of Phenomenology (1927), Heidegger distinguishes three basic aspects of Kant’s idea of the self: the personalitas transcendentalis, the personalitas psychologica, and the personalitas moralis. The personalitas moralis is defined as the sphere of pure morality, the intelligible realm of freedom. This is an aspect of the individual beyond physical features and also beyond the determinism of laws of nature. The causality by freedom forms the basis of practical actions ordered by moral law. Therefore, it acts as the highest level determinism of Being in human existence. Heidegger’s conclusion shows Kant’s failure in delineating a functional model of the moral subject but accepts Kant’s contribution to laying the foundations of such a theory.
The mystique of the self in German preromanticism
Authors: Tánczos Péter 
Published: December 2018

The paper surveys the extent of the connection between German idealism and Preromanticism on the one hand, and Medieval mysticism on the other. For the Romantic model of identity and subjectivity in Novalis and Schlegel, Fichte’s idealist position remains a starting point, as changes of terminology and approach have changed the way the Self was articulated very considerably.
This shift in meaning is the beginning of Romanticism, but despite its significance, the change has its precursors. The desire towards the absolute, the shifting value of religious experience, positing identity without objectification are all positions that can already be found in Medieval thinkers like Eckhardt and Böhme. In some cases, one can even locate a direct connection. The paper focuses on how the connection between Medieval philosophers’ paradox ideas on non-being and emptiness relate to theories of the self in preromantic authors.
The prophet and divine vision in Raffaello’s art. Daniel Arasse: Raffaello’s Visions.
Authors: Vörös Lilla 
Published: December 2018

The prophet and divine vision in Raffaello’s art. Daniel Arasse: Raffaello’s Visions. (Review)

Arasse, Daniel: Raffaello’s Visions. Trans. Pataki Pál. Budapest, Typotex, 2013.
The unity of the broken whole – Sajó Sándor, Almost Everything: the dialectics of broken totality.
Authors: Tóth Gábor 
Published: December 2018

The unity of the broken whole – Sajó Sándor: Almost Everything: the dialectics of broken totality. (Review)
Sajó Sándor: Almost Everything: the dialectics of broken totality. Budapest, L’Harmattan, 2014. pp. 174.