bluuebunny/crossref_metadata_2025_split huggingface dataset:
Adaptación del Cuestionario para Identificación de Trastornos Debidos al Consumo de Alcohol (AUDIT) en universitarios colombianos.
Authors: Riveros Fernando , Vera Luis A. , Gantiva Carlos , Torres Leidy 
Published: February 2019

Abstract: Adaptation of the Alcohol Use Disorders Identification Test (AUDIT) in Colombian university students. Although alcohol consumption is one of the behaviors that generates more negative consequences for public health, there are few validated instruments that allow to measure alcohol consumption in Colombian population. The objective of the present investigation was to adapt the Alcohol Use Disorders Identification Test (AUDIT) in a sample of Colombian university students. The method used was instrumental, because the questionnaire was submitted to the technical adaptation process defined by WHO. It was applied to a sample of 1,557 Colombian university students, selected under a probabilistic procedure. The results showed that the scale (a) has adequate clarity in its language, (b) fits a well-defined two-factor model, (c) has good levels of reliability (internal consistency) and positive correlations between the items. It was concluded that the AUDIT is a tool with sound psychometric properties to be used in Colombian university students.Resumen: El consumo de alcohol es una de las conductas que genera mayores problemáticas para la salud pública, pero son escasos los instrumentos validados que permiten medirlo en población colombiana. El objetivo de la presente investigación fue adaptar el Cuestionario para Identificación de Trastornos Debidos al Consumo de Alcohol (AUDIT) en universitarios colombianos. El método utilizado fue instrumental, dado que el cuestionario fue sometido al proceso técnico de adaptación definido por la OMS. Se aplicó a una muestra de 1.557 universitarios colombianos, seleccionados bajo un procedimiento probabilístico. Los resultados mostraron que la escala (a) posee claridad adecuada en su lenguaje, (b) se ajusta a un modelo de dos factores bien definidos, y (c) posee buenos niveles de fiabilidad (consistencia interna) y correlaciones positivas entre los reactivos. Se concluye que el AUDIT es un instrumento con propiedades psicométricas apropiadas para ser utilizado en universitarios colombianos.
Los tejidos reticulares: alianzas y solidaridades empresariales en la territorialización del modelo de agronegocios (Córdoba, Argentina)
Authors: Ambrogi Sofía 
Published: February 2019

Las discusiones en torno a las transformaciones en el agro, producto de innovaciones biotecnológicas, el aumento del precio de los commodities a nivel internacional y las reformas políticas y económicas en diferentes países latinoamericanos, ha sido ampliamente trabajado en estos últimos años desde diversos campos disciplinares. Dada esta preponderancia de las transformaciones rurales en Argentina como objeto de estudio en la academia, este dossier convoca a repensar la ruralidad como objeto de reflexión desde las ciencias sociales, prestando particular atención a las especificidades que asumen estos cambios en prácticas y experiencias rurales concretas. En ese sentido, este trabajo se pretende sumar a las discusiones que plantean tensiones en las visiones dicotómicas respecto a lo rural y lo urbano como territorios diferenciados y diferenciables. Dado que el modelo de agronegocios plantea configuraciones reticulares entre acciones estatales, intervenciones desde las empresas y asociaciones técnicas del agro, y las comunidades locales urbanas, es necesario prestar atención a los proyectos y acciones solidarias desarrollados por actores empresariales del agro, desde los cuales apuntan a construir narrativas sobre la ruralidad, el desarrollo productivo, la sustentabilidad y la responsabilidad social. Se apunta a entender cómo se construye legitimación social del modelo de agronegocios en centros urbanos y ciudades de Córdoba, Argentina, desde las intervenciones empresariales de una asociación técnica del agro.
Four approaches to using patients to teach and evaluate clinical skills of residents, interns, and students
Authors: Mediom Franklin J. , Morewitz Stephen J. 
Published: February 2019

Abstract
As osteopathic medical educators look for ways to enhance their training programs in a fiscally responsible manner, previously underused training methods deserve a second look. This article presents four ways that patients can serve as teachers and evaluators of residents' and students' clinical skills.
Irritable bowel syndrome
Authors: Moscatello Salvatore A. , Cheskin Lawrence J. 
Published: February 2019

Abstract
The irritable bowel syndrome is a common disorder of gastrointestinal motility. Abdominal pain, bloating, and inconsistent bowel habits are the hallmark symptoms of irritable bowel syndrome. Fever, weight loss, and gastrointestinal bleeding often indicate more serious pathologic gastrointestinal conditions, such as inflammatory bowel disease or infectious enteritis. Because irritable bowel syndrome is so prevalent in our society, the primary care physician should be able to readily recognize the clinical features of this disorder in order to spare patients expensive, unnecessary diagnostic and therapeutic interventions. In this review, the authors discuss the clinical and psychological features of irritable bowel syndrome and offer a useful approach to the diagnosis and treatment of this disorder.
Lyme disease
Authors: Hedayati Hadi 
Published: February 2019

Abstract
Lyme disease, a multisystem disorder, has now been reported to the Centers for Disease Control from 43 states of the United States. The disease is a ticktransmitted infectious disorder caused by the spirochete bacterium Borrelia burgdorferi. Lyme disease typically begins with the symptoms of flu associated with a characteristic skin rash, erythema chronicum migrans. The diagnosis of Lyme disease is best made by clinical examination and epidemiologic history, with serologic studies supporting the clinical diagnosis. Prompt diagnosis and early treatment with antibiotics will often lead to the resolution of symptoms and the prevention of late complications, Lyme carditis, neurologic manifestations, and arthritis.
Choriocarcinoma of the kidney
Authors: Mack Richard B. , Katz Sheila M. , Amenta, Peter S. 
Published: February 2019

Abstract
Choriocarcinoma is a malignant germ cell tumor that usually arises from a previous gestation, but may also arise from germ cells anywhere along their known migratory pathway during fetal development. Gestational choriocarcinoma is highly sensitive to chemotherapy. This malignancy is known to undergo spontaneous regression of the primary tumor, which, in the face of metastases, may obscure the primary tumor site. The authors report the case of a patient with choriocarcinoma who was seen with pulmonary metastases and a single large lesion in the kidney 5 years posthysterectomy. The problems in resolving the primary site and the importance of a tissue diagnosis before nephrectomy are discussed.
Anomalous origin of the left main coronary artery from the right anterior aortic sinus
Authors: Waters Daniel J. , Kimm Kevin A. , Stanley WIlliam E. , Reeder James T. , Hoff Gary 
Published: February 2019

Abstract
Anomalous origin of the left main coronary artery from the right sinus of Valsalva is an uncommon problem, occurring in four distinct patterns. When the left main coronary artery passes between the aorta and the pulmonary trunk, acute myocardial ischemia or sudden death may occur. Angiography is required in establishing a diagnosis. Surgical correction or bypass surgery are sometimes indicated. The authors report two cases of anomalous origin of the left main coronary artery and discuss the anatomic variants, clinical significance, and technical considerations in both diagnosis and management.
A new perspective on stress ulcer prophylaxis
Authors: Sing Ronald F. , Marino, Paul L. 
Published: February 2019

Abstract
Gastric acid suppression by use of either antacids or histamine H2-receptor antagonist therapy is the mainstay of stress ulcer prophylaxis. Available evidence indicating an antimicrobial role for gastric acid calls for the reevaluation of gastric acid suppression. A pH of greater than 4.0 leads to bacterial overgrowth and colonization of the upper gastrointestinal tract which has been associated with nosocomial pneumonia, bacterial translocation from the gut, systemic sepsis, and. multiple-organ failure. The availability of alternative therapy should discourage the routine use of acid-suppression therapy in the critically ill patient.
Suggestions for clinicians providing--and residents seeking--feedback
Authors: Sprafka Sarah 
Published: February 2019

Abstract
As a form of verbal or nonverbal communication intended to promote learning, feedback plays an important role in the medical training process. More often than not, however, feedback is given-and received-inappropriately by both clinicians and residents, respectively. This article outlines common types of instructional feedback, their inherent advantages and disadvantages, and suggests ways in which clinicians and residents may incorporate feedback effectively in a residency/training program.
Cerebral emboli from the 'stump' of a totally occluded carotid artery: Surgical management
Authors: Waters Daniel J. , Stanley William E. 
Published: February 2019

Abstract
The obstructing thrombus in a totally occluded internal carotid artery may act as a source of cerebral emboli. These emboli traverse the external carotid and ophthalmic arteries and enter the intracranial circulation via retrograde collateral pathways. Surgical treatment can result in complete abatement of symptoms in selected patients. The authors describe internal carotid "stump" syndrome in a 47year-old man and discuss the options for surgical management.
Clinical improvement of the myopathy in eosinophilia-myalgia syndrome with steroids and rehabilitative therapy
Authors: Nigro Michael A. , Esper Jeffrey J. , Ba Robin Wishnow, , Barnett Thomas , Perrotta Augustine L. , Richardson WIlliam 
Published: February 2019

Abstract
The authors report a case of eosinophilia-myalgia syndrome with a progressive neuromyopathy. Progressive weakness, myalgia, and dermatitis developed in the patient described after chronic ingestion of high-dose L-tryptophah for insomnia. Laboratory, electrophysiologic, and muscle biopsy results support the diagnosis of an inflammatory myopathy consistent with that of eosinophilia-myalgia syndrome. The patient's weakness led to wheelchair dependency. A review of the literature regarding this disorder shows inconsistent results with steroid and other modes of therapy. After a course of high-dose steroids with long-term tapering and vigorous inpatient and outpatient rehabilitation, the patient was able to walk and function independently within 2 months.
Alleviating stress in residency training through enhanced communication: A practical guide
Authors: Bost Richard H. 
Published: February 2019

Abstract
Stress is an inherent component of residency training and its effect on healthcare provided is well documented. Although stress-related signs and symptoms are easily recognized, residents and trainers are likely to ignore them-until a crisis occurs. Based on the theory that good communication alleviates stress, the "I" Language Model, discussed in this article, is designed to enhance communication between residents and their superiors, colleagues, and families. As such, it is meant to provide one means of intervention before stress affects the resident's on-the-job performance.
Genetic alteration of histone lysine methyltransferases and their significance in renal cell carcinoma
Authors: Yan Libin , Zhang Yangjun , Ding Beichen , Zhou Hui , Yao Weimin , Xu Hua 
Published: February 2019

BackgroundHistone lysine methyltransferases (HMTs), a category of enzymes, play essential roles in regulating transcription, cellular differentiation, and chromatin construction. The genomic landscape and clinical significance of HMTs in renal cell carcinoma (RCC) remain uncovered.MethodsWe conducted an integrative analysis of 50 HMTs in RCC and discovered the internal relations among copy number alterations (CNAs), expressive abundance, mutations, and clinical outcome.ResultsWe confirmed 12 HMTs with the highest frequency of genetic alterations, including seven HMTs with high-level amplification, two HMTs with somatic mutation, and three HMTs with putative homozygous deletion. Patterns of copy number and expression varied among different subtypes of RCC, including clear cell renal cell carcinoma, papillary cell carcinoma, and chromophobe renal carcinoma. Kaplan–Meier survival analysis and multivariate analysis identified that CNA or mRNA expression in some HMTs were significantly associated with shorter overall patient survival. Systematic analysis identified six HMTs (ASH1L, PRDM6, NSD1, EZH2, WHSC1L1, SETD2) which were dysregulated by genetic alterations as candidate therapeutic targets.DiscussionIn summary, our findings strongly evidenced that genetic alteration of HMTs may play an important role in generation and development of RCC, which lays a solid foundation for the mechanism for further research in the future.
SCOUR MECHANISM INDUCED BY PROPELLER FLOW NEAR A QUAY WALL
Authors: Yuksel Yalcin , Tan Ilayda , Celikoglu Yesim , Atik Taha 
Published: February 2019

Increasing ship dimensions in recent years cause structural instability due to the scouring problem during berthing and unberthing maneuver of the vessels.
The propeller jet has 3D flow area and high velocities that may cause erosion problem around the berthing structures in three ways. These are; a) On a slope, b) At the toe of vertical wall, c) Around piles.
In general scour problems are investigated by using physical modeling. Propeller jet induced the scour in front of the wall has been well studied in the past (Hamill et al. (1999), Ryan et al. (2013(a)), Ryan et al. (2013(b))).
In this study, propeller jet flow was considered to investigate the seabed scour mechanism with and without vertical quay wall conditions and their comparisons were made. Three different distances of the propeller from the wall at Xw=0.7 m, 0.35 m and 0.175 m were tested for different clearances at G=0.1 m and 0.15 m on sand bed of d50=0.052 mm to give an extensive definition for scour depth estimation.
STATISTICAL DISTRIBUTION OF WAVE HEIGHTS IN CORRELATION WITH ENERQ7 SPECTRUM AND WATER DEPTH
Authors: Koele L.A. , De Bruyn P.A. 
Published: February 2019

Wave motion has been studied at various places in the south western part of the Netherlands (the Delta area) as part of a study on coastal morphology and the design of coastal structures. The main part of this study deals with the statistical distribution of wave heights in relation to: a. the height of the sea surface at fixed points, as a function of time; b. the water depth; c. the energy spectrum of the wave motion. The results of theoretical studies by D.E.Cartwright and M.S.Longuet Higgins (lit. 1) and data on wave measurements obtained by Rijkswaterstaat in the North Sea were used. These measurements were taken by means of an electrical step-capacity gauge, with wireless
transmission of the data to shore . Three gauges, fastened to fixed poles (named E, X and T) were placed at points at depths of 5, 10 and 15 meters respectively, (fig. 1).
An autophagy‐related long non‐coding RNA signature for glioma
Authors: Luan Fangkun , Chen Wenjie , Chen Miao , Yan Jun , Chen Hao , Yu Haiyue , Liu Tieqi , Mo Ligen 
Published: February 2019

Glioma is one of the most common types of malignant primary central nervous system tumor, and prognosis for this disease is poor. As autophagic drugs have been reported to induce glioma cell death, we investigated the potential prognostic role of autophagy‐associated long non‐coding RNA (lncRNA) in glioma patients. In this study, we obtained 879 lncRNAs and 216 autophagy genes from the Chinese Glioma Genome Atlas microarray, and found that 402 lncRNAs are correlated with the autophagy genes. Subsequently, 10 autophagy‐associated lncRNAs with prognostic value (PCBP1‐AS1, TP53TG1, DHRS4‐AS1, ZNF674‐AS1, GABPB1‐AS1, DDX11‐AS1, SBF2‐AS1, MIR4453HG, MAPKAPK5‐AS1 and COX10‐AS1) were identified in glioma patients using multivariate Cox regression analyses. A prognostic signature was then established based on these prognostic lncRNAs, dividing patients into low‐risk and high‐risk groups. The overall survival time was shorter in the high‐risk group than that in the low‐risk group [hazard ratio (HR) = 5.307, 95% CI: 4.195–8.305; P < 0.0001]. Gene set enrichment analysis revealed that the gene sets were significantly enriched in cancer‐related pathways, including interleukin (IL) 6/Janus kinase/signal transducer and activator of transcription (STAT) 3 signaling, tumor necrosis factor α signaling via nuclear factor κB, IL2/STAT5 signaling, the p53 pathway and the KRAS signaling pathway. The Cancer Genome Atlas dataset was used to validate that high‐risk patients have worse survival outcomes than low‐risk patients (HR = 1.544, 95% CI: 1.110–2.231; P = 0.031). In summary, our signature of 10 autophagy‐related lncRNAs has prognostic potential for glioma, and these autophagy‐related lncRNAs may play a key role in glioma biology.
Water‐Soluble Conjugated Molecule for Solar‐Driven Hydrogen Evolution from Salt Water
Authors: Yang Xiye , Hu Zhicheng , Yin Qingwu , Shu Chang , Jiang Xiao‐Fang , Zhang Jie , Wang Xiaohui , Jiang Jia‐Xing , Huang Fei , Cao Yong 
Published: February 2019

AbstractPhotocatalytic hydrogen evolution is an attractive method for the acquisition of clean and sustainable energy with the use of solar power. Most reported studies have been carried out in scarce pure water. Therefore, the development of an artificial photosynthesis system that works perfectly with the earth's abundant seawater would be attractive. Herein, a supramolecular strategy for photocatalytic hydrogen production from the simulated seawater under sunlight irradiation (AM 1.5G, 100 mW cm−2) is presented using a water‐soluble, conjugated molecule as the photosensitizer and the photodeposited Pt nanoparticles as the catalyst. Inspired by the natural photosynthesis system, unprecedented advantage of the chloride ions in seawater is taken and the formation of supramolecular structure is promoted by electrostatic interactions between chloride ions and the fine‐designed PorFN, which further facilitates the loading of Pt nanoparticles and multielectron transfer. As a result, a hydrogen evolution rate of 10.8 mmol h−1 g−1 is achieved in the simulated seawater. Moreover, the photocatalytic activity shows relatively low dependence on the light intensity, which is of great importance for practical applications.
An Anisotropically High Thermal Conductive Boron Nitride/Epoxy Composite Based on Nacre‐Mimetic 3D Network
Authors: Han Jingkai , Du Gaolai , Gao Weiwei , Bai Hao 
Published: February 2019

AbstractPolymer‐based thermal interface materials (TIMs) with excellent thermal conductivity and electrical resistivity are in high demand in the electronics industry. In the past decade, thermally conductive fillers, such as boron nitride nanosheets (BNNS), were usually incorporated into the polymer‐based TIMs to improve their thermal conductivity for efficient heat management. However, the thermal performance of those composites means that they are still far from practical applications, mainly because of poor control over the 3D conductive network. In the present work, a high thermally conductive BNNS/epoxy composite is fabricated by building a nacre‐mimetic 3D conductive network within an epoxy resin matrix, realized by a unique bidirectional freezing technique. The as‐prepared composite exhibits a high thermal conductivity (6.07 W m−1 K−1) at 15 vol% BNNS loading, outstanding electrical resistivity, and thermal stability, making it attractive to electronic packaging applications. In addition, this research provides a promising strategy to achieve high thermal conductive polymer‐based TIMs by building efficient 3D conductive networks.
A Photo‐Crosslinkable Kidney ECM‐Derived Bioink Accelerates Renal Tissue Formation
Authors: Ali Mohamed , PR Anil Kumar , Yoo James J. , Zahran Faten , Atala Anthony , Lee Sang Jin 
Published: February 2019

Abstract3D bioprinting strategies in tissue engineering aim to fabricate clinically applicable tissue constructs that can replace the damaged or diseased tissues and organs. One of the main prerequisites in 3D bioprinting is finding an appropriate bioink that provides a tissue‐specific microenvironment supporting the cellular growth and maturation. In this respect, decellularized extracellular matrix (dECM)‐derived hydrogels have been considered as bioinks for the cell‐based bioprinting due to their capability to inherit the intrinsic cues from native ECM. Herein, a photo‐crosslinkable kidney ECM‐derived bioink (KdECMMA) is developed that could provide a kidney‐specific microenvironment for renal tissue bioprinting. Porcine whole kidneys are decellularized through a perfusion method, dissolved in an acid solution, and chemically modified by methacrylation. A KdECMMA‐based bioink is formulated and evaluated for rheological properties and printability for the printing process. The results show that the bioprinted human kidney cells in the KdECMMA bioink are highly viable and mature with time. Moreover, the bioprinted renal constructs exhibit the structural and functional characteristics of the native renal tissue. The potential of the tissue‐specific ECM‐derived bioink is demonstrated for cell‐based bioprinting that could enhance the cellular maturation and eventually tissue formation.
Fabrication of Large‐Area Bimodal Sensors by All‐Inkjet‐Printing
Authors: Fu Sheng , Tao Juan , Wu Wenqiang , Sun Junlu , Li Fangtao , Li Jing , Huo Zhihao , Xia Zhiguo , Bao Rongrong , Pan Caofeng 
Published: February 2019

AbstractElectronic skin (e‐skin) is a wearable smart terminal that senses changes of external environment like human skin. It will develop into an indispensable way of interaction between humanity and technology. Here, this bimodal e‐skin that senses bending strain and pressure using an all‐inkjet‐printing method is synthesized. It is based on a microcracked metal film and a sandwich capacitor structure. It is characterized by the metal film of the strain sensor as a bottom electrode of pressure sensor; the electrode plate of the device plays a dual role. When tested, the strain sensor and pressure sensor do not interfere with each other. The device has excellent performance with low pressure‐detection of 2 Pa and high stability over more than 5700 cycles for pressure sensor and high gauge factor (4000) and good stability (over 4500 cycles) for strain sensor, which can recognize the radius of curvature of human activities and objects, and can detect the pressure distribution and the curvature of irregular surfaces, showing its potential applications in wearable devices.