bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exploring Writer’s Block as Embodied Experience Across the Grades
Authors: Enriquez Grace , Vaughan Andrea 
Published: December 2024

Background or Context: The notion of writer’s block has been primarily conceived and explored as a breakdown in a cognitive writing process (Rose, 1984); yet, for many writers, confronting writer’s block often involves engaging the body through sensations, feelings, movement, and action. However, these considerations have not yet impacted our understanding of writer’s block in the field of literacy education. Given how attention to bodies and theories of embodiment have broadened considerations of literacies, we approach writing and writing processes (including not being able to write) as similarly embodied. Purpose, Objective, Research Question, or Focus of Study: Our purpose is to theorize writer’s block not only as a cognitive phenomenon, but also as an embodied one, and to offer that conceptualization for use in literacy theory, research, and practice. We ultimately argue that viewing writer’s block as an embodied phenomenon opens up possibilities for understanding writer’s block as not only restrictive, but also potentially generative, and can reframe understandings of “struggling” writers. Research Design: Drawing from our research across grades K–12, as well as our own experiences as writers, we present vignettes from elementary, middle school, high school, and adult contexts to illustrate how viewing writer’s block as embodied produces a more nuanced understanding of writers’ experiences. Moreover, because we engaged different research designs and methods for each study, we sought to “think with theory” (Jackson & Mazzei, 2012) across our work, rather than select a traditional qualitative analysis approach that might not have made visible the connections and nuances we sensed. These data and reflections are not intended to serve as complete, standalone case studies, but rather as illustrative examples to clarify our points. Conclusions or Recommendations: A more robust conception of writer’s block as something that is multidimensional (cognitive, social, cultural, affective, embodied, etc.) may allow for a fuller discussion of writing processes, as well as counter deficit assumptions of writers who appear to be “struggling,” including, in particular, Black, Indigenous, and students of color; disabled students; English learners; and other students who tend to be marginalized in official writing classroom contexts. Central to our framework are the following principles: (1) Bodies are an important medium through which writer’s block is recognized and expressed. (2) Writer’s block is socially co-constructed. (3) Writer’s block constitutes an intra-action with the human and nonhuman aspects of writing. (4) Despite appearing “stuck” or off-task, writers’ bodies are constantly charged with energy and possibility. With implications for practice and further research, this framework repositions writer’s block for students, teachers, and researchers from a deficit or remedial issue to an experience of writerly engagement, productivity, and possibility.
Co-production in practice: A qualitative study of the development of advance care planning workshops for South Asian elders
Authors: Clabburn Oliver , Stone Tracey , Anwar Naheed , Saleem Taskin , Khan Salim , Hewat Verena , Grieve Usha , Dawson Lesel , Farr Michelle , Redwood Sabi , Selman Lucy E 
Published: December 2024

Background: Advance care planning can improve patient and family outcomes; however, minoritised ethnic communities experience access barriers. Co-production offers a way to design culturally appropriate information and support, but evidence is needed to understand its implementation in palliative care. Aim: To explore and describe how two charities used co-production to develop and deliver community-based advance care planning workshops for South Asian elders. Design: Workshops were co-produced by two charities. In parallel, a multi-component qualitative study was conducted comprising workshop observations, semi-structured interviews with charity staff and focus groups with workshop participants, facilitated by community co-researchers in English, Hindi, Urdu and Punjabi. Data were analysed using thematic analysis. Setting/participants: Four workshops were held in a London (UK) community setting (each with 5–30 participants); four interviews were conducted with charity staff members, and three focus groups with 16 workshop participants. Results: We describe three main themes: Co-production in action: organic origins and trusted foundations; Co-production processes embedded in equal partnership; and Impact of the workshops. Fundamental to co-production processes was the community-led approach of the local charity, the trust of the local South Asian community and the relationship between the charities, including transparent communication and mutual respect. The workshops were reported to be useful and enjoyable, engendering a sense of agency and connection and helped disseminate awareness and knowledge through the community, benefitting the wider system. Conclusions: Co-production can help widen access to advance care planning. Findings offer an in-depth example of co-production-in-action to inform intervention development and research.
Effect of preventive treatment with atogepant on quality of life, daily functioning, and headache impact across the spectrum of migraine: Findings from three double-blind, randomized, phase 3 trials
Authors: Gottschalk Christopher , Gandhi Pranav , Pozo-Rosich Patricia , Christie Suzanne , Tassorelli Cristina , Stokes Jonathan , Liu Yingyi , Luo Lei , Nagy Krisztian , Trugman Joel M. , Lipton Richard B. 
Published: December 2024

Background We aimed to assess the effects of preventive migraine treatment with atogepant vs. placebo on patient-reported quality of life and functioning. Methods Analyses of patient-reported outcomes from three 12-week, randomized, placebo-controlled trials evaluating preventive migraine treatment with atogepant 60 mg once-daily: ADVANCE (low-frequency episodic migraine [LFEM], 4–8 monthly migraine days [MMDs] and high-frequency episodic migraine [HFEM], 8–14 MMDs), PROGRESS (chronic migraine, CM) and ELEVATE (episodic migraine in those previously failed by two to four classes of oral preventive treatments). Results Least squares mean differences (95% confidence interval (CI)) in change from baseline were greater ( p < 0.05) for atogepant vs. placebo for Migraine-Specific Quality of Life questionnaire Role Function–Restrictive domain scores at week 12 (ADVANCE: LFEM 12.0 (95% CI = 6.0–18.0), HFEM 9.9 (95% CI = 3.4–16.4); PROGRESS: 6.2 (95% CI = 2.5–9.8); ELEVATE: 17.7 (95% CI = 13.1–22.3)), for Headache Impact Test-6 total scores at week 12 (ADVANCE: LFEM −4.7 (95% CI = −6.7 to −2.7); HFEM −3.4 (95% CI = −5.5 to −1.2); PROGRESS: −2.8 (95% CI = −4.1 to −1.4); ELEVATE: −6.5 (95% CI = −8.3 to −4.7)) and for Activity Impairment in Migraine–Diary-Performance of Daily Activities scores across 12 weeks (ADVANCE: LFEM −2.3 (95% CI = −3.9 to −0.7), HFEM −4.5 (95% CI = −6.9 to −2.2); PROGRESS: −3.4 (95% CI = −5.3 to −1.5); ELEVATE: −4.7 (95% CI = −6.4 to −3.1)). Conclusions Preventive migraine treatment with atogepant 60 mg once-daily vs. placebo improved measures of migraine-related quality of life and functioning among participants with different headache frequencies and histories of previous treatment failure. Trial Registration: ClinicalTrials.gov: NCT03777059 (ADVANCE); NCT03855137 (PROGRESS); NCT04740827 (ELEVATE)
Surgical planning in HTO – alternative approaches to the Fujisawa gold-standard
Authors: Komnik Igor , Funken Johannes , Zachow Stefan , Schmidt-Wiethoff Rüdiger , Ellermann Andree , Potthast Wolfgang 
Published: December 2024

Background Presurgical planning of the correction angle plays a decisive role in a high tibial osteotomy, affecting the loading situation in the knee affected by osteoarthritis. The planning approach by Fujisawa et al. aims to adjust the weight-bearing line to achieve an optimal knee joint load distribution. While this method is accessible, it may not fully consider the complexity of individual dynamic knee-loading profiles. This review aims to disclose existing alternative HTO planning methods that do not follow Fujisawa's standard. Methods PubMed, Web of Science and CENTRAL databases were screened, focusing on HTO research in combination with alternative planning approaches. Results Eight out of 828 studies were included, with seven simulation studies based on finite element analysis and multi-body dynamics. The planning approaches incorporated gradual degrees of realignment parameters (weight-bearing line shift, medial proximal tibial angle, hip-knee-ankle, knee joint line orientation), simulating their effect on knee kinematics, contact force/stress, Von Mises and shear stress. Two studies proposed implementing individual correction magnitudes derived from preoperatively predicted knee adduction moments. Conclusion Most planning methods depend on static alignment assessments, neglecting an adequate loading-depending profile. They are confined to their conceptual phases, making the associated planning methods unviable for current clinical use.
Trimethylamine-N oxide enhances post-stroke depression progression via ROS-p38/MAPK signaling
Authors: Hu Yikui , Liu Yujie , Wang Hua , Wang Xun 
Published: December 2024

Introduction Post-stroke depression (PSD) is one of the common complications after stroke. Trimethylamine-N oxide (TMAO) has been reported to exacerbate brain injury after ischemic stroke, and its expression is positively related to the severity of depressive symptoms. This study was performed to investigate the role and mechanism of TMAO in PSD. Methods The classical stroke model was combined with spatial constraint stress to establish a PSD mouse model, and the effect of TMAO on the depression-like behavior of the PSD mouse model was evaluated using the tail suspension test and the forced swimming test. ELISA was employed to measure the concentration of TMAO and cortisol. RT-qPCR, Western blot, and Immunohistochemistry assay were implemented to determine mRNA and protein expression. Endothelial permeability was assessed using the fluorescein isothiocyanate-dextran permeability assay in vitro. Reactive oxygen species (ROS) level was examined with a ROS detection kit. Results TMAO dose-dependently exacerbated depression-like behavior, induced the activation of the p38/mitogen-activated protein kinase (MAPK) signaling pathway, downregulated the abundance of tight junction proteins, and resulted in the dysregulation of neurotrophic mediators in the PSD mouse model in vivo. Further, TMAO increased endothelial permeability and activated reactive oxygen species-p38/MAPK signaling. By introducing the p38/MAPK pathway inhibitor SB203580, TMAO was found to downregulate the expressions of tight junction proteins and promoted endothelial permeability via p38/MAPK signaling activation. Discussion By activating the ROS-P38/MAPK pathway, TMAO enhanced the permeability of the blood–brain barrier after stroke. These mechanisms resulted in the dysregulation of neurotrophic mediators, ultimately leading to PSD progression.
The Psychological Effects of Guillain-Barré Syndrome: A Grounded Theory Study
Authors: Bell Katie , Summers S. J. , Moffitt Jenna , Hill Geoff 
Published: December 2024

Guillain–Barré syndrome is a rare neurological condition. Research has increased our understanding of the etiology, prognosis, and effective medical treatment of the illness. There is a lack of understanding regarding the psychological effects and what could help patients. This study aimed to begin to address this using constructivist grounded theory. Eleven interviews were conducted with participants who had received a diagnosis of Guillain–Barré syndrome in the preceding 4 years. The model that emerged identified two key processes: “Loss, determination, and adjustment” and “The unknown.” “Receiving support,” “Obtaining knowledge,” and “Experiencing hope” assist in navigating these psychological effects. The findings emphasize the all-encompassing effects of Guillain–Barré syndrome, illustrating the need for rehabilitation professionals to alleviate uncertainty and foster practices that could facilitate patients’ navigation through the illness. Recommendations for further research are provided.
Exploring the Correlation Between Palliative Care Training in Brazil and Compassion Fatigue: A Cross-Sectional Study
Authors: Lucio Gabriela Vieira , Rodrigues de Oliveira Lima Gabriela , Dias Faustino Ana Júlia , Alvarez Camila Wenceslau , Marangoni Eliana , Cruvinel Agnes , Cruvinel Thiago , Corrêa da Costa Ribeiro Sabrina , Garcia Alencar Julio Cesar 
Published: December 2024

Background The literature lacks conclusive evidence regarding whether palliative care training confers a protective or predisposing influence on compassion fatigue. The present study hypothesizes that training in palliative care is associated with minor compassion fatigue levels among physicians and an improvement in their confidence in several procedures. Aim To explore the physicians experiences with and without palliative care training who work as general practitioners in order to assess the prevalence of compassion fatigue in these groups. Methods This is a quantitative and qualitative cross-sectional survey. For data analysis, Mann-Whitney and Pearson’s chi-squared test tests were used considering P < 0.05 for significance. Results The majority respondents had no training in palliative care (77.8%), however, 58.3% declared that they cared for at least 1 palliative care patient every 2 shifts - an intermediate frequency in our analysis. Trauma levels among doctors were classified as medium (24 ± 6), burnout as low (19 ± 5) and compassion as medium (41 ± 5). Professionals without training in palliative care had higher rates of burnout ( P = 0.002), but there was no association between training and rates of trauma or compassion. Conclusions Doctors with training in palliative care in Brazil showed lower burnout rates when working as general practitioners in secondary hospitals. This could instigate the implementation of educational programs in palliative care at hospitals and the further development of the field so as to improve professionals’ performance at patients’ treatment. There was no difference between Trauma and Compassion scores.
Identifying optimal candidates and interventions in physical therapy and exoskeletal and end-effector robot-assisted gait training for balance, gait, and cognition: A longitudinal study of 190 patients with stroke
Authors: Kim Yunhwan , Kim Heejun , Park Seonmi , Shin Jiwon , Park Haeun , Choi Jongeun , Kim Hansung , Park Myungsook , You Joshua Sung H. 
Published: December 2024

Background Optimal candidates and interventions for advanced robot-assisted stroke gait rehabilitation remain unknown. Objective We aimed to determine the optimal therapeutic efficacy for balance, sensorimotor and locomotor functions, daily activity, and cognition between the lower-entering functional ambulation category (L-FAC) and higher-entering FAC (H-FAC) groups. Methods 190 stroke patients received conventional physical therapy (CPT), exoskeletal robotic-assisted gait training (RAGT), or end-effector RAGT (eRAGT), each comprising 60-min/session, two times per week for 10–20 weeks. Standardized clinical tests included the Fugl–Meyer assessment of the lower extremities, Berg balance scale, FAC, modified Barthel index, and mini-mental state examination. A two-way analysis of variance was performed, with significance set at P < 0.05. Results Both groups demonstrated significant improvements. Compared with the H-FAC group, L-FAC group achieved the most notable improvements in sensorimotor function, balance, gait, daily activity, and cognition after RAGT, followed by CPT and eRAGT ( P < 0.05). Conclusions RAGT was more effective than CPT and eRAGT on sensorimotor function, balance, and gait function in patients with stroke with L-FAC. We identified the optimal candidates and interventions for balance, gait, and cognition patients with stroke.
Evaluation of cyclin-dependent kinase 4/6 inhibitor-induced serum creatinine elevations in patients with hormone receptor positive breast cancer
Authors: Ly Emily , Howard Frederick M , Chen Nan , Hahn Olwen , Fleming Gini F , Nanda Rita , Patel Shivani , Thimothy Lida , Yang Heng 
Published: December 2024

Background Cyclin-dependent kinase 4 and 6 inhibitors (CDK4/6i) have improved the efficacy of endocrine therapy in hormone receptor-positive (HR+)/human epidermal growth factor receptor 2-negative (HER2-) breast cancer (BC) and are now used in both early-stage and metastatic disease. Recent case reports suggest that pseudo-serum creatinine (Scr) elevations are likely a class effect of CDK4/6i. Methods This single-center retrospective analysis included patients aged ≥18 years who received at least one dose of palbociclib, ribociclib, or abemaciclib for the treatment of HR+/HER2- BC in the early or advanced setting. The primary objective was the incidence of pseudo-Scr elevation for each of the three agents. CDK4/6i-induced pseudo-Scr elevation was suspected when the Scr elevation could not be fully attributed to other causes. Secondary endpoints included the grade, onset, duration, and clinical consequences of pseudo-Scr elevation. Results 143 patients were included. Pseudo-Scr elevation was suspected in patients treated with palbociclib, ribociclib, or abemaciclib, with incidences of 16% (8/50), 14% (6/43), and 20% (10/50), respectively. Rates did not significantly differ between agents ( p = 0.727). Among patients with CDK4/6i-induced pseudo-Scr elevation, all events were grade 1 (8.3%) or 2 (91.7%). The median onset from treatment initiation to first Scr elevation was 33.5, 42, and 21.5 days, for palbociclib, ribociclib, or abemaciclib, respectively. Conclusion Pseudo-Scr elevation appears to be a class effect of CDK4/6i, with similar rates of Scr elevation observed across the three agents currently FDA approved.
Genetic testing: practical dos and don’ts for cats
Authors: Lyons Leslie A 
Published: December 2024

Practical relevance: A significant number of genetic variants are known for domestic cats and their breeds. Several DNA variants are causal for inherited diseases and most of the variants for phenotypic traits have been discovered. Genetic testing for these variants can support breeding decisions for both health and aesthetics. Genetic testing can also be used to monitor for the health of, or provide targeted therapy for, an individual cat and, more widely, can progress scientific discovery. Technological improvements have led to the development of large panel genetic testing, which can provide many DNA results for a low cost. Clinical challenges: With the development of large panel genetic testing has come companies that can carry out this service, but which company is best to use may not always be clear - more tests are not necessarily better. Usage and interpretation of genetic data and how the results are presented by commercial laboratories may also be confusing for veterinary practitioners and owners, leading to misinterpretations for healthcare, improper genetic counseling, and poor breed and population management. Evidence base: The information provided in this review draws on scientific articles reporting the discovery, and discussing the meaning and implications, of DNA variants, as well as information from the Online Mendelian Inheritance in Animals (OMIA) website, which documents all the DNA variant discoveries. The author also provides suggestions and recommendations based on her personal experience and expertise in feline genetics. Audience: This review is aimed at general practitioners and discusses the genetic tests that can be performed, what to consider when choosing a testing laboratory and provides genetic testing counseling advice. Practitioners with a high proportion of cat breeder clientele will especially benefit from this review and all veterinarians should realize that genetic testing and genomic medicine should be part of diagnostic plans and healthcare for their cat clients.
Predictive value of preoperative gluteus and iliacus muscle volumes for patient-reported outcomes following total hip replacement: a three-dimensional volumetric analysis
Authors: Ham Dae-Woong , Choi Gil Won , Yoo Yi Sack , Kim Chul-Ho 
Published: December 2024

Introduction: This study aimed to investigate the relationship between hip muscle mass and patient-reported outcomes (PROs) after total hip arthroplasty (THA) surgery for hip disease using 3D volumetric measurements of the gluteus muscle group and iliac muscle. Materials and Methods: Between January 2020 and December 2021, 85 patients who had undergone unilateral THA for osteoarthritis or osteonecrosis of the femoral head were enrolled. Using a 3D modeler program, automatically generated 3D reconstructed images of the hip muscles were obtained, and volumetric measurements were performed. Both unadjusted and height (m2)-adjusted muscle volumes of the gluteus maximus (unadjusted volume: GmaxV; adjusted volume: GmaxI), gluteus medius (unadjusted volume: GmedV; adjusted volume: GmedI), gluteus minimus (unadjusted volume: GminV; adjusted volume: GminI), and iliacus (unadjusted volume: IliacV; adjusted volume: IliacI) muscles were measured on the affected side and both sides. Pearson correlation analysis between muscle volumes and postoperative 12-month PROs were performed. Results: The preoperative Gmax volume on the affected side was significantly associated with post-operative PROs, especially mHHS (GmaxV: p = 0.026; GmaxI: p = 0.005) and UCLA scores (GmaxV: p = 0.006; GmaxI: p = 0.002). For measurements on both sides, Gmed volume was the sole index showing a significant correlation with postoperative UCLA scores (GmedV: p = 0.023; GmedI: p = 0.043). Conclusions: The current study suggests that preoperative gluteus muscle volume may have predictive value for postoperative PROs of hip disease patients who have undergone THA surgery.
Understanding the complex network of objectively assessed cognition and self-reported psychological symptoms in people with multiple sclerosis
Authors: van Dam Maureen , Röttgering Jantine G , Nauta Ilse M , de Jong Brigit A , Klein Martin , Schoonheim Menno M , Uitdehaag Bernard MJ , Hulst Hanneke E , Douw Linda 
Published: December 2024

Background: Literature on the intricate relationship between self-reported and objectively assessed cognitive functioning suggests a discrepancy between self-reported cognitive complaints (SCC) and actual test performance. Objectives: To investigate the interplay between patient-reported outcome measures (PROMs) and objective cognitive functioning using network analysis in people with multiple sclerosis (PwMS). Methods: We collected PROMs on anxiety, depression, fatigue and SCC, and cognitive functioning across six domains ( n = 703 PwMS; 71% female, mean age = 46.3 ± 11.2 years). We constructed cognitive symptom networks using Gaussian Graphical Models, in which the aforementioned variables were presented as nodes linked by regularized partial correlations. We compared global network strength between relevant subgroups. Results: The networks primarily showed clustering of PROMs and cognitive domains into two separate modules, with weaker links connecting both modules. Global network strength was lower for PwMS with impaired information processing speed (IPS; indicating lower symptom interrelatedness) compared to those with preserved IPS (3.57 versus 4.51, p = 0.001), but not when comparing SCC subgroups ( p = 0.140). Conclusions: Cognitive symptom networks deepen our understanding of the discrepancy between self-reported and objectively assessed cognitive functioning. Lower symptom interrelatedness in PwMS with impaired IPS might suggest a nonlinear relation between PROMs and cognitive domains, which depends on the cognitive status.