bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparative study on nutritional composition of fish available in Portugal
Authors: Marques Ivone , Botelho Goreti , Guiné Raquel 
Published: April 2019

Purpose
The Mediterranean diet is one of the healthiest eating patterns and relies much on the regular consumption of fish, which is a source of unsaturated fatty acids, protein, vitamins and minerals. The purpose of this study was to describe and compare the macronutrients and micronutrients profile of 24 commercial fish species available in the Portuguese market.

Design/methodology/approach
A comparative study was undertaken based on nutritional datasheets provided by laboratories and based on the database of the Portuguese National Health Institute Doutor Ricardo Jorge.

Findings
The results obtained showed that while most of the fish species are low-fat, gilthead and salmon are considered high in fat, with salmon presenting significant amounts of unsaturated fatty acids. The blue shark shows the highest amounts of protein, whereas codfish shows significantly high levels of salt content. Sardine is much richer in terms of vitamins than the other species. With respect to minerals, there is a lot of variation among species. It is worth noticing the skate, with high amounts of sodium, calcium and phosphorous. Statistical analysis evidenced some relations between the properties evaluated, and it was possible to establish two distinct groups of fish through cluster analysis.

Practical implications
The species evaluated revealed a highly important nutritional value that should be an incentive to their regular consumption. Moreover, a lack of nutritional information about some micronutrients was found in several fish species, which should be studied in future studies.

Originality/value
This paper fulfils an identified need to compare nutritional composition of fish available in Portugal.
Drivers of customer satisfaction and loyalty in swimming pools
Authors: Moura e Sá Patrícia , Cunha Patrícia 
Published: April 2019

Purpose
It is widely accepted that doing exercise regularly is essential to promote physical, psychological and social well-being. Yet, often dropout rates tend to be high. The purpose of this paper is to propose a model to understand the potential drivers of satisfaction and loyalty in the sports and fitness context looking in particular at four main dimensions of service quality: infrastructures/physical environment, relationship with instructors/staff, outcomes achieved and customer-to-customer interaction.

Design/methodology/approach
An extensive literature review was conducted to identify potential drivers of customer satisfaction and loyalty in sports. The proposed model was estimated using data collected from a sample of 384 users of four Portuguese swimming pools facilities by means of a survey questionnaire.

Findings
The majority of the hypotheses tested found support in the data. In particular, the quality of the interaction with instructors and the results obtained from exercising have a strong impact on satisfaction, which, in turn, is highly correlated with psychological commitment and positive word-of-mouth communication.

Research limitations/implications
Based on the findings some managerial implications can be derived. Such recommendations can enhance users’ perceptions of service quality and indirectly contribute to a more regular and effective sports practice.

Originality/value
The importance of enhancing loyalty has been emphasised in sports management literature. Yet, few studies have empirically investigated the simultaneous relationships among service quality dimensions, customer satisfaction and loyalty. This research partially addresses this gap.
Molecular and functional characterization of three odorant‐binding proteins from the wheat blossom midge, Sitodiplosis mosellana
Authors: Cheng Wei‐Ning , Zhang Yu‐Dong , Liu Wei , Li Guang‐Wei , Zhu‐Salzman Keyan 
Published: April 2019

AbstractSitodiplosis mosellana, a periodic but devastating wheat pest, relies on wheat spike volatiles as a cue in selecting hosts for oviposition. Insect odorant‐binding proteins (OBPs) are thought to play essential roles in filtering, binding and transporting hydrophobic odorant molecules to specific receptors. To date, the molecular mechanisms underlying S. mosellana olfaction are poorly understood. Here, three S. mosellana antenna‐specific OBP genes, SmosOBP11, 16 and 21, were cloned and bacterially expressed. Binding properties of the recombinant proteins to 28 volatiles emitted from wheat spikes were investigated using fluorescence competitive binding assays. Sequence analysis suggested that these SmosOBPs belong to the Classic OBP subfamily. Ligand‐binding analysis showed that all three SmosOBPs preferentially bound alcohol, ester and ketone compounds, and SmosOBP11 and 16 also selectively bound terpenoid compounds. In particular, the three SmosOBPs had high binding affinities (Ki < 20 μmol/L) to 3‐hexanol and cis‐3‐hexenylacetate that elicited strong electroantennogram (EAG) response from female antennae. In addition, SmosOBP11 displayed significantly higher binding (Ki < 8 μmol/L) than SmosOBP16 and 21 to 1‐octen‐3‐ol, D‐panthenol, α‐pinene and heptyl acetate which elicited significant EAG response, suggesting that SmosOBP11 plays a major role in recognition and transportation of these volatiles. These findings have provided important insight into the molecular mechanism by which S. mosellana specifically recognizes plant volatiles for host selection, and have facilitated identification of effective volatile attractants that are potentially useful for pest monitoring and trapping.
Investigation of the effect of P14 promoter aberrant methylation on the biological function of human lung cancer cells
Authors: Jia Bing‐Yang , Yang Rong‐Hua , Jiao Wen‐Jie , Tian Kai‐Hua 
Published: April 2019

BackgroundThis study was conducted to investigate the effect of P14 promoter aberrant methylation on the biological function of human lung adenocarcinoma cells.MethodsWe used nested methylation‐specific PCR (NMSP) to detect the methylation status of the p14ARF promoter region in SPCA1 and BEAS2B cell lines. The experimental groups were treated with 5‐aza‐2′‐deoxycytidine (5‐Aza). Quantitative real‐time PCR, Western blot, flow cytometry, and Cell Counting Kit 8 were used to detect the expression of p14ARF messenger RNA and protein in each group, apoptosis, and cell proliferation inhibition, respectively.ResultsNMSP detected that the p14 promoter region of SPCA1 cells has abnormal methylation status. After treatment with 5‐Aza, the expression of p14ARF messenger RNA and protein in SPCA1 cells (P < 0.05) and the inhibition rate of cell proliferation (P < 0.05) were significantly increased, while the apoptosis rate was markedly increased (P < 0.05). However, no differences were observed in BEAS2B cells (P > 0.05).ConclusionAbnormal methylation of the p14ARF promoter region plays an important role in the development of lung cancer cells. Our results suggest the use of P14 promoter aberrant methylation as a therapeutic target for drug research or to improve the sensitivity of other drugs.
Editorial: effects of vildagliptin on GLP‐1 levels, gastric motor function and food intake
Authors: Camilleri Michael 
Published: April 2019

Linked ContentThis article is linked to Rotondo et al and Masuy papers. To view these articles, visit https://doi.org/10.1111/apt.15195 and https://doi.org/10.1111/apt.15242.
Letter: dietary fibre benefits for the oesophagus—physical rather than metabolic action? Authors’ reply
Authors: O’Grady John , Shanahan Fergus 
Published: April 2019

Linked ContentThis article is linked to O’Grady et al and Morozov papers. To view these articles, visit https://doi.org/10.1111/apt.15129 and https://doi.org/10.1111/apt.15233.
Editorial: population‐based testing for Helicobacter pylori in Western countries. Authors' reply
Authors: Høgh Maria Bomme , Kronborg Christian , Møller Hansen Jane , Wildner‐Christensen Mette , Schaffalitzky de Muckadell Ove B. 
Published: April 2019

Linked ContentThis article is linked to Høgh et al and Vakil papers. To view these articles, visit https://doi.org/10.1111/apt.15193 and https://doi.org/10.1111/apt.15224.
Moral dilemmas in (not) treating patients who feel they are a burden
Authors: Metselaar Suzanne , Widdershoven Guy 
Published: April 2019

AbstractWorking as clinical ethicists in an academic hospital, we find that practitioners tend to take a principle‐based approach to moral dilemmas when it comes to (not) treating patients who feel like a burden, in which respect for autonomy tends to trump other principles. We argue that this approach insufficiently deals with the moral doubts of professionals with regard to feeling that you are a burden as a motive to decline or withdraw from treatment. Neither does it take into adequately account the specific needs of the patient that might underlie their feeling of being a burden to others. We propose a care ethics approach as an alternative. It focuses on being attentive and responsive to the caring needs of those involved in the care process—which can be much more specific than either receiving or withdrawing from treatment. This approach considers these needs in the context of the patient's identity, biography and relationships, and regards autonomy as relational rather than as individual. We illustrate the difference between these two approaches by means of the case of Mrs K. Furthermore, we show that a care ethics approach is in line with interventions that are found to alleviate feeling a burden and maintain that facilitating moral case deliberation among practitioners can supports them in taking a care ethics approach to moral dilemmas in (not) treating patients who feel like a burden.
Pharmacological modulation of the spatiotemporal disposition of micromotions in the intact resting urinary bladder of the rabbit; their pattern is under both myogenic and autonomic control
Authors: Hulls Corrin Murray , Lentle Roger Graham , King Quinten Michael , Chambers John Paul , Reynolds Gordon Willougby 
Published: April 2019

ObjectivesTo explore and characterize the disposition and dynamics of micromotions in the wall of the intact resting teradotoxinized urinary bladder of the rabbit before and after the administration of adrenergic and cholinergic pharmaceutical agents.MethodsSpatiotemporal maps and related intravesical pressure were used to analyse propagating patches of contractions (PPCs) and their component individual myogenic contractions [propagating individual contractions (PICs)] in the wall of the tetradotoxinized urinary bladder.ResultsThe bladder wall exhibited two contractile states that were of similar frequencies to those of the two types of electrophysiological discharge described in previous studies; the first, in which cyclic PPCs predominated, the second in which small irregular PICs predominated. The addition of carbachol increased the size, frequency, speed and distance of propagation of PPCs, whereas the addition of isoprenaline temporarily halted the incorporation of PICs into PPCs, and reduced patch size and total area undergoing contraction. The RhoA kinase (ROCK) inhibitor Y‐27632 reduced both largest patch index and mean patch size. Both carbenoxolone and ROCK inhibition decreased the duration of PPCs. Carbenoxolone also prolonged duration and accelerated PPC propagation velocity. The authors postulate that these differences arise from differing effects of these agents on myocytes and interstitial cells within the stress environment of the bladder, influencing the development, coordination and propagation of PPCs.ConclusionsThe timings and structure of spontaneous micromotions in the wall of the isolated bladder change when it is treated with sympathetic/parasympathetic agonists and with myogenically active agents. Correspondingly, disorders of bladder wall contraction may result from disorders of either neurogenic or myogenic signalling and may be amenable to treatment with combinations of agents that influence both.
Obstruction is associated with perineural invasion in T3/T4 colon cancer
Authors: Nozawa H. , Morikawa T. , Kawai K. , Hata K. , Tanaka T. , Nishikawa T. , Sasaki K. , Shuno Y. , Kaneko M. , Hiyoshi M. , Emoto S. , Murono K. , Sonoda H. , Fukayama M. , Ishihara S. 
Published: April 2019

AbstractAimPerineural invasion (PNI) is a risk factor for recurrence and metastasis and consequently leads to decreased survival in patients with various malignancies. Recent studies showed that stent placement in obstructive colon cancer increases the frequency of PNI. We hypothesized that mechanical stress including obstruction itself may be associated with PNI.MethodWe retrospectively reviewed 496 patients with pathological T3 or T4 colon cancer who did not receive preoperative treatment. Data were collected from medical charts and pathological findings. The relationships between PNI and other clinicopathological factors were analysed using univariate and multivariate analyses.ResultsPNI was observed in 239 (48%) patients. Obstruction was markedly more frequent in PNI‐positive cancer (39%) than in PNI‐negative cancer (24%, P = 0.0003). Multivariate analyses identified obstruction as one of the significant factors associated with PNI (OR 1.68, P = 0.028). Moreover, in 414 patients without distant metastasis who underwent complete resection, PNI was an independent factor associated with poor recurrence‐free survival (hazard ratio 2.35, P = 0.003). The coexistence of PNI and obstruction resulted in greater decreases in recurrence‐free survival than PNI‐negative and/or non‐obstructive cases.ConclusionOur results suggest that obstruction is associated with PNI and consequently contributes to an increased postoperative recurrence in colon cancer.
Relationships among social support, empathy, resilience and work engagement in haemodialysis nurses
Authors: Cao X. , Chen L. 
Published: April 2019

AimTo describe the levels of work engagement, and to analyse the reciprocal relationships between social support, empathy, resilience and work engagement among haemodialysis nurses in China.BackgroundWork engagement is a critical workplace health indicator. Previous studies have examined work engagement perceived by nurses working in diverse hospital wards, or a specialty area (emergency care or intensive care), no previous studies have highlighted work engagement and its affecting factors among haemodialysis nurses.MethodsParticipants in the cross‐sectional study were 345 haemodialysis nurses employed in 17 hospitals in Chengdu, China. Hierarchical regression analyses were carried out to analyse the relationships between social support, empathy, resilience and work engagement in haemodialysis nurses.ResultsResilience was the strongest positive significant contributor to work engagement, followed by other support and perspective taking (cognitive empathy). Nurses with longer occupational tenure reported higher levels of work engagement. Male nurses also reported greater work engagement than female nurses.DiscussionInfluence of work engagement was explored by social support, empathy and resilience, reflecting the need of haemodialysis nurses to understand the significance of focusing on their personal and environmental factors.ConclusionsPositive resilience, other support and cognitive empathy can result in increased work engagement.Implications for nursingTraining programs, such as mindfulness meditation training and empathy skills training, are recommended for nursing managers to enhance resilience and empathic capacity in nurses.Implications for nursing policyNursing policies should be developed to establish supportive work environments in clinical practice settings and to support the education and training of psychological resilience and empathic capacity in order to foster work engagement.
Remission induction, maintenance, and endoscopic outcome with oral 5‐aminosalicylic acid in intestinal Behçet's disease
Authors: Kinoshita Hiroto , Nishioka Hitomi , Ikeda Aya , Ikoma Kyoko , Sameshima Yoichi , Ohi Hidehisa , Tatsuno Mizuki , Kouyama Junka , Kawamoto Chiaki , Mitsui Tomohiro , Tamura Yuko , Hashimoto Yu , Nishio Masashi , Ogashiwa Tsuyoshi , Saigusa Yusuke , Maeda Shin , Kimura Hideaki , Kunisaki Reiko , Koike Kazuhiko 
Published: April 2019

AbstractBackground and AimOral 5‐aminosalicylic acid (5‐ASA) is recommended for the therapy of mild to moderate intestinal Behçet's disease (BD). However, the induction remission efficacy and endoscopic outcomes of 5‐ASA are unknown. We investigated remission induction at 8 weeks, endoscopic outcomes until 52 weeks, and event‐free survival at 52 weeks in patients with intestinal BD treated with 5‐ASA.MethodsForty‐one patients with intestinal BD were treated with oral 5‐ASA. Clinical remission was evaluated with the Crohn's disease activity index (CDAI). The endoscopic response was evaluated using the modified global gastrointestinal endoscopic assessment scores. Rescue therapy‐free survival and surgery‐free survival at 52 weeks were estimated, and predictive factors for a clinical response at weeks 8 and 52 were identified.ResultsSeven patients (17%) withdrew 5‐ASA early (≤ 8 weeks) because of adverse events. At week 8, clinical efficacy could be accurately evaluated in 28 patients, and the response and remission rates were 61% and 57%, respectively, using the CDAI. Endoscopic evaluation was achieved in 17 patients up to 52 weeks, and the endoscopic response and remission rates were 71% and 35%, respectively. The probabilities of rescue therapy‐free survival and surgery‐free survival were 73% and 100%, respectively, at 52 weeks in all 41 patients. The predictive factors for therapeutic effectiveness at week 8 were a higher baseline C‐reactive protein level and CDAI, but they were negative predictive factors for a 52‐week response.Conclusions5‐ASA is effective for clinical and endoscopic induction and maintaining a response in patients with mild to moderate intestinal BD.
The Montreal Cognitive Assessment After Omission of Hearing‐Dependent Subtests: Psychometrics and Clinical Recommendations
Authors: Al‐Yawer Faisal , Pichora‐Fuller M. Kathleen , Phillips Natalie A. 
Published: April 2019

ObjectivesHearing loss (HL) is the third most common chronic health condition in older adults, yet it is often undiagnosed and/or untreated. Given the association between HL and cognitive impairment, it is expected that many people undergoing cognitive screening may have HL. The Montreal Cognitive Assessment (MoCA) is a brief screening test that assesses a wide range of cognitive functions sensitive to Alzheimer's disease (AD) and mild cognitive impairment (MCI). Although MoCA items were carefully designed to be sensitive to deficits in MCI, they were not designed to take sensory declines into account. In the current investigation, we examined the MoCA's psychometric properties following omission of subtests primarily dependent on hearing status (memory, digit span, attention to letters, and sentence repetition).DesignCross‐sectional analytic design (retrospective analysis).SettingWe used the original MoCA validation study data.4ParticipantsGroups consisted of healthy controls (N = 90), subjects with MCI (N = 94), and subjects with mild AD (N = 93).MeasurementsWe assessed sensitivity and specificity using absolute and proportional cutoff score adjustments. We developed receiver operating characteristics curves to determine the best cutoff values for both MCI and AD patients using different combinations of auditory subtest omissions.ResultsCompared with the original MoCA (MCI sensitivity = 90%; specificity = 87%), MCI sensitivity was substantially reduced (absolute scoring = 43%; proportional scoring = 56%) when all auditory subtests were omitted, with the biggest contribution to the reduction coming from the delayed recall subtest. Excluding three subtests and maintaining the delayed recall had no effect on MCI sensitivity but reduced specificity (sensitivity = 94%, specificity: 71% using proportional scoring). AD sensitivity, in contrast, was not strongly influenced by our manipulation and remained relatively high through all three subtest omission combinations.ConclusionThe current study highlights the contribution of hearing‐dependent subtests on the sensitivity and specificity of the MoCA. Clinical recommendations related to these findings are discussed. J Am Geriatr Soc 67:1689–1694, 2019
No time to delay reperfusion: A cross‐sectional study of primary percutaneous coronary intervention times
Authors: Roe Amanda , Banka Prakashini , Mooney Mary 
Published: April 2019

AbstractAims and objectivesTo establish and report cross‐sectional data of reperfusion times for emergency primary percutaneous coronary interventions (PPCI) and to examine factors associated with times to reperfusion.BackgroundRapid coronary reperfusion can salvage myocardial tissue, preserve left ventricular function and reduce mortality. PPCI is the gold standard of management. Researchers have reported on international median reperfusion times, but this is the first Irish study to do so.MethodsThis observational, prospective, cross‐sectional study included patients diagnosed with ST‐segment elevation myocardial infarction (STEMI) and admitted for emergency PPCI. Descriptive and inferential statistics were used. The study was ethically approved. We adopted the STROBE guidelines.ResultsAll patients (N = 133) who met the inclusion criteria were included initially. Of these, 105 (79%) were diagnosed with STEMI and received emergency PPCI. The majority of STEMIs were diagnosed by paramedics and most (67%) were reperfused within 120 min, with a median time of 96 min. The results suggested that younger patients achieved timelier PPCI and source of referral was also significant in that more of those transferred directly to the coronary catheterisation laboratory achieved reperfusion within 120 min, compared with those who presented to the emergency department.ConclusionA timely reperfusion service is achieved for the majority. Attention is needed in respect of the ageing and those admitted directly to the emergency departments with STEMI.Relevance to clinical practiceFurther international research is recommended to compare current reperfusion times against guidelines and to identify areas for improvement. Clinicians should be mindful of the importance of rapid reperfusion and the implications of its delay for patients with STEMI. Those presenting to emergency departments with chest pain should be prioritised.