bluuebunny/crossref_metadata_2025_split huggingface dataset:
Polarization, Participation, and Premiums: How Political Behavior Helps Explain Where the ACA Works, and Where It Doesn't
Authors: Trachtman Samuel 
Published: August 2019

Abstract
Context: Political partisanship can influence whether individuals enroll in government programs. In particular, Republicans, ceteris paribus, are less likely to enroll in Affordable Care Act (ACA) individual marketplace insurance than Democrats. The logic of adverse selection suggests low uptake among Republicans would generally put upward pressure on marketplace premiums, especially in geographic areas with more Republican partisans.
Methods: Using data from Healthcare.gov at the rating area level, this article examines the association between Republican vote share and growth in ACA marketplace premiums, being careful to account for potential confounding variables.
Findings: Insurers have increased marketplace premiums at higher rates in areas with more Republican voters. In the preferred model specification, a 10-percentage-point difference in Republican vote share is associated with a 3.2-percentage-point increase in average premium growth for a standard plan. A variety of robustness and placebo checks suggest the relationship is driven by partisanship.
Conclusions: Partisan polarization can threaten the successful implementation of policies that rely on high levels of citizen participation.
Affordable Care Act Moving to New Stage of Public Acceptance
Authors: Jacobs Lawrence R. , Mettler Suzanne , Zhu Ling 
Published: August 2019

Abstract
The Affordable Care Act (ACA) was enacted in a deeply polarized context, and it has endured multiple challenges to its implementation and its very existence that continue to this day. Yet, we find that the law is entering a new phase of acceptance among the American public, such that it presents political risks to politicians who would dare to weaken it. We have conducted a panel study of Americans' public opinion on the ACA since 2010, returning to the same respondents every two years to ask the same questions. This approach, which is essential for tracking change, reveals that support for the ACA is growing and the most intense opposition is receding. It also shows that Americans' sense of the law's impact on their lives is at least holding steady and in some respects growing. Most strikingly, those who feel favorably toward the law are more engaged politically than those who oppose it, and they are more likely to take it into account when they vote. These trends indicate that the law, despite the legal and political obstacles it still confronts, is becoming more firmly established in public opinion and through patterns of political participation.
Performing Piety in Pakistan's Transgender Rights Movement
Authors: Pamment Claire 
Published: August 2019

AbstractPakistani hijra/khwaja siras make up structured communities of feminine-identified gender-variant persons who have long but marginalized traditions of performing religious-cultural roles. Supreme Court rulings in 2009, promising rights to marginalized khwaja siras, have led to increased backlash against these performances and the community structures on which they rest. This article explores these traditional performance practices, within the Sufi shrine and in homes, as well as in explicit activism as khwaja siras contested their place in the national 2013 elections. These assertions of piety, drawn creatively from Sufi and Shi'a modes and often performed on the fringes or lower rungs of developmental activism, offer an embodied outlet for negotiating multiple axes of exclusion. While recent scholarship has claimed that in the context of reformist Islamic movements khwaja siras are turning away from the spaces of legitimacy that Sufism once offered and toward the liberal language of human rights to make claims for recognition, the author argues that these pious performances continue to provide a potent force for transgender activism in Pakistan.
The MuslimWariaof Yogyakarta
Authors: Rodriguez Diego Garcia 
Published: August 2019

AbstractBased on fieldwork conducted with Muslim waria (a term roughly translated as transgender women) in the city of Yogyakarta, Indonesia, this article analyzes the gendered, sexual, and religious lived realities of these individuals. Drawing on research comprising ten in-depth, semistructured interviews, and observations at the pesantren waria (Islamic boarding school for Muslim waria), this article investigates the ways in which the participants construct their “wariahood” in relation to the assumed presence of a jiwa perempuan (female soul/spirit), challenging the common conflation of agency with resistance. The empirical discussion first explores the emergence of the waria subject position through the existence of their female jiwa, while the second part addresses the importance of Islam as a source of potential agentic power for these individuals.
The expanding spectrum of neurological disorders of phosphoinositide metabolism
Authors: Volpatti Jonathan R. , Al-Maawali Almundher , Smith Lindsay , Al-Hashim Aqeela , Brill Julie A. , Dowling James J. 
Published: August 2019

ABSTRACT
Phosphoinositides (PIPs) are a ubiquitous group of seven low-abundance phospholipids that play a crucial role in defining localized membrane properties and that regulate myriad cellular processes, including cytoskeletal remodeling, cell signaling cascades, ion channel activity and membrane traffic. PIP homeostasis is tightly regulated by numerous inositol kinases and phosphatases, which phosphorylate and dephosphorylate distinct PIP species. The importance of these phospholipids, and of the enzymes that regulate them, is increasingly being recognized, with the identification of human neurological disorders that are caused by mutations in PIP-modulating enzymes. Genetic disorders of PIP metabolism include forms of epilepsy, neurodegenerative disease, brain malformation syndromes, peripheral neuropathy and congenital myopathy. In this Review, we provide an overview of PIP function and regulation, delineate the disorders associated with mutations in genes that modulate or utilize PIPs, and discuss what is understood about gene function and disease pathogenesis as established through animal models of these diseases.
A opinião pública da sociedade mercosulina e os caminhos do bloco nos anos 2010
Authors: Silva Geraldello Camilla 
Published: August 2019

O objetivo desse trabalho é verificar qual o modelo de inserção internacional do Mercosul apoiado pelos cidadãos dos países do bloco na década de 2010. O Mercosul passou por mudanças de ênfase em decorrência do cenário internacional e das políticas externas dos membros. Se durante os anos 1990, o bloco e os membros foram guiados pelo neoliberalismo e por relações com parceiros tradicionais, a partir dos anos 2000, as políticas sociais ganharam destaque e os membros apostaram na diversificação de parceiros comerciais. Todavia, a partir de 2015 o Mercosul entrou em novo momento de mudança com o redirecionamento político, à centro-direita, de alguns países sul-americanos. Dessa forma, procuramos mostrar por meio dos dados do Latinobarómetro de 2010 a 2016 para qual direção a sociedade mercosulinadeseja se mover: se para fortalecimento das relações Sul-Sul ou das relações Norte-Sul; se para o incremento de relações via comércio ou via políticas sociais.
Colocación y relaciones de trabajo. Niños, niñas y jóvenes en el centro y sur de la Provincia de Buenos Aires
Authors: De Paz Trueba Yolanda 
Published: August 2019

En los años finales del siglo XIX y los comienzos del XX, se vigorizó la colocación de niños, niñas y jóvenes con familias diferentes a las de origen. El objetivo del presente trabajo es repensar el vínculo entre criados y depositarios en la provincia de Buenos Aires. El artículo indaga sobre el origen de las colocaciones y los variados arreglos laborales que conllevaban. Se asume que eran parte de una relación paternalista que combinaba deberes y obligaciones, unidos por un vínculo laboral. Esta tarea se hará a través de los fondos documentales de las Defensorías de Menores y Juzgados de Paz de la zona estudiada.
Nombrar lo innombrable. La querella en torno al concepto de religión política para definir los totalitarismos
Authors: Souroujon Gastón 
Published: August 2019

El presente trabajo se propone presentar un episodio en el devenir histórico del concepto de Religión Política como herramienta interpretativa de los totalitarismos, el período en el cuál el concepto comienza a ser cuestionado por parte de intelectuales reconocidos. Debate en torno a la legitimidad del concepto que pensamos debe ser comprendido como un capítulo de dos de las querellas fundamentales de la modernidad: la querella en torno al significado de la secularización y en torno al status de la ciencia política. Capítulo que ha sido ignorado por los historiadores que han generado el presente renacer del concepto. A través de estos lentes se analizaran los argumentos principales de los pensadores que han participadode este debate: Aron, Arendt, Kelsen y Voegelin.
Efficient Hyperparameter Tuning with Grid Search for Text Categorization using kNN Approach with BM25 Similarity
Authors: Ghawi Raji , Pfeffer Jürgen 
Published: August 2019

Abstract
In machine learning, hyperparameter tuning is the problem of choosing a set of optimal hyperparameters for a learning algorithm. Several approaches have been widely adopted for hyperparameter tuning, which is typically a time consuming process. We propose an efficient technique to speed up the process of hyperparameter tuning with Grid Search. We applied this technique on text categorization using kNN algorithm with BM25 similarity, where three hyperparameters need to be tuned. Our experiments show that our proposed technique is at least an order of magnitude faster than conventional tuning.
Inter-Organizational Design Thinking in Education: Joint Work between Learning Sciences Courses and a Zoo Education Program
Authors: Zuiker Steven J. , Jordan Michelle 
Published: August 2019

AbstractA case study of design thinking in education considers how two educational organizations—a university graduate program and a public zoo—develop and enact design thinking processes in relation to one another. It also examines how this inter-organizational design thinking project contributes to a “center without walls,” or collaboratory (Wulf, 1993), pursuing an aspirational vision: to support interest-driven learning while also connecting youth to a wider landscape of formal and informal learning opportunities among educational organizations in a major US metropolitan area. As an initial step in pursuit of this vision, the work of the collaboratory concentrated on one of the zoo’s community-focused education programs called Overnight Adventure. Over seventeen weeks, the project involved the collaborative efforts of two faculty and twelve students from a college of education, and three full-time staff and nineteen part-time instructors from a zoo education program across ten inter-organizational events and observations of five Overnight Adventures. To characterizer inter-organizational design, the case employs contiguity-based connecting strategies to analyze design thinking across four timescales. Findings describe the structures and processes of inter-organizational design thinking and the role of cultivating relational agency.
Soziale Bewegungen im Zusammenspiel mit politischen Parteien: Eine aktuelle Bestandsaufnahme
Authors: Hutter Swen , Kriesi Hanspeter , Lorenzini Jasmine 
Published: August 2019

Zusammenfassung
In diesem Beitrag skizzieren wir eine Forschungsagenda, die der Frage nachgeht wie sich die Interaktionen zwischen Bewegungen und Parteien sowohl quantitativ als auch qualitativ unter Bedingungen funktionierender repräsentativer Verbindungen einerseits und einer Repräsentationskrise andererseits unterscheiden. Die zentrale These lautet, dass unter Bedingungen von instabilen Repräsentationsmustern und von Bürger*innen, die sich nicht ausreichend politisch vertreten fühlen, diese Interaktionen deutlich häufiger, enger, aber auch konflikt- und folgenreicher werden. Dabei werden auch klare Zuordnungen von Parteien zum Institutionengefüge und von sozialen Bewegungen zum weniger institutionalisierten Bereich peripherer Herausforderer infrage gestellt.
Institutionalisierung als soziale Bewegung. Zum Verhältnis von sozialen Bewegungen und Institutionen jenseits des politischen
outcome
Authors: Pfister Jannik 
Published: August 2019

Zusammenfassung
Das Verhältnis von Bewegungen und Institutionen wurde lange vor allem als politischer outcome gefasst und nicht in Bezug auf langfristigen sozialen Wandel. Mit dem Blick auf kulturelle Folgen von Bewegungen schlägt dieser Beitrag vor, das Verhältnis als Institutionalisierung zu fassen, und so zur Annäherung von Bewegungsforschung und Gesellschaftstheorie beizutragen. Denn was in der Outcome-Forschung meist als Institutionen beschrieben wird, sind eher Organisationen der Regierung. Um besser fassen zu können, wie Bewegungen ebenso mit sozialen Institutionen interagieren wie mit in diese eingebetteten Organisationen, und so zu sozialem Wandel beitragen, wird eine auf Gramscis Hegemonietheorie, neuerer materialistischer Staatstheorie und verwandten Positionen aufbauende Perspektive vorgeschlagen.
Same same but different - Relationen zwischen Frauenbewegungen und politischen Institutionen im globalen Süden
Authors: Daniel Antje 
Published: August 2019

ZusammenfassungAnhand der Fallstudien zu Brasilien und Kenia arbeitet der Beitrag Unterschiede und Gemeinsamkeiten in der Relation zwischen politischen Institutionen und Frauenbewegung heraus und beschreibt damit kontextspezifische Besonderheiten und kontextübergreifende Tendenzen im globalen Süden. Im Fokus stehen die spezifischen Geschlechterpolitiken und die institutionellen Interaktionsräume sowie die Allianzen für die Interaktion mit politischen Institutionen. Die Analyse zeigt, dass Frauenbewegungen in einem vergleichbaren politischen Kontext agieren, denn beide Länder werden durch eine Überlappung der gesellschaftlichen und politischen Sphäre geprägt. Ebenso greifen Frauenbewegungen in beiden Ländern auf intermediäre Protestformen zurück und sind von ähnlichen geschlechtsspezifischen Machtmechanismen im Zugang zum politischen System geprägt. Jenseits der Gemeinsamkeiten kristallisieren sich kontextspezifische Aspekte heraus und somit Unterschiede, welche Brasilien als „partizipative Demokratie“ charakterisieren und Kenia als „politische Gesellschaft“.
Reversing Cocaine-Induced Plasticity with Zeta Inhibitory Peptide
Authors: Deutschmann Andre U. , Lenz Jeffrey D. , McGrath Anna G. , Briand Lisa A. 
Published: August 2019

Cocaine-induced plasticity persists during abstinence and is thought to underlie cue-evoked craving. Reversing this plasticity could provide an opportunity for therapeutic intervention. Converging evidence suggest that zeta inhibitory peptide (ZIP) eliminates memories for experience-dependent behaviors, including conditioned drug associations. However, the effect of ZIP on reward seeking and drug-induced plasticity is unknown. The current study examined the effect of ZIP administration in the nucleus accumbens on reinstatement (RI) of cocaine seeking, a rodent model of relapse. We demonstrate that intra-accumbal ZIP administration blocks cocaine-primed RI in rats when administered 24 h or 1 week before testing. These effects of ZIP on drug seeking are specific, as we did not see any effect of ZIP on RI of sucrose seeking. ZIP is a synthetic compound designed to inhibit the atypical PKC, PKMζ, a protein implicated in learning and memory. However, recent evidence from PKMζ-knock-out (KO) mice suggests that ZIP may function through alternative mechanisms. In support of this, we found that ZIP was able to block cue-induced RI in PKMζ-KO mice. One possible mechanism underlying addictive phenotypes is the ability of cocaine to block further plasticity. We hypothesized that ZIP may be working to reverse this anaplasticity. Although ZIP has no effect on accumbal LTD in slices from naive or yoked saline mice, it is able to restore both NMDA-dependent and mGluR5-dependent LTD in animals after cocaine self-administration and withdrawal. These findings demonstrate that intra-accumbal ZIP persistently reverses cocaine-induced behavioral and synaptic plasticity in male and female rodents.SIGNIFICANCE STATEMENTZeta-inhibitory peptide (ZIP) has been shown to disrupt memory maintenance for experience-dependent behaviors. We examined the effect of ZIP infused into the nucleus accumbens on the reinstatement (RI) of cocaine seeking. We found that intra-accumbal ZIP blocked RI of cocaine seeking 24 h and 1 week later. This effect was specific to RI of cocaine seeking as ZIP did not disrupt RI of food seeking. In conjunction with these behavioral studies we examined the ability of ZIP to reverse cocaine-induced deficits in LTD. We found that ZIP was able to rescue two forms of LTD in cocaine-experienced mice. These studies demonstrate that ZIP is able to reverse cocaine-induced behavioral and synaptic plasticity in a persistent manner.
Vitamin D affects insulin sensitivity and β-cell function in obese non-diabetic youths
Authors: Corica Domenico , Zusi Chiara , Olivieri Francesca , Marigliano Marco , Piona Claudia , Fornari Elena , Morandi Anita , Corradi Massimiliano , Miraglia del Giudice Emanuele , Gatti Davide , Rossini Maurizio , Bonadonna Riccardo C , Maffeis Claudio 
Published: August 2019

Objective
Vitamin D may potentially play a central role in glucose homeostasis and β-cell function (BCF), although studies are not consistent. Aim of our study was to test the hypotheses of a direct relationship between vitamin D, insulin sensitivity (IS) and BCF in overweight and obese non-diabetic children.

Design and methods
Cross-sectional study carried out at the Childhood Obesity Outpatient Clinic, University Hospital of Verona. One hundred twenty-two Caucasian overweight and obese children (age: 12.8 ± 0.2 years) were enrolled. Exclusion criteria: genetic or endocrine causes of obesity, chronic diseases or therapies. Patients underwent oral glucose tolerance test. HOMA-IR, Matsuda index and insulinogenic index were calculated. BCF was reconstructed by mathematical modeling and described by Derivative and Proportional Control. Total 25-hydroxyvitamin D and vitamin D-binding protein (VDBP) were measured. Two SNPs (rs4588 and rs7041) in the VDBP gene were studied, and bioavailable vitamin D (BVD) was calculated.

Results
Hypovitaminosis D was documented in 90% of patients. Forty-seven subjects were homozygous for both SNPs. Total vitamin D was positively correlated with Matsuda index (P = 0.002), VDBP (P = 0.045), and negatively with BMI SDS (P = 0.043), HOMA-IR (P = 0.008), HOMA-B (P = 0.001), IGI (P = 0.007), derivative control (P = 0.036) and proportional control (P = 0.018). Total vitamin D, adjusted for age, gender, BMI SDS, puberty and seasonality of vitamin D measurement, was a predictor of Matsuda index, HOMA-IR, HOMA-B, IGI, proportional control (all P < 0.05). BVD was positively correlated with total vitamin D (P < 0.001) and negatively with BMI SDS (P = 0.041).

Conclusions
Hypovitaminosis D negatively influences BCF and IS, suggesting that vitamin D levels might be implicated in glucose metabolism impairment in overweight and obese individuals.
RNA–DNA Hybrids Support Recombination-Based Telomere Maintenance in Fission Yeast
Authors: Hu Yan , Bennett Henrietta W , Liu Na , Moravec Martin , Williams Jessica F , Azzalin Claus M , King Megan C 
Published: August 2019

Abstract
A subset of cancers rely on telomerase-independent mechanisms to maintain their chromosome ends. The predominant “alternative lengthening of telomeres” pathway appears dependent on homology-directed repair (HDR) to maintain telomeric DNA. However, the molecular changes needed for cells to productively engage in telomeric HDR are poorly understood. To gain new insights into this transition, we monitored the state of telomeres during serial culture of fission yeast (Schizosaccharomyces pombe) lacking the telomerase recruitment factor Ccq1. Rad52 is loaded onto critically short telomeres shortly after germination despite continued telomere erosion, suggesting that recruitment of recombination factors is not sufficient to maintain telomeres in the absence of telomerase function. Instead, survivor formation coincides with the derepression of telomeric repeat-containing RNA (TERRA). In this context, degradation of TERRA associated with the telomere in the form of R-loops drives a severe growth crisis, ultimately leading to a novel type of survivor with linear chromosomes and altered cytological telomere characteristics, including the loss of the shelterin component Rap1 (but not the TRF1/TRF2 ortholog, Taz1) from the telomere. We demonstrate that deletion of Rap1 is protective in this context, preventing the growth crisis that is otherwise triggered by degradation of telomeric R-loops in survivors with linear chromosomes. These findings suggest that upregulation of telomere-engaged TERRA, or altered recruitment of shelterin components, can support telomerase-independent telomere maintenance.