bluuebunny/crossref_metadata_2025_split huggingface dataset:
Rendre compte d’une expérience de visite : se dire et se redire dans des entretiens d’explicitation composites
Authors: Wadbled Nathanaël 
Published: June 2019

S’ils ont déjà pu raconter leur visite, les participants à une enquête qui racontent leur expérience touristique s’y replongent généralement pour la première fois de manière aussi intime. Le participant cherche la manière la plus adéquate d’en rendre compte en négociant avec ses compétences linguistiques. L’enjeu est de parvenir à formuler discursivement une épreuve perceptive et affective. L’enquêteur ne doit pas simplement enregistrer ce qu’on lui déclare, mais s’interroger sur ce que le participant veut dire, sans présager la signification des termes utilisés comme étant évidente, ni subsumer les significations données sous les différentes catégories analytiques. C’est à cette condition que peut être menée une évaluation de l’expérience touristique telle qu’elle est vécue par les touristes eux-mêmes et non telle qu’elle est espérée par les acteurs ou analysée par les chercheurs. La technique de l’entretien d’explicitation composite est une réponse à cette problématique : les participants à l’enquête disent et redisent ce qu’ils ont vécu afin de se faire comprendre au mieux.
Maintenance of homeostatic plasticity at the Drosophila neuromuscular synapse requires continuous IP3-directed signaling
Authors: James Thomas D , Zwiefelhofer Danielle J , Frank C Andrew 
Published: June 2019

Synapses and circuits rely on neuroplasticity to adjust output and meet physiological needs. Forms of homeostatic synaptic plasticity impart stability at synapses by countering destabilizing perturbations. The Drosophila melanogaster larval neuromuscular junction (NMJ) is a model synapse with robust expression of homeostatic plasticity. At the NMJ, a homeostatic system detects impaired postsynaptic sensitivity to neurotransmitter and activates a retrograde signal that restores synaptic function by adjusting neurotransmitter release. This process has been separated into temporally distinct phases, induction and maintenance. One prevailing hypothesis is that a shared mechanism governs both phases. Here, we show the two phases are separable. Combining genetics, pharmacology, and electrophysiology, we find that a signaling system consisting of PLCβ, inositol triphosphate (IP3), IP3 receptors, and Ryanodine receptors is required only for the maintenance of homeostatic plasticity. We also find that the NMJ is capable of inducing homeostatic signaling even when its sustained maintenance process is absent.Editorial note: This article has been through an editorial process in which the authors decide how to respond to the issues raised during peer review. The Reviewing Editor's assessment is that all the issues have been addressed (<xref ref-type="decision-letter" rid="SA1">see decision letter</xref>).
Global transcriptomic analysis identifiesSERPINE1as a prognostic biomarker associated with epithelial-to-mesenchymal transition in gastric cancer
Authors: Xu Bodong , Bai Zhigang , Yin Jie , Zhang Zhongtao 
Published: June 2019

BackgroundThe plasminogen activation system plays a pivotal role in regulating tumorigenesis. In this work, we aim to identify key regulators of plasminogen activation associated with tumorigenesis and explore potential mechanisms in gastric cancer (GC).MethodsGene profiling datasets were extracted from the Gene Expression Omnibus (GEO) database. The differentially expressed genes (DEGs) were screened for and obtained by the GEO2R tool. The Database for Annotation, Visualization and Integrated Discovery was used for GO and KEGG enrichment analysis. Gene set enrichment analysis (GSEA) was performed to verify molecular signatures and pathways among The Cancer Genome Atlas or GEO datasets. Correlations between SERPINE1 and markers of epithelial-to-mesenchymal transition (EMT) were analyzed using the GEPIA database and quantitative real-time PCR (qRT-PCR). Interactive networks of selected genes were built by STRING and Cytoscape software. Finally, selected genes were verified with the Kaplan–Meier (KM) plotter database.ResultsA total of 104 overlapped upregulated and 61 downregulated DEGs were obtained. Multiple GO and KEGG terms associated with the extracellular matrix were enriched among the DEGs. SERPINE1 was identified as the only regulator of angiogenesis and the plasminogen activator system among the DEGs. A high level of SERPINE1 was associated with a poor prognosis in GC. GSEA analysis showed a strong correlation between SERPINE1 and EMT, which was also confirmed with the GEPIA database and qRT-PCR validation. FN1, TIMP1, MMP2, and SPARC were correlated with SERPINE1.The KM plotter database showed that an overexpression of these genes correlated with a shorter survival time in GC patients.ConclusionsIn conclusion, SERPINE1 is a potent biomarker associated with EMT and a poor prognosis in GC. Furthermore, FN1, TIMP1, MMP2, and SPARC are correlated with SERPINE1 and may serve as therapeutic targets in reversing EMT in GC.
Coelomic Fluid Evaluation in Clinically Normal Ochre Sea Stars Pisaster ochraceus: Cell Counts, Cytology, and Biochemistry Reference Intervals
Authors: Wahltinez Sarah J. , Stacy Nicole I. , Lahner Lesanna L. , Newton Alisa L. 
Published: June 2019

Abstract
Coelomic fluid sampling is a noninvasive technique that is used to access the body fluid of sea stars for diagnostics and research. Given recent mortality events including sea star wasting disease, which has killed millions of sea stars along the Pacific coast since 2013, there is a need for validated diagnostic tests to evaluate sea star health. The objectives of this study were to establish coelomic fluid reference intervals for clinically normal ochre sea stars Pisaster ochraceus in an open system aquarium, to describe the cytologic findings, and to compare the chemistries of coelomic fluid with open system tank water. Coelomic fluid from 26 clinically normal sea stars was sampled for coelomocyte counts, cytologic evaluation, and biochemical analysis including magnesium, sodium, potassium, chloride, calcium, and total protein. The number of coelomocytes and total protein did not fit normal distribution and were excluded from analyses. Reference intervals were established for other chemistry analytes. There was no statistical difference in biochemistries between sea star coelomic fluid and water from five open system tanks, which supports previous evidence that sea stars are osmoconformers. Very low numbers of coelomocytes were observed cytologically. These results provide a useful baseline and diagnostic tool for health assessments of sea stars.
Tumor Microenvironment‐Responsive Dual Drug Dimer‐Loaded PEGylated Bilirubin Nanoparticles for Improved Drug Delivery and Enhanced Immune‐Chemotherapy of Breast Cancer
Authors: Yang Xiaotong , Hu Chuan , Tong Fan , Liu Rui , Zhou Yang , Qin Lin , Ouyang Liang , Gao Huile 
Published: June 2019

AbstractThe application of combinational therapy makes up for the limitation of monotherapy and achieves superior treatment against cancer. However, the combinational therapy remains restricted by the poor tumor‐specific delivery and the abscopal effect. Herein, reactive oxygen species (ROS)‐responsive PEGylated bilirubin nanoparticles (BRNPs) are developed to encapsulate two glutathione‐activatable drugs, including dimer‐7‐ethyl‐10‐hydroxycamptothecin (d‐SN38) and dimer‐lonidamine (d‐LND). Dimerization of the drugs significantly increases the drug loading capacity and the encapsulation efficiency of nanoparticles. With the assistance of iRGD peptide (cRGDKGPDC), the cellular uptake of BRNPs is more than double when compared with the control. In response to high levels of intracellular ROS, d‐SN38 and d‐LND are rapidly released from nanoparticles (SL@BRNPs). Furthermore, the pharmacodynamic experiments verify combining SL@BRNPs with anti‐PD‐L1 antibody greatly inhibits the primary tumor of breast cancer, improves CD8+ T cells levels, and CD8+ T cells/Tregs ratios in the tumor. Additionally, it shows high immune memory effect and can prevent the growth of lung metastasis. Taken together, the strategy pioneers a new way for the rational design of nanoassemblies through the combination of activatable drug dimers and stimuli‐responsive drug release, and a successful application of novel drug delivery systems in combination with the immune checkpoint blockade antibody.
A General Synthesis of Crumpled Metal Oxide Nanosheets as Superior Chemiresistive Sensing Layers
Authors: Kim Rheehyun , Jang Ji‐Soo , Kim Dong‐Ha , Kang Joon‐Young , Cho Hee‐Jin , Jeong Yong Jin , Kim Il‐Doo 
Published: June 2019

AbstractMetal oxide nanosheets having high mesoporosity, grain size distribution of 5–10 nm, and ultrathin thickness have attracted much attention due to their intriguing properties such as high surface‐to‐volume ratio and superior chemical activities. However, 2D nanostructures tend to restack, inducing a decrease in accessible surface area and a number of pores. To solve this problem, herein, a unique synthetic method of crumpled metal oxide nanosheets using spray pyrolysis of metal ion–coated graphene oxide, followed by heat treatment, is reported. This method is applicable not only to single‐component metal oxides but also to heterogeneous multicomponent metal oxides in which composition can be controlled. Crumpled SnO2, ZnO, and Co3O4 as well as SnO2/ZnO and SnO2/Co3O4 nanosheets with heterogeneous interfaces are successfully synthesized and used as superior gas sensing layers. Because of the abundant reaction sites, well‐developed porosity for high gas accessibility, the formation of heterojunctions, the crumpled SnO2/ZnO and SnO2/Co3O4 nanosheets exhibit outstanding sensing performance (Rair/Rgas = 20.25 toward 5 ppm formaldehyde, and Rair/Rgas = 14.13 toward 5 ppm acetone, respectively). This study can contribute to the realization of a family of heterogeneous crumpled metal oxide nanosheets that can be applied to various research fields.
Layered Germanium Hybrid Perovskite Bromides: Insights from Experiments and First‐Principles Calculations
Authors: Chang Xueqing , Marongiu Daniela , Sarritzu Valerio , Sestu Nicola , Wang Qingqian , Lai Stefano , Mattoni Alessandro , Filippetti Alessio , Congiu Francesco , Lehmann Alessandra Geddo , Quochi Francesco , Saba Michele , Mura Andrea , Bongiovanni Giovanni 
Published: June 2019

AbstractMetal halide perovskites are maturing as materials for efficient, yet low cost solar cells and light‐emitting diodes, with improving operational stability and reliability. To date however, most perovskite‐based devices contain Pb, which poses environmental concerns due to its toxicity; lead‐free alternatives are of importance to facilitate the development of perovskite‐based devices. Here, the germanium‐based Ruddledsen–Popper series (CH3(CH2)3NH3)2(CH3NH3)n−1GenBr3n+1 is investigated, derived from the parent 3D (n = ∞) CH3NH3GeBr3 perovskite. Divalent germanium is a promising, nontoxic alternative to Pb2+ and the layered, 2D structure appears promising to bolster light emission, long‐term durability, and moisture tolerance. The work, which combines experiments and first principle calculations, highlights that in germanium bromide perovskites the optical bandgap is weakly affected by 2D confinement and the highly stereochemically active 4s2 lone pair preludes to possible ferroelectricity, a topic still debated in Pb‐containing compounds.
Co Nanoislands Rooted on Co–N–C Nanosheets as Efficient Oxygen Electrocatalyst for Zn–Air Batteries
Authors: Yu Peng , Wang Lei , Sun Fanfei , Xie Ying , Liu Xu , Ma Jingyuan , Wang Xiuwen , Tian Chungui , Li Jinghong , Fu Honggang 
Published: June 2019

AbstractDeveloping non‐precious‐metal bifunctional oxygen reduction and evolution reaction (ORR/OER) catalysts is a major task for promoting the reaction efficiency of Zn–air batteries. Co‐based catalysts have been regarded as promising ORR and OER catalysts owing to the multivalence characteristic of cobalt element. Herein, the synthesis of Co nanoislands rooted on Co–N–C nanosheets supported by carbon felts (Co/Co–N–C) is reported. Co nanosheets rooted on the carbon felt derived from electrodeposition are applied as the self‐template and cobalt source. The synergistic effect of metal Co islands with OER activity and Co–N–C nanosheets with superior ORR performance leads to good bifuctional catalytic performances. Wavelet transform extended X‐ray absorption fine spectroscopy and X‐ray photoelectron spectroscopy certify the formation of Co (mainly Co0) and the Co–N–C (mainly Co2+ and Co3+) structure. As the air‐cathode, the assembled aqueous Zn–air battery exhibits a small charge–discharge voltage gap (0.82 V@10 mA cm−2) and high power density of 132 mW cm−2, outperforming the commercial Pt/C catalyst. Additionally, the cable flexible rechargeable Zn–air battery exhibits excellent bendable and durability. Density functional theory calculation is combined with operando X‐ray absorption spectroscopy to further elucidate the active sites of oxygen reactions at the Co/Co–N–C cathode in Zn–air battery.
Scalable Fabrication of Porous Microchannel Nerve Guidance Scaffolds with Complex Geometries
Authors: Shahriari Dena , Loke Gabriel , Tafel Ian , Park Seongjun , Chiang Po‐Han , Fink Yoel , Anikeeva Polina 
Published: June 2019

AbstractMicrochannel scaffolds accelerate nerve repair by guiding growing neuronal processes across injury sites. Although geometry, materials chemistry, stiffness, and porosity have been shown to influence nerve growth within nerve guidance scaffolds, independent tuning of these properties in a high‐throughput manner remains a challenge. Here, fiber drawing is combined with salt leaching to produce microchannels with tunable cross sections and porosity. This technique is applicable to an array of biochemically inert polymers, and it delivers hundreds of meters of porous microchannel fibers. Employing these fibers as filaments during 3D printing enables the production of microchannel scaffolds with geometries matching those of biological nerves, including branched topographies. Applied to sensory neurons, fiber‐based porous microchannels enhance growth as compared to non‐porous channels with matching materials and geometries. The combinatorial scaffold fabrication approach may advance the studies of neural regeneration and accelerate the development of nerve repair devices.
Polymeric Microneedle Arrays: Versatile Tools for an Innovative Approach to Drug Administration
Authors: Dardano Principia , Battisti Mario , Rea Ilaria , Serpico Luigia , Terracciano Monica , Cammarano Aniello , Nicolais Luigi , De Stefano Luca 
Published: June 2019

AbstractMainly designed and realized as a painless alternative to the hypodermic syringe, microneedle‐based devices are currently approaching commercial market placement. The considerable academic and industrial investment in this technology is reflected by a multitude of papers published and patents registered every year, which is also a sign of a field in full fermentation. New materials and innovative methodologies are continuously exploited in search of the best performance at the lowest cost. For these reasons, an updated review, focused predominantly on the last year of scientific production, is a useful guideline in this rapidly changing panorama. This report provides a critical review of microneedle technologies presented in the very recent literature with a particular focus on those closest to the needs of the healthcare field. Although a few devices are already commercial, further effort is still needed to achieve complete clinical translation and therapeutic efficacy competitive with or superior to those of the devices used as standards and adopted by national health systems.
Mimicking the Dissolution Mechanisms of pH‐Responsive Drug Release Formulations in Atomistic MD Simulations
Authors: Katiyar Ratna S. , Jha Prateek K. 
Published: June 2019

AbstractAtomistic molecular dynamics (MD) simulations of poly(acrylic acid) (PAA)‐doxorubicin (DOX) formulations dissolved in water are performed to mimic three common drug release mechanisms of pH‐responsive polymer–drug formulations. The effect of formulation matrix swelling in a reverse manner is mimicked by performing sequential water removal during the MD simulations followed by re‐equilibration, until an amorphous state devoid of water is achieved. Then, MD simulations for different PAA and DOX compositions are performed that mimic the different dissolution stages of an eroding and non‐swellable matrix, respectively. An Arrhenius law dependence of diffusion coefficient is established on the changes in PAA–DOX interaction energy, which in turn shows power law dependence on concentration. Together, the three sets of simulations demonstrate how the molecular‐level interactions (e.g., hydrogen bonding, ionic complexation) drive macroscopic changes in the drug release behavior described in terms of drug/water diffusion coefficients, and also highlight the potential of atomistic simulations in the prediction of drug release behavior of novel polymer–drug formulations using the diffusion coefficients obtained in atomistic simulations.
Commercialization of Lithium Battery Technologies for Electric Vehicles
Authors: Zeng Xiaoqiao , Li Matthew , Abd El‐Hady Deia , Alshitari Wael , Al‐Bogami Abdullah S. , Lu Jun , Amine Khalil 
Published: June 2019

AbstractThe currently commercialized lithium‐ion batteries have allowed for the creation of practical electric vehicles, simultaneously satisfying many stringent milestones in energy density, lifetime, safety, power, and cost requirements of the electric vehicle economy. The next wave of consumer electric vehicles is just around the corner. Although widely adopted in the vehicle market, lithium‐ion batteries still require further development to sustain their dominating roles among competitors. In this review, the authors survey the state‐of‐the‐art active electrode materials and cell chemistries for automotive batteries. The performance, production, and cost are included. The advances and challenges in the lithium‐ion battery economy from the material design to the cell and the battery packs fitting the rapid developing automotive market are discussed in detail. Also, new technologies of promising battery chemistries are comprehensively evaluated for their potential to satisfy the targets of future electric vehicles.
General Synthesis of Ultrathin Metal Borate Nanomeshes Enabled by 3D Bark‐Like N‐Doped Carbon for Electrocatalysis
Authors: Hu Qi , Li Guomin , Han Zhen , Wang Ziyu , Huang Xiaowan , Chai Xiaoyan , Zhang Qianling , Liu Jianhong , He Chuanxin 
Published: June 2019

AbstractUltrathin nanomeshes perfectly inherit the integrated advantages of ultrathin 2D materials and porous nanostructures, which have shown their great application potential in catalysis and electronic devices. Here, the general synthesis of ultrathin metal borate (i.e., Co‐Bi, Ni‐Bi, and Fe‐Bi) nanomeshes is reported by capitalizing on 3D bark‐like N‐doped carbon (denoted BNC) as nanoreactors. Indeed, this strategy is straightforward, only comprising a one‐step reaction between metal cations and sodium borohydride without using templates. As nanoreactors, the BNC derived from biomass waste of lychee exocarp possesses distinctive advantages of low cost, fractured textures, porous nanostructures (surface area: 1915.5 m2 g−1), electronegative surface (zeta potential: −43.4 mV), and superhydrophilicity for greatly facilitating the adsorption of metal cations with strong strength to effectively control the growth of 2D nanomeshes. The as‐synthesized Co‐Bi and Ru‐doped Co‐Bi (Ru‐Co‐Bi) nanomeshes exhibit excellent performance for the oxygen evolution reaction and hydrogen evolution reaction, respectively. Impressively, the water splitting device based on the Co‐Bi and Ru‐Co‐Bi nanomeshes can enable a current density of 10 mA cm−2 at a small cell voltage of 1.53 V. Therefore, this work paves new avenues for the facile synthesis of ultrathin metal nanomeshes.
Serial fractional exhaled nitric oxide measurements off and at work in the diagnosis of occupational asthma
Authors: van Kampen Vera , Brüning Thomas , Merget Rolf 
Published: June 2019

AbstractBackgroundFractional exhaled nitric oxide (FeNO) before and after specific inhalation challenge has been postulated as an additional tool in the diagnosis of occupational asthma (OA), but little is known about serial FeNO measurements at home and at work. The aim of the present study was to assess the contribution of serial measurements of FeNO off and at work toward the diagnosis of OA.MethodsForty‐one subjects with suspected (n = 35) or diagnosed (n = 6) OA performed FeNO measurements once daily during a 2‐week holiday and a subsequent 2‐week work period. A work‐related increase in FeNO by 20 ppb (parts per billion) or more was considered positive. Subjects with negative or doubtful specific inhalation challenge but a FeNO increase of 20 ppb or more were evaluated individually by an overall expert rating taking into account all available information.ResultsSeven of 35 subjects (20%) with suspected and three of six subjects (50%) with diagnosed OA showed a work‐related FeNO increase of 20 ppb or more. Six of the seven with suspected OA were reclassified as having an OA diagnosis by the overall expert rating which also considered these FeNO changes.ConclusionsSerial FeNO measurements off and at work provide complementary information in the diagnosis in about one‐fifth of cases with suspected OA, especially if specific inhalation challenges are negative or cannot be performed.
Molecular Design of a New Diboronic Acid for the Electrohydrodynamic Monitoring of Glucose
Authors: Wang Bing , Chou Kuang‐Hua , Queenan Bridget N. , Pennathur Sumita , Bazan Guillermo C. 
Published: June 2019

AbstractA new dicationic diboronic acid structure, DBA2+, was designed to exhibit good affinity (Kd≈1 mm) and selectivity toward glucose. Binding of DBA2+ to glucose changes the pKa of DBA2+ from 9.4 to 6.3, enabling opportunities for detection of glucose at physiological pH. Proton release from DBA2+ is firmly related to glucose concentrations within the physiologically relevant range (0–30 mm), as verified by conductimetric monitoring. Negligible interference from other sugars (for example, maltose, fructose, sucrose, lactose, and galactose) was observed. These results demonstrate the potential of DBA2+ for selective, quantitative glucose sensing. The nonenzymatic strategy based on electrohydrodynamic effects may enable the development of stable, accurate, and continuous glucose monitoring platforms.
Organic–inorganic hybrid of anchored dicationic ionic liquid on Al‐MCM‐41‐phosphovanadomolybdate toward selective oxidation of benzene to phenol
Authors: Taheri Masoud , Ghiaci Mehran , Moheb Ahmad , Shchukarev Andrey 
Published: June 2019

A phosphovanadomolybdate hybridized with an anchored dicationic ionic liquid on Al‐MCM‐41 was prepared through the anion exchange and characterized by 1H and 13C NMR, FTIR, UV–Vis, XRD, XPS, TGA, TEM, FESEM, ICP‐OES and BET techniques. The obtained data demonstrated that the composite is a porous material with the high surface area and also having a large pore volume which are 405 m2 g−1 and 0.616 cm3 g−1 respectively. The prepared composite has shown an acceptable catalytic activity for converting benzene selectively to phenol with hydrogen peroxide as eco‐friendly oxidant. Under the optimized reaction conditions, the hybrid catalyst resulted in phenol yield of 14.8% with 100% selectivity and a TOF value of 20.0 h−1. The catalyst also revealed a desired recovery and reusability. The efficient performance of the composite is related to the textural and polyoxometalate properties.