bluuebunny/crossref_metadata_2025_split huggingface dataset:
The impact of psoriasis on professional life: PsoPRO, a French national survey
Authors: Claudepierre P. , Lahfa M. , Levy P. , Barnetche T. , Bonnet I. , Aubert R. , Roquelaure Y. 
Published: April 2018

AbstractBackgroundThe physical, social and mental burden of psoriasis is well known, but its occupational impact has been less investigated.ObjectiveTo assess the impact of psoriasis on the working life of patients compared with the general population.MethodsA national survey compared people with and without psoriasis using online questionnaires. In addition to the demographic, medical and professional characteristics, data on recent absenteeism and presenteeism were captured using the validated WPAI‐PSO questionnaire.ResultsThe patient sample comprised 714 with psoriasis (PsO), including 81 treated with systemic therapies (PsoST), and 84 with associated psoriatic arthritis (PsO + PsA). The control sample comprised 604 active subjects representative of the French population. Compared to controls, the impact of the disease on working life was no greater in PsO patients. Conversely, unemployment within the past 5 years and mean number of sick leaves within the previous year were more frequent in PsO + PsA. In patients with active psoriasis skin lesions, all aspects of the WPAI questionnaire were negatively impacted in PsoST and PsO + PsA patients, but not in PsO patients: Levels of absenteeism were 3.3% in controls, 5.6% in PsO (NS), 8.3% in PsoST (P < 0.05) and 13.0% in Ps0 + PsA (P < 0.05); impairment in presenteeism reached 27.0%, 21.2% (NS), 43.5% (P < 0.05) and 53.2% (P < 0.05), respectively, while overall work impairment was 27.9%, 22.2% (NS), 46.3% (P < 0.05) and 57.6% (P < 0.05), respectively. Nevertheless, a higher proportion of PsoST and PsO + PsA patients reported that work was more important than any other activity in their life.ConclusionThe occupational impact of psoriasis is important and significant in patients who receive systemic therapy or have concurrent PsA but minimal or absent in other psoriasis patients. The findings show that psoriasis patients have a high level of motivation to work.
Study on 3D printing of orange concentrate and material characteristics
Authors: Azam S. M. Roknul , Zhang Min , Mujumdar Arun S. , Yang Chaohui 
Published: April 2018

AbstractThree‐dimensional (3D) food printing is a promising technology that attracted the attention of both academia and industry since it is considered as a major paradigm shift in the fabrication of intricate and personalized food design with the choices of altering the nutritional profile. In this study, 3D printing (3DP) properties of orange leather (OL) were characterized and simultaneously comparative assessment was carried out while making it from orange concentrate (OC) by adding varying proportions (15, 20, 25, and 30%) of wheat starch (WS). Rheological data suggest that steam cooking of OC–WS mixture for 16 ± 0.5 min exhibit shear‐thinning behavior, which is essential for extrusion‐type 3DP of food mixtures. A variation of 5% WS with OC significantly increase the yield stress (τ0) and viscosity (n). Nuclear magnetic resonance (NMR) study revealed that the maximum amount of partially immobilized water was converted to bound water and developed the highest mechanical strength but poor extrudability for 30% WS containing sample. Texture profile analysis suggests that the 20% WS containing samples provide the best mastication properties among the four samples. To optimize the printing conditions and test the reproducibility of OL 3DP process effects of nozzle diameter (dn), nozzle tip‐print bed height (hc), extrusion rate (vd), and nozzle moving speed (vn) were tested experimentally. It was found that, at dn = 1.5 mm, hc = 1.54 ± 0.02 mm, vd = 245 mm3/s, and vn = 35 mm/s the printed objects remain consistent, achieve the best resolution and maximum fidelity.Practical applicationsThe 3D food printing process has a great potential to improve the quality and utility of the food and food products. The 3DP of fruit concentrates combined with healthy additives, bioactive compounds could be a novel attractive way for fabricating food to serve people with special requirements, as a snack item or cold dish before main meal. This study suggests that, food mixtures with similar rheological, moisture, and textural properties at similar printing conditions could be used as supply material, that is, the “ink” for an extrusion‐type 3D food printer.
Detection of toxin genes and randomly amplified polymorphic DNA typing of Bacillus cereus isolates from infant milk formulas
Authors: Lepsanovic Zorica , Djordjevic Vesna , Lakicevic Brankica , Savic Dejana , Velebit Branko , Josic Dragana , Karabasil Nedjeljko 
Published: April 2018

AbstractBacillus cereus, a ubiquitous human foodborne pathogen, can persist in different environment, including dry conditions. In this study, we explored the genetic diversity of B. cereus isolates from infant milk formulas. Out of 83 samples, B. cereus was confirmed in 26 (31.3%). Isolates were resistant to penicillin G and ampicillin (100%), trimethoprim‐sulfamethoxazole (84.6%), and erythromycin (3.8%). Ent, hbl, and cer genes were detected in 21 (80.8%), 2 (7.7%), and 11 (42.3%) isolates, respectively. Randomly amplified polymorphic DNA (RAPD) analysis, using set of three primers, provided an overall genetic distance of 95% between B. cereus isolates. A group of seven emetic strains and another two enterotoxic strains were indistinguishable by RAPD, revealing their high clonality. In conclusion, we detected a high proportion of pathogenic B. cereus isolates in infant milk formulas. The majority of isolates harboring both cer and ent genes showed high clonality, pointing food processing environment as probable contamination source.Practical applicationsDetection of Bacillus cereus in powdered infant milk formulas, the prevalence of emetic and diarrhegenic genes, and especially the simultaneous presence of both types of genes in the same isolate, confirm the importance of B. cereus as foodborne pathogen. The consumption of contaminated formula may cause serious health problems in babies, which emphasizes the need to improve B. cereus monitoring and characterization. The clonal relationship between strains, revealed by RAPD analysis, may point to the source of infection and the corresponding prevention measures to improve food safety. Moreover, the identical RAPD profile of cer positive strains obtained with AG15 primer enables the application of this analysis in screening for emetic B. cereus isolates.
Wisteria floribunda agglutinin‐positive Mac‐2‐binding protein and type 4 collagen 7S: useful markers for the diagnosis of significant fibrosis in patients with non‐alcoholic fatty liver disease
Authors: Ogawa Yuji , Honda Yasushi , Kessoku Takaomi , Tomeno Wataru , Imajo Kento , Yoneda Masato , Kawanaka Miwa , Kirikoshi Hiroyuki , Ono Masafumi , Taguri Masataka , Saito Satoru , Yamanaka Takeharu , Wada Koichiro , Nakajima Atsushi 
Published: April 2018

AbstractBackground and AimThe fibrosis stage of liver is associated with the long‐term outcomes in patients with non‐alcoholic fatty liver disease (NAFLD). However, significant fibrosis, defined as fibrosis stages 2–4, is associated with an elevated risk of progression to severe liver disease; there have been scant reports about diagnosing significant fibrosis. We compare the noninvasive method and aim to identify appropriate liver fibrosis markers for detecting significant fibrosis in NAFLD patients.MethodsWe compared the usefulness of liver fibrosis markers (Wisteria floribunda agglutinin‐positive Mac‐2‐binding protein [WFA+‐M2BP], type 4 collagen 7S, etc.), clinical scoring systems, and liver stiffness measurement obtained using vibration‐controlled transient elastography and magnetic resonance imaging‐based magnetic resonance elastography in the same individuals and identified the most appropriate noninvasive method for detecting significant fibrosis in 165 patients with liver biopsy‐diagnosed NAFLD.ResultsThe area under the receiver operating characteristic curve based on the serum cutoff index values of WFA+‐M2BP/the serum levels of type IV collagen 7S for the diagnosis of significant fibrosis was 0.832 (95% confidence interval: 0.771–0.894)/0.837 (95% confidence interval: 0.778–0.898). “WFA+‐M2BP (cutoff index) ≥ 0.83 or type IV collagen 7S ≥ 5.2 ng/mL” showed a high sensitivity (91.4%) and negative predictive value (87.9%) for the diagnosis of significant fibrosis.ConclusionsWe showed that serum WFA+‐M2BP or type IV collagen 7S levels serve as useful independent markers for detecting significant fibrosis and that use of both WFA+‐M2BP and type IV collagen 7S together increased the sensitivity and negative predictive value for the diagnosis of liver fibrosis. These results need to be validated in larger populations from multiple clinical centers.
The anatomy and physiology of the terminal thoracic duct and ostial valve in health and disease: potential implications for intervention
Authors: Ratnayake Chathura Bathiya Bandara , Escott Alistair Brian James , Phillips Anthony Ronald John , Windsor John Albert 
Published: April 2018

AbstractThe thoracic duct (TD) transports lymph drained from the body to the venous system in the neck via the lymphovenous junction. There has been increased interest in the TD lymph (including gut lymph) because of its putative role in the promotion of systemic inflammation and organ dysfunction during acute and critical illness. Minimally invasive TD cannulation has recently been described as a potential method to access TD lymph for investigation. However, marked anatomical variability exists in the terminal segment and the physiology regarding the ostial valve and terminal TD is poorly understood. A systematic review was conducted using three databases from 1909 until May 2017. Human and animal studies were included and data from surgical, radiological and cadaveric studies were retrieved. Sixty‐three articles from the last 108 years were included in the analysis. The terminal TD exists as a single duct in its terminal course in 72% of cases and 13% have multiple terminations: double (8.5%), triple (1.8%) and quadruple (2.2%). The ostial valve functions to regulate flow in relation to the respiratory cycle. The patency of this valve found at the lymphovenous junction opening, is determined by venous wall tension. During inspiration, central venous pressure (CVP) falls and the valve cusps collapse to allow antegrade flow of lymph into the vein. During early expiration when CVP and venous wall tension rises, the ostial valve leaflets cover the opening of the lymphovenous junction preventing antegrade lymph flow. During chronic disease states associated with an elevated mean CVP (e.g. in heart failure or cirrhosis), there is a limitation of flow across the lymphovenous junction. Although lymph production is increased in both heart failure and cirrhosis, TD lymph outflow across the lymphovenous junction is unable to compensate for this increase. In conclusion the terminal TD shows marked anatomical variability and TD lymph flow is controlled at the ostial valve, which responds to changes in CVP. This information is relevant to techniques for cannulating the TD, with the aid of minimally invasive methods and high resolution ultrasonography, to enable longitudinal physiology and lymph composition studies in awake patients with both acute and chronic disease.
Use of cosmetic products for treating certain diseases—Know the science
Authors: Aruna V , Amruthavalli G V , Gayathri R 
Published: April 2018

SummaryBackgroundPsoriasis being an incurable disease, the drug dependency of the patient in most occasions causes greater health problem than psoriasis. Wherever there is flare‐up, immunosuppressive drugs and other antimitotic medicaments are necessary. Therefore, a safe cosmetic preparation with drug‐like effect on certain triggering factors of psoriasis may revolutionize the treatment.ObjectivesObjectives of this study were to determine the effect of the developed formulation on several key enzymes such as lipoxygenase, collagenase, elastase, and nullifying the free radicals and glycation. All these enzymes have cascading effect in triggering the problem to inflammatory level.MethodsBiochemical and enzymatic assay was performed to determine the effect of the cosmetic formulation and its effective dosage.ResultThe findings clearly show that the formulation is effective against all the key triggering factors of psoriasis.ConclusionFindings undoubtedly establish the drug‐like effect of nondrug formulation (cosmetic formulation). The use of this formulation may minimize the relative dependency of many steroids and other medicament. As the formulation contains only proven cosmetic ingredients and herbs, long‐term use is unlikely to produce any side effects.
Psycho‐cognitive predictors of burnout in healthcare professionals working in emergency departments
Authors: Masiero Marianna , Cutica Ilaria , Russo Selena , Mazzocco Ketti , Pravettoni Gabriella 
Published: April 2018

BackgroundHealthcare professionals working in emergency departments commonly experience high work pressure and stress due to witnessing human suffering and the unpredictable nature of the work. Several studies have identified variables that affect burnout syndrome, but poor data are available about the predictors of the different dimensions of burnout (depersonalisation, emotional exhaustion, professional inefficacy and disillusionment). Some research has suggested that alexithymia, coping style and decision‐making style may predict burnout.DesignWe conducted a noninterventional study to investigate whether and how alexithymia, coping style and decision‐making style are associated with the different dimensions of burnout.MethodsWe recruited a convenience sample of 93 healthcare professionals working in an Italian emergency departments. Participants completed a questionnaire assessing their level of burnout (the Link Burnout Questionnaire), and possible burnout predictors: decision‐making style, alexithymia and the coping style. Four bivariate linear regressions were performed to define the predictors that characterised the dimensions of burnout.ResultsWe found that an avoidant decision‐making style and a difficulty to identify and describe feelings (a difficulty close to alexithymia even though not as severe) are strong predictors of some burnout dimensions. Individuals who experience relational depersonalisation are more likely to turn to religion as a way to cope.ConclusionsOur research shows that, to some extent, difficulties in emotion regulation and the attitude to avoid or postpone decisions characterised burnout.Relevance to clinical practiceThese results might be used to develop tailored psycho‐educational interventions. This might help healthcare professionals to develop personal skills to cope with the critical conditions that characterise their work and to enable them to recognise potential risk factors that favour burnout. This has pivotal implications for the maintenance of the patient–healthcare professional relationship and in reducing clinical errors.
Missed nursing care and its relationship with confidence in delegation among hospital nurses
Authors: Saqer Tahani J , AbuAlRub Raeda F 
Published: April 2018

Aims and ObjectivesTo (i) identify the types and reasons for missed nursing care among Jordanian hospital nurses; (ii) identify predictors of missed nursing care based on study variables; and (iii) examine the relationship between nurses’ confidence in delegation and missed nursing care.BackgroundMissed nursing care is a global concern for nurses and nurse administrators. Investigating the relation between the confidence in delegation and missed nursing care might help in designing strategies that enable nurses to minimise missed care and enhance quality of services.MethodsA correlational research design was used for this study. A convenience sample of 362 hospital nurses completed the missed nursing care survey, and confidence and intent to delegate scale.ResultsThe results of the study revealed that ambulating and feeding patients on time, doing mouth care and attending interdisciplinary care conferences were the most frequent types of missed care. The mean score for missed nursing care was (2.78) on a scale from 1–5. The most prevalent reasons for missed care were “labour resources, followed by material resources, and then communication”. Around 45% of the variation in the perceived level of “missed nursing care” was explained by background variables and perceived reasons for missed nursing. However, the relationship between confidence in delegation and missed care was insignificant.ConclusionThe results of this study add to the body of international literature on most prevalent types and reasons for missed nursing care in a different cultural context.Relevance to clinical practiceHighlighting most prevalent reasons for missed nursing care could help nurse administrators in designing responsive strategies to eliminate or reduces such reasons.
The centrality of the nurse–patient relationship: A Scandinavian perspective
Authors: Uhrenfeldt Lisbeth , Sørensen Erik Elgaard , Bahnsen Iben Bøgh , Pedersen Preben Ulrich 
Published: April 2018

Aims and objectivesTo address aspects of importance in the nurse–patient relationship, as conceptualised within the Scandinavian healthcare context.BackgroundAn experiment in Beth Israel Hospital uncovered a set of core values (ontology) that were wiped away by stronger forces. Despite this, some of the ideas impacted the development of nursing thought and values in the Scandinavian countries, partly because they connected with deeper social values and also because investment was being put into explicitly identifying and understanding the core elements of nursing (ontology) and how to provide evidence that they found were important (epistemology). From that beginning and through the work of key thought leaders, Scandinavian nursing is ready to embark on a new phase, which could be helped by the Fundamentals of Care framework.DesignThis discursive position study offers insights from a public healthcare setting, influenced by values such as equal rights to equal care and/or cure. This study presents two complementing perspectives: an ontological and an epistemological, on establishing caring relationships.ConclusionThere are different pathways to follow in building person‐oriented care; however, the nursing approach is both ontologically and epistemologically grounded and based on dialogue.Relevance to clinical practicePatients meet different nurses, the meeting may be short and, routine actions may be on the agenda. However, nurses must engage with patients’ experiences and knowledge, in order to add to patients’ present and future well‐being with their person‐oriented care.
Understanding regime divergence in the post‐uprising Arab states
Authors: Hinnebusch Raymond 
Published: April 2018

AbstractDespite the fact that democracy was a main demand of the protestors who spearheaded the Arab uprisings, five years later only Tunisia qualifies as democratic while elsewhere the outcomes have been either authoritarian restoration or failing states. This paper seeks to understand these three divergent trajectories in the post‐uprising Arab states, with Tunisia, Egypt and Syria taken as representative of each.
Hydroxypropyl-β-cyclodextrin-containing hydrogel enhances skin formononetin permeation/retention
Authors: Dias Paula Hollweg , Scopel Marina , Martiny Simony , Bianchi Sara Elis , Bassani Valquiria Linck , Zuanazzi José Angelo Silveira 
Published: April 2018

Abstract

Objectives
This study was aimed to investigate the in vitro permeation potential of hydrogel formulations containing the isoflavones formononetin and biochanin A and cyclodextrins in different combinations.

Methods
The permeation assay was performed using porcine skin discs on Franz diffusion cells model. The isoflavone contents of the formulations were quantified in the different layers of the skin using a validated HPLC-PDA method.

Key findings
The isoflavones individually incorporated into the formulations showed high permeation potential, especially formononetin, after the incorporation of hydroxypropyl-β-cyclodextrin that enhanced its permeation in the epidermis and dermis. Biochanin A showed 2.7 times of permeation capacity in the epidermis and dermis mainly after incorporation of cyclodextrins in the formulations. Formononetin showed reduction in its permeation when incorporated in the formulations together to biochanin A, showing the absence of synergism.

Conclusions
Our results indicated a noticeable skin permeation promoting effect of HPβCD in formononetin formulation. Furthermore, formononetin and biochanin A can permeate the skin being mostly retained in the epidermis and dermis, revealing its potential use in cosmetic preparations intended to prevent skin aging.
Effects of lidocaine and the inclusion complex with 2-hydroxypropyl-β-cyclodextrin on cell viability and proliferation of oral squamous cell carcinoma
Authors: Ferreira Luiz E N , Antunes Gabriela B M , Muniz Bruno V , Burga-Sánchez Jonny , de Melo Nathalie F S , Groppo Francisco C , Fraceto Leonardo F , Volpato Maria C 
Published: April 2018

Abstract

Objectives
Squamous cell carcinoma (SCC) is a malignant disease that affects the oral cavity. Lidocaine has shown antiproliferative and cytotoxic activity on several cell types. The rapid dispersion is a limitation issue; however, the complexation in cyclodextrin improved pharmacological features and modified the drug release. This study investigated the effects of lidocaine (lido) complexed with 2-hydroxypropyl-β-cyclodextrin (HP-β-CD-lido) on cell viability and proliferation of human tongue squamous cell carcinoma SCC9 and SCC25.

Methods
The complex formation was confirmed by differential scanning calorimetry (DSC) and scanning electron microscopy (SEM). Cells SCC9 and SCC25 were exposed to lido and HP-β-CD-lido (40–4000 μm), and the effects on cell viability (MTT) and antiproliferative activity (SRB) were tested.

Key findings
Differential scanning calorimetry and SEM results demonstrated the occurrence of host–guest interaction. Lido and HP-β-CD-lido (4000 μm) significantly reduced the viability of SCC9 cells to 83% and 63%, respectively. The viability of SCC25 treated with lido, and HP-β-CD-lido (4000 μm) was 71% and 44%, respectively. Lido (4000 μm) reduced the proliferation of SCC9 and SCC25 to 39.5% and 23.7%, respectively. HP-β-CD-lido (4000 μm) was cytotoxic for both cell lines.

Conclusions
HP-β-CD was able to potentiate the in vitro cytotoxic effects of lidocaine on human squamous cell carcinoma.