bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessment of joint health in females with haemophilia: The carriers ultrasound project (CUP) study
Authors: Corrales‐Medina Fernando F. , Fraga Kelli , D'Almeida Bastos Maria , Rafique Amina , Kempton Christine L. , Vijayvargia Pooja , Davis Joanna A. , Kronenfeld Rachel S. 
Published: November 2024

AbstractIntroductionThe needs of haemophilia carriers (HC) have been historically overlooked. It is now recognised that HC manifests bleeding symptoms, including haemarthrosis. The natural history of joint health in HC is not yet defined.AimA multi‐institutional cross‐sectional study aimed to evaluate the characteristics of joint disease in HC, aged 18–40 years, compared to age‐matched controls.MethodsThe carrier cohort included females with confirmed HC status. Controls had no personal or family history of bleeding disorders. All females with a history of joint trauma or surgery within 12 months or any history of joint replacement were excluded. Joint health was assessed by clinical history, Haemophilia Joint Health Score (HJHS) and point‐of‐care musculoskeletal ultrasonography (POC‐MSKUS).ResultsThirty HC and 30 controls were enrolled. For HC, the median factor activity level was 52% (range 17%–100%). Carriers, regardless of baseline factor activity levels, reported higher prevalence of chronic joint pain (p < .001) and swelling (p = .002) than controls. Heavy menstrual bleeding, epistaxis, gingival bleeding and easy bruising were also more prevalent in HC (p < .001). Despite HC having a higher median HJHS score (5 vs. 0, p < .001), no differences were observed when using POC‐MSKUS. HC with a body mass index ≥25 mg/m2 reported more haemarthrosis (p = .037).ConclusionsHC are at increased risk of joint‐related symptoms and poorer joint health than age‐matched controls. Dedicated follow‐up to prevent and treat joint disease in HC is imperative. This study is also a call for additional investigation to clarify the association, or lack thereof, between factor activity and joint disease.
Operating room radiation safety measures: Awareness, compliance, and perceived risks among nurses and other healthcare workers
Authors: Shubayr Nasser 
Published: November 2024

AbstractAimThis study evaluates and compares nurses’ and other healthcare workers’ awareness of and compliance with radiation protection measures in operating rooms and their perceived susceptibility to occupational illness due to radiation exposure.BackgroundCompliance with radiation safety measures minimises occupational radiation exposure risks. Understanding the role of perceived susceptibility to occupational illness in motivating compliance and awareness can enhance safety interventions.MethodsUsing a questionnaire‐based cross‐sectional observational design, this study targeted nurses, physicians, and radiologic technologists working in Saudi Arabian operating rooms. The survey measured awareness of and compliance with radiation protection measures and perceived susceptibility to occupational illness. The STROBE checklist was followed to ensure methodological rigour.ResultsNurses demonstrated the lowest awareness and compliance, and the highest perceived susceptibility to occupational illnesses compared to other healthcare professionals. There was a moderate positive correlation between increased awareness of safety measures and compliance, but a weaker correlation between adherence and perceived risk.DiscussionNurses’ compliance and awareness did not align with their risk perceptions, suggesting a cognitive‐behavioural gap in which stronger risk perceptions among nurses do not lead to proactive protective behaviours. This discrepancy may be attributed to the demanding nature of nursing duties, which often overshadow strict adherence to safety protocols.ConclusionThe study identified significant disparities in radiation safety practices, with nurses demonstrating less awareness and compliance but higher risk perceptions than other healthcare professionals. Interventions are needed to bridge the gap between perceived risk and actual safety behaviours.Implications for nursing and health policyRole‐specific training programmes and continuous education are needed to enhance radiation safety practices among nurses. Policies must support these educational efforts, ensuring that nurses can balance patient care responsibilities with radiation protection measures.
Effectiveness of nursing interventions based on lung cancer trajectory: A systematic review and meta‐analysis
Authors: Kim Hye Jin , Lee Myung Kyung 
Published: November 2024

AbstractAim(s)To evaluate the effectiveness of nursing interventions based on the lung cancer trajectory.BackgroundThe transition to the chronic state of lung cancer requires a shift in the management paradigm. Nurses are crucial in managing the health of patients with lung cancer through various services. Therefore, rigorous research is required to understand and provide evidence on the influence of nursing interventions.Sources of evidenceWe systematically selected studies on nursing interventions for patients with lung cancer published from 2000 to 2022 based on specific inclusion and exclusion criteria. A systematic review was conducted according to the Cochrane Handbook and PRIMA 2020 guidelines, and a meta‐analysis was performed. The risk of bias in the included studies was evaluated using ROB 2.0.ResultsIn this study, lung cancer trajectories were classified into diagnosis, treatment, survival, and end‐of‐life care based on a literature review. A meta‐analysis of 47 nursing intervention studies involving 4852 patients confirmed the large effectiveness in significantly improving health‐related quality of life, emotional symptoms, self‐care behaviors, adjustment, satisfaction, health resource use, cost‐effectiveness, and cancer symptoms. Only one study has been conducted on the end‐of‐life trajectory, highlighting the need for more nursing intervention research in this area.ConclusionsRecent nursing experimental studies involving patients with lung cancer show small, large, and medium effect sizes during the diagnosis, treatment, and survival trajectories, respectively.Implications for nursing practice and researchA tailored nursing plan based on the disease trajectory is essential. Stakeholders should consider allocating resources to develop and strengthen nursing interventions, particularly at the diagnostic and end‐of‐life trajectories.
Effectiveness of nursing interventions on patient experiences with health care: A systematic review and meta‐analysis
Authors: Li Yijing , Liu Shanshan , Cai Yan , Cun Wei , Zhang Xue , Jiang Yan 
Published: November 2024

AbstractAimTo synthesize and evaluate the effects of nurse‐led or nursing‐focused interventions for improving patient experience with health care in hospitals.BackgroundPatient experiences have increasingly been highlighted as a key healthcare quality indicator in many countries with highly developed healthcare systems. It is critical to learn about the effectiveness of previously conducted nursing interventions since nursing care is reported to be the primary driver of patient experience.MethodsThis systematic review and meta‐analysis was conducted in accordance with the JBI Manual for Evidence Synthesis and followed the PRISMA statement guidelines. The PubMed, Web of Science, Embase, Cochrane Library, and CINAHL databases were systematically searched in May 2023. Randomized controlled trials and quasi‐experimental studies that were led by nurses or focused on nursing care strategies were included. The JBI critical appraisal checklists were employed to assess methodological quality.ResultsA total of 15 761 records were identified; 11 studies met the inclusion criteria. Nursing interventions focused on optimizing the approach to nursing rounds, enhancing communication with patients, improving patient education, and increasing interaction with patients. The meta‐analysis showed that nursing interventions increased top‐box responses in the communication about medicines and discharge information dimensions, as well as the overall experience dimension, including the overall hospital rating and willingness to recommend the hospital.ConclusionsAlthough few studies were included, this meta‐analysis showed that nursing interventions improved patients’ experiences in communication about medicines and discharge information, as well as their overall experience. More rigorous studies are needed to better understand the effect of nursing interventions and examine which components may be most effective for improved outcomes.Implications for nursing practice and nursing policyOwing to the powerful influence of nursing, strategies to engage nurses are a means of improving patient experiences. More attention should be given to patients’ experiences of communication with doctors and nurses, and more randomized controlled trials are needed to provide high‐quality evidence.
The Pathobiome of Salmo trutta From the North Sea to the Barents Sea
Authors: Lennox Robert J. , Miller Kristina M. , Madhun Abdullah , Schulze Angela D. , Eldøy Sindre Håvarstein , Isaksen Trond E. , Nilsen Rune , Shea Dylan , Birnie‐Gauvin Kim , Davidsen Jan Grimsrud , Cooke Steven J. , Vollset Knut Wiik 
Published: November 2024

ABSTRACTAimSalmonids are some of the best studied species with respect to their pathobiome, and at the northern range limit, there is potential for pathogens to expand with both climate change and increased fish farming in the north.LocationWe sampled sea‐run brown trout from throughout Norway for gill tissue and conducted both pooled and individual screenings for a total of 47 pathogens.Time PeriodSamples were collected during spring in 2020 and 2021.Major TaxaBacteria, viruses and parasites of sea‐run brown trout.MethodsBrown trout were gill biopsied as part of the national sea lice monitoring programme and samples were sent for laboratory analysis using the Fluidigm system, which screened for a broad panel of different pathogenic species.ResultsPermutated multivariate analysis of variance revealed that the pathobiome richness of trout was more related to latitude than to fish farming biomass in the region where samples were taken. However, non‐metric multidimensional scaling revealed a significant association between the individual pathobiome and the number of copepodid‐stage Lepeophtheirus salmonis lice, which did reveal a south/central versus northern Norway segregation in pathogen distributions. Importantly, many pathogens positively associated with sea lice in southern/central Norway are known to be carried, and potentially transmitted by sea lice.Main conclusionsIn northern Norway, pathogens normally associated with infection and disease in trout were more commonly observed. However, given that most pathogens were detected from southern to northern Norway, it appears that further expansion of farms in the north are not likely to lead to further introductions of pathogens into northern areas of Norway, although it could amplify the prevalence of these pathogens on wild salmon.
Adopting Additive Manufacturing in After‐Sales: Developing a Typology of Corrective, Preventive, and Anticipatory Approaches
Authors: Kabelitz‐Bock Robin , Hoberg Kai , Meuer Johannes 
Published: November 2024

ABSTRACTManufacturing firms face complex after‐sales challenges, including spare part shortages. While additive manufacturing (AM) offers a solution by minimizing costs and complexity, not all firms adopt AM equally, and research on differences in AM adoption in the context of spare part shortages is surprisingly scarce. To close this knowledge gap, we apply the awareness‐motivation‐capability (AMC) perspective. Our comparative case study of AM applications in 17 firms identifies three approaches how firms adopt AM—the corrective, preventive, and anticipatory approach. We find that the specific configuration of contextual factors related to a spare part shortage determines the approach firms follow. Using the AMC perspective, we discover and explain why firms differ in adopting AM despite suitable spare part characteristics and similar contexts. Through uniquely analyzing spare part shortages, our study contributes to AM research by challenging the assumption that economic justification is the sole driver of AM adoption and instead revealing that it is a context‐dependent process, with awareness and motivation serving as critical yet underexplored antecedents.
Knowledge, Attitude, and Stigma Among Adolescents: Effect of Mental Health Awareness and Destigmatisation (MHAD) Program
Authors: Manjari Abhirami S. , Sudhesh N. T. 
Published: November 2024

ABSTRACTBackgroundStigma against mental health problems is a common issue for adolescents aged 14–18 years. However, comprehensive programs that simultaneously address awareness and stigma reduction tailored to the specific needs of this age group are lacking.MethodThis study investigated the effectiveness of the Mental Health Awareness and Destigmatisation Program (MHAD) in reducing stigma and improving knowledge and attitudes towards peers with mental health problems. A quasi‐experimental pre‐post design was employed among adolescents aged 14–18 years from an educational institution in Bangalore. After excluding those with high baseline mental health symptoms (PSC‐17 > 20), a preassessment was conducted on adolescents' knowledge, attitude, and stigma (n = 52) using the Mental Health Knowledge Schedule, Self‐structured Case Vignettes, and Peer Mental Health Stigmatization Scale. After completing the 6‐week program, three participants were excluded from the post‐assessment, as their attendance was less than 50%. A total of 49 (mean age = 16 years) adolescents were included in the post‐assessment.ResultsThe paired sample t‐test revealed significant improvements in all stigma scores. The Wilcoxon signed‐rank test indicated a significant improvement in Recognition of Mental Illness scores.ConclusionFindings showed that MHAD, an education‐based program, was effective in reducing adolescents' stigma towards peers with mental health problems and improving their overall recognition of mental health symptoms. Research across larger adolescent populations is essential to enhance these interventions' long‐term impact and sustainability. By closely monitoring and expanding research efforts, we can gain deeper insights into how these programs foster self‐awareness, a crucial factor in recognizing mental health needs, challenging stigma, and promoting help‐seeking behaviors among adolescents.
Nonlesional ileal transcriptome in Crohn's disease reveals alterations in immune response and metabolic pathway
Authors: Lee Ho‐Su , Lee Yoonho , Baek Jiwon , Kim Yongjae , Park Sojung , Jung Seulgi , Lee Jong Geol , Baek In‐Jeoung , Kim Kyuwon , Hwang Sung Wook , Lee Jong Lyul , Park Sang Hyoung , Yang Suk‐Kyun , Han Buhm , Song Kyuyoung , Yoon Yong Sik , Ye Byong Duk 
Published: November 2024

AbstractBackground and AimWe aimed to assess the gene expression profiles of nonlesional small bowels in patients with Crohn's disease (CD) to identify its accompanying molecular alterations.MethodsWe performed RNA sequencing of the uninflamed small bowel tissues obtained from 70 patients with ileal CD and 9 patients with colon cancer (non‐CD controls) during bowel resection. Differentially expressed gene (DEG) analyses were performed using DESeq2. Gene set enrichment, correlation, and cell deconvolution analyses were applied to identify modules and functionally enriched transcriptional signatures of CD.ResultsA comparison of CD patients and non‐CD controls revealed that of the 372 DEGs, 49 protein‐coding genes and 5 long non‐coding RNAs overlapped with the inflammatory bowel disease susceptibility loci. The pathways related to immune and inflammatory reactions were upregulated in CD, while metabolic pathways were downregulated in CD. Compared with non‐CD controls, CD patients had significantly higher proportions of immune cells, including plasma cells (P = 1.15 × 10−4), and a lower proportion of epithelial cells (P = 1.12 × 10−4). Co‐upregulated genes (M14 module) and co‐downregulated genes (M9 module) were identified in CD patients. The M14 module was enriched in immune‐related genes and significantly associated with the responses to anti‐tumor necrosis factor (TNF) therapy. The core signature of the M14 module was comprised of six genes and was upregulated in nonresponders to anti‐TNF therapy of five independent cohorts (n = 163), indicating acceptable discrimination ability (area under the receiver operating characteristic curve of 75–86%).ConclusionsThe differences in gene expression and cellular composition between CD patients and non‐CD controls imply significant molecular alterations, which are associated with the response to anti‐TNF treatment.
Developmental expression patterns of gonadal hormone receptors in arcuate kisspeptin and GABA neurons of the postnatal female mouse
Authors: Watanabe Yugo , Fisher Lorryn , Campbell Rebecca E. , Jasoni Christine L. 
Published: November 2024

AbstractThe arcuate nucleus of the hypothalamus (ARC) is central in the neuronal regulation of fertility and reproduction through translating gonadal steroid hormone cues into the GnRH signaling pathway in the brain. Evidence suggests that circulating gonadal steroids play an important role in modulating female reproduction via kisspeptin and γ‐aminobutyric acid (GABA) neurons in the ARC in both development and adulthood. However, the temporal onset of these ARC neurons' sensitivity to gonadal steroids is unknown. Using RNAscope® in situ hybridization, we localized androgen receptor (Ar), estrogen receptor alpha (Esr1), and progesterone receptor (Pgr) expression in ARC kisspeptin or GABA neurons of female mice at postnatal day (P)4, P8, P12, P20, and P60. A probe that binds to kiss1 mRNA or vGat mRNA was used to produce signal in kisspeptin or GABA neurons, respectively. In adult, we identified that the vast majority of kisspeptin neurons coexpressed Esr1 (95%) and Pgr (93%), while a smaller proportion coexpressed Ar (66%). Similar proportions of Ar‐ or Esr1‐positive kisspeptin neurons were seen from P4, suggesting that kisspeptin neurons develop adult‐like sensitivity to androgen and estrogen in early postnatal life. In contrast, the proportion of Pgr‐positive kisspeptin cells in early life was significantly lower than in adulthood, suggesting that progesterone sensitivity develops over time in the ARC kisspeptin population. ARC GABA neurons also colocalized with Ar (70%), Esr1 (64%), or Pgr (85%) in adulthood. GABA neurons continuously expressed Esr1 or Pgr from the postnatal stages to adulthood, while the proportion of Ar‐positive GABA neurons gradually increased from P4 (24%) to P20 (59%). These results suggest that while ARC GABA neurons can respond to circulating estrogen and progesterone from early postnatal ages, this same population may become more sensitive to androgens during later postnatal life. Our findings identified the expression patterns of Ar, Esr1, and Pgr by ARC kisspeptin and GABA neurons during early postnatal life. These data provide the understanding for the hormone sensitivity of these populations during early postnatal life, the critical time for the formation and regulation of female reproductive physiology. [Correction added on 31 January 2025, after first online publication: Abstract has been updated.]
Assessment of Clients' Perceptions and Satisfaction With Eyebrow Mesotherapy Treatment
Authors: Dobroshi Krenar , Dodov Marija Glavash , Crcarevska Maja Simonovska , Raichki Renata Slaveska , Shuleta‐Qehaja Selvete , Krasniqi Blerim 
Published: November 2024

ABSTRACTBackgroundEyebrows significantly influence facial aesthetics and are often linked to attractiveness and personality. Eyebrow loss and alopecia impact physical and psychological well‐being. Several treatments, including mesotherapy (MT), aim to enhance eyebrow density and quality. Despite the availability of MT for hair growth, its application in eyebrow revitalization is less explored.AimsThis study evaluates clients' perceptions and satisfaction with eyebrow MT (EB MT) using AQ skin solutions' growth factor‐based MT cocktail serum.Patients/MethodsThirty‐two healthy women (ages 21–55) with thin or weakened eyebrows underwent three EB MT sessions spaced 2–4 weeks apart. Exclusion criteria included chronic diseases, allergies, and conditions like pregnancy. Each session lasted about 40 min, and “point by point” and “nappage” techniques were employed. Satisfaction and pain levels were assessed through a Numeric Rating Scale for Satisfaction (NRSS) and Pain scale, while photographic analysis and the Global Aesthetic Improvement Scale (GAIS) evaluated effectiveness.ResultsThe average GAIS score was 8.28, while the NRSS satisfaction score was 8.06. Pain levels were moderately low, averaging 4.0. A high majority (90.6%) were satisfied and willing to continue treatment, with 100% recommending EB MT to others. Notable improvements in overall appearance were reported by participants.ConclusionsEB MT demonstrated high satisfaction and low pain levels, with significant improvements in eyebrow density and appearance. This treatment is a practical option for eyebrow enhancement with a strong safety profile, motivating further clinical application.
Late‐Onset Vitiligo: Epidemiology, Clinical Characteristics, and Management Strategies
Authors: Hasan Zahbi , Pathania Yashdeep Singh 
Published: November 2024

ABSTRACTBackgroundLate‐onset vitiligo (LOV), generally defined as vitiligo that starts at age 30 or older, presents unique diagnostic and management challenges, reflecting an intricate interplay of genetic, environmental, and societal factors.ObjectivesThis review aims to elucidate the distinct aspects of LOV such as epidemiology, clinical characteristics, and treatment outcomes thereby enhancing diagnostic precision and planning management strategies.Materials and MethodsA comprehensive literature search was conducted across multiple databases including PubMed and EMBASE, adhering to PRISMA guidelines. Studies focused on adults (age 30 or older at the time of diagnosis) with LOV were included. Data on demographics, clinical features, and comorbidities were extracted.ResultsThe literature search yielded five eligible articles with a total sample size of 1099 patients. LOV prevalence ranged from 6.5% to 14.7%, with a mean age of onset in the mid to late 50s. Vitiligo vulgaris was the most common form, with increased leukotrichia and the Koebner phenomenon. Associated autoimmune/endocrine disorders, including diabetes mellitus and thyroid diseases, were prevalent, suggesting systemic links. Treatment outcomes varied, with combination therapy and phototherapy showing promise.ConclusionLate‐onset vitiligo differs significantly from early‐onset vitiligo in its clinical traits, epidemiology, and treatment response, necessitating personalized care and targeted management strategies.