bluuebunny/crossref_metadata_2025_split huggingface dataset:
(192) RISK FACTORS FOR ERECTILE DYSFUNCTION IN DIABETES MELLITUS: A SYSTEMATIC REVIEW AND META-ANALYSIS
Authors: Dilixiati D , Waili A , Tuerxunmaimaiti A , Li W , Zebibula A , Rexiati M 
Published: December 2024

Abstract

Introduction
Previous studies have established that diabetes mellitus (DM) markedly raises the risk of developing erectile dysfunction (ED). Despite extensive investigations, the risk factors associated with ED in diabetic men have yet to be unequivocally determined, owing to incongruent and inconclusive results reported in various studies.

Objective
The objective of this systematic review and meta-analysis was to assess the risk factors for ED in men with DM.

Methods
A comprehensive systematic review was conducted, encompassing studies published in the PubMed, Scopus and Embase databases up to August 24th, 2023. All studies examining the risk factors of ED in patients with DM were included in the analysis. To identify significant variations among the risk factors, odds ratios (ORs) and their corresponding 95% confidence intervals (CIs) were employed. The risk of bias was evaluated using the Newcastle-Ottawa Scale for longitudinal studies and the Agency for Healthcare Research and Quality Scale for cross-sectional studies.

Results
A total of 58 studies, encompassing a substantial participant pool of 66 925 individuals diagnosed with DM, both with or without ED, were included in the meta-analysis. Mean age (OR: 1.31, 95% CI = 1.24-1.37), smoking status (OR: 1.32, 95% CI = 1.18-1.47), HbA1C (OR: 1.44, 95% CI = 1.28-1.62), Duration of DM (OR: 1.39, 95% CI = 1.29-1.50), diabetic neuropathy (OR: 3.47, 95% CI = 2.16-5.56), diabetic retinopathy (OR: 3.01, 95% CI = 2.02-4.48), diabetic foot (OR: 3.96, 95% CI = 2.87-5.47), cardiovascular disease (OR: 1.92, 95% CI = 1.71-2.16), hypertension (OR: 1.74, 95% CI = 1.52-2.00), microvascular disease (OR: 2.14, 95% CI = 1.61-2.85), vascular disease (OR: 2.75, 95% CI = 2.35-3.21), nephropathy (OR: 2.67, 95% CI = 2.06-3.46), depression (OR: 1.82, 95% CI = 1.04-3.20), metabolic syndrome (OR: 2.22, 95% CI = 1.98-2.49), and diuretic treatment (OR: 2.42, 95% CI = 1.38-4.22) were associated with an increased risk of ED in men with DM.

Conclusions
Our study indicates that in men with DM, several risk factors for ED have been identified, including mean age, HbA1C, duration of DM, diabetic neuropathy, diabetic retinopathy, diabetic foot, cardiovascular disease, hypertension, microvascular disease, vascular disease, nephropathy, depression, metabolic syndrome, and diuretic treatment. By clarifying the connection between these risk factors and ED, clinicians and scientific experts can intervene and address these risk factors, ultimately reducing the occurrence of ED and improving patient management. Keywords: Diabetes Mellitus, Erectile Dysfunction, Risk factors, Meta-analysis.

Disclosure
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(199) DO PEYRONIE’S DISEASE PATIENTS WITH CONCOMITANT DUPUYTREN’S CONTRACTURES RESPOND BETTER TO INTRALESIONAL INJECTION OF COLLAGENASE CLOSTRIDIUM HISTOLYTICUM?
Authors: Lumbiganon S , Nakamura H , Hammad M , Chawareb EA , Azad B , Lee J , Yafi F 
Published: December 2024

Abstract

Introduction
Dupuytren’s contractures (DC) are prevalent in men with Peyronie’s disease (PD). There is, however, limited data regarding the impact of DC on the efficacy of intralesional injection of Collagenase Clostridium Histolyticum (CCH) for the management of PD.

Objective
This study aimed to examine the demographics of patients undergoing CCH therapy for PD and compare the outcomes between DC and non-DC patients.

Methods
We conducted a retrospective chart review of PD patients attending a tertiary care men’s health center between October 1, 2017 and September 30, 2023. Demographic information, treatment modalities, and outcomes were systematically collected. A comparative analysis was performed between PD patients with and without DC.

Results
Among the 573 patients in this cohort, 43 with history of DC. Two hundred and ninety-two opted for CCH as first line therapy. One hundred eighty-seven patients had at least 4 cycles of treatment. Of those, 17 patients (9.1%) had a history of DC, and 170 (90.9%) did not. Mean ages were 66.7 ± 5.0 (DC) and 57.1 ± 11.3 years (non-DC), P &lt; 0.001 (table 1). The pre-treatment composite degrees of curvature were 47.5 ± 14.4 (DC) and 43.2 ± 13.4 degrees (non-DC), P = 0.210. Number of injection cycles administered were 4.6 ± 0.9 (DC) and 4.6 ± 1.2 (non-DC), P = 0.904. Post-treatment, the composite degree of improvement was significantly higher in the DC group 29.3 + 12.8 degrees, 63.5 + 27.9 % improvement vs 20.8 + 13.9 degrees, 48.1 + 27.9 % improvement in the non-DC group, with a mean difference of 8.6 + 3.7 degrees (95% CI 1.4, 15.8; P = 0.020), and 15.5 + 7.3% improvement (95% CI 1.1, 29.9; P = 0.036).

Conclusions
Our study suggests that the concomitant presence of DC is a predictor of better response to intralesional injection of CCH in men with PD. Despite the limited sample size and the retrospective design, these findings merit further exploration.

Disclosure
Any of the authors act as a consultant, employee or shareholder of an industry for: Endo.
(203) A NOVEL METHOD USING MRI FOR PREOPERATIVE PENILE IMPLANT SIZE PREDICTION: A CASE SERIES
Authors: Nabil M , Ragheb A , Elbatanouny A , Badawy H , Nabil N , Emad M , Youssef M , Elmarakby A , A shaker H 
Published: December 2024

Abstract

Introduction
Penile prosthesis implantation (PPI) is the main treatment for patients with organic factor-related erectile dysfunction (ED) who did not respond to other treatments. Traditionally, diverse intraoperative techniques are used to determine penile implant size.

Objective
This case series aimed to evaluate the efficacy of a novel method for preoperative penile implant size prediction using magnetic resonance imaging (MRI).

Methods
Thirteen Egyptian patients with refractory ED who underwent PPI were examined. Prior to surgery, a biparametric MRI of the penis was performed to measure the length of the right and left corpora cavernosum before and after prostaglandin injection. Then, during surgery, the measurements were repeated to check the accuracy of the preoperative results.

Results
Thirteen patients with mean age of 48.69 ± 10.19 years suffering from refractory ED were included in our series. They underwent implant surgery, five of them with inflatable (infla 10®) implant, four with malleable (tactra®), and four with malleable (rigi 10®). ANOVA test showed that there was statistically significant difference between MRI length measurements before and after prostaglandin injection in the length of both the right (mean = 192.308, VS 154.615, p = 0.011) and left corpora cavernosum (mean = 192.477 VS 164.938, p = 0.001). After prostaglandin injection, ANOVA test showed that there was not a statistically significant difference between MRI length measurement and in operative length measurement in the length of both the right (mean = 192.308, VS 187.769, p = 0.526) and left corpus cavernosum (mean = 192.477, VS 187.769, p = 0.522).

Conclusions
No difference was detected between MRI measurements taken before operation and the measurements taken during the operation of the length of the right and left corpora cavernosum, which shows the ability of MRI to predict the length that can be reached after implantation which could be beneficial in patient’s counselling.

Disclosure
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(204) PSYCHOMETRIC PROPERTIES OF THE COMPULSIVE SEXUAL BEHAVIOR INVENTORY (CBSI-13) BRAZILIAN ADAPTATION
Authors: Finotelli Junior I 
Published: December 2024

Abstract

Introduction
The Compulsive Sexual Behavior Inventory is a scale for use in individuals suffering from problems associated with excessive, impulsive, compulsive, and/or out-of-control sexual behavior. The inventory is recognized for its psychometric capabilities and has cutoff points capable of discriminating individuals with sexual compulsivity issues. Only the 22-item version translated into Brazilian Portuguese was investigated and validated.

Objective
The purpose of this study is to investigate the psychometric characteristics of the 13-item Brazilian-adapted version.

Methods
The data were gathered from archived records of a sexually specialized clinic in Brazil. A total of 225 CSBI-13 applications were identified (cis_male = 142; cis_female = 83; age_mean = 40.11; age_SD = 13.47). Complaints about sexual control concerns were reported by 31% of those surveyed. Confirmatory factor analysis using weighted-least-squares and variance, internal consistency assessment (Cronbach’s alpha coefficient), and t-test were among the analyses performed.

Results
A single-factor model with 13 items was validated, and the fit indices were satisfactory (x2(63) = 39.25; x2/df = .62; CFI = 1.00; TLI = 1.07; RMSEA (90% CI) = .00[.00-.01]; SRMR = .05). Strong internal consistency was estimated. Only the items “felt emotionally distant” and “caused financial problems” had lower factor loadings, whereas the majority loaded &lt;.70. Modification indices suggested proximity between “trouble controlling sexual urges” and “unable to control sexual behavior”, as well “felt guilty or shamed” and “concealed or hidden”. Individuals who reported sexual control concerns scored higher on the total score and eight inventory items.

Conclusions
The findings suggested two evidences of validity for the CSBI-13 Brazilian-adapted version. The 13-item unidimensional model fit the data best, corresponding to the original validation. Score differences showed the instrument’s ability to identify sexual control concerns. The modification items suggested well-known divergences that have been discussed in this field of research.

Disclosure
No.
(206) EXPLORING THE IMPACT OF VARICOCELE ON PROSTATE CANCER PATIENTS: A PROPENSITY-SCORE MATCHED ANALYSIS USING GLOBAL REAL-WORLD DATA
Authors: Hammad MAM , Miller J , Abou Chawareb E , Gryzinski G , Ahlering TE , Yafi FA 
Published: December 2024

Abstract

Introduction
Varicocele is the most common cause of male infertility. Emerging evidence has raised questions about a potential association between infertility and aggressive prostate cancer (PCa).

Objective
Our aim was to investigate whether having a varicocele affects PCa.

Methods
We queried the TriNetX database with access to electronic medical records from 108 partner healthcare organizations worldwide, covering over 129 million patients. We focused on adult males with prostate cancer between 2003 and 2023. Scrotal varices (ICD-10-CM: I86.1) were used to identify varicocele, while prostate cancer patients were identified by ICD-10-CM: C61 codes. We compared the baseline characteristics of PCa patients with and without varicocele, including erectile dysfunction (ED) (ICD-10-CM: N52) and “rising PSA level following PCa treatment” (coded as R97.21). We adjusted for age, BMI, diabetes mellitus, hypertensive diseases, total and free serum/plasma PSA levels, and Gleason score through logistic regression with a 1:1 propensity score matching (PSM). Calculated risk ratios (RR) and Kaplan Meier survival (KM) were calculated after PSM.

Results
Following PSM, 3809 PCa patients were divided into two groups, with an average age of 66.9 +/−10.6 years. Of the varicocele group, 50.97% were coded for “elevated PSA levels”, compared to 33.87% in the non-varicocele group, (p = &lt; 0.001). Additionally, 33.89% of the varicocele group experienced ED, compared to 11.84% in the non-varicocele group, (p = &lt; 0.001). Rising PSA level following PCa treatment was observed in 1.60% of the varicocele group, significantly higher than the non-varicocele group at 0.53%, (p = &lt;0.001). Varicocele patients also exhibited a significantly higher rate of PCa screening, biopsy, and ultrasound-guided needle placement. On KM 5-year survival analysis for ED, patients without varicocele had 78.04% survival probability compared to 70.96% for patients with varicocele, (p = &lt; 0.001).

Conclusions
Our study suggests a potential hypothetical association between varicocele and adverse outcomes in prostate cancer patients, including elevated PSA, ED, and rising PSA after PCa treatment. Further research is warranted to understand the clinical implications of this association and determine the usefulness of varicocelectomy on PCa outcomes.

Disclosure
Any of the authors act as a consultant, employee or shareholder of an industry for: Coloplast, Clarus Therapeutics, Antares Pharma, Acerus.
(209) IT CAN ONLY GET WORSE: AN ANALYSIS OF FACTORS IMPACTING ONLINE PHYSICIAN REVIEWS
Authors: Miller J , Ahmed Z , Gryzinski G , Hammad M , Chawareb E , Yafi F 
Published: December 2024

Abstract

Introduction
Physician review websites offer patients insight to their potential care teams when seeking a new provider. A firm understanding of the factors which patients deem important when assigning these ratings may allow sexual medicine providers an opportunity to improve patient satisfaction.

Objective
To analyze the impact of commonly cited positive and negative qualities of a sexual medicine providers’ practice on online provider ratings.

Methods
Online ratings and reviews through Healthgrade.com and Vitals.com were collected for all physicians listed in the SMSNA Healthcare Provider Directory. Physicians were included if they had received more than 10 ratings and 5 written reviews. The frequency for which specific positive and negative descriptors were included in written reviews was compared to a provider’s average online rating using Wilcoxon-Mann–Whitney tests and non-parametric correlation. Factors which were significantly associated with changes in average ratings were then tested using multiple regression.

Results
Of 331 SMSNA providers, 145 (43.8%) met the inclusion criteria, including 129 male and 16 female providers, receiving an average of 57.0 ratings and 22.6 written reviews each. The average rating was 3.96/5. Factors significantly associated with worsened online ratings included physicians appearing rude or uncaring (-47.0%, p = 0.013), poor clinic staff or nurse quality (-39.2%, p = 0.000), lack of email or phone availability (-37.2%, p = 0.001), poor facilities appearance (-29.5%, p = 0.045), and complications following procedures (-22.7%, p = 0.028). No factors were significantly associated with improved rating scores (Table 1).

Conclusions
Physicians can gain insight to the patient perspective through a careful review of common trends in online physician reviews. On an analysis of reviews for SMSNA providers, multiple factors which remain in the provider’s control, including appearing caring to patients, quality of clinic staff or nurses, and availability by phone or email, appeared to significantly impact online ratings. By focusing on these factors, sexual medicine providers may be able to maintain positive online reviews while offsetting the impact of factors which may remain outside of their control, including the quality of clinic or hospital facilities and complications following procedures. Despite frequent emphasis, wait times and cost of care did not appear to impact overall ratings.

Disclosure
Any of the authors act as a consultant, employee or shareholder of an industry for: Coloplast.
(210) IMPACT OF DIET AND FLUID INTAKE ON ERECTILE FUNCTION: A QUESTIONNAIRE-BASED ANALYSIS
Authors: Abou Chawareb E , Hammad M , Lumbiganon S , Azad B , Yafi N , Osman M , Yafi F 
Published: December 2024

Abstract

Introduction
Erectile Dysfunction (ED), a prevalent and distressing condition affecting men globally, has a multifactorial etiology.

Objective
To investigate the potential role of diet and fluid intake on development and severity of ED.

Methods
Retrospective chart review of a prospectively collected database was performed for patients presenting to our Men’s Health clinic at a single academic institution between July 2018 and March 2020. Demographics, SHIM (Sexual Health Inventory for Men) and ADAM (Androgen Deficiency in Aging Males) questionnaire scores, dietary patterns, fluid consumption habits. Were documented. Patients were categorized into two groups based on their ED status determined by questionnaire scores, and comparisons were made regarding demographics, dietary preferences, and fluid intake.

Results
The study included 618 males, of which 513 (83%) had ED, and 105 (17%) had a normal erectile function. As expected, patients with ED were older, diabetic and hypertensive, p &lt; 0.05. Paleo diet (p 0.030) and organic food consumption (p 0.011) were associated with a lower risk of ED, while consumption of artificial sugary drinks was linked to a higher risk of ED (p 0.036). Other diets such as vegan, vegetarian, gluten-free, keto, low-fat and Mediterranean, as well as quantity of water fluid intake were not associated with ED risks. When accounting for diabetes and hypertension on multivariate analysis, none of the dietary patterns and fluid choices maintained statistical significance.

Conclusions
This study highlights the complex relationship between different factors that contribute to ED. While certain dietary and fluid preferences seemed promising based on initial analysis, their significance diminished when considering the presence of diabetes and hypertension. It is evident that diet plays a role in the development of ED, but further investigation through extensive and prospective studies is needed to gain a deeper understanding.

Disclosure
Any of the authors act as a consultant, employee or shareholder of an industry for: sprout.
(211) TRANSLATION, SEMANTIC EQUIVALENCE, AND CULTURAL ADAPTATION OF THE COMPULSIVE SEXUAL BEHAVIOR DISORDER DIAGNOSTIC INVENTORY (CSBD-DI)
Authors: Finotelli Junior I 
Published: December 2024

Abstract

Introduction
The Compulsive Sexual Behavior Disorder Diagnostic Inventory (CSBD-DI) was developed in response to a novel diagnosis that is both contentious and significant in that it is the first to categorize a disorder associated with excessive, impulsive, compulsive, and/or out-of-control sexual behavior. The scale has versions in four languages and demonstrates good psychometric qualities.

Objective
The study focused on CSBD-DI translation, semantic equivalence, and cultural adaptation to Brazilian Portuguese. Initial step of the Brazilian psychometric study for future studies.

Methods
The scale contains nine items and was developed to measure compulsive sexual behavior disorder (CSBD). The level of measurement of the items ranges from “being true for at least 6 months during the last 12 months” to “never being true of me”. This process was composed of eight professionals qualified for such a method and a convenience sample of 35 participants for the evaluation of intelligibility. The stages were translation, back-translation, assessment of semantic-equivalence, final review by experts, and pre-test version.

Results
Assessing semantic-equivalency showed significant agreement among judges, varying from moderate to strong. This assessment classified the translated items as unaltered or somewhat changed. The expert review met challenges when reaching agreement on descriptions related to sexual practices or behaviors. As indicated in the pre-test version application, incorporating colloquial language descriptions proved critical to the final version’s composition.

Conclusions
The findings indicated a good level of linguistic comprehension. While it was difficult to find proper vocabulary for the general comprehension of excessive, impulsive, compulsive, and/or out-of-control sexual behavior. This version kept the inventory’s name in English but added “Brazilian Adaptation” in Portuguese at the end.

Disclosure
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(214) MULTIPLE GRID INCISION OF TUNICA ALBUGINEA AND SEALING WITH COLLAGEN FLEECE FOR IPP, A PILOT STUDY
Authors: Moon DG , Jo SB , Ahn ST , Park MG , Hwang WK , Kim HJ 
Published: December 2024

Abstract

Introduction
Recently, there have been reports on partial plaque excision and grafting with collagen fleece technique for the treatment of Peyronie’s disease. Previously, the authors reported the modification of this technique as multiple grid incisions of Peyronie’s plaque due to lack of hitological evidence of new tunical regeneration from the collagen fleece graft.

Objective
In this pilot study, we assessed the feasibility of this technique to insert IPP in patients of severe corporal fibrosis from previous failed IPP or Peyronie’s disease with severe deformity.

Methods
From Aug 2018, inflatable IPP (AMS700) was inserted in a total of 9 patients, 4 patients of failed IPP and 5 patients of Peyronie’s disease with severe deformity, respectively. After dissection of the neurovascular bundle or urethra according to the location of plaque or deformity, surgical technique was composed 3 major steps; 1) multiple deep longitudinal tunical incisions over Hegar dilator to achieve enough tunical diameter for insertion of sylinder into the corpus cavernosum and correct bottle neck deformity, 2) multiple transverse incision of tunica to correct penile curvature and gain enough length of corporal body and 3) sealing with collagen fleece (TachoSil®) without suturing. Prospectively, we assessed the stretched penile length (SPL), totally straightness, erectile function were evaluated at 3, 6 and 12 months.

Results
Mean patient age was 61.7 years (range: 56–67). In 5 patients of Peyronie’s disease, mean curvature was 53.5 (40-80) degree and all with hinge and hourglass deformity. Inflatable IPP(AMS 700CX) was inserted in all 5 patients and achieved total straightness after mean operative time of 150 min.. Glans necrosis was occurred in two patients and skin necrosis in 3 but resolved with cell therapy after 3 months. All 5 patients satisfied in GAQ at 1 year. In 4 patients of previous failed IPP, 2 were prothesis infection and prothesis protrusion in 2. Two patients were satisfied with a little short 15 cm sylinder insertion and 2 patients still dissatisfied with short length of penis.

Conclusions
In patients of failed IPP with resultant severe corporal fibrosis or Peyronie’s disease with severe deformity, multiple longitudinal incision to achieve enough diameter and transverse incision to gain the coporal length enable successful insertion of IPP. Postopeartive skin necrosis or glans necrosis were troublesome in patients of diabetes or compressive dressing.

Disclosure
No.