bluuebunny/crossref_metadata_2025_split huggingface dataset:
Potential HIV transmission risk among spouses: marriage intention and expected extramarital male-to-male sex among single men who have sex with men in Hunan, China
Authors: Wu Weizi , Yan Xiaochen , Zhang Xiaoxia , Goldsamt Lloyd , Chi Yuanyuan , Huang Daoping , Li Xianhong 
Published: June 2019

ObjectiveThe HIV epidemic in China is shifting from the high-risk groups of men who have sex with men (MSM), injection drug users and sex workers to the general population, and sexual contact among spouses is assumed to be one route of transmission. Our objective was to determine the intention to marry and the expected extramarital male-to-male sex among single Chinese MSM, in order to estimate the potential HIV transmission risk among MSM living with HIV and their female spouses.MethodsWe conducted a web-based, cross-sectional survey between May 2016 and May 2017. A questionnaire covering sociodemographic characteristics, sexual behaviours, HIV-related and homosexuality-related stigma, marriage intention, and expected extramarital sexual behaviours was completed by 556 single MSM in Hunan, China. Descriptive statistics, χ2test, two-sample t-test and multivariate logistic regression analysis were performed.ResultsCurrently 48.9% of the participants intended to marry a woman in their lifetime, and 91% of them reported that they would continue to have sex with men after getting married. Those who were living with parents (OR=2.26), self-identified as bisexual (OR=2.57), had at least one heterosexual partner in the previous 6 months (OR=0.33) and perceived a higher level of self-homosexual stigma (OR=1.78) had greater intention to marry a woman.ConclusionNearly half of Chinese MSM intend to marry women, which has significantly dropped from the estimated percentage more than 10 years ago for Chinese MSM. However, the expectation of extramarital homosexual behaviours was common in these men. Sexual and gender minority stresses especially from family members, homosexual identity assertiveness and related stigma were the main factors for marriage intention, which should be addressed in future studies and practices.
Chemsex-related drug use and its association with health outcomes in men who have sex with men: a cross-sectional analysis of Antidote clinic service data
Authors: Stevens Oliver , Moncrieff Monty , Gafos Mitzy 
Published: June 2019

PurposeChemsex-related drug use (CDU) is an escalating public health issue among men who have sex with men (MSM), associated with significant physical, biomedical and psychosocial harm. Few interventions exist to help MSM engaging in chemsex and little data exist on which to build. This cross-sectional analysis, using data from Antidote, the UK’s only lesbian, gay, bisexual, and transgender specialist drug service, aims to remedy this paucity of data.MethodsModified Poisson regression was used to assess associations between CDU and a range of health outcomes; CDU+ subanalysis disaggregated MSM by primary chemsex drug of concern; and HIV+ subanalysis investigated whether CDU was associated with self-reported treatment adherence, HIV seroconversion and other HIV-specific issues.FindingsCompared with CDU− MSM, MSM presenting for CDU were more likely to be HIV+, current or previous injectors, to have used postexposure prophylaxis in the last year, and have had ≥6 sexual partners in the last 90 days, though less likely to be hazardous alcohol consumers or to have experienced previous suicidal ideation (all p<0.0005). CDU+ subanalysis revealed health outcome differences—those selecting mephedrone were less likely to be hepatitis C+, HIV+, current or previous injectors, or to have experienced previous suicidal ideation (all p<0.0005), whereas those selecting methamphetamine were more likely (all p<0.0005, except suicidal ideation p=0.009).ImplicationsThis analysis shows MSM presenting for CDU are a heterogeneous high-risk population with unmet health needs. There is a need for standardised chemsex surveillance and for improved intersectorial working between sexual health and drug treatment services. Future research should investigate typological differences between MSM presenting for CDU.Originality/valueTo date, this is the world’s largest analysis of MSM seeking treatment for CDU. Further, the publication of ‘real-world’ service data is a valuable addition to the literature alongside surveys and recruited studies.
The desktop study – an essential element of geoforensic search: homicide and environmental cases (west Belfast, Northern Ireland, UK)
Authors: Ruffell Alastair , Barry Lorraine 
Published: June 2019

Abstract
The desktop study of geology, past land use and recent surveys is essential in planning the search for buried items, as it provides information on ground conditions and may explain anomalies. In the first case study, a geophysical search of waste ground in west Belfast (Northern Ireland) identified two anomalies that on excavation were recovered as human skeletal remains. A desktop study, which included Ordnance Survey maps and memoirs, showed the location to have been next to a Jewish cemetery (1901–20), providing a reason for the human remains to be present. In the second case study, legal action was undertaken because a football ground suffered continual flooding. A desktop study preceded a geophysical survey that showed how the area was a former industrial works, infilled with sand but poorly drained, creating a ‘bowl’ into which urban drainage flowed, causing the flooding. The context of land-use change is an example of how useful such combined geological and historical studies can be (using spatial digital data in a GIS), regardless of the age of an object/area of potential forensic interest. A full desktop study should be carried out prior to any field survey to limit the chances of deploying incorrect search assets and misinterpreting discoveries.
Low-Complexity Scalable Extension of the High-Efficiency Video Coding (SHVC) Encoding System
Authors: Shen Liquan , An Ping , Feng Guorui 
Published: June 2019

The scalable extension of the high-efficiency video coding (SHVC) system adopts a hierarchical quadtree-based coding unit (CU) that is suitable for various texture and motion properties of videos. Currently, the test model of SHVC identifies the optimal CU size by performing an exhaustive quadtree depth-level search, which achieves a high compression efficiency at a heavy cost in terms of the computational complexity. However, many interactive multimedia applications, such as remote monitoring and video surveillance, which are sensitive to time delays, have insufficient computational power for coding high-definition (HD) and ultra-high-definition (UHD) videos. Therefore, it is important, yet challenging, to optimize the SHVC coding procedure and accelerate video coding. In this article, we propose a fast CU quadtree depth-level decision algorithm for inter-frames on enhancement layers that is based on an analysis of inter-layer, spatial, and temporal correlations. When motion/texture properties of coding regions can be identified early, a fast algorithm can be designed for adapting CU depth-level decision procedures to video contents and avoiding unnecessary computations during CU depth-level traversal. The proposed algorithm determines the motion activity level at the treeblock size of the hierarchical quadtree by utilizing motion vectors from its corresponding blocks at the base layer. Based on the motion activity level, neighboring encoded CUs that have larger correlations are preferentially selected to predict the optimal depth level of the current treeblock. Finally, two parameters, namely, the motion activity level and the predicted CU depth level, are used to identify a subset of candidate CU depth levels and adaptively optimize CU depth-level decision processes. The experimental results demonstrate that the proposed scheme can run approximately three times faster than the most recent SHVC reference software, with a negligible loss of compression efficiency. The proposed scheme is efficient for all types of scalable video sequences under various coding conditions and outperforms state-of-the-art fast SHVC and HEVC algorithms. Our scheme is a suitable candidate for interactive HD/UHD video applications that are expected to operate in real-time and power-constrained scenarios.
The Salesman’s Improved Paths through Forests
Authors: Sebő András , Zuylen Anke Van 
Published: June 2019

We give a new, strongly polynomial-time algorithm and improved analysis for the metric
s
-
t
path Traveling Salesman Problem (TSP). It finds a tour of cost less than 1.53 times the optimum of the subtour elimination linear program (LP), while known examples show that 1.5 is a lower bound for the integrality gap.

A key new idea is the deletion of some edges of the spanning trees used in the best-of-many Christofides-Serdyukov-algorithm, which is then accompanied by novel arguments of the analysis: edge-deletion disconnects the trees, and the arising forests are then partly reconnected by “parity correction.” We show that the arising “connectivity correction” can be achieved for a minor extra cost.
On the one hand, this algorithm and analysis extend previous tools such as the best-of-many Christofides-Serdyukov-algorithm. On the other hand, powerful new tools are solicited, such as a flow problem for analyzing the reconnection cost, and the construction of a set of more and more restrictive spanning trees, each of which can still be found by the greedy algorithm. We show that these trees, which are easy to compute, can replace the spanning trees of the best-of-many Christofides-Serdyukov-algorithm.
These new methods lead to improving the integrality ratio and approximation guarantee below 1.53, as was shown in the preliminary, shortened version of this article that appeared in FOCS 2016. The algorithm and analysis have been significantly simplified in the current article, while details and explanations have been added.
Regional pulmonary perfusion patterns in humans are not significantly altered by inspiratory hypercapnia
Authors: Asadi Amran K. , Sá Rui Carlos , Arai Tatsuya J. , Theilmann Rebecca J. , Hopkins Susan R. , Buxton Richard B. , Prisk G. Kim 
Published: June 2019

Pulmonary vascular tone is known to be sensitive to both local alveolar Po2 and Pco2. Although the effects of hypoxia are well studied, the hypercapnic response is relatively less understood. We assessed changes in regional pulmonary blood flow in humans in response to hypercapnia using previously developed MRI techniques. Dynamic measures of blood flow were made in a single slice of the right lung of seven healthy volunteers following a block-stimulus paradigm (baseline, challenge, recovery), with CO2 added to inspired gas during the challenge block to effect a 7-Torr increase in end-tidal CO2. Effects of hypercapnia on blood flow were evaluated based on changes in spatiotemporal variability (fluctuation dispersion, FD) and in regional perfusion patterns in comparison to hypoxic effects previously studied. Hypercapnia increased FD 2.5% from baseline (relative to control), which was not statistically significant ( P = 0.07). Regional perfusion patterns were not significantly changed as a result of increased [Formula: see text] ( P = 0.90). Reanalysis of previously collected data using a similar protocol but with the physiological challenge replaced by decreased [Formula: see text] ([Formula: see text] = 0.125) showed marked flow redistribution ( P = 0.01) with the suggestion of a gravitational pattern, demonstrating hypoxia has the ability to affect regional change with a global stimulus. Taken together, these data indicate that hypercapnia of this magnitude does not lead to appreciable changes in the distribution of pulmonary perfusion, and that this may represent an interesting distinction between the hypoxic and hypercapnic regulatory response. NEW & NOTEWORTHY Although it is well known that the pulmonary circulation responds to local alveolar hypoxia, and that this mechanism may facilitate ventilation-perfusion matching, the relative role of CO2 is not well appreciated. This study demonstrates that an inspiratory hypercapnic stimulus is significantly less effective at inducing changes in pulmonary perfusion patterns than inspiratory hypoxia, suggesting that in these circumstances hypercapnia is not sufficient to induce substantial integrated feedback control of ventilation-perfusion mismatch across the lung.
The Tumor Metabolic Microenvironment: Lessons from Lactate
Authors: García-Cañaveras Juan C. , Chen Li , Rabinowitz Joshua D. 
Published: June 2019

Abstract
The extracellular milieu of tumors is generally assumed to be immunosuppressive due in part to metabolic factors. Here, we review methods for probing the tumor metabolic microenvironment. In parallel, we consider the resulting available evidence, with a focus on lactate, which is the most strongly increased metabolite in bulk tumors. Limited microenvironment concentration measurements suggest depletion of glucose and modest accumulation of lactate (less than 2-fold). Isotope tracer measurements show rapid lactate exchange between the tumor and circulation. Such exchange is catalyzed by MCT transporters, which cotransport lactate and protons (H+). Rapid lactate exchange seems at odds with tumor lactate accumulation. We propose a potential resolution to this paradox. Because of the high pH of tumor cells relative to the microenvironment, H+-coupled transport by MCTs tends to drive lactate from the interstitium into tumor cells. Accordingly, lactate may accumulate preferentially in tumor cells, not the microenvironment. Thus, although they are likely subject to other immunosuppressive metabolic factors, tumor immune cells may not experience a high lactate environment. The lack of clarity regarding microenvironmental lactate highlights the general need for careful metabolite measurements in the tumor extracellular milieu.
Training family to assist with physiotherapy for older people transitioning from hospital to the community: a pilot randomized controlled trial
Authors: Lawler Katherine , Shields Nora , Taylor Nicholas F 
Published: June 2019

Objective: To investigate the safety and effectiveness of augmenting physiotherapy with family-assisted therapy, to inform a future, fully powered trial. Design: Parallel pilot randomized controlled trial. Setting: Transition Care Program. Participants: Thirty-five older adults with multimorbidity, recently hospitalized, with a mean age of 84.1 years (SD = 6.1 years) and mean Modified Barthel Index of 67.8 units (SD = 19.2 units), and 40 family members. Interventions: The control group ( n = 18) received usual physiotherapy care. The experimental group ( n = 17) received usual physiotherapy care and family-assisted therapy from a family member trained by a physiotherapist. Main measures: Primary outcomes were falls-related self-efficacy measured by the Short Falls Efficacy Scale – International and falls during the intervention period. Secondary outcomes included daily steps, EQ-5D-3L (three-level version of the EuroQoL five-dimensional health-related quality of life questionnaire) and ICECAP-O (ICEpop CAPability measure for Older people), Modified Barthel Index and Modified Caregiver Strain Index. Results: There were no between-group differences for falls-related self-efficacy. Relative to the control group, the experimental group was observed to have a reduced risk of falling (relative risk = 0.38, 95% confidence interval (CI) = 0.09–1.60) and a reduced falls rate (incidence rate ratio = 0.22, 95% CI = 0.04–1.20) was of borderline statistical significance. The experimental group walked a mean of 944 daily steps more than the control group (95% CI = 139–1748) and had a significant reduction in activity limitation. There were no between-group differences for quality of life or caregiver strain. Conclusion: Augmenting physiotherapy with family-assisted therapy is feasible for older people transitioning from hospital to the community. A fully powered randomized controlled trial is indicated.
Diffusion tensor imaging of the normal-appearing deep gray matter in primary and secondary progressive multiple sclerosis
Authors: Woitek Ramona , Leutmezer Fritz , Dal-Bianco Assunta , Furtner Julia , Kasprian Gregor , Prayer Daniela , Schöpf Veronika 
Published: June 2019

Background Despite strongly overlapping patterns of clinical and histopathologic findings in primary and secondary progressive multiple sclerosis, differences concerning motor symptoms, central nervous system inflammation, atrophy, and demyelination that cannot be accounted for by lesion load alone remain to be elucidated. Purpose To evaluate the normal-appearing deep gray matter in patients with primary and secondary progressive multiple sclerosis, diffusion tensor imaging was used in this study. Material and Methods In 14 multiple sclerosis patients with primary and secondary progressive multiple sclerosis, axial echo-planar single-shot diffusion tensor imaging sequences with 32 diffusion-encoding directions and axial FLAIR sequences were acquired on a 3T system using an eight-channel SENSE head coil. FLAIR hyperintense multiple sclerosis lesions were outlined semi-automatically and normal-appearing deep gray matter was outlined manually (caudate nucleus, globus pallidus, putamen, thalamus, substantia nigra, and red nucleus). Fractional anisotropy and mean diffusivity values within the normal-appearing deep gray matter for the two groups were compared. Results Interhemispheric differences in mean diffusivity values (but not in fractional anisotropy), were significantly higher in primary progressive multiple sclerosis than in secondary progressive multiple sclerosis for the substantia nigra ( P = 0.04) and the putamen ( P = 0.021). Volumes, mean diffusivity, or fractional anisotropy of the remaining normal-appearing deep gray matter did not differ significantly. Conclusion This study showed a higher interhemispheric difference in the mean diffusivity in the substantia nigra and putamen in patients with primary progressive multiple sclerosis than in those with secondary progressive multiple sclerosis. These changes may represent edema, as well as axonal and myelin loss that can affect the normal-appearing deep gray matter of the two hemispheres differently and may point to differences in the laterality of motor symptoms.
Impact of Tyrosine Kinase Inhibitor Starting Dose on Outcomes in Patients With Non-Small Cell Lung Cancer
Authors: Miao Emily , Seetharamu Nagashree , Sullivan Kevin , Eng Stephen , Lee Chung-Shien 
Published: June 2019

Background: Epidermal growth factor receptor (EGFR) and anaplastic lymphoma kinase (ALK) tyrosine kinase inhibitors (TKIs) can cause intolerable adverse events in patients with non-small cell lung cancer (NSCLC) and may be prescribed at a lower dose. Objective: Our objective was to analyze the starting doses of oral EGFR and ALK TKIs in patients diagnosed with NSCLC at our institution. Methods: We conducted a retrospective chart review with patients on EGFR and ALK TKIs for NSCLC. Patients were categorized into 2 groups: patients initiated on Food and Drug Administration (FDA) standard dose (SD) and patients initiated on a reduced dose (RD). Progression-free survival (PFS), overall survival (OS) and other treatment outcomes were compared between both groups. Results: Ninety patients were included for analysis. The median time-to-progression for the SD group (n = 67) and RD group (n = 23) were 13.4 months (95% confidence interval [CI]:8.9-15.6) and 15.1 months (95%CI: 5.6-21.5), respectively. Median time-to-death was not estimable for OS. The predicted OS probability at approximately 15 months post treatment initiation for the SD group and RD group was 81.8% and 80.5%, respectively. Conclusion: Patients who initiated TKI therapy at a RD did not have different PFS and 15-month survival outcomes than patients who initiated TKI therapy at the FDA SD.
Effect of alcohol consumption on patient-reported outcomes in hip arthroscopy: a matched controlled study with minimum 2-year follow-up
Authors: Lall Ajay C , Secretov Erwin , Battaglia Muriel R , Maldonado David R , Perets Itay , Domb Benjamin G 
Published: June 2019

Introduction: There is a paucity of literature examining the effects of alcohol consumption on patient-reported outcomes (PROs) after hip arthroscopy. The purpose of this study was to report 2-year outcomes of hip arthroscopy in patients who consume alcohol compared to patients who abstain. Methods: Registry data were prospectively collected and retrospectively reviewed to identify heavy drinkers at the time of primary hip arthroscopy. Patients were matched 1:1 (heavy drinkers:non-drinkers) based on age, sex, BMI, acetabular Outerbridge grade, and capsular treatment. All patients were assessed with 4 validated PROs: mHHS, NAHS, HOS-SSS, and iHOT-12. Pain was estimated with VAS. Results: 42 patients were pair matched in each group (heavy drinkers:non-drinkers). Both groups demonstrated significant improvement for all PROs and VAS. Heavy drinkers reported lesser improvement in HOS-SSS ( p = 0.0169), smaller decrease in VAS ( p = 0.0157), and lower final scores on iHOT-12 ( p = 0.0302), SF-12 mental ( p = 0.0086), and VR-12 mental ( p = 0.0151). Significantly fewer patients in the heavy-drinking group reached PASS for mHHS ( p = 0.0464). Odds of achieving PASS for mHHS was 2.5 times higher for patients who abstain from alcohol. The rates of revision hip arthroscopy and conversion to total hip arthroplasty were not statistically different between groups. Conclusion: While hip arthroscopy may still yield clinical benefit in drinkers, patients who consume heavy amounts of alcohol may ultimately achieve an inferior functional status and should be counselled on drinking cessation to optimise their results.
Human-induced pluripotent stem cell-derived cardiomyocytes have limited IKs for repolarization reserve as revealed by specific KCNQ1/KCNE1 blocker
Authors: Zeng Haoyu , Wang Jixin , Clouse Holly , Lagrutta Armando , Sannajust Frederick 
Published: June 2019

Objective We investigated if there is IKs, and if there is repolarization reserve by IKs in human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs). Design We used a specific KCNQ1/KCNE1 channel blocker, L-000768673, with an IC50 of 9 nM, and four hERG-specific blockers, astemizole, cisapride, dofetilide, and E-4031 to investigate the issue. Results L-000768673 concentration-dependently prolonged feature point duration (FPD)―a surrogate signal of action potential duration―from 1 to 30 nM without pacing or paced at 1.2 Hz, resulting from IKs blockade in hiPSC-CMs. At higher concentrations, the effect of L-000768673 on IKs was mitigated by its effect on ICa-L, resulting in shortened FPD, reduced impedance amplitude, and increased beating rate at 1 µM and above, recapitulating the self-limiting properties of L-000768673 on action potentials. All four hERG-specific blockers prolonged FPD as expected. Co-application of L-000768673 at sub-threshold (0.1 and 0.3 nM) and threshold (1 nM) concentrations failed to synergistically enhance the effects of hERG blockers on FPD prolongation, rather it showed additive effects, inconsistent with the repolarization reserve role of IKs in mature human myocytes that enhanced IKr response, implying a difference between hiPSC-CMs used in this study and mature human cardiomyocytes. Conclusion There was IKs current in hiPSC-CMs, and blockade of IKs current caused prolongation of action potential of hiPSC-CMs. However, we could not demonstrate any synergistic effects on action potential duration prolongation of hiPSC-CMs by blocking hERG current and IKs current simultaneously, implying little or no repolarization reserve by IKs current in hiPSC-CMs used in this study.