bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficacy and Safety of Sotagliflozin in Patients with Type 1 Diabetes and CKD
Authors: Sridhar Vikas S. , Odutayo Ayodele , Garg Satish , Danne Thomas , Doria Alessandro , Mauer Michael , Davies Michael J. , Banks Phillip , Girard Manon , Cherney David Z.I. 
Published: November 2024

Key Points

Poor glycemic control in type 1 diabetes and CKD is associated with a higher risk of CKD progression.In a subgroup of inTandem participants with type 1 diabetes and CKD, adding sotagliflozin to insulin reduced HbA1c, body weight, and systolic BP without increasing severe hypoglycemia, compared with adding placebo.In participants with type 1 diabetes and CKD, sotagliflozin did not significantly increase the risk of DKA, however, there were a small number of diabetic ketoacidosis events.

Background
This analysis evaluated the efficacy and safety of sotagliflozin, a dual sodium-glucose cotransporter 1 and 2 inhibitor, added to insulin in patients with type 1 diabetes and CKD.

Methods
We used data from the 52-week pooled inTandem 1 and 2 trials and the 24-week inTandem 3 trial to assess the effects of sotagliflozin (200 mg [inTandem 1 and 2 only] or 400 mg daily) versus placebo on glycated hemoglobin (HbA1c; primary end point), body weight, systolic BP, insulin dose, and safety end points including adjudicated severe hypoglycemia and diabetic ketoacidosis (DKA), stratified by CKD.

Results
CKD was identified in 237/1575 inTandem 1 and 2 participants and 228/1402 inTandem 3 participants. At week 24, significant, placebo-adjusted reductions in HbA1c were observed—inTandem 1 and 2: non-CKD subgroup (sotagliflozin 200 mg: −0.4%, 95% confidence interval [CI], −0.4 to −0.3; 400 mg: −0.4%, 95% CI, −0.5 to −0.3) and CKD subgroup (sotagliflozin 200 mg: −0.4%, 95% CI, −0.6 to −0.1; 400 mg: −0.3%, 95% CI, −0.5 to −0.1). For systolic BP, there was a significant reduction at week 24 with sotagliflozin in the non-CKD subgroup, but no effect in the CKD subgroup in inTandem 1 and 2. At week 52, the incidence of severe hypoglycemia was lower with sotagliflozin (7% on 200 mg and 4% on 400 mg) compared with placebo (17%) in the CKD subgroup of inTandem 1 and 2, whereas the incidence of severe hypoglycemia was 5%–6% across non-CKD subgroups. The incidence of adjudicated DKA at week 52 was 1%, 5%, and 3% for placebo, 200, and 400 mg in the CKD subgroup compared with 0%, 3%, and 4% in the non-CKD subgroup, respectively. The results were generally similar in inTandem 3, except systolic BP was significantly reduced with sotagliflozin versus placebo in CKD and non-CKD subgroups.

Conclusions
In participants with type 1 diabetes and CKD, sotagliflozin treatment had similar HbA1c, body weight, and systolic BP lowering effects as in participants with type 1 diabetes without CKD. In addition, sotagliflozin was associated with a lower to neutral risk of severe hypoglycemia and did not significantly increase the risk of DKA among a small number of DKA events.

Clinical Trial registration numbers:

NCT02384941, NCT02421510, NCT02531035.
Phytochemical Content towards Weak Antioxidants Activity of Traditional Fermented VCO as the Basic Ingredient for Ear Drops
Authors: Suryani Suryani , Arief Syukri , Suryati Suryati , Dafriani Putri , Agustin Diana , Putra Adewirli , Mardhatillah Mardhatillah , Ramadani Silmi Yusri , Sariani Sariani 
Published: November 2024

Chronic Suppurative Media Otitis is caused by pathogenic bacteria, which, if the growth is not controlled, will cause meningitis and can lead to death. Virgin Coconut Oil is an oil made through the traditional fermentation process of coconut milk and can inhibit the growth of pathogenic bacteria that cause Chronic Suppurative Media Otitis. So far, pathogenic bacteria can be controlled using ear drops made from artificial chemicals, which can cause resistance. Only a few have studied the manufacture of natural-based ear drops from VCO. The purpose of this study is to study the potential of VCO as a natural essential ingredient for ear drops for patients with OMSK by analyzing its antioxidant content using the DPPH method and its phytochemical content using Ultraviolet-Visible Spectroscopy (UV-Vis) and Gas Chromatography-Mass Spectrometry (GC-MS). Its antioxidants in the IC50 (ppm) region are 583.92mg/L. The types of fatty acids contained in VCO consist of Medium-Chain Fatty Acid (MCFA), Long-Chain Fatty Acid (LCFA) and Very Long Chain Fatty Acid (VLCFA), the most of which is lauric acid (MCFA), as much as 49.28%. Conventional analysis of secondary metabolites showed the presence of Alkaloids, Terpenoids, Ascorbic Acid, and Saponins. It can be concluded that the chemical content of Virgin Coconut Oil made from fermentation can be used in the health field as a primary ingredient for making ear drops for CSOM patients.
Percepciones Sobre la Evaluación en Línea del Aprendizaje Universitario
Authors: Araneda Daniel Serey , Fiallos Peña Blanca Inés , González Consuelo Arce , Burgos Jorge Balladares 
Published: November 2024

En el ámbito universitario la pandemia instalo como parte de la oferta académica el formato de clases online, como una manera de mejorar la cobertura en el posgrado. El objetivo de este estudio es examinar las percepciones de los docentes de posgrado en educación sobre los procesos de evaluación del aprendizaje universitario de programas en línea. El presente estudio adopta un enfoque cuantitativo, no experimental y de corte transversal, utilizando estadísticas y cuantificando aspectos observables. La muestra consistió en 125 docentes de posgrado en educación, a quienes se les administró un cuestionario diseñado ad hoc, que contó con índices adecuados de validez y confiabilidad. Los resultados indican que evaluar en formato online es particularmente desafiante. Al indagar sobre el impacto emocional en la evaluación, se percibe una variación de los niveles de ansiedad de los docentes de una universidad a otra. La evaluación en línea presenta desafíos según los docentes encuestados, quienes informan que tienen dificultades para evaluar la parte práctica, controlar las actividades de los estudiantes y atender consultas durante la prueba de evaluación. Además, los docentes experimentan más ansiedad al aumentar las horas en línea para atender a los alumnos.

At the university level, the pandemic installed the online class format as part of the academic offer, as a way to improve postgraduate coverage.The objective of this study is to examine the perceptions of graduate educators in the field of education regarding the assessment processes of online university learning programs. Method. The present study adopts a quantitative, non-experimental, cross-sectional approach, using statistics and quantifying observable aspects. The sample consisted of 125 graduate educators in education, who were administered a specifically designed questionnaire with appropriate indices of validity and reliability. The results indicate that evaluating in an online format is particularly challenging. When investigating the emotional impact on assessment, variations in anxiety levels among educators from one university to another are perceived. Conclusions. Online assessment poses challenges according to the surveyed educators, who report difficulties in evaluating the practical component, controlling student activities, and addressing inquiries during the assessment test. Additionally, educators experience increased anxiety as online hours for student support increase.
Lamiaceae Family Plants as Natural Solutions for Inflammation and Blood Sugar Management
Authors: Lagouri Vasiliki , Tebbi Sara Oumenoune , Caseiro Armando , Trapali Maria 
Published: November 2024

The Lamiaceae family, including common herbs like rosemary and mint, is being investigated for its potential health benefits. In addition to numerous health benefits, research is looking into these plants' anti-inflammatory qualities and potential impacts on blood sugar regulation. More specifically, the Greek endemic Lamiaceae plants are proven to be of great importance, regarding their bioactive compounds and the antioxidant, antidiabetic and anti-inflammatory properties they have. The study's objective was to compile information from the literature regarding the anti-inflammatory, antidiabetic, and antioxidant properties of Origanum rotundifolium, Rosmarinus officinalis, Lavendula angustifolia, and Thymus serpyllum. Lavender angustifolia is used for many traditional medical and cosmetic products. Several studies demonstrated strong anti-inflammatory mechanisms exhibited by Rosmarinus officinalis. Leukocyte migration was found to be significantly inhibited in vivo by rosemary essential oil and extract. Changes in the gut microbiota induced by essential oils rosemary as prebiotics in mice regulated cardiovascular and metabolic factors, which focus on the potential of these nutraceuticals for reducing Ischemic heart disease risk in patients affected by type-2 diabetes mellitus. A mixture of Origanum majorana and Origanum vulgare plants investigated antidiabetic activities in zebrafish. The Lamiaceae family provides a natural source of substances that may be used in functional foods. These functional meals have the potential to improve general health and help manage chronic illnesses. The precise mechanisms of action of these plants and the best doses for use in functional food applications require more investigation.
Artistic Visualization Of Senja Dengan Dua Kelelawar Script By Kirdjomulyo Through Herry Dim's Art Creation Method
Authors: Purnomo Heny , Hari pramono Koko , Indar Moslem Mochamad Danuar 
Published: November 2024

The stage serves as a barrier between the artists and the audience, therefore theatrical activities are inextricably linked to it. In order for a theatrical performance to flow smoothly and for the audience to engage with the performers, the stage is a crucial component. Through artistic communication, aesthetic value is created. In the end, this serves as the foundation for artistic endeavours involving the visualization of artistic arrangements on stage. In order for the artistic arrangement in a performance to become more than just a connected component and instead become a whole theatrical production, the director and artistic director must also be able to give meaning to the various elements. Through the visual medium of performing arts, the audience can be given aesthetic gratification through the implementation of a comprehensive creative arrangement. In addition to using Herry Dim's method of art creation, this piece employs a representational theatre style performance approach with accurate and naturalistic environmental descriptions. The artistic arrangement of the script "Senja degan Dua Kelelawar" is another goal in the development of this piece of theatre art. The developed concept was then utilized to visualize the artistic layout of the script Senja degan Dua Kelelawar" and create works of art by combining different parts and elements of the artistic layout that ultimately resulted in a performance. Hence, it can deliver a visually stunning and harmonic performance on stage
Guia de revisão de metadados
Authors: Santos Gildenir Carolino 
Published: November 2024

Este guia tem como objetivo possibilitar a organização e revisão dos metadados disponibilizados nos artigos dos periódicos gerenciados tanto no Portal de Periódicos Eletrônicos Científicos, quanto no Portal da Incubadora de Periódicos Acadêmicos. Os metadados são informações adicionadas a um dado principal (ou seja, em outras palavras, é um “dado novo sobre um dado” e, por isso, o seu nome).Trata-se de um conjunto de elementos que possuem uma semântica padronizada, possibilitando descrever as informações eletrônicas ou recursos eletrônicos de maneira bibliográfica. Os metadados são extremamente importantes para a identificação, a organização e a recuperação da informação digital. Facilitam a localização e recuperação das informações eletrônicas. Utilizando-se dos procedimentos de representação, indexação e classificação dos conteúdos, possibilitando a integração de fontes diversificadas e heterogêneas de informação.
Quail Carcass Performance Using Additional Feed Combination Of Noni Leaf Flour And Black Cumin Flour
Authors: Nur Khaeriyah , Abdullahi Alima Bachtiar 
Published: November 2024

Background: Digestive disorders can attack quail and will have an impact on reducing their productivity, such as live weight, abdominal fat weight, and decreased carcass performance. Purpose: Providing additional feed from herbal plants in the form of noni flour and black cumin flour can overcome digestive system problems because they contain active substances that are useful as feed supplements, anti-inflammatory, anti-bacterial and others for the livestock's body. Method: The research design was a completely randomized design (CRD) with 4 treatments and 4 replications, each replication consisting of 6 quail. Feed treatments were P0: commercial feed (control), P1 = commercial feed + 1% black cumin flour + 3% noni leaf meal, P2 = commercial feed + 2% black cumin flour + 2% noni leaf meal, P3 = commercial feed + black cumin flour 3% + noni leaf flour 1%. The data was then analyzed using analysis of variance (ANOVA). Results: The results showed that the treatment given had a significant effect on the percentage of quail carcass weight. The P3 treatment was significantly higher than the other treatments, whereas the P2 treatment was the lowest compared to the other treatments, while the P0 and P1 treatments were not significantly different. Other parameters did not have a significant effect on the percentage of quail abdominal fat, pH, percentage of water holding capacity, and percentage of cooking loss of quail meat. Conclusion: In conclusion, the treatment had a significant effect on the percentage of quail carcass weight, while it had no significant effect on the percentage of quail abdominal fat, pH, percentage of water holding capacity, and percentage of cooking loss of quail meat.
Evaluation of Feed Additive Nutmeg Seed Powder (Myristica fragnans Houtt) on Egg Quality Characteristics and Egg Production
Authors: Leke Rinny , Wantasen Erwin , Sompie Florencia , Kiroh Hengky , Kumajas Nontje , Laihad Jacquline , Kaunang Charles , Siahaan Ratna 
Published: November 2024

Background: Poultry production faces food safety issues. Increasing public awareness of the risk of developing pathogen cross-resistance to antibiotics has resulted in the gradual elimination of antibiotics for therapeutic purposes. Transitioning from antibiotic supplementation to adoption of effective alternative control methods. Prohibition of the use of antibiotics in the feed of laying hens increase the usage of natural antibiotics from plants. The addition of feed additive nutmeg seed powder as helps the body to fight stress with anti-oxidative properties, improves immune function and restores normal physiology. The addition of polyphenols, withanolides, vitamins, minerals and other herbal products in the feed has shown considerable improvement in health in poultry. Purpose: This study aims to study the evaluation of feed additive nutmeg (Myristica fragrans Houtt) seed powder on egg quality characteristics and egg production. Method: A number of 200 chickens were used with 5 treatments and 5 replications and each repetition was occupied by 8 laying hens. The treatment given was R0 = 100% Basal Feed/BF (without nutmeg flour), R1 = 0.5% Nutmeg Seed Powder (NSP) + 99.5% BF, R2 = 1% NSP + 99% BF, R3= 1.5% NSP+ 98.5% BF, R4 = 2% NSP+ 98% BF. Results: The results of the study were egg weight, Haugh Unit, egg mass, shell index, egg shell thickness, yolk index, yolk color, egg yolk protein, egg white protein, egg yellow fat, cholesterol which gave very significantly different results (p<0.01). Feed Consumption (g/bird), HDP (%), Conversion (p>0,05). Conclusion: The feeding up to 2% of nutmeg seed powder given to laying hens can improve the egg quality characteristics and egg production.
Reproductive Performances of SIMGOUD Crossbreed Cows and The Effect of Concentrate Feed Supplementation on The Production and Chemical Composition of Milk
Authors: Mouchili Mama , Pouachiyouen Pechangou Edouard Aimé , Miegoué Emile , Lemoufouet Jules , Tendonkeng Fernand 
Published: November 2024

Background: The performance of milk production remains very weak. This low performance is mainly explained by the low genetic potential of local breeds (1 to 3 litre of milk/day or even less in the dry season compared to 40 to 50 l/day for Holstein cows in Europe). Purpose: The present study on the evaluation of the reproductive performance of Simgoud crossbreed cows and the effect of feeding on the production and chemical composition of milk was conducted at the SODEPA ranch of Faro in Adamaoua Cameroon between July and August 2023. Method: The Simgoud cow is a cross between the exotic Simmental and the local Goudali breeds. The animals were divided into two batches of six cows and six calves per batch, of comparable physiological condition. Results: The age at first calving was 39 months, and the crossbreeding allowed the farmer to decrease the age at first calving of the Goudali by 24%. The observed calving interval was 18 months with a variation rate of 16.20%. The total amount of milk produced in 90 days by the cows that received a feed supplement (concentrate) was estimated at 810 liters for an average daily production of 9.66 liters, compared to 666 liters over the same lactation period in the cows that did not receive a supplement, an average of 7.46 liters per day. Supplementation had a significant effect on milk production. The analysis of the chemical composition of the milk shows that apart from the pH, the supplementation of Simgoud cows with concentrate had a significant effect, improving the content of all other parameters studied. Conclusion: Supplementation is recommended for the improvement of the milk production parameters in Simgoud cows.
Detection of Toxoplasma gondii Infection in Rodents, Shrews and Cats in Unguja Island, Zanzibar
Authors: Paul Cynthia M. , Ally Ally A. , Mkupasi Ernatus M. , Martin Martin J. , Katakweba Abdul A.S. 
Published: November 2024

Background: Toxoplasma gondii is an intracellular protozoan parasite that causes a zoonotic infection known as toxoplasmosis. Felid vertebrates including cats serve as the definitive hosts of T. gondii and rodents and shrews are among the common intermediate and reservoir hosts. Little is known about the infection in both humans and animals despite the high interaction between humans and cats on the island. Purpose: This study aimed at determining the prevalence of T. gondii infection in rodents, shrews and cats in Unguja Island, Zanzibar. Method: The study employed a cross-sectional design. A total of 366 small mammals (230 rodents, 43 shrews and 93 cats) were captured and blood was sampled from the seven districts of Unguja Island. Serum samples were subjected to the Indirect ELISA technique with the aid of the ID Screen® Toxoplasmosis Indirect Multi-species Kit to look for antibodies directed against T. gondii. Results: Seropositive samples were detected from one rodent species (Rattus rattus) and one shrew species (Crocidura spp.) among the six different rodent and shrew species captured. Fifty-one seropositive samples from cats were detected where eight were from pet cats and 43 from stray cats. In rodents, no significant variation was found according to species, sex and habitat (p≥0.05) but in cats, there was a significant variation between habitats (p≤0.05). Conclusion: The study revealed the exposure status of rodents, shrews and both stray and pet cats in Unguja Island, thereby revealing the potential risk of the infection transmission to humans due to close proximity with these animals, especially cats as pets. Emphasis should be made through public health education programs about the transmission of the infection and the control measures needed to mitigate the risks.
Prevalence of Gastrointestinal Endoparasites in Free-Range Chicken at Traditional Market Payakumbuh
Authors: Ilahi Yusra , Zelpina Engki , Putri Ii Amelia , Sujatmiko  , Amir Yurni Sari , Suliha  
Published: November 2024

Background: Worm infections in free-range chickens are an important health issue in the animal food industry and consumption in Indonesia. Purpose: This study aims to determine the prevalence of worms in the intestines of free-range chickens sold in traditional markets in Payakumbuh City, and to identify their types. Method: Worm identification was carried out using samples of chicken intestines from traditional markets in Payakumbuh City. The samples were taken to the laboratory to be dissected to check for the presence of worms in the intestines. Intestines that were positive for worms were placed in a petri dish containing distilled water before being placed in a plastic bottle containing 70% ethanol. The method used for staining was Acetocarmine Semichon for cestodes and clove oil for nematodes. Worm species was determined by observation under a microscope. Data in the form of the types of worms found was analyzed descriptively. Data obtained quantitatively, namely the prevalence of endoparasites, was processed using Ms. Excel 2013. Results: The results showed that 31 out of 50 samples of free-range chicken intestines (Gallus domesticus) examined in traditional markets in Payakumbuh City were positive for worm infections. The prevalence of worm infections in traditional markets in Payakumbuh City was found to be 62%. The prevalence based on the type of endoparasite in traditional markets in Payakumbuh City was Railletina sp. (28%), Hymenolepis sp. (6%), Ascaridia sp. (14%), and Hetarakis sp. (14%). Conclusion: The prevalence rate of worm infections in free-range chickens in traditional markets in Payakumbuh City was 62%. The types of worms found were Railletina sp., Ascaridia sp., Hetarakis sp., and Hymenolepis sp. The most common type of worm was Railletina sp.
Describing the Level of Awareness of Micro-Enterprises in Local Taxation
Authors: Rivera Paul Cezam , Mirrar Allene Kyle , Malazarte Mark Nicole 
Published: November 2024

Background: Local taxes play a vital role in contributing significant socio-economic development and welfare in the city. This paper describes the level of awareness of micro-enterprises in local taxation.
Objective: This study wants to comprehensively describe and conduct a detailed analysis of the level of awareness among micro-enterprises regarding local taxation in Pagadian City, how such awareness helped these owners manage their business operations, and where they stay informed about local tax ordinances.
Method: This research employed a mixed-methods sequential explanatory design using a survey questionnaire. Then, the weighted mean and standard deviation, with the help of SPSS, were used to analyze the quantitative part of the research. It drew inspiration from Sharan Merriam's work, which emphasized the importance of patterns and themes.
Results: This study revealed that micro-enterprise owners exhibit a high level of awareness regarding business taxes but need more awareness of amusement taxes. Awareness helped the owners in their business operations in the following ways: avoid penalties, smooth business operation, good decision-making, proper management, improvement skills, lessening tax stress, good reputation, successful business, business improvements, understanding customers, and properly registered. Additionally, the Bureau of Internal Revenue (BIR) emerged as the predominant source of knowledge concerning local tax ordinances.
Conclusion: In Pagadian City, most micro-business owners understand local taxes. They know about Business Tax, which applies to all businesses, regardless of size. However, they must learn about amusement taxes due to the complex Philippine tax system.

Keywords: local tax ordinances, tax awareness, Philippine taxation, micro-enterprises, taxation