bluuebunny/crossref_metadata_2025_split huggingface dataset:
HLA and Complement Typing in Olivo-ponto-cerebellar Atrophy
Authors: Wastiaux J. P. , Lamoureux G. , Bouchard J. P. , Durivage A. , Barbeau C. , Barbeau A. 
Published: May 2019

SUMMARY:HLA antigen typing was carried out in a family with an autosomal dominant form of spinocerebellar degeneration [possibly olivoponto cerebellar atrophy (O.P.C.A.) — Type 1] . Eleven ataxic patients, three possibly ataxic subjects, two unrelated spouses and 13 clinically normal at risk siblings were typed for ABO and Rh blood groups, HLA-A and HLA-B antigens, C4 component of the complement and a number of other serum proteins (Clq, (β -1A, (β-1C, C5, (β -lipoproteins). No solid evidence for linkage between the ataxia gene and the HLA or C4 loci could be demonstrated in this family. Certain serum proteins, and particularly β -lipoproteins were found to be significantly reduced in some sub-groups of subjects.
Lipoamide Dehydrogenase in Friedreich's Ataxia Fibroblasts
Authors: Melançon S. B. , Potier M. , Dallaire L. , Fontaine G. , Grenier B. , Lemieux B. , Geoffroy G. , Barbeau A. 
Published: May 2019

SUMMARY:Lipoamide dehydrogenase was measued in cultivated skin fibroblasts from twelve patients with Friedreich's ataxia and nine normal controls. No difference in specific activity, subcellular distribution and Vmax or Km was observed between patients and controls.
Cerebellar Ataxia Produced by 3-Acetyl Pyridine in Rat
Authors: Butterworth R. F. , Hamel E. , Landreville F. , Barbeau A. 
Published: May 2019

SUMMARY:A single intraperitoneal injection of 3-acetyl pyridine produces, within 24 hours of administration, signs of cerebellar ataxia and damage to the medulla oblongata and to the climbing fibers of the cerebellum. These changes are accompanied by changes in the concentration of certain amino acids in the appropriate areas. Glutamic acid is decreased in cerebellum, medulla, cortex, striatum, hippocampus, retina and olfactory bulbs, while taurine is specifically decreased in the cerebellum and medulla oblongata and aspartic acid in the retina. The concentrations of GABA and glycine are not modified in any of the areas studied. Glutamine is generally increased in concentration in areas of cell damage.
Antagonism by Taurine of Morphine Induced Growth Hormone Secretion
Authors: Collu R. , Charpenet G. , Clermont M. J. 
Published: May 2019

SUMMARY:The intraperitoneal (IP) or intraventricular (IVT) administration of small amounts of taurine did not modify pentobarbital-induced sleep or pituitary hormone release. However, the drastic increment in plasma GH values induced by morphine administration was completely blocked by the IVT injection of the amino acid. Whether taurine plays a physiological role in the control ofGH secretion is highly speculative.
Early socioemotional competence, psychopathology, and latent class profiles of reparative prosocial behaviors from preschool through early adolescence
Authors: Donohue Meghan Rose , Tillman Rebecca , Luby Joan 
Published: May 2019

AbstractChildren who have difficulty using reparative behaviors following transgressions display a wide range of poorer social and emotional outcomes. Despite the importance of reparative skills, no study has charted the developmental trajectory of these behaviors or pinpointed predictors of poorer reparative abilities. To address these gaps in the literature, this study applied growth mixture modeling to parent reports of children's reparative behaviors (N = 230) in a 9-year longitudinal data set spanning from preschool to early adolescence. Three distinct trajectories of reparative behaviors were found: a low-stable, moderate-stable, and high-stable latent class. Poorer emotion understanding, social withdrawal, social rejection, and maladaptive guilt in the preschool period predicted membership in a low-stable reparative trajectory. Externalizing diagnoses, particularly conduct disorder and oppositional defiant disorder, also predicted membership in a low-stable reparative trajectory. Preschool-onset depression predicted membership in a low-stable reparative trajectory through high levels of maladaptive guilt. The findings from this study suggest that socioemotional deficits in the preschool period set children on longstanding trajectories of impaired reparative responding. Thus, emotion understanding, social functioning, maladaptive guilt, and early psychiatric symptoms should be targeted in early preventive interventions.
Singular value automata and approximate minimization
Authors: Balle Borja , Panangaden Prakash , Precup Doina 
Published: May 2019

AbstractThe present paper uses spectral theory of linear operators to construct approximatelyminimal realizations of weighted languages. Our new contributions are: (i) a new algorithm for the singular value decomposition (SVD) decomposition of finite-rank infinite Hankel matrices based on their representation in terms of weighted automata, (ii) a new canonical form for weighted automata arising from the SVD of its corresponding Hankelmatrix, and (iii) an algorithmto construct approximateminimizations of given weighted automata by truncating the canonical form.We give bounds on the quality of our approximation.
Cerebrospinal fluid biomarkers in patients with central nervous system infections: a retrospective study
Authors: Di Stefano Alessandro , Alcantarini Chiara , Atzori Cristiana , Lipani Filippo , Imperiale Daniele , Burdino Elisa , Audagnotto Sabrina , Mighetto Lorenzo , Milia Maria Grazia , Di Perri Giovanni , Calcagno Andrea 
Published: May 2019

BackgroundCentral nervous system (CNS) may be infected by several agents, resulting in different presentations and outcomes. Analysis of cerebrospinal fluid (CSF) markers could be helpful to differentiate specific conditions and setting an appropriate therapy.MethodsPatients presenting with signs and symptoms were enrolled if, before receiving a diagnostic lumbar puncture, signed a written informed consent. We analyzed CSF indexes of blood–brain barrier permeability (CSF to serum albumin ratio or CSAR), inflammation (CSF to serum IgG ratio, neopterin), amyloid deposition (1–42 β-amyloid), neuronal damage (Total tau (T-tau), Phosphorylated tau (P-tau), and 14.3.3 protein) and astrocyte damage (S-100β).ResultsTwo hundred and eighty-one patients were included: they were mainly affected by herpesvirus encephalitis, enterovirus meningoencephalitis, bacterial meningitis (Neisseria meningitidis and Streptococcus pneumoniae), and infection by other etiological agents or unknown pathogen. Their CSF features were compared with HIV-negative patients and native HIV-positive individuals without CNS involvement. 14.3.3 protein was found in bacterial and HSV infections while T-tau and neopterin were abnormally high in the herpesvirus group. P-tau, instead, was elevated in enterovirus meningitis. S-100β was found to be high in patients with HSV-1 and HSV-2 infections but not in those with Varicella Zoster Virus (VZV). Thirty-day mortality was unexpectedly low (2.7%): patients who died had higher levels of T-tau and, significantly, lower levels of Aβ1–42.ConclusionThis work demonstrates that CSF biomarkers of neuronal damage or inflammation may vary during CNS infections according to different causative agents. The prognostic value of these biomarkers needs to be assessed in prospective studies.
Multivariate Base Rates of Low Scores on Tests of Learning and Memory Among Latino Adult Populations
Authors: Rivera Diego , Olabarrieta-Landa Laiene , Brooks Brian L. , Ertl Melissa M. , Benito-Sánchez Itziar , Quijano Maria Cristina , Rodriguez-Irizarry Walter , Aguayo Arelis Adriana , Rodríguez-Agudelo Yaneth , Arango-Lasprilla Juan Carlos 
Published: May 2019

AbstractObjective:To determine the prevalence of low scores for two neuropsychological tests with five total scores that evaluate learning and memory functions.Method:N = 5402 healthy adults from 11 countries in Latin America and the commonwealth of Puerto Rico were administered the Rey–Osterrieth Complex Figure (ROCF) and the Hopkins Verbal Learning Test (HVLT-R). Two-thirds of the participants were women, and the average age was 53.5 ± 20.0 years. Z-scores were calculated for ROCF Copy and Memory scores and HVLT-R Total Recall, Delayed Recall, and Recognition scores, adjusting for age, age2, sex, education, and interaction variables if significant for the given country. Each Z-score was converted to a percentile for each of the five subtest scores. Each participant was categorized based on his/her number of low scoring tests in specific percentile cutoff groups (25th, 16th, 10th, 5th, and 2nd).Results:Between 57.3% (El Salvador) and 64.6% (Bolivia) of the sample scored below the 25th percentile on at least one of the five scores. Between 27.1% (El Salvador) and 33.9% (Puerto Rico) scored below the 10th percentile on at least one of the five subtests. Between 5.9% (Chile, El Salvador, Peru) and 10.3% (Argentina) scored below the 2nd percentile on at least one of the five scores.Conclusions:Results are consistent with other studies that found that low scores are common when multiple neuropsychological outcomes are evaluated in healthy individuals. Clinicians should consider the higher probability of low scores when evaluating learning and memory using various sets of scores to reduce false-positive diagnoses of cognitive deficits.
Availability of neighbourhood supermarkets and convenience stores, broader built environment context, and the purchase of fruits and vegetables in US households
Authors: Peng Ke , Kaza Nikhil 
Published: May 2019

AbstractObjective:To determine whether neighbourhood supermarket and convenience store availability and broader built environment context are associated with food purchasing behaviour in a national population.Design:We used observational data to perform a cross-sectional study of food purchases for US households in 2010. We used three-level mixed-effect regression models to determine whether the associations between the number of neighbourhood supermarkets and convenience stores and the self-reported annual household expenditures for fruits and vegetables were affected by regional destination accessibility, neighbourhood destination diversity, availability of neighbourhood destinations and neighbourhood street connectivity.Setting:Metropolitan statistical areas (n 378) in the USA.Participants:Households (n 22 448).Results:When we controlled for broader built environment context, there was no significant association between availability of neighbourhood supermarkets and expenditures on fruits and vegetables; instead, we observed an inverse association between the number of convenience stores and expenditures for fruits (P = 0·001). The broader built environment context was associated with food purchase, although the magnitude was small: (i) higher regional destination accessibility was associated with higher expenditures for fruits (P &lt; 0·001); (ii) higher neighbourhood destination diversity was associated with lower expenditures for vegetables (P = 0·002); and (iii) higher neighbourhood street connectivity was associated with higher expenditures for fruits (P &lt; 0·001).Conclusions:The broader built environment factors contributed to understanding how people use neighbourhood food stores. However, there was only a small relationship between the broader environment context and fruit and vegetable expenditures. Policy interventions that focus exclusively on increasing the availability of neighbourhood supermarkets likely will not promote fruit and vegetable consumption.
Investigation of ORR Performances on Graphene/Phthalocyanine Nanocomposite in Neutral Medium
Authors: Mukherjee Moumita , Samanta Madhupriya , Das Gour P. , Chattopadhyay Kalyan K. 
Published: May 2019

AbstractThe drive to replace scarce and expensive Pt-based electrocatalysts for oxygen reduction reaction (ORR) has led to the development of a group of electrocatalysts composed of transition-metal ion centers coordinated with four nitrogen groups (M-N4). Among these, metal phthalocyanines (MPcs), due to low cost of preparation, highly conjugated structure as well as high thermal and chemical stability, have received a great interest. The catalytic activity of MPcs can be improved by employing conducting supports. Here, in this report, we have solvothermally synthesized graphene-supported zinc phthalocyanine nanostructures, and their ORR kinetics and mechanism have been investigated in neutral solution (pH = 7) by using the rotating disk electrode technique. The as-synthesized nanocomposite followed a 4e− reduction pathway. The onset potential (−0.04 V versus Ag/AgCl) found in this work can be comparable with other state-of-the-art material, demonstrating good performance in neutral solution. The fascinating performance leads the nanocomposite material toward future energy applications.
Post-operative stereotactic radiosurgery of brain metastases: A single-center retrospective review of clinical outcomes
Authors: Smith Zachary T. , Ashruf Syed U. , Mylander Charles , Thompson Kerry J. , Geraghty Charles , Hasson Brian , Burke Timothy G. , Dad Luqman K. 
Published: May 2019

AbstractAim:We sought to retrospectively report our outcomes using post-operative stereotactic radiosurgery (SRS)/stereotactic radiotherapy (SRT) in place of whole-brain radiation therapy (WBRT) following resection of brain metastases from our hospital-based community practice.Materials and Methods:A retrospective review of 23 patients who underwent post-operative SRS at our single institution from 2013 to 2017 was undertaken. Patient records, treatment plans and diagnostic images were reviewed. Local failure, distant intracranial failure and overall survival were studied. Categorical variables were analyzed using Fisher’s exact tests. Continuous variables were analyzed using Mann–Whitney tests. The Kaplan–Meier method was used to estimate survival times.Results:16 (70%) were single-fraction SRS, whereas the remaining 7 patients received a five-fraction treatment course. The median single-fraction dose was 16 Gy (range, 16–18). The median total dose for fractionated treatments was 25 Gy (range, 25–35). Overall survival at 6 and 12 months was 95 and 67%, respectively. Comparison of SRS versus SRT local control rates at 6 and 12 months revealed control rates of 92 and 78% versus 29 and 14%, respectively. Every patient with dural/pial involvement at the time of surgery had distant intracranial failure at the 12-month follow-up.Findings:Single-fraction frameless SRS proved to be an effective modality with excellent local control rates. However, the five-fraction SRT course was associated with an increased rate of local recurrence. Dural/pial involvement may portend a high risk for distant intracranial disease; therefore, it may be prudent to consider alternative approaches in these cases.
Attitudes and completion of advance care planning: Assessing the contribution of health beliefs about Alzheimer's disease among Israeli laypersons
Authors: Werner Perla , Schiffman Ile Kermel 
Published: May 2019

AbstractObjectivesThe purpose of this study was to assess laypersons’ attitudes and completion of advance care planning (ACP) and to examine associations with sociodemographic characteristics and health beliefs on Alzheimer's disease.MethodsA cross-sectional telephone survey was conducted during April and May 2017, with a sample of 514 Israeli adults, aged 18 years and above. A structured, pretested questionnaire assessing participants’ awareness, attitudes, and completion of ACP, as well as health beliefs on Alzheimer's disease (subjective knowledge, susceptibility, and worry), and sociodemographic factors, was used.ResultsTwo-fifths of the participants had heard of at least one of the terms: advance directives or durable power of attorney. Overall, participants expressed positive attitudes toward ACP. Results of regression models showed that gender, religiosity, and subjective knowledge of Alzheimer's disease were statistically significant correlates of attitudes toward ACP. Adding health beliefs on Alzheimer's disease doubled the amount of the variance explained, from 3% to 6%.Significance of resultsOur results support the use of cognitive models of health behavior by assessing intra-personal beliefs and knowledge to understand ACP attitudes and completion. Specifically, we demonstrated the importance of knowledge of Alzheimer's disease for ACP attitudes, suggesting the importance of including a module on the topic to ACP interventions.
Influence of carrier water pH, foliar fertilizer, and ammonium sulfate on 2,4-D and 2,4-D plus glyphosate efficacy
Authors: Devkota Pratap , Johnson William G. 
Published: May 2019

AbstractCarrier water pH is an important factor for enhancing herbicide efficacy. Coapplying agrochemical products with the herbicide might save time and resources; however, the negative effect of foliar fertilizers on herbicide efficacy should be thoroughly evaluated. In greenhouse studies, the effect of carrier water pH (4, 6.5, and 9), foliar fertilizer (zinc [Zn], manganese [Mn], or without fertilizer), and ammonium sulfate (AMS) at 0% or 2.5% vol/vol was evaluated on 2,4-D and premixed 2,4-D plus glyphosate efficacy for giant ragweed, horseweed, and Palmer amaranth control. In addition, a field study was conducted to evaluate the effect of carrier water pH (4, 6.5, and 9); and Zn or Mn foliar fertilizer on premixed 2,4-D plus glyphosate efficacy for horseweed and Palmer amaranth control. In the greenhouse study, 2,4-D and premixed 2,4-D plus glyphosate provided 5% greater weed control at acidic compared with alkaline carrier water pH. Coapplied Mn foliar fertilizer reduced 2,4-D and premixed 2,4-D plus glyphosate efficacy at least 5% for weed control. Addition of AMS enhanced 2,4-D and premixed 2,4-D plus glyphosate efficacy at least 6% for giant ragweed, horseweed, and Palmer amaranth control. In the field study, few significant differences occurred between coapplied Zn or Mn foliar fertilizer for any treatment variables. Therefore, carrier water pH, coapplied foliar fertilizer, and water-conditioning adjuvants have potential to influence herbicide performance. However, weed species could play a role in the differential response of these factors on herbicide efficacy.
Believe It or Not? Partisanship, Preferences, and the Credibility of Campaign Promises
Authors: Fernandez-Vazquez Pablo , Theodoridis Alexander G. 
Published: May 2019

AbstractWe use a novel survey experiment with a broadly representative sample to reveal an important phenomenon in voter integration of campaign communications: preference-mediated partisan motivation. When evaluating the credibility of candidate position changes on minimum wage policy (a readily quantifiable and salient issue domain), partisans do not take a new stance at face value, apply universal skepticism, or simply afford more credibility to co-partisans. Instead, they process a candidate’s stance through an interaction between the voter’s partisan allegiance and their own policy preference. Partisans update more when a co-partisan moves closer to them than when the candidate shifts away from them. The opposite pattern emerges with the other party’s candidates: partisans tend to be more receptive if the candidate moves away from them. This feature of campaign message acceptance has profound implications for political communication and our understanding of partisan cognition.
Dynamics of Mesoscale Eddies Interacting With a Western Boundary Current Flowing by a Gap
Authors: Yuan Dongliang , Song Xinxin , Yang Ya , Dewar William K. 
Published: May 2019

AbstractThe propagation of cyclonic and anticyclonic mesoscale eddies through a wide meridional gap with a crossing western boundary current (WBC) is studied using a 1.5‐layer quasi‐geostrophic ocean circulation model. The results of the numerical experiments suggest that a steady, leaping WBC blocks nearly completely all eddies from propagating westward through the gap. In comparison, both cyclonic and anticyclonic eddies propagate westward nearly uninterrupted through the gap if the WBC is in a penetrating state. Interactions of mesoscale eddies with a critical‐state WBC trigger regime transitions of the WBC between leaping and penetrating states, resulting in dramatic changes of the circulation west of the gap. The radiation of the circulation plumes from the gap into the western basin due to the WBC regime transition is found to be independent of the size and the initial location of the perturbing eddy in the eastern basin, provided that the WBC path shift is induced successfully by the eddy.
Contrasted Summer Processes in the Sea Ice for Two Neighboring Floes North of 84°N: Surface and Basal Melt and False Bottom Formation
Authors: Provost Christine , Sennéchael Nathalie , Sirven Jérôme 
Published: May 2019

AbstractWe report continuous observations in the high Arctic (north of 84°N) over the full 2013 summer season at two nearby sites with distinct initial snow depth, ice thickness, and altitude with respect to the local ice topography. The two sites, subject to similar atmospheric conditions that did not favor strong ice melt, showed contrasting evolutions. One site, with initially thin sea ice (1.40 m) at a relatively low location of the floe, witnessed the formation of a spectacular 1.20‐m‐deep melt pond, a pond‐enhanced erosion of the ice surface, and a sudden pond drainage into the ocean. Then, the outpoured fresh water rapidly froze, heated the old ice from below, and also acted as a temporary shield from the ocean heat flux while it was progressively ablated through dissolution. Eventually, the site almost recovered its initial ice thickness. In contrast, the other site, with initially thicker sea ice (1.75 m) at a relatively high location on its floe, did not support any significant meltwater and underwent over 0.5 m of continuous basal ablation. The two sites experienced formation of superimposed and interposed ice. Sea ice survived summer melt at the two sites, which entered the refreezing season with similar snow and ice thicknesses. For the first time, processes associated with the formation of a deep melt pond and subsequent false bottom evolution are continuously documented with ice mass balance instruments.
Heterogeneous GM-CSF signaling in macrophages is associated with control of Mycobacterium tuberculosis
Authors: Bryson Bryan D. , Rosebrock Tracy R. , Tafesse Fikadu G. , Itoh Christopher Y. , Nibasumba Armel , Babunovic Gregory H. , Corleis Bjorn , Martin Constance , Keegan Caroline , Andrade Priscila , Realegeno Susan , Kwon Douglas , Modlin Robert L. , Fortune Sarah M. 
Published: May 2019

AbstractVariability in bacterial sterilization is a key feature of Mycobacterium tuberculosis (Mtb) disease. In a population of human macrophages, there are macrophages that restrict Mtb growth and those that do not. However, the sources of heterogeneity in macrophage state during Mtb infection are poorly understood. Here, we perform RNAseq on restrictive and permissive macrophages and reveal that the expression of genes involved in GM-CSF signaling discriminates between the two subpopulations. We demonstrate that blocking GM-CSF makes macrophages more permissive of Mtb growth while addition of GM-CSF increases bacterial control. In parallel, we find that the loss of bacterial control that occurs in HIV-Mtb coinfected macrophages correlates with reduced GM-CSF secretion. Treatment of coinfected cells with GM-CSF restores bacterial control. Thus, we leverage the natural variation in macrophage control of Mtb to identify a critical cytokine response for regulating Mtb survival and identify components of the antimicrobial response induced by GM-CSF.