bluuebunny/crossref_metadata_2025_split huggingface dataset:
Long-term orbital and rotational motions of Ceres and Vesta
Authors: Vaillant T. , Laskar J. , Rambaux N. , Gastineau M. 
Published: September 2018

Context.The dwarf planet Ceres and the asteroid Vesta have been studied by the Dawn space mission. They are the two heaviest bodies of the main asteroid belt and have different characteristics. Notably, Vesta appears to be dry and inactive with two large basins at its south pole. Ceres is an ice-rich body with signs of cryovolcanic activity.Aims.The aim of this paper is to determine the obliquity variations of Ceres and Vesta and to study their rotational stability.Methods.The orbital and rotational motions have been integrated by symplectic integration. The rotational stability has been studied by integrating secular equations and by computing the diffusion of the precession frequency.Results.The obliquity variations of Ceres over [−20 : 0] Myr are between 2° and 20° and the obliquity variations of Vesta are between 21° and 45°. The two giant impacts suffered by Vesta modified the precession constant and could have put Vesta closer to the resonance with the orbital frequency 2s6−sV. Given the uncertainty on the polar moment of inertia, the present Vesta could be in this resonance where the obliquity variations can vary between 17° and 48°.Conclusions.Although Ceres and Vesta have precession frequencies close to the secular orbital frequencies of the inner planets, their long-term rotations are relatively stable. The perturbations of Jupiter and Saturn dominate the secular orbital dynamics of Ceres and Vesta and the perturbations of the inner planets are much weaker. The secular resonances with the inner planets also have smaller widths and do not overlap, contrary to the case of the inner planets.
An imaging spectroscopic survey of the planetary nebula NGC 7009 with MUSE
Authors: Walsh J. R. , Monreal-Ibero A. , Barlow M. J. , Ueta T. , Wesson R. , Zijlstra A. A. , Kimeswenger S. , Leal-Ferreira M. L. , Otsuka M. 
Published: September 2018

Aims. The spatial structure of the emission lines and continuum over the 50″ extent of the nearby, O-rich, PN NGC 7009 (Saturn Nebula) have been observed with the MUSE integral field spectrograph on the ESO Very Large Telescope. This study concentrates on maps of line emission and their interpretation in terms of physical conditions.
Methods. MUSE Science Verification data, in <0.6″ seeing, have been reduced and analysed as maps of emission lines and continuum over the wavelength range 4750–9350 Å. The dust extinction, the electron densities and temperatures of various phases of the ionized gas, abundances of species from low to high ionization and some total abundances are determined using standard techniques.
Results. Emission line maps over the bright shells are presented, from neutral to the highest ionization available (He II and [Mn V]). For collisionally excited lines (CELs), maps of electron temperature (Te from [N II] and [S III]) and density (Ne from [S II] and [Cl III]) are available and for optical recombination lines (ORLs) temperature (from the Paschen jump and ratio of He I lines) and density (from high Paschen lines). These estimates are compared: for the first time, maps of the differences in CEL and ORL Te’s have been derived, and correspondingly a map of t2 between a CEL and ORL temperature, showing considerable detail. Total abundances of only He and O were formed, the latter using three ionization correction factors. However, the map of He/H is not flat, departing by ~2% from a constant value, with remnants corresponding to ionization structures. An integrated spectrum over an area of 2340 arcsec2 was also formed and compared to 1D photoionization models.
Conclusions. The spatial variation of a range of nebular parameters illustrates the complexity of the ionized media in NGC 7009. These MUSE data are very rich with detections of hundreds of lines over areas of hundreds of arcsec2 and follow-on studies are outlined.
Le partage des données génétiques : un nouveau capital
Authors: Stoeklé Henri-Corto , Forster Ninon , Charlier Philippe , Bloch Oudy C. , Hervé Christian , Turrini Mauro , Vogt Guillaume 
Published: September 2018

En l’espace de trois décennies, différentesbiotechs, principalement nord-américaines, sont devenues expertes dans la production, le traitement et l’analyse de volumes considérables de données génétiques. Elles ont dépassé celles des plateformes académiques habituelles grâce à l’appropriation d’un nouveau modèle économique : celui de « marché biface ». Ainsi, en appliquant les idées duweb 2.0, cesbiotechs, interdites en France, permettent aujourd’hui à des millions d’usagers de produire et de « partager » des données, en particulier génétiques, entre eux ou avec des tiers à travers un réseau numérique riche en informations et en services « gratuits ». Mais en réalité, la donnée est devenue un moyen de paiement pour l’accès à ces réseaux et l’usage de ces services. À l’ère de l’économie numérique, le partage des données est devenu synonyme d’échange commercial et la donnée génétique synonyme de capital.
Multiples Myelom
Authors: Boquoi Amelie , Strapatsas Judith , Fenk Roland , Haas Rainer 
Published: September 2018

ZusammenfassungErgebnisse molekularbiologischer Untersuchungen mittels „Whole Genome Sequencing“ haben unser pathophysiologisches Verständnis des Multiplen Myeloms grundlegend
verändert. Wir wissen heute, dass der maligne Plasmazellklon keiner linearen Entwicklung folgt, sondern bereits zu Beginn der Erkrankung multiple Klone
vorhanden sind, die aufgrund ihrer individuellen Dynamik und Expansion die klonale Komposition und damit den Verlauf der Erkrankung bestimmen. Klinisch leitet
sich aus dieser Erkenntnis die Notwendigkeit zur Durchführung von Kombinationstherapien mit synergistischen Wirkungsmechanismen ab, um Überleben und Wachstum
möglichst vieler Klone zu verhindern. Der medizinische Fortschritt hat in den letzten Jahren zur Entwicklung und Zulassung vieler neuer Medikamente geführt,
sodass eine Vielzahl derartiger Kombinationstherapien heutzutage möglich ist und diese auch bei guter Verträglichkeit und mit hoher Lebensqualität durchführbar
sind. Die Effektivität der neuen Behandlungsmethoden – insbesondere der neuen Immuntherapien – ist dabei so hoch, dass erstmalig im Rezidiv der Erkrankung tiefe
Remissionen ohne Nachweis von minimaler Resterkrankung möglich geworden sind. Diese Entwicklung schreitet unverändert voran, sodass sich auch in Zukunft das
Überleben der Patienten weiter verbessern wird.
Agomelatin zur Behandlung der Depression
Authors: Volz H.-P. 
Published: September 2018

ZusammenfassungAgomelatin ist ein innovatives Antidepressivum, das an den melatonergen MT1– und MT2-Rezeptoren agonistisch, an dem serotonergen 5-HT2c-Rezeptor antagonistisch wirkt. Anders als monaminerge Substanzen verfügt Agomelatin über einen positiven Effekt auf bei Depressiven gestörte zirkadiane Parameter wie Schlaf und Aktivitätszyklus. Die Wirksamkeit auf alle Kernsymptome der Depression ist mit anderen modernen Antidepressiva vergleichbar, mitunter ist Agomelatin diesen sogar überlegen. Trotz eines schlafregulierenden Effektes hat die Substanz keine sedierenden Eigenschaften, was sich positiv auf die Tagesaktivität auswirkt. Die Verträglichkeit ist sehr gut, die Häufigkeit der Nebenwirkungen liegt auf Placebo-Niveau. Somit stellt Agomelatin eine wesentliche Bereicherung unserer pharmakologischen Möglichkeiten zur Behandlung der Depression dar.
Caregivers' Perceptions of Their Child's Language Disorder: Alignment between Caregivers and Speech–Language Pathologists
Authors: Selin Jennifer , Schmitt Mary , Hill Margaret 
Published: September 2018

AbstractCaregivers' perceptions regarding their child's language disorder may influence caregivers' involvement in therapy as well as daily home interactions, thus impacting developmental outcomes. However, little is known about the alignment between caregivers' perceptions of their child's language disorder and those of speech–language pathologists (SLPs), nor of factors that might relate to alignment between caregivers and SLPs. This study addressed three aims: (1) to characterize caregivers' perceptions regarding children's quality of communicative interactions, competence in communicative abilities, and outcomes of communicative improvement; (2) to measure alignment between caregivers' and SLPs' perceptions; and (3) to explore caregiver- and child-level factors that might relate to alignment. Caregivers and SLPs of 3- to 4-year-old children currently receiving treatment for language disorders completed questionnaires to assess perceptions along with two caregiver factors (maternal education and self-efficacy) and child language disorder severity. Caregivers' perceptions were more positive and more variable than those of SLPs. However, caregivers and SLPs agreed in rating perceptions of present and future outcomes higher than either quality or competence. Maternal education, caregiver's self-efficacy, and children's language disorder severity were not related to alignment between caregivers and SLPs. Given the variability in caregivers' perceptions, future research should explore the role of perceptions in children's language intervention outcomes.
Management of Microsurgical Patients using Intraoperative Unfractionated Heparin and Thromboelastography
Authors: Zavlin Dmitry , Chegireddy Vishwanath , Jubbal Kevin , Agrawal Nikhil , Spiegel Aldona 
Published: September 2018

Background Maintaining optimal coagulation is vital for successful microvascular tissue transfer. The viscoelastic thromboelastography (TEG) is a modern and dynamic method to assess a patient's coagulation status. The aim of this study was to evaluate its diagnostic capabilities of identifying microvascular complications.
Methods A retrospective chart review was conducted for the most recent 100 cases of abdominal free flap breast reconstruction of a single surgeon. Patient demographics, medical history, clinical, and operative details were documented. Thrombocyte counts, prothrombin time (PT), activated partial thromboplastin time (aPTT), and various TEG parameters were gathered for preoperative, intraoperative, and two postoperative time points.
Results A total of hundred patients were identified, who underwent 172 abdominal-based free flaps for breast reconstruction. TEG was more dynamic compared with PT or aPTT and demonstrated borderline hypocoagulate values intraoperatively upon unfractionated heparin administration and hypercoagulate values postoperatively. In contrast, PT and aPTT demonstrated a continuously hypocoagulable state. Complications included five thrombotic events and three hematomas. The thrombotic cases had much steeper increases of TEG-G between surgery and postoperative day 2 (p = 0.049), while PT and aPTT failed to identify these patients. Of those, two resulted in flap loss (1.2%) that both occurred in patients with abdominal scars from previous surgery.
Conclusion The TEG is a useful adjunct for monitoring coagulation status in microsurgical breast reconstruction. When thrombosis at the anastomosis occurs, TEG correlates with a more rapid rebound from an intraoperative hypocoagulable state to a postoperative hypercoagulable state, when using the TEG. The TEG is a valuable tool for a more dynamic assessment of the patients' changing coagulation status.
Effects of Systemic and Local Caffeine on Vessel Diameter, Anastomosis Patency, and Intimal Hyperplasia in the Rat
Authors: Sakarya Ahmet , Uzun Hakan , Türkkanı Ayten , Çakar Ayşe Nur , Hsieh Yun-Huan , Üstün Galip , Şafak Tunç 
Published: September 2018

Background The use of caffeine is not recommended prior to elective microsurgery due to its demonstrated negative effects on vessel anastomosis by the presumed sympathomimetic induction of vasoconstriction. In this study, we aimed to elucidate the systemic and local effects of caffeine on vessel diameter, anastomosis patency, and degree of intimal hyperplasia during the healing process.
Methods Twenty-five rats were randomly assigned to five groups: (1) negative control, (2) preoperative systemic caffeine, (3) postoperative systemic caffeine, (4) perioperative systemic caffeine, and (5) a local caffeine group. Both the right and left femoral arteries were used. Ten anastomoses were performed per group. The arterial diameter was measured by micrometer, anastomosis patency was assessed surgically and histologically, and the histological examination was conducted 3 weeks postoperatively to determine intimal hyperplasia.
Results The overall patency rate was 96%. Mild vasoconstriction was observed in the systemic caffeine groups (statistically insignificant); however, there were no negative effects on anastomosis patency. Local caffeine irrigation resulted in significant vasodilatation in the local caffeine group (p = 0.001); a similar effect was not observed in the other groups. There was a significant decrease in the intima/media ratio in the local caffeine group (p < 0.01), when compared with the control and systemic caffeine groups. No other intima/media ratio differences were observed among other comparison groups.
Conclusion The systemic administration of caffeine, although statistically insignificant, has an observable effect on vasoconstriction. However, it does not appear to have negative effects on anastomosis patency regardless of its application period (pre-, post-, or perioperatively). The local application of caffeine resulted in considerable vasodilatation as opposed to the vasoconstriction effect in the systemic caffeine groups. Decreased intimal hyperplasia at the anastomosis edge, and antifibrotic properties in the surgical field were also observed in this group. Histologically, the local caffeine group demonstrated an additional beneficial effect on anastomosis remodeling.
The perception and interpretation of sentence types by L1 Spanish–L2 English speakers
Authors: Radu Malina , Colantoni Laura , Klassen Gabrielle , Patience Matthew , Pérez-Leroux Ana Teresa , Tararova Olga 
Published: September 2018

AbstractWhile the L2 perception of segmentals has been investigated, our knowledge of the L2 perception of intonation is limited. Moreover, it is unclear how context affects L1 transfer. This study investigates the perception of English sentence types by adult L1 Spanish speakers across tasks varying in contextual information. In Task 1, participants heard low-pass filtered utterances and identified them as statements, questions or exclamations. Task 2 was similar, but consisted of unaltered utterances. In Task 3, participants heard a scenario and three options (absolute question, declarative question, statement), and selected the best one. Accuracy and reaction times were measured. Learners had the most difficulty in Task 3, but were target-like in the others, confirming previous findings. Namely, L2 speakers perform better in tasks lacking contextual information versus contextualized ones. Thus, while learners maintain their auditory resolution to intonation cues in non-speech tasks, they cannot relate contours to appropriate L2 meanings.
Cylindrical Three-Dimensional Dust-Ion Acoustic Propagation in Plasmas
Authors: El-Labany S. K. , El-Shewy E. K. , Abd El-Razek H. N. , El-Rahman A. A. 
Published: September 2018

Abstract

Wave properties of solitons in an unmagnetized four-component dusty plasma system contains isothermal distributed electrons, mobile ions, and negative-positive dusty grains have been examined. To study DIA wave properties, a reductive perturbation (RP) analysis is used. By a reductive perturbation (RP) analysis under convenient coordinate transformation, the three dimension Kadomtsev-Petviashvili equation in cylindrical coordinates is obtained. The effects of dust grain charge on soliton pulse structures are studied. More specifically, solitary profile depending on the axial, radial, and polar angle coordinates with time is discussed. This investigation may be viable in plasmas of the Earth’s mesosphere.
Investigation of toroidal rotation modulation and momentum transport with electrode biasing in J-TEXT tokamak
Authors: Liu Hai , Chen Zhipeng , Xu Yuhong , Zhu Lizhi , Chen Zhongyong , Zhuang Ge 
Published: September 2018

Abstract
The toroidal rotation modulation and momentum transport have been investigated in the J-TEXT tokamak using a modulated electrode biasing (EB) along with measurements of the toroidal rotation (V

ϕ
) by a spectrometer and a Langmuir-Mach probe array. The amplitude A
v and phase delay ϕ
v (relative to the phase of the biasing current, I
EB) of the rotation modulation are extracted through sine-fitting approaches. It is found that the A
v increases with increasing I
EB and the ϕ
v becomes larger when the modulation frequency increases. It has been estimated that the momentum transport time across a radial range from r/a ∼ 0.9 to 0.65 is about 10 ms, shorter than the half of modulation period (∼30 ms). Using the perturbation analysis technique, the toroidal momentum transport coefficients, including momentum diffusivity χ

ϕ
and convective velocity V
conv, have been calculated and an inward pinch effect has been observed. In addition, the impact of the EB on the ion temperature and intrinsic rotation and the toroidal rotation difference between impurity and main ions are analyzed and discussed.
Effects of Ethanol Plant Proximity and Crop Prices on Land‐Use Change in the United States
Authors: Li Yijia , Miao Ruiqing , Khanna Madhu 
Published: September 2018

AbstractExpansion of ethanol production in the United States has raised concerns regarding its land‐use change effects. However, little is known about the extent to which observed land use change in the United States can be attributed to ethanol plant proximity or is caused by changes in crop prices that may be partly induced by expansion in ethanol production. This study aims to examine the determinants of changes in corn acreage and aggregate crop acreage by simultaneously identifying the effects of establishment of ethanol plants serving as terminal markets for corn and the effects of changes in crop prices in the United States between 2003 and 2014. Our results show that corn acreage and total acreage are fairly inelastic with respect to both changes in ethanol capacity in the vicinity, as well as changes in crop prices. Our estimates of acreage elasticity with respect to corn ethanol production are smaller than those obtained by previous studies that disregard the price effect on crop acreage. We find that, ceteris paribus, the increase in ethanol capacity alone led to a modest 3% increase in corn acreage and less than a 1% increase in total crop acreage by 2012 when compared to 2008. The effect of corn price and aggregate crop price on acreage change from 2008 to 2012 was more than twice larger than that of effective ethanol production capacity over this period; but this price effect was largely reversed by the downturn in crop prices after 2012. This study shows that land‐use change is not a static phenomenon and that it is important to examine how it evolves in response to various factors that may change over time.
Large-scale prediction of binding affinity in protein–small ligand complexes: the PRODIGY-LIG web server
Authors: Vangone Anna , Schaarschmidt Joerg , Koukos Panagiotis , Geng Cunliang , Citro Nevia , Trellet Mikael E , Xue Li C , Bonvin Alexandre M J J 
Published: September 2018

AbstractSummaryRecently we published PROtein binDIng enerGY (PRODIGY), a web-server for the prediction of binding affinity in protein–protein complexes. By using a combination of simple structural properties, such as the residue-contacts made at the interface, PRODIGY has demonstrated a top performance compared with other state-of-the-art predictors in the literature. Here we present an extension of it, named PRODIGY-LIG, aimed at the prediction of affinity in protein-small ligand complexes. The predictive method, properly readapted for small ligand by making use of atomic instead of residue contacts, has been successfully applied for the blind prediction of 102 protein–ligand complexes during the D3R Grand Challenge 2. PRODIGY-LIG has the advantage of being simple, generic and applicable to any kind of protein-ligand complex. It provides an automatic, fast and user-friendly tool ensuring broad accessibility.Availability and implementationPRODIGY-LIG is freely available without registration requirements at http://milou.science.uu.nl/services/PRODIGY-LIG.
AbPredict 2: a server for accurate and unstrained structure prediction of antibody variable domains
Authors: Lapidoth Gideon , Parker Jake , Prilusky Jaime , Fleishman Sarel J 
Published: September 2018

Abstract

Summary
Methods for antibody structure prediction rely on sequence homology to experimentally determined structures. Resulting models may be accurate but are often stereochemically strained, limiting their usefulness in modeling and design workflows. We present the AbPredict 2 web-server, which instead of using sequence homology, conducts a Monte Carlo-based search for low-energy combinations of backbone conformations to yield accurate and unstrained antibody structures.

Availability and implementation
We introduce several important improvements over the previous AbPredict implementation: (i) backbones and sidechains are now modeled using ideal bond lengths and angles, substantially reducing stereochemical strain, (ii) sampling of the rigid-body orientation at the light-heavy chain interface is improved, increasing model accuracy and (iii) runtime is reduced 20-fold without compromising accuracy, enabling the implementation of AbPredict 2 as a fully automated web-server (http://abpredict.weizmann.ac.il). Accurate and unstrained antibody model structures may in some cases obviate the need for experimental structures in antibody optimization workflows.
Neuronal Distribution Across the Cerebral Cortex of the Marmoset Monkey (Callithrix jacchus)
Authors: Atapour Nafiseh , Majka Piotr , Wolkowicz Ianina H , Malamanova Daria , Worthy Katrina H , Rosa Marcello G P 
Published: September 2018

AbstractUsing stereological analysis of NeuN-stained sections, we investigated neuronal density and number of neurons per column throughout the marmoset cortex. Estimates of mean neuronal density encompassed a greater than 3-fold range, from >150 000 neurons/mm3 in the primary visual cortex to ~50 000 neurons/mm3 in the piriform complex. There was a trend for density to decrease from posterior to anterior cortex, but also local gradients, which resulted in a complex pattern; for example, in frontal, auditory, and somatosensory cortex neuronal density tended to increase towards anterior areas. Anterior cingulate, motor, premotor, insular, and ventral temporal areas were characterized by relatively low neuronal densities. Analysis across the depth of the cortex revealed greater laminar variation of neuronal density in occipital, parietal, and inferior temporal areas, in comparison with other regions. Moreover, differences between areas were more pronounced in the supragranular layers than in infragranular layers. Calculations of the number of neurons per unit column revealed a pattern that was distinct from that of neuronal density, including local peaks in the posterior parietal, superior temporal, precuneate, frontopolar, and temporopolar regions. These results suggest that neuronal distribution in adult cortex result from a complex interaction of developmental/ evolutionary determinants and functional requirements.