bluuebunny/crossref_metadata_2025_split huggingface dataset:
Real-life indications to ivabradine treatment for heart rate optimization in patients with chronic systolic heart failure
Authors: Tondi Lara , Fragasso Gabriele , Spoladore Roberto , Pinto Giuseppe , Gemma Marco , Slavich Massimo , Godino Cosmo , Salerno Anna , Montanaro Claudia , Margonato Alberto 
Published: May 2018

Ivabradine is a selective and specific inhibitor of I

f
current. With its pure negative chronotropic action, it is recommended by European Society of Cardiology and American College of Cardiology/American Heart Association guidelines in symptomatic heart failure patients (NYHA ≥ 2) with ejection fraction 35% or less, sinus rhythm and heart rate (HR) at least 70 bpm, despite maximally titrated β-blocker therapy. Data supporting this indication mainly derive from the SHIFT study, in which ivabradine reduced the combined endpoint of mortality and hospitalization, despite the fact that only 26% of patients enrolled were on optimal β-blocker doses. The aim of the present analysis is to establish the real-life eligibility for ivabradine in a population of patients with systolic heart failure, regularly attending a single heart failure clinic and treated according to guideline-directed medical therapy (GDMT). The clinical cards of 308 patients with heart failure with reduced ejection fraction (HFrEF) through a 68-month period of observation were retrospectively analyzed. GDMT, including β-blocker up-titration to maximal tolerated dose, was implemented during consecutive visits at variable intervals. Demographic, clinical and echocardiographic data were collected at each visit, together with 12-leads ECG and N-terminal pro–B-type natriuretic peptide levels. Out of 308 analyzed HFrEF patients, 220 (71%) were on effective β-blocker therapy, up-titrated to effective/maximal tolerated dose (55 ± 28% of maximal dose) (HR 67 ± 10 bpm). Among the remaining 88 patients, 10 (3.2%) were on maximally tolerated β blocker and ivabradine; 21 patients (6.8%), despite being on maximal tolerated β-blocker dose, had still HR ≥70 bpm, ejection fraction 35% or less and were symptomatic NYHA ≥2, being therefore eligible for ivabradine treatment. The remaining 57 (18%) patients were not on β blocker due to either intolerance or major contraindications. Among them, 13 (4%) were taking ivabradine alone. Of the final 44 (14%) patients, 27 (9%) showed an inadequate HR control (74 ± 6 bpm). Of these, only eight (3%) patients resulted to be eligible for ivabradine introduction according to HR and ejection fraction parameters. Overall ivabradine was indicated in 52 patients (16.8%) out of 308 enrolled.
In conclusion, in a carefully managed population of patients with moderate and stable HFrEF, in which optimal GDMT is properly attained, indication to ivabradine treatment is around 17%.
Application of Complex Probiotics in Swine Nutrition – A Review
Authors: Liu Wen Chao , Ye Mao , Liao Jia Hao , Zhao Zhi Hui , Kim In Ho , An Li Long 
Published: May 2018

Abstract
The use of probiotics as alternatives to antibiotics for farm animals is gaining more and more interest during recent years. Probiotics are living microorganisms that provide a wide variety of health benefits to the host when ingested in adequate amounts. The bacterial strains most frequently used as probiotic agents are Bacillus, lactic acid bacteria, Enterococcus and Saccharomyces cerevisiae. It has been suggested that multi-strain probiotics might be more effective than mono-strain probiotics due to the additive and synergistic effects, and many previous studies demonstrated that dietary complex probiotics supplementation had growth promoting effects on pigs. However, the effect of complex probiotics in practice is not always consistent, the effect of probiotic could be affected by strain composition, dosage, feed formula, and the age of animals. In this review, we will give an overview on the current use of complex probiotics for weaning, growing and finishing pigs and sows.
Effect of Postpartum Endocrine Function, Metabolism, and Mastitis on Fertility in High-Yielding Cows – A Review
Authors: Siatka Kamil , Sawa Anna , Krężel-Czopek Sylwia 
Published: May 2018

Abstract
Decreasing fertility in dairy cows, especially in the highest yielders, may be due to excessive metabolic burdens placed on their bodies. Many authors attribute decreasing reproductive efficiency in high-yielding cows to energy deficiencies in early lactation and to associated metabolic and hormonal disorders. The complexity of the issues involved in the efficient reproductive management of cows and the scientifically and practically important understanding of factors affecting fertility in high-producing cows mandate continuous updating of existing knowledge. The aim of this study was to present the effect of postpartum endocrine function, metabolism, and mastitis on fertility in high-yielding cows. Gaining insight into these mechanisms and their relationships with factors such as nutrition and milk yield appears to be crucial for improving dairy cow fertility.
Analysis of Correlations Between Gross and Fine Motor Skills, Physical Fitness, and the Level of Functioning in Schoolchildren with Intellectual Disabilities
Authors: Skowroński Waldemar , Winnicki Witold , Bednarczuk Grzegorz , Rutkowska Izabela , Rekowski Witold 
Published: May 2018

Abstract
Introduction. Physical fitness affects motor and intellectual development. Having a wide range of motor skills makes it possible to learn about the surrounding world and expand one’s knowledge. In the case of persons with intellectual disabilities, mastering gross and fine motor skills is the core of their development and functioning in society. The aim of the study was to analyse the relationship between physical fitness, gross and fine motor skills, and the level of functioning in schoolchildren with intellectual disabilities. Material and methods. The study involved 62 subjects whose age ranged from 9 to 24 years. Due to the large size and homogeneity of the group, the results of 26 subjects were considered in the analysis: 12 girls and 14 boys with moderate intellectual disability. Physical disability as well as gross and fine motor skills were measured with the BOT-2, TGMD- 2, and Eurofit Special tests. The level of functioning in society was assessed with a specially designed ICF-based questionnaire. Results. The study showed that girls had better motor skills than boys; this was reflected in the participants’ level of functioning as girls displayed a higher level of functioning. Boys, despite better physical fitness, were ranked on a lower level of functioning. Conclusions. A relationship was found between gross and fine motor skills and the level of functioning, assessed with BOT-2 and TGMD-2. No relationship was found between physical fitness, assessed with Eurofit Special, and the level of functioning. Instead of using assessment tools for general fitness, one should measure specific motor skills when assessing physical and motor development in children with intellectual disabilities.
Hypotensive Effect Induced by Strength Training Using the Delorme and Oxford Methods in Trained Men
Authors: Corte Jaime Della , Paz Gabriel Andrade , Castro Juliana Brandão Pinto de , Miranda Humberto 
Published: May 2018

Abstract
Introduction. The aim of the study was to investigate the hypotensive responses in normotensive trained individuals after strength training (ST) performed using two training methods: DeLorme and Oxford. Material and methods. Fifteen normotensive trained men (age: 25.1 ± 3.2 years; height: 1.78 ± 0.01 m; BMI: 24.78 ± 1.4 kg/m2) were examined alternately in crossover with an interval of 72 hours between the DeLorme and Oxford methods. Firstly, 10 repetition maximum (RM) loads were obtained. DeLorme (50%, 70%, and 90%) and Oxford (90%, 70%, and 50%) consisted in the manipulation of 10RM loads so that the subjects performed three sets until failure in the Smith Machine (SM) and the Leg Press 45° (LP). Blood pressure was recorded at rest, post-exercise, and until 60 min post-session at 10-min intervals. Results. Both the DeLorme and Oxford methods showed significant intra-protocol reduction in systolic blood pressure (SBP) at 40, 50, and 60 min time points compared to the rest value (F = 21.848; p = 0.0001). Similar results were noted for diastolic blood pressure (DBP) between rest value and the 60 min time point (F = 46.113; p = 0.0001). Conclusions. The DeLorme and Oxford resistance training methods provided similar hemodynamic responses and similar hypotensive effects. Therefore, these methods can be used as alternatives to manipulate training intensity-volume ratio intra-session with low hemodynamic stress.
Why the Military Forces? The Role and Capabilities of Military Forces in the Protection against Disasters
Authors: Hornyacsek Júlia 
Published: May 2018

Abstract
The events of recent times have proven that disasters have become part of our lives. The greatest danger is caused by the damage to and the destruction of the built environment, which makes the population vulnerable. Nowadays, in order to provide effective actions against disasters, complex disaster management systems have evolved throughout Europe, and protection has become an all-society task. Military forces of a given country are also involved in this task. The question arises what kind of damages are caused to the built environment by disasters, how the elimination of damages is resolved and what role the reformed military forces may have in it. In this article, the author has set out to analyze the characteristics of incident sites created by disasters, identifying their impacts on the built environment, as well as the tasks or capabilities needed to perform these tasks. In the light of this, she investigates if military organizations, through their basic function, have all the capabilities that, without special improvements, can make them capable of effectively contributing to the provision of rescue tasks.
Cyber Security Policy and Strategy in the European Union and Nato
Authors: Kovács László 
Published: May 2018

Abstract
Nowadays it is clear not only for professionals but also for outsiders that our advanced Western societies cannot operate without the infrastructure based on information technologies. The security of these infrastructures, which are present in public utilities, economic life, public administration, defence sector or even in the smallest detail of everyday life, have a vital importance. The reason for this is very simple: if these systems do not work, then society does not work either. The importance of cyberspace can no longer be questioned. Accordingly, the challenges and threats to cyberspace have to be addressed at strategic level. This paper presents the most important cyber security principles and strategies of the European Union and NATO.
Redefining Doctrine Concepts in Modern Military Actions
Authors: Neag Mihai-Marcel 
Published: May 2018

Abstract
The mosaic approach to conflict requires redefinition of some doctrinal concepts that can influence the way in which the response to the risks and threats to the state of security, the future of military actions and the acceptance that the technological development will be a factor for the success of the wars future. The issues addressed could be important elements in the architecture of a possible future strategic concept of integrated use of the basic elements of national power - diplomatic, informational, military and economic. At the same time, the results of this theoretical approach can contribute, as a reference point, to proposing viable and innovative doctrinal and operational solutions to counteract aggressions to national security, regardless of their nature or origin.
Evaluation of the Nutrition Effectiveness of the Military Personnel of the Bulgarian Army During the Preparation for Participation in Expeditionary Operations
Authors: Nichev Nikolay 
Published: May 2018

Abstract
The conditions of a resource deficit and the new security environment predetermine the transformation of the logistics system in the Bulgarian Army as one of the most serious challenges facing the adaptation of the Armed Forces of Republic of Bulgaria to the requirements of the modern expeditionary operations. The problems, connected with the organization of the nutrition of the military personnel from the Ministry of Defense and the Bulgarian Army is a process, which is consistent with the contemporary requirements in the sphere of healthy nutrition and food safety, with the European guidelines and recommendations and with the experience of the Bulgarian scientists gained during a long period in this sphere. In result of the given circumstances emerged an unbalance between resources and abilities. This fact together with the challenges of the integrated logistics, require with an increasing keenness the systematic development of defensive abilities of the armed forces of our country and of the military units, participating in expeditionary operations. This development must have balanced abilities, covering all the components for the performance of the full spectrum of tasks, provoked by the expected scenarios and analyses for the development of the military strategy for security, based on a manager’s approach for the expenditure of defensive resources for the logistic supply with food of the units abroad.
The Implications of the Demographic Decrease on National Security
Authors: Obreja Codruț Ștefan , Metea Ileana-Gentilia 
Published: May 2018

Abstract
Nowadays the Romanian Armed Forces are subject to a process of modernization of the defence capabilities, and the process is mainly focussed towards the military assets. However, the human factor is decisive in manipulating the new military technology in accordance with its technical specification. In this context we assess that the process of ensuring the proper human resource is a vulnerability factor, and therefore we tackled the demographic decline as a threat for our national security, as it has been less studied in the last period of time. Considering this social phenomenon as one of great importance for our national security, we conducted a research that would lead to pertinent conclusions regarding the trend of the demographic decline and would provide solutions to increase the number and the quality of human resource selected for the military system.
A Cyber Threat Model of a Nation Cyber Infrastructure Based on Goel-Okumoto Port Approach
Authors: Ogîgău-Neamțiu Florin , Moga Horațiu 
Published: May 2018

Abstract
Information assurance plays a critical role in modern countries around the globe and IT systems are key elements in this environment. Enabling or disabling such capabilities are strategic goals which dramatically influence a nation capacity to perform thus drawing considerate attention of stakeholders. This research defines a method to deal with cyber threats focused on attacker by using the game theory approach and canonic strategies specific to informational war. The cyber threats corresponding risks are treated through the bimatrix game theory and the strategies for Defender and Challenger game players are adapted from the informational war theory. The authors consider cyber-attacks to be a subcomponent of the informational war and thus they can be handled, with minimal alterations, with instruments from the same wide informational war framework.
Perancangan Lean Manufacturing dengan Menggunakan Waste Assessment Model (WAM) dan VALSAT untuk Meminimumkan Waste (Studi Kasus: PT. XYZ)
Authors: Satria Tamzil 
Published: May 2018

<p><em>As an industrial company, XYZ Ltd. engaged in beverages should pay attention to the detailed processes of each line of its production. This aims to minimize potential problems which may occur that can cause losses. This research aimed to minimize waste on the production floor by designing lean manufacturing. Lean manufacturing is an approach that tries to eliminate waste that occurs in the value stream. The method used is Waste Assessment Model (WAM) that functions to identify waste in tea production, and Value Stream Analysis Tools (VALSAT) which functions to select mappingtools used, based on WAM result. From the research result, it was found out that the production time of original tea 450 ml took 20,255.4 seconds and the total lead time of product fulfillment for delivery to customers took 13.23 days. The average reject product was 0.65%, exceeding the company maximum standard. Based on the mapping, recommendation for improvement was given to minimize waste, among others the elimination of Non Value Added (NVA) activity, the application of forecasting, and preventive maintenance activities. This research resulted in the waste identification, which the biggest waste in this company was defect, decreasing the lead time of production time to become 14,767,4 second faster and Process Cycle Efficiency (PCE) which was increased from 39,12% to 53,66%.</em></p>
Les usages scolaires du «Roi grenouille»: le cas des manuels scolaires de l'école et du collège (1995-2016)
Authors: Boutevin Christine Paulette , Richard-Principalli Patricia 
Published: May 2018

« Le Roi grenouille », en tant que conte, relève de la littérature patrimoniale que l’école et le collège se donnent comme objet d’étude, tant dans les listes d’œuvres littéraires de référence de l’école primaire que dans les Programmes du collège. L’article s’appuie sur un corpus de 96 manuels de primaire et de sixième parus entre 1995 et 2016 pour observer comment l’édition scolaire s’est emparée du « Roi grenouille ». Il montre et explique la faible représentation de ce conte des Grimm et la présence importante des détournements auxquels cette œuvre a donné lieu dans ces manuels. Plus spécifiquement, l’analyse de deux manuels proposant une version intégrale du « Roi grenouille » permet de comprendre les enjeux didactiques assignés à sa lecture.
Mots-clefs : Roi grenouille, manuel, usage scolaire, Objets Sémiotiques Secondaires, conte détourné
« Le Roi grenouille » en tant que «crossover»
Authors: Beckett Sandra 
Published: May 2018

« Le Roi-grenouille » constitue ce que la critique anglo-saxonne désigne sous le terme de « crossover », c’est-à-dire un texte adressé à la fois aux adultes et aux enfants. Si ce conte troublant, voire dérangeant, est souvent tronqué, expurgé ou réécrit avant de l’offrir aux enfants, un nombre croissant d’illustrateurs présente une version non aseptisée dans des livres destinés à un public mixte d’enfants et d’adultes. Maurice Sendak, qui n’a jamais cessé de mettre en question la frontière entre littérature adulte et littérature jeunesse, inclut « Le Roi Grenouille » dans son recueil de contes des Grimm publié en 1973. L’auteur de cet article examine les interprétations visuelles du « Roi-Grenouille » créées par des illustrateurs de divers pays qui, comme Sendak, croient que ce conte appartient à tous les âges.
Mots clés: « Le Roi grenouille », conte, «crossover», double public d’enfants et d’adultes, illustration.
Que peuvent entendre des enfants français d'aujourd'hui dans le conte des frères Grimm « Le Roi-grenouille ou Henri-de-fer » ?
Authors: Sève Pierre 
Published: May 2018

Résumé: Cette contribution rend compte du travail d’interprétation que mènent des élèves de 10 ou 11 ans. On constate ainsi que, s’ils sont surpris par la violence de la relation entre la grenouille et la princesse, ils peuvent en élaborer une motivation rationnelle et finalement hautement morale. En revanche, ils sont déroutés par la présence de l’épisode du valet dévoué. Au total, leurs élaborations ne sont pas très différentes des travaux critiques autorisés.
Mots clefs: conte original - réception - enfance - contexte scolaire
Pengaruh Tingkat Edukasi dan Spesialisasi Pendidikan CEO terhadap Performa Perusahaan di Indonesia
Authors: Erlim Kevin Wiyarta , Juliana Rita 
Published: May 2018

Using sample of non financial Indonesia public licted firms over the period from 2005-2014, we analyze the impact of CEO education level education specialization on firm performance. Globalization has a lot of impact on professionals’ careers and thus it will affect the qualification that a CEO needed. We believe that education level and CEO education specialization will affect the managerial decision making process and their strategy. This study is using panel data with fixed effect model methodology. We also did classic assumption test such as autocorrelation test, heteroscedasticity test and cross-sectional dependence test. Our analysis results that CEO education level does have impact on firm performance, and should be considered as an important aspect of a CEO. Keywords: CEO Education Level; CEO Education Specialization; Fixed Effect Model; Firm Performance; TobinsQ
DAMPAK DIMENSI EKUITAS MEREK DALAM MEMBENTUK MINAT BELI ULANG
Authors: Verdilla Vera , Albari Albari 
Published: May 2018

Along with the times, the economy grew by leaps and bounds. Many brands are popping up in the market. Brands competing to attract the attention of consumers. To cope with competition management must first understand the importance of the power contained within the dimensions of their brand equity. For that empirical research is intended to explain the relationship between the dimensions of brand equity, especially the positive influence of consumer repurchase intention. The population in this study are those who have never made a purchase in the clothing brand "G" in Yogyakarta. The sample involved is as much as 166 respondents with a sampling technique in the form of convenience sampling. Variable data used for the analysis is brand awareness, brand image, perceived quality, brand loyalty, and purchase intention. Data were analyzed using multiple linear regression, which is equipped with six types of test data analysis. The results of data analysis showed that brand awareness and brand image positive and significant impact on the perceived quality of the brand. Furthermore, brand awareness, brand image and perceived quality and significant positive effect on brand loyalty. The study also found brand awareness, brand image, perceived quality, brand loyalty and a positive and significant impact on the repurchase intention. In other words, awareness and a positive brand image can affect directly or indirectly (through the perceived quality and brand loyalty) to the repurchase intention. Keywords: Brand Awareness, Brand Image, Perceived Quality, Brand Loyalty, and Purchase Intention