bluuebunny/crossref_metadata_2025_split huggingface dataset:
Technical Note: Feasibility of MRI‐based estimation of water‐equivalent path length to detect changes in proton range during treatment courses
Authors: Uh Jinsoo , Krasin Matthew J. , Hua Chia‐ho 
Published: February 2018

PurposeTo evaluate the feasibility of using on‐treatment magnetic resonance imaging (MRI) to detect proton range changes during treatment courses.MethodsMRI‐based virtual computed tomography (vCT) was generated to calculate water‐equivalent path length (WEPL) at the distal surface of a clinical target volume. T2‐weighted MR images with and without fat suppression were processed by thresholding and fuzzy c‐mean clustering to assign a bulk HU (Hounsfield Unit) to each segment of fat, water, and air. Bony tissues in vCT were transferred from planning CT via a region‐based registration. We validated this method using images from three patients (aged 9, 12, and 17 yr old) with pelvic sarcomas who underwent proton therapy. MRI‐based WEPL was evaluated against those of repeat CT (rCT) and cone beam CT (CBCT).ResultsThe vCT agreed well with the rCT, wherein the use of bulk HU and imperfect bone registration contributed to discrepancies. The 99th percentile error of the MRI‐based WEPL was up to 3.3 mm for posterior fields when we compensated the effect of mobile air. The gamma index (2‐mm WEPL/2‐mm pixel distance) was greater than 99% for those fields. We observed larger errors for anterior fields, which were due to bowel gas movement, mismatched respiratory motion, and differences in patient posture between the vCT and rCT. Applied to multiple on‐treatment MRI of a patient, the estimated WEPL demonstrated an underrange trend, which was consistent with the CBCT results and the increased patient body circumference.ConclusionsThe MRI‐based vCT produced highly accurate WEPL estimates, demonstrating the potential of using on‐treatment MRI for detecting changes in proton ranges.
Validation of the Mood and Feelings Questionnaire (MFQ) and Short Mood and Feelings Questionnaire (SMFQ) in New Zealand help‐seeking adolescents
Authors: Thabrew Hiran , Stasiak Karolina , Bavin Lynda‐Maree , Frampton Chris , Merry Sally 
Published: February 2018

AbstractObjectiveThis study examines the reliability and validity of the Mood and Feelings Questionnaire (MFQ) and Short Mood and Feelings Questionnaire (SMFQ) for measuring depression in New Zealand help‐seeking adolescents.MethodA sample of 183 adolescents completed the 33‐item MFQ, which includes all 13 items on the SMFQ, at three time points during a trial of a computerized intervention for depression.ResultsBoth the MFQ and SMFQ demonstrated good to excellent Cronbach's alphas, moderate to strong item‐total score correlations, moderate to strong correlations with quality of life and anxiety measures, and strong correlations with the clinician‐rated Children's Depression Rating Scale—Revised and the Reynolds Adolescent Depression Scale 2 at all time points, indicating good reliability and content, convergent, and concurrent validities, respectively. Favoring sensitivity over specificity, the optimal cut‐off value for differentiating depressed from nondepressed cases for the MFQ was ≥28 and for the SMFQ was ≥12. Both instruments demonstrated satisfactory diagnostic accuracy and sensitivity to change.ConclusionThe MFQ and SMFQ are free and simple instruments that can be used to identify depression and measure symptom change in New Zealand help‐seeking adolescents.
Impact on quality of life and sexual satisfaction of continent cystostomy with enterocystoplasty in an adult neurologic population
Authors: Lam Van Ba Ornella , Soustelle Laurent , Wagner Laurent , Siegler Nicolas , Boukaram Michel , Naoum Kamel Ben , Droupy Stéphane , Chevrot Armand , Costa Pierre 
Published: February 2018

AimsTo evaluate long‐term general and urinary quality of life (QOL) and sexual satisfaction in adult neurologic patients undergoing continent cystostomy surgery associated with a bladder enlargement to treat neurogenic lower urinary tract dysfunction.MethodsMonocentre, retrospective series of adult neurologic patients who underwent continent cystostomy with bladder enlargement and followed‐up in the long‐term. We assessed during follow‐up, urinary and renal function and patients filled QOL questionnaires on general QOL, sexuality and urinary (short form Qualiveen) disability.ResultsFifty‐three patients were included and followed‐up 77 months on average. Rates of patients’ satisfaction, stomal and urethral continences were respectively of 98.7% (n = 51), 94.1% (n = 48), and 80.4% (n = 41). Impact of surgery on general QOL and autonomy were strong and positive (respective mean scores of 4.8 and 4.7 on a scale ranging from 1 to 5). Mean overall urinary Qualiveen QOL score was 0.8 (0.09‐2.67) indicating a low negative impact of urinary disability on QOL. In patients <45 years, 52.6% (n = 10) reported a moderate to important improvement of their sexuality after surgery. Renal function remained stable during follow‐up.ConclusionIn the long‐term, continent cystostomy with bladder enlargement provides great satisfaction to almost most patients. It has a strong positive impact on general and specific urinary QOL, patients’ autonomy and urinary continence. In young patients a positive impact on sexuality was also noticed. These encouraging data, that need to be confirmed, constitute interesting information to provide to neurologic patients to help them deciding whether they are willing to undergo continent cystostomy surgery.
Prevalence and risk of sport types to stress urinary incontinence in sportswomen: A cross‐sectional study
Authors: Hagovska Magdaléna , Švihra Ján , Buková Alena , Dračková Dana , Švihrová Viera 
Published: February 2018

ObjectiveThe objective of our study was to investigate the prevalence and risk of developing stress urinary incontinence (SUI) in each type of high‐intensity sport, and the associated impact on quality of life in sportswomen.MethodsThis cross‐sectional study was conducted between March and November 2016. The study included 278 sportswomen. The basic inclusion criteria were being nulliparous and engaging in high‐intensity physical activity. The exclusion criteria were childbirth, surgical treatment of gynecological and urological illnesses and urinary tract infection. For evaluation were used: The International Physical Activity Questionnaire (IPAQ), The International Consultation on Incontinence Questionnaire Urinary Incontinence (ICIQ‐UISF), the Overactive Bladder Questionnaire (OAB‐q), the Urinary Incontinence Quality of Life Scale (I‐QOL).ResultsThe highest percentage of SUI was found in athletes (23.8%), followed by volleyball players (19.6%). We found that cumulative metabolic equivalent (MET) did not affect SUI, but the type of sport did. The risk of SUI was highest in volleyball sportswomen (odds ratio[OR] = 2.16,95% confidence interval[CI] = 0.96–4.89, P < 0.05) and athletes (OR = 2.56,95%CI = 0.87–7.51, P = 0.08). As assessed by the I‐ QOL, SUI in people who participated in fitness and athletics (e.g., basketball, volleyball and handball) had a negative impact on quality of life including behavior, psychosocial impacts and social embarrassment score.ConclusionVolleyball players have a 116% chance of getting SUI compared to women who play other types of sports that were analyzed as part of this study. Healthcare professionals should inform the population of sportswomen with risk factors for SUI in order to implement preventive physiotherapy for strengthening pelvic floor muscles.
Physicochemical Stability and Sterility of Standard Parenteral Nutrition Solutions and Simulated Y‐Site Admixtures for Neonates
Authors: Riera Pau , Garrido‐Alejos Gemma , Cardenete Joana , Moliner Elisenda , Zapico‐Muñiz Edgar , Cardona Daniel , Garin Noe 
Published: February 2018

AbstractBackgroundParenteral nutrition (PN) is frequently needed in neonatal intensive care. The use of standard PN has emerged as an easy‐to‐prescribe approach that allows one to have on‐site, ready‐to‐use PN. The aim of this study was to test the physicochemical stability and sterility of 2 specific PN solutions as well as simulate Y‐site compatibility with lipid injectable emulsions (ILE).MethodsOur study considered 2 standard ILE–free PN solutions according to neonatal weight. These solutions were prepared in duplicate and stored at 4°C. The following physicochemical parameters were tested: visual alterations, turbidity, pH, osmolarity, and calcium concentration. Sterility was assessed by means of agar blood culture and glucose concentration determination. In addition, we assessed the stability of simulated Y‐site admixtures. For each standard ILE‐free PN solution, 2 3‐in‐1 PN admixtures were designed, considering extreme values of fluid requirements (50 and 150 ml/kg/d) and a fat supply of 2 g/kg/24 h. The physicochemical parameters tested were phase separation and fat mean droplet size distribution.ResultsNo alterations were detected by visual inspection. Calcium concentrations, turbidity, pH, and osmolarity values remained stable in all the determinations. All agar blood cultures were negative and glucose concentration was constant over time. Physical stability of simulated Y‐site admixtures was considered acceptable as mean droplet size distribution remained below 500 nm in all the emulsions.ConclusionThe 2 tested standard ILE‐free PN solutions for neonates are physicochemically stable and sterile for 31 days under refrigeration (4°C). These solutions are also stable in case of Y‐site administration with ILE at the conditions tested.
Prevalence of potential sexual abuse in adolescents and young adults and feasibility of an assessment and management plan used in three research projects
Authors: Morrow Charlene , Thomas Rachel , Ding Lili , Kahn Jessica A. 
Published: February 2018

ABSTRACTThe aims of this study were to examine the feasibility of a protocol to assess for assessment and response to potential sexual abuse (defined as self‐report of sexual initiation before age 13) among adolescent and young adult research participants in human papillomavirus (HPV) vaccination screening; determine the proportion of participants whose survey responses indicated potential sexual abuse and assess whether age, gender, race, and recruitment site were associated with potential abuse. We pooled data from three cross‐sectional studies of 13–26 year‐old women and men (N = 1541) recruited at a Teen Health Center (THC) and Health Department (HD). Using written and electronic documentation, we demonstrated feasibility by the following outcomes: 100% of participants who indicated early sexual initiation were interviewed by the research staff, 100% of assessments were disclosed to participants’ primary care clinicians, and no adverse consequences of the interviews or referrals occurred. Potential sexual abuse was identified in 95 participants (6.2%). In multivariable logistic regression, the following factors were independently associated with potential abuse: race (Black vs. White, odds ratio [OR] = 3.0, 95% confidence interval [CI] = 1.6–5.7; other race vs. White, OR = 2.6, 95%CI = 1.0–6.5); and recruitment site (HD vs. THC, OR = 2.1, 95%CI = 1.4–3.3). The standardized protocol to identify, assess and refer youth who may have been sexually abused was feasible and can enable researchers to ensure the safety of study participants.
A possible case of symbolic trepanation in Neolithic Central Germany
Authors: Nicklisch Nicole , Dresely Veit , Orschiedt Jörg , Ramsthaler Frank , Schlenker Björn , Ganslmeier Robert , Friederich Susanne , Meller Harald , Alt Kurt W. 
Published: February 2018

AbstractManipulations on prehistoric skulls such as trepanations are among the most fascinating palaeopathological findings though it is not always easy to make a firm diagnosis. This case study presents a lesion on the cranial vault of a Late Neolithic burial in Central Germany. The defect forms an almost lanceolate lesion along the sagittal suture, which had not penetrated the cranial vault. Similar lesions have been found in other areas of Germany and in the Balkans, where they have been interpreted as aborted, incomplete, or symbolic trepanations. This study explores potential causes for the unusual lesion and outlines possible therapeutic reasons for the manipulation of the skull. Comparison with similar cases also raises the question of a symbolic or ritual context. Thus, the study supports the hypothesis of symbolic surgical head manipulation in the European Neolithic.
The impact of the Inca Empire in Northwest Argentina: Assessment of health status and food consumption at Esquina de Huajra (Quebrada de Humahuaca, Argentina)
Authors: Gheggi M. S. , Williams V. I. , Cremonte M. B. 
Published: February 2018

AbstractThe Inca Empire annexed the modern territory of Northwest Argentina ca. 1450 AD. Inca presence manifested regionally with different intensity, highlighting that the Empire carried out different strategies when interacting with conquered populations even within the same region. Regional fluctuations in power centralization may affect the quality of life of local groups, regarding access to food, labour, conflict, or inequality. In this paper, we analyse stable isotopes, dental, and osteological information to evaluate if the individuals that inhabited the archaeological site Esquina de Huajra (Quebrada de Humahuaca, Jujuy) experienced a deprived life quality under Inca administration. Isotopic results signal a balanced diet composed of both vegetal and animal resources, and skeletal indicators of health do not suggest a population undergoing stress.
An algorithm for predicting Robin sequence from fetal MRI
Authors: Resnick Cory M. , Kooiman Tessa D. , Calabrese Carly E. , Zurakowski David , Padwa Bonnie L. , Koudstaal Maarten J. , Estroff Judy A. 
Published: February 2018

AbstractBackgroundInfants with Robin sequence (RS) may present with airway compromise at delivery. Prenatal diagnosis would improve preparation and postnatal care. The purpose of this study was to devise a predictive algorithm for RS based on fetal magnetic resonance imaging (MRI).MethodsRetrospective case‐control study including fetal MRIs from 2002 to 2017. Inclusion criteria were (1) MRI of adequate quality, (2) live‐born infant, and (3) postnatal evaluation. Subjects were grouped on the basis of postnatal diagnosis: (1) RS (micrognathia, glossoptosis, airway obstruction), (2) micrognathia without airway obstruction (“micrognathia”), (3) cleft lip and palate (“CLP”), and (4) gestational age–matched controls. A series of possible predictive variables were assessed on MRI. Receiver operator curves were applied to identify cut‐off values, and a multivariable algorithm was developed.ResultsA total of 162 subjects with mean gestational age at MRI of 25.6 ± 4.9 weeks were included: RS, n = 27 (17%); micrognathia, n = 35 (22%); CLP, n = 46 (28%); control, n = 54 (33%). Three variables were independent predictors of RS: (1) Veau I/II cleft palate (OR = 38.8), (2) tongue shape index (>80%; OR = 8.7), and (3) inferior facial angle (<48°; OR = 14.5).ConclusionMRI findings of cleft palate, TSI >80% and IFA <48° indicate a 98% probability of RS, whereas a lack of all 3 features denotes a likelihood of 1%.
The Long History of the Diverse Roles of Short ORFs: sPEPs in Fungi
Authors: Erpf Paige E. , Fraser James A. 
Published: February 2018

AbstractSince the completion of the genome sequence of the model eukaryote Saccharomyces cerevisiae, there have been significant advancements in the field of genome annotation, in no small part due to the availability of datasets that make large‐scale comparative analyses possible. As a result, since its completion there has been a significant change in annotated ORF size distribution in this first eukaryotic genome, especially in short ORFs (sORFs) predicted to encode polypeptides less than 150 amino acids in length. Due to their small size and the difficulties associated with their study, it is only relatively recently that these genomic features and the sORF‐encoded peptides (sPEPs) they encode have become a focus of many researchers. Yet while this class of peptides may seem new and exciting, the study of this part of the proteome is nothing new in S. cerevisiae, a species where the biological importance of sPEPs has been elegantly illustrated over the past 30 years. Here the authors showcase a range of different sORFs found in S. cerevisiae and the diverse biological roles of their encoded sPEPs, and provide an insight into the sORFs found in other fungal species, particularly those pathogenic to humans.
Secretome Analysis of Hypoxia‐Induced 3T3‐L1 Adipocytes Uncovers Novel Proteins Potentially Involved in Obesity
Authors: Laria Anna Elisa , Messineo Sebastiano , Arcidiacono Biagio , Varano Mariaconcetta , Chiefari Eusebio , Semple Robert K. , Rocha Nuno , Russo Diego , Cuda Giovanni , Gaspari Marco , Brunetti Antonio , Foti Daniela P. 
Published: February 2018

AbstractIn the obese state, as adipose tissue expands, adipocytes become hypoxic and dysfunctional, leading to changes in the pattern of adipocyte‐secreted proteins. To better understand the role of hypoxia in the mechanisms linked to obesity, we comparatively analyzed the secretome of murine differentiated 3T3‐L1 adipocytes exposed to normoxia or hypoxia for 24 h. Proteins secreted into the culture media were precipitated by trichloroacetic acid and then digested with trypsin. The peptides were labeled with dimethyl labeling and analyzed by reversed phase nanoscale liquid chromatography coupled to a quadrupole Orbitrap mass spectrometer. From a total of 1508 identified proteins, 109 were differentially regulated, of which 108 were genuinely secreted. Factors significantly downregulated in hypoxic conditions included adiponectin, a known adipokine implicated in metabolic processes, as well as thrombospondin‐1 and ‐2, and matrix metalloproteinase‐11, all multifunctional proteins involved in extracellular matrix (ECM) homeostasis. Findings were validated by Western blot analysis. Expression studies of the relative genes were performed in parallel experiments in vitro, in differentiated 3T3‐L1 adipocytes, and in vivo, in fat tissues from obese versus lean mice. Our observations are compatible with the concept that hypoxia may be an early trigger for both adipose cell dysfunction and ECM remodeling.
Experiences and unmet needs of lesbian, gay, and bisexual people with cancer care: A systematic review and meta‐synthesis
Authors: Lisy Karolina , Peters Micah D.J. , Schofield Penelope , Jefford Michael 
Published: February 2018

AbstractObjectivesTo explore the cancer care experiences and unmet needs of people who identify as a sexual or gender minority.MethodsA qualitative systematic review and meta‐synthesis was undertaken based on a registered protocol. Following literature searching and study selection, study quality was examined by using the Critical Appraisal Skill Programme Checklist. Qualitative data were extracted verbatim from included studies and synthesized by using thematic analysis.ResultsFifteen studies that included lesbian, gay, and bisexual (LGB) people living with or beyond cancer were included in the review. Studies including gender minorities were not identified. Most of the study participants were sexual minority women with breast cancer or sexual minority men with prostate cancer. Meta‐synthesis of 106 individual findings generated 6 overarching themes pertaining to sexual orientation disclosure, experiences and fear of homophobia, positive and negative health‐care professional behaviors, heterocentric systems and care, inadequacy of available support groups, and unmet needs for patient‐centered care and LGB‐specific information. Lesbian, gay, and bisexual people often reported feelings of anxiety, invisibility, isolation, and frustration throughout the cancer care continuum.ConclusionsAnalysis of the experiences of LGB people with cancer care shows that LGB people face numerous challenges due to their sexual orientation and receive care that does not adequately address their needs. Training and education of health‐care professionals are strongly recommended to address some of these challenges and practice gaps. Culturally appropriate care includes avoiding heterosexual assumptions, use of inclusive language, the provision of tailored information, and involving partners in care.
Following patient pathways to psycho‐oncological treatment: Identification of treatment needs by clinical staff and electronic screening
Authors: Loth Fanny L. , Meraner Verena , Holzner Bernhard , Singer Susanne , Virgolini Irene , Gamper Eva M. 
Published: February 2018

AbstractObjectiveIn this retrospective investigation of patient pathways to psycho‐oncological treatment (POT), we compared the number of POT referrals before and after implementation of electronic screening for POT needs and investigated psychosocial predictors for POT wish at a nuclear medicine department.MethodsWe extracted medical chart information about number of referrals and extent of follow‐up contacts. During standard referral (November 2014 to October 2015), POT needs were identified by clinical staff only. In the screening‐assisted referral period (November 2015 to October 2016), identification was supported by electronic screening for POT needs. Psychosocial predictors for POT wish were examined using logistic regression.ResultsWe analysed data from 487 patients during standard referral (mean age 56.4 years; 60.2% female, 88.7% thyroid carcinoma or neuroendocrine tumours) of which 28 patients (5.7%) were referred for POT. Of 502 patients in the screening‐assisted referral period (mean age 57.0 years; 55.8% female, 86.6% thyroid carcinoma or neuroendocrine tumours), 69 (13.7%) were referred for POT. Of these, 36 were identified by psycho‐oncological (PO) screening and 33 by clinical staff. After PO‐screening implementation, referrals increased by a factor of 2.4. The strongest predictor of POT wish was depressive mood (P < .001). During both referral periods, about 15% of patients visited the PO outpatient unit additionally to inpatient PO consultations.ConclusionsOur results provide evidence from a real‐life setting that PO screening can foster POT referrals, reduce barriers to express the POT wish, and hence help to meet psychosocial needs of this specific patient group. Differences between patients' needs, wish, and POT uptake should be further investigated.
Lignin‐Containing Self‐Nanoemulsifying Drug Delivery System for Enhance Stability and Oral Absorption of trans‐Resveratrol
Authors: Dai Lin , Zhu Weiyan , Liu Rui , Si Chuanling 
Published: February 2018

AbstractSelf‐nanoemulsifying drug delivery system (SNEDDS) is recently studied for enhancing the bioavailability of hydrophobic drugs, such as resveratrol (RSV). However, the functional design of SNEDDS for the drug structural protection is not studied yet. Here, this paper presents an efficient approach by adding lignin (a kind of abundant biomass resource) to enhance the stability of trans‐RSV and meantime improve its oral bioavailability. Higher stability of trans‐RSV (just decreased 2% to cis‐RSV after 1 h under direct sunlight) is observed after loaded by lignin‐containing SNEDDS (RSV/SLS SNEDDS). Low toxicity, high transfer efficiency (apparent permeability coefficient >1 × 10−7 cm s−1), and bioavailability (1.371%) of RSV/SLS SNEDDS is successfully demonstrated in Caco‐2 cells and rat model, respectively. This study serves to illustrate a simple, versatile, environmental, and economic sustainability approach to the development of nanodelivery systems for light instability drugs.