bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reduction of silver nanoparticle toxicity affecting ammonia oxidation using cell entrapment technique
Authors: Giao Nguyen Thanh , Limpiyakorn Tawan , Thuptimdang Pumis , Ratpukdi Thunyalux , Siripattanakul-Ratpukdi Sumana 
Published: February 2019

Abstract
Occurrence of silver nanoparticles (AgNPs) in wastewater treatment systems could impact the ammonia oxidation (AO). This study investigated the reduction of AgNPs and dissociated silver ion (Ag+) toxicity on nitrifying sludge using cell entrapment technique. Three entrapment materials, including barium alginate (BA), polyvinyl alcohol (PVA), and a mixture of polyvinyl alcohol and barium alginate (PVA-BA), were applied. The BA beads provided the highest reduction of silver toxicity (up to 90%) and durability. Live/dead assays showed fatality of entrapped cells after exposure to AgNPs and Ag+. The maximum AO rate of the BA-entrapped cells was 5.6 mg-N/g-MLSS/h. The AO kinetics under the presence of silver followed an uncompetitive inhibition kinetic model. The experiments with AgNPs and Ag+ gave the apparent maximum AO rates of 4.2 and 4.8 mg-N/g-MLSS/h, respectively. The apparent half-saturation constants of the BA-entrapped cells under the presence of silver were 10.5 to 13.4 mg/L. Scanning electron microscopic observation coupled with energy-dispersive X-ray spectroscopy indicated no silver inside the beads. This elucidates that the silver toxicity can be reduced by preventing silver penetration through the porous material, leading to less microbial cell damage. This study revealed the potential of the entrapment technology for mitigating the effect of silver species on nitrification.
Modular Versus Monoblock Hemiarthroplasty in Trauma: A 5-Year Retrospective Analysis of Radiographic and Clinical Outcomes
Authors: Kan Heng , McBride Andrew , McLean Andrew , O’Callaghan William B. , Khan Hussain Ijaz , Gallie Price 
Published: February 2019

Introduction:
Displaced intraarticular neck of femur fractures for low-demand patients are primarily managed with hemiarthroplasty. The optimal implant design for modularity is unclear. Globally and within Australia, the use of monoblock implants varies significantly by location; however, monoblock use is decreasing in Australia in favour of modular systems, with little evidence-based explanation. This study aimed to compare the radiological and clinical outcomes of monoblock and modular hemiarthroplasties.

Methods:
This retrospective cohort study involved patients who underwent hemiarthroplasty for neck-of-femur fractures between 2009 and 2013 at the Gold Coast University Hospital. Leg length and femoral offset were measured from post-operative pelvic radiographs. Revision and mortality rates were extracted from hospital medical records and Australian Joint Registry data.

Results:
A total of 249 patients were evaluated (112 with modular and 147 with monoblock implants). Patient demographics were comparable between the treatment groups; however, the monoblock group comprised significantly older persons. No between-group differences in leg length discrepancies were identified. Femoral offset was under-restored on average by 5.86mm (p<0.05) compared to the uninjured side within the monoblock group. Mortality rates were significantly higher in the monoblock group (23% vs 12%, P=0.026) at the 1-year mark. No significant between-group differences were found in 30-day mortality, length of stay, or revision rates.

Discussion:
Modular hemiarthroplasty was superior for restoring offset in our cohort, but no group differences were noted for leg length. While modular implants seemed better for restoring normal hip anatomy and were associated with a lower 1-year mortality rate, no other advantages were found.
Media Baru dan Nasionalisme Anak Muda: Pengaruh Penggunaan Media Sosial ‘Good News From Indonesia’ Terhadap Perilaku Nasionalisme
Authors: Wibisono Gunawan 
Published: February 2019

Perkembangan media baru tak bisa dipungkiri telah merasuki hampir seluruh lini kehidupan manusia. Teknologi telah menjadi bagian dari kehidupan sehari-hari. Salah satu yang paling kentara adalah penggunaan media baru. Berbagai jenis kebutuhan hidup seperti alat komunikasi, akses informasi, berbelanja hingga alat transportasi dengan sangat mudah digunakan melalui media baru. Selain itu, media baru juga bisa menjadi platform penebar kabar baik yang bisa membangkitkan semangat positif. Di tengah merebaknya berita-berita bohong atau hoax yang kerap muncul di Indonesia, di saat itu pula muncul beberapa media alternatif. Salah satunya adalah situs Good News From Indonesia. Hipotesis penelitian ini bertujuan untuk membuktikan apakah ada pengaruh penggunaan media sosial Good News From Indonesia terhadap perilaku nasionalisme anak muda. Jenis penelitian ini adalah kuantitatif dengan pendekatan regresi linier. Sampel penelitian ini sebanyak 270 responden dari para pengguna media sosial GNFI. Berdasarkan uji t test, hasil menunjukkan bahwa t hitung > t tabel, maka H0 ditolak dan H1 diterima dengan nilai t hitung 5,982 > 1,285. Berdasarkan pada koefisien regresi, menunjukkan bahwa perilaku nasionalisme dipengaruhi atas penggunaan situs website gnfi sebesar 15,47%, sedangkan sisanya 84,53% dipengaruhi oleh variabel lainnya, Di tengah derasnya arus informasi pada era global, penelitian ini telah membuktikan bahwa penggunaan media sosial GNFI berpengaruh signifikan terhadap perilaku nasionalisme.
Kebijakan, Risiko, dan Perlindungan Sosial Alternatif dalam Transisi Pemuda di Jawa Tengah
Authors: Budiman Muhammad Rosyid , Syahbanaf Farid Ali , Nurhasanah Yanti , Widhyharto Derajad Sulistyo , Pratama Aditya Rizki 
Published: February 2019

Jawa Tengah merupakan provinsi dengan persentase penduduk miskin terbesar di Pulau Jawa. Tingginya angka kemiskinan disebabkan berbagai faktor yang saling terkait seperti birokrasi dan pemerintahan, ketersediaan infrastruktur, serta akses pendidikan dan informasi. Salah satu masalah terpenting terkait birokrasi dan pemerintahan di Indonesia adalah mengenai belum optimalnya pelaksanaan perlindungan sosial. Studi ini menggunakan metode kualitatif untuk menganalisa pemuda rentan (miskin dan difabel) di Jawa Tengah dengan mengetahui bagaimana mereka melalui transisi menuju dunia kerja tanpa sistem perlindungan sosial yang memadai. Tanpa perlindungan sosial yang memadai pemuda dihadapkan pada risiko-risiko tanpa proteksi dari negara. Permasalahan terkait ketersediaan pendidikan, jaminan kesehatan, dan ketersediaan lapangan kerja adalah beberapa isu strategis yang menjadi perhatian. Dengan peran pemerintah yang belum optimal, pemuda diharuskan mencari alternatif untuk melindungi diri dari risiko-risiko seperti putus sekolah, pengangguran, dan kemiskinan yang berkelanjutan. Pemuda rentan di Jawa Tengah mengambil pilihan-pilihan yang berbeda sesuai dengan tantangan yang dihadapi dan pilihan yang tersedia. Terdapat perbedaan pilihan yang diambil oleh pemuda daerah pinggir (periphery) seperti Jawa Tengah dengan pemuda dari daerah pusat seperti Jakarta. Perbedaan akses terutama pada infrastruktur fisik dan akses informasi menjadi salah satu pembeda utama pilihan-pilihan yang dimiliki dan diambil oleh pemuda rentan dalam mencari alternatif substitusi perlindungan sosial formal dari pemerintah.
Implementasi Kebijakan Strategi dengan Balanced Scorecard pada Kementerian Kelautan dan Perikanan
Authors: Nurcholis Muhammad Aris , Satria Arif 
Published: February 2019

Untuk melaksanakan amanat Reformasi Birokrasi khususnya program penguatan akuntabilitas serta dalam rangka meningkatkan kinerja, Kementerian Kelautan dan Perikanan (KKP) telah menetapkan kebijakan untuk mengimplementasikan manajemen kinerja dengan pendekatan Balanced Scorecard (BSC) dalam proses penyusunan Rencana Strategis sejak tahun 2013. Tujuan penelitian adalah untuk mengevaluasi implementasi strategi BSC di KKP ditinjau dari faktor-faktor yang menentukan keberhasilannya dan prinsip-prinsip organisasi yang berfokus pada strategi. Merumuskan suatu usulan agar implementasi strategi BSC di KKP mampu mempercepat reformasi birokrasi. Penelitian ini menggunakan metode penelitian sequential explanatory research. Data diambil dari 231 responden pegawai KKP dan dilanjutkan dengan wawancara mendalam terhadap 8 responden pimpinan. Hasil penelitian menunjukkan bahwa keberhasilan implementasi strategi di KKP ditentukan oleh kualitas faktor-tahapan strategi dan faktor-faktor yang mendukung implementasi strategi. Diantara faktor-faktor kualitas tahapan strategi, kejelasan visi dan misi mempunyai peran yang paling menentukan. Sedangkan proses perbaikan adalah faktor pendukung yang paling menentukan. Sedangkan faktor pendukung yang masih kurang dan harus diperbaiki adalah dukungan anggaran, kompetensi SDM, dan peran unit manajemen strategi. Secara umum implementasi strategi menggunakan Balanced Scorecard telah dipahami dan digunakan dengan baik oleh para pucuk pimpinan dan pegawai KKP untuk pencapaian visi dan misi organisasi. Keywords: Implementasi Strategi, Kebijakan, Balanced scorecard, Kementerian Kelautan dan Perikanan
OPTIMALISASI KERJASAMA PERDAGANGAN BARANG FORUM RCEP BAGI INDONESIA
Authors: Abdullah Ragimun 
Published: February 2019

RCEP dibentuk sebagai wujud dari respon ASEAN terhadap dinamika ekonomi di kawasan dan global berupa integrasi ASEAN dengan perekonomian global. RCEP memiliki tujuan progresif menghapuskan tarif dan hambatan non-tarif serta memfasilitasi dan meningkatkan transparansi antar negara anggota. Penyatuan 16 negara dalam satu skema perjanjian perdagangan bebas akan menjadikan RCEP menjadi blok perdagangan besar sepertiga dunia. Penelitian ini bertujuan menganalisis optimalisasi perdagangan barang dengan diberlakukannya RCEP dan upaya-upaya yang dapat dilakukan untuk mengoptimalkan manfaat atas perdagangan barang. Dalam penelitian ini digunakan pendekatan deskriptif. Salah satu upaya peningkatan ekspor jangka menengah dapat dicapai juga dengan mempercepat penyelesaian perundingan RCEP khususnya terkait tiga isu penting yaitu isu perdagangan barang (trade in goods), perdagangan jasa (trade in services), dan investasi. mendorong transformasi struktur ekspor dari berbasis komoditi ke produk dan jasa bernilai tambah, memanfaatkan secara penuh skema preferensi yang ada selama ini ada, menargetkan pasar secara spesifik, fokus pada skala untuk membantu perbaikan neraca perdagangan serta menyusun “negative list” negara2 tujuan ekspor yang selama ini perlu dioptimalkan seperti China, Jepang dan Korea Selatan.
Macro Stress Test Model Risiko Kredit: Studi Empiris Perbankan Konvensional dan Syariah di Indonesia
Authors: Indra Indra 
Published: February 2019

Tulisan ini berfokus pada pengembangan model yang mampu melakukan pengujian tekanan makro (macro stress test) terhadap risiko kredit perbankan konvensional dan perbankan syariah di Indonesia dengan menggunakan beberapa analisis sekenario. Tujuannya adalah untuk menginvestigasi sekaligus mengkomparasi daya tahan sistem keuangan kedua sistem perbankan tersebut dari berbagai guncangan makro. Variabel risiko kredit yang digunakan adalah NPL untuk perbankan konvensional dan NPF untuk perbankan syariah. Variabel makro eksogenus yang digunakan adalah Produk Domestik Bruto, Kurs, Indeks Harga Konsumen, dan Tingkat Suku Bunga. Spesifikasi model yang digunakan adalah ARDL , yang diestimasi untuk setiap tipe kredit perbankan yang diklasifikasikan ke dalam 9 (sembilan) sektor dan total seluruh sektor. Studi ini menemukan bahwa, penurunan PDB, depresiasi kurs, kenaikan IHK (inflasi) dan tingkat suku bunga (BI Rate) berkontribusi dalam mendorong kenaikan level NPL maupun NPF. IHK (inflasi) merupakan sumber kerentanan terbesar bagi risiko kredit pada kedua kelompok bank, diikuti oleh PDB, Kurs, dan tingkat suku bunga. Fakta ini mengindikasikan bahwa kerentanan sistem keuangan pada kedua kelompok bank tidak hanya bergantung pada kinerja internal pada setiap bank, namun juga dinamika makro eksternal. Hasil ini mengkonfirmasi bahwa meski bank syariah dan bank konvensional menggunakan sistem operasi yang berbeda, namun keduanya tidak terlepas dari dinamika makroekonomi yang terjadi.
ANALISIS SALURAN PEMASARAN KOMODITAS PANGAN (BERAS, JAGUNG, BAWANG, CABAI DAN DAGING SAPI) DI SUMATERA UTARA
Authors: Riyadh Muhammad Ilham 
Published: February 2019

AbstractLess availability food, and lame path distribution from producer to consumers . show that system production and system distribution some food disturbed because quality means and infrastructure transport many broken So the increase price at the level consumer far more big compared with increase price at the producer level . the objectives reviewed, 1) : For to know commodity supply channels food 2) For knowing efficient system commerce on channel system commerce . 3) For knowing Policy system commerce commodities food . the Research do at five district namely : district Simalungun , Karo , Dairi ,Tapanuli and North Langkat . Analytical method with marketing margin analysis , farmer's share, and B/C ratio. The channel length a suggestion would be to improve the high price disparities that can be detrimental to farmers and consumers, high disparity rice commodity experienced a 132%, the ratio of red chili commodity farmers gain the highest 45.31%. Farmer share highest commodity of red chilli 89 % . In order to regulate the food commodity trade in North Sumatera, the following policies are needed : 1) to provide guidance and assistance to farmers for the empowerment of farmer groups; 2) development of production and market information system and the law on food commodity trading to maintain price stability; 3) improve coordination and synergy of farmers and enterprises to handle production, post-harvest, marketing and credit development of food commodity development .
Gradient High Performance Liquid Chromatography method for determination of related substances in (7-{4-[4-(1-Benzothiophen-4-YL] Butoxy} Quinolin-2(1H)-one) dosage form
Authors: Karuna Kumar B. , Chandra Shekar K.B , Guna Sekaran V. 
Published: February 2019

A sensitive HPLC method was developed and validated for the estimation of related substances in Brexpiprazole in drug Product. The developed method is found to be specific, reproducible, and stability indicating. Kromasil100-5 C18 (150x4.6mm), 5μ column was used and mobile phase consisted of mixture of phosphate buffer of pH5.2 and ACN in gradient program is used at a flow rate of 1.0mL/min at a wave length of 215 nm. The detector linearity was established from concentrations ranging from LOQ-150% of specification level with a correlation co-efficient of 0.999. The method was also validated for specificity, LOD, LOQ, accuracy, robustness, precision. The method is proved to be robust with respect to change in flow rate, pH, organic phase composition and column temperature. The proposed method is found to be sensitive, precise, rapid, reproducible, and offers good column life.
Keywords: RP-HPLC; Stability indicating method; Brexpiprazole; validation.
Critical Review on Ksharaplota and its Therapeutic Aspects
Authors: Shekokar Anantkumar V. , Ukhalkar Vijay P. 
Published: February 2019

Kshara is a very important therapeutic approach of Ayurveda ShalyaTantra with minimal invasion. The utilization of Kshara contributes significantly towards the management of ulcer and wound. Kshara application may be two types Pratisarneeya and Paaneeya. Ksharaplota is one of the Pratisarneeya type parasurgical methods of Ayurveda involving use of Kshara to treat various anorectal disorders. Ksharaplota not only clean wound but also covers it and removes debris. Ksharaplota is safe, economic and easy to use for the management of fistula-in-ano & hemorrhoids, etc. The aim of this review article is to summarize all aspect of Ksharaplota therapy to explore therapy for upcoming researchers.
Keywords: Infected wound, Vrana-Shodhana, Ksharaplota, Dushta Vrana, Alkaline Medicated Gauze.
The Effectiveness of Combined Drug Delivery Systems
Authors: Zhang Zhengwei 
Published: February 2019

Treatment of tumors with nanoparticles and combined drugs tend to turn effective as it can sustain for a longer time in the recipient’s body and also improve the impact. The conjugates that have proven to have high cytotoxicity are suggested in this report. Pegylation is an advanced drug delivery system that maximizes the immunity of the patient and helps in the correct targeting of the affected cells.
Keywords: Tumors, Nanoparticles, Drug targeting
Preliminary phytochemical screening of Iris kashmiriana Baker collected from Budgam, Kashmir, India
Authors: JouFarooqnal Saeema , Mohi-ud-din Roohi , Bhat Zulfiqar Ali 
Published: February 2019

The present study was intended to discover the preliminary phytochemicals of Iris kashmiriana Baker collected from Kashmir region, India. The preliminary phytochemical analysis was conducted in methanolic and aqueous extracts which showed the presence of carbohydrates, tannins, flavonoids, phenols, phytosterols, saponins, diterpenes, cardiac glycosides. Among the various phytochemicals studied, alkaloids and proteins were found to be absent in both methanolic and aqueous extracts. From the results, it was noted that the extracts of Iris kashmiriana Baker was found to be a rich source of variety of active secondary metabolites. This report will lead to the further isolation and characterization of these active secondary metabolites for bioefficacy and bioactivity.
Keywords: Phytochemical, Bioactive compounds, Iris kashmiriana, Mazar mund, Kashmir.
Insulin Resistance and Polycystic ovary Syndrome: A Review
Authors: Maqbool Mudasir , Dar Mohmad Amin , Gani Imran , Geer Mohammad Ishaq 
Published: February 2019

Polycystic Ovary Syndrome (PCOS) is the most common, yet complex, endocrine disorder affecting women in their reproductive years and is a leading cause of infertility. This disease appears to be multifactorial and polygenic in nature involving multisystem dysfunction, namely reproduction, endocrine and metabolic. Hyperandrogenism and insulin resistance appear to be central cause to the pathophysiology of the disease. The glucose and insulin metabolism pathways have been studied and debated to understand whether Insulin Resistance is due to a defect in insulin action or a primary defect in β-cell function or decreased hepatic clearance of insulin, or a combination of all these factors. Numerous studies have demonstrated that obese, normal weight and thin women with PCOS have a form of insulin resistance that is unique and intrinsic to the disorder. Moreover obese women with PCOS possess an additional burden of insulin resistance resulting from their excess adiposity. Hyperinsulinemia leads to increase in androgen production directly by acting as a co-gonadotropin, augmenting Luteinizing Hormone activity within the ovary, and indirectly by increasing serum LH pulse amplitude. Whereas Androgens may in turn contribute at least partially to the insulin resistance state linked with PCOS. In this review, we will briefly study the role of insulin resistance in polycystic ovary syndrome.
Keywords: Polycystic ovary syndrome, insulin resistance, Hyperandrogenism.
Ecofriendly synthesis of silver nanoparticles from leaves extract of Phyllanthus niruri (L.) and their antibacterial properties
Authors: Amalorpavamary G , Dineshkumar G , Jayaseelan K 
Published: February 2019

In recent times, plant-mediated synthesis of nanoparticles has garnered wide interest owing to its inherent features such as rapidity, simplicity, eco-friendliness and cheaper costs. For the first time, silver nanoparticles were successfully synthesized using Phyllanthus niruri leaf extract in the current investigation. The silver nanoparticles were characterized by UV–Vis spectrophotometer and the characteristic surface plasmon resonance peak was identified to be 423 nm. The morphology of the silver nanoparticles was characterized by scanning electron microscopy (SEM). The size of the silver nanoparticles was found to be 10-50 nm, with an average size 15 nm. FTIR analysis was done to identify the functional groups responsible for the synthesis of the AgNPs. The antibacterial potential of synthesized AgNPs was compared with that of aqueous extracts of P.niruri by well diffusion method. The AgNPs at 50µl concentration significantly inhibited bacterial growth against A.hydrophila (16 ± 0.09 mm). Thus AgNPs showed broad spectrum antibacterial activity at lower concentration and may be a good alternative therapeutic approach in future.
Keywords: Phyllanthus niruri, AgNps, Aeromonas hydrophila, Antibacterial Activity.
Development and validation of stability indicating UPLC method for the estimation of ticagrelor in bulk and its tablet dosage form
Authors: Omaima J , Shyamala , , Sharma J V C 
Published: February 2019

The objective of the method was to develop a simple, rapid, sensitive, precise, accurate and validated Ultra Performance Liquid Chromatographic (UPLC) method for the estimation of Ticagrelor in tablet dosage form. Chromatographic separation was achieved on an acquity UPLC BDS C8 (150 x 4.6 mm, 5m) column with a mobile phase composed of Buffer 0.1% OPA (2.2 pH) and Acetonitrile in the ratio of 60:40 at a flow rate of 1.0 ml/min and 1 μl injection volume. The effluents were detected at a wavelength of 240 nm using TUV detector. The retention time of Ticagrelor was found to be at 0.942 min. %RSD of the Ticagrelor was found to be 0.7 The method was validated with respect to specificity, accuracy, linearity, precision, robustness. The correlation coefficient for Ticagrelor was found to be 0.999. Recovery of Ticagrelor in formulation was found to be 99.51% . LOD, LOQ values obtained from regression equations of Ticagrelor were 0.45, 1.35 respectively. Due to simplicity, high precision and rapidness the method can be successfully applied for estimation of Ticagrelor in tablet dosage form.
Keywords: Ultra Performance Liquid Chromatographic, Ticagrelor, Tablet dosage form.
Formulation and evaluation of matrix transdermal patches of meloxicam
Authors: Chourasia Sumit , Shukla Tripti , Dangi Surendra , Upmanyu Neeraj , Jain Nidhi 
Published: February 2019

The present study deals with the formulation and evaluation of transdermalpatches of meloxicam towards enhance its permeation through the skin and maintain the plasma levelconcentration. Transdermal patches were prepared by using polymers like Chitosan, HPMC 15cps and EC 20cpsat various concentrations by solvent casting technique employing dibutyl phthalate as plasticizer and isopropylmyristate as permeation enhancer. The transdermal patches were evaluated for their physico-chemical properties and in-vitro drug release. The transdermal patches were found to be transparent and smooth in texture. Amongthe formulations studied, at the end of 12th hour, the minimum and maximum in-vitro drug release was observedfor the formulations F12 and F4i.e. 80.012 ± 2.012 % and 98.365±3.012%. The mechanism of drugrelease was found to be Non-Fickian diffusion controlled. FT-IR studies revealed theintegrity of the drug in theformulations.
Keywords: Transdermal Patches, Meloxicam, Chitosan, HPMC 15cps, EC 20 cps, in-vitro diffusion studies.