bluuebunny/crossref_metadata_2025_split huggingface dataset:
HUBUNGAN PENGETAHUAN IBU TENTANG KECERDASAN ANAK GOLDEN PERIOD DENGAN SIKAP IBU DALAM MENSTIMULASI KECERDASAN ANAK GOLDEN PERIOD(Di Posyandu Lingkungan Gondang Legi Kecamatan Sutojayan Kab. Blitar)
Authors: Komariyah Siti , Puspitasari Betristasia 
Published: September 2019

Anak merupakan makhluk yang membutuhkan pemeliharaan, pemantauan, kasih sayang dalam tahap pertumbuhan dan perkembangannya. Anak tentu memerlukan nutrisi, stimulasi, pola pengasuhan yang tepat agar masa golden period (0-5 tahun) anak dapat tumbuh dan berkembang secara optimal. Tujuan penelitian mengetahui hubungan antara pengetahuan ibu tentang kecerdasan anak golden period dengan sikap ibu dalam menstimulasi kecerdasan anak golden period.
Desain penelitian yang digunakan adalah korelasi dengan pendekatan cross sectional. Populasinya yaitu ibu yang mempunyai anak balita di posyandu lingkungan Gondang Legi sejumlah 40 responden dengan teknik pengambilan sampel total sampling, sehingga semua sampel diuji menggunakan 2 variabel. Variabel independen yaitu pengetahuan ibu tentang kecerdasan anak golden period, variabel dependen yaitu sikap ibu dalam menstimulasi kecerdasan anak golden period. Pengumpulan data kedua variabel menggunakan kuesioner, selanjutnya dilakukan pengolahan data dengan Editing, Coding, Skoring, Tabulating. Teknik analisa yang digunakan untuk menguji hipotesa adalah Chi Kuadrat dengan a = 0,05.
Hasil penelitian diperoleh pengetahuan responden tentang kecerdasan anak golden period adalah cukup 26 responden (65%) dan sikap dalam menstimulasi kecerdasan anak golden period negatif sebanyak 23 responden (57,5%). Uji statistik Chi Kuadrat didapatkan t hitung lebih besar daripada t tabel (harga 7,45> 5,59) maka H1 diterima.
Dari hasil penelitian dapat disimpulkan ada hubungan pengetahuan ibu tentang kecerdasan anak golden period dengan sikap ibu dalam menstimulasi kecerdasan anak golden period di posyandu Lingkungan Gondang Legi Kecamatan Sutojayan Kabupaten Blitar. Diharapkan kepada pihak tenaga kesehatan lebih meningkatkan penyuluhan tentang kecerdasan anak golden period, dan lebih memberikan perhatian dan pengawasan pada anaknya.

Kata Kunci : , Ibu, , Sikap,Stimulasi
PERILAKU SEKSUAL PADA USIA MENOPAUSE DI POSYANDU LANSIA DAHLIA RW 9 KELURAHAN DANDANGAN (Kecamatan Kota Kediri)
Authors: ISTIGHOSAH NINING 
Published: September 2019

Menopause merupakan berhentinya siklus menstruasi wanita yang sering dikaitkan dengan berbagai gejala yang tidak menyenangkan, seperti : kecemasan, depresi, penurunan libido, kekeringan vagina, insomnia, sulit berkonsentrasi, dan gejala vasomotor (hot flashes dan berkeringat di malam hari). Sarrel dalam literaturnya menjelaskan lima perubahan dasar fungsi seksual terkait menopause, penurunan responsivitas seksual, nyeri pada saat berhubungan, penurunan aktifitas seksual, penurunan hasrat seksual, dan adanya pasangan dengan masalah – masalah seksual. Ia melaporkan bahwa gairah seksual, termasuk persepsi sensoris, pelepasan saraf pusat dan perifer, aliran darah perifer dan kapasitas membuat tegangan otot, minat aktifitas seksual dapat dipengaruhi oleh kadar hormone ovarium.
Penelitian ini menggunakan metode deskriptif. Subjek penelitian ini adalah wanita menopause yang berjumlah 10 orang di Posyandu Lansia Dahlia RW 9 Kelurahan Dandangan ( Kecamatan Kota. Kota Kediri ) yang memenuhi kriteria inklusi.
Hasil penelitian ini didapatkan perilaku positif seksual pada usia menopause didapatkan sebanyak 4 responden ( 40%) Sedangkan perilaku negatif seksual pada usia menopause didapatkan sebanyak 6 responden ( 60%).
Simpulan dari penelitian ini menyebutkan bahwa usia menopause memengaruhi perilaku seksual wanita menopause yang tinggal di wilayah posyandu Lansia Dahlia RW 9 Kelurahan Dandangan ( Kecamatan Kota. Kota Kediri )
Perbedaan Masa Perkembangan Anak Prasekolah Usia 48-60 Bulan Berdasarkan Jenis Kelamin Dengan Menggunakan Instrumen Kuesioner Pra Skrining Perkembangan (KPSP) Di TK Dharma Wanita, Desa Tanggulkundung, Kecamatan Besuki, Kabupaten Tulungagung
Authors: Herdyana Erma 
Published: September 2019

Abstrak: Periode penting dalam tumbuh kembang anak adalah pada masa balita. Pertumbuhan dasar yang mempengaruhi dan menentukan perkembangan anak. Masa ini disebut juga periode emas (golden age). Keterlambatan yang dialami anak bisa pada satu atau beberapa ranah perkembangan, atau disebut dengan istilah keterlambatan perkembangan umum atau global development delay bila ditemukan dua atau lebih ranah perkembangan. Menurut Medis 2013, terdapat 5 hingga 10% anak dengan keterlambatan perkembangan dan 1-3% anak dibawah usia 5 tahun dengan keterlambatan perkembangan umum. Penelitian ini menggunakan Deskriptif dengan pendekatan Cross Sectional. Penelitian ini dilaksanakan pada bulan Maret dan April 2019. Populasi dan Sampel dalam penelitian ini adalah 18 anak usia 48-60 bulan di TK Dharma Wanita, Desa Tanggulkundung, Kecamatan Besuki, Kabupaten Tulungagung. Analisis data menggunakan Independent T-test. Hasil penelitan menunjukkan karakteristik usia anak sebagian besar berusia 54-59 bulan dengan presentasi 61,11%. Didapatkan karakteristik responden berdasarkan jenis kelamin sebagian besar Perempuan dengan prosentase 61% dan Laki-laki sebesar 39%. Rata-rata perkembangan anak usia 48-60 bulan dengan kriteria Normal, sedangkan rata-rata masa perkembangan anak dengan jenis kelamin perempuan 99,82% Normal dan 18% dengan kriteria Meragukan, sedangkan rata-masa perkembangan laki-laki yaitu 100% dengan kriteria Normal. Setelah dilakukan uji statistik menggunakan Independent T-Test nilai signifikansi (p) sebesar 0.043<0,05. Ada perbedaan antara masa perkembangan anak dengan jenis kelamin perempuan dan laki-laki.
Hubungan Antara Kadar Homosistein Serum Fase Akut dengan Kemandirian Fungsional Jangka Pendek Pasien Stroke Iskemik
Authors: Widyayanto Isnawan 
Published: September 2019

Latar belakang : Hiperhomosisteinemia merupakan faktor resiko stroke yang dapat dimodifikasi, namun apakah homosistein (Hcy) fase akut salah satu faktor yang mempengaruhi keparahan dan prognosis stroke iskemik masih kontroversi. Penelitian ini bertujuan untuk menilai hubungan antara kadar homosistein serum fase akut dengan kemandirian fungsional stroke iskemik jangka pendek. Metode : Penelitian ini menggunakan rancangan belah lintang, melibatkan 30 pasien stroke iskemik yang dirawat inap di RS. Dr. Kariadi dalam 48 jam sejak onset. Homosistein serum diperiksa dalam kurun 72 jam setelah onset gejala. Kadar homosistein dikategorikan menjadi dua, homosistein tinggi (Hcy>15 ¼mol/l) dan homosistein normal (Hcy<15 ¼mol/l). Keluaran 4 minggu setelah onset dinilai menggunakan Barthel Index (BI). Skor BI ditetapkan mandiri bila skor >95 dan tidak mandiri bila skor <95. Hasil : Sebanyak 30 pasien, 18 (60,0%) laki-laki dan 12 (40,0%) perempuan dengan rerata usia 60,40 ± 7,71 tahun dievalusi. Rerata Hcy puasa semua pasien adalah 14,74 Â± 5,47 Î¼mol/L. Empat belas pasien (46,7%) memiliki Hcy tinggi (Hcy >15 ¼mol/L). Rerata Hcy pada subjek yang masuk kategori Hcy tinggi adalah 19,46 ± 3,71 ¼mol/L dan rerata pada subjek dengan Hcy normal adalah 10,61 ± 7,10 ¼mol/L. Rerata BI pada subjek dengan hiperhomosisteinemia adalah 86,79 ± 12,03 dan rerata BI pada subjek dengan kadar homosistein normal adalah 86,88 ± 14,36. Hasil uji Chi-Square menunjukkan tidak terdapat hubungan antara kadar Hcy dengan nilai Barthel Index (BI) (p=0,464). Simpulan : Kadar homosistein fase akut stroke iskemik tidak berhubungan dengan kemandirian fungsional stroke iskemik jangka pendek (4 minggu).
Pratique musicale et destin du fantasme
Authors: Vinot Frédéric 
Published: September 2019

La pratique musicale, comme pratique instrumentale, est souvent oubliée dans les rares écrits psychanalytiques s’intéressant à la musique, ces derniers privilégiant volontiers l’œuvre ou sa réception. Ce texte propose une approche de la dimension inconsciente de l’instrument de musique sur deux versants : d’une part il en déploie le rôle dans le fantasme inconscient (la formule « un musicien est battu » est développée à partir d’une traduction du verbe Schlagen utilisé par Freud) et d’autre part il s’interroge sur la possibilité qu’offrirait la pratique musicale de se passer de l’Autre. Deux textes de R. Barthes ( Musica practica et Rasch ) laissent en effet supposer qu’une expérience de coups sans agent soit possible dans la praxis musicale.
Stepwise Evolution of Molecular Nanoaggregates Inside the Pores of a Highly Flexible Metal–Organic Framework
Authors: Balestri Davide , Mazzeo Paolo P. , Carraro Claudia , Demitri Nicola , Pelagatti Paolo , Bacchi Alessia 
Published: September 2019

AbstractThe crystalline sponge method (CSM) is primarily used for structural determination by single‐crystal X‐ray diffraction of a single analyte encapsulated inside a porous MOF. As the host–guest systems often show severe disorder, reliable crystallographic determination is demanding; thus the dynamics of the guest entering and the formation of nanoconfined molecular aggregates has not been in the spotlight. Now, the concept is investigated of the CSM for monitoring the structural evolution of nanoconfined supramolecular aggregates of eugenol guests with displacement of DMF inside the cavities of the flexible MOF, PUM168. The interpretation of the electron density provides a series of unique detailed snapshots depicting the supramolecular guest aggregation, thus showing the tight interplay between the host flexible skeleton and the molecular guests through the DMF‐to‐eugenol exchange process.
The Fe2(NO)2 Diamond Core: A Unique Structural Motif In Non‐Heme Iron–NO Chemistry
Authors: Dong Hai T. , Speelman Amy L. , Kozemchak Claire E. , Sil Debangsu , Krebs Carsten , Lehnert Nicolai 
Published: September 2019

AbstractNon‐heme high‐spin (hs) {FeNO}8 complexes have been proposed as important intermediates towards N2O formation in flavodiiron NO reductases (FNORs). Many hs‐{FeNO}8 complexes disproportionate by forming dinitrosyl iron complexes (DNICs), but the mechanism of this reaction is not understood. While investigating this process, we isolated a new type of non‐heme iron nitrosyl complex that is stabilized by an unexpected spin‐state change. Upon reduction of the hs‐{FeNO}7 complex, [Fe(TPA)(NO)(OTf)](OTf) (1), the N‐O stretching band vanishes, but no sign of DNIC or N2O formation is observed. Instead, the dimer, [Fe2(TPA)2(NO)2](OTf)2 (2) could be isolated and structurally characterized. We propose that 2 is formed from dimerization of the hs‐{FeNO}8 intermediate, followed by a spin state change of the iron centers to low‐spin (ls), and speculate that 2 models intermediates in hs‐{FeNO}8 complexes that precede the disproportionation reaction.
Enhanced Drug Delivery by Dissolution of Amorphous Drug Encapsulated in a Water Unstable Metal–Organic Framework (MOF)
Authors: Suresh Kuthuru , Matzger Adam J. 
Published: September 2019

AbstractEncapsulating a drug molecule into a water‐reactive metal–organic framework (MOF) leads to amorphous drug confined within the nanoscale pores. Rapid release of drug occurs upon hydrolytic decomposition of MOF in dissolution media. Application to improve dissolution and solubility for the hydrophobic small drug molecules curcumin, sulindac, and triamterene is demonstrated. The drug@MOF composites exhibit significantly enhanced dissolution and achieves high supersaturation in simulated gastric and/or phosphate buffer saline media. This combination strategy where MOF inhibits crystallization of the amorphous phase and then releases drug upon MOF irreversible structural collapse represents a novel and generalizable approach for drug delivery of poorly soluble compounds while overcoming the traditional weakness of amorphous drug delivery: physical instability of the amorphous form.
Identification of Key Reversible Intermediates in Self‐Reconstructed Nickel‐Based Hybrid Electrocatalysts for Oxygen Evolution
Authors: Huang Jianwen , Li Yaoyao , Zhang Yadong , Rao Gaofeng , Wu Chunyang , Hu Yin , Wang Xianfu , Lu Ruifeng , Li Yanrong , Xiong Jie 
Published: September 2019

AbstractThe oxygen evolution reaction (OER) has been explored extensively for reliable hydrogen supply to boost the energy conversion efficiency. The superior OER performance of newly developed non‐noble metal electrocatalysts has concealed the identification of the real active species of the catalysts. Now, the critical active phase in nickel‐based materials (represented by NiNPS) was directly identified by observing the dynamic surface reconstruction during the harsh OER process via combining in situ Raman tracking and ex situ microscopy and spectroscopy analyses. The irreversible phase transformation from NiNPS to α‐Ni(OH)2 and reversible phase transition between α‐Ni(OH)2 and γ‐NiOOH prior to OER demonstrate γ‐NiOOH as the key active species for OER. The hybrid catalyst exhibits 48‐fold enhanced catalytic current at 300 mV and remarkably reduced Tafel slope to 46 mV dec−1, indicating the greatly accelerated catalytic kinetics after surface evolution.
A‐site Cation Engineering for Highly Efficient MAPbI3 Single‐Crystal X‐ray Detector
Authors: Huang Yanmin , Qiao Lu , Jiang Yuanzhi , He Tingwei , Long Run , Yang Fan , Wang Lin , Lei Xiaojuan , Yuan Mingjian , Chen Jun 
Published: September 2019

AbstractMetal halide perovskites have emerged as a new generation of X‐ray detector materials. However, large‐sized MAPbI3 single crystals (SCs) still exhibit lower performance than MAPbBr3 SCs in X‐ray detection. DFT (density functional theory) simulations suggest the problem could be overcome by alloying large‐sized cations at the A site. The alloyed process could notably decrease the electron–phonon coupling strength and increase the material defect formation energy. Accordingly, centimeter‐sized alloyed DMAMAPbI3 (DMA=dimethylammonium) and GAMAPbI3 (GA=guanidinium) SCs are obtained. Electrical characterizations confirm the GAMAPbI3 SCs display improved charge collection efficiency. It also exhibits a remarkable reduction of dark current, an important figure of merit for X‐ray detectors. With a judiciously designed device architecture, the overall detector performance confirms GAMAPbI3 SCs as one of the most sensitive perovskite X‐ray detectors to date.
The Evolving Role of Professional Societies in International Collaboration: Partners for Progress and Prosperity
Authors: Wu Marinda Li 
Published: September 2019

AbstractThe chemistry enterprise is evolving, becoming increasingly multidisciplinary and global. The roles of societies that support the chemistry profession must also evolve and adapt. Traditional roles for professional societies have included sharing research, providing access to information and technologies, and supporting education excellence. Global challenges now provide sister international societies with opportunities to collaborate on: 1) improving the public image of chemistry, 2) identifying and supporting global job opportunities as markets shift, and 3) promoting diversity and inclusion to accelerate progress. Moreover, societies can work together to foster sustainable development by tackling grand challenges to provide clean water, affordable energy, zero hunger, and much more. Sister society collaboration on such challenges, as reflected in the United Nations Sustainable Development Goals, is the basis for the American Chemical Society's new Chemistry Enterprise Partnerships. Professional societies can truly help transform our world by partnering for progress and prosperity.
Dihalomethanes as Bent Bifunctional XB/XB‐Donating Building Blocks for Construction of Metal‐involving Halogen Bonded Hexagons
Authors: Kashina Maria V. , Kinzhalov Mikhail A. , Smirnov Andrey S. , Ivanov Daniil M. , Novikov Alexander S. , Kukushkin Vadim Yu. 
Published: September 2019

AbstractThe dihalomethanes CH2X2 (X=Cl, Br, I) were co‐crystallized with the isocyanide complexes trans‐[MXM2(CNC6H4‐4‐XC)2] (M=Pd, Pt; XM=Br, I; XC=F, Cl, Br) to give an extended series comprising 15 X‐ray structures of isostructural adducts featuring 1D metal‐involving hexagon‐like arrays. In these structures, CH2X2 behave as bent bifunctional XB/XB‐donating building blocks, whereas trans‐[MXM2(CNC6H4‐4‐XC)2] act as a linear XB/XB acceptors. Results of DFT calculations indicate that all XCH2–X⋅⋅⋅XM–M contacts are typical noncovalent interactions with estimated strengths in the range of 1.3–3.2 kcal mol−1. A CCDC search reveals that hexagon‐like arrays are rather common but previously overlooked structural motives for adducts of trans‐bis(halide) complexes and halomethanes.
Design and Applications of Small Molecular Probes for Calcium Detection
Authors: Roopa  , Kumar Naresh , Kumar Manoj , Bhalla Vandana 
Published: September 2019

AbstractThe physiological significance of calcium ions such as the role in cellular signalling, cell growth, etc. have driven the development of methods to detect and monitor the level of Ca2+ ions, both in vivo and in vitro. Although various approaches for the detection of calcium ions have been reported, methods based on small molecular fluorescent probes have unique advantages including small probe size, easy monitoring of detection processes and applicability in biological systems. In this review article, we will discuss the progress in the development of Ca2+‐binding fluorescent probes by taking into account the types of chelating groups that have been employed for Ca2+ binding.
Re‐Investigation of Hydration Potential of Rhodococcus Whole‐Cell Biocatalysts towards Michael Acceptors
Authors: Busch Hanna , Alvarenga Natália , Abdelraheem Eman , Hoek Max , Hagedoorn Peter‐Leon , Hanefeld Ulf 
Published: September 2019

AbstractThe implementation of a stereoselective Michael addition with water as substrate is still a major challenge by classical, chemical means. Inspired by nature's ability to carry out this attractive reaction with both high selectivity and efficiency, the interest in hydratases (EC 4.2.1.x) to accomplish a selective water addition is steadily rising. The gram‐positive bacterial genus Rhodococcus is known as biocatalytic powerhouse and has been reported to hydrate various Michael acceptors leading to chiral alcohols. This study aimed at the in‐depth re‐investigation of the hydration potential of Rhodococcus whole‐cells towards Michael acceptors. Here, two concurrent effects responsible for the hydration reaction were found: while the majority of substrates was hydrated in an oxygen‐independent manner by amino‐acid catalysis, an enzyme‐catalysed water addition to (E)‐4‐hydroxy‐3‐methylbut‐2‐enoic acid was proven to be oxygen‐dependent. 18O2‐labelling studies showed that no 18O2 was incorporated in the product. Therefore, a novel O2‐dependent hydratase distinct from all characterised hydratases so far was found.
Synthesis and Cellular Labeling of Caged Phosphatidylinositol Derivatives
Authors: Müller Rainer , Citir Mevlut , Hauke Sebastian , Schultz Carsten 
Published: September 2019

AbstractPhosphatidylinositol (PI) is the biosynthetic precursor for seven phosphoinositides, important signaling lipids in cells. A membrane‐permeant caged PI derivative featuring a photo‐removable coumarinyl group masking the negative charge of the phosphate, as well as two enzymatically removable butyrate esters for increased lipophilicity and for preventing phosphate migration, were synthesized. Rapid cell entry and cellular labeling in fixed cells was demonstrated by a photo‐cross‐linkable diazirine followed by attachment of a fluorophore through click chemistry. Using this technique, we found that the multifunctional caged PI derivative resided predominantly at internal membranes but rapidly changed to the plasma membrane after uncaging. Accordingly, a preliminary proteomic analysis of the lipid–protein conjugates revealed that the two major PI transport proteins PITPα and β were prime targets of the photo‐cross‐linked PI derivative.
NMR Spectroscopy–Based Metabolic Profiling of Biospecimens
Authors: Sengupta Arjun , Weljie Aalim M. 
Published: September 2019

AbstractMetabolomics refers to study of metabolites in biospecimens such as blood serum, tissues, and urine. Nuclear magnetic resonance (NMR) spectroscopy and ultra‐performance liquid chromatography–tandem mass spectrometry (UPLC‐MS/MS; mass spectrometry coupled with liquid chromatography) are most frequently employed to analyze complex biological/clinical samples. NMR is a relatively insensitive tool compared to UPLC‐MS/MS but offers straightforward quantification and identification and easy sample processing. One‐dimensional 1H NMR spectroscopy is inherently quantitative and can be readily used for metabolite quantification without individual metabolite standards. Two‐dimensional spectroscopy is most commonly used for identification of metabolites but can also be used quantitatively. Although NMR experiments are unbiased regarding the chemical nature of the analyte, it is crucial to adhere to the proper metabolite extraction protocol for optimum results. Selection and implementation of appropriate NMR pulse programs are also important. Finally, employment of the correct metabolite quantification strategy is crucial as well. In this unit, step‐by‐step guidance for running an NMR metabolomics experiment from typical biospecimens is presented. The unit describes an optimized metabolite extraction protocol, followed by implementation of NMR experiments and quantification strategies using the so‐called “targeted profiling” technique. This approach relies on an underlying basis set of metabolite spectra acquired under similar conditions. Some strategies for statistical analysis of the data are also presented. Overall, this set of protocols should serve as a guide for anyone who wishes to enter the world of NMR‐based metabolomics analysis. © 2019 by John Wiley & Sons, Inc.Basic Protocol 1: Metabolite extraction from different biospecimensBasic Protocol 2: Preparation of dried upper fraction for NMR analysisAlternate Protocol: Preparation of urine samples for NMR analysisBasic Protocol 3: NMR experimentsBasic Protocol 4: Spectral processing and quantification of metabolitesBasic Protocol 5: Statistical analysis of the data
miR‐218 regulates diabetic nephropathy via targeting IKK‐β and modulating NK‐κB‐mediated inflammation
Authors: Li Mo , Guo Qiushi , Cai Hanqing , Wang Haiyang , Ma Zhiming , Zhang Xuan 
Published: September 2019

AbstractDiabetic nephropathy (DN) is a common clinically relevant complication of diabetes that is associated with damage to the capillaries, yet the etiology of this condition remains unclear. Nuclear factor‐kappa B (NF‐κB) activation is known to be associated with DN‐related inflammation and disease progression. Recent work indicated that microRNAs are diagnostic biomarkers of DN progression associated with inﬂammation in the progression of DN. miR‐218 is known to play key regulatory roles in certain cancers in humans, while its influence on DN pathology remains uncertain. The present study, therefore, sought to assess how miR‐218 influences the progression of disease in both a rat streptozotocin‐induced model of DN and as well as an in vitro model system in which mouse podocytes were stimulated with high glucose levels. We found miR‐218 to be markedly downregulated in both model systems relative to appropriate controls, and this downregulation was associated with IKK‐β upregulation. In DN rat model, overexpressing miR‐218 was sufficient to reduce renal injury. We further determined that podocyte proliferation was markedly impaired by glucose treatment, leading to the apoptotic death of these cells, and miR‐218 mimics were able to reduce these phenotypes. Overexpressing miR‐218 also significantly dampened inflammatory responses in this model system, as evidenced by reduced tumor necrosis factor‐α, interleukin‐6 (IL‐6), IL‐1β, and MCP‐1 levels. We then confirmed that miR‐218 targeting the messenger RNA encoding IKK‐β using a dual‐luciferase reporter assay. Together, our results provide clear evidence that miR‐218 regulate NF‐κB‐mediated inflammation, which is central to DN progression.