bluuebunny/crossref_metadata_2025_split huggingface dataset:
Highly enhanced thermoelectric performance in BiCuSeO ceramics realized by Pb doping and introducing Cu deficiencies
Authors: Chen Yue‐Xing , Shi Kang-Di , Li Fu , Xu Xiao , Ge Zhen-Hua , He Jiaqing 
Published: April 2019

AbstractIn recent years, BiCuSeO oxyselenides have been developed as a promising thermoelectric material. In this article, PbxBi1−xCu1−ySeO (x = y = 0, 0.02, 0.04, 0.06, and 0.08) are prepared by solid‐state reaction method and spark plasma sintering (SPS), and the combinatorial effects of Pb doping and Cu deficiencies on thermoelectric properties are investigated systematically. The transport properties are significantly enhanced due to the optimized carrier density, majorly contributing to the promotion of ZT values. As a result, the maximum ZT of 0.77 at 873 K and average ZT (from 300 to 873 K) of 0.50 are obtained for Pb0.06Bi0.94Cu0.94SeO sample. The values are 0.4 and 1.2 times, respectively, higher than that of pristine sample.
In search of meaning: Lessons, resources and next steps for computational analysis of financial discourse
Authors: El‐Haj Mahmoud , Rayson Paul , Walker Martin , Young Steven , Simaki Vasiliki 
Published: April 2019

AbstractWe critically assess mainstream accounting and finance research applying methods from computational linguistics (CL) to study financial discourse. We also review common themes and innovations in the literature and assess the incremental contributions of studies applying CL methods over manual content analysis. Key conclusions emerging from our analysis are: (a) accounting and finance research is behind the curve in terms of CL methods generally and word sense disambiguation in particular; (b) implementation issues mean the proposed benefits of CL are often less pronounced than proponents suggest; (c) structural issues limit practical relevance; and (d) CL methods and high quality manual analysis represent complementary approaches to analyzing financial discourse. We describe four CL tools that have yet to gain traction in mainstream AF research but which we believe offer promising ways to enhance the study of meaning in financial discourse. The four tools are named entity recognition (NER), summarization, semantics and corpus linguistics.
Detailed genetic analysis of feeding behaviour in Romane lambs and links with residual feed intake
Authors: Marie‐Etancelin Christel , Francois Dominique , Weisbecker Jean‐Louis , Marcon Didier , Moreno‐Romieux Carole , Bouvier Frédéric , Tortereau Flavie 
Published: April 2019

AbstractBreeding strategies based on feed efficiency are now implemented in most animal species using residual feed intake (RFI) criteria. Although relevant, the correlated responses of feeding behaviour traits resulting from such selection on RFI are poorly documented. We report the estimated feeding behaviour at three time levels (visit, meal and day) and genetic parameters between the feeding behaviour traits and their links with RFI and its components. Feed intake, feeding duration at three time levels (per visit, meal and day), feeding rate, number of visits and time‐between‐visits were estimated for 951 Romane lambs fed via automatic concentrate feeders. Heritability estimates of feeding behaviour traits ranged from 0.19 to 0.54 with higher estimates for the day level than the visit level. Daily feed intake was not genetically linked to feed intake at the visit level, whereas feeding duration between visit and day levels was moderately correlated (Rg = +0.41 ± 0.12). RFI was not significantly correlated with feeding rate, but was positively linked to feed intake and feeding duration at the day level (+0.73 ± 0.09 and +0.41 ± 0.13, respectively) and negatively at the visit level (−0.33 ± 0.14 and −0.22 ± 0.17, respectively). Selecting animals with lower RFI values might modify their feeding behaviour by increasing feed intake and feeding duration at the visit level but decrease the number of visits per day (+0.51 ± 0.14).
Nerve sprouting and neurogenic inflammation characterize the neurogenic detrusor overactive bladder of patients no longer responsive to drug therapies
Authors: Traini Chiara , Del Popolo Giulio , Faussone‐Pellegrini Maria‐Simonetta , Guasti Daniele , Catarinicchia Stefano , Vannucchi Maria Giuliana 
Published: April 2019

AbstractUrothelium and Lamina Propria (LP) are considered an integrate sensory system which is able to control the detrusor activity. Complete supra‐sacral spinal cord lesions cause Neurogenic Detrusor Overactivity (NDO) whose main symptoms are urgency and incontinence. NDO therapy at first consists in anti‐muscarinic drugs; secondly, in intra‐vesical injection of botulinum toxin. However, with time, all the patients become insensitive to the drugs and decide for cystoplastic surgery. With the aim to get deeper in both NDO and drug's efficacy lack pathogenesis, we investigated the innervation, muscular and connective changes in NDO bladders after surgery by using morphological and quantitative methodologies. Bladder innervation showed a significant global loss associated with an increase in the nerve endings located in the upper LP where a neurogenic inflammation was also present. Smooth muscle cells (SMC) anomalies and fibrosis were found in the detrusor. The increased innervation in the ULP is suggestive for a sprouting and could condition NDO evolution and drug efficacy length. Denervation might cause the SMC anomalies responsible for the detrusor altered contractile activity and intra‐cellular traffic and favour the appearance of fibrosis. Inflammation might accelerate these damages. From the clinical point of view, an early anti‐inflammatory treatment could positively influence the disease fate.
Reconciling place attachment with catchment‐based flood risk management: What can we learn from film?
Authors: Bark Rosalind H. , Sutherland Paula 
Published: April 2019

AbstractA catchment‐based approach to flood risk management (FRM) is gaining prominence in the United Kingdom. It is undertaken with wider awareness of multiple stakeholders, as part of a catchment scale understanding, and, as with other approaches, can visually re‐shape place. Land cover and land management change at this scale also has the potential to reconfigure landscape values and place attachment. Researchers have used qualitative, quantitative, and mapping approaches to understand place attachment. Here we explore secondary data, specifically, we transcribe and code the stories of five Mytholmroyd, West Yorkshire residents from the short film, Calder about the December 26, 2015 floods. We find place attachment, identity, and social capital are interconnected and feature strongly in the mitigation and prevention phase, post‐disaster. Our findings suggest better understanding of place attachment can support a more catchment scale approach to FRM policy and practice.
Cervical vertebral body growth and emergence of sexual dimorphism: a developmental study using computed tomography
Authors: Miller Courtney A. , Hwang Seong Jae , Cotter Meghan M. , Vorperian Houri K. 
Published: April 2019

AbstractThe size and shape of human cervical vertebral bodies serve as a reference for measurement or treatment planning in multiple disciplines. It is therefore necessary to understand thoroughly the developmental changes in the cervical vertebrae in relation to the changing biomechanical demands on the neck during the first two decades of life. To delineate sex‐specific changes in human cervical vertebral bodies, 23 landmarks were placed in the midsagittal plane to define the boundaries of C2 to C7 in 123 (73 M; 50 F) computed tomography scans from individuals, ages 6 months to 19 years. Size was calculated as the geometric area, from which sex‐specific growth trend, rate, and type for each vertebral body were determined, as well as length measures of local deformation‐based morphometry vectors from the centroid to each landmark. Additionally, for each of the four pubertal‐staged age cohorts, sex‐specific vertebral body wireframes were superimposed using generalized Procrustes analysis to determine sex‐specific changes in form (size and shape) and shape alone. Our findings reveal that C2 was unique in achieving more of its adult size by 5 years, particularly in females. In contrast, C3–C7 had a second period of accelerated growth during puberty. The vertebrae of males and females were significantly different in size, particularly after puberty, when males had larger cervical vertebral bodies. Male growth outpaced female growth around age 10 years and persisted until around age 19–20 years, whereas females completed growth earlier, around age 17–18 years. The greatest shape differences between males and females occurred during puberty. Both sexes had similar growth in the superoinferior height, but males also displayed more growth in anteroposterior depth. Such prominent sex differences in size, shape, and form are likely the result of differences in growth rate and growth duration. Female vertebrae are thus not simply smaller versions of the male vertebrae. Additional research is needed to further quantify growth and help improve age‐ and sex‐specific guidance in clinical practice.
Nerve growth factor is expressed and stored in central neurons of adult zebrafish
Authors: Cacialli Pietro , Gatta Claudia , D'Angelo Livia , Leggieri Adele , Palladino Antonio , de Girolamo Paolo , Pellegrini Elisabeth , Lucini Carla 
Published: April 2019

Abstract
Nerve growth factor (NGF), a member of the neurotrophin family, was initially described as neuronal survival and growth factor, but successively has emerged as an active mediator in many essential functions in the central nervous system of mammals. NGF is synthesized as a precursor pro‐NGF and is cleaved intracellularly into mature NGF. However, recent evidence demonstrates that pro‐NGF is not a simple inactive precursor, but is also secreted outside the cells and can exert multiple roles. Despite the vast literature present in mammals, studies devoted to NGF in the brain of other vertebrate models are scarce. Zebrafish is a teleost fish widely known for developmental genetic studies and is well established as model for translational neuroscience research. Genomic organization of zebrafish and mouse NGF is highly similar, and zebrafish NGF protein has been reported in mature and two‐precursors forms. To add further knowledge on neurotrophic factors in vertebrate brain models, we decided to determine the NGF mRNA and protein distribution in the adult zebrafish brain and to characterize the phenotype of NGF‐positive cells. NGF mRNA was visualized by in situ hybridization on whole‐mount brains. NGF protein distribution was assessed on microtomic sections by using an antiserum against NGF, able to recognize pro‐NGF in adult zebrafish brain as demonstrated also in previous studies. To characterize NGF‐positive cells, anti‐NGF was employed on microtomic slides of aromatase B transgenic zebrafish (where radial glial cells appeared fluorescent) and by means of double‐immunolabeling against NGF/proliferative cell nuclear antigen (PCNA; proliferation marker) and NGF/microtube‐associated protein2 (MAP2; neuronal marker). NGF mRNA and protein were widely distributed in the brain of adult zebrafish, and their pattern of distribution of positive perikaryal was overlapping, both in males and females, with few slight differences. Specifically, the immunoreactivity to the protein was observed in fibers over the entire encephalon. MAP2 immunoreactivity was present in the majority of NGF‐positive cells, throughout the zebrafish brain. PCNA and aromatase B cells were not positive to NGF, but they were closely intermingled with NGF cells. In conclusion, our study demonstrated that mature neurons in the zebrafish brain express NGF mRNA and store pro‐NGF.
Plasma CADM1 promoter hypermethylation and D‐dimer as novel metastasis predictors of cervical cancer
Authors: Rong Guodong , Zhang Meijuan , Xia Wenying , Li Donghua , Miao Juan , Wang Hong 
Published: April 2019

AbstractAimCervical cancer (CC) is the fourth malignant tumor in women worldwide. The metastasis is still the major reason for the treatment failures of most CC patients. Cell adhesion molecule 1 (CADM1) promoter methylation and plasma D‐dimer levels have been reported to be increased in many types of cancers. The purpose of this study was to investigate the value of combinatorial assay of plasma CADM1 promoter hypermethylation and D‐dimer as a metastasis marker in CC.MethodsTwo hundred and ninety‐two patients with newly diagnosed cervical diseases and 70 healthy women were enrolled. A validation set comprised 36 Stage I CC patients and followed for 3 years. Plasma CADM1 promoter methylation and D‐dimer levels were detected.ResultsThe total coincidence rate of CADM1 promoter methylation status was 93.3% between 45 pair‐matched tissue and plasma samples. Plasma CADM1 methylation levels in CC patients were higher than other benign disease groups (P = 0.000). Plasma CADM1 methylation levels had statistically differences between CC patients with and without lymph node metastasis (P = 0.049) or in CC patients with and without distant metastasis (P = 0.000). Similarly, plasma D‐dimer levels in CC patients were higher than other benign disease groups (P < 0.05). D‐dimer levels were only statistically different between CC patients with and without distant metastasis (P = 0.003). Combined assay of the two parameters for metastasis prediction has high sensitivity (80.4%) and specificity (90.5%).ConclusionCombinatorial assay of plasma CADM1 methylation and D‐dimer is a promising metastasis marker in cervical cancer.
Are the Religiously Observant Discriminated Against in the Rental Housing Market? Experimental Evidence from Israel
Authors: Sansani Shahar 
Published: April 2019

AbstractIn this article, I test for discrimination against the religiously observant in the Israeli rental housing market. I perform a correspondence study where half of the requests have a religious signal (“basad” written at the top of the request), while the other half do not. Because the requests are identical otherwise, differences in call‐back rates represent the causal effect of writing “basad” at the top of the request. I find that requests with a religious signal receive 12 percent fewer positive responses than requests with no such signal, with this differential being greater with female landlords and in cities with more left‐leaning voters, higher mean incomes, and higher education levels.
Evidence for shock‐induced anhydrite recrystallization and decomposition at the UNAM‐7 drill core from the Chicxulub impact structure
Authors: Salge T. , Stosnach H. , Rosatelli G. , Hecht L. , Reimold W. U. 
Published: April 2019

AbstractDrill core UNAM‐7, obtained 126 km from the center of the Chicxulub impact structure, outside the crater rim, contains a sequence of 126.2 m suevitic, silicate melt‐rich breccia on top of a silicate melt‐poor breccia with anhydrite megablocks. Total reflection X‐ray fluorescence analysis of altered silicate melt particles of the suevitic breccia shows high concentrations of Br, Sr, Cl, and Cu, which may indicate hydrothermal reaction with sea water. Scanning electron microscopy and energy‐dispersive spectrometry reveal recrystallization of silicate components during annealing by superheated impact melt. At anhydrite clasts, recrystallization is represented by a sequence of comparatively large columnar, euhedral to subhedral anhydrite grains and smaller, polygonal to interlobate grains that progressively annealed deformation features. The presence of voids in anhydrite grains indicates SOx gas release during anhydrite decomposition. The silicate melt‐poor breccia contains carbonate and sulfate particles cemented in a microcrystalline matrix. The matrix is dominated by anhydrite, dolomite, and calcite, with minor celestine and feldspars. Calcite‐dominated inclusions in silicate melt with flow textures between recrystallized anhydrite and silicate melt suggest a former liquid state of these components. Vesicular and spherulitic calcite particles may indicate quenching of carbonate melts in the atmosphere at high cooling rates, and partial decomposition during decompression at postshock conditions. Dolomite particles with a recrystallization sequence of interlobate, polygonal, subhedral to euhedral microstructures may have been formed at a low cooling rate. We conclude that UNAM‐7 provides evidence for solid‐state recrystallization or melting and dissociation of sulfates during the Chicxulub impact event. The lack of anhydrite in the K‐Pg ejecta deposits and rare presence of anhydrite in crater suevites may indicate that sulfates were completely dissociated at high temperature (T > 1465 °C)—whereas ejecta deposited near the outer crater rim experienced postshock conditions that were less effective at dissociation.
Shock‐induced phase transformation of anorthitic plagioclase in the eucrite meteorite Northwest Africa 2650
Authors: Chen De‐Liang , Zhang Ai‐Cheng , Pang Run‐Lian , Chen Jia‐Ni , Li Yang 
Published: April 2019

AbstractAnorthite is an important constituent mineral in basaltic achondrites from small celestial bodies. Its high‐pressure phase transformation in shocked meteorites has not been systematically studied. In this study, we report the diverse phase transformation behaviors of anorthite in a shocked eucrite Northwest Africa (NWA) 2650, which also contains coesite, stishovite, vacancy‐rich clinopyroxene, super‐silicic garnet, and reidite. Anorthite in NWA 2650 has transformed into anorthite glass (anorthite glassy vein, maskelynite, and glass with a schlieren texture and vesicles), tissintite and dissociated into three‐phase assemblage grossular + kyanite + silica glass. Different occurrences of anorthite glass might have formed via the mechanism involving shear melting, solid‐state transformation, and postshock thermally melting, respectively. Tissintite could have crystallized from a high‐pressure plagioclase melt. The nucleation of tissintite might be facilitated by relict pyroxene fragments and the early formed vacancy‐rich clinopyroxene. The three‐phase assemblage grossular, kyanite, and silica glass should have formed from anorthitic melt at high‐pressure and high‐temperature conditions. The presence of maskelynite and reidite probably suggests a minimum peak shock pressure up to 20 GPa, while the other high‐pressure phases indicate that the shock pressure during the crystallization of shock melt veins might vary from >8 GPa to >2 GPa with a heterogeneous temperature distribution.
Entrustable professional activities in health care education: a scoping review
Authors: Shorey Shefaly , Lau Tang Ching , Lau Siew Tiang , Ang Emily 
Published: April 2019

ContextThe shift in medical education from time‐based learning to outcome‐based learning has drawn much attention to entrustable professional activities (EPAs) as an ideal assessment framework to translate competencies into clinical practice. Given the relative novelty of EPAs, this review aims to highlight research gaps and explore and consolidate available evidence pertaining to the development and implementation of EPAs in health care.MethodArksey and O'Malley's scoping review framework was used to present the findings. The authors performed a systematic search of PubMed, Embase, CINAHL, Scopus, MedNar, OpenGrey and ProQuest Dissertation and Theses for English articles published from the inception of each database to May 2018. A manual search of the reference lists of the included studies was conducted and an expert panel was consulted. Two reviewers screened the articles for eligibility using the inclusion criteria. All authors extracted key data and analysed the data descriptively. Thematic analysis was used to categorise the results into themes.ResultsEighty articles were included in the review. All articles were published between 2010 and 2018. Three major themes and eight sub‐themes were generated: (i) development of EPAs (frameworks for EPA development and implementation, identifying core or specialty‐specific EPAs, and EPAs for faculty development), (ii) evaluation of EPAs and EPA entrustment factors (revised curriculum, entrustment decisions for professional activities, and feedback on implemented EPAs and the development process), and (iii) future directions and recommendations for EPAs (implementation of EPAs in undergraduate medical education and specific disciplines, and other criticisms and recommendations for EPAs).ConclusionsEntrustable professional activities are an essential means to translate competencies into observable and measurable clinical practice. However, high‐level evidence‐based research on the efficacy, development and implementation of EPAs for specific target groups (i.e. undergraduates and staff) and geographical regions (i.e. Asia and Africa) is still lacking, which suggests a direction for future research.
Therapeutic strategies in gastroparesis: Results of stepwise approach with diet and prokinetics, Gastric Rest, and PEG‐J: A retrospective analysis
Authors: Strijbos Denise , Keszthelyi Daniel , Smeets Fabiënne G. M. , Kruimel Joanna , Gilissen Lennard P. L. , de Ridder Rogier , Conchillo José M. , Masclee Ad A. M. 
Published: April 2019

AbstractBackgroundGastroparesis is characterized by abnormal gastric motor function with delayed gastric emptying in the absence of mechanical obstruction. In our tertiary referral center, patients are treated with a stepwise approach, starting with dietary advice and prokinetics, followed by three months of nasoduodenal tube feeding with “gastric rest.” When not successful, a percutaneous endoscopic gastrostomy with jejunal extension (PEG‐J) for long‐term enteral feeding is placed.AimTo evaluate the effect of this stepwise approach on weight and symptoms.MethodsAnalyses of data of all referred gastroparesis patients between 2008 and 2016.Key ResultsA total of 86 patients (71% female, 20‐87 years [mean 55.8 years]) were analyzed of whom 50 (58%) had adequate symptom responses to diet and prokinetics. The remaining 36 (decompensated gastroparesis) were treated with three months gastric rest. Symptom response rate was 47% (17/36). Significant weight gain was seen in all patients, independent of symptom response. In the remaining 19 symptom non‐responders, the enteral feeding was continued through PEG‐J. Treatment was effective (symptoms) in 37%, with significant weight gain in all. In 84% of patients, the PEG‐J is still in use (mean duration 962 days).Conclusions and InferencesFollowing a stepwise treatment approach in gastroparesis, adequate symptom response was reached in 86% of all patients. Weight gain was achieved in all patients, independent of symptom response. Diet and prokinetics were effective with regard to symptoms in 58%, temporary gastric rest in 47%, and PEG‐J as third step in 37% of patients.