bluuebunny/crossref_metadata_2025_split huggingface dataset:
Potentides: New Cysteine‐Rich Peptides with Unusual Disulfide Connectivity from Potentilla anserina
Authors: Shen Yuping , Xu Lili , Huang Jiayi , Serra Aida , Yang Huan , Tam James P. 
Published: March 2019

AbstractCysteine‐rich peptides (CRPs), which are disulfide‐constrained peptides with 3 to 5 disulfide bonds and molecular weights of 2 to 6 kDa, are generally hyperstable and resistant to thermal, chemical, and enzymatic degradation. Herein, the discovery and characterization of a novel suite of CRPs, collectively named potentides pA1–pA16 from the root of the medicinal herb Potentilla anserina L, are described. Through a combination of proteomic and transcriptomic methods, it is shown that 35‐residue potentide pA3, which is the most abundant member of potentides, exhibits high stability against heat, acidic, and proteolytic degradation. Transcriptomic analysis revealed that potentide precursor sequences contained four tandem repeats in the mature domain, which is the first report on tandem repeats being found in the Rosaceae family. Disulfide mapping showed that potentide pA3 displayed a novel disulfide connectivity of C1–C3, C2–C6, and C4–C5; a cystine motif that has not been reported in plant CRPs. Transcriptomic data mining and a neighbor‐joining clustering analysis revealed 56 potentide homologues and their distribution in the families of Rosaceae and Ranunculaceae in angiosperm. Altogether, these results reveal a new plant CRP structure with an unusual cystine connectivity. Additionally, this study expands the families and structure diversity of CRPs as potentially active peptide pharmaceuticals.
Two cases of atypical twinning: Phenotypically discordant monozygotic and conjoined twins
Authors: Barnes‐Davis Maria E. , Cortezzo DonnaMaria E. 
Published: March 2019

Key Clinical MessageAtypical twinning highlights that complex mechanisms responsible for twinning are not fully understood and may give further insight into the mechanisms involved. To assume that phenotypic difference is the result of dizygotic twinning would be erroneous and could have significant implications in the care and counseling provided to these patients.
Localized Surface Plasmon Resonance Enhanced Photocatalytic Activity via MoO2/BiOBr Nanohybrids under Visible and NIR light
Authors: Zhang Yi , Sun Kai , Wu Di , Xie Wenjie , Xie Fazhi , Zhao Xiaoli , Wang Xiufang 
Published: March 2019

AbstractDirect efficient employing of solar energy for environmental treatment is obtaining considerable attention at present, where the efficient utilizing the visible (Vis) and near‐infrared (NIR) light is of utmost importance. Herein, the plasmonic MoO2 has been firstly employed to enhance photocatalytic activity in visible and near‐infrared light. By loading MoO2 on BiOBr nanosheets, the plasmonic MoO2/BiOBr photocatalysts have been designed and synthesized through simple hydrothermal method. Localized surface plasmon resonance (LSPR) of MoO2 makes the light absorption range of MoO2/BiOBr extend near‐infrared light. The MoO2/BiOBr nanohybrids display higher photocatalytic performance for rhodamine B (RhB) degradation than that of individual MoO2 and BiOBr under Vis‐ and NIR‐light illumination. About 98 % and 60 % of RhB is degraded in 40 min under >420 nm and >780 nm light illumination. On the one hand, LSPR of MoO2 is beneficial for light absorption and utilization. On the other hand, the synergetic effect between MoO2 and BiOBr facilitates carrier generation, transportation in the interfaces of MoO2 and BiOBr, and reduce carrier recombination. Moreover, the catalytic activity of MoO2/BiOBr nanohybrid almost shows no significant weaken even after five consecutive runs. Our study may open avenues to design the efficient noble metal‐free plasmonic photocatalysts for taking advantage of solar energy efficiently.
3D Starfish‐Like FeOF on Graphene Sheets: Engineered Synthesis and Lithium Storage Performance
Authors: Zhai Jingru , Lei Zhengyu , Sun Kening 
Published: March 2019

AbstractTo address the problems associated with poor conductivity and large volume variation in practical applications as a conversion cathode, engineering of hierarchical nanostructured FeOF coupled with conductive decoration is highly desired, yet rarely reported. Herein, 3D starfish‐like FeOF on reduced graphene oxide sheets (FeOF/rGO) is successfully prepared, for the first time, through a combination of solvothermal reaction, self‐assembly, and thermal reduction. Integrating the structural features of the 3D hierarchical nanostructure, which favorably shorten the path for electron/ion transport and alleviate volumetric changes, with those of graphene wrapping, which can further enhance the electrical conductivity and maintain the structural stability of the electrode, the as‐prepared FeOF/rGO composite exhibits a superior lithium‐storage performance, including a high reversible capacity (424.5 mA h−1 g−1 at 50 mA g−1), excellent stability (0.016 % capacity decay per cycle during 180 cycles), and remarkable rate capability (275.8 mA h−1 g−1 at 2000 mA g−1).
Chasing Multiple Bonding Interactions between Alkaline‐Earth Metals and Main‐Group Fragments
Authors: Wolf Benjamin M. , Anwander Reiner 
Published: March 2019

AbstractFormally dianionic ligands such as alkylidenes or organoimidos play a major role in the organometallic chemistry of transition metals and are an emerging topical area of f‐element chemistry. The pursuit and development of main‐group‐metal congeners has been tackled sporadically but is clearly lacking behind. The pronounced ionic bonding in particular, prevailing in alkali and alkaline‐earth (Ae) metal derivatives, proved cumbersome. Recent substantial progress in the respective field of divalent Ae chemistry has been triggered by the implementation of new synthesis strategies involving new AeII precursors and tailor‐made ligands. The main emphasis of this Minireview will be on the synthesis and reactivity of well‐defined Group 2 alkylidenes, organoimides, silylenes, and phosphandiides.
Effect of Slip‐Stack Self‐Assembly on Aggregation‐Induced Emission and Solid‐State Luminescence in 1,3‐Diarylpropynones
Authors: Sivalingam Soumya , Debsharma Kingshuk , Dasgupta Ayan , Sankararaman Sethuraman , Prasad Edamana 
Published: March 2019

AbstractCo‐facial stacking can result in aggregation‐caused quenching (ACQ) in conjugated organic luminogens. This study provides an attractive ‘slip‐stack’ self‐assembly approach which can eliminate the occurrence of ACQ. The obtained results from steady‐state and time‐resolved optical studies, along with X‐ray diffraction and computational studies demonstrate aggregation‐induced emission enhancement (AIEE) of a donor‐π‐acceptor based 1,3‐diarylpropynone, namely 1‐(naphthalenyl)‐3‐(pyren‐1‐yl)prop‐2‐yn‐1‐one (PYNAP). Unlike the monomer, which exhibits poor photoluminescence in solution (φf=2 % in ACN), the twisted manifold of PYNAP allows the orientation of the molecules in a slip‐stack fashion during the course of aggregation, which not only avoids a direct co‐facial arrangement, but also induces augmented rigidity, leading to restricted intramolecular rotation (RIR) and enhanced emission quantum yield (φf=5 % in ACN/H2O). The aggregation behavior of PYNAP's congener, 1‐phenyl‐3‐(pyren‐1‐yl)prop‐2‐yn‐1‐one (PYPH) reinforces the hypothesis that slip‐stack assembly is a useful strategy for AIEE in polycyclic hydrocarbon luminogens.
Perceptions of a large amount of food based on binge‐eating disorder diagnosis
Authors: Chao Ariana M. , Wadden Thomas A. , Walsh Olivia A. , Gruber Kathryn A. , Alamuddin Naji , Berkowitz Robert I. , Tronieri Jena Shaw 
Published: March 2019

AbstractObjectiveThis study examined what adults with binge‐eating disorder (BED) and obesity perceived as the threshold for a large amount of food and how their evaluations compared to ratings by participants with obesity but without BED.MethodThis was a cross‐sectional study of 150 participants with obesity. BED was assessed using the Questionnaire on Eating and Weight Patterns and confirmed via interview. Participants completed the Eating Patterns Questionnaire and Eating Inventory.ResultsParticipants with BED had significantly higher thresholds for a large amount of food relative to those without BED. Compared to participants without BED, those with BED had significantly higher thresholds on 13 of the 22 food items. In the overall sample, being male and having higher hunger scores were associated with greater thresholds.DiscussionIndividuals with obesity and BED had larger portion standards than participants without BED. Individuals with BED may benefit from interventions targeted toward decreasing perceptions of portion sizes.
Integrating social and ecological data to model metapopulation dynamics in coupled human and natural systems
Authors: Van Schmidt Nathan D. , Kovach Tony , Kilpatrick A. Marm , Oviedo Jose L. , Huntsinger Lynn , Hruska Tracy , Miller Norman L. , Beissinger Steven R. 
Published: March 2019

AbstractUnderstanding how metapopulations persist in dynamic working landscapes requires assessing the behaviors of key actors that change patches as well as intrinsic factors driving turnover. Coupled human and natural systems (CHANS) research uses a multidisciplinary approach to identify the key actors, processes, and feedbacks that drive metapopulation and landscape dynamics. We describe a framework for modeling metapopulations inCHANSthat integrates ecological and social data by coupling stochastic patch occupancy models of metapopulation dynamics with agent‐based models of land‐use change. We then apply this framework to metapopulations of the threatened black rail (Laterallus jamaicensis) and widespread Virginia rail (Rallus limicola) that inhabit patchy, irrigation‐fed wetlands in the rangelands of the California Sierra Nevada foothills. We collected data from five diverse sources (rail occupancy surveys, land‐use change mapping, a survey of landowner decision making, climate and reservoir databases, and mosquito trapping and West Nile virus testing) and integrated them into an agent‐based stochastic patch occupancy model. We used the model to (1) quantify the drivers of metapopulation dynamics, and the potential interactions and feedbacks among them; (2) test predictions of the behavior of metapopulations in dynamic working landscapes; and (3) evaluate the impact of three policy options on metapopulation persistence (irrigation district water cutbacks during drought, incentives for landowners to create wetlands, and incentives for landowners to protect wetlands). Complex metapopulation dynamics emerged when landscapes functioned asCHANS, highlighting the importance of integrating human activities and other ecological processes into metapopulation models. Rail metapopulations were strongly top‐down regulated by precipitation, and the black rail's decade‐long decline was caused by the combination of West Nile virus and drought. Theoretical predictions of the two metapopulations’ responses to dynamic landscapes and incentive programs were complicated by heterogeneity in patch quality andCHANScouplings, respectively. Irrigation cutbacks during drought posed a serious extinction risk that neither incentive policy effectively ameliorated.
Disentangling data discrepancies with integrated population models
Authors: Saunders Sarah P. , Farr Matthew T. , Wright Alexander D. , Bahlai Christie A. , Ribeiro Jose W. , Rossman Sam , Sussman Allison L. , Arnold Todd W. , Zipkin Elise F. 
Published: March 2019

AbstractA common challenge for studying wildlife populations occurs when different survey methods provide inconsistent or incomplete inference on the trend, dynamics, or viability of a population. A potential solution to the challenge of conflicting or piecemeal data relies on the integration of multiple data types into a unified modeling framework, such as integrated population models (IPMs).IPMs are a powerful approach for species that inhabit spatially and seasonally complex environments. We provide guidance on exploiting the capabilities ofIPMs to address inferential discrepancies that stem from spatiotemporal data mismatches. We illustrate this issue with analysis of a migratory species, the American Woodcock (Scolopax minor), in which individual monitoring programs suggest differing population trends. To address this discrepancy, we synthesized several long‐term data sets (1963–2015) within anIPMto estimate continental‐scale population trends, and link dynamic drivers across the full annual cycle and complete extent of the woodcock's geographic range in eastern North America. Our analysis reveals the limiting portions of the life cycle by identifying time periods and regions where vital rates are lowest and most variable, as well as which demographic parameters constitute the main drivers of population change. We conclude by providing recommendations for resolving conflicting population estimates within an integrated modeling approach, and discuss how strategies (e.g., data thinning, expert opinion elicitation) from other disciplines could be incorporated into ecological analyses when attempting to combine multiple, incongruent data types.
Polymer‐MTiO3 (M = Ca, Sr, Ba) composites as facile and scalable supercapacitor separators
Authors: Alvarez‐Sanchez Christian O. , Lasalde‐Ramírez José A. , Ortiz‐Quiles Edwin O. , Massó‐Ferret Roberto , Nicolau Eduardo 
Published: March 2019

AbstractThe quantum of research in the area of supercapacitors is typically focused on the electrode materials. As such, there are many opportunities for the optimization of the other components, such as the separators, to further increase the power, efficiency, and longevity of supercapacitors. To contribute to this field of research, we present an innovative alternative for the fabrication of separators; using polymer/ceramic composites (PCC) based on polyvinylidene fluoride (PVDF) and polypropylene (PPG) mixed with different alkaline earth metal‐based titanates (eg barium, calcium, and strontium). The PCC separators were prepared via phase inversion precipitation technique, a feasible and scalable method for the fabrication of these composites. Different additives were used to modulate the porosity and thus, improve the charge transfer rates. Then, a heating process ensured a uniform organization of the composites. Furthermore, we tested the effect of thermally annealing the ceramics on the separators’ performance. The precursor materials and the PCC's were extensively characterized by means of X‐ray diffraction (XRD) and scanning electron microscopy (SEM). The electrochemical, mechanical, and dielectric properties of the PCC's were measured and compared to common commercial separators used today. Results suggest that thermal treatment improves tensile strength of the separators by at least ca. 60% without compromising the similar electrochemical profile to the commercial separators (44.52 ± 2.82 Ω vs 67.65 ± 29.01 Ω). Lastly, all of the fabricated PCC's showed higher dielectric constants (4.52 in average for the as prepared separators and 2.99 for the heated PCC's) than the polymer based commercial separators (2.2).
Factors associated with obstetric anal sphincter injuries during vacuum delivery among Chinese women
Authors: Chen Sue‐Jar , Chen Chie‐Pein , Sun Fang‐Ju , Chen Chen‐Yu 
Published: March 2019

AbstractObjectiveTo investigate factors associated with obstetric anal sphincter injuries (OASIS) during vacuum delivery among Chinese women.MethodsA retrospective cohort study of Chinese women who underwent vacuum‐assisted vaginal delivery at a tertiary referral hospital in Taiwan between January 2010 and December 2016. Logistic regression analysis was used to compare various factors (maternal, delivery, and neonatal factors) between women with and those without OASIS.ResultsAmong 18 744 Chinese women with singleton vaginal delivery, 3141 (16.76%) had vacuum assistance and 2634 (83.86%) were primiparous. Of the women who had a vacuum delivery, 1073 (34.16%) sustained OASIS, of whom 967 (90.12%) were primiparous. The major independent risk factors for OASIS were primiparity (adjusted odds ratio [aOR], 2.93; 95% confidence interval [CI], 2.29–3.76) and use of midline episiotomy (aOR, 3.01; 95% CI, 1.74–5.17). However, epidural analgesia had a protective effect (aOR, 0.64; 95% CI, 0.54–0.75) against OASIS. In multivariate analysis for the primiparous subgroup, the independent significant risk factors for OASIS remained the same.ConclusionA high incidence of OASIS during vacuum delivery was observed among Chinese women. Midline episiotomy was found to be a modifiable risk factor for OASIS, whereas epidural analgesia had a protective effect.
Association between LINC00657 and miR‐106a serum expression levels and susceptibility to colorectal cancer, adenomatous polyposis, and ulcerative colitis in Egyptian population
Authors: Shaker Olfat G. , Ali Marwa A. , Ahmed Tarek I. , Zaki Othman M. , Ali Doaa Y. , Hassan Essam A. , Hemeda Nada F. , AbdelHafez Marwa N. 
Published: March 2019

AbstractColorectal cancer (CRC) represented the second cause of mortality among cancer patients. Long noncoding RNAs and microRNAs (miRNAs) serve as noninvasive biomarkers for CRC surveillance and introduce new therapeutic approaches. LINC00657 and miR‐106a expression levels play a pivotal role in CRC. This study included 190 Egyptian subjects, and the expression levels of LINC00657 and miR‐106a in serum were measured by using quantitative real‐time polymerase chain reaction. We found that upregulation of LINC00657 and downregulation of miR‐106a are significantly associated with the development of CRC. Also, a positive correlation was detected between their serum levels. In addition, serum LINC00657 can distinguish adenomatous polyposis (AP) patients and/or ulcerative colitis (UC) patients from controls. Also the miRNA‐106a expression level discriminates AP but not UC from healthy individuals. Our study cited new diagnostic biomarkers for CRC, AP, and UC among Egyptians in addition to be noninvasive screening tools for CRC in both healthy subjects and those having precancerous lesions. © 2019 IUBMB Life, 71(9):1322–1335, 2019
Supporting Online Synchronous Collaborative Writing in the Secondary Classroom
Authors: Krishnan Jenell , Yim Soobin , Wolters Alissa , Cusimano Andrew 
Published: March 2019

AbstractOnline synchronous collaborative writing (SCW) is ubiquitous among youths and has found its way into many secondary English language arts classrooms. Yet, to maximize the affordances of online SCW, teachers need a synthesis of contemporary, evidence‐based practices for how to support students during this form of writing. The purpose of this article is to highlight best practices for teachers and schools interested in leveraging their one‐to‐one technologies in more collaborative ways that include online SCW. The authors situate SCW in contemporary educational initiatives and then describe ways that teachers can incorporate SCW in their writing instruction through a hybrid approach—face‐to‐face and online—that enhances rich, meaningful peer‐to‐peer learning. The authors present actionable recommendations for teachers to consider before, during, and after online SCW. The authors conclude with how this approach to writing provides students with the technical and social tools to achieve success in the information society.
COPS5 negatively regulates goat endometrial function via the ERN1 and mTOR‐autophagy pathways during early pregnancy
Authors: Yang Diqi , Zhang Beibei , Wang Zongjie , Zhang Linlin , Chen Huatao , Zhou Dong , Tang Keqiong , Wang Aihua , Lin Pengfei , Jin Yaping 
Published: March 2019

AbstractIn ruminant, adequate endometrial function is a major factor affecting implantation and economic efficiency. However, the precise mechanisms regulating goat endometrial function during the peri‐implantation period of pregnancy are still unclear. Here, we investigated the functional role and signal transduction of the fifth component of the constitutive photomorphogenic‐9 signalosome (COPS5) in the regulation of endometrial function in endometrial epithelial cells (EECs). Our results showed that hormones decreased COPS5 expression, and COPS5‐mediated regulation of endometrial function. We also found that knockdown of COPS5 hindered EECs proliferation by the G1‐phase cell cycle arrest. Hormones affected the activity of COPS5 through hormones receptors, while feedback from the expression of COPS5 regulated the transcription of the receptor. Moreover, knockdown of endoplasmic reticulum (ER) to nucleus signaling 1 (ERN1) via si‐ERN1 partly inhibited endometrial function in shCOPS5 EECs. In addition, blocking the mTOR pathway by rapamycin promoted endometrial function in si‐ERN1‐transfected shCOPS5 EECs. Overall, these results suggest that COPS5 negatively regulates goat endometrial function via the ERN1 and mTOR‐autophagy pathways and provide new insights into the mechanistic pathways of COPS5 during female reproductive development.
Protective effects of microRNA‐22‐3p against retinal pigment epithelial inflammatory damage by targeting NLRP3 inflammasome
Authors: Hu Zizhong , Lv Xuehua , Chen Lu , Gu Xunyi , Qian Huiming , Fransisca Silvia , Zhang Zhengyu , Liu Qinghuai , Xie Ping 
Published: March 2019

AbstractNLRP3, as a crucial inflammasome component, plays important roles in age‐related macular degeneration. Though some activators of NLRP3 have been studied, microRNAs (miRNAs) which potentially regulate NLRP3 messenger RNA (mRNA) have not been fully explored in retinal pigment epithelial (RPE) cells and retinopathy. In this study, by miRNA microarray proﬁling and bioinformatic analysis, we identified that four miRNAs, miR‐4286, miR‐223‐3p, miR‐365a, miR‐22‐3p, may target NLRP3 mRNA in RPE inflammatory damage in vivo. Further, real‐time polymerase chain reaction verified that only miR‐22‐3p was significantly decreased, which was associated with NLRP3 upregulation in blue‐light‐induced retinopathy. Mechanistically, the dual‐fluorescent reporter suggested miR‐22‐3p directly binds NLRP3 mRNA. Moreover, overexpression of miR‐22‐3p could significantly reduce whereas inhibition miR‐22‐3p could increase the mRNA and protein expressions of NLRP3, Caspase‐1, and mature IL‐1β. Collectively, our results indicate that miR‐22‐3p plays a suppressive role in RPE damage by targeting NLRP3, which provides new insights into the future intervention to retinopathy.