bluuebunny/crossref_metadata_2025_split huggingface dataset:
Microwave‐Assisted Fe3O4 Nanoparticles Catalyzed Cascade Synthesis of 3‐(1,4,5‐Triaryl‐1H‐imidazol‐2yl)quinolin‐2‐amines as COX‐1, COX‐2 Inhibitors and Antioxidant Agents
Authors: Bheemayya Lokesh , Kamble Ravindra R. , Shettar Arun K. , Nadoni Vishwa B. , Nayak Manojna R. , Joshi Shrinivas D. , Bayannavar Praveen K. , Metre Tukaram V. , Keri Rangappa S. , Hoskeri Joy H. 
Published: November 2024

ABSTRACTA proficient Fe3O4 nanoparticle catalyzed cascade multicomponent synthetic protocol has been established to synthesize the title compounds. 2‐Chloroquinoline‐3‐carbaldehydes, aniline, and substituted benzils were subjected to cascade coupling to produce novel 3‐(1,4,5‐triaryl‐1H‐imidazol‐2‐yl)quinolin‐2‐amine 5k–z under microwave irradiation using Fe3O4 NPs. According to the biological data and the computational analysis, the compounds were found to bind COX‐2 enzyme superior than the COX‐1 enzyme. The molecular docked positions of the compounds (PDB ID: 4O1Z and PDB ID: 5IKR; A chain) were examined, and the results showed that these configurations are similar to those of the highly selective COX‐1 and COX‐2 inhibitors. Compared to mefenamic acid (1.318 μg), the compounds 5k, 5l, 5n, 5p, 5q, 5r, 5s, 5t, 5v, 5x, and 5z Showed IC50 values of 1.172, 1.136, 1.508, 1.0373, 1.186, 1.017, 1.827, 1.008, 1.504, 1.217, 1.440, and 1.832, respectively, making them the most effective and selective COX‐1 and COX‐2 inhibitors. For every significantly active molecule, a selectivity index was calculated. Interestingly, these molecules that worked as COX inhibitors also functioned well and showed promising results for antioxidant activity.
Synthesis, Structural, DFT, In Vitro Biological Exploration, and DNA Interaction of New Ni(II) and Cu(II) Mixed‐Ligand Complexes Featuring 2,2′‐Pyridine‐2,6‐diylbis(1H‐benzimidazole) and 2‐Hydroxy‐naphthaldehyde‐Based Schiff‐Base
Authors: Abdou Aly 
Published: November 2024

ABSTRACTThis research article provides a comprehensive analysis of the preparation, structural characterization, 3D modeling, and biological screening of two novel formulated metal complexes, NiPDBZNPH and CuPDBZNPH. These complexes were obtained by combining 2,2′‐pyridine‐2,6‐diylbis(1H‐benzimidazole) (PDBZ) and 2‐hydroxy‐naphthaldehyde Schiff‐base (NPH) ligands with Ni(II) and Cu(II) ions, resulting in the compounds [Ni (NPH)(PDBZ)(Cl)] and [Cu (NPH)(PDBZ)(Cl)], respectively. Spectroscopic and analytical techniques confirmed that both complexes exhibit octahedral geometry around the central metal ion. Computational studies using density functional theory (DFT) corroborated the molecular structures and investigated the quantum chemical properties of the ligands and complexes. A series of in vitro assays were conducted to assess their anti‐inflammatory, antifungal, antibacterial, and antioxidant properties, revealing enhanced bioactivity compared to the uncoordinated ligands. The potential of NiPDBZNPH and CuPDBZNPH as therapeutic candidates was also explored through interactions with calf thymus DNA (CT‐DNA). Molecular docking simulations targeting specific protein receptors were performed to evaluate binding affinities and ligand–protein interactions, with results highlighting significant interactions within enzyme active sites. These findings emphasize the pivotal role of metal–ligand coordination in enhancing pharmacological properties and contribute valuable insights toward the design of novel therapeutic compounds for use in medicinal chemistry and pharmaceutical research.
“I wish I could use any language as it comes to mind”: User experience in digital platforms in the context of multilingual personal information management
Authors: Alon Lilach , Krtalić Maja 
Published: November 2024

AbstractIn today's linguistically diverse world, managing personal information across multiple languages presents a challenge. This study engaged 16 multilingual participants to explore their user experience in the context of multilingual personal information management (MPIM), with a focus on inclusivity, universality, and equity. Addressing two main questions, the study explores the challenges users face on digital platforms in MPIM contexts and their ideal platform features. Findings highlight key issues in MPIM platform design, including unsupported languages and integration of visual aesthetics. We also identify user preferences for ideal platform features, such as language flexibility and efficient information retrieval. The study suggests the need for more inclusive, universal, and equitable platform designs that cater to the specific requirements of multilingual users. Ultimately, this study underscores the critical need for improved MPIM support and emphasizes the significance of continued exploration in this area, establishing it as a vital field of future research.
Start Over After Pre‐Empt (SOAP) Protocol
Authors: Sethuraman Jayaram 
Published: November 2024

ABSTRACTConsider a job that normally requires units of time to complete. A higher authority comes and interrupts the service. The inter‐arrival times of the interrupts are , which are the actual available service times to work on the job. Thus, if the first available service time is larger than , the job gets completed, and the remaining service time is the first available service time for the next job. If not, the previous service is lost and service on the job starts from scratch using the next available service time. As before, if , the job gets completed and the remaining service time is the first available service time for the next job. If not, the service is lost, and is the available service time for the job. And so on. Let be the time to complete the job. This is called the start over after pre‐empt (SOAP) protocol. An example of such interrupts is power outages. After a power outage interrupt the partial service on a job running on a computer is lost and service on the job has to start again. We study properties of and , the time to complete two jobs normally requiring times , and give some guidance whether when . We obtain the asymptotic distribution of a stochastic process based on which has interesting independent increments of a new type. My frustrations standing in a queue in India, where a supervisor interrupts and the service on my job has to start again, were my inspiration for the protocol named here as SOAP. A careful referee pointed out that the SOAP protocol is not new in the queues literature. It goes by the name RESTART and has variants called RESUME and REPLACE.
Streamlined Clarification and Capture Process for Monoclonal Antibodies Using Fluidized Bed Centrifugation and Multi‐Column Chromatography With Membrane Adsorbers
Authors: Schmitz Fabian , Saballus Martin , Kruse Thomas , Minceva Mirjana , Kampmann Markus 
Published: November 2024

ABSTRACTHarmonizing unit operations in the downstream process of monoclonal antibodies (mAbs) has a high potential to overcome throughput limitations and reduce manufacturing costs. This study proposes a streamlined clarification and capture (S‐CC) process concept for the continuous processing of cell broth harvested from a connected bioreactor. The process was realized with a fluidized bed centrifuge connected to depth and sterile filters, a surge tank, and a multi‐column chromatography (MCC) unit. The MCC unit was operated in the rapid cycling simulated moving bed (RC‐BioSMB) mode with five convective diffusive membrane adsorbers (MAs). A control strategy and the surge tank were used to adjust the loading flow rate of the MCC unit. The mAb was recovered with a total process yield of 90%, with high removal of the process‐related impurities HCP (2.1 LRV) and DNA (2.9 LRV). Moreover, the S‐CC process productivity of 4.2 g h−1 was up to 5.3 times higher than for comparable, hypothetical batch MA processes. In addition, the buffer consumption of the capture step could be reduced from 2.0 L g−1 in batch mode to 1.2 L g−1 in the RC‐BioSMB mode. These results demonstrate the high potential of streamlined interconnected unit operations to improve the overall mAb downstream process performance.
Regeneration of Spent Culture Media for Sustainable and Continuous mAb Production via Ion Concentration Polarization
Authors: Wynne Eric , Yoon Junghyo , Park Dohyun , Cui Mingyang , Morris Caitlin , Lee Jaeweon , Wang Zhao , Yoon Seongkyu , Han Jongyoon 
Published: November 2024

ABSTRACTIn modern bioprocessing, cell culture media is one of the most significant cost drivers, yet the nutrients and other critical factors in the media are often not fully utilized. With the renewed emphasis on reducing the cost of bioprocessing, there is much interest in reducing the overall use of cell culture media. In this work, we introduce a mesoscale microfluidic separation device based on the ion concentration polarization (ICP) process to regenerate the spent media for reuse by removing critical waste products from the cell culture that are known to inhibit the growth of the cells. We demonstrated that up to 75% of spent culture media can be regenerated and reused without affecting the cell viability. A detailed analysis of the materials consumed during antibody production indicated that one could improve the water process mass intensity by up to 33% by regenerating and recycling the media. Given that ICP separation systems have already been scaled up to support large‐volume processing, it would be feasible to deploy this technology for manufacturing scale bioreactors (e.g., 50 L perfusion culture of CHO cells), reducing the overall operation cost and water use.
Unveiling the blackbox within ESG ratings' blackbox: Toward a framework for analyzing AI adoption and its impacts
Authors: Suárez Giri Felipe , Sánchez Chaparro Teresa 
Published: November 2024

AbstractArtificial intelligence (AI) is transforming entire industries at an unprecedented pace. Yet, established technology adoption theories offer limited tools for characterizing business AI integration and analyzing its effects. These primarily focus on the factors facilitating or hindering adoption, rather than on adoption patterns and impacts. This paper introduces a novel conceptual framework to address this key gap and applies it to the case of the ESG rating industry. ESG raters play a pivotal role in sustainable finance, providing metrics that guide investment decisions globally. However, little is known about the extent and nature of their AI usage and its implications. Through a mixed‐methods approach combining the analysis of job postings, patent filings, research publications, and corporate websites, we examine AI adoption among major ESG raters. Our investigation explores the specific AI technologies employed, their functional applications, the innovations developed, the intensity of AI integration, and the potential impacts of raters' AI adoption. Our results reveal widespread and growing AI adoption across the industry. Our findings show that raters extensively leverage Natural Language Processing to streamline data collection, processing, and analysis. Furthermore, they have pioneered Machine Learning innovations that significantly expand their sustainability assessment capabilities in various domains. These findings mark a considerable departure from prior academic and gray literature that characterized major ESG raters as having minimal AI use, prompting critical questions regarding the implications of this technological transformation for ESG ratings' reliability, transparency, and potential biases.
Empowering Computer Vision in Higher Education: A Novel Tool for Enhancing Video Coding Comprehension
Authors: Cuevas Carlos , Cortés Carlos , García Narciso 
Published: November 2024

ABSTRACTThe growing demand for skilled computer vision professionals requires effective educational approaches. This study explores a novel tool based on Virtual Programming Language principles designed to enhance computer vision education, specifically in video coding. The tool leverages a user‐friendly interface and a custom widget library for video exploration, enabling students to engage with video data manipulation, motion estimation simulations, and visualization of coding effects. A controlled experiment with computer vision students from a university master's program demonstrates that the tool significantly improves student motivation, knowledge acquisition, and overall learning outcomes. This study highlights the potential of such tools to revolutionize computer vision education, leading to better engagement, deeper understanding, and enhanced practical skills. Therefore, it paves the way for further exploration of similar tools in computer vision and other science, technology, engineering, and mathematics disciplines.
Advances in the Understanding of the Pathogenesis of Triple‐Negative Breast Cancer
Authors: Liu Yuhan , Zou Yuhan , Ye Yangli , Chen Yong 
Published: November 2024

ABSTRACTBackgroundTriple‐negative breast cancer (TNBC) is a heterogeneous disease characterized by high aggressiveness, high malignancy, and poor prognosis compared to other breast cancer subtypes.ObjectiveThis review aims to explore recent advances in understanding TNBC and to provide new insights and potential references for clinical treatment.MethodsWe examined current literature on TNBC to analyze molecular subtypes, genetic mutations, signaling pathways, mechanisms of drug resistance, and emerging therapies.ResultsFindings highlight key aspects of TNBC's molecular subtypes, relevant mutations, and pathways, alongside emerging treatments that target drug resistance mechanisms.ConclusionThese insights into TNBC pathogenesis may help guide future therapeutic strategies and improve clinical outcomes for patients with TNBC.
Unveiling CKS2: A Key Player in Aggressive B‐Cell Lymphoma Progression and a Target for Synergistic Therapy
Authors: Zhou Fenling , Chen Lu , Liu Zhen , Cao Yuli , Deng Cuilan , Liu Gexiu , Liu Chengcheng 
Published: November 2024

ABSTRACTBackgroundThe objective of this study was to investigate the expression levels and biological significance of CKS2 in Burkitt cell lymphoma (BL) and diffuse large B‐cell lymphoma (DLBCL). Additionally, the potential synergistic anti‐tumor effects of CKS2 knockdown in combination with etoposide in BL and DLBCL were explored for the first time.MethodsBioinformatics analysis was utilized to explore the transcriptional levels, prognostic value, and gene function enrichment of CKS2 in BL and DLBCL. Specific shRNA sequences were designed to target CKS2 for the purpose of constructing a lentiviral expression vector, and therapeutic effects were assessed through analyses of cell proliferation, cell cycle distribution, and cell apoptosis.ResultsFirst, the study examined the increased transcriptional and protein levels of CKS2 in BL and DLBCL through analysis of various databases and immunohistochemistry tests. Elevated CKS2 expression was found to be correlated with a worse prognosis in BL and DLBCL patients, as evidenced by data from the TCGA and GEO databases. Enrichment analysis indicated that CKS2 functions were primarily linked to protein kinase regulatory activity, G1/S phase transition of the cell cycle, and the p53 signaling pathway, among others. Second, stable suppression of CKS2 gene expression in Raji and SUDHL6 cells using shRNA resulted in a significant inhibition of cell proliferation. Moreover, CKS2‐shRNA induced G0/G1 cell cycle arrest and apoptosis by activating the p53 signaling pathway in Raji and SUDHL6 cells. Third, the combined treatment of CKS2‐shRNA and etoposide exhibited a synergistic effect on the proliferation and apoptosis of Raji and SUDHL6 cells.ConclusionsOur findings suggest that CKS2 may play a critical role in the progression of BL and DLBCL and provide evidence for the potential therapeutic application of combining CKS2‐shRNA and etoposide agents in the treatment of BL and DLBCL.
The Vascular Response After Balloon Angioplasty of Infrapopliteal Intermediate Stenosis Evaluated by Optical Frequency Domain Imaging
Authors: Yamane Haruya , Ueda Yasunori , Ikeoka Kuniyasu , Abe Haruhiko , Inoue Koichi , Matsumura Yasushi 
Published: November 2024

ABSTRACTBackgroundWe often experience worsening of stenosis by balloon angioplasty of infrapopliteal (IP) lesion compared with the initial stenosis. However, reports on this phenomenon are limited.AimsThe main purpose of this study is to evaluate vascular response after balloon angioplasty of IP artery stenosis.MethodsThirteen patients (15 arteries) who underwent endovascular treatment (EVT) and follow‐up angiography with optical frequency domain imaging (OFDI) of intermediate IP stenosis were included. Serial OFDI images at 3 time points (before and after EVT and at follow‐up) were analyzed. Diameter and area of external elastic lamina, internal elastic lamina, and lumen were measured, and plaque area and plaque burden (PB) were calculated. PB before EVT was classified into mild, moderate, and severe by 0%–20%, 21%–40%, and 41%–60%, respectively.ResultsAnalyzed were 229 cross sections. External elastic lamina diameter did not change significantly among three time points (3.8 ± 0.5 [95% confidence interval (CI): 3.7 to 3.9] mm, 3.9 ± 0.4 [95% CI: 3.8 to 4.0] mm, 3.9 ± 0.4 [95% CI: 3.8 to 4.0] mm, p = 0.06). Lumen area increased after EVT but became smaller at follow‐up than before EVT (4.5 ± 1.5 [95% CI: 4.3 to 4.7] mm2, 5.3 ± 1.3 [95% CI: 5.1 to 5.5] mm2, 3.7 ± 1.2 [95% CI: 3.5 to 3.9] mm2, p < 0.001). Plaque area became smaller after EVT and larger at follow‐up than before EVT (3.0 ± 1.7 [95% CI: 2.8 to 3.2] mm2, 2.4 ± 1.5 [95% CI: 2.2 to 2.6] mm2, 4.0 ± 1.6 [95% CI: 3.8 to 4.2] mm2, p < 0.001). Lumen area was significantly smaller at follow‐up than before EVT in mild and moderate PB groups, but it was not different in severe PB group (mild PB group: 5.1 ± 1.5 [95% CI: 4.7 to 5.5] mm2 vs. 4.0 ± 1.3 [95% CI: 3.7 to 4.3] mm2, p < 0.001, moderate PB group: 4.6 ± 1.3 [95% CI: 4.4 to 4.8] mm2 vs. 3.6 ± 1.2 [95% CI: 3.4 to 3.8] mm2, p < 0.001, severe PB group: 3.0 ± 1.4 [95% CI: 2.5 to 3.5] mm2 vs. 3.1 ± 1.0 [95% CI: 2.7 to 3.5] mm2, p = 0.93).ConclusionsBalloon angioplasty of intermediate IP artery stenosis with mild or moderate PB led to smaller lumen area at follow‐up than before EVT.
Iatrogenic Aortocoronary Dissection During Coronary Intervention: A Case Series
Authors: Albayati Ammar , Collins Nicholas J. , Boyle Andrew J. , Al‐Omary Mohammed S. 
Published: November 2024

ABSTRACTIatrogenic aortocoronary dissection (IAD) during percutaneous coronary intervention (PCI) is an uncommon and potentially life‐threatening complication. Extension of dissection to the ascending aorta, despite early surgical management, carries a high morbidity and mortality risk. Depending on the severity of dissection, the approach to management ranges from monitoring to surgical intervention; more extensive dissections into the ascending aorta, typically more than 40 mm above the coronary ostium, are considered an indication for surgery. We report six cases of IAD, highlighting the critical considerations concerning conservative management. These cases highlight the potential role of individualized management strategies, demonstrating instances where a conservative stance may prove effective in ensuring an optimal patient outcome and the key procedural features essential to optimize outcomes when considering nonsurgical management.
Translating Solid‐Phase Conformational Memory in the Prophecy of Multi‐stimuli Responsive Low Molecular Weight Gels
Authors: Sharma Himanshu , Pathak Debabrat , Tanwar Niharika , Tiwari Pankaj , Sarma Bipul 
Published: November 2024

AbstractPolymorphism and its screening to select the best‐performing form is in high demand. In low molecular weight organogels (LMWG), gelators are designed as they contain flexible groups, functionalities capable of varied H‐bonding, and increased the potential to show polymorphism. We synthesized a bis‐urea based LMWG G1 and isolated three distinct polymorphic phases (Form I, II, and III). G1 polymorphs showed noticeable differences in solubility; precisely, Form I is highly soluble compared to the other two. Gel screening was carried out for all three polymorphs using different stimuli like heat‐cool, sonication, shaking, and grinding. Among the polymorphs, Form I was found to have better gelling ability which was reflected by the solvent scope, thermal stability (gel‐sol transition temperature Tgel), minimum gelator concentration (M.G.C.), stimuli‐responsiveness, morphology, and rheological properties. The differences in their gelation performance among the three polymorphs are associated with their solubility parameter. Stimuli like sonication, shaking, and grinding triggered Form I to form a gel. Form II and III responded to heat‐cool stimuli only due to poor solubility. Therefore, it is noted crucial to add polymorph screening as an integral part of the gel synthesis to avoid problems associated with reproducibility in the gel prophecy of LMWG systems.
Investigation on vapour–liquid equilibrium (VLE) solubility of CO2 in aqueous solutions of amino sugars
Authors: Sarode Urvashi K. , Rawate Hitesh D. , Vaidya Prakash D. 
Published: November 2024

AbstractAmino sugars, which are candidate CO2‐capturing solvents, react reversibly with CO2, thereby setting up vapour–liquid equilibrium (VLE). Knowing equilibrium data is useful for designing gas–liquid contactors for CO2 absorption. In this work, VLE data for two amino sugars, glucosamine (GA) and N‐methyl‐D‐glucamine (NMG), was measured and reported at 303, 308, and 313 K using a high‐pressure VLE setup for the first time. The equilibrium CO2 partial pressure was high (up to 1500 kPa). The molarity of sugar in the aqueous solution was in the 0.5–1.25 M range. It was found that the CO2 loading capacity of NMG was much higher than that of GA. For instance, 1.25 M NMG loaded 1.066 mol/mol at 303 K and 1500 kPa CO2 partial pressure. Using regression, empirical equations were developed to predict VLE data for GA and NMG. To enable comparison, VLE trials were also performed using two amines, monoethanolamine (MEA) and 2‐amino‐2‐methyl‐1‐propanol (AMP), and an amino acid salt potassium glycinate (PG). It was found that CO2 solubility (α, mol/mol) in NMG was comparable to that in MEA and higher than that in PG. Besides, it was also found that CO2 was most soluble in AMP. The effect of promoter addition on the loading capacity at T = 308 K was studied too. The value of CO2 solubility in GA solution (1 M) at = 1450 kPa was α = 0.298 mol CO2/mol amino sugar. It improved to α = 0.46 mol/mol in GA/NMG (1/0.5 M) mixtures. Similarly, the CO2 solubility in NMG solution (0.75 M) at  = 250 kPa was α = 0.76 mol CO2/mol amino sugar. It improved to 0.94 and 0.93 mol/mol in NMG/PZ and NMG/AMP (0.75/0.25 M) mixtures (here, PZ denotes piperazine). In this way, this work provided new and useful VLE data for individual and blended sugar solutions.