bluuebunny/crossref_metadata_2025_split huggingface dataset:
Psychometric evaluation of the Chinese version of the Utrecht Grief Rumination Scale
Authors: Tang Suqin , Eisma Maarten C. , Li Jie , Chow Amy Y.M. 
Published: December 2018

Given the severe mental health consequences that may ensue after bereavement, it is crucial to better understand malleable cognitive factors that are associated with poorer bereavement outcomes. Grief rumination (i.e., repetitive thinking about the causes and consequences of a loss) is a malleable cognitive process that is concurrently and longitudinally associated with postloss mental health problems. To assess grief rumination, the English and Dutch Utrecht Grief Rumination Scale (UGRS) were recently developed. The current study examined the reliability and validity of a Chinese version of the UGRS. Three hundred and ninety‐three Chinese adults (56% women) bereaved on average 16.88 months ago filled out online questionnaires assessing demographic and loss‐related characteristics, grief rumination (UGRS), trait rumination, trait mindfulness, and anxiety, depressive, and prolonged grief symptoms. Confirmatory factor analyses showed that a second‐order five‐factor hierarchical model provided the most optimal factor structure for the Chinese UGRS. UGRS total scale and subscale scores demonstrated acceptable internal consistency. Grief rumination had a moderate positive association with trait rumination and a low negative association with trait mindfulness, providing convergent and discriminant validity evidence. Test‐criterion validity evidence was also provided. UGRS scores could distinguish bereaved groups with different relationships with the deceased. Moreover, grief rumination was associated with symptoms of anxiety, depression, and prolonged grief even after controlling for demographic and loss‐related variables, trait rumination, and trait mindfulness. The Chinese UGRS appears a valid and reliable instrument to assess grief rumination in Chinese bereaved individuals.
Left ventricular reverse remodelling predicts long‐term outcomes in patients with functional mitral regurgitation undergoing MitraClip therapy: results from a multicentre registry
Authors: Adamo Marianna , Godino Cosmo , Giannini Cristina , Scotti Andrea , Liga Riccardo , Curello Salvatore , Fiorina Claudia , Chiari Ermanna , Chizzola Giuliano , Abbenante Alessandro , Visco Emanuele , Branca Luca , Fiorelli Francesca , Agricola Eustachio , Stella Stefano , Lombardi Carlo , Colombo Antonio , Petronio Anna Sonia , Metra Marco , Ettori Federica 
Published: December 2018

AimsTo explore whether left ventricular reverse remodelling (LVRR) is a predictor of outcomes in patients with functional mitral regurgitation (FMR) undergoing MitraClip procedure.Methods and resultsWe analysed 184 consecutive patients with FMR who underwent successful MitraClip procedure. LVRR was defined as a reduction in left ventricular end‐systolic volume ≥ 10% from baseline to 6 months. LVRR was observed in 79 (42.9%) patients. Compared with non‐LVRR, LVRR patients were more likely to be females, less likely to have an ischaemic aetiology of mitral regurgitation or a prior (<6 months) heart failure (HF) hospitalization, and had smaller left ventricular dimensions. New York Heart Association class improved from baseline up to 1‐year follow‐up in both groups. Higher rates of overall survival (87.3% vs. 75.2%, P = 0.039), freedom from HF hospitalization (77.2% vs. 60%, P = 0.020), and freedom from the composite endpoint (cardiovascular mortality or HF hospitalization) (74.7% vs. 55.2%; P = 0.012) were observed in LVRR vs. non‐LVRR patients at 2‐year follow‐up. LVRR was associated with a significant reduction of the adjusted relative risk of mortality, HF hospitalization and composite endpoint [hazard ratio (HR) 0.44; 95% confidence interval (CI) 0.20–0.96, P = 0.040; HR 0.55; 95% CI 0.32–0.97, P = 0.038; and HR 0.54; 95% CI 0.32–0.92, P = 0.023, respectively]. Female gender, absence of diabetes, freedom from prior HF hospitalization, non‐ischaemic aetiology of mitral regurgitation, and left ventricular end‐diastolic diameter < 75 mm were found to be independent predictors of LVRR.ConclusionsLeft ventricular reverse remodelling is associated with better long‐term outcomes in patients with FMR successfully treated with MitraClip. A careful patient selection may be useful as specific baseline features predict favourable left ventricular remodelling. [Correction added on 17 January 2019, after online publication: the preceding sentence has been changed.]
Investigation of a Thin‐film Quasi‐reference Electrode Fabricated by Combined Sputtering‐evaporation Approach
Authors: Wang Nan , Kanhere Elgar , Tao Kai , Hu Liangxing , Wu Jin , Miao Jianmin , Triantafyllou Michael S. 
Published: December 2018

AbstractThis paper presents the development of a thin‐film quasi‐reference electrode (tQRE), which was fabricated by sputtering silver (Ag) on a conducting gold layer. The Ag layer was subsequently covered by silver chloride (AgCl) with the aid of e‐beam evaporation. The functionality of the tQREs as reliable reference electrodes was confirmed by observing the potential response in solutions with various chloride ion concentrations. The influence of solution pH on the potential change of the tQREs was evaluated. In the solution with controlled ionic strength, the tQREs were able to provide stable and consistent potential outputs. Experimental investigation of the electrochemical sensors with integrated tQREs demonstrated potential applicability of the tQREs to be incorporated into miniaturized and disposable lab‐on‐a‐chip sensors for point‐of‐care/in‐situ measurements.
Electrochemical Portable Method for on site Screening of Scopolamine in Beverage and Urine Samples
Authors: da Costa Oliveira Thiago , Santana Mário H. P. , Banks Craig E. , Munoz Rodrigo Alejandro Abarza , Richter Eduardo Mathias 
Published: December 2018

AbstractScopolamine (SCP) is a psychoactive drug often added to beverages for recreational or abuse purposes (loss of memory and non‐consensual practices). In this work, a simple and portable method for fast in field screening of SCP in beverage (beer, coke, energy drink, sugarcane spirit, vodka, and whisky) and urine samples is presented. The proposed method is based on batch injection analysis with square wave voltammetric (BIA‐SWV) detection using boron‐doped diamond (BDD) as the working electrode. A voltammetric profile with accurate information on the presence or absence of SCP is obtained using a small sample volume (∼50 μL) and a simple sample pretreatment step (dilution in supporting electrolyte). Around two hundred analyses are possible using the proposed system (injection of single sample plug – 120 μL) without the need of electrodes handling or supporting electrolyte exchange (friendly to point‐of‐care or on site screenings). The quantification of SCP in beverages is also possible using the proposed portable protocol, with a limit of detection of 0.18 μmol L−1 and recovery values between 87 to 113 %.
Honey and Pollen Phenolic Composition, Antioxidant Capacity, and DNA Protecting Properties
Authors: Issaad Fatima Zohra , Fernandes Isabel P. G. , Enache Teodor Adrian , Mouats Chabane , Oliveira‐Brett Ana Maria 
Published: December 2018

AbstractThe phenolic composition, antioxidant capacity, and the dsDNA oxidative damage protecting properties, of ten honey and two pollen samples, from different countries, Portugal, Algeria, Romania, and Greece, using differential pulse voltammetry, DPPH.spectrophotometric assay, reversed‐phase high performance liquid chromatography with electrochemical detection, and agarose gel electrophoresis, were investigated. The honey samples highest antioxidant capacity was from Multi floral from Greece and the lowest for Mono floral black locust from Romania. The pollen from Romania presented higher antioxidant capacity compared with the pollen from Portugal but both pollen samples have a greater antioxidant capacity compared with the honey samples. In the presence of honey and pollen the DNA oxidative damage, induced by hydroxyl radicals generated through the Fenton reaction, was decreased.
Prevalence and correlates of a positive screen for eating disorders among Syrian refugees
Authors: Aoun Antoine , Joundi Janine , El Gerges Najwa 
Published: December 2018

AbstractThe objective of this cross‐sectional study was to examine the prevalence and correlates of a positive screen for eating disorders (EDs) in a sample of Syrian refugees living in North Lebanon. The study was conducted on a convenience sample of 450 (84.67% women and 15.33% men) refugees, aged between 18 and 45 years. The prevalence of a positive screen for ED was 5.79%. Bivariate analyses revealed that female gender (p = 0.02), presence of medical conditions (p = 0.01), old occurrence of major stressful life event (p < 0.01), and positive primary care post‐traumatic stress disorder screen (p < 0.01) were associated with the positive sick, control, one stone, fat, food tool. Multiple logistic regression analyses showed that subjects screened with post‐traumatic stress disorder had a three times higher risk of having a positive screen for ED (odds ratio = 3.2; 95% confidence interval [1.32, 7.78]). Early detection of ED and related factors may help identify refugees who would benefit from interventions to improve mental health.
The trilogy of China cotton markets: The lead–lag relationship among spot, forward, and futures markets
Authors: Demir Mert , Martell Terrence F. , Wang Jun 
Published: December 2018

AbstractChina is a leading participant in the world cotton market. China’s distinctive regulatory structure and procedures and business environment provide an opportunity to explore some unique market dynamics. This study investigates the interrelationship among the spot, futures, and forward cotton markets in China over a period of a major policy change: A temporary State reserve program for cotton that was established in 2011 and ended in 2014. This government intervention significantly distorted the way farmers, manufacturers, and speculators interacted and was not sustainable. Overall, our results support futures market’s dominant role in the price discovery process.
A new report of the early Palaeozoic hornblendite in South China and its tectonic significance
Authors: Shu Xujie , Gao Tianshan , Zhou Xiaohua , Li Haili 
Published: December 2018

Outcrops of early Palaeozoic mafic rocks are limited in the South China Block (SCB), which become a barrier to unlock the related tectonic evolutionary history. We present a new report of early Palaeozoic Pengxi hornblendite at Xiajiang County, Jiangxi Province, in this paper. The Pengxi hornblendite has a concordant zircon U–Pb age of 433 ± 2 Ma (40 grains) which could represent its formation time. It is characterized by high MgO content (16.8–19.6 wt.%) and Mg# (78–80), compatible elements concentration (Ni = 280–506 ppm, Cr = 1,580–1,780 ppm), and evident depletions of Nb, Ta, and Ti which are similar to the arc‐related magmatism. Combining with the enriched Nd (εNd(t) = −5.3 to −7.8) isotopic feature, we suggest that the hornblendite was derived from partial melting of metasomatized subcontinental lithospheric mantle (SCLM). The lack of other field geological evidences in the study and adjacent areas, such as volcanic rocks, pyroclastic sedimentary rocks, and turbidites, did not support the contemporaneous subduction model. The study area is located near the boundary of the Yangtze and Cathaysia blocks which was a Neoproterozoic subduction belt characterized by ophiolites, volcanic rocks, and turbidites. Mafic rocks formed at different periods (e.g., 800, 500, and 430 Ma) in the SCB have similar enriched Nd isotopic compositions and La/Nb ratios which suggest that the Silurian hornblendite with arc‐like geochemical features may not be the result of contemporaneous subduction but likely inherited from the Neoproterozoic subduction. During Silurian post‐orogenic collapse event, the partial melting of enriched SCLM generated the Pengxi hornblendite. This work can provide new data to the further discussion of the controversies in the tectonic background of the SCB.
An empirical evaluation of multivariate lesion behaviour mapping using support vector regression
Authors: Sperber Christoph , Wiesen Daniel , Karnath Hans‐Otto 
Published: December 2018

AbstractMultivariate lesion behaviour mapping based on machine learning algorithms has recently been suggested to complement the methods of anatomo‐behavioural approaches in cognitive neuroscience. Several studies applied and validated support vector regression‐based lesion symptom mapping (SVR‐LSM) to map anatomo‐behavioural relations. However, this promising method, as well as the multivariate approach per se, still bears many open questions. By using large lesion samples in three simulation experiments, the present study empirically tested the validity of several methodological aspects. We found that (i) correction for multiple comparisons is required in the current implementation of SVR‐LSM, (ii) that sample sizes of at least 100–120 subjects are required to optimally model voxel‐wise lesion location in SVR‐LSM, and (iii) that SVR‐LSM is susceptible to misplacement of statistical topographies along the brain's vasculature to a similar extent as mass‐univariate analyses.
The impact of e‐wallet on informal farm entrepreneurship development in rural Nigeria
Authors: Uduji Joseph Ikechukwu , Okolo‐Obasi Elda Nduka , Asongu Simplice Anutechia 
Published: December 2018

AbstractTransforming agriculture from a largely subsistence enterprise to a profitable commercial venture is both a prerequisite and a driving force for accelerated development and sustainable growth in sub‐Saharan Africa. The objective of this investigation is to assess the impact of the Federal Government of Nigeria (FGN) e‐wallet program on informal farm entrepreneurship development in rural Nigeria. Informal sector farmers are those that are not legally registered at the national level although could be connected to a registered association.The research is motivated by the absence of literature focusing on the problem statement or objective of the study. One thousand one hundred and fifty‐two rural farmers were sampled across the six geopolitical zones of Nigeria. Results from the use of a bivariate probit model indicate that the mobile phone‐based technology via the e‐wallet program is a critical factor that has enhanced farm entrepreneurship in rural Nigeria. However, results also show that the impact of mobile phones (as a channel to accessing and using modern agricultural inputs) is contingent on how mobile networks are able to link farmers who live in rural areas and work mainly in farming. The results suggest that increasing mobile phone services in rural Nigeria enhances farmers' knowledge, information, and adoption of improved farm inputs and by extension, spurs rural informal sector economic activities in sub‐Saharan Africa. Implications for practice, policy, and research are discussed.
A facility mandate for pharmacist assessment improves venous thromboembolism outcomes
Authors: Cole Jennifer L. , Stark Jennifer E. 
Published: December 2018

BackgroundNarrowing the implementation gap for prophylaxis of venous thromboembolism (VTE) continues to be a challenge for many health care facilities. A primary Veterans Affairs (VA) facility implemented a new mandate for pharmacy assessment of VTE risk factors in acute care patients with required documentation in the permanent medical record using a novel electronic note and template. The purpose of this study was to evaluate the effect of this innovative intervention on VTE outcomes.MethodsBeginning in January 2014, a clinical pharmacist reviewed hospitalized patient profiles within 48 hours of admission at the study facility. Risk factors for VTE were identified and the presence or absence of appropriate pharmacologic prophylaxis was documented in an electronic note. If pharmacologic prophylaxis was indicated but not given, the provider was added to the note as a required additional signer. This was a retrospective review of aggregated data from October 2008 to June 2018. The primary outcome was incidence of VTE events before and after the 2014 intervention. Secondary outcomes included 30‐day readmissions for VTE and percentage of high‐risk patients with VTE prophylaxis present.ResultsThere were a total of 36 474 discharges encompassed in the study period; 23 202 before and 13 272 after the 2014 required pharmacist assessment. The incidence of VTE decreased from 0.20% to 0.11% (odds ratio [OR] 1.90; confidence interval [CI] 1.04‐3.46, P = 0.039). The incidence of 30‐day readmissions for VTE also decreased from 0.16% to 0.04% (OR 4.12; CI 1.67‐10.19, P = 0.001). High‐risk diagnoses had a similar rate of pharmacologic prophylaxis (82% vs 86%; P = 0.31).ConclusionA facility mandate for pharmacy assessment of VTE risk factors with the development of a novel electronic note and required documentation in the medical record decreased preventable VTE events.
An antibiofilm coating of 5‐aryl‐2‐aminoimidazole covalently attached to a titanium surface
Authors: Peeters Elien , Hooyberghs Geert , Robijns Stijn , De Weerdt Ami , Kucharíková Soňa , Tournu Hélène , Braem Annabel , Čeh Katerina , Majdič Gregor , Španič Tanja , Pogorevc Estera , Claes Birgit , Dovgan Barbara , Girandon Lenart , Impellizzeri Frédéric , Erdtmann Martin , Krona Annika , Vleugels Jef , Fröhlich Mirjam , Garcia‐Forgas Jordi , De Brucker Katrijn , Cammue Bruno P.A. , Thevissen Karin , Van Dijck Patrick , Vanderleyden Jozef , Van der Eycken Erik , Steenackers Hans P. 
Published: December 2018

AbstractBiofilms, especially those formed by Staphylococcus aureus, play a key role in the development of orthopedic implant infections. Eradication of these infections is challenging due to the elevated tolerance of biofilm cells against antimicrobial agents. In this study, we developed an antibiofilm coating consisting of 5‐(4‐bromophenyl)‐N‐cyclopentyl‐1‐octyl‐1H‐imidazol‐2‐amine, designated as LC0024, covalently bound to a titanium implant surface (LC0024‐Ti). We showed in vitro that the LC0024‐Ti surface reduces biofilm formation of S. aureus in a specific manner without reducing the planktonic cells above the biofilm, as evaluated by plate counting and fluorescence microscopy. The advantage of compounds that only inhibit biofilm formation without affecting the viability of the planktonic cells, is that reduced development of bacterial resistance is expected. To determine the antibiofilm activity of LC0024‐Ti surfaces in vivo, a biomaterial‐associated murine infection model was used. The results indicated a significant reduction in S. aureus biofilm formation (up to 96%) on the LC0024‐Ti substrates compared to pristine titanium controls. Additionally, we found that the LC0024‐Ti substrates did not affect the attachment and proliferation of human cells involved in osseointegration and bone repair. In summary, our results emphasize the clinical potential of covalent coatings of LC0024 on titanium implant surfaces to reduce the risk of orthopedic implant infections. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 107B: 1908–1919, 2019.
LncRNA NEAT1 promotes extracellular matrix accumulation and epithelial‐to‐mesenchymal transition by targeting miR‐27b‐3p and ZEB1 in diabetic nephropathy
Authors: Wang Xiaowei , Xu Yong , Zhu Ying‐Chun , Wang Ya‐Kun , Li Ji , Li Xiao‐Ying , Ji Tingting , Bai Shou‐Jun 
Published: December 2018

AbstractDiabetic nephropathy (DN) is a kind of microvascular complications of diabetes. Long noncoding RNAs (lnRNAs) can participate in the development of various diseases, including DN. However, the function of lncRNA NEAT1 is unclear. In our present study, we reported that NEAT1 was significantly increased in streptozotocin‐induced DN rat models and high‐glucose‐induced mice mesangial cells. We observed that knockdown of NEAT1 greatly inhibited renal injury of DN rats. Meanwhile, downregulation of NEAT1‐modulated extracellular matrix (ECM) proteins (ASK1, fibronectin, and TGF‐β1) expression and epithelial–mesenchymal transition (EMT) proteins (E‐cadherin and N‐cadherin) in vitro. Previously, miR‐27b‐3p has been reported to be involved in diabetes. Here, miR‐27b‐3p was decreased in DN rats and high‐glucose‐induced mice mesangial cells. The direct correlation between NEAT1 and miR‐27b‐3p was validated using the dual‐luciferase reporter assay and RNA immunoprecipitation experiments. In addition, zinc finger E‐box binding homeobox 1 (ZEB1), which has been identified in the process of EMT clearly contributes to EMT progression. ZEB1 was predicted as a target of miR‐27b‐3p and overexpression of miR‐27b‐3p dramatically repressed ZEB1 expression. Therefore, our data implied the potential role of NEAT1 in the fibrogenesis and EMT in DN via targeting miR‐27b‐3p and ZEB1.
MSI‐L/EMAST is a predictive biomarker for metastasis in colorectal cancer patients
Authors: Torshizi Esfahani Amir , Seyedna Seyed Yoosef , Nazemalhosseini Mojarad Ehsan , Majd Ahmad , Asadzadeh Aghdaei Hamid 
Published: December 2018

AbstractBackgroundMicrosatellite instability (MSI) is a prognostic marker in colorectal cancer (CRC). The biological significance of MSI‐low (MSI‐L) phenotype and its differences with microsatellite stable (MSS) phenotype remains unclear. The aim of this study is indicating the role of mononucleotide repeat in identifying MSI‐L and revealing the association of MSI‐L with elevated microsatellite alterations at selected tetranucleotide repeats (EMAST) and oncologic outcome in CRC patients.MethodsMSI and EMAST status were analyzed using three quasimonomorphic panel (BAT‐25, BAT‐26, and NR‐27) and five tetranucleotide repeats (D20S82, D20S85, D9S242, D8S321, and MYCL1), respectively, by capillary electrophoresis method without the need to fluorescent primers. The associations of MSI status with clinicopathological features, EMAST status, metastasis, and overall survival (OS) were investigated.ResultsAmong 159 CRC patient 22.0% were MSI‐H, 40.3% were MSS, 37.7% were MSI‐L, and 41.5% showed EMAST + phenotype. MSI‐L were associated with advanced stages, EMAST+ tumors and worse OS (
p ≤ 0.001). Metastasis was relatively common in MSI‐L/EMAST
+ CRCs and BAT‐25 were the most unstable marker in these tumors.ConclusionsMSI‐L tumors have different clinicopathological features from MSS and MSI‐H tumors. The MSI‐L phenotype is a worse prognostic biomarker in CRC and when accompanied by EMAST could be a predictor for metastasis.