bluuebunny/crossref_metadata_2025_split huggingface dataset:
RESPON TULANG FEMUR TIKUS OSTEOPOROSIS YANG MENGKONSUMSI CALCITRIOL
Authors: Hartiningsih Hartiningsih , Anggraeni Devita 
Published: October 2018

Calcitriol supplementation in ovariectomized rats decreased bone resorption and increased bone formation, however, it depend on dose. The objective of the research was to study the response of femur bone in osteoporosis rats consuming calcitriol. Thirty female Wistar rats at 8 weeks of age were randomly divided into six groups (sham operated rats as normal control rats/group N and NK, ovariectomized control rats/group Ov and OvK, ovariectomized rats/group OvDand OvE) of five each. All rats were fed standard diet for 8 weeks. At 16 weeks of age, group N and Ov were euthanized, the right femur were taken for histopathological examination. Group NK and OvK were fed a standard diet, group OvD was fed a standard diet +40ng calcitriol; and group OvE was fed a standard diet+25µg ethynil ethyl estradiol. Treatments were done for six weeks. At the end of study, blood samples were taken from plexus orbitalis medialis for estrogen analysis. All rats were euthanized using ketamine10% and xylazine 2%. Right femur was taken for histopathological examination using hematoxylin and eosin stain, and immunohistochemistry using monoclonal antibody anti TRAP5b which was detected with streptavidin-biotin. The results showed that estradiol level of the rats in group OvD was not significantly different compared with the rats in OvK group, however, it was significanly lower compared to the rats in group OvE. Histopathologic figure of right distal femur metaphysis in group OvD was shown lesser adipocyte in the bone marrow and more trabecular bone speculum compared to group OvK, however, there was more adipocyte in the bone marrow and lesser trabecular bone speculum compared to group OvE. Immunohistochemistry of distal femur metaphysis in group OvD and OvE were revealed tartrate resistant alkaline phosphatase 5b (TRAP5b) expression in trabecular bone, which was located in bone marrow space and trabecular speculum surface as well. Based on the results, it can be concluded that calcitriol 40ng/day supplementation in osteoporosis rats for 6 weeks decreased bone resorption and increased bone formation distal femur metaphysis.
Perkembangan Resistensi Escherichia coli terhadap Oksitetrasiklin
Authors: Indarjulianto Soedarmanto , Nururrozi Alfarisa , Yanuartono Yanuartono , Rusmihayati Rusmihayati , Widyarini Sitarina , Sari Puspa Wikan , Pramono Vembriarto Jati 
Published: October 2018

Antimicrobial resistance is amongst the primary concern in the field of veterinary medicine worldwide. The research was conducted to evaluate the resistance of Escherichia coli due to inappropriate antibiotic treatment. Escherichia coli in this research was cultured in vitro using 5-ml Tryptone Soya Broth (TSB), which was mixed with an antibiotic, then was incubated at 37 0C for four days (stage I). Subsequently, a part of the culture was transferred into another 5-ml TSB and incubated at 37 0C for four days (stage II). This procedure was undertaken continuously for stage III, IV, V,and VI (until day 24). Antibiotics in this research was oxytetracycline with three various doses, which are lower dose (1 mg/ml), normal dose (2 mg/ml), and higher dose (8 mg/ml). The development of the antrimocobial resistance was evaluated every four days, using disk diffusion method and the data were analysed descriptively. The results showed that the normal and higher doses of oxytetracycline has the same rate (day 16) in causing E. coli resistant to oxytetracycline. Therefore, the treatment of oxytetracycline with a normal and higher doses continuously could accelerate the emergence of antimicrobial resistance in Escherichia coli.
KEBIJAKAN TRANSPLANTASI GINJAL DI INDONESIA
Authors: Dewi Makassari 
Published: October 2018

Within the last few years there have been an increasing number of patients with end stage renal desease (ESRD). But the increase is not offset by the amount of the maximum service ESRD therapy. Compared with countries in the world, a renal transplant in Indonesia is still far behind. One of the hurdles is still weak due to regulatory support renal transplant in Indonesia. This article aims to look at the policy issues become an obstacle in the implementation of a renal transplant in Indonesia. This paper uses methods of regulatory reviews and articles related to a renal transplant. The analysis shows that the legal basis for a renal transplant in the form of existing legislation. However, the absence of specific regulations for a renal transplant and the decease donor in the form of technical instructions and guidelines for implementation rules became one of the obstacles in the development of renal transplantation in Indonesia. Renal transplants are covered by government funding, but still found gaps allocation of the amount of financing required a renal transplant so that implementation of clinical pathways on budgetary renal transplant is needed.
ABSTRAK
Dalam kurun waktu beberapa tahun belakangan ini telah terjadi peningkatan jumlah penderita penyakit ginjal kronis (PGK) stadium akhir di Indonesia. Namun meningkatnya jumlah tersebut belum diimbangi dengan pelayanan yang maksimal terhadap terapi PGK stadium akhir. Dibandingkan dengan negara di dunia, transplantasi ginjal di Indonesia masih jauh tertinggal. Salah satu hambatannya adalah disebabkan masih lemahnya dukungan regulasi transplantasi ginjal di Indonesia. Tulisan ini bertujuan untuk melihat permasalahan kebijakan yang menjadi kendala dalam pelaksanaan transplantasi ginjal di Indonesia. Tulisan ini menggunakan metode review peraturan dan artikel terkait transplantasi ginjal. Hasil analisa menunjukkan bahwa payung hukum terhadap transplantasi ginjal dalam bentuk perundang-undangan sudah ada. Namun, belum adanya peraturan spesifik terhadap transplantasi ginjal dan donor jenazah dalam bentuk petunjuk teknis dan pedoman peraturan pelaksanaannya menjadi salah satu kendala dalam pengembangan transplantasi ginjal di Indonesia. Transplantasi ginjal sudah ditanggung pembiayaannya oleh pemerintah, namun masih ditemukan kesenjangan alokasi besaran pembiayaan transplantasi ginjal sehingga diperlukan penerapan clinical pathways transplantasi ginjal pada penyusunan anggaran transplantasi ginjal.
PEMODELAN ANGKA HARAPAN HIDUP (AHH) LAKI-LAKI DAN PEREMPUAN DI INDONESIA TAHUN 2016
Authors: Maryani Herti , Kristiana Lusi 
Published: October 2018

Life Expectancy is a tool for evaluating government performance in improving the welfare of the population in general, and improving health status in particular. Research on life expectancy is necessary, as life expectancy is an important indicator of health and economic development. The research aims to make the modeling of life expectancy of men and women in Indonesia based on health variables that exist in susenas 2016. This research is a research of secondary data with multiple linear regression analysis. There were 17 predictor variables analyzed for female AHH and 13 predictor variables for male AHH. Most of the variables are health variables. there are only 2 variables of all variables were signifi cant to female AHH. there are only 4 variables were signifi cant to male AHH The regression model shows that AHH has a higher constant than the male AHH. The results show that the variables that give signifi cant effect to the female AHH were the percentage of people who ever been hospitalized, Toddler age 0–2 year was still breastfed and the household using the toilet facility. For male AHH the signifi cant variables are Toddler age 0–2 year was still breastfed, household using the toilet facility, and residents using health insurance for inpatient and outpatient.
Abstrak
Angka Harapan Hidup (AHH) merupakan alat untuk mengevaluasi kinerja pemerintah dalam meningkatkankesejahteraan penduduk pada umumnya, dan meningkatkan derajat kesehatan pada khususnya. Penelitian mengenai AHH sangat diperlukan, mengingat Angka Harapan Hidup merupakan indikator penting pembangunan kesehatan dan ekonomi. Penelitian bertujuan untuk membuat pemodelan AHH laki-laki dan perempuan di Indonesia berdasarkan variabel yang ada di susenas 2016. Penelitian ini merupakan penelitian data sekunder dengan analisis regresi linier berganda. Terdapat 17 variabel prediktor yang dianalisis untuk AHH perempuan dan 13 variabel prediktor untuk AHH laki-laki. Sebagian besar variabel merupakan variabel kesehatan. Dari variabel tersebut hanya 3 variabel prediktor yang signifi kan terhadap AHH perempuan dan 4 variabel yang signifi kan terhadap AHH laki-laki. Model regresi menunjukkan AHH perempuan mempunyai konstanta yang lebih besar daripada AHH laki-laki. Hasil penelitian menunjukkan bahwa variabel yang memberi pengaruh signifi kan terhadap AHH perempuan adalah persentase penduduk yang pernah rawat inap, Baduta masih ASI dan rumah tangga yang menggunakan fasilitas buang air besar (BAB). Untuk AHH laki-laki variabel yang signifi kans adalah Baduta masih ASI, rumah tangga yang menggunakan fasilitas buang air besar (BAB),serta penduduk yang menggunakan jaminan kesehatan untuk rawat inap dan rawat jalan.
A Type 1 Diabetes Genetic Risk Score Can Identify Patients With GAD65 Autoantibody–Positive Type 2 Diabetes Who Rapidly Progress to Insulin Therapy
Authors: Grubb Anita L. , McDonald Timothy J. , Rutters Femke , Donnelly Louise A. , Hattersley Andrew T. , Oram Richard A. , Palmer Colin N.A. , van der Heijden Amber A. , Carr Fiona , Elders Petra J.M. , Weedon Mike N. , Slieker Roderick C. , ’t Hart Leen M. , Pearson Ewan R. , Shields Beverley M. , Jones Angus G. 
Published: October 2018

OBJECTIVEProgression to insulin therapy in clinically diagnosed type 2 diabetes is highly variable. GAD65 autoantibodies (GADA) are associated with faster progression, but their predictive value is limited. We aimed to determine if a type 1 diabetes genetic risk score (T1D GRS) could predict rapid progression to insulin treatment over and above GADA testing.RESEARCH DESIGN AND METHODSWe examined the relationship between T1D GRS, GADA (negative or positive), and rapid insulin requirement (within 5 years) using Kaplan-Meier survival analysis and Cox regression in 8,608 participants with clinical type 2 diabetes (onset &gt;35 years and treated without insulin for ≥6 months). T1D GRS was both analyzed continuously (as standardized scores) and categorized based on previously reported centiles of a population with type 1 diabetes (&lt;5th [low], 5th–50th [medium], and &gt;50th [high]).RESULTSIn GADA-positive participants (3.3%), those with higher T1D GRS progressed to insulin more quickly: probability of insulin requirement at 5 years (95% CI): 47.9% (35.0%, 62.78%) (high T1D GRS) vs. 27.6% (20.5%, 36.5%) (medium T1D GRS) vs. 17.6% (11.2%, 27.2%) (low T1D GRS); P = 0.001. In contrast, T1D GRS did not predict rapid insulin requirement in GADA-negative participants (P = 0.4). In Cox regression analysis with adjustment for age of diagnosis, BMI, and cohort, T1D GRS was independently associated with time to insulin only in the presence of GADA: hazard ratio per SD increase was 1.48 (1.15, 1.90); P = 0.002.CONCLUSIONSA T1D GRS alters the clinical implications of a positive GADA test in patients with clinical type 2 diabetes and is independent of and additive to clinical features.
Design of Pyramidal Horn Antenna for 2.45GHz in FEKO for Application in Experimental FSO/RF Hybrid System
Authors: Márton Michal , Ovseník Ľuboš , Turán Ján , Špes Michal 
Published: October 2018

Abstract
Communication technologies are growing for day to day because demand on data sharing is unstoppable. Users require availability of approach to network at all time. Implementation of smart technologies allows communication of all type of devices. Capacity of data flow have to grow. Video formats HD or 4K require transmit on high data speed. Based on the demands many types of different communication systems which are suitable for these speeds were designed. One of these systems is FSO (Free Space Optics). FSO system is based on transmission of optical beams which carry the information. This system allow high data speed comparable with standard optical fiber in range to 10km. One of drawbacks of this system is LOS (Light of Sight) between communication points. The other drawback is sensitivity to weather changes. Optical beams interfere with water particles and cause attenuation on transmission path. The solution is in implementation using hybrid FSO/RF system which combines optical communication system with RF (Radio Frequency) backup link. We realized FSO communication link on Technical University of Košice. Our research is focused on design of appropriate type of antenna for our RF backup link. Our results in this area were published.
New Solar Water Heating System: Safety, Design and Implementation Issues
Authors: Santos Victor D. N. , Cerveira Manuel , Moita Fernando 
Published: October 2018

Abstract
This paper presents a new electronic controller, devoted to solar water heating systems, that implements safety functions to prevent L. pneumophila bacteria outbreaks. The controller uses data retrieved from strategically located probes in order to implement the proposed safety actions. The electronic solution was integrated and validated on a solar system prototype bench that uses real equipment such as collectors, a water storage tank and expansion vessels. Moreover, two particular solar water heating installations were designed devoted to a house family and a nursing home both located on the Mealhada area. The methodology and reported technical solutions in this research could be a practical guide to promote mass market usage of the solar water heating systems in Portugal.
Simulation of Downlink of 10G-PON FTTH in the city of Košice
Authors: Huszaník Tomáš , Turán Ján , Ovseník Ľuboš 
Published: October 2018

AbstractOptical fiber has the great advantages of capacity and reliability. That is why network providers started to deploy FTTx (Fiber-To-The-x) optical access using various PON (Passive Optical Network) architectures. The leading technology right now is Gigabit PON (GPON). However, with increasing amount of multimedia we need to further develop existing technologies to go on with these high demands. Fiber-To-The-Home (FTTH) using 10G-PON technology for broadband access application is effective solution for high speed networks with high capacity. In this paper, we look at the passive optical network in the city of Košice and based on the real network we created simulation model of downlink of 10G-PON based FTTH with triple-play service.
Personal data acquisition IOT gateway
Authors: Vamos Daniel , Oniga Stefan , Alexan Anca 
Published: October 2018

Abstract
Personal activity tracker are nowadays part of our lives. They silently monitor our movements and can provide valuable information and even important alerts. But usually the user’s data is stored only on the activity tracker device and the processing done is limited by this modest processing power device. Thus it is very important that the user’s data can be stored and processed in the cloud, making the activity tracker an IOT node. This paper proposes a simple IOT gateway solution for a custom user monitoring device.
Stability study of the neural network at particle physics detectors
Authors: Majoros Tamás , Ujvári Balázs 
Published: October 2018

Abstract
Neural networks are used as triggers at highenergy physics detectors. These triggers can separate the event that must be saved for later analysis from the other events or noises. Using the raw data of the detector, the signal and the background can be separated offline. After separation, sets of signals and backgrounds can be used to train the neural network. A gas-filled detector (multiwire proportional chamber) was used to study the trigger at different noise levels to find the most stable neural network that tolerates the random hits. The ratio of the recognized and the unrecognized signal and background events is used for the measurement. Its stability is part of the systematical uncertainty.
Flawed Ideologies, Propaganda and the Social Situatedness of Knowledge
Authors: Amoretti Maria Cristina 
Published: October 2018

Abstract
In this paper I focus on the connection between some of Stanley’s claims about propaganda and flawed ideologies, and the idea of the social situatedness or perspective-relativity of knowledge. More precisely, I will try to show how Stanley’s reflections on the nature of propaganda and its relationship with flawed ideologies push us towards the empiricists’ characterisation of the social situatedness of knowledge. Not only do these reflections reveal some important weaknesses of standpoint theories (that is, the claim of epistemic asymmetry between advantaged and negatively advantaged groups, and the necessity of actively achieving a standpoint), but they also support the request for the pluralism, rational critique, cooperation, fair discussion and epistemic integration fostered by social empiricism. This means that the broad idea of the social situatedness of knowledge should be defended and further developed along the lines sketched by social empiricism.
Identifying Metrics That Matter: What Are the Real Key Performance Indicators (KPIs) That Drive Consumer Behavior?
Authors: Lautman Martin R. , Pauwels Koen 
Published: October 2018

Abstract
Vector auto regression (VAR) is a form of econometric modeling that is receiving increased attention in marketing research applications. It is used to observe whether potentially relevant indicators have a real impact on sales or success factors. Compared with correlation, regression and conjoint techniques, VAR models are superior because they are able to show the impact of changes over time on the basis of real business data. The research shows how VAR models are applied in different marketing settings. VAR models can filter relevant metrics from a whole set of potentially relevant performance indicators and quantify the sales impact of each variable. They further observe lead and lag effects that cannot be tracked when measurement is conducted at a single point in time. Modeling can be performed on competitive brands as well. VAR models also make it possible to test whether the same success factors that drive a category also drive the sales of each of the brands in that category.
Harnessing the medicinal properties of Cussonia barteri Seem. (Araliaceae) in drug development. A review
Authors: Igbe Ighodaro , Edosuyi Osaze , Okhuarobo Agbonlahor 
Published: October 2018

Summary

Cussonia barteri Seem (Araliaceae) is a deciduous tree growing in savannah of Africa. Ethnomedicinally, it is used in Africa as an analgesic, anti-malarial, anti-inflammatory, anti-anaemic, anti-diarhoea, anti-poison, ani-pyschotic and anti-epileptic agent. This review provides a brief summary on the phytochemical screenings, ethnomedicinal and pharmacological applications of various parts of C. barteri. Leaves, stem bark and seed of C. barteri have been shown to be rich in saponins, flavonoids, phenols, sugars and alkaloids. Some of these constituents have been isolated and elucidated from C. barteri. Several compounds isolated from plant include triterpenes, saponins, polyenyne and quinic esters. Phytochemical constituents are also partly responsible for biological activities of C. barteri. Extracts and components isolated from the plant have demonstrated neuropharmacological, anti-larvicidal, anti-microbial, anti-inflammatory and antioxidant activities. Overall, the insights provided by this review reinforce the potential of C. barteri for drug development and create the need for further scientific probe of constituents of the plant with the aim of developing novel drug candidates.
A Rare Cause of Chronic Hepatitis: Celiac Disease
Authors: Sîrbu Oana , Șorodoc Victoriţa , Stoica Alexandra , Ceasovchih Alexandr , Constantin Mihai , Huiban Laura , Dumitrescu Gabriela , Vâţă Luminiţa , Șorodoc Laurenţiu 
Published: October 2018

Abstract

Introduction. Celiac disease is a chronic bowel disease with a prevalence of 1% in the general population. This condition, immune-mediated, may exhibit multiple extra-intestinal changes, including the liver.

Case presentation. We present the case of a 43-year-old patient presenting in our clinic for fatigue, associated with cytolytic and cholestatic hepatic syndrome with an onset of 10 years. During this time, the patient performed multiple investigations with the exclusion of viral, autoimmune etiology, primitive biliary cirrhosis and Wilson's disease. An abdominal ultrasound recorded an elongated, with an infundibular septum gallbladder. Abdominal computer tomography did not detect any changes. The final diagnosis is chronic alithiasic cholecystitis receiving hepatoprotective treatment with symptom relief and improved hepatic disorders. Over the past 2 years, the patient was diagnosed with osteoporosis (T score = -2.7 followed by treatment with Calcium and Vitamin D and improvement in T score to -2.1), and an iron deficiency anemia corrected with oral iron treatment. Upon resuming the anamnesis, we notice the presence of an intermittent bloating associated with diarrhea. Positive anti-transglutaminase antibodies required upper endoscopy with biopsy witch confirmed celiac disease.

Conclusion. Despite the rather low prevalence of celiac disease in the etiology of hepatocytolysis, it is important to investigate its presence in the context of hepatic changes with uncertain etiology. This case motivates us to be rigorous in looking for secondary causes of hepatic impairment even in patients with apparently benign changes.
La indemnización de perjuicios en caso de resolución frente a la existencia de pluralidad de deudores
Authors: Contardo González Juan Ignacio 
Published: October 2018

El artículo indaga la forma de distribución de la indemnización de perjuicios en caso de resolución por incumplimiento frente a la pluralidad de deudores. Se postula que debe distinguirse entre codeudores mancomunados, solidarios e indivisibles.