bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identification of incident pancreatic cancer in Ontario administrative health data: A validation study
Authors: Wu Jennifer W. , Azoulay Laurent , Huang Anjie , Paterson Michael , Wu Fangyun , Secrest Matthew H. , Filion Kristian B. 
Published: October 2018

AbstractPurposeTo validate three approaches for identifying incident cases of pancreatic cancer in Ontario administrative claims data.MethodsWe created a cohort using Ontario (Canada) administrative health data from 2002 to 2012 and identified cases of pancreatic cancer with three approaches, using the Ontario Cancer Registry (OCR) as the reference standard. In the any diagnosis approach, cases were defined by primary or secondary diagnostic codes for pancreatic cancer in outpatient or inpatient records. In the any inpatient diagnosis approach, cases were defined using only diagnoses in hospital discharge abstracts. In the algorithm approach, cases were identified by an algorithm that combined the first two approaches. Comparing each approach to the OCR, we calculated the expected value and 95% confidence interval (CI) of the sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV). We also compared the event dates using each approach with those recorded in the OCR.ResultsAmong a total of 12 060 837 patients in Ontario administrative health data sources, 13 999 incident pancreatic cancer cases were identified in the OCR. Sensitivity ranged from 72.5% (algorithm) to 97.5% (any diagnosis), and PPV ranged from 38.4% (any diagnosis) to 78.9% (any inpatient diagnosis). Specificity and NPV were ~100% for all approaches. The median absolute difference in cancer event date ranged 0 to 15 days. The any inpatient diagnosis method had the highest PPV (78.9%; 95% CI: 78.2‐79.5%) and moderate sensitivity (86.6%; 95% CI: 86.0‐87.2%).ConclusionInpatient diagnoses of pancreatic cancer in Ontario administrative heath data are suitable for pancreatic cancer case identification.
Micro‐Scale Medical Devices Were Big News at MD&M East
Authors: Giordano Geoff 
Published: October 2018

One big theme at MD&M East this year: SmallThe Medical Device and Manufacturing Show, co‐located with Plastec East and four other shows at the Javits Center in New York City between June 12 and 14, offered a slew of plastics‐related innovations amid the 3D printers, laser markers, metrology equipment, and collaborative robots (cobots)
Insights into the molecular mechanism behind solubilization of amyloidogenic polyglutamine‐containing peptides
Authors: Burra Gunasekhar , Thakur Ashwani Kumar 
Published: October 2018

AbstractSynthetic peptides are widely used to understand the protein misfolding and aggregation observed in a diverse group of diseases called systemic amyloidosis and neurodegenerative disorders. The preparation of monomeric solutions of the aggregation‐prone peptides is necessary for achieving a mechanistic understanding efficiently, without compromising any critical step. This study describes novel approaches and mechanisms behind the conversion of otherwise insoluble/sparingly soluble peptides to soluble monomers by trifluoroacetic acid and hexafluoroisopropanol. Although the pretreatment with these solvents results in more or less similar monomers, the mechanism followed to achieve this differs with the solvent. Data show that these solvents aid in the solubility by disrupting the extensive intramolecular and/or intermolecular H‐bond network present in the insoluble peptides.
Micropatterning of poly(p‐phenylene vinylene) by femtosecond laser induced forward transfer
Authors: Almeida Juliana MP , Avila Oriana I , Andrade Marcelo B , Stefanelo Josiani C , Otuka Adriano JG , Paula Kelly T , Balogh Debora T , Mendonça Cleber R 
Published: October 2018

AbstractConjugated polymers are important materials for optical applications, among which poly(p‐phenylene vinylene) (PPV) has a major role due to its applicability in sensors, organic light‐emitting diodes and large area displays. Despite advances on the synthesis of PPV‐based polymers and the improvements of their properties, its printing process, in particular involving the solid phase, remains unsuitable for the development of electro‐optical microcircuits. This paper demonstrates the printing of PPV from the solid phase in 2D micropatterns. Such an achievement was performed using laser induced forward transfer with femtosecond pulses, which allows area‐selective deposition within reduced scales as thin as ca 100 nm and 5 µm wide. Raman, fluorescence and electrochemical impedance spectroscopies confirm that the printed PPV micropatterns have the same structure, emission spectrum and conductivity as the target material, revealing the conservation of their original properties even after laser irradiation. The printing process was carried out using PPV films, overcoming the insolubility issue of this material. The optical and electrical characterization of the transferred PPV demonstrates the potential of this method for the patterning of electro‐optical microdevices, since luminescence and electrical conductivity were preserved. © 2018 Society of Chemical Industry
Verifying the ecological model of peer aggression on Croatian students
Authors: Velki Tena 
Published: October 2018

AbstractUsing the ecological approach, the goal of this study was to determine the predictors of physical and verbal peer aggressive behavior. The participants were 880 school students from the fifth to eighth grade (48% boys and 52% girls) and the same number of parents (19% fathers and 61% mothers) as well as 107 teachers. The main analysis was performed using multivariate–multilevel modeling. The following significant predictors of physical peer aggression were obtained: Boys, a greater degree of impulsivity, more parental punishment, poorer school success, more time spent with the media, and the perception of great neighborhood dangerousness. For verbal peer aggression, the significant predictors were: A greater degree of impulsivity, lower level of affective empathy, more parental punishment, lack of parental supervision, lesser peer acceptance, large differences in family income, more time spent with the media, and the perception of great neighborhood dangerousness. A moderating effect of neighborhood dangerousness and parental supervision was found. The results were interpreted within Bronfenbrenner's ecological model.
Identifying dyslexia with confirmatory latent profile analysis
Authors: Niileksela Christopher R. , Templin Jonathan 
Published: October 2018

AbstractConfirmatory latent profile analysis (CLPA) was used with the normative sample from the Kaufman Test of Educational Achievement, 3rd ed. (KTEA‐3) to determine whether it was possible to identify a latent class of individuals whose scores were consistent with the academic strengths and weaknesses related to dyslexia. The CLPA identified a class of individuals consistent with dyslexia across four‐grade level groups (first–second, third–fifth, sixth–eighth, and ninth–twelfth). The results of the CLPA were applied to the KTEA‐3 clinical samples of those with known clinical diagnoses. Individuals with Specific Learning Disorder in Reading and/or Written Expression had a higher probability of being in the dyslexia latent class. The use of CLPA as a tool for learning disability diagnosis appears plausible, though much more research is needed. The strengths, limitations, and future directions for the use of CLPA in diagnosis are discussed.
Improving oral reading fluency in middle‐school students: A comparison of repeated reading and listening passage preview
Authors: Powell Margaret B. , Gadke Daniel L. 
Published: October 2018

AbstractOral reading fluency has been established in previous literature as a key component in becoming an effective reader. Repeated reading (RR) and listening passage preview (LPP) are both oral reading fluency interventions well‐supported in the research literature, however, most of this study explores their use with elementary‐aged children, with only a handful of studies over the last 20 years evaluating their use in middle‐school children. The overall goal of the current study was to explore the effectiveness of both of these interventions independent and relative to one another. An alternating treatment design (A/ABC), including the use of baseline, was implemented to compare RR, LPP, and a control. Three middle school‐aged struggling readers were randomly exposed to the conditions over time, with oral reading fluency acting as the primary dependent variable. Data were analyzed using visual analysis and effect size calculated using nonoverlap of all pairs (NAP). The results indicated primarily large effects for RR, with LPP effects ranging from small to large across participants. Limitations, implications, and future directions are also discussed.
Cell Wall Proteome Investigation of Bread Wheat (Triticum Aestivum) Developing Grain in Endosperm and Outer Layers
Authors: Cherkaoui Mehdi , Geairon Audrey , Lollier Virginie , Clemente Hélène San , Larré Colette , Rogniaux Hélène , Jamet Elisabeth , Guillon Fabienne , Francin‐Allami Mathilde 
Published: October 2018

AbstractThe remodeling of cell wall polysaccharides is controlled by cell wall proteins (CWPs) during the development of wheat grain. This work describes for the first time the cell wall proteomes of the endosperm and outer layers of the wheat developing grain, which have distinct physiological functions and technological uses. Altogether 636 nonredundant predicted CWPs are identified with 337 proteins in the endosperm and 594 proteins in the outer layers, among which 295 proteins are present in both tissues, suggesting both common and tissue specific remodeling activities. These proteins are distributed into eight functional classes. Approximatively a quarter of them were predicted to act on cell wall polysaccharides, with many glycosylhydrolases and also expansin, lyases, and carbohydrate esterases. Therefore, these results provide crucial data to go further in the understanding of relationship between tissue‐specific morphogenesis and cell wall remodeling in cereals. Data are available via ProteomeXchange with identifier PXD010367.
Polyimide incorporated cyanate ester/epoxy copolymers for high‐temperature molding compounds
Authors: Wu Fan , Song Bo , Hah Jinho , Tuan Chia‐Chi , Moon Kyoung‐Sik , Wong Ching‐Ping 
Published: October 2018

ABSTRACTThe rapid development of high‐power devices has driven the requirement for high‐temperature stable epoxy molding compounds. In this work, a designed polymer blend system consisting of cyanate ester/epoxy copolymers modified by polyimide (CE/EP‐PI) has been studied. Polyimide used in this study has shown excellent dispersity in the cyanate ester and epoxy copolymer network (CE/EP), exhibiting homogeneous phase with a denser polymer network structure. With this polymer blend structure, CE/EP‐PI system was proved to have a glass transition temperature as high as ~270 °C, increased modulus, and largely enhanced fracture toughness up to 2.06 MPa m1/2. CE/EP‐PI resins showed outstanding long‐term stability at high temperature with low mass loss and increased fracture toughness after aging at 200 °C. This work provides a novel insight into the development of molding compounds based on polymer blends system with excellent high‐temperature properties. © 2018 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2018, 56, 2412–2421
Psychological distress, role, and identity changes in mothers following a diagnosis of cancer: A systematic review
Authors: Kuswanto Carissa Nadia , Stafford Lesley , Sharp Jessica , Schofield Penelope 
Published: October 2018

AbstractObjectiveTo systematically review findings of the impact of cancer diagnosis and treatment on mothers' psychological well‐being, roles, and identity and to explore the psychosocial factors that contribute to mothers' psychological well‐being.MethodsSix databases were searched for research articles and theses exploring the association between the impact of cancer diagnosis and treatment on mothers' psychological well‐being, identity, and role, and the psychosocial factors contributing to mothers' psychological distress regardless of their cancer type and stage. The Mixed‐Method Appraisal Bias Tool was used to assess the selected studies' methodological quality.ResultsA total of 30 qualitative, quantitative, and mixed‐method studies were deemed eligible for inclusion. Most studies reported that mothers experienced significant psychological distress, changes to or loss of parenting efficacy, maternal identity, and role. Psychosocial factors that contributed to mothers' distress included mothers' young age, presence of metastases, lower parenting efficacy, fear of cancer recurrence, higher illness intrusiveness, and lack of appropriate support. Four main themes emerged from the qualitative studies: psychological impact of cancer on mothers, changes in maternal identity and role, relationship changes and concerns for their children, and meaning‐making in cancer experience.ConclusionsChanges in mothers' psychological well‐being, role, and identity occurred across cancer diagnoses, treatment, and recovery trajectories. The evidence suggests that mothers may benefit from continued and tailored psychosocial support to cope with these challenges, even after treatment is completed. Further studies with improved methodological quality are needed to explore these issues in depth.
Rapid therapeutic advances in CFTR modulator science
Authors: Clancy John P. 
Published: October 2018

AbstractCystic fibrosis (CF) is an autosomal recessive genetic disease caused by variants in the gene encoding the cystic fibrosis transmembrane conduction regulator (CFTR) protein. Loss of CFTR function disrupts chloride, bicarbonate and regulation of sodium transport, producing a cascade of mucus obstruction, inflammation, pulmonary infection, and ultimately damage in numerous organs. Established CF therapies treat the downstream consequences of CFTR dysfunction and have led to steady improvements in patient survival. A class of drugs termed CFTR modulators has recently entered the CF therapeutic landscape. These drugs differ fundamentally from prior therapies in that they aim to improve the function of disease‐causing CFTR variants. This review summarizes the science behind CFTR modulators, including their targets, mechanism of action, clinical benefit, and future directions in the field. CFTR modulators have dramatically changed how CF is treated, validated CFTR as a therapeutic target, and opened the door to truly personalized therapies and treatment regimens.
“It is better to be safe 100 times than dead once.”—Mark Twain
Authors: Edwards Victor , Study Karen 
Published: October 2018

A number of major process incidents during the 1980s led the Occupational Safety and Health Administration (OSHA) to promulgate the process safety management regulation in 1992 (1). Those incidents and the anticipation of the new OSHA regulations energized the South Texas Section of American Institute of Chemical Engineers (AIChE), and eight other organizations including the AIChE Center for Chemical Process Safety (CCPS), to create the first process plant safety symposium (PPSS) in 1992. The symposium was held in Houston as a low‐cost and convenient training forum for the large community of engineers and scientists at regional chemical process plants and refineries. Approximately 700 people attended. Subsequently, the PPSS has evolved to become one of the four main tracks in AIChE's Global Congress on Process Safety.In the intervening years, 18 PPSSs have been held. The unique focus of these symposia has been on practices, perspectives, methods, and tools to improve process safety at the plant level. This article, presented at the 20th PPSS, reviews examples of how progress in process safety has been facilitated by these symposia. The article concludes with a look to the future for needed advances in process safety. © 2018 American Institute of Chemical Engineers Process Saf Prog 37: 452–458, 2018
Characterization of a peptide containing the major heparin binding domain of human hepatic lipase
Authors: Coady Breanne M. , Marshall Jenika D. , Hattie Luke E. , Brannan Alexander M. , Fitzpatrick Madeline N. , Hickey Kala E. , Wallin Stefan , Booth Valerie , Brown Robert J. 
Published: October 2018

Human hepatic lipase (hHL) is a cell surface associated enzyme that hydrolyzes triacylglycerols and phospholipids within circulating lipoproteins. We hypothesized that an amino acid sequence mimicking the major heparin binding domain (HBD) of hHL will displace hHL from cell surfaces. To test this hypothesis, we generated a recombinant protein of thioredoxin linked with a cleavable, tagged sequence containing amino acids 442 to 476 of the mature hHL sequence, which contains the major HBD of hHL. The recombinant protein associated with heparin‐sepharose, and its peak elution from heparin‐sepharose occurred in the presence of 0.5 M NaCl. We cleaved and purified the tagged sequence containing the HBD from the recombinant protein and tested the ability of the peptide to displace full‐length hHL from HEK‐293 cells. The peptide indeed displaced hHL from cell surfaces, while no significant displacement was observed in the presence of a peptide with a scrambled sequence. Finally, we obtained structural information for the peptide containing the HBD. 1H‐ and 15N‐NMR spectra of the peptide indicate the peptide is largely unstructured, although not completely random coil. The addition of heparin to the peptide induced some changes in chemical shift, suggesting changes in peptide structure and/or specific interactions with heparin. Molecular simulations confirm the largely unstructured nature of the isolated peptide, but they also indicate weak tendencies for both α‐ and β‐structure formation in different parts of the chain. Overall, these data provide a proof‐of‐principle for the use of mimetic peptides for the displacement of cell surface associated lipases.
Subunit mass analysis for monitoring multiple attributes of monoclonal antibodies
Authors: Liu Peiran , Zhu Xin , Wu Wei , Ludwig Richard , Song Hangtian , Li Ruojia , Zhou Jiping , Tao Li , Leone Anthony M. 
Published: October 2018

RationaleMulti‐Attribute Methods (MAMs) are appealing due to their ability to provide data on multiple molecular attributes from a single assay. If fully realized, such tests could reduce the number of assays required to support a product control strategy while providing equivalent or greater product understanding relative to the conventional approach. In doing so, MAMs have the potential to decrease development and manufacturing costs by reducing the number of tests in a release panel.MethodsIn this work, we report a MAM which is based on subunit mass analysis.ResultsThe MAM assay is shown to be suitable for use as a combined method for identity testing, glycan profiling, and protein ratio determination for co‐formulated monoclonal antibody (mAb) drugs. This is achieved by taking advantage of the high mass accuracy and relative quantification capabilities of intact mass analysis using quadrupole time‐of‐flight mass spectrometry (Q‐TOF MS). Protein identification is achieved by comparing the measured masses of light chain (LC) and heavy chain (HC) mAbs against their theoretical values. Specificity is based on instrument mass accuracy. Glycan profiling and relative protein ratios are determined by the relative peak intensities of the protein HC glycoforms and LC glycoforms, respectively. Results for these relative quantifications agree well with those obtained by the conventional hydrophilic interaction liquid chromatography (HILIC) and reversed‐phase LC methods.ConclusionsThe suitability of this MAM for use in a quality control setting is demonstrated through assessment specificity for mAb identity, and accuracy, precision, linearity and robustness for glycan profiling and ratio determination. Results from this study indicate that a MAM with subunit mass analysis has the potential to replace three conventional methods widely used for mAb release testing including identification assay, glycosylation profiling, and ratio determination for co‐formulated mAbs.
Microhabitat use of native fishes in the Kootenai River: A fine‐scale evaluation of large‐scale habitat rehabilitation efforts
Authors: Branigan Philip R. , Quist Michael C. , Shepard Bradley B. , Ireland Susan C. 
Published: October 2018

AbstractFish and microhabitat data were collected at 542 prepositioned electrofishing sites (surface area of each site = 4 m2) in the Kootenai River, Idaho, during 2014 and 2015 to evaluate small‐scale habitat use by fishes, as it relates to large‐scale habitat rehabilitation efforts. Samples were collected from a 12‐km braided segment of river that had received localized habitat rehabilitation treatments since 2011. Fish and microhabitat data were collected to investigate habitat drivers related to the occurrence and relative abundance of fishes. Each sampling location was selected at random and characterized as “treated” (i.e., rehabilitated) or “untreated” based on proximity to habitat treatments. Fishes sampled from backwaters composed 71% of the overall catch and 84% of the catch from locally untreated areas of the river. Species‐specific regression models suggested that water depth and current velocity influenced the occurrence and abundance of fishes. In particular, shallow habitats with low current velocities were important for small‐bodied native fishes and likely serve as important rearing areas for juvenile fish. These habitat conditions typically characterize backwater and channel‐margin habitats that are vulnerable to anthropogenic perturbation. Prioritizing process‐based rehabilitation of these areas in large, regulated rivers would allow natural channel‐forming processes for the benefit of native fishes.
Synthesis, Characterization and Photo Response Behaviour of InSe and CuInSe2 Nanostructures Using Tris(5‐methyl‐2‐pyridylselenolato)indium(III) as Molecular Precursor
Authors: Karmakar Gourab , Tyagi Adish , Wadawale Amey , Kedarnath Gotluru , Srivastava Amit P. , Betty Chirayath. A. , Singh Vishal 
Published: October 2018

AbstractThis report presents the synthesis of organoselenium compound {SeC5H3(Me‐5)N}2 (1) and corresponding derivative of In(III), [In{SeC5H3(Me‐5)N}3] (2) and their characterization by elemental analysis, heteronuclear NMR (1H, 13C, 77Se) spectroscopy and single crystal X‐ray diffraction. The utilization of In(III) complex as molecular precursor has been demonstrated for the preparation of rare cubic phase of InSe. The complex has also been used for the preparation of tetragonal CuInSe2. The crystal structure, phase purity, morphology and elemental composition of these nanostructures were evaluated by powder X‐ray diffraction and electron microscopic techniques. The effect of increase in temperature is manifested in the increase of particle size of InSe and morphological variation from sheet to polygon in case of CuInSe2. The optical band gap of the nanostructures as deduced from diffuse reflectance spectroscopy (DRS) found to be in the range 1.84‐1.75 eV for InSe and 1.99‐1.78 eV for CuInSe2 which are optimum for solar energy harvesting. The band gap values are blue shifted relative to their respective bulk counterparts indicating quantum confinement effect in the nanostructures. Both InSe and CuInSe2 nanostructures showed photo response with faster switching characteristics which makes them promising candidate for alternative low cost photon absorber material.