bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sharia motivation in Muslim tourism definition, is it matter?
Authors: Usman Hardius , Sobari Nurdin , Sari Lia Estika 
Published: September 2019

PurposeThis study aims to identify the terminology that is in accordance with the reality of Muslim tourism market, especially from the perspective of Sharia motivation, between Halal tourism and Islamic tourism; provide information on the special needs of Muslim travelers based on the dominant motivational differences; and find the impact of Sharia motivation and the special needs of Muslim tourists to their satisfaction.Design/methodology/approachThe target population in this study is Muslim traveler at least 18 years old who has been traveling throughout Indonesia. Paired samplet-Test, multivariate analysis of variance and the multiple linier regression are applied for data analysis.FindingsThis study finds that Sharia motivation is less dominant in encouraging Muslims to travel; Sharia motivation has no impact on the importance of Sharia transportation, generic transportation and generic activities; and the dominance of Sharia motivation does not affect Muslim tourist satisfaction. However, the dominance of Sharia motivation has an influence on the importance of Sharia accommodation and Sharia activities, where both variables have positive effect on satisfaction. In the end, this study concludes that it is better to use the concept of Halal tourism than Islamic tourism.Originality/valueThis paper investigates the term of Halal tourism and Islamic tourism that are still ambiguous; even some researchers consider that the definition of both is similar.
Rituximab therapy is more effective than cyclophosphamide therapy for Japanese patients with anti‐topoisomerase I‐positive systemic sclerosis‐associated interstitial lung disease
Authors: Ebata Satoshi , Yoshizaki Ayumi , Fukasawa Takemichi , Miura Shunsuke , Takahashi Takehiro , Sumida Hayakazu , Asano Yoshihide , Sato Shinichi 
Published: September 2019

AbstractSystemic sclerosis‐associated interstitial lung disease (SSc‐ILD) is the most frequent cause of death for SSc but there is still no sufficient treatment available. Although cyclophosphamide (CYC) therapy is a common treatment which has shown statistical efficacy against SSc‐ILD to date, its effects are temporary and not enough. Rituximab (RTX), the anti‐CD20 monoclonal antibody, has recently shown efficacy in many autoimmune diseases. In SSc‐ILD, RTX is also considered to be one of the novel treatment candidates. However, studies of SSc‐ILD in Japanese treated with RTX have only a few case reports. Therefore, in this study, we retrospectively compared nine patients treated with RTX and 30 patients treated with CYC to investigate the efficacy of RTX treatment for Japanese anti‐topoisomerase I‐positive SSc‐ILD patients. At the 24‐month evaluation, the improvement rates of percent predicted of forced vital capacity and percent predicted of diffusing capacity of the lung carbon monoxide in the RTX‐treated group were significantly higher than those in the CYC‐treated group (20.6 ± 8.8% vs 1.1 ± 3.9%; P < 0.05 and 34.0 ± 6.0% vs −1.5 ± 2.8%; P < 0.01, respectively). In addition, skin thickness scores also showed a marked improvement from 13.5 points before the start of treatment to 5.8 points after 24 months by RTX therapy (P < 0.05). These results suggest that RTX treatment is more effective for Japanese SSc‐ILD patients than CYC treatment. In the future, it is expected that large‐scale clinical trials will show the usefulness of RTX treatment for SSc‐ILD.
The global distribution and evolutionary history of the pT26‐2 archaeal plasmid family
Authors: Badel Catherine , Erauso Gaël , Gomez Annika L. , Catchpole Ryan , Gonnet Mathieu , Oberto Jacques , Forterre Patrick , Da Cunha Violette 
Published: September 2019

SummaryAlthough plasmids play an important role in biological evolution, the number of plasmid families well‐characterized in terms of geographical distribution and evolution remains limited, especially in archaea. Here, we describe the first systematic study of an archaeal plasmid family, the pT26‐2 plasmid family. The in‐depth analysis of the distribution, biogeography and host–plasmid co‐evolution patterns of 26 integrated and 3 extrachromosomal plasmids of this plasmid family shows that they are widespread in Thermococcales and Methanococcales isolated from around the globe but are restricted to these two orders. All members of the family share seven core genes but employ different integration and replication strategies. Phylogenetic analysis of the core genes and CRISPR spacer distribution suggests that plasmids of the pT26‐2 family evolved with their hosts independently in Thermococcales and Methanococcales, despite these hosts exhibiting similar geographic distribution. Remarkably, core genes are conserved even in integrated plasmids that have lost replication genes and/or replication origins suggesting that they may be beneficial for their hosts. We hypothesize that the core proteins encode for a novel type of DNA/protein transfer mechanism, explaining the widespread oceanic distribution of the pT26‐2 plasmid family.
Refining the prognosis of fetuses infected with Cytomegalovirus in the first trimester of pregnancy by serial prenatal assessment: a single‐centre retrospective study
Authors: Faure‐Bardon V , Millischer A‐E , Deloison B , Sonigo P , Grévent D , Salomon L , Stirnemann J , Nicloux M , Magny J‐F , Leruez‐Ville M , Ville Y 
Published: September 2019

ObjectiveTo define the predictive value (PV) of known prognostic factors of fetal infection with Cytomegalovirus following maternal primary infection <14 weeks of gestation, at different time points of pregnancy: the end of the second trimester; following prenatal magnetic resonance imaging (MRI) at 32 weeks of gestation; and using all ultrasound scans performed in the third trimester (US3rdT).DesignA retrospective study.SettingReference fetal medicine unit.PopulationSixty‐two fetuses infected <14 weeks of gestation.MethodsWe defined second‐trimester assessment (STA) as the combination of ultrasound findings <28 weeks of gestation and fetal platelet count at cordocentesis. Three groups were defined: normal, extracerebral, and cerebral STA.Main outcome measuresFor each group, the PV of STA alone, STA + MRI, and STA + US3rdT were assessed retrospectively. Outcome at birth and at follow‐up were reported.ResultsThe STA was normal, and with extracerebral and cerebral features, in 43.5, 42.0, and 14.5%, respectively. The negative PV of normal STA and MRI for moderate to severe sequelae was 100%. The residual risk was unilateral hearing loss in 16.7% of cases. Of pregnancies with cerebral STA, 44% were terminated. Following extracerebral STA, 48% of neonates were symptomatic and 30% had moderate to severe sequelae. In those cases, the positive and negative PV of MRI for sequelae were 33 and 73%, respectively. STA + US3rdT had a lower negative PV than MRI for symptoms at birth and for moderate to severe sequelae. Any false‐positive findings at MRI were mostly the result of hypersignals of white matter.ConclusionsSerial assessment in the second and third trimesters by ultrasound and MRI is necessary to predict the risk of sequelae occurring in 35% of pregnancies following fetal infection in the first trimester of pregnancy.Tweetable abstractSerial ultrasound prognostic assessment following fetal CMV infection in the 1st trimester is improved by MRI at 32 weeks.
Methylation‐Based Age Prediction Using Pyrosequencing Platform from Seminal Stains in Han Chinese Males
Authors: Li Luyao , Song Feng , Lang Min , Hou Jiayi , Wang Zheng , Prinz Mechthild , Hou Yiping 
Published: September 2019

AbstractVarious methods have been performed to predict an unknown individual's age from biological traces in forensic investigations. A considerably accurate age prediction for the semen donor can help narrow down the search in a sexual assault case. The aim of this study was to develop an assay for age prediction from seminal stains in Han Chinese males. We built a sperm‐specific linear regression model using bisulfite pyrosequencing. Validations were conducted with a Mean Absolute Deviation from the chronological age (MAD) of 4.219 years in liquid semen, 4.158 years in fresh seminal stains, 4.393 years in aged seminal stains, and 3.880 years in mixed stains, respectively. Furthermore, our strategy enables accurate age prediction using a forensic casework sample. The strategy indicated that we produced an accurate and reliable age prediction tool for the semen donors in Han Chinese males for forensic purposes.
Impact of early nausea on varenicline adherence and smoking cessation
Authors: Peng Annie R. , Swardfager Walter , Benowitz Neal L. , Ahluwalia Jasjit S. , Lerman Caryn , Nollen Nicole L. , Tyndale Rachel F. 
Published: September 2019

AbstractBackground and aimsVarenicline effectiveness may be related to the level of adherence, which might be reduced by adverse effects such as nausea. The aim of the study was to test a possible effect of nausea on smoking cessation outcomes mediated by adherence.DesignMediation path analysis.SettingMultiple sites within Canada and the United States.ParticipantsTreatment‐seeking smokers receiving varenicline from two smoking cessation clinical trials: Quit2Live (NCT01836276; n = 449) and Pharmacogenetics of Nicotine Addiction Treatment (PNAT) (NCT01314001; n = 421).MeasurementsNausea severity was collected through self‐report and adherence was biologically assessed using varenicline concentrations (Quit2Live, plasma sample at week 4; PNAT, saliva sample at week 2). In Quit2Live, the end‐points were cotinine‐verified abstinence at weeks 4, 12 and 26. In PNAT, the end‐points were carbon monoxide‐verified abstinence at weeks 2, 12 and 26.FindingsEarly nausea was not directly associated with abstinence [odds ratio (OR) ranging from 0.73–1.28; P ≥ 0.26]. However early nausea was indirectly associated with lower cessation rates at multiple timepoints (ORs ranging from 0.92–0.94; 95% CI between 0.83–0.99) in a relationship mediated by reduced varenicline adherence (assessed by plasma varenicline concentrations) in the primary trial (Quit2Live). This relationship between nausea, adherence and cessation was similar in direction but weaker in effect size (ORs ranging from 0.98–0.99; 95% CI between 0.90–1.03) in a secondary trial (PNAT), where adherence was assessed using salivary varenicline concentrations.ConclusionsThese data suggest that early nausea during varenicline treatment may be indirectly associated with lower likelihood of smoking cessation through reducing varenicline adherence. Differences in robustness between the trials may be due to the different biological matrices (plasma vs. saliva) and/or timing used to assess varenicline adherence. The results of the first study suggest that improved management of early nausea during varenicline treatment may positively impact smoking cessation success through increasing varenicline adherence.
Late‐onset hypogonadism: metabolic impact
Authors: Grossmann M. , Ng Tang Fui M. , Cheung A. S. 
Published: September 2019

AbstractBackgroundObesity and dysglycemia (comprising insulin resistance, the metabolic syndrome and type 2 diabetes), that is diabesity, are associated with reduced circulating testosterone and, in some men, clinical features consistent with androgen deficiency.ObjectiveTo review the metabolic impact of late‐onset hypogonadism.MethodsComprehensive literature search with emphasis on recent publications.ResultsObesity is one of the strongest modifiable risk factors for late‐onset hypogonadism, and coexisting diabetes leads to further hypothalamic‐pituitary‐testicular axis suppression. The hypothalamic‐pituitary‐testicular axis suppression is functional and hence potentially reversible, and occurs predominantly at the level of the hypothalamus. While definitive mechanistic data are lacking, the evidence suggests that hypothalamic‐pituitary‐testicular axis suppression is mediated by dysregulation of pro‐inflammatory cytokines leading to hypothalamic inflammation. Dysregulation of central leptin and insulin signaling may also contribute. In contrast, recent data challenge the paradigm that estradiol excess is a major contributor to hypothalamic‐pituitary‐testicular axis suppression. Instead, relative estradiol signaling deficiency may contribute to metabolic dysregulation in men with diabesity. While weight loss and optimization of comorbidities can reverse functional hypothalamic‐pituitary‐testicular axis suppression, testosterone treatment leads to metabolically favorable changes in body composition and to improvements in insulin resistance.DiscussionThe relationship between diabesity and late‐onset hypogonadism is bidirectional. Preliminary evidence suggests that, in carefully selected men, lifestyle measures and testosterone treatment may have additive effects.ConclusionsWhile recent research has provided new insights into mechanistic and clinical aspects of diabesity‐associated late‐onset hypogonadism, more evidence from well‐designed large trials is needed to guide the optimal clinical approach to such men.
Narratives of Transfer, Dependence, and Resistance: Rastafarian Perspectives on US Colonialism in the Virgin Islands
Authors: Benard Akeia A. F. 
Published: September 2019

AbstractIn 1917, the United States purchased the Virgin Islands—and the people living on them—for $25 million from Denmark. The US Virgin Islands is currently one of 16 remaining non‐self‐governing territories in the world. This political (and necessarily) economic status is fundamentally identical to the “colony.” The territorial status of the Virgin Islands severely hampers the human rights and social, economic, and political potential and autonomy of the dependents of the Virgin Islands. My work focuses on the ways in which Rastafarians on St. Croix, USVI resist, negotiate, accommodate, and internalize their dependent territorial status and the ways in which they critique Western cultural, economic, and political imperialism through historical narrative, personal history, and political commentary during ritual reasonings or sessions. Much of the following article is in narrative form, so that Rastas can speak on colonialism and hegemony in their own words.
Emotions of Felt Memories: Looking for Interplay of Emotions and Histories in Iranian Political Consciousness Since Iran–Iraq War (1980–1988)
Authors: Saramifar Younes 
Published: September 2019

AbstractEmotions and feelings overwhelm mnemonic practices of any collective with traces of violence in its history. The violent history has become the means for the Iranian regime to regulate the nation's political consciousness. The regime formulates the political consciousness by way of politics of memory and enforcing a master narrative drawn from Shi'i history. I trace elicited emotions, within the war veterans’ memoirs, to explain feelings and consciousness in the realm of situated bodies. By way of those emotions, the article outlines an anthropology of emotions that rejects universal codes of emotions and instead proposes following an embodied consciousness through emotions along with histories that evoke them. My argument broadens Sarah Ahmed's idea of history and emotions to arrive at the assemblage of mnemonic practices in post‐war Iran and advocate a historically informed anthropology of emotions.
Low physical activity and higher use of screen devices are associated with myopia at the age of 16‐17 years in the CCC2000 Eye Study
Authors: Hansen Mathias Hvidtfelt , Laigaard Poul Pedersen , Olsen Else Marie , Skovgaard Anne Mette , Larsen Michael , Kessel Line , Munch Inger Christine 
Published: September 2019

AbstractPurposeTo determine the myopia prevalence in a Danish cohort aged 16–17 years and its relation to physical activity and use of screen‐based electronic devices.MethodsThe Copenhagen Child Cohort 2000 Eye Study is a prospective, population‐based, observational study. Information about use of screen devices and physical activity was obtained using questionnaires. Myopia was defined as non‐cycloplegic subjective spherical equivalent refraction ≤−0.50 D in right eye.ResultsWe included 1443 participants (45% boys) with a median age (±IQR) of 16.6 years (±0.3). The prevalence of myopia was 25% (CI95% 23–28, n = 360) with no differences between sexes (p = 0.10).The odds ratio (OR) for myopia was 0.57 (CI95% 0.42–0.76, p = 0.0002) in participants physically active 3–6 hr/week (n = 502) and 0.56 (CI95% 0.42–0.76, p = 0.0002) if active >6 hr/week (n = 506), both compared with participants physically active <3 hr/week (n = 396).The use of screen devices >6 hr/day was associated with increased OR for myopia compared with screen device use <2 hr/day in both weekdays (OR = 1.95, CI95% 1.16–3.30, p = 0.012) and weekends (OR = 2.10, CI95% 1.17–3.77, p = 0.013).ConclusionIn this cohort of healthy 16–17‐year olds, lower physical activity and more use of screen devices contributed significantly to the observed 25% prevalence of myopia with a roughly doubled risk of having myopia if physically active <3 hr/week or if using screen devices >6 hr/day. Our results support physical activity being a protective factor and near work a risk factor for myopia in adolescents.
Prevalence of macular complications related to myopia – Results of a multicenter evaluation of myopic patients in eye clinics in France
Authors: Leveziel Nicolas , Marillet Simon , Dufour Quentin , Lichtwitz Olivier , Bentaleb Yacine , Pelen François , Ingrand Pierre , Bourne Rupert 
Published: September 2019

AbstractPurposeUncorrected refractive errors are the first cause of vision impairment worldwide. High myopia is a frequent cause of sight‐threatening chorioretinal complications. The aim of this study was to evaluate the prevalence of macular complications, visual impairment and blindness in patients with myopia.MethodsA cross‐sectional multicenter study carried out in French eye clinics mainly dedicated to refractive errors. Myopia severity was defined as mild (−0.5 to −3 D), moderate (−3 to −6 D), high (−6 to −10 D) and very high (more than −10 D). Macular complications related to myopia included lacquer cracks, myopic choroidal neovascularization, chorioretinal atrophy and retinoschisis. The prevalences of macular complications, blindness and vision impairment were estimated with respect to degree of myopia and age. Eligibility criteria were myopia on the left eye of −0.5 D or more. Exclusion criteria included any missing data related to subjective refractive error, age, gender and any history of cataract or refractive surgery.ResultsData files from 198 641 myopic individuals with a mean age of 34 years (SD: 15 years) were analysed. The prevalence of mild, moderate, high and very high myopia was, respectively, 65.95%, 26.14%, 6.72% and 1.19%. The prevalence of macular complications in the high and very high myopia groups was 0.5% [0.39–0.64] and 4.27% [3.49–5.17]. The prevalence of blindness or vision impairment was observed in 10.10% [8.91–11.39%] of the very high myopic group. At 60 years old or over, the prevalences of blindness or vision impairment were, respectively, 9.75% [7.91–11.85%] and 25.71% [21.00–30.87%] in the high and very high myopia groups.ConclusionsThis multicenter cross‐sectional study provides new insights in terms of prevalence of macular complications related to myopia. To our knowledge, this is one of the largest European studies focusing on individuals with myopia, particularly on the macular complications and the functional consequences in relation to myopia.
Shiga toxin 2eB‐transgenic lettuce vaccine is effective in protecting weaned piglets from edema disease caused by Shiga toxin‐producing Escherichia coli infection
Authors: Hamabata Takashi , Sato Toshio , Takita Eiji , Matsui Takeshi , Imaoka Taishi , Nakanishi Nobuo , Nakayama Keizo , Tsukahara Takamitsu , Sawada Kazutoshi 
Published: September 2019

AbstractPorcine edema disease (ED) is a toxemia that is caused by enteric infection with Shiga toxin 2e (Stx2e)‐producing Escherichia coli (STEC) and is associated with high mortality. Since ED occurs most frequently during the weaning period, preweaning vaccination of newborn piglets is required. We developed stx2eB‐transgenic lettuce as an oral vaccine candidate against ED and examined its protective efficacy using a piglet STEC infection model. Two serially developed Stx2eB‐lettuce strains, 2BN containing ingredient Stx2eB constituting a concentration level of 0.53 mg Stx2eB/g of powdered lettuce dry weight (DW) and 2BH containing ingredient Stx2eB constituting a concentration level of 2.3 mg of Stx2eB/g of powdered lettuce DW, were evaluated in three sequential experiments. Taken the results together, oral administration of Stx2eB‐lettuce vaccine was suggested to relieve the pathogenic symptoms of ED in piglets challenged with virulent STEC strain. Our data suggested that Stx2eB‐lettuce is a promising first oral vaccine candidate against ED.
What determines the sustainability of community‐based palliative care operations? Perspectives of the social work professionals
Authors: Abdul Azeez E.P. , Anbu Selvi G. 
Published: September 2019

AbstractThe palliative care services are least operational in India with exception to the State of Kerala where the movement is widespread. Kerala's model of palliative care is known for its community‐based approach and efforts in universalizing the access. This model is unique in the domains of sustainability and mode of interventions. Cognate to the palliative care interventions worldwide, social workers play a crucial role in the service delivery of palliative care interventions in Kerala too. In this context, the present study attempted to explore the determinants of sustainable community‐based palliative care operations from the perspectives of professional social workers. The study adopted a descriptive qualitative research design using an in‐depth interview method. Interviews were conducted with 12 professional social workers engaged in community‐based palliative care delivery in the northern and central region of Kerala, India. The interviews were audio‐taped, transcribed, and further analyzed applying thematic analysis method. Five major themes, holistic care, community participation, volunteerism, resource mobilization, and socio‐political environment, were emerged from the data manifesting as the determinants of successful palliative care interventions. The result of the study has implications for the policymakers, public health professionals, and social workers who are involved in the development of similar models.