bluuebunny/crossref_metadata_2025_split huggingface dataset:
Increased levels of antibodies to synaptopodin and annexin 1 in patients with primary podocytopathies
Authors: Chebotareva Natalia V. , Charionovskaya Evgeniya A. , Biryukova Evgenia A. , Vinogradov Anatoliy A. , Alentov Igor I. , Sergeeva Natalia S. , Kononikhin Alexey S. , Nikolaev Evgeny N. , Moiseev Sergey V. 
Published: October 2024

IntroductionCirculating anti-podocyte antibodies have been proposed as potential factors contributing to increased permeability in primary podocytopathies, such as Minimal Change Disease (MCD) and Focal Segmental Glomerulosclerosis (FSGS). The aim of the study was to to assess the levels of antibodies targeting synaptopodin and annexin 1 in the blood serum of patients diagnosed with nephrotic syndrome, with the aim of evaluating their potential utility in diagnosing primary podocytopathies and predicting therapeutic response.MethodsThe study included a total of 72 patients diagnosed with nephrotic syndrome, alongside 21 healthy subjects for comparison. Among the patients, 38 were diagnosed with FSGS, 12 with MCD, and 22 with MN. The levels of anti-synaptopodin and anti-annexin-1 antibodies were quantified using Enzyme-Linked Immunosorbent Assay.ResultsThe levels of antibodies to annexin 1 and anti-synaptopodin in the blood were found to be higher in patients diagnosed with MCD and FSGS compared to those with MN and healthy individuals. The elevated levels of antibodies to annexin 1 and synaptopodin showed area under the curve values of 0.826 (95% CI 0.732–0.923) and 0.827 (95% CI 0.741–0.879), respectively. However, a model incorporating both antibodies demonstrated higher sensitivity (80.9%) and specificity (81.3%) with an AUC of 0.859 (95% CI 0.760-0.957). Notably, serum levels of annexin 1 and anti-synaptopodin antibodies did not predict the response to prednisolone and/or CNI therapy.DiscussionLevels of antibodies targeting synaptopodin and annexin 1 were notably elevated in patients diagnosed with MCD and FSGS compared to those with MN and healthy controls. A panel comprising both antibodies demonstrated moderate to high sensitivity and specificity for diagnosis MCD or FSGS.
Orthostatic intolerance with tachycardia (postural tachycardia syndrome) and without (hypocapnic cerebral hypoperfusion) represent a spectrum of the same disorder
Authors: Novak Peter , Systrom David M. , Witte Alexandra , Marciano Sadie P. 
Published: October 2024

BackgroundSpectrum of chronic orthostatic intolerance without orthostatic hypotension includes postural tachycardia syndrome (POTS), with orthostatic tachycardia and hypocapnic cerebral hypoperfusion (HYCH), without orthostatic tachycardia. This study compared autonomic, cerebrovascular, and neuropathic features of POTS and HYCH.MethodsThis retrospective study evaluated patients with orthostatic intolerance referred for autonomic testing. Analyzed data included surveys (Survey of Autonomic Symptoms, Compass-31, Neuropathy Total Symptom Score-6, Central Sensitization Inventory) and autonomic tests (Valsalva maneuver, deep breathing, sudomotor and tilt tests), cerebrovascular (cerebral blood flow velocity (CBFv) monitoring in the middle cerebral artery), respiratory (capnography), neuropathic (skin biopsies for assessment of small fiber neuropathy) and invasive cardiopulmonary exercise testing (iCPET).ResultsA total of 127 HYCH, 125 POTS, and 42 healthy controls were analyzed. Compared HYCH to POTS patients, there was no difference in the duration of symptoms, the prevalence of younger women, comorbidities, sensory and autonomic complaints, central sensitization syndrome, supine/standing norepinephrine levels, inflammatory markers and medical therapy except for gastrointestinal medication. Autonomic testing showed widespread but similar abnormalities in POTS and HYCH that included: reduced orthostatic CBFv and end-tidal CO2, preload failure (assessed in 16/19 POTS/HYCH), mild autonomic failure, and frequent small fiber neuropathy.ConclusionHYCH and POTS are syndromes of orthostatic intolerance with cerebral hypoperfusion associated with reduced orthostatic cerebral blood flow, hypocapnia, mild autonomic failure and small fiber neuropathy of a similar degree and distribution; except for tachycardia in POTS. Similarities in peripheral domain abnormalities that affect heart rate suggest that orthostatic tachycardia in POTS is driven by the central nervous system overcompensation of orthostatic challenge. These findings provide additional evidence that HYCH and POTS represent a spectrum of the same disorder. Reduced orthostatic cerebral blood flow is a key unifying feature of HYCH and POTS.
Multi-source domain adaptation for EEG emotion recognition based on inter-domain sample hybridization
Authors: Wu Xu , Ju Xiangyu , Dai Sheng , Li Xinyu , Li Ming 
Published: October 2024

BackgroundElectroencephalogram (EEG) is widely used in emotion recognition due to its precision and reliability. However, the nonstationarity of EEG signals causes significant differences between individuals or sessions, making it challenging to construct a robust model. Recently, domain adaptation (DA) methods have shown excellent results in cross-subject EEG emotion recognition by aligning marginal distributions. Nevertheless, these methods do not consider emotion category labels, which can lead to label confusion during alignment. Our study aims to alleviate this problem by promoting conditional distribution alignment during domain adaptation to improve cross-subject and cross-session emotion recognition performance.MethodThis study introduces a multi-source domain adaptation common-branch network for EEG emotion recognition and proposes a novel sample hybridization method. This method enables the introduction of target domain data information by directionally hybridizing source and target domain samples without increasing the overall sample size, thereby enhancing the effectiveness of conditional distribution alignment in domain adaptation. Cross-subject and cross-session experiments were conducted on two publicly available datasets, SEED and SEED-IV, to validate the proposed model.ResultIn cross-subject emotion recognition, our method achieved an average accuracy of 90.27% on the SEED dataset, with eight out of 15 subjects attaining a recognition accuracy higher than 90%. For the SEED-IV dataset, the recognition accuracy also reached 73.21%. Additionally, in the cross-session experiment, we sequentially used two out of the three session data as source domains and the remaining session as the target domain for emotion recognition. The proposed model yielded average accuracies of 94.16 and 75.05% on the two datasets, respectively.ConclusionOur proposed method aims to alleviate the difficulties of emotion recognition from the limited generalization ability of EEG features across subjects and sessions. Though adapting the multi-source domain adaptation and the sample hybridization method, the proposed method can effectively transfer the emotion-related knowledge of known subjects and achieve accurate emotion recognition on unlabeled subjects.
End-of-life management of multiple myeloma patients in the era of CD38 and immunotherapy
Authors: Sesques Pierre , Karlin Lionel , Massy Emmanuel , Maarek Alizée , Aussedat Guillaume , Lazareth Anne , Golfier Camille , Bouafia-Sauvy Fadhela , Lequeu Helene , Ghergus Dana , Safar Violaine , Ferrant Emmanuelle , Bachy Emmanuel , Ghesquières Hervé , Confavreux Cyrille B. , Demangel Delphine , Perrial Emeline , Dumontet Charles 
Published: October 2024

BackgroundIn spite of spectacular advances in the treatment of multiple myeloma, a majority of patients will die from this disease or related complications. While a great amount of focus has been dedicated to the development of novel therapies, little attention has been paid to latter stages of patient follow-up.Patients and methodsIn order to describe patient management during this critical period as well as the immediate causes and circumstances of death, we have analyzed a single center series of 100 patients diagnosed with myeloma who died between 2016 and 2021.ResultsPatients received a median of 3 lines of treatment, including 2 during their last year of life. Sixty per cent of patients had received daratumumab. Fifty patients had obtained complete remission or very good partial response at some time during the course of disease but 75 were refractory to the last treatment line. Eighteen patients died while their disease was stable or in remission while 77 had confirmed progressive disease at time of death. Thirty six patients had uncontrolled sepsis, 49 were in renal failure and 24 had hypercalcemia at the time of death. Seventy three patients presented with lymphopenia. Disease progression was documented in a majority of MM patients at the time of death and was associated with disease-related complications in a significant number of patients.ConclusionDisease progression remains the main cause of death in patients with multiple myeloma.
Grading of clear cell renal cell carcinoma by using monoexponential, biexponential, and stretched exponential diffusion-weighted MR imaging
Authors: Wang Wenhui , Wang Lingdian , Zhou Jing , Liu Taiyuan , Bai Yan , Wang Meiyun 
Published: October 2024

ObjectivesTo evaluate the diagnostic accuracy of monoexponential, biexponential and stretched-exponential diffusion-weighted imaging (DWI) models in the grading of clear cell renal cell carcinoma (ccRCC).Materials and MethodsFifty-one patients with pathologically proven ccRCC underwent DWI with fifteen b factors (0, 10, 30, 50, 70, 100, 150, 200, 300, 400, 600, 800, 1000, 1500, 2000 sec/mm²) on a 3.0T MR scanner. The isotropic apparent diffusion coefficient (ADC), true diffusion coefficient (ADCslow), pseudodiffusion coefficient (ADCfast), and fraction of perfusion (f) were derived from DWI using a biexponential model. The water diffusion heterogeneity index (α) and distributed diffusion coefficient (DDC) were derived from DWI using a stretched-exponential model. All values were calculated for the solid area of tumors and compared between high-grade and low-grade ccRCC. The Mann−Whitney U test and receiver operating characteristic (ROC) analysis were used for statistical analysis. The DeLong test was performed to compare the ROC curves.ResultsThe mean ADC, DDC, ADCslow and α values were significantly lower in high-grade ccRCC than in low-grade ccRCC (P&lt; 0.01). However, the ADCfast and f were not significantly different between the two groups (P &gt; 0.05). According to the ROC analyses, the AUC for α was 0.941, which was significantly greater than those of the other parameters, with a sensitivity of 100% and a specificity of 84.2%. The DeLong test showed that there were significant differences in the ROCs among ADCfast/ADC, ADCfast/α, f/ADCslow, ADCfast/ADCslow, f/α, DDC/α, and f/ADC.ConclusionsDiffusion-related parameters (ADC, DDC, ADCslow and α) could be used to distinguish between low- and high-grade ccRCC. The α derived from the stretched-exponential model may be the most promising parameter for grading ccRCC.
Isatin improves oligoasthenospermia caused by busulfan by regulating GSH/GPX4 axis to inhibit ferroptosis
Authors: Wang Chengniu , Wang Weizhen , Dong Jin , Li Xiaoran , Ye Taowen , Zeng Fanshuo , Jiang Mingyu , Shi Jianwu , Wang Xiaorong , Zhang Lei 
Published: October 2024

IntroductionFerroptosis, induced by iron overload and an imbalance in redox homeostasis, promotes the generation of reactive oxygen species (ROS), leading to iron-dependent lipid peroxides (LPO) and oxidative stress. Lipid peroxidation induced by reactive oxygen species is essential for the progression of spermatogenesis. However, its imbalance can lead to reproductive system damage and oligoasthenospermia, a critical cause of oligoasthenospermia. Isatin (ISA) is a naturally occurring compound that is widely distributed in lobsters, crustaceans, shellfish and various plants. It exhibits significant antioxidant and anti-aging properties, suggesting its potential as a therapeutic agent for the treatment of oligoasthenospermia. This study aimed to investigate the effects and mechanisms of ISA on oligoasthenospermia and to elucidate the underlying molecular pathways.MethodsAll mice were divided into normal group, model group and treatment group. Both model group and treatment group received a single intraperitoneal injection of 30 mg/kg BUS to create the model of oligoasthenospermia. After 2 weeks, the treatment group received different doses of 25, 50 and 100 mg/kg ISA by gavage for 28 days, and then mice were sacrificed and tested.ResultsThe results demonstrated that ISA effectively reversed busulfan-induced reproductive system damage in mice. This included the restoration of testicular histomorphology, improvement in sperm concentration and motility, regulation of serum sex hormone levels, and normalization of various oxidative indices in testicular tissue. Furthermore, ISA successfully reversed testicular ferroptosis by restraining the translocation of nuclear factor erythroid 2-related factor 2 (NRF2) into the nucleus and improved oligoasthenospermia through the glutathione (GSH)/glutathione peroxidase 4 (GPX4) axis.DiscussionISA was found to effectively ameliorate oligoasthenospermia in mice, presenting a potential therapeutic option for patients with this condition.
Influence of Hydration and Temperature on the NaxCO2 Based Transducer Voltage
Authors: Zărnescu George-Claudiu , Lavasani Esmaeil Jalali , Pîslaru-Dănescu Lucian , Stamatin Ioan 
Published: October 2024

This paper presents an experimental approach to maximizing the voltage generated by NaxCoO2 and improving the overall efficiency of the p-type thermoelectric leg by doping with Na up to x = 0.88. Two samples with different geometries were tested, each measured with and without an additional magnetic field applied in the direction of the temperature gradient. The properties of sodium cobaltite in response to hydration were explored, at temperatures between 300 and 380 K. Water injection boosted the current and power up to 75–100 µW at a temperature of 350–360 K. This power boost can be attributed to an electron-ion fluid flow pattern maintained by the longitudinal thermomagnetic effect and by water molecules forming hydrogen bonds with oxygen atoms in the CoO2 layers, inside the material. An electronic circuit was designed to boost the voltage to the desired level, for three or more sodium cobaltite samples mounted in parallel, and to store the energy in a supercapacitor. The output voltage and resistivity change of sodium cobaltite samples can be readily used as a humidity and temperature-sensing element in a transducer when paired with an appropriate electronic conditioning scheme.
Estados Unidos e China
Authors: Tonelo Iuri , De Paula Barbieri André Augusto 
Published: October 2024

O artigo buscar analisar o fenômeno da reestruturação produtiva em curso à luz da análise da principal potência internacional, os Estados Unidos, e da forte potência emergente no mundo oriental, a China. Parte-se de compreender que a crise financeira de 2008 deu lugar a mudanças econômicas a partir da grande recessão e novas disputas geopolíticas, o que tem levado também a novas configurações no mundo do trabalho. Dessa forma, o artigo analisa como a reestruturação produtiva tem se desenvolvido nos dois países, tanto do ponto de vista da implementação da indústria 4.0 e a plataformização do trabalho, quanto por compreender as formas de resistência em ambos, incluindo novos fenômenos de sindicalização, de antagonização à intensificação do trabalho, como o quiet quitting e great resignation, a ligação com pautas de opressão (como movimento como o Black Lives Matter) a partir do movimento operário e o aumento de greves, na manufatura e na indústria de serviços. A partir disso, buscamos mostrar as dificuldades para a estabilização dessas formas de estruturação produtiva – incompatíveis com a harmonização social – cujo curso vai depender, em grande parte, da atuação do movimento operário nesses dois países.
ЛИТЕРАТУРНЫЙ ОБЗОР СОВРЕМЕННОГО СОСТОЯНИЯ СИСТЕМЫ ДОПОЛНИТЕЛЬНОГО ОБРАЗОВАНИЯ В ПОДГОТОВКЕ ВРАЧЕЙ ПЕРВИЧНОЙ МЕДИКО-САНИТАРНОЙ ПОМОЩИ
Authors: М.К. Камбарова , Ж.Д. Брыжахина 
Published: October 2024

В статье представлены результаты систематического литературного поиска публикаций и других доступных источников отражающих состояние системы дополнительного образования в подготовке врачей первичной медико-санитарной помощи. Основная масса публикаций была проиндексирована в базах данных PubMed, MEDLINE, CINAHL, Embase, e-library, Google Scholar. Глубина поиска составила более 30 лет.
The article presents the results of a systematic literature search of publications and other available sources reflecting the status of the system of additional education in the training of doctors of primary health care. The bulk of publications were indexed in the databases PubMed, MEDLINE, CINAHL, Embase, e-library, Google Scholar. Search depth was more than 30 years.
Мақалада алғашқы медициналық көмек көрсететін дәрігерлерге арналған, жүйелі әдебиет бойынша басылымдардан іздестірумен алынған және қосымша білім беру жүйесінің жағдайын көрсететін басқа қол жетімді ақпараттардан алынған нәтижелер ұсынылды. Негізгі басылымдардың бөлігі PubMed, Medline, CINAHL, EMBASE, e-library, Google Scholar деректер қорында индекстелген. Іздеу кезеңі 30 жылдан астам болды.
АНАЛИЗ НОМИНАЛЬНЫХ И РАНГОВЫХ ПЕРЕМЕННЫХ ДАННЫХ С ИСПОЛЬЗОВАНИЕМ ПРОГРАММНОГО ОБЕСПЕЧЕНИЯ STATISTICA И SPSS
Authors: А.М. Гржибовский , С.В. Иванов , М.А. Горбатова 
Published: October 2024

В настоящей работе представлены общие сведения о выполнении статистического анализа данных, описываемыхноминальными и ранговыми переменными, с использованием программного обеспечения Statistica 10 и SPSS 20. Рассматриваются критерии хи-квадрат Пирсона, поправка Йейтса, точный критерий Фишера, а также батарея статистических критериев для анализа ранговых переменных. Настоящая статья призвана дать общие сведения об анализе качественных данных, и не заменяет прочтения специализированной литературы по статистике и клинической эпидемиологии.
This is the sixth paper of a series of articles where we describe basic principles of statistical data analysis using Statistica and SPSS software for beginners. Step-be-step algorithms for Pearson chi-square test and various tests for qualitative data are presented. The main aim of this paper is to provide basic knowledge on qualitative data analysis with practical examples using popular software. The article complements, but does not substitute specialized literature on biostatistics and clinical epidemiology.
Осы жұмыста Statistica 10 және SPSS 20 бағдарламалық қамсындандыруды қолданумен номиналды және рангілік ауыспалылармен сипатталған мәліметтердің статистикалық талдауын орындау туралы жалпы мәліметтер берілген. Пирсонның хи-квадрат, Йейтстің түзетуі Фишердің нақты критерилері, сол сияқты рангілік ауыспалыларды талдау үшін статистикалық критерилер батареясы қарастырылады. Осы мақала сапалы мәліметтерді талдау туралы жалпы мәліметтер беруге талап етілген және статистика және клиникалық эпидемиология бойынша мамандандырылған әдебиетті оқудың орнын толтырмайды.
ПСИХОЛОГИЧЕСКИЕ ОСОБЕННОСТИ ЛИЦ ПОЖИЛОГО ВОЗРАСТА, СТРАДАЮЩИХ АЛЛЕРГИЧЕСКИМИ ЗАБОЛЕВАНИЯМИ
Authors: Э.Ш. Шаяхметова , Л.М. Матвеева , А.Л. Линтварев , С.С. Матвеев 
Published: October 2024

В статье представлен анализ психологических особенностей лиц пожилого возраста, страдающих аллергическими заболеваниями. Исследование проводилось на базе ГБУЗ РБ № 1. В обследовании приняли участие 60 пациентов в возрасте 55-60 лет. Для решения исследовательский задач использован комплекс опросных методик, направленных на выявление психологических особенностей лиц с аллергическими расстройствами. В результате исследования было установлено, что пациентам с аллергическими патологиями свойственны такие психологические особенности, как тревожность, ригидность, эмоционально окрашенные жалобы по поводу физического самочувствия. Практическая значимость исследования заключается в том, что знание психологических особенностей и факторов, вызывающих аллергические заболевания, будут способствовать улучшению прогноза терапии и адекватному лечению.
The article presents an analysis of the psychological characteristics of elderly people suffering from allergic diseases. The study was conducted on the basis of the polyclinic 1. The survey involved 60 patients aged 55-60 years. To solve the research tasks, a set of survey techniques aimed at identifying the psychological characteristics of people with allergic disorders was used. As a result of the study, it was found that patients with allergic pathologies are characterized by such psychological features as anxiety, rigidity, emotionally colored complaints about physical well-being. The practical significance of the study lies in the fact that knowledge of psychological characteristics and factors causing allergic diseases will contribute to improving the prognosis of therapy and adequate treatment.
МЕТОДИЧЕСКИЕ ПОДХОДЫ К ИСПОЛЬЗОВАНИЮ ПСИХОФИЗИОЛОГИЧЕСКИХ ПАРАМЕТРОВ ДЛЯ ОЦЕНКИ ЭФФЕКТИВНОСТИ ПОИСКА ИНФОРМАЦИИ ПОДРОСТКАМИ В ИНТЕРНЕТЕ
Authors: Е.И. Николаева , Н.В. Сутормина 
Published: October 2024

Поиск информации в интернете считает одной из важнейших компетенций, которыми должен владеть современный подросток. При этом не хватает объективных психофизиологических критериев, которые могли бы продемонстрировать соответствие результатов поиска внутренним усилиям человека, прикладываемым для решения поставленной задачи. Задача данной работы состояла в поиске психофизиологических коррелятов эффективного поиска информации в интернете. Для первоначального анализа из многочисленных параметров ЭЭГ были выбраны спектральная мощность наиболее принятых диапазонов. Эти результаты сопоставлялись с эффективностью тормозных процессов, окулографии, латеральными предпочтениями. В качестве испытуемых были 45 подростков (средний возраст 13,7±2,1 лет); из них 18 девочек и 27 мальчиков. Для исследования биоэлектрической активности мозга был использован итальянский электроэнцефалограф BE Plus PRO (64 каналов). Тормозный контроль оценивался в парадигме go/go и go/no-go. Рабочая память оценивалась с помощью авторской методики О. М. Разумниковой. Латеральные предпочтения измерялись с помощью набора проб. Была выявлена тенденция снижения мощностей медленных ритмов (в диапазонах дельта и тета) и повышение мощности бета-ритмов после поиска информации в интернете, по сравнению с мощностями этих ритмов до начала поиска в интернете. Факторный анализ выявил связь между эффективностью поиска информации в интернете и ведущим глазом. Эти данные требуют дополнительных исследований.
Search for information on the Internet At the same time, no objective psychophysiological findings were found that could lead to a quick identification of internal disorders in a person applied to the task. Task This work has occupied the search for psychophysiological correlates of effective search for information on the Internet. For the initial analysis, the spectral power of the most accepted ranges was selected from numerous EEG parameters. These results were compared with the effectiveness of inhibitory processes, oculography, and lateral preferences. The subjects were 45 adolescents (mean age 13.7±2.1 years); of them 18 girls and 27 boys. An Italian electroencephalograph BE Plus PRO (64 channels) was used to study the electrical activity of the brain. Braking control was assessed in the go/go and go/no-go paradigm. Working memory was assessed using O.M. Razumnikova. Lateral preferences were measured using a set of trials. There was a tendency to decrease in the power of slow rhythms (in the delta and theta ranges) and an increase in the power of beta rhythms after searching for information on the Internet compared to the powers of these rhythms before starting to search on the Internet. Factor analysis revealed a relationship between the effectiveness of searching for information on the Internet and the leading eye. These data require additional research. K