bluuebunny/crossref_metadata_2025_split huggingface dataset:
SKRIPS v1.0: a regional coupled ocean–atmosphere modeling framework (MITgcm–WRF) using ESMF/NUOPC, description and preliminary results for the Red Sea
Authors: Sun Rui , Subramanian Aneesh C. , Miller Arthur J. , Mazloff Matthew R. , Hoteit Ibrahim , Cornuelle Bruce D. 
Published: October 2019

Abstract. A new regional coupled ocean–atmosphere model is developed and its implementation is presented in this paper. The coupled model is based on two open-source community model components: the MITgcm ocean model and the Weather Research and Forecasting (WRF) atmosphere model. The coupling between these components is performed using ESMF (Earth System Modeling Framework) and implemented according to National United Operational Prediction Capability (NUOPC) protocols. The coupled model is named the Scripps–KAUST Regional Integrated Prediction System (SKRIPS). SKRIPS is demonstrated with a real-world example by simulating a 30 d period including a series of extreme heat events occurring on the eastern shore of the Red Sea region in June 2012. The results obtained by using the coupled model, along with those in forced stand-alone oceanic or atmospheric simulations, are compared with observational data and reanalysis products. We show that the coupled model is capable of performing coupled ocean–atmosphere simulations, although all configurations of coupled and uncoupled models have good skill in modeling the heat events. In addition, a scalability test is performed to investigate the parallelization of the coupled model. The results indicate that the coupled model code scales well and the ESMF/NUOPC coupler accounts for less than 5 % of the total computational resources in the Red Sea test case. The coupled model and documentation are available at https://library.ucsd.edu/dc/collection/bb1847661c (last access: 26 September 2019), and the source code is maintained at https://github.com/iurnus/scripps_kaust_model (last access: 26 September 2019).
WHAT-IF: an open-source decision support tool for water infrastructure investment planning within the water–energy–food–climate nexus
Authors: Payet-Burin Raphaël , Kromann Mikkel , Pereira-Cardenal Silvio , Strzepek Kenneth Marc , Bauer-Gottwein Peter 
Published: October 2019

Abstract. Water infrastructure investment planning must consider
the interdependencies within the water–energy–food nexus. Moreover,
uncertain future climate, evolving socio-economic context, and stakeholders
with conflicting interests, lead to a highly complex decision problem.
Therefore, there is a need for decision support tools to objectively
determine the value of investments, considering the impacts on different
groups of actors, and the risks linked to uncertainties. We present a new
open-source hydro-economic optimization model, incorporating in a holistic
framework, representations of the water, agriculture, and power systems. The model represents the joint development of nexus-related infrastructure and policies and evaluates their economic impact, as well as the risks linked to uncertainties in future climate and socio-economic development. We apply the methodology in the Zambezi River basin, a major African basin shared by eight countries, in which multiple investment opportunities exist, including new hydropower plants, new or resized reservoirs, development of irrigation agriculture, and investments into the power grid. We show that it is crucial to consider the links between the different systems when evaluating the impacts of climate change and socio-economic development, which will ultimately influence investment decisions. We find that climate change could induce economic losses of up to USD 2.3 billion per year in the current system. We show that the value of the hydropower development plan is sensitive to future fuel prices, carbon pricing policies, the capital cost of solar technologies, and climate change. Similarly, we show that the value of the irrigation development plan is sensitive to the evolution of crop yields, world market crop prices, and climate change. Finally, we evaluate the opportunity costs of restoring the natural floods in the Zambezi Delta; we find limited economic trade-offs under the current climate, but major trade-offs with irrigation
and hydropower generation under the driest climate change scenario.
PRODUCTIVE REGIONAL CONCENTRATION IN THE STATE OF PARANÁ: CASE STUDY OF NON-WOOD FOREST PRODUCTS
Authors: Corrêa Bittencourt Keila , De Paula Thiago Rodrigues , Juazeiro dos Santos Anadalvo , Tuyoshi Hosokawa Roberto , Hoeflich Vitor Afonso 
Published: October 2019

The non-wood forest products (NWFPs) have significant productive potential in the State of Paraná, Brazil. In this paper we analyzed the five NWFPs most representative in the state:. Yerba mate, Palmito (Pupunha, Juçara and Real), Pinion, Resin and Latex. The results showed that although many municipalities participate at some level in their production, there are concentration when analyzing the Paraná mesoregions. That is, there is a concentration of production in the middle region west andsoutheast to the Yerba Mate, in the Curitiba metropolitan middle region for the production of Palmito and all mesoregions have a significant production of pinion. The Curitiba metropolitan mesoregion participates with most of theproduction of resin and mesoregion Northwest with the highest production of latex. The importance of the study comes of the lack of public policies to assist, direct and oversee the production and marketing of NWFPs, which generates a suboptimal result from the point of sustenaible develompment. In conclusion it has to be a regional analysis using Quotient Locational, both for production and for the production value, has proved a valuable tool to characterize the Paraná mesoregions about their participation in the production of non wood forest products in the State of Paraná and to identify the productive potential of NWFPs. Thus, current and future actions os state government and all other stakeholders in order development regional into may make use of this analysis as part of its planning, in order to allow society to benefit from the development of NWFPs in the state.
Archivos familiares y cultura escrita en los albores de la Edad Contemporánea
Authors: Fernández Valdivieso José Luis 
Published: October 2019

El presente trabajo pretende poner en valor los archivos familiares como fuente de investigación para la cultura escrita en los siglos XVIII y XIX. Para ello, el autor reflexiona sobre las posibilidades que ofrecen los archivos de las medianas oligarquías, muy numerosos y desconocidos, a la par que mal organizados, tomando como referencia el Archivo de los Marqueses de Corvera, aglutinado en torno al linaje de los Bustos, que a su vez contiene diversos archivos de familias de diferentes niveles sociales. Se presta especial atención a la transmisión de la cultura escrita en el seno del linaje a través de las mandas testamentarias, el uso profesional de la cultura escrita en las administraciones familiares y el nivel cultural de las diferentes clases sociales relacionadas con dichas administraciones, que se observa fundamentalmente en la correspondencia, las cuentas presentadas por los administradores y los inventarios de bienes de las viviendas.
The present work intends to value the family archives as a source of research for the written culture in the XVIII and XIX centuries. For this, the author reflects on the possibilities offered by the archives of the medium oligarchies, very numerous and unknown, at the same time poorly organized, taking as reference the Archive of the Marquises of Corvera, united around the lineage of the Bustos, which in turn contains various files of families of different social levels. Special attention is paid to the transmission of written culture within the lineage through testamentary trusts, the professional use of written culture in family administrations and the cultural level of the different social classes related to these administrations, which it observes mainly in the correspondence, the accounts presented by the administrators and the inventories of goods of the houses.
Fluctuation and diversity of Hydromedusae (Hydrozoa, Cnidaria) in a highly productive region of the Gulf of Mexico inferred from high frequency plankton sampling
Authors: Pruski Sarah , Miglietta Maria Pia 
Published: October 2019

Hydrozoa medusae undergo blooms and seasonal fluctuations; however the drivers of such fluctuations are unknown. To understand how medusa populations fluctuate in response to seasonal factors such as temperature, salinity, dissolved oxygen, and chlorophyll a, and to enhance our taxonomic knowledge of Hydrozoa in Galveston Bay (TX), we performed frequent plankton sampling from September 2015 to September 2016. We collected 1,321 medusae in 190 sampling days. Using molecular barcoding and morphological analyses we identified 25 species, of which 21 are a first record for Galveston Bay and eight for the Gulf of Mexico. Daily medusa abundance is non-linearly related to temperature, with peak abundance estimated with multivariate regression analysis at approximately 21C. The role that temperature plays in driving medusa abundance has implications for future climate change scenarios, given that temperature in the Gulf of Mexico is expected to rise 4 °C by the end of the century. We also show that the biodiversity of the Galveston Bay and the Gulf of Mexico is underestimated and that molecular barcoding is an important and efficient tool to identify large number of medusae. We conclude that dense plankton sampling is necessary to capture both diversity and abundance of planktonic medusae.
A Simple Electrode‐Level Chemical Presodiation Route by Solution Spraying to Improve the Energy Density of Sodium‐Ion Batteries
Authors: Liu Xiaoxiao , Tan Yuchen , Liu Tongchao , Wang Wenyu , Li Chunhao , Lu Jun , Sun Yongming 
Published: October 2019

AbstractThe formation of a solid electrolyte interface (SEI) on the surface of a carbon anode consumes the active sodium ions from the cathode and reduces the energy density of sodium‐ion batteries (SIBs). Herein, a simple electrode‐level presodiation strategy by spraying a sodium naphthaline (Naph‐Na) solution onto a carbon electrode is reported, which compensates the initial sodium loss and improves the energy density of SIBs. After presodiation, an SEI layer is preformed on the surface of carbon anode before battery cycling. It is shown that a large irreversible capacity of 60 mAh g−1 is replenished and 20% increase of the first‐cycle Coulombic efficiency is achieved for a hard carbon anode using this presodiation strategy, and the energy density of a Na0.9[Cu0.22Fe0.30Mn0.48]O2||carbon full cell is increased from 141 to 240 Wh kg−1 by using the presodiated carbon anode. This simple and scalable electrode‐level chemical presodiation route also shows generality and value for the presodiation of other anodes in SIBs.
Diffusion Limitation of Lithium Metal and Li–Mg Alloy Anodes on LLZO Type Solid Electrolytes as a Function of Temperature and Pressure
Authors: Krauskopf Thorben , Mogwitz Boris , Rosenbach Carolin , Zeier Wolfgang G. , Janek Jürgen 
Published: October 2019

AbstractThe morphological instability of the lithium metal anode is the key factor restricting the rate capability of lithium metal solid state batteries. During lithium stripping, pore formation takes place at the interface due to the slow diffusion kinetics of vacancies in the lithium metal. The resulting current focusing increases the internal cell resistance and promotes fast lithium penetration. In this work, galvanostatic electrochemical impedance spectroscopy is used to investigate operando the morphological changes at the interface by analysis of the interface capacitances. Therewith, the effect of temperature, stack pressure, and chemical modification is investigated. The work demonstrates that introducing 10 at% Mg into the lithium metal anode can effectively prevent contact loss. Nevertheless, a fundamental kinetic limitation is also observed for the Li‐rich alloy, namely the diffusion controlled decrease of the lithium metal concentration at the interface. An analytical diffusion model is used to describe the temperature‐dependent delithiation kinetics of Li–Mg alloys. Overall, it is shown that different electrode design concepts should be considered. Mg alloying can increase lithium utilization, when no external pressure is applied while pure lithium metal is superior for setups that allow stack pressures in the MPa range.
A prospective, multicenter study of low dose decitabine in adult patients with refractory immune thrombocytopenia
Authors: Zhou Hai , Qin Ping , Liu Qiang , Yuan Chenglu , Hao Yunliang , Zhang Haiyan , Wang Zhencheng , Ran Xuehong , Chu Xiaoxia , Yu Wenzheng , Wang Xin , Hou Yu , Peng Jun , Hou Ming 
Published: October 2019

AbstractWe conducted a prospective, multicenter study to evaluate the efficacy and safety of low‐dose decitabine in adult patients with refractory immune thrombocytopenia. Adult patients who did not respond to, did not tolerate, or were unwilling to undergo splenectomy, with either a baseline platelet count less than 30 × 109/L or the presence of bleeding symptoms and further need of ITP‐specific treatments, were enrolled. Patients received decitabine at 3.5 mg/m2 intravenously for three consecutive days per cycle, for three cycles with a four‐week interval between cycles. All patients were assessed every week during the first 12 weeks and at four‐week intervals thereafter. We screened 49 patients for eligibility. Four patients were excluded and 45 received decitabine. At the end of decitabine treatment, complete response was achieved in eight patients (17.78%), and partial response was achieved in 15 patients (33.33%). The median time to initial response was 28 days (range, 14‐70 days). Furthermore, seven relapsed patients received decitabine retreatment and all showed platelet response, including one complete response and six partial responses. Sustained response rates at 6, 12 and 18 months were 44.44% (20/45), 31.11% (14/45) and 20.0% (9/45), respectively. For responders, immune thrombocytopenia‐related symptoms, fatigue, psychological health, fear, and overall quality of life were significantly improved. Adverse events were observed in 13 (28.89%) patients. No serious adverse events were recorded. In conclusion, low dose decitabine is potentially effective and safe in the management of adults with refractory immune thrombocytopenia. This trial is registered with clinicaltrials.gov identifier: NCT01568333.
Discovery of a Potent GLUT Inhibitor from a Library of Rapafucins by Using 3D Microarrays
Authors: Guo Zufeng , Cheng Zhiqiang , Wang Jingxin , Liu Wukun , Peng Hanjing , Wang Yuefan , Rao A. V. Subba , Li Ruo‐jing , Ying Xue , Korangath Preethi , Liberti Maria V. , Li Yingjun , Xie Yongmei , Hong Sam Y. , Schiene‐Fischer Cordelia , Fischer Gunter , Locasale Jason W. , Sukumar Saraswati , Zhu Heng , Liu Jun O. 
Published: October 2019

AbstractGlucose transporters play an essential role in cancer cell proliferation and survival and have been pursued as promising cancer drug targets. Using microarrays of a library of new macrocycles known as rapafucins, which were inspired by the natural product rapamycin, we screened for new inhibitors of GLUT1. We identified multiple hits from the rapafucin 3D microarray and confirmed one hit as a bona fide GLUT1 ligand, which we named rapaglutin A (RgA). We demonstrate that RgA is a potent inhibitor of GLUT1 as well as GLUT3 and GLUT4, with an IC50 value of low nanomolar for GLUT1. RgA was found to inhibit glucose uptake, leading to a decrease in cellular ATP synthesis, activation of AMP‐dependent kinase, inhibition of mTOR signaling, and induction of cell‐cycle arrest and apoptosis in cancer cells. Moreover, RgA was capable of inhibiting tumor xenografts in vivo without obvious side effects. RgA could thus be a new chemical tool to study GLUT function and a promising lead for developing anticancer drugs.
Atomic‐Scale Visualization of the Stepwise Metal‐Mediated Dehalogenative Cycloaddition Reaction Pathways: Competition between Radicals and Organometallic Intermediates
Authors: Zhang Chi , Kazuma Emiko , Kim Yousoo 
Published: October 2019

AbstractDehalogenative cycloaddition reaction is a powerful strategy to generate new ring scaffolds with π‐conjugated features on a surface, and thus holds great promise toward atomically precise electronic devices or nanomaterials. The ortho‐dihalo substitution provides a good strategy to realize cycloaddition. However, the limited understanding of intermediate states involved hinders mechanistic exploration for further precise design and optimization of reaction products. Now, the evolutions of competing surface‐stabilized radicals and organometallic intermediates in real space were visualized toward the formation of dominant conjugated four‐membered ring connections. From the interplay of scanning tunneling microscopy and density functional theory calculations, the stepwise metal‐mediated dehalogenative cycloaddition pathway is elucidated both experimentally and theoretically. The results provide fundamental insights into the intermediate states involved in on‐surface synthesis.
Di‐tert‐butyldiphosphatetrahedran: Katalytische Synthese des freien Phosphaalkin‐Dimers
Authors: Hierlmeier Gabriele , Coburger Peter , Bodensteiner Michael , Wolf Robert 
Published: October 2019

AbstractDie Tetrahedrane sind eine bisher nur wenig entwickelte Verbindungsklasse und insbesondere ist mit AsP3 bisher nur ein einziges neutrales, heteroatomares Tetrahedran bekannt. Hier berichten wir über die Synthese eines neutralen, molekularen X2Y2‐Tetraeders (X, Y=p‐Blockelemente), der gleichzeitig das erste Beispiel des seit langem postulierten freien Phosphaalkindimers ist. Di‐tert‐butyldiphosphatetrahedran, (tBuCP)2, lässt sich aus dem Monomer tBuCP in einer nickelkatalysierten Dimerisierungsreaktion unter Verwendung von [(NHC)Ni(CO)3] (NHC=1,3‐Bis(2,4,6‐trimethylphenyl)imidazolin‐2‐yliden (IMes) bzw. 1,3‐Bis(2,6‐diisopropylphenyl)imidazolin‐2‐yliden (IPr)) als Katalysator darstellen. Die Einkristallröntgenstrukturanalyse eines Silber(I)‐komplexes bestätigt die tetraedrische Struktur. Der Einfluss des N‐heterocyclischen Carbenliganden auf die katalytische Reaktion wird diskutiert und auf Basis von synthetischen, kinetischen und quantenmechanischen Untersuchungen wird ein möglicher Bildungsmechanismus vorgestellt.
Enantioselective Dearomatization of Indoles by an Azoalkene‐Enabled (3+2) Reaction: Access to Pyrroloindolines
Authors: Mei Guang‐Jian , Tang Xiwen , Tasdan Yildiz , Lu Yixin 
Published: October 2019

AbstractThe enantioselective dearomatization of indoles by an organocatalytic (3+2) reaction has been established. The reaction makes use of simple indole derivatives as substrates, and employs azoalkenes reaction partners. A wide range of pyrroloindolines containing an all‐carbon quaternary stereogenic center were readily prepared in high yields and with excellent enantioselectivities.
Water‐Induced Growth of a Highly Oriented Mesoporous Graphitic Carbon Nanospring for Fast Potassium‐Ion Adsorption/Intercalation Storage
Authors: Qian Yong , Jiang Song , Li Yang , Yi Zheng , Zhou Jie , Tian Jie , Lin Ning , Qian Yitai 
Published: October 2019

AbstractA highly oriented mesoporous graphitic carbon nanospring (OGCS) with graphitic layers that are perpendicular to the axis is prepared by hydrothermal treatment of epoxy resin at 500 °C and annealing at 1400 °C. Water plays an important role in not only forming the graphitic carbon nanospring with a high [002] orientation and a large amount of active edge‐plane sites, but also in the generation of the mesoporous structure, which facilitate fast K‐ion adsorption and diffusion. In situ and ex situ measurements confirm that OGCS undergoes K‐adsorption in mesopores and then K‐intercalation in the graphite layer to form KC8 with a low discharge voltage. The spring‐like nanostructure can expand one‐dimensionally along the axial direction to accommodate the volume variation. The OGCS electrode thus shows a much better K‐storage performance than that of unoriented graphitic carbon.
Not Limited to Iron: A Cobalt Heme–NO Model Facilitates N–N Coupling with External NO in the Presence of a Lewis Acid to Generate N2O
Authors: Abucayon Erwin G. , Khade Rahul L. , Powell Douglas R. , Zhang Yong , Richter‐Addo George B. 
Published: October 2019

AbstractSome bacterial heme proteins catalyze the coupling of two NO molecules to generate N2O. We previously reported that a heme Fe–NO model engages in this N−N bond‐forming reaction with NO. We now demonstrate that (OEP)CoII(NO) similarly reacts with 1 equiv of NO in the presence of the Lewis acids BX3 (X=F, C6F5) to generate N2O. DFT calculations support retention of the CoII oxidation state for the experimentally observed adduct (OEP)CoII(NO⋅BF3), the presumed hyponitrite intermediate (P.+)CoII(ONNO⋅BF3), and the porphyrin π‐radical cation by‐product of this reaction, and that the π‐radical cation formation likely occurs at the hyponitrite stage. In contrast, the Fe analogue undergoes a ferrous‐to‐ferric oxidation state conversion during this reaction. Our work shows that cobalt hemes are chemically competent to engage in the NO‐to‐N2O conversion reaction.
Self‐Healable Solid Polymeric Electrolytes for Stable and Flexible Lithium Metal Batteries
Authors: Wu Na , Shi Ya‐Ru , Lang Shuang‐Yan , Zhou Jin‐Ming , Liang Jia‐Yan , Wang Wei , Tan Shuang‐Jie , Yin Ya‐Xia , Wen Rui , Guo Yu‐Guo 
Published: October 2019

AbstractThe key issue holding back the application of solid polymeric electrolytes in high‐energy density lithium metal batteries is the contradictory requirements of high ion conductivity and mechanical stability. In this work, self‐healable solid polymeric electrolytes (SHSPEs) with rigid‐flexible backbones and high ion conductivity are synthesized by a facile condensation polymerization approach. The all‐solid Li metal full batteries based on the SHSPEs possess freely bending flexibility and stable cycling performance as a result of the more disciplined metal Li plating/stripping, which have great implications as long‐lifespan energy sources compatible with other wearable devices.
Organoplatinum‐Substituted Polyoxometalate Inhibits β‐amyloid Aggregation for Alzheimer's Therapy
Authors: Zhao Jing , Li Kexin , Wan Kaiwei , Sun Tiedong , Zheng Nannan , Zhu Fanjiao , Ma Jichao , Jiao Jia , Li Tianchan , Ni Jinyuan , Shi Xinghua , Wang Hui , Peng Qiang , Ai Jing , Xu Wanhai , Liu Shaoqin 
Published: October 2019

AbstractAggregated β‐amyloid (Aβ) is widely considered as a key factor in triggering progressive loss of neuronal function in Alzheimer's disease (AD), so targeting and inhibiting Aβ aggregation has been broadly recognized as an efficient therapeutic strategy for curing AD. Herein, we designed and prepared an organic platinum‐substituted polyoxometalate, (Me4N)3[PW11O40(SiC3H6NH2)2PtCl2] (abbreviated as PtII‐PW11) for inhibiting Aβ42 aggregation. The mechanism of inhibition on Aβ42 aggregation by PtII‐PW11 was attributed to the multiple interactions of PtII‐PW11 with Aβ42 including coordination interaction of Pt2+ in PtII‐PW11 with amino group in Aβ42, electrostatic attraction, hydrogen bonding and van der Waals force. In cell‐based assay, PtII‐PW11 displayed remarkable neuroprotective effect for Aβ42 aggregation‐induced cytotoxicity, leading to increase of cell viability from 49 % to 67 % at a dosage of 8 μm. More importantly, the PtII‐PW11 greatly reduced Aβ deposition and rescued memory loss in APP/PS1 transgenic AD model mice without noticeable cytotoxicity, demonstrating its potential as drugs for AD treatment.