bluuebunny/crossref_metadata_2025_split huggingface dataset:
Essential oil composition and variability of Hypericum perforatum L. from wild population in Kosovo
Authors: Hajdari Avni , Mustafa Behxhet , Nebija Dashnor , Kashtanjeva Albana , Widelski Jaroslaw , Glowniak Kazimierz , Novak Johannes 
Published: March 2018

Abstract
Aerial parts of Hypericum perforatum L. (Hypericaceae) were collected from five wild populations in Kosovo, with aim to investigate the chemical composition and natural variation of essential oils between wild populations. This species could be considered of economic potential as it is widespread in Kosovo, on the other hand H. perforatum is one of the best-known medicinal herbs used in Kosovo folk medicine. Essential oils were obtained by steam distillation and analysed by GC-FID and GC-MS. Sixty-seven components were identified. The yields of essential oils differed depending on the population and ranged from 0.04 to 0.26% based on dry weight. The aerial parts of H. perforatum were characterized by the following main constituents: 2-methyl-octane (1.1-15.5%), α-pinene (3.7-36.5%), β-caryophyllene (1.2-12.4%), caryophyllene oxide (3.3-17.7%) and n-tetradecanol (3.6- 10.4%). Hierarchical cluster analysis revealed that the concentration of components depends on the origin of the plant populations, thus α-pinene and 2-methyl-octane were present in the highest concentration in population originating from Gjakove, Prizren and Ferizaj, whereas in the populations originating from Peje and Prishtine the most abundant constituents were caryophyllene oxide, β-caryophyllene and n-tetradecanol. Further investigation is needed to establish the natural variability and chemopolymorphism of this species in the territory of Kosovo, which should be supported by molecular level analyses.
Effect of N-(m-bromoanilinomethyl)-p-isopropoxyphenylsuccinimide on the anticonvulsant action of four classical antiepileptic drugs in the mouse maximal electroshock-induced seizure model
Authors: Luszczki Jarogniew J. , Marzeda Ewa , Kondrat-Wrobel Maria W. , Pyrka Daniel , Kocharov Sergey L. , Florek-Luszczki Magdalena 
Published: March 2018

Abstract
The purpose of this study was to determine the effects of N-(m-bromoanilinomethyl)- p-isopropoxyphenylsuccinimide (BAM-IPPS - a new succinimide derivative) on the protective action of four classical antiepileptic drugs (AEDs: carbamazepine [CBZ], phenobarbital [PB], phenytoin [PHT] and valproate [VPA]) in the mouse maximal electroshock (MES)-induced tonic seizure model. Tonic hind limb extension (seizure activity) was evoked in adult male albino Swiss mice by a current (sine-wave, 25 mA, 500 V, 50 Hz, 0.2 s stimulus duration) delivered via ear-clip electrodes. BAM-IPPS administered (i.p.) at a dose of 150 mg/kg significantly elevated the threshold for electroconvulsions in mice (P<0.05). Lower doses of BAM-IPPS (50 and 100 mg/kg) had no significant impact on the threshold for electroconvulsions in mice. Moreover, BAM-IPPS (100 mg/kg) did not significantly affect the anticonvulsant potency of CBZ, PB, PHT and VPA in the mouse MES model. BAM-IPPS elevated the threshold for electroconvulsions in mice in a dosedependent manner. However, BAM-IPPS (100 mg/kg) did not affect the anticonvulsant action of various classical AEDs in the mouse MES model, making the combinations of BAM-IPPS with CBZ, PB, PHT and VPA neutral, from a preclinical point of view.
Phenolic substances in Ailanthus glandulosa Desf
Authors: Pekala Karolina , Wawrzusiszyn Katarzyna , Bogucka-Kocka Anna 
Published: March 2018

Abstract
The aim of this work was the isolation and identification of phenolic acids from fruit and leaves of Ailanthus glandulosa Desf. The methods used in the isolation and identification of the compounds were: isolation of phenolic acids modified by Ibrahim and Towers, acidic and alkaline hydrolysis by Schmidtlein and Herrmann and identification of phenolic acids in the isolated fraction of two-dimensional thin layer chromatography (TLC) on cellulose plates. In the course of the study, the presence of phenolic acids in leaves and fruit of Ailanthus glandulosa Desf was confirmed. Overall, proportions of 15 phenolic acids were found and identified in the analyzed material. These are: gallic acid, ellagic acid, caffeic acid, gentisic acid, protocatechuic acid, p-hydroxybenzoic acid, m-hydroxybenzoic acid, ferulic acid, p-coumaric acid, syryngic acid, vanillic acid, salicylic acid, 2-hydroxy-4- methoxybenzoic acid, 2,5-dimethoxycinnamic, p-hydroxyphenylacetic acid, and 3 other compounds named A, B, C, whose identification was not possible due to the lack of suitable reference patterns. Studies have shown that leaves and fruit of the plant Ailanthus glandulosa Desf. contain a large number of phenolic acids which possess many important pharmacological activities.
The influence of proteasome inhibitor on the expression of cardiomyocytes damage markers after incubation with doxorubicin
Authors: Tereszkiewicz Sylwia , Matysiak Wlodzimierz , Mandziuk Slawomir , Korga Agnieszka , Oleksiejuk Malgorzata , Hejna Marcin , Korobowicz-Markiewicz Agnieszka , Iwan Magdalena , Dudka Jaroslaw 
Published: March 2018

Abstract
The aim of the study was to verify the thesis that the cardiotoxic effects of doxorubicin are connected with activation of the ubiquitin - proteasome pathway followed by protein degradation. The expression of myocardial damage markers - fatty acid binding protein (H-FABP) and brain natriuretic peptide (BNP) was evaluated in rat fetal cardiomyocytes simultaneously treated with doxorubicin and the proteasome inhibitor - bortezomib. The level of H-FABP and BNP protein under the influence of doxorubicin was decreased below the detection threshold with unchanged (H-FABP) or elevated (BNP) mRNA expression level. Against the expectations, the inhibitor of proteasome did not abolish this effect. The observed abnormal expression of BNP and H-FABP protein after doxorubicin treatment makes their diagnostic significance in anthracycline cardiotoxicity questionable.
The effect of hormone replacement therapy on the expression of the alkaline phosphatase gene (ALPL) within the mucosal epithelium of the cheek and in peripheral blood lymphocytes
Authors: Rahnama Mansur , Lobacz Michal , Szyszkowska Anna , Trybek Grzegorz , Kozicka-Czupkallo Maryla 
Published: March 2018

Abstract
In adult life, proper bone metabolism requires efficient regulation of bone formation and resorption processes. Bone turnover markers allow for assessing the rate of bone formation and resorption processes. In menopausal period, female patients experience gradual reduction in blood estradiol levels. The deficit of estrogens leads to enhanced osteoclastogenesis and bone resorption. Alkaline phosphatase (ALP) is a membranebound enzyme that stimulates the osteoblast activity and bone mineralization. It is synthesized by osteoblasts and incorporated into the newly formed bone tissue. The produced enzyme stimulates the osteoblast activity and bone mineralization. The goal of this study is to determine the effect of hormone replacement therapy in postmenopausal women on the expression of alkaline phosphatase gene (ALPL) within the mucosal epithelium of the cheek and in peripheral blood lymphocytes. The studies show that hormone replacement therapy has no significant effect on the increase in ALPL expression within the mucosal epithelium of the cheek. Only in women having undergone ovarectomy (OV), the epithelial ALPL expression level was higher than in the remaining groups.
Comparison of visual, impedance spectroscopy and laser fluorescence methods in detecting early carious lesions on occlusal surfaces
Authors: Chalas Renata , Wojcik-Checinska Ilona , Zubrzycka-Wrobel Joanna , Piatek Dominika , Bachanek Teresa 
Published: March 2018

Abstract
The diagnostic management is a very important and integral part of the entire treatment process and has a direct influence on the decision-taking on the choice of the most appropriate form of therapy consistent with current knowledge. Knowledge of the morphology of hard dental tissues lesions has led to the development of quantitative methods for diagnosis and monitoring of dental caries, which enabled the implementation of appropriate treatments aimed at repairing than replacing damaged tissue. The aim of the study was to compare selected diagnostic methods: visual (ICDAS), impedance spectroscopy (CarieScan PRO) and laser fluorescence (Diagnodent Pen) in detecting caries in grooves on the chewing surfaces of molars and premolars. The obtained results indicated a high concordance of measurements performed with the Diagnodent Pen with the results of visual examination and a lower compliance of visual examination with the results obtained using the CarieScan PRO. A combination of visual and tactile method with tests using advanced technology provides greater opportunity to confirm the diagnosis of carious lesions requiring medical intervention.
Different faces of a febrile state
Authors: Rymarz Ewa , Milaniuk Sylwia , Prystupa Andrzej , Mosiewicz Jerzy 
Published: March 2018

Abstract
Fever develops in various diseases. It is mainly associated with infectious diseases but can also occur in non-infectious ailments. Clinical symptoms are not always explicit, which can hinder the diagnosis and delay the institution of appropriate treatment. The aim of the study is to present difficulties in diagnosing the cause of a febrile state in a patient with splenic abscess.
Is there any benefit of harmonic scalpel for hemorrhoidectomy versus conventional diathermy?
Authors: Yıldırım Doğan , Dönmez Turgut , Aktürk Okan Murat , Kocakuşak Ahmet , Çakır Mikail , Yurtteri Mustafa Ertuğrul 
Published: March 2018

Aim: Symptomatic hemorrhoidal disease is among the most common surgical diseases and it may necessitate surgical intervention. The most common and effective approaches used for surgical treatment are harmonic scalpel hemorrhoidectomy and conventional diathermy excision. The aim of the study was to compare the outcomes of hemorrhoidectomy using harmonic scalpel and the conventional diathermy excision techniques. Methods: The files of 113 consecutively operated patients (26 females 23%, 87 males 77%), who were operated on for symptomatic Grade III–IV hemorrhoids, were retrospectively reviewed for length of operation and hospitalization, early and delayed bleeding, urinary retention, postoperative abscess and anal stenosis. Exclusion criteria were additional operations, recurrent cases and inflammatory bowel disease. Results: Conventional diathermy hemorrhoidectomy in 60 (53%) and harmonic scalpel hemorrhoidectomy were used in 53 patients (47%). There were significant differences between the operation and hospitalization times in favor of harmonic scalpel group (p&lt;0.05 for both). The other parameters did not show any significant differences (p&gt;0.05 for all). Conclusion: Harmonic scalpel hemorrhoidectomy is advantageous and superior to conventional diathermy hemorrhoidectomy in regard to shorter operation time and earlier discharge from the hospital with no additonal complications.
Propertis Psikometris Skala Sikap Terhadap Pelajaran Sosial Humaniora
Authors: Periantalo Jelpa 
Published: March 2018

The purpose of research was to assess psychometric properties of scale attitude toward social sciences subject: Economics, Sociology, History and Geography. Psychometric properties consisted of validity, reliability and item discrimination. The subjects were 198 high school students with purposive sampling method. Scale used semantic differensial format with overall 68 items. One item unpassed, 67 items passes selection with rit ≥ 0,400. Factorial validity confirmed 3 assumed factors: activity, evaluation and potential. Convergent validity showed positive correlation among subscale. The parallel test reliability showed of equivalent coefficient rxx’ 0,939. The final scale consisted of 12 items, easily in used and scoring. The scale could be used for research, external validation of other scale, high school majoring, educational counseling, learning evaluation, education intervension and university majoring. The next research was to validate with external criterion especially academic achievement.
CONSÓRCIOS INTERMUNICIPAIS PARA LICENCIAMENTO AMBIENTAL: UM INSTRUMENTO DE GARANTIA DO DIREITO FUNDAMENTAL À BOA ADMINISTRAÇÃO PÚBLICA
Authors: Da Silva Corralo Giovani , Moura da Silva Boanova Aline 
Published: March 2018

O meio ambiente remete à dicotomia entre desenvolvimento e sustentabilidade. No ordenamento brasileiro o protagonismo do município em questões desse tipo é inegável. O estudo tem por objetivo demonstrar que o consórcio intermunicipal para licenciamento ambiental é um importante instrumento de garantia do direito fundamental à boa administração pública. Especificamente abordaremos questões como: consórcios intermunicipais, direito ambiental, competências constitucionais e o licenciamento ambiental de interesse local descrito na Lei Complementar 140 de 2011. Como resultado concluímos que o consórcio intermunicipal para licenciamento ambiental é a melhor forma de garantir o direito fundamental à boa administração pública.
O (DES)ENVOLVIMENTO EDUCACIONAL E A PROFISSIONALIZAÇÃO – UM DEBATE VICERAL PARA O COENVOLVIMENTO
Authors: Silva Rafael Santos , Souza Karine Pinheiro de Souza Pinheiro 
Published: March 2018

O presente estudo apresenta uma discussão epistemológica sobre a profissionalização da educação, contrapondo com a necessidade de formar para além de adestrar operários para o mercado. Com isso, iniciamos com um debate quantitativo e crítico com base em dados primários e secundários brasileiros referentes aos indicadores de matrícula, ao orçamento executado pelo Ministério da Educação. Com o objetivo de debater o real papel da educação como instrumento do direito social básico, especificando nosso debate sobre o processo de (des)envolvimento da educação profissional, atrelado ao avanço da técnica pela técnica, num simples processo de industrialização da educação como corretor educativo via controle de conteúdo das determinações mercadológicas por meio da capacitação formal e não essencial. Numa abordagem crítica percebemos que o modelo de gestão se aproxima do modelo de ensino, e nos questionamos como o processo de (de)senvolvimento da educação está atrelado ao modelo de industrialização da educação? Diante desse contexto, apontamos para a força da tecnologia enquanto instrumento mobilizador de mudanças sociais quando associada ao Coenvolvimento, pode se configurar por meio de processos colaborativos e cooperativos e podem fazer emergir novas formas de aprender e ensinar rompendo com a mercantilização da Educação.
ENSINO MÉDIO NO ESTADO DO PARÁ
Authors: Ceccon Ellen Cristina 
Published: March 2018

Considera-se que a transferência de recursos públicos da educação para o setor privado caracteriza-se como processos de formas de privatização da educação básica. O objetivo deste trabalho é apresentar e analisar o volume de despesas com Manutenção e Desenvolvimento do Ensino (MDE) na etapa do Ensino Médio regular (MDE-EM), empreendido pelo governo do estado do Pará no período de 2005 a 2015, focalizando os recursos contingenciados para o setor privado inscritos nas categorias econômicas 3.33.90.39 – Outros Serviços de Terceiros – Pessoa Jurídica e 3.33.50.00 – Transferências a Instituições Privadas sem fins lucrativos. Pretende-se averiguar a representatividade destes gastos no total investido em MDE no Ensino Médio para verificação do fluxo de recursos públicos transferidos para o setor privado. Para o desenvolvimento da pesquisa, realizou-se um estudo de caso, qualitativo, por meio de fontes primárias. Para análise e levantamento dos dados financeiros utilizou-se informações disponibilizadas pelo Sistema de Informações sobre Orçamentos Públicos em Educação (Siope) nos relatórios contábeis do estado do Pará. O período da pesquisa corresponde ao período histórico que compreende os anos de 2005 a 2015, pois considera-se a vigência da Lei de Responsabilidade Fiscal (Lei Complementar n. º 101/2000) que institui normas de finanças públicas relacionadas à responsabilidade na gestão fiscal. Com o estudo, observou-se que o investimento em MDE no Ensino Médio aumentou no período analisado, e que os recursos transferidos para o setor privado nessa etapa, nas categorias econômicas analisadas, oscilam, apresentando picos de elevação e recuo no estado do Pará.
Inherited Diseases of Holstein Cattle: Story So Far in Turkey
Authors: AVANUS Kozet , ALTINEL Ahmet 
Published: March 2018

Inherited diseases are caused by recessive alleles proceed from increased inbreeding in Holstein cattle population. Bovine leucocyte adhesion deficiency (BLAD), deficiency of uridine monophosphate synthase enzyme (DUMPS), complex vertebral malformation (CVM), factor XI deficiency (FXID) and bovine citrulinaemia (BC) are the most frequent inherited diseases in Holstein cattle population. The prevalence for carriers of BLAD, DUMPS, CVM, FXID and BC diseases were reported highest in Denmark (21.5%), USA (1.2%), Japan (32.5%), Turkey (18%) and Australia (13%) respectively. Moreover the highest prevalence for carriers of BLAD, CVM and FXID were reported as 2.2%, 3.4% and 18% respectively in Turkey so far. Neither DUMPS nor BC carriers were identified in Turkey so far. However further studies are required in order to identify the provinces that have risks for mutant alleles of inherited diseases in Turkey. Determining the carrier animals and exclude them from breeding is the only solution for eradication studies of inherited diseases.
BİR İLETİŞİM BİÇİMİ OLARAK EVLİLİĞİN KÜLTÜREL, SİYASİ VE EKONOMİK UNSURLARI (GİRESUN ÖRNEĞİ)
Authors: GÜLTEPE Mustafa , ÖZKAN Selfiye 
Published: March 2018

Kültür, bireyin içinde yaşadığı
toplumun, inançları, değerleri, ekonomik siyasal düşünüşlerini de kapsayan bir
olgudur. Bu nedenle Levi-Strauss, kültürün uygar ya da barbar şeklinde
tanımlanmasına karşı çıkmaktadır. Ona göre her kültür pratiğinin ait olduğu
toplumda bir işlevi bulunmaktadır. Bu bağlamda kültür bireylerin ya da
grupların tarihsel, ekonomik, sosyal ilişkilerini düzenleyen kurallar
bütünüdür. Levi-Strauss “Akrabalık İlişkileri” adlı çalışması kapsamında
evliliğin farklı boyutları incelenmeye çalışılmıştır. Bu çalışmada
Levi-Strauss’un bu eserinden yola çıkılarak Giresun ilinde yaşayan 80 yaş üstü
bireylerle görüşülerek evlilik ilişkilerinin iletişimsel, kültürel, ekonomik ve
siyasi boyutları araştırılmıştır. Araştırmada veri toplama aracı olarak görüşme
tekniğinden yararlanılmıştır. Elde edilen veriler içerik analizi yöntemi
kapsamında kodlama tekniği ile çözümlenmiştir. Kültürel bir unsur olarak
evliliğin gerçekleşme sürecinde ne gibi uygulamalar olduğuna değinilerek bu
uygulamaların işlevleri üzerinde durulacaktır.
SİYASİ ALANDA DEMOKRATİKLEŞME HAREKETLERİNİN TOPLUMSAL ALANDAKİ REALİTESİ (1808 – 1908)
Authors: AGAHABALAEI FANID Nematollah , YILMAZER Derya 
Published: March 2018

Demokratikleşme sürecine Avrupa’ya
göre çok geç başlayan Osmanlı Devletinde demokratikleşme çabaları toplumsal
alanda yeteri kadar karşılığını bulamamış ve demokrasi kavramı halk için fazla
bir anlam ifade etmemiştir. Osmanlı devleti için demokratikleşme azınlıkları
devlet bünyesinde tutabilmek, dağılmayı engellemek için bir çare olarak
düşünülmüş ve genelde dış baskılar sonucu iç sorunların çözümü için bir araç
olarak kullanılmıştır. Tanzimat Döneminde aydın bir sınıfın oluşması basın yolu
ile kamuoyu yaratma çabaları umut verici olsa da Tanzime ve Islahat Fermanları
halk hareketlerinin değil saray bürokrasisinin çabaları sonucunda
gerçekleşmiştir. Halk hukuksal olarak kendisine verilen hakların çoğu zaman
farkına bile varmamıştır. Demokratik düşüncenin zayıf başarısı Kanun-i Esasi ile iki aşamalı da olsa bir
seçim sisteminin getirilmesidir. Fakat hemen ardından otuz yıl sürecek bir
istibdat yaşanması meşruti yönetimin halk tarafından benimsenmediğini gösterir.
İncelenen yüz yıllık sürecin en önemli sonucu 1908’de Anayasanın tekrar ilan
edilmesi ve 1909 değişiklikleridir. Milli Mücadeleyi gerçekleştiren ve
Cumhuriyeti kuran kadro bu süreçte yetişmiştir.
Factors Affecting the Efficiency of Inventory Management of Janapriya Multiple Campus, Pokhara
Authors: Bhandari Hari Bahadur 
Published: March 2018

Each and every organization needs inventories to perform day to day activities to achieve set objectives. This study entitled 'factors affecting the efficiency of inventory management of janapriya multiple campus, pokhara' is to assess the factors that affect on inventory management of the campus. Basically, the study is based on primary data including 21 sample out of total population 28. Stratified random sampling is used to select a sample size of 21 respondents. Structured questionnaire and other official documents are used to collect data from primary sources. Samples were three groups of office staff. Group wise distribution of sample was top level, middle level and assistant level. The collected data are tabulated and presented according to the needs and objectives of the study. Descriptive statistics of mean and standard deviation were used for data analysis. Factors related with proper record keeping of inventory, financial resources, skill possessed by store staff and bureaucratic procurement procedure positively affect on the effectiveness of inventory management. Proper inventory record, stock information and competent & qualified store employees are very important for the effectiveness of inventory management. Sufficient fund, skillful store clerks, training and development for store staff, few quality suppliers and easy process of budget release are inevitable for superior inventory management. Janapriya Journal of Interdisciplinary Studies, Vol. 6 (December 2017), page: 78-87
Normative human brain volume growth
Authors: Peterson Mallory , Warf Benjamin C. , Schiff Steven J. 
Published: March 2018

OBJECTIVEWhile there is a long history of interest in measuring brain growth, as of yet there is no definitive model for normative human brain volume growth. The goal of this study was to analyze a variety of candidate models for such growth and select the model that provides the most statistically applicable fit. The authors sought to optimize clinically applicable growth charts that would facilitate improved treatment and predictive management for conditions such as hydrocephalus.METHODSThe Weibull, two-term power law, West ontogenic, and Gompertz models were chosen as potential models. Normative brain volume data were compiled from the NIH MRI repository, and the data were fit using a nonlinear least squares regression algorithm. Appropriate statistical measures were analyzed for each model, and the best model was characterized with prediction bound curves to provide percentile estimates for clinical use.RESULTSEach model curve fit and the corresponding statistics were presented and analyzed. The Weibull fit had the best statistical results for both males and females, while the two-term power law generated the worst scores. The statistical measures and goodness of fit parameters for each model were provided to assure reproducibility.CONCLUSIONSThe authors identified the Weibull model as the most effective growth curve fit for both males and females. Clinically usable growth charts were developed and provided to facilitate further clinical study of brain volume growth in conditions such as hydrocephalus. The authors note that the homogenous population from which the normative MRI data were compiled limits the study. Gaining a better understanding of the dynamics that underlie childhood brain growth would yield more predictive growth curves and improved neurosurgical management of hydrocephalus.