bluuebunny/crossref_metadata_2025_split huggingface dataset:
La métaphore agricole : une clé herméneutique pour comprendre la relation homme-femme en Ben Sira 26,19-21
Authors: Lavoie Jean-Jacques 
Published: November 2024

Dans cet article, qui porte sur la version grecque de Sir 26,19-21, l’auteur cherche à répondre aux questions suivantes. Qui se cache derrière le mot allotriois au v. 19? S’agit-il de femmes adultères, de prostituées ou d’étrangères ? Comment faut-il comprendre la métaphore du v. 20 ? Du fait que cette métaphore est unique dans la Septante, doit-on y voir la trace d’une influence grecque ? Quel type de relation entre l’homme et la femme cette métaphore suppose-t-elle ? En somme, cet article vise à montrer que la métaphore agricole est une clé herméneutique qui permet de comprendre la relation homme-femme en Ben Sira 26,19-21.
Impact of Fingolimod Discontinuation Strategy on Recurrence of Disease Activity in Individuals With Multiple Sclerosis
Authors: Shalaby Nevin M. , Rushdi Rufaidah , Alroughany Raed , Ahmed Samar , Merghany Nahla , Shehata Hatem , Al-Hashel Jasem , Nada Mona , Gad Adel , Hassan Amr , Kishk Nirmeen , Hamdy Sherif , Abdelnaseer Maged , Hegazy Mohamed , Ahmed Sandra , Abdel-Aal Abdel-Rahman , El Shebawy Haidy 
Published: November 2024

ABSTRACT

BACKGROUND:
For individuals with multiple sclerosis (MS), treatment interruption can result in relapse/recurrence of the disease activity. Currently, there are no consensus guidelines about whether an abrupt stop with a short washout period or gradual tapering is better for fingolimod (Gilenya) cessation. We investigated the impact of the fingolimod discontinuation strategy on the recurrence of disease activity and the rebound occurrence of symptoms during washout.

METHODS:
This was a retrospective, observational, multicenter study of individuals with MS in Egypt and Kuwait. The charts of patients on fingolimod therapy were screened to collect data on the impact of drug cessation strategies on disease activity and relapse occurrence. Disease relapse after cessation was defined as a relapse that occurred in the previous 12 months despite using a first-line treatment option or 2 relapses in the previous 12 months.

RESULTS:
In a cohort of 100 patients, 58 had an abrupt cessation and 42 had a gradual tapering. Compared with abrupt cessation, gradual tapering was associated with a significantly lower rate of disease relapse (4.8% vs 81%, respectively; P = .001). Abrupt cessation also resulted in increased MRI findings of new lesions (24.1%; P = .29), enhancing lesions (32.8%; P = .5), and enlarging lesions (6.9%; P = .59); however, none of the MRI findings were significant. Other risk factors showed no significant association with disease relapse after fingolimod cessation.

CONCLUSIONS:
Gradual fingolimod tapering is highly recommended to decrease the risk of rebound and severe disease reactivation. A prolonged washout should be avoided for lymphocyte recovery.
The ideas of traditional Yakuts about animals reflected in folklore texts about clothing
Authors: Fedorova Aitalina Rodionovna 
Published: November 2024

This article presents the raw materials of Yakut clothing and its symbolic meaning based on the materials of Yakut traditional folklore (Olonkho texts, proverbs and sayings). In all cultures, archaic ideas about clothing are associated with sacred ideas about the surrounding world, space, apothecary, social, aesthetic meanings are put into the costume, and animals play an important role in this phenomenon, acting here not only as material resources, but also carrying mental content, endowing a garment with special meanings, and a person special qualities. The costume is in direct contact with the human biological body, which is perceived in all cultures not just as a biological object, but as something related to the human personality. The main text of the article is divided into two semantic parts: folklore data revealing the social significance and material value of animal skins, and ideas about the apotropaic, magical functions of animals transmitted to humans through clothing. Previous studies of the traditional Yakut costume have been devoted to issues of visual appearance, sacred functions, and costume transformation. In this article, an attempt will be made to consider the ideas of the Yakuts about animals reflected in the materials of traditional clothing, which is the novelty of the study. The considered ethnographic data, texts of epic folklore and Yakut proverbs and sayings showed that animal motifs in clothing definitely carry sacred functions: animal morphological motifs are used in Yakut traditional clothing not only for aesthetic, but also for apotropaic purposes. Proverbs and sayings, along with descriptions of the clothes of mythical characters of Olonkho, show that the ranking of valuable / not valuable, sacred /ordinary is reflected in everyday vocabulary and folklore. These data allow us to evaluate not only the attitude towards fur as a material, but through them we can trace the spiritual attitude towards animals expressed through the costume.
Balance training in older adults enhances feedback control after perturbations
Authors: Koster Ruud A. J. , Alizadehsaravi Leila , Muijres Wouter , Bruijn Sjoerd M. , Dominici Nadia , van Dieën Jaap H. 
Published: November 2024

Background
As we age, avoiding falls becomes increasingly challenging. While balance training can mitigate such challenges, the specific mechanisms through which balance control improves remains unclear.

Methods
We investigated the impact of balance training in older adults on feedback control after perturbations, focusing on kinematic balance recovery strategies and muscle synergy activation. Twenty older adults aged over 65 underwent short-term (one session) and long-term (3-weeks, 10 sessions) balance training, and their recovery from unpredictable mediolateral perturbations was assessed. Perturbations consisted of 8° rotations of a robot-controlled platform on which participants were balancing on one leg. We measured full-body 3D kinematics and activation of 15 leg and trunk muscles, from which linear and rotational kinematic balance recovery responses and muscle synergies were obtained.

Results
Our findings revealed improved balance performance after long-term training, characterized by reduced centre of mass acceleration and (rate of change of) angular momentum. Particularly during the later stage of balance recovery the use of angular momentum to correct centre of mass displacement was reduced after training, decreasing the overshoot in body orientation. Instead, more ankle torque was used to correct centre of mass displacement, but only for perturbations in medial direction. These situation and strategy specific changes indicate adaptations in feedback control. Activation of muscle synergies during balance recovery was also affected by training, specifically the synergies responsible for leg stiffness and ankle torques. Training effects on angular momentum and the leg stiffness synergy were already evident after short-term training.

Conclusion
We conclude that balance training in older adults refines feedback control through the tuning of control strategies, ultimately enhancing the ability to recover balance.
Support Vector Machines
Authors: Muñoz Alberto , Moguerza Javier M. , Martos Gabriel 
Published: February 2019

AbstractWe describe the central ideas of Support Vector learning. This includes the notion of learning from data via risk minimization and the notion of kernels as an efficient means of encoding prior information. We give an overview over the optimization problems arising from SV classification, regression, quantile estimation and combination of information. Moreover, we discuss some extensions such as kernel Principal Component Analysis, Independent Component Analysis and Manifold Learning.
Multiple Prioritized Outcomes
Authors: Buyse Marc 
Published: February 2019

Abstract
Generalized pairwise comparisons (GPCs) can be used to compare two groups of observations when several outcomes are simultaneously of interest and/or when thresholds of clinical relevance are specified for some of these outcomes. One approach to the analysis is to prioritize the outcomes from the most important to the least important. The order of priorities can be patient dependent, and as such this approach paves the way to personalized medicine. GPCs lead to a general measure of the difference between the groups, the “net benefit,” which is the probability that a patient randomly selected from the treatment group has a better outcome than a patient randomly selected from the control group, minus the probability of the opposite situation.
TheWeibull Regression Model
Authors: Cordeiro Gauss M. , Ortega Edwin M. M. 
Published: February 2019

AbstractWe provide a comprehensive review about the Weibull regression model. The topics considered include the Weibull regression model, log‐Weibull regression model, and diagnostics and residual analysis. Some recent extensions of the Weibull regression model with censored data are addressed telegraphically. It is hoped that this article could serve as an important reference and encourage developments for further generalizations of the Weibull regression model.
Bayesian Methods in Sport Statistics
Authors: Santos‐Fernandez Edgar , Mengersen Kerrie L. , Wu Paul 
Published: February 2019

AbstractBayesian techniques are being quickly adopted in sports settings. The volume and variety of data produced in sports activities over the past years and the availability of software packages for Bayesian computation have contributed positively to this growth. This article provides a brief review of the latest advances in Bayesian statistics in sports, covering methods and applications. In the literature surveyed, we found a similar number of publications between 2013 and 2017 and those published in the three previous decades, which is an indication of the rapid adoption rate of Bayesian methods in sports.
Good,IrvingJohn
Authors: Xu Yi , Banks David 
Published: February 2019

AbstractIrving John (Jack) Good was born Isidore Jacob Gudak in London on 9 December 1916, and died in Roanoke, Virginia, on 5 April 2009. He was a pioneer in Bayesian statistics, and contributed significantly to mathematics, computer science, and philosophy. During World War II, he was one of the leading cryptanalysts at Bletchley Park. After the war, he taught at the University of Manchester before joining the Government Communications Headquarters. In 1962, he moved to the United States, and in 1967 became a University Distinguished Professor of Statistics at Virginia Tech in Blacksburg, VA. Much of this article is based on an extended interview with I. J. Good that was conducted by David Banks in 1995.
Godambe,VidyadharPrabhakar
Authors: Thompson Mary E. 
Published: February 2019

AbstractVidyadhar P. Godambe is recognized as a pioneer in the foundations of inference in survey sampling. He is also known for formulating and developing a theory of optimality for estimating functions and estimating equations, with applications to inference for stochastic processes and other data structures. His research contributions, and the fervor with which he pursued the answers to fundamental questions, attracted many other researchers and students to work in the foundations of inference.
Ubiquitin/Proteasome System in Plant Pathogen Responses
Authors: Sorel Maud , Mooney Brian , de Marchi Rémi , Graciet Emmanuelle 
Published: February 2019

Abstract
In eukaryotes, the ubiquitin/proteasome system plays crucial roles in the regulation of protein stability. These functions are largely mediated through the covalent attachment of ubiquitin to substrate proteins and their targeting to the 26S proteasome, a large multi‐subunit protease. In the last three decades, the ubiquitin system has been shown to regulate essentially all processes in eukaryotes. In plants, it appears to play particularly important roles, perhaps as a result of the plants' sessile lifestyle and their need to adapt to rapidly changing environmental conditions. In particular, the ubiquitin system is key to the regulation of plant responses to pathogens, not only during interaction with a pathogen but also in the absence of infection to prevent the constitutive activation of defence responses that would have detrimental effects. In this article, we discuss the roles of the ubiquitin system in the regulation of different cellular pathways involved in plant defence responses, including the regulation of transmembrane and intracellular receptors, and the control of the signalling pathways that are activated downstream of pathogen detection. We also review how pathogens hijack the ubiquitin system to increase their virulence. Finally, we briefly discuss the emerging roles of autophagy in the regulation of plant/pathogen interactions.
Mechanically Activated Microcapsules for “On‐Demand” Drug Delivery in Dynamically Loaded Musculoskeletal Tissues
Authors: Mohanraj Bhavana , Duan Gang , Peredo Ana , Kim Miju , Tu Fuquan , Lee Daeyeon , Dodge George R. , Mauck Robert L. 
Published: February 2019

AbstractDelivery of biofactors in a precise and controlled fashion remains a clinical challenge. Stimuli‐responsive delivery systems can facilitate “on‐demand” release of therapeutics in response to a variety of physiologic triggering mechanisms (e.g., pH, temperature). However, few systems to date have taken advantage of mechanical inputs from the microenvironment to initiate drug release. Here, mechanically activated microcapsules (MAMCs) are designed to deliver therapeutics in response to the mechanically loaded environment of regenerating musculoskeletal tissues, with the ultimate goal of furthering tissue repair. To establish a suite of microcapsules with different thresholds for mechanoactivation, MAMC physical dimensions and composition are first manipulated, and their mechano‐response under both direct 2D compression and in 3D matrices mimicking the extracellular matrix properties and dynamic loading environment of regenerating tissue, is evaluated. To demonstrate the feasibility of this delivery system, an engineered cartilage model is used to test the efficacy of mechanically instigated release of transforming growth factor‐β3 on the chondrogenesis of mesenchymal stem cells. These data establish a novel platform by which to tune the release of therapeutics and/or regenerative factors based on the physiologic mechanical loading environment and will find widespread application in the repair and regeneration of musculoskeletal tissues.
Tumor‐Specific Aptamer‐Conjugated Polymeric Photosensitizer for Effective Endo‐Laparoscopic Photodynamic Therapy
Authors: Kim Jiyoung , Park Wooram , Kim Dahye , Lee Eun Seong , Lee Don Haeng , Jeong Seok , Park Jae Myung , Na Kun 
Published: February 2019

AbstractRecent advances in medical technology and endo‐laparoscopic devices have enabled the treatment of gastrointestinal (GI) cancers to be minimally invasive through endo‐laparoscopic photodynamic therapy (PDT). To achieve an efficient regional or endo‐laparoscopic PDT, it is necessary to develop a highly target specific photosensitizer (PS) that can be easily treated to the lesion site with endo‐laparoscopic device. Here, an ideal polymeric PS is demonstrated for effective endo‐laparoscopic PDT. In the synthetic process, conventional PS (i.e., Chlorin e6, Ce6) is conjugated with an Aptamer (i.e., AS1411) targeting nucleolin (also called C23) overexpressed on the cancer cell membrane using a water‐soluble polymeric linker (i.e., polyethylene glycol, PEG). The synthesized Aptamer‐PEG‐Ce6 could target nucleolin‐overexpressing tumor cells efficiently and visualize the tumor tissues through optical and fluorescent imaging both in vitro and ex vivo, and effectively kills cancer cells under laser irradiation. Tumor staining with Aptamer‐PEG‐Ce6 is easily accomplished through endoscopic equipment within a few minutes. Furthermore, after laser irradiation, Aptamer‐PEG‐Ce6 is found to penetrate deeply into the tumor tissue and induce apoptosis of tumor cells. Taken together, the tumor‐specific Aptamer‐conjugated polymeric PS developed in this study has great potential as an ideal photomedicine for effective tumor treatment using endo‐laparoscopic PDT.
Solution‐Processed Thermally Activated Delayed Fluorescent OLED with High EQE as 31% Using High Triplet Energy Crosslinkable Hole Transport Materials
Authors: Tsai Kuen‐Wei , Hung Miao‐Ken , Mao Yi‐Hen , Chen Show‐An 
Published: February 2019

AbstractSolution‐processed organic light‐emitting diodes (OLEDs) with thermally activated delayed fluorescent (TADF) material as emitter have attracted much attention because of their low cost and high performance. However, exciton quench at the interface between the hole injection layer, poly(3,4‐ethylenedioxythiophene):poly(styrene sulfonate) (PEDOT:PSS), and emitting layer (EML) in devices can lead to low device performance. Here, a novel high triplet energy (2.89 eV) and crosslinkable hole‐transporting material grafted with oxetane groups, N,N‐bis(4‐(6‐((3‐ethyloxetan‐3‐yl)methoxy)hexyloxy)phenyl)‐3,5‐di(9H‐carbazol‐9‐yl)benzenamine (Oxe‐DCDPA)), as crosslinked hole transport layer (HTL) into the interface of PEDOT:PSS layer and EML is proposed for prevention of exciton quenching, and among the reported devices with single HTL in solution‐processed TADF‐OLED, the highest external quantum efficiency (EQE)/luminous efficiency (ηL) of 26.1%/94.8 cd A−1 and 24.0%/74.0 cd A−1 are achieved for green emission (DACT‐II as emitter) and bluish‐green emission (DMAC‐TRZ as emitter), respectively. Further improvement, using double HTLs, composed of N,N′‐bis(4‐(6‐((3‐ethyloxetan‐3‐yl)methoxy))‐hexylphenyl)‐N,N′‐diphenyl‐4,4′‐diamine with high hole mobility and Oxe‐DCDPA with high triplet energy, leads to the highest EQE/ηL of 30.8%/111.9 cd A−1 and 27.2%/83.8 cd A−1 for green emission and bluish‐green emission, respectively. These two devices show the high maximum brightness of 81 100 and 70 000 cd m−2, respectively.
Bioinspired Adhesive Architectures: From Skin Patch to Integrated Bioelectronics
Authors: Baik Sangyul , Lee Heon Joon , Kim Da Wan , Kim Ji Won , Lee Youngkwan , Pang Changhyun 
Published: February 2019

AbstractThe attachment phenomena of various hierarchical architectures found in nature have extensively drawn attention for developing highly biocompatible adhesive on skin or wet inner organs without any chemical glue. Structural adhesive systems have become important to address the issues of human–machine interactions by smart outer/inner organ‐attachable devices for diagnosis and therapy. Here, advances in designs of biologically inspired adhesive architectures are reviewed in terms of distinct structural properties, attachment mechanisms to biosurfaces by physical interactions, and noteworthy fabrication methods. Recent demonstrations of bioinspired adhesive architectures as adhesive layers for medical applications from skin patches to multifunctional bioelectronics are presented. To conclude, current challenges and prospects on potential applications are also briefly discussed.
Nanoengineered Immune Niches for Reprogramming the Immunosuppressive Tumor Microenvironment and Enhancing Cancer Immunotherapy
Authors: Phuengkham Hathaichanok , Ren Long , Shin Il Woo , Lim Yong Taik 
Published: February 2019

AbstractCancer immunotherapies that harness the body's immune system to combat tumors have received extensive attention and become mainstream strategies for treating cancer. Despite promising results, some problems remain, such as the limited patient response rate and the emergence of severe immune‐related adverse effects. For most patients, the therapeutic efficacy of cancer immunotherapy is mainly limited by the immunosuppressive tumor microenvironment (TME). To overcome such obstacles in the TME, the immunomodulation of immunosuppressive factors and therapeutic immune cells (e.g., T cells and antigen‐presenting cells) should be carefully designed and evaluated. Nanoengineered synthetic immune niches have emerged as highly customizable platforms with a potent capability for reprogramming the immunosuppressive TME. Here, recent developments in nano‐biomaterials that are rationally designed to modulate the immunosuppressive TME in a spatiotemporal manner for enhanced cancer immunotherapy which are rationally designed to modulate the immunosuppressive TME in a spatiotemporal manner for enhanced cancer immunotherapy are highlighted.
Plasmon‐Enhanced Photoelectrochemical Water Splitting for Efficient Renewable Energy Storage
Authors: Mascaretti Luca , Dutta Aveek , Kment Štěpán , Shalaev Vladimir M. , Boltasseva Alexandra , Zbořil Radek , Naldoni Alberto 
Published: February 2019

AbstractPhotoelectrochemical (PEC) water splitting is a promising approach for producing hydrogen without greenhouse gas emissions. Despite decades of unceasing efforts, the efficiency of PEC devices based on earth‐abundant semiconductors is still limited by their low light absorption, low charge mobility, high charge‐carrier recombination, and reduced diffusion length. Plasmonics has recently emerged as an effective approach for overcoming these limitations, although a full understanding of the involved physical mechanisms remains elusive. Here, the reported plasmonic effects are outlined, such as resonant energy transfer, scattering, hot electron injection, guided modes, and photonic effects, as well as the less investigated catalytic and thermal effects used in PEC water splitting. In each section, the fundamentals are reviewed and the most representative examples are discussed, illustrating possible future developments for achieving improved efficiency of plasmonic photoelectrodes.
Lead Halide Post‐Perovskite‐Type Chains for High‐Efficiency White‐Light Emission
Authors: Gautier Romain , Massuyeau Florian , Galnon Gabin , Paris Michael 
Published: February 2019

AbstractHybrid metal halides containing perovskite layers have recently shown great potential for applications in solar cells and light‐emitting diodes. Such compounds exhibit quantum confinement effects leading to tunable optical and electronic properties. Thus, broadband white‐light emission has been observed from diverse metal halides and, owing to high color rendering index, high thermal stability, and low‐temperature solution processability, these materials have attracted interest for application in solid‐state lighting. However, the reported quantum yields for white photoluminescence (PLQY) remain low (i.e., in the range 0.5–9%) and no approach has shown to successfully increase the intensity of this emission. Here, it is demonstrated that the quantum efficiencies of hybrid metal halides can be greatly enhanced if they contain a polymorph of the [PbX4]2− perovskite‐type layers: the [PbX4]2− post‐perovskite‐type chains showing a PLQY of 45%. Different piperazines lead to a hybrid lead halide with either perovskite layers or post‐perovskite chains influencing strongly the presence of self‐trapped states for excitons. It is anticipated that this family of hybrid lead halide materials could enhance all the properties requiring the stabilization of trapped excitons.