bluuebunny/crossref_metadata_2025_split huggingface dataset:
Management of depression in patients with schizophrenia spectrum disorders: a critical review of international guidelines
Authors: Dondé C. , Vignaud P. , Poulet E. , Brunelin J. , Haesebaert F. 
Published: July 2018

ObjectivesDepression is a frequent but potentially treatable clinical dimension in patients with schizophrenia spectrum disorders (PWS). However, there is a lack of consensual recommendations regarding the optimal strategy to manage depression in PWS. In this study, we aimed to compare the various proposed strategies to define a core set of valid care recommendations for depression management in PWS.MethodsAfter a systematic search of the literature, the methodological quality of 10 international guidelines from four continents was compared using a validated guideline appraisal instrument (AGREE II). Key recommendations for the management of depression in PWS were subsequently reviewed and discussed.ResultsThe methodological quality of the guidelines was heterogeneous. Although all guidelines proposed pharmacotherapy, psychosocial interventions were a minor concern. Waiting for antipsychotic effects mostly was recommended during the acute phase of schizophrenia. During the postpsychotic phase of the illness, a switch to a second‐generation antipsychotic and/or the adjunction of an antidepressant were the primary recommendations. Cognitive behavioural therapy and other medications were considered with strong variations.ConclusionsFurther studies are needed to strengthen the level of evidence for antidepressive approaches in PWS. The inclusion of PWS as stakeholders is also considered to be a major issue for future guideline development.
Women's role in the rise in drinking in Australia 1950–80: an age–period–cohort analysis of data from the Melbourne Collaborative Cohort Study
Authors: Stanesby Oliver , Jayasekara Harindra , Callinan Sarah , Room Robin , English Dallas , Giles Graham G. , MacInnis Robert J. , Milne Roger L. , Livingston Michael 
Published: July 2018

AbstractBackground and AimsIn Australia, as in many countries, alcohol consumption increased dramatically during the second half of the 20th century, with increased availability of alcohol, relaxation of attitudes towards drinking and shifting roles and opportunities for women as facilitating factors. We sought to investigate drinking trends by gender and birth cohort in Australia during this period.DesignRetrospective cohort study.Setting, Participants and MeasurementsUsing the usual frequency and quantity of beverage‐specific alcohol intake for 10‐year periods from age 20, reported retrospectively from 40 789 participants aged 40–69 years (born 1920–49) at recruitment to the Melbourne Collaborative Cohort Study in 1990–94, we compared trends in alcohol consumption by sex in Australia between 1950 and 1990. Participants’ average daily consumption for age decades were transformed to estimated intakes for 1950, 1960, 1970, 1980 and 1990.FindingsAlcohol consumption was higher for men than women during each decade. Alcohol consumption increased for both sexes in the 1950s, 1960s and 1970s, and fell after 1980. The rise before 1980 was roughly equal in absolute terms for both sexes, but much greater relative to 1950 for women. Women born during 1930–39 and 1940–49 drank more alcohol during early–middle adulthood (ages 20–40) than women born during 1920–29. In the 1980s, the fall was greater in absolute terms for men, but roughly equal relative to 1950 for both sexes. In both sexes, the decline in drinking in the 1980s for birth‐decade cohorts was roughly in parallel.ConclusionsSpecific birth cohorts were influential in the rise in alcohol consumption by Australian women born in 1920–49 after World War II. Much of the convergence with men's drinking after 1980 reflects large reductions in drinking among men.
Are Odonata nymph adversely affected by impaired water quality in urban streams
Authors: Tippler Carl , Wright Ian A. , Davies Peter J. , Evans Claire R. 
Published: July 2018

AbstractGlobally 10% of all dragonfly species are threatened by extinction that can be primarily attributed to a loss of natural habitat. Urban expansion and the associated urban stream syndrome has established that the extent and intensity of urban development is directly linked to a range of adverse physical, chemical and ecological changes. Urban waterways typically experience degraded water quality and are occupied by impaired communities of aquatic invertebrates which are mostly dominated by rapid colonizing insects. Odonata are a diverse insect group and their tolerance or sensitivity to urban waterway degradation is unclear. This research examined the response of aquatic macroinvertebrate communities and specifically the Odonata nymph community to impaired water quality and degraded riparian vegetation condition in streams of the Georges River catchment, Sydney, across an urban development gradient. Unlike the overall macroinvertebrate community, Odonata nymph species assemblages were not strongly linked to the urban development gradient nor the degree of degradation in water quality. This result diverges from many aquatic macroinvertebrate studies that have reported a correlation between the response of Odonata taxa to degraded water quality. Our findings conclude that Odonata nymph community alone are not a suitable indictor of urban stream degradation as measured by water quality or catchment imperviousness and that the conservation of urban dragonflies should place a greater focus on the conservation and creation of suitable habitats.
Second primary malignancy after multiple myeloma‐population trends and cause‐specific mortality
Authors: Costa Luciano J. , Godby Kelly N. , Chhabra Saurabh , Cornell Robert Frank , Hari Parameswaran , Bhatia Smita 
Published: July 2018

SummaryThe management of multiple myeloma (MM) has evolved with the increased use of autologous haematopoietic cell transplantation (AHCT) and the introduction of new agents. AHCT and lenalidomide maintenance have been associated with increased risk of second primary malignancy (SPM). We iseutilised the Surveillance, Epidemiology and End Results 13 registries to analyse 9 833 patients diagnosed at age <65 years for three eras: 1995–99 (pre‐thalidomide, limited use of AHCT), 2000–04 (post‐thalidomide, pre‐lenalidomide and bortezomib, increased isautilisation of AHCT) and 2005–09 (post‐lenalidomide and bortezomib, higher isautilisation of AHCT). Changes in risk of SPM were assessed by utilising standardised incidence ratio (SIR) and cause‐specific risk of death. Cumulative incidence of SPM at 90 months was 4·7%, 6·0% and 6·3% respectively, P = 0·0008. SIR for haematological malignancies in years 1–5 increased, from 1·28 (95% confidence interval [CI] 0·47–2·78) in 1995–99 to 2·17 (95% CI: 1·27–3·48) in 2005–09, due to increased risk of acute leukaemias and lymphomas. A similar trend was observed in years 6–10. Overall mortality in patients with MM declined sharply over time due to declines in MM‐associated and cardiovascular mortality with no increase in risk of death from SPM. The evolution of MM therapy is linked to population‐level increase in risk with no discernible effect in death from SPM.
An unbalanced monocyte macrophage polarization in the bone marrow microenvironment of patients with poor graft function after allogeneic haematopoietic stem cell transplantation
Authors: Zhao Hong‐Yan , Lyu Zhong‐Shi , Duan Cai‐Wen , Song Yang , Han Ting‐Ting , Mo Xiao‐Dong , Wang Yu , Xu Lan‐Ping , Zhang Xiao‐Hui , Huang Xiao‐Jun , Kong Yuan 
Published: July 2018

SummaryPoor graft function (PGF) is a severe complication of allogeneic haematopoietic stem cell transplantation (allo‐HSCT). Murine studies have demonstrated that effective haematopoiesis depends on the specific bone marrow (BM) microenvironment. Increasing evidence shows that BM macrophages (MФs), which constitute an important component of BM immune microenvironment, are indispensable for the regulation of haematopoietic stem cells (HSCs) in the BM. However, little is known about the number and function of BM MФs or whether they directly interact with HSCs in PGF patients. In the current prospective case‐control study, PGF patients showed a significant increase in classically activated inflammatory MФs (M1; 2·18 ± 0·11% vs. 0·82 ± 0·06%, P < 0·0001), a striking reduction in alternatively activated anti‐inflammatory MФs (M2; 3·02 ± 0·31% vs. 21·89 ± 0·90%, P < 0·0001), resulting in a markedly increased M1/M2 ratio (0·82 ± 0·06 vs. 0·06 ± 0·002; P < 0·0001) in the BM compared with good graft function patients. Meanwhile, standard monocyte subsets were altered in PGF patients. Dysfunctional BM MФs, which were characterized by reduced proliferation, migration and phagocytosis, were evident in PGF patients. Furthermore, BM MФs from PGF patients with high tumour necrosis factor‐α and interleukin 12 levels and low transforming growth factor‐β levels, led to impaired BM CD34+ cell function. In summary, our data indicate that an unbalanced BM M1/M2 ratio and dysfunctional MФs may contribute to the occurrence of PGF following allo‐HSCT.
Evidence of linkage to chromosome 5p13.2‐q11.1 in a large inbred family with genetic generalized epilepsy
Authors: Kinay Demet , Oliver Karen L. , Tüzün Erdem , Damiano John A. , Ulusoy Canan , Andermann Eva , Hildebrand Michael S. , Bahlo Melanie , Berkovic Samuel F. 
Published: July 2018

SummaryThe clinical genetics of genetic generalized epilepsy suggests complex inheritance; large pedigrees, with multiple affected individuals, are rare exceptions. We studied a large consanguineous family from Turkey where extensive electroclinical phenotyping revealed a familial phenotype most closely resembling juvenile myoclonic epilepsy. For a subject to be considered affected (n = 14), a diagnostic electroencephalogram was required. Seizure onset ranged between 6 and 19 years (mean = 12 years). Thirteen of 14 experienced myoclonic jerks; in 11, this was associated with eyelid blinking, and in 10 it was interspersed with absences. Generalized tonic–clonic seizures were seen in 11. One individual had generalized tonic–clonic seizures alone. Electroencephalograms demonstrated generalized polyspike and wave discharges that were not associated with photoparoxysmal response. Intellect was normal. Nineteen family members were subsequently chosen for nonparametric multipoint linkage analyses, which identified a 39.5 Mb region on chromosome 5 (P < 0.0001). Iterative analysis, including discovery of a subtly affected individual, narrowed the critical region to 15.4 Mb and possibly to 5.5 Mb. Homozygous versus heterozygous state of the refined 5p13.2‐q11.1 haplotype was not associated with phenotypic severity or onset age, suggesting that one versus two pathogenic variants may result in similar phenotypes. Whole exome sequencing (n = 3) failed to detect any rare, protein‐coding variants within the highly significant linkage region that includes HCN1 as a promising candidate.
Time‐selective integrated scheduling algorithm with backtracking adaptation strategy
Authors: Zhang Xiaohuan , Xie Zhiqiang , Xin Yu , Yang Jing 
Published: July 2018

AbstractCurrently, integrated scheduling algorithms schedule processes using fixed rules, making it difficult to balance serial and parallel processes in product craftsmanship trees while conducting complicated single product scheduling. To solve this problem, we propose a time‐selective integrated scheduling algorithm with a backtracking adaptation (TISAWBA) strategy. The proposed process sequence sorting strategy aims to determine process scheduling sequences based on the overall structure of the machining craftsmanship tree. The proposed time‐selective scheduling strategy aims to select the process portfolio with the minimum total elapsed time for machining from a process portfolio set based on craftsmanship tree structure. The proposed backtracking adaptation strategy conducts backtracking adaptation to find process portfolios having a total elapsed machining time greater than the “scheduling reference time.” Finally, illustrative use cases verify that TISAWBA guarantees parallel processing for parallel processes and elevates the proximity of serial processes, generating optimized integrated scheduling results.
Research on the mechanism of knowledge and intelligence sharing in enterprises under big data: From the perspective of status‐striving motivation and opinion dynamics
Authors: Zhu Guiyan , Ma Xiaomeng , Liu Benfa 
Published: July 2018

AbstractKnowledge sharing is the process of individual knowledge interaction in the team. To understand the social psychological mechanism in the process of knowledge sharing, this article combines status‐striving motivation with opinion dynamics to study the decision mechanism and evolution law of employee knowledge sharing behaviour. A multiagent simulation method is used to design the decision‐making model of employee knowledge sharing behaviour. The influence of the network structure, number of people, and the proportion of employees with different statuses on knowledge sharing performance is considered. The simulation software is used to convert the theoretical model into a parametric experiment, and the sensitivity analysis is also employed. The results show that the knowledge of individuals with high status will increase initially, but the upward trend will eventually slow until reaching a steady state. The steady‐state status of employees is positively correlated with their initial knowledge volume.
Long‐term limnological changes in the Ecuadorian páramo: Comparing the ecological responses to climate warming of shallow waterbodies versus deep lakes
Authors: Giles Mark P. , Michelutti Neal , Grooms Christopher , Smol John P. 
Published: July 2018

AbstractPáramos are high‐altitude ecosystems of grasslands and shrubs that sustain high levels of biodiversity and contain numerous lakes, ponds and wetlands that are a crucial source of water for millions. In the Andes, limnological data are rare from páramos and particularly so from shallow waterbodies that are prominent features of the landscape.Here, we analyse fossil diatom assemblages using dated sediment cores from three shallow lakes in the páramo of southern Ecuador and document their response to recent climate changes. The two shallowest sites were <0.5 m deep and contained nearly identical diatom assemblages, dominated byAchnanthidium minutissimumand other benthic taxa. The deepest study site, at 4 m depth, differed notably from its shallower counterparts in that the dominant taxa were tychoplanktonicAulacoseiraspecies. All three study sites showed only minor assemblage shifts over the past ˜200 years. This contrasts sharply with paleolimnological data from nearby deep lakes (Zmax > 17 m) that recorded abrupt changes in diatom phytoplankton coincident with the onset of higher temperatures, reduced wind speeds and the onset of thermal stratification in recent decades.In temperate and high‐latitude regions, an overriding factor influencing freshwater ecosystems is the duration and extent of ice cover, which itself is closely linked to climate variables. In contrast, there is no winter ice cover and the growing season is continuous year round in our equatorial Andean sites. Instead, rising temperatures are affecting deep lakes primarily by altering the physical structure of the water column resulting in greater periods of thermal stratification, which in turn drives changes in biota and other lake processes. However, this mechanism of change only affects deep lakes because shallow waterbodies are easily mixed by wind.Our data demonstrate the differential response of large, deep lakes in the páramo compared to the relative complacency of changes in shallow waterbodies, which is in marked contrast to similar sites affected by seasonal ice cover.
Acne prevalence in 9 to 14‐year‐old old patients attending pediatric ambulatory clinics in Italy
Authors: Napolitano Maddalena , Ruggiero Giuseppe , Monfrecola Giuseppe , Megna Matteo 
Published: July 2018

AbstractBackgroundAcne vulgaris is a chronic inflammatory skin disease of the pilosebaceous follicles that affects patients of all ages with a younger onset being more common than in the past.ObjectivesTo investigate on the prevalence, clinical features and treatments of acne in 9 to 14‐year‐old patients.MethodsA prospective observational study was conducted between April 2016 and May 2016. The study population consisted of patients attending 32 different pediatric ambulatory clinics located in Italy (North: 56.25%, Center: 18.75%, South: 25%). For each patient, a specific questionnaire was registered: i) demographic data; ii) past personal history of acne; iii) auxologic parameters. Further data were gathered for patients suffering from acne at study enrollment: i) body areas involved by the disease; ii) acne severity evaluated through a 0‐5 scale (Global Evaluation Acne scale); iii) acne treatments.ResultsA total of 683 children (49.2% male; mean age 11.05 ± 1.4 years) were enrolled. Acne was present in 234/683 (34.3%) of the patients, and its prevalence increased with age being higher after 13 years of age (85/234; 36.3%) and lowest at 9 years of age (14/234; 6%). The majority of the patients suffering from acne showed a mild or almost clear disease state severity (GEA scale 1 or 2) (207/234, 88.5%), whereas severe or very severe forms (GEA scale 4 or 5) represented only 4/234, 1.7% of the cases.ConclusionsAcne is not a rare disease in pre‐adolescent age. Adequate and prompt treatment is also needed in this class of patient to minimize disease burden and potential future disease worsening.
Cosmopolitanism, Occupancy and Political Self‐Determination
Authors: Wellman Christopher Heath 
Published: July 2018

AbstractThe brand of cosmopolitanism that Cécile Fabre develops in her excellent book, Cosmopolitan Peace, leaves room for qualifying groups to exercise political self‐determination. Important questions thus emerge regarding who is entitled to have a say in the group's self‐determination, questions that take on a heightened practical urgency in the wake of wars that cause massive migration. In this article, I call into question Fabre's contention that the descendants of unjust occupants necessarily acquire occupancy rights which entitle them to a say in the political self‐determination over the territory on which they currently reside.
Abnormal trading behavior of specific types of shareholders before US firm bankruptcy and its implications for firm bankruptcy prediction
Authors: Cheng Christine , Jones Stewart , Moser William J. 
Published: July 2018

AbstractThis paper examines the trading behavior of US corporate insiders and certain groups of institutional investors (short‐term, transient, top‐performing, and those with fiduciary responsibility) in the eight quarters leading up to a US firm bankruptcy filing. Using a matched sample based on year, industry, and a probability of future bankruptcy model, we find that US corporate insiders display abnormal reduced net trading activity in the quarters before bankruptcy, with corporate insiders ‘going quiet’ immediately preceding a US bankruptcy. In contrast, we find that our identified types of institutional shareholders display abnormal selling activity several quarters before a US bankruptcy. We then use this information to enhance the bankruptcy‐predictive capabilities of recent machine‐learning techniques such as gradient boosting, as well as the probability of future bankruptcy model. We find that the variables measuring the absolute value of net purchases by US corporate insiders in the two quarters prior to bankruptcy, along with the changes in ownership by specific types of institutional shareholders, improve the out‐of‐sample predictive capabilities of our two different bankruptcy prediction models. Overall, we find that specific types of shareholder display abnormal trading in the quarters preceding US firm bankruptcy, and such information improves the out‐of‐sample accuracy of firm bankruptcy prediction models.
Reducing uncertainty in estimating associations of oral exposures with Helicobacter pylori serology in the general population
Authors: Schwahn Christian , Samietz Stefanie , Mundt Torsten , Völzke Henry , Kocher Thomas , Mayerle Julia , Holtfreter Birte , Lerch Markus M. , Biffar Reiner , Schulz Christian 
Published: July 2018

AbstractAimEvidence for reducing Helicobacter (H.) pylori by periodontal therapy comes from small studies in China, limiting generalizability. To estimate the association between periodontal disease and anti‐H. pylori IgG titer levels in a European country, we used population‐based data from the Study of Health in Pomerania.Materials and MethodsFor pocket depth as the primary exposure, we restricted the age range to participants younger than 60 years (n = 2,481) to avoid selection bias due to edentulism in this cross‐sectional study. For the full age range up to 81 years, we chose the number of missing teeth (n = 3,705).ResultsThe association between pocket depth and the outcome was weak. Given the ceiling effect for the number of missing teeth (ordinal logistic regression; odds ratio of the interquartile range effect = 1.6; 95% CI: 1.3–1.9; p‐value for linearity = 0.005), we checked whether wearing removable dental prosthesis was associated with higher anti‐H. pylori IgG titer levels (odds ratio = 1.3; 95% CI: 1.1–1.5).ConclusionsTooth loss and wearing removable dental prosthesis were weakly to moderately associated with higher anti‐H. pylori IgG titer levels in the general population of a European country.
Rab‐H1b is essential for trafficking of cellulose synthase and for hypocotyl growth in Arabidopsis thaliana
Authors: He Ming , Lan Miao , Zhang Baocai , Zhou Yihua , Wang Youqun , Zhu Lei , Yuan Ming , Fu Ying 
Published: July 2018

AbstractCell‐wall deposition of cellulose microfibrils is essential for plant growth and development. In plant cells, cellulose synthesis is accomplished by cellulose synthase complexes located in the plasma membrane. Trafficking of the complex between endomembrane compartments and the plasma membrane is vital for cellulose biosynthesis; however, the mechanism for this process is not well understood. We here report that, in Arabidopsis thaliana, Rab‐H1b, a Golgi‐localized small GTPase, participates in the trafficking of CELLULOSE SYNTHASE 6 (CESA6) to the plasma membrane. Loss of Rab‐H1b function resulted in altered distribution and motility of CESA6 in the plasma membrane and reduced cellulose content. Seedlings with this defect exhibited short, fragile etiolated hypocotyls. Exocytosis of CESA6 was impaired in rab‐h1b cells, and endocytosis in mutant cells was significantly reduced as well. We further observed accumulation of vesicles around an abnormal Golgi apparatus having an increased number of cisternae in rab‐h1b cells, suggesting a defect in cisternal homeostasis caused by Rab‐H1b loss function. Our findings link Rab GTPases to cellulose biosynthesis, during hypocotyl growth, and suggest Rab‐H1b is crucial for modulating the trafficking of cellulose synthase complexes between endomembrane compartments and the plasma membrane and for maintaining Golgi organization and morphology.