bluuebunny/crossref_metadata_2025_split huggingface dataset:
Morphology and surface properties of high strength siloxane poly(urethane‐urea)s developed for heart valve application
Authors: Dandeniyage Loshini S. , Adhikari Raju , Bown Mark , Shanks Robert , Adhikari Benu , Easton Christopher D. , Gengenbach Thomas R. , Cookson David , Gunatillake Pathiraja A. 
Published: March 2018

ABSTRACTA series of siloxane poly(urethane‐urea) (SiPUU) were developed by incorporating a macrodiol linked with a diisocyanate to enhance mixing of hard and soft segments (SS). The effect of this modification on morphology, surface properties, surface elemental composition, and creep resistance was investigated. The linked macrodiol was prepared by reacting α,ω‐bis(6‐hydroxyethoxypropyl) poly(dimethylsiloxane)(PDMS) or poly(hexamethylene oxide) (PHMO) with either 4,4′‐methylenediphenyl diisocyanate (MDI), hexamethylene diisocyanate (HDI), or isophorone diisocyanate (IPDI). SiPUU with PHMO‐MDI‐PHMO and PHMO‐IPDI‐PHMO linked macrodiols showed enhanced creep resistance and recovery when compared with a commercial biostable polyurethane, Elast‐Eon™ 2A. Small and wide‐angle X‐ray scattering data were consistent with significant increase of hydrogen bonding between hard and SS with linked‐macrodiols, which improved SiPUU's tensile stress and tear strengths. These SiPUU were hydrophobic with contact angle higher than 101° and they had low water uptake (0.7%·w/w of dry mass). They also had much higher siloxane concentration on the surface compared to that in the bulk. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 107B: 112–121, 2019.
The combined use of a continuous‐flow microchannel reactor and ionic liquid cosolvent for efficient biocatalysis of unpurified recombinant enzyme
Authors: Wang Fangqin , He Shu , Zhu Changtong , Rabausch Ulrich , Streit Wolfgang , Wang Jun 
Published: March 2018

AbstractBACKGROUNDMicrofluidic biocatalysis has advantages in terms of heat transfer and mass transfer. However, mass transfer in microscale conditions is often limited by excessive enzyme agglomeration, resulting in reduced reactor performance. In the present study, to establish an efficient and inexpensive microreaction system for obtaining high‐value fine chemicals, a novel combined use of continuous‐flow microchannel reactor and ionic liquid cosolvent for efficient production of isoquercitrin from rutin catalysed by unpurified recombinant enzyme RhaB1 was successfully carried out.RESULTSThe unpurified RhaB1 was expressed by BL21‐pET21a‐rhaB1 and the amino acid sequence was confirmed by Maldi‐TOF‐TOF, which was directly applied in microchannel reactors with an increased activity of 37.7% compared with the purified RhaB1, with [Toma][Tf2N] used as a cosolvent to avoid enzymatic agglomeration. A yield of 99.3 ± 4.3% was achieved in 10 min using crude RhaB1 in microchannel reactors under optimum conditions, and circular dichroism spectroscopy confirmed that [Toma][Tf2N] had a positive effect on RhaB1 activity. Compared with a batch reactor, the reaction time was reduced by 98.3%, the Km was decreased to 1/3 and productivity was improved 61.4 times.CONCLUSIONResults indicated that the developed cosolvent system in the microfluidic reactor could improve the solubility and liquidity of recombinant RhaB1. The protocol is promising for industrial applications due to higher productivity and lower costs. © 2018 Society of Chemical Industry
Mathematical modeling, steady state simulation, parametric analysis and optimization of SO2 capture in a countercurrent moving bed (CaO and C) reactor
Authors: Stefas Ioannis I , Manavi Stella I , Paloukis Fotis E , Spartinos Dimitrios Nikolaos 
Published: March 2018

AbstractThe use of absorbents based on calcium for the reduction of SO2 emissions from power plants has been studied for the last 30 years. The present work is part of a research project aimed at the development of a moving bed limestone filter. It is placed after burning in order to capture the SO2 from the flue gases of pulverized lignite combustors. A heterogeneous mathematical model was developed for the steady‐state simulation of a gas–solid countercurrent moving bed reactor. The mathematical model was solved using the method of finite elements and gave results for the temperature and conversion profile along the reactor. Also, parametric analysis (for Tg,in, Ts,in, us, qo, , , do, zo) was performed and useful conclusions concerning the behavior of a moving bed reactor in different conditions were drawn. Finally, optimization of conditions was performed to give an SO2 conversion higher than 0.95. The results are of important technological interest as a dry process in applications of SO2 capture. © 2018 Society of Chemical Industry
Highly efficient removal of toxic Pb2+ from wastewater by an alginate–chitosan hybrid adsorbent
Authors: Wang Zhuqing , Jin Pengxiang , Wang Min , Wu Genhua , Sun Jiayin , Zhang Yujie , Dong Chen , Wu Aiguo 
Published: March 2018

AbstractBACKGROUNDIn this study, a low‐cost and environment‐friendly alginate–chitosan hybrid adsorbent (depicted as Alg‐Chi) was developed for the removal of Pb2+ from water.RESULTSExperimental results showed that the Alg‐Chi exhibits high selectivity and affinity for Pb2+. The selectivity coefficients of the Alg‐Chi for Pb2+/Cr3+, Pb2+/Co2+ Pb2+/Cd2+, Pb2+/Zn2+, and Pb2+/Cu2+ are all >5. It can uptake 96.8% of Pb2+ from Pb2+‐containing solutions (1.5 mmol L−1), and the maximum adsorption capacity for Pb2+ reaches 468.5 mg g−1, which is higher than that of most reported adsorbents for Pb2+. Moreover, the Alg‐Chi can also be regenerated via simple acid elution and used repeatedly without loss in adsorption ability.CONCLUSIONSAnalysis of the adsorption mechanism indicated that the Alg‐Chi adsorbed Pb2+ mainly through ion exchange and chemical coordination. Green and low‐cost raw materials, simple preparation process, efficient removal efficiency and recyclable, these characteristics give the synthetic Alg‐Chi broad application prospects in the field of Pb2+‐containing wastewater treatment. © 2018 Society of Chemical Industry
Risk assessment, dissipation behavior and persistence of quinalphos in/on green pea by gas chromatography with electron capture detector
Authors: Dar Alamgir A. , Jan Ishrat , Wani Ashraf A. , Mubashir Sofi , Sofi Khurshid A. , Sofi Javid A. , Dar Irshad H. 
Published: March 2018

AbstractChemical investigation was carried out to examine the risk assessment, dissipation behavior, persistence, and half‐life period of quinalphos in/on green pea fruit by spraying quinalphos at fruiting stage followed by another application after 10‐day interval. The samples were extracted by using the quick, easy, cheap, effective, rugged, and safe method, and the residues of quinalphos were analyzed by gas chromatography with electron capture detector. Herein, we report a novel, accurate, and cost‐effective gas chromatography method for the determination of average deposits of quinalphos in/on green pea. The initial deposits and half‐life of quinalphos were found to be 1.20 mg/kg and 2.77 days, respectively, following the application of insecticide. Residues of quinalphos reached below detection limit of 0.05 mg/kg after 10 days at recommended dosage. For risk assessment studies, the tenth day will be safe for consumers for consumption of green pea. The developed method is simple, selective, and repeatable, and it can be extended for quinalphos‐based standardization of herbal formulations containing green pea and its use in pesticide industries.
Study on tribological properties of zinc perrhenate in oil‐based hybrid lubrication system over a broad temperature range
Authors: Wang Junhai , Zhang Lixiu , Li Ting , Zhang Ke 
Published: March 2018

AbstractThe zinc perrhenate used as oil additive was synthesised via aqua‐solution method and was dispersed into pentaerythritol ester with the surface‐active agents. The tribological properties of lubricants were examined by 4‐ball tester and ball‐on‐disc testing machine. Additional investigations were performed using XRD, XPS, SEM‐EDS, and DTA/TG to probe the possible lubricating mechanism. Four‐ball test results showed compared to base oil, the friction coefficient and wear scar diameter of oil with zinc perrhenate additive were reduced by 14.9% and 16.6%, suggesting that zinc perrhenate additive could improve the lubricating property of base oil under 4‐ball test condition. Frictional tests under a wide temperature range indicated that oil with zinc perrhenate additive exhibited friction‐reducing performance during elevated temperature process because of its intrinsic shear susceptible property and could form a protective layer with native oxides of the disc sample at the interface, thus significantly minimised friction.
Effect of Vitamin D Supplementation on Obesity‐Induced Insulin Resistance: A Double‐Blind, Randomized, Placebo‐Controlled Trial
Authors: Cefalo Chiara M.A. , Conte Caterina , Sorice Gian Pio , Moffa Simona , Sun Vinsin A. , Cinti Francesca , Salomone Enrica , Muscogiuri Giovanna , Brocchi Alex A.G. , Pontecorvi Alfredo , Mezza Teresa , Giaccari Andrea 
Published: March 2018

ObjectiveThe aim was to investigate whether vitamin D supplementation, combined with a hypocaloric diet, could have an independent effect on insulin sensitivity in subjects with both overweight and hypovitaminosis D. Changes from baseline in anthropometric parameters, body composition, glucose tolerance, and insulin secretion were considered as secondary outcomes.MethodsEighteen volunteers who were nondiabetic and vitamin D deficient and had BMI > 25 kg/m2 were randomized (1:1) in a double‐blind manner to a hypocaloric diet + either oral cholecalciferol at 25,000 IU/wk or placebo for 3 months. Hyperinsulinemic‐euglycemic clamp to measure insulin sensitivity was performed at baseline and after intervention.ResultsBody weight in both groups decreased significantly (−7.5% in the vitamin D group and −10% in the placebo group; P < 0.05 for both), with no between‐group differences. Serum 25‐hydroxyvitamin D levels in the vitamin D group increased considerably (from 36.7 ± 13.2 nmol/L to 74.8 ± 18.7 nmol/L; P < 0.001). Insulin sensitivity in the vitamin D group improved (from 4.6 ± 2.0 to 6.9 ± 3.3 mg·kg−1·min−1; P < 0.001), whereas no changes were observed in the placebo group (from 4.9 ± 1.1 to 5.1 ± 0.3 mg·kg−1·min−1; P = 0.84).ConclusionsCholecalciferol supplementation, combined with a weight loss program, significantly improves insulin sensitivity in healthy subjects with obesity and might represent a personalized approach for insulin‐resistant subjects with obesity.
Dietary Tryptophan Restriction Dose‐Dependently Modulates Energy Balance, Gut Hormones, and Microbiota in Obesity‐Prone Rats
Authors: Zapata Rizaldy C. , Singh Arashdeep , Ajdari Nadia M. , Chelikani Prasanth K. 
Published: March 2018

ObjectiveTo determine the effects of graded dietary restriction of tryptophan on food intake, energy expenditure, body composition, gut hormones, and select fecal bacterial populations in obesity‐prone rats.MethodsObesity‐prone rats were randomized to isocaloric diets with varying degrees of tryptophan restriction: control (100% requirements), 70% tryptophan (70TRP), 40% tryptophan (40TRP), or 10% tryptophan (10TRP) for 21 days. The sympathetic system was challenged with a subcutaneous injection of propranolol on days 15 to 17. Measurements included food intake, energy expenditure, body composition, metabolic hormones, and fecal concentrations of select bacteria.ResultsModerate tryptophan restriction (70TRP) induced thermogenesis without altering body composition, whereas severe degrees of restriction (40TRP, 10TRP) produced profound hypophagia and decreased energy expenditure and body weight. The thermogenic effects of moderate tryptophan restriction were sympathetically mediated. Severe tryptophan restriction decreased fasting circulating concentrations of glucose, insulin, C‐peptide, and leptin, but increased glucagon, pancreatic polypeptide, and glucagon‐like peptide‐1. Severe tryptophan restriction decreased fecal concentrations of Enterobacteriaceae, Lactobacillus, Bacteroides, and Clostridium coccoides while increasing Roseburia groups.ConclusionsOur findings demonstrate that dietary tryptophan restriction dose‐dependently modulates energy balance, with severe restriction causing hypophagia and weight loss and moderate restriction promoting sympathetically driven thermogenesis as well as concurrent changes in gut microbiota and hormones.
The Components of Age‐Dependent Effects of Dietary Methionine Restriction on Energy Balance in Rats
Authors: Wanders Desiree , Forney Laura A. , Stone Kirsten P. , Hasek Barbara E. , Johnson William D. , Gettys Thomas W. 
Published: March 2018

ObjectiveDietary methionine restriction (MR) improves biomarkers of metabolic health, in part through coordinated increases in energy intake and energy expenditure (EE). Some metabolic benefits of dietary MR are secondary to its effects on energy balance, so this study's purpose was to examine how age at initiation of MR influences its effects on energy balance and body composition.MethodsEnergy balance was examined in rats provided control or MR diets for 9 months after weaning or in rats between 6 and 12 months of age.ResultsRats provided the control diet for 9 months after weaning increased their body weight (BW) and fat mass by five‐ and eightfold, respectively, while BW and fat accumulation in the MR group were reduced to 50% of that of controls. In adult rats fed the respective diets between 6 and 12 months of age, dietary MR increased energy intake by ∼23%, but the 15% increase in EE was sufficient to prevent increases in BW or fat mass.ConclusionsDietary MR produces comparable increases in EE in young, growing animals and in mature animals, but young animals continue to deposit new tissue because of the proportionately larger effect of MR on energy intake relative to maintenance requirements.
N‐Substituted 1,2,3‐Triazolyl‐Appended Indole‐Chalcone Hybrids as Potential DNA Intercalators Endowed with Antioxidant and Anticancer Properties
Authors: Aneja Babita , Arif Rizwan , Perwez Ahmad , Napoleon John V. , Hasan Phool , Rizvi M. Moshahid A. , Azam Amir , Rahisuddin  , Abid Mohammad 
Published: March 2018

AbstractDespite the fact that many small molecule inhibitors have been approved for cancer therapy, we still have a mighty long road to traverse in the field of targeted therapy against cancer. In order to overcome the challenges of chemo resistance and selectivity, we designed and synthesized 1,2,3‐triazole appended indole‐chalcone derivatives (4 a‐q) and evaluated their antioxidant, anticancer and DNA binding properties. Among all the analogs, compounds with o‐chloro (4b), o‐fluoro (4h) and p‐fluoro (4j) substitution exhibited potent antioxidant activity and the potency of 4 b was comparable to the standard ascorbic acid. In a cell based screen, compound 4 b inhibited the growth of human cervical cancer (SiHa) and colorectal epithelial carcinoma (SW620) cancer cell lines with an IC50 values of 67.99 and 48.96 μg mL−1, respectively without showing any significant cytotoxicity in human embryonic kidney cells (HEK293) at the similar concentration. To gain insight into the DNA‐binding ability, various spectroscopic techniques such as UV‐visible, fluorescence, circular dichroism, viscosity and cyclic voltametric studies were performed. These studies exposed that compounds 4 b, 4 h and 4 j act via non‐covalent intercalative mode of binding to DNA causing their antiproliferative activity, supported by molecular docking studies. Our study revealed the non‐toxic nature and potent activity of compound 4 b makes it a suitable candidate for further optimization and pharmacological studies.
Cobalt‐Copper Ferrite Nanoparticles Catalyzed Click Reaction at Room‐Temperature: Green Access to 1,2,3‐Triazole Derivatives
Authors: Matloubi Moghaddam Firouz , Pourkaveh Raheleh , Ahangarpour Marzieh 
Published: March 2018

AbstractA typical Cobalt‐Copper ferrite nanoparticles (CoCuFe2O4) was used as a catalyst for one‐pot [3+2] cycloaddition of alkyl azides with alkynes at room temperature in green media. These nanoparticles were synthesized by using co‐precipitation method and were fully characterized by physiochemical technique. By this catalyst system, various types of alkyl halides were coupled with alkynes efficiently to furnish 1,2,3 triazoles in excellent yields within short reaction time. The requirement on energy and time for the Click reaction extremely minimized in this method compared to previously reported reactions as an inevitable trend in development of green chemistry. Using green solvent, inexpensive catalyst, and ability to totally removal of catalyst from reaction media have made this protocol valuable from the green chemistry point of view.
Integrated multi‐type sensor placement and response reconstruction method for high‐rise buildings under unknown seismic loading
Authors: Hu Rongpan , Xu Youlin , Lu Xiao , Zhang Chaodong , Zhang Qilin , Ding Jiemin 
Published: March 2018

SummaryStructural health monitoring system has been implemented on high‐rise buildings to provide real‐time measurement of structural responses for evaluating their serviceability, safety, and sustainability. However, because of the complex structural configuration of a high‐rise building and the limited number of sensors installed in the building, the complete evaluation of structural performance of the building in terms of the information directly recorded by a structural health monitoring system is almost impossible. This is particularly true when seismic‐induced ground motion is unknown. This paper thus proposes an integrated method that enables the optimal placement of multi‐type sensors on a high‐rise building on one hand and the reconstruction of structural responses and excitations using the information from the optimally located sensors on the other hand. The structural responses measured from multi‐type sensors are fused to estimate the full state of the building in the modal coordinates using Kalman filters, from which the structural responses at unmeasured locations and the seismic‐induced ground motion can be reconstructed. The optimal multi‐type sensor placement is simultaneously achieved by minimizing the overall estimation errors of structural responses at the locations of interest to a desired target level. A numerical study using a simplified finite element model of a high‐rise building is performed to illustrate the effectiveness and accuracy of the proposed method. The numerical results show that by using 3 types of sensors (inclinometers, Global Positioning System, and accelerometers), the proposed method offers an effective way to design a multi‐type sensor system, and the multi‐type sensors at their optimal locations can produce sufficient information on the response and excitation reconstruction.
Hybrid Interfaces in Molecular Spintronics
Authors: Forment‐Aliaga Alicia , Coronado Eugenio 
Published: March 2018

AbstractMolecular/inorganic multilayer heterostructures are gaining attention in molecular electronics and more recently in new generation spintronic devices. The intrinsic properties of molecular materials as low cost, tuneability, or long spin lifetimes were the original reasons behind their implementation. However, the non‐innocent role played by these hybrid interfaces is a determinant factor in the device performance. In this account we will give an overview about different types of hybrid molecular system/ferromagnet interfaces, which can be of direct application in molecular spintronics. This includes the insertion of a 2D material in between the molecular system and the ferromagnet. As perspective, new hybrid interfaces able to tune the spin properties under an external stimulus, are proposed. These smart interfaces, based on switchable magnetic molecules or flexible MOFs, can open the way to new multifunctional spintronic devices able to couple the spin with a second property.
Characterization and Correction of Symptomatic Hip Impingement in American Football Linemen
Authors: Ross James R. , Khan Moin , Noonan Benjamin C. , Larson Christopher M. , Kelly Bryan T. , Bedi Asheesh 
Published: March 2018

Background Femoroacetabular impingement (FAI) morphology can lead to range-of-motion deficits in football players. It is therefore important for physicians treating these players to be aware of the location and implications of FAI morphology. Purpose/Questions We sought to characterize the radiographic deformity and dynamic impingement observed in a consecutive series of American football linemen with symptomatic, mechanical hip pain who underwent surgical treatment for FAI and to use software analysis to identify the location of impingement and terminal range of motion and the effects of simulated correction. Methods A retrospective analysis was conducted of 17 hips in 13 football linemen who underwent arthroscopic correction for symptomatic FAI. Computed tomography (CT) scans were used to generate preoperative three-dimensional models of the hips. Femoral and acetabular measurements, maximum hip flexion, abduction, internal rotation at 90° flexion (IR90), and flexion/adduction/internal rotation (FADIR) were determined, and areas of bony collision were defined. Simulated femoral correction was performed and motion analysis was repeated. Results Mean femoral version was 13.1° (range, 0 to 26°), while mean femoral neck-shaft angle was 132.1° (range, 123 to 145°). Mean maximum alpha angle on the radial reformatted CT was 69.2° (range, 48 to 95°) and was located at the 12:45 clock-face position (range, 11:30 to 2:15). Mean acetabular version values at 1:30 and 3:00 were 1.1° (range, − 11 to 11°) and 12.7° (range, 2 to 20°), respectively. Fifty-three percent of hips showed a “crossover” sign. Mean lateral center-edge angle was 31.7° (range, 25 to 44°). CT-derived motion analysis demonstrated a mean preoperative flexion of 108.2° (range, 73 to 127°), IR90 of 20.5° (range, 0 to 52°), and FADIR of 12.3° (range, 0 to 39°). Simulated correction resulted in significant improvements in flexion (6.6°), IR90 (11.3°), and FADIR (10.6°). Conclusions While cephalad retroversion was observed in approximately half of the hips, a significant cam deformity was seen maximally at 12:45, a more posterior cam location than that of the general population. Managing this pathology required obtaining preoperative and intraoperative images to characterize lesions and allow for their complete correction. With complete correction of the deformity, simulated range of motion demonstrated significant improvement in flexion, IR90, and FADIR maneuvers.