bluuebunny/crossref_metadata_2025_split huggingface dataset:
Biofuel‐Driven Stepping Chiral Supramolecular Transfer Container
Authors: Yu Jie , Yu Huijia , Qiu Yugui , Zhang Heng‐Yi , Xu Xiufang , Liu Yu 
Published: November 2024

AbstractHerein, we reported a biofuel‐driven recyclable chiral supramolecular transfer container based on hexacationic triphenylamine cage and nucleotides. Possessing rotatable paddle rigid backbones, the artificial receptor effectively encapsulated nucleotides with a high binding constant up to 5.37×105 M−1 in water, displaying guest‐induced efficient fluorescence enhancement with quantum yield increased from 6.5 % to 16.6 %. Especially, the achiral cage could effectively bind with adenosine triphosphate to activate chirality transfer from substrates to the single molecular container, giving circularly polarized luminescence at 575 nm and positive Cotton effect peaks with significant asymmetric factor (gabs=+6.4×10−4). Meanwhile, the adaptive chiral supramolecule not only has reversible thermal responsiveness but also could stepwise regulate chirality transfer by the catalysis of hexokinase and apyrase in tandem, showing recovery adaptive chirality after refueled, achieving dynamically regulated programmable multistate chiral luminescent supramolecules. Therefore, the biofuel‐driven chiral supramolecular transfer container could be successfully applied in chiral logic gates and multilevel information encryption, providing new insight into intelligent chiral materials.
Diastereoselective Anomeric C(sp3)−H Cyclization Towards the Design of New Cyclophane‐Braced Glycopeptides
Authors: Bazzi Sakna , Hadj Mohamed Ameni , Ryzhakov Dmytro , Ghouilem Juba , Beniddir Mehdi A. , Gandon Vincent , Messaoudi Samir 
Published: November 2024

AbstractHere we report a macrocyclization route towards the synthesis of glycophane peptides by a selective C−H arylation of the anomeric bond. This approach demonstrates the power of Pd‐catalysis C−H activation to access unusual cyclic peptides.
Mitochondrial Viscosity Probes: Iridium(III) Complexes Induce Apoptosis in HeLa Cells
Authors: Chen Bingbing , Liang Zhijun , Gong Yao , Wu Wei , Huang Jiaen , Chen Jiaxi , Wang Yanmei , Mei Jun , Chen Rui , Huang Zunnan , Sun Jing 
Published: November 2024

AbstractMitochondrial viscosity has emerged as a promising biomarker for diseases such as cancer and neurodegenerative disorders, yet accurately measuring viscosity at the subcellular level remains a significant challenge. In this study, we synthesized and characterized three cyclometalated iridium(III) complexes (Ir1‐Ir3) containing 5‐fluorouracil derivatives as ligands. Among these, Ir1 selectively induced apoptosis in HeLa cells by increasing mitochondrial production of reactive oxygen species (ROS), which triggered a cascade of events leading to mitochondrial dysfunction. Additionally, the fluorescence lifetime of Ir1 demonstrated high sensitivity to intracellular viscosity changes, enabling real‐time fluorescence lifetime imaging microscopy (FLIM) of cellular micro‐viscosity during apoptosis. These findings underscore the potential of cyclometalated Ir(III) complexes for both therapeutic and diagnostic applications at the subcellular level.
Frustrated Radical Pairs: From Fleeting Intermediates to Isolable Species
Authors: van der Zee Lars J. C. , Hofman Jelle , Mathew Simon , de Visser Anne , Brück Ekkes , de Bruin Bas , Chris Slootweg J. 
Published: November 2024

AbstractWe present the design and comprehensive investigation of stable para‐substituted triarylamine–2,3‐dichloro‐5,6‐dicyano‐1,4‐benzoquinone (DDQ) radical ion pairs (RIPs) generated via single‐electron transfer (SET). We quantified the degree of SET in both solution and solid phases, utilising a suite of spectroscopic techniques including IR, EPR, NMR, and single‐crystal X‐ray diffraction (SC–XRD). Our findings reveal that the extent of SET is significantly influenced by the nature of the substituents (MeO > tBu > Br) and the polarity of the solvent (MeCN > DCM > toluene). The radical ion pair [(pMeOPh)3N]⋅+[DDQ]⋅− was unambiguously identified using EPR and UV–vis spectroscopy, and its structure was confirmed by SC–XRD. Detailed analysis indicates an open‐shell singlet ground state with a thermally accessible triplet state, as corroborated by EPR, magnetic susceptibility measurements, and DFT calculations. This study offers crucial insights into the mechanistic pathways of RIP formation and tuning both in solution and solid states, laying the groundwork for future exploration of their reactivity and potential applications.
Ortho Arylation of N‐Aryl Amides and the Construction of Diagonal Tetraarylbenzenediamines and N‐Doped Fulminenes via BBr3‐Derived Dibromoboracycles
Authors: Shinde Ganesh H. , Ghotekar Ganesh S. , Sundén Henrik 
Published: November 2024

AbstractThe synthesis of biaryl amides, which are prevalent motifs in bioactive molecules, often necessitates lengthy and inefficient procedures. To address these limitations, catalytic C−H activation protocols have emerged, enabling the direct ortho‐arylation of aryl amides. However, these protocols often suffer from issues such as lack of selectivity, reliance on stoichiometric oxidants, and the requirement for excess reagents and harsh reaction conditions. To overcome these challenges, we present a novel and highly selective protocol for the ortho‐arylation of N‐aryl amides and ureas. The high selectivity originates from the directed installation of BBr3 to form a boracycle, which then undergoes cross‐coupling with an aryl halide. Our method offers significant advantages, including mild reaction conditions, excellent site‐specificity, and scalability. The protocol demonstrates broad compatibility with a diverse range of readily accessible functionalized anilides and aryl iodides, as evidenced by 55 successful examples yielding products in the 30–95 % range. Furthermore, our methodology surpasses conventional approaches by facilitating the one‐pot selective diagonal diarylation of dianilides. This capability unlocks the construction of previously unattainable diagonal aryl systems, which serve as valuable precursors for the synthesis of diagonal tetraarylbenzenediamines and N‐doped fulminenes, two crucial compound classes in materials science.
Charting the temporal evolution of stakeholder involvement in business model for sustainability: A comprehensive bibliometric review
Authors: Attanasio Giovanna , Battistella Cinzia 
Published: November 2024

AbstractThis paper aims to explore and analyse the temporal evolution of the concept of stakeholder involvement, highlighting the transformations, influences, and interpretations that this concept has undergone over the years. The particular setting is business models for sustainability (BMfS). Through in‐depth bibliometric literature review and critical analysis, co‐citation analysis is used to identify the past themes in the topic and bibliographic coupling analysis to explore its recent developments. Future developments of the themes are then outlined. The paper proposes a conceptual framework called Sustainability Strategy Map for Stakeholder Involvement that can help organisations move towards business models for sustainability, acting on purpose, architecture and involvement to achieve outcomes. The goal is to create a detailed map of the evolution of this concept over time, highlighting crucial milestones, controversies, and connections with other key concepts. Major results show that, compared with the past, recent research is more practical, improvement‐oriented, expanded to polluting industries and focused on economic performance. Finally, stakeholder involvement shifted from management and engagement to integration, a deeper and longer connection characterised by a strategic relationship.
New Modulation Technique for a Family of Z‐Source AC–AC Converters With a Safe Commutation Strategy
Authors: Jeelani Naira , Hamid Bhat Abdul 
Published: November 2024

ABSTRACTDirect pulse‐width modulated (PWM) AC–AC converters are rapidly advancing, primarily because of their single‐stage power conversion and reduced footprint, achieved by eliminating the intermediate DC‐link capacitor. Z‐source AC–AC converters (ZSACs) especially have gained attention for their wide voltage range and reduced harmonic currents in applications where only voltage regulation is desired. Meanwhile, voltage regulation in PWM AC–AC converters necessitates effective closed‐loop control methods. Delta‐sigma modulation (DSM) has emerged as a promising technique, outperforming traditional methods. Nevertheless, the conventional DSM technique employs a fixed hysteresis band, resulting in the converter operating at a variable switching frequency. The variable switching frequency increases the switching losses, which puts more thermal stress on the switches. This paper introduces a CSF‐based DSM method for ZSACs that makes use of an adaptive hysteresis band. A four‐step commutation technique is utilized to prevent voltage and current spikes across the bidirectional switches, eliminating the need for snubber circuits. The proposed approach is validated through comprehensive simulation studies and experimental results on a modified quasi‐ZSAC topology using a 200‐W laboratory prototype, demonstrating significant improvements in source and load current total harmonic distortion (THD), dynamic response, and overall system performance while maintaining constant switching frequency.
Plant Species Diversity and Composition Differ Significantly Between the Boundaries of Kettle Holes and Field Borders
Authors: Heyer I. , Wulf M. 
Published: November 2024

ABSTRACTThe boundaries around habitat islands in agricultural fields are rather unexamined, although they may be an important part of agroecosystems in some regions. In this study, we surveyed field boundaries in northeastern Brandenburg both at outer field borders and around kettle holes, which are typical habitat islands in the region. We examined, described, and compared the plant species diversity and composition at both the inner and outer field boundaries in the arable fields (crop edge) as well as in permanent vegetation (field margins). Diversity was assessed and compared with Hill diversity values, using the iNext framework. Non‐metric multidimensional scaling and permutational analysis of variance were used to compare species composition at different field boundaries and to search for variables that drive species composition at the local scale. The results revealed that both species diversity and composition differed significantly between the inner and outer boundary along the crop edges and at the field margins. Local site conditions, namely a moisture gradient, influenced the species composition of the field margins, resulting in differences between the inner and outer field margins. Mitigated through crop growth and cover, the moisture gradient influenced also the species composition of the inner and outer crop edges, despite the management practices on the fields were the same.
Banning protests at oil and gas sites: The influence of policy entrepreneurs and political pressure
Authors: Jang Sojin , Kagan Jennifer A. 
Published: November 2024

AbstractDirect action by citizens has played a pivotal role in shaping environmental policies in the United States. However, several states have recently enacted legislation prohibiting protests at oil and gas project sites, thus undermining the historical legacy of free speech, the American environmental movement, and environmental justice. This study aims to elucidate the determinants influencing the adoption of bills that prohibit civic protests at oil and gas project sites. Existing policy adoption studies have paid limited attention to the impact of policy entrepreneurs and corporate lobbying on policy adoption. This study contributes to the public policy literature by examining the role of the American Legislative Exchange Council (ALEC) and corporate political activities, and how their influence combines with other types of political pressure to influence the adoption of bills that outlaw protests at oil and gas sites (anti‐protest bills) at the state level. Using event history analysis with Cox regression, we modeled the likelihood of adoption of anti‐protest bills across 50 states from 2017 to 2021. Furthermore, to zoom in on a strategy employed by ALEC, we compared the similarity scores between the texts of ALEC model legislation and proposed anti‐protest bills. This study found that the adoption of anti‐protest bills is explained by the presence of ALEC‐tied legislators, the composition of legislatures, gas production, and the oil and gas industry's contribution to the state economy. The influence of ALEC's model legislation in policy adoption, however, is not significant.
Antibiotic‐associated neutropenia is marked by the depletion of intestinal Lachnospiraceae and associated metabolites in pediatric patients
Authors: Fernandez‐Sanchez Josaura , Rodgers Rachel , Maknojia Arushana A. , Shaikh Nusrat , Yan Hannah , Mejia Marlyd E. , Hendricks Hope , Jenq Robert R. , Reddy Pavan , Banerjee Ritu , Schraw Jeremy M. , Baldridge Megan T. , King Katherine Y. 
Published: November 2024

AbstractProlonged antibiotic exposure causes dangerous hematologic side effects, including neutropenia, in up to 34% of patients. Murine studies established a link between the intestinal microbiota and hematopoiesis. To identify factors that predispose to neutropenia in pediatric patients, we evaluated changes in microbiota‐derived metabolites and intestinal microbiota composition after prolonged courses of antibiotics. In this multi‐center study, patients with infections requiring anticipated antibiotic treatment of two or more weeks were enrolled. Stool samples were obtained at the start and completion of antibiotics or at neutropenia onset (prospective arm). Some patients were enrolled in a retrospective arm in which a stool sample was collected at the time of neutropenia during antibiotic therapy and 2–4 weeks after completion of antibiotics with recovery of blood counts. We identified 10 patients who developed neutropenia on antibiotics and 29 controls matched for age, sex, race, and ethnicity. Clinical data demonstrated no association between neutropenia and the type of infection or antibiotic used; however, patients with neutropenia were admitted to the intensive care unit more often and received longer courses of antibiotics. Reduced intestinal microbiome richness and, specifically, decreased abundance of Lachnospiraceae family members correlated with neutropenia. Untargeted stool metabolomic profiling revealed several metabolites that were depleted exclusively in patients with neutropenia, including members of the urea cycle pathway, pyrimidine metabolism, and fatty acid metabolism that are known to be produced by Lachnospiraceae. Our study shows a relationship between intestinal microbiota disruption and abnormal hematopoiesis and identifies taxa and metabolites likely to contribute to microbiota‐sustained hematopoiesis.
Soluble adhesion molecules in serum and peritoneal fluid are associated with pelvic pain in endometriosis
Authors: Ahsan Fadhil , Santoso Budi , Rahmawati Nanda Yuli , Alditia Fidyah Nanda , Mufid Alfin Firasy , Sa'adi Ashon , Dwiningsih Sri Ratna , Tunjungseto Arif , Widyanugraha M. Y. Ardianta 
Published: November 2024

AbstractObjectiveTo investigate the association between soluble adhesion molecules (sE‐cadherin, sE‐selectin, sICAM‐1, sVCAM‐1) in serum and peritoneal fluid and pelvic pain in infertile women with endometriosis.MethodsThis observational study included 86 infertile women undergoing diagnostic laparoscopy, 43 of whom were diagnosed with endometriosis. Pain intensity was evaluated using the visual analog scale (VAS). Levels of soluble adhesion molecules in serum and peritoneal fluid were quantified using ELISA. Statistical analysis included the Mann–Whitney U test for group comparisons, Spearman's rank correlation for associations with VAS scores, and receiver operating characteristic (ROC) curve analysis for diagnostic performance.ResultsSerum sE‐selectin levels were significantly higher in women with pelvic pain (P = 0.022) and correlated with VAS scores (r = 0.271, P = 0.012). Peritoneal sE‐selectin and sICAM‐1 levels were elevated in women with pelvic pain (P = 0.044 and P = 0.029, respectively) and showed positive correlations with VAS scores (r = 0.246, P = 0.022 and r = 0.310, P = 0.004, respectively). Comparing endometriosis and control groups, peritoneal sE‐selectin and sICAM‐1 levels were significantly higher in endometriosis cases with pelvic pain (P = 0.003 and P < 0.001, respectively). ROC analysis revealed the potential diagnostic value of serum sE‐selectin (AUC = 0.698, P = 0.002), serum sICAM‐1 (AUC = 0.721, P < 0.001), and serum sVCAM‐1 (AUC = 0.750, P < 0.001) in distinguishing endometriosis from non‐endometriosis cases.ConclusionElevated levels of sE‐selectin and sICAM‐1 in serum and peritoneal fluid are associated with pelvic pain in women with endometriosis, suggesting their role in pain pathogenesis and potential as biomarkers for pain severity and disease diagnosis. Further research is warranted to explore the underlying mechanisms and validate these findings in larger cohorts.
Performance Analysis of Underwater Acoustic Channel Amid Jamming by Random Jammers
Authors: Aman Waqas , Al‐Kuwari Saif , Qaraqe Marwa 
Published: November 2024

ABSTRACTUnderwater communication networks are increasingly popularized by various important maritime applications. However, this also leads to an increased threat landscape. This letter presents the first study that considers jamming attacks by random jammers present in the surroundings of legitimate transceivers in underwater acoustic communication systems. We investigate the impact of jamming attacks on various performance parameters of the legitimate underwater acoustic communication link. In particular, we investigate the legitimate link using stochastic geometry for important performance parameters, namely coverage probability, average rate, and energy efficiency of the link between two legitimate nodes, that is, underwater and surface nodes. We then derive and present tractable expressions for these performance parameters. Finally, we performed a Monte Carlo simulation to validate our analysis. We plot performance metrics against the transmit power, and jamming power for different intensities of the jammers in shallow, mid, and deep‐water scenarios. Results reveal that on average, jamming in deep water has a relatively high impact on the performance of legitimate link than in shallow water.
Magnetic Resonance Elastography Combined With PI‐RADS v2.1 for the Identification of Clinically Significant Prostate Cancer
Authors: Chen Jie , Chen Yuntian , Chen Guoyong , Deng Liping , Yuan Yuan , Tang Hehan , Zhang Zhen , Chen Tingyu , Zeng Hao , Yuan Enyu , Yin Meng , Chen Jun , Song Bin , Yao Jin 
Published: November 2024

BackgroundMultiparametric MRI may cause overdiagnosis of clinically significant prostate cancer (csPCa) with the Prostate Imaging Reporting and Data System version 2.1 (PI‐RADS v2.1).ObjectivesTo investigate the diagnostic performance of stiffness as a standalone and complementary marker to PI‐RADS v2.1 for diagnosing csPCa.Study TypeProspective.SubjectsOne hundred forty‐seven participants with pathologically confirmed prostate lesions (≥1 cm), including 71 with csPCa.Field Strength/SequenceT1‐weighted fast spin‐echo, T2‐weighted fast spin‐echo, single‐shot echo‐planar diffusion‐weighted imaging, fast 3D gradient‐echo T1‐weighted dynamic contrast‐enhanced imaging, and 3D single‐shot spin‐echo based echo‐planar MR elastography at 3.0 T.AssessmentThe PI‐RADS v2.1 score was assessed by three radiologists independently. Lesion shear stiffness (SS) values at 60 Hz and 90 Hz were measured. A modified PI‐RADS integrating stiffness with PI‐RADS v2.1 was developed. Diagnostic performance for csPCa was compared between stiffness, PI‐RADS v2.1 and the modified PI‐RADS.Statistical TestSpearman's correlation, Fleiss κ and intraclass correlation, Pearson correlation, one‐way analysis of variance, area under the receiver operating characteristic curve (AUC), and the Delong test. Significance level was P < 0.05.ResultsIn the peripheral zone, csPCa (N = 35) had significantly higher SS than non‐csPCa at 60 Hz (3.22 ± 0.66 kPa vs. 2.56 ± 0.56 kPa) and at 90 Hz (5.64 ± 1.30 kPa vs. 4.48 ± 0.84 kPa). PI‐RADS v2.1 showed 100% sensitivity, 58% specificity, and 0.79 AUC for detecting csPCa. SS achieved 97% sensitivity, 52% specificity, and 0.80 AUC at 60 Hz, while SS had 63% sensitivity, 87% specificity, and 0.78 AUC at 90 Hz. The modified PI‐RADS, combing SS at 60 Hz with PI‐RADS v2.1, resulted in a significantly increased AUC (0.86) compared to that of PI‐RADS v2.1, with a sensitivity of 97% and specificity of 75%.Data ConclusionStiffness can help identifying csPCa in the peripheral zone. Combining stiffness with the PI‐RADS v2.1 improved the diagnostic accuracy and specificity for csPCa.Evidence Level1Technical EfficacyStage 2
Optimizing pH and Light for Enhanced Carotenoid Synthesis and Antioxidant Properties in Sub‐Aerial Cyanobacteria
Authors: Singh Lakshmi , Prusty Dibyani , Behera Maheswari , Perveen Kahkashan , Bukhari Najat A. 
Published: November 2024

ABSTRACTCarotenoid, natural pigments, synthesized by plants and microbes are now much favored in global markets due to the awareness of their putative health benefits, and a wide array of commercial applications. There is a diversity of natural and synthetic carotenoid, but only a few of them are commercially produced, including carotenes (β‐carotene and lycopene) and xanthophylls (astaxanthin, canthaxanthin, lutein, zeaxanthin, and capsanthin). However, for commercial production, plants and algae are more favored than cyanobacteria because of their much less carotenoid synthesis than land plants; although they are well known for producing commercially important carotenoid. But with advances in optimization of their carotenoid production, cyanobacteria can be used as a potential source of carotenoid production in the future allowing us to exploit its various applications. Hence, this study investigated the effects of pH and light conditions on carotenoid production in the sub‐aerial cyanobacterium Desertifilum dzianense ON358232.1. The results revealed that the highest carotenoid synthesis occurred under alkaline conditions (pH 9) and red‐light exposure, significantly increasing compared to the control (pH 7.2, white light). UV‐Vis and FTIR analyses confirmed the presence of β‐carotene as the primary carotenoid, demonstrating strong antioxidant potential. The study's findings highlight the optimal environmental parameters for enhancing carotenoid yield, which can be applied for industrial and pharmaceutical uses due to their antioxidant properties.