bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluating the endometabolic and bone health effects of Tyrosine Kinase Inhibitors in Chronic Myeloid Leukaemia: a systematic review protocol
Authors: Balakumaran Janatani , Birk Tanisha , Golemiec Breanne , Helmeczi Wryan , Inkaran Jeyanth , Kao Yun-ya , Leigh Jennifer , Saliba Sarah , Sharma Rishi , Spatafora Laura , Wright Kristin , Yao William , Hillis Christopher , Banfield Laura , Thabane Lehana , Athale Uma , Samaan M Constantine 
Published: September 2019

IntroductionChronic Myeloid Leukaemia (CML) constitutes 15% of new adult leukaemia cases as well as 2%–3% of leukaemia in children under 15% and 9% of leukaemias in adolescents 15–19 years of age annually. The introduction of Tyrosine Kinase Inhibitors (TKI) therapy has dramatically improved survival in these patients, yet the off-target effects of this treatment may have long-term health impacts on CML survivors. The risk of adverse health outcomes is especially important in children, where TKI exposure may occur during critical windows of growth and puberty, and patients require treatment for prolonged periods of time. The aim of this systematic review protocol is to report on the methods used to conduct a systematic review to investigate the endometabolic and bone health effects of TKI therapy in CML.Methods and analysisSearches will be conducted in the Cochrane Central Register of Controlled Trials, EMBASE and MEDLINE from inception on August 1st, 2019. Searches may be updated while performing the systematic review to ensure new evidence is included if applicable. Grey literature search will include ClinicalTrials.gov and ProQuest Dissertations and Theses A&I. We will perform a meta-analysis if there are at least two studies reporting similar populations, interventions, methods and tracking the same outcome measures. The studies should also have similar age and sex distributions.Ethics and disseminationAs this is a systematic review protocol, it does not include patient data; therefore, Research Ethics Board approval is not indicated. The systematic review will be published in a peer-reviewed journal and presented at international conferences.PROSPERO registration numberCRD42018091175.
Fatigue, quality of life and metabolic changes in men treated with first-line enzalutamide versus abiraterone plus prednisolone for metastatic castration-resistant prostate cancer (HEAT): a randomised trial protocol
Authors: Kvorning Ternov Klara , Sønksen Jens , Fode Mikkel , Lindberg Henriette , Kistorp Caroline Michaela , Bisbjerg Rasmus , Palapattu Ganesh , Østergren Peter Busch 
Published: September 2019

IntroductionEnzalutamide and abiraterone acetate plus prednisolone (AAP) are used in combination with androgen-deprivation therapy to further suppress the androgen stimulation of metastatic castration-resistant prostate cancer (mCRPC). First-line mCRPC treatment with enzalutamide and AAP yields similar overall survival and radiographic progression-free survival in phase III trials. Thus, treatment selection relies on patient choice, cost and side effects. The aim of this randomised trial is to investigate differences in fatigue, health-related quality of life (HRQoL) and metabolic side effects in men with mCRPC treated with first-line enzalutamide versus AAP.Methods and analysisIn this ongoing open-label randomised (1:1) clinical trial, enzalutamide is compared with AAP as first-line treatment for men with mCRPC. The primary endpoint is fatigue assessed with the questionnaire Functional Assessment of Chronic Illness Therapy-Fatigue version 4. Secondary endpoints are changes in body composition (ie, fat mass, visceral adipose tissue, subcutaneous adipose tissue and lean body mass assessed with dual energy X-ray absorptiometry), glucose metabolism assessed with a 2-hour oral glucose tolerance test, serum lipids, blood pressure and HRQoL assessed with the questionnaire Functional Assessment of Cancer Therapy-Prostate (FACT-P). All study endpoints are assessed at baseline and 12-week postintervention. Blood and urine samples are collected at baseline and at time of progression on allocated treatment for future investigation of predictive and prognostic biomarkers in prostate cancer treatment. The planned sample size is 170 participants. All participants are recruited from Herlev and Gentofte Hospital, Denmark. Estimated last patient’s last visit is February 2020.Ethics and disseminationThe study received project approval from the National Committee on Health Research Ethics and Danish Data Protection Agency and Danish Medicines Agency (EudraCT no.: 2017-000027-99). The results of the study will be published in peer-reviewed international journals and will be presented at national and international conferences and symposiums.Trial registration numberClinicaltrialsregister.eu (2017-000099-27).
Informed health choices intervention to teach primary school children in low-income countries to assess claims about treatment effects: process evaluation
Authors: Nsangi Allen , Semakula Daniel , Glenton Claire , Lewin Simon , Oxman Andrew D , Oxman Matt , Rosenbaum Sarah , Dahlgren Astrid , Nyirazinyoye Laetitia , Kaseje Margaret , Rose Christopher James , Fretheim Atle , Sewankambo Nelson K 
Published: September 2019

BackgroundWe developed the informed health choices (IHC) primary school resources to teach children how to assess the trustworthiness of claims about the effects of treatments. We evaluated these resources in a randomised trial in Uganda. This paper describes the process evaluation that we conducted alongside this trial.ObjectivesTo identify factors affecting the implementation, impact and scaling up of the intervention; and potential adverse and beneficial effects of the intervention.MethodsAll 85 teachers in the 60 schools in the intervention arm of the trial completed a questionnaire after each lesson and at the end of the term. We conducted structured classroom observations at all 60 schools. For interviews and focus groups, we purposively selected six schools. We interviewed district education officers, teachers, head teachers, children and their parents. We used a framework analysis approach to analyse the data.ResultsMost of the participants liked the IHC resources and felt that the content was important. This motivated the teachers and contributed to positive attitudes. Although some teachers started out lacking confidence, many found that the children’s enthusiasm for the lessons made them more confident. Nearly everyone interviewed thought that the children learnt something important and many thought that it improved their decision-making. The main barrier to scaling up use of the IHC resources that participants identified was the need to incorporate the lessons into the national curriculum.ConclusionThe mostly positive findings reflect the trial results, which showed large effects on the children’s and the teachers’ critical appraisal skills. The main limitations of this evaluation are that the investigators were responsible for both developing and evaluating the intervention.
Interventions and practice models for improving health and psychosocial outcomes of children and young people in out-of-home care: protocol for a systematic review
Authors: Galvin Emma , O'donnell Renée , Skouteris Helen , Halfpenny Nick , Mousa Aya 
Published: September 2019

IntroductionChildren and young people placed in out-of-home care (OoHC) are often affected by a history of trauma and adverse childhood experiences. Trauma in early childhood can impact on children’s health and psychosocial development, whereas early interventions can improve children’s development and placement stability. Although several interventions and practice models have been developed to improve health and psychosocial outcomes for children and young people in OoHC, there remains a lack of rigorous research examining the impact of these interventions in OoHC settings, as there are no systematic reviews examining the impact these interventions and practice models have on the children and young people they serve. We aim to conduct a comprehensive systematic review to examine the effectiveness of interventions and practice models for improving health and psychosocial outcomes in children and young people living in OoHC and to identify relevant knowledge gaps.Methods and analysisMajor electronic databases including Medline, Medline in-process and other non-indexed citations, Embase, Cumulative Index to Nursing and Allied Health Literature, PsycInfo, Sociological Abstracts and all Evidence-Based Medicine Reviews incorporating: Cochrane Database of Systematic Reviews, American College of PhysiciansJournal Club, Database of Abstracts of Reviews of Effects,Cochrane Central Register of Controlled Trials, CochraneMethodology Register, Health Technology Assessment and National Health Service Economic Evaluation Database, will be systematically searched for any studies published between 2008 and 2018 of interventions and practice models developed to improve health and psychosocial outcomes for children and young people in OoHC. Two independent reviewers will assess titles and abstracts for eligibility according to prespecified selection criteria and will perform data extraction and quality appraisal. Meta-analyses and/or metaregression will be conducted where appropriate.Ethics and disseminationThis study will not collect primary data and formal ethical approval is therefore not required. Findings from this systematic review will be disseminated in a peer-reviewed publication and conference presentations.PROSPERO registration numberCRD42019115082.
Reduction in hospitalisations for acute gastroenteritis-associated childhood seizures since introduction of rotavirus vaccination: a time-series and change-point analysis of hospital admissions in England
Authors: Hungerford Daniel James , French Neil , Iturriza-Gómara Miren , Read Jonathan M , Cunliffe Nigel A , Vivancos Roberto 
Published: September 2019

IntroductionThe incidence of severe childhood diarrhoea has fallen substantially following the introduction of rotavirus vaccine in the UK in July 2013. Since children with rotavirus infection may experience febrile and afebrile seizures, we evaluated the impact of rotavirus vaccination on seizure hospitalisations in children in England.MethodsUsing data from Hospital Episode Statistics, we employed interrupted time-series analyses to assess changes in monthly hospital admissions for seizures among children aged <5 years from July 2000 to June 2017. Outcome measures comprised all seizures and febrile seizures, with and without a co-diagnosis of acute gastroenteritis (AGE). Models were adjusted for pneumococcal conjugate vaccine (PCV) introduction. Change-point analysis was used to independently identify step-changes in the time-series.ResultsAmong hospitalised children aged <5 years, the incidence of any seizures and febrile seizures with AGE decreased post-vaccine introduction by 23% (95% CI: 11% to 33%) and 31% (95% CI: 19% to 41%), respectively. For febrile seizures with AGE, a single change-point was identified in July 2013 (95% CI: June 2013 to December 2013). Reductions in seizure incidence were higher during the rotavirus season (49%, 95% CI: 37% to 58%) compared with out-of-season (13%, 95% CI: −4 to 28%) and showed no relation to PCV introduction. There were small reductions in any seizures with any co-diagnosis (4%, 95% CI: 0% to 8%) and in febrile seizures with any co-diagnosis (10%, 95% CI: 2% to 16%).ConclusionRotavirus vaccination has reduced hospitalisations for seizures associated with AGE in England, providing additional evidence of population-level impact of rotavirus vaccination on seizure incidence in high-income countries.
Germline BRCA1 and BRCA2 testing for breast cancer survivors
Authors: Wiggins Jennifer , McLoughlin Anne , George Angela , Ring Alistair , Kemp Zoe 
Published: September 2019

Background For patients with early breast cancer, knowledge of germline BRCA1/2 status increasingly influences management as well as informing future cancer risk for patients and their families. As access to germline testing expands, it is important that this benefit is extended to survivors as well as to the newly diagnosed.Methods In collaboration with our breast unit colleagues and by embedding a Senior Genetic Counsellor in the virtual multidisciplinary meeting, we identified patients suitable for genetics review 5 years after their breast cancer diagnosis.Results Between May 2015 and December 2018, 2044 patients were discussed, of whom 769 patients were identified for notes review by Genetics. Of these, 275 had already undergone testing and 47 had confirmed germline pathogenic variants in BRCA1/2. A further 463 were recommended for referral. One hundred and eighty patients were subsequently offered testing with 161 accepting (161/180, 89%). Nine patients were found to harbour pathogenic variants in either BRCA1 or BRCA2 (9/161, 6%). Of the initial 2044 patients reviewed, 2.7% (56/2044) are now known to carry germline pathogenic variants.Conclusion The survivorship setting provides an opportunity for genetic review underpinned by collaborative working between cancer specialists and the genetics team.
Seasonality and global public interest in psoriasis: an infodemiology study
Authors: Wu Qian , Xu Zhiwei , Dan Yi-Lin , Zhao Chan-Na , Mao Yan-Mei , Liu Li-Na , Pan Hai-Feng 
Published: September 2019

AbstractObjectiveAlthough patients with psoriasis frequently report seasonal changes in their symptoms, the seasonality of psoriasis has rarely been explored. This study aims to investigate the seasonal pattern of and global public interest in psoriasis using Google search data.MethodsInternet search data were collected from Google Trends. Data on the relative search volume (RSV) from January 2004 to December 2018 were retrieved using the term psoriasis. Cosinor analyses were conducted to examine the seasonality of psoriasis using data from two southern hemisphere countries (Australia and New Zealand) and four northern hemisphere countries (USA, Canada, UK and Ireland).ResultsOverall, searches for psoriasis steadily decreased between 2004 and 2010, and then rose from 2011 to 2018. On cosinor analyses, RSV of ‘psoriasis’ displayed a significant seasonal variation worldwide (p&lt;0.025). Further analyses confirmed the seasonality of psoriasis-related RSV in Australia, New Zealand, USA, Canada, UK and Ireland (p&lt;0.025 for all), with peaks in the late winter/early spring months and troughs in the late summer/early autumn months. The top 11 rising topics were calcipotriol/betamethasone dipropionate, ustekinumab, apremilast, shampoo, eczema, guttate psoriasis, seborrhoeic dermatitis, dermatitis, psoriatic arthritis, atopic dermatitis and arthritis.ConclusionThere was a significant seasonal pattern for psoriasis, with peaks in the late winter/early spring and troughs in the late summer/early autumn. Further studies are warranted to confirm the seasonal pattern of psoriasis using clinical data and to explore the underlying mechanisms.
Healthcare providers and community perspectives on expedited partner therapy (EPT) for use with gay, bisexual and other men who have sex with men
Authors: Gamarel Kristi E , Mouzoon Raha , Rivas Alejandro , Stephenson Rob , Mmeje Okeoma 
Published: September 2019

ObjectivesExpedited partner therapy (EPT) is an effective strategy to reduce rates of chlamydia and gonorrhoea infection and ensure sexual partners are treated. Currently, EPT is provided to heterosexual patients; however, EPT is not routinely recommended for use with gay, bisexual and other men who have sex with men (GBMSM) because of concerns about HIV coinfection. The objective of the qualitative study was to understand provider and community views on the use of EPT with GBMSM.MethodsUsing convenience sampling methods, we recruited a sample of 18 healthcare providers and 21 GBMSM to participate in in-depth, semistructured interviews. Interviews were conducted over the phone and included questions about knowledge, experiences and potential barriers and facilitators to the use of EPT with GBMSM.ResultsMost providers wanted to provide EPT to GBMSM and believed that the potential barriers and concerns to EPT use were not unique to a patient’s sexual orientation. Several providers noted that they were currently providing EPT to GBMSM as part of HIV prevention services. Community members were generally unaware of EPT as a service and most indicated that they would only use EPT if they were in a committed relationship. Barriers included partner allergies and resistance, pharmacy protocols, structural concerns (eg, insurance coverage, pharmacists onsite and transportation) and potential disclosure issues. Facilitators included cultural humility and telemedicine with patients’ partners to overcome these barriers.ConclusionsAcceptability of EPT use for both chlamydia and gonorrhoea was high among providers and community members. Barriers to EPT use, including concerns about patients’ partners’ allergies and resistance, disclosure concerns and linkage to HIV prevention services can be overcome through cultural humility trainings and telemedicine. Changing EPT recommendations at the national level to be inclusive of GBMSM is critical to curtail the rising STI and HIV epidemic.
Conditioning equine athletes on water treadmills significantly improves peak oxygen consumption
Authors: Greco‐Otto Persephone , Bond Stephanie , Sides Raymond , Bayly Warwick , Leguillette Renaud 
Published: September 2019

Equine water treadmills (WT) were initially designed for rehabilitation of musculoskeletal injuries, but are also commonly used for conditioning sport horses, however the effects are not well documented. The purpose of this study was to test the effect of an 18‐day WT conditioning programme on peak oxygen consumption (V̇O2peak). Nine unfit Thoroughbreds were used in a randomised controlled trial. Six horses worked daily for 18 days in stifle‐height water (WT group), while 3 control horses worked without water (dry treadmill group (DT)). Preconditioning and postconditioning maximal exercise racetrack tests (800 m) were performed using a portable ergospirometry system. Measured outcomes were V̇O2, tidal volume, minute ventilation, breathing frequency, heart rate, blood lactate and instantaneous and average speed. The workload as assessed by V̇O2was 21.7 per cent of preconditioning V̇O2peak values for WT horses. V̇O2peak on the racetrack increased by 16.1 per cent from preconditioning to postconditioning in the WT horses (P=0.03), but did not change in the DT horses. Therefore, exercising horses in high water heights may improve conditioning.
Statistical properties of thermally expandable particles in soft-turbulence Rayleigh-Bénard convection
Authors: Alards Kim M. J. , Kunnen Rudie P. J. , Clercx Herman J. H. , Toschi Federico 
Published: September 2019

Abstract.
The dynamics of inertial particles in Rayleigh-Bénard convection, where both particles and fluid exhibit thermal expansion, is studied using direct numerical simulations (DNS) in the soft-turbulence regime. We consider the effect of particles with a thermal expansion coefficient larger than that of the fluid, causing particles to become lighter than the fluid near the hot bottom plate and heavier than the fluid near the cold top plate. Because of the opposite directions of the net Archimedes’ force on particles and fluid, particles deposited at the plate now experience a relative force towards the bulk. The characteristic time for this motion towards the bulk to happen, quantified as the time particles spend inside the thermal boundary layers (BLs) at the plates, is shown to depend on the thermal response time, $ \tau_{T}$τT, and the thermal expansion coefficient of particles relative to that of the fluid, $ K = \alpha_{p}/\alpha_{f}$K=αp/αf. In particular, the residence time is constant for small thermal response times, $ \tau_{T} \lesssim 1$τT≲1, and increasing with $ \tau_{T}$τT for larger thermal response times, $ \tau_{T} \gtrsim 1$τT≳1. Also, the thermal BL residence time is increasing with decreasing K. A one-dimensional (1D) model is developed, where particles experience thermal inertia and their motion is purely dependent on the buoyancy force. Although the values do not match one-to-one, this highly simplified 1D model does predict a regime of a constant thermal BL residence time for smaller thermal response times and a regime of increasing residence time with $ \tau_{T}$τT for larger response times, thus explaining the trends in the DNS data well.

Graphical abstract
User involvement in building design – a state-of-the-art review
Authors: Caixeta Michele Caroline Bueno Ferrari , Tzortzopoulos Patrícia , Fabricio Márcio Minto 
Published: September 2019

This paper reports results of a systematic literature review on the definitions and levels of user involvement in the design process. Although many studies have highlighted the importance of user involvement for the quality of both process and final product, the term still lacks a clear definition and different models describe diverse involvement levels, which are detrimental to the advancement of knowledge in the area. The present study focused on the mapping of definitions of user involvement and comparisons of the different proposals of involvement levels for outlining a clear definition of the term, based on the levels of involvement, and contributing to the consolidation of the theory of user involvement in the field of architectural design. Moreover, this research assists architects to find the most appropriate level of user involvement for the design they are developing, improving the practice of involving users in the design process.
Variable Presentations and Ablation Sites for Manifest Nodoventricular/Nodofascicular Fibers
Authors: Nazer Babak , Walters Tomos E. , Dewland Thomas A. , Naniwadekar Aditi , Koruth Jacob S. , Najeeb Osman Mohammed , Intini Anselma , Chen Minglong , Biermann Jurgen , Steinfurt Johannes , Kalman Jonathan M. , Tanel Ronn E. , Lee Byron K. , Badhwar Nitish , Gerstenfeld Edward P. , Scheinman Melvin M. 
Published: September 2019

Background:
Nodofascicular and nodoventricular (NFV) accessory pathways connect the atrioventricular node and the Purkinje system or ventricular myocardium, respectively. Concealed NFV pathways participate as the retrograde limb of supraventricular tachycardia (SVT). Manifest NFV pathways can comprise the anterograde limb of wide-complex SVT but are quite rare. The purpose of this report is to highlight the electrophysiological properties and sites of ablation for manifest NFV pathways.

Methods:
Eight patients underwent electrophysiology studies for wide-complex tachycardia (3), for narrow-complex tachycardia (1), and preexcitation (4).

Results:
NFV was an integral part of the SVT circuit in 3 patients. Cases 1 to 2 were wide-complex tachycardia because of manifest NFV SVT. Case 3 was a bidirectional NFV that conducted retrograde during concealed NFV SVT and anterograde causing preexcitation during atrial pacing. NFV was a bystander during atrioventricular node re-entrant tachycardia, atrial fibrillation, atrial flutter, and orthodromic atrioventricular re-entrant tachycardia in 4 cases and caused only preexcitation in 1. Successful NFV ablation was achieved empirically in the slow pathway region in 1 case. In 5 cases, the ventricular insertion was mapped to the slow pathway region (2 cases) or septal right ventricle (3 cases). The NFV was not mapped in cases 5 and 7 because of its bystander role. QRS morphology of preexcitation predicted the right ventricle insertion sites in 4 of the 5 cases in which it was mapped. During follow-up, 1 patient noted recurrent palpitations but no documented SVT.

Conclusions:
Manifest NFV may be critical for wide-complex tachycardia/manifest NFV SVT, act as the retrograde limb for narrow-complex tachycardia/concealed NFV SVT, or cause bystander preexcitation. Ablation should initially target the slow pathway region, with mapping of the right ventricle insertion site if slow pathway ablation is not successful. The QRS morphology of maximal preexcitation may be helpful in predicting successful right ventricle ablation site.