bluuebunny/crossref_metadata_2025_split huggingface dataset:
Investigation of perioperative work processes in provision of antibiotic prophylaxis: a prospective descriptive qualitative study across surgical specialties in Norway
Authors: Wæhle Hilde Valen , Harthug Stig , Søfteland Eirik , Sevdalis Nick , Smith Ingrid , Wiig Siri , Aase Karina , Haugen Arvid Steinar 
Published: June 2019

ObjectiveSurgical site infections are known postoperative complications, yet the most preventable of healthcare-associated infections. Correct provision of surgical antibiotic prophylaxis (SAP) is crucial. Use of the WHO Safe Surgical Checklist (SSC) has been reported to improve provision of SAP, and reduce infections postoperatively. To understand possible mechanisms and interactions generating such effects, we explored the underlying work processes of SAP provision and SSC performance at the intersection of perioperative procedures and actual team working.DesignAn ethnographic study including observations and in-depth interviews. A combination of deductive and inductive content analysis of the data was conducted.SettingOperating theatres with different surgical specialities, in three Norwegian hospitals.ParticipantsObservations of perioperative team working (40 hours) and in-depth interviews of 19 experienced perioperative team members were conducted. Interview participants followed a maximum variation purposive sampling strategy.ResultsAnalysis identified provision of SAP as a process of linked activities; sequenced, yet disconnected in time and space throughout the perioperative phase. Provision of SAP was handled in relation to several interactive factors: preparation and administration, prescription accuracy, diversity of prescription order systems, patient-specific conditions and changes in operating theatre schedules. However, prescription checks were performed either as formal SSC reviews of SAP items or as informal checks of relevant documents. In addition, use of cognitive reminders and clinical experiences were identified as mechanisms used to enable administration of SAP within the 60 min timeframe described in the SSC.ConclusionProvision of SAP was identified as a complex process. Yet, a key element in provision of SAP was the given 60 min. timeframe of administration before incision, provided in the SSC. Thus, the SSC seems beneficial in supporting timely SAP administration practice by either being a cognitive tool and/or as a cognitive intervention.
Venous thromboembolism incidence in the Ireland east hospital group: a retrospective 22-month observational study
Authors: Kevane Barry , Day Mary , Bannon Noirin , Lawler Leo , Breslin Tomas , Andrews Claire , Johnson Howard , Fitzpatrick Michael , Murphy Karen , Mason Olivia , O’Neill Annemarie , Donohue Fionnuala , Ní Áinle Fionnuala 
Published: June 2019

ObjectivesTo determine the incidence of venous thromboembolism (VTE) and the incidence of hospital-acquired VTE (HA-VTE) arising within the population served by the Ireland East Hospital Group (IEHG).Design/home/user/Documents/Sathish Kumar G/RFO/June/21-06-2019/bmjopen_iss_9_7_20190621_1/ A retrospective observational study was conducted using hospital discharge data obtained from the hospital inpatient enquiry data reporting system. In this system, VTE events recorded as ‘primary diagnosis’ represented the reason for initial hospital admission, whereas VTE recorded as a ‘secondary diagnosis’ occurred following admission and were therefore used as an approximation of HA-VTE. These data were used to estimate the overall incidence of VTE and the proportion of these events which were hospital-acquired.SettingThe IEHG is the largest hospital group in the Irish healthcare system and serves a population of over 1 million individuals.ParticipantsData were generated from records pertaining to the 2727 patient admission episodes where a diagnosis of VTE was made during the 22-month study period.ResultsDuring the study period, 2727 VTE events were recorded within the IEHG (which serves a population of 1 036 279) corresponding to an incidence of 1.44 (95% CI 1.36 to 1.51) per 1000 per annum. 1273 (47%) of VTE events were recorded as secondary VTE. The incidence of VTE was highest among individuals over 85 years of age (16.03 per 1000;95% CI 12.81 to 19.26) and was more common following emergency hospital admission.ConclusionThese data suggest that HA-VTE accounts for at least 47% of all VTE events arising within a hospital group serving a population of over 1 million individuals within the Ireland. Given that HA-VTE is a well-recognised source of (potentially preventable) hospital deaths, these findings provide a compelling argument for prioritising strategies directed at reducing the risk of VTE among hospital patients served by the IEHG and within the Ireland as a whole.
Turf Toe Review
Authors: Chiou Daniel , Stupay Kristen L. , Waryasz Gregory 
Published: June 2019

Turf toe is a term used to describe myriad injuries to the metatarsophalangeal complex of the great toe, which have been associated with the introduction of artificial turf surfaces in sport. If not diagnosed early and treated properly, these injuries can result in chronic pain and loss of mobility. Accurate injury grading through physical exam and advanced imaging is essential to guide treatment, thereby minimizing long-term complications and maximizing an athlete’s recovery and return to play. Levels of Evidence: Level V
Genetic Risk Score in Diabetes Associated With Chronic Pancreatitis Versus Type 2 Diabetes Mellitus
Authors: Goodarzi Mark O. , Nagpal Tanvi , Greer Phil , Cui Jinrui , Chen Yii-Der I. , Guo Xiuqing , Pankow James S. , Rotter Jerome I. , Alkaade Samer , Amann Stephen T. , Baillie John , Banks Peter A. , Brand Randall E. , Conwell Darwin L. , Cote Gregory A. , Forsmark Christopher E. , Gardner Timothy B. , Gelrud Andres , Guda Nalini , LaRusch Jessica , Lewis Michele D. , Money Mary E. , Muniraj Thiruvengadam , Papachristou Georgios I. , Romagnuolo Joseph , Sandhu Bimaljit S. , Sherman Stuart , Singh Vikesh K. , Wilcox C. Mel , Pandol Stephen J. , Park Walter G. , Andersen Dana K. , Bellin Melena D. , Hart Phil A. , Yadav Dhiraj , Whitcomb David C. ,   on behalf of the Consortium for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer (CPDPC)
Published: June 2019

Introduction:Diabetes mellitus (DM) is a complication of chronic pancreatitis (CP). Whether pancreatogenic diabetes associated with CP-DM represents a discrete pathophysiologic entity from type 2 DM (T2DM) remains uncertain. Addressing this question is needed for development of specific measures to manage CP-DM. We approached this question from a unique standpoint, hypothesizing that if CP-DM and T2DM are separate disorders, they should be genetically distinct. To test this hypothesis, we sought to determine whether a genetic risk score (GRS) based on validated single nucleotide polymorphisms for T2DM could distinguish between groups with CP-DM and T2DM.Methods:We used 60 T2DM single nucleotide polymorphisms to construct a weighted GRS in 1,613 subjects from the North American Pancreatitis Study 2 and 2,685 subjects from the Multi-Ethnic Study of Atherosclerosis, all of European origin.Results:The mean GRS was identical between 321 subjects with CP-DM and 423 subjects with T2DM (66.53 vs 66.42,P= 0.95), and the GRS of both diabetic groups was significantly higher than that of nondiabetic controls (n = 3,554,P< 0.0001). Exploratory analyses attempting to enrich the CP-DM group for pancreatogenic diabetes, such as eliminating diabetes diagnosed before CP, requiring pancreas-specific comorbidities, or removing those with a family history of diabetes, did not improve the ability of the GRS to distinguish between CP-DM and T2DM.Discussion:Recognizing that we lacked a gold standard to define CP-DM, our study suggests that CP-DM may be a subtype of T2DM, a notion that should be tested in future, large prospective studies.
On the order sequence of an embedding of the Ree curve
Authors: Skabelund Dane C. 
Published: June 2019

Abstract
In this paper we compute the Weierstrass order-sequence associated with a certain linear series on the Deligne–Lusztig curve of Ree type. As a result, we show that the set of Weierstrass points of this linear series consists entirely of 𝔽
q
-rational points.
Using the hemoglobin-binding Staphylococcus aureus protein IsdH to enable plasma analysis of hemolyzed blood samples
Authors: Sæderup Kirstine Lindhardt , Revsholm Jesper , Richardt Patrick Bjork , Christiansen Stig Hill , Hennig Dorle , Moestrup Søren Kragh , Graversen Jonas Heilskov 
Published: June 2019

Abstract

Background
Intravascular hemolysis and in vitro hemolysis are prevalent contributors to failed blood sample analysis in the routine hospital laboratory. Interferences by hemoglobin in spectrophotometric and certain enzyme activity assays is the major causative factor.

Methods
By exploiting the hemoglobin-binding properties of the iron-regulated surface determinant H (IsdH) protein from Staphylococcus aureus we have developed a new method to instantly remove hemoglobin and hemoglobin-haptoglobin complexes from plasma in vitro thereby enabling the measurement of hemoglobin-sensitive analytes in hemolyzed plasma. In the present study we used an engineered IsdH mutant form conjugated to Sepharose for the efficient removal of plasma hemoglobin in concentrations up to 15 mg/mL. The high abundance of haptoglobin, which forms a tight complex with hemoglobin in plasma, did not affect the hemoglobin removal by IsdH Sepharose.

Results
Applying the method on plasma samples that beforehand were spiked with blood hemolysate re-enabled measurement of the hemolysis sensitive parameters: alkaline phosphatase, conjugated bilirubin, iron, ferritin, γ-glutamyltransferase, total thyroxine and troponin T. IsdH Sepharose-mediated hemoglobin removal also enabled measurement of hemolysis sensitive parameters in hemolyzed samples from anonymized patients.

Conclusions
In conclusion, IsdH Sepharose is a simple cost-effective pretreatment of hemolyzed samples correcting and enabling the measurement of several important hemoglobin-sensitive parameters in a way compatible with standard procedures in routine laboratories.
Repairs and old-age categorisations: interactional and categorisation analysis
Authors: Charalambidou Anna 
Published: June 2019

AbstractThis paper examines the use of self-repairs in ascribing old-age categorisations to self and others in casual interactions among friends. Membership categorisation analysis and conversation analysis are employed to analyse self-recorded, everyday conversations of a group of older Greek Cypriot women with a long interactional history. The interactional organisation of old-age labels, and specifically instances of self-repair of age categorisations, reveal that members orient to old-age categories as hierarchically positioned and inference-rich. Members make relevant a very intricate set of expectations of who can be categorised by whom, with what specific age category term and at which context, partly because other-categorisations can also implicate one’s self-categorisation as old. Sequential and categorisation analyses provide a powerful analytical toolkit for the investigation of participants’ local system of self- and other-ascription of explicit -but also implicit- age identities. It is shown that the combination of membership categorisation analysis and conversation analysis can be extended beyond the analysis of turn-generating categories and can be instrumental in analysing flexible, context-shaped and agentively managed category identifications that also have currency beyond the local interactional occasion.
Agency and epistemic authority in question-answer sequences between art museum guides and visitors diagnosed with dementia
Authors: Isaac Adrienne R. , Hamilton Heidi E. 
Published: June 2019

AbstractRecent studies documenting the real-time details of human interactions have revealed the way in which artefacts in the immediate physical surround facilitate the display and demonstration of knowledge. The museum setting in which physically present objects prompt and support visitor displays of knowledge is particularly well-suited for individuals managing symptoms related to memory loss as a result of dementia, especially of the Alzheimer’s type. In this paper, we explore question-answer sequences taken from three hour-long guided sessions within an art gallery program involving museum guides who were specially trained to work with visitors with dementia. We investigate representative sequences 1) in which visitors exercise interactional control by posing questions to guides that relate to the visitors’owninterests and 2) in which guides pose questions to visitors regarding topics that relate to the visitors’ personal lives. We argue that these two discursive practices promote interactional meaningfulness, in that the former pattern affords the visitors interactional agency, while the latter pattern allows them to display their epistemic authority. Finally, we consider how insights from this therapeutic model may be translated from the museum to the home setting.
Indications and outcomes of splenectomy for hematological disorders
Authors: Ciftciler Rafiye , Pasayeva Aysel , Aksu Salih , Ozcebe Osman , Sayınalp Nilgun , Malkan Umit Yavuz , Buyukasık Yahya , Haznedaroglu Ibrahim C. 
Published: June 2019

Abstract

Background and Aim
Splenectomy is a frequent component of the diagnosis and treatment of hematological disorders. The aim of this study was to define the indications and outcomes of splenectomy for benign and malign hematological disorders.

Materials and Methods
One hundred and two patients with hematological disease who had splenectomy at Hacettepe University Hospital between the years of 2010 and 2018 were evaluated.

Results
A total of one hundred and two patients were included in this study. The median age was 52 (20-82) years at the time of splenectomy. Most of the patients were female (57.9%). The median follow up time was 11.0 (0.03-87.9) months after splenectomy. Splenectomy was performed to diagnose thirty patients (29.4%). Seventy-two patients underwent splenectomy for the treatment of hematological disease (70.6%). Twenty-seven patients (90%) were diagnosed with various lymphomas. Two patients (6.7%) were diagnosed with hairy cell leukemia and one patient (3.3%) was diagnosed with large granular lymphocytic leukemia.

Conclusion
In conclusion, an improvement in medical therapy, especially with monoclonal antibodies, the indications and outcomes of splenectomy for hematologic disorders have changed extremely in last years. Nevertheless, splenectomy has an important role for diagnosis and treatment of benign and malign hematological disorders.
Investigations into the mechanisms of electrohydrodynamic instability in free surface electrospinning
Authors: Jiang Guojun , Johnson Lee , Xie Sheng 
Published: June 2019

AbstractFree surface electrospinning is a continuous electrospinning method for low-cost, massive production of nanofibers. The interjet distanceλis a critical parameter in free surface electrospinning, which directly determines the nanofiber production efficiency. In this investigation, we studied the interjet distance during free surface electrospinning based on electrohydrodynamic instability theoretically and experimentally, with special interest focused on the effect of surface tension and electric field intensity on the interjet distance. The experimental results indicated that the critical parameters affecting the interjet distance were the surface tension and applied voltage, which was in good compliance with the theoretical prediction. The relationship between interjet distanceλand surface tension followed an allometric law with positive exponential function, and the relationship between interjet distanceλand applied voltage followed an allometric law with negative exponential function. The present results can be used to understand the basic parameters which determine the interjet distance in free surface electrospinning.
Gendergerechte Bewegungsförderung bei älteren Männern
Authors: Tittlbach Susanne , Strobl Helmut 
Published: June 2019

Zusammenfassung
Männer verzeichnen im Vergleich zu Frauen einen stärkeren Rückgang an Bewegung im Alter und stellen eine vulnerable Zielgruppe der Bewegungsförderung dar. Von bestehenden Bewegungsangeboten werden ältere Männer oft nicht gut erreicht. Erfolgreiche Angebote für ältere Männer müssen daher genderorientiert sein, d.h. gesellschaftlich geprägte Vorstellungen über Männlichkeit aufgreifen, diese aber mit gesundheitlichen Praktiken und einem im Alter verminderten Fitness-Zustand in Einklang bringen.
Geschlechts- und genderspezifische Aspekte der Arzneimittelversorgung
Authors: Glaeske Gerd 
Published: June 2019

Zusammenfassung
In der Arzneimittelversorgung zeigen sich seit vielen Jahren relativ konstant Unterschiede in der geschlechtsspezifischen Verteilung bestimmter Medikamentengruppen. Auffällig ist zum Beispiel die eher leitliniengerechte Verordnung von Arzneimitteln in der Sekundärprävention von Koronarer Herzkrankheit für Männer und die vergleichsweise häufigere Verordnung von Psychopharmaka für Frauen, die oftmals nicht mit den Empfehlungen zur Vermeidung einer inadäquaten Medikation für ältere Menschen übereinstimmt.
Muslim doctors in Catholic hospitals: a challenge for the Christian profile?
Authors: Arens Thorsten 
Published: June 2019

AbstractThis work won the IGGS Research Award 2018. It was published in 2018 as: "Christliches Profil und muslimisches Personal. Katholische und muslimische Ärzte in Caritas-Krankenhäusern" by Kohlhammer, Stuttgart.The increased immigration in Germany since 1949 has resulted in around four million Muslims settling there. Some of them are employed by churches, particularly as doctors in Catholic hospitals. At the same time, church leaders are demanding a clear, recognisable Christian profile for these institutions. What does this mean and what are the resulting challenges for the Christian profile with regard to a Muslim workforce? These highly topical and hitherto scientifically unanswered questions have been addressed in a qualitative study, in which the answers of six Catholic and six Muslim physicians with different medical specialisations in different Caritas hospitals are assigned to the categories of the three-level-model of the Christian profile. Among other things, the evaluations lead to the following result: Neither the coexistence of Catholic and Muslim physicians nor the headscarves of Muslim women prove to be a challenge in hospitals. It is rather framework conditions in the healthcare system that create problems and conflict with Christian requirements. One of the final recommendations is therefore that the people responsible for the framework provide conditions in which Catholic and Muslim physicians can credibly fulfil the requirements of the Christian mission. The results of the study also illustrate the necessity for a constant thematisation of the Christian foundation of faith as well as of church employment law. Therefore, physicians are able to understand, support and discuss Christian ideas on norms and morals as well as church framework requirements.
Thiadiazole-2-Thiol-5-Thione and 2,5-Dimercapto-1,3,4-Thiadiazol Tautomerism, Conformational Stability, Vibrational Assignments, Inhibitor Efficiency and Quantum Chemical Calculations
Authors: Esmaiel Muhammad H. , Basuony Hany A. , Al-Nawasany Mohamed K. , Shulkamy Musab M. , Shaaban Ibrahim A. , Abuelela Ahmed M. , Zoghaib Wajdi M. , Mohamed Tarek A. 
Published: June 2019

Abstract
Raman (3700–100 cm−1) and infrared (4000–400 cm−1) spectra of 2,5-Dimercapto-1,3,4-thiadiazol (DMTD) were recorded in the solid phase. Six structures (1–6) were initially proposed for DMTD as a result of thiol-thione tautomerism and internal rotation(s) of thiol group(s) around the C–S bond. Quantum chemical calculations were carried out for an isolated molecule (1–6) using density functional theory (B3LYP) and ab initio MP2(full) methods utilizing 6-31G(d) and 6-311++G(d,p) basis sets which favor thiol-thione tautomerism (structure 4). Relaxed potential energy surface scans of structure 4 revealed an additional conformer (the thiol group is out-of-plane, structure 7) using the aforementioned methods at 6-311++G(d,p) basis set. For additional verification, plane-wave solid state calculations were carried out at PW91 and PBEsol came out in favor of conformer 7. This is in agreement with the computed/observed SH in-plane bending of S-7 (959/941 cm−1) rather than the one estimated at (880 cm−1) for S-4. Moreover, the observed split IR/Raman bands were found consistent with solid state calculated frequencies of S-7 assuming two molecules per unit cell bonded via H-bonding intermolecular interactions. Aided by vibrational frequency calculations, normal coordinate analysis, force constants and potential energy distributions (PEDs), a complete vibrational assignment for the observed IR and Raman bands is proposed herein. Furthermore, we have estimated the frontier molecular orbitals and atomic charges to account for the corrosion inhibition efficiency of DMTD along with its binding sites to the metal surface. Our results are discussed herein and compared to similar molecules whenever appropriate.
Comparative Effects of Game Profile–Based Training and Small-Sided Games on Physical Performance of Elite Young Soccer Players
Authors: Dello Iacono Antonio , Beato Marco , Unnithan Viswanath 
Published: June 2019

Abstract
Dello Iacono, A, Beato, M, and Unnithan, V. Comparative effects of game profile–based training and small-sided games on physical performance of elite young soccer players. J Strength Cond Res 35(10): 2810–2817, 2021—This study was designed to investigate and compare the effects of game profile–based training (GPBT) and small-sided game (SSG) training on physical performances of elite youth soccer players during the in-season period. Twenty young soccer players (18.6 ± 0.6) were randomly assigned to either GPBT or SSG protocols performed twice a week for 8 weeks. The GPBT consisted of 2 sets of 6–10 minutes of intermittent soccer-specific circuits. The SSG training consisted of 3–5 sets of 5 vs. 5 SSGs played on a 42 × 30-m pitch. Before and after the training program, the following physical performances were assessed: repeated sprint ability, change of direction (COD), linear sprinting on 10 m and 20 m, countermovement jump, and intermittent running (YYIRL1). Significant improvements were found in all the assessed variables after both training interventions (p < 0.05). The GPBT group improved more than the SSG group in the 10-m and 20-m sprint tests by 2.4% (g = 0.4; small effect) and 4% (g = 0.9; large effect), respectively. Conversely, the SSG group jumped 4% higher (g = 0.4; small effect) and resulted 6.7% quicker than the GPBT (g = 1.5; large effect) in completing the COD task. These results suggest both GPBT and SSGs to be effective for fitness development among elite young soccer players during the competitive season. More importantly, these 2 conditioning methodologies may be considered in terms of specificity for selectively improving or maintaining specific soccer fitness-related performances in the latter phase of the season.