bluuebunny/crossref_metadata_2025_split huggingface dataset:
“Fast Women”
Authors: Chen Eva 
Published: November 2024

Abstract
I discuss the rise of an accelerating modern speed culture and locate the New Woman typist and cyclist as new players in this speed culture. The typewriter and the bicycle are not just twin machines of female emancipation, but also technologies of speed subjecting middle-class women to the discipline of mechanized speed while also allowing for possibilities of a new, modern means of individuation. I discuss women’s traditional alienation from technology and speed, and the pitfalls and excitement facing women as they interact with the typewriter and the bicycle. In this interaction we can see the working of speed along three fronts: that of speed as discipline and tightened control (typewriting), as commodity and conspicuous display (cycling), and as rejuvenation and excitement (typewriting and cycling). Speed is what makes the New Woman new.
“The Literary Piano”
Authors: Chen Eva 
Published: November 2024

Abstract
Typewriting threatens to turn the typewriting girl into a mindless automaton, as its unique “blind” trait means that the fastest speed is achieved by not looking at the lines but working purely from memory and the triggering of appropriate muscles and nerves. But a comparison with the piano, another machine also associated with middle-class women, suggests that agentic creativity can be accelerated by mechanical power. This chapter further considers the perceived polarity between the typewriter girl and the creative writer by reading Allen’s The Type-Writer Girl and some magazine stories. It argues for a less deterministic view of typewriting speed that collapses this polarity and allows for some agentic maneuver and readjustment.
Venus on Wheels
Authors: Chen Eva 
Published: November 2024

Abstract
Speed takes on a new role as commodity and conspicuous display with the rise of commodity culture. This is best incarnated in the New Woman cyclist, her fashionable speeding body an iconic image of the mid-1890s “bicycle craze.” The bicycle was the most widely advertised durable luxury product of the time, and the speeding New Woman cyclist, once so transgressive to conservative eyes, is subsumed under a consumerist framework and equated with glamor, fashion, and middle-class status. Bicycle speed does liberate the New Woman, but its commodification means that a new hierarchy is now in place to differentiate those who are rich and fast from those who are poor and slow. This chapter reads cycling romance, a short-lived, ad-supported literary genre, to examine how the cycling New Woman is glamorized. It then analyses Wells’s The Wheels of Chance and Gissing’s stories to expose the hidden class exclusions behind the New Woman cyclist’s touted progressiveness.
Its Beauty, Danger, and Feverish Thrill
Authors: Chen Eva 
Published: November 2024

Abstract
Speed disciplines and commodifies the New Woman, but speed’s prosthetic extension of human faculties also rejuvenates the New Woman, compensates for these constraints, and fuels a thrilling fantasy of power and transcendence. The New Woman cyclist’s excitement at mastering the adrenaline-packed power of speed and forging a new speed-expanded self is palpable in Allen’s Miss Cayley’s Adventures, Mrs. Edward Kennard’s The Golf Lunatic and His Cycling Wife, and Gissing’s “The Schoolmaster’s Vision.” As women enter speed culture as new players, a new sexual energy is further unleashed that eroticizes speed, an active, aggressive, speed-liberated sexual energy that is traditionally linked with men but is now available to women.
Bladder Symptoms Provoked by Short, Rapid-Acting Loop Diuretics: A Frequent but Often Overlooked Problem
Authors: Wilcox Christopher S , Pourafshar Negiin , Han Karina , Shah Suzanne , Sussman Rachael D , Testani Jeffrey , Packer Milton , Rossignol Patrick , Zannad Faiez , Pitt Bertram , Shah Salim 
Published: November 2024

Abstract

BACKGROUND
Bladder dysfunction entails overactive bladder (OAB) defined as symptoms of urinary urgency, frequency, and/or nocturia with or without incontinence if there is no obvious pathology or infection or lower urinary tract symptoms that includes recognized causes of bladder dysfunction.

METHODS
Literature search.

RESULTS
Symptoms of OAB are reported in about 15% of the adult US population. This is increased 2- to 3-fold in patients with congestive heart failure (CHF), hypertension, cardiovascular disease (CVD), chronic kidney disease (CKD), or the elderly where it often accompanies prescription for short, rapid-acting loop diuretics. However, less than 2% of patients seeking care for OAB receive treatment. The fear of urinary incontinence from short, rapid-acting loop diuretics may contribute to medication nonadherence and less well-controlled, apparently resistant hypertension. The bladder contracts to rapid stretch. Thus, less rapid-acting diuretics such as thiazides or extended-release formulations of loop diuretics may be preferable for those with bladder dysfunction. Alternatively, the use of a mineralocorticosteroid receptor antagonist, angiotensin receptor antagonist/neprilysin inhibitor, or sodium glucose-linked transport type 2 inhibitor may allow a reduction in the dose of a short, rapid-acting loop diuretic for those with bladder dysfunction.

CONCLUSIONS
A worsening of symptoms from bladder dysfunction by short, rapid-acting loop diuretics occurs frequently in patients with CVD, CHF, hypertension, and CKD where it can contribute to impaired quality of life and poor adherence and thereby to worsening outcomes.
Habitat alters biogeographical and evolutionary patterns of body size in freshwater crayfishes
Authors: Graham Zackary A , Richardson Alastair M M 
Published: November 2024

Abstract
Biogeographical patterns explain variation in body size, although the strength and directions of these patterns vary. When researchers account for the micro- or macrohabitats that species inhabit, they often find that biogeographical relationships with body size are modified, especially in taxa that inhabit diverse environments. Freshwater crayfishes are an ideal group in which to study the interaction between habitat, biogeography, and body size, because there are &gt;700 crayfishes that inhabit aquatic environments, semi-terrestrial burrows, and caves. Here, we explore evolution of body size across 452 species of crayfish by considering the interaction between their habitats (aquatic, semi-terrestrial/aquatic, semi-terrestrial, and cave-dwelling) and the mean temperature of their geographical range. We documented 64-fold variation in body length. Aquatic species were the largest and had the greatest variation in body size. Crayfishes that inhabit both semi-terrestrial and aquatic habitats exhibit a weak negative relationship between body size and environmental temperature; solely aquatic species reverse this relationship. Evolutionarily, our ancestral reconstruction suggests that the ancestral crayfish was an aquatic species with a body length of 81.1 mm, which aligns with data from fossil crayfish. Overall, our study highlights how uniting biogeographical and evolutionary approaches improves our ability to explore patterns of animal body size and unearth explanatory mechanisms.
The Parkinson's disease DJ-1/PARK7 gene controls peripheral neuronal excitability and painful neuropathy
Authors: Lee Sang Hoon , Tonello Raquel , Lee Kihwan , Roh Jueun , Prudente Arthur Silveira , Kim Yong Ho , Park Chul-Kyu , Berta Temugin 
Published: November 2024

Abstract
Parkinson's disease is a progressive neurodegenerative disease with well-documented motor symptoms as well as less recognised, but significant, non-motor symptoms. These non-motor symptoms include prodromal pain and peripheral neuropathy, the causes of which are unknown.
We investigated the role of DJ-1/PARK7, a Parkinson's disease-associated gene, in prodromal pain and peripheral neuropathy. Using DJ-1 deficient mice, we conducted comprehensive sensory tests, cutaneous staining, molecular analyses and electrophysiological studies on mouse and human primary sensory neurons from dorsal root ganglia.
We found that these mice exhibited cold hypersensitivity, oxidative stress, and neuropathy of the cutaneous fibres of primary sensory neurones before any motor impairments were observed. Mechanistically, DJ-1 in primary sensory neurones regulated this hypersensitivity and neuropathy via TRPA1 signalling. Interestingly, we discovered that DJ-1 also plays a role in the progression of chemotherapy-induced peripheral neuropathies. Pain and mechanisms associated with these neuropathies were exacerbated in DJ-1 deficient mice but were significantly reduced by the pharmacological activation of DJ-1. Importantly, we also confirmed the expression of DJ-1 and its therapeutic potential in human primary sensory neurons.
Thus, we uncover a peripheral mechanism of DJ-1 and propose that it may serve as a new target for developing therapeutic approaches for Parkinson's disease-linked and other painful neuropathies.
Preparation of conductive bimetallic phthalocyanine with acceptor and their electrocatalytic properties for CO2 reduction
Authors: Takase Satoko , Aritsu Taku , Kamikawa Yuki , Takizawa Toshiyuki , Shimizu Youichi 
Published: November 2024

Abstract
In order to develop a catalyst for electrochemical CO2 reduction with high power efficiency, we prepared molecular crystals with 2 types of metal phthalocyanine. Charge transfer complexes with acceptor were selected as the molecular crystal system to reduce the electrical resistance. Various bimetallic phthalocyanine systems consisting of cobalt phthalocyanine and another metal phthalocyanine were obtained as highly conductive separated stacked charge transfer complexes with iodine as an acceptor. The obtained catalysts for CO2 reduction were evaluated using gas diffusion electrodes. The catalysts containing the bimetallic phthalocyanine system of cobalt and copper phthalocyanines showed higher CO2 reduction current and higher CO production, indicating that the CO2 reduction on cobalt phthalocyanine is enhanced by the H2 formation reaction on copper phthalocyanine.
Technology rhetoric and institutional ownership
Authors: Andreou Panayiotis C , Drivas Kyriakos , Philip Dennis , Wood Geoffrey 
Published: November 2024

Abstract
This article compares actual R&D spend with the managerial rhetoric around technology and innovation contained within corporate disclosures of US-listed firms. We find that, whilst actual R&D spend and patents do not entice institutional investors to increase their stock holdings, firms that espouse technology and innovation in their corporate disclosures are quite successful in drawing in short-term investors. We frame this investor behaviour within the economics of expectation literature. While managers are incentivised to draw in capital, short-horizon investors are less likely to exert due diligence and are rather persuaded by a technology narrative—that is, a ‘gold rush’ effect. This explains our finding that when there is a sudden downturn with stock price crashes, short-term investors rush to withdraw their money from firms that ‘talk tech’. Our findings have implications for managerial rewards systems, especially when these encourage managerial hype.
Ascending aortic length predicts adverse outcomes in type A intramural haematoma
Authors: Chen Zerui , Wu Jinlin , Liu Jie , Song Jiayu , Qiu Hailong , Zhuang Jian 
Published: November 2024

Abstract

OBJECTIVES
Ascending aortic length has recently been recognized as a novel predictor of adverse events in aortic diseases, but its prognostic value in type A intramural haematoma is unknown. We aimed to evaluate the association between ascending aortic length and outcomes in patients with type A intramural haematoma initially managed medically.

METHODS
We retrospectively analysed patients with acute type A intramural haematoma. Ascending aortic length was measured by computed tomography. The primary outcome was aortic progression, defined as aortic intervention or aortic-related death.

RESULTS
A total of 98 patients were enrolled. During a median follow-up of 2.6 years, aortic progression occurred in 27 patients (27.6%), i.e. 9 events per 100 patient-years. Patients with ascending aortic length ≥11 cm had significantly higher rates of aortic progression [54.2% (20.9 events per 100 patient-years) vs 18.9% (6.1 events per 100 patient-years), P = 0.001], surgical intervention (45.8% vs 12.2%, P = 0.001) and presence of ulcer-like projection (25.0% vs 2.7%, P = 0.002) compared to those with ascending aortic length &lt;11 cm. Kaplan–Meier analysis demonstrated lower progression-free survival in the ascending aortic length ≥11 cm group (P = 0.0021). Ascending aortic length had a sensitivity of 61.9% and specificity of 77.8% for predicting aortic progression, with an area under the curve of 0.756 (95% confidence interval 0.649–0.862).

CONCLUSIONS
Ascending aortic elongation may identify a high-risk subgroup of acute type A intramural haematoma patients initially managed medically who could potentially benefit from early surgery. Ascending aortic length should be considered in the risk stratification and management of these patients.
Sperm as a speciation phenotype in promiscuous songbirds
Authors: Lifjeld Jan T , Cramer Emily R A , Leder Erica H , Voje Kjetil Lysne 
Published: November 2024

Abstract
Sperm morphology varies considerably among species. Sperm traits may contribute to speciation if they diverge fast in allopatry and cause conspecific sperm precedence upon secondary contact. However, their role in driving prezygotic isolation has been poorly investigated. Here we test the hypothesis that, early in the speciation process, female promiscuity promotes a reduction in overlap in sperm length distributions among songbird populations. We assembled a data set of 20 pairs of populations with known sperm length distributions, a published estimate of divergence time, and an index of female promiscuity derived from extrapair paternity rates or relative testis size. We found that sperm length distributions diverged more rapidly in more promiscuous species. Faster divergence between sperm length distributions was caused by the lower variance in the trait in more promiscuous species, and not by faster divergence of the mean sperm lengths. The reduced variance is presumably due to stronger stabilizing selection on sperm length mediated by sperm competition. If divergent sperm length optima in allopatry causes conspecific sperm precedence in sympatry, which remains to be shown empirically, female promiscuity may promote prezygotic isolation, and rapid speciation in songbirds.
Dominant myosin storage myopathy mutations disrupt striated muscles in Drosophila and the myosin tail–tail interactome of human cardiac thick filaments
Authors: Viswanathan Meera C , Dutta Debabrata , Kronert William A , Chitre Kripa , Padrón Raúl , Craig Roger , Bernstein Sanford I , Cammarato Anthony 
Published: November 2024

Abstract
Myosin storage myopathy (MSM) is a rare skeletal muscle disorder caused by mutations in the slow muscle/β-cardiac myosin heavy chain (MHC) gene. MSM missense mutations frequently disrupt the tail's stabilizing heptad repeat motif. Disease hallmarks include subsarcolemmal hyaline-like β-MHC aggregates, muscle weakness, and, occasionally, cardiomyopathy. We generated transgenic, heterozygous Drosophila to examine the dominant physiological and structural effects of the L1793P, R1845W, and E1883K MHC MSM mutations on diverse muscles. The MHC variants reduced lifespan and flight and jump abilities. Moreover, confocal and electron microscopy revealed that they provoked indirect flight muscle breaks and myofibrillar disarray/degeneration with filamentous inclusions. Incorporation of GFP-myosin enabled in situ determination of thick filament lengths, which were significantly reduced in all mutants. Semiautomated heartbeat analysis uncovered aberrant cardiac function, which worsened with age. Thus, our fly models phenocopied traits observed among MSM patients. We additionally mapped the mutations onto a recently determined, 6 Å resolution, cryo-EM structure of the human cardiac thick filament. The R1845W mutation replaces a basic arginine with a polar-neutral, bulkier tryptophan, while E1883K reverses charge at critical filament loci. Both would be expected to disrupt the core and the outer shell of the backbone structure. Replacing L1793 with a proline, a potent breaker of α-helices, could disturb the coiled-coil of the myosin rod and alter the tail–tail interactome. Hence, all mutations likely destabilize and weaken the filament backbone. This may trigger disease in humans, while potentially analogous perturbations are likely to yield the observed thick filament and muscle disruption in our fly models.
Leveraging a new data resource to define the response of Cryptococcus neoformans to environmental signals
Authors: Kang Yu Sung , Jung Jeffery , Brown Holly L , Mateusiak Chase , Doering Tamara L , Brent Michael R 
Published: November 2024

Abstract
Cryptococcus neoformans is an opportunistic fungal pathogen with a polysaccharide capsule that becomes greatly enlarged in the mammalian host and during in vitro growth under host-like conditions. To understand how individual environmental signals affect capsule size and gene expression, we grew cells in all combinations of 5 signals implicated in capsule size and systematically measured cell and capsule sizes. We also sampled these cultures over time and performed RNA-seq in quadruplicate, yielding 881 RNA-seq samples. Analysis of the resulting data sets showed that capsule induction in tissue culture medium, typically used to represent host-like conditions, requires the presence of either CO2 or exogenous cyclic AMP. Surprisingly, adding either of these pushes overall gene expression in the opposite direction from tissue culture media alone, even though both are required for capsule development. Another unexpected finding was that rich medium blocks capsule growth completely. Statistical analysis further revealed many genes whose expression is associated with capsule thickness; deletion of one of these significantly reduced capsule size. Beyond illuminating capsule induction, our massive, uniformly collected data set will be a significant resource for the research community.
The constitutional impact of rule-of-law spending conditionality
Authors: Torres Pérez Aida 
Published: November 2024

Abstract
The negotiation of an unprecedented recovery package to address the consequences of the COVID-19 pandemic provided momentum for a new instrument to condition the disbursement of EU funds to compliance with the rule-of-law principles. Regulation 2020/2092 (“the Conditionality Regulation”) was aimed at protecting the financial interests of the European Union and the sound management of EU funds against breaches of the rule of law. The aim of this article is to assess the validity, effectiveness, and broader impact of rule-of-law conditionality upon the EU constitutional architecture. The effectiveness in practice of the Conditionality Regulation is evaluated, together with the role of other conditionality mechanisms that have been used to promote rule-of-law standards, mainly the Recovery and Resilience Facility, which is the centerpiece of the NextGenerationEU package, and the Common Provisions Regulation, which includes a horizontal enabling condition that makes EU funds contingent upon the effective implementation and application of the EU Charter of Fundamental Rights. The suitability of rule-of-law conditionality as a form of governance with the current EU constitutional architecture is critically examined. Conditioning funding to promote values raises concerns from a constitutional perspective that include the risk of competence creep, repercussions for citizenship, and, finally, the undermining of trust and solidarity in interactions among member states. The Conditionality Regulation represents a relevant addition to the toolbox of instruments devised to address rule-of-law backsliding in the European Union, yet the expansion of rule-of-law conditionality could also be consequential for the ethos of the European Union.
Setting priorities for police operations by using a multicriteria decision approach with partial information
Authors: da Cunha Carla Patrícia Cintra Barros , de Miranda Mota Caroline Maria , Frej Eduarda Asfora , Roselli Lucia Reis Peixoto , de Almeida Adiel Teixeira 
Published: November 2024

Abstract
Accepted by: Konstantinos Nikolopoulos
The paper presents a real-world decision-making problem in the context of the Brazilian Federal Police (BFP), which consists of establishing priorities for police operations. This study deals with allocating resources to trigger police operations that, while demanding more resources and specialized techniques, also promote the effectiveness of police actions more conspicuously and directly. Driven by the value-focused thinking methodology, the objectives and values of the Federal Police were structured and represented by criteria, which let police operations be evaluated and prioritized. The Flexible and Interactive Tradeoff method was applied to rank the operations, with an innovative methodological perspective, which integrates two different paradigms for preference modelling: elicitation by decomposition and holistic evaluations. A mathematical modelling approach is presented to deal with the combination of both types of information obtained by the decision-maker (DM), in order to search for dominance relations between alternatives. This study shows how incorporating holistic judgements in the process can be useful for tightening the decision process since the inequalities obtained with holistic judgements have a high impact on the space of weights compatible with the DM’s preferences. A clear conceptual framework is presented for the analysis, showing how the application of such a combined approach to prioritizing special police operations adds a step to the decision-making processes and policies of the BFP, thereby broadening the managerial implications of tackling public security issues by seeking to solve them using management mathematics.