bluuebunny/crossref_metadata_2025_split huggingface dataset:
(014) RATES OF INFLATABLE PENILE PROSTHESIS INFECTION WITH INTRAOPERATIVE 0.05% CHLORHEXIDINE GLUCONATE ANTIBIOTIC IRRIGATION COMPARED TO TRADITIONAL ANTIBIOTIC IRRIGATION
Authors: A Pereira T , Good J , Egemba C , O Rust J , Bajic P , L Bernie H 
Published: December 2024

Abstract

Introduction
Primary inflatable penile prosthesis (IPP) surgery carries a 1-3% reported infection rate, but the necessary revision/explant rises to a 10% risk of infection. Intraoperative antibiotic irrigation is employed throughout surgery for this reason. 0.05% Chlorhexidine Glucoronate solution (Irrisept) is an antibacterial, antifungal, and antiviral alternative to traditional antimicrobials.

Objective
In this study we aim to assess the efficacy of intraoperative Irrisept irrigation in preventing post-operative infection in comparison to vancomycin, gentamicin, fluconazole and bacitracin.

Methods
This was a retrospective review of all patients undergoing primary IPP placement or revision, from January 2019-September 2023, at a single institution. Patient demographics, comorbidities, surgery type, operative time, prosthesis type, and 90-day post-operative complications were reviewed. Chi-square analysis was performed to determine statistically significant (p &lt; 0.05) differences in postoperative infections among various groups.

Results
415 men were included in this study, 27% received Irrisept, 31% received bacitracin, 20% received vancomycin + gentamicin, and 23% received some other antibiotic irrigation combination. We found no significant difference in the infection rate between Irrisept and non-Irrisept irrigation (p = 0.523). There was no significant difference in post-operative infections when comparing Irrisept and vancomycin + gentamicin (p = 0.756), bacitracin (p = 0.785), and other combinations (p = 0.304). Additionally, there was no significant difference in infection rates between different prosthesis types. (p = 0.568).

Conclusions
The use of intraoperative Irrisept for antibiotic irrigation is effective in preventing post-operative infections in men undergoing IPP surgery. Irrisept is comparable and at least equally effective to conventional antibiotic irrigation.

Disclosure
Any of the authors act as a consultant, employee or shareholder of an industry for: Boston Scientific, Coloplast and BK Ultrasound.
(016) ENHANCING SEXUAL AND MENTAL HEALTH THROUGH TANTRA MINDFULNESS THERAPY (TMT®): NEUROPHYSIOLOGICAL INSIGHTS FROM QEEG MEASUREMENTS
Authors: Gentry M 
Published: December 2024

Abstract

Introduction
Emerging psychotherapeutic treatments have increasingly recognized the importance of mindfulness practices in mental and sexual health. Tantra Mindfulness Therapy (TMT®), a synthesis of ancient meditative techniques with modern psychological practices, promises significant health benefits by influencing brain activity. Prior research indicates that mindfulness can profoundly affect emotional well-being and interpersonal dynamics through modifications in neural oscillations.

Objective
The purpose of this study is to explore the impact of TMT® on specific brain wave frequencies-including Gamma waves, associated with cognitive functions like altruism and love-and to examine its effects on psychological states among participants. In addition to how it would affect their sex lives.

Methods
Participants enrolled in a series of TMT® sessions were monitored using quantitative electroencephalogram (QEEG) tools, including the Muse and Mind Monitor systems, which tracked changes in Alpha, Theta, Delta, Beta, and Gamma wave activity. Psychological health was assessed before and after the therapy sessions using a Likert scale (0-10) to evaluate levels of anxiety, depression, and stress.

Results
Post-TMT®, there was a significant elevation in Gamma wave activity, correlating with improved emotional processing and empathy. Concurrently, Beta waves showed dual behavior with initial decreases followed by increases, suggesting enhanced focus and concentration. Alpha waves, typically associated with relaxation, and Theta waves, linked to deep meditation, also saw increases. These changes were accompanied by statistically significant reductions in anxiety and stress (p &lt; 0.05), with notable decreases in depression symptoms reported by participants. Additionally, enhanced feelings of relaxation and euphoria were consistently documented, highlighting the therapy’s positive psychological impact. In addition participants experience less sexual anxiety and erectile dysfunction.

Conclusions
Tantra Mindfulness Therapy (TMT®) effectively induces neurophysiological changes that align with better emotional and mental health outcomes. The complex modulation of Beta, Alpha, and Theta wave activities underlines the therapy’s capacity to enhance focus, relaxation, and meditative depth, thereby making it a valuable psychotherapeutic tool for enhancing sexual and mental wellness. These findings support the integration of TMT® into broader psychotherapeutic practices, offering a new avenue for treating sexual and psychological health issues.

Disclosure
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(024) EFFECT OF DAILY PHOSPHODIESTERASE 5 INHIBITOR USE ON TRIMIX INTRACORPOREAL INJECTION DOSAGE IN MEN WITH SEXUAL DYSFUNCTION FOLLOWING RADICAL PROSTATECTOMY
Authors: Khalaf Alla K , Mahdi M , Majzoub A , Jacob J , Slovacek H , Wang R 
Published: December 2024

Abstract

Introduction
Trimix intracavernosal injections (ICI) is believed to be a reliable treatment option for men who underwent radical prostatectomy resulting in satisfactory erections suitable for penetration. Nonetheless, higher doses of trimix ICI may illicit penile pain and are associated with a higher incidence of priapism.

Objective
The aim of this study was to explore whether daily PDE5i use may potentiate the effect of ICI allowing patients to achieve the desired response with lower Trimix ICI dosage.

Methods
We conducted a retrospective analysis of our institutional database to identify patients experiencing erectile dysfunction due to prostate cancer treatment. Data about 155 Patients who underwent Ultrasound Penile Doppler (US PD), utilized Trimix ICI with/without daily PDE5i between 2020 & 2022, and had a follow-up for at least 1 year were included. Correlations were made between demographic data, ultrasound penile doppler readings, and changes in Trimix ICI dosage. Patients were divided into 2 groups based on their PDE5i usage (group 1: No PDE5i intake n = 84; group 2: PDE5i intake n = 71) and chi-squared test was used to explore the effect of PDE5i on changes in ICI dosage.

Results
Overall, 20.6% of the patients had diabetes, 52.3% had hypertension, 76.2% had prostatectomy, 29% had a previous history of radiation treatment, 18.7% had a history of androgen deprivation therapy, and 18.1% reported using B blockers. Additionally, 57% of the patients utilized vacuum erection devices. No significant correlation was observed between changes in ICI dosage and the parameters listed in Table 1. Significantly higher percentage of patients from group 1 reported an increase in Trimix ICI dose during follow-up compared with group 2 (59.1% vs 40.9%, p = 0.04). None of the 155 patients experienced priapism during the follow-up period.

Conclusions
While additional comprehensive follow-up is required, these preliminary results suggest that consistent daily use of PDE5i is not only safe but also has the potential to diminish the requirement for increased doses of Trimix ICI within this specific group of patients.

Disclosure
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(031) “INNOVATIVE STRATEGIES FOR ERECTILE DYSFUNCTION: STRATIFY AND DIAGNOSE TO REGENERATE AND RESTORE”
Authors: Rajiwate FL , Ss DV 
Published: December 2024

Abstract

Introduction
Current treatments for erectile dysfunction (ED) prioritize symptom management over addressing root causes, often failing to provide a cure. Transitioning to an “intent to cure” strategy is crucial, focusing on cellular and molecular mechanisms of erection and stabilizing erection homeostasis. A systematic approach to diagnosis and therapy, grounded in understanding erection physiology, is vital for developing effective regenerative and restorative ED therapies. Validating research findings on erection physiology’s intricate mechanisms enables tailored therapeutic strategies targeting specific etiological factors. This abstract underscores the urgent need for regenerative and restorative ED therapies, revolutionizing management and enhancing patient outcomes.

Objective
1. To assess the Vascular Reactive Index (VRI) and Augmentation Index (ALX) in Vasculogenic erectile dysfunction (VED) patients. 2. To correlate the results with the clinical condition to assess the diagnostic sensitivity. 3. Categorization of VED based on VRI and ALX value.

Methods
Conducted at Ankur Health Care, Bangalore, India from September 2021 to January 2023, this prospective study included 199 patients (n = 199). Among them, 115 had no comorbidities, while 44 had comorbidities. Patients diagnosed with vasculogenic erectile dysfunction (VED) via standard penile Doppler criteria, regardless of age, were included. Exclusion criteria comprised 40 patients with psychogenic ED. Vascular Reactive Index (VRI) and Augmentation Index (ALX) were measured using Vendys 5000 and SphygmoCor® XCEL, respectively, adhering to standardized techniques.

Results
In vasculogenic erectile dysfunction (VED), prevalence peaks among individuals aged 31 to 40 years. Regarding IIEF scores, 40.7% showed mild to moderate, 30% moderate, 29% severe, and 5.3% mild scores. EHS grades were predominantly grade 2 (67%), followed by grades 1, 3, and 0. VRI analysis revealed poor diagnostic sensitivity (47.7%), while ALX exhibited good sensitivity (92.9%). Penile Doppler had 85% sensitivity, VRI 47%, ALX 92%, and PWV 17.60%. These findings underscore the importance of comprehensive diagnostic approaches in managing VED.

Conclusions
Our study reveals the diagnostic sensitivity of vascular parameters in Vasculogenic Erectile Dysfunction (VED). ALX emerges as the most sensitive marker, followed by Penile Doppler and VRI. Arterial stiffness prevails over endothelial dysfunction in VED, albeit less severe. These findings underscore the complexity of vascular factors in VED and highlight the need for comprehensive assessment. Advancements in sexual physiology research are crucial for developing restorative therapies aiming to cure ED. Future research should focus on unraveling the cellular and molecular mechanisms underlying erection homeostasis to improve treatment outcomes.

Disclosure
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(039) ERECTION DURATION AND FIRMNESS: A DESCRIPTIVE ANALYSIS FROM A POPULATION-BASED STUDY
Authors: Saffati G , Orozco Rendon D , Daily R , Khera M , Justin E 
Published: December 2024

Abstract

Introduction
Erectile function is a critical aspect of male sexual health, governed by complex physiological mechanisms, and its evaluation is essential for diagnosing erectile dysfunction and understanding broader sexual health issues. While traditional assessment methods like self-reports and laboratory techniques have limitations, the advent of wearable penile ring devices enables continuous, real-world monitoring of erections with unprecedented objectivity.

Objective
This study synthesizes data from the FirmTech penile ring to provide insights into average erection characteristics and enhance our understanding of erectile function and its implications for overall well-being.

Methods
This study retrospectively collected data from all patients who used the FirmTech TechRing, a device designed to monitor erectile data, between August 14, 2023 and February 14, 2024. The collected data were de-identified and anonymized in accordance with FirmTech’s privacy policy, ensuring user confidentiality. FirmTech’s proprietary algorithm processes the recorded penile activity data to detect erections and generate graphical representations, which are reported through the accompanying application.

Results
The dataset comprised 2446 recorded observations from 795 participants, with a mean age of 50 years (SD = 13.46) and a mean BMI of 27.03 kg/m2 (SD: 5.14). Diabetes prevalence stood at 10.7%, with 11.4% of all patients being current smokers. For recordings less than 1 hour (n = 218), the median recording duration was 25.2 minutes, during which 276 erection events were documented, with a median duration of 12.1 minutes and a firmness rating of 8.6/10. In contrast, for recordings exceeding 1 hour (n = 2228), the median recording duration was 7.25 hours, with 5599 erection events identified. These lengthier recordings featured a median erection duration of 30.5 minutes, a median of 2 erections per recording, and a median firmness of 7.25/10. Histograms depicting erection durations for recordings lasting less than 1 hour and those exceeding 1 hour are illustrated in figs. 1A and 1B, respectively.

Conclusions
This study provides an unprecedented, objective look at male erection characteristics in real-world settings through wearable technology, paving the way for deeper insights into sexual health and function as well as improved strategies for addressing erectile dysfunction and other related concerns.

Disclosure
Any of the authors act as a consultant, employee or shareholder of an industry for: FirmTech.
(046) SEXUAL HEALTH AMONG WOMEN WITH POLYCYSTIC OVARIAN SYNDROME
Authors: Gharbi I , Kaabia O , Smaali MH , Guefrech O , Bahri YM 
Published: December 2024

Abstract

Introduction
Polycystic ovary syndrome (PCOS) is a common hormonal disorder in young women. It is associated with several physical changes such as excessive facial hair, acne, and obesity. PCOS can lead to hormonal imbalances that may affect sexual health.

Objective
This study aims to explore the association between PCOS and female sexual function.

Methods
We conducted a nested case–control study where the cases were self-reported PCOS patients and controls were self-reported healthy women matching for medical history, age, and relationship status. Data was collected through an online self-administered questionnaire. The sexual function was assessed through validated translations of the Female Sexual Function Index (Female sexual dysfunction is defined by an FSFI score ≤ 26.55).

Results
In this study, we included 42 females with PCOS who were compared to 84 controls. Age and other main socio-demographic components were similar between groups. The prevalence of female sexual dysfunction among PCOS patients was 40.5% compared to 47.6% in the controls. (p = 0.44). There was no statistical difference between both groups in terms of total FSFI score (p = 0.43). There was also no difference between the groups among the six FSFI domains’ scores (Desire, Orgasm, Excitation, Lubrication, Pain, and Satisfaction).

Conclusions
This case–control study shows no difference in terms of sexual function between PCOS patients and healthy young women. Although the literature may claim that PCOS might be associated with an altered sexual health, our population was under treatment at the time of study and PCOS hormonal treatment may have interacted with patients’ sexuality.

Disclosure
No.
(050) EFFECT OF VAGINAL ESTRIOL ON MOOD DISORDER SYMPTOMS IN POSTMENOPAUSAL WOMEN WITH DYSPAREUNIA: A RANDOMIZED CLINICAL TRIAL
Authors: De Paula SR , Sanches Carneiro P , Henrique Pires Okano S , Mendes MC , Alves Da Silva L 
Published: December 2024

Abstract

Introduction
The climateric is a period of notable physical and social changes, often accompanied by emotional problems, especially in women experiencing symptoms of the genitourinary syndrome of menopause (GSM), notably dyspareunia. There is orrelation between dyspareunia and depression, adversely affecting the quality of life during this period. While acknowledging its complexity and multifaceted nature, it is understood that a substantial aspect of the pathophysiology of depression in menopausal and postmenopausal women is sustained by hypoestrogenism. The estriol is the primary estrogen specifically targeting issues associated with estrogen deficiency, including dyspareunia.

Objective
To investigate the relationship between the risk of anxiety and depression in women with dyspareunia undergoing estriol treatment on proximal and distal vaginal wall.

Methods
this is a randomized controlled trial. A total of 176 postmenopausal women aged 40 to 65 years, diagnosed with dyspareunia, were randomly allocated into three groups: proximal estriol group (PEG), distal estriol group (DEG), and a vaginal water-based lubricating gel group during sexual intercourse (GL). The treatment duration spanned 12 weeks, with follow-up assessments conducted accordingly. Main Outcome Measures: The HADS instrument was utilized to evaluate mood disorder symptoms.

Results
The sample was homogeneous among the groups concerning baseline data (Age, BMI, FSH, Glucose, TSH, and estriol). Serum estriol levels after treatment did not significantly increase and remained within normal parameters. When comparing the baseline assessment to three months after intervention, a notable decrease in the scores of the Hospital Anxiety and Depression Scale (HAD) was observed in both the PEG group (15.95 ± 7.61 to 6.53 ± 3.4, p &lt; 0.01) and the distal estriol groups (15.46 ± 8.11 to 6.68 ± 4.71, p &lt; 0.01), while there was a non-significant decrease in the GL group (15.67 ± 6.26 to 7.26 ± 4.01, p = 0.08). For the anxiety domain, all treatments were effective in reducing scores (PEG: 8.47 ± 4.64-5.62 ± 3.35, p &lt; 0.01; DEG: 8.35 ± 4.83-5.31 ± 3.61, p &lt; 0.01; LG: 8.14 ± 3.89-7.01 ± 4.17, p = 0.04). In the depression domain, a significant reduction was observed for the estriol-treated groups (PEG: 7.47 ± 3.91-12.24 ± 6.18, p &lt; 0.01; DEG: 7.11 ± 3.79-11.97 ± 7.77, p &lt; 0.01; LG: 7.52 ± 3.19-14.36 ± 7.35, p = 0.34). In the comparison between groups, PEG and DEG interventions were superior to the GL.

Conclusions
All treatments resulted in reductions in mood disorder scores. However, estriol treatments exhibited superiority in improving the HADS scores for anxiety and depression compared to GL. Despite this, there was no significant increase in serum estriol levels. Therefore, it can be inferred that the treatment of dyspareunia may have positively influenced the mood of these women.

Disclosure
No.
(109) PROFESSIONAL QUALIFICATION OF CONTENT CREATORS IN PENILE AESTHETIC PROCEDURES ON SOCIAL MEDIA PLATFORMS IN BRAZIL
Authors: Messina L , Fregonesi A , Messina C 
Published: December 2024

Abstract

Introduction
Social networks have become a source of information on various topics, including genital aesthetics. But these data are not always reliable, as the authors are not necessarily trained in these procedures.

Objective
This study aims to assess the professional qualifications of individuals disseminating penile aesthetic techniques on popular social media platforms in Brazil, analyzing the credibility of the information shared in relation to the professional status of the content creators.

Methods
A comprehensive internet search was conducted across YouTube, Facebook, and TikTok using keywords such as “male genital aesthetics,” “penile thickening,” “penile enlargement,” “penile bioplasty,” and “penile harmonization.” The first 30 results for each keyword on each platform were analyzed to classify the content creators into medically qualified professionals (doctors) and non-medical professionals, further subdividing the latter based on their disclosed qualifications.

Results
TikTok displayed the highest number of views at 3121889 but had the lowest proportion of medical professionals (30%) sharing content on penile aesthetics. YouTube had 830 873 views with a higher presence of medical professionals (27 doctors versus 3 non-doctors). Facebook, while having the least views (24000), maintained a high ratio of medical professionals (28 doctors versus 2 non-doctors).

Conclusions
The findings indicate a significant public interest in penile aesthetic procedures in Brazil, with social media being a primary source of information. While a majority of the content is produced by medical professionals, the platform with the highest engagement, TikTok, shows a concerning trend with only 30% of the content creators being medically qualified. This disparity highlights the need for enhanced regulation and public education to ensure the credibility and safety of information regarding penile aesthetic procedures.

Disclosure
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(123) OUTCOMES OF VAGINOPLASTY IN PATIENTS WITH DISORDERS OF SEX DEVELOPMENT
Authors: Monteiro Filho M , Bruno Z , Nacle L , Ciriaco M , Bruno P 
Published: December 2024

Abstract

Introduction
The use of autologous skin grafts through the McIndoe technique for neovagina construction is the most common approach for patients with vaginal malformation, atresia, or agenesis. However, this technique leaves a scar at the donor site with potential for infection and dehiscence. A novel technique developed in Ceará, using Nile tilapia skin, has been performed since 2016 with great results.

Objective
To describe the main etiologies, epidemiological data, and gynecological examination findings of a group of patients with differences in sex development (DSD) who underwent neovaginoplasty at a tertiary university hospital.

Methods
This is a retrospective, cross-sectional, and quantitative study through the review of medical records of patients who underwent neovaginoplasty from April 2004 to April 2024. The collected data were organized in a spreadsheet and presented as mean, number, and percentages.

Results
Records of 62 patients were obtained during this time period, of which 74% were diagnosed with Mayer-Rokitansky-Küster-Hauser syndrome; 17% with 46,XY DSD; 3% with other Müllerian anomalies; 1% with Fraser syndrome; 1% with the classical form of congenital adrenal hyperplasia; and 1% with ovotesticular DSD with 46,XX karyotype. The average age at diagnosis was 17.9 years and the average age at surgery was 20.8 years. Regarding the technique used, 68% underwent neovaginoplasty with Nile tilapia skin, 29% with autologous skin, and 1% with the sigmoid colon, the latter performed at another hospital. During the first consultation, 82% had a vaginal canal length of less than two cm, with an average of 0.6 cm (two patients had attempted vaginal dilation with silicone molds prior to surgery, reaching a maximum of two cm). Out of all cases, 51 had information on vaginal length in postoperative follow-ups. Vaginal length was measured at the first, third, sixth month, and one year postoperatively, with an average of 8.2 cm. Four patients, who were not sexually active and did not use the silicone mold as instructed postoperatively, experienced a regression to less than four cm in vaginal length one year after surgery. Half of the patients reported satisfactory sexual activity with penetration; six complained of a short vagina and dyspareunia, while this information was not found in the records for the remaining patients.

Conclusions
Neovaginoplasty using Nile tilapia skin has proven to be an important tool for promoting the quality of life and sexual health of patients with DSD associated with vaginal atresia or agenesis.

Disclosure
No.