bluuebunny/crossref_metadata_2025_split huggingface dataset:
Serum haptoglobin and protein electrophoretic fraction modifications in buffaloes (Bubalus bubalis) around calving and during early lactation
Authors: Gianesella Matteo , Fiore Enrico , Arfuso Francesca , Vecchio Domenico , Curone Giulio , Morgante Massimo , Mazzotta Elisa , Badon Tamara , Rossi Pasquale , Bedin Silvia , Zumbo Alessandro , Piccione Giuseppe 
Published: July 2019

AbstractSerum protein distribution and concentration can be affected by different physiological and pathological conditions. The aim of this study was to evaluate the changes in the concentration of serum protein fractions and haptoglobin in clinically healthy dairy buffaloes during late pregnancy and early lactation. Blood and milk samples were collected from 30 buffaloes at around 7 d before expected calving (blood only) and 7, 30 and 50 d after calving. In serum samples, the total protein, haptoglobin, albumin, α1-, α2-, β1-, β2-, γ-globulins, and albumin/globulin ratio (A/G) values were evaluated. In milk, fat%, protein%, lactose%, somatic cell score (SCS) were assessed, along with milk yield (MY) and daily milk production (DMP). The peripartum period significantly influenced (P < 0.005) total protein, albumin, haptoglobin, α2-, β2- and γ-globulins (P < 0.005). Milk yield, DMP and fat% changed significantly throughout the monitoring period (P < 0.005). Milk yield and DMP were positively correlated with total protein, albumin, β2-globulins and A/G ratio, and negatively correlated with haptoglobin and α2-globulins. These results provide new knowledge about the serum protein electrophoretic pattern in Italian Mediterranean Buffaloes during the last phase of pregnancy and early stages of lactation.
Optimizing the electron acceleration in vacuum by chirped ultrashort laser pulse using particle swarm method
Authors: Rezaei-Pandari Mohammad , Jahangiri Fazel , Niknam Ali Reza 
Published: July 2019

AbstractEfficient electron acceleration by a linearly chirped ultrashort laser pulse in vacuum is investigated using the particle swarm optimization method. By applying this method for optimizing the initial parameters of the laser pulse, a pronounced increase in final energy gain of the electron is obtained compared to that expected from the successive optimization method. Our results also suggest that the value of the optimal chirp parameter is independent of laser polarization and the energy gain could be insensitive to the sign of this parameter when the initial phase is optimally adjusted. In addition, utilizing the chirped laser pulse with optimized conditions for acceleration of an electron bunch reveals that the energy spectrum is shifted to considerably higher energies and the spatial distribution is significantly improved in a polarization-dependent manner.
Extending the range of measurement of thermal imaging diagnostics of a high-intensity pulsed ion beam
Authors: Pushkarev A. , Zhu X. P. , Prima A. , Egorova Yu. , Lei M. K. 
Published: July 2019

AbstractThermal imaging diagnostics was used as a surface temperature mapping tool to characterize the energy density distribution of a high-intensity pulsed ion beam. This approach was tested on the TEMP-6 accelerator (200–250 kV, 150 ns). The beam composition included carbon ions (85%) and protons, and the energy density in the focus was 5–12 J/cm2. Targets of stainless steel, titanium, brass, copper, and tungsten were examined. Our observations show that the maximum energy density measured with the thermal imaging diagnostics considerably exceeds the ablation threshold of the targets. An analysis of the overheating mechanisms of each target was carried out, including metastable overheating of the target to above its boiling temperature during rapid heating; formation, migration, and the subsequent annealing of fast radiation-induced defects in the target under ion beam irradiation. This expands the range of energy density measurement for this thermal imaging diagnostics from 2–3 J/cm2 up to 10–12 J/cm2 but introduces error into the results of measurement. For a stainless steel target, this error exceeds 15% at an energy density of more than 4 J/cm2. A method of correcting the results of the thermal imaging diagnostics is developed for a pulsed ion beam under conditions of intense ablation of the target material.
Heated Humidified High-Flow Nasal Cannula for Preterm Infants: An Updated Systematic Review and Meta-analysis
Authors: Fleeman Nigel , Dundar Yenal , Shah Prakesh S , Shaw Ben NJ 
Published: July 2019

AbstractBackgroundHeated humidified high-flow nasal cannula (HHHFNC) is gaining popularity as a mode of respiratory support. We updated a systematic review and meta-analyses examining the efficacy and safety of HHHFNC compared with standard treatments for preterm infants. The primary outcome was the need for reintubation for preterm infants following mechanical ventilation (post-extubation analysis) or need for intubation for preterm infants not previously intubated (analysis of primary respiratory support)MethodsWe searched PubMed, MEDLINE, Embase, and the Cochrane Library for randomized controlled trials (RCTs) of HHHFNC versus standard treatments. Meta-analysis was conducted using Review Manager 5.3.ResultsThe post-extubation analysis included ten RCTs (n = 1,201), and the analysis of primary respiratory support included ten RCTs (n = 1,676). There were no statistically significant differences for outcomes measuring efficacy, including the primary outcome. There were statistically significant differences favoring HHHFNC versus nasal cannula positive airway pressure (NCPAP) for air leak (post-extubation, risk ratio [RR] 0.29, 95 percent confidence interval [CI] 0.11 to 0.76, I2 = 0) and nasal trauma (post-extubation: 0.35, 95 percent CI 0.27 to 0.46, I2 = 5 percent; primary respiratory support: RR 0.52, 95 percent CI 0.37 to 0.74; I2 = 27 percent). Studies, particularly those of primary respiratory support, included very few preterm infants with gestational age (GA) <28 weeks.ConclusionsHHHFNC may offer an efficacious and safe alternative to NCPAP for some infants but evidence is lacking for preterm infants with GA ≤28 weeks.
Context-Specific Economic Evaluation for Molecular Pathology Tests: An Application in Colorectal Cancer in the West of Scotland
Authors: Bouttell Janet , Tan Yun Yi , Creed David , McGaffin Gillian , Hawkins Neil , McLaughlin Ruth , Smith Graeme , Westwood Paul , Williams Nicola , Graham Janet 
Published: July 2019

AbstractObjectivesThe cost-effectiveness of molecular pathology testing is highly context dependent. The field is fast-moving, and national health technology assessment may not be relevant or timely for local decision makers. This study illustrates a method of context-specific economic evaluation that can be carried out in a limited timescale without extensive resources.MethodsWe established a multi-disciplinary group including an oncologist, pathologists and a health economist. We set out diagnostic and treatment pathways and costs using registry data, health technology assessments, guidelines, audit data, and estimates from the group. Sensitivity analysis varied input parameters across plausible ranges. The evaluation setting was the West of Scotland and UK NHS perspective was adopted. The evaluation was assessed against the AdHopHTA checklist for hospital-based health technology assessment.ResultsA context-specific economic evaluation could be carried out on a timely basis using limited resources. The evaluation met all relevant criteria in the AdHopHTA checklist. Health outcomes were expected to be at least equal to the current strategy. Annual cost savings of £637,000 were estimated resulting primarily from a reduction in the proportion of patients receiving intravenous infusional chemotherapy regimens. The result was not sensitive to any parameter. The data driving the main cost saving came from a small clinical audit. We recommended this finding was confirmed in a larger population.ConclusionsThe method could be used to evaluate testing changes elsewhere. The results of the case study may be transferable to other jurisdictions where the organization of cancer services is fragmented.
Open manifolds with non-homeomorphic positively curved souls
Authors: GONZÁLEZ-ÁLVARO DAVID , ZIBROWIUS MARCUS 
Published: July 2019

AbstractWe extend two known existence results to simply connected manifolds with positive sectional curvature: we show that there exist pairs of simply connected positively-curved manifolds that are tangentially homotopy equivalent but not homeomorphic, and we deduce that an open manifold may admit a pair of non-homeomorphic simply connected and positively-curved souls. Examples of such pairs are given by explicit pairs of Eschenburg spaces. To deduce the second statement from the first, we extend our earlier work on the stable converse soul question and show that it has a positive answer for a class of spaces that includes all Eschenburg spaces.
How “Peasant Apartments” Could Undermine Rural Governance in China: Spatial Realignment, Moral Reconfiguration and Local Authority
Authors: Yep Ray , Wu Ying 
Published: July 2019

AbstractA seismic change in the residential pattern is emerging in rural China today: traditional rural houses have been rapidly erased from the face of the countryside with large numbers of peasants being relocated to modern high-rise buildings. This process of “peasant elevation” has had a monumental impact on rural China. It redefines the entitlement to land use by the rural citizenry and negotiations for a new regime of property rights concerning land administration, while, most importantly, it undermines the position of the local state in rural China, whose authority is an aggregation of three distinctive elements: coercive power inherent in the state apparatus, control over economic resources, and resonance with local morality. Based on original data collected in Chongqing, Nantong and Dezhou, this paper argues that the comprehensive uprooting of the Chinese peasantry from the land and the resulting complications have caused moral disorientation among the relocated peasants and fragmentation of local authority. The difficulty in establishing community identity in the new setting has further undermined local governance. This may in turn trigger a wave of social and political tensions that may eventually turn out to be a major political challenge to the regime for years to come.
China and the Global Reach of Human Rights
Authors: Zhang Yongjin , Buzan Barry 
Published: July 2019

AbstractThis article examines the complex dialogical relationship between China and the global reach of human rights. It charts the transformation of China from a human rights exception and a human rights pariah state to an active participant in, and shaper of, global human rights governance. It looks at such transformation as dynamic social and political processes full of contradictions and the negotiated outcome of China's communicative engagement with “moral globalization” in a world morally divided on the meaning of human rights. It contends that the global reach of human rights understood asadvancingrather thanperfectingglobal justice will always remain contentious, as it is contingent on the possibility of open public reasoning across cultures and national boundaries in a global moral conversation. It also argues that China has resourcefully used the idiom of human rights for two specific purposes. One is to justify and rationalize its “developmental relativism” as an excuse for practices that condone continued political repression in China; the other is to internalize politics of contestation within the institutions of global human rights governance by shifting the centre of gravity of both the normative debate and the practical application of human rights.
The English disease in Finnish compound processing: Backward transfer effects in Finnish–English bilinguals
Authors: Bertram Raymond , Kuperman Victor 
Published: July 2019

AbstractMost English compounds are spaced compounds, whereas spelling regulations prescribe Finnish compounds to be written in a concatenated format. However, as in English, Finnish compounds are commonly spaced nowadays (e.g., piha juhla ‘garden party’), a phenomenon that we labeled the ‘English disease’. In this eye movement study with Finnish–English bilinguals we investigate whether the reading of a concatenated or illegally spaced Finnish compound is affected by the spelling of an English translation equivalent (ETE). We found that spaced Finnish compounds were read slower than their concatenated counterparts, but this effect was attenuated when ETEs were thought to be spaced. Similarly, concatenated Finnish compounds were read faster when their ETEs were also concatenated. These backward transfer effects are in line with studies that show that processing behavior in L1 is affected by a strong concurrent L2, even when the L1 is the native language as well as the dominant community language.
Confirmation ofS-metolachlor resistance in Palmer amaranth (Amaranthus palmeri)
Authors: Brabham Chad , Norsworthy Jason K. , Houston Michael M. , Varanasi Vijay K , Barber Tom 
Published: July 2019

AbstractS-Metolachlor is commonly used by soybean and cotton growers, especially with POST treatments for overlapping residuals, to obtain season-long control of glyphosate- and acetolactate synthase (ALS)–resistant Palmer amaranth. In Crittenden County, AR, reports of Palmer amaranth escapes followingS-metolachlor treatment were first noted at field sites near Crawfordsville and Marion in 2016. Field and greenhouse experiments were conducted to confirmS-metolachlor resistance and to test for cross-resistance to other very-long-chain fatty acid (VLCFA)–inhibiting herbicides in Palmer amaranth accessions from Crawfordsville and Marion. Palmer amaranth control in the field (soil <3% organic matter) 14 d after treatment (DAT) was ≥94% with a 1× rate of acetochlor (1,472 g ai ha–1; emulsifiable concentrate formulation) and dimethenamid-P (631 g ai ha–1). However,S-metolachlor at 1,064 g ai ha–1provided only 76% control, which was not significantly different from the 1/2× and 1/4× rates of dimethenamid-P and acetochlor (66% to 85%). In the greenhouse, Palmer amaranth accessions from Marion and Crawfordsville were 9.8 and 8.3 times more resistant toS-metolachlor compared with two susceptible accessions based on LD50values obtained from dose–response experiments. Two-thirds and 1.5 timesS-metolachlor at 1,064 g ha–1were the estimated rates required to obtain 90% mortality of the Crawfordsville and Marion accessions, respectively. Data collected from the field and greenhouse confirm that these accessions have evolved a low level of resistance toS-metolachlor. In an agar-based assay, the level of resistance in the Marion accession was significantly reduced in the presence of a glutathione S-transferase (GST) inhibitor, suggesting that GSTs are the probable resistance mechanism. With respect to other VLCFA-inhibiting herbicides, Marion and Crawfordsville accessions were not cross-resistant to acetochlor, dimethenamid-P, or pyroxasulfone. However, both accessions, based on LD50values obtained from greenhouse dose–response experiments, exhibited reduced sensitivity (1.5- to 3.6-fold) to the tested VLCFA-inhibiting herbicides.
Volatile Degassing From Magma Chambers as a Control on Volcanic Eruptions
Authors: Mittal Tushar , Richards Mark A. 
Published: July 2019

AbstractThe loss of volatiles from a magma reservoir affects the magmatic overpressure responsible for driving ground deformation and eruptions. Although the high‐temperature metamorphic aureole around a magma chamber is typically considered to have low permeability, recent theoretical, experimental, and field studies have highlighted the role of transient permeability in magmatic systems. Also, direct measurements suggest that passive degassing is a significant component of total volatile loss in both basaltic and silicic volcanoes. Consequently, the effective permeability of the crust when magma is present in the system can be many orders of magnitude larger than that of exhumed rock samples. We develop a fully coupled porothermoelastic framework to account for both the flow of volatiles as well as associated effects on the stress state of the crust and calculate an analytical solution for spherical geometry. We then combine a magma chamber box model with these solutions to analyze eruption dynamics in magmatic systems. We find that in addition to viscous relaxation, magma recharge, and cooling timescales, the pore pressure diffusion timescale exerts a first‐order control on volcanic eruptions with moderately high crustal permeabilities of order 10−17 to 10−19 m2. We describe a parameter space to identify which components dominate in different regimes for volcanic eruptions according to these different timescales.
Evaporation Study Based on Micromodel Experiments: Comparison of Theory and Experiment
Authors: Geistlinger Helmut , Ding Yi , Apelt Bernd , Schlüter Steffen , Küchler Matthias , Reuter Danny , Vorhauer Nicole , Vogel Hans‐Jörg 
Published: July 2019

AbstractEvaporation—a key process for water exchange between soil and atmosphere—is controlled by internal water fluxes and surface vapor fluxes. Recent studies demonstrated that the dynamics of the water flow in corners determine the time behavior of the evaporation rate. The internal water flux of the porous media is often described by capillary flow assuming complete wetting. Particularly, the crucial influence of partial wetting, that is, the nonlinear contact angle dependency of the capillary flow has been neglected so far. The focus of the paper is to demonstrate that SiO2‐surfaces can exhibit contact angles of about 40°. This reduces the internal capillary flow by 1 order of magnitude compared to complete wetting. First, we derived the contact angle by inverse modeling. We conducted a series of evaporation experiments in a 2‐D square lattice microstructure connected by lognormal distributed throats. We used an explicit analytical power series solution of the single square capillary model. A contact angle of 38° ± 1° was derived. Second, we directly measured the contact angle of the Si‐SiO2 wafer using the Drop Shape Analyzer Krüss 100 and obtained an averaged contact angle of 42° ± 2°. The results support the single square capillary model as an appropriate model for the description of the evaporation process in an ideal square capillary.
Phase‐Field Modeling of Grain Boundary Premelting
Authors: Takei Yasuko 
Published: July 2019

AbstractThe enhancement of grain boundary disorder near the melting temperature, called premelting, has been known for ice, but not for rock. Recently, possible occurrence of premelting in the upper mantle has become a concern because it causes a solid‐state weakening of rock. This is a possible explanation of the seismic low‐velocity zones and weak asthenosphere without invoking melt. In this paper, I introduce an existing thermodynamic model of the grain boundary and discuss the physical mechanism of premelting in a binary eutectic system, which is the simplest case of such a multicomponent system. The model is based on a phase‐field approach and captures both premelting and partial melting. It predicts that even with a very small amount of the secondary component, the temperature at which premelting occurs drastically decreases from just below the melting temperature of the primary component to just below the eutectic temperature. It also predicts that equilibrium dihedral angle of melt can be a partial proxy for the grain boundary disorder. The model explains well the experimentally measured mechanical properties of a binary eutectic system of organic polycrystals (borneol +0.3–1.7% diphenylamine): With a small amount of diphenylamine, diffusivity and shear stress relaxation at the borneol‐borneol grain boundary are significantly enhanced just below the eutectic temperature, which is much lower than the melting temperature of borneol.
cPLA2 activation contributes to lysosomal defects leading to impairment of autophagy after spinal cord injury
Authors: Li Yun , Jones Jace W. , M. C. Choi Harry , Sarkar Chinmoy , Kane Maureen A. , Koh Eugene Y. , Lipinski Marta M. , Wu Junfang 
Published: July 2019

AbstractThe autophagy–lysosomal pathway plays an essential role in cellular homeostasis as well as a protective function against a variety of diseases including neurodegeneration. Conversely, inhibition of autophagy, for example due to lysosomal dysfunction, can lead to pathological accumulation of dysfunctional autophagosomes and consequent neuronal cell death. We previously reported that autophagy is inhibited and contributes to neuronal cell death following spinal cord injury (SCI). In this study, we examined lysosomal function and explored the mechanism of lysosomal defects following SCI. Our data demonstrated that expression levels and processing of the lysosomal enzyme cathepsin D (CTSD) are decreased by 2 h after SCI. Enzymatic activity levels of CTSD and another lysosomal enzyme, N-acetyl-alpha-glucosaminidase, are both decreased 24 h post injury, indicating general lysosomal dysfunction. Subcellular fractionation and immunohistochemistry analysis demonstrated that this dysfunction is due to lysosomal membrane permeabilization and leakage of lysosomal contents into the cytosol. To directly assess extent and mechanisms of damage to lysosomal membranes, we performed mass spectrometry-based lipidomic analysis of lysosomes purified from SCI and control spinal cord. At 2 h post injury our data demonstrated increase in several classes of lysosophospholipids, the products of phospholipases (PLAs), as well as accumulation of PLA activators, ceramides. Phospholipase cPLA2, the main PLA species expressed in the CNS, has been previously implicated in mediation of secondary injury after SCI, but the mechanisms of its involvement remain unclear. Our data demonstrate that cPLA2 is activated within 2 h after SCI preferentially in the lysosomal fraction, where it colocalizes with lysosomal-associated membrane protein 2 in neurons. Inhibition of cPLA2 in vivo decreased lysosomal damage, restored autophagy flux, and reduced neuronal cell damage. Taken together our data implicate lysosomal defects in pathophysiology of SCI and for the first time indicate that cPLA2 activation leads to lysosomal damage causing neuronal autophagosome accumulation associated with neuronal cell death.
Spin transport in antiferromagnetic insulators: progress and challenges
Authors: Hou Dazhi , Qiu Zhiyong , Saitoh Eiji 
Published: July 2019

AbstractSpin transport is a key process in the operation of spin-based devices that has been the focus of spintronics research for the last two decades. Conductive materials, such as semiconductors and metals, in which the spin transport relies on electron diffusion, have been employed as the channels for spin transport in most studies. Due to the absence of conduction electrons, the potential to be a spin channel has long been neglected for insulators. However, since the demonstration of spin transmission through a ferromagnetic insulator, it was realized that insulators with magnetic ordering can also serve as channels for spin transport. Here, the recent progress of spin transport in antiferromagnetic insulators is briefly described with an introduction to the experimental techniques. The observations regarding the temperature dependence of spin transmission, spin current switching and the negative spin Hall magnetoresistance are discussed. We also include the challenges for developing the functionality of antiferromagnetic insulators as well as the unresolved problems from the experimental observations.