bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nivolumab Combined With Brentuximab Vedotin for Relapsed/Refractory Primary Mediastinal Large B-Cell Lymphoma: Efficacy and Safety From the Phase II CheckMate 436 Study
Authors: Zinzani Pier Luigi , Santoro Armando , Gritti Giuseppe , Brice Pauline , Barr Paul M. , Kuruvilla John , Cunningham David , Kline Justin , Johnson Nathalie A. , Mehta-Shah Neha , Manley Thomas , Francis Stephen , Sharma Manish , Moskowitz Alison J. 
Published: August 2019

PURPOSE Primary mediastinal B-cell lymphoma (PMBL) is a rare but aggressive non-Hodgkin lymphoma with poor outcomes in patients with relapsed/refractory (R/R) disease. PMBL is characterized by high expression of programmed death-1 ligand and variable expression of CD30. Nivolumab, an anti–programmed death-1 immune checkpoint inhibitor, and brentuximab vedotin (BV), an anti-CD30 antibody–drug conjugate, may have synergistic activity in R/R PMBL. METHODS The expansion cohort of the open-label, phase I/II CheckMate 436 study enrolled patients with confirmed R/R PMBL who were previously treated with either autologous hematopoietic cell transplantation or two or more prior chemotherapy regimens if ineligible for autologous hematopoietic cell transplantation. Patients received nivolumab (240 mg intravenously) and BV (1.8 mg/kg intravenously) every 3 weeks until disease progression or unacceptable toxicity. Primary end points were investigator-assessed objective response rate (ORR) per the Lugano 2014 criteria and safety. RESULTS Thirty patients with PMBL were treated and evaluable. At a median follow-up of 11.1 months, ORR (95% CI) was 73% (54% to 88%), with a 37% complete remission rate per investigator, and ORR of 70% (51% to 85%), with a 43% complete metabolic response rate per independent review. Median duration of response, median progression-free survival, and median overall survival have not been reached. Eleven responders had consolidation with autologous (n = 5) or allogeneic (n = 6) transplantation. Treatment-related adverse events were reported in 25 patients (83%). Sixteen patients (53%) had grade 3 to 4 treatment-related adverse events; the most common were neutropenia (n = 9), thrombocytopenia (n = 3), and peripheral neuropathy (n = 3). There were no treatment-related deaths. CONCLUSION In patients with R/R PMBL, the combination of nivolumab plus BV represents a promising option, with high antitumor activity and a manageable safety profile.
Cockroaches use diverse strategies to self-right on the ground
Authors: Li Chen , Wöhrl Toni , Lam Han K. , Full Robert J. 
Published: August 2019

ABSTRACTTerrestrial animals often must self-right from an upside-down orientation on the ground to survive. Here, we compared self-righting strategies of the Madagascar hissing, American and discoid cockroaches on a challenging flat, rigid, low-friction surface to quantify the mechanical principles. All three species almost always self-righted (97% probability) when given time (30 s), frequently self-righted (63%) on the first attempt, and on that attempt did so in 1 s or less. When successful, two of the three species gained and used pitch and/or roll rotational kinetic energy to overcome potential energy barriers (American 63% of all attempts and discoid 78%). By contrast, the largest, heaviest, wingless cockroach (Madagascar hissing) relied far less on the energy of motion and was the slowest to self-right. Two of the three species used rolling strategies to overcome low potential energy barriers. Successful righting attempts had greater rolling rotation than failed attempts as the center of mass rose to the highest position. Madagascar hissing cockroaches rolled using body deformation (98% of all trials) and the American cockroach rolled using leg forces (93%). By contrast, the discoid cockroach overcame higher and a wider range of potential energy barriers with simultaneous pitching and rolling using the wings (46% of all trials) and legs (49%) equally to self-right. Our quantification revealed the performance advantages of using rotational kinetic energy to overcome the potential energy barrier and rolling more to lower it, while maintaining diverse strategies for ground-based self-righting.
Market Segmentation and Software Security: Pricing Patching Rights
Authors: August Terrence , Dao Duy , Kim Kihoon 
Published: August 2019

The patching approach to security in the software industry has been less effective than desired. One critical issue with the status quo is that the endowment of “patching rights” (the ability for a user to choose whether security updates are applied) lacks the incentive structure to induce better security-related decisions. However, producers can differentiate their products based on the provision of patching rights. By characterizing the price for these rights, the optimal discount provided to those who relinquish rights and have their systems automatically updated in a timely manner, and the consumption and protection strategies taken by users in equilibrium as they strategically interact because of the security externality associated with product vulnerabilities, it is shown that the optimal pricing of these rights can segment the market in a manner that leads to both greater security and greater profitability. This policy greatly reduces unpatched populations and has a relative hike in profitability that is increasing in the extent to which patches are bundled together. Social welfare may decrease when automated patching costs are small because strategic pricing contracts usage in the market and also incentivizes loss-inefficient choices. However, welfare benefits when the policy either (1) greatly expands automatic updating in cases in which it is minimally observed or (2) significantly reduces the patching process burden of those who most value the software. This paper was accepted by Anandhi Bharadwaj, information systems.
Detection of Surra (trypanosomiasis) positivity in humans in an outbreak area of Indonesia
Authors: Sawitri Dyah Haryuningtyas , Wardhana April Hari , Sadikin Mohamad , Wibowo Heri 
Published: August 2019

BACKGROUND Surra is an infection caused by a blood protozoan parasite, Trypanosoma evansi, and transmitted by blood-sucking insects. The parasite generally infects only animals; however, it was reported to infect an Indian cattle farmer in 2004, followed by reports of other human cases. The most severe Surra outbreak in Indonesia occurred in Sumba Island during 2010–2012, resulting in the death of more than 2,000 livestock. This study was conducted to explore the serological status of farmers who have intensive contact with their livestock against T. evansi infection in Southwest Sumba district.
METHODS A total of 24 serum samples were collected from farmers living in the Surra outbreak area. All sera were tested using both card agglutination test for trypanosomiasis/T. evansi (CATT/T. evansi) and field enzyme-linked immunosorbent assay (FELISA).
RESULTS Of the 24 serum samples, 4 (16.7%) samples were seropositive for the antigen T. evansi using both tests. This is the first report of human trypanosomiasis (Surra) in Indonesia. Unfortunately, the clinical manifestations of farmers with positive Surra infection were not reported because all sera samples used in this study were obtained from the Public Health Service with no reports of clinical signs from the respondents.
CONCLUSIONS Farmers living in the Surra outbreak area have a high risk of being infected with T. evansi due to their potential frequent contact with Surra vectors. Therefore, T. evansi infection in humans requires attention as it might have the potential to develop as a new emerging zoonotic disease in Indonesia.
Iatrogenic Hepatic Portal Venous Gas in a Patient With Crohn's Disease After Colonoscopy
Authors: Mubarik Ateeq , Siddiqui Salaah , Iqbal Arshad Muhammad , Mohammed Sohaib Khaleel , Muddassir Salman , Eddib Abdulmagid , Herraka Ihab 
Published: August 2019

ABSTRACT
Hepatic portal venous gas is a radiologic sign and is associated with several abdominal disorders. The prognosis and survival of the patient depends on the underlying etiology. Most cases respond to broad-spectrum antibiotics, but some may need surgical intervention. We report a case of hepatic portal venous gas after colonoscopy in a patient with Crohn's disease.
Er hod gegeybm ales far de yi:dn‘He gave the Jews everything’: On the emergence of prepositional dative marking withfarin Transcarpathian Yiddish
Authors: Krogh Steffen 
Published: August 2019

AbstractUriel Weinreich’s seminal study “Western Traits in Transcarpathian Yiddish” (inFor Max Weinreich on his Seventieth Birthday: Studies in Jewish languages, literature, and society, 245–264. The Hague: Mouton) brought a feature into focus that is characteristic not only of Transcarpathian Yiddish, but also of the Haredi idioms descending from it. In the eyes of many representatives of secular Yiddish, it has become a hallmark of so-called Hungarian Yiddish, i.e. Haredi Yiddish derived from Central Yiddish subdialects spoken in Hungary with its 1914 borders. The feature in question is the consistent replacement of nominal dative objects by a prepositional phrase introduced byfar‘for, to’. It is tempting to ascribe the rise of the construction to contact-induced influence from Hungarian, which, for historical reasons, occupies an extraordinarily firm position among Jews living in the Transcarpathian area. A major obstacle to such an assumption is, however, that Hungarian itself does not employ prepositions at all. Being an agglutinative language, it expresses grammatical categories of the noun phrase by means of suffixation.In my paper, I will argue that a constructional borrowing from Hungarian can nevertheless be the source of the feature under scrutiny. To substantiate this assumption, another (more straightforward) example of the Hungarian impact on the prepositional system of Transcarpathian Yiddish – the employment of the prepositionof(St Yid.oyf‘on/onto’) to indicate movement in the direction of geographical locations – will be discussed as well.
The Phenomenonвласть(‘power’) as a Part of Russian Phraseosemantic Worldview
Authors: Melikyan Vadim , Melikyan Anna , Kasatkina Elena 
Published: August 2019

SummaryThe article is devoted to the complex analysis on the phenomenonвласть(‘power’) as a part of the Russian phraseological worldview. The most important social conscience spheres of the phenomenonвластьare defined: politics, economics, sociology, psychology and philosophy. Accordingly, the five most significant micro-concepts, i. e. the particular cognitive fields (‘power in politics’, ‘power in economics’, ‘power in society’, ‘power in psychology’, ‘power in philosophy’) as well as macroconcept (the common cognitive field)властьare described; phraseological units objectifying this phenomenon are singled out; the phraseosemantic fieldвластьis built on the basis of meaningfulness of certain semantic features for the phenomenon characterization and for the common understanding of the conceptвластьin the Russian phraseology; the integral and differentiating features of the cognitive and phraseosemantic fields are revealed.The research is based on both linguistic data and on material from politics, economics, sociology, psychology, philosophy and cultural studies. Thus, the issues analyzed in the article are viewed in terms of the contemporary integral paradigm of cross-disciplinary scientific knowledge. As a result, the syncretic essence of the conceptвластьthat includes two opposite and incompatible principlesгосподство(‘supremacy’) andподчинение(‘submission’) are brought out. The national and cultural specificity of the Russian phraseosemantic worldview and the peculiarities of the Russian linguistic society in the aspect of the phenomenonвласть(‘power’) are established.
Recreational Basketball Small-Sided Games Elicit High-Intensity Exercise With Low Perceptual Demand
Authors: Stojanović Emilija , Stojiljković Nenad , Stanković Ratko , Scanlan Aaron T. , Dalbo Vincent J. , Milanović Zoran 
Published: August 2019

Abstract
Stojanović, E, Stojiljković, N, Stanković, R, Scanlan, AT, Dalbo, VJ, and Milanović, Z. Recreational basketball small-sided games elicit high-intensity exercise with low perceptual demand. J Strength Cond Res 35(11): 3151–3157, 2021—The purpose of this study was to describe and compare the internal and external load imposed on players during 1-a-side, 2-a-side, and 3-a-side recreational basketball small-sided games (SSGs). Twelve recreationally active, male college students were monitored across 10 minutes of 1-a-side, 2-a-side, and 3-a-side basketball SSG. Internal load variables included continuous measurement of heart rate (HR) responses, as well as rating of perceived exertion (RPE) and blood lactate concentration (BLa), after each game. External load variables included measurement of the total distance covered as well as the frequency of accelerations and decelerations. Blood lactate concentration and RPE were moderately (p < 0.05) greater in 1-a-side SSG than 3-a-side SSG. Total accelerations and decelerations were higher in 1-a-side and 2-a-side SSG compared with 3-a-side SSG (p < 0.05, moderate-large). All SSG formats resulted in players spending more time (p < 0.05, moderate-large) at higher HR intensities (81–100% HRmax) than lower intensities (≤80% HRmax). Furthermore, players covered greater distances (p < 0.05, large-very large) at lower intensities (0–12 km·h−1) and completed more accelerations and decelerations (p < 0.05, large-very large) at lower intensities (<2 m·s−2) than at higher intensities across SSG formats. Basketball SSG consisting of 1–3 players elicits an intermittent activity profile, promoting the extensive utilization of anaerobic and aerobic metabolism pathways, which potentially can lead to marked improvements in cardiovascular and musculoskeletal fitness in the general population when administered in recreational settings. Moreover, recreational basketball SSG with only 1 player per team elicits higher BLa, RPE, distances covered at low speeds as well as acceleration and deceleration volumes than SSG with 3 players per team.
Correlation of Fiber-Type Composition and Sprint Performance in Youth Soccer Players
Authors: Metaxas Thomas , Mandroukas Athanasios , Michailidis Yiannis , Koutlianos Nikolaos , Christoulas Kosmas , Ekblom Bjorn 
Published: August 2019

Abstract
Metaxas, T, Mandroukas, A, Michailidis, Y, Koutlianos, N, Christoulas, K, and Ekblom, B. Correlation of fiber-type composition and sprint performance in youth soccer players. J Strength Cond Res 33(10): 2629–2634, 2019—The aim of this study was to examine the correlation between muscle fiber type and sprint performance in elite young soccer players of different age groups of the same team. Twenty-eight young players participated in this study (group U15, n = 8; group U13, n = 9; and group U11, n = 11). Anthropometric assessments, acceleration (10 m), and Bangsbo modified sprint test (30 m) were performed. Muscle biopsies were obtained from the vastus lateralis, and after that, fiber-type composition was determined by immunohistochemistry. No significant correlations were found between the sprint test and muscle fiber distribution for the groups U13 and U11 (p > 0.05). Also, no correlations were found between cross-sectional areas in the types of fibers with the sprint test in all groups (p > 0.05). A positive correlation was found between type I fibers and the performance in the acceleration test (10 m) (r = 0.77, p < 0.05) was found only in group U15 and a negative correlation between type IIA fibers and the performance in the acceleration test (10 m) (r = −0.89, p < 0.05). The correlations were observed only in group U15, which may indicate that the duration and the intensity of the soccer systematic training can affect the plasticity of the muscle fibers. Specific soccer training in youth is one of the factors that can affect fiber-type plasticity. The specific training programs and status of U15 are more intensive, and the exercises are oriented more to improve physical fitness.
Experimental Study on Road Base Material of Geopolymer Recycled Concrete
Authors: Zhu Zhiduo , Gu Suen , Tang Zhen , Song Lei 
Published: August 2019

Abstract
In order to treat and recycle massive waste concrete, ground waste concrete powder (GWCP) and fly ash (FA) were utilized to produce a geopolymer, a kind of cementitious material. The geopolymer and recycled concrete aggregates (RCAs) were then used to produce geopolymer recycled concrete (GRC), which can be used as a road base material. The feasibility of GRC as a road base material was analyzed by a series of tests, including the mixture ratio test of the geopolymer, road performance test of RCAs, and the tests for mechanical properties of GRC. The test results show that for the geopolymer, the optimum mixture ratio of GWCP to FA was 30/70 (weight/weight), with the concentration of sodium hydroxide (NaOH) solution being 18 mol/L, and the modulus of water glass being 1.5. Except for the slightly large water absorption content, the sludge content, flat and elongated particle content, and the crushing value of RCAs meet the technical requirements for aggregates of road base. The unconfined compressive strength, splitting strength, uniaxial compression modulus, water stability, and dry shrinkage of GRC meet the requirements of the related codes, indicating that it can be used in road base. GRC is not only capable of solving the problems of waste concrete treatment but can also reduce the exploitation of natural stone, the use of cement, and the emission of air pollutants, bringing obvious environmental, economic, and social benefits.
Fatigue Performance Analysis of GRE Composite Pipes by Conducting Tension-Tension Tests on the Rings Cut from the Pipe
Authors: Mahdavi Hamidreza , Rahimi Gholam Hossein , Farrokhabadi Amin 
Published: August 2019

Abstract
The main purpose of this study is to analyze the fatigue behavior of an industrial (±55°)9 filament-wound glass reinforced epoxy pipe. Fatigue tests are conducted in accordance with ASTM D2992, Standard Practice for Obtaining Hydrostatic or Pressure Design Basis for Fiberglass (Glass-Fiber-Reinforced Thermosetting-Resin) Pipe and Fittings, but instead of the entire pipe, rings cut from the pipe are used in the tests. This standard proposes a frequency of 0.42 Hz and stress ratio of R = 0.05. Tension-tension fatigue tests are performed on the rings at different load levels from 60 to 90 % of the ultimate hoop strength of the pipe. After the tests, the maximum pressure and maximum hoop stress curves versus the number of cycles to fatigue failure are presented. A comprehensive discussion about the importance of substituting the ring test method with ASTM D2992 standard test methods to determine the long-term performance of the composite pipes in the future is presented. The microscopic fatigue failure mechanisms of the rings are also characterized and interpreted using a scanning electron microscope.
Detailed Stratigraphy of the Vendian Tira and Lower Danilovka Horizons in the Southwestern Siberian Platform
Authors: Mel’nikov N.V. 
Published: August 2019

Abstract
—A member and bed-by-bed division of the Upper Vendian formations in the boreholes drilled in the Baikit anteclise and the Angara fold zone in the west of the Siberian Platform has revealed sedimentation gaps above the Danilovka Horizon and above and within the Tira Horizon as well as amplitude erosion of the sediments. Lower beds appear in the above-gap Il’bokich basal argillaceous-dolomite-marl member of the Katanga Formation of the Danilovka Horizon. The thicknesses of all beds gradually increase from north (Baikit anteclise) to south in the Angara fold zone. The upper members of the Tira Horizon did not accumulate below the gap in the north. The Yurubchen Plateau (uplift) was in this area. South of it, the formation thicknesses increase; there are apparently no gaps in the Beryambinskaya area of the Angara fold zone. The Il’bokich member makes up the top of the Moshakovka Formation but is part of the Danilovka Horizon. The Moshakovka Formation spans the top of the Tira Horizon and the bottom of the Danilovka Horizon. In general, stratigraphic bodies in areas with a rapid increase in the tectonic-downwarping amplitudes have a typical geologic structure.
Marine Isotopic Stage 3 in Northeastern Europe: Geochronology and Events
Authors: Zaretskaya N.E. , Korsakova O.P. , Panin A.V. 
Published: August 2019

Abstract
—The paper presents new lithological, geochronological, and biostratigraphic data on the studied sections of the Middle Valdai interstadial sediments in the sections of two terraces in the basin of the Severnaya Dvina River and on the southern coast of the Kola Region and in its southwestern part. The obtained data are correlated with the data available for other regions of northeastern Europe. The Severnaya Dvina River was found to have flowed into a marine reservoir existed in the White Sea basin throughout the Middle Valdai time corresponding to Marine Isotopic Stage 3 (MIS 3). The alluvial sedimentation in the river catchment area occurred in the environment of base level instability and permanently changing climate. In northeastern Europe, the warmest (optimum) intervals are related to the time spans of 47–43 and 31.3–29.2 cal. ka BP. In general, the available data point to 12 warming and cooling episodes in northeastern Europe.