bluuebunny/crossref_metadata_2025_split huggingface dataset:
Incidence, Predictors, and Clinical Impact of Early Prasugrel Cessation in Patients With ST‐Elevation Myocardial Infarction
Authors: Koskinas Konstantinos C. , Zanchin Thomas , Klingenberg Roland , Gencer Baris , Temperli Fabrice , Baumbach Andreas , Roffi Marco , Moschovitis Aris , Muller Oliver , Tüller David , Stortecky Stefan , Mach Francois , Lüscher Thomas F. , Matter Christian M. , Pilgrim Thomas , Heg Dik , Windecker Stephan , Räber Lorenz 
Published: April 2018

Background

Early withdrawal of recommended antiplatelet treatment with clopidogrel adversely affects prognosis following percutaneous coronary interventions. Optimal antiplatelet treatment is essential following
ST
‐segment elevation myocardial infarction (
STEMI
) given the increased risk of thrombotic complications. This study assessed the frequency, predictors, and clinical impact of early prasugrel cessation in patients with
STEMI
undergoing primary percutaneous coronary interventions.

Methods and Results

We pooled patients with
STEMI
discharged on prasugrel in 2 prospective registries (Bern
PCI
Registry [
NCT
02241291] and
SPUM
‐
ACS
(Inflammation and Acute Coronary Syndromes) [
NCT
01000701]) and 1
STEMI
trial (
COMFORTABLE
‐
AMI
(Comparison of Biomatrix Versus Gazelle in ST‐Elevation Myocardial Infarction) [
NCT
00962416]). Prasugrel treatment status at 1 year was categorized as no cessation; crossover to another P2Y
12
‐inhibitor; physician‐recommended discontinuation; and disruption because of bleeding, side effects, or patient noncompliance. In time‐dependent analyses, we assessed the impact of prasugrel cessation on the primary end point, a composite of cardiac death, myocardial infarction, and stroke. Of all 1830 included patients (17% women, mean age 59 years), 83% were treated with new‐generation drug‐eluting stents. At 1 year, any prasugrel cessation had occurred in 13.8% of patients including crossover (7.2%), discontinuation (3.7%), and disruption (2.9%). Independent predictors of any prasugrel cessation included female sex, age, and history of cerebrovascular event. The primary end point occurred in 5.2% of patients and was more frequent following disruption (hazard ratio 3.04, 95% confidence interval,1.34–6.91;
P
=0.008), without significant impact of crossover or discontinuation. Consistent findings were observed for all‐cause death, myocardial infarction, and stent thrombosis following prasugrel disruption.

Conclusions

In this contemporary study of patients with
STEMI
, early prasugrel cessation was not uncommon and primarily involved change to another P2Y
12
‐inhibitor. Disruption was the only type of early prasugrel cessation associated with statistically significant excess in ischemic risk within 1 year following primary percutaneous coronary interventions.
İSTATİSTİKSEL KALİTE KONTROL TEKNİKLERİ İLE OTOMOTİV SEKTÖRÜNDE BİR UYGULAMA
Authors: AYDIN Z. Berna , ARIKAN KARGI V. Sinem 
Published: April 2018

Yoğun rekabetin yaşandığı günümüz koşullarında, firmaların
kaliteli ürünler üretmesi ve üretimlerini tüketicinin istekleri doğrultusunda
plânlaması önemlidir. Firmaların,
günümüz rekabet ortamında varlığını sürdürebilmesi için kendilerini sürekli
geliştirmesi ve ürün kalitesini sürekli iyileştirmesi zorunludur. Ürün
kalitesinin iyileştirilmesi, uluslararası standartlara uygunluğu, üretilen
ürünlerin kalite düzeylerinin araştırılması istatistiksel kalite kontrol
teknikleri yardımıyla yapılır. Bir sürecin kontrol altında olup olmadığı
kontrol grafikleri yardımıyla belirlenir. Süreç yeterliliğinin ölçülmesinde de,
Cp ve Cpk süreç indeksleri hesaplanılarak sürecin
yeterliliği belirlenir.

Çalışmamız Bursa ilinde otomotiv sektöründe yer alan bir fabrikada
üretilen otomobillerin ön kapı dinamik kapanma hız ölçümlerinin istatistiksel
olarak kontrol altında olup olmadığı X ortalama ve S kontrol grafikleri ile belirlenmeye
çalışılmıştır. Bu amaçla 2017 yılı ocak ayına ait ön kapı kapanma hız
ölçümlerine ilişkin veriler, SPSS 17 paket programı yardımıyla sürecin kontrol
altında olup olmadığı incelenerek, süreç
ve makine yeterlilik indeksleri hesaplanmıştır. Çalışmanın sonucunda, sürecin kontrol altında ve yeterli olduğu
görülmüştür. Sürecin makine yeterlilik indeksi hesaplandığında,
sol ön kapanma hızı yeterli iken, sağ ön kapanma hızlarına ilişkin değerlerin
yetersiz olduğu görülmüştür.
The Interpretation of the Sacrament of the Eucharist as Palingenesis According to Foix-Candale
Authors: Moreschini Claudio 
Published: April 2018

AbstractBy means of a dialogue between Hermes, also known as Mercury, and his son Tat, the thirteenth treatise of the Corpus Hermeticum explains how Hermes learned from God what is meant by “palingenesis,” usually translated as “rebirth,” and how, in the aftermath of this explanation, Tat’s soul was transformed. In his lengthy commentary on this treatise, the sixteenth-century Christian Hermetist François Foix-Candale interprets the Hermetic palingenesis as a foreshadowing of the Christian doctrine of rebirth by means of the sacrament of the Eucharist, and explains how this sacrament, which at the time had been rejected by the Lutherans among others, may contain the transformation of the body of Christ and the regeneration of those partaking of it through Communion.
The Impact of Overweight/Obesity Duration and Physical Activity on Medical Multimorbidity: Examining the WATCH Paradigm
Authors: Dankel Scott J. , Loenneke Jeremy P. , Loprinzi Paul D. 
Published: April 2018

Purpose: The “fat-but-fit” paradigm has been evaluated. However, the duration of overweight/obesity within the “fat-but-fit” paradigm (ie, assessing body mass at more than 1 time point) has not been extensively evaluated, which was this study’s purpose. Design: Cross-sectional. Setting: National Health and Nutrition Examination Survey 2003 to 2006. Participants: Ages 36 to 85; N = 3621. Measures: Physical activity assessed via accelerometry. Medical multimorbidity was assessed via physician diagnosis of 13 chronic diseases. Height and body mass were directly measured for current body mass index (BMI), and 10-year prior BMI was calculated using current height and self-reported weight 10 years prior. Six mutually exclusive groups were created: (1) active, normal weight now and 10 years ago; (2) inactive, normal weight now and 10 years ago; (3) active, overweight/obese now but not 10 years ago; (4) active, overweight/obese now and 10 years ago; (5) inactive, overweight/obese now but not 10 years ago; and (6) inactive, overweight/obese now and 10 years ago. Analysis: Logistic regression. Results: Compared to group 1, adjusted odds ratios (ORs) were as follows: group 2: OR = 2.0 ( P = .004), group 3: OR = 1.7 ( P = .004), group 4: OR = 2.5 ( P < .001), group 5: OR = 2.9 ( P < .001), and group 6: OR = 4.8 ( P < .001). Conclusions: All patterns of weight change/duration and activity level altered the odds of medical multimorbidity, suggesting that the duration of overweight/obesity should also be taken into consideration when assessing the “fat-but-fit” paradigm.
Barriers to cervical screening and interest in self-sampling among women who actively decline screening
Authors: Bennett Kirsty F , Waller Jo , Chorley Amanda J , Ferrer Rebecca A , Haddrell Jessica B , Marlow Laura AV 
Published: April 2018

Objectives Understanding why some women actively decline cervical screening could contribute to tailored intervention development. We explored reasons for non-participation in cervical screening among women who had made an active decision not to attend in the future. We also explored interest in human papillomavirus self-sampling. Methods In a population-based survey of women in Great Britain, home-based computer-assisted interviews were carried out with screening eligible women. Women reported their intention to attend for screening when next invited. They endorsed predefined barriers to screening and indicated their interest in human papillomavirus self-sampling. Results Women who had actively declined screening and those who intended to go but were currently overdue (n=543) were included in this analysis. Women who had made an active decision not to be screened in the future were more likely to endorse the barriers ‘I have other more important things to worry about’ and to perceive screening to be of low relevance based on their sexual behaviour. Most participants (70%) indicated that they would be interested in human papillomavirus self-sampling. Interest in self-sampling was greater among those who reported having had a bad experience of screening in the past, were too busy or embarrassed to attend, or would not want a man to carry out the test. Conclusions Women who had made an active decision not to attend screening felt it was of low relevance to them and that they had more important things to worry about. Shifting the perceived cost–benefit ratio for these women by offering human papillomavirus self-sampling might increase screening participation in this group.
Business Cycles in a Three-sector Growth Model with Portfolio Equilibrium between Land, Gold and Capital
Authors: Zhang Wei-Bin 
Published: April 2018

This study generalises a growth model proposed by Zhang (2016) through allowing all the time-dependent variables to be time-dependent. Zhang’s model deals with dynamic interdependence between capital accumulation and environmental change, with portfolio equilibrium among land, gold and physical wealth in a multi-sector general equilibrium framework. The model explains the dynamics of prices, rents and distribution of land, gold, physical wealth and environmental change on the basis of micro-economic foundation. This article generalises the model to explain business cycles due to different exogenous shocks. We simulate the motion of the economy and conduct comparative dynamic analysis to demonstrate business cycles due to periodic oscillations in the propensity to use gold, the propensity to consume housing, the propensity to consume industrial goods, the propensity to consume agricultural goods, the propensity to save, and the tax rate on the consumption of industrial goods. JEL Classification: O41, D41, E32
Maxillary Growth in Cleft Lip and Palate Patients, With and Without Vomerine Flap Closure of the Hard Palate at the Time of Lip Repair
Authors: Hay Norman , Patel Brijesh , Haria Priya , Sommerlad Brian 
Published: April 2018

Objective: To assess the midterm effect on maxillary growth of vomerine flap (VF) closure of the hard palate, at the time of lip repair. Design: A retrospective analysis of prospectively collected nonrandomized data. Interventions: Consecutive participants with a unilateral cleft lip and palate (UCLP) were operated on, at 3 months of age, by the same surgeon. They were divided into 2 groups, those who had a VF and those who did not (non-VF). Setting: Participants were treated at 2 hospitals in the United Kingdom. Participants: Twenty-eight participants in the VF group and 24 participants in the non-VF group attended follow-up at 10 years of age. Main Outcome Measures: Standardized lateral cephalometric radiographs were taken at 10 years. Following tracing and digitization, parameters to assess the maxillary growth were analyzed. Results: No statistically significant differences were found in the anterior–posterior or vertical skeletal cephalometric parameters. Conclusions: The results of this study support the statement that VF repair does not significantly affect maxillary growth in patients with a UCLP, when assessed cephalometrically at 10 years of age. It should be noted that at this age, growth is not yet complete.
“Music & Memory” and improved swallowing in advanced dementia
Authors: Cohen Dan , Post Stephen G , Lo Angela , Lombardo Robin , Pfeffer Brandon 
Published: April 2018

Background Dysphagia and difficulty with eating affects a significant portion of individuals with advanced dementia. Such problems with oral intake can have serious health consequences including mealtime distress, dehydration and malnutrition, aspiration, reduced quality of life, and increased mortality risk. Design We present the first data indicating that “Music & Memory” interventions improve swallowing in individuals with advanced dementia, thereby making oral feeding easier and potentially diminishing reliance on PEG. Setting Columbia Health Care Center, Wyocena, WI (with Music&Memory.org, Mineola, NY and Stony Brook University). Participants Residents with advanced dementia (N = 5). Measurements: Observation by eight professional caregivers. Results (1) Enhanced swallowing mechanism with Music & Memory prior to dining; (2) decreased incidents of choking during mealtime; (3) improved nutritional status; (4) reduced weight loss; (5) reduced need for speech interventions; (6) enhanced quality of life. Conclusions The preliminary results call for additional research.
Creation of Exotic π-Electron Systems by Introduction of Heavy Elements and Expansion of the Concept of Aromaticity
Authors: Saito Masaichi 
Published: April 2018

AbstractWe succeeded in the synthesis of dilithio-stannoles and a -plumbole, which possess aromatic character, as evidenced by structural analysis and quantum-chemical calculations, and accordingly the concept of aromaticity can now be expanded to tin- and lead-containing π-conjugated systems. Reactivity of dilithio-stannoles and a -plumbole toward alkyl-, aryl-, and metal-halides was investigated. Stepwise oxidation of a dilithiostannole using oxygen gas yielded a 1,2-dilithiobistannole and a 1,3-dilithioterstannole. The combination of the aromatic dianionic ligands and transition metals produced unique electronic structures that could not be created by the use of cyclopentadienyl and its related carbon-only ligands. These new findings would inspire a new chemical bond theory, materials science, and catalytic chemistry. The serendipitous formation of a pentaorganostannate bearing five carbon substituents and a dibenzopentalenide is also described.
Molecular Imprinting: Materials Nanoarchitectonics with Molecular Information
Authors: Komiyama Makoto , Mori Taizo , Ariga Katsuhiko 
Published: April 2018

Abstract
Combining nanotechnology with other science disciplines is necessary to produce various materials with nanoscale structural and functional information, which is nanoarchitectonics, a novel paradigm to create useful materials. One of the basic ideas in nanoarchitectonics is use of molecular-level information to structurally design functional materials. This strategy is indeed used in some existing science fields and technical realms. For example, molecular imprinting techniques provide functional materials possessing molecular information inside fabricated materials. Revisiting this idea with the nanoarchitectonics concept would have great meaning toward unification of individual research disciplines into one key approach. In this review, we survey fundamentals and recent trends in molecular imprinting in consideration of nanoarchitectonics. Here, aspects and examples of molecular imprinting are surveyed from fundamentals to advanced applications: (i) fundamental preparation of molecular imprinting polymers in the form of nanoparticles, nanofibers, thin films, and monolayers; (ii) surface coverage, post-modification, and introduction of new functional groups; (iii) imprinted materials with controllable guest binding by external stimuli such as photo-responsive, temperature-sensitive, pH-sensitive, solvent-dependent, and multi-stimuli responsive materials; (iv) imprinting using proteins as template and protein stamping; (v) use of cyclodextrins as functional monomers; (vi) advanced functions including highly sensitive and selective sensors combined with DNA aptamers and enzymatic reactions, post-imprinting for sophisticated sensors, and applications to drug delivery systems.
The influence of age and osteoporosis on bone marrow stem cells from rats
Authors: Sanghani-Kerai A. , Osagie-Clouard L. , Blunn G. , Coathup M. 
Published: April 2018

Objectives This study aimed to assess the effect of age and osteoporosis on the proliferative and differentiating capacity of bone-marrow-derived mesenchymal stem cells (MSCs) in female rats. We also discuss the role of these factors on expression and migration of cells along the C-X-C chemokine receptor type 4 (CXCR-4) / stromal derived factor 1 (SDF-1) axis. Methods Mesenchymal stem cells were harvested from the femora of young, adult, and osteopenic Wistar rats. Cluster of differentiation (CD) marker and CXCR-4 expression was measured using flow cytometry. Cellular proliferation was measured using Alamar Blue, osteogenic differentiation was measured using alkaline phosphatase expression and alizarin red production, and adipogenic differentiation was measured using Oil red O. Cells were incubated in Boyden chambers to quantify their migration towards SDF-1. Data was analyzed using a Student’s t-test, where p-values < 0.05 were considered significant. Results CD marker expression and proliferation of the MSCs from the three groups was not significantly different. The young MSCs demonstrated significantly increased differentiation into bone and fat and superior migration towards SDF-1. The migration of SDF-1 doubled with young rats compared with the adult rats (p = 0.023) and it was four times higher when compared with cells isolated from ovariectomized (OVX) osteopenic rats (p = 0.013). Conclusion Young rat MSCs are significantly more responsive to osteogenic differentiation, and, contrary to other studies, also demonstrated increased adipogenic differentiation compared with cells from adult and ostopenic rats. Young-rat-derived cells also showed superior migration towards SDF-1 compared with MSCs from OVX and adult control rats. Cite this article: A. Sanghani-Kerai, L. Osagie-Clouard, G. Blunn, M. Coathup. The influence of age and osteoporosis on bone marrow stem cells from rats. Bone Joint Res 2018;7:289–297. DOI: 10.1302/2046-3758.74.BJR-2017-0302.R1.
Patriotism and Bellicism in German and Dutch Epics of the Enlightenment
Authors: van der Haven Cornelis 
Published: April 2018

Abstract
The German and Dutch historiography of eighteenth-century patriotismdefines two different forms of patriotism. It is either presented as an enlightenedand virtuous-eudemonic form of ʻlove for the fatherlandʼ based on reason, or asan ideology that foreshadows nineteenth-century emphatic forms of aggressivenationalism. A critical reading of the mid-eighteenth-century epics Cyrus byChristoph Martin Wieland and De Gevallen van Friso by Willem van Haren showsthat the discourses are strongly intertwined. Heroism in these epics is based on apersonal experience of war acts and no longer on distanced and ʻtheatricalʼexperiences of the military spectacle. It confronts us with aggressive war fantasiesrelated to early bellicism, as well as with pacifist statements. In Cyrus, forinstance, the sentimental warrior inspires his fellow-soldiers to offer their bloodin the struggle against the enemy, but he has doubts about the war and showscompassion with the enemy. Explorations of the effects of individual emotionson the battlefield, prepared both further idealisations of patriotic war acts and amore critical literary approach to war and fatherland.
Der neue Diamant: Verfremdungseffekte bei E. S. Özdamar
Authors: Federmair Leopold 
Published: April 2018

Abstract
Emine Sevgi Özdamar is a representative author of German-Turkishliterature, which has been growing in size and importance during the last decades.The present article assumes that authors who use norm-deviant language(diverging from established linguistic practices as well as from conventional andmodern literary forms of expression) are particularly capable of making innovativecontributions to contemporary German literature. In Özdamar’s narrativeworks uncertain linguistic attitudes and deficient or “odd” verbalizations canproduce aesthetically valuable estrangement effects –; a conception recallingBertolt Brecht’s literary theory, as well as Ernst Jandl’s experimentations withwhat he called “heruntergekommene Sprache” (degenerate language). Due,among other factors, to Özdamar’s decision to use predominantly autobiographicalmaterial for her narrations, her exophonic writing accompanies in someworks childlike-naive forms of perception, and diction that can produce similareffects in respect to linguistic norms and habits. We can observe numerousmetaphorical expressions that reveal a playful animistic attitude towards reality.A look at Özdamar’s three-volume autobiographical sequence suggests that theestranging/innovative quality of her literary work decreases with the her gradualintegration into the German linguistic and literary community. Viewed in thislight, the struggle for literaricity would consist of maintaining and renewing theessential “linguistic strangeness” (Marcel Proust) of her style. Such an attitude isdifferent from a globalized (or globalizing) type of literature, which intends toproduce universal linguistic and narrative schemata.
„Literarische Scherze in August W. v. Schlegels Manier von Doktor-Dichter Presheren“
Authors: Birk Matjaž 
Published: April 2018

Abstract
The study of the role of the Slovene national Poet France Prešeren (1800–1849) as mediator of intellectual-aesthetic concepts and literary models of German romantic and their reception in the Slovene literature from 1830 is based on the analysis of literary texts, that were published in chosen German speaking cultural periodics in Laibach (Ljubljana) – the centre of Slovene ethnic territory in the Austrian monarchy. The analysis includes also cultural (nonfictional) texts, which were participating in processes of cultural coding. The research focuses on the adaptation of A.W. Schlegel’s literary epigrammatic model by Prešeren as poet and as an influential actor in the Laibach Slovene and German cultural and literary field in the frame of his fundamental contribution to the constitution of the Slovene poetry and its idiom.
“Harmony and Openness to Many Levels of Reality” – the Thought of Emanuel Swedenborg in the Writings of Czeslaw Milosz
Authors: Bukowski Piotr 
Published: April 2018

AbstractOne of the most important features of Czeslaw Milosz’s (1911–2004) literary output is his dialogue with religious thinkers. The Swedish eighteenth-century theologian and mystic Emanuel Swedenborg is among his important “interlocutors”. The present paper aims at discussing the key motifs in Milosz’s reflections on Swedenborg’s theology as well as defining the specific character of his interpretation of the thought of the author of Arcana Coelestia. In Swedenborg’s work, Milosz looked primarily for a remedy for the disease of modernity, whose most severe symptom is the disintegration of the world, which became subjected to the rule of William Blake’s Urizen. For Milosz the modern man is homeless within the inhuman space of an infinite universe which cannot be grasped by imagination. Swedenborg, on the other hand, restores the vertical points of reference, Heaven and Hell, and at the same time places them within the human soul. The restitution of spatial points of reference is of immense significance to Milosz, who emphasizes that Swedenborg’s system was aimed at liberating imagination, fettered by the scientific world-view. While reading Swedenborg, Milosz remarked also that the cause of Christianity’s weakness lay in its loss of original integrity and unity, and in its theology of marital love characterized by fear and escapism. The source of Milosz’s fascination with Emanuel Swedenborg’s thought has to do, among other things, with the positive and integrating force of Swedenborg’s thought, the idea of uniting man with God, matter with spirit, faith with reason, and language with being.