bluuebunny/crossref_metadata_2025_split huggingface dataset:
And their minds, their minds are not in grief anymore
Authors: Croteau Chantal 
Published: November 2024

Summary“And their minds, their minds are not in grief anymore” is a short creative non‐fiction piece that blurs genre and style. It features a small segment of an interview with Ajarn Manat, the abbot of a modest temple in southern Thailand that had served as temporary housing for tsunami refugees following the devastating wave in December 2004. The interview is preserved in the left column. The right column weaves together a reflection on the moment of the interview and pieces of a different but interconnected archive. The piece can be read in multiple ways, either by preserving columns or flowing seamlessly across.
Clinical characteristics and long‐term outcomes of Venoarterial extracorporeal membrane oxygenation in children with congenital heart disease
Authors: Yu Xindi , Yang Yinyu , Guo Zheng , Shen Jia , Xie Li , Xu Zhuoming , Zhang Haibo , Zhang Wei , Wang Wei 
Published: November 2024

AbstractObjectivesTo analyze the clinical outcomes of extracorporeal membrane oxygenation (ECMO) support in children with congenital heart disease (CHD) after surgery and explore the risk factors associated with mortality during long‐term follow‐up for 3–5 years.MethodsWe conducted a retrospective observational study at Shanghai Children Medical Center (SCMC) from 2017 to 2021 and reviewed the clinical results and laboratory findings of 188 CHD patients who received ECMO support during this period.ResultsThe 5‐year overall survival rate was 56.38% (106/188) among CHD patients who received ECMO support. Kaplan–Meier curve showed residual anatomical malformation (RAM) (p < 0.0001), gastrointestinal bleeding (p = 0.019), single ventricular (SV) (p = 0.028), and pre‐ECMO lactate level >10 mmol/L (p < 0.0001) were significantly associated with higher mortality in follow‐up. Cox analysis identified RAM (p = 0.039) and pre‐ECMO lactate level >10 mmol/L (p < 0.001) as independent risk factors for overall survival. Conversely, a minimum platelet count ≥50 × 109/L (p < 0.001) was found to be a protective factor. Moreover, a competing risk model showed that a CPR time ≥60 min (p < 0.001) was identified as a risk factor for death in patients who failed to be discharged from the hospital.ConclusionsOur study showed characteristics of long‐term follow‐up patients and revealed several risk factors associated with mortality in children with CHD who received ECMO support. These findings can provide valuable insights for clinical decision‐making and contribute to improving patient outcomes.
Review Article: Green Management of IBD—New Paradigms for an Eco‐Friendly Approach
Authors: Cammarota Giovanni , Laterza Lucrezia , Bibbò Stefano , Fusco William , Rozera Tommaso , Di Brino Eugenio , Porcari Serena , Scaldaferri Franco , Ianiro Gianluca , Gasbarrini Antonio , Armuzzi Alessandro 
Published: November 2024

ABSTRACTBackgroundThe worldwide prevalence of inflammatory bowel disease (IBD) is increasing, with its potential evolution as a global disease and a consequent increase in its burden on healthcare systems. These estimates do not factor in the ‘real’ price of IBD, which, beyond curbing career aspirations, instilling social stigma, and impairing the quality of life in patients, could also significantly affect the environment.AimTo highlight potential areas for intervention and develop management strategies aimed at minimising environmental impacts in the field of IBD over time.MethodsVarious aspects of IBD care (organisation of IBD centres, diagnostics and therapeutics) are examined from an environmental sustainability perspective.ResultsEach stage, from the patient's means of transport to the hospital to the physician's diagnostic and therapeutic decisions, contribute to CO2 and waste production. Strategies to contain the environmental impact are feasible. Some are easy to implement, such as ensuring the appropriateness of the diagnostic and therapeutic pathway for patients; others need to be implemented in synergy with healthcare providers' policies and pharmaceutical companies.ConclusionsWith an inevitable increase in the number of patient visits, endoscopies, laboratory testing, and long‐term therapeutic strategies for IBD, the clinical community should be aware of environmental concerns and investigate possible strategies to reduce the environmental impact of IBD care.
Dietary water fly (Notonecta sp.) meal as an alternative protein source for sheep: Effects on performance, nutrient intake, nitrogen balance, and fermentation parameters
Authors: Robles Jimenez Lizbeth E. , Ghavipanje Navid , Renna Manuela , Ortega Octavio Alonso Castelán , Vargas‐Bello‐Pérez Einar , Gonzalez‐Ronquillo Manuel 
Published: November 2024

AbstractIn this study, the inclusion of water fly (Notonecta sp., NT) meal was compared with conventional protein sources such as soybean meal (SBM) and fish meal (FM) in diets destined for sheep, with specific reference to growth performance, nutrient intake, nitrogen balance, and in vitro rumen fermentation parameters. For 21 days, 18 male Suffolk lambs were randomly assigned to three experimental diets fed: (1) SBM at 130 g/kg dry matter (DM), as a plant‐based protein diet; (2) FM at 50 g/kg DM, as an animal‐based protein diet; and (3) NT at 60 g/kg DM, as an insect‐based protein diet, for ad libitum feed intake. DM intake was similar among the treatments. The digestibility of DM (p = 0.006) and organic matter (p = 0.002) in the NT group was lower than that of SBM. In vitro rumen fermentation data showed that there were no differences between the treatments for DM degradation and the production of microbial crude protein. No differences were observed among the treatments in terms of enteric methane production. The NT diet produced the lowest NH3‐N at hours 12 and 24 (p = 0.032 and 0.021, respectively). Overall, the dietary inclusion of NT for fattening lambs could be an alternative feeding strategy without deleterious effects on animal performance.
Effects of quercetagetin on the growth performance, nutrient digestibility, slaughter performance, meat quality, and antioxidant capacity of broiler chickens
Authors: Liang Hui‐qing , Fan Dong‐feng , Hu Wen‐yue , Wu Feng‐yang , Tan Kai , Zhao Peng‐yu , Han Shuai‐juan , Chen Bao‐jiang 
Published: November 2024

AbstractThis study investigated the effects of quercetagetin (QG) on growth performance, nutrient digestibility, meat quality, and antioxidant capacity of broilers. Four hundred 1‐day‐old Cobb broilers were randomly divided into five diets, each with eight replicates and 10 birds per replicate. The diets included a basal diet, and four diets with 25, 50, 100, and 200 mg/kg QG supplemented in basal diet. Body weight on d 21, average daily gain, and average daily feed intake on days 1–21 were quadratically (p < 0.05) increased with increasing QG supplementation. The apparent digestibility of crude protein, ether extract, and total phosphorus increased linearly (p < 0.05) from day 1 to 21, and increased quadratically (p < 0.05) from day 22 to 42. The L* values of leg muscles were lower (p < 0.05) in QG groups than control group. QG supplementation quadratically (p < 0.05) elevated glutathione peroxidase (GSH‐Px) activity and reduced malondialdehyde (MDA) levels in serum. The L* value was negatively correlated with GSH‐Px. These results suggested that QG supplementation (50–100 mg/kg) enhanced early growth, nutrient digestibility, and antioxidant status in broilers, highlighting its functional properties and potential as an additive to improve broiler productivity.
Real‐world experience of paediatric acute promyelocytic leukaemia in the United Kingdom and Ireland
Authors: Vedi Aditi , Leiter Sarah Maria , Memon Irum Latif , Mahendrayogam Arunthethy , Van Rijswijk Elsje , Uparkar Urmila , Shenton Geoff , Trinquand Amelie , Clesham Katherine , McLelland Vanessa , Campbell Helen , Patrick Katharine , Thompson Lyndsey , Baird Susan , Connor Philip , Lancaster Donna , James Beki 
Published: November 2024

SummaryAcute promyelocytic leukaemia (APL), defined by the t(15;17)(q24;q21) translocation, accounts for 5%–10% of paediatric acute myeloid leukaemia cases. All‐trans retinoic acid (ATRA) and arsenic trioxide (ATO) are key treatments, though ATO access varies. We evaluated treatment, complications and survival in 50 UK paediatric APL patients diagnosed between 2014 and 2021. All patients received ATRA and most received ATO. Event‐free survival was lower in high‐risk patients (85% vs. 100%, p = 0.03), and those not receiving ATO at diagnosis. All relapsed patients could be salvaged with ATO. Addressing ATO availability and consistent funding is crucial to ensure timely treatment and improve outcomes.
Greater preservation of SARS‐CoV‐2 neutralising antibody responses following the ChAdOx1‐S (AZD1222) vaccine compared with mRNA vaccines in haematopoietic cell transplant recipients
Authors: Colton Hayley , Barratt Natalie , Temperton Nigel , Hornsby Hailey , Angyal Adrienn , Grouneva Irina , Lindsey Benjamin B. , Kearns Pamela , Barnes Eleanor , Goodyear Carl S. , Richter Alex , Thomas David , Cook Gordon , McInnes Iain B. , Willicombe Michelle , Siebert Stefan , Orchard Kim , Selby Rachael , Bowden Sarah , Collini Paul J. , Pope Ann , Kirkham Amanda , Kronsteiner Barbara , Dunachie Susanna J. , Miller Paul , Clay Jennifer , Hurst Erin , Malladi Ram , Kesavan Murali , Kinsella Francesca , Sanderson Robin , Yong Kwee L. , Rea Daniel , Parry Helen ,   PITCH Consortium, OCTAVE Collaborative Group, OCTAVE‐DUO Investigators, PROSECO Investigators, Lim Sean H. , Snowden John A. , de Silva Thushan I. 
Published: November 2024

SummaryWhilst SARS‐CoV‐2 mRNA vaccines generate high neutralising antibodies (nAb) in most individuals, haematopoietic stem cell transplant (HSCT) and chimeric antigen receptor T‐cell (CAR‐T) recipients respond poorly. HSCT/CAR‐T treatment ablates existing immune memory, with recipients requiring revaccination analogous to being vaccine naive. An optimal revaccination strategy for this cohort has not been defined. Factors predicting immunogenicity following three ancestral SARS‐CoV‐2 vaccines were assessed in 198 HSCT/CAR‐T recipients and 96 healthcare workers (HCWs) recruited to multicentre studies. Only 25% of HSCT/CAR‐T recipients generated nAbs following one dose, with titres 167‐fold and 7‐fold lower than that in HCWs after the first and second doses, respectively. Lower post‐second dose nAb titres were associated with older age, rituximab use, and previous HSCT. ChAdOx1‐S recipients were more likely to generate nAbs compared with mRNA vaccines, with titres comparable to HCWs. In contrast, nAbs were significantly lower in HSCT/CAR‐T recipients than HCWs after mRNA vaccination. The poor first‐dose immunogenicity in HSCT/CAR‐T recipients suggests a minimum licensed dosing interval could limit the period of vulnerability following HSCT/CAR‐T. The relative preservation of nAbs with ChAdOx1‐S vaccination highlights the importance of evaluating alternative platforms to mRNA vaccination within this highly vulnerable clinical cohort.
Carcerality and the elimination of Indigenous people in Canada
Authors: Barker Adam J. 
Published: November 2024

AbstractDrawing from the logic of carcerality, and refined through theories of settler colonialism, I argue in this paper the following. First, carcerality is not just a tactic of settler colonization in Canada for bodily controlling populations, but a key feature of settler colonial claims to land and territory; imposing carceral spaces on Indigenous people is a fundamental necessity for the expectations and ambitions of settler colonization, and as settler colonization in Canada is ongoing, the expansion of these carceral spaces likewise continues. Second, carceral theory can be used to analyze how Indigenous people are made to “disappear” from settler‐dominated spaces, and expose the interlocking roles of state power and social prejudice in these “eliminations.” As all kinds of frontier spaces—urban, rural, and otherwise—are assimilated into the settler colonial assemblage, Indigenous people are forced into mobility that itself is both carceral and eliminatory. Understanding carcerality as something pervasive in settler society, and not just limited to the criminal justice system, changes how we must approach decolonization.
NETosis in pulmonary pleomorphic carcinoma
Authors: Oi Hajime , Taki Tetsuro , Kuroe Takashi , Sakamoto Naoya , Sakashita Shingo , Kojima Motohiro , Sugiyama Eri , Umemura Shigeki , Sakai Tetsuya , Izumi Hiroki , Zenke Yoshitaka , Matsumoto Shingo , Yoh Kiyotaka , Ishii Makoto , Tsuboi Masahiro , Goto Koichi , Ishii Genichiro 
Published: November 2024

AbstractPulmonary pleomorphic carcinoma (PC) is a rare non‐small‐cell lung carcinoma (NSCLC) with a poor prognosis, characterized by tumor necrosis (TN). NETosis is a form of neutrophil‐specific cell death, which is morphologically characterized by prominent neutrophil infiltration and cell detritus in the necrotic foci. Seventy‐six patients with pulmonary PC who underwent complete resection were enrolled. Tumor necrosis was evaluated using digitally scanned resected specimens. The regions of NETosis were quantified using citrullinated histone H3 (citH3)‐ and myeloperoxidase‐positive regions. We examined the association between the NETosis area and the prognostic outcomes and assessed the correlation between the NETosis area and systemic inflammation. Tumor necrosis was observed in 70 patients (92%). In all the cases, the TN region was accompanied by a citH3‐positive region. The patients with high NETosis area (n = 54) had significantly shorter overall survival than those with low NETosis area (n = 16) (p = 0.013). Furthermore, a high NETosis area was an independent poor prognostic factor in the multivariate analyses. Systemic inflammatory markers, including C‐reactive protein (CRP), CRP‐to‐albumin ratio, and neutrophil‐to‐lymphocyte ratio, were significantly higher in patients with high NETosis area than in those with low NETosis area. Furthermore, the levels of these inflammatory markers were significantly decreased postsurgery. This study shows that in surgically resected pulmonary PC, patients with high NETosis areas have higher systemic inflammation and worse prognosis.
Defining Optimal Basophil Passive Sensitisation Parameters
Authors: Alvarez‐Arango Santiago , Dispenza Melanie C. , Chichester Kristin L. , MacGlashan Donald W. 
Published: November 2024

ABSTRACTBackgroundDetecting drug‐specific IgE (sIgE) is crucial for diagnosing immediate drug‐induced hypersensitivity reactions. Basophil activation tests serve as a method to determine the presence of drug‐sIgE, highlighting the importance of optimising the assay. Optimisation involves considering multiple factors to ensure sensitisation helps detect an antigen sIgE. The study investigates the complex factors influencing basophil responsiveness thresholds and aims to provide rules‐of‐thumb guidance for expected results.MethodsOpen and occupied FcεRI receptors were analysed by flow cytometry pre‐ and postdissociation of surface‐bound sIgE. Basophils were then sensitised with serial concentrations of penicillin (BPO)‐sIgE in serum or buffer and incubated for 1, 4 and 18 h with or without D2O and/or IL‐3. Basophil sensitivity was evaluated based on FcεRI receptor densities, sIgE/total IgE (tIgE) ratios, responses to BPO(21)‐HSA, and D2O and/or IL‐3 effects, with maximal responses determined using anti‐IgE human antibodies. These optimised conditions were tested with peanut‐sIgE and cat‐sIgE sera.ResultsBasophils from five donors were used. The FcεRI receptor expression initially averaged 155,000/cell (47,000–344,000/cell), with 35% (5%–79%) unoccupied, which postdissociation increased to 98% (82%–100%) unoccupied. Upon sensitisation, the average reloading with BPO‐sIgE was 39% (33%–48%). The ED50 (a measure of cellular sensitivity) was approx. 6000 BPO‐sIgE/cell, and the average maximal anti‐IgE antibody response was 58% (25%–68%). A 4‐h sensitisation at 4°C with IL‐3 pretreatment and 70% D2O allowed the detection of BPO‐sIgE/tIgE ratios as low as 0.02%–0.05% without spontaneous histamine release. Under the same conditions, responses were detected with 0.33% peanut‐sIgE and 0.1% cat‐sIgE ratios.ConclusionThis study outlines a method to assess basophil sensitisation, emphasising the minimum sIgE/tIgE ratio needed for basophil responsiveness. It considers factors like FcεRI open/unoccupied FcεRI receptors, sIgE/tIgE ratios and the effect of D2O and IL‐3. This sets a strong foundation for refining and advancing basophil activation functional assays.
Transitional implants in computer‐assisted implant surgery and fixed complete‐arch provisionalization: A retrospective case series
Authors: Pedrinaci Ignacio , Ben Dor Betty , Rousson Dominique , Lanis Alejandro , Sanz‐Esporrin Javier , Pala Kevser , Gallucci German O. , Hamilton Adam 
Published: November 2024

AbstractIntroductionUsing mini implants as transitional implants (TIs) for complete arch implant‐supported rehabilitations may overcome limitations associated with mucosa‐supported surgical guides and facilitate immediate fixed provisionalization. This study aimed to assess the success of TIs in supporting surgical guides for implant placement and fixed provisional prostheses.MethodsPatients who received TIs between 2012 and 2023 for a complete arch implant‐supported prosthesis were evaluated retrospectively. Patient demographic data, TI functionality in supporting a surgical guide and supporting a complete arch provisional prosthesis, and dates of TI placement and regular implant placement were collected. Descriptive statistics were used to determine the survival rate and success rate for TIs.ResultsTwenty‐six patients, 35 jaws, 136 TIs, and 216 regular implants were included. The survival rate of TIs was 74.26%; however, the use of TIs yielded success in 97% of jaws for supporting a surgical guide and a fixed complete‐arch provisional prosthesis throughout the complete provisional phase. An average of 4 TIs per maxilla and 3 TIs per mandible supported surgical guides. Thirty‐five provisional prostheses were placed on an average of 4 TIs in the maxilla and 3 TIs in the mandible. Thirty‐four provisional prostheses were successfully supported by TIs and regular implants until final restoration delivery. The survival of regular implants placed in conjunction with the use of TIs was 98%.ConclusionsUsing TIs to support a surgical guide and provisional prosthesis may be a predictable approach with a high success rate. All surgical guides planned to be supported on TIs were successful. Despite premature loss or replacement of TIs, this approach was able to support most provisional prostheses until the regular implants could be loaded.
A chance for countries to support Ireland's world‐leading cancer warning labels for alcohol containers
Authors: O'Brien Paula , Gleeson Deborah , Kuntsche Emmanuel , Room Robin 
Published: November 2024

AbstractIreland has regulated for all packaged alcohol products to include a health warning that states that ‘there is a link between alcohol and fatal cancers’. This warning is being opposed in the World Trade Organization by 12 member states who are raising that the warning is an unnecessary barrier to trade. The World Health Organization is supporting Ireland. Countries should not oppose Ireland's warning which is defensible from legal and public health perspectives.
Informed consent in assisted reproductive technology: Implications for pediatric clinicians
Authors: Graham Mary E. , Blee Shannon , Pentz Rebecca D. , Roebuck Emily , Hoon Alexander H. , Black Mara 
Published: November 2024

AbstractAfter conceiving through assisted reproductive technologies (ART), parents may present to their pediatrician with concerns related to their child's neurodevelopment, including whether their child's health may be related to their use of ART. Pediatricians may be unfamiliar with the ART process and what the families endured up to this point, resulting in difficulty counseling parents through these discussions. Before presentation to the pediatrician, parents have undergone extensive evaluation with reproductive endocrinologists. During counseling, the reproductive endocrinologist provides information on maternal and childhood risks associated with ART. However, in this rapidly evolving field, providing comprehensive, patient‐centered, informed consent is increasingly complex and counseling patients properly can be challenging. When parents have gone through the proper informed consent process, and when the pediatrician has an understanding of what this process entails, care of the child can be optimized. In this review, we discuss the complexities of the prenatal informed consent process that parents navigate before presenting to pediatricians. We emphasize the importance of these discussions and highlight ethical principles, as well as emotional, medical, legal, and financial stressors that parents face during ART, with the belief that this understanding will improve the care that pediatricians subsequently provide.
Structural aspects of CEACAM1 interactions
Authors: Gandhi Amit K. , Huang Yu‐Hwa , Sun Zhen‐Yu J. , Kim Walter M. , Kondo Yasuyuki , Hanley Thomas , Beauchemin Nicole , Blumberg Richard S. 
Published: November 2024

AbstractCarcinoembryonic antigen‐related cell adhesion molecule 1 (CEACAM1) is a membrane protein that plays an important role in a variety of immune and non‐immune functions. Such functions are regulated by its activity as a homophilic ligand but also through its ability to interact as a heterophilic ligand with various host proteins. These include CEACAM5, T cell immunoglobulin‐mucin like protein‐3 (TIM‐3) and, potentially, protein death protein 1 (PD‐1). Furthermore, CEACAM1 is targeted by various pathogens to allow them to invade a host and bypass an effective immune response. Clinically, CEACAM1 plays an important role in infectious diseases, autoimmunity and cancer. In this review, we describe the structural basis for CEACAM1 interactions as a homophilic and heterophilic ligand. We discuss the regulation of its monomeric, dimeric and oligomeric states in cis and trans binding as well as the consequences for eliciting downstream signalling activities. Furthermore, we explore the potential role of avidity in determining CEACAM1's activities.