bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pharmakologische und nicht-pharmakologische Behandlung der Depression im Kindes- und Jugendalter
Authors: Holtmann M. , Jarczok T. A. 
Published: September 2018

ZusammenfassungDepressive Störungen gehören zu den häufigsten psychischen Störungen im Kindes- und Jugendalter. Sie gehen mit einer starken psychosozialen Beeinträchtigung einher und sind ein Risikofaktor für affektive Störungen im Erwachsenenalter. Sowohl in der Diagnostik als auch in der Behandlung sind bei Kindern und Jugendlichen alters- und entwicklungsspezifische Aspekte zu beachten. Es wird eine selektive Übersicht über die aktuelle Datenlage zur Behandlung depressiver Störungen mit besonderem Augenmerk auf Besonderheiten des Kindes- und Jugendalters gegeben. Mittel der Wahl in der Behandlung depressiver Störungen bei Kindern und Jugendlichen sind psychotherapeutische Verfahren sowie die antidepressive Psychopharmakotherapie mit selektiven Serotoninwiederaufnahmehemmern. Unter den psychotherapeutischen Verfahren existieren die besten Wirksamkeitsnachweise für die kognitive Verhaltenstherapie. Die beste Datenlage zur Wirksamkeit von Antidepressiva existiert für den Wirkstoff Fluoxetin, welcher als einziges Antidepressivum in dieser Altersgruppe zur Behandlung depressiver Störungen zugelassen ist. Da trotz der existierenden wirksamen Behandlungsverfahren ein signifikanter Anteil von Patienten unter der Behandlung nicht remittiert, ist die Entwicklung neuer und verbesserter therapeutischer Verfahren dringend erforderlich.
Internetbezogene Störungen
Authors: Romanczuk-Seiferth N. 
Published: September 2018

ZusammenfassungDie Allgegenwärtigkeit des Internets und seiner Nutzung ist ein Phänomen unserer Zeit. Wenngleich das Internet unzählige Möglichkeiten bietet und vielfach den Alltag bereichert und erleichtert, entwickeln manche Menschen Probleme mit bestimmten Nutzungsformen des Internets und leiden unter den Folgen des häufig exzessiven Internetkonsums. Entwickelt sich eine Störung von Krankheitswert lässt sich von einer Internetbezogenen Störung sprechen. In diesem Beitrag soll überblicksartig beleuchtet werden, welchen Einfluss die Nutzung des Internets auf die Psyche haben kann und welche Formen der Internetnutzung zu einer psychischen Erkrankung führen können. Diskutiert wird, ob und inwiefern man bei exzessiver Internetnutzung von einer Abhängigkeitserkrankung sprechen kann, welche Erkenntnisse hierzu aus der aktuellen Forschung vorliegen und was die besonderen Herausforderungen in der klinischen Versorgung von Menschen mit internetbezogenen Störungen sind.
Stacked Tantalum Cones as a Method for Treating Severe Distal Femoral Bone Deficiency in Total Knee Arthroplasty
Authors: Rajgopal Ashok , Panda Inayat , Yadav Sidharth , Wakde Om 
Published: September 2018

AbstractSevere bone loss in distal femur has traditionally been managed with bulk cementing, bone graft, metal augments, trabecular metal cones, and mega prosthesis. The authors present an alternative method using a stacked configuration of two tantalum cones to manage severe distal femoral bone loss. This study aims to evaluate the mid-term outcomes and possible complications in patients treated with this novel technique. We retrospectively analyzed the prospectively maintained records of 16 knees (in 16 patients) presenting with severe distal femoral bone deficiency due to septic loosening (5), giant cell tumor (GCT; 4), periprosthetic fracture (3), aseptic loosening (3), and distal femoral comminuted fracture with severe osteoarthritis (1). A standard medial parapatellar approach was taken in all our cases followed by preparation of distal femoral bone defect and use of two bridging tantalum trabecular metal cones to fill the defect, followed by implantation of rotating hinge knee prosthesis. At an average follow-up of 57 months (4.75 years), the average Knee Society Score was 74.56 (64–87) and the mean range of motion was 97.8 (70–120) degrees. Radiologically, all 16 knees showed good osteointegration with no evidence of progressive radiolucency or loosening. Complications included two patients with superficial infection (healed with antibiotics), and one with recurrence of GCT requiring tumor megaprosthesis reconstruction. The authors concluded that the stacked configuration of cones provides additional coverage and stability with good osteointegration and found it to be particularly useful in distal femoral GCTs and fracture situations. They recommend the use of stacked cones in selected cases of severe distal femoral deficiency.
CAMSAP3 maintains neuronal polarity through regulation of microtubule stability
Authors: Pongrakhananon Varisa , Saito Hiroko , Hiver Sylvain , Abe Takaya , Shioi Go , Meng Wenxiang , Takeichi Masatoshi 
Published: September 2018

SignificanceEach neuron forms a single axon and multiple dendrites, and this configuration is important for wiring the brain. How only a single axon extends from a neuron, however, remains unknown. This study demonstrates that CAMSAP3, a protein that binds the minus-end of microtubules, preferentially localizes along axons in hippocampal neurons. Remarkably, mutations of CAMSAP3 lead to production of multiple axons in these neurons. In attempts to uncover mechanisms underlying this abnormal axon extension, the authors found that CAMSAP3-anchored microtubules escape from acetylation, a process mediated by α-tubulin acetyltransferase-1, and depletion of this enzyme abolishes abnormal axon formation in CAMSAP3 mutants. These findings reveal that CAMSAP3 controls microtubule dynamics, preventing tubulin acetylation; this mechanism is required for single-axon formation.
Simultaneous polymerization and adhesion under hypoxia in sickle cell disease
Authors: Papageorgiou Dimitrios P. , Abidi Sabia Z. , Chang Hung-Yu , Li Xuejin , Kato Gregory J. , Karniadakis George E. , Suresh Subra , Dao Ming 
Published: September 2018

Significance
Patients with sickle cell disease (SCD) suffer from painful vasoocclusive crises. Polymerization of sickle hemoglobin (HbS) in RBCs is generally considered a major contributor to such crisis events. Here, we present the simultaneous and synergistic coupling of adhesion and HbS polymerization. We show that the age of RBCs in circulation plays an important role in mediating this synergistic effect on blood rheology and clinical symptoms. In particular, the youngest RBCs exhibit unique adhesion dynamics, whereby polymerized HbS fiber bundles grow from cell surfaces to serve as sites of cytoadherence. Our molecular-level simulations show how the attachment and dissociation of molecular bonds influence adhesion dynamics. These results provide a framework that could elucidate the mechanistic basis of SCD vasoocclusive pain crises.
TOBMI: trans-omics block missing data imputation using a k-nearest neighbor weighted approach
Authors: Dong Xuesi , Lin Lijuan , Zhang Ruyang , Zhao Yang , Christiani David C , Wei Yongyue , Chen Feng 
Published: September 2018

Abstract

Motivation
Stitching together trans-omics data is a powerful approach to assess the complex mechanisms of cancer occurrence, progression and treatment. However, the integration process suffers from the ‘block missing’ phenomena when part of individuals lacks some omics data.

Results
We proposed a k-nearest neighbor (kNN) weighted imputation method for trans-omics block missing data (TOBMIkNN) to handle gene-absence individuals in RNA-seq datasets using external information obtained from DNA methylation probe datasets. Referencing to multi-hot deck, mean imputation and missing cases deletion, we assess the relative error, absolute error, inter-omics correlation structure change and variable selection.
The proposed method, TOBMIkNN reliably imputed RNA-seq data by borrowing information from DNA methylation data, and showed superiority over the other three methods in imputation error and stability of correlation structure. Our study indicates that TOBMIkNN can be used as an advisable method for trans-omics block missing data imputation.

Availability and implementation
TOBMIkNN is freely available at https://github.com/XuesiDong/TOBMI.

Supplementary information
Supplementary data are available at Bioinformatics online.
Pioneering print collector: Samuel Putnam Avery (1822–1904)
Authors: Zalewski Leanne M 
Published: September 2018

Abstract
Pioneering print collector and curator, Samuel P. Avery (1822–1904), donated a collection of 17,775 prints, including works by Cassatt, Whistler, Turner and Manet, to establish the Print Collection of the New York Public Library in 1900. Prior to his donation, Avery curated print exhibitions at the Library, Metropolitan Museum of Art, Grolier Club, and Union League Club. Through an examination of Avery’s persistent efforts to exhibit exemplary prints in museum and gallery settings – including an unusual collection of prints by women – this article provides evidence that Avery’s ground-breaking curatorial efforts led to the institutionalization of print display in New York.
Longitudinal and Reciprocal Relationships Between Psychological Well-Being and Smoking
Authors: Lappan Sara , Thorne Christopher B , Long Dustin , Hendricks Peter S 
Published: September 2018

Abstract

Introduction
Smoking cessation treatments currently succeed at a rate of approximately 20%–30%, underscoring the importance of exploring factors that might increase intervention effectiveness. Although negative affect has been studied extensively in relation to smoking cessation, psychological well-being (PWB; eg, life satisfaction, optimism, positive affect, purpose in life) has received little attention. This study tested longitudinal and reciprocal relationships between PWB and smoking status in older adults.

Methods
Panel data were obtained from the biennial, longitudinal Health and Retirement Study. Using structural equation modeling, we developed cross-lagged models to examine the relationships of PWB in 2006 with smoking status in 2010 and of smoking status in 2006 with PWB in 2010 while controlling for covariates (Ns = 2939–4230, 55% women, 89% white, mean age = 64 years, mean years of education = 13, 25% smokers in 2006 and 21% smokers in 2010). Separate cross-lagged models were developed for each of the PWB variables: life satisfaction, optimism, positive affect, and purpose in life.

Results
Greater life satisfaction (standardized path coefficient = −0.04), optimism (standardized path coefficient = −0.07), and positive affect (standardized path coefficient = −0.08) in 2006 predicted a reduced likelihood of smoking in 2010. Being a smoker in 2006 predicted lower life satisfaction (standardized path coefficient = −0.25), optimism (standardized path coefficient = −0.10), positive affect (standardized path coefficient = −0.10), and purpose in life (standardized path coefficient = −0.13) in 2010.

Conclusions
Findings warrant further exploration of the relationships between PWB and smoking, and support the incorporation of PWB-boosting components into existing treatments.

Implications
Given the relatively low success rate of current smoking cessation treatments, the present results suggest that increasing PWB might promote abstinence and therefore warrant consideration as a focus of future cessation treatment research. Moreover, these results suggest that smoking might inhibit PWB, illuminating a negative consequence of smoking not previously identified. Helping smokers increase their PWB may benefit them beyond promoting cessation and contribute to a flourishing society. These results warrant further investigation of PWB and smoking, and support the continued evaluation of PWB-boosting components in smoking cessation treatments.
Mitigating the Effect of Pain Severity on Activity and Disability in Patients with Chronic Pain: The Crucial Context of Acceptance
Authors: Kanzler Kathryn E , Pugh Jacqueline A , McGeary Donald D , Hale Willie J , Mathias Charles W , Kilpela Lisa S , Karns-Wright Tara E , Robinson Patricia J , Dixon Sara A , Bryan Craig J , Moring John C , McCracken Lance M 
Published: September 2018

AbstractObjectiveThe purpose of this study was to examine the effect of pain severity on activity levels and physical disability in the context of high pain acceptance. We hypothesized that pain acceptance moderates the effect of pain severity on general activity and physical disability, such that at higher levels of acceptance, the deleterious effect of pain is mitigated.MethodsTwo hundred seven patients with chronic pain were recruited from three clinics in a large southwestern military treatment facility. Participants completed an anonymous self-report battery of standardized measures, including the Chronic Pain Acceptance Questionnaire, modified Oswestry Disability Index, and Pain Severity and General Activity subscales of the West Haven-Yale Multidimensional Pain Inventory.ResultsChronic pain acceptance was found to significantly moderate relations between pain severity and general activity (b  =  0.0061, t(198) = 2.75, P = 0.007, 95% confidence interval [CI] = 0.002 to 0.011) and pain severity and disability (b  =  0.036, t(193) = –2.564, P = 0.011, 95% CI = –0.063 to –0.008). In the context of higher acceptance, the negative effect of pain on activity and disability appeared reduced. Conversely, in the context of low acceptance, the effect of pain on disability appeared accentuated at all levels of pain severity.ConclusionsHigher acceptance mitigated both activity level and disability in a military-affiliated clinical sample of patients with chronic pain. Results further establish the role of acceptance in relation to functioning in a unique sample of people with chronic pain. These findings have implications for understanding and enhancing functioning in chronic pain populations.
Individualized Medication of Voriconazole: A Practice Guideline of the Division of Therapeutic Drug Monitoring, Chinese Pharmacological Society
Authors: Chen Ken , Zhang Xianglin , Ke Xiaoyan , Du Guanhua , Yang Kehu , Zhai Suodi ,   on behalf of the Guideline Steering Committee, the Guideline Consensus Panel, and the Guideline Development Group
Published: September 2018

Background:
Voriconazole (VRZ) is a second-generation triazole antifungal agent with broad-spectrum activity. It is available in both intravenous and oral formulations, and is primarily indicated for treating invasive aspergillosis. The most commonly used dose for adults is 4 mg/kg or 200 mg twice daily. VRZ presents nonlinear pharmacokinetics in adults, whereas drug–drug interactions and cytochrome P450 2C19 (CYP2C19) polymorphism are of great concern for VRZ. Because the liquid chromatography method has been widely used for measuring VRZ blood concentration, and target VRZ blood concentration has been recommended in some guidelines regarding efficacy and safety, therapeutic drug monitoring is considered as a useful tool for VRZ-individualized medication. Also, the CYP2C19 genotype test is available for guiding relevant drugs use in some health care facilities. Our objective was to develop an evidence-based practice guideline for VRZ-individualized medication.

Methods:
We followed the latest guideline definition from the Institute of Medicine and referred to the World Health Organization handbook for guideline development. The guideline was initially registered in the International Practice Guidelines Registry Platform (IPGRP-2015CN001). The guideline is, in principle, targeted at all Chinese health care providers. The quality of evidence and strength of the recommendations were assessed using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) method.

Results:
Twenty-six recommendations were formulated regarding therapeutic drug monitoring, special groups of patients, drug safety, off-indication use, and drug–drug interactions. Of them, 12 were strong recommendations. Most quality of evidence was low, very low, or expert opinions.

Conclusions:
We developed an evidence-based practice guideline for VRZ-individualized medication, which provided comprehensive and practical recommendations for health care providers. The development of the guideline exposed several research gaps to improve VRZ use.
Functional brain activity during motor control and pain processing in chronic jaw pain
Authors: Roy Arnab , Wang Wei-en , Ho Rachel L.M. , Ribeiro-Dasilva Margarete C. , Fillingim Roger B. , Coombes Stephen A. 
Published: September 2018

AbstractChanges in brain function in chronic pain have been studied using paradigms that deliver acute pain-eliciting stimuli or assess the brain at rest. Although motor disability accompanies many chronic pain conditions, few studies have directly assessed brain activity during motor function in individuals with chronic pain. Using chronic jaw pain as a model, we assessed brain activity during a precisely controlled grip force task and during a precisely controlled pain-eliciting stimulus on the forearm. We used multivariate analyses to identify regions across the brain whose activity together best separated the groups. We report 2 novel findings. First, although the parameters of grip force production were similar between the groups, the functional activity in regions including the prefrontal cortex, insula, and thalamus best separated the groups. Second, although stimulus intensity and pain perception were similar between the groups, functional activity in brain regions including the dorsal lateral prefrontal cortex, rostral ventral premotor cortex, and inferior parietal lobule best separated the groups. Our observations suggest that chronic jaw pain is associated with changes in how the brain processes motor and pain-related information even when the effector producing the force or experiencing the pain-eliciting stimulus is distant from the jaw. We also demonstrate that motor tasks and multivariate analyses offer alternative approaches for studying brain function in chronic jaw pain.
Reduced Cancer Survival Among Adults With HIV and AIDS-Defining Illnesses Despite No Difference in Cancer Stage at Diagnosis
Authors: Grover Surbhi , Desir Fidel , Jing Yuezhou , Bhatia Rohini K. , Trifiletti Daniel M. , Swisher-McClure Samuel , Kobie Julie , Moore Richard D. , Rabkin Charles S. , Silverberg Michael J. , Salters Kate , Mathews William Christopher , Gill Michael John , Thorne Jennifer E. , Castilho Jessica , Kitahata Mari M. , Justice Amy , Horberg Michael A. , Achenbach Chad J. , Mayor Angel M. , Althoff Keri N. ,   for the North American AIDS Cohort Collaboration on Research and Design
Published: September 2018

Background:
It is not known whether immune dysfunction is associated with increased risk of death after cancer diagnosis in persons with HIV (PWH). AIDS-defining illness (ADI) can signal significant immunosuppression. Our objective was to determine differences in cancer stage and mortality rates in PWH with and without history of ADI.

Methods:
PWH with anal, oropharynx, cervical, lung cancers, or Hodgkin lymphoma diagnoses from January 2000 to December 2009 in the North American AIDS Cohort Collaboration on Research and Design were included.

Results:
Among 81,865 PWH, 814 had diagnoses included in the study; 341 (39%) had a history of ADI at time of cancer diagnosis. For each cancer type, stage at diagnosis did not differ by ADI (P > 0.05). Mortality and survival estimates for cervical cancer were limited by n = 5 diagnoses. Adjusted mortality rate ratios showed a 30%–70% increase in mortality among those with ADI for all cancer diagnoses, although only lung cancer was statistically significant. Survival after lung cancer diagnosis was poorer in PWH with ADI vs. without (P = 0.0001); the probability of survival was also poorer in those with ADI at, or before other cancers although not statistically significant.

Conclusions:
PWH with a history of ADI at lung cancer diagnosis had higher mortality and poorer survival after diagnosis compared to those without. Although not statistically significant, the findings of increased mortality and decreased survival among those with ADI (vs. without) were consistent for all other cancers, suggesting the need for further investigations into the role of HIV-related immune suppression and cancer outcomes.
Triphasic Waves and Encephalopathy in the Setting of Pregabalin Toxicity
Authors: Anand Pria , Kaplan Peter Wolfe 
Published: September 2018

Summary:
EEG triphasic waves are usually seen in the setting of metabolic encephalopathies, but may also occur secondary to medication toxicity. There are few reports of medications causing continuous triphasic waves, and only rare reports in the literature show an association between these discharges and pregabalin toxicity. Here, we describe triphasic waves in a patient with underlying white matter lesions, as well as pregabalin toxicity, secondary to renal insufficiency. Patients with renal or hepatic failure presenting with triphasic waves and confusion pose a diagnostic challenge in determining whether the etiology of their encephalopathy is purely metabolic or whether it results from impaired medication clearance and subsequent toxicity. In this patient, discontinuing pregabalin improved her EEG despite the ongoing renal insufficiency, confirming pregabalin toxicity as an etiology of triphasic waves and encephalopathy.
Post-Hurricane Vital Statistics Expose Fragility of Puerto Rico’s Health System
Authors: Acosta Rolando J. , Irizarry Rafael A. 
Published: September 2018

AbstractImportanceHurricane Maria made landfall in Puerto Rico on September 20, 2017. As recently as May of this year (2018), the official death count was 64. After a study describing a household survey reported a much higher death count estimate, as well as evidence of population displacement, extensive loss of services, and a prolonged death rate the government released death registry data. These newly released data will permit a better understanding of the effects of this hurricane.ObjectiveProvide a detailed description of the effects on mortality of Hurricane Maria and compare to other hurricanes.DesignWe fit a statistical model to mortality data that accounts for seasonal and non-hurricane related yearly effects. We then estimated the deviation from the expected death rate as a function of time.SettingWe fit this model to 1985-2018 Puerto Rico daily data, which includes the dates of hurricanes Hugo, Georges, and Maria, 2015-2018 Florida daily data, which includes the dates of Hurricane Irma, 2002-2004 Louisiana monthly data, which includes the date of Hurricane Katrina, and 2000-2016 New Jersey monthly data, which includes the date of Hurricane Sandy.ResultsWe find a prolonged increase in death rate after Maria and Katrina, lasting at least 207 and 125 days, resulting in excess deaths estimates of 3,400 (95% CI, 3,100-3,700), and 1,800 (95% CI, 1,600-2100) respectively, showing that Maria had a more long term damaging impact. Surprisingly, we also find that in 1998, Georges had a comparable impact to Katrina’s with a prolonged increase of 106 days resulting in 1,400 (95% CI, 1,200-1,700) excess deaths. For Hurricane Maria, we find sharp increases in a small number of causes of deaths, including diseases of the circulatory, endocrine and respiratory system, as well as bacterial infections and suicides.Conclusion and RelevanceOur analysis suggests that since at least 1998, Puerto Rico’s health system has been in a precarious state. Without a substantial intervention, it appears that if hit with another strong hurricane, Puerto Ricans will suffer the unnecessary death of hundreds of its citizens.Key PointsQuestion: How does the effect of Hurricane Maria on mortality in Puerto Rico compare to the effect of other hurricanes in Puerto Rico and other United States jurisdictions?Findings: We estimate about 3,000 excess deaths after Maria, a higher toll than Katrina. Only other comparable effect was after Georges, also in Puerto Rico. For Georges and Maria, we observe a prolonged death rate increase of more than 10% lasting several months. The causes of death that increased after Maria are consistent with a collapsed health systemMeaning: Puerto Rico’s health system does not appear to be ready to withstand another strong hurricane.