bluuebunny/crossref_metadata_2025_split huggingface dataset:
Capnocytophaga canimorsus Periprosthetic Joint Infection in an Immunocompetent Patient: A Case Report
Authors: Kelly Blane C. , Constantinescu David S. , Foster William 
Published: April 2019

Introduction: A periprosthetic joint infection (PJI) is a potentially devastating complication following an arthroplasty procedure. There are many organisms that commonly cause this complication; in this case report, we will discuss a PJI caused by an unusual bacteria found in the mouths of domestic pets. Objective: To present a case report of a patient with a periprosthetic hip infection from Capnocytophaga canimorsus and review the literature. Methods: We present a case of C canimorsus PJI in an immunocompetent woman who had undergone a total hip arthroplasty. The patient was doing well postoperatively for many years until she was bitten on the foot by a domestic canine. Patient diagnosed using Musculoskeletal Infection Society criteria, then treated with explant of the hip prosthesis, irrigation and debridement, placement of an antibiotic cement spacer, and a 6-week course of intravenous antibiotics. Results: Unfortunately, while awaiting replant, this patient had a massive myocardial infarction and died. Discussion: Current literature suggests treating canine bites with amoxicillinas well as a discussion with patients pre-/postoperatively from a lower extremity arthroplasty specialist. Conclusion: Capnocytophaga canimorsus is a rare cause of infection, even more unusual in an immunocompetent patient. This study highlights the importance of considering C canimorsus as a cause of PJI, regardless of the immunologic status of the patient.
Opportunities and Challenges for Regional Economic Integration in the Indian Ocean
Authors: Wignaraja Ganeshan , Collins Adam , Kannangara Pabasara 
Published: April 2019

This article examines increasing regional economic integration in the Indian Ocean, along with the region’s rising importance in the global economy and outlines the challenges to greater regional integration. It finds that the strategically located Indian Ocean economy has become an increasingly important part of the global economy in the past two decades and has become more integrated within itself. Forecasts suggest that the Indian Ocean economy will likely account for around a fifth of global GDP by 2025 and its GDP per capita is expected to almost double. However, realising this outlook will depend on tackling several pressing challenges to regional integration, including improving port quality and logistics, lowering barriers to trade and investment, narrowing development gaps, and strengthening the regional economic governance. Tackling these challenges requires a combination of coherent national and regional policy measures. JEL Codes: F150, F410, F550
Prospective Clinical Validation of the InVisionFirst-Lung Circulating Tumor DNA Assay for Molecular Profiling of Patients With Advanced Nonsquamous Non–Small-Cell Lung Cancer
Authors: Pritchett Michael A. , Camidge D. Ross , Patel Manu , Khatri Jamil , Boniol Steven , Friedman Elke K. , Khomani Abderrahim , Dalia Samir , Baker-Neblett Katherine , Plagnol Vincent , Howarth Karen D. , Jones Gregory R. , Rosenfeld Nitzan , Morris Clive D. , Govindan Ramaswamy 
Published: April 2019

PURPOSE Guidelines advocate molecular profiling in the evaluation of advanced non–small-cell lung cancer (NSCLC) and support the use of plasma circulating tumor DNA (ctDNA)-based profiling for patients with insufficient tissue. Thorough prospective clinical validation studies of next-generation sequencing (NGS)-based ctDNA assays are lacking. We report the multicentered prospective clinical validation of the InVision ctDNA assay in patients with advanced untreated NSCLC. METHODS A total of 264 patients with untreated advanced NSCLC were prospectively recruited, and their plasma was analyzed using a ctDNA NGS assay for detection of genomic alterations in 36 commonly mutated genes. Tumor tissue was available in 178 patients for molecular profiling for comparison with plasma profiling. The remaining 86 patients were included to compare ctDNA profiles in patients with and without tissue for profiling. RESULTS Concordance of InVisionFirst with matched tissue profiling was 97.8%, with 82.9% positive predictive value, 98.5% negative predictive value, 70.6% sensitivity, and 99.2% specificity. Considering specific alterations in eight genes that most influence patient management, the positive predictive value was 97.8%, with 97.1% negative predictive value, 73.9% sensitivity, and 99.8% specificity. Across the entire study, 48 patients with actionable alterations were identified by ctDNA testing compared with only 38 by tissue testing. ctDNA NGS reported either an actionable alteration or an alteration generally considered mutually exclusive for such actionable changes in 53% of patients. CONCLUSION The liquid biopsy NGS assay demonstrated excellent concordance with tissue profiling in this multicenter, prospective, clinical validation study, with sensitivity and specificity equivalent to Food and Drug Administration–approved single-gene ctDNA assays. The use of plasma-based molecular profiling using NGS led to the detection of 26% more actionable alterations compared with standard-of-care tissue testing in this study.
The Liver as an Endocrine Organ—Linking NAFLD and Insulin Resistance
Authors: Watt Matthew J , Miotto Paula M , De Nardo William , Montgomery Magdalene K 
Published: April 2019

AbstractThe liver is a dynamic organ that plays critical roles in many physiological processes, including the regulation of systemic glucose and lipid metabolism. Dysfunctional hepatic lipid metabolism is a cause of nonalcoholic fatty liver disease (NAFLD), the most common chronic liver disorder worldwide, and is closely associated with insulin resistance and type 2 diabetes. Through the use of advanced mass spectrometry “omics” approaches and detailed experimentation in cells, mice, and humans, we now understand that the liver secretes a wide array of proteins, metabolites, and noncoding RNAs (miRNAs) and that many of these secreted factors exert powerful effects on metabolic processes both in the liver and in peripheral tissues. In this review, we summarize the rapidly evolving field of “hepatokine” biology with a particular focus on delineating previously unappreciated communication between the liver and other tissues in the body. We describe the NAFLD-induced changes in secretion of liver proteins, lipids, other metabolites, and miRNAs, and how these molecules alter metabolism in liver, muscle, adipose tissue, and pancreas to induce insulin resistance. We also synthesize the limited information that indicates that extracellular vesicles, and in particular exosomes, may be an important mechanism for intertissue communication in normal physiology and in promoting metabolic dysregulation in NAFLD.
Dose-Dependent Effects of Exercise and Diet on Insulin Sensitivity and Secretion
Authors: DING CHERLYN , CHOOI YU CHUNG , CHAN ZHILING , LO JEZEBEL , CHOO JOHN , DING BENJAMIN TZE KEONG , LEOW MELVIN K.-S. , MAGKOS FAIDON 
Published: April 2019

ABSTRACT

Purpose
A single bout of aerobic exercise increases insulin sensitivity the next day. The effects of exercise on insulin secretion, the role of exercise-induced energy deficit, and possible dose–response relationships are not well understood. This study aimed to evaluate insulin sensitivity and insulin secretion after progressively greater negative energy balance induced by exercise or diet.

Methods
Acute energy deficits (20% or 40% of weight maintenance needs) were induced by a single day of aerobic exercise (cycling at moderate intensity, n = 13) or dietary restriction (n = 19) in healthy men and women (age, 26 ± 2 yr; body mass index, 21.8 ± 0.5 kg·m−2). Intravenous glucose tolerance tests in conjunction with minimal modeling were performed the next morning, and blood samples were collected for 3 h to measure glucose and insulin concentrations.

Results
Insulin sensitivity increased linearly after exercise-induced energy deficits (P = 0.007) but did not change after equivalent diet-induced energy deficits (P = 0.673). Acute insulin response decreased after both exercise (P < 0.001) and dietary restriction (P = 0.005). The disposition index and glucose effectiveness were not affected by exercise (P = 0.138 and 0.808, respectively), but both decreased after 40% dietary restriction (P = 0.048 and 0.002, respectively).

Conclusions
These results indicate that insulin sensitivity and insulin secretion are related to exercise energy expenditure, albeit in a different fashion (insulin sensitivity increases linearly, whereas insulin secretion drops to a nadir with a low exercise dose and does not decrease further). These changes cannot be replicated by equivalent energy deficits induced by dietary restriction, suggesting that exercise and diet have different effects on the mechanisms regulating glucose homeostasis. Trial Registration: ClinicalTrials.gov, NCT03264001.
Meniscus allograft transplantation: indications, techniques and outcomes
Authors: Figueroa Francisco , Figueroa David , Calvo Rafael , Vaisman Alex , Espregueira-Mendes João 
Published: April 2019

New indications for meniscal allograft transplantation (MAT) are being added, but the general expert opinion is that it is still a procedure reserved for symptomatic meniscal loss. Lateral MAT has better clinical outcomes and less failure risk compared to medial MAT. Ideal conditions (low-grade chondral lesions) make MAT a more survivable and successful procedure. Meniscal extrusion after MAT is common and does not seem to alter results. Midterm survivorship of a MAT is reported to be 85–90%, while long-term survivorship decreases to 50–70% depending on chondral status and concomitant procedures. Even if the procedure is a success, there are high possibilities of not being able to resume sports activities. Cite this article: EFORT Open Rev 2019;4:115-120. DOI: 10.1302/2058-5241.4.180052
Towards an Open Access publication workflow for monographs for university presses
Authors: Schrader Antonia , Grossmann Alexander , Reiche Michael , Böhm David 
Published: April 2019

A first draft of an media-neutral as well as both cost-effective and personnel-efficient publications workflow for Open Access (OA) monograph publishing at university presses is presented. The workflow has been developed as a result of the research project
Open-Access-Hochschulverlagat the Leipzig University of Applied Sciences, Germany. The aim of the project is to develop a sustainable and adoptable workflow to enable universities to publish their publications as OA and printed books simultaneously in a state-of-the-art way and without any restrictions regarding the license, the variety of formats, print run etc.
Up to now, we have defined 20 main processes with up to 12 sub-processes which a university press has to consider when publishing OA books state-of-the-art. These processes have been shown on the poster.
The arrangement and the arrows between the processes indicate in which order the processes should be ideally organised by the university presses. Since any university may adapt that workflow individually, it includes several possible ways by which an OA book can be published (see process 1 or 3 at the poster). The visualisation of the publication workflow represents only a part of the results of our research project. In addition detailed descriptions for each process have been created, which explain a certain process in depth, e.g. who is responsible for it, what time it takes and what it may cost to complete the process. These detailed descriptions will be published elsewhere.
A voice based text mail system for visually impaired
Authors: Mary Belinda M.J Carmel , N Rupavathy , N.R Mahalakshmi 
Published: April 2019

To develop a voice primarily based email system that will facilitate visually impaired individuals to access email in a problem free manner. Together with providing usage of mail services simply and with efficiency, the system also will cut back the psychological feature work that must be unremarkably taken by the visually impaired to recollect and sort characters using the normal Braille keyboards, which are accessible to them. The graphical user interface of this method has been evaluated against the interface of the traditionally accessible mail system. Not only for visually impaired, but also for people who are illiterate might have the benefit of this technique. The foremost crucial facet which will be thought of developing this technique is that the users of this technique does not have any basic information regarding the keyboard shortcuts used or wherever the keys are used for. All functions to be utilized in this technique are supposed to be easy mouse click operations creating the system very user friendly. This application proposes an android application, designed specifically for visually impaired individuals. This application provides a voice primarily based mailing service which provides them to browse and send mail on their own, without any guidance. The users ought to use certain keywords which can perform certain actions for e.g. Read, Send, Compose Mail, Address Book etc. This EMAIL system is utilized by a visually handicapped person to access mails easily and with efficiency. Therefore reliance of visually impaired on others for his or her own activities associated with mail are often reduced.
Factors Affecting Writing Skill Using Computer Assisted Test (CAT) in Junior High School Students
Authors: Suhita Raheni , J. Waluyo Herman , Setiawan Budhi 
Published: April 2019

This study aimed to determine the factors affecting writing skill quality and the level of their contribution to help language teachers to formulate more effective strategies using CAT to enhance writing skill. The correlating factors discussed in this research were students’ reading comprehension skill, vocabulary mastery, and attitude toward language. The study applied quantitative approach with simple and multiple correlation and regression techniques. The samples of the study were 100 students taken using stratified random sampling technique from a population of 2000 junior high school students in Surakarta City. The data were collected using multiple choice test for students’ reading comprehension skills and vocabulary mastery, writing assignments, and questionnaires for their attitudes toward the Indonesian language. The findings showed that there are positive correlations between the independent variables, either individually or simultaneously, with writing skill. The individual contribution levels is 44.75% of reading comprehension skill, 27.70% of vocabulary mastery, and 28.5% of attitude toward language. As for the simultaneous correlation of the three determining factors make up to 45.16%. contribution level to writing skill quality. Thus it can be concluded that reading comprehension has the most contribution to writing skill compared to vocabulary mastery and attitude toward language. The identified levels of contribution can be taken into consideration in formulating teaching strategies and materials to enhance writing skill quality.
A Study on Data Security In Fog Computing
Authors: S.Apirajitha P 
Published: April 2019

During the years, Cloud Computing is a popular paradigm which provide access to configurable resources on devices at any time,with on demand. Cloud Computing provides many benefits to enterprises by reducing the cost and allowing them to concentrate on their core business. Apart from this , the Development of Internet of Things came into existence, where the cloud divulge a long distance between users and its environment. Cloud Computing is also referred as heavy computing and dense form of computing power. In Spite of this a new computing has been proposed called Fog Computing also known as Fogging, which overcomes the problem of cloud. Fog computing which majority supports the concepts of Internet of Things(IoT), where many IoT devices are used by users on daily basis which are connected to each other. Fog Computing is also an extended version of cloud computing.
Synthesis and Characterization of Super Paramagnetic Magnetite Nanoparticles for Drug Delivery Application
Authors: BALAJ D , SARALA RUBI C , G. RENGANATHAN N 
Published: April 2019

Attractive nanoparticles have been broadly considered on account of their potential applications as complexity operators in attractive reverberation imaging (MRI) of tumors, cell and DNA partition, attractively guided medication conveyance, tumor hyperthermia. Among the attractive oxides, magnetite nanoparticles are most appropriate because of their low danger and great attractive properties which may be used in drug delivery. Magnetite nanoparticles were synthesized using FeCl3 and FeSO4 as precursors and characterized for size and shape using non-contact AFM. The formation of magnetite was confirmed by XRD pattern. The elemental composition of the obtained phase was determined using EDAX. In this work, we are aiming to develop drug loaded biopolymer Magnetite nanoparticles for biomedical application. Our main objective is to synthesize and characterize Magnetite (Fe3O4) nanoparticles.
Active Database System Approach and Rule Based in the Development of Academic Information System
Authors: Miftakul Amin M , Maseleno Andino , K Shankar , Perumal Eswaran , M Vidhyavathi R , SK Lakshmanaprabu 
Published: April 2019

Active database system is a database system which is capable of generating a certain action automatically if it detects an event that meets certain conditions. The existence of Event Condition Action (ECA) rules and functional components such as triggers, stored procedures, and stored functions that are owned by active database system make the database system has the ability to automatically monitor input and output data. Separation of ECA rules components in the database with the application program will also facilitate the development of information systems. This research applies active database system in academic information system, so that academic business rules can be planted in database software and be able to produce the right solution automatically. The addition of active database system components to the database software makes procedures such as subject distribution, study plans, academic leave, values, thesis defense and other processes can be monitored by the system automatically. This can be done because between applications and databases use the model driven approach parameters to communicate with each other. The results of this research prove that a database is not only has function as a container of data, but can control the information system actively, this is caused by the logic of programs that are generally planted in the application layer that can be moved and planted in the database software.
Grounded Impedance Simulator Topologies Employing Minimum Passive Elements
Authors: Faseehuddin Mohammad , Sampe Jahariah , Hamid Md Ali Sawal 
Published: April 2019

In this research three new grounded inductance simulators (GIS) are proposed. In addition, frequency dependent negative resistor (FDNR) and grounded capacitor (GC) simulators are also developed. The voltage differencing current conveyor (VDCC) is utilized in the design. All the developed simulator circuits need a single active block and only two grounded passive components. All the designed simulator circuits are perfectly tunable and did not suffer from passive component matching constraints. To demonstrate the performance of the inductor, FDNR and GC circuits they are employed in designing current mode parallel RLC multifunction filter, low pass third order Butterworth filter and RLC resonance circuits. The VDCC is designed in 0.18μm CMOS technology parameters from TSMC and simulated in P-Spice software to prove the theoretical predictions.
On Distributed Reflexive Complex Mechanisms of Decision-making in a Transportation System of a Smart city
Authors: Fedyanin Denis , Vershinin Yuri 
Published: April 2019

We describe distributed reflexive complex mechanisms of decision-making in a SMART city. These complex mechanisms are a cognitive self-organizing decision support system for development governance. These mechanisms utilize local information from all nearby sensors of city sensors on buildings, sensors on other cars, sensors on pedestrians and some additional information. We describe the way to a new level of safety of citizens by additional vision and automated reasoning. It provide transparency in Augmented Reality Devices by virtually eliminating obstacles e.g. buildings. The problem is that development of a city is a process so people still have to make suggestions and now these suggestions are about awareness of other agents. Distributed reflexive complex mechanisms can assist and support their decisions in solving these problems.
Development of Non-Character Player Using Self-Learning Algorithm for Artificial Intelligent Games
Authors: A. Noryushan M , Zamin N , A. Rahim H , A. Sahari M , I. Hassan N , M. Fauzee Z 
Published: April 2019

In most of video games, the Non-Playing Character (NPC) behavior and movement are usually scripted. Players who have exploited the NPCs weaknesses will be able to beat them easily and there will be no freshness in player experiences. However, if the character can adapt and learn from the environment, it will be more interactive since players need to find new weaknesses to exploit. In this project, an agent that can learn by itself in the game which is introduced. This ongoing project investigates and compares the available self-learning algorithms used in game development and will be implemented as the intelligent agent. The Fourth Industrial Revolution (IR 4.0) has the potential to raise global income levels and improve the quality of life through Artificial Intelligence (AI) programs. AI has made possible new products and services that increase the efficiency and pleasure of our personal lives such as dynamic games that can learn from its environment.