bluuebunny/crossref_metadata_2025_split huggingface dataset:
MULHERES NEGRAS NÃO FORAM FEITAS PARA CARREGAR LIVROS: TENSIONAMENTO E RESPOSTA SOCIAL EM REDE NA FEIRA PAN-AMAZÔNICA DO LIVRO NO PARÁ
Authors: Brito Rosaly de Seixas , Esteves Lorena Cruz , Ventura Jússia Carvalho da Silva 
Published: September 2019

Este trabalho analisa a repercussão social do cartaz do “Salão do Livro da Região Sul e Sudeste do Pará”, evento da Feira Pan-Amazônica do Livro de 2018, para compreender como o processo de resposta social (BRAGA, 2006) impôs uma mudança institucional por parte da Secretaria de Cultura do Estado. O país homenageado foi a Colômbia e a peça de divulgação destacava uma mulher negra carregando livros na cabeça, representação das palenqueras. O fato gerou repercussão nas redes sociais e na mídia local e nacional. Os protestos voltaram-se contra a reiteração de uma imagem que inferioriza as mulheres negras, reproduzindo colonialidades de gênero, poder e saber. O corpuscompõe-se de postagens no Facebooke de matérias jornalísticas veiculadas em abril de 2018. Duas técnicas metodológicas foram usadas: a netnografia (RECUERO, 2012; KOZINETS, 2014) e a aplicação de um questionário online, por meio do Facebook e Whatsapp.
A PRODUÇÃO CIENTÍFICA BRASILEIRA NA WEB OF SCIENCE (2017-2019): ENTRE O DISCURSO POLÍTICO E OS ESTUDOS MÉTRICOS DE INFORMAÇÃO
Authors: Bufrem Leilah Santiago , Nascimento Bruna S. do 
Published: September 2019

Apresenta as características da produção científica brasileira representada na Web of Science (WOS) como exemplo ilustrativo resultante das relações entre elementos estruturais e conjunturais na dinâmica das políticas científicas adotadas pelo governo em relação à ciência brasileira. Subsidia metodologicamente o estudo relacional do campo científico no Brasil, optando pela utilização da análise de conjuntura em prol da compreensão da diversidade dos elementos empíricos representativos da produção científica brasileira indexada na WOS, entre os anos de 2017 e 2019. Analisa como as exigências produtivistas das agências de fomento se intensificaram nas últimas décadas e se fazem presentes nas discussões em diferentes campos do saber, argumentando que as rígidas práticas empregadas no campo da Ciência justificam estudos sobre as correlações e interações em prol da compreensão e do respeito ao campo e às instituições nas quais se alicerça. Apresenta como resultados, a partir dos dados empíricos, a formação de cinco grandes clusters entre os quais se destaca a Universidade de São Paulo (USP) como nó central e polo de produção científica nacional. Reconhece que, embora a base de dados escolhida, represente a big science internacionalizada e centralizada na produção oriunda dos Estados Unidos e de países europeus, a representatividade brasileira é relevante, especialmente se consideradas as temáticas de interesse endêmico como as doenças tropicais e que são pesquisadas, predominantemente, pelo Brasil e por países abaixo da linha do equador.
COMPETÊNCIA DISCURSIVA: UM CASO ESPECIAL DE COMPETÊNCIA COMUNICATIVA
Authors: Lima Clóvis Ricardo Montenegro de , Günther Helen Fischer , Maia Mariangela Rebelo 
Published: September 2019

Neste artigo quer-se delinear o conceito de competência discursiva como um caso especial de competência comunicativa, tanto quanto o Discurso é um caso especial de agir comunicativo. Parte-se da discussão de competência dentro do processo de aprendizagem e do desenvolvimento moral, e dentro dela a competência linguística e a competência comunicativa. Faz-se o desenvolvimento da noção de competência discursiva como capacidade de argumentar racionalmente, de reconhecer o outro e os seus argumentos e de fazer acordos em torno do melhor argumento. Inclui também a capacidade de universalizar o processo argumentativo. O desenvolvimento da competência discursiva está vinculado ao desenvolvimento moral de indivíduos, grupos sociais e sociedade. Conclui-se que existe sim uma competência discursiva e que esta pode ser desenvolvida, não apenas como habilidade técnica, mas também como desenvolvimento moral.
EFFECTS OF VISCOELASTIC PROPERTIES AND HYDRATION KINETIC ON DRUG RELEASE FROM THE TABLET OF DICLOFENAC SODIUM BASED ON POLY (SODIUM ACRYLATE)-GRAFTED-GELLAN MATRIX
Authors: Nandi Gouranga 
Published: September 2019

Investigation of the effects of viscoelasticity and hydration kinetic on the drug release behavior from the poly (sodium acrylate)-grafted-gellan matrix (PSAc-g-GG) was the main objective of this study. At first, poly (acrylic acid)-grafted-gellan was treated with 0.05M NaOH to obtain poly (sodium acrylate)-grafted-gellan followed by its purification and subsequent lyophilicity study and viscoelastic study on PSAc-g-GG with different degree of grafting. The study revealed that the degree of grafting greatly affects the viscoelastic and rheologic characteristics of the copolymer, which further affect the drug release profile from the polymeric matrix. The copolymer with highest grafting (626.3%) exhibited much higher starting % strain (17.79%), stress (53.7 Pa) for structural breakdown at Gꞌ = Gꞌꞌ (214.4 Pa), higher storage modulus (G’), much greater values of complex viscosity (11.5 Pa.s) and cross-over point (Gꞌ = Gꞌꞌ =271.65 Pa) compared to that of the batch of copolymer with lower grafting. The water uptake index (%WE) was found to be directly proportional to the percentage grafting (%G), whereas the batches with higher grafting revealed lower initial swelling rate representing its inversely proportional relation to %grafting in case of 0.1N HCl acid. Equilibrium swelling and hydration were also found to be proportional to % grafting. The similar effect was observed in phosphate buffer solution (pH 6.8) with an exception that the degree of the swelling parameters obtained from phosphate buffer was very much greater compared to that found in 0.1N HCl. PSAc-g-GG exhibited extended drug release over a period of 10 hours with the drug release mechanism based on Case-1 Fickian diffusion or square root of time kinetic. The study also exhibited the usefulness of viscoelastic and swelling study in order to identify the effects of the degree of grafting on the drug release.
Evaluation of Antiulcerogenic Activity of Clerodendron Infortunatum Extract on Albino Rat Gastric Ulceration
Authors: Kumar Arun , Shukla Rahul , Chaudhary Anurag 
Published: September 2019

Clerodendron infortunatum Linn. (Verbenaceae) is an important and widely used medicinal plant, reported to contain active bitter substance like clerodin, has been widely used as tonic and anthelmintic agent in the country sides of North India. Though, variously used in Ayurveda, Unani system of medicine and Homeopathy in case of ailments like diarrhoea, skin disorders, venereal and scrofulous complaints, wounds, post-natal complications, as vermifuge, laxative and cholagogue, for the removal of ascarids in anus, as external applications on tumours, etc.,
Background: The present study reports the antiulcer properties of 50% ethanolic extract of Clerodendron infortunatum Linn. (Verbenaceae) leaves have assessed in different acute and chronic gastric ulcer models in rats.
Methods: EECI (100, 200 and 400 mg/kg body weight) was administered orally, twice daily for 5 days for prevention from ethanol (EtOH), Cold-restraint stress (CRS), Pylorus-ligation (PL) and 10 days for prevention of acetic acid induced ulcers.
Results: The EECI showed significant gastric ulcer protective effect in doses of 400 mg/kg, when given twice daily for 5 days against gastric ulcers induced by ethanol (EtOH), cold restraint stress (CRS) and pyloric ligation (PL). EECI showed dose dependent decrease in ulcer index (UI) against ulcers induced by: (i) Ethanol (control UI: 29.52±2.4 mm2/rat, EECI decrease 21.12±2.3 – 5.3±1.0 (ii) Cold restraint stress (CRS) (control UI: 32.13±2.1, EECI decrease 24.02±2.2 – 4.7±1.1 (iii) pylorus ligation (control UI: 29.25±2.4 mm2/rat, EECI decrease 22.32±2.7 – 5.3±1.0, EECI 400 mg/kg significantly healed ulcers induced by 50% acetic acid after 5 (control UI: 32.30 ± 2.9, EECI decrease 26.27±1.9 – 8.56±0.98 and after 10 days treatment (control UI: 29.02 ± 2.6, healing 21.28±2.1 – 5.78±1.2. EECI prevents the oxidative damage of gastric mucosa by blocking lipid peroxidation and by significant decrease in superoxide dismutase, and increase in catalase activity.
Conclusions: Our results show that Clerodendron infortunatum Linn. (Verbenaceae) possess significant gastro-protective activity which might be due to gastric defence factors and clerodin might be the main constituents responsible for this activity.
ANTIDIABETIC AND ANTIDYSLIPIDEMIC PROPERTIES OF GOA-111, A MIXTURE OF GYMNEMA SYLVESTRAE, OCIMUM SANCTUM AND AZADIRACHTA INDICA EXTRACT IN THE RATIO OF 1:1:1 STUDIED IN HIGH FAT DIET FED- LOW DOSE STREPTOZOTOCIN INDUCED EXPERIMENTAL TYPE 2 DIABETES IN RAT
Authors: Sathyanarayan Sangeetha , Pillai K. Sadasivan 
Published: September 2019

Diabetes mellitus emerges from multiple biochemical and cellular impairments, including decreased insulin secretion from the pancreatic β-cells and impaired insulin action in peripheral tissues. The present study was systematically carried out to evaluate antidiabetic and antidyslipidemic properties of GOA-111,a herbal extract containing a mixture of Gymnema sylvestrae, Ocimum sanctum leaves and seed kernel of Azadirachta indica in the ratio of 1:1:1 in ameliorating both the primary and secondary complications of type 2 diabetes mellitus in high fat diet fed low dose streptozotocin induced diabetic rats
Experimental type 2 diabetes was induced with a low dose streptozotocin in rats fed on a high fat diet. Diabetic rats were treated with three different doses GOA 111 (150,300 and 450 mg/Kg b.wt/rat/day) for 30 days. The toxicological parameters such as AST, ALT and ALP were assayed. Biochemical parameters such as fasting blood glucose, glycosylated hemoglobin, insulin, insulin resistance and lipid profile were measured.
Oral treatment with GOA 111 significantly decreased the elevated levels of fasting glucose, glycosylated hemoglobin, AST, ALT and ALP. The insulin level was improved in insulin resistant diabetic rats. GOA 111 also normalized the lipid profile.
Though the results showed a dose dependent impact on the parameters, a dose of 300mg/Kg B/W/rat/day GOA 111 exerts maximum potential anti-hyperglycemic and antidyslipidemic effects in HFD/STZ-induced type 2 diabetic rats.
Key words: GOA 111; High fat diet; Streptozotocin; antidiabetic; antidyslipidemic
A BENIGN SYNTHESIS OF 2-AMINO-3-CYANO-4H-BENZOPYRANS VIA DOMINO REACTION
Authors: SILAMBARASAN SEKAR SILAMBU , Abdul Nasser A. Jamal 
Published: September 2019

A green and operationally simple approach domino reaction has been developed for the synthesis of 2-amino-3-cyano- 4H-chromene derivatives from aromatic aldehydes, resorcinol and malononitrile in aqueous medium. This work represents the first example of catalyst free and organic solvents free multi-component reactions for the synthesis of pharmaceutically important chromene derivatives. The structures of the synthesized compounds were confirmed by 1H NMR, 13C NMR, IR, Mass and single crystal XRD.
Keywords: Benzopyrans, malononitrile, Michael addition reaction, domino reaction, water mediated synthesis.
Evaluation of anti-anxiety activity of Mucuna pruriens
Authors: Singh Shobhit , Gupta Pushpraj , Gupta Rishikesh 
Published: September 2019

Mucuna pruriens, also known as Velvet Bean, Mucuna pruriens has been used for centuries by Ayurvedic herbalists for overall wellness. Mucuna pruriens provides support for brain function, muscle health and libido. Mucuna pruriens has also been shown to have diuretic effects. It increases tissue resiliency and improves coordination. Mucuna can also increase testosterone levels, which in turn can lead to increased muscle mass and strength. It also supports the nervous and reproductive systems in the body. anti-oxidant activity of M. pruriens has been also demonstrated in vitro by its ability to scavenge DPPH radicals and reactive oxygen species. This is an excellent natural source of L-dopa and 5-hydroxy tryptophan (5-HT) Present study was designed to evaluate the anti-anxiety activity of Mucuna pruriens extract in Swiss albino mice. Three doses of Mucuna pruriens (100, 200,400 mg/kg, p.o.) and standard dose of Buspirone (5 mg/kg, i.p.) were used for evaluation of the anti-anxiety activity. The elevated plus maze (EPM) was used to take as a measure of antianxiety effect. Mucuna pruriens at the doses of 200 mg/kg and 400 mg/kg significantly reduced the time spent and no. of entries in closed arm, increased the time spent and entries into open arm in elevated plus maze (p<0.05) as compared to control group. These results indicate that MP may be possesses antianxiety property.
Keywords: Anxiety, Elevated plus maze, Mucuna pruriens, Buspirone, Swiss Albino Mice.
FORMULATION AND EVALUATION OF COLON TARGETED DRUG DELIVERY SYSTEM OF BUSULFAN: USING COMBINATION OF pH AND TIME DEPENDANT SYSTEMS
Authors: JAHNAVI SAI , Sharma GS , Rama B , Jyothirani , 
Published: September 2019

In present work Colon targeting drug delivery system was developed for Busulfan an anticancer drug by using combination of delayed systems one is pH dependant and other is time dependant delayed system. Rapid release core tablet (RRCT) formulations were prepared using Busulfan drug with different disintegrating agents in different concentrations. The pre-compression and post-compression parameters of all formulations were determined and the values were found to be satisfactory. From the In-vitro dissolution studies, F6 formulation with 12% Hydroxy propyl cellulose (HPC) was the best formulation. For optimized RRCT formulation press coat was done by using Xanthum Gum and Ethyl Cellulose (EC) in different ratios. Press coated tablet delays the drug release up to 8 hours based on the nature and concentrations of the polymer. Each press coated tablet was coated using enteric solution made of HPMC phthalate, Myvacet and color dissolved in ethanol. Enteric press coated tablets (EPCT) were delayed drug release up to 2hrs in fed condition due to pH dependant delayed system. Based on dissolution studies of EPCT formulations, C3OPF formulation was optimized and showed delayed release pattern in a much customized manner. As a result of this study it may be concluded that the colon targeted drug delivery tablets using a combination of two polymers in optimized concentrations can be used to increase the delayed action of drug release to deliver the drug in a delayed manner.
Key words: Colon, RRCT, HPC, Xanthum gum and EPCT
Formulation and Evaluation of Polyherbal Shampoo to Promote Hair Growth and Provide Antidandruff Action
Authors: Lodha Gaurav 
Published: September 2019

The assurance of therapy with minimal side effects has been proven that ayurvedic formulation is to be promising for cosmetic use too. Maintenance of other factor shall not fulfill the need so extraneous treatment is essential that to which is safe. In case of hair disorder like dandruff problem, proper selection of ayurvedic ingredient with their required amounts, dosage form can be formulated as powder shampoo to fight against dandruff. A more radical approach in reducing the synthetic ingredient is by incorporating natural extract whose functionality is comparable with their synthetic ingredient. A shampoo is a cleansing aid for the hair and is counted among the foremost beuty products. Several herbs are reported to be effecting is controlling such fungi in our laboratory an antidandruff herbal shampoo –Herbello was prepared and characterized. Certain improvements, especially with respect to viscosity, conditioning ability and antidandruff activity were needed. Most effective herbs were chosen and used in different combination for preparation of shampoo in order to improve antidandruff activity. This herbal shampoo was formulated using natural ingredient like Bhringraj (Eclipta Alba), Fenugreek(methi), Azadirachta indica (neem), Acacia concinna (shikakai), Sapindus mukorossi(reetha), Ocimum santum (tulsi), Piper betle (paan), Hhibiscus rosa sinensis (Gurhal), Camellia sinesis (green tea leaf), Citrus aurantifolia (lemon), Phyllanthus emblica (amla), Eclipta alba (Brhingaraj leaf powder), Aloe Vera (Aloe leaf Powder), Ashwagandha powder, Triphala powder Nagarmotha Powder, Brahmi Root. The formulation at laboratory scale was done and evaluated for number of parameters to ensure its safety, stability and efficacy.
Keywords: Hair Dandruff shampoo, cream shampoo, Herbal Material, Antidandruff shampoo.
Therapeutic Potential of Evolvulus alsinoides
Authors: Siraj Mantasha Binth , Khan Asim Ali , Jahangir Umar 
Published: September 2019

Background: Evolvulusalsinoidesis a well-known herbal drug possessing various promising medicinal properties described by prominent ancient scholars and also numerous preclinical and clinical researches has been performed, thus attestingit’s ample of pharmacological actions. So, thorough review of classical as well as contemporary literature has been executed on Evolvulusalsinoides to validate the pharmacological actions mentioned. .
Methods:For classical review,a comprehensive search of Unani literature is done and for latest research work on evolvulus, articles published in English language using PubMed, MEDLINE, and the Google scholar with search term including Sahnkpushpi, sankhaoli, Evolvulusalsinoides since 1991 to 2019 is done.
Results: The search includescontemporary literature, ethnomedicinal sources and 35 research articles from 1992 to 2019 which further ascertains various pharmacological actions being mentioned in Unani literature including anti-inflammatory, anti-diarrheal, anti-helminthic, anti-convulsantand nootropicproperty of herb.
Conclusion:
The pharmacological action and therapeutic application of Shankhaholi/ Shankpushpiwhich ismentioned inclassical Unani literature are in accordance with latest research. Despite of having several researches on Evolvulusalsinoides there are still numerous indications mentioned in classical literature which are yet to be explored.

Keywords: Evolvulusalsinoides, herb, Unani, contemporary.
Nephroprotection in Unani Medicine through Herbal Medicine & their research scope: A Review
Authors: Khatoon Rizwana , Aslam Dr. Mohammad , Chaudhary Shahid Shah 
Published: September 2019

Plants are very potential & vital source for human health and also used therapeutically in the various kidney disorders due to presence of phytochemical constituents. There are numerous herbs existing that have more pharmacological activities including with nephroprotective activity. Now a days herbal drugs are verified & proved as nephroprotective agents and used for improving renal health, even reverse renal damages. The current review is targeted to explain the Unani & modern concept of kidney disorders, nephrotoxicity and the list of scientifically proved medicinal plants having nephroprotective activity medicinal plants which used in the treatment of renal disorders.
Keywords: Nephroprotection, Unani Medicine, Kidney disorders
Antioxidant Activity and total Phenolic Content of Defatted Scenedesmus quadricauda KDPSC2 Biomass Extract by Microbial Fermentation
Authors: Sarumathi V. , Dhandayuthapani Krishnan , Mazher Sultana 
Published: September 2019

Microalgae biomass are considered as sustainable sources for various bioactive compounds. The objective of this study to evaluate the defatted biomass of green microalga Scenedesmus quadricauda KDPSC2 as a source for enhancement of total phenolic content (TPC) and antioxidant activity by microbial fermentation. Ultrasonic assisted hydrolysate was prepared from defatted biomass using ultrasound power density of 0.3 Wcm-2 at 10 min. Then the prepared defatted biomass hydrolysate (DBH) was used as soul medium for fermentation by five different microbial strains such as Bacillus amyloliquefaciens, B. stearothermophilus, B. subtilis, Saccharomyces cerevisiae NITTS1 and Cyberlindnera jadinii MMS7. Among these microbial strains, C. jadinii MMS7 was selected for further study because it was enhanced the TPC and antioxidant activity of DBH by fermentation. Besides, the fermentation conditions were optimized by classical method of optimization and found the pH 5.5, temperature 35 oC, agitation speed 150 rpm and 36 h as optimum physical parameters for enhancing the TPC and antioxidant activity of DBH by fermentation using C .jadinii MMS7. At these optimum conditions, 4.67 fold DPPH radical scavenging activity was obtained from DBH after fermentation. Therefore, this study demonstrates that the defatted biomass of S. quadricauda KDPSC2 could be a useful source for production of TPC by C. jadinii MMS7 fermentation.
Keywords: Cyberlindnera jadinii, Defatted biomass, Fermentation, Hydrolysate, Scenedesmus quadricauda, Total phenolic content.
Quantitative Estimation and Validation of Chlorthlidone and Azilsartan Medoximil in Bulk and Tablet Dosage Form by using RP-HPLC
Authors: Dighe Nachiket S. , Thorat Somnath K. , Shinde Ganesh S , Dhamak Kavita V 
Published: September 2019

The first reversed phase high performance liquid chromatographic method for Stability Indicating of, Azilsartan and chlorthalidone has been developed and validated to be a simple, sensitive, rapid, specific, precise, and accurate method. Chromatographic separation was achieved on Zorbax XBD-C8, 250mm × 4.6mm,5µm.Buffer pH5.5 : Methanol (60:40) as a mobile phase at flow rate of 1 ml/min. UV detection was operated at 234 nm and injection volum was 25 μl.. The proposed method showed good linearity, accuracy, precision and was successfully applied for determination of the drugs in laboratory prepared pharmaceutical dosage forms.
Keywords: Azilsartan and chlorthalidone, RP-HPLC, Stability Indicating.
Preformulation Studies of Pralidoxime Chloride for Formulation Development of Microspheres
Authors: Sharma Shyam Bihari , Jain Suman , Ganesan K. 
Published: September 2019

Microspheres are one of the novel drug delivery system which possess several applications and are made up of assorted polymers. Microspheres can be defined as solid, approximately spherical particles ranging in size from 1 to 1000 μm range in diameter having a core of drug and entirely outer layers of polymers as coating material. They are made up of polymeric, waxy or other protective materials i.e. biodegradable synthetic polymer and modified natural products such as starches, gums, proteins, fats and waxes. Preformulation is a group of studies that focus on the physicochemical properties of a new drug candidate that could affect the drug performance and the development of a dosage form. This couldprovide important information for formulation design or support the need for molecular modification. Every drug has intrinsic chemical and physical properties which has been consider before development of pharmaceutical formulation. This property provides the framework for drugs combination with pharmaceutical ingredients in the fabrication of dosage form. Objective of preformulation study is to develop the elegant, stable, effective and safe dosage form by establishing kinetic rate profile, compatibility with the other ingredients and establish Physico-chemical parameter of new drug substances. The purpose of the present study was to systematically investigate some of the important physicochemical properties of pralidoxime chloride for preparation of microspheres. The physicochemical properties such as solubility, pKa, dissolution, melting point, assay development, excipient compatibility etc. of pralidoxime chloride was carried out. Before selection of excipients, the Preformulation study of drug pralidoxime is completed for successful formulation of microspheres. The result of Preformulation studies shows good flow properties, excipient compatibility, solubility efficiency and melting point. From this study we concluded that pralidoximewith HPMC and EC can be used to formulate pralidoxime microspheres for modified release.
Keywords: Microspheres, Preformulation, Pralidoxime chloride, Physico-chemical parameter.