bluuebunny/crossref_metadata_2025_split huggingface dataset:
SWOT Analysis on JKN Implementation in Ngaliyan Health Center Semarang in 2016
Authors: Melani Florentina , Santjaka Aris , Latif Rr Vita Nur 
Published: February 2018

ABSTRACT
The position of Health Center (Puskesmas) as a first level health facility becomes the spearhead in good implementation of JKN (Jaminan Kesehatan Nasional or National Health Insurance). By using SWOT Analysis in 6M dimension (Men, Money, Method, Material, Machine, Market), it is expected to be an alternative for Ngaliyan Health Center to improve the work performance and become a reliable health facility for Ngaliyan citizens. And it can support the realization of totally covered insurance in 2019. This study aims to explore the strengths, weaknesses, opportunities, and threats to the Ngaliyan Health Center in organizing JKN service in 6M dimension (Men, Money, Method, Material, Market, Machine), to find the critical point and make KSF (Key Success Factor). The research is qualitative descriptive with structured in-depth interview approach. Using 15 informants selected by purposive sampling. The results of this study obtained a critical point that is on the dimension of money. There was a deficit between capitation and expenditure funds of the Health Center in the implementation of JKN.

ABSTRAK
Kedudukan puskesmas sebagai fasilitas kesehatan tingkat pertama menjadi ujung tombak pelaksanaan JKN yang baik. Dengan menggunakan Analisa SWOT dalam dimensi 6M (Men, Money, Method, Material, Machine, Market) diharapkan menjadi alternatif bagi puskesmas ngaliyan untuk meningkatkan prestasi kerja dan menjadi fasilitas kesehatan yang diandalkan bagi warga Ngaliyan. Serta bisa mendukung terwujudnya totally covered di tahun 2019. Penelitian ini bertujuan untuk mengeksplorasi Kekuatan, Kelemahan, Peluang, dan Ancaman bagi puskesmas Ngaliyan dalam menyelenggarakan pelayanan JKN dalam dimensi 6M (Men, Money, Method, Material, Market, Machine), untuk menemukan titik kritis, serta membuat FKK (Faktor Kunci Keberhasilan). Penelitian berupa kualitatif deskriptif dengan pendekatan wawancara mendalam terstruktur. Menggunakan 15 orang informan yang dipilih secara purposive sampling.Hasil penelitian ini didapatkan titik kritis yaitu pada dimensi money. Terdapat defisit antara dana kapitasi dan biaya yang dikeluarkan puskesmas dalam pelaksanaan JKN.
Preoperative medical treatment in Cushing’s syndrome: frequency of use and its impact on postoperative assessment: data from ERCUSYN
Authors: Valassi Elena , Franz Holger , Brue Thierry , Feelders Richard A , Netea-Maier Romana , Tsagarakis Stylianos , Webb Susan M , Yaneva Maria , Reincke Martin , Droste Michael , Komerdus Irina , Maiter Dominique , Kastelan Darko , Chanson Philippe , Pfeifer Marija , Strasburger Christian J , Tóth Miklós , Chabre Olivier , Krsek Michal , Fajardo Carmen , Bolanowski Marek , Santos Alicia , Trainer Peter J , Wass John A H , Tabarin Antoine , _ _ , _ _ , Ambrogio A , Aranda G , Arosio M , Balomenaki M , Beck-Peccoz P , Berr-Kirmair C , Bollerslev J , Carvalho D , Cavagnini F , Christ E , Demtröder F , Denes J , Dimopoulou C , Dreval A , Dusek T , Erdinc E , Evang J A , Fazel J , Fica S , Ghigo E , Goth M , Greenman Y , Greisa V , Halperin I , Hanzu FA , Hermus A , Johannsson G , Kamenicky P , Kasperlik-Zaluska A , Kirchner J , Kraljevic I , Kruszynska A , Lambrescu I , Lang S , Luger A , Marpole N , Martin S , Martinie M , Moros O , Newell-Price J , Orbetzova M , Paiva I , Pecori Giraldi F , Pereira A M , Pickel J , Pirags V , Ragnarsson O , Reghina A D , Riesgo P , Roberts M , Roerink S , Roig O , Rowan C , Rudenko P , A Sahnoun M , Salvador J , Sigurjonsdottir HA , Skoric Polovina T , Smith R , Stachowska B , Stalla G , Tőke J , Ubina E , Vinay S , Wagenmakers M , Werner S , Young J , Zdunowski P , Zopf K , Zopp S , Zosin I 
Published: February 2018

Background
Surgery is the definitive treatment of Cushing’s syndrome (CS) but medications may also be used as a first-line therapy. Whether preoperative medical treatment (PMT) affects postoperative outcome remains controversial.

Objective
(1) Evaluate how frequently PMT is given to CS patients across Europe; (2) examine differences in preoperative characteristics of patients who receive PMT and those who undergo primary surgery and (3) determine if PMT influences postoperative outcome in pituitary-dependent CS (PIT-CS).

Patients and methods
1143 CS patients entered into the ERCUSYN database from 57 centers in 26 countries. Sixty-nine percent had PIT-CS, 25% adrenal-dependent CS (ADR-CS), 5% CS from an ectopic source (ECT-CS) and 1% were classified as having CS from other causes (OTH-CS).

Results
Twenty per cent of patients took PMT. ECT-CS and PIT-CS were more likely to receive PMT compared to ADR-CS (P < 0.001). Most commonly used drugs were ketoconazole (62%), metyrapone (16%) and a combination of both (12%). Median (interquartile range) duration of PMT was 109 (98) days. PIT-CS patients treated with PMT had more severe clinical features at diagnosis and poorer quality of life compared to those undergoing primary surgery (SX) (P < 0.05). Within 7 days of surgery, PIT-CS patients treated with PMT were more likely to have normal cortisol (P < 0.01) and a lower remission rate (P < 0.01). Within 6 months of surgery, no differences in morbidity or remission rates were observed between SX and PMT groups.

Conclusions
PMT may confound the interpretation of immediate postoperative outcome. Follow-up is recommended to definitely evaluate surgical results.
Nutrient Intake in the First Two Weeks of Life and Brain Growth in Preterm Neonates
Authors: Schneider Juliane , Fischer Fumeaux Céline J. , Duerden Emma G. , Guo Ting , Foong Justin , Graz Myriam Bickle , Hagmann Patric , Chakravarty M. Mallar , Hüppi Petra S. , Beauport Lydie , Truttmann Anita C. , Miller Steven P. 
Published: February 2018

BACKGROUND:
Optimizing early nutritional intake in preterm neonates may promote brain health and neurodevelopment through enhanced brain maturation. Our objectives were (1) to determine the association of energy and macronutrient intake in the first 2 weeks of life with regional and total brain growth and white matter (WM) maturation, assessed by 3 serial MRI scans in preterm neonates; (2) to examine how critical illness modifies this association; and (3) to investigate the relationship with neurodevelopmental outcomes.

METHODS:
Forty-nine preterm neonates (21 boys, median [interquartile range] gestational age: 27.6 [2.3] weeks) were scanned serially at the following median postmenstrual weeks: 29.4, 31.7, and 41. The total brain, basal nuclei, and cerebellum were semiautomatically segmented. Fractional anisotropy was extracted from diffusion tensor imaging data. Nutritional intake from day of life 1 to 14 was monitored and clinical factors were collected.

RESULTS:
Greater energy and lipid intake predicted increased total brain and basal nuclei volumes over the course of neonatal care to term-equivalent age. Similarly, energy and lipid intake were significantly associated with fractional anisotropy values in selected WM tracts. The association of ventilation duration with smaller brain volumes was attenuated by higher energy intake. Brain growth predicted psychomotor outcome at 18 months’ corrected age.

CONCLUSIONS:
In preterm neonates, greater energy and enteral feeding during the first 2 weeks of life predicted more robust brain growth and accelerated WM maturation. The long-lasting effect of early nutrition on neurodevelopment may be mediated by enhanced brain growth. Optimizing nutrition in preterm neonates may represent a potential avenue to mitigate the adverse brain health consequences of critical illness.
A mikro-RNS-ek szerepe az agyalapimirigy-daganatok tumorbiológiájában
Authors: Németh Kinga , Darvasi Ottó , Szücs Nikolette , Czirják Sándor , Butz Henriett 
Published: February 2018

Abstract: MicroRNAs (miRNAs) are short, single stranded RNA molecules which play regulatory roles through posttranscriptional regulation of their target genes. Based on our current knowledge, more than 30% of the human protein-coding genes are regulated by miRNAs, hence influencing basic cellular mechanisms including cell proliferation, differentiation and cell death. Differential miRNA expression pattern has been detected in many different types of tumors and, recently, several publications have referred to miRNAs as potential therapeutic targets. Through adjustment of miRNA levels by artificial miRNAs administration or miRNA inhibition, we can influence not only one target gene but also complex biological pathways. Pituitary adenoma is the second most frequent intracranial tumor. In spite of this, the molecular mechanism of the pituitary adenoma formation is not yet entirely revealed. Recently, more and more evidences have been found suggesting that miRNAs have an important role in pituitary adenoma pathogenesis. Here, we summarize the recent results related to this role and highlight the therapeutic potentials in pituitary adenomas. Orv Hetil. 2018; 159(7): 252–259.
Háziorvosok és idősellátás egy kérdőíves kutatás tükrében
Authors: Tróbert Anett Mária , Széman Zsuzsanna 
Published: February 2018

Abstract: According to statistical data, the number of healthy life years is not increasing in proportion with the longer average life expectancy. In the ageing societies, the long-term care systems are increasingly overburdened; cost-efficient operation and the related coordination of services is one of the key questions for their sustainability. The present separation of the health care and social care systems causes numerous difficulties. One aim of the online research by questionnaire was to survey the attitude of general practitioners – who play a very important part in care for the elderly – towards their elder patients, the patients’ family members, and social workers providing eldercare. The other aim was to gather information on shortcomings experienced by doctors in the care system and on what possibilities general practitioners see for the improvement of eldercare. Semi-structured questionnaires were applied and analysed by descriptive and content methodology. The questionnaires were sent out to 5060 addresses around the country: a total of 145 were returned filled in. The respondents made many recommendations for the improvement of eldercare in the categories of development of social services, family support, development of health services, and societal cooperation. The areas in need of development named by the general practitioners are closely interrelated: the reform of social care would support the health care system and vice versa. More effective operation of the health and social care systems would ease the burdens of families, and at the same time encourage more active participation of families in the care process. And the systematic education of society and communities is a long-term investment that would strengthen a positive attitude towards old age and a value-oriented view of the ageing process that is one of the basic conditions for successful social integration of the elderly. Orv Hetil. 2018; 159(8): 312–319.
Szteroid-21-hidroxiláz-deficientia, a congenitalis adrenalis hyperplasia leggyakoribb oka
Authors: Doleschall Márton , Török Dóra , Mészáros Katalin , Luczay Andrea , Halász Zita , Németh Krisztina , Szücs Nikolette , Kiss Róbert , Tőke Judit , Sólyom János , Fekete György , Patócs Attila , Igaz Péter , Tóth Miklós 
Published: February 2018

Abstract: Congenital adrenal hyperplasia is a group of genetic diseases due to the disablement of 7 genes; one of them is steroid 21-hydroxylase deficiency. The genes of congenital adrenal hyperplasia encode enzymes taking part in the steroidogenesis of adrenal gland. Steroid 21-hydroxylase deficiency is an autosomal recessive disorder caused by mutations of the steroid 21-hydroxylase gene. The mutations of steroid 21-hydroxylase gene cause 95% of the congenital adrenal hyperplasia cases. Although the non-classic steroid 21-hydroxylase deficiency with mild symptoms is seldom diagnosed, the classic steroid 21-hydroxylase deficiency may lead to life-threatening salt-wasting and adrenal crises due to the insufficient aldosterone and cortisol serum levels. The classic type requires life-long steroid replacement which may result in cushingoid side effects, and typical comorbidities may be also developed. The patients’ quality of life is decreased, and their mortality is much higher than that of the population without steroid 21-hydroxylase deficiency. The diagnosis, consequences and the patients’ life-long clinical care require a multidisciplinary approach: the specialists in pediatrics, internal medicine, endocrinology, laboratory medicine, genetic diagnostics, surgery, obstetrics-gynecology and psychology need to work together. Orv Hetil. 2018; 159(7): 269–277.
EKG-gyöngyszem: Pseudoinfarctusos Q-hullámok és alacsony kilengések
Authors: Tomcsányi János 
Published: February 2018

Abstract: Therapy refracter heart failure is presented. The admission ECG shows low voltage and pseudoinfarct Q waves highly diagnostic for the etiology of heart failure. Orv Hetil. 2018; 159(8): 327–329.
Utilization of immunochemical methods to detect Phytophthora fraga-riae – a quarantine pathogen of strawberry
Authors: Pekárová B. , Krátká J. , Slováček J. 
Published: February 2018

Polyclonal antibodies anti-PfP IgG and anti-PfM IgG and monoclonal antibody MAb29 were prepared to detect a quarantine pathogen of strawberry, Phytophthora fragariae. Laboratory rabbits and mice were immunized using purified and unpurified protein extracts from the mycelial mass of the pathogen. All prepared antibodies were genus-specific, therefore Phytophthora cactorum was also detected. Except for Pythium ultimum, the antibodies did not cross-react with other pathogenic fungi, such as Botrytis cinerea, Colletotrichum acutatum, Fusarium sp., Verticillium albo-atrum. PTA-ELISA was used to test the antibodies. P. fragariae was detected in artificially infected strawberries (cultivars Elsanta, Kama and Vanda) by means of PTA-ELISA, immunoprinting and dot blot. Detection of the pathogen was optimal in undamaged roots or roots with necrotic tips only. At a later stage of infection, when whole roots were necrotic, the crown was more suitable for successful detection. To detect P. fragariae at the early stages of infection it is recommended to use at least two of the three mentioned immunotechniques.
A new concept of economic injury level that includes penalization of damage to quality and safety of agricultural products
Authors: Stejskal V. 
Published: February 2018

The traditional model of Economic Injury Level (EIL) does not allow to directly incorporate aspects of damage to quality and safety of a product (Dq) into the decision-making process to control a pest (pathogen, weed, arthropod, vertebrate). This work now attempts to generalize a concept of EIL by (i) separating damages to quality and safety (i.e. Dq and EILq) from quantitative (i.e. Dw and EILw) types of damage (D) in the traditional EIL-equation, and (ii) by establishing a new way of estimation of EILq based on the penalization of quality and/or safety damage. The importance to distinguish between the terms EIL, EILw and EILq is discussed, and a calculation of the new index (Z), enabling the comparison of the relative economic importance of qualitative and quantitative damage caused by a particular level of pest infestation or disease severity, is proposed.
Virulence of wheat leaf rust in Slovakia in 1997–1998
Authors: Bartoš P. , Huszár J. , Herzová E. 
Published: February 2018

In 1997–1998 virulence of the leaf rust population was studied on near isogenic Thatcher lines with the genes for resistance Lr1, Lr2a, Lr2b, Lr2c, Lr3, Lr9, Lrll, Lr15, Lr/7, Lr19, Lr21, Lr23, Lr24, Lr26 and Lr28, and on the standard differentials Mala­ koff, Carina, Brevit, Webster, Loros, Mediterranean, Hussar, Democrat and the supplemental cultivar Salzmtinder Bartweizen. All 55 analyzed rust samples were avirulent on Lr9, Lr19, Lr24 and Lr28.On the standard differentials, races 61SaBa, 77SaBa, 77/57SaBa, 2SaBa, 77, 12SaBa, 62SaBa, 6, 6SaBa and 14 were determined. Races 61SaBa and 77SaBa (77/57SaBa) prevailed in both years. Races 6 and 6SaBa were found for the first time. The effectiveness of leaf rust resistance genes in registered cultivars under field conditions in variety trials is discussed.
STRONG, S.I.; FACH GÓMEZ, K.; CARBALLO PIÑEIRO, L., Comparative Law for Spanish-English Speaking Lawyers. Legal Cultures, Legal Terms and Legal Practices / Derecho comparado para abogados anglo- e hispanoparlantes. Culturas jurídicas, términos jurídicos y prácticas jurídicas, Edward Elgar Publishing, Cheltenham/Northampton, 2016, 672 págs.
Authors: Oanta Gabriela 
Published: February 2018

Recensión de la obra STRONG, S.I.; FACH GÓMEZ, K.; CARBALLO PIÑEIRO, L., Comparative Law for Spanish-English Speaking Lawyers. Legal Cultures, Legal Terms and Legal Practices / Derecho comparado para abogados anglo- e hispanoparlantes. Culturas jurídicas, términos jurídicos y prácticas jurídicas, Edward Elgar Publishing, Cheltenham/Northampton, 2016, 672 págs.La obra objeto de esta recensión es fruto de la original labor realizada por tres profesoras de Derecho (S.I. Strong, Katia Fach Gómez, y Laura Carballo Piñeiro) procedentes de tres Universidades diferentes de Estados Unidos de América y de España (Universidad de Missouri, Universidad de Zaragoza, y Universidad de Santiago de Compostela). Las autoras de este libro se han propuesto concretar un ambicioso proyecto humano y profesional, esto es escribir una obra totalmente bilingüe – en los dos primeros idiomas de mayor difusión internacional (inglés y español) – dedicada, desde una perspectiva del Derecho comparado, a las culturas jurídicas, empresariales y sociales, sin perder de vista en ningún momento que su trabajo será manejado sobre todo por personas con formación jurídica con un buen dominio del inglés (para los hispanófonos) o del español (para los anglófonos).
O mecanismo de resolución de controversias no ACTI
Authors: Soto Díaz David 
Published: February 2018

A arbitraxe entre Estados e investidores particulares doutros Estados, coñecida polas súas siglas en inglés, ISDS, ten sido obxecto de críticas ao longo dos últimos anos, polas malas consecuencias que ten tido especialmente nos países en vías de desenvolvemento. O Acordo Transatlántico para o Comercio e o Investimento, máis coñecido polas súas siglas en inglés TTIP, prevía incorporar, nun primeiro momento este mecanismo de arbitraxe. Máis tarde debido á oposición popular ao Tratado, a Comisión Europea puxo sobre a mesa a posibilidade de establecer un Tribunal Permanente. O obxectivo deste traballo é analizar o mecanismo de acción da arbitraxe ISDS e do novo Tribunal proposto pola Comisión Europea.
KAIDAH HAFALAN AL-QURAN PADA MADRASAH TAHFIZ ANNUR MARKAZ YALA DAN MADRASAH DARUSSALAM RANGEK NARATTIWAT DI THAILAD SELATAN
Authors: Mahama Ahmadzakee , Jehwae Phaosan 
Published: February 2018

This paper purpose to examine the rules of recitation of the al-Qur’an in Southern Thailand at Madrasah Annur Markaz Yala and Madrasah Darussalam. The author tries to see which rules are more practical to be practiced in the process of memorizing the al-Qur’an between the two rules. This study looks at current developments either at the stage of the academic Madrasah or in the religious section of each student in each method of guiding to memorize the al-Qur’an with the same time period of purpose as to memorize what is memorized. In this study is to see the good rules to use in order to give birth to the memorizers of the al- Qur'an are really good in terms of memorization. It will also be discussed about the law of memorizing the al-Qur’an, the advantages memorization of the al-Qur’an and the important of memorizing the al-Qur’an which in this study the authors will analyze and determine the student in one madrasah as many as 60 people with a share of 10 juz, 20 juz and 30 juz .
Avrupa Ortak Kültür ve Sanat Mirasının Korunmasında Avrupa Birliği'nin Çalışmaları: Avrupa Kültür Başkenti Programı Özelinde Bir İnceleme
Authors: Akdemir Erhan 
Published: February 2018

Kültür ve sanat sahası kentler için yeni bir endüstri biçimine, kültürel endüstriye dönüşmüş du-
rumdadır. Ancak bu endüstri sadece ekonomik kazanç sağlamayı değil ortak kültürel ve sanatsal
mirasın ortaya çıkarılmasında da önemli bir araç olarak kabul edilmektedir. Buradan hareketle,
Avrupa Kültür Başkenti programı da bu hususları içerecek şekilde hem Avrupa kentlerinin sosyoekonomik kalkınmalarına katkı sağlayabilecek hem de Avrupa’nın ortak kültürel ve sanatsal
mirası konusunda bir aidiyet ve bilinç yaratabilecek bir program, proje ve katalizör durumundadır. Bu makale çalışması ayrıca AB bütünleşme süreci içerisinde de ortak Avrupa kültür ve sanat
mirasının varlığının korunmasının önemli bir role sahip olduğunu savunmaktadır.&nbsp;
Estado de la cuestión de la selección de características y sus aplicaciones
Authors: Orenes Casanova Yolanda 
Published: February 2018

En este artículo se tienen principalmente dos objetivos: primero, el estudio de forma exhaustiva del método de Selección de Características, y segundo, la clasificación de diferentes aplicaciones de uso de dicho método, todo ello servirá para elaborar un Estado del Arte del tema. Que sirve de punto de partida para establecer diferentes problemas abiertos que quedan pendientes de estudiar en el futuro. Asimismo, cabe destacar que se ha realizado una recopilación bastante diversa en cuanto a las aplicaciones encontradas de la Selección de Características obtenidas de diferentes fuentes bibliográficas, lo que permite hacerse una idea sobre la relevancia de este tipo de técnicas en la actualidad, sobre todo en un mundo en el que cada vez hay más información y los agentes económicos y sociales quieren extraer conclusiones relevantes de la misma que les ayude a tomar mejores decisiones. Tras esta revisión de la literatura sobre la Selección de Características encontramos que existe una cierta problemática sobre la Clasificación que posibilita el establecimiento de una futura línea de investigación que mejore los resultados de investigaciones anteriores. El objetivo de esta futura línea de investigación debe enfocarse a la reducción de la complejidad computacional de las técnicas de Selección de Características, es decir, la dimensión de las entradas y mejora del rendimiento del clasificador. Adicionalmente se observa que queda pendiente de investigar nuevos métodos que permitan trabajar con variables numéricas y con ello que favorezcan una mayor aplicabilidad de las técnicas de Selección de Características.
Annual flow duration curve model for ungauged basins
Authors: Burgan Halil Ibrahim , Aksoy Hafzullah 
Published: February 2018

AbstractA flow duration curve (FDC) plots the percentage of time that flow in a stream is equal to or exceeding a given value. In a gauged basin, it is obtained by sorting the observed flow from the largest to the smallest, and plotting against the corresponding exceedance probability. At ungauged basins where no data exist, the need for developing empirical methods emerges. This study aims at developing an FDC model for ungauged basins. The model is based on the normalized nondimensional annual mean flow quantiles. The annual mean flow is empirically calculated by a regression equation that takes drainage area and annual precipitation as input. Slope of the channel is additionally considered in the regression, however no better performance is achieved. Seyhan and Ceyhan basins in the Mediterranean region in southern Turkey are chosen as the study area. Data from 109 gauging stations are used for the calibration and validation of the model. Gauging stations on the tributaries are studied with a view to limiting anthropogenic activities on the rivers. Results of the application are found so promising that the model can be considered a good foundation for the development of FDCs at ungauged basins.