bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cost-utility analysis on telemonitoring of users with pacemakers: The PONIENTE study
Authors: Lopez-Villegas Antonio , Catalan-Matamoros Daniel , Robles-Musso Emilio , Bautista-Mesa Rafael , Peiro Salvador 
Published: April 2018

Introduction Few studies have confirmed the cost-saving of telemonitoring of users with pacemakers (PMs). The purpose of this controlled, non-randomised, non-masked clinical trial was to perform an economic assessment of telemonitoring (TM) of users with PMs and check whether TM offers a cost-utility alternative to conventional follow-up in hospital. Methods Eighty-two patients implanted with an internet-based transmission PM were selected to receive either conventional follow-up in hospital ( n = 52) or TM ( n = 30) from their homes. The data were collected during 12 months while patients were being monitored. The economic assessment of the PONIENTE study was performed as per the perspectives of National Health Service (NHS) and patients. A cost-utility analysis was conducted to measure whether the TM of patients with PMs is cost-effective in terms of costs per gained quality-adjusted life years (QALYs). Results There was a significant cost-saving for participants in the TM group in comparison with the participants in the conventional follow-up group. From the NHS’s perspective, the patients in the TM group gained 0.09 QALYs more than the patients in the conventional follow-up group over 12 months, with a cost saving of 57.64% (€46.51 versus €109.79, respectively; p < 0.001) per participant per year. In-office visits were reduced by 52.49% in the TM group. The costs related to the patient perspective were lower in the TM group than in the conventional follow-up group (€31.82 versus €73.48, respectively; p < 0.005). The costs per QALY were 61.68% higher in the in-office monitoring group. Discussion The cost-utility analysis performed in the PONIENTE study showed that the TM of users with PMs appears to be a significant cost-effective alternative to conventional follow-up in hospital.
Examination of Spiritual Needs in Hurricane Sandy Disaster Recovery Through Clinical Pastoral Education Verbatims
Authors: Kestenbaum Allison , Fleischman Catherine Anne , Dabis Marta , Birnbaum Bette , Dunn Laura B. 
Published: April 2018

Objectives Spiritual support is an essential component to disaster response and recovery. The goals of this study were to (a) provide a qualitative examination of spiritual needs of recipients of disaster relief after Hurricane Sandy, as observed by spiritual care interns in “verbatims”; (b) demonstrate the feasibility of conducting research with providers of disaster spiritual care. Methods The study was accomplished through analysis (including codebook development and transcript coding) of written pastoral reports—aka “verbatims” ( n = 18)—as well as audio-recorded, transcribed seminars ( n = 23). Clinical Pastoral Education verbatims offer qualitative data in the form of confidential, anonymous reports of what the students do in the field. Results Analysis of coded transcripts yielded several themes and subthemes as results. Significance of Results Major themes include: (a) the feasibility of research for CPE students as subject; (b) the discussion of magnitude of the storm and aftermath, as a spiritual need in disaster; (c) the relationship between “normative crisis” and disaster; (d) the use of metaphors and images to describe disaster experiences.
Unaccounted Workload Factor: Game-Day Pitch Counts in High School Baseball Pitchers—An Observational Study
Authors: Zaremski Jason L. , Zeppieri Giorgio , Jones Deborah L. , Tripp Brady L. , Bruner Michelle , Vincent Heather K. , Horodyski MaryBeth 
Published: April 2018

Background: Throwing injuries are common in high school baseball. Known risk factors include excessive pitch counts, year-round pitching, and pitching with arm pain and fatigue. Despite the evidence, the prevalence of pitching injuries among high school players has not decreased. One possibility to explain this pattern is that players accumulate unaccounted pitch volume during warm-up and bullpen activity, but this has not yet been examined. Hypotheses: Our primary hypothesis was that approximately 30% to 40% of pitches thrown off a mound by high school pitchers during a game-day outing are unaccounted for in current data but will be revealed when bullpen sessions and warm-up pitches are included. Our secondary hypothesis was that there is wide variability among players in the number of bullpen pitches thrown per outing. Study Design: Cross-sectional study; Level of evidence, 3. Methods: Researchers counted all pitches thrown off a mound during varsity high school baseball games played by 34 high schools in North Central Florida during the 2017 season. Results: We recorded 13,769 total pitches during 115 varsity high school baseball starting pitcher outings. The mean ± SD pitch numbers per game were calculated for bullpen activity (27.2 ± 9.4), warm-up (23.6 ±8.0), live games (68.9 ±19.7), and total pitches per game (119.7 ± 27.8). Thus, 42.4% of the pitches performed were not accounted for in the pitch count monitoring of these players. The number of bullpen pitches thrown varied widely among players, with 25% of participants in our data set throwing fewer than 22 pitches and 25% throwing more than 33 pitches per outing. Conclusion: In high school baseball players, pitch count monitoring does not account for the substantial volume of pitching that occurs during warm-up and bullpen activity during the playing season. These extra pitches should be closely monitored to help mitigate the risk of overuse injury.
Seismic inversion and uncertainty quantification using transdimensional Markov chain Monte Carlo method
Authors: Zhu Dehan , Gibson Richard 
Published: April 2018

We applied a transdimensional stochastic inversion algorithm, reversible jump Markov chain Monte Carlo (rjMCMC), to angle-stack seismic inversion for characterization of reservoir acoustic and shear impedance with uncertainty quantification. The rjMCMC is able to infer the number of parameters for the model as well as the parameter values. In our case, the number of parameters depends on the number of model layers for a given data set. We also use this method in uncertainty quantification because a transdimensional sampling helps prevent underparameterization or strong overparameterization. An ensemble of models with proper parameterization can improve parameter estimation and uncertainty quantification. Our new results in uncertainty analysis indicate that (1) the uncertainty in seismic inversion, including uncertainty in earth properties and their locations, is related to the discontinuity of property across an interface, and (2) there is a trade-off between property uncertainty and location uncertainty. A stronger discontinuity will induce more property uncertainty but less location uncertainty at the discontinuity interface. Therefore, we further use the inversion uncertainty as a novel seismic attribute to assist in delineation of subsurface discontinuity interfaces and quantify the magnitude of the discontinuities, which further facilitates quantitative interpretation and stratigraphic interpretation.
Characterization of the novel mitochondrial genome replication factor MiRF172 in Trypanosoma brucei
Authors: Amodeo Simona , Jakob Martin , Ochsenreiter Torsten 
Published: April 2018

ABSTRACT
The unicellular parasite Trypanosoma brucei harbors one mitochondrial organelle with a singular genome called the kinetoplast DNA (kDNA). The kDNA consists of a network of concatenated minicircles and a few maxicircles that form the kDNA disc. More than 30 proteins involved in kDNA replication have been described. However, several mechanistic questions are only poorly understood. Here, we describe and characterize minicircle replication factor 172 (MiRF172), a novel mitochondrial genome replication factor that is essential for cell growth and kDNA maintenance. By performing super-resolution microscopy, we show that MiRF172 is localized to the kDNA disc, facing the region between the genome and the mitochondrial membranes. We demonstrate that depletion of MiRF172 leads to a loss of minicircles and maxicircles. Detailed analysis suggests that MiRF172 is involved in the reattachment of replicated minicircles to the kDNA disc. Furthermore, we provide evidence that the localization of the replication factor MiRF172 not only depends on the kDNA itself, but also on the mitochondrial genome segregation machinery, suggesting an interaction between the two essential entities.
This article has an associated First Person interview with the first author of the paper.
Based on the perceptions of community stakeholders, how can adolescent pregnancies be prevented? A qualitative study
Authors: Phuhongsai Sadudee , Pinitsoontorn Somdej 
Published: April 2018

Background: Adolescent pregnancy an important problem in adolescent health and government agencies need to focus on solving problem. The purpose of this research was to survey the perceptions of community stakeholders concerning the prevention of adolescent pregnancies in rural communities.Methods:Data collection was performed using group meetings with 103 stakeholders involved in adolescent pregnancy prevention. They were nurses, public health officials, parents or guardians, students, teachers, public health volunteers and community leaders. Thematic analysis indicated work on adolescent pregnancy prevention problems in rural areas was carried out by only some agencies such as district and sub-district health promoting hospitals, providing youth-friendly health service clinics and educating student leaders in schools on sex education.Results: Collectively, these results draw attention to the need for an appropriate program to strengthen adolescent, family and practitioner skills for the prevention of teenage pregnancies. Schools provide sex education as part of a health education curriculum, and some schools provide additional instruction in guidance classes. Problems from inconsistent work when networks fail were encountered. Stakeholders believe adolescent pregnancy prevention should focus on the following: (1) adolescents should receive training for skill development with content related to knowledge about sex, negotiation, refusal, morality and ethics, (2) teachers should receive training on comprehensive sexual education, and, (3) families should work to improve their communication on sexual health and developmentConclusions: There is a strong need for families to develop the ability to communicate with each other about sexuality and reproductive health. Developing parenting skills on how and when to talk about sex with their adolescents and open parental communication on sexuality issues at home is necessary. Activities need to also be developed for adolescents who are more inclined to engage in risky sexual behaviors.
Authoring Bioconductor workflows with BiocWorkflowTools
Authors: Smith Mike L. , Oleś Andrzej K. , Huber Wolfgang 
Published: April 2018

The Bioconductor Gateway on the F1000Research platform is a channel for peer-reviewed and citable publication of end-to-end data analysis workflows rooted in the Bioconductor ecosystem. In addition to the largely static journal publication, it is hoped that authors will also deposit their workflows as executable documents on Bioconductor, where the benefits of regular code testing and easy updating can be realized. Ideally these two endpoints would be met from a single source document. However, so far this has not been easy, due to lack of a technical solution that meets both the requirements of the F1000Research article submission format and the executable documents on Bioconductor. Submission to the platform requires a LaTeX file, which many authors traditionally have produced by writing an Rnw document for Sweave or knitr. On the other hand, to produce the HTML rendering of the document hosted by Bioconductor, the most straightforward starting point is the R Markdown format. Tools such as pandoc enable conversion between many formats, but typically a high degree of manual intervention used to be required to satisfactorily handle aspects such as floating figures, cross-references, literature references, and author affiliations. The BiocWorkflowTools package aims to solve this problem by enabling authors to work with R Markdown right up until the moment they wish to submit to the platform.
PERFILES DOCENTES UNIVERSITARIOS: CONOCIMIENTO Y USO PROFESIONAL DEL SMARTPHONE
Authors: Salcines Talledo Irina , González Fernández Natalia , Briones Pérez Elena 
Published: April 2018

INTRODUCCIÓN. La inmersión de las tecnologías de la información y la comunicación (TIC) en las aulas universitarias ha transformado las tradicionales dinámicas pedagógicas. Dispositivos móviles como el smartphone ofrecen múltiples posibilidades educativas para los docentes que se convierten en gestores, facilitadores y promotores de prácticas educativas de mobile learning mediadas por dispositivos como el smartphone. MÉTODO. El propósito de la investigación es ofrecer una clasificación de perfiles docentes relacionados con el conocimiento y uso de los smartphones, así como analizar su relación con el interés hacia la formación y el uso del dispositivo como recurso pedagógico en sus clases. Para ello se realizó un análisis de conglomerados, que permitió establecer perfiles y, mediante pruebas no parámetricas se analizó la significación respecto al interés hacia la formación y desarrollo de experiencias educativas. RESULTADOS. Los resultados indican la existencia de tres perfiles docentes denominados: impulsores del smartphone en tareas profesionales; iniciados profesionalmente en el smartphone y usuarios no profesionales del smartphone. El primer perfil es el que muestra un mayor interés hacia la formación y el que ha desarrollado más experiencias educativas con el smartphone. DISCUSIÓN. Esta clasificación de docentes en tres perfiles, al igual que en las investigaciones previas, no establece diferencias significativas relativas al género y se gradúa en función de la profundidad y habilidad en el uso y manejo de los recursos tecnológicos. Igualmente, los resultados permiten aventurar las características de una formación tecnológica dirigida a potenciar el uso profesional del smartphone en la educación superior para optimizar sus posibilidades educativas.
Ecotourism development to preserve mangrove conservation effort: Case study in Margasari Village, District of East Lampung, Indonesia
Authors: SETIAWAN WAWAN , HARIANTO SUGENG P. , QURNIATI ROMMY 
Published: April 2018

Setiawan W, Harianto SP, Rommy Qurniati R. 2017. Ecotourism development to preserve mangrove conservation effort: Case study in Margasari Village, District of East Lampung, Indonesia. Ocean Life 1: 14-19. The conservation efforts by Margasari community have produced the enhancement of mangrove forest areas, however the utilization of mangrove forest by people around was low. To make the conservation effort sustainable needs to develop mangrove ecotourism so they can utilize mangrove forest existence. This research intended to study the conservation and ecotourism effort in Margasari Village and the community perception of ecotourism development. This research was conducted in March-April 2017 in Margasari Village by interviewing 96 respondents. The data collection was undertaken through field observation, key informant interviews, and structured interviews with questionnaire. The result showed, the conservation effort was protecting, preserving, and utilizing of mangrove such as mangrove nursery, mangrove plantation, utilizing of jeruju and pedada fruit as food and counselling to the villagers not to cut mangrove and enter the mangrove forest. The ecotourism activities were boating around the mangrove, mangrove planting tourism, and bird watching. The conservation and ecotourism effort conduct by the people who joined community groups. But it was dominated by the group manager. So the financial benefit from ecotourism had limited for few people. Nevertheless, Margasari community agreed with the ecotourism development and was willing to participate in developing the ecotourism.
Using virtualization to protect the proprietary material science applications in volunteer computing
Authors: Khrapov Nikolay P. , Rozen Valery V. , Samtsevich Artem I. , Posypkin Mikhail A. , Sukhomlin Vladimir A. , Oganov Artem R. 
Published: April 2018

Abstract
USPEX is a world-leading software for computational material design. In essence, USPEX splits simulation into a large number of workunits that can be processed independently. This scheme ideally fits the desktop grid architecture. Workunit processing is done by a simulation package aimed at energy minimization. Many of such packages are proprietary and should be protected from unauthorized access when running on a volunteer PC. In this paper we present an original approach based on virtualization. In a nutshell, the proprietary code and input files are stored in an encrypted folder and run inside a virtual machine image that is also password protected. The paper describes this approach in detail and discusses its application in USPEX@home volunteer project.
A Miniaturized Dual-Band FSS with Closely Spaced Resonances Using 2.5-Dimension Structure
Authors: Yin Weiyang , Zhang Hou , Zhong Tao , Min Xueliang 
Published: April 2018

Abstract
Using 2.5-dimension structure, a novel miniaturized dual-band FSS with closely spaced resonances is proposed in the paper. The special design of the geometry contributes to two closely spaced resonances at 1.69 GHz and 2.16 GHz respectively and the frequency ratio of upper to the lower resonant frequency is 1.27. Besides, the two bands can be controlled individually by varying corresponding parameters. The size of the proposed FSS is only 0.057λ0, where the λ0 represents free space wavelength at lower resonant band. Furthermore, the simulation results show the proposed FSS exhibits stable response with different incident angles and polarizations. To understand the design better, the distribution of surface current is analyzed to explain the operating mechanism of the proposed FSS. Finally, the proposed FSS is fabricated and the measurement results are in accordance with the simulation results.
Existence results for semilinear neutral functional differential equations involving evolution operators in Fréchet spaces
Authors: Baghli Selma , Benchohra Mouffak 
Published: April 2018

Abstract
The existence of a unique mild solution on a semiinfinite interval for a first order semilinear neutral functional differential equations involving evolution operators in Fréchet spaces is investigating using a nonlinear alternative of Leray–Schauder type for contractive maps, combined with semigroup theory.
A Comparison of Simplified Two-dimensional Flow Models Exemplified by Water Flow in a Cavern
Authors: Prybytak Dzmitry , Zima Piotr 
Published: April 2018

Abstract
The paper shows the results of a comparison of simplified models describing a two-dimensional water flow in the example of a water flow through a straight channel sector with a cavern. The following models were tested: the two-dimensional potential flow model, the Stokes model and the Navier-Stokes model. In order to solve the first two, the boundary element method was employed, whereas to solve the Navier-Stokes equations, the open-source code library OpenFOAM was applied. The results of numerical solutions were compared with the results of measurements carried out on a test stand in a hydraulic laboratory. The measurements were taken with an ADV probe (Acoustic Doppler Velocimeter). Finally, differences between the results obtained from the mathematical models and the results of laboratory measurements were analysed.
Clinical analyses of 383 cases with maternal cardiac diseases
Authors: Aydin Emine , Ozyuncu Ozgur , Kasapoglu Dila , Orgul Gokcen , Ozer Necla , Yurdakok Murat , Beksac M. Sinan 
Published: April 2018

Abstract

Aim:
To evaluate the pregnancy outcomes of women with heart disease.

Materials and methods:
In this retrospective study, 383 pregnant women with cardiac diseases were examined. The cases were classified according to the World Health Organization (WHO) classification. The distribution of the cases according to class, congenital heart diseases, mean birthweight, mean gestational week at delivery, type of delivery [cesarean section (CS) or vaginal delivery], and cardivascular events (during pregnancy and puerperium) were evaluated.

Results:
Of the 383 patients, 25 were in Class I; 39, Class II; 255, Class II or III; 31, Class III; and 33, Class IV cardiac diseases. The neonatal birth weights were significantly lower in Class III than in Classes II, and II or III. The preterm delivery rate was higher in Class III than in the other classes. Delivery was performed by CS due to cardiac indications in the high-risk classes, however, only obstetric indications were considered in the low-risk classes. Only one case of maternal death occurred during the postpartum period, in a patient with Eisenmenger’s syndrome.

Discussion:
Cardiovascular diseases are an important cause of mortality and morbidity in pregnancy. The adverse impact of cardiovascular disorders on pregnancy outcomes should be the main concern during the management of these women.
Guest-driven unusual conformations in two calix[6]arene solvates and a new calix[8]arene
Authors: Martins Felipe Terra , da Silva Maia Angélica Faleiros , dos Santos Fernando Machado , Alvarenga Meiry Edivirges , Ribeiro Leandro , da Silva Neto Leonardo , de Fátima Ângelo 
Published: April 2018

Abstract
Unusual conformations have been found in a new calix[8]arene and in new solvates of two known calix[6]arenes. The chair-like conformation with 2/m point group symmetry was found for the first time in the dimethylformamide (DMF) disolvate of the basic calix[6]arene (1) without substituents in the lower and upper rims. Such symmetry is driven by the guest geometry allowing for two equivalent hydrogen bonding patterns in the chair seat. This avoids cone distortion found in the other chair-like conformers, although they have energies lower than that of new symmetrical conformer. The molecular conformation of hexa(carboxymethoxy)calix[6]arene (2) is also described as a dimethylsulfoxide (DMSO) pentasolvate. Its conformation can be described as a 1,3,5-closed cone with three alternate phenyl rings inclined inwards to the cone, thereby closing the cone entrance. Such a conformation also suggests five acid groups are pointed towards the same side of the calyx base and are able to bind metal ions or basic compounds in the lower rim, while inclusion of guests into the cone cavity is hindered. Both inclusion and cooperative acid binding/coordination abilities are still more hindered in the lowest energy 1,2,3-alternate cone conformer of 2. The role of the solvent in avoiding cone distortion was highlighted by inspecting the conformations of 5,11,17,23,29,35,41,47-octanitro-49,50,51,52,53,54,55,56-octa-n-butoxycalix[8]arene (3) and the known nitro analogues having methyl instead of n-butyl groups. Cone distortion is found in the non-solvated crystal form of 3, while non-classical hydrogen bonds with tetrahydrofuran preclude this in the literature analogue.