bluuebunny/crossref_metadata_2025_split huggingface dataset:
A retrieval-specific mechanism of adaptive forgetting in the mammalian brain
Authors: Bekinschtein Pedro , Weisstaub Noelia V. , Gallo Francisco , Renner Maria , Anderson Michael C. 
Published: November 2018

AbstractForgetting is a ubiquitous phenomenon that is actively promoted in many species. How and whether organisms’ behavioral goals drive which memories are actively forgotten is unknown. Here we show that processes essential to controlling goal-directed behavior trigger active forgetting of distracting memories that interfere with behavioral goals. When rats need to retrieve particular memories to guide exploration, it reduces later retention of other memories encoded in that environment. As with humans, this retrieval-induced forgetting is competition-dependent, cue-independent and reliant on prefrontal control: Silencing the medial prefrontal cortex with muscimol abolishes the effect. cFos imaging reveals that prefrontal control demands decline over repeated retrievals as competing memories are forgotten successfully, revealing a key adaptive benefit of forgetting. Occurring in 88% of the rats studied, this finding establishes a robust model of how adaptive forgetting harmonizes memory with behavioral demands, permitting isolation of its circuit, cellular and molecular mechanisms.
Dissipative shock waves generated by a quantum-mechanical piston
Authors: Mossman Maren E. , Hoefer Mark A. , Julien Keith , Kevrekidis P. G. , Engels P. 
Published: November 2018

AbstractThe piston shock problem is a prototypical example of strongly nonlinear fluid flow that enables the experimental exploration of fluid dynamics in extreme regimes. Here we investigate this problem for a nominally dissipationless, superfluid Bose-Einstein condensate and observe rich dynamics including the formation of a plateau region, a non-expanding shock front, and rarefaction waves. Many aspects of the observed dynamics follow predictions of classical dissipative—rather than superfluid dispersive—shock theory. The emergence of dissipative-like dynamics is attributed to the decay of large amplitude excitations at the shock front into turbulent vortex excitations, which allow us to invoke an eddy viscosity hypothesis. Our experimental observations are accompanied by numerical simulations of the mean-field, Gross-Pitaevskii equation that exhibit quantitative agreement with no fitting parameters. This work provides an avenue for the investigation of quantum shock waves and turbulence in channel geometries, which are currently the focus of intense research efforts.
Symmetry breakdown of electron emission in extreme ultraviolet photoionization of argon
Authors: Ilchen M. , Hartmann G. , Gryzlova E. V. , Achner A. , Allaria E. , Beckmann A. , Braune M. , Buck J. , Callegari C. , Coffee R. N. , Cucini R. , Danailov M. , De Fanis A. , Demidovich A. , Ferrari E. , Finetti P. , Glaser L. , Knie A. , Lindahl A. O. , Plekan O. , Mahne N. , Mazza T. , Raimondi L. , Roussel E. , Scholz F. , Seltmann J. , Shevchuk I. , Svetina C. , Walter P. , Zangrando M. , Viefhaus J. , Grum-Grzhimailo A. N. , Meyer M. 
Published: November 2018

AbstractShort wavelength free-electron lasers (FELs), providing pulses of ultrahigh photon intensity, have revolutionized spectroscopy on ionic targets. Their exceptional photon flux enables multiple photon absorptions within a single femtosecond pulse, which in turn allows for deep insights into the photoionization process itself as well as into evolving ionic states of a target. Here we employ ultraintense pulses from the FEL FERMI to spectroscopically investigate the sequential emission of electrons from gaseous, atomic argon in the neutral as well as the ionic ground state. A pronounced forward-backward symmetry breaking of the angularly resolved emission patterns with respect to the light propagation direction is experimentally observed and theoretically explained for the region of the Cooper minimum, where the asymmetry of electron emission is strongly enhanced. These findings aim to originate a better understanding of the fundamentals of photon momentum transfer in ionic matter.
A study of fractal dimension as a quality indicator of hairtail (Trichiurus haumela) samples during frozen storage
Authors: Luan Lanlan , Sun Yeshun , Chen Shiguo , Wu Chunhua , Hu Yaqin 
Published: November 2018

AbstractHairtail fish samples were stored at different freezing temperatures of −5 °C, −20 °C, −40 °C and −80 °C. To establish an effective quality evaluation approach for hairtail samples during frozen storage, fractal dimension was used to observe the porous microstructure that resulted from the ice crystal formation in frozen hairtail meat. The results showed that the initial value of fractal dimension of all the samples was 1.968. After frozen storage, the fractal dimension of samples at −5 °C, −20 °C, −40 °C and −80 °C decreased to 1.539, 1.682, 1.856 and 1.896, respectively. Traditional quality indicators such as water activity, color and textural properties (i.e., hardness, springiness and chewiness) also exhibited a similar decreasing trend, and the rate of change decreased with a decrease in storage temperature. The relationships were analyzed, and these traditional quality indicators were correlated with the fractal dimension with determined correlation coefficients within ±0.900. Moreover, based on the fractal dimension model, the first-order kinetic equation of fractal dimension variation during storage was$${{\bf{d}}}_{{\bf{t}}}={\bf{1.968}}\,{{\bf{e}}}^{{\boldsymbol{-}}{\bf{0.928}}{\bf{t}}{{\bf{e}}}^{{\boldsymbol{-}}{\bf{1431.396}}/{\bf{T}}}}$$dt=1.968e−0.928te−1431.396/T, which can be used to predict the shelf life of preserved hairtails at different storage temperatures. The results demonstrated fractal dimension was a novel and feasible method to evaluate the quality of hairtails in frozen storage.
Sensory prediction errors, not performance errors, update memories in visuomotor adaptation
Authors: Lee Kangwoo , Oh Youngmin , Izawa Jun , Schweighofer Nicolas 
Published: November 2018

AbstractSensory prediction errors are thought to update memories in motor adaptation, but the role of performance errors is largely unknown. To dissociate these errors, we manipulated visual feedback during fast shooting movements under visuomotor rotation. Participants were instructed to strategically correct for performance errors by shooting to a neighboring target in one of four conditions: following the movement onset, the main target, the neighboring target, both targets, or none of the targets disappeared. Participants in all conditions experienced a drift away from the main target following the strategy. In conditions where the main target was shown, participants often tried to minimize performance errors caused by the drift by generating corrective movements. However, despite differences in performance during adaptation between conditions, memory decay in a delayed washout block was indistinguishable between conditions. Our results thus suggest that, in visuomotor adaptation, sensory predictions errors, but not performance errors, update the slow, temporally stable, component of motor memory.
High energy oxidation and organosolv solubilization for high yield isolation of cellulose nanocrystals (CNC) from Eucalyptus hardwood
Authors: Zhang Renli , Liu Yun 
Published: November 2018

AbstractCellulose nanocrystals (CNC) have been widely used as responsive materials, chiral templates, and tough nano-composites due to its unparalleled properties. Acid and enzyme hydrolyses are extensively employed to prepare CNC. These traditional approaches exhibit inherent limitations of corrosion hazards, time-consuming process, and/or low yield. Herein, irradiation oxidation and organosolv solubilization are conducted to cause rapid degradation with simultaneous crystallization of cellulose to achieve approx. 87% yield of CNC. The morphology, spectroscopic, and stability properties of the as-prepared CNC are characterized through UV-vis spectroscopy, zetal potential, XRD, TEM, DLS, GPC, FT-IR and TGA techniques. The resultant CNC suspension presents unique property with high stability after 9 months storage at 4 °C. Moreover, CNC liquid crystal phase is successfully generated by addition of anions or cations solution to the CNC aqueous dispersion without stirring. The innovative approach in this work opens an avenue to obtain CNC directly from lignocellulosic biomass through irradiation oxidation and organosolv solubilization without acid hydrolysis and washing procedure.
MRI-guided intrathecal transplantation of hydrogel-embedded glial progenitors in large animals
Authors: Malysz-Cymborska Izabela , Golubczyk Dominika , Kalkowski Lukasz , Burczyk Adam , Janowski Miroslaw , Holak Piotr , Olbrych Katarzyna , Sanford Joanna , Stachowiak Kalina , Milewska Kamila , Gorecki Przemysław , Adamiak Zbigniew , Maksymowicz Wojciech , Walczak Piotr 
Published: November 2018

AbstractDisseminated diseases of the central nervous system such as amyotrophic lateral sclerosis (ALS) require that therapeutic agents are delivered and distributed broadly. Intrathecal route is attractive in that respect, but to date there was no methodology available allowing for optimization of this technique to assure safety and efficacy in a clinically relevant setting. Here, we report on interventional, MRI-guided approach for delivery of hydrogel-embedded glial progenitor cells facilitating cell placement over extended surface of the spinal cord in pigs and in naturally occurring ALS-like disease in dogs. Glial progenitors used as therapeutic agent were embedded in injectable hyaluronic acid-based hydrogel to support their survival and prevent sedimentation or removal. Intrathecal space was reached through lumbar puncture and the catheter was advanced under X-ray guidance to the cervical part of the spine. Animals were then transferred to MRI suite for MRI-guided injection. Interventional and follow-up MRI as well as histopathology demonstrated successful and predictable placement of embedded cells and safety of the procedure.
Effects of CRISPR/Cas9 dosage on TICAM1 and RBL gene mutation rate, embryonic development, hatchability and fry survival in channel catfish
Authors: Elaswad Ahmed , Khalil Karim , Ye Zhi , Liu Zhanjiang , Liu Shikai , Peatman Eric , Odin Ramjie , Vo Khoi , Drescher David , Gosh Kamal , Qin Guyu , Bugg William , Backenstose Nathan , Dunham Rex 
Published: November 2018

AbstractThe current study was conducted to assess the effects of microinjection of different dosages of guide RNA (gRNA)/Cas9 protein on the mutation rate, embryo survival, embryonic development, hatchability and early fry survival in channel catfish, Ictalurus punctatus. Guide RNAs targeting two of the channel catfish immune-related genes, toll/interleukin 1 receptor domain-containing adapter molecule (TICAM 1) and rhamnose binding lectin (RBL) genes, were designed and prepared. Three dosages of gRNA/Cas9 protein (low, 2.5 ng gRNA/7.5 ng Cas9, medium, 5 ng gRNA/15 ng Cas9 and high, 7.5 ng gRNA/22.5 ng Cas9) were microinjected into the yolk of one-cell embryos. Mutation rate increased with higher dosages (p < 0.05). Higher dosages increased the mutation frequency in individual embryos where biallelic mutations were detected. For both genes, microinjection procedures increased the embryo mortality (p < 0.05). Increasing the dosage of gRNA/Cas9 protein increased the embryo mortality and reduced the hatching percent (p < 0.05). Embryonic development was delayed when gRNAs targeting RBL gene were injected. Means of fry survival time were similar for different dosages (p > 0.05). The current results lay the foundations for designing gene editing experiments in channel catfish and can be used as a guide for other fish species.
Proton minibeam radiation therapy widens the therapeutic index for high-grade gliomas
Authors: Prezado Yolanda , Jouvion Gregory , Patriarca Annalisa , Nauraye Catherine , Guardiola Consuelo , Juchaux Marjorie , Lamirault Charlotte , Labiod Dalila , Jourdain Laurene , Sebrie Catherine , Dendale Remi , Gonzalez Wilfredo , Pouzoulet Frederic 
Published: November 2018

AbstractProton minibeam radiation therapy (pMBRT) is a novel strategy which has already shown a remarkable reduction in neurotoxicity as to compared with standard proton therapy. Here we report on the first evaluation of tumor control effectiveness in glioma bearing rats with highly spatially modulated proton beams. Whole brains (excluding the olfactory bulb) of Fischer 344 rats were irradiated. Four groups of animals were considered: a control group (RG2 tumor bearing rats), a second group of RG2 tumor-bearing rats and a third group of normal rats that received pMBRT (70 Gy peak dose in one fraction) with very heterogeneous dose distributions, and a control group of normal rats. The tumor-bearing and normal animals were followed-up for 6 months and one year, respectively. pMBRT leads to a significant tumor control and tumor eradication in 22% of the cases. No substantial brain damage which confirms the widening of the therapeutic window for high-grade gliomas offered by pMBRT. Additionally, the fact that large areas of the brain can be irradiated with pMBRT without significant side effects, would allow facing the infiltrative nature of gliomas.
Evolution of six novel ORFs in the plastome of Mankyua chejuense and phylogeny of eusporangiate ferns
Authors: Kim Hyoung Tae , Kim Ki-Joong 
Published: November 2018

AbstractIn this paper, three plastomes of Mankyua chejuense, Helminthostachys zeylanica, and Botrychium ternatum in Ophioglossaceae were completely sequenced in order to investigate the plastome evolution and phylogeny of eusporangiate ferns. They were similar to each other in terms of length and the gene orders; however, six unknown open reading frames (ORFs) were found between rps4 and trnL-UAA genes in M. chejuense. Similar sequence regions of six ORFs of M. chejuense were found at the plastomes of Ophioglossum californicum and H. zeylanica, as well as the mitochondrial genome (mitogenome) of H. zeylanica, but not in B. ternatum. Interestingly, the translated amino acid sequences of three ORFs were more similar to the proteins of distantly related taxa such as algae and bacteria than they were to proteins in land plants. It is likely that the six ORFs region arose from endosymbiotic gene transfer (EGT) or horizontal gene transfer (HGT), but further study is needed to verify this. Phylogenetic analyses suggested that Mankyua was resolved as the earliest diverging lineage and that Ophioglossum was subsequently diverged in Ophioglossaceae. This result supports why the plastome of M. chejuense have contained the most ancestral six ORFs in the family.
A Deep Neural Network Model using Random Forest to Extract Feature Representation for Gene Expression Data Classification
Authors: Kong Yunchuan , Yu Tianwei 
Published: November 2018

AbstractIn predictive model development, gene expression data is associated with the unique challenge that the number of samples (n) is much smaller than the amount of features (p). This “n ≪ p” property has prevented classification of gene expression data from deep learning techniques, which have been proved powerful under “n > p” scenarios in other application fields, such as image classification. Further, the sparsity of effective features with unknown correlation structures in gene expression profiles brings more challenges for classification tasks. To tackle these problems, we propose a newly developed classifier named Forest Deep Neural Network (fDNN), to integrate the deep neural network architecture with a supervised forest feature detector. Using this built-in feature detector, the method is able to learn sparse feature representations and feed the representations into a neural network to mitigate the overfitting problem. Simulation experiments and real data analyses using two RNA-seq expression datasets are conducted to evaluate fDNN’s capability. The method is demonstrated a useful addition to current predictive models with better classification performance and more meaningful selected features compared to ordinary random forests and deep neural networks.
Structural effects and lymphocyte activation properties of self-assembled polysaccharide nanogels for effective antigen delivery
Authors: Miura Risako , Tahara Yoshiro , Sawada Shin-ichi , Sasaki Yoshihiro , Akiyoshi Kazunari 
Published: November 2018

AbstractThe success of immunotherapeutic vaccines is often limited by their inability to activate the cytotoxic T lymphocyte (CTL)-inducing Th1 pathway. We investigated the ability of self-assembled nanogels (CHP or CH-CDex) to activate this pathway, and characterised them chemically and biologically. Once loaded with antigen (ovalbumin, OVA) their OVA encapsulation and dissociation rates suggested the possibility of effective antigen delivery. The DC2.4 dendritic cell line took up either vaccine time-dependently, but both vaccines required CpG DNA for class I MHC presentation. The nanogel vaccines interacted with RAW264.7, a Balb/c mouse-derived macrophage cell line, and co-localised with lysosomes, suggesting their endocytotic internalization in RAW264.7. Both vaccines activated CTLs better than OVA alone. Unlike OVA alone, the nanogel vaccines induced IgG2a antibody production in mice, whereas the former induced IgG1 antibodies. OVA-nanogel delivery to the draining lymph nodes (DLNs) was higher than that for OVA alone, reaching a deeper medullary area. Furthermore, Langerin+CD103+DCs interacted with the nanogel vaccines effectively, which is a subset of cross-presentation DC, in the DLNs. The nanogel vaccines each had good anti-tumour efficacy in OVA tumour-bearing mice compared with the OVA alone. Thus, CHP and CH-CDex nanogels should be investigated further because of the great potential they offer for immunotherapy.
Yeast thioredoxin reductase Trr1p controls TORC1-regulated processes
Authors: Picazo Cecilia , Matallana Emilia , Aranda Agustín 
Published: November 2018

AbstractThe thioredoxin system plays a predominant role in the control of cellular redox status. Thioredoxin reductase fuels the system with reducing power in the form of NADPH. The TORC1 complex promotes growth and protein synthesis when nutrients, particularly amino acids, are abundant. It also represses catabolic processes, like autophagy, which are activated during starvation. We analyzed the impact of yeast cytosolic thioredoxin reductase TRR1 deletion under different environmental conditions. It shortens chronological life span and reduces growth in grape juice fermentation. TRR1 deletion has a global impact on metabolism during fermentation. As expected, it reduces oxidative stress tolerance, but a compensatory response is triggered, with catalase and glutathione increasing. Unexpectedly, TRR1 deletion causes sensitivity to the inhibitors of the TORC1 pathway, such as rapamycin. This correlates with low Tor2p kinase levels and indicates a direct role of Trr1p in its stability. Markers of TORC1 activity, however, suggest increased TORC1 activity. The autophagy caused by nitrogen starvation is reduced in the trr1Δ mutant. Ribosomal protein Rsp6p is dephosphorylated in the presence of rapamycin. This dephosphorylation diminishes in the TRR1 deletion strain. These results show a complex network of interactions between thioredoxin reductase Trr1p and the processes controlled by TOR.
How Gender Stereotypes May Limit Female Faculty Advancement in Communication Sciences and Disorders
Authors: Rogus-Pulia Nicole , Humbert Ianessa , Kolehmainen Christine , Carnes Molly 
Published: November 2018

Purpose
The field of communication sciences and disorders (CSD) faces a critical shortage of the faculty essential to train the future workforce of speech-language pathologists and audiologists. Despite a predominance of women in the field, men receive doctoral degrees, tenure status, academic leadership positions, and American Speech-Language-Hearing Association awards at disproportionately higher rates than women. The purpose of this review is to explore how implicit gender bias may contribute to female faculty advancement, including current and projected faculty workforce shortages, and to propose tangible solutions.

Method
The authors present proportions of men and women who receive doctoral degrees, advance to each faculty rank, receive tenure status, hold department chairs in CSD, and receive American Speech-Language-Hearing Association honors and awards. They review ways in which cultural stereotypes give rise to implicit gender bias and discuss myriad ways that implicit gender bias may influence the decisions of students considering an academic career in CSD and their career trajectories.

Conclusions
Cultural stereotypes about men and women lead to implicit gender bias that may have real consequences for female faculty advancement in CSD. Such implicit bias can influence career selection and outcomes within the field in multiple ways. To ensure that CSD continues to attract top talent and maintain a robust pipeline of future faculty in doctoral training programs, the field must recognize the existence of implicit gender bias and implement evidence-based strategies to minimize its potentially damaging effects on the future of the profession.
The Dimensionality of Oral Language in Kindergarten Spanish–English Dual Language Learners
Authors: Gray Shelley , O'Connell Ann A. , Restrepo Maria Adelaida , Yeomans-Maldonado Gloria , Bengochea Alain , Mesa Carol , Brinkley Shara , Yeomans-Maldonado Gloria , Bengochea Alain , Mesa Carol 
Published: November 2018

Purpose
The purpose of this study was to examine the latent dimensionality of language in dual language learners (DLLs) who spoke Spanish as their native language and were learning English as their second language.

Method
Participants included 259 Spanish–English DLLs attending kindergarten. In the spring of their kindergarten year, children completed vocabulary, grammar, listening comprehension, and higher level language measures (comprehension monitoring and inferencing) in Spanish and English.

Results

Two models with similar fits best describe the data. The first was a bifactor model with a single general language factor “
l,
” plus 2 additional language factors, 1 for Spanish and 1 for English. The second model was a 4-factor model, 1 for English that included all English language measures and 3 additional factors that included Spanish vocabulary, Spanish grammar, and Spanish higher level language.

Conclusions
These results indicate that a general language ability may underlie development in both Spanish and English. In contrast to a unidimensional structure found for monolingual English-speaking kindergarteners, oral language appears to be multidimensional in Spanish–English DLL kindergarteners, but multidimensionality is reflected in Spanish, not English.