bluuebunny/crossref_metadata_2025_split huggingface dataset:
Treatment of oral cancers during pregnancy: A case-based discussion
Authors: Sato Kiyoshi , Shimamoto Hiroaki , Mochizuki Yumi , Hirai Hideaki , Tomioka Hirofumi , Shimizu Risa , Marukawa Eriko , Fukayama Haruhisa , Yoshimura Ryoichi , Ishida Hiroo , Harada Hiroyuki 
Published: February 2019

Background Malignancies occur in approximately 1:1000 pregnancies; the most common being breast (46%) and hematological (18%) malignancies. Oral cancers account for only 2% of all cancers in pregnant women, and there are no standard guidelines for the treatment of oral cancer during pregnancy. Methods Between 2007 and 2014, our department managed 1109 patients with oral cancers; four (0.4%) had tongue carcinomas during pregnancy. These cases were retrospectively reviewed. Results The four women were aged 29–39 (median 32.5) years. Two underwent partial glossectomy at 39 and 40 weeks’ gestation, respectively, one received radiotherapy at 17 weeks’ gestation, and one underwent supraomohyoid neck dissection and hemi-glossectomy with a forearm flap reconstruction. Conclusion In addition to tumor factors, the wishes of the patient and her family, gestational age, and fetal and maternal conditions are important factors in deciding on a treatment protocol. Moreover, treatment decisions require multidisciplinary approach.
RETRACTED ARTICLE: Predictability and controlling factors of overpressure in the North Alpine Foreland Basin, SE Germany: an interdisciplinary post-drill analysis of the Geretsried GEN-1 deep geothermal well
Authors: Drews Michael C. , Hofstetter Peter , Zosseder Kai , Straubinger Robert , Gahr Andreas , Stollhofen Harald 
Published: February 2019

AbstractFor the first time, drilling- and velocity-based well analysis and 3D basin modeling were combined to test the predictability and controlling factors of overpressure in the North Alpine Foreland Basin in SE Germany. More specifically, the techniques were tested in the sub-regional context of the deep geothermal well Geretsried GEN-1 (TVD = 4852 m), located in the south of Munich. A 3D basin model based on a total of 20 wells was calibrated to the pressure distribution of four petroleum wells and tested against the Geretsried GEN-1 well. The results demonstrate that overpressure in the North Alpine Foreland Basin SE Germany can be predicted from a simple 3D basin model calibrated to a minimum number of wells. Thereby, disequilibrium compaction likely acts as the main overpressure mechanism in the study area, underpinned by significantly higher sedimentation rates at overpressured locations. 3D basin modeling also confirms the role of Upper Cretaceous shales, which, if present, serve as an important pressure barrier between the under- to normally pressured Jurassic and overpressured Cenozoic basin fill. In addition, overpressure magnitudes of the Chattian might be higher than previously expected. The results of this study have great impact on future drilling campaigns in the North Alpine Foreland Basin in SE Germany. Minimized non-productive time and drilling cost, improved well planning and increased safety are amongst the most important benefits of accurate pore pressure and overpressure prediction. The newly derived insights on the mechanisms of overpressure will greatly influence future geomechanical and tectonic studies, since pore pressure drives rock strength and principle stress magnitudes. Finally, the study is a great example for the importance of an interdisciplinary approach and the incorporation of geological conditions, when investigating drilling-related problems.
Enhanced peer-review for optimising publication of biomedical papers submitted from low- and middle-income countries: feasibility study for a randomised controlled trial
Authors: Pitman Alexandra , Underwood Raphael , Hamilton Adam , Tyrer Peter , Yang Min 
Published: February 2019

BackgroundBiomedical research from low- and middle-income countries (LMICs) is poorly represented in Western European and North American psychiatric journals.AimsTo test the feasibility of trialling a capacity-building intervention to improve LMIC papers' representation in biomedical journals.MethodWe designed an enhanced peer-review intervention delivered to LMIC corresponding/first authors of papers rejected by the British Journal of Psychiatry. We conducted a feasibility study, inviting consenting authors to be randomised to intervention versus none, measuring recruitment and retention rates, outcome completion and author/reviewer-rated acceptability.ResultsOf the 26/121 consenting to participate, 12 were randomised to the intervention and 14 to the control arms. Outcome completion was 100% but qualitative feedback from authors/reviewers was mixed, with attrition from 5/12 (42%) of intervention reviewers.ConclusionsLow interest among eligible authors and variable participation of expert reviewers suggested low feasibility of a full trial and a need for intervention redesign.Declaration of interestA.P., P.T. and M.Y. are British Journal of Psychiatry editorial board members. During this study P.T. was British Journal of Psychiatry Editor, A.P. was a trainee editor and A.H. was an editorial assistant.
Discrediting experiences: outcomes of eligibility assessments for claimants with psychiatric compared with non-psychiatric conditions transferring to personal independence payments in England
Authors: Pybus Katie , Pickett Kate E. , Prady Stephanie L. , Lloyd Charlie , Wilkinson Richard 
Published: February 2019

BackgroundRecent qualitative research suggests that changes to the way eligibility for welfare payments is determined in the UK may be detrimental to claimants with mental illnesses. No large-scale analysis has been undertaken to date.AimsTo examine differences between claimants with psychiatric conditions compared with non-psychiatric conditions in the number of claims disallowed following a personal independence payment (PIP) eligibility assessment for existing disability living allowance (DLA) claimants.MethodAdministrative data on DLA claimants with psychiatric conditions transferring to PIP between 2013 and 2016 was compared with claimants with non-psychiatric conditions to explore differences in the number of claims disallowed following an eligibility assessment.ResultsClaimants with a mental illness were 2.40 (95% CI 2.36–2.44) times more likely to have their existing DLA entitlement removed following a PIP eligibility assessment than claimants with musculoskeletal conditions, neurological conditions and diabetes.ConclusionsPIP eligibility assessment outcomes show marked differences by health condition, raising questions as to whether the process is equitable.Declaration of interestNone.
Buparlisib in Patients With Recurrent Glioblastoma Harboring Phosphatidylinositol 3-Kinase Pathway Activation: An Open-Label, Multicenter, Multi-Arm, Phase II Trial
Authors: Wen Patrick Y. , Touat Mehdi , Alexander Brian M. , Mellinghoff Ingo K. , Ramkissoon Shakti , McCluskey Christine S. , Pelton Kristine , Haidar Sam , Basu Sankha S. , Gaffey Sarah C. , Brown Loreal E. , Martinez-Ledesma Juan Emmanuel , Wu Shaofang , Kim Jungwoo , Wei Wei , Park Mi-Ae , Huse Jason T. , Kuhn John G. , Rinne Mikael L. , Colman Howard , Agar Nathalie Y.R. , Omuro Antonio M. , DeAngelis Lisa M. , Gilbert Mark R. , de Groot John F. , Cloughesy Timothy F. , Chi Andrew S. , Roberts Thomas M. , Zhao Jean J. , Lee Eudocia Q. , Nayak Lakshmi , Heath James R. , Horky Laura L. , Batchelor Tracy T. , Beroukhim Rameen , Chang Susan M. , Ligon Azra H. , Dunn Ian F. , Koul Dimpy , Young Geoffrey S. , Prados Michael D. , Reardon David A. , Yung W.K. Alfred , Ligon Keith L. 
Published: February 2019

PURPOSE Phosphatidylinositol 3-kinase (PI3K) signaling is highly active in glioblastomas. We assessed pharmacokinetics, pharmacodynamics, and efficacy of the pan-PI3K inhibitor buparlisib in patients with recurrent glioblastoma with PI3K pathway activation. METHODS This study was a multicenter, open-label, multi-arm, phase II trial in patients with PI3K pathway–activated glioblastoma at first or second recurrence. In cohort 1, patients scheduled for re-operation after progression received buparlisib for 7 to 13 days before surgery to evaluate brain penetration and modulation of the PI3K pathway in resected tumor tissue. In cohort 2, patients not eligible for re-operation received buparlisib until progression or unacceptable toxicity. Once daily oral buparlisib 100 mg was administered on a continuous 28-day schedule. Primary end points were PI3K pathway inhibition in tumor tissue and buparlisib pharmacokinetics in cohort 1 and 6-month progression-free survival (PFS6) in cohort 2. RESULTS Sixty-five patients were treated (cohort 1, n = 15; cohort 2, n = 50). In cohort 1, reduction of phosphorylated AKTS473 immunohistochemistry score was achieved in six (42.8%) of 14 patients, but effects on phosphoribosomal protein S6S235/236 and proliferation were not significant. Tumor-to-plasma drug level was 1.0. In cohort 2, four (8%) of 50 patients reached 6-month PFS6, and the median PFS was 1.7 months (95% CI, 1.4 to 1.8 months). The most common grade 3 or greater adverse events related to treatment were lipase elevation (n = 7 [10.8%]), fatigue (n = 4 [6.2%]), hyperglycemia (n = 3 [4.6%]), and elevated ALT (n = 3 [4.6%]). CONCLUSION Buparlisib had minimal single-agent efficacy in patients with PI3K-activated recurrent glioblastoma. Although buparlisib achieved significant brain penetration, the lack of clinical efficacy was explained by incomplete blockade of the PI3K pathway in tumor tissue. Integrative results suggest that additional study of PI3K inhibitors that achieve more-complete pathway inhibition may still be warranted.
Thermal Lens Microscope and Microchip Chemistry
Authors: Kitamori Takehiko 
Published: February 2019

Abstract
Thermal lens spectrometry was realized under an optical microscope by controlling the chromatic aberration of the objective lens system. This thermal lens microscope (TLM) is ultrasensitive to non-fluorescent molecules and detection at even the yoctomole level in a liquid was confirmed. The TLM is widely applicable, almost the same as spectrophotometry, but its specificity for the analyte species is similarly poor. During development of the TLM equipment, a microchannel fabricated on a glass substrate was used as a sample vessel, which then became a microchemical chip. The generalized microchemical chip design method, micro unit operation (MUO) and continuous flow chemical processing (CFCP) was proposed and a variety of complex chemical processes for analyses, syntheses, and biomedical experiments could be integrated onto the microchemical chip. Therefore, the development of microchemical chips realized significant expansion of the field of microfluidics. Microchemical chips are also suitable devices for separation chemistry, and combination of the TLM and microchemical chips could compensate for the poor selectivity of TLM. These innovative methods will not only impact analytical chemistry but also microfluidics and most certainly other research fields such as biology and medicine. This account of The Chemical Society of Japan Award for Creative Work 2006 introduces these achievements.
Evaluation of a multi-level intervention to improve postpartum intrauterine device services in Rwanda
Authors: Ingabire Rosine , Nyombayire Julien , Hoagland Alexandra , Da Costa Vanessa , Mazzei Amelia , Haddad Lisa , Parker Rachel , Sinabamenye Robertine , Mukamuyango Jeannine , Smith Julie , Umutoni Victoria , Mork Ellen , Allen Susan , Karita Etienne , Wall Kristin M. 
Published: February 2019

Background. The copper intrauterine device is one of the most safe, effective, and cost-effective methods for preventing unintended pregnancy. It can be used postpartum irrespective of breastfeeding to improve birth spacing and reduce unintended pregnancy and maternal-child mortality. However, this method remains highly underutilized. Methods. We developed a multi-level intervention to increase uptake of the postpartum intrauterine device (PPIUD, defined as insertion up to six weeks post-delivery) in Kigali, Rwanda. High-volume hospitals and health centers were selected for implementation of PPIUD counseling and service delivery. Formative work informed development of a PPIUD counseling flipchart to be delivered during antenatal care, labor and delivery, infant vaccination visits, or in the community. Two-day didactic counseling, insertion/removal, and follow-up trainings were provided to labor and delivery and family planning nurses followed by a mentored practicum certification process. Counseling data were collected in government clinic logbooks. Insertions and follow-up data were collected in logbooks created for the implementation. Data were collected by trained government clinic staff and abstracted/managed by study staff. Stakeholders were involved from intervention development through dissemination of results. Results. Two hospitals (and their two associated health centers) and two additional health centers were selected. In 6-months prior to our intervention, 7.7 PPIUDs/month were inserted on average at the selected facilities. From August 2017-July 2018, we trained 83 counselors and 39 providers to provide PPIUD services. N=9,020 women received one-on-one PPIUD counseling after expressing interest in family planning who later delivered at a selected health facility. Of those, n=2,575 had PPIUDs inserted (average of 214.6 insertions/month), a 29% uptake. Most PPIUDs (62%) were inserted within 10 minutes of delivery of the placenta. Conclusions. This successful, comprehensive intervention has the potential to make a significant impact on PPIUD uptake in Rwanda. The intervention is scalable and adaptable to other sub-Saharan African countries.
¿Qué saben los estudiantes secundarios de la última dictadura? Fortalezas y debilidades de la formación de ciudadanos en las clases de Historia de escuelas secundarias de la ciudad de La Plata
Authors: De Amézola Gonzalo 
Published: February 2019

Este trabajo se ocupa de cómo los alumnos de la escuela secundaria conocen e interpretan el tema de la última dictadura militar argentina, un contenido considerado central para su formación como ciudadanos democráticos. Con este propósito se utilizan datos cuantitativos resultantes de una investigación terminada sobre los países del Mercosur y se los contrapone con los obtenidos mediante narrativas de estudiantes de 5º año de un proyecto cualitativo todavía en curso y focalizado en la ciudad de La Plata (capital de la Provincia de Buenos Aires).
Considerations for the Postpartum Runner
Authors: Mihevc Edwards Kate 
Published: February 2019

ABSTRACT
Today, there are over 35 million runners in the United States and greater than half are women. The psychological, physiological, and biomechanical differences between male and female runners are well cited; however, there is little guidance provided to health care providers including running and strength coaches about how to transition runners back to running postpartum. This article can serve as a reference for understanding the unique challenges female runners face postpartum and give clinicians the knowledge to manage the athlete's expectations and training progression.
What Drives the Perception of School Principals as Professional Managers in Small European Countries? The Case of Croatia/Što oblikuje percepciju školskih ravnatelja kao profesionalnih menadžera u malim europskim državama? Slučaj Hrvatske
Authors: Alfirevic Niksa , Vican Dijana , Pavičić Jurica 
Published: February 2019

AbstractIn this study, the authors discuss the educational and social factors that contribute to the perception of school principals as an independent managerial profession. Empirical results are based on a household survey, nationally representative of the Republic of Croatia as a small European country involved in a comprehensive educational reform. The empirical results indicate that trust in individual social actors relevant for education and the public perception of school effectiveness can serve as predictors of the public assessment of principalship as a profession. Potential implications for further research and policy development in small European countries are suggested. The proposed policy interventions emphasize institutional capacity building and an attempt to achieve a positive feedback loop by strengthening mutual links between the development of local resources and the communication of positive local narratives.Key words: Croatia; educational management; predictors; profession; school principals. --- SažetakU ovom se radu istražuju obrazovni i društveni faktori koji pridonose percepciji školskih ravnatelja kao neovisne menadžerske profesije. Empirijski su rezultati dobiveni ispitivanjem kućanstava reprezentativnih za Republiku Hrvatsku, malu europsku država koja provodi opsežnu reformu obrazovanja. Empirijski rezultati sugeriraju da povjerenje u pojedine društvene aktere koji su relevantni za obrazovanje i javna percepcija učinkovitosti škola mogu služiti kao čimbenici prognoze javne procjene ravnateljske profesije. Iznose se moguće implikacije za buduća istraživanja i razvoj politika u malim europskim državama. Predložene intervencije u politiku naglašavaju sposobnost institucionalne izgradnje, kao i pokušaj kreiranja pozitivnih povratnih informacija jačanjem međusobnih poveznica između razvoja lokalnih resursa i dijeljenja pozitivnih lokalnih narativa.Ključni pojmovi: Hrvatska; obrazovni menadžment; prediktorske varijable; profesija; školski ravnatelji.
Pediatri Polikliniğinden Ortopedi Bölümüne Danışılan 0-3 Yaş Arası Ardışık 100 Hastanın Analizi
Authors: ÖZTÜRK Recep , GENÇOĞLU Murat Yasin , ATEŞ Ömer Faruk , AYTEKİN Mahmut Nedim , TOKTAŞ Orçun 
Published: February 2019

Amaç : Bu çalışmada, 0-3 yaş arası erken çocukluk döneminde çocuk polikliniğinden
ortopedi polikliniğine danışılan hastaların demografik verilerinin analizi amaçlandı. Gereç ve Yöntem : 2017- 2018 yılları arasında, çocuk polikliniğinden ortopedi
polikliniğine konsulte edilen hastalar içinden, 0 ile 3 yaş arası yaşları olan ardışık
yüz hastanın, yaşları, klinik bulguları ve ortopedik inceleme sonuçları retrospektif
olarak incelendi. Bulgular : Yaşları 1 ay ile 36 ay arası değişen, ortalama yaşları 17 ay olan
100 çocuk hastanın 54 ü kız, 46 sı erkek hasta idi. 14 farklı ön tanı ile hastalar
ortopedi kliniğine danışıldı. En sık danışılma nedeni gelişimsel kalça displazisi
ön tanısı idi (44 hasta). Danışılan hastaların 14 ünde gelişimsel kalça displazisi
saptandı. İkinci en sık ön tanı, içe basma idi (25 hasta). Diğer daha nadir ön tanılar,
doğumsal klavikula kırığı (9 hasta), tortikollis (4 hasta), pes equinovarus (4 hasta),
o-bone (3 hasta), eklemlerden ses gelmesi(2 hasta), eklemlerde spastisite(2 hasta),
planovalgus, sellülit, parmak ucunda yürüme, sakral kıllanma, polidaktili, tetik
parmak ve brakial pleksus hasarı idi.

Sonuç: Çocuk hastalıkları kliniklerindeki 0-3 yaş arası erken çocukluk muayenelerinde
en sık rastlanılan ortopedik patolojiler
gelişimsel kalça displazisi ve içe basma olmakla birlikte, klinisyenin en az ondan
fazla sık görülen ortopedik patoloji hakkında şüpheci olması önemlidir.
Rheological Behavior of the Composites of Carboxymethylcellulose-Zinc Oxide/Starch
Authors: Coutinho Marcio Da Silva , Da Silva Danielle Cristina Fernandes , Xavier Gustavo Ribeiro , Rumjanek Norma Gouvêa , De Oliveira Paulo Jansen 
Published: February 2019

The rheological behavior of the carboxymethylcellulose (CMC) / starch blends with and without zinc oxide (ZnO) have been investigated by controlled shear rate testing ramps. All blends showed high shear thinning flow behavior, (n=0,10 - 0,32) without ZnO and (n=0,10-0,29) with ZnO. The consistency index (K) and apparent viscosity (ηa,100 ) decreased with increasing amount of starch and with the addition of 1% wt ZnO. The results also showed that occurs an inversion in the elastic and viscous modulii behavior between 25 and 700C, obeying the Arrhenius equation. The study of activation energy showed that ZnO acts in the CMC phase, increase of viscosity of mixtures. The creep and recovery test indicated a decrease in the viscosity zero shear rate, indicating an increase of viscous character. The phase angle results also confirm an increase of viscosity with addition of ZnO.
Reflexões sobre a Educação Ambiental Crítica em um grupo de pesquisa: um estudo de caso do GEASUR.
Authors: Stortti Marcelo Aranda , Pereira Celso Sanchez 
Published: February 2019

Neste trabalho admoestamos refletir sobre as pesquisas e a práxis de educação ambiental realizadas no âmbito do Grupo de Estudos de Educação Ambiental Desde El Sur (GEASur) da Universidade Federal do Estado do Rio de Janeiro (UNIRIO). Neste sentido, buscamos conhecer e refletir a educação ambiental produzida nesse grupo de pesquisa na perspectiva do sul global, bem como, a contextualização necessária às complexas realidades dessa região. Para o GEASUR, esta abordagem pedagógica parte de premissas Freirianas e do campo dos estudos decoloniais críticos. A partir desse referencial teórico-metodológico, apresentamos estudos de casos sobre a educação ambiental e as pedagogias de resistência dos grupos em luta contra as petroleiras na Argentina e no Brasil, mais especificamente no caso da Baía da Guanabara (RJ). A partir das analises das pesquisas anteriores, observa-se que essa aproximação teórica pode trazer contribuições para a perspectiva da pesquisa e da práxi em educação ambiental crítica sobretudo ao reconhecer as educações ambientais e as práxis pedagógicas constitutivas dos movimentos sociais anteriores que vão além dos processos de educação popular corriqueiramente observados. Esses movimentos se reinventam e criam novas estratégias a todo instante, logo apresentam potencial criador e criativo que pode ajudar a refletir a educação ambiental de uma forma profundamente estruturante em todos os seus espaços e formas de atuação.
Avaliação da atividade antimicrobiana de metabólitos secundários de cianobactérias isoladas de ambientes hídricos
Authors: Zamprogna Camila Kunz , Werlang Chariane , Zeni Ternus Raquel 
Published: February 2019

Organismos aquáticos são reconhecido como potenciais reservatórios de produtos naturais biativos. Neste contexto, cianobactérias tem surgido como uma fonte promissora destes compostos. O objetivo deste trabalho foi estudar características biológicas e potencial biotecnológico de metabólitos secundários de cianobactérias isoladas em ambientes hídricos da região oeste catarinense. As amostras foram coletadas em ambientes naturais, em zona urbana e zona rural. Os cultivos foram feitos em meio BG-11 e os testes de atividade antimicrobiana realizados pelo de teste de capacidade antimicrobiana por disco difusão. O ensaio foi realizado em Placa com Ágar Mueller testando os isolados de cianobactérias frente a 5 micro-organismos (Bacillus cereus, Salmonella Typhimurium, Staphylococcus aureus, Escherichia coli, Candida albicans). Resultados de halos de inibição, variando de 7 a 14 mm foram obtidos para Staphylococcus aureus, indicando o potencial bioativo.