bluuebunny/crossref_metadata_2025_split huggingface dataset:
Atomic-scale engineering of indium oxide promotion by palladium for methanol production via CO2 hydrogenation
Authors: Frei Matthias S. , Mondelli Cecilia , García-Muelas Rodrigo , Kley Klara S. , Puértolas Begoña , López Núria , Safonova Olga V. , Stewart Joseph A. , Curulla Ferré Daniel , Pérez-Ramírez Javier 
Published: July 2019

AbstractMetal promotion is broadly applied to enhance the performance of heterogeneous catalysts to fulfill industrial requirements. Still, generating and quantifying the effect of the promoter speciation that exclusively introduces desired properties and ensures proximity to or accommodation within the active site and durability upon reaction is very challenging. Recently, In2O3was discovered as a highly selective and stable catalyst for green methanol production from CO2. Activity boosting by promotion with palladium, an efficient H2-splitter, was partially successful since palladium nanoparticles mediate the parasitic reverse water–gas shift reaction, reducing selectivity, and sinter or alloy with indium, limiting metal utilization and robustness. Here, we show that the precise palladium atoms architecture reached by controlled co-precipitation eliminates these limitations. Palladium atoms replacing indium atoms in the active In3O5ensemble attract additional palladium atoms deposited onto the surface forming low-nuclearity clusters, which foster H2activation and remain unaltered, enabling record productivities for 500 h.
Target specific functions of EPL interneurons in olfactory circuits
Authors: Liu Gary , Froudarakis Emmanouil , Patel Jay M. , Kochukov Mikhail Y. , Pekarek Brandon , Hunt Patrick J. , Patel Mayuri , Ung Kevin , Fu Chia-Hsuan , Jo Juyeong , Lee Hyun-Kyoung , Tolias Andreas S. , Arenkiel Benjamin R. 
Published: July 2019

AbstractInhibitory interneurons are integral to sensory processing, yet revealing their cell type-specific roles in sensory circuits remains an ongoing focus. To Investigate the mouse olfactory system, we selectively remove GABAergic transmission from a subset of olfactory bulb interneurons, EPL interneurons (EPL-INs), and assay odor responses from their downstream synaptic partners — tufted cells and mitral cells. Using a combination of in vivo electrophysiological and imaging analyses, we find that inactivating this single node of inhibition leads to differential effects in magnitude, reliability, tuning width, and temporal dynamics between the two principal neurons. Furthermore, tufted and not mitral cell responses to odor mixtures become more linearly predictable without EPL-IN inhibition. Our data suggest that olfactory bulb interneurons, through exerting distinct inhibitory functions onto their different synaptic partners, play a significant role in the processing of odor information.
Historical phenotypic data from seven decades of seed regeneration in a wheat ex situ collection
Authors: Philipp Norman , Weise Stephan , Oppermann Markus , Börner Andreas , Keilwagen Jens , Kilian Benjamin , Arend Daniel , Zhao Yusheng , Graner Andreas , Reif Jochen C. , Schulthess Albert W. 
Published: July 2019

AbstractGenebanks are valuable sources of genetic diversity, which can help to cope with future problems of global food security caused by a continuously growing population, stagnating yields and climate change. However, the scarcity of phenotypic and genotypic characterization of genebank accessions severely restricts their use in plant breeding. To warrant the seed integrity of individual accessions during periodical regeneration cycles in the field phenotypic characterizations are performed. This study provides non-orthogonal historical data of 12,754 spring and winter wheat accessions characterized for flowering time, plant height, and thousand grain weight during 70 years of seed regeneration at the German genebank. Supported by historical weather observations outliers were removed following a previously described quality assessment pipeline. In this way, ready-to-use processed phenotypic data across regeneration years were generated and further validated. We encourage international and national genebanks to increase their efforts to transform into bio-digital resource centers. A first important step could consist in unlocking their historical data treasures that allows an educated choice of accessions by scientists and breeders.
A triphenylethylene nonsteroidal SERM attenuates cervical cancer growth
Authors: Chauhan Neeraj , Maher Diane M. , Yallapu Murali M. , B. Hafeez Bilal , Singh Man M. , Chauhan Subhash C. , Jaggi Meena 
Published: July 2019

AbstractSelective estrogen receptor modulator drug molecules of triphenylethylene family have gained considerable attention as anti-cancer agents. Despite recent advances in screening and development of HPV vaccines, cervical cancer remains one of the deadliest malignancies as advanced stage metastatic disease is mostly untreatable, thus warrants newer therapeutic strategies. Ormeloxifene (ORM) is a well-known SERM of triphenylethylene family that has been approved for human use, thus represents an ideal molecule for repurposing. In this study, we for the first time have demonstrated the anti-cancerous properties of ormeloxifene in cervical cancer. Ormeloxifene efficiently attenuated tumorigenic and metastatic properties of cervical cancer cells via arresting cell cycle at G1-S transition, inducing apoptosis, decreasing PI3K and Akt phosphorylation, mitochondrial membrane potential, and modulating G1-S transition related proteins (p21, cyclin E and Cdk2). Moreover, ORM repressed the expression of HPV E6/ E7 oncoproteins and restored the expression of their downstream target tumor suppressor proteins (p53, Rb and PTPN 13). As a result, ormeloxifene induces radio-sensitization in cervical cancer cells and caused potent tumor growth inhibition in orthotopic mouse model. Taken together, ormeloxifene represents an alternative therapeutic modality for cervical cancer which may have rapid clinical translation as it is already proven safe for human use.
Lower Attentional Skills predict increased exploratory foraging patterns
Authors: Van den Driessche Charlotte , Chevrier Françoise , Cleeremans Axel , Sackur Jérôme 
Published: July 2019

AbstractWhen engaged in a search task, one needs to arbitrate between exploring and exploiting the environment to optimize the outcome. Many intrinsic, task and environmental factors are known to influence the exploration/exploitation balance. Here, in a non clinical population, we show that the level of inattention (assessed as a trait) is one such factor: children with higher scores on an ADHD (Attention Deficit/Hyperactivity Disorder) questionnaire exhibited longer transitions between consecutively retrieved items, in both a visual and a semantic search task. These more frequent exploration behaviours were associated with differential performance patterns: children with higher levels of ADHD traits performed better in semantic search, while their performance was unaffected in visual search. Our results contribute to the growing literature suggesting that ADHD should not be simply conceived as a pure deficit of attention, but also as a specific cognitive strategy that may prove beneficial in some contexts.
An experimental study of a virtual reality counselling paradigm using embodied self-dialogue
Authors: Slater Mel , Neyret Solène , Johnston Tania , Iruretagoyena Guillermo , Crespo Mercè Álvarez de la Campa , Alabèrnia-Segura Miquel , Spanlang Bernhard , Feixas Guillem 
Published: July 2019

AbstractWhen faced with a personal problem people typically give better advice to others than to themselves. A previous study showed how it is possible to enact internal dialogue in virtual reality (VR) through participants alternately occupying two different virtual bodies – one representing themselves and the other Sigmund Freud. They could maintain a self-conversation by explaining their problem to the virtual Freud and then from the embodied perspective of Freud see and hear the explanation by their virtual doppelganger, and then give some advice. Alternating between the two bodies they could maintain a self-dialogue, as if between two different people. Here we show that the process of alternating between their own and the Freud body is important for successful psychological outcomes. An experiment was carried out with 58 people, 29 in the body swapping Self-Conversation condition and 29 in a condition where they only spoke to a Scripted Freud character. The results showed that the Self-Conversation method results in a greater perception of change and help compared to the Scripted. We compare this method with the distancing paradigm where participants imagine resolving a problem from a first or third person perspective. We consider the method as a possible strategy for self-counselling.
Bubble formation and scale dependence in free-surface air entrainment
Authors: Wei Wangru , Xu Weilin , Deng Jun , Tian Zhong , Zhang Faxing 
Published: July 2019

AbstractThe air bubble entrainment and self–aeration phenomena in free-surface water flows reveal a rich interplay of fundamental science and engineering, and the size distribution of the entrained bubbles enhances the air–water gas flux, improves the gas transfer, and influences the cavitation erosion protection in high–speed flows. In the present study, we investigate the bubble–formation mechanism of free–surface air entrainment and the related microscopic bubble scale in the laboratory. This paper provides a quantitative description of bubble entrainment. The entrapment deformation of the local free surface over a period follows a power–law scaling and entrains a bubble when the entrapped surface becomes enclosed in the unstable movement period. Both the size scale and shape character of the entrapped free surface determine the size and skewness of the distribution of the air bubble. The entrapment deformation process confirms that the instability behaviour of the local air–water interface results in the onset of bubble entrainment. Further research is necessary to elucidate the instability criterion dominated by the interface instability and promote a new understanding of multiphase flow generation and development.
Prevalence, Awareness, Treatment, and Control of Hypertension in Korea
Authors: Kang Si-Hyuck , Kim Sun-Hwa , Cho Jun Hwan , Yoon Chang-Hwan , Hwang Seung-Sik , Lee Hae-Young , Youn Tae-Jin , Chae In-Ho , Kim Cheol-Ho 
Published: July 2019

AbstractThe purpose of the present study was to describe the temporal trends in prevalence and management status of hypertension in Korea between 1998 and 2015. Data of adults who were aged 30 years or older were extracted from the Korea National Health and Nutrition Examination Survey, a nationwide representative population-based survey. Hypertension was prevalent in 30.5% of Korean adults. The age and sex standardized prevalence showed little change between 1998 and 2015. The elderly population and men showed higher prevalence. The rates of awareness, treatment, and control showed substantial improvements among hypertensive subjects between 1998 and the time period of 2007‒2009 (awareness, from 23.5 to 66.3%; treatment, from 20.4 to 60.3%; and control, from 4.9 to 42.1%), after which the numbers reached a plateau and no significant changes were observed subsequently (67.3%, 63.6%, and 46.2%, respectively, between 2013 and 2015). The management status remained poor especially among the young population and in men. In conclusion, the hypertension prevalence remained stable at approximately 30% in Korea between 1998 and 2015. While awareness, treatment, and control of hypertension improved remarkably, the young population and particularly men showed a suboptimal management status.
Mesoporous graphene adsorbents for the removal of toluene and xylene at various concentrations and its reusability
Authors: Lim Sun Taek , Kim Ji Hoon , Lee Chang Yeon , Koo Sangmo , Jerng Dong-Wook , Wongwises Somchai , Ahn Ho Seon 
Published: July 2019

AbstractAs novel technologies have been developed, emissions of gases of volatile organic compounds (VOCs) have increased. These affect human health and are destructive to the environment, contributing to global warming. Hence, regulations on the use of volatile organic compounds have been strengthened. Therefore, powerful adsorbents are required for volatile organic compounds gases. In this study, we used graphene powder with a mesoporous structure to adsorb aromatic compounds such as toluene and xylene at various concentrations (30, 50, 100 ppm). The configuration and chemical composition of the adsorbents were characterized using scanning electron microscopy (SEM), N2 adsorption-desorption isotherm measurements, and X-ray photoelectron spectroscopy (XPS). The adsorption test was carried out using a polypropylene filter, which contained the adsorbents (0.25 g), with analysis performed using a gas detector. Compared to graphite oxide (GO) powder, the specific surface area of thermally expanded graphene powder (TEGP800) increased significantly, to 542 m2 g−1, and its chemical properties transformed from polar to non-polar. Thermally expanded graphene powder exhibits high adsorption efficiency for toluene (92.7–98.3%) and xylene (96.7–98%) and its reusability is remarkable, being at least 91%.
Double-deep Q-learning to increase the efficiency of metasurface holograms
Authors: Sajedian Iman , Lee Heon , Rho Junsuk 
Published: July 2019

AbstractWe use a double deep Q-learning network (DDQN) to find the right material type and the optimal geometrical design for metasurface holograms to reach high efficiency. The DDQN acts like an intelligent sweep and could identify the optimal results in ~5.7 billion states after only 2169 steps. The optimal results were found between 23 different material types and various geometrical properties for a three-layer structure. The computed transmission efficiency was 32% for high-quality metasurface holograms; this is two times bigger than the previously reported results under the same conditions. The found structure is transmission-type and polarization-independent and works in the visible region.
Host circadian rhythms are disrupted during malaria infection in parasite genotype-specific manners
Authors: Prior Kimberley F. , O’Donnell Aidan J. , Rund Samuel S. C. , Savill Nicholas J. , van der Veen Daan R. , Reece Sarah E. 
Published: July 2019

AbstractInfection can dramatically alter behavioural and physiological traits as hosts become sick and subsequently return to health. Such “sickness behaviours” include disrupted circadian rhythms in both locomotor activity and body temperature. Host sickness behaviours vary in pathogen species-specific manners but the influence of pathogen intraspecific variation is rarely studied. We examine how infection with the murine malaria parasite, Plasmodium chabaudi, shapes sickness in terms of parasite genotype-specific effects on host circadian rhythms. We reveal that circadian rhythms in host locomotor activity patterns and body temperature become differentially disrupted and in parasite genotype-specific manners. Locomotor activity and body temperature in combination provide more sensitive measures of health than commonly used virulence metrics for malaria (e.g. anaemia). Moreover, patterns of host disruption cannot be explained simply by variation in replication rate across parasite genotypes or the severity of anaemia each parasite genotype causes. It is well known that disruption to circadian rhythms is associated with non-infectious diseases, including cancer, type 2 diabetes, and obesity. Our results reveal that disruption of host circadian rhythms is a genetically variable virulence trait of pathogens with implications for host health and disease tolerance.
Alpha-synuclein is a DNA binding protein that modulates DNA repair with implications for Lewy body disorders
Authors: Schaser Allison J. , Osterberg Valerie R. , Dent Sydney E. , Stackhouse Teresa L. , Wakeham Colin M. , Boutros Sydney W. , Weston Leah J. , Owen Nichole , Weissman Tamily A. , Luna Esteban , Raber Jacob , Luk Kelvin C. , McCullough Amanda K. , Woltjer Randall L. , Unni Vivek K. 
Published: July 2019

AbstractAlpha-synuclein is a presynaptic protein that forms abnormal cytoplasmic aggregates in Lewy body disorders. Although nuclear alpha-synuclein localization has been described, its function in the nucleus is not well understood. We demonstrate that alpha-synuclein modulates DNA repair. First, alpha-synuclein colocalizes with DNA damage response components within discrete foci in human cells and mouse brain. Removal of alpha-synuclein in human cells leads to increased DNA double-strand break (DSB) levels after bleomycin treatment and a reduced ability to repair these DSBs. Similarly, alpha-synuclein knock-out mice show increased neuronal DSBs that can be rescued by transgenic reintroduction of human alpha-synuclein. Alpha-synuclein binds double-stranded DNA and helps to facilitate the non-homologous end-joining reaction. Using a new, in vivo imaging approach that we developed, we find that serine-129-phosphorylated alpha-synuclein is rapidly recruited to DNA damage sites in living mouse cortex. We find that Lewy inclusion-containing neurons in both mouse model and human-derived patient tissue demonstrate increased DSB levels. Based on these data, we propose a model whereby cytoplasmic aggregation of alpha-synuclein reduces its nuclear levels, increases DSBs, and may contribute to programmed cell death via nuclear loss-of-function. This model could inform development of new treatments for Lewy body disorders by targeting alpha-synuclein-mediated DNA repair mechanisms.
Factors influencing clinical outcomes in patients with diabetic macular edema treated with intravitreal ranibizumab: comparison between responder and non-responder cases
Authors: Chen Yen-Po , Wu Ai-Ling , Chuang Chih-Chun , Chen San-Ni 
Published: July 2019

AbstractDiabetic macular edema (DME) is the leading cause of visual impairment in patients with diabetes mellitus. A retrospective study was conducted to investigate the factors influencing the clinical outcomes in 73 patients (94 eyes) with DME treated with intravitreal ranibizumab therapy. Baseline demographic, systemic, and ocular data were assessed for the association with visual and anatomic outcomes after treatment. The mean best corrected visual acuity (BCVA) improved from 0.92 ± 0.45 to 0.61 ± 0.43 logarithm of the minimum angle of resolution (LogMAR) (p < 0.001) after treatment. The mean central subfield macular thickness (CST) decreased from 425.2 ± 127.4 to 328.6 ± 99.4 μm (p < 0.001). The treatment response was significantly influenced by Age (p = 0.003) and baseline BCVA (p = 0.001). In addition, glycosylated hemoglobin (HbA1c) (p = 0.013) and proliferative diabetic retinopathy (PDR) (p = 0.019) were the prognostic factors for the visual outcome in the responders and non-responders, respectively. Moreover, baseline CST was the strongest predictor of anatomic outcome in all subjects (p < 0.001). Intravitreal ranibizumab for DME resulted in significant improvement in clinical outcomes. Younger age and better baseline BCVA were associated with better visual outcome after the treatment. In addition, glycemic control in the treatment of patients with DME is crucial to achieve better visual outcomes, especially in the responders to ranibizumab treatment.
Short amylin receptor antagonist peptides improve memory deficits in Alzheimer’s disease mouse model
Authors: Soudy Rania , Kimura Ryoichi , Patel Aarti , Fu Wen , Kaur Kamaljit , Westaway David , Yang Jing , Jhamandas Jack 
Published: July 2019

AbstractRecent evidence supports involvement of amylin and the amylin receptor in the pathogenesis of Alzheimer’s disease (AD). We have previously shown that amylin receptor antagonist, AC253, improves spatial memory in AD mouse models. Herein, we generated and screened a peptide library and identified two short sequence amylin peptides (12–14 aa) that are proteolytically stable, brain penetrant when administered intraperitoneally, neuroprotective against Aβ toxicity and restore diminished levels of hippocampal long term potentiation in AD mice. Systemic administration of the peptides for five weeks in aged 5XFAD mice improved spatial memory, reduced amyloid plaque burden, and neuroinflammation. The common residue SQELHRLQTY within the peptides is an essential sequence for preservation of the beneficial effects of the fragments that we report here and constitutes a new pharmacological target. These findings suggest that the amylin receptor antagonism may represent a novel therapy for AD.
Roles of matricellular CCN2 deposited by osteocytes in osteoclastogenesis and osteoblast differentiation
Authors: Nishida Takashi , Kubota Satoshi , Yokoi Hideki , Mukoyama Masashi , Takigawa Masaharu 
Published: July 2019

AbstractIn this study, we investigated the effect of CCN2 (cellular communication network factor 2), previously termed connective tissue growth factor, deposited in bone matrix on osteoclastogenesis and osteoblast differentiation. To mimic the bone matrix environment, osteocytic MLO-Y4 cells had been embedded in collagen-gel with recombinant CCN2 (rCCN2), and mouse macrophage-like RAW264.7 cells were inoculated on the gel and treated with receptor activator of NF-κB ligand (RANKL). NFATc1 and cathepsin K (CTSK) productions were more increased in the combination of RAW264.7 and MLO-Y4 cells treated with rCCN2 than the combination without rCCN2. Next, we isolated an osteocyte-enriched population of cells and osteoclast progenitor cells from wild type and tamoxifen-inducible Ccn2-deficient (KO) mice and performed similar analysis. NFATc1 and CTSK productions were decreased in the KO osteocyte-enriched population at 6 months after the tamoxifen injection, regardless of the origin of the osteoclast progenitor cells. Interestingly, CTSK production was rather increased in KO osteocytes at 1 year after the injection. Finally, the combination of osteoblastic MC3T3-E1 and MLO-Y4 cells in rCCN2-containing bone matrix revealed the up-regulation of osteoblastic marker genes. These findings suggest that CCN2 supplied by osteocytes regulates both osteoclastogenesis and osteoblast differentiation.
Three decades of heat stress exposure in Caribbean coral reefs: a new regional delineation to enhance conservation
Authors: Muñiz-Castillo Aarón Israel , Rivera-Sosa Andrea , Chollett Iliana , Eakin C. Mark , Andrade-Gómez Luisa , McField Melanie , Arias-González Jesús Ernesto 
Published: July 2019

AbstractIncreasing heat stress due to global climate change is causing coral reef decline, and the Caribbean has been one of the most vulnerable regions. Here, we assessed three decades (1985–2017) of heat stress exposure in the wider Caribbean at ecoregional and local scales using remote sensing. We found a high spatial and temporal variability of heat stress, emphasizing an observed increase in heat exposure over time in most ecoregions, especially from 2003 identified as a temporal change point in heat stress. A spatiotemporal analysis classified the Caribbean into eight heat-stress regions offering a new regionalization scheme based on historical heat exposure patterns. The temporal analysis confirmed the years 1998, 2005, 2010–2011, 2015 and 2017 as severe and widespread Caribbean heat-stress events and recognized a change point in 2002–2004, after which heat exposure has been frequent in most subsequent years. Major heat-stress events may be associated with El Niño Southern Oscillation (ENSO), but we highlight the relevance of the long-term increase in heat exposure in most ecoregions and in all ENSO phases. This work produced a new baseline and regionalization of heat stress in the basin that will enhance conservation and planning efforts underway.