bluuebunny/crossref_metadata_2025_split huggingface dataset:
Coexistence of hemoglobin Handsworth and alpha 3.7 kb deletion in Caucasian woman in Poland
Authors: Klimczak-Jajor Edyta , Skulimowska Joanna , Ejduk Anna , Guz Katarzyna , Uhrynowska Małgorzata , Brojer Ewa 
Published: May 2019

AbstractBackgroundThis report presents a case of an adult Polish women of Caucasian origin who was heterozygous for the nondeletional mutation: Hb Handsworth (HBA2 or HBA1: c.55G > C, p.Gly19Arg) and deletional (-α3.7) α-thalassemia mutation.MethodsThe HbA2 and HbF levels were measured by microcolumn chromatography and alkaline denaturation procedure, respectively, while electrophoresis was used to detect pathological hemoglobin fraction. The β- and α-globin genotypes were determined by DNA sequencing, gap-polymerase chain reaction, α gene triplication and MLPA.ResultsThe HbA2 and HbF levels were normal, but hemoglobin electrophoresis on agarose gel alkaline pH showed a strong band migration in a position of hemoglobin S and faint bands in the neighborhood of band A on acid electrophoresis. Molecular analysis of the alpha globin cluster detected a point mutation at codon 19 in HBA2 (c.55G > C, p.Gl- y19Arg) and deletion -α3.7.ConclusionsOur compound heterozygosity does not produce severe clinical or hematological symptoms but it is important to say that in our part of Europe such cases do appear. Molecular analysis of the alpha globin cluster is required for correct diagnosis in patients with normal HbA2 levels. Compound heterozygosity was unmasked by molecular diagnosis only.
Stem Cell Transplantation in Pediatric Patients with Myelodysplastic Syndrome at a Single Institution
Authors: Al-Sweedan Suleimman , Alassiri Mona , Aljamal Ghaida , Jafri Rafat , Alseraihy Amal , Siddiqui Khawar 
Published: May 2019

AbstractIn MDS, the bone marrow produces abnormal, immature blood cells called blast cells. Imprecise, in half of pediatric MDS, blast count is normal. A retrospective observational study was conducted to review the outcome of our HCT in pediatric patients with MDS. Record of 35 MDS patients after BMT, 1993-2016, were reviewed. Median age at transplant was 4 yrs (0.8-14.8) and median time to transplant from diagnosis 8.1 (2.3-102.5) months. TRM was 17.1% (6); [low risk (LR) = 5 (19.2%) and high risk (HR) = 1 (11.1%)] MDS group succumbed within first 100 days. The rest were fully engrafted; [low risk = 21 (72.4%) and high risk = 8 (27.6%)]. Primary and secondary graft failure was observed in one patient each (2.9%). VOD was seen in 2 patients (5.7%) and 5 (14.3%) had hemorrhagic cystitis. With a median follow-up of 112.4 months and 12 events of mortality, 3-years OS was 68.1% ± 8.0%. No significant risk factor including age, time to transplant, disease risk group, gender, conditioning regimen, source of stem cells, or a GvHD through uni- or multi-variable analyses were found to be associated with OS. Bu/Cy/±ATG conditioning regimen showed a trend of superiority for OS and EFS in our small series. The relapse incidence in our cohort was 11.5% in LR MDS.
Abnormal hemostasis screening tests leading to diagnosis of multiple myeloma
Authors: Iwaniec Teresa , Zdziarska Joanna , Jurczyszyn Artur 
Published: May 2019

AbstractMultiple myeloma (MM) is a rare malignancy, characterized by clonal proliferation of plasma cells, secreting monoclonal immunoglobulin. It is usually diagnosed based on histopathologic and immunophenotypic bone marrow examination. Abnormal results of screening coagulation tests, including prothrombin time, activated partial thromboplastin time and thrombin time, are commonly encountered in patients with plasma cell neoplasms. They do not, however, reflect bleeding tendency. We describe a 71-year-old patient who was accidentally diagnosed with multiple myeloma during coagulation diagnostics.
Impact of perioperative treatment on survival of resectable gastric cancer patients after D2 lymphadenectomy: a single European centre propensity score matching analysis
Authors: Jagric Tomaz , Ilijevec Bojan , Velenik Vaneja , Ocvirk Janja , Potrc Stojan 
Published: May 2019

Abstract

Background
To determine the effects of perioperative treatment of gastric cancer patients, we conducted an analysis with propensity score matched patient groups to determine the role of perioperative chemotherapy in patients after D2 lymphadenectomy.

Patients and methods
From our database of 1563 patients, 482 patients were selected with propensity score matching and divided into two balanced groups: 241 patients in the surgery only group and 241 patients in the perioperative group. The long-term results of treatment were compared between the two groups.

Results
Most of the included patients received radio-chemotherapy with capecitabine (n = 111; 46%) and perioperative chemotherapy with epirubicin, oxalliplatin and capecitabine (n = 91; 37.7%). 92.9% of the patients received a D2 lymph node dissection. Perioperative morbidity was similar between surgery only (18.3%) and perioperative treatment groups (20.7%) (p = 0.537). The perioperative mortality was not influenced by perioperative treatment. A pathological response was observed in 12.5% of patients. The overall 5-year and median survivals were significantly higher in the perioperative treatment group (50.5%; 51.7 moths) compared to surgery only group (41.8%; 34.9 months; p = 0.038). The subgroup analysis revealed that only patients with the TNM stages T3 (p = 0.028), N2 (p = 0.009), N3b (p = 0.043), and UICC stages IIIb (p = 0.003) and IIIc (p = 0.03) significantly benefit from perioperative treatment.

Conclusions
Perioperative treatment in radically resected gastric cancer patients after D2 lymphadenectomy was beneficial in stages IIIb and IIIc. The effects of perioperative treatment in lower stages could be negated by the effects of the radical surgery in lower stages and in higher stages by the biology of the disease.
Multiparametric MRI - local staging of prostate cancer and beyond
Authors: Caglic Iztok , Kovac Viljem , Barrett Tristan 
Published: May 2019

Abstract

Background
Accurate local staging is critical for treatment planning and prognosis in patients with prostate cancer (PCa). The primary aim is to differentiate between organ-confined and locally advanced disease with the latter carrying a worse clinical prognosis. Multiparametric MRI (mpMRI) is the imaging modality of choice for the local staging of PCa and has an incremental value in assessing pelvic nodal disease and bone involvement. It has shown superior performance compared to traditional staging based on clinical nomograms, and provides additional information on the site and extent of disease. MRI has a high specificity for diagnosing extracapsular extension (ECE), seminal vesicle invasion (SVI) and lymph node (LN) metastases, however, sensitivity remains poor. As a result, extended pelvic LN dissection remains the gold standard for assessing pelvic nodal involvement, and there has been recent progress in developing advanced imaging techniques for more distal staging.

Conclusions
T2W-weighted imaging is the cornerstone for local staging of PCa. Imaging at 3T and incorporating both diffusion weighted and dynamic contrast enhanced imaging can further increase accuracy. “Next generation” imaging including whole body MRI and PET-MRI imaging using prostate specific membrane antigen (68Ga-PSMA), has shown promising for assessment of LN and bone involvement as compared to the traditional work-up using bone scintigraphy and body CT.
Long term survival in 200 patients with advanced stage of colorectal carcinoma and diabetes mellitus – a single institution experience
Authors: Besic Nikola , Povsic Milena Kerin 
Published: May 2019

Abstract

Background
Diabetes mellitus (DM) and DM related comorbidities may initiate difficulties during cancer specific treatment and may have an impact on cancer management and outcome. The aim of our study was to find out if DM in patients with advanced colorectal carcinoma (CRC) is associated with cancer-specific or overall survival.

Patients and methods
This study included 200 consecutive patients (131 males, 69 females, mean age 63 years) with elective CRC surgery at the Institute of Oncology Ljubljana and DM was found in 39 (19.5%) of them. Even 64% of patients had Stage 3 or 4 disease, so neo-adjuvant chemotherapy (CTX) and/or radiotherapy (RT) were carried out in 59% of cases. Data about gender, age, body mass index, presence of DM, American Society of Anesthesiologists (ASA) physical status score, stage of disease and postoperative complications were collected prospectively. Cancer-specific survival and overall survival were compared by log-rank test.

Results
Patients with DM had a higher ASA score, BMI, the illness marker, rate of massive bleeding, blood transfusion and longer hospital stay than those without DM. The mean follow-up period was 4.75 years. All causes mortality in patients with DM and without DM was 23% and 27%, respectively. Three-year cancer-specific survival in patients with DM and without DM was 85% and 89%, respectively (p = 0.68). Three-year overall survival in patients with DM and without DM was 82% and 84%, respectively (p = 0.63).

Conclusions
The presence of DM was not associated with tumor stage, disease-specific survival or overall survival in patients with advanced CRC.
Evaluation of MRI accuracy after primary systemic therapy in breast cancer patients considering tumor biology: optimizing the surgical planning
Authors: Bouzón Alberto , Iglesias Ángela , Acea Benigno , Mosquera Cristina , Santiago Paz , Mosquera Joaquín 
Published: May 2019

Abstract

Background
We analyzed the accuracy of magnetic resonance imaging (MRI) after primary systemic therapy (PST) according to tumor subtype.

Patients and methods
Two-hundred and four breast cancer patients treated with PST were studied. MRI findings after PST were compared with pathologic findings, and results were stratified based on tumor subtype.

Results
Of the two-hundred and four breast cancer patients, eighty-four (41.2%) achieved a pathologic complete response (pCR) in the breast. The MRI accuracy for predicting pCR was highest in triple-negative (TN) and HER2-positive (non-luminal) breast cancer (83.9 and 80.9%, respectively). The mean size discrepancy between MRI-measured and pathologic residual tumor size was lowest in TN breast cancer and highest in luminal B-like (HER2-negative) breast cancer (0.45cm vs. 0.98 cm, respectively; p = 0.003). After breast conserving surgery (BCS), we found a lower rate of positive margins in TN breast cancer and a higher rate of positive margins in luminal B-like (HER2-negative) breast cancer (2.4% vs. 23.6%, respectively).

Conclusions
If tumor response after PST is assessed by MRI, tumor subtype should be considered when BCS is planned. The accuracy of MRI is highest in TN breast cancer.
The Schorsing in Implementation of Administrative Decision that Endanger the Environment by Administrative Court
Authors: Caniago Miftah Sa'ad 
Published: May 2019

The postponement criteria of the implementation of KTUN (Administrative Court Decision) based on Article 67 of the Act Number 5, 1986 concerning the State Administrative Court (the Act of Administrative Court) merely states that such Postponement can be made if there is a very urgent circumstance which results in the plaintiff's interest to be lost if the sued state’s administrative decision is still implemented. By the promulgation of the Act Number 30, 2014 on the Governance Administration, it reregulates the delay of the implementation of the decision worded in Article 65. However, there are varies in the regulation of the implementation of the such decision pursuant to Article 67, of the Act Law Number 5, 1986 concerning the State Administrative Court. In accordance with Article 65 of the Administrative Governance Act, it rules more detailed regarding the reasons for the State Administrative Court that may delay the enforcement of a Government Decree, one of which if a Government Decision or Action "has the potential to cause environmental damage" and the Court in issuing such a delay shall be in the form of a "Verdict", so that it is different from the arrangement in Article 67 of the State Administrative Judicature Law and its derivatives which stipulates that the reason for the postponement of the validity of a State Administrative Decree if there is an "urgent circumstance" issued in the form of "Stipulation".
The research shows that the Act Number 30, 2014 as a substantive law does not regulate in detailed regarding procedural law of such adjournment application, hence based on the principle of lex specialis derogat legi generali a judge has to refer to the rule on the postponement that already exist till it is enacted the new one that might accommodate the postponement implementation and it can determine that the Postponement Execution Delay a judge must view the urgency of the Decision/the Government Action might be delayed by referring to review result or auditing from auditors of the environment that has been certified by the LSK of environmental auditors that is under the Ministry of Environment, and it is not against “ the public interest”.
The Effectiveness Of Qanun Aceh No. 6/2014 Of Jinayat Law In Order To Prevent Jinayah Khalwat In Law Territory Of Sabang Municipality
Authors: Aditya Webby 
Published: May 2019

Article 23 paragraph (1) of Aceh Islamic Criminal Law No 6 of 2014 tells about Indecency (Jinayat) law which regulates the criminal punishment for the perpetrator of jarimah khalwat. This article is expected can minimize the crime rate of the indecent (jinayah) behavior perpetrator. However, in fact the number of jarimah khalwat perpetrator increase steadily as what happened in Sabang Municipality law area. It proves that there were two legal issues, what is the causes of the ineffectiveness of the indecency (jinayat) law in minimizing the number of jinayat perpetrator in Sabang Municipality? This research was aimed to know the obstacle of the increasing jinayat khalwat issue which make jinayat law become ineffective in minimizing jinayat khalwat perpetrators in Sabang Municipality, and to know the efforts conducted by the Civil Service Police Unit, Sharia Policy, and Office of the District Prosecutor General of Sabang Municipality and to know the factor which causes the number of jinayah khalwat perpetrator in Sabang Municipality. The research method used in this research was empirical juridical empirical using case approach, historical approach, comparative approach, conceptual approach, and statute approach). The research result shown that there were 3 effectiveness obstacle factors of jinayat law in Sabang Municipality, the first obstacle of jinayat law is the bad regulation because the punishment is an alternative not a cumulative and for those who deal with the jinayat law is potentially punished with canning punishment in public, the application of jinayat law normatively is in contrary with the basis of personality and territoriality which causes this law contrary with the fair legal system (due process of law). The second factor which becomes the obstacle related to quality and quantity of the human resource of the law enforcement, law understanding and the number of personnel investigator of the Civil Service Police Unit and Sharia Police of Sabang Municipality was limited. The third factor, there is no special jinayah prison cell in the Civil Service Police Unit and Sharia Police of Sabang Municiplaity
Die Rooms-Katolieke Wortels van die Mistiek in die Sewentiende en Agttiende-Eeuse Kaapse PiÃ«tisme
Authors: Raath Andries W.G. 
Published: May 2019

The research on Cape spirituality of the eighteenth and nineteenth century by Christina Landman, Celestina Pretorius and Karel Schoeman shifted the focus from a constructivist to a transconfessional religious profile. The research of Landman and Schoeman heralded a new era in Pietism research in South African religious and historiographical publications: both authors point out the manifold religious origins of Pietism at the Cape, the mystical nature of Cape Pietism and suggest Medieval origins of the mysticism at the heart of Cape pietistic spirituality. This essay traces the mystical roots of Cape Pietism to prominent Roman Catholic authors: Bernard of Clairvaux, Thomas Ã Kempis and Johann Tauler. It is concluded that the mystical roots of Cape Protestant spirituality are not the exclusive inheritance of Roman Catholic spirituality but also of Protestant spirituality in Dutch and German Pietism
From South Africa to Different Corners of the Globe: Christian Formation as â€œPilgrimageâ€
Authors: Lesage Mark , Padilla Estela 
Published: May 2019

This is the story of how Anselm Prior, OFM, inspired a priest and a lay team from the Parish of St Joseph in Las PiÃ±as, Philippines, who attended the Lumko international course in Lesotho, South Africa in 1992. Concurrently within this narrative lies the birth of Anselm Priorâ€™s doctoral dissertation, for Prior â€œdiscoveredâ€ his thesis while working in the Bamboo Parish in Manila, taking the parish as the subject of his theological study. This parish team later established a pastoral centreâ€”Bukal ng Tipanâ€”serving the dioceses of the Philippines, and more widely dioceses in Asia and Europe. Inspired by the travelling, the authors explore the image of pilgrimage in discussing inculturation or contextualised Christian formation. The narrative informs the reader of the international reach of the Lumko Pastoral Institute under Anselm Prior, and how the Lumko template has influenced pastoral renewal throughout the Philippines and much of Asia. It is also a case study of how the turn to systematic reflection on experience during the last half century has decided the direction of theological undertakings in Asia and beyond.The first part of the article is written by Mark Lesage then parish priest of St Joseph Las PiÃ±as, sharing the beginnings of a mission journey with Anselm Prior of Lumko and the parish. The second part is written by Dr Estela PadillaÂ sharing how the inspiration of contextualised Christian formation from Â Lumko was further developed by Bukal ng Tipan and then shared with Asia and Europe.
Church Involvement in the Trans-Atlantic Slave Trade: Its Biblical Antecedent vis-Ã -vis the Societyâ€™s Attitude to Wealth
Authors: Antwi Emmanuel Kojo Ennin 
Published: May 2019

Slavery existed in most ancient cultures and continues to exist indirectly in some societies in its various forms. Though slavery was used openly in the past by ancient cultures to create wealth, it is today regarded as an act of injustice against humanity. The trans-Atlantic slave trade between the fifteenth and nineteenth century is no exception. Christians who claimed to have the love of God and humanity at the centre of their religion were involved in such atrocious trade practices to create wealth. The churchâ€™s involvement in this economic venture seems paradoxical and contrary to its mission of love for all humanity. This paper assesses the churchâ€™s involvement in the trans-Atlantic slave trade to unravel the motives of such a paradox. It traces the biblical antecedent to the slave trade vis-Ã -vis the societyâ€™s attitude to wealth. It explores how the Judaeo-Christian scriptures and the Greco-Roman world shaped the churchâ€™s understanding of slavery to see how the church perceived its practice and the motives for its involvement.
Mission and State Health Institutions: “Invisible” Public-Private Partnerships in Zimbabwe, 1980–1999
Authors: Mhike Ivo , Makombe Eric K 
Published: May 2019

This article argues that Zimbabwe’s independence in 1980 marked not the end of the missionary era, but its high point. Government’s poor rural health infrastructure forced it to partner missionary health institutions in order to run preventive health programmes and improve access to health services for the majority of the population. Mission health institutions formed the mainstay of rural African health care needs in the colonial period and continued to do so in the post-colonial period; with 97 clinics and 70 hospitals, and 13 of the country’s 42 designated district hospitals compared to 1 032—largely small and urban based—government, council and private health facilities. Mission health institutions were regulated by the Ministry of Health and were partly funded by the government. However, the significance of the mission health endeavour was overshadowed by an overarching government development agenda and narrative. This study establishes the nature and forms of public-private health partnerships in the development of Zimbabwe’s public health system and highlights the importance of the church’s healing mandate. It also refracts on church-state relations and the broader development and policy issues during the 1980s and 1990s.
A LITERATURA ALEMÃ DE WOLFGANG MENZEL, RESENHADA POR HEINRICH HEINE:
Authors: Silva Felipe Vale da 
Published: May 2019

Die deutsche Literatur von Wolfgang Menzel (1828) não é apenas uma das resenhas mais conhecidas de Heinrich Heine, mas também um importante documento sobre a cultura alemã em sua fase de transição do romantismo para a literatura da Jovem Alemanha (Junges Deutschland). O presente artigo, além de trazer a tradução integral do texto em questão, faz uma leitura que visa a evidenciar as principais tensões vividas por escritores naquele momento de assumida estagnação cultural e censura política. Heine se vale do registro da resenha para propor um programa estético inovador, e o faz declarando o final do Período da Arte (Kunstperiode) representado por Johann Wolfgang von Goethe e os teóricos do romantismo.