bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Chest Australia Trial: a randomised controlled trial of an intervention to increase consultation rates in smokers at risk of lung cancer
Authors: Emery Jon D , Murray Sonya R , Walter Fiona M , Martin Andrew , Goodall Stephen , Mazza Danielle , Habgood Emily , Kutzer Yvonne , Barnes David John , Murchie Peter 
Published: January 2019

BackgroundInternational research has focused on screening and mass media campaigns to promote earlier patient presentation and detect lung cancer earlier. This trial tested the effect of a behavioural intervention in people at increased risk of lung cancer on help-seeking for respiratory symptoms.MethodsParallel, individually randomised controlled trial. Eligible participants were long-term smokers with at least 20 pack-years, aged 55 and above. The CHEST intervention entailed a consultation to discuss and implement a self-help manual, followed by self-monitoring reminders to encourage help-seeking for respiratory symptoms. The control group received a brief discussion about lung health. Both groups had baseline spirometry. Telephone randomisation was conducted, 1:1, stratified Medical Research Council (MRC) dyspnoea score and general practice. Participants could not be blinded; data extraction and statistical analyses were performed blinded to group assignment. The primary outcome was respiratory consultation rates.ResultsWe randomised 551 participants (274 intervention, 277 control) from whom the primary outcome was determined for 542 (269 intervention, 273 control). There was a 40% relative increase in respiratory consultations in the intervention group: (adjusted rates (95% CI) intervention 0.57 (0.47 to 0.70), control 0.41 (0.32 to 0.52), relative rate 1.40 (1.08 to 1.82); p=0.0123). There were no significant differences in time to first respiratory consultation, total consultation rates or measures of psychological harm. The incremental cost-effectiveness ratio was $A1289 per additional respiratory consultation.ConclusionsA behavioural intervention can significantly increase consulting for respiratory symptoms in patients at increased risk of lung cancer. This intervention could have an important role in primary care as part of a broader approach to improve respiratory health in patients at higher risk.Trial registration numberAustralian New Zealand Clinical Trial Registry (1261300039 3752). This was registered pre-results.
Writeback-Aware LLC Management for PCM-Based Main Memory Systems
Authors: Pourshirazi Bahareh , Beigi Majed Valad , Zhu Zhichun , Memik Gokhan 
Published: January 2019

With the increase in the number of data-intensive applications on today's workloads, DRAM-based main memories are struggling to satisfy the growing data demand capacity. Phase Change Memory (PCM) is a type of non-volatile memory technology that has been explored as a promising alternative for DRAM-based main memories due to its better scalability and lower leakage energy. Despite its many advantages, PCM also has shortcomings such as long write latency, high write energy consumption, and limited write endurance, which are all related to the write operations.
In this article, we propose a novel writeback-aware Last Level Cache (LLC) management scheme named WALL to reduce the number of LLC writebacks and consequently improve performance, energy efficiency, and lifetime of a PCM-based main memory system. First, we investigate the writeback behavior of LLC sets and show that writebacks are not uniformly distributed among sets; some sets observe much higher writeback rates than others. We then propose a writeback-aware set-balancing mechanism, which employs the underutilized LLC sets with few writebacks as an auxiliary storage for the evicted dirty lines from sets with frequent writebacks. We also propose a simple and effective writeback-aware replacement policy to avoid the eviction of the dirty blocks that are highly reused after being evicted from the cache.
Our experimental results show that WALL achieves an average of 30.9% reduction in the total number of LLC writebacks, compared to the baseline scheme, which uses the LRU replacement policy. As a result, WALL can reduce the memory energy consumption by 23.1% and enhance PCM lifetime by 1.29×, on average, on an 8-core system with a 4GB PCM main memory, running memory-intensive applications.
Decreased electrogenic anionic secretory response in the porcine colon following in vivo challenge withBrachyspiraspp. supports an altered mucin environment
Authors: Enns Cole B. , Harding John C. S. , Loewen Matthew E. 
Published: January 2019

Brachyspira spp. cause diarrheal disease in multiple animal species by colonization of the colon, resulting in colitis, mucus induction, and disrupted ion transport. Unique to spirochete pathogenesis is the immense production of mucus, resulting in a niche mucin environment likely favoring spirochete colonization. Mucin rheological properties are heavily influenced by anionic secretion, and loss of secretory function has been implicated in diseases such as cystic fibrosis. Here, the effects on the agonist-induced electrogenic anionic secretory response by infectious colonic spirochete bacteria Brachyspira hyodysenteriae and Brachyspira hampsonii were assessed in the proximal, apex, and distal sections of colon in Ussing chambers. Activation of secretion via isoproterenol, carbachol, and forskolin/3-isobutyl-1-methylxanthine demonstrated a significantly decreased change in short-circuit current ( Isc) in Brachyspira-infected pigs in all sections. Tissue resistances did not account for this difference, rather, it was attributed to a decrease in anionic secretion as indicated by a decrease in bumetanide inhibitable Isc. Quantitative RT-PCR and Western blot analyses determined that the major anionic channels of the epithelium were downregulated in diarrheic pigs paired with altered mucin gene expression. The investigated cytokines were not responsible for the downregulation of anion channel gene transcripts. Although IL-1α was upregulated in all segments, it did not alter cystic fibrosis transmembrane conductance regulator (CFTR) mRNA expression in Caco-2 monolayers. However, a whole cell Brachyspira hampsonii lysate significantly reduced CFTR mRNA expression in Caco-2 monolayers. Together, these findings indicate that these two Brachyspira spp. may directly cause a decreased anionic secretory response in the porcine colon, supporting an altered mucin environment likely favoring spirochete colonization.NEW & NOTEWORTHY This research demonstrates for the first time that the niche mucin environment produced by two infectious spirochete spp. is supported by a decrease in the electrogenic anionic secretory response throughout the porcine colon. Our findings suggest that the host’s cytokine response is not likely responsible for the decrease in anionic secretory function. Rather, it appears that Brachyspira spp. directly impede ion channel transcription and translation, potentially altering colonic mucin rheological properties, which may favor spirochete colonization.
Two weeks of exercise training intensity on appetite regulation in obese adults with prediabetes
Authors: Heiston Emily M. , Eichner Natalie Z. M. , Gilbertson Nicole M. , Gaitán Julian M. , Kranz Sibylle , Weltman Arthur , Malin Steven K. 
Published: January 2019

No short-term exercise data exist testing whether training intensity modifies hormonal and perceived appetite in obese adults with prediabetes. Therefore, we compared the effects of short-term moderate-continuous (CONT) vs. high-intensity interval (INT) training on appetite regulation. Twenty-eight obese adults [age: 61.3 ± 1.5 yr; body mass index (BMI): 33.2 ± 1.1 kg/m2] with prediabetes were randomized to work-matched CONT ( n = 14) or INT ( n = 14) training for 2 wk. Plasma acylated ghrelin (AG), des-acylated ghrelin (dAG), active glucagon-like peptide-1 (GLP-1), and insulin were measured at 0, 30, and 60 min of a 75-g oral glucose tolerance test (OGTT) before and after training. Visual analog scales were administered at 0 and 120 min during the OGTT to examine perceived appetite. Three-day food logs were collected before and after testing to assess ad libitum diet. CONT and INT increased peak oxygen consumption ( P < 0.01) and decreased BMI ( P < 0.01). Although neither intervention altered fasting levels of AG ( P = 0.94), dAG ( P = 0.36), or insulin ( P = 0.67), CONT raised GLP-1 compared with INT ( P = 0.05). Exercise training did not affect postprandial suppression of AG ( P = 0.81) and dAG ( P = 0.67) or stimulation of GLP-1 ( P = 0.67) and insulin ( P = 0.32). Both interventions tended to decrease total energy and protein intake ( P = 0.09 and P = 0.05, respectively), despite no change in fasting hunger ( P = 0.88) and reduced perceived fullness at 120 min during the OGTT ( P = 0.05). We conclude that 2 wk of exercise training intensity does not modulate appetite-regulatory hormones in obese adults with prediabetes. Although perceived fullness to the OGTT was reduced after exercise, CONT and INT decreased energy intake, suggesting that exercise does not elicit compensatory appetite behavior to gain weight. NEW & NOTEWORTHY Adults with prediabetes are at risk for appetite dysregulation. Although exercise promotes weight management, it is unclear whether moderate-continuous or high-intensity interval training is more beneficial for appetite regulation. We show that 2 wk of exercise, independent of intensity, does not alter postprandial appetite hormones or hunger, despite slight reductions in food intake and weight. These data support exercise as an effective method to induce negative energy balance without compensatory weight gain.
Blinded and unblinded hypohydration similarly impair cycling time trial performance in the heat in trained cyclists
Authors: Funnell Mark P. , Mears Stephen A. , Bergin-Taylor Kurt , James Lewis J. 
Published: January 2019

Knowledge of hydration status may contribute to hypohydration-induced exercise performance decrements; therefore, this study compared blinded and unblinded hypohydration on cycling performance. Fourteen trained, nonheat-acclimated cyclists (age: 25 ± 5 yr; V̇o2peak: 63.3 ± 4.7 ml·kg−1·min−1; cycling experience: 6 ± 3 yr) were pair matched to blinded (B) or unblinded (UB) groups. After familiarization, subjects completed euhydrated (B-EUH; UB-EUH) and hypohydrated (B-HYP; UB-HYP) trials in the heat (31°C); 120-min cycling preload (50% Wpeak) and a time trial (~15 min). During the preload of all trials, 0.2 ml water·kg body mass−1 was ingested every 10 min, with additional water provided during EUH trials to match sweat losses. To blind the B group, a nasogastric tube was inserted in both trials and used to provide water in B-EUH. The preload induced similar ( P = 0.895) changes in body mass between groups (B-EUH: −0.6 ± 0.5%; B-HYP: −3.0 ± 0.5%; UB-EUH: −0.5 ± 0.3%; UB-HYP −3.0 ± 0.3%). All variables responded similarly between B and UB groups ( P ≥ 0.558), except thirst ( P = 0.004). Changes typical of hypohydration (increased heart rate, rating of perceived exertion, gastrointestinal temperature, serum osmolality and thirst, and decreased plasma volume; P ≤ 0.017) were apparent in HYP by 120 min. Time trial performance was similar between groups ( P = 0.710) and slower ( P ≤ 0.013) with HYP for B (B-EUH: 903 ± 89 s; B-HYP: 1,008 ± 121 s; −11.4%) and UB (UB-EUH: 874 ± 108 s; UB-HYP: 967 ± 170 s; −10.1%). Hypohydration of ~3% body mass impairs time trial performance in the heat, regardless of knowledge of hydration status. NEW & NOTEWORTHY This study demonstrates, for the first time, that knowledge of hydration status does not exacerbate the negative performance consequences of hypohydration when hypohydration is equivalent to ~3% body mass. This is pivotal for the interpretation of the many previous studies that have not blinded subjects to their hydration status and suggests that these previous studies are not likely to be confounded by the overtness of the methods used to induce hypohydration.
Safety and Efficacy of Nonanesthesiologist-Administrated Propofol during Endoscopic Submucosal Dissection of Gastric Epithelial Tumors
Authors: Abe Keiichiro , Tominaga Keiichi , Kanamori Akira , Suzuki Tsunehiro , Kino Hitoshi , Nakano Masakazu , Sugaya Takeshi , Tsuchida Kouhei , Majima Yuichi , Murohisa Toshimitsu , Iijima Makoto , Goda Kenichi , Irisawa Atsushi 
Published: January 2019

Objective. There is no consensus regarding administration of propofol for performing endoscopic submucosal dissection (ESD) in patients with comorbidities. The aim of this study was to evaluate the safety and efficacy of propofol-induced sedation administered by nonanesthesiologists during ESD of gastric cancer in patients with comorbidities classified according to the American Society of Anesthesiologists (ASA) physical status. Methods. Five hundred and twenty-two patients who underwent ESD for gastric epithelial tumors under sedation by nonanesthesiologist-administrated propofol between April 2011 and October 2017 at Dokkyo Medical University Hospital were enrolled in this study. The patients were divided into 3 groups according to the ASA physical status classification. Hypotension, desaturation, and bradycardia were evaluated as the adverse events associated with propofol. The safety of sedation by nonanesthesiologist-administrated propofol was measured as the primary outcome. Results. The patients were classified according to the ASA physical status classification: 182 with no comorbidity (ASA 1), 273 with mild comorbidity (ASA 2), and 67 with severe comorbidity (ASA 3). The median age of the patients with ASA physical status of 2/3 was higher than the median age of those with ASA physical status of 1. There was no significant difference in tumor characteristics, total amount of propofol used, or ESD procedure time, among the 3 groups. Adverse events related to propofol in the 522 patients were as follows: hypotension (systolic blood pressure<90 mmHg) in 113 patients (21.6%), respiratory depression (SpO2<90%) in 265 patients (50.8%), and bradycardia (pulse rate<50 bpm) in 39 patients (7.47%). There was no significant difference in the incidences of adverse events among the 3 groups during induction, maintenance, or recovery. No severe adverse event was reported. ASA 3 patients had a significantly longer mean length of hospital stay (8 days for ASA 1, 9 days for ASA 2, and 9 days for ASA 3, P=0.003). However, the difference did not appear to be clinically significant. Conclusions. Sedation by nonanesthesiologist-administrated propofol during ESD is safe and effective, even for at-risk patients according to the ASA physical status classification.
Bicuspid Aortic Valve Anatomy and Relationship With Devices: The BAVARD Multicenter Registry
Authors: Tchetche Didier , de Biase Chiara , van Gils Lennart , Parma Radoslaw , Ochala Andrzej , Lefevre Thierry , Hovasse Thomas , De Backer Ole , Sondergaard Lars , Bleiziffer Sabine , Lange Rudiger , Kornowski Ran , Landes Uri , Norgaard Bjarne Linde , Biasco Luigi , Philippart Raphaël , Molina-Martin de Nicolas Javier , Mylotte Darren , Lemee Caroline , Dumonteil Nicolas , Van Mieghem Nicolas M. 
Published: January 2019

Background:
Sizing for transcatheter aortic valve implantation in bicuspid aortic valves (BAV) remains controversial.

Methods and Results:

The aim of the BAVARD (Bicuspid Aortic Valve Anatomy and Relationship With Devices) retrospective registry is to capture the sizing ratios used for transcatheter aortic valve implantation in BAV and analyze the second-generation prostheses geometry postimplantation. About 101 patients with BAV along with available pre- and post-transcatheter aortic valve implantation multidetector computed tomography were compared with 88 tricuspid aortic valves (TAV) patients. Preprocedural multidetector computed tomography diagnosed type 0 and type 1 BAV in, respectively, 12.9% and 86.1 % of BAV. At baseline, the ellipticity index was similar between BAV and TAV patients: 1.2±0.1 versus 1.2±0.1,
P
=0.09. The mean annular oversizing was, respectively, 1.14±0.04 and 1.04±0.04,
P
<0.001, in TAV and BAV patients. The mean prosthesis intercommissural distance, ratio was 1.03±0.1. The mean diameter of the prostheses at the annulus matched the mean perimeter-derived diameter of the aortic annulus at baseline with TAV (23.3±2.2 versus 23.6±1.9,
P
=0.4) and was smaller with BAV (24±2.8 versus 26.8±3.1,
P
<0.01), confirming 11% underexpansion in BAV. Finally, in situ, prosthesis diameter and ellipticity followed the same pattern, with stable values from the distal edge to 12 mm above, in both groups.

Conclusions:
Second-generation prostheses similarly reshape the aortic annulus in TAV and BAV. Prostheses keep consistent diameters from distal edge to 12 mm in TAV and BAV. Prosthesis underexpansion is constantly observed in BAV. Annular-based sizing is accurate in BAV with minimal oversizing. The intercommissural distance, 4 mm above the annulus, could be integrated in gray zones.

Clinical Trial Registration:

URL:
https://www.clinicaltrials.gov
. Unique identifier: NCT03495050.
Short-Term Outcome of Ischemic Stroke Patients With Systemic Malignancy
Authors: Yoo Joonsang , Nam Hyo Suk , Kim Young Dae , Lee Hye Sun , Heo Ji Hoe 
Published: January 2019

Background and Purpose—
Recent guidelines have suggested the potential benefit of intravenous thrombolysis in stroke patients with systemic malignancy who have a reasonable life expectancy of >6 months. However, it is difficult to determine which patients with cancer will have a life expectancy of >6 months. Therefore, we identified the factors associated with 6-month mortality in patients with acute ischemic stroke and systemic malignancy.

Methods—
Consecutive stroke patients with systemic malignancy were retrospectively analyzed. We classified the patients into 3 groups: the nonactive cancer, active nonmetastatic cancer, and metastatic cancer groups. We compared the baseline characteristics and 6-month survival rates.

Results—
Of the 468 ischemic stroke patients with systemic malignancy during an 8-year period, 223 patients had nonactive cancer, 105 patients had active nonmetastatic cancer, and 140 patients had metastasis. During the 6-month follow-up, 122 patients (26.1%) died (nonactive cancer group [7.2%, 16/223], active nonmetastatic cancer group [11.4%, 12/105], and metastatic cancer group [67.1%, 94/140]). Multivariate Cox regression analysis revealed that the presence of metastasis (hazard ratio, 4.527; 95% CI, 2.175–9.422) was independently associated with 6-month mortality. However, the active nonmetastatic cancer group exhibited similar 6-month mortality to the nonactive cancer group (hazard ratio, 0.711; 95% CI, 0.282–1.795). Gastric/esophageal cancer and pancreatic cancer were also independently associated with 6-month mortality (hazard ratio, 2.068 and 2.389, respectively).

Conclusions—
In stroke patients with active cancer, the presence of metastasis and the cancer type were crucial factors associated with 6-month mortality.
Methylenetetrahydrofolate reductase C677T polymorphism and diabetic retinopathy risk: a meta-analysis of the Chinese population
Authors: Xu Wei-hai , Zhuang Ying , Han Xiao , Yuan Zhi-lan 
Published: January 2019

Objectives This study evaluated associations between methylenetetrahydrofolate reductase ( MTHFR) C677T polymorphisms and diabetic retinopathy (DR) susceptibility within the Chinese population. Methods Five databases (PubMed, EMBASE, Web of Science, Cochrane Library, Chinese National Knowledge Infrastructure) were used for literature searches of open access articles from inception through April 2017. Results Eight publications were identified involving 600 DR cases, 363 healthy controls, and 646 nondiabetic retinopathy (NDR) controls. There was a positive association between MTHFR C677T polymorphisms and DR risk within the Chinese population (DR with NDR controls: T vs. C, odds ratio (OR): 2.14, 95% confidence interval (CI): 1.55–2.97; TT vs. CC, OR: 4.19, 95% CI: 2.09–8.41; TT + CT vs. CC, OR: 2.83, 95% CI: 1.86–4.40; TT vs. CC + CT, OR: 2.48, 95% CI: 1.52–4.05. DR with healthy controls: T vs. C, OR: 2.48, 95% CI: 1.99–3.09; TT vs. CC, OR: 4.92, 95% CI: 3.18–7.62; TT + CT vs. CC, OR: 3.22, 95% CI: 2.32–4.48; TT vs. CC + CT, OR: 3.11, 95% CI: 1.83–5.28). The association was similar in South China and North China, when stratifying by geographic areas. Conclusion MTHFR C677T polymorphisms increase DR risk within the Chinese population.
Precise differential diagnosis of acute bone marrow edema and hemorrhage and trabecular microfractures using naïve and gamma correction pinhole bone scans
Authors: Bahk Yong-Whee , Edmund Kim E. , Chung Yong-An , Park Jung Mee , Jeon Jeong Yong , Jeong Hyeonseok 
Published: January 2019

Objective To analyze the performance of sequential naïve pinhole bone scan (nPBS) and gamma correction pinhole bone scan (GCPBS), reinforced by ImageJ densitometry and pixelized microfracture measurement, for making specific diagnoses of bone marrow edema (BME), bone marrow hemorrhage (BMH), and trabecular microfractures (TMF). Methods We prospectively examined BME, BMH, TMF, and normal trabeculae in 10 patients using sequential nPBS and GCPBS. The intensity of 99mtechnetium-hydroxydiphosphonate (99mTc-HDP) uptake was measured using a pixelized method and calculated using ImageJ densitometry in terms of arbitrary units (AU). This overall method was termed a visuospatial-mathematic assay (VSMA). We analyzed the ability of the calculated AU values to discriminate between the four states using GraphPad Prism software, with reference to previous morphological data. Results The calculated values were categorized as ≤50 AU for normal trabecula, 51–100 AU for BME, 101–150 AU for BMH, and ≥151 AU for TMF. The difference in uptake between normal trabecula and BME was significant and the differences among BME, BMH, and TMF were highly significant. Conclusion VSMA is a useful technique for refining objective individual diagnoses and for differentiating and quantitating BME, BMH, and TMF.
Convergence of Mortality Among African Americans
Authors: Naghshpour Shahdad , Sameem Sediq 
Published: January 2019

The purpose of this study is to explore any possible convergence in African American mortality rates in the United States. Using county-level data of the United States over a period of nearly five decades (1968-2015), the findings indicate that β-convergence has occurred in mortality rates of African American population implying that their mortality rates are getting closer to their means. The results are particularly stronger for females and the elderly. The findings reflect lower cost of implementation and dissemination of strategies that would target the health of such population. JEL Classifications: II0, I30, R10
Carbon Fibre-Copper Composites Made by Volumetric Bonding.
Authors: Włosinski W. , Kalinski D. , Olesinska W. , Pietrzak K. 
Published: January 2019

Abstract. The results of investigation on forming copper-carbon fibre composite were presented. A new method of vacuum volumetric bonding was elaborated for this purpose. The copper-carbon fibre composites were processed at temperatures between 750 and 1050°C under pressures of 30 to 60 MPa and times ranging from 15 to 60 minutes. The composite microstructure was found to be homogeneous, the measured density varied from 6.58 up to 7.8 g/cm3 and the hardness ranged from 63 to 113 HB (KG/mm2).