bluuebunny/crossref_metadata_2025_split huggingface dataset:
EchoApex: A General-Purpose Vision Foundation Model for Echocardiography
Authors: Zhang Yue , Amadou Abdoul , Piat Sebastien , Klein Paul , Schmuecking Ingo , Passerini Tiziano , Sharma Puneet 
Published: December 2024

Abstract

Quantitative evaluation of echocardiography is essential for precise assessment of cardiac condition and guiding treatment decisions. The diverse nature of echo images, including variations in probe types, manufacturers, and pathologies, poses challenges for developing artificial intelligent models that can generalize across different clinical practice. Here, we introduce EchoApex, a general-purpose vision foundation model designed for comprehensive echocardiography analysis. Pretrained on over 20 million images from 11 clinical centers, EchoApex utilizes self-supervised learning and task-specific decoders for diverse applications in echocardiography. It performs sequence view classification, interactive structure segmentation, left ventricle measurement, and ejection fraction estimation. In benchmark evaluations, EchoApex outperforms task-specific models, achieving a mean BACC of 0.976 in classification of 18 common views, DICE of 0.93 in chamber segmentation, MAE of 3.9mm in left ventricle linear measurement and a zero-shot performance improvement over specialist models in all evaluated datasets. For ejection fraction estimation, EchoApex achieves an MAE of 5.6% and an AUC of 0.927 for cardiomyopathy detection. Despite using less than 4% of trainable parameters with frozen encoders, EchoApex with adapter demonstrates strong performance with minimal degradation compared to fully finetuned models. This work establishes EchoApex as a scalable, general-purpose model for echocardiography, enabling efficient adaptation across various clinical tasks.
Estimation of biogas production by LandGEM model and energy recovery potential from municipal solid waste Landfill of Kermanshah, Iran
Authors: Jafari Ali , Nourozi Nasim , Nayeri Danial 
Published: December 2024

Abstract

Nowadays, landfill gases (LFGs) such as methane (CH4), carbon dioxide (CO2) and nonmethane organic compounds (NMOCs) have been considered as the main source of greenhouse gases made by human. Herein, due to the importance, LFGs emission and the energy generation potential of an uncontrolled landfill site, located in Kermanshah, was estimated using LandGEM (3.02) from 2024-2054. In this work electric power generation capacity was estimated by calculating annual production of electric energy (kWh/year) generated for methane emissions from the beginning of landfilling to the end of designed period (30 years). The results indicated that CH4, CO2, and NMOCs emitted from the landfill will peak in 2055 with values of 2.2E+04, 6.0E+04 and 9.4E+02 Mg/year, respectively. The waste production of 285.4 million kg/day is able to provide about 8.8E+07 kWh energy, which will be 0.36% of energy consumption in Kermanshah city in 2054. The results demonstrate a significant energy potential and are very promising. Further, it was estimated that maximum total electricity production of 8.9E+07 kWh will be attained in 2055.
Changes in cerebral blood flow during parabolic flight
Authors: Wollseiffen Petra , Schneider Stefan , Mandic Mirco , Badalì Constance 
Published: December 2024

Abstract

A number of studies have well described central cardiovascular changes caused by changing gravity levels as they occur e.g. during parabolic flight. However limited data exists describing the effect of microgravity on the cerebrovascular system and brain perfusion, which might heavily affect the intracranial pressure (ICP). In this study, performed on board the Airbus A310 ZeroG, cerebral blood flow velocity, diameter and cerebral blood volume were continuously monitored in the arteria carotis communis (ACC) for five consecutive parabolas by cardiac-gated B mode ultrasonography using a 7–12MHz linear transducer. Simultaneously heart rate (HR) was monitored. Data was assessed in the 1G condition pre parabola and at the start and end of each 1.8G and 0G phase. A lab-based study was administered where participants repeatedly changed between a seated and six-degree head down tilt (HDT) position for 20 seconds. During parabolic flight, HR increased during the two hypergravity phases and decreased back to 1G baseline in the weightlessness phase of the parabola. ACC diameter, blood flow velocity and flow volume showed a clear decrease in the first 1.8 hypergravity phase but returned to 1G baseline in the microgravity phase. Different results were obtained by changing from a seated to a 6°HDT position, resulting in an increase in ACC diameter, flow velocity and flow volume. Results suggest that the previously described changes within the middle cerebral artery (MCA) are rather caused by changes on the venous side but not an increased inflow during – at least – short term phases of microgravity.
Negative Pressure Suction in ERCP Brush Cytology: Assessing its Impact on Biliary Stricture Diagnostics
Authors: Ying， Huajie , Ying Xiaodan , Lu Fangyan , huang Feiyan 
Published: December 2024

Abstract

Objective: To evaluate the effectiveness of negative pressure suction in improving the diagnostic yield of brush cytology for biliary strictures.
Methods: We conducted a prospective study on 48 patients undergoing ERCP. Participants were divided into two groups: those undergoing standard brush cytology (CP group) and those with additional negative pressure suction (NP group). The diagnostic yield of brush cytology and liquid-based cytology were compared, with an emphasis on assessing the independent predictive value of negative pressure and CA125.
Results: The application of negative pressure significantly improved the positive diagnosis rate of liquid-based cytology to 75%, compared to standard brush cytology. No significant correlations were found with the length of the biliary stricture. Multivariate analysis revealed negative pressure (OR: 5.4; 95% CI: 1.18–29; p = 0.034) and CA125 (OR: 4.80; 95% CI: 1.07–25.27; p = 0.047) as independent predictors. The predictive model achieved an AUC of 0.823, suggesting a substantial enhancement in diagnostic accuracy.
Conclusions: Negative pressure suction in brush cytology presents as a superior technique for the diagnosis of biliary strictures, offering a safer and more efficacious alternative to invasive biopsy methods.
F3 expression drives sensitivity to the antibody-drug conjugate tisotumab vedotin in glioblastoma
Authors: Sears Thomas K. , Wang Wenxia , Drumm Michael , Unruh Dusten , McCord Matthew , Horbinski Craig 
Published: December 2024

Abstract

Purpose
The gene F3, encoding Tissue Factor (TF), is expressed in many cancers and contributes to their malignancy. Among adult-type diffuse gliomas, IDH wild-type (IDHwt) glioblastomas (GBM) express more TF than IDH mutant (IDHmut) gliomas. Tisotumab vedotin (TisVed), an anti-TF antibody conjugated to monomethyl auristatin E, is a therapeutic designed to target cells expressing TF. We therefore sought to determine the therapeutic potential of TisVed in IDHwt vs. IDHmut gliomas.
Methods
We treated IDHwt and IDHmut patient-derived glioma cells with control IgG, unconjugated tisotumab (Tis), or TisVed in vitro, followed by cell viability assays and assessment of TF signaling. We tested Tis and TisVed in mice intracranially engrafted with patient-derived IDHwt and IDHmut gliomas and mice flank-engrafted with IDHwt GBM.
Results
TisVed was more active against cultured IDHwt GBM cells than IDHmut glioma cells. This activity was increased by daily washout of soluble TF secreted by IDHwt GBM cells. Unconjugated Tis had less effect than TisVed, and TF signaling was minimally inhibited. TisVed extended the survival of mice intracranially engrafted with IDHwt GBM (P = 0.006), but not mice with IDHmut glioma (P = 0.88). TisVed also reduced the growth of IDHwt GBM flank xenografts. Tis had no antitumor effect in either setting. Both TisVed and Tis caused hemorrhage in flank tumors.
Conclusions
TisVed targets high TF-expressing IDHwt GBM, but not low TF-expressing IDHmut glioma. This is predominately through the vedotin conjugate rather than inhibition of TF signaling. Though the effect size is modest, TisVed may therefore be a new strategy against IDHwt GBM. Additionally, complications related to hemostasis may be an issue.
Factors Influencing Morbidity, Mortality, and Survival in Lymphoma Patients: A Population-Based Study from Xiamen, China
Authors: Luo Wenting , Zhang Xiangdong , Li Xingyu , Chi Jiahuang , Luo Yanxin , Zhuang Xingou , Lin Yilan 
Published: December 2024

Abstract

Objective The aim of this study was to analyze the factors influencing morbidity, mortality and survival outcomes in patients diagnosed with lymphoma. Methods Data were collected from all newly diagnosed lymphoma cases in Xiamen City between 2011 and 2020. The data were evaluated to assess morbidity and mortality rates, with statistical analyses conducted using SAS 9.4 software. Results The results of this study indicated that the incidence rate of lymphoma is higher in males than in females and higher in urban areas than in rural ones (ASIR 6.44 per 100 000 versus 4.34 per 100 000), the lymphoma mortality rate is higher in males than in females (ASMR 3.57 per 100 000 versus 2.10 per 100 000) and greater in urban areas compared to rural areas(ASIR 3.14 per 100 000 versus 2.10 per 100 000). Six variables (age, suburb, marital status, education, lymphoma type, and diagnosis year) significantly impacted prognosis, as shown by the multivariate Cox analysis. Conclusion Developing lymphoma prevention and control programs for people of different genders, ages, living environments, and literacy levels can effectively reduce lymphoma morbidity and mortality and improve survival.
Demographics, Prognostic Factors and Survival Outcomes in Hepatic Angiosarcoma: A Retrospective Analysis
Authors: Robinson Jaylyn , Iqbal Asif , Yasinzai Abdul Qahar Khan , Sohail Amir Humza , Jain Hritvik ,   Noorana Fdhil2 Fadhil, Khan Marjan , Khan Israr , Karki Nabin Raj , Ullah Asad 
Published: December 2024

Abstract

Background
Hepatic angiosarcoma (HA) is a rare malignant vascular neoplasm. Currently, there are no standardized protocols for treating HA. This study aims to comprehensively understand clinicopathologic analysis, prognostic factors, treatment outcomes, and genetic mutations for personalized treatment associated with HA.
Methods
The data retrieved from the SEER database was reviewed for hepatic angiosarcoma cases between 2000–2021.
Results
A total of 389 patients with hepatic angiosarcoma were identified with a mean age of 63.9 years (SD ± 16). Most patients were male (64%), and per US census data, non-Hispanic Asians or Pacific Islanders were the most common race (17%). In known cases of tumor stage (61%), the most common tumor stage was distant (22%), and most were grade III (18%) tumors. Overall, the 3-year survival rate was 6.7% with a 95% confidence interval (95% CI, 0.044-0.100), disease-specific survival at a 1-year survival rate was 4.43% (95% CI, 0.023–0.083) and no patients survived by 3 years. The best overall survival rate was the 1-year rate for surgical resection, 18.20% (95% CI: (0.075–0.441). Chemotherapy had a 1-year survival rate of 11% (95% CI, 0.057–0.211), and radiation therapy had no survival significance (p = 0.2). Multivariate analysis shows age above 70 years (H.R. 1.67 (95% CI, 1.181–2.381), p < 0.05), no surgical intervention (H.R. 2.29 (95% CI, 1.585–3.336) p < 0.001), and distant stage (H.R. 2.54 (95% CI, 1.696–3.805) p < 0.001) are negative prognostic factors, whereas female sex (H.R. 0.68 (95% CI, 0.536–0.875) p < 0.05) is a positive prognostic factor.
Conclusion
Increasing age (> 70 years), male sex, and distant stage were found to be strong predictors of poor survival outcomes. Patients had better outcomes when surgical resection and chemotherapy were included in their treatment. These results can provide continued evidence in the future management of patients with hepatic angiosarcoma.
Integrated analysis to find MicroRNAs and Genes Associated with Metastasis and Cisplatin and 5-Fluorouracil Resistance Gastric Cancer
Authors: Iranmehr Zahra , Yasavoli-Sharahi Hamed , Ghaemi Fatemeh , Miri Seyed Rouhollah , ebrahimi marzieh 
Published: December 2024

Abstract

Background
Metastasis and drug resistance are the leading causes of cancer-related mortality worldwide. Studies suggest that epigenetic factors play a crucial role in these common complications.
Objective
This study aimed to identify key regulators of drug resistance and metastasis in gastric cancer by utilizing a combined in silico and in vitro approach. The goal was to uncover genes and microRNAs that could serve as determining factors and patterns in chemoresistance to common chemotherapy drugs and metastasis.
Materials and Method
The expression profile of genes that differed between drug resistance and sensitive gastric cancer patients was obtained from the GEO database. Then protein-protein interactions were provided using Cytoscape software. The selected genes were assessed for differences in gastric cancer and normal tissues using the Gepia website. Then, the MiRWalk database searched to find regulating microRNAs. MKN-45 cells were treated with Cisplatin (CCDP) and 5-Fluorouracil (5-FU) two times. Finally, the evaluation of selected genes and micro-RNAs in non-metastatic and metastatic tissues and 5-FU/CCDP resistance MKN-45.
Results
Data revealed 28 genes differentially expressed between drug-resistant and drug-sensitive gastric cancer, exhibiting differences in both normal and tumor tissues. Protein interaction analysis highlighted CXCL8, MMP9, CCL5, and STAT1; as crucial genes influencing both metastasis and drug resistance in gastric cancer patients. Moreover, miR-17-5p, miR-24-3p, miR-124-3p, miR-128, and miR-145-3p were introduced here which play important roles in regulating both processes. The expression levels of CXCL8, STAT1, miR-17-5p, miR-24-3p, miR-124-3p increased, and miR-145-3p decreased significantly in metastatic tissues and 5-FU/CCDP resistant MKN45 than non-metastatic and sensitive ones.
Conclusion
Up-regulation of miR-17-5p, miR-24-3p, miR-124-3p, CXCL8, CCL5, MMP9, and STAT1 is implicated in metastasis and drug resistance to both cisplatin and 5-FU. Also, down-regulation of miR-145-3p induces metastasis and drug resistance possibly via STAT1 and MMP9.
Intensification of extreme cold events in East Asia in response to global mean sea-level rise
Authors: Zhang Zhongshi , dong caoyi , Keenlyside Noel , Sobolowski Stefan , Otterå Odd Helge , Bonaduce Antonio , Xie Jiping , Raj Roshin , Liu Yong , Liu Bo , Wu Mingna 
Published: December 2024

Abstract

Today, the global mean sea level(GMSL) stands ~20cm higher than at the beginning of the last century, and the rate of sea-level rise has been accelerating in recent decades. Even a slight, globally uniform sea-level rise can notably impact atmospheric and oceanic circulations at climatic and potentially synoptic scales. However, the extent to which sea-level rise will influence extreme weather remains largely unknown. Here, we specifically focused on East Asia and conducted experiments to investigate the effects of GMSL rise. Our experiments demonstrate that GMSL rise, even in tens of centimeters, promotes stronger and more frequent extreme cold events. This effect is attributed to weakened mid-latitude westerly winds and increased occurrence of blocking events over Eurasia. Our study presents the first evidence that GMSL rise will modify synoptic systems and intensify extreme events. Both coastal and inland countries are exposed to threats arising from GMSL rise.
FinTechFake: A Linguistic-Enabled Artificial Intelligence Approach for Detecting Fake News in Finance
Authors: Meraj Mohd , Kamal Ahmad 
Published: December 2024

Abstract

The spread of misleading information on social media and internet forums has posed a serious danger to organizations and enterprises. This paper proposes an ensemble learning-based artificial intelligence approach called FinTechFake for financial fake news detection. Due to the public unavailability of the financial fake news dataset, we created a financial fake news dataset from the existing benchmark fake news dataset using topic modeling approaches. Substantial feature engineering has been investigated to extract the best-suited linguistic aspects that include sentence cohesion, stance, sentiment, and other grammatical features. Furthermore, linguistic features are combined with word embedding-based characteristics to apply an ensemble learning approach for the automatic detection of financial fake news from large text corpora. In terms of classification accuracy, both XGBoost and LGBM produce good results with 96.8% accuracy. When compared with the existing state-of-the-art, FinTechFake, outperformed others in terms of F1 score by 2.6%.
Association between adverse childhood experiences and post-COVID-19 conditions: Evidence from 27 countries
Authors: Zong Xu 
Published: December 2024

Abstract

The association of Adverse childhood experiences (ACEs) with post-COVID-19 conditions among older adults remains unclear. The study used cross-national samples of 27 countries to examine the association between ACEs and post-COVID-19 conditions among European and Israeli older adults. Our results suggest that moderate ACE exposure (2 ACEs) may be associated with lower odds of post-COVID-19 conditions in later life. Among specific ACEs, neglect by parents was associated with lower odds of post-COVID-19 conditions.
Analysis of Factors Driving the Acceptability of a Low Emission Zone
Authors: Gastaldi Massimiliano , Ceccato Riccardo , Rossi Riccardo 
Published: December 2024

Background
In many cities worldwide, a Low Emission Zone has been introduced with the aim to improve livability of urban areas and foster sustainable mobility habits. However, a limited or absent public support has proven to hinder the implementation of such intervention or negatively impact its effectiveness.

Objective
This paper aims to understand factors prompting and hindering acceptability of a Low Emission Zone in a medium-sized city.

Methods
The study area was the city of Padova (Italy), where a potential future shift from the current limited traffic zone toward a Low Emission Zone was investigated. A mobility questionnaire administered to stakeholders of the intervention area. Data collected were used as input of an integrated set of statistical models. A factor analysis was implemented to highlight the underlying structure of respondents’ opinion about the Low Emission Zone. A cluster analysis was used to define stakeholders' profiles, and an ordinal logit model was developed to identify factors affecting the support of the new regulation.

Results
Results pointed out profiles of both supporters and opposers to the measure. To effectively improve public support, potential benefits of the current Limited Traffic Zone and how the Low Emission Zone aims to enhance them could be highlighted. As expected, the highest opposition could stem from car users, who should be targeted with specific strategies to increase their acceptability level.

Conclusions
The analysis highlighted how policy makers and local authorities can foster the widest support of the new Low Emission Zone and thus broadening its potential benefits.
THE EFFECT OF LEADERSHIP AND INTERNAL COMMUNICATION ON JOB SATISFACTION AT PDAM TIRTA GIRI NATA, CIREBON CITY
Authors: Atiana Sari 
Published: December 2024

The purpose of this study is to investigate how internal communication and leadership affect work satisfaction at PERUMDA Tirta Giri Nata in Cirebon City. This study's research methodology is a quantitative approach. With a sample of 66 workers, the population under study consisted of 190 employees of PERUMDA Tirta Giri Nata Cirebon City. A questionnaire was employed for data collection, and multiple analytic regressions were used to analyze the data. The study's findings demonstrated that leadership and internal communication were positively and significantly impacted at the same time. Internal communication had a positive and substantial impact on job satisfaction with a value of (2,296 1.99773) and a significant value of (0.025 0.05), whereas work on job satisfaction had a calculated value of (10,046 1,99773) and a significant value of (0.000 0.05). The F test, which was derived from the test results of 79.179 3.140 and a significant value of 0.000 0.05, revealed the simultaneous test between leadership and internal communication on job satisfaction at PDAM Tirta Giri Nata Cirebon City. This indicates that both leadership and internal communication had a positive and significant impact on job satisfaction.
Penguatan Kesadaran Wisata Melalui Program Sapta Pesona di Desa Wisata
Authors: Trihayuningtyas Endah , Zulhelfa Zulhelfa , Reyaan Alexander , Elmia Arini Shofi 
Published: December 2024

Keberhasilan pembangunan pariwisata melibatkan partisipasi masyarakat karena dapat memberikan manfaat bagi masyarakat lokal baik dari segi ekonomi, sosial, dan budaya. Desa Karangsambung yang berada di Kecamatan Karangsambung, merupakan salah satu Desa yang terletak di sebelah utara Kota Kebumen. Berdasarkan potensi yang dimiliki oleh Desa Karangsambung, maka masyarakat harus memahami tentang konsep sapta pesona. Untuk mendukung hal tersebut, perlu dilakukan Program Pengabdian Masyarakat dalam bentuk ceramah dan diskusi. Program ini menggunakan pendekatan sosialisasi dan pelatihan yang melibatkan 20 peserta dari berbagai elemen masyarakat. Melalui metode ceramah dan diskusi kelompok, peserta diajak untuk memahami dan menerapkan prinsip Sapta Pesona. Hasil evaluasi menunjukkan peningkatan pemahaman yang signifikan pada aspek Ramah dan Sejuk, sementara aspek Bersih dan Tertib masih memerlukan perhatian lebih lanjut. Program ini berhasil meningkatkan kesadaran wisata dan memberikan rekomendasi untuk pengembangan lebih lanjut.

Successful tourism development involves community participation because it can provide benefits to local communities both in economic, social and cultural terms. Karangsambung Village, which is in Karangsambung District, is one of the villages located in the north of Kebumen City. Based on the potential of Karangsambung Village, the community must understand the concept of Sapta Pesona. To support this, it is necessary to carry out a Community Service Program in the form of discussions. This program uses a socialization and training approach involving 20 participants from various elements of society. Through lecture and group discussion methods, participants are invited to understand and apply the principles of Sapta Pesona. The evaluation results showed a significant increase in understanding in the Friendly and Cool aspects, while the Clean and Orderly aspects still require further attention. This program has succeeded in increasing tourism awareness and providing recommendations for further development.