bluuebunny/crossref_metadata_2025_split huggingface dataset:
Understanding chondrodysplasia (cho): A comprehensive review of cho as an animal model of birth defects, disorders, and molecular mechanisms
Authors: Seegmiller Robert E. , Foster Cameron , Burnham Jared L. 
Published: February 2019

BackgroundThe mutant chondrodysplasia (cho) is a cartilage‐targeting disorder in C57BL mice that results in dwarfing and other malformations stemming from this collagenopathy. Clarke Fraser made the discovery of the mutation accidentally in the early 1960s during the thalidomide tragedy.MethodsFor this review we identified key research on cho as since its discovery. Relevant data were compiled to make a comprehensive review that details discoveries associated with the cho mutation, that describes the associated phenotypes and molecular mechanisms, and that provides a discussion surrounding its current clinical relevance.ResultsMechanistically, cho acts by hindering chondrogenesis and endochondral bone formation. The phenotype results from a 1‐nt deletion in the gene encoding the alpha 1 chain of type XI collagen. For more than half a century, researchers have studied the pathogenesis of the cho mutation in relation to a variety of mouse models of human birth defects and disease. These studies have resulted in several discoveries linking cho with such human disorders as dwarfism, tracheal stenosis, cleft palate, pulmonary hypoplasia, and osteoarthritis (OA).ConclusionThe study of cho has led to numerous advances in understanding human birth defects, congenital disorders, and adult human disease. The most recent studies have suggested a role for the TGF‐Beta, HtrA1, Ddr2, and Mmp‐13 pathway in the degradation of articular cartilage and the development of OA in cho/+ mice. We have shown that the anti‐hypertension drug Losartan is a TGF‐Beta blocker that could be used to treat OA in Stickler syndrome, and thereby rescue the WT phenotype.
Manipulating Active Structure and Function of Cationic Antimicrobial Peptide CM15 with the Polysulfonated Drug Suramin: A Step Closer to in Vivo Complexity
Authors: Quemé‐Peña Mayra , Juhász Tünde , Mihály Judith , Cs. Szigyártó Imola , Horváti Kata , Bősze Szilvia , Henczkó Judit , Pályi Bernadett , Németh Csaba , Varga Zoltán , Zsila Ferenc , Beke‐Somfai Tamás 
Published: February 2019

AbstractAntimicrobial peptides (AMPs) kill bacteria by targeting their membranes through various mechanisms involving peptide assembly, often coupled with disorder‐to‐order structural transition. However, for several AMPs, similar conformational changes in cases in which small organic compounds of both endogenous and exogenous origin have induced folded peptide conformations have recently been reported. Thus, the function of AMPs and of natural host defence peptides can be significantly affected by the local complex molecular environment in vivo; nonetheless, this area is hardly explored. To address the relevance of such interactions with regard to structure and function, we have tested the effects of the therapeutic drug suramin on the membrane activity and antibacterial efficiency of CM15, a potent hybrid AMP. The results provided insight into a dynamic system in which peptide interaction with lipid bilayers is interfered with by the competitive binding of CM15 to suramin, resulting in an equilibrium dependent on peptide‐to‐drug ratio and vesicle surface charge. In vitro bacterial tests showed that when CM15⋅suramin complex formation dominates over membrane binding, antimicrobial activity is abolished. On the basis of this case study, it is proposed that small‐molecule secondary structure regulators can modify AMP function and that this should be considered and could potentially be exploited in future development of AMP‐based antimicrobial agents.
In vivo validation of Dosemap software use in interventional cardiology with dosimetrics indicators and peak skin dose evaluation
Authors: Didier Romain , Bourhis David , Oueslati Chaker , Nasr Bahaa , Le Ven Florent , Noël Antoine , Jobic Yannick , Damien Pascal , Pene‐Baverez Dominique , Mansourati Jacques , Nicol Pierre Philippe , Gilard Martine 
Published: February 2019

AbstractObjectivesThe aim of this study was to determine the accuracy of DoseMap™ software as compared to gafchromic film in real clinical practices.BackgroundThe radiation exposure from cardiovascular procedures could expose patients to potential risk of cancer and/or skin injury. New tools like Dosemap software were developed to estimate the patient skin dose in the cardiac catheterization laboratory. However, little data are available to validate this estimation of patient radiation skin dose.MethodsThis is a prospective cross‐sectional study comparing the peak skin dose (PSD) measured by gafchromic film used as reference with an estimated PSD given by Dosemap software, in patients with BMI > 30 kg/m2 undergoing elective diagnostic and/or therapeutic interventional cardiology procedures, from April 2016 to December 2016, at the Brest University Hospital Centre, France.ResultsAfter four exclusions of patients for poor quality of gafchromic films, 90 patients were included, with 58 angiography (67.4%), 14 percutaneous interventions (16.3%), and 14 both (16.3%). The median PSDDosemap and PSDFilm were similar with 157 mGy [IQR: 99; 273] versus 158 mGy [IQR: 101; 295] (P = 0.65), respectively, with an excellent correlation (r = 0.95). The comparison between cumulative air kerma and PSDFilm was different 366 mGy [IQR: 246; 575] versus 158 mGy [IQR: 101; 295] (P < 0.01) with moderate correlation (r = 0.79). No correlation was found between the dose area product and PSDFilm (r = 0.51).ConclusionDoseMap is an effective and valid method as compared to gafchromic films to estimate PSDs during interventional cardiologic procedures.
Highly‐Branched Palladium Nanodandelions: Simple, Fast, and Green Fabrication with Superior Oxygen Reduction Property
Authors: Fan Chuang , Huang Zihan , Wang Chao , Hu Xianyu , Qiu Xiaoyu , She Peiliang , Sun Dongmei , Tang Yawen 
Published: February 2019

AbstractControllable synthesis of highly‐branched metallic structures is of great interest and broad significance for their unique properties of superior conductivity, high porosity, low density, etc., that promote the development of high‐efficiency electrocatalysts. Herein, a simple, rapid and green method for the synthesis of highly‐branched palladium nanodandelions with flexible ultrafine tentacles and bumpy superficial atomic steps is investigated, without the demand of elevated temperature, seed, template, prolonged reaction time and any organically toxic reducing agent from previously reported highly‐branched nanostructures. For the first time, N,N′‐methylenebisacrylamide (MBAA) serves as the only additive to simultaneously cover the functions of coordinating agent, reducing agent, and structure‐directing agent, facilitating the strategy of intramolecular coordination and self‐reduction. Derived from their plentiful ultrafine tentacles, porosity due to the highly‐branched structure, and abundant surface atom steps, the Pd nanodandelions exhibit a more positive half‐wave of 0.863 V (vs. RHE), optimized specific kinetic activity of 3.0 mA cm−2 at 0.9 V, and better cycle stability with a maintenance of 77.8 % after 20000 s for the oxygen reduction reaction (ORR), when compared to commercial Pd black. The architectural design of highly‐branched metallic structures, as well as the smart fabrication strategy, may hold great promise for exploring a variety of functional nanomaterials.
Molecular Basis of the Chemiluminescence Mechanism of Luminol
Authors: Giussani Angelo , Farahani Pooria , Martínez‐Muñoz Daniel , Lundberg Marcus , Lindh Roland , Roca‐Sanjuán Daniel 
Published: February 2019

AbstractLight emission from luminol is probably one of the most popular chemiluminescence reactions due to its use in forensic science, and has recently displayed promising applications for the treatment of cancer in deep tissues. The mechanism is, however, very complex and distinct possibilities have been proposed. By efficiently combining DFT and CASPT2 methodologies, the chemiluminescence mechanism has been studied in three steps: 1) luminol oxygenation to generate the chemiluminophore, 2) a chemiexcitation step, and 3) generation of the light emitter. The findings demonstrate that the luminol double‐deprotonated dianion activates molecular oxygen, diazaquinone is not formed, and the chemiluminophore is formed through the concerted addition of oxygen and concerted elimination of nitrogen. The peroxide bond, in comparison to other isoelectronic chemical functionalities (−NH−NH−, −N−−N−−, and −S−S−), is found to have the best chemiexcitation efficiency, which allows the oxygenation requirement to be rationalized and establishes general design principles for the chemiluminescence efficiency. Electron transfer from the aniline ring to the OO bond promotes the excitation process to create an excited state that is not the chemiluminescent species. To produce the light emitter, proton transfer between the amino and carbonyl groups must occur; this requires highly localized vibrational energy during chemiexcitation.
Advantageous Interfacial Effects of AgPd/g‐C3N4 for Photocatalytic Hydrogen Evolution: Electronic Structure and H2O Dissociation
Authors: Zou Weixin , Xu Lixia , Pu Yu , Cai Haojie , Wei Xiaoqian , Luo Yidan , Li Lulu , Gao Bin , Wan Haiqin , Dong Lin 
Published: February 2019

AbstractBimetallic AgPd nanoparticles have been synthesized before, but the interfacial electronic effects of AgPd on the photocatalytic performance have been investigated less. In this work, the results of hydrogen evolution suggest that the bimetallic AgPd/g‐C3N4 sample has superior activity to Ag/g‐C3N4 and Pd/g‐C3N4 photocatalysts. The UV/Vis diffuse reflectance spectroscopy, X‐ray photoelectron spectroscopy, CO adsorption diffuse reflectance FTIR spectroscopy, and FTIR results demonstrate that in the AgPd/g‐C3N4, the surface electronic structures of Pd and Ag are changed, which is beneficial for faster photogenerated electron transfer and greater H2O molecule adsorption. In situ ESR spectra suggest that, under visible light irradiation, there is more H2O dissociation to radical species on the AgPd/g‐C3N4 photocatalyst. Furthermore, DFT calculations confirm the interfacial electronic effects of AgPd/g‐C3N4, that is, Pdδ−⋅⋅⋅Agδ+, and the activation energy of H2O molecule dissociation on AgPd/g‐C3N4 is the lowest, which is the main contributor to the enhanced photocatalytic H2 evolution.
In Situ Enzyme Immobilization with Oxygen‐Sensitive Luminescent Metal–Organic Frameworks to Realize “All‐in‐One” Multifunctions
Authors: Xu Yuzhi , Liu Si‐Yang , Liu Junling , Zhang Li , Chen Danping , Chen Jun , Ma Yingjun , Zhang Jie‐Peng , Dai Zong , Zou Xiaoyong 
Published: February 2019

AbstractMetal–organic frameworks (MOFs) for enzyme immobilization have already shown superior tunable and designable characteristics, however, their diverse responsive properties have rarely been exploited. In this work we integrated a responsive MOF into a MOF–enzyme composite with the purpose of designing an “all‐in‐one” multifunctional composite with catalytic and luminescence functions incorporated into a single particle. As a proof‐of‐concept, glucose oxidase (GOx) was encapsulated in situ within an oxygen (O2)‐sensitive, noble‐metal‐free, luminescent CuItriazolate framework (MAF‐2), denoted as GOx@MAF‐2. Owing to the rigid scaffold of MAF‐2 and confinement effect, the GOx@MAF‐2 composite showed significantly improved stability (shelf life of 60 days and heat resistance up to 80 °C) as well as good selectivity and recyclability. More importantly, owing to the O2sensitivity of MAF‐2, the GOx@MAF‐2 composite exhibited a rapid and reversible response towards dissolved O2, thereby allowing direct and ratiometric sensing of glucose without the need for chromogenic substrates, cascade enzymatic reactions, or electrode systems. High sensitivity with a detection limit of 1.4 μmglucose was achieved, and the glucose levels in human sera were accurately determined. This strategy has led to a new application for MOFs that can be facilely extended to other MOF–enzyme composites due to the multifunctionality of MOFs.
Influence of the Insertion Method of Aryl‐Extended Calix[4]pyrroles into Liposomal Membranes on Their Properties as Anion Carriers
Authors: Martínez‐Crespo Luis , Sun‐Wang Jia Liang , Ferreira Pedro , Mirabella Chiara F. M. , Aragay Gemma , Ballester Pablo 
Published: February 2019

AbstractWe disclose the results of our investigations on the influence that the insertion method of aryl‐extended calix[4]pyrrole into liposomal membranes exerts on their properties as anion carriers. We use the standard HPTS assay to assess the transport properties of the carriers. We show that the post‐insertion of the carrier, as DMSO solution, assigns better transport activities to the “two‐wall” α,α‐aryl‐extended calix[4]pyrrole 1 compared to the “four‐wall” α,α,α,α‐counterpart 2. Notably, opposite results were obtained when the carriers were pre‐inserted into the liposomal membranes. We assign this difference to an improved incorporation of carrier 2 into the membrane when delivered by the pre‐insertion method. On the other hand, carrier 1 shows comparable levels of transport independently of the method used for its incorporation. Thus, an accurate comparison of the chloride transport activities featured by these two carriers demands their pre‐incorporation in the liposomal membranes. In contrast, using the lucigenin assay with the pre‐insertion method both carriers displayed similar transport efficiencies.
Pseudo‐One‐Coordinate Tetrylenium Salts Bearing a Bulky Carbazolyl Substituent
Authors: Hinz Alexander 
Published: February 2019

AbstractSyntheses of a bulky carbazole‐based substituent, the parent 1,8‐bis(3,5‐di‐tert‐butylphenyl)‐3,6‐di‐tert‐butyl‐carbazole (R−H) and a series of chlorotetrylenes, RECl (E=Ge, Sn, Pb), are described. Detailed analysis of the properties of the carbazole‐based substituent revealed that it features flexible high bulkiness and electronic non‐innocence, which may make it suitable for many applications in both main‐group and transition‐metal chemistry. To further showcase the employability of the novel substituent, the chlorotetrylenes were subjected to halide abstraction reactions, affording the corresponding tetrylenium salts [RE][Al(OC4F9)4] (E=Ge, Sn, Pb) as strongly coloured compounds.
Interplay Between Steric and Electronic Effects: A Joint Spectroscopy and Computational Study of Nonheme Iron(IV)‐Oxo Complexes
Authors: Mukherjee Gourab , Alili Aligulu , Barman Prasenjit , Kumar Devesh , Sastri Chivukula V. , de Visser Sam P. 
Published: February 2019

AbstractIron is an essential element in nonheme enzymes that plays a crucial role in many vital oxidative transformations and metabolic reactions in the human body. Many of those reactions are regio‐ and stereospecific and it is believed that the selectivity is guided by second‐coordination sphere effects in the protein. Here, results are shown of a few engineered biomimetic ligand frameworks based on the N4Py (N,N‐bis(2‐pyridylmethyl)‐N‐bis(2‐pyridyl)methylamine) scaffold and the second‐coordination sphere effects are studied. For the first time, selective substitutions in the ligand framework have been shown to tune the catalytic properties of the iron(IV)‐oxo complexes by regulating the steric and electronic factors. In particular, a better positioning of the oxidant and substrate in the rate‐determining transition state lowers the reaction barriers. Therefore, an optimum balance between steric and electronic factors mediates the ideal positioning of oxidant and substrate in the rate‐determining transition state that affects the reactivity of high‐valent reaction intermediates.
First Dual Responsive “Turn‐On” and “Ratiometric” AIEgen Probe for Selective Detection of Hydrazine Both in Solution and the Vapour Phase
Authors: Purohit Deepak , Sharma Chandra P. , Raghuvanshi Ashutosh , Jain Ankita , Rawat Kundan S. , Gupta Neeraj M. , Singh Jagriti , Sachdev Monika , Goel Atul 
Published: February 2019

AbstractA new dual responsive “turn‐on” and “ratiometric” aggregation‐induced emission luminogen (AIEgen) 3‐formyl‐5‐(piperidin‐1‐yl)biphenyl‐4‐carbonitrile 6 a (FPBC 6 a) for selective detection of hydrazine in solution as well as in vapour phase is described. At a low concentration of 2.5 μm, the probe FPBC 6 a is non‐fluorescent (turn‐off) but remarkably lights up (turn‐on with blue emission) in the presence of hydrazine solution (0.25–25 μm). Interestingly, at higher concentrations, the nanoaggregates of FPBC 6 a (>25 μm, 99 % HEPES in DMSO) displayed ratiometric response in the presence of hydrazine with a remarkable hypsochromic shift from the green (500–550 nm) to blue regions (440–480 nm). Furthermore, a real application of FPBC 6 a was successfully demonstrated through the detection and visualization of hydrazine in live cervical cancer cells as well as using portable test strips.
Tether‐Directed Regioselective Synthesis of an Equatorialface Bisadduct of Azafullerene Using Cyclo‐[2]‐octylmalonate
Authors: Stergiou Anastasios , Asad Karam , Kourtellaris Andreas , Chronakis Nikos , Tagmatarchis Nikos 
Published: February 2019

AbstractBisazafullerene (C59N)2 has been functionalized under aerobic conditions with cyclo‐[2]‐octylmalonate through a Mannich‐type reaction, furnishing the corresponding monoadduct. A regioselective tether‐directed Bingel cyclopropanation reaction was then carried out on the azafullerene core to yield a single bisadduct. Spectroscopic analysis of the formed bisadduct showed it to have a C1 symmetrical structure, making it inherently chiral. Single‐crystal X‐ray analysis revealed the addition pattern of the azafullerene bisadduct to be equatorialface. Examination of the optical properties showed the evolution of new absorption bands, which can be used as signatures for the characterization of equatorialface bisadducts of C59N. Finally, redox assays showed that the LUMO level of the equatorialface bisadduct was increased compared to that of the parent (C59N)2.
Lead‐Free Metal Halide Perovskite Nanocrystals: Challenges, Applications, and Future Aspects
Authors: Ghosh S. , Pradhan B. 
Published: February 2019

AbstractLead halide perovskite materials have shown strong promise in energy harvesting and generation over the past five years. However, their poor ambient stability and lead toxicity issues hinder optoelectronic applications. In the quest for alternatives, metal halide perovskites with lower toxicity and more stable metals have recently emerged. The divalent Pb2+ could be replaced with isoelectronic Sn2+, but Sn2+ tends to oxidize rapidly in presence of air to Sn4+, forming a defect in the structure. However, Sn2+‐based perovskites have been stabilized in 2D structures. Recently Sn4+ based halide perovskites nanocrystals with have been reported with poor luminescence. The replacement of Pb2+ with isoelectronic trivalent elements (Sb3+, Bi3+) results in A3B2X9 type defect‐order perovskite structure, which shows promises for optoelectronic applications. The perovskite nanocrystals of Sb, Bi have been reported in the form of dimers and layered structures. In addition to these, double perovskites, where two divalent Pb2+ are replaced with a monovalent and a trivalent cation have been reported very recently. In this Focus Review, we give a brief summary of different non‐lead perovskite nanocrystals starting from synthesis, characterization, stability, properties to applications, along with potential future directions.
Efficient Passivation of Ag Nanowires with 11‐Mercaptoundecanoic Acid Probed Using In Situ Total‐Internal‐Reflection Surface‐Enhanced Raman Scattering Spectroscopy
Authors: Plissonneau Marie , Madeira Alexandra , Talaga David , Bonhommeau Sébastien , Servant Laurent , Vallée Renaud A. L. , Labrugère Christine , Goldthorpe Irene A. , Pautrot‐D'Alencon Lauriane , Le Mercier Thierry , Treguer‐Delapierre Mona 
Published: February 2019

AbstractA promising passivation strategy of one class of Ag nanostructures of high interest for optoelectronics, namely Ag nanowires (AgNWs), with 11‐mercaptoundecanoic acid (MUA) is described. Combining XPS, electron microscopy and original in‐situ total‐internal‐reflection (TIR) surface‐enhanced Raman scattering (SERS) spectroscopic measurements, the substitution of polyvinylpyrrolidone (PVP) molecules on as‐synthesized PVP‐coated AgNWs by their MUA counterparts is clearly demonstrated. The relevance of the SERS approach to examine the anchoring of the MUA onto the silver surface of specific AgNWs with pentagonal cross‐sections is supported by FDTD simulations. In particular, the TIR‐SERS technique reveals that the PVP‐MUA substitution process can be divided into two main steps, namely (i) the desorption of PVP molecules associated with the anchoring of MUA molecules via the formation of Ag−OOC and Ag−S bonds (accomplished within 40 min), and (ii) the subsequent reorientation of MUA molecules to form only Ag−S bonds (finished in 90 min). The resulting passivation of AgNWs with MUA significantly improves their resistance to corrosion, which is crucial for future commercial applications.
Randomized Phase I Trial to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Topical Daprodustat in Healthy Volunteers and in Patients With Diabetic Foot Ulcers
Authors: Olson Eric , Mahar Kelly M. , Morgan Lisa , Fillmore Christina , Holland Claire , Lavery Lawrence 
Published: February 2019

AbstractDaprodustat, a small‐molecule inhibitor of prolyl hydroxylases, prevents breakdown of hypoxia‐inducible factor (HIF), leading to increased transcription of HIF‐responsive genes. This randomized, placebo‐controlled study evaluated the safety, tolerability, and pharmacokinetics of a topical formulation of daprodustat in healthy volunteers (intact skin) and in patients with diabetic foot ulcers (DFUs) following single and/or 14‐day repeat‐dose administration. In the diabetic patients, exploratory assessments of wound area, volume, and depth were made to qualitatively assess effectiveness. Systemic absorption via topical application was limited across doses up to 1.0% at 100 mg/cm2 for 14 days. Systemic pharmacokinetics were quantifiable in a few samples from a few patients. Because only sporadic concentrations were observed versus pharmacokinetic profiles, pharmacokinetic parameters were not determined. Wound area, depth, and volume showed consistent but weak improvements in the treatment arm; however, the variability in response and small sample size of the standard‐of‐care and placebo arms limited the ability to assess trends in wound healing compared with the daprodustat arm. Overall, topically applied daprodustat was well tolerated, raised no safety concerns, and provided limited to nonquantifiable systemic exposures. The healing of DFUs will need to be evaluated in studies designed to test this hypothesis over a longer treatment duration.
Retracted: The mechanism and experimental study on the interference of high voltage lines to navigation system
Authors: Fan Linjing , Pan Xuchao , Huang Zhengxiang , Zu Xudong 
Published: February 2019

AbstractRetraction: Linjing Fan Xuchao Pan Zhengxiang Huang Xudong Zu., The mechanism and experimental study on the interference of high voltage lines to navigation system. Concurrency and Computation: Practice and Experience. 2019;e4718, https://doi.org/10.1002/cpe.4718. The above article, published online on 4th February 2019 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the authors, the Editor, Professor Geoffrey Fox, and John Wiley and Sons Ltd. The retraction has been agreed due to inadequacies in the theoretical simulation resulting in foundational errors that are cannot be addressed through an erratum.