bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Impact of Ethnicity on Craniosynostosis in the United States
Authors: Sacks Gina N. , Skolnick Gary B. , Trachtenberg Ali , Naidoo Sybill D. , Lopez Joseph , Oh Albert K. , Chao Jerry W. , Dorafshar Amir , Vercler Christian J. , Buchman Steven R. , Patel Kamlesh 
Published: October 2019

Abstract
While many studies have examined potential risk factors for nonsyndromic craniosynostosis, there have been no publications to date investigating the role of ethnicity in the United States. The current study was undertaken as the first multi-center investigation to examine the relationship between ethnicity and nonsyndromic craniosynostosis, looking at both overall prevalence as well as potential correlation between ethnicity and pattern of affected suture site. A chart review of patients diagnosed with nonsyndromic craniosynostosis treated at four major children's hospitals was performed to obtain ethnicity data. Analysis was preformed based on ethnic group as well as suture site affected. To account for potential
One regional selection bias, the KID database (1997–2012) was utilized to identify all cases of craniosynostosis on a national level. This data was analyzed against birth rates by ethnicity obtained from CDC WONDER natality database.
Amongst the 2112 cases of nonsyndromic craniosynostosis at all institutions, Caucasians and African Americans were consistently the predominant ethnic groups. There was a statistically significant difference in the distribution of affected suture type with African Americans more likely to present with unicoronal synostosis and Caucasians more likely to present with metopic synostosis (P = 0.005). The national data revealed that there were more cases of craniosynostosis in Caucasians and fewer in African Americans than expected when compared to population birth rates. Our findings demonstrate that the Caucasian race is associated with increased rates of synostosis.
Posttransplant Calcineurin Inhibitors Levels and Intrapatient Variability Are Not Associated With Long-term Outcomes Following Liver Transplantation
Authors: Di Maira Tommaso , Sapisochin Gonzalo , Lilly Les , Fonés Victoria , Berenguer Marina 
Published: October 2019

Background.
There is an interest in understanding the association between early calcineurin inhibitors exposure post-liver transplantation (LT) and long-term outcomes. We aimed to analyze this association exploring median calcineurin inhibitor levels and intrapatient variability (IPV) in a multicenter, retrospective cohort.

Methods.
Tacrolimus (Tac) and Cyclosporine (CsA) levels obtained during the first 15 days post-LT were collected. High immunosuppression (IS) was considered as a median of Tac, CsA blood trough levels 12 hours after drug administration, or blood levels 2 hours after drug administration higher than 10, 250, or 1200 ng/mL, respectively, or a peak of Tac >20 ng/mL. Optimal IS was defined as a median of Tac, CsA blood trough levels 12 hours after drug administration, or blood levels 2 hours after drug administration levels between 7 and 10, 150 and 250, or 800 and 1200 ng/mL. Low IS was defined as below the thresholds of optimal IS. IPV was estimated during the first 15 days post-LT.

Results.
The study included 432 patients with a median follow-up of 8.65 years. IS regimen was based on either Tac or CsA in 243 (56.3%) and 189 (43.8%), respectively. There were no differences in terms of graft loss among low versus optimal and high IS groups (P = 0.812 and P = 0.451) nor in high versus low IPV (P = 0.835). Only viral hepatitis and arterial hypertension were independently associated with higher graft loss (hazard ratio = 1.729, P = 0.029 and hazard ratio = 1.570, P = 0.021).

Conclusions.
In contrast to what has previously been reported, no association was found between very early postoperative over IS or high IPV and long-term outcome measures following LT. Strategies aimed at reducing these long-term events should likely focus on other factors or on a different IS time window.
Tumor treating fields for glioblastoma: should it or will it ever be adopted?
Authors: Thomas Alissa A. , Rauschkolb Paula K. 
Published: October 2019

Purpose of review
The purpose of this review is to discuss how a new treatment modality, tumor treating fields, may be incorporated into the oncologic care for patients with glioblastoma.

Recent findings
Tumor treating fields are a new treatment modality available to patients with newly diagnosed and recurrent glioblastoma. Alternating electric fields are delivered via a wearable, removable device affixed to the scalp of patients with supratentorial glioblastoma. With continuous use, the application of tumor treating fields combined with temozolomide chemotherapy has been shown to improve overall survival compared with temozolomide alone in patients with newly diagnosed glioblastoma. Adverse events attributable to the device are limited to localized skin reactions. Despite compendium guidelines in support of its use and Food and Drug Administration (FDA) approval, tumor treating fields have been slow to be adopted in the neuro-oncology community. Critics have raised concerns about the generalizability of the study data, patient quality of life, and mechanism of action of this therapy.

Summary
Tumor treating fields are available for the treatment of both newly diagnosed and recurrent glioblastoma and represent a new category of treatment modalities in oncologic therapy. This novel device has received FDA approval but has been slow to be adopted into clinical practice.
Enhanced Depth Imaging Optical Coherence Tomography of Optic Nerve Head Drusen in Children
Authors: Sim Peng Yong , Soomro Hibba , Karampelas Michael , Barampouti Faye 
Published: October 2019

Background:
To assess the utility of enhanced depth imaging optical coherence tomography (EDI-OCT), compared with other conventional imaging modalities, for detecting and characterizing optic nerve head drusen (ONHD) in children.

Methods:
We report a retrospective cross-sectional case series of consecutive pediatric patients (age ≤16 years) with ONHD confirmed using B-scan ultrasonography. All eyes were evaluated using spectral-domain OCT of the optic nerve head in conventional (non-EDI) and EDI modes, fundus autofluorescence (FAF), and standard automated perimetry. Detection rates and the capacity to characterize ONHD were compared between EDI-OCT, non–EDI-OCT, and FAF.

Results:
Twenty-eight eyes of 15 patients (mean age 11 years; 60% female) were identified with definite ONHD that were confirmed by B-scan ultrasound. Among the technologies, EDI-OCT, non–EDI-OCT, FAF, and automated perimetry had findings consistent with ONHD in 24, 21, 18, and 4 eyes, respectively. EDI-OCT had a significantly better detection capability (86% of eyes) compared with FAF (P = 0.04) but not with non–EDI-OCT (P = 0.15). Similar to results previously reported in adult patients, EDI-OCT detected ONHD at different levels of depth; most were located anterior to the lamina cribrosa. ONHD detected by EDI-OCT appeared as hypo‐reflective ovoid regions bordered by hyper-reflective material or as isolated hyper-reflective bands without a hypo-reflective core. The mean greatest diameter of ONHD seen on EDI-OCT was 449.7 (SD ±114.1) μm.

Conclusions:
EDI-OCT detects ONHD in most eyes identified as having drusen on B-scan ultrasonography. This technique has the potential to be an effective alternative first-line diagnostic and monitoring tool for ONHD, particularly for detecting buried drusen in children.
Bioinspired aerofoil adaptations: the next steps for theoretical models
Authors: Ayton Lorna J. 
Published: October 2019

The extended introduction in this paper reviews the theoretical modelling of leading- and trailing-edge noise, various bioinspired aerofoil adaptations to both the leading and trailing edges of blades, and how these adaptations aid in the reduction of aerofoil–turbulence interaction noise. Attention is given to the agreement between current theoretical predictions and experimental measurements, in particular, for turbulent interactions at the trailing edge of an aerofoil. Where there is a poor agreement between theoretical models and experimental data the features neglected from the theoretical models are discussed. Notably, it is known that theoretical predictions for porous trailing-edge adaptations do not agree well with experimental measurements. Previous works propose the reason for this: theoretical models do not account for surface roughness due to the porous material and thus omit a key noise source. The remainder of this paper, therefore, presents an analytical model, based upon the acoustic analogy, to predict the far-field noise due to a rough surface at the trailing edge of an aerofoil. Unlike previous roughness noise models which focus on roughness over an infinite wall, the model presented here includes diffraction by a sharp edge. The new results are seen to be in better agreement with experimental data than previous models which neglect diffraction by an edge. This new model could then be used to improve theoretical predictions for far-field noise generated by turbulent interactions with a (rough) porous trailing edge.
This article is part of the theme issue ‘Frontiers of aeroacoustics research: theory, computation and experiment’.
Sound from aeroelastic vortex–fibre interactions
Authors: Jaworski J. W. 
Published: October 2019

The motion of a line vortex moving past a one-dimensional flexible fibre is examined theoretically. A Schwarz–Christoffel conformal mapping enables the analytical solution of the potential flow field and its hydrodynamic moment on the flexible fibre, which is composed of a rigid segment constrained to angular motions on a wedge. The hydroelastic coupling of the vortex path and fibre motion affects the noise signature, which is evaluated for the special case of acoustically compact fibres embedded in a half plane. Results from this analysis attempt to address how the coupled interactions between vortical sources and flexible barbules on the upper surface of owl wings may contribute to their acoustic stealth. The analytical formulation is also amenable to application to vortex sound prediction from flexible trailing edges provided that an appropriate acoustic Green's function can be determined.
This article is part of the theme issue ‘Frontiers of aeroacoustics research: theory, computation and experiment’.
SALTClass: classifying clinical short notes using background knowledge from unlabeled data
Authors: Bagheri Ayoub , Oberski Daniel , Sammani Arjan , van der Heijden Peter G.M. , Asselbergs Folkert W. 
Published: October 2019

AbstractBackgroundWith the increasing use of unstructured text in electronic health records, extracting useful related information has become a necessity. Text classification can be applied to extract patients’ medical history from clinical notes. However, the sparsity in clinical short notes, that is, excessively small word counts in the text, can lead to large classification errors. Previous studies demonstrated that natural language processing (NLP) can be useful in the text classification of clinical outcomes. We propose incorporating the knowledge from unlabeled data, as this may alleviate the problem of short noisy sparse text.ResultsThe software package SALTClass (short and long text classifier) is a machine learning NLP toolkit. It uses seven clustering algorithms, namely, latent Dirichlet allocation, K-Means, MiniBatchK-Means, BIRCH, MeanShift, DBScan, and GMM. Smoothing methods are applied to the resulting cluster information to enrich the representation of sparse text. For the subsequent prediction step, SALTClass can be used on either the original document-term matrix or in an enrichment pipeline. To this end, ten different supervised classifiers have also been integrated into SALTClass. We demonstrate the effectiveness of the SALTClass NLP toolkit in the identification of patients’ family history in a Dutch clinical cardiovascular text corpus from University Medical Center Utrecht, the Netherlands.ConclusionsThe considerable amount of unstructured short text in healthcare applications, particularly in clinical cardiovascular notes, has created an urgent need for tools that can parse specific information from text reports. Using machine learning algorithms for enriching short text can improve the representation for further applications.AvailabilitySALTClass can be downloaded as a Python package from Python Package Index (PyPI) website athttps://pypi.org/project/saltclassand from GitHub athttps://github.com/bagheria/saltclass.
Highly efficient direct conversion of human monocytes into neuronal cells using a small molecule combination
Authors: Ninomiya Itaru , Kanazawa Masato , Koyama Akihide , Hatakeyama Masahiro , Onodera Osamu 
Published: October 2019

SummaryPrevious studies reported that human fibroblasts and astrocytes were successfully converted into neuronal cells by small molecules without introducing ectopic transgenes. Induced neuronal cells—reprogrammed directly from dermal fibroblasts or brain astrocytes—were obtained from some donors; however, the clinical applications of this approach would be limited because it requires an invasive biopsy to harvest enough cells for derivation. Here, we report that adult human peripheral blood monocytes may be directly converted into neuron-like cells using only a combination of small molecules without transgene integration. This method enables neuronal cell generation from TUJ1-positive cells after 3 days of induction (at over 80% conversion efficacy). These cells presented neuronal morphologies and markers, suggesting that terminally differentiated human cells may be efficiently transdifferentiated into a distantly related lineage. Overall, our study provides a strategy to develop neuronal cells directly from human adult peripheral blood monocytes using a generate transgene-free, chemical-only approach.
Deconstructing the structural conservation of distantly related bacterial nucleoid-associated proteins using functional chimeras
Authors: Lourenço Rogério F. , Saurabh Saumya , Herrmann Jonathan , Wakatsuki Soichi , Shapiro Lucy 
Published: October 2019

ABSTRACTNucleoid-associated proteins (NAPs) are DNA-binding proteins critical for the organization and function of the bacterial chromosome. A subclass of NAPs, includingCaulobacter crescentusGapR andEscherichia coliH-NS, preferentially bind AT-rich regions of the nucleoid, but phylogenetic groups that encode GapR rarely encode H-NS. Here, utilizing genetic, biochemical, and biophysical studies of GapR in light of a recent DNA-bound crystal structure of GapR (Guo et al, 2018), we show that although evolutionarily distant, GapR and H-NS possess two regions that are structurally and functionally conserved. These regions are involved in self-association and DNA-binding, even though the two proteins oligomerize and regulate transcription differently. Functional analysis of GapR and H-NS protein chimeras identified structural elements present in H-NS but absent in GapR that rationalize differences in transcriptional regulation. In addition, we identified a sequence element unique to GapR that enables assembly into its tetrameric state. Using fluid-atomic force microscopy, we showed that GapR is capable of bridging DNA moleculesin vitro. Together, these results demonstrate that two distantly related NAPs utilize evolutionarily conserved structural elements to serve specialized cellular roles via distinct mechanisms.
Globalizing community festivals: the case of the community festival in Wanwei, Guangxi, China
Authors: Nguyen Cham 
Published: October 2019

Purpose
The purpose of this paper is to concern the community festival of a Jing minority village in the China–Vietnam border area. Since it was designated as a national-level Intangible Cultural Heritage in 2006, the festival has undergone many changes. The festival has steadily expanded and evolved, assuming characteristics of globalization. How is the globalized character of the Wanwei festival manifested? What are the forces behind the elevation of this local festival onto the register of national events and how did it turn into an event organized by the township?

Design/methodology/approach
The paper is based on the results of the author’s research on the culture of Kinh people in Wanwei from 2000 to the present. From the anthropological approach, the author mainly uses method of participant observation and in-depth interviews. The author has observed the Wanwei communal festival from 2000 to the present, interviewing about 40 villagers in Wanwei in depth, they can be leaders, intellectuals, civil servants, officials or working people.

Findings
The paper is a case study of the new aspect of globalization of a village festival. The author argues that globalization can lead to a spread of global flows but in this process of globalization, villagers also want to define the local identity, they reinvent the tradition, rewrite history, create new nuances for the gods with many different purposes. Practicing the current Wanwei village festival is a vivid example of globalization from below and the politics of tradition.

Originality/value
The paper adds a theoretical dimension to current globalization research. The paper also points out the political, economic and social dynamics that govern the transformation of a village festival in particular and the village culture in general in the border areas. The paper is a testament to the dynamism and flexibility of villagers when participating in the current globalization process.
Analyzing the impact of corporate social responsibility on corporate financial performance: evidence from top Indian firms
Authors: Sekhon Amritjot Kaur , Kathuria Lalit Mohan 
Published: October 2019

PurposeDespite continuous research efforts, the literature is still inconclusive about the relationship between corporate social responsibility (CSR) and financial performance. With an aim to address this problem, this study aims to analyze the impact of CSR on financial performance in the Indian context.Design/methodology/approachUsing a panel of top 137 companies from CNX-500 for 10 years (2008-2017), the impact of CSR on three indicators of financial performance, namely, Return on Assets (ROA), Return on Equity (ROE) and Net Profit Margin (NPM), is evaluated using the panel data regression analysis. The technique of content analysis is used to collect data on CSR from the annual reports of selected companies.FindingsThe study finds that the impact of CSR on financial performance may be neutral (with ROA and NPM) or negative (with ROE). The negative influence of CSR on ROE of firms supports the theory by Friedman (1970) that the only responsibility of business is to maximize profits and returns for its shareholders.Originality/valueAfter amendments in Companies Act, 2013, there is limited literature addressing this scientific inquiry in the Indian context. The study period (2008-2017) includes CSR disclosures from both periods, before reforms and after reforms, which adds to the uniqueness of this research study. In addition, this study uses a research instrument consisting of a total of 178 CSR activities divided across 46 themes for collecting data from annual reports of the companies. The utilization of such a comprehensive research instrument, for the study, also adds to its peculiarity.
Assessing cross-national invariance of the three-component model of organizational commitment
Authors: Nandan Shefali , Halkias Daphne , Thurman Paul W. , Komodromos Marcos , Alserhan Baker Ahmad , Adendorff Chris , Yahaya Alhaj Norashfah Hanim Yaakop , De Massis Alfredo , Galanaki Eleanna , Juma Norma , Kwesiga Eileen , Nkamnebe Anayo D. , Seaman Claire 
Published: October 2019

PurposeThe purpose of this paper is to examine affective commitment, normative commitment, and continuance commitment in a cross-national context to identify if the effect of country-specific cultural orientation on organizational commitment of faculty in higher education functions invariably in different countries.Design/methodology/approachThe work expands on Meyer and Allen’s (1991) three-component model of organizational commitment. It includes relevant literature review on ten countries and the results of a survey of university faculty members, assessing their institutions’ human resources practices and their effect on organizational commitment. Basic descriptive statistics were performed on nominal and interval data, means, medians, and standard deviations were computed, and tests of mean equivalence, including ANOVA tests, were performed. In certain instances, Pearson and Spearman correlations were computed to ascertain correlation, andχ2tests for randomized response were used, while Cronbach’sαtest helped to establish survey instrument validity.FindingsThough certain differences may exist between different countries and cultures with respect to the three-component model of organizational commitment, there is strong evidence of the existence of invariance and, thus, generalizability of the model across cultures.Research limitations/implicationsCultural studies have focused on differences in organizational commitment at national levels. Further attempts to identify the universality of factors leading to organizational commitment should account for culture in the study of employee-related globalization issues in higher education institutes. Knowledge of cultural impact is also useful from a managerial perspective, and for the design of relevant strategies.Practical implicationsNational context plays a major role in shaping the nature of educational institutions. This study brings out the need for a deeper understanding of invariance in organizational commitment (inter-alia, through the three-component model).Originality/valueThis study contributes to a better understanding of the relationship between organizational commitment and its various antecedents, including human resources management practices, for faculty in higher education institutes.