bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficacy and safety of weekly liquid alendronate in Korean postmenopausal women with osteoporosis: a 12-month, multi-center, randomized trial
Authors: Baek Seungjin , Ahn Seong Hee , Hong Namki , Seo Da Hea , Hong Seongbin , Rhee Yumie 
Published: November 2024

Abstract

Summary

This study compared liquid and tablet forms of alendronate for osteoporosis treatment. After 12 months, both forms increased bone density to a similar degree with no significant differences in side effects. New low-volume liquid alendronate is as effective as tablets, offering an alternative treatment option for postmenopausal women with osteoporosis.

Purpose/Introduction
Alendronate, despite its significant efficacy, poses challenges due to complex administration protocols and patient compliance issues, underscoring the need for various formulations. This study compared the efficacy and safety of once-weekly low-volume liquid alendronate sodium trihydrate (ALN-S), an oral solution, to once-weekly alendronate sodium (ALN-T), an oral tablet, in Korean postmenopausal women with osteoporosis.

Methods
In a 12-month, multi-center, prospective, randomized, open-labeled, parallel trial conducted at two hospitals in Korea, 170 patients were randomized to alendronate solution (ALN-S) (N = 85) or alendronate tablet (ALN-T) (N = 85) groups. The bone mineral density (BMD) of the lumbar spine (LS), femoral neck (FN), and total hip (TH) was measured at baseline and after 12 months. Bone turnover markers (BTMs) were assessed at baseline, 6, and 12 months. The primary outcome was the percentage change in BMD of the LS, evaluated for non-inferiority.

Results
After 12 months, both ALN-S and ALN-T groups exhibited a significant increase in LS, FN, and TH BMD, with no significant intergroup differences (ALN-S: LS 5.0 ± 0.6%, FN 1.8 ± 0.6%, TH 2.2 ± 0.5%; ALN-T: LS 5.2 ± 0.6%, FN 1.6 ± 0.6%, TH 1.8 ± 0.5%). ALN-S was found to be non-inferior to ALN-T for BMD change at LS (treatment difference: − 0.22%, 95% CI: − 1.84 to 1.40%), excluding the predefined non-inferiority margin of − 2.29%. Changes in BTMs did not differ significantly between groups. The frequency of adverse events was similar between groups.

Conclusion
Liquid alendronate was non-inferior to tablet alendronate in increasing BMD in Korean postmenopausal women with osteoporosis, presenting a viable alternative when the tablet form is limited in various clinical scenarios.

Clinical trial registration
The trial was registered with ClinicalTrials.gov (NCT05387200).
Microstructure Development in Duplex Stainless Steels from Additive Manufacturing with Coaxial Directed Energy Deposition and Heat Treatment
Authors: Hassel Trond Arne , Marken Lene Anita , Arbo Siri Marthe , Rørvik Gisle , Du Qiang , Brøtan Vegard , Sørby Knut 
Published: November 2024

Abstract
Duplex stainless steels are widely used in offshore oil and gas, maritime, process, and nuclear industries as they deliver high corrosion resistance, toughness, and ductility, but they are sensitive to formation of brittle microstructures during additive manufacturing. This study has explored the microstructural development during heat treatment for three duplex stainless steel grades: 2205, 2209, and 2509, built by wire-fed coaxial directed energy deposition. The as-built and heat-treated microstructures (solution annealed at $$1020 \, {\text{to}}\,1170~^{\circ }$$

1020

to

1170

∘

C) have been studied and compared. The 2209 and 2509 grades produced more homogeneous microstructures with higher austenite fractions in the as-built condition than 2205. To avoid sigma phase precipitation, 2209 and 2509 had to be solution annealed at higher temperatures than conventional duplex and super duplex. The experimental findings were compared with volume fraction estimates from thermodynamic calculations. For 2209, both as-built and heat-treated materials were evaluated through hardness and Charpy impact toughness testing, revealing significantly improved toughness after heat treatment. Optimal heat treatments produced limited grain growth and fine-grained slightly spheroidized Widmanstätten austenite morphology without any detrimental phases. The presented results offer valuable insights for optimizing microstructure through heat treatment of additively manufactured duplex stainless steel.
Additive-Manufacturing-Induced Cell Structure in Stainless Steel 316L: 3D Morphology and Formation Mechanism
Authors: Wang Xiaobo , Nadimpalli Venkata Karthik , Tiedje Niels Skat , Juul Jensen Dorte , Yu Tianbo 
Published: November 2024

AbstractThe 3D morphology of the additive-manufacturing-induced cell structure is characterized and its formation in austenitic stainless steel 316L fabricated by laser powder bed fusion is analyzed. The experimental results demonstrate that the cell structure has a 3D prism-like morphology with a crystallography-dependent spatial orientation. The formation of the cell structure is discussed. It is proposed that both the liquid–solid transformation and thermal strain contribute to the formation: the initial cells form during the liquid–solid transformation, and the final dislocation cell structure is shaped by thermal-stress-induced deformation during cooling and subsequent thermal cycles.
Applying the Principles of Trauma-Informed Care to the Evaluation and Management of Patients Who Undergo Metabolic and Bariatric Surgery
Authors: Sarwer David B. , Schroeder Krista , Fischbach Sarah R. , Atwood Sophia M. , Heinberg Leslie J. 
Published: November 2024

AbstractEvaluation of relevant psychosocial variables is an important aspect of comprehensive, high-quality metabolic and bariatric surgery (MBS) care. Given the high rates of adverse childhood experience (ACEs) and other forms of trauma experienced later in life reported by individuals with class III obesity, it is time to apply the principles of trauma-informed care to the multidisciplinary care of MBS patients. This narrative review begins with a summary of the literature on the psychosocial functioning of individuals who present for MBS. Emphasis is placed upon the relationship between ACEs, class III obesity, and MBS. Trauma-informed care is defined, and its principles are applied to the MBS care continuum. The paper ends with a recommendation on how the field of MBS can integrate trauma-informed care into clinical practice and future research.
Family Forest Landowners’ Preferences for Meeting Format and Outreach with Forest Professionals Post-COVID-19
Authors: Penn Jerrod , Gutierrez-Castillo Ana , Blazier Michael 
Published: November 2024

AbstractOutreach to family forest landowners promotes sustainable forest management activities but shifting demographics may challenge the usefulness of conventional outreach approaches. COVID-19 also changed communication patterns, with unprecedented adoption of video conferencing (e.g., Zoom), creating a potential alternative for forestry professionals. We surveyed Arkansas and Louisiana family forest landowners using online and mail response options to understand their preferred meeting mode for participating in forestry outreach, ranging from in-person to online meetings, as well as their prior forest information sources and topics. Our findings show that over a third of landowners increased the use of video calls during COVID-19 and that two-thirds of landowners either prefer online meetings or are indifferent between online versus in-person meetings. Factors conducive of “in-person or online” and “online only” meetings include distance to forestland, increased video calling and past e-mail and social media use frequency, online survey response, individual ownership, past reforestation, and recreation objective. Online survey respondents represent a demographically different segment of forest landowners. Online methods will become increasingly attractive as a new generation of landowners takes over for forest management who have greater familiarity and use of online communication methods.
Detection of production relevant deviations in paint sprays
Authors: Tiedje Oliver , Paustian Stephan , Rosenkranz Simon , Hecker Meiko , Tropea Cameron 
Published: November 2024

AbstractSpray painting is still a poorly manageable process due to the complex interaction of physical, chemical and environmental influences like turbulent air flows, strong electrostatic fields, complex viscosity of paints and paint booth conditions. Consequently, many important properties of the painted film, like thickness, color, surface structure and the efficiency of the process are not controllable in an adequate manner, despite the enormous economic ramifications of poor quality control in high volume applications, such as in the automotive industry. This study shows how novel, online spray monitoring can instantaneously generate characterizing quantities from the spray to detect harmful deviations in the process. In this study, several minute changes have been experimentally imposed on a paint system, such as changed paint viscosity or pigmentation, deviations in air flow and paint flow rates, and defective or used and worn equipment parts. It will be shown that all these deviations lead to features which allow a clear distinction from the intact and reference cases. Additionally, it is shown that most of the deviations, if not detected, would have led to quality issues of the paint coating.
Need satisfaction matters: The role of need satisfaction at work in work-related rumination
Authors: Manuoglu Elif , Dalgar Ilker , Máčalová Vendula , Šmilňák Richard 
Published: November 2024

AbstractThe aim of this study is twofold. First, it evaluates the psychometric properties of the Czech adaptation of the Work-Related Rumination Questionnaire (WRRQ) and Basic Psychological Need Satisfaction and Frustration Scale-Work Domain (BPNSFS-W). Second, the link between work-related rumination and work-related need satisfaction was examined. Three forms of work-related rumination, namely, affective rumination, pondering, and detachment were hypothesized to have distinct associations with the satisfaction of autonomy, competence, and relatedness needs at work. There were 278 employees (67% female, Mage= 40.22, SD = 12.98) completing an online survey. CFA confirmed the three-factor model of both WRRQ and BPNSFS-W. Moreover, the measurement invariance of both scales was investigated across gender. The BPNSFS-W has measurement invariance, and WRRQ has partial measurement invariance across females and males. Hierarchical regression analyses showed that while competence did not predict any form of WRR, relatedness positively predicted detachment. Moreover, autonomy positively predicted pondering and negatively predicted affective rumination. Findings suggest that the WRRQ and BPNSFS-W are promising instruments for future research and practice in the Czech context.
Locoregional therapy of oligometastatic breast cancer
Authors: Fitzal Florian 
Published: November 2024

Summary
Oligometastastic disease has been defined as not more than five metastases found in radiological workup within not more than two different distant organs of the body [1]. Starting in 1995, several authors claimed that local treatment, especially radiotherapy, may have a positive impact on oligometastatic patients. However, prospective trials demonstrated that local therapy of nonsymptomatic metastases should not be routinely offered as there is no survival benefit. Surgical resection of primary breast cancer in synchronous stage IV disease should also not be offered. However, there is a window of opportunity for men and women with synchronous oligometastatic disease where a true R0 resection by treating metastases as well as the primary cancer may be achieved. These cases need to be discussed within a multidisciplinary team (MDT) conference and should be included in new trials.
A domain adaptation technique through cluster boundary integration
Authors: Devagiri Vishnu Manasa , Boeva Veselka , Abghari Shahrooz 
Published: November 2024

AbstractMany machine learning models deployed on smart or edge devices experience a phase where there is a drop in their performance due to the arrival of data from new domains. This paper proposes a novel unsupervised domain adaptation algorithm called DIBCA++ to deal with such situations. The algorithm uses only the clusters’ mean, standard deviation, and size, which makes the proposed algorithm modest in terms of the required storage and computation. The study also presents the explainability aspect of the algorithm. DIBCA++ is compared with its predecessor, DIBCA, and its applicability and performance are studied and evaluated in two real-world scenarios. One is coping with the Global Navigation Satellite System activation problem from the smart logistics domain, while the other identifies different activities a person performs and deals with a human activity recognition task. Both scenarios involve time series data phenomena, i.e., DIBCA++ also contributes towards addressing the current gap regarding domain adaptation solutions for time series data. Based on the experimental results, DIBCA++ has improved performance compared to DIBCA. The DIBCA++ has performed better in all human activity recognition task experiments and 82.5% of experimental scenarios on the smart logistics use case. The results also showcase the need and benefit of personalizing the models using DIBCA++, along with the ability to transfer new knowledge between domains, leading to improved performance. The adapted source and target models have performed better in 70% and 80% of cases in an experimental scenario conducted on smart logistics.
Event Classification on Subsea Pipeline Inspection Data Using an Ensemble of Deep Learning Classifiers
Authors: Dang Truong , Nguyen Tien Thanh , Liew Alan Wee-Chung , Elyan Eyad 
Published: November 2024

Abstract
Subsea pipelines are the backbone of the modern oil and gas industry, transporting a total of 28% of global oil production. Due to several factors, such as corrosion or deformations, the pipelines might degrade over time, which might lead to serious economic and environmental damages if not addressed promptly. Therefore, it is crucial to detect any serious damage to subsea pipelines before they cause dangerous catastrophes. Inspections of subsea pipelines are usually made using a Remote Operating Vehicle and the inspection data is usually processed manually, which is subject to human errors, and requires experienced Remote Operating Vehicle operators. It is thus necessary to automate the inspection process to enable more efficiency as well as reduce costs. Besides, it is recognised that specific challenges of noisy and low-quality inspection data arising from the underwater environment prevent the industry from taking full advantage of the recent development in the Artificial Intelligence field to the problem of subsea pipeline inspection. In this paper, we developed an ensemble of deep learning classifiers to further improve the performance of single deep learning models in classifying anomalous events on the subsea pipeline inspection data. The output of the proposed ensemble was combined based on a weighted combining method. The weights of base classifiers were found by minimising the difference between the weighted combining result and the given associated ground truth annotation information. Three inspection datasets, gathered from different oil and gas companies in the United Kingdom, were analysed. These datasets were recorded under varying conditions and include a range of anomalies. The results showed that the proposed ensemble achieves around 78% accuracy on two datasets and more than 99% accuracy on one dataset, which is better compared to base classifiers and two popular ensembles.
The Role of Panendoscopy in Primary Diagnostics of Patients with Oral Cavity Cancer
Authors: Jordan Katherina , Ritschl Lucas , Fichter Andreas , Wolff Klaus Dietrich , Greber Lukas , Nieberler Markus 
Published: November 2024

Abstract
Purpose
Panendoscopy is known as a standard procedure in the staging of oral cavity cancer (OCC), which is intended to rule out synchronous second carcinomas (SSC) (Metzger K et al in J Craniomaxillofac Surg 47(12):1968–1972, 2019; Priante et al. in Curr Oncol Rep 13(2):132–137, 2011; Stoeckli et al. in Otolaryngol Head Neck Surg 124(2):208–212, 2001; Sharma et al in Laryngorhinootologie 92(3):166–169, 2013). However, the value in relation to the detection of SSC in the upper aerodigestive tract is questionable (Deutsche Gesellschaft für Mund- Kiefer- und Gesichtschirurgie (DGMKG), S3-Leitlinie Diagnostik und Therapie des Mundhöhlenkarzinoms. https://www.leitlinienprogramm-onkologie.de/leitlinien/mundhoehlenkarzinom/, 2021). The aim of the study was to redefine the role of panendoscopy in the staging of OCC—not only with regard to the detection of SSC—as the arrangement of panendoscopy is subject to further influencing factors. In addition, the diagnostic added value and effects on the therapy of the index tumor were elicited.

Material and methods
A retrospective review of 191 patients with a confirmed diagnosis of OCC was conducted, between January 2018 and December 2019, at the Department of Oral and Maxillofacial Surgery of the clinic of the Technical University of Munich, Germany. Panendoscopy included inspection and palpation of the oral cavity and oropharynx, epipharyngoscopy, microlaryngoscopy, and rigid esophagoscopy.

Results
The following parameters had a statistically significant influence on the decision to perform panendoscopy in primary diagnostics: risk factors, ENT status, and imaging. Panendoscopy was indicated in the primary diagnostics due to a suspicion of an SSC in 22.5% of patients and due to recurrence in 29%. The exact determination of localization and assessment of tumor extent was the decisive indicator for panendoscopy in 25.8% of patients. Of the 31 panendoscopies performed, a tissue sample was obtained in 67.7% (n = 21); none of the suspected cases proved to be an SSC.

Conclusion
Panendoscopy in the primary diagnostics of OCC should not be routinely indicated (Koerdt et al in Anticancer Res 41(4):2039–2044, 2021), but should be indicated on an as-needed basis, taking patient-specific criteria into account. In addition to ENT status and imaging, the risk factors of smoking and alcohol should be considered. In patients with unremarkable mirror and radiological findings and no risk factors, panendoscopy can be omitted without further risk (Metzger K et al in J Craniomaxillofac Surg 47(12):1968–1972, 2019; Koerdt et al in Anticancer Res 41(4):2039–2044, 2021).
Riverine Cu-distribution in sediments of the Jaba-Kawerong river system 30 years after cease of mining at Panguna/Bougainville
Authors: Sindern Sven , Küpper Nina , Müller Axel , Knisch Irina , Adolffs Tim , Stanjek Helge , Thüns Nicolai 
Published: November 2024

AbstractThe investigation of surface and river sediments over 30 years after the cease of large scale Cu and Au mining operation at Panguna (Bougainville) shows the impact of mining and tailings disposal on the associated riverine environment. While Zn, Pb and Cd have elevated concentrations in the former mining area and are low (< 100, < 28, < 1 mg/kg, respectively) in sediment of the Jaba-Kawerong river system, Cu represents the dominant environmental metal emission. Sediments of active streams and overbank deposits range between 1000 and 3000 mg/kg Cu. Most samples exceed freshwater sediment or soil quality guideline values, indicating the probability of toxic effects on sediment dwelling or aquatic organisms and ecological or health risks associated to agricultural use of the former mining area and floodplains. Copper in surface and river sediments is associated to bornite, chalcopyrite and chloritized biotite of the primary Panguna ore mineral assemblage. This attests to ongoing remobilization of sediment and/or reflects mobilization of additional Cu bearing material from the waste rock dump of the Panguna mine. Copper in surface and river sediments is also contained in secondary Cu-phases such as covellite as well as hydrated basic Cu-sulfates, which formed under locally variable redox conditions. Fe-oxihydroxides, occurring in variable abundance as reflected by Fe concentrations between 18,200 and 379,000 mg/kg (Mn 145–3086 mg/kg), can be identified as further Cu-carriers, taking up the metal from the aqueous phase in the sedimentary pore space. Mine derived input of Cu bearing minerals is confined to the sedimentary body of the Jaba-Kawerong river system. The diversity of Cu bearing phases with different environmental and processing properties sets constraints on re-processing sediments as secondary Cu-ores or re-using of sediments as building material.
How Well Do Endemic Wetland Plant Species Perform in Water Purification?
Authors: Frenzel Philip , Brunings Olivia , Esler Karen J. , le Maitre David , Rebelo Alanna J. 
Published: November 2024

AbstractRising anthropogenic-induced nutrient enrichment of surface waters is of great concern globally as it jeopardizes the ecological integrity and functioning of freshwater ecosystems. Floating wetlands have been successfully used to treat nutrient enriched wastewater in developing nations, and provide additional co-benefits. We aimed to quantify the nutrient removal efficiency of high-potential, endemic wetland species on floating wetlands in different conditions and to understand whether the nutrient uptake process was characterised by key plant functional traits. Two experiments were run under Mediterranean-climate conditions of the Western Cape of South Africa: (1) a closed, oligotrophic mesocosm experiment representing local conditions and (2) a real-life (in-situ) eutrophic application. The mesocosm experiment conducted under oligotrophic local conditions yielded low nitrate, phosphate and ammonium removal rates (34.8–35.2 mgNO3-Nm− 2.d− 1, 10.4–10.7 mgPO4-Pm− 2.d− 1 and 3.6–3.8 mgNH4-Nm−2.d− 1) in comparison to other floating wetland studies globally, yet high removal efficiencies (> 90%). However the eutrophic in-situ experiment demonstrated the potential for these same endemic plants to remove up to 312 g.m− 2 of nitrogen and 47 g.m− 2 of phosphorus per year– which is relatively high compared to similar global research. Cyperus textilis had the highest daily nutrient uptake and content followed by Prionium serratum and Juncus lomatophyllus, while J. lomatophyllus had the greatest nutrient uptake efficiency. Two of the three species (C. textilis and P. serratum) stored significantly more total nutrients in their shoot tissue compared to their root tissue, suggesting that the permanent removal of nutrients from the system is possible through shoot harvesting. Floating wetlands planted with endemic plant species have the potential to remove nutrients effectively and sustainably from eutrophic water and can thus be implemented as low-cost nature-based solutions to mitigate pollution of lentic systems.