bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reconstruction of the mass balance of Muztag Ata No. 15 glacier, eastern Pamir, and its climatic drivers
Authors: ZHU MEILIN , YAO TANDONG , YANG WEI , XU BAIQING , WU GUANJIAN , WANG XIAOJUN , XIE YING 
Published: February 2018

ABSTRACTThe mass-balance of Muztag Ata No. 15 (MZ15) glacier in the eastern Pamir is reconstructed between 1980 and 2012 using an energy-based mass-balance model. The results show that this glacier has been characterized by obvious interannual mass-balance changes during 1980–2012 with a slightly positive mass balance during 1998–2012. Precipitation in the ablation season is a primary driver of these mass-balance fluctuations. Distinct changes in the mass-balance of MZ15 glacier between 1980–1997 and 1998–2012 are thought to be associated with changes in the regionally averaged meridional wind speed and corresponding precipitation in the ablation season. The negative and positive mass-balance phases during 1980–1997 and 1998–2012, respectively, were associated with northerly and southerly wind anomalies in the eastern Pamir and their corresponding decreasing and increasing precipitation. These changes in circulation appear to be linked to the mid-latitude climate. Finally, contrary to the variation of most glaciers on the Tibetan Plateau, glaciers in the Karakoram-western Kunlun-eastern Pamir appear to have retreated more slowly over the past 10 years than during the 1970s-2000. This contrasting trend may be caused by different changes in snowfall and different topography factors in different regions under warming and increased precipitation.
Discretion in property law: a study of judicial correction of registered title
Authors: Cooper SAA 
Published: February 2018

AbstractThis paper examines discretionary decision making in a property law context: the statutory power to correct a mistaken entry on the land register. This discretionary power has importance as an occasion when the allocation of property occurs without fixed rules but is put into the control of the court without guidance on content or goals. The case-law is studied using legal empirical analysis. The judicial approach is described and findings are analysed. The paper relates the conclusions to doctrinal and policy debates in land registration and discusses how the judicial input advances understanding of the registration system as an integrated whole.
SYSTEMATIC REVIEW WITH NETWORK META-ANALYSIS OF RANDOMIZED CONTROLLED TRIALS OF ROTATOR CUFF TEAR TREATMENT
Authors: Kim Seihee , Hwang Jinseub , Kim Min Jee , Lim Jae-Young , Lee Woo Hyung , Choi Ji Eun 
Published: February 2018

Objectives:Rotator cuff tear is the leading cause of the decline in quality of life for older adults, but comparative evidence on treatment effectiveness is lacking. This study systematically reviewed the effects of various rotator cuff tear treatments through a Bayesian meta-analysis of the related randomized clinical trials (RCTs).Methods:We searched nine electronic databases for RCTs evaluating rotator cuff tear treatments from their inception through June 2017. A systematic review was performed following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) and the National Institute for Health and Care Excellence-Decision Support Unit guidelines (Supplementary Table 1). Outcomes included functional improvement, pain one year after surgical treatment, and tendon structural integrity. The Bayesian network meta-analysis was applied for functional improvement and pain, based on an assumption of consistency and similarity. Tendon integrity was reported descriptively.Results:Fifteen RCTs were selected. Patients undergoing physiotherapy after open surgery showed statistically significant functional improvements compared with those undergoing physiotherapy only (mean differences, 9.1 [credible interval, 0.9–17.4]). Open surgery with physiotherapy was associated with a decrease in pain 1 year after treatment compared with when physiotherapy was combined with arthroscopic rotator cuff surgery, mini open surgery, platelet-rich plasma therapy, or physiotherapy alone (absolute value of mean difference 1.2 to 1.4). The tendon integrity results were inconsistent.Conclusions:Some surgical treatments were associated with significant improvement in function and pain, but evidence regarding their comparative effectiveness is still lacking. A well-designed RCT discussing functional and structural treatment outcomes is needed in future.
A compact UWB band-pass filter with a notch band using multi-mode stub-loaded resonators (MM-SLR)
Authors: Karimi Gholamreza , Javidan Fatemeh , Salehi Amir Hossein 
Published: February 2018

AbstractIn this paper, an ultra-wideband (UWB) band-pass filter (BPF) with a sharp notch band is presented. The UWB BPF consists of modified elliptical-ring and multi-mode stub-loaded resonator (MM-SLR). By adding the asymmetric tight coupled lines resonator via input/output (I/O) lines, it can be achieved UWB band-pass response. With adding two bends to the middle resonator, a notch band at 6.86 GHz is created, so that it can be controlled using the mathematical formulas (MF). In the meantime, the equivalent circuit of the middle resonator is obtained using L–C analysis. Measured results of fabricated filter have the advantage such as ultra-wide pass band (flandfHof the defined UWB pass band are 3.776 and 10.42 GHz, which satisfy the requirements of FCC-specified UWB limits), compact size, low insertion loss <0.65 dB and the stop band of the proposed filter is from 11.1 to 16.32 GHz with attenuation of −39.8 to −42.14 dB, respectively. The proposed UWB filter is realized using the substrate with dielectric constant of 2.2 and substrate height of 0.787 mm. Experimental verification is provided and good agreement has been found between simulation and measurement results.
Decomposer food web in a deciduous forest shows high share of generalist microorganisms and importance of microbial biomass recycling
Authors: López-Mondéjar Ruben , Brabcová Vendula , Štursová Martina , Davidová Anna , Jansa Jan , Cajthaml Tomaš , Baldrian Petr 
Published: February 2018

Abstract
Forest soils represent important terrestrial carbon (C) pools where C is primarily fixed in the plant-derived biomass but it flows further through the biomass of fungi and bacteria before it is lost from the ecosystem as CO2 or immobilized in recalcitrant organic matter. Microorganisms are the main drivers of C flow in forests and play critical roles in the C balance through the decomposition of dead biomass of different origins. Here, we track the path of C that enters forest soil by following respiration, microbial biomass production, and C accumulation by individual microbial taxa in soil microcosms upon the addition of 13C-labeled biomass of plant, fungal, and bacterial origin. We demonstrate that both fungi and bacteria are involved in the assimilation and mineralization of C from the major complex sources existing in soil. Decomposer fungi are, however, better suited to utilize plant biomass compounds, whereas the ability to utilize fungal and bacterial biomass is more frequent among bacteria. Due to the ability of microorganisms to recycle microbial biomass, we suggest that the decomposer food web in forest soil displays a network structure with loops between and within individual pools. These results question the present paradigms describing food webs as hierarchical structures with unidirectional flow of C and assumptions about the dominance of fungi in the decomposition of complex organic matter.
Hints on ATGL implications in cancer: beyond bioenergetic clues
Authors: Vegliante Rolando , Di Leo Luca , Ciccarone Fabio , Ciriolo Maria Rosa 
Published: February 2018

AbstractAmong metabolic rearrangements occurring in cancer cells, lipid metabolism alteration has become a hallmark, aimed at sustaining accelerated proliferation. In particular, fatty acids (FAs) are dramatically required by cancer cells as signalling molecules and membrane building blocks, beyond bioenergetics. Along with de novo biosynthesis, free FAs derive from dietary sources or from intracellular lipid droplets, which represent the storage of triacylglycerols (TAGs). Adipose triglyceride lipase (ATGL) is the rate-limiting enzyme of lipolysis, catalysing the first step of intracellular TAGs hydrolysis in several tissues. However, the roles of ATGL in cancer are still neglected though a putative tumour suppressor function of ATGL has been envisaged, as its expression is frequently reduced in different human cancers (e.g., lung, muscle, and pancreas). In this review, we will introduce lipid metabolism focusing on ATGL functions and regulation in normal cell physiology providing also speculative perspectives on potential non-energetic functions of ATGL in cancer. In particular, we will discuss how ATGL is implicated, mainly through the peroxisome proliferator-activated receptor-α (PPAR-α) signalling, in inflammation, redox homoeostasis and autophagy, which are well-known processes deregulated during cancer formation and/or progression.
DZNep inhibits H3K27me3 deposition and delays retinal degeneration in the rd1 mice
Authors: Zheng Shijie , Xiao Lirong , Liu Yu , Wang Yujiao , Cheng Lin , Zhang Junjun , Yan Naihong , Chen Danian 
Published: February 2018

AbstractRetinitis pigmentosa (RP) is a group of inherited retinal degenerative diseases causing progressive loss of photoreceptors. Numerous gene mutations are identified to be related with RP, but epigenetic modifications may also be involved in the pathogenesis. Previous studies suggested that both DNA methylation and histone acetylation regulate photoreceptor cell death in RP mouse models. However, the role of histone methylation in RP has never been investigated. In this study, we found that trimethylation of several lysine sites of histone H3, including lysine 27 (H3K27me3), increased in the retinas of rd1 mice. Histone methylation inhibitor DZNep significantly reduced the calpain activity, delayed the photoreceptor loss, and improved ERG response of rd1 retina. RNA-sequencing indicated that DZNep synergistically acts on several molecular pathways that regulate photoreceptor survival in rd1 retina, including PI3K-Akt and photoreceptor differentiation pathways, revealing the therapeutic potential of DZNep for RP treatment. PI3K-Akt pathway and H3K27me3 form a feedback loop in rd1 retina, thus PI3K inhibitor LY294002 reduces phosphorylation of Ezh2 at serine 21 and enhances H3K27me3 deposition, and inhibiting H3K27me3 by DZNep can activate PI3K-Akt pathway by de-repressing gene expression of PI3K subunits Pik3r1 and Pik3r3. These findings suggest that histone methylation, especially H3K27me3 deposition is a novel mechanism and therapeutic target for retinal degenerative diseases, similar to H3K27me3-mediated ataxia-telangiectasia in Atm
−/−
mouse.
Recent progress and perspectives of space electric propulsion systems based on smart nanomaterials
Authors: Levchenko I. , Xu S. , Teel G. , Mariotti D. , Walker M. L. R. , Keidar M. 
Published: February 2018

AbstractDrastic miniaturization of electronics and ingression of next-generation nanomaterials into space technology have provoked a renaissance in interplanetary flights and near-Earth space exploration using small unmanned satellites and systems. As the next stage, the NASA’s 2015 Nanotechnology Roadmap initiative called for new design paradigms that integrate nanotechnology and conceptually new materials to build advanced, deep-space-capable, adaptive spacecraft. This review examines the cutting edge and discusses the opportunities for integration of nanomaterials into the most advanced types of electric propulsion devices that take advantage of their unique features and boost their efficiency and service life. Finally, we propose a concept of an adaptive thruster.
Unattached kinetochores drive their own capturing by sequestering a CLASP
Authors: Kolenda Caroline , Ortiz Jennifer , Pelzl Marina , Norell Sarina , Schmeiser Verena , Lechner Johannes 
Published: February 2018

AbstractKinetochores that are not attached to microtubules prevent chromosome missegregation via the spindle assembly checkpoint. We show that they also promote their own capturing. Similar to what governs the localization of spindle assembly checkpoint proteins, the phosphorylation of Spc105 by Mps1 allows unattached kinetochores to sequester Stu1 in cooperation with Slk19. The withdrawal of Stu1, a CLASP essential for spindle integrity, from microtubules and attached kinetochores disrupts the organization of the spindle and thus allows the enhanced formation of dynamic random microtubules that span the nucleus and are ideal to capture unattached kinetochores. The enhanced formation of nuclear random microtubules does not occur if Stu1 sequestering to unattached kinetochores fails and the spindle remains uncompromised. Consequently, these cells exhibit a severely decreased capturing efficiency. After the capturing event, Stu1 is relocated to the capturing microtubule and prevents precocious microtubule depolymerization as long as kinetochores are laterally or incompletely end-on attached.
Aggregating sequences that occur in many proteins constitute weak spots of bacterial proteostasis
Authors: Khodaparast Ladan , Khodaparast Laleh , Gallardo Rodrigo , Louros Nikolaos N. , Michiels Emiel , Ramakrishnan Reshmi , Ramakers Meine , Claes Filip , Young Lydia , Shahrooei Mohammad , Wilkinson Hannah , Desager Matyas , Mengistu Tadesse Wubishet , Nilsson K. Peter R. , Hammarström Per , Aertsen Abram , Carpentier Sebastien , Van Eldere Johan , Rousseau Frederic , Schymkowitz Joost 
Published: February 2018

AbstractAggregation is a sequence-specific process, nucleated by short aggregation-prone regions (APRs) that can be exploited to induce aggregation of proteins containing the same APR. Here, we find that most APRs are unique within a proteome, but that a small minority of APRs occur in many proteins. When aggregation is nucleated in bacteria by such frequently occurring APRs, it leads to massive and lethal inclusion body formation containing a large number of proteins. Buildup of bacterial resistance against these peptides is slow. In addition, the approach is effective against drug-resistant clinical isolates ofEscherichiacoliandAcinetobacterbaumannii, reducing bacterial load in a murine bladder infection model. Our results indicate that redundant APRs are weak points of bacterial protein homeostasis and that targeting these may be an attractive antibacterial strategy.
Photosystem II Subunit S overexpression increases the efficiency of water use in a field-grown crop
Authors: Głowacka Katarzyna , Kromdijk Johannes , Kucera Katherine , Xie Jiayang , Cavanagh Amanda P. , Leonelli Lauriebeth , Leakey Andrew D. B. , Ort Donald R. , Niyogi Krishna K. , Long Stephen P. 
Published: February 2018

AbstractInsufficient water availability for crop production is a mounting barrier to achieving the 70% increase in food production that will be needed by 2050. One solution is to develop crops that require less water per unit mass of production. Water vapor transpires from leaves through stomata, which also facilitate the influx of CO2during photosynthetic assimilation. Here, we hypothesize thatPhotosystem II Subunit S(PsbS) expression affects a chloroplast-derived signal for stomatal opening in response to light, which can be used to improve water-use efficiency. Transgenic tobacco plants with a range ofPsbSexpression, from undetectable to 3.7 times wild-type are generated. Plants with increasedPsbSexpression show less stomatal opening in response to light, resulting in a 25% reduction in water loss per CO2assimilated under field conditions. Since the role of PsbS is universal across higher plants, this manipulation should be effective across all crops.
Highly stretchable carbon aerogels
Authors: Guo Fan , Jiang Yanqiu , Xu Zhen , Xiao Youhua , Fang Bo , Liu Yingjun , Gao Weiwei , Zhao Pei , Wang Hongtao , Gao Chao 
Published: February 2018

AbstractCarbon aerogels demonstrate wide applications for their ultralow density, rich porosity, and multifunctionalities. Their compressive elasticity has been achieved by different carbons. However, reversibly high stretchability of neat carbon aerogels is still a great challenge owing to their extremely dilute brittle interconnections and poorly ductile cells. Here we report highly stretchable neat carbon aerogels with a retractable 200% elongation through hierarchical synergistic assembly. The hierarchical buckled structures and synergistic reinforcement between graphene and carbon nanotubes enable a temperature-invariable, recoverable stretching elasticity with small energy dissipation (~0.1, 100% strain) and high fatigue resistance more than 106 cycles. The ultralight carbon aerogels with both stretchability and compressibility were designed as strain sensors for logic identification of sophisticated shape conversions. Our methodology paves the way to highly stretchable carbon and neat inorganic materials with extensive applications in aerospace, smart robots, and wearable devices.
Coupling between intra- and intermolecular motions in liquid water revealed by two-dimensional terahertz-infrared-visible spectroscopy
Authors: Grechko Maksim , Hasegawa Taisuke , D’Angelo Francesco , Ito Hironobu , Turchinovich Dmitry , Nagata Yuki , Bonn Mischa 
Published: February 2018

AbstractThe interaction between intramolecular and intermolecular degrees of freedom in liquid water underlies fundamental chemical and physical phenomena such as energy dissipation and proton transfer. Yet, it has been challenging to elucidate the coupling between these different types of modes. Here, we report on the direct observation and quantification of the coupling between intermolecular and intramolecular coordinates using two-dimensional, ultra-broadband, terahertz-infrared-visible (2D TIRV) spectroscopy and molecular dynamics calculations. Our study reveals strong coupling of the O-H stretch vibration, independent of the degree of delocalization of this high-frequency mode, to low-frequency intermolecular motions over a wide frequency range from 50 to 250 cm−1, corresponding to both the intermolecular hydrogen bond bending (≈ 60 cm−1) and stretching (≈ 180 cm−1) modes. Our results provide mechanistic insights into the coupling of the O-H stretch vibration to collective, delocalized intermolecular modes.
Eye movement patterns in infants suggest illusory motion perception induced by stationary gradation
Authors: Matsushita Soyogu , Sato Kazuki , Murakami Kosuke , Tsurumi Shuma , Kanazawa So , Yamaguchi Masami K. 
Published: February 2018

AbstractInfants less than 1 year old are known to preferentially look at pictures of motion illusion induced by luminance gradation. However, the mechanisms underlying infant’s perception of motion illusion remain unclear. The current study analyzed the eye movement patterns of infants perceiving a motion illusion induced by stationary luminance gradations (a derivative of the Fraser-Wilcox illusion). Infants produced the same movement patterns that increase the magnitude of illusory motion in adults. We conclude that infants and adults similarly perceive motion illusion.
Stromal C-type lectin receptor COLEC12 integrates H. pylori, PGE2-EP2/4 axis and innate immunity in gastric diseases
Authors: Chang Lin-Li , Hsu Wen-Hung , Kao Mou-Chieh , Chou Chih-Chung , Lin Chung-Cheng , Liu Chung-Jung , Weng Bi-Chuang , Kuo Fu-Chen , Kuo Chao-Hung , Lin Ming-Hong , Wang Chun-Jen , Lin Chun-Hung , Wu Deng-Chyang , Huang Shau-Ku 
Published: February 2018

AbstractTissue stroma is known to be important in regulating Hp-mediated inflammation, but its interaction with Hp and dendritic cells (DCs) remains to be determined. To this end, the potential crosstalk between H. pylori (Hp) infected gastric stromal cells (Hp-GSCs) and DCs was investigated. Primary GSCs from cancerous and adjacent normal tissues were generated from gastric cancer patients, and monocyte-derived DCs were obtained from healthy individuals. Levels of cytokines and prostaglandin E2 (PGE2) were measured by ELISA, and C-type lectin expression in GSCs was assessed by flow cytometry and immunohistochemistry. In a trans-well co-culture system, significantly upregulated DC-derived IL-23 expression was found when DCs were co-cultured with Hp-infected GSCs (Hp-GSCs). Further, PGE2 from Hp-GSCs was discovered to possess the priming effect, which could be inhibited by anti-COLEC12 (Collectin subfamily member 12) Abs, COLEC12 knockdown or when alpha3-fucosyltransferase-null (futB; HP0651) strain of Hp was used. Also, the expression of COLEC12 was co-localized with CD90+ stromal cells in cancerous tissues. Hp-GSCs-conditioned DCs were able to induce the expression of IL-17 from CD4+ T cells, which could be inhibited by IL-23-neutralizing Abs. These results suggested the importance of COLEC12 as a receptor involved in Hp-stromal cell interaction and its subsequent conditioning effect on DCs.
Comprehensive Review of Genetic Association Studies and Meta-Analysis on polymorphisms in microRNAs and Urological Neoplasms Risk
Authors: Zhang Ligang , Zhang Meng , Wang Hao , Wang Yangyang , Zhou Jun , Hao Zongyao , Zhang Li , Liang Chaozhao 
Published: February 2018

AbstractGene expression is negatively regulated by microRNAs (miRNAs), which commonly act as tumor oncogenes or suppressors. Previous results were inconsistent concerning the relationship between polymorphisms in miRNAs and risk of urological neoplasms. Here, we conducted a comprehensive literature research on diverse databases aiming at enrolling all eligible studies up to August 31, 2016. A total of 13 publications comprising 29 case-control studies were enrolled for three polymorphisms in three miRNAs. Overall analyses suggested significant associations between miR-146a rs2910164 polymorphism and urological neoplasms risk in allelic, homozygote and recessive models. In the stratified analysis by ethnicity, we uncovered a significant association between rs2910164 polymorphism and risk of urological neoplasms in Asian populations in allelic, homozygote and recessive models. Highlighted, when stratified analysis was conducted by cancer type, rs2910164 polymorphism was also significantly associated with an increased risk of bladder cancer in allelic, homozygote and recessive models. Although for rs11614913 and rs3746444 polymorphisms, overall analyses suggested negative results, for rs11614913 polymorphism, when subgroup analysis was conducted by cancer type, a significantly decreased risk of renal cell cancer was identified in recessive model. In brief, current work indicated that miR-146a rs2910164 polymorphism is a risk factor for urological neoplasms, particularly for bladder cancer.