bluuebunny/crossref_metadata_2025_split huggingface dataset:
The association between albumin‐dNLR score and disease activity in patients with rheumatoid arthritis
Authors: Chen Shuaishuai , Ying Haijian , Du Juping , Zhu Xiaoli , Shi Jianfeng , Zhang Ying , Chen Shiyong , Shen Bo , Li Jun 
Published: October 2018

BackgroundRecently, clinical studies have described an association between albumin and the derived neutrophil to lymphocyte ratio (dNLR) with several diseases. This study was aimed to investigate the albumin‐dNLR (ALB‐dNLR) score in rheumatoid arthritis (RA) patients and assess its relationship with clinical and laboratory parameters of RA.MethodsWe retrospectively enrolled 127 RA patients, 155 osteoarthritis (OA) patients, and 155 healthy controls. The ALB‐dNLR score was based on serum albumin level, neutrophil count, and white cell count. The Spearman's rank test was used to measure the correlations between ALB‐dNLR score and disease activity as well as laboratory indexes.ResultsThe ALB‐dNLR score was significantly higher in RA patients than in OA patients (P < 0.001) and in healthy controls (P < 0.001). The proportion of higher ALB‐dNLR score has been raised along with increased disease activity (P < 0.001). The Spearman's rank test showed that ALB‐dNLR score was positively associated with DAS28 score, CRP, ESR, IgA, and platelet count. Moreover, the receiver operating characteristic (ROC) curve showed that the area under the curve (AUC) of ALB‐dNLR was 0.693 (95% CI: 0.631‐0.755), which was higher than that of albumin (AUC: 0.625, 95% CI: 0.559‐0.692) and dNLR (AUC: 0.680, 95% CI: 0.617‐0.743) alone.ConclusionsThe results demonstrate that the ALB‐dNLR score increased in RA patients. The ALB‐dNLR score may be a useful marker to estimate the disease activity of RA patients.
Extending edge‐colorings of complete hypergraphs into regular colorings
Authors: Bahmanian Amin 
Published: October 2018

AbstractLet be the collection of all ‐subsets of an ‐set . Given a coloring (partition) of a set , we are interested in finding conditions under which this coloring is extendible to a coloring of so that the number of times each element of appears in each color class (all sets of the same color) is the same number . The case was studied by Sylvester in the 18th century and remained open until the 1970s. The case is extensively studied in the literature and is closely related to completing partial symmetric Latin squares. For , we settle the cases , and completely. Moreover, we make partial progress toward solving the case where . These results can be seen as extensions of the famous Baranyai’s theorem, and make progress toward settling a 40‐year‐old problem posed by Cameron.
Generating near‐bipartite bricks
Authors: Kothari Nishad 
Published: October 2018

AbstractCarvalho, Lucchesi and Murty (2006, How to build a brick, Discrete Math., 306, 2383‐2410) gave a generation procedure for bricks. In particular, they showed that every brick may be constructed from , the triangular prism , and the Petersen graph. The object of this paper is to establish a generation procedure that is specific to the class of near‐bipartite bricks. In particular, we show that every near‐bipartite brick may be constructed from and so that each intermediate brick is also near‐bipartite. Norine and Thomas (2007, Generating bricks, J. Combin. Theory Ser. B, 97, 769‐817) proved a generation theorem for simple bricks. In a subsequent work with Marcelo H. de Carvalho (2017, Generating simple near‐bipartite bricks, https://arxiv.org/abs/1704.08796), we use the results of this paper to prove a generation theorem for simple near‐bipartite bricks.
MRI in donor candidates for living donor liver transplant: Technical and practical considerations
Authors: Kim Bohyun , Kim So Yeon , Kim Kyoung Won , Jang Hye Young , Jang Jong Keon , Song Gi Won , Lee Sung Gyu 
Published: October 2018

In living donor liver transplantation (LDLT), a thorough preoperative evaluation of the donor is imperative to minimize the risk of the donors and improve the outcome of the recipients. In order to select the best candidate, knowledge of the liver volume, degree of steatosis, and anatomic variations in the vascular and biliary system in potential donors is crucial. With recent technical advances, magnetic resonance imaging (MRI) is increasingly replacing the need for computed tomography (CT) examination in essential steps of donor evaluation. Along with the introduction of higher gradient strength, novel pulse sequences, and innovative contrast media, MRI has a potential to serve as an “all‐in‐one” imaging package. In this review, we provide an overview of clinical and radiologic considerations related to LDLT and highlight the basics and up‐to‐date knowledge of MRI techniques for a comprehensive donor evaluation.Level of Evidence: 5Technical Efficacy: Stage 5J. Magn. Reson. Imaging 2018;48:1453–1467
Detecting perfusion deficit in Alzheimer's disease and mild cognitive impairment patients by resting‐state fMRI
Authors: Yan Shaozhen , Qi Zhigang , An Yanhong , Zhang Mo , Qian Tianyi , Lu Jie 
Published: October 2018

BackgroundVascular factors contributing to cerebral hypoperfusion are implicated in the risk of developing Alzheimer's disease (AD).PurposeTo investigate the time‐shift mapping created time‐shift value of the brain by resting‐state functional magnetic resonance imaging (rs‐fMRI), and to determine the differences in time‐shift value among AD, mild cognitive impairment (MCI), and normal control (NC) groups to better understand the disease.Study TypeProspective.SubjectsTwenty‐four AD, 24 MCI, and 24 age‐matched NC participants.Field Strength/SequenceT2*‐weighted single‐shot echo‐planar imaging sequence was performed at 3T. In addition, a T1‐weighted fast spoiled gradient‐echo sequence was acquired for coregistration.AssessmentThe brain time‐shift value was determined from rs‐fMRI‐based blood oxygenation level‐dependent (BOLD) signal in the three groups by time‐shift mapping. The perfusion patterns were also investigated in the NC group.Statistical TestsOne‐way analysis of variance and chi‐squared tests were used to compare demographic information. The normalized time‐shift maps were analyzed in a second‐level test using SPM8. All analyses were evaluated with a significance level of P < 0.05 after false discovery rate (FDR) correction.ResultsThe time‐shift maps obtained from rs‐fMRI are consistent with the cerebral blood supply atlas. Compared with NC, both MCI and AD groups had less early perfusion arrival areas among the whole brain. In the delayed time‐shift value for the AD group, the areas were located in the bilateral precuneus, the sensory‐motor cortex in the left hemisphere, and the bilateral calcarine sulcus, which were different from the MCI group (both P < 0.05, FDR corrected).Data ConclusionThe time‐shift mapping method could detect perfusion deficits in AD and MCI noninvasively. The perfusion deficits detected by rs‐fMRI may provide new insight for understanding the mechanism of neurodegeneration.Level of Evidence 2Technical Efficacy Stage 3J. Magn. Reson. Imaging 2019;49:1099–1104.
Hepatic R2* is more strongly associated with proton density fat fraction than histologic liver iron scores in patients with nonalcoholic fatty liver disease
Authors: Bashir Mustafa R. , Wolfson Tanya , Gamst Anthony C. , Fowler Kathryn J. , Ohliger Michael , Shah Shetal N. , Alazraki Adina , Trout Andrew T. , Behling Cynthia , Allende Daniela S. , Loomba Rohit , Sanyal Arun , Schwimmer Jeffrey , Lavine Joel E. , Shen Wei , Tonascia James , Van Natta Mark L. , Mamidipalli Adrija , Hooker Jonathan , Kowdley Kris V. , Middleton Michael S. , Sirlin Claude B. ,   on behalf of the NASH Clinical Research Network (NASH CRN)
Published: October 2018

BackgroundThe liver R2* value is widely used as a measure of liver iron but may be confounded by the presence of hepatic steatosis and other covariates.PurposeTo identify the most influential covariates for liver R2* values in patients with nonalcoholic fatty liver disease (NAFLD).Study TypeRetrospective analysis of prospectively acquired data.PopulationBaseline data from 204 subjects enrolled in NAFLD/NASH (nonalcoholic steatohepatitis) treatment trials.Field Strength1.5T and 3T; chemical‐shift encoded multiecho gradient echo.AssessmentCorrelation between liver proton density fat fraction and R2*; assessment for demographic, metabolic, laboratory, MRI‐derived, and histological covariates of liver R2*.Statistical TestsPearson's and Spearman's correlations; univariate analysis; gradient boosting machines (GBM) multivariable machine‐learning method.ResultsHepatic proton density fat fraction (PDFF) was the most strongly correlated covariate for R2* at both 1.5T (r = 0.652, P < 0.0001) and at 3T (r = 0.586, P < 0.0001). In the GBM analysis, hepatic PDFF was the most influential covariate for hepatic R2*, with relative influences (RIs) of 61.3% at 1.5T and 47.5% at 3T; less influential covariates had RIs of up to 11.5% at 1.5T and 16.7% at 3T. Nonhepatocellular iron was weakly associated with R2* at 3T only (RI 6.7%), and hepatocellular iron was not associated with R2* at either field strength.Data ConclusionHepatic PDFF is the most influential covariate for R2* at both 1.5T and 3T; nonhepatocellular iron deposition is weakly associated with liver R2* at 3T only.Level of Evidence: 4Technical Efficacy: Stage 2J. Magn. Reson. Imaging 2019;49:1456–1466.
Oroxylin A inhibits Kaposi's sarcoma‐associated herpes virus (KSHV) vIL‐6–mediated lymphatic reprogramming of vascular endothelial cells through modulating PPARγ/Prox1 axis
Authors: Zhu Xiaofei , Chen Yun , Zhu Wenqiang , Ji Mingde , Xu Jing , Guo Yuanyuan , Gao Feng , Gu Wanjian , Yang Xuewen , Zhang Chunbing 
Published: October 2018

AbstractBackground and purposeKaposi's sarcoma–associated herpes virus (KSHV) vIL‐6 is sufficient to induce lymphatic reprogramming of vascular endothelial cells, which is a key event in Kaposi's sarcoma (KS) development. This study was aimed to investigate the effect of Chinese herb oroxylin A on lymphatic reprogramming and neovascularization by KSHV vIL‐6 in vitro and in vivo.MethodsThe lymphatic‐phenotype endothelial cell line was generated by lentiviral KSHV vIL‐6 infection. Cell viability and apoptosis were determined by MTT assay or flow cytometry with annexin V/propidium iodide staining. Migration, invasion, and neovascularization of the vIL‐6‐expressing lymphatic‐phenotype endothelial cells were determined by wound healing assay, transwell chamber assay, microtubule formation assay, and chick chorioallantoic membrane assay, respectively. Quantitative polymerase chain reaction and Western blot analysis were used to test the expression of Prox1, VEGFR3, podoplanin, LYVE‐1, and PPARγ in cells. Co‐localization of Prox1 and PPARγ was determined by immunofluorescence. Ubiquitination of Prox1 was detected by in vivo ubiquitination assay.ResultsThe lymphatic‐phenotype endothelial cell line expressing KSHV vIL‐6 was successfully generated. Oroxylin A induced cellular invasion abrogation, apoptosis induction, and neovascularization inhibition of the vIL‐6‐expressing endothelial cells. Mechanically, oroxylin A elevated PPARγ expression, which in turn interacted with and facilitated Prox1 to undergo ubiquitinational degradation, and subsequently leads to VEGFR3, LYVE‐1, and podoplanin reduction.ConclusionThrough modulating PPARγ/Prox1 axis, oroxylin A inhibits lymphatic reprogramming and neovascularization of KSHV vIL‐6. Thus, oroxylin A may serve as a candidate for the treatment of KS as well as other aggressive angiomas.
Prevalence of human herpesviruses infections in nonmalignant tonsils: The SPLIT study
Authors: Kourieh Aboud , Gheit Tarik , Tommasino Massimo , Dalstein Véronique , Clifford Gary M. , Lacau St Guily Jean , Clavel Christine , Franceschi Silvia , Combes Jean‐Damien ,   for the SPLIT study group
Published: October 2018

ObjectiveTo assess the prevalence of all known human herpesviruses (HHV) in tonsils of an age‐stratified large sample of immunocompetent children and adults.MethodsPatients undergoing tonsillectomy for benign indications were recruited in 19 French hospitals. After resection, the entire outer surfaces of right and left half tonsils were extensively brushed. A highly sensitive species‐specific multiplex assay was used to detect herpes simplex virus 1 (HSV1), HSV2, Epstein‐Barr virus (EBV; types 1 and 2), and human cytomegalovirus (CMV) DNA in 688, as well as varicella zoster virus (VZV), HHV6A, HHV6B, HHV7, and Kaposi's sarcoma‐associated herpesvirus (KSHV) DNA in a subset of 440 tonsil brushings.ResultsOverall 85% of tonsil brushing samples were infected with at least one HHV species. HHV7 and EBV were the most prevalent (≈70%), followed by HHV6B (≈50%), HSV1, CMV, VZV (≈2%), and KSHV and HSV2 (<1%), while HHV6A was not detected. EBV prevalence was significantly higher in adults than in children, whereas it was opposite for HHV6B and VZV. No difference in HHV prevalence was observed by sex. In multivariate analysis, EBV detection was associated with age greater than or equal to 15 years (prevalence ratio [PR] = 1.8; 95% confidence interval [CI]: 1.5‐2.3) and marginally with tobacco smoking (PR = 1.2; 95% CI: 1.1‐1.3).ConclusionDiffering patterns of HHV infection in tonsils in a large age‐stratified population were described. This study is by far the largest available and shows that EBV, HHV6B, and HHV7 are commonly detected in the tonsils in both men and women, in contrast to other HHVs.
Zebrafish models for personalized psychiatry: Insights from individual, strain and sex differences, and modeling gene x environment interactions
Authors: Volgin Andrey D. , Yakovlev Oleg A. , Demin Konstantin A. , de Abreu Murilo S. , Alekseeva Polina A. , Friend Ashton J. , Lakstygal Anton M. , Amstislavskaya Tamara G. , Bao Wandong , Song Cai , Kalueff Allan V. 
Published: October 2018

AbstractCurrently becoming widely recognized, personalized psychiatry focuses on unique physiological and genetic profiles of patients to best tailor their therapy. However, the role of individual differences, as well as genetic and environmental factors, in human psychiatric disorders remains poorly understood. Animal experimental models are a valuable tool to improve our understanding of disease pathophysiology and its molecular mechanisms. Due to high reproduction capability, fully sequenced genome, easy gene editing, and high genetic and physiological homology with humans, zebrafish (Danio rerio) are emerging as a novel powerful model in biomedicine. Mounting evidence supports zebrafish as a useful model organism in CNS research. Robustly expressed in these fish, individual, strain, and sex differences shape their CNS responses to genetic, environmental, and pharmacological manipulations. Here, we discuss zebrafish as a promising complementary translational tool to further advance patient‐centered personalized psychiatry.
Ammonia losses from urea applied to winter wheat over four consecutive years and potential mitigation by urease inhibitors
Authors: Schraml Martine , Weber Andreas , Heil Kurt , Gutser Reinhold , Schmidhalter Urs 
Published: October 2018

AbstractUrea is not only the most important mineral nitrogen (N) fertilizer worldwide, but it is also the mineral N fertilizer with one of the highest potential for ammonia (NH3) losses. The European emission inventory guidebook estimates an average loss of 16% of the applied urea as NH3. For mitigating NH3 losses from urea, the best option would be to immediately incorporate the fertilizer. However, the addition of a urease inhibitor (UI) represents a potent alternative. In a multi‐year experiment from 2002 to 2005, 17 measurement periods were conducted in winter wheat (Triticum aestivum L.) and on bare soil in Southern Germany to evaluate the extent of NH3 losses following the application of urea and to determine the mitigating effect of urease inhibitors. In all measurement periods, 80 kg N ha−1 as urea without or with the UI N‐(n‐butyl) thiophosphoric triamide (nBTPT) 0.3% w/w or N‐(isopropoxycarbonyl) phosphoric acid triamide (IPAT) 0.4% w/w were applied. For 6–24 d following fertilizer application, NH3 emissions were continuously measured using a dynamic chamber system. Generally, low NH3 emissions were detected from urea, varying between 0.1 and 2.7% of the N applied to winter wheat and between 2.6 and 16.3% of the N applied on bare soil. Addition of the UIs IPAT and nBTPT had a significant effect on the course of NH3 emissions and reduced losses on average by 32% and 24%, respectively.
Oxidation evaluation of free astaxanthin and astaxanthin esters in Pacific white shrimp during iced storage and frozen storage
Authors: Qiao Xing , Yang Lu , Gao Qun , Yang Shu , Li Zhaojie , Xu Jie , Xue Changhu 
Published: October 2018

AbstractBACKGROUNDIn this paper, the changes in free astaxanthin (F‐AST) and astaxanthin esters (AST‐Es) in Litopenaeus vannamei during iced storage and frozen storage were investigated. The liquid chromatography–atmospheric pressure chemical ionization tandem mass spectrometry method was used to quantify the molecular species of AST‐Es in shrimp during storage.RESULTSBased on the analysis of autoxidation products, apo‐12‐astaxanthinal and apo‐13‐astaxanthinone docosahexaenoic acid (DHA) ester were identified as the major oxidation products of F‐AST and AST‐Es in L. vannamei during storage. The total astaxanthin (T‐AST) content decreased by 34.51% after 7 days in iced storage. In contrast, the content of T‐AST decreased by 43.76% after 12 weeks in frozen storage. The content of F‐AST decreased by 29.99% while 13‐cis‐astaxanthin increased after 3 days in iced storage, which indicated that degradation of AST was accompanied by isomerization. Total volatile basic nitrogen and T‐AST content showed a significant negative correlation while in frozen storage, where the concentration of T‐AST might be one indicator to evaluate shrimp freshness.CONCLUSIONThe correlation coefficients between phenol oxidase, lipoxygenase, apo‐12‐astaxanthinal, and apo‐13‐astaxanthinone DHA ester were all greater than 0.97 (P < 0.01). This correlation indicates that phenol oxidase and lipoxygenase were the main internal factors to improve oxygenation of astaxanthin in L. vannamei. These results provide a theoretical basis for further study of oxidation and the degradation mechanism in astaxanthin, as well as a new idea for the development and utilization of astaxanthin compounds in Pacific white shrimp. © 2018 Society of Chemical Industry
Hunters’ responses to urine‐based scent bans tackling chronic wasting disease
Authors: Song Hwanseok , McComas Katherine A. , Schuler Krysten L. 
Published: October 2018

ABSTRACTWildlife managers and researchers have suspected that urine‐based lure products collected from captive cervids could be potential media contributing to the spread of chronic wasting disease (CWD) in deer (Odocoileus spp.). Although personnel in multiple wildlife agencies have taken the precautionary approach to prohibit the sales or use of urine‐based lure products, it is not well understood whether hunters will accept and willingly cooperate with these policies. To address this gap in the literature, we examine hunters’ attitudes and behavioral intentions toward a hypothetical policy proposing to ban urine‐based products and how risk beliefs, trait psychological reactance, and hunting experience affect these responses. In May 2017, we recruited 739 members of an online advocacy group of deer hunters to complete a web‐based survey with experimental elements. Overall, participants held positive attitudes toward the proposed policy to ban these products and high intentions to cooperate. Participants also characterized CWD as an increasing risk that was associated with dread, well known to science, and observable. These risk beliefs were positively related to attitudes and behavioral intentions to comply with the policy. In contrast, trait psychological reactance and prior experience using urine‐based scents were negatively related to attitudes and behavioral intentions. Findings indicate that wildlife management agency personnel communicating with the public may find better acceptance of controversial CWD policies by first establishing a shared understanding of its risks through thorough risk communication. © 2018 The Wildlife Society.
Is HPV‐Associated Oropharyngeal Cancer Becoming More Common in Older Patients?
Authors: Thompson James D. , Harari Paul M. , Hartig Gregory K. 
Published: October 2018

ObjectiveTo evaluate changing age demographics over a 15‐year period for patients with HPV‐associated oropharyngeal squamous cell carcinoma (OPSCC).Study DesignRetrospective review of patients identified with p16‐positive OPSCC at our institution over a 15‐year timeframe.
Materials/Methods: p16‐positive immunohistochemistry was used as a surrogate for HPV‐associated OPSCC. Patients were categorized according to year of diagnosis (2002‐2010 versus 2011‐2016). Mean age and proportion of patients over age 65 were statistically evaluated and compared.ResultsFrom 2002 to 2010, 100 patients were identified with p16‐positive OPSCC, mean age at diagnosis was 55.2, and the proportion of patients over 65 was 10.0%. From 2011 to 2016, 188 patients were identified with p16‐positive OPSCC, mean age was 58.5, and the proportion of patients over 65 was 19.6%. Both the mean age difference and the difference in proportion of patients over 65 were statistically significant (P = .001 and P = .034, respectively).ConclusionThe mean age at diagnosis and proportion of patients over 65 has increased over the past 15 years at our institution. This data suggests that HPV‐associated OPSCC is being diagnosed more frequently in older persons and that the age demographic may be shifting. Confirmation of this trend with larger patient numbers on a national level will be valuable. This study highlights the importance of maintaining a high clinical suspicion for HPV‐associated OPSCC regardless of patient age.Level of evidence4
The impacts of iron limitation and ocean acidification on the cellular stoichiometry, photophysiology, and transcriptome of Phaeocystis antarctica
Authors: Koch Florian , Beszteri Sara , Harms Lars , Trimborn Scarlett 
Published: October 2018

Abstract
Phaeocystis antarctica is an integral player of the phytoplankton community of the Southern Ocean (SO), the world's largest high‐nutrient low‐chlorophyll region, and faces chronic iron (Fe) limitation. As the SO is responsible for 40% of anthropogenic CO2 uptake, P. antarctica must also deal with ocean acidification (OA). However, mechanistic studies investigating the effects of Fe limitation and OA on trace metal (TM) stoichiometry, transcriptomic, and photophysiological responses of this species, as well as on the Fe chemistry, are lacking. This study reveals that P. antarctica responded strongly to Fe limitation by reducing its growth rate and particulate organic carbon (POC) production. Cellular concentrations of all TMs, not just Fe, were greatly reduced, suggesting that Fe limitation may drive cells into secondary limitation by another TM. P. antarctica was able to adjust its photophysiology in response to Fe limitation, resulting in similar absolute electron transport rates across PSII. Even though OA‐stimulated growth in Fe‐limited and ‐replete treatments, the slight reduction in cellular POC resulted in no net effect on POC production. In addition, relatively few genes were differentially expressed due to OA. Finally, this study demonstrates that, under our culture conditions, OA did not affect inorganic Fe or humic‐acid‐like substances in seawater but triggered the production of humic‐acid‐like substances by P. antarctica. This species is well adapted to OA under all Fe conditions, giving it a competitive advantage over more sensitive species in a future ocean.