bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efecto del ejercicio preprandial sobre el metabolismo intermediario basal y postprandial en pacientes con diabetes tipo 2 de nivel del mar
Authors: Garmendia Fausto , Pando Rosa , Torres William , Valqui Wuili 
Published: July 2019

Introducción. Los pilares terapéuticos del control metabólico de la diabetes mellitus tipo 2 (DM2) son el régimen alimenticio y la actividad física. Objetivo. Estudiar el efecto del ejercicio preprandial de corta duración y ocasional sobre el metabolismo intermediario basal y postprandial en personas con DM2. Métodos. Estudio experimental, transversal, en 16 mujeres y 15 varones con DM2, de nivel del mar, de 40 a 68 años, sometidos a dos pruebas, basal (A) y a post-ejercicio preprandial (B), consistente en una caminata durante 30 minutos a 4 Km/hora en faja sin fin. En ayunas y luego de un desayuno con 730 Kcal., 55,4% de grasas, 37,2% de hidratos de carbono y 7,34% de proteínas, se midió en sangre, glucosa, colesterol total, colesterol HDL, triglicéridos, insulina y ácidos grasos no esterificados (AGNE) durante 6 horas . El colesterol VLDL, LDL NoHDL y HOMA fueron calculados. Resultados. El ejercicio determinó una disminución de las concentraciones de glucosa, insulina y AGNE en la fase postprandial. Conclusión. El ejercicio mejoró elcontrol metabólico postprandial en DM2.
Alma Ata: experiencias que validan sus propuestas 40 años después, para proyectarlas al futuro
Authors: Carbone Campoverde Fernando , Tejada de Rivero David , Sánchez Temístocles , Ormachead José , Sánchez Ignacio 
Published: July 2019

Mucho se ha discutido sobre porqué después de la Conferencia Internacional de Salud de Alma Ata de 1978, no se siguió un impulso que hiciera posible su implementación y más bien la salud discurriera por corrientes no solo distintas sino opuestas en algunos casos. Si bien es cierto que esta discusión es importante para entender mejor las lecciones aprendidas en torno a la denominada atención primaria de salud (APS), evitar los errores y profundizar sus aciertos, es más importante operativizar, en el sentido que Alma Ata propuso, modelos de salud integrales e incluyentes que reflejen la justicia, la equidad, la innovación y la audacia necesarias para construir un mundo mejor, más justo, saludable, desarrollado y feliz. En las Américas hay experiencias relativamente recientes que abogan por ello, que es importante presentar inicialmente, ya que están aún en proceso de sistematización e investigación.
Prevención y manejo clínico de pre eclampsia y eclampsia: Guía de práctica clínica basada en evidencias del instituto de referencia nacional en salud materna del Perú
Authors: Guevara Ríos Enrique , Pérez Aliaga Carlos , De la Peña Meniz Walter , Limay Ríos Oscar , Meza Santibáñez1 Luis , Ching Ganoza Silvia , Rojas Aguedo Miriam , Huayanay Bernabé Marlene , Gonzales Carrillo Oswaldo , Luna Figueroa Antonio , Orihuela Salazar Jenby , Angulo Rivera Nelly , Huamán Sánchez Karen , Carmona Clavijo Gloria , Bonilla Untiveros Catherine , Castillo Villacrez Celia , Reyes Puma Nora , Caballero Ñopo Patricia 
Published: July 2019

Introducción. En Perú, los trastornos hipertensivos del embarazo son la segunda causa de mortalidad materna. Objetivo. La presente guía de práctica clínica basada en evidencias (GPC-BE) brinda recomendaciones para la prevención y tratamiento de la pre-eclampsia y eclampsia. Métodos. Se elaboró una GPC-BE adaptada mediante un proceso sistemático, riguroso y transparente con un grupo elaborador conformado por metodólogos y profesionales de la salud expertos en el manejo de la enfermedad. La guía cuenta con dieciséis preguntas clínicas y dieciséis recomendaciones. Se realizó la búsqueda y preselección de GPC, las mismas que fueron evaluadas mediante el instrumento “Appraisal of Guidelines for Research and Evaluation II” (AGREEII), para su adaptación. La búsqueda sistemática de evidencias para responder las preguntas clínicas se realizó en múltiples bases de datos: MEDLINE/PubMed, EMBASE/Ovid, Cochrane Library, LILACS y SciELO. Las evidencias fueron seleccionadas y analizadas críticamente por pares clínicos y metodológicos; las recomendaciones fueron elaboradas mediante la metodología Grading of Recommendations Assessment, Development, and Evaluation (GRADE). Resultados. Con la participación de un panel de expertos clínicos del Instituto Nacional Materno Perinatal, redes de salud y otras instituciones de referencia, se elaboraron 16 recomendaciones dirigidas a la prevención y tratamiento de mujeres gestantes en riesgo de pre-eclampsia, gestantes con pre-eclampsia, eclampsia o enfermedad hipertensiva. Conclusiones. Este artículo resume la guía de práctica clínica basada en evidencias para la prevención y tratamiento de pre-eclampsia y eclampsia en gestantes en el instituto de referencia nacional en salud materna y neonatal del Perú.
Guía de práctica clínica para el manejo de pacientes con fibrilación auricular en el Seguro Social del Perú (EsSalud)
Authors: Soto-Becerra Richard , Zafra-Tanaka Jessica Hanae , Goicochea-Lugo Sergio , Alarcón-Ruiz Christoper A. , Pacheco-Barrios Kevin , Taype-Rondan Alvaro , Guevara-Caicedo Carolina , Espinoza-Rivas Gladys , Cabrera-Saldaña Mario , Zelaya-Castro Pío , Zegarra-Carhuaz Ricardo , Urday-Ipanaqué Diana , Timaná-Ruiz Raúl 
Published: July 2019

Introducción. El presente artículo resume la guía de práctica clínica (GPC) para el manejo de pacientes con fibrilación auricular (FA) en el Seguro Social del Perú (EsSalud). Objetivo. Proveer recomendaciones clínicas basadas en evidencia para el manejo de pacientes con FA en EsSalud. Métodos. Se conformó un grupo elaborador (GEG) que incluyó médicos especialistas y metodólogos. El GEG formuló 9 preguntas clínicas a ser respondidas por la presente GPC. Se realizó búsquedas sistemáticas de revisiones sistemáticas y ,cuando fue considerado pertinente, estudios primarios en Medline durante el 2017. Se seleccionó la evidencia para responder cada una de las preguntas clínicas planteadas. La certeza de la evidencia fue evaluada usando la metodología Grading of Recommendations Assessment, Development, and Evaluation (GRADE). En reuniones de trabajo periódicas, el GEG usó la metodología GRADE para revisar la evidencia y formular las recomendaciones, los puntos de buenas prácticas clínicas y los flujogramas de la GPC. Finalmente, la GPC fue aprobada con Resolución N° 91 – IETSI – ESSALUD – 2018. Resultados. La presente GPC abordó 9 preguntas clínicas, divididas en tres temas: prevención de eventos tromboembólicos, estrategias de control y manejo de FA en emergencias. En base a dichas preguntas se formularon 12 recomendaciones (6 recomendaciones fuertes y 6 recomendaciones condicionales), 29 puntos de buena práctica clínica, y 2 algoritmos. Conclusión. El presente artículo resume la metodología y las conclusiones basadas en evidencias de la GPC para manejo de pacientes con FA en EsSalud.
تنمية القواعد العربية كمادة التعليم فى جامعة إمام بنجول الإسلاميّة الحكوميّة بادنج
Authors: Jarir Muhammad , Hanafi Abdul Halim 
Published: July 2019

الغرض من هذاالبحث هو تنمية نموذج مواد تعليم القواعد فى قسم تعليم اللغة العربية لكلية التربية وتاهيل المعلمين جامعة إمام بونجول الاسلامية الحكومية بادانج باسعمال منهج البحث التنمي. وجدت نتيجة البحث أن الوثائق المعلقة بتعليم القواعد وحاجات المدرسين والطلاب تصوِّر نموذج مادة تعليم القراعد هي مادة القواعد التطبيقية أى تجمع بين تعليم القواعد و اللغة العربية بالمدخل الاستقرائى أي من الأمثلة الى الشرح والى التدريبات والى الخلاصة أو القاعدة. فوجد الطلاب مادتين، القواعد واللغة العربية الرسمية ةالعملية. وهذه الكيفية مناسبة بحاجة المدرسين والطلاب لفهم مادة القواعد.
MODERN RUSSIAN-TURKISH RELATIONS: PERSONAL ASPECT
Authors: ODINOKOV Andrey S. 
Published: July 2019

Relevance.The specificity of Russian-Turkish relations over several decades has been considered. It was determined that Putin, as well as Erdogan, headed the Russian Federation at a difficult moment: the internal socio-political situation in the country was characterized by destructive trends, the mood in society was also pessimistic, on the world stage of the Russian Federation it consistently lost its position of the state - successor of the USSR, a significant geopolitical center .Method or methodology of the work.The work used statistical, factor and structural research method.Results.The thesis was formulated that the activity, dynamics of bilateral relations - socio-political, foreign economic, in the field of military cooperation, etc. - always reveals a significant (in some cases - dominant) factor the specifics of personal relations at the level of heads of state, members of the government. The specificity of partnerships between V. Putin and R. Erdogan in the period up to 2016 is considered.Conclusions.The specificity of the parties to overcome this difficult stage of relations is considered. The content of the message of R. Erdogan to Putin was considered, and within the framework of which the provision was formulated that the Russian Federation is a friend of Turkey, its strategic partner.Novelty.The specifics of the positions of the parties regarding the incident with the Russian fighter shot down by the Turkish side were determined. It was noted that mutual misunderstandings developed into a phase of open conflict, which became the basis for the introduction of sanctions against Turkey by the Russian side.
Atherosclerotic changes in aorta and coronary arteries at autopsy in North Indian population
Authors: Khanna Kunal , Garg Varun , Khanagwal Vijay Pal , Dagar Tarun , Paliwal Pramod Kumar , Sen Rajeev 
Published: July 2019

Background: Cardiovascular disease (CVD) has become a ubiquitous cause of morbidity and a leading contributor to mortality in most countries. It has emerged as a major health burden worldwide with atherosclerosis being the major cause.Methods: 150 random cases of different age groups brought for postmortem examination in the Department of Forensic Medicine PGIMS, Rohtak. Heart was removed and examined after obtaining the consent of next of the kin of the deceased. Gross macroscopic changes were noted and microscopic changes examination was done and reported by preparation of slides in collaboration with Department of Pathology of the Institute.Results: The study group comprised of mostly males (70%) with mean age of 36.90±13.88 years. Almost half of them were in their third and fourth decade of life. 83 cases were found to have atherosclerosis and 25 of them belonged to the age group 40 to 49 years. 82 % of these cases were of male gender. Histopathological grading carried out displayed that Grade III lesions were maximum (27.5%) followed by grade IV lesions (19.0%) and in no section grade VIII lesions were seen.Conclusion: Atherosclerosis has emerged as a new epidemic affecting at a relatively younger age. This study would help in planning of preventive measures directed at the right population. Clinicians could take measures at an early stage to prevent the progression of the disease and will help forensic pathologists in dealing with opinion regarding cause of death.
Microfilarae in malignant mesothelioma associated pleural effusion with blood microfilaremia: a rare association
Authors: Sharma Dinesh Chandra , Sharma Deepanjali 
Published: July 2019

Filariasis has a wide spectrum of presentation and usually involves the lung in the form of tropical pulmonary eosinophilia with pulmonary infiltrates and peripheral eosinophilia. Filariasis presenting with pleural effusion is an unusual presentation. Malignancy in association with filarial pleural effusion is extremely rare. In this context, we hereby report a case of 45 year old male who presented with right sided chest pain, cough, fever and generalized weakness. Pleural fluid cytology revealed microfilaria and pleural biopsies from pleural nodules confirmed malignant mesothelioma. Peripheral blood smears taken at night exhibited microfilaria with normal eosinophil counts, which is further uncommon. Role of filariasis in tumorigenesis is controversial.
Premarital sexual practices and associated factors among high school students in Hawassa city in Ethiopia, 2018: institutional-based cross sectional study design
Authors: Selgado Melkamu B. 
Published: July 2019

<p class="abstract"><strong>Background:</strong> Youth reproductive health problems have been an issues of worldwide especially Africa countries, including Ethiopia; in addition to these population took more than two-third of overall population. To address problems effectively, up to date information on adolescent premarital sexual practices and factors related was needed. To determine the magnitude of pre-marital sexual practices and associated factors among high school students in Hawassa city, Ethiopia 2018.</p><p class="abstract"><strong>Methods:</strong> School based cross-sectional study was conducted among randomly selected sample of high school students of Hawassa city from October 12-22, 2018. A total of 813 students were participated in the study. Data were collected using anonymous self-administered questionnaire. After data was collected, it was coded and entered in to the computer using EPIinfo software and finally exported to SPSS version 21 for analysis. Descriptive statistics was computed to describe basic socioeconomic and demographic characteristics of the participants. Bivariate logistic analysis was done to know the candidate variables (p value less than or equals to 0.25) for multivariate logistic regression analysis to determine significantly associated variable with outcome of interest. </p><p class="abstract"><strong>Results:</strong> Study revealed that magnitude of premarital sexual intercourse found to be 11.9% (61 were males and 39 females) of 813 total sample. Drinking alcohol with AOR: l8.43; 95% CI (5.12, 13.94), watching pornographic films with AOR: 5.96; 95% CI (3.80, 9.37), educational status of mother with AOR: 7.35; 95% CI (4.56, 11.89), male sex with AOR: 0.48; 95% CI (0.31, 0.75) has statically association with premarital sexual practices.</p><strong>Conclusions:</strong> One in ten students had premarital sexual practice. Moreover, practicing risky sexual behaviors such drinking alcohols, watching pornographic films and mother education status are found to be predicators. Therefore, it is imperative to bring behavioral change through establishing and strengthening school female reproductive health program and empowerment of women in education.
Uniqueness of Dr. JRK’s 777 oil and how rancidity distorts Wrightia tinctoria
Authors: Vadivel Aruna , Venkata Amruthavalli Gatla , Ravi Soundharya , Rajagopal Gayathri 
Published: July 2019

<p class="abstract"><strong>Background:</strong> Several oil based AYUSH formulations are available for the treatment of psoriasis. In the recent time the importance given to <em>Wrightia tinctoria</em> has totally side-lined the quality of oil used in such preparation. Therefore, the importance of oil used in the formulation with reference to rancidity and how that would affect the therapeutic effect of <em>Wrightia tinctoria</em> needs to be studied.</p><p class="abstract"><strong>Methods:</strong> In the present study we have adopted the following methods such as acid value, DPPH assay, nitric oxide inhibition, anti-glycation, CAM assay and fibroblast toxicity. The base oil used was studied for the above then the oil that showed least acid value was incorporated with <em>Wrightia tinctoria</em> extract and then studied by the above methods.<strong></strong></p><p class="abstract"><strong>Results:</strong> The above study clearly show that the activity of <em>Wrightia tinctoria</em> decrease significantly when it was formulated in oil with high rancidity. Whereas the activity of <em>Wrightia tinctoria</em> was well preserved in oil with least rancidity. The contribution of acid value of oil in decreasing the activity of <em>Wrightia tinctoria</em> was much higher than the effect of acid value in increasing DPPH activity, Nitric oxide production, inducing glycation event and angiogenesis and causing fibroblast toxicity.</p><p><strong>Conclusions:</strong> The present study clearly concludes that the acid value of base oil would not only worsen psoriasis but also can inactivate and convert the herbal metabolites to toxic elements. Due diligence is necessary in preparing AYUSH drugs where not only the quality of herbs should be considered but also the oil base as well. </p>
Effect of Foretinib on Matrix Metalloproteinase-2 (MMP2) Expression in Glioblastoma
Authors: Fotoohi Maryam , Hadi Nasrin , Namazi Faezeh 
Published: July 2019

Background: The most malignant form of infiltrating astrocytoma, glioblastoma multiforme (GBM), is one of the most aggressive human cancers. Foretinib diminished GBM cell invasion by downregulating the expression of matrix metalloproteinase 2 (MMP2).
Aim: The study aimed to examine the anti-tumor activity of foretinib and to test its effect on MMP2 expression in T98 cells.
Materials and Methods: T98 cells were used as an experimental model of glioblastoma. The effect of foretinib on the expression of MMP2 was evaluated using quantitative real-time polymerase chain reaction. Thereafter, the effect of foretinib on the enzyme levels of MMP was examined by zymography. Statistical analyses were performed with GraphPad Prism software.
Results: A reduction in the expression of MMP2 was observed with an increase in the concentration of foretinib.
Conclusion: Foretinib treatment leads to downregulation of MMP-2 and has a positive effect on T98 cells. We believe that foretinib can be subjected to further clinical investigation to develop a treatment for GBM.
British Council, Köy Enstitüleri ve Savaş Ortamında Kültürel Diplomasinin Yollarını Aramak
Authors: BABAOĞLU Resul 
Published: July 2019

Türkiye’de Cumhuriyet’in ilandan sonra siyasal alandaki devrimlere hız
verilmesiyle çağdaş bir devlet yapısı oluşturulmak istenmiş, girişilen radikal
reformlarla yalnızca idari modernleşme hedeflenmemiş, bunun yanında toplumsal yapının
da dönüştürülmesi için önemli adımlar atılmıştır. Ancak, siyasal alanda umulan değişimin
kısa sürede elde edilmesinden farklı olarak, Osmanlı’dan devralınan katılaşmış
ve geri plana itilmiş insan sermayesini dönüştürmek bilindiği gibi kolay
olmamıştır. Her şeyden önce, şehir merkezlerinde toplulaşmış okur-yazar kesimin
genel nüfusa göre oldukça düşük bir oranı teşkil etmesi, Cumhuriyet
idarecilerinin yüz yüze kaldıkları ciddi bir sorundur. Öte yandan 1928 yılında
Latin harflerinin kabulünden sonra vatandaşların eğitilmesi meselesi dönemin temel
gündem maddelerinden birini oluşturmuştur. Bilindiği gibi, toplumsal
kalkınmanın temel dinamiklerinden biri olan nitelikli insan sermayesinin elde
edilmesi için Cumhuriyet’in ilk yıllarında yoğun çabalar sarf edilmiştir. Bu
doğrultuda 17 Nisan 1940 tarihinde kabul edilen 3803 sayılı Köy Enstitüleri Kanunu
ile okul ve öğretmenden yoksun bölgelere ulaşılmaya çalışılarak taşranın eğitim
ihtiyacına cevap verilmeye çalışılmıştır. Köy Enstitüleri ile ilgili genel
kabulün aksine bu sistemle yalnızca öğretmen değil, aynı zamanda teknisyen,
sağlık personeli ve modern tarım tekniklerinden haberdar eğitimli yeni bir
insan profili yetiştirilmeye çalışılmıştır. Köy Enstitüleri’nin 1940’ların
sonlarından itibaren, bir dönüşüm sürecine girildiği bilinmekle birlikte, bu
enstitülerin Anadolu aydınlanmasının özgün bir örneği olduğu gerçeği göz önünde
tutulmalıdır. Nitekim bahse konu olan dönemde Türkiye’de faaliyet gösteren
British Council yetkililerinin Londra’daki merkez büroyla yazışmalarına konu
olan Köy Enstitüleri özgün ve dikkat çekici ölçüde başarılı bulunmuştur.
Dahası, British Council yetkililerinin girişimleriyle Köy Enstitüleri ve
İngiltere’de benzer faaliyetler yürüten Young Farmers Club arasında eğitim
temelinde işbirliği kurulması için çalışılmıştır. Hatta o dönem için radikal
sayılabilecek öğrenci değişim programı gibi uygulamalar için de British Council
yetkilileri Köy Enstitüleriyle işbirliği olanağı yaratmaya çalışmışlardır. Bu
çalışmada incelenen British Council evrakından yola çıkılarak Cumhuriyet döneminde
girişilen reformlar arasında günün şartlarından doğmuş, özgün bir uygulama olan
Köy Enstitülerine farklı bir pencereden ışık tutulmaya çalışılmıştır.&nbsp;&nbsp;
İngiliz Doğu Hindistan Şirketi’nin Yerli Birlikleri: Sepoy Ayaklanması
Authors: KÜLÜNK Furkan 
Published: July 2019

17.
yüzyılın hemen başında uzun soluklu Hindistan serüvenine başlayan İngiltere
menşeli Doğu Hindistan Şirketi, bu topraklarda kalıcı olmak istiyordu. Bu
doğrultuda bölgeye gelen devletlerin aksine öncelikli olarak daha ılımlı ve
kalıcı ticari ilişkilere yönelen şirket kısa zamanda Babürlü sarayında bir etkinlik
sahası tesis etti. Sahip olduğu etkinliği ve beraberindeki kazanımlarını koruma
zorunluluğu doğduğundan askeri yapılanma politikası gütmeye başladı. Özellikle
ticari merkezlerin korunması konusunda hassas bir politika güden şirket, İngiliz
askerlerin yanında yine İngiliz subayların emri altında olmak üzere asker
ihtiyacını yerli halktan karşılamaya başladı. Başlarda var olan yüksek sadakat
yerini bağımsızlık dürtülerinden beslenen ayaklanmaya bıraktı. İngiliz Doğu
Hindistan Şirketi’nin yetiştirdiği askerler şimdi İngilizlere karşı duruyorlardı.
Birçok sebebin sonucunda yardımcı birlikten isyancı asi ordusuna dönüşen
Sepoylar işte bu noktada Hindistan tarihinde bağımsızlık hareketinin öncüleri
olarak anılacaklardı. Bu çalışma, Sepoyların İngiliz Doğu Hindistan Şirketi
ordusunun bünyesine nasıl dahil olduklarından bahsedecek ve sonrasında hangi
nedenlerden dolayı bir ayaklanma başlattıkları üzerinde duracaktır.&nbsp;
Bolşeviklerin Geçici Hükümeti Devirme Girişimi: 1917 Temmuz Ayaklanması
Authors: SADIGOV Ramin 
Published: July 2019

1917 yılı Rusya için çalkantılı bir yıl oldu. Ülkede
art arda gelişen olaylar Çarlık rejimini yıkılmaya kadar götürdü. Yönetimi Geçici
bir hükümet devraldı, lakin onun icraatları devrimi yapan örgütleri pek memnun
etmedi. Özellikle Bolşevik Partisi ilk günden itibaren hükümetle uzlaşmayarak
ona karşı faaliyetlerde bulundu. Dahası diğer partileri de hükümetle iş
yapmakla suçlayarak Temmuz ayında bir ayaklanma girişimi yaptı, lakin başarısız
oldu. Türkiye’de Bolşeviklerin faaliyeti üzerine yapılan çalışmalarda
genellikle Ekim Devrimi üzerinde durulmaktadır. Bunun nedeni Ekim ayındaki
devrimi başarıyla sona erdirmiş olmalarıdır. Fakat onların Ekim’den önce de bir
ayaklanma girişiminde bulundukları ve hükümeti devirmek istedikleri bilinmektedir.
Yalnız bu hususun çalışmalarda pek yer almadığı tespit edilmiştir. Bundan
dolayı çalışmada Bolşeviklerin Temmuz’daki ayaklanma girişimi incelenmiş, nasıl
hazırlandıkları ve taraftarlarını ne denli organize ettikleri üzerinde
durulmuştur. Çalışma esnasında dönemin resmi ve gayri resmi basını, ilk dönem
Sovyet kaynakları ve son dönem araştırmaları üzerinden Bolşeviklerin ayaklanma
girişimindeki rolü tetkik edilmiştir.&nbsp;