bluuebunny/crossref_metadata_2025_split huggingface dataset:
Primary care in Germany: access and utilisation—a cross-sectional study with data from the German Socio-Economic Panel (SOEP)
Authors: Greiner Gregory Gordon , Schwettmann Lars , Goebel Jan , Maier Werner 
Published: October 2018

Objectives(1) To describe the accessibility of general practitioners (GPs) by the German population; (2) to determine factors on individual and area level, such as settlement structure and area deprivation, which are associated with the walking distance to a GP; and (3) to identify factors that may cause differences in the utilisation of any doctors.DesignCross-sectional study using individual survey data from the representative German Socio-Economic Panel (SOEP) linked with area deprivation data from the German Index of Multiple Deprivation for 2010 (GIMD 2010) and official data for settlement structure (urban/rural areas) at district level. Logistic regression models were estimated to determine the relationship of individual and area factors with the distance to a GP. Negative binomial regressions were used to analyse the association with utilisation.SettingGermany.Populationn=20 601 respondents from the SOEP survey data 2009.Primary outcome measureWalking distance to a GP.Secondary outcome measureDoctor visits.ResultsNearly 70% of the sample lives within a 20 min walk to a GP. People living in the most deprived areas have a 1.4-fold (95% CI 1.3 to 1.6) increased probability of a greater walking distance compared with the least deprived quintile, even after controlling for settlement structure and individual factors. In rural districts, people have a 3.1-fold (95% CI 2.8 to 3.4) higher probability of a greater walking distance compared with those in cities. Both area deprivation and rurality have a negative relationship with the utilisation of physicians, whereas the distance to a GP is not associated with the utilisation of physicians.ConclusionWalking distance to a GP depends on individual and area factors. In Germany, area deprivation is negatively correlated with the accessibility of GPs while controlling for settlement structure and individual factors. Both area factors are negatively associated with the utilisation of doctors. This knowledge could be used for future GP requirement plans.
ACL injury incidence, severity and patterns in professional male soccer players in a Middle Eastern league
Authors: Rekik Raouf Nader , Tabben Montassar , Eirale Cristiano , Landreau Philippe , Bouras Rachid , Wilson Mathew G , Gillogly Scott , Bahr Roald , Chamari Karim 
Published: October 2018

AimTo ascertain ACL injury incidence, severity (injury burden) and patterns (contact/non-contact and reinjuries) in a professional male football league in the Middle East over five consecutive seasons.MethodsProspective epidemiological study reporting ACL injuries in professional male soccer players in the Qatar Stars League, with complete matches/training exposure over five seasons (2013–2014 to 2017–2018), corresponding to 2243 player seasons and 729 team months.Results37 complete ACL ruptures occurred in 37 players during 486 951  hours of player exposure. The overall ACL injury rate was 0.076 injuries/1000  hours of exposure (season range 0.045–0.098). Injury incidence during matches and training was 0.41 and 0.04 injuries/1000  hours of exposure, respectively. Match injury incidence was greater than that of training (OR 11.8, 95%  CI 6.21 to 23.23, p<0.001). Average injury-related time-loss following ACL injury was 225 days±65 (range 116–360). Overall injury burden was 16.3 days lost/1000  hours of exposure.ConclusionThe overall ACL injury rate in professional male soccer players competing in the Middle East was 0.076 injuries/1000  hours of exposure, match injury incidence was greater than training, while the average ACL time-loss was 225 days.
Facilitating treatment of HCV in primary care in regional Australia: closing the access gap
Authors: White Lauren , Azzam Ali , Burrage Lauren , Orme Clare , Kay Barbara , Higgins Sarah , Kaye Simone , Sloss Andrew , Broom Jennifer , Weston Nicola , Mitchell Jonathan , O’Beirne James 
Published: October 2018

BackgroundAustralia has unrestricted access to direct-acting antivirals (DAA) for hepatitis C virus (HCV) treatment. In order to increase access to treatment, primary care providers are able to prescribe DAA after fibrosis assessment and specialist consultation. Transient elastography (TE) is recommended prior to commencement of HCV treatment; however, TE is rarely available outside secondary care centres in Australia and therefore a requirement for TE could represent a barrier to access to HCV treatment in primary care.ObjectivesIn order to bridge this access gap, we developed a community-based TE service across the Sunshine Coast and Wide Bay areas of Queensland.DesignRetrospective analysis of a prospectively recorded HCV treatment database.InterventionsA nurse-led service equipped with two mobile Fibroscan units assesses patients in eight locations across regional Queensland. Patients are referred into the service via primary care and undergo nurse-led TE at a location convenient to the patient. Patients are discussed at a weekly multidisciplinary team meeting and a treatment recommendation made to the referring GP. Treatment is initiated and monitored in primary care. Patients with cirrhosis are offered follow-up in secondary care.Results327 patients have undergone assessment and commenced treatment in primary care. Median age 48 years (IQR 38–56), 66% male. 57% genotype 1, 40% genotype 3; 82% treatment naïve; 10% had cirrhosis (liver stiffness >12.5 kPa). The majority were treated with sofosbuvir-based regimens. 26% treated with 8-week regimens. All patients had treatment prescribed and monitored in primary care. Telephone follow-up to confirm sustained virological response (SVR) was performed by clinic nurses. 147 patients remain on treatment. 180 patients have completed treatment. SVR data were not available for 19 patients (lost to follow-up). Intention-to-treat SVR rate was 85.5%. In patients with complete data SVR rate was 95.6%.ConclusionCommunity-based TE assessment facilitates access to HCV treatment in primary care with excellent SVR rates.
Prion-related peripheral neuropathy in sporadic Creutzfeldt-Jakob disease
Authors: Baiardi Simone , Redaelli Veronica , Ripellino Paolo , Rossi Marcello , Franceschini Alessia , Moggio Maurizio , Sola Patrizia , Ladogana Anna , Fociani Paolo , Magherini Anna , Capellari Sabina , Giese Armin , Caughey Byron , Caroppo Paola , Parchi Piero 
Published: October 2018

ObjectiveTo assess whether the involvement of the peripheral nervous system (PNS) belongs to the phenotypic spectrum of sporadic Creutzfeldt-Jakob disease (sCJD).MethodsWe examined medical records of 117 sCJDVV2 (ataxic type), 65 sCJDMV2K (kuru-plaque type) and 121 sCJDMM(V)1 (myoclonic type) subjects for clinical symptoms, objective signs and neurophysiological data. We reviewed two diagnostic nerve biopsies and looked for abnormal prion protein (PrPSc) by western blotting and real-time quaking-induced conversion (RT-QuIC) in postmortem PNS samples from 14 subjects.ResultsSeventy-five (41.2%) VV2-MV2K patients, but only 11 (9.1%) MM(V)1, had symptoms or signs suggestive of PNS involvement occurring at onset in 18 cases (17 VV2-MV2K, 9.3%; and 1 MM(V)1, 0.8%) and isolated in 6. Nerve biopsy showed a mixed predominantly axonal and demyelinating neuropathy in two sCJDMV2K. Electromyography showed signs of neuropathy in half of the examined VV2-MV2K patients. Prion RT-QuIC was positive in all CJD PNS samples, whereas western blotting detected PrPScin the sciatic nerve in one VV2 and one MV2K.ConclusionsPeripheral neuropathy, likely related to PrPScdeposition, belongs to the phenotypic spectrum of sCJDMV2K and VV2 and may mark the clinical onset. The significantly lower prevalence of PNS involvement in typical sCJDMM(V)1 suggests that the PNS tropism of sCJD prions is strain dependent.
Parallelization of dynamic languages: synchronizing built-in collections
Authors: Daloze Benoit , Tal Arie , Marr Stefan , Mössenböck Hanspeter , Petrank Erez 
Published: October 2018

Dynamic programming languages such as Python and Ruby are widely used, and much effort is spent on making them efficient. One substantial research effort in this direction is the enabling of parallel code execution. While there has been significant progress, making dynamic collections efficient, scalable, and thread-safe is an open issue. Typical programs in dynamic languages use few but versatile collection types. Such collections are an important ingredient of dynamic environments, but are difficult to make safe, efficient, and scalable.
In this paper, we propose an approach for efficient and concurrent collections by gradually increasing synchronization levels according to the dynamic needs of each collection instance. Collections reachable only by a single thread have no synchronization, arrays accessed in bounds have minimal synchronization, and for the general case, we adopt the Layout Lock paradigm and extend its design with a lightweight version that fits the setting of dynamic languages. We apply our approach to Ruby's Array and Hash collections. Our experiments show that our approach has no overhead on single-threaded benchmarks, scales linearly for Array and Hash accesses, achieves the same scalability as Fortran and Java for classic parallel algorithms, and scales better than other Ruby implementations on Ruby workloads.
Finding code that explodes under symbolic evaluation
Authors: Bornholt James , Torlak Emina 
Published: October 2018

Solver-aided tools rely on symbolic evaluation to reduce programming tasks, such as verification and synthesis, to satisfiability queries. Many reusable symbolic evaluation engines are now available as part of solver-aided languages and frameworks, which have made it possible for a broad population of programmers to create and apply solver-aided tools to new domains. But to achieve results for real-world problems, programmers still need to write code that makes effective use of the underlying engine, and understand where their code needs careful design to elicit the best performance. This task is made difficult by the all-paths execution model of symbolic evaluators, which defies both human intuition and standard profiling techniques.
This paper presents symbolic profiling, a new approach to identifying and diagnosing performance bottlenecks in programs under symbolic evaluation. To help with diagnosis, we develop a catalog of common performance anti-patterns in solver-aided code. To locate these bottlenecks, we develop SymPro, a new profiling technique for symbolic evaluation. SymPro identifies bottlenecks by analyzing two implicit resources at the core of every symbolic evaluation engine: the symbolic heap and symbolic evaluation graph. These resources form a novel performance model of symbolic evaluation that is general (encompassing all forms of symbolic evaluation), explainable (providing programmers with a conceptual framework for understanding symbolic evaluation), and actionable (enabling precise localization of bottlenecks). Performant solver-aided code carefully manages the shape of these implicit structures; SymPro makes their evolution explicit to the programmer.
To evaluate SymPro, we implement profilers for the Rosette solver-aided language and the Jalangi program analysis framework. Applying SymPro to 15 published solver-aided tools, we discover 8 previously undiagnosed performance issues. Repairing these issues improves performance by orders of magnitude, and our patches were accepted by the tools' developers. We also conduct a small user study with Rosette programmers, finding that SymPro helps them both understand what the symbolic evaluator is doing and identify performance issues they could not otherwise locate.
Object-oriented recovery for non-volatile memory
Authors: Cohen Nachshon , Aksun David T. , Larus James R. 
Published: October 2018

New non-volatile memory (NVM) technologies enable direct, durable storage of data in an application's heap. Durable, randomly accessible memory facilitates the construction of applications that do not lose data at system shutdown or power failure. Existing NVM programming frameworks provide mechanisms to consistently capture a running application's state. They do not, however, fully support object-oriented languages or ensure that the persistent heap is consistent with the environment when the application is restarted.In this paper, we propose a new NVM language extension and runtime system that supports object-oriented NVM programming and avoids the pitfalls of prior approaches. At the heart of our technique is object reconstruction, which transparently restores and reconstructs a persistent object's state during program restart. It is implemented in NVMReconstruction, a Clang/LLVM extension and runtime library that provides: (i) transient fields in persistent objects, (ii) support for virtual functions and function pointers, (iii) direct representation of persistent pointers as virtual addresses, and (iv) type-specific reconstruction of a persistent object during program restart. In addition, NVMReconstruction supports updating an application's code, even if this causes objects to expand, by providing object migration. NVMReconstruction also can compact the persistent heap to reduce fragmentation. In experiments, we demonstrate the versatility and usability of object reconstruction and its low runtime performance cost.
Leto: verifying application-specific hardware fault tolerance with programmable execution models
Authors: Boston Brett , Gong Zoe , Carbin Michael 
Published: October 2018

Researchers have recently designed a number of application-specific fault tolerance mechanisms that enable applications to either be naturally resilient to errors or include additional detection and correction steps that can bring the overall execution of an application back into an envelope for which an acceptable execution is eventually guaranteed. A major challenge to building an application that leverages these mechanisms, however, is to verify that the implementation satisfies the basic invariants that these mechanisms require---given a model of how faults may manifest during the application's execution.
To this end we present Leto, an SMT-based automatic verification system that enables developers to verify their applications with respect to an execution model specification. Namely, Leto enables software and platform developers to programmatically specify the execution semantics of the underlying hardware system as well as verify assertions about the behavior of the application's resulting execution. In this paper, we present the Leto programming language and its corresponding verification system. We also demonstrate Leto on several applications that leverage application-specific fault tolerance
Intensity matters: effects of cadence and power output on corticospinal excitability during arm cycling are phase and muscle dependent
Authors: Lockyer E. J. , Benson R. J. , Hynes A. P. , Alcock L. R. , Spence A. J. , Button D. C. , Power K. E. 
Published: October 2018

The present study investigated the effects of cadence and power output on corticospinal excitability to the biceps (BB) and triceps brachii (TB) during arm cycling. Supraspinal and spinal excitability were assessed using transcranial magnetic stimulation (TMS) of the motor cortex and transmastoid electrical stimulation (TMES) of the corticospinal tract, respectively. Motor-evoked potentials (MEPs) elicited by TMS and cervicomedullary motor-evoked potentials (CMEPs) elicited by TMES were recorded at two positions during arm cycling corresponding to mid-elbow flexion and mid-elbow extension (i.e., 6 and 12 o’clock made relative to a clock face, respectively). Arm cycling was performed at combinations of two cadences (60 and 90 rpm) at three relative power outputs (20, 40, and 60% peak power output). At the 6 o’clock position, BB MEPs increased ~11.5% as cadence increased and up to ~57.2% as power output increased ( P < 0.05). In the TB, MEPs increased ~15.2% with cadence ( P = 0.013) but were not affected by power output, while CMEPs increased with cadence (~16.3%) and power output (up to ~19.1%, P < 0.05). At the 12 o’clock position, BB MEPs increased ~26.8% as cadence increased and up to ~96.1% as power output increased ( P < 0.05), while CMEPs decreased ~29.7% with cadence ( P = 0.013) and did not change with power output ( P = 0.851). In contrast, TB MEPs were not different with cadence or power output, while CMEPs increased ~12.8% with cadence and up to ~23.1% with power output ( P < 0.05). These data suggest that the “type” of intensity differentially modulates supraspinal and spinal excitability in a manner that is phase- and muscle dependent. NEW & NOTEWORTHY There is currently little information available on how changes in locomotor intensity influence excitability within the corticospinal pathway. This study investigated the effects of arm cycling intensity (i.e., alterations in cadence and power output) on corticospinal excitability projecting to the biceps and triceps brachii during arm cycling. We demonstrate that corticospinal excitability is modulated differentially by cadence and power output and that these modulations are dependent on the phase and the muscle examined.
Extraction without tooling around — The first comprehensive description of the foraging- and socio-ecology of wild Goffin’s cockatoos (Cacatua goffiniana)
Authors: O’Hara M. , Mioduszewska B. , Haryoko T. , Prawiradilaga D.M. , Huber L. , Auersperg A. 
Published: October 2018

Abstract
When tested under laboratory conditions, Goffin’s cockatoos (Cacatua goffiniana) demonstrate numerous sophisticated cognitive skills. Most importantly, this species has shown the ability to manufacture and use tools. However, little is known about the ecology of these cockatoos, endemic to the Tanimbar Islands in Indonesia. Here we provide first insights into the feeding- and socio-ecology of the wild Goffin’s cockatoos and propose potential links between their behaviour in natural settings and their advanced problem-solving capacities shown in captivity. Observational data suggests that Goffin’s cockatoos rely on a large variety of partially seasonal resources. Furthermore, several food types require different extraction techniques. These ecological and behavioural characteristics fall in line with current hypotheses regarding the evolution of complex cognition and innovativeness. We discuss how the efficiency of (extractive) foraging may preclude tool use in wild Goffin’s cockatoos, even though the corresponding cognitive and ecological prerequisites seem to be present.
Global Wind Speed and Wave Height Extremes Derived from Long-Duration Satellite Records
Authors: Takbash Alicia , Young Ian R. , Breivik Øyvind 
Published: October 2018

Abstract
The application of extreme-value analysis to long-duration (30 year) global altimeter and radiometer datasets is considered. In contrast to previous extreme-value analyses of satellite data, the dataset is sufficiently long to enable a peaks over threshold analysis to be undertaken. When applied to altimeter data for wind speed and significant wave height, this analysis produces values consistent with buoy validation data and previous numerical model reanalysis datasets. The spatial distributions produced are also consistent with the model reanalysis data. However, the altimeter data shows much greater finescale structure for wind speed, which is consistent with known tropical cyclone activity. The greater data density provided by radiometer measurements offers the potential to address altimeter undersampling. However, issues associated with the radiometer’s inability to measure wind speed in heavy rain events appears to create an unacceptable “fair weather” bias at extreme wind speeds. This renders the radiometer data of wind speed largely unusable for the investigation of wind speed extremes. The study also clearly demonstrates the limitations of the initial distribution method for extreme-value analysis, which is heavily biased by mean conditions.
Characteristics of the Marine Boundary Layer Jet over the South China Sea during the Early Summer Rainy Season of Taiwan
Authors: Tu Chuan-Chi , Chen Yi-Leng , Lin Pay-Liam , Du Yu 
Published: October 2018

Abstract
The marine boundary layer jets (MBLJs) over the northern South China Sea during the early summer rainy season over Taiwan are analyzed using 5-yr (2008–12) National Centers for Environmental Prediction Climate Forecast System Reanalysis data with a 6-h interval. The MBLJ is distinctly different from the low-level jets associated with the subsynoptic frontal systems. During this period, the MBLJ events over the northern South China Sea mainly occur during the second half of the monsoon rainy season over Taiwan (after 1 June) and have a wind speed maximum around the 925-hPa level. The MBLJs are mainly related to the subsynoptic-scale pressure gradients related to a relatively deep mei-yu trough over southeastern China and a stronger-than-normal west Pacific subtropical high. Within the MBL, there is a three-way balance among pressure gradients, Coriolis force, and surface friction, with cross-isobar ageostrophic winds pointing toward the mei-yu trough throughout the diurnal cycle. At the jet core, the vertical wind profile resembles an Ekman spiral with supergeostrophic winds &gt;12 m s−1 near the top of the MBL. The MBLJs are strongest at night and close to geostrophic flow in the late afternoon/early evening. This is because the friction velocity and ageostrophic wind decrease during daytime in response to mixing in the lowest levels. The MBLJs play an important role in horizontal moisture transport from the northern South China Sea to the Taiwan area. In the frontal zone, the moisture tongue extends vertically upward. The rainfall production is related to vertical motions in the frontal zone or localized lifting due to orographic effects.
Labor and Development in Twenty-first-Century Latin America: Two Political Options
Authors: Moisá Elicabide Laura Carla , Silverman Jana K. , Piñón Pereira Dias María 
Published: October 2018

An analysis of the results of social and labor policy in two Southern Cone countries (Uruguay and Brazil) and two members of the Pacific Alliance (Mexico and Colombia) between 2000 and 2012 focused on minimum wage policy, state intervention in labor market regulation and supervision, and relations between governments and social and political actors, especially unions, indicates that, in contrast to the situation in the progressive countries, the neoliberal policies adopted by Mexico and Colombia maintained social divisions instead of reducing them in this period. Un análisis de los resultados de la política social y laboral en dos países del Cono Sur (Uruguay y Brasil) y dos miembros de la Alianza del Pacífico (México y Colombia) entre 2000 y 2012 enfocado en la política de salario mínimo, intervención estatal en regulación y supervisión del mercado laboral, y las relaciones entre los gobiernos y los actores sociales y políticos, especialmente los sindicatos, indica que, a diferencia de la situación en los países progresistas, las políticas neoliberales adoptadas por México y Colombia mantuvieron las divisiones sociales en lugar de reducirlas en este período.