bluuebunny/crossref_metadata_2025_split huggingface dataset:
Uniportal video‐assisted thoracic surgery could reduce postoperative thorax drainage for lung cancer patients
Authors: Li Jiagen , Qiu Bin , Scarci Marco , Rocco Gaetano , Gao Shugeng 
Published: May 2019

BackgroundUniportal video‐assisted thoracic surgery (VATS) has undergone significant development in recent years, yet its usefulness and value in the treatment of lung cancer remains controversial. We investigated the effect of uniportal VATS surgery for reducing postoperative thorax drainage in lung cancer patients.MethodsThe data of primary lung cancer patients who underwent VATS anatomical lung resection at the China National Cancer Center by a single surgeon were retrospectively collected. After propensity score matched analysis, 492 patients (246 uniportal VATS, 246 multiportal VATS) were included in the study. The clinicopathologic and surgery‐related features, including drainage volume, were compared. Student's t and chi‐square tests were used; all tests were two‐sided.ResultsPatients in the two groups had similar demographic and clinicopathological features. Patients who underwent uniportal VATS surgery had significantly lower postoperative thorax drainage (830.0 ± 666.0 mL vs. 1014.5 ± 616.9 mL, P = 0.002) and a comparatively lower rate of unplanned return to the operating room (0 vs. 0.8%; P = 0.156) than multiportal VATS patients. The surgical duration, blood loss, number of lymph nodes dissected, postoperative complications, and length of hospital stay were similar between the groups.ConclusionsUniportal VATS could reduce postoperative thorax drainage and the risk of unplanned return to the operating room for lung cancer patients. This study included the largest sample by a single surgeon and our results suggest the potential value of uniportal VATS for the faster recovery of lung cancer patients.
Predictors of survival in non‐small cell lung cancer patients with pleural effusion undergoing thoracoscopy
Authors: Xie Li‐Xu , Wang Xing‐Guang , You Wen‐Jie , Ma Xiao‐Bin , Wang Yong‐Gang , Liu Ting‐Ting , Jiang Shu‐Juan 
Published: May 2019

BackgroundMalignant pleural effusion (MPE) predicts advanced disease and poor prognosis, and is usually diagnosed by medical thoracoscopy. It remains unclear whether the various representations visualized on thoracoscopy are reliable prognostic factors. The aim of this study was to evaluate prognostic factors for survival in patients who underwent thoracoscopy for MPE.MethodsThe medical records of consecutive patients with MPE who underwent medical thoracoscopy from 2007 to 2015 at a tertiary hospital were reviewed and theKaplan‐Meier method and Cox regression analysis used to determine prognostic factors.ResultsA total of 125 patients with non‐small cell lung cancer (NSCLC) were confirmed on tissue biopsy as having pleural metastasis. In NSCLC, factors adversely affecting overall survival (OS) in univariate analysis included extent of pleural carcinomatosis (EPC) score (P = 0.031), grade of adhesions (P = 0.037), costoparietal pleural lesions (P = 0.035) and bloody MPE (P = 0.023); Cox multivariate analysis revealed that EPC score (P = 0.007) and grade of adhesions (P = 0.019) were independent predictors of OS.ConclusionsUnder traditional chemotherapy, higher EPC score and higher grades of adhesions predicted poor prognosis in advanced NSCLC patients with pleural metastasis. Taking into account these factors may allow doctors to make more accurate predictions and provide individual therapy when treating patients with MPE.
Interaction of Alt a 1 with SLC22A17 in the airway mucosa
Authors: Garrido‐Arandia María , Tome‐Amat Jaime , Pazos‐Castro Diego , Esteban Vanesa , Escribese Maria M. , Hernández‐Ramírez Guadalupe , Yuste‐Montalvo Alma , Barber Domingo , Pacios Luis F. , Díaz‐Perales Araceli 
Published: May 2019

AbstractBackgroundDespite all the efforts made up to now, the reasons that facilitate a protein becoming an allergen have not been elucidated yet. Alt a 1 protein is the major fungal allergen responsible for chronic asthma, but little is known about its immunological activity. Our main purpose was to investigate the ligand‐dependent interactions of Alt a 1 in the human airway epithelium.MethodsAlt a 1 with and without its ligand (holo‐ and apo‐ forms) was incubated with the pulmonary epithelial monolayer model, Calu‐3 cells. Allergen transport and cytokine production were measured. Pull‐down and immunofluorescence assays were employed to identify the receptor of Alt a 1 using the epithelial cell model and mouse tissues. Receptor‐allergen‐ligand interactions were analyzed by computational modeling.ResultsThe holo‐form could activate human monocytes, PBMCs, and polarized airway epithelial (Calu‐3) cell lines. The allergen was also transported through the monolayer, without any alteration of the epithelial integrity (TEER). Alt a 1 also induced the production of proinflammatory IL8 and specific epithelial cytokines (IL33 and IL25) by Calu‐3 cells. The interaction between epithelial cells and holo‐Alt a 1 was found to be mediated by the SLC22A17 receptor, and its recognition of Alt a 1 was explained in structural terms.ConclusionsOur findings identified the Alt a 1 ligand as a central player in the interaction of the allergen with airway mucosa, shedding light into its potential role in the immunological response, while unveiling its potential as a new target for therapy intervention.
Collaborative filmmaking and affective traces of belonging
Authors: Vasudevan Lalitha , Riina‐Ferrie Joseph 
Published: May 2019

AbstractIn order to explore how experiences with youth media production resonate with people throughout their lives, we conducted video interviews with alumni from the Educational Video Center's youth documentary programs across the organization's history of more than 30 years. We talked with alumni and watched their films together to see what memories and feelings they would share through revisiting their filmmaking. We devised a multimodal analysis method that places the films alongside the interview footage in order to observe how affect was embodied by the alumni, as well as their use of affect to reflect on their filmmaking experiences. Affective moments gave us clues about how to understand and situate the memories as lingering traces of alumni's past experiences, that centered on descriptions of belonging.
Supporting collaborative learning using a diagram‐based visible thinking tool based on cognitive load theory
Authors: Cai Huiying , Gu Xiaoqing 
Published: May 2019

AbstractA natural concern in the field of computer‐supported collaborative learning is how participants in collaborative learning project attain individual deep understanding through pedagogical or technological support. This study explores such individual outcomes as influenced by designing a collaborative learning project supported with a diagram‐based thinking tool based on cognitive load theory (CLT). A comparative experiment was designed to evaluate the effectiveness of the diagram‐based thinking tool. A total of 49 first‐year graduate students were recruited and assigned to two conditions. In the experiment condition, the group students completed the collaborative learning project through a diagram‐based thinking tool, while the group students in the control condition completed the same project through an alternative text‐based thinking tool. Pre‐and posttesting of the domain knowledge was employed to evaluate each individual's learning outcome. Group discourse was employed to evaluate how group students actively engage during collaboration. Results show that the support of diagram‐based thinking tool integrated in collaborative learning can facilitate individual understanding intensively. Moreover, diagram‐based thinking tool can engage group students into cognitively demanding learning activities actively. Findings demonstrate that the semantic diagram tool provides promising technological support when designing collaborative learning project based on CLT. This study serves as a foundation to the design of technological support for future classroom‐based collaborative learning project.
Practitioner NotesWhat is already known about this topic

According to cognitive load theory, the construction of shared knowledge and also the benefit of communication and coordination during social interaction should be optimized when design the collaborative learning.
To help learners benefit from social interaction during collaborative learning project, technological support should be carefully designed.
External representations have been recognized as one kind of suitable technological affordance for learners’ cognitive and social development.
What this paper adds

The diagram‐based visible thinking tool with conceptual and socio‐cognitive support integrated in collaborative learning can facilitate individual understanding intensively.
The diagram‐based thinking tool with conceptual and socio‐cognitive support can actively engage group students into cognitively demanding learning activities.
Implications for practice and/or policy

The idea of semantic diagram tool with conceptual and socio‐cognitive support is suitable technological support for effective collaborative learning from the perspective of cognitive load theory.
The idea of semantic diagram tool with conceptual and socio‐cognitive support provide teachers with more understandable guidance to design and conduct the collaborative learning project in the classroom.
Understanding What Has Been Happening to the Public‐Sector Pay Premium in Great Britain: A Distributional Approach Based on the Labour Force Survey
Authors: Murphy Philip , Blackaby David , O'Leary Nigel , Staneva Anita 
Published: May 2019

AbstractThis article investigates what has been happening to the public‐sector wage differential in Great Britain over the period 1994–2017. The evidence indicates that apart from men in the lower part of the pay distribution, the public‐sector pay premium has declined for all public‐sector workers. This decline has coincided with a decline in the overall pay gap, which is associated with changes in the composition of public‐ and private‐sector workforces. As the relative pay disadvantage experienced by public‐sector workers at the top of the pay distribution has worsened over time this must raise serious concerns about the ability of the public sector to recruit and retain the staff it needs to deliver public services.
Sex differences in the hypothalamic–pituitary–adrenal axis: An obstacle to antidepressant drug development?
Authors: Kokras Nikolaos , Hodes Georgia E. , Bangasser Debra A. , Dalla Christina 
Published: May 2019

Hypothalamic–pituitary–adrenal (HPA) axis dysfunction has long been implicated in the pathophysiology of depression, and HPA axis‐based compounds have served as potential new therapeutic targets, but with no success. This review details sex differences from animal and human studies in the function of HPA axis elements (glucocorticoids, corticotropin releasing factor, and vasopressin) and related compounds tested as candidate antidepressants. We propose that sex differences contribute to the failure of novel HPA axis‐based drugs in clinical trials. Compounds studied preclinically in males were tested in clinical trials that recruited more, if not exclusively, women, and did not control, but rather adjusted, for potential sex differences. Indeed, clinical trials of antidepressants are usually not stratified by sex or other important factors, although preclinical and epidemiological data support such stratification. In conclusion, we suggest that clinical testing of HPA axis‐related compounds creates an opportunity for targeted, personalized antidepressant treatments based on sex.LINKED ARTICLESThis article is part of a themed section on The Importance of Sex Differences in Pharmacology Research. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v176.21/issuetoc
Procognitive impact of ciproxifan (a histaminergic H3 receptor antagonist) on contextual memory retrieval after acute stress
Authors: Chauveau Frédéric , De Job Elodie , Poly‐Thomasson Betty , Cavroy Raphaël , Thomasson Julien , Fromage Dominique , Beracochea Daniel 
Published: May 2019

SummaryAimAlthough cognitive deficits commonly co‐occur with stress‐related emotional disorders, effect of procognitive drugs such as histaminergic H3 receptor antagonists are scarcely studied on memory retrieval in stress condition.MethodsExperiment 1. Memory of two successive spatial discriminations (D1 then D2) 24 hours after learning was studied in a four‐hole board in mice. H3 receptor antagonist ciproxifan (ip 3 mg/kg) and acute stress (three electric footshocks; 0.9 mA; 15 ms) were administered 30 and 15 minutes respectively before memory retrieval test. Fos immunostaining was performed to evaluate the neural activity of several brain areas. Experiment 2. Effects of ciproxifan and acute stress were evaluated on anxiety‐like behavior in the elevated plus maze and glucocorticoid activity using plasma corticosterone assay.ResultsExperiment 1. Ciproxifan increased memory retrieval of D2 in nonstress condition and of D1 in stress one. Ciproxifan mitigated the stress‐induced increase of Fos expression in the prelimbic and infralimbic cortex, the central and basolateral amygdala and the CA1 of dorsal hippocampus. Experiment 2. Ciproxifan dampened the stress‐induced anxiety‐like behavior and plasma corticosterone increase.ConclusionCiproxifan improved contextual memory retrieval both in stress and nonstress conditions without exacerbating behavioral and endocrine responses to stress. Overall, these data suggest potential usefulness of H3 receptor antagonists as cognitive enhancer both in nonstress and stress conditions.
Female sexual problems after treatment for colorectal cancer – a population‐based study
Authors: Thyø A. , Elfeki H. , Laurberg S. , Emmertsen K. J. 
Published: May 2019

AbstractAimThere has been limited focus on female sexuality after treatment for colorectal cancer. The aim of this study was to investigate long‐term female sexual dysfunction in disease‐free colorectal cancer survivors in the Danish population.MethodAll female Danish patients treated for colorectal cancer between 2001 and 2014 were included if they reported to have been sexually active at the time of diagnosis. They were requested to answer the validated Sexual Vaginal Changes Questionnaire.ResultsA total of 2402 patients were included for analysis (43%). Overall, rectal cancer patients reported more sexual inactivity and problems compared to colon cancer patients, but there were no differences in any sexual function domains when excluding irradiated patients and patients with a permanent stoma. A permanent stoma was associated with sexual inactivity [OR 2.56 (95% CI 1.42–4.70)] and overall sexual dysfunction [OR 2.95 (95% CI 1.05–6.38)] in colon cancer patients, as well as inactivity [OR 1.43 (95% CI 1.01–2.04)] and overall dysfunction [OR 2.0 (95% CI 1.18–3.41)] in rectal cancer patients. Furthermore, a permanent stoma was associated with dyspareunia [OR 2.17 (95% CI 1.39–3.38)] and reduced vaginal dimension [OR 3.16 (95% CI 1.99–5.01)]. In rectal cancer patients, radiotherapy exposure increased the odds for overall sexual dysfunction [OR 1.80 (95% CI 1.02–3.16)] and was associated with dyspareunia [OR 1.72 (95% CI 0.95–3.12)].ConclusionSexual problems after treatment of colorectal cancer are common. Major risk factors are a permanent stoma and radiotherapy. Relevant patients should be offered professional counselling and treatment.
Golgi phosphoprotein 3 sensitizes the tumour suppression effect of gefitinib on gliomas
Authors: Wang Xu , Wang Zhaohao , Zhang Yu , Wang Yan , Zhang Hao , Xie Shao , Xie Peng , Yu Rutong , Zhou Xiuping 
Published: May 2019

AbstractObjectivesWe previously reported that Golgi phosphoprotein 3 (GOLPH3) promotes glioma progression by inhibiting EGFR endocytosis and degradation, leading to EGFR accumulation and PI3K‐AKT pathway over‐activation. In the current study, we examine whether GOLPH3 affects the response of glioma cells to gefitinib, an EGFR selective inhibitor.Materials and MethodsThe expression of GOLPH3 and EGFR in glioma cells was detected by immunofluorescence and immunoblotting. The cell viability or growth in vitro was determined by CCK‐8, EdU incorporation and clonogenic assays. The primary glioma cells were cultured by trypsin and mechanical digestion. The transwell invasion assay was used to examine the primary glioma cell motility. Intracranial glioma model in nude mice were established to explore the sensitivity of gefitinib to GOLPH3 high cancer cells in vivo.ResultsBoth the immortalized and primary glioma cells with GOLPH3 over‐expression hold higher EGFR protein levels on the cell membrane and exhibited higher sensitivity to gefitinib. In addition, primary glioma cells with higher GOLPH3 level exhibited stronger proliferation behaviour. Importantly, GOLPH3 enhanced the anti‐tumour effect of gefitinib in vivo. Consistently, after gefitinib treatment, tumours derived from GOLPH3 over‐expression cells exhibited lower Ki67‐positive and higher cleaved caspase‐3–positive cells than control tumours.ConclusionsOur results demonstrate that GOLPH3 increases the sensitivity of glioma cells to gefitinib. Our study provides foundation for further exploring whether GOLPH3 high gliomas will be more sensitive to anti‐EGFR therapy in clinic and give ideas for developing new possible treatments for individual glioma patients.
Congenital cutaneous pyogenic granuloma: Report of two cases and review of the literature
Authors: Schneider Mateus Henrique , Garcia Camila Foletto Vargas , Aleixo Pedro Bandeira , Kiszewski Ana Elisa 
Published: May 2019

AbstractCongenital cutaneous pyogenic granuloma is a rare benign vascular tumor with clinical and histopathological features similar to infantile hemangioma. It usually presents as a red, pedunculated and highly friable papule. On histopathological analysis, one can see a capillary vessel proliferation with lobular pattern and endothelial proliferation. The differential diagnosis is based on negativity of glucose transporter 1 (GLUT1) immunochemistry studies. We report two infants with congenital pyogenic granuloma, one with a unique cutaneous lesion and the other with multiple lesions affecting both skin and mucosal surfaces. These two cases highlight the importance of the differential diagnosis based on the GLUT1 immunochemistry analysis considering the distinct treatments required to these infant vascular tumors.
A case of extramedullary hematopoiesis presenting as hemorrhagic panniculitis and evolving in acute myeloid leukemia
Authors: Gallo Graziana , Bigliardi Sara , Cesinaro Anna Maria 
Published: May 2019

AbstractExtramedullary hematopoiesis (EMH) in adults is a rare event, usually associated with myeloid disorders, and can be the first sign of chronic myelomonocytic leukemia. We report a case of EMH presenting as a hemorrhagic panniculitis in a patient who did not apparently present any myeloid disorders. The patient received previous chemotherapy for mantle cell lymphoma localized to the large bowel and had been in complete remission for 3 years. The diagnosis of EMH was achieved after a deep incisional biopsy of a nodule from the thigh, and with pathological examination that included immunohistochemical studies. After a follow‐up of 14 months, the patient developed an acute myeloid leukemia, classified as therapy‐related myeloid neoplasm, according to the 2016 World Health Organization (WHO) classification of hematological malignancies. As shown by the rare cases described in literature, the presence of cutaneous EMH should always be a trigger for investigating the patient's hematological system; also, in our experience, a long follow‐up is mandatory.
Plasmacytic cutaneous pathology: A review
Authors: Walsh Noreen M. , Kutzner Heinz , Requena Luis , Cerroni Lorenzo 
Published: May 2019

AbstractWe review the spectrum of cutaneous disorders associated with inflammatory and neoplastic plasmacytic pathology. Because plasma cells are derived from B‐lymphocytes our overview includes discussion of certain lymphoplasmacytic proliferations. It is structured along histopathological lines, addressing conditions characterized by (a) cutaneous plasma cell infiltrates, (b) deposits of plasma cell products or their derivatives in the skin and (c) miscellaneous, poorly understood cutaneous complications of plasmacytic disorders. Lesions arising primarily in the skin and those due to cutaneous involvement by multisystem disorders are addressed. The range includes a spectrum of tumefactive and circulatory manifestations. We highlight key clinical and pathological features of the different conditions and outline recent advances in our understanding of these entities. By emphasizing the dermatopathological characteristics of this spectrum of disorders we hope to hone the diagnostic accuracy of practitioners in the field.
The Golden Proportion in the scallop geometry of normal mitral valves. When nature plays with jigsaw puzzles
Authors: Deorsola Luca , Bellone Alessandra 
Published: May 2019

AbstractIntroductionThe Golden Proportion is a particular geometric ratio between two segments. It results in an irrational number, commonly rounded to 1.618, or 0.618, and showing unique geometrical/mathematical properties. Its presence has been documented in a huge amount of natural settings, as well as the human body and the heart. In light of a previous research of ours, about its presence in the Coaptation Triangle, we investigated the dimensions of both mitral leaflets in healthy mitral valves and then compared our results to literature data, in order to search whether this proportional pattern could be extended to other valve aspects.Methods and ResultsForty‐one adults, with healthy mitral valves, underwent 2D echocardiography. Adequate long‐axis three‐chamber view images were chosen, at mid‐diastole, where the central scallop of both the anterior and posterior leaflets (A2 and P2, respectively) could be well identified and measured. We then investigated these measurements, calculating their ratio and comparing our findings to literature data on normal mitral anatomy. The ratio between the two scallop heights appeared very close to the Golden Ratio. Literature data supported our results and, apparently, showed the mitral leaflets to be like a jigsaw puzzle of components highly interconnected each other with an extremely simple geometry, based on the Golden Proportion.ConclusionThe Golden Proportion looks to determine the geometry of normal mitral scallops. Studying such a pattern of anatomical proportions could improve surgical techniques for conservative surgery, as well as innovate the design of mitral repair rings and valve prostheses.