bluuebunny/crossref_metadata_2025_split huggingface dataset:
Operation Scheduling of Household Load, EV and BESS Using Real Time Pricing, Incentive Based DR and Peak Power Limiting Strategy
Authors: Kakran Sandeep , Chanana Saurabh 
Published: December 2018

Abstract
Demand response (DR) programs have become powerful tools of the smart grids, which provide opportunities for the end-use consumers to participate actively in the energy management programs. This paper investigates impact of different DR strategies in a home-energy management system having consumer with regular load, electric vehicle (EV) and battery-energy storage system (BESS) in the home. The EV is considered as a special type of load, which can also work as an electricity generation source by discharging the power in vehicle-to-home mode during high price time. BESS and a small renewable energy source in form of rooftop photovoltaic panels give a significant contribution in the energy management of the system. As the main contribution to the literature, a mixed integer linear programming based model of home energy management system is formulated to minimize the daily cost of electricity consumption under the effect of different DR programs; such as real time price based DR program, incentive based DR program and peak power limiting DR program. Finally, total electricity prices are analysed in the case studies by including different preferences of the household consumer under mentioned DR programs. A total of 26.93 % electricity cost reduction is noticed with respect to base case, without peak limiting DR and 19.93 % electricity cost reduction is noticed with respect to base case, with peak limiting DR.
Planning Method of Regional Integrated Energy System considering Demand Side Uncertainty
Authors: Ge Shaoyun , Liu Xiaoou , Ge Lukun 
Published: December 2018

Abstract
In this paper, a robust planning method of regional integrated energy system (IES) considering the uncertainty of cooling, heat and electrical loads on the demand side is submitted. First, the energy hub (EH) model of regional IES with Combined Cooling Heating and Power (CCHP), electric air-conditioning unit (EC) and gas boiler (GB) is established. Second, the uncertainty of load is described by the method of adjustable interval, and the robust planning model of regional IES is formed. Third, the robust programming model can be transformed into a convex mixed integer planning model, and then solved. Finally, the case study is carried out with a comprehensive area of Tianjin in China, the results are analyzed to verify the effectiveness of the proposed planning method.
The Lives of Pythagoras: A Proposal for Reading Pythagorean Metempsychosis
Authors: Pellò Caterina 
Published: December 2018

Abstract
According to Dicaearchus, metempsychosis was the best known among Pythagoras’ teachings. In this paper, I investigate two features of Pythagorean metempsychosis: its non-retributive character and its epistemological value. I argue that the Pythagoreans did not conceive of reincarnation as a punishment for the wicked and a reward for the virtuous, but rather as a way to gain experience, knowledge and therefore wisdom. This reading enables us to throw light on the puzzling list of Pythagoras’ past lives, which includes Aethalides son of Hermes, Euphorbus the warrior, Pyrrhus the fisherman and even Alco the harlot.
Über Wasserstoffaustauschkatalyse an oxydischen Kontakten
Authors: Eucken Arnold , Wicke Ewald 
Published: December 2018

Abstract
Es wird die Vorstellung entwickelt, daß sich bei der Spaltung von Alkoholen in Wasser und von Olefinen an oxydischen Kontakten (Bauxit und γ-Al203) oberflächliche Hydroxylgruppen der Kontaktsubstanz katalytisch betätigen. Die Wirksamkeit dieser Hydroxylgruppen beruht auf einem durch das "Prinzip der geringsten Strukturände-rung" ausgezeichneten Austauschmechanismus von H-Partikeln. Aus dieser Vorstellung ergibt sich eine Reihe von Folgerungen über den Einfluß der Besetzungsdichte der Oberfläche mit Hydroxylgruppen, über die durch den Austausch zu überbrückenden Atomabstände und über das Verhalten mit OD-Gruppen besetzter Kontaktoberflächen, die experimentell nachgeprüft und mit dem entworfenen Reaktionsmechanismus in Ein-klang gefunden werden.
Kristallchemie des In und Ga in Legierungen mit einigen Übergangselementen (Ni, Pd, Pt, Cu, Ag und Au)
Authors: Hellner Erwin , Laves Fritz 
Published: December 2018

Abstract
Zur Erweiterung der Kenntnis über das chemische Verhalten des Galliums und Indiums in Legierungen wurde eine größere Anzahl bislang unbekannter (20) Kristallstrukturen intermetallischer Phasen dieser Elemente mit Übergangselementen bestimmt. Unter den gefundenen Typen sind solche bevorzugt, die vom geometrischen Standpunkt aus (wegen der atomaren Abstandsverhältnisse) das Wirken heteropolarer Kräfte erkennen lassen. Die Ergebnisse bestätigen die Annahme heteropolarer Bindungstendenzen, die in diesen Systemen als Ausdruck eines elektronegativen Charakters von Gallium und Indium anzusehen sind.
Die Isotopenzusammensetzung und die Atomgewichte von Neodym, Samarium und Wolfram
Authors: Mattauch Josef , Scheld Hildegard 
Published: December 2018

Abstract
Nach der bereits von dem einen von uns mit H. Ewald gelegentlich der Untersuchung von Hafnium ausführlich beschriebenen photometrischen Methode, die zu einem schnell arbeitenden Routineverfahren ausgearbeitet worden war, wurden did Linienverhältnisse - das soll heißen die Verhältnisse der Häufigkeiten von Isotopen benachbarter Häufigkeit - beim Neodym, Samarium und Wolfram gemessen, und zwar mit zwei verschiedenen Eichelementen - Xenon und Zink - sowohl für die einfach wie für die doppelt geladenen Ionen. Aus den Mitteln der innerhalb der Fehler übereinstimmenden Wertereihen berechnen sich die folgenden Isotopenhäufigkeiten (Fehlerangaben in % derselben):
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ferner die mittleren Massenzahlen Nd : 144,346 ± 0,010, Sm : 150,508 ± 0,019, W : 183,893 ± 0,003 und (unter Annahme der Packungsanteile des „Isotopenberichtes 1942" und eines Umrechnungsfaktors 1,000275) die chemischen Atomgewichte Nd: 144,27x ± 0,01, Sm : 150,43 ± 0,01, W : 183,853 ± 0,01. Von diesen Werten steht der für Neodym in ausgezeichneter Übereinstimmung mit den neueren Atomgewichtsbestimmungen von Hönigschmid und Willner (1938) und von Baxter und Mitarbeitern (1911/16); der für Samarium stimmt vollkommen mit dem Wert der Harvard - Schule (1917/20) überein, während der Wert von Hönigschmid und Hirschbold - Wittner (1941) um etwa 0,3 bis 0,4 ‰ darunter liegt. Beim Wolfram liegt der massenspektrographische Wert ebenso wie bei dem homologen Molybdän fast 0,4 ‰ unter den chemischen Bestimmungen von Hönigschmid und Mitarbeitern (1936). Von zwei im Vorjahr veröffentlichten massenspektrometrischen Messungen der Isotopenhäufigkeiten von Wolfram stimmen die Werte von Williams und Yuster sehr gut mit den unseren überein, während die von Inghram kleine, aber systematische Abweichungen davon zeigen. Am Beispiel des Neodyms wird gezeigt, daß man mit Hilfe der Methode imstande ist, kleine Verunreinigungen durch andere Seltene Erden im Betrag von nur einigen Bruchteilen eines Promilles nachzuweisen und quantitativ zu schätzen.
A Needs Analysis of Karate Kumite With Recommendations for Performance Testing and Training
Authors: Chaabene Helmi , Negra Yassine , Capranica Laura , Prieske Olaf , Granacher Urs 
Published: December 2018

ABSTRACT
AN EFFECTIVE TRAINING PROGRAM NEEDS TO BE CUSTOMIZED TO THE SPECIFIC DEMANDS OF THE RESPECTIVE SPORT. THEREFORE, IT IS IMPORTANT TO CONDUCT A NEEDS ANALYSIS TO GAIN INFORMATION ON THE UNIQUE CHARACTERISTICS OF THE SPORT. THE OBJECTIVES OF THIS REVIEW WERE (A) TO CONDUCT A SYSTEMATIC NEEDS ANALYSIS OF KARATE KUMITE AND (B) TO PROVIDE PRACTICAL RECOMMENDATIONS FOR SPORT-SPECIFIC PERFORMANCE TESTING AND TRAINING OF KARATE KUMITE ATHLETES. FOR A VIDEO ABSTRACT OF THIS ARTICLE SEE SUPPLEMENTAL DIGITAL CONTENT 1, HTTP://LINKS.LWW.COM/SCJ/A248.
Input-Specific Synaptic Location and Function of the α5 GABAAReceptor Subunit in the Mouse CA1 Hippocampal Neurons
Authors: Magnin Elise , Francavilla Ruggiero , Amalyan Sona , Gervais Etienne , David Linda Suzanne , Luo Xiao , Topolnik Lisa 
Published: December 2018

Hippocampus-dependent learning processes are coordinated via a large diversity of GABAergic inhibitory mechanisms. The α5 subunit-containing GABAAreceptor (α5-GABAAR) is abundantly expressed in the hippocampus populating primarily the extrasynaptic domain of CA1 pyramidal cells, where it mediates tonic inhibitory conductance and may cause functional deficits in synaptic plasticity and hippocampus-dependent memory. However, little is known about synaptic expression of the α5-GABAAR and, accordingly, its location site-specific function. We examined the cell- and synapse-specific distribution of the α5-GABAAR in the CA1 stratum oriens/alveus (O/A) using a combination of immunohistochemistry, whole-cell patch-clamp recordings and optogenetic stimulation in hippocampal slices obtained from mice of either sex. In addition, the input-specific role of the α5-GABAAR in spatial learning and anxiety-related behavior was studied using behavioral testing and chemogenetic manipulations. We demonstrate that α5-GABAAR is preferentially targeted to the inhibitory synapses made by the vasoactive intestinal peptide (VIP)- and calretinin-positive terminals onto dendrites of somatostatin-expressing interneurons. In contrast, synapses made by the parvalbumin-positive inhibitory inputs to O/A interneurons showed no or little α5-GABAAR. Inhibiting the α5-GABAAR in control micein vivoimproved spatial learning but also induced anxiety-like behavior. Inhibiting the α5-GABAAR in mice with inactivated CA1 VIP input could still improve spatial learning and was not associated with anxiety. Together, these data indicate that the α5-GABAAR-mediated phasic inhibition via VIP input to interneurons plays a predominant role in the regulation of anxiety while the α5-GABAAR tonic inhibition via this subunit may control spatial learning.SIGNIFICANCE STATEMENTThe α5-GABAAR subunit exhibits high expression in the hippocampus, and regulates the induction of synaptic plasticity and the hippocampus-dependent mnemonic processes. In CA1 principal cells, this subunit occupies mostly extrasynaptic sites and mediates tonic inhibition. Here, we provide evidence that, in CA1 somatostatin-expressing interneurons, the α5-GABAAR subunit is targeted to synapses formed by the VIP- and calretinin-expressing inputs, and plays a specific role in the regulation of anxiety-like behavior.
Dendritic Spines in Early Postnatal Fragile X Mice Are Insensitive to Novel Sensory Experience
Authors: Arroyo Erica D. , Fiole Daniel , Mantri Shilpa S. , Huang Claire , Portera-Cailliau Carlos 
Published: December 2018

Autism spectrum disorders are often associated with atypical sensory processing and sensory hypersensitivity, which can lead to maladaptive behaviors, such as tactile defensiveness. Such altered sensory perception in autism spectrum disorders could arise from disruptions in experience-dependent maturation of circuits during early brain development. Here, we tested the hypothesis that synaptic structures of primary somatosensory cortex (S1) neurons in Fragile X syndrome (FXS), which is a common inherited cause of autism, are not modulated by novel sensory information during development. We used chronicin vivotwo-photon microscopy to image dendritic spines and axon “en passant” boutons of layer 2/3 pyramidal neurons in S1 of male and female WT andFmr1KO mice, a model of FXS. We found that a brief (overnight) exposure to dramatically enhance sensory inputs in the second postnatal week led to a significant increase in spine density in WT mice, but not inFmr1KO mice. In contrast, axon “en passant” boutons dynamics were impervious to this novel sensory experience in mice of both genotypes. We surmise that the inability ofFmr1KO mice to modulate postsynaptic dynamics in response to increased sensory input, at a time when sensory information processing first comes online in S1 cortex, could play a role in altered sensory processing in FXS.SIGNIFICANCE STATEMENTVery few longitudinalin vivoimaging studies have investigated synaptic structure and dynamics in early postnatal mice. Moreover, those studies tend to focus on the effects of sensory input deprivation, a process that rarely occurs during normal brain development. Early postnatal imaging experiments are critical because a variety of neurodevelopmental disorders, including those characterized by autism, could result from alterations in how circuits are shaped by incoming sensory inputs during critical periods of development. In this study, we focused on a mouse model of Fragile X syndrome and demonstrate how dendritic spines are insensitive to a brief period of novel sensory experience.
Alzheimer's Disease Risk Factor Pyk2 Mediates Amyloid-β-Induced Synaptic Dysfunction and Loss
Authors: Salazar Santiago V. , Cox Timothy O. , Lee Suho , Brody A. Harrison , Chyung Annabel S. , Haas Laura T. , Strittmatter Stephen M. 
Published: December 2018

Dozens of genes have been implicated in late onset Alzheimer's disease (AD) risk, but none has a defined mechanism of action in neurons. Here, we show that the risk factor Pyk2 (PTK2B) localizes specifically to neurons in adult brain. Absence of Pyk2 has no major effect on synapse formation or the basal parameters of synaptic transmission in the hippocampal Schaffer collateral pathway. However, the induction of synaptic LTD is suppressed in Pyk2-null slices. In contrast, deletion of Pyk2 expression does not alter LTP under control conditions. Of relevance for AD pathophysiology, Pyk2−/−slices are protected from amyloid-β-oligomer (Aβo)-induced suppression of LTP in hippocampal slices. Acutely, a Pyk2 kinase inhibitor also prevents Aβo-induced suppression of LTP in WT slices. Female and male transgenic AD model mice expressing APPswe/PSEN1ΔE9 require Pyk2 for age-dependent loss of synaptic markers and for impairment of learning and memory. However, absence of Pyk2 does not alter Aβ accumulation or gliosis. Therefore, the Pyk2 risk gene is directly implicated in a neuronal Aβo signaling pathway impairing synaptic anatomy and function.SIGNIFICANCE STATEMENTGenetic variation at the Pyk2 (PTK2B) locus is a risk for late onset Alzheimer's disease (AD), but the pathophysiological role of Pyk2 is not clear. Here, we studied Pyk2 neuronal function in mice lacking expression with and without transgenes generating amyloid-β (Aβ) plaque pathology. Pyk2 is not required for basal synaptic transmission or LTP, but participates in LTD. Hippocampal slices lacking Pyk2 are protected from AD-related Aβ oligomer suppression of synaptic plasticity. In transgenic AD model mice, deletion of Pyk2 rescues synaptic loss and learning/memory deficits. Therefore, Pyk2 plays a central role in AD-related synaptic dysfunction mediating Aβ-triggered dysfunction.
Mogens Westergaard’s Contributions to Understanding Sex Chromosomes
Authors: Charlesworth Deborah 
Published: December 2018

Abstract
Sixty years ago, Mogens Westergaard published a review analyzing genetic studies from a range of flowering plants. Westergaard provided strong genetic evidence that two separate factors are involved in sex...
A long-standing question in biology concerns the genetic mechanisms by which two sexes can evolve (botanists call this the dioecious condition and zoologists call it gonochory) from a functionally ancestral hermaphroditic state (without separate sexes). In 1932, H. J. Muller, one of the great 20th century geneticists but also a fine evolutionary biologist, pointed out that two mutations were necessary. It was therefore puzzling that sex determination often involves a single genetic locus. Muller believed that the evolution of a single-gene system was possible, because maize geneticists had synthesized a single-gene system with separate sexes. However, this system is highly artificial, requiring geneticists to actively eliminate the wild-type allele at one of the two genes involved. This genetic system cannot therefore explain the natural evolution of dioecy. In 1958, Westergaard reviewed studies from a diversity of flowering plants, and showed that the genetics of natural sex determination in plants does not support the maize system. Instead, the genetic results pointed to a model involving two separate factors, with close linkage creating a single genetic locus. Moreover, Westergaard also pointed out that a two-gene model offers a natural explanation for the evolution of suppressed recombination between sex chromosome pairs. Studying plants allowed genetic analyses of the early steps in the evolution of dioecy, using dioecious species that evolved recently from species without separate sexes, whereas Muller failed to fully understand such evolutionary changes because he focused on animals, where later changes have often happened and obscured the early stages.
Evolutionary Virology at 40
Authors: Geoghegan Jemma L , Holmes Edward C 
Published: December 2018

AbstractGeoghegan and Holmes describe the history of evolutionary ideas in the study of viruses, showing that two different approaches to studying virus evolution—the comparative and the experimental—were both established in seminal papers published in the late...RNA viruses are diverse, abundant, and rapidly evolving. Genetic data have been generated from virus populations since the late 1970s and used to understand their evolution, emergence, and spread, culminating in the generation and analysis of many thousands of viral genome sequences. Despite this wealth of data, evolutionary genetics has played a surprisingly small role in our understanding of virus evolution. Instead, studies of RNA virus evolution have been dominated by two very different perspectives, the experimental and the comparative, that have largely been conducted independently and sometimes antagonistically. Here, we review the insights that these two approaches have provided over the last 40 years. We show that experimental approaches using in vitro and in vivo laboratory models are largely focused on short-term intrahost evolutionary mechanisms, and may not always be relevant to natural systems. In contrast, the comparative approach relies on the phylogenetic analysis of natural virus populations, usually considering data collected over multiple cycles of virus–host transmission, but is divorced from the causative evolutionary processes. To truly understand RNA virus evolution it is necessary to meld experimental and comparative approaches within a single evolutionary genetic framework, and to link viral evolution at the intrahost scale with that which occurs over both epidemiological and geological timescales. We suggest that the impetus for this new synthesis may come from methodological advances in next-generation sequencing and metagenomics.
One of the main functions of an information security system is the identification of any access subject to be able to investigate information security incidents. During executing procedures of scanning and vulnerability exploitation, qualified adversaries
Authors: Iskhakov Andrey , Iskhakova Anastasia , Meshcheryakov Roman , Bendraou Reda , Melekhova Olga 
Published: December 2018

One of the main functions of an information security system is the identification of any access subject to be able to investigate information security incidents. During executing procedures of scanning and vulnerability exploitation, qualified adversaries regularly change identifying features. Such operations can not only obfuscate logging the data in subsystems, thus, complicating the restoring of events chronology for an information security expert but also call into question the irrefutability of the evidence of participation of particular adversary to particular illegal operations.
In the paper analyses of application of modern approaches of adversary identification in web resources, which does not require authentification of main part of users, is given (fingerprinting, analysis of behavioral features).
Along with widely used in web analytics “thermal maps”, user adapted profile and computer model of dynamics of “user-mouse” system, authors offer to identify the subjects of information security incident in readily available informational resources of the Internet. The main idea of the prospective approach consists of the following: when a thermal map is built, not only the density of data layout should be considered but also statistical parameters should be defined by an expert (the distance of intensity gradient, distance overlap, etc.). The authors also offer to consider the dynamics of user operations (e.g. calculation of the average duration of data entry into interactive elements). A description of each step of an appropriate technique and also information on its practical implementation are given. Robustness of the given approach is confirmed by a practical experiment. The offered technique is not a universal instrument of adversary identification . Only manual targeted attacks are considered, the cURL tools etc. used by adversaries are not taken into account. Therefore, it is recommended to use this technique exclusively in addition to working protective systems (WAF, IPS, IDS).
predictors of long-term fatal cardiovascular events after planned percutaneous coronary interventions
Authors: Vershinina E. O. , Repin A. N. 
Published: December 2018

Aim.To evaluate the frequency and identify predictors of long­term fatal cardiovascular events (CVE) after planned percutaneous coronary interventions (PCI).Material and methods. We conducted a retrospective study that included 150 patients who underwent planned endovascular intervention on the coronary arteries. Outcomes of interventions were assessed 6 years after the PCI, by analyzing medical records and telephone interviews. The primary endpoint of the study was cardiovascular­related death.Results.Fatal CVE were recorded in 10,6% of patients. A statistically significant relationship was found between the development of fatal CVE in the long­term period after planned PCI and the presence of initial chronic obstructive pulmonary disease in patients (OR=12,3; CI (3,6­41,5); р<0,001), atrial fibrillation (OR=5,1; CI (1,6­16,3); p=0,003), diabetes mellitus (OR=3,2; CI (1,1­9,8); p=0,032), acute cerebrovascular accident (OR=8,6; CI (2,0­36,4); p=0,001); any clinical complications of interventions (OR=3,1; CI (1,1­9,0); p=0,028), taking of antiarrhythmic drugs (OR=5,9; CI (1,3­27,4); p=0,012), statins taking at the time of PCI (OR=0,3; CI (0,1­0,8); p=0,013). According to the results of the ROC­analysis, the most significant predictor of fatal CVE in the long­term period was erythrocyte sedimentation rate more than 14,5 mm/h (AUC=0,677; CI (0,507­0,835); p=0,027). According to 6­year observation, Kaplan­Meier curves showed a significant effect of multifocal atherosclerosis, acute periprocedural kidney injury and heart rhythm disorders recorded during PCI, on the incidence of long­term fatal CVE.Conclusion.A statistically significant relationship between the development of fatal CVE in the long­term period after planned PCI and the presence of initial comorbid pathology in patients (chronic obstructive pulmonary disease, atrial fibrillation, diabetes mellitus, multifocal atherosclerosis, acute cerebrovascular accident), erythrocyte sedimentation rate more than 14,5 mm/h, concomitant drug therapy at the time of the intervention (taking of antiarrhythmic drugs, statins). Significant predictors of adverse long­term outcome after planned endovascular myocardial revascularization were clinical complications of PCI, recorded during the hospital period, especially acute periprocedural kidney injury and heart rhythm disorders.