bluuebunny/crossref_metadata_2025_split huggingface dataset:
Use of Direct Oral Anticoagulants in Patients with Cancer: Practical Considerations for the Management of Patients with Nausea or Vomiting
Authors: Riess Hanno , Ay Cihan , Bauersachs Rupert , Becattini Cecilia , Beyer-Westendorf Jan , Cajfinger Francis , Chau Ian , Cohen Alexander T. , Khorana Alok A. , Maraveyas Anthony , Renni Marcos , Young Annie M. 
Published: April 2018

Abstract

Direct oral anticoagulants (DOACs) have proven efficacy and safety and are approved for use in the prevention and treatment of thromboembolic events in patients with venous thromboembolism (VTE) and those with atrial fibrillation (AF). There is no clear guidance on the use of DOACs in the significant proportion of these patients who have or will develop concomitant cancer. The occurrence of nausea and vomiting in these patients, despite implementation of guideline-recommended antiemetic strategies, is a particular concern because it may affect oral drug intake and consequently outcomes with anticoagulation therapy.
Here, we review recent data on the incidence and management of cancer-associated nausea and vomiting and the current evidence and guidance relating to the use of DOACs in patients with cancer. On the basis of this evidence, an international working group of experts in the fields of cancer-associated thrombosis/hemostasis, hematology, and oncology discussed key issues related to the use of DOACs in patients with VTE or AF and cancer who are at risk of nausea and vomiting and developed some consensus recommendations. We present these consensus recommendations, which outline strategies for the use and management of anticoagulants, including DOACs, in patients with VTE or AF and cancer for whom oral drug intake may pose challenges. Guidance is provided on managing patients with gastrointestinal obstruction or nausea and vomiting that is caused by cancer treatments or other cancer-related factors.
The recommendations outlined in this review provide a useful reference for health care professionals and will help to improve the management of anticoagulation in patients with VTE or AF and cancer.

Implications for Practice
Direct oral anticoagulants (DOACs) offer several advantages over traditional anticoagulants, including ease of administration and the lack of need for routine monitoring. However, the management of patients with an indication for anticoagulation and concomitant cancer, who are at high risk of thromboembolic events, presents several challenges for administering oral therapies, particularly with regard to the risk of nausea and vomiting. In the absence of robust data from randomized trials and specific guidelines, consensus recommendations were developed for healthcare professionals regarding the use of DOACs in patients with cancer, with a focus on the management of patients who are at risk of nausea and vomiting.
Safen ven yetmezliklerinin n-butil siyanoakrilat embolizasyonu ile tedavisi: tek merkez bulguları
Authors: Ovalı Cengiz 
Published: April 2018

Amaç: Bu çalışmanın amacı N- butil siyanoakrilat embolizasyon (CAE) ile tedavi ettiğimiz ileri dereceli safen ven yetmezliklerindeki sonuçlarımızı sunmaktır. Gereç ve Yöntem: Kliniğimizde ileri dereceli safen ven yetmezliği nedeniyle CAE ile tedavi ettiğimiz 205 hasta çalışmaya dâhil edildi. Tüm hastalar CEAP (Clinical severity, Etiology, Anatomy, Pathophysiology) sınıflandırmasına göre ameliyat öncesi değerlendirildi. Postoperatif dönemde hastaların 1, 3 ve 6. aylarda kontrolleri yapılarak, klinik ve yaşam kalitesi değerlendirildi. Operasyon sonrası ve 6. aydaki yapılan Renkli Doppler Ultrasonografi (RDUS) sonuçları karşılaştırıldı. İşlemin uygulandığı damarın total oklüzyonu operasyonun başarısı olarak tanımlandı.Bulgular: Operasyon sonrası yapılan Doppler Ultrasonografi incelemelerinde hastaların tamamında safen vende total oklüzyon saptanırken (%100) 6. ayda yapılan Doppler Ultrasonografi incelemelerinde ise 1 hastada kısmı rekanalizasyon ve minimal reflü (%0,5) tespit edildi. 28 hastada (%13) istenmeyen olay – komplikasyon gelişti. Hastalar; ağrı, yanma, yorgunluk hissi, kaşıntı gibi semptomlarda 6. ayda % 90 – 96 iyileşme olduğunu ifade ederken sadece 2 hasta (%1) kötüleşme olduğunu belirtti. Sonuç: Siyanoakrilat Embolizasyon; yüksek oklüzyon ve başarı oranları, oldukça az komplikasyon ve yüksek hasta konforu sağlaması nedeniyle safen ven yetmezliklerinin tedavisinde güvenle kullanılabileceği kanaatindeyiz.
Gözetim Toplumu Yönetimi ve Turizm Endüstrisi Açısından Değerlendirilmesi
Authors: ÇAKMAK Tolga Fahri , İSTANBULLU DİNÇER Füsun 
Published: April 2018

Turizm
endüstrisi her geçen gün yenilik anlayışı doğrultusunda teknolojiye daha da
entegre olarak, küresel otomasyon sistemleri aracılığı ile turist
hareketliliklerini bireysel boyuttan toplumsal boyuta farklı katmanlar halinde
kayıt altına alarak turizm olayına katılanların izlenmesine daha şeffaf bir
biçimde olanak sağlamaktadır. Bu durum gözetim toplumu olarak adlandırılan ve
insanların izlenerek toplumsal güvenliğin sağlanması adı altında kısmen
yönlendirilmesine de sebebiyet vermektedir. Öte yandan gözetim, turizm
endüstrisi için bir sorun niteliği taşıyan müşterinin sadakatini sağlama
hususunda önemli bir strateji unsuru olmaya da başlamıştır. Bu çalışmanın amacı gözetim toplumu
kavramının turizm endüstrisinin geleceğinde nasıl bir role sahip olacağının,
işletmelerin yönetimsel ilkeleri içerisinde nasıl yer edineceğinin analizini
yapmaktır. Bu bağlamda ilgili alan literatürü taranmış ve kavramsal bir
çerçevede konu ele alınmıştır.
M1 M2 macrophage expression in menstrual blood flakes of women with endometriosis
Authors: Haslinda Yulisa , Sa’adi Ashon , Hendarto Hendy , Hoesin Faroek 
Published: April 2018

Objectives: to measure and prove the increase of panmacrophage, macrophages M1 and M2 expression and decrease of ratio of M1/M2 in menstrual blood flakes of women with endometriosis. Materials and Methods: This study was a cross sectional observational analytic study conducted on 30 subjects with endometriosis and non-endometriosis. Immunohistochemical staining was done on a sample of menstrual blood flakes of subjects study who were taken at the second or third day of menstrual cycles with CD68 and CD163 antibody to measure the expression of panmacrophage and M2 macrophages. Expression of M1 macrophages is the approach of a reduction expression of panmacrophage with M2 macrophages.Results: Expression of M1, M2 and the ratio M1/M2 in the both of groups had a normal distribution then continued by independent t-test with one-tailed α (0.05). Probability was considered statistically significant at p <0.05 with a confidence interval of 95%. Based on the statistical result, Mφ macrophage expression in endometriosis and control group amounted to 3.62 ± 0.50 and 2.80 ± 0.64 (p =0.0005) with non parametric test. The expression of M1 macrophages in endometriosis group and non endometriosis were respectively 1.40 ± 0.35 and 1.33 ± 0.40 (p =0.3005) and the expression of M2 in both of group, respectively of 2.23 ± 0.41 and 1.47 ± 0.36 (p =0.0005). The ratio of M1/M2, the endometriosis group and non endometriosis, respectively of 0.65 ± 0.20 and 0.92 ± 0.24 (p =0.0015).Conclusion: this study were significant increased in the panmacrophage Mφ, M2 macrophages expression on a woman's menstrual blood flakes endometriosis and significant decreased in ratio M1/M2 in the woman's menstrual blood flakes endometriosis.
Genotype of human papilloma virus in invasive cervical carcinoma at Dr. Soetomo Hospital Surabaya
Authors: Kore Markus , Mastutik Gondo , Mustokoweni Sjahjenny 
Published: April 2018

Objectives: To identify the variants of genotype HPV that most often found in ICC at Dr Soetomo Hospital Surabaya.Materials and Methods: This was an explorative study with cross sectional approach. Specimens used were 30 formalin fix parrafin embedded from squamous cell carcinoma (SCC), adenocarcinoma (AD) dan adenosquamous carcinoma (AS) cervival cancer parients at Dr Soetomo Hospital Surabaya around Januari-Desember 2013, then used for DNA virus extraction and continued for PCR and HPV genotyping.Result : The result of HPV genotyping showed 10 positives from SCC, 6 positives and 4 negatives from AD, and 9 positives and 1 negative from AS. HPV infections in SCC were single infection by HPV 16, 18, 45, 56, and multiple infection by HPV 16+45, in AD were single infection by HPV 16,18, anad multiple infection by HPVhr+hr 68b+72 and HPVlr+hr 6+18+45, and in AS were single infection by HPVhr 16, 18, 45 and mutiple infection by HPV lr+hr 6+59.Conclusion : Infections HPV in ICC were single infection by HPV16, 18, 45, 56 and mutiple infection by HPV16+45, 68b+72, 6+18+45, 6+59. HPV 18 has highest prevalence in ICC patient from Dr Soetomo Hospital, followed by HPV16, 6, 45, 56, 59.
KOMPETENSI GURU PENDIDIKAN JASMANI SEKOLAH DASAR
Authors: Mulyana Mulyana 
Published: April 2018

This study aims to determine the competency of Physical Education Teacher in Elementary Schools (SD). The study population are all Physical Education Teachers. Samples taken from 30 teachers, while the technique is using simple random sampling. The method used is descriptive survey. Data obtained using a likert scale instrument to capture data; pedagogic competence, personal competence, sosial competence, and professional competence. The results of this study concluded that teachers of Physical Education in Primary Schools have the ability to teach well the field of Physical Education, in charge of teaching materials. But teachers are still weak in the mastery of the concept of sports science. Not all teachers can use information and communication technology in teaching Physical Education. The ability of teachers to develop themselves in a professional activity that is also not adequate.

Abstrak

Penelitian ini bertujuan untuk mengetahui kompetensi guru Pendidikan Jasmani Sekolah Dasar (SD). Metode penelitian yang digunakan adalah survey deskriptif. Data diperoleh dengan menggunakan instrumen skala likert untuk menjaring data; kompetensi pedagogik, kompetensi kepribadian, kompetensi sosial, dan kompetensi professional. Hasil penelitian ini menyimpulkan bahwa guru Pendidikan Jasmani di SD mampu mengajar Pendidikan Jasmani yang baik dan menguasi materi ajar. Namun disisi lain, masih terdapat kelemahan dalam penguasaan konsep keilmuan olah raga, selain itu tidak semua guru dapat memanfaatkan teknologi informasi dan komunikasi dalam pembelajaran Pendidikan Jasmani. Kemampuan guru dalam mengembangkan diri pada kegiatan profesional juga belum memadai.
A REPARTIÇÃO TRIBUTÁRIA DOS RECURSOS DO ICMS NOS MUNICÍPIOS DO EXTREMO OESTE DE SANTA CATARINA
Authors: Griebler Keli Fátima , Scheren Gilvane , Oro Ieda Margarete 
Published: April 2018

O objetivo deste artigo é investigar a relação entre o valor proveniente da arrecadação de ICMS, oriundo do movimento econômico municipal, e as transferências governamentais da cota-parte do ICMS, repassada pelo governo estadual, nos municípios integrantes da Associação dos Municípios do Extremo Oeste de Santa Catarina (AMEOSC). O estudo caracteriza-se como descritivo e documental, com abordagem quantitativa. A população compreendeu os 295 municípios do Estado de Santa Catarina, e a amostra constituiu-se dos 19 municípios pertencentes a AMEOSC. As informações da pesquisa foram coletadas nos sites do Tribunal de Contas do Estado, Secretaria de Estado da Fazenda de Santa Catarina e IBGE. Os resultados demonstram que a cota-parte do ICMS possui peso significativo na receita dos municípios, para que estes possam prestar serviços básicos a sua população e que munícipios de menor porte e moderado movimento econômico tendem a apresentar maior grau de dependência da transferência da cota-parte do ICMS.
An Automated Laboratory Method for Measuring CO2 Emissions from Soils
Authors: McGowen Eric B. , Sharma Sumit , Deng Shiping , Zhang Hailin , Warren Jason G. 
Published: April 2018

Core Ideas
A GC method to measure soil CO2 emission was developed and compared with Solvita CO2 burst method.
A strong exponential relationship between Solvita and GC method was observed.
CO2 emissions from soils increased with drying temperature to a maximum at 65°C.
The data presented highlight the narrow linear range of the Solvita method.
The standardized procedure increased rate of analysis and reduced costs.
A gas chromatography (GC) headspace method was developed for soil microbial respiration (CO2 emission) analysis after a 24‐h incubation of a rewetted soil. The GC method was compared with the Solvita CO2 burst method by analyzing 18 different soils that were air‐dried (22°C) or dried at 45, 65, and 105°C for 24 h before rewetting. A strong exponential relationship between the Solvita color number and GC headspace CO2–C emission was observed. Compared with air‐dried soils, drying at 65°C led to increased CO2 emission and reduced variation among sample replicates, while drying at 105°C led to a reduction in CO2 emission and an increase in variability. The GC method does not require sample dilution, provides data that is highly correlated to the Solvita method, and has a wider dynamic test range than the Solvita method. The developed GC method could be adapted to automation for commercial laboratory use.
Mulch Based No‐Tillage and Compost Effects on Nitrogen Fertility in Organic Melon
Authors: Tittarelli Fabio , Campanelli Gabriele , Leteo Fabrizio , Farina Roberta , Napoli Rosario , Ciaccia Corrado , Canali Stefano , Testani Elena 
Published: April 2018

Core Ideas
No‐till roller crimper was confirmed to be a suitable technology for weed management.
Melon yield and quality declined under no‐till roller crimped barley.
Compost application and agro‐ecological service crop cultivation showed high potential carbon sink effect.
Cropping systems and varieties should be adapted to no‐till roller crimper.
Agro‐ecological service crop management and compost should be combined to fit the specific local conditions.
Soil fertility management in organic farming systems relies on agro‐ecological service crops (ASCs, i.e break crops, living mulch) and organic compost application. This study was conducted to determine the effect of tillage, ASC termination, and compost rates on yield and soil N fertility in organic vegetable production in Central Italy. In a long‐term organic field, in a strip plot design, barley was cultivated before melon. Two termination strategies of barley (green manure–GM, flattening by the use of a roller crimper–RC) were compared with a control without barley (FA). Three compost application rates (0, 15, and 30 Mg ha−1) were studied. While the compost rates did not show any difference among compared production parameters, the combined tillage–ASC termination strategy significantly increased melon yield in the GM compared with RC treatments, probably due to the lower soil temperature under the thick barley mulch. Soil mineral N (SMN) during the melon cycle was not a limiting factor for plant growth. Mean SMN values ranged from 22 for the 2012 RC and 36 mg kg−1 for the 2012 FA. High C and N inputs in barley treatments and high compost rates indicated an N surplus, which, in the medium–long term, could represent an N storage for subsequent crops in the rotation and potentially determine C sequestration. The results demonstrated that, to assure adequate yield, the ASC mulch based no‐tillage approach should follow the redesign of the whole cropping system, taking into account the entire suite of techniques of crop management.
Hydrophysical Database for Brazilian Soils (HYBRAS) and Pedotransfer Functions for Water Retention
Authors: Ottoni Marta Vasconcelos , Ottoni Filho Theophilo Benedicto , Schaap Marcel G. , Lopes-Assad Maria Leonor R.C. , Rotunno Filho Otto Corrêa 
Published: April 2018

Core Ideas
We propose a Hydrophysical Database for Brazilian Soils (HYBRAS).
Data in HYBRAS comprise 445 soil profiles, with 1075 samples of Brazilian soils.
We compared the accuracy of water retention estimates based on climate‐based PTFs.
In general, the Brazilian PTFs performed better than the temperate models for HYBRAS.
Model performance differed due to clay content and mineralogical properties.
Soil water retention data are fundamental in soil modeling studies. Temperate pedotransfer functions (PTFs) have been commonly used to estimate water retention of Brazilian soils, mainly because of the lack of soil data for Brazil. However, these PTFs may not be suitable for tropical or subtropical conditions such as those found in Brazil. The objective of this study was to establish a dedicated Hydrophysical Database for Brazilian Soils (HYBRAS) suitable for PTF development. Data present in HYBRAS comprise 445 soil profiles with 1075 samples and are representative of a wide range of Brazilian soils. The data are organized in a relational structure of tables that cover general site descriptions, land cover, and hydrophysical and chemical measurement methods. Raw data (e.g., water retention points covering the 0–15,000‐cm suction range) and derived data are included in the tables. Another objective of this study was to use the database to compare the accuracy of water retention estimates based on PTFs developed for Brazilian and temperate regions. In general, the Brazilian PTFs performed better than the temperate models, especially for weathered (Ferralsols, Acrisols, and Nitisols) fine‐textured (clay, sandy clay, clay loam, silty clay loam, and silty clay) soils. Silt content was not a successful criterion for distinguishing performance of Brazilian and temperate PTFs for Brazilian weathered soils. The water retention of weathered soils was shown to differ from that of temperate soils due to differences in pore structure resulting from their clay content and mineralogical nature, thus confirming results reported in the literature.
Impact of Temporal Macropore Dynamics on Infiltration: Field Experiments and Model Simulations
Authors: Reck Arne , Jackisch Conrad , Hohenbrink Tobias L. , Schröder Boris , Zangerlé Anne , van Schaik Loes 
Published: April 2018

Core Ideas
Dynamics of earthworm activity change macropore networks temporally.
In the topsoil, macropore numbers were largest in autumn and smallest in summer.
Temporal dynamics in macropore networks affected their hydrological impact.
Modeling confirmed that temporal macropore dynamics affect infiltration patterns.
Macropores greatly affect water and solute transport in soils. Most macropores are of biogenic origin; however, the resulting seasonal dynamics are often neglected. Our study aimed to examine temporal changes in biopore networks and the resulting infiltration patterns. We performed infiltration experiments with Brilliant Blue on pastureland in the Luxembourgian Attert catchment (spring, summer, and autumn 2015). We developed an image‐processing scheme to identify and quantify changes in biopores and infiltration patterns. Subsequently, we used image‐derived biopore metrics to parameterize the ecohydrological model echoRD (ecohydrological particle model based on representative domains), which includes explicit macropore flow and interaction with the soil matrix. We used the model simulations to check whether biopore dynamics affect infiltration. The observed infiltration patterns revealed variations in both biopore numbers and biopore–matrix interaction. The field‐observed biopore numbers varied over time, mainly in the topsoil, with the largest biopore numbers in spring and the smallest in summer. The number of hydrologically effective biopores in the topsoil seems to determine the number and thereby the fraction of effective biopores in the subsoil. In summer, a strong biopore–matrix interaction was observed. In spring, the dominant process was rapid drainage, whereas in summer and autumn, most of the irrigated water was stored in the examined profiles. The model successfully simulated infiltration patterns for spring, summer, and autumn using temporally different macropore setups. Using a static macropore parameterization the model output deviated from the observed infiltration patterns, which emphasizes the need to consider macropores and their temporal dynamics in soil hydrological modeling.
Measuring and Modeling Stable Isotopes of Mobile and Bulk Soil Water
Authors: Sprenger Matthias , Tetzlaff Doerthe , Buttle Jim , Laudon Hjalmar , Leistert Hannes , Mitchell Carl P.J. , Snelgrove Jenna , Weiler Markus , Soulsby Chris 
Published: April 2018

Core Ideas
Bulk soil water isotopes have an evaporation signal, but mobile water isotopes do not.
These differences are time variant and linked to the volume and age of the mobile water.
Two pore domains (fast and slow) improve simulations of soil water isotope dynamics.
A new model accounts for isotopic exchange via water vapor between two pore domains.
This exchange is relevant for proper simulation of the evaporation signal in bulk soil water.
Recent findings from stable isotope studies have opened up new questions about differences in the isotopic composition (δ2H and δ18O) of mobile (MW) and bulk water (BW) in soils. We sampled the isotopic compositions of MW using suction lysimeters and BW with the direct‐equilibration method. The study was conducted at two landscape units in each of three catchments: the Bruntland Burn (Scotland), Dorset (Canada), and Krycklan (Sweden). We further used the numerical one‐dimensional flow model SWIS (Soil Water Isotope Simulator) to simulate the hydrometric and isotopic dynamics. The model included evaporation fractionation, allowed differentiation between a fast and a slow flow domain, and included isotopic exchange via water vapor. Our measurements showed that MW plots along the local meteoric water lines, whereas BW plots below, which is indicative of evaporation fractionation. We suggest that the relative volume of MW to BW is relevant for explaining these isotopic differences because MW volumes are usually relatively low during periods of high evaporation. Under this condition, differences between MW and plant water isotopes are not paradoxical but rather related to the water that cannot be sampled with suction lysimeters but is still available for plant water uptake. The simulations accounting for fast and slow flow supported the conceptualization of the two soil pore domains with isotopic exchange via vapor exchange because this model setup resulted in the best model performance. Overall, these findings are of high relevance for current understanding related to the source and isotopic composition of water taken up by plants.