bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation des Gesundheitsverhaltens und der Lebensqualität dermatoonkologischer Patienten nach operativer Therapie eines Hauttumors
Authors: Hoernecke D. , Pföhler C. , Wagenpfeil S. , Vogt T. , Müller C. 
Published: September 2018

Zusammenfassung
Hintergrund In der Onkologie existieren unterschiedliche Erkenntnisse bzgl. einer Änderung im Gesundheitsverhalten der betroffenen Patienten nach Diagnosestellung eines malignen Tumors (z. B. beim kolorektalen Karzinom oder bei gynäkologischen Karzinomen). Derlei Daten existieren bislang nicht in größerem Umfang für dermatoonkologische Patienten.
Fragestellung Ziel dieser Querschnittstudie mittels Fragebogen und Korrelation mit retrospektiven Daten war es, herauszufinden, ob Hauttumorpatienten ihr Gesundheitsverhalten (Sonnenexposition, Freizeitverhalten, Raucherentwöhnung etc.) nach dermatochirurgischer Therapie/Behandlung ändern und damit den ärztlichen Empfehlungen folgen. Zudem wurde die Lebensqualität der Patienten nach operativer Therapie von Hauttumoren erfasst.
Material und Methoden In die Studie wurden 653 Patienten eingeschlossen, welche im Jahre 2013 unter stationären Bedingungen aufgrund eines oder mehrerer maligner Hauttumore operativ behandelt wurden. Mittels Fragebögen wurden die postoperative Lebensqualität sowie das Freizeit- und Gesundheitsverhalten erfasst und analysiert. Ergebnisse: 263/653 Patienten nahmen an der Befragung teil (Rücklaufquote 40,3 %). 62,0 % der Patienten waren männlich, 38,0 % weiblich. Der Altersdurchschnitt lag bei 69,8 Jahren. Überraschenderweise konnten wir eine Umstellung der Lebensweise hin zu gesünderen Eigenschaften (Reduktion des Alkoholkonsums, gesündere Ernährung) und Reduktion der Risikofaktoren (Reduktion der Sonnenexposition und Schutz vor UV-Strahlung) feststellen. Eine Abhängigkeit der Verhaltensänderungen vom Bildungsstand, Geschlecht oder dem Familienstand ergab sich hingegen nicht. Die Nutzung textilen Sonnenschutzes sowie der Umgang mit sportlicher Betätigung änderte sich nicht. Hinsichtlich der Lebensqualität zeigten sich unsere Patienten generell zufriedener als die deutsche Allgemeinbevölkerung. Weibliches Geschlecht, das Leben mit einem Partner, ein hohes Bildungsniveau sowie höheres Lebensalter wirkten sich bei unseren Patienten positiv auf die Lebensqualität aus.
Diskussion Vor dem Hintergrund einer weiter notwendigen Verbesserung der primären und auch sekundären Präventionsmaßnahmen erscheint auch eine Optimierung spezifischer Aufklärungsinhalte in der Dermatoonkologie notwendig. Insbesondere der Einfluss einer gesunden Lebensweise spielt hier eine Rolle. Die Auswirkungen der Hautkrebserkrankung auf die Lebensqualität waren geringer als von uns erwartet. Dies kann als Ursprung für den verminderten Antrieb zur Lebensstilveränderung gesehen werden.
Limitationen Der Homburger Gesundheitsbogen wurde eigens entwickelt und nicht in Testverfahren validiert. Die Patienten wurden nur einmalig angeschrieben. Erinnerungsmaßnahmen oder Incentives wurden nicht genutzt.
Endoscopic Assisted Retrosigmoid Approach for Cerebellopontine Angle Epidermoid Tumor
Authors: Kunigelis Katherine , Yang Alexander , Youssef A. 
Published: September 2018

This case is a 20-year-old male, who presented with 1 month of right facial weakness (HB4) and complaints of ipsilateral eye dryness. He was initially treated for Bell's palsy with steroids and antiviral agents, but subsequently developed diplopia with right lateral gaze and underwent an MRI (magnetic resonance imaging). MRI demonstrated a 4.5 cm irregular lesion in the right cerebellopontine angle consistent with an epidermoid cyst. Because the tumor had grown with the development of the central nervous system, it has extended into different compartments, including the tentorial incisura and pineal region. A predefined surgical corridor created by the tumor facilitated access to the majority of the tumor through a retrosigmoid approach. Angled endoscopes (30-degree up and down) provided further visualization of tumor away from the line of sight of the microscope, thus allowing for gross total resection of the lesion. This video also demonstrates a sharp dissection technique necessary for safe removal of adherent tumor from critical neurovascular structures, including the basilar artery and several cranial nerves. The ipsilateral auditory evoked responses (ABRs) showed slight improvement from baseline toward the end of the case. A gross total resection was achieved, as shown by the MRI. The patient remained at his baseline cranial nerve (CN) V, VII, and VIII deficits during the immediate postoperative period.The link to the video can be found at: https://youtu.be/vCq5juJh8hk.
Retrosigmoid Craniotomy for Resection of an Epidermoid Cyst of the Posterior Fossa
Authors: Kalani M. , Couldwell William 
Published: September 2018

This video illustrates the case of a 51-year-old woman who presented with sudden-onset headache, vertigo, and nausea. Imaging revealed an epidermoid cyst of the posterior fossa with mass effect upon the brainstem and displacement of the basilar artery. This lesion was approached using a left-sided keyhole retrosigmoid craniotomy with monitoring of the cranial nerves. This video illustrates the technique of internal debulking of the cyst contents with minimal manipulation of the cyst capsule, which is often densely adherent to the brainstem, cranial nerves, and vessels in the posterior fossa. Resection of the capsule is often associated with a higher rate of cranial nerve deficits. The tumor was removed completely, but the cyst capsule was left in place. The patient had House–Brackmann grade II facial paralysis postoperatively and complained of some diminished hearing in the left ear. Epidermoid cysts are benign tumors, but the patient may experience much morbidity from their overly aggressive resection, especially when the capsule is densely adhering to critical structures. An alternate strategy is to decompress the contents of the epidermoid cyst, thereby decompressing the brainstem and converting this disease process into a chronic disease that may require reoperation in the long term. Given the tight confines of the posterior fossa, aggressive internal decompression of tumors and mobilization from the brainstem and adjacent nerves are key to avoiding injury to the brainstem and cranial neuropathies. In patients with benign tumors, the goal of the operation should be decompression of the brainstem and preservation of cranial nerve function.The link to the video can be found at: https://youtu.be/nk8-VztB0OI.
The Use of Fetal Bronchoscopy in the Diagnosis and Management of a Suspected Obstructive Lung Mass
Authors: Chon Andrew , Stein James , Gerstenfeld Tammy , Wang Larry , Vazquez Walter , Chmait Ramen 
Published: September 2018

AbstractEtiologies of fetal lung anomalies include congenital pulmonary airway malformation (CPAM), intra- or extralobar pulmonary sequestration, congenital high airway obstruction syndrome (CHAOS), bronchogenic cyst, and bronchial atresia. Fetal tracheobronchoscopy has been reported both as a diagnostic and therapeutic procedure in the setting of severe congenital lung lesions. In this case report, prenatal imaging of a fetus with a large chest mass was suspicious for an obstructive bronchial lesion. The absence of visible normal lung tissue on the right side and mass effect on the left side raised the concern for pulmonary hypoplasia. After antenatal betamethasone and a period observation, hydropic changes developed. Fetal tracheobronchoscopy was then performed in an effort to identify and decompress the suspected obstructive bronchial lesion. Other than release of bronchial debris, no anatomical abnormalities were visualized. However, the right lung lesion and mediastinal shift both decreased after the fetal bronchoscopy. The newborn underwent postnatal resection of a CPAM Type II and is doing well. We hypothesize that fetal tracheobronchoscopy provided the following potential diagnostic and therapeutic benefits: (1) exclusion of an obstructive bronchial lesion; (2) disimpaction of bronchial debris from the saline lavage that we posit may have contributed to the rapid reduction in CPAM size.
Structural evidence for the roles of divalent cations in actin polymerization and activation of ATP hydrolysis
Authors: Scipion Clement P. M. , Ghoshdastider Umesh , Ferrer Fernando J. , Yuen Tsz-Ying , Wongsantichon Jantana , Robinson Robert C. 
Published: September 2018

Significance
Actin polymerization is a divalent cation-dependent process. Here we identify a cation binding site on the surface of actin in a 2.0-Å resolution X-ray structure of actin and find evidence of three additional sites in published high-resolution structures. These cations are stable in molecular dynamics (MD) simulations of the filament, suggesting a functional role in polymerization or filament rigidity. Polymerization activates the ATPase activity of the incorporating actin protomers. Careful analysis of water molecules that approach the ATP in the MD simulations revealed Gln137-activated water to be in a suitable position in F-actin, to initiate attack for ATP hydrolysis, and its occupancy was dependent on bound cations.
RMTL: an R library for multi-task learning
Authors: Cao Han , Zhou Jiayu , Schwarz Emanuel 
Published: September 2018

Abstract

Motivation
Multi-task learning (MTL) is a machine learning technique for simultaneous learning of multiple related classification or regression tasks. Despite its increasing popularity, MTL algorithms are currently not available in the widely used software environment R, creating a bottleneck for their application in biomedical research.

Results
We developed an efficient, easy-to-use R library for MTL (www.r-project.org) comprising 10 algorithms applicable for regression, classification, joint predictor selection, task clustering, low-rank learning and incorporation of biological networks. We demonstrate the utility of the algorithms using simulated data.

Availability and implementation
The RMTL package is an open source R package and is freely available at https://github.com/transbioZI/RMTL. RMTL will also be available on cran.r-project.org.

Supplementary information
Supplementary data are available at Bioinformatics online.
A systematic method for surveying data visualizations and a resulting genomic epidemiology visualization typology: GEViT
Authors: Crisan Anamaria , Gardy Jennifer L , Munzner Tamara 
Published: September 2018

Abstract

Motivation
Data visualization is an important tool for exploring and communicating findings from genomic and healthcare datasets. Yet, without a systematic way of organizing and describing the design space of data visualizations, researchers may not be aware of the breadth of possible visualization design choices or how to distinguish between good and bad options.

Results
We have developed a method that systematically surveys data visualizations using the analysis of both text and images. Our method supports the construction of a visualization design space that is explorable along two axes: why the visualization was created and how it was constructed. We applied our method to a corpus of scientific research articles from infectious disease genomic epidemiology and derived a Genomic Epidemiology Visualization Typology (GEViT) that describes how visualizations were created from a series of chart types, combinations and enhancements. We have also implemented an online gallery that allows others to explore our resulting design space of visualizations. Our results have important implications for visualization design and for researchers intending to develop or use data visualization tools. Finally, the method that we introduce is extensible to constructing visualizations design spaces across other research areas.

Availability and implementation
Our browsable gallery is available at http://gevit.net and all project code can be found at https://github.com/amcrisan/gevitAnalysisRelease.

Supplementary information
Supplementary data are available at Bioinformatics online.
Chromosomal-level assembly of yellow catfish genome using third-generation DNA sequencing and Hi-C analysis
Authors: Gong Gaorui , Dan Cheng , Xiao Shijun , Guo Wenjie , Huang Peipei , Xiong Yang , Wu Junjie , He Yan , Zhang Jicheng , Li Xiaohui , Chen Nansheng , Gui Jian-Fang , Mei Jie 
Published: September 2018

Abstract

Background
The yellow catfish, Pelteobagrus fulvidraco, belonging to the Siluriformes order, is an economically important freshwater aquaculture fish species in Asia, especially in Southern China. The aquaculture industry has recently been facing tremendous challenges in germplasm degeneration and poor disease resistance. As the yellow catfish exhibits notable sex dimorphism in growth, with adult males about two- to three-fold bigger than females, the way in which the aquaculture industry takes advantage of such sex dimorphism is another challenge. To address these issues, a high-quality reference genome of the yellow catfish would be a very useful resource.

Findings
To construct a high-quality reference genome for the yellow catfish, we generated 51.2 Gb short reads and 38.9 Gb long reads using Illumina and Pacific Biosciences (PacBio) sequencing platforms, respectively. The sequencing data were assembled into a 732.8 Mb genome assembly with a contig N50 length of 1.1 Mb. Additionally, we applied Hi-C technology to identify contacts among contigs, which were then used to assemble contigs into scaffolds, resulting in a genome assembly with 26 chromosomes and a scaffold N50 length of 25.8 Mb. Using 24,552 protein-coding genes annotated in the yellow catfish genome, the phylogenetic relationships of the yellow catfish with other teleosts showed that yellow catfish separated from the common ancestor of channel catfish ~81.9 million years ago. We identified 1,717 gene families to be expanded in the yellow catfish, and those gene families are mainly enriched in the immune system, signal transduction, glycosphingolipid biosynthesis, and fatty acid biosynthesis.

Conclusions
Taking advantage of Illumina, PacBio, and Hi-C technologies, we constructed the first high-quality chromosome-level genome assembly for the yellow catfish P. fulvidraco. The genomic resources generated in this work not only offer a valuable reference genome for functional genomics studies of yellow catfish to decipher the economic traits and sex determination but also provide important chromosome information for genome comparisons in the wider evolutionary research community.
Cardiomyopathy and altered integrin-actin signaling in Fhl1 mutant female mice
Authors: Kubota Akatsuki , Juanola-Falgarona Martí , Emmanuele Valentina , Sanchez-Quintero Maria Jose , Kariya Shingo , Sera Fusako , Homma Shunichi , Tanji Kurenai , Quinzii Catarina M , Hirano Michio 
Published: September 2018

Abstract
X-linked scapuloperoneal myopathy (X-SM), one of Four-and-a-half LIM 1 (FHL1) related diseases, is an adult-onset slowly progressive myopathy, often associated with cardiomyopathy. We previously generated a knock-in mouse model that has the same mutation (c.365 G &gt; C, p.W122S) as human X-SM patients. The mutant male mouse developed late-onset slowly progressive myopathy without cardiomyopathy. In this study, we observed that heterozygous (Het) and homozygous (Homo) female mice did not show alterations of skeletal muscle function or histology. In contrast, 20-month-old mutant female mice showed signs of cardiomyopathy on echocardiograms with increased systolic diameter [wild-type (WT): 2.74 ± 0.22 mm, mean ± standard deviation (SD); Het: 3.13 ± 0.11 mm, P &lt; 0.01; Homo: 3.08 ± 0.37 mm, P &lt; 0.05) and lower fractional shortening (WT: 31.1 ± 4.4%, mean ± SD; Het: 22.7 ± 2.5%, P &lt; 0.01; Homo: 22.4 ± 6.9%, P &lt; 0.01]. Histological analysis of cardiac muscle revealed frequent extraordinarily large rectangular nuclei in mutant female mice that were also observed in human cardiac muscle from X-SM patients. Western blot demonstrated decreased Fhl1 protein levels in cardiac muscle, but not in skeletal muscle, of Homo mutant female mice. Proteomic analysis of cardiac muscle from 20-month-old Homo mutant female mice indicated abnormalities of the integrin signaling pathway (ISP) in association with cardiac dysfunction. The ISP dysregulation was further supported by altered levels of a subunit of the ISP downstream effectors Arpc1a in Fhl1 mutant mice and ARPC1A in X-SM patient muscles. This study reveals the first mouse model of FHL1-related cardiomyopathy and implicates ISP dysregulation in the pathogenesis of FHL1 myopathy.
Extended experimental study on PSO with partial population restart based on complex network analysis
Authors: Pluhacek Michal , Viktorin Adam , Senkerik Roman , Kadavy Tomas , Zelinka Ivan 
Published: September 2018

Abstract
This extended study presents a hybridization of particle swarm optimization (PSO) with complex network construction and analysis. A partial population restart is performed in certain moments of the run of the algorithm based on the information obtained from a complex network analysis. The complex network structure represents the communication in the population. We present experimental results of the method alongside with statistical evaluation and discuss future possibilities of this approach. The main goal of the work is not to propose a new highly competitive PSO variant but to present the possibility of using the unconventional tool as an alternative to conventional diversity measures. The main benefit of the network analysis is that it has same-time requirements regardless of the dimension of the problem.
Margaret Cavendish
Authors: Boyle Deborah 
Published: September 2018

Margaret Cavendish, Duchess of Newcastle (b.1623–d. 1673), published at least six works of natural philosophy under her own name (the number depends on how one counts various second editions she published). Her prolific output also included poems, plays, essays, speeches, stories, science fiction, and letters to fictional correspondents. Despite Cavendish’s own desire for fame, her reputation suffered at the hands of readers and biographers who dismissed her philosophical writings without giving them any serious consideration. However, interest in Cavendish’s philosophical theories has increased exponentially since the 1980s. Much of the secondary literature published in the 1980s and 1990s aimed to dispel the idea that Cavendish is not worthy of study and to establish both that Cavendish’s writings were informed by her careful readings of the work of her contemporaries and that Cavendish’s own philosophical thinking consisted of a detailed, internally consistent alternative to the mechanistic natural philosophy embraced by many of those contemporaries. Now, fortunately, scholars do not feel the need to justify their study of Cavendish. Secondary literature published since the early 2000s on Cavendish’s philosophical work starts from the assumptions that studying Cavendish’s works enriches our understanding of the landscape of 17th-century philosophy and that the details of Cavendish’s views are inherently worth analyzing. The secondary literature on Cavendish is now extensive and comes from many disciplines—English literature, philosophy, history, history of science, political science, and cultural studies, among others—and, accordingly, draws on a variety of methodological approaches. This article focuses on Cavendish’s philosophical views and includes secondary literature that is based on close textual analysis and sensitivity to the historical and philosophical contexts in which Cavendish was writing. Works are divided into the following sections: Primary Sources, Modern Editions, Digital Scholarship, Biographies, Overviews, Anthologies, Epistemology, Mathematics, Medicine, Natural Philosophy, Political and Social Philosophy, Religion and Theology, and Rhetorical Style.
Rithy Panh
Authors: Polmuk Chairat 
Published: September 2018

Rithy Panh (b. 1964) is an internationally and critically acclaimed Cambodian filmmaker and screenwriter. A survivor of the genocidal Khmer Rouge regime (1975–1979), Panh spent a year at a refugee camp in Thailand and another ten years in France, where he attended the prestigious Institut des Hautes Études Cinématographiques (Institute for advanced cinematographic studies). Panh’s first documentary film Site 2 (1989) documents lives of his compatriots at the refugee camp at a Cambodian-Thai border area; it also marks the filmmaker’s return to Cambodia to confront the country’s past violence and its continuing impact on the present. The cinema of Rithy Panh is thus well known for its thematic emphasis on the traumatic experience of genocide, displacement, and exploitation. His fiction films such as Rice People (1994) and One Evening After the War (1998), as well as documentaries such as The Land of the Wandering Souls (2000) and People of Angkor (2003), showcase Pan’s sustained meditations on socioeconomic struggles in post-genocide Cambodia. During the past decades, Panh’s documentary practices and experimental aesthetics have rekindled critical attention to the complex relations between film and memory, visual representation and ethics, and media testimony and justice. His 2003 documentary film S–21: The Khmer Rouge Killing Machine, in which Khmer Rouge survivors reenact their memories at the notorious Tuol Sleng prison center (known by its code name S–21), has sparked scholarly debates regarding the method of reenactment in relation to trauma. The use of hand-carved clay figurines in his 2013 film The Missing Picture demonstrates another inventive feature of Panh’s documentary aesthetics. The film won Cannes’ Un Certain Regard award and was nominated for the Academy Award for Best Foreign Language Film. Panh’s transnational trajectory sheds light on the general context of postcolonial Southeast Asian cinema as well as the particular situation of the contemporary Cambodian film industry. In 2006, Panh co-founded the Bophana Audiovisual Resource Center in Phnom Penh, an archive of records from the Khmer Rouge period and beyond and a training center for a new generation of Cambodian filmmakers. The Bophana Center is named after Hout Bophana, a woman who was executed under the Pol Pot regime and who inspired Panh’s 1996 film Bophana: A Cambodian Tragedy. Panh has recently expanded his cinematic practices, serving as a co-producer of the Netflix adaptation of Loung Ung’s memoir about the Cambodian genocide, First They Killed My Father (dir. Angelina Jolie, 2017). Panh also curated the multimedia installation Exile, which accompanied his 2017 film by the same name, and directed a stage production, Bangsokol: A Requiem for Cambodia (2018).