bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dynamics of settling‐driven convection beneath a sediment‐laden buoyant overflow: Implications for the length‐scale of deposition in lakes and the coastal ocean
Authors: Davarpanah Jazi Shahrzad , Wells Mathew G. 
Published: August 2019

AbstractA series of laboratory experiments was conducted in order to determine how settling‐driven convection influences the length‐scale over which the majority of particles settle beneath a buoyant sediment‐laden plume spreading over a denser saline layer. This system is analogous to sediment‐laden river water spreading into a lake or the coastal ocean. The key dimensionless parameter that controls the settling dynamics of such flows is the density ratio, defined as the ratio of density differences due to the added salt and sediment. For a buoyant plume, this ratio has to be greater than unity, so that the experiments in the current study were performed for density ratios between one and five. When density ratio was close to one, settling‐driven convection was vigorous and the length‐scale over which sedimentation occurred was very small. A strong secondary turbidity current was generated in this case. On the other hand, for larger values of density ratio, the predicted length‐scale over which a secondary plume was generated increased in proportion to the density ratio. A complete mathematical expression for this length‐scale was developed using recent theory that described the timescale over which settling‐driven convection evolved. The theoretically predicted propagation length‐scale showed very good quantitative agreement with laboratory experiments. The use of the dimensionless density ratio allows the expression to predict which sediment‐laden river plumes in lakes and the coastal ocean could quickly form secondary turbidity currents.
Rising: Reverence, Relevance, Revelry — Commemorations of the 1916 Rising in Dublin, Easter 2016
Authors: Averill Ann C. 
Published: August 2019

AbstractThis article describes an empirical study examining the official commemorations of the 1916 Easter Rising, held in Dublin on Easter Sunday, 27 March 2016. Through a combination of newspaper content analysis and empirical data, this study examines the process of generating what Mabel Berezin and Rogers Brubaker have termed ‘communities of feeling’. Analysis of newspaper content between September 2014 and March 2016 highlighted four main themes: (1) a belief that Ireland would have attained sovereignty even if the 1916 Rising had not happened; (2) the equivocal stance of the government towards celebrating the 1916 Rising, which throughout the Northern Ireland troubles habitually presented difficulties for the state; (3) comparisons between commemorating the centenary in 2016 and the jubilee in 1966; and (4) reflections on the purpose of commemorations, particularly the changed emphasis on the role played by women during the Rising as well as the inclusion of religious faiths other than the Catholic Church in such commemorations. The second section of the study provides an analysis of the commemorative events and the nature of contemporary Irish nationalism based on data collected using Non‐Participant Observation. Overall, the study seeks to understand the inter‐connections between nationalism, emotions and social action in the context of Irish nationalism as portrayed during the 1916 commemorations in Dublin.
Auranofin improves overall survival when combined with standard of care in a pilot study involving dogs with osteosarcoma
Authors: Endo‐Munoz Liliana , Bennett Tristram C. , Topkas Eleni , Wu Sherry Y. , Thamm Douglas H. , Brockley Laura , Cooper Maureen , Sommerville Scott , Thomson Maurine , O'Connell Kathleen , Lane Amy , Bird Guy , Peaston Anne , Matigian Nicholas , Straw Rodney C. , Saunders Nicholas A. 
Published: August 2019

AbstractOsteosarcoma is the most common paediatric primary bone malignancy. The major cause of death in osteosarcoma is drug‐resistant pulmonary metastasis. Previous studies have shown that thioredoxin reductase 2 is a driver of metastasis in osteosarcoma and can be inhibited by auranofin (AF). Moreover, studies have shown that AF significantly reduces pulmonary metastases in xenotransplant models. Here, we describe a phase I/II study of AF in canine osteosarcoma, a well‐recognized spontaneous model of human osteosarcoma. We performed a single‐arm multicentre pilot study of AF in combination with standard of care (SOC) (amputation + carboplatin). We recruited 40 dogs to the trial and used a historical SOC‐only control group (n = 26). Dogs >15 kg received 9 mg AF q3d PO and dogs <15 kg received 6 mg q3d. Follow‐up occurred over at least a 3‐year period. Auranofin plus SOC improved overall survival (OS) (P= .036) in all dogs treated. The improved outcome was attributable entirely to improved OS in male dogs (P= .009). At the time of writing, 10 dogs (25%) survive without measurable disease in the treatment group with survival times ranging between 806 and 1525 days. Our study shows that AF improves OS in male dogs when combined with SOC. Our findings have translational relevance for the management of canine and human osteosarcoma. Our data justify a larger multicentre phase 2 trial in dogs and a phase I/II trial in human patients with refractory disease at the time of initial surgery.
Impaired metabolic and hepatic functions following subcutaneous lipectomy in adult obese rats
Authors: El‐Kafoury Bataa M. A. , Bahgat Nehal M. , Abdel‐Hady Enas A. , Samad Abeer A. Abd El , Shawky Mona K. , Mohamed Fatma A. 
Published: August 2019

New Findings
What is the central question of this study?
What is the impact and drawbacks of subcutaneous lipectomy on body metabolism?

What is the main finding and its importance?
Subcutaneous lipectomy resulted in deterioration of hepatic functions, atherosclerotic lipid profile and disturbed redox state. While the results support lipectomy as an effective treatment for obesity, lipectomy induces unfavourable changes in health.

AbstractThe number of obese older adults is on the rise, but data about proper treatment of obesity in the elderly is controversial. The present study was designed to investigate the effectiveness and consequences of partial subcutaneous lipectomy, as a rapid medical intervention against increased accumulation of body fat, in adult obese rats. The study was conducted on adult (9–12 months) female rats, in which obesity was induced by bilateral surgical ovariectomy. They were randomized into two main groups: short term (5 weeks) and long term (10 weeks). Both groups were subdivided into control, ovariectomized (OVX) and ovariectomized lipectomized groups. Body weight (BW) was measured and body mass index (BMI) calculated. Fasting blood glucose, lipid profile and plasma levels of total proteins, albumin, liver enzymes, malondialdehyde (MDA), leptin and adiponectin were determined. The content of both blood and hepatic tissue of reduced glutathione was estimated. In addition, histological study of the liver, aorta and peri‐renal fat was performed. Compared to controls, OVX rats showed significant increase in BW, BMI and plasma levels of liver enzymes, MDA and leptin. Histological study revealed vacuolated ballooned hepatocytes and enlarged irregular visceral adipocytes with atherosclerotic changes in the wall of aorta. Following subcutaneous lipectomy, rats exhibited significant fasting hyperglycaemia, dyslipidaemia, lowered plasma albumin and disturbed redox state with aggravation of the histological changes. The findings indicate that although subcutaneous lipectomy appears to be effective in combating obesity in older females, it has unfavourable effects on both metabolic and hepatic functions.
Steps to better understanding resistant behaviours in hospitalised patients with dementia
Authors: Cook Rob , Lamont Tara , Martin Rosie 
Published: August 2019

The studyFeatherstone K, Northcott A, Harden J, et al. Refusal and resistance to care by people living with dementia being cared for within acute hospital wards: an ethnographic study. Health Serv Deliv Res 2019;7.This study was funded by the National Institute for Health Research Health Services and Delivery Research Programme (project number 13/10/80).To read the full NIHR Signal, go to https://discover.dc.nihr.ac.uk/content/signal-000779/understanding-dementia-care-in-hospitals
Optimising neonatal service provision for preterm babies born between 27 and 31 weeks gestation in England (OPTI-PREM), using national data, qualitative research and economic analysis: a study protocol
Authors: Pillay Thillagavathie , Modi Neena , Rivero-Arias Oliver , Manktelow Brad , Seaton Sarah E , Armstrong Natalie , Draper Elizabeth S , Dawson Kelvin , Paton Alexis , Ismail Abdul Qader Tahir , Yang Miaoqing , Boyle Elaine M 
Published: August 2019

IntroductionIn England, for babies born at 23–26 weeks gestation, care in a neonatal intensive care unit (NICU) as opposed to a local neonatal unit (LNU) improves survival to discharge. This evidence is shaping neonatal health services. In contrast, there is no evidence to guide location of care for the next most vulnerable group (born at 27–31 weeks gestation) whose care is currently spread between 45 NICU and 84 LNU in England. This group represents 12% of preterm births in England and over onr-third of all neonatal unit care days. Compared with those born at 23–26 weeks gestation, they account for four times more admissions and twice as many National Health Service bed days/year.MethodsIn this mixed-methods study, our primary objective is to assess, for babies born at 27–31 weeks gestation and admitted to a neonatal unit in England, whether care in an NICU vs an LNU impacts on survival and key morbidities (up to age 1 year), at each gestational age in weeks. Routinely recorded data extracted from real-time, point-of-care patient management systems held in the National Neonatal Research Database, Hospital Episode Statistics and Office for National Statistics, for January 2014 to December 2018, will be analysed. Secondary objectives are to assess (1) whether differences in care provided, rather than a focus on LNU/NICU designation, drives gestation-specific outcomes, (2) where care is most cost-effective and (3) what parents’ and clinicians' perspectives are on place of care, and how these could guide clinical decision-making. Our findings will be used to develop recommendations, in collaboration with national bodies, to inform clinical practice, commissioning and policy-making. The project is supported by a parent advisory panel and a study steering committee.Ethics and disseminationResearch ethics approval has been obtained (IRAS 212304). Dissemination will be through publication of findings and development of recommendations for care.Trial registration numberNCT02994849andISRCTN74230187.
Effect of ‘lifestyle stigma’ on public support for NHS-provisioned pre-exposure prophylaxis (PrEP) and preventative interventions for HPV and type 2 diabetes: a nationwide UK survey
Authors: Hildebrandt Timothy , Bode Leticia , Ng Jessica S C 
Published: August 2019

ObjectivesThis study examines how the perceived role of poor lifestyle and irresponsible behaviour in contracting HIV, human papilloma virus (HPV) and diabetes affects public support for government-provisioned prevention efforts in Britain. It assesses whether public attitudes on healthcare spending are broadly sensitive to ‘lifestyle stigmas’.MethodsWe conducted an online survey of 738 respondents in Britain and embedded three separate survey experiments to measure support for government-provisioned interventions for HIV, HPV and type 2 diabetes. In each experiment, we manipulated language used to describe the extent to which the diseases are caused by lifestyle choices. Most respondents participated in all three experiments, but assignment was randomised within each condition. Analysis compared support among respondents exposed to ‘lifestyle’ treatment (information emphasising the disease’s lifestyle causes) versus control treatment. We estimated three separate t-tests in which support for government provision of interventions is the dependent variable.ResultsSupport for government-provisioned prevention was high for all three diseases. There was no statistical difference between treatment and control conditions for HIV (treatment mean=3.73, control mean=3.86, p=0.38). But in both HPV (treatment mean=3.96, control mean=4.43, p<0.01) and type 2 diabetes (treatment mean=3.53, control mean=4.03, p<0.01) experiments, support for government-provisioned interventions was significantly lower under lifestyle treatment conditions.ConclusionsPublic opinion on healthcare expenditures in Britain is unexpected and uneven. Consistent participant support for pre-exposure prophylaxis (PrEP) shows public attitudes are not always sensitive to lifestyle stigmas—but for other diseases, perceived relationships between individual behaviour and poor health can still shape public opinion about health expenditures. Policymakers and practitioners should remain attentive to how health problems are framed and discussed to ensure broad public support, and take advantage of policy windows like with PrEP as they may close.
Influenza vaccination in patients with heart failure: a systematic review and meta-analysis of observational studies
Authors: Rodrigues Bárbara Sucena , David Cláudio , Costa João , Ferreira Joaquim J , Pinto Fausto J , Caldeira Daniel 
Published: August 2019

ObjectiveDespite the progression of treatments over decades, heart failure (HF) is a disease with high morbidity, mortality and economic burden. Influenza infection is an important trigger for cardiovascular (CV) events, including HF. Influenza vaccination has been seen to reduce the risk of CV mortality in patients with coronary disease, but the effect in patients with HF is still unclear. Therefore, we conducted a systematic review to evaluate the effect of influenza vaccination in the morbimortality of patients with HF.MethodsMEDLINE, Cochrane Central Register of Controlled Trials, Cochrane Database of Systematic Reviews, Health Technology Assessment and PsycINFO databases (December 2018) were searched for longitudinal studies evaluating influenza vaccination compared with a non-vaccination control group in patients with HF. The risk of bias was assessed according to the ROBINS-I tool. We performed a random-effects meta-analysis to estimate the pooled HRs with 95% CIs, and heterogeneity was evaluated using the I2statistics.ResultsSix cohort studies evaluating 179 158 patients with HF were included in the meta-analysis. Influenza vaccination was associated with a lower risk of all-cause mortality (HR=0.83; 95% CI 0.76 to 0.91; I2=75%). The effect of the influenza vaccination was not statistically significant in a pooled analysis of CV mortality (HR=0.92, 95% CI 0.73 to 1.15; 2 studies) and of all-cause hospitalisations (HR=1.01, 95% CI 0.92 to 1.11; 2 studies). The majority of outcomes in the included studies had a serious risk of bias and almost all evaluated outcomes had very low Grading of Recommendation, Assessment, Development and Evaluation (GRADE) evidence.ConclusionsInfluenza vaccination was associated with a significant decrease in all-cause mortality risk in patients with HF.
Suspected bisphosphate‐related osteonecrosis of the jaw in a cat being treated with alendronate for idiopathic hypercalcaemia
Authors: Rogers‐Smith Emma , Whitley Nat , Elwood Clive , Reese David , Wong Paula 
Published: August 2019

An 8‐year‐old female neutered domestic shorthair diagnosed with idiopathic hypercalcaemia and undergoing weekly treatment with alendronate presented to Davies Veterinary Specialists for progressive facial swelling and discomfort 12 months after commencement of bisphosphonate treatment. Progression of the pathology was documented through clinical history from the referring practice when the patient underwent dental treatment with dental radiographs and then subsequently CT evaluation of the lesions. Proliferative and lytic, multifocal bony changes to the jaw, with a strikingly similar radiographic appearance to that seen in humans suffering from bisphosphonate‐related osteonecrosis of the jaw (BRONJ), were seen. BRONJ is a well‐recognised side effect of bisphosphonate therapy in people undergoing bisphosphonate therapy for the management of malignant hypercalcaemia. The cat was eventually euthanised due to the development of an abdominal mass and declining quality of life.
Structural parameters optimization of a comb-like structure using locally resonant phononic crystals
Authors: Zhai Hongfeng , Xiang Hang , Ma Xingfu , Xiang Jiawei 
Published: August 2019

In this paper, a comb-like locally resonant phononic crystal (LRPC) with optimal structural parameters, which has good low frequency and broadband band gaps (BGs) between 20–250 Hz, is investigated numerically. With the intention of obtaining the optimal structural parameters, based on the structures with different number of the short elastic beams, 2-factor (the two key structural parameters, i.e. the width of the scatterer and the thickness of elastic beams) and 7-level numerical experiments are designed to obtain simulations data using finite element method (FEM). The functional relationships are further constructed using the response surface method (RSM) analysis, i.e. the relationship of the starting frequency of the first BG and the two factors, the terminating frequency of the second BG and the two factors, and the relationship of the total bandwidth of the first two BG and the two factors. After calculation using interior point method, the BGs of LRPC with optimal structural parameters are determined with lower and wider BGs below 250 Hz.
Asymmetric 6-Strand Flexor Tendon Repair – Biomechanical Analysis Using Barbed Suture
Authors: Lee Jasmin Shimin , Wong Yoke-Rung , Tay Shian-Chao 
Published: August 2019

Background: This study investigates the biomechanical performance of the Asymmetric flexor tendon repair technique using barbed suture. The Asymmetric repair technique using monofilament nylon suture was previously reported to have a higher tensile strength than the modified Lim-Tsai repair technique, but its repair stiffness and load to gap force were significantly lower. There is hence an unmet need to improve this technique and the substitution of nylon suture with barbed sutures may be the solution. Methods: Two groups consisting of 10 porcine tendons each were repaired with the six-strand Asymmetric repair technique using V-Loc® 3-0 and Supramid® 4-0 respectively. The repairs were subjected to a mechanical tester for static testing. The ultimate tensile strength, load to 2 mm gap force, repair stiffness, time taken to complete a repair and failure mechanism of the repairs were recorded and analyzed. Results: All the repairs using V-Loc® 3-0 sutures had significantly higher median values of ultimate tensile strength (64.1 N; 56.9 N), load to 2 mm gap force (39.2 N; 19.7 N), repair stiffness (6.4 N/mm; 4.7 N/mm) and time taken to complete a repair (9.4 mins; 7.7 mins). All the repairs using V-Loc® sutures failed by suture breakage while 80% of repairs using Supramid® sutures failed by suture pullout. Conclusions: The use of the barbed sutures in the Asymmetric repair technique, whilst more time consuming, has shown promising improvement to its biomechanical performance (i.e. better ultimate tensile strength, stiffness and resistance to gap formation).
A Comparison of Radiographic Outcomes between 3D Preoperative Planning and Conventional Planning in the Osteosynthesis of Distal Radius Fractures
Authors: Yoshii Yuichi , Totoki Yasukazu , Tung Wen-lin , Akita Kenichi , Ishii Tomoo 
Published: August 2019

Background: To assess the usefulness of three-dimensional (3D) digital pre-operative planning, we compared the radiographic parameters of the distal radius from 3D planning and conventional planning after osteosynthesis of distal radius fractures. We hypothesized that the use of 3D digital planning may improve radiographic outcomes for reduction and decrease the risk of correction loss.Methods: Sixty wrists of 60 distal radius fracture patients were randomly divided into two groups according to the order of hospital visits. Thirty wrists were treated with 3D preoperative planning as the plan group. Another thirty wrists were treated with conventional preoperative planning as the control group. Both groups were treated with volar locking plates. In the plan group, 3D digital preoperative planning and a surgical simulation were performed in order to determine the reduction and placement of the implants in addition to the plate/screw size prior to surgery. In the control group, conventional preoperative planning was performed. Ulnar variance, volar tilt, and radial inclination were measured at one week, three and six months after surgery. Difference of the measurement of radiographic parameters between operated and healthy side wrists were compared between plan and control groups at one week after surgery. Loss of corrections for radiographic parameters were compared between plan and control groups.Results: The differences between the operated and healthy side wrists were significantly smaller in the plan group compared to the control group for the volar tilt and radial inclination (p < 0.05).The loss of corrections for ulnar variance and volar tilt were significantly smaller in the plan group compared to the control group at six months after surgery (p < 0.05).Conclusions: 3D preoperative planning offers better reduction accuracy and reduces correction loss in the osteosynthesis of distal radius fractures.
Post-Exertional MRI Is Useful as a Tool for Diagnosis and Treatment Evaluation for Chronic Exertional Compartment Syndrome of Forearms
Authors: Tominaga Akiko , Shimada Kozo , Temporin Ko , Noguchi Ryosuke 
Published: August 2019

Background: Chronic exertional compartment syndrome (CECS) is a rare condition, which generally occurs in athletes. Few tools are available for diagnosis and treatment evaluation. We examined pre- and post- exertional forearm magnetic resonance imaging (MRI) before and after fasciotomy since 2013. The purpose of this study was to evaluate the efficacy of pre- and post-exertional MRI before and after fasciotomy. Methods: We treated 8 forearms of 5 patients diagnosed with CECS of the forearms since 2013, including 6 forearms of 3 motocross racers, 1 forearm of 1 baseball pitcher, 1 forearm of 1 manual laborer with a history of muscle contusion. We obtained pre- and post-exertional MRI before and after fasciotomy in all cases. Pre-exertional MRI was obtained when the patient was at rest without any symptom. Post-exertional MRI was obtained after the patients repeated “grip and release” using a hand gripper with maximum effort for approximately 10 minutes until symptoms occurred. We compared MRI findings before and after fasciotomy and evaluated the correlation with clinical outcome. Results: Symptoms disappeared completely in all 3 motocross racers after fasciotomy. MRI at rest showed no abnormal high signals in all cases both before and after fasciotomy. On post-exertional MRI, T2 high area presented mainly in flexor digitorum profundus (FDP) and brachioradialis (BR) and disappeared completely after surgery. Symptoms persisted in the pitcher and the laborer after fasciotomy. T2 high area presented mainly in FDP on post-exertional MRI before fasciotomy and remained on post-exertional MRI after fasciotomy in these two patients. These intensity changes correlated strongly with their symptoms. Conclusions: We performed pre- and post-exertional MRI before and after fasciotomy. The intensity change in T2-weighted images on post-exertional MRI correlated strongly with their symptoms. Post-exertional MRI is useful for diagnosis and treatment evaluation in CECS.