bluuebunny/crossref_metadata_2025_split huggingface dataset:
Metabolic Effects of Breaking Prolonged Sitting With Standing or Light Walking in Older South Asians and White Europeans: A Randomized Acute Study
Authors: Yates Thomas , Edwardson Charlotte L , Celis-Morales Carlos , Biddle Stuart J H , Bodicoat Danielle , Davies Melanie J , Esliger Dale , Henson Joe , Kazi Aadil , Khunti Kamesh , Sattar Naveed , Sinclair Alan J , Rowlands Alex , Velayudhan Latha , Zaccardi Francesco , Gill Jason M R 
Published: November 2018

Abstract

Background
Prolonged sitting is common in older adults and is associated with insulin resistance and poor cardiometabolic health. We investigate whether breaking prolonged sitting with regular short bouts of standing or light walking improves postprandial metabolism in older white European and South Asian adults and whether effects are modified by ethnic group.

Methods
Thirty South Asian (15 women) and 30 white European (14 women) older adults (aged 65–79 years) undertook three experimental conditions in random order. (a) Prolonged sitting: continuous sitting during an observation period if 7.5 hours consuming two standardized mixed meals. (b) Standing breaks: sitting interrupted with 5 minutes of standing every 30 minutes (accumulating 60 minutes of standing over the observation period). (c) Walking breaks: sitting interrupted with 5 minutes of self-paced light walking every 30 minutes (accumulating 60 minutes of walking). Blood samples (glucose, insulin, triglycerides) and blood pressure were sampled regularly throughout each condition.

Results
Compared with prolonged sitting, walking breaks lowered postprandial insulin by 16.3 mU/L, (95% CI: 19.7, 22.0) with greater reductions (p = .029) seen in South Asians (22.4 mU/L; 12.4, 32.4) than white Europeans (10.3 mU/L; 5.9, 14.7). Glucose (0.3 mmol/L; 0.1, 0.5) and blood pressure (4 mm Hg; 2, 6), but not triglycerides, were lower with walking breaks, with no ethnic differences. Standing breaks did not improve any outcome.

Conclusions
Breaking prolonged sitting with short bouts of light walking, but not standing, resulted in clinically meaningful improvements in markers of metabolic health in older adults, with South Asians gaining a greater reduction in postprandial insulin.

Trial Registration
NCT02453204
Depression in Later Life: The Role of Adult Children’s College Education for Older Parents’ Mental Health in the United States
Authors: Yahirun Jenjira J , Sheehan Connor M , Mossakowski Krysia N 
Published: November 2018

Abstract

Objectives
Research on the socioeconomic gradient in mental health links disadvantaged family background with subsequent symptoms of depression, demonstrating the “downstream” effect of parental resources on children’s mental health. This study takes a different approach by evaluating the “upstream” influence of adult children’s educational attainment on parents’ depressive symptoms.

Methods
Using longitudinal data from the U.S. Health and Retirement Study (N = 106,517 person-years), we examine whether children’s college attainment influences their parents’ mental health in later life and whether this association increases with parental age. We also assess whether the link between children’s college completion and parents’ depression differs by parents’ own education.

Results
Parents with children who completed college have significantly lower levels of depressive symptoms than parents without college-educated children, although the gap between parents narrows with age. In addition, at baseline, parents with less than a high school education were more positively affected by their children’s college completion than parents who themselves had a college education, a finding which lends support to theories of resource substitution.

Discussion
Offspring education is an overlooked resource that can contribute to mental health disparities among older adults in a country with unequal access to college educations.
Safety Considerations When Working with Humanized Animals
Authors: Villano Jason S , Vleck Susan E , Felt Stephen A , Myers Daniel D , Lester Patrick A 
Published: November 2018

AbstractResearch using laboratory animals has been revolutionized by the creation of humanized animal models, which are immunodeficient animals engrafted with human cells, tissues, or organs. These animal models provide the research community a unique and promising opportunity to mimic a wide variety of disease conditions in humans, from infectious disease to cancer. A vast majority of these models are humanized mice like those injected with human CD34+ hematopoietic stem cells and patient-derived xenografts. With this technology comes the need for the animal research enterprise to understand the inherent and potential risks, such as exposure to bloodborne pathogens, associated with the model development and research applications. Here, we review existing humanized animal models and provide recommendations for their safe use based on regulatory framework and literature. A risk assessment program—from handling the human material to its administration to animals and animal housing—is a necessary initial step in mitigating risks associated with the use of humanized animals in research. Ultimately, establishing institutional policies and guidelines to ensure personnel safety is a legal and ethical responsibility of the research institution as part of the occupational health and safety program and overall animal care and use program.
Inverse J-shaped relation between coronary arterial calcium density and mortality in advanced chronic kidney disease
Authors: Mukai Hideyuki , Dai Lu , Chen Zhimin , Lindholm Bengt , Ripsweden Jonaz , Brismar Torkel B , Heimbürger Olof , Barany Peter , Qureshi Abdul Rashid , Söderberg Magnus , Bäck Magnus , Stenvinkel Peter 
Published: November 2018

Abstract

Background
The coronary artery calcium (CAC) score from cardiac computed tomography (CT) is a composite of CAC volume and CAC density. In the general population, CAC volume is positively and CAC density inversely associated with cardiovascular disease (CVD) events, implying that decreased CAC density reflects atherosclerotic plaque instability. We analysed associations of CAC indices with mortality risk in patients with end-stage renal disease [chronic kidney disease Stage 5 (CKD5)].

Methods
In 296 CKD5 patients undergoing cardiac CT (median age 55 years, 67% male, 19% diabetes, 133 dialysed), the Framingham risk score (FRS), presence of CVD and protein-energy wasting (PEW; subjective global assessment) and high-sensitivity C-reactive protein (hsCRP) and interleukin-6 (IL-6) were determined at baseline. During follow-up for a median of 35 months, 51 patients died and 75 patients underwent renal transplantation. All-cause mortality risk was analysed with competing-risk regression models. Vascular calcification was analysed in biopsies of the arteria epigastrica inferior in 111 patients.

Results
Patients in the middle tertile of CAC density had the highest CAC score, CAC volume, age, CVD, PEW, FRS, hsCRP and IL-6. In competing risk analysis, the middle {subhazard ratio [sHR] 10.7 [95% confidence interval (CI) 2.0–57.3]} and high [sHR 8.9 (95% CI 1.5–51.8)] tertiles of CAC density associated with increased mortality, independent of CAC volume. The high tertile of CAC volume, independent of CAC density, associated with increased mortality [sHR 8.9 (95% CI 1.5–51.8)]. Arterial media calcification was prominent and associated with CAC volume and CAC density.

Conclusions
In CKD5, mortality increased linearly with higher CAC score and CAC volume whereas for CAC density an inverse J-shaped pattern was observed, with the crude mortality rate being highest for the middle tertile of CAC density. CAC volume and CAC density were associated with the extent of arterial media calcification.
Recent developments in endovascular interventions to sustain vascular access patency in haemodialysis patients
Authors: Kitrou Panagiotis , Papasotiriou Marios , Katsanos Konstantinos , Karnabatidis Dimitrios , Goumenos Dimitrios S , Papachristou Evangelos 
Published: November 2018

Abstract
There is amassed evidence regarding the use of endovascular procedures for the treatment of vascular access stenosis and thrombosis. A review was conducted based on available randomized trials, cohort studies and retrospective analyses published after 2000 on endovascular treatment of dysfunctional and thrombosed vascular access, with an aim to illustrate the available device and procedural options. The use of paclitaxel-coated balloons, cutting balloons and covered stents is described in the field of vascular access stenosis. The broad spectrum of available devices and endovascular declotting procedures ranging from thrombolysis to thrombectomy is also discussed. Overall, in this review we demonstrate the increasing role of endovascular procedures in vascular access treatment and the improved patency outcomes provided by the implementation of novel endovascular devices. Moreover, the improvement of post-intervention primary patency rates after endovascular declotting procedures and the shift to more thrombectomy-dependent procedures over time is also highlighted. In conclusion, endovascular treatment of dialysis access stenosis and thrombosis has an established role, owing to the implementation of sophisticated devices, allowing, when needed, the simultaneous treatment of thrombosis and the underlying stenosis.
Long-term blood pressure monitoring by office and 24-h ambulatory blood pressure in renal transplant patients: a longitudinal study
Authors: Mallamaci Francesca , Tripepi Rocco , D'Arrigo Graziella , Porto Gaetana , Versace Maria Carmela , Marino Carmela , Sanguedolce Maria Cristina , Testa Alessandra , Tripepi Giovanni , Zoccali Carmine 
Published: November 2018

Abstract

Background
Renal transplant patients have a high prevalence of nocturnal hypertension, and hypertension misclassification by office blood pressure (BP) is quite common in these patients. The potential impact of hypertension misclassification by office BP on hypertension management in this population has never been analysed.

Methods
We performed a longitudinal study in a cohort of 260 clinically stable renal transplant patients. In all, 785 paired office and 24-h ambulatory blood pressure monitoring (24-hABPM) measurements over a median follow-up of 3.9 years were available in the whole cohort.

Results
A total of 74% of patients had nocturnal hypertension (&gt;120/70 mmHg). Average office BP and 24-hABPM remained quite stable over follow-up, as did the prevalence of nocturnal hypertension, which was 77% at the last observation. However, the global agreement between office BP and average 24 h, daytime and night-time BP was unsatisfactory (k-statistics 0.10–0.26). In 193 visits (25% of all visits) where office BP indicated the need of antihypertensive therapy institution or modification (BP &gt;140/90 mmHg), 24-hABPM was actually normal (&lt;130/80 mmHg), while in 94 visits (12%), 24-hABPM was in the hypertensive range while office BP was normal. Overall, in 37% of visits, office BP provided misleading therapeutic indications.

Conclusions
Hypertension misclassification by office BP is a common phenomenon in stable renal transplant patients on long-term follow-up. Office BP may lead to inappropriate therapeutic decisions in over one-third of follow-up visits in these patients.
Is Smoking Cessation in Young Adults Associated With Tobacco Retailer Availability in Their Activity Space?
Authors: Shareck Martine , Datta Geetanjali D , Vallée Julie , Kestens Yan , Frohlich Katherine L 
Published: November 2018

AbstractIntroductionThe presence of tobacco retailers in residential neighborhoods has been inversely associated with residents’ likelihood of quitting smoking. Few studies have yet explored whether this association holds when accounting for tobacco retailers found in the multiple environments where people conduct their daily activities, that is, their activity space.MethodsWe analyzed cross-sectional data from 921 young adults (18- to 25-years old) participating in the Interdisciplinary Study of Inequalities in Smoking (Montreal, Canada). Respondents self-reported sociodemographic, smoking, and activity location data. Log-binomial regression was used to estimate prevalence ratios (PRs) for the association between smoking cessation and (1) the number of tobacco retailers (counts), and (2) the distance to the closest retailer (proximity) in participants’ residential neighborhood and activity space.ResultsSmoking cessation was positively associated with low and intermediate tertile levels of tobacco retailer counts in both the residential neighborhood and activity space, and with the furthest distance level in the activity space [PR (95% CI) = 1.21 (1.02 to 1.43)].ConclusionsIndividuals encounter resources in the course of their regular daily activities that may hamper smoking cessation. This study highlights the relevance of considering the tobacco retail environment of both individuals’ residential neighborhood and activity space to understand its association with smoking cessation.ImplicationsThis article contributes to the literature on the association between the tobacco retail environment and smoking cessation in young adults by moving beyond the residential neighborhood to also assess individuals’ access to tobacco retailers in the multiple areas where they regularly spend time, that is, their activity space. Findings suggest that lower numbers of tobacco retailers in both the residential neighborhood and activity space, and further distance to tobacco retailers in the activity space are associated with increased smoking cessation.
Upper-Body Exercises With External Resistance Are Well Tolerated and Enhance Muscle Activity in People With Hemophilia
Authors: Calatayud Joaquín , Pérez-Alenda Sofía , Carrasco Juan J , Escriche Adrián , Cruz-Montecinos Carlos , Andersen Lars L , Bonanad Santiago , Querol Felipe , Casaña José 
Published: November 2018

Abstract

Background
Conventional nonresisted therapeutic exercises for people with hemophilia involve a careful, low-intensity approach to avoid injuries. Externally resisted exercise is highly efficient for increasing muscle strength in healthy adults but its feasibility for people with hemophilia remains unknown.

Objective
The purpose of this study was to evaluate muscle activity during upper-body rehabilitation exercises with 2 types of external resistance and without external resistance (conventional) and to examine tolerability, kinesiophobia, and possible adverse effects derived from the session.

Design
This was a cross-sectional study.

Methods
Twelve people with hemophilia A/B (11 with severe hemophilia undergoing prophylactic treatment, 1 with mild hemophilia) participated. During the experimental session, participants completed the Tampa Scale of Kinesiophobia and performed 2 exercises—elbow flexion and shoulder abduction—with 3 conditions for each exercise: elastic resistance (externally resisted), free weights (externally resisted), and conventional nonresisted. Surface electromyography signals were recorded for the biceps brachii, triceps brachii, upper trapezius, and middle deltoid muscles. After the session, exercise tolerability and kinesiophobia were assessed. Adverse effects were evaluated 24 and 48 hours after the session.

Results
Externally resisted exercises provided greater muscle activity than conventional nonresisted therapeutic exercises. The exercises were generally well tolerated and there was no change in kinesiophobia following the session. No adverse effects were observed in the following days.

Limitations
Small sample size was the main limitation.

Conclusions
In people with severe hemophilia undergoing prophylactic treatment, elbow flexion and shoulder abduction exercises with external resistance at moderate intensities are feasible and provide greater muscle activity than nonresisted conventional exercises.
ASSESSMENT OF ANNUAL EFFECTIVE DOSE FROM EXPOSURE TO NATURAL RADIOACTIVITY SOURCES IN A CASE–CONTROL STUDY IN BIHOR COUNTY, ROMANIA
Authors: Dicu T , Burghele B D , Cucoș A , Mishra R , Sapra B K 
Published: November 2018

Abstract
The purpose of the article is to evaluate the annual effective dose for 80 women divided into two samples; one sample located in the former uranium Băiţa-Ştei area, hereinafter referred to as case sample, respectively for a control sample, located in the same county, but exposed in most cases to indoor radon activity concentrations <300 Bq m−3. In this regard, the homemade ‘RaThoGamma’ kit was used, which contained two thermoluminescent dosimeters, a CR-39 track detector (RSKS) for indoor radon activity concentration, two CR-39 track detectors (Radtrak2®/ Radtrak2T®) for radon and thoron activity concentrations as well as Direct Radon Progeny Sensors/Direct Thoron Progeny Sensors for measuring time-averaged radon and thoron progenies concentrations. In addition, a total of 80 water samples were collected in order to evaluate the ingestion dose due to radon and radium activity concentrations in drinking water. The maximum total annual effective dose in the control sample was 14.1 mSv, while in the case sample the maximum annual effective dose was 60.5 mSv. This difference is mainly due to radon progenies inhalation. Other pathways did not show a statistically significant difference between the two samples, showing a minor contribution to the annual effective dose.
Is Schizophrenia a Risk Factor for Breast Cancer?—Evidence From Genetic Data
Authors: Byrne Enda M , Ferreira Manuel A R , Xue Angli , Lindström Sara , Jiang Xia , Yang Jian , Easton Douglas F , Wray Naomi R , Chenevix-Trench Georgia 
Published: November 2018

Abstract
Observational epidemiological studies have found an association between schizophrenia and breast cancer, but it is not known if the relationship is a causal one. We used summary statistics from very large genome-wide association studies of schizophrenia (n = 40675 cases and 64643 controls) and breast cancer (n = 122977 cases and 105974 controls) to investigate whether there is evidence that the association is partly due to shared genetic risk factors and whether there is evidence of a causal relationship. Using LD-score regression, we found that there is a small but significant genetic correlation (rG) between the 2 disorders (rG = 0.14, SE = 0.03, P = 4.75 × 10–8), indicating shared genetic risk factors. Using 142 genetic variants associated with schizophrenia as instrumental variables that are a proxy for having schizophrenia, we estimated a causal effect of schizophrenia on breast cancer on the observed scale as bxy = 0.032 (SE = 0.009, P = 2.3 × 10–4). A 1 SD increase in liability to schizophrenia increases risk of breast cancer 1.09-fold. In contrast, the estimated causal effect of breast cancer on schizophrenia from 191 instruments was not significantly different from zero (bxy = −0.005, SE = 0.012, P = .67). No evidence for pleiotropy was found and adjusting for the effects of smoking or parity did not alter the results. These results provide evidence that the previously observed association is due to schizophrenia causally increasing risk for breast cancer. Genetic variants may provide an avenue to elucidating the mechanism underpinning this relationship.
Interleukin-4/interleukin-13 versus interleukin-5: a comparison of molecular targets in biologic therapy for the treatment of severe asthma
Authors: Wu Albert Y. , Sur Sanjiv , Grant J. Andrew , Tripple Julia W. 
Published: November 2018

Purpose of review
Asthma is a chronic, inflammatory disorder of the airways caused by a complex interplay of various biologic mechanisms. Several monoclonal antibody therapies targeting interleukin (IL)-4/IL-13 and IL-5 cytokine pathways have been developed for the treatment of severe eosinophilic asthma. As individuals can display biomarkers and clinical features characteristic of several asthma phenotypes, selection of anoptimal biologic can be difficult.

Recent findings
Dupilumab, a monoclonal antibody that binds to the α subunit of the IL-4 receptor (IL-4Rα) and has been approved for the treatment of adults with severe atopic dermatitis, has been shown in recent phase 3 trials to also have significant clinical benefits in the asthmatic population irrespective of baseline eosinophil counts.

Summary
As monoclonal antibodies targeting either IL-4 or IL-13 cytokines individually have failed to demonstrate significant clinical benefits, biologics that target cytokine receptors may be more efficacious compared to those that target cytokines. Furthermore, inhibition of the IL-4/IL-13 signaling cascades may disrupt a broader Th2 inflammatory response compared to a more selective impairment of eosinophil proliferation and activity via blockage of the IL-5 pathway. Future research with independently funded, head-to-head trials of approved biologics is needed to elucidate a favorable therapeutic option.
Strategies to reduce corticosteroid-related adverse events in asthma
Authors: Heffler Enrico , Bagnasco Diego , Canonica Giorgio W. 
Published: November 2018

Purpose of review
Severe asthmatics, despite the chronic use of high inhaled corticosteroids (ICS) doses and frequent intake of systemic corticosteroids, remains clinically and/or functionally uncontrolled. These patients are also often affected by rhinitis or chronic rhinosinusitis requiring frequent use of intranasal corticosteroids. Therefore, severe asthmatics are exposed to an overload of corticosteroids that is frequently associated with relevant and costly adverse events. This clinical problem and the strategies to overcome it are here summarized.

Recent findings
Different therapeutic options may help in reducing the corticosteroid load in asthmatics, ranging from allergy immunotherapy (nonsuitable for severe uncontrolled patients), immunosuppressant agents like methotrexate or cyclosporine, novel biologic drugs (mainly anti-IgE, anti-IL5 and anti-IL4-receptor-alpha), and aspirin desensitization (for patients with anti-inflammatory drugs exacerbated respiratory disease).

Summary
The evidence of even serious corticosteroid-related adverse events associated with consistent health-care costs, should prompt the entire scientific community and health regulatory authorities to promote actions to increase the use of well tolerated and effective strategies to reduce the corticosteroid need in asthmatics; the most promising option seems to be the add-on use of biologic agents.