bluuebunny/crossref_metadata_2025_split huggingface dataset:
Lateral Transpsoas Approach for Lumbar Indirect Lateral Recess Decompression: 2-Dimensional Operative Video
Authors: Landriel Federico , Hem Santiago , Yampolsky Claudio 
Published: July 2018

Abstract
Neurogenic claudication is a common symptom of lumbar spinal stenosis; its pathophysiology is thought to be ischemia of the nerve roots secondary to compression from surrounding structures. The stenosis of the lateral recesses and neuroforamen can cause these symptoms and its surgical treatment is decompression. The placement of interbody cages that restore the disc space height may indirectly decompress the neuroforamen and alleviate the nerve impingement symptoms. In case of concomitant low-grade spondylolisthesis, interbody devices might also reduce the slippage. We present a technical surgical video of a minimally invasive lateral transpsoas fusion, relying on indirect decompression to treat a patient with neurogenic claudication secondary to grade 1 spondylolisthesis. The patient signed a written consent to publish a video, recording, photograph, image, illustration, and/or information about him.
Radiosensitivity is an acquired vulnerability of PARPi-resistant BRCA1-deficient tumors
Authors: Barazas Marco , Gasparini Alessia , Huang Yike , Küçükosmanoğlu Asli , Annunziato Stefano , Bouwman Peter , Sol Wendy , Kersbergen Ariena , Proost Natalie , van de Ven Marieke , Jonkers Jos , Borst Gerben , Rottenberg Sven 
Published: July 2018

ABSTRACTThe homologous recombination (HR) defect in BRCA1-associated cancers can be therapeutically exploited by the treatment with DNA-damaging agents and poly (ADP-ribose) polymerase (PARP) inhibitors. We and others previously reported that BRCA1-deficient tumors are initially hypersensitive to the inhibition of topoisomerase I/II and PARP, but acquire drug resistance through restoration of HR activity by the loss of end-resection antagonists of the 53BP1/RIF1/REV7/Shieldin/CST pathway. Here, we identified radiotherapy as an acquired vulnerability of 53BP1;BRCA1-deficient cells in vitro and in vivo. In contrast to the radioresistance caused by HR restoration through BRCA1 reconstitution, HR restoration by 53BP1 pathway inactivation further increases radiosensitivity. This highlights the relevance of this pathway for the repair of radiotherapy-induced damage. Moreover, our data show that BRCA1-mutated tumors that acquired drug resistance due to BRCA1-independent HR restoration can be targeted by radiotherapy.STATEMENT OF SIGNIFICANCEIn this study, we uncovered radiosensitivity as a novel therapeutically exploitable vulnerability of BRCA1-deficient mouse mammary cells that have acquired drug resistance due to the loss of the 53BP1 pathway.
Single-cell chromatin accessibility in glioblastoma delineates cancer stem cell heterogeneity predictive of survival
Authors: Guilhamon P. , Kushida M.M. , Nikolic A. , Singhal D. , MacLeod G. , Madani Tonekaboni S.A. , Cavalli F.M.G. , Arlidge C. , Rajakulendran N. , Rastegar N. , Hao X. , Hassam R. , Smith L.J. , Whetstone H. , Coutinho F.J. , Nadorp B. , Ellestad K.I. , Luchman H.A. , Chan J.A. , Shoichet M.S. , Taylor M.D. , Haibe-Kains B. , Weiss S. , Angers S. , Gallo M. , Dirks P.B. , Lupien M. 
Published: July 2018

ABSTRACTChromatin accessibility discriminates stem from mature cell populations, enabling the identification of primitive stem-like cells in primary tumors, such as Glioblastoma (GBM) where self-renewing cells driving cancer progression and recurrence are prime targets for therapeutic intervention. We show, using single-cell chromatin accessibility, that primary GBMs harbor a heterogeneous self-renewing population whose diversity is captured in patient-derived glioblastoma stem cells (GSCs). In depth characterization of chromatin accessibility in GSCs identifies three GSC states: Reactive, Constructive, and Invasive, each governed by uniquely essential transcription factors and present within GBMs in varying proportions. Orthotopic xenografts reveal that GSC states associate with survival, and identify an invasive GSC signature predictive of low patient survival. Our chromatin-driven characterization of GSC states improves prognostic precision and identifies dependencies to guide combination therapies.
Costing ‘the’ MTD … in 2-D
Authors: Norris David C. 
Published: July 2018

ABSTRACTBackgroundI have previously evaluated the efficiency of one-size-fits-all dosing for single agents in oncology (Norris 2017b). By means of a generic argument based on an Emax-type dose-response model, I showed that one-size-fits-all dosing may roughly halve a drug’s value to society. Since much of the past decade’s ‘innovation’ in oncology dose-finding methodology has involved the development of special methods for combination therapies, a generalization of my earlier investigations to combination dosing seems called-for.MethodsFundamental to my earlier work was the premise that optimal dose is a characteristic of each individual patient, distributed across the population like any other physiologic characteristic such as height. I generalize that principle here to the 2-dimensional setting of combination dosing with drugs A and B, using a copula to build a bivariate joint distribution of (MTDi,A, MTDi,B) from single-agent marginal densities of MTDi,A and MTDi,B, and interpolating ‘toxicity isocontours’ in the (a, b)-plane between the respective monotherapy intercepts. Within this framework, three distinct notional toxicities are elaborated: one specific to drug A, a second specific to drug B, and a third ‘nonspecific’ toxicity clinically attributable to either drug. The dose-response model of (Norris 2017b) is also generalized to this 2-D scenario, with the addition of an interaction term to provide for a complementary effect from combination dosing. A population of 1,000 patients is simulated, and used as a basis to evaluate population-level efficacy of two pragmatic dose-finding designs: a dose-titration method that maximizes dose-intensity subject to tolerability, and the well-known POCRM method for 1-size-fits-all combination-dose finding. Hypothetical ‘oracular’ methods are also evaluated, to define theoretical upper limits of performance for individualized and 1-size-fits-all dosing respectively.ResultsIn our simulation, pragmatic titration attains 89% efficiency relative to theoretically optimal individualized dosing, whereas POCRM attains only 55% efficiency. The passage from oracular individualized dosing to oracular 1-size-fits-all dosing incurs an efficiency loss of 33%, while the parallel passage (within the ‘pragmatic’ realm) from titration to POCRM incurs a loss of 38%.ConclusionsIn light of the 33% figure above, the greater part of POCRM’s 38% efficiency loss relative to titration appears attributable to POCRM’s 1-size-fits-all nature, rather than to any pragmatic difficulties it confronts. Thus, appeals to pragmatic considerations would seem neither to justify the decision to use 1-size-fits-all dose-finding designs, nor to excuse their inefficiencies
Effects of structural and bonding-based attachment on brand loyalty
Authors: Adam Diyawu Rahman , Ofori Kwame Simpe , Okoe Abednego Feehi , Boateng Henry 
Published: July 2018

Purpose
The purpose of this paper is to ascertain the effects of structural and bonding attachment on brand loyalty. The authors identified network quality, network coverage and mobile number portability (MNP) as structural elements of attachment that affect brand loyalty. Similarly, the authors identify brand trust and social interaction ties as elements of bonding-based attachment that affects brand loyalty.

Design/methodology/approach
The authors employed a survey as the research design. There were 500 respondents who were customers of telecommunication network brands in Ghana. Data collected were analyzed using the partial least square approach to structural equation modeling (PLS-SEM) on SmartPLS 3.

Findings
The findings indicate that structural and bonding-based attachments affect the brand loyalty. Specifically, the authors found that network coverage, network quality, brand trust and social interaction ties have positive effects on brand loyalty while MNP has a negative effect on brand loyalty.

Originality/value
This study conceptualizes attachment from both structural and bonding perspectives, which are rare in the marketing literature. Thus, this study advances the conceptualization of attachment in the marketing literature.
Food allergy knowledge, attitudes, and resources of restaurant employees
Authors: McAdams Bruce , Deng Allison , MacLaurin Tanya 
Published: July 2018

Purpose
Restaurants are unique and challenging environments for accommodating food allergies. The purpose of this paper is to evaluate food allergy knowledge, attitudes and resources among restaurant employees, and identify differences based on restaurant mode of operation.

Design/methodology/approach
A total of 209 food-service workers were surveyed in full-service restaurants across Southern Ontario, Canada. A paper-based questionnaire was used to evaluate participants’ food allergy knowledge, attitudes toward handling food allergy requests and emergencies, and the availability of food allergen resources at the restaurant.

Findings
Most participants were knowledgeable about food allergies, and valued being able to provide safe meals. However, there was a general lack of access to important food allergy risk management resources and training. Food allergy attitudes were significantly different between restaurant modes of operation. Also, food allergy training and resources were positively correlated with employee attitudes toward food allergies.

Practical implications
The results of this study show that engaging employees in food allergy training can contribute to greater levels in employee awareness and confidence in protecting health and safety of restaurant patrons with food allergies. Restaurants that demonstrate a strong preparedness toward handling food allergy requests can deliver a better customer experience and increase customer loyalty.

Originality/value
The findings of this study underscore the need for the restaurant industry, policy makers and food safety educators to work together to develop training programs and relevant resources to support and facilitate food allergy risk management in restaurants.
Picking low hanging fruit? Synergies between strategic quality management and corporate social responsibility
Authors: Alsaif Talal Mohammad , Savage Barbara M. , Reed Deborah M. 
Published: July 2018

Purpose
The purpose of this paper is to explore and identify the areas in common between strategic quality management (SQM) and corporate social responsibility (CSR) from the literature. Studying these areas is important to develop any further connection between SQM and CSR because of both the potential for benefit to organisations and society, and in order to minimise resources needed for effective action by capitalising on synergies.

Design/methodology/approach
Literature review covering a broad range of publications that addresses the synergies of quality management and CSR to identify areas of commonality and thus simplify CSR implementation.

Findings
Identification of opportunities for knowledge transfer between SQM and CSR.

Practical implications
Synergies between SQM and CSR may offer attractive opportunities to capitalise on prior actions and learning, to enhance the value added to an organisation and the society in which it operates.

Originality/value
This evaluation is a part of a more in-depth research study investigating the relationship between and integration of SQM and CSR, and its application in specific contexts.
How to turn managers into data-driven decision makers
Authors: Carillo Kevin Daniel André , Galy Nadine , Guthrie Cameron , Vanhems Anne 
Published: July 2018

PurposeThe purpose of this paper is to emphasize the need to engender a positive attitude toward business analytics in order for firms to more effectively transform into data-driven businesses, and for business schools to better prepare future managers.Design/methodology/approachThis paper develops and validates a measurement instrument that captures the attitude toward business statistics, the foundation of business analytics. A multi-stage approach is implemented and the validation is conducted with a sample of 311 students from a business school.FindingsThe instrument has strong psychometric properties. It is designed so that it can be easily extrapolated to professional contexts and extended to the entire domain of business analytics.Research limitations/implicationsAs the advent of a data-driven business world will impact the way organizations function and the way individuals think, work, communicate and interact, it is crucial to engage a transdisciplinary dialogue among domains that have the expertise to help train and transform current and future professionals.Practical implicationsThe contribution provides educators and organizations with a means to measure and monitor attitudes toward statistics, the most anxiogenic component of business analytics. This is a first step in monitoring and developing an analytics mindset in both managers and students.Originality/valueBy demonstrating how the advent of the data-driven business era is transforming the DNA and functioning of organizations, this paper highlights the key importance of changing managers’ and all employees’ (to a lesser extent) mindset and way of thinking.
Service quality for architects: scale development and validation
Authors: Prakash Anand , Phadtare Milind 
Published: July 2018

PurposeThe purpose of this paper is to develop and explain an empirically validated scale to measure service quality for architects in India.Design/methodology/approachThis study applies a systematic procedure for development of a psychometric scale in three phases. Phase 1 includes item generation and selection through review of literature and expert opinion. Phase 2 comprises scale refinement using item analysis and exploratory factor analysis. Phase 3 applies confirmatory factor analysis (CFA) for establishing convergent, discriminant and nomological validity. This study has involved 15 expert participants in Phase 1 and sought participation from 250 respondents using an online questionnaire in two other independent phases.FindingsThe findings of the empirical study resulted in the development of a 22-item scale that measures the constructs such as design quality, project administration quality, communication quality, relationship quality and dependability quality.Research limitations/implicationsThis study has developed a context-specific psychometric scale of service quality for architects in India using snowball sampling. Although this study identified five valid service quality factors, the classified information relating to the formation of expectations was not collected.Practical implicationsThis reliable and valid scale would be helpful for architects to measure the level of service quality in enhancing business performance. This study has established that service quality for architects is achieved only when the perceived benefits are available from the aspects like design, project administration, communication, relationship and dependability.Social implicationsThis study can facilitate an architect interested in opportunities relating to contracting, consulting and engineering to explore possibilities of higher fees from clients.Originality/valueThis study is an original attempt in developing a validated tool to measure service quality of architects in India.
Students’ viewpoints on using tableaux to analyse short stories
Authors: Athiemoolam Logamurthie 
Published: July 2018

Purpose
The purpose of the paper is to provide a detailed account of pre-service teachers’ viewpoints on the use of tableaux as pedagogy to analyse short stories in secondary schools based on their exposure to the use of tableaux and their active participation in the process of tableau creation.

Design/methodology/approach
The study adopted a qualitative approach and a phenomenological design as it provides a detailed account of PGCE English Methodology pre-service teachers’ views on the use of tableaux to teach a short story. The data collection method used was written narratives based on the participants’ detailed accounts of their learning during the process of tableau creation and their viewpoints on the use of such an approach in the teaching of literature within secondary school contexts. The “rich, thick data” extracted from the written narratives were analysed thematically.

Findings
The findings indicated that although pre-service teachers were initially sceptical towards the use of tableaux as a strategy to teach a short story, as they grew in their understanding of the practices involved their insights into the themes, motifs and characters’ emotional, personal and psychological states of being were enhanced.

Originality/value
Research in the use of tableaux as a strategy for pre-service teachers to critically analyse and engage with short stories is a novel approach to teaching and limited research has been conducted in the field.
Experimental investigation of the magnetorheological polishing process with roller
Authors: Song Wanli , Li Hongliang , Ma Jintao , Hu Zhichao , Shi Pei 
Published: July 2018

Purpose
This paper aims to develop a new magnetorheological polishing (MRP) device with roller and investigate the polishing mechanism of MRP fluids using this new device.

Design/methodology/approach
The principle of MRP process with roller is discussed, and then the structure of the polishing device is designed in detail. The polishing experiments of K9 glass are carried out using MRP device with roller.

Findings
A series of tests are performed to evaluate the effect of the excitation gaps, working gap and polishing time on the polishing characteristics, and the optimized polishing parameters can be obtained. The surface roughness Ra of the sample is reduced from 359 to 38 nm under optimized polishing parameters.

Originality/value
MRP method with roller is proposed in this paper, and the MRP device with roller can reduce the surface roughness Ra significantly. After being polished, the circular ring-shaped polishing belt disappears on the workpiece surface, which means it has great potential for polishing.
Are users competent to comply with information security policies? An analysis of professional competence models
Authors: Tsohou Aggeliki , Holtkamp Philipp 
Published: July 2018

Purpose
Information security policies (ISPs) are used by organizations to communicate rules on the use of information systems (IS). Research studies show that compliance with the ISPs is not a straightforward issue and that several factors influence individual behavior toward ISP compliance, such as security awareness or individual perception of security threats. The purpose of this paper is to investigate the competencies associated with users’ ISP compliance behavior.

Design/methodology/approach
In order to reveal the competencies that are associated with the users’ ISP compliance behavior, the authors systematically analyze the ISP compliance literature and the authors develop an ISP compliance competency model. The authors then target to explore if IS users are equipped with these competencies; to do so, the authors analyze professional competence models from various industry sectors and compare the competencies that they include with the developed ISP compliance competencies.

Findings
The authors identify the competencies associated with ISP compliance and the authors provide evidence on the lack of attention in information security responsibilities demonstrated in professional competence frameworks.

Research limitations/implications
ISP compliance research has focused on identifying the antecedents of ISP compliance behavior. The authors offer an ISP compliance competency model and guide researchers in investigating the issue further by focusing on the professional competencies that are necessary for IS users.

Practical implications
The findings offer new contributions to practitioners by highlighting the lack of attention on the information security responsibilities demonstrated in professional competence frameworks. The paper also provides implications for the design of information security awareness programs and information security management systems in organizations.

Originality/value
To the best of the authors’ knowledge, the paper is the first study that addresses ISP compliance behavior from a professional competence perspective.
Software platform establishment: effectuation and entrepreneurial awareness
Authors: Saarikko Ted , Jonsson Katrin , Burström Thommie 
Published: July 2018

PurposeFaced with environments rife with technological uncertainties, software platforms have gained interest as enablers of innovative businesses and development processes. While extant research has focused on mature platforms, the authors know less about the early phases in a platform’s life cycle. Drawing inspiration from the effectual perspective on entrepreneurship, the purpose of this paper is to further the understanding of how software platforms are established.Design/methodology/approachThe authors develop a framework that describes four types of entrepreneurial awareness and then apply it to a qualitative case study of a platform that has emerged from the initial “creation” phase and is now in a period of rapid growth.FindingsThe study indicates that successful establishment of a software platform depends upon the provider’s ability to integrate business acumen with technical proficiency and leverage these combined skills to ensure short-term viability and long-term relevance in the market.Research limitations/implicationsThis paper contributes to literature on platform strategy, which has previously focused on mature platforms, by addressing entrepreneurial behavior during a software platform’s establishment. As it is based on a single qualitative study, additional studies of different platforms are needed to verify the results.Originality/valueThe paper highlights the dependence of software platform establishment on the ability to enact both explorative and exploitative activity patterns, and embrace both strategic foresight and systemic insight cognitive patterns. The combined patterns of activity and cognition form four types of awareness, pertaining to markets, resources, technology and contexts.