bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of Bariatric Surgery on Obese Male Semen Parameters and Reproductive Hormones: a meta-analysis
Authors: Jiang Yu-Li , Qian Lu-Jie , Ye Chun-Hua 
Published: September 2019

Abstract
Background

The relation between bariatric surgery and semen parameters and reproductive hormones on obese male remains incompletely understood.Methods

We searched PUBMED, EMBASE and the Cochrane Central Register for studies from 1999 to 2019 for studies on effect of bariatric surgery on obese male semen parameters and reproductive hormones. Three studies met the inclusion criteria for our meta-analysis. After data extraction and quality assessment, we used RevMan 5.2 to pool the data.Results

Three studies were included in our meta-analysis. The pooled data showed that the testosterone concentration and sperm volume were higher in postoperative group than baseline with a significant difference (WMD:4.63, 95%CI 2.65 to 6.61, P<0.05, WMD; 0.89, 95CI 0.38 to 1.40, P<0.05, respectively). No significant difference was found in the postoperative sperm concentration, sperm morphology, sperm motility and estradiol concentration (WMD: -3.28, 95%CI: -38.86 to 32.29, I2=9%; p=0.89,WMD: -0.52, 95%CI: -5.83 to 4.79, I2=71%; p=0.85, (WMD; -0.01, 95%CI; -5.42 to 5.40, I2=0; p=1.00, WMD: -2.93, 95%CI: -43.11 to 37.24, I2=87%; p=0.89, respectively).Conclusions

Bariatric surgery did not interfere with sperm quality. Our study showed that the postoperation testosterone increased with statistically significance.
The role of probiotics in preventing necrotizing enterocolitis and reducing mortality in neonates: a meta-analysis
Authors: Pan Yu-qing , Hou A-na , Xue Xin-dong , Fu Jian-hua 
Published: September 2019

Abstract
Background: Probiotics are gradually being used as a supplementation to prevent necrotizing enterocolitis (NEC) and reduce mortality in neonates. We performed an updated meta-analysis to systematically evaluate the efficacy and safety of prophylactic probiotic supplementation for preventing NEC.
Methods: The databases including PubMed, EMbase, and China National Knowledge Infrastructure were used to search the relevant articles. The latest retrieval date was up to May 2019. Two reviewers independently screened literature, extracted data, and assessed the risk of bias of the included studies. The meta-analysis was performed using Stata version 10.0.
Results: Finally, a total of 74 studies containing – cases and – controls were included. The results showed that the probiotics could significantly reduce the incidence of NEC (stage II or more) (OR=0.435, 95% CI=0.357-0.530, p<0.001), the overall mortality (OR=0.630, 95% CI=0.491-0.808, p<0.001), and NEC-related mortality (OR=0.639, 95% CI=0.423-0.966, p=0.034).
Conclusion: This meta-analysis indicates that the use of probiotics can effectively reduce the occurrence of NEC and mortality in neonates. These data provide the possible information for the clinical treatment.
O CRIME, O CRIMINOSO E A PENA: O PRECÁRIO QUADRO DA APRECIAÇÃO DA PERSONALIDADE DO AGENTE NA FIXAÇÃO DA PENA BASE NO BRASIL
Authors: Lamas Lívia Paula de Almeida 
Published: September 2019

Este trabalho realiza uma abordagem crítica acerca da análise da personalidade do réu durante a fixação da pena base e os aspectos polêmicos que envolvem tal situação. O objetivo da pesquisa se encontra no fato de que, na fixação da pena base, o legislador deixou um grande espaço para a discricionariedade do juiz, o que pode resultar em interpretações inconstitucionais e violadoras dos direitos e das garantias fundamentais. O trabalho busca demonstrar que, a depender da postura adotada pelo magistrado, a aplicação da pena resultará em uma afronta aos princípios defendidos por um Estado Democrático de Direito.
Recent Advances in Developing K-Ras Plasma Membrane Localization Inhibitors
Authors: Ye Na , Xu Qingfeng , Li Wanwan , Wang Pingyuan , Zhou Jia 
Published: September 2019

:
The Ras proteins play an important role in cell growth, differentiation, proliferation and survival
by regulating diverse signaling pathways. Oncogenic mutant K-Ras is the most frequently mutated
class of Ras superfamily that is highly prevalent in many human cancers. Despite intensive efforts to
combat various K-Ras-mutant-driven cancers, no effective K-Ras-specific inhibitors have yet been approved
for clinical use to date. Since K-Ras proteins must be associated to the plasma membrane for
their function, targeting K-Ras plasma membrane localization represents a logical and potentially tractable
therapeutic approach. Here, we summarize the recent advances in the development of K-Ras plasma
membrane localization inhibitors including natural product-based inhibitors achieved from high
throughput screening, fragment-based drug design, virtual screening, and drug repurposing as well as
hit-to-lead optimizations.
Drug Combinatorial Therapies for the Treatment of KRAS Mutated Lung Cancers
Authors: He Hao , Xu Chang , Cheng Zhao , Qian Xiaoying , Zheng Lei 
Published: September 2019

:KRAS is the most common oncogene to be mutated in lung cancer, and therapeutics directly targeting KRAS have proven to be challenging. The mutations of KRAS are associated with poor prognosis, and resistance to both adjuvant therapy and targeted EGFR TKI. EGFR TKIs provide significant clinical benefit for patients whose tumors bear EGFR mutations. However, tumors with KRAS mutations rarely respond to the EGFR TKI therapy. Thus, combination therapy is essential for the treatment of lung cancers with KRAS mutations. EGFR TKI combined with inhibitors of MAPKs, PI3K/mTOR, HDAC, Wee1, PARP, CDK and Hsp90, even miRNAs and immunotherapy, were reviewed. Although the effects of the combination vary, the combined therapeutics are one of the best options at present to treat KRAS mutant lung cancer.
Automatically Appraising the Credibility of Vaccine-Related Web Pages Shared on Social Media: A Twitter Surveillance Study
Authors: Shah Zubair , Surian Didi , Dyda Amalie , Coiera Enrico , Mandl Kenneth D , Dunn Adam G 
Published: September 2019

Background
Tools used to appraise the credibility of health information are time-consuming to apply and require context-specific expertise, limiting their use for quickly identifying and mitigating the spread of misinformation as it emerges.

Objective
The aim of this study was to estimate the proportion of vaccine-related Twitter posts linked to Web pages of low credibility and measure the potential reach of those posts.

Methods
Sampling from 143,003 unique vaccine-related Web pages shared on Twitter between January 2017 and March 2018, we used a 7-point checklist adapted from validated tools and guidelines to manually appraise the credibility of 474 Web pages. These were used to train several classifiers (random forests, support vector machines, and recurrent neural networks) using the text from a Web page to predict whether the information satisfies each of the 7 criteria. Estimating the credibility of all other Web pages, we used the follower network to estimate potential exposures relative to a credibility score defined by the 7-point checklist.

Results
The best-performing classifiers were able to distinguish between low, medium, and high credibility with an accuracy of 78% and labeled low-credibility Web pages with a precision of over 96%. Across the set of unique Web pages, 11.86% (16,961 of 143,003) were estimated as low credibility and they generated 9.34% (1.64 billion of 17.6 billion) of potential exposures. The 100 most popular links to low credibility Web pages were each potentially seen by an estimated 2 million to 80 million Twitter users globally.

Conclusions
The results indicate that although a small minority of low-credibility Web pages reach a large audience, low-credibility Web pages tend to reach fewer users than other Web pages overall and are more commonly shared within certain subpopulations. An automatic credibility appraisal tool may be useful for finding communities of users at higher risk of exposure to low-credibility vaccine communications.
Differential Diagnosis Assessment in Ambulatory Care With an Automated Medical History–Taking Device: Pilot Randomized Controlled Trial
Authors: Schwitzguebel Adrien Jean-Pierre , Jeckelmann Clarisse , Gavinio Roberto , Levallois Cécile , Benaïm Charles , Spechbach Hervé 
Published: September 2019

Background
Automated medical history–taking devices (AMHTDs) are emerging tools with the potential to increase the quality of medical consultations by providing physicians with an exhaustive, high-quality, standardized anamnesis and differential diagnosis.

Objective
This study aimed to assess the effectiveness of an AMHTD to obtain an accurate differential diagnosis in an outpatient service.

Methods
We conducted a pilot randomized controlled trial involving 59 patients presenting to an emergency outpatient unit and suffering from various conditions affecting the limbs, the back, and the chest wall. Resident physicians were randomized into 2 groups, one assisted by the AMHTD and one without access to the device. For each patient, physicians were asked to establish an exhaustive differential diagnosis based on the anamnesis and clinical examination. In the intervention group, residents read the AMHTD report before performing the anamnesis. In both the groups, a senior physician had to establish a differential diagnosis, considered as the gold standard, independent of the resident’s opinion and AMHTD report.

Results
A total of 29 patients were included in the intervention group and 30 in the control group. Differential diagnosis accuracy was higher in the intervention group (mean 75%, SD 26%) than in the control group (mean 59%, SD 31%; P=.01). Subgroup analysis showed a between-group difference of 3% (83% [17/21]-80% [14/17]) for low complexity cases (1-2 differential diagnoses possible) in favor of the AMHTD (P=.76), 31% (87% [13/15]-56% [18/33]) for intermediate complexity (3 differential diagnoses; P=.02), and 24% (63% [34/54]-39% [14/35]) for high complexity (4-5 differential diagnoses; P=.08). Physicians in the intervention group (mean 4.3, SD 2) had more years of clinical practice compared with the control group (mean 5.5, SD 2; P=.03). Differential diagnosis accuracy was negatively correlated to case complexity (r=0.41; P=.001) and the residents’ years of practice (r=0.04; P=.72). The AMHTD was able to determine 73% (SD 30%) of correct differential diagnoses. Patient satisfaction was good (4.3/5), and 26 of 29 patients (90%) considered that they were able to accurately describe their symptomatology. In 8 of 29 cases (28%), residents considered that the AMHTD helped to establish the differential diagnosis.

Conclusions
The AMHTD allowed physicians to make more accurate differential diagnoses, particularly in complex cases. This could be explained not only by the ability of the AMHTD to make the right diagnoses, but also by the exhaustive anamnesis provided.
Development of MyTeen Text Messaging Program to Support Parents of Adolescents: Qualitative Study
Authors: Chu Joanna Ting Wai , Wadham Angela , Jiang Yannan , Whittaker Robyn , Stasiak Karolina , Shepherd Matthew , Bullen Christopher 
Published: September 2019

Background
Parents play an important role in the lives of adolescents, and supporting and addressing the needs of families continue to be the focus of many researchers and policy makers. Mobile health interventions have great potential for supporting parents at a population level because of their broad reach and convenience. However, limited evidence exists for such interventions for parents of adolescents. This study reports on the formative work conducted with parents and/or primary caregivers to identify their needs and preferences for the development of MyTeen—an SMS text messaging program on promoting parental competence and mental health literacy for parents of adolescents (aged 10-15 years).

Objective
The aim of this qualitative study was to explore parents and/or primary caregivers’ perspectives around youth well-being, parenting, and parenting support and their input on the development of MyTeen SMS text messaging parenting intervention.

Methods
A total of 5 focus groups (n=45) were conducted with parents or primary caregivers of adolescents aged 10 to 15 years between October and December 2017 in New Zealand. A semistructured interview guideline and prompts were used. Data were audiotaped, transcribed, and analyzed using inductive thematic analysis.

Results
Participants were concerned about youth mental health (ie, stigma and increasing demand on adolescents), and a number of parenting challenges (ie, social expectations, time, impact of technology, changes in family communication pattern, and recognizing and talking about mental health issues) were noted. Importantly, participants reported the lack of services and support available for families, and many were not aware of services for parents themselves. A number of recommendations were given on the style, content, and frequency of developing the text messaging program.

Conclusions
Findings from this qualitative work informed the development of MyTeen, an SMS text messaging program designed to increase parental competence and improve mental health literacy for parents of adolescents.
Gambaran Hubungan Regimen Dosis Danefek Samping Kemoterapi pada Pasien Kanker di RSUD Prof Dr. Margono Soekarjo Purwokerto Periode Bulan Januari-Februari Tahun 2019
Authors: Melani Reina , Darmawan Endang , Raharjo Budi 
Published: September 2019

Pengobatan kanker dikenal beberapa cara, salah satunya adalah kemoterapi, yaitu pengobatan dengan menggunakan obat-obatan yang dapat menghambat atau membunuh sel-sel kanker. Pengobatan dengan kemoterapi banyak menimbulkan efek samping. Tujuan penelitian yaitu untuk mengetahui gambaran efek samping kemoterapi pasien kanker di RSUD Prof Dr Margono Soekarjo Purwokerto dan mengetahui hubungan antara regimen dosis terhadap efek samping kemoterapi. Penelitian ini menggunakan rancangan secara prospektif dengan pendekatan study metode cross sectional. Gambaran efek samping kemoterapi yang banyak terjadi di RSUD Prof. Dr Margono Soekarjo Purwokerto pada pasien 10 besar kanker periode bulan Januari – Februari 2019 adalah alergi sebanyak 15 pasien (10%), disusul dengan mual sebanyak 11 pasien (7.3%) sedangkan leukopenia dan neutropenia masing-masing sebanyak 5 pasien (4.7 %). Kesimpulan pada peneltian ini yaitu bahwa ada hubungan yang signifikan antara pemberian obat kemoterapi terhadap terjadinya efek samping setelah menjalani kemoterapi (p< 0,05)
POTENTIAL DRUG-DRUG INTERACTIONS IN HEART FAILURE PATIENTS
Authors: Georgiev Kaloyan , Hvarchanova Nadezhda , Georgieva Marieta , Kanazirev Branimir 
Published: September 2019

Objective: The aim of the present study was to assess the prevalence, risk rating and the severity of hazardous pDDIs (potential drug-drug interactions) in the prescribed pharmacotherapy in the hospital discharged heart failure (HF) patients, primarily with co-administered drugs with narrow therapeutic index (statins, anticoagulants, antithrombotic drugs).
Methods: The prescriptions of chronic heart failure patients for one year (January-December 2014) were analyzed for pDDIs through Lexi-interact® software. DDIs belonging to the categories D (Consider therapy modification) and X (Avoid combination) and/or severity of drug interaction-major, were selected for the study.
Results: After reviewing the medical records of 985 patients, 239 patients were selected based on the criteria mentioned above. The average number of prescription drugs at hospital discharge was 7.27 medications (±1.84 SD) per patient. The total number of pDDIs was 1483 or approximately 6.2 (±3.89 SD) pDDIs per patient. With respect to the risk rating, in categories D and X were detected 76 (5.12 %) and 2 (0.13 %) pDDI, respectively. The major pDDIs were 108 (7.28 %).
Conclusion: HF patients are at high risk of pDDIs. Screening of prescriptions for pDDIs and monitoring of pharmacotherapy in terms of response and associated adverse drug events will contribute to patient safety.
Dr. PI POLYPHENOL CONTENT, PHYTOCHEMISTRY COMPOSITIONS AND ANTIOXIDANT ACTIVITY OF DIFFERENT EXTRACTS FROM MARINE SPONGE AAPTOS SUBERITOIDES GROWN IN NHATRANG BAY, VIETNAM
Authors: XUAN CUONG DANG , BOI VU NGOC , NHAN TRAN KHAC TRI , DONG DINH HUU , QUANG THAI MINH , KIM TRAM PHAM THI , TUYEN DANG THI THANH 
Published: September 2019

Objective: To investigate the content and antioxidant activities of polyphenol, the correlation between polyphenol content and their antioxidant activities, and phytochemistry compositions of different extracts from marine sponge Aaptos suberitoides commonly found growing in Nhatrang bay, Vietnam orienting application into functional food and pharmacy.
Methods: Evaluating the toxicity of antioxidant polyphenol powder preparing from the initial concentrated extract was by the adjusted Behrens Karber method and a correlation between polyphenol content and antioxidant activities basing on the Pearson coefficient in Excel. Separating antioxidant polyphenol content was base on solvents polarization of n-hexane, chloroform, ethanol, ethyl acetate and n-butanol which the quantification of polyphenol content and antioxidant activities, and preliminary phytochemical compositions qualitative.
Results: Antioxidant polyphenol powder did not affect mice weight during the assay time of 28 d. Polyphenol content and antioxidant activities got the highest value at chloroform extract in comparison to other extracts, a significant difference (p<0.05) and strong correlation (R2>0.9). Polyphenol content (122.682 mg gallic acid equivalent ml-1), total antioxidant activity (368.183 mg ascorbic acid equivalent ml-1), reducing power activity (24.08 mg FeSO4 equivalent ml-1) and DPPH scavenging (72.48±1.54 %) were the highest values. Alkaloids, flavonoids, steroids, tannins and triterpenoids existed in initial methanol extract. Weakly polarized polyphenol content was 70.27% in comparison to initial methanol extract.
Conclusion: Antioxidant polyphenol of sponge Aaptos suberitoides has the potential for application into the field of functional food and pharmaceuticals.
Peran Guru dalam Pembentukan Karakter Sosial Anak pada Habib Alby Home Schooling
Authors: Wardati Zahrul 
Published: September 2019

Selama ini pendidikan yang dikembangkan lebih menekankan pada aspek kognitif saja, kurang memperhatikan sisi afektif dan psikomotorik anak. Pelajaran agama seringkali dimaknai secara dangkal dan tekstual, nilai-nilai agama yang ada hanya dihafal dan tidak diamalkan, padahal nilai-nilai religiusitas tidak hanya tampak ketika seseorang melakukan praktek ritual peribadatan saja, seperti shalat, berdo’a, puasa, zakat dan haji. Namun nilai religiusitas nampak pada semua aktifitas keseharian seseorang yang mencerminkan unsur aqidah, ibadah dan akhlak. Homeschooling (Sekolah Rumah) saat ini mulai menjadi salah satu model pilihan orang tua dalam mengarahkan anak-anaknya dalam bidang pendidikan. Pilihan ini muncul karena adanya pandangan para orang tua tentang kesesuaian minat oleh anak-anaknya. Homeschooling ini banyak dilakukan di kota-kota besar.
Dari pengamatan yang peneliti lakukan di Habib Alby yang melakukan salah satu tempat diadakannya homeschooling, peneliti menemukan bahwa guru lebih leluasa dalam mengajarkan peserta didik, sehingga satu guru hanya mengajarkan beberapa peserta didik saja, hal ini akan memudahkan guru tersebut dalam membentuk karakter sosial anak untuk lebih baik.
As vertentes do Jusnaturalismo e a atualidade temática do Direito Natural
Authors: Friede Reis 
Published: September 2019

RESUMOO debate que envolve o Jusnaturalismo e o Juspositivismo tem inspirado as reflexões de juristas e filósofos. Muito embora se possa afirmar que grande parte das históricas controvérsias associadas ao confronto entre o Direito Positivo e o Direito Natural já tenham sido superadas, subsistem inúmeros aspectos que merecem uma dedicação acadêmica. Não obstante opiniões divergentes, as quais pugnam pelo enfraquecimento teórico do assunto, o passar dos séculos demonstra justamente o contrário, posto não ter conseguido eliminar a estima dos pensadores pela temática ora desenvolvida. Deste modo, o presente artigo discorre sobre as diversas vertentes históricas (Cosmológica, Teológica e Racional) do Jusnaturalismo, analisando, ainda, a atualidade temática do Direito Natural.PALAVRAS-CHAVETeoria do Direito. Direito Natural. Jusnaturalismo. Juspositivismo. ABSTRACTThe debate regarding Jusnaturalism and Juspositivism has been inspiring the reflections of jurists and philosophers for a long time. Although it may be affirmed that a great deal of the historical controversies associated to the confrontation between the Positive Law and Natural Law has already been overcome, there are numerous aspects which deserve an academic dedication. Notwithstanding divergent opinions, which struggle for the theoretical weakening of the subject, the passing of the centuries demonstrates precisely the opposite, given that it could not eliminate the esteem of the thinkers for the subject in discussion. Therefore, the current work analyses the characteristics of the various historical strands of Jusnaturalism (Cosmological, Theological and Rational), as well as the current usage of the Natural Law.KEYWORDSLegal theory. Natural Law. Jusnaturalism. Juspositivism.
Liberdade de expressão e ponderação de valores: tutela da dignidade da pessoa humana versus hate speech
Authors: Araújo Jaianny Saionara Macena de , Saraiva Magno Gurgel , Godinho Adriano Marteleto 
Published: September 2019

RESUMOEste trabalho tem como objetivo desenvolver a discussão sobre a liberdade de expressão e seu conflito com o discurso de ódio no ordenamento jurídico brasileiro. Deste modo, expõe-se o entendimento e a dimensão do discurso de ódio, assim como sua resolução diante de casos concretos e a reparação civil pelos danos oriundos. Neste contexto, a Ciência Jurídica não pode ser indiferente ao conteúdo dessas normas, tampouco à sua capacidade de adequação aos problemas sociais. O exercício das liberdades civis, sob este prisma, tem muito a ser enriquecido, à medida que se expande a compreensão – antes eminentemente limitada à esfera normativa privada – e passa a tratar da proteção e garantia de direitos com uma preocupação finalística que deve cuidar evidentemente dos direitos humanos, de sua validade fundada tanto na lei, quanto na Constituição, e de sua real eficácia em favor da dignidade humana.PALAVRAS-CHAVEDireitos Humanos. Direitos Fundamentais. Discurso de ódio. Dignidade da pessoa humana. Liberdade de expressão. ABSTRACTThis paper aims to develop the discussion about freedom of expression and hate speech in the Brazilian legal system. Thus, it shows the concept and dimension of hate speech, as well as the resolution in specific cases and the civil liability for damages. In this sense, Law can’t be indifferent to the content of these rules, neither to its adequation capacity towards the social problems. The exercise of civil liberties, based on this conception, has a lot to be enriched, as far as it expands the understanding – previously limited eminently to the private normative sphere – and moves on to the protection and guarantee of rights with a concern that obviously has to take care of human rights, as well as its real effectiveness in favor of human dignity.KEYWORDSHuman rights. Fundamental rights. Hate speech. Human dignity. Freedom of speech.