bluuebunny/crossref_metadata_2025_split huggingface dataset:
FEVER OF UNKNOWN ORIGIN: DESCRIPTIVE STUDY
Authors: Perova Yu. A. , Ramos Vicente N. , Alandete German L. , Izquierdo Alabau J. , Fernando Lascurain G. , Martinez Mendieta J. , Sanchez Escobedo D. M. 
Published: May 2019

Background: fever of unknown origin is one of the diagnoses more difficult in our area, because it involves monitoring of a complex algorithm of several procedures to establish its cause and con frequently takes too long before any explanation. Therefore, the objective is to get to your diagnosis etiologic and to do a particular series of steps.Objective: to describe the most frequent causes of classical fever of unknown origin in the hospital setting and make a simplified diagnostic search algorithm for this pathology.Methods: a case-series study of 85 patients admitted to the Hospital Obispo Polanco with a diagnosis of fever of unknown origin conducted from 2013 to 2018 in the therapeutic services except for pediatrics and surgery units. The study variables included age, sex, complementary studies (variables from humoral, microbiological and biopsies), results obtained, diagnosis of each patient, treatment.Results: of all patients, 23 (27 %) had infections, of which 14 (16 %) of respiratory focus, 6 (7 %) of urinary focus, 2 (2 %) of abdominal focus and 1 (1 %) of the skin focus. Seven patients (8 %) had neoplasms, three of which (3 %) of respiratory origin, three of digestive tract (3 %) and one of prostatic origin (1 %). In four patients (5 %) were diagnosed of the rheumatic diseases. In 51 (60 %) patients not be could diagnose any cause of fever of unknown origin.Conclusions: the first cause of fever of unknown origin is diseases of unknown etiology with 60 % (51 cases) without being able to identify the clear focus. Among the known etiologies, the most private pathology is infectious bacterial diseases of the respiratory and urinary tracts (27 % — 23 patients). The third place is occupied by oncological diseases with a predominance of malignant pulmonary neoplasms (8 % — 7 patients). Rheumatological diseases occupy the last place and, in this study, accounted for only 5 % (4 patients).
LIPID PROFILE AND HEMORHEOLOGY DYNAMICS IN PATIENTS WITH LOWER EXTREMITY PERIPHERAL ARTERY DISEASE IN THE PREOPERATIVE AND POSTOPERATIVE PERIOD
Authors: Lazarenko V. A. , Bobrovskaya E. A. , Belikov L. N. 
Published: May 2019

The objectiveof the study was to evaluate the lipid and hemostatic profile in patients with peripheral artery disease of lower extremities at different levels of lesion and methods of surgery.Materials and methods.330 male patients with peripheral artery disease of lower extremities arteries of II b — III degree were examined: group I consisted of 140 patients with lesions of the femoral-popliteal arterial segment, who underwent femoralpopliteal bypass surgery (58.64±7.73 years), group II — 97 patients with occlusive-stenotic lesions of the aorto-iliac segment, who underwent aortofemoral bypass surgery (56.82±6.69 years), group III — 93 patients with occlusive stenotic changes of the iliac arteries, who underwent transluminal balloon angioplasty and stenting of the iliac arteries. The examination of patients included general clinical, instrumental and laboratory methods with the assessment of lipid profile fractions and plasma-coagulation level of hemostasis.Results.The provided examination showed that patients with peripheral artery disease have disorders of the blood lipid profile, which have significant differences depending on the severity and localization of occlusive-stenotic lesions of the aorta and main arteries. Lipid imbalance persists after correction of arterial blood flow. Significant changes in the hemostatic profile in all groups in the postoperative period were revealed, which were characterized by hypercoagulation in the form of a significant increase in the concentration of fibrinogen, reducing the activity of antithrombin III, shortening of thrombin time in groups I and II and reducing spontaneous fibrinolysis in groups I and II. Thrombin time and spontaneous fibrinolysis in group III increased relative to preoperative values. Open interventions in the volume of femoral-popliteal bypass surgery were accompanied by a more pronounced inhibition of fibrinolysis in comparison with minimally invasive interventions, and in endovascular procedure the anticoagulant potential was more depressed. Open reconstruction of the iliac segment was associated with a large reduction in thrombin time, but less inhibition of anticoagulant potential, compared with endovascular technique, due to large damage to the endothelium.Conclusion.It is necessary to monitor the lipid and hemostatic profile both before and after surgery in patients, admitted to the hospital for reconstructive surgery on the aorta and main arteries of the lower extremities, in order to develop an effective personalized drug prevention of lower extremity peripheral artery disease progression and to prevent the development of thrombotic and stenotic complications of the arterial reconstruction zone.
IMPULSE OSCILLOMETRY FOR DIAGNOSIS OF EARLY CHANGES IN THE RESPIRATORY SYSTEM FUNCTIONAL STATE IN PATIENTS WITH MILD ASTHMA
Authors: Leontieva N. M. , Demko I. V. , Sobko E. A. , Ishchenko O. P. , Solov’yova I. A. 
Published: May 2019

Currently, the analysis of respiratory function of lungs at suspicion of obstructive pulmonary diseases is recommended to start with spirometry as the most sensitive method of obstruction detection. However, data on informative value and specificity of a method are contradictory. To obtain reliable results good cooperation of the patient and health professionals is necessary. Impulse oscillometry is a noninvasive method of general respiratory resistance assessment, which does not require forced exhalations. The sensitivity and specificity of this method remain undecided as well as the obtained parameter interpretation. Theobjectiveof this work was to study opportunities of impulse oscillometry in diagnostics of early respiratory dysfunctions of ist most informative indicators correlating with parameters of spirometry and body plethysmography.Materials and methods.Patients with the established diagnosis of mild asthma (n=68) were examined. In 71% of patients, obstructive respiratory dysfunction was revealed. In the control group (n=41) there were no abnormalities.Results.In most of patients with revealed via spirometry and body plethysmography obstructive disturbances the increase in indicators of absolute frequency dependence of the resistive component of the respiratory impedance at the oscillation frequency of 5 and 20 Hz (Rrs5-Rrs20) and the reactance area (AX). Increase in Rrs5-Rrs20 was revealed in 48 (71%) patients and the increase in AX was observed in 44 (65%) of the surveyed, patients with 42 (61%) patients without the increase of reactance (Xrs5) and resistance (Rrs5).Conclusion. The absolute frequency dependence of Rrs5-Rrs20 and AX are the most informative parameters of impulse oscillometry. In some patients the IOM findings were more significant in comparison with spirometry ones.
The central mechanism of tadalafil vs Chaihu-Shugan-San capsule for psychogenic erectile dysfunction: a magnetic resonance imaging study protocol of a randomized placebo-controlled trial
Authors: Ren Feiqiang , Ma Ziyang , Zhang Ling , Dong Liang , Chen Diang , Chang Degui , Zhang Peihai , Li Guangsen , Huang Xiaopeng , You Yaodong , Yu Xujun , Yang Fang , Li Zhengjie 
Published: May 2019

Abstract
Background: Erectile dysfunction (ED) affects many adult men worldwide. Many studies on the brain of psychogenic ED have shown significant cerebral functional changes and reduced volume of gray matter and white matter microstructural alterations in widespread brain regions. We design this study to provide both an enhanced level of evidence of central mechanism research and an evidence-based treatment option for patients suffering from psychogenic ED. Furthermore, we also aim to provide a new evidence as well as an innovation of the clinical treatment in psychogenic ED.
Method and Analysis: This study is designed as a multi-center, three-arms, randomized trial. From the perspective of psychogenic ED, we will divide patients into three groups, which are placebo group, tadalafil group and CHSGS group. 135 patients will be randomly allocated to receive placebo, CHSGS capsule or tadalafil oral pharmacotherapy. After the period of 4-week treatment, the outcome of primary assessment changes in the IIEF-5, EHS and QEQ total scores from baseline. Secondary assessments include the SEAR, HAMA-14, HAMD-17 scores, response rate of the patients and their partners. Apart from brain MRI from baseline, we will also attach great importance to other changes in the follow-up four weeks.
Discussion: We expect that the results of this trial can provide both an enhanced level of evidence for central mechanism research and an evidence-based treatment option for patients suffering from ED, as well as to provide an innovation of the clinical treatment in psychogenic ED.
Cognitive impairments in patients with persistent symptoms attributed to Lyme disease
Authors: Berende Anneleen , Rentergem Joost Agelink van , Evers Andrea W. M. , Hofstede Hadewych J. M. ter , Vos Fidel J. , Kullberg Bart Jan , Kessels Roy P.C. 
Published: May 2019

Abstract
Background:
Persistent symptoms attributed to Lyme borreliosis often include self-reported cognitive impairment. However, it remains unclear whether these symptoms can be substantiated by objective cognitive testing.

Methods:
For this observational study, cognitive performance was assessed in 280 adults with persistent symptoms attributed to Lyme borreliosis (as part of baseline data collected for the Dutch PLEASE study). Cognitive testing covered the five major domains: episodic memory, attention, verbal fluency, information-processing speed and executive function. Patients’ profiles of test scores were compared to a large age-, education- and sex-adjusted normative sample using multivariate normative comparison. Performance validity was assessed to detect suboptimal effort, and questionnaires were administered to measure self-reported cognitive complaints, fatigue, anxiety, depressive symptoms and several other psychological factors.

Results:
Of 280 patients, one was excluded as the test battery could not be completed. Of the remaining 279 patients, 239 (85.4%) displayed sufficient performance validity. Patients with insufficient performance validity felt significantly more helpless and physically fatigued, and less orientated. Furthermore, they had a lower education level and less often paid work. Of the total study cohort 5.7% (n=16) performed in the impaired range. Among patients who displayed sufficient performance validity, 2.9% (n=7) were classified as cognitively impaired. No association between subjective cognitive symptoms and objective impairment was found.

Conclusions:
Only a small percentage of patients with borreliosis-attributed persistent symptoms have objective cognitive impairment. Performance validity should be taken into account in neuropsychological examinations of these patients. Self-report questionnaires are insufficiently valid to diagnose cognitive impairment.
An assessment of the level of awareness of e-health among Saudi medical students
Authors: Aldebasi Bader , Alhassan Abdulaziz I. , Al-Nasser Sami , Abolfotouh Mostafa A. 
Published: May 2019

Abstract
Background: Previous studies described the levels of awareness of patients and health care providers on e-health in general and on e-health for a certain condition/disease. However, none of these studies was conducted in Saudi Arabia. The aims of this study were 1)To determine the levels of knowledge, attitude and practice of medical students on e-health, and 2) To identify the predictors of e-health practice among medical students. Methods: A cross-sectional survey of 440 medical students at the college of medicine, King Saud bin-Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia, was conducted, during October/November 2019, using a previously validated questionnaire, to assess: (1) knowledge in three domains; e-health definition (13 statements), fields of application of e-health (8 statements), methods of using e-health (7 statements), (2) attitude toward using e-health (8 statements) and (3) reported practice of e-health in medical training (5 statements). A scoring system was used to calculate the total and percentage score of knowledge, attitude and practice for each student. Multiple regression analysis was applied to identify predictors of e-health practice. Significance was considered at p<0.05. Results: Of the 440 medical students surveyed, the majority were females (55.7%), of stream type1 (79.8%) and from families whose monthly income was more than 10,000SR (82.8%). Overall knowledge about e-health was unsatisfactory (PMS=71.62%), with only 43.6% of all students reporting satisfactory level. However, this level was satisfactory for fields of application (Percentage mean score-PMS=76.43%) and unsatisfactory for definition of e-health (PMS=70.69%) and methods of its use (PMS=65.69%) domains. Overall attitude towads e-health use was positive (PMS=82.32%), with nearly three-quarters of all students (73.4%) reporting positive attitude. Generally, good level of practice of e-health was reported by students (PMS=84.27%), with more than three-quarters of medical students (78.4%) reporting good practice. Adjusting for age, gender, stream, educational grade and family monthly income, good practice was significantly predicted with higher knowledge (t=2.219, p=0.027) and attidude (t=2.114, p=0.035) scores. Conclusion: This study provides basic information regarding medical students’ knowledge, attitude, and practice on e-health. More resources should be directed to elevate medical students’ knowledge and to motivate them to practice e-health using the available tools.
The Problem of Cultural Identity in the Contemporary Archaeological Practice
Authors: Kuzmanović Zorica 
Published: May 2019

The decades-long reconsideration of the concept of culture in archaeology has been aimed at overcoming the traditional culture-historical concept, assuming culture as a relatively stable and homogeneous system of values characteristic of a certain group or a community of people. The practice of cultural classification of artefacts, based upon the premise that people linked by the production and usage of stylistically homogeneous material culture form a group with the feeling of communal identity, has been criticized as a reflection of ethnocentric projection of the modern idea of cultural identity.
In spite of numerous critics of this concept, developed under the influence of various theoretical strains from the beginning of the 1960s, it seems that the implicit assumption is still present of the communal cultural identity of a group linked by the communal material culture. Furthermore, an attempt to counteract the critique and offer a multicultural interpretation of the past brings in the danger to rehabilitate the very concept of culture which archaeology has been trying to abandon for decades.
Savage Man as the Measure of Alterity
Authors: Milosavljević Monika 
Published: May 2019

The notion of savage man came into being through one of the most vital issues raised by the people in the past – that of humanity. Even in the most ancient written sources, savage man is introduced as a defining notion of the demarcation between the world of humans and the world of animals. On the other hand, this notion can be taken as a relational phenomenon of imagination, whose chronological changes are indicative of the reverse side of “normality” under various social circumstances. The subject of this paper is the idea of savage man as the Other in the history of archaeological ideas. The idea entered archaeology along with the concept of savagery, by which anthropology ensured the position of allochronic discourse among scientific disciplines – the science about other people in other times. Since the “ethnographic present” has remained an important frame of reference for archaeological investigation, the idea of savage man has been directing archaeological interpretations of the culturally and chronologically most distant European pasts. The aim of the paper is to reconsider the mechanisms by which the humanities, applying the myth of savage man, enforce the modern European identity as opposed to the Others in space and time. The ideas of savage man will be explored in the context of Late Mediaeval and early modern societies, as the means for interpretation of identities in the past. After the postcolonial critique, this approach offers the model for understanding the ways in which communities in the past thought their own identities as opposed to imagined (non)humanity, but also how these imagined constructs influenced certain social practices recognizable in the archaeological record.
Immigration Discourse in the British Press: Peculiarities of Construction
Authors: Matytsina M. S. 
Published: May 2019

The present research features immigration discourse published in the Daily Mail. The author believes immigration discourse to be a consequence of the so-called Arab Spring of 2011. The paper describes some peculiarities of the discourse related to the events of 2011, its semantic indicators, and some particular examples. According to the critical discourse analysis, discourse is a form of social interaction, which makes it possible to clarify how ideology sets the formatting rules of discourse and determines its content. The relevance of the study is due to the growing scientific interest to the phenomenon of political discourse and its various aspects. The research revealed non-politicized terminology that represents immigrants as helpless, desperate victims, who are described with the help of "humanitarian" concepts when it goes about immigration control measures. However, the humanization and victimization of immigrants act as a justification for the measures taken to combat "illegal" immigration and the "humanitarian rescue" of citizens in danger.
Alpha Adducin (ADD1) Gene Polymorphism and New Onset of Diabetes Under the Influence of Selective Antihypertensive Therapy in Essential Hypertension
Authors: Gupta Sumeet , Jhawat Vikas , Agarwal Bimal Kumar , Roy Partha , Saini Vipin 
Published: May 2019

Background:
Different antihypertensive therapies (especially diuretics) are reported to
induce the new onset of diabetes in some hypertensive patients. α-adducin-1 (ADD1) gene is salt
sensitive gene which has its role in etiology of hypertension via salt sensitivity. Therefore, the
G460T polymorphism of ADD1 gene may be associated with new onset of diabetes under the influence
of diuretic and other antihypertensive therapies.

Aim:
To assess the correlation between genetic polymorphism (ADD1 G460T polymorphism) and
glycaemic disturbance under influence of diuretic and other antihypertensive drug therapies.

Materials and Methods::
We recruited study subjects, 270 normotensive as control (150 male and
120 females), 270 hypertensive patients (95 male and 175 females) and 240 hypertensive with new
onset of diabetes patients (80 male and 160 females). All study samples were genotyped for ADD1
polymorphic alleles and analyzed the relationship between different genotypes with respect to anthropometric
and clinical parameters along with drug therapies.

Results:
Clinical and anthropometric parameters (such as age, SBP, DBP, FBG, height, weight,
WC, HP, W/H ratio, and BMI) of study population were found highly statistically significant
(p<0.05) at base value. Further, genotype wise comparison of all the above parameters revealed
most of them as non-significant (p>0.05). Whereas, comparison between genotype and different
antihypertensive drug therapy of hypertensive patients, specifically, diuretic therapy as mono in
male (p=0.0227) and female (p=0.0292) and in combination with BBs in both male (p=0.0023) and
female (p=0.0079) revealed a higher FBG level in variant T allele. In case of hypertensive with new
onset of diabetes patients, only female population showed a slightly statistically significant
(p=0.0413) difference in FBG level with diuretic mono therapy. Other antihypertensive drug therapies
were safe and effective either as mono or in combination therapy.

Discussion:
Anthropometric parameters may be the indicative factors for hypertension and diabetes.
Variant T allele of ADD1 gene may be considered as the risk factor for the development of
diabetes in hypertensive patients. Diuretics as mono therapy and in combination with BBs may be
considered as the risk factor for new onset of diabetes in EH patients carrying variant T allele (either
as TG or TT).
A interseccionalidade de gênero, raça e classe em livros didáticos de EJA
Authors: Silva Márcia Alves da , Pinheiro Renata Kabke 
Published: May 2019

Esta escrita apresenta algumas análises que fazem parte de uma pesquisa maior. Aqui são apresentadas análises de alguns livros pertencentes a uma coleção de livros didáticos voltada à educação de jovens e adultos nos anos finais do Ensino Fundamental. Essa coleção foi aprovada pelo Plano Nacional do Livro Didático (PNLD) e indicada para os anos 2014, 2015 e 2016. Em um primeiro momento, o texto traz um pequeno histórico dos programas de livros didáticos no país para, em um segundo momento, trazer a abordagem dos livros analisados. A intenção é problematizar as representações de gênero que os livros didáticos carregam, compreendendo gênero na sua interseccionalidade com raça e classe social. Em nossa investigação, é possível perceber que, mesmo com os avanços na legislação sobre o tema e da política de avaliação dos livros didáticos, implementada já há algum tempo, e ainda que se percebam avanços no que se refere ao combate à discriminação de gênero, raça e classe, persistem abordagens conservadoras e discriminatórias, mesmo que de forma bastante sutil, o que demonstra a naturalização de desigualdades sociais.
Hazard identification, risk assesment and risk control serta penerapan risk mapping pada rumah sakit hewan Prof. Soeparwi Universitas Gadjah Mada
Authors: Pertiwi Pertiwi , Nurhantari Yudha , Budihardjo Santosa 
Published: May 2019

Hazard identification, risk assesment and risk control and the application of risk mapping at Hospital of the Animal Prof. Soeparwi Universitas Gadjah Mada Purpose: This research was held to analyze the work accident using HIRARC method and the applied of Risk Mapping at the hospital of the animal of Prof. Soeparwi Gadjah Mada University, Yogyakarta.Method: This research used descriptive qualitative research method. The qualitative method used to describe the condition, assess, and to recognize the work accident analysis. The data used was grabbed from Hazard Identification Risk Assessment and Risk Control (HIRARC) method and questionnaire.Results: Hazard identification used HIRARC method at the hospital of the animal of Prof. Soeparwi Gadjah Mada University was about 198. The work hazard commonly includes physical hazard, chemistry, biologist, ergonomics, and psychosocial. The risk assessment which held denoted that there were 61 low risks, 108 medium risks, and 15 high risks. The recommendations of risk restraint that can be given were technician control, administrative, and the use of personal protective equipment (PPE).Conclusion: HIRARC method had been applied at the hospital of animal of Prof. Soeparwi with the result to that grooming unit was high risk work place, assessed with risk mapping. The risk was from animal contact phisically.