bluuebunny/crossref_metadata_2025_split huggingface dataset:
Delivery of a TNF‐α–derived peptide by nanoparticles enhances its antitumor activity by inducing cell‐cycle arrest and caspase‐dependent apoptosis
Authors: Yan Qiuxia , Chen Xueming , Gong Huizhen , Qiu Pei , Xiao Xing , Dang Shiying , Hong An , Ma Yi 
Published: August 2018

ABSTRACTProstate cancer is the second‐most common malignancy of the male genitourinary system. TNF‐α has attracted intense attention as a potential therapeutic agent against various cancers. However, its therapeutic application is restricted by short half life and severe toxic side‐effects. In this study, we constructed a stable nanodrug called TNF‐α–derived polypeptide (P16)‐conjugated, chitosan (CTS)‐modified selenium nanoparticle (SC; SCP), which is composed of SC as a slow‐release carrier conjugated to P16. SCP had significant inhibitory effects on multiple types of tumor cells, especially DU145 prostate cancer cells, but not on RWPE‐1 normal human prostate epithelial cells. SCP could induce G0/G1 cell‐cycle arrest and apoptosis in DU145 cells more effectively than could P16 and TNF‐α. In DU145 xenograft tumor models, SCP exerted much stronger antitumor effects than P16 or estramustine (the clinical drug for prostate cancer) but caused fewer toxic side‐effects. In addition, SCP significantly inhibited proliferation and accelerated apoptosis in DU145 xenograft tumors. Further mechanistic studies revealed that SCP exerted antitumor effects via activation of the p38 MAPK/JNK pathway, thus inducing G0/G1 cell‐cycle arrest and caspase‐dependent apoptosis. These findings suggest that SCP may represent a potential long‐lasting therapeutic agent for human prostate cancer with fewer side effects.—Yan, Q., Chen, X., Gong H., Qiu, P., Xiao, X., Dang S., Hong A., Ma, Y. Delivery of a TNF‐α–derived peptide by nanoparticles enhances its antitumor activity by inducing cell‐cycle arrest and caspase‐dependent apoptosis. FASEB J. 32, 6948–6964 (2018). www.fasebj.org
A Case of Late Spontaneous Post–Radial Keratotomy Corneal Perforation Managed With Specialty Lenses
Authors: Van den Heurck Jonas , Boven Kim , Anthonissen Lieselotte , Van Hoey Maarten , Koppen Carina 
Published: August 2018

Purpose:
To describe a case of spontaneous wound dehiscence 29 years after radial keratotomy (RK) and to illustrate how specialty contact lenses were used for tectonic support and optic correction.

Setting:
Tertiary referral center for corneal pathology.

Design:
Case report.

Results:
In November 2014, a 62-year-old woman presented to the emergency department with a spontaneous corneal perforation in her left eye. Her ocular history was significant only for uncomplicated RK surgery performed in 1985 to correct myopia (−5.50 D) in both eyes. At the slit-lamp pronounced, bullous edema was seen in the inferotemporal quadrant of the left cornea with internal opening of the 3.30- and 5-o'clock positions incisions and severe localized thinning and aqueous leakage at the 5-o'clock position incision. There was no history of trauma. A conservative approach was adopted: application of a standard bandage lens was effective in tamponading the leakage, allowing the anterior chamber to reform; a custom-made soft lens was worn for tectonic support over a period of 4 months. Finally, visual acuity was restored to 20/20—by fitting a scleral lens.

Conclusion:
Spontaneous corneal perforation is a rare but more dramatic long-term complication after RK. The pivotal role of appropriately fitted soft bandage lenses in the conservative management of this type of complex perforation is highlighted. For optical correction, a scleral lens was fitted with excellent visual result, illustrating the added value of specialty contact lenses as an alternative to surgery in the management of postrefractive corneas.
Hematopoietic stem cell transplantation for autoimmune diseases: more than just prolonged immunosuppression
Authors: Tyndall Alan 
Published: August 2018

Purpose of review
To summarize the current clinical experience in the use of autologous hematopoietic stem cell transplantation (HSCT) in autoimmune disease and to explore the concept of durable remission induction and tissue de-remodeling via restoration of normal niche function and “immune reset."

Recent findings
Controlled clinical trials in systemic sclerosis, multiple sclerosis, and Crohn's disease as well as extensive uncontrolled trial and registry data have established the unique role of HSCT in selected cases. Although HSCT for multiple sclerosis and systemic sclerosis has recently entered several official treatment guidelines, mechanistic studies are few but indicate some possible modes of action, for example, increase of regulatory T cells. Toxicity of HSCT remains high but is improving with protocol modifications and more precise patient selection.

Summary
For the first time, it has been demonstrated that strategies exist which may permanently reprogram an autoaggressive immune system to one of self-tolerance independent of ongoing immunosuppression. In addition, some tissues have the capacity to repair damage via normal regenerative processes. The exact mechanism(s) as to how this is achieved in certain cases and not others are emerging. Such knowledge, together with adoption of recently developed less toxic and more targeted regimens from the hematology/oncology field may translate to a safer yet still effective treatment for autoimmune disease.
Construct Validity of the Multi-Source Interference Task to Examine Attention in Heart Failure
Authors: Jung Miyeon , Jonides John , Berman Marc G. , Northouse Laurel , Koelling Todd M. , Pressler Susan J. 
Published: August 2018

Background
Patients with heart failure (HF) are at risk of cognitive dysfunction, including decreased directed attention. Directed attention is critical for performing daily activities including HF self-care by facilitating one to follow instructions or train-of-thought when there are interferences in which presented stimuli are in conflict with one another. The Multi-Source Interference Task (MSIT) is a computerized neuropsychological test that examines the function of the dorsal anterior cingulate cortex, the neurological substrate for directed attention. However, the MSIT has not been used in past HF studies.

Objective
The purpose of the study was to examine construct validity of the MSIT in HF.

Methods
Baseline data were obtained from a cognitive intervention study among patients with HF (n = 22) and age- and education-matched healthy adults (n = 20). Construct validity was evaluated using t tests to examine differences between patients with HF and healthy adults and congruent and incongruent MSIT trials. Pearson’s correlations were computed to examine relationships between the MSIT and Trail-Making Test, Stroop Test, and Attentional Function Index.

Results
Compared with healthy adults, patients with HF demonstrated worse performance (i.e., slower response times and higher error rates) on MSIT. Patients with HF had worse performance on MSIT incongruent trials than congruent trials. Interference z scores of MSIT did not correlate with Trail-Making Tests A and B and Stroop Test interference z scores, but the MSIT interference z scores correlated with perceived attention function measured by Attentional Function Index.

Discussion
Construct validity of the MSIT was supported, in part, among patients with HF. The MSIT is a sensitive measure of detecting worse directed attention among patients with HF compared with healthy adults. The preliminary findings support the use of the MSIT as a measure of directed attention in HF. Confirmation is warranted for current findings in larger samples.
Machine Learning Methods for Identifying Critical Data Elements in Nursing Documentation
Authors: Bose Eliezer , Maganti Sasank , Bowles Kathryn H. , Brueshoff Bonnie L. , Monsen Karen A. 
Published: August 2018

BackgroundPublic health nurses (PHNs) engage in home visiting services and documentation of care services for at-risk clients. To increase efficiency and decrease documentation burden, it would be useful for PHNs to identify critical data elements most associated with patient care priorities and outcomes. Machine learning techniques can aid in retrospective identification of critical data elements.ObjectiveWe used two different machine learning feature selection techniques of minimum redundancy–maximum relevance (mRMR) and LASSO (least absolute shrinkage and selection operator) and elastic net regularized generalized linear model (glmnetin R).MethodsWe demonstrated application of these techniques on the Omaha System database of 205 data elements (features) with a cohort of 756 family home visiting clients who received at least one visit from PHNs in a local Midwest public health agency. A dichotomous maternal risk index served as the outcome for feature selection.ApplicationUsingmRMRas a feature selection technique, out of 206 features, 50 features were selected with scores greater than zero, and generalized linear model applied on the 50 features achieved highest accuracy of 86.2% on a held-out test set. Usingglmnetas a feature selection technique and obtaining feature importance, 63 features had importance scores greater than zero, and generalized linear model applied on them achieved the highest accuracy of 95.5% on a held-out test set.DiscussionFeature selection techniques show promise toward reducing public health nursing documentation burden by identifying the most critical data elements needed to predict risk status. Further studies to refine the process of feature selection can aid in informing PHNs’ focus on client-specific and targeted interventions in the delivery of care.
Evidence in Rehabilitation Medicine
Authors: Negrini Stefano 
Published: August 2018

AbstractThe relationship between evidence-based medicine and rehabilitation medicine is somewhat controversial. The motto “there is no evidence in rehabilitation medicine” is at times a real burden on the shoulders of rehabilitation medicine. There are many ideas around evidence in rehabilitation medicine; some are correct, whereas others are probably prejudices only. In this article, it is first discussed what evidence is, its origin and meaning, giving some notes about Cochrane—arguably, the criterion standard of evidence medicine. The relationship between rehabilitation medicine and evidence is then faced, to try to understand why these difficulties exist; it is considered what rehabilitation medicine is, comparing rehabilitation medicine with the other “classical” medical specialties; the problems with evidence generation and the actual state of research in rehabilitation medicine. The implementation of evidence in rehabilitation medicine is also introduced, including a brief discussion of knowledge translation, what it is, and why it is important, paying particular attention to Cochrane Rehabilitation—the new global rehabilitation medicine body that is facing these issues. Finally, some solutions for evidence in rehabilitation medicine are proposed.
Pure Skin Perforator Flaps: The Anatomical Vascularity of the Superthin Flap
Authors: Narushima Mitsunaga , Yamasoba Tatsuya , Iida Takuya , Matsumoto Yu , Yamamoto Takumi , Yoshimatsu Hidehiko , Timothy Shim , Pafitanis Georgios , Yamashita Shuji , Koshima Isao 
Published: August 2018

Background:
Recently, a superthin “pure skin perforator” flap without any subcutaneous tissue was proposed, but the vascularity is still unclear. The authors therefore investigated the vascularity of the proposed superficial circumflex iliac artery–pure skin perforator along with its clinical applications and findings on indocyanine green imaging.

Methods:
The locations and dimension of 70 pure skin perforators on 40 flaps were investigated and classified into central-peripheral and mediolateral parts. Indocyanine green angiography was used to analyze the patterns of the vascular anatomy.

Results:
Twenty-seven of 29 cases (93.1 percent) presented with pure skin perforator vessels within the area 5 cm above and 1 cm below the inguinal ligament and 4 cm medial and 2 cm lateral from the anterior superior iliac spine. The total flap size averaged 39 ± 22 cm2 (range, 3 to 90 cm2). A subanalysis of the relationship between the flap size and location of pure skin perforators within the single, double, and triple pure skin perforator flap subgroups did not reveal any significance. Indocyanine green angiography revealed three interesting perfusion patterns of pure skin perforator flap: a radial diffusion pattern, direct linking vessels in the intradermal layer, and intradermal arteriovenous shunts.

Conclusions:
The location number of the pure skin perforators within the flap was not considered to be a crucial factor in the flap design and size in this study. This new knowledge regarding the pure skin perforator concept will allow surgeons to elevate a full-thickness skin flap safely.
Subclinical Changes in Deceased Donor Kidney Proteomes Are Associated With 12-month Allograft Function Posttransplantation—A Preliminary Study
Authors: Kaisar Maria , van Dullemen Leon , Charles Philip , Akhtar Zeeshan M. , Thézénas Marie L. , Huang Honglei , Klooster Astrid , Watkins Nicholas A. , Kessler Benedikt , Ploeg Rutger J. 
Published: August 2018

Background
Cerebral injury during donation after brain death may induce systemic damage affecting long-term kidney function posttransplantation. Conventional evaluation of donor organ quality as a triage for transplantation is of limited utility.

Methods
We compared donor kidneys yielding opposing extremes of the continuum of posttransplantation outcomes by several common kidney biopsy evaluation techniques, including Kidney Donor Profile Index and Remuzzi scoring, and analyzed tissue from a minimal sample cohort using label-free quantitation mass spectrometry. Further assessment of the proteomic results was performed by orthogonal quantitative comparisons of selected key proteins by immunoblotting.

Results
We show that common evaluation techniques of kidney biopsies were not predictive for posttransplantation outcomes. In contrast, despite the limited cohort size, the proteomic analysis was able to clearly differentiate between kidneys yielding extreme posttransplantation outcome differences. Pathway analysis of the proteomic data suggested that outcome-related variance in protein abundance associated with profibrotic, apoptosis, and antioxidant proteins. Immunoblotting confirmation further supported this observation.

Conclusions
We present preliminary data indicating that there is scope for existing evaluation approaches to be supplemented by the analysis of proteomic differences. Furthermore, the observed outcome-related variance in a limited cohort was supported by immunoblotting and is consistent with mechanisms previously implicated in the development of injury and cytoprotection in kidney transplantation.
International Liver Transplantation Consensus Statement on End-stage Liver Disease Due to Nonalcoholic Steatohepatitis and Liver Transplantation
Authors: Tsochatzis Emmanuel , Coilly Audrey , Nadalin Silvio , Levistky Josh , Tokat Yaman , Ghobrial Mark , Klinck John , Berenguer Marina 
Published: August 2018

Abstract
Nonalcoholic steatohepatitis (NASH)-related cirrhosis has become one of the most common indications for liver transplantation (LT), particularly in candidates older than 65 years. Typically, NASH candidates have concurrent obesity, metabolic, and cardiovascular risks, which directly impact patient evaluation and selection, waitlist morbidity and mortality, and eventually posttransplant outcomes. The purpose of these guidelines is to highlight specific features commonly observed in NASH candidates and strategies to optimize pretransplant evaluation and waitlist survival. More specifically, the working group addressed the following clinically relevant questions providing recommendations based on the Grading of Recommendation, Assessment, Development and Evaluation (GRADE) system supported by rigorous systematic reviews and consensus: (1) Is the outcome after LT similar to that of other etiologies of liver disease? (2) Is the natural history of NASH-related cirrhosis different from other etiologies of end-stage liver disease? (3) How should cardiovascular risk be assessed in the candidate for LT? Should the assessment differ from that done in other etiologies? (4) How should comorbidities (hypertension, diabetes, dyslipidemia, obesity, renal dysfunction, etc.) be treated in the candidate for LT? Should treatment and monitoring of these comorbidities differ from that applied in other etiologies? (5) What are the therapeutic strategies recommended to improve the cardiovascular and nutritional status of a NASH patient in the waiting list for LT? (6) Is there any circumstance where obesity should contraindicate LT? (7) What is the optimal time for bariatric surgery: before, during, or after LT? (8) How relevant is donor steatosis for LT in NASH patients?
Unusual Bilateral Renal Parenchymal Urine Leak After Pediatric En Bloc Kidney Transplantation: First Case Study Report
Authors: Sharma Amit , Nayak Rahul U. , Gupta Gaurav , Cotterell Adrian 
Published: August 2018

Abstract
Kidney transplantation is usually the best course of treatment for patients with end-stage renal disease. En bloc kidney transplantation (EBKT) is a surgical treatment option that increases available donor organs with excellent graft survival for patients with end-stage renal disease. Herein, we report a case of an unusual bilateral renal parenchymal urine leak after EBKT leading to removal of both moieties of the EBKT. This unfortunate complication after EBKT, to our knowledge, is the only reported of its kind. We explore the possible causes of the bilateral parenchymal urine leaks and suggest preventive strategies to avoid urological complications after EBKT.
Knowledge sharing in technology-intensive manufacturing organizations
Authors: AlShamsi Omran Mohamed , Ajmal Mian M. 
Published: August 2018

Purpose
This purpose of this paper is to identify and prioritize the critical factors impacting knowledge sharing (KS) in technology-intensive manufacturing organizations in the United Arab Emirates (UAE) and to propose a decision-making framework for KS.

Design/methodology/approach
Analytical Hierarchical Process method is used to identify these critical factors impacting KS in technology-intensive manufacturing organizations in the UAE.

Findings
Results show that organizational leadership and culture are the most critical factors impacting KS in the technology-intensive manufacturing organizations.

Research limitations/implications
The data are collected from technology-intensive manufacturing organizations in the UAE; therefore, these cannot be generalized to other locations. Future research in different countries is required.

Practical implications
To implement successful KS practices in technology-intensive manufacturing organizations, it is essential that all impacting factors and sub-factors are well understood within the organizations.

Originality/value
This study is among the first studies in the region that presents a comprehensive framework for KS in manufacturing sector.
Evaluation of Google question-answering quality
Authors: Zhao Yiming , Zhang Jin , Xia Xue , Le Taowen 
Published: August 2018

PurposeThe purpose of this paper is to evaluate Google question-answering (QA) quality.Design/methodology/approachGiven the large variety and complexity of Google answer boxes in search result pages, existing evaluation criteria for both search engines and QA systems seemed unsuitable. This study developed an evaluation criteria system for the evaluation of Google QA quality by coding and analyzing search results of questions from a representative question set. The study then evaluated Google’s overall QA quality as well as QA quality across four target types and across six question types, using the newly developed criteria system. ANOVA and Tukey tests were used to compare QA quality among different target types and question types.FindingsIt was found that Google provided significantly higher-quality answers to person-related questions than to thing-related, event-related and organization-related questions. Google also provided significantly higher-quality answers to where- questions than to who-, what- and how-questions. The more specific a question is, the higher the QA quality would be.Research limitations/implicationsSuggestions for both search engine users and designers are presented to help enhance user experience and QA quality.Originality/valueParticularly suitable for search engine QA quality analysis, the newly developed evaluation criteria system expanded and enriched assessment metrics of both search engines and QA systems.
Timely assessment of disaster and emergency response networks in the aftermath of superstorm Sandy, 2012
Authors: Yeo Jungwon , Comfort Louise , Jung Kyujin 
Published: August 2018

PurposeThe purpose of this paper is to elaborate pros and cons of two coding methods: the rapid network assessment (RNA) and the manual content analysis (MCA). In particular, it focuses on the applicability of a new rapid data extraction and utilization method, which can contribute to the timely coordination of disaster and emergency response operations.Design/methodology/approachUtilizing the data set of textual information on the Superstorm Sandy response in 2012, retrieved from the LexisNexis Academic news archive, the two coding methods, MCA and RNA, are subjected to social network analysis.FindingsThe analysis results indicate a significant level of similarity between the data collected using these two methods. The findings indicate that the RNA method could be effectively used to extract megabytes of electronic data, characterize the emerging disaster response network and suggest timely policy implications for managers and practitioners during actual emergency response operations and coordination processes.Originality/valueConsidering the growing needs for the timely assessment of real-time disaster response systems and the emerging doubts regarding the effectiveness of the RNA method, this study contributes to uncovering the potential of the RNA method to extract relevant data from the megabytes of digitally available information. Also this research illustrates the applicability of MCA for assessing real-time disaster response networks by comparing network analysis results from data sets built by both the RNA and the MCA.
Self-leadership strategies and career success: insight on sports organizations
Authors: Megheirkouni Majd 
Published: August 2018

PurposeThe purpose of this paper is to investigate the direct and indirect relationship between self-leadership strategies and career success, using self-efficacy as a mediator.Design/methodology/approachA quantitative methods approach was used to gather the data, using a sample of 418 registered individuals in sports organizations.FindingsThe results revealed that there is a significant relationship between self-leadership strategies and self-efficacy, and between self-efficacy and career success. Further, self-efficacy was found to fully mediate the relationship between the self-leadership and career success.Research limitations/implicationsThe paper provides an insight into the direct and indirect relationships between self-leadership and career success. In addition, this paper suggests future directions that researchers can undertake to advance self-leadership in the field of leadership research and the area of sport leadership.Originality/valueSelf-leadership has become an essential need today for most leadership roles in sport settings. The present study also advances self-leadership research in sport settings.