bluuebunny/crossref_metadata_2025_split huggingface dataset:
RETRACTED ARTICLE: The BET inhibitor I-BET762 inhibits pancreatic ductal adenocarcinoma cell proliferation and enhances the therapeutic effect of gemcitabine
Authors: Xie Fang , Huang Mei , Lin Xiansheng , Liu Chenhai , Liu Zhen , Meng Futao , Wang Chao , Huang Qiang 
Published: May 2018

AbstractAs one of the most fatal malignancies, pancreatic ductal adenocarcinoma (PDAC) has significant resistance to the currently available treatment approaches. Gemcitabine, the standard chemotherapeutic agent for locally advanced and metastatic PDAC, has limited efficacy, which is attributed to innate/acquired resistance and the activation of prosurvival pathways. Here, we investigated the in vitro efficacy of I-BET762, an inhibitor of the bromodomain and extraterminal (BET) family of proteins, in treating PDAC cell lines alone and in combination with gemcitabine (GEM). The effect of these two agents was also examined in xenograft PDAC tumors in mice. We found that I-BET762 induced cell cycle arrest in the G0/G1 phase and cell death and suppressed cell proliferation and metastatic stem cell factors in PDAC cells. In addition, the BH3-only protein Bim, which is related to chemotherapy resistance, was upregulated by I-BET762, which increased the cell death triggered by GEM in PDAC cells. Moreover, GEM and I-BET762 exerted a synergistic effect on cytotoxicity both in vitro and in vivo. Furthermore, Bim is necessary for I-BET762 activity and modulates the synergistic effect of GEM and I-BET762 in PDAC. In conclusion, we investigated the effect of I-BET762 on PDAC and suggest an innovative strategy for PDAC treatment.
Identification of amino acids with sensitive nanoporous MoS2: towards machine learning-based prediction
Authors: Barati Farimani Amir , Heiranian Mohammad , Aluru Narayana R. 
Published: May 2018

AbstractProtein detection plays a key role in determining the single point mutations which can cause a variety of diseases. Nanopore sequencing provides a label-free, single base, fast and long reading platform, which makes it amenable for personalized medicine. A challenge facing nanopore technology is the noise in ionic current. Here, we show that a nanoporous single-layer molybdenum disulfide (MoS2) can detect individual amino acids in a polypeptide chain (16 units) with a high accuracy and distinguishability. Using extensive molecular dynamics simulations (with a total aggregate simulation time of 66 µs) and machine learning techniques, we featurize and cluster the ionic current and residence time of the 20 amino acids and identify the fingerprints of the signals. Using logistic regression, nearest neighbor, and random forest classifiers, the sensor reading is predicted with an accuracy of 72.45, 94.55, and 99.6%, respectively. In addition, using advanced ML classification techniques, we are able to theoretically predict over 2.8 million hypothetical sensor readings’ amino acid types.
Loudness Perception of Pure Tones in Parkinson's Disease
Authors: Abur Defne , Lupiani Ashling A. , Hickox Ann E. , Shinn-Cunningham Barbara G. , Stepp Cara E. 
Published: May 2018

PurposeReduced intensity is a hallmark of speech production in Parkinson's disease (PD). Previous work has examined the perception of intensity in PD to explain these speech deficits. This study reports loudness ratings of pure tones by individuals with PD and controls, all with normal thesholds for older adults.MethodTwenty individuals with PD and 23 age- and sex-matched controls rated the loudness of pure tones from 1 (very soft) to 7 (uncomfortably loud). Tones at 500, 750, 1000, 2000, and 4000 Hz were presented from 35 to 80 dB HL (or until a rating of 7 was given). A mixed-model analysis of variance was performed on ratings to assess the effects of group, frequency, sound intensity, and ear. Loudness growth slopes were determined for each participant and analyzed by group.ResultsThe mean loudness growth slopes of the control and PD groups did not significantly differ.ConclusionsNo difference was found in loudness growth slopes in response to externally generated tones in PD. This is in contrast with the findings of previous studies of self-generated speech and externally presented speech. The underlying causes for impaired perception and production of loudness in PD require further investigation.
Periphere arterielle Verschlusskrankheit als Ursache für unilaterale Schmerzzustände im Gesäß- und Oberschenkelbereich
Authors: Lackenbauer Wolfgang 
Published: May 2018

ZusammenfassungDas gezielte und systematische Screening auf pathologische Prozesse oder schwere Verletzungen (Red-Flag-Screening), die sich nicht für physiotherapeutische
Maßnahmen eignen, ist ein fester Bestandteil offizieller Leitlinien der World Confederation for Physical Therapy (WCPT). Mangelnde diagnostische Validität
individueller Red Flags und die geringe Prävalenz einzelner schwerwiegender Pathologien (vorwiegend der LWS) stellen die Sinnhaftigkeit des Red-Flag-Screenings
als Teil der klinischen Untersuchung infrage. Demgegenüber steht eine Vielzahl publizierter Fallbeispiele, die demonstrieren, dass ein umfassendes
Screening-Verfahren einen wichtigen Beitrag zur Identifizierung verschiedenster Krankheitsprozesse leisten kann.Der vorliegende Fallbericht beschreibt eine Patientin, die mit der Diagnose Lumboischialgie zur Physiotherapie überwiesen wurde. Durch eine Kombination aus
gründlicher Anamnese, Erhebung verschiedener Risikofaktoren und nachfolgender physischer Untersuchung kamen beim behandelnden Physiotherapeuten Zweifel an einer
neuromuskuloskeletalen Ursache der Beschwerden auf. Die von ihm angeratene fachärztliche Untersuchung führte zur korrekten Diagnose periphere arterielle
Verschlusskrankheit.
Manuelle Therapie bei zystischer Fibrose – sinnvolle Ergänzung zur Atemtherapie
Authors: von Greyerz-Bokma Janneke 
Published: May 2018

ZusammenfassungPatienten mit zystischer Fibrose zeigen manchmal auch hypomobile Funktionsstörungen der Wirbelgelenke oder kostovertebralen Gelenke, die dann wiederum die
Belüftung der Lunge beeinflussen können. Neben Atemtherapie, Bindegewebsmassage, Massage und Übungen ist die Manuelle Therapie für die Physiotherapeutin Janneke
von Greyerz-Bokma ein gutes Werkzeug, um die Wirbelsäule und den Thorax beweglicher zu machen. Frau Lenz
1
aus dem
Fallbeispiel ist nach der manuellen Therapie nicht nur mobiler, sondern kann auch besser abhusten.
Effects of Different Resistance Training Frequencies on Fat in Overweight/Obese Older Women
Authors: Cavalcante Edilaine , Ribeiro Alex , do Nascimento Matheus , Silva Analiza , Tomeleri Crisieli , Nabuco Hellen , Pina Fábio , Mayhew Jerry , Da Silva-Grigoletto Marzo , da Silva Danilo , Fleck Steven , Cyrino Edilson 
Published: May 2018

Abstract
Aim This study compared the effect of different resistance training (RT) frequencies on total, android, gynoid and trunk body fat in overweight/obese older women.
Methods Fifty-seven overweight/obese older women (66.9±5.3 years and 39.9±4.9% body fat) were randomly assigned to one of three groups: a group performing RT twice a week (G2X), a group performing RT three times a week (G3X), or a non-exercise control group (CG). Both training groups performed the same 12-week RT program consisting of 8 exercises that trained all major muscle groups. Dual-energy X-ray absorptiometry was used to assess body composition.
Results After the intervention period, both G2X and G3X demonstrated significant (P<0.05) reductions in adiposity compared to the CG for total body fat (G2X=–1.7%, G3X=–2.7%, CG=+2.1%), android fat (G2X=–6.2%, G3X=–7.0%, CG=+8.6%), gynoid fat (G2X=–2.5%, G3X=–2.9%, CG=+1.0%), and trunk fat (G2X=–2.5%, G3X=–3.0%, CG=+2.9%), with no significant differences between training groups.
Conclusion These results demonstrate that a low-volume 12-week RT program performed two or three times per week causes decreases in total and regional fat deposition with the greatest reductions occurring in the android region.
Static Postural Stability in Chronic Ankle Instability, an Ankle Sprain and Healthy Ankles
Authors: Kwon Yong 
Published: May 2018

AbstractTo identify the single leg balance (SLB) test that discriminates among healthy, coper, and chronic ankle instability (CAI) groups and to determine effects of ankle muscles on the balance error scoring system (BESS) among the three populations. 60 subjects (20 per group) performed the SLB test with eyes open (EO) and eyes closed (EC). Normalized mean amplitude (NMA) of the tibia anterior (TA), fibularis longus (FL), and medial gastrocnemius (MG) muscles and BESS were measured while performing the SLB test. The coper group had a lower error score than the CAI group in the EC. NMA was greater in the CAI group compared to in the healthy and coper groups regardless of muscle type. NMA of the TA was less than the PL and MG regardless of the group in the EO. The CAI group demonstrated greater NMAs of the PL and MG than the healthy and coper groups in the EC. The CAI group demonstrated greater NMA of the PL and MG by compensating their ankle muscles in the EO and EC. BESS suggests that the coper group may have coping mechanisms to stabilize static postural control compared to the CAI group. The EC may be better to detect static postural instability in the CAI or coper group.
What is ‘regeneration’ and who needs it?
Authors: Thane Pat 
Published: May 2018

AbstractRegeneration is an ambiguous term with diverse meanings. According to the Oxford English Dictionary, to be regenerated is to be ‘re-born; brought again into existence; formed anew’, no doubt an accurate usage but one that is arguably too narrow. More appropriate is another meaning the OED suggests: ‘restored to a better state’. Most definitions of regeneration have been driven, over many times and places, by concern about ageing and the desire, at best, to reverse or, at least, to modify its perceived ill-effects. This article considers what we understand by regeneration and who needs it.
Final report on comparison of hydraulic pressure balance effective area determination in the range up to 80 MPa
Authors: Bermanec L Grgec , Pantic D , Ramac B 
Published: May 2018

Bilateral comparison was organized between the laboratory for process measurement of the Croatian Metrology Institute (HMI/FSB-LPM) and the pressure laboratory of the Directorate of Measures and Precious Metals of the Republic of Serbia (DMDM). Laboratory for process measurement of HMI acted as the pilot laboratory. The aim of the comparison was to evaluate the degree of equivalence in the determination of effective area and elastic distortion coefficient, considering respective uncertainties of the two laboratories. Measurements were done on the pressure balance in gauge mode, with oil as transmitting medium, in the gauge pressure range 10–80 MPa. The results of the comparison successfully demonstrated that the hydraulic gauge pressure standards are equivalent within their claimed uncertainties.

Main text

To reach the main text of this paper, click on Final Report. Note that this text is that which appears in Appendix B of the BIPM key comparison database kcdb.bipm.org/.
The final report has been peer-reviewed and approved for publication by the CCM, according to the provisions of the CIPM Mutual Recognition Arrangement (CIPM MRA).
Optimal resource diffusion for suppressing disease spreading in multiplex networks
Authors: Chen Xiaolong , Wang Wei , Cai Shimin , Stanley H Eugene , Braunstein Lidia A 
Published: May 2018

Abstract
Resource diffusion is a ubiquitous phenomenon, but how it impacts epidemic spreading has received little study. We propose a model that couples epidemic spreading and resource diffusion in multiplex networks. The spread of disease in a physical contact layer and the recovery of the infected nodes are both strongly dependent upon resources supplied by their counterparts in the social layer. The generation and diffusion of resources in the social layer are in turn strongly dependent upon the state of the nodes in the physical contact layer. Resources diffuse preferentially or randomly in this model. To quantify the degree of preferential diffusion, a bias parameter that controls the resource diffusion is proposed. We conduct extensive simulations and find that the preferential resource diffusion can change phase transition type of the fraction of infected nodes. When the degree of interlayer correlation is below a critical value, increasing the bias parameter changes the phase transition from double continuous to single continuous. When the degree of interlayer correlation is above a critical value, the phase transition changes from multiple continuous to first discontinuous and then to hybrid. We find hysteresis loops in the phase transition. We also find that there is an optimal resource strategy at each fixed degree of interlayer correlation under which the threshold reaches a maximum and the disease can be maximally suppressed. In addition, the optimal controlling parameter increases as the degree of inter-layer correlation increases.
Primary Care Physicians’ Perceived Barriers to Optimal Dementia Care: A Systematic Review
Authors: Mansfield Elise , Noble Natasha , Sanson-Fisher Rob , Mazza Danielle , Bryant Jamie 
Published: May 2018

Abstract

Background and Objectives
Primary care physicians (PCPs) have a key role in providing care for people with dementia and their carers, however, a range of barriers prevent them from delivering optimal care. We reviewed studies on PCPs’ perceptions of barriers to providing optimal dementia care, including their methodological quality, whether they focused on barriers related to diagnosis and/or management, and the patient-, provider-, and system-level barriers identified.

Research Design and Methods
Studies were included if they were quantitative studies published since 2006 which reported on PCPs’ perceptions of the barriers to providing dementia care. The methodological quality of identified studies was assessed using an adapted version of accepted rating criteria for quantitative studies. Data were extracted from studies which were rated as “moderate” or “strong” quality.

Results
A total of 20 studies were identified, 16 of which were rated as “moderate” or “strong” methodological quality. Patient-related barriers included a reluctance to acknowledge cognitive decline and patient nonadherence to management plans. Provider-related barriers included a lack of training and confidence. System-related barriers included a lack of time during consultations and lack of support services.

Discussion and Implications
This review highlights a range of barriers to dementia diagnosis and management from studies rated as being methodologically adequate. Future studies should also utilize theory-driven approaches to exploring a comprehensive range of barriers to optimal dementia care across the care trajectory.
Microsurgical Resection of Ruptured Large Left Temporo-Occipital Arteriovenous Malformation: 3-Dimensional Operative Video
Authors: Cheng Chun-Yu , Shetty Rakshith , Sekhar Laligam N 
Published: May 2018

Abstract
A 59-yr-old man presented with intraventricular hemorrhage and was found to have a large temporo-occipital arteriovenous malformation (AVM), Spetzler–Martin grade 4. The preoperative intra-arterial digital subtraction angiography (IADSA) showed the AVM was 4 × 4 cm2, had superficial and deep venous drainage, and was fed by multiple branches of the posterior cerebral artery and middle cerebral artery. Preoperative embolization was done in 4 stages.
He underwent a left temporo-occipital craniotomy, mastoidectomy, and retrosigmoid craniotomy with a posterior temporal approach. Intraoperatively, there was a large draining vein draining into the sigmoid sinus in the location of the vein of Labbe, and multiple other feeding arteries and draining veins, including periventricular vessels. Circumferential dissection of the AVM was done from posteriorly, superiorly, anteriorly, and then inferiorly. The technique of temporary clipping and cauterizing the perforating arteries, and then sectioning them after flow arrest is shown in the video. Large arterial feeders were cauterized and divided. Three permanent aneurysm clips were left to control bleeding from the vessels of the trigone of the lateral ventricle. After the large draining vein into the sigmoid sinus was occluded, the AVM was completely removed. The patient had acute nonfluent aphasia postoperatively but improved after speech therapy. The postoperative IADSA demonstrated total resection. At 3-mo follow-up, he had recovered completely (mRS0).
This 3-D video shows the technical nuances of microsurgical resection of a complex large AVM.
Informed consent was obtained from the patient prior to the surgery that included videotaping of the procedure and its distribution for educational purposes. All relevant patient identifiers have also been removed from the video and accompanying radiology slides.
General Principles for Pial Synangiosis in Pediatric Moyamoya Patients: 2-Dimensional Operative Video
Authors: Penn David L , Wu Kyle C , Presswood Kayla R , Riordan Coleman P , Scott R Michael , Smith Edward R 
Published: May 2018

Abstract
Pial synangiosis is a method of indirect surgical revascularization developed at our institution for the treatment of moyamoya disease in pediatric patients. Similar surgical principles are employed in adult cases, often performed because of lack of an adequate donor vessel. Standardized protocols, including preadmission for preoperative intravenous hydration and aspirin administration, as well as intraoperative electroencephalography, are routinely employed to minimize operative risk. Perioperative heparinization is not required. The patient is positioned supine, without skull fixation, and the parietal branch of the superficial temporal artery is mapped with Doppler ultrasonography. The artery is microscopically dissected from distal to proximal, leaving a cuff of tissue around the vessel and elevated from the temporalis. The microscope is then removed, the temporalis is opened in a cruciate fashion, and a generous craniotomy is performed, with care to drill away from the exposed artery. The dura is then opened widely (preserving dural collateral vessels), followed by microscopic opening of the arachnoid in as many areas as possible. The donor vessel is then sutured to the pia with 10-0 nylons. The dural leaflets are laid on the brain (without suturing). Closure is completed with saline-soaked gelfoam, with fixation of the bone flap, and muscle reapproximation in the horizontal plane. The galea is closed, followed by the use of resorbable skin suture in pediatric patients. If indicated, the second hemisphere may be performed under the same anesthetic, reducing anesthetic risks and avoiding delayed revascularization. Postoperatively, the patient is awakened and transferred to the intensive care unit.
BARRIERS TO IMPLEMENTATION OF EARLY PEANUT INTRODUCTION AMONG PEDIATRICIANS, FAMILY PHYSICIANS, AND ALLERGISTS
Authors: Singer Alexander , Abrams Elissa , Soller Lianne , Chan Edmond 
Published: May 2018

Abstract

BACKGROUND
The approach to peanut allergy prevention has shifted with publication of the Learning Early About Peanut (LEAP) trial and recently released NIAID guideline recommending early peanut introduction in high risk infants.

OBJECTIVES
Our objective was to determine whether current practice patterns at both the allergist and primary care level are in keeping with the LEAP recommendations and NIAID guideline.

DESIGN/METHODS
A 17-question survey was distributed in 2016 to Canadian allergists through the Canadian Society of Allergy and Clinical Immunology, paediatricians through the Canadian Paediatric Society, and a sample of practicing family physicians.

RESULTS
There was variability in the definition of infants at high risk for peanut allergy and recommendations for age of introduction of allergenic solids. There was also variability in how often allergist evaluation was recommended for infants with egg allergy or severe eczema prior to peanut introduction, with allergists 9 times more likely to recommend pre-emptive peanut testing in infants with severe eczema prior to peanut introduction. The majority of family physicians (77.1%), paediatricians (91.4%) and allergists (89.1%) did not believe there was harm to introduction of solids between 4–6 months of age, or that breastfeeding rates would be affected with earlier solid introduction.

CONCLUSION
Further education about the implications of LEAP is required. There are broad issues (such as the definition of a high risk infant) that require international consensus. Most primary care physicians and allergists do not believe there are harms to introduction of allergenic solids prior to 6 months of age, or that breastfeeding rates will be affected.
EMERGENCY DEPARTMENT VISITS BY CHILD REFUGEE CLAIMANTS AT A PEDIATRIC TERTIARY CARE CENTER
Authors: Evans Andrea , Ratnapalan Savithiri 
Published: May 2018

Abstract

BACKGROUND
The Canadian government has announced the resettlement of 50 000 refugees from the Middle East by 2018. The proportion of refugees that are below 18 years of age have increased from 20% to almost 40% from 2005 to 2014 and is expected to increase further with new refugee influxes. Barriers to timely health care can worsen clinical presentations and outcomes, especially in vulnerable children such as refugees. This study aims to provide an overview of the epidemiology, clinical presentations, hospital stay metrics, and non-clinical support needs for child refugee claimants presenting to the emergency department at a large tertiary care hospital in Canada.

OBJECTIVES
To describe the emergency department visits by refugee claimants with IFH, including demographics, primary care access, immunization status, acuity of presentation, repeat visits, and admission rates.

DESIGN/METHODS
A retrospective chart review of all refugee children presenting to the emergency department at this tertiary care hospital from April 1 2014 to March 31st 2017. A case was defined as a child who presented to the hospital with Interim Federal Health (IFH) which is the federal health insurance program covers newly arrived refugee claimants in Canada. Descriptive statistics and chi square test for categorical data was used. Data was analyzed using SPSS v21 IBM 2012. Ethics was approved by the Ethics Review Board of the hospital.

RESULTS
In total, there were 646 visits to the emergency department by 388 patients with IFH. The average age was 6.4 years (IQR 2.9–9.3), of which 58% were females. Travel history was documented in 65% of cases. The majority of patients arrived from Southeast Asia and the Middle East. The average time spent in Canada was 217 days (IQR 78–205). Sixty percent of patients did not have an identified primary care provider. Those with an identified primary care provider had more non-acute (CTAS 4–5) visits than those without an identified primary care provider (p<0.05). Immunizations were not up-to-date per Canadian standard in 25% of those who had an immunization history documented. Translation services was used in 11% of visits. Admission rate was 12%, with average length of stay 3.4 days (std 4). Top three reasons for admission were febrile neutropenia, respiratory distress, and blood per rectum. One fifth (20%) of admissions occurred on the same day as the arrival of the patient to Canada.

CONCLUSION
A significant number of refugee children are needing emergency care and admission to hospital on the day they arrive to Canada. Most child refugees presenting to the emergency department did not have an identified primary care provider, and a quarter did not have up-to-date immunizations. Association with primary care provider suggests that linkage to primary care in this population should be a priority.