bluuebunny/crossref_metadata_2025_split huggingface dataset:
Detection of testosterone doping in female athletes
Authors: Handelsman David J. , Bermon Stéphane 
Published: August 2019

AbstractTestosterone doping remains a prevalent and potent form of drug cheating among elite athletes. In men, the urine testosterone (T) to epitestosterone (E) ratio (T/E ratio) can identify administration of exogenous T by its suppression of endogenous T production through strong negative feedback on endogenous T and E production as well as spill over into urine of extra testosterone. However, this mechanism may be partially inoperative in females whose much lower circulating T derives from three sources, none subject to powerful negative T feedback. Hence, additional methods to detect T doping in females are required. In this study we report two cases of elite female athletes who were sanctioned for T doping proven by measurement of serum T using liquid chromatography−mass spectrometry (LC–MS), when serial urine T and T/E ratio in one were not indicative of T doping, and in the other were nullified by incidental genetic inactivation of T glucuronidation through the uridine diphosphoglucuronosyl transferase 2B17 (UGT2B17) deletion genotype–phenotype. These findings indicate the potential for serum T measurement by LC–MS to detect T doping in female athletes, especially if implemented in the Bayesian format of an athlete biological passport.
Human embryonic ribs all progress through common morphological forms irrespective of their position on the axis
Authors: Matsubayashi Jun , Okuno Kasumi , Fujii Sena , Ishizu Koichi , Yamada Shigehito , Yoneyama Akio , Takakuwa Tetsuya 
Published: August 2019

AbstractBackgroundWe aimed to analyze the morphogenesis of all ribs from 1st to 12th rib pairs plus vertebrae to compare their differences and features according to the position along the cranial‐caudal axis during the human embryonic period.ResultsRib pair formation was analyzed using high‐resolution digitalized imaging data (n = 29) between Carnegie stage (CS) 18 and CS23 (corresponding to ED13‐14 in mouse; HH29‐35 in chick). A total of 348 rib pairs, from 1st to 12th rib pairs of each sample were subjected to Procrustes and principal component (PC) analyses. PC1 and PC2 accounted for 76.3% and 16.4% (total 92.7%) of the total variance, respectively, indicating that two components mainly accounted for the change in shape. The distribution of PC1 and PC2 values for each rib showed a “fishhook‐like shape” upon fitting to a quartic equation. PC1 and PC2 value position for each rib pair moved along the fitted curve according to the development. Thus, the change in PC1 and PC2 could be expressed by a single parameter using a fitted curve as a linear scale for shape.ConclusionHuman embryonic ribs all progress through common morphological forms irrespective of their position on the axis.
The various and shared roles of lncRNAs during development
Authors: Murillo‐Maldonado Juan M. , Riesgo‐Escovar Juan R. 
Published: August 2019

AbstractlncRNAs, genes transcribed but not translated, longer than 200 nucleotides, are classified as a separate class of nonprotein coding genes. Since their discovery, largely from RNAseq data, a number of pioneer studies have begun to unravel its myriad functions, centered on gene expression regulation, suggesting developmental and evolutionary conservation. Since they do not code for proteins and have no open reading frames, their functional constraints likely differ from that of protein coding genes, or of genes where the majority of the nucleotide sequence is required for function, like tRNAs. This has complicated assessment of both developmental and evolutionary conservation, and the identification of homologs in different species. Here we argue that other characteristics: general synteny and particular chromosomal placement regardless of sequence, sequence micro‐motifs, and secondary structure allow for “homologs” to be identified and compared, confirming developmental and evolutionary conservation of lncRNAs. We conclude exemplifying a case in point: that of the evolutionarily conserved lncRNA acal, characterized and required for embryogenesis in Drosophila.
Plants trap pollen to feed predatory arthropods as an indirect resistance against herbivory
Authors: Van Wyk Jennifer I. , Krimmel Billy A. , Crova Laure , Pearse Ian S. 
Published: August 2019

AbstractPlants commonly employ indirect resistance to reduce herbivory by provisioning predatory arthropod populations with additional resources. Numerous predatory arthropods consume pollen that is entrapped on dense, wooly trichomes of plants. Over two seasons, we supplemented pollen on the wooly leaves of turkey mullein, Croton setiger, in natural populations to determine if pollen entrapped on leaves supplements predatory arthropods and reduces herbivore populations and damage to the plant. Pollen supplementation increased the abundance of predatory spiders in both years and omnivorous Orius bugs in 1 yr but had no effect on predatory hemipterans. Pollen supplementation reduced the abundance of herbivorous fleahoppers. Pollen supplementation decreased the amount of leaf damage experienced by plants over the season, suggesting that pollen entrapment may act as an indirect resistance. While C. setiger plants have little control over the amount of pollen on their surfaces, pollen adds to the diet of predatory arthropods that reduce herbivory, thus attraction of predators may be an adaptive benefit of leaf structures such as wooly trichomes that entrap pollen.
Temporal changes in species composition affect a ubiquitous species’ use of habitat patches
Authors: Bledsoe Ellen K. , Ernest S. K. Morgan 
Published: August 2019

AbstractAcross landscapes, shifts in species composition often co‐occur with shifts in structural or abiotic habitat features, making it difficult to disentangle the role of competitors and environment on assessments of patch quality. Using over two decades of rodent community data from a long‐term experiment, we show that a small, ubiquitous granivore (Chaetodipus penicillatus) shifted its use of different experimental treatments with the establishment of a novel competitor,C. baileyi. Shifts in residency, probability of movement between patches, and the arrival of new individuals in patches altered which treatment supported the highest abundances ofC. penicillatus. Our results suggest that the establishment of a new species worsened the quality of the originally preferred treatment, likely by impacting resource availability. Paradoxically, the presence of the new species also increasedC. penicillatus’use of the less preferred treatment, potentially through shifts in the competitive network on those plots.
New insight to the characteristics and clinical course of clusters of patients with imaging confirmed disc‐related sciatica
Authors: Stynes Siobhán , Grøvle Lars , Haugen Anne Julsrud , Konstantinou Kika , Grotle Margreth 
Published: August 2019

AbstractBackgroundReferral to secondary care is common for a considerable proportion of patients with persistent sciatica symptoms. It is unclear if information from clinical assessment can further identify distinct subgroups of disc‐related sciatica, with perhaps different clinical courses.AimsThis study aims to identify and describe clusters of imaging confirmed disc‐related sciatica patients using latent class analysis, and compare their clinical course.MethodsThe study population were 466 patients with disc‐related sciatica. Variables from clinical assessment were included in the analysis. Characteristics of the identified clusters were described and their clinical course over 2 years was compared.ResultsA four‐cluster solution was optimal. Cluster 1 (n = 110) had mild back and leg pain; cluster 2 (n = 59) had moderate back and leg pain; cluster 3 (n = 158) had mild back pain and severe leg pain; cluster 4 (n = 139) had severe back and leg pain. Patients in cluster 4 had the most severe profile in terms of disability, distress and comorbidity and the lowest reported global change and the smallest proportion of patients with a successful outcome at 2 years. Of the 135 patients who underwent surgery, 42% and 41% were in clusters 3 and 4, respectively.ConclusionsUsing a strict diagnosis of sciatica, this work identified four clusters of patients primarily differentiated by back and leg pain severity. Patients with severe back and leg pain had the most severe profile at baseline and follow‐up irrespective of intervention. This simple classification system may be useful when considering prognosis and management with sciatica patients.SignificanceUsing data from a large observational prospective study, this work identifies four distinct clusters of patients with imaging confirmed disc‐related sciatica. This classification could be used when considering prognosis and management with sciatica patients at their initial consultation.
MR‐based age‐related effects on the striatum, globus pallidus, and thalamus in healthy individuals across the adult lifespan
Authors: Tullo Stephanie , Patel Raihaan , Devenyi Gabriel A. , Salaciak Alyssa , Bedford Saashi A. , Farzin Sarah , Wlodarski Nancy , Tardif Christine L. ,   the PREVENT‐AD Research Group, Breitner John C. S. , Chakravarty M. Mallar 
Published: August 2019

AbstractWhile numerous studies have used magnetic resonance imaging (MRI) to elucidate normative age‐related trajectories in subcortical structures across the human lifespan, there exists substantial heterogeneity among different studies. Here, we investigated the normative relationships between age and morphology (i.e., volume and shape), and microstructure (using the T1‐weighted/T2‐weighted [T1w/T2w] signal ratio as a putative index of myelin and microstructure) of the striatum, globus pallidus, and thalamus across the adult lifespan using a dataset carefully quality controlled, yielding a final sample of 178 for the morphological analyses, and 162 for the T1w/T2w analyses from an initial dataset of 253 healthy subjects, aged 18–83. In accordance with previous cross‐sectional studies of adults, we observed age‐related volume decrease that followed a quadratic relationship between age and bilateral striatal and thalamic volumes, and a linear relationship in the globus pallidus. Our shape indices consistently demonstrated age‐related posterior and medial areal contraction bilaterally across all three structures. Beyond morphology, we observed a quadratic inverted U‐shaped relationship between T1w/T2w signal ratio and age, with a peak value occurring in middle age (at around 50 years old). After permutation testing, the Akaike information criterion determined age relationships remained significant for the bilateral globus pallidus and thalamus, for both the volumetric and T1w/T2w analyses. Our findings serve to strengthen and expand upon previous volumetric analyses by providing a normative baseline of morphology and microstructure of these structures to which future studies investigating patients with various disorders can be compared.
Human resource management and industrial relations in multinational corporations in and from China: Challenges and new insights
Authors: Cooke Fang Lee , Liu Mingwei , Liu Leigh Anne , Chen Chao C. 
Published: August 2019

AbstractThe purpose of this article is to provide an overview on the state of research in the field in human resource management (HRM) issues in multinational corporations (MNCs) in and from China. We integrate previous studies from multiple disciplines to articulate the contextual importance of research on this topic, and suggest overarching themes to expand the field of research. HRM research in the intercultural, interinstitutional context of MNCs in and from China has the potential to provide contextualized insights for longstanding debates in the field such as HRM standardization versus localization and convergence versus divergence and contextual factors behind these patterns. To this end, we call for future research to center on the changing cultural, institutional, technological, and globalization context in understanding HRM and industrial relations issues in these MNCs. Practically, knowledge in this area can help global managers and top management teams in multinational organizations navigate various context complexity, foster more productive coordination and cooperation across borders, and gain legitimacy and MNCs in and from China additional competitive edge in the global marketplace.
Competency modeling: A theoretical and empirical examination of the strategy dissemination process
Authors: Campion Michael C. , Schepker Donald J. , Campion Michael A. , Sanchez Juan I. 
Published: August 2019

AbstractOne of the most important functions of a competency model is to translate organizational strategy into employee behavior. Yet, virtually no theoretical attempts to elucidate this process exist, and no empirical evidence has been offered demonstrating that it occurs. Drawing on the strategic management literature, we develop a conceptual framework delineating this process. We theorize that structurally distributed knowledge, attention, and behavior results in coalitions of individuals at different hierarchical levels (top managers vs employees) developing different dominant logics. These differences across levels in habituated modes of processing information and conceptualizing roles impact the initial importance assigned to competencies that are added to the model as an organization's strategy evolves. However, over time, competency models enable top managers to drive their dominant logic downward through the organization. As the importance of certain competencies is reinforced through performance management, schemata of high‐performers shift, becoming better aligned with those of top managers'. Using data from focus groups, surveys, and archives collected at two points in time (6 years apart) capturing change in the strategy of an organization of professional jobs in the U.S. government (n= 218), results were supportive. We then use our model to generate an agenda of research questions and topics to enhance competency modeling scholarship.
Finite element analysis of couple stress micropolar nanofluid flow by non‐Fourier's law heat flux model past stretching surface
Authors: Ibrahim Wubshet , Gadisa Gosa 
Published: August 2019

AbstractNumerical analysis has been done to investigate magnetohydrodynamics nonlinear convective flow of couple stress micropolar nanofluid with Catteneo‐Christov heat flux model past stretching surface with the effects of heat generation/absorption term, chemical reaction rate, first‐order slip, and convective boundary conditions. The coupled highly nonlinear differential equation governing the steady incompressible laminar flow has been solved by a powerful numerical technique called finite element method. The impacts of diverse parameters on linear velocity, angular velocity (microrotation), temperature, concentration profile, local skin friction coefficient, local wall couple stress, local Nusselt number, and Sherwood number are presented in graphical and tabular form. The result pointed out that the enhancement in material parameter β increases the velocity of the fluid while the couple stress parameter K has quite opposite effect. Heat and mass transfer rate of the fluid are enhanced by increasing material parameter while couple stress parameter shows the opposite influence. Moreover, heat and mass transfer rate are higher with the Catteneo‐Christov heat flux model than Fourier's law of heat conduction. The accuracy of the present method has been confirmed by comparing with previously published works.
Adaptation and implementation of the German social–emotional learning programme Papilio in Finland: A pilot study
Authors: Koivula Merja , Laakso Marja‐Leena , Viitala Riitta , Neitola Marita , Hess Markus , Scheithauer Herbert 
Published: August 2019

This study investigated the cross‐national adaptation and implementation of Papilio, a German social–emotional learning programme, in Finnish early childhood education and care (ECEC) centres. Papilio is a developmentally focused, scientifically based intervention programme focused on preventing behavioural problems and fostering social–emotional competence in children aged 3–7. The aim of this study was to investigate and evaluate the cross‐national adaptation and cross‐cultural adaptation and implementation of Papilio in the Finnish ECEC context. Results from qualitative interviews with one Finnish Papilio trainer, 11 early childhood education (ECE) teachers, two ECE special education teachers and two nursery nurses are supplemented with teachers' and nursery nurses' (N = 75) questionnaire data. Qualitative thematic analysis revealed that cultural adaptations were necessary on four levels: accommodation of materials, adaptation of the contents of the materials, structure and delivery. The materials and training contents were culturally adapted, whereas the delivery of the intervention was adapted according to Finnish ECEC practices. The structural adaptation included discarding timeout, due to opposition by some educators. The educators were committed to implementing the programme as instructed and resolving the practical difficulties they encountered. Their motivation to implement Papilio increased as they observed improvements in the children's social–emotional competence during intervention.
Different risk factors are associated with alcohol use versus problematic use in male Pakistani adolescents
Authors: Shahzad Salman , Kliewer Wendy , Ali Muzaffar , Begum Nasreen 
Published: August 2019

Substance abuse is a significant problem in Pakistan (Hussain, 2017), yet, there are few studies of risk factors in this population, particularly in remote areas. Male adolescents (N = 243; M = 16.9 years, SD = 1.3 years) were recruited from schools in Gilgit‐Baltistan, and completed questions on demographics, substance use, and psychosocial functioning. As a Muslim country, there are strict prohibitions against alcohol use, yet 44.9% of the sample reported lifetime alcohol use. The Alcohol Use Disorders Identification Test (Babor, Higgins‐Biddle, Saunders, & Monteiro, 2001), was used to quantify level of risk associated with use, and 22.6% of the sample had scores indicating significant risk levels. Logistic regression analyses indicated that lifetime alcohol use was associated with internalising problems (e.g., depression, anxiety), while risky alcohol use was associated with externalising problems (e.g., aggressive and delinquent behaviour). Attention problems were related to both outcomes. Implications for prevention are discussed.
Different expression profile of mRNA and long noncoding RNA in autoimmune thyroid diseases patients
Authors: Yi Ruhai , Yang Liyong , Zeng Saifan , Su Yueqing 
Published: August 2019

AbstractIncreasing evidence has found that long noncoding RNAs (lncRNAs) and message RNAs (mRNAs) play an important role in the progress of autoimmune thyroid diseases (AITD). So, in this study, the different expressed of lncRNA and mRNA was screened by microarray analysis and quantitative real‐time polymerase chain reaction (PCR). To further investigate the relationship among the differentially expressed genes, the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis and Gene ontology (GO) were used for biofunctions and signaling pathways analysis, respectively. Finally, the interaction relationship between lncRNA and mRNAs was analysis with lncRNA‐mRNA coexpression network. The result found that the abnormal expression of lncRNAs and mRNAs were 1615 and 1913, respectively. The altered genes included CD40LG, IFNG, CTLA4, FAS, STAT1, STAT3, and STAT4. These were enriched in presentation and antigen processing, Th1 and Th2 cell differentiation, natural killer cell‐mediated cytotoxicity, B cell receptor signaling pathway, Th17 cell differentiation, and cell adhesion molecules (CAMs), all of which had been suggested to be associated with immunopathogenic mechanisms and AITD‐induced pathophysiologic changes. A coexpression network profile was contained with 126 network nodes and 477 connections which were based on seven mRNAs and 119 interacted lncRNAs. The outcomes of differentially expressed lncRNAs and their coreralated mRNAs in our study revealed that lncRNAs involved in immunopathogenic mechanisms may play a crital role in the pathogenesis of AITD.
RETRACTED: miR‐125a suppresses malignancy of multiple myeloma by reducing the deubiquitinase USP5
Authors: Wu Liting , Zhang Cui , Chu Min , Fan Yingchao , Wei Lu , Li Zhumeng , Yao Yonghua , Zhuang Wenfang 
Published: August 2019

AbstractmiR‐125a is a microRNA that is frequently diminished in various human malignancies. However, the mechanism by which impaired miR‐125a promotes cancer growth remains undefined. In this study, we investigated the role of miR‐125a in the proliferation and apoptosis of multiple myeloma (MM). To do this, we used MM tissue samples (from 40 anonymous patients), normal matched control samples, and five MM‐derived cell lines. We also established a mouse model of MM xenograft to explore the effect of overexpression of miR‐125a on the MM growth in vivo. Quantitative real‐time polymerase chain reaction revealed that the miR‐125a expression was broadly reduced in MM tissues and cell lines. The impairment of miR‐125a in MM tissues was functionally relevant because the overexpression of miR‐125a remarkably decreased the cell viability and colony‐forming activity, at least in part, by promoting apoptosis in two miR‐125a‐deficient MM cell lines: NCI‐H929 and U266. Interestingly, we also discovered that the human gene encoding the ubiquitin‐specific peptidase 5 (USP5), which is known to promote cellular deubiquitination and ubiquitin/proteasome‐dependent proteolysis, was a direct transcriptional target for miR‐125a to repress. More importantly, the heterologous expression of USP5 significantly reversed the growth‐inhibitory effects of miR‐125a on MM cells in vitro. In the mouse xenograft model, overexpressed miR‐125a prominently inhibited the growth of MM tumors and concomitantly reduced the expression of USP5 in tumor tissues. These results suggest that miR‐125a inhibits the expression of USP5, thereby mitigating the proliferation and survival of malignant MM cells. We propose that USP5 acts as an oncoprotein in miR‐125a‐missing cancers.