bluuebunny/crossref_metadata_2025_split huggingface dataset:
Early COVID‐19 Vaccine Initiation and Completion Among Cancer Survivors and Barriers to Vaccine Completion: Implications for Future COVID‐19 Vaccination Uptake Rates
Authors: Saeedi Nikta , Arizpe Angel , Queen Katelyn J. , Tsui Jennifer , Kim Sue , Huang Brian Z. , Farias Albert J. 
Published: November 2024

ABSTRACTPurposeCancer survivors are considered by public health officials as a high‐risk group in the United States for severe complications from COVID‐19. We aimed to characterize patterns of early uptake of the COVID‐19 vaccine among cancer survivors and to determine modifiable barriers to vaccine completion that can be addressed to ensure future booster adherence.MethodsCross‐sectional data of vaccine uptake by summer 2021 was extracted from adult cancer survivors enrolled in the “All of Us” research program. Vaccine completion was determined based on receiving at least two doses. We assessed sociodemographic factors, socioeconomic barriers (education, income, health insurance status, housing, and employment status), and COVID‐19 vaccine uptake by Summer 2021, employing multivariable ordinal logistic regression for those who were unvaccinated, had initiated vaccine uptake, and had completed COVID‐19 vaccination.ResultsOf the 514 cancer survivors in the sample, 73.7% were fully vaccinated by summer 2021. Those who received no vaccine doses showed higher proportions of SES barriers, medical distrust, and perceived lack of need barriers. Race (non‐Hispanic White vs. other) was not statistically significantly associated with vaccine uptake (OR (95% CI) = 0.94 (0.51, 1.70)), while for every additional SES barrier, there was a 40% decrease (OR (95% CI) = 0.60 (0.48, 0.75)) in the odds of receiving more COVID‐19 vaccine doses. Higher medical distrust and perceived lack of need were associated with 56% (OR = 0.44, 95% CI: 0.32–0.59) and 39% (OR = 0.61, 95% CI: 0.43–0.87) lower odds, respectively.ConclusionRacial/ethnic disparities in vaccine uptake may be explained by SES barriers. Addressing SES disparities and fostering medical trust may enhance future COVID‐19 vaccination uptake rates for this high‐risk group.
Pharmacological Evaluation of Bakuchiol From Psoralea corylifolia L. as Potent Antimicrobial Agent Against Staphylococcus aureus
Authors: Tripathi Nancy , Roy Arnab , Agnivesh Puja Kumari , Bhardwaj Nivedita , Kumari Sanju , Kalia Nitin Pal , Jain Shreyans K. 
Published: November 2024

ABSTRACTThe surge in multidrug resistance in Staphylococcus aureus is the pressing need to identify novel alternatives to combat antimicrobial resistance effectively. Bakuchiol is a bioactive prenylated phenolic meroterpene largely abundant in the seeds of Psoralea corylifolia. In this study, we present the biological assessment of bakuchiol derived from P. corylifolia as an antimicrobial agent. S. aureus, a significant opportunistic pathogen, attracts global concern for its biofilm formation and resilience against numerous antibiotics, escaping antibiotic pressure. The primary screening of bakuchiol as an antimicrobial agent against S. aureus delineated its potential as a strong bactericidal agent with a minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of 2 and 8 µg/mL, respectively. Importantly, bakuchiol also exhibited low toxicity against HepG2 cells, showing a favorable selectivity index (SI) of 14.4. Furthermore, bakuchiol demonstrated comparable activity (MIC = 2 µg/mL) against a laboratory‐generated ciprofloxacin‐resistant mutant of S. aureus. Bakuchiol could significantly inhibit the biofilm formation of S. aureus in a dose‐dependent manner with minimum biofilm inhibitory concentration (MBIC)50 of 0.956 µg/mL. Bakuchiol effectively inhibited DNA gyrase supercoiling activity at a concentration eight times the MIC, establishing DNA gyrase inhibition as the mechanism of action for bakuchiol. Our findings suggest bakuchiol as a potential therapeutic agent for S. aureus‐mediated nosocomial infections.
Temperature‐Based Extraction, Characterization by Gas Chromatography–Mass Spectrometry and Fourier Transform Infrared Spectroscopy With Prospective Antibacterial Properties of Eri (Philosamia ricini) Pupal Oil
Authors: Mishra Akash , Verma Abhishek , Srivastava Devika , Kumar Ramappa Venkatesh 
Published: November 2024

ABSTRACTLepidopteran insects are novel source of omega‐3 fatty acids as revealed by the studies recently. In the current study, we assessed the effects of four different drying temperatures (50, 60, 70 and 80°C) of eri silkworm (Philosamia ricini) pupal oil (EPO) abbreviated as EPO50, 60, 70 and 80 followed by conducting the characterization and antibacterial efficacy studies. Gas chromatography–mass spectroscopy (GC–MS) and Fourier transform infrared (FTIR) were used for chemical profiling of EPOs. The agar‐well diffusion method was performed to evaluate the antibacterial activities. The trend of this study clearly revealed that enhanced drying percentage of temperatures showed raising saturated fats and reduced unsaturated fats. However, the best suitable temperature was found at 60°C with high unsaturated fatty acids, including omega‐3. Further, at higher temperature, FTIR analysis revealed an increasing complexity of functional groups with potential bioactive compounds. EPOs were found to have significant antibacterial activity against Salmonella typhi and Staphylococcus aureus at all tested (10, 20, 30 and 40 µL) volumes used in the study.
Creating Caring Campuses: A Faculty‐Led Approach
Authors: Barnett Elisabeth A. , Cho Selena , Cornelius Kristin M. , Phillips Brad C. 
Published: November 2024

ABSTRACTCaring Campus–Faculty is a program that supports faculty as they develop and implement “behavioral commitments” designed to help students feel a sense of belonging and to support them in their educational journey. Developed by the Institute for Evidence‐Based Change, Caring Campus was evaluated by the Community College Research Center (CCRC) from 2019 to 2023. In this article, we describe Caring Campus as practiced by faculty, as well as findings from the research on implementation practices and outcomes. We also share the experiences of Delta College, which has been implementing its own version of Caring Campus for a number of years. Caring Campus allows faculty to take leadership in student success efforts by changing instructional practices in ways that can improve student experiences and outcomes. Further, as they implement Caring Campus strategies, faculty encourage changes in the culture of the college in ways that support students as well as their own engagement with their work and each other.
The Tip of the Iceberg, But What's Underneath?: Hidden Shared Governance in the Community College
Authors: Kater Susan T. , Miller Michael T. 
Published: November 2024

ABSTRACTThis article proposes a new way of thinking about shared governance, focusing on the informal and sometimes unintentional interactions among faculty, staff, and even students. We argue that an operational place to start reconceptualizing shared governance is to look at the everyday interactions that collectively make up the hidden experiences of shared governance, or what we also refer to as the “base” rather than the “tip” of an iceberg. As such, shared governance can be viewed as a socially constructed concept that requires new and different thinking about how decisions are made and how a college's culture makes, and accepts decisions. We conclude with several recommendations for practice which collectively stress reconsidering what shared governance means on an individual campus and how it contributes to strategically thinking and articulately how shared involvement can play an important role in determining the future of a college.
Intravascular Lithotripsy in Acute Coronary Syndromes: Procedural and One‐Year Clinical Outcomes From the BENELUX‐IVL Registry
Authors: Oliveri Federico , van Oort Martijn J. H. , Al Amri Ibthial , Bingen Brian O. , Claessen Bimmer E. , Dimitriu‐Leen Aukelien C. , Kefer Joelle , Girgis Hany , Vossenberg Tessel , van der Van der Kley Frank , Jukema J. Wouter , Montero‐Cabezas Josè M. 
Published: November 2024

ABSTRACTBackgroundDespite the excellent success and safety of intravascular lithotripsy (IVL) in heavily calcified lesions, evidence in acute coronary syndromes (ACS) remains limited.AimsThis study aimed to evaluate the procedural and clinical outcomes of IVL in heavily calcified ACS.MethodsPatients who underwent IVL between 2019 and 2024 from the ongoing prospective BENELUX registry were eligible for inclusion. Patients were therefore classified in ACS and chronic coronary syndrome (CCS) groups. The primary technical endpoint was angiographic success < 30%, defined as the successful delivery of the IVL catheter across the target lesion and delivery of IVL pulses without angiographic complications and residual target lesion less than 30%. The primary clinical endpoint was in‐hospital major adverse cardiac events (MACE), including cardiac death, nonfatal myocardial infarction, or target lesion revascularization.ResultsA total of 454 patients underwent IVL, with 251 (55.3%) treated for CCS and 203 (44.7%) for ACS. The median SYNTAX score (p‐value 0.17), the need for inotropes (p‐value 0.09), and the use of mechanical circulatory support (p‐value 0.71) were similar between CCS and ACS groups. Comparable angiographic success (< 30% residual stenosis) was observed between CCS and ACS groups (90.1% vs. 91.1%, p = 0.69). MACE were similar across groups during hospital stays (CCS 1.6% vs. ACS 3.0%, p = 0.33), at 30 days (CCS 3.2% vs. ACS 3.9%, p = 0.86), and at 12‐month follow‐up (CCS 8.4% vs. ACS 7.9%, p = 0.91).ConclusionIVL provides high procedural success and consistent clinical outcomes in both CCS and ACS cases.
Acute Pancreatitis Associated With Systemic Lupus Erythematosus in a Young Female: A Diagnostic and Therapeutic Challenge
Authors: Ordoñes‐Saucedo Andres , Reyes‐Torres Bruno Eduardo , Kortright‐Maldonado Karen , Tenorio‐Aguirre Erika K. , Rodríguez‐Henríquez Pedro , Martínez‐Sánchez Froylan D. 
Published: November 2024

ABSTRACTAcute pancreatitis (AP) is a rare but life‐threatening complication in patients with systemic lupus erythematosus (SLE). The case highlights the diagnostic challenges and treatment complexities in managing SLE‐associated pancreatitis. A 20‐year‐old female with a history of SLE presented with acute onset epigastric pain, vomiting, and signs of systemic inflammation. Laboratory findings revealed elevated amylase and lipase levels, confirming AP. Imaging studies showed interstitial edematous pancreatitis and bilateral pleural effusion. The patient was managed with aggressive fluid resuscitation, pain management, and supportive care. A systemic inflammatory response complicated her clinical course, and she required intensive care unit monitoring. This case underscores the importance of early recognition of AP in SLE patients and highlights the need for a multidisciplinary approach to manage this severe complication.
Visible‐Light‐Mediated C−H Difluoroalkylation of (Hetero)arenes: A New Application of Vibration‐Induced‐Emission Molecule 9,14‐Diphenyl‐dihydrodibenzo[a,c]phenazine
Authors: Zhang Chengxi , Zhang Zhiyun , Chen Yifeng 
Published: November 2024

AbstractHerein, we report a vibration‐induced emission molecule, 9,14‐diphenyl‐dihydrodibenzo[a,c]phenazines (DPAC), compound‐catalyzed C−H difluoroalkylation of (hetero)arenes under visible light conditions. This method demonstrates the promising potential of vibration‐induced‐emission (VIE) molecules in photocatalysis and facilitates a metal‐free synthetic approach for difluoroalkyl (hetero)arenes with broad substrate scope and functional group tolerance.
Boron‐Containing Organic Two Dimensional Materials: Synthesis and Application
Authors: Zhao Fenggui , An Mengjie , Wang Nan , Yin Xiaodong 
Published: November 2024

AbstractOrganic two‐dimensional materials have garnered widespread attention due to their well‐defined structures, structural diversity, and rich electronic effects, demonstrating significant application potential across various fields. Atomic‐level manipulation of the structures of organic two‐dimensional materials has been a primary strategy for enriching and optimizing their properties. The introduction of heteroatoms often significantly affects their electronic structure, thereby endowing these materials with novel and unique properties. Boron atoms, due to their electron‐deficient nature, have been extensively studied in luminescent materials, semiconductor materials, and chemical sensing materials. Consequently, boron‐containing organic two‐dimensional materials are also believed to be promising as a new class of materials with excellent optoelectronic and chemical activities. This article collates and summarizes the preparation and property studies of three types of boron‐containing organic two‐dimensional materials in recent years.
Nucleophilic Amination of Aryl Halides with an Azanide Surrogate
Authors: Cooper Bradley D. , Harris Thomas D. , Lim Ethan R. X. , Hooper Katherine A. , Whitehead George F. S. , Carney Jonathan R. , James Michael J. 
Published: November 2024

AbstractWe report the development of an azanide (−NH2) surrogate which enables the facile conversion of electron‐deficient (hetero)aryl halides into primary N‐aryl amines under transition‐metal‐free conditions. The designed amidine reagent is easy to prepare, bench stable, and undergoes facile N‐arylation under basic conditions at 40 °C. Intermediate N‐aryl amidines are readily cleaved to form N‐aryl amines in situ through hydrolysis or base‐promoted elimination. The developed surrogate is a safer and more selective alternative to existing anionic N‐nucleophiles, such as alkali metal amides or azide salts.
Postconcussive symptom severity, risk factors for prolonged recovery, and mental health history: Pathways of influence in a diverse pediatric sample
Authors: Winstone‐Weide Laura K. , Gettig Kelly , Austin Cynthia A. 
Published: November 2024

AbstractIntroductionThe objective of this study was to confirm previous risk factors for concussion recovery in a diverse pediatric sample and to elucidate the pathways by which individual mental health factors influence postconcussive symptom reporting and time to clearance.MethodsSubjects between 13 and 17 years of age (N = 642; mean age = 15.40; 45% female) were analyzed from a prospectively completed database associated with a multidisciplinary TBI/concussion clinic in the southwest United States. Fifty‐four percent of participants identified as Hispanic, 41% received medical coverage through Medicaid, and 54% were injured during participation in an organized sports team. Mediation analysis using a structural equational framework was employed to examine the significance of both direct and indirect effects from preinjury factors (e.g., prior concussions, female gender, history of migraines, anxiety, depression, attention‐deficit/hyperactivity disorder [ADHD], and learning disorders) on postinjury symptom reporting (at baseline and visit 1) and time to clearance.ResultsHigher symptom reporting at baseline was significantly associated with history of anxiety, depression, ADHD, headaches, and female gender. Higher symptom reporting at visit 1 was significantly associated with baseline symptoms, female gender, and history of anxiety. Symptom scores at baseline fully accounted for the relation between history of depression and symptom scores at visit 1 and only partially accounted for the relation between history of anxiety and symptom scores at visit 1. Only history of anxiety indirectly contributed to greater days to clearance through higher symptom scores at visit 1.DiscussionThis study supports the concept that heterogenous experience following injury is influenced by preinjury factors and extends the generalizability of risk factors to a diverse sample of youth in terms of ethnicity, insurance status/type, and mechanism of injury. Anxiety and depression represent important noninjury factors that warrant considerable attention during concussion treatment and management.
Understanding the Effects of Surface and Edge Functionalization on the Mechanical Properties of Graphene and Graphene Oxide
Authors: Sharma Bharat Bhushan , Kedare Anjana , Muralidharan Girish , Govind Rajan Ananth 
Published: November 2024

AbstractGraphene oxide (GO) is a widely used 2D material employed in various applications due to its tunable properties. Understanding its mechanical properties is crucial to develop polymeric nanocomposites. We employ reactive molecular dynamics simulations to understand the effects of surface and edge functionalization of carbon atoms on the mechanical strength and fracture morphology of graphene and GO. We vary the extent of functionalization of hydroxyl and epoxy groups between 0.1 %–70 % on the GO surface and find that the tensile strength decreases with increasing functionalization. Nevertheless, there exists an optimal level of surface functionalization of 15–20 % where the tensile strength of pristine graphene is retained. Additionally, we find that functionalization alters the fracture morphology from brittle to mild ductile, which is desirable in engineering applications. We also show that the edge functionalization of finite‐size graphene nanosheets transfers the failure nucleation sites from the edges to the bulk, although the tensile strength decreases due to increased buckling. Interestingly, the decrement in tensile strength due to surface functionalization is larger as compared to edge functionalization. Overall, this work highlights the possibility of customizing GO's mechanical properties through targeted surface and edge functionalization, paving the way for its controlled application in nanocomposites.
Multicolor, Non‐Traditional Intrinsically Luminescent Polymers: Recent Advances
Authors: Chen Chen‐Xi , Cai Hua‐Wen , Sun Xiao‐Li , Wan Wen‐Ming , Huang Bao‐Quan 
Published: November 2024

AbstractLuminescent polymers have gained considerable research effects in different fields, which are generally prepared by incorporating traditional luminescent moieties. In recent years, non‐traditional intrinsic luminescent (NTIL) polymers containing no traditional luminescent moieties have been reported, which have attracted broad attention. This review summarizes recent advances in multicolor NTIL polymers, including stimuli‐responsive NTIL polymers, multicolor luminescence of NTIL polymers through polymerization‐induced emission strategy or molecular structure modulation, and the positive influence of through‐space charge‐transfer effect and hydrogen bonding construction strategy on NTIL polymers. This review on NTIL polymers may cause inspirations in different fields.
Computational Study on the Photo‐Induced Antibiotic Activity of an Azoquinolone with Promising Applications in Photopharmacology
Authors: Castro Pedro J. , Mendinueta Orlando D. , Mays Mary H. , Castro‐Gómez Fernando 
Published: November 2024

AbstractAzocompounds are among the most important group of molecular photoswitches due to their multiple applications in various scientific areas. We studied the thermal and photochemical reactions of an azocompound with photo‐induced antibiotic properties using ab‐initio calculations based on Kohn‐Shan, Spin‐Flip and time‐dependent Density Functional Theory. Our primary goal is to understand the absorption spectra and isomerization pathways governing the molecule's light‐controlled antibiotic activity. The nuclear ensemble approach was used for the most stable trans and cis isomers, and the absorption spectra were calculated and fitted to predict the cis/trans isomer ratios in the carboxylate form, using experimental measurements as a reference. We stablished that rotation is involved in the most favorable cis↔cis and trans↔trans thermal isomerization pathways, while the inversion mechanism is the most likely for cis↔trans isomerizations. We found that the photochemical trans→cis isomerization follows a consistent mechanism across all trans isomers, involving excitation to S2(ππ*), an in‐plane ultrafast internal conversion to S1(nπ*), followed by rotation of the azo bond up to a twisted S1(nπ*)/S0 conical intersection. We used a custom approach to evaluate the most favorable decay pathway from the S1(nπ*)/S0 conical intersections to trans and cis photoproducts using static calculations.
Advances and Challenges in the Development of Immobilized Enzymes for Batch and Flow Biocatalyzed Processes
Authors: Patti Stefania , Magrini Alunno Ilaria , Pedroni Sara , Riva Sergio , Ferrandi Erica Elisa , Monti Daniela 
Published: November 2024

AbstractThe development of immobilized enzymes both for batch and continuous flow biocatalytic processes has gained significant traction in recent years, driven by the need for cost‐effective and sustainable production methods in the fine chemicals and pharmaceutical industries. Enzyme immobilization not only enables the recycling of biocatalysts but also streamlines downstream processing, significantly reducing the cost and environmental impact of biotransformations. This review explores recent advancements in enzyme immobilization techniques, covering both carrier‐free methods, entrapment strategies and support‐based approaches. At this regard, the selection of suitable materials for enzyme immobilization is examined, highlighting the advantages and challenges associated with inorganic, natural, and synthetic organic carriers. Novel opportunities coming from innovative binding strategies, such as genetic fusion technologies, for the preparation of heterogeneous biocatalysts with enhanced activity and stability will be discussed as well. This review underscores the need for ongoing research to address current limitations and optimize immobilization strategies for industrial applications.
Elevated tau in the piriform cortex in Alzheimer's but not Parkinson's disease using PET‐MR
Authors: Moein Taghavi Hossein , Karimpoor Mahta , van Staalduinen Eric K. , Young Christina B. , Georgiadis Marios , Leventis Samantha , Carlson Mackenzie , Romero America , Trelle Alexandra , Vossler Hillary , Yutsis Maya , Rosenberg Jarrett , Davidzon Guido A. , Zaharchuk Greg , Poston Kathleen , Wagner Anthony D. , Henderson Victor W. , Mormino Elizabeth , Zeineh Michael 
Published: November 2024

AbstractINTRODUCTIONOlfactory dysfunction can be an early sign of Alzheimer's disease (AD). We used tau positron emission tomography‐magnetic resonance (PET‐MR) to analyze a key region of the olfactory circuit, the piriform cortex, in comparison to the adjacent medial temporal lobe.METHODSUsing co‐registered magnetic resonance imaging (MRI) and 18F‐PI‐2620 tau PET‐MR scans in 94 older adults, we computed tau uptake in the piriform‐periamygdaloid cortex, amygdala, entorhinal‐perirhinal cortices, and hippocampus.RESULTSWe found an ordinal cross‐sectional increase in piriform cortex tau uptake with increasing disease severity (amyloid‐negative controls, amyloid‐positive controls, mild cognitive impairment [MCI] and AD), comparable to entorhinal‐perirhinal cortex. Amyloid‐positive controls showed significantly greater tau uptake than amyloid‐negative controls. Negative correlations were present between memory performance and piriform uptake. Piriform uptake was not elevated in cognitively unimpaired Parkinson's disease.DISCUSSIONCross‐sectionally, there is an early increase in tau uptake in the piriform cortex in AD but not in Parkinson's disease.Highlights
Positron emission tomography–magnetic resonance (PET‐MR) analysis of the piriform cortex sheds light on its role as a potential early region affected by neurodegenerative disorders underlying olfactory dysfunction.
Uptake of tau tracer was elevated in the piriform cortex in Alzheimer's disease (AD) and mild cognitive impairment (MCI) but not in Parkinson's disease (PD).
Memory performance was worse with greater piriform uptake.