bluuebunny/crossref_metadata_2025_split huggingface dataset:
Population-based study of amyotrophic lateral sclerosis and occupational lead exposure in Denmark
Authors: Dickerson Aisha S , Hansen Johnni , Specht Aaron J , Gredal Ole , Weisskopf Marc G 
Published: January 2019

ObjectivesPrevious research has indicated links between lead (Pb) exposure and increased risk of neurodegenerative disorders, including amyotrophic lateral sclerosis (ALS). In this study, we evaluated the association between occupational Pb exposures and ALS.MethodsALS cases were ascertained through the Danish National Patient Registry from 1982 to 2013 and age and sex-matched to 100 controls. Using complete employment history since 1964 from the Danish Pension Fund, cumulative Pb exposure was estimated for each subject via a Danish job exposure matrix. Associations were evaluated using conditional logistic regression analyses and stratified by sex.ResultsFor men with >50% probability of exposure, there was an increase in odds of ALS for exposures in the 60th percentile or higher during any time 5 years prior to diagnosis (aOR: 1.35; 95% CI 1.04 to 1.76) and 10 years prior to diagnosis (aOR: 1.33; 95% CI 1.03 to 1.72). No significant associations were observed in women, and there were no linear trends seen for Pb exposures for either sex.ConclusionsOur study indicates an association between consistently higher occupational Pb exposures and ALS. These findings support those of previously reported associations between ALS and specific occupations that commonly experience Pb exposure.
Free fatty acids as a marker for predicting periprocedural myocardial injury after coronary intervention
Authors: Wang Yu , Zhang Hui-Wen , Guo Yuan-Lin , Zhu Cheng-Gang , Wu Na-Qiong , Li Jian-Jun 
Published: January 2019

AbstractBackgroundPrevious studies have revealed that plasma levels of free fatty acids (FFAs) are related to cardiovascular risk. However, whether FFAs could predict periprocedural myocardial injury (PMI) following percutaneous coronary intervention (PCI) in patients with stable coronary artery disease (CAD) remains unclear.PurposeThis study aimed to investigate the relationship of FFAs to PMI in untreated patients with CAD who underwent PCI.MethodsA total of 374 consecutive patients with CAD without lipid-lowering treatment on admission and with normal preprocedural cardiac troponin I (cTnI) levels who underwent PCI were prospectively enrolled. The baseline characteristics were collected and PMI was evaluated by cTnI analysis within 24 hours. The relation of preprocedural FFA levels to peak cTnI values after PCI was examined.ResultsPreprocedural FFAs were positively correlated with peak cTnI values after PCI in both simple regression model (β=0.119, p=0.021) and multiple regression model (β=0.198, p=0.001). Patients with higher FFA levels had higher postprocedural cTnI levels compared with those with normal FFA levels (0.27±0.68 ng/mL vs 0.66±0.31 ng/mL, p=0.014). In the multivariable model, preprocedural FFA levels were associated with an increased risk of postprocedural cTnI elevation above 1× upper limit of normal (ULN, OR: 1.185, 95% CI 0.997 to 1.223, p=0.019) up to 10× ULN (OR: 1.132, 95% CI 1.005 to 1.192, p=0.003) .ConclusionsThe present study first suggested that elevated FFA levels were associated with an increased risk of PMI in untreated patients with CAD. Further study with large sample size may be needed to confirm our findings.
Medicaid payer status is associated with increased mortality and morbidity after inpatient shoulder arthroplasty: a multistate analysis, 2007–2014
Authors: Like Brian J , White Robert S , Tangel Virginia , Sullivan Kathleen J , Arroyo Noelle S , Stambough Jeffrey B , Turnbull Zachary A 
Published: January 2019

Background and objectivesInpatient shoulder arthroplasty is widely performed around the USA at an increasing rate. Medicaid insurance has been identified as a risk factor for inferior surgical outcomes. We sought to identify the impact of being Medicaid-insured on in-hospital mortality, readmission, complications, and length of stay (LOS) in patients who underwent inpatient shoulder arthroplasty.MethodsWe analyzed 89 460 patient discharge records for inpatient total, partial, and reverse shoulder arthroplasties using data from the Healthcare Cost and Utilization Project’s State Inpatient Databases for California, Florida, New York, Maryland, and Kentucky from 2007 through 2014. We compared patient demographics, present-on-admission comorbidities, and hospital characteristics by insurance payer. We estimated multilevel mixed-effect multivariate logistic regression models and generalized linear models to assess insurance’s effect on in-hospital mortality, readmission, infectious complications, cardiac complications, and LOS; models controlled for patient and hospital characteristics.ResultsMedicaid-insured patients had greater odds than patients with private insurance, other insurance, and Medicare of inpatient mortality (OR: 4.61, 95% CI 2.18 to 9.73, p<0.001) and 30-day and 90-day readmissions (OR: 1.94, 95% CI 1.57 to 2.38, p<0.001; OR: 1.65, 95% CI 1.42 to 2.38, p<0.001, respectively). Compared with private insurance, other insurance, and Medicare patients, Medicaid patients had increased likelihood of developing infectious complications and were expected to have longer LOS.ConclusionsOur study supports our hypothesis that among inpatient shoulder arthroplasty patients, those with Medicaid insurance have worse outcomes than patients with private insurance, other insurance, and Medicare. These results are relatively consistent with previous findings in the literature.
Pain management after laparoscopic hysterectomy: systematic review of literature and PROSPECT recommendations
Authors: Lirk Philipp , Thiry Juliette , Bonnet Marie-Pierre , Joshi Girish P , Bonnet Francis 
Published: February 2019

Background and objectivesLaparoscopic hysterectomy is increasingly performed because it is associated with less postoperative pain and earlier recovery as compared with open abdominal hysterectomy. The aim of this systematic review was to evaluate the available literature regarding the management of pain after laparoscopic hysterectomy.Strategy and selection criteriaRandomized controlled trials evaluating postoperative pain after laparoscopic hysterectomy published between January 1996 and May 2018 were retrieved, according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, from the EMBASE and MEDLINE databases and the Cochrane Register of Controlled Trials. Efficacy and adverse effects of analgesic techniques were assessed.ResultsOf the 281 studies initially identified, 56 were included. Of these, 31 assessed analgesic or anesthetic interventions and 25 assessed surgical interventions. Acetaminophen, non-steroidal anti-inflammatory drugs, and dexamethasone reduced opioid consumption. Limited evidence hindered recommendations on alpha-2-agonists. Inconsistent evidence was found in the studies investigating pregabalin and transversus abdominis plane block, and no evidence was found for intraperitoneal local anesthetics, port site infiltration, or single-port laparoscopy. Measures to lower peritoneal insufflation pressure or humidify or heat insufflated gas seem to reduce the incidence of shoulder pain, but not abdominal pain.ConclusionsThe baseline analgesic regimen for laparoscopic hysterectomy should include acetaminophen, a non-steroidal anti-inflammatory drug, dexamethasone, and opioids as rescue analgesics.
Prevalence and risk factors of anogenital human papillomavirus infection in a community sample of men who have sex with men in Taiwan: baseline findings from a cohort study
Authors: Strong Carol , Zou Huachun , Ko Nai-Ying , Liang Ya-Lun , Ku Wen-Wei , Lee Chia-Wen 
Published: January 2019

ObjectivesMen who have sex with men (MSM) are a highly neglected population in the current recommendation of girls-only human papillomavirus (HPV) vaccination programmes in many countries. To better assess the cost effectiveness of HPV vaccination among men requires data on the prevalence of HPV infection in MSM using a community sample, which is still sparse in several regions. We examined the prevalence of and factors associated with anogenital HPV infection among MSM in Taiwan.MethodsMSM 20 years of age and older were recruited from the community and social media in Taiwan in 2015–2016 and screened for HPV infection to detect 37 genotypes. MSM were seen at baseline and were/will be seen at 6, 12, 24 and 36 months. Men completed a questionnaire regarding their sexual experiences. Multivariable regression analyses were conducted to identify associated behavioural risk factors using the baseline data.ResultsA total of 253 MSM were recruited; 87 % were below 35 years of age. Diagnosis of HIV was reported in 4% of men; just over 20% had three or more anal sex partners in the past year. The prevalence of any tested HPV type was 29.4% at the anal site and 11% at the penile site. One quarter of MSM were infected with any of the 9-valent vaccine HPV types. Anal HPV detection was associated with having three or more receptive anal sex partners in the past year (adjusted odds ratio (aOR)=2.92, 95% CI 1.29 to 6.61) and having older sex partners (aOR=2.51, 95% CI 1.07 to 5.90).ConclusionsOur data provide the base to calculate the reproductive rate for HPV transmission in a low-risk community sample and cost-effectiveness to include men in HPV vaccination policies. Adding evidence from a community sample adds comprehensiveness for future estimates of disease transmission and vaccine effectiveness.
Delphi study among international expert panel to develop waterpipe-specific health warning labels
Authors: Asfar Taghrid , Schmidt Michael , Ebrahimi Kalan Mohammad , Wu Wensong , Ward Kenneth D , Nakkash Rima T , Thrasher James , Eissenberg Thomas , Ben Romdhane Habiba , Maziak Wasim 
Published: January 2019

BackgroundWaterpipe (WP) smoking is increasing globally. The rise of WP has been fuelled by widespread misperception of reduced-harm compared to cigarettes. Health warning labels (HWLs) are one strategy to communicate smoking-related risks and address reduced-harm misperceptions. Therefore, the development of WP-specific HWLs represents a priority for WP control.MethodsA panel of experts in WP science developed 28 WP-specific HWLs corresponding to five themes (health risks, addiction, harm to others, WP-specific harm, WP harm compared to cigarettes). Subsequently, a three-round Delphi study was conducted among international expert panel to reach consensus on a set of the most effective HWLs for each theme. Levels of agreement between participants were assessed using interquartile deviations, and the rank between the tied HWLs was based on the median.ResultsStarting with 28 candidate HWLs stratified according to five WP-related themes, our international expert panel reached consensus on the 13 most important WP-specific HWLs. Labels with the highest agreement were related to oral and heart disease, WP’s harmful effects on newborn children and the amount of smoke inhaled from WP compared to cigarettes.ConclusionThis study is the first to systematically develop and evaluate potential WP-specific HWLs based on the scientific evidence about WP’s harmful effects, scientific understanding of HWL for cigarettes and the opinions of experts in WP science, tobacco control and health communication. The final selected HWLs can be adapted based on the context and policy landscape of the target country and can be further fine-tuned based on feedback from WP smokers and non-smokers.
Co-tame polynomial automorphisms
Authors: Edo Eric , Lewis Drew 
Published: January 2019

A polynomial automorphism of [Formula: see text] over a field of characteristic zero is called co-tame if, together with the affine subgroup, it generates the entire tame subgroup. We prove some new classes of automorphisms of [Formula: see text], including nonaffine [Formula: see text]-triangular automorphisms, are co-tame. Of particular interest, if [Formula: see text], we show that the statement “Every [Formula: see text]-triangular automorphism is either affine or co-tame” is true if and only if [Formula: see text]; this improves upon positive results of Bodnarchuk (for [Formula: see text], in any dimension [Formula: see text]) and negative results of the authors (for [Formula: see text], [Formula: see text]). The main technical tool we introduce is a class of maps we term translation degenerate automorphisms; we show that all of these are either affine or co-tame, a result that may be of independent interest in the further study of co-tame automorphisms.
Single-Cell Profiling of Cutaneous T-Cell Lymphoma Reveals Underlying Heterogeneity Associated with Disease Progression
Authors: Borcherding Nicholas , Voigt Andrew P. , Liu Vincent , Link Brian K. , Zhang Weizhou , Jabbari Ali 
Published: February 2019

Abstract

Purpose:
Cutaneous T-cell lymphomas (CTCL), encompassing a spectrum of T-cell lymphoproliferative disorders involving the skin, have collectively increased in incidence over the last 40 years. Sézary syndrome is an aggressive form of CTCL characterized by significant presence of malignant cells in both the blood and skin. The guarded prognosis for Sézary syndrome reflects a lack of reliably effective therapy, due, in part, to an incomplete understanding of disease pathogenesis.

Experimental Design:
Using single-cell sequencing of RNA and the machine-learning reverse graph embedding approach in the Monocle package, we defined a model featuring distinct transcriptomic states within Sézary syndrome. Gene expression used to differentiate the unique transcriptional states were further used to develop a boosted tree classification for early versus late CTCL disease.

Results:
Our analysis showed the involvement of FOXP3+ malignant T cells during clonal evolution, transitioning from FOXP3+ T cells to GATA3+ or IKZF2+ (HELIOS) tumor cells. Transcriptomic diversities in a clonal tumor can be used to predict disease stage, and we were able to characterize a gene signature that predicts disease stage with close to 80% accuracy. FOXP3 was found to be the most important factor to predict early disease in CTCL, along with another 19 genes used to predict CTCL stage.

Conclusions:
This work offers insight into the heterogeneity of Sézary syndrome, providing better understanding of the transcriptomic diversities within a clonal tumor. This transcriptional heterogeneity can predict tumor stage and thereby offer guidance for therapy.
Abstract A01: Standardizing tracking and evaluation in cancer disparities research: Utilizing REDCap to track training, education, and community engagement activities
Authors: Chukwudozie Ifeanyi Beverly , Watson Karriem S. , Rhodes Stacey , Al-Kodmany Ahlam , Martinez Erica , Gay Christopher , Fitzgibbon Marian L. , Grippo Paul , Winn Robert A. , Winn Robert A. 
Published: February 2019

Abstract
The Center to Reduce Cancer Health Disparities (CRCHD) of the National Cancer Institute (NCI) is dedicated to enhancing the diversity of the scientific workforce through training and education and supporting community engagement. The utilization of standardized tools to track and assist in the evaluation of outcomes from training, education, and community engagement programs is important to grants supported by the CRCHD. This case study describes the utilization of a readily available and secure web-based electronic tool, REDCap (Research Electronic Data Capture), to broadly track and evaluate community engagement activities and training and education milestones in an Academic Cancer Center. Aim 1 describes the online survey tool created in REDCap to track all community engagement activities for the Cancer Center. Aim 2 describes methods and assessment tools created to track and evaluate mentoring relationships, training, educational activities, and career outcomes of trainees in an emerging cancer center seeking NCI designation. Training programs in the University of Illinois (UI) Cancer Center occur across the pipeline and target high school and undergraduate students, graduate and pre- and post-doctoral students, and early-stage investigators with a focus on populations under-represented in health disparities research. The utilization of REDCap will allow outcomes from NCI CRCHD funded programs and other training, education, and community engagement programs to uniformly track outcomes and assess efficacy to ensure alignment with NCI priorities for cancer centers in community engagement and training and education. Our case study supports the NIH's efforts to ensure longitudinal tracking of training and education programs for a minimum of 10 years and to ensure community engagement targeting the cancer center's catchment area. This case study can provide generalizable information to other cancer centers and NCI CRCHD awardees.
Citation Format: Ifeanyi Beverly Chukwudozie, Karriem S. Watson, Stacey Rhodes, Ahlam Al-Kodmany, Erica Martinez, Christopher Gay, Marian L. Fitzgibbon, Paul Grippo, Robert A. Winn, Robert A. Winn. Standardizing tracking and evaluation in cancer disparities research: Utilizing REDCap to track training, education, and community engagement activities [abstract]. In: Proceedings of the Tenth AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2017 Sep 25-28; Atlanta, GA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2018;27(7 Suppl):Abstract nr A01.
Abstract A10: Using cluster analysis to explore heart age among cancer survivors in Alabama
Authors: Vo Jacqueline B. , Raju Dheeraj , Meneses Karen 
Published: February 2019

Abstract
Introduction: More than 223,000 cancer survivors reside in Alabama. The five-year survival rate of all cancer survivors is approximately 67%. Cancer treatment and behavioral risk factors may contribute to increased cardiovascular disease risk among cancer survivors. Heart age estimates cardiovascular disease risk using chronologic age, systolic blood pressure, smoking status, diabetes status, antihypertensive use, height, and weight. The purpose of this poster is to explore heart age in Alabama using cluster analysis.
Methods: Data were from the CDC-established Behavioral Risk Factor Surveillance System using Alabama years 2011 and 2013. Records were included if between ages 30-74 years. Cluster analysis uses a k-means clustering algorithm to fit the data. The first step is to identify optimal number of clusters based on similar properties (e.g., chronologic age, heart age, and body mass index) using the plot within cluster error. The second step is to assess the plot using the “elbow method” by selecting the optimal number of clusters based on the “elbow.” SAS 9.4, SUDAAN 11.0.1, and RStudio 3.2.3 were used to conduct statistical analyses.
Results: Four clusters were identified. Cluster 1 (n = 2,523) comprised older participants (66 years), who had a higher heart age (86 years) and overweight body mass index (28). Cluster 1 included 50% of the cancer survivor participants. Cluster 2 (n = 2,088) and Cluster 3 (n = 2,405) were younger (means of 39 and 55) with a lower excess heart age (means of 2 and 6) and overweight body mass index (28 and 25). Cluster 4 (n = 1,137) participants were middle-aged (mean 54 years), mean excess heart age of 22 years, morbidly obese, 42% non-Hispanic Blacks, and high self-report rate of diabetes (33%).
Discussion: Cluster analysis provides for additional data not found through mean comparison tests. Obesity is not a sole factor in increased cardiovascular disease risk among cancer survivors. Cancer treatment, not accounted for in heart age calculations, may contribute to risk. Additionally, middle-aged Alabama residents in Cluster 4 may be at risk for both cancer and cardiovascular disease. Future considerations may include creating a cancer-specific heart age tool.
Citation Format: Jacqueline B. Vo, Dheeraj Raju, Karen Meneses. Using cluster analysis to explore heart age among cancer survivors in Alabama [abstract]. In: Proceedings of the Tenth AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2017 Sep 25-28; Atlanta, GA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2018;27(7 Suppl):Abstract nr A10.
Abstract A28: Current and future incidence rates of invasive breast cancer between Black and White women
Authors: Lynn Brittny C. Davis , Rosenberg Philip S. , Anderson William F. 
Published: February 2019

Abstract
Background: Though incidence rates for invasive breast cancer overall have been historically lower for Black than White women, recent reports show that rates have converged between the two groups. We used the age-period-cohort framework to verify the current trends and to forecast future implications.
Methods: Data from Surveillance, Epidemiology, and End-Results (SEER) Program 13 registries and the age-period-cohort forecasting model were used to observe current incidence rates (1992 to 2014) and to predict future trends (2015 to 2030) of invasive breast cancer by ER status among non-Hispanic White, Hispanic, and Black women, ages 30 to 84 years. Trends in the age-standardized incidence rate (ASR) were quantitated with the estimated annual percentage change (EAPC) in the ASR.
Results: Observed invasive breast cancer incidence rates from 1992 through 2014 show convergence between White and Black women but not between non-Hispanic White and Black women. Observed incidence rates for ER-positive breast cancer are rising for all races, but rising faster among Black women with an EAPC = 0.77 [0.26, 1.29] %/year. In contrast, observed incidence rates for ER-negative breast cancer are decreasing for all races, but decreasing slower among Black women with an EAPC = -2.00 [-2.55, -1.43] %/year. Forecasting for ER-positive and ER-negative breast cancers suggests a continuation of the observed trends without future convergence in overall breast cancer rates.
Conclusions: Incidence rates between Black and White women did not converge when non-Hispanic White women were separated from Hispanic White women. Whenever possible, future comparative breast cancer analyses should always attempt to analyze discrete populations separately, given the complexities of differential risk factor exposures by race and/or ethnicity. A better understanding of breast cancer in general and by race may be accomplished by accurately describing the similarities and disparities among different ethnic groups.
Citation Format: Brittny C. Davis Lynn, Philip S. Rosenberg, William F. Anderson. Current and future incidence rates of invasive breast cancer between Black and White women [abstract]. In: Proceedings of the Tenth AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2017 Sep 25-28; Atlanta, GA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2018;27(7 Suppl):Abstract nr A28.