bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fission Yeast CENP-C (Cnp3) Plays a Role in Restricting the Site of CENP-A Accumulation
Authors: Suma Michiko , Kitagawa Teppei , Nakase Yukiko , Nakazawa Norihiko , Yanagida Mitsuhiro , Matsumoto Tomohiro 
Published: June 2018

Abstract
The centromere is a chromosomal locus where a microtubule attachment site, termed kinetochore, is assembled in mitosis. In most eukaryotes, with the exception of holocentric species, each chromosome contains a single distinct centromere. A chromosome with an additional centromere undergoes successive rounds of anaphase bridge formation and breakage, or triggers a cell cycle arrest imposed by DNA damage and replication checkpoints. We report here a study in Schizosaccharomyces pombe to characterize a mutant (cnp3-1) in a gene encoding a homolog of mammalian centromere-specific protein, CENP-C. At the restrictive temperature 36°, the Cnp3-1 mutant protein loses its localization at the centromere. In the cnp3-1 mutant, the level of the Cnp1 (a homolog of a centromere-specific histone CENP-A) also decreases at the centromere. Interestingly, the cnp3-1 mutant is prone to promiscuous accumulation of Cnp1 at non-centromeric regions, when Cnp1 is present in excess. Unlike the wild type protein, Cnp3-1 mutant protein is found at the sites of promiscuous accumulation of Cnp1, suggesting that Cnp3-1 may stabilize or promote accumulation of Cnp1 at non-centromeric regions. From these results, we infer the role of Cnp3 in restricting the site of accumulation of Cnp1 and thus to prevent formation of de novo centromeres.
Building Academic Communities to Support Nursing Students with Disabilities: An Integrative Review
Authors: Neal-Boylan Leslie , Miller Michelle , Bell Jessica 
Published: June 2018

Background: Students with disabilities in higher education are increasing, yet discrimination against nurses and nursing students with disabilities persists. A healthy academic community must include students with disabilities who are receiving accommodations per the ADAAA.Aim: To determine the extent, if any, of progress in accommodating nursing students with disabilities since the enactment of the Americans with Disabilities Act Amendment (ADAAA) of 2008. Methods: An integrative review of peer-reviewed literature written in English was conducted. The Cumulative Index to Nursing & Allied Health Literature (CINAHL), PubMed, and Educational Resources Information Center (ERIC) were searched. The date range spanned from 2008 to 2018. The type of peer-reviewed literature was not specified.Results: Accommodating students with disabilities depends on individual faculty who remain concerned about patient safety. Faculty tend to view students with disabilities using a medical rather than a social model and evaluate students on the ability to perform essential functions of the job instead of on student competencies.Conclusions: Faculty are more aware of the needs of nursing students with disabilities and the need to accommodate them, yet discrimination still occurs. Academic communities must not discriminate against students with disabilities and should structure an interdisciplinary approach that includes assistance from the university disability office, education of faculty about the ADAAA and the development of sustainable educational models that integrate the individualized needs of all learners.
Peripartum type A dissection: a case report
Authors: SANRI Umut Serhat , ÖZSİN Kadir Kaan , TOKTAŞ Faruk , YAVUZ Şenol 
Published: June 2018

Aortic
dissection is a rare but potentially lethal complication during pregnancy in
young women and usually diagnosis could be overlooked. We reported a
40-year-old postpartum female with aortic dissection which developed in
peripartum period. She complained of interscapular back pain and chest pain. The
patient's pain had continued after
caesarean section. She admitted to our clinic six days after this intervention.
Contrast-enhanced computed tomography revealed the aortic dissection. Hemiarch replacement performed successfully and the
patient discharged uneventfully despite of delayed diagnosis.
Global tendencies in pork meat - production, trade and consumption
Authors: Szűcs István , Vida Viktoria 
Published: June 2018

World meat production is anticipated to stagnate in 2016, rising by a mere 0.3% to 320.7 million tonnes. Increases in output are expected in the United States, Brazil, the EU, India and the Russian Federation, while reduced production is foreseen for China, Australia and South Africa. Global meat trade is forecast to recover in 2016, growing by 2.8% to 30.6 million tonnes, which would represent a return to trend, after a fall in 2015. World production of pig meat in 2016 is forecast to decrease marginally, by 0.7% to 116.4 million tonnes, thus registering a second year of virtual stagnation. As in 2015, lower output in China, which accounts for almost half the world total, is the main reason for the slowdown. An unfavourable feed-pork price ratio in the country and new environmental regulations have caused farmers to reduce breeding sows, stalling growth. China’s production is projected to be 54 million tonnes, down 2.5% from the previous year. Elsewhere in Asia, the Philippines and Vietnam could boost output. Also, production in Japan and the Republic of Korea may expand, as the industry recovers from outbreaks of PED, which reduced piglet numbers in the previous two years. Recovery from the effects of PED has been faster in the United States, where a second year of growth is anticipated, when production could increase by 1.9% to a record 11.3 million tonnes. Output in Mexico also continues to recover, following a PED outbreak in 2014, and may rise in 2016 by 2.0% to 1.3 million tonnes. Pork meat trade could experience a second year of growth, increasing by 4.4% to 7.5 million tonnes – a record level. Lower international prices have stimulated trade. Most of the principal importing countries are anticipated to increase their purchases, including Mexico, China, the Russian Federation, the United States, Japan, the Republic of Korea and Australia. In response to rising demand, exports are projected to grow, in particular those of the United States, Canada, the EU and Brazil (FAO, 2016). Summarizing, in this study we wish to examine how evolve the world pork meat production, trade and consumption, and to demonstrate the main consuming countries, highlighting the role of China, as it is the most populated country in the world with its 1.4 billion inhabitants.
JEL Code: Q13, Q12
Analysis the advanced ICT usage of the Hungarian SME sector for preparing a domestic agri-food research
Authors: Botos Szilvia , Felföldi János , Várallyai László , Péntek Ádám , Szilágyi Róbert 
Published: June 2018

In the Hungarian agro-food sector SMEs have a key role but regarding the tendency of the performance of SME sector, comparing to EU-28 average, the performance of Hungarian SME sector has gradually worsened between 2008 and 2015 while the EU average has an increasing trend. ICT can help enterprises and this article is an overview of the ICT situation of Hungarian SMEs. It is important to analyse in detail the ICT usage characteristics of agro SMEs in the food supply chain because these ICT devices, tools and services are crucial to smooth the information flow within the chain. For all these reasons our work aims to find out how Hungarian agro-food SMEs use ICT and how ICT adoption affect their business procedures, performance and development. A striking observation to emerge from the data comparison is the difference among SMEs and large enterprises regarding the usage of the different basic and advanced ICT solutions. A much bigger percent of large companies use advanced ICT then SMEs and mainly small enterprises are lagging behind as the attitudes of medium sized enterprises are rather similar to the large ones. In Hungary small enterprises in agro-food industry are in difficult financial state and for them free Cloud Computing services can offer good opportunities as they do not have initial costs. ICT adoption is very important to them as ICT sector is a dynamically growing sector and if customers and partners of an enterprise adapt faster to these technological innovations, it may have a negative effect on the different processes, performance and financial results of the organisation. In this article our aim was to determine the main question groups for our questionnaire which focus mainly on ICT solutions supporting the quality of communication and relationship between partners. As the basic IT tools are available in the major part even in the SMEs besides large companies, the two main issues will be the usage of advanced online services and the usage of high quality ICT solutions.
JEL Code: M15
Human resource aspect of agricultural economy – challenges of demographic change
Authors: Rajczi Alexandra , Vörös Péter , Dajnoki Krisztina 
Published: June 2018

Over the past decades, the agrarian policy has tried to contribute to the catching-up of the rural areas with varying dynamism and aid scheme. However, its result is significantly below expectations. Nowadays, the age composition of the population living in rural areas reveals an unfavourable picture; the rate of the elderly, deprived persons and people being inactive from the aspect of employment is high and it is also combined with the low educational levels. The young generations and intellectuals leave the rural areas and, consequently, the rate of the active population continues to grow narrow as well as the proportion of young and skilled employees decreases. As a consequence of changes in the past decades, the rate of agricultural employment has not led to an intensive change but a failing change in extensive direction which lays off jobs. Nowadays, this process also determines the Hungarian rural society. In the sector, the need for employment diminishes as a result of the development in technology and due to the expansion of services sector. The purpose of our study is to present and analyse the human resources of our country’s agriculture by skill level and age group and compare it with the needs of companies, by doing this we try to compare supply and demand. In details, based on secondary data source, we investigate the agricultural labour force and try to confront it with the advertisements of job search portals (three of our job search portals based on our predefined criteria), by which we achieve a current picture of the agricultural human resource circumstances.
JEL Code: J43
Demographic and lifestyle attributes with a fundamental role in food supplement consumption (exploratory research)
Authors: Nábrádi Zsófia 
Published: June 2018

The worldwide proportion of food supplement consumers has been steadily increasing, more than 50% of the Hungarian population tends to buy at least one type of dietary supplement. In most cases, the purchase and consumption of food supplements are not based on medical indications but depends on consumers’ individual decisions. The study of consumer groups enables the investigation of typicalities which have an impact on attitudes related to the consumption of food additives. The present study explores the demographical factors determining the global consumption of dietary supplements by secondary research. It sought to explore the typical features of consumer lifestyles in line with the research findings, based on previously specified criteria, through qualitative focus group examinations. My study focused on subjects who bought and purchased at least one type of food supplement in the previous year and placed a high emphasis on healthy diet and lifestyle in their everyday lives. The consumption of dietary supplements indicates growth with age and it is more common among women. Consumers with higher qualifications and incomes tend to buy products with vitamins and minerals in a greater proportion. The identification of nutrition factors revealed that the proportion of those who do not need extra nutrient intake is high among food supplement consumers. It is primarily true of women having a healthy lifestyle (they typically consume high amounts of vegetables and fruits, they are physically active, non-smokers and do not use alcohol); moreover, their socio-economic status is typically high. The findings of my quantitative research suggest that the purchase and consumption of dietary supplements are most characteristic of the “Successful”, “Quality oriented- successful” and “Loyal to the brand - modest” groups in the lifestyle-based consumer segments. The investigated sample showed ambiguous attitudes towards product quality and willingness to pay in all the three batches. Nevertheless, it can be established, when consumers buy food supplements, brand sensitivity proves to be a dominant factor in addition to - typically Hungarian - price sensitivity. Based on lifestyle factors, the current research may bring us closer to the exploration of the motivational and attitude patterns of consumers’ food supplement purchases.
JEL Code: I12, M31
Reasons for and obstacles to cycling in opinions of residents of Debrecen, Hungary
Authors: Kosztin Nikolett , Tőzsér József , Csernoch László , Balatoni Ildikó 
Published: June 2018

It is a basic aim of the European Union that due to the developments in 2014-2020 the bicycle would become one of the most often used transportation, touristic, and sports equipment. We were interested to see to what extent is bicycling present in the transportation system of Debrecen and what are the most important reasons for its residents to use the bicycles. The dedication of Debrecen to promote cycling is clearly proven by the number of newly built or resurfaced bike paths and by the fact that the University of Debrecen has introduced – alone in the region – UniBike which is a bicycle renting system brought forth by the need of its students. Here we present the developments that took place in the North Plain Region in the past few years. We have also analyzed the national and European strategies and reports on bicycling. A survey was conducted among the youth of Debrecen to explore their cycling habits. The data were evaluated using the EvaSys program. Until the end of 2011 with the help of different funds 862 km of bike paths had been built in Hungary. In the North Plain Region due to funds totaling 777 million HUF 15.7 km long bike paths had been constructed until 2015. The development of tourism in this direction is promoted by the web-pages and brochures offering bicycle-tours around Debrecen. Nevertheless, bicycling in the neighboring townships is present not as an instrument for sports and/or tourism, rather as a mean of transportation. It is a clear goal in Europe and thus in Hungary to have bike paths that can provide the means of safe cycling. In parallel, it is also important to promote the benefits of bicycling, including positive physiological effects, cost-effectiveness, and environment-friendliness to increase the proportion of those who select bicycling as an alternative.
JEL Code: I15
Dynamic Effects of Two-Time Delays on a Model for Tumor Growth
Authors: Liu Haihong , Guo Lina , Yan Fang , Zhang Linghai 
Published: June 2018

Aims and Objective: In order to understand the dynamic mechanisms of tumor growth
and make a contribution to develop anti-cancer treatment strategies, a mathematical model for tumor
growth with two-time delays is proposed in this article.

Materials and Methods:
First, the relationships among host cells, tumor cells and effector cells, and
the biological meaning of two-time delays are explained. Moreover, the system stability is discussed
by analyzing the characteristic equation of the model. In addition, the existence and properties of
oscillatory dynamic are also researched by using normative theory and central manifold method.
Finally, the numerical simulations are performed to further illustrate and support the theoretical
results.

Results:
Both two-time delays in the model can affect the dynamics of tumor growth. Meanwhile,
the system can experience a Hopf bifurcation when the delay crosses a series of critical values.
Further, a clear formula is deduced to determine the Hopf bifurcation and the direction of stability of
the periodic solution. Finally, these results are verified by using numerical simulation.

Conclusion:
The results demonstrated that the time from identifying tumor cells to making the
appropriate response for the immune system and the time needed for competition between host cells
and tumor cells for natural resources and living space is significant for tumor growth. These findings
in this paper may help us better understand the behaviors of tumors and develop better anti-cancer
treatment strategies.
Non-invasive Cerebellar Stimulation in Cerebellar Disorders
Authors: Di Nuzzo Chiara , Ruggiero Fabiana , Cortese Francesca , Cova Ilaria , Priori Alberto , Ferrucci Roberta 
Published: June 2018

Background & Objective:
Non-invasive brain stimulation (NIBS) might be a valuable
therapeutic approach for neurological diseases by modifying the cortical activity in the human brain
and promoting neural plasticity. Currently, researchers are exploring the use of NIBS on the cerebellum
to promote functional neural changes in cerebellar disorders.

Conclusion:

In the presence of cerebellar dysfunction, several movement disorders, such as kinetic tremor, ataxia
of gait, limb dysmetria and oculomotor deficits, become progressively more disabling in daily life, and
no pharmacological treatments currently exist.

Conclusion:
In the present mini-review, we report the main evidence concerning the use of NIBS in
three specific cerebellar dysfunctions, cerebellar ataxias (CA), essential tremor (ET) and ataxic cerebral
palsy, in which abnormalities of neuroplasticity and cortical excitability can be important pathophysiological
factors.
HIV Testing Among Women of Reproductive Age Exposed to Intimate Partner Violence in Uganda
Authors: Salima Nanyanzi , Leah Emegwa , Stephen Lawoko 
Published: June 2018

Background:Intimate Partner Violence (IPV) and Human Immunodeficiency Virus and Acquired Immune Deficiency Syndrome (HIV/AIDS) occur as dual epidemics with gender dimensions. IPV sometimes result in lack of decision making autonomy over one’s own health and this may negatively affect uptake HIV testing services.Objective:The study aimed to examine the association between exposure to IPV and HIV testing among women of reproductive age in Uganda.Method:The study is based on cross-sectional data from 2011 Uganda Demographic and Health Survey (UDHS). A sub-sample of 1705 ever-partnered women aged 15-49 who responded to the domestic violence module was examined in the study. Bivariate and multivariable (logistic regression) analyses were used to determine the association between exposure to IPV and HIV testing.Results:Up to 82.3% and 61.5% of the respondents were tested for HIV ever and in the past year, respectively. The prevalence of physical IPV and IPV of any form in the past year was 25.6% and 44% respectively. Exposure to physical IPV and emotional IPV in the past year was associated with HIV testing within the past year. In the multivariate analysis, exposure to physical IPV remained significantly associated with HIV testing within the past year (OR: 1.34; 95% CI: 1.03-1.73). Frequent access to newspapers remained a significant predictor of HIV testing uptake.Conclusion:HIV testing in the past year is associated with exposure to IPV among women of reproductive age in Uganda. There is a need to include IPV as a part of global strategy to address HIV/AIDS.
THE EFFECTS OF THE RESISTANCE TRAINING ON SERUM CORTISOL, IL-6, IL-8, AND TNF- α
Authors: Öztürk Yılmaz , DİNÇ Nurten , Bereket Yücel Selda , Taneli Fatma , Ulman Cevval , Tıkız Hakan 
Published: June 2018

Objective: The purpose of this study is to investigate effects of resistance training on IL-6, IL-8, TNF-α, blood hematocrit and cortisol levels.
Materials and Methods: Thirteen players from Manisa Celal Bayar University soccer team and 14 sedentary male students were used as the study subjects. The subjects, whose average age was 18-24 years old, were healthy and free of any cardiovascular diseases. Anthropometrics measurements and blood samples were obtained from all the subjects. Blood samples were obtained basal sample (before the exercise), immediately after the training program (post-exercise), and 2 hours after the training program (2h post-exercise). All subjects participated in the training program in which intensity prescribed individually in 10 different exercises; seated leg press, knee extension, knee flexion, chest press, chest flys, lat pull down, shoulder press, triceps extension, biceps curl and sit-ups. Three sets of intensity of the each exercise were arranged according to pyramidal system at 70-80 % of the each participant. The volume of resistance training was 50-60 minutes.
Results: Post exercise IL-6 (p= 0,05) and IL-8 (p= 0,04) concentration of athletes were statistically lower compared to that of sedentary group. Furthermore, serum cortisol concentrations were found to be decreased in both study groups in post exercise and 2h post exercise samples compared to basal values (p<0,05). Post exercise IL-8 (p=0,04) and TNF-α (p=0,04) values of sedentary group increased significantly compared to values at 2h post exercise.
Conclusion: IL-6, IL-8, and TNF-α responses to resistance training vary depending on the recruitment of different muscle fiber types by the trained individuals during the resistance training and the recovery of glycogen storage, which is found to be different from that of sedentary individuals.
Development of the ability to differentiate the parameters of football players' movements taking into account their typology
Authors: Polevoy Georgiy 
Published: June 2018

The purpose of this article - to receive and generalize the data obtained in a new research namely change of indicators of ability to differentiation of parameters of movements of the young football players having different typology of nervous system.
The leading method of studying this problem is a pedagogical experiment, as well as a theoretical analysis of methodological literature and the use of methods of mathematical statistics.
The result is an improvement in the indices of the ability to kinesthetic differentiation of the parameters of soccer player movements of 12-13 years, after applying an experimental differentiated methodic based on the typology of the nervous system.
Conclusion - an article can be useful for coaches who train in football and other sports.
The relevance of the topic is determined by the search for improvement of the training process for young players, which will increase the ability to kinesthetic differentiation of children and improve their results in football