bluuebunny/crossref_metadata_2025_split huggingface dataset:
Thymoquinone suppresses the proliferation of renal cell carcinoma cells via reactive oxygen species‐induced apoptosis and reduces cell stemness
Authors: Liou Yih‐Farng , Chen Pei‐Ni , Chu Shu‐Chen , Kao Shao‐Hsuan , Chang Yan‐Zin , Hsieh Yih‐Shou , Chang Horng‐Rong 
Published: July 2019

AbstractThymoquinone is a phytochemical compound isolated from Nigella sativa and has various biological effects, including anti‐inflammation, antioxidation, and anticancer. Here, we further investigated the anticancer effects and associated molecular mechanism of 2‐methyl‐5‐isopropyl‐1,4‐benzoquinone (thymoquinone) on human renal carcinoma cell lines 786‐O and 786‐O‐SI3 and transitional carcinoma cell line BFTC‐909. Results showed that thymoquinone significantly reduced cell viability, inhibited the colony formation of renal cancer cells, and induced cell apoptosis and mitochondrial membrane potential change in both cancer cells. In addition, thymoquinone also triggered the production of reactive oxygen species (ROS) and superoxide and the activation of apoptotic and autophagic cascade. ROS inhibition suppressed the caspase‐3 activation and restored the decreased cell viability of 786‐O‐SI3 in response to thymoquinone. Autophagy inhibition did not restore the cell viability of 786‐O‐SI3 suppressed by thymoquinone. Moreover, thymoquinone suppressed the cell sphere formation and the expression of aldehyde dehydrogenase, Nanog, Nestin, CD44, and Oct‐4 in 786‐O‐SI3 cells. The tumor‐bearing model showed that thymoquinone in vivo inhibited the growth of implanted 786‐O‐SI3 cell. All these findings indicate that thymoquinone inhibits the proliferation of 786‐O‐SI3 and BFTC‐909 cell possibly due to the induction of ROS/superoxide and the consequent apoptosis, suggesting that thymoquinone may be a potential anticancer supplement for genitourinary cancer.
Neue Musterweiterbildungsordnung Humangenetik
Authors: Tecklenburg Johanna 
Published: July 2019

Zusammenfassung
Nach langem Entstehungsprozess hat der Vorstand der Bundesärztekammer die Gesamtnovelle der neuen Musterweiterbildungsordnung (MWBO) am 15.11.2018 einstimmig beschlossen. Eine wesentliche Neuerung ist die Kompetenzbasierung der Weiterbildung – nicht mehr abgeleistete Zeiten sollen im Vordergrund stehen, sondern die tatsächlich erworbenen Inhalte, Kompetenzen und ärztliche Haltung. Weiteres Ziel ist die Flexibilisierung, Digitalisierung und eine größere Transparenz, auch durch die Einführung eines elektronischen Logbuchs zur kontinuierlichen Dokumentation der Weiterbildung. Für das Fachgebiet Humangenetik sieht die neue MWBO eine Stärkung der humangenetischen Patientenversorgung, eine deutlich dezidiertere Benennung der zu erwerbenden Kompetenzen, eine Anpassung an die aktuelle Entwicklung humangenetischer Labormethoden und eine Stärkung des klinisch-interdisziplinären Charakters vor. Die MWBO hat letztlich nur empfehlenden Charakter und muss durch die jeweiligen Landesärztekammern in eine verbindliche Weiterbildungsordnung umgesetzt werden. Eine konkrete Aussage, wann mit der bundesweiten Umsetzung durch die Landesärztekammern gerechnet werden kann, gibt es nicht, in einzelnen Kammern ist eine Umsetzung in der ersten Hälfte des Jahres 2020 geplant.
Traumatic brain injury and intimate partner violence: Addressing knowledge and service gaps among indigenous populations in Canada
Authors: Haag Halina (Lin) , Biscardi Melissa ,   Pauktuutit Inuit Women of Canada, Smith Noel (Natalia) , MacGregor Nneka , Colantonio Angela 
Published: July 2019

AbstractBackgroundTraumatic brain injury (TBI) is a serious consequence of intimate partner violence (IPV) that is often overlooked. In the case of Indigenous women in Canada the challenges are broad, multidimensional, and left almost entirely unexplored. Given the elevated rates of violence and injury experienced by women exposed to IPV and the increased levels of physical assault among Indigenous women in Canada, it is important to understand the unique experiences and service needs of these women. This study sought to identify barriers and facilitating factors for TBI-sensitive service provision for Indigenous women experiencing IPV.Method:As part of a larger national stakeholder consultation process to develop a TBI educational toolkit for IPV service providers, input from Indigenous stakeholders was specifically sought to allow for insights into unique challenges and strengths related to this population. Interviews and focus groups were conducted with IPV direct-service providers, support professionals, and advocates working with Canadian First Nations and Inuit women.Findings:Findings suggest that multiple intersections of marginalization, shame and stigma, and colonization, coupled with significant barriers to service provision in remote communities are such that solutions generated for urban-based settler populations are ineffective.Conclusions:Recommendations include a widespread educational campaign to raise awareness of the seriousness of TBI among Indigenous women exposed to IPV. Education is particularly important among healthcare and direct service providers, survivors and their families and communities, legal professionals and child protection agencies, and Indigenous and settler government bodies. Future research should focus on expanding our understanding of this complex issue and developing culturally sensitive, community-based supports.
Monte Carlo fusion
Authors: Dai Hongsheng , Pollock Murray , Roberts Gareth 
Published: July 2019

AbstractIn this paper we propose a new theory and methodology to tackle the problem of unifying Monte Carlo samples from distributed densities into a single Monte Carlo draw from the target density. This surprisingly challenging problem arises in many settings (for instance, expert elicitation, multiview learning, distributed ‘big data’ problems, etc.), but to date the framework and methodology proposed in this paper (Monte Carlo fusion) is the first general approach which avoids any form of approximation error in obtaining the unified inference. In this paper we focus on the key theoretical underpinnings of this new methodology, and simple (direct) Monte Carlo interpretations of the theory. There is considerable scope to tailor the theory introduced in this paper to particular application settings (such as the big data setting), construct efficient parallelised schemes, understand the approximation and computational efficiencies of other such unification paradigms, and explore new theoretical and methodological directions.
Relational exchangeability
Authors: Crane Harry , Dempsey Walter 
Published: July 2019

AbstractA relationally exchangeable structure is a random combinatorial structure whose law is invariant with respect to relabeling its relations, as opposed to its elements. Historically, exchangeable random set partitions have been the best known examples of relationally exchangeable structures, but the concept now arises more broadly when modeling interaction data in modern network analysis. Aside from exchangeable random partitions, instances of relational exchangeability include edge exchangeable random graphs and hypergraphs, path exchangeable processes, and a range of other network-like structures. We motivate the general theory of relational exchangeability, with special emphasis on the alternative perspective it provides and its benefits in certain applied probability problems. We then prove a de Finetti-type structure theorem for the general class of relationally exchangeable structures.
A unified stability theory for classical and monotone Markov chains
Authors: Kamihigashi Takashi , Stachurski John 
Published: July 2019

AbstractIn this paper we integrate two strands of the literature on stability of general state Markov chains: conventional, total-variation-based results and more recent order-theoretic results. First we introduce a complete metric over Borel probability measures based on ‘partial’ stochastic dominance. We then show that many conventional results framed in the setting of total variation distance have natural generalizations to the partially ordered setting when this metric is adopted.
Dinoflagellate cysts of the La Meseta Formation (middle to late Eocene), Antarctic Peninsula: implications for biostratigraphy, palaeoceanography and palaeoenvironment
Authors: Amenábar Cecilia R. , Montes Manuel , Nozal Francisco , Santillana Sergio 
Published: July 2019

AbstractDinoflagellate cyst assemblages recovered from the La Meseta Formation cropping out in Seymour Island, Antarctic Peninsula, are studied herein and their distribution is compared with the biostratigraphic scheme available for the Palaeogene of the Southern Ocean and other high-latitude regions. In this way, the La Meseta Formation is dated as middle Lutetian to Priabonian (46.2–36 Ma), which differs from the age provided by other fossils, isotopes and also with the magnetostratigraphic scheme recently performed for the unit. The dinoflagellate cyst data support the proposal of ocean circulation patterns on the South American Shelf prior to the opening of Drake Passage. Assemblages from the La Meseta Formation contain Antarctic-endemic taxa which are also dominant in several circum-Antarctic sites, located south of 45° S. Their distribution reflects an ocean-circulation scheme with wide clockwise gyres surrounding Antarctica that were disrupted as a consequence of the deepening and definitive apertures of the Tasmanian Gateway and Drake Passage towards the Eocene/Oligocene transition. The palaeoenvironmental inference based on the S/D ratio (sporomorphs versus dinoflagellate cysts) and the P/G ratio (peridinioid versus gonyaulacoid dinoflagellate cysts) suggests an overall trend through the section from marine-dominated assemblages with poorly productive waters in the lower part of the section to more terrestrially dominated assemblages with increasing productivity in the upper part of the unit, reflecting a shallowing trend to the top.
A Beveridge Plan for India? Social Insurance and the Making of the “Formal Sector”
Authors: Ahuja Ravi 
Published: July 2019

AbstractThe article explores the history of the Employees’ State Insurance Act of 1948 (ESI), a law enacted in the first year of Indian independence. Global trends in social policy had influenced debates on a social insurance for Indian workers since the 1920s. Transformations of Indian industry, World War II, the post-war crisis, and the emerging economic policy of the postcolonial State then created conditions for legislation. Just as the international welfare discourse, Indian contributions included, converged on social welfare as a universal citizen right, the regulatory content of the health insurance scheme devised for India diverged from this normative consensus: the ESI Act remained strictly employment-based, contributed to an emerging structure of graded entitlements, and to the hardening of boundaries between what would later be called “formal” and “informal” labour. Simultaneously, it also generated horizons of expectation that continue to inform labour struggles.
Transdiagnostic validity of the MATRICS Consensus Cognitive Battery across the autism-schizophrenia spectrum
Authors: Kuo Susan S. , Wojtalik Jessica A. , Mesholam-Gately Raquelle I. , Keshavan Matcheri S. , Eack Shaun M. 
Published: July 2019

AbstractBackgroundAutism Spectrum Disorder (ASD) and schizophrenia are neurodevelopmental disorders which share substantial overlap in cognitive deficits during adulthood. However, treatment evaluation in ASD and treatment comparisons across ASD and schizophrenia are limited by a dearth of empirical work establishing the validity of a standard cognitive battery across ASD and schizophrenia. Promisingly, the MATRICS Consensus Cognitive Battery (MCCB) has been validated in schizophrenia and encompasses cognitive domains that are impacted in ASD. Thus, this study aimed to establish MCCB's generalizability from schizophrenia to ASD.MethodsCommunity-residing adults with schizophrenia (N = 100) and ASD (N = 113) underwent MCCB assessment. Using multigroup confirmatory factor analysis, MCCB's transdiagnostic validity was evaluated by examining whether schizophrenia and ASD demonstrate the same configuration, magnitude, and directionality of relationships within and among measures and their underlying cognitive domains.ResultsAcross schizophrenia and ASD, the same subsets of MCCB measures inform three cognitive domains: processing speed, attention/working memory, and learning. Except for group means in category fluency, continuous performance, and spatial span, both groups show vastly comparable factor structures and characteristics.ConclusionsTo our knowledge, this study is the first to establish the validity of a standard cognitive battery in adults with ASD and furthermore the first to establish a cognitive battery's comparability across ASD and schizophrenia. Cognitive domain scores can be compared across new samples using weighted sums of MCCB scores resulting from this study. These findings highlight MCCB's applicability to ASD and support its utility for standardizing treatment evaluation of cognitive outcomes across the autism-schizophrenia spectrum.
Who will benefit from computerized cognitive remediation therapy? Evidence from a multisite randomized controlled study in schizophrenia
Authors: Tan Shuping , Zhu Xiaolin , Fan Hongzhen , Tan Yunlong , Yang Fude , Wang Zhiren , Zhao Yanli , Fan Fengmei , Guo Junhua , Li Zhanjiang , Quan Wenxiang , Wang Xiangqun , Reeder Clare , Zhou Dongfeng , Zou Yizhuang , Wykes Til 
Published: July 2019

AbstractBackgroundComputerized cognitive remediation therapy (CCRT) is generally effective for the cognitive deficits of schizophrenia. However, there is much uncertainty about what factors mediate or moderate effectiveness and are therefore important to personalize treatment and boost its effects.MethodIn total, 311 Chinese inpatients with Diagnostic and Statistical Manual of Mental Disorders-IV schizophrenia were randomized to receive CCRT or Active control for 12 weeks with four to five sessions per week. All participants were assessed at baseline, post-treatment and 3-month follow-up. The outcomes were cognition, clinical symptoms and functional outcomes.ResultsThere was a significant benefit in the MATRICS Consensus Cognitive Battery (MCCB) total score for CCRT (F1,258 = 5.62; p = 0.02; effect size was 0.27, 95% confidence interval 0.04–0.49). There were no specific moderators of CCRT improvements. However, across both groups, Wisconsin Card Sort Test improvement mediated a positive effect on functional capacity and Digit Span benefit mediated decreases in positive symptoms. In exploratory analyses younger and older participants showed cognitive improvements but on different tests (younger on Symbol Coding Test, while older on the Spatial Span Test). Only the older age group showed MSCEIT benefits at post-treatment. In addition, cognition at baseline negatively correlated with cognitive improvement and those whose MCCB baseline total score was around 31 seem to derive the most benefit.ConclusionsCCRT can improve the cognitive function of patients with schizophrenia. Changes in cognitive outcomes also contributed to improvements in functional outcomes either directly or solely in the context of CCRT. Age and the basic cognitive level of the participants seem to affect the cognitive benefits from CCRT.
Minimum Base Disturbance Control of Free-Floating Space Robot during Visual Servoing Pre-capturing Process
Authors: Zhao Xiaoyu , Xie Zongwu , Yang Haitao , Liu Jiarui 
Published: July 2019

SUMMARYDuring visual servoing space activities, the attitude of free-floating space robot may be disturbed due to dynamics coupling between the satellite base and the manipulator. And the disturbance may cause communication interruption between space robot and control center on earth. However, it often happens that the redundancy of manipulator is not enough to fully eliminate this disturbance. In this paper, a method named off-line optimizing visual servoing algorithm is innovatively proposed to minimize the base disturbance during the visual servoing process where the degrees-of-freedom of the manipulator is not enough for a zero-reaction control. Based on the characteristic of visual servoing process and the robot system modeling, the optimal control method is applied to achieve the optimization, and a pose planning method is presented to achieve a second-order continuity of quaternion getting rid of the interruption caused by ambiguity. Then simulations are carried out to verify the method, and the results show that the robot is controlled with optimized results during visual servoing process and the joint trajectories are smooth.
Learning music theory en passant: a study in an internationally recognised South African University student choir
Authors: Barrett Michael , Page-Shipp Roy , van Niekerk Caroline , Ferreira Johan 
Published: July 2019

AbstractWhile mastery of aspects of music theory is relevant to rapid learning and understanding of a new choral part, many choirs comprise members with no formal education in music theory. Also, the language of music theory is not intuitive, with many terms having meanings different from those in common use, which can present obstacles for mature learners. The authors hypothesised that students joining an internationally recognised university choir might master aspects of music theory as a by-product of rehearsals. This was tested by having new admissions to such a choir complete a music theory test at the commencement and at the end of a year. The test evaluated the ability to name and write intervals and name notes and the duration of notes. Overall results did not reject the hypothesis. Subjects with no formal music training also showed most, and statistically significant, improvement in the questions related to intervals, which are arguably the most useful skills for choristers who do not sight-read. This appears to be a new finding: the literature shows occasional references to music theory skills, but their acquisition in a learning-by-doing style is not reported. Some insights into ways of enhancing choral performance are a by-product of the principal focus of the study.
Explaining diversity patterns in dark waters – a study of aquatic caves in Yucatán, Mexico
Authors: Hendus Barbara , Medina-González Róger , Sélem-Salas Celia , Vanschoenwinkel Bram 
Published: July 2019

AbstractIn the tropics, limestone caves in karstic areas are known for their unique biodiversity. However, many caves remain unstudied and little is known about underlying gradients that determine diversity and biomass in aquatic microhabitats. Here, we sampled zooplankton and benthos in a set of 12 aquatic caves, locally called closed cenotes in Yucatán, Mexico. Our aim was to explain diversity patterns and differences in biomass with particular attention for correlations between bat colony characteristics and other biota. Compared with caves that support photosynthesis, diversity was low with an average of four planktonic and two benthic species in these dark caves. Undetectable phosphorus concentrations in the water suggest this nutrient is limiting. Several associations hint at a potential link between bat abundance and functional guild composition, water quality and aquatic biota. As such, more bats were linked to higher nitrate concentrations. Yet this was not translated to higher invertebrate biomass, probably since phosphorus is limiting. Overall, the trends found in this survey suggest that bats could be important as fertilizers of the caves although mechanistic links that mediate the flux of nutrients need to be confirmed experimentally.
Syndemic effects of HIV risk behaviours: results from the NHANES study
Authors: Smith L. , Cao C. , Zong X. , McDermott D. T. , Stefanac S. , Haider S. , Jackson S. E. , Veronese N. , López-Sánchez G. F. , Koyanagi A. , Yang L. , Grabovac I. 
Published: July 2019

Abstract
The aim of the present study is to use the syndemic framework to investigate the risk of contracting HIV in the US population. Cross-sectional analyses are from The National Health and Nutrition Examination Survey. We extracted and aggregated data on HIV antibody test, socio-demographic characteristics, alcohol use, drug use, depression, sexual behaviours and sexually transmitted diseases from cycle 2009–2010 to 2015–2016. We carried out weighted regression among young adults (20–39 years) and adults (40–59 years) separately. In total, 5230 men and 5794 women aged 20–59 years were included in the present analyses. In total, 0.8% men and 0.2% women were tested HIV-positive. Each increasing HIV risk behaviour was associated with elevated odds of being tested HIV-positive (1.15, 95% CI 1.15–1.15) among young adults and adults (1.61, 95% CI 1.61–1.61). Multi-faceted, community-based interventions are urgently required to reduce the incidence of HIV in the USA.
Precision QALYs, Precisely Unjust
Authors: FLECK LEONARD M. 
Published: July 2019

Abstract:Warwick Heale has recently defended the notion of individualized and personalized Quality-Adjusted Life Years (QALYs) in connection with health care resource allocation decisions. Ordinarily, QALYs are used to make allocation decisions at the population level. If a health care intervention costs £100,000 and generally yields only two years of survival, the cost per QALY gained will be £50,000, far in excess of the £30,000 limit per QALY judged an acceptable use of resources within the National Health Service in the United Kingdom. However, if we know with medical certainty that a patient will gain four extra years of life from that intervention, the cost per QALY will be £25,000. Heale argues fairness and social utility require such a patient to receive that treatment, even though all others in the cohort of that patient might be denied that treatment (and lose two years of potential life). Likewise, Heale argues that personal commitments of an individual (religious or otherwise), that determine how they value a life-year with some medical intervention, ought to be used to determine the value of a QALY for them. I argue that if Heale’s proposals were put into practice, the result would often be greater injustice. In brief, requirements for the just allocation of health care resources are more complex than pure cost-effectiveness analysis would allow.
Urban Bioethics: A Call for the Prestige
Authors: JOHNSON NIA , WAHLERT LANCE 
Published: July 2019

Abstract:Many teaching hospitals in the United States were founded on philanthropic principles and aimed to aid the urban poor and underserved. However, as times have changed, there has been a divide created between the urban poor and teaching hospitals. There is a plethora of reasons why this is the case. This paper will specifically focus on the histories of ten hospitals and medical schools and the effect that white flight, segregation, elitism, and marginalization had on healthcare institutions all over the United States. It will call for a reexamination of the values of Ivy League and Ivy Plus teaching hospitals and medical schools and for them to take an intentional look into their communities.