bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mesenchymal Stem/ Stromal Cells metabolomic and bioactive factors profiles: a comparative analysis on the Umbilical Cord and Dental Pulp derived Stem/ Stromal Cells secretome
Authors: Caseiro AR , Pedrosa SS , Ivanova G , Branquinho MV , Almeida A , Faria F , Amorim I , Pereira T , Maurício AC 
Published: August 2019

AbstractMesenchymal Stem/ Stromal Cells assume a supporting role to the intrinsic mechanisms of tissue regeneration, a feature mostly assigned to the contents of their secretome. A comparative study on the metabolomic and bioactive molecules/factors content of the secretome of Mesenchymal Stem/ Stromal Cells derived from two expanding sources: the umbilical cord stroma and the dental pulp is presented and discussed. The metabolic profile (Nuclear Magnetic Resonance Spectroscopy) evidenced some differences in the metabolite dynamics through the conditioning period, particularly on the glucose metabolism. Despite, overall similar profiles are suggested. More prominent differences are highlighted for the bioactive factors (Multiplexing Laser Bear Analysis), in which Follistatin, Growth Regulates Protein, Hepatocyte Growth Factor, Interleukin-8 and Monocyte Chemotactic Protein-1 dominate in Umbilical Cord Mesenchymal Stem/ Stromal Cells secretion, while in Dental Pulp Stem/ Stromal Cells the Vascular Endothelial Growth Factor-A and Follistatin are more evident. The distinct secretory cocktail did not result in significantly different effects on endothelial cell populations dynamics including proliferation, migration, tube formation capacity and in vivo angiogenesis, or in chemotaxis for both Mesenchymal Stem/ Stromal Cells populations.
Computational modelling of the long-term effects of brain stimulation on the local and global structural connectivity of epileptic patients
Authors: Giannakakis Emmanouil , Hutchings Frances , Papasavvas Christoforos A. , Han Cheol E. , Weber Bernd , Zhang Chencheng , Kaiser Marcus 
Published: August 2019

AbstractIn patients with drug resistant focal epilepsy, targeted weak stimulation of the affected brain regions has been proposed as an alternative to surgery. However, the effectiveness of stimulation as a treatment presents great variation from patient to patient. In this study, brain activity is simulated for a period of one day using a network of Wilson-Cowan oscillators coupled according to diffusion imaging based structural connectivity. We use this computational model to examine the potential long-term effects of stimulation on brain connectivity. Our findings indicate that the overall simulated effect of stimulation is heavily dependent on the excitability of the stimulated regions. Additionally, stimulation seems to lead to long-term effects in the connectivity of secondary (non-stimulated) regions in epileptic patients. These effects are correlated with a worse surgery outcome in some patients, which suggests that long-term simulations could be used as a tool to determine suitability for surgery/stimulation.
Breeding of a high-yield strain for commercial cultivation by crossing Pholiota adiposa and P. limonella
Authors: Rong Chengbo , Song Shuang , Yang Li , Zhang Jiachan , Niu Yurong , Pan Xuejiao , Song Qinggang , Liu Yu , Wang Shouxian 
Published: August 2019

AbstractPholiota adiposa is an edible mushroom with excellent nutritional and medicinal properties. However, fruiting body yields are low, and the commercial cultivation potential of this fungus is limited. In the present study, 279 crossbred strains were obtained by mono-mono crossing of monokaryotic strains derived from P. adiposa HS5 and P. limonella HS4. Ligninolytic enzymes and mycelial growth rate were used as markers to screen the crossbred strains, and 18 were selected for further analysis. Crossbred strain A10B4 displayed the highest yield, i.e., 165.91 ± 12.56 g per bag, which was 31.34 g and 74.48 g more than that of strains HS5 and HS4, respectively. The mycelial colonization time of A10B4 was 25.18 ± 1.33 days, which was 5.64 days shorter than that of HS5. A10B4 was characterized by inter-simple sequence repeat molecular markers and antagonism tests. Differences in PCR products from parental and crossbred strains were observed. Therefore, the newly developed hybrid strain A10B4, named P. adiposa-limonella HS54 and having a high yield and desirable traits, might be suitable for commercial cultivation.
A Tukey’s g-and-h distribution based approach with PSO for degradation reliability modeling
Authors: Zhang Jinbao , Zhao Yongqiang , Liu Ming , Kong Lingxian 
Published: August 2019

PurposeA generalized distribution with wide range of skewness and elongation will be suitable for the data mining and compatible for the misspecification of the distribution. Hence, the purpose of this paper is to present a distribution-based approach for estimating degradation reliability considering these conditions.Design/methodology/approachTukey’s g-and-h distribution with the quantile expression is introduced to fit the degradation paths of the population over time. The Newton–Raphson algorithm is used to approximately evaluate the reliability. Simulation verification for parameter estimation with particle swarm optimization (PSO) is carried out. The effectiveness and validity of the proposed approach for degradation reliability is verified by the two-stage verification and the comparison with others’ work.FindingsSimulation studies have proved the effectiveness of PSO in the parameter estimation. Two degradation datasets of GaAs laser devices and crack growth are performed by the proposed approach. The results show that it can well match the initial failure time and be more compatible than the normal distribution and the Weibull distribution.Originality/valueTukey’s g-and-h distribution is first proposed to investigate the influence of the tail and the skewness on the degradation reliability. In addition, the parameters of the Tukey’s g-and-h distribution is estimated by PSO with root-mean-square error as the object function.
Cross-border M&As: integration practices from emerging economies
Authors: Jain Samta , Kashiramka Smita , Jain P.K. 
Published: August 2019

PurposeThe purpose of the study is to gain insights into the post-acquisition integration practices of Indian multinational companies involved in cross-border acquisitions.Design/methodology/approachThe study is based on the primary data from a sample of Indian companies engaged in cross-border acquisitions. A survey (based on a structured questionnaire) method has been used to collect the relevant data.FindingsMajority of the sample companies have successfully managed the post-acquisition phase and realized the anticipated synergies. These companies recognize the importance of cultural integration, people/HR integration and formal communication channel during the post-acquisition phase. Despite the integration strategy being profoundly influenced by cultural differences between two companies, the emphasis on these cultural differences especially during the due-diligence stage is lacking. These aspects have not been examined adequately during the due-diligence phase.Practical implicationsBased on the findings, a model of cross-border acquisition and integration process (AIP) in the context of emerging economies has been proposed; the model is expected to be applicable across all industries and organizations, especially in emerging economies. The proposed model should essentially help senior and middle managers to develop successful integration strategies. Moreover, the study holds immense potential for practitioners and academicians by providing them with a new thought on executing successful acquisitions.Originality/valueTo the best of the authors’ knowledge, no study has examined the post-acquisition integration approach in emerging economies. Moreover, rarely has any AIP model applicable across several organizations of all sizes and types from emerging economies been suggested in the literature. The suggested AIP model is the unique proposition of the paper.
An update on customer value: state of the art, revised typology, and research agenda
Authors: Leroi-Werelds Sara 
Published: August 2019

Purpose
The context of marketing and service research is rapidly changing as a result of advances in academic research and business practice. This has implications for our understanding of customer value. The purpose of this paper is to provide an update on customer value given today’s context (including recent advances such as technologies, human contact, collaborative consumption, service ecosystems and transformative service research); to revise Holbrook’s value typology; and to propose a research agenda.

Design/methodology/approach
This paper uses a conceptual approach that is rooted in the service and marketing literature.

Findings
The contribution of this paper is threefold. First, this paper presents an evolved view on customer value which accounts for recent advances in academic research and business practice. Second, this paper updates Holbrook’s value typology by revising existing value types as well as identifying additional value types; and offers guidelines for measuring and modeling customer value. Third, this paper proposes a research agenda to guide and stimulate future value research.

Originality/value
This paper provides an update on customer value, which is one of the most fundamental concepts in service and marketing research. This updated perspective has been approved and applauded by Morris B. Holbrook, one of the founding fathers of value research.
Utilising community engagement approaches to influence public mental health policy in a rural setting
Authors: Thirlwall Claire , Whitelaw Sandy 
Published: August 2019

Purpose
Drawing on the notion of “mental health policy participation”, the purpose of this paper is to describe and reflect on a regional case study of a community engagement approach that explored community perspectives on mental health and the factors that influence it. It established three expectations, that: the development of the Dumfries and Galloway Public Mental Health Strategy is informed by project outputs; services and innovations are based on what people want; active involvement of local people in decision making around mental health services and strategy is achieved.

Design/methodology/approach
A “participatory appraisal” approach was used to engage with communities. A three-day “Training of Trainers” exercise was undertaken. These individuals then accessed a number of community groups. Data collection was based on five key questions. A total of 443 were engaged in the process. Insights were reviewed by 20 stakeholders from a range of services to identify key actions. This led to the development of the mental health forum and, in turn, a Public Mental Health Strategy for Dumfries and Galloway. Community members were further included in processes through feedback mechanisms.

Findings
Factors of resilience, support of families and friends, social inclusion, access to social and leisure opportunities were most important. This was followed by structural issues like fear of judgement, lack of transport, discrimination and financial support. Finally, individual factors (sleep, meaningful hobbies and health) were highlighted.

Originality/value
This approach sought to go beyond a traditional focus to explore broader community perspectives on mental health and the factors that influence it.
Comparison of the change in interpretative stances of lifelog photos versus manually captured photos over time
Authors: Lee Ahreum , Ryu Hokyoung 
Published: August 2019

Purpose
The purpose of this paper is to explore how people differently create meaning from photos taken by either a lifelogging camera (LC) (i.e. automatic capture) or a mobile phone camera (MC) (i.e. manual capture). Moreover, the paper investigates the different changes in the interpretative stance of lifelog photos and manually captured photos over time to figure out how the LC application could support the users’ iconological interpretation of their past.

Design/methodology/approach
A 200-day longitudinal study was conducted with two different user groups that took and reviewed photos taken by either a LC or a MC. The study was structured in two phases: a photo collection phase, which lasted for five days (Day 1‒Day 5), and a three-part semi-structured interview phase, which was conducted on Days 8, 50 and 200.

Findings
Results revealed that the interpretative stance of the LC group changed greatly compared to the MC group that kept a relatively consistent interpretative stance over time. A significant difference between the two groups was revealed on Day 200 when the lifelog photos provoked a more iconological and less pre-iconographical interpretative stance. This stance allowed the viewers of lifelog photos to systemically interpret the photos and look back upon their past with different viewpoints that were not recognized before.

Originality/value
This paper contributes to further understand the dynamic change in interpretative stance of lifelog photos compared to manually captured photos through a longitudinal study. The results of this study can support the design guidelines for a LC application that could give opportunities for users to create rich interpretations from lifelog photos.
Optimisation of screen printing process for functional printing
Authors: Ali Muhammad , Lin Long , Faisal Saira , Sahito Iftikhar Ali , Ali Syed Imran 
Published: August 2019

PurposeThe purpose of this study is to explain the effects of screen printing parameters on the quantity of ink deposited and the print quality in the context of printing of functional inks. Both these aspects of printing are crucial in the case of conventional and functional printing. This is because, in the case of conventional printing, the quantity of ink deposit affects the color strength while in the case of functional printing, it directly affects the resulting functionality of the ink layer.Design/methodology/approachIn this work, an automatic lab-scale screen printer was used to print functional inks on a paper board substrate. The printing parameters, i.e. printing pressure and squeegee angle were altered and the resulting effects on the quantity of ink that was deposited were recorded. The quantity of ink deposit was related to its surface resistivity. In addition, the quality of the print was also assessed by examining the design registration quality.FindingsThe authors found that altering the squeegee angle has a significant effect on the properties of the resulting ink deposit. More importantly, the authors found that the deflection in the rubber blade squeegee was greatly dependent on the initial angle of the squeegee at the start of the printing stroke. For each set value of the squeegee angle that was considered, the actual angle during printing was recorded and used in the analysis. A printing pressure of three bars and squeegee angle of 20° resulted in the maximum weight of ink deposit with a correspondingly lowest surface resistivity.Practical implicationsThis study is envisaged to have considerable practical implications in the rapidly growing field of functional printing of flexible substrates including, but not limited to, textiles. This is because, the study provides an insight into the effects of printing parameters on the characteristics of a functional ink deposit.Originality/valueScreen printing of flexible substrates is a well-developed and arguably the most widely used printing technique, particularly for textiles. Numerous studies report on the analysis of various aspects of screen printing. However, to the best of the knowledge, the effects of printing parameters on the characteristics of functional inks, such as electrically conductive inks, have not been studied in this manner.
Clinical characteristics and treatment of 52 cases of phakomatosis pigmentovascularis
Authors: Shin Hyoseung , Kim Young Gull , Kim Ye Eun , Park Hyunsun 
Published: August 2019

AbstractPhakomatosis pigmentovascularis is a rare syndrome characterized by widespread capillary malformation and pigmented nevus. The objective of this study was to evaluate its characteristics and treatment. Fifty‐two patients presenting between 2003 and 2017 were retrospectively reviewed. Type IIa (port‐wine stain and dermal melanocytosis with oculocutaneous involvement) was most common. Systemic involvement was observed in 17.3% and it was not significantly correlated to extent of capillary malformation or pigmented nevus. However, systemic involvement was significantly frequent in patients with nevus of Ota and in patients with pigmented nevus located on the head and neck (P = 0.004 and 0.035, respectively). Capillary malformation was almost cleared in 28.6% of patients using pulsed dye laser, whereas pigmented nevus was almost cleared in 23.7% and completely cleared in 42.1% of patients using Q‐switched neodymium:yttrium–aluminum–garnet laser. Treatment outcome score showed significant inverse correlation with the extent of port‐wine stain or pigmented nevus (P = 0.047, ρ = −0.308 and P = 0.011, ρ = −0.410, respectively). Pigmented nevus demonstrated better treatment response to lasers than did capillary malformation. Smaller lesions tended to show better treatment outcomes for both capillary malformation and pigmented nevus.
Increased risk of cardiovascular comorbidities in hidradenitis suppurativa: A nationwide, population‐based, cohort study in Taiwan
Authors: Hung Chih‐Tsung , Chiang Chien‐Ping , Chung Chi‐Hsiang , Tsao Chang‐Huei , Chien Wu‐Chien , Wang Wei‐Ming 
Published: August 2019

AbstractHidradenitis suppurativa (HS) has been reported to be associated with metabolic syndrome and coronary artery disease (CAD). Nevertheless, a nationwide study of this relationship in the Asian population has not been conducted. The aim of the present study was to clarify the cardiovascular disease risk factors, and the occurrence of CAD and cerebral infarction among patients with HS by using a nationwide database in Taiwan. We obtained data from the National Health Insurance Research Database of Taiwan. After adjusting for confounding factors, we used Cox proportional hazards analysis to reveal the risk of incident hypertension (HTN), diabetes mellitus (DM), dyslipidemia, CAD and cerebral infarction in HS patients. We identified 478 patients with newly diagnosed HS and 1912 patients in the control cohort during the 10‐year follow‐up period. Compared with the controls, HS patients had a higher risk of dyslipidemia (adjusted hazard ratio [aHR], 3.858; 95% confidence interval [CI], 2.785–5.346; P < 0.001), HTN (aHR, 1.910; 95% CI, 1.463–2.493; P < 0.001), DM (aHR, 1.709; 95% CI, 1.127–2.591; P = 0.012). Regarding comorbidities, our results also revealed a higher risk of CAD in HS patients (aHR, 2.722; 95% CI, 1.628–4.553; P < 0.001), but not cerebral infarction (aHR, 0.514; 95% CI, 0.119–2.231; P = 0.375). Our results indicate that there is a higher risk of dyslipidemia, HTN, DM and CAD in HS patients.
Diagnoses, damned diagnoses and statistics: Dealing with disparate diagnostic coding systems within the New South Wales Emergency Department Data Collection
Authors: Dinh Michael M , Berendsen Russell Saartje , Bein Kendall J 
Published: August 2019

AbstractObjectivesThe aims of the present study were to describe the distribution of Systematised Nomenclature of Medicine – Clinical Terms (SNOMED‐CT) codes used in the current New South Wales Emergency Department Data Collection (NSW EDDC) and classify duplicate and redundant terms into clinically meaningful sub‐groups for future analyses.MethodsThis was an analysis of ED diagnosis codes using a large state‐wide administrative ED dataset between 2015 and 2018.ResultsA total of 7.4 million (77%) of ED episode diagnoses were coded with SNOMED‐CT. Of those coded with SNOMED‐CT, 12 152 unique codes were identified. Around 1000 of the most frequently used codes accounted for 90% of the presentations coded with SNOMED‐CT and 5000 codes accounted for 99.8% of these. Around 7000 codes were deemed to be redundant, and duplication in terms exists across all sub‐groups.ConclusionThe use of SNOMED‐CT in the NSW EDDC has resulted in substantial use of non‐specific, duplicate and redundant codes, limiting the capacity of the NSW EDDC to be used for effective data analysis.
Senescence‐associated tissue microenvironment promotes colon cancer formation through the secretory factor GDF15
Authors: Guo Yuna , Ayers Jessica L. , Carter Kelly T. , Wang Ting , Maden Sean K. , Edmond Darwin , Newcomb P Polly , Li Christopher , Ulrich Cornelia , Yu Ming , Grady William M. 
Published: August 2019

AbstractThe risk of colorectal cancer (CRC) varies between people, and the cellular mechanisms mediating the differences in risk are largely unknown. Senescence has been implicated as a causative cellular mechanism for many diseases, including cancer, and may affect the risk for CRC. Senescent fibroblasts that accumulate in tissues secondary to aging and oxidative stress have been shown to promote cancer formation via a senescence‐associated secretory phenotype (SASP). In this study, we assessed the role of senescence and the SASP in CRC formation. Using primary human colon tissue, we found an accumulation of senescent fibroblasts in normal tissues from individuals with advanced adenomas or carcinomas in comparison with individuals with no polyps or CRC. In in vitro and ex vivo model systems, we induced senescence using oxidative stress in colon fibroblasts and demonstrated that the senescent fibroblasts secrete GDF15 as an essential SASP factor that promotes cell proliferation, migration, and invasion in colon adenoma and CRC cell lines as well as primary colon organoids via the MAPK and PI3K signaling pathways. In addition, we observed increased mRNA expression of GDF15 in primary normal colon tissue from people at increased risk for CRC in comparison with average risk individuals. These findings implicate the importance of a senescence‐associated tissue microenvironment and the secretory factor GDF15 in promoting CRC formation.
Transforming the Classic Political Forest: Contentious Territories in Java
Authors: Lukas Martin C. , Peluso Nancy Lee 
Published: August 2019

AbstractJava’s extensive political forests and their contentious social relations have been profoundly transformed since the turn of the 21st century. This paper analyses new forms of forest land use, control, and revenue distribution, shaping and shaped by political‐economic changes and neoliberal‐era reforms. Villagers’ expanded uses, access to, and control of the forest understory under the violently thinned out canopies of the main tree species has generated newly spatialised forest politics, with new institutions and forest labour practices. The changes in land, species, and labour controls, and in villagers’ access to forest products and revenues define this historical transformation in the constitution of Java’s classic political forest. Contentious co‐production has resulted in fragmented territories and a momentary (at least) weakening of state controls within the old imperial political forest.