bluuebunny/crossref_metadata_2025_split huggingface dataset:
An Updated Review of Nano Techniques for Enhancing the Bioavailability and Therapeutic Efficacy of Poly Phenolic Bioactive Compounds
Authors: Karuppaiah Arjunan , Annamalai Giridharan , Dhasaiyan Mohankumar , Manikandan Sangeethkumar , Ani Jose Preethy , Rahman Habibur 
Published: December 2024

Introduction:
Based on the scientific evaluation from the literature survey, polyphenolic
compounds have numerous health benefits but limitations such as poor bioavailability, making
it difficult for the formulator. Polyphenolic compounds face major challenges such as poor solubility,
stability, and lesser absorption in the body. It is the major concern towards the bioactives for
formulating it into suitable delivery and also for specific activity.

Objective:
The main aim of this article is to describe the developments in nanoformulation techniques
designed to enhance the bioavailability of polyphenols and other bioactives.

Methods:
The PubMed literature survey with the key term “enhancing the bioavailability of poly
phenolic bioactive compounds brought around 38 articles for the year 2008 to 2024. The term
“nanoformulations for Poly phenols” tend to give the efficient methodologies and different nanoformulation
techniques for formulating the bioactives. Nanoformulations are said to have advancements
like nanoscale range in size, and tailored structure which give solutions to overcome the
challenges and improve the delivery of bioactives. It serves as an innovative solution and has an
impact on the improvement of polyphenols. The evaluation role includes the modulation of pharmacokinetic,
pharmacodynamic, and enhancement of therapeutic efficacy by applying the nanoformulation
methods.

Results:
This review mainly highlights the lipid-based nanocarriers such as SLN, NLC, Liposomes,
Niosomes, Ethosomes, Transferosomes, and Nanoemulsion and their different methods.
The key information about the current trends, benefits, and future directions.

Conclusion:
In summary, this article concludes with the advancement made using nanoformulation
techniques and effective therapeutic strategies in the field of nano nutraceuticals.
Investigating the Relationship Between Postpartum Depression, Antenatal Depression, Corona Disease Anxiety, and Personality Traits During the
COVID-19 Pandemic
Authors: Nejad Hanieh Soltani , Mohtasham Fatemeh , Ramezanzadeh Mahjoubeh , Arashlouei Azam Zare , Ahmadi Atefeh , Dadvar Adeleh , Iranmanesh Saleheh , Mirmahmoodi Motahare 
Published: December 2024

Background and Aim:
Postpartum depression has a profound impact, both physically and
psychologically, on both the mother and her newborn. With a focus on the prevalent psychological
complications following the onset of this condition, this study aimed to explore the correlation between
antenatal depression and Corona disease anxiety, personality traits, and postpartum depression
during the COVID-19 pandemic.

Materials and Methods:
This cross-sectional descriptive-analytical study investigated women receiving
care at health centers affiliated with Kerman University of Medical Sciences during the last
month of their pregnancy and the postpartum period in 2022. Following the acquisition of informed
consent, participants were assessed using various measures, including demographic and obstetric
information, the Edinburgh Postnatal Depression Scale, the Corona Disease Anxiety Scale (CDAS),
and the NEO Personality Inventory-Revised during their third trimester of pregnancy. The same
group of participants completed the Edinburgh Depression Scale and the Corona Disease Anxiety
Scale (CDAS) 4-6 weeks after childbirth.

Results:
There was a significant correlation between family income, unwanted pregnancy as perceived
by both the mother and father, and antenatal depression. Additionally, marital satisfaction
played a significant role in postpartum depression. Furthermore, antenatal depression was significantly
associated with neuroticism, agreeableness, and physical symptoms related to Corona disease
anxiety. Personality traits, with the exception of extroversion and conscientiousness, and various
domains of Corona disease anxiety, excluding psychological symptoms, were also significantly associated
with postpartum depression.

Conclusion:
During pandemics or epidemics, such as the COVID-19 outbreak, experiencing mental
distress during pregnancy can contribute to mental health issues during the postpartum period. This
risk is particularly true in individuals with unique personality traits, emphasizing the need for increased
focus on mental health within prenatal care during these crises.
Investigating the Relationship Between the Levels of Hematological and Biochemical Parameters of COVID-19 Patients with the Length of
Hospitalization
Authors: Hedayati-Moghadam Mahdia , Sharifi Elham , Afsharpour Nazanin , Akbari Nastaran Ali , Shokoufamanesh Ayuob , Saghari Sam , Raesi Rasoul , Hushmandi Kiavash , Daneshi Salman 
Published: December 2024

Background:
Identifying and treating patients with COVID-19 requires the use of quick
and precise laboratory diagnostic techniques that assess the patient's health and identify the illness.

Aim:
This study was conducted to determine the relationship between hematological and biochemical
parameters and length of hospitalization in patients with COVID-19.

Methods:
This is a cross-sectional study of a descriptive-analytical type, which was conducted by
census method on 360 medical records of patients with COVID-19 in Imam Khomeini Hospital in
Jiroft in 2022. Data were analyzed using descriptive and inferential statistics tests.

Results:
The average number of days of hospitalization in the present study was 4 days. The rate of
COVID-19 was higher in men than in women. The most common underlying diseases in the patients
were heart, pulmonary, and diabetes. Among the biochemical parameters, only lactate dehydrogenase
(LDH), blood urea nitrogen (BUN), aspartate aminotransferase (AST), alanine transaminase
(ALT), platelet (PLT), and erythrocyte sedimentation rate (ESR) parameters had a statistically significant
relationship with the total length of hospitalization (P-value<0.001). LDH, AST, ALT, creatinine
(Cr), creatine phosphokinase (CPK), blood sugar (BS), total bilirubin, and direct bilirubin parameters
were higher than normal in hospitalized patients.

Conclusion:
The results showed that there is a relationship between LDH, BUN, AST, ALT, PLT,
and ESR parameters and the length of hospitalization of patients. The levels of LDH, AST, ALT, Cr,
CPK, BS, total bilirubin, and direct bilirubin parameters in patients were higher than normal.
Aero-space and Astro-cosmic Microbial Studies: A Vulgar Epithet Yet an Unattended Potential Nursing/Distribution Hub of Pathogenic Strains
Authors: Igere Bright E. , Ekundayo Temitope C. , Beshiru Abeni T. , Uwhuba Kate E. , Gbona Kesiena C. , Ijabadeniyi Oluwatosin A. 
Published: December 2024

Introduction:
The ubiquity of microorganisms has in recent times extended relevance
from the physical environment to outer space/cosmic environment. Such outer space/cosmic environments
were over time reported microbe free, however recent report showed otherwise implicating
space/cosmic travel.

Method:
Diverse interest-based investigators have raised unanswered questions while others yet
remain probable. Bio-scientific evaluation of astro-cosmic dynamics possesses the potential of
revealing the appropriate status, arrangement, and/or position of microbes especially as global
drives focus on controlling microbial spread/proliferation.

Results:
The study determines microbes in space and astro-cosmic environment as vulgar epithet
yet an unattended potential nursing/distribution hub of pathogenic strains applying science mapping
review tools. Using the Preferred-Reporting-Items-for-Systematic-Reviews-and-Meta-
Analyses (PRISMA), major scientific databases (Scopus, Web of Science, and PubMed) were
searched for required and related data on astro-cosmic studies. A 7-decadal evaluation of authors'
published documents using the non-parametric ANOVA test (Kruskal-Wallis H test) and Lotka’s
model was applied. Among the three searched databases, Web of Science ranked least in retrieved
documents (130) followed by PubMed (331) and Scopus (409) with total documents retrieved as
693 between 1954-2023. Further results revealed that production/publication distribution was significant
only in the first decade using Lotk’s model with an annual growth rate of 5.23%. It was
also observed that more than 40 topics of interest/conceptual thematic were trending in association
with astro-microbiological studies.

Conclusion:
A focus on these topics and their associated themes possess the potential for understanding
the future position of the microbes in outer space, the distribution of potentially pathogenic
strains from outer space and necessitates global interest for such studies.
Patient-Centric Mobile Medical Services Accessed Through Smartphones in the Top 100 Chinese Public Hospitals: Cross-Sectional Survey Study
Authors: Huang Xuan , Wang Ying , Yang Xixian , Jiang Ruo , Liu Yicheng , Wang Hui 
Published: December 2024

Background
Smartphone-based technology has been used to enhance the delivery of health care services to the public in numerous countries.

Objective
This study aims to investigate the application of patient-centric mobile medical services accessed through smartphones in the top 100 Chinese public hospitals.

Methods
Data on 124 tertiary public hospitals, ranked among the top 100 by the China Hospital Science and Technology Evaluation Metrics of the Chinese Academy of Medical Sciences (2019) and China’s Hospital Rankings of the Hospital Management Institute of Fudan University (2019), were collected from the WeChat platform (Tencent Inc), mobile phone apps, and official websites until February 10, 2021.

Results
A total of 124 tertiary public hospitals, all of which were among the top 100 hospitals according to the 2 ranking lists, were selected for this study. Almost all (122/124, 98.39%) of the hospitals offered basic services such as appointment scheduling, registration, and health education. The majority also provided online access to test reports (95/124, 76.61%), consultations (72/124, 58.06%), and prescriptions (61/124, 49.19%). Among the hospitals offering online prescriptions, the majority (54/61, 88.52%) supported home delivery through third-party carriers. Slightly less than half (57/124, 45.97%) used artificial intelligence for medical guidance. Only a small fraction (8/124, 6.45%) managed chronic diseases through online monitoring and supervision by experienced doctors. Approximately half (60/124, 48.39%) of the included hospitals were officially licensed as internet hospitals approved to provide full online services. Hospitals with official internet hospital licenses provided more extensive digital health offerings. A significantly higher proportion of approved hospitals offered online consultations (29.69% vs 88.33%, r=43.741; P<.001), test reports (62.5% vs 91.67%, r=14.703; P<.001), and chronic disease management (1.56% vs 11.67%, r=5.238; P<.05). These officially approved hospitals tended to provide over 6 mobile medical services, mainly in the regions of Shanghai and Guangdong. This geographic distribution aligned with the overall layout of hospitals included in the study.

Conclusions
Patient-centric mobile medical services offered by the top 100 Chinese public hospitals accessed through smartphones primarily focus on online appointment scheduling, registration, health education, and accessing test reports. The most popular features include online consultations, prescriptions, medication delivery, medical guidance, and early-stage chronic disease management. Approved internet hospitals offer a significantly greater variety of patient-centric mobile medical services compared with unapproved ones.
The Effects of the COVID-19 Pandemic on Age-Based Disparities in Digital Health Technology Use: Secondary Analysis of the 2017-2022 Health Information National Trends Survey
Authors: Qiu Yuanbo , Huang Huang , Gai Junjie , De Leo Gianluca 
Published: December 2024

Background
The COVID-19 pandemic accelerated the adoption of digital health technology, but it could also impact age-based disparities as existing studies have pointed out. Compared with the pre-pandemic period, whether the rapid digitalization of the health care system during the pandemic widened the age-based disparities over a long period remains unclear.

Objective
This study aimed to analyze the long-term effects of the COVID-19 pandemic on the multifaceted landscape of digital health technology used across diverse age groups among US citizens.

Methods
We conducted the retrospective observational study using the 2017-2022 Health Information National Trends Survey to identify the influence of the COVID-19 pandemic on a wide range of digital health technology use outcomes across various age groups. The sample included 15,505 respondents, which were categorized into 3 age groups: adults (18-44 years), middle-aged adults (45-64 years), and older adults (more than 65 years). We also designated the time point of March 11, 2020, to divide the pre- and post-pandemic periods. Based on these categorizations, multivariate linear probability models were used to assess pre-post changes in digital health technology use, controlling for demographic, socioeconomic, and health-related variables among different age groups.

Results
Essentially, older adults were found to be significantly less likely to use digital health technology compared with adults, with a 26.28% lower likelihood of using the internet for health information (P<.001) and a 32.63% lower likelihood of using health apps (P<.001). The usage of digital health technology for all age groups had significantly increased after the onset of the pandemic, and the age-based disparities became smaller in terms of using the internet to look for health information. However, the disparities have widened for older adults in using the internet to look up test results (11.21%, P<.001) and make appointments (10.03%, P=.006) and using wearable devices to track health (8.31%, P=.01).

Conclusions
Our study reveals a significant increase in the use of digital health technology among all age groups during the pandemic. However, while the disparities in accessing online information have narrowed, age-based disparities, particularly for older adults, have widened in most areas such as looking up test results and making appointments with doctors. Therefore, older adults are more likely left behind by the rapidly digitalized US health care system during the pandemic. Policy makers and health care providers should focus on addressing these disparities to ensure equitable access to digital health resources for US baby boomers.
Comparison of non-linear mixed effect models of the growth curve of commercial turkeys
Authors: Santos-Ricalde Ronald Herbé , Magaña-Monforte Juan Gabriel , Sarmiento-Franco Luis , Parra-Bracamonte Gaspar Manuel , Lemus-Flores Clemente , Avalos-Castro Raúl , Ek-Mex Jesús Enrique , Segura-Correa José Candelario 
Published: December 2024

The description of the growth curve in domestic animals is of importance in management and economic decision-making. The aim here was to determine the best non-linear mixed model to adjust the growth curve in commercial turkeys. The data come from an intensive turkey farm under a subhumid tropical climate. The live weight records of 266 female and 275 male turkeys, weighed weekly, from birth to 23 weeks, were used. The models of Gompertz, yt = A × exp(-b × exp(-k × t)), and von Bertalanffy, yt = A × (1-b × exp(-k × t))3 were used to estimate parameters and predict the growth curve; where: yt = live weight at the t-th week of age; A = the expected mature weight; b = the integration constant; k = the maturation rate. Six non-linear models using the Gompertz, and von Bertalanffy functions: one with only fixed effects, four mixed models considering the fixed, 1 to 3 random effects, and a last model including the random effect of turkey were used. The analyses were performed using the NLMIXED procedure of SAS, and the selection of the best-fit model was chosen based on the Akaike (AIC) and Bayesian (BIC) information criteria. AIC and BIC values improved with the inclusion of 1 to 3 random effects, in both models for females and males. Based on AIC and BIC criteria, the best mixed NLM was the model that included random effects for A, b, and k. However, the predicted weight values of the mixed models were similar.
Pathological, epidemiological features, and statistical study of histopathological changes in chicken transmissible viral proventriculitis
Authors: Merad Djamel Eddine , Zeghdoudi Mourad , Madi Seloua , Bouzid Riad , Aoun Leila 
Published: December 2024

Transmissible viral proventriculitis (TVP) is a chicken disease whose etiology is not fully understood. This study aims to describe histopathological, macroscopic, and epidemiological data associated with possible new etiological agents. The samples comprised 62 broiler farms, 4 laying hen flocks, and 3 broiler breeders. The disease was identified by proventriculus thickening, confirmed through histopathological examination as the most reliable diagnostic method for TVP. Prevalence, clinical signs, gross lesions, epidemiological features, and statistical analysis were calculated. Microscopic findings confirmed the disease, which was classified into three distinct statuses: TVP characterized by the presence of both lymphocytic infiltration and necrosis; lymphocytic proventriculitis (LP) identified by lymphocytic infiltration alone, without the presence of necrosis (WP) denoting cases devoid of both lymphocytic infiltration and necrosis in the proventriculus. These statuses occurred at 23.6 %, 52.8 %, and 23.6 % rates, respectively. The disease prevalence was 20.9 % in flocks aged 15 to 40 days, with a mortality rate from 0.1 % to 0.5 % upon discovery. TVP and LP are marked by intense lymphocytic proliferation and necrosis, hinting at the involvement of infectious agents. Conversely, the absence of these characteristics in WP points to non-infectious etiologies for proventriculitis. The distinct proventricular wall hypertrophy observed in TVP and LP, as opposed to WP, reinforces the interpretation that, only for the conditions of this study, infectious agents amplify existing conditions rather than serve as primary catalysts for the disease.
PROJETO AULA EM CASA NO AMAZONAS
Authors: Ramos de Souza Rosana 
Published: December 2024

O presente artigo é resultado de estudos e pesquisas realizadas em duas escolas da rede estadual do Amazonas durante o período de 2020 e 2021. E teve como objetivo geral conhecer as atividades lúdicas utilizadas pelos professores do 1º ano do Ensino Fundamental, durante o regime de aulas não presenciais. E como específicos, verificar quais foram às atividades lúdicas desenvolvidas pelos professores para os alunos do 1º ano, do Ensino Fundamental durante o período pandêmico, assim como identificar se os docentes obtiveram retorno das atividades propostas os alunos nas aulas on-line e analisar as contribuições das atividades lúdicas para o processo de alfabetização. A pesquisa caracteriza-se por uma pesquisa de natureza qualitativa, e, teve como método de abordagem a fenomenologia, técnicas de coleta de dados a entrevista semiestruturada com professores da rede estadual que lecionaram para os alunos do 1º ano do Ensino Fundamental durante a vigência do regime de aulas não presenciais no ano de 2020. O resultado da entrevista expôs que Projeto Aula em Casa, adotado pela SEDUC/AM não obteve os resultados esperados devido às diversas dificuldades, entre elas, cito a ausência de apoio dos pais e responsáveis na realização das atividades enviadas às crianças, a limitação de acesso à internet, o uso de aparelhos telefônicos e ferramentas digitais.

Palavras-chave: Ludicidade. Anos Iniciais do Ensino Fundamental. Pandemia.
Factors that Influence Customer Satisfaction in Mobile Payment of Online Food Delivery Mobile Applications
Authors: Arshad Yusri , Mohd Sahar Muhamad Afiq , Syed Ibrahim Sharifah Norhafiza , Abdul Latif Mohd Mas Rizat 
Published: December 2024

This study was conducted to determine factors influencing customer satisfaction in mobile payment of online food delivery mobile applications. It uses Technology Acceptance Management, Unified Theory of Acceptance and use of technology, and up-to-date quality of online food delivery. The factors suggested by the theories were perceived ease of use, privacy and security, and e-service quality. A questionnaire was utilized to collect respondents’ answers, and the data collected were analyzed using SPSS. The sample comprised of 269 respondents. It also advantages the researchers in these studies in online food delivery mobile applications to acquire understanding and experience.
Waqf-Based Social Business: A Financial Alternative to Private Tahfiz Institutions
Authors: Misba Nor Tasik , Mat Isa Nurul Amyra , Salleh Nurjannah 
Published: December 2024

Tahfiz institutions are now gaining popularity among Malaysians, and they have a lot of potential to be part of the mainstream education system. The growing demand for Tahfiz has resulted in a rise in the number of Tahfiz institutions in Malaysia especially private Tahfiz owned by individuals. However, most of the private Tahfiz institutions in Malaysia face financial constraints and struggle to obtain sufficient funding for their operations and infrastructure development. This may affect the operation of Tahfiz institutions in general. Therefore, the lack of funds has had many direct and indirect effects on the operation of Tahfiz institutions. Lack of resources, especially financial, hinders the institution's ability to provide a conducive learning environment for students. Tahfiz institutions in Malaysia are completely dependent on student fees as their main source of funds. Thus, this paper aims to propose the role of waqf as an alternative to help Tahfiz institutions, especially private Tahfiz in ensuring the sustainability of their operations. A review of existing literature on waqf education, development of private Tahfiz, and financial constraint. A proposed model was developed to assist the financial burden of private Tahfiz through a Waqf-based Social Business model.
JomRonda : Mobile Application for Security Guard Patrolling
Authors: Binti Bibit Nur’Ain Syafiqah , Binti Abdullah Zamlina , Binti Mior Dahlan Nurazian , Binti Dahlan Azlin 
Published: December 2024

Security patrolling is the process of routinely walking or driving through an area to maintain safety and follow the rules. Few studies discovered issues in security, accuracy and dependability of using non-computerized devices such as watchman clock. One of the issues is hard to monitor the tasks where the watchman tends to avoid their duties by attempting to use the duplicity and adjustment to the watchman’s clock and the key. Yet, the watchman forgets to make daily reports in a logbook at each checkpoint resulting in inaccuracy for authorities to attend and managing any serious emergency. Focussing on the issues, this application is designed with patrolling techniques called geofencing whereby the watchman's location is tracked and data about patrolling is recorded to a database once crosses a virtual boundary. Stakeholders get benefit from the application by keeping track of and reading daily reports digitally. Furthermore, it contains SOS features or international standards for signalling distress allowing users to alert one another in the event of an emergency in the area via a form and an in-app notification. This project follows a methodology known as the Modified Waterfall Model, which entails four stages: requirement gathering and analysis, design, implementation and testing. Future improvements are daily and monthly reporting to authorities can be generated and sent through email. Yet, the application needs temporary storage and the database will be updated as soon as the internet connection is restored.