bluuebunny/crossref_metadata_2025_split huggingface dataset:
Alcohol consumption trajectories and risk of breast cancer among postmenopausal women: a Danish cohort study
Authors: Antoniussen Christian S. , Proust-Lima Cécile , Ibsen Daniel B. , Olsen Anja , Overvad Kim , Tjønneland Anne , Ferrari Pietro , Dahm Christina C. 
Published: December 2024

AbstractAlcohol consumption is a risk factor for breast cancer (BC), yet little is known about longitudinal alcohol consumption patterns and risk of BC. This study aimed to investigate whether trajectory profiles of alcohol consumption across adulthood were associated with risk of first primary malignant BC in postmenopausal women. At baseline, 28,720 pre-and postmenopausal women aged 50–65 years from the Danish Diet, Cancer and Health Cohort reported their average alcohol intake over the past 12 months and their average alcohol intake at the ages of 20, 30, 40, and 50 years. Alcohol consumption trajectories were estimated using latent class mixed models. BC cases were identified through record linkage to the Danish Cancer Registry. To examine associations between alcohol consumption trajectories and BC, we fitted a proportional hazard model adjusted for potential confounding factors using data from 24,543 postmenopausal women without missing covariate information. We identified 4 alcohol consumption trajectory profiles. During a median follow-up of 16.5 years, 1,591 cases of BC occurred. A mean alcohol consumption trajectory of > 10 g/day was associated with higher risk of BC (HR: 1.65, 95%CI: 1.35–2.03) compared to a mean alcohol consumption trajectory of < 6 g/day. We found no association between trajectory profiles characterized by lower alcohol intakes in early adulthood followed by increasing consumption of alcohol in adulthood compared to a consistently low intake of alcohol. Postmenopausal women drinking consistently high amounts of alcohol throughout adulthood had a higher risk of BC compared to women with a consistently low intake of alcohol.
Abundance of fecal indicator bacteria and diversity of Escherichia coli associated with poultry farms and pasture land cover in streams of northwestern South Carolina
Authors: Britt Virginia H. , Liao Min-Ken , Lewis Gregory P. 
Published: December 2024

Abstract
Livestock can contribute fecal indicator bacteria (FIB) to waterbodies. However, few studies have examined the relationship between watershed land use or land cover involving livestock production and the genetic diversity of Escherichia coli in freshwater ecosystems. Our major goal was to determine if FIB abundance and E. coli phylogenetic group distributions in headwater streams are related to livestock production in rural watersheds in South Carolina. In both 2017 and 2018, grab samples were collected from streams at summer baseflow. In 2017, we collected samples from watersheds with or without poultry rearing facilities (PRFs). In 2018, we collected samples from streams draining watersheds with mixed forest and pasture cover and from streams in mostly forested watersheds. In both summers, we measured concentrations of total coliforms, E. coli, and Enterococcus. We also categorized E. coli isolates into one of four phylogenetic groups (A, B1, B2, D). Streams with PRFs in their watersheds had significantly higher concentrations of Enterococcus but not total coliforms or E. coli than streams in watersheds without PRFs. Also, B2 isolates were less frequent and B1 isolates were more frequent in watersheds with PRFs than in those without. Streams draining mixed forest/pasture watersheds had significantly higher concentrations of total coliforms and E. coli but not Enterococcus, as well as higher frequencies of B1 isolates, than streams in mostly forested watersheds. Overall, the most frequent E. coli phylogenetic groups in watersheds with animal production appeared consistent with the phylogenetic groups that are especially abundant in poultry or mammalian livestock feces.
Institutional constraints to higher education datafication: an English case study
Authors: Brooks Rachel , Timms Jill 
Published: December 2024

AbstractStrong claims are made by both higher education policymakers and institutional leaders about the advantages that can be brought about through ‘datafication’ (i.e. the quantification of human activities through digital means). Nevertheless, we know relatively little about how university cultures and processes may impinge on the rolling out of data practices, particularly in relation to administrative data (rather than that collected through learning analytics and other forms of user-generated data). This article draws on a particular case study—of attempts to widen participation to ‘sandwich courses’ in English higher education institutions—to argue that, in some areas of activity at least, institutional constraints serve to limit datafication substantially, including insufficient time and infrastructure, the prioritisation of data required for other purposes (typically national assessment exercises) and the role of institutional cultures. Cognisant of various problems associated with quantification, the article nevertheless contends that the barriers to the effective use of metrics identified in this research may have a direct impact on institutions’ capacity to recognise and address social inequalities.
Classification of human- and AI-generated texts for different languages and domains
Authors: Schaaff Kristina , Schlippe Tim , Mindner Lorenz 
Published: December 2024

AbstractChatbots based on large language models (LLMs) like ChatGPT are available to the wide public. These tools can for instance be used by students to generate essays or whole theses from scratch or by rephrasing an existing text. But how does for instance a teacher know whether a text is written by a student or an AI? In this paper, we investigate perplexity, semantic, list lookup, document, error-based, readability, AI feedback and text vector features to classify human-generated and AI-generated texts from the educational domain as well as news articles. We analyze two scenarios: (1) The detection of text generated by AI from scratch, and (2) the detection of text rephrased by AI. Since we assumed that classification is more difficult when the AI has been prompted to create or rephrase the text in a way that a human would not recognize that it was generated or rephrased by an AI, we also investigate this advanced prompting scenario. To train, fine-tune and test the classifiers, we created the Multilingual Human-AI-Generated Text Corpus which contains human-generated, AI-generated and AI-rephrased texts from the educational domain in English, French, German, and Spanish and English texts from the news domain. We demonstrate that the same features can be used for the detection of AI-generated and AI-rephrased texts from the educational domain in all languages and the detection of AI-generated and AI-rephrased news texts. Our best systems significantly outperform GPTZero and ZeroGPT—state-of-the-art systems for the detection of AI-generated text. Our best text rephrasing detection system even outperforms GPTZero by 181.3% relative in F1-score.
Gender Diversity, Gender Dysphoria/Incongruence, and the Intersection with Autism Spectrum Disorders: An Updated Scoping Review
Authors: Rea Hannah M. , Øien Roald A. , Webb Sara Jane , Bansal Shivam , Strang John F. , Nordahl-Hansen Anders 
Published: December 2024

AbstractIn several ways, 2018 represents a global pivot point in research and care related to the intersection of gender diversity and autism, reflected by the increase in the number of studies on the intersection and broadening of topics. We conducted a scoping review of the literature published between September 2018 and January 2024 to summarize recent research in the field. We compared and contrasted research trends post September 2018 to research that was summarized in previous scoping reviews (Nordahl-Hansen et al. in J Autism Develop Disord 49:1745–1748, 2019; Øien et al. J Autism Develop Disord 48(12):4028–4037, 2018. https://doi.org/10.1007/s10803-018-3843-z). We also summarized systematic reviews and meta-analyses published after 2018. Compared to previous reviews, we included more comprehensive search terms to focus on gender diversity broadly, rather than just gender dysphoria or gender identity disorder, and we included more detailed coding categories to uniquely identify shifts and continuities in research priorities over time. A total of 99 empirical research studies were published after August 2018 (the end of the search in the previous review) and through January 2024 on autism, gender diversity, and related topics were reviewed. There has been growth in the quantity and quality of studies on the intersection of autism and gender diversity, although methodological improvements are still needed and described in the current review. Future research should include more collaborations with stakeholders to set research priorities that are reflective of the communities being described.
Combining crystallographic and binding affinity data towards a novel dataset of small molecule overlays
Authors: Hönig Sophia M. N. , Gutermuth Torben , Ehrt Christiane , Lemmen Christian , Rarey Matthias 
Published: December 2024

Abstract
Although small molecule superposition is a standard technique in drug discovery, a rigorous performance assessment of the corresponding methods is currently challenging. Datasets in this field are sparse, small, tailored to specific applications, unavailable, or outdated. The newly developed LOBSTER set described herein offers a publicly available and method-independent dataset for benchmarking and method optimization. LOBSTER stands for “Ligand Overlays from Binding SiTe Ensemble Representatives”. All ligands were derived from the PDB in a fully automated workflow, including a ligand efficiency filter. So-called ligand ensembles were assembled by aligning identical binding sites. Thus, the ligands within the ensembles are superimposed according to their experimentally determined binding orientation and conformation. Overall, 671 representative ligand ensembles comprise 3583 ligands from 3521 proteins. Altogether, 72,734 ligand pairs based on the ensembles were grouped into ten distinct subsets based on their volume overlap, for the benefit of introducing different degrees of difficulty for evaluating superposition methods. Statistics on the physicochemical properties of the compounds indicate that the dataset represents drug-like compounds. Consensus Diversity Plots show predominantly high Bemis–Murcko scaffold diversity and low median MACCS fingerprint similarity for each ensemble. An analysis of the underlying protein classes further demonstrates the heterogeneity within our dataset. The LOBSTER set offers a variety of applications like benchmarking multiple as well as pairwise alignments, generating training and test sets, for example based on time splits, or empirical software performance evaluation studies. The LOBSTER set is publicly available at https://doi.org/10.5281/zenodo.12658320, representing a stable and versioned data resource. The Python scripts are available at https://github.com/rareylab/LOBSTER, open-source, and allow for updating or recreating superposition sets with different data sources.

Graphical abstract
Simplified illustration of the LOBSTER dataset generation.
Molecular and Clinical Characterization of a Founder Mutation Causing G6PC3 Deficiency
Authors: Zhen Xin , Betti Michael J. , Kars Meltem Ece , Patterson Andrew R. , Medina-Torres Edgar Alejandro , Scheffler Mendoza Selma Cecilia , Herrera Sánchez Diana Andrea , Lopez-Herrera Gabriela , Svyryd Yevgeniya , Mutchinick Osvaldo M. , Gamazon Eric R. , Rathmell Jeffrey C. , Itan Yuval , Markle Janet , O’Farrill Romanillos Patricia , Lugo-Reyes Saul Oswaldo , Martinez-Barricarte Ruben 
Published: December 2024

AbstractG6PC3 deficiency is a monogenic immunometabolic disorder that causes severe congenital neutropenia type 4. Patients display heterogeneous extra-hematological manifestations, contributing to delayed diagnosis. Here, we investigated the origin and functional consequence of the G6PC3 c.210delC variant found in patients of Mexican descent. Based on the shared haplotypes amongst mutation carriers, we estimated that this variant originated from a founder effect in a common ancestor. Furthermore, by ancestry analysis, we concluded that it appeared in the indigenous Mexican population. At the protein level, we showed that this frameshift mutation leads to an aberrant protein expression in overexpression and patient-derived Epstein-Barr Virus-immortalized B (EBV-B) cells. The neutropenia observed in G6PC3-deficient patients is driven by the intracellular accumulation of the metabolite 1,5-anhydroglucitol-6-phosphate (1,5-AG6P) that inhibits glycolysis. We characterized how the c.210delC variant impacts glycolysis by performing extracellular flux assays on patient-derived EBV-B cells. When treated with 1,5-anhydroglucitol (1,5-AG), the precursor to 1,5-AG6P, patient cells exhibited markedly reduced engagement of glycolysis. Finally, we compared the clinical presentation of patients with the mutation c.210delC and all other G6PC3-deficient patients reported in the literature, and we found that the c.210delC carriers display all prominent clinical features observed in prior patients. In conclusion, G6PC3 c.210delC is a loss-of-function mutation that arose from a founder effect in the indigenous Mexican population. These findings may facilitate the diagnosis of additional patients in this geographical area. Moreover, the in vitro 1,5-AG-dependent functional assay used in our study could be employed to assess the pathogenicity of additional G6PC3 variants.
A novel wearable bioimpedance sensor for continuous monitoring of fluid balance: a study on isotonic hypovolemia in healthy adults
Authors: Noddeland Harald , Bremnes Frida , Thorud Anne , Rolid Katrine , Kvaerness Jørn , Jaatun Ellen Andreassen , Aas Sigve Nyvik 
Published: December 2024

AbstractPurpose: This study aimed to investigate the ability of a novel wearable bioimpedance sensor to monitor changes in fluid balance induced by furosemide. Because iso-osmotic fluid loss is expected to primarily comprise fluid from the extracellular compartment it was hypothesized that isotonic hypovolemia would increase the extracellular resistance (RE). Methods: 27 healthy adults (20 women, 7 men; 35 ± 10 year.) were continuously monitored by the bioimpedance sensor following administration of furosemide. Body weight, blood pressure, heart rate, sensation of thirst and selected blood parameters were tested before furosemide administration (t0), one hour (t1) and two hours (t2) after furosemide administration, and one hour after intake of a sports drink containing carbohydrate and electrolytes (t3). Urine elimination was measured throughout the intervention, and the change in extracellular fluid volume was estimated using urine elimination and established equations. Results: During hypovolemia body weight was reduced by 1.4 ± 0.2 kg (1.7 ± 0.4%). Total urine elimination during fluid loss was 1277 ± 190 mL. RE increased significantly from t0 to t2 (13.6 ± 2.9%). A strong correlation was observed between the estimated change in extracellular fluid volume and the measured change in RE during the isotonic fluid loss. Conclusion: This study demonstrates that the wearable bioimpedance device tested is very sensitive to furosemide-induced changes in fluid volume in healthy volunteers in a controlled environment. Additional research is needed to evaluate the ability of the device to track fluid status in a clinical setting. Trial registration: The study was registered at clinicaltrials.gov 29th of October 2021 (NCT05129358).
Fittingness and Well-Being
Authors: Hooker Brad 
Published: December 2024

AbstractMental states (beliefs, emotions, moods, desires, etc.) towards things can fit or fail to fit those things. Perhaps actions can fit or fail to fit the situations in which they are done. This paper explores whether having fitting mental states and doing fitting actions can constitute additions to a person’s well-being. The paper first discusses the desire-fulfilment theory of well-being. Then the paper considers hedonistic theories of well-being and criticises the recent proposal from Rossi and Tappolet that well-being consists only in fitting happiness. Then the paper turns to the objective list theory of well-being and Badhwar’s Aristotelian theory. In this context, the paper considers Bruno-Niño’s recent argument for fitting attitudes as a part of well-being. Finally, the paper explores whether, on the objective list theory and Badhwar’s theory, doing fitting actions constitutes an element of well-being. The upshots are that fittingness is not an element of well-being according to some theories of well-being and that it is an element of well-being either contingently or necessarily according to other theories of well-being.
Religious and Spiritual Experiences, Discrimination, and Stress Among Midlife Women in the USA: The Study of Women’s Health Across the Nation
Authors: Barnes Marilyn J. D. , Janssen Imke , Dugan Sheila A. , Kravitz Howard M. , Fitchett George 
Published: December 2024

Abstract
The harmful effects of perceived discrimination for physical and mental health are well documented. Evidence identifies how dimensions of religious/spiritual (R/S) involvement may reduce these harmful effects. This study examined how R/S experiences are associated with the effects of discrimination on perceived stress. With data from the Study of Women’s Health Across the Nation (SWAN), we examined the offsetting and buffering effects of daily spiritual experiences on the relationship between everyday discrimination and perceived stress among 2,221 US midlife women from 5 racial/ethnic groups. Regression analysis identified a positive association between perceived discrimination and perceived stress (p < .001). Daily spiritual experiences were inversely associated with perceived stress (p < .001) for the whole sample and in the subsample of Black women. For this subsample, there was an inverse association between daily spiritual experiences and discrimination. R/S experiences may be one of the ways that R/S reduce the harmful effects of discrimination on health.
“With the Pandemic Still Raging, I am Blessed to Do My Part to Defeat it”: Exploring COVID-19 Jewish Liturgy and Prayers in Israel and the United States
Authors: Ben-Lulu Elazar 
Published: December 2024

Abstract
During the COVID-19 pandemic, synagogues faced closure, and many non-Orthodox communities transitioned their prayer services to online platforms. This presented a significant challenge for community leaders and rabbis who were faced with a profound community crisis. An innovative response emerged including new prayers and the adaptation of existing ones to better address the pandemic’s unique realities, integrating aspects of health, divinity, community, and the environment. This study engages in a textual analysis of these prayers, exploring how these mirror cultural and social attitudes toward the body and embodiment. While the body was seen during the COVID-19 period as problematic, an object of contagion and spreader of disease (e.g., by not keeping proper distance or masking), in these particular texts it is no longer slandered, but revealed as an obedient and disciplined agent. The prayers seek to overcome the disruption in the individual’s relationship with their body and with other bodies. The prayer authors propose to the worshipper, while also conceptually changing traditional ideas and practices, to view the body as an object that must be cleaned, vaccinated, purified, and allowed to continue its function. The concern for both the well-being of the living body and the dignity of the deceased extends to care for society and humanity as a whole. Therefore, this liturgy can be seen as a pragmatic means to promote a “theology of humanistic responsibility.”
Developmental Relations Between Peer Victimization, Emotional Symptoms, and Disability/Chronic Condition in Adolescence: Are Within- or Between-Person Factors Driving Development?
Authors: Turner Russell , Bjereld Ylva , Augustine Lilly 
Published: December 2024

AbstractAlthough there is a link between peer victimization, emotional symptoms, and disability or chronic condition in adolescence, less is known about the role of stable, individual differences compared to developmental processes. The current study addressed this gap by examining developmental relations between peer victimization, emotional symptoms, and disability or chronic condition. Three waves of self-report panel data on Swedish adolescents at ages 13, 15, and 17 years (n = 734; 51.6% girls) were used. Data were analyzed using random-intercept cross-lagged panel models with invariance tests by sex, disability/chronic condition, and family affluence. Girls and adolescents with a disability or chronic condition showed more heterogeneity in the co-development of peer victimization and emotional symptoms, with girls being more prone than boys to developing emotional symptoms following peer victimization, and particularly in early adolescence. Girls and adolescents with a disability or chronic condition had elevated within-person levels of both peer victimization and emotional symptoms throughout adolescence. Theory and practice may need to pay additional attention to the role of sex, disability, and their intersection, as well as age, regarding the development of peer victimization and emotional symptoms.
Mobile sensing system for phenotyping of forest seedlings in container nurseries
Authors: Durło Grzegorz , Szymanski Norbert , Małek Stanisław 
Published: December 2024

Abstract
The primary objective of this study was to develop a universal, lightweight, and mobile system that seamlessly integrates the scanner with the construction of the horizontal spray boom at a forest nursery. This innovative approach holds tremendous potential for advancing the assessment and management of forest seedlings, providing valuable insights and streamlining nursery operations. Multichannel spectral devices mounted on irrigation booms can be used to significantly enhance the quality assessment of forest seedlings in container nurseries. Contrary to traditional and time-consuming approaches such as laboratory analysis or destructive sampling, an active canopy optical sensor operates independently of ambient light conditions and does not necessitate spectral reference readings. Mobile irrigation systems in nurseries are ideal for incorporating plant scanners owing to their exceptional repeatability, ensuring consistently high-quality results. In our study, we rigorously tested a set of four ACS 435 Holland Scientific active crop canopy sensor along with the Vega Plus C21 laser sensor, all strategically positioned on a sprinkler boom above the nursery production field from May to September 2022. The seamless integration of these devices with the GeoSCOUT X Holland Scientific data acquisition unit formed the foundation of our system. The primary objective of this study was to develop a universal, lightweight, and mobile system that seamlessly integrates the scanner with the construction of the horizontal spray boom at a forest nursery. This innovative approach holds tremendous potential for advancing the assessment and management of forest seedlings, providing valuable insights and streamlining nursery operations.