bluuebunny/crossref_metadata_2025_split huggingface dataset:
Flight-Time Method Modified: Development of a Novel and More Accurate Method for Measuring Vertical Jump Height Using a Smartphone Application
Authors: Nishioka Takuya , Yamaguchi Shota , Inami Takayuki 
Published: November 2024

Purpose: The flight-time method (FT) is used for measuring vertical jump height (JH) in the field because of its convenience; however, FT overestimates JH when the lower limb is flexed at landing. Herein, we proposed a new method (ie, flight-time method modified [FTM]) to address the problem of FT and evaluate its validity and reliability. Methods: A total of 24 men performed 6 countermovement jumps on force plates (sampling rate: 1000 Hz) while being recorded with a smartphone high-speed camera at 240 frames·s–1. JH was calculated by the impulse–momentum method (IM), FT, and FTM. For FTM, the flight time and JH were calculated based on the displacement of the greater-trochanter marker using a smartphone application. Results: JH calculated using FT was significantly higher (P < .001) compared with JH calculated by IM; however, JH calculated by FTM showed no significant difference with JH calculated by IM. Furthermore, JH calculated by FTM, compared with JH calculated by FT (ρ = .882; 95% CI, .838–.914), exhibited a stronger, nearly perfect, and significantly positive correlation (ρ = .987; 95% CI, .982–.991) with JH calculated by IM and showed high reliability. Conclusions: The FTM proposed in this study had higher concurrent validity compared with FT and a high reliability for measuring countermovement JH because it was not affected by lower-extremity flexion at landing. Therefore, practitioners should consider using FTM as a convenient, low-cost, reliable, and more valid method for measuring JH in the field.
Contextual Measurement of Sources of Exercise Amotivation: The Revised Amotivation Toward Exercise Scale-2
Authors: Vlachopoulos Symeon P. 
Published: November 2024

The aim of the study was to modify the Amotivation Toward Exercise Scale-2 by dropping the outcome amotivation beliefs subscale while retaining the capacity, effort, value, and task characteristics amotivation beliefs. Data from 515 Greek nonexerciser adults aged 19–64 years and 399 Greek nonexerciser older adults aged 65–82 years, men and women, supported the latent four-factor structure of the Revised Amotivation Toward Exercise Scale-2 scores within each sample separately. The hierarchical model was also supported. Measurement invariance of Revised Amotivation Toward Exercise Scale-2 scores was supported across groups of gender, age, body mass index, and educational levels within adults and older adults. Configural measurement invariance supported a replicable factor structure across adults and older adults. Metric and strong invariance was supported across middle-aged and older adults but not between younger and older adults. Full measurement invariance was supported between younger and middle-aged adults.
Risk-stratified hepatocellular carcinoma screening according to the degree of obesity and progression to cirrhosis for diabetic patients with metabolic dysfunction-associated steatotic liver disease (MASLD) in Japan: a cost-effectiveness study
Authors: Kowada Akiko 
Published: November 2024

ObjectiveTo evaluate the cost-effectiveness of risk-stratified hepatocellular carcinoma (HCC) screening in diabetic patients with metabolic dysfunction-associated steatotic liver disease (MASLD).DesignA state-transition model from a healthcare payer perspective on a lifetime horizon.SettingJapan.PopulationA hypothetical cohort of 50-year-old diabetic patients with MASLD risk-stratified according to degree of obesity and progression to cirrhosis. Metabolic dysfunction-associated steatotic liver (MASL), metabolic dysfunction-associated steatohepatitis (MASH) and MASH cirrhosis are progressive manifestations of this specific type of liver disease.InterventionAbdominal ultrasound (US), US with alpha-fetoprotein (AFP), US with AFP and lectin-reactive alpha-fetoprotein (AFP-L3), CT, extracellular contrast-media-enhanced MRI (ECCM-MRI), gadoxetic acid-enhanced MRI (EOB-MRI) and no screening.Main outcome measureCosts, quality-adjusted life-years (QALYs), incremental cost-effectiveness ratios (ICERs), early-stage HCC cases, advanced-stage HCC cases and HCC-related deaths.ResultsEOB-MRI is the most cost-effective screening method for non-obese diabetic patients with MASH cirrhosis and for obese diabetic patients with MASH and MASH cirrhosis. Cost-effectiveness was sensitive to HCC incidence in non-obese diabetic patients with MASH cirrhosis and obese diabetic patients with MASH, and the adherence rate of HCC screening in obese diabetic patients with MASH. When the semiannual HCC incidence was between 0.008 and 0.0138 in non-obese diabetic patients with MASH cirrhosis, US with AFP was more cost-effective than EOB-MRI. Cost-effectiveness acceptability curves showed that EOB-MRI was 50.7%, 96.0% and 99.9% cost-effective in obese diabetic patients with MASH and non-obese diabetic patients with MASH cirrhosis, and obese diabetic patients with MASH cirrhosis at a willingness-to-pay level of $50 000 per QALY gained. Compared with no screening in 100 000 non-obese diabetic patients with MASH cirrhosis and obese diabetic patients with MASH cirrhosis, EOB-MRI reduced total costs by US$69 million and by US$142 million, increased lifetime effectiveness by 12 546 QALYs and by 15 815 QALYs, detected 17 873 and 21 014 early-stage HCC cases, and averted 2068 and 2471 HCC-related deaths, respectively.ConclusionsOf all HCC screening methods for diabetic patients with MASH cirrhosis, EOB-MRI yields the greatest cost-saving with the highest QALYs, detects the greatest number of early-stage HCC cases and averts the greatest number of advanced-stage HCC cases and HCC-related deaths. The findings provide important insights for the precise implementation of risk-stratified HCC surveillance to reduce morbidity and mortality and improve the quality of life in diabetic patients with MASLD.
Quality appraisal of clinical guidelines for peripherally inserted central catheter-related thrombosis prophylaxis in patients: a systematic review
Authors: Zhang Ning , Xu Yuan , Zhu Li Yun , Wang Yu , Lu Qiaodan , An Ranxun , Zhou Xin-Yi , Wang Xiao Jie , Ma Yufen 
Published: November 2024

ObjectivesTo evaluate and analyse the quality of clinical practice guidelines for Peripherally Inserted Central Catheter-related thrombosis (PICC-related thrombosis) to identify the most current and effective prophylactic measures recommended in the guidelines.DesignScoring and analysis of the guidelines using the Appraisal of Guidelines for Research and Evaluation II (AGREE II).Data sourcesCochrane Library, PubMed, EMBASE, Cumulative Index of Nursing and Allied Health Literature (CINAHL), Chinese databases (China National Knowledge Infrastructure and Wan Fang) and the relevant websites of the guideline were searched through 8 August 2024.Eligibility criteria for selecting studiesStudies that primarily clinical practice guidelines on the prevention of PICC-related thrombosis were included.Data extraction and synthesisTwo reviewers independently screened the searched items and extracted data and scored documents using AGREE II. Findings were summarised in Grading of Recommendation, Assessment, Development and Evaluation (GRADE) evidence profiles and synthesised qualitatively.ResultsThe analysis incorporated a total of nine guidelines, all rated as ‘recommended’ or ‘recommended with modifications’. Standardised scores revealed elevated performance in the domains of Scope and Purpose, Clarity of Presentation and Editorial Independence. Conversely, the Stakeholder Involvement and Applicability domains yielded the lowest average standardised scores. Disparities in standardised scores across guidelines were particularly evident in the domains of Rigour of Development, Stakeholder Involvement and Applicability. The agreement between the two appraisers was almost perfect (intraclass correlation coefficients higher than 0.80). A considerable proportion of recommendations relied on evidence of low-quality, in certain instances, were derived from expert opinions within working groups.ConclusionsThe review reveals that a significant portion of recommendations relies on low-quality evidence. Guideline developers are urged to prioritise methodological quality, with a specific focus on refining Stakeholder Involvement and Applicability domains. Addressing these aspects will enhance the overall quality and reliability of PICC-related thrombosis prevention guidelines. One potential way to mitigate these challenges is to endorse a standardised approach to guideline development and to synthesise reliable clinical evidence to reduce variation in recommendations.PROSPERO registration numberCRD42023495519.
Intra-arterial alteplase for acute ischaemic stroke after mechanical thrombectomy (PEARL): rationale and design of a multicentre, prospective, open-label, blinded-endpoint, randomised controlled trial
Authors: Yang Xinguang , He Xiongjun , Pan Dong , Xu Yongteng , Peng Huiyuan , Li Kaifeng , Zhang Min , Zhu Yingying , Chen Yanting , He Baixuan , Zhou Hongxing , Li Jie , Hou Hongbiao , Sun Haoyang , Liu Yajie , Tang Yamei 
Published: November 2024

IntroductionSuccessful reperfusion does not always lead to good neurological outcomes and impaired microcirculation can be one of the underlying causes. Intra-arterial alteplase after mechanical thrombectomy (MT) may improve microcirculation contributing to neurological recovery, but prospective randomised studies are still needed to validate its efficacy and safety. We aim to assess the efficacy and safety of intra-arterial alteplase after MT for acute ischaemic stroke (AIS) with large-vessel occlusion (LVO).Methods and analysisTheIntra-arterial Alteplase for Acute Ischaemic Stroke After Mechanical Thrombectomy(PEARL) study is a multicentre, prospective, open-label, blinded-endpoint, randomised controlled trial. We consecutively screen AIS patients with anterior circulation LVO and National Institute of Health Stroke Scale of 6–25, who reach stable expanded Thrombolysis in Cerebral Infarction scores of 2b50-3 on angiography after MT. Eligible participants are 1:1 randomly assigned to the experimental group and the control group. Participants in the experimental group will receive intra-arterial alteplase (0.225 mg/kg and a maximum dose of 20 mg) after MT and standard medical treatment, while those in the control group will receive standard medical treatment alone after the procedure. The primary outcome is the proportion of patients with a 90-day modified Rankin scale of 0–1. A total of 324 participants are required to test the superiority hypothesis with 80% power at a two-tailed significance level of 0.05.Ethics and disseminationThis study has been approved by the Ethics Committee of Sun Yat-sen Memorial Hospital, Sun Yat-sen University (SYSKY-2023-390-02) and will be conducted following the Declaration of Helsinki. Ethical approvals have been obtained separately for all centres participating in the study. Study results will be published in peer-reviewed academic journals.Trial registration numberNCT05856851.
Successful cutaneous sensory blockade following single-injection and double-injection techniques of ultrasound-guided superficial parasternal intercostal plane block: a randomized clinical trial
Authors: Samerchua Artid , Sroiwong Chalita , Lapisatepun Panuwat , Leurcharusmee Prangmalee , Pipanmekaporn Tanyong , Sukhupragarn Wariya , Boonsri Settapong , Bunchungmongkol Nutchanart , Pansuan Kittitorn , Phothikun Amarit 
Published: November 2024

BackgroundWhile superficial parasternal intercostal plane blocks can improve analgesia after cardiac surgery, the optimal site and the number of injections remain uncertain. This study aimed to compare the efficacy of single versus double injections of superficial parasternal blocks, hypothesizing that double injections would achieve superior cutaneous sensory blockade.Methods70 cardiac patients undergoing median sternotomy were randomly assigned to receive either single or double injections of superficial parasternal blocks bilaterally. Each patient received 40 mL of 0.25% bupivacaine with epinephrine 5 µg/mL and dexamethasone 10 mg. The single-injection group received 20 mL/side at the third costal cartilage, while the double-injection group received 10 mL/injection at the second and fourth costal cartilages. The primary outcome was a successful block, defined as sensory loss in the T2–T6 dermatomes. Secondary outcomes included sensory block of T1, T7, and T8 dermatomes, block-related complications, intraoperative hemodynamics, postoperative pain intensity, opioid consumption, and recovery quality.ResultsDouble injections achieved an overall higher success rate compared with the single-injection technique (81% vs 51%, relative risk 1.6; 95% CI 1.2, 2.0; p<0.001). Additionally, higher blockade percentages were observed in dermatomes T1 (83% vs 59%, p=0.003), T7 (67% vs 46%, p=0.017), and T8 (61% vs 39%, p=0.011) with double injections. Other secondary outcomes did not differ significantly between groups.ConclusionsCompared with single injection, double injections of superficial parasternal blocks provided more reliable coverage of the T2–T6 dermatomes, crucial for median sternotomy. However, no differences were observed in intraoperative hemodynamic effects or postoperative pain control after cardiac surgery.Trial registration numberTCTR20230408004.
Palliative care in severe mental disorders: a scoping review
Authors: Sousa Alexia Jade Machado , Jorge Maria Salete Bessa , Lourenço Eric Wenda Ribeiro , Fernandes Helder Matheus Alves , de Sousa Marina Ferreira 
Published: November 2024

BackgroundThe WHO defines palliative care (PC) as an approach to improving the quality of life for patients and their families. Within this context, palliative psychiatry (PP) emerges. The present study undertakes a scoping review of research on the applicability of PC in people with severe mental disorders.MethodsNine online databases were used to identify articles published without time or language restrictions, from which 17 records were selected. These records originated from eight countries and covered eight psychiatric diagnostic groups.ResultsA descriptive synthesis of the eligible studies was conducted, which were then analysed using content analysis techniques. From the thematic analysis, three main themes emerged: general aspects of PP, critical reflections on the application of care and the strategies employed in this field.ConclusionsDespite the growing definition of PP, the literature remains scarce, with few studies focused on PC for psychiatric disorders, leading to a neglect of such care. There is a significant demand for more empirical research and diverse approaches that include narratives and evaluations from patients and their families.Trial registration numberThe protocol for this review was registered on the Open Science Framework platform under the DOI number: 10.17605/OSF.IO/3ZVN5.
Utility of Gold/Multiwalled Carbon Nanocomposite for Electrochemical Determination of Omarigliptin in Tablets and Human Plasma
Authors: Abdel-Hakim Ali , Hashem Heba M. , Belal Fathalla , Hammad Mohamed A. , El-Maghrabey Mahmoud 
Published: November 2024

An innovative voltammetric sensor was developed to estimate omarigliptin, a novel long-acting anti-diabetic drug. The sensor utilized a carbon paste electrode enhanced with a nanocomposite of carbon nanotubes and electrodeposited gold nanoparticles. The modified electrode was characterized using scanning electron microscopy and electrochemical impedance spectroscopy. The modification significantly improved the electrode’s sensitivity and electrochemical efficiency and decreased its electron transfer resistance. The surface area of the modified electrode increased by about 2.8-fold compared to the bare electrode. Omarigliptin’s oxidation behavior on the modified electrode was pH-dependent and irreversible, resulting in a peak current 4 times higher than the unmodified electrode. The modified electrode revealed good reproducibility, reusability, and stability. It allows for sensitive voltammetric analysis of omarigliptin over a linear range of 0.4–27 μM (LOD = 0.12 μM) and good applicability in tablets and plasma. The recovery percentages were 98.47%–101.27% in tablets and 95.86%–105.02% in plasma. The modified electrode exhibits good selectivity towards omarigliptin without interference from tablet excipients, endogenous plasma components, and co-administered drugs. The comparison with the reported methods reveals the superiority of the proposed method in terms of sensitivity, selectivity, applicability, and eco-friendliness. Finally, the proposed method demonstrates excellent environmental profiles based on recent assessment metrics.
Penile Metastasis‐Induced Priapism as the First Sign of Lung Cancer: A Case Report and Review of the Literature
Authors: Abou Zahr Rawad , Nadalin Eliott , Thiry Sarah , Da Silva Maia Raquel , Feyaerts Axel , Tombal Bertrand 
Published: November 2024

Background: The penis is a relatively uncommon organ for metastases. Secondary lesions often originate from the bladder, prostate, or rectosigmoid cancers. Only a few cases have described penile lesions secondary to lung cancers, mostly as a later complication.Case Description: We hereby report the case of an 86‐year‐old male patient who presented with a 3‐week‐long nonpainful priapism. A penile Doppler ultrasound and a chest and abdominal CT scan were performed, showing a left hilar lung mass as well as lesions in the liver, the adrenal glands, the pancreas, bone structures, and the penis. Penile metastasis is associated with a poor prognosis because of the frequent disseminated malignant lesions in other sites.Conclusion: Malignant priapism should be suspected, especially in patients with no evident risk factors for priapism (hematological diseases, drugs, alcohol, neurological diseases, or metabolic disorders).
Bioinformatics Analysis and Experimental Findings Reveal the Therapeutic Actions and Targets of Cyathulae Radix Against Type 2 Diabetes Mellitus
Authors: Zhang Xi , Sun Zijin , Sun Wenlong , Li Yueming , Gao Fei , Teng Fei , Han Zhenxu , Lu Yanting , Zhang Shuo , Li Lingru 
Published: November 2024

Objective: This study elucidated the mechanistic role of Cyathulae Radix (CR) in type 2 diabetes mellitus (T2DM) through bioinformatics analysis and experimental validation.Methods: Components and targets of CR were retrieved from the traditional Chinese medical systems pharmacology, while potential T2DM targets were obtained from GeneCards and Online Mendelian Inheritance in Man databases. Intersecting these datasets yielded target genes between CR and T2DM. Differential genes were used for constructing a protein–protein interaction network, followed by Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses. Molecular docking and dynamics simulations were performed using AutoDock and GROMACS, respectively, and in vitro experiments validated the results. Experiments evaluated the effect of CR on T2DM pancreatic β‐cells.Results: Bioinformatics analysis identified four active compounds of CR, 157 related genes, and 5431 T2DM target genes, with 141 shared targets. Key targets such as JUN, MAPK1, and MAPK14 were identified through topological analysis of the PPI network. GO analysis presented 2663 entries, while KEGG analysis identified 161 pathways. The molecular docking results demonstrated favorable binding energy between the core components and the core proteins. Among them, JUN‐rubrosterone, MAPK1‐rubrosterone, and MAPK14‐rubrosterone deserved further investigation. Molecular dynamics results indicated that all of them can form stable binding interactions. CR could inhibit the expression of JUN, MAPK1, and MAPK14, promote insulin secretion, alleviate apoptosis, and regulate autophagy in INS‐1 cells.Conclusion: This study suggests CR approach to T2DM management by multitarget and multipathway provides a scientific basis for further research on the hypoglycemic effect of CR.
Development of the Japanese Version of Rushton Moral Resilience Scale (RMRS) for Healthcare Professionals: Assessing Reliability and Validity
Authors: Wataya Keiko , Ujihara Masana , Kawashima Yoshitaka , Sasahara Shinichiro , Takahashi Sho , Matsuura Asako , Lebowitz Adam , Tachikawa Hirokazu 
Published: November 2024

Aim: To translate the Rushton Moral Resilience Scale (RMRS) into Japanese and validate its applicability among Japanese healthcare professionals.Background: To overcome daily challenges in the field of healthcare, in which moral difficulties are routinely encountered, the development of intervention methods to address moral suffering and moral distress is crucial.Methods: We conducted a cross‐sectional survey using a web‐based questionnaire. The RMRS‐16 was translated into Japanese and confirmed through back‐translation. Reliability analyses (Cronbach’s alpha and intraclass correlation coefficient [ICC]), confirmatory factor analyses (CFAs), correlation analyses, t‐tests, and analysis of variance (ANOVA) were used to assess the validity of the scale.Results: Participants comprised 1295 healthcare professionals, including 498 nurses. All subscales and the total scale had acceptable reliability values (α ≥ 0.70). CFA supported the original four‐factor structure (response to moral adversity, personal integrity, relational integrity, and moral efficacy), with acceptable fit indices. The ANOVA results suggested that, among Japanese healthcare professionals, nurses and individuals from other professions showed lower average moral resilience scores compared to physicians, consistent with previous research on mental health and moral distress. In addition, women scored lower for moral resilience than men. However, the ICC values for the subscales of the RMRS were below acceptable levels, and the results of the standardized residual covariances also suggested a model misfit.Conclusion and Implications: The reliability, validity, and utility of the Japanese version of the RMRS were generally supported. However, there were areas at the item level that required structural examination. The current findings suggest that there are cultural differences in the concept of moral resilience. Therefore, for future cultural comparisons, the original four‐factor structure was maintained in the Japanese version without modifications. Further conceptual development of moral resilience is needed in Japanese healthcare.