bluuebunny/crossref_metadata_2025_split huggingface dataset:
Команда чекістів-ліквідаторів. Передчасна смерть В. Мурського: невиліковна хвороба чи спецоперація ОДПУ (1935 р.)
Authors: Підгірна Лариса 
Published: November 2024

У 1935 році, у Стамбулі, у віці сорока семи років, від онкологічного захворювання передчасно помирає очільник нелегальної резидентури «Стамбульська платформа», представник ДЦ УНР в екзилі, фаховий журналіст і дипломат В. Мурський. Його смерть, фактично зводить нанівець всі проєкти та напрацювання нелегальної резидентури і на довгі десятиліття відкладає отримання Православною церквою України жаданої автокефалії. За кілька місяців по смерті В. Мурського передчасно помирає і лояльний до української політичної еміграції та вирішення питання надання ПЦУ Томосу, Вселенський Патріарх, Фотій II. На думку авторки, такі послідовні передчасні смерті могли бути не випадковими.
З 1929 по 1935 рр. в Стамбулі діяли кадрові представники радянської розвідки, знані як «фахівці по Сходу» та професійні кілери Я. Блюмкін, Н. Ейтінгон в Г. Агабеков, у «послужному списку» яких було чимало спецоперацій по ліквідації неугодних радянській владі осіб - лідерів національного спротиву, релігійних лідерів, очільників білогвардійського руху, радянських біженців і, навіть, колег-чекістів. Авторка досліджує припущення, висунуте й іншими науковцями - можливість ліквідації В. Мурського радянськими спецслужбами.
Дослідивши хронологічний ланцюжок подій і застосувавши емпіричний та інші наукові методи дослідження, авторка робить цілком обґрунтоване припущення, що ліквідація керівника нелегальної резидентури ДЦ УНР в екзилі, «Стамбульської платформи», В. Мурського агентами радянської розвідки за допомогою розробок радянської відомчої токсикологічної лабораторії «Спеціальний кабінет» була абсолютно можливою.
Михайло Грушевський як професор Львівського університету: курси, навантаження, розклад занять
Authors: Telvak Vitalii , Hubytskyy Liubomyr 
Published: November 2024

Мета статті – дослідити дидактичне навантаження М. Грушевського у Львівському університеті, тижневий розклад його занять, особливості викладання лекцій і семінару, а також комунікацію з факультетською адміністрацією.
Методологічне підґрунтя роботи становить міждисциплінарний підхід. Особливий акцент зроблено на структурно-функціональному системному аналізі історіографічних фактів і порівняльно-історичному методі, виходячи з принципів об’єктивності та історизму.
Наукова новизна дослідження полягає у першій спеціальній спробі комплексної реконструкції образу М. Грушевського як професора Львівського університету.
Висновки. Викладацька діяльність М. Грушевського у Львівському університеті була покликана втілити задум київських і львівських народовців з послідовного перетворення Галичини на національний «П’ємонт». Властиво визначний історик повинен був реалізувати освітню складову цього культурно-громадського проєкту, готуючи нові кадри україністів зі студіюючої молоді головного навчального закладу краю. Відповідно до цієї місії, він розробив і послідовно за періодами викладав лекційні курси національної історії та східноєвропейського регіону. Заохочені такою проблематикою студенти поглиблювали українознавчу спеціалізацію на науковому семінарі і багатьох спецкурсах М. Грушевського з кола політичної, соціокультурної та регіональної історії.
Цей суто дидактичний процес, сфокусований на всебічному обґрунтуванні історичної суб’єктності українського народу, мав очікуваний громадський ефект. Він полягав у розгортанні боротьби за культурні права українців у стінах Львівського університету. Саме М. Грушевський став ідеологом цих змагань і у власній професорській практиці принципово утверджував український голос у національній поліфонії університету, показуючи приклад більш поміркованим колегам К. Студинському та О. Колессі. Підсумком професорської діяльності визначного вченого стали численні кадри національної інтелігенції, які протягом 20 ст. завершили його масштабну справу з інтеграції українських сюжетів до світового історичного процесу.
Єврейське питання у Катеринославі на початку 20 століття
Authors: Savchenko Serhiy , Reshetilova Oksana 
Published: November 2024

Мета статті – у суспільно-політичному контексті проаналізувати єврейське питання у Катеринославі початку 20 ст., виявити роль монархічних сил в антисемітській політиці, місцевої влади, окремих кіл громадськості.
Наукова новизна. Відтворено соціально-психологічний контекст ескалації расово мотивованого насильства; показано специфіку розуміння націоналізму на локальному «обивательському» рівні; виявлено відсутність історіографічної традиції вивчення катеринославського антисемітизму; на підставі незалучених до дослідницького процесу архівних джерел відтворено специфіку погромницької політики у Катеринославі та проаналізовано мотивацію учасників погромницьких акцій; охарактеризовано роль чорносотенців у поширенні антисемітизму на місцевому рівні; відтворено атмосферу неоднозначного сприйняття імперсько-монархічних сил губернською владою; окреслено дозвільно-цензурну політику в Катеринославі щодо євреїв та єврейських установ.
Висновки. Антисемітизм був принциповим і безкомпромісним складником ідеології та політики катеринославських чорносотенців, який відмежовував їх від будь-яких суспільно-політичних рухів і партій того часу та завдавав непоправної репутаційної шкоди всьому правому монархічному рухові. У цьому пункті увиразнилися особливі риси російської модерної ідентичності, які викликали негативне суспільне сприйняття та були історично безперспективними. Ставлення владних кіл Катеринославщини до єврейського питання було складним, неоднозначним і суперечливим: вони були змушені шукати баланс між урядовим антиєврейським курсом, антисемітизмом місцевих чорносотенців, ліберальною та лівою громадськістю, що зазвичай захищала євреїв, а також єврейськими силами, що були вагомою частиною фінансового та господарчого життя Придніпров’я.
Development of Education in Elbasan Prefecture (Albania) in 1928-1939
Authors: Sinani Arsim , Mita Rudina 
Published: November 2024

The purpose of the research paper is to analyze the development of education in Elbasan Prefecture in 1928-1939, to determine the general condition of schools and their number, teaching staff, class attendance, etc., as well as to show problems and achievements in the field of education.
The scientific novelty. This issue has not been considered in the current historiography, which made it possible for the first time to describe in detail the educational situation in the Prefecture by level of education and geographical distribution.
Conclusions. Even though Elbasan was one of the most developed regions of Albania, the illiteracy rate in the early 20th century reached 90% of the population. During 1920-1928, the government took some steps to improve the situation in the field of education but they were insignificant, which was determined by the historical and political situation, economic problems, social bigotry, and the patriarchal way of life of an average family.
In 1928-1939, the Albanian government intensified its educational policy, which manifested itself in the following steps: establishing an educational structure with a solid foundation for primary and secondary education; training of teaching staff; improving school curricula at each level of education; improving school infrastructure; conducting and implementing an awareness-raising policy in the country to include a female element in education, etc.
The support of the local government, volunteerism, and charity of the wealthy families of Elbasan became important supporting factors in the development of education, which was confirmed by the donations of buildings for educational and cultural needs, financial support, and voluntary help of the residents of Elbasan in the construction of educational and cultural institutions.
Strong support for education in the Prefecture was provided by local intellectuals who graduated from schools in Western Europe and beyond. They made an important contribution both to introducing of a new liberating spirit into the country and to adapting of school curricula to the needs of the country and the Albanian tradition, using the best experience of countries such as Austria, Italy, and others.
Research hotspots and trends in immunotherapy for cholangiocarcinoma: a bibliometric analysis (2014-2023)
Authors: Qu Xilin , Wang Qian , Zhu Fengfeng , Liang Hao , Long Zhangtao , Wu Yachen , Jiang Mengliang , Liu Zhaohai , Dai Xiaoming , Zhu Zhu 
Published: November 2024

BackgroundCholangiocarcinoma (CCA) is a malignant tumor of the gastrointestinal tract with a poor prognosis. Immunotherapy plays an important role in the treatment of CCA. This study aimed to investigate the research hotspots and trends in immunotherapy for CCA.MethodsThe Web of Science Core Collection was searched for literature related to CCA immunotherapy research from January 1, 2014, to December 31, 2023, and features such as country, institution, authors, references, and keywords in the included literature were quantitatively and visually analyzed using the VOS viewer and CiteSpace software.ResultsA total of 252 English publications published between 2014 and 2023 were included. The publications were mainly from China and the United States, with Fudan University being the institution that published the most papers. The highest number of publications came from Frontiers in Oncology. The most prolific authors were Jia Fan, Jian Zhou from China and Pa-Thai Yenchitsomanus from Thailand, while the Journal of Clinical Oncology ranked first in the number of citations among the co-cited journals. In recent years, the focus of research has shifted from “immune checkpoint” and “chemotherapy” to “immunotherapy combined therapy.” Currently, the research frontiers are “microenvironment,” “immune cells,” and “macrophages.”ConclusionOur study analyzes the research hotspots and trends in CCA to provide a knowledge map of immunotherapy research, which will serve as a reference and direction for future research.
Supplementation of Yupingfeng polysaccharides in low fishmeal diets enhances intestinal health through influencing the intestinal barrier, immunity, and microflora in Macrobrachium rosenbergii
Authors: Liu Mingyang , Sun Cunxin , Zhou Qunlan , Xu Pao , Wang Aimin , Zheng Xiaochuan , Liu Bo 
Published: November 2024

IntroductionThis study aimed to investigate the effects of a low-fishmeal diet (LF, substituting soybean meal for 40% fish meal) and the supplementation of 500 mg/kg and 1000 mg/kg Yu Ping Feng (YPF) polysaccharides on the growth performance, antioxidant enzyme activities, intestinal ultrastructure, non-specific immunity, and microbiota of Macrobrachium rosenbergii.MethodsThe study involved the administration of different diets to M. rosenbergii, including a control diet, a low-fishmeal diet (LF), and LF diets supplemented with 500 mg/kg and 1000 mg/kg YPF polysaccharides. Growth performance, antioxidant enzyme activities, intestinal ultrastructure, non-specific immunity, and microbiota were assessed.ResultsThe LF diet significantly reduced growth performance parameters compared to the control group. However, YPF supplementation notably improved these parameters, with the greatest improvement observed at a 1000 mg/kg dosage. Antioxidant enzyme activities (SOD, GSH-PX) were diminished in the LF group, accompanied by elevated MDA levels, whereas YPF supplementation restored these activities and reduced MDA levels. Ultrastructural analysis revealed that the LF diet caused intestinal villi detachment and peritrophic matrix (PM) shedding, which were alleviated by YPF. Gene expression related to PM formation (GS, CHS, EcPT) was downregulated in the LF group but significantly upregulated in the 1000P group. Non-specific immune gene expressions (IMD, Relish, IκBα) and enzyme activities (NO, iNOS) were suppressed in the LF group but enhanced by YPF supplementation. Microbial community analysis showed reduced diversity and altered composition in the LF group, with increased Proteobacteria and decreased Firmicutes, which were partially restored by YPF. Correlation analysis revealed that Lactobacillus and Chitinibacter play pivotal roles in regulating intestinal health. Lactobacillus exhibited a positive relationship with the intestinal PM and immune-related indicators, whereas Chitinibacter was negatively associated with these factors.DiscussionThese results highlight the adverse impacts of a low-fishmeal diet on the intestinal health of M. rosenbergii and demonstrate the beneficial effects of YPF polysaccharides in alleviating these negative consequences through various mechanisms, including improved growth performance, enhanced antioxidant enzyme activities, restored intestinal ultrastructure, and modulated immune responses. The findings suggest that YPF supplementation could be a valuable strategy for mitigating the negative effects of low-fishmeal diets in aaquaculture.
Glucosamine mitigates ischemia-reperfusion-induced acute kidney injury through anti-inflammatory mechanisms
Authors: Zhang Guangmin , Jin Shengxi , Fan Xinying , Qi Jingjing , Liu Jiane , Yin Shulan , Cao Yanjing , Du Yiping , Dong Xiaolei , Wang Zheng , Tan Xiaohua , Yan Shu 
Published: November 2024

ObjectiveAcute kidney injury (AKI), a syndrome with high morbidity and mortality worldwide, frequently arises from renal ischemia-reperfusion (I/R) injury, particularly in surgical contexts. Despite extensive research, effective therapies for both AKI and its progression to renal interstitial fibrosis remain elusive. This study investigates the potential therapeutic efficacy of glucosamine (GS), an endogenous amino sugar, in alleviating I/R-induced AKI.MethodsA murine I/R injury model was utilized to evaluate the protective effects of GS. Mice were treated with GS prior to I/R injury, and renal tissues were harvested for biochemical, histological, and molecular analyses. Key markers of oxidative stress, mitochondrial integrity, and endoplasmic reticulum (ER) stress were measured. Additionally, inflammatory responses in proximal convoluted tubular epithelial cells exposed to TPHP, an environmental toxin, were assessed in vitro.ResultsGS administration markedly reduced oxidative stress levels, preserved mitochondrial structure, and mitigated ER stress in renal tissues following I/R injury. Moreover, GS significantly attenuated TPHP-induced inflammatory responses in proximal tubular epithelial cells, suggesting a targeted anti-inflammatory action.ConclusionThese findings highlight glucosamine’s potential as a therapeutic agent for AKI, offering protection through the modulation of oxidative, mitochondrial, and inflammatory pathways. This study provides foundational evidence for GS as a promising candidate for AKI intervention and opens avenues for further exploration of glucosamine in kidney disease therapeutics.
Product perceptual design optimization model based on BP neural network
Authors: Yong Lei 
Published: November 2024

BackgroundUser reviews of online shopping platforms can truly reflect users’ feelings about the use of products. They have the advantages of large sample size, wide range and uniform distribution, and can help optimize the perceptual model of product design.MethodsThe web crawler crawls user comments, and TFIDF-SP quantifies them. The principal component analysis method selects the perceptual evaluation index, the morphological analysis method disassembles the product into several main structures, and the BP neural network constructs the perceptual optimization model.ResultsTaking the paint tray as an example, according to the trained BP neural network, the shape factor combination with the highest perceptual evaluation value is predicted. The experimental results verify the accuracy of the model.ConclusionThe model based on BP neural network has the ability to quickly and accurately combine the best form factors, improves the design efficiency of product design perceptual optimization, improves the rationality of product design, and provides a new idea for consumer demand market-oriented product design.
A bibliometric analysis of gene editing and amyotrophic lateral sclerosis (from 2004 to 2024)
Authors: Wan Hejia , Qian Wenli , Wei Bingqi , Tian Kaiyue , Chen Ziyi , Zhang Jiong , Chen Fang 
Published: November 2024

ObjectiveTo learn more about gene editing and ALS, and to provide a comprehensive view of gene editing for further treatment of amyotrophic lateral sclerosis.MethodsWe searched 1981 records from Web of Science core collection and Pubmed, Scopus, of which 1,292 records were obtained after exclusion. We then scientifically and metrologically analyzed these records for spatial and temporal distribution, author distribution, subject categories, subject distribution, references, and keywords using R, software CiteSpace and VOSviewer.ResultsOur analysis provides basic information about research in the field, suggests that the field has stabilized over the past decade, and identifies potential partners for interested researchers. Current research in this area is focused on inflammatory mechanisms, immune mechanisms, related diseases, and associated cytokines in ALS.ConclusionRNA Editing, Antisense Bligonucleotide, and Glycine Receptor are cutting-edge research topics in this field, which is undergoing rapid development. We hope that this work will provide new ideas for advancing the scientific research and clinical application of ALS.
Effect of motor process-related priming via repeated transcranial magnetic stimulation on embodiment perception during mirror visual feedback: a pilot study
Authors: Li Ying , Li Ping , Li Yixuan , Wang Jia , Shen Xinyao , Zhang Mingyong , Ding Li 
Published: November 2024

IntroductionNon-invasive brain stimulation has been combined with mirror visual feedback (MVF) as a priming strategy to enhance therapeutic efficacy. However, a superior combined effect is hindered by the lack of emphasis on MVF-relevant embodiment perception.ObjectiveThis study assessed the priming effect of repeated transcranial magnetic stimulation (TMS) over the primary motor cortex (M1) and dorsolateral prefrontal cortex (dlPFC) on embodiment perception during MVF.MethodsIn the experiment, 15 healthy participants were required to complete tasks using their left hand while keeping their right hand static behind a mirror. They first received excitatory TMS over the left M1 or dlPFC, or sham-TMS in random order during three trial rounds and then performed three subsequent motor tasks and two task-oriented evaluations during MVF in each trial. Latency time (LT), number of embodiment occurrences, embodiment questionnaire (EQ) score, and time required to complete the task-oriented activities were recorded.ResultsThe results showed that the LT of forearm rotation in the dlPFC-TMS round was shorter than that in the sham-TMS round, although a greater number of occurrences were obtained in both the M1-TMS and dlPFC-TMS rounds compared to the sham-TMS round within the three motor tasks, which suggested that TMS priming facilitated the elicitation of embodiment perception. The EQ results indicated strengthened embodiment perception after TMS priming, especially in the dlPFC-TMS round.ConclusionThis study provides evidence that TMS priming over motor process-related regions, specifically the dlPFC, contributes to eliciting and intensifying embodiment perception during MVF, which benefited from a superior MVF paradigm for improving rehabilitation outcomes.Clinical Trial RegistrationIdentifier ChiCTR2400089499 https://www.chictr.org.cn/showproj.html?proj=240385.
Knowledge graph and frontier trends in melanoma-associated ncRNAs: a bibliometric analysis from 2006 to 2023
Authors: Wang Ru , Zhu Xiao-yan , Wang Yi 
Published: November 2024

ObjectivesMalignant melanoma (MM) is a highly malignant skin tumor. Although research on non-coding RNAs (ncRNAs) of MM has advanced swiftly in recent years, no specific bibliometric analyses have been conducted on this topic. The present study aims to summarize the knowledge graphs and frontier trends and to provide new perspectives and direction of collaboration for researchers.MethodResearch data on melanoma and ncRNA published from January 1, 2006 to October 9, 2023 were retrieved and extracted from Web of Science. R Studio (Version 4.3.1), Scimago Graphica (Version 1.0.36), VOSviewer version (1.6.19), and Citespace (6.2.4R) were used to analyze the publications, countries, journals, institutions, authors, keywords, references, and other relevant data and to build collaboration network graphs and co-occurrence network graphs accordingly.ResultsA total of 1,222 articles were retrieved, involving 4,894 authors, 385 journals, 43,220 references, 2413 keywords, and 1,651 institutions in 47 countries. The average annual growth rate in the number of articles was 25.02% from 2006 to 2023; among all the journals, Plos One had the highest number of publications and citations, which are 42 publications and 2,228 citations, respectively. Chinese researchers were the most prolific publishers in this field, having published a total of 657 articles, among which 42 were published by Shanghai Jiao Tong University, which was the most productive institution. In recent years, the most explored keywords included long non-coding RNAs, immunotherapy, and exosm. According to the timeline chart of reference co-citation, “functional role” has been the most explored hotspot since 2015, and human cancer is a newly emerged hotspot after 2021.ConclusionThrough a bibliometric analysis, this study included all publications on ncRNAs and melanoma that were published in English from 2006 to 2023 in Web of Science to analyze the trends in the number of publications, international research focuses, and the direction of collaboration. The results of this study may provide information on knowledge graph, frontier trends and identify research topics in melanoma. More current research proved that ncRNA plays a crucial role in the biological behavior of melanoma including proliferation, invasion, metastasis, drug resistance, etc. With the development of research on ncRNA and melanoma, ncRNA may great potential in development of early diagnosis, targeted therapy and efficacy evaluation in the future. The results of this study also provide new perspectives and research partners for researchers in this field.
Kinetics of endothelin-1 and effect selective ETA antagonism on ETB activation: a mathematical modeling analysis
Authors: Hallow K. Melissa , Greasley Peter J. , Heerspink Hiddo J. L. , Yu Hongtao 
Published: November 2024

IntroductionEndothelin-1 (ET-1) regulates renal and vascular function, but the clinical utility of selective ETA receptor antagonists has been limited due to associated fluid retention. The mechanisms underlying fluid retention remain poorly understood but could be a consequence of changes in ET-1 binding to the unantagonized ETB receptor, either through increased ET-1 or non-selective ETB.MethodsA mathematical model of ET-1 kinetics was developed to quantify effects of ETA antagonist exposure and selectivity on concentrations of ET-1 and its complexes with ETA and ETB receptors. The model describes ET-1 production, tissue and plasma distribution, ETA and ETB receptor binding, and receptor-mediated clearance, and was calibrated and validated with human ET-1 infusion studies.ResultsThe model confirmed the significant role of ETB in ET-1 clearance. By varying both drug ETA selectivity (Kib/Kia) and concentration over a wide range, simulations predicted that while selective ETA antagonist (selectivity &gt;1) always decreased [ET1-ETA], the change in [ET1-ETB] was more complex. It increased up to 45% as drug concentrations approached and exceeded Kia, but the increase was diminished as drug concentration increased further and fell below baseline at high concentrations. The drug concentration required to cause a decrease in [ET1-ETB] was lower as ETA selectivity decreased.DiscussionThis is the first mechanistic mathematical model of ET-1 kinetics that describes receptor-mediated clearance, and the consequence of ETB blockade on ET-1 concentrations. It provides a useful tool that can coupled with experimental studies to quantitively understand and investigate this complex and dynamic system.