bluuebunny/crossref_metadata_2025_split huggingface dataset:
Predictors of Success of Phase II Pediatric Oncology Clinical Trials
Authors: Franshaw Laura , Tsoli Maria , Byrne Jennifer , Mayoh Chelsea , Sivarajasingam Siva , Norris Murray , Marshall Glenn M. , Ziegler David S. 
Published: February 2019

Abstract

Background
There are limited data to predict which novel childhood cancer therapies are likely to be successful. To help rectify this, we sought to identify the factors that impact the success of phase II clinical trials for pediatric malignancies.

Materials and Methods
We examined the impact of 24 preclinical and trial design variables for their influence on 132 phase II pediatric oncology clinical trials. Success was determined by an objective assessment of patient response, with data analyzed using Fisher's exact test, Pearson's chi-square test, and logistic regression models.

Results
Trials that evaluated patients with a single histological cancer type were more successful than those that assessed multiple different cancer types (68% vs. 47%, 27%, and 17% for 1, 2–3, 4–7, and 8+; p &lt; .005). Trials on liquid or extracranial solid tumors were more successful than central nervous system or combined trials (70%, 60%, 38%, and 24%; p &lt; .005), and trials of combination therapies were more successful than single agents (71% vs. 28%; p &lt; .005). Trials that added therapies to standard treatment backbones were more successful than trials testing novel therapies alone or those that incorporated novel agents (p &lt; .005), and trials initiated based on the results of adult studies were less likely to succeed (p &lt; .05). For 61% of trials (80/132), we were unable to locate any relevant preclinical findings to support the trial. When preclinical studies were carried out (52/132), there was no evidence that the conduct of any preclinical experiments made the trial more likely to succeed (p &lt; .005).

Conclusion
Phase II pediatric oncology clinical trials that examine a single cancer type and use combination therapies have the highest possibility of clinical success. Trials building upon a standard treatment regimen were also more successful. The conduct of preclinical experiments did not improve clinical success, emphasizing the need for a better understanding of the translational relevance of current preclinical testing paradigms.
Cost of Disease Progression in Patients with Chronic Lymphocytic Leukemia, Acute Myeloid Leukemia, and Non-Hodgkin's Lymphoma
Authors: Reyes Carolina , Engel-Nitz Nicole M. , DaCosta Byfield Stacey , Ravelo Arliene , Ogale Sarika , Bancroft Tim , Anderson Amy , Chen May , Matasar Matthew 
Published: February 2019

Abstract

Introduction
To reduce health care costs and improve care, payers and physician groups are switching to quality-based and episodic or bundled-care models. Disease progression and associated costs may affect these models, particularly if such programs do not account for differences in disease severity and progression risk within the cohort. This study estimated the incremental cost of disease progression in patients diagnosed with chronic lymphoid leukemia (CLL), acute myeloid leukemia (AML), and non-Hodgkin's lymphoma (NHL) and compared costs among patients with and without progression.

Methods
This was a retrospective study using U.S. administrative claims data from commercial and Medicare Advantage health care enrollees with evidence of CLL, AML, and NHL and systemic antineoplastic agent use from July 1, 2006 to August 31, 2014. Outcome measures included disease progression, 12-month health care costs, and 3-year cumulative predictive health care costs.

Results
Of 1,056 patients with CLL, 514 patients with AML, and 7,601 patients with NHL, 31.1% of patients with CLL, 63.8% of those with AML, and 36.9% of those with NHL had evidence of disease progression. Among patients with CLL and NHL, adjusted and unadjusted health care costs were significantly higher among progressors versus nonprogressors. Per-patient-per-month costs, accounting for variable follow-up time, were almost twice as high among progressors versus nonprogressors in patients with CLL, AML, and NHL. In each of the three cancer types, the longer disease progression was delayed, the lower the health care costs.

Conclusion
Progression of CLL, AML, and NHL was associated with higher health care costs over a 12-month period. Delaying cancer progression resulted in a substantial cost reduction in patients with all three cancer types.

Implications for Practice
Data on the rates and incremental health care costs of disease progression in patients with hematologic malignancies are lacking. This study estimated the incremental costs of disease progression in patients diagnosed with chronic lymphocytic leukemia, acute myeloid leukemia, and non-Hodgkin's lymphoma and compared health care costs in patients with and without evidence of disease progression in a real-world population. The data obtained in this study will assist future studies in quantifying the cost impact of decreased progression rates and will inform payers and physician groups about setting rates for episode and bundled payment programs.
Las nuevas tecnologías de aprendizaje y su participación en la exclusión social
Authors: Peña Lapeira Camilo 
Published: February 2019

Propósito: El propósito de este artículo es, precisamente, hacer un recorrido en torno a cómo se han presentado los diferentes cambios en la educación ante la presencia de las TICs, especialmente, para las personas que viven con alguna discapacidad. Descripción: Ante la aparición de las TICs, las sociedades del conocimiento han experimentado cambios en la forma en que dicho conocimiento es apropiado; ante la imposibilidad de acceder a dicho recurso o no capacitarse en el uso de ello se corre el riesgo de ser excluido y no ser parte de dichos sectores de la sociedad que abarcan desde las relaciones personales hasta las comerciales y laborales. Punto de vista: Se puede afirmar que en la medida en que se mejoren los procesos educativos de alfabetización digital para conocimiento y uso de las TICs, se logrará reducir la brecha digital. Conclusiones: La educación en especial tiene el reto de tratar de reducir la brecha digital existente para asimismo reducir la brecha social que ésta ha generado, haciendo uso de recursos y procesos como los de alfabetización digital impulsados por los diferentes gobiernos que han destinado recursos en la medida de sus posibilidades.
A randomized cross over trial of oral nifedipine and intravenous labetalol in pregnant women with severe pre-eclampsia and eclampsia
Authors: Krishna Kirtan , Shailaja N. , Bhat B. Shyamasundara , Krishna L. , . Namrata 
Published: February 2019

Background: The aim of treatment of severe pre-eclampsia and eclampsia is to quickly bring about a smooth reduction in blood pressure to levels that are safe for both mother and baby but avoiding any sudden drops. There are not many studies comparing nifedipine and labetalol for this purpose. Authors conducted this study with the aim of comparing their efficacy in reducing maternal blood pressure.Methods: It was a cross over trial with 30 patients in each group conducted at a tertiary care hospital. 60 pregnant women were randomized to receive nifedipine (20mg loading dose followed by 10 mg tablet, orally, up to maximum of five doses) or intravenous labetalol (in an escalating dose regimen of 20, 40, 80, 80 and 80 mg) every 20 minutes until the target blood pressure of 150/100 mmHg was achieved. Crossover treatment was affected if the initial treatment regimen was unsuccessful after 20 min of the last dose of the drug in the respective groups.Results: The mean time to achieve the target blood pressure was 32.0 ±18.64 minutes (mean ± SD) in nifedipine group as compared with 37.04 ± 16.36 minutes in those receiving labetalol (P = .002). In the nifedipine group 63.3% required only one dose compared to 36.6% in the labetalol group. Only two women in the nifedipine group required maximum number of doses that is five doses. Cross over treatment was required by 10% of patients in the labetalol group and none in the nifedipine group.Conclusions: This study shows that oral nifedipine is more effective than intravenous labetalol in rapid control of hypertension in severe pre-eclampsia and eclampsia.
A study of abnormal semen parameters in infertile couples in Assam, India
Authors: Juneja Parija , Phukan Pranay K. , Changmai Debojit 
Published: February 2019

Background: The importance of male factor contribution to infertility is well recognised. Semen analysis is an indispensable diagnostic tool in the evaluation of the male partners of infertile couples. Aim and objective of the study was conducted to determine the abnormalities in semen among male partners in infertile couples.Methods: Detailed history, examination and semen analysis was done. Semen samples were analysed for volume, viscosity, sperm concentration, motility, and morphology, according to WHO guidelines.Results: This study, done at a tertiary care center in north eastern India has demonstrated that abnormal semen quality is a major factor contributing to infertility in couples. Total number of participants were 94. Most of the male partners i.e. 65.96%, who came for infertility evaluation were between 30-39 years of age with 56.38% participants having abnormal semen parameters. The most common abnormality found was asthenozoospermia seen in 35.11% of cases followed by oligozoospermia seen in 25.53% of cases. Teratozoospermia and azoospermia were seen in 7.45% and 4.26% of cases respectively.Conclusions: Males contribute towards infertility in couples significantly. Abnormal semen pattern is a common cause. More research is needed to render more valuable and significant results regarding male infertility.
Training of maternal health care providers in newer modalities of management of post-partum haemorrhage
Authors: Bhardwaj Samita , Raut Sonal , Bangal Vidyadhar B. 
Published: February 2019

Background: Postpartum haemorrhage (PPH) is a life-threatening complication, that occurs suddenly and unexpectedly. Institutional delivery by skilled birth attendant who are trained in active management of third stage of labour and those who can use of Uterine Balloon Tamponade and Non-pneumatic anti shock garment can reduce incidence and morbidity related to PPH. The objective of the paper was to share the experiences of the training programmes held for maternal health care workers in the newer modalities of PPH management.Methods: During one and a half year period, 32 Continuation of Medical Education (CME) programmes, with the theme of “Managing Obstetric Emergencies and Obstetric Trauma”, covering important topics related to high risk pregnancies like Hypertension, Eclampsia ,Anaemia and Haemorrhage at 32 health institutions, spread over 11 states and 2 union territories in India, were conducted .In addition,42 hands on workshops at various health facilities were conducted with training of more than 2575 maternal health care providers.Results: The pre and post test scores revealed that 95 percent of the maternal health care providers were unaware about the use of Uterine Balloon Tamponade (Bakri balloon) in PPH and Non-pneumatic anti shock garment (NASG). Seventy percent were unaware about the proper sequence of steps of active management of third stage of labour. Training programmes helped to improve the knowledge, whereas hands on workshop, helped in skill development of the health care providers. The participants expressed great satisfaction regarding the knowledge and skills they acquired through training programme on management of post-partum haemorrhage. They gave positive feedback about the quality, contents and conduct of training programme.Conclusions: There is need for refresher training of maternal health care providers in newer modalities like AMTSL, NASG and Bakri balloon, which have potential to save lives.
Study of knowledge, attitude, practices regarding PPIUCD among antenatal women at a tertiary care centre in Northern India
Authors: Asnani Mona , Agarwal Anjoo , Singh Renu 
Published: February 2019

Background: PPIUCD has been introduced in the national family welfare program since March 2010 in several states. AN IUCD can be inserted in 48 hours postpartum, referred to here as postpartum intrauterine contraceptive device. This study was done to assess the Knowledge, attitude and practice of postpartum Intrauterine contraceptive device in antenatal patients at a tertiary care centre in Northern India.Methods: This is a questionnaire based cross sectional observational study including 350 antenatal women attending antenatal OPD over a period of 6 months.Results: Out of these 350 women, 126 women (36%) had knowledge of PPIUCD. only 30 % of women had previous knowledge about PPIUCD however only 10 % of women practiced it in the past. After appropriate counselling 18% of women agreed for insertion of PPIUCD after this delivery.Conclusions: The study concludes that the antenatal women had poor knowledge regarding PPIUCD. Practices were even worse. This might be attributed to low education , refusal by family especially male partner, and religious beliefs. But once appropriate knowledge and information is provided, attitude gradually changes.
Fatal outcome in acute fatty liver of pregnancy and review of literature
Authors: Rani Reena , Rathore Asmita M. , Bhasin Sangeeta 
Published: February 2019

Acute fatty liver of pregnancy (AFLP) is an uncommon life-threatening disorder of pregnancy seen commonly in third trimester. When not diagnosed at right time it can lead to hepatic failure, encephalopathy, coagulopathy, maternal and fetal mortality. The clinical symptoms and signs are nonspecific, and it needs to be identified early in order to prevent poor outcome. The gold standard for diagnosis of AFLP is liver biopsy, which is difficult in an acute setting and in abnormal coagulation profile hence the diagnosis is usually based on clinical criteria Early termination of pregnancy and good intensive care support are the mainstay of management. The authors here presented a case report where even early delivery and good critical care failed to prevent maternal mortality. Review of literature regarding etiopathogenesis, management and recurrences of AFLP are also discussed.
Wolf Parkinson White sendromu (WPW) ablasyonu yapılan hastaların özellikleri: Tek merkez vaka serisi
Authors: KANAT Selcuk , TÜTÜNCÜ Ahmet 
Published: February 2019

Amaç:
Aksesuar yol varlığı ile oluşan atriyoventriküler reentran taşikardiler (AVRT)
paroksismal supraventriküler taşikardilerin yaklaşık dörtte birini oluşturur.
Bizim retrospektif çalışmamızın amacı katater ablasyon işlemi yapılan yüksek
volümlü bir merkezde, AVRT ablasyon yapılan
hastaların demografik özellikleri, etiyolojik faktörler ve komplikasyon
oranları hakkında bilgi vermektir. Gereç ve Yöntemler:
Hastanemizin kardiyoloji kliniğinde Ocak 2014 ve Ocak 2018 yılları arasında SVT ablasyonu uygulanan 1107 hasta tarandı ve katater
ablasyon yapılmış 232 WPW ’li hasta çalışmaya dahil edildi. Bu hastalar
demografik özellikleri, etiyolojik faktörleri, aksesuar yol lokalizasyonları,
işlem başarısı ve komplikasyon gelişimi açısından değerlendirilmiştir. Bulgular:
Hastaların yaş ortalaması 38 ±16,1 olup ve kadın cinsiyet oranı %37.1 dir. En
sık görülen lokalizasyonun sol aksesuar kaynaklı yolak olduğu görüldü(%53,1).
Tüm lokalizasyonlar için akut dönemde işlem başarısı %93,1 saptandı. Tüm
hastalarda karşılaşılan komplikasyon oranı % 3,3 iken, en sık karşılaşılan
komplikasyon girişim yeri hematomu olarak karşımıza çıkmıştır(% 2,1).

Tartışma: Tüm
yaş gruplarını etkileyebilen ve yaşam kalitesini oldukça kötüleştirebilen bir
hastalık grubu supraventriküler taşikardiler (SVT) dir. Bu grubun ikinci
sıklıkta görülen üyesi AVRT’nin bilinen küratif tedavisi radyofrekans katater
(RF) ablasyondur. Ablasyon tedavisi yapan hekim sayısı ve işlemin yapıldığı
merkez sayısı giderek artış göstermektedir. Özellikle gelişebilecek komplikasyonlar
açısından dikkat çekmek amaçlı AVRT ablasyon tecrübelerimiz bu çalışma ile sunulmuştur.
Effect of lethal yellow (AY) mutation and photoperiod alterations on mouse behavior
Authors: Bazhenova E. Y. , Fursenko D. V. , Khotskin N. V. , Sorokin I. E. , Kulikov A. V. 
Published: February 2019

Decrease in natural illumination in fall/winter months causes depressive-like seasonal affective disorders in vulnerable individuals. Obesity is another risk factor of depression. The lethal yellow (AY) mutation causes ectopic expression of agouti protein in the brain. Mice heterozygous for AY mutation (AY/a) are obese compared to their wild-type littermates (a/a). The main aims of the study were to investigate the effects of AY mutation, photoperiod and the interaction between these factors on daily activity dynamics, feeding, locomotor and exploratory activities, anxiety-related and depressive-like behaviors in mild stress condition. Six weeks old mouse males of AY/a and a/a lines were divided into four groups eight animals each and exposed to long- (14 h light and 10 h darkness) or short- (4 h light and 20 h darkness) day conditions for 28 days. Then the behavior of these mice was successively investigated in the home cage, open field, elevated plus-maze and forced swim tests. We did not observed any effect of AY mutation on the general activity, water and food consumption in the home cage; locomotion and exploration in the open field test; anxiety-related behavior in the open field and elevated plus-maze tests. At the same time, AY mutation increased depressive-like immobility time in the forced swim test (F1.28 = 20.03, p = 0.00012). Shortday conditions decreased nocturnal activity in the home cage, as well as locomotion (F1.28 = 16.33, p = 0.0004) and exploration (F1.28 = 16.24, p < 0.0004) in the open field test. Moreover, short-day exposition decreased time spent in the center of the open field (F1.28 = 6.57, p = 0.016) and in the open arms of the elevated plus-maze (F1.28 = 12.08, p = 0.0017) tests and increased immobility time in the forced swim test (F1.28 = 9.95, p = 0.0038). However, no effect of the interaction between AY mutation and photoperiod on immobility time in the forced swim test was observed. Therefore, short-day photoperiod and AY mutation increased depressive-like behavior in the forced swim test by means of different mechanisms.
Label Identification And Bacteriological Quality Assessment Of Sambel Pecel (Peanuts Dressing Sauce) Product In Madiun City
Authors: Fadhilah Richa Dwi 
Published: February 2019

Food product requirements before distribution to consumers are including of the proper food labeling, and zero count of Eschericia coli bacteria. This study aims to identify the labeling process and bacteriological examination (Eschericia coli) on javanese peanut dressing sauce (sambel pecel) product in Madiun city. The research is an observational research whereas data is analyzeddescriptively by cross sectional study design. This study used observations andinterview in obtaining data regarding the completeness of labeling. bacteriological examination (Eschericia coli) was performed by Environmental Health Laboratory of Health Polytechnic of Ministry of Health Surabaya for the total sample of 15 sambel pecel products. All of sambel pecel products in Madiun are without a complete label andwere inconsistent with the standards of the Governmental Regulations of food label and advertisement regulation.Each product is required to implement eleven label component such as product name, composition, net weight, expiration date, name and address of producer, label of halal, and consument information for disability occurs. Five out of 15 products were positively contain Eschericia coli bacteria while the products based on regulation about food, that it must be 0 (zero). Thus it can be suggested for Trade and Industry Service of Madiun toimplement stringent selection and monitoring process before distribute the product to general population.
Validasi Metode Bioanalisis Vankomisin HCl dalam Spiked-plasma Manusia Menggunakan KCKT-UV untuk Aplikasi PKOD
Authors: Wibowo Ari , Maulidina Damas Inggil , Fitri Wahyuni Shalatan , Ningrum Vitarani 
Published: February 2019

As the first-line antibiotic for the treatment of infections caused by methicillin-resistant Staphylococcus aureus (MRSA), vancomycin has a narrow therapeutic index with high pharmacokinetic variability. Therefore, it is deemed necessary to examine its concentration in the blood as a strategy to monitor the fulfillment of therapeutic levels in patients receiving vancomycin. This study aimed to validate vancomycin bioanalysis in spiked-human plasma for the applications of therapeutic drug monitoring (TDM).
PENGARUH KUALITAS PRODUK, PERSEPSI HARGA, DAN CITRA MEREK TERHADAP KEPUASAN DAN LOYALITAS PELANGGAN BETON SIAP PAKAI HOLCIM DI JAKARTA
Authors: Budiastari Sita 
Published: February 2019

ABSTRAK

Tujuan penelitian ini adalah untuk mengetahui gambaran atas pengaruh kualitas produk, persepsi harga dan citra merek terhadap kepuasan dan loyalitas pelanggan beton siap pakai di Jakarta. Penelitian ini adalah penelitian kuantitatif dengan metode deskriptif dan kausal yang di lakukan di Holcim Beton pada tahun 2013 dengan sampel sebanyak 100 pelanggan di Jakarta dan sekitarnya pada segmen Industrial dan komersial proyek. Pengumpulan data responden dengan kuesioner dan dianalis dengan menggunakan analisa jalur (path analysis) dengan bantuan program SPSS versi 20.0. terhadap kepuasan pelanggan (2) Persepsi Harga berpengaruh positif dan signifikan tehadap kepuasan pelanggan, (3) Citra Merek tidan memiliki pengaruh terhadap Hasil penelitian disimpulkan bahwa (1) Kualitas Produk tidak berpengaruh kepuasan pelanggan, (4) semua variabel bebas, kualitas produk, Persepsi harga dan Citra Merek berpengaruhi positif dan signifikan terhadap variabel terikat Kepuasan Pelanggan, dengan nilai determinasi sebesar 50 %, sedangkan 50% lainnya di pengaruhi oleh variabel lainnya (5) Kualitas Produk berpengaruh dan signifikan terhadap Loyalitas Pelanggan melalui kepuasan pelanggan, (6) Persepsi Harga tidak berpengaruh terhadap loyalitas melalui kepuasan pelanggan, (7) Citra Merek berpengaruh dan siginikan terhadap loyalitas melalui kepuasan pelanggan, (8) Semua varibel bebas kualitas produk, persepsi harga dan citra merek secara bersama-sama berpengaruh dan signifikan terhadap loyalitas melalui kepuasan pelanggan, dengan nilai determinasi sebesar 77.4 % dan 22.6 % lainnya di pengaruhi oleh faktor lainnya.

Hasil temuan mengarahkan untuk merekomendasikan agar Holcim meningkatkan kualitas produk, persepsi harga dan citra merek untuk meningkatkan loyalitas melalui kepuasan pelanggan. Hal ini juga merekomendasikan kepada Holcim untuk meneningkatakan layanan dan informasi kepada pelanggan guna meningkatkan kepuasan dan loyalitas pelanggannya.

Kata kunci: kualitas produk, persepsi harga,citra merek, kepuasan, loyalitas pelanggan, beton siap pakai Holcim di Jakarta.
Pengaruh Persepsi Public Relation, Kepercayaan dan Citra Merek terhadap Loyalitas Pelanggan
Authors: Putri Birgitta Amanda , Hidayati Tetra 
Published: February 2019

Abstrak: Penelitian ini dilakukan untuk menguji pengaruh persepsi PR Kepercayaan dan Citra Merek terhadap loyalitas pelanggan. Penelitian ini menggunakan persamaan regresi berganda dimana data didapat dari konsumen atau pelanggan Brow Studio (perusahaan sulam alis milik Anggie Rassly). Berdasarkan kriteria yang telah ditentukan, peneliti mendapatkan 225 data yang dianalisis dengan menggunakan SPSS sebagai software pengolah datanya. Hasil penelitian ini menunjukkan bahwa persepsi PR, kepercayaan dan citra merek berpengaruh signifikan terhadap loyalitas pelanggan.
Kata kunci: persepsi PR, Kepercayaan, citra merek, loyalitas pelanggan