bluuebunny/crossref_metadata_2025_split huggingface dataset:
PENGARUH LINGKUNGAN KERJA DAN MOTIVASI KERJA TERHADAP KINERJA PEGAWAI UNIT PELAKSANA TEKNIS PENDIDIKAN KECAMATAN GUNUNG PUTERI
Authors: Laela Siti , Sardi Sardi 
Published: January 2019

Lingkungan Kerja dan Motivasi Kerja adalah dua dari beberapa faktor yang cukup besar dalam mempengaruhi Kinerja Pegawai.Untuk membuktikan pengaruh kedua faktor tersebut maka dilakukan penelitian ini dengan tujuan untuk mwngetahui pengaruh lingkungan kerja dan motivasi terhadap kinerja pegawai Unit Pelaksana Teknis (UPTP) II Kecamatan Gunungputri.Penelitian dilakukan di UPTP II Kecamatan Gunungputri dengan mengambil 74 pegawai sebagai sampel penelitian yang dihitung dengan rumus Croncbachâ€™s Alpha dari total populasi 74 pegawai pada margin error 5%. Pengambilan data dengan instrument kuesionerÂ tertutup dengan lima skala penilaian dari sangat tidak setuju sampai dengan sangat setuju Penelitian dilakukan secara kuantitatif yaitu dengan mendeskripsikan data penelitian dan melakukan analisis inferensi. Analisis, regresi sederhana dan ganda digunakan sebagai alat analisis, sedangkan pengajuan hipotesis dilakukan dengan uji-t dan uji-F.Penelitian menghasilkan tiga temuan utama sesuai dengan hipotesis yang diajukan, yaitu: 1) Lingkungan kerja memiliki pengaruh positif terhadap kinerja pegawai; 2) Motivasi kerja memiliki pengaruh positif terhadap kinerja pegawai;Â 3) Lingkungan kerja dan motivasi kerja memiliki pengaruh positif terhadap kinerja pegawai.Berdasarkan hasil temuan tersebut maka untuk meningkatkan kinerja pegawai disarankan agar dilakukan upaya memperbaiki lingkungan kerja dan motivasi kerja pegawai.Â Kata kunci: Lingkungan Kerja, Motivasi Kerja, Kinerja Pegawai.
Perancangan Pengaplikasian Data Penjualan Beton Pada Toko Aneka Beton Di Nagari Lintau Buo Tanah Datar Dengan Menggunakan Bahasa Pemogramman Php Dan Mysql
Authors: Ramadhanu Agung - 
Published: January 2019

Perancangan pengaplikasianÂ data penjualan beton pada toko aneka beton ini bertujuan untuk mengoptimalkan dan mempermudah dalam menginputkan data penjualan beton agar terbentuknya laporan penjualan yang akuratÂ dan terstruktur. Tugas akhir ini bertujuan untuk membangun sebuah sistem perancangan pengaplikasian data penjualan, Sistem perancangan dalam pembuatan aplikasi pada toko aneka beton ini dikembangkan dengan menggunakan beberapa software yakni xampp, notepad++, Server yang merupakan gabungan dari PHP dan MySQL
La baisse de l'impôt sur les sociétés et la valeur des entreprises
Authors: Meunier François 
Published: January 2019

L'article analyse les effets pour les entreprises de cette tendance majeure observée depuis deux ou trois décennies : la baisse continue des taux d'impôt sur les sociétés. Contrairement à l'opinion courante, baisser le taux d'IS ne favorise pas nécessairement les actionnaires et l'économie fiscale est loin de demeurer dans les bilans des entreprises. La raison en est que l'IS a les caractéristiques d'un impôt largement neutre : son niveau influe assez peu sur le rendement du capital et le comportement des entreprises en matière de production et d'emploi. Comment penser autrement que les grandes économies aient pu prospérer dans l'après-guerre avec des taux d'impôt de l'ordre de 50 % ? L'article montre que l'ouverture croissante des frontières et des marchés de capitaux change fortement la donne, et fait perdre une grande part de la neutralité de l'IS. Baisser l'IS profite en une fois aux entreprises du pays qui enclenche la baisse, avant que l'impôt retrouve sa (quasi-)neutralité, sous l'effet de la réponse stratégique des autres pays. C'est ce qui alimente la course, au final assez vaine, mais très déstabilisante pour les finances publiques, à la baisse des taux d'impôt. Classification JEL : G32, H25, H32.
Les banques et les paradis fiscaux
Authors: Barake Mona , Capelle-Blancard Gunther , Lé Mathias 
Published: January 2019

L'affaire UBS en 2008, Offshore Leaks en 2013, Lux Leaks en 2014, Swiss Leaks en 2015, Panama Papers et Football Leaks en 2016, Paradise Papers en 2017. Depuis la crise financière mondiale, scandales après scandales, les paradis fiscaux sont sous pression. Longtemps considéré comme marginal par les économistes, le sujet fait l'objet de nombreux travaux académiques ces dernières années. Les études confirment le poids massif de ces micro-États (près de 10 000 milliards d'actifs enregistrés, près de la moitié des investissements directs à l'étranger), leur impact très significatif sur l'imposition effective des multinationales, le manque à gagner fiscal pour les autres États (plusieurs centaines de milliards), ainsi que le rôle clé joué par les intermédiaires financiers. La BRI publie depuis le milieu des années 1970 des données sur les encours bancaires transfrontaliers qui montrent leur importance : les paradis fiscaux hébergent près de 20 % des encours transfrontaliers lorsqu'on considère les positions non consolidées. Par ailleurs, l'Union européenne a réussi à imposer à ses banques qu'elles rendent publiques depuis 2016 leurs activités dans tous les pays, y compris dans les paradis fiscaux ( Country-by-Country Reporting , CbCR). Il ressort de ces données que les paradis fiscaux représentent, pour les banques européennes, 18 % de leur chiffre d'affaires et 29 % de leur profit à l'étranger, tandis qu'elles emploient seulement 9 % de leur main-d'œuvre à l'étranger. Classification JEL : F23, G20, G28, H25, H26.
De quelle poétesse Marc est-il le nom ? Le premier Évangile est-il l’œuvre d’une femme ?
Authors: Vouga François 
Published: January 2019

Ne pourrait-on pas penser, avec de bonnes raisons, que la composition de l’Évangile de Marc, et donc la création du genre littéraire de l’Évangile, soit l’œuvre d’une femme ? François Vouga considère et évalue le regard intime porté dans la narration sur les personnages féminins. Aux Douze et aux compagnons de Jésus, désignés comme ses élèves et désorientés par son absence, l’Évangile selon Marc oppose plusieurs figures de femmes indépendantes et autonomes. Elles avaient pris elles-mêmes l’initiative de l’accueillir en Galilée et de l’accompagner à Jérusalem. Puis aux moments décisifs de la Passion, de la mort et de l’annonce de Pâques, elles assurent leur relève. Ne serait-ce pas l’indice d’une signature indirecte ?
Simulation ou fuite dans la maladie ?
Authors: de Mijolla-Mellor Sophie 
Published: January 2019

Le procès contre la « faradisation » des soldats pour les contraindre à retourner au front au cours de la Première Guerre mondiale pose tout d’abord une question éthique tant pour le soldat que pour le médecin. Mais la question est aussi juridique, puisqu’il s’agit d’un procès et médicale pour savoir quel est le traitement le plus approprié dans ce type de cas. Quant à la question du diagnostic préalable, c’est celle qui continue de nous intéresser aujourd’hui. Elle en recouvre une autre, d’ordre étiologique, soit le débat qui n’a pas cessé entre l’organique et le psychogène.
Influence of Preoperative Astigmatism Type and Magnitude on the Effectiveness of SMILE Correction
Authors: Pérez-Izquierdo Ricardo , Rodríguez-Vallejo Manuel , Matamoros Alicia , Martínez Javier , Garzón Nuria , Poyales Francisco , Fernández Joaquín 
Published: January 2019

PURPOSE:
To assess the effectiveness of small incision lenticule extraction (SMILE) as a function of the astigmatism level and type.

METHODS:
A total of 102 right eyes were included in this study. Refractive astigmatism and corneal astigmatism measured with Scheimpflug technology were retrieved from the preoperative visit and the 3-month follow-up visit. Patients were split into three groups according to the preoperative refractive astigmatism (0.50, 0.75 to 1.25, and 1.50 diopters [D] or greater) and the effectiveness among each group was evaluated according to the with-the-rule (WTR), against-the-rule (ATR), and oblique classifications. The standard Alpins method was used for the analysis.

RESULTS:
Resultant astigmatism was not associated with its preoperative classification when the total sample was considered, but a significant association emerged between the presence of resultant astigmatism and its preoperative classification in the 1.50 D or greater group. The magnitude of error was significantly lower in the WTR (median: −0.30 D) than in the oblique and ATR astigmatism groups, resulting in a coefficient of adjustment of 1.13 for WTR astigmatism of 1.50 D or greater but not for the other types.

CONCLUSIONS:
Astigmatism correction with SMILE is predictable for astigmatism lower than 1.50 D without the need to apply a correction. However, higher undercorrection is present in WTR astigmatism of 1.50 D or greater.

[
J Refract Surg
. 2019;35(1):40–47.]
Anatomical and Functional Retinal Complications of Combined Sofosbuvir and Ribavirin Therapy in Patients With Chronic Hepatitis C Virus
Authors: Elgouhary Sameh Mohamed , Said-Ahmed Khaled Elgonemy , Mowafy Mahmoud Ali 
Published: January 2019

BACKGROUND AND OBJECTIVE:
To evaluate the anatomical and functional retinal complications of combined sofosbuvir and ribavirin therapy in patients with chronic hepatitis C virus (HCV).

PATIENTS AND METHODS:
Three hundred patients with chronic HCV were recruited for this prospective, observational study from the National Liver Institute of Menoufia University from November 2015 to September 2017. Ophthalmic examination and follow-up were performed in the outpatient clinic of the Ophthalmology Department at Menoufia University. All patients received the same regimen (sofosbuvir and ribavirin) for 6 months. Patients were followed up during the period of treatment (6 months) and for 6 months after treatment completion. Complete ophthalmic examination, fundus fluorescein angiography (FFA) (to detect retinal ischemia), optical coherence tomography (OCT) (to detect retinal nerve fiber layer [RNFL] thickness and central macular thickening), and electroretinogram (ERG) (to detect rod and cone functions) tests were performed before and after treatment completion.

RESULTS:
The mean age of the patients was 46.17 years ± 11.38 years (range: 20 years to 60 years). The study included 138 men (46%) and 162 women (54%). During follow-up, there were no signs of retinopathy or optic nerve affection. There were also no signs of retinal ischemia (by FFA), RNFL affection, macular edema (by OCT), or rod or cone affection (by ERG).

CONCLUSION:
Combined treatment (sofosbuvir and ribavirin) may be safe without causing anatomical or functional retinal complications.

[
Ophthalmic Surg Lasers Imaging Retina
. 2019;50:39–42.]
Cutting Edge: ICOS-Deficient Regulatory T Cells Display Normal Induction of Il10 but Readily Downregulate Expression of Foxp3
Authors: Landuyt Ashley E. , Klocke Barbara J. , Colvin Tyler B. , Schoeb Trenton R. , Maynard Craig L. 
Published: January 2019

Abstract
The ICOS pathway has been implicated in the development and functions of regulatory T (Treg) cells, including those producing IL-10. Treg cell–derived IL-10 is indispensable for the establishment and maintenance of intestinal immune homeostasis. We examined the possible involvement of the ICOS pathway in the accumulation of murine colonic Foxp3- and/or IL-10–expressing cells. We show that ICOS deficiency does not impair induction of IL-10 by intestinal CD4 T cells but, instead, triggers substantial reductions in gut-resident and peripherally derived Foxp3+ Treg cells. ICOS deficiency is associated with reduced demethylation of Foxp3 CNS2 and enhanced loss of Foxp3. This instability significantly limits the ability of ICOS-deficient Treg cells to reverse ongoing inflammation. Collectively, our results identify a novel role for ICOS costimulation in imprinting the functional stability of Foxp3 that is required for the retention of full Treg cell function in the periphery.
Strategic priorities for cultivating commitment amongst academic staff: The militating effect of workplace spirituality
Authors: Kokt Desere , Palmer Esther P. 
Published: January 2019

Orientation: Organisational commitment remains an ongoing concern for organisations, especially universities that often struggle to retain academic staff. Universities cannot operate or fulfil their mandate to society without the critical competencies of academic staff.Research purpose: This investigation focused on workplace spirituality as a militating factor in enhancing the commitment of academic staff.Motivation for the study: As organisational commitment remains a challenge for universities, this article contributes to a theoretical and empirical understanding of the militating influence of workplace spirituality. The study is underpinned by social learning theory and proposes strategic priorities to universities – informed by an empirical study conducted amongst academic staff members at a South African university.Research approach/design and method: The study employed a quantitative research approach and a structured questionnaire was administered to 285 academic staff members (ranging from junior lecturers to professors) of a South African university. The research design was a survey and, as a single university formed part of the study, regression analysis was used to establish the relationship between workplace spirituality and organisational commitment.Main findings: The empirical findings showed a strong linear relationship between workplace spirituality and organisational commitment. A regression formula was developed to statistically calculate the commitment score of individuals.Practical/managerial implications: The study proposed strategic priorities that may be useful to university management and human resource practitioners to cultivate increased commitment amongst academic staff.Contribution/value-add: The study contributed empirical evidence of the militating effect of workplace spirituality on organisational commitment, implying that workplace spirituality is a predictor for organisational commitment.
Sexual functions of female patients with chronic liver disease from two centers in Nigeria
Authors: Adekanle Olusegun , Olowookere Samuel , Ijarotimi Oluwasegun , Ndububa Dennis , Ayodeji Oladele 
Published: January 2019

Abstract
Background: Chronic liver disease (CLD) is a disease with significant morbidity and mortality in Nigeria. This study assessed the sexual functions of women with chronic hepatitis B infection (CHB), liver cirrhosis (LC), and hepatocellular carcinoma (HCC) designated as cases and normal women as controls. Methods: A prospective, comparative, case–control study of CHB, LC, HCC, and controls. Consenting cases and controls completed a self-administered Female Sexual Function Questionnaire (FSFI). Bio-data was obtained for all participants and cases were graded using the Child–Turcotte–Pugh scores (CTP). Data obtained were entered into SPSS version 20 and analyzed using descriptive and inferential statistics. Results: A total of 176 women completed the study, comprising 88 cases and 88 controls. Mean age (standard deviation) was 39.5 + 8.5 years and 40.5 + 8.2 years for cases and controls, respectively. Cases comprised CHB – 46, LC – 25, and HCC – 17, and their CTP classes were CTP A, 54; CTP B, 22; and CTP C, 12. The FSFI scores for CHB compared with controls were not statistically significant in all domains of the FSFI. The FSFI scores for LC and HCC in all domains were statistically significant compared with controls. Total mean FSFI scores for cases in CTP Class C showed sexual dysfunction, where 13.6% of CLD and 6.8% of all participants had sexual dysfunction and none among the controls. Conclusions: Females with advanced CLD had sexual dysfunction. Sexual concerns of females with CLD should be inquired for and treated.
Impact of chronic stress on cardiovascular system: Libyan conflict health perspective. Part one: Types of chronic stresses
Authors: Elhwuegi Abdalla , Teebar Lamis 
Published: January 2019

AbstractRecent studies have provided clear and convincing evidence that chronic stress contributes significantly to the pathogenesis and expression of cardiovascular diseases (CVDs). This bibliography is a systematic review on the impact of chronic stress on the cardiovascular system with a special reflection on the Libyan conflict. It is divided into two parts, Part 1 deals with types of chronic stresses, while Part 2 deals with mechanisms involved in chronic stress and their treatments. Medline/PubMed, Google Scholar, and Scopus databases were used to search for peer-reviewed papers dealing with the review theme. Stress can be classified into acute stress and chronic stress. Chronic stress can stem from underlying factors such as economic stress, social isolation stress, posttraumatic stress, and job strain stress. Economic stress is emerging as an important determinant of perceived health where different studies have found an inverse trend between risk factor burden and cardiovascular disease prevalence in urban and rural communities in high-, middle-, and low-income regions. Social stress is another factor that has been reported to be associated with a 2–3 fold increase in the incidence of CVD. Moreover, multiple studies have shown that patients suffering from posttraumatic stress disorder have increased resting heart rate, increased startle reaction, and increased blood pressure as responses to traumatic events. CVD is one of the health outcomes whose links with work stress have been well established based on numerous prospective studies.
Immune checkpoint inhibitors: Real-world experience from India in advanced solid cancers that have progressed on chemotherapy
Authors: Gupta Vineet Govinda , Rangaraju Ranga Rao , Abbas Waseem , Bajpai Peush , Khetrapal Ruchika 
Published: January 2019

Abstract
Context: The immune checkpoint inhibitors (ICIs) nivolumab and pembrolizumab have shown dramatic efficacy with low toxicity in international studies of advanced solid cancers. No published Indian experience with ICIs exist other than isolated case reports. Aims: The aim of this study is to evaluate real-world data about the efficacy and toxicity of ICIs in advanced solid cancers among Indian patients who have progressed on one or more prior lines of chemotherapy. Materials and Methods: All patients with advanced solid cancers who received ICIs after the failure of chemotherapy at our center were retrospectively assessed. Information about efficacy and toxicity was collected and analyzed. Results: The present study included 24 patients who had received ICIs for indications including non-small cell lung, bladder, head and neck, gastrointestinal, and unknown primary cancer. Patients had received a median of two prior lines of chemotherapy (range 1–5). Grade III or higher toxicity was seen in 8% of patients. Clinical benefit at 3 months was realized in 33% of evaluable patients. Twenty-six percentages of evaluable patients achieved a response, including one patient who achieved a complete response that is ongoing at 18 months. Median progression-free survival was 3 months, and median overall survival was 8 months at a median follow-up of 10 months. Among patients who achieved clinical benefit, the majority (84%) have an ongoing response at the time of data cutoff. Conclusions: Efficacy and toxicity of ICIs in the Indian population are similar to the experience seen in large international cohorts, and Indian oncologists may feel reassured using these agents in similar settings.
Primary gastrointestinal diffuse large B-cell lymphoma: A prospective study from South India
Authors: Suresh Babu , Asati Vikas , Lakshmaiah K. C. , Babu Govind , Lokanatha D. , Jacob Linu Abraham , Lokesh K. N. , Rudresh A. H. , Rajeev L. K. , Smitha Saldanha , Anand Abhishek , Patidar Rajesh , Premalata C. S. 
Published: January 2019

Abstract
Background: Gastrointestinal tract (GIT) is the most common extranodal site for non-Hodgkin's lymphoma (NHL) and constitutes about 10%-15% of all NHL. This was a prospective study to evaluate the epidemiological, clinicopathological characteristics, and treatment outcome of primary GIT diffuse large B-cell lymphoma (PGIL). Materials and Methods: Newly diagnosed patients of PGIL with DLBCL histology were eligible. Lugano staging system was used. All patients were treated with prephase treatment (1 mg vincristine and 100 mg prednisolone) followed by CHOP-based chemotherapy (with or without rituximab) as definitive treatment. Results: A total of 21 patients of PGIL were diagnosed. The median age was 46 years (range: 27–69 years) with male:female ratio of 2:1. Dull aching abdominal pain was the most common presenting complaint. Stomach was the most common site involved (52.4%, n = 11) followed by the colon (23.8%, n = 5). The estimated median survival in patients with Stage IV disease was significantly lower as compared to patients with localized disease (Stage I and II) (6.23 months vs. 23.4 months; P = 0.04). Patients, who did not achieve complete response (CR), had 15.5 times higher risk of death, as compared to those who achieved CR (P = 0.01). Conclusions: Stomach was the most common site for PGIL. Localized disease and CR after first-line chemotherapy were associated with better survival. A higher cost of rituximab was the prohibitive factor for cure in these patients.
Pressurized intraperitoneal aerosol chemotherapy procedure for nonresectable peritoneal carcinomatosis: First Indian study
Authors: Somashekhar S. P. , Ashwin K. R. , Kumar C. Rohit , Rauthan Amit , Rakshit Sushmita H. 
Published: January 2019

Abstract
Background: Peritoneal carcinomatosis (PC) is a common evolution of abdominal cancers and is associated with poor prognosis. A few selected patients have option of cytoreductive surgery and hyperthermic intraperitoneal chemotherapy, but majority who are not eligible for curative approach can undergo pressurized intraperitoneal aerosol chemotherapy (PIPAC). It is an emerging field of research with major therapeutic potential. It is a safe and innovative approach, which enhances the effect of chemotherapy without major toxicity. Methods: Between June 2017 and December 2017, 21 PIPAC applications in seven patients with standard chemotherapy regimen every 6 weeks at 37°C and 12 mmHg for 30 min was performed. The patients' demographics, perioperative findings, adverse events, and outcomes were prospectively recorded. Results: Twenty-one PIPAC administrations were performed in 7 patients with PC from various pathologies. The median hospital stay was 1 day. All the patients had symptomatic relief with complete resolution of ascites. There was no major perioperative complications. CTCAE Grades 1 and 2 were observed in three patients, for abdominal pain and nausea. Renal and hepatic functions were not impaired. Of the seven patients, one patient had complete histological remission; three patients had partial response, one had stable disease and one patient had no response with clinical progression. Conclusion: Our results show the feasibility and safety of PIPAC in Indian patients. The procedure has low morbidity with no mortality with the short learning curve. It can be easily adapted for Indian patients with diffuse PC as a palliative option apart from systemic chemotherapy.