bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dual‐Functional Small Molecules for Generating an Efficient Cytochrome P450BM3 Peroxygenase
Authors: Ma Nana , Chen Zhifeng , Chen Jie , Chen Jingfei , Wang Cong , Zhou Haifeng , Yao Lishan , Shoji Osami , Watanabe Yoshihito , Cong Zhiqi 
Published: February 2018

AbstractWe report a unique strategy for the development of a H2O2‐dependent cytochrome P450BM3 system, which catalyzes the monooxygenation of non‐native substrates with the assistance of dual‐functional small molecules (DFSMs), such as N‐(ω‐imidazolyl fatty acyl)‐l‐amino acids. The acyl amino acid group of DFSM is responsible for bounding to enzyme as an anchoring group, while the imidazolyl group plays the role of general acid–base catalyst in the activation of H2O2. This system affords the best peroxygenase activity for the epoxidation of styrene, sulfoxidation of thioanisole, and hydroxylation of ethylbenzene among those P450–H2O2 system previously reported. This work provides the first example of the activation of the normally H2O2‐inert P450s through the introduction of an exogenous small molecule. This approach improves the potential use of P450s in organic synthesis as it avoids the expensive consumption of the reduced nicotinamide cofactor NAD(P)H and its dependent electron transport system. This introduces a promising approach for exploiting enzyme activity and function based on direct chemical intervention in the catalytic process.
The Large Second‐Harmonic Generation of LiCs2PO4 is caused by the Metal‐Cation‐Centered Groups
Authors: Cheng Xiyue , Whangbo Myung‐Hwan , Guo Guo‐Cong , Hong Maochun , Deng Shuiquan 
Published: February 2018

AbstractWe evaluated the individual atom contributions to the second harmonic generation (SHG) coefficients of LiCs2PO4 (LCPO) by introducing the partial response functionals on the basis of first principles calculations. The SHG response of LCPO is dominated by the metal‐cation‐centered groups CsO6 and LiO4, not by the nonmetal‐cation‐centered groups PO4 expected from the existing models and theories. The SHG coefficients of LCPO are determined mainly by the occupied orbitals O 2p and Cs 5p as well as by the unoccupied orbitals Cs 5d and Li 2p. For the SHG response of a material, the polarizable atomic orbitals of the occupied and the unoccupied states are both important.
Perfluoroaryl Bicyclic Cell‐Penetrating Peptides for Delivery of Antisense Oligonucleotides
Authors: Wolfe Justin M. , Fadzen Colin M. , Holden Rebecca L. , Yao Monica , Hanson Gunnar J. , Pentelute Bradley L. 
Published: February 2018

AbstractExon‐skipping antisense oligonucleotides are effective treatments for genetic diseases, yet exon‐skipping activity requires that these macromolecules reach the nucleus. While cell‐penetrating peptides can improve delivery, proteolytic instability often limits efficacy. It is hypothesized that the bicyclization of arginine‐rich peptides would improve their stability and their ability to deliver oligonucleotides into the nucleus. Two methods were introduced for the synthesis of arginine‐rich bicyclic peptides using cysteine perfluoroarylation chemistry. Then, the bicyclic peptides were covalently linked to a phosphorodiamidate morpholino oligonucleotide (PMO) and assayed for exon skipping activity. The perfluoroaryl cyclic and bicyclic peptides improved PMO activity roughly 14‐fold over the unconjugated PMO. The bicyclic peptides exhibited increased proteolytic stability relative to the monocycle, demonstrating that perfluoroaryl bicyclic peptides are potent and stable delivery agents.
Halogen‐free intumescent flame‐retardant ethylene‐vinyl acetate copolymer system based on organic montmorillonite and graphene nanosheets
Authors: Wang Xuebao , Bi Bo , Liu Jiangwei , Yang Shousheng , Zhou Liang , Lu Lingang , Wang Yong , Xu Fan , Huang Run 
Published: February 2018

ABSTRACTHalogen‐containing flame retardants are not preferred for environmental reasons. Herein, a halogen‐free intumescent flame‐retardant ethylene‐vinyl acetate copolymer (EVA/IFR) system containing organic montmorillonite (OMMT) and graphene nanosheets (GNSs) is fabricated with well dispersion structure, enhanced thermal‐oxidative resistance at high temperature. Interestingly, the amount of residual chars from thermogravimetric analysis is increased to 12.7 wt % at 700 °C, the EVA/IFR composite containing both OMMT and GNSs exhibits the best flame retardancy with the lowest peak heat release rate value of 529.58 kW m−2, and the highest limited oxygen index value of 24.8%. The excellent flame retardancy is attributed to the formation of complete and compact protective char layer. Furthermore, the decreases of the mechanical properties caused by the addition of IFR are relieved and a high volume resistivity is maintained when combining OMMT and GNSs in the EVA/IFR system together. © 2018 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2018, 135, 46361.
Facile Synthesis of A 3D Flower‐Like Mesoporous Ni@C Composite Material for High‐Energy Aqueous Asymmetric Supercapacitors
Authors: Liu Song , An Cuihua , Zang Lei , Chang Xiaoya , Guo Huinan , Jiao Lifang , Wang Yijing 
Published: February 2018

AbstractA 3D flower‐like mesoporous Ni@C composite material has been synthesized by using a facile and economical one‐pot hydrothermal method. This unique 3D flower‐like Ni@C composite, which exhibited a high surface area (522.4 m2 g−1), consisted of highly dispersed Ni nanoparticles on mesoporous carbon flakes. The effect of calcination temperature on the electrochemical performance of the Ni@C composite was systematically investigated. The optimized material (Ni@C 700) displayed high specific capacity (1306 F g−1 at 2 A g−1) and excellent cycling performance (96.7 % retention after 5000 cycles). Furthermore, an asymmetric supercapacitor (ASC) that contained Ni@C 700 as cathode and mesoporous carbon (MC) as anode demonstrated high energy density (60.4 W h kg−1 at a power density of 750 W kg−1).
Current and potential ecodesign integration in small and medium enterprises: Construction and related industries
Authors: Denac Matjaž , Obrecht Matevž , Radonjič Gregor 
Published: February 2018

AbstractThe ecodesign of products is becoming an important part of environmental and innovation policies in many sectors. The aim of this study was to understand how product ecodesign activities can be effectively introduced to stimulate step changes in small and medium enterprises (SMEs) in the construction and building sector, together with SMEs from related industrial sectors. Based on an interview study among Slovenian SMEs, the general level of managers’ awareness of how their products impact the environment and how they understand the concept of product ecodesign to provide potential measures for ecodesign implementation was investigated. The results showed the quantified aggregate of degrees of implementation related to individual ecodesign strategies based on life cycle phases and individual environmental aspects. The study revealed that the most frequently implemented criteria were maximizing product lifetime and ease of reuse, disassembly and recycling. The highest ecodesign implementation level was observed in the “design for use” phase.
Establishment and validation of a two‐step screening scheme for improved performance of serological screening of nasopharyngeal carcinoma
Authors: Li Tingdong , Guo Xiaoyi , Ji Mingfang , Li Fugui , Wang Han , Cheng Weimin , Chen Honglin , Ng Munhon , Ge Shengxiang , Yuan Yong , Xia Ningshao 
Published: February 2018

AbstractNasopharyngeal carcinoma (NPC), which is closely associated with Epstein–Barr virus (EBV), is one of the most prevalent cancers in southeast China. Most NPC patients are diagnosed at late stage due to inconspicuous symptoms at the early stage, and the prognosis of these patients is poor. The early diagnosis rate of NPC could be significantly increased by serological screening, but the positive predictive value (PPV) is relatively low. A simple two‐step serological screening scheme was established to improve the PPV of the screening strategy and was validated by a prospective cohort. Serum antibodies specific for EBNA1, Zta, Thymidine Kinase (TK), EAD, EAR, and VCA were detected by enzyme‐linked immunosorbent assay. The combination of EBNA1/IgA and VCA/IgA was used in the first step of screening, and anti‐early antigens (EAs) were used in the second step of screening. EAD/IgA was the most prominent marker in the second step of screening, and other anti‐EAs were complementary to EAD/IgA. As validated by a prospective cohort including 4200 participants, using the combination of EAD/IgA and TK/IgA in the second step decreased the number of high‐risk participants from 128 to 27, and increased the PPV from 4.69% to 18.52%, with only one very early‐stage case missed. The two‐step screening scheme provides a standardized approach for NPC screening with an improved PPV and may be used in future field studies. With this two‐step serological screening method, more people benefit from the screening program without increasing the need for fiberoptic endoscopy.
The poor outcome of second primary oral squamous cell carcinoma is attributed to Bmi1 upregulation
Authors: Hu Qinchao , Wu Tong , Chen Xiaobing , Li Huan , Du Zhicheng , Hao Yuantao , Peng Jianmin , Tai Shanshan , Song Ming , Cheng Bin 
Published: February 2018

AbstractRadiotherapy for nasopharyngeal carcinoma has been reported to cause second primary oral squamous cell carcinoma (s‐OSCC). The prognosis and pathologic characteristic of s‐OSCC are largely unknown. Bmi1 was associated with the repair of radiation‐induced DNA damage, suggesting its possible involvement in the pathologic process of s‐OSCC. Herein, we compared the prognosis between s‐OSCC and primary OSCC (p‐OSCC) and explored the involvement of Bmi1 in s‐OSCC development. In this retrospective study, s‐OSCC and p‐OSCC patients were matched by propensity scores. Their outcomes were compared by univariate and multivariate analyses. The expression of Bmi1 in s‐OSCC and p‐OSCC was detected by immunohistochemistry (IHC). Radiation‐induced Bmi1 alteration in early‐stage was explored in a rat model and HaCaT cells. After matching, 116 pairs of patients with highly balanced characteristics were included. In univariate analysis, the overall survival (OS), disease‐specific survival (DSS), and local recurrence‐free survival (LRFS) were poorer in s‐OSCC than in p‐OSCC (P < 0.05), while their regional metastasis‐free survival (RMFS) was parallel (P = 0.112). Multivariate analysis further revealed that radiotherapy history was an independent risk factor for OS, DSS, and LRFS (P < 0.05). IHC results showed that the positive rate of Bmi1 was higher in s‐OSCC (P = 0.0027). In a rat model of radiotherapy‐induced mucositis, Bmi1 upregulation was observed 8 days after irradiation. Consistently, Bmi1 was upregulated in HaCaT cells 1 h after irradiation, and its upregulation was in accord with X‐ray exposure duration. In conclusion, the prognosis of s‐OSCC is poorer as compared to p‐OSCC, which may be attributed to Bmi1 upregulation.
Clinical outcomes of radio‐hyperthermo‐chemotherapy for soft tissue sarcoma compared to a soft tissue sarcoma registry in Japan: a retrospective matched‐pair cohort study
Authors: Aiba Hisaki , Yamada Satoshi , Mizutani Jun , Yamamoto Norio , Okamoto Hideki , Hayashi Katsuhiro , Kimura Hiroaki , Takeuchi Akihiko , Miwa Shinji , Kawai Akira , Yoshimura Kenichi , Tsuchiya Hiroyuki , Otsuka Takanobu 
Published: February 2018

AbstractRegional hyperthermia is considered to enhance the antitumor effects of chemotherapy and radiotherapy. In this study, we confirmed the efficacy of concomitant radiotherapy, hyperthermia, and chemotherapy (RHC) for neoadjuvant treatment of malignant soft tissue sarcoma (STS). From 1994 to 2013, we performed RHC in 150 patients. This study was limited to 60 patients using the following exclusion criteria: salvage for recurrence or unplanned excision, trunk location, metastasis at initiation, non‐STS, and no definitive surgery. As a control group, we collected data from 11,031 patients in the Bone and Soft Tissue Tumor Registry in Japan (BSTT). We performed multivariate logistic regression analysis, and propensity scores were created for comparisons between groups. The primary outcome of this study was to compare oncologic outcomes (5‐year local control rate [LC] and overall survival rate [OS]). In the RHC group, two local recurrences (3.3%) occurred, and no patients underwent amputation. Margins of definitive surgery were not identical between groups [wide margins (60.0% vs. 85.3%), marginal margins (28.3% vs. 10.5%), and intralesional margins (7.4% vs. 4.2%), RHC and BSTT groups, respectively, P < 0.001]. After adjustment, the difference in OS was not significant between groups (HR = 1.26, P = 0.532); however, a statistically significant difference in LC was observed (HR = 4.82, P = 0.037). RHC resulted in a high LC at 5 years compared to the BSTT group, and amputation was averted in the RHC group, despite the wider margins in the BSTT group. This indicates that less invasive surgery might be achieved with effective neoadjuvant therapy.
Three New Indole Diketopiperazine Alkaloids from Aspergillus ochraceus
Authors: Wen Huiling , Liu Xiaorui , Zhang Qing , Deng Yanfang , Zang Yi , Wang Jianping , Liu Junjun , Zhou Qun , Hu Linzhen , Zhu Hucheng , Chen Chunmei , Zhang Yonghui 
Published: February 2018

Asperochramides A – D (1 – 4), a new natural product and three new indole diketopiperazine alkaloids, along with seven known analogs (5 – 11), were isolated from the ethyl acetate extract of Aspergillus ochraceus. Their structures were elucidated by extensive spectroscopic analyses, ECD calculation, and single‐crystal X‐ray diffraction analysis. Compounds 3 and 4 represent a rare group of indole diketopiperazine alkaloid with a 3‐hydroxyl‐2‐indolone moiety. The in vitro anti‐inflammatory effects of compounds 1 and 3 – 11 were investigated by using LPS‐stimulated murine macrophage RAW 264.7 cells. Compounds 1, 8, 10, and 11 showed potential anti‐inflammatory activities.
Transcatheter aortic valve implantation via the superficial femoral artery: An underused access route?
Authors: Saraf Smriti , Cockburn James , Alsanjari Osama , Hildick‐Smith David 
Published: February 2018

AbstractCommon femoral arterial (CFA) access is the most commonly used access route for transcatheter aortic valve implantation (TAVI). In majority of cases, it is easily accessible percutaneously without requiring surgical cut down. However, in patients with high body mass index (BMI) or central obesity, it can be more than 8–10 cm below the skin making the procedure more technically demanding and satisfactory hemostasis more difficult to achieve. The superficial femoral artery (SFA) lies only a few centimeters distal to the CFA with little compromise on vessel caliber, yet can allow more suitable access in certain patients with a high BMI. We describe three cases in which SFA access was successfully used as the primary delivery route for TAVI.
Incidence, predictors and longer‐term impact of troponin elevation following hybrid chronic total occlusion percutaneous coronary intervention
Authors: Dautov Rustem , Ybarra Luiz Fernando , Nguyen Can Manh , Gibrat Claire , Joyal Dominique , Rinfret Stéphane 
Published: February 2018

AbstractObjectivesWe examined the incidence of periprocedural cardiac enzyme rise (PCER) [troponin T (TnT) or high‐sensivity (hs)TnT >5× the upper limit of normal (ULN)] and periprocedural myocardial infarction (PMI), predictors of PCER and impact of PCER on the longer‐term major adverse cardiac events (MACE) following hybrid chronic total occlusion (CTO) percutaneous coronary intervention (PCI).BackgroundPCER and PMI after CTO PCI, risk factors for PCER and its impact on longer‐term MACE are not fully understood.MethodsAmong 469 CTO PCI cases performed between 01/2010 and 12/2015, next‐day TnT or hsTnT was measured in 455 (97%). We examined the incidence of PCER and PMI (with clinical context or TnT ≥70× ULN). In 269 successful cases who had TnT measured, longer‐term MACE (death, MI or target‐vessel revascularisation/re‐occlusion) were assessed.ResultsOverall, 420 CTOs (92.3%) were treated successfully. PCER was documented in 34%, while PMI in 2.9%. By multivariable analyses, higher J‐CTO score (OR = 1.3 per point; P = 0.002), lower creatinine clearance (OR = 1.01 per each cc/min decrease; P < 0.0001) and recent MI (OR = 2.4; P = 0.007) were independent pre‐PCI risk factors for PCER. Among procedural variables, retrograde approach (OR = 1.9; P = 0.014) and procedure duration (OR = 1.2 per 30 min; P = 0.007) were associated with PCER. At a median follow‐up of 396 days following successful CTO PCI, PCER was not associated with higher MACE (9.3% vs. 8.1%; P = 0.60), and was not a predictor of MACE in multivariable analysis.ConclusionsPCER following hybrid CTO PCI is detected in 1/3 of patients. However, true PMI occurs in 2.9%. PCER does not predict adverse long‐term outcomes.
Coronary sinus perforation during reducer implantation
Authors: Cortese Bernardo , di Palma Gaetano , Latini Roberto 
Published: February 2018

AbstractCoronary Sinus Reducer (Neovasc, Inc., Richmond B.C., Canada) has shown to be an effective and safe treatment option for the treatment of refractory angina. Until now, a few number of complications related to its implantation have been reported. Coronary sinus perforation is a rare complication, more often related to cardiac surgery procedures. We report the first case of coronary sinus perforation after a sinus Reducer implantation.
Ionic Liquids in Asymmetric Synthesis: An Overall View from Reaction Media to Supported Ionic Liquid Catalysis
Authors: Karimi Babak , Tavakolian Mina , Akbari Maryam , Mansouri Fariborz 
Published: February 2018

AbstractIonic liquids, as a special class of organic compounds, have attracted ever‐growing interest in recent years. They have been employed in many organic transformations as a green alternative to volatile organic solvents and as a catalyst to modify catalytic activity and recyclability. Recent developments have demonstrated that ionic liquids might also have many benefits in asymmetric reactions. In this review, we survey the use of ionic liquids in asymmetric transformations, including the use of ionic liquids as reaction media in asymmetric reactions, ionic‐liquid‐tagged chiral catalysts for use in asymmetric synthesis, and supported ionic liquid catalysts in asymmetric transformations.
Expanding the Scope of Photocatalysis: Atom Transfer Radical Addition of Bromoacetonitrile to Aliphatic Olefins
Authors: Voutyritsa Errika , Triandafillidi Ierasia , Kokotos Christoforos G. 
Published: February 2018

AbstractAn efficient photocatalyzed bromocyanomethylation of alkenes is reported. Among a range of organocatalysts and metal complexes, Ir(ppy)3 proved to be the best photocatalyst in promoting the addition of BrCH2CN to olefins. This photocatalytic atom transfer protocol can be expanded into a wide substrate scope of aliphatic olefins bearing various functional groups, leading to the corresponding products in good to excellent yields. In addition, linchpin catalysis was developed, since the bromo group can undergo further transformation into useful functional groups, such as the synthesis of amino acids.
Microwave Reaction: A Facile Economic and Green Method to Synthesize Oxygen‐Decorated Graphene from Carbon Cloth for Oxygen Electrocatalysis
Authors: Zhang Weifeng , Li Yaguang , Xu Yingqi , Zhang Zisheng , Wang Shufang , Fu Guangsheng 
Published: February 2018

AbstractOxygen‐functionalized graphene is active for oxygen evolution reaction (OER). However, the high costs, complex instruments and pollution risks in the synthesis process make oxygen‐functionalized graphene difficult to be industrialized. The microwave reaction has originally been used to remove the oxygen groups on graphene structures. In this work, the microwave reaction is reversed to decorate oxygen groups on graphene from carbon cloth, by solely using a household microwave oven. After microwave treatment, the carbon cloth shows greatly improved OER performance with a much lower overpotential of 417 mV, in comparison with the pristine carbon cloth (627 mV), due to the decoration of oxygen groups on graphene, a higher electron conductivity and a higher specific surface area. Meanwhile, an overpotential of 542 mV at 10 mA cm−2 is obtained in an acidic electrolyte, which is one of the best values for non‐precious OER catalysts in acidic media. This work provides a facile, green and economic method for producing functionalized carbon catalysts for OER.
Iron and Nitrogen Co‐doped Carbide‐Derived Carbon and Carbon Nanotube Composite Catalysts for Oxygen Reduction Reaction
Authors: Ratso Sander , Käärik Maike , Kook Mati , Paiste Päärn , Kisand Vambola , Vlassov Sergei , Leis Jaan , Tammeveski Kaido 
Published: February 2018

AbstractReplacing Pt‐based catalysts with noble‐metal free catalysts for the oxygen reduction reaction (ORR) is one of the most important topics currently in electrocatalysis. Iron‐ and nitrogen‐doped carbon materials have shown great promise in this area. In this work, we demonstrate the remarkable electrocatalytic activity towards the ORR of carbide‐derived carbon (CDC) and multi‐walled carbon nanotube (MWCNT) composite catalysts. The CDC material is synthesized from titanium carbide and doped using 1,10‐phenanthroline and iron (II) acetate. The material is then mixed with MWCNTs and further modified with dicyandiamide (DCDA) and additional iron by using a multi‐step pyrolysis procedure. The morphology, structure, porosity, and elemental composition are then comprehensively studied with scanning electron microscopy, X‐ray photoelectron spectroscopy, N2 physisorption, and inductively coupled plasma mass spectroscopy. The electrocatalytic activity of the catalysts for the ORR is studied using the rotating disk electrode method and in a single‐cell anion exchange membrane fuel cell using the Tokuyama A201 membrane.
Predictive risk factors for recurrent atrial fibrillation after modified endoscopic ablation: A 2‐year follow‐up
Authors: An Kang , Zhu Jiaquan , Ma Nan , Tang Min , Mei Ju 
Published: February 2018

BackgroundOur previous study reported a modified endoscopic procedure for nonvalvular atrial fibrillation (AF) that requires only 3 ports in the left chest wall.HypothesisCertain preoperative variables might be predictive risk factors for AF recurrence among patients who underwent this procedure.MethodsFrom October 2010 to April 2014, 114 patients with either paroxysmal AF (PAF) or nonparoxysmal AF (non‐PAF) underwent the procedure and completed postoperative cardiac‐rhythm measurement via electrocardiography and Holter monitoring. Univariate and multivariate analyses of the possible AF‐related risk factors were conducted.ResultsDuring 2‐year follow‐up, 99 of 114 patients (86.8%) were free from atrial tachyarrhythmia. Results from univariate analyses showed that AF duration, left atrial diameter (LAD), left atrial minimum volume, left atrial empty fraction, left atrial expansion index, and left atrial active empty fraction (LAAEF) were significantly associated with postoperative AF recurrence. Results from multivariate analyses showed that AF duration (odds ratio [OR]: 1.194, 95% CI: 1.063‐1.340, P = 0.003), LAD (OR: 1.101, 95% CI: 1.005‐1.205, P = 0.039), and LAAEF (OR: 0.490, 95% CI: 0.277‐0.865, P = 0.014) were independent risk factors. There was no difference in AF recurrence between patients with PAF and non‐PAF (P = 0.250).ConclusionsOur 2‐year follow‐up study suggested that low LAAEF, long AF duration, and large LAD might be potential predictive risk factors for AF recurrence. Patients with PAF and non‐PAF had a similar AF recurrence rate after modified endoscopic ablation.