bluuebunny/crossref_metadata_2025_split huggingface dataset:
Racemose neurocysticercosis of the basal arachnoid cisterns: illustrative case
Authors: Thibault Drew , Ravina Kristine , Cuoco Joshua A , Adhikari Srijan , Stump Michael S , Rogers Cara M 
Published: October 2024

BACKGROUND
Neurocysticercosis is a parasitic infection of the central nervous system caused by the helminth Taenia solium. Racemose neurocysticercosis is a rare form of the disease that specifically involves cerebrospinal fluid–filled spaces in the brain and carries a high rate of complications and mortality.

OBSERVATIONS
This report describes the case of a 37-year-old man who developed headaches and nausea, which were found to be secondary to racemose neurocysticercosis. He ultimately required an endoscopic third ventriculostomy, which provided transient symptom relief. In the weeks following the procedure, his symptoms returned, at which point a recommendation to proceed with a ventriculoperitoneal shunt was made.

LESSONS
The presentation of racemose neurocysticercosis is wide-ranging and often nonspecific. Patients who respond well to initial surgical management with endoscopic third ventriculostomy can still require more durable measures, such as a ventriculoperitoneal shunt, in the following months.
https://thejns.org/doi/10.3171/CASE24489
Lesion-like effect of gliosis secondary to deep brain stimulation electrode infection: illustrative case
Authors: Vilela-Filho Osvaldo , Oliveira-Alves Déborah , Alvim-Alves Déborah , Silva Délson J 
Published: October 2024

BACKGROUND
Deep brain stimulation (DBS) is commonly used to treat Parkinson's disease (PD) and other movement disorders when other treatments fail. Although DBS can significantly improve motor symptoms, it carries risks such as infections, which can require multiple surgeries and prolonged antibiotic therapy. Research on the long-term neurological effects of DBS-related infections is limited.

OBSERVATIONS
A 58-year-old man with a 13-year history of PD, refractory to optimized clinical management, underwent subthalamic nucleus (STN) DBS after previous contralateral lesioning of the posterior subthalamic area. Postoperatively, the DBS lead migrated upward and was repositioned, but he developed perielectrode cerebritis 5 days later. The DBS system was completely removed, and he underwent a 28-day course of intravenous antibiotics. Initially, his motor symptoms remained unchanged, but 4 months later, he experienced a significant and sustained motor symptom improvement that continued until the last follow-up assessment (40 months). Magnetic resonance imaging performed 2 years after the explantation showed gliosis and hemosiderin deposition in the STN, suggesting that the infection-induced gliosis had a lesion-like effect, leading to the observed clinical improvement.

LESSONS
This case suggests that infection-induced gliosis from DBS complications can unexpectedly result in long-term motor symptom improvements, potentially influencing future management strategies for similar cases.
https://thejns.org/doi/10.3171/CASE24502
Solving the problem of automating the learning process through experimental search for an individual educational trajectory
Authors: Diachenko M. S. , Leonov A. G. 
Published: October 2024

The automation of the educational process and the introduction of adaptive learning are becoming the most effective ways to solve the problem of the shortage of highly qualified personnel under digitalization of education.The article proposes an approach to the formation of individual educational trajectories as a composition of pedagogical experiments, which is characterized by good interpretability in comparison with methods based on machine learning. This approach, unlike most modern parametric solutions, involves an experimental search for an individual educational trajectory for each student of the group, and not just a part of the students of the group in which the application of a specific parametric solution is effective. It is proposed that the procedure of selecting educational technologies be automated similarly to how it is done by teachers in small groups, for example, by applying the automated trial and error method and its optimized versions. The possibility of transferring educational technologies to other courses is considered, without which technology reuse and scaling are impossible. A new function of the learning system is described, i. e. the formation of an individual educational trajectory, which is used throughout the study in higher education.The obtained results can be used in the construction of modern systems of individualization of learning and conducting distributed pedagogical experiments, which, in turn, reduces the threshold of teachers’ entry into the study of new learning technologies and accelerates the widespread dissemination of promising educational technologies.
Educational and professional task as a means of assessing the professional competencies of IT students based on the requirements of employers
Authors: Karakozov S. D. , Petrov D. A. , Khudzhina M. V. 
Published: October 2024

One of the most important tasks of higher education under digitalization of all spheres of economy and society is training specialists in IT (including specialists in web development) who are in demand in the labor market. To address this task successfully, it is necessary to have close interaction between universities and employers at all stages of the implementation of basic professional educational programs from their creation to the assessment of the formation of professional competencies.The article is focused on the current problem of choosing and designing effective tools for assessing professional competencies of IT students within the framework of advanced training in web development. The article carries out an analysis of psychological and pedagogical literature in order to determine the optimal means of assessing professional competencies of students. The use of educational professional tasks as a means of modeling the professional activity of a graduate and evaluating the educational results of the university study process is substantiated. It is substantiated that employers gain a special role in the design and implementation of educational programs, including the formation of the repertory and content of educational professional tasks and so the necessity of employers’ representatives’ participation in the process of assessing the development level of professional competencies is explained.
Technology of creating an innovative textbook for teacher education system
Authors: Barkhatova D. A. , Maryasova A. N. , Pak N. I. , Faut Yu. V. 
Published: October 2024

The transformation of education, caused by the constantly changing demands of society and the avalanche growth of information, necessitates the search for new means of training future teachers, focused on the formation of universal qualities of a specialist. The creation of psycho-pedagogical classes requires expanded research into ways to improve pedagogical training with continuity at all levels, starting from school. Considering the focus on professional training, it is important to model the structure and content of educational tools that allow forming not only subject knowledge but also the readiness of future teachers to “learn to teach” adequately to the cognitive characteristics of modern students and the trends in the formation of digital content.The aim of the article is to substantiate the method of creating end-to-end inversion textbooks that allow forming and developing the readiness to learn to teach in students planning their future professional activities in the educational field (by the example of studying the topic of the informatics course “Information and information processes”).The literature analysis allowed us to identify three tools for modeling the format of presentation and structuring of the textbook content: the “inverted” or inversion (question-task) format of the structural composition of educational content; the end-to-end or vertical selection of educational content according to the principle of “vertical lever”, the principle of “transparent” box” based on structural mental diagrams for visualizing all components of educational material (theory, tasks, control methods). Using the example of the topic “Information and information processes”, the article shows the technology of applying these tools in compiling of innovative teaching resources is shown.An expert assessment of the created textbook confirmed the possibility and feasibility of its use in psycho-pedagogical classes and pedagogical universities for training, self-study, and self-control of students.
Development of a digital profile of a university teacher
Authors: Knyazeva N. V. , Mikhailova I. P. , Usmanova N. V. , Shindina T. A. 
Published: October 2024

Currently, digitalization is a cross-cutting business process in the higher education system. Digital transformation has affected both the functioning of the higher education system in general and the activities of each university and participants in the educational process in particular.An important problem is the adaptation of teachers to a dynamically changing digital environment, taking into account the requirements for the level of digital competencies resulting from the specifics of the digital environment, and the already existing level of digital literacy of the teacher. In a modern university, a teacher is a multifunctional subject who performs educational, methodological, research, and administrative tasks, the solution of which is often associated with working in the digital environment of an educational organization.The article presents a model of the digital environment of a university with an emphasis on human resources and digital services is presented, which allows the development of a policy for managing changes and transformation processes in universities. The thesis that the digital environment determines the level of requirements for the digital competencies of teachers is substantiated.The authors propose an evaluation method for the teacher’s digital literacy, which makes it possible to develop the teacher’s digital profile considering the educational, methodological, administrative, and research activities.
Improving the efficiency of resource allocation in educational content delivery networks using the 1C:ESB integration bus
Authors: Prokurovskiy A. A. , Andreev I. A. , Tutova N. V. 
Published: October 2024

Learning Management Systems (LMS) play a key role in the educational process by providing students with various educational content and instructors with tools to monitor student knowledge and assess progress. However, as the number of students increases, the load on data transmission channels increases, which can lead to a decrease in the quality of learning. To solve this problem, Content Delivery Networks (CDN) are used to speed up the loading of websites and reduce the load on servers. CDN ensure the availability and security of websites and improve their scalability (resistance to smooth load growth) by distributing content across a network of servers around the world, allowing users to access content faster and more efficiently.Integration data exchange bus (Enterprise Service Bus, ESB) can be an effective tool for optimizing CDN content distribution algorithm. It allows integration of different systems and applications, enabling data exchange between them. This is particularly useful in the context of distance learning, which requires fast and reliable delivery of educational content, feedback, learning analytics, etc. Implementing an integration bus of data exchange with LMS-based distance learning system can be a key factor in ensuring an efficient and quality educational process. The article considers the properties and characteristics of the integration bus and justifies the use of the integration bus to optimize the algorithm of CDN content distribution, in particular in LMS.
Polymersomes as Novel Drug Delivery Alternative to Conventional Liposomes
Authors: Marwa malik Kamil  , Mohammed J. Neamah  , Yasir Qasim almajidi  
Published: October 2024

الهدف من البحث الطبي في جميع أنحاء العالم هو تحسين صحة ورفاهية المرضى. تعد تقنية النانو مجالًا ناشئاً يركز الآن بشكل كبير على مجال الطب أدى البحث المستمر ف ي هذا القطاع إلى ظهور نظام جديد يعُرف باسم
"طب النانو"، والذي يحاول توفير خيارات علاج جديدة مع تحسين الفعالية العلاجية الحالية الأدوية. استخدمناGoogle وPubMed لإجراء مراجعة الأدبيات حول الموضوعات التالي ة من أجل الحصول على أحد ثالمعلومات حول الاختراقات الحديثة في مجال البوليمرات في الطب النانوي. لقد حظي الطب النانوي باهتمام كبير في الأبحاث الحديثة في جميع أنحاء العالم، وأدى إلى ابتكار علاجات طبية جديدة. تتضمن بعض هذه الطرق الإذابة
أو استهداف علاج السرطان أو استخدامها كأداة تشخيصية. تدُرس الآن البوليمرات ، وهي حويصلات برمائية صناعية مكونة من بوليمرات كيميائية مختلفة، لتقديم تحقيقات مختلفة لتصوير الأنسجة / الأعضاء المستهدفة،بالإضافة إلى الأدوية السامة للخلايا للخلايا السرطانية من أجل العلاج الجيني. نستكشف الأفكار الحالية حو لالبوليمرات واستخداماتها الطبية في هذه المراجعة، وهي قضي ة رئيسية متنامية في مجال المحاكاة النانوية. تم تطوير البوليمرات النانوية الحجم كحاملات للعديد من التطبيقات الطبية نتيجة للتقدم في الطب النانوي.
Bibliometric analysis of the flow of publications of Russian journals of the Higher Attestation Commission under the code 5.10.4 Library Science, Bibliography and Book Studies
Authors: Maslova Yu. V. , Borodina S. D. , Mansurova A. R. 
Published: October 2024

The authors discuss the results of the bibliometric analysis of Russian journals in the field of library science, bibliography and book studies. The purpose of the study is to build the rating of scientific journals on the List of the Higher Attestation Commission in the code 5.10.4 Library Science, Bibliography and Book Studies, which will allow potential authors to navigate publications: in their citation, the average Hirsch index of regular authors, the number of views and downloads of articles, the quartile of the journal that determines the journal relevance and authority with the scientific community. These indicators, especially the quartile, are crucial for the authors who seek publishing their papers to prepare for their dissertation defense, so that they avoid mistakes when choosing a journal.The bibliometric approach to professional periodicals, its analysis based on the ratings of the RSCI and the Higher Attestation Commission, is embraced by the leading library scientists which is evidenced by publications of the Russian State Library, Russian Library Association, State Public Scientific Technological Library of the Russian Academy of Sciences Siberian Branch, etc.The significance of this study lies in studying the periodicals included in the List of the Higher Attestation Commission, and providing the comparative analysis of indicators affecting the journals ratings. According to the authors, the systematic bibliometric analysis based on RSCI indicators reveals the potential of individual journals, directions for their improvement and enables to determine the core serials of the industry documentary stream.The findings of the study are seen as significant in the light of the changing specialty itself, the growing interest to domestic periodicals against the background of sanctions in the field of scientific information. The authors have developed their recommendations for journals’ editorial boards.
The review of advanced methods and techniques for estimating research output in bibliometrics (Part 1)
Authors: Zemskov A. I. , Telitsyna A. Y. 
Published: October 2024

The authors explore the significant changes in traditional bibliometrics, including distinctive innovations in this area. Within the five-year period (2019– 2024), two processes have had a significant impact on the methods and technologies: these are the COVID-19 pandemic period (recognition of the importance of open research outcomes) and the period of sanctions (an attempt to exclude Russia from the global scientific process).The authors review in brief the improvements of existing methods, e. g. the introduction of the system of beamplot diagrams and research-based citation analysis. The role of scientometrics in global rankings is evaluated. The focus is also made on new vectors of analysis development, such as altmetrics and artificial intelligence. The application of artificial intelligence tools not only ensures high speed but also lays the basis for the entirely new system for comparing scientific publications with the existing array of accumulated knowledge.
Why students feel anxious in group work: an investigation into students’ perspectives on the sources of their anxious experiences in group work
Authors: Xethakis Larry J. , Rupp Michael , Plummer Brendan R. B. 
Published: October 2024

IntroductionThis large-scale, mixed-methods study aimed to uncover sources of learner anxiety when interacting in small groups in the language classroom. A secondary aim of the study was to examine relationships between these sources and learners’ levels of small-group anxiety.MethodsData was gathered from 1,344 learners enrolled in English classes at four universities in western Japan. Qualitative content analysis was employed to identify anxiety-inducing situations described in learner’ responses, and categorize these situations based on the underlying source of anxiety.ResultsThe analysis revealed two primary sources of small-group anxiety: interacting with other learners and L2 communication. The most prominent interaction-related situations were interacting with new people, expressing opinions, and uncomfortable silence, while those related to L2 communication were competence and proficiency, conveying meaning and understanding others. Levels of small-group anxiety were significantly related to the source of anxiety. Learners with a high level of anxiety were twice as likely to cite interaction as the source of their anxiety than learners with a low level of anxiety.DiscussionThe results suggest that interaction anxiety may be more salient than foreign language anxiety when language learners work in small groups, and that the impact of this form of social anxiety needs to be taken into consideration for learners to fully receive the benefits of group work.
A genome-wide association study identifies genetic determinants of hemoglobin glycation index with implications across sex and ethnicity
Authors: House John S. , Breeyear Joseph H. , Akhtari Farida S. , Evans Violet , Buse John B. , Hempe James , Doria Alessandro , Mychaleckyi Josyf C. , Fonseca Vivian , Shi Mengyao , Li Changwei , Liu Shuqian , Kelly Tanika N. , Rotroff Daniel , Motsinger-Reif Alison A. 
Published: October 2024

IntroductionWe investigated the genetic determinants of variation in the hemoglobin glycation index (HGI), an emerging biomarker for the risk of diabetes complications.MethodsWe conducted a genome-wide association study (GWAS) for HGI in the Action to Control Cardiovascular Risk in Diabetes (ACCORD) trial (N = 7,913) using linear regression and additive genotype encoding on variants with minor allele frequency greater than 3%. We conducted replication analyses of top findings in the Atherosclerosis Risk in Communities (ARIC) study with inverse variance-weighted meta-analysis. We followed up with stratified GWAS analyses by sex and self-reported race.ResultsIn ACCORD, we identified single nucleotide polymorphisms (SNPs) associated with HGI, including a peak with the strongest association at the intergenic SNP rs73407935 (7q11.22) (P = 5.8e−10) with a local replication in ARIC. In black individuals, the variant rs10739419 on chromosome 9 in the Whirlin (WHRN) gene formally replicated (meta-P = 2.2e−9). The SNP-based heritability of HGI was 0.39 (P&lt; 1e−10). HGI had significant sex-specific associations with SNPs in or near GALNT11 in women and HECW2 in men. Finally, in Hispanic participants, we observed genome-wide significant associations with variants near USF1 and NXNL2/SPIN1.DiscussionMany HGI-associated SNPs were distinct from those associated with fasting plasma glucose or HbA1c, lending further support for HGI as a distinct biomarker of diabetes complications. The results of this first evaluation of the genetic etiology of HGI indicate that it is highly heritable and point to heterogeneity by sex and race.
The influence of pragmatic function on children's comprehension of complex because- and if-sentences
Authors: Lemen Heather C. P. , Lieven Elena V. M. , Theakston Anna L. 
Published: October 2024

IntroductionIn complex adverbial sentences, the connectives because and if can perform different pragmatic functions (e.g. Content, Speech-Act), although this is often overlooked in studies investigating children's acquisition of these connectives. In this study, we investigated whether pragmatic variation is responsible for some of the difficulty young children have in understanding because- and if-sentences and tested the extent to which patterns of acquisition are related to the cognitive complexity or input frequency of the different pragmatic types.MethodsNinety-two children (aged 3–5; F = 39) and 20 adults (F = 12) took part in a forced-choice picture task where they had to identify correct pictures after hearing Content and Speech-Act because- and if-sentences.ResultsResults showed that children were most accurate on the sentence type where cognitive simplicity and input frequency converge (If Content), but this pattern was largely driven by the girls in the study. For response times, children were fastest with the least cognitively complex sentence types. However, for because Speech-Act sentences, there was an inverse relationship between response time and input frequency.DiscussionTaken together, these findings suggest that neither account (cognitive complexity or input frequency) can fully explain the findings. Instead, we suggest that the relative contributions of both factors are best understood in terms of the relevance of these utterances to children and the precise contexts in which children hear these utterances produced.
Time dependent changes in protein expression induced by intermittent theta burst stimulation in a cell line
Authors: Ismail Fatima Y. , Krishnan Manigandan , Jayaraj Richard L. , Bru-Mercier Gilles , Pessia Mauro , Ljubisavljevic Milos R. 
Published: October 2024

BackgroundIntermittent Theta Burst Stimulation (iTBS), a non-invasive brain stimulation technique, is recognized for its ability to modulate cortical neuronal activity. However, its effects over time and the dynamics following stimulation are less well understood. Understanding the temporal dynamics of iTBS effects is essential for optimizing the timing and frequency of stimulation in therapeutic applications.ObjectiveThis study investigated the temporal changes in protein expression induced by iTBS in Neuro-2a cells.MethodsWe analyzed protein expression in retinoic acid-differentiated Neuro-2a cells at multiple time points — 0.5, 3, 6, 12, and 24 hours post-iTBS — using Western blot and immunocytochemistry techniques.ResultsOur findings reveal a significant early increase in neurotransmitter receptor subunits, neurotrophic factors, and cytoskeletal proteins within the first 0.5 hour following iTBS. Notably, proteins such as mGLuR1, NMDAR1, GABBR2, and β-tubulin III showed substantial increase in expression. However, the effects of iTBS on protein expression was not sustained at later timepoints.ConclusionOur results suggest that iTBS can transiently alter the expression of specific proteins in Neuro-2a cells. Future research should investigate the potential benefits of repeated stimulations within the early time window to refine iTBS interventions, potentially expanding their research and clinical applications.