bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ethical issues of organ donation after cardiac death
Authors: Reznik O. N. , Skvortcov A. E. , Popova O. V. 
Published: September 2018

There is renewal of interests to the organs that could be obtained from asystolic donors. Our goal was to identify ethical issues raised by attempts of classification and terms such kind of organ donors depended on time and place of cardiac arrest. Based only on the reasoning of medical experts group these principles going to be routine State policy. That followed by erased roles of physicians and misleading the meaning or organ transplant program. From our point of view there should be clear opposite position between death and life in order to initiate organ procurement activity. That is possible only in case of artificial blood supply for preserving transplant-to-be-organs after relevant time between cardiac arrest and start of such kind of perfusion procedure.
The dynamics of pre-existing anti-HLA antibodies and the results of kidney transplantation
Authors: Vatazin A. V. , Zulkarnaev A. B. , Stepanov V. A. , Fedulkina V. A. 
Published: September 2018

Aim. To analyze the relationship between the peak panel-reactive antibodies (peak-PRA), the value at the time of transplantation (Tx-PRA) and the results of kidney transplantation.Materials and methods. The study included 287 patients from the waiting list with anti-HLA antibodies of I and/or II classes. 142 patients underwent transplantation of a cadaveric kidney. All patients received standard immunosuppression: a calcineurin inhibitor, mycophenolate and steroids. Desensitization in the preoperative period was carried out in 11 patients. Screening and identification of antibodies was performed using multiplex technology on Luminex platform.Results. The median PRA was 47% (interquartile range – 29%; 65%). Depending on the dynamics of PRA, we identified several groups of patients: stable PRA (83 patients), increasing (77 patients) or decreasing value (96 patients), or variable dynamics (31 patients). The change in PRA was accompanied by a change in the mean fluorescence intensity (r = 0.787, r2 = 0.59, p < 0.0001). In the univariate analysis, each 5% of peak-PRA and Tx-PRA increased the relative risk (RR) of humoral graft rejection (1.09 (95%CI 1.06; 1.17), p < 0.001; 1.17 (95%CI 1.09; 1.26), p < 0.001 respectively), and ΔPRA decreased a RR (0.932 (95% CI 0.861; 0.967), p = 0.009). In multivariate analysis (adjusted for sex and age of recipient, duration of dialysis, number of HLA mismatches), we observed a similar scenario: peak-PRA 1.14 (95% CI 1.07; 1.19), p < 0.001; Tx-PRA 1.13 (95% CI 1.09; 1.22), p < 0.001; ΔPRA 0.949 (95% CI 0.871; 0.981), p = 0.017. In the univariate analysis increases in peak- PRA and Tx-PRA increased aRR of graft loss (1.1 (95% CI 1.05; 1.14), p < 0.001; 1.09 (95% CI 1.05; 1.15), p < 0.001 respectively), and increase in ΔPRA decreased RR (0.952 (95% CI 0.891; 0.97), p = 0.011). In the adjusted multivariate model, Tx-PRA did not increasea RR of graft loss (1.04 (95% CI, 0.95; 1.1), p = 0.098), while peak-PRA and ΔPRA remained significant factors (1.1 (95% CI, 1.17; 1.24), p < 0.001; 0.931 (95% CI, 0.855; 0.954), p = 0.007, respectively). Conclusion. In the selection donor-recipient pair it is necessary to take into account the spectrum of antibodies at the point of peak values of PRA. A decrease in PRA may hide antibodies that have a specificity to donor antigens or on certain epitope.
The optimization of an accomodation in the thoracic cavity child the axial pump don-3 (the mathematical model research)
Authors: Kozlov V. A. , Dmitrieva O. Yu. , Itkin G. P. , Ivanov A. S. , Kuleshov A. P. , Volkova E. A. , Govorova T. N. 
Published: September 2018

We have developed and tested a technique for constructing 3D models of the chest and thoracic cavity organs. Due to the obtained results, the mathematical model was successfully used in the development of classification of variants of placement of implantable auxiliary circulation systems, and also for building 3D models for other purposes. In particular, the patients were graded according to the variants of placing the children’s axial pump DON-3 inside the patient’s chest cavity. Based on the data, the first fitting of the DON-3 pump was performed on a patient aged 7 years.
Analysis of polymorphisms in the TPMT gene in children with acute leukemia in the Krasnoyarsk Territory
Authors: Karnyushka A. A. , Subbotina T. N. , Shaikhutdinova R. V. , Borisova M. V. , Lobanova S. M. , Kadricheva T. G. , Abel N. A. , Bulava T. I. , Karavaeva E. A. , Guseynova E. A. , Okladnikova L. M. 
Published: September 2018

Introduction.Leukemia accounts for 40 % of all malignant neoplasms under the age of 15 years in children. Determination of the genetic portrait of patients with acute lymphoblastic leukemia (ALL) helps to identify polymorphisms in the genes responsible for the metabolism of drugs included in standard treatment protocols.Materials and methods.51 children with confirmed diagnosis of acute lymphoid leukemia (ALL) were included in the analysis of the frequency of polymorphism of TPMT gene. The detection of polymorphisms TPMT*2, TPMT*3A and TPMT*3 was performed using a set of reagents “AmpliSens® Pyroskrin” & “FARMA-screen-2b”.Results.Polymorphisms in the TPMT gene of 51 patients were found in 6 (11.8 %) children. Of these, 4 patients have variant alleles TPMT*3A and TPMT*3C and 2 patients have only TPMT*3C. Of the 6 patients with TPMT polymorphism, two have a translocation t(12;21).
Kolona metalik stent yerleştirilmesi; 7 yıllık deneyim
Authors: ÖZTAŞ Erkin , AKPINAR Muhammet Yener , DİŞİBEYAZ Selçuk , ÖDEMİŞ Bülent , PARLAK Erkan 
Published: September 2018

Giriş ve Amaç: Kendiliğinden genişleyebilen metalik stentler kolonun benign ve malign bir çok hastalığında giderek artan sıklıkta kullanılmaktadır. Malign
ve benign darlıklar, kaçaklar ve perforasyonlar en sık görülen kullanım
endikasyonlarıdır. Bu çalışmada amacımız kolona kendiliğinden genişleyebilen
metalik stent yerleştirmiş olduğumuz hastaların verilerini retrospektif olarak
değerlendirmektir. Gereç ve Yöntem:
Türkiye Yüksek İhtisas Eğitim ve
Araştırma Hastanesinde 2010-2017 yılları arasında kolona kendiliğinden
genişleyebilen metalik stent yerleştirilen hastaların verileri retrospektif
olarak incelendi. Hastalara kolon stentleri 2 farklı teknik kullanılarak
yerleştirildi. Distal lezyonlarda kılavuz tel üzerinden yalnızca floroskopi
yardımıyla, proksimal lezyonlarda ise kolonoskopun terapötik kanalından kendiliğinden
genişleyebilen metalik stent geçirilerek endoskop ve floroskop birlikte
kullanılarak yerleştirildi.Bulgular: Çalışmaya toplam 41 hasta alındı (yaş ortancası: 63,6,
erkek/kadın: 28/13). 40 hastaya kolonik obstrüksiyon, 1 hastaya ise anastomoz
kaçağı nedeniyle kendiliğinden genişleyebilen metalik stent yerleştirildi. Kolonik
obstrüksiyonu olan hastaların 36 tanesinde neden kolorektal kanserken diğer 4
hasta benign nedenlere bağlı darlık gelişmişti. Genel olarak bakıldığında
teknik başarı oranı %82, klinik başarı oranı ise %96 olarak izlendi. Toplam 4
hastada komplikasyon geliştiği görüldü; iki hastada erken dönemde perforasyon
ve migrasyon gelişti. Diğer iki hastada geç dönemde reobstrüksiyon geliştiği
görüldü.

Tartışma: Kolonik metal stentlerin yüksek teknik ve klinik
başarıları ve düşük komplikasyon oranları, bu stentleri uygun endikasyonu olan
hastalarda önemli bir tedavi modalitesi haline getirmiştir. Bu nedenle sadece
kolorektal kanserde değil, anastomoz darlıklarında ve kaçaklarında da kolonik
metal stentlerin önemli bir tedavi metodu olduğu akılda tutulmalıdır.
La Gitanilla y The Bohemian Girl: La trayectoria musical de un tema cervantino.
Authors: Pérez Fernández Julián Jesús 
Published: September 2018

El artículo recoge, como tema central, la proyección que tuvo la novela corta La Gitanilla de Cervantes en una ópera del siglo XIX:The Bohemian Girl, del compositor irlandés Michael William Balfe, con libreto de Alfred Bunn. Comienza con una visión general sobre lo que se conoce como sueño romántico, es decir, cómo se veía a España en el siglo XIX fuera de nuestras fronteras, con ejemplos tomados de la literatura. Seguidamente nos acercamos a la ciudad de Sevilla como punto de encuentro para muchas óperas y como marco para la creación de algunos mitos de la cultura universal. Después de centrarnos en la novela cervantina como fuente de inspiración para la ópera de Balfe, nos acercamos a una presentación de dicha obra desde la perspectiva de su éxito inicial, su posterior olvido y los intentos actuales de recuperación. Continuamos con una comparación entre las protagonistas de las dos obras (Preciosa y Arline). Unas reflexiones finales cierran este trabajo.
El calamar Emiliano baila Mambo
Authors: Bittini Alegre Antonio 
Published: September 2018

Espectáculo para títeres, guiñoles y teatro de objetos: El escenario consiste en una mesa con iluminación cenital que va cambiando de color según las peripecias del calamar. Sobre la mesa, una caja cerrada, que se abrirá en su momento, y un cajetín con varios objetos. El titiritero maneja los objetos de la mesa y luego pasa al teatrillo de títeres para continuar la historia.
Upaya Peningkatan Minat Belajar Siswa pada Pokok Bahasan Penyetaraan Persamaan Reaksi Kimia Sederhana Melalui Metode Telunjuk Kanan dan Telunjuk Kiri di Kelas X-D MAN 3 Banjarmasin Tahun 2014/2015
Authors: Chairunnisa Chairunnisa 
Published: September 2018

Telah dilakukan penelitian tindakan kelas dengan tujuan untuk meningkatkan pemahaman dan respon siswa kelas X – D MAN 3 Banjarmasin terhadap mata pelajaran kimia pada pokok bahasan penyetaraan persamaan reaksi sederhana.Penelitan tindakan kelas ini menggunakan metode telunjuk kanan dan telunjuk kiri. Subyek penelitian siswa kelas X-D MAN 3 Banjarmasin sebanyak 38 orang, yang terdiri dari 13 orang siswa dan 25 orang siswi. Penelitian dilaksanakan dari bulan Oktober 2014 sampai Januari 2015 didukung dengan dua orang guru kimia yang mengajar di kelas berbeda bertindak sebagai pengamat (observer). Data yang dikumpulkan melalu teknik tes dan non tes dan analisis menggunakan uji presentase.Hasil penelitian menunjukan bahwa pada siklus 1 kemampuan guru menerapkan metode telunjuk kanan dan telunjuk kiri pada pokok bahasan penyetaraan persamaan reaksi sederhana adalah baik dan ada peningkatan pemahaman siswa. Ketuntasan belajar pada siklus I secara klasikal mencapai 70,75 %, sedangkan siklus II mencapai 97,20 %. Selain itu, terdapat peningkatan keterampilan kooperatif terutama kemampuan siswa untuk melakukan hubungan sosial seperti mau bertanya pada orang lain, menghargai pendapat orang lain, mau menerima saran orang lain dan mau menyumbangkan ilmu, yang sebelum tindakan kurang mampu dan setelah dilakukan tindakan menjadi sangat mampu.
Pemanfaatan Limbah Serbuk Gergaji Ulin dan Kayu Biasa Sebagai Energi Alternatif Pengganti Bahan Bakar Minyak
Authors: Chairunnisa Chairunnisa 
Published: September 2018

Konsumsi bahan bakar di Indonesia telah melebihi produksi dalam negeri. Dalam kurun waktu 10-15 tahun ke depan cadangan rainyak bumi Indonesia diperkirakan akan habis. Oleh karena itu, usaha untuk mencari bahan bakar alternatif yang dapat diperbaharui (renewable), ramah lingkungan dan bernilai ekonomis, semakin banyak dilakukan. Limbah industri kayu dan pertanian seperti serbuk gergaji ulin dan serbuk gergaji kayu biasa yang banyak terdapat di Banjarmasin belum termanfaatkan sepenuhnya. Proses pembuatan briket diawali dengan cara mengeringkan serbuk gergaji ulin maupun serbuk gergaji kayu biasa di bawah terik matahari untuk mengurangi kadar airnya. Hasil penelitian menunjukkkan dengan massa yang sama, briket biasa maupun briket arang yang dari serbuk gergaji ulin lebih baik dari serbuk gergaji kayu biasa, karena menunjukkkan waktu yang paling lama dan nyala api yang lebih stabil serta lebih ramah lingkungan dan dapat digunakan sebagai bahan bakar alternatif pengganti bahan bakar minyak.
Pendidikan Islam Berbasis IESAQ
Authors: Hasanah Mila 
Published: September 2018

Problematika pendidikan diantaranya adalah terlalu berorientasi kepada aspek kognitif saja, kurang memperhatikan aspek IESAQ. Pendidikan Islam berbasis IESAQ, ditawarkan pada artikel ini dengan metode penelitian kepustakaan. IESAQ yang mengintegrasikan dan memadukan pengembangan aspek intelektual, emosional, spritual dan Adversity Quotient dilingkungan pendidikan. Mampu menikmati proses menuju keberhasilan walau mereka tahu bahwa akan banyak rintangan dan kesulitan yang menghadang. Namun, di balik kesulitan itu ia akan mendapatkan banyak kemudahan. Strategi Meningkatkan IESAQ: melalui pengalaman kegiatan intelektual, pengalaman terstruktur dan puasa, safar, zikr, kontemplasi , zuhud dan jihad. Atau dengan strategi tathahhur yaitu pembiasaan taat syari’at, muhasabah, mujahadah dan riyadhah al-nafs.
Anestesi Tetes Infus Gravimetrik Ketapol sebagai Alternatif Bius Umum Secara Inhalasi Guna Menjaga Status Teranestesi pada Babi
Authors: Pemayun I Gusti Agung Gde Putra , Sudisma I Gusti Ngurah 
Published: September 2018

This study aim was to evaluate quality and effectiveness of anaesthesia by using gravimetric infusion anaesthesia with ketamine and propofol (ketafol) on pigs. The quality of anesthesia time, the cardiovascular and respiratory response of anaesthesia were evaluated in twelve male pigs with average body weight 35±5 kg. The pigs were divided into four treatments and each treatment consisted of three pigs as repetition. All the experimental animals were premedicated with atropine 0.03 mg/kg mixed with xylazine 2 mg/kg in one syringe injected intramuscularly. Fifteen minutes after premedicated, the pigs was induced intravenously with ketamine 6 mg/kg and propofol 2 mg/kg. Furthermore, the anesthetized state maintaned with gravimetric, each through infusion with propofol (0.1 mg/kg/minute) (PI-P) , ketamine (0.3 mg/kg/ minute) (PIK), combination propofol-ketamin (0.1 and 0.3 mg/kg/minute) (PI-PK), and inhalation with isoflurane 1-2% (PI-I). The heart rate, pulse, respiratory rate, rectal temperature, blood oxygen saturation (SpO2 ), capillary refill time (CRT) were observed before and after treatment of the anesthetic. Premedication combination of atropin 0.03mg/kg mixed with xylazine 2 mg/kg in one syringe and then induced with ketamine 6 mg/kg and propofol 2 mg/kg showed the average length of anesthesia for 32,33 minutes, longer compared to five other treatments with average length of induction three minutes and average recovery time 20.33 minutes. Maintenance of anesthesia with propofol infusion drops (0.1 mg/kg/minute), or propofolketamine infusion drops (0.3 and 0.1 mg/kg/minute) showed safer anesthesia, because they did not make drastic change of heart rate, respiratory rate, rectal temperature, oxygen saturation, pulse, and CRT value in the experimental pigs. The conclusion of this study is the methode of gravimetric intravenous infusion by using ketamine and propofol (ketafol) can be used to maintain anesthesia as an alternative general inhalation anaesthesia in pigs.
Yb:CALYO-based femtosecond chirped pulse regenerative amplifier for temporally resolved pump-probe spectroscopy
Authors: Rudenkov A. S. , Kisel V. E. , Yasukevich A. S. , Hovhannesyan K. L. , Petrosyan A. G. , Kuleshov N. V. 
Published: September 2018

Diode-pumped femtosecond chirped pulse regenerative amplifiers based on Yb3+-materials are of practical importance for wide range of scientific, industrial and biomedical applications. The aim of this work was to study the amplification of broadband chirped femtosecond pulses in regenerative amplifier based on Yb3+:CaYAlO4crystal.Such systems use femtosecond mode-locked lasers as seed pulse sources and amplify nJ-seed pulses to sub-mJ energy range. Most chirped pulse regenerative amplifier systems described in the literature use seed lasers with typical pulse spectral width at the level of 10–15 nm full width at half maximum (FWHM) that limit the seed pulse duration of about 90 fs and amplified pulse duration at the level of 200 fs due to strong influence of gain narrowing effect on the amplified pulse parameters. Yb3+-doped crystals with wide and smooth gain bandwidth as an active medium of chirped femtosecond pulse regenerative amplification systems allow to reduce negative contribution of gain narrowing effect and lead to shortening of amplified pulses. In this research we study the chirped pulse regenerative amplification of broad-band femtosecond pulses (60 nm spectral width FWHM) in the Yb3+:CaYAlO -based chirped pulse regenerative amplifier. Substantial reduction of the amplified pulse duration down to 120 fs (19.4 nm spectral width FWHM) with average power of 3 W at 200 kHz pulse repetition frequency was demonstrated without any gain narrowing compensation technique.The results of experimental investigation of broad-band seeded Yb3+:CaYAlO -based chirped pulse regenerative amplifier are reported for the first time to our knowledge. 120 fs-pulses (19.4 nm FWHM) with average output power of 3 W were demonstrated without any gain narrowing compensation technique. Despite the significant reduction of amplified pulse duration the task of improvement group velocity dispersion balance (including high orders of group velocity dispersion) remains relevant.
Measuring transducers for optical diagnostic system with multifunctional unitary photovoltaic converters
Authors: Vorobei R. I. , Gusev O. K. , Svistun A. I. , Tyavlovsky A. K. , Tyavlovsky K. L. , Shadurskaya L. I. 
Published: September 2018

Modern measuring transducers for optical diagnostic system should perform automatic parameter estimation of optical signal and automatic switching between different energetic and optical sensitivity ranges. Traditional solution of this problem lies in the field of multi-sensory systems, complex optical schemes and complex signal processing algorithms. The paper aims at the development of new measuring transducers for optical diagnostic system on a basis of multifunctional unitary photovoltaic converters built on semiconductors with low-concentration deep dopants that form multiple energy levels for different charge states in the band gap. Relative complexity of physical processes accompanying the recharge of several energy levels of multiply-charged deep dopant makes it possible to realize the multifunctionality of a photoelectric converter albeit simple sensor design.The proposed unitary photovoltaic converters proved to have extended functional characteristics and increased ranges of energetic characteristic (by dozens dB) and spectral sensitivity characteristic with possible shifts of red margin by 2 to 4 μm in the spectral sensitivity range of 1–10 μm. Energetic and spectral sensitivity characteristic ranges could be switched either by measurement signal itself or by additional control inputs. Possible materials for resistive or barrier photovoltaic converter structure are Germanium, Silicon, А3В5 systems and other semiconductors including that compatible with «non-silicon» technologies and structures on sapphire substrate.
Simulation of cathode surface sputtering by ions and fast atoms in Townsend discharge in argon-mercury mixture with temperature-dependent composition
Authors: Bondarenko G. G. , Kristya V. I. , Savichkin D. O. , Żukowski P. 
Published: September 2018

The mixture of argon and mercury vapor is used as the background gas in different types of gas discharge illuminating lamps. The aim of this work was development of a model, describing transport of electrons, ions and fast atoms in the one-dimensional low-current gas discharge in argon-mercury mixture, and determination of the dependence of their contributions to the cathode sputtering, limiting the device service time, on the temperature.For simulation of motion of electrons we used the Monte Carlo method of statistical modeling, whereas the ion and metastable excited atom motion, in order to reduce the calculation time, we described on the basis of their macroscopic transport equations, which allowed to obtain their flow densities at the cathode surface. Then, using the Monte Carlo method, we found the energy spectra of ions and fast atoms, generated in collisions of ions with mixture atoms, at the cathode surface and also the effective coefficients of the cathode sputtering by each type of particles.Calculations showed that the flow densities of argon ions and fast argon atoms, produced in collisions of argon ions with slow argon atoms, do not depend on the temperature, while the flow densities of mercury ions and fast argon atoms generated by them grow rapidly with the temperature due to an increase of mercury content in the mixture.There are represented results of modeling of the energy spectra of ions and fast atoms at the cathode surface. They demonstrate that at low mercury content in the mixture of the order of 10–3 the energies of mercury ions exceed that of the other types of particles, so that the cathode is sputtered mainly by mercury ions, and their contribution to sputtering is reduced at a mixture temperature decrease.
Recent Advances in Azole Based Scaffolds as Anticandidal Agents
Authors: Gurubasavaraj Prabhuodeyara Math , Charantimath Jasmith Shivayya 
Published: September 2018

Aim:The present review aims to explore the development of novel antifungal agents, such as pharmacology, pharmacokinetics, spectrum of activity, safety, toxicity and other aspects that involve drug-drug interactions of the azole antifungal agents.Introduction:Fungal infections in critically ill and immune-compromised patients are increasing at alarming rates, caused mainly by Candida albicans an opportunistic fungus. Despite antifungal annihilators like amphotericin B, azoles and caspofungin, these infections are enormously increasing. The unconventional increase in such patients is a challenging task for the management of antifungal infections especially Candidiasis. Moreover, problem of toxicity associated with antifungal drugs on hosts and rise of drug-resistance in primary and opportunistic fungal pathogens has obstructed the success of antifungal therapy.Conclusion:Hence, to conflict these problems new antifungal agents with advanced efficacy, new formulations of drug delivery and novel compounds which can interact with fungal virulence are developed and used to treat antifungal infections.