bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fuzzy Sliding Mode Control for Active Suspension System with Proportional Differential Sliding Mode Observer
Authors: Lin Bin , Su Xiaoyu , Li Xiaohang 
Published: August 2018

AbstractIn this paper, a generalized augmented transformation is considered for the quarter active suspension system with uncertainties. Specifically, the model uncertainties are converted to the augmented states and a new proportion differential sliding mode observer is used to estimate state variables and model uncertainties. A differential geometric method is applied to linearize the nonlinear suspension model. In order to weaken the vibration effect of sliding mode control force and reduce energy consumption, a fuzzy sliding mode controller is designed for the active suspension system and the fuzzy controller is applied to adjust switching control gain according to the reaching condition of sliding mode surface. The simulations are conducted to illustrate the effectiveness and advantages of this proposed observer and control strategy.
Trends, correlates, and survival of infants with congenital diaphragmatic hernia and its subtypes
Authors: Ramakrishnan Rema , Salemi Jason L. , Stuart Amy L. , Chen Henian , O'Rourke Kathleen , Obican Sarah , Kirby Russell S. 
Published: August 2018

ObjectiveTo identify the live‐birth prevalence, trends, correlates, and neonatal and 1‐year survival rates of congenital diaphragmatic hernia.MethodsUsing a population‐based, retrospective cohort study design, we examined 1,025 cases of congenital diaphragmatic hernia from the 1998–2012 Florida Birth Defects Registry. We used Poisson and joinpoint regression models to compute prevalence ratios and temporal trends, respectively. Kaplan–Meier survival curves and Cox proportional hazards regression were used to describe neonatal and 1‐year survival and estimate hazard ratios representing the predictors of infant survival.ResultsThe birth prevalence of congenital diaphragmatic hernia was 3.19 per 10,000 live births (95% confidence interval [CI]: 3.00–3.39); there was a 4.2% yearly increase among multiple cases only. Among all cases, maternal education less than high school (prevalence ratio: 1.25, 95% CI: 1.02–1.53), high school/associate degree/GED (prevalence ratio: 1.15, 95% CI: 1.01–1.32), multiple birth (prevalence ratio: 1.38, 95% CI: 1.05–1.81), and male sex (prevalence ratio: 1.18, 95% CI: 1.05–1.32) were associated with increased risk for congenital diaphragmatic hernia. The 24‐hr, neonatal, and 1‐year survival rates were 93.6%, 79.8%, and 71.2%, respectively. The highest hazard ratio of 17.87 (95% CI: 1.49–213.82) was observed for neonatal mortality among cases associated with chromosomal anomalies and born <37 weeks at < 1,500 g. Among isolated cases, multiple birth (hazard ratio: 0.41, 95% CI: 0.20–0.86) was associated with decreased 1‐year mortality.ConclusionLow maternal education and multiple birth may be linked to congenital diaphragmatic hernia. The trends in prevalence, epidemiologic correlates, and predictors of early survival can differ between congenital diaphragmatic hernia subtypes—isolated, multiple, and chromosomal.© 2018 Wiley Periodicals, Inc. © 2018 Wiley Periodicals, Inc.
A case study of the challenges for an integrative practitioner learning a new psychological therapy
Authors: Byrne Angela , Salmon Peter , Fisher Peter 
Published: August 2018

AbstractBackgroundMany psychotherapy practitioners draw from several psychotherapeutic models in an effort to maximise the help they can give to individual patients. Such “integrative” practice is promoted by training that typically encompasses multiple models, but might impair practitioners’ ability to learn any single approach proficiently.AimsOne way to identify the influence of integrative practice on therapists’ ability to learn a new approach is by examining the challenges that arise when a psychotherapist, previously socialised into the integrative approach, tries to learn a new single approach. Here we describe the experience of the first author, a clinical psychologist being supervised by the last author, to make the transition from an integrative way of working to a single approach.MethodIn a single case of post‐qualification training, we aimed to identify the influence of the integrative approach to clinical practice by analysing the challenges that arose when one experienced clinical psychologist was supervised with the aim to reach competence in an unfamiliar psychotherapeutic model: metacognitive therapy. The present paper is based on the experience of the training period, documented contemporaneously by the supervisee and supervisor and analysed subsequently in discussion amongst all authors.ResultsThe challenges included learning to adhere to the model consistently, resisting previous habits of engaging with the content of patients’ distress, dismantling beliefs about the nature and importance of therapeutic relationship, and learning not to interpret patient improvement as indicating therapeutic competence.ConclusionsThese challenges reflect fundamental weaknesses of the integrative approach that characterise current psychotherapy training in the USA and more generally and highlight implications for how training and supervision might be strengthened to ensure psychotherapists’ competence.
Preparation and investigation of indirubin‐loaded SLN nanoparticles and their anti‐cancer effects on human glioblastoma U87MG cells
Authors: Rahiminejad Ali , Dinarvand Rassoul , Johari Behrooz , Nodooshan Saeedeh Jafari , Rashti Ali , Rismani Elham , Mahdaviani Parvin , Saltanatpour Zohreh , Rahiminejad Sajad , Raigani Mozhgan , Khosravani Masood 
Published: August 2018

AbstractIndirubin, an ingredient in traditional Chinese medicine, is considered as an anti‐cancer agent. However, due to its hydrophobic nature, clinical efficiency has been limited. Drug delivery via nanotechnology techniques open new windows toward treatment of cancerous patients. Glioblastoma multiforme (GBM) is the most severe and common type of brain primary tumors. Of common problems in targeting therapies of glioblastoma is the availability of drug in tumoric tissues. In this study, Indirubin loaded solid lipid nanoparticles were prepared and their therapeutic potentials and antitumoric effects were assessed on GBM cell line (U87MG). The SLNs were prepared with Cetyl palmitate and Polysorbat 80 via high‐pressure homogenization (HPH) methods in hot mode. Then, properties of SLNs including size, zeta potential, drug encapsulation efficacy (EE %) and drug loading were characterized. SLNs morphology and size were observed using SEM and TEM. The crystalinity of formulation was determined by different scattering calorimetry (DSC). The amount of drug release and antitumor efficiency were evaluated at both normal brain pH of 7.2 and tumoric pH of 6.8. The prapared SLNs had mean size of 130 nm, zeta potential of −16 mV and EE of 99.73%. The results of DSC showed proper encapsulation of drug into SLNs. Drug release assessment in both pH displayed sustain release property. The result of MTT test exhibited a remarkable increment in antitumor activity of Indirubin loaded SLN in comparison with free form of drug and blank SLN on multiform GB. This study indicated that Indirubin loaded SLNs could act as a useful anticancer drugs.
Yeast dynamin and Ypt6 function in parallel for the endosome‐to‐Golgi retrieval of Snc1
Authors: Makaraci Pelin , Delgado Cruz Mariel , McDermott Hyoeun , Nguyen Vy , Highfill Chad , Kim Kyoungtae 
Published: August 2018

AbstractProtein recycling is an important cellular process required for cell homeostasis. Results from prior studies have shown that vacuolar sorting protein‐1 (Vps1), a dynamin homolog in yeast, is implicated in protein recycling from the endosome to the trans‐Golgi Network (TGN). However, the function of Vps1 in relation to Ypt6, a master GTPase in the recycling pathway, remains unknown. The present study reveals that Vps1 physically interacts with Ypt6 if at least one of them is full‐length. We found that overexpression of full‐length Vps1, but not GTP hydrolysis‐defective Vps1 mutants, is sufficient to rescue abnormal phenotypes of Snc1 distribution provoked by the loss of Ypt6, and vice versa. This suggests that Vps1 and Ypt6 function in parallel pathways instead of in a sequential pathway and that GTP binding/hydrolysis of Vps1 is required for proper traffic of Snc1 toward the TGN. Additionally, we identified two novel Vps1‐binding partners, Vti1 and Snc2, which function for the endosome‐derived vesicle fusion at the TGN. Taken together, the present study demonstrates that Vps1 plays a role in later stages of the endosome‐to‐TGN traffic.
ERK1/2 and JNK signaling synergistically modulate mitogenic effect of fibroblast growth factor 2 on liver cell
Authors: Wu Shiyong , Zhang Wenhua , Ma Shumin , Li Bin , Xu Chanjuan , Yi Ping 
Published: August 2018

AbstractProliferation of the adult hepatocyte population represents a central feature of tissue regeneration after liver injury and resection. This process could be driven by a diverse range of mitogens, such as hepatocyte growth factor (HGF) and fibroblast growth factor (FGF). Among FGF family, FGF2 is closely related to wound repair and cell proliferation. FGF2 does function in the process of angiogenesis in regenerating liver, while fewer reports are concerned with the impact and underlying mechanism of FGF2 on liver cell proliferation. To this end, an immortalized human normal hepatocyte L02 and mouse primary hepatocytes were exposed to FGF2 in this study. We demonstrate that FGF2 significantly enhances liver cell proliferation. Treatment with FGF2 obviously increases the phosphorylation level of extracellular signal‐regulated kinases 1 and 2 (ERK1/2) and c‐Jun N‐terminal kinase (JNK). Activity inhibition or expression down‐regulation prove that both ERK1/2 and JNK signaling are required for FGF2‐mediated effect on liver cell proliferation. Interestingly, interfering of ERK1/2 signaling results in marked decrease of JNK activation under FGF2 treatment, and JNK signaling is also involved in regulation of FGF2‐induced ERK1/2 activation, suggesting that cross‐talk between ERK1/2 and JNK signaling is important for FGF2 mitogenic activity. Both ERK1/2 and JNK signal via CREB to function in proliferation impact of FGF2 on liver cells. Taken together, this study reveals that ERK and JNK pathways synergistically regulate FGF2‐induced liver cell proliferation via phosphorylating CREB, which will contribute to the understanding of FGF2 impact on liver cell proliferation and liver regeneration.
Proliferation, cancer, and aging—novel functions of the nucleolar methyltransferase fibrillarin?
Authors: Shubina Maria Y. , Musinova Yana R. , Sheval Eugene V. 
Published: August 2018

AbstractFibrillarin is an essential nucleolar protein that catalyzes the 2′‐O‐methylation of ribosomal RNAs. Recently, experimental data have begun to accumulate that suggest that fibrillarin can influence various cellular processes, development of pathological processes, and even aging. The exact mechanism by which fibrillarin can influence these processes has not been found, but some experimental data indicate that up‐ or downregulation of fibrillarin can modify the ribosome structure and, thus, causе an alteration in relative efficiency with which various mRNAs are translated. Here, we discuss recent studies on the potential roles of fibrillarin in the regulation of cell proliferation, cancer progression, and aging.
Benefit of routine preprocedural radial artery angiography in STEMI patients
Authors: Zafirovska Biljana , Antov Slobodan , Kostov Jorgo , Spiroski Igor , Vasilev Ivan , Jovkovski Aleksandar , Kitanoski Darko , Petkoska Danica , Bertrand Olivier F. , Kedev Sasko 
Published: August 2018

AbstractAimsTo assess the benefit of routine preprocedural radial artery (RA) angiography in patients with ST segment elevation myocardial infarction (STEMI).Methods and ResultsAll consecutive STEMI patients, in the period from January 2010 until December 2016 were included in the study.Preprocedural radial artery angiography was performed in all patients since March 2011. We compared clinical and procedure characteristics, access site bleeding complications and failure of primary chosen TRA between two groups of STEMI patients before and after we started performing routine RA angiography.We compared 762 STEMI patients from 2010 until March 2011 and 4306 STEMI patients after March 2011 until December 2016. Mean age of patients was 60 ± 11 years with 73% males. The latter group had more elderly and obese patients (P < .0001 both). Prior percutaneous coronary interventions was present in 7% of patients and 0, 1% had prior coronary bypass surgery.Procedure duration (38 ± 16 vs. 32 ± 20 min) was significantly longer in the first group (P value < .0001), but contrast volume (120 ± 33 vs. 110 ± 35 ml), and fluoroscopy time (8.6 ± 6 vs. 8.7 ± 8 min) were similar in both groups. Access crossover from primary TRA was 4, 6% in the first group, with a significant decrease to 3, 1% in the second (P < .0001), after introducing preprocedural RA angiography.Access site bleeding complications were significantly higher in the first group 6.8% vs. 4.3% in the second (p < .0001).ConclusionRoutine preprocedural radial artery angiography in STEMI patients is associated with lower rate of access site bleeding complications and reduced overall procedural time and TRA crossover rate.
Molybdenum Nitride Nanocatalyst Derived from Melamine and Polyoxometalate‐based Hybrid for Oxidative Coupling of Amines to Imines with Air
Authors: Li Yue , Xiao Kang , Li Jingjing , Jiang Pingping , Jiang Yuchen , Du Shengyu , Leng Yan 
Published: August 2018

AbstractMolybdenum nitride (Mo2N) is one of the most promising alternative catalysts for a wide range of Pt‐catalyzed catalytic applications but is seldom investigated in oxidative coupling of amines to imines. A Mo2N‐based nanocatalyst is successfully achieved by the hybridization of PMo12O403− (PMo)‐paired ionic pyridine‐4‐carboxylic acid (PC) and melamine (Mel), followed by calcination in N2. Melamine acts as an outstanding carburization and nitridation reagent that can convert into carbon nitride, and meanwhile the released N element react with Mo species in PMo to form Mo2N. The obtained catalyst PC‐PMo‐Mel‐800 exhibits high activity and remarkable stability for the oxidative coupling of amines to imines under solvent‐free and atmospheric conditions. This is the first case of Mo2N‐catalyzed oxidative coupling reaction catalyst. The strategy reported herein for fabricating Mo2N may provide a significant and interesting approach to design more transition metal nitrides for wide catalytic applications.
A Robust and Scalable Continuous Flow Process for Glycerol Carbonate
Authors: Van Mileghem Seger , De Borggraeve Wim M. , Baxendale Ian R. 
Published: August 2018

AbstractWith glycerol being a bulk waste product, the interest in converting it to other value‐added products is steadily increasing. A scalable continuous flow process was developed for the synthesis of glycerol carbonate (2‐GLC) from glycerol and dimethyl carbonate on a hydroxide functional resin. High conversion and selectivity were obtained while the residence times were typically shorter than 10 min. Continuous production of 2‐GLC was achieved in high throughput and with improved processing metrics, creating the foundations for a production level process.
Simple immersed boundary matrix‐cut‐method for cartesian grids using FV and FD discretizations
Authors: Dierich Frank , Ananiev Sergey , Nikrityuk Petr A. 
Published: August 2018

AbstractThis work presents a means of implementing a simple implicit Cartesian grid matrix‐cut method to model the heat and mass transfer in irregular geometries using any implicit Cartesian grid solver in finite‐volume and finite‐difference formulations. This method allows the precise imposing of Dirichlet, Neumann, and Robin boundary conditions in any internal node of the grid. The main idea of this method comes from a finite element method where the coefficients of the implicit matrix of a discretized equation are modified directly to ensure the consistency of the presence of the boundary conditions at immersed boundaries represented by grid nodes. One of the advantages of this method is its capability to solve a transport equation implicitly in steady and unsteady modes, applied to complex geometry immersed into the Cartesian grid. This method can be easily implemented in any direct matrix solver, e.g., Gauss elimination, or any iterative matrix solver. To validate this method, different cases are considered.
Einflussfaktoren auf chemiebezogene Berufswahlabsichten von Schülerinnen und Schülern
Authors: Spitzer Philipp , Gröger Martin 
Published: August 2018

AbstractIm Zuge des drohenden Fachkräftemangels fordern chemische Industrie und Politik eine stärkere Berufsorientierung für chemische Berufe. In einer Fragebogenstudie mit 1113 Schüler/‐innen der Jahrgangsstufen 8 und 11 wurden daher die aktuelle Umsetzung von Berufsorientierung an Schulen sowie Einflussfaktoren auf eine chemiebezogene Berufswahl unter besonderer Berücksichtigung von Image, Selbstkonzept und Prototypenbeschreibung erhoben. Die berechneten Modelle für die Jahrgangsstufen 8 und 11 zeigen insbesondere Imagevariablen und das chemische Selbstkonzept als Einflussfaktoren auf eine chemiebezogene Berufswahl.Als eine mögliche Interventionsmaßnahme zur Stärkung der Berufsorientierung im Chemieunterricht wird das Chem‐Trucking‐Projekt vorgestellt. Hier bekommen Schüler/‐innen die Möglichkeit, anhand authentischer Problemstellungen umweltanalytische Messungen mit professionellem Equipment vor Ort und im Kontakt mit Experten durchzuführen und so einen chemischen Beruf kennenzulernen.
Left ventricular thrombosis in acute anterior myocardial infarction: Evaluation of hospital mortality, thromboembolism, and bleeding
Authors: Ram Pradhum , Shah Mahek , Sirinvaravong Natee , Lo Kevin Bryan , Patil Shantanu , Patel Brijesh , Tripathi Byomesh , Garg Lohit , Figueredo Vincent 
Published: August 2018

BackgroundLeft ventricular thrombosis (LVT) is a well‐known complication of acute myocardial infarction, most commonly seen in anterior wall ST‐segment elevation myocardial infarction (STEMI). It is associated with systemic thromboembolism.HypothesisOur aim was to evaluate the impact of LVT on in‐hospital mortality, thromboembolism, and bleeding in patients with anterior STEMI.MethodsData was collected from the Nationwide Inpatient Sample where patients with a primary diagnosis of “Anterior STEMI” [ICD9‐CM code 410.1] were included. Comparisons were made between patients with LVT [ICD9‐CM code 429.79] vs those without using propensity score matching (PSM).ResultsFrom 2002 to 2014, there were 157 891 cases of anterior STEMI. Among these, 649 (0.4%) had LVT. Post‐PSM, there was no difference in in‐hospital mortality between the groups with LVT and without (7.3% vs 8.6%). Thromboembolic event rate was higher with LVT compared to those without LVT (7.3% vs 2.1%). There was no difference in bleeding events between patients with LVT and those without (2.9% vs 3.2%). The baseline average length of stay in the group with LVT was longer than the group without LVT (7.9 ± 6.7 days vs 5.1 ± 6.0 days). The average hospitalization‐related costs were also significantly higher among patients with LVT compared to those without (95 598 USD vs 66 641 USD per stay) at baseline.ConclusionAmong patients hospitalized with anterior STEMI, presence of LVT is associated with increased thromboembolic events, average length of hospital stay and average cost of hospitalization. However, it is not associated with increased in‐hospital mortality or bleeding events.
Actin's N‐terminal acetyltransferase uncovered
Authors: Arnesen Thomas , Marmorstein Ronen , Dominguez Roberto 
Published: August 2018

AbstractHumans express six highly conserved actin isoforms, which differ the most at their N‐termini. Actin's N‐terminus undergoes co‐ and post‐translational processing unique among eukaryotic proteins. During translation, the initiator methionine of the two cytoplasmic isoforms is N‐terminally acetylated (Nt‐acetylated) and that of the four muscle isoforms is removed and the exposed cysteine is Nt‐acetylated. Then, an unidentified acetylaminopeptidase post‐translationally removes the Ac‐Met (or Ac‐Cys), and all six isoforms are re‐acetylated at the N‐terminus. Despite the vital importance of actin for cellular processes ranging from cell motility to organelle trafficking and cell division, the mechanism and functional consequences of Nt‐acetylation remained unresolved. Two recent studies significantly advance our understanding of actin Nt‐acetylation. Drazic et al. (2018, Proc Natl Acad Sci U S A, 115, 4399–4404) identify actin's dedicated N‐terminal acetyltransferase (NAA80/NatH), and demonstrate that Nt‐acetylation critically impacts actin assembly in vitro and in cells. NAA80 knockout cells display increased filopodia and lamellipodia formation and accelerated cell motility. In vitro, the absence of Nt‐acetylation leads to a decrease in the rates of filament depolymerization and elongation, including formin‐induced elongation. Goris et al. (2018, Proc Natl Acad Sci U S A, 115, 4405–4410] describe the structure of Drosophila NAA80 in complex with a peptide‐CoA bi‐substrate analog mimicking the N‐terminus of β‐actin. The structure reveals the source of NAA80's specificity for actin's negatively‐charged N‐terminus. Nt‐acetylation neutralizes a positive charge, thus enhancing the overall negative charge of actin's unique N‐terminus. Actin's N‐terminus is exposed in the filament and influences the interactions of many actin‐binding proteins. These advances open the way to understanding the many likely consequences and functional roles of actin Nt‐acetylation.
The brain of the tree pangolin (Manis tricuspis). II. The olfactory system
Authors: Imam Aminu , Bhagwandin Adhil , Ajao Moyosore S. , Spocter Muhammed A. , Ihunwo Amadi O. , Manger Paul R. 
Published: August 2018

AbstractThis study employed a range of neuroanatomical stains to determine the organization of the main and accessory olfactory systems within the brain of the tree pangolin. The tree pangolin has a typically mammalian olfactory system, but minor variations were observed. The main olfactory system is comprised of the layered main olfactory bulb (MOB), the anterior olfactory nucleus (AON), the rostral olfactory cortex (including the taenia tecta, anterior hippocampal continuation and induseum griseum), the olfactory tubercle (Tu), the lateral olfactory tract (lot) and the olfactory limb of the anterior commissure, the nucleus of the lateral olfactory tract (NLOT), the piriform cortex (PIR) and a typically mammalian rostral migratory stream (RMS). The accessory olfactory system included the layered accessory olfactory bulb (AOB) and the nucleus of the accessory olfactory tract (NAOT). Volumetric analysis of the relative size of the MOB and PIR indicate that the tree pangolin has an olfactory system that occupies a proportion of the brain typical for the majority of mammals. Within the MOB, the glomeruli of the tree pangolin, at 200 μm diameter, are larger than observed in most other mammalian species, and the MOB lacks a distinct internal plexiform layer. In addition, the laminate appearance of the NLOT was not observed in the tree pangolin. The accessory olfactory system appears to lack the posterior compartment of the accessory olfactory bulb. These observations are contextualized in relation to olfactory‐mediated behaviors in pangolins.