bluuebunny/crossref_metadata_2025_split huggingface dataset:
Information privacy concern and deception in online retailing
Authors: Li Yang , Liu Hefu , Lee Matthew , Huang Qian 
Published: July 2019

PurposePrevious studies have attempted to address online uncertainties from the relationship marketing perspective. The purpose of this paper is to argue that the integration of media richness theory (MRT) and cognitive fit theory (CFT) can contribute a new perspective in addressing consumers’ transaction-specific uncertainties in online retailing.Design/methodology/approachOn the basis of MRT and CFT, a research model was developed by correlating online channel media richness (OCMR), online–offline information integration (OOII), information privacy concern, perceived deception and online loyalty. The model was empirically examined based on survey data collected from 258 multi-channel consumers in China.FindingsAn analysis of structural equation model showed that OCMR is negatively associated with information privacy concern and perceived deception but is not significant to online loyalty. Information privacy concern has a negative influence on online loyalty, but the effect of perceived deception is not significant. Moreover, information privacy concern is positively related to perceived deception. The OOII strengthens the influence of OCMR but not the moderating effect of integrated promotion, product and price information on the relationship between OCMR and online loyalty.Originality/valueThis study contributes to the extant literature on online retailing by examining the effect of OCMR on online transaction uncertainties. Information integrity in the form of OOII was proposed to complement OCMR. Results have shown that OCMR is significant in reducing online uncertainties, and OOII strengthens this effect, thereby enhancing online loyalty.
Factors influencing teaching as a career choice in both public and private universities in Ghana
Authors: Amoako George Kofi , Dartey-Baah Kwasi , Sokro Evans 
Published: July 2019

PurposeThe purpose of this paper is to explore how lecturers in both public and private universities in Ghana are motivated to take up teaching as a career using Herzberg’s two-factor theory.Design/methodology/approachIn this paper, qualitative research design was adopted. Data were collected from 24 lecturers from both public and private universities in Ghana and analysed with NVivo.FindingsResults from the analysis indicate that public sector university lecturers are generally better motivated than their counterparts at the private sector. Workload is higher at private universities, affecting research and publications negatively. The study also revealed that there are differences in motivation in relation to the hygiene factors between the public and private university teachers.Research limitations/implicationsThis study has a few limitations that must be considered and could provide guidance for future study; as this study addressed faculty point of view, future study could investigate from manager’s and other stakeholders’ point of view in order to get a holistic view of the issues under investigation. The sample size could be improved and the study could be conducted in other African countries for the purposes of comparison.Practical implicationsThe study shows that many lecturers are not happy in the job for both public and private universities. The findings of the study provide managers in the higher education industry with practical guidelines for strategies to motivate lecturers.Originality/valueDespite the rapid growth in the educational industry in Ghana, limited studies have been conducted into how lecturers are motivated to stay in teaching. This makes this research unique in Ghana. This study makes an original contribution by comparing how public sector and private sector university lecturers differ in their motivation to teach at the university using Herzberg’s two-factor theory.
Geomicrobiology of the carbon, nitrogen and sulphur cycles in Powell Lake: a permanently stratified water column containing ancient seawater
Authors: Haas Sebastian , Desai Dhwani K. , LaRoche Julie , Pawlowicz Rich , Wallace Douglas W. R. 
Published: July 2019

SummaryWe present the first geomicrobiological characterization of the meromictic water column of Powell Lake (British Columbia, Canada), a former fjord, which has been stably stratified since the last glacial period. Its deepest layers (300–350 m) retain isolated, relict seawater from that period. Fine‐scale vertical profiling of the water chemistry and microbial communities allowed subdivision of the water column into distinct geomicrobiological zones. These zones were further characterized by phylogenetic and functional marker genes from amplicon and shotgun metagenome sequencing. Binning of metagenomic reads allowed the linkage of function to specific taxonomic groups. Statistical analyses (analysis of similarities, Bray–Curtis similarity) confirmed that the microbial community structure followed closely the geochemical zonation. Yet, our characterization of the genetic potential relevant to carbon, nitrogen and sulphur cycling of each zone revealed unexpected features, including potential for facultative anaerobic methylotrophy, nitrogen fixation despite high ammonium concentrations and potential micro‐aerobic nitrifiers within the chemocline. At the oxic–suboxic interface, facultative anaerobic potential was found in the widespread freshwater lineage acI (Actinobacteria), suggesting intriguing ecophysiological similarities to the marine SAR11. Evolutionary divergent lineages among diverse phyla were identified in the ancient seawater zone and may indicate novel adaptations to this unusual environment.
Antioxidant Characteristics and Identification of Peptides from Sorghum Kafirin Hydrolysates
Authors: Xu Shiwei , Shen Yanting , Chen Gengjun , Bean Scott , Li Yonghui 
Published: July 2019

AbstractGrain sorghum is gaining interest for various uses as a highly sustainable crop. Kafirin is the main storage protein in grain sorghum. However, the antioxidant activities of kafirin hydrolysates have not been systematically investigated. The objectives of this study were to characterize the antioxidative hydrolysates and their ultrafiltrated fractions from sorghum kafirin using chemical assays and model systems and to identify the representative peptides. Kafirin Neutrase hydrolysates displayed promising yield and antioxidant capacity among those prepared with several different proteases. The effects of critical variables including protein substrate content, enzyme‐to‐substrate ratio, and reaction time on antioxidant production were studied. Selected hydrolysates were further fractionated through ultrafiltration and gel filtration chromatography (GFC). Medium‐sized fraction (3 to 10 kDa) revealed relatively higher total phenolic content and stronger antioxidative activities with regard to free radical scavenging activity, metal ion chelating activity, reducing power, and oxygen radical absorbance capacity. In an oil‐in‐water emulsion system, incorporation of selected fraction of hydrolysates inhibited the formation of primary and secondary oxidation products by 83.03% and 65.59%, respectively, by the end of a 14‐day incubation period. Similar oxidation inhibition effect was also observed in a ground meat system. Peptide compositions of the most promising fraction from GFC and reversed‐phase high‐performance liquid chromatography were identified using matrix‐assisted laser desorption ionization–time of flight/time of flight mass spectrometry.Practical ApplicationThis study provided a feasible approach to produce peptide antioxidants from sorghum kafirin. The novel naturally derived antioxidants could be potentially used as alternatives or synergetic components to synthetic antioxidants in improving the oxidative stability of various food products.
Schizophrenia is associated with increased risk of subsequent substance abuse diagnosis: A nation‐wide population‐based register study
Authors: Petersen Stine Mai , Toftdahl Nanna Gilliam , Nordentoft Merete , Hjorthøj Carsten 
Published: July 2019

AbstractAimsWe aimed to investigate whether or not a diagnosis of schizophrenia increases the risk of a substance abuse diagnosis.DesignProspective cohort study using a longitudinal study design.Setting and participantsIndividuals born in Denmark from 1955 to 1999 and registered in the Danish registers between 1 January 1968 and 1 July 2013.MeasurementsWe investigated the associations between schizophrenia and ICD diagnoses of substance abuse, both established through various Danish registers. The Cox regression model was used and adjusted for calendar year, gender, urbanicity, co‐abuse, other psychiatric diagnoses, parents' substance abuse and psychiatric history, parents' immigration and parents' socio‐economic position. Individuals diagnosed with substance abuse less than a year after diagnosis of schizophrenia were classified as not diagnosed with schizophrenia.FindingsThe cohort consisted of 3 133 968 individuals. During follow‐up (103 212 328 person‐years at risk), a total of 14 007 individuals developed schizophrenia, with 2885 subsequently diagnosed with substance abuse. A diagnosis of schizophrenia was positively associated with the risk of developing substance abuse [hazard ratio (HR) = 3.69, 95% confidence interval (CI) = 3.56–3.83]. Additionally, adjusting for a co‐abuse markedly affected the associations, making schizophrenia primarily associated with an increased risk of abuse of cannabis, alcohol, stimulants and other substances (adjusted HR = 2.48, 95% CI = 2.34–2.64 for cannabis; HR = 1.94, 95% CI = 1.87–2.02 for alcohol; HR = 1.77, 95% CI = 1.61–1.95 for stimulants; HR = 1.36, 95% CI = 1.20–1.54 for other substances). The association was still significant 10–15 years subsequent a diagnosis of schizophrenia (HR = 2.50, 95% CI = 2.26–2.76).ConclusionsIn Denmark a diagnosis of schizophrenia is significantly associated with increased risk of subsequent diagnosis of substance abuse.
Population‐based case‐control study: chemoprotection of colorectal cancer with non‐aspirin nonsteroidal anti‐inflammatory drugs and other drugs for pain control
Authors: Rodríguez‐Miguel Antonio , García‐Rodríguez Luis A. , Gil Miguel , Barreira‐Hernández Diana , Rodríguez‐Martín Sara , de Abajo Francisco J. 
Published: July 2019

SummaryBackgroundInflammation and overexpression of cyclooxygenase‐2 (COX‐2) have been described to play a key role in the progression from nonpathologic intestinal mucosa to colorectal cancer (CRC).AimsTo assess the chemoprotective effect of non‐aspirin nonsteroidal anti‐inflammatory drugs (NA‐NSAIDs) under different patterns of use in a Mediterranean population and to explore the potential effect of symptomatic slow‐acting drugs for osteoarthritis (SYSADOAs; chondroitin sulfate and glucosamine) and metamizole (or dipyrone), also reported to influence COX‐2 activity.MethodsWe performed a case‐control study nested in a cohort extracted from the primary care database, BIFAP. From 2001 to 2014, we included 15 491 incident cases and 60 000 random controls. To estimate the association between the drugs of interest and CRC, we built logistic regression models to compute the adjusted‐odds ratios (AOR) and 95% confidence intervals (CI).ResultsNA‐NSAIDs use was associated with a reduced risk of CRC (AOR = 0.67; 95% CI: 0.63‐0.71) and increased linearly with duration of treatment (p for trend <0.001). The effect diminished upon discontinuation but persisted statistically significant up to 1 year. All individual NA‐NSAIDs examined showed a decreased risk. The concomitant use of proton‐pump inhibitors (PPI) had no impact on the protective effect of NA‐NSAIDs; AORPPI + NSAID = 0.64; 0.58‐0.71. SYSADOA use was associated with a reduced risk (0.79; 0.69‐0.90) but disappeared after the exclusion of NSAID users during the previous 1 or 3 years (0.85; 0.70‐1.04 and 1.00; 0.76‐1.31 respectively). Metamizole did not show a chemoprotective effect.ConclusionsNA‐NSAID use is associated with a duration‐dependent risk reduction of CRC not shared by SYSADOAs or metamizole.
Single‐port robot‐assisted laparoscopic radical prostatectomy: initial experience and technique with the da Vinci®SP platform
Authors: Dobbs Ryan W. , Halgrimson Whitney R. , Madueke Ikenna , Vigneswaran Hari T. , Wilson Jessica O. , Crivellaro Simone 
Published: July 2019

ObjectivesTo assess the safety and feasibility of the da Vinci® SP (Intuitive Surgical, Sunnyvale, CA, USA) robotic platform for a consecutive series of patients who underwent single‐port robot‐assisted laparoscopic radical prostatectomy (SP‐RALP).Patients and MethodsIn all, 10 consecutive patients with biopsy confirmed prostate cancer underwent SP‐RALP at our institution. Pre‐, peri‐, and postoperative data were prospectively collected for key outcomes including: estimated blood loss (EBL), operative time, postoperative pain requirements, duration of hospital stay, and complications.ResultsThe patients were aged 52–77 years with a body mass index of 24.4–36.7 kg/m2. Prostate volumes ranged from 26 to 136 mL, with a mean (sd) PSA (prostate specific antigen) level of 11.0 (10.6) ng/mL. Lymph node dissection was performed in four patients and nerve sparing in five. No intraoperative complications occurred, and no patients required conversion to an open approach. Total EBL was 20–150 mL, with a median (interquartile range [IQR]) console time of 189 (171–207) min and operative time of 234 (216–247) min. No patients were readmitted or required intervention. Urethral catheters were removed at a median (IQR) of 10 (8–11) days after surgery.ConclusionSP‐RALP appears to be a safe and feasible approach to performing robotic radical prostatectomy. Long‐term follow‐up will be necessary to assess initial oncological and functional results.
Shallow‐water deltaic clinoforms and process regime
Authors: Plink‐Björklund Piret 
Published: July 2019

AbstractUtilizing two outcrop data sets with dip direction exposures of shallow‐water (tens of meters) deltaic clinoforms, this paper quantifies sedimentary facies proportions and clinoform lengths and gradients, and links process regimes to delta clinoform dimensions. Both data sets are from foreland basins, the Cretaceous Chimney Rock Sandstone of the Rock Springs Formation from the US Western Interior, and the Eocene Brogniartfjellet Clinoform Complex 8 of the Battfjellet Formation from the Central Basin of Spitsbergen. Sedimentary facies indicate presence of both river‐ and wave‐dominated clinothems in each data set. Facies characteristics and distribution implies that river‐dominated clinothem progradation was primarily driven by deposition from weak hyperpycnal flow turbidity currents across the clinoforms, and minor slumps. Wave‐dominated clinothems were constructed by wave processes rather than alongshore currents, and are also progradational subaerial clinoforms, with one exception, where the formation of a compound subaqueous clinoform set indicates erosion and sediment bypass above the wave base. Sediment distribution and lithological heterogeneity in the river‐dominated clinothems is controlled by individual hyperpycnal flow events or mouth‐bar collapse events, and thus by self‐organization and minimal reworking that results in a heterogeneity that is difficult to predict (high entropy). The efficient reworking of river‐derived sediments in wave‐dominated clinothems results in predictable lithological sediment partitioning (low entropy). Clinoform dimension analyses show that although of similar sediment caliber, river‐dominated clinoforms in both data sets are on average 3–4 times steeper and 3–4 times shorter than the wave‐dominated clinoforms, with mean gradients of ca 4 degrees and ca 1 degree, respectively, and mean lengths of 150–230 m and 640–760 m. These results require corroboration from additional data sets, but do suggest that river‐ and wave‐dominated delta clinoforms are likely to have distinct downdip extents (lengths) and gradients for given clinoform heights. Clinoform shape can thus be a method for differentiating ancient river‐ vs. wave‐dominated deltaic clinoforms, in addition to their sedimentary facies, biogenic features and sandstone maturity, and helpful when incorporated into reservoir models.
Similar effectiveness of R‐CHOP‐14 and ‐21 in diffuse large B‐cell lymphoma—data from the prospective German Tumour Registry Lymphatic Neoplasms
Authors: Knauf Wolfgang , Abenhardt Wolfgang , Mohm Johannes , Rauh Jacqueline , Harde Johanna , Kaiser‐Osterhues Anja , Jänicke Martina , Marschner Norbert ,   the TLN‐Group (Tumour Registry Lymphatic Neoplasms)
Published: July 2019

AbstractObjectivesR‐CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine, prednisone) is the standard therapy for patients with previously untreated diffuse large B‐cell lymphomas (DLBCL). Dose‐dense two‐weekly ‘R‐CHOP‐14’ was not superior over three‐weekly ‘R‐CHOP‐21’ in randomised clinical trials (RCTs). We present real‐world data on effectiveness of R‐CHOP‐14 and R‐CHOP‐21 in patients with DLBCL treated in German routine practice.MethodsWe identified 582 patients with DLBCL treated with R‐CHOP‐14 or R‐CHOP‐21 in 92 sites from the prospective clinical cohort study Tumour Registry Lymphatic Neoplasms. Patients’ schedules were classified by (a) length of the initial first cycle and (b) length of cycles 1‐4.ResultsAbout 55% of patients received R‐CHOP‐21, 45% R‐CHOP‐14, in median 6 cycles. 51% and 55% of patients, respectively, were able to continue their initial R‐CHOP‐14 and R‐CHOP‐21 schedule. While most characteristics between the patient cohorts were similar, patients receiving R‐CHOP‐21 presented slightly more often with tumour stage I and lower IPI risk. 3‐year overall survival of patients with R‐CHOP‐14 and R‐CHOP‐21 did not differ: 84% vs 84% (first cycle), 87% vs 89% (cycles 1‐4).ConclusionsPatients with DLBCL in Germany are slightly more likely to receive R‐CHOP‐21 than R‐CHOP‐14. Both schedules are similarly effective in routine practice confirming the results from RCTs.
Soil type and land use effects on tensorial properties of saturated hydraulic conductivity in northern Germany
Authors: Horn Rainer , Mordhorst Anneka , Fleige Heiner , Zimmermann Iris , Burbaum Bernd , Filipinski Marek , Cordsen Eckhard 
Published: July 2019

AbstractLong‐term soil management can produce anisotropic impacts on soil structure, resulting in differences in horizontal and vertical hydraulic conductivity. As limited data exist on these impacts, this study provides a broad‐scale assessment across 764 soil profiles under arable and grassland use in northern Germany (Federal State: Schleswig‐Holstein). The soils were sampled in the four geological regions: Weichselian glacial region, the sandy outwash region (Lower “Geest”), the Saalian glacial region (Higher “Geest”) and the marshland with alluvial deposits. Saturated hydraulic conductivity (Ks, either in a horizontal (Ks_h) or vertical direction (Ks_v)) and the pore‐size distribution were determined on undisturbed soil samples (100 cm3), whereas the grain size distribution was analysed on disturbed samples from the major soil horizons. This research work presents Ks_h and Ks_v values for representative soil types of the four geological regions down to a depth of 60 cm. Irrespective of the parent material in the four geological regions, arable soils showed a pronounced anisotropy of Ks in the horizontal direction. However, Ks_h and Ks_v also showed a high variability across the geological regions from approximately 1 to 800 cm d−1, whereas the ratio of Ks_h to Ks_v ranged from 0.1 to 500. In the marshland (dominated by Gleysols), the direction‐dependent values were superimposed by sedimentation processes of the marine material and/or structural development processes such as vertical shrinkage or bioturbation processes. Under grassland, the topsoils primarily indicated horizontally anisotropic flow conditions. In the “Geest” area with a high share of dairy farming, both top‐ and subsoils displayed the highest horizontal anisotropy values, indicating the stress‐induced formation of a platy structure caused by trampling, grass harvesting or slurry application with heavy machinery. Soil type (e.g., Stagnic Luvisols, Stagnosols or Anthrosols) and horizon‐dependent horizontal anisotropy were also more pronounced in arable than in grassland subsoils.Highlights
Hydraulic conductivity in arable subsoils shows mostly horizontal behaviour.
Hydraulic conductivity in grassland topsoils shows mostly horizontal behaviour.
The anisotropic degree and its direction depend on land use type and clay content of the soils.
Structural and biochemical consequences of pyridoxine‐dependent epilepsy mutations that target the aldehyde binding site of aldehyde dehydrogenase ALDH7A1
Authors: Laciak Adrian R. , Korasick David A. , Wyatt Jesse W. , Gates Kent S. , Tanner John J. 
Published: July 2019

In humans, certain mutations in the gene encoding aldehyde dehydrogenase 7A1 are associated with pyridoxine‐dependent epilepsy (PDE). Understanding the impact of PDE‐causing mutations on the structure and activity of ALDH7A1 could allow for the prediction of symptom‐severity and aid the development of patient‐specific medical treatments. Herein, we investigate the biochemical and structural consequences of PDE missense mutations targeting residues in the aldehyde substrate binding site: N167S, P169S, A171V, G174V, and W175G. All but G174V could be purified for biochemical and X‐ray crystallographic analysis. W175G has a relatively mild kinetic defect, exhibiting a fivefold decrease in kcat with no change in Km. P169S and N167S have moderate defects, characterized by catalytic efficiencies of 20‐ and 100‐times lower than wild‐type, respectively. A171V has a profound functional defect, with catalytic efficiency 2000‐times lower than wild‐type. The crystal structures of the variants are the first for any PDE‐associated mutant of ALDH7A1. The structures show that missense mutations that decrease the steric bulk of the side chain tend to create a cavity in the active site. The protein responds by relaxing into the vacant space, and this structural perturbation appears to cause misalignment of the aldehyde substrate in W175G and N167S. The P169S structure is nearly identical to that of the wild‐type enzyme; however, analysis of B‐factors suggests the catalytic defect may result from altered protein dynamics. The A171V structure suggests that the potential for steric clash with Val171 prevents Glu121 from ion pairing with the amino group of the aldehyde substrate.EnzymesAldehyde dehydrogenase 7A1 (EC1.2.1.31).DatabasesCoordinates have been deposited in the Protein Data Bank under the following accession codes: 6O4B, 6O4C, 6O4D, 6O4E, 6O4F, 6O4G, 6O4H.