bluuebunny/crossref_metadata_2025_split huggingface dataset:
LHPP suppresses bladder cancer cell proliferation and growth via inactivating AKT/p65 signaling pathway
Authors: Li Yansheng , Zhang Xin , Zhou Xiaoguang , Zhang Xiaodong 
Published: July 2019

Abstract
Bladder cancer (BC) is one of the commonest malignancies in the urinary system. Recent evidences have shown that Phospholysine phosphohistidine inorganic pyrophosphate phosphatase (LHPP) serves as a tumor suppressor in hepatocellular carcinoma and cervical cancer. However, little is known about its function in BC. Here, we aimed to investigate the role of LHPP in BC. We found that LHPP was down-regulated in BC tissues and cells. Knockdown of LHPP promoted the proliferation and growth of BC cells T24 and 5637. Inverse results were observed in SW780 and BIU87 cells with ectopic LHPP expression. LHPP also repressed the glycolysis of BC cells. At the molecular level, LHPP silencing led to enhanced phosphorylation of both AKT and p65, as well as up-regulation of their downstream targets Bcl-2 and Cyclin D1. Inhibition of AKT by MK2206 blunted the increased phosphorylation of p65 caused by LHPP knockdown, suggesting that LHPP silencing activated p65 through AKT. Importantly, p65 inhibitor (caffeic acid phenethyl ester) exhibited larger suppressive effect on the proliferation of LHPP knockdown BC cells as compared with Ctrl cell. Our study demonstrates that LHPP suppresses BC cell growth via inactivating AKT/p65 signaling pathway.
Progesterone receptor antagonist provides palliative effects for uterine leiomyoma through a Bcl-2/Beclin1-dependent mechanism
Authors: Zhang Lindong , Feng Quanling , Wang Zhiting , Liu Pingping , Cui Shihong 
Published: July 2019

Abstract
Uterine leiomyoma is the most common benign smooth muscle tumor of uterus in women of reproductive age, with a high lifetime incidence. Nowadays, the exploration on the pharmacotherapies, such as progesterone receptor antagonist (PRA) requires more attention. Hence, the current study aimed to examine whether mifepristone, a PRA, influences the autophagy and apoptosis of uterine leiomyoma cells. Primary uterine leiomyoma cells were collected from 36 patients diagnosed with uterine leiomyoma to establish PR-M-positive (PR-M[+]) cells. The lentiviral vector overexpressing or silencing PR-M was subsequently delivered into one part of PR-M(+) cells in order to evaluate the role of PR-M in PR-M(+) cells. The results obtained revealed that cell viability was increased, while cell autophagy and apoptosis were diminished in the PR-M(+) cells treated with overexpressed PR-M, whereby the Bcl-2 level was elevated and the level of Beclin1 was reduced. An opposite trends were identified following treatment with knockdown of PR-M. Mifepristone at different concentrations (low, moderate, or high) was then applied to treat another part of the PR-M(+) cells. Mifepristone was identified to promote cell autophagy and apoptosis, decrease Bcl-2 level and increase Beclin1 level, accompanied by weakened interaction between Bcl-2 and Beclin1. Moreover, these effects of mifepristone on PR-M(+) cells were enhanced with increasing of the concentration. Taken together, the present study present evidence indicates the ability of PRA to regulate the Bcl-2/Beclin1 axis, ultimately promoting the autophagy and apoptosis of uterine leiomyoma cells, highlighting that PRA serves as a promising therapeutic target for the treatment of uterine leiomyoma.
A New Method for Studying Statistical Learning in Young Children
Authors: Kavakci Mariam , Dollaghan Christine 
Published: June 2019

Purpose
The purpose of this study was to determine whether a new oculomotor serial reaction time (RT) task revealed statistical sequence learning in young children.

Method
We used eye tracking to measure typically developing children's oculomotor RTs in response to cartoon-like creatures that appeared successively in quadrants of a monitor during 200 trials: an initial patterned phase (120 trials) in which the creature's location reflected 15 repetitions of an 8-element sequence, a pseudorandom phase (40 trials) in which the location was not predictable, and a final patterned phase (40 trials). In an auditory–visual version of the task, spoken nonwords linked to quadrants preceded the creature's appearance. In Study 1, we administered either the visual or the auditory–visual version to 5- and 6-year-old children; in Study 2, we examined the performance of 4-year-olds on the auditory–visual version.

Results

In both studies, group mean RT
z
scores were significantly shorter (
p
< .05) during patterned than pseudorandom phases, with large effect sizes (Cohen's
dz
values = 1.17–1.79).

Conclusion
The new oculomotor serial RT task detected statistical sequence learning in typically developing children.
Ratunku!
or Just
Tunku!
Evidence for the Reliability and Concurrent Validity of the Language Use Inventory–Polish
Authors: Białecka-Pikul Marta , Filip Anna , Stępień-Nycz Małgorzata , Kuś Katarzyna , O'Neill Daniela K. 
Published: July 2019

Purpose

To date, there is no tool for assessing early pragmatic development of Polish-speaking children. This study aimed to adapt to Polish a standardized parent report measure, the Language Use Inventory (LUI;
O'Neill, 2009
, in order to enable cross-cultural comparisons and to use the LUI-Polish to screen for pragmatic development in children 18–47 months of age. We concentrated on the sociocultural and functional adaptation of LUI and aimed to demonstrate its reliability, developmental sensitivity, and concurrent validity.

Method
Parents completed an online version of LUI-Polish, longitudinally at 3 time points (when the child was 20, 32, and 44 months old). In addition, parents completed the Polish adaptations of the Questionnaire for Communication and Early Language at 22 months and the Language Development Survey at 24 months. Children's spontaneous speech was assessed at 24 months, and their expressive and receptive vocabulary was assessed at 36 months.

Results
All 3 parts of the LUI-Polish (Gestures, Words, and Sentences) showed very good levels of internal consistency at each time point. Significant correlations were observed between all parts of the LUI-Polish at all 3 measurement time points. The expected developmental trajectory was observed for boys and girls providing evidence of its developmental sensitivity for children between the ages of 2 and 4 years: an increase with age in the total score (due to an increase in Words and Sentences) and a decrease in Gestures. Supporting concurrent validity, significant correlations were found between children's performance on (a) the LUI-Polish at 20 months and the Questionnaire for Communication and Early Language at 22 months as well as the Language Development Survey and spontaneous speech measures at 24 months and (b) the LUI-Polish at 32 months and the 2 measures of vocabulary comprehension and production at 36 months.

Conclusion
The Polish adaptation of the LUI demonstrated good psychometric properties that provide a sound basis for cross-cultural comparisons and further research toward norming of the LUI-Polish. Moreover, the expected developmental trajectory in the pragmatic development of Polish children was observed.
Kontinuierliches Glukosemonitoring (CGM)
Authors: Kolassa Ralf , Thomas Andreas , Siegmund Thorsten 
Published: June 2019

ZUSAMMENFASSUNGCGM liefert nicht nur Glukosekurven, die einerseits dynamische Glukoseregulation und andererseits die Komplexität des Glukosestoffwechsels zeigen, sie stellen auch Anforderungen an deren Interpretation. Dazu ist ein strukturiertes Vorgehen unabdingbar, nämlich erstens die Betrachtung der Datenqualität (richtige Kalibrierung, wenn nötig, wenige Datenlücken), zweitens die Beurteilung, ob die Kurven stark von Hypoglykämien beeinflusst sind und erst dann drittens die Beurteilung von Glukoseniveau, Glukosestabilität und Glukosemustern. Unbedingt zu beachten ist, dass die CGM-Kurven die Glukoseregulation und das Therapiemanagement der Patienten beinhalten. Unter der Sensorunterstützten Pumpentherapie (SuP) mit Systemen mit Hypoglykämieabschaltung kommt hinzu, dass bei Eingriff des Glukosesensors in die Insulinabgabe die CGM-Kurve vom Systemmanagement modifiziert wird. Auf die Herausforderungen und die Möglichkeiten der CGM-Kurveninterpretation wird nachfolgend eingegangen.
Die monetären Aspekte der Blutzuckerselbstkontrolle
Authors: Burchert Heiko , Engelmann Julius , Kannenberg Maria 
Published: June 2019

ZusammenfassungDass Blutzuckerteststreifen und Sensoren mit Geld und Kosten verbunden sind, bedarf grundsätzlich keiner Erwähnung. Die gesetzlichen Krankenversicherungen zahlten allein 2017 für die verordneten Blutzuckerteststreifen 700 Mio. Euro 1. Die Sensoren kosten die gesetzlichen Krankenversicherungen schätzungsweise 234 Mio. Euro pro Jahr. Jede einzelne der in diesem Zusammenhang ausgestellten Verordnungen (ca. 0,1 Mio.) sowie der Arbeitsaufwand der damit ver-bundenen Untersuchungen und Beratungen des Diabetikers gehen zu Lasten der Budgets der verordnenden Ärzte. Zusammengefasst können die Höhe und die Entwicklung der Kosten für die Versorgung und Betreuung von Diabetikern in Deutschland in den KoDiM-Studien 2, 3, 4 nachgelesen werden. Noch nicht berücksichtigt ist bisher die Sichtweise von „einigen“ Diabetikern. Die durch eine Verordnung erhaltenen Blutzuckerteststreifen oder Sensoren nutzen sie entgegen den Absprachen mit dem betreuenden Arzt nicht für ihr Therapie-Selbstmanagement. Vielmehr wird mit diesen Produkten durch deren Verkauf, zum Beispiel auf eBay oder anderen Online-Handelsportalen ein zum Teil beträchtliches Nebeneinkommen realisiert. Welche Dimensionen dies zwischenzeitlich erreicht hat, wer Verkäufer und Käufer sind und welche Konsequenzen sich möglicherweise für die verordnenden Ärzte ergeben, ist Gegenstand der folgenden Ausführungen.
Cholangioscopy-guided lithotripsy for difficult bile duct stone clearance in a single session of ERCP: results from a large multinational registry demonstrate high success rates
Authors: Maydeo Amit P. , Rerknimitr Rungsun , Lau James Y. , Aljebreen Abdulrahman , Niaz Saad K. , Itoi Takao , Ang Tiing Leong , Reichenberger Jörg , Seo Dong Wan , Ramchandani Mohan K. , Devereaux Benedict M. , Lee Jong Kyun , Goenka Mahesh K. , Sud Randhir , Nguyen Nam Q. , Kochhar Rakesh , Peetermans Joyce , Goswamy Pooja G. , Rousseau Matthew , Bhandari Surya Prakash , Angsuwatcharakon Phonthep , Tang Raymond S. Y. , Teoh Anthony Y. B. , Almadi Majid , Lee Yun Nah , Moon Jong Ho ,   the SpyGlass AMEA Registry Group
Published: June 2019

Abstract
Background Peroral cholangioscopy (POCS) can be useful for difficult bile duct stone clearance. Large prospective multinational data on POCS-guided lithotripsy for clearing difficult bile duct stones in a single session of endoscopic retrograde cholangiopancreatography (ERCP) are missing.
Methods Patients with difficult bile duct stones (defined as one or more of: largest stone diameter ≥ 15 mm, failed prior attempt at stone clearance, impacted, multiple, hepatic duct location, or located above a stricture) were enrolled at 17 centers in 10 countries. The principal endpoint was stone clearance in a single ERCP procedure using POCS.
Results 156 patients underwent 174 sessions of POCS-guided electrohydraulic or laser lithotripsy. Stone clearance had failed in a previous ERCP using traditional techniques in 124/156 patients (80 %), while 32 /156 patients (21 %) were referred directly to POCS-guided therapy based on preprocedural assessment of the difficulty of stone clearance. In 101/156 patients (65 %), there were impacted stones. POCS-guided stone clearance was achieved in a single POCS procedure in 125 /156 patients (80 %, 95 % confidence interval [CI] 73 % – 86 %), and was significantly more likely for stones ≤ 30 mm compared with > 30 mm (odds ratio 7.9, 95 %CI 2.4 – 26.2; P = 0.002). Serious adverse events occurred in 3/156 patients (1.9 %, 95 %CI 0.4 % – 5.5 %), and included pancreatitis, perforation due to laser lithotripsy, and cholangitis (n = 1 each), all resolved within 1 week.
Conclusion POCS-guided lithotripsy is highly effective for clearance of difficult bile duct stones in a single procedure and successfully salvages most prior treatment failures. It may also be considered first-line therapy for patients with difficult choledocholithiasis to avoid serial procedures.
Thyroid Lymphoepithelial Cysts Mimicking Calcified or Solid Nodules on Ultrasonography
Authors: Tsutsuura Yukie , Hirokawa Mitsuyoshi , Suzuki Ayana , Ota Hisashi , Oshita Maki , Fukushima Mitsuhiro , Kobayashi Kaoru , Miyauchi Akira 
Published: July 2019

AbstractThyroid lymphoepithelial cysts (TLECs) are rare, and detailed ultrasonography (US) findings have not been reported. This study aimed to examine in detail the US findings for 32 TLECs and to clarify the diagnostic problems associated with them.We examined 32 TLECs resected from 21 patients at the Kuma hospital between January 2008 and April 2018. All patients underwent US before resection. From the patients’ medical records, we retrospectively assessed US reports and photographs of TLECs.The following four types of TLECs were classified: cystic, mixed solid and cystic, pseudo-solid, and pseudo-calcified types. The incidences were 50.0%, 12.5%, 12.5%, and 25.0%, respectively. Among the four types, pseudo-calcified TLECs were the smallest in size (mean: 7.1 mm). Of 24 nodules that had been interpreted in US reports, 11, 9, 1, 2, and 1 were benign, very low, low, intermediate, and high, respectively. Calcification and intramural solid growth were not identified by histological examination.We should be aware that approximately half of TLECs do not exhibit US appearances typical of simple cysts, and TLECs may mimic calcified or solid nodules on US, although the reason remains unknown.
Determination of Freeway Space in Completely Edentulous Patients Using Lateral Profile Photographs—In Vivo Study
Authors: Dagdiya Monika , Pakhan Ashok , Dubey Surekha , Sathe Seema , Dagdiya Manish 
Published: June 2019

Abstract
Objective This study aims to determine the freeway space (FWS) using lateral profile photograph (LPP) as an adjunct in completely edentulous patients.
Materials and Methods In this study, 30 patients in the age group of 45 to 60 years who met with the criteria were included. LPPs were taken for all participants using standard protocol and a duplicate copy was obtained, on which three soft tissue reference points—porion (Stp), gnathion (Stgn), and gonion (Stg)—were marked and joined to form an angle Stp-Stg-Stgn. This angle was correlated with the mean FWS obtained using swallowing. Simple linear regression model was used to develop a prediction formula for FWS using Stp-Stg-Stgn angle as the independent variable.
Result This study shows that the angle Stp-Stg-Stgn had a significant negative correlation with FWS.
Correlation of Optical Coherence Tomographic Findings with Clinical Features in High Myopia
Authors: Rao Evangeline , Mishra Maithili , Kerkar Sheela , Ahuja Arjun 
Published: June 2019

AbstractThis is a cross-sectional observational study to correlate relationship between macular and retinal nerve fiber layer (RNFL) thickness in relation to clinical features in high myopia. A total of 100 eyes of 50 consecutive patients underwent optical coherence tomography (OCT) of the macula and RNFL. It was observed that correlation of RNFL thickness to the axial length is better than that of RNFL thickness to the spherical equivalent. The macular thickness in the parafoveal region was observed to be thicker than the perifoveal region in all quadrants. This study therefore emphasizes the need to have macular thickness nomogram for high myopes to avoid misinterpretation of OCT results due to axial length and refractive error and, also, the need for a routine baseline OCT scan for all high myopia patients.
Effect on Insulin upon Storage in Extreme Climatic Conditions (Temperature and Pressure) and Their Preventive Measures
Authors: Khurana Girish , Gupta Vipul 
Published: June 2019

AbstractInsulin is a naturally occurring hormone secreted by the pancreas. Insulin is required by the body cellsto remove and use glucose from the blood. The insulin and its various analogues are essential in management of type 1 diabetes mellitus. This study has been done to analyze how variation in various storage conditions and climatic changes causes change in therapeutic efficacy. Storage condition affects the stability of insulin as observed in a study in which insulin stored at temperature between 32 and 37°C showed 14 to 18% decrease in its potency and could not cause a significant decrease in blood sugar level when compared with those receiving insulin stored at 5°C. This work was done with the aim of finding the effect of climatic changes and storage condition on efficacy of insulin.
Clinical Profile and Management Techniques of Surgical Obstructive Jaundice Cases in a Tertiary Center at Bareilly
Authors: Singh Shailendra Kumar , Choudhary Porus , Yadav Ruby 
Published: June 2019

Abstract
Introduction Obstructive jaundice is associated with high morbidity and mortality. Obstructive jaundice is not a definitive diagnosis. Detailed evaluation to establish the etiology of the cholestasis and cause of obstruction is crucial to avoid secondary pathologic changes and to plan different surgical techniques to intervene at an early stage.
Materials and Methods A cross-sectional study was conducted among 50 cases of surgical obstructive jaundice at Shri Ram Murti Smarak Institute of Medical Sciences (SRMSIMS), Bareilly.
Results The mean age of this study population was 48.44 ± 8.2 years, and 48% (24) patients had obstructive jaundice of benign etiology, whereas 52% (26) had malignant etiology. Among males, the common presentation was choledocholithiasis in benign disease and carcinoma of the gallbladder among malignancy. In females also, disease presentation was similar to that of males. Percutaneous transhepatic biliary drainage (PTBD) was the most common method of biliary decompression in malignant group. For biliary decompression in patients of benign etiology, common bile duct (CBD) exploration with T-tube drainage was done in most cases.
Conclusion Obstructive jaundice has different etiologic spectrum in both males and females. Irrespective of etiology, common presentation was pain (94% of the cases). Most patients with malignant etiology presented with palpable lump. PTBD was the most common method of biliary decompression in malignant group. CBD exploration with T-tube drainage has higher values of decrease in serum bilirubin, serum bilirubin (indirect), serum alkaline phosphatase, and albumin.
The Percutaneous Endoscopic Lumbar Interbody Fusion (PELIF): An Advanced and Innovation Technique
Authors: de Alcantara Tabata , Nogueira Monica Paschoal , Silva Anibal Correia 
Published: June 2019

AbstractThe degenerative spine changes, and its costs, have increased with high rates of work absenteeism and difficult clinical management. The search for minimally invasive treatments, with better results and early patients recover, with rapid hospital discharge are alternatives for these problems. The percutaneous endoscopic lumbar interbody fusion (PELIF) is a new and advanced option.
Isolation and identification of N6-isopentenyladenosine as the cytotoxic constituent of a marine sponge Oceanapia sp.
Authors: Nakamukai Shohei , Ise Yuji , Ohtsuka Susumu , Okada Shigeru , Matsunaga Shigeki 
Published: June 2019

ABSTRACT
N 6-Isopentenyladenosine (i6A) was isolated from a marine sponge Oceanapia sp. as the major cytotoxic constituent along with N6-isopentenyladenosine 5ʹ-monophosphate (i6AP) which was inactive. The structures of i6A and i6AP were assigned by a combination of the analysis of NMR spectroscopy and mass spectrometry. This is the first isolation of i6A and i6AP from a marine sponge.
Building Praise: Augustan Rome and Epideictic
Authors: Lamp Kathleen S. 
Published: July 2019

ABSTRACTIn this essay, I examine two epideictic artifacts from the Roman Principate, The Res Gestae Divi Augusti and the summi viri, arguing Augustus used them to reshape the model of a good leader, in part, by emphasizing contributing to the built environment of the city. Additionally, the public and visual nature of these artifacts made them highly accessible to those outside of the Roman elite, who may have sought social mobility through the imperial bureaucracy allowing for more diverse participation in the Roman government. I close by considering the influence of classical exemplars on U.S. civic spaces.
Identity and Difference in Aelius Aristides’ “Regarding Sarapis”
Authors: Atwill Janet M. , Portz Josie 
Published: July 2019

ABSTRACTThis article posits that bringing diversity to histories of rhetoric may require not only revising canons but also “unwriting” the narratives of Western civilization in which canonical figures have been cast. Two conventions of these narratives are of special significance: fixed identities and narrative coherence. Focusing on the cultural contexts of Aelius Aristides’ “Regarding Sarapis,” we suggest that these conventions obscure the cultural differences that were always there.
Guaranteed global optimization of thin-film optical systems
Authors: Azunre Paul , Jean Joel , Rotschild Carmel , Bulovic Vladimir , Johnson Steven G , Baldo Marc A 
Published: July 2019

Abstract
A parallel deterministic global optimization algorithm for thin-film multilayer optical coatings is developed. This algorithm enables locating a global solution to an optimization problem in this class to within a user-specified tolerance. More specifically, the algorithm is a parallel branch-and-bound method with applicable bounds on the merit function computed using Taylor models. This study is the first one, to the best of our knowledge, to attempt guaranteed global optimization of this important class of problems, thereby providing an overview and an assessment of the current state of such techniques in this domain. As a proof of concept on a small scale, the method is illustrated numerically and experimentally in the context of antireflection coatings for silicon solar cells—we design and fabricate a three-layer dielectric stack on silicon that exhibits an average reflectance of (2.53 ± 0.10)%, weighted over a broad range of incident angles and the solar spectrum. The practicality of our approach is assessed by comparing its computational cost relative to traditional stochastic global optimization techniques which provide no guarantees on their solutions. While our method is observed to be significantly more computationally expensive, we demonstrate via our proof of concept that it is already feasible to optimize sufficiently simple practical problems at a reasonable cost, given the current accessibility of cloud computing resources. Ongoing advances in distributed computing are likely to bring more design problems within the reach of deterministic global optimization methods, yielding rigorous guaranteed solutions in the presence of practical manufacturing constraints.