bluuebunny/crossref_metadata_2025_split huggingface dataset:
Corticostriatal synaptic weight evolution in a two-alternative forced choice task
Authors: Vich C. , Dunovan K. , Verstynen T. , Rubin J. 
Published: February 2019

AbstractIn natural environments, mammals can efficiently select actions based on noisy sensory signals and quickly adapt to unexpected outcomes to better exploit opportunities that arise in the future. Such feedback-based changes in behavior rely on long term plasticity within cortico-basal-ganglia-thalamic networks, driven by dopaminergic modulation of cortical inputs to the direct and indirect pathway neurons of the striatum. While the firing rates of corticostriatal neurons have been shown to adapt across a range of feedback conditions, it remains difficult to directly assess the corticostriatal synaptic weight changes that contribute to these adaptive firing rates. In this work, we simulate a computational model for the evolution of corticostriatal synaptic weights based on a spike timing-dependent plasticity rule driven by dopamine signaling that is induced by outcomes of actions in the context of a two-alternative forced choice task. Results show that plasticity predominantly impacts direct pathway weights, which evolve to drive action selection toward a more-rewarded action in settings with deterministic reward outcomes. After the model is tuned based on such fixed reward scenarios, its performance agrees with the results of behavioral experiments carried out with probabilistic reward paradigms.
Activated thiol Sepharose-based proteomic approach to globally quantify protein oxidation
Authors: Xu Yang , Neel Benjamin G 
Published: February 2019

AbstractReactive oxygen species (ROS) can act as second messengers for various signaling pathways, and abnormal oxidation contributes to multiple diseases, including cancer. Detecting and quantifying protein oxidation is crucial for a detailed understanding of redox signaling. We developed an Activated Thiol Sepharose (ATS)-based proteomic approach (ATSP) to globally quantify protein oxidation. ATSP can enrich for H2O2-sensitive thiol peptides, which are more likely to contain reactive cysteines involved in redox signaling. We applied our approach to analyze hereditary leiomyomatosis and renal cell carcinoma (HLRCC), a type of kidney cancer that harborsfumarate hydratase(FH)-inactivating mutations and has elevated ROS levels. Multiple proteins were oxidized in FH-deficient cells, including many metabolic proteins, such as the M2 isoform of pyruvate kinase (PKM2). Treatment of HLRCC cells with dimethyl fumarate (DMF) or PKM2 activators alter PKM2 oxidation levels. This newly developed redox proteomics method can globally detect oxidation of reactive cysteines and can be employed to analyze multiple physiological and pathological conditions.
Key aspects of neurovascular control mediated by specific populations of inhibitory cortical interneurons
Authors: Lee L , Boorman L , Glendenning E , Christmas C , Sharp P , Redgrave P , Shabir O , Bracci E , Berwick J , Howarth C 
Published: February 2019

AbstractInhibitory interneurons can evoke vasodilation and vasoconstriction, making them potential cellular drivers of neurovascular coupling. However, the specific regulatory roles played by particular interneuron subpopulations remain unclear. Our purpose was therefore to adopt a cell-specific optogenetic approach to investigate how somatostatin (SST) and neuronal nitric oxide synthase (NOS1)-expressing interneurons might influence neurovascular relationships. In mice, specific activation of SST- or NOS1-interneurons was sufficient to evoke haemodynamic changes similar to those evoked by physiological whisker stimulation. In the case of NOS1-interneurons, robust haemodynamic changes occurred with minimal changes in neural activity. Conversely, activation of SST-interneurons produced robust changes in evoked neural activity with shallow cortical excitation and pronounced deep layer cortical inhibition. This often resulted in a central increase in blood volume with corresponding surround decrease, analogous to the negative BOLD signal. These results demonstrate the role of specific populations of cortical interneurons in the active control of neurovascular function.
Altered brain function in anorexia nervosa and bulimia nervosa: A hierarchical series of task-based fMRI meta-analyses
Authors: Liu Bangshan , Liu Jin , Ju Yumeng , Wang Mi , Liu Tiebang , Zhang Yan , Li Lingjiang , Potenza Marc N. , Barron Daniel S. 
Published: February 2019

ABSTRACTBackgroundMany structural and functional magnetic resonance imaging (MRI) studies have reported differences in brain functional anatomy associated with eating disorders (EDs). We aimed to quantitatively synthesize the current literature of anorexia nervosa (AN) and bulimia nervosa (BN) with a goal of deriving a consensus across these studies.MethodsWe performed a hierarchical series of 49 activation likelihood estimation meta-analyses of 101 experiments from 63 studies at the disorder (AN+BN), diagnosis (AN or BN), and task (food-, body-, emotion- or cognitive function-related tasks) levels. We further performed sub-analyses at the diagnosis level to assess the influence of disease stage (current or recovered AN), subtype (restrictive AN, rAN), psychiatric comorbidity, medication, and data processing.ResultsWe did not observe consistent differences in brain activity across all hierarchies. Rather, we observed differences in brain activity in the right fusiform, left inferior parietal lobule and left precuneus that were primarily related to food (representing 19 experiments) and emotion (25 experiments) tasks performed by current AN patients (56 experiments).ConclusionsThe task-based functional MRI literature in AN and BN represents a heterogenous set of tasks and patients. Given this heterogeneity, we found very limited convergence across a rather large literature. Such limited convergence suggests individual task-based studies of EDs should be interpreted cautiously. We recommend that future studies of EDs carefully characterize patients based on nutritional status and that, beyond clinical diagnosis, studies utilize a trait- or cognitive-domain-based approach to define their populations of interest.Meta-ananlysis Registration“Meta-analysis of functional magnetic resonance imaging studies of eating disorders”, https://www.crd.york.ac.uk/prospero (Registration Number: CRD42018086497).
Aicardi-Goutières Syndrome gene Rnaseh2c is a metastasis susceptibility gene in breast cancer
Authors: Deasy Sarah K. , Uehara Ryo , Vodnala Suman K. , Yang Howard H. , Dass Randall A. , Hu Ying , Lee Maxwell P. , Crouch Robert J. , Hunter Kent W. 
Published: February 2019

AbstractBreast cancer is the second leading cause of cancer-related deaths in the United States, with the majority of these deaths due to metastatic lesions rather than the primary tumor. Thus, a better understanding of the etiology of metastatic disease is crucial for improving survival. Using a haplotype mapping strategy in mouse and shRNA-mediated gene knockdown, we identified Rnaseh2c, a scaffolding protein of the heterotrimeric RNase H2 endoribonuclease complex, as a novel metastasis susceptibility factor. We found that the role of Rnaseh2c in metastatic disease is independent of RNase H2 enzymatic activity, and immunophenotyping and RNA-sequencing analysis revealed engagement of the T cell-mediated adaptive immune response. Furthermore, the cGAS-Sting pathway was not activated in the metastatic cancer cells used in this study, suggesting that the mechanism of immune response in breast cancer is different from the mechanism proposed for Aicardi-Goutières Syndrome, a rare interferonopathy caused by RNase H2 mutation. These results suggest an important novel, non-enzymatic role for RNASEH2C during breast cancer progression and add Rnaseh2c to a panel of genes we have identified that together could determine patients with high risk for metastasis. These results also highlight a potential new target for combination with immunotherapies and may contribute to a better understanding of the etiology of Aicardi-Goutières Syndrome autoimmunity.Author SummaryThe majority of breast cancer-associated deaths are due to metastatic disease, the process where cancerous cells leave the primary tumor in the breast and spread to a new location in the body. To better understand the etiology of this process, we investigate the effects of gene expression changes in the primary tumor. In this study, we found that changing the expression of the gene Rnaseh2c changed the number of metastases that developed in the lungs of tumor-bearing mice. By investigating the enzyme complex Rnaseh2c is part of, RNase H2, we determined that Rnaseh2c’s effects may be independent of RNase H2 enzyme activity. Because Rnaseh2c is known to cause the autoimmune disease Aicardi-Goutières Syndrome (AGS), we tested whether the immune system is involved in the metastatic effect. Indeed, we found that the cytotoxic T cell response is important for mediating the effect that Rnaseh2c has on metastasis. Together these data indicate that Rnaseh2c expression contributes to a patient’s susceptibility to developing breast cancer metastasis and demonstrate that the immune system is involved in this outcome. The implications of this study suggest immunotherapy could be a viable treatment for breast cancer metastasis and may help inform the understanding of AGS and RNase H2 in cancer.
Age at death and comorbidity of dementia-related disorders among individuals with autism spectrum disorder
Authors: Barnard-Brak Lucy , Richman David , Yang Zhanxia 
Published: February 2019

PurposeAutism spectrum disorder (ASD) is a lifelong disorder that requires intervention and support services for a growing geriatric population. The purpose of this paper is to examine the mean age at death of individuals with ASD and subsequent comorbidity with Alzheimer’s disease, and any form of dementia, as a whole and according to sex.Design/methodology/approachData consisted of 1,754 individuals who had an ASD listed as one of the causes of deaths from the National Vital Statistics System with data from 1999 to 2015. In the current study, the authors present contradictory results with a mean age at death for individuals with ASD was 68 years by adjusting for changing prevalence rates.FindingsFemales with ASD had a higher mean age at death than males with ASD; consistent with the trend in the sex differences in the general population. The results of the current study also indicate that individuals with ASD were, in fact, less likely than the general population to have Alzheimer’s disease or a form of dementia. However, males with ASD were significantly more likely to have acquired Alzheimer’s disease or a form of dementia as compared to females with ASD.Originality/valueGuan and Li (2017) reported a mean age at death of 36 years old for individuals with ASD, which was subsequently reported in the mass media, most notably CNN. The authors contend that this study provides a more accurate estimate mean age at death.
Cloud privacy objectives a value based approach
Authors: Coss David Lewis , Dhillon Gurpreet 
Published: February 2019

Purpose
To effectively develop privacy policies and practices for cloud computing, organizations need to define a set of guiding privacy objectives that can be applied across their organization. It is argued that it is important to understand individuals’ privacy values with respect to cloud computing to define cloud privacy objectives.

Design/methodology/approach
For the purpose of this study, the authors adopted Keeney’s (1994) value-focused thinking approach to identify privacy objectives with respect to cloud computing.

Findings
The results of this study identified the following six fundamental cloud privacy objectives: to increase trust with cloud provider, to maximize identity management controls, to maximize responsibility of information stewardship, to maximize individual’s understanding of cloud service functionality, to maximize protection of rights to privacy, and to maintain the integrity of data.

Research limitations/implications
One limitation is generalizability of the cloud privacy objectives, and the second is research bias. As this study focused on cloud privacy, the authors felt that the research participants’ increased knowledge of technology usage, including that of cloud technology, was a benefit that outweighed risks associated with not having a random selection of the general population. The newness and unique qualities of privacy issues in cloud computing are better fitted to a qualitative study where issues can emerge naturally through a holistic approach opposed to trying to force fit an existing set of variables or constructs into the context of privacy and cloud computing.

Practical implications
The findings of this research study can be used to assist management in the process of formulating a cloud privacy policy, develop cloud privacy evaluation criteria as well as assist auditors in developing their privacy audit work plans.

Originality/value
Currently, there is little to no guidance in the literature or in practice as to what organizations need to do to ensure they protect their stakeholders privacy in a cloud computing environment. This study works at closing this knowledge gap by identifying cloud privacy objectives.
Social media, customer engagement and advocacy
Authors: Sashi C.M. , Brynildsen Gina , Bilgihan Anil 
Published: February 2019

PurposeThe purpose of this study is to examine how social media facilitates the process of customer engagement in quick service restaurants (QSRs). Customers characterized as transactional customers, loyal customers, delighted customers or fans, based on the degree of relational exchange and emotional bonds, are expected to vary in their propensity to engage in advocacy and co-create value.Design/methodology/approachHypotheses linking the antecedents of customer engagement to advocacy are empirically investigated with data from the Twitter social media network for the top 50 US QSRs. Multiple regression analysis is carried out with proxies for advocacy as the dependent variable and connection effort, interaction effort, satisfaction, retention effort, calculative commitment and affective commitment as independent variables.FindingsThe results indicate that retention effort and calculative commitment of customers are the most important factors influencing advocacy. Efforts to retain customers using social media communication increase advocacy. Greater calculative commitment also increases advocacy. Affective commitment mediates the relationship between calculative commitment and advocacy.Practical implicationsFostering retention and calculative commitment by using social media communication engenders loyalty and customers become advocates. Calculative commitment fosters affective commitment, turning customers into fans who are delighted as well as loyal, enhancing advocacy.Originality/valueThis study uniquely investigates the relationship between the antecedents of customer engagement and advocacy. It develops the theory and conducts an empirical analysis with actual social media network data for a specific industry where usage of the network is widely prevalent. It confirms that calculative commitment influences advocacy. Calculative commitment not only has a direct effect but also has an indirect effect through affective commitment on advocacy in the QSR context. Further, social media efforts by QSRs to retain customers encourage advocacy. Other customer engagement antecedents do not directly influence advocacy.
Pediatric discharge against medical advice
Authors: Al-Mohammadi Emad 
Published: February 2019

Purpose
The purpose of this paper is to identify the reasons for discharges against medical advice (DAMA) and the possible outcomes among pediatric patients.

Design/methodology/approach
A retrospective cohort study was conducted on all children admitted and then discharged against medical advice in two maternity and children’s hospitals in Jeddah, 2014. Phone interviews were conducted, and medical records were reviewed for DAMA and control groups; a semi-structured questionnaire was used to collect this information.

Findings
The top three reasons identified for DAMA were parent’s false assumption that their child’s condition had improved (43.8 percent), dissatisfaction with treating/managing team (16.2 percent) and difficulties arranging care for patient’s siblings at home (7.7 percent). The readmission rate was significantly higher among DAMA pediatric patients compared to the control group (28.5 percent vs 11.5 percent) at 30-day follow-up, which highlights the importance for developing interventions aimed at reducing DAMA.

Originality/value
This study helps us to better understand DAMA reasons and outcomes. Understanding these factors can encourage appropriate interventions and policies for reducing DAMA rates. In this way, pediatric patients can be protected from inappropriate discharge consequences.
Patient safety culture in Hungarian hospitals
Authors: Granel Nina , Manresa-Domínguez Josep Maria , Barth Anita , Papp Katalin , Bernabeu-Tamayo Maria Dolors 
Published: February 2019

Purpose
The Hospital Survey on Patient Safety Culture (HSOPSC) is a rigorously designed tool for measuring inpatient safety culture. The purpose of this paper is to develop a cross-cultural HSOPSC for Hungary and determine its strengths and weaknesses.

Design/methodology/approach
The original US version was translated and adapted using existing guidelines. Healthcare workers (n=371) including nurses, physicians and other healthcare staff from six Hungarian hospitals participated. Answers were analyzed using exploratory factor analyses and reliability tests.

Findings
Positive responses in all dimensions were lower in Hungary than in the USA. Half the participants considered their work area “acceptable” regarding patient safety. Healthcare staff worked in “crisis mode,” trying to accomplish too much and too quickly. The authors note that a “blame culture” does not facilitate patient safety improvements in Hungary.

Practical implications
The results provide valuable information for promoting a more positive patient safety culture in Hungary and for evaluating future strategies to improve patient safety.

Originality/value
Introducing a validated scale to measure patient safety culture in Hungary improves healthcare quality.
Implementing Lean Six Sigma in a Kuwaiti private hospital
Authors: Al-Zain Yazan , Al-Fandi Lawrence , Arafeh Mazen , Salim Samar , Al-Quraini Shouq , Al-Yaseen Aisha , Abu Taleb Deema 
Published: February 2019

Purpose
The purpose of this paper is to use Lean Six Sigma (LSS) to reduce patient waiting time in a Kuwaiti private hospital obstetrics and gynaecology clinic.

Approach
The define, measure, analyse, improve and control methodology was used. The “define” stage involved identifying patients’ needs, system capabilities and project objectives. The “measure” stage assessed the system’s current state through data collection on waiting times. Dunnett’s test, control charts and process capability analysis were used to ensure data accuracy. In the “analyse” stage, an Ishikawa diagram and Pareto chart were constructed, showing that overbooking appointments, doctors’ unscheduled breaks and doctors not arriving on time were the root causes of the problem. The “improve” stage used an Arena simulation model to represent current and improved system status. The proposed solutions were implemented and monitored in the “control” stage.

Findings
A sigma-level improvement of 300 per cent (0.5–2.0) was realized for appointment patients on Saturdays, with a 67 per cent reduction in waiting time. For walk-ins, the sigma level improved by 288 per cent (0.8–3.1), with a 55 per cent reduction in waiting time. For weekday appointments, the sigma level improved by 111 per cent (0.9–1.9), with a 63 per cent reduction in waiting time. For walk-ins, the sigma level improved by 69 per cent (1.6–2.7), with a 46 per cent reduction in waiting time. A cost–benefit analysis estimated the present project value at $656,459, leading to a total of $5,820,319 in savings by 2025.

Originality/value
This paper fulfils the need for process improvement, increasing patients’ satisfaction and hospitals’ profitability using LSS.
Beyond feedback: understanding how feedforward can support employee development
Authors: Budworth Marie-Hélène , Harrison Jennifer A. , Chummar Sheryl 
Published: February 2019

Purpose
Recent research has found that a technique called feedforward interviewing (FFI) can be used to develop employees on the job. Currently the mechanisms and boundary conditions of the FFI-performance relationship are unexplored. Using a positive psychology framework, the purpose of this paper is to discuss how FFI supports the creation of personal and relational resources, and explores the contextual and environmental limits to the effectiveness of the technique.

Design/methodology/approach
Through a review of the literature as well as examination through appropriate theoretical lenses, moderators of FFI are proposed and the implications for the effectiveness of the technique are examined.

Findings
The FFI model explored in this paper is rooted in broaden and build theory as well as other theories from the positive psychology literature. Design recommendations and future research directions are discussed.

Originality/value
Through a scholarly review of the literature, the potential for the effective use of a new developmental technique is explored. Direct guidance on how to apply FFI in organizations is given.
The moderating effect of emotion regulation on the relationship between risk aversion and brand sensitivity
Authors: Alhosseini Almodarresi Seyed Mahdi , Rasty Fereshte 
Published: February 2019

PurposeThis paper aims to examine the moderating role of positive and negative strategies of emotion regulation on the relationship between risk aversion and brand sensitivity.Design/methodology/approachBy conducting a survey, this study has collected a total of 405 responses and the data have been examined with structural equation modeling.FindingsThe study has demonstrated that some strategies of emotion regulation have a significant moderating effect, and they can down-regulate the effect of risk aversion on brand sensitivity. These strategies are positive refocusing, refocus on planning, positive reappraisal, putting into perspective, acceptance and rumination.Research limitations/implicationsFuture studies should consider a broader range of respondents to validate the results. Moreover, the role of emotion regulation in the relationships among repurchase intention, customer loyalty and customer compliant could be examined. Further research could also focus on the relationship between risk aversion and brand sensitivity with regard to different types of buying situations and consumers’ types.Practical implicationsThe findings demonstrate a substantial implication regarding emotion regulation and brand management. Positive strategies of emotion regulation make risk-averse people less likely to pay attention to brands and lead them to be less brand-sensitive. New companies and businesses could use these findings to make consumers regulate their emotions positively.Originality/valueThis research provides novel findings about the influence of consumers’ emotion regulation on brand sensitivity. People who use positive strategies of emotion regulation tend to dampen the effect of their risk aversion on brand sensitivity and will become less sensitive to the brand.