bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparative Analysis of Neural Crest Development in the Chick and Mouse
Authors: Morrison JA , Pushel I , McLennan R , McKinney MC , Gogol MM , Scott A , Krumlauf R , Kulesa PM 
Published: November 2024

ABSTRACTA core framework of the gene regulatory network (GRN) governing neural crest (NC) cell development has been generated by integrating separate inputs from diverse model organisms rather than direct comparison. This has limited insights into the diversity of genes in the NC cell GRN and extent of conservation of newly identified transcriptional signatures in cell differentiation and invasion. Here, we address this by leveraging the strengths and accessibility of the avian embryo to precise developmental staging by egg incubation and use an integrated analysis of chick (HH13) and mouse (E9.5) embryo tissue samples collected during NC cell migration into pharyngeal arches 1-2 (PA1 and PA2). We successfully identify a cluster of NC cells containing both mouse and chick cells that share expression ofLmo4,Tfap2B,Sox10, andTwist1, and distinct genes that lack known conserved roles in NC. Importantly, we discovered a cluster of cells exhibiting a conserved transcriptional signature associated with the NC cell migratory wavefront in both mouse and chick, including KAZALD1, BAMBI, DES, and GPC3. We confirm their expression is restricted to leader mouse NCs by multiplexed FISH. Together, these data offer novel insights into the transcriptional programs that underlie NC cell migration and establish the foundation for future comparative functional analyses.
Alternative Import-Channels And Destinations Of Mitochondrial PINK1 Controlled By Trans-Membrane-Domain Structural Plasticity
Authors: Lorriman James S. , Grieve Adam G. , Corey Robin A. , Collinson Ian 
Published: November 2024

SummaryEntry of the PINK1-kinase into the mitochondrial inner-membrane results in cleavage by the rhomboid-protease PARL, followed by retro-translocation back to the outer-membrane and proteasomal-degradation. Failure of this process, in compromised mitochondria, leads to kinase activation at the surface, and ultimately mitophagy. Analysis of PINK1-import within intact cells reveals an alternative pathway into the matrix. Structural modelling predicts that PINK1’s trans-membrane-domain (TMD) forms either an α-helix or α/β-hybrid at the interface between Tim17, of the TIM23-core-complex, and, respectively, either Romo1 or PARL. These mutually exclusive interactions both encapsulate a hydrated protein-channel. The α-helical-TMD form adopts a pose suggestive of translocation through the Romo1/Tim17-channel, while the α/β-hybrid-TMD is retracted into PARL’s active-site for cleavage, presumably after import through the adjacent rhomboid/Tim17-channel. We propose structural plasticity of the PINK1-TMD underlies alternative destinies for full-length matrix-import or cleavage/retro-translocation. The results reveal new insights of PINK1’s role in mitochondrial function, quality-control and early-onset Parkinson’s disease.
Membrane asymmetry facilitates murine norovirus entry and persistent enteric infection
Authors: Stewart Brittany M. , Pierce Linley R. , Olson Mikayla C. , Orchard Robert C. 
Published: November 2024

AbstractNorovirus, the leading cause of gastroenteritis worldwide, is a non-enveloped virus whose tropism is determined in part by the expression patterns of entry receptors. However, the contribution of cellular lipids to viral entry is not well understood. Here, we determined that the asymmetrical distribution of lipids within membrane bilayers is required for murine norovirus (MNV) replication. Specifically, TMEM30a, an essential subunit of lipid flippases, is required for MNV replication in vitro. Disruption of TMEM30a in mouse intestinal epithelial cells prevents persistent, enteric infection by MNV in vivo. Mechanistically, TMEM30a facilitates MNV binding and entry. Surprisingly, exoplasmic phosphatidylserine (PS), a typical marker of dying cells, does not inhibit MNV infection. Rather, TMEM30a maintains a lipid ordered state that impacts membrane fluidity that is necessary for the low affinity, high avidity binding of MNV to cells. Our data provides a new role for lipid asymmetry in promoting non-enveloped virus infectionin vitroand norovirus persistence in vivo.
“Randomized controlled clinical trial with a multifaceted cognitive training program using video games in childhood cancer survivors”
Authors: González-Pérez Carlos , Fernández-Jiménez Eduardo , Morán Elena , Melero Helena , Malpica Norberto , Álvarez-Linera Juan , Puig Mario Alonso , Plaza Diego , Pérez-Martínez Antonio 
Published: November 2024

1AbstractThis randomized controlled trial aims to evaluate the efficacy of a cognitive training program using video games in improving neuropsychological, neurological, immunological, and inflammatory parameters in childhood cancer survivors. This study will recruit 56 patients aged 8-17 years who have completed cancer treatment 1-7 years prior to enrollment. Participants will be randomized to either the video game intervention or waiting group. The primary objectives are analyzing potential changes in neuropsychological tests covering all neurocognitive domains, neuroimaging tests (structural, diffusion, and functional imaging), and immune and inflammatory biomarker levels after video game intervention. The secondary objectives are to define the prevalence of neurocognitive deficits in the study population, analyze psychological and emotional self-perception and parental perception after the intervention, and assess the feasibility of implementing this new intervention methodology. The inclusion criteria comprise specific diagnoses (CNS cancer, hematologic malignancies, extracranial solid tumors, and nonmalignant hematological diseases requiring allogeneic hematopoietic progenitor transplantation) and treatments (CNS surgery, radiotherapy, intrathecal/intraventricular chemotherapy, neurotoxic systemic chemotherapy, and hematopoietic stem cell transplantation). Patients with active disease, relapse, or prior neurological or psychiatric pathology will be excluded. This study will improve the understanding and management of neurocognitive sequelae in childhood cancer survivors and ultimately enhance their quality of life.
Recurrent Connectivity Shapes Spatial Coding in Hippocampal CA3 Subregions
Authors: Kong Eunji , Zabeh Erfan , Liao Zhenrui , Mihaila Tiberiu S. , Wilson Caroline , Santhirasegaran Charan , Peterka Darcy S. , Losonczy Attila , Geiller Tristan 
Published: November 2024

AbstractStable and flexible neural representations of space in the hippocampus are crucial for navigating complex environments. However, how these distinct representations emerge from the underlying local circuit architecture remains unknown. Using two-photon imaging of CA3 subareas during active behavior, we reveal opposing coding strategies within specific CA3 subregions, with proximal neurons demonstrating stable and generalized representations and distal neurons showing dynamic and context-specific activity. We show in artificial neural network models that varying the recurrence level causes these differences in coding properties to emerge. We confirmed the contribution of recurrent connectivity to functional heterogeneity by characterizing the representational geometry of neural recordings and comparing it with theoretical predictions of neural manifold dimensionality. Our results indicate that local circuit organization, particularly recurrent connectivity among excitatory neurons, plays a key role in shaping complementary spatial representations within the hippocampus.
SMAS: Structural MRI-Based AD Score using Bayesian VAE
Authors: Nemali A. , Bernal J. , Yakupov R. , Singh D. , Dyrba M. , Incesoy E.I. , Mukherjee S. , Peters O. , Hellmann-Regen J. , Ersözlü E. , Preis L. , Priller J. , Spruth E. , Altenstein S. , Lohse A. , Schneider A. , Fliessbach K. , Kimmich O. , Wiltfang J. , Hansen N. , Schott B. , Rostamzadeh A. , Glanz W. , Butryn M. , Buerger K. , Janowitz D. , Ewers M. , Perneczky R. , Rauchmann B. , Teipel S. , Kilimann I. , Goerss D. , Laske C. , Sodenkamp S. , Spottke A. , Coenjaerts M. , Brosseron F. , Lüsebrink F. , Dechent P. , Scheffler K. , Hetzer S. , Kleineidam L. , Stark M. , Jessen F. , Duzel E. , Ziegler G. 
Published: November 2024

AbstractThis study introduces the Structural MRI-based Alzheimer’s Disease Score (SMAS), a novel index intended to quantify Alzheimer’s Disease (AD)-related morphometric patterns using a deep learning Bayesian-supervised Variational Autoencoder (Bayesian-SVAE). SMAS index was constructed using baseline structural MRI data from the DELCODE study and evaluated longitudinally in two independent cohorts: DEL-CODE (n=415) and ADNI (n=190). Our findings indicate that SMAS has strong associations with cognitive performance (DELCODE: r=-0.83; ADNI: r=-0.62), age (DEL-CODE: r=0.50; ADNI: r=0.28), hippocampal volume (DEL-CODE: r=-0.44; ADNI: r=-0.66), and total grey matter volume (DELCODE: r=-0.42; ADNI: r=-0.47), suggesting its potential as a biomarker for AD-related brain atrophy. Moreover, our longitudinal studies suggest that SMAS may be useful for early identification and tracking of AD. The model demonstrated significant predictive accuracy in distinguishing cognitively healthy individuals from those with AD (DELCODE: AUC=0.971 at baseline, 0.833 at 36 months; ADNI: AUC=0.817 at baseline, improving to 0.903 at 24 months). Notably, over a 36-month period, SMAS index outperformed existing measures such as SPARE-AD and hippocampal volume. Relevance map analysis revealed significant morphological changes in key AD-related brain regions—including the hippocampus, posterior cingulate cortex, precuneus, and lateral parietal cortex—highlighting that SMAS is a sensitive and interpretable biomarker of brain atrophy, suitable for early AD detection and longitudinal monitoring of disease progression.
Axonal injury signaling is restrained by a spared synaptic branch
Authors: Smithson Laura J. , Zang Juliana , Junginger Lucas , Waller Thomas J. , Jankowiak Reilly , Khan Sophia , Li Ye , Cai Dawen , Collins Catherine A. 
Published: November 2024

AbstractThe intrinsic ability of injured neurons to degenerate and regenerate their axons facilitates nervous system repair, however this ability is not engaged in all neurons and injury locations. Here we investigate the regulation of a conserved axonal injury response pathway with respect to the location of damage in branched motoneuron axons inDrosophilalarvae. The dileucine zipper kinase DLK, (also known as MAP3K12 in mammals and Wallenda (Wnd) inDrosophila), is a key regulator of diverse responses to axonal injury. In three different populations of motoneurons, we observed the same striking result that Wnd/DLK signaling becomes activated only in response to injuries that remove all synaptic terminals. Injuries that spare even a small part of a synaptic terminal fail to activate Wnd/DLK signaling, despite the presence of extensive axonal degeneration. The regulation of injury-induced Wnd/DLK signaling occurs independently of its previously known regulator, the Hiw/PHR ubiquitin ligase. We propose that Wnd/DLK signaling regulation is linked to the trafficking of a synapse-to-nucleus axonal cargo and that this mechanism enables neurons to respond to impairments in synaptic connectivity.
Exploring structure-function relationships in engineered receptor performance using computational structure prediction
Authors: Corcoran William K. , Cosio Amparo , Edelstein Hailey I. , Leonard Joshua N. 
Published: November 2024

AbstractEngineered receptors play increasingly important roles in transformative cell-based therapies. However, the structural mechanisms that drive differences in performance across receptor designs are often poorly understood. Recent advances in protein structural prediction tools have enabled the modeling of virtually any user-defined protein, but how these tools might build understanding of engineered receptors has yet to be fully explored. In this study, we employed structural modeling tools to perform post hoc analyses to investigate whether predicted structural features might explain observed functional variation. We selected a recently reported library of receptors derived from natural cytokine receptors as a case study, generated structural models, and from these predictions quantified a set of structural features that plausibly impact receptor performance. Encouragingly, for a subset of receptors, structural features explained considerable variation in performance, and trends were largely conserved across structurally diverse receptor sets. This work indicates potential for structure prediction-guided synthetic receptor engineering.
Topological magnon in exchange frustration driven incommensurate spin spiral of kagome-lattice
YMn6Sn6
Authors: Sadhukhan Banasree , Bergman Anders , Thunström Patrik , Lopez Manuel Pereiro , Eriksson Olle , Delin Anna 
Published: November 2024

YMn6Sn6 consists of two types of Mn-based kagome planes stacked along the c-axis having a complex magnetic interaction. We report a spin reconstruction in YMn6Sn6 from ferromagnetic (FM) into a combination of two incommensurate spin spirals (SSs) originating from two different types of Mn kagome planes driven by frustrated magnetic exchanges along the c-axis with the inclusion of the Hubbard U. The pitch angle and wave vector of the incommensurate SSs are ∼89.3∘ and ∼ (0 0 0.248), respectively, which are in excellent agreement with the experiment. We employ an effective model Hamiltonian constructed out of exchange interactions to capture the experimentally observed nonequivalent nature of the two incommensurate SSs which also explain the FM-SS crossover due to antiferromagntic spin exchange with correlation. We further report the existence of a topological magnon with spin-orbit coupling in the incommensurate SS phase of YMn6Sn6 by calculating the topological invariants and Berry curvature profile. The location of the Dirac magnon in the energy landscape at 73 meV matches with another experimental report. We demonstrate the accuracy of our results by highlighting the experimental features in YMn6Sn6.

Published by the American Physical Society
2024
Production mechanism of the hidden charm pentaquark states
Pcc¯
Authors: Clymton Samson , Kim Hyun-Chul , Mart Terry 
Published: November 2024

We investigate hidden charm pentaquark states using an off-shell coupled-channel formalism involving heavy meson and singly heavy baryon scattering. Our approach utilizes an effective Lagrangian to construct the kernel amplitudes, which respect both heavy quark symmetry and hidden local symmetry. After solving the coupled integral equations, we obtain the transition amplitudes for J/ψN scattering and various heavy meson and singly heavy baryon scattering processes. We identify seven distinct peaks related to molecular states of heavy mesons D¯ (D¯*) and singly heavy baryons Σc (Σc*). Four of these peaks can be associated with the known Pcc¯ states: Pcc¯(4312), Pcc¯(4380), Pcc¯(4440), and Pcc¯(4457). We predict two additional resonances with masses around 4.5 GeV, which we interpret as D¯*Σc* molecular states, and identify one cusp structure. Additionally, we predict two P-wave pentaquark states with positive parity, which may be candidates for genuine pentaquark configurations. Notably, these pentaquark states undergo significant modifications in the J/ψN elastic channel, with some even disappearing due to interference from the positive parity channel. The present investigation may provide insight into the absence of pentaquark states in J/ψ photoproduction observed by the GlueX Collaboration.

Published by the American Physical Society
2024
Separated reactant mix width across diffusion-dominated and hydrodynamically dominated interface mix in inertial confinement fusion implosions
Authors: Meaney K. D. , Kim Y. , Hoffman N. M. , Mohamed Z. L. , Taitano W. T. , Herrmann H. W. , Geppert-Kleinrath H. , Springstead M. P. , Zylstra A. B. , Leatherland A. , Wilson L. , Glebov V. Yu. , Forrest C. 
Published: November 2024

Diffusion-dominated mix in inertial confinement fusion (ICF) is characterized where the majority of the mix occurs in the immediate fuel-shell interface while hydrodynamic-dominated mix pulls shell material from farther away into the central fuel. A thin (150 nm) separated reactants ICF mix platform is highly sensitive to the amount of mix from the first micron of shell-fuel interface. This fine-spatial resolution platform has revealed that material mix in moderate convergence (CR∼12) ICF implosions is dominated by a diffusion mechanism. This technique has now been expanded across a set of OMEGA ICF implosions, observing an increase in mix width and mix amount for cooler, slower, and more compressive implosions. Hydrodynamic simulations require a buoyancy-drag mix model to capture the increasing mix width, suggesting a transition between these two mix mechanisms.

Published by the American Physical Society
2024
Management information systems and organizational agility: a bibliometric analysis
Authors: Hameed Ibrahim Mohammed , Singla Jagdeep , Goel Ridhima 
Published: November 2024

Purpose
This paper aims to complex relationship between management information systems (MIS) and organizational agility, identifying gaps and key themes to guide future research in this domain.

Design/methodology/approach
A systematic extraction of 578 relevant articles from the Scopus database was conducted to provide an in-depth bibliometric analysis of the evolving role of MIS in enhancing organizational agility. Data analysis and visualization were performed using R Studio and VOSviewer.

Findings
The analysis highlights significant publication trends and identifies leading countries, institutions and journals in MIS and organizational agility research. Collaborative efforts from nations such as the USA, China and the UK, were prominent, focusing on information technology alignment, strategic agility and big data analytics. This study delineates distinct research clusters and future research questions, offering a clear trajectory for ongoing exploration in the field.

Originality/value
To the best of the authors’ knowledge, this study is one of the first to provide a comprehensive bibliometric analysis of the intersection between MIS and organizational agility. It offers valuable insights into research trends and future directions while emphasizing the need for MIS deployment, thereby contributing to a comprehensive understanding of the field.
Enhancing efficiency through negotiation and minimizing transaction costs: application of Coase theorem to corporate insolvency
Authors: Thakkar Hiteshkumar , Agarwal Pranay 
Published: November 2024

Purpose
Coase theorem is more interested in increasing the economic value of the transaction through a libertarian approach, i.e. free bargain than a utilitarian approach, i.e. maximum benefit to a maximum number of people. Ex ante Corporate Insolvency Resolution Process (CIRP) ensured that the stakeholders would arrive at an efficient outcome through bargaining and negotiation regardless of the initial allocation of legal rights. It also minimizes transaction costs to facilitate a voluntary resolution/settlement process; otherwise, it is costly to determine how much stakeholder value the same. The purpose of this study is to examine how the Coase theorem can enhance efficiency in corporate insolvency by facilitating effective bargaining and negotiation among stakeholders, minimizing transaction costs and ensuring optimal outcomes, regardless of the initial allocation of legal rights.

Design/methodology/approach
This research relies on a mixed method – quantitative data and qualitative data from the relevant stakeholders in the CIRP to verify the Coase theorem in the real world. The quantitative data collection involves a sample of 103 individuals categorized into three groups: advocates (71 participants), creditors (five participants) and resolution professionals (RPs) (27 participants). Qualitative data collection involves conducting personal interviews (PI) as the primary method, supplemented by panel discussions and observations during National Company Law Tribunal proceedings.

Findings
Insolvency and Bankruptcy Code (IBC) helps creditors to recover their dues through a cost-efficient ex ante CIRP process. The structure of IBC is to minimize the harm caused by the failure of a private agreement/settlement. However, when private negotiation/settlement fails, the insolvency law allocates the rights to the party who values them most. The CIRP process has prioritised the economic principle of high-value ownership, thus allocating the rights to the higher-value owner.

Practical implications
This study focuses on practitioner responses within the CIRP, including practical insights from advocates, creditors and RPs.

Originality/value
The IBC has substantially reduced transaction costs by streamlining provisions and imposing stringent timelines to facilitate smoother negotiations. CIRP is a unique mechanism that provides a group solution while maintaining the balance between the stakeholders’ welfare and the process’s efficiency.
Islamic banking finance and private sector investment in dual banking systems: the impact of institutional quality
Authors: Ben Mimoun Mohamed , Hamrouni Daghbagi , Raies Asma 
Published: November 2024

Purpose
This study aims to examine the role of Islamic Banking (IB) finance in promoting private sector investment within dual banking systems, with particular attention to the impact of institutional quality.

Design/methodology/approach
Using panel data from 26 countries with dual banking systems over the 2004–2022 period, this study uses the system-GMM estimator to analyze the interaction between private investment, IB finance and institutional quality, using both aggregated and disaggregated institutional quality indicators.

Findings
The results indicate that the direct effect of IB finance on private investment is generally limited across the sample. However, institutional quality, while showing a negative standalone effect, plays a pivotal role when considered interactively with IB finance. This study demonstrates that when both IB finance and institutional quality reach certain threshold levels, they exhibit a complementary relationship that significantly enhances private sector investment. The thresholds and key economic factors that influence private investment in the studied countries are estimated, providing valuable policy implications.

Originality/value
This research provides new insights into the interplay between IB finance and institutional quality, emphasizing that the effectiveness of IB finance is conditional upon strong institutional frameworks. Unlike previous studies, the work redefines the finance-growth nexus in dual banking systems, demonstrating that institutional improvements are essential to unlocking the full potential of IB finance.