bluuebunny/crossref_metadata_2025_split huggingface dataset:
Traditional Chinese medicine on treating premature ejaculation
Authors: Li Yongqiang , Duan Yunyun , Yu Xudong , Wang Jisheng , Yao Zeyu , Gong Xihao , Gong Xiaoyong , Zheng Wei , Xue Yahui , Guo Jianen 
Published: May 2019

Abstract

Background:
Premature ejaculation is a form of male sexual dysfunction. As people's lifestyle changes and the population ages, the incidence of premature ejaculation continues to increase. Many clinical trials have proven that Chinese medicine has a significant effect in the treatment of premature ejaculation. In this systematic review, we aim to evaluate the effectiveness and safety of Traditional Chinese medicine for premature ejaculation.

Methods:
We will search for PubMed, Cochrane Library, AMED, EMbase, WorldSciNet; Nature, Science online and China Journal Full-text Database (CNKI), China Biomedical Literature CD-ROM Database (CBM), and related randomized controlled trials included in the China Resources Database. The time is limited from the construction of the library to April 2019. We will use the criteria provided by Cochrane 5.1.0 for quality assessment and risk assessment of the included studies, and use the Revman 5.3 and Stata13.0 software for meta-analysis of the effectiveness, recurrence rate, and symptom scores of premature ejaculation.

Ethics and dissemination:
This systematic review will evaluate the efficacy and safety of Traditional Chinese medicine for treating premature ejaculation. Because all of the data used in this systematic review and meta-analysis has been published, this review does not require ethical approval. Furthermore, all data will be analyzed anonymously during the review process Trial.

Trial registration number:
PROSPERO CRD42017065316
Application of a real-time 3-dimensional navigation system for treatment of synovial chondromatosis of the temporomandibular joint
Authors: Matsuda Shinpei , Yoshimura Hitoshi , Sano Kazuo 
Published: May 2019

Abstract

Rationale:
Real-time three-dimensional navigation systems can provide useful information for operators during surgery. The authors report a case of synovial chondromatosis of the temporomandibular joint treated by open surgery under the guidance of a real-time 3-dimensional navigation system with a 3-point rigid cranial fixation device.

Patient concerns:
A 73-year-old woman presented with swelling in the left preauricular region and left temporomandibular joint pain.

Diagnoses:
The patient was diagnosed with synovial chondromatosis of the temporomandibular joint by imaging examinations.

Interventions:
The patient was treated by open surgery under the guidance of a real-time 3-dimensional navigation system with a 3-point rigid cranial fixation device.

Outcomes:
The patient was diagnosed with synovial chondromatosis by histopathological examination. There were no complications. The real-time 3-dimensional navigation system with a 3-point rigid cranial fixation device provided an accurate and useful navigation image and clear surgical field during the surgical procedure. Thirty months have passed since the operation without clinical findings associated with recurrence.

Lessons:
The guidance provided by a real-time 3-dimensional navigation system with a 3-point rigid cranial fixation device is useful in open surgery for the treatment of synovial chondromatosis of the temporomandibular joint.
The effects of ultrasound-guided serratus plane block, in combination with general anesthesia, on intraoperative opioid consumption, emergence time, and hemodynamic stability during video-assisted thoracoscopic lobectomy
Authors: Lee Jungwon , Kim Saeyoung 
Published: May 2019

Abstract

Background:
Thoracotomy is one of the most painful surgeries; therefore, video-assisted thoracoscopic surgery (VATS) was developed to reduce the surgical stress of thoracotomy. Although VATS results in reduced postoperative pain compared with thoracotomy, it is still painful. Serratus plane block (SPB) is a novel technique that provides lateral chest wall analgesia by blocking the lateral branch of the intercostal nerve.

Methods:
We conducted a prospective study in 50 patients, aged 20 to 75 years, undergoing three-port VATS lobectomy. Group G (n = 25) received conventional general anesthesia and Group S (n = 25) received SPB before induction of general anesthesia. In Group S, 20 ml of 0.375% ropivacaine was injected between the serratus anterior and latissimus dorsi muscles. During surgery, anesthesia was maintained by adjusting the propofol dose to maintain a bispectral index of 40 to 60 and the remifentanil dose to maintain blood pressure and heart rate within 70 to 130% of baseline.

Results:
Intraoperative remifentanil consumption was significantly lower in Group S compared to that in Group G (519.9 μg vs 1047.7 μg, P < .001). Moreover, emergence time was significantly shorter in Group S compared to Group G (10.8 minutes vs 14.9 minutes, P = .01). However, there were no significant differences in systolic blood pressure and heart rate (HR) between the groups at each time point. The doses of rescue drugs for the control of blood pressure and HR were not significantly different between the 2 groups.

Conclusions:
Ultrasound-guided SPB could be a safe and effective regional anesthesia technique for VATS
The effect of anti-gravity treadmill training for knee osteoarthritis rehabilitation on joint pain, gait, and EMG
Authors: Liang Junjie , Lang Shijuan , Zheng Yuxin , Wang Yujue , Chen Hongxin , Yang Jinyu , Luo Zhiwei , Lin Qiang , Ou Haining 
Published: May 2019

Abstract

Introduction:
To date, the anti-gravity treadmill (AlterG), as a representative method of Lower body positive pressure (LBPP) treadmills, has been rarely reported for knee osteoarthritis (KOA) rehabilitation. The purpose of this case study was to setup the clinical protocol example for AlterG intervention on KOA and evaluate treatment effectiveness by 3D gait analysis combined with free EMG to explore the kinematic gait parameter changes.

Patient concerns:
A 65-year-old female patient (BMI = 26, mild obesity) undergoing “more than 7 years of KOA.” The activity of the right knee joint was obviously limited and she suffered from severe pain over the past month.

Diagnosis:
Due to the patient's symptoms and radiographic findings, she was diagnosed with acute attack of KOA.

Interventions:
The patient has performed clinical function evaluation and gait analysis combined at pretreatment, post-treatment, and 4 months follow-up assessment. AlterG training was performed 6 days/week for 2 weeks, with up to 30 min of training per session. The training protocol included two major parts, walking and squatting in AlterG.

Outcomes:
After 2 weeks of AlterG intervention, the 10-m walking test (10 MWT) and Timed-up-and-go (TUG) test improved significantly post-treatment, whereas the Visual Analog Scale (VAS) score decreased post-treatment. The Modified Barthel Index improved post-treatment and the patient restored basic community walk after treatment. The temporal parameter results showed that stride length (%height), mean velocity (%height), and cadence gradually increased before treatment, after treatment, and at 4-month follow-up. The right range of motion (ROM) of knee flexion-extension were gradually increased. Meanwhile, the synchronized EMG data showed that the RMS (root means square) values of the rectus femoris, semitendinosus, and biceps femoris at post-treatment were improved to different degrees than at pretreatment.

Conclusion:
We found that for this patient with KOA, AlterG relieved pain, and was also effective at improving spatio-temporal parameters, knee flexion/extension gait pattern, and corresponding muscle strength, thereby restoring certain community activities.
Effects of vitamin D supplementation on cardiovascular risk factors in shift workers
Authors: Fajardo Virginia Capistrano , de Oliveira Fernando Luiz Pereira , Machado-Coelho George Luiz Lins , Pimenta Fausto Aloísio Pedrosa , de Freitas Silvia Nascimento , Ribeiro Antônio Luiz Pinho , Soares Maria Marta Sarquis , Lauria Marcio Weissheimer , Farias Rosielle da Costa , França Ive Bahia , do Nascimento Neto Raimundo Marques 
Published: May 2019

Abstract

Objective:
The present clinical study aims to describe protocol to evaluate the effects of vitamin D3 supplementation on the cardiovascular risk factors in a population of rotating shift workers.

Design:
A randomized, double-blind, placebo-controlled, parallel group clinical trial testing 2 oral dosages of cholecalciferol (14,000 IU and 28,000 IU per week) for 12 months.

Setting:
The primary outcome for evaluation is an 18% reduction in hypertriglyceridemia (≥150 mg/dL) between pre and postintervention measurements. Baseline characteristics of the study population will be summarized separately within each randomized group, and will use tests for continuous and categorical variables. For all tests, a P < .05 will be considered significant. The analysis of primary and secondary outcomes will use an intention-to-treat population and a per-protocol population. The primary and secondary outcomes will be compared separately between each treatment group and placebo, using binary logistic regression or regressão de Poisson for proportions (for binary outcomes) and using linear regression for differences in means (for continuous endpoints), with 95% confidence intervals.

Participants:
Rotating shift workers, adults aged between 18 and 60 years, with hypovitaminosis D and alterations in at least 1 of the following parameters: fasting glucose, high-density lipoprotein cholesterol, triglycerides, low-density lipoprotein cholesterol, blood pressure, and waist circumference.

Conclusion:
This clinical trial aims to contribute to the gap in knowledge about the potential, dose, and time of vitamin D supplementation to generate beneficial effects on triglycerides in a population at increased risk for hypertriglyceridemia and vitamin D deficiency.
Urachal remnant with heterotopic sinus in an adult male
Authors: Sun Zhao-Hui , Kong Xiang-Hui , Huang Wen-Jie , Chen Gang , Huang Xiao-Jun 
Published: May 2019

Abstract

Introduction:
Urachal remnant with heterotopic sinus is an extremely rare congenital anomaly, and usually coexists with other congenital anomalies. We report the case of a 32-year-old adult male with urachal remnant with heterotopic sinus.

Patient concerns:
A 32-year-old adult male presented with purulent secretion in the heterotopic sinus on the dorsal side of the normal external urethral orifice and pain in the balanus since 5 months.

Diagnosis:
The computed tomography scan demonstrated a 4 cm cystic mass next to the anterior wall of the urinary bladder. Retrograde urethrography was performed, which demonstrated that this mass communicated with the heterotopic sinus on the dorsal side of the normal external urethral orifice. Cystoscopy showed that there was no communication between the mass and the bladder. Pathology results confirmed that this mass was urachal tissue.

Interventions:
The patient underwent a laparoscopy surgery to undertake the cystic mass, part of the anterior wall of urinary bladder and the epithelium of channel which communicated with the cystic mass.

Outcomes:
The patient was discharged without any complications after 6 months and follow-up was continued in the clinic.

Conclusions:
Urachal remnant with heterotopic sinus is rare, and we recommend that urachal remnant should be considered when a patient presents with a mass in the retropubic space.
Successful removal of multiple magnetic foreign bodies in the digestive tract of children by gastroscopy
Authors: Lyu Xintong , Pi Zhuang , Wang Zhaoxia , Wu Lan , Wang Libo , Pang Xiaoli 
Published: May 2019

Abstract

Rationale:
Gastrointestinal foreign body (FB) is an emergency commonly encountered by the pediatric gastroenterology department. Management of their extraction requires knowledge and careful consideration of removal techniques.

Patient concerns:
Two little girls swallowed multiple magnets that stuck together for >3 days, which was an indication for surgery.

Diagnosis:
X-ray revealed dense shadows in the left abdomen. However, the abdominal examination revealed a soft abdomen without tenderness, rebound tenderness, or muscle rigidity.

Intervention:
The multiple magnets were removed by endoscopy instead of surgery.

Outcome:
We conducted sufficient preoperative assessment and preparation. Eventually, we successfully removed the multiple magnets by endoscopy, and no perforation or fistula formation was observed. Surgery was avoided.

Lessons:
Swallowing multiple magnets isn’t a rare emergency in children. Physicians must be aware that surgery is not the only option even if multiple magnets are swallowed for >12 hours. Endoscopic removal can be considered if there is no obstruction, perforation, or fistula formation upon careful patient assessment. If endoscopic removal fails, surgical treatment should be performed as soon as possible to avoid serious complications.
Cerebral arterial air embolism after computed tomography-guided hook-wire localization of a pulmonary nodule
Authors: Wang Ming-Yi , Liu Yong-Sheng , An Xiang-Bo , Li Ke , Liu Yong-Jian , Wang Feng 
Published: May 2019

Abstract

Rationale:
Cranial arterial air embolism is a rare but potentially fatal complication after computed tomography (CT)-guided pulmonary interventions.

Patient concerns:
A 64-year-old man was diagnosed with a pulmonary nodule (diameter: approximately 1 cm) in the right lower lobe. The patient developed convulsions after CT-guided hook-wire localization.

Diagnosis:
Cranial CT revealed arborizing/linearly distributed gas in the territory of the right middle cerebral artery.

Interventions:
The patient was administered hyperbaric oxygen, antiplatelet aggregation therapy, and dehydration treatment.

Outcomes:
Clinical death occurred 55 hours after air embolism.

Lessons:
Systemic air embolism is a serious complication of lung puncture. Clinicians should improve their understanding of this complication and remain vigilant against air embolism.
Traumatic lumbar disc herniation mimicking epidural hematoma
Authors: Kim Ju-Hwi , Kim Soo-Han , Lee Seul-Kee , Moon Bong Ju , Lee Jung-Kil 
Published: May 2019

Abstract

Rationale:
We report a rare case of traumatic lumbar disc herniation mimicking epidural hematoma.

Patient concerns:
A 39-year old man presented with acute bilateral leg and back pain, following a crushing injury caused by a crane collapse.

Diagnosis:
A computed tomography scan revealed multiple compression fractures of the thoracolumbar spine, including a burst fracture of the L4 vertebral body. Magnetic resonance imaging (MRI) showed an epidural mass, extending longitudinally and causing dural sac compression behind the L3 vertebra. The mass had isosignal intensity on T1-weighted imaging and showed mixed high and low signals on T2-weighted imaging. On the basis of the patient's clinical history and imaging findings, our provisional diagnosis was an epidural hematoma following major trauma.

Interventions:
An emergency L3 laminectomy was performed with percutaneous screw fixation of L3-5. Intraoperatively, 3 large herniated disc fragments were found at L3 with no evidence of hematoma.

Outcomes:
The patient recovered normal motor function after surgery. At the last follow-up, 3 years after surgery, there was no residual neurological deficit apart from intermittent lower back pain.

Lessons:
In cases where MRI findings reveal an epidural lesion with a longitudinal shape, similar to an epidural hematoma, with mixed signal intensity on T2-weighted images and high peripheral signal intensity on T1-weighted images, traumatic disc herniation should be included in the differential diagnosis.
Radiomics features analysis of PET images in oropharyngeal and hypopharyngeal cancer
Authors: Liao Ken Ying-Kai , Chiu Chuang-Chien , Chiang Wan-Chi , Chiou Yu-Rou , Zhang Geoffrey , Yang Shih-Neng , Huang Tzung-Chi 
Published: May 2019

Abstract
This study used radiomics image analysis to examine the differences of texture feature values extracted from oropharyngeal and hypopharyngeal cancer positron emission tomography (PET) images on various tumor segmentations, and finds the proper and stable feature groups. A total of 80 oropharyngeal and hypopharyngeal cancer cases were retrospectively recruited. Radiomics method was applied to the PET image for the 80 oropharyngeal and hypopharyngeal cancer cases to extract texture features from various defined metabolic volumes. Kruskal-Wallis one-way analysis of variance method was used to test whether feature value difference exists between groups, which were grouped by stage, response to treatment, and recurrence. If there was a significant difference, the corresponding feature cutoff value was applied to the Kaplan–Meier estimator to estimate the survival functions. For the various defined metabolic volumes, there were 16 features that had significant differences between early (T1, T2) and late tumor stages (T3, T4). Five images and 2 textural features were found to be able to predict the tumor response and recurrence, respectively, with the areas under the receiver operating characteristic curves reaching 0.7. The histogram entropy was found to be a good predictor of overall survival (OS) and primary relapse-free survival (PRFS) of oropharyngeal and hypopharyngeal cancer patients. Textural features from PET images provide predictive and prognostic information in tumor staging, tumor response, recurrence, and have the potential to be a prognosticator for OS and PRFS in oropharyngeal and hypopharyngeal cancer.
Pleural effusion as a substitute for tumor tissue in detecting EGFR/ALK mutations in non-small cell lung cancer
Authors: Pang Caishuang , Ma Huiwen , Qin Jiangyue , Wang Sixiong , Wan Chun , Yang Ting , Shen Yongchun , Wang Donglin 
Published: May 2019

Abstract

Background:
Pleural effusion (PE) has been reported useful in many studies for testing epidermal growth factor receptor (EGFR) mutations in non-small cell lung cancer (NSCLC) with variable results. This systematic review and meta-analysis was performed to elucidate whether PE could be used as a surrogate for tumor tissue to detect EGFR mutations.

Methods:
We extracted 2 × 2 diagnostic table from each included study and calculated data on specificity, sensitivity, negative likelihood ratio (NLR), positive likelihood ratio (PLR) ,and diagnostic odds ratio (DOR). We used the area under curve (AUC) and summary receiver operating characteristic curve (SROC) to summarize the overall diagnostic performance and assessed publication bias by Deeks’ funnel plot.

Results:
Our meta-analysis included 15 eligible publications. The following summary estimates for diagnostic parameters of the EGFR mutations detection in PE were made: sensitivity, 0.86 (95%CI 0.83–0.89); specificity, 0.93 (95%CI 0.91–0.95); PLR, 8.53 (95%CI 5,94–12.25); NLR, 0.18 (95%CI 0.13–0.25); DOR, 63.40 (95%CI 38.83–103.51); and AUC, 0.94. Funnel plot indicated publication bias insignificant.

Conclusions:
The meta-analysis suggests that EGFR mutation detecting in PE, especially supernatants, is a promising surrogate for tumor tissue in EGFR mutations testing of patients with NSCLC.
Changes of intraocular pressure and ocular perfusion pressure during controlled hypotension in patients undergoing arthroscopic shoulder surgery
Authors: Kim Yong-Shin , Han Na-Re , Seo Kwon Hui 
Published: May 2019

Abstract

Purpose:
The aim of the present study is to evaluate the effects of deliberate hypotensive anesthesia on intraocular pressure (IOP) and ocular perfusion pressure (OPP) and compare the effects of propofol total intravenous anesthesia (TIVA) and desflurane anesthesia on IOP and OPP.

Methods:
A total of 50 patients undergoing arthroscopic shoulder surgery in the lateral decubitus position were randomized to receive desflurane or propofol anesthesia. Mean arterial pressure (MAP) was maintained in the range of 60–75 mm Hg during hypotensive anesthesia. IOP was measured using a handheld tonometer at 7 time points: before induction (T1, baseline); immediately after endotracheal intubation (T2); 10 minutes after position change to lateral decubitus (T3); 10, 30, and 50 minutes after the start of hypotensive anesthesia (T4–T6); and at the end of surgery (T7).

Results:
MAP decreased about 35% to 38% during hypotensive anesthesia. Compared to baseline values, the IOP at T6 in dependent and non-dependent eyes decreased by 0.43 and 2.74 mm Hg, respectively in desflurane group; 3.61 and 6.05 mm Hg, respectively in the propofol group. IOP of both eyes in the propofol group was significantly lower than in the desflurane group from T2 to T7. OPP of both eyes in both groups was significantly lower than at baseline, except at T2 in the desflurane group. OPP of both eyes in the propofol group was significantly higher than that in the desflurane group at T5 and T6.

Conclusions:
Hypotensive anesthesia reduced IOP and OPP, but propofol TIVA maintained higher OPP than desflurane anesthesia. These findings suggest that propofol TIVA can help mitigate the decrease of OPP during hypotensive anesthesia.
Predictive value of serum uric acid levels for adverse perinatal outcomes in preeclampsia
Authors: Ryu Aelie , Cho Nam Jun , Kim Yun Sook , Lee Eun Young 
Published: May 2019

Abstract
Preeclampsia is a multisystem disorder associated with pregnancy and is a common cause of perinatal morbidity. The aim of this study was to determine whether elevated serum uric acid levels, alone or in combination with other laboratory factors could predict preeclampsia in women with adverse perinatal outcomes.
We conducted a prospective observational study of women who were admitted to Soonchunhyang University Cheonan Hospital from January 2016 to December 2016. Demographic, clinical and laboratory data were collected for each pregnancy at the time of delivery. Women were grouped according to status (preeclampsia or normotensive), and a logistic regression analysis was used to determine the relationship between serum uric acid levels and adverse outcomes.
The mean age of the study participants was 31.3 ± 5.0 years. In patients with preeclampsia, serum uric acid level was associated with the severity of preeclampsia, including blood pressure (R = 0.321, P = .014), serum creatinine levels (R = 0.505, P < .001), and proteinuria (P = .014), as well as adverse fetal outcomes, including preterm labor (P = .027) and low birth weight delivery (P = .001). The optimal maternal serum uric acid threshold that predicted low birth weight at delivery was 6.35 mg/dL (sensitivity, 0.58; specificity, 0.95). The multivariable logistic regression model that was used to predict low birth weight at delivery displayed an area under the receiver-operating characteristic curve of 0.902 (95% confidence interval, 0.817–0.986).
In women with preeclampsia, maternal serum uric acid level is an important parameter for predicting low birth weight. Additionally, the combination of uric acid, hemoglobin, and bilirubin levels appear to be optimal for predicting low birth weight in women with preeclampsia.