bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tubular GM-CSF Promotes Late MCP-1/CCR2-Mediated Fibrosis and Inflammation after Ischemia/Reperfusion Injury
Authors: Xu Leyuan , Sharkey Diana , Cantley Lloyd G. 
Published: July 2019

Significance Statement
Clinical evidence suggests that monocyte chemoattractant protein-1 (MCP-1) may be a useful biomarker to identify patients at risk for kidney fibrosis and CKD progression. Using a mouse model of unilateral ischemia/reperfusion injury (U-IRI), the authors show that sustained GM-CSF expression by renal tubular cells markedly increases Mcp-1 expression in macrophages during the transition from normal kidney repair to maladaptive fibrosis. Eliminating CCR2, the receptor of MCP-1, by using genetic engineering or a drug that blocks CCR2 decreases the accumulation and persistence of macrophages, dendritic cells, and T cells in the kidney, and reduces fibrosis and inflammation after a U-IRI. The results highlight the role of GM-CSF/MCP-1 signaling during the transition from AKI to CKD and suggest that therapeutic inhibition of MCP-1/CCR2 signaling may suppress kidney fibrosis.

Background
After bilateral kidney ischemia/reperfusion injury (IRI), monocytes infiltrate the kidney and differentiate into proinflammatory macrophages in response to the initial kidney damage, and then transition to a form that promotes kidney repair. In the setting of unilateral IRI (U-IRI), however, we have previously shown that macrophages persist beyond the time of repair and may promote fibrosis.

Methods
Macrophage homing/survival signals were determined at 14 days after injury in mice subjected to U-IRI and in vitro using coculture of macrophages and tubular cells. Mice genetically engineered to lack Ccr2 and wild-type mice were treated ±CCR2 antagonist RS102895 and subjected to U-IRI to quantify macrophage accumulation, kidney fibrosis, and inflammation 14 and 30 days after the injury.

Results
Failure to resolve tubular injury after U-IRI results in sustained expression of granulocyte-macrophage colony-stimulating factor by renal tubular cells, which directly stimulates expression of monocyte chemoattractant protein-1 (Mcp-1) by macrophages. Analysis of CD45+ immune cells isolated from wild-type kidneys 14 days after U-IRI reveals high-level expression of the MCP-1 receptor Ccr2. In mice lacking Ccr2 and wild-type mice treated with RS102895, the numbers of macrophages, dendritic cells, and T cell decreased following U-IRI, as did the expression of profibrotic growth factors and proimflammatory cytokines. This results in a reduction in extracellular matrix and kidney injury markers.

Conclusions
GM-CSF–induced MCP-1/CCR2 signaling plays an important role in the cross-talk between injured tubular cells and infiltrating immune cells and myofibroblasts, and promotes sustained inflammation and tubular injury with progressive interstitial fibrosis in the late stages of U-IRI.
A systematic decision support system to objectively evaluate retrospective energy efficiency modelling options
Authors: Botes L.A , Booysen W. , Mathews M.J. , Kleingeld M. 
Published: July 2019

Tax incentives are one of the methods used by the South African government to incentivise energy efficiency. One of these incentives is Section 12L of the Income Tax Act (1962), which allows a significant tax deduction as a result of quantifiable energy efficiency (EE) savings. The associated EE savings are calculated by means of baseline models and must be in accordance with the national standard for measurement and verification, i.e. SANS 50010, which is based on international practice. The present study developed a methodology that assists EE projects with incentive applications to objectively evaluate potential modelling options and ultimately select a final model. This methodology is based on the weighted sum method. It is verified by applying it to three actual case studies and is further validated by comparing the results obtained from the case studies to independent results of formal and successful incentive applications. The methodology allows for a transparent selection of a modelling option that is compliant with the relevant tax incentive regulatory requirements and untainted by personal bias.
Bir Üniversite Hastanesi Polikliniğine Başvuran Hastaların Sigara ve Alkol Bağımlılık Düzeylerine Etki Eden Faktörler
Authors: YAKAR Burkay , PİRİNÇÇİ Edibe 
Published: July 2019

Amaç:
Alkol ve sigara kullanımı toplum sağlığını tehdit eden önemli etkenlerin
başında gelmektedir. Sigara ve alkol ile mücadelenin önünde ki en büyük engel
ise bağımlılık yapıcı etkileri olarak gösterilmektedir. Çalışmamızda sigara ve
alkol bağımlılık düzeyleri ve etkileyen faktörleri araştırmak amaçlanmıştır.

Gereç ve Yöntem:
Kesitsel ve tanımlayıcı
nitelikteki bu çalışma, bir
üniversite hastanesinin aile hekimliği
polikliniğine başvuran katılımcılar üzerinde yapıldı. Veriler anket formu ile
toplandı. Çalışmaya gönüllü olarak katılmayı kabul eden 181 kişiye anket
uygulandı. Sigara kullanan 64 kişi ve alkol kullanan 28 kişi değerlendirmeye
alındı.

Bulgular:
Araştırmamızda sigara kullanım oranı
%35,4, alkol kullanım oranı %13,3 olarak bulundu. Erkek cinsiyet, erken başlama
yaşı ve kullanım süresinin uzaması hem sigara hem de alkol bağımlılık düzeyini
arttırdığı görüldü. Evlilerde ve eğitim düzeyi azaldıkça sigara bağımlılığı
artarken alkol bağımlılık düzeyinin bekarlarda ve eğitim seviyesi arttıkça
yükseldiği görüldü.

Sonuç:
Alkol ve sigara bağımlılığı halen önemli bir halk sağlığı sorunu olduğu ve mücadelede daha fazla etkin adımlar
atılmasının gerektiği saptanmıştır.
Transüretral Rezeksiyon- Prostat (TUR-P) Ameliyatlarında ERAS Protokolü İle Ameliyat Öncesi ve Sonrası Yapılması Gereken Beslenme, Ağrı ve Erken Mobilizasyon Uygulamalarının Karşılaştırılması
Authors: KANKILIÇ Rabia , TUNA Arzu 
Published: July 2019

Amaç: Yapılan
bu çalışmada TUR-P ameliyatları sonrası Avrupa'nın 5 ülkesinin bir araya
gelerek oluşturdukları ameliyat sonrası hızlı iyileşme (ASHİ) protokolünü Gaziantep’teki hastanelerde
bulunan sağlık personelinin duyup duymadığını; ağrı, erken
mobilizasyon ve beslenme konularının bakım ve tedavilerinde bu protokolün
gerekliliklerini uygulayıp uygulamadığını tespit etmek istedik.Gereç
ve Yöntem: Gaziantep'te bulunan beş hastanesinin
üroloji klinik hemşireleri, üroloji uzmanları ve anestezi uzmanlarına yönelik
demografik özellikler bulunduran soru formlarıyla, üroloji servisinde TUR-P
ameliyatı olan hastaların ASHİ protokolü ile ameliyat öncesi ve sonrası
yapılması gereken beslenme, ağrı ve erken mobilizasyon uygulamalarının
karşılaştırılması hakkındaki bilgiler belirlendi. Cerrahlara,
hemşirelere ve anestezi uzmanlarına bu konuları içeren anket soruları uygulandı
ve çalışmanın örneklemini 95 kişi oluşturdu. Araştırmacılar tarafından
hazırlanan ankette 25 soru bulunmaktaydı. Araştırma öncesi etik kuruldan, tüm
hastane ve katılımcılardan gerekli yasal izin alındı. Bu
veriler 1 Nisan 2018 -10 Haziran 2018
tarihleri arasında yüz yüze görüşülerek toplandı. Cerrahların, hemşirelerin ve
anestezi uzmanlarının ASHİ protokolüne göre bakım ve tedavilerindeki tutumları
analiz edildi; değerlendirmede sayı yüzde kullanıldı. Bulgular:
Sağlık personelinin yaş
ortalaması 34.73+ 9.11 idi, sağlık personelinin % 26,3’ü cerrah, % 17,9’u
anestezi uzmanı ve % 55,8’i hemşireydi. Hastalara ameliyatları öncesi, oral
olarak karbonhidrattan zengin sıvı verme durumu % 29,5 idi. “Ameliyat öncesi
açlık süresi ASHİ Protokolüne uygundur” diyenlerin oranı % 4,2 idi. Ameliyat
sonrası sıvı ve katı gıda alımı da ASHİ Protokolüne uygun değildi. Hastaların
bulantı ve kusmasını önlemek amacıyla profilaksi uygulanma durumu % 65,3’dü.
“TUR-P ameliyatı sonrası antiembolik çorap uyguluyoruz” diyenlerin oranı % 62.1
idi. Hastaları mobilize etme durumunda da ASHİ protokolüne uygun hareket
edilmiyordu. “Ameliyat sonrası ağrı için analjezik yapılmalı” diyenlerin oranı
% 62,1 iken antienflamatuar ilaç seçimi oranı ise % 44,2 idi. ASHİ protokolünü
duyanların oranı % 7,4’dü. ASHİ Protokolünü uygulayanların oranı ise %37,9’du.

Sonuç:
Yapılan bu çalışma sonucu ASHİ Protokolüne uygun bir bakım
ve tedavi prosedürünün TUR-P ameliyatlarından sonra uygulanmadığı söylenebilir.
Kanıta dayalı ASHİ protokolüne göre hemşirelik bakım paketlerinin ve tedavi
prosedürlerinin üroloji kliniklerinde uygulanmaya başlatılması için hizmet içi
eğitimlerin planlanması, tüm personelin ASHİ protokolüne benzeyen prosedürler
oluşturması ve araştırmalar yapması için komitelerin kurulması sağlanmalıdır.
A prospective, multi-institutional study of perioperative morbidities in the patients of renal cell carcinoma undergoing either open nephron sparing surgery or robotic nephron sparing surgery in fifty cases
Authors: Chandra Mahesh , Wasnik Seema , Karan Shailesh 
Published: July 2019

Background: Over the time, the nephron sparing surgery (NSS) has become ‘gold standard’ for treatment of T1a stage renal cell carcinoma (RCC) which saves precious renal tissue. We assessed and compared perioperative morbidities associated with open (ONSS) and robotic nephron sparing surgery (RNSS) in patients of T1a and T1b staged renal cell carcinoma.Methods: This prospective study was carried out from April 2016 to March 2018. A total of fifty (n=50) RCC patients underwent open or robotic nephron sparing surgery. The demographic data and perioperative morbidities associated with both methods of NSS were recorded and comparison of parameters including warm-ischemia time (WIT), hospital stay, perioperative bleeding, impact of renal-pedicle clamping was made in T1a and T1b staged RCC patients.Results: The most common perioperative morbidity was blood-loss and 12% patients had ≥500 ml loss. Significantly less intraoperative blood-loss was observed in RNSS compared to ONSS with decreased blood transfusion (BT), which decreased significantly after renal-pedicle clamping prior to RCC resection. Even In perioperative period, the blood loss was significantly less in RNSS patients. However, the warm ischemia time (WIT) and hospital stay was longer in patients of RNSS compared to ONSS. The WIT was prolonged in T1b compared to T1a lesions, irrespective NSS methods.Conclusions: Although, the most common perioperative morbidity associated with NSS is blood-loss but RNSS had less perioperative morbidities compared to ONSS. The blood loss decreased significantly during intraoperative period after renal-pedicle clamping which resulted into decreased blood transfusion after NSS by either method.
DOMESTIC VIOLENCE AS A CONSEQUENCE OF NUSYUZ UNDER THE ISLAMIC LAW AND LEGISLATION OF INDONESIA
Authors: Zuhdi Syaifuddin , . Kuswardani , Prakosa Andria Luhur , Kurnianingsih Marisa , Astuti Widi , Rahman Rozanah Ab. 
Published: July 2019

Purpose of the study: This paper aims to clarify the views of Islamic law on the acts of domestic violence as a consequence of nusyuz (disobedience) and its position under the legislation of Indonesia.
Methodology: This research was conducted by using the library research method. Documentary techniques are used in data collection, primary data is obtained from books, journals, and writings that directly discuss the material or problem under study, and from the secondary literature, which implicitly discusses it and is still quite relevant to be a comparison.
Main Findings: The findings of this discussion revealed that the legislation of Indonesia is very protective of women, which is in line with the Islamic law principle that prioritizes persuasive and not repressive efforts in overcoming conflicts in the household. The compilation of Islamic law does not regulate the beating of wife, but the rule contained in Law No. 23 of 2004 on the elimination of domestic violence prohibits violence in the household.
Applications of this study: This study can be useful for Indonesian people, especially for women and human right activists.
Novelty/Originality of this study: The novelty in this discussion is the enlightenment of the public about the existence of a relationship between Islamic law and applicable law in Indonesia, wherein Islamic law is often not considered to be in harmony with the law in existing discussions.
Narrating Human Rights in the Philippines
Authors: Abuso Ma. Rhea Gretchen Arevalo 
Published: July 2019

The 2016 national elections in the Philippines have been regarded as the most revealing and consequential democratic practice to the human rights situation in the country for two reasons. First, the overwhelming election of Rodrigo Duterte to the presidency was because of his campaign promise to rid the country of drugs and criminality within “3 to 6 months” through bloody and violent means. Second, the son and namesake of the late dictator Ferdinand Marcos, whose authoritarian regime in the 1970’s was responsible for countless human rights violations, narrowly lost his vice-presidential bid by a mere 270,000 votes. These turns of events beg the question: how could Filipinos, who experienced a bloody and violent regime at the hands of a dictator, choose to elect national leaders widely associated with human rights violations? This paper addresses this question through the use of in-depth interviews with Filipino college students in key cities in the Philippines in order to describe the Marcos regime from the perspective of the generation that did not experience the period. The research aimed to understand how memories of past human rights violations are formed and shaped, how these memories are crucial to the improvement of the human rights situation in society, and how to ensure that mistakes of the past are not repeated. The study found that widespread revisionist notions about the Marcos regime can be attributed to the absence of meaningful martial law and human rights education in the country. However, the study also found that young Filipinos regard the social institution of education as the most trustworthy bearer of information on human rights and violent regimes. This highlights the crucial role of schools and educators in promoting human rights in society.
KOMPARASI PERUBAHAN ASPEK SOSIAL EKONOMI PADA PENGHUNI RUMAH SUSUN PASCA PENANGANAN SQUATTER DI KOTA SURAKARTA
Authors: Kurniawan Khizam Deby , Hardiana Ana , Putri Rufia Andisetyana 
Published: July 2019

<p><em>City has main attraction for livable. The public has the view that a town has a comprehensive facilities , good accessibility , a broad field of work and so on. This matter causes population growth developments in the city, because people migrating to the city livelihood for the sake of more worthy. The increasing population is not balanced with the service especially in the field of housing the city settlement that will appear squatter. So that the squatter need to be handled, in general the handling of having two pattern handling squatter approach , that is a pattern on-site and off-site. On site pattern is a problem handling squatter location without move to another region but with providing a place of decent housing. While off site pattern is handling by moving the squatter to the regions and with the status of land was legal. In fact both handling is to improve social life and economic society. One of squatter handling in Surakarta is build a low cost apartment. The limited land in Surakarta is one of the reason to build a low cost apartment in the Surakarta City for handling squatter. Based on issues, this research knowing comparisons of socio-economic change in the low cost apartment post-handling squatter. The method is applicable in weighting analysis methods in identifying the social economy at low cost apartment in Surakarta. This result oh the research re the comparisons of socioeconomic aspects of changes on residents after handling squatter in Surakarta can be seen that in Begalon I low cost apartment experienced a medium increase, while in Begalon II low cost apartment and Semanggi low cost apartment increased low. So that the change in the economic and social aspect of Begalon I low cost apartment with on site pattern has the higher than Begalon II low cost apartment and Semanggi low cost apartment with off site pattern.</em></p><p><em> </em></p><p><strong><em>Keywords: </em></strong><em>low cost apartment, socioeconomic aspects, squatter</em></p>
KETERPADUAN KOMPONEN PENGEMBANGAN PARIWISATA KOTAGEDE SEBAGAI KAWASAN WISATA BUDAYA BERKELANJUTAN
Authors: Adhelia Nirmana , Soedwiwahjono Soedwiwahjono , Yudana Galing 
Published: July 2019

<p><em>Kotagede as the capital city of the former Mataram Islam kingdom has potential culture and history tourism which places in two different areas, Yogyakarta City and Bantul region. It needs contribution between Yogyakarta government, local government and local communities to protect Kotagede. The development of tourism activities also need support from all stakeholder to make the tourism sustain. Therefore, this research was conducted to determine the level of integration of tourism development components as the area of sustainable cultural tourism in Kotagede. The method of research is deductive-quantitative, while the data analisys technique used is descriptive analysis of quantitative, scoring and crosstab analysis. Results from this study is Kotagede judged to have met the criteria as a sustainable cultural tourism area with an integrated component of tourism development. However, when viewed from the stakeholder cooperation that occurred in the development of tourist areas, Kotagede showed a low value. Thus, although the components of tourism development Kotagede shows the alignment of sustainability, but the resulting relationship is still weak.</em></p><p><strong><em> </em></strong></p><p><strong><em>Keywords:</em></strong><em>cultural tourism area, integrated tourism, sustainable tourism, tourism</em></p>
Impact of Rotation During Installation on the Structural Performance of Slotted Liners in Thermally Stimulated Wells
Authors: Chartier Mark A. , Yung Victor Y. , Taubner Spencer P. 
Published: July 2019

Summary
Slotted liner is a sand–control technology used for completion of thermal wells. During installation, liners are subjected to tensile and compressive loads generated by string weight, wellbore drag, and bending when run through curved wellbores. Additionally, torque might be applied to “break” friction, when needed, to reduce axial drag and extend reach. These conditions lead to combined loading of liners with simultaneous axial, bending, and torsional loads.
Combined loading that exceeds the elastic capacity of the liner during installation can alter the structural capacity of the liner and reduce its ability to withstand subsequent operational loads. In particular, permanent deformation of liner struts during installation could create weak zones that trigger localization of deformations and liner failure under thermal–service loading conditions. Further, the presence of residual torque (from installation) can trigger and exacerbate the tendency of the liner struts to buckle.
Previously published works described slotted–liner installation limits and thermal operating limits separately. This paper examines the impact that rotation (during installation) can have on the subsequent thermal–service capacity and sand–control performance of a slotted liner. Specifically, the relationships between both plastic twist and residual torque from installation loads and the critical strain capacity and slot–width changes of a slotted liner under constrained thermal expansion were studied. Results demonstrated that a slotted liner can tolerate some plastic twist (during installation) without a significant impact on slot width or thermal–service performance. However, large amounts of plastic twist or residual torque from installation can bias the liner to fail in torsional buckling during thermal service. Slotted–liner tolerance, to both the plastic twist applied during installation and the residual torque remaining after installation, varies with liner configuration. Small amounts of plastic twist (0.5°/m) imposed on a high–density 60–slots–per–column (spc) liner resulted in a reduction in thermal–service capacity. In contrast, a low–density 35–spc liner with substantial imposed plastic twist (4°/m) demonstrated negligible changes in performance. Residual torque has a greater potential to impact liner performance, and its effect is less sensitive to the slotting density. Both the high–density 60–spc liner and the low–density 35–spc liner showed significant incremental slot–width changes during thermal service resulting from 5 kN·m of residual torque.
The findings of this work provided the basis for a proposed method to select appropriate engineering limits for the torque that can be applied safely to a slotted liner during running and for recommendations to reduce the potential for residual torque following installation.
Apparent Toughness Anisotropy Induced by “Roughness” of In-Situ Stress: A Mechanism That Hinders Vertical Growth of Hydraulic Fractures and Its Simplified Modeling
Authors: Fu Pengcheng , Huang Jixiang , Settgast Randolph R. , Morris Joseph P. , Ryerson Frederick J. 
Published: July 2019

Summary
The height growth of a hydraulic fracture is known to be affected by many factors that are related to the layered structure of sedimentary rocks. Although these factors are often used to qualitatively explain why hydraulic fractures usually have well–bounded height growth, most of them cannot be directly and quantitatively characterized for a given reservoir to enable a priori prediction of fracture–height growth. In this work, we study the role of the “roughness” of in–situ–stress profiles, in particular alternating low and high stress among rock layers, in determining the tendency of a hydraulic fracture to propagate horizontally vs. vertically. We found that a hydraulic fracture propagates horizontally in low–stress layers ahead of neighboring high–stress layers. Under such a configuration, a fracture–mechanics principle dictates that the net pressure required for horizontal growth of high–stress layers within the current fracture height is significantly lower than that required for additional vertical growth across rock layers. Without explicit consideration of the stress–roughness profile, the system behaves as if the rock is tougher against vertical propagation than it is against horizontal fracture propagation. We developed a simple relationship between the apparent differential rock toughness and characteristics of the stress roughness that induce equivalent overall fracture shapes. This relationship enables existing hydraulic–fracture models to represent the effects of rough in–situ stress on fracture growth without directly representing the fine–resolution rough–stress profiles.