bluuebunny/crossref_metadata_2025_split huggingface dataset:
KIAA1199 Biomarker and Ultrasonographic Findings in Rheumatoid
Arthritis Patients and their Correlation with Disease Activity
Authors: Selim Zahraa Ibrahim , El-Hakeim Eman H , Omran Eman Ahmed Hamed , Idriss Naglaa K. , Gaber Marwa A. , Ross Sylvia V 
Published: June 2018

Abstract
Introduction Rheumatoid arthritis (RA) is an autoimmune disease that
affects multiple joints causing joint destruction. KIAA1199 is a novel
angiogenic biomarker derived from fibroblast-like synoviocytes (FLS) it has a
role in acceleration and proliferation of FLS and activation of angiogenic
signaling pathways leading to erosion of cartilage and bone. Musculoskeletal
ultrasound (MUSU) and Power Doppler (PDUS) directly visualizing the synovial
membrane vessels, which is important in providing very early information on the
changes in synovitis activity during the course of the inflammatory joint
disease
Objective To assess the serum level of angiogenic biomarker KIAA1199 in
RA patients and its correlation with MSUS, PDUS findings, and the disease
activity Patients and methods: Fifty RA patients and 40 healthy control persons
age and sex-matched were recruited in this study, KIAA1199 was assessed in the
serum of patients and controls, MSUS and PDUS were done for the wrist, elbow,
and knee joints for all RA patients
Results Serum KIAA1199 level was significantly higher among RA patients
4.36±1.22 ng/dl compared to control group
2.87±0.51 ng/dl (p<0.001). There was a highly
significant correlation between KIAA1199 level and DAS28 (p=0.004), and
there was a significant correlation between the PDUS with KIAA1199 level and
DAS28 (p=0.001, 0.002 respectively) in wrist joints
Conclusion KIAA1199 is a new pathway that enhancing cell proliferation
and angiogenesis. Serum KIAA1199 level may be a useful biomarker for RA
activity, and therapeutic target in RA. PDUS correlates significantly with
clinical findings and novel angiogenic biomarker in RA patients.
Semiautomated System for Nonurgent, Clinically Significant Pathology Results
Authors: O'Connor Stacy , Khorasani Ramin , Pochebit Stephen , Lacson Ronilda , Andriole Katherine , Dalal Anuj 
Published: June 2018

Background Failure of timely test result follow-up has consequences including delayed diagnosis and treatment, added costs, and potential patient harm. Closed-loop communication is key to ensure clinically significant test results (CSTRs) are acknowledged and acted upon appropriately. A previous implementation of the Alert Notification of Critical Results (ANCR) system to facilitate closed-loop communication of imaging CSTRs yielded improved communication of critical radiology results and enhanced adherence to institutional CSTR policies.
Objective This article extends the ANCR application to pathology and evaluates its impact on closed-loop communication of new malignancies, a common and important type of pathology CSTR.
Materials and Methods This Institutional Review Board-approved study was performed at a 150-bed community, academically affiliated hospital. ANCR was adapted for pathology CSTRs. Natural language processing was used on 30,774 pathology reports 13 months pre- and 13 months postintervention, identifying 5,595 reports with malignancies. Electronic health records were reviewed for documented acknowledgment for a random sample of reports. Percent of reports with documented acknowledgment within 15 days assessed institutional policy adherence. Time to acknowledgment was compared pre- versus postintervention and postintervention with and without ANCR alerts. Pathologists were surveyed regarding ANCR use and satisfaction.
Results Acknowledgment within 15 days was documented for 98 of 107 (91.6%) pre- and 89 of 103 (86.4%) postintervention reports (p = 0.2294). Median time to acknowledgment was 7 days (interquartile range [IQR], 3, 11) preintervention and 6 days (IQR, 2, 10) postintervention (p = 0.5083). Postintervention, median time to acknowledgment was 2 days (IQR, 1, 6) for reports with ANCR alerts versus 6 days (IQR, 2.75, 9) for reports without alerts (p = 0.0351). ANCR alerts were sent on 15 of 103 (15%) postintervention reports. All pathologists reported that the ANCR system positively impacted their workflow; 75% (three-fourths) felt that the ANCR system improved efficiency of communicating CSTRs.
Conclusion ANCR expansion to facilitate closed-loop communication of pathology CSTRs was favorably perceived and associated with significant improved time to documented acknowledgment for new malignancies. The rate of adherence to institutional policy did not improve.
The Influence of Serotonin on Clot Retraction and the Thrombelastogram
Authors: Deutsch E , Martiny K 
Published: June 2018

Summary1. Normal platelets are necessary for induction of normal clot retraction.2. Serotonin does not induce retraction in human platelet-free plasma-clots or enhance clot firmness as measured in the coagulogram.3. Serotonin does not improve clot retraction or firmness in plasma clots with sub-optimal platelet counts.4. Methylserotonin inhibits clot retraction of platelet-rich plasma to a certain extent in moderate doses, whereas, high doses are ineffective. BOL 148 has a similar, but less significant action. There is a possibility that these effects are specific antiserotonin-effects.5. LSD 25 was ineffective in all concentrations used.6. Largactil and reserpin inhibit retraction in high doses. There seems to be a non specific effect caused by the high dose.7. Reserpine does not release a retraction-inducing agent from the platelets, which could be detected in the centrifuged platelet-free plasma used for the incubation.8. Serotonin does not replace the retraction-cofactor of Hartert, or the dialyzable factor of Lüscher in synthetic clotting substrates.9. Serotonin is of no essential value in inducing normal retraction of human plasma clots.
Perioperative Challenges in an Infant with Uncorrected “Pink-Tetralogy of Fallot”—for Excision of Choroid Plexus Papilloma: A Case Report
Authors: Pearl Julia , Lionel Karen Ruby , Mariappan Ramamani 
Published: June 2018

AbstractPerioperative management of an infant with intracranial tumor and congenital cyanotic heart disease poses a lot of challenges to the neuroanesthesiologist and neurointensivist. Maintaining both the cardiovascular and cerebrovascular homeostasis are of paramount importance for a successful outcome. In this case report, we have mentioned the perioperative challenges of a 7-month-old baby with tetralogy of Fallot who underwent craniotomy and excision of choroid plexus papilloma.
Modelling BioNano optical data and simulation study of genome map assembly
Authors: Chen Ping , Jing Xinyun , Ren Jian , Cao Han , Hao Pei , Li Xuan 
Published: June 2018

Abstract

Motivation
The launch of the BioNano next-generation mapping system has greatly enhanced the performance of physical map construction, thus rapidly expanding the application of optical mapping in genome research. Data biases have profound implications for downstream applications. However, very little is known about the properties and biases of BioNano data, and the very factors that contribute to whole-genome optical map assembly.

Results
We generated BioNano molecule data from eight organisms with diverse base compositions. We first characterized the properties/biases of BioNano molecule data, i.e. molecule length distribution, false labelling signal, variation of optical resolution and coverage distribution bias, and their inducing factors such as chimeric molecules, fragile sites and DNA molecule stretching. Second, we developed the BioNano Molecule SIMulator (BMSIM), a novel computer simulation program for optical data. BMSIM, is of great use for future genome mapping projects. Third, we evaluated the experimental variables that impact whole-genome optical map assembly. Specifically, the effects of coverage depth, molecule length, false-positive and false-negative labelling signals, chimeric molecules and nicking enzyme and nick site density were investigated. Our simulation study provides the empirical findings on how to control experimental variables and gauge analytical parameters to maximize benefit and minimize cost on whole-genome optical map assembly.

Availability and implementation
BMSIM is freely available on: https://github.com/pingchen09990102/BMSIM.

Supplementary information
Supplementary data are available at Bioinformatics online.
“Still a Cancer Patient”—Associations of Cancer Identity With Patient-Reported Outcomes and Health Care Use Among Cancer Survivors
Authors: Thong Melissa S Y , Wolschon Eva-Maria , Koch-Gallenkamp Lena , Waldmann Annika , Waldeyer-Sauerland Mechthild , Pritzkuleit Ron , Bertram Heike , Kajüter Hiltraud , Eberle Andrea , Holleczek Bernd , Zeissig Sylke R , Brenner Hermann , Arndt Volker 
Published: June 2018

Abstract

Background
The concept of cancer identity is gaining attention as more individuals are living with cancer as a chronic illness. Research is limited, and results suggest that a self-identity as “cancer patient” rather than a “cancer survivor” is associated with depression and lower health-related quality of life (HRQL). We aimed to identify factors associated with patient identity and investigate the associations between patient identity and treatment, health care use, psychosocial distress, and HRQL.

Methods
We used data from the population-based CAncEr Survivorship: A multi-Regional (CAESAR) study. Breast, colorectal, and prostate cancer survivors diagnosed during 1994–2004 completed a postal survey on patient identity, HRQL, psychological distress, and health care use in 2009–2011. We calculated odds ratios and the 95% confidence interval of having a patient identity. Analyses were adjusted for age, sex, education, and cancer stage, where appropriate.

Results
Of the 6057 respondents, colorectal cancer survivors (25%) were least likely to consider themselves patients, and prostate cancer survivors (36%) the most likely. Being male, younger age, comorbidity, higher cancer stage, and disease recurrence were associated with patient identity. Treatment was associated with patient identity, except among female colorectal cancer survivors. Having a patient identity was associated with higher health care use within the past 12 months. Survivors who still consider themselves patients were more likely to be depressed and reported significantly lower HRQL.

Conclusions
A significant proportion of cancer survivors still consider themselves patients five to 15 years postdiagnosis. Sensitivity to individuals’ self-identity should be considered when exploring their cancer experience.
Political Reform in Israel
Authors: Rahat Gideon 
Published: June 2018

Abstract
Israel has experienced both failed and successful attempts to reform its democratic institutions in the seventy years since its founding. The most noteworthy failure has been in the promotion of much-needed electoral reform that would moderate the “extreme” features of the hyper-representative, party-centered electoral system. Successes range from small modifications of the electoral system to wide-ranging reforms of the government system at the local and national levels and within political parties. These reforms injected doses of majoritarianism and personalism into the system. But they did not help to solve the problems in the functioning of the Israeli regime; in fact, they often made them worse.
State and Society Building in Early Israel
Authors: Rozin Orit 
Published: June 2018

Abstract
This chapter portrays the political and legal regime of Israel in its early years as the product of three factors: the conscious political effort of the Zionist movement; a nation-building process, which was a vast cultural endeavour aimed at constructing a new sovereign Jew; and decolonization in a territory where the British legacy still had significant political and legal influence. The chapter argues that notwithstanding its dependence on great powers and the Jewish Diaspora, and despite its weakness on the international stage, Israel displayed a not insignificant measure of political independence. On the level of intra-Jewish consciousness, the achievement was even greater. Diaspora Jews saw the establishment of the state as a transformative moment in Jewish history; its Jewish citizens felt that they were achieving political liberty.
Interest in Getting Help to Reduce or Stop Substance Use Among Syringe Exchange Clients Who Use Opioids
Authors: Frost Madeline C. , Williams Emily C. , Kingston Susan , Banta-Green Caleb J. 
Published: June 2018

Objectives:Opioid use is a growing problem in the United States. Despite existence of effective treatments (eg, opioid agonist medication), most people with opioid use disorder do not receive treatment. Increasing treatment receipt is an essential component of the response to the opioid crisis. We examined factors associated with interest in getting help to reduce or stop substance use among syringe exchange program (SEP) clients who reported using opioids.Methods:Surveys were administered at 17 SEPs across Washington State during 2015; 436 respondents who reported recent opioid use and not receiving current treatment were eligible for this analysis. Multivariable logistic regression was conducted to examine factors associated with being somewhat or very interested in getting help, including sociodemographic characteristics, substance use behaviors and outcomes, and use of health care services.Results:Most participants reported interest in getting help (77.5%). Factors positively associated with interest included female gender (adjusted odds ratio [AOR] = 1.79; 95% confidence interval [CI]: 1.03, 3.11), having an abscess (AOR = 1.87; 95% CI: 1.02, 3.40), and having received treatment (AOR = 4.83; 95% CI: 1.77, 13.14) or other services (AOR = 3.01; 95% CI: 1.06, 8.54) in the past year. Recent methamphetamine use was negatively associated with interest in getting help (AOR = 0.49; 95% CI: 0.26, 0.91).Conclusions:In this survey of SEP clients, interest in getting help to reduce or stop substance use was prevalent and varied across subpopulations of persons using opioids. Findings point to SEPs as an important venue for treatment engagement, and suggest subgroups who may be targeted for engagement interventions.
Evaluation of an Ion Trap Toxtyper Liquid Chromatography With An Ion Trap Mass Spectrometric Instrument (Toxtyper) for Drug of Abuse Screening in Oral Fluid
Authors: Plecko Thomas , Berbalk Kevin , Wieland Eberhard , Shipkova Maria 
Published: June 2018

Background:Oral fluid (OF) is increasingly used as an alternative sample matrix in drug of abuse screening. Screening is commonly performed by immunoassays and results confirmed using laborious gas chromatography–mass spectrometry (GC-MS)–based methods. Therefore, an easy to operate ion trap mass spectrometric (IT-MS) commercial screening method (Toxtyper; Bruker Daltronik, Bremen, Germany) combined with a laboratory-developed sample preparation procedure has been evaluated for their application to OF.Methods:OF samples were subjected to protein precipitation followed by HybridSPE-Phospholipid extraction. Chromatographic separation was achieved by ultra–high-performance liquid chromatography; MS2/MS3 spectra were recorded by IT-MS and analyzed using a library provided by the manufacturer (Bruker Daltronik). The lower limit of detection, linearity, imprecision, inaccuracy, and specificity (interferences and matrix effects) were investigated for methadone, buprenorphine, pregabalin, fentanyl, amphetamine, 3,4-methylendioxy-N-methylamphetamine, cocaine, acetylcodeine, and nordiazepam, after spiking drug-free OF with these test substances. In addition, concordance between IT-MS results and gas chromatography–tandem mass spectrometry, liquid chromatography–tandem mass spectrometry, or immunoassay (buprenorphine) results was investigated.Results:No interferences or matrix effects were observed. The lower limit of detection for acetylcodeine, amphetamine, benzoylecgonine, methadone, and nordiazepam was below the common cutoffs for immunological screening assays and comparable to that of GC-MS. Imprecision and inaccuracy, both in- and between-series, were consistently <25%, except for buprenorphine. Toxtyper screening for pregabalin and fentanyl was less sensitive than a targeted liquid chromatography–tandem mass spectrometry assay. A very good concordance was found between the previous analytical approach and the new IT-MS method.Conclusions:The Toxtyper IT-MS is easy to use and can be applied for the screening of drug of abuse and the qualitative confirmation analysis in OF in a clinical toxicology service. Although intended for qualitative analysis, performance data suggest that the methods investigated may also be applicable for semiquantitative longitudinal follow-up.
Toxoplasmosis in the non-orthotopic heart transplant recipient population, how common is it? Any indication for prophylaxis?
Authors: Dhakal Reshika , Gajurel Kiran , Montoya Jose G. 
Published: June 2018

Purpose of review
Unlike in orthotopic heart transplant (OHT) setting where toxoplasma prophylaxis is a standard practice in pretransplant toxoplasma seronegative recipients who have received donor hearts from seropositive donors (D+/R-), there is no consensus regarding prophylaxis in non-OHT recipients.

Recent findings
The incidence of toxoplasma disease in non-OHT recipients is less than 1% but its true burden is underestimated. Among 31 cases of toxoplasma disease reported from 2004 through 2017, renal and liver transplant recipients comprised of 90% of cases. A total of 94% of 18 recipients with known pretransplant serology were seronegative recipients (mostly D+/R-). Out of 16 recipients with adequate information, 10 (63%) and five (31%) were deemed to be donor derived and nondonor-derived primary toxoplasmosis respectively. Tissue invasive reactivation was uncommon. Almost all cases were described in patients not on prophylaxis at the time of presentation. Universal screening of donor/recipient toxoplasma serology for risk stratification is beneficial as illustrated by reports of fatal cases of toxoplasmosis due to unavailability of positive donor serology results.

Summary
Toxoplasma disease in non-OHT predominantly occurs in pretransplant seronegative recipients- mostly in D+/R- group and is rare in seropositive recipients. Posttransplant prophylaxis should be targeted against the high-risk D+/R- group and should be considered in seropositive recipients in whom unusually high immunosuppression is implemented. Toxoplasma serologies and PCR should be used in combination for the diagnosis of toxoplasmosis in non-OHT patients.
Nitroglycerin Ointment for Reducing the Rate of Mastectomy Flap Necrosis in Immediate Implant-Based Breast Reconstruction
Authors: Turin Sergey Y. , Li Daniel D. , Vaca Elbert E. , Fine Neil 
Published: June 2018

Background:
Mastectomy flap necrosis remains a challenging complication in immediate tissue expander breast reconstruction. Nitroglycerin ointment has been shown to reduce the incidence of mastectomy flap necrosis in a randomized controlled study, using 45 g per breast and treating one side only in bilateral cases. This study was conducted to determine the efficacy of 15 g of nitroglycerin ointment per breast, therefore permitting application to both breasts in cases of bilateral mastectomy.

Methods:
A retrospective cohort study of patients undergoing immediate tissue expander breast reconstruction performed by a single reconstructive surgeon was conducted. The intervention cohort consisted of all patients between June 10, 2015, and June 9, 2016 (94 patients, 158 breasts), where 15 g of nitroglycerin ointment was routinely applied per breast. The control cohort consisted of all patients from June 10, 2014, to June 9, 2015 (107 patients, 170 breasts), where nitroglycerin was not applied. All complications were tracked, including minor wound healing problems.

Results:
There was an overall 22 percent decreased incidence of mastectomy flap necrosis in the nitroglycerin ointment cohort (47.5 percent versus 60.6 percent; p = 0.002), with a 44 percent reduction in full-thickness mastectomy flap necrosis that trended toward statistical significance (9.5 percent versus 16.5 percent; p = 0.06). On multivariate analysis, nitroglycerin application was independently associated with a decrease in mastectomy flap necrosis or need for mastectomy flap débridement. There was no significant difference in the incidence of postoperative hypotension (3.8 percent versus 2.9 percent) or headache among cohorts.

Conclusion:
Topical nitroglycerin ointment application to mastectomy skin flaps at 15 g per breast is a cost-effective means of decreasing the incidence of mastectomy flap necrosis in unilateral and bilateral immediate tissue expander breast reconstruction.

CLINICAL QUESTION/LEVEL OF EVIDENCE:
Therapeutic, III.
Crossover to Bilateral Repetitive Transcranial Magnetic Stimulation
Authors: Cristancho Pilar , Trapp Nicholas T. , Siddiqi Shan H. , Dixon David , Miller J. Philip , Lenze Eric J. 
Published: June 2018

Abstract
Clinical trials using left-sided repetitive transcranial magnetic stimulation (rTMS) report remission rates of 14% to 32.6%. A large percentage of patients would not achieve remission with standard rTMS treatment. The question of what clinicians should do when a patient is not responding to standard high-frequency (HF) left-sided rTMS remains unanswered. This prospective case series examines whether crossover to bilateral stimulation enhances antidepressant outcomes in patients not responding to unilateral rTMS. Patients in a major depressive episode received an rTMS clinical protocol of 4 to 6 weeks' duration. Stimulation began with HF rTMS (10 Hz) over the left dorsolateral prefrontal cortex (range, 3000–5000 pulses per session). A total of 17 patients without sufficient clinical improvement early in their rTMS course received 1-Hz rTMS (range, 600–1200 pps) over the right dorsolateral prefrontal cortex (added to the HF left-sided stimulation). Hamilton Depression Rating Scale scores decreased from 13.9 ± 3.9 (mean ± SD) from the start of augmentation to 12.2 ± 5.8 at the end of acute treatment, a 1.7-point change, Cohen d effect size = −0.35, 95% confidence interval, −1.01 to − 0.34, suggesting improvement. Remission rate in this sample was 24% (4/17). This case series indicates that crossover to bilateral stimulation is a feasible and potentially effective strategy when patients are not improving with standard rTMS. A randomized controlled trial comparing crossover versus standard rTMS is needed to determine the efficacy of this paradigm.
Mesolimbic dopamine projections mediate cue-motivated reward seeking but not reward retrieval
Authors: Halbout Briac , Marshall Andrew T. , Azimi Ali , Liljeholm Mimi , Mahler Stephen V. , Wassum Kate M. , Ostlund Sean B. 
Published: June 2018

AbstractEfficient foraging requires an ability to coordinate discrete reward-seeking and reward-retrieval behaviors. We used pathway-specific chemogenetic inhibition to investigate how mesolimbic and mesocortical dopamine circuits contribute to the expression and modulation of reward seeking and retrieval. Inhibiting ventral tegmental area dopamine neurons disrupted the tendency for reward-paired cues to motivate reward seeking, but spared their ability to increase attempts to retrieve reward. Similar effects were produced by inhibiting dopamine inputs to nucleus accumbens, but not medial prefrontal cortex. Inhibiting dopamine neurons spared the suppressive effect of reward devaluation on reward seeking, an assay of goal-directed behavior. Attempts to retrieve reward persisted after devaluation, indicating they were habitually performed as part of a fixed action sequence. Our findings show that complete bouts of reward seeking and retrieval are behaviorally and neurally dissociable from bouts of reward seeking without retrieval. This dichotomy may prove useful for uncovering mechanisms of maladaptive behavior.