bluuebunny/crossref_metadata_2025_split huggingface dataset:
Seizure‐induced microvascular injury is associated with impaired neurovascular coupling and blood–brain barrier dysfunction
Authors: Prager Ofer , Kamintsky Lyna , Hasam‐Henderson Luisa A. , Schoknecht Karl , Wuntke Vera , Papageorgiou Ismini , Swolinsky Jutta , Muoio Valeria , Bar‐Klein Guy , Vazana Udi , Heinemann Uwe , Friedman Alon , Kovács Richard 
Published: January 2019

SummaryObjectiveBlood–brain barrier (BBB) impairment, redistribution of pericytes, and disturbances in cerebral blood flow may contribute to the increased seizure propensity and neurological comorbidities associated with epilepsy. However, despite the growing evidence of postictal disturbances in microcirculation, it is not known how recurrent seizures influence pericytic membrane currents and subsequent vasodilation.MethodsHere, we investigated successive changes in capillary neurovascular coupling and BBB integrity during recurrent seizures induced by 4‐aminopyridine or low‐Mg2+ conditions. To avoid the influence of arteriolar dilation and cerebral blood flow changes on the capillary response, we measured seizure‐associated pericytic membrane currents, capillary motility, and permeability changes in a brain slice preparation. Arteriolar responses to 4‐aminopyridine–induced seizures were further studied in anesthetized Sprague Dawley rats by using electrocorticography and tissue oxygen recordings simultaneously with intravital imaging of arteriolar diameter, BBB permeability, and cellular damage.ResultsWithin the preserved vascular network in hippocampal slice cultures, pericytes regulated capillary diameter in response to vasoactive agents and neuronal activity. Seizures induced distinct patterns of membrane currents that contributed to the regulation of pericytic length. During the course of recurrent seizures, individual vasodilation responses eroded and BBB permeability increased, despite unaltered neurometabolic coupling. Reduced vascular responsiveness was associated with mitochondrial depolarization in pericytes. Subsequent capillary constriction preceded BBB opening, suggesting that pericyte injury mediates the breach in capillary integrity. In vivo findings were consistent with slice experiments, showing seizure‐related neurovascular decoupling and BBB dysfunction in small cortical arterioles, accompanied by perivascular cellular injury despite normoxic conditions.SignificanceOur study presents a direct observation of gradually developing neurovascular decoupling during recurrent seizures and suggests pericytic injury as an inducer of vascular dysfunction in epilepsy.
Strontium plesiotherapy for the treatment of sarcoids in the horse
Authors: Hollis A. R. 
Published: January 2019

SummarySarcoids are a common condition in the horse. They are often difficult to treat and there is no universally effective treatment method. Radiotherapy is the most consistently successful treatment and plesiotherapy may be effective for carefully selected sarcoid lesions. The objective of this retrospective clinical case series was to describe the response rate and safety of strontium plesiotherapy for the treatment of equine sarcoids. Horses and ponies referred for strontium treatment of sarcoids were eligible for inclusion in the study and diagnosis was based solely on the clinical features. Horses were given a total tumour dose of 100 Gy under either standing sedation or general anaesthesia, depending on the accessibility of the lesion. Eight horses with 10 sarcoids were treated with strontium plesiotherapy. Follow‐up was available for between 6 and 30 months after treatment. Complete resolution occurred in all cases. No significant short or long‐term adverse effects were noted apart from local leucotrichia, leukoderma and hair loss. The major limitations of this study are the lack of long‐term follow‐up and the small number of horses. It was concluded that strontium plesiotherapy appears to be an effective and safe method of treating selected equine sarcoids. This is a useful alternative for lesions in areas difficult to treat with other methods or where other methods have been unsuccessful. Longer term follow‐up is required to determine the risk of recurrence of treated lesions.
Potential trade‐offs of employing perennial biomass crops for the bioeconomy in the EU by 2050: Impacts on agricultural markets in the EU and the world
Authors: Choi Hyung Sik , Grethe Harald , Entenmann Steffen K. , Wiesmeth Michael , Blesl Markus , Wagner Moritz 
Published: January 2019

AbstractPerennial biomass crops (PBC) are considered a crucial feedstock for sustainable biomass supply to the bioeconomy that compete less with food production compared to traditional crops. However, large‐scale development of PBC as a means to reach greenhouse gas (GHG) mitigation targets would require not only the production on land previously not used for agriculture, but also the use of land that is currently used for agricultural production. This study aims to evaluate agricultural market impacts with biomass demand for food, feed, and PBC in four bioeconomy scenarios (“Business as usual,” “Improved relevance of bioeconomy,” “Extensive transformation to a bioeconomy,” “Extensive transformation to a bioeconomy with diet change”) to achieve a 75% GHG reduction target in the emission trading sector of the EU until 2050. We simulated bioeconomy scenarios in the energy system model TIMES‐PanEU and the agricultural sector model ESIM and conducted a sensitivity analysis considering crop yields, PBC yields, and land use options of PBC. Our results show that all bioeconomy scenarios except the one with diet change lead to increasing food prices (the average food price index increases by about 11% in the EU and 2.5%–3.0% in world markets). A combination of the transformation to a bioeconomy combined with diet change toward less animal protein in the EU is the only scenario that results in only moderately increasing food prices within the EU (+3.0%) and even falling global food prices (–6.4%). In addition, crop yield improvement and cultivation of PBC on marginal land help to reduce increases in food prices, but higher land prices are inevitable because those measures have only small effects on sparing agricultural land for PBC. For a transition to a bioeconomy that acknowledges climate mitigation targets, counter‐measures for those substantial direct and indirect impacts on agricultural markets should be taken into account.
Detailed pathological analysis of the advancing edge of the tumour can effectively stratify clinical T4b colorectal cancer patients
Authors: Kim So‐Woon , Kim Jiyoon , Hong Seung‐Mo , Yoon Yong Sik , Park In Ja , Yu Chang Sik , Kim Jihun 
Published: January 2019

AbstractAimsPathological staging of colorectal cancers (CRCs) that involve adhesion to adjacent organs (clinical stages T4b, cT4b) is sometimes difficult because the morphology of the invasive front varies. To resolve this issue, we reviewed 492 surgically resected CRC samples, comprising 96 cT4b tumours and, for comparison, 335 typical pathological stages (p) T3 and 61 pT4a tumours.Methods and resultsCases were subdivided into four groups according to the presence or absence of microscopic tumour invasion into the muscular wall of the adjacent organs and peritumoral abscess along invasive front. Those that directly invaded the wall of the adjacent organs without peritumoral abscess were associated with a significantly worse overall (OS) and recurrence‐free survival (RFS) than the other three types of cT4b tumours. Those with peritumoral abscess showed similar prognosis to typical pT3 tumours, even when the advancing edge of the tumour invaded the wall of adjacent organs (staged as pT4b). Tumours showing fibrous adhesions without tumour cell invasion into the muscular wall of the adjacent organs showed a similar prognosis to typical pT3 tumours and showed a better prognosis than pT4a tumours.ConclusionOnly CRCs with tumour cell invasion into the muscular wall of the adjacent organs should be classified as pT4b, and it might be better to avoid ‘the presence of tumour cells in fibrous adhesion' to define pathological T4b CRCs. In addition, the presence of a peritumoral abscess should be recorded as a predictor of better prognosis.
An investigation into green coffee press cake as a renewable source of bioactive compounds
Authors: Resende Oliveira Érica , Fonseca da Silva Rodrigo , Ribeiro Santos Paula , Queiroz Fabiana 
Published: January 2019

SummaryThe residual biomass of coffee, obtained after the oil extraction from coffee beans, called coffee beans residual press cake, has been attracted interest as a source of compounds with antioxidant capacity. This study investigated the effects of ethanolic and methanol‐acetone extracts of green coffee beans (GCB) and its residual press cake (GCC) on the phenolic composition and antioxidant capacity. Antioxidant capacity was assayed through five different methods (total phenolic compounds, •DPPH, ABTS, FRAP and β‐carotene bleaching assay), and the phenolic profile of the samples through High Performance Liquid Cromatography. GCB and GCC enclosed chlorogenic (55.16 and 64.96 mg g−1, respectively) and caffeic (25.07 and 44.37 mg g−1, respectively) acids as the major components, and the cake presented higher antioxidant capacity than the actual green bean. Antioxidant capacity was higher for GCC extracted with methanol and acetone. This study on the evaluation of the effects of the type of solvent on the bioactive compounds from GCB and GCC showed that this by‐product can be a source of new value‐added products, such as phenolic antioxidant adjuncts for food or pharmaceutic processing.
‘You don't know what you don't know’: The essential role of management exposure, understanding and commitment in peer workforce development
Authors: Byrne Louise , Roennfeldt Helena , Wang Ying , O'Shea Peri 
Published: January 2019

AbstractThe peer workforce has increased significantly in recent years; however, structured development and support for the roles are lacking. This paper explores the role of executive and senior management understanding in the employment of peer roles. In‐depth, semi‐structured interviews and one focus group were conducted with 29 participants from a range of nongovernment and public mental health services within Queensland, Australia. Findings of this study suggest management exposure to and understanding of peer work are essential to the development of an effective peer workforce. Exposure and understanding of peer roles reportedly led to greater acceptance and commitment from management. This commitment inspired action in the form of; enhanced support including advocacy/championing, increased development of roles and influenced culture within the organization to be more accepting of peer work. There was a perception that developing an ‘accepting’ organizational culture supported the integrity and expansion of peer roles including designated ‘peer management’ positions. Development of peer management positions is suggested as an effective means of improving the impact of peer perspectives, advocating for peer work and providing ongoing and timely supervision. Recommendations include the need for training and information for management on the unique function, purpose and value of peer roles; and the development of networks, including mentoring opportunities, for organizations with limited experience to gain support and advice from those with greater experience developing peer roles.
Validation of a wrist‐type home nocturnal blood pressure monitor in the sitting and supine position according to the ANSI/AAMI/ISO81060‐2:2013 guidelines: Omron HEM‐9600T
Authors: Kuwabara Mitsuo , Harada Kanako , Hishiki Yukiko , Kario Kazuomi 
Published: January 2019

AbstractThe purpose of the present study was to evaluate the performance of the Omron HEM‐9600T, an automatic wrist‐type device for self BP measurement, in the sitting position with the wrist at heart level and supine position according to the ANSI/AAMI/ISO81060‐2:2013 guidelines. In the supine position, we evaluated the device under 3 different conditions: using the supine with sideways palm position, the supine with upwards palm position, and the supine with downwards palm position. After 106 subjects were screened and 21 subjects were excluded, the same 85 subjects (38 men [44.7%] and 47 women [55.3%]) were included in the analyses for each position. The average age of the subjects was 54.5 ± 12.2 years (mean ± SD). The mean wrist circumference was 17.0 ± 2.4 cm. The wrist size distribution fulfilled the requirements of the guidelines. The mean differences between reference BPs and HEM‐9600T readings were 1.0 ± 6.7/1.4 ± 5.7 mm Hg, 6.6 ± 7.2/5.5 ± 6.0 mm Hg, 4.8 ± 7.2/4.9 ± 5.8 mm Hg, and 2.1 ± 7.2/2.8 ± 6.8 mm Hg for SBP/DBP in the sitting position, supine with sideways palm position, supine with upwards palm position, and supine with downwards palm position, respectively. In conclusion, the Omron HEM‐9600T in the sitting position fulfilled the validation criteria of the ANSI/AAMI/ISO81060‐2:2013 guidelines. On the other hand, the accuracies of HEM‐9600T in the supine position differed depending on the positioning of the palm, with only the downwards palm‐position measurement fulfilling both validation criteria of the ANSI/AAMI/ISO81060‐2:2013 guidelines.
Oestrogen‐related receptor alpha mediates chemotherapy resistance of osteosarcoma cells via regulation of ABCB1
Authors: Chen Yantao , Zhang Kunshui , Li Yang , Guo Ruilian , Zhang Kelin , Zhong Guifang , He Qing 
Published: January 2019

AbstractChemotherapy resistance is one of the major challenges for the treatment of osteosarcoma (OS). The potential roles of oestrogenic signals in the chemoresistance of OS cells were investigated. As compare to the parental cells, the doxorubicin and cisplatin (CDDP) resistant OS cells had greater levels of oestrogen‐related receptors alpha (ERRα). Targeted inhibition of ERRα by its specific siRNAs or inverse agonist XCT‐790 can restore the sensitivity of OS resistant cells to chemotherapy. This might be due to that si‐ERRα can decrease the expression of P‐glycoprotein (P‐gp, encoded by ABCB1), one important ABC membrane transporter for drug efflux. XCT‐790 can decrease the transcription and mRNA stability of ABCB1, while had no effect on protein stability of P‐gp. ERRα can bind to the transcription factor of SP3 to increase the transcription of ABCB1. Furthermore, XCT‐790 treatment decreased the expression of miR‐9, which can bind to the 3′UTR of ABCB1 and trigger its decay. Collectively, we found that ERRα can regulate the chemoresistance of OS cells via regulating the transcription and mRNA stability of ABCB1. Targeted inhibition of ERRα might be a potential approach for OS therapy.
Alantolactone promotes ER stress‐mediated apoptosis by inhibition of TrxR1 in triple‐negative breast cancer cell lines and in a mouse model
Authors: Yin Changtian , Dai Xuanxuan , Huang Xiangjie , Zhu Wangyu , Chen Xi , Zhou Qiulin , Wang Canwei , Zhao Chengguang , Zou Peng , Liang Guang , Rajamanickam Vinothkumar , Wang Ouchen , Zhang Xiaohua , Cui Ri 
Published: January 2019

AbstractTriple‐negative breast cancer (TNBC) is a subtype of breast cancer with poor clinical outcome and currently no effective targeted therapies are available. Alantolactone (ATL), a sesquiterpene lactone, has been shown to have potential anti‐tumour activity against various cancer cells. However, the underlying mechanism and therapeutic effect of ATL in the TNBC are largely unknown. In the present study, we found that ATL suppresses TNBC cell viability by reactive oxygen species (ROS) accumulation and subsequent ROS‐dependent endoplasmic reticulum (ER) stress both in vitro and in vivo. Thioredoxin reductase 1 (TrxR1) expression and activity of were significantly up‐regulated in the TNBC tissue specimens compare to the normal adjacent tissues. Further analyses showed that ATL inhibits the activity of TrxR1 both in vitro and in vivo in TNBC and knockdown of TrxR1 in TNBC cells sensitized ATL‐induced cell apoptosis and ROS increase. These results will provide pre‐clinical evidences that ATL could be a potential therapeutic agent against TNBC by promoting ROS‐ER stress‐mediated apoptosis through partly targeting TrxR1.
Efficacy of photoactivated curcumin to decontaminate food surfaces under blue light emitting diode
Authors: Aurum Fawzan Sigma , Nguyen Loc Thai 
Published: January 2019

AbstractThe efficacy of photoactivated curcumin in decontaminating food surfaces using a 465 nm light emitting diode (LED) light source was investigated. Under studied conditions, LED illumination alone had negligible antibacterial effects while photoactivated curcumin exhibited strong bactericidal activities against Escherichia coli. Minimum inhibitory concentration of photosensitized curcumin against E. coli on nutrient agar surface at a concentration of 1.5 × 105 cfu/cm2 was estimated to be 1.60 × 10−3 M, combined with irradiation of 27.2 J/cm2 at 465 nm. Bacterial inactivation kinetics could be described by a Weibull model (R2 = 0.979–0.999, RMSE = 0.019–0.229). When the treatment was applied on grape surface, the efficiency was lower as compared to that on the agar surface. Photoactivation enhanced quality retention of the samples during storage with significant preservation of vitamin C, color, texture, and reduction of weight losses.Practical applicationsThe study provides an alternative method for food surface decontamination. Inactivation of pathogens and spoilage microorganism by combined visible LED light source and natural photosensitizers minimizes the adverse processing effects on organoleptic and physicochemical quality of the treated foods. The approach could be further optimized, scaled up, and applied in food industries.
Adverse drug event‐related hospitalisation in persons with neurodevelopmental disorders: a state‐wide retrospective cohort study
Authors: Zhou M. , Du W. , Salvador‐Carulla L. , Glasgow N. 
Published: January 2019

AbstractBackgroundLittle is known about the sociodemographic and clinical characteristics of adverse drug events (ADEs) in patients with neurodevelopmental disorders (NDD).ObjectiveThe objective of this study was to describe and compare the demographic details of people with and without NDD hospitalised due to ADEs.MethodsThe all‐inclusive New South Wales Admitted Patient Data Collection from 2001 to 2014 was employed to identify ADE‐related hospitalisations in patients with NDD using the International Classification of Diseases 10th revision Australian modification codes. We derived case sets specific to different clinical groups and patient characteristics and compared proportional differences between patients with and without intellectual disability using chi squared tests.ResultsA total of 2173 patients with NDD were admitted for acute care of ADEs, accounting for 0.7% of all ADE‐related hospitalisations. Hospitalised ADEs among patients with NDD increased by twofold over the 14‐year study period. Psychotropic medications and opioid analgesic medications were leading causes of ADE‐related hospitalisations in patients with NDD. Compared with their counterparts, patients with NDD were younger, experienced more socio‐economic disadvantage and less private insurance coverage, suffered with less severe but different co‐morbid clinical conditions and incurred more challenges in the acute hospital care setting.ConclusionAlthough the pattern of ADE‐related hospitalisations in patients with NDD differed from that in patients without NDD, there is a lack of targeted healthcare programmes to meet their special needs. This study suggests the need for countermeasures in primary healthcare settings to reduce the burden of ADEs in this vulnerable group.
Alimentary Dignity: Defining a Decent Meal in Post‐Soviet Cuban Household Cooking
Authors: Garth Hanna 
Published: January 2019

ResumenA medida que el sistema alimentario cubano contemporáneo cambia, los consumidores domésticos necesitan ajustar sus hábitos diarios de consumo alimentario. En este artículo demuestro las maneras en que los consumidores cubanos usan la categoría de la “comida decente” para mantener los límites de los alimentos “reales”. Introduzco la “dignidad alimentaria” como una estructura para entender por qué los cubanos consideran ciertas prácticas de consumo decentes, llamando a otros “no reales”. La noción de dignidad alimentaria es una forma de dar un significado social a nuevas formas de consumo mientras la disponibilidad de los alimentos cambia con cambios socioeconómicos en Cuba. La categorización de sus comidas en esta manera es una forma de afecto mediado que esta profundamente enredado con deseos de vivir de manera idealizada. Los conceptos de dignidad alimentaria y la comida decente contribuyen a una comprensión más amplia de cómo las personas hacen el significado de las circunstancias cambiantes de la vida. [comida, Cuba, globalizacion, identidad, mercados, nutricion]
Psychiatric Disorders After Attention‐Deficit/Hyperactivity Disorder: A Nationwide Population‐Based Study in Taiwan
Authors: Huang Ya‐Fang , Chiou Hung‐Yi , Chung Chi‐Hsiang , Chien Wu‐Chien , Chang Hsiu‐Ju 
Published: January 2019

AbstractPurposeTo investigate the risk for psychiatric disorders in patients newly diagnosed with attention deficit hyperactive disorder (ADHD) from two longitudinal groups of children with and without ADHD.Study DesignIn total, 1,745 children newly diagnosed with ADHD and 6,980 participants without ADHD were identified from Taiwan's National Health Insurance Research Database in 2005 and followed until 2010. Risks for psychiatric disorders in the ADHD and non‐ADHD groups were compared.ResultsThe ADHD group was 3.82 times more likely to develop psychiatric disorders than their counterparts. The ADHD group showed the highest risk for oppositional defiant disorder, followed by adult ADHD and autism spectrum disorder. Moreover, the time effects of psychiatric disorders in the ADHD group were significant. Patients with ADHD subtypes had a significant risk for psychiatric disorders compared to their counterparts.ConclusionsA high risk for psychiatric disorders was revealed in this study among children with ADHD. Childhood ADHD, the duration after the ADHD diagnosis, and the ADHD subtype were associated with psychiatric disorders.Clinical RelevanceVarious psychiatric disorders were observed in children after they had been newly diagnosed with ADHD, indicating a need for integrated care that includes medical practitioners, family members, social workers, and early intervention workers for patients newly diagnosed with ADHD to decrease the risk for comprehensive psychiatric disorders.
Considering Carnegie's Legacy in the Time of Trump: A Science and Policy Agenda for Studying Social Class
Authors: Williams Wendy R. 
Published: January 2019

AbstractAs one of the richest men in the world at a time of vast economic inequality, Andrew Carnegie published “The Gospel of Wealth” in 1889. In it, he delineated how wealth should be redistributed from the hands of the few to the many. Given SPSSI's 2018 conference location in Pittsburgh, and a similar concentration of wealth among a small group of White men today, it is an opportune time to consider the legacy of one of Pittsburgh's most famous citizens. Specifically, the comparison (and contrast) between Carnegie and President Trump provides an interesting backdrop for examining our present historical moment. Specifically, over the last 20 years, there has been renewed interest in studying social class among psychological researchers. Continuing with the conference theme of “building bridges,” this article will review the status of our knowledge about social class in order to provide a science and policy agenda for addressing poverty, wealth, and inequality in our time.