bluuebunny/crossref_metadata_2025_split huggingface dataset:
Healthy lifestyle moderates the association between recent negative life events and depressive symptoms: a cross-sectional study
Authors: Yang Yang , Liao Yuhua , Li Yanzhi , Zhang Huimin , Liu Yifeng , Shi Guangduoji , Hao Jiejing , Chen Ruiying , Xu Ye , Xin Zhiyao , Subi Nuer , Wang Wanxing , Guo Lan , Lu Ciyong , Fan Beifang 
Published: October 2024

Abstract

Background
Both recent negative life events (RNLEs) and lifestyle factors were associated with depressive symptoms, but it is unclear whether adopting a healthy lifestyle can mitigate the association between RNLEs and depressive symptoms. We aim to explore the modifying role of adopting a healthy lifestyle in the association between RNLEs and depressive symptoms.
Method
A cross-sectional study was conducted among 4278 participants aged 18–70 years. RNLEs includes 12 common negative life events that have occurred in the past year, and were classified as low RNLEs (0 RNLEs), intermediate RNLEs (1–5 RNLEs), and high RNLEs (6–12 RNLEs). A healthy lifestyle score in adulthood was constructed as the sum of five modifiable lifestyle factors (i.e., smoking status, drinking status, regular physical activity, sleep duration, and living alone), and was classified as unfavorable [0–2 points], intermediate [3 points], and favorable [4–5 points]) groups. Depressive symptoms were assessed using the 9-item Patient Health Questionnaire. A cut-off value of ≥ 5 was used to identify participants with depressive symptoms.
Results
A total of 1366 (31.9%) participants had depressive symptoms. Individuals with high RNLEs had a higher likelihood of depressive symptoms (odds ratio [OR] = 10.89, 95% confidence interval [95%CI]: 8.59–13.80, P < 0.001) compared to those with low RNLEs. The prevalence of depressive symptoms decreased with the adoption of more favorable lifestyle categories, with the lowest likelihood observed among individuals with a favorable lifestyle (0.30 [0.25–0.37]). Participants with high RNLEs and a favorable lifestyle had an 80% lower association between depressive symptoms and RNLEs (OR = 0.20, 95% CI: 0.14–0.29) compared to those with high RNLEs and an unfavorable lifestyle.
Conclusions
In this cross-sectional study, adopting a greater number of healthy lifestyles was associated with a lower likelihood of depressive symptoms, and mitigated the association between RNLEs and depressive symptoms.
Gender Differences in the Relationship between Sleep, Autonomic Function and Academic Performance: The Role of Sleep and HRV
Authors: Benítez-Agudelo Juan Camilo , Restrepo-Cervantes Dayana , Clemente-Suárez Vicente Javier 
Published: October 2024

Abstract

This study analyzed gender differences in the psychophysiological factors of stress and academic performance among university students. A cross-sectional design was employed with a sample of 601 university students (74.7% women) aged 15 to 47 years. Participants completed assessments on sleep quality, heart rate variability (HRV), personality traits, and psychological indicators such as anxiety, depression, and perceived stress. Results showed that women exhibited higher levels of neuroticism, anxiety, psychological inflexibility, and perceived stress compared to men, yet achieved better academic performance. Regression analysis revealed that sleep quality and HRV parameters, such as heart rate (HR) and the square root of the mean squared differences of successive NN intervals (rMSSD), were positively associated with academic achievement. Despite higher stress levels, female students seemed to employ more effective emotional regulation strategies, contributing to their academic success. These findings highlight the need for gender-sensitive approaches in stress management interventions to improve student well-being and academic outcomes. Future research should consider longitudinal designs to explore the temporal dynamics of stress and academic performance.
Advanced Care Planning in Refugee Patients
Authors: McKeith Amanda , Aldulaimi Sommer , Rivers Patrick , Weiss Barry 
Published: October 2024

Abstract

Advance care planning (ACP) for end-of-life care is an important part of medical care, but fewer than half of older adults in the US have completed ACP documents. Among some population groups, notably African Americans and American Indian/Alaska Natives, rates are even lower. However, there are no published data on the rate of ACP among refugees resettled in the US. We interviewed 36 refugee patients from 15 different countries of origin who were receiving care in a primary care clinic. They ranged in age from 18–77 years, with approximately equal numbers of females and males. We asked them (a) if they knew what ACP documents were and if they did, (b) if they had prepared ACP documents, which we defined as living wills, medical durable power of attorney, or written advanced directive documents. Only 6 (16.6%) of the 36 patients had heard of ACP and only 4 (11.1%) had prepared ACP documents. If they did not have ACP documents, after explaining what they are we asked if they would be interested in discussing ACP with their physician, and 27 (75%) of the 36 said they would be interested in doing so. Our results suggest that the percentage of refugees who have ACPs in place is very low. With the increasing number of refugees entering the US each year, more and more clinicians will be seeing refugees in their practice. They should consider including discussions about ACP in their care of these patients.
A finite element biomechanical study of anterior transpedicular root screw plate fixation
Authors: Xu Xiaoping , Shang Wenzhao , Hou Zhipeng , Zhao Liujun 
Published: October 2024

Abstract

Purpose
To compare the biomechanical properties of anterior transpedicular root screw (ATPRS), anterior transpedicular screw (ATPS) and anterior cervical locked-plate (ACLP) in the lower cervical spine by finite element method.
Methods
We collect CT data of the cervical spine from a healthy 34-year-old adult male volunteer. Use Mimics 10.01 software to build a nonlinear complete model of the lower cervical spine. The model was subjected to 75N axial force and 1.0 N·M to induce various movements. The range of motion (ROM) and stress distribution of each model under different working conditions were compared.
Results
Compared with the intact model, the ROM in the ACLP, ATPS and ATPRS groups decreased to 0.65, 0.58 and 0.62 during flexion and extension. In terms of titanium mesh graft stress, the ATPS and ATPRS groups had the largest load during extension and the smallest load during flexion. In terms of bone-screw interface stress, the peak stress around screw C7 was higher than that around screw C4 during extension in ACLP, ATPS and ATPRS groups, respectively.
Conclusion
Biomechanical characteristics of anterior transpedicular root screw system are favorable.
Frailty mediates the association between activities of daily living disability and depressive symptoms: a prospective cohort study
Authors: Zhang Dongyi , Wei Jinying , Xin Xiuqin , Liu Yan , Zhu Ying , Li Shufei , Chen Hongyue , Meng Guangping 
Published: October 2024

Abstract

Background
Globally, depression is a serious public health problem and it has a high incidence and recurrence rate. The underlying mechanism between the activities of daily living (ADL) disability and depression was not well understood. Our study aimed to explore the mediating role of frailty on the longitudinal association between ADL disability and depressive symptoms.
Methods
This study analyzed data from the China Health and Retirement Longitudinal Study (CHARLS) from 2011 to 2018. A total of 2,245 participants aged ≥45 years old were included. Linear regression, cox regression, and mediation analysis were used to explore the association of ADL disability with development of depressive symptoms and the potential mediating role of frailty.
Results
The results showed that both scores on ADL and frailty were positively associated with the risk of depressive symptoms (P<0.05). No interaction between ADL and covariates on depressive symptoms was found for all subgroups. The association between ADL disability and depressive symptom scores was partially mediated by frailty (mediated proportion = 16.05%) in the Chinese middle-aged and elderly population.
Conclusion
There were positive associations between both scores on ADL and frailty and new-onset depressive symptoms. Individuals with high scores on ADL disability had a higher risk of depressive symptoms, and frailty partially mediated this association.
Fault diagnosis of rolling bearing based on acousto-vibration signal fusion
Authors: Fu Qiang , yi xueliang , lai yanchen , chen hong , ou quankai 
Published: October 2024

Abstract

Typically, accelerometers need to be installed in multiple directions simultaneously to enhance the accuracy of bea-ring fault diagnosis.However, due to certain environmental constraints, it is sometimes Impractical to install accelerometers in multiple directions simultaneously. In contrast, acoustic sensors can overcome the limitations of contact-based measurements but are more susceptible to interference from environmental noise.To address this issue, a novel method for fault diagnosis of rolling bearings that integrates both acoustic and vibration signals is proposed. First, a 2D convolutional fusion layer is employed to process the two types of signals, achieving an initial fusion of the different signals. Secondly, to effectively extract sound-vibration fusion features, a multi-scale CNN-GRU module is introduced to enhance the method's ability to capture features at different scales. Finally, a model pre-training-based transfer learning strategy is used, achieving high performance in experi-ments with an average accuracy exceeding 90%.
Effect of elevation on soil quality under bamboo (Bambusa nutans subsp. cupulata) stands outside forest area in Eastern Nepal
Authors: Ayer Santosh , Poudel Sandip , Adhikari Kishor , Shapkota Jun , Bhatta Kishor Prasad , Maraseni Tek , Maharjan Menuka 
Published: October 2024

Abstract

Globally, bamboo covers 37 million hectares (about 1% of the world’s forests), with over 50% growing outside official forests on degraded, marginal, and agricultural lands. However, little research has explored the relationship between soil properties and bamboo in these non-forest areas, as most studies focus on bamboo forest. Using stratified random sampling, this study assessed soil quality under bamboo stands outside forests in the Udayapur district of Nepal across three elevation zones: lower (0-400 m), middle (400–800 m), and higher (800–1200 m). A total of thirty 100 m² circular plots (10 in each zone) were sampled at two soil depths; the surface layer (0–15 cm) and the subsurface layer (15–30 cm) to assess soil quality using different soil quality indicators. At the 0–15 cm depth, soil organic carbon, total nitrogen, and available potassium were significantly higher at middle elevation (p < 0.05). Available phosphorus and soil pH were significantly higher at middle elevation, while available potassium was significantly higher at higher elevation at 15–30 cm depth (p < 0.05). SQI was higher at the 0-15cm depth (0.53) compared to the 0–30 cm depth (0.49), though this difference was not statistically significant (p > 0.05). Elevation had a significant effect (p < 0.05) on SQI only at the 0–15 cm depth. This study observed significantly higher SQI at middle elevation (0.57) whereas lower SQI at lower elevation (0.48). Further studies with larger samples and broader geographic coverage, incorporating additional soil indicators and environmental variables, could more effectively inform sustainable land management and local livelihood improvements in bamboo stands outside forest areas.
The Molecular Mechanism of Quercetin Improving Cerebral Ischemia Injury by Regulating NLRP3 Inflammasome Mediated Pyroptosis Axis
Authors: Yuan Huiling , Shen Da , Wang Yue , Li Lin , Sang Tingting , Chu Lisheng , Ge Lijun 
Published: October 2024

Abstract

Background
In the pathological process of cerebral ischemia, the neuroinflammation triggered by NLRP3 inflammasome-mediated neuronal pyroptosis is considered a crucial factor contributing to brain damage. Although, previous research has revealed the anti-inflammatory and neuroprotective effects of quercetin (Que), its precise mechanisms in intervening and alleviating neuroinflammation and the pyroptosis axis triggered by cerebral ischemia remain to be fully elucidated.
Objective
To investigate the role and mechanism of Que in alleviating cerebral ischemia injury by modulating the NLRP3 inflammasome-mediated pyroptosis axis.
Methods
The oxygen-glucose deprivation and reperfusion (OGD/R) model with BV2 microglial cells and the photothrombosis (PT) model with C57/BL male mice were utilized. The study explored the neuroprotective effect of Que against cerebral ischemia injury through the regulation of the pyroptosis axis via the NLRP3 inflammasome, assessed through experiments including reactive oxygen species measurement, cell pyroptosis rate detection, behavioral tests, HE staining, Nissl staining, and examination of pyroptosis-related proteins and inflammatory factors.
Results
Que alleviated cell damage and pyroptosis induced by OGD/R, reduced intracellular reactive oxygen species levels, improved behavioral impairment in mice after modeling, decreased brain injury area, maintained neuronal morphology, and lowered the expression of pyroptosis axis-related proteins such as NLRP3, Caspase-1, ASC, GSDMD, as well as inflammatory factors IL-18, IL-1β, TNF-α.
Conclusion
Que alleviated cerebral ischemia injury by regulating the pyroptosis axis through inhibiting the activation of NLRP3 inflammasome. This provides robust experimental evidence for the anti-neuroinflammatory effects of Que and the development of neuroprotective drugs.
«ВАРВАРСКИЙ» ЛАНДШАФТ И АНТИЧНЫЕ ФОРМЫ ОБЩЕЖИТИЯ: НЕСКОЛЬКО СЮЖЕТОВ ИЗ ИСТОРИИ ДРЕВНЕГРЕЧЕСКИХ КОЛОНИЙ В СЕВЕРНОМ ПРИЧЕРНОМОРЬЕ
Authors: И.Е. СУРИКОВ 
Published: October 2024

Глава включает в себя три очерка, освещающих различные аспекты ландшафтного (включая климатическое) влияния на жизнь древнегреческих колоний и колонистов в «варварском» северопричерноморском регионе. В первом очерке рассматриваются причины распространенности земляночного домостроительства у тамошних эллинов на первом этапе истории их полисов и, в частности, предлагается ответ на вопрос о том, имело ли в данном отношении место влияние на них со стороны местных варваров. Предмет второго очерка — специфика расселения в Крыму античных греков, которые, в отличие от своих византийских потомков, совершенно избегали освоения благодатного во всех смыслах южного побережья полуострова. Третий очерк предлагает некоторые перспективы прочтения источников, появляющиеся в связи с аргументированной гипотезой о существовании в I тыс. до н.э. впоследствии исчезнувшего пролива — восточного «дублера» Боспора Киммерийского; под этим углом зрения проанализирован известный рассказ Диодора о войне между сыновьями Перисада I.
This chapter includes three essays, which highlight various aspects of the influence of landscape (climate included) on the life of Greek colonies and colonists in the «Barbaric» Northern Pontic area. The first essay deals with the reasons of popularity of dugout house-building with the local Hellenes at the first stage of their poleis’ history and, in particular, offers an answer to the question whether in this respect influence on them took place on the part of local Barbarians. The subject of the second essay is some specific features of the settling in the Crimea of Ancient Greeks, who, unlike their Byzantine descendants, totally kept off the southern shore of the peninsula, which is a land of plenty. The third essay offers some new prospects in the reading of sources, which appeared in connection with the well-reasoned hypothesis about the existence in the first millennium B.C. of a strait (now extinct) that was an eastern “dub” of the Cimmerian Bosporus; from this standpoint, the well-known story of Diodorus about the war between Paerisades I’s sons is analyzed.
ФОРМЫ ВАРВАРСКОГО ПОВЕДЕНИЯ В СРЕДНЕВЕКОВОМ ГОРОДЕ (ФРАНЦИЯ, XIV–XV ВВ.)
Authors: М.В. КУЗЬМИНА 
Published: October 2024

Глава посвящена рассмотрению вопроса о влиянии городского ландшафта и городской среды на поведение человека в Средние века. Именно благодаря особенностям городской жизни — скученности, плотной застройке, не дававшей возможности вести вполне уединённую жизнь, зависимости от мнения соседей, строго следящих за жизнью каждого члена общества; необходимости эмоциональной разрядки в играх и других развлечениях, из которых одни требовали больших пространств, и поэтому порой приобретали странные формы, другие же, такие как таверны и публичные дома, как раз благодаря своей востребованности становились не только центрами проведения досуга и социализации, но и криминальным местом, куда стекались люди различных социальных групп — варварское в людях получало выход в виде сверхагрессивных поступков, вплоть до убийств.
The chapter is devoted to the consideration of the issue of the influence of the urban landscape and urban environment on human behavior in the Middle Ages. It is due to the peculiarities of urban life — crowding, dense development, which did not allow for a completely secluded life, dependence on the opinion of neighbors, strictly monitoring the life of each member of society; the need of emotional release in games and other entertainment, some of which required large spaces, and therefore sometimes acquired strange forms, while others, such as taverns and brothels, precisely due to their demand, became not only the centers of socialization and leisure, but also a criminal place where people of various social groups flocked to — the barbaric in people found an outlet in the form of super-aggressive actions, including murder.
Recent Advancement in Drug Designing as Small Molecules in Targeted Cancer Therapy: Challenges and Future Directions
Authors: Prakash Satya , Tyagi Priyanka , Singh Pratibha , Rajkumar  , Singh Atul Pratap 
Published: October 2024

Abstract:
The adverse outcome that patients experience as a result of anti-cancer therapy failure is primarily caused by metastasis. Making cancer a chronic disease with regular but controlled relapses is the real issue in increasing cancer patient lifespans. This can only be achieved by developing efficient therapeutic techniques that target critical targets in the metastatic process. New targeted therapy medications continue to emerge, and research into the molecular targeted therapy of tumors is flourishing. The ineffectiveness of conventional chemotherapy in targeting metastatic cells is primarily due to its ability to promote the selection of chemo-resistant cell populations that engage in epithelial-to-mesenchymal transition (EMT), which in turn encourages the colonization of distant sites and maintains the initial metastatic process. In considering this circumstance, research into a broad range of small molecules and biologics has been initiated to develop anti-metastatic medications that target particular targets implicated in the different stages of metastasis. With their ability to concentrate on cancer cells while avoiding normal cells, tar-geted medications offer a promising alternative to conventional chemotherapy that is both highly effective and relatively safe. Many obstacles, including an inadequate response rate and drug resistance, persist for small-molecule targeted anti-cancer medications, despite significant ad-vancements in this area. We encouraged small-molecule-focused anti-cancer therapy develop-ment by extensively assessing them by target classification. We reviewed current challenges, listed licenced drugs and key drug candidates in clinical trials for each target, and made sugges-tions for improving anti-cancer drug research and development. This review aims to discuss pre-sent and future small molecule inhibitor research and development for cancer treatment.
Discovery of Two GSK3β Inhibitors from Sophora flavescens Ait. using Structure-based Virtual Screening and Bioactivity Evaluation
Authors: Pan Dabo , Zeng Yong , Jiang Dewen , Zhang Yonghao , Wu Mingkai , Huang Yaxuan , Han Minzhen , Jin Xiao-jie 
Published: October 2024

Objective:
Kushen (Sophora flavescens Ait.) has a long history of medicinal use in China
due to its medicinal values, such as antibacterial, antiviral, and anti-inflammatory. Rapid discovery
of the components and the medicinal effects exerted by Kushen will help elucidate the science
of Kushen in curing diseases. GSK3β (glycogen synthase kinase-3 beta) is a protein kinase
with a wide range of physiological functions, such as antibacterial, antiviral, and anti-inflammatory.
The discovery of inhibitors targeting GSK3β from Kushen was not only helpful for the rapid
discovery of the components responsible for the efficacy of Kushen but also important for the development
of novel drugs.

Methods:
In this study, the chemical composition of Kushen was extracted from the TMSCP
database. Molecular docking, GSK3β enzyme assay, and molecular dynamics simulations were
used to discover the GSK3β inhibitors from the chemical composition of Kushen.

Results:
A total of 113 chemical compositions of Kushen were extracted from the TMSCP
database. Molecular docking indicated that 15 chemical compositions of Kushen scored better
than -8 kcal/mol against GSK3β. GSK3β enzyme assay demonstrated several inhibitory activities
of kushenol I and kushenol F with IC50 values of 7.53 ± 2.55 μM and 4.96 ± 1.29 μM, respectively.
Molecular dynamics simulations were used to reveal the interactions of kushenol I and
kushenol F with GSK3β from structural and energetic perspectives.

Conclusion:
Kushenol I and kushenol F could be the material basis for the antibacterial, antiviral,
and anti-inflammatory properties of Kushen.
Evaluating the Effectiveness of Ahmed Glaucoma Valve Implantation in Reducing Intraocular Pressure in Refractory Glaucoma in the Saudi Arabian Population at a Tertiary Care Centre
Authors: Almarzouki Nawaf 
Published: October 2024

Objectives: To assess the efficacy of Ahmed glaucoma valve implantation (AGVI) in lowering intraocular pressure (IOP) in patients with refractory glaucoma.
Methods: In this retrospective study, we analyzed the medical records of 60 patients who received AGVI for refractory glaucoma. Data collected included demographics, type of glaucoma, preoperative and postoperative IOP, number of glaucoma medications, and any surgical complications. Success was defined as achieving an IOP <21 mmHg at the final follow-up visit.
Results: At the final follow-up (mean duration of 11.6 months), AGVI achieved successful IOP control (IOP of <21 mmHg) in 40 eyes (66.7%). The mean number of glaucoma medications decreased significantly from 2.95 preoperatively to 1.98 postoperatively (p < 0.001). Neovascular glaucoma (NVG) had a lower success rate compared to other types of glaucoma. Prior glaucoma surgery was associated with a higher risk of failing to reach target IOP, although this trend was not statistically significant (p = 0.108).
Conclusion: AGVI implantation effectively lowered IOP in patients with refractory glaucoma, especially in the short term. However, long-term success rates were lower, and NVG showed less favorable outcomes. AGVI is a valuable option for managing refractory glaucoma, but careful patient selection is essential. Further research is needed to evaluate long-term efficacy and refine treatment strategies.