bluuebunny/crossref_metadata_2025_split huggingface dataset:
Slot-like capacity and resource-like coding in a neural model of multiple-item working memory
Authors: Standage Dominic , Paré Martin 
Published: June 2018

For the past decade, research on the storage limitations of working memory has been dominated by two fundamentally different hypotheses. On the one hand, the contents of working memory may be stored in a limited number of “slots,” each with a fixed resolution. On the other hand, any number of items may be stored but with decreasing resolution. These two hypotheses have been invaluable in characterizing the computational structure of working memory, but neither provides a complete account of the available experimental data or speaks to the neural basis of the limitations it characterizes. To address these shortcomings, we simulated a multiple-item working memory task with a cortical network model, the cellular resolution of which allowed us to quantify the coding fidelity of memoranda as a function of memory load, as measured by the discriminability, regularity, and reliability of simulated neural spiking. Our simulations account for a wealth of neural and behavioral data from human and nonhuman primate studies, and they demonstrate that feedback inhibition lowers both capacity and coding fidelity. Because the strength of inhibition scales with the number of items stored by the network, increasing this number progressively lowers fidelity until capacity is reached. Crucially, the model makes specific, testable predictions for neural activity on multiple-item working memory tasks.NEW & NOTEWORTHY Working memory is the ability to keep information in mind and is fundamental to cognition. It is actively debated whether the storage limitations of working memory reflect a small number of storage units (slots) or a decrease in coding resolution as a limited resource is allocated to more items. In a cortical model, we found that slot-like capacity and resource-like neural coding resulted from the same mechanism, offering an integrated explanation for storage limitations.
Effects of Repeated Binge Drinking on Blood Pressure Levels and Other Cardiovascular Health Metrics in Young Adults: National Health and Nutrition Examination Survey, 2011‐2014
Authors: Piano Mariann R. , Burke Larisa , Kang Minkyung , Phillips Shane A. 
Published: June 2018

Background

Binge drinking prevalence rates are highest in young adults; however, little is known about the effects of binge drinking on blood pressure (
BP
) and other cardiovascular health metrics in individuals between 18 and 45 years of age. The aim of this study was to determine the effects of regular binge drinking on
BP
, lipid and glucose levels and to determine if there were differences in these associations between men and women.

Methods and Results

We analyzed data from NHANES (the US National Health and Nutrition Examination Survey) for men and women 18 to 45 years old who were non–binge drinkers, binge drank 1 to 12 times, or binge drank >12 times in the past year. After controlling for diet and physical activity, both categories of men binge drinkers compared with non–binge drinkers had higher systolic
BP
(121.8 and 119.0 mm Hg versus 117.5 mm Hg) and total cholesterol (215.5 and 217.9 mg/dL versus 207.8 mg/dL) values. There were no effects of binge drinking on systolic
BP
or total cholesterol in women. Binge drinking in men and women was associated with higher high‐density lipoprotein‐cholesterol values. The effects of binge drinking on glucose parameters in men and women were variable.

Conclusions

Compared with young adult women, repeated binge drinking in men was associated with an elevated systolic
BP
, and greater frequency of binge drinking in men was associated with a more unfavorable lipid profile. In young adults with elevated systolic
BP
, practitioners should consider the possible role of binge drinking and address the importance of reducing alcohol intake as an important cardiovascular risk reduction strategy.
Bringing Ethics to Wild Lives: Shaping Public Policy for Barred and Northern Spotted Owls
Authors: Lynn William S. 
Published: June 2018

AbstractEthics reviews are not part of environmental policy or wildlife management in the United States. This changed when, for the first time, theUSFish and Wildlife Service conducted such a review with respect to the barred and northern spotted owls. Spotted owls are endangered throughout their range by a variety of anthropogenic and natural forces. The interspecific competition between barred and spotted owls is a key factor second only to habitat destruction. A proposed lethal experiment to remove barred owls raised ethical concerns among wildlife agencies, citizens, and advocacy groups. Seeking to better understand these concerns, the Service created the Barred Owl Stakeholder Group. Using an innovative method and instrument in the form of an ethics-based policy dialogue and an ethics brief, the stakeholder group explored the ethical dimensions of the removal experiment. This process holds lessons for how public policy can bring ethics to bear on wild lives.
Energy drinks, caffeine, junk food, breakfast, depression and academic attainment of secondary school students
Authors: Smith Andrew P , Richards Gareth 
Published: June 2018

Background: Energy drinks are widely consumed, and concerns have been raised about possible negative outcomes. Aims: The aim of the present research was to examine associations between consumption of energy drinks, caffeine and junk food, and academic attainment in a sample of UK secondary school students. Methods: A total of 3071 students agreed to participate in the study; 2677 completed the survey on one occasion (52.4% female, 47.6% male; approximately 20% of the sample from each school year) and 1660 (49.6% female, 50.4% male) completed the survey a second time, approximately six months later. The academic attainment measure was based on Key Stage 3 and Key Stage 4 grades for Maths and English. Results: In the cross-sectional analyses, logistic regressions showed that consumption of energy drinks was associated with a greater likelihood of being in the low academic achievement group. This was not found for other sources of caffeine. The effect of energy drinks was still significant when demographic, academic and health/lifestyle variables were covaried. However, inclusion of an unhealthy diet variable (junk food) removed the significant effect of energy drinks. Similar observations were made in the longitudinal study, with the poorer attainment of those who consumed energy drinks reflecting breakfast omission and depression. Discussion: The present findings indicate that consumption of energy drinks is associated with an increased likelihood of poor academic attainment that reflects energy drink consumption being part of an unhealthy diet or being associated with skipping breakfast rather than a more specific effect, such as being a source of caffeine. Although the current study extends previous research by utilising a longitudinal design, intervention studies are now required to better answer questions relating to causality and direction of effect.
Return to Sport After Surgical Treatment for Anterior Shoulder Instability: A Systematic Review
Authors: Abdul-Rassoul Hussein , Galvin Joseph W. , Curry Emily J. , Simon Jason , Li Xinning 
Published: June 2018

Background: For athletes, a return to preinjury activity levels with minimal time away is a metric indicative of successful recovery. The knowledge of this metric would be helpful for the sports medicine specialist to advise patients on appropriate expectations after surgery. Purpose: To evaluate the rate and amount of time needed for athletes to return to sport (RTS) after different surgical treatments for anterior shoulder instability. Study Design: Systematic review and meta-analysis. Methods: The MEDLINE, EMBASE, and Cochrane databases were searched for articles relevant to athletes’ RTS after surgical anterior shoulder stabilization with variants of the Latarjet and Bankart procedures. Article selection was based on relevant inclusion and exclusion criteria. After the articles were reviewed, the data pertinent to rates of and time to RTS were extracted, compiled, and analyzed. Results: Sixteen articles met the inclusion criteria. Based on these articles, the rate of RTS was 97.5% after arthroscopic Bankart, 86.1% after open Bankart, 83.6% after open Latarjet, 94.0% after arthroscopic Latarjet, and 95.5% after arthroscopic Bankart with remplissage. Among the athletes who did RTS, arthroscopic Bankart had the highest rate of return to preinjury levels (91.5%), while arthroscopic Latarjet had the lowest rate (69.0%). The time to RTS was 5.9 months after arthroscopic Bankart, 8.2 months after open Bankart, 5.07 months after open Latarjet, 5.86 months after arthroscopic Latarjet, and 7 months after arthroscopic Bankart with remplissage. Conclusion: Of the pooled data, patients who underwent arthroscopic Bankart showed the highest rate of RTS, while patients who underwent open Latarjet showed the shortest time to RTS. Return to preinjury level was highest in the arthroscopic Bankart group and lowest in the arthroscopic Latarjet group. Physicians can utilize these data to set expectations for their patient-athletes regarding RTS after anterior shoulder stabilization procedures. Clinical Relevance: When treating an athlete, many factors must be taken into account to weigh treatment options. Two important factors to consider with the patient-athlete are the rate of return to the previous activity level and the timeline for this to occur. This study provides a guide for physicians and a time frame for athletes with respect to the mean percentage and time for return to sport after different surgical procedures for anterior shoulder instability.
Refugees as the Other: Large-group identity, terrorism and border psychology
Authors: Volkan Vamık D. 
Published: June 2018

On 27 August, 2015 two vessels with 550 migrants on board sank off the Libyan coast, and more than 400 persons were estimated to have drowned. Some credit this event as having coined the phrase ‘European refugee crisis’ that is still used to describe the present refugee situation in Europe. On 13 November 2015 a series of coordinated terrorist attacks took place in Paris and a northern suburb of the city. When a Syrian passport that belonged to an asylum seeker was found near the body of one of the gunmen, fear of Islamic State militants disguised as asylum seekers or refugees spread. This event, linked to similar tragedies that have occurred in many other countries before and since, evolved as a major symbol linking newcomers, and refugees in general, to terrorism and extreme forms of Islam. When observing newcomers and local people in different host countries, in addition to accompanying societal reactions to multiple traumas, medical problems, legal, political, financial and other practical issues and security concerns, there is always an increased investment in large-group identity by both refugees and persons in the host countries. This article does not explore the psychology of asylum seekers, immigrants or refugees. It describes what large-group identity is, how it develops and why a population’s preoccupation with physical borders increases. Its aim is to examine shared psychological processes in European countries and the United States that manifest when perception of newcomers as the dangerous Other takes place.
A Voice Needs to be Heard: The Meaning of “Going Home”
Authors: Shimoinaba Kaori , Lee Susan , Johnson Claire E. 
Published: June 2018

Background: This case report addresses a client from a minority cultural background in Australia and her complex cultural needs at the end of life. Case History: A 66-year-old Japanese female client diagnosed with renal cancer, and lung and spine metastasis shared her story. Since a left nephrectomy in 2007, she has had hemodialysis 3 days a week. She left Japan more than 30 years ago and moved to Australia 20 years ago. With the 6-month prognosis, she expressed her desire to “go home.” The meaning of “going home” was explored with the author who shares the same cultural background and language and is a palliative care nurse. The meanings for wanting to go home were her nostalgia for the traditional food, language, land, and death rituals. Discussion: The client identified her preferred place to die and discussed her death wishes. Open, honest communication with health professionals about her condition and prognosis facilitated meaningful discussions. Conclusion: The narrative demonstrates the complex issues and needs of clients from minority cultural backgrounds and the importance of understanding the real cultural meaning behind their stories. Exploring the meaning with compassionate curiosity as well as interpretation support was the key.
The Impact of Maxillary Advancement on Consonant Proficiency in Patients With Cleft Lip and Palate, Lay Listeners’ Opinion, and Patients’ Satisfaction With Speech
Authors: Hagberg Emilie , Flodin Stina , Granqvist Svante , Karsten Agneta , Neovius Erik , Lohmander Anette 
Published: June 2018

Objective: This study investigates the impact of maxillary advancement (Le Fort I osteotomy) on consonant proficiency in patients with cleft lip and palate (CLP) and explores how these patients and lay people perceive their speech 1 year post Le Fort I osteotomy. Design: Retrospective group study before and after treatment. Participants: All patients with CLP who had undergone Le Fort I osteotomy for maxillary retrognathia between 2007 and 2010 at Karolinska University Hospital, Sweden (n = 21). Six patients were excluded due to additional malformations and missing data. Two experienced speech and language pathologists assessed consonant proficiency, and speech accuracy was determined by lay listeners from pre- and postoperative standardized audio recordings. The patients’ satisfaction with speech postoperatively was collected from medical records. Main Outcome Measures: Percentage of oral consonants correct and acoustic analysis of /s/, lay listeners’ opinion, and patients’ satisfaction with speech. Results: One year postoperation, 11 of the 15 patients had improved articulation, especially on the /s/-sound, without speech intervention. The mean percentage of oral consonants correct before treatment (82%) was significantly improved later (95%; P > .01). This assessment was supported by the patients’ satisfaction with speech. However, lay listeners’ opinion on accuracy was inconsistent. Length of maxillary advancement or change in occlusion did not correlate with change in articulation. Conclusion: Maxillary advancement performed to normalize occlusion and facial profile improved consonant proficiency in patients with CLP 1 year postoperation. Lay listeners’ and patients’ perceptions of speech need further exploration.
Significant drug interaction between voriconazole and dexamethasone: A case report
Authors: Taghvaye Masoumi Hamidreza , Hadjibabaie Molouk , Gholami Kheirollah , Zarif-Yeganeh Morvarid , Ghavamzadeh Ardeshir 
Published: June 2018

Background Voriconazole is extensively metabolized by the CYP450 isoenzymes 2C19 and 3A4 and to a lesser extent by CYP2C9; therefore, any medication that affects this pathway can alter its plasma concentration. Treatment failure can probably occur if subtherapeutic levels are achieved. Case description A 32-year-old woman who suffered from acute lymphoblastic leukemia was admitted and received treatment with vincristine and dexamethasone. After several days, to control her fever, based on two consecutive positive serum galactomannan test results, voriconazole as an antifungal agent was added to Aspergillus infection treatment. Through the first week after voriconazole initiation, its plasma concentrations were subtherapeutic. The most suspicious medication for interaction was dexamethasone, which can induce CYP450 isoenzymes and reduce plasma concentration. Conclusion As a result of the narrow therapeutic window of voriconazole and the relationship between efficacy and plasma concentration of azoles, therapeutic drug monitoring of voriconazole in patients receiving a high dose of glucocorticoids is recommended, in order to achieve optimal response to treatment and toxicity reduction. Further studies regarding the interaction between voriconazole and dexamethasone to prevent clinically relevant interactions should be considered.
Parents’ Expressions of Concerns and Hopes for the Future and Their Concomitant Assessments of Disability in Their Children
Authors: Illum Niels Ove , Bonderup Mette , Gradel Kim Oren 
Published: June 2018

Aim: To assess parents’ ability to express their concerns and hopes for the future in their children with disability and assess their children’s disability as well as to analyse these data for consistency. Method: Parents of 162 children with spina bifida, spinal muscular atrophy, muscular disorders, cerebral palsy, visual impairment, hearing impairment, mental disability, or disability following brain tumours were asked to freely express their concerns and hopes for the future and to assess disability in their own children by employing a set of 26 International Classification of Functioning, Disability and Health, Children and Youth Version (ICF-CY) body function (b) codes and activity and participation (d) codes. A grounded theory approach was employed to systematize parents’ expressions of concerns and hopes; then, parents scored qualifiers on a 5-step qualitative Likert scale. Parents assessed their children’s disability in the same way using the ICF-CY 5-step qualifier scale. Results: Altogether, 119 parents freely expressed their concerns and hopes, and 101 of them also assessed their children’s disability using the 26 ICF-CY codes. A total of 475 expressions of concern and hopes (issues) were expressed and categorized into 34 areas of concern and hopes (subsections). The most frequently mentioned issues were education; understanding, goodwill, and communication between parents; and community support. Qualitative data on both 5-step qualifier scales showed good reliability. Rasch analysis maps on concerns and hopes for children as well as on the ICF-CY assessment demonstrated good alignment and a clinically relevant progression from the least to the most disabled children. Conclusion: Parents can express valid and reliable data on their concerns and hopes for the future and can reliably assess disability in their own children.
The impact of bilingualism on executive function in adolescents
Authors: Chung-Fat-Yim Ashley , Himel Cari , Bialystok Ellen 
Published: June 2018

Aims and objectives/purpose/research questions: In early childhood and older adulthood, bilinguals generally demonstrate better performance on executive function tasks than their monolingual counterparts, but in the young adult population, these differences are infrequently observed. However, few studies have examined these effects in the adolescent population, so the trajectory of these changes is unclear. The objective of the study was to compare performance on a modified flanker task for monolingual and bilingual adolescents, a time when the executive functions are still developing. Design/methodology/approach: The flanker task was adapted by including a rule-switching component and contained three blocks: (1) rule; (2) flanker; and (3) mixed. In the rule block, a single red or blue arrow (indicated by light grey or medium grey in Figure 1) denoted a response rule; for example, a blue arrow signaled pressing the button indicating the direction the arrow was pointing but a red arrow signaled pressing the button indicating the opposite direction. The flanker block was a standard flanker task consisting of congruent and incongruent trials. The mixed block manipulated both congruency and rule conditions. Data and analysis: Mean reaction times and accuracy from 33 monolingual and 32 bilingual adolescents were analyzed using a repeated-measures analysis of variance with language group as the between-subjects variable and congruency and/or rule-type as the within-subjects variable depending on the block. Findings/conclusions: Bilingual adolescents outperformed monolingual adolescents but only on the block that was most similar to the standard flanker task. The blocks with the rule-switching component yielded equivalent performance. Originality: Unlike previous studies, the current study adapted a simple executive control task to require greater attentional resources by manipulating task demands. Significance/implications: Our findings add to the growing body of literature examining bilingualism and executive control in the adolescent population and fill in the gap in our understanding of the lifespan trajectory of these effects.
Cardiovascular outcomes in patients who experienced a myocardial infarction while treated with liraglutide versus placebo in the LEADER trial
Authors: Nauck Michael A , Tornøe Karen , Rasmussen Søren , Treppendahl Marianne Bach , Marso Steven P 
Published: June 2018

Objective: Animal studies demonstrated that glucagon-like peptide-1 receptor agonists reduce myocardial necrosis following regional ischaemia induction. This effect may improve cardiovascular outcomes after myocardial infarction. Risk of cardiovascular death or hospitalisation for heart failure after myocardial infarction was evaluated in patients with type 2 diabetes at high cardiovascular risk in the LEADER trial. Methods: Data from patients randomised to liraglutide or placebo, in addition to standard of care, in Liraglutide Effect and Action in Diabetes: Evaluation of Cardiovascular Outcome Results (LEADER) (NCT01179048) were analysed post hoc. Cox regression, with myocardial infarction as a time-dependent covariate, was used to analyse time from randomisation to a composite of cardiovascular death or hospitalisation for heart failure. Results: Patients who experienced myocardial infarction had a sevenfold higher risk of the composite endpoint (with myocardial infarction: n = 148, 25.0%; without myocardial infarction: n = 716, 8.2%; hazard ratio: 7.0; 95% confidence interval: 5.8, 8.4). The risk of the composite endpoint after myocardial infarction was not significantly lower in the liraglutide group ( n = 63, 23.0%) compared with placebo ( n = 85, 26.7%; hazard ratio: 0.91; 95% confidence interval: 0.66, 1.26). Conclusion: The data demonstrated that having myocardial infarction significantly increased the risk of subsequent cardiovascular death or hospitalisation for heart failure. However, we did not find evidence for a reduced risk in these cardiovascular outcomes following myocardial infarction in patients treated with liraglutide versus placebo.