bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association between physical, psychological and social frailty and health-related quality of life among older people
Authors: Zhang Xuxi , Tan Siok Swan , Franse Carmen Betsy , Alhambra-Borrás Tamara , Durá-Ferrandis Estrella , Bilajac Lovorka , Markaki Athina , Verma Arpana , Mattace-Raso Francesco , Voorham Antonius J J , Raat Hein 
Published: May 2019

Abstract

Background
Studies on the association between frailty and health-related quality of life (HRQoL) are scarce and show contradictory results. This study aimed to evaluate the association between physical, psychological and social frailty and HRQoL among community-dwelling older people.

Methods
A cross-sectional study was performed with baseline data collected in 2015 from the Urban Health Centers Europe (UHCE) project in five European countries, the United Kingdom, Greece, Croatia, The Netherlands and Spain. A total of 2325 participants were included in the baseline measurements of the Urban Health Centers Europe project; 2167 participants (mean age = 79.7; SD=5.6) were included in the analyses after excluding participants with missing data. The Tilburg Frailty Indicator measured overall frailty as well as physical, psychological and social frailty. The 12-Item Short-Form Health Survey was used to measured physical and mental HRQoL.

Results
Regarding physical HRQoL, a large difference (d=1.29) between physically and not physically frail participants was observed. Regarding mental HRQoL, a large difference (d=1.20) between psychologically and not psychologically frail participants was observed. In the full model with all three domains of frailty and the covariates to explain physical HRQoL, physical (P &lt;0.001) and social frailty (P &lt;0.001) remained significant. In the full model to explain mental HRQoL, all three domains of frailty remained significant (P &lt;0.001).

Conclusion
Physical frailty had the strongest association with physical HRQoL, and psychological frailty had the strongest association with mental HRQoL. The associations between social frailty and both physical and mental HRQoL remain significant when controlling for physical and psychological frailty.
Incorporating costing study results into district and service planning to enhance immunization programme performance: a Zambian case study
Authors: Feldhaus Isabelle , Schütte Carl , Mwansa Francis D , Undi Masauso , Banda Stanley , Suharlim Chris , Menzies Nicolas A , Brenzel Logan , Resch Stephen C , Kinghorn Anthony 
Published: May 2019

Abstract
Donors, researchers and international agencies have made significant investments in collection of high-quality data on immunization costs, aiming to improve the efficiency and sustainability of services. However, improved quality and routine dissemination of costing information to local managers may not lead to enhanced programme performance. This study explored how district- and service-level managers can use costing information to enhance planning and management to increase immunization outputs and coverage. Data on the use of costing information in the planning and management of Zambia’s immunization programme was obtained through individual and group semi-structured interviews with planners and managers at national, provincial and district levels. Document review revealed the organizational context within which managers operated. Qualitative results described managers’ ability to use costing information to generate cost and efficiency indicators not provided by existing systems. These, in turn, would allow them to understand the relative cost of vaccines and other resources, increase awareness of resource use and management, benchmark against other facilities and districts, and modify strategies to improve performance. Managers indicated that costing information highlighted priorities for more efficient use of human resources, vaccines and outreach for immunization programming. Despite decentralization, there were limitations on managers’ decision-making to improve programme efficiency in practice: major resource allocation decisions were made centrally and planning tools did not focus on vaccine costs. Unreliable budgets and disbursements also undermined managers’ ability to use systems and information. Routine generation and use of immunization cost information may have limited impact on managing efficiency in many Zambian districts, but opportunities were evident for using existing capacity and systems to improve efficiency. Simpler approaches, such as improving reliability and use of routine immunization and staffing indicators, drawing on general insights from periodic costing studies, and focusing on maximizing coverage with available resources, may be more feasible in the short-term.
Bark in Woody Plants: Understanding the Diversity of a Multifunctional Structure
Authors: Rosell Julieta A 
Published: May 2019

AbstractMost biological structures carry out multiple functions. Focusing on only one function to make adaptive inferences overlooks that manifold selection pressures and tradeoffs shape the characteristics of a multifunctional structure. Focusing on single functions can only lead to a partial picture of the causes underlying diversity and the evolutionary origin of the structure in question. I illustrate this discussion using bark as a study case. Bark comprises all the tissues surrounding the xylem in woody plants. Broadly, bark includes an inner and mostly living region and an outer, dead one. Of all plant structures, bark has the most complex anatomical structure and ontogenetic origin involving two (and often three) different meristems. Traditionally, the wide diversity in bark traits, mainly bark thickness, has been interpreted as the result of the selective pressures imposed by fire regime. However, recent research has shown that explanations based on fire regime cannot account for salient patterns of bark variation globally including the very strong inner bark thickness–stem diameter scaling, which is likely due to metabolic needs, and the very high intracommunity variation in total, inner, and outer bark thickness, and in inner:outer proportions. Moreover, explanations based on fire disregard that in addition to fire protection, bark carries out several other crucial functions for plants including translocation of photosynthates; storage of starch, soluble sugars, water, and other compounds; protection from herbivores, pathogens, and high temperatures; wound closure, as well as mechanical support, photosynthesis, and likely being involved in xylem embolism repair. All these functions are crucial for plant performance and are involved in synergistic (e.g., storage of water and insulation) and trade-off relationships (e.g., protection from fire vs photosynthetic activity). Focusing on only one of these functions, protection from fire has provided an incomplete picture of the selective forces shaping bark diversity and has severely hindered our incipient understanding of the functional ecology of this crucial region of woody stems. Applying a multifunctional perspective to the study of bark will allow us to address why we observe such high intracommunity variation in bark traits, why some bark trait combinations are ontogenetically impossible or penalized by selection, how bark is coordinated functionally with other plant parts, and as a result, to understand how bark contributes to the vast diversity of plant ecological strategies across the globe.
Which Line to Follow? The Utility of Different Line-Fitting Methods to Capture the Mechanism of Morphological Scaling
Authors: Shingleton Alexander W 
Published: May 2019

AbstractBivariate morphological scaling relationships describe how the sizes of two traits co-vary among adults in a population. In as much as body shape is reflected by the relative size of various traits within the body, morphological scaling relationships capture how body shape varies with size, and therefore have been used widely as descriptors of morphological variation within and among species. Despite their extensive use, there is continuing discussion over which line-fitting method should be used to describe linear morphological scaling relationships. Here I argue that the “best” line-fitting method is the one that most accurately captures the proximate developmental mechanisms that generate scaling relationships. Using mathematical modeling, I show that the “best” line-fitting method depends on the pattern of variation among individuals in the developmental mechanisms that regulate trait size. For Drosophila traits, this pattern of variation indicates that major axis regression is the best line-fitting method. For morphological traits in other animals, however, other line-fitting methods may be more accurate. I provide a simple web-based application for researchers to explore how different line-fitting methods perform on their own morphological data.
Transcranial Magnetic Stimulation Markers of Antidepressant Treatment in Adolescents With Major Depressive Disorder
Authors: Doruk Camsari Deniz , Lewis Charles P , Sonmez Ayse Irem , Nandakumar Aiswarya Laks , Gresbrink Marjorie A , Daskalakis Zafiris J , Croarkin Paul E 
Published: May 2019

AbstractBackgroundThe goal of this study was to examine baseline transcranial magnetic stimulation measures of cortical inhibition and excitability in depressed patients and characterize their longitudinal posttreatment changes.MethodsFifteen adolescents (age 13–17 years) with moderate to severe major depressive disorder and 22 healthy controls (age 9–17) underwent single- and paired-pulse transcranial magnetic stimulation and clinical assessments. Transcranial magnetic stimulation measures included short-interval intracortical inhibition (2 and 4 milliseconds), long-interval intracortical inhibition (100, 150, and 200 milliseconds), cortical silent period, and intracortical facilitation (10, 15, and 20 milliseconds). Ten participants with major depressive disorder initiated antidepressant treatment or had dose adjustments. These participants were reassessed after treatment. Depression symptom severity was measured with the Children’s Depression Rating Scale, Revised. Robust regression modeling compared healthy and depressed adolescents at baseline. Relationships between changes in cortical inhibition and changes in depressive symptom severity were assessed in the depressed adolescents receiving antidepressant treatment.ResultsOur results revealed that at baseline, short-interval intracortical inhibition-2 was significantly reduced (Padj = .01) in depressed participants, suggesting impaired cortical inhibition compared with healthy controls. At follow-up, improvement in Children’s Depression Rating Scale, Revised scores correlated with improvement in short-interval intracortical inhibition-4 amplitude (greater inhibition) after antidepressant treatment (R2 = 0.63; P = .01).ConclusionsThese results suggest that cortical inhibition measures may have promise as biomarkers in adolescents treated for depression.
An explanatory model of temperature influence on flowering through whole-plant accumulation of FLOWERING LOCUS T in Arabidopsis thaliana
Authors: Kinmonth-Schultz Hannah A , MacEwen Melissa J S , Seaton Daniel D , Millar Andrew J , Imaizumi Takato , Kim Soo-Hyung 
Published: May 2019

Abstract
We assessed mechanistic temperature influence on flowering by incorporating temperature-responsive flowering mechanisms across developmental age into an existing model. Temperature influences the leaf production rate as well as expression of FLOWERING LOCUS T (FT), a photoperiodic flowering regulator that is expressed in leaves. The Arabidopsis Framework Model incorporated temperature influence on leaf growth but ignored the consequences of leaf growth on and direct temperature influence of FT expression. We measured FT production in differently aged leaves and modified the model, adding mechanistic temperature influence on FT transcription, and causing whole-plant FT to accumulate with leaf growth. Our simulations suggest that in long days, the developmental stage (leaf number) at which the reproductive transition occurs is influenced by day length and temperature through FT, while temperature influences the rate of leaf production and the time (in days) the transition occurs. Further, we demonstrate that FT is mainly produced in the first 10 leaves in the Columbia (Col-0) accession, and that FT accumulation alone cannot explain flowering in conditions in which flowering is delayed. Our simulations supported our hypotheses that: (i) temperature regulation of FT, accumulated with leaf growth, is a component of thermal time, and (ii) incorporating mechanistic temperature regulation of FT can improve model predictions when temperatures change over time.
Associations between antimicrobial use and the faecal resistome on broiler farms from nine European countries
Authors: Luiken Roosmarijn E C , Van Gompel Liese , Munk Patrick , Sarrazin Steven , Joosten Philip , Dorado-García Alejandro , Borup Hansen Rasmus , Knudsen Berith E , Bossers Alex , Wagenaar Jaap A , Aarestrup Frank M , Dewulf Jeroen , Mevius Dik J , Heederik Dick J J , Smit Lidwien A M , Schmitt Heike ,   EFFORT consortium, Graveland Haitske , vanEssen Alieda , Gonzalez-Zorn Bruno , Moyano Gabriel , Sanders Pascal , Chauvin Claire , David Julie , Battisti Antonio , Caprioli Andrea , Blaha Thomas , Wadepohl Katharina , Brandt Maximiliane , Hald Tine , Ribeiro Duarte Ana Sofia , Wasyl Dariusz , Skarzyńska Magdalena , Zajac Magdalena , Daskalov Hristo , Saatkamp Helmut W , Stärk Katharina D C 
Published: May 2019

AbstractObjectivesTo determine associations between farm- and flock-level antimicrobial usage (AMU), farm biosecurity status and the abundance of faecal antimicrobial resistance genes (ARGs) on broiler farms.MethodsIn the cross-sectional pan-European EFFORT study, conventional broiler farms were visited and faeces, AMU information and biosecurity records were collected. The resistomes of pooled faecal samples were determined by metagenomic analysis for 176 farms. A meta-analysis approach was used to relate total and class-specific ARGs (expressed as fragments per kb reference per million bacterial fragments, FPKM) to AMU (treatment incidence per DDD, TIDDDvet) per country and subsequently across all countries. In a similar way, the association between biosecurity status (Biocheck.UGent) and the resistome was explored.ResultsSixty-six (38%) flocks did not report group treatments but showed a similar resistome composition and roughly similar ARG levels to antimicrobial-treated flocks. Nevertheless, we found significant positive associations between β-lactam, tetracycline, macrolide and lincosamide, trimethoprim and aminoglycoside antimicrobial flock treatments and ARG clusters conferring resistance to the same class. Similar associations were found with purchased products. In gene-level analysis for β-lactams and macrolides, lincosamides and streptogramins, a significant positive association was found with the most abundant gene clusters blaTEM and erm(B). Little evidence was found for associations with biosecurity.ConclusionsThe faecal microbiome in European broilers contains a high diversity of ARGs, even in the absence of current antimicrobial selection pressure. Despite this, the relative abundance of genes and the composition of the resistome is positively related to AMU in European broiler farms for several antimicrobial classes.
Regulating Cross-Border Data Flows in a Data-Driven World: How WTO Law Can Contribute
Authors: Mitchell Andrew D , Mishra Neha 
Published: May 2019

Abstract
While the free cross-border movement of data is essential to many aspects of international trade, several countries have imposed restrictions on these data flows. The pre-internet rules of the World Trade Organization (`WTO') discipline some of these restrictions, but they are insufficient. Unfortunately, so are the electronic commerce chapters in modern preferential trade agreements. This article argues that reformed WTO rules, which take account of the policy challenges of the data-driven economy, are required. These reforms would facilitate internet openness while ensuring consumer and business trust, promoting digital inclusion of developing countries, and incorporating clear exceptions for legitimate domestic policies.
Information Sharing and Incentives in Organizations
Authors: de Bettignies Jean-Etienne , Zabojnik Jan 
Published: May 2019

Abstract
We study an organization, consisting of a manager and a worker, whose success depends on its ability to estimate a payoff-relevant but unknown parameter. If the manager has private information about this parameter, she has an incentive to conceal it from the worker in order to motivate him to search for additional information. Due to a time-inconsistency problem, the manager conceals her information more often than if she could commit to an information sharing policy, but even a manager with commitment power shares her information less than would be efficient. We also show that managers who are more likely to get informed are more willing to share their information and that unless the manager’s information substantially improves the worker’s productivity, managerial and worker abilities are substitutes in the firm’s profit function. (JEL D21 D82, L23)
Comparative functional skeletal morphology among three genera of shrews: implications for the evolution of locomotor behavior in the Soricinae (Eulipotyphla: Soricidae)
Authors: Woodman Neal , Wilken Alec T 
Published: May 2019

AbstractThe clade comprising the soricid tribes Blarinellini (Blarinella) and Blarinini (Blarina and Cryptotis) is notable within the Soricidae (Eulipotyphla) for the large proportion of reportedly semifossorial species. To better define locomotor modes among species in these two tribes, we quantified purported locomotor adaptations by calculating 23 functional indices from postcranial measurements obtained from museum specimens of Blarina and Blarinella and published measurements for 16 species of Cryptotis. We then analyzed relative ambulatory–fossorial function of each species using principal component analyses and mean percentile rank (MPR) analysis of the indices. Species within the Blarinellini–Blarinini clade exhibit a graded series of morphologies with four primary functional groupings that we classified as “ambulatory,” “intermediate,” “semifossorial,” and “fossorial.” To obtain a preliminary overview of evolution of locomotor modes in this group, we mapped MPRs on a composite phylogeny and examined the resulting patterns. That analysis revealed that the most recent common ancestor of the Blarinellini–Blarinini clade most likely had an intermediate or semifossorial locomotor morphology. Individual subclades subsequently evolved either more ambulatory or more fossorial morphologies. Hence, evolution of locomotor traits within this clade is complex. Multiple shifts in locomotor mode likely occurred, and no single directional tendency is apparent either among the major modes or in levels of complexity.
A Defense of the Phenomenological Account of Health and Illness
Authors: Svenaeus Fredrik 
Published: May 2019

AbstractA large slice of contemporary phenomenology of medicine has been devoted to developing an account of health and illness that proceeds from the first-person perspective when attempting to understand the ill person in contrast and connection to the third-person perspective on his/her diseased body. A proof that this phenomenological account of health and illness, represented by philosophers, such as Drew Leder, Kay Toombs, Havi Carel, Hans-Georg Gadamer, Kevin Aho, and Fredrik Svenaeus, is becoming increasingly influential in philosophy of medicine and medical ethics is the criticism of it that has been voiced in some recent studies. In this article, two such critical contributions, proceeding from radically different premises and backgrounds, are discussed: Jonathan Sholl’s naturalistic critique and Talia Welsh’s Nietzschean critique. The aim is to defend the phenomenological account and clear up misunderstandings about what it amounts to and what we should be able to expect from it.
Pilot clinical study of ascorbic acid treatment in cardiac catheterization
Authors: Sun Lue , Igarashi Tomonori , Tetsuka Ryoya , Li Yun-Shan , Kawasaki Yuya , Kawai Kazuaki , Hirakawa Haruhisa , Tsuboi Koji , Nakamura Asako J , Moritake Takashi 
Published: May 2019

AbstractClinical radiodiagnosis and radiotherapy sometimes induce tissue damage and/or increase the risk of cancer in patients. However, in radiodiagnosis, a reduction in the exposure dose causes a blockier image that is not acceptable for diagnosis. Approximately 70% of DNA damage is induced via reactive oxygen species and/or radicals created during X-ray irradiation. Therefore, treatment with anti-oxidants and/or radical scavengers is considered to be effective in achieving a good balance between image quality and damage. However, few studies have examined the effect of using radical scavengers to reduce radiation damage in the clinical setting. In this study, we administrated 20 mg/kg ascorbic acid (AA) to patients before cardiac catheterization (CC) for diagnostic purposes. We analyzed changes in the number of phosphorylated H2AX (γH2AX) foci (a marker of DNA double-strand breaks) in lymphocytes, red blood cell glutathione levels, blood cell counts, and biochemical parameters. Unfortunately, we did not find satisfactory evidence to show that AA treatment reduces γH2AX foci formation immediately after CC. AA treatment did, however, cause a higher reduced/oxidized glutathione ratio than in the control arm immediately after CC. This is a preliminary study, but this result suggests that reducing radiation damage in clinical practice can be achieved using a biological approach.
Validation of the dicentric chromosome assay for radiation biological dosimetry in South Korea
Authors: Lee Younghyun , Jin Young Woo , Wilkins Ruth C , Jang Seongjae 
Published: May 2019

Abstract
The dicentric chromosome assay (DCA) is a well-established biodosimetry test to estimate exposure to ionizing radiation. The Korea Institute of Radiological and Medical Sciences (KIRAMS) established a DCA protocol as a medical response to radiation emergencies in South Korea. To maintain its accuracy and performance, intercomparison exercises with Health Canada (HC) have been conducted; herein, we aimed to validate our capacity of DCA analysis based on those results. Blood samples irradiated at HC were shipped to KIRAMS to assess the irradiation dose to blinded samples using conventional DCA full scoring and triage-based techniques (conventional DCA scoring in triage mode and DCA QuickScan method). Actual doses fell within the 95% confidence intervals of dose estimates for 70–100% of the blinded samples in 2015–2018. All methods discriminated binary dose categories, reflecting clinical significance. This DCA can be used as a reliable radiation biodosimetry tool in preparation for radiation accidents in South Korea.