bluuebunny/crossref_metadata_2025_split huggingface dataset:
C3aR signaling and gliosis in response to neurodevelopmental damage in the cerebellum
Authors: Young Kevin G. , Yan Keqin , Picketts David J. 
Published: July 2019

AbstractBackgroundConditional ablation of theSmarca5gene in mice severely impairs the postnatal growth of the cerebellum and causes an ataxic phenotype. Comparative gene expression studies indicated that complement-related proteins were upregulated in the cerebellum ofSmarca5mutant mice. Complement proteins play critical roles within innate immune signaling pathways and, in the brain, are produced by glial cells under both normal and pathological conditions. The C3 complement protein-derived signaling peptide, C3a, has been implicated in contributing to both tissue damage and repair in conditions such as multiple sclerosis and stroke. Here, we investigated whether C3a receptor (C3aR) signaling promoted damage or repair in the developing cerebellum ofSmarca5mutant mice.MethodsBrain and cerebellum lysates from singleSmarca5conditional knockout (Smarca5cKO) mice,C3aR1KO mice, or double mutant mice were used for qRT-PCR and immunoblotting to assess the contribution of C3aR to theSmarca5cKO brain pathology. Immunohistochemistry was used to characterize alterations to astroglia and phagocyte cells in the developing cerebellum of each of the genotypes.ResultsC3aR signaling was observed to limit gliosis and promote granule neuron survival during postnatal cerebellar development. InSmarca5cKO mice, disorganized astroglia with increased GFAP expression develops concurrently with cerebellar granule neuron loss and phagocyte invasion over the first 10 days following birth. Potential ligand precursors of C3aR—VGF and C3—were found to have upregulated expression and/or altered processing during this time. Phagocytes (microglia and macrophages) in both the control andSmarca5mutant mice were the only cells observed to express C3aR. Loss of C3aR in theSmarca5cKO cerebellum resulted in increased numbers of apoptotic cells and early phagocyte invasion into the external granule cell layer, as well as an exacerbated disorganization of the Bergmann glia. The loss of C3aR expression also attenuated an increase in the expression of the efferocytosis-related protein, MerTK, whose transcript was upregulated ~ 2.5-fold in theSmarca5mutant cerebellum at P10.ConclusionsThis data indicates that C3aR can play an important role in limiting astrogliosis and regulating phagocyte phenotypes following developmental cell loss in the brain.
Systemic treatment for lung carcinoids: from bench to bedside
Authors: Torniai Mariangela , Scortichini Laura , Tronconi Francesca , Rubini Corrado , Morgese Francesca , Rinaldi Silvia , Mazzanti Paola , Berardi Rossana 
Published: July 2019

AbstractIn the huge spectrum of lung neuroendocrine neoplasms, typical and atypical carcinoids should be considered as a separate biological entity from poorly differentiated forms, harboring peculiar molecular alterations. Despite their indolent behavior, lung carcinoids correlate with a worse survival. To date, only limited therapeutic options are available and novel drugs are strongly needed. In this work, we extensively reviewed scientific literature exploring available therapeutic options, new molecular targets and future perspectives in the management of well differentiated neoplasms of bronchopulmonary tree. Systemic therapy represents the main option in advanced and unresectable disease; accepted choices are somatostatin analogs, peptide receptor radionuclide therapy, everolimus and chemotherapy. To date, an univocal treatment strategy has not been identified yet, thus tailored therapeutic algorithms should consider treatment efficacy as well as safety profiles. Several molecular alterations found in carcinoid tumors might act as molecular targets leading to development of new therapeutic options. Further studies are necessary to identify new potential “druggable” molecular targets in the selected subset of low‐grade lung carcinoids. Furthermore, evaluating the available therapies in more homogeneous population might improve their efficacy through a perfect tailoring of treatment options.
The lncRNA Hand2os1/Uph locus orchestrates heart development through regulation of precise expression of Hand2
Authors: Han Xue , Zhang Jiejie , Liu Yaxi , Fan Xiaoying , Ai Shanshan , Luo Yingjie , Li Xin , Jin Hengwei , Luo Sai , Zheng Hui , Yue Yanzhu , Chang Zai , Yang Zhongzhou , Tang Fuchou , He Aibin , Shen Xiaohua 
Published: July 2019

ABSTRACT
Exploration and dissection of potential actions and effects of long noncoding RNA (lncRNA) in animals remain challenging. Here, using multiple knockout mouse models and single cell RNA sequencing, we demonstrate that the divergent lncRNA Hand2os1/Uph has a key complex modulatory effect on the expression of its neighboring gene HAND2 and subsequently on heart development and function. Short deletion of the Hand2os1 promoter in mouse diminishes Hand2os1 transcription to ∼8-32%, but fails to affect HAND2 expression and yields no discernable heart phenotypes. Interestingly, full-length deletion of Hand2os1 in mouse causes moderate yet prevalent upregulation of HAND2 in hundreds of cardiac cells, leading to profound biological consequences, including dysregulated cardiac gene programs, congenital heart defects and perinatal lethality. We propose that the Hand2os1 locus dampens HAND2 expression to restrain cardiomyocyte proliferation, thereby orchestrating a balanced development of cardiac cell lineages. This study highlights the regulatory complexity of the lncRNA Hand2os1 on HAND2 expression, emphasizing the need for complementary genetic and single cell approaches to delineate the function and primary molecular effects of an lncRNA in animals.
Geostatistical analysis of Malawi’s changing malaria transmission from 2010 to 2017
Authors: Chipeta Michael Give , Giorgi Emanuele , Mategula Donnie , Macharia Peter M. , Ligomba Chimwemwe , Munyenyembe Alinane , Chirombo James , Gumbo Austin , Terlouw Dianne J. , Snow Robert W. , Kayange Michael 
Published: July 2019

Background: The prevalence of malaria infection in time and space provides important information on the likely sub-national epidemiology of malaria burdens and how this has changed following intervention. Model-based geostatitics (MBG) allow national malaria control programmes to leverage multiple data sources to provide predictions of malaria prevalance by district over time. These methods are used to explore the possible changes in malaria prevalance in Malawi from 2010 to 2017. Methods: Plasmodium falciparum parasite prevalence (PfPR) surveys undertaken in Malawi between 2000 and 2017 were assembled. A spatio-temporal geostatistical model was fitted to predict annual malaria risk for children aged 2–10 years (PfPR2–10) at 1×1 km spatial resolutions. Parameter estimation was carried out using the Monte Carlo maximum likelihood methods. Population-adjusted prevalence and populations at risk by district were calculated for 2010 and 2017 to inform malaria control program priority setting. Results: 2,237 surveys at 1,834 communities undertaken between 2000 and 2017 were identified, geo-coded and used within the MBG framework to predict district malaria prevalence properties for 2010 and 2017. Nationally, there was a 47.2% reduction in the mean modelled PfPR2-10 from 29.4% (95% confidence interval (CI) 26.6 to 32.3%) in 2010 to 15.2% (95% CI 13.3 to 18.0%) in 2017. Declining prevalence was not equal across the country, 25 of 27 districts showed a substantial decline ranging from a 3.3% reduction to 79% reduction. By 2017, 16% of Malawi’s population still lived in areas that support PfPR2-10 ≥ 25%. Conclusions: Malawi has made substantial progress in reducing the prevalence of malaria over the last seven years. However, Malawi remains in meso-endemic malaria transmission risk. To sustain the gains made and continue reducing the transmission further, universal control interventions need to be maintained at a national level.
La ambivalencia de los vínculos en el consumo: un análisis sociológico del caso Harley-Davidson
Authors: Barbeta Viñas Marc 
Published: July 2019

El artículo propone un análisis del sentido de las relaciones desarrolladas en el consumo de Harley-Davidson. Se discute, a partir de evidencias empíricas, las tesis acerca de los vínculos en el consumo de marcas como nuevas formas de vínculo social. Se presentan los resultados de una investigación cualitativa realizada con grupos de discusión y entrevistas abiertas. Los resultados revelan que las relaciones en el consumo de Harley mantienen una estructura significativa relacionada con aspectos culturales, identitarios y emocionales, y mediados por las posiciones sociales de los consumidores. Asimismo, profundizan en los procesos de fragmentación y particularismo de la vida social, en el espacio del consumo.
Новые данные по систематике и фауне Dolichopus subpennatus D'Assis Fonseca, 1976 и Dolichopus pennatus Meigen, 1824 (Dolichopodidae, Diptera)
Authors: Selivanova O.V. , Negrobov O.P. , Maslova O.O. 
Published: July 2019

Приводится дифференциальный диагноз между Dolichopus subpennatus и Dolichopus pennatus. Морфология гипопигия Dolichopus pennatus и Dolichopus subpennatus изучена впервые. Выделяются новые признаки по строению вентральных метаэпистерн, метанотума и морфологии гипопигия. Форма 3-го членика усиков не может быть использована для различения видов, ввиду внутривидовой изменчивости. Приводятся данные по фауне Dolichopus pennatus и Dolichopus subpennatus. Dolichopus pennatus впервые указывается Архангельской и Свердловской областей. Dolichopus subpennatus впервые указывается для Литвы, Молдавии, Украины, Ленинградской, Воронежской, Курской и Пермской областей РФ, а также для Алтая.
Отечественная историография сибирской одиссеи М.А. Бакунина (1857-1861 гг.): дискуссионный аспект
Authors: Должиков Вячеслав Александрович 
Published: July 2019

Представлен обзор отечественной научно-биографической литературы, посвященной четырехлетнему периоду деятельности в Сибири во время общенационального кризиса конца 1850-х — начала 1860-х гг. русского оппозиционного политика и мыслителя мировой величины Михаила Бакунина. Цель исследования состоит в том, чтобы восстановить его реальное место в общественной жизни пореформенной России. Для этого необходимо критически переоценить и преодолеть мифы историографии советского времени, которые мешают последовательной реконструкции событийного фона и контекста сибирской одиссеи Бакунина. В частности, опровергается миф о том, что в этот период М.А. Бакунин якобы находился в самоизоляции, причем добровольно отказался от любой общественной деятельности. Отмечен сомнительный характер происхождения этой версии, впервые сформулированной главным политическим оппонентом Бакунина в России — М.Н. Катковым, идеологом имперского охранительного консерватизма. Парадоксальным образом легенда была унаследована большевистской официозной историографией и в публикациях советского времени за редкими исключениями продолжала воспроизводиться до конца господства коммунистического режима.
Автор предлагает, во-первых, кардинально пересмотреть закрепившуюся в литературе схему историографического освещения «сибириады» Бакунина
и, во-вторых, переадресовать авторскую принадлежность некоторых памятников агитационной публицистики 1860-1861 гг., в том числе знаменитого «Письма» в редакцию «Колокола» (1860) с призывом «к топору». На основе текстологического контент-анализа лексики этого послания из Сибири формулируется вывод о том, что его настоящим автором в то время мог быть лишь самый близкий соратник Герцена и Огарева — Михаил Бакунин.
Воспроизводство населения Барнаула и Бийска в 1913-1927 гг.
Authors: Косыгина Светлана Валерьевна 
Published: July 2019

В работе впервые представлены абсолютные и относительные показатели роста численности горожан крупных сибирских городов Барнаула и Бийска. Были сделаны выводы, что в рамках периода коэффициенты рождаемости в Барнауле были сверхвысокими, кроме 1916 г. и 1922 г. В Бийске показатели рождаемости были еще выше. Коэффициенты смертности также были очень высокими, в 1917 г. и 1920 г. сравнимыми с коэффициентами рождаемости, а в 1915 г. в Барнауле, в 1921 г. и 1922 г. в обоих городах эти коэффициенты были выше коэффициентов рождаемости, что вызвало отрицательный естественный прирост. Аномальные колебания коэффициентов на протяжении периода свидетельствовали о демографической катастрофе. Показатели брачности в 1913-1920 гг. были стабильно средними, с 1921-1927 гг. интенсивность брачности резко выросла, средний показатель был выше 15%о. С 1923 г. тенденцией динамики населения стало снижение смертности как следствие высокой брачности, последовательное увеличение прироста населения.
Хронологические рамки исследования охватывают 1913-1927 гг. Выбор нижней границы объясняется возможностью сравнить довоенные «стабильные» коэффициенты с «нестабильными» послевоенными. Верхняя граница — 1927 г. — определяется резким увеличением коэффициента прироста населения в Барнауле. Цель исследования заключается в характеристике изменения режима воспроизводства населения в городах в указанный период. Выдвинуты задачи: на основе данных метрических книг и архивных документов определить изменение численности и режима воспроизводства горожан, выявить отличия в динамике населения Барнаула и Бийска.
SIMULATOR GENERATOR HARMONIK
Authors: Sasmoko Priyo 
Published: July 2019

Priyo Sasmoko, in this paper explain that the need of electric power recently progressively complex, not only the requirement of availability of electricity, but the quality of energy have become prime facie demand. Studies of electricity quality have been conducted by many experts, one of them is about harmonic. Harmonic represent waving current or tension which is tension distortion at electric power system mains so that can result unideal waveform. The study of harmonic required appliance or obyek which need to be checked. In this research Simulator Generator Harmonik is made a harmonic generator module which can deputize the appliance or obyek yielding harmonic with harmonic component and the THD which can be varried. This module works by dividing one cycle of mains become some slots so it can be got harmonic component as desired. To change the THD,a variation of linear load is used so that the ratio of non-linear load current can be varried. Keywords : Simulator, Harmonic component, THD
APLIKASI JAVA DAN MYSQL PADA SISTEM INFORMASI MINIMARKET
Authors: Sanjaya David Robby , Yuniarto Yuniarto 
Published: July 2019

David Robby Sanjaya, Yuniarto, in paper java and mysql application at minimarket information system explain that an endless human needs combined by their daily activities, made a lot of people reluctant to do shopping at a traditional market. Minimarket or supermarket that finally became a way out for this problem, because it had a good management system for organized the items and the transactions. Regulation of items and money at minimarket or supermarket require a good software. There are a lot of programming language that can be used for create this software, one of that is Java programming language. Java in this information system be used for create an interface to user while Mysql be used to manage a databases. Java programming language, Mysql, Netbeans and iReport are tools that applied to this Minimarket information system. Keywords: Minimarket Information System, iReport, Java, Mysql, Netbeans.
PEMBUATAN PULP DENGAN MEMANFAATKAN LIMBAH KULIT DURIAN (DURIO ZIBETHINUS MURR) DENGAN CAMPURAN (RESINA COLOPHONIUM) GUNA MENCEGAH DEGRADASI LINGKUNGAN
Authors: Kurniawan W Deddy Kurniawan W , Arifan Fahmi , Adim M. Dwi Khoirun 
Published: July 2019

Deddy Kurniawan W, Fahmi Arifan, M. Dwi Khoirun Adim, in this article explain that paper is one of the primary needs for humans today . High paper usage is resulting increased in production of paper . On the other hand, paper which are usually made ​​from cellulose and hemi-cellulose in wood can result environmental degradation , due to the use of wood and tree felling leads to long-term basis that can increase the temperature of the earth surface ( global warming) . Durian is relatively abundant in Indonesia , durian shell contains high cellulose ( 50-60 % ) and lignin content ( 5 %), also a low starch content ( 5 % ) . Durian shell wastes containing fibre with dimensions of length and fiber thick wall that be able to bind well when given a synthetic adhesive or an adhesive mineral . Pulp which is produced from durian shell waste in experiments were 1 , 2 , 3 and 4, have a value of α - cellulose content of 35 % , 45 % , 27.7 % , 37.5 % and 57.6 %, respectively. When yield value of 49.2 % , 66.8 % and 48.2 % respectively. Keywords: pulp, durian, gondorukem, digester
APLIKASI SMART CARD PADA METERAN AIR DIGITAL PRABAYAR BERBASIS ARDUINO MEGA 2560
Authors: Rafik Adhila , Yuniarto Yuniarto 
Published: July 2019

Adhila Rafik, Yuniarto, in paper smart card application in prepaid digital water meter based on arduino mega 2560 explain that water is a daily necessity, to get a decent clean water to be used, we can use the services of the service taps to get water, but the post-pay payment method used taps raises its own problems, namely the problem of payment arrears. To resolve the issue of payment methods can be converted to a prepaid system, so the use of water dilakuakn after the user makes a payment in advance, many prepaid methods, one of which is the smart card is a plastic card in which there is a microcontroller chip that makes it possible to encrypt the data that there didalamya so not just anyone can read and menulisa data into the card, the use of smart cards as a payment method for a digital prepaid water meter taps, can overcome the problem of payment arrears. Because the use of RFID technology allows the User just close the smart card reader to its user. Keywords: smart cards, prepaid, RFID
EVALUASI KESELAMATAN DAN KESEHATAN KERJA PADA PRAKTIKUM PERANCANGAN TEKNIK INDUSTRI II MENGGUNAKAN METODE JOB SAFETY ANALYSIS
Authors: Sulistiyowati Rina , Suhardi Bambang , Pujiyanto Eko 
Published: July 2019

Praktikum Perancangan Teknik Industri II(PPTI II) merupakan bagian dari praktikum terintegrasi di Program Studi Teknik Industri UNS yang melakukan kegiatan manufakturdaribahan baku sampai menjadi produk. Prosesmanufaktur menggunakanmesin yang menimbulkan suara bising yang belum sesuai dengan Keselamatan dan Kesehatan Kerja(K3).Penelitian ini bertujuan untuk mengevaluasiK3 pada PPTI IIuntuk mengantisipasi terjadi kecelakaan kerja. Analisis K3menggunakan metode Job Safety Analysis(JSA)denganmengidentifikasi dan menganalisis potensi risiko kecelakaan kerja. Metode penelitian ini dilakukan dengan pengukuran kebisingan dan suhuserta melakukan wawancara terstruktur kepada praktikan. Pengukuran yang dilakukan adalah pengukuran kebisingan dan suhu dalam laboratorium dan untuk memperkuat hasil pengukuran dilakukan wawancara terstruktur terhadap 20 praktikan dari total praktikan yang berjumlah 71 mahasiswakemudian melakukan analisis menggunakan JSA. Hasil penilaian tingkat risikodiketahui bahwa 66,67% potensi risiko paling tinggi adalah karena kebisingan diatas Nilai Ambang Batas. Abstract [Title:Work Safety and Health Evaluation on Industrial Engineering Design Practicum II using Job Safety Analysis Method]Industrial Engineering Design Practicum II (IEDP II) is part of an integrated practicum in the UNS Industrial Engineering Study Program that carry out manufacturing activities from raw materials to products. The manufacturing process usesmachines that cause noise that are not in accordance with Occupational Safety and Health (OHS). This study consisted to evaluate OHS in IEDP II to anticipate workplace accidents. OHS analysis uses the Job Safety Analysis Method by identifying and analyzingthe potential risk of workplace accidents. The method of this research is carried out by measuring noise and temperature and conducting structured interviews with practitioners.Measurements made were measurements of noise and temperature in the laboratory and to strengthen the results of measurements conducted structuredinterviews of 20 practitioners from a total of 71 students who then analyzed using JSA. The results of the risk level assessment revealed that 66.67% of the highest risk potential was due to noise.Keywords:JobSafety Analysis;Occupational Safety and Health; Industrial Engineering Design Practicum II
Persuasi dalam Wacana Iklan
Authors: Astuti Sri Puji 
Published: July 2019

Advertisement is a marketing tool that helps selling goods, providing services, and ideas through certain way in the form of persuasive information. How the persuasion strategy used the advertiser in other to be able to draw attention of potential customers is discussed in this paper. This research data is in the form of advertising discourse. The data used in this study comes from the advertising discourse of online. In the data collection activities used was the observation method or refer method namely listening the use of language in the advertising discourse online. Data was selected according to the research needs. Data were analyzed by using content analysis. The results showed that there were two ways of advertisers persuading prospective customers was persuasion implicitly, and explicitly.
Aggregation-promoting conditions necessary to create the complexes by acylphosphatase from the hyperthermophile Sulfolobus solfataricus
Authors: Banach Mateusz , Wiśniowski Zdzisław , Ptak Magdalena , Roterman Irena 
Published: July 2019

Abstract
The structural transition from the globular to the amyloid form of proteins requires aggregation-promoting conditions. The protein example of this category is acylphosphatase from the hyperthermophile Sulfolobus solfataricus. This protein represents a structure with a well-defined hydrophobic core. This is why the complexation (including oligomerization) of this protein is of low probability. The chain fragment participating in aggregation in comparison to the status with respect to the fuzzy oil drop model is discussed in this paper.
Comparison of proteomic profiles of the phaeophyte Saccharina japonica thalli proximal to and beneath the front of epiphytic hydrozoan colonies against healthy tissue
Authors: Getachew Paulos , Nam Bo-Hye , Hong Yong-Ki 
Published: July 2019

Abstract
The stoloniferous hydrozoan Obelia geniculata commonly colonizes macroalgae such as Saccharina japonica. Each Obelia colony consists of thread-like hydrorhizae attached to the seaweed thallus. The early signaling proteins of epiphytic contamination can be identified using proteomics. To isolate these early signals, parts of the thallus proximal to the hydrozoans were separated from beneath the colony front and from healthy tissue. From the proteomic profiles of S. japonica, we detected 110 protein spots from tissue proximal to hydrozoan colonies (56 increased, 53 decreased, and 1 unchanged in expression relative to healthy tissue) and 133 spots from tissue at the colony front (67 increased, 60 decreased, and 6 unchanged in expression). Of the proteins with increased and decreased expression, SIPA1L1 and actin increased strongly only in the proximal tissues, while NEK2 kinase decreased. CIPK20 and SIPA1L2 increased markedly in both the colony-front and proximal tissues, while CaMK2N2 and GK25369 decreased in both tissues. ATPase β, ADA, kinesin, and HECT domain proteins increased only in the colony-front tissues. Among them, SIPA1L2 increased strongly in both the thallus tissues proximal to the hydrozoans and those beneath the colony front, but was not expressed in response to bryozoan infection.