bluuebunny/crossref_metadata_2025_split huggingface dataset:
White‐Light Emission from Dual‐Way Photon Energy Conversion in a Dye‐Encapsulated Metal–Organic Framework
Authors: Wang Zheng , Zhu Cheng‐Yi , Mo Jun‐Ting , Fu Peng‐Yan , Zhao Yan‐Wu , Yin Shao‐Yun , Jiang Ji‐Jun , Pan Mei , Su Cheng‐Yong 
Published: May 2019

AbstractThe design of white‐light phosphors is attractive in solid‐state lighting (SSL) and related fields. A new strategy in obtaining white light emission (WLE) from dual‐way photon energy conversion in a series of dye@MOF (LIFM‐WZ‐6) systems is presented. Besides the traditional UV‐excited one‐photon absorption (OPA) pathway, white‐light modulation can also be gained from the combination of NIR‐excited green and red emissions of MOF backbone and encapsulated dyes via two‐photon absorption (TPA) pathway. As a result, down‐conversion OPA white light was obtained for RhB+@LIFM‐WZ‐6 (0.1 wt %), BR‐2+@LIFM‐WZ‐6 (2 wt %), and APFG+@LIFM‐WZ‐6 (0.1 wt %) samples under 365 nm excitation. RhB+@LIFM‐WZ‐6 (0.05 wt %), BR‐2+@LIFM‐WZ‐6 (1 wt %) and APFG+@LIFM‐WZ‐6 (0.05 wt %) exhibit up‐conversion TPA white light under the excitation of 800, 790, and 730 nm, respectively. This new WLE generation strategy combines different photon energy conversion mechanisms together.
Inverse‐Electron‐Demand Palladium‐Catalyzed Asymmetric [4+2] Cycloadditions Enabled by Chiral P,S‐Ligand and Hydrogen Bonding
Authors: Wang Ya‐Ni , Xiong Qin , Lu Liang‐Qiu , Zhang Qun‐Liang , Wang Ying , Lan Yu , Xiao Wen‐Jing 
Published: May 2019

AbstractCatalytic asymmetric cycloadditions of ambident Pd‐containing dipolar species with nucleophilic dipolarophiles, namely, inverse‐electron‐demand cycloadditions, are challenging and underdeveloped. Possibly, the inherent linear selectivity of Pd‐catalyzed intermolecular allylations and the lack of efficient chiral ligands are responsible for this limitation. Herein, two cycloadditions of such intermediates with deconjugated butenolides and azlactones were accomplished by using a novel chiral hybrid P,S‐ligand and hydrogen bonding. By doing so, highly functionalized, optically active dihydroquinol‐2‐ones were produced with generally high reaction efficiencies and selectivities. Preliminary DFT calculations were performed to explain the high enantio‐ and diastereoselectivities.
Unprecedented isolation of a dinuclear tin (II) complex stabilized by pyridine‐2,6‐dimethanol: structure, DFT and in vitro screening of cytotoxic properties
Authors: I. Mantasha , Raza Md Kausar , Shahid M. , Ansari Azaj , Ahmad Musheer , Khan Ishaat M. 
Published: May 2019

In this work, we report a novel dinuclear Sn (II) complex, [Sn2(Hpdm)2(H2O)6] 2H2O 2Cl (1) (H2pdm = pyridine‐2,6‐dimethanol), which has been crystallized out and characterized by elemental analysis, FTIR, 1H and 13C NMR, single crystal X‐ray studies and Density Functional Theory (DFT) analysis. X‐ray structure of 1 has confirmed it to be a dinuclear alkoxo‐bridged Sn (II) species where each metal adopts a seven coordinate distorted pentagonal bipyramidal (pbp) geometry. This is the first hepta‐coordinated Sn (II) complex ever isolated apart from already reported stannylenes. Spin density plots from DFT support the +2 oxidation state of each tin metal. Hirshfeld surface analysis reveals the presence of various H‐bonding interactions in the molecule and molecular docking results along with DFT confirm higher binding affinity of the present complex towards DNA. Moreover, the complex exhibits promising anticancer activities against HeLa and A549 cancer cell lines.
Morphological evaluation and phase behavior of PVDF/PEO blends in the presence of graphene nanoplatelets through rheological measurements
Authors: Mohamadi Mahboube , Papila Melih , Garmabi Hamid , Gohari Bajestani Zahra 
Published: May 2019

ABSTRACTIn this study, graphene nanoplatelets (GNPs) were incorporated into poly(vinylidene fluoride) (PVDF), poly(ethylene oxide) (PEO), and PVDF/PEO blends using solution casting method in order to achieve binary and ternary polymer nanocomposites. The focus of the work is on the compatibilizing effects of the GNPs on partially miscible PVDF/PEO blends. X‐ray diffraction method, rheological measurements, scanning electron microscopy (SEM), and atomic force microscopy observations enabled us to track the dispersion state and localization of the graphene nanosheets in the nanocomposites. The results exhibited that the nanoplatelets were preferentially distributed through the PVDF phase and/or at the interface of the PVDF/PEO phases. Evaluation of the wetting parameter for the PVDF/PEO/GNPs nanocomposite also verified better affinity of the selected nanofiller with the PVDF component. Extend of the miscibility in the nanocomposites was studied by a well‐known rheological method. A tangible increment in binodal (Tb) and spinodal (Ts) decomposition temperatures by addition of a very low content of the GNPs (0.5 wt %) revealed well‐defined compatibilization effects of the graphene on this binary polymer blend. SEM images at different temperatures confirmed the rheologically determined liquid–liquid phase diagram. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 48017.
Pharmacokinetics of cligosiban in dog plasma after oral administration by liquid chromatography electrospray ionization tandem mass spectrometry
Authors: Xi Wang , Zou Qiaogen , Ouyang Pingkai 
Published: May 2019

AbstractIn this study, a simple and reliable liquid chromatography coupled with Q‐Exactive‐Orbitrap–MS was developed and validated for detecting and quantifying cligosiban and its metabolites in dog plasma after oral administration. The plasma samples were pretreated with acetonitrile and separated on a Diamonsil C18 column (4.6 × 100 mm, i.d. 3 μm) with 0.1% formic acid in water and acetonitrile as mobile phase. The method was validated according to the guidance of the US Food and Drug Administration. The assay was linear over the tested concentration ranges with coefficients of correlation >0.995. The extraction recovery was >83.23% with RSD <15%. Precision was <9.31% and accuracy ranged from −4.40 to 10.20%. The method was free of matrix effects. Under the conditions used, four metabolites were detected and their identities were identified by accurate masses and fragment ions. M1 and M3 were further confirmed by reference standards. The biotransformation pathways included demethylation and glucuronidation. The validated method was further applied to quantify cligosiban, M1 and M3 in dog plasma. After oral administration, cligosiban was detectable in dog plasma and reached the maximum concentration at ~1.67 ± 0.58 h post‐dose. It was rapidly eliminated with a half‐life of 3.48 ± 0.80 h. M1 showed high plasma exposure with its area under the curve being 23.31% of that of cligosiban.
Differences between physicians' and nurse practitioners' viewpoints on reasons for clozapine underprescription
Authors: Okhuijsen‐Pfeifer Cynthia , Cohen Dan , Bogers Jan P. A. M. , de Vos Cato M. H. , Huijsman Elianne A. H. , Kahn René S. , Luykx Jurjen J. 
Published: May 2019

AbstractIntroductionClozapine (CLZ) is the only proven effective therapy for treatment‐resistant schizophrenia, but it is underutilized across the globe. Previous findings suggest a lack of experience with CLZ prescription and concerns about CLZ's pharmacological characteristics are the prime reasons for CLZ underutilization. To our knowledge, it is currently unknown whether the reasons for underutilization and suggested solutions differ between physicians and nurse practitioners. Such differences are important as nurse practitioners are becoming increasingly involved in prescribing CLZ.MethodsTo examine to what degree physicians and nurse practitioners differ with regard to their take on reasons for CLZ underutilization and suggested solutions, an online questionnaire was distributed to physicians and nurse practitioners. The primary outcome was to compare the patient‐related and prescriber‐related reasons for CLZ underprescription between physicians and nurse practitioners, while secondary outcome measures included the potential solutions to prevent this underprescription.ResultsPhysicians (N = 112) and nurse practitioners (N = 41) agreed that the two most common reasons for underprescription (patient‐related and prescriber‐related) were refusal to undergo regular blood tests and side‐effect concerns. They also agreed that the third most common prescriber‐related reason was medical complications. Physicians rated patients' unwillingness to switch medication as the third most common reason for CLZ underprescription, whereas nurse practitioners rated refusal to undergo baseline bloodtests as the third most common reason. The solutions to reduce underprescription largely corresponded between both groups.ConclusionsWe conclude that slight differences exist between physicians' and nurse practitioners' viewpoints on patient‐related and prescriber‐related reasons for CLZ underprescription. Future research projects should involve patients to elucidate whether the patient‐related factors put forward by prescribers align with the patients' opinions.
Response to pneumococcal vaccination in multiple myeloma
Authors: Renaud Loïc , Schraen Susanna , Fouquet Guillemette , Guidez Stephanie , Demarquette Hélène , Nudel Morgane , Cayssials Emilie , Bories Claire , Herbaux Charles , Systchenko Thomas , Faucompré Jean‐Luc , Machet Antoine , Sabirou Florence , Levy Antony , Bobin Arthur , Richez Valentine , Moya Niels , Gruchet Cécile , Desmier Deborah , van de Wyngaert Zoe , Carpentier Benjamin , Manier Salomon , Facon Thierry , Harding Stephen , Leleu Xavier 
Published: May 2019

AbstractBackgroundStreptococcus pneumoniae infection causes morbidity and mortality in multiple myeloma patients. Pneumococcal vaccination is commonly given to immunocompromised myeloma patients; however response data are sparse. Here, we present longitudinal response data to pneumococcal vaccination in multiple myeloma patients.MethodTwenty‐eight multiple myeloma patients were included, 25 of whom were newly diagnosed. All the patients received two vaccines Prevnar13® and Pneumo23®. Serotype‐specific IgG was measured by ELISA for all 23 vaccine serotypes at baseline, and then sequentially at different time points postvaccination until treatment ended. Response to vaccination is available for 20 patients. The primary endpoint was the incidence rate of patients who obtained an isotype response serum concentration after vaccination. Secondary endpoints included detailed isotype increase, time to first increase, further assessment of a decreased anti‐pneumococcal serum concentrations following treatment including autologous stem cell transplantation (ASCT), rate of infection with a special attention to pneumococcal infection.ResultsThe median age was 66 years and the male to female ratio was 0.6. Anti‐pneumococcal capsular polysaccharide (anti‐PCP23) IgG, IgG2, IgA, and IgM responses were detected within 1 week postvaccination. Response to at least one subtype of antibody was obtained in 85% (n = 17) of patients, for at least two subtypes in 65% (n = 13), for at least three subtypes in 55% (n = 11), and 2 patients responded to all four subtypes. The median increase in the concentration of anti‐PCP23 isotypes was threefold following vaccination, with the highest increase observed when Pneumo23® was given more than 30 days after Prevnar13®. The anti‐pneumococcal geometric mean concentration decreased significantly for all subtypes over time independently of treatment approaches.ConclusionMyeloma has the ability to demonstrate a response to pneumococcal vaccine, independently of preexisting hypogammaglobulinemia and possibly of treatment‐induced immunodepression. We also observed a drop in the serum response overtime and following autologous transplantation. Further studies in larger sample are needed to understand the benefit of vaccination strategies in these patients.
Dialectical behaviour therapy and 12‐step programmes for substance use disorder: A systematic review and meta‐analysis
Authors: Giannelli Ezechiele , Gold Christian , Bieleninik Lucja , Ghetti Claire , Gelo Omar C. G. 
Published: May 2019

AbstractBackgroundResearch on dialectical behaviour therapy (DBT) or 12‐step programmes has shown inconclusive results; no systematic review has directly compared the two.ObjectivesThe goals of this meta‐analytic review were to assess if DBT is more effective than treatment as usual (TAU) and if DBT is more effective than 12‐step programmes (including twelve‐step facilitation [TSF] and self‐help groups like Alcoholics Anonymous) for substance use disorder (SUD).MethodsWe searched for randomised controlled trials (RCTs) and extracted data on the following outcomes: reduction in substance use, retention in treatment, severity of substance dependence/abuse and severity of mental health symptoms. Studies involved adult (>18 years) women with SUD, according to DSM‐5 or the equivalent diagnoses in DSM‐IV. Three RCTs met the inclusion criteria and contained appropriate data for meta‐analysis (75 participants).ResultsNo significant effects of DBT have been found compared to 12‐step programmes. Comparing DBT with TAU, we found a beneficial short‐term (1 RCT, n = 12, SMD = −0.84; 95% CI [−1.64, −0.04]) and long‐term (2 RCTs, n = 29, SMD = −1.26; 95% CI [−2.13, −0.40]) effect of DBT on severity of substance use.ConclusionsDespite the limited evidence of the present review, contextual evidence supports DBT and 12‐step programmes. RCTs with larger sample sizes are needed to better elucidate the impact of both treatments on SUD and facilitate the comparison between DBT and 12 steps programmes.
Not just who you are, but who you were before: Social identification, identity incompatibility, and performance‐undermining learning behaviour in higher education
Authors: Smyth Lillian , Mavor Kenneth I. , Gray Louie R. 
Published: May 2019

AbstractThe current study builds on links between academic social identification and learning behaviours and extends these models by also considering the level of compatibility between the student identity and the pre‐existing self‐concept. This is a crucial extension, in the context of broadening access to higher education and fostering belonging and learning in nontraditional students. Further, where previous work focused on learning behaviours that enhance performance (often learning approaches), we also consider performance‐undermining behaviours (self‐handicapping and procrastination). These effects are explored in survey responses from an undergraduate student sample (N = 121) from UK and broader European samples. Participants were predominantly female (69%) and native English speakers (87%). Three models of the relationships between these variables were tested using Mplus. Results indicate that performance‐undermining behaviours are predicted by identity incompatibility, but not identification level; deep learning approaches are predicted by identification level, but not identity incompatibility. This provides first evidence that identity incompatibility is not just a moderator of the identification‐learning relationships but, in fact, a separate identity process for consideration. We also present initial evidence for a mediation model, where in the identity variables are related to procrastination and self‐handicapping via learning approaches.
Very Bright Phycoerythrobilin Chromophore for Fluorescence Biolabeling
Authors: Hou Ya‐Nan , Ding Wen‐Long , Hu Ji‐Ling , Jiang Xiang‐Xiang , Tan Zi‐Zhu , Zhao Kai‐Hong 
Published: May 2019

AbstractBiliproteins have extended the spectral range of fluorescent proteins into the far‐red (FR) and near‐infrared (NIR) regions. These FR and NIR fluorescent proteins are suitable for the bioimaging of mammalian tissues and are indispensable for multiplex labeling. Their application, however, presents considerable challenges in increasing their brightness, while maintaining emission in FR regions and oligomerization of monomers. Two fluorescent biliprotein triads, termed BDFP1.2/1.6:3.3:1.2/1.6, are reported. In mammalian cells, these triads not only have extremely high brightness in the FR region, but also have monomeric oligomerization. The BDFP1.2 and BDFP1.6 domains covalently bind to biliverdin, which is accessible in most cells. The BDFP3.3 domain noncovalently binds phycoerythrobilin that is added externally. A new method of replacing phycoerythrobilin with proteolytically digested BDFP3.3 facilitates this labeling. BDFP3.3 has a very high fluorescence quantum yield of 66 %, with maximal absorbance at λ=608 nm and fluorescence at λ=619 nm. In BDFP1.2/1.6:3.3:1.2/1.6, the excitation energy that is absorbed in the red region by phycoerythrobilin in the BDFP3.3 domain is transferred to biliverdin in the two BDFP1.2 or BDFP1.6 domains and fluoresces at λ≈670 nm. The combination of BDFP3.3 and BDFP1.2/1.6:3.3:1.2/1.6 can realize dual‐color labeling. Labeling various proteins by fusion to these new fluorescent biliproteins is demonstrated in prokaryotic and mammalian cells.
Selective Aerobic Oxidation of Lactate to Pyruvate Catalyzed by Vanadium‐Nitrogen‐Doped Carbon Nanosheets
Authors: Zhang Wei , Oulego Paula , Slot Thierry K. , Rothenberg Gadi , Shiju N. Raveendran 
Published: May 2019

AbstractThe catalytic oxidative dehydrogenation of lactates with molecular oxygen is a promising yet challenging route for producing high‐value pyruvates from biomass. Here we report a simple synthetic strategy for preparing nitrogen‐doped carbon nanosheets (NCNs) starting from two abundant precursors, cheap melamine and glucose, and using a simple thermal‐annealing process. The resulting NCNs feature numerous edges and holes for anchoring vanadium oxides (V‐NCNs). This creates cooperative catalytic sites that boost the catalytic oxidation of ethyl lactate to ethyl pyruvate. Additionally, we systematically studied the surface nitrogen species of NCNs by varying the pyrolysis temperature, and found that the active pyridinic N‐oxide species formed in a high thermal‐annealing treatment, acting synergistically with vanadium active sites in converting ethyl lactate with oxygen into ethyl pyruvate under mild conditions.
Atypical cytological changes mimicking SIL of the uterine cervix in allogenic hematopoietic stem cell transplantation recipients treated with busulfan
Authors: Saco Adela , Alòs Silvia , Esteve Roser , Suárez‐Lledó María , Martínez Carmen , Perez Francisco M. , Vega Naiara , Martí Cristina , Torne Aureli , Ordi Jaume , del Pino Marta 
Published: May 2019

BackgroundAllogenic hematopoietic stem cell transplantation (allo‐HSCT) is a common procedure in hematological disorders and is preceded by a conditioning regimen that usually includes busulfan. The immunosuppression caused by the conditioning regimen and graft‐versus‐host disease prophylaxis is associated with human papillomavirus (HPV) persistence and, consequently, with an increased risk of cervical cancer (CC) and squamous intraepithelial lesions (SILs)—the precursors of CC. A gynecological check‐up that includes CC screening is recommended in these patients.MethodsAll female recipients of allo‐HSCT undergo routine gynecological check‐up that includes CC screening. Cervical samples were obtained for liquid‐based cytology and HPV testing. Cytology smears were stained with the Papanicolaou (Pap) technique. A colposcopy evaluation was performed if any abnormal result in the screening tests was obtained.ResultsAmong 15 women undergoing gynecological examination at 1 year after allo‐HSCT who had received a conditioning regimen that included busulfan, 4 (26.7%) showed atypical squamous cells in the Pap smear, suggesting high‐grade SIL. The abnormalities were identified from 136 to 271 days after allo‐HSCT. In all cases, HPV testing was negative, and colposcopy examination was normal. The cytological abnormalities regressed in 3 of the women after 1 year but persisted in 1 woman at day 382 after allo‐HSCT.ConclusionsTreatment‐related atypia mimicking SIL is a common finding in allo‐HSCT recipients who have received busulfan, particularly in the first year after the procedure. However, atypical changes may persist for more than 1 year. Clinical information, HPV testing, and colposcopy examination are critical to prevent misdiagnosis and overtreatment in these patients.
Theoretical Identification of the Factors Governing the Reactivity of C−H Bond Activation by Non‐Heme Iron(IV)‐Oxo Complexes
Authors: Roy Lisa 
Published: May 2019

AbstractSelective functionalization of C−H bonds provides a straightforward approach to a large variety of well‐defined derivatives. High‐valent mononuclear iron(IV)‐oxo complexes are proposed to carry out these C−H activation reactions in enzymes or in biomimetic syntheses. In this Minireview, we aim to highlight the features that delineate the distinct reactivity of non‐heme oxo‐iron(IV) motifs to cleave strong C−H bonds in hydrocarbons, primarily focusing on the hydrogen atom transfer (HAT) process. We describe how the structural and electronic properties of supporting ligands modulate the oxidative property of the iron(IV)‐oxo complexes. Furthermore, we highlight the decisive role played by spin‐state in these biomimetic reactions. We also discuss how tunneling and external perturbations like electric field influence the transfer of hydrogen atoms. Lastly, we emphasize how computations could work as a practical guide to sketch and develop synthetic models with greater efficacy.
Quantifying the Dynamics of Hematopoiesis by In Vivo IdU Pulse‐Chase, Mass Cytometry, and Mathematical Modeling
Authors: Erez Amir , Mukherjee Ratnadeep , Altan‐Bonnet Grégoire 
Published: May 2019

AbstractWe present a new method to directly quantify the dynamics of differentiation of multiple cellular subsets in unperturbed mice. We combine a pulse‐chase protocol of 5‐iodo‐2′‐deoxyuridine (IdU) injections with subsequent analysis by mass cytometry (CyTOF) and mathematical modeling of the IdU dynamics. Measurements by CyTOF allow for a wide range of cells to be analyzed at once, due to the availability of a large staining panel without the complication of fluorescence spillover. These are also compatible with direct detection of integrated iodine signal, with minimal impact on immunophenotyping based on the surface markers. Mathematical modeling beyond a binary classification of surface marker abundance allows for a continuum of cellular states as the cells transition from one state to another. Thus, we present a complete and robust method for directly quantifying differentiation at the systemic level, allowing for system‐wide comparisons between different mouse strains and/or experimental conditions. Published 2019. This article is a U.S. Government work and is in the public domain in the USA.