bluuebunny/crossref_metadata_2025_split huggingface dataset:
Topical Mupirocin Treatment Reduces Interferon and Myeloid Signatures in Cutaneous Lupus Erythematous Lesions Through Targeting of Staphyloccal Species
Authors: Abernathy‐Close Lisa , Mears Joseph , Billi Allison C. , Sirobhushanam Sirisha , Berthier Celine , Lu Annie , Zhang Zeran , Hurst Amy , Gudjonsson Johann E. , Kahlenberg J. Michelle 
Published: December 2024

ObjectiveCutaneous lupus erythematosus (CLE) is an inflammatory skin manifestation of systemic lupus erythematosus. Type I interferons (IFNs) promote inflammatory responses and are elevated in CLE lesions. We recently reported that CLE lesions are frequently colonized with Staphylococcus aureus. Here, we follow up via a proof‐of‐concept study to investigate whether type I IFN and inflammatory gene signatures in CLE lesions can be modulated with mupirocin, a topical antibiotic treatment against S aureus–mediated skin infections.MethodsParticipants with active CLE lesions (n = 12) were recruited and randomized into a week of topical treatment with either 2% mupirocin or petroleum jelly vehicle. Paired samples were collected before and after seven days of treatment to assess microbial lesional skin responses. Microbial samples from nares and lesional skin were used to determine baseline and posttreatment Staphylococcus abundance and microbial community profiles by 16S ribosomal RNA gene sequencing. Inflammatory responses were evaluated by bulk RNA sequencing of lesional skin biopsies.ResultsWe identified 173 differentially expressed genes in CLE lesions after topical mupirocin treatment. Decreased lesional Staphylococcus burden correlated with decreased IFN pathway signaling and inflammatory gene expression and barrier dysfunction. Interestingly, mupirocin treatment lowered skin monocyte levels, and this mupirocin‐associated depletion of monocytes correlated with decreased inflammatory gene expression.ConclusionMupirocin treatment decreased lesional Staphylococcus, and this correlated with decreased IFN signaling and inflammatory gene expression. This study suggests a topical antibiotic could be employed to decrease lupus skin inflammation and type I IFN responses by reducing Staphylococcus colonization.image
Design and analysis of H∞$$ {H}_{\infty } $$ control strategies with dynamic event‐triggered schemes and quantizer in the presence of hybrid attacks
Authors: Zhan Heng , Wu Jie , Cheng Lingli , Zhan Xisheng , Yan Huaicheng 
Published: December 2024

AbstractThis study explores the resilience of networked control systems (NCSs) against hybrid attacks, focusing on enhancing their
performance. To mitigate excessive data transmission, the article introduces dynamic event‐triggered schemes and quantizer within the sensor‐to‐observer communication channel. The network environment is susceptible to various attacks, including denial‐of‐service (DoS) attacks and deception attacks. An augmented system model is formulated, and through the application of Lyapunov stability theory, conditions for ensuring the asymptotic stability of the system are established. The collaborative design of quantizer parameters, controller gain, and event‐triggered thresholds is achieved by solving linear matrix inequalities. Simulation‐based theoretical models have effectively demonstrated the reduction of the impact of network intrusions on NCSs, validating the proposed approach.
Orts‐ und Zeitangaben‐Harmonisierung zwischen Strahlungsdaten und Simulationssoftware
Authors: Vukadinovic Mario , Maas Anton 
Published: December 2024

AbstractDiese Untersuchung fokussiert auf die Herausforderungen, die sich bei der Verarbeitung von Klimadaten durch Simulationssoftware ergeben. Ein zentraler Aspekt besteht darin, die unterschiedlichen Definitionen von Ort und Zeit zu berücksichtigen, wenn Testreferenzjahre (TRY) verschiedener Datenreihen verwendet werden. Dabei werden die Definitionen und Angaben der Zeiten miteinander verglichen und bewertet. Die Untersuchung erfolgt exemplarisch für die TRY des Deutschen Wetterdienstes (DWD), ist jedoch auch auf andere Klimadatengeber übertragbar. Es wird dargestellt, wie Zeitdefinitionen die Umrechnung von direkter und diffuser Strahlung beeinflussen und dass für simulative Berechnungen präzise und eindeutige Zeiten für bestimmte Orte unerlässlich sind. In diesem Kontext werden die Definitionen in den DWD‐TRY 2010, 2015 und 2045 beleuchtet. Es wird ersichtlich, dass Definitionen sogar innerhalb einheitlicher Datenreihen Inkonsistenzen aufweisen. Zudem wird erörtert, dass verschiedene Simulationssoftwares unterschiedlich mit diesen Definitionen umgehen. Abschließend betont die Analyse die Notwendigkeit einer genauen Übereinstimmung zwischen dem Standort des Gebäudes und dem Standort des Klimadatensatzes sowie die Bedeutung einer einheitlichen Zeitdefinition über verschiedene TRY‐Datenreihen hinweg. Eine präzise Erfassung der Strahlungsdaten ist für korrekte Anwendungen unerlässlich und ermöglicht die genaue Aufteilung der Strahlungswerte zwischen Osten und Westen.
Thermische Bauteilaktivierung: Ein Gamechanger der Energiewende für die Gebäudesanierung
Authors: Weiß Dirk , Tribulowski Katja , Kotte Luisa , Wicke Monika , Grunewald John 
Published: December 2024

AbstractDiese Studie analysiert den Einfluss der thermischen Speichermasse auf die Energieeffizienz und das Lastmanagement in unterschiedlichen Gebäudesanierungsvarianten: ein Wärmedämmverbundsystem (WDVS) mit bestehenden Heizkörpern, WDVS in Kombination mit einer Flächenheizung und eine außenliegende Fassadenkonditionierung durch das Aktive Dämmheizkühlsystem (AktivDHKS). Ziel der Untersuchung ist es, das Potenzial dieser Sanierungsansätze zur Verbesserung der Lastverschiebung (Load‐Shifting) und zur Reduktion von Lastspitzen (Peak‐Shaving) im Stromnetz zu bewerten. Durch den Einsatz von thermischen Simulationen werden die dynamischen Reaktionen der Gebäudehüllen auf externe und interne Lasten sowie deren Interaktionen mit dem Energieversorgungssystem evaluiert. Die vorläufigen Ergebnisse deuten darauf hin, dass insbesondere das AktivDHKS durch seine direkte Aktivierung der thermischen Masse erheblich zur Stabilisierung des Stromnetzes beitragen kann. Diese Erkenntnisse bieten wertvolle Impulse für die Entwicklung nachhaltiger Sanierungsstrategien, die sowohl ökonomische als auch ökologische Vorteile bieten und unterstützen somit die Realisierung der Ziele der Energiewende.
Simulativer Vergleich der thermischen Bedarfsabschätzung eines Einfamilienhauses
Authors: Spratte Tobias , Jansen David , Maier Laura , Müller Dirk 
Published: December 2024

AbstractIm IBPSA Project 1 wurde neben der Kernbibliothek Modelica‐IBPSA auch die Bibliothek AixLib zur quelloffenen Modellierung von Gebäudeenergiesystemen mit Modelica entwickelt. Verglichen mit dem speziell für die energetische Gebäudesimulation entwickelten quelloffenen Programm EnergyPlus ermöglichen die Modelica‐Bibliotheken eine physikalisch realistischere Modellierung der Regelung moderner Anlagentechnik. In EnergyPlus hingegen ist die Wärmeübertragung durch die Gebäudehülle mit einem höheren Detailgrad modelliert. Fraglich ist, in welchem Ausmaß die in der AixLib getätigten Vereinfachungen die Ergebnisse einer energetischen Gebäudesimulation beeinflussen. In dieser Studie werden die erforderliche Heizleistung und der Heizbedarf eines Einfamilienhauses mittels Jahressimulationen des in der AixLib enthaltenen High‐Order‐Gebäudemodells des Einfamilienhauses und eines EnergyPlus‐Gebäudemodells des Einfamilienhauses ermittelt und verglichen. Die Ergebnisse des AixLib‐Gebäudemodells zeigen einen nach oben verschobenen Verlauf der erforderlichen Heizleistung gegenüber den Ergebnissen des EnergyPlus‐Gebäudemodells. In der kalten Jahreshälfte wird mit dem AixLib‐Gebäudemodell ein etwa 1 %, in der warmen Jahreshälfte ein etwa 31 % und im gesamten Jahr ein etwa 2 % höherer Heizbedarf berechnet. Die in EnergyPlus umgesetzte zusätzliche Diskretisierung der einzelnen Wandschichten führt insbesondere im Sommer zu höheren Oberflächentemperaturen der Außenwände, wodurch ein geringerer Heizbedarf berechnet wird.
Cherry‐Picking Tolerance About Untruthful News
Authors: Li Xilin , Hsee Christopher K. , Wang Shu 
Published: December 2024

ABSTRACTPeople are increasingly worried about untruthfulness in news reporting. We distinguish between two types of untruthfulness: apparent untruthfulness (containing false information) and consequential untruthfulness (giving readers a wrong impression of the truth). Consequential untruthfulness can be caused by both the presence of false information and cherry‐picking (reporting only parts of the truth). Despite this, we find that people's perception of untruthfulness depends largely on apparent untruthfulness. Consequently, they treat news that cherry‐picks information less negatively (e.g., less likely to criticize it and more likely to share it with others) than they treat news that contains false information, when the former is more consequentially untruthful than the latter. We dub this phenomenon as cherry‐picking tolerance. We also find that prompting people to think about the consequence of the news report (i.e., the impressions people form after they read the news reports) will mitigate the cherry‐picking tolerance. This research draws attention to the widespread practice of cherry‐picking in news reporting and calls for a new look at what constitutes fake news.
A PRISMA‐Based Systematic Review on Economic, Social, and Governance Practices: Insights and Research Agenda
Authors: Ed‐Dafali Slimane , Adardour Zahra , Derj Atar , Bami Adil , Hussainey Khaled 
Published: December 2024

ABSTRACTThe article synthesizes existing research on environmental, social, and governance (ESG) practices and explores their impact on corporate sustainability and financial outcomes. [Correction added on 17 December 2024, after first online publication: In the Abstract section, the definition of ESG has been corrected from ‘economic, social, and governance’ to ‘environmental, social, and governance’.] A systematic literature review (SLR) followed PRISMA guidelines, analyzing 85 peer‐reviewed articles from high‐quality journals indexed in Scopus. The results reveal that robust governance mechanisms—such as board diversity, strategic integration of ESG criteria, and effective risk management—are key drivers of enhanced ESG performance and corporate profitability. However, the findings also highlight significant gaps in current knowledge, particularly regarding emerging concepts like green innovation, ESG controversies, and digital transformation. The study concludes that further research is needed to develop a more nuanced understanding of how different governance structures and ESG practices interact and to provide clearer guidance for policymakers and corporate managers in fostering sustainable business practices.
Bridging the Gap Between the Source of Innovation and the Implementation of Circular Economy Principles in SMEs Within Emerging Economies: The Mediating Role of Frugal Innovation
Authors: Perera Ranjika Lalani , Badir Yuosre F. 
Published: December 2024

ABSTRACTSmall and medium‐sized enterprises (SMEs) in emerging economies encounter various challenges when it comes to adopting circular economy (CE) principles due to their resource‐constrained contexts. Consequently, they often rely on innovation to facilitate the implementation of these principles. In this study, we explore the effect of source of innovation, generation or adoption, on the implementation of CE principles within SMEs in emerging economies. We also go one step further and examine the mechanism through which the source of innovation affects the implementation of CE principles. We argue that in resource‐constrained contexts, firm may use frugal innovation as a mediator in the relationship between the source of innovation and the implementation of CE principles. We collected 306 survey responses from SMEs in India and Pakistan and analyzed the data through PLS‐SEM using SMARTPLS4 software. The findings indicate that both innovation generation and innovation adoption have a positive effect on implementing CE principles, with innovation adoption showing the most significant effect. Additionally, we discovered that frugal innovation plays a partial mediator role in the relationship between innovation generation/innovation adoption and implementing CE principles. These results suggest that SMEs in emerging economies can leverage both innovation generation and adoption to advance the adoption of CE principles, fostering the development of frugal innovations in the process, which further drive the implementation of CE principles. Moreover, our findings contribute to the ongoing research debate regarding the relationship between frugal innovation and sustainability, highlighting the impact of frugal innovation on environmental sustainability.
Antiviral Potential and In Silico Insights of Polyphenols as Sustainable Phytopharmaceuticals: A Comprehensive Review
Authors: Mahapatra Ananya Das , Paul Indrani , Dasgupta Sanjukta , Roy Oliva , Sarkar Srinjoy , Ghosh Tusha , Basu Sayantan , Chattopadhyay Debprasad 
Published: December 2024

ABSTRACTPolyphenols, particularly flavonoids, are reported to have health‐promoting, disease‐preventing abilities and several polyphenols having a wide spectrum of antiviral activities can be explored for preventive and/or therapeutic purposes. We have compiled the updated literature of diverse polyphenols active against common viral diseases, including herpes, hepatitis, influenza, rota and SARS‐corona‐viruses. The antiviral activity of bioactive polyphenols depends on the hydroxyl and ester groups of polyphenol molecules, as compounds with five or more hydroxyl groups and three specific methoxy groups showed antiviral potential, like anti‐rabies activity. This comprehensive review will explore selective polyphenols isolated from common ethnomedicinal or food plants. Comparing bioactivities of structurally related polyphenols and using bioinformatics studies, we have explored the three most promising phyto‐antivirals, including chrysin, resveratrol and quercetin, available in many foods and medicinal plants. Quercetin showed a maximum interaction score with human genes. We also explore the intricate structure–activity relationship between these polyphenols and pathogenic viruses with their mechanisms of antiviral action in selected virus models. Here, we report the promising potential of some phyto‐polyphenols in the management of viral diseases through an in‐depth analysis of the structure and bioactivity of these compounds.
Multiscale structural characterization, physicochemical properties, and in vitro digestibility of pea starch produced by two different processes
Authors: Sun Zhiwei , Zhao Xiangying , Liu Liping , He Qiangzhi , Li Ruiguo , Zhang Jiaxiang 
Published: December 2024

AbstractBackground and ObjectivesDry grinding pea starch (DG) and wet grinding pea starch (WG) are two primary industrial starches with significantly different structures, physicochemical properties, and application potentials. To date, there have been no detailed studies examining these differences. Therefore, the aim of this study was to (i) investigate the effects of dry grinding and wet grinding on the structure of pea starch, and (ii) examine how the structure of pea starch influences its physicochemical properties and digestibility.FindingsThe crystallinity (35.75%), medium and long amylopectin (AP) chains (22.00%), swelling power (17.23 g/g), gelatinization temperature (76.4°C), and gelatinization viscosity (5585.0 cP) of WG were higher than those of DG (24.29%, 20.36%, 16.90 g/g, 75.9°C, and 5196.3 cP). In contrast, the average particle size (APS) (24.31 μm), resistant starch content (45.80%), and gel hardness (509.70 g) were lower than those of DG (25.68 μm, 52.13%, and 617.53 g).ConclusionsSignificant structural differences exist between WG and DG, with APS and AP chain length distribution being the primary factors contributing to the distinct physicochemical characteristics of the two pea starches.Significance and NoveltyThis is the first detailed comparison of the properties of commercial pea starch produced by two different processes. The results provide theoretical insights that underpin the use of pea starch in functional foods and promote the development of new starch‐based products.
Normalization Strategies for Lipidome Data in Cell Line Panels
Authors: Leegwater Hanneke , Zhang Zhengzheng , Zhang Xiaobing , Hankemeier Thomas , Harms Amy C. , Zweemer Annelien J. M. , Le Dévédec Sylvia E. , Kindt Alida 
Published: December 2024

ABSTRACTSample collection can significantly affect lipid concentration measurements in cell line panels, concealing intrinsic differences between cancer subtypes. Most quality control steps in lipidomic data analysis focus on controlling technical variation. Correcting for the total amount of biological material remains an additional challenge for cell line panels. Here, we investigated how we can normalize lipidomic data acquired from multiple cell lines to correct for differences in sample biomass. We studied how commonly used data normalization and transformation strategies influence the resulting lipid data distributions. We compared normalization by biological properties including cell count and total protein concentration, to statistical and data‐based approaches, such as median, mean, or probabilistic quotient‐based normalization. We used intraclass correlations to estimate how normalization influenced the similarity between replicates. Normalizing lipidomic data by cell count improved the similarity between replicates but only for cell lines with similar morphologies. When comparing cell line panels with diverse morphologies neither cell count nor protein concentration was sufficient to increase the similarity of lipid abundances between cell line replicates. Data‐based normalizations increased these similarities but resulted in a bias towards the large and variable lipid class of triglycerides. These artifacts are reduced by normalizing for the abundance of only structural lipids. We conclude that there is a delicate balance between improving the similarity between replicates and avoiding artifacts in lipidomic data and emphasize the importance of an appropriate normalization strategy in studying biological phenomena using lipidomics.
B(C6F5)3‐Catalyzed Regiodivergent Thioetherifications of Alkenes via Thiiranium Intermediates: Experimental and Computational Insights
Authors: Alotaibi Nusaybah , Babaahmadi Rasool , Das Sampurna , Richards Emma , Wirth Thomas , Pramanik Milan , Melen Rebecca L. 
Published: December 2024

AbstractPrecise control of selective alkene functionalization is a continuing challenge in the chemical community. In this study, we develop a substitution‐controlled regiodivergent thioetherification of di‐ or trisubstituted alkenes using 10 mol % tris(pentafluorophenyl)borane [B(C6F5)3] as a catalyst and N‐thiosuccinimide as a sulfenylating reagent. This metal‐free borane catalyzed C−S bond forming method is utilized for a Csp2−H sulfenylation reaction to synthesize an array of diphenylvinylsulfide derivatives with good to excellent yields (25 examples, up to 91 % yield). Some of the products exhibit aggregation‐induced emission luminogen properties used in organic light‐emitting diodes (OLEDs), chemical sensors, and biological imaging units. Depending upon the starting alkene, Csp3−S sulfenylation products could also be generated regioselectively. A variety of allylic thioethers from α‐alkyl substituted styrenes were isolable in good yields and selectivities (14 examples, up to 67 % yield). The DFT‐supported mechanistic study confirms that the reaction proceeds via a thiiranium ion intermediate, where the regioselectivity and product formation is determined by the alkene substituents which influence the activation barriers and energy profiles. Diphenylvinylsulfide derivatives can also be efficiently transformed into a range of synthetically valuable compounds, including vinyl sulfoxides, vinyl sulfones, and vinyl sulfoximines.
The Impact of Preprocedural Blood Pressure on Outcome After M‐TEER: The Paradox or Something Else?
Authors: Tadic Marijana , Schneider Leonhard , Nita Nicoleta , Felbel Dominik , Paukovitsch Michael , Gröger Mathias , Keßler Mirjam , Rottbauer Wolfang 
Published: December 2024

ABSTRACTObjectiveThe aim of this study was to investigate the influence of systolic blood pressure (SBP) values on admission on the outcome of mitral transcatheter edge‐to‐edge repair (M‐TEER).MethodologyWe included all patients who underwent interventional MV repair in our institution between January 2010 and October 2020. All data are obtained from the MiTra ULM registry. Based on SBP values measured on admission, all patients were divided into four groups: < 120, 120−129, 130−139, and ≥ 140 mmHg.ResultsEight hundred and fifty‐eight patients were included in this study. There were no major differences in demographic and clinical characteristics between the four observed groups. The patients with SBP on admission ≥ 140 mmHg had the lowest prevalence of functional MR and the highest LVEF. Higher SBP at admission (HR 0.74, 95% CI: 0.63−0.87) and preprocedural LVEF values (HR 0.99, 95% CI: 0.97−0.99) were predictors of lower 1‐year mortality but did not impact 1‐year hospitalization rate or MACE in the whole study population. When patients were separated into two groups according to the mechanisms of MR (functional and structural), the results showed that higher SBP on admission and better preprocedural LVEF were associated with significantly lower 1‐year CV mortality in both groups of patients, with functional and structural MR. Higher SBP at admission was also associated with lower 1‐year CV mortality (HR 0.73, 95% CI: 0.55−0.96) in patients with preserved ejection fraction (LVEF > 50%), but not with 1‐year rehospitalization and MACE.ConclusionHigher SBP on admission (> 140 mmHg) is an independent predictor of a better 1‐year outcome in patients treated with M‐TEER. The effect of higher SBP on outcome after M‐TEER should be further investigated.
FAK and p130Cas Modulate Stiffness‐Mediated Early Transcription and Cellular Metabolism
Authors: Tumenbayar Bat‐Ider , Pham Khanh , Biber John C. , Tutino Vincent M. , Brazzo Joseph A. , Yao Peng , Bae Yongho 
Published: December 2024

ABSTRACTCellular metabolism is influenced by the stiffness of the extracellular matrix. Focal adhesion kinase (FAK) and its binding partner, p130Cas, transmit biomechanical signals, such as substrate stiffness, to the cell to regulate a variety of cellular responses, but their roles in early transcriptional and metabolic responses remain largely unexplored. We cultured mouse embryonic fibroblasts with or without siRNA‐mediated FAK or p130Cas knockdown and assessed the early transcriptional responses of these cells to placement on soft and stiff substrates by RNA sequencing and bioinformatics analyses. Exposure to the stiff substrate altered the expression of genes important for metabolic and biosynthetic processes, and these responses were influenced by knockdown of FAK and p130Cas. Our findings reveal that FAK‐p130Cas signaling mechanotransduces substrate stiffness to early transcriptional changes that alter cellular metabolism and biosynthesis.