bluuebunny/crossref_metadata_2025_split huggingface dataset:
Investigation of ultrahigh‐performance liquid chromatography/travelling‐wave ion mobility/time‐of‐flight mass spectrometry for fast profiling of fatty acids in the high Arctic sea surface microlayer
Authors: Mashayekhy Rad Farshid , Leck Caroline , Ilag Leopold L. , Nilsson Ulrika 
Published: March 2018

RationaleFatty acids are enriched in the ocean surface microlayer (SML) and have as a consequence been detected worldwide in sea spray aerosols. In searching for a relationship between the properties of the atmospheric aerosol and its ability to form cloud condensation nuclei and to promote cloud droplet formation over remote marine areas, the role of surface active fatty acids sourced from the SML is of interest to be investigated. Here we present a fast method for profiling of major fatty acids in SML samples collected in the high Arctic (89°N, 1°W) in the summer of 2001.MethodsUltrahigh‐performance liquid chromatography (UHPLC)/travelling‐wave ion mobility spectrometry (TWIMS)/time‐of‐flight (TOF) mass spectrometry (MS) for profiling was evaluated and compared with UHPLC/TOFMS. Except for evaporation and centrifugation, no sample preparation was necessary prior to the analysis.ResultsTOFMS data on accurate mass, isotopic ratios and fragmentation patterns enabled identification of the fatty acids. The TWIMS dimension added to the selectivity by extensive reduction of the noise level and the entire UHPLC/TWIMS/TOFMS method provided a fast profiling of the acids, ranging from C8 to C24. Hexadecanoic and octadecanoic acids were shown to yield the highest signals among the FAs detected in a high Arctic SML sample, followed by the unsaturated octadecenoic and octadecadienoic acids. The predominance of signal from even‐numbered carbon chains indicates a mainly biogenic origin of the detected FAs.ConclusionsThis study presents a fast alternative method for screening and profiling of FAs, which has the advantage of not requiring any complicated sample preparation, thus limiting the loss of analytes. Almost no manual handling, together with the very small sample volumes needed, is certainly beneficial for the determination of trace amounts and should open up the field of applications to also include atmospheric aerosol and fog.
Principal component analysis of normalized full spectrum mass spectrometry data in multiMS‐toolbox: An effective tool to identify important factors for classification of different metabolic patterns and bacterial strains
Authors: Cejnar Pavel , Kuckova Stepanka , Prochazka Ales , Karamonova Ludmila , Svobodova Barbora 
Published: March 2018

RationaleExplorative statistical analysis of mass spectrometry data is still a time‐consuming step. We analyzed critical factors for application of principal component analysis (PCA) in mass spectrometry and focused on two whole spectrum based normalization techniques and their application in the analysis of registered peak data and, in comparison, in full spectrum data analysis. We used this technique to identify different metabolic patterns in the bacterial culture of Cronobacter sakazakii, an important foodborne pathogen.MethodsTwo software utilities, the ms‐alone, a python‐based utility for mass spectrometry data preprocessing and peak extraction, and the multiMS‐toolbox, an R software tool for advanced peak registration and detailed explorative statistical analysis, were implemented. The bacterial culture of Cronobacter sakazakii was cultivated on Enterobacter sakazakii Isolation Agar, Blood Agar Base and Tryptone Soya Agar for 24 h and 48 h and applied by the smear method on an Autoflex speed MALDI‐TOF mass spectrometer.ResultsFor three tested cultivation media only two different metabolic patterns of Cronobacter sakazakii were identified using PCA applied on data normalized by two different normalization techniques. Results from matched peak data and subsequent detailed full spectrum analysis identified only two different metabolic patterns – a cultivation on Enterobacter sakazakii Isolation Agar showed significant differences to the cultivation on the other two tested media. The metabolic patterns for all tested cultivation media also proved the dependence on cultivation time.ConclusionsBoth whole spectrum based normalization techniques together with the full spectrum PCA allow identification of important discriminative factors in experiments with several variable condition factors avoiding any problems with improper identification of peaks or emphasis on bellow threshold peak data. The amounts of processed data remain still manageable. Both implemented software utilities are available free of charge from http://uprt.vscht.cz/ms.
Analytical approach for characterization of morphology and chemistry of a CH3NH3PbI3/TiO2 solar cell layered system
Authors: Rades Steffi , Oswald Frederic , Narbey Stephanie , Radnik Jörg , Hodoroaba Vasile‐Dan 
Published: March 2018

Manufacturing of new perovskite layered solar cells with constant high light conversion efficiency over time may be hampered by the loss of efficiency caused by structural and/or chemical alterations of the complex layered system. SEM/EDX combined with XPS were chosen as an appropriate methodical approach to characterize perovskite laboratory cells in depth and at surface, before and after light exposure. The layered perovskite system investigated here is based on glass covered with fluorine doped tin oxide, followed by thin films of TiO2, ZrO2, and a thick monolithic carbon. TiO2 film is subdivided into a dense layer covered by porous one constituted of nanoparticles of truncated bipyramidal shape. This layered system serves as the matrix for the perovskite. EDX spectral maps on cross sections of specimen have shown that Pb and I are distributed homogeneously throughout the porous layers C, ZrO2, and TiO2. SEM/EDX data show that 20 weeks of ambient daylight did not change significantly the in‐depth distribution of the elemental composition of Pb and I throughout the entire solar cell system. It was confirmed with EDX that nanoparticles identified in high‐resolution SEM micrographs contain mainly Pb and I, indicating these to be the perovskite crystals. However, a compositional and chemical altering began in the near‐surface region of the outermost ~10 nm after 2 months of illumination which was observed with XPS.
Environmental water efficiency: Maximizing benefits and minimizing costs of environmental water use and management
Authors: Horne Avril C. , O'Donnell Erin L , Loch Adam J. , Adamson David C. , Hart Barry , Freebairn John 
Published: March 2018

Environmental water management is a relatively new discipline, with concepts, management practice and institutional mechanisms that are still emerging. The efficient and effective use of environmental water to maximize environmental benefits, or environmental water use efficiency, is one such emerging concept. Currently, much of the focus is on allocative efficiency, where the objective is to achieve a better balance between consumptive and environmental water uses in a cost‐effective way. However, this may not provide the most efficient and effective way to manage environmental water in the long term, where managers are seeking productive (or operational) efficiency. Here, the objective is to maximize environmental outcomes relative to the cost of managing the available resource. This paper explores the concept of water use efficiency in the context of environmental water.This article is categorized under:

Engineering Water > Planning Water
Human Water > Value of Water
A Commentary on Commercial Genetic Testing and the Future of the Genetic Counseling Profession
Authors: Wolff Nicholas D. , Wolff Jon A. 
Published: March 2018

AbstractCommercial genetic testing laboratories are increasingly employing genetic counselors. As a result, the role of these or many genetic counselors is shifting from primarily direct patient counseling in clinics and hospitals to more laboratory‐centered activities that involve case coordination, customer liaison, variant classification, marketing, and sales. Given the importance of these commercial entities to the genetic counseling profession, this commentary examines the current financial situation of four publicly traded, genetic testing companies. It also explores how the various roles of genetic counselors are likely to be affected by the financial pressures these companies face.
Maternity Leave and Mothers’ Long-Term Sickness Absence: Evidence From West Germany
Authors: Guertzgen Nicole , Hank Karsten 
Published: March 2018

Abstract
Exploiting unique German administrative data, we estimate the association between an expansion in maternity leave duration from two to six months in 1979 and mothers’ postbirth long-term sickness absence over a period of three decades after childbirth. Adopting a difference-in-difference approach, we first assess the reform’s labor market effects and, subsequently, prebirth and postbirth maternal long-term sickness absence, accounting for the potential role of the reform in mothers’ selection into employment. Consistent with previous research, our estimates show that the leave extension caused mothers to significantly delay their return to work within the first year after childbirth. We then provide difference-in-difference estimates for the number and length of spells of long-term sickness absence among returned mothers. Our findings suggest that among those returned, mothers subject to the leave extension exhibit a higher incidence of long-term sickness absence compared with mothers who gave birth before the reform. This also holds true after we control for observable differences in prebirth illness histories. At the same time, we find no pronounced effects on mothers’ medium-run labor market attachment following the short-run delay in return to work, which might rationalize a negative causal health effect. Breaking down the results by mothers’ prebirth health status suggests that the higher incidence of long-term sickness absence among mothers subject to the reform may be explained by the fact that the reform facilitated the reentry of a negative health selection into the labor market.
Very low‐protein diet to postpone renal failure: Pathophysiology and clinical applications in chronic kidney disease
Authors: Bellizzi Vincenzo , Calella Patrizia , Carrero Juan Jesus , Fouque Denis 
Published: March 2018

AbstractThe uremic syndrome is a metabolic disorder characterized by the impairment of renal handling of several solutes, the resulting accumulation of toxic products and the activation of some adaptive but detrimental mechanisms which all together contribute to the progression of renal damage. In moderate to advanced renal failure, the dietary manipulation of nutrients improves metabolic abnormalities and may contribute to delay the time of dialysis initiation. This commentary focuses on the physiopathological rationale and the clinical application of the very low‐protein diet supplemented with ketoanalogs for the management of chronic kidney disease.
Precarity in Angolan diamond mining towns, 1920–2014: tracing agency of the state, mining companies and urban households
Authors: Udelsmann Rodrigues Cristina , Bryceson Deborah Fahy 
Published: March 2018

AbstractAfter nearly 30 years of civil war, Angola gained peace in 2002. The country's diamond and oil wealth affords the national government the means to pursue economic reconstruction and urban development. However, in the diamond-producing region of Lunda Sul, where intense fighting between MPLA and UNITA forces was waged, the legacy of war lingers on in the form of livelihood uncertainty and uneven access to the benefits of the state's urban development programmes. There are three main interactive agents of urban change: the Angolan state, the mining corporations, and not least urban residents. The period has been one of shifting alignments of responsibility for urban housing, livelihoods and welfare provisioning. Beyond the pressures of post-war adjustment, the wider context of global capital investment and labour market restructuring has introduced a new surge of corporate mining investment and differentiated patterns of prosperity and precarity in Lunda Sul.
Folding of copper proteins: role of the metal?
Authors: Ariöz Candan , Wittung-Stafshede Pernilla 
Published: March 2018

AbstractCopper is a redox–active transition metal ion required for the function of many essential human proteins. For biosynthesis of proteins coordinating copper, the metal may bind before, during or after folding of the polypeptide. If the metal binds to unfolded or partially folded structures of the protein, such coordination may modulate the folding reaction. The molecular understanding of how copper is incorporated into proteins requires descriptions of chemical, thermodynamic, kinetic and structural parameters involved in the formation of protein–metal complexes. Because free copper ions are toxic, living systems have elaborate copper-transport systems that include particular proteins that facilitate efficient and specific delivery of copper ions to target proteins. Therefore, these pathways become an integral part of copper protein folding in vivo. This review summarizes biophysical-molecular in vitro work assessing the role of copper in folding and stability of copper-binding proteins as well as protein–protein copper exchange reactions between human copper transport proteins. We also describe some recent findings about the participation of copper ions and copper proteins in protein misfolding and aggregation reactions in vitro.
Validity of caregiver-report measures of language skill for Wolof-learning infants and toddlers living in rural African villages
Authors: WEBER Ann M. , MARCHMAN Virginia A. , DIOP Yatma , FERNALD Anne 
Published: March 2018

AbstractValid indigenous language assessments are needed to further our understanding of how children learn language around the world. We assessed the psychometric properties and performance of two caregiver-report measures of Wolof language skill (language milestones achieved and vocabulary knowledge) for 500 children (ages 0;4 to 2;6) living in rural Senegal. Item response models (IRM) evaluated instrument- and item-level performance and differential function by gender. Both caregiver-report measures had good psychometric properties and displayed expected age and socioeconomic effects. Modest concurrent validity was found by comparing the caregiver-report scores to transcribed child language samples from a naturalistic play session. The caregiver-report method offers a valid alternative to more costly tools, such as direct behavioral assessments or language sampling, for measuring early language development in non-literate, rural African communities. Recommendations are made to further improve the performance of caregiver-report measures of child language skill in these settings.
Toward Delegation: Social Policy Centralization in Toronto, 1870–1929
Authors: Lucas Jack 
Published: March 2018

Abstract:Scholars of social policy development in the United States and elsewhere have recently focused on the historical and contemporary importance of complex, delegated welfare state governance. In this article, I outline the emergence of a coordinated urban welfare state in the city of Toronto between 1870 and 1929, describing the creation of both public and private forms of coordination and centralization. I argue that we must understand social policy development in this period as resulting from the interaction of three policy coalitions: municipal traditionalists, municipal progressives, and social work professionals, and that social policy centralization occurred as a result of an alliance between municipal progressives and social work professionals. To explain the long-term development of social policy in Canada and elsewhere, I argue, we must understand the interaction among these internal coalitions in the social policy field and the ways that broader fiscal and cultural changes strengthened or weakened each coalition over time.
“Outside the Pyramid”: Clerical Work, Corporate Affirmative Action, and Working Women’s Barriers to Upward Mobility
Authors: Elias Allison L. 
Published: March 2018

Abstract:Although women have made tremendous gains at work, a striking degree of sex segregation still exists. For a generation of women who were working in low-paying, administrative support positions during the promising era of Title VII, affirmative action did not offer upward mobility. In the 1970s, as employers and regulators began implementing affirmative action amid the gendered structure of internal labor markets, women who were already in clerical roles remained outside the managerial pipeline. Women in 9to5, the National Association of Working Women, sought to bridge the gap between female-dominated clerical and male-dominated managerial ladders using collective action. Yet business and government did not enforce affirmative action such that the clustering of women in low-paid clerical positions constituted discrimination on the basis of sex. Work experience on the clerical ladder remains inadequate training for positions on the managerial ladder.
A Forgotten Chapter in the History of International Commercial Arbitration: The Slave Trade's Dispute Settlement System
Authors: MARTINEAU ANNE-CHARLOTTE 
Published: March 2018

AbstractThis article is part of the ongoing efforts to write a critical history of international arbitration in commercial and investment matters. It examines the ways in which the Spanish crown and its concessionaries set up a mechanism to settle legal disputes pertaining to the transatlantic slave trade. The transformation ofasientos de negrosfrom limited royal contracts to large-scale monopolies awarded to foreign chartered companies during the sixteenth, seventeenth and early eighteenth centuries was accompanied by the creation of an international commercial arbitration system. Why was this system set up, how did it work, and what was its faith? The overall aim of the article is to invite international lawyers to rethink the history of international arbitration and pay closer attention to the ‘private’ dimensions of formal and informal imperialism. It also attempts to bridge the historical investigation and contemporary commentary. In the conclusion, I argue that this study allows us, in a mirroring effect, to question the idea that today's dispute settlement mechanism was conceived as a means to ‘depoliticize’ international investment law. What the introduction of arbitration achieves is to place some fundamental questions out of sight. Today, as in the past, arbitrators work from within the system; their work rests on a series of unspoken – and yet highly political – premises about the organization of economic life and the distribution of values.
The Association between Cardiopulmonary Resuscitation in Out-of-Hospital Settings and Chest Injuries: A Retrospective Observational Study
Authors: Takayama Wataru , Koguchi Hazuki , Endo Akira , Otomo Yasuhiro 
Published: March 2018

AbstractObjectivesThe aim of this study was to assess the risk of cardiopulmonary resuscitation (CPR) performed in out-of-hospital settings for chest injuries in patients with out-of-hospital cardiac arrest (OHCA).MethodsThis retrospective, observational study was conducted in an emergency critical care medical center in Japan. Non-traumatic OHCA patients transferred to the hospital from April 2013 through August 2016 were analyzed. The outcome was defined by chest injuries related to CPR, which is composite of rib fractures, sternal fractures, and pneumothoraces. A multivariate logistic regression analysis was performed to assess the independent risk factors for chest injuries related to CPR. The threshold of out-of-hospital CPR duration that increased risk of chest injuries was also assessed.ResultsA total of 472 patients were identified, of whom 233 patients sustained chest injuries. The multivariate logistic regression model showed that the independent risk factors for chest injuries were age and out-of-hospital CPR duration (age: AOR=1.06 [95% CI, 1.04 to 1.07]; out-of-hospital CPR duration: AOR=1.03 [95% CI, 1.01 to 1.05]). In-hospital CPR duration was not an independent risk factor for chest injuries. When the duration of out-of-hospital CPR extended over 15 minutes, the likelihood of chest injuries increased; however, this association was not statistically significant.ConclusionsLong duration of out-of-hospital CPR was an independent risk factor for chest injuries, possibly due to the difficulty of maintaining adequate quality of CPR. Further investigations to assess the efficacy of alternative CPR devices are expected in cases requiring long transportation times.TakayamaW, KoguchiH, EndoA, OtomoY. The association between cardiopulmonary resuscitation in out-of-hospital settings and chest injuries: a retrospective observational study. Prehosp Disaster Med. 2018;33(2):171–175.
How accurate is the prevalence of overweight and obesity in children and adolescents derived from self-reported data? A meta-analysis
Authors: He Jinbo , Cai Zhihui , Fan Xitao 
Published: March 2018

AbstractObjectiveThe aim of the current meta-analysis was to evaluate the accuracy of using BMI based on self-reported height and weight (BMIsr) to estimate the prevalence of overweight and obesity among children and adolescents.DesignA systematic literature search was conducted to select studies that compared the prevalence rates of overweight and obesity based on BMIsrand BMIm(BMI based on measured height and weight). A random-effect model was assumed to estimate summary prevalence rates and prevalence ratio (PR).ResultsThirty-seven studies were included. The aggregated prevalence of overweight and obesity based on BMIsr(0·190, 95 % CI 0·163, 0·221) was significantly lower than that based on BMIm(0·233, 95 % CI 0·203, 0·265). The pooled mean PR was 0·823 (95 % CI 0·775, 0·875). Moderator analyses showed that the underestimation was related to gender, age, weight status screened (overweightv. obesity) and weight status screening tool.ConclusionsBMIsrmay produce less biased results under some conditions than others. Future researchers using BMIsrmay consider these findings and avoid the conditions that could lead to more severe underestimation of the prevalence of overweight and obesity among children and adolescents.
Can't wait to get my pension: the effect of raising the female early retirement age on income, poverty and deprivation
Authors: CRIBB JONATHAN , EMMERSON CARL 
Published: March 2018

AbstractWe estimate the impact of increasing the female early retirement age (ERA) on household living standards. Examining the increase in the female ERA from 60 to 63 in the UK, we find increased earnings only partially offset lost public pension income, leaving affected women's household incomes £32 per week lower on average. The proportional effect was substantially larger for women in lower income households. This increased the income poverty rate among affected women by 6.4 percentage points. We find no evidence of an increased inability to afford important material items, potentially suggesting that material deprivation has been avoided through smoothing of consumption.