bluuebunny/crossref_metadata_2025_split huggingface dataset:
Therapeutic Potential of Phytomedicines and Novel Polymeric Strategies for Significant Management of Candidiasis
Authors: Rohilla Surbhi , Bhatt D.C. , Gupta Aditi 
Published: May 2018

Background:
Candidiasis is one of the most common opportunistic fungal infections caused by genus
Candida. The genus is composed of around 200 species. The most virulent among all are, Candida albicans followed
by various nonalbicans species. Despite various treatments available, the incidence of severe systemic
fungal infections is increasing, and with it the related morbidity and mortality, in relation to the misuse of antimicrobials
and the emergence of drug-resistant fungal species. Therefore, various novel therapeutic approaches need
to be developed and explored to overcome these limitations and effective management of candidiasis.

Objective:
In this review, we focused on natural herbal remedies and significance of novel formulation approaches
for the treatment of candidiasis.

Conclusion:
The reported studies suggested the promising role of phytomedicines and novel polymeric drug
delivery systems in therapeutic management of candidiasis. Phytomedicines are effective substitutes of synthetic
drugs as they are inexpensive with lesser number of side effects. Various novel particulate approaches can be
successfully used to reduce fungal burden at the target site.
A Convenient Method for the Synthesis of Chromeno[4,3-b]pyridines Via Three-component Reaction
Authors: Nikookar Hamideh , Moghimi Setareh , Sayahi Mohammad Hosein , Mahdavi Mohammad , Ranjbar Parviz Rashidi , Firoozpour Loghman , Foroumadi Alireza 
Published: May 2018

Aim and Objective:
The importance of Chromeno[4,3-b]pyridines in bioactive
compounds, highlighted the ongoing research on developing novel methods for the construction of
this heterocyclic scaffold. Regarding the advantageous features of multi-component reactions in
organic synthesis, we will try to synthesize pyridocoumarins through this method.

Materials and Methods:
Chromeno[4,3-b]pyridines were conveniently prepared from a threecomponent
condensation reaction between 4-hydroxy coumarin, ammonia and ethyl 2,4-dioxo-4-
arylbutanoates in refluxing n-propanol. The synthesized compounds were characterized by NMR, IR
and Mass spectroscopy.

Results:
The reaction proceeded through an in situ formed 4-amino coumarin, affording eight new
target compounds in good yields.

Conclusion:
This method introduce a novel approach to ethyl 4-aryl-5-oxo-5H-chromeno[4,3-
b]pyridine-2-carboxylate derivatives and allow organic chemists to prepare 4-aminocoumarin in
reaction medium.
Os sons dos alarmes clínicos estão chamando a sua atenção? / Are the sounds of clinical alarms catching your attention?
Authors: Miranda Renata Pinto Ribeiro , Ribeiro Luiz Sérgio Pinto , Custódio Renata Aparecida Ribeiro , Mello Carlos Henrique Pereira 
Published: May 2018

Nos últimos anos, tem sido notável a rápida evolução dos equipamentos médicos e da consequente aquisição desses dispositivos tecnologicamente mais sofisticado por hospitais e unidades de saúde.1 Podem-se ter equipamentos médicos para uma infinidade de objetivos junto ao paciente, seja para tratamento, diagnóstico ou monitorização dos indivíduos. Ademais, tais equipamentos podem apresentar alarmes ou não.2Alarmes são considerados3 como dispositivos visuais e/ou auditivos, presentes em diversos equipamentos médicos hospitalares, com o intuito de manterem a segurança dos pacientes. Isso porque quando alarmes trabalham como previsto são de extrema importância por sinalizarem mudanças nos equipamentos. Porém, o que se tem observado na prática clínica e verificado na literatura são centenas de alarmes soando constantemente dentro das diversas instituições hospitalares, aparentando estarem fora de controle.4Sabe-se que os níveis de ruídos em hospitais encontram-se superiores aos recomendados por diversas instituições regulamentadores,5 como para a United States Environmental Protection Agency, que recomenda que os níveis de ruído em ambiente hospitalar não devam exceder 45 dB durante o dia e 35 dB durante a noite. A Organização Mundial de Saúde recomenda de 30-40 dB para ambientes hospitalares internos. Segundo a Norma Brasileira NBR 10151, os valores das medidas em diversos ambientes hospitalares devem ser a) de 35-45 dB para apartamentos, enfermarias, berçários e centros cirúrgicos; b) de 40-50 dB para laboratórios e áreas para uso do público; e c) de 45-55 dB para os ambientes de serviços.
Asistir a la cita de la posdictadura. Historicidad, performance y políticas del cuerpo entre Emilio García Wehbi y el Periférico de Objetos
Authors: Gelman Constantin Francisco 
Published: May 2018

En diálogo con la reivindicación teórica contemporánea del anacronismo como antídoto contra el historicismo positivista, el artículo explora la obra performática y teatral de Emilio García Wehbi en sus relaciones con la producción del Periférico de Objetos, con la expectativa de investigar qué implica la incorporación del cuerpo escénico en una concepción compleja y fracturada de la temporalidad del arte. En la instauración de la posdictadura como un efecto retroactivo de producción de historicidad a lo largo del tiempo escindido de la obra, la desincronización aparece como un acto político de desafío a las biopolíticas de Estado. La suscitación de una teoría sobre las relaciones entre lenguaje y cuerpo adecuada a este decir escénico permite además recorrer algunas disputas conceptuales actuales y defender una concepción del montaje como modo de comprender la articulación de tiempos, cuerpos y sujetos en su heterogeneidad.
National Rates of Initiation and Intensification of Antidiabetic Therapy Among Patients With Commercial Insurance
Authors: Gilstrap Lauren G. , Mehrotra Ateev , Bai Barbara , Rose Sherri , Blair Rachel A. , Chernew Michael E. 
Published: May 2018

OBJECTIVE
Prompt initiation and intensification of antidiabetic therapy can delay or prevent complications from diabetes. We sought to understand the rates of and factors associated with the initiation and intensification of antidiabetic therapy among commercially insured patients in the U.S.

RESEARCH DESIGN AND METHODS
Using 2008–2015 commercial claims linked with laboratory and pharmacy data, we created an initiation cohort with no prior antidiabetic drug use and an HbA1c ≥8% (64 mmol/mol) and an intensification cohort of patients with an HbA1c ≥8% (64 mmol/mol) who were on a stable dose of one noninsulin diabetes drug. Using multivariable logistic regression, we determined the rates of and factors associated with initiation and intensification. In addition, we determined the percent of variation in treatment patterns explained by measurable patient factors.

RESULTS
In the initiation cohort (n = 9,799), 63% of patients received an antidiabetic drug within 6 months of the elevated HbA1c test. In the intensification cohort (n = 10,941), 82% had their existing antidiabetic therapy intensified within 6 months of the elevated HbA1c test. Higher HbA1c levels, lower generic drug copayments, and more frequent office visits were associated with higher rates of both initiation and intensification. Better patient adherence prior to the elevated HbA1c level, existing therapy with a second-generation antidiabetic drug, and lower doses of existing therapy were also associated with intensification. Patient factors explained 7.96% of the variation in initiation and 7.35% of the variation in intensification.

CONCLUSIONS
Approximately two-thirds of patients were newly initiated on antidiabetic therapy, and four-fifths of those already receiving antidiabetic therapy had it intensified within 6 months of an elevated HbA1c in a commercially insured population. Patient factors explain 7–8% of the variation in diabetes treatment patterns.
The relation between self-regulated learning, academic performance of graduate student
Authors: Madihie Amalia , Mos Zarifah 
Published: May 2018

The purpose of this study is to discover possible relationships between self-regulated learning with graduate students’ academic performance. Eighty graduate students from the Learning Sciences Programme and Human Resources Programme at Faculty of Cognitive Sciences and Human Development were randomly selected. Motivated Strategies for Learning Questionnaire (Pintrich, 1991) was piloted and administered. First, the questionnaire was undergone the back-to-back translation (into Malay language version). Two variables that involved in this study were motivation and learning strategies. Academic performance measured to be dependent variable which is the graduate students’ current CGPA. Findings show that there is no relation between motivation and learning strategies with academic performance. Future recommendations are also discussed in this study.
Identifikasi Jenis Gangguan pada Jaringan Transmisi Menggunakan Metode Jaring Syaraf Tiruan
Authors: Widiarsana I Made , Mataram I Made , Sudarmojo Yanu Prapto 
Published: May 2018

Pada jaringan transmisi sering terjadi berbagai macam jenis gangguan, antara lain gangguan hubung singkat satu phasa ke tanah, gangguan hubung singkat phasa ke phasa, gangguan antar phasa ke tanah dan gangguan simetris. Pendeteksian terhadap gangguan tersebut dapat dilakukan dengan metode jaring syaraf tiruan. Jaring syaraf tiruan terdiri dari sejumlah elemen penghitung tak linier yang masing-masing dihubungkan secara paralel melalui suatu pembobot. Proses training pada jaring syaraf tiruan ini terdiri dari proses pelatihan terhadap gangguan hubung singkat satu phasa ke tanah, gangguan hubung singkat phasa dengan phasa, gangguan hubung singkat antar phasa dengan tanah, dan gangguan simetris. Proses pelatihan pada jaringan transmisi ini menggunakan konfigurasi 6 data intput, 10 hidden layer, 6 data target, dan 6 output (6-10-6-6). Hasil pelatihan menunjukkan bahwa nilai arus dan tegangan gangguan untuk semua jenis gangguan pada jaringan transmisi berhasil di bangkitkan, dimana output berupa nilai tegangan dan arus dari proses pelatihan akan disimpan dan dijadikan sebagai refrensi untuk menentukan jenis gangguan hubung singkat yang terjadi pada jaringan transmisi. Data hasil simulasi jaringan transmisi dapat dikatakan normal saat mendekati nilai output atau sebaliknya ketika jaringan transmisi mengalami gangguan hubung singkat.

[TURNITIN CHECK 75 19042017]
GAYA BELAJAR DAN MISKONSEPSI SISWA PADA KONSEP REDOKS DI SMA NEGERI I SUMENEP
Authors: Fajarianingtyas Dyah Ayu , Herowati Herowati , Yuniastri Ratih 
Published: May 2018

Tujuan penelitian ini yaitu untuk memetakan dan menganalisis gaya belajar yang dimiliki siswa miskonsepsi dan menentukan adanya keterkaitan antara gaya belajar dengan miskonsepsi siswa pada konsep kimia. Penelitian ini menggunakan metode penelitian pre-eksperimental dan bentuk desainnya adalah One Shot Case Study. Sampel penelitian ini adalah siswa kelas XI MIA 4 dan XI MIA 6 sejumlah 67 siswa. Pengumpulan data dilakukan melalui tes dan observasi. Teknik analisis data dilakukan dengan reduksi data, paparan data, dan penarikan simpulan. Hasil penelitian menunjukkan bahwa: (1) Peta gaya belajar siswa menunjukkan bahwa siswa yang mengalami miskonsepsi mempunyai gaya belajar yang beragam dan didominasi oleh gaya belajar sensing-intuitive seimbang, visual-verbal seimbang, active-reflektive seimbang dan sequential-global seimbang; (2) Berdasar hasil uji Chi- Square diperoleh bahwa ada hubungan antara gaya belajar siswa dengan miskonsepsi siswa pada dimensi persepsi dan dimensi input gaya belajar siswa.
Penerapan Extreme Programming dalam Membangun Aplikasi Pengaduan Layanan Pelanggan (PaLaPa) pada Perguruan Tinggi
Authors: Azdy Rezania Agramanisti , Rini Arsia 
Published: May 2018

Layanan pengaduan yang dimiliki oleh Perguruan Tinggi umumnya hanya menjadikan mahasiswa sebagai fokus utama dalam peningkatan layanan, hal ini dikarenakan mahasiswa adalah pengguna langsung jasa yang ditawarkan oleh Perguruan Tinggi. Layanan pengaduan tidak memfasilitasi pengaduan yang mungkin dapat diberikan oleh pengguna jasa lainnya, seperti pengguna lulusan atau masyarakat sasaran kegiatan pengabdian masyarakat yang dilakukan oleh dosen Perguruan Tinggi tersebut. Penelitian ini bertujuan membangun sebuah aplikasi berbasis web yang dapat digunakan seluruh pengguna jasa Perguruan Tinggi untuk melakukan pengaduan. Pembangunan aplikasi menerapkan metodologi rekayasa perangkat lunak agar dapat menghasilkan perangkat lunak tepat waktu. Metodologi yang digunakan adalah Extreme Programming. Hasil dari penelitian menunjukkan bahwa penerapan Extreme Programming pada pengembangan aplikasi mengakibatkan pengembangan dapat dilakukan secara cepat dengan jumlah anggota tim yang minimal. Pengembangan dapat dilakukan dengan cepat karena pengembangan aplikasi dimulai dengan membangun komponen yang paling sederhana terlebih dahulu, yaitu komponen verifikasi akun, yang dilanjutkan dengan komponen lainnya. Hasil pengujian menggunakan metode black box aplikasi dapat dijalankan sebagaimana mestinya dan memenuhi acceptance criteria pada user story. AbstractThe complaint service system owned by College generally only focuses on the students in the improvement of services, this is because students are the direct users of the services offered by the College. Complaints service did not facilitate the complaints which may be given by other service users, such as graduates' user or community targeted in the society devotion activities undertaken by the College lecturer. This research aims to build a web-based application that can be used throughout the service users of the College to conduct complaints. Application development applying software engineering methodologies in order to provide the software on time. The methodology used is Extreme Programming. The result of the research shows that the application of the Extreme Programming in the development of applications resulted in development can be done quickly with a minimal number of the team member. The development can be done quickly because the application development started by building the simplest component in advance, i.e. account verification component, followed by other components. The results of the testing using black box method was the application can be run properly and meets the acceptance criteria on a user story.
Hand-Grip Strength: Normative Reference Values and Equations for Individuals 18 to 85 Years of Age Residing in the United States
Authors: Wang Ying-Chih , Bohannon Richard W. , Li Xiaoyan , Sindhu Bhagwant , Kapellusch Jay 
Published: May 2018

Background Hand-grip strength is an indicator of overall strength and a predictor of important outcomes. Up-to-date, population-specific reference values for measurements of grip strength are needed to properly interpret strength outcomes. Objectives To provide population-based grip-strength reference values and equations for US residents 18 to 85 years of age. Methods Hand-grip data from 1232 participants 18 to 85 years of age were extracted from the database of the 2011 normative phase of the US National Institutes of Health Toolbox project in this cross-sectional study. Descriptive reference values and equations were derived from the data. Results The authors present grip-strength reference values using summary statistics (mean, standard deviation, and percentile). The mean grip strength ranged from 49.7 kg for the dominant hand of men 25 to 29 years of age to 18.7 kg for the nondominant hand of women 75 to 79 years of age. The researchers also present reference regression equations for the dominant and nondominant sides of men and women. The explanatory variables in the equations are age, height, and weight. Conclusion The normative reference values and equations provided in this study may serve as a guide for interpreting grip-strength measurements obtained from tested individuals. J Orthop Sports Phys Ther 2018;48(9):685–693. Epub 23 May 2018. doi:10.2519/jospt.2018.7851
Psychometric Properties of the Photograph Series of Daily Activities-Short Electronic Version (PHODA-SeV) in Patients With Chronic Low Back Pain
Authors: Oliveira Crystian Bitencourt , Franco Marcia Rodrigues , Demarchi Samantha Janaina , Smeets Rob Johannes E.M. , Huijnen Ivan P.J. , Morelhão Priscila Kalil , Hisamatsu Thalysi Mayumi , Pinto Rafael Zambelli 
Published: May 2018

Background The Photograph Series of Daily Activities-short electronic version (PHODA-SeV) assesses perceived harmfulness of daily activities in patients with low back pain (LBP). Although there is some evidence that the PHODA-SeV is a reliable and valid tool, its psychometric properties have not been fully investigated. Objectives To investigate the test-retest reliability, measurement error, interpretability, construct validity, and internal and external responsiveness of the PHODA-SeV in patients with chronic LBP. Methods Ninety-one patients were included in the analysis for this prospective cohort study. For reliability purposes, the PHODA-SeV was administered twice, with a 1-week interval before beginning treatment. Pain, disability, and measures of pain-related fear (ie, PHODA-SeV, Fear-Avoidance Beliefs Questionnaire [FABQ], and Tampa Scale of Kinesiophobia [TSK]) were collected before and after the 8-week treatment period. Results The PHODA-SeV showed excellent reliability (intraclass correlation coefficient model 2,1 = 0.91), without evidence of ceiling and floor effects. The construct validity analysis demonstrated fair correlations (r = 0.25–0.50) of the PHODA-SeV with the FABQ, but no correlation with the TSK (r<0.25). For internal responsiveness, the PHODA-SeV showed an effect size of 0.87 and a standardized response mean of 0.92, interpreted as a large effect (greater than 0.80). For external responsiveness, the correlations between the PHODA-SeV and changes in the TSK and FABQ were considered low, and the receiver operating characteristic curve analyses revealed an area under the curve lower than the proposed threshold of 0.70. Conclusion The PHODA-SeV is a reliable tool that can detect changes over time in pain-related fear in patients with chronic LBP undergoing physical therapy treatment. This tool, however, failed to identify those patients who did or did not improve, according to other pain-related fear measures. J Orthop Sports Phys Ther 2018;48(9):719–727. Epub 23 May 2018. doi:10.2519/jospt.2018.7864
ĐẶC ĐIỂM PHÁT SINH CHẤT THẢI RẮN SINH HOẠT VÀ ƯỚC TÍNH PHÁT THẢI KHÍ NHÀ KÍNH TỪ BÃI CHÔN LẤP CHẤT THẢI RẮN THÀNH PHỐ ĐÔNG HÀ, TỈNH QUẢNG TRỊ
Authors: Lan Trần Phong , Liệu Phạm Khắc 
Published: May 2018

Bài báo trình bày kết quả khảo sát lượng chất thải rắn (CTR) sinh hoạt phát sinh, thành phần CTR được chôn lấp ở Bãi chôn lấp thành phố Đông Hà và ước tính lượng khí nhà kính phát thải từ bãi chôn lấp. Từ mẫu CTR lấy ở 50 hộ thuộc 9 phường trong 2 đợt, hệ số phát sinh CTR sinh hoạt ở Đông Hà được xác định là 0,66 kg/người/ngày. Hệ số phát sinh CTR khác nhau có ý nghĩa thống kê giữa các phường, nhưng không khác nhau giữa các hộ có quy mô khác nhau. Kết quả 3 đợt phân tích mẫu CTR tại bãi chôn lấp cho thấy tỷ lệ thành phần hữu cơ dễ phân hủy khá thấp (45,7%) trong khi một số thành phần không có giá trị tái chế như vải sợi, da và cao su khá cao; có thể do các thành phần hữu cơ và có giá trị đã được giữ lại để tái sử dụng và tái chế. Phát thải khí nhà kính từ bãi chôn lấp Đông Hà, ước tính theo mô hình IPCC (2006), tăng dần từ năm 2012 (84 tấn CH4 hay 2109 tấn CO2e) đến 2017 (433 tấn CH4 hay 10.833 tấn CO2e) theo sự gia tăng lượng CTR chôn lấp ở bãi. Các kết quả thu được là hữu ích cho công tác quy hoạch, quản lý CTR của thành phố Đông Hà, đặc biệt theo hướng giảm thiểu biến đổi khí hậu.
Process and outcome indicators for infection control and prevention in European acute care hospitals in 2011 to 2012 – Results of the PROHIBIT study
Authors: Hansen Sonja , Schwab Frank , Zingg Walter , Gastmeier Petra ,   the PROHIBIT study group
Published: May 2018

Introduction
Hospitals from 24 European countries were asked for information on infection prevention and control (IPC) indicators as part of the Prevention of Hospital Infections by Intervention and Training (PROHIBIT) survey. Methods: Leading IPC personnel of 297 hospitals with established healthcare-associated infection (HCAI) surveillance provided information on local surveillance and feedback by using a questionnaire. Results: Most hospitals focused on bloodstream infection (BSI) (n = 251) and surgical site infection (SSI) (n = 254), with a SSI post-discharge surveillance in 148 hospitals. As part of the HCAI surveillance, meticillin-resistant Staphylococcus aureus (MRSA) was the leading multidrug-resistant organism (MDRO) under surveillance. Seventy-nine per cent of hospitals (n = 236) monitored alcohol-based hand rub (ABHR) consumption. Feedback to the local IPC committees mainly included outcome data on HCAI (n = 259; 87%) and MDRO among HCAI (n = 245; 83%); whereupon a feedback of MDRO data depended on hospital size (p = 0.012). Discussion/conclusion: Objectives and methods of surveillance vary across Europe, with BSI, SSI and MRSA receiving considerably more attention than indicators such as pneumonia and urinary tract infection, which may be equally important. In order to maximise prevention and control of HCAI and MDRO in Europe, surveillance should be further improved by targeting relevant HCAI. The role of feedback should be explored in more detail.
Tumores Carcinoides do Apêndice Ileocecal: 2 Casos Clínicos
Authors: Alves Magda , Salgueiro, Teresa , Rodrigues Francisco 
Published: May 2018

Em 280 apendicectomias realizadas em 21 meses, foram diagnosticados incidentalmente 2 casos de tumores neuroendócrinos em mulheres com 12 e 89 anos. Ambas foram sujeitas a apendicectomia urgente por clínica de apendicite aguda com 12 horas e 5 dias de evolução respetivamente sem mais sintomatologia. O diagnóstico histológicoda primeira doente foi tumor neuroendócrino com 2 mm de diâmetro e localização incomum, o corpo do apêndice. Na segunda doente um tumor de 1,5 cm no apex. Em ambas, dada a localização, o tamanho tumoral e margens livres, a apendicectomia foi curativa. Da análise dos dados e segundo a literatura, verificou-se que estes tumores são os mais frequentes no apêndice, ocorrendo principalmente em mulheres e com localizações mais comuns no apex e base seguindo-se o corpo.
Recebido: 29/07/2015 – Aceite: 04/01/2016
Tratamento do Carcinoma da Próstata Metastizado: Surgimento de Novos Horizontes Terapêuticos
Authors: Mota Paulo , Morais Nuno , Torres João Pimentel , Cordeiro Agostinho , Dias Emanuel , Alves Mário Cerqueira , Lima Estevão 
Published: May 2018

A evolução no tratamento do carcinoma da próstata metastizado proporciona atualmente ao Urologista uma vasta gama de possibilidades terapêuticas que comprovadamente melhoram a sobrevida e a qualidade de vida dos doentes. É apresentado um caso clínico neste artigo onde é patente não só a eficácia destas terapêuticas mas também a sua rápida evolução.
Recebido: 27/05/2016 - Aceite: 07/06/2016
Rolf Stahel & Dirk Arnold: Trends in Lung Cancer Treatment and Key Roles of Comprehensive Cancer Centers
Authors: Arnold Dirk , Stahel Rolf , Marques Ana Filipa 
Published: May 2018

On 7th of July 2016, the Update Clinical Oncology event of the Instituto CUF de Oncologia (ICO), organized by Academia CUF at NOVA Medical School, brought together Dirk Arnold and Rolf Stahel, both medical doctors specialized in oncology, to discuss the latest treatment trends and challenges in lung cancer as well as to discuss the key roles and features of benchmarked Cancer Centers.
Received: 23/08/2016 - Accepted: 31/08/2016