bluuebunny/crossref_metadata_2025_split huggingface dataset:
Influence of Marmix premix on the state of lipid peroxidation and indices of non-specific resistance of the organism of pregnant mares with microelementosis
Authors: Shcherbatyy A. R. , Slivinska L. G. , Gutyj B. V. , Fedorovych V. L. , Lukashchuk B. O. 
Published: June 2019

We observed the processes of lipid peroxidation, characterized by increased content of intermediate and its end products (diene conjugates, lipid hydroperoxides, malonic dialdehyde), in the blood of the pregnant mares. The changes of the data of indicators in the organism of the mares at the 9–11 months of pregnancy were established. The level of diene conjugates in the blood of animals was 3.6 ± 0.12 μmol/l, 33.3 and 44.0%, which was higher compared to non-pregnant mares and mares at 4th month of pregnancy. The concentration of lipid hydroperoxides in the blood of mares increased by 100% and by 42.9% in the blood of non-pregnant mares and mares at 4th month of pregnancy. The concentration of malondialdehyde in the blood of mares increased by 75.0%, 51.2% and 25.0% compared to non-pregnant mares and mares at 4th and 7th month of pregnancy, respectively. The results of our research showed that the mineral-vitamin premix Marmix had a positive influence on the state of lipid peroxidation products, contributed to their lowering in the blood of pregnant mares, which demonstrated antioxidant action and stimulated the function of the immune system. It was established that the bactericidal and lysozyme activity of the blood serum and the concentration of circulating immune complexes increases in the mares with lack of trace elements. It was shown that feeding mares during the 9–11 months of pregnancy with the mineral-vitamin premix Marmix had a positive influence on the state of humoral factors of nonspecific resistance. In particular, the concentration of bactericidal activity of serum increased by 31.0%, lysozyme activity of blood serum – 45.4% and contributed to the decrease of the concentration of circulating immune complexes in serum by 3.8 times. The use of mineral-vitamin premix Marmix during 60 days in feeding pregnant mares caused a restoration of the clinical status, a decrease in the content of lipid peroxidation products.
Influence of fungicides on activities of enzymes of phenolic metabolism in the early stages of formation and functioning of soybean symbiotic apparatus
Authors: Mamenko T. P. , Khomenko Y. O. , Kots S. Y. 
Published: June 2019

We studied the effect of complex seed treatment with fungicides and rhizobium culture on the activity of phenolic metabolism enzymes – polyphenol oxidase and guaiacol peroxidase in the early stages of the formation and functioning of various symbiotic systems Glycine max – Bradyrhizobium japonicum. In the research we used microbiological, physiological, biochemical methods, gas chromatography and spectrophotometry. The objects of the study were selected symbiotic systems formed with the participation of soybean (Glycine max (L.) Merr.), Diamond variety, strains Bradyrhizobium japonicum 634b (active, virulent) and 604k (inactive, highly virulent) and fungicides Maxim XL 035 PS (fludioxonil, 25 g/L, metalaxyl, 10 g/L), and Standak Top (fipronil, 250 g/L, thiophanate methyl, 225 g/L, piraclostrobin, 25 g/L). Before sowing, the seeds of soybean were treated with solutions of fungicides, calculated on the basis of one rate of expenditure of the active substance of each preparation indicated by the producer per ton of seed. One part of the seeds treated with fungicides was inoculated with rhizobium culture for 1 h (the titre of bacteria was 108 cells in 1 ml). The other part of the fungicide-treated seeds was not inoculated by rhizobium culture. As a result of the research, it was revealed that an effective symbiotic system formed with the participation of soybean plants and the active strain rhizobia 634b is characterized by a high level of polyphenol oxidase activity and low guaiacol peroxidase in roots and root nodules in the stages of second and third true leaves. Such changes in the activity of enzymes occurred along with the formation of nodules which actively fixed the molecular nitrogen of the atmosphere. An ineffective symbiotic system (strain 604k) is characterized by an elevated level of polyphenol oxidase activity in the roots and guaiacol peroxidase in the root nodules, which is accompanied by activation of the process of nodulation. Treatment of soybean seeds with fungicides in an effective symbiotic system leads to a change in the activity of the enzymes of the phenolic metabolism, which induced adaptive changes in plant metabolism and growth of nitrogenase activity of the root nodules. The recorded changes in the activity of both enzymes for the action of fungicides in the ineffective symbiotic system can be considered as a kind of response of the plant to the treatment and were observed along with the reduction of the processes of nodulation into the stage of the third true leaf.
Bifidogenic properties of cell-free extracts derived from probiotic strains of Bifidobacterium bifidum and Lactobacillus reuteri
Authors: Knysh O. V. 
Published: June 2019

Comprehensive study of the biological activity of structural components and metabolites of “beneficial” microorganisms opens the prospects of efficient and rational use of their biotechnological potential in the correction of microecological and related disorders. The study tested proliferative activity and biofilm formation by Bifidobacterium bifidum probiotic strain under the influence of cell-free extracts containing structural components and metabolites of the probiotic strains of B. bifidum and Lactobacillus reuteri. Cell-free extracts were obtained by disintegrating suspensions of probiotic cells by cyclic freezing-thawing, cultivating probiotic microorganisms in their own disintegrates and subsequent filtration of the obtained disintegrates and cultures. The proliferative activity and biofilm formation of the probiotic test culture were studied by spectrophotometric microtiter plate method with 10%vol, 30%vol and 50%vol content of cell-free extracts in the cultivation medium. All investigated extracts showed a significant concentration-dependent stimulatory effect on the proliferative activity of B. bifidum. According to the degree of stimulatory effect on the B. bifidum proliferation, cell-free extracts arranged in ascending order: MLG (filtrate of L. reuteri culture, grown in L. reuteri disintegrate supplemented with 0.8 M glycerol and 0.4 M glucose) < MB (filtrate of В. bifidum culture, grown in В. bifidum disintegrate) < B (filtrate of В. bifidum disintegrate) < ML (filtrate of L. reuteri culture, grown in L. reuteri disintegrate) < L (filtrate of L. reuteri disintegrate). With the same content in the culture medium, filtrates of disintegrates had a more pronounced stimulatory effect than filtrates of cultures grown in their own disintegrates. Cell-free extracts from L. reuteri (L and ML) exerted a more pronounced stimulatory effect than cell-free extracts from B. bifidum. Not all studied cell-free extracts stimulated the biofilm formation by B. bifidum. The effect of cell-free extracts on this process depended on their type and concentration. Extract L had a predominantly inhibitory effect on biofilm formation by B. bifidum. The most pronounced stimulatory effect on biofilm formation by B. bifidum came from extract MLG. ML, B and MB extracts stimulated this process approximately equally. The detection of significant bifidogenic effect of the studied cell-free extracts may contribute to their pharmaceutical applications. Cell-free extracts can be used as metabiotics or prebiotics for increasing the survival of the injected probiotic, facilitating its inoculation in the gastrointestinal tract when used together. The obtained data encourage further careful study of the biochemical composition of cell-free extracts and efforts to clarify the mechanism of their action.
A szénhidrát-anyagcsere és a gyulladásos folyamatok jellemzésére szolgáló új marker, a szérumprogranulin diagnosztikai és prognosztikai szerepéről
Authors: Nádró Bíborka , Sztanek Ferenc , Lőrincz Hajnalka , Páll Dénes , Paragh György , Harangi Mariann 
Published: June 2019

Abstract: Progranulin is a recently recognized multifunctional glycopeptide shown to be related to obesity and diabetes mellitus. Progranulin is an endogenous antagonist of tumor necrosis factor-α by competitively binding to its receptor, therefore, it exerts anti-inflammatory activity. Paradoxically, previous studies have shown that serum levels of progranulin were elevated in patients with diabetes and associated to its complications including micro- and macroangiopathies, macroalbuminuria or reduced renal function. Moreover, hyperprogranulinemia may be involved in the pathogenesis of obesity-associated insulin resistance. The review summarizes the currently available data on progranulin as a novel marker of the carbohydrate metabolism and inflammation. Orv Hetil. 2019; 160(25): 973–979.
Cervicalis vertigo – létező kórkép vagy fikció?
Authors: Végh Ildikó , Harmat Kinga , Gerlinger Imre 
Published: June 2019

Abstract: The existence of cervical vertigo is still a question under debate. The basic hypothesis of the disease is that the abnormalities of the neck cause dizziness. The name itself is not accurate, as on the basis of the descriptions we cannot talk about true vertigo. The most common symptoms of cervical vertigo are cervical pain or discomfort, imbalance or dizziness and limitation of cervical movement. The origin of the disease is unclear. Based on the literature, there are four most accepted hypotheses: neurovascular, vascular, proprioceptive theory and migraine-associated cervicogenic vertigo. Of these, the neurovascular theory has already been discredited and its existence is clearly disproved. When diagnosing cervical vertigo, we always face the following difficulties: there is no diagnostic method specific to the disease, pathognomic clinical elements are unavailable, no clear therapeutic recommendation exists. The diagnosis of the disease requires the exclusion of alternatives, but the possibility of the existance of psychogenic vertigo causes further difficulties for the clinicians. Regarding the treatment, the combination of manual therapies and vestibular rehabilitation seems to be the most effective. Orv Hetil. 2019; 160(25): 967–972.
A gluténmentesen táplálkozó fogyasztók életminősége. Magyarországi és romániai kérdőíves felmérés eredményei
Authors: Szűcs Viktória , Fazakas Zita , Farr AnaMaria , Tarcea Monica 
Published: June 2019

Abstract: Introduction and aim: With the rising consumer’s health awareness, especially towards patients with celiac disease, gluten has become a food ingredient to be avoided by many people expecting various positive health effects. The strict adherence of diet requires serious abandonments and lifestyle changes that affect directly their quality of life. The aim of the present study was to recognise the quality of life of Hungarian and Romanian consumers following a gluten-free diet as well as to explore the negative effects on them. Method: An online questionnaire survey was conducted upon 1155 Hungarian and Romanian respondents. Results: For gluten-free consumers, self-control was relatively easy to overcome, but their lifestyle was negatively affected by social events and dining out. In addition, diet adherence was a burden from both lifestyle and financial point of view. For Hungarian consumers, external factors such as price, choice, taste and availability of products had become a major obstacle, while Romanian ones were more likely to be affected by internal factors (product information, diet knowledge, lifestyle, self-control). Mandatory labelling of substances and products causing allergies and intolerances has achieved its purpose, as it has made it easier for consumers on diet to choose food and increased their confidence. Conclusions: The study points out that dieters’ quality of life can be enhanced not only by general actions (improving the preparedness of out-of-home meal services and rationalising the price of products), but also through country-specific community intervention. Orv Hetil. 2019; 160(25): 980–986.
Szemfenéki angioid csíkok szisztémás betegségekben
Authors: Kriskó Dorottya , Popper-Sachetti Andrea , Sallai Ágnes , Sándor Gábor , Nagy Zoltán Zsolt , Szepessy Zsuzsanna 
Published: June 2019

Abstract: Angioid streaks are defined as the special morphological alteration of the fundus; the most common clinical manifestations are irregular, reddish brownish stripes around the optic nerve head or on the posterior pole. On the basis of histological examination, the cause of this phenomenon is the breaks and continuity deficiencies in the thin layer of Bruch membrane caused by the degeneration of elastic fibers. The aim of this study is to present the ocular complication of this rare entity through the description of three cases, and to draw attention to systemic diseases in the background. In our first and third cases, pseudoxanthoma elasticum (Grönblad–Strandberg syndrome) was in the background, while in our second case, hematological disease was confirmed. In our first and second cases, the ocular complication was the choroidal neovascularization, which we treated with intravitreal anti-VEGF injection. In our third case, the choroidal rupture was the ocular complication, caused by trauma. Angioid streaks on the fundus may be sub-phenomena of systemic diseases, the detection, differential diagnosis and treatment require interdisciplinary collaboration between associate physicians. Orv Hetil. 2019; 160(25): 994–1000.
A D3-vitamin-szint és a betegség súlyossága közötti kapcsolat vizsgálata herediter angioödémában
Authors: Visy Beáta , Szilágyi Tamás , Kőhalmi Kinga Viktória , Veszeli Nóra , Varga Lilian , Imreh Éva , Farkas Henriette 
Published: June 2019

Abstract: Introduction: In recent years, many papers analyzed the relationship between serum vitamin D3 level and the frequency and activity of various diseases at least partially attributed to immune mechanisms. Aim: We looked for correlations among the number and location of edematous episodes occurring in patients with hereditary angioedema due to C1-inhibitor deficiency (C1-INH-HAE) and the quantity of the C1-inhibitor used for supplementation as well as the vitamin D3 levels of patients. Method: We measured vitamin D3 levels in 118 of the 175 C1-INH-HAE patients of the National Angioedema Reference Center during the winter–spring (n = 111) and the summer–autumn periods (n = 105) in 2013–2014. Complement levels and clinical data were extracted from the National Angioedema Registry and from patient diaries. Results: The proportion of vitamin D3 deficient patients (serum level <20 ng/ml) was approximately 59.5% during winter–spring, 27.6% in summer–autumn, and 23.5% during both periods. There was a significant difference between vitamin D3 serum levels measured in the winter–spring or in the summer–autumn months (p<0.0001). The same applies to the number of the vials of C1-inhibitor concentrate administered as acute treatment for angioedema attacks (p = 0.01). In any season, vitamin D3 level did not correlate with the number of attacks experienced by the patients during the given period or of the vials of C1-inhibitor concentrate administered. Conclusions: We could not demonstrate a relationship between vitamin D3 level and the frequency or location of edematous episodes in HAE patients. The need for treatment (as reflected by the number of the vials administered) was higher in the winter–spring period. As vitamin D3 deficiency was more severe than expected in our patients, supplementation is clearly necessary. Orv Hetil. 2019; 160(25): 987–993.
The prognostic value of various markers of lower limb atherosclerotic lesions in patients with high and very high cardiovascular risk
Authors: Genkel V. V. , Shaposhnik I. I. 
Published: June 2019

Aim. To study the prognostic significance of various markers of atherosclerosis of lower limb arteries (LLA) in patients at high and very high cardiovascular risk (CVR).Methods. The study included 108 patients at high and very high CVR, the median age of which was 62.0 (55.7; 67.0) years. All patients underwent duplex scanning of the LLA, as well as measurement of the ankle-brachial index (ABI) by the Doppler method. The combined end point was cardiovascular death, nonfatal myocardial infarction or unstable angina, requiring hospitalization, nonfatal stroke, coronary revascularization.Results. Atherosclerotic plaques in LLA were detected in 69.4% of cases, while a decrease in ABI was detected in 22.2% of patients, and LLA stenosis more than 50% in 36.1%. The follow-up duration was 25.0 (14.5; 35.5) months. The adverse cardiovascular events occurred in 41 (37.9%) patients. According to the Cox regression results, the following indicators had an independent predictive value in relation to the development of adverse cardiovascular events: a decrease in ABI ≤0.9 (RR 2.23; 95% CI 1.01-4.94; p=0.048), LLA stenosis ≥40% (RR 3.17; 95% CI 1.27–7.92; p=0.013) and the presence of plaque in the popliteal arteries (RR 2.49; 95% CI 1.27–7.92; p=0.013).Conclusion. In the group of patients at high and very high CVR, among ultrasonographic markers of lower limb arteriosclerosis, independent predictive value regarding the development of adverse cardiovascular events had a decrease in ABI ≤0.9, the presence of plaque in the popliteal arteries and LLA stenosis more than 40%.
Dictionary, Translation and Chinese Language in Domingo Fernández de Navarrete
Authors: Busquets Alemany Anna 
Published: June 2019

<p><span lang="EN-US">One of the essential elements of the much-admired accommodation of the Jesuits was their dedication to the study of the Chinese language. However, this orientation is not exclusively to the Jesuits. The other religious orders also showed the same orientation from the first moment. Although following the imperial guidelines of Nebrija evangelization should be done in Spanish, the friars who left for America and Asia were</span><span><span> </span></span><span>focused from the first moment to learn the local languages. Following the line of sixteenthcentury Mexican dictionaries and languages, the translation of texts between Spanish and Chinese already had a clear representation in the Philippine Islands with the work of Juan Cobo. Throughout the XVII several vocabularies, grammars and language arts would appear while the work of the Dominican Domingo Fernández de Navarrete would include a very brief dictionary. This interest of mendicants by the local languages would culminate in the work of the Dominican Francisco Varo. Starting from the original sources —manuscripts and printed— of the seventeenth century, this communication will analyze in detail the linguistic accommodation of the mendicant orders with special emphasis on the Franciscans and the Dominicans.</span></p>
The Image of the Interpreter in the First Sino-Spanish Contacts (16th Century)
Authors: Béguelin-Argimón Victoria 
Published: June 2019

<span>The earliest Spanish travelers in China coming from the Philippines (16th century), not being able to communicate in Chinese, have to trust interpreters who, very often and for the most diverse reasons, do not always carry out their work with the expected fidelity. These interpreters, beyond being mere translators, also function as guides, as informants about the territory and, above all, as cultural mediators. The first documents on Sino-Spanish contacts, especially Rada’s, Loarca’s, Tordesillas’, and Sánchez’ travel accounts, written between 1575 and 1583, allow to catch a glimpse of the interpreters’ identity, their social and geographical origin, their linguistic and cultural skills, their various</span> <span>tasks in mediation as well as the difficulties<br />they have to deal with in their work. The documents also allow to perceive the need for the first missionaries to learn Chinese and their very first attempts to do so.</span>
Problems in the Translation of Phraseologisms in Bilingual Dictionaries Spanish-Chinese / Chinese-Spanish
Authors: Xiaoxiao Lyu 
Published: June 2019

<p>The phraseology is part of the linguistic studies on phrases, proverbs, idioms, proverbs and other units of syntax totally or partially fixed. It is the reflection of a certain tradition and idiosyncrasy of society. The native speaker recognizes the phraseological units in the praxis of speech without difficulty. However, because of their idiomaticity and the sociocultural divergence between two linguistic communities, Spanish sayings and expressions cannot always be understood by the Chinese speakers. Students of Spanish as a foreign language have difficulty recognizing the non-literal meaning of an expression, the use of this type of expression in language teaching develops communicative competence, linguistics competence, sociolinguistics and pragmatics competence. Then, when producing a bilingual dictionary, it is not enough to translate it into the target language, but rather to contrast the two languages in order to inform non-native speakers of unknown elements, such as historical and cultural backgrounds, uses, and their frequency of application, variants, etc.</p>
Treason by Bilingualism? Xenophobia, Clique, and the Impeachment of Yu Jing
Authors: Yue Isaac 
Published: June 2019

<p>A gifted linguist, diplomat, and negotiator, Yu Jing (1000-1064) is uniquely qualified among Northern Song officials in his extensive knowledge of Khitan language and culture. At a time when Liao-Song relationship was at its most contentious, the advantage of having an official who could communicate fluently in both languages cannot be overstated. However, according to official history, not only did his bilingualism not endear him to the court, it aroused constant suspicion and led to his eventual impeachment, which occurred after he composed a poem in the Khitan language and presented it to the Emperor of the Liao State as a token of gratitude. The purpose of this paper is to reexamine the cause of Yu Jing’s indictment in the context of political machination. By contextualizing his composition of the Poem in the Language of the Barbarian and subsequent impeachment within the politics of the court, my goal is to supplement, even challenge, our above conventional acceptance of xenophobia as the sole cause of Yu’s downfall. In doing so, I hope to point out the potential flaw of our current understanding of Song diplomacy as guilelessly dictated by its inferiority complex and0xenophobic sentiments.</p>
INFECCIÓN URINARIA GESTACIONAL COMO FUENTE DE COMPLICACIONES PERINATALES Y PUERPERALES
Authors: Rodríguez Barraza Wendy Carolina 
Published: June 2019

La infección en la mujer gestante ha demostrado ser una situación de alto riesgo, para el desarrollo y correcto desenlace de la gestación. La proliferación de los diferentespatógenos que se asientan o llegan a colonizar el tracto urinario, sea que se conviertan en una entidad clínica sintomática o no, pueden terminar en complicaciones evitables para el binomio madre-hijo. Con la siguiente revisión se pretende considerar la evidencia disponible acerca de las características y participación de la infección urinaria en la génesis de complicaciones perinatales y puerperales.