bluuebunny/crossref_metadata_2025_split huggingface dataset:
The distribution, clearance, and brainstem toxicity of panobinostat administered by convection-enhanced delivery
Authors: Singleton William G. B. , Bienemann Alison S. , Woolley Max , Johnson David , Lewis Owen , Wyatt Marcella J. , Damment Stephen J. P. , Boulter Lisa J. , Killick-Cole Clare L. , Asby Daniel J. , Gill Steven S. 
Published: June 2018

OBJECTIVEThe pan–histone deacetylase inhibitor panobinostat has preclinical efficacy against diffuse intrinsic pontine glioma (DIPG), and the oral formulation has entered a Phase I clinical trial. However, panobinostat does not cross the blood-brain barrier in humans. Convection-enhanced delivery (CED) is a novel neurosurgical drug delivery technique that bypasses the blood-brain barrier and is of considerable clinical interest in the treatment of DIPG.METHODSThe authors investigated the toxicity, distribution, and clearance of a water-soluble formulation of panobinostat (MTX110) in a small- and large-animal model of CED. Juvenile male Wistar rats (n = 24) received panobinostat administered to the pons by CED at increasing concentrations and findings were compared to those in animals that received vehicle alone (n = 12). Clinical observation continued for 2 weeks. Animals were sacrificed at 72 hours or 2 weeks following treatment, and the brains were subjected to neuropathological analysis. A further 8 animals received panobinostat by CED to the striatum and were sacrificed 0, 2, 6, or 24 hours after infusion, and their brains explanted and snap-frozen. Tissue-drug concentration was determined by liquid chromatography tandem mass spectrometry (LC-MS/MS). Large-animal toxicity was investigated using a clinically relevant MRI-guided translational porcine model of CED in which a drug delivery system designed for humans was used. Panobinostat was administered at 30 μM to the ventral pons of 2 juvenile Large White–Landrace cross pigs. The animals were subjected to clinical and neuropathological analysis, and findings were compared to those obtained in controls after either 1 or 2 weeks. Drug distribution was determined by LC-MS/MS in porcine white and gray matter immediately after CED.RESULTSThere were no clinical or neuropathological signs of toxicity up to an infused concentration of 30 μM in both small- and large-animal models. The half-life of panobinostat in rat brain after CED was 2.9 hours, and the drug was observed to be distributed in porcine white and gray matter with a volume infusion/distribution ratio of 2 and 3, respectively.CONCLUSIONSCED of water-soluble panobinostat, up to a concentration of 30 μM, was not toxic and was distributed effectively in normal brain. CED of panobinostat warrants clinical investigation in patients with DIPG.
Effect of fascicle composition on ulnar to musculocutaneous nerve transfer (Oberlin transfer) in neonatal brachial plexus palsy
Authors: Smith Brandon W. , Chulski Nicholas J. , Little Ann A. , Chang Kate W. C. , Yang Lynda J. S. 
Published: June 2018

OBJECTIVENeonatal brachial plexus palsy (NBPP) continues to be a problematic occurrence impacting approximately 1.5 per 1000 live births in the United States, with 10%–40% of these infants experiencing permanent disability. These children lose elbow flexion, and one surgical option for recovering it is the Oberlin transfer. Published data support the use of the ulnar nerve fascicle that innervates the flexor carpi ulnaris as the donor nerve in adults, but no analogous published data exist for infants. This study investigated the association of ulnar nerve fascicle choice with functional elbow flexion outcome in NBPP.METHODSThe authors conducted a retrospective study of 13 cases in which infants underwent ulnar to musculocutaneous nerve transfer for NBPP at a single institution. They collected data on patient demographics, clinical characteristics, active range of motion (AROM), and intraoperative neuromonitoring (IONM) (using 4 ulnar nerve index muscles). Standard statistical analysis compared pre- and postoperative motor function improvement between specific fascicle transfer (1–2 muscles for either wrist flexion or hand intrinsics) and nonspecific fascicle transfer (> 2 muscles for wrist flexion and hand intrinsics) groups.RESULTSThe patients’ average age at initial clinic visit was 2.9 months, and their average age at surgical intervention was 7.4 months. All NBPPs were unilateral; the majority of patients were female (61%), were Caucasian (69%), had right-sided NBPP (61%), and had Narakas grade I or II injuries (54%). IONM recordings for the fascicular dissection revealed a donor fascicle with nonspecific innervation in 6 (46%) infants and specific innervation in the remaining 7 (54%) patients. At 6-month follow-up, the AROM improvement in elbow flexion in adduction was 38° in the specific fascicle transfer group versus 36° in the nonspecific fascicle transfer group, with no statistically significant difference (p = 0.93).CONCLUSIONSBoth specific and nonspecific fascicle transfers led to functional recovery, but that the composition of the donor fascicle had no impact on early outcomes. In young infants, ulnar nerve fascicular dissection places the ulnar nerve at risk for iatrogenic damage. The data from this study suggest that the use of any motor fascicle, specific or nonspecific, produces similar results and that the Oberlin transfer can be performed with less intrafascicular dissection, less time of surgical exposure, and less potential for donor site morbidity.
The R-Process Alliance: 2MASS J09544277+5246414, the Most Actinide-enhanced R-II Star Known
Authors: Holmbeck Erika M. , Beers Timothy C. , Roederer Ian U. , Placco Vinicius M. , Hansen Terese T. , Sakari Charli M. , Sneden Christopher , Liu Chao , Lee Young Sun , Cowan John J. , Frebel Anna 
Published: June 2018

Abstract
We report the discovery of a new actinide-boost star, 2MASS J09544277+5246414, originally identified as a very bright (V = 10.1), extremely metal-poor ([Fe/H] = −2.99) K giant in the LAMOST survey, and found to be highly r-process-enhanced (r-II; [Eu/Fe] = +1.28]), during the snapshot phase of the R-Process Alliance (RPA). Based on a high signal-to-noise ratio (S/N), high-resolution spectrum obtained with the Harlan J. Smith 2.7 m telescope, this star is the first confirmed actinide-boost star found by RPA efforts. With an enhancement of [Th/Eu] = +0.37, 2MASS J09544277+5246414 is also the most actinide-enhanced r-II star yet discovered, and only the sixth metal-poor star with a measured uranium abundance ([U/Fe] = +1.40). Using the Th/U chronometer, we estimate an age of 13.0 ± 4.7 Gyr for this star. The unambiguous actinide-boost signature of this extremely metal-poor star, combined with additional r-process-enhanced and actinide-boost stars identified by the RPA, will provide strong constraints on the nature and origin of the r-process at early times.
Association of Physical Activity with Late-life Mobility Limitation among Women with Total Joint Replacement for Knee or Hip Osteoarthritis
Authors: Shadyab Aladdin H. , Eaton Charles B. , Li Wenjun , LaCroix Andrea Z. 
Published: June 2018

Objective.To examine the association between leisure-time physical activity (PA) and survival to age 85 with mobility limitation or death before age 85 after total knee (TKR) or total hip replacement (THR) for osteoarthritis (OA).Methods.This was a prospective study among participants from the Women’s Health Initiative (WHI), recruited 1993–1998 (baseline age 65–79 yrs) and followed through 2012. Medicare claims data were linked to WHI data to determine TKR (n = 1986) and THR (n = 1034). Self-reported PA was collected before total joint replacement (TJR).Results.Women who were physically inactive before THR had the highest risk of mobility limitation at age 85 (OR 2.36, 95% CI 1.30–4.26) compared with women who had the highest amount of PA [> 17.42 metabolic equivalent of task (MET)-hrs/week]. Women who reported no moderate to vigorous PA (MVPA) before THR had the strongest risk of mobility limitation (OR 2.00, 95% CI 1.24–3.22) compared with women with the highest level of MPVA (≥ 15 MET-hrs/week). Women who were physically inactive before TKR had the highest risk of mobility limitation (OR 1.68, 95% CI 1.15–2.45) compared with women who had the highest PA level. Women who reported no MVPA before TKR had the strongest risk of mobility limitation (OR 1.60, 95% CI 1.16–2.19) compared with women with the highest level of MPVA. There were significant dose-response associations of lower PA levels with increased risk of late-life mobility limitation and death.Conclusion.Women with lower PA levels before TJR were more likely to experience mobility limitation in late life following TJR for hip or knee OA.
L’attribution de droits réels aux occupants du domaine public : une reformulation a-propriétariste
Authors: Grosdidier Jean 
Published: June 2018

L’analyse fonctionnelle proposée ici au sujet des droits réels attribués à l’occupant du domaine public distinguera la notion de propriété et ces droits réels. Elle permet alors de reformuler la question de leur conformité avec le domaine public. Finalement, seule l’occupation doit être compatible avec l’affectation. Ayant pour but de permettre ce qui est strictement nécessaire à l’occupation effective, l’attribution de droits réels et les opérations postérieures éventuellement effectuées à partir de celui-ci doivent simplement ne pas mettre à mal cette compatibilité. Ainsi devrait pouvoir s’expliquer la compétence de l’autorité administrative sur ces droits réels et le contrôle de son exercice par le juge administratif. Les droits réels en dehors de leur fonction ne devraient alors plus pouvoir être imputés sur le titre, leur validité ne pourrait plus être soutenue dans l’abstrait. Ces droits réels, libérés de l’essentialisme des notions, apparaissent cantonnés à leur fonction de valorisation de l’occupation du domaine public. À chercher à leur faire dire autre chose, on en perd leur signification ?
Jules Soury (1842-1915), traducteur de Ernst Haeckel
Authors: Bossi Laura 
Published: June 2018

Chartiste parisien, Jules-Auguste Soury (1842-1915) a traduit en français trois ouvrages de l’éminent zoologue darwiniste allemand Ernst Haeckel (1834-1919) : Les Preuves du transformisme (Germer Baillière, 1879), Le Règne des protistes (Reinwald, 1879) et Essais de psychologie cellulaire (Germer Baillière, 1880). Les archives du Ernst-Haeckel-Haus à Iéna conservent trente-cinq lettres inédites adressées par Soury à Haeckel entre 1878 et 1914. Ce corpus permet de suivre quelques étapes clés de la vie de Soury, comme l’échec de « sa » chaire d’Histoire des Religions au Collège de France et sa nomination par son mentor Paul Bert à l’École des Hautes Études, où il enseignera l’histoire de la psychologie physiologique et rédigera son opus magnum, Le Système nerveux central (1899) ; il confirme par ailleurs l’interprétation rigidement mécaniste, matérialiste et athée des théories haeckeliennes par Soury, déjà évidente dans les longues préfaces qu’il rédige pour ses traductions. Ces lettres illustrent également l’évolution des relations entre le traducteur et l’auteur, allant de l’admiration à la déception. Lorsque Haeckel lui envoie son livre Der Monismus, Soury rédigera une virulente lettre de rupture (27 décembre 1892), dans laquelle il affirme ne plus pouvoir suivre le maître dans sa nouvelle religion moniste, « avec sa trinité du Beau, du Vrai, du Bien ». Dans sa dernière lettre, envoyée en 1914 à l’occasion du 80e anniversaire de Haeckel, après un long intervalle et juste avant l’éclatement de la Grande Guerre, Soury évoquera toutefois le souvenir nostalgique du temps passé à ses traductions, de celles qui furent « ses meilleures heures, des heures de travail et de méditation ».
L’âme cellulaire et l’ésotérisme moderne de Haeckel
Authors: Erdbeer Robert Matthias 
Published: June 2018

L’analyse suivante porte sur le style, l’écriture et les stratégies de l’ésotérisme moderne. On y analyse des formes hybrides de la Weltanschauung et la manière dont certains auteurs complètent, évaluent, perfectionnent et défient les méthodes des sciences naturelles. La thèse principale est que l’ésotérisme moderne ouvre la voie pour une « épistémologie alternative » ou une « contre-science » (Parawissenschaft) qui constitueraient à la fois un pôle opposé aux sciences et leur plus proche allié. Ernst Haeckel a été admiré et détesté comme un des principaux représentants d’une telle « contre-science » au xixe siècle. Il a fondé ses idées d’une morphologie darwinienne et d’un monisme philosophique sur une terminologie proprement « alternative ». Cet article traite de son concept de la « cytopsyché » (Zellseele, l’âme cellulaire) et du discours dans lequel il est formulé. Ces « cellules de l’âme » apparaissent comme les arcanes d’une subtile architecture moniste, mais révèlent aussi une écriture populaire et évocatrice.
Une manufacture de céramique vue à travers ses déchets : expérience pluridisciplinaire autour d’un dépotoir
Authors: Bonnot Thierry 
Published: June 2018

En France, l’archéologie industrielle s’est développée à partir des années 1970. Dans ce domaine, les opérations de fouilles demeurent assez rares, l’essentiel des recherches portant sur le bâti encore en élévation. Cet article retrace une expérience de fouille archéologique du contemporain, menée en Bourgogne, dans le dépotoir d’une entreprise de fabrication céramique daté du xxe siècle, montrant que la problématique du déchet industriel est d’un intérêt considérable pour l’archéologie comme pour les autres sciences humaines, dont l’anthropologie.
L’archéologie de la Grande Guerre : une nécessaire interdisciplinarité
Authors: Landolt Michaël 
Published: June 2018

Les vestiges de la Grande Guerre sont désormais pris en considération par les archéologues. Bien qu’opportuniste à ses débuts, à la fin des années 1980, l’archéologie du premier conflit mondial a su développer des problématiques scientifiques à travers différentes approches. Au moment où s’éteignait le dernier vétéran du conflit, en 2011, la découverte du « Pompéi de la Grande Guerre » à Carspach (Haut-Rhin) a permis de mettre au jour un vaste abri souterrain où vingt et un soldats allemands avaient été ensevelis en mars 1918. Cette fouille a déclenché de nombreuses réflexions méthodologiques pluridisciplinaires autour de la discipline archéologique.
L’âge de la Corne (1882-1887) : analyse historique, épistémologique et archéologique d’un production suisse de falsifications lacustres
Authors: Lehmann Cloé 
Published: June 2018

L’âge de la Corne correspond à une production de faux archéologiques en os et en bois de cerf, polis et décorés de motifs géométriques caractéristiques. Ceux-ci ont été réalisés dans les années 1880 sur les rives du lac de Neuchâtel (Suisse) lors d’une intense phase d’exploitation des sites palafittiques. Ce phénomène, représentatif du développement et du succès des falsifications lacustres à la fin du xixe siècle, est ici étudié selon trois angles d’analyse : l’histoire, l’épistémologie et l’archéologie.
Improvement of Nutritional Intake in Intensive Care Unit Patients via a Nurse-Led Enteral Nutrition Feeding Protocol
Authors: Orinovsky Ira , Raizman Ela 
Published: June 2018

BackgroundEnteral nutrition in intensive care unit patients has important prognostic clinical value. Feeding protocols are recommended by clinical practice guidelines as a key strategy to maximize the benefits and minimize the risks of enteral feedings.ObjectiveTo examine whether enteral nutrition in critically ill patients could be improved by implementation of a nurse-led evidence-based feeding protocol.MethodsAn interprofessional group of intensive care unit nurses, physicians, and a clinical dietitian designed a protocol to address and correct the shortcomings of enteral feeding. Data on feeding and clinical outcomes were collected retrospectively for patients for 12 months before (control group) and then for 12 months after (interventional group) implementation of the protocol.ResultsEnteral feeding was started significantly earlier (P = .007) after admission to the intensive care unit in the intervention group (52.3 hours; SD, 42.6) than in the control group (70.3 hours; SD, 65.2). Use of the protocol resulted in a significant increase in nutritional intake; 90% of patients in the intervention group but only 34% in the traditional feeding group achieved their caloric target within 96 hours after admission (P &lt; .001). After implementation of the protocol, cessation of feeding due to intolerance was significantly less (P = .03) in the intervention group (6%) than in the traditional feeding group (14 %), and no adverse events were detected.ConclusionsAdherence to standardized guidelines with a written protocol for an early start and timely escalation of enteral feeding can improve nutritional intake among intensive care unit patients.
Morphology of antennae ofDendroctonus vitei(Coleoptera: Curculionidae: Scolytinae), with special reference to sensilla clustered into pit craters
Authors: López María Fernanda , Armendáriz-Toledano Francisco , Albores-Medina Arnulfo , Zúñiga Gerardo 
Published: June 2018

AbstractAs reported recently by the authors, the third and fourth antennomeres of the antennal club of the bark beetleDendroctonus viteiWood (Coleoptera: Curculionidae: Scolytinae) possess conoid sensilla clustered inside spherical or bulb-shaped invaginations of the cuticle that resemble geological pit craters. These structures are novel relative to otherDendroctonusErichson species examined. The morphology and ultrastructure of different sensilla types on the antennal club and within the pit craters ofD. viteiare herein described in detail with the aid of light, environmental scanning electron, and transmission electron microscopy. Five types of sensilla were found: fluted, basiconica type I, and trichodea types I, II, and III. The pit craters were composed of clusters of multiporous sensilla basiconica arising from the inner surface of the concavities, and the morphology and ultrasructure of these sensilla are consistent with an olfactory function. The presence of pit craters in theD. viteion the anterior side of the antennal club is an diagnostic character for this species and an autapomorphy of great taxonomic importance within theDendroctonus frontalisZimmermann species complex.
Quantification of Whey Protein Content in Milk-Based Infant Formula Powders by Sodium Dodecyl Sulfate–Capillary Gel Electrophoresis (SDS-CGE): Multilaboratory Testing Study, Final Action 2016.15
Authors: Feng Ping , Fuerer Christophe , McMahon Adrienne ,   Collaborators:, Arendse K , Chanady A , Chen H , Chen W , Ding X , Gao T , Huang K , Jenni R , Leng X , Li L , Manti V , Pan J , Questa S , Shi X , Sung M , Wang G , Wang S , Wang X , Wang Y , Wu L , Yan S , Yang Y , Yang Y , Yu Y , Zhang C , Zhang H , Zhang X , Zheng K , Zhou J 
Published: June 2018

Abstract
A multilaboratory testing study was conducted on AOAC First Action Official Method SM 2016.15: Quantification of Whey Protein Content in Infant Formula Powders by Sodium Dodecyl Sulfate–Capillary Gel Electrophoresis (SDS-CGE). Nineteen laboratories participated in the analysis of duplicate blind-coded samples of 15 formula powder products for infants and young children. Electrophoregrams were recorded at UV220 nm and integrated. The normalized peak areas of whey and casein proteins were summed separately to calculate total whey protein content. Apart from one sample [NIST Standard Reference Material (SRM) 1849a], relative standard deviation of repeatability (RSDr) and reproducibility (RSDR) ranged from 0.83 to 2.11% and from 2.18 to 4.22%, respectively, and Horwitz ratios ranged from 1.02 to 1.85, meeting the precision limits specified in the whey protein Standard Method Performance Requirements and in the guidelines recommended for the Horwitz ratio. In these samples, the measured whey protein content was between 98 and 108% of the declared value. NIST SRM 1849a showed atypical results, with elevated RSDr (3.51%), RSDR (5.94%), Horwitz ratio (2.62), and recovery (134%). There is no clear reason for this. The percent whey protein value for NIST is calculated from the formulation and is not a reference or certified value. Multiple instrument models and makes, as well as capillary sources, were used in this collaborative study, demonstrating the robustness of the method. The method is fit-for-purpose for the quantification of whey protein content in milk-based formula powder products for infants and young children. It is not applicable to the analysis of hydrolyzed or plant protein–based infant formulas.
COMPETENCIA MEDIÁTICA Y NECESIDADES DE ALFABETIZACIÓN AUDIOVISUAL DE DOCENTES Y FAMILIAS ESPAÑOLAS
Authors: González-Fernández Natalia , Ramírez-García Antonia , Salcines Talledo Irina 
Published: June 2018

El contexto familiar y educativo ejerce una gran influencia en los jóvenes de la sociedad del siglo xxi, siendo necesaria una alfabetización mediática para relacionarse crítica y eficazmente con los medios y sus mensajes. Tanto las familias como los educadores precisan ser competentes mediáticamente para poder ser un modelo personal, profesional y social ante los menores sobre cómo acceder reflexiva y constructivamente a la información y el conocimiento a través de los medios. Por lo tanto, el principal objetivo de esta investigación se centra en conocer el panorama actual en relación con la competencia mediática de familias y docentes españoles. Este estudio se enmarca en un proyecto I+D+i financiado por el gobierno español. Con la finalidad de dar respuesta al objetivo mencionado, se han llevado a cabo análisis estadísticos descriptivos y de significación a partir de las respuestas de 905 docentes de diferentes etapas educativas (Infantil, Primaria, Secundaria, Bachillerato y Formación Profesional) de diez provincias españolas a un cuestionario, diseñado y validado ad hoc, como técnica cuantitativa para la recogida de información. Por otro lado, se han analizado cualitativamente los resultados de nueve Focus Group (FG) desarrollados en nueve provincias españolas, en los que participaron un total de 51 padres y madres de jóvenes estudiantes menores de edad. Los principales resultados de la investigación reflejan que los docentes presentan un alto grado de formación en competencia mediática y hacen un uso pedagógico de los medios, mientras que las familias reconocen y justifican determinadas carencias al respecto. Sin embargo, ambos colectivos han adquirido un rol prosumidor y reflejan ciertas demandas y necesidades formativas.
EMPLOYABILITY OF RECENT GRADUATES. OPINIONS OF CATALONIAN COMPANIES AND INSTITUTIONS
Authors: Guàrdia-Olmos Joan , Peró-Cebollero Maribel , Martínez-Ricart Mar , Cañete-Massé Cristina , Turbany-Oset Jaume , Berlanga-Silvente Vanesa 
Published: June 2018

Introduction: Labor insertion for young people is probably more difficult nowadays than it was a few decades ago in all productive sectors and in academic education. A few decades ago, having a university degree was a guarantee of quick labor insertion, but nowadays, although having a university degree may somewhat alleviate the unemployment rate, it is still high among recent university graduates. In this paper, we show the differential profile of the companies who do hire recent graduates as compared to those who do not.Methodology: We worked with a sample of 1,325 employers from the business world of Catalonia, who were administered the questionnaire prepared adhoc during 2014. Results: The main results show that the more workers a company has, the higher the probability that they will hire recent graduates. Companies with a high percentage of graduated workers are more likely to hire recent graduates. Companies who are willing to work with Agency for the Quality of the University System of Catalonia hire more than those who are not. And finally, the service sector hires more than construction or industry.Conclusions: In the present study we have shown a differential pattern between the companies that hire recent graduates or not, a very important aspect because this could help define university policies to facilitate the transition to the labor market.