bluuebunny/crossref_metadata_2025_split huggingface dataset:
Faktor-faktor yang Berhubungan dengan Perilaku Pemeriksaan Payudara Sendiri (SADARI) pada Mahasiswi Fakultas Kedokteran Universitas Pembangunan Nasional “Veteran” Jakarta, 2017
Authors: Khairunnissa Aulia , Wahyuningsih Sri 
Published: February 2019

Kanker merupakan salah satu penyebab utama kematian. Estimasi insiden kanker payudara di Indonesia sebesar 36 per 100.000 perempuan. Lebih dari 80% kasus ditemukan berada pada stadium yang lanjut. Salah satu cara untuk mengurangi angka kejadian kanker payudara adalah dengan melakukan pemeriksaan payudara sendiri (SADARI). Deteksi dini dapat menekan angka kematian sebesar 25-30%. Penelitian ini dilakukan untuk mengetahui faktor-faktor yang berhubungan dengan perilaku pemeriksaan payudara sendiri (SADARI) pada mahasiswi Fakultas Kedokteran UPN “Veteran” Jakarta tahun 2017. Penelitian ini menggunakan desain cross sectional, menggunakan kuesioner dengan sampel 108 orang. Metode pengambilan sampel menggunakan metode probability sampling dengan teknik proportionate stratified random sampling. Hasil analisis menggunakan uji Chi-square menunjukkan adanya hubungan antara BMI, sumber informasi, sikap, pengetahuan dan dukungan keluarga dengan perilaku pemeriksaan payudara sendiri (SADARI). Tidak ada hubungan antara riwayat penyakit keluarga, umur dan pendapatan dengan perilaku pemeriksaan payudara sendiri (SADARI). Hasil analisis regresi logistik menunjukkan faktor yang paling dominan mempengaruhi perilaku pemeriksaan payudara sendiri (SADARI) adalah pengetahuan (OR=10,889). Kata kunci : kanker payudara, pengetahuan, perilaku, SADARI
A Two-sided Loop X-Ray Solar Coronal Jet Driven by a Minifilament Eruption
Authors: Sterling Alphonse C. , Harra Louise K. , Moore Ronald L. , Falconer David A. 
Published: February 2019

Abstract
Most of the commonly discussed solar coronal jets are the type that consist of a single spire extending approximately vertically from near the solar surface into the corona. Recent research supports that eruption of a miniature filament (minifilament) drives many such single-spire jets and concurrently generates a miniflare at the eruption site. A different type of coronal jet, identified in X-ray images during the Yohkoh era, are two-sided loop jets, which extend from a central excitation location in opposite directions, along low-lying coronal loops that are more-or-less horizontal to the surface. We observe such a two-sided loop jet from the edge of active region (AR) 12473, using data from Hinode X-Ray Telescope (XRT) and Extreme Ultraviolet Imaging Spectrometer (EIS), and from Solar Dynamics Observatory’s (SDO) Atmospheric Imaging Assembly (AIA) and Helioseismic and Magnetic Imager (HMI). Similar to single-spire jets, this two-sided loop jet results from eruption of a minifilament, which accelerates to over 140 km s−1 before abruptly stopping after striking an overlying nearly horizontal-loop field at ∼30,000 km in altitude and producing the two-sided loop jet. An analysis of EIS raster scans shows that a hot brightening, consistent with a small flare, develops in the aftermath of the eruption, and that Doppler motions (∼40 km s−1) occur near the jet formation region. As with many single-spire jets, the magnetic trigger here is apparently flux cancelation, which occurs at a rate of ∼4 × 1018 Mx hr−1, broadly similar to the rates observed in some single-spire quiet-Sun and AR jets. An apparent increase in the (line-of-sight) flux occurs within minutes of the onset of the minifilament eruption, consistent with the apparent increase being due to a rapid reconfiguration of low-lying fields during and soon after the minifilament-eruption onset.
A Hypothetical Effect of the Maxwell–Proca Electromagnetic Stresses on Galaxy Rotation Curves
Authors: Ryutov D. D. , Budker Dmitry , Flambaum V. V. 
Published: February 2019

Abstract
Maxwell–Proca electrodynamics corresponding to finite photon mass causes a substantial change in the Maxwell stress tensor, and under certain circumstances, may cause electromagnetic stresses to act effectively as “negative pressure.” This paper describes a model where this negative pressure imitates gravitational pull and may produce forces comparable to gravity and may even become dominant. The effect is associated with random magnetic fields with correlation lengths exceeding the photon Compton wavelength. The stresses act predominantly on the interstellar gas and cause an additional force pulling the gas toward the center and toward the galactic plane. Stars do not experience any significant direct force but get involved in this process via a “recycling loop,” where rapidly evolving massive stars are formed from the gas undergoing galactic rotation and then lose their mass back to the gas within a time shorter than roughly 1/6 of the rotation period. This makes their dynamics inseparable from that of the rotating gas. As soon as the lighter, slowly evolving stars are formed, they lose their connection to the gas and are only gravitationally confined within the galaxy. Peculiarities in the dynamics of these slowly evolving stars may serve as an experimental test of the presence and magnitude of the Maxwell–Proca stresses. In fact, observational data for Sun-like stars in our galaxy appear to be incompatible with the assumption of the Maxwell–Proca stresses contributing at a level needed to explain the galactic rotation curve, although they could contribute a 10%–20% addition to the observed centripetal pull. It may be interesting to also explore possible broader cosmological implications of the negative-pressure model.
Ultra-wideband Detection of 22 Coherent Radio Bursts on M Dwarfs
Authors: Villadsen Jackie , Hallinan Gregg 
Published: February 2019

Abstract
Coherent radio bursts detected from M dwarfs have some analogy with solar radio bursts but reach orders of magnitude higher luminosities. These events trace particle acceleration, powered by magnetic reconnection, shock fronts (such as those formed by coronal mass ejections (CMEs)), and magnetospheric currents, in some cases offering the only window into these processes in stellar atmospheres. We conducted a 58 hr ultra-wideband survey for coherent radio bursts on five active M dwarfs. We used the Karl G. Jansky Very Large Array to observe simultaneously in three frequency bands covering a subset of 224–482 MHz and 1–6 GHz, achieving the widest fractional bandwidth to date for any observations of stellar radio bursts. We detected 22 bursts across 13 epochs, providing the first large sample of wideband dynamic spectra of stellar coherent radio bursts. The observed bursts have diverse morphology, with durations ranging from seconds to hours, but all share strong (40%–100%) circular polarization. No events resemble solar Type II bursts (often associated with CMEs), but we cannot rule out the occurrence of radio-quiet stellar CMEs. The hours-long bursts are all polarized in the sense of the x-mode of the star’s large-scale magnetic field, suggesting that they are cyclotron maser emission from electrons accelerated in the large-scale field, analogous to auroral processes on ultracool dwarfs. The duty cycle of luminous coherent bursts peaks at 25% at 1–1.4 GHz, declining at lower and higher frequencies, indicating source regions in the low corona. At these frequencies, active M dwarfs should be the most common galactic transient source.
Implementing Dust Shielding as a Criteria for Star Formation
Authors: Byrne Lindsey , Christensen Charlotte , Tsekitsidis Marios , Brooks Alyson , Quinn Tom 
Published: February 2019

Abstract
Star formation is observed to be strongly correlated to dense regions of molecular gas. Although the exact nature of the link between star formation and molecular hydrogen is still unclear, some have suggested that shielding of dense gas by dust grains is the key factor enabling the presence of both. We present a subgrid model for use in galaxy formation simulations in which star formation is linked explicitly to local dust shielding. We developed and tested our shielding and star formation models using smoothed particle hydrodynamic simulations of solar and subsolar metallicity isolated Milky Way–mass disk galaxies. We compared our dust-shielding-based star formation model to two other star formation recipes that used gas temperature and H2 fraction as star formation criteria. We further followed the evolution of a dwarf galaxy within a cosmological context using both the shielding and H2-based star formation models. We find that the shielding-based model allows for star formation at higher temperatures and lower densities than a model in which star formation is tied directly to H2 abundance, as requiring H2 formation leads the gas to undergo additional gravitational collapse before star formation. However, the resulting galaxies are very similar for both the shielding and H2-based star formation models, and both models reproduce the resolved Kennicutt–Schmidt law. Therefore, both star formation models appear viable in the context of galaxy formation simulations.
Following the Cosmic Evolution of Pristine Gas. III. The Observational Consequences of the Unknown Properties of Population III Stars
Authors: Sarmento Richard , Scannapieco Evan , Côté Benoit 
Published: February 2019

Abstract
We study the observational consequences of several unknown properties of Population III stars using large-scale cosmological simulations that include a subgrid model to track the unresolved mixing of pollutants. Varying the value of the critical metallicity that marks the boundary between Population III and Population II star formation across 2 dex has a negligible effect on the fraction of Population III stars formed and the subsequent fraction of Population III flux from high-redshift galaxies. However, adopting a lognormal initial mass function (IMF) for Population III stars, in place of a baseline Salpeter IMF, results in a Population III star formation rate density that is 1/4 of the baseline rate. The flux from high-redshift galaxies modeled with this IMF is highly bimodal, resulting in a tiny fraction of z ≤ 8 galaxies with more than 75% of their flux coming from Population III stars. However, at z = 9, right before reionization in our simulations, ≈20% of galaxies are Population III-bright with

mag, and at least 75% of their flux is generated by Population III stars. Additionally, the lognormal Population III IMF results in a population of carbon-enhanced, metal-poor stars in reasonable agreement with MW halo observations. Our analysis supports the conclusion that the Population III IMF was dominated by stars in the 20–120

range that generate supernovae with carbon-enhanced ejecta.
Predictions for the Detection and Characterization of Galactic Disk Microlensing Events by LSST
Authors: Sajadian Sedighe , Poleski Radosław 
Published: February 2019

Abstract
The upcoming Large Synoptic Survey Telescope (LSST) survey will provide an unprecedented opportunity for studying populations of intrinsically faint objects using microlensing. The LSST’s large field of view and aperture allow effective time-series observations of many stars in the Galactic disk and bulge. Here, we combine Galactic models (for

) and simulations of LSST observations to study how observing strategies affect the number and properties of microlensing events detected by LSST. Generally, detectable microlensing events are (a little) longer than events observable with current surveys. In Galactic bulge fields, LSST should detect on the order of 600 microlensing events per square degree as compared to 19 in disk fields. Improving the cadence from 6 to 2 days approximately doubles the number of detectable microlensing events throughout the Galaxy. We develop an Operations Simulator (OpSim)–based simulation to predict the characteristics of detectable microlensing events in different OpSim strategies and compare them. Based on baseline_2018a, minion_1016, and colossus_2664 OpSim simulations, LSST will observe with either 900 or 170 epochs in different observing times and cadences. With worse cadences LSST will detect longer microlensing events of brighter stars with lower blending. Although increasing the observing time from 1 to 10 yr with a fixed number of epochs does not change the total number of microlensing events significantly, the longer observing time lets one discern artificial effects and measure baseline fluxes, parallax, etc. If LSST spends enough time observing near the Galactic plane, then the large number of microlensing events will allow studies of the Galactic distribution of planets and searches for isolated black holes among a wealth of other scientific cases.
Serum Biomarkers for Prediction of Response to Methotrexate Monotherapy in Early Rheumatoid Arthritis: Results from the SWEFOT Trial
Authors: Hambardzumyan Karen , Bolce Rebecca J. , Wallman Johan K. , van Vollenhoven Ronald F. , Saevarsdottir Saedis 
Published: February 2019

Objective.To investigate baseline levels of 12 serum biomarkers that constitute a multibiomarker disease activity test, as predictors of response to methotrexate (MTX) in patients with early rheumatoid arthritis (eRA).Methods.In 298 patients from the Swedish Pharmacotherapy (SWEFOT) clinical trial, baseline serum levels of 12 proteins were analyzed for association with disease activity based on the 28-joint count Disease Activity Score (DAS28) after 3 months of MTX monotherapy using uni-/multivariate logistic regression. Primary outcome was low disease activity (LDA; DAS28 ≤ 3.2).Results.Of 298 patients, 104 achieved LDA after 3 months on MTX. Four of the 12 biomarkers [C-reactive protein (CRP), leptin, tumor necrosis factor receptor I (TNF-RI), and vascular cell adhesion molecule 1 (VCAM-1)] significantly predicted LDA based on stepwise logistic regression analysis. Dichotomization of patients using receiver-operating characteristic curve analysis-based cutoffs for these biomarkers showed significantly higher proportions with LDA among patients with lower versus higher levels of CRP or leptin (40% vs 23%, p = 0.004, and 40% vs 25%, p = 0.011, respectively), as well as among those with higher versus lower levels of TNF-RI or VCAM-1 (43% vs 27%, p = 0.004, and 41% vs 25%, p = 0.004, respectively). Combined score based on these biomarkers, adjusted for known predictors of LDA (smoking, sex, and age), associated with decreased chance of LDA (adjusted OR 0.45, 95% CI 0.32–0.62).Conclusion.Low baseline levels of CRP and leptin, and high baseline levels of TNF-RI and VCAM-1 were associated with LDA after 3 months of MTX therapy in patients with eRA. Combination of these 4 biomarkers increased accuracy of prediction. [Trial registration number: NCT00764725]
Peripheral Lymphocyte Multidrug Resistance Activity as a Predictive Tool of Biological Therapeutic Response in Rheumatoid Arthritis
Authors: Toldi Gergely , Batel Patrizia , Baráth Sándor , Szerémy Péter , Apjok András , Filkor Kata , Szántó Sándor , Szűcs Gabriella , Szamosi Szilvia , Häupl Thomas , Grützkau Andreas , Szekanecz Zoltán 
Published: February 2019

Objective.Multidrug resistance (MDR) transporters may be used as biomarkers to monitor disease progression in RA and as a predictive tool to establish responsiveness to biological therapy. In this multicenter clinical trial, we aimed to assess the predictive value of activity measurement of transporters MDR1, MD resistance protein (MRP)1, and breast cancer resistance protein (BCRP) for biological therapeutic response in RA before the initiation of biological therapy as well as 4 to 6 and 12 weeks after.Methods.Peripheral blood samples were collected from 27 responders and 12 nonresponders to biological disease-modifying antirheumatic drugs (bDMARD) at the indicated timepoints as well as from 35 healthy controls. MDR activity factor (MAF) of MDR1, MRP1, and BCRP was measured in CD3+ and CD19+ cells using the Solvo MDQ Kit and cell surface staining by flow cytometry following peripheral blood mononuclear cells isolation.Results.At the start of therapy, MAFC (composite MAF of MRP1 and MDR1) and MAFMDR values, and at 4 to 6 weeks of treatment, MAFC, MAFMRP, and MAFMDR values of CD3 cells were higher in nonresponders compared to responders. Receiver-operation characteristic curve analysis revealed that RA patients with MAFC values above 21.3 in CD3 cells at the start of bDMARD therapy are likely to be nonresponders. At 4 to 6 weeks of treatment, these also predict unfavorable response: MAFC values above 20.3, MAFMRP values above 6.0, and MAFMDR values above 13.9 in CD3 cells.Conclusion.Our results indicate that the determination of MAFC values in CD3 cells of patients with RA may be of predictive value prior to the initiation of biological therapy, to establish whether the patient will demonstrate sufficient therapeutic response.
OMERACT Definitions for Ultrasonographic Pathologies and Elementary Lesions of Rheumatic Disorders 15 Years On
Authors: Bruyn George A. , Iagnocco Annamaria , Naredo Esperanza , Balint Peter V. , Gutierrez Marwin , Hammer Hilde B. , Collado Paz , Filippou Georgios , Schmidt Wolfgang A. , Jousse-Joulin Sandrine , Mandl Peter , Conaghan Philip G. , Wakefield Richard J. , Keen Helen I. , Terslev Lene , D’Agostino Maria Antonietta 
Published: February 2019

Objective.The Outcome Measures in Rheumatology (OMERACT) Ultrasound (US) Working Group (WG) operates research activities for the validation of US as an outcome measurement instrument according to the Filter 2.0 framework.Methods.Original publications on definitions and scoring systems for pathophysiological manifestations and elementary lesions of various rheumatic disorders were reviewed from the onset of the WG research in 2005.Results.Definitions and scoring systems according to new terminology are provided.Conclusion.We have redefined OMERACT US pathology and elementary lesions as well as scoring systems, which are now proposed for OMERACT approval for application in clinical trials.
Assessment of outcome-based integrated design project
Authors: Basir Noordin , Chai Lian Oh , Muhd Salmizi Ja'afar , Shaharin Hamid 
Published: February 2019

Outcome-Based Education (OBE) implementation is one of the qualifying requirements for engineering programme accreditation in Malaysia. Implementation of the OBE in Integrated Design Project (IDP) is essential in producing high quality engineering graduates that are able to meet the challenges especially in the era of Industry 4.0 in Malaysia. IDP is the course offered to the final year students of undergraduate programme in Faculty of Civil Engineering, University Teknologi MARA. This paper presents the mapping of the addressing Course Outcomes (CO) and Programme Outcomes (PO) to the scopes of assessment in a capstone project (CP) for IDP. The explicitness in the measurement of CO and PO in the course is demonstrated. The rubrics for the assessment of CP are also presented. Finally, evaluation of student performance in IDP particularly CP is discussed through a sample analysis of the CO and PO attainments.
Concept cartoon in problem-based learning : A systematic literature review analysis
Authors: Jamal Siti , Ibrahim Nor , Surif Johari 
Published: February 2019

Concept cartoon teaching strategy have the potential to increase creativity and innovation as well as the students' interest in understanding concepts. It is considered as a method that encourages students to continue exploring the issues raised and seeking solutions. This concept cartoon lesson is very suitable to be applied in the field of Science, Technology, Engineering and Mathematics which is often regarded as an abstract and difficult field. Therefore, it is becoming a necessity to see how far the cartoon concept in learning has been implemented in schools. This systematic literature review analysis aims to focus on the similarities and differences such as the objective used, the methodology used and the findings of the study. The study article was selected through a database of various types of journals according to keywords. Keywords used in the search are Concept Cartoon AND comic AND Problem-based learning. The search has been limited between 2009 and 2017. A total of 9 studies have been selected to be analyzed based on the four steps in systematic literature review. The four steps included frame a question, run a search, read the abstract and tittle of individual papers and abstract information from selected set of final articles. The results of the systematic literature review analysis can be concluded on recent research and previous research that cartoon concept teaching strategy is very effective in enhancing creative thinking as well as cultivating students' interest in Science, Technology, Engineering and Mathematics.
Perceived Role-Taking Behavior and Course Grades in Junior Year College Nursing Students
Authors: Moser Rosemarie Scolaro 
Published: February 2019

ABSTRACT
Nursing students at the University of Maryland at Baltimore served as subjects for this study of perceived roletaking behavior. Students were asked to identify fellow students whom they perceived as best being able to take the perspectives or points of view of others, by using a sociometric questionnaire. Results for 39 subjects indicated that those who were seen by their classmates as good role takers, tended to receive higher course grades than other students. The importance of social skills, such as role taking, in the baccalaureate nursing degree program is discussed.
Induction and Therapeutic Targeting of Human NPM1c+ Myeloid Leukemia in the Presence of Autologous Immune System in Mice
Authors: Kaur Mandeep , Drake Adam C. , Hu Guangan , Rudnick Stephen , Chen Qingfeng , Phennicie Ryan , Attar Ricardo , Nemeth Jeffrey , Gaudet Francois , Chen Jianzhu 
Published: February 2019

Abstract
Development of targeted cancer therapy requires a thorough understanding of mechanisms of tumorigenesis as well as mechanisms of action of therapeutics. This is challenging because by the time patients are diagnosed with cancer, early events of tumorigenesis have already taken place. Similarly, development of cancer immunotherapies is hampered by a lack of appropriate small animal models with autologous human tumor and immune system. In this article, we report the development of a mouse model of human acute myeloid leukemia (AML) with autologous immune system for studying early events of human leukemogenesis and testing the efficacy of immunotherapeutics. To develop such a model, human hematopoietic stem/progenitor cells (HSPC) are transduced with lentiviruses expressing a mutated form of nucleophosmin (NPM1), referred to as NPM1c. Following engraftment into immunodeficient mice, transduced HSPCs give rise to human myeloid leukemia, whereas untransduced HSPCs give rise to human immune cells in the same mice. The de novo AML, with CD123+ leukemic stem or initiating cells (LSC), resembles NPM1c+ AML from patients. Transcriptional analysis of LSC and leukemic cells confirms similarity of the de novo leukemia generated in mice with patient leukemia and suggests Myc as a co-operating factor in NPM1c-driven leukemogenesis. We show that a bispecific conjugate that binds both CD3 and CD123 eliminates CD123+ LSCs in a T cell–dependent manner both in vivo and in vitro. These results demonstrate the utility of the NPM1c+ AML model with an autologous immune system for studying early events of human leukemogenesis and for evaluating efficacy and mechanism of immunotherapeutics.