bluuebunny/crossref_metadata_2025_split huggingface dataset:
From therapy to therapeutic: the continuum of trauma-informed care
Authors: O’Hara Claudia A. 
Published: April 2019

AbstractOn 1st July 2015, Out of Home Care (OOHC) services in the Australian Capital Territory (ACT) joined together to form the ACT Together consortium and aimed to improve outcomes for children and young people who are unable to live with their birth families. Within the consortium, the Therapeutic Services Team (TST) steers the evolution of trauma-informed therapeutic practice, a key focus of which is the establishment of therapeutic care. Current research indicates that a holistic therapeutic approach has the greatest impact in supporting a young person to overcome adverse childhood experiences. This leads to the necessity of a therapeutic care system providing input across the whole domain of OOHC, including trauma-informed therapeutic carers. A common issue met by the TST is the lack of clarity regarding the difference between therapeutic intervention and therapy. This paper defines the concepts of therapy and therapeutic care, discusses how this forms a continuum which flows throughout the whole OOHC system and reflects on what support carers require to make the shift to becoming therapeutic carers, including outlining their role in underpinning better outcomes for the children and young people who pass through their doors.
Tectonic and climatic controls on Quaternary fluvial processes and river terrace formation in a Mediterranean setting, the Göksu River, southern Turkey
Authors: Avşin Nurcan , Vandenberghe Jef , van Balen Ronald , Kıyak Nafiye Güneç , Öztürk Tuğba 
Published: April 2019

AbstractClimate and tectonics effect the fluvial evolution of the Mediterranean Mut basin. The basin contains a river terrace staircase of 16 levels (T16–T1) ranging from 365 to 10 m above the current Göksu River in its middle and lower sections. These river terraces records tectonic uplift in the Mut basin. Optically stimulated luminescence (OSL) dating of the fluvial sediments of the youngest terrace (T16) provides a chronology for the assessment of the important impacts of climatic changes. The ages from the youngest river terrace deposits in T16 may be subdivided into two intervals: (1) 239–194.7 ka during the later part of Marine Oxygen Isotope Stage (MIS) 7, implying that the aggradation of T16 started in (the final phase of) this warm period; and (2) 187.9–171 ka during much of MIS 6. Thus, it appears that the Göksu River continued depositing sediment from an interglacial into a glacial time. The differences in climate-driven fluvial evolution between this Mediterranean fluvial system and the classical, well-studied temperate–periglacial river systems in Europe may be the result of different vegetation cover and greater thaw of more intense snowfalls.
Development of two-phase transfer zones during multiphase rifting and their influence on sedimentation in the Baxian Sag, Bohai Bay Basin, northern China
Authors: Ma Bingshan , Qi Jiafu , Ge Jiawang 
Published: April 2019

AbstractWe investigate the formation and deformation of transfer zones and their impact on sedimentation during multiphase rifting using a three-dimensional seismic dataset in the Baxian Sag, the onshore part of the Bohai Bay Basin, northern China. The fault system in the study area is dominated by two arcuate, opposing boundary faults, that is, the Niudong and Maxi faults, which form an S-type fault system which does not link together. The fault system and structural-stratigraphic features between the Eocene and Oligocene syn-rift sequences were distinctly different during the Palaeogene rifting. These differences allow us to identify the two-phase transfer zones: (1) a NW–SE-trending Eocene transfer zone linking the NW-tilted Baxian Block and the SE-tilted Raoyang Block , and (2) the N–S-trending Oligocene transfer zone forming along the central part of the S-type fault system between the two inward kinks, and linking S-tilted and N-tilted fault blocks. The two-phase transfer zones comprise transverse boundary fault segments and fault styles which are related to strike-slip motion. The strike-slip faults occurred in the sequence where the transfer zone formed. The transfer zones significantly influenced the syn-rift sediments, drainage catchments and reservoir properties during the periods when they formed, and the two-phase transfer zones represent favourable positions for hydrocarbon accumulation in the Eocene and Oligocene sequences, respectively.
Contegra versus pulmonary homograft for right ventricular outflow tract reconstruction in newborns
Authors: Falchetti Alessandro , Demanet Hélène , Dessy Hugues , Melot Christian , Pierrakos Charalampos , Wauthy Pierre 
Published: April 2019

AbstractObjectives:Pulmonary homografts are standard alternatives to right ventricular outflow tract reconstruction in congenital heart surgery. Unfortunately, shortage and conduit failure by early calcifications and shrinking are observed for small-sized homografts in younger patients. In neonates, Contegra® 12 mm (Medtronic Inc., Minneapolis, Minnesota, United States of America) could be a valuable alternative, but conflicting evidence exists. There is no published study considering only newborns with heterogeneous pathologies. We retrospectively compared the outcomes of these two conduits in this challenging population.Methods:Patients who underwent a right ventricular outflow tract reconstruction between January 1992 and December 2014 at the Hôpital Universitaire des Enfants Reine Fabiola were included. We retrospectively collected and analysed demographic, echocardiographic, surgical, and follow-up data.Results:Of the 53 newborns who benefited from a right ventricular outflow tract reconstruction during the considered period, 30 received a Contegra 12 mm (mean age 15 ± 8 days), and 23 a small (9–14 mm) pulmonary homograft (mean age 10 ± 7 days). Overall mortality was 16.6% with Contegra versus 17.4% in the pulmonary homograft group (p = 0.98 log-rank). Operative morbidity and early re-operation for conduit failure were not significantly different between the two groups. Mean follow-up in this study is 121 ± 74 months. Survival free from re-operation was not different between the two groups (p = 0.15). Multivariable analysis showed that weight and significant early gradient were factors associated with anticipated conduit failure.Conclusions:Contegra 12 mm is a valid alternative to small pulmonary homografts in a newborn patient population. Trial registration: NCT03348397.
Getting Your Ducks in a Row: The Case for More Inclusive Renegotiations inEU–Poultry Meat (China)
Authors: DEREMER DAVID R. , ORTINO FEDERICO 
Published: April 2019

AbstractThis paper critiques a Panel ruling that was permissive in allowing the EU to exclude China from the renegotiations of several tariff lines of poultry meat and the related allocation of new tariff-rate quotas (TRQs). The EU's basis for exclusion was that China lacked a principal or substantial supplying interest in the modified tariff lines. The Panel's ruling supported China for only two tariff lines in which China eventually served 50% of the EU market after certain SPS measures expired, on the narrow basis that this import increase should have been considered a special factor in the TRQ allocation. The paper argues that the Panel ruled too narrowly by disregarding China's broader claims for a principal or substantial supplying interest. An interpretation consistent with the object and purpose of the GATT supports utilizing a broader set of evidence in China's claim as a principal or substantial supplier for renegotiations of tariff schedules. Allowing nations to use TRQs to prevent emerging markets from achieving a substantial supplying interest is a significant obstacle to the WTO's purpose. The Panel's ruling will be important for future TRQ renegotiations, such as those that would be necessary under Brexit.
Global Travel Time Data Set From Adaptive Empirical Wavelet Construction
Authors: Lai Hongyu , Garnero Edward J. , Grand Stephen P. , Porritt Robert W. , Becker Thorsten W. 
Published: April 2019

AbstractWe present a method for constructing the average waveform shape (hereafter called “empirical wavelet”) of seismic shear waves on an event‐by‐event basis for the purpose of constructing a high‐quality travel time data set with information about waveform quality and shape. A global data set was assembled from 360 earthquakes between 1994 and 2017. The empirical wavelet approach permits documentation of the degree of similarity of every observed wave with the empirical wavelet. We adapt the empirical wavelet to all pulse widths, thus identifying broadened (e.g., attenuated) pulses. Several measures of goodness of fit of the empirical wavelet to each record are documented, as well as signal‐to‐noise ratios, permitting users of the data set to employ flexible weighting schemes. We demonstrate the approach on transversely polarized SH waves and build a global travel time data set for the waves S, SS, SSS, Sdiff, ScS, and ScSScS. Onset arrival times of the waves were determined through a correlation scheme with best‐fitting empirical wavelets. Over 250,000 travel times were picked, from over 1.4 million records, all of which were human‐checked for accuracy via a Portable Document Format (PDF) catalog file making system. Many events were specifically selected to bolster southern hemisphere coverage. Coverage maps show that, while the northern hemisphere is more densely sampled, the southern hemisphere coverage is robust. The travel time data set, empirical wavelets, and all measurement metrics are publicly available and well suited for global tomography, as well as forward modeling experiments.
Decadal Variations in the Winter Beaufort High and the Stratospheric Polar Vortex
Authors: Zhang Minghong , Perrie Will , Long Zhenxia 
Published: April 2019

AbstractWe show that a weakened Beaufort High in late winter is becoming more common since the late 1980s, and this weakening is related to decadal changes in Northern Hemisphere ozone depletion. During this time, the stratospheric polar vortex has experienced a decadal northeastward displacement. Such displacement is associated with the variability of the East Asia‐eastern North America dipole. A positive Asia‐eastern North America dipole leads to zonal asymmetry in the ozone depletion with maximum loss over eastern Eurasia. Positive feedback with the zonally asymmetric ozone loss contributes to increased occurrence of the northeastward displacement of the stratospheric polar vortex. The northeastward displaced polar vortex enhances baroclinicity over the Eurasian Arctic and causes an increase in the frequency and intensity of cyclones and a decrease in anticyclones over the Eurasian Arctic. Concomitantly, the Beaufort High tends to have weakened.
Parametric and Structural Sensitivities of Turbine‐Height Wind Speeds in the Boundary Layer Parameterizations in the Weather Research and Forecasting Model
Authors: Yang Ben , Berg Larry K. , Qian Yun , Wang Chen , Hou Zhangshuan , Liu Ying , Shin Hyeyum Hailey , Hong Songyou , Pekour Mikhail 
Published: April 2019

AbstractStructural and parametric problems associated with physical parameterizations are often tied together in weather and climate models. This study examines the sensitivities of turbine‐height wind speeds to structural and parametric uncertainties associated with the planetary boundary layer (PBL) parameterizations in the Weather Research and Forecasting model over an area of complex terrain. The sensitivity analysis is based on experiments from two perturbed parameter ensembles using the Mellor‐Yamada‐Nakanishi‐Niino (MYNN) and Yonsei University (YSU) PBL schemes, respectively. In each scheme, most of the intermember variances can be explained by a few parameters. Compared to the YSU parameters, the MYNN parameters induce relatively weaker (stronger) impacts on wind speeds during daytime (nighttime). The two schemes can overall reproduce the observed diurnal features of turbine‐height wind speeds. Differences in the daytime wind speeds are evident between the two ensembles. The daytime biases exist even with well‐tuned parameter values in MYNN, indicating the structural error. The YSU scheme better matches monthly mean daytime observations, partly due to the compensation among the biases in different wind strengths. Compared to YSU, MYNN generally better agrees with observations in both weak and strong wind conditions. However, the improvements accomplished for one condition by parameter tuning may degrade model performances for others, suggesting the relationships that link different conditions are not accurately represented in the parameterizations. Simulated biases due to structural errors are further identified by evaluating them for different time of day and locations. Ultimately, this study improves understanding of structural limitations in the PBL schemes and provides insights on further parameterization development.
Optical Properties and Radiative Forcing of Aged BC due to Hygroscopic Growth: Effects of the Aggregate Structure
Authors: Zeng Chen , Liu Chao , Li Jiangnan , Zhu Bin , Yin Yan , Wang Yuan 
Published: April 2019

AbstractBlack carbon (BC) particles become hydrophilic after mixing with soluble matter in the atmosphere, and their optical and radiative properties can be significantly modified accordingly. This study investigates the impact of aggregate structure on optical and radiative properties of aged BC, that is, BC coated by sulfate or organic aerosols, especially during hygroscopic growth. A more realistic BC morphology based on fractal aggregates is considered, and inhomogeneous mixtures of BC aggregates are treated more realistically (with respect to particle geometries) in the multiple sphere T‐matrix method for optical property simulations. As relative humidity increases, BC extinction is significantly enhanced due to an increase in scattering, and the enhancement depends on the amount and hydrophilicity of the coating. The absorption exhibits less variation during hygroscopic growth because the coating of aerosols already leads to BC absorption close to the maximum. Furthermore, hygroscopic growth not only results in negative radiative forcing (RF) at the top of the atmosphere but also slightly weakens the absorption in the atmosphere (inducing a negative RF in the atmosphere). Compared to the more realistic model with BC as aggregates, the currently popular core‐shell model reasonably approximates the top of the atmosphere RF but underestimates the atmospheric RF due to hygroscopic growth by up to 40%. Furthermore, for the RF caused by internal mixing, the core‐shell model overestimates the RFs at the surface and in the atmosphere by ~10%.
Quantifying Uncertainties of Ground‐Level Ozone Within WRF‐Chem Simulations in the Mid‐Atlantic Region of the United States as a Response to Variability
Authors: Thomas Andrew , Huff Amy K. , Hu Xiao‐Ming , Zhang Fuqing 
Published: April 2019

AbstractUnderstanding forecast uncertainties and error growth dynamics is a prerequisite for improving dynamical prediction of meteorology and air quality. While predictability of meteorology has been investigated over the past few decades, the uncertainties in air quality simulations are less well known. This study explores the uncertainties in predicting ground‐level ozone (O3) in the Mid‐Atlantic region of the United States during June 2016 through a series of simulations using WRF‐Chem, focusing on the sensitivity to the meteorological initial and boundary conditions (IC/BCs), emissions inventory (EI), and planetary boundary layer (PBL) scheme. The average uncertainty of ground‐level maximum 8‐hr average O3 mixing ratio (MD8‐O3) was most sensitive to uncertainties in the IC/BCs, while uncertainty in the EI was of secondary importance, and was least sensitive was to the use of different PBL schemes. Updating the NO emissions in the EI had the greatest influence on the accuracy, with an estimated decrease of 0.59 ppbv/year in the root‐mean‐square error and an average decrease of 0.63 ppbv/year in the values of modeled MD8‐O3. Our study suggests using perturbations in IC/BCs may lead to a more dispersive ensemble of O3 prediction than using different PBL schemes and/or different EI. However, considering the combined uncertainties from all three sources examined are still smaller than the averaged root‐mean‐square errors of predicted O3 against observations, there are apparent other sources of uncertainties not studied that need to be considered in future ensemble predictions of O3.
High‐Frequency Wave Generation in Magnetotail Reconnection: Linear Dispersion Analysis
Authors: Burch J.L. , Dokgo K. , Hwang K.J. , Torbert R.B. , Graham D.B. , Webster J.M. , Ergun R.E. , Giles B.L. , Allen R.C. , Chen L.‐J. , Wang S. , Genestreti K.J. , Russell C.T. , Strangeway R.J. , Le Contel O. 
Published: April 2019

AbstractPlasma and wave measurements from the NASA Magnetospheric Multiscale mission are presented for magnetotail reconnection events on 3 July and 11 July 2017. Linear dispersion analyses were performed using distribution functions comprising up to six drifting bi‐Maxwellian distributions. In both events electron crescent‐shaped distributions are shown to be responsible for upper hybrid waves near the X‐line. In an adjacent location within the 3 July event a monodirectional field‐aligned electron beam drove parallel‐propagating beam‐mode waves. In the 11 July event an electron distribution consisting of a drifting core and two crescents was shown to generate upper‐hybrid and beam‐mode waves at three different frequencies, explaining the observed broadband waves. Multiple harmonics of the upper hybrid waves were observed but cannot be explained by the linear dispersion analysis since they result from nonlinear beam interactions.
Dysregulation of kynurenine metabolism is related to proinflammatory cytokines, attention, and prefrontal cortex volume in schizophrenia
Authors: Kindler Jochen , Lim Chai K. , Weickert Cynthia Shannon , Boerrigter Danny , Galletly Cherrie , Liu Dennis , Jacobs Kelly R. , Balzan Ryan , Bruggemann Jason , O’Donnell Maryanne , Lenroot Rhoshel , Guillemin Gilles J. , Weickert Thomas W. 
Published: April 2019

AbstractThe kynurenine pathway (KP) of tryptophan (TRP) catabolism links immune system activation with neurotransmitter signaling. The KP metabolite kynurenic acid (KYNA) is increased in the brains of people with schizophrenia. We tested the extent to which: (1) brain KP enzyme mRNAs, (2) brain KP metabolites, and (3) plasma KP metabolites differed on the basis of elevated cytokines in schizophrenia vs. control groups and the extent to which plasma KP metabolites were associated with cognition and brain volume in patients displaying elevated peripheral cytokines. KP enzyme mRNAs and metabolites were assayed in two independent postmortem brain samples from a total of 71 patients with schizophrenia and 72 controls. Plasma KP metabolites, cognition, and brain volumes were measured in an independent cohort of 96 patients with schizophrenia and 81 healthy controls. Groups were stratified based on elevated vs. normal proinflammatory cytokine mRNA levels. In the prefrontal cortex (PFC), kynurenine (KYN)/TRP ratio, KYNA levels, and mRNA for enzymes, tryptophan dioxygenase (TDO) and kynurenine aminotransferases (KATI/II), were significantly increased in the high cytokine schizophrenia subgroup. KAT mRNAs significantly correlated with mRNA for glial fibrillary acidic protein in patients. In plasma, the high cytokine schizophrenia subgroup displayed an elevated KYN/TRP ratio, which correlated inversely with attention and dorsolateral prefrontal cortex (DLPFC) volume. This study provides further evidence for the role of inflammation in a subgroup of patients with schizophrenia and suggests a molecular mechanism through which inflammation could lead to schizophrenia. Proinflammatory cytokines may elicit conversion of TRP to KYN in the periphery and increase the N-methyl-d-aspartate receptor antagonist KYNA via increased KAT mRNA and possibly more enzyme synthesis activity in brain astrocytes, leading to DLPFC volume loss, and attention impairment in schizophrenia.
VPS33B interacts with NESG1 to modulate EGFR/PI3K/AKT/c-Myc/P53/miR-133a-3p signaling and induce 5-fluorouracil sensitivity in nasopharyngeal carcinoma
Authors: Liang Zixi , Liu Zhen , Cheng Chao , Wang Hao , Deng Xiaojie , Liu Jiahao , Liu Chen , Li Yonghao , Fang Weiyi 
Published: April 2019

AbstractThe vacuolar protein sorting 33B (VPS33B) was rarely reported in malignant tumors. In this research, we demonstrated that overexpression of VPS33B inhibited proliferation and chemoresistance to fluorouracil (5-FU) in nasopharyngeal carcinoma (NPC) in vivo and in vitro. Mechanistic analysis confirmed that overexpression of VPS33B modulated EGFR/PI3K/AKT/c-Myc/P53 signaling to arrest the cell cycle at G1/S phase. In addition, miR-133a-3p, a tumor-suppressive miRNA, was induced by P53 and directly targeted the EGFR/PI3K/AKT/c-Myc/P53 signaling and thus formed a negative feedback loop. Furthermore, another tumor suppressor, NESG1, interacted with VPS33B by colocalizing in the cytoplasm. The knockdown of NESG1 reversed the inhibitory effects of the overexpression of VPS33B in NPC cells by downregulating the PI3K/AKT/c-Jun-mediated transcription repression. Surprisingly, VPS33B was downregulated in the nicotine-treated and LMP-1-overexpressing NPC cells by targeting PI3K/AKT/c-Jun-mediated signaling. In addition, patients with higher VPS33B expression had a longer overall survival. Our study is the first to demonstrate that VPS33B is negatively regulated by LMP-1 and nicotine and thus suppresses the proliferation of NPC cells by interacting with NESG1 to regulate EGFR/PI3K/AKT/c-Myc/P53/miR-133a-3p signaling in NPC cells.
NKG2A is a NK cell exhaustion checkpoint for HCV persistence
Authors: Zhang Chao , Wang Xiao-mei , Li Shu-ran , Twelkmeyer Trix , Wang Wei-hong , Zhang Sheng-yuan , Wang Shu-feng , Chen Ji-zheng , Jin Xia , Wu Yu-zhang , Chen Xin-wen , Wang Sheng-dian , Niu Jun-qi , Chen Hai-rong , Tang Hong 
Published: April 2019

AbstractExhaustion of cytotoxic effector natural killer (NK) and CD8+ T cells have important functions in the establishment of persistent viral infections, but how exhaustion is induced during chronic hepatitis C virus (HCV) infection remains poorly defined. Here we show, using the humanized C/OTg mice permissive for persistent HCV infection, that NK and CD8+ T cells become sequentially exhausted shortly after their transient hepatic infiltration and activation in acute HCV infection. HCV infection upregulates Qa-1 expression in hepatocytes, which ligates NKG2A to induce NK cell exhaustion. Antibodies targeting NKG2A or Qa-1 prevents NK exhaustion and promotes NK-dependent HCV clearance. Moreover, reactivated NK cells provide sufficient IFN-γ that helps rejuvenate polyclonal HCV CD8+ T cell response and clearance of HCV. Our data thus show that NKG2A serves as a critical checkpoint for HCV-induced NK exhaustion, and that NKG2A blockade sequentially boosts interdependent NK and CD8+ T cell functions to prevent persistent HCV infection.