bluuebunny/crossref_metadata_2025_split huggingface dataset:
E-cadherin expression pattern during zebrafish embryonic epidermis development
Authors: Sampedro María Florencia , Izaguirre María Fernanda , Sigot Valeria 
Published: February 2019

Background: E-cadherin is the major adhesion receptor in epithelial adherens junctions (AJs). On established epidermis, E-cadherin performs fine-tuned cell-cell contact remodeling to maintain tissue integrity, which is characterized by modulation of cell shape, size and packing density. In zebrafish, the organization and distribution of E-cadherin in AJs during embryonic epidermis development remain scarcely described.Methods:Combining classical immunofluorescence, deconvolution microscopy and 3D-segmentation of AJs in epithelial cells, a quantitative approach was implemented to assess the spatial and temporal distribution of E-cadherin across zebrafish epidermis between 24 and 72 hpf.Results:increasing levels of E-cadh protein parallel higher cell density and the appearance of hexagonal cells in the enveloping layer (EVL) as well as the establishments of new cell-cell contacts in the epidermal basal layer (EBL), being significantly between 31 and 48 hpf.Conclusions:Increasing levels of E-cadherin in AJs correlates with extensive changes in cell morphology towards hexagonal packing during the epidermis morphogenesis.
Prenatal maternal stress and risk of neurodevelopmental disorders in the offspring: A systematic review and meta-analysis protocol
Authors: Manzari Nicla , Matvienko-Sikar Karen , Baldoni Franco , O'Keeffe Gerard W. , Khashan Ali 
Published: February 2019

Background: Prenatal maternal stress (PNMS) is defined as the experience of significant levels of prenatal stress, depression or anxiety during pregnancy. PNMS has been associated with increased risk of autism spectrum disorder (ASD) and attention-deficit hyperactivity disorder (ADHD) in exposed offspring. However, these findings are inconsistent and other studies found no association, meaning a clear consensus on the impact of PNMS on ASD and ADHD risk is required. The purpose of this systematic review and meta-analysis is to summarize and critically review the existing literature on the effects of PNMS on ASD and ADHD risk. Methods: Electronic databases (PubMed, PsycINFO, Web of Science, Scopus and EMBASE) will be searched for articles following a detailed search strategy. We will include cohort and case-control studies that assessed maternal exposure to psychological and/or environmental stress and had ASD or ADHD as an outcome. Two reviewers will independently screen the titles, abstracts and full articles to identify eligible studies. We will use a standardised data extraction form for extracting data and a bias classification tool for assessing study quality. This systematic review will be reported according to the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA). The generic inverse variance method will be used if possible to perform meta-analyses. Ethics and dissemination: Ethical approval is not required for this study because it will not involve the conduct or inclusion of any experimental or personal data that would require informed consent. The systematic review will be disseminated in peer-reviewed journals. PROSPERO registration number: CRD42018084222.
Thoracic Endovascular Aortic Repair for Aortoesophageal Fistula after Covered Rupture of Aortic Homograft
Authors: Nozdrzykowski Michal , Garbade Jens , Leinung Steffen , Schmidt Andrej , Mohr Friedrich-Wilhelm , Borger Michael 
Published: February 2019

AbstractA 63-year-old woman underwent replacement of the aortic root, ascending aorta, and partial arch due to Type A aortic dissection. Shortly thereafter, a replacement of the distal aortic arch and descending aorta was performed. Three years later, the patient developed an aortoesophageal fistula (AEF) resulting in re-replacement of the distal aortic arch and proximal descending aorta with a cryopreserved aortic homograft. Six weeks post-discharge, the patient was readmitted due to recurrent AEF. A thoracic endovascular stent graft was implanted to cover the aortic rupture, followed by correction of an esophageal lesion. The patient was monitored closely over time.
Nutrient Mass Balance and Fate in Dairy Cattle Lots with Different Surface Materials
Authors: Vadas Peter A. , Powell J. Mark 
Published: February 2019

Abstract.On dairy farms, outdoor lots where cows spend substantial time can be areas of high nutrient deposition in manure. This represents an inefficient use of farm nutrients, if the nutrients are not recovered, and a potential for nutrient loss to the environment. Management of barnyards to recover nutrients can have environmental and production benefits. We monitored nitrogen (N) and phosphorus (P) fate for five years in dairy heifer barnyard plots constructed with soil, sand, or bark mulch surfaces. The plots were stocked with heifers several times per year for about a week at a time. We monitored N and P loss in runoff (soil plots only), leachate, and gas emissions. Of the total N inputs to the plots through heifer excretion, 6% to 8% of inputs were lost in runoff (~2%), leachate (~3% to 4%), and gas emissions (~3% to 4%) from the soil and mulch plots. Most of the N inputs remained in the surface materials. For the sand plots, more N inputs were lost in leachate (~13%) and gas emissions (~6%), but most of the N remained in the surface material. Of total P inputs to the plots through heifer excretion, 4% to 6% of inputs were lost in runoff and leachate, with most of the P remaining in the surface materials. The results suggest that most of the nutrients deposited by heifers onto barnyards could be recovered and used as fertilizer for crop growth by excavating the surface materials and spreading them on cropland, by including animal holding areas in land used for crop rotation so crops can recover nutrients , or by corralling animals directly on cropland. Keywords: Barnyards, Cattle, Leaching, Nutrients, Runoff.
El espectáculo fronterizo de la “victimización” del migrante
Authors: Genova Nicholas de 
Published: February 2019

Resumen
No hay nada evidente por sí mismo respecto de la migración «ilegal». Cuando las fronteras se convierten en el espectáculo de la muerte de los migrantes, los discursos de su «victimización» a mano de los «contrabandistas» nos distraen de las verdaderas causas de la ilegalización de los migrantes. Este breve ensayo descubre y visibiliza el espectáculo fronterizo que vigila, controla y determina la aceptación o rechazo de los migrantes. Esta situación – dentro del marco de secutirización de las fronteras – deja vulnerables a los migrantes, haciéndolos pasibles de ser explotados en la sociedad receptora. Esa situación contribuye también a la contribuye a la racialización de los migrantes.

Palabras clave: Espectáculo fronterizo, victimización de migrantes, securitización, control de fronteras, migraciones.
Extranjeros bajo la lupa: La figura del «falso turista» en Argentina
Authors: Baiadera Angélica Alvites 
Published: February 2019

Resumen
El artículo analiza la categoría estatal denominada «Falso Turista» (FT) en Argentina. Para esto, desde una metodología cualitativa, se realiza un análisis documental que permite reconstruir las condiciones de emergencia y desarrollo sobre cómo el Estado define, clasifica e interviene en sus políticas de ingreso y rechazo en frontera en particular a partir del FT. La principal conclusión del artículo radica en comprender que la aplicación del FT no tiene por objetivo el cierre total de la frontera o el rechazo de todos los sujetos que se mueven sino una gestión diferencial de las circulaciones, una vigilancia orientada y selectiva para separar los sujetos «deseables» de los «indeseables», en base a su potencial comportamiento futuro en destino.

Palabras clave: Migraciones internacionales, Políticas de frontera, Falso turista, Argentina
EVALUASI PROGRAM PEMANENAN AIR HUJAN (RAIN WATER HARVESTING) BADAN LINGKUNGAN HIDUP KOTA SEMARANG
Authors: Abadi Debby Rinata , Kismartini Kismartini , Sundarso Sundarso 
Published: February 2019

The formulation of climate change impacts in Semarang produced five major issues: flooding, tidal flood, landslides, drought and outbreaks of infectious diseases. Rain Water Harvesting Program implemented by Regulation of the Minister of Environment No. 12 in 2009 was an attempt by Semarang government for adaptation to climate change. This evaluation aims to determine the results of the implementation and the factors that affect the implementation of the program. The results can be seen through the implementation of an evaluation process based on the Model Evaluation System Analysis in inputs, processes and outputs Based on Suitability Model by David C. Korten factors that support and hinder namely compatibility between programs with beneficiaries, the fit between programs by implementing organizations and the fit between user groups with the implementing organization. Based on the existing obstacles in the implementation of the Program Harvesting Rain Water Environment Agency of Semarang, the authors give a recommendation either: (1) changes in socialization patterns, (2) not only focus on physical development but the socialization benefits of using rainwater, (3) improving access to information for community, (4) make scientific criteria for target groups, (5) integrated with IMB licensing requirements.
Evolutionary quasi-variational and variational inequalities with constraints on the derivatives
Authors: Miranda Fernando , Rodrigues José Francisco , Santos Lisa 
Published: February 2019

Abstract
This paper considers a general framework for the study of the existence of
quasi-variational and variational solutions to a class of nonlinear evolution
systems in convex sets of Banach spaces describing constraints on a
linear combination of partial derivatives of the solutions. The quasi-linear operators are
of monotone type, but are not required to be coercive for the existence of weak solutions, which
is obtained by a double penalization/regularization for the approximation of the solutions. In
the case of time-dependent convex sets that are independent of the solution, we show
also the uniqueness and the continuous dependence of the strong solutions of the variational
inequalities, extending previous results to a more general framework.
Evaluating the diagnostic and prognostic value of serum long non-coding RNA CTC-497E21.4 in gastric cancer
Authors: Zong Wei , Feng Wei , Jiang Yun , Ju Shaoqing , Cui Ming , Jing Rongrong 
Published: February 2019

Abstract

Background
Long non-coding RNAs (lncRNAs) have been reported to play a key role in gastric cancer (GC) tumorigenesis. However, the clinical application value of serum lncRNAs in GC has remained largely unknown. We investigated the role of a novel lncRNA named CTC-497E21.4 in the diagnosis and the prognosis of GC.

Methods
We focused on evaluation of lncRNA CTC-497E21.4 by real-time fluorescent quantitative polymerase chain reaction (RTFQ-PCR). The study involved following aspects: (1) confirmation of the higher lncRNA CTC-497E21.4 expression in different types of GC specimens than corresponding controls; (2) evaluation of monitoring tumor dynamics by the serum lncRNA CTC-497E21.4 assay; (3) evaluation of the prognostic value of lncRNA CTC-497E21.4 assay in GC.

Results
(1) The method of RTFQ-PCR detection of lncRNA CTC-497E21.4 was evaluated to have high sensitivity and specificity. (2) The expression levels of lncRNA CTC-497E21.4 were higher in GC patients compared with corresponding controls (p<0.001), and the combination of serum lncRNA CTC-497E21.4, CEA and CA19-9 could improve diagnostic sensitivity (96.36%). (3) The serum lncRNA CTC-497E21.4 expression levels were lower in postoperative samples than preoperative samples (p=0.0021) and survival curves downloaded from TCGA showed high lncRNA CTC-497E21.4 levels were associated with poor OS of GC (p=0.0351).

Conclusions
lncRNA CTC-497E21.4 may be a potential biomarker for the diagnosis and the prognosis of GC.
Improving Wastewater Nitrogen Removal and Reducing Effluent NOx - -N by an Oxygen-Limited Process Consisting of a Sequencing Batch Reactor and a Sequencing Batch Biofilm Reactor
Authors: Hajsardar Mehdi , Borghei Seyed Mehdi , Hassani Amir Hessam , Takdastan Afshin 
Published: February 2019

Abstract
A series of reactors including a sequencing batch reactor (SBR) and a sequencing batch biofilm reactor (SBBR) were used for nitrogen removal. The aim of this study was simultaneous removal of NH4+-N and NOx–-N from synthetic wastewater. In the novel proposed method, the effluent from SBR was sequentially introduced into SBBR, which contained 0.030 m3 biofilm carriers, so the system operated under a paired sequence of aerobic-anoxic conditions. The effects of different carbon sources and aeration conditions were investigated. A low dissolved oxygen (DO) level in the biofilm depth of the fixed-bed process (SBBR) simulated the anoxic phase conditions. Accordingly, a portion of NH4+-N that was not converted to NO3–-N by the SBR process was converted to NO3–-N in the outer layer of the biofilm in the SBBR process. Further, simultaneous nitrification and denitrification (SND) was achieved in the SBBR where NO2–-N was converted to N2 directly, before NO3–-N conversion (partial nitrification). The level of mixed liquid suspended solids (MLSS) was 2740 mg/l at the start of the experiments. The required carbon source (C: N ratio of 4) was provided by adding an internal carbon source (through step feeding) or ethanol. Firstly, as part of the system (SBR and SBBR), SBR operated at a DO level of 1 mg/l while SBBR operated at a DO concentration of 0.3 mg/l during Run-1. During Run-2, the system operated at the low DO concentration of 0.3 mg/l. When the source of carbon was ethanol, the nitrogen removal rate (RN) was higher than the operation with an internal carbon source. When the reactors were operated at the same DO concentration of 0.3 mg/l, 99.1 % of the ammonium was removed. The NO3–-N produced during the aerobic SBR operation of the novel method was removed in SBBR reactor by 8.3 %. The concentrations of NO3--N and NO2–-N in the SBBR effluent were reduced to 2.5 and 5.5 mg/l, respectively. Also, the total nitrogen (TN) removal efficiency was 97.5 % by adding ethanol at the DO level of 0.3 mg/l.
When C:N adjustment was carried out SND efficiency at C:N ratio of 6.5 reached to 99 %. The increasing nitrogen loading rate (NLR) to 0.554 kg N/m3 d decreased SND efficiency to 80.7 %.
Analysis of Four Wave Mixing In Ultra Dense WDM-Hybrid Optical Amplifier Systems
Authors: Singh Navjot , Kumar Mahendra , Verma Ashu 
Published: February 2019

Abstract
Amplification through hybrid optical amplifiers (HOAs) is a propitious and proficient technology for high speed and high capacity dense wavelength-division-multiplexing (DWDM) systems. HOAs are intended to improve system reach and to accomplish wide gain bandwidth with enhanced flatness of gain. In this work, an ultradense 16 channel WDM system is demonstrated and performance of diverse hybrid amplifiers is evaluated in terms of output power, Q-factor, gain flatness and BER. Spacing among the WDM channels is 25 GHz in order to make system bandwidth efficient and scrutinized its effect on four wave mixing (FWM) in case of EDFA-EDFA, Raman-EDFA and SOA-EDFA. It is observed that SOA-EDFA is more and Raman-EDFA is less prone to FWM. Moreover, for distance 20 Km–140 Km, Raman-EDFA is optimal configuration for amplification and from 150 Km–200  Km, SOA-EDFA shows better performance. For prolonged link lengths such as beyond 200  Km, EDFA-EDFA is a right hybrid amplifier. In order to achieve maximum gain flatness in proposed architecture, EDFA-EDFA is recommended to use.
Una revisión sobre el concepto de competencia educativa
Authors: Patiño Ruth Alejandra 
Published: February 2019

El documento aborda los diferentes aspectos relacionados con el concepto de “competencia”, el cual, es el eje articulador alrededor del cual se estructuran los diferentes programas de formación en educación superior, y particularmente en Contaduría Pública. La reflexión pone de presente la dificultad para la comprensión del término, y la inconsistencia de su uso en el diseño de los diferentes currículos en Contaduría. Concluye que es fundamental ampliar el debate sobre el concepto, en un entorno más amplio que el relacionado a las capacidades y desempeños laborales de los futuros contadores.
Eficacia de la quimioterapia de inducción en el tratamiento del cáncer de cabeza y cuello en el Hospital San Juan de Dios, del año 2010 al 2013.
Authors: Fernández Barrantes Cristina , Ugalde Rojas Irene , Forester Quesada Mario , Cordero García Eugenia , Ramos Esquivel Allan 
Published: February 2019

Objetivos: evaluar la efectividad de la quimioterapia de inducción en el tratamiento del cáncer de cabeza y cuello en el Hospital San Juan de Dios, del 2010 al 2013. Métodos: Los expedientes clínicos de los pacientes diagnosticados con cáncer de cabeza y cuello y tratados del año 2010 al 2014, fueron analizados de manera retrospectiva. Se analizó información demográfica, clínica y de tratamiento. Las tasas de supervivencia y sobrevida libre de progresión fueron calculadas por medio de gráficos de Kaplan-Meier. La mediana de seguimiento para los 33 pacientes fue de 20 meses. Del total de los pacientes incluidos en el estudio, 7 pacientes (21%) fueron tratados con quimioterapia de inducción mientras que 26 pacientes (79%) recibieron quimioradioterapia como tratamiento definitivo. Conclusión: La respuesta a los 6 meses refleja una respuesta completa del 79% en ambos grupos, sin embargo, no existe una diferencia estadísticamente significativa en la supervivencia de los pacientes con tratamiento de inducción respecto a aquellos que no recibieron este tratamiento.
Patrones de uso racional de medicamentos en una muestra representativa del estudiantado y profesorado de la Universidad de Costa Rica en el año 2017.
Authors: Arias Zapata Andrés , Coto Arce Karla Vanessa , Villalobos Herrera Daniela , Ortiz Ureña Angie 
Published: February 2019

Objetivo: analizar los patrones de consumo de medicamentos de los profesores y estudiantes de la Universidad de Costa Rica en la sede Rodrigo Facio durante el año 2017, mediante la utilización de un instrumento digital enviado a una muestra representativa de la población vía correo electrónico o por redes sociales. Resultados: Se halló que la mayoría de los encuestados obtienen sus medicamentos por cuenta propia en farmacias de comunidad, refieren casi nunca automedicarse y casi siempre seguir indicaciones; almacenan los medicamentos mayoritariamente en el dormitorio, en una gaveta o caja; no suelen revisar con frecuencia las fechas de vencimiento y desechan los productos en el basurero común; desconocen las campañas de recolección que se realizan en el país, pero estarían dispuestos a asistir a charlas sobre uso racional de medicamentos. Conclusiones: El perfil del consumidor promedio analizado muestra que existen serias deficiencias en cuanto a algunos aspectos de la obtención, uso, almacenamiento y desecho de medicamentos, las cuales podrían solventarse con una mejor divulgación no solo de campañas de recolección de estos productos, sino también con estrategias educativas sobre uso racional, tanto en la Universidad de Costa Rica como en las farmacias de comunidad.
Variabilidad de Baylisascariasis como diagnóstico diferencial de <i>larva migrans</i> en humanos, Costa Rica.
Authors: Baldi Salas Mario , Walzer Chris 
Published: February 2019

Baylisascariasis es una enfermedad causada por una larva migras muy agresiva en humanos y animales, clasificada como una zoonosis emergente de importancia en salud pública. El agente causal es el nemátodo Baylisascaris procyonis, siendo su huésped definitivo el mapache común (Procyon lotor). Reportes de la presencia de este parásito en poblaciones de mapaches en la zona urbana de Costa Rica, alerta sobre la necesidad de conocer su ciclo de vida, diagnóstico, transmisión y prevención de este parásito. Esta revisión contempla los aspectos más relevantes del nemátodo en relación con la salud pública, así como su ciclo de vida, diagnóstico, tratamiento y prevención. Concientizando con ello, a los trabajadores de la salud pública y animal sobre la necesidad de considerar al Baylisascaris procyonis dentro de sus diagnósticos diferenciales de larvas migrantes causados por otros nemátodos del orden Ascaridida en Costa Rica y posiblemente en la región Mesoamericana y el Caribe.
Recurrent Pneumonitis in Patients with Melanoma Treated with Immune Checkpoint Inhibitors
Authors: Asher Nethanel , Marom Edith M. , Ben-Betzalel Guy , Baruch Erez Nissim , Steinberg-Silman Yael , Schachter Jacob , Shapira-Frommer Ronnie , Markel Gal 
Published: February 2019

Abstract

Introduction
Immune checkpoint inhibitors (ICIs) have changed the oncologic landscape in the past few years. Alongside impressive antitumor responses, new novel immune-related adverse events (irAEs) have emerged; pneumonitis is an irAE that can potentially be fatal and necessitates a proper management. No consensus exists regarding steroid treatment duration or drug rechallenge options. Our study describes the clinical and radiological course of melanoma patients diagnosed with immune-related pneumonitis that has recurred because of rechallenge attempt or despite complete treatment discontinuation (unprovoked).

Materials and Methods
The study population was composed of patients with metastatic melanoma who were treated with anti-programmed cell death 1 (PD-1) as monotherapy or in combination with anti-cytotoxic T lymphocyte antigen-4 and who were diagnosed with immune-related pneumonitis. For recurrent cases after clinical and radiological resolution, we explored the differences from cases with no recurrence.

Results
Nineteen out of 386 (4.8%) patients treated with ICI were diagnosed with pneumonitis. Median age was 66 years, and 53% were male. Compared with single-agent nivolumab, patients treated with ipilimumab-nivolumab combination presented with an earlier onset (27.5 vs. 10.3 weeks, respectively, p = .015) and had higher grades of severity. After complete resolution, rechallenge was attempted in seven patients; three of them had recurrent pneumonitis. Three other patients experienced recurrent pneumonitis despite complete discontinuation of the drug (unprovoked by rechallenge). The latter were characterized with an earlier onset of the first pneumonitis compared with those who did not experience recurrence (median, 12.4 vs. 26.4 weeks) and a shorter course of steroid treatment at first episode (median, 5.1 vs. 10 weeks). Recurrent cases were generally more severe than the first episode.

Conclusion
Unprovoked recurrent pneumonitis is a new, poorly reported entity that requires further investigation. Our observations suggest that cases of pneumonitis that present early in the course of immunotherapy treatment may recur despite treatment discontinuation, thus necessitating closer monitoring and a longer course of steroid treatment.
Análise paratradutiva das diferentes edicións do Manifesto do Partido Comunista ao galego: a ideoloxía das marxes
Authors: Baxter Robert Neal 
Published: February 2019

Este artigo presenta o concepto de ‘paratexto’ e a súa utilidade práctica aplicada á análise tradutolóxica, concretamente sob o modelo de ‘paratradución’ acuñado e desenvolvido na Universidade de Vigo. Este marco teórico serve como ferramenta para analizar as oito versións do Manifesto do Partido Comunista publicadas en galego para tentar dilucidar cales poden ser as súas pretendidas funcións latentes, para alén da simple función comunicativa interlingüística. O artigo conclúe incidindo na importancia que teñen os paratextos para entender un texto traducido na súa globalidade, ao recalcar que, se ben se trata dunha mesma obra orixinal de partida, existen elementos que condicionan a recepción de cada tradución que as torna textos diferentes.