bluuebunny/crossref_metadata_2025_split huggingface dataset:
HB-EGF Synthesized by CD4 T Cells Modulates Allergic Airway Eosinophilia by Regulating IL-5 Synthesis
Authors: Farahnak Soroor , Simon Leora , McGovern Toby K. , Chen Michael , Khazaei Niusha , Martin James G. 
Published: May 2019

Abstract
CD4 T cells express the epidermal growth factor (EGF) receptor ligand, heparin-binding EGF (HB-EGF), with no defined immuno-pathophysiological function. Therefore, we wished to elucidate the function of HB-EGF synthesized by CD4 T cells in the context of allergic pulmonary inflammation and the asthma surrogate, airway hyperresponsiveness, in a murine acute model of asthma. In this study, we show how knocking out HB-EGF expression in CD4 T cells in vivo attenuates IL-5 synthesis in the lung that is accompanied by diminished eosinophilic inflammation and airway hyperresponsiveness. HB-EGF coimmunoprecipitates with the transcriptional repressor B cell lymphoma 6 (Bcl-6) in CD4 T cells. Knocking out HB-EGF in CD4 T cells resulted in increased Bcl-6 binding to the IL-5 gene and decreased IL-5 mRNA expression. Thus, these findings suggest an immunoregulatory function for intrinsic HB-EGF expressed by CD4 T cells in TH2 inflammation and airway dysfunction by modulating IL-5 expression via binding to and inhibiting the repressive function of Bcl-6.
Undergraduate nursing students’ perceptions of integrating evidence into practice in a psychiatric-mental health nursing clinical course
Authors: Charania Nadia Ali Muhammad Ali , Ross-Durow Paula Lynn , Sullivan Barbara-Jean , Dansel Laura A. 
Published: May 2019

Faculty in a baccalaureate nursing program recognized the need to make intentional efforts to assist nursing students in integrating evidence-based knowledge in their clinical learning. This paper aims to describe ways in which evidence-based practice (EBP) was incorporated into Psychiatric-Mental Health Clinical Course (P-MHCC) assignments, and summarize students’ perceptions about their use of evidence in their clinical practice. Content analysis was performed on 64 student essays. Four themes were identified following analyses of students’ written self-reflections: clinical assignments created opportunities to incorporate EBP, assignments promoted exploration of resources and fostered development of a professional self-concept, use of evidence in mental health nursing, and students’ views on future use of EBP and barriers. Clinical assignments and educational experiences were influential in students’ utilization of EBP. Students agreed on the value of EBP in their development as nurses and as being necessary to provide the best care to patients. Three future recommendations were proposed. First, faculty facilitating clinical courses must integrate EBP as a consistent component across all clinical assignments and employ specific rubrics to help students recognize the importance of evidence in clinical practice. Second, faculty must be proactive to explore and address students’ barriers to integration of EBP in a P-MHCC. Finally, clinical faculty should consider the use of EBP in clinical assignments as one of the strategies to promote students’ professional self-concept. Future research should include systematically exploring and testing the teaching strategies used by nursing faculty at all levels of the baccalaureate program to determine their effectiveness in improving baccalaureate-nursing students’ knowledge and skills.
Análisis de las actuaciones de protección ambiental y gestión turística en el Parque Regional de Calblanque, Monte de las Cenizas y Peña del Águila (Murcia, SE España)
Authors: Belmonte Serrato Francisco , Ballesteros Pelegrín Gustavo A. , Sánchez Sánchez Miguel Ángel 
Published: May 2019

El Parque Regional de Calblanque, Monte de las Cenizas y Peña del Águila tiene 2.822 ha y más de 13 Km de costa en los municipios de Cartagena y la Unión. Con el objetivo de evaluar la gestión, conservación ambiental y turística entre 2000-2017, se utiliza como metodología el análisis de las memorias e informes de la administración. El resultado es la participación de 7 profesionales, un presupuesto anual superior a 600 mil euros para mantenimiento y limpieza, vigilancia, información y atención al visitante, infraestructuras y equipamientos de uso público, conservación de unas salinas, del bosque de Tetraclinis articulata y limitación de accesos de vehículos en verano.
The Regional Park of Calblanque, Monte de las Cenizas and Peña del Águila has 2,822 hectares and more than 13 km of coastline in the municipalities of Cartagena and La Union. With the objective of evaluating the management, environmental and tourist conservation between 2000-2017, the analysis of the reports and reports of the administration is used as a methodology. The result is the participation of 7 professionals, an annual budget of over 600 thousand euros for maintenance and cleaning, surveillance, information and visitor assistance, infrastructures and equipment for public use, conservation of some salt mines, the Tetraclinis articulata forest and limitation of vehicle accesses in summer.
Actividad turística en Cartagena (Murcia) a través del análisis de indicadores y percepción de sus actores directos
Authors: Jiménez Meseguer María José , Morales Yago Francisco José 
Published: May 2019

La Recuperación del patrimonio cultural, natural y paisajístico de la ciudad de Cartagena constituyen un elemento clave en el desarrollo local de esta ciudad, así como un cambio en el modelo de desarrollo económico tradicionalmente dedicado principalmente al sector industrial, militar y portuario. En la actualidad la preponderancia del turismo como actividad dinamizadora está generando la creación de muchos puestos de trabajo tanto en la atención directa a los visitantes como a la necesidad de recuperar y mostrar un patrimonio cultural en muchos casos oculto desde hace siglos. El presente trabajo ofrece desde el uso estadístico de indicadores básicos y el propio análisis de encuesta, datos clarificadores sobre la actividad turística actual en Cartagena.
The recovery of the cultural, natural and landscape heritage of the city of Cartagena is a key element in the local development of this city, as well as a change in the model of economic development traditionally dedicated mainly to the industrial, military and port sectors. At present, the preponderance of tourism as a dynamic activity is generating the creation of many jobs both in the direct attention to visitors and the need to recover and show a cultural heritage in many cases hidden for centuries. The present work offers, from the statistical use of basic indicators and the own analysis of the survey, clarifying data about the current tourist activity in Cartagena.
Tres santuarios y tres modelos de gestión turística en la montaña sagrada de Randa (Mallorca)
Authors: Novo Malvárez Margarita , Forteza Oliver Miquela 
Published: May 2019

El objetivo principal de esta investigación es estudiar los diferentes modelos de gestión turística de los tres santuarios localizados en la montaña de Randa (Mallorca), territorio en el que tienen cabida diversas espiritualidades y donde se distinguen diferentes fórmulas de entretenimiento y mercantilización de lo sagrado. La variedad de opciones que se materializan, indican una realidad dinámica y cambiante, extrapolable a otros lugares del ámbito internacional.
The objective of this research is to study the different models of tourism management of the three sanctuaries located in the mountain of Randa (Mallorca), territory where different spiritualities can be found and where different formulas of entertainment and commercialization of the sacred are distinguished. The variety of materialized options indicate a dynamic and changing reality, extrapolated to other places in the international context.
Nonrigid registration of medical image based on adaptive local structure tensor and normalized mutual information
Authors: Yang Tiejun , Tang Qi , Li Lei , Song Jikun , Zhu Chunhua , Tang Lu 
Published: May 2019

AbstractNonrigid registration of medical images is especially critical in clinical treatment. Mutual information is a popular similarity measure for medical image registration; however, only the intensity statistical characteristics of the global consistency of image are considered in MI, and the spatial information is ignored. In this paper, a novel intensity‐based similarity measure combining normalized mutual information with spatial information for nonrigid medical image registration is proposed. The different parameters of Gaussian filtering are defined according to the regional variance, the adaptive Gaussian filtering is introduced into the local structure tensor. Then, the obtained adaptive local structure tensor is used to extract the spatial information and define the weighting function. Finally, normalized mutual information is distributed to each pixel, and the discrete normalized mutual information is multiplied with a weighting term to obtain a new measure. The novel measure fully considers the spatial information of the image neighborhood, gives the location of the strong spatial information a larger weight, and the registration of the strong gradient regions has a priority over the small gradient regions. The simulated brain image with single‐modality and multimodality are used for registration validation experiments. The results show that the new similarity measure improves the registration accuracy and robustness compared with the classical registration algorithm, reduces the risk of falling into local extremes during the registration process.
Nonflammable and Magnetic Sponge Decorated with Polydimethylsiloxane Brush for Multitasking and Highly Efficient Oil–Water Separation
Authors: Liu Yingying , Wang Xin , Feng Shengyu 
Published: May 2019

AbstractDeveloping sponge materials integrating excellent flame retardancy, multitasking separation performance, and efficient emulsion‐breaking ability is significant but challenging for the remediation of oil spills causing fires and environmental damages. Herein, a superhydrophobic oil–water separation sponge material, containing a melamine‐formaldehyde (MF) sponge substrate, magnetic polydopamine (PDA) coating, and branched polydimethylsiloxane (PDMS) brush, through dopamine‐mediated surface initiated atom transfer radical polymerization (SI‐ATRP) is fabricated. The synergistic flame resistance of the MF substrate and PDMS brush significantly improves its adaptability in fire. More importantly, the decorated PDMS brushes can effectively overcome the size mismatch between sponge macropores and tiny emulsified droplets, while remaining the intrinsic macroporous characteristic. When treating W/O emulsions, the PDMS brushes stretch up to act as “interface‐breaking blades” to accelerate the coalescence of emulsified water droplets. Meanwhile, such PDMS brushes can serve as “oil‐trapping tentacles” to efficiently capture oil droplets when treating O/W emulsions. Such material design synergistically contributes to satisfactory separation efficiency (98.7%) and ultrahigh permeation flux (up to 1.35 × 105 L m−2 h−1), even for treating high viscosity emulsions. Besides, the reported sponge also inherits robust durability, superior recyclability, and convenient magnetic collection. These features make the sponge promising for multitasking and highly efficient oil–water separation.
Adiponitrile (C6H8N2): A New Bi‐Functional Additive for High‐Performance Li‐Metal Batteries
Authors: Lee Seon Hwa , Hwang Jang‐Yeon , Park Seong‐Jin , Park Geon‐Tae , Sun Yang‐Kook 
Published: May 2019

AbstractRechargeable batteries with a Li metal anode and Ni‐rich Li[NixCoyMn1−x−y]O2 cathode (Li/Ni‐rich NCM battery) have been emerging as promising energy storage devices because of their high‐energy density. However, Li/Ni‐rich NCM batteries have been plagued by the issue of the thermodynamic instability of the Li metal anode and aggressive surface chemistry of the Ni‐rich cathode against electrolyte solution. In this study, a bi‐functional additive, adiponitrile (C6H8N2), is proposed which can effectively stabilize both the Li metal anode and Ni‐rich NCM cathode interfaces. In the Li/Ni‐rich NCM battery, the addition of 1 wt% adiponitrile in 0.8 m LiTFSI + 0.2 M LiDFOB + 0.05 M LiPF6 dissolved in EMC/FEC = 3:1 electrolyte helps to produce a conductive and robust Li anode/electrolyte interface, while strong coordination between Ni4+ on the delithiated Ni‐rich cathode and nitrile group in adiponitrile reduces parasitic reactions between the electrolyte and Ni‐rich cathode surface. Therefore, upon using 1 wt% adiponitrile, the Li/full concentration gradient Li[Ni0.73Co0.10Mn0.15Al0.02]O2 battery achieves an unprecedented cycle retention of 75% over 830 cycles under high‐capacity loading of 1.8 mAh cm−2 and fast charge–discharge time of 2 h. This work marks an important step in the development of high‐performance Li/Ni‐rich NCM batteries with efficient electrolyte additives.
Photoresponsive Actuators Built from Carbon‐Based Soft Materials
Authors: Yang Meijia , Yuan Zhongke , Liu Jie , Fang Zhengsong , Fang Long , Yu Dingshan , Li Quan 
Published: May 2019

AbstractPhotoresponsive soft actuators with photomechanical energy conversion and flexibility have attracted significant interest in recent years owing to their unique merits of flexibility, contactless operation, and remote control, as well as their multiple technological applications ranging from bionic robotics and biomedical devices to nanomotors. Seeking efficient photoresponsive materials with high energy conversion efficiency and robust mechanical properties and identifying effective photoactuation mechanisms are of paramount significance for the development of advanced photoactuators. Due to their unique optical properties, high mechanical strength, superior electrical and thermal conductivity, good flexibility, and stability, carbon‐based materials are regarded as attractive candidates for high‐performance photoresponsive actuators. Furthermore, easy functionalization or hybridization with other functional species substantially extends the functions of these materials and widens the application scope for photoactuators. Herein, this review summarizes the recent progress of photoactuators based on various carbon‐based soft materials, including 0D, 1D, 2D, and 3D nanocarbons as well as their functional soft composites with other responsive materials. Multiple driving schemes of photoresponsive actuators including photothermal, photomechanical, photoelectronic, and photochemical effects, photoactuating architecture design, and potential technological applications of photoactuators are elucidated. Furthermore, certain future opportunities and challenges in the ever‐flourishing optical‐to‐mechanical energy conversion area are emphasized and discussed.
Photomobile Polymer Materials with Complex 3D Deformation, Continuous Motions, Self‐Regulation, and Enhanced Processability
Authors: Ube Toru , Ikeda Tomiki 
Published: May 2019

AbstractLiquid‐crystalline polymers with photodeformable properties have been extensively studied due to their ability of wireless conversion of light energy into mechanical work. With the development of crosslinked liquid‐crystalline polymers, various 3D motions, such as bending, twisting, oscillation, rotation, and translational motion have been successfully induced. Recent trends for developing soft robots and microrobots accelerate the progress of photomobile polymer materials. This review is focused on recent advances in the field of photomobile materials based on liquid‐crystalline polymers. The structure–function relationship in photomobile polymer materials is overviewed, and the progress in recent years is detailed in terms of complex 3D deformation, continuous motions, self‐regulation, and processability.
Quantum Well Energetics of an n = 2 Ruddlesden–Popper Phase Perovskite
Authors: Silver Scott , Dai Qingqing , Li Hong , Brédas Jean‐Luc , Kahn Antoine 
Published: May 2019

AbstractA comprehensive investigation of the electronic energy levels of an n = 2 Ruddlesden–Popper phase perovskite is presented. Ultraviolet and inverse photoemission spectroscopies are used to probe the density of states in the valence and conduction bands, respectively, of the quasi‐2D perovskite, butylammonium cesium lead iodide (BA2CsPb2I7). By comparing experimental spectra with calculated projected density of states, the contributions from Cs, Pb, and I to the quantum well states are identified, and distinguished from those of the organic ligand barrier layer. The ionization energy, electron affinity, and exciton binding energy of this material are derived. The energetics of the quantum well structure are discussed in terms of the number of Pb‐halide layers. The resulting energy diagram suggests that a type‐I heterojunction would be formed with the n = 1 BA2PbI4. Finally, surface photovoltage performed via Kelvin probe force microscopy is used to evaluate band bending at the surface of the BA2CsPb2I7 thin films.
Variation in facial bone growth remodeling in prehistoric populations from southern South America
Authors: Brachetta‐Aporta Natalia , Gonzalez Paula N. , Bernal Valeria 
Published: May 2019

AbstractObjectivesTo assess the intraspecific variation in bone remodeling patterns in modern humans, we studied two populations from southern South America that represent the extremes of morphological variation in this region. We particularly analyzed the ontogenetic changes in the patterns of bone growth remodeling and compared the patterns between samples.Materials and methodsWe obtained high‐resolution casts of the periosteal surface of the upper and middle face of subadults (n = 36) and adult (n = 36) individuals from a sample of hunter‐gatherers from Patagonia and a sample of horticulturists from Northwest Argentina. The areas of bone formation and resorption were registered using an incident‐light microscope. We then estimated the average bone remodeling map by sample and age, and performed principal component analysis and multivariate regressions to assess the extension and distribution of these areas across ontogeny and between samples.ResultsWe found that the remodeling pattern of the glabella, supraorbital arch, frontal process of the maxilla, and a large part of the zygomatic bone is relatively constant in subadults and adults from both sample with a clear predominance of bone formation. In contrast, the middle face is characterized by the spatial alternation between formation and resorption areas, and greater variation with age and between samples. The main differences were found in areas related to chewing and muscle insertions.ConclusionsOur study provides the first evidence of interpopulation variation in bone growth remodeling and suggests that biomechanical factors can influence the observed patterns. It also underlines the need to account for ecological factors in within and between species comparisons.
Productive Manipulation of Cyanine Dye π‐Networks
Authors: Usama Syed Muhammad , Thompson Tye , Burgess Kevin 
Published: May 2019

AbstractPolymethine bridges in cyanine dyes may be constrained by setting them into edge‐fused ring systems, or extended by conjugation with carefully chosen heterocycles. Recent studies have shown that modifications like these can give significantly brighter dyes with red‐shifted absorbance and emission maxima.
Using metro lines for integration of nucleotide metabolic pathways
Authors: Lee Rebecca K. Y. , Ng Bernard Y. N. , Chen Daisy M. H. 
Published: May 2019

AbstractStudents always encounter difficulties in studying biochemical pathways. They are especially weak in understanding the relationships between metabolic pathways and their integration because these pathways are always taught one‐by‐one in class. In the past, various online resources have been developed to facilitate students' understanding toward energy metabolism. Although these learning materials enable students to understand individual metabolic pathway in a clearer manner, many of them fail to demonstrate the linkages between these pathways. The “AG City” is a self‐learning tool which aims to arouse students' interest in exploring nucleotide metabolism. We have designed a metro map as a concept map to allow students to have an overview of different pathways as well as their integration. Major pathways are presented as railway lines in an easy‐to‐understand and interactive manner using navigation, animations, and narrations. Key molecules involved in the pathways are presented as “railway stations”. Students can easily identify common “railway stations” presented in different pathways and link the concepts that they have learnt together. This interactive self‐learning tool has been packaged as a courseware using the Articulate Storyline eLearning authoring software. © 2019 International Union of Biochemistry and Molecular Biology, 47(5):532–537, 2019.
Suitability of a generic virus safety evaluation for monoclonal antibody investigational new drug applications
Authors: Sipple Patrick , Nguyen Tung , Patel Krina , Jaffe Neil , Chen Yan , Khetan Anurag 
Published: May 2019

AbstractBiologics produced from CHO cell lines with endogenous virus DNA can produce retrovirus‐like particles in cell culture at high titers, and other adventitious viruses can find their way through raw materials into the process to make a product. Therefore, it is the industry standard to have controls to avoid introduction of viruses into the production process, to test for the presence of viral particles in unclarified cell culture, and to develop purification procedures to ensure that manufacturing processes are robust for viral clearance. Data have been accumulated over the past four decades on unit operations that can inactivate and clear adventitious virus and provide a high degree of assurance for patient safety. During clinical development, biological products are traditionally tested at process set points for viral clearance. However, the widespread implementation of platform production processes to produce highly similar IgG antibodies for many indications makes it possible to leverage historical data and knowledge from representative molecules to allow for better understanding and control of virus safety. More recently, individualized viral clearance studies are becoming the rate‐limiting step in getting new antibody molecules to clinic, particularly in Phase 0 and eIND situations. Here, we explore considerations for application of a generic platform virus clearance strategy that can be applied for relevant investigational antibodies within defined operational parameters in order to increase speed to the clinic and reduce validation costs while providing a better understanding and assurance of process virus safety.