bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Impact of Advance Care Planning on End-of-Life Care: Do the Type and Timing Make a Difference for Patients With Advanced Cancer Referred to Hospice?
Authors: Prater Laura C. , Wickizer Thomas , Bower Julie K. , Bose-Brill Seuli 
Published: May 2019

Purpose: This study aimed to determine the impact of advanced care planning (ACP) on potentially avoidable hospital admissions at the end of life (EOL) among a sample of hospice-referred patients with cancer, in order to present actionable considerations for the practicing clinician. Methods: This study was designed as a retrospective cohort using electronic health record data that assessed likelihood of hospital admissions in the last 30 days of life for 1185 patients with a primary diagnosis of cancer, referred to hospice between January 1, 2014, and December 31, 2015, at a large academic medical center. Inverse probability treatment weighting based on calculated propensity scores balanced measured covariates between those with and without ACP at baseline. Odds ratios (ORs) were calculated from estimated potential outcome means for the impact of ACP on admissions in the last 30 days of life. Results: A verified do-not-resuscitate (DNR) order prior to the last 30 days of life was associated with reduced odds of admission compared to those without a DNR (OR = 0.30; P < .001). An ACP note in the problem list prior to the last 30 days of life was associated with reduced odds of admission compared to those without an ACP note (OR = 0.71, P = .042), and further reduced odds if done 6 months prior to death (OR = 0.35, P < .001). Conclusions: This study shows that dedicated ACP documentation is associated with fewer admissions in the last 30 days of life for patients with advanced cancer referred to hospice. Improving ACP processes prior to hospice referral holds promise for reducing EOL admissions.
Evaluation of Total Ankle Arthroplasty Using Highly Crosslinked Ultrahigh-Molecular-Weight Polyethylene Subjected to Physiological Loading
Authors: Bischoff Jeffrey E. , Dharia Mehul A. , Hertzler Justin S. , Schipper Oliver N. 
Published: May 2019

Background: Highly crosslinked polyethylene (HXLPE) was developed for its superior wear properties in comparison to conventional polyethylene (CPE). Concern over fatigue resistance has prevented widespread adoption of HXLPE for use in total ankle arthroplasty (TAA). The aim of this study was to determine whether HXLPE has sufficient fatigue strength for total ankle arthroplasty under simulated physiologically relevant motion profiles and loading in the ankle. Methods: Physiologic load and motion profiles representative of walking gait were incorporated into a computational model of a semiconstrained, fixed-bearing TAA to determine the loading state with highest stresses in the HXLPE bearing. Subsequent fatigue testing to 10 million cycles (Mc) at 5600 N was performed to assess bearing strength. Results: Peak stresses in the bearing were predicted at peak axial load and peak dorsiflexion during gait, occurring near heel off. All samples withstood 10 Mc of fatigue loading at that orientation without polyethylene bearing fracture. Conclusion: HXLPE had sufficient fatigue strength to withstand 10 Mc of loading at more than 5 times body weight at the point of peak stresses during simulated gait in total ankle arthroplasty. Clinical Relevance: HXLPE may be mechanically strong enough to withstand the in vivo demands of the ankle. Improvements in wear afforded by HXLPE can be obtained without compromising sufficient polyethylene strength properties in total ankle arthroplasty.
Conjunctival tattoo with inadvertent ocular globe penetration and vitreous involvement: Clinico-pathological correlation and scanning electron microscopy X-ray microanalysis
Authors: Rodríguez-Avila J Oswaldo , Ríos y Valles-Valles Dolores , Hernández-Ayuso Ivette , Rodríguez-Reyes Abelardo A , Morales Cantón Virgilio , Cernichiaro-Espinosa Linda A 
Published: May 2019

Purpose: The aim is to report a case of conjunctival tattooing with inadvertent injection of tattoo ink into the vitreous cavity and its consequences, the scanning electron microscopy X-ray microanalysis of the ink components, and the microscopic findings of the affected conjunctiva and vitreous. Methods: Descriptive case report. Results: A 32-year-old man complained of ocular pain and blurred vision after undergoing a subconjuctival red ink tattoo in his left eye. Ophthalmologic examination revealed best corrected visual acuity of 20/80 and intraocular pressure of 26 mmHg. Pain was elicited with eye movements. The bulbar conjunctiva was colored intense red. In the anterior chamber, pigment granules and filaments were suspended on the aqueous humor, and lens capsule was also stained red. Ultrasonography showed high-density non-mobile echoes in the conjunctiva; anterior chamber and vitreous cavity revealed high-density mobile echoes corresponding to pigment particles. Conjunctival tattoo with inadvertent globe penetration was the clinical diagnosis. The patient received medical and surgical treatment. Histopathological examination of the conjunctiva showed red pigment globular deposits within the stroma, and neutrophils and sparse histiocytes with similar intracytoplasmic pigment granules were seen. No granulomatous foreign body reaction was noticed. Vitreous material contained pigment granules; no inflammatory cells were observed. Scanning electron microscopy X-ray microanalysis of the tattoo red ink revealed significant signals of iron, barium, and copper. Conclusion: Conjunctival tattoo is a new form of body decoration gaining worldwide popularity. This procedure is performed by untrained professionals causing severe ocular complications including blindness. Safety regarding tattoo ink needs further study as the composition varies among colors. Strict regulations on this matter should be considered.
No Major Differences in Recovery After Hip Fracture Between Home-Dwelling Female and Male Patients
Authors: Lahtinen A. , Leppilahti J. , Vähänikkilä H. , Kujala S. , Ristiniemi J. , Jalovaara P. 
Published: May 2019

Background: Studies comparing recovery of men and women after hip fracture have reported conflicting results, some reporting worse recovery in male patients, while others found no differences between genders. Methods: Recovery was compared in 105 male and 433 female patients with hip fractures and in age-matched groups of patients 50 years or older, who were home-dwelling and received similar rehabilitation. Residential status, walking ability, hip pain and activities of daily living function were recorded at admission and 4 and 12 months postoperatively, along with mortality and re-operations. Results: No differences were observed between men and women 4 and 12 months postoperatively regarding residential status (p = 0.181 vs p = 0.883), mortality rates (p = 0.232 vs p = 0.880) or total activities of daily living scores (p = 0.546 vs p = 0.435). Walking ability was better among male patients prefracture (p < 0.001) and 4 and 12 months after fracture (p < 0.001, p = 0.031, respectively). In age-matched pair analysis, no differences were found regarding mortality, residential status, walking ability, or ADL score. Cox regression analysis identified mortality risk factors as being age, prefracture ADL score, American Society of Anesthesiologists score 4–5 and place of rehabilitation. Sex was not mortality risk factor. Interpretation: Home-dwelling male and female patients had similar courses of recovery from hip fracture, although there were singular differences in specific activities of daily living functions and postoperative pain. There were no differences in mortality, even when prefracture characteristics were considered. Mortality was higher among older patients and who had high American Society of Anesthesiologists scores and low prefracture activities of daily living scores.
Colon Cancer Cell Secretes EGF to Promote M2 Polarization of TAM Through EGFR/PI3K/AKT/mTOR Pathway
Authors: Lian Guanghui , Chen Shuijiao , Ouyang Miao , Li Fujun , Chen Linlin , Yang Junwen 
Published: May 2019

Background: Tumor environment has been recognized to affect cancer cell progression, such as tumor-associated macrophages. However, increasing evidences suggest that tumor cells are capable of regulating polarization of tumor-associated macrophages. In this study, we investigate the mechanism of how colon cancer cell impacts tumor-associated macrophages polarization. Methods: We employed flow cytometry to detect marker molecules on macrophage membrane, such as CD68, CD16, and CD204. In addition, we used enzyme-linked immunosorbent assay to examine the level of these cytokines (interleukin-6, interleukin-1β, interleukin-10, and Arginase-1) secreted by colon cancer cells into the culture medium. Western blot was utilized to probe downstream proteins of epidermal growth factor receptor (EGFR)/phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT)/mammalian target of rapamycin (mTOR) pathway. Results: We cocultured colon cancer cell lines (HCT8 or HCT116) with human myeloid leukemia mononuclear cells (THP-1) and found that interleukin-6 and interleukin-1β levels were reduced, and instead, interleukin-10 and Arginase-1 levels were elevated, suggesting that colon cancer cells contributed to M2 polarization of THP-1. Meanwhile, high level of various growth factors (transforming growth factor-β [TGF-β], epidermal growth factor [EGF], and hepatocyte growth factor [HGF]) was observed in the medium of THP-1 cocultured with colon cancer cells. Furthermore, the protein level of phosphorylated PI3K, AKT, and mTOR significantly increased in THP-1 cell cocultured with colon cancer cells compared to THP-1 group. Besides, we established that colon cancer cells exerted their stimulatory effect on M2 polarization of macrophage from monocyte THP-1 using EGFR antibody mAb225 and PI3K inhibitor LY294002. Conclusion: We provide evidence that EGF which are secreted by colon cancer cells play contributory role in M2 polarization of macrophages, which support the notion that tumor environment, including tumor-associated macrophages, can be targeted to develop effective strategies for treating cancer.
Clinical outcomes of patients receiving prolonged extracorporeal membrane oxygenation for respiratory support
Authors: Na Soo Jin , Jung Jae-Seung , Hong Sang-Bum , Cho Woo Hyun , Lee Sang-Min , Cho Young-Jae , Park Sunghoon , Koo So-My , Park Seung Yong , Chang Youjin , Kang Byung Ju , Kim Jung-Hyun , Oh Jin Young , Park So Hee , Yoo Jung-Wan , Sim Yun Su , Jeon Kyeongman 
Published: May 2019

Background: There are limited data regarding prolonged extracorporeal membrane oxygenation (ECMO) support, despite increase in ECMO use and duration in patients with respiratory failure. The objective of this study was to investigate the outcomes of severe acute respiratory failure patients supported with prolonged ECMO for more than 28 days. Methods: Between January 2012 and December 2015, all consecutive adult patients with severe acute respiratory failure who underwent ECMO for respiratory support at 16 tertiary or university-affiliated hospitals in South Korea were enrolled retrospectively. The patients were divided into two groups: short-term group defined as ECMO for ⩽28 days and long-term group defined as ECMO for more than 28 days. In-hospital and 6-month mortalities were compared between the two groups. Results: A total of 487 patients received ECMO support for acute respiratory failure during the study period, and the median support duration was 8 days (4–20 days). Of these patients, 411 (84.4%) received ECMO support for ⩽28 days (short-term group), and 76 (15.6%) received support for more than 28 days (long-term group). The proportion of acute exacerbation of interstitial lung disease as a cause of respiratory failure was higher in the long-term group than in the short-term group (22.4% versus 7.5%, p < 0.001), and the duration of mechanical ventilation before ECMO was longer (4 days versus 1 day, p < 0.001). The hospital mortality rate (60.8% versus 69.7%, p = 0.141) and the 6-month mortality rate (66.2% versus 74.0%, p = 0.196) were not different between the two groups. ECMO support longer than 28 days was not associated with hospital mortality in univariable and multivariable analyses. Conclusions: Short- and long-term survival rates among patients receiving ECMO support for more than 28 days for severe acute respiratory failure were not worse than those among patients receiving ECMO for 28 days or less.
The impact of moral philosophy and moral intensity on purchase behavior toward sustainable textile and apparel products
Authors: Hong Heesook , Kang Ji Hye 
Published: May 2019

AbstractThis study investigated the causal–effect relationships among moral philosophy, moral intensity, and purchase behavior toward environmentally sustainable textile and apparel products. A research model incorporating two dimensions of moral philosophy (i.e., idealism and relativism), five dimensions of moral intensity (i.e., magnitude, probability, temporal immediacy, proximity, and social consensus), and purchase behavior toward sustainable textile and apparel products was tested using consumer data collected from a wide age range of Korean females through online surveys. Organic and naturally dyed textile and apparel products were selected as focal interests of this study due to the significance of the two product markets in Korea. The results revealed that, of the two dimensions of moral philosophy, only idealism had a significant impact on overall moral intensity and moral intensity had a significant impact on consumer purchase behavior toward sustainable textile and apparel products, which confirmed the sequential relationship among the variables. As the first attempt, to our knowledge, to apply an ethical view to environmentally sustainable textile and apparel product consumption, this research contributes to a deeper understanding of the determinants of sustainable textile and apparel consumption among Korean consumers and the development of effective marketing communication strategies targeting Korean consumers.
Η επίδραση του οικογενειακού περιβάλλοντος στην εκπαιδευτική προσαρμογή νηπίων ινδικής καταγωγής
Authors: Kontogianni Dionisia 
Published: May 2019

The present study focuses on families of Indian immigrants. The subjects in question come from the state of Panjab and have a Sikh religion. Purpose of the study is to show the linguistic and sociocultural conditions that the Indian preschoolers experience in their family life in Greece. As long as the family is the basic area of the children’ socialization, the culture that the children experience in their family environment specifies the linguistic and cultural background when they start attending the Greek preschool. The data of the case-study in question were gathered through the interviews given by eleven parents of the preschoolers and three kindergarten teachers. What the data analysis has shown is a tendency of linguistic and sociocultural separation of the families from the dominant language and culture. This separation has a direct impact on the children’ adaptation at school. The tendency that the analysis has shown is related to the desire of the family to preserve the ethnocultural and religious identity of their country and is increased due to the restricted role of the woman inside the family and the community. It is also supported by the social role that the temple built by the Indian community at Rethymno plays.
Case Report: Investigation and molecular genetic diagnosis of familial hypomagnesaemia: a case report
Authors: Willows Jamie , Al Badi Maryam , Richardson Chloe , Edwards Noel , Rice Sarah , Sayer John A. 
Published: May 2019

Genetic mutations causing familial hypomagnesaemia syndromes are well-recognised. Affected patients can present with severe symptoms of hypomagnesaemia, such as seizures or cardiac arrhythmia. We report an affected child, from a consanguineous family, who presented in the first weeks of life with seizures secondary to hypomagnesaemia, without other associated clinical features. We performed whole exome sequencing in the affected child and segregation analysis within the family, which revealed a novel homozygous missense mutation in TRPM6, which was confirmed as a heterozygous allele in both parents and two younger siblings who had transient hypomagnesaemia. Using in silico modelling, we provide evidence that the missense variant p.(K1098E) in TRPM6 is pathogenic, as it disrupts stabilising TRP domain interactions. Management of familial hypomagnesaemia relies on prompt recognition, early magnesium replacement and lifelong monitoring.
Social support and sense of life in patients with anxiety disorders – preliminary report
Authors: Kroplewski Zdzisław , Serocka Alicja , Szcześniak Małgorzata 
Published: May 2019

Cel pracyWeryfikacja poziomu postrzegania odczuwanego wsparcia społecznego oraz poczucia sensu życia wśród osób z zaburzeniami lękowymi i osób zdrowych; ocena zależności między wymienionymi zmiennymi.MetodaZastosowano Kwestionariusz Wsparcia Społecznego w wersji skróconej (F-SozU K-22) G. Sommera i T. Fydricha oraz Kwestionariusz Postaw Życiowych (LAP-R) G. T. Rekera.WynikiWsparcie społeczne i jego wymiary okazują się znacząco niższe w grupie pacjentów z zaburzeniami lękowymi. Osoby zdrowe charakteryzują się wyższym poczuciem poczucia celu oraz kontroli nad życiem, większą spójnością wewnętrzną, osobowym sensem i równowagą postaw życiowych, przy mniejszym nasileniu doświadczania pustki egzystencjalnej. Wyższy poziom wsparcia emocjonalnego i starszy wiek wiążą się z wyższym poziomem poczucia sensu życia u osób cierpiących na zaburzenia lękowe.WnioskiW celach prewencyjnych i terapeutycznych, istotne jest podtrzymywanie, a także rozwijanie wewnętrznych zasobów jednostki (poczucie sensu życia i doświadczenie wynikające z wieku). Wydaje się również zasadnym stosowanie wśród pacjentów z zaburzeniami nerwicowymi psychoterapii nakierowanej na zmianę tych schematów funkcjonowania osobowości, które uniemożliwiają im budowanie sieci wsparcia społecznego. Wynika to z faktu, że zaburzenia lękowe często charakteryzują się niższą ufnością, unikaniem relacji interpersonalnych, zafałszowaną percepcją wsparcia społecznego, co prowadzi do zniekształconej interpretacji działań wspierających.
Intermediary role of mood in the way music affects emotional reception of visual stimuli in adolescents
Authors: Chęć Magdalena , Ligocka Maria , Janik Inga , Samochowiec Jerzy , Samochowiec Agnieszka 
Published: May 2019

Cel pracyMuzyka w życiu każdego, zwłaszcza młodego człowieka, odgrywa bardzo ważną rolę w odbiorze emocjonalnym rzeczywistości.
Celem pracy było określenie znaczenia pośredniczącej roli nastroju we wpływie muzyki na odbiór emocjonalny materiału obrazowego wśród adolescentów.MetodaW badaniu eksperymentalnym uczestniczyło 388 adolescentów (13 - 15 lat). Wykorzystano pozawerbalne narzędzie do badania emocji i uwagi (The International Affective Picture System), Kartę Nastroju i Kwestionariusz dla Młodzieży. Ponadto w eksperymencie zaprezentowano utwory reprezentujące tzw. środek trzech gatunków muzycznych (hip-hop, pop i metal).WynikiWyniki wskazały, że aktualny nastrój nastolatka wyznaczał odbiór emocjonalny zdjęć. Dobry nastrój wiązał się z obniżeniem pobudzenia emocjonalnego podczas odbioru neutralnych zdjęć (po wysłuchaniu muzyki metalowej i pop) oraz wywoływał większą przyjemność z oglądania pozytywnych i neutralnych zdjęć. Oglądanie negatywnych zdjęć przy średnim i dobrym nastroju wywoływało mniejszą przyjemność niż oglądanie ich w złym nastroju. Muzyka hip-hop i zły nastrój łączyły się z większym pobudzeniem emocjonalnym przy neutralnych zdjęciach. Żaden z wyników nie wykazał zależności pomiędzy słuchaniem przez młodzież (przy gorszym nastroju) muzyki z gatunku metal czy hip-hop a pozytywnym postrzeganiem obrazów.WnioskiPrzeprowadzone badania były próbą określenia związku pomiędzy trudnymi do uchwycenia czynnikami: nastrojem, muzyką i odbiorem emocjonalnym obrazów przez młodzież w okresie adolescencji. Mimo trudności metodologicznych zależność ta została ustalona.
Predictive role of retrospective assessment of parental attitudes of fathers vs. perfectionism and self-esteem of women in early adulthood
Authors: Walęcka-Matyja Katarzyna 
Published: May 2019

Cel pracyCelem badań było określenie zróżnicowania w zakresie samooceny i perfekcjonizmu w grupach kobiet wyróżnionych w oparciu o kryterium jakości retrospektywnej oceny postaw rodzicielskich ojców. Poszukiwano także wartości predykcyjnej retrospektywnie ujętych postaw rodzicielskich ojców dla perfekcjonizmu i samooceny kobiet w okresie wczesnej dorosłości oraz związków samooceny z rodzajami perfekcjonizmu.MetodaW badaniach uczestniczyło 87 kobiet w okresie wczesnej dorosłości (M=21,64, SD=4,84), pochodzących z województwa łódzkiego. Zastosowano następujące narzędzia badawcze: Kwestionariusz Retrospektywnej Oceny Postaw Rodziców, Kwestionariusz Perfekcjonizmu Adaptacyjnego i Dezadaptacyjnego, Wielowymiarowy Kwestionariusz Samooceny.WynikiUzyskane rezultaty badań wskazują na występowanie zróżnicowania w zakresie samooceny i perfekcjonizmu kobiet w zależności od retrospektywnej oceny postaw rodzicielskich ojców. Kobiety negatywnie oceniające postawy rodzicielskie ojców uzyskały wyższe wyniki średnie w zakresie perfekcjonizmu dezadaptacyjnego oraz niższe w zakresie samooceny ogólnej i jej wymiarów (tj. bycie kochanym, samokontrola, obronne wzmacnianie samooceny, samoakceptacja, popularność, integracja tożsamości) niż kobiety określające postawy rodzicielskie ojców jako pozytywne. Stwierdzono, że retrospektywna ocena postaw rodzicielskich ojców, rozpatrywana zarówno w aspekcie pozytywnym jak i negatywnym miała wartość predykcyjną, w kierunku zgodnym z oczekiwaniami dla perfekcjonizmu dezadaptacyjnego oraz samooceny ogólnej i jej wymiarów. Wykazano występowanie istotnych związków między rodzajami perfekcjonizmu oraz samooceną ogólną.WnioskiWskazanie na rolę retrospektywnej oceny postaw rodzicielskich ojców w kształtowaniu samooceny i perfekcjonizmu młodych kobiet przyczynia się zarówno do zaktualizowania wiedzy psychologicznej z tego zakresu, jak i ma istotne znaczenie w psychoterapii.
General health, sense of coherence and coping styles in parents participating in Workshops for Parents of Hyperactive Children
Authors: Pisula Agnieszka , Bryńska Anita , Wójtowicz Stanisław , Srebnicki Tomasz , Wolańczyk Tomasz 
Published: May 2019

Cel pracyocena zmian w zakresie ogólnego stanu zdrowia, poczucia koherencji oraz stylów radzenia sobie ze stresem rodziców dzieci i młodzieży z ADHD, uczestniczących w 12-tygodniowych ‘Warsztatach dla rodziców dzieci nadpobudliwych’.Metodagrupę eksperymentalną stanowiło n=186 matek i n=139 ojców (rodzice n=199 dzieci), a grupę odniesienia n=23 matki i n=19 ojców (rodzice n=24 dzieci), uczestniczących w okresie 12-tygodni w 1-2 standardowych wizytach lekarskich (teratment as usual). Rodzice z obu grup zostali poddani dwukrotnemu badaniu z zastosowaniem (1) kwestionariusza Ogólnego Stanu Zdrowia GHQ, (2) kwestionariusza Orientacji Życiowej SOC-29 oraz (3) kwestionariusza radzenia sobie w sytuacjach stresowych CISS.Wyniki(1) w grupie eksperymentalnej wykazano istotną poprawę w zakresie nasilenia objawów somatycznych i niepokoju/bezsenności u matek oraz ogólnego samopoczucia matek oraz ojców, wpływ na poczucie zaradności matek oraz redukuję poziomu emocjonalnego stylu radzenia sobie ze stresem matek; (2) uczestnictwo w warsztatach w ocenie matek wiązało się z istotnym statystycznie efektem (najczęściej umiarkowany) w odniesieniu do ich ogólnego stanu zdrowia, zaś oddziaływania typu as usual wiązały się w większości z efektem małym lub nieznaczącym.WnioskiOceniana forma oddziaływań wpływa na poprawę funkcjonowania rodziców dzieci z ADHD.