bluuebunny/crossref_metadata_2025_split huggingface dataset:
An effective computational approach based on Gegenbauer wavelets for solving the time-fractional Kdv-Burgers-Kuramoto equation
Authors: Secer Aydin , Ozdemir Neslihan 
Published: September 2019

Abstract
In this paper, our purpose is to present a wavelet Galerkin method for solving the time-fractional KdV-Burgers-Kuramoto (KBK) equation, which describes nonlinear physical phenomena and involves instability, dissipation, and dispersion parameters. The presented computational method in this paper is based on Gegenbauer wavelets. Gegenbauer wavelets have useful properties. Gegenbauer wavelets and the operational matrix of integration, together with the Galerkin method, were used to transform the time-fractional KBK equation into the corresponding nonlinear system of algebraic equations, which can be solved numerically with Newton’s method. Our aim is to show that the Gegenbauer wavelets-based method is efficient and powerful tool for solving the KBK equation with time-fractional derivative. In order to compare the obtained numerical results of the wavelet Galerkin method with exact solutions, two test problems were chosen. The obtained results prove the performance and efficiency of the presented method.
Treatment-Free Survival: A Novel Outcome Measure of the Effects of Immune Checkpoint Inhibition—A Pooled Analysis of Patients With Advanced Melanoma
Authors: Regan Meredith M. , Werner Lillian , Rao Sumati , Gupte-Singh Komal , Hodi F. Stephen , Kirkwood John M. , Kluger Harriet M. , Larkin James , Postow Michael A. , Ritchings Corey , Sznol Mario , Tarhini Ahmad A. , Wolchok Jedd D. , Atkins Michael B. , McDermott David F. 
Published: September 2019

PURPOSE Outcome measures that comprehensively capture attributes of immuno-oncology agents, including prolonged treatment-free time and persistent treatment-related adverse events (TRAEs), are needed to complement conventional survival end points. METHODS We pooled data from the CheckMate 067 and 069 clinical trials of nivolumab and ipilimumab, as monotherapies or in combination, for patients with advanced melanoma. Treatment-free survival (TFS) was defined as the area between Kaplan-Meier curves for two conventional time-to-event end points, each defined from random assignment: time to immune checkpoint inhibitor (ICI) protocol therapy cessation and time to subsequent systemic therapy initiation or death. TFS was partitioned as time with and without toxicity by a third end point, time to cessation of both ICI therapy and toxicity. Toxicity included persistent and late-onset grade 3 or higher TRAEs. The area under each Kaplan-Meier curve was estimated by the 36-month restricted mean time. RESULTS At 36 months, many of the 1,077 patients who initiated ICI therapy were surviving free of subsequent therapy initiation (47% nivolumab plus ipilimumab, 37% nivolumab, 15% ipilimumab). The restricted mean TFS was longer for nivolumab plus ipilimumab (11.1 months) compared with nivolumab (4.6 months; difference, 6.5 months; 95% CI, 5.0 to 8.0 months) or ipilimumab (8.7 months; difference, 2.4 months; 95% CI, 0.8 to 4.1 months); restricted mean TFS represented 31% (3% with and 28% without toxicity), 13% (1% and 11%), and 24% (less than 1% and 23%) of the 36-month period, respectively, in the three treatment groups. TFS without toxicity was longer for nivolumab plus ipilimumab than nivolumab (difference, 6.0 months) or ipilimumab (difference, 1.7 months). CONCLUSION The analysis of TFS between ICI cessation and subsequent therapy initiation revealed longer TFS without toxicity for patients with advanced melanoma who received nivolumab plus ipilimumab compared with nivolumab or ipilimumab. Regardless of treatment, a small proportion of the TFS involved grade 3 or higher TRAEs.
Morphology-dependent random binary fragmentation of in silico fractal-like agglomerates
Authors: Drossinos Y. , Melas A. D. , Kostoglou M. , Isella L. 
Published: September 2019

Abstract
Linear binary fragmentation of synthetic fractal-like agglomerates composed of spherical, equal-size, touching monomers is numerically investigated. Agglomerates of different morphologies are fragmented via random bond removal. The fragmentation algorithm relies on mapping each agglomerate onto an adjacency matrix. The numerically determined fragment size distributions are U-shaped, clusters break predominantly into two largely dissimilar fragments, becoming more uniform as the fractal dimension decreases. A symmetric beta distribution reproduces the fragment distribution rather accurately. Its exponent depends on the structure (fractal dimension) and number of monomers of the initial agglomerate. A universal fragment distribution, a function only of the initial fractal dimension, is derived by requiring that it satisfy the fragmentation conversation laws and the straight-chain limit. We argue that the fragmentation rate is proportional to the initial agglomerate size.
Pathogenic FAM83G palmoplantar keratoderma mutations inhibit the PAWS1:CK1α association and attenuate Wnt signalling.
Authors: Wu Kevin Z.L. , Jones Rebecca A. , Tachie-Menson Theresa , Macartney Thomas J. , Wood Nicola T. , Varghese Joby , Gourlay Robert , Soares Renata F. , Smith James C. , Sapkota Gopal P. 
Published: September 2019

Background: Two recessive mutations in the FAM83G gene, causing A34E and R52P amino acid substitutions in the DUF1669 domain of the PAWS1 protein, are associated with palmoplantar keratoderma (PPK) in humans and dogs respectively. We have previously reported that PAWS1 associates with the Ser/Thr protein kinase CK1α through the DUF1669 domain to mediate canonical Wnt signalling. Methods: Co-immunoprecipitation was used to investigate possible changes to PAWS1 interactors caused by the mutations. We also compared the stability of wild-type and mutant PAWS1 in cycloheximide-treated cells. Effects on Wnt signalling were determined using the TOPflash luciferase reporter assay in U2OS cells expressing PAWS1 mutant proteins. The ability of PAWS1 to induce axis duplication in Xenopus embryos was also tested. Finally, we knocked-in the A34E mutation at the native gene locus and measured Wnt-induced AXIN2 gene expression by RT-qPCR. Results: We show that these PAWS1A34E and PAWS1R52P mutants fail to interact with CK1α but, like the wild-type protein, do interact with CD2AP and SMAD1. Like cells carrying a PAWS1F296A mutation, which also abolishes CK1α binding, cells carrying the A34E and R52P mutants respond poorly to Wnt signalling to an extent resembling that observed in FAM83G gene knockout cells. Consistent with this observation, these mutants, in contrast to the wild-type protein, fail to induce axis duplication in Xenopus embryos. We also found that the A34E and R52P mutant proteins are less abundant than the native protein and appear to be less stable, both when overexpressed in FAM83G-knockout cells and when knocked-in at the native FAM83G locus. Ala34 of PAWS1 is conserved in all FAM83 proteins and mutating the equivalent residue in FAM83H (A31E) also abolishes interaction with CK1 isoforms. Conclusions: We propose that mutations in PAWS1 cause PPK pathogenesis through disruption of the CK1α interaction and attenuation of Wnt signalling.
Kapasitas Kelembagaan Dalam Pembinaan Usaha Mikro Kecil Dan Menengah Di Kota Surakarta
Authors: Sukoco Johan Bhimo 
Published: September 2019

Micro-, Small-, and Medium-Scale Enterprises (SMEs) building is often due to the weak institutional capacity. Limited capital ownership, poor business knowledge, and narrow business network make SME performers less powerful in improving their business. This research studied the SMEs building in Surakarta City, viewed from indicator of empowerment according to Mardikanto (2013), Institutional Building. This research employed a descriptive qualitative method. Data collection was carried out using interview, observation, and document analysis. Technique of analyzing data used was purposive sampling, data validation was carried out using method triangulation, and data analysis was conducted using an interactive model of analysis. The result of research showed that institutional capacity of SMEs in Surakarta City was still weak. SMEs performers (actors) still understood poorly the procedure and requirement of business licensing. This made them dealing with business licensing reluctantly, leading to the weak business institution. Pembinaan Usaha Mikro Kecil dan Menengah (UMKM) seringkali dikarenakan lemahnya kapasitas kelembagaan. Kepemilikan modal yang minim, pengetahuan usaha yang rendah, serta kurang luasnya jejaring usaha membuat pelaku UMKM menjadi kurang berdaya dalam meningkatkan usahanya. Penelitian ini mengkaji pembinaan UMKM di Kota Surakarta dilihat dari indikator pemberdayaan menurut Mardikanto (2010), yaitu Bina Kelembagaan. Penelitian ini menggunakan metode deskriptif kualitatif. Pengumpulan data menggunakan wawancara, observasi, dan analisis dokumen. Teknik pengumpulan data menggunakan purposive sampling, validitas data menggunakan triangulasi metode, dan analisis data menggunakan analisis interaktif. Hasil penelitian menunjukkan kapasitas kelembagaan UMKM di Kota Surakarta masih lemah. Pelaku UMKM masih kurang memahami prosedur dan persyaratan perizinan usaha. Hal ini mengakibatkan pelaku UMKM enggan melakukan pengurusan perizinan usaha yang berakibat lemahnya kelembagaan usaha.
Multikriteria Analisis dalam Pemilihan Alat Pengumpul Sampah dengan Pembobotan Kombinasi Hasil Analysis Hierarchy Process (AHP) dan Time Motion Study (TMS)
Authors: Chaerul Mochammad , Rahmania Syiffa 
Published: September 2019

Pengumpulan sampah merupakan salahsatu tahapan dalam suatu sistem pengelolaan sampah suatu kota. Efektifitas dan efisiensi pengumpulan sampah dipengaruhi oleh jenis alat yang digunakan. Pemilihan alat pengumpul sampah dipengaruhi oleh berbagai macam kriteria. Salahsatu metode multikriteria analisis yang paling sering digunakan adalah Analysis Hierarchy Process (AHP). Multikriteria tersebut bukan saja terbatas pada aspek teknis dan non-teknis semata tetapi juga aspek operasional masing-masing alat yang dapat didekati dengan metode Time Motion Study (TMS). Di banyak kasus, kedua metode multikriteria tersebut digunakan secara terpisah dan berdiri sendiri. Paper ini mencoba menggabungkan kedua metode tersebut untuk memilih 3 (tiga) alternatif alat pengumpul sampah, yaitu: gerobak, becak motor, dan truk yang digunakan di Kota Payakumbuh, Sumatera Barat sebagai studi kasus. Untuk aplikasi metode AHP, dipilih kelompok responden masyarakat, petugas pengumpul sampah, pemerintah dan akademisi dengan mempertimbangkan kriteria teknis, sosial, ekonomi, dan lingkungan. Penilaian rerata global dari seluruh kelompok responden menempatkan gerobak sebagai alat terbaik dengan nilai 0,381, dibandingkan becak motor (0,356) dan truk (0,263). Sedangkan dengan metode TMS, yang mempertimbangkan keseluruhan tahapan operasional masing-masing alat pengumpul sampah didapat nilai kecepatan dan efisiensi pengumpulan sampah tertinggi adalah untuk becak motor, yaitu masing-masing sebesar 56,32 m/menit dan 49,53 kg/menit, dibandingkan untuk truk dan gerobak. Penggabungan metode AHP dan TMS dilakukan dengan cara memberikan bobot untuk masing-masing parameter dari hasil kedua metode tersebut yang telah dinormalisasi. Urutan prioritas alat pengumpul yang terbaik bisa saja berbeda ketika bobot masing-masing parameter tersebut dirubah. Penggabungan kedua metode tersebut menghasilkan pilihan yang lebih baik dan dapat dijadikan sebagai pertimbangan bagi pengambil keputusan sehingga dapat diperoleh alat pengumpul sampah yang dianggap lebih efektif dan efisien, terutama dalam mendukung tercapainya universal akses di sektor persampahan.
Prediksi Erosi di Wilayah Jawa Timur
Authors: Taslim Rhoshandhayani Koesiyanto , Mandala Marga , Indarto Indarto 
Published: September 2019

Erosion is an event of eroding soil that occurs naturally. However, human activities that change land use from natural (forestry, plantation, rural areas) to urban features can alter the erosion processes. Rapid calculation of erosion level for the wide area is necessary for the management and conservation planning. This research aims to analyze the erosion level in East Java area using USLE (Universal Soil Loss Equation) and GIS. The erosivity factor (R) is calculated from rainfall data. Vegetation factor (C) and the conservation factor (P) estimated from land use map. The length and slope factor (LS) are calculated from the ASTER GDEM2, and the erodibility factor (K) is obtained from interpretation of soil map. Furthermore, all factors were analysed to calculate erosion rate. The result shows that the average erosion rate in East Java regions is 10,30 tons/ha/year. The result also show that 78,71% area of East Java is classified as very low erosion rate (0-15 tons/ha/year); 10,75% classified as low erosion rate (15-60 tons/ha/year); 6,39% classified as moderate erosion rate (60-180 tons/ha/year); and 2,83% is severe type (180-480 tons/ha/year). Only 1,31% from the total area is classified as very severe erosion rate (>480 tons/ha/year). The result also shows that USLE can be used to facilitate rapid erosion prediction for wide area.
Muscle Activation Patterns During Variable Resistance Deadlift Training With and Without Elastic Bands
Authors: Heelas Thomas , Theis Nicola , Hughes Jonathan D. 
Published: September 2019

Abstract
Heelas, T, Theis, N, and Hughes, JD. Muscle activation patterns during variable resistance deadlift training with and without elastic bands. J Strength Cond Res 35(11): 3006–3011, 2021—The purpose of this study was to determine the effects of band-assisted variable resistance training on muscular activity in the lower limbs and barbell kinematics during the concentric phase of the deadlift. Fifteen resistance trained men (mean ± SD: 28.7 ± 9.3 years; 1.80 ± 0.90 m; 92.5 ± 15.1 kg) performed 6 deadlift repetitions during 4 loading conditions: 100-kg bar (no band), 80-kg bar with 20-kg band tension (B20), 75-kg bar with 25-kg band tension (B25), and 70-kg bar with 30-kg band tension (B30). Muscle activity from the medial gastrocnemius (MG), semitendinosus (ST), vastus medialis (VMO), vastus lateralis (VL), and gluteus maximus (GM) were recorded using surface electromyography during the concentric phase of the lift and expressed as a percentage of each muscle's maximal activity, recorded during a maximal isometric contraction. Barbell power and velocity were recorded using a linear position transducer. Electromyography results showed that muscle activity significantly decreased as band resistance increased in the MG and ST (p < 0.05) and progressively decreased in the GM. No changes were observed for the VMO or VL. Peak and mean bar velocity and power significantly increased as band resistance increased. Performing the deadlift with band-assisted variable resistance increases bar power and velocity, while concurrently decreasing muscle activation of the posterior chain musculature. Practitioners prescribing this exercise may wish to include additional posterior chain exercises that have been shown to elicit high levels of muscle activation.
Disentangling Hippocampal and Amygdala Contribution to Human Anxiety-Like Behavior
Authors: Bach Dominik R. , Hoffmann Martina , Finke Carsten , Hurlemann Rene , Ploner Christoph J. 
Published: September 2019

Anxiety comprises a suite of behaviors to deal with potential threat and is often modeled in approach–avoidance conflict tasks. Collectively, these tests constitute a predominant preclinical model of anxiety disorder. A body of evidence suggests that both ventral hippocampus and amygdala lesions impair anxiety-like behavior, but the relative contribution of these two structures is unclear. A possible reason is that approach–avoidance conflict tasks involve a series of decisions and actions, which may be controlled by distinct neural mechanisms that are difficult to disentangle from behavioral readouts. Here, we capitalize on a human approach–avoidance conflict test, implemented as computer game, that separately measures several action components. We investigate three patients of both sexes with unspecific unilateral medial temporal lobe (MTL) damage, one male with selective bilateral hippocampal (HC), and one female with selective bilateral amygdala lesions, and compare them to matched controls. MTL and selective HC lesions, but not selective amygdala lesions, increased approach decision when possible loss was high. In contrast, MTL and selective amygdala lesions, but not selective HC lesions, increased return latency. Additionally, selective HC and selective amygdala lesions reduced approach latency. In a task targeted at revealing subjective assumptions about the structure of the computer game, MTL and selective HC lesions impacted on reaction time generation but not on the subjective task structure. We conclude that deciding to approach reward under threat relies on hippocampus but not amygdala, whereas vigor of returning to safety depends on amygdala but not on hippocampus.SIGNIFICANCE STATEMENTApproach–avoidance conflict tests are widely investigated in rodents, and increasingly in humans, to understand the neural basis of anxiety-like behavior. However, the contribution of the most relevant brain regions, ventral hippocampus and amygdala, is incompletely understood. We use a human computerized test that separates different action components and find that hippocampus, but not amygdala, lesions impair approach decisions, whereas amygdala, but not hippocampus, lesions impair the vigor of return to safety.
Path Analysis of Blood Glucose Determinant on Diabetes Mellitus Patients through Intervening Variables of Medication Adherence
Authors: Kasmini Handayani Oktia Woro , Lindasari Pamela , Rahayu Sri Ratna , Yuniastuti Ari , Nugroho Efa 
Published: September 2019

The prevalence of DM patients in Indonesia in 2013 has increased compared to 2007. The non- adherence of patients in undergoing treatment therapy is one of the drug therapy problems (DTP) that needs special attention. The purpose of the study was to obtain the results of an analysis of direct and indirect relationships related to knowledge, attitudes, family support, and adherence to taking medication for blood glucose levels in patients with DM of type II. Research with correlation analytic research design, with a population of all DM patients of type II with outpatient care in the Sleman region, DIY, were 530 people. The sample was determined by the proportionate stratified random sampling technique of 119 people. The independent variables include knowledge, attitude, family support, while the dependent variable is blood glucose levels in patients with DM of type II and the intervening variable is adherence with taking medication. This study uses path analysis techniques. The results of this study draw conclusions, knowledge, attitudes, family support and medication adherence to DM patients with directly influence blood glucose levels. Apart from knowledge, attitudes and family support through adherence to taking drugs indirectly affect blood glucose levels.
Food Insecurity and Health Care Use
Authors: Peltz Alon , Garg Arvin 
Published: September 2019

BACKGROUND AND OBJECTIVES:
Fifteen percent of US children live in households with inadequate food. Children who are food insecure often experience worse physical, emotional, and developmental health outcomes. Authors of previous studies have not examined the quality and cost implications of food insecurity in children.

METHODS:
This is a retrospective study of 7959 nationally representative US children (aged 1–17 years) in the 2016 Medical Expenditure Panel Survey. Households with food insecurity were identified by ≥3 positive responses to the 30-day, 10-item US Food Security Survey. Main outcomes were annual health expenditures and quality of care indicators: emergency department (ED) and inpatient use, primary care and specialist visits, routine medical and dental care, patient experience measures, and school absenteeism. Logistic and 2-part regression models were constructed to estimate outcomes conditional on sociodemographic and medical covariates.

RESULTS:
Children in households with food insecurity were more often publicly insured and had special needs compared with all other children. In multivariable logistic regression, household food insecurity was associated with significantly higher adjusted odds of an ED (adjusted odds ratio [aOR] = 1.37) or primary care treatment visit (aOR = 1.24) during the year. Household food insecurity was associated with significantly higher school absenteeism (aOR = 1.74) and lower access to care for routine (aOR = 0.55) or illness (aOR = 0.57) care. There were no differences in annual health expenditures, hospitalizations, or receipt of routine medical or dental care.

CONCLUSIONS:
Household food insecurity is associated with higher ED use and school absenteeism and lower access to care; however, it was not associated with higher annual health expenditures in children.
Food Insecurity and Child Health
Authors: Thomas Margaret M.C. , Miller Daniel P. , Morrissey Taryn W. 
Published: September 2019

OBJECTIVES:
Food insecurity is an important public health problem facing children in the United States. Although a number of previous studies suggest that food insecurity has negative impacts on health, these studies have not dealt thoroughly with issues of selection bias. We use propensity scoring techniques to approximate the causal effects of food insecurity on children’s health and health care use outcomes.

METHODS:
We use nationally representative data from the 2013–2016 waves of the National Health Interview Study (N = 29 341). Using inverse probability of treatment weighting, a propensity scoring method, we examine a broad range of child health outcomes and account for a comprehensive set of controls, focusing on a sample of children 2 to 17 years old.

RESULTS:
Household food insecurity was related to significantly worse general health, some acute and chronic health problems, and worse health care access, including forgone care and heightened emergency department use, for children. Compared to rates had they not been food insecure, children in food-insecure household had rates of lifetime asthma diagnosis and depressive symptoms that were 19.1% and 27.9% higher, rates of foregone medical care that were 179.8% higher, and rates of emergency department use that were 25.9% higher. No significant differences emerged for most communicable diseases, such as ear infections or chicken pox, or conditions that may develop more gradually, including anemia and diabetes.

CONCLUSIONS:
Policies used to reduce household food insecurity among children may also reduce children’s chronic and acute health problems and health care needs.