bluuebunny/crossref_metadata_2025_split huggingface dataset:
MAGnesium‐based bioresorbable scaffold and vasomotor function in patients with acute ST segment elevation myocardial infarction: The MAGSTEMI trial: Rationale and design
Authors: Brugaletta Salvatore , Cequier Angel , Alfonso Fernando , Iñiguez Andrés , Romaní Sebastian , Serra Antonio , Salinas Pablo , Goicolea Javier , Bordes Pascual , del Blanco Bruno García , Hernández‐Antolín Rosana , Pernigotti Alberto , Gómez‐Lara Josep , Sabaté Manel 
Published: September 2018

AbstractAimUse of a Bioresorbable Scaffolds (BRS) either in clinical practice or in the setting of an acute myocardial infarction (MI) is controversial. Despite an overall high rate of thrombosis, vascular healing response following BRS implantation tend to superiority as compared to metallic drug‐eluting stent in ST‐segment elevation myocardial infarction (STEMI) patients.We sought to compare the in‐stent/scaffold vasomotion between metallic BRS and sirolimus eluting stent (SES) at 12‐month angiographic follow‐up in the setting of patients with STEMI treated by primary PCI.Study designThis is an investigator‐driven, prospective, multicenter, randomized, single blind, two‐arm, controlled trial (ClinicalTrials.gov number: NCT03234348). This trial will randomize ~148 patients 1:1 to SES or BRS. Primary end‐point is the in‐stent/scaffold change in mean lumen diameter after nitroglycerin administration at 12‐month angiographic follow‐up. Besides, patient‐oriented combined endpoint of all‐cause death, any MI, and any revascularization, together with scaffold/stent thrombosis rate and device‐oriented endpoint of cardiac death, target vessel (TV)‐MI and TVR at 1 year will be also evaluated. Clinical follow‐up will be scheduled yearly up to 5 years.ConclusionThis trial will shed light on the vascular vasomotion following BRS implantation in the complex scenario of STEMI.
Feasibility and clinical outcome of rotational atherectomy in patients presenting with an acute coronary syndrome
Authors: Allali Abdelhakim , Abdelghani Mohammad , Mankerious Nader , Abdel‐Wahab Mohamed , Richardt Gert , Toelg Ralph 
Published: September 2018

AbstractObjectivesWe aimed to investigate the feasibility, safety, and outcome of rotational atherectomy (RA) in the setting of acute coronary syndrome (ACS).BackgroundLimited data are available on the use of RA in patients presenting with ACS.MethodsThis analysis is from an observational registry, which enrolled all consecutive patients undergoing RA in a tertiary center. Between 2002 and 2015, 433 patients with stable coronary artery disease (SCAD) were treated with RA. Within the same period, 108 patients with ACS (8 STEMI and 100 NSTE‐ACS) were treated with RA. Procedural success was similar between the ACS and the SCAD groups (96.6% vs. 96.4%, P = 0.90), and no significant difference was observed in procedural complications (slow‐flow: 0.8% vs. 2.8%, P = 0.32; coronary dissection: 6.8% vs. 7.2%, P = 1.00; coronary perforation: 0.8% vs. 1.7%, P = 0.69). In‐hospital MACE rates were comparable (3.7% vs. 3.2%, P = 0.77). The risk of MACE within 24 months was higher in ACS patients (39.9% vs. 22.4%, log‐rank P = 0.002; HR: 1.39; 95% CI: 1.12–1.73; P = 0.003). Multivariable Cox regression analysis identified left ventricular ejection fraction (HR 0.97; 95% CI: 0.85–0.99; P = 0.001), treatment with a BMS (HR 2.22, 95% CI: 1.15–4.25, P = 0.02) or early generation drug eluting stent (HR 1.99; 95% CI 1.09–3.64; P = 0.03), as well as ACS presentation (HR 1.53; 95% CI: 1.02–2.29; P = 0.04) as predictors of MACE at two years.ConclusionsRA is technically feasible and safe in high risk patients presenting with ACS. However, successful application of RA did not mitigate the higher rate of long term cardiovascular events.
Radioprotective strategies for interventional echocardiographers during structural heart interventions
Authors: Corrigan Frank E. , Hall Michael J. , Iturbe Jose Miguel , Condado Jose F. , Kamioka Norihiko , Howell Sharon , Thourani Vinod H. , Clements Stephen D. , Babaliaros Vasilis C. , Lerakis Stamatios 
Published: September 2018

AbstractObjectiveWe investigated radioprotective strategies for the interventional echocardiographer (IE) during structural heart interventions in comparison with the interventional cardiologist (IC).BackgroundStructural heart interventions are expanding in complexity with increased reliance on IE. Recent reports have demonstrated concerning exposure and higher radiation to the IE.MethodsWe monitored 32 structural interventions — 19 transcatheter aortic valve replacements (TAVR), 6 transcatheter mitral valve repairs, 5 paravalvular leak closures, and 2 atrial septal defect closures. Seventeen utilized transesophageal echocardiography (TEE) while 15 used transthoracic echocardiography (TTE). Members of the IC and IE teams wore multiple dosimeters on different sites of the body to measure radiation dose to the total body, lens of the eye, and hand. During each case, IE utilized dedicated radiation shielding.ResultsMean doses were higher for the primary IC than the primary IE: IC#1–99, 222, 378; IE#1–48, 52, 416 (body, lens, and hand doses in μSv). IE radioprotective strategies were able to reduce body and lens doses compared to IC during both TTE and TEE‐guided procedures. Hand equivalent dose remained higher for the IE driven by exposure during TEE‐guided procedures (IC#1 294 vs. IE#1 676 μSv). In a subgroup using radioprotective drapes during TTE‐guided TAVR, IC dose was reduced without effect on the IE.ConclusionsRadiation exposure during structural heart interventions is concerning. With dedicated shielding, IE received lower doses to the body and lens than IC. Further optimization of structural suite design and shielding is needed.
One‐stop shop: Simultaneous direct mitral annuloplasty and percutaneous mitral edge‐to‐edge repair in a patient with severe mitral regurgitation
Authors: Braun Daniel , Näbauer Michael , Massberg Steffen , Hausleiter Jörg 
Published: September 2018

AbstractPercutaneous edge‐to‐edge repair of severe mitral regurgitation has been established as an alternative treatment option for patients at high risk for cardiac surgery. More recently, the introduction of the Cardioband system enabled percutaneous direct annuloplasty. Here, we present a case of simultaneous percutaneous direct annuloplasty with edge‐to‐edge repair. Moreover, annuloplasty did facilitate clip implantation bei approximating the anterior and posterior mitral leaflet. In conclusion, the combination of direct annuloplasty with edge‐to‐edge repair is feasible in a single procedure.
Novel approach to coronary artery perforation repair
Authors: Ingrassia Joseph , Youn Young Jin , Lee Juyong , Azrin Michael , Khalid Salman 
Published: September 2018

AbstractCoronary artery perforation (CAP) during percutaneous coronary intervention is a rare but serious complication. Treatment options of CAP include prolonged balloon inflation, covered stent, and coil embolization. Although most cases of CAP can be treated with prolonged balloon inflation, some cases, especially Ellis grade III CAP require covered stents or coiling. Covered stents may require a large bore guide catheter and have a high rate of restenosis, which can be a limiting factor in patients with severe peripheral arterial disease. Coil embolization is generally used in distal CAP because coiling in the proximal vessels results in a large territory of infarction. We present a case of an Ellis grade III CAP during rotational atherectomy successfully treated with a novel coiling technique whereby the thrombogenic coil extends through the perforation outside of the vessel, and the intraarterial portion of the coil is excluded from the lumen by drug‐eluting stent placement over the proximal portion of the coil.
Study of biodegradable occluder of atrial septal defect in a porcine model
Authors: Li Bo‐Ning , Xie Yu‐Mei , Xie Zhao‐Feng , Chen Xian‐Miao , Zhang Gui , Zhang De‐Yuan , Liu Xiang‐Dong , Zhang Zhi‐Wei 
Published: September 2018

AbstractObjectiveTo evaluate the safety and feasibility of a modified poly(l‐lactic acid) (PLLA) atrial septal defect (ASD) occluder.MethodsForty‐five piglets were divided into two groups: an experimental group (n = 27) and a control group (n = 18). The experimental group underwent percutaneous implantation of a modified PLLA ASD device while the control group underwent percutaneous implantation of a widely used metal ASD device. X‐ray imaging, transthoracic echocardiography (TTE), electrocardiogram (ECG), histopathology and electron microscopic examination were performed at 7 days, 1, 3, 6, and 12 months after implantation.ResultsTwenty‐seven experimental piglets and 18 control piglets were all successfully implanted with modified biodegradable and metal ASD devices, respectively. While both devices exhibited very good occluding effects, the modified PLLA ASD devices were completely endothelialized at 3 months after implantation, and the endothelialization appeared to be more complete compared to the control group. Degradation of the PLLA devices was noted at 12 months follow‐up with no loss of integrity at the atrial septum.ConclusionThis animal model with implanting of the occluders was effective and not associated with complications. The modified PLLA ASD devices are more controllable and practical than our previous devices. The implanted devices demonstrated good endothelialization and degradability in short and moderate term follow‐up. Long‐term studies are now underway to further evaluate the biodegradability of this novel device.
Caffeine content of pre‐workout supplements commonly used by Australian consumers
Authors: Desbrow Ben , Hall Susan , O'Connor Helen , Slater Gary , Barnes Katelyn , Grant Gary 
Published: September 2018

AbstractThe stimulant properties of caffeine are often promoted in pre‐workout supplements (PWS) to assist with training, reduce the perception of fatigue, and for some brands, assist body fat loss. While manufacturers of PWS often indicate the inclusion of significant amounts of caffeine, no independent verification of the caffeine content of these products exists. The aim of this investigation was to independently assess the caffeine content of popular PWS in Australia and compare these values to nutrition information panel data. Fifteen PWS were tested for their caffeine content (both within and between batches of the same product). The caffeine content of selected PWS ranged from 91 to 387 mg·serve−1. Only 6 of the 15 PWS nutrition information panels included details on caffeine content. The percent of caffeine present ranged from 59% to 176% of packaging claims. All but one PWS contained a variation of caffeine within and between batches that was considered “practically” significant (ie, ≥40 mg·serve−1 variation). Consumers are likely to be exposed to large and variable caffeine doses if ingesting PWS. Product information panels do little to improve consumer awareness of likely caffeine intakes.
Effects of slightly acidic electrolyzed water on the microbial quality and shelf life extension of beef during refrigeration
Authors: Sheng Xiaowei , Shu Dengqun , Tang Xiajun , Zang Yitian 
Published: September 2018

AbstractStudies on slightly acidic electrolyzed water (SAEW) for decontamination and shelf life extension of beef are limited. This study aimed to evaluate the effects of SAEW and tea polyphenols (Tpp) on the microbiological, physicochemical, and sensory qualities of fresh beef during storage. The changes in total viable count, thiobarbituric acid content, pH, total volatile basic nitrogen, and sensory scores revealed that the required quality standard of the beef treated with distilled water, Tpp, and SAEW was maintained for up to 6–8, 12–14, and 14–16 days, respectively. These results demonstrated that SAEW could effectively extend the shelf life of beef in comparison with that of other treatments. However, there were no significant differences (p > 0.05) between the untreated and SAEW‐treated group in the content of thiobarbituric acid, suggesting that SAEW does not possess antioxidant activity. Therefore, further studies are required to increase its antioxidant activity. This study suggests that SAEW treatment is an effective and promising method to prolong the shelf life of beef by around 8 days at 4°C.
Physiological strain and decision making affected by different cooling tactics following live‐fire training
Authors: Hemmatjo Rasoul , Zare Sajad , Hajaghazadeh Mohammad , Allahyari Teimour , Kazemi Reza 
Published: September 2018

AbstractMultiple factors, including different environmental, physical, and psychophysiological agents, influence firefighters’ health and safety in real fire and rescue operations. This experimental study investigated the effect of live‐fire training and cooling strategies on both physiological response and decision making. Twenty‐three healthy male firefighters performed live‐fire tasks in four separate conditions: namely rest or without cooling method (WCM), cool vest (CV), forearm immersion (FI), and cool vest and forearm immersion (CV + FI). Cooling effects of the employed interventions were evaluated based on heart rate (HR), tympanic temperature (TT), and Iowa gambling task (IGT) scores. At the end of the four experimental conditions, HR and TT increased, whereas IGT scores as a measure of decision making decreased relative to baseline. HR (beats per minute) and TT (°C) were significantly lower at the end of the experiment in the CV, FI, and CV + FI compared with the WCM conditions. There was no significant difference in Iowa scores between experimental conditions. These consequences demonstrate that live‐fire tasks are effective in raising the physiological and decision‐making responses following firefighting activities. It is concluded that CV, FI, and CV + FI were more effective than the WCM in attenuating physiological responses and decision making during live‐fire training.
Varieties of being “social”: Cognitive work analysis, symbolic interactionism, and sociotechnical systems
Authors: Kant Vivek 
Published: September 2018

AbstractCognitive work analysis (CWA) is a prominent framework for analyzing and modeling cognitive work in sociotechnical systems. It derives from both engineering‐ and psychological‐based approaches for the study of human knowing and acting in technological contexts. Nonetheless, in its current form, the social dimension of CWA is underdeveloped. This study extends CWA as a requirements gathering framework for sociotechnical systems in terms of a broader meaning of “social,” derived from interpretive sociology. Specifically, this is achieved by providing convergence to the approaches of CWA, symbolic interactionism (SI) and sociotechnical systems. To achieve this convergence, CWA is extended in two significant ways. First, deriving from a hermeneutic (interpretive) viewpoint of SI, the ethnographic analysis is conducted. Along with this first extension, the fourth phase of CWA, Social, Organizational and Cooperation Analysis, is also extended using a hermeneutic mesh. These various concepts are demonstrated using an example of research in the work domain of small‐scale (micro and nano) robotics.
Optimization of user experience in interaction design through a Taguchi‐based hybrid approach
Authors: Li Yongfeng , Zhu Liping 
Published: September 2018

AbstractUser experience (UX), which encompasses all aspects of a user’s interaction with an interactive product, has been recognized as central to interaction design. This paper proposes a Taguchi‐based hybrid approach to realize the optimal UX design. In this approach, design analysis is first used to identify design patterns and UX characteristics. According to the results, a Taguchi experiment is conducted and the signal‐to‐noise ratios are computed. Subsequently, the preference weights for the UX characteristics are obtained by using analytical hierarchy process‐based group decision making. A multiperformance characteristic index is then defined based on the gray relational grade (GRG) obtained through gray relational analysis. On the basis of the GRG, the optimal design can be obtained. A mobile health application design was used to demonstrate the proposed approach. The results show that this approach can effectively enhance UX quality and be used as a universal design approach for optimizing UX.
How to foster frontline employee knowledge sharing within service‐oriented enterprises: Empirical evidence from China
Authors: Zhou Fei , Chen Qinlan , Wu Yenchun 
Published: September 2018

AbstractBased on the context of Chinese workplace, the present research aims to explore the combined effects of proactive personality, supervisor–subordinate guanxi (s–s guanxi), and leaders’ innovation expectations on the knowledge sharing of frontline employees (FLEs). Questionnaire data from a sample of 301 FLEs within service‐oriented enterprises in China were used in this study. The results show that proactive personality and leaders’ innovation expectations are both positively related to employees’ psychological empowerment and knowledge sharing, and s–s
guanxi significantly impacts psychological empowerment, but has a nonsignificant effect on knowledge sharing. This study expands the understanding of FLEs’ knowledge sharing behavior and enriches our understanding of the
guanxi construction process during the interaction between supervisors and subordinates.
The effects of short‐term and long‐term exposure to extreme cold environment on the body’s physiological responses: An experimental study
Authors: Saedpanah Keivan , Aliabadi Mohsen , Motamedzade Majid , Golmohammadi Rostam 
Published: September 2018

AbstractThere is little epidemiological data to make reliable conclusions about the effects of exposure to cold on the body’s physiological responses. The current study aimed to address this lacuna in the available research. The study sample consisted of 50 outdoor mechanic workers as a case group and 15 staff members as a control group used in the outdoor automechanic workshops. Air environmental factors, including dry‐bulb temperature and air velocity, were measured by the portable hot wire thermo anemometer in the workstation of each subject. The body’s physiological responses were also measured during daily activities in accordance with ISO 9886. Using Semmes–Weinstein monofilament, touch sensory tests were conducted for determining hands’ sensorineural functions. The baseline measurements showed the mechanic workers had lower finger sensation levels and finger skin temperatures than the control group (p < 0.05). This may be attributed to long‐term exposure to acute cold air during cold seasons. However, after short‐term exposure to extreme cold environment, the mechanic workers showed lower losses in finger skin temperatures and finger sensation levels than the control group (
p < 0.05). The findings confirmed that prolonged localized cold exposure among mechanic workers can result in localized habituation of vasoconstrictor responses.
Predictive value of breast magnetic resonance imaging in detecting mammographically occult contralateral breast cancer: Can we target women more likely to have contralateral breast cancer?
Authors: Susnik Barbara , Schneider Lisa , Swenson Karen K. , Krueger Janet , Braatz Christina , Lillemoe Tamera , Tsai Michaela , DeFor Todd E. , Knaack Monica , Rueth Natasha 
Published: September 2018

AbstractBackground and ObjectivesPreoperative breast magnetic resonance imaging (B‐MRI) staging in newly diagnosed breast cancer increases detection of synchronous contralateral findings, but may result in false‐positive outcomes. This study objective was to identify women more likely of having mammographically occult, MRI detected contralateral breast cancer (CBC).MethodsWe performed a retrospective review of patients who had preoperative B‐MRI prior to surgery from 2010 to 2015 and collected patient imaging and clinicopathologic data. Multivariate logistic regression was used to identify predictors of CBC.ResultsMRI resulted in contralateral findings in 201 of 1894 patients (10.6%). Overall 3.2% (60 of 1894) had synchronous CBC detected on B‐MRI. The majority of CBCs (n = 60) were stage 0 or IA (85.0%), hormone receptor positive (94.9%), human epidermal growth factor receptor 2 (HER2/neu) negative (89.7%), and low/intermediate pathological grade (87.2%). Women more likely to have CBC were older (P < .001), had lobular index cancer (P = .03), and estrogen receptor (ER)+ (P = .027) or progesterone receptor (PR)+ (P = .002) tumors. On multivariate analysis (receiver operating characteristic curve area = 0.75), PR + status (P = .022), and older age (P = .004) were predictive of CBC.ConclusionsPreoperative MRI is most effective in detecting early stage, hormone receptor‐positive CBC in older women.
Neutrophil to lymphocyte ratio is an independent predictor of outcome for patients undergoing definitive resection for stage IV melanoma
Authors: Kanatsios Stefanos , Melanoma Project Melbourne , Li Wai Suen Connie S. N. , Cebon Jonathan Simon , Gyorki David E. 
Published: September 2018

Background and ObjectivesThe aim of this study was to perform a retrospective analysis of survival rates and determine prognostic indicators for patients who underwent definitive surgical resection of stage IV melanoma.MethodsPatients included were those who underwent complete resection of metastatic melanoma. Data was analyzed using IBM SPSS 2.0. Survival estimates were derived from Kaplan‐Meier, log‐rank, and Breslow tests.ResultsThe study population (n = 95) consisted of 60 males and 35 females. Median overall survival (OS) from the first metastasectomy was 49 months (95% confidence interval, 31‐67 months). OS at 1, 2, and 5 years was 92%, 87%, and 50% respectively. Predictors of survival included clear surgical margins compared to patients with positive margins (median OS 53 vs 20 months,
P = .026). A preoperative neutrophil to lymphocyte ratio less than 5 experienced a median OS of 65 months compared to 15 months (
P = .006; multivariable analysis for OS: hazard ratio 3.590,
P = .009).ConclusionThis study's results are consistent with previous findings demonstrating favourable long‐term outcomes following selective resection of metastatic melanoma. In addition to achieving clear surgical margins, a low preoperative neutrophil to lymphocyte ratio was associated with improved outcomes. These factors may help identify surgical candidates.