bluuebunny/crossref_metadata_2025_split huggingface dataset:
ABCG2 GENE POLYMORPHISM IN PATIENTS WITH GOUT IN ZABAIKALSKY KRAI
Authors: Kushnarenko N. N. , Mishko M. Yu. , Medvedeva T. A. , Vitkovsky Yu. A. 
Published: June 2019

Aim. To study the frequency distribution of alleles and genotypes of the C421A locus (rs2231142, Q141K) of the ABCG2 gene in patients with gout and to evaluate their association with the risk of the disease development.Methods. 80 patients (69 men and 11 women) with gout (mean age 54.8±12.4 years) were examined. Gout was diagnosed according to the ACR/EULAR classification criteria, 2015. The material for the study was DNA isolated from leukocytes of the whole peripheral blood. All patients were genotyped to detect polymorphism of the C421A locus (rs2231142, Q141K) of the ABCG2 gene. Statistical data processing was performed using Statistica 10.0 statistical software package.Results. The results of the study of the C421A polymorphism (rs2231142, Q141K) of the ABCG2 gene demonstrated a high frequency of mutant A (χ2 = 5.58, p = 0.018, OR = 3.5, CI95% = 1.16–10.52) genotypes C/A (χ2 = 5.03, p = 0.024, OR = 3.5, CI95% = 1.11–10.98) among patients with gout compared with the control group. This fact indicates the significance of the ABCG2 gene rs2231142 locus in the development of gout and allows us to consider the carriage of the minor (A) allele and the C/A genotype as a molecular genetic factor in the development of the disease. The carriage of the wild-type allele (C) and the C/C genotype has a protective character, reducing the risk of developing the disease by 3.5 times.Conclusion. ABCG2 C421A (rs2231142, Q141K) is associated with a high risk of developing gout among population of Zabaikalsky Krai. ABCG2 gene polymorphism can be considered as a genetic predictor of a higher risk of developing gout.
OPPORTUNITIES AND FUTURE PERSPECTIVES FOR REMOTE MONITORING OF PATIENTS WITH IMPLANTED DEVICES
Authors: Lomidze N. N. , Vaskovskiy V. A. , Yashkov M. V. , Artukhina E. A. , Revishvili A. Sh. 
Published: June 2019

Today implantable cardiac devices (ICD) are advanced therapeutic and preventive tools ensuring the collection and transmission of statistical and diagnostic patient data. The information obtained from implanted devices allows analyzing patients’ condition, selecting optimal treatment strategy, predicting and preventing possible complications. The number of ICD recipients is rapidly growing. Over 1,000 devices per 1 million population are implanted in Europe and the US annually. In the Russian Federation this number reaches 300 devices per 1 million population. Routine medical checkups of patients with ICD should be performed 2–4 times a year, with an average length of about 20 minutes. It means that only in the Russian Federation physicians will have to work 20–40 thousand extra hours with a tendency towards its increase as this figure will grow simultaneously with growing patients’ number. Remote monitoring (RM) technologies may solve this problem. In 2000 Biotronik AG developed the world's first system for remote monitoring of anti-arrhythmic devices called the “Home Monitoring” system. It is based on the mobile RM of patients who received ICD. The information collected by the devices is transmitted to a special service center via mobile communication networks and after processing, the information is transferred to a physician’s website along with a text message and a fax. The information is instantly delivered from a patient to a physician. A closed information network "patient-service center-physician" was developed for the hospitals and their patients, providing a novel advanced monitoring and timely treatment of the patient.
Characteristic features of pregravid preparation of married couples with burdened reproductive anamnesis, taking into account the results of in-depth study of genital microbiocenosis
Authors: Sandakova E. A. , Savelyeva N. V. , Rakitina Yu. V. , Karpunina T. I. , Gosteva E. О. 
Published: June 2019

Aim. To optimize the pregravid preparation of married couples on the basis of in-depth study of genital microflora and correction of genital microbiocenosis.
Materials and methods. One hundred twenty eight married couples were examined regarding their pregravid preparation. The study included clinical investigation, colposcopy, USI of small pelvis organs, bacterioscopic investigation of vaginal isolate and urethral smear (men), bacteriological investigation of cervical mucus and ejaculate, genetic typing of strains isolated. Uterine cervix biopsy and aspiration endometrial biopsy was performed according to indications.
Results.There was detected a strong positive correlation between bacteriospermia, chronic cervicitis and chronic endometritis (r > 0.6). It proves the role of bacteriospermia in development of the ascending infection of endocervix and endometrium. At the same time, opportunistic microflora in a married couple, revealed in the presence of bacteriospermia and chronic cervicitis, in 80 % of cases is identical that makes it possible to draw an analogy with sexually transmitted infections. In most cases, chronic cervicitis was shown to be a visible marker of chronic endometritis.
Conclusions. A thorough study of genital mucosa microbiocenosis, implemented in a married couple with burdened reproductive anamnesis at the stage of pregravid preparation, permits to raise its efficiency.
Sensitization rate and sum of sige-antibodies to apple grades of various colours. Association of these indices with severity of atopic dermatitis
Authors: Prilutsky A. S. , Tkachenko K. E. , Baranova O. V. , Sorokina O. V. 
Published: June 2019

Aim. To assess the rate of sensitization to the grades of apples of various colours and analyze the association of the obtained indices and total sIgE levels of these grades with the severity of atopic dermatitis.
Materials and methods. The blood sera of 215 patients, suffering from alimentary allergy, were studied. The detection rate of sensitization and that of specific immunoglobulin E (sIgE) concentration sum to allergens of apple grades with various coating colours as well as the association of these indices with the degree of severity of atopic dermatitis (AD) was analyzed. Test-systems were used for immune-enzyme analysis of production. Statistical analysis of the obtained results was performed using the program “MedStat” (Donetsk).
Results. It was shown that the detection rate of sensitization to the grades with mixed red colour is reliably higher (p < 0.001) compared to the grades without coating colour. The degree of AD severity correlates with the total quantity of apple grades, to which sensitization has been revealed (p < 0.01), with the quantity of grades with mixed red colour, to which sensitization has been found (p < 0.01) and with sIgE sum to the grades with mixed red colour (p < 0.01). Reliable differences (p = 0.006) in the degree of severity of atopic dermatitis among persons, sensitized to apple grades and with no sensitization to this fruit were established.
Conclusions.The obtained data are to be used when choosing a diet and correcting it for persons with alimentary allergy and atopic dermatitis.
Short-and long-term results of distal pancreatectomy
Authors: Barykov V. N. , Istomin A. G. , Abdrashitov R. R. , Ryzhikh A. S. 
Published: June 2019

Aim. To assess the results of distal pancreatectomy for malignant and benign tumors and chronic pancreatitis complications.
Materials and methods. Forty-seven patients, who underwent distal pancreatectomy, were under observation during the period from 01.01.2008 to 28.02.2019.
Results. The long-term results of surgical treatment demonstrated the following complications: pancreatic fistulas – 15 % of observations, pancreatogenic diabetes mellitus – 12.7 %, subphrenic abscesses – 10 %. In the long-term period after the surgery – from 10 years and not less than one year – 30 patients were followed up, constituting 63.8 % of the total number.
Conclusions. To prevent complications in the form of pancreatic fistula with pathological Wirsung duct dilatation more than 4–5 mm in diameter, it is necessary to form anastomosis between the pancreatic stump and the small bowel.
Physiological and neuropsychological features of adaptation to training in conditions of Western Ural among foreign students from India
Authors: Koryukina I. P. , Kulesh T. A. , Arbuzova T. P. , Zueva T. V. , Petrischeva A. V. , Shulkina S. G. , Cherkasova V. G. , Karakulova Yu. V. , Seksyaev N. E. , Chainikov P. N. 
Published: June 2019

Aim. To study the physiological and neuropsychological features of adaptation to training in conditions of Western Ural among foreign students from India.
Materials and methods. The object of study – first-year foreign students from India and Russian students of E.A. Vagner Perm State Medical University (52 and 47 persons, respectively). There were studied the parameters of physical development and cardiovascular system, including those with loading, as well as hypoxia tolerance tests. The following indices were calculated: body mass index (BMI), Robinson and Kerdo index, cardiac performance index (CPI), strength index (SI). The health level was calculated by G.L. Apanasenko. Peculiar features of students’ neuropsychical status were studied using the following surveys: Spilberger-Hanin Anxiety Scale to determine personal and situational anxiety, Beck Depression Inventory (BDI), scale for assessment of depression symptoms CES-D, scale for assessment of quality of life SF-36 with subscales, Epworth Sleepiness Scale, asthenia scale MFI-20, CAM (cenesthesia, activity, mood).
Results. Among Indian students, dispersion of BMI values and lower dynamometry indices were established. Hypoxia tolerance in the groups was similar. Kerdo index values in the group of Indian students showed a tendency to vagotonia, in the control group – to normotonia. No significant differences in other indices were registered. Health level in the studied groups was in “dangerous” zone regarding the risk for development of chronic noninfectious diseases, especially in the group of Indian students. The situational anxiety level by Spilberg 1 scale, and depression level by CES-D scale were reliably higher in the group of foreign students (p < 0.0001). SF-36 PF and SF-36 GH scores in Indian students were reliably lower versus Russian. Psychical component of health by SF-36 MH subscale was significantly higher in Russian students.
Conclusions. Among first-year students from India, who study at Perm State Medical University, there is observed a complex adaptive syndrome, which needs to be taken into account and corrected to prevent deadaptation disorders and raise progress in studies as well as quality of life and health status.
Allergic morbidity in patients of different age groups
Authors: Minaeva N. V. , Devyatkova E. A. 
Published: June 2019

Aim. To analyze the regularities of the prevalence of allergic diseases in patients of different age groups.
Materials and methods. Epidemiological indices of allergic diseases were studied in children, adolescents, adults and elderly persons using official statistical data.
Results. The general and primary morbidity, allergopathology structure and its dynamics were evaluated in patients of different age groups. The data, obtained in Perm Krai and the Russian Federation, were compared.
Conclusions. The level of atopic dermatitis (AD) is the highest in children, allergic rhinitis (AR) – in adolescents, bronchial asthma (BA) – in adolescents and elderly persons. The cases of BA prevail in the structure of allergopathology in all age groups, besides children. Among children AD cases make 50.5 % of all allergic diseases. In dynamics, AD has a tendency to reduction of general morbidity in all age groups, BA – in children; a tendency to elevation is typical for AR in children and adolescents, BA – in adolescents, adults and elderly persons.
Proposta de Ação Interdisciplinar para o Ensino de Trigonometria no Ensino Fundamental
Authors: Rizzon Bruna Moresco , Marchioro Fernanda , Giovannini Odilon 
Published: June 2019

O presente artigo tem como objetivo propor uma Unidade de Ensino Potencialmente Significativa (UEPS) sobre trigonometria para o nono ano do ensino fundamental relacionando assuntos da atualidade com o cotidiano da sala de aula. Para a realização desta UEPS os alunos serão estimulados ao trabalho em equipe, ao levantamento de dados, a utilização de artefatos tecnológicos e a realização de atividades que envolvem o raciocínio lógico. As disciplinas envolvidas nesta proposta são matemática, biologia, geografia e língua portuguesa que, trabalharão de maneira interdisciplinar e a luz da teoria da aprendizagem significativa de Ausubel. http://dx.doi.org/10.18226/23185279.v7iss3p1
Avaliação da Sazonalidade da Qualidade da Água do Açude da Macela em Itabaiana/SE
Authors: Barbosa Alan de Gois , Santos Kelly Marina Silva , Michelan Denise Conceição de Gois Santos 
Published: June 2019

A Lei Federal 9.433 de 1997 tem como um de seus objetivos a garantia de água em quantidade e qualidade adequadas para os usos atuais e futuros. Para isso, devem ser atendidos requisitos mínimos de qualidade dispostos na legislação ambiental. Este trabalho busca avaliar a influência das estações seca e chuvosa na qualidade da água do Açude da Macela, em Itabaiana, Sergipe. Para isso, foi aplicado o Índice de Conformidade ao Enquadramento (ICE), diferenciando os períodos seco e chuvoso. O ICE foi calculado através dos parâmetros de pH, OD, DBO, Nitrogênio Amoniacal, Fósforo e Coliformes Termotolerantes em três pontos de monitoramento. De modo complementar, foram aplicados testes estatísticos não paramétricos para as estações seca e chuvosa. Os resultados mostram que o Açude da Macela não atende aos padrões de qualidade estabelecidos para as Classes 1, 2 e 3 de água doce, bem como tem sua qualidade piorada no período chuvoso. http://dx.doi.org/10.18226/23185279.v7iss3p24
Avaliação dos níveis de dióxido de nitrogênio e ozônio na Universidade do Vale do Taquari (Univates) utilizando amostradores passivos de baixo custo
Authors: Jung Heinen Carolina , De Almeida Silva Maria Cristina 
Published: June 2019

O crescimento urbano e industrial vem agravando a qualidade do ar, provocando danos ao meio ambiente e à saúde humana. Uma alternativa para o monitoramento dos poluentes atmosféricos é a utilização de amostradores passivos, construídos a partir de materiais de baixo custo. O presente estudo busca analisar, por meio da construção de amostradores passivos de baixo custo, os níveis de liberação de 2 poluentes atmosféricos – Dióxido de Nitrogênio (NO2) e Ozônio (O3). Os amostradores foram alocados em 8 diferentes pontos da Universidade do Vale do Taquari – Univates – Lajeado/RS, escolhidos considerando o fluxo de veículos e pessoas. As campanhas de amostragem foram realizadas de forma trimestral, abrangendo um período aproximado de 1 ano, com exposição variando de 7 a 8 dias. Os resultados da extração dos poluentes contidos nos amostradores foram obtidos através de espectrofotometria ultravioleta/visível, e seus respectivos valores calculados através da primeira Lei de Fick. As concentrações obtidas mostram que os índices de NO2 e O3 foram satisfatórios. A maior concentração de NO2 observada ocorreu durante a campanha de abril/17, com 13,5 µ/m³. Já o O3 apresentou valores superiores à 27 µ/m³, nas campanhas de novembro/16, julho e setembro/17. Além disso, realizou-se a espacialização dos dados de concentração obtidos durante o estudo, a fim de verificar a distribuição das mesmas pelo Campus. Esta espacialização apresentou melhores resultados com o método de interpolação Inverso da Distância ao Quadrado. Conforme o método utilizado, a maior área com concentração de NO2 é compreendida entre os pontos 1 e 4. Já as concentrações de O3 apresentaram maior variabilidade, sendo que as maiores concentrações obtidas ocorreram próximas ao ponto 5. Considerando os resultados obtidos, conclui-se que o método de amostragem passiva com materiais acessíveis é viável, podendo ser utilizado em diferentes locais. http://dx.doi.org/10.18226/23185279.v7iss3p32
Desempenho das etapas de tratamento de água, da estação de tratamento de água Poxim
Authors: Michelan Denise Conceição Gois Santos , Batista Isabela Ferreira , Batista Daniela Ferreira , Santos Débora de Gois , Mendonça Luciana Coelho , Lima Daniel Moureira Fontes 
Published: June 2019

A água para consumo humano deve atender aos padrões de potabilidade estabelecidos pela Portaria 2914 e Portaria de Consolidação nº 5 do Ministério da Saúde, assim cabe às Estações de Tratamento de Água (ETA) garantir que a mesma chegue ao destino final livre de contaminações. Para isso, a estação de tratamento convencional é composta por mistura rápida, floculação, decantação, filtração e saída da água clorada. Neste trabalho buscou-se avaliar o desempenho das etapas de tratamento na ETA Poxim, localizada em Sergipe, de forma a caracterizar a eficiência da qualidade da água quanto aos parâmetros cor aparente, turbidez e pH, com o intuito de verificar possíveis desvios de etapa no tratamento, de modo a proporcionar menor intervalo de tempo e consequentemente chegar na distribuição o mais rápido possível. Como resposta, verificou-se que, de modo geral, na unidade de mistura rápida e floculação, não ocorreu remoção de cor aparente e turbidez. A decantação e a filtração são as unidades do tratamento de água em que melhor ocorre a remoção desses parâmetros com eficiência significativa. Algumas amostras de água da saída do filtro não atenderam aos limites de parâmetros recomendados pela Portaria do Ministério da Saúde e os piores resultados coincidiram com o período chuvoso. Diante do exposto, não se sugere período viável em fase de tratamento da água que possa passar por desvios de etapa no tratamento de água. http://dx.doi.org/10.18226/23185279.v7iss3p7
REZAGO Y ABANDONO EDUCATIVO EN COLOMBIA: UN CAMBIO EN LA POLÍTICA PÚBLICA PARA LA EQUIDAD EDUCATIVA
Authors: Rojas Ladino Angela María 
Published: June 2019

RESUMEN. A partir de la universalización de la educación básica, secundaria y media se han presentado nuevos retos en materia educativa, los estados latinoamericanos, entre ellos el colombiano, deben enfrentar el reto de garantizar acceso y equidad a la educación para toda la población mediante diversos instrumentos de política pública, esto se dificulta ante las diversas desigualdades que sufren nuestros países, diferencias sociales, económicas, culturales, de género que se ven reflejadas en desigualdades educativas y segregación de los entornos escolares. Así, procesos de largo alcance como el rezago y el abandono escolar, evidencian un proceso de desenganche del entorno escolar el cual está influenciado por factores familiares y escolares, tales como las estrategias de bienestar del hogar y el clima educativo de las instituciones escolares. A partir de este contexto se hace una revisión y propuesta de la política pública colombiana en torno a las problemáticas educativas alrededor del desenganche escolar, con el objetivo de proponer, desde una perspectiva institucional, una hipótesis de intervención que aborde la raíz causal de los factores escolares del rezago y el abandono escolar. Con lo anterior se propone una política encaminada a cambiar la relación que las y los jóvenes tienen con la escuela, basada en la amplitud de la jornada escolar y el abordaje de la idea de escuela democrática. ABSTRACT. Since the universalization of various levels of education, new challenges had appeared. The Latin American states, including the Colombian, must face the challenge of ensuring access and equality in education for the entire population through different public policy instruments, this has been difficult due to the various social, economic, cultural, gender differences inequalities that our countries suffer, and these are reflected in educational inequalities and segregation of school environments. Thus, long-term processes such as academic lag and school dropout, evidence a process of disengagement from the school environment which is influenced by family and school factors, such as household welfare strategies and the educational climate of school institutions. Based on this, a review and proposal of the Colombian public policy regarding these educational problems is presented. From this context a review and proposal of the Colombian public policy is made around the educational problems around school disengagement, with the aim of proposing, from an institutional perspective, an intervention hypothesis that addresses the causal root of the school factors of dropout and academic lag. With the above, a policy aimed at changing the relationship that young people have with the school is proposed, based on the breadth of the school day and the approach of the idea of a democratic school.
ASPECTOS PSICOJURÍDICOS DA SÍNDROME ALCOÓLICA FETAL
Authors: Honorato Eduardo Jorge Sant'Ana , Da Silva Dalila Azevedo , Dos Santos Eunice Braga Borges , Sobral Alice , De Sousa Daniel Cerdeira 
Published: June 2019

RESUMO. Este estudo teve como objetivo realizar uma reflexão a cerca dos aspectos psicológicos e jurídicos da Síndrome Alcoólica Fetal – SAF com a intenção de construir um artigo científico. O método adotado foi uma revisão sistemática da literatura de onde se pode depreender que a SAF está se tornando um problema de saúde pública por ser uma das maiores causas de atraso mental. A SAF é uma doença para a qual não existe a cura, porém é totalmente passível de prevenção por meio da abstinência da ingestão de álcool durante o período de gestacional, quando o sistema nervoso está em processo de formação e desenvolvimento. Nesse momento a família surge como fator protetivo, pois a prevenção pode começar em casa junto da família onde as gestantes possam se sentir mais seguras, com a família acompanhando e suprindo as suas necessidades de desenvolvimento das potencialidades. É também, nesse contexto que o psicólogo pode contribuir trabalhando em equipe com os outros profissionais, não só no nível da avaliação como também no nível da intervenção psicológica. Neste estudo não houve definição se a quantidade álcool ingerido pela gestante tem relevância para o feto em desenvolvimento, porém, ficou claro que a completa abstinência dessa substância é de fundamental importância para a prevenção da SAF. ABSTRACT. This study aimed to carry out a reflection on the psychological and legal aspects of SAF with the intention of building a scientific article. The method used was a systematic review of the literature which can be seen that the SAF is becoming a public health problem because it is a major cause of mental retardation. SAF is a disease for which no cure but is completely preventable by withdrawal of alcohol intake during the gestation period when the nervous system is the formation and development process. At that point the family emerges as a protective factor because prevention can start at home with the family where the pregnant women they can be safer, with family watching and meeting their potentialities development needs is also in this context that the psychologist It presents with with its good practice, serving as a link connection between families and public policies to define strategies of integration and inclusion in society and interaction with other professionals. In this study there was no definition if the amount ingested alcohol by pregnant women is relevant to the developing fetus, but it was clear that the complete withdrawal of this substance is of fundamental importance for the prevention of FAS.