bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hydration and symptoms in the last days of life
Authors: Lokker Martine E , van der Heide Agnes , Oldenmenger Wendy H , van der Rijt Carin C D , van Zuylen Lia 
Published: August 2019

ObjectivesAt the end of life oral fluid intake is often reduced. Consensus about the most appropriate management for terminally ill patients with limited oral fluid intake is lacking. The objective of this study is to investigate to what extent the amount of fluid intake, preceding and during the dying phase, is related to the occurrence of death rattle and terminal restlessness.MethodsA multicentre prospective observational study was performed. Data on the occurrence of death rattle and terminal restlessness, fluid intake and opioid use of patients expected to die within a few days or hours were collected.Results371 patients were included. Death rattle was reported at least once in 40% (n=149) of patients during the dying phase. Death rattle occurrence was not associated with the amount of fluid intake during the days before dying. Terminal restlessness was reported in 26% of patients (n=96). Terminal restlessness was not associated with a lower amount of fluid intake during the days before dying. Terminal restlessness during the last 24 hours of life was associated with a higher amount of fluid (ie, >250 mL/day) during 48–25 hours before death.ConclusionsCaution with fluid intake to prevent development of death rattle does not seem to be necessary. Our study suggests that a higher amount of fluid intake during 48–25 hours before death may be associated with the occurrence of terminal restlessness during the last 24 hours of life. These results suggest that actively providing dying patients with artificial fluid may not be beneficial.
Lung cancer and end-of-life care: a systematic review and thematic synthesis of aggressive inpatient care
Authors: Bylicki Olivier , Didier Morgane , Riviere Frederic , Margery Jacques , Grassin Frederic , Chouaid Christos 
Published: August 2019

ObjectivesDespite recent advances in thoracic oncology, most patients with metastatic lung cancer die within months of diagnosis. Aggressiveness of their end-of-life (EOL) care has been the subject of numerous studies. This study was undertaken to evaluate the literature on aggressive inpatient EOL care for lung cancer and analyse the evolution of its aggressiveness over time.MethodsA systematic international literature search restricted to English-language publications used terms associated with aggressiveness of care, EOL and their synonyms. Two independent researchers screened for eligibility and extracted all data and another a random 10% sample of the abstracts. Electronic Medline and Embase databases were searched (2000–20 September 2018). EOL-care aggressiveness was defined as follows: 1) chemotherapy administered during the last 14 days of life (DOL) or new chemotherapy regimen during the last 30 DOL; 2) >2 emergency department visits; 3) >1 hospitalisation during the last 30 DOL; 4) ICU admission during the last 30 DOL and 5) palliative care started <3 days before death.ResultsAmong the 150 articles identified, 42 were retained for review: 1 clinical trial, 3 observational cohorts, 21 retrospective analyses and 17 administrative data-based studies. The percentage of patients subjected to aggressive therapy seems to have increased over time. Early management by palliative care teams seems to limit aggressive care.ConclusionsOur analysis indicated very frequent aggressive EOL care for patients with lung cancer, regardless of the definition used. The extent of that aggressiveness and its impact on healthcare costs warrant further studies.
Roles of individual differences and traffic environment factors on children’s street-crossing behaviour in a VR environment
Authors: Wang Huarong , Gao Zhan , Shen Ting , Li Fei , Xu Jie , Schwebel David C 
Published: August 2019

ObjectivePedestrian injuries are among the most common cause of death and serious injury to children. A range of risk factors, including individual differences and traffic environment factors, has been investigated as predictors of children’s pedestrian behaviours. There is little evidence examining how risk factors might interact with each other to influence children’s risk, however. The present study examined the independent and joint influences of individual differences (sex and sensation seeking) and traffic environment factors (vehicle speeds and inter-vehicle distances) on children’s pedestrian safety.MethodsA total of 300 children aged 10–13 years were recruited to complete a sensation-seeking scale, and 120 of those were selected for further evaluation based on having high or low sensation-seeking scores in each gender, with 30 children in each group. Children’s pedestrian crossing behaviours were evaluated in a virtual reality traffic environment.ResultsChildren low in sensation seeking missed more opportunities to cross and had longer start gaps to enter the roadway compared with those high in sensation seeking, and these effects were more substantial when vehicles were spread further apart but travelling slowly. Interaction effects between inter-vehicle distance and vehicle speed were also detected, with children engaging in riskier crossings when the car was moving more quickly and the vehicles were spread further than when the vehicles were moving quickly but were closer together. No sex differences or interactions emerged.ConclusionBoth sensation seeking and traffic environment factors impact children’s behaviour in traffic, and there are interactions between traffic speeds and inter-vehicle distances that impact crossing behaviour.
Understanding people’s ‘unrealistic optimism’ about clinical research participation
Authors: Cho Hae Lin , Miller David Gibbes , Kim Scott Y H 
Published: August 2019

BackgroundResearchers worry that patients in early-phase research experience unrealistic optimism about benefits and risks of participation. The standard measure of unrealistic optimism is the Comparative Risk/Benefit Assessment (CRBA) questionnaire, which asks people to estimate their chances of an outcome relative to others in similar situations. Such a comparative framework may not be a natural way for research participants to think about their chances.ObjectiveTo examine how people interpret questions measuring unrealistic optimism and how their interpretations are associated with their responses.MethodsUsing an early-phase cancer trial vignette, we administered the CRBA to 297 adults from the general public. They estimated their comparative chances of risk and benefit (7-point scale: −3 less likely to +3 more likely), then provided rationales for their estimates.ResultsFor both CRBA benefit and risk questions, about 50% of respondents chose 0 (the ‘correct’ response of ‘average likelihood’), and 50% chose a non-0 response. Respondents’ rationales for their estimates showed that overall only about 40%–44% gave comparative rationales, indicating that they interpreted the CRBA as intended. 68.7% of respondents who gave the ‘correct’ 0 rating gave comparative rationales, whereas only 11.6% of respondents who gave non-0 ratings did so. A similar trend was seen for chances of risk (p<0.001 for both).ConclusionResearch participants may not understand comparative benefit and risk questions as intended; attributions of unrealistic optimism may require additional evidence that the respondents’ estimates are intended to be comparative.
Determinants of Left Ventricular Dysfunction and Remodeling in Patients With Corrected Tetralogy of Fallot
Authors: Andrade Ana Cristina , Jerosch‐Herold Michael , Wegner Philip , Gabbert Dominik Daniel , Voges Inga , Pham Minh , Shah Ravi , Hedderich Jürgen , Kramer Hans‐Heiner , Rickers Carsten 
Published: August 2019

Background
The aim of this study was to identify in asymptomatic patients with repaired tetralogy of Fallot the prevalence and determinants of impaired left‐sided cardiac function and adverse ventricular remodeling and the relation of left ventricular (LV) dysfunction and remodeling with cardiopulmonary exercise capacity.

Methods and Results

In a cross‐sectional study, 103 patients with tetralogy of Fallot (median age, 16.3 years) in New York Heart Association class 1, with surgical repair at a median age of 1.1 years, and 63 age‐matched controls were studied. LV, right ventricular function and geometry, LV myocardial extracellular volume (n=57), and left atrial function were quantified with cardiac magnetic resonance. Peak oxygen consumption was measured by a standardized cardiopulmonary exercise test (n=70). Patients with tetralogy of Fallot had lower LV ejection fraction (
P
=0.001; 49% below age‐adjusted fifth percentile for controls), lower LV mass index (
P
=0.003), lower LV mass/volume ratio (
P
<0.01), and impaired left atrial function. Right ventricular mass/volume ratio was the best predictor for LV systolic dysfunction and for a lower LV mass/volume ratio. Compared with controls, LV extracellular volume was higher (
P
<0.001), particularly in female patients, and associated with subnormal peak oxygen consumption (
P
=0.037). A peak oxygen consumption below the third percentile reference level was more likely with decreasing LV ejection fraction (
P
=0.008), and lower LV mass index (
P
=0.024), but independent of right ventricular ejection fraction.

Conclusions
In New York Heart Association class 1 patients with tetralogy of Fallot, frequent impaired systolic and diastolic LV function, LV adverse remodeling with LV atrophy, a decreased mass/volume ratio, and extracellular matrix expansion suggest cardiomyopathic changes. The best predictor for LV systolic dysfunction was the right ventricular mass/volume ratio. The subnormal peak oxygen consumption indicates that monitoring of LV status may be important for long‐term prognosis.
A Renewed Reading of Hebrew Ostraca from Cave A-2 at Ramat Beit Shemesh (Naḥal Yarmut), Based on Multispectral Imaging
Authors: Mendel-Geberovich Anat , Faigenbaum-Golovin Shira , Shaus Arie , Sober Barak , Cordonsky Michael , Piasetzky Eli , Finkelstein Israel , Milevski Ianir 
Published: August 2019

AbstractThree Hebrew ostraca, found near Khirbet Zanu’ (Ḥorvat Zanoaḥ) and published by Milevski and Naveh in 2005, were re-imaged using a high-end multispectral imaging technique. The re-imaging yielded dozens of changed or added characters and resulted in renewed, larger and improved readings, hereby published. In addition, we interpret the texts of the ostraca and place them in the context of the economy and administration of Judah in the seventh century BCE.
A Prayer for Purification
Authors: van Wolde Ellen 
Published: August 2019

Abstract
This article focuses on the pivotal role of verses 12-14 in Psalm 51. In v. 13 the speaker expresses the fear that due to his transgressions God’s spirit of holiness will be taken away, because God does not tolerate impurity of any kind. For the impurity generated by the transgressions will be projected onto the sanctuary, which in this way will be defiled. Therefore, aligned with רוח קדשך in v. 13 is טהור לב in v. 12: purity is the sine qua non for God’s holy spirit to stay and keep active in the midst of the Israelites. In this view, the impure world of words and deeds is the total from which the pure ones are to be separated. It is not the purity of the heart itself, but the process of purification that is expressed here, so that the pure heart remains, cleared of sins.
Contact between Old Persian and Hebrew? A Rejoinder to A. Wilson-Wright
Authors: Samuel Harald 
Published: August 2019

Abstract
In his recent article “From Persepolis to Jerusalem: A Reevaluation of Old Persian-Hebrew Contact in the Achaemenid Period”, Aren Wilson-Wright reexamines the list of proposed Persian loans in Biblical Hebrew as well as their distribution, specifically in relation to the distinction between Classical and Late Biblical Hebrew. He seeks to demonstrate direct contact between speakers of Old Persian and Hebrew and proposes two further Old Persian calques.
This paper reevaluates Wilson-Wright’s proposals on both methodological and philological levels, and offers a fuller dataset for several phenomena. While allowing the principal distinction between Classical and Late Biblical Hebrew, questions of textual genesis and transmission are combined with sociolinguistic considerations to explore the possible ramifications of the proposed linguistic interaction: What do we know about the use of Old Persian apart from royal inscriptions? What do we know about Iranians, locals and their use of language in the Achaemenid administration? The result is a much more complex picture of multiple linguistic interference with many unknowns.
The Macrostructural Logic of the Alphabetic Poems in the Psalter
Authors: Ho Peter C. W. 
Published: August 2019

AbstractWith the emergence of the canonical approach to the Psalter, individual psalms are no longer studied as standalone compositions, but viewed along a continuum of psalms to provide meaning. While scholars have analysed alphabetic poems and how they add to meaning, the study of such poems has rarely gone beyond the individual psalm. This paper seeks to understand alphabetic poems within the horizon of the Psalter and whether they function together to provide meaning at the macrostructural level. The paper begins with analyses of eight generally accepted alphabetical acrostics in the Psalter. From their characteristics, a total of forty-six alphabetic poems are suggested. It is observed that these poems mark leitmotifs at prominent locations and develop the motif of David across the entire Psalter. The macrostructural logic of alphabetical poems, as a whole, is subservient to the overarching theological thrust of the Psalter.
Philology and Theory: Exodus 12:21-27 as a Case Study
Authors: Gesundheit Shimon 
Published: August 2019

Abstract
Using Exod 12:21-27 as a case study, this paper shows how literary analysis can find itself subordinated to historical-critical theory. It will be argued that this practice is ill advised. An established reading of a text should never be dismissed when it is found to challenge accepted paradigms. It is, rather, the presumed historical and social settings that must be problematized.
Double Tendance: The Photographic Message in the Egyptian Jewish Youth Magazine L’Illustration Juive, 1929–1931
Authors: Guedj David 
Published: August 2019

Abstract
The present article investigates the visual elements of the illustrated youth quarterly L’Illustration Juive, which was published in Alexandria between 1929 and 1931 in French and Hebrew. The analysis sets out to expose the ideologies and worldviews informing the publication’s editorial board, as well as the conscious or unconscious message that the quarterly tried to communicate to its young readership. The article explores more than 300 photographs and reproductions that featured in twelve issues published over the journal’s three years of existence. Analysis of the visual elements in this article shows that the quarterly featured many photographs of holy sites in the Land of Israel, as well as reproductions of artworks that reflected the religious Jewish way of life in the diaspora and Israel, including the Jewish calendar and Jewish life cycle. These works hold the Old Testament as a key book for Judaism, as well as for Jewish nationalism. Clearly evident in the visual elements, as in the overall visual messages of the quarterly, is the harmony struck between Jewish nationality, Zionism, and a religious Jewish cultural—or diasporic—world. It was this harmonious view that editor Rabbi David Prato sought to convey, upholding as he did a religious nationalist Jewish future, which he defined in the newspaper as a double tendance.
Jewish Childhood Transformed: Through the Looking Glass of Art and Visual Representation in Pre- and Post-Revolutionary Russia
Authors: Kotlyar Eugeny 
Published: August 2019

Abstract
The present article studies the thematic ways in which Jewish childhood was represented in Russian Jewish art and visual media from the 1850s to the 1930s. During this period, Russian Jewry was undergoing important transformations. It saw the establishment of a traditional model of religious life, a subsequent process of modernization and acculturation, and finally the education of the “New Jew” as part of post-Revolutionary secular culture, as well as the seeding of extreme forms of radicalization that would develop in the Soviet era. Jewish art and visual media were always a documentary means of representing collective ideals, key among which was the value associated with Jewish children’s future. The images preserved in art, photography, and print show how diligent study for boys and young men was extolled in traditional communities; this resulted in the formation of an intellectual elite that served as a bulwark of religious and spiritual self-consciousness against outside cultural influences. Along with historical-statistical studies and memoirs, these images recreate a psycho-emotional and social background for the traditional model of children’s education. On the one hand, this model perpetuated the lifestyle and values established over the centuries, yet on the other, it sparked charges of anachronism and fanaticism, which intensified the antagonism of Russian society toward its Jewish minority. The same model proved to be extremely influential for the Jewish masses; it came by its iconic visual representation in various “Cheder” compositions and portraits of the “Talmudist Iluy.” Both types of works brought out the value of religious education. Later artistic depictions demonstrated that upon passing through the grinder of the Soviet atheist system, this model inspired the zeal that Jews had for secular education and the prospect of their children’s being granted equal opportunity, resulting in the loss of their ethno-cultural identity in the new Soviet reality.
Frequency-specific oscillations synchronization in primary angle-closure glaucoma
Authors: Jiang Fei , Ye Yin-Quan , Zuo Jin-Min , Huang Xin , Yu Chen , Zeng Xian-Jun 
Published: August 2019

Background Previous neuroimaging studies demonstrated that patients with primary angle-closure glaucoma were accompanied by abnormal neuronal activity. Purpose To investigate frequency-dependent local oscillations synchronization in primary angle-closure glaucoma using the regional homogeneity method. Material and Methods In total, 37 individuals with primary angle-closure glaucoma (20 men, 17 women) and 37 normal-sighted controls (20 men, 17 women) closely matched in age, sex, and education underwent resting-state MRI scans. We compared the different regional homogeneity values in full band (0.01–0.08 Hz) and two different frequency bands (slow-4: 0.027–0.073 Hz and slow-5: 0.010–0.027 Hz) between two groups. Results Compared to the normal-sighted group, the primary angle-closure glaucoma group showed decreased regional homogeneity values in the left calcarine and left postcentral in full band. The primary angle-closure glaucoma group showed increased regional homogeneity values in the bilateral superior medial frontal lobe in the slow-4 band. The primary angle-closure glaucoma group exhibited decreased regional homogeneity values in the right calcarine in the slow-5 band. Specifically, we found that the regional homogeneity values in the right superior frontal lobe were greater in the slow-4 than in the slow-5 band, whereas regional homogeneity in the left calcarine, right pallidum, left inferior occipital gyrus, left superior occipital gyrus, left postcentral/angular gyrus, left paracentral lobule, left superior parietal gyrus, and right precuneus gyrus were greater in the slow-5 than in the slow-4 band. Conclusion Primary angle-closure glaucoma groups showed abnormal regional homogeneity in visual network (calcarine) and default mode network (superior medial frontal lobe) at two frequency bands. Moreover, the regional homogeneity signals in slow-5 band showed closely related to the severity of individuals with primary angle-closure glaucoma.
Effect of hypothermia on haemostasis and bleeding risk: a narrative review
Authors: Kander Thomas , Schött Ulf 
Published: August 2019

It must be remembered that clinically important haemostasis occurs in vivo and not in a tube, and that variables such as the number of bleeding events and bleeding volume are more robust measures of bleeding risk than the results of analyses. In this narrative review, we highlight trauma, surgery, and mild induced hypothermia as three clinically important situations in which the effects of hypothermia on haemostasis are important. In observational studies of trauma, hypothermia (body temperature <35°C) has demonstrated an association with mortality and morbidity, perhaps owing to its effect on haemostatic functions. Randomised trials have shown that hypothermia causes increased bleeding during surgery. Although causality between hypothermia and bleeding risk has not been well established, there is a clear association between hypothermia and negative outcomes in connection with trauma, surgery, and accidental hypothermia; thus, it is crucial to rewarm patients in these clinical situations without delay. Mild induced hypothermia to ≥33°C for 24 hours does not seem to be associated with either decreased total haemostasis or increased bleeding risk.
Flexible Fixation Technique for Lisfranc Injuries
Authors: Delman Connor , Patel Midhat , Campbell Mark , Kreulen Christopher , Giza Eric 
Published: August 2019

Injuries to the Lisfranc complex range from purely ligamentous disruptions to fracture-dislocations of the tarsometatarsal joint. Treatment options include closed/open reduction with percutaneous pinning, open reduction and internal fixation (ORIF), and primary arthrodesis. We present a ligament reinforcement technique utilizing a flexible fixation device for the treatment of ligamentous Lisfranc injuries. Level of Evidence: Level V, expert opinion.
Supporting self-management education for arthritis: Evidence from the Arthritis Conditions and Health Effects Survey on the influential role of health care providers
Authors: Murphy Louise B , Theis Kristina A , Brady Teresa J , Sacks Jeffrey J 
Published: August 2019

Objective Self-management education programs are recommended for many chronic conditions. We studied which adults with arthritis received a health care provider’s recommendation to take a self-management education class and who attended. Methods We analyzed data from a 2005--2006 national telephone survey of US adults with arthritis ≥45 years ( n = 1793). We used multivariable-adjusted prevalence ratios (PR) from logistic regression models to estimate associations with: (1) receiving a health care provider recommendation to take a self-management education class; and (2) attending a self-management education class. Results Among all adults with arthritis: 9.9% received a health care provider recommendation to take an self-management education class; 9.7% attended a self-management education class. Of those receiving a recommendation, 52.0% attended a self-management education class. The strongest association with self-management education class attendance was an health care provider recommendation to take one (PR = 8.9; 95% CI = 6.6–12.1). Conclusions For adults with arthritis, a health care provider recommendation to take a self-management education class was strongly associated with self-management education class attendance. Approximately 50% of adults with arthritis have ≥1 other chronic conditions; by recommending self-management education program attendance, health care providers may activate patients’ self-management behaviors. If generalizable to other chronic conditions, this health care provider recommendation could be a key influencer in improving outcomes for a range of chronic conditions and patients’ quality of life.