bluuebunny/crossref_metadata_2025_split huggingface dataset:
Flying asset
Authors: Martinetti Alberto , Schakel Erik Jan , van Dongen Leo A.M. 
Published: March 2018

Purpose
The purpose of this paper is to create a framework to provide a scalable maintenance program for unmanned aircraft systems (UAS) in order to choose the most suitable and feasible maintenance strategy in terms of reliability.

Design/methodology/approach
The paper opted for a reliability-centered maintenance-based approach to develop the framework using a UAS as the starting point of the research. A linear and user-friendly design of the methodology based on a Boolean flowchart was chosen in order to lead the analyst through the process avoiding as much as possible subjectivity decision-making issues. Finally, the framework was, on the component level, performed by a UAS company gathering feedback on its applicability.

Findings
An agile and structured decision-making framework for developing scalable maintenance program of UAS is provided. The proposed solution gives the opportunity to tailor the maintenance strategy to the technical characteristics, considering not only the single component but also situations and conditions in which the machine will operate.

Research limitations/implications
Because of the chosen research approach, the framework is potentially applicable to every UAS. A first trial of the method was run on a multirotor vehicle equipped with eight electric brushless motors. Further studies focused on different UAS will be mandatory in order to obtain comparable and robust findings and a reliable approach.

Practical implications
This study offers a different scheme to elaborate a specific maintenance solution related to the characteristics of the system. It strives to remedy the drawbacks of the traditional approach for a manned aircraft not completely suitable for systems with such different functions, features and tasks. The authors believe that the method presented in this paper will provide a new selection tool for choosing maintenance actions based on the features of the UAS.

Originality/value
This paper provides a new and usable solution to include the maintenance actions in the management of pioneering products. In spite of the maintenance program representing an essential aspect to provide reliable assets, frameworks to create programs and to help manufacturers and users are still difficult to find or to apply to different UAS. This gap enhances the misunderstanding that the maintenance is not required or essential for the unmanned aircrafts management.
Trade credit in times of crisis: evidence from European SMEs
Authors: Bussoli Candida , Marino Francesca 
Published: March 2018

Purpose
The purpose of this paper is to investigate the use of trade credit in a sample of small and medium enterprises in Europe, before and after the outbreak of the subprime financial crisis and the sovereign debt crisis (2006-2013). This study aims to verify whether trade credit is an alternative source of funding compared to other sources of financing. In addition, it tests whether firms that grant extended payment terms to their customers demand delayed accounts payable terms from their suppliers.

Design/methodology/approach
The empirical analysis is conducted on a sample of European SMEs that were observed over the period immediately before and after the outbreak of the subprime crisis (2008) and the sovereign debt crisis (2010-2011). A panel data analysis is conducted using the generalized method of moment.

Findings
The results suggest that SMEs with a high probability of insolvency use trade credit more extensively. Distressed and weaker SMEs are less able to match accounts receivable to accounts payable. Finally, the evidence suggests that during the financial crises, the substitution hypothesis is weakened and liquidity shocks are propagated through trade credit channels.

Originality/value
This study contributes to the extant literature as very few studies have analyzed intercompany financing for European SMEs during periods of financial crisis. The results suggest that supporting trade credit channels, through timely injections of liquidity to companies, could reduce the impact of both financial and intercompany credit crunch on SMEs.
Imagining with the body in analytical psychology. Movement as active imagination: an interdisciplinary perspective from philosophy and neuroscience
Authors: Deligiannis Ana 
Published: March 2018

AbstractThis article explores how the body and imagination operate as pathways of knowledge through the use of Movement as Active Imagination in clinical practice. This method activates the transcendent function, thus encouraging new therapeutic responses. A philosophical perspective (Spinoza, Nietzsche, Merleau‐Ponty) and some concepts from neuroscience (embodied cognition, somatic markers, image schema, mirror neurons, neuronal plasticity) will accompany us throughout this work, illustrated with a clinical vignette. Three levels of integration: 1) body, 2) body‐emotion, 3) body‐emotion‐imagination are proposed: these mark a progressive sense of articulation and complexity. Finally the relation between creativity and neuronal plasticity will be considered.
Overexpression of long non‐coding RNA KCNQ1OT1 is related to good prognosis via inhibiting cell proliferation in non‐small cell lung cancer
Authors: Sun Xiao , Xin Yanlu , Wang Maolong , Li Shicheng , Miao Shuncheng , Xuan Yunpeng , Wang Yuanyong , Lu Tong , Liu Jia , Jiao Wenjie 
Published: March 2018

BackgroundLung cancer (LC) is the most common malignancy in the world. Many long non‐coding RNAs (lncRNAs) have been reported to be associated with LC; however, the function of KCNQ1OT1 in LC requires exploration.MethodsWe conducted in silico analysis with data from The Cancer Genome Atlas to investigate the association between KCNQ1OT1 and LC. A Kaplan–Meier plotter was used to analyze the function of KCNQ1OT1 on LC patient prognosis. Quantitative reverse transcription‐PCR (qRT‐PCR) was performed to confirm previous results. An A549 lung cancer cell was transfected with pcDNA‐KCNQ1OT1, and methyl thiazolyl tetrazolium assay was performed to investigate the function of KCNQ1OT1 on cell proliferation. in vivo assay was performed with nude mice.ResultsBioinformatics analysis and qRT‐PCR indicated that KCNQ1OT1 expression was higher in stage I LC patients (P < 0.01), and survival analysis showed that high expression of KCNQ1OT1 in LC patients was associated with better prognosis (P < 0.05). qRT‐PCR showed a negative correlation between KCNQ1OT1 and Ki67 expression and tumor size (P < 0.01), which indicated that KCNQ1OT1 is associated with tumor growth in LC. There was no significant correlation between KCNQ1OT1 level and lymph node metastasis (P > 0.05). KCNQ1OT1 overexpression significantly inhibited cell proliferation and tumor growth in vitro and in vivo (P < 0.05).ConclusionOur preliminary data showed that KCNQ1OT1 is overexpressed in early stage LC and is correlated with better prognosis in LC patients, possibly by suppressing cell proliferation.
Trends in the incidence rate of lung cancer by histological type and gender in Sichuan, China, 1995–2015: A single‐center retrospective study
Authors: Zhang Xiaoxuan , Wu Li , Xu Yong , Zhang Benxia , Wu Xueqian , Wang Yongsheng , Pang Zongguo 
Published: March 2018

BackgroundIn recent years, lung cancer incidence has been increasing; however the impact of different histological types of lung cancer is not yet clear.MethodsTrends in the lung cancer incidence rate by histological type were examined based on data of 36 658 primary lung cancer patients from West China Hospital between 1995 and 2015.ResultsThe most common histological type of lung cancer in our hospital was adenocarcinoma (ADC) in both genders, followed by squamous cell carcinoma (SQCC), and small cell carcinoma (SCLC), which is consistent with general worldwide trends. The proportion of young patients with SCLC showed a downward trend. In the overall population with lung cancer, the number of elderly patients with lung cancer increased significantly, while the proportion of elderly patients increased gradually. The mean age at diagnosis also increased. The number of women with ADC increased sharply in recent years, especially in young patients, and the incidence rate in women is now greater than in men.ConclusionSignificant increases in the number of patients with ADC and the rate of lung cancer in women over recent years were observed, indicating that research on the pathogenesis of disease in these patients is urgent.
Pitching research: ‘qualitative cousins’ and the ‘extended family’
Authors: Faff Robert 
Published: March 2018

AbstractThis study has two related goals – one very specific and one more general. The specific goal is to constructively engage with Lodhia (2017) on the issue of whether and to what extent ‘qualitative cousins’ are well served by Faff's (2015) original pitching research (PR) template. Using this ‘cousins’ focus as a primer, the more general goal is to update the agenda created by Faff (2015) and in so doing, explore the ‘extended family’ of PR work/resources now available.
Water and cattle shape habitat selection by wild herbivores at the edge of a protected area
Authors: Valls‐Fox H. , Chamaillé‐Jammes S. , de Garine‐Wichatitsky M. , Perrotton A. , Courbin N. , Miguel E. , Guerbois C. , Caron A. , Loveridge A. , Stapelkamp B. , Muzamba M. , Fritz H. 
Published: March 2018

AbstractUnderstanding the spatiotemporal dynamics of human‐wildlife interfaces is important for the sustainable management of protected areas and wildlife conservation. We investigated the drivers of domestic and wild herbivore habitat selection at the edge of an unfenced protected area adjacent to Hwange National Park, Zimbabwe. We used GPS data to quantify the movement patterns of elephant bulls, buffalo and cattle at multiple scales and according to seasonal changes of surface water availability. Cattle, elephant and buffalo prefer open grassland habitats found close to water but elephant and buffalo avoid cattle differently. During the rainy season, cattle enter the protected area daily; buffalo avoid cattle completely at the home range scale, whereas elephant bulls avoid cattle at finer scales by favoring temporal niche shift. Elephant bulls avoid direct encounters with cattle (or people) during the day but come closer to the boundary and to water at night when cattle are kept in enclosures close to the homesteads. During the dry season, when cattle range further into the protected area in search of forage, buffalo and cattle spatial overlap increases as water dependence takes precedence over avoidance. Elephant bulls range closer to the boundary at night and increase the number of excursions into the Communal Area. Cattle herding creates a buffer zone between wildlife areas and human settlements because wild herbivores strongly avoid livestock and people. However, avoidance only lasts as long as resources are abundant. Our study suggests that long‐term planning of both artificial water provisioning and traditional cattle herding practices could help maintaining spatial segregation and thus mitigate conservation conflicts such as pathogen transmission, crop raiding or livestock depredation.
Pharmacogenetics of Dopamine β‐Hydroxylase in cocaine dependence therapy with doxazosin
Authors: Zhang Xuefeng , Nielsen David A. , Domingo Coreen B. , Shorter Daryl I. , Nielsen Ellen M. , Kosten Thomas R. 
Published: March 2018

AbstractThe α1‐adrenergic antagonist, doxazosin, has improved cocaine use disorder (CUD) presumably by blocking norepinephrine (NE) stimulation and reward from cocaine‐induced NE increases. If the NE levels for release were lower, then doxazosin might more readily block this NE stimulation and be more effective. The NE available for release can be lower through a genetic polymorphism in dopamine β‐hydroxylase (DBH) (C‐1021T, rs1611115), which reduces DβH's conversion of dopamine to NE. We hypothesize that doxazosin would be more effective in CUD patients who have these genetically lower DβH levels. This 12‐week, double‐blind, randomized, placebo‐controlled trial included 76 CUD patients: 49 with higher DβH levels from the DBH CC genotype and 27 with lower DβH levels from T‐allele carriers (CT or TT). Patients were randomized to doxazosin (8 mg/day, N = 47) or placebo (N = 29) and followed with thrice weekly urine toxicology and once weekly cognitive behavioral psychotherapy. Cocaine use was reduced at a higher rate among patients in the doxazosin than in the placebo arm. We found significantly lower cocaine use rates among patients carrying the T‐allele (CT/TT) than the CC genotype. The percentage of cocaine positive urines was reduced by 41 percent from baseline in the CT/TT group with low DβH and NE levels, as compared with no net reduction in the CC genotype group with normal DβH and NE levels. The DBH polymorphism appears play an important role in CUD patients' response to doxazosin treatment, supporting a pharmacogenetic association and potential application for personalized medicine.
Examining clinicians’ perceptions of head and neck cancer (HNC) information
Authors: Jabbour Joe , Wykes James , Milross Chris , Sundaresan Puma , Ebrahimi Ardalan , Shepherd Heather L. , Dhillon Haryana M. , Clark Jonathan R. 
Published: March 2018

AbstractBackgroundProviding appropriate educational resources to patients with head and neck cancer (HNC) is important but challenging. The aim of this study was to determine Australian clinicians’ perceptions of currently used HNC information resources.MethodsA purpose‐designed questionnaire was disseminated electronically to clinician members of the Australian and New Zealand Head and Neck Cancer Society (ANZHNCS) and The Australian Society of Otolaryngology Head and Neck Surgery (ASOHNS).ResultsOf the 648 clinicians invited, 112 responded to the survey (17.3% response rate). Overall, 85% utilized written information as their primary mode of patient education and 49% received information on treatment details. Areas for improvement include information provision, pain management, emerging risk factors, survivorship and side effects. The majority (66%) of clinicians had a preference for internet patient education materials.ConclusionsClinicians predominantly utilized written HNC information rather than multimedia or interactive resources. However, they expressed the desire to be able to deliver HNC information resources via an internet‐based platform covering the psychosocial effects of treatment.
Readmissions for surgical site infections following caesarean section
Authors: El‐Achi Vanessa , Wan King Man , Brown James , Marshall Drew , McGee Therese 
Published: March 2018

This retrospective study was conducted to identify the incidence and characteristics associated with readmissions for surgical site infections following caesarean section in a tertiary hospital from 2012 to 2015. Of 6334 patients who underwent caesarean section, 165 (2.6%) were readmitted, most commonly for surgical site infection (25.5%, n = 42). Thirty‐seven of these patients (88%) had an emergency caesarean compared to five (12%) following an elective caesarean section. Of the women with surgical site infections, 69% were overweight and 14% had diabetes. Emergency caesarean sections were responsible for the majority of readmissions, particularly in women with co‐morbidities that predisposed them to infection.
EAA clinical guideline on management of bone health in the andrological outpatient clinic
Authors: Rochira V. , Antonio L. , Vanderschueren D. 
Published: March 2018

SummaryMale osteoporosis is now a well‐recognized medical disorder with established clinical guidelines for both diagnosis and management. Prevention as well as management of osteoporosis in men consulting the andrological outpatient clinic because of low testosterone, however, is not well established. This gap of knowledge is—at least partly—explained by the controversy with respect to the threshold of testosterone needed for skeletal maintenance. However, testosterone deficiency may be clearly associated with bone loss as well as frailty in men. If anything, andrologists should therefore be aware of the potential silent presence of osteoporosis in men with confirmed hypogonadism. Therefore, the management of patients with potential hypogonadism should include a complete bone health assessment, besides clinical and biochemical evaluation of gonadal status. Such bone health assessment should include specific items in medical history and physical examination related to fracture risk. Furthermore, dual‐energy absorptiometry is indicated to evaluate fracture risk in men with confirmed clinical hypogonadism. Regarding treatment, besides general measures to prevent or manage male osteoporosis testosterone replacement can be initiated (as described in guidelines for hypogonadism), but data on its efficacy in preventing fractures are lacking. Thus, additional anti‐osteoporotic may be needed, especially in men with very low testosterone who are at high risk of bone loss and/or in men not able to receive testosterone replacement.
Optical coherence tomography angiography in patients with retinitis pigmentosa who have normal visual acuity
Authors: Takagi Seiji , Hirami Yasuhiko , Takahashi Masayo , Fujihara Masashi , Mandai Michiko , Miyakoshi Chisato , Tomita Goji , Kurimoto Yasuo 
Published: March 2018

AbstractPurposeTo investigate flow area changes measured using optical coherence tomography angiography (OCTA; RTVue XR Avanti®) in patients with retinitis pigmentosa (RP) with preserved visual acuity (VA).MethodsThis was an age‐ and refraction‐matched case–control study. Consecutive patients with a best‐corrected visual acuity (BCVA) of ≥20/20 and normal subjects were recruited. Fifty eyes (32 patients) and 22 eyes (12 controls) were included. The flow area and foveal avascular zone (FAZ) were measured in both superficial and deep layers within a 3 × 3 mm central area of the fovea. Association between OCTA parameters and the length of the inner segment ellipsoid (ISe) and external limiting membrane (ELM), the area without abnormal fluorescence in fundus autofluorescence (normal FAF area ratio) and the area of I‐2e of the Goldmann perimeter were analysed using mixed‐effects regression analysis.ResultsFoveal avascular zones were significantly smaller in patients with RP than in controls in superficial (p = 0.004) but not in deep layers (p = 0.25). The flow area in superficial (p = 0.007) and deep layers (p = 0.004) was significantly smaller in patients with RP than in controls. In patients with RP, flow areas in the superficial layers, but not in the deep layers, were significantly associated with the lengths of ISe (p = 0.001) and ELM (p = 0.002) and the I‐2e area (p = 0.036), but not with the normal FAF area ratio (p = 0.399).ConclusionOptical coherence tomography angiography (OCTA)‐measured flow area in superficial layers gradually reduced with RP progression and may be a useful parameter of RP pathogenesis.
Wisdom of the social versus non‐social crowd in face identification
Authors: Jeckeln Géraldine , Hahn Carina A. , Noyes Eilidh , Cavazos Jacqueline G. , O'Toole Alice J. 
Published: March 2018

Face identification is more accurate when people collaborate in social dyads than when they work alone (Dowsett & Burton, 2015, Br. J. Psychol., 106, 433). Identification accuracy is also increased when the responses of two people are averaged for each item to create a ‘non‐social’ dyad (White, Burton, Kemp, & Jenkins, 2013, Appl. Cogn. Psychol., 27, 769; White et al., 2015, Proc. R. Soc. B Biol. Sci., 282, 20151292). Does social collaboration add to the benefits of response averaging for face identification? We compared individuals, social dyads, and non‐social dyads on an unfamiliar face identity‐matching test. We also simulated non‐social collaborations for larger groups of people. Individuals and social dyads judged whether face image pairs depicted the same‐ or different identities, responding on a 5‐point certainty scale. Non‐social dyads were constructed by averaging the responses of paired individuals. Both social and non‐social dyads were more accurate than individuals. There was no advantage for social over non‐social dyads. For larger non‐social groups, performance peaked at near perfection with a crowd size of eight participants. We tested three computational models of social collaboration and found that social dyad performance was predicted by the decision of the more accurate partner. We conclude that social interaction does not bolster accuracy for unfamiliar face identity matching in dyads beyond what can be achieved by averaging judgements.
Impact of hospital volume and surgeon volume on robot‐assisted partial nephrectomy outcomes: a multicentre study
Authors: Peyronnet Benoît , Tondut Lauranne , Bernhard Jean‐Christophe , Vaessen Christophe , Doumerc Nicolas , Sebe Philippe , Pradere Benjamin , Guillonneau Bertrand , Khene Zine‐Eddine , Nouhaud Francois‐Xavier , Brichart Nicolas , Seisen Thomas , Alimi Quentin , Beauval Jean‐Baptiste , Mathieu Romain , Rammal Adham , de la Taille Alexandre , Baumert Herve , Droupy Stéphane , Bruyere Franck , Rouprêt Morgan , Mejean Arnaud , Bensalah Karim ,   The members of the French Committee of Urologic Oncology (CCAFU)
Published: March 2018

ObjectiveTo assess the impact of hospital volume (HV) and surgeon volume (SV) on perioperative outcomes of robot‐assisted partial nephrectomy (RAPN).Patients and MethodsAll consecutive patients who underwent a RAPN from 2009 to 2015, at 11 institutions, were included in a retrospective study. To evaluate the impact of HV, we divided RAPN into four quartiles according to the caseload per year: low HV (<20/year), moderate HV (20–44/year), high HV (45–70/year), and very high HV (>70/year). The SV was also divided into four quartiles: low SV (<7/year), moderate SV (7–14/year), high SV (15–30/year), and very high SV (>30/year). The primary endpoint was the Trifecta defined as the following combination: no complications, warm ischaemia time (WIT) <25 min, and negative surgical margins.ResultsIn total, 1 222 RAPN were included. The mean (sd) caseload per hospital per year was 44.9 (26.7) RAPNs and the mean (sd) caseload per surgeon per year was 19.2 (14.9) RAPNs. The Trifecta achievement rate increased significantly with SV (69.9% vs 72.8% vs 73% vs 86.1%; P < 0.001) and HV (60.3% vs 72.3% vs 86.2% vs 82.4%; P < 0.001). The positive surgical margins (PSM) rate (P = 0.02), length of hospital stay (LOS; P < 0.001), WIT (P < 0.001), and operative time (P < 0.001), all decreased significantly with increasing SV. The PSM rate (P = 0.02), LOS (P < 0.001), WIT (P < 0.001), operative time (P < 0.001), and major complications rate (P = 0.01), all decreased significantly with increasing HV. In multivariate analysis adjusting for HV and SV (model 3), HV remained the main predictive factor of Trifecta achievement (odds ratio [OR] 3.70 for very high vs low HV; P < 0.001), whereas SV was not associated with Trifecta achievement (OR 1.58 for very high vs low SV; P = 0.34).ConclusionIn this multicentre study HV and SV both greatly influenced RAPN perioperative outcomes, but HV appeared to have a greater impact than SV.