bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Novel Naphthotriazolyl-4-oxoquinoline Derivative that Selectively Controls Breast Cancer Cells Survival Through the Induction of Apoptosis
Authors: Branco Jessica R. , Oliveira Vanessa G. , Esteves Amanda M. , Chipoline Ingrid C. , Lima Miriam F.O. , Boechat Fernanda C.S. , da Silva Fernando C. , Ferreira Vítor F. , Sola-Penna Mauro , de Souza Maria C.B.V. , Zancan Patricia 
Published: August 2018

Background:
Breast cancer is a major cause of death among women worldwide. Treatment
for breast cancer involves the surgical removal of cancer tissue, followed by chemotherapy. Although
the treatment is efficient, especially when the cancer is detected early, recurrence is common and is often
resistant to the previous treatment. Therefore, a constant search for efficient and novel drugs for the
treatment of breast cancer is mandatory. Recently, triazole derivatives have shown promising effects
against different types of cancer, revealing these molecules as putative anticancer drugs.

Experimental:
We have synthesized a series of naphthotriazolyl-4-oxoquinoline derivatives and tested
their activity against a human breast cancer cell line. Among the compounds tested, we identified a
molecule that killed the human breast cancer cell line MCF-7 with minimal effects on its noncancer
counterpart, MCF10A. This effect was seen after 24 hours of treatment and persisted for additional 24
hours after treatment withdrawal. After 1 hour of treatment, the compound, here named 12c, promoted a
decrease in cell glucose consumption and lactate production. Moreover, the cells treated with 12c for 1
hour showed diminished intracellular ATP levels with unaltered mitochondrial potential and increased
reactive oxygen species production. Additionally, apoptosis was triggered after treatment with the drug
for 1 hour. All of these effects are only observed with MCF-7 cells, and not MCF10A. These data show
that 12c has selective activity against breast cancer cells and is a potential candidate for a novel anticancer
drug.

Results and Conclusion:
The naphthotriazolyl-4-oxoquinoline derivatives were obtained in good to
moderate yields, and one of them, 12c, exhibited strong and selective antitumor properties. The antitumor
mechanism involves inhibition of glycolysis, diminished intracellular ATP levels, induction of ROS
production and triggering of apoptosis. These effects are all selective for cancer cells, since noncancer
cells are unaffected, and these effects can only be attributed to the whole molecule, as different pharmacophoric
groups did not reproduce these effects.
Efficacy and Safety of Targeting Androgen Receptor in Advanced Breast Cancer: A Systematic Review
Authors: Kassem Loay , Shohdy Kyrillus S. , Makady Nafie F. , Salem Dalal S. , Ebrahim Nadia , Eldaly Mostafa 
Published: August 2018

Background::Androgen receptor (AR) upstreams complex signaling pathways that regulate cell proliferation and contribute to breast tumorignensis. Several clinical trials were initiated to investigate the clinical relevance of targeting AR especially in hormone-receptor-negative breast cancer.Methods::The search was performed in PubMed and the meeting libraries of ASCO, ESMO, SABCS, ImpakT congresses from January 2005 to July 2017. The following key words were used: Breast cancer, Androgen receptor, androgen agonist/antagonist, Flutamide, Abiraterone, Bicalutamide, Enzalutamide, Enobosarm, selective androgen receptor modulator.Results::Screening of title/abstracts yielded a total of 20 relevant results. Of those, twelve studies were found eligible: eleven clinical trials along with one case report. Response rates ranged from 0 to 12% while clinical benefit rates reached up to 35% in 2 studies (with enzalutamide and enobosarm). Progression-free survival ranged from 2.8 to 4.5 months. The most widely used cutoff for AR expression was 10%. High expression of AR was associated with more clinical benefit. Regarding safety, anti-androgens were generally well tolerated with hot flushes, elevated transaminases and fatigue being the most commonly reported across all agents.Conclusion::Androgen receptor pathway targeting in advanced breast cancer remains a valid option with reasonable clinical benefit in non-selected patients. Future studies are needed to define an AR addicted cohort with better responses and outcome.
Phytochemical Investigation, Acute Toxicity, Central Analgesic and Antioxidant Activities of Extracts and Essential Oil of Cotula cinerea Del (Asteraceae)
Authors: Guaouguaou Fatima E. , Bebaha Mohamed A.A. , Taghzouti Khalid , Es-Safi Nour E. 
Published: August 2018

Background:Cotula cinerea belongs to the Asteraceae family and grows in desert areas such as Moroccan Sahara. The use of this plant in Moroccan traditional medicine prompted us to investigate its chemical composition, its acute oral toxicity, its analgesic and antioxidative activities.Methods:Extraction was conducted by steam distillation for essential oil and by maceration using solvents (hexane, ethyl acetate, n-butanol) for other non-volatile compounds. Quantitative analysis of total polyphenols, procyanidins and flavonoids was conducted through spectrophotometric assays. Qualitative phytochemical composition of the essential oil was investigated by GC/MS analysis. Acute oral toxicity was tested at a dose of 2000 mg/kg in mice. Central analgesic effect was assessed in rat using tail flick and hot plate models and the obtained results were compared to morphine. Antioxidant activity of the essential oil and the obtained extracts was evaluated through 2,2-diphenyl-1- picrylhydrazyl (DPPH°) and 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) (ABTS) assays and the obtained results were compared to TROLOX.Results:The obtained results showed that the studied extracts contained significant amounts of total polyphenols, flavonoids and condensed tannins. The phytochemical composition of the essential oil was predominated by thujone, eucalyptol and santolinatriene. The results of the acute oral toxicity showed that the tested essential oil and extracts were not toxic even at the highest dose of 2000 mg/kg. Experiments on analgesic activity showed that the administered extracts have a central analgesic effect. The highest effect was observed with the n-butanol and ethyl acetate extracts for both tail-flick and hot plate tests. The antioxidant activity of the explored extracts showed higher scavenging activities of the studied samples compared to TROLOX.Conclusion:Our results indicate thus that C. cinerea could be considered as a source of various secondary metabolites including terpenoids and polyphenols. Exploration of its biological activities showed that the plant essential oil and extracts possessed antioxidant and analgesic effects. Based on the results of this study, it is likely that extracts of C. cinerea could open perspectives for its use for pain relief.
Estado serológico para IBR, DVB, Leucosis, Leptospira y Neospora caninum en hembras bovinas del Departamento de Santander, Colombia.
Authors: Vargas-Niño Adriana , Vargas R Jorge , Parra-Martin John Armando , Vásquez R María Cristina , Góngora O Agustín , Mogollón-Waltero Edgar M 
Published: August 2018

Objetivo. Conocer el estado serológico de hembras bovinas a IBR, DVB, leucosis, leptospira y Neospora caninum en el departamento de Santander, Colombia. Materiales y métodos. Se realizó un muestreo por conveniencia en 460 fincas ganaderas de 23 municipios de Santander (Colombia), los sueros colectados fueron analizados mediante diferentes kits comerciales de ELISA siguiendo las instrucciones del fabricante. Resultados. En todas las enfermedades estudiadas se encontraron animales seroreactores, correspondiendo la prevalencia general a Leucosis 21.8%, Leptospira 26.1%, DVB 29.7%, IBR 48.2% y Neospora 63 %. Conclusiones. En el departamento de Santander las enfermedades analizadas se encuentran en la población bovina con prevalencias que fluctúan entre medio a alto, lo cual requiere medidas de control oficial.
¿Las Escuelas de Medicina se deben ocupar en las competencias emocionales de sus estudiantes?
Authors: Esperón Hernández Ramón Ignacio 
Published: August 2018

¿Quiénes somos?, ¿A dónde vamos? A lo largo de los años se ha puesto especial atención en conocer la relación entre la mente y el cuerpo, la razón y el corazón; de tal modo que el pensar y sentir, influye en las decisiones que tomamos como seres humanos, por lo que se ha vuelto el punto central de una discusión inacabada.
Un MOOC, muchos MOOC: diseño multinivel en cursos masivos del área de la salud
Authors: Vadillo Guadalupe , Bucio Jackeline 
Published: August 2018

Los cursos masivos abiertos en línea (MOOC) han tenido un desarrollo vertiginoso en muy pocos años y son causa de polémica y discusión sobre su efectividad. Por su potencial como innovación en la formación de interesados y profesionales en el área de la salud, en este artículo se revisan aspectos, como el diseño multinivel y el modelo invertido para potenciar el impacto de este tipo de cursos.
Docencia en forma de investigación como acción educativa
Authors: Pinto Sofia 
Published: August 2018

Respecto al artículo “Percepción de los académicos del rol docente del médico”, creemos que es una exploración valiosa que nos permite conocer, en su contexto, la falta de valoración de la actividad docente. Al igual que los autores se coincide en la necesidad de implementar estrategias educativas que permitan el desenvolvimiento académico apropiado con miras al reconocimiento docente.
No es aceptación, es sembrar la semilla para entender mejor una tensión educativa. Réplica
Authors: Troncoso Pantoja Claudia 
Published: August 2018

Complementando a los comentarios presentados por investigadores cualitativos en educación en salud y en especial, lo mencionado por Margarita Varela y Tania Vives, sobre la aceptación de este enfoque metodológico a través de la reflexión de sus aportes y elementos que la componen, quisiera agregar que una de las limitaciones para su aceptación, se presenta en el momento de reconocer los resultados obtenidos para difusión académica.
Incorporación de la anatomía comparada a estudios de introducción a la medicina
Authors: Moscoso Quispe Maryory Regina , Olivares-Huaman Renzo M. , Oscco-Zambrano Rodrigo F. 
Published: August 2018

Como estudiantes de medicina humana que estamos en proceso de formación-aprendizaje, nos pareció muy relevante conocer aspectos históricos acerca de anatomía y su evolución; esto nos llevó a realizar búsquedas bibliográficas que nos permitió discernir y pulir nuestros hábitos de investigación.
Peningkatan Hasil Belajar dengan Pendekatan Saintifik Menggunakan Blackberry Messenger dan Metode Jigsaw
Authors: Jaenur Jaenur 
Published: August 2018

This classroom action research is aimed to improve student learning outcomes using a scientific approach with the blackberry messergers and the jigsaw method. The application of scientific approaches, media BBM and methods Jigsaw is one of the innovative learning implementation is expected to improve student learning outcomes. Based on the results of the first cycle of the classroom action research showed that: the average attitude score assesment is 76.9, the percentage of mastery of learning outcomes is 61 %. The average score assessment skills (psychomotor) , project, and portfolio is 77.9, and the percentage of mastery of learning outcomes is 69%. The average of cognitive score (cognitive) on the written test or assignment is 78.0, and the percentage of mastery of learning outcomes is 69%.In the second cycle showed an increase, the average attitude score assesment (attitude) of XI TIPTL 2 is 81.4, the percentage of mastery of learning outcomes is 89%. The average score assessment skills (psychomotor), project, and portfolio is 82, and the percentage of mastery of learning outcomes is 97%. The average of cognitive score (cognitive) on the written test or assignment is 84.2, and the percentage of mastery of learning outcomes is 97%.
Pembelajaran Matematika Berbasis Masalah dengan Strategi Inkuiri Terbimbing dan Inkuiri Bebas Termodifikasi Ditinjau dari Kemampuan Awal Siswa MTs
Authors: Cahyani Eko Diah 
Published: August 2018

The purposes of this study are (1) to test the effect difference of problem based learning strategies guided inquiry and modified free inquiry on student learning outcomes, to (2) test the effect difference early ability categories of high, medium and low student to student learning outcomes, and (3) to test the interaction between early ability category strategy with high, medium and low student to student learning outcomes. This type of research is quantitative with quasi experiment Desain. The population are all students of class VII MTs Ta'mirul Islam Surakarta. The research sample two classes. The sampling technique is cluster random sampling by lottery. Data collection techniques used cognitive testing and documentation. Data were analyzed using analysis of variance of two different cell. The results of the study with α = 5%. The results are (1) there are differences in the effect of problem-based learning strategies guided inquiry and modified free inquiry on student learning outcomes, (2) there are differences in the effect of the initial capabilities categories of high, medium and low student to student learning outcomes, and (3) there is no interaction between early ability category strategy with high, medium and low student to student learning outcomes
Faktor Stratejik Hasil Belajar Matematika Siswa di Sekolah Menegah Pertama
Authors: Sutama S. , Janah Nugraheni Nur , Novitasari Meggy 
Published: August 2018

Tujuan penelitian ini adalah menguji kontribusi penampilan guru dalam pembelajaran, motivasi, dan fasilitas terhadap hasil belajar matematika dengan mediasi kedisiplinan belajar. Jenis penelitian ini adalah kuantitatif korelasional kausal. Populasi penelitian sejumlah 190 siswa kelas VII Sekolah Menengah Pertama Negeri 6 Salatiga tahun 2016/2017. Sampel penelitian sejumlah 128 siswa ditentukan dengan rumus Slovin (α = 0,05). Teknik sampling, proporsional random sampling dirtentukan dengan undian. Data dikumpulkan dengan dokumentasi dan angket. Teknik analisis data menggunakan analisis jalur. Hasil penelitian menunjukkan ada kontribusi penampilan guru dalam pembelajaran, motivasi, dan fasilitas terhadap hasil belajar matematika dengan mediasi kedisiplinan belajar (10%, sig. = 0,011). Penampilan guru dalam pembelajaran berkontribusi secara langsung terhadap hasil belajar matematika (0,54%, sig. = 0,412). Motivasi belajar berkontribusi secara tidak langsung terhadap hasil belajar matematika melalui kedisiplinan belajar (22,1%, sig. = 0,000). Fasilitas belajar berkontribusi secara langsung terhadap hasil belajar matematika (0,0009%, sig. = 0.997). Kesimpulan dari penelitian ini adalah pembelajaran matematika di Sekolah Menengah Pertama menjadi baik karena dukungan dari penampilan guru dalam pembelajaran, motivasi, dan fasilitas dengan mediasi kedisiplinan belajar.
Deteriorated gene expression of selected calcium transporters in streptozotocin-induced diabetic hearts of Wistar rats
Authors: Dragún M. , Dóka G. , Máťuš M. , Křenek P. , Klimas J. 
Published: August 2018

Abstract

Aim: The aim is to identify the possible changes in the expression of genes, that regulate calcium homeostasis in cardiomyocytes in diabetes mellitus.

Methods: Male Wistar rats were randomized into two experimental protocols: short-term 5-days streptozotocin-induced diabetes protocol with 20 weeks old animals at the end of the protocol (total N = 20) and long-term 4-weeks protocol with 18 weeks of age at the end of the protocol (total N = 38). 50 mg/kg of streptozotocin (STZ) was administered in both protocols by a single intraperitoneal injection in 0,1M citrate buffer (pH = 4.5). Control group (CON) received only vehiculum. Gene expressions in samples of left heart ventricle were measured by RT-qPCR method.

Results: The expression of SERCA2a in short-term protocol was decreased. In long-term protocol, decreased SERCA2a, TRPC4 and TRPC6 mRNA levels were observed (*p < 0.05). SERCA2a and TRPC4 mRNA levels exhibited statistical monotonic correlation in STZ-treated group in long-term protocol.

Conclusions: In diabetes mellitus, the calcium homeostasis in cardiomyocytes is altered and there could be a relation between alteration of internal sarcoplasmatic stores and store-operated calcium entry.
LAYANAN POS PENDIDIKAN ANAK USIA DINI DALAM PENINGKATAN AKSES PENDIDIKAN ANAK USIA DINI
Authors: Tedjawati J.M. 
Published: August 2018

AbstrakTujuan penelitian ini yaitu untuk mendeskripsikan dan menganalisis peran layanan Pos-Pendidikan Anak Usia Dini (Pos-PAUD) dalam meningkatkan akses PAUD yang meliputi dukungan orangtua dan masyarakat, serta pelaksanaan layanan Pos-PAUD. Penelitian ini menggunakan pendekatan deskriptif kualitatif. Informasi layanan Pos-PAUD dikumpulkan dari empat kabupaten/kota pada tahun 2013. Hasil studi menemukan pertama, semua orang tua menyadari pentingnya dan bermanfaatnya. Selain itu, dukungan masyarakat didasarkan pada penerimaan program PAUD dan ikut serta dalam sosialisasi pentingnya PAUD. Kedua, layanan Pos-PAUD dilaksanakan dengan adanya peserta didik di sekitar lembaga; pendidiknya dari kader Posyandu, pembinaan kesejahteraan keluarga, bina keluarga balita, yang relatif hanya lulusan Sekolah Menengah Atas dan bekerja dengan “sukarela” tanpa imbalan; sarana prasarana dan biaya masih terbatas dalam penyelenggaraannya. Tingkat capaian tumbuhkembang anak dipengaruhi oleh pemberian layanan dalam pendidikan dan kesehatan. Pendidikan dilaksanakan antara lain melalui penanaman nilai agama (berdoa), jalinan komunikasi dan kerjasama antar anak, sehingga anak lebih mandiri dan mengalami perubahan berpikir. Layanan kesehatan dilakukan dengan penimbangan berat dan tinggi badan, imunisasi dan pemberian makanan dengan gizi seimbang melalui pemberian sehingga diperoleh fisik yang sehat. AbstractThe purpose of this study is to describe and analyze the role of Early Childhood Education Post (ECD Post) in improving access to early childhood education including the parental and community support, as well as the implementation of ECD Post service. This study used a qualitative descriptive approach. Information about the ECD Post service was collected from four districts/cities in 2013. The study found, first, all parents were aware of the importance and benefits of early childhood education. In addition, public support was based on the acceptance of early childhood programs and participation in the importance of early childhood dissemination. Second, ECD Post service was conducted by the participation of learners living close to the institution; educators were from Posyandu, fostering family welfare, parenting education (Bina Keluarga Balita), who were relatively only high school graduates and working voluntarily without reward; the implementation was running on limited infrastructure and funding. The level of children’s growth and development were affected by the provision of services in education and health. Education was carried out through the cultivation of religious values (praying) and also communication and cooperation among children in order to encourage children’s independency and a better thought process. Health services were performed by weight and height control, immunization, and provision of balanced nutrition through various meal menu in order to obtain a healthy physique.
KAJIAN PENYELENGGARAAN PENDIDIKAN KARAKTER DI SMA DAN SMK
Authors: - Sudiyono 
Published: August 2018

ABSTRAKPenelitian ini bertujuan untuk mendapatkan informasi tentang pelaksanaan pendidikan karakter, guna mendapatkan opsi kebijakan tentang strategi pendidikan karakter di sekolah. Metode penelitian menggunakan survei, menggunakan pendekatan deskriptif kualitatif dan analisis data menggunakan statistik deskriptif. Penelitian dilaksanakan di 10 kab/kota dengan sampel 40 SMA dan 40 SMK. Responden adalah kepala dinas pendidikan 10 orang, kepala sekolah 80 orang, guru 320 orang, dan siswa 800 orang. Hasil penelitian menunjukkan bahwa dari sisi kebijakan pemerintah daerah sebagian besar belum menerbitkan peraturan daerah yang terkait dengan pendidikan karakter. Sementara pada tingkat sekolah, kebijakan pelaksanaan pendidikan karakter umumnya dilaksanakan mengacu pada visi dan misi sekolah, sebagian besar sekolah mengintegrasikan dalam pembelajaran, pembiasaan, dan pembudayaan. Pelaksanaan pembiasaan dan pembudayaan yang dilakukan oleh guru masih belum konsisten, dan belum dievaluasi secara periodik. Direkomendasikan perlu adanya penguatan dan pembudayaan secara konsisten pelaksanaan pendidikan karakter dengan mengacu pada praktik sekolah terbaik dan meminimalkan hambatan pelaksanaannya. ABSTRACTThis study aimed to obtain information on the implementation of character education in academic and vocational high school in order to develop strategic policy options on character education in schools. The method used was survey, descriptive qualitative approach and data analysis using descriptive statistics. The research was conducted in 10 districts/cities with a sample of 80 schools (40 academic schools and 40 vocational schools). Respondents involved were 10 district head of education offices, 80 principals, 320 teachers, and 800 students. The results showed that in terms of policy, most regional government had yet to issue local regulations related to character education. While at the school level, policy implementation was generally implemented in reference to the vision and mission of the school. The vast majority of schools integrated learning, habituation, and familiarization. Implementation of habituation and familiarization done by teachers were still inconsistent, and had not been evaluated periodically. One of policy recommendation is the need to strengthen and develop a consistent implementation of character education referencing to the best practices and to minimize obstacles in implementation.
Using the Plan-Do-Study-Act (PDSA) Model for Continuous Quality Improvement of an Established Simulated Patient Program
Authors: Vordenberg Sarah. E. , Smith Michael A. , Diez Heidi L. , Remington Tami L. , Bostwick Jolene R. 
Published: August 2018

Objective: To describe the use of a continuous quality improvement process for strengthening our simulated patient (SP) program and the initial steps that have been implemented.
Innovation: A workgroup that included five clinical faculty with significant experience working with SPs and a strong interest in improving the SP program was developed. The Plan-Do-Study-Act model was used as it allowed for incremental quality improvement changes, in order to ensure a high-quality SP program designed to optimize student learning. Data were gathered from students, SPs, and faculty. Opportunities for improvement were prioritized based on anticipated benefits and available resources. Changes related to planning, implementation, and evaluation and feedback have been executed.
Critical Analysis: Changes related to planning that were implemented included developing handbooks for SPs, faculty, and graduate student instructors, as well as material for students in order to better describe the program. SPs are now referred to as “simulated” as opposed to “standardized” as part of a broader effort to clarify the purpose of SP interactions to students. Streamlined rubrics have been piloted, including electronic rubrics for first year students. SPs are being trained on fewer cases, in order to improve the training program. When possible, activities now take place in one large classroom instead of many small classrooms to improve oversight. Finally, additional feedback has been obtained from SPs via a retreat. These changes have been well received by students, SPs, and faculty.
Next Steps: The collection of this data and initial quality improvement changes provided a basis for hiring a full-time employee who will: dedicate 50% of their time to programmatic assessment of the SP program, support faculty with logistics and training, and be the face of our program to the students and SPs. Further, formal quantitative and qualitative assessment of the SP program has begun.

Type: Note