bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Measurement of Wood in Construction Dust Samples: A Furnace Based Thermal Gravimetric Approach
Authors: Stacey Peter , Simpson Andrew , Hambling Susan 
Published: August 2019

Abstract
A furnace-based thermal gravimetric method was developed to measure wood in inhalable construction dust. The application of this method showed that reliance on the inhalable concentrations alone may substantially overestimate carpenters’ exposures to wood dust at construction worksites. Test samples were prepared by collecting aerosols of gypsum, calcite, quartz, concrete, and wood dust onto quartz fibre filters using the Button inhalable sampler. The average difference between the measured and loaded mass of wood is 2% over the whole analytical range. Ninety percent of thermogravimetric measurements on all test samples (n = 35) were 13% or less. The limit of detection was measured as 0.065 mg. The thermal gravimetric method was applied to samples collected from four new build construction sites and one shop fitting worksite. The workplace inhalable wood dust results ranged from 15% to 104% of the total inhalable dust values. In addition, an x-ray diffraction (XRD) Rietveld method was applied as a complimentary approach to explain the composition of the remaining inhalable dust. Most combined thermal gravimetric and XRD measurements were within 10% of the total inhalable dust mass values, determined gravimetrically. Ninety-five percent were within 26%. The median proportion of mineral dust containing gypsum, calcite, quartz, dolomite, or rutile was 30%. The proportion of mineral dust on individual filters varied considerably.
Constructing functional cuticles: analysis of relationships between cuticle lipid composition, ultrastructure and water barrier function in developing adult maize leaves
Authors: Bourgault Richard , Matschi Susanne , Vasquez Miguel , Qiao Pengfei , Sonntag Annika , Charlebois Caleb , Mohammadi Marc , Scanlon Michael J , Smith Laurie G , Molina Isabel 
Published: August 2019

AbstractBackground and AimsPrior work has examined cuticle function, composition and ultrastructure in many plant species, but much remains to be learned about how these features are related. This study aims to elucidate relationships between these features via analysis of cuticle development in adult maize (Zea mays L.) leaves, while also providing the most comprehensive investigation to date of the composition and ultrastructure of adult leaf cuticles in this important crop plant.MethodsWe examined water permeability, wax and cutin composition via gas chromatography, and ultrastructure via transmission electron microscopy, along the developmental gradient of partially expanded adult maize leaves, and analysed the relationships between these features.Key ResultsThe water barrier property of the adult maize leaf cuticle is acquired at the cessation of cell expansion. Wax types and chain lengths accumulate asynchronously over the course of development, while overall wax load does not vary. Cutin begins to accumulate prior to establishment of the water barrier and continues thereafter. Ultrastructurally, pavement cell cuticles consist of an epicuticular layer, and a thin cuticle proper that acquires an inner, osmiophilic layer during development.ConclusionsCuticular waxes of the adult maize leaf are dominated by alkanes and alkyl esters. Unexpectedly, these are localized mainly in the epicuticular layer. Establishment of the water barrier during development coincides with a switch from alkanes to esters as the major wax type, and the emergence of an osmiophilic (likely cutin-rich) layer of the cuticle proper. Thus, alkyl esters and the deposition of the cutin polyester are implicated as key components of the water barrier property of adult maize leaf cuticles.
Takotsubo Cardiomyopathy Induced by Epinephrine Infiltration for Liposuction: Broken Heart Syndrome
Authors: Maes Sebastiaan , Dhooghe Nicolas Simon James Jeremy , Schotte Henri , Cattoir Steffi , Jacobs Tom Frans , Van Landuyt Koenraad 
Published: August 2019

Abstract

Broken heart syndrome, more commonly known as Takotsubo cardiomyopathy (TCM), is an acute cardiac condition. It is characterized by regional cardiac wall motion abnormalities triggered by physical or emotional stress or administration of catecholamines such as epinephrine. The initial clinical presentation is similar to an acute coronary syndrome and must be ruled out. Visualization of the characteristic wall motion will trigger the diagnosis of TCM. In this case report, we present a 50-year-old woman with additional liposuction and fat grafting after autologous breast reconstruction. Shortly after infiltration with a solution containing epinephrine to achieve vasoconstriction, hypotension and bradycardia was noticed. This escalated into full asystole for which cardiac resuscitation was required. ST-elevations and a decrease in systolic function were clear indicators for urgent coronarography and ventriculography. These confirmed the diagnosis of TCM. Infiltration with epinephrine-containing products to achieve local vasoconstriction is used routinely. Medical professionals should be aware that this can trigger a TCM with an estimated mortality rate of 5%. No evidence of a specific preventive measure currently exists. We know that women with a neurologic or psychiatric comorbidity and high levels of stress are more at risk. Reducing stress and anxiolytic medication prior to surgery could be useful. We also know that the cardiac wall motion abnormality is mainly related to β-adrenoreceptors. The use of a selective α-adrenoreceptor agonist could be considered. Further research in the pathophysiology and incidence of TCM could improve identification of patients at risk and lead to more effective prevention and treatment.

Level of Evidence: 5
An omics perspective on drug target discovery platforms
Authors: Paananen Jussi , Fortino Vittorio 
Published: August 2019

Abstract
The drug discovery process starts with identification of a disease-modifying target. This critical step traditionally begins with manual investigation of scientific literature and biomedical databases to gather evidence linking molecular target to disease, and to evaluate the efficacy, safety and commercial potential of the target. The high-throughput and affordability of current omics technologies, allowing quantitative measurements of many putative targets (e.g. DNA, RNA, protein, metabolite), has exponentially increased the volume of scientific data available for this arduous task. Therefore, computational platforms identifying and ranking disease-relevant targets from existing biomedical data sources, including omics databases, are needed. To date, more than 30 drug target discovery (DTD) platforms exist. They provide information-rich databases and graphical user interfaces to help scientists identify putative targets and pre-evaluate their therapeutic efficacy and potential side effects. Here we survey and compare a set of popular DTD platforms that utilize multiple data sources and omics-driven knowledge bases (either directly or indirectly) for identifying drug targets. We also provide a description of omics technologies and related data repositories which are important for DTD tasks.
CROSSalive: a web server for predicting thein vivostructure of RNA molecules
Authors: Ponti Riccardo Delli , Armaos Alexandros , Vandelli Andrea , Tartaglia Gian Gaetano 
Published: August 2019

AbstractMotivationRNA structure is difficult to predict in vivo due to interactions with enzymes and other molecules. Here we introduce CROSSalive, an algorithm to predict the single- and double-stranded regions of RNAs in vivo using predictions of protein interactions.ResultsTrained on icSHAPE data in presence (m6a+) and absence of N6 methyladenosine modification (m6a-), CROSSalive achieves cross-validation accuracies between 0.70 and 0.88 in identifying high-confidence single- and double-stranded regions. The algorithm was applied to the long non-coding RNA Xist (17 900 nt, not present in the training) and shows an Area under the ROC curve of 0.83 in predicting structured regions.Availability and implementationCROSSalive webserver is freely accessible at http://service.tartaglialab.com/new_submission/crossaliveSupplementary informationSupplementary data are available at Bioinformatics online.
Adaptive empirical pattern transformation (ADEPT) with application to walking stride segmentation
Authors: Karas Marta , Stra̧czkiewicz Marcin , Fadel William , Harezlak Jaroslaw , Crainiceanu Ciprian M , Urbanek Jacek K 
Published: August 2019

Summary
Quantifying gait parameters and ambulatory monitoring of changes in these parameters have become increasingly important in epidemiological and clinical studies. Using high-density accelerometry measurements, we propose adaptive empirical pattern transformation (ADEPT), a fast, scalable, and accurate method for segmentation of individual walking strides. ADEPT computes the covariance between a scaled and translated pattern function and the data, an idea similar to the continuous wavelet transform. The difference is that ADEPT uses a data-based pattern function, allows multiple pattern functions, can use other distances instead of the covariance, and the pattern function is not required to satisfy the wavelet admissibility condition. Compared to many existing approaches, ADEPT is designed to work with data collected at various body locations and is invariant to the direction of accelerometer axes relative to body orientation. The method is applied to and validated on accelerometry data collected during a $450$-m outdoor walk of $32$ study participants wearing accelerometers on the wrist, hip, and both ankles. Additionally, all scripts and data needed to reproduce presented results are included in supplementary material available at Biostatistics online.
Abstract goal representation in visual search by neurons in the human pre-supplementary motor area
Authors: Wang Shuo , Mamelak Adam N , Adolphs Ralph , Rutishauser Ueli 
Published: August 2019

Abstract
The medial frontal cortex is important for goal-directed behaviours such as visual search. The pre-supplementary motor area (pre-SMA) plays a critical role in linking higher-level goals to actions, but little is known about the responses of individual cells in this area in humans. Pre-SMA dysfunction is thought to be a critical factor in the cognitive deficits that are observed in diseases such as Parkinson’s disease and schizophrenia, making it important to develop a better mechanistic understanding of the pre-SMA’s role in cognition. We simultaneously recorded single neurons in the human pre-SMA and eye movements while subjects performed goal-directed visual search tasks. We characterized two groups of neurons in the pre-SMA. First, 40% of neurons changed their firing rate whenever a fixation landed on the search target. These neurons responded to targets in an abstract manner across several conditions and tasks. Responses were invariant to motor output (i.e. button press or not), and to different ways of defining the search target (by instruction or pop-out). Second, ∼50% of neurons changed their response as a function of fixation order. Together, our results show that human pre-SMA neurons carry abstract signals during visual search that indicate whether a goal was reached in an action- and cue-independent manner. This suggests that the pre-SMA contributes to goal-directed behaviour by flexibly signalling goal detection and time elapsed since start of the search, and this process occurs regardless of task. These observations provide insights into how pre-SMA dysfunction might impact cognitive function.
Sex- and Poverty-Specific Patterns in Cardiovascular Disease Mortality Associated With Human Immunodeficiency Virus, New York City, 2007–2017
Authors: Hanna David B , Ramaswamy Chitra , Kaplan Robert C , Kizer Jorge R , Daskalakis Demetre , Anastos Kathryn , Braunstein Sarah L 
Published: August 2019

Abstract

Background
Human immunodeficiency virus (HIV) may affect the risk of death due to cardiovascular disease (CVD) differently in men versus women.

Methods
We examined CVD mortality rates between 2007 and 2017 among all New York City residents living with HIV and aged 13+ by sex, using data from city HIV surveillance and vital statistics and the National Death Index. Residents without HIV were enumerated using modified US intercensal estimates. We determined associations of HIV status with CVD mortality by sex and neighborhood poverty, defined as the percent of residents living below the federal poverty level, after accounting for age, race/ethnicity, and year.

Results
There were 3234 CVD deaths reported among 147 915 New Yorkers living with HIV, with the proportion of deaths due to CVD increasing from 11% in 2007 to 22% in 2017. The age-standardized CVD mortality rate was 2.7/1000 person-years among both men and women with HIV. The relative rate of CVD mortality associated with HIV status was significantly higher among women (adjusted rate ratio [aRR] 1.7, 95% confidence interval [CI] 1.6–1.8) than men (aRR 1.2, 95% CI 1.1–1.3) overall, and within strata defined by neighborhood poverty. Sex differences in CVD mortality rates were the greatest when comparing individuals living with HIV and having detectable HIV RNA and CD4+ T-cell counts &lt;500 cells/uL with individuals living without HIV.

Conclusions
Among people with HIV, 1 in 5 deaths is now associated with CVD. HIV providers should recognize the CVD risk among women with HIV, and reinforce preventive measures (eg, smoking cessation, blood pressure control, lipid management) and viremic control among people living with HIV regardless of neighborhood poverty to reduce CVD mortality.
Human immunodeficiency virus (HIV) increases cardiovascular disease mortality risks to a greater degree among women than men, even after accounting for neighborhood poverty. HIV providers should emphasize cardiovascular disease prevention (eg, smoking cessation, hypertension control, lipid management) and viremic control.
The NoisyOffice Database: A Corpus To Train Supervised Machine Learning Filters For Image Processing
Authors: Castro-Bleda M J , España-Boquera S , Pastor-Pellicer J , Zamora-Martínez F 
Published: August 2019

Abstract
This paper presents the ‘NoisyOffice’ database. It consists of images of printed text documents with noise mainly caused by uncleanliness from a generic office, such as coffee stains and footprints on documents or folded and wrinkled sheets with degraded printed text. This corpus is intended to train and evaluate supervised learning methods for cleaning, binarization and enhancement of noisy images of grayscale text documents. As an example, several experiments of image enhancement and binarization are presented by using deep learning techniques. Also, double-resolution images are also provided for testing super-resolution methods. The corpus is freely available at UCI Machine Learning Repository. Finally, a challenge organized by Kaggle Inc. to denoise images, using the database, is described in order to show its suitability for benchmarking of image processing systems.
The Early Experience With Vedolizumab in the United States
Authors: Kochar Bharati , Jiang Yue , Winn Aaron , Barnes Edward L , Martin Christopher F , Long Millie D , Kappelman Michael D 
Published: August 2019

Abstract

Background
Post-marketing studies of new inflammatory bowel disease (IBD) therapies are needed to establish clinical effectiveness and safety in clinical practice. We aimed to describe the U.S. experience with vedolizumab in a commercially insured population.

Methods
We conducted a retrospective cohort study in Quintiles-IMS Legacy PharMetrics Adjudicated Claims Database from May 2014 to June 2016. We included new vedolizumab users with Crohn disease (CD) and ulcerative colitis (UC) between 18 and 64 years with ≥12 months of continuous enrollment prior to initiating vedolizumab. Outcomes included treatment persistence &gt;14 weeks, late steroid use, IBD-related surgery and infections associated with hospitalization. We built multivariable regression models to identify predictors of treatment persistence and late steroid use.

Results
We identified 269 CD and 187 UC vedolizumab initiators. Only 60% of CD patients and 56% of UC patients remained on vedolizumab after 14 weeks without IBD-related hospitalization, surgery, and corticosteroid use. There were no significant predictors of treatment persistence. Steroid use in the first 2 months of vedolizumab initiation was a significant predictor of late steroid use in CD (odds ratio: 23.34; 95% confidence interval: 5.10–153.89). In the 6 months after vedolizumab initiation, 1.9% of CD and 5.9% of UC patients had an IBD-related surgery. Serious infections were &lt;4%.

Conclusions
These data reflect the early U.S. experience with vedolizumab. The population-level response to vedolizumab therapy is just &gt;50%. Steroids at the time of vedolizumab initiation is the strongest predictor of late steroid use in CD. Rates of surgery and serious infections are low.
Glut-1 explains the evolutionary advantage of the loss of endogenous vitamin C-synthesis
Authors: Hornung Tabea C , Biesalski Hans-Konrad 
Published: August 2019

AbstractIntroductionDuring evolution, some species including humans, monkeys and fruit bats lost the ability for ascorbic acid (AA) biosynthesis due to inactivation of the enzyme l-gulono-lactone oxidase (GLO) and subsequently became dependent on dietary vitamin C. There are four current hypotheses in relation to the benefit of vitamin C dependence in the context of adaptation and reproduction. Here we advance and test a new ‘electron transfer hypothesis’, which focusses on the role of the expression of glucose transporter 1 (Glut-1) in red blood cells (RBCs) in recycling vitamin C, thereby increasing the efficiency of micronutrient uptake.MethodsTo evaluate the benefit of Glut-1 expression, we determined vitamin C uptake into RBCs and potential release from two different species, humans with l-Gulono-lactone-oxidase (GLO-loss) and pigs with functional GLO.ResultsThe oxidized form of vitamin C (dehydroascorbate, DHA) was transported into human RBCs via Glut-1. There was no transport of either the reduced (AA) or the oxidized vitamin in pig erythrocytes.ConclusionWe propose that the transport of vitamin C increases an intracellular electron pool, which transfers electrons from intracellular ascorbate to extracellular substances like ascorbyl free radical or DHA, resulting in 100-fold smaller daily requirement of this essential redox sensitive micronutrient. This would be an advantage during seasonal changes of the availability from food and may be the key for the survival of individuals without vitamin C biosynthesis.Lay Summary40 million years ago some individuals lost the ability to synthesize vitamin C. Why did they survive such as humans until now? Individuals with a specific glucose transporter Glut-1 on their erythrocytes which transports vitamin C need less and are protected from scarcity due to seasons and food competitors.
Reported mortality with rotating sheaths vs. laser sheaths for transvenous lead extraction
Authors: Diaz Celso L , Guo Xiaofan , Whitman Isaac R , Marcus Gregory M , Pellegrini Cara N , Beygui Ramin E , Lee Sun Yong , Lee Byron K 
Published: August 2019

Abstract

Aims
Rotating sheaths and laser sheaths are commonly used for transvenous lead extraction. This study aims to compare observed mortality between both approaches.

Methods and results
The Manufacturer and User Facility Device Experience database was searched from 2011 to 2016 to determine number of deaths associated with each sheath. An independent analytics firm provided estimates for number of cases done, allowing calculation of market share. A sensitivity analysis was performed to determine relative risk (RR) of mortality at the calculated market share (36% rotating/64% laser) and two others. Additional sensitivity analyses assumed underreporting of deaths associated with rotating sheaths. An estimated 50 545 extractions were performed. Thirteen deaths were associated with rotating sheaths compared to 167 with laser sheaths. Of these, 92% (rotating) and 95% (laser) were due to cardiovascular injury. At the calculated market share, the RR of death was 7.2 times greater with laser sheaths [95% confidence interval (CI) 4.1–12.7, P < 0.0001]. At market share estimates of 25% rotating/75% laser and 45% rotating/55% laser, the RR of death with laser sheaths was 4.3 (95% CI 2.4–7.5, P < 0.0001) and 10.5 times greater (95% CI 6.0–18.5, P < 0.0001), respectively. The RR of death remained significant when assuming deaths with rotating sheaths were underreported and when deaths using both sheaths were attributed to the rotating sheath.

Conclusions
Lead extraction with laser sheaths appears to be associated with a higher risk of mortality compared to rotating sheaths. Further studies are warranted to confirm this finding.
Development and cohort study of an audit approach to evaluate patient management in family practice in the UK: the 7S tool
Authors: Fisher Stacey J , Margerison Lawrence N , Jonker Leon 
Published: August 2019

Abstract

Background
In the UK, there is increased pressure on general practitioners’ time due to an increase in (elderly) population and a shortage of general practitioners. This means that time has to be used efficiently, whilst optimizing adherence to consistent, appropriate and timely provision of care.

Objective(s)
Create an audit tool that assists general practitioners and family practice staff to evaluate if patients are managed as effectively as possible, and to test the usefulness of this tool in a family practice.

Methods
The ‘7S’ audit tool has seven outcome elements; these broadly stand for what the actual and desired patient contact outcome was, or should have been. Terms include ‘surgery’, ‘speak’ and ‘specific other’ for an appointment at the practice, by telephone or with a dedicated specialist such as a practice nurse or phlebotomist, respectively.

Results
A very small, rural, general practice in the UK was audited using the 7S tool. Five hundred patient contacts were reviewed by an independent general practitioner and the decision made if the mode of contact was appropriate or not for each case; in one of the three cases, the choice of care provision was inappropriate and chronic disease cases contributed most to this. General practitioners instigated the majority of poor patient management choices, and chronic disease patients were frequently seen in suboptimal settings.

Conclusions
Inefficiencies in the management of patients in family practice can be identified with the 7S audit tool, thereby producing evidence for staff education and service reconfiguration.