bluuebunny/crossref_metadata_2025_split huggingface dataset:
Вплив поліморфізму гена інтерлейкіну-10 на перебіг муковісцидозу в дітей
Authors: Drobova N.M. 
Published: October 2018

Актуальність. Муковісцидоз (МВ) — генетичне захворювання, перебіг якого залежить не тільки від мутації гена трансмембранного регулятора МВ, але й від інших генів-модифікаторів. Ген інтерлейкіну-10 (ІЛ-10) входить до переліку таких модифікуючих факторів. Мета. Удосконалення медичної допомоги хворим на МВ шляхом уточнення прогнозу перебігу на підставі визначення патогенетичної ролі поліморфізму гена-модифікатора запалення ІЛ-10. Матеріали та методи. 42 дитини з діагнозом МВ обстежені за стандартною методикою. Визначення поліморфізму G1082A гена IL-10 проводили за допомогою полімеразної ланцюгової реакції в реальному часі. ДНК виділяли з клітин букального епітелію. Результати. У групі дітей, хворих на МВ, із мутацією G1082A гена IL-10 встановлена більш рання маніфестація при кишкових симптомах і більш пізня — при легеневих ознаках, тяжкий перебіг захворювання (зниження об’єму форсованого видоху за 1 секунду — 70,0 (65,0; 72,0) %), ранній розвиток бронхоектазів легенів (72 %) та пневмофіброзу (95,4 %), цирозу печінки (36,4 %), переважання серед респіраторних збудників Pseudomonas aeruginosa (59,1 %) у бактеріальному пейзажі мокротиння, зміни імунного статусу (підвищення циркулюючих імунних комплексів — 8,65 (7,6; 10,55) од. та зниження індексу активності нейтрофілів спонтанного — 0,31 (0,24; 0,78) од. Висновки. Охарактеризовано фенотип МВ, який асоційований з мутацією гена IL-10 G1082A.
Преморбидные нарушения функционального состояния поджелудочной железы у детей с хронической гастродуоденальной патологией
Authors: Sorokman T.V. , Ostapchuk V.G. 
Published: October 2018

Актуальность. Вторичная панкреатическая недостаточность в педиатрической практике возникает чаще и может проявляться в любом возрасте как на фоне алиментарных нарушений, так и при различных воспалительных заболеваниях верхних отделов пищеварительного тракта. Цель. Исследование функционального состояния поджелудочной железы (ПЖ) у детей при хронической гастродуоденальной патологии. Материалы и методы. Исследование проведено на базе гастроэнтерологического отделения Черновицкой областной клинической детской больницы в течение 2013–2018 гг. Основную клиническую группу составили 64 ребенка в возрасте 8–18 лет с хронической гастродуоденальной патологией: у 29 детей — хронический гастрит, у 30 детей — хронический гастродуоденит, у 5 детей — язвенная болезнь луковицы двенадцатиперстной кишки. Всем детям проводили общеклинические исследования, ультразвуковое исследование (УЗИ) органов брюшной полости, фиброгастродуоденоскопию, Ph-метрию, 3-кратное копрологическое исследование, определяли активность a-амилазы, липазы сыворотки крови, диастазы мочи, концентрацию фекальной эластазы-1 (ФЕ-1) в кале, С-пептида в сыворотке крови, уровень глюкозы в крови, пероральный глюкозотолерантный тест. Статистическая обработка полученных данных осуществлена с помощью программ «Статистика 6.0». Результаты. Ведущими были болевой (93,7 %), диспептический (90,6 %) и астеноневротический синдромы (57,8 %), нарушение моторно-эвакуаторной функции желудка и двенадцатиперстной кишки в виде гастроэзофагеального и дуоденогастрального рефлюксов. У 35,9 ± 3,7 % лиц выявлены признаки поражения ПЖ: утолщение хвоста железы и повышение ее эхогенности при УЗИ, амилорея, креаторея, стеаторея I и II типа, изменения уровня a-амилазы, ФЕ-1, «плоские» кривые глюкозотолерантного теста, что указывало на начальные нарушения углеводного обмена. Медиана уровня С-пептида для детей основной группы составила 1,29 нг/мл (доверительный интервал (ДИ) 1,11–3,42), для детей группы сравнения — 0,89 нг/мл (ДИ 0,23–1,12). Тенденция к повышению уровня С-пептида зарегистрирована у 12 детей с избытком массы тела, у которых выявлена «плоская» сахарная кривая, а также нарушение экзокринной функции ПЖ на фоне ультразвуковых ее изменений. Выводы. Выявленные изменения функционального состояния ПЖ у обследованных детей указывают на необходимость определения функционального состояния железы и его контроль в динамике лечения гастродуоденальной патологии.
Acute Kidney Injury among Hospitalized Children in China
Authors: Xu Xin , Nie Sheng , Zhang Aihua , Mao Jianhua , Liu Hai-Peng , Xia Huimin , Xu Hong , Liu Zhangsuo , Feng Shipin , Zhou Wei , Liu Xuemei , Yang Yonghong , Tao Yuhong , Feng Yunlin , Chen Chunbo , Wang Mo , Zha Yan , Feng Jian-Hua , Li Qingchu , Ge Shuwang , Chen Jianghua , He Yongcheng , Teng Siyuan , Hao Chuanming , Liu Bi-Cheng , Tang Ying , He Wenjuan , He Pinghong , Hou Fan Fan 
Published: October 2018

Background and objectivesHigh-quality epidemiologic data on AKI in children are particularly lacking in developing countries. This study aimed to assess the epidemiology and clinical correlates of AKI among hospitalized children in China.Design, setting, participants, & measurementsWe performed a multicenter study, in a cohort of hospitalized children aged 1 month to 18 years, from 25 general and children’s hospitals in China during 2013–2015. We obtained patient-level data from the electronic hospitalization information system and laboratory databases of all children who had at least two serum creatinine tests within any 7-day window during their first 30 days of hospitalization. We identified AKI events according to the creatinine criteria of Kidney Disease Improving Global Outcomes. The in-hospital outcomes of AKI, including mortality, kidney recovery, and length of stay, were assessed. We estimated the corresponding hazard ratios using a Cox proportional hazard model, with adjustment for age, sex, comorbidities, and clinical procedures.ResultsA total of 19,908 (20%) patients with AKI were identified among 101,836 pediatric inpatients, of which 7220 (7%) were community acquired and 12,688 (13%) were hospital acquired. Up to 96% of these AKI events were not diagnosed on the discharge records. The cumulative incidence of AKI in infants (28%) was twice that in adolescents (12%). The profiles of risk factors differed between community-acquired and hospital-acquired AKI and varied with age. Diarrhea and sepsis were the top risk factors for community-acquired AKI, each contributing 6% of the risk. Congenital heart disease/cardiac surgery was the major risk factor for hospital-acquired AKI, contributing to 19% of cases. Exposure to nephrotoxic drugs, mostly nonsteroidal anti-inflammatory drugs and proton pump inhibitors, was common in hospitalized children and was associated with a higher risk of AKI. Death occurred in 842 out of 19,908 patients (4%) with AKI versus 450 out of 81,478 children (0.5%) without AKI. The risk of in-hospital death was higher among children with severe AKI, shock, and respiratory failure. Pediatric AKI was associated with longer hospital stay and higher daily cost, even after adjustment for covariates.ConclusionsPediatric AKI is common and is substantially underdiagnosed in China.
The US Healthcare Facilities Management Industry's State of Hiring from Facilities Management Academic Programs
Authors: Call Steven , Sullivan Kenneth , Smithwick Jake 
Published: October 2018

ABSTRACT
The purpose of this research is to better understand the current state of US healthcare FM industry hiring practices from FM academic programs. A national survey was distributed to healthcare FM directors to collect quantifiable information on healthcare organizations and their hiring practices from FM academic programs. Survey respondents that hired directly from an academic program were contacted for phone interviews. Results indicate that the healthcare FM industry is hiring very few college interns and new college graduates for entry-level management jobs. This paper is valuable in establishing the current state of the US healthcare industry's hiring practices from FM academic programs. Results will be used to better understand the needs and barriers of entry-level FM employment from FM academic programs as a potential source for new talent to the healthcare FM industry.
Pemahaman dan Penerapan Sistem Among Ki Hadjar Dewantara pada Usia Wiraga
Authors: Susanto Yenita Heri , Jaziroh Amnahul 
Published: October 2018

Pendidikan anak usia dini merupakan pendidikan yang fundamental karena masa awal anak mulai mengenyam pendidikan. Menurut sistem among Ki Hadjar Dewantara, anak usia dini dikategorikan dalam usia “Wiraga”. Tujuan penelitian ini untuk mengetahui pemahaman dan penerapan sistem among Ki Hadjar Dewantara pada usia wiraga. Metode penelitian ini yaitu kualitatif dengan pendekatan studi kasus. Teknik pengumpulan data dilakukan dengan observasi dan wawancara kepada kepala sekolah dan 3 guru Sekolah Alam Ramadhani Kediri. Hasil penelitian meliputi: Pemahaman sistem among ialah seorang guru mendampingi, melayani, mengingatkan, serta sebagai seorang teman. Usia wiraga dipahami sebagai usia 0-8 tahun, dimana anak banyak bermain dan olah gerak (motorik kasar). Sistem among di Sekolah Alam Ramadhani diterapkan sesuai dengan kondisi dan tugas perkembangan anak pada usia yang dia miliki. Pendidikan bagi anak usia dini seharusnya bersifat memerdekakan anak selama tidak membahayakan dirinya sehingga sistem among dapat dijadikan sebagai suatu sistem yang tepat bagi pendidikan anak usia dini.Kata kunci : anak usia dini, sistem among, ki hadjar dewantara
THE CONTRIBUTIONS OF TOURISM INDUSTRY TOWARD STUDENTS’ SPEAKING MOTIVATION IN LEARNING ENGLISH
Authors: Umar Umar , Suparman Suparman 
Published: October 2018

This research aimed to find out The Contributions of Tourism Industry toward Students’ Speaking Motivation in Learning English on Students who live around Tourism Object. The participants of this research proposal is the students who live around tourism object (case study at Kencana Beach Cottages in Labuhan Badas Sumbawa Besar). The present study used mixed method. It contain to be examined in relation to quantitative and qualitative methods of data collection and analysis. The instrument used in collecting data was questionnaire, speaking test and observation. Questionnaire and speaking test used descriptive statistics of frequencies and percentages. It was analyzed by using SPSS Program.Observation was analyzed by using qualitative method. Based on the data analysis technique above, it was found out the the contributions oftourism industry toward students’ speaking motivation in learning English and to know how the contribution of tourism industry toward students’ speaking motivation in English.
Reverse-Phase Chromatographic Determination and Intrinsic Stability Behavior of 5-[(4-Chlorophenoxy)Methyl]-1,3,4-Oxadiazole-2-Thiol
Authors: Shehzadi Naureen , Hussain Khalid , Islam Muhammad , Bukhari Nadeem Irfan , Khan Muhammad Tanveer , Salman Muhammad , Siddiqui Sabahat Zahra , Rehman Aziz-Ur , Abbasi Muhammad Athar 
Published: October 2018

Abstract
The study describes the development and preliminary validation of a simple reverse-phase chromatographic method for determination of a novel drug candidate, 5-[(4-chlorophenoxy) methyl]-1,3,4-oxadiazole-2-thiol (OXCPM), in bulk and stressed solution, in order to find out the intrinsic stability behavior of the compound. Isocratic elution was carried out at a flow rate of 1.0 mL min-1 through a Promosil C18 column maintained at 25 °C, using the mobile phase comprising acetonitrile and aqueous o-H3PO4 (pH 2.67) (1:1, V/V). Detection was performed at 258 nm. The response of the detector was linear in a concentration range of 1.25-50.00 μg mL-1 with the correlation coefficient of 0.9996 ± 0.0001. Cumulative intra-day, inter-day and inter-instrument accuracy (99.5 ± 1.0, 100.2 ± 1.0 and 100.3 ± 0.4 %, resp.) with RSD less than 5 % indicated that the method was accurate and precise. The resolution and selectivity factor (>2 and >1, resp.), particularly in copper metal- and dry-heat-stress solutions, depicted the selectivity of the method. OXCPM remained stable under hydrolytic (acidic and neutral pH, ≤ 37 °C), photolytic and moist heat stress conditions. Under alkaline conditions (hydrolytic and photolytic), polar products were formed that eluted very fast through the column (tR < 3.75 min). At room temperature, the compound was susceptible to oxidation by hydrogen peroxide and transition metals. The ionogram of most of the stress solutions indicated the presence of a product having m/z 256, which might be a result of N- or Smethylation or -SH oxidation. The results of the study indicate that the method is selective, sensitive and suitable to be used for determination of OXCPM in bulk and under stress conditions.
Acalypha Wilkesiana ‘Java White’: Identification of Some Bioactive Compounds by Gc-Ms and Their Effects on Key Enzymes Linked to Type 2 Diabete
Authors: Oyebode Olajumoke A. , Erukainure Ochuko L. , Koorbanally Neil A. , Islam Md. Shahidul 
Published: October 2018

Abstract
In this study, we identified bioactive compounds from the ethanolic extracts of the leaves, stem bark and root bark of Acalypha wilkesiana through GC-MS analysis and investigated the effects of these extracts on some of the enzymes linked to type 2 diabetes. Plant parts were extracted sequentially with ethyl acetate, ethanol and water. GC-MS analysis revealed the presence of long-chain alkyl acids, esters, ketones and alcohols including phytol and phytol acetate along with some secondary metabolites such as xanthone, vitamin E and various types of sterols including stigmasterol, campesterol and sitosterol. Ethanolic extracts of all the parts showed a dose- -dependent inhibition of α-glucosidase and α-amylase activity. The extracts also demonstrated anti-lipase activity. The ethanolic extract of root bark showed the highest inhibition of enzymes compared to other extracts. The EC50 values (concentrations for 50 % inhibition) of α-glucosidase, α-amylase and lipase inhibition were 35.75 ± 1.95, 6.25 ± 1.05 and 101.33 ± 5.21 μg mL-1, resp. The study suggests that A. wilkesiana ethanolic extracts have the ability to inhibit the activity of enzymes linked to type 2 diabetes. Further studies are needed to confirm the responsible bioactive compounds in this regard.
Chloroquine Urea Derivatives: Synthesis and Antitumor Activity in Vitro
Authors: Pavić Kristina , Rajić Zrinka , Mlinarić Zvonimir , Uzelac Lidija , Kralj Marijeta , Zorc Branka 
Published: October 2018

Abstract
In the current paper, we describe the design, synthesis and antiproliferative screening of novel chloroquine derivatives with a quinoline core linked to a hydroxy or halogen amine through a flexible aminobutyl chain and urea spacer. Synthetic pathway leading to chloroquine urea derivatives 4-10 includes two crucial steps: i) synthesis of chloroquine benzotriazolide 3 and ii) formation of urea derivatives through the reaction of compound 3 with the corresponding amine. Testing of antiproliferative activity against four human cancer cell lines revealed that chloroquine urea derivatives 9 and 10 with aromatic moieties show activity at micromolar concentrations. Therefore, these molecules represent interesting lead compounds that might provide an insight into the design of new anticancer agents.
Yesterday masked, today modified; what do mycotoxins bring next?
Authors: Kovač Marija , Šubarić Drago , Bulaić Mateja , Kovač Tihomir , Šarkanj Bojan 
Published: October 2018

Abstract
Mycotoxins are secondary metabolites produced by toxigenic fungi in crops worldwide. In (micro)organisms such as plants, fungi, bacteria, or animals they may be further metabolised and modified, but this is also true for food processing, which may lead to a wide range of masked mycotoxin forms. These often remain undetected by analytical methods and are the culprits for underestimates in risk assessments. Furthermore, once ingested, modified mycotoxins can convert back to their parent forms. This concern has raised the need for analytical methods that can detect and quantify modified mycotoxins as essential for accurate risk assessment. The promising answer is liquid chromatography-mass spectrometry. New masked mycotoxin forms are now successfully detected by iontrap, time-of-flight, or high-resolution orbitrap mass spectrometers. However, the toxicological relevance of modified mycotoxins has not been fully clarified.
Whole blood exchange transfusion as a promising treatment of aluminium phosphide poisoning
Authors: Zamani Nasim , Hassanian-Moghaddam Hossein , Ebrahimi Sakine 
Published: October 2018

Abstract
A 37-year-old male was referred to us about one hour after deliberate ingestion of two 3-gram aluminium phosphide (ALP) tablets. Three hours after admission, his blood pressure dropped to 85/55 mmHg, his heart rate increased to 120 bpm, O2 saturation dropped to 82 %, and the electrocardiogram showed junctional rhythm. We started whole blood exchange, and gross haematuria and jaundice ensued. However, his blood pressure increased, arrhythmia resolved itself, and he was extubated two days after the transfusion was completed. He was sent home seven days after admission completely symptom-free. We believe this treatment may be successfully applied in ALP-poisoned patients.
Bibo Stabilisation of Continuous–Time Takagi–Sugeno Systems under Persistent Perturbations and Input Saturation
Authors: Salcedo José V. , Martínez Miguél , García-Nieto Sergio , Hilario Adolfo 
Published: October 2018

Abstract
This paper presents a novel approach to the design of fuzzy state feedback controllers for continuous-time non-linear systems with input saturation under persistent perturbations. It is assumed that all the states of the Takagi-Sugeno (TS) fuzzy model representing a non-linear system are measurable. Such controllers achieve bounded input bounded output (BIBO) stabilisation in closed loop based on the computation of inescapable ellipsoids. These ellipsoids are computed with linear matrix inequalities (LMIs) that guarantee stabilisation with input saturation and persistent perturbations. In particular, two kinds of inescapable ellipsoids are computed when solving a multiobjective optimization problem: the maximum volume inescapable ellipsoids contained inside the validity domain of the TS fuzzy model and the smallest inescapable ellipsoids which guarantee a minimum *-norm (upper bound of the 1-norm) of the perturbed system. For every initial point contained in the maximum volume ellipsoid, the closed loop will enter the minimum *-norm ellipsoid after a finite time, and it will remain inside afterwards. Consequently, the designed controllers have a large domain of validity and ensure a small value for the 1-norm of closed loop.
A Fast Evaluation of Initial Configurations in Repeatable Inverse Kinematics for Redundant Manipulators
Authors: Duleba Ignacy , Karcz-Duleba Iwona , Mielczarek Arkadiusz 
Published: October 2018

Abstract
A repeatable inverse kinematic task in robot manipulators consists in finding a loop (cyclic trajectory) in a configuration space, which corresponds to a given loop in a task space. In the robotic literature, an entry configuration to the trajectory is fixed and given by a user. In this paper the assumption is released and a new, indirect method is introduced to find entry configurations generating short trajectories. The method avoids a computationally expensive evaluation of (infinite) many entry configurations for redundant manipulators (for each of them, repeatable inverse kinematics should be run). Some fast-to-compute functions are proposed to evaluate entry configurations and their correlations with resulting lengths of trajectories are computed. It appears that only an original function, based on characteristics of a manipulability subellipsoid, properly distinguishes entry configurations that generate short trajectories. This function can be used either to choose one from a few possible entry configurations or as an optimized function to compute the best initial configuration.
An Exact Geometry–Based Algorithm for Path Planning
Authors: Jafarzadeh Hassan , Fleming Cody H. 
Published: October 2018

Abstract
A novel, exact algorithm is presented to solve the path planning problem that involves finding the shortest collision-free path from a start to a goal point in a two-dimensional environment containing convex and non-convex obstacles. The proposed algorithm, which is called the shortest possible path (SPP) algorithm, constructs a network of lines connecting the vertices of the obstacles and the locations of the start and goal points which is smaller than the network generated by the visibility graph. Then it finds the shortest path from start to goal point within this network. The SPP algorithm generates a safe, smooth and obstacle-free path that has a desired distance from each obstacle. This algorithm is designed for environments that are populated sparsely with convex and nonconvex polygonal obstacles. It has the capability of eliminating some of the polygons that do not play any role in constructing the optimal path. It is proven that the SPP algorithm can find the optimal path in O(nnr2) time, where n is the number of vertices of all polygons and n ̓ is the number of vertices that are considered in constructing the path network (n ̓ ≤ n). The performance of the algorithm is evaluated relative to three major classes of algorithms: heuristic, probabilistic, and classic. Different benchmark scenarios are used to evaluate the performance of the algorithm relative to the first two classes of algorithms: GAMOPP (genetic algorithm for multi-objective path planning), a representative heuristic algorithm, as well as RRT (rapidly-exploring random tree) and PRM (probabilistic road map), two well-known probabilistic algorithms. Time complexity is known for classic algorithms, so the presented algorithm is compared analytically.
Linguistically Defined Clustering of Data
Authors: Leski Jacek M. , Kotas Marian P. 
Published: October 2018

Abstract
This paper introduces a method of data clustering that is based on linguistically specified rules, similar to those applied by a human visually fulfilling a task. The method endeavors to follow these remarkable capabilities of intelligent beings. Even for most complicated data patterns a human is capable of accomplishing the clustering process using relatively simple rules. His/her way of clustering is a sequential search for new structures in the data and new prototypes with the use of the following linguistic rule: search for prototypes in regions of extremely high data densities and immensely far from the previously found ones. Then, after this search has been completed, the respective data have to be assigned to any of the clusters whose nuclei (prototypes) have been found. A human again uses a simple linguistic rule: data from regions with similar densities, which are located exceedingly close to each other, should belong to the same cluster. The goal of this work is to prove experimentally that such simple linguistic rules can result in a clustering method that is competitive with the most effective methods known from the literature on the subject. A linguistic formulation of a validity index for determination of the number of clusters is also presented. Finally, an extensive experimental analysis of benchmark datasets is performed to demonstrate the validity of the clustering approach introduced. Its competitiveness with the state-of-the-art solutions is also shown.
On Hyper–Regularity and Unimodularity of Ore Polynomial Matrices
Authors: Fritzsche Klemens , Rӧbenack Klaus 
Published: October 2018

Abstract
We investigate Ore polynomial matrices, i. e., matrices with polynomial entries in d/dt whose coefficients are meromorphic functions in t and as such constitute a non-commutative ring. In particular, we study the properties of hyper-regularity and unimodularity of such matrices and derive conditions which make it possible to efficiently check for these characteristics. In addition, this approach enables computation of hyper-regular left and right and unimodular inverses.