bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cambios en el consumo aparente de lácteos en hogares con niños menores de 19 años en el Paraguay en el periodo 1997 a 2012
Authors: Bubak Vit , Ramírez Pastore Leticia , Sanabria Marta 
Published: October 2018

Introducción: Los productos lácteos contribuyen significativamente a la ingesta de nutrientes de la población; por lo tanto, entender los cambios en consumo de productos lácteos representa una parte importante del sistema de vigilancia nutricional.
Objetivo: Describir los cambios en los gastos relativos en el consumo aparente de productos lácteos (con y sin auto-producción) y el consumo aparente de calcio en hogares paraguayos con niños menores de 19 años durante el período 1997 a 2012.
Materiales y Métodos: Un análisis descriptivo-analítico de muestras representativas de hogares de la Encuesta Integrada de Hogares (EIH 1997-98) y la Encuesta de Ingresos y Gastos (EIG 2011-12), llevadas a cabo por la Oficina de Estadística, Encuestas y Censos (DGEEC). El análisis se realizó para todos los hogares encuestados, tanto por quintiles de ingresos (Q1-Q5) como por área de residencia (rural/urbana).
Resultados: Tanto los gastos relativos como el consumo aparente (CA) de productos lácteos (incluyendo la auto-producción) aumentaron mínimamente entre 1997 y 2012: los gastos relativos aumentaron del 12,8% al 13% y el CA aumentó de 431cc a 437cc per cápita/día. En términos de productos lácteos individuales, el CA de leche y el CA de leche en polvo disminuyeron (-7.6% y -47.5%), mientras que el CA de queso y el CA de yogur y otros productos lácteos aumentaron (26% y 67.1%). El CA de productos lácteos exhibió cambios diferenciales según el ingreso del hogar, disminuyendo en un 3.1% en los hogares con los ingresos más bajos (Q1) y aumentando en un 6.5% en los hogares con los ingresos más altos (Q5). Del mismo modo, el CA de calcio aumentó marginalmente entre 1997-2012 (de 502 mg a 514 mg per cápita/día), disminuyendo en un 2,6% en los hogares con los ingresos más bajos (Q1) y aumentando en un 7,2% en los hogares con los ingresos más altos (Q5). Tanto en 1997 como en 2012, el CA de productos lácteos y de calcio aumentó con el ingreso del hogar, pero solo los hogares de mayores ingresos (Q5) alcanzaron las recomendaciones diarias de productos lácteos y calcio. La auto-producción contribuyó de manera importante a mejorar la ingesta diaria recomendada de productos lácteos y calcio, especialmente en las zonas rurales.
Conclusiones: El consumo aparente de productos lácteos y de calcio en los hogares paraguayos con niños menores de 19 años cae por debajo de las cantidades diarias recomendadas para todos los hogares con la excepción de los hogares de mayores ingresos.

Correspondencia: Marta Cristina Sanabria Correo: marta.sanabria@gmail.com
Conflicto de interés: Los autores declaran no poseer conflicto de interés.
Recibido: 17/04/2018 Aceptado: 17/07/2018
Rheological parameters of saliva in comparison with taste examination
Authors: Marcinkowska-Gapińska Anna , Linkowska-Świdzińska Kamila , Świdziński Teodor , Surdacka Anna 
Published: October 2018

BACKGROUND: It is generally unknown if taste sensitivity is dependent upon saliva viscosity. The rheological properties of saliva result from many factors and it has been shown to behave as a non-Newtonian fluid whose viscosity decreases with increasing shear rate. Taste sensitivity may be quantitatively assayed by electro-gustometry. OBJECTIVES: The aim of this work was to compare saliva rheological properties, obtained with a rotary-oscillating rheometer, to quantitative measures of taste sensitivity, using electro-gustometry. METHODS: Saliva samples were taken from 27 healthy non-smoking donors – 7 men and 20 women aged 18–65 years (mean age – 37 years). After thresholds of taste sensation were measured, the saliva samples were taken and characterized in terms of their rheological properties and pH. Saliva viscosity was measured in the order of decreasing shear rate in the range 100–0.01 s−1. Viscoelastic properties were examined under constant frequency oscillations (with f = 0.5 Hz) and with decreasing shear effective amplitude [Formula: see text]. RESULTS and CONCLUSIONS: Saliva viscosity was found to decrease with increasing shear rate and varied with time. Analysis of the dependence of the viscosity values of saliva and components of complex viscosity did not show a significant correlation with taste sensation. A dependency of taste sensation on pH could not be discerned due to the narrow range of naturally occurring pH.
Thermo Reversible Hydrogel Based Delivery of Mitomycin C (UGN-101) for Treatment of Upper Tract Urothelial Carcinoma (UTUC)
Authors: Kleinmann Nir , Wirth Gregory , Lin Jeffrey S. , Matin Surena F. , Nativ Ofer , Mayer Gil , Witjes J. Alfred , Shvero Asaf , Chamie Karim , Pantuck Allan J. , Smith Angela , Schoenberg Mark , Malchi Nadav , Hakim Gil , Agmon-Gerstein Yael , Jeshurun-Gutshtat Michal , Klein Ifat , Kopelen Helen , Lerner Seth P. 
Published: October 2018

Background: There is an unmet need for an effective local treatment of upper tract urothelial carcinoma (UTUC). Drug delivery to the pyelocaliceal system and pursuant efficacy of intracavitary therapy is limited by urine production that washes the drug away, shortening dwell time and direct contact with the urothelium. Successful endoscopic management is often dictated by lesion size, grade, and focality. A thermo-reversible hydrogel formulation of Mitomycin C (UGN-101, formerly MitoGel) was developed and has demonstrated the safety and feasibility of increased time of the drug in the pyelocaliceal system resulting in chemoablation of tumors. Objectives: To examine the efficacy and safety of UGN-101 used for chemoablation of UTUC. Methods: There were 22 patients approved for compassionate use treatment at 14 institutions. Six-weekly instillations of UGN-101 were administered via ureteral catheter or percutaneous nephrostomy. Ureteroscopy was performed 2–6 weeks following treatment completion for response determination. Adverse events were recorded throughout treatment. Patients were followed up according to the standard of care of each center. Results: Median age of the cohort was 75 yrs., with 16 (73%) males. Eighteen patients had low-grade (LG) tumors, 2 high-grade (HG), and 2 had indeterminate grade. Median volume of UGN-101 instilled was 13.5cc with median Mitomycin dosage of 54 mg. Eight patients had complete response (36%) including 44% (8/18) of the patients with low grade tumors. Partial responses were observed in 23% and 28% of LG. Two patients had no response (9%) and 1 did not undergo ureteroscopy. Four patients could not complete 6 weeks due to adverse events (pyelonephritis, acute renal failure, pancytopenia, and unstable cardiac condition); 1 patient was diagnosed with a non-urothelial cancer during treatment; and 1 patient died prior to the third instillation due to suspected pulmonary embolus, determined to be unrelated to treatment with UGN-101. Out of the patients who had a complete response, 3 (37.5%) patients are recurrence free from 18–30 months. A total of 83 adverse events were recorded. Of these, 6 events related to UGN-101 were serious (requiring medical intervention), and 23 events related to UGN-101 were not serious. Conclusions: This compassionate use program of UGN-101 demonstrates proof of concept for chemoablation treatment of UTUC. A single arm Phase III multi-center registration trial to treat patients with low-grade low-volume renal pelvis tumors is open and enrolling patients (NCT02793128).
The ICF story: The evolution of a multi-stranded global society
Authors: Taplin D.M.R. 
Published: October 2018

This paper addresses the history of ICF 1969–2017 and the challenges ahead for a new era of ICF 2017–2029. In 1969 ICF was established in Brighton, UK with a governing constitution via the Statutes & Bye-Laws. These Statutes & Bye-Laws are indeed an evolving, living document with progressive revisions followed over the decades since 1969. Many evolutions in developing our now mature ICF culture and modus operandi have occurred over the years. There will be others in the challenging era ahead 2017–2029 via ICF14, ICF15, ICF16 & ICF17 but we might highlight: (1) The Gold & Silver Medals introduced in 2009 at ICF12 as an important extra-statutory evolution of ICF for the benefit of our global brand via AwardCo; (2) The Honour Lectures introduced in 1977 at ICF4 via Ashby/Bilby and followed to the highest standard therefrom; (3) The MoU System to assure the autonomy and independent organization of our quadrennials in the context of the ICF Culture introduced at ICF12 via the Canadian Government and developed for ICF13, ICF14 & ICF15; (4) The Quadrennials Regional Rotation guideline introduced at ICF6 in 1984 to ensure wide global participation; (5) The Interquadrennials Programme initiated in 1983 in Beijing after ICF5 and continued very actively since ICF12 with various ICF regions; (6) The Enlarged Portfolio-Based ExCo introduced at ICF13 for wider representation and “New Blood”; (7) The Enhanced Accreditation of voting Council members to be introduced at ICF14 via NomCo; (8) The Multi-Stranding of the original ICF micro/macro brand from ICF4 and progressively at each quadrennial including geo-physics, biomedical, bio-engineering, non-metallics, computational mechanics, adhesion, nano-scales, sustainabilty, energy, education, politics/society, safer engineering, risk & disaster analysis; (9) The ICF Website and accessibility to all our Proceedings introduced via IGF after ICF12; (10) The Regional Groups in the Far-East, Iberia/Latin America, Africa, India, Australasia, Europe, Canada, Egypt and variously from 1976 onwards originally via Dominique in Compiegne, France and EGF; (11) The Chief Executive-Treasurer role in structured leadership since ICF6; (12) The ICF Culture of friendly, human, transparent, democratic, harmony-oriented – respecting past contributions of “heavy-lifters” via emeritus standing and FICF election – towards Safer, Sustainable Technology for the common good.
Penerapan Analisis SWOT dan Five Forces Porter Sebagai Landasan untuk Merumuskan Strategi Pemasaran dalam Meningkatkan Laba Perusahaan (Studi Pada Tin Panda Collection di Kabupaten Magelang)
Authors: Meftahudin Meftahudin , Putranto Agus , Wijayanti Ratna 
Published: October 2018

Penelitian ini bertujuan untuk mengetahui bagaimana penerapan analisis SWOT dan Porter’s Five Forces Model sebagai landasan untuk merumuskan strategi pemasaran dalam meningkatkan laba perusahaan. Penelitian ini dilakukan pada CV Tin Panda Collection di Kabupaten Magelang Jawa Tengah. Metode analisis yang digunakan adalah dengan metode analisis data kuantitatif dan studi kasus. Penelitian ini menghasilkan bahwa di dalam lingkungan Tin Panda Collection terdapat kekuatan dan kelemahan perusahaan. Kekuatan dari perusahaan antara lain adalah; produk berkualitas tinggi, perusahaan yang memiliki reputasi dan kredibilitas tinggi. Terdapat pula kelemahan dari perusahaan yaitu Tin Panda Collection belum memiliki ijin usaha. Lingkungan eksternal dari Tin Panda Collection yaitu lingkungan industri dan lingkungan jauh. Lingkungan industri meliputi; ancaman pendatang baru, daya tawar pemasok, daya tawar konsumen. Selain itu lingkungan luar perusahaan meliputi; politik, ekonomi, sosial, dan teknologi. Faktor yang paling berdampak terhadap Tin Panda Collection adalah faktor persaingan dengan perusahaan sejenis. Strategi yang digunakan perusahaan saat ini merupakan strategi intensif dengan strategi pengembangan pasar (market development). Strategi ini dilakukan dengan memperkenalkan produk yang sudah ada ke wilayah geografis baru. Sedangkan hasil penelitian lima kekuatan Porter pada Tin Panda Collection bahwa faktor persaingan di dalam industri tinggi, kekuatan tawar-menawar pemasok tinggi, kekuatan tawarmenawar pembeli tinggi. Faktor persaingan di dalam industri tinggi karena pertumbuhan industri yang meningkat, jumlah pesaing yang ada semakin banyak, perusahaan memiliki biaya yang berbeda, dan hambatan keluar tinggi yang menyebabkan kondisi persiangan yang terjadi. Faktor kekuatan tawar-menawar pemasok tinggi karena konsentrasi pemasok tinggi, kemampuan pemasok melakukan integrasi ke arah depan tinggi, dan ketergantungan pemasok dengan industri tinggi. Faktor kekuatan tawar menawar pembeli tinggi karena pembeli memiliki switching cost tinggi terhadap Tin Panda Collection yang mengutamakan kualitas dan informasi yang didapat pembeli tidak dapat membuat pembeli dapat mengontrol harga yang ditawarkan Tin Panda Collection. Faktor ancaman pendatang baru tinggi karena modal yang dibutuhkan tidak besar dan menguntungkan. Hasil evaluasi peluang dan ancaman menggunakan matriks, Tin Panda Collection menunjukkan bahwa respon perusahaan terhadap lingkungan industri berada di atas rata-rata. Artinya Tin Panda Collection bisa memaksimalkan peluang dan mengatasi ancaman dari faktor eksternal.

Kata Kunci: Analisis SWOT, Porter’s Five Forces Model, Strategi pemasaran
Assistance Influence on Labor Pain Level
Authors: Seno Adjie JM , Putri Ruth WR 
Published: October 2018

Objective: To assess assistance influence on labor pain level.
Method: This study was a randomized-clinical, unmasked trial with
concealment by measuring labor pain level in two patients group:
with and without assistance during labor; each group consisted of 36
subjects. Pain intensity were measured using Faces Pain Rating
Scale. Mann-Whitney analysis was done to assess significance of
pain level between two groups.
Result: Majority of patient who were in non-assisted group had very
painful score 50% with mean of VAS 7.38±2.12, meanwhile most of
assisted group complained painful score 44.44%, with mean of VAS
6.11±1.90.
Conclusion: There was significance level of painful score between
non-assisted and assisted subjects x(p
Fetal Fibronectin (fFN) on the Imminent Premature Parturition in Correlation with Incidence of Preterm Labor
Authors: Keman Kusnarman , Nugrahanti Prasetyorini , Supriany Ni Wayan 
Published: October 2018

Objective: To determine the relationship of fFn levels in cervicovaginal
discharge of pregnant women who experience imminent
premature parturition with the incidence of preterm labor.
Method: The study was carried out with Analytic Observational Prospective
Cohort using cervicovaginal discharge of pregnant women
that experienced imminent premature parturition taken from the
delivery room of Obstetrics and Gynecology department dr. Saiful
Anwar Hospital, Malang as well as Bangil Hospital and Ngudi
Waluyo Wlingi Hospital. Statistical analysis was performed using the
Shapiro-Wilk test and comparison test used independent samples t
test for normal data, Mann-Whitney test if not. All analysis used SPSS
for Windows 19.0 software.
Result: Thirty two patient samples was examined, 14 patients
(43.75%) were primigravida and 18 patients (52.56%) is multigravida.
17 of these patients (53.13%) experienced aterm labor and
15 patients (46.87%) experienced preterm labor. Mann-Whitney
test of the mean fFN levels between the aterm group (13.01 ± 7.57
ng/ml) and the preterm group (56.29 ± 27.77 ng/ml) showed a significant
difference (p-value = 0.000 > 0.05). Moreover, Spearman’s
Rho correlation test also showed a strong correlation between fFN
level and incidence of preterm labor (R = 0.797, p < 0.05).
Conclusion: fFN levels is significantly increase in cervicovaginal discharge
from pregnant women with imminent premature parturition
who experience preterm labor than pregnant women who experience
aterm labor. Therefore, this result suggests that fFN has potential
ability to become useful modality in preterm labor diagnosis.
[Indones J Obstet Gynecol 2016; 1: 8-14]
Keywords: cervicovaginal discharge, fFN, imminent premature parturition,
preterm labor
Curcumin Administration on Proliferation and Apoptosis Index in Complete Hydatidiform Mole CellCulture
Authors: Nurseta Tatit , Irwanto Yahya , Imelda Imelda 
Published: October 2018

Objective: To investigate that curcumin can decreasing proliferation
index and increasing apoptosis index.
Method: This is an experimental non-blinded study with post test
control group design, at Cell/Tissue Culture Laboratory at Medical
Faculty of Brawijaya University. This study using CHM trophoblastic
cell culture from CHM curettage patient, exposed by several doses of
curcumin, 0, 50, 100, 200, 400 and 800 μM, then examined by the
method of MTT proliferation index and apoptosis index by the
method of labeling DNA fragmentation TUNEL system. Data analyzed
by one-way ANOVA.
Result: In this study, the mean values obtained decrease in proliferation
index with increasing doses of curcumin. Giving a dose of
200 μM curcumin, 400 μM and 800 μM proved highly significant
(p = 0.001) reduced proliferation index compared with the control
and curcumin dose of 50 μM and 100 μM. From this research shows
that there are significant differences in the increase of apoptosis index
(p = 0.001) between the control group with curcumin dose
group 200 μM, 400 μM and 800 μM. But there was no significant
difference in the mean of apoptosis index among the three dose
groups.
Conclusion: Giving curcumin dose of 200 μM can decreasing the
proliferation index and increasing the apoptosis index increases in
CHM trophoblastic cell culture.
[Indones J Obstet Gynecol 2016; 1: 37-41]
Keywords: apoptosis index, curcumin, proliferation index
Theurapeutic Response of Neoadjuvant Chemotherapy between Platinum and Ifosfamide Combination and Platinum, Vincristine and Bleomycin Combination in Cervical Carcinoma Stage IB2
Authors: Nuryanto Kartiwa H , Purbadi Sigit 
Published: October 2018

Objective: To evaluate the theurapeutic response and acute toxicity
of neoadjuvant chemotherapy between the combination of Platinum
and Ifosfamide, and the combination of Platinum, Vincristine and
Bleomycin in Cervical Carcinoma Stage IB2 and then continued with
radical hysterectomy and pelvic lymphadenectomy.
Method: Thirteen samples received neoadjuvant chemotherapy of
Platinum and Ifosfamide and 17 samples received neoadjuvant chemotherapy
of Platinum, Vincristine and Bleomycin, after receiving
the neoadjuvant chemotherapy, clinically complete response samples
underwent radical hysterectomy and pelvic lymphadenectomy
(PI VS PVB = 3 VS 1). Histopathology examination was performed to
evaluate the presence of malignant viable cells at the cervix, pelvic
lymph node metastasis and parametrium metastasis. Acute toxicity
evaluation was performed based on gastrointestinal, genitourinarius
and hematology sign and symptom.
Result: Theurapeutic response of PI is 1.12 higher than PVB
(p>0.05). Subanalysis of group response of PI is 1.962 higher than
PVB. PI and PVB have the same risk to have pelvic lymph node metastasis,
but not parametrial metastasis. There were no differences
in terms of the risk of gastrointestinal, genitourinarius and hematologic
toxicity between PI and PVB.
Conclusion: There was no statistical difference in clinical and
pathological response, and also in acute toxicity between the two
combination (p>0.05).
[Indones J Obstet Gynecol 2016; 1: 47-51]
Keywords: acute toxicity, cervical carcinoma stage IB2, neoadjuvant
chemotherapy, response
Female Sexual Function after Vaginal Delivery with Episiotomy and Cesarean Section
Authors: Jembawan I Made W 
Published: October 2018

Objective: To determine the difference of sexual function after vaginal
delivery with episiotomy and cesarean section in Sanglah Hospital,
Denpasar.
Method: This research was conducted using cross sectional method.
Sample was collected using consecutive sampling, starting from October 2011-September 2012. Our sample consists of 86 women, 43 post-episiotomy and 43 post-cesarean section. Sexual function was assessed using FSFI (Female Sexual Function Index). Total score was analyzed using independent t-test and difference of sexual function was tested using Chi-square, with significance level p0.05). There was no significant difference between the two groups in term of sexual arousal and lubrication, with p-value 0.160 and 0.67, respectively. However, we found significant difference in other domains, namely desire (p=0.014), orgasm (p=0.045), satisfaction (p=0.018), pain (p=0.02), and total FSFI score (p=0.006). Sexual dysfunction was found in 18.60% of the episiotomy group and 2.33% of the cesarean section group, with p=0.030.
Conclusion: Female sexual dysfunction was found to be significantly
different between women post vaginal delivery with episiotomy and
women who had cesarean section.
[Indones J Obstet Gynecol 2014; 4: 199-203]
Keywords: cesarean section, episiotomy, female sexual function
Prevalence of Postpartum Anxiety and Depression after Intrapartum Oxytocin
Authors: Valentine Grace , Kayika I Putu G 
Published: October 2018

Objective: To know the prevalence of postpartum anxiety and depression
in patients who received intrapartum oxytocin.
Method: Across-sectional observational study was conducted in Dr.
Cipto Mangunkusumo hospital. Observation used Edinburgh Postnatal
Depression scale and Beck Anxiety Inventory before delivery
day, on the first and fourteenth day of postpartum.
Result: Of 112 patients, we found the prevalence of mild and moderate
anxiety were 94.6% and 5.4%. There were no anxiety women
before delivery and on the first day of postpartum. The prevalence
of mild and moderate anxiety on the fourteenth day of postpartum
were 83% and 16.9%. There was no severe anxiety found at those
time. On the other hand, the prevalence of postpartum depression
on the first and fourteenth day of postpartum were 31.3% and
32.1%. There was no association between exogenous oxytocin and
postpartum anxiety also depression. In multivariate analysis, we
found that women with low self image were more prone to postpartum
anxiety (OR 0.16, 95% CI 0.06-0.46). Meanwhile, postpartum
depression was associated significantly to self image (OR 0.17, 95%
CI 0.07-0.83), low income (OR 10.35, 95% CI 1.72-62.45) and pregnancy
plan (OR 0.17, 95% CI 0.06-0.53)
Conclusion: The patients who received intrapartum oxytocin are
more prevalent to have mild anxiety. The prevalence of depression
before delivery day, on the first and fourteenth day of postpartum
are similar. In statistic, there is no relationship between intrapartum
oxytocin administration and postpartum anxiety or depression.
[Indones J Obstet Gynecol 2016; 4-2: 59-63]
Keywords: anxiety, depression, oxytocin intrapartum, postpartum
The Outcomes of Primary Debulking Surgery and Neoadjuvant Chemotherapy in Advanced Ovarian Cancer
Authors: Rinaldy Dino , Andrijono Andrijono , Sutrisna Bambang 
Published: October 2018

Objective: To compare the outcomes and survival rate of primary
debulking surgery with neoadjuvant chemotherapy.
Method: We selected advanced ovarian cancer patients from medical
records. Subjects were allocated into groups of primary debulking
surgery and neoajuvant chemotherapy by considering the inclusion
and exclusion criteria. We analyzed the data using T test,
Fisher’s exact, and chi-square. The survival rate was presented in
Kaplan Meier curve, whereas the significance was tested with Logrank.
We managed the data using STRATA software version 12.
Result: We obtained 32 cases of primary debulking surgery group
and 20 cases of the neoadjuvant chemotherapy group. Most of the
subjects (44.2%) were 40-49 years old and 80.8% had delivered
more than twice. The mean value of Ca-125 at admission was
3,594.8 u/ml (range 66.6 to 73,000 u/ml). Total of 31 subjects
showed the serous histologic type (59.6%). There was no association
between primary debulking surgery and neoadjuvant chemotherapy
for the parameter of operative time, blood loss, organs injury,
ICU stay, and hospital stay (p>0.05). Primary debulking surgery
had a survival rate similar to neoadjuvant chemotherapy group
(p=0.95).
Conclusion: The perioperative outcomes of advanced ovarian cancer
patients has similar result between primary debulking surgery
and neoadjuvant chemotherapy. Primary debulking surgery has a
survival rate similar to neoadjuvant chemotherapy group.
[Indones J Obstet Gynecol 2016; 4-2: 111-115]
Keywords: advanced ovarian cancer, neoadjuvant chemotherapy,
primary debulking surgery