bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hydrous magnesium-rich magma genesis at the top of the lower mantle
Authors: Nakajima Ayano , Sakamaki Tatsuya , Kawazoe Takaaki , Suzuki Akio 
Published: May 2019

AbstractSeveral igneous activities occur on the surface of the Earth, including island arcs, mid-ocean ridges and hot spots. Based on geophysical observations, melting phenomena in the interior also occur at the asthenosphere’s top and the upper mantle’s bottom. Additionally, a seismological low-velocity anomaly was observed at the top of the lower mantle that may result from mantle melting due to dehydration decomposition of ringwoodite to bridgmanite and ferropericlase with a downward flow. However, the corresponding high-pressure experimental data are too poor to understand the melting phenomena under the lower mantle condition. Herein, we conducted hydrous peridotite melting experiments at pressures from 23.5 to 26 GPa and at temperatures from 1300 to 1600 °C for demonstrating the melt composition and the gravitational stability of magma at the top of the lower mantle. The melt had a SiO2-poor and MgO-rich composition, which is completely different than that of dry peridotite melting experiments. Compared with the seismological lower mantle, the experimental melt is gravitationally lighter; thus, a similar melt could be observed as seismological low-velocity zone at the lower mantle’s top. The generated magma plays as a filter of down-welling mantle and can contribute to a formation of a silicate perovskitic lower mantle.
Long non-coding RNA SPRY4-IT1 promotes epithelial–mesenchymal transition of cervical cancer by regulating the miR-101-3p/ZEB1 axis
Authors: Fan Ming-Jun , Zou Yong-Hui , He Peng-Juan , Zhang Shuai , Sun Xiao-Mei , Li Chang-Zhong 
Published: May 2019

Abstract
Background: Emerging evidences have indicated that long non-coding RNAs (LncRNAs) play vital roles in cancer development and progression. Previous studies have suggested that overexpression of SPRY4 intronic transcript 1 (SPRY4-IT1) predicates poor prognosis and promotes tumor progress in cervical cancer (CC). However, the underlying mechanism of SPRY4-IT1 in CC remains unknown. The aim of the present study is to evaluate the function and mechanism of SPRY4-IT1 in CC.
Methods: SPRY4-IT1 was detected by quantitative PCR. Wound-healing assay and Transwell assay were performed to detect cell migration and invasion, respectively. Western blotting assays were used to analyze the protein expression of E-cadherin, N-cadherin and vimentin. Tumor xenografts experiments were performed to detect the effect of SPRY4-IT1 in vivo. Dual luciferase reporter assay was used to investigate potential molecular mechanism of SPRY4-IT1 in CC cells.
Results: SPRY4-IT1 was up-regulated in CC cell lines. Knockdown of SPRY4-IT1 significantly inhibited CC cells migration and invasion in vitro and in vivo. Moreover, knockdown of SPRY4-IT1 significantly suppressed the epithelial–mesenchymal transition (EMT) of CC by increased E-cadherin expression and decreased the N-cadherin and vimentin expression. Mechanically, SPRY4-IT1 could directly bind to miR-101-3p and effectively act as a competing endogenous RNA (ceRNA) for miR-101-3p to regulate the expression of the target gene ZEB1.
Conclusions: Our findings indicate that the SPYR4-IT1/miR-101-3p/ZEB1 axis contributes to CC migration and invasion, which may provide novel insights into the function of lncRNA-driven tumorigenesis of CC.
Autologous activated platelet-rich plasma injection into adult human ovary tissue: molecular mechanism, analysis, and discussion of reproductive response
Authors: Sills E. Scott , Wood Samuel H. 
Published: May 2019

AbstractIn clinical infertility practice, one intractable problem is low (or absent) ovarian reserve which in turn reflects the natural oocyte depletion associated with advancing maternal age. The number of available eggs has been generally thought to be finite and strictly limited, an entrenched and largely unchallenged tenet dating back more than 50 years. In the past decade, it has been suggested that renewable ovarian germline stem cells (GSCs) exist in adults, and that such cells may be utilized as an oocyte source for women seeking to extend fertility. Currently, the issue of whether mammalian females possess such a population of renewable GSCs remains unsettled. The topic is complex and even agreement on a definitive approach to verify the process of ‘ovarian rescue’ or ‘re-potentiation’ has been elusive. Similarities have been noted between wound healing and ovarian tissue repair following capsule rupture at ovulation. In addition, molecular signaling events which might be necessary to reverse the effects of reproductive ageing seem congruent with changes occurring in tissue injury responses elsewhere. Recently, clinical experience with such a technique based on autologous activated platelet-rich plasma (PRP) treatment of the adult human ovary has been reported. This review summarizes the present state of understanding of the interaction of platelet-derived growth factors with adult ovarian tissue, and the outcome of human reproductive potential following PRP treatment.
Autism Spectrum Disorder and Sibling Relationships: Exploring Implications for Intervention Using a Family Systems Framework
Authors: Wright Bridget M. , Benigno Joann P. 
Published: May 2019

Purpose
There is currently a very limited scope of research in the field of speech-language pathology on sibling involvement in the treatment of children with autism spectrum disorder (ASD). Principles of family systems theory (FST) recognize the interrelatedness and dynamic nature of the family unit, making it a relevant and useful guiding framework for future research and practice on sibling involvement in intervention.

Method
In this article, core principles of FST are reviewed, followed by the state of research related to sibling relationships in ASD, and roles of typically developing siblings and siblings with ASD in intervention programs. Implications for adopting an FST framework as well as considerations and future directions in this area of research and clinical practice are discussed.

Results
According to the principles of FST on the inclusion of siblings in treatment, there are several considerations to be made at the level of the child with ASD, the sibling(s), and the family unit. Factors such as developmental level, communication status, and areas of strength, challenge, and interest are key features of the children and family that will need to be addressed in order to promote positive sibling involvement and family functioning.

Conclusions
The development of family-centered sibling intervention programs for individuals with ASD is an area of research that warrants further exploration. With the guidance of the FST framework, researchers and clinicians can work to develop innovative interventions that consider the unique characteristics of each family to optimize outcomes at the levels of each individual, the sibling relationship, and the family as a unit.
Interventions Targeting Expressive Communication in Adults With Autism Spectrum Disorders: A Systematic Review
Authors: Wilson Kaitlyn P. , Steinbrenner Jessica R. , Kalandadze Tamar , Handler Lara 
Published: May 2019

Purpose
The aims of this systematic review are to (a) synthesize the literature on interventions targeting expressive communication in adults with autism spectrum disorder and (b) evaluate the effectiveness of the interventions.

Method
The literature search resulted in 7,196 articles. The research team used 2 reviewers and consensus for title/abstract review, full-text review, and quality review. To be included, studies had to (a) include at least 1 adult (18 years of age and above) with an autism spectrum disorder; (b) examine an intervention, treatment, or model of care; (c) provide outcome data related to expressive communication modalities/domains; (d) be experimental or quasi-experimental; and (e) be published in English. Twenty-two studies (14 single-case design and 8 group design), with a total of 256 participants and varied interventions and outcome variables, met criteria for inclusion. Effect sizes are presented for group design studies, and visual analysis results are outlined for single-case design studies.

Results
Examination of treatment effects in the included studies showed positive effects, overall; however, there was great variability between studies. Single-case design studies showed evidence of functional relations in all but 1 study, with most showing medium to large effects, as well as maintenance and generalization of gains. Group design studies showed a wide range of effects from near-zero to large effects. Differences in intervention strategies and durations, as well as in participant characteristics and outcome measures, presented barriers to aggregation.

Conclusions
This review highlights the need for increased high-quality research examining interventions targeting expressive communication in adults with autism spectrum disorder and also pinpoints interventions with potential for future study and use in this population.
Musician and Nonmusician Hearing Aid Setting Preferences for Music and Speech Stimuli
Authors: D'Onofrio Kristen L. , Gifford René H. , Ricketts Todd A. 
Published: May 2019

Purpose
The purpose of this study was to evaluate potential group differences between musicians and nonmusicians in their self-adjusted (SA) gain and compression settings for both music and speech stimuli. Speech recognition, sound quality, and strength of preference for the SA settings and the original prescriptive (National Acoustic Laboratories–Nonlinear 2 [NAL-NL2]) settings were also compared.

Method

Participants included 12 musician (
M
= 60 years) and 12 nonmusician (
M
= 55 years) adult hearing aid users with mild–moderate hearing loss, on average. Self-adjustments were made to hearing aid gain and compression settings for 2 music stimuli and a speech stimulus. Speech recognition in quiet and noise, sound quality for 6 dimensions (clarity, pleasantness, naturalness, fullness, brightness, and overall impression), and strength of preference ratings using paired comparisons were then assessed at both the NAL-NL2 settings and the participants' SA settings.

Results
On average, self-adjustments made by both groups were quite small (< 5 dB for gain and < 0.5 for compression ratio). Furthermore, SA changes to gain and compression ratio were not significantly different for musicians versus nonmusicians or for music versus speech. Finally, speech perception performance and sound quality ratings did not differ for the SA settings versus the NAL-NL2 settings, with the exception of the naturalness sound quality dimension.

Conclusions
These data suggest that a gain–frequency response specific to musicians and/or music inputs may not be necessary. Thus, current, validated prescriptive methods continue to be well supported as an appropriate starting place for listeners with mild–moderate hearing loss using open hearing aid fittings.
Bidirectional marx DC–DC converter for offshore wind farm application
Authors: Alagab Samir Milad , Tennakoon Sarath , Gould Chris 
Published: May 2019

The bidirectional DC–DC converter explained here is based on the Marx principle and is capable of achieving step‐up and step‐down voltage transformations at kV level and is able to handle MW‐level power transfers in both directions. The main features of this topology are the absence of a high‐frequency transformer, reduced weight, volume, and soft switching to reduce the switching losses. In the boost mode, five capacitors are charged in parallel and discharged in series to achieve the step‐up action, and in the buck mode, the converse action takes place. The operating principle is explained, and the steady‐state analysis of the converter is given. Matlab/Simulink simulation of a 50 MW converter, interfacing 6 kV, and 30 kV systems supports and validates the theoretical analysis, enables positive supporting the conclusions to be made.
The 3D secular dynamics of radial-velocity-detected planetary systems
Authors: Volpi Mara , Roisin Arnaud , Libert Anne-Sophie 
Published: May 2019

Aims. To date, more than 600 multi-planetary systems have been discovered. Due to the limitations of the detection methods, our knowledge of the systems is usually far from complete. In particular, for planetary systems discovered with the radial velocity (RV) technique, the inclinations of the orbital planes, and thus the mutual inclinations and planetary masses, are unknown. Our work aims to constrain the spatial configuration of several RV-detected extrasolar systems that are not in a mean-motion resonance.
Methods. Through an analytical study based on a first-order secular Hamiltonian expansion and numerical explorations performed with a chaos detector, we identified ranges of values for the orbital inclinations and the mutual inclinations, which ensure the long-term stability of the system. Our results were validated by comparison with n-body simulations, showing the accuracy of our analytical approach up to high mutual inclinations (∼70 ° −80°).
Results. We find that, given the current estimations for the parameters of the selected systems, long-term regular evolution of the spatial configurations is observed, for all the systems, (i) at low mutual inclinations (typically less than 35°) and (ii) at higher mutual inclinations, preferentially if the system is in a Lidov-Kozai resonance. Indeed, a rapid destabilisation of highly mutually inclined orbits is commonly observed, due to the significant chaos that develops around the stability islands of the Lidov-Kozai resonance. The extent of the Lidov-Kozai resonant region is discussed for ten planetary systems (HD 11506, HD 12661, HD 134987, HD 142, HD 154857, HD 164922, HD 169830, HD 207832, HD 4732, and HD 74156).
Photospheric and coronal magnetic fields in six magnetographs
Authors: Virtanen Ilpo , Mursula Kalevi 
Published: May 2019

Context. Solar photospheric magnetic fields have been observed since the 1950s and calibrated digital data are available from the 1970s onwards. Synoptic maps of the photospheric magnetic field are widely used in solar research, especially in the modeling of the solar corona and solar wind, and in studies of space weather and space climate. Magnetic flux density of the solar corona is a key parameter for heliospheric physics.
Aims. The observed photospheric magnetic flux depends on the instrument and data processing used, which is a major problem for long-term studies. Here we scale the different observations of the photospheric field to the same absolute level and form a uniform record of coronal magnetic flux since the 1970s.
Methods. We use a recently suggested method of harmonic scaling, which scales any pair of synoptic observations of any resolution to the same level. After scaling, we use the Potential Field Source Surface (PFSS) model to calculate the scaled magnetic field at various altitudes from photosphere to coronal source surface.
Results. Harmonic scaling gives effective, latitudinally dependent scaling factors, which vary over the solar cycle. When scaling low-resolution data to high-resolution data, effective scaling factors are typically largest at low latitudes in the ascending phase of solar cycle and smallest for unipolar polar fields around solar minima. The harmonic scaling method used here allows for the observations of the different data sets to be scaled to the same level and the scaled unsigned coronal flux densities agree very well with each other. We also find that scaled coronal magnetic fields show a slightly different solar cycle variation from that of the nonscaled fields.
Adequate Structured Inpatient Diabetes Intervention in People With Type 1 Diabetes Improves Metabolic Control and Frequency of Hypoglycaemia
Authors: Burghardt Katharina , Müller Ulrich Alfons , Müller Nicolle , Kloos Christof , Kramer Guido , Jörgens Viktor , Kuniss Nadine 
Published: May 2019

Abstract
Objective Several studies evaluated inpatient diabetes teaching and treatment programmes (DTTP) in diabetes type 1 (DM1) many years ago, but in these studies insulin treatment was not yet intensified before the DTTP. Today, most patients are already on intensified insulin treatment before entering a DTTP. The aim of this trial was to evaluate the outcome one year after participation in an inpatient intervention including a DTTP in a longitudinal study.
Methods 109 patients participated in an inpatient intervention in 2014. All individuals were invited to participate in an outpatient follow-up visit after one year.
Results Ninety participants (52.2% female, age 48.0 y, diabetes duration 19.1 y, 31.1% CSII, HbA1c 7.9% / 63.3 mmol/mol) were followed-up after 1.2±0.3 y [1 died, 18 declined / were not available]. 83 / 90 individuals participated to optimise diabetes therapy, 7 / 90 had newly-diagnosed DM1. In the optimisation group, HbA1c decreased by 0.4% (p=0.009) without change of insulin dose (54 IU/day before and after) or BMI (26 kg/m2 before and after). In people with baseline HbA1c ≥7.5% (n=26 / 83), HbA1c decreased by 0.9%. The frequency of severe hypoglycaemia decreased from 0.22 to 0.05 events / year (p=0.045). In people with frequent non severe hypoglycaemia (n=8), events decreased from 4.5±2.0 to 2.8±0.9 / week (p=0.358). Systolic (−6.5 mmHg, p=0.035) and diastolic (−3.4 mmHg, p=0.003) blood pressure improved without change of number of antihypertensive medication (1.9±2.1 vs. 1.8±2.0, p=0.288).
Conclusions In people with DM1, metabolic control improved after the inpatient intervention without increasing insulin dosage or BMI. The inpatient intervention remains effective to substantially improve metabolic control under the present circumstances of care.
A Bottom-Up Approach to Encouraging Sustained User Adoption of a Secure Text Messaging Application
Authors: Tsega Surafel , Kalra Angeli , Sevilla Cesar , Cho Hyung 
Published: May 2019

Background Inpatient providers are increasingly utilizing alternative communication modalities outside what has traditionally been used, including short messaging service text messaging and application-based chat tools. Text messaging that meets the recommendations of the Joint Commission (“secure text messaging”) allows for the communication of sensitive patient information through an encrypted platform.
Objective In this quality initiative utilizing the Plan-Do-Study-Act (PDSA) model, we attempted two rollout designs to maximize user adoption of a secure text messaging application.
Methods Our institution launched a secure text messaging application (Cureatr) using a top-down approach during the first PDSA cycle, defined as communication and outreach through department chairs and administrative leaders throughout the hospital. After inadequate user adoption, we transitioned to a bottom-up approach in the second PDSA cycle, defined as direct communication and engagement with end users. This campaign targeted the hospital medicine and inpatient social work department, and used discharge planning as a use case to encourage adoption.
Results Over a 6-month period, we observed an increase in active users in the hospital medicine department (7.5 unique users per month to 29 users during the first and second PDSA cycles, p < 0.01). Additionally, we saw an increase in messages sent and received by the medicine (687 messages on average per month and 7,367 messages per month in each respective PDSA cycle, p < 0.01) and social work departments (350 messages on average per month and 6,083 messages during the first and second PDSA cycle, p < 0.01). We did not observe a significant change in active users or messages sent in the surgery department, which did not participate in the second PDSA cycle.
Conclusion We believe that a bottom-up approach is important to introducing mobile applications to the inpatient setting and can contribute to sustained user adoption.
PROMIS Physical Function Correlates with KOOS, JR in Patients with Knee Pain
Authors: Kortlever Joost T. P. , Leyton-Mange Andrea , Keulen Mark H. F. , Liu Tiffany C. , Janssen Stein J. , Bozic Kevin J. , Schultz W. Randall , Koenig Karl M. 
Published: May 2019

AbstractUsing Patient-Reported Outcomes Measurement Information System Physical Function (PROMIS PF) computerized adaptive test instead of the Knee injury and Osteoarthritis Outcome Score for Joint Replacement (KOOS, JR) could reduce question burden for patients with knee pain. We aimed to prospectively determine the correlation between PROMIS PF and KOOS, JR to assess whether PROMIS PF could be a useful alternative measure for both research and clinical care of patients with knee pain. This was a cross-sectional study of 88 patients. We assessed the correlation between PROMIS PF and KOOS, JR using a Pearson's correlation test. Two multivariable linear regression models were used to determine the amount of variation explained by various patient-level factors. There was a strong correlation between PROMIS PF and KOOS, JR (r = 0.74, p < 0.001). KOOS, JR was an independent predictor of PROMIS PF when controlling for patient-level factors (β 0.26; p < 0.001). The results of this study support the idea of using PROMIS PF in place of joint-specific measures such as KOOS, JR for clinical care of patients with knee pain. The level of evidence for this study is Level III.
Arthroscopic All-Inside Repair of Tear of the Anterior Horn of Discoid Lateral Meniscus
Authors: Muniandy Moganadass , Rajagopal Sivalingam , Tahir Siti 
Published: May 2019

AbstractThe anterior horn of lateral meniscus tear is usually repaired using outside-in technique. Although easy to perform, it was associated with several complications which may alter the outcome of the surgery. Here, we present a case of an adolescent girl presented with incomplete discoid lateral meniscus accompanied by tear of anterior horn. The tear was repaired using all-inside technique without any implants. We described the surgical technique and discussed the rationale.
Ability of plant pathogenic fungi Gibberella fujikuroi and Fusarium commune to react with airborne methyl jasmonate
Authors: Masimbula Rishni , Oki Katsunari , Shibata Hiroki , Osawa Hisashi , Kondo Norio , Takahashi Kosaku , Matsuura Hideyuki 
Published: May 2019

ABSTRACT
The pathogenic fungi Gibberella fujikuroi and Fusarium commune produce jasmonic acid. The application of volatile deuterium-labeled methyl jasmonate increased the amount of nonlabeled JA present in G. fujikuroi and F. commune. These results indicate that the fungi have the ability to react with airborne methyl jasmonate in a manner similar to a plant.
Confronting Epistemological Racism, Decolonizing Scholarly Knowledge: Race and Gender in Applied Linguistics
Authors: Kubota Ryuko 
Published: May 2019

Abstract
Recent scholarship in sociolinguistics and language education has examined how race and language intersect each other and how racism influences linguistic and educational practices. While racism is often conceptualized in terms of individual and institutional injustices, a critical examination of another form of racism—epistemological racism—problematizes how racial inequalities influence our knowledge production and consumption in academe. Highlighting the importance of the intersectional nature of identity categories, this conceptual article aims to draw scholars’ attention on how epistemological racism marginalizes and erases the knowledge produced by scholars in the Global South, women scholars of color, and other minoritized groups. In today’s neoliberal culture of competition, scholars of color are compelled to become complicit with white Euro-American hegemonic knowledge, further perpetuating the hegemony of white knowledge while marginalizing women scholars of color. Valorizing non-European knowledge and collectivity as an alternative framework also risks essentialism and male hegemony. Conversely, the ethics promoted by black feminism emphasizes a personal ethical commitment to antiracism. Epistemological antiracism invites scholars to validate alternative theories, rethink our citation practices, and develop critical reflexivity and accountability.