bluuebunny/crossref_metadata_2025_split huggingface dataset:
Continuous Use of Fiber Optics-Enabled Coiled Tubing Used to Accelerate the Optimization of Completions Aimed at Improved Recovery and Reduced Cost of Development
Authors: Natareno Nestor , Thelen Michael , Charbonneau Jennifer , Sahdev Neha , Cook Peter 
Published: January 2019

Abstract
Continuous improvement in completions designs leading to an increased return on asset development is one of the primary focuses of operating companies. To continue driving towards this goal, an operator looked to continuously optimize completions designs in their acreage in Bakken, North Dakota. There were two parallel paths taken to a) reduce CAPEX on wells (optimizing completions costs) and b) optimize completions designs towards increased recovery. The challenge with the design changes and validation was the time for evaluation. One of primary objectives of this campaign discussed in this paper was to reduce the "reaction time", and be able to make improvements to completions designs in a timely manner
Fiber optics was identified as a technology that could help achieve the campaign's optimization and continuous improvement goals. Coiled tubing-(CT) deployed fiber was run after fracturing treatment in wells to identify fracture initiation points (FIPs). Using FIPs as a proxy for completion effectiveness enables more rapid treatment evaluation than waiting months to use production volumes for the same purpose, the fundamental assumption being that more FIPs ultimately leads to higher production rates. Treatment evaluation data helped the operator understand the effectiveness of various completion designs and make step changes in design for incremental improvement. This analytics campaign is ongoing and treatment evaluation has been performed for more than 20 wells. Treatment evaluation is typically performed in the same CT run as post-fracturing cleanout, reducing the incremental cost of the data acquisition and improving operational efficiency.
The operator was able to achieve project goals using fiber-optics technology. Key findings: Reaction time for completions design changes evaluation changed from about 6 months historically to 1 month by using coiled tubing-deployed fiber optics, which meant faster improvements and better realized returnsUp to 25% increase in production was achievedUp to 8% reduction in capital for completions of the wells was realizedMultiple design changes could be evaluated along a single lateral.
Fiber-optics technology was uniquely used to accelerate the learning curve by reducing the time required to evaluate the effectiveness of completion designs. Evaluating multiple wells created a large, statistically relevant, dataset which has boosted confidence in implementing completions changes.
An Eagle Ford Case Study: Improving an Infill Well Completion Through Optimized Refracturing Treatment of the Offset Parent Wells
Authors: Garza Mary , Baumbach Joshua , Prosser James , Pettigrew Spencer , Elvig Kirsten 
Published: January 2019

Abstract
This case study reviews Noble Energy's completion design, execution, and results of an Eagle Ford infill well B3 and the refracturing (refrac) treatments pumped on the direct offsets referred to in this paper as wells A1 and A2. The refrac stimulations were planned to serve the joint purpose of frac hit protection of the existing parent wells' reserves and re-pressurization of depleted zones to improve the performance of the infill child well. Both chemical diversion and mechanical diversion pods were utilized on the bullhead style refrac to optimize lateral placement of fracturing fluid and proppant.
The A1 refrac was pumped first with a larger job size of proppant, water, and diversion material. The A2 refrac, pumped second, was half the size of the A1. Instantaneous shut-in pressure (ISIP) and diversion pressure response data was captured at each stage for both wells. Infill well B3 was completed last with normal plug-and-perf operations and the optimum job size of the time. The child well B3 production will be compared to offset wells with no depletion risk as well as to a 2014 vintage infill (Y3) well that was completed with no refrac on the direct offsets (X1 and X2).
The A1 refrac data showed a gradual trend of increasing ISIP and treating pressure throughout the job indicating a more uniform stimulation of the lateral. There is a sustained production uplift resulting in a 36% improvement in estimated ultimate recovery (EUR). The A2 refrac data showed anomalous ISIP and pressure spikes mid-way through the job indicating the stimulation was not accessing the entire lateral. This blockage downhole was caused by being too aggressive with the concentration of pods pumped per stage. Since the A2 was not effectively re-pressurized, there was negligible change to EUR when the well was returned to production. In comparing the two refracs, we concluded that a larger job (increased proppant, fluid, and diversion) with less concentrated but more frequent diversion drops will increase lateral coverage and more effectively protect the parent well reserves.
The surface treating pressures of the infill B3 indicate new rock was stimulated and initial production results trend with offset well production of the area showing no impact from depletion. Contrasting this with the prior infill Y3 completed with no refracs on parent wells, the Y3 has lower initial production (IP) rates and EUR when compared to its offset wells showing an obvious impact from depletion. Additionally, the refrac'd parent well A1 saw an improvement in EUR while the non-refrac'd parent X1 saw EUR degradation. In conclusion, pumping optimized refracs on the offset parent wells will both protect parent well reserves and improve the performance of the child well.
Internalization of Tolerance Values in Islamic Education
Authors: Nugroho Puspo 
Published: January 2019

The purpose of this paper is to know the internalization process of religious tolerance values such as tauhid, rahmah, musawah in educational institutions. This study took place in the SMP Muhammadiyah Salatiga, the Junior High School, which using a qualitative approach. The results of this study are that first, to put tolerance values into the curriculum, second, to develop vertical relationships in Allah SWT and horizontal fellow humans, third, to emphasize the implementation of tolerance values in the daily lives of students in realizing Islam rahmatan lil alamin, Fourth, the teacher gives examples of tolerance behavior in the learning process.AbstrakTujuan tulisan ini ingin mengetahui proses internallisasi nilai-nilai toleransi beragama seperti tauhid, rahmah, musawah di lembaga pendidikan. Penelitian ini mengambil lokasi di Sekolah Menengah Pertama Muhammadiyah Salatiga dengan menggunakan pendekatan kualitatif. Hasil penelitian ini adalah pertama memasukkan nilai-nilai toleransi ke dalam kurikulum, kedua : membangun hubungan vertikal pada Allah SWT dan horizontal sesama manusia, ketiga: menekankan pelaksanaan nilai-nilai toleransi dalam kehidupan sehari-hari siswa dalam mewujudkan Islam rahmatan lil alamin. Ke empat: guru memberi contoh prilaku toleransi dalam proses pembelajaran.
The Growth of Learning Enthusiasm at the Emeyodere Muslim Minority Education Institution in West Papua
Authors: Wekke Ismail Suardi , Ruaidah Fitri , Wardi Moh. 
Published: January 2019

The purpose of this study was to find out what factors could trigger the enthusiasm of the Emeyodere foundation students. This study uses a qualitative descriptive research method. The results showed that first, the leadership factor of the foundation, the foundation aim was to elevating the Kokoda tribe from educational backwardness. Second, motivation factor. Third, aid factor, the foundation provides assistance or donations such as books, stationery for every semester, school uniforms for disadvantaged students, and supplementary meals every two weeks.AbstrakTujuan penelitian ini adalah untuk mengetahui faktor-faktor apa saja yang dapat memicu semangat peserta didik yayasan Emeyodere. Penelitian ini menggunakan metode penelitian deskriptif kualitatif. Hasil penelitian menunjukkan bahwa pertama, Faktor kepemimpinan yayasan, yayasan ini didirikan dengan tujuan untuk mengangkat derajat suku Kokoda dari keterbelakangan pendidikan. Kedua, faktor motivasi, ketiga, faktor bantuan, pihak yayasan memberikan bantuan atau sumbangan berupa buku-buku dan alat tulis pada setiap semester, seragam sekolah bagi peserta didik yang kurang mampu, dan makanan tambahan setiap dua minggu sekali.
College Students’ Perception about the Implementation of Democratic and Humanist Learning Model in State Islamic Institute (IAIN) Sultan Amai Gorontalo
Authors: Asiah.T Siti , Anwar Herson 
Published: January 2019

This research aims to analyse the perception of students of Islamic Education Management Study Program at Faculty of Teacher Training and Education, Islamic State University (IAIN) Sultan Amai Gorontalo about the implementation of democratic and humanist learning model. The sample used in the research was 98 respondents. The data analysis technique used was descriptive statistic by using Weighted Means Score (WMS) formula. The research result about student perception showed that lecturers at Islamic Education Management Study Program had already been applied democratic and humanist learning model perfectly in the interactive learning condition. To realize a democratic and humanist learning model, lecturer figure is needed that has the knowledge and ability to develop a model of democratic and humanist learning. AbstrakPenelitian ini bertujuan untuk mengkaji dan menganalisis persepsi mahasiswa Prodi Manajemen Pendidikan Islam Fakultas Ilmu Tarbiyah dan Keguruan IAIN Sultan Amai Gorontalo tentang penerapan model pembelajaran yang demokratis dan humanis. Jumlah sampel adalah 98 responden. Teknik analisis data menggunakan statistik deskriptif dengan rumus Weighted Means Score (WMS). Hasil penelitian mengenai persepsi mahasiswa menunjukkan bahwa model pembelajaran demokratis dan humanis sudah diterapkan dengan baik dalam suasana pembelajaran yang interaksi dan interaktif. Untuk mewujudkan model pembelajaran yang demokratis dan humanis, diperlukan sosok dosen yang memiliki pengetahuan dan kemampuan untuk mengembangkan model pembelajaran demokratis dan humanis
Model of Religious Culture Education and Humanity
Authors: Abdullah Muhammad Luthfi , Syahri Akhmad 
Published: January 2019

This study aims to find out how the model of religious cultural education to create human character. This study uses a qualitative method. The research subjects were students at the Darut Tauhid Islamic boarding school in Bandung. The results of the study show that there are 8 (eight) religious cultures implemented in education and become a spirit to form human values, namely TSP (Resistant to littering, storing garbage in its place, picking up garbage insha Allah blessing); Bebaskomiba (Messing, Wet-Drying, Dirty-Cleaning, Leaning, Dangerous)); three M, five K, profit concept, five S, five don't, seven B.AbstrakPenelitian ini bertujuan untuk mengetahui bagaimana model pendidikan budaya berbasis agama untuk membentuk nilai-nilai kemanusiaan. Penelitian ini menggunakan metode kualitatif. Subjek penelitiannya adalah mahasiswa di pesantren Darut Tauhid Bandung. Hasil penelitian menunjukkan bahwa ada 8 (delapan) budaya agama yang diimplementasikan dalam pendidikan dan menjadi semangat untuk membentuk nilai-nilai kemanusiaan yaitu TSP (Tahan dari buang sampah sembarangan, Simpan sampah pada tempatnya,Pungut sampah insya Allah berkah); Bebaskomiba (Berantakan-rapikan, Basah-keringkan, Kotor-bersihkan, Miring-luruskan, Bahaya-amankan); tiga M, lima K, konsep untung, lima S, lima jangan, tujuh B. Kata Kunci: Model Pendidikan; Budaya Agama; Nilai Kemanusiaan Islam; Program Pesantren Mahasiswa; Daarut Tauhiid
Analysis Study of Parental Choice of Education in The Millenial Era
Authors: Fauzi Ahmad , BR Rosyadi , Baharun Hasan 
Published: January 2019

This article discusses parents' choices about the model of Islamic education in the millennial era. This study uses the library method. The results showed that parents had several criteria in determining the choice of educational models in the millennial era, namely a). schools that provide a lot of religious material b). combining religion and science, c). giving reinforcement to monotheism, d). madrasas that have vision, mission with good management. E). madrasas that have the same status as public schools. AbstrakArtikel ini membahas pilihan orang tua tentang model pendidikan Islam di era milenial. Penelitian ini menggunakan metode kepustakaan. Hasil penelitian menunjukkan bahwa orangtua memiliki beberapa kriteria dalam menentukan pilihan model pendidikan di era millennial yaitu a). sekolah yang banyak memberikan materi agama b). mengkombinasikan agama dan sains, c). memberikan penguatan pada tauhid, d). madrasah yang memiliki visi, misi dengan pengelolaan manajemen yang baik. E). madrasah yang memiliki status yang sama dengan sekolah umum
The Cultivation of Tolerance Value in Madrasah through Tahfidh Hadits
Authors: Musyafiq Ahmad 
Published: January 2019

This article will analyze the content and learning process of the tahfidh hadith in Integrated Madrasah Ibtidaiyah (MIT) Nurul Islam Ngaliyan Semarang related to the cultivation of tolerance values. This study uses content analysis and in-depth interviews. The results of this study are that first, most of the contents of the tahfid hadith package contain ghairu mahdlah (social) worship which reaches 83%, in which there is a tolerance value, while the hadith about worship is 17%. Second, the tahfidh learning process uses a variety of methods, namely writing, reading, memorizing, translating and monitoring the application of the values contained in the hadith in everyday life. AbstrakArtikel ini akan menganalisa isi dan proses pembelajaran tahfidh hadis di Madrasah Ibtidaiyah Terpadu (MIT) Nurul Islam Ngaliyan Semarang terkait dengan penanaman nilai-nilai toleransi. Penelitian ini menggunakan analisis isi dan wawancara mendalam. Hasilnya adalah bahwa pertama, sebagian besar isi paket hadis tahfidh memuat ibadah ghairu mahdlah (sosial) yang mencapai 83%, yang di dalamnya terdapat nilai toleransi, sedangkan hadits tentang ibadah mahdhah 17%. Kedua, Proses pembelajaran tahfidh hadits menggunakan berbagai variasi metode yaitu menulis, membaca, menghafal, menerjemah dan pemantauan penerapan nilai-nilai yang terkandung dalam hadits dalam kehidupan sehari-hari .
Albumin Based Nanoparticles for Detection of Pancreatic Cancer Cells
Authors: Karaca Nursenem , Ünlüer Özlem Biçen 
Published: January 2019

Background:Molecular imaging of cancer cells using effective drug targeting systems are most interested research area in recent years. Albumin protein is a soluble and most abundant protein in circulatory system. It has a ligand-binding function and acts as a transport protein. Researchers are interested in developing albumin based nanostructured specific anti-tumor drugs in cancer therapy. Pancreatic cancer treatment or drug design for targeted pancreatic cancer cell has great importance due to it has a high mortality rate comparing other cancer types.Objective:In this article, our goal is to develop new targeting nanoparticles based on the conjugation of albumin and Hyaluronic Acid (HA) for pancreatic cancer cells.Method:In this article, we proposed a new technique for conjugation of albumin (BSA) and HA in nano formation. Firstly, cationic BSA is synthesized. Then, BSA-HA conjugation is obtained by interacted cationic BSA with 1000 ppm HA. Secondly, nano BSA-HA particles and nano BSA particles were synthesized according to AmiNoAcid Decorated and Light Underpinning Conjugation Approach (ANADOLUCA) method which provides a special cross-linking strategy for biomolecules using ruthenium-based amino acid monomer haptens. After characterization studies, in vitro cytotoxic activity of synthesized nano BSA-HA particles were determined for PANC-1 ATCC® CRL146 cells.Results:According to the data, nano BSA and nano BSA-HA particles synthesized uniquely using special ruthenium-based amino acid decorated cross-linking agent, (MATyr)2-Ru-(MATyr)2.based on ANDOLUCA method. Characterization results showed that there was not any change in protein folding structures during nano formation process. In addition, nano protein particles gained fluorescence feature. When interacting synthesized nano BSA and nano BSA-HA particles with pancreatic cells, it was found that BSA nanoparticles were usually around cells and membranes, but BSA-HA nanoparticles were identified around the cells, in the cytoplasm inside the cell, and next to the cell nucleus. So, nano BSA-HA particles could be used as cancer cell imaging agent for PANC-1 ATCC® CRL146 cells.Conclusion:The satisfactory conclusion of this study is that synthesized nano BSA-HA particles are fundamental materials for targeting pancreatic cancer cells due to HA receptors located on pancreatic cancer cells and imaging agents due to fluorescence feature of the BSA-HA nanoparticles.</P>
Human Mesenchymal Stem Cell-derived Exosomes Reduce Ischemia/Reperfusion Injury by the Inhibitions of Apoptosis and Autophagy
Authors: Jiang Xiaofei , Lew Kar-Sheng , Chen Qiying , Richards Arthur M. , Wang Peipei 
Published: January 2019

Background:
Human mesenchymal stem cell-derived exosomes (hMSC-Exo) have been shown to
reduce ischemia/reperfusion injury (I/R) in multiple models. I/R-induced apoptosis or autophagy play important
roles in cell death. However, little or no reports demonstrate any roles of hMSC-Exo in this regards. Objective:
To test the hypothesis that the inhibition of I/R-induced apoptosis and autophagy play a pivotal role in the cardioprotection
of hMSC-Exo.

Methods:
Myoblast H9c2 cells and isolated rat hearts underwent hypoxia/re-oxygenate (H/R) or ischemia/
reperfusion (I/R) respectively. H9c2 were treated with 1.0 μg/ml Exo, in comparison with 3-MA or rapamycin
(Rapa), a known anti- or pro-autophagic agent respectively. Hearts were treated with 0.5, 1.0 and 2.0 μg/ml
Exo for 20 min in the beginning of reperfusion. Cell viability, WST assay, LDH release, Annexin-V staining
apoptosis assay and GFP-LC3 labeled autophagosomes formation, cardiac function and Western blot were measured.

Results:
Exo significantly reduced H/R injury as indicated by increased cell viability and reduced LDH and apoptosis.
3-MA, while Rapa, showed increased or decreased protective effects. Rapa-induced injury was partially
blocked by Exo. Exo decreased LC3-II/I ratio and increased p62, inhibited autophagosome formation, an indication
of autophagy inhibition. In isolated heart, Exo increased cardiac functional recovery and reduced LDH release
in I/R. Bcl-2 was significantly upregulated by Exo but not 3-MA. Exo downregulated Traf6 and upregulated
mTORC1/p-4eBP1.

Conclusion:
Exo reduce I/R-induced apoptosis and autophagy. Up-regulation of Bcl-2 is the cross-talk between
these two processes. The down-regulation of Traf6 and activation of mTORC1 are additional mechanisms in the
inhibition of apoptosis and autophagy.
Role of 2-Dimensional Autocorrelation Descriptors in Predicting Antimalarial Activity of Artemisinin and its Aanalogues: A QSAR Study
Authors: Kalra Sourav , Joshi Gaurav , Kumar Raj , Munshi Anjana 
Published: January 2019

Background:
Malaria, one of the World’s biggest billers’ is on the schedule for biomedical
research and public health policies. The introduction of the artemisinin, a Chinese traditional drug from
Artemisia annua is a revolution in the treatment of malaria. Artemisinin-based combination treatment
(ACT) is considered to be the best strategy for uncomplicated Falciparum malaria. The presence of
1,2,4-trioxane system in artemisinin is responsible for its antimalarial activity.

Methods:
In this study, twenty-nine analogues of artemisinin were taken into account for QSAR studies
along with artemisinin. The most active analogue of artemisinin 21 was energy minimized. All the structures
were prepared from the active conformer 21 and energy was minimized to the stable state using
MMFF94 force field using ChemBioDraw-12. Genetic Algorithm is used to decide the descriptors best
required for the model generation. The test set and training set division were done by using hierarchal
clustering module available with NCSS statistical software.

Results and Conclusion:
The antimalarial activity of the artemisinin and its substituted analogues has
been analyzed through the multiple linear regression (MLR) using various physiochemical and structural
descriptors obtained from PADEL software. The models were prepared using the Sigma Plot version 11.
The calculated 2D autocorrelation descriptors and the MLR model suggest that artemisinin and its
analogues hold the scope in the optimization of antimalarial activity.
Social Determinants Associated with Tuberculosis Mortality in a General Hospital in Mexico
Authors: Ábrego-Fernández Juan Ángel , Laniado-Laborín Rafael 
Published: January 2019

Background:Most TB deaths can be prevented with timely diagnosis and appropriate treatment. In fact, millions of people are diagnosed and treated successfully every year, avoiding millions of deaths. However, globally, there are still huge gaps in detection and treatment.Objective:To identify the social determinants associated with mortality due to TB in a general hospital in Mexico.Methodology:All patients admitted with a diagnosis of pulmonary tuberculosis to the Emergency Department of a hospital in Mexico were included during a 10-month period. At the end of the study, the condition of discharge of all cases was obtained from the electronic database of the State Tuberculosis Program.Results:One-hundred and twenty-four patients with tuberculosis were included in the sample. Thirty-eight patients (30.6%) died during their hospital stay and eleven (8.9%) died outside the hospital after their discharge, for a total of 49 (39.5%) deaths. Of the 29 patients with HIV/AIDS, 12 died (41.3%). Logistic regression analysis showed that older age, imprisonment, and previous tuberculosis were significant predictors of mortality.Conclusion:The mortality of tuberculosis patients diagnosed in HGT is very high, mainly because the diagnosis is established at the hospital level, which implies a late diagnosis.
Dysfunction of Magnocellular/dorsal Processing Stream in Schizophrenia
Authors: Chieffi Sergio 
Published: January 2019

Background:Patients with schizophrenia show not only cognitive, but also perceptual deficits. Perceptual deficits may affect different sensory modalities. Among these, the impairment of visual information processing is of particular relevance as demonstrated by the high incidence of visual disturbances. In recent years, the study of neurophysiological mechanisms that underlie visuo-perceptual, -spatial and -motor disorders in schizophrenia has increasingly attracted the interest of researchers.Objective:The study aims to review the existent literature on magnocellular/dorsal (occipitoparietal) visual processing stream impairment in schizophrenia. The impairment of relatively early stages of visual information processing was examined using experimental paradigms such as backward masking, contrast sensitivity, contour detection, and perceptual closure. The deficits of late processing stages were detected by examining visuo-spatial and -motor abilities.Results:Neurophysiological and behavioral studies support the existence of deficits in the processing of visual information along the magnocellular/dorsal pathway. These deficits appear to affect both early and late stages of visual information processing.Conclusion:The existence of disturbances in the early processing of visual information along the magnocellular/dorsal pathway is strongly supported by neurophysiological and behavioral observations. Early magnocellular dysfunction may provide a substrate for late dorsal processing impairment as well as higher-level cognition deficits.