bluuebunny/crossref_metadata_2025_split huggingface dataset:
Orthotopic and heterotopic murine models of pancreatic cancer and their different responses to FOLFIRINOX chemotherapy
Authors: Erstad Derek J. , Sojoodi Mozhdeh , Taylor Martin S. , Ghoshal Sarani , Razavi Allen A. , Graham-O'Regan Katherine A. , Bardeesy Nabeel , Ferrone Cristina R. , Lanuti Michael , Caravan Peter , Tanabe Kenneth K. , Fuchs Bryan C. 
Published: June 2018

ABSTRACT
Syngeneic, immunocompetent allograft tumor models recapitulate important aspects of the tumor microenvironment and have short tumor latency with predictable growth kinetics, making them useful for trialing novel therapeutics. Here, we describe surgical techniques for orthotopic and heterotopic pancreatic ductal adenocarcinoma (PDAC) tumor implantation and characterize phenotypes based on implantation site.
Mice (n=8 per group) were implanted with 104 cells in the pancreas or flank. Hy15549 and Han4.13 cell lines were derived from primary murine PDAC (Ptf1-Cre; LSL-KRAS-G12D; Trp53 Lox/+) on C57BL/6 and FVB strains, respectively. Single-cell suspension and solid tumor implants were compared. Tumors were treated with two intravenous doses of FOLFIRINOX and responses evaluated.
All mice developed pancreatic tumors within 7 days. Orthotopic tumors grew faster and larger than heterotopic tumors. By 3 weeks, orthotopic mice began losing weight, and showed declines in body condition requiring euthanasia starting at 4 weeks. Single-cell injection into the pancreas had near 100% engraftment, but solid tumor implant engraftment was ∼50% and was associated with growth restriction. Orthotopic tumors were significantly more responsive to intravenous FOLFIRINOX compared with heterotopic tumors, with greater reductions in size and increased apoptosis. Heterotopic tumors were more desmoplastic and hypovascular. However, drug uptake into tumor tissue was equivalent regardless of tumor location or degree of fibrosis, indicating that microenvironment differences between heterotopic and orthotopic tumors influenced response to therapy.
Our results show that orthotopic and heterotopic allograft locations confer unique microenvironments that influence growth kinetics, desmoplastic response and angiogenesis. Tumor location influences chemosensitivity to FOLFIRINOX and should inform future preclinical trials.
This article has an associated First Person interview with the first author of the paper.
T.Rex, Bowie and Foucault: Early glam rock’s influence on European youth culture
Authors: Olding Christine 
Published: June 2018

Abstract
This article explores the impact and influence of early glamrock artists T.Rex (Marc Bolan) and David Bowie on the early 1970s’ European youth culture. Focusing on their lyrical representation, vocal presentation and visual theatrical performance techniques in the songs ‘Baby Strange’ and ‘Life on Mars?’, I analyse the artists’ impact through their relation to the theory of the madman put forth by Michel Foucault. Despite both Bolan and Bowie’s taboo physical and lyrical presentation, their music and performances present the truth of the youth culture concerning two of the main themes in glam music: sexual exploration and exploration of self. It is the artists’ representations of these themes that allow members of the early 1970s’ European youth culture to recognize their own sense of identity and self-realization as something that is beyond the taboo. T.Rex (Bolan) and David Bowie present their messages in a way that allows the younger generation to recognize that they are not alone and perhaps they are not the ‘madmen’ after all.
An unfinished mourning: Kenneth Lonergan’s Manchester by the Sea (2016)
Authors: Angeli Silvia 
Published: June 2018

Abstract
This article considers the notions of grief and mourning in Kenneth Lonergan’s Manchester by the Sea (2016). The analysis centres on three moments characterized by the coexistence of two opposite states: numbness and an abundance of feelings; immobility and mobility; infidelity and fidelity. To understand each moment, I draw on three philosophical approaches to mourning elaborated by Ralph Waldo Emerson, Roland Barthes and Jacques Derrida. In the first moment, I posit an analogy between the grief experienced by the film’s protagonist Lee and the grief described by Emerson in his essay ‘Experience’. In both cases, grief takes the form of numbness that only masks an abundance of feelings. In the second moment, I apply Barthes’s account of psychic immobility after his mother’s death to the film protagonist’s experience. In the third moment, I analyse Lee’s mourning in relation to Derrida’s concept of ‘possible’ (or ‘successful’) and unsuccessful mourning. Finally, this analysis turns to the question of the bereaved’s loyalty (to the departed, to those who survived and to one’s own grief). Together, these three perspectives reveal a complex, nuanced portrayal of mourning in Manchester by the Sea, which departs from the widespread Freudian understanding of grief and mourning.
Rekruitmen Karang Scleractinia di Perairan Pulau Lembata (Recruitment of Scleractinian Corals at Lembata Island Waters)
Authors: Bachtiar Imam , Abrar Muhammad , Budiyanto Agus 
Published: June 2018

Potensi rekruitmen karang sangat penting di dalam pengelolaan terumbu karang, karena potensi pemulihan terumbu karang tergantung pada rekruitmen karang. Penelitian rekruitmen karang Scleractinia dilakukan di perairan Pulau Lembata, Nusa Tenggara Timur, pada bulan Juli 2011. Penelitian ini bertujuan untuk mengetahui keanekaragaman dan kelimpahan rekruit (anakan) karang. Hasil penelitian menunjukkan bahwa Acroporidae, Pocilloporidae, dan Poritidae merupakan tiga famili karang yang mempunyai kontribusi terbesar pada rekruitmen karang di perairan Lembata. Komposisi genus karang pada stasiun penelitian di Laut Flores (Pulau Lapan, Pulau Watupeni, Pulau Wuku) berbeda dari komposisi genus karang di stasiun perairan selat sekitar Pulau Lembata dan Laut Sawu. Ketiga stasiun penelitian di Laut Flores juga mempunyai kelimpahan rekruit yang lebih tinggi dari lokasi lainnya. Kata kunci: karang, rekruitmen, Lembata, komposisi, kelimpahan Potential recruitment of Scleractinian corals is very important in coral reef management, since coral reef recovery is very dependent on coral recruitment. Study on coral recruitment was conducted in Pulau Lembata waters, Nusa Tenggara Timur, on July 2011. Objectives of the study were to determine taxa (family and genera) diversity and abundance of coral recruits. Results showed that coral families of Acroporidae, Pocilloporidae, and Poritidae had highest contribution to the whole coral recruitment. Study locations in the Flores Sea (Pulau Lapan, Pulau Watupeni, Pulau Wuku) showed genera composition that is different from other study locations. The three islands in the Flores Sea also had significantly higher recruit abundance than those in other locations. Key words: coral, recruitment, Lembata, composition, abundance
Impact of Physical Performance and Anthropometric Characteristics on Serve Velocity in Elite Junior Tennis Players
Authors: Fett Janina , Ulbricht Alexander , Ferrauti Alexander 
Published: June 2018

Abstract
Fett, J, Ulbricht, A, and Ferrauti, A. Impact of physical performance and anthropometric characteristics on serve velocity in elite junior tennis players. J Strength Cond Res 34(1): 192–202, 2020—This study aimed to investigate the impact of physical performance components and anthropometric characteristics on serve velocity (SV) in elite junior tennis players depending on the sex and age group. A sample of the best 1,019 (male = 625, female = 394) junior squad tennis players of the German Tennis Federation participated in the study involving complex anthropometric measurements (body height, body mass, sitting height, and arm span) and physical tests (e.g., SV, medicine ball throws [MBTs], hand grip strength, push-ups, back extension, countermovement jumps [CMJs], horizontal jumps, 20-m sprint, and tennis-specific endurance). Of all the anthropometric and physical characteristics analyzed, the MBTs (r = 0.49–0.60♂; r = 0.20–0.60♀), hand grip strength (r = 0.43–0.59♂; r = 0.27–0.37♀), arm span (r = 0.37–0.56♂; r = 0.24–0.36♀), body height (r = 0.31–0.52♂; r = 0.26–0.38♀), and body mass (r = 0.44–0.57♂; r = 0.35–0.39♀) were particularly closely correlated with SV. The results of the multiple regression analysis indicated that the combination of selected predictors (e.g., MBTs, grip strength, arm span, and body mass) explained 41–66% of the variance in SV of boys and 19–45%, respectively, for girls. The results reinforce that service speed is dependent on physical abilities and anthropometric characteristics but also strongly on additional factors (i.e., technical components). In particular, the upper-body power/strength is important to the junior players' service, especially in athletes with a greater body height and arm span (i.e., biomechanical advantages), whereas purely lower-body power (e.g., CMJ) is less important. To this effect, talent identification and intervention programs focusing on the specific requirements are recommended.
An Assessment of Running Power as a Training Metric for Elite and Recreational Runners
Authors: Aubry Rachel L. , Power Geoff A. , Burr Jamie F. 
Published: June 2018

Abstract
Aubry, RL, Power, GA, and Burr, JF. An assessment of running power as a training metric for elite and recreational runners. J Strength Cond Res 32(8): 2258–2264, 2018—Power, as a testing and training metric to quantify effort, is well accepted in cycling, but is not commonly used in running to quantify effort or performance. This study sought to investigate a novel training tool, the Stryd Running Power Meter, and the applicability of running power (and its individually calculated run mechanics) to be a useful surrogate of metabolic demand (V̇o
2), across different running surfaces, within different caliber runners. Recreational (n = 13) and elite (n = 11) runners completed a test assessing V̇o
2 at 3 different paces, while wearing a Stryd Power Meter on both an indoor treadmill and an outdoor track, to investigate relationships between estimated running power and metabolic demand. A weak but significant relationship was found between running power and V̇o
2 considering all participants as a homogenous group (r = 0.29); however, when assessing each population individually, no significant relationship was found. Examination of the individual mechanical components of power revealed that a correlative decrease in V̇o
2 representing improved efficiency was associated with decreased ground contact time (r = 0.56), vertical oscillation (r = 0.46), and cadence (r = 0.37) on the treadmill in the recreational group only. Although metabolic demand differed significantly between surfaces at most speeds, run power did not accurately reflect differences in metabolic cost between the 2 surfaces. Running power, calculated via the Stryd Power Meter, is not sufficiently accurate as a surrogate of metabolic demand, particularly in the elite population. However, in a recreational population, this training tool could be useful for feedback on several running dynamics known to influence running economy.
Workloads of Competitive Surfing: Work-to-Relief Ratios, Surf-Break Demands, and Updated Analysis
Authors: Farley Oliver R.L. , Secomb Josh L. , Raymond Ellen R. , Lundgren Lina E. , Ferrier Brendon K. , Abbiss Chris R. , Sheppard Jeremy M. 
Published: June 2018

Abstract
Farley, ORL, Secomb, JL, Raymond, ER, Lundgren, LE, Ferrier, BK, Abbiss, CR, and Sheppard, JM. Workloads of competitive surfing: work-to-relief ratios, surf-break demands, and updated analysis. J Strength Cond Res 32(10): 2939–2948, 2018—The study provides an in-depth descriptive and quantitative time-motion analysis of competitive surfing, using Global Positioning System (GPS) units and video synchronization, which serves to extend upon the results of Farley, Harris, and Kilding (Journal of Strength and Conditioning Research, 26, 7 [2012]). In addition, comparisons between locations and surfers competing in the same heats were performed. Global Positioning System and video data were collected from 41 male competitive surfers (23.2 ± 6.1 years, 71 ± 10.3 kg, 177.2 ± 6.4 cm) participating in 3 professional domestic surfing events, with competitive heats of 20-minute duration. Fifty data sets were analyzed across the 3 competitions, with velocities and distances covered, proportion of time spent performing various surfing activities, and total work-to-relief ratio determined. Results revealed surfers paddled 44% of the total time, followed by stationary periods (42%). Surfers performed at a significantly (p ≤ 0.05) higher work-to-relief ratio (1.7:1) at the beach-break (an exposed beach) compared with point-break 1 and 2 (waves breaking around a rocky point). Point-breaks 1 and 2 had longer continuous durations of paddling, with significantly longer rides at point-break 1 over the beach-break (p ≤ 0.01) and point-break 2 (p ≤ 0.01). The average maximal speed (24.8 km·h−1) from point-break 2 was significantly faster than point-break 1 (p ≤ 0.01) and beach-break (p ≤ 0.05). This information should influence surfing drills and conditioning methods to prepare these athletes for the disparate demands, such as training for a point-break competition involving longer durations of continuous paddling and short, high-intensity workloads for a beach-break.
Nutritional Considerations for the Female Vegan Athlete
Authors: Schoenfeld Melody L. 
Published: June 2018

ABSTRACT
According to the top trends in prepared foods 2017 market research report, the number of U.S. consumers following a vegan lifestyle has jumped from 1% of the population in 2014 to 6% of the population in 2017. It is therefore a reality that many female athletes may be considering or following a vegan lifestyle. Although macronutrient and micronutrient needs can certainly be met on a meat-free diet, understanding how to execute a nutritionally sound vegan diet is key. This article will discuss the vegan diet, as it pertains to the female athlete.
Chronique du livre
Authors: Aubin Stéphane , Joyal André , Nenkam Serge Rodrigue 
Published: June 2018

Pouget, J. (2010). Intégrer et manager la génération Y, Vuibert, 208 p.
Gagnon, C. (sous la dir.) (2012). Territoires durables en devenir, Québec, Presses de l’Université du Québec/Numérique, 255 p.
Hamdouch, A., Depret, M.-H. et Tanguy, C. (sous la dir.) (2012). Mondialisation et résilience des territoires : Trajectoires, dynamiques d’acteurs et expériences, Québec, Presses de l’Université du Québec, 318 p.
Cervical lymphangioma of adult: Case report and current treatment
Authors: Cadena Piñeros Enrique , Rojas Andres Felipe 
Published: June 2018

Introducción: Los tumores quísticos del cuello son inusuales en los adultos. Sin embargo, se pueden encontrar metástasis a ganglios, quistes branquiales, quistes tiroglosos, linfangiomas, entre otros. Clínicamente, estos últimos son masas blandas de crecimiento lento que se localizan en diferentes espacios del cuello.Reporte de caso: Se reporta un caso de linfangioma en una mujer de 36 años, quien consultó por masa lateral derecha del cuello con evolución de 20 días sin síntomas sistémicos asociados. A pesar de que la recaída es frecuente, la paciente fue tratada con cirugía exitosa sin evidencia de recidiva durante 12 meses de seguimiento. Discusión: Cuando se presentan en niños, los tumores quísticos del cuello se pueden convertir en urgencias quirúrgicas debido a obstrucción de la vía aérea; no obstante, en los adultos solo producen deformidad de contorno y rara vez requieren una intervención apremiante, lo que permite conductas conservadoras como la observación, el drenaje repetido o la escleroterapia. Esta última puede hacerse con el OK-432 (Picibanil); sin embargo, la cirugía es una buena opción de tratamiento sin estar exenta de complicaciones.Conclusión: Se realizó revisión de las diferentes opciones de tratamiento y se concluyó que la resección quirúrgica de los linfagiomas continúa siendo la opción más adecuada para el manejo de esta compleja lesión del cuello.
Prevalence and Risk Factors of Hepatitis C Virus (HCV) in Tehsil Batkhela District Malakand, KPK, Pakistan
Authors: Khan Mudassir , Khan Shahrukh , Haider Shohra , Jalil Fazal , Jamal Muhsin , Ahmad Aziz 
Published: June 2018

Background: Prevalence of Hepatitis C viral infection and its major risk factors has been found out in population of Batkhela, Khyber Pakhtunkhwa, Pakistan by taking number of volunteers from the interested area. HCV prevalence has not been researched in recent time here in this area, so that’s why we contributed.
Materials and Methods: Ab rapid test cassette serum/plasma (USA) kit has been used for the mentioned purpose following by ELISA and finally PCR to find out active infection of virus. ICT positive individuals were reconfirmed by ELISA and then ELISA positive samples were carefully investigated by RT-PCR for Hepatitis C Virus.
Results: The study population was of 770 volunteers belonging to the mentioned area of research, 453 males and 317 females. The overall prevalence was found to be 5.32% of HCV in Batkhela. This prevalence ratio was 3.12% in males and 2.20 % in females. 3rd generation ELISA was used to refine ICT positive samples which showed that 37 of the ICT positive samples had antibodies detected by ELISA. To find out active HCV infection, ELISA positive samples were refined by real time PCR which showed 2.98% of prevalence of active HCV infection in Batkhela based on HCV RNA in their blood.
Principle Conclusion: Overall prevalence was found 5.32%, contaminated reused syringes and blades at Barbour’s shop, blood transfusion, surgical operations and unhygienic food in stalls etc were found significant risk factors for acquiring HCV infection. Body weakness and pale yellow skin color was common symptom in HCV positive volunteers. Safe sexual activities, blood screening before donation and sterilizing surgical equipment’s can protect us from Hepatitis C Virus.
Presentación
Authors: Hederich Christian 
Published: June 2018

Asistimos, durante los últimos años, a un inusitado incremento de la violencia en el interior de la institución escolar. Fenómenos como el bullying o matoneo, el cobro de cuentas entre estudiantes, el pandillismo, las amenazas a estudiantes y docentes, y el porte y uso de armas, se han hecho bastante frecuentes en nuestras escuelas y colegios, y han ido de la mano con el aumento en los índices de suicidio en niños y jóvenes.
Diversidad cultural e implicaciones en la enseñanza de las ciencias: reflexiones y avances
Authors: Molina Andrade Adela , Martínez Rivera Carmen Alicia , Mosquera Suárez Carlos Javier , Mojica Rios Lyda 
Published: June 2018

El presente artículo se configuró a partir de la versión del marco teórico y los antecedentes del proyecto de investigación “Concepciones de los profesores de ciencias sobre la diversidad cultural y sus implicaciones en la enseñanza”1. Se inicia con una idea de diversidad cultural, apoyada en Mauss, Douglas y Bruner. Luego se argumenta cómo el problema de la diversidad implica emergencias y complejidades que incluyen lo político, la configuración de la identidad y la memoria cultural, que actúan como un mecanismo de recuerdo y olvido. En esta dialéctica, se describen algunos trazos de nuestra propia constitución cultural. Con este marco se caracterizan posibles relaciones entre diversidad cultural y educación. Así, se pueden destacar varias reflexiones, entendidas como un abreboca para iniciar la discusión en torno a lo educativo y en relación con lo diverso, apareciendo entonces, notas para comprender la homogeneización en la educación y las relaciones entre diversidad cultural, educación y enseñanza de las ciencias. La polaridad descrita se discute en el marco de la educación en ciencias como campo de investigación, ya que es tal vez en el que los debates sobre homogenización y la diversidad se manifiestan con gran “efervescencia”, dado que la ciencia encarna uno de los pilares más importantes de la modernidad.
En busca de la escuela del siglo XXI: ¿Puede darnos la pista la Escuela Nueva de Colombia?
Authors: Shiefelbein Ernesto , Vera Rodrigo , Aranda Humberto , Vargas Zoila , Corco Víctor 
Published: June 2018

Mejorar la calidad de la educación es ahora el principal desafío de los países de América Latina y del Caribe, pero puede ser una tarea muy difícil de llevar a cabo con éxito. Los indicadores de calidad de la educación básica han detectado la existencia de serios problemas de calidad en la mayoría de los sistemas educativos de América Latina. El que la educación sea de baja calidad merece una atención prioritaria de parte de los gobiernos, ya que tiene consecuencias, en muchas actividades y es especialmente crítica, ahora que el crecimiento económico y la democracia demandan personas con mejor formación. Sin embargo, muchos intentos por mejorarla no han tenido éxito. La escuela tradicional donde un profesor enseña a un alumno promedio (método frontal de enseñanza) enfrenta una cantidad de problemas y limita la posibilidad de ofrecer una educación de buena calidad adecuada a las exigencias del desarrollo económico. Sólo una revisión profunda de la educación básica, sobre la base de un nuevo modelo de escuela y métodos de enseñanza renovadas, permitiría lograr la calidad requerida para el siglo XXI.
Análisis de la distribución espacial de equipamientos educativos (0–16 años) en Extremadura a escala de detalle
Authors: Nieto Masot Ana , Márquez Segovia Nieves 
Published: June 2018

La educación supone uno de los derechos universales más esenciales, por ello es necesario que se garantice su accesibilidad a toda la población y en especial a las zonas más desfavorecidas. Por ello, en este trabajo se estudiarán los recursos educativos en edades tempranas (Educación Infantil, Primaria y Educación Secundaria Obligatoria) en una región eminentemente rural y con baja densidad demográfica como es el caso de Extremadura para comprobar si existe una adecuada distribución de los mismos. Se han utilizado técnicas de análisis espaciales y de correlación de variables, mediante Sistemas de Información Geográfica, para comprobar si la distribución a los servicios educativos es la adecuada.
Modelling streamflow response to climate change in data-scarce White Volta River basin of West Africa using a semi-distributed hydrologic model
Authors: Abubakari Sulemana , Dong Xiaohua , Su Bob , Hu Xiaonong , Liu Ji , Li Yinghai , Peng Tao , Ma Haibo , Wang Kai , Xu Shijin 
Published: June 2018

Abstract
This study uses high resolution Climate Forecast System Reanalysis (CFSR), SWAT and two IPCC climate change (CC) scenarios (A1B and B1) combined with two general circulation models (GCMs) (HADCM3 and MPEH5) to evaluate impact of CC on streamflow in the White Volta basin of West Africa. The evaluation criteria (R2 and NSE &gt; 0.70 and PBIAS within ±25%) during calibration and validation showed good simulation of the basin hydrology. Using average streamflow from 1979 to 2008 as a baseline, there were uncertainties over the sign of variation of annual streamflow in the 2020s. Annually, streamflow change is projected to be within −4.00% to +13.00% in the 2020s and +3.00% to +16.00% in the 2050s. Monthly streamflow changes for most months vary between −13.00% and +32.00%. A shift in monthly maximum streamflow from September to August is projected, while the driest months (December, January and February) show no change in the future. Based on the model results, the White Volta basin will likely experience an increase in streamflow by the mid-21st century. This would call for appropriate investment into cost-effective adaptive water management practices to cater for the likely impact of CC on the future hydrology of the basin.