bluuebunny/crossref_metadata_2025_split huggingface dataset:
Correlation between the mechanism of arteriopathy in IgA nephropathy and blood stasis syndrome: A cohort study
Authors: Wang Ruiqi , Tian Yun 
Published: December 2024

Abstract
To investigate the correlation between blood stasis syndrome and arteriopathy in immunoglobulin A nephropathy (IgAN). Wall thickness/outer vessel diameter, intimal thickness/outer vessel diameter, and medial thickness/outer vessel diameter were measured using ImageJ software. Vascular endothelial-derived growth factor (VEGF), matrix metalloproteinase-9 (MMP-9), proliferating cell nuclear antigen (PCNA), extracellular signal-regulated kinase (ERK) 1/2, and nuclear factor kappa B (NF-κB) were detected by immunohistochemical staining. Twenty-four-hour urine protein quantification, serum creatinine, urea nitrogen, and uric acid were collected. Blood stasis syndrome and vessel scores were calculated based on Katafuchi’s grade. Intimal thickness/outer vessel diameter (0.2725 ± 0.0932 μm), medial thickness/outer vessel diameter (0.2747 ± 0.1139 μm), and wall thickness/outer vessel diameter (0.6136 ± 0.1120 μm) were the largest in IgAN with arteriopathy group. VEGF (0.35 ± 0.90), MMP-9 (0.38 ± 0.12), PCNA (0.43 ± 0.12), ERK1/2 (0.31 ± 0.11), and NF-κB (0.37 ± 0.14) were the highest in IgAN with arteriopathy group. Intimal thickening of IgAN was moderately positively correlated with VEGF, MMP-9, PCNA, ERK1/2, and NF-κB (0.5 < r < 0.8). Medial thickening of IgAN was moderately positively correlated with PCNA and NF-κB (0.5 < r < 0.8). Wall thickening of IgAN was lowly positively correlated with VEGF and MMP-9 (0.3 < r < 0.5). Blood stasis syndrome score was associated with vessel score in IgAN with arteriopathy (P < 0.05). Blood stasis syndrome score can assess the degree of pathological changes.
Exploring the complexity of multilingual spaces: embracing diverse perspectives of linguistic non-understanding
Authors: Goodchild Sam , Weidl Miriam 
Published: December 2024

Abstract
In our article, we investigate the complex dynamics of linguistic understandings and mis- or non-understanding within multilingual contexts. Through the lens of sociolinguistic exploration, we navigate the multifaceted landscapes of language use, applying a multi-perspective approach and the triangulation method to explore the depths of linguistic non-understanding (LNU). Drawing on ethnographic data collection and multi-perspective analysis, we highlight the challenges and opportunities inherent in incorporating LNUs into research practice. Embracing a non-positivist stance, we acknowledge the role of being a ‘non-knower’ in our pursuit of understanding. Our methodology section briefly demonstrates the application of the triangulation method for researching multilingualism, while our empirical findings unveil various instances of LNU across everyday language use. We emphasise the importance of researchers’ reflexivity and the recognition of repertoire users as experts in their linguistic practices. Ultimately, our study offers insights into the analytical advantages of adopting an in-depth and multi-perspective approach to research in multilingual environments.
Pits, houses and rondels: New results on the Lengyel habitation in the Žitava Valley, Southwestern Slovakia
Authors: Wunderlich Maria , Kühl Till , Furholt Kata , Furholt Martin , Cheben Ivan , Bistáková Alena , Winter Ruby , Schönebaum Kai Julian , Löber Ryley , Boensch Victoria-Luise , Müller-Scheeßel Nils 
Published: December 2024

Abstract
As an intensely debated period, the transition from the LBK to post-LBK societies remains in the centre of attention of researchers dealing with the Early Neolithic in Central Europe. The partly drastic change of the settlement systems, regarding both the patterns and organisation, is indeed an interesting subject and raises questions about the social and economic processes and changes that may have accompanied this development. With this contribution, we present new results from extensive survey activities and excavations of Lengyel sites in the Žitava Valley, Southwestern Slovakia. Most notably, the excavation at the previously unknown circular enclosure of Podhájska, built around 4800 calBCE, yielded new data on various aspects of life in Lengyel contexts. Supplemented by geophysical prospections of other rondel and settlement sites, we now begin to understand the transition process from the Early Neolithic to later periods in this regional context. Varying settlement patterns within this small regional context, as well as new forms to express and maintain communality for the dispersed hamlets during the Lengyel period are remarkable signs for societal reorganisation and an adaption to altered needs of the communities involved.
Lei geral de proteção de dados pessoais e o agronegócio: uma análise das implicações aos produtores rurais no município de Palmeira das Missões - Rio Grande do Sul/Brasil
Authors: De Mattos Fagundes Paloma , Stefani Patrícia , Francine Brizola Paola 
Published: December 2024

A intensa utilização de dados pessoais por empresas públicas e privadas, a partir de modernas tecnologias da informação, apresentou novos desafios ao direito à privacidade. Não poderia ser diferente no setor do agronegócio, que impulsionado pelas tecnologias digitais passou a operar com base em dados. A agricultura movida a dados passou a suscitar cuidado no que respeito à coleta e armazenamento de informações pelas partes envolvidas nos processos agropecuários, ocasião em que se passou a refletir sobre o impacto que a Lei Geral de Proteção de Dados ocasionaria no setor do agronegócio. O presente estudo teve como objetivo analisar a percepção do produtor rural em relação à Lei Geral de Proteção de Dados (LGPD) no município de Palmeira das Missões/RS. O estudo é do tipo qualitativo-quantitativo, utilizou como instrumento de coleta de dados um questionário disponibilizado na forma on-line e presencial, o qual foi estruturado com 48 questões e direcionado aos produtores rurais. A partir da pesquisa realizada chegou-se ao resultado que o objeto jurídico tutelado pela LGPD são os dados pessoais e que eles fazem parte do rol de Direitos Fundamentais, adentrando no conceito de privacidade elencado no artigo 5º, inciso X da Constituição Federal. Verificou-se que o nível de implementação da LGPD nas propriedades rurais, atualmente, é baixo devido à falta de conhecimento da lei e de suas implicações jurídicas, cujo efeito promoveu discussões sobre o processo de implementação da referida lei nas propriedades rurais, bem como a titularidade dos dados relacionados a estas atividades. Ficou evidente que a titularidade dos dados gerados a partir das operações agropecuárias pertence aos proprietários rurais, devendo as empresas adotar condutas que minimizem o risco de vazamento de dados a fim de promover o desenvolvimento econômico e tecnológico da cadeia produtiva. Por fim, ficou evidenciada a carência de informação ao produtor rural, por parte das organizações envolvidas no processo e consequentemente a necessidade da criação de políticas de conscientização e informação para efetiva implementação da LGPD para, assim, atingir o ponto de equilíbrio necessário entre a disponibilização de tecnologias digitais e o marco legal de uso de dados.
Újdonságok a mastocytosis diagnózisában és kezelésében
Authors: Várkonyi Judit 
Published: December 2024

A mastocytosis ritka megbetegedés: kb. 10 új beteg megjelenésével lehet számolni évente 100 000 lakosra vonatkozóan. Ez annyit jelent, hogy ma Magyarországon ezres nagyságrendben kellene felismerésre és gondozásra kerüljenek, ami nem történik meg. A klinikánkon megalakult Semmelweis Mastocytosis hálózat elnyerte az európai, 21 ország szakembereit magában foglaló European Competence Network on Mastocytosis (ECNM) kiválósági központjaként történő elismerést. Évente 10–15 új beteget látunk és több mint 150 beteget gondozunk. Az egész országból érkeznek hozzánk. A hálózatban bőrgyógyász, hematológus, patológus működik együtt. Differenciáldiagnosztika tekintetében hálózatunkban HANO (örökletes angioneurotikus oedema) kivizsgálás is történik, triptázszintmérés is bevezetésre került, illetve lehetőség van a myeloid panelben vizsgálni a prognosztikus jelentőségű RUNX1, ASXL1 és SF3B1 mutációkat, valamint tervezzük a herediter alpha triptazaemia TPSAB1 gén mutációjának vizsgálatát. Ez utóbbi a következő WHO-klasszifikációban mint minor kritérium fog szerepelni. Alábbiakban az utóbbi években megjelent legfontosabb publikációk rövid ismertetésén túl az ECNM legutóbbi éves konferencián elhangzott a diagnosztikát és terápiát érintő újdonságokról számolok be.
Outdoor surveillance videos summarization model utilizing CNN-GRU
Authors: Hendi Sajjad H. , Taher Hazeem B. , Hussein Karim Q. 
Published: December 2024

AbstractSurveillance video processing requires high efficiency, given its large datasets, demands significant resources for timely and effective analysis. This study aims to enhance surveillance systems by developing an automated method for extracting key events from outdoor surveillance videos. The proposed model comprises four phases: preprocessing and feature extraction, training and testing, and validation. Before utilizing a convolution neural networks approach to extract features from videos, the videos are pre-processed. Events classification uses gated recurrent units. In validation, motions and objects are extraction then feature extraction. Results show satisfactory performance, achieving 79% accuracy in events classification, highlighting the effectiveness of the methodology in identifying significant outdoor events.
Organizational and applied aspects of follow-up monitoring of patients with prediabetes by a primary care physician. Expert council resolution
Authors: Drapkina O. M. , Lavrenova E. A. , Abdulganieva D. I. , Gomova T. A. , Livzan M. A. , Sanina N. P. , Sharapova Yu. A. , Shepel R. N. , Yafarova A. A. 
Published: December 2024

The steady increase in the prevalence of carbohydrate metabolism disorders worldwide, with the vast majority of type 2 diabetes (T2D), specifies the need to improve disease prevention measures. A special niche in the preventive continuum is occupied by early carbohydrate metabolism disorders, the treatment of which makes a significant contribution to T2D prevention. The absence of a characteristic clinical performance, inadequate apprehensive attitude of healthcare professionals contributes to unnoticed development of carbohydrate metabolism disorders, while progressive disorders lead to micro-, macrovascular complications and the manifestation of T2D. On September 16, 2024, under the chairmanship of Academician of the Russian Academy of Sciences O. M. Drapkina and under the aegis of the Russian Society for the Prevention of Noncommunicable Diseases, the Expert Council was held on Organizational and Applied Aspects of Follow-up Monitoring of Patients with Prediabetes by a General Practitioner. The meeting was attended by the main external experts in internal medicine of regional health protection executive authorities, leading experts of the National Medical Research Center for Therapy and Preventive Medicine and regional branches of the Russian Society for the Prevention of Noncommunicable Diseases, who presented current related problems and proposals for their solution. The Expert Council resolution is presented in this article.
desafios da implementação da Educação 5.0 na Educação Básica
Authors: Felcher Carla Denize Ott , Milhomens David Matos , Silva Michelsch João da 
Published: December 2024

O presente artigo tem como objetivo analisar desafios relacionados à implementação da Educação 5.0 no contexto da Educação Básica. A Educação 5.0 é uma abordagem que integra tecnologias digitais e inteligência artificial para desenvolver competências essenciais para o século XXI. Os dados foram produzidos a partir de um grupo focal com sete professores de escolas públicas, em que foram discutidos os principais desafios da implementação da Educação 5.0. Estes dados foram estudados a partir da Análise de Conteúdo de Bardin e organizados em três categorias e subcategorias. Os resultados mostram que, embora os docentes reconheçam o potencial das tecnologias digitais, eles enfrentam dificuldades para o uso pedagógico desses instrumentos e necessitam de formação continuada. Além disso, a falta de investimentos limita o avanço da Educação 5.0. Para os participantes da pesquisa, os desafios para a implementação da Educação 5.0 relacionam-se com o professor, o estudante e/ou a mantenedora.
The state of postgraduate support for young teachers in the regions of the Russian Federation
Authors: Zolotareva A. V. , Mukhamediarova N. A. , Kharisova I. G. , Khodyrev A. M. 
Published: December 2024

Introduction. The article presents the findings of a study on the state of postgraduate support for young teachers in various regions of the Russian Federation. This research has identified the difficulties, challenges, crises, and barriers that these individuals face when entering the profession.Aim. The present research aims to examine the current state of postgraduate support and retention of young teachers in the Russian Federation, as assessed by the teachers themselves, heads of educational organisations, and instructors from higher education, secondary vocational, and additional vocational education institutions.Methodology and research methods. The methodological foundation of this study is grounded in anthropological, acmeological, systemic, and reflexive-activity approaches. The research is based on an analysis of information regarding the organisation of postgraduate support for young teachers in various types of educational institutions, which was obtained through a survey. A total of 1,103 respondents from 10 regions of the Russian Federation participated in the empirical study.Results. As a fundamental principle in establishing a support system, most respondents emphasise the importance of adhering to priority tasks within the field of education. This reflects their understanding of the significance of the issue at hand, as well as principles related to targeting, individualisation, and the orientation of support aimed at addressing the challenges faced by young teachers. Most respondents advocate for evaluating the effectiveness of initiatives aimed at young teachers based on criteria such as their satisfaction with professional development outcomes and a reduction in the turnover rate of young teachers within the first few years of their careers. Furthermore, both teachers and administrators are generally well-informed about the resources available to support young educators and largely agree on their potential effectiveness. They also recognise that the support of young teachers is a manageable process, involving the active participation of many teachers and administrators. Additionally, young teachers themselves play an active role in organising this support.Scientific novelty. The scientific novelty of this study lies in the generalisation of existing trends and issues, the identification of priority tasks, principles, directions, and methods for establishing a system of postgraduate support and retention for young teachers in the profession. Practical significance. The results obtained can be utilised to design a support system for young teachers, including those in postgraduate programmes, while considering the unique characteristics of various types of educational organisations.
Comparative evaluation of broth microdilution, E-strip and Vitek-2 for colistin susceptibility among carbapenem resistant Acinetobacter Spp and Klebsiella Spp
Authors: Basavaraju Monisha , Rao M Raghavendra , Shankaregowda Ranjitha , Mahale Rashmi , Shivappa Sowmya G , Chitharagi Vidyavathi B 
Published: December 2024

Gram-negative bacterial infections that are resistant to carbapenems are a serious clinical problem. The only effective drugs against them are still tigecycline and colistin. In fact, polymyxin E, also known as colistin, has been regarded as a "last resort" antibiotic. But in recent years, colistin resistance has increased globally, significantly reducing treatment options and highlighting the significance of accurate colistin testing methods to support appropriate therapeutic decision-making. There is no requirement to cite reference in the abstract. So it is suggested to rephrase the sentence. The primary goal of the study is to compare the effectiveness of E-test and Vitek 2 for colistin sensitivity testing to the conventional microbroth dilution method using 120 clinical isolates of and that are resistant to carbapenem over the course of a year, isolated from January to December 2019. In comparison to Vitek-2, the results indicated that brothmicro dilution and E-test produced the narrowest range of colistin MICs. After comparing the E-test's errors and overall agreement with BMD, 100% of the Essential Agreement, 94.27% of the Categorical Agreement, and 5.72% of the Very Major Errors with no Major Errors were found. Comparing Vitek-2 with BMD, similar results were found: 1.66% MEs, 98.32% CAs, 80.99% EAs, and no VMEs. As a result, it was determined that, in contrast to Vitek-2, MBD and E-test had distinct MICs, making them appropriate for determining colistin MIC. It will take more research on automated systems to standardize colistin susceptibility testing procedures, particularly for and .
Comparative evaluation of phenotypic methods to detect methicillin resistance with mecA gene detection by PCR in Staphylococcus aureus
Authors: Sony S  , Haneefa Sahira , Suresh Manjusree 
Published: December 2024

It is crucial to employ precise, reliable, and rapid detection methods to avoid the indiscriminate use of antimicrobial drugs and make informed decisions regarding appropriate treatment and the execution of efficient measures to prevent infections.: A group of 112 isolates from different clinical specimens, initially identified as using the cefoxitin disc diffusion test, underwent additional phenotypic tests such as the Oxacillin E strip and MRSA CHROM agar. These methods were then evaluated and compared with gene detection via PCR, which is regarded as the gold standard. Of the 112 isolates identified by the cefoxitin disc diffusion test, 101 (90.2%) tested positive for the gene. The Oxacillin E strip had a sensitivity of 98% and a specificity of 91%, while MRSA CHROM agar showed a sensitivity of 96.03% and a specificity of 82%. Among the 101 mec A-positive isolates, 44.5% met the CDC definition criteria for . : Our study concludes that phenotypic methods, including the cefoxitin disc diffusion test, are not completely reliable in detecting methicillin resistance in According to our results, combining the cefoxitin disc diffusion test with the oxacillin E strip is an effective approach for detecting in resource-constrained settings. Given the advantages of PCR, it is recommended to perform PCR for gene detection on a regular basis to identify strains in important clinical specimens.
Impact of multi-modal learning workshop on awareness and knowledge of health care providers about waste management in India
Authors: Murugesan Malathi , Joseph Lallu , Agarwal Vijay , Jayarajan Jayalakshmi , Ramasamy Jagadish , Poojary Aruna , Madhu Deepthi 
Published: December 2024

Hospital waste management is crucial in preventing needle stick injuries and exposure to hazards. Adequate knowledge, appropriate safety measure, and methods of handling the wastes are more important in waste management. : The objective of this project is to study the impact of multi-modal training workshops in improving the knowledge and awareness on biomedical waste management among healthcare workers.An eight-hour onsite training workshop was conducted in Ahmedabad, Kolkata, Indore, and Hyderabad from July to September 2023. A validated pre and post-test questionnaire was used to assess the impact of the workshop. At the end of each workshop, responses were analyzed to study the effectiveness of the workshop and to do a gap analysis on the areas that require strategic learning. Analysis was conducted on data aggregated using the Chi-square test.In the above analysis, the pre-test scoring of these participants was 66%. After the workshop, the post-test scoring was 83% with a significant improvement (p &#60; 0.0001). The pre-test and post-test scores in individual regions were 63% and 78% at Ahmedabad, 71% and 86% at Kolkata, 60% and 86% at Indore, and 68% and 83% at Hyderabad respectively.In healthcare facilities, training plays a key role in preventing health hazards for both employees and patients. Training must involve different types of learning methods tailored to the needs and capability of understanding of the participants. The effectiveness of training must be measured using appropriate tools to study the impact of the learning methods.
Enhancing neonatal sepsis detection: A comparative analysis of interleukin-6 and the BacT/ALERT blood culture system
Authors: Kumar Vivek , Saini Narendra , Kumar Gunjana 
Published: December 2024

One of the main causes of newborn mortality is neonatal sepsis, which has to be diagnosed quickly and precisely. Although the Bact/ALERT method for blood culture is commonly used, it is often slow, for early identification of sepsis, interleukin-6 (IL-6) provides a quicker substitute. : This study evaluates how well the BacT/ALERT system and IL-6 diagnose newborn sepsis, aiming to determine the most reliable and timely method for improving neonatal outcomes. A clinician at the National Institute of Medical Sciences & Research who admitted neonates to the neonatal intensive care unit (NICU) suspected 120 newborns of having sepsis. The inclusion criteria were satisfied by newborns between the ages of 0 and 28 days who showed clinical signs of sepsis. Exclusion criteria included infants with congenital anomalies or those who had received antibiotics before sampling. In this study of 120 neonates, IL-6 levels were elevated in 45% of the cases, with a sensitivity of 100%, specificity 86.84%, PPV 81.48% and NPV 100% for. 36.67% of samples had bacterial growth identified by the BacT/ALERT system. In just three hours, IL-6 produced results, which was far quicker than the BacT/ALERT method. IL-6 is a rapid, sensitive marker for neonatal sepsis, offering faster diagnosis than BacT/ALERT. Combining both methods may improve early detection and treatment outcomes. IL-6 offers rapid, high-sensitivity sepsis detection compared to BacT/ALERT, which, despite being slower, is crucial for pathogen identification. Combining both methods could enhance early diagnosis and treatment.