bluuebunny/crossref_metadata_2025_split huggingface dataset:
Experimental Study to Investigate the Effect of Backfilling Materials
on Thermal Performance of Ground Air Heat Exchanger System
Authors: Agrawal Kamal Kumar , Misra Rohit , Agrawal Ghanshyam Das 
Published: July 2019

Abstract
In ground air heat exchanger (GAHE) system, the heat transfer between air and underground soil largely depends on soil thermal properties and therefore, any improvement in soil thermal properties will shorten the pipe length required and the land area needed for its installation. The objective of the present study is to investigate the effect of different backfilling materials (low cost and locally available) on the thermal performance of GAHE system using a small-scale laboratory experimental setup. Seven different backfilling materials have been considered for the study and it was observed that after 6 h of continuous operation, the drop in air temperature was 6.2 °C at outlet section of pipe (2.4 m away from inlet) for the native soil. However, for sand–bentonite with graphite as a backfilling material (BFM), the drop in air temperature of 6.2 °C was obtained at a pipe length of 1.15 m only. Therefore, the use of sand–bentonite with graphite as a BFM reduces the pipe length of GAHE system by more than 50%. The study establishes the fact that the length of pipe and land area requirement for GAHE system can be substantially reduced by using thermally enhanced backfilling materials at the close vicinity of GAHE pipes.
Fumaratehydratase-deficient renal cell carcinoma: a clinicopathological and molecular study of 13 cases
Authors: Pan Xiuyi , Zhang Mengni , Yao Jin , Zeng Hao , Nie Ling , Gong Jing , Chen Xueqin , Xu Miao , Zhou Qiao , Chen Ni 
Published: July 2019

AimsHereditary leiomyomatosis and renal cell carcinoma (HLRCC) is a newly recognised entity in the WHO 2016 classification defined as the germline mutation ofFHgene. Fumaratehydratase-deficient renal cell carcinoma (FH-deficient RCC) is recommended for tumours with FH deficiency but lacking of genetic evidences ofFHgermline mutation. In this study, we described the clinicopathological and molecular changes of 13 FH-deficient RCCs.Methods and resultsHistology features, clinicopathological data, radiology performance and outcomes were collected for each patient. Next-generation sequencing and DNA sequencing ofFHgene were performed to examine FH mutations. The patient group included five females and eight males. Different morphological patterns of papillary, nested, adenoid, foam adenoid, cribriform, tubular, tubulocystic, cystic and loose oedema stroma were observed. Except typical big nuclei with or without eosinophilic nucleoli and perinucleolar halos, raisin-like, hobnail-like and even low-grade nuclei were also observed in these tumours. Eleven cases with high-grade nuclei showed disease progression or death, but no disease progression was detected in two cases with low-grade nuclei and eosinophilic cytoplasm. FH expression was absent in tumour cells except for case 11. Next-generation sequencing and DNA sequencing verified seven FH germline mutations and four somatic mutations out of 13 cases.ConclusionsFH-deficient RCC is a rare renal tumour and has a wide morphological spectrum. Most of the tumours had high-grade nuclei and were aggressive. However, we observed a morphological subtype of FH-deficient RCC with low-grade nuclei and eosinophilic cytoplasm, which might mainly occur in young women and show a relatively good prognosis.
Urine 5MedC, a Marker of DNA Methylation, in the Progression of Chronic Kidney Disease
Authors: Onishi Akifumi , Sugiyama Hitoshi , Kitagawa Masashi , Yamanari Toshio , Tanaka Keiko , Ogawa-Akiyama Ayu , Kano Yuzuki , Mise Koki , Tanabe Katsuyuki , Morinaga Hiroshi , Kinomura Masaru , Uchida Haruhito A. , Wada Jun 
Published: July 2019

Background. Alterations in DNA methylation may be involved in disease progression in patients with chronic kidney disease (CKD). Recent studies have suggested that 5-methyl-2′-deoxycytidine (5MedC) may be a marker of hypermethylation of DNA. Currently, there is no information available regarding the urine levels of 5MedC and its association with the progression of CKD. Method. We examined the urine levels of 5MedC in spot urine samples from 308 patients with CKD (median age: 56 years, male: 53.2%, and glomerulonephritis: 51.0%) using a competitive enzyme-linked immunosorbent assay and investigated the relationships among urine 5MedC, urine albumin, urine α1-microglobulin (α1MG), and the laboratory parameters associated with CKD. The patients were followed for three years to evaluate renal endpoints in a prospective manner. Results. The urine 5MedC level was significantly increased in the later stages of CKD compared to the early to middle stages of CKD. In multiple logistic regression models, urine 5MedC was significantly associated with the prediction of later CKD stages. Urine 5MedC (median value, 65.9 μmol/gCr) was significantly able to predict a 30% decline in the estimated GFR or a development of end-stage renal disease when combined with macroalbuminuria or an increased level of urine α1MG (median value, 5.7 mg/gCr). Conclusion. The present data demonstrate that the urine 5MedC level is associated with a reduced renal function and can serve as a novel and potent biomarker for predicting the renal outcome in CKD patients. Further studies will be necessary to elucidate the role of urine DNA methylation in the progression of CKD.
Trastorno de alimentación: identificación y primeras intervenciones para los profesionales de salud.
Authors: CORDELLA MASINI MARIA PATRICIA 
Published: July 2019

los trastornos de la alimentación e ingesta (TAI) son un complejo conjunto interdimensional de enfermedades mentales que afectan el rendimiento corporal, mental y social. El núcleo de la enfermedad es el miedo a ganar peso. Las estrategias de control de ingesta varían entre: restricción, selección y purga alimentaria. Afectan diferentes sexos, razas, etnias y edades. Con mayor frecuencia en adolescentes y mujeres jóvenes (9: 1). Presentan alta mortalidad, comorbilidad mental y conflictos familiares asociados.Método: integrar información disponible y útil según criterio de experto, orientada al manejo clínico de los TAI. Resultado: debido a que los profesionales de salud de diferentes áreas podrían ser el único contacto que el/la paciente busca para aliviar alguna dolencia aparentemente no relacionada con TAI, es necesario lograr identificar y diagnosticar los estadios patológicos e indicar las primeras conductas, así como hacer una referencia exitosa. El retraso en el diagnóstico causa alteraciones severas y crónicas en la fisiología, el comportamiento, la cognición y el funcionamiento psicosocial. Los objetivos de este estudio son: a. Presentar, en forma integrada, la información disponible de modo de facilitar a los profesionales de la salud la detección precoz de los TAI; b. Ofrecer un conjunto de acciones útiles que faciliten el diagnóstico TAI; c. Organizar la comprensión del riesgo TAI en un diagrama que facilite la construcción de la derivación utilizando las dimensiones: cuerpo, mente, relaciones; d. Mostrar las alternativas psicoterapéuticas en uso e. Proveer información para realizar las primeras intervenciones. Conclusión: reconocer tempranamente el cuadro TAI puede detener el curso patológico y los potenciales daños.
Síndrome de Kounis como manifestación de anafilaxia
Authors: Orozco Chinome Javier Esteban , Picón Jaimes Yelson Alejandro , Ortega Uribe Leec Fabían-David 
Published: July 2019

Introducción: el síndrome de Kounis corresponde a la isquemia miocárdica aguda relacionada con la liberación de mediadores inflamatorios que llevan a vasoespasmo coronario y/o complicación de una placa ateromatosa durante una reacción alérgica. La incidencia de eventos coronarios en procesos alérgicos en Estados Unidos es de 8 casos por 100000 habitantes por año. Métodos: describimos el caso de una mujer que desarrolla síndrome de Kounis, posterior a múltiples picaduras de abeja, recibiendo manejo en una unidad de cuidado intensivo de una institución de salud de Colombia. La paciente presentó un síndrome coronario agudo tipo infarto agudo de miocardio con elevación del segmento ST, con arteriografía coronaria en la cual se evidenció ausencia de lesiones vasculares o vasoespasmo, con presencia de un trombo flotante en la arteria descendente anterior, sin evidencia de enfermedad ateroesclerótica. Resultados: el síndrome de Kounis es frecuente en los pacientes con anafilaxia, sin embargo, se informa poco en la literatura, debido a la falta de sospecha diagnostica y al poco reconocimiento clínico. Los síntomas de este síndrome pueden ser típicos como el dolor torácico opresivo de gran intensidad irradiado a miembro superior izquierdo o a cuello, o atípicos como disnea, nauseas o palpitaciones, los cuales pueden confundirse con las manifestaciones del proceso anafiláctico. Conclusiones: en la actualidad no existen guías para el tratamiento del síndrome y depende de la forma de presentación, comorbilidades y disponibilidad de un grupo médico interdisciplinar, que incluya monitoria y vigilancia en una unidad de cuidado intensivo.
Body Composition and Aspirin Dose for Colorectal Adenoma Prevention in a Randomized Clinical Trial
Authors: Passarelli Michael N. , Barry Elizabeth L. , Rees Judy R. , Mott Leila A. , Ahnen Dennis J. , Baron John A. 
Published: July 2019

Abstract

Background:
Visceral adiposity is a risk factor for colorectal adenomas, and aspirin is an established chemopreventive agent. Evidence from clinical trials suggests the effectiveness of aspirin at preventing cardiovascular disease and cancer may require higher doses for higher body weight.

Methods:
Body mass index, body surface area, fat-free mass, and fat mass were calculated from baseline height and weight in 1,121 participants of the Aspirin/Folate Polyp Prevention Study, a double-blind, placebo-controlled, 3 × 2 factorial randomized clinical trial of low-dose (81 mg/day) or high-dose (325 mg/day) aspirin and/or 1 mg/day folic acid to prevent metachronous colorectal adenomas. Participants were treated during a surveillance colonoscopy interval of approximately 3 years. Risk ratios (RR) with 95% confidence intervals (CI) for any colorectal neoplasia and high-risk adenoma (HRA, advanced or ≥3 adenomas) were estimated from log-linear regression.

Results:
We did not find evidence to suggest aspirin dose-response differed by body composition measurements, including weight alone. Among those weighing ≥ 80 kg, treatment effects for low-dose aspirin (RR for colorectal neoplasia, 0.75; 95% CI, 0.60–0.94; RR for HRA, 0.52; 95% CI, 0.31–0.86) and high-dose aspirin (RR for colorectal neoplasia, 0.88; 95% CI, 0.72–1.08; RR for HRA, 0.68; 95% CI, 0.43–1.09) were not meaningfully different than for those weighing 70–79 kg or &lt;70 kg.

Conclusions:
Measurements of body composition calculated from height and weight did not modify aspirin treatment effects for colorectal adenoma prevention.

Impact:
Aspirin dosing strategies accounting for body weight suggested in previous trials of colorectal cancer may not apply to adenomas.
Oncogenic KRAS Induces NIX-Mediated Mitophagy to Promote Pancreatic Cancer
Authors: Humpton Timothy J. , Alagesan Brinda , DeNicola Gina M. , Lu Dan , Yordanov Georgi N. , Leonhardt Carl S. , Yao Melissa A. , Alagesan Priya , Zaatari Maya N. , Park Youngkyu , Skepper Jeremy N. , Macleod Kay F. , Perez-Mancera Pedro A. , Murphy Michael P. , Evan Gerard I. , Vousden Karen H. , Tuveson David A. 
Published: July 2019

Abstract

Activating KRAS mutations are found in nearly all cases of pancreatic ductal adenocarcinoma (PDAC), yet effective clinical targeting of oncogenic KRAS remains elusive. Understanding of KRAS-dependent PDAC-promoting pathways could lead to the identification of vulnerabilities and the development of new treatments. We show that oncogenic KRAS induces BNIP3L/NIX expression and a selective mitophagy program that restricts glucose flux to the mitochondria and enhances redox capacity. Loss of Nix restores functional mitochondria to cells, increasing demands for NADPH reducing power and decreasing proliferation in glucose-limited conditions. Nix deletion markedly delays progression of pancreatic cancer and improves survival in a murine (KPC) model of PDAC. Although conditional Nix ablation in vivo initially results in the accumulation of mitochondria, mitochondrial content eventually normalizes via increased mitochondrial clearance programs, and pancreatic intraepithelial neoplasia (PanIN) lesions progress to PDAC. We identify the KRAS–NIX mitophagy program as a novel driver of glycolysis, redox robustness, and disease progression in PDAC.

Significance:
NIX-mediated mitophagy is a new oncogenic KRAS effector pathway that suppresses functional mitochondrial content to stimulate cell proliferation and augment redox homeostasis. This pathway promotes the progression of PanIN to PDAC and represents a new dependency in pancreatic cancer.
This article is highlighted in the In This Issue feature, p. 1143
Mitochondrial Homeostasis in AML and Gasping for Response in Resistance to BCL2 Blockade
Authors: Savona Michael R. , Rathmell Jeffrey C. 
Published: July 2019

Abstract

Summary:
Understanding resistance to BCL2 inhibition is a critical scientific and clinical challenge. In this issue of Cancer Discovery, two laboratories use unbiased approaches of large loss-of-function CRISPR/Cas 9 screens to discover targetable liabilities in cell signaling and metabolism to acute myeloid leukemia resistant to BCL2 inhibition.
See related article by Chen et al., p. 890.
See related article by Nechiporuk et al., p. 910.
Vergilius Astronomiae Ignarus?
Authors: Bakker Frederik A. 
Published: July 2019

AbstractBoth in antiquity and today Virgil is sometimes accused of ignorance in astronomy. This paper argues that, on the contrary, Virgil’s treatment of astronomical topics in Georgics 1.231-258 shows that he was quite familiar with the subject, and was able (when he wished to) to combine information from different sources (Aratus, Eratosthenes and other, unidentified ones) into a sensible and harmonious whole. On the other hand, the omission of essential steps between the various parts of his account, and the deliberate confusion of science and myth show us that his ultimate aim was not to inform the ignorant but to amuse and surprise readers who were just as familiar with astronomy as Virgil himself.
Greek and the Indo-European Verb
Authors: Kölligan Daniel 
Published: July 2019

AbstractThis article reviews Andreas Willi’s study of the history and prehistory of the Greek and Proto-Indo-European (PIE) verbal system which tries to put the data of one of the ‘classical’ languages of PIE reconstruction back onto the centre stage after much attention has been given to Anatolian (Hittite, etc.) and Tocharian in recent decades. It argues that in the earliest reconstructable phase PIE had ergative alignment and that the switch to nominative-accusative alignment triggered a series of changes leading to the distribution of stem formations found in Greek and other ancient PIE languages (root aorists, reduplicated aorists and presents, thematic aorists and presents, s-aorists and s-futures, etc.). The review tries to show that the study presents a series of thought-provoking and well-argued hypotheses, while with its focus on prehistory its philological analyses tend to rely on a few chosen examples.
Self-Knowledge in the Eye-Soul Analogy of the Alcibiades
Authors: Ferguson Daniel 
Published: July 2019

AbstractThe kind of self-knowledge at issue in the eye-soul analogy of the Alcibiades (132d5-133c7) is knowledge of one’s epistemic state, i.e. what one knows and does not know, rather than knowledge of what one is. My evidence for this is the connection between knowledge of one’s epistemic state and self-improvement, the equivalence of self-knowledge to moderation, and the fact that ‘looking’ into the soul of another is a metaphor for elenctic discussion. The final lines of the analogy (133c1-7) clarify that the part of the soul one ‘looks’ into and the part one learns about when learning about one’s epistemic state is divine.
The Carabao and the Encounter of the Law in Nineteenth-Century Philippines
Authors: Ludovice Nicolo Paolo P. 
Published: July 2019

AbstractThe place of the non-human animal in the legal world has been questioned. Animals’ legal status as property has been probed on how to best protect their welfare. While this is significant for animals who are not on the farm, it might not be effective when considering animals raised for food. The case of the carabao, or the water buffalo, in the Philippines is seen as a hybrid. This article traces the development of the carabao in Philippine history during the nineteenth century. Through historical, archival, and legal research on animals, the carabao is situated as private property. Colonial instruments of control were introduced to protect the carabao from criminals. In its proper historical context, the classification of carabaos as property indeed highlighted the animal’s status as legally owned, which did not necessarily demean the animal’s relationship with the human peasant nor the carabao’s quality as an animal.
You Speak What They Wear
Authors: Li Larry Hong-lin 
Published: July 2019

Abstract
We manipulated persona features characterising US and Taike subcultures, and examined its impact on preference toward Chinese-English alternated uses among Taiwanese youngsters. We conducted (i) a literature survey to identify the features iconic of US and Taike subcultures, (ii) a norming task to verify the subculture icons obtained, (iii) a multi-choice task to survey preference for six relevant non-/mixed forms of language, (iv) a forced-choice task to inspect “relative” code choices between Chinese versus its code-mix with English elements under the cues of the probe features. We found that visual cues and the stereotypical generalisations thereof play a role in language negotiation in first meeting contexts; cultural personae manifest themselves in the language alternation; with code mixing as an accommodative move, language users self-categorise themselves with the interlocutor that is stereotyped as having a linguistic preference associated to their persona character; linguistic convergence to stereotypes is driven by unconscious need.
Articulation of Movement Demands and the Politics of Solidarity against Extractive Capital in Bangladesh
Authors: Faruque M. Omar 
Published: July 2019

Abstract
How do disparate grievances join to form an agenda for collective action? This article analyses the articulation of movement demands and solidarity building during the formative phase of a popular mobilisation against a multinational mining company in Bangladesh. Drawing on a conceptual framework derived from Laclauian discourse theory, I explain how local community resistance inspired various social groups to support an anti-corporate social movement, ultimately defeating the mining company. I explain how the construction of an empty signifier had the capacity to connect disparate groups to oppose a common enemy. This analysis is based on a set of interviews with activists and a close reading of organisational documents. The examination of how movement demands are articulated emphasises the role of movement intellectuals and enriches the theorising of social movements in the Global South.
The Historical Development of Indonesian Social Security
Authors: Murphy John 
Published: July 2019

Abstract
Indonesia’s National Social Security System (SJSN) aspires to universal coverage of insurance for health, retirement, and occupational benefits, such as employment injury. This article surveys the successive layers of policy development since the 1960s, in pensions and health benefits for some, and in social assistance programmes for the poor in the Reformasi era. Clarifying the nature of prior developments helps to understand the challenges facing the SJSN. These initiatives are assessed in terms of the literature on welfare regimes, applied as an interpretative tool, rather than in the expectation Indonesia fits the often-rigid categories of welfare typologies.
From the Demise of Social Democracy to the ‘End of Capitalism’
Authors: Roos Jerome 
Published: July 2019

Abstract
Over the past decade, Wolfgang Streeck has emerged as one of the most prominent voices in the debate on the crisis of democratic capitalism. This article provides a critical appraisal of Streeck’s recent writings in light of his wider intellectual trajectory, tracing the evolutions and continuities in his work over time; highlighting its important contributions to our understanding of the present crisis; and presenting a fourfold critique of his latest book on the end of capitalism. The main argument is that Streeck’s work, while very valuable for its elucidation of the dynamics behind the demise of social democracy, ultimately remains plagued by a corporatist residue that keeps him from drawing his increasingly radical critique of capitalism to its logical conclusions. As a result, Streeck’s embrace of an exceedingly catastrophist worldview, devoid of any emancipatory potential, has tempted him to veer dangerously close to the welfare chauvinism of the nationalist right.
God and His Works from an Entrepreneurship Perspective
Authors: van der Kooi Cornelis , Rietveld Cornelius A. 
Published: July 2019

Abstract
This article explores to what extent God and his works can be understood in terms of entrepreneurship. We give several theological reasons for using this lens, and we survey briefly the use of the word ‘oikonomia’ in the New Testament, the early church, and Reformed theology. Thereafter, we investigate how the entrepreneurship metaphor fits the narrative of the Bible. We argue that by looking at how features of entrepreneurship can be found in the way in which the triune God acts, we obtain a more comprehensive view on our history as a risky drama between God and humanity. The metaphor also highlights the important role played by humans in letting creation flourish.
Epistemic modality, particles and the potential optative in Classical Greek
Authors: la Roi Ezra 
Published: July 2019

AbstractThis paper challenges the commonly held view that the Classical Greek potential optative has a subjective epistemic semantics, the result of a conceptual confusion of subjectivity and epistemic modality inherited from our standard grammars. I propose that this view becomes less convincing when the optative’s unique interaction with the subjective particles ἦ and ἄρα is incorporated into the analysis. Rather, the potential optative has a non-subjective epistemic semantics presenting an epistemic judgment as interpersonally accessible to the conversational participants. Frequencies of combination with ἦ and ἄρα, linguistic tests for subjectivity on the potential optative, and contrastive contextual analyses corroborate this view.