bluuebunny/crossref_metadata_2025_split huggingface dataset:
Manufacturing of Submicrofluidic Channels Based on Near-field Electrospinning with PEO
Authors: Zhang Jiarong , Wang Han , Wang Zhifeng , Yao Honghui , Xu Guojie , Yan Shengyong , Zeng Jun , Zhu Xiangyou , Deng Jiannan , Zhuo Shaomu , Zeng Jinghua 
Published: September 2019

Background:
Microfluidic channels have been widely applied in biomedicine and microelectronics.
However, the manufacturing methods of microfluidic channel devices, such as photolithography,
three-dimensional printing and Melt-electrospinning direct writing (MEDW), have the problem
of high cost and complex process, which still can't reach a sub-micron scale stably.

Method:
To improve the resolution of microfluidic channels, we developed a simple and flexible
method to fabricate polydimethylsiloxane (PDMS) submicrofluidic channels. It depends on the following
steps: (1) Direct Writing Polyethylene oxide (PEO) nanofiber by Near-field Electrospinning
(NFES). (2) Packaging the nanofiber with PDMS. (3) Obtaining the PDMS submicrofluidic channel
by inverted mode of PEO nanofiber.

Results:
According to the result of the experiment, nanofiber can be stably prepared under the following
conditions, the electrode-to-collector distance of 3.0 mm, the voltage of 1.7 KV, the collector
moving speed of 80mm/s and the mixed solutions of ethanol and deionized water (1:1). Finally, the
PDMS submicrofluidic channel was manufactured by NFES and PDMS molding technique, and the
diameter of the channel was 0.84±0.08 μm.

Conclusion:
The result verified the rationality of that method. In addition, the method can be easily
integrated with high resolution channels for various usages, such as microelectronics, micro electro
mechanical systems, and biomedical.
Transcriptomic Analysis of the Aquaporin Gene Family and Associated Interactors in Rectal Cancer
Authors: Magouliotis Dimitrios E. , Tasiopoulou Vasiliki S. , Baloyiannis Ioannis , Mamaloudis Ioannis , Tzovaras George 
Published: September 2019

Background:
Rectal Cancer (RC) is a common type of cancer with poor prognosis. The
identification of biomarkers regarding RC diagnosis, monitoring, and prognosis is crucial.

Objectives:
The purpose of the present study was to evaluate the differential expression of the Aquaporin
(AQP) gene family network in RC, and the effect of Radiotherapy (RT) on their expression
profile, to indicate novel biomarkers and prognostic factors.

Methods:
We used data mining techniques to construct the network of the AQP-associated genes to
determine the Differentially Expressed Genes (DEGs) in RC and in irradiated as compared to nonirradiated
RC patients. Furthermore, survival data of The Cancer Genome Atlas (TCGA) were analysed
to assess the prognostic role of the DEGs, along with the functional enrichment of gene ontologies
and miRNAs related to the DEGs in RC.

Results:
Microarray data of one PubMed GEO dataset was extracted, incorporating 22 RC and 20
normal rectal tissue samples. Eight DEGs were reported. Four DEGs were up-regulated and four
downregulated in RC. Correlations were identified among the DEGs. Deming regression analysis
was performed in order to demonstrate the equations describing these correlations. One gene (Aquaporin
3) was downregulated in irradiated RC samples compared with non-irradiated samples. The
most significantly affected biological pathways and miRNAs were identified by functional enrichment
analysis.

Conclusion:
The present study demonstrates an eight-gene molecular panel that could facilitate as
biomarkers regarding RC patients, which are potential targets of five miRNA families. Finally, our
results highlight the effect of radiotherapy on AQPs and the associated pathways in RC.
Recent Patents on Radiotherapy Bed
Authors: Zhang Yongde , Dai Xuesong , Jiang Jingang , Yang Zhikang , Qin Peiwang 
Published: September 2019

Background:
In order to increase the accuracy of radiotherapy and to improve the patient's
comfort, diverse structures of radiotherapy bed have been designed and improved constantly.

Objective:
To provide an overview of recent patents about radiotherapy bed and to introduce their characteristics
and development.

Methods:
In this study, various representative patents related to the radiotherapy bed were reviewed.
Additionally, the structural characteristics and applications of the typical radiotherapy bed were introduced.

Results:
The characteristics of different radiotherapy beds were analyzed and concluded. Moreover, the
main problems concerning their development were analyzed, and the current and future developments
of patents on radiotherapy bed were also discussed.

Conclusion:
Radiotherapy bed is an important part of radiotherapy system, which also determines the
therapeutic outcomes of radiotherapy. Further improvements are required in the aspects of accuracy,
comfort, flexibility and result stability of the radiotherapy bed. More invention should be laid on more
patents on radiotherapy beds.
MEDICINAL PLANTS OF SELECTED WETLANDS IN ARIYANNUR, THRISSUR DISTRICT, KERALA–A PRELIMINARY STUDY
Authors: ATHIRA K. R. 
Published: September 2019

Objective: Wetlands are a vital ecosystem which provides livelihoods for millions of people who live within around them. The main aim of this study is to identify the wetland medicinal plants, medicinal values of wetland medicinal plants, to evaluate the current status of the medicinal plant diversity in wetlands of Ariyannoor area, importance of wetlands, to build awareness.
Methods: Frequent field visits were carried out from September 2018 to January 2019 to collect different Wetland medicinal plants in Ariyannur area, Kandanassery Panchayath, Thrissur district. Plants were collected carefully with hand and identified by using the standard literature such as Flora of the Presidency of Madras by J. S. Gamble, 1915-1936. The collected plants were authenticated by a plant Taxonomist Dr. Udayan. P. S. A total of 10 plant species was collected and identified during the investigation with potential medicinal value.
Results: These plants are used for curing more than 20 diseases, including Blood dysentery, cough and cold, skin diseases, anemia etc. Herbs have been called part of “nature’s pharmacy”. Although their action can in some ways be similar to modern drugs, herbal remedies are generally gentler and safer. Many of the drugs used in conventional medicine are derived from herbs [1].
Conclusion: Slight alteration of the wetland may result in the disappearance or the extinction of these plants2. This will ultimately result in large scale economic loss in terms of the medicinal product. Apart from the loss of plants, this will also result in the loss of local knowledge on the medicinal properties of these plants which very often can't be retrieved. An attempt has been made to document some of the little known medicinal properties of wetland plants used by local community.
ASSESSMENT OF MEDICATION ADHERENCE AMONG ELDERLY PATIENTS IN MYSURU CITY
Authors: KUMAR JAIDEV , MAHENDRAPPA  , KUMAR PRAMOD 
Published: September 2019

Objective: To assess medication adherence among patients with chronic diseases.
Methods: This was a prospective observational study carried out over period of one year in mysuru city. The subjects who meet study criteria were enrolled in this research study. The enrolled subjects were administered with simplified medication adherence questionnaire. The criteria to establish adherent and non-adherent were calculated as per simplified medication adherence questionnaire directions.
Results: The gender distribution of this research study was reflected with male accountable for 45.63 % followed by female 54.36%. Asper simplified medication adherence questionnaire88% were adherent and remaining 12% were non-adherent in this research study.
Conclusion: Patients with good adherence in this research study showed that they have good literacy status as well as better awareness about the existing medical condition and more consciousness may be there among these patients, what will be going to happen if their medical condition is left untreated.46.29 % males and 59.58 % females were adherent in this research study followed by 59.24% were adherent in the age range of 60-70 y as they were more conscious and less forgetfulness about medications as per the directions given by patient consultant which was oral feedback taken by research investigators during medication review in subjects home.
DESIGN, OPTIMIZATION AND EVALUATION OF IBUPROFEN FAST DISSOLVING TABLETS EMPLOYING STARCH PHTHALATE-A NOVEL SUPERDISINTEGRANT
Authors: KUMAR R. SANTOSH , ANNU KUMARI , LATHA B. KUSUMA , MALLIKA T. 
Published: September 2019

Objective: The objective of the present research was to prepare starch phthalate (a novel super disintegrant) and to optimize and formulate ibuprofen fast dissolving tablets employing 23factorial design using starch phthalate as super disintegrant.
Methods: Drug excipient compatibility studies like Fourier-transform infrared spectroscopy (FTIR) and thin-layer chromatography (TLC) studies were carried out to check the drug interaction between ibuprofen and starch phthalate. Direct compression method was used for tablet preparation. Prepared tablets were then evaluated for hardness, friability, drug content, disintegration time, water absorption and wetting time, in vitro dissolution studies. Response surface plots and contour plots were also plotted to know the main effects and interaction effects of independent variables (starch phthalate (A), croscarmellose sodium (B) and crospovidone (C)) on dependent variables (disintegration time and drug dissolution efficiency in 1 minute) and stability studies were also done.
Results: Tablets of all formulations were of good quality concerning drug content (100±5%), hardness (3-6 kg/cm2), and friability (less than 0.16%). In all formulations, formulation F5 found to be optimized formulation with least disintegration time 20±0.28 seconds, less wetting time 09±0.12 seconds and enhanced dissolution rate in one minute, i.e., 91.95±0.22 as compared to other formulation.
Conclusion: From the research, it was concluded that on combination with crospovidone, starch phthalate enhanced the dissolution efficiency of the drug. Hence, starch phthalate can be used as a novel disintegrant in the manufacturing of fast dissolving tablets.
DRUG INDUCED DERMATOLOGICAL REACTION OF THE 100 MOST COMMONLY PRESCRIBED MEDICATIONS IN UK HOSPITALS
Authors: AL-ABADIE MOHAMMED , OUMEISH FARIS , AL-RUBAYE MOHAMMED , AL-ABADIE DINA , BALL PATRICK ANTHONY , MORRISSEY HANA 
Published: September 2019

Objective: It is commonly reported that medicines have side effects related to dermatological practice. However, it is extremely difficult to establish how commonly, or rarely skin-related medication side effects occur. Common dermatological side effects include rash, pruritus, and photosensitivity.
Objective: To demonstrate the dermatological side-effects of the most commonly prescribed medications in the United Kingdom.
Methods: This paper discusses dermatological side-effects of the commonly prescribed medications, including uncommon or rare manifestations such as angioedema and Stevens - Johnson syndrome (SJS). The list used for the most frequently prescribed drugs in the United Kingdom was created by nurses. This list was compared to the British National Formulary to demonstrate the reported frequency of occurrence of dermatological side-effects or complications.
Conclusion: The top 100 prescribed medication cause a number of dermatological side effects that need to be considered when they are prescribed to patients who have pre-existing skin conditions. Additionally, when confronted with a common dermatological problem in any patient, clinicians should always consider the possibility of a drug adverse reaction.
IN VITRO ANTIBACTERIAL ACTIVITY OF MEDICINAL PLANTS TURMERIC, CHINNAMON, AND CLOVE AGAINST GM (+VE) AND GM (-VE) BACTERIA
Authors: MD ARIFUL ISLAM  , ISLAM MD SIDDIQUL , HOSSAIN MD ANWAR , AHMED SULTAN , AKTARUZZAMAN MD , AKANDA MD RASHEDUNNABI , HASAN TALHA MD MOWDUDUL , AL ZABIR ABDULLAH 
Published: September 2019

Objective: Various diseases are caused by different pathogenic microorganisms. Antibiotics are being used for treatment of these infectious diseases, yet unpredictable utilization of it leads towards antibacterial resistance. It is required to discover better approaches to battle against antibacterial resistance. Therefore, the study aimed to detect antibacterial sensitivity of ethanol extracts of Curcuma longa (turmeric), Cinnamomumzeylanicum (clove) and Syzygiumaromaticum (cinnamon) against Syaphylococcus aureus and E coli.
Methods: Prior to sensitivity testing, ethanol oils were extracted by an electric blender and each of the bacteria strains were cultured onto blood agar plate. Antibacterial activity was tested by agar well diffusion method where three different concentrations (50 μl, 75 μl and 100 μl) of selected plants extract were used so far as to measure the inhibition zone. Inhibition zone of the ethanol extract of these plants were calculated where three were found to be sensitive against Syaphylococcus aureus and E coli.
Results: Greater inhibition zone 14.5 mm, 18.25 mm, 21.5 mm at100 μl against Syaphylococcus aureus in case of cinnamon whereas the least inhibition zone was showed by turmeric and it was 9.00 mm, 11.00 mm, and 12.75 mm at 100 μl extract against E. coli.
Conclusion: Overall, all the ethanol extracts were found to effective against these two bacteria but cinnamon can be used as more effective antibacterial agent in both human and veterinary field after the toxicological test.
THE PROTECTIVE EFFECT OF THE CARTHMUS TINCTORIUS LEAVES EXTRACTON METHOTREXATE-INDUCED PULMONARY FIBROSIS IN RATS
Authors: KHADHEM HANAA SALMAN , MTHUWAINI MAHDI , MAJID WAJDY J. 
Published: September 2019

Objective: Pulmonary fibrosis (PF) is an irreversible and untreatable human disease encompasses a large group of chronic lung disorders associated with excessive remodeling, scarring, and fibrosis.
The current work was designed to study the harmful effects of methotrexate (MTX) administration on the lung and the possible protective role of Carthmus tinctorius leaves extract. The animals were utilized in this study.
Methods: A total of 40 male healthy adult Wistar albino rats with anaverage body weight of 200±25 g, were divided into four groups (10 animals each). G1: control group, G2: MTX group, G3: Carthamus tinctorius (CT), group G4:MTX+Carthamus tinctorius(CT). CT was administered orally at a dose of (40 mg/kg/day) for 4 w to G3 and G4. The (CT) group were performed to explore any toxic effect of the (CT) extract on the lung. Rats of G2 and G4 administered 4 mg/kg dose of MTX orally for 28 d. Rats of G1 were intraperitoneally (i. p) administered with normal saline 0.5 ml ∕ day for four weeks (4wk) to serveas control. The animals were weighed at the beginning, though, and at the end of experiments.
Results: The study showed that the relative lung weight was significantly increased at (P˂0.01) in MTX-treated animals in comparison to the control group. A combination of CT extract with MTX revealed significant decrease (P<0.01) in the lung relative weight in comparison to MTX group. Histopathological examination revealed that lung injury was less severe in group 3 and 4compared to group 2. The results indicated that CT significantly decreased collagen deposition, hydroxyproline content, and ameliorated pathological changes.
Conclusion: The study has clearly identified the importance protective role of CT extract on pulmonary fibrosis induced by methoxerate. We recommended CT as one of therapeutic strategy to amelioratethe lung fibrosis associated with methotrexate therapy.
Effectiveness of using an extensively hydrolyzed casein formula supplemented with
Lactobacillus rhamnosus
GG compared with an extensively hydrolysed whey formula in managing cow’s milk protein allergic infants
Authors: Guest Julian F , Fuller Graham W 
Published: September 2019

Aim:
To assess the comparative effectiveness of two hypoallergenic formulae in managing cow’s milk allergic infants.
Materials & methods:
This study retrospectively analyzed the case records of 940 formula-fed cow’s milk allergic infants in the UK extracted from The Health Improvement Network database.
Results:
At 24 months after starting a formula, 77% of infants fed an extensively hydrolyzed casein formula supplemented with
Lactobacillus rhamnosus
GG (eHCF LGG; n = 470) were estimated to have been successfully managed compared with 63% of matched infants who were fed an extensively hydrolyzed whey formula (eHWF; n = 470; p < 0.001). Additionally, significantly more eHWF-fed infants were estimated to be experiencing gastrointestinal symptoms, eczema and asthma (7.1 vs 3.1%; p < 0.02) at 24 months.
Conclusion:
First-line management of newly diagnosed cow’s milk allergic infants with eHCF LGG may slow down the allergic march seen in cow’s milk allergic children.
“Hacking in” Wikipedia Zero in Angola
Authors: Toupin Sophie 
Published: September 2019

Background A few years ago, a number of people in Angola were banned from editing Wikipedia Zero because they were concealing large files in the Wikimedia feature, from where the files could be shared in a private Facebook Zero group. Analysis To interpret this case study, the concept of “hacking in” is proposed as part of an open media and technological infrastructure. Conclusions and implications This short case study focuses on the ways in which users shape media infrastructure. These users tried to bypass the restricted conditions imposed on them first by a technology and a media ecology that increasingly resembles a walled-off garden and second by Wikipedia Zero’s associated discourse, which reinforced its designer’s intentions for the technology.
Associação Entre Doença Periodontal Materna e Parto Pré-termo e Baixo Peso ao Nascimento
Authors: OLIVEIRA Alcione Maria Soares Dutra de , OLIVEIRA Peterson Antônio Dutra de , COSTA Fernando De Oliveira , MANZI Flávio Ricardo , COSSO Maurício Greco 
Published: September 2019

Este estudo teve como objetivo avaliar a associação da condição periodontal materna na ocorrência de parto pré-termo e baixo peso ao nascimento de (PTBPN). Participaram do estudo 236 mulheres, com a média de 25 anos de idade e características socioeconômicas semelhantes, que deram à luz em uma instituição de saúde pública de Belo Horizonte (MG - Brasil). Os dados maternos, obstétricos e pediátricos foram obtidos nos prontuários médicos. O exame periodontal foi realizado no período de internação pós-parto, em seis sítios ao redor de todos os dentes presentes e incluiu a avaliação dos parâmetros clínicos profundidade de sondagem (PS), nível clínico de inserção (NIC) e sangramento à sondagem (SS). Para a análise considerou-se como caso
de doença periodontal a presença de um sítio com PS e NIC e” 4 mm. Não houve diferenças significantes quando da análise das variáveis raça, escolaridade, prematuridade prévia, diabetes, infecção geniturinária, consumo de álcool, hábito de fumar e doença periodontal. O teste Qui-quadrado mostrou significância estatística para os fatores de risco hipertensão (p=0,016) e consumo de drogas ilícitas (p=0,017). Já o teste t Student mostrou significância estatística para a variável idade (p=0,010). Na análise multivariada somente o consumo de drogas ilícitas mostrou-se significativo: elevou de 25% para 66,7% a ocorrência de
PTBPN. Esses resultados demonstraram que a condição periodontal materna não apresentou associação estatisticamente significativa com a ocorrência de PTBPN (p= 0,364).
Perfil dos pacientes da Clínica de Bebês da Universidade Federal de Santa Maria
Authors: Sandri Ana Paula Soares , Nakashima Brenda Lanza , Bresolin Carmela Rampazzo , Praetzel Juliana Rodrigues 
Published: September 2019

OBJETIVO:Traçar o perfil dos pacientes atendidos na Clínica de Bebês da UFSM.
MATERIAIS E MÉTODOS: A partir de um senso realizado entre março e julho de 2012, os dados foram retirados dos prontuários clínicos e socioeconômicos, totalizando uma amostra de 51 bebês (0 a 47 meses), residentes em Santa Maria-RSe região central do estado. A estatística empregada foi descritiva.
RESULTADOS: Os bebês envolvidos na pesquisa são em sua maioria meninos da raça branca, estão sob responsabilidade dos pais e moram com os mesmos, em residências de cinco cômodos, contendo três moradores, e cujo abastecimento é o de água tratada. As mães trabalham fora do ambiente familiar em metade dos casos, tendo, em sua maioria, segundo grau completo. A renda familiar mais frequente foi entre um e dois salários mínimos. Os pais realizam a escovação para seus filhos, duas vezes ao dia, utilizando creme dental. Houve predominância de bebês amamentados e que nunca haviam ido ao dentista. Com relação aos hábitos orais deletérios, 77,6% utilizam mamadeira, e destes, 59,2% utiliza dia e noite; 47,9% dos bebês fazem uso de chupeta e 25,5% sucção digital. No exame clínico, 96,8% dos bebês possuem dentição da série normal, 21,4% apresentam oclusopatias e 57,1% das crianças apresentam lesões cariosas.
CONCLUSÃO:A partir do perfil da população atendida, será possível direcionar os procedimentos que visam à manutenção e restabelecimento da saúde e definir os recursos necessários para sua execução.
PALAVRAS – CHAVE: Bebê. Saúde bucal. Qualidade de vida.
Preparo do canal radicular: proposta de metodologia para sua avaliação
Authors: LÓPEZ Fernanda Ullmann , VARGAS Gabriel Ferronato , IRALA Luis Eduardo , LIMONGI Orlando 
Published: September 2019

A avaliação das diferentes técnicas disponíveis de preparo de canais radiculares desempenha um importante papel na busca da otimização da terapia endodôntica. Buscando uma metodolgia que possibilitasse a análise comparativa do canal radicular antes e após sua instrumentação, apresenta-se um método, através de uma simples variação, baseada na proposta pioneira de BRAMANTE et al de 1987. Nessa proposta, a raiz/dente a serem estudados são incluídos em resina acrílica transparente autopolimerizável dentro de uma forma plástica (tubos de Eppendorf). Após a presa da resina, o bloco resina/raiz é removido da forma plástica e nele são confeccionados sulcos de localização. A seguir, este bloco é incluído numa mufla de gesso, tendo como molde um segmento plástico de condutor de fio elétrico. Desta forma, com os blocos de resina fixados e localizados no molde de gesso, pode-se realizar cortes seccionais, no sentido e altura desejada, que permitirão suas recolocações na mesma posição e o aparato permitirá suas imobilizações durante a operação.
Essa metodologia simples demonstrou eficiência, possibilitando análise de dentes monorradiculares ou raízes de polirradiculares antes e após a instrumentação do canal, possibilitando medições da quantidade de desgaste promovido.
CE Article: Transfer Rate of Pathogens Through In Vitro Contaminated Venous Port Membranes Varies With Species, Concentration, and Injection Technique
Authors: Taxbro Knut , Mernelius Sara , Hammarskjöld Fredrik , Hanberger Håkan , Berg Sören 
Published: September 2019

Highlights
Local SVP infection is a common and potentially avoidable complication. Local SVP infection is usually verified by cultures. The transfer rate of pathogens across the SVP membrane may be reduced by applying a positive-pressure flow technique when puncturing the membrane.