bluuebunny/crossref_metadata_2025_split huggingface dataset:
Shikonin protects mitochondria through the NFAT5/AMPK pathway for the treatment of diabetic wounds
Authors: Cen Lu-Sha , Cao Yi , Zhou Yi-Mai , Guo Jing , Xue Jing-Wen 
Published: November 2024

BACKGROUND
Shikonin is a natural remedy that is effective at treating diabetic wounds. NFAT5 is a potential therapeutic target for diabetes, and mitochondrial function is essential for wound healing. However, the relationship among Shikonin, NFAT5, and mitochondrial function has not been thoroughly studied. Here, we offer new perspectives on the advantages of shikonin for managing diabetes.
AIM
To assess the therapeutic mechanism of shikonin in diabetic wounds, its relationship with NFAT5, and its protection of mitochondrial function.
METHODS
Hypertonic cell and diabetic wound mouse models were established. NFAT5 expression was measured through western blotting and immunofluorescence, in vivo and in vitro . Mitochondrial function was evaluated using reactive oxygen species (ROS) detection and JC-1 and Calcein AM dyes. Mitochondrial structures were observed using transmission electron microscopy. The NFAT5/AMPK pathway was analyzed using a transfection vector and an inhibitor. The effect of shikonin on cells under hypertonic conditions via the NFAT5/AMPK pathway was assessed using western blotting.
RESULTS
Shikonin treatment preserved HaCaT cell viability, while significantly reducing cyclooxygenase-2 expression levels in a high-glucose environment (P < 0.05). Additionally, shikonin maintained mitochondrial morphology, enhanced membrane potential, reduced membrane permeability, and decreased ROS levels in HaCaT cells under hyperosmolar stress. Furthermore, shikonin promoted wound healing in diabetic mice (P < 0.05). Shikonin also inhibited NFAT5, in vivo and in vitro (P < 0.05). Shikonin treatment reduced NFAT5 expression levels, subsequently inhibiting AMPK expression in vitro (P < 0.05). Finally, shikonin inhibited several key downstream molecules of the NFAT5/AMPK pathway, including mammalian target of rapamycin, protein kinase B, nuclear factor kappa-light-chain-enhancer of activated B cells, and inducible nitric oxide synthase (P < 0.05).
CONCLUSION
Shikonin protects mitochondria via the NFAT5/AMPK-related pathway and enhances wound healing in diabetes.
NGHIÊN CỨU THÀNH PHẦN LOÀI VÀ PHÂN BỐ THÂN MỀM CHÂN BỤNG Ở CẠN (MOLLUSCA: GASTROPODA) KHU VỰC VEN BIỂN THÀNH PHỐ ĐÀ NẴNG
Authors: Nguyen Binh , Nguyễn Minh , Nguyễn Hảo , Trần Giang , Nguyễn Nhung 
Published: November 2024

Bài báo đề cập về kết quả nghiên cứu về thành phần loài Thân mềm Chân bụng ở cạn vùng ven biển thành phố Đà Nẵng được tiến hành vào 6/2022 – 10/2023. Qua phân tích đã xác định được 17 loài, trong số các loài được định danh có 15 loài có vỏ cứng để bảo vệ cơ thể, 2 loài sên trần (vỏ tiêu biến). Trong các loài được định danh có 13 loài đã được ghi nhận ở Quảng Nam - Đà Nẵng, mức độ đa dạng sinh học của các loài ở mức độ thấp (H’ = 1,2049). Bổ sung thành phần loài Thân mềm chân bụng ở cạn cho Đà Nẵng 4 loài (Aphanoconia hungerfordiana halongensis, Valiguna siamensis, Macrochlamys indica và Neotrachia duporti). Các loài Thân mềm Chân bụng ở cạn phân bố ở 3 loại sinh cảnh chính ở thành phố Đà Nẵng: Sinh cảnh bán đảo Sơn Trà có 6 loài với mật độ trung bình của tất cả các loài là 2,42 cá thể/m2; khu đông dân cư có 6 loài với mật độ trung bình của tất cả các loài là 11,67 cá thể/m2 và sinh cảnh Ngũ Hành Sơn có 11 loài với mật độ trung bình của tất cả các loài là 155,42 cá thể/m2.
An investigation into atmospheric nitrous acid (HONO) processes in South Korea
Authors: Kim Kiyeon , Han Kyung Man , Song Chul Han , Lee Hyojun , Beardsley Ross , Yu Jinhyeok , Yarwood Greg , Koo Bonyoung , Madalipay Jasper , Woo Jung-Hun , Cho Seogju 
Published: November 2024

Abstract. Nitrous acid (HONO) is a main precursor of hydroxyl radicals (OH), which contribute to the formation of numerous secondary air pollutants in the troposphere. Despite its importance in atmospheric chemistry, HONO chemistry has not been fully incorporated into many chemical transport models (CTMs). Due to the lack of atmospheric HONO processes, CTM simulations often tend to underestimate atmospheric mixing ratios of HONO. This study was undertaken because simulations with the current Community Multiscale Air Quality (CMAQ) model have a strong tendency to underestimate the HONO mixing ratio. In search of missing sources of atmospheric HONO, we attempted to sequentially incorporate the following potential HONO sources and processes into the CMAQ modeling framework: (i) gas-phase HONO reactions, (ii) traffic HONO emissions, (iii) soil HONO emissions, (iv) heterogeneous HONO production on the surfaces of aerosols, (v) heterogeneous HONO formation on tree leaf and building surfaces, and (vi) photolysis reactions of particulates and deposited HNO3/nitrates called “renoxification”. The simulation performances of the modified CMAQ models were then evaluated by comparing the modeled HONO mixing ratios with the HONO mixing ratios observed at the Olympic Park station in Seoul, South Korea. When HONO processes were fully added to the CMAQ model, average daily HONO mixing ratios increased from 0.06 to 1.18 ppb. The daytime HONO mixing ratios produced from the CMAQ model run with a full account of atmospheric HONO processes were found to be in better agreement with observations than those from the original CMAQ model (CMAQv5.2.1) runs with improved statistical metrics (e.g., the index of agreement (IOA) increased from 0.59 to 0.68, while the mean bias (MB) decreased dramatically from −0.57 to −0.34 ppb). In addition, we investigated the contributions of individual atmospheric HONO processes to HONO mixing ratios, as well as the impacts of HONO atmospheric processes on the concentrations of other atmospheric species in South Korea. All these issues are also discussed in this paper.
System monitoring of solar power plant using NODE MCU ESP8266 based on IOT
Authors: Limbong Fitrah Hasan , Taufiq T , Bintoro A 
Published: November 2024

Solar Power Plants (PLTS) have become a very popular energy source and have great potential in reducing dependence on fossil energy sources. The Node MCU ESP8266 is one type of microcontroller that is highly popular in the development of IoT projects. In generating electrical energy, the Internet of Things (IoT) technology has rapidly developed and become one of the most popular technologies in the field of electrical energy. With a PLTS monitoring system using a website, users can monitor the performance of the PLTS in real-time. Solar panels or solar cells are equipment modules that can convert solar energy into electrical energy with DC current. Monitoring is the process of systematically and continuously collecting and analyzing information based on predetermined indicators of activities/programs, allowing corrective actions to be taken for the improvement of the program/activity. The researchers will also discuss the importance of monitoring PLTS, as well as the potential of IoT technology to improve the efficiency and quality of electrical energy production. The website is used to operate IoT principles designed for fast and easy real-time reading. Functional testing is divided into three parts: voltage sensor testing, ACS712 current sensor testing, and NodeMCU testing. The electrical parameters to be measured include output current and output voltage. The PLTS monitoring system device, also known as the Box Panel, has been designed, built, and tested. The testing phase is carried out by conducting functional tests on the system to determine the success rate and accuracy of the device. Once the box panel functions properly, it can be used to monitor the output of the PLTS, and the measurement results will be displayed on the website that has been created.
Penerapan Model Discovery Terbimbing Pada Pembelajaran Geografi Untuk Meningkatkan Hasil Belajar Siswa Kelas X di SMA Negeri 5 Toraja Utara
Authors: Panggalo Irra , Andaria Kalvin Salindeho , Rifani Irfan 
Published: November 2024

This research aims to determine the effect of implementing the guided discovery model on class X geography learning at SMA Negeri 5 Toraja Utara. The research method used is a quantitative method. The research location is at SMA Negeri 5 Toraja Utara. Data collection techniques are observation, tests and documentation. The population in the research is class X with a total of 96 students and the sample is 20 people. The data analysis technique used is descriptive and inferential statistical analysis. The results of the research show that the value of tcal is 12.98 and ttable is 2.10092, tcal>ttable= 12.98 >2.10092. At the Sig α level there is a test of 2 variables with the result at t0.05 value ttable= 2.10092, so it can be concluded that H0 is rejected and H1 is accepted, which means that the guided discovery model has a positive influence in improving the geography result at SMA Negeri 5 Toraja Utara.
Позднесоветская литература об этнических депортациях в полемике с советским романом воспитания
Authors: М. Майофис , И. Кукулин 
Published: November 2024

В русской литературе 1980-х были сформированы несколько моделей постколониального и посттравматического романа воспитания (Bildungsroman), которые были «вытеснены» (в психоаналитическом смысле) и забыты в ходе постсоветских трансформаций исторического сознания общества. В этой статье обсуждаются две повести: «Декада» Семена Липкина (1979—1980) и «Ночевала тучка золотая» Анатолия Приставкина (1981). В центре сюжета обеих этих повестей — депортации народов Северного Кавказа, осуществленные по решению Сталина и советского руководства в 1944 году: у Приставкина речь идет о чеченцах, у Липкина — о вымышленном народе тавларов, обобщающем черты нескольких депортированных этносов. Оба произведения имеют гибридную жанровую природу, и в обоих авторы независимо друг от друга переосмысляют элементы классического и советского Bildungsroman — так, что обе повести имеют значимые параллели с англоязычными постколониальными романами воспитания, созданными в начале XXI века. Анализируя повесть Липкина, мы специально останавливаемся на значении декад литературы и искусства — важной формы парадной репрезентации «дружбы народов», необходимой для осуществления советской национальной политики.
Authors of Russophone literature of the 1980s elaborated one or more models of the postcolonial and post-traumatic Bildingsroman, which were “suppressed” (in Freudian sense) and forgotten in the course of the post-Soviet transformations of society’s historical consciousness. This paper discusses two novellas: The Decade by Semyon Lipkin (1983) and The Inseparable Twins by Anatoly Pristavkin (1981). The basis of both novellas’ plots is deportation of the peoples of the North Caucasus, initiated by Stalin and the other Soviet leadership in 1944: Pristavkin’s story concerns the Chechens, Lipkin’s one — the fictional nation of Tavlars, which summarizes the features of several deported ethnic groups. Both works are of a hybrid genre, and both authors independently revisit elements of the classical and Soviet Bildungsroman, so that their novellas have significant parallels with English-language postcolonial Bildungsromans created at the beginning of the 21st century. When analyzing Lipkin’s novella, we particularly discuss the significance of “decades of literature and art” — an important form of ceremonial representation of the “friendship of peoples” necessary for the implementation of Soviet national politics.
«Зачем люди друг друга убивают?» (Толстой и империя)
Authors: А. Зорин 
Published: November 2024

В статье показано, что взгляды на войну Толстого в начале и в конце его творческого пути отличались скорее нюансами и акцентами, чем по существу. понять кавказские рассказы и «Войну и мир» — значит увидеть в них зерна толстовской философии непротивления злу насилием и его последовательно антиимперской позиции, а осмыслить наследие Толстогопацифиста невозможно, не уяснив его отношение к насилию как к важнейшей составляющей человеческой природы. Толстой неизменно считал, что защита от захватчиков земли, на которой стоит дом человека, плодами которой он кормится и в которую он ляжет после смерти, укоренена в природном цикле человеческой жизни. Такое отношение к насилию было для Толстого естественным, но доморальным, дохристианским, противоречащим личному нравственному чувству, безусловно противящемуся любым убийствам.
The article shows that Tolstoy’s perception of the war in the beginning and in the end of his creative career differed rather in nuances and accents than in content. Understanding of his early stories and War and Peace implies seeing here the germs of Tolstoy’s consistent anti-militarist and anti-imperial stance while the heritage of Tolstoy’s the pacifist cannot be fully interpreted without considering his view of violence as an integral part of human nature. Tolstoy always believed that the resistance to invaders and the defence of land where humans were born, by which products they are fed and where they are going to life after death is natural, but considered this instinct as pre-moral and pre-Christian contradicting the personal moral conscience that unconditionally rejects all sorts of violence.
ВОПРОСЫ ЦИФРОВОЙ ТРАНСФОРМАЦИИ В ТРАСПОРТНОЙ ОТРАСЛИ: АКТУАЛИЗАЦИЯ РАЗВИТИЯ СПРОСА НА ЦИФРОВЫЕ ТЕХНОЛОГИИ
Authors: К.В. Борзенко 
Published: November 2024

Предметом выступает уточнение ситуации с глубиной цифровых преобразований в отрасли транспорта в России и имеющихся в данном отношении перспективах. Целью статьи является детализация прогноза прироста спроса на цифровые технологии в отрасли транспорта с детерминацией возможных барьеров и направлений их преодоления. Метод: сопоставление мнений экспертов, специализированных организаций в отношении глубины цифровых изменений в отрасли транспорта, анализ реализованных проектов, оценка тренда прироста спроса на цифровые технологии в отрасли. Результаты статьи имеют прикладное значение, они состоят в обосновании преобразований инфраструктуры, развития нормативных требований и предоставления финансовой помощи в виде активизации льготных кредитов для малых и средних предпринимателей, предприятий, которые успешно внедрили и/или разработали востребованные цифровые решения, возможные к масштабированию в отрасли.
Subject is to clarify the situation with depth of digital transformations in transport industry in Russia and prospects available in this regard. Purpose of article is to detail the forecast of increase in demand for digital technologies in transport industry with determination of possible barriers and ways to overcome them. Method: comparison of opinions of experts, specialized organizations regarding the depth of digital changes in transport industry, analysis of implemented projects, assessment of trend of growth in demand for digital technologies in industry. Results of work are of applied importance, they consist in substantiating infrastructure transformations, development of regulatory requirements and provision of financial assistance in form of activation of preferential loans for small and medium-sized entrepreneurs, enterprises that have successfully implemented and/or developed in-demand digital solutions that can be scaled in industry.
РАЗВИТИЕ ЛОГИСТИЧЕСКОЙ СИСТЕМЫ ВЕТРОЭНЕРГЕТИКИ В РОСТОВСКОЙ ОБЛАСТИ
Authors: М.А. Мацедонский 
Published: November 2024

В статье охарактеризовано моделирование процесса развития логистической системы ветроэнергетики на юге России, проанализирована ситуация с несколькими функционирующими а также проектируемыми для возведения в будущем в эксплуатацию ветропарками в Ростовской области; представлено мнение, согласно которому новые объекты генерации на основе возобновляемых источников энергии, должны заполнить выбытие устаревших фондов; рассмотрены новые фонды генерации смежных регионов а так же перспективы развития логистической системы ветроэнергетики на исследуемой территории.
Article describes the modeling process of development of wind energy logistics system in south of Russia, analyzes the situation with several functioning and projected for future construction of wind farms in Rostov region; presented the view that new generation facilities based on renewable energy sources, should fill the retirement of obsolete funds; considered new generation funds adjacent regions as well as prospects for development of logistics system of wind energy in study area.
РЕГУЛЯТОРЫ ЗЕРНОВОГО РЫНКА РОССИЙСКОЙ ФЕДЕРАЦИИ В 2023 Г.
Authors: Т.А. Салтанова , И.А. Митина 
Published: November 2024

Регулирование зернового рынка страны представляет собой дискуссионный вопрос, поскольку затрагивает интересы всех участников национальной агропродовольственной системы. Необходимо соблюдение таких зависимостей, как обеспечение продовольственной безопасности страны и экспорт зерна, увеличение доходности зернового сектора и стимулирование развития животноводства. Несбалансированность данных процессов негативно отражается на достижении целевых установок в развитии агропромышленного комплекса в целом. В статье рассмотрены основные аспекты регулирования зернового рынка России в ситуации расширения предложения, роста затрат растениеводов. Статья посвящена практическим вопросам функционирования и регулирования зернового рынка в условиях расширенного предложения, стабилизации цен на уровне предшествующих периодов без учета роста затрат производителей. Обоснована необходимость применения административных и экономических регуляторов зернового рынка в целях повышения эффективности его функционирования и поступательного развития всей агропродовольственной системы.
Regulation of country's grain market is debatable issue, since it affects the interests of all participants in national agro-food system. It is necessary to comply with such dependencies as ensuring the country's food security and grain exports, increasing the profitability of grain sector and stimulating the development of animal husbandry. Imbalance of these processes negatively affects the achievement of targets in development of agro-industrial complex as a whole. Article examines the main aspects of regulating the grain market of Russia in situation of expanding supply, rising costs of plant growers. Article is devoted to practical issues of regulating the functioning and regulation of grain market in conditions of expanded supply, price stabilization at the level of previous periods without taking into account the growth of producers' costs. Necessity of applying administrative and economic regulators of grain market in order to increase the efficiency of its functioning and progressive development of entire agro-food system is substantiated.
SOLUSI PENANGANAN PENCEMARAN AIR SUNGAI AKIBAT SISTEM SANITASI YANG BURUK DI KAMPUNG ANYAR, BULELENG,BALI
Authors: I Wayan Selva Paryanta , Tamiarta Kori , Pradnyaningrum Siskha 
Published: November 2024

Kampung Anyar merupakan salah satu dari 8 permukiman yang ditetapkan sebagai permukiman kumuh di kabupaten Buleleng menurut surat keputusan bupati Nomor 050/74/HK/2016. Tergolongnya sebagai permukiman kumuh dikarenakan karakteristik dan permasalahan-permasalahan permukiman kumuh ada pada Kampung Anyar ini, baik secara fisik maupun non fisik. Lokasi yang berdekatan dengan pantai/laut menyebabkan posisi air tanah menjadi lebih tinggi, sekitar 2 meter dari permukaan tanah sehingga warga kesulitan dalam membuat saluran pembuangan tinja dan tidak memungkinkan untuk penggalian septik tank. Maka warga di kampung anyar menggunakan toilet umum yang posisinya berada di atas sungai dan tinja/kotoran manusia akan langsung dibuang ke sungai, sehingga menimbulkan pencemaran terhadap lingkungan sungai. Maka dari itu, tujuan dari penulisan jurnal ini adalah untuk memberikan solusi dari permasalahan sanitasi (septic tank) tersebut dan sistem pembuangan yang lebih ramah lingkungan. Metoda penelitian yang digunakan adalah kualitatif dengan cara pengumpulan data melalui survei lapangan, wawancara dan studi literatur, serta metoda analisis menggunakan pendekatan kualitatif. Hasil dari penelitian ini adalah penggunaan septic tank biofilter, dimana posisinya tidak perlu terlalu dalam sehingga masih aman dari air tanah dan untuk meminimalkan dampak terhadap lingkungan, karena menggunakan metode pengolahan aerob / anaerob dengan sistem filtrasi, yang memungkinkan tinja diolah dan diurai di dalam tabung septic tank biofil tanpa memerlukan rembesan seperti septic tank konvensional biasa, sehingga air tanah maupun air sungai tidak tercemar.
Major considerations of gingivoplasty: a concise systematic review
Authors: Evangelista Iasmim Milene , Candido Lauani Regina , Araújo José Janci Siqueira de , Scriboni Andreia Borges 
Published: November 2024

Introduction: In the scenario of gingivoplasty, well-being is directly related to health, people with a balanced smile, between health and beauty, tend to smile more and this generates a condition of well-being. In gingival correction, process-specific techniques are used for each case, thus individualizing the patient and the proposed treatment, correcting not only the aesthetics but also the patient as a whole. Objective: This systematic review study described the techniques used to correct a gummy smile, with the gingivoplasty technique being selected. Methods: The PRISMA Platform systematic review rules were followed. The search was carried out from March to June 2024 in the Scopus, PubMed, Science Direct, Scielo, and Google Scholar databases. The quality of the studies was based on the GRADE instrument and the risk of bias was analyzed according to the Cochrane instrument. Results and Conclusion: 78 articles were found and 15 articles were evaluated in full and 06 were included and developed in the present systematic review study. Considering the Cochrane tool for risk of bias, the overall assessment resulted in 25 studies with a high risk of bias and 22 studies that did not meet GRADE and AMSTAR-2. Most studies did not show homogeneity in their results, with X2=87.5%>50%. It was concluded that applications of injectable platelet-rich fibrin have shown positive effects on epithelial wound healing after gingivectomy and gingivoplasty operations. A patient with a meso facial profile, compatible with hypertonic lips, improves our favorable prognostic acceptability with a lower risk of relapse and dissatisfaction. Bone-removing gingivoplasty is indicated for cases where removal of the gingival band only reduces the gingival sulcus invading the biological distance and thus needs to remove the bone for soft tissue stability.