bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Association Between Sequential Organ Failure Assessment Scores and Mortality in Patients With Sepsis During the First Week: The JSEPTIC DIC Study
Authors: Nakashima Tsuyoshi , Miyamoto Kyohei , Shimokawa Toshio , Kato Seiya , Hayakawa Mineji 
Published: May 2018

Objective: Predicting prognosis is a complex process, particularly in patients with severe sepsis or septic shock. This study aimed to determine the relationship between the Sequential Organ Failure Assessment (SOFA) scores for individual organs during the first week of admission and the in-hospital mortality in patients with sepsis. Methods: This study was a post hoc evaluation of the Japan Septic Disseminated Intravascular Coagulation study and included patients admitted to 42 intensive care units in Japan for severe sepsis or septic shock, between January 2011 and December 2013. We assessed the relationship between the organ and total SOFA scores on days 1, 3, and 7 following admission and the in-hospital mortality using logistic regression analysis. Results: We evaluated 2732 patients and found the in-hospital mortality rate was 29.1%. The mean age of the patients (standard deviation) was 70.5 (14.1) years, and the major primary site of infection was the abdomen (33.6%). The central nervous system (CNS) SOFA score exhibited the strongest relationship with mortality on days 1 (adjusted odds ratio [aOR]: 1.49, 95% confidence interval [CI]: 1.40-1.59), 3 (aOR: 1.75, 95% CI: 1.62-1.89), and 7 (aOR: 1.93, 95% CI: 1.77-2.10). The coagulation SOFA scores showed a weak correlation with mortality on day 1, but a strong correlation with mortality on day 7 (aOR: 2.04, 95% CI: 1.87-2.24). Conclusions: The CNS SOFA scores were associated with mortality in patients with severe sepsis on days 1, 3, and 7 following hospitalization. The coagulation SOFA score was associated with mortality on day 7. In clinical situations, the CNS SOFA scores during the acute phase and the CNS SOFA and coagulation SOFA scores during the subsequent phases should be evaluated in order to determine patient prognosis.
Simultaneous Intraoperative Measurement of Cadaver Ankle and Subtalar Joint Compression During Arthrodesis With Intramedullary Nail, Screws, and Tibiotalocalcaneal Plate
Authors: Hamid Kamran S. , Glisson Richard R. , Morash Joel G. , Matson Andrew P. , DeOrio James K. 
Published: May 2018

Background: Suboptimal tibiotalocalcaneal arthrodesis (TTCA) fusion rates may result from inadequate compression that increases motion and interferes with bony bridging. The aim of this study was to evaluate compressive forces at the ankle and subtalar joints with 3 contemporary TTCA constructs. Methods: Thirty fresh-frozen cadaveric lower extremity specimens were divided into 3 groups of 10 each: 3 partially threaded cannulated screws, hindfoot nail, and lateral plate. Specimens were mounted to a testing apparatus, and compression was independently measured at the tibiotalar and talocalcaneal interfaces. Statistical analysis included paired Student t tests, analysis of variance, and Tukey post hoc tests. Results: Mean forces at the ankle joint for the screws, nail, and plate constructs were 331 ± 86, 479 ± 137, and 548 ± 199 N, respectively, with plates providing significantly more compression than screws ( P < .01). Similarly, subtalar compressive forces demonstrated 319 ± 105 N in the screws group, 466 ± 125 N, in the nail group, and 513 ± 181 N in the plate group, with plate compression greater than that achieved with screws ( P < .01). No differences were identified in compression between ankle and subtalar joints within specimens in any group. Conclusions: Lateral TTCA plates provided increased compressive forces at the ankle and subtalar joint compared with screws-only constructs. Hindfoot nails did not demonstrate significant differences in either of these parameters compared with plates or screws in this study. Clinical Relevance: Hindfoot nail and lateral plate options should be strongly considered when aiming to maximize compression in patients undergoing TTCA.
Wound and Sural Nerve Complications of the Sinus Tarsi Approach for Calcaneus Fractures
Authors: Li Shaoliang 
Published: May 2018

Background The purpose of this study was to evaluate the optimal timing and measures of the sinus tarsi approach for calcaneus fractures to avoid iatrogenic injury of the sural nerve and to assess for wound complications. Methods: A case series of 53 patients with calcaneus fractures treated by a single surgeon with the sinus tarsi approach was retrospectively analyzed. On the basis of the delay time from injury to surgery, patients were classified into 4 groups: immediate (0–3 days), early (4–6 days), intermediate (7–14 days), and late (14–18 days). All patients were followed for at least 1 year to observe wound conditions. The rate of wound complications and iatrogenic sural nerve injury was described. Incisions were classified into 2 groups: group A included patients with incisions extending posterior to the lateral malleolus, and group B included patients with incisions confined anterior to the lateral malleolus. The rates of nerve injury were compared between both groups. Forty-three patients with 52 Sanders type II fractures were included. Results: The average time to surgery from injury was 8.8 days (range, 0–18 days). The overall postoperative rate of wound complications was 5.8% (3 of 52). In the immediate group, deep infections and wound necrosis were found in 2 of 8 fractures (25%). In the early group, 1 of 15 fractures developed superficial infection (6.7%). In the intermediate and late groups, no wound complication was identified. Iatrogenic sural nerve injury was recorded in 5 of 52 patients (9.6%). Group A had 33% (4 of 12) nerve injuries and group B had 2.5% (1 of 40) ( P = .009). In 70% of cases, a main branch of the sural nerve was directly under the incision. Conclusions: The sinus tarsi approach was generally effective and safe for calcaneus fractures. However, it was relatively risky to perform open reduction and internal fixation by the sinus tarsi approach within 6 days of injury. Because the sural nerve is in the vicinity of the approach, iatrogenic injury should be avoided by the use of careful planning and meticulous manipulations. Level of Evidence Therapeutic; Level III, comparative study.
Medical management of deep ulcerative keratitis in cats: 13 cases
Authors: Martin de Bustamante Michelle G , Good Kathryn L , Leonard Brian C , Hollingsworth Steven R , Edwards Sydney G , Knickelbein Kelly E , Cooper Ann E , Thomasy Sara M , Maggs David J 
Published: May 2018

Case series summary Described are 13 cats diagnosed with deep ulcerative keratitis and successfully managed medically without grafting procedures. Typical treatment involved frequent topical application of serum and antibiotics (usually a fluoroquinolone and a cephalosporin). Seven cats also received systemic antibiotics. Analgesia was achieved using various combinations of topical atropine and systemic buprenorphine, robenacoxib or corticosteroids. Six cats were hospitalized for a median (range) period of 2.5 (1–8) days, typically because of frequent medication administration. Median (range) follow-up time was 41.5 (9–103) days. Median (range) number of recheck examinations was 4 (2–6). Median (range) time to corneal re-epithelialization was 21 (9–103) days. Median (range) topical antibiotic course was 29.5 (16–103) days. Median (range) duration of Elizabethan collar use was 28 (13–73) days. At the time of writing, no further recheck examinations were recommended for 10 cats; median (range) time between initial to final examinations in these cats was 35 (20–103) days. All cats retained the affected globes and were apparently comfortable and visual at the latest recheck examination. Relevance and novel information These cases reveal that aggressive medical management is highly successful in select cats with deep ulcerative keratitis, and can result in a cosmetically acceptable, apparently comfortable and visual globe. However, therapy is intensive with frequent administration of multiple topical and sometimes systemic medications, and requires multiple veterinary visits over many weeks. Referral to a veterinary ophthalmologist for consideration of surgical stabilization is recommended, as not all cases may be amenable to the medical therapy described here.
Characteristics and survival data from Latvian pulmonary hypertension registry: comparison of prospective pulmonary hypertension registries in Europe
Authors: Skride Andris , Sablinskis Kristaps , Lejnieks Aivars , Rudzitis Ainars , Lang Irene 
Published: May 2018

Patient registries are a valuable tool in the research of rare conditions such as pulmonary hypertension (PH). We report comprehensive hemodynamic and survival data of 174 patients with pulmonary arterial hypertension (PAH) and chronic thromboembolic pulmonary hypertension (CTEPH), included in the prospective Latvian PH registry over a period of > 9 years. In total, 130 adult PAH patients (75%) and 44 adult CTEPH patients (25%) were enrolled. The median follow‐up period was 33 months for PAH and 18 months for CTEPH, P = 0.001. Latvian CTEPH patients had significantly higher plasma levels of B‐type natriuretic peptide, higher pulmonary vascular resistance, and lower cardiac index than Latvian PAH patients. Calculated incidence of PAH and CTEPH in Latvia in 2016 was 13.7 and 5.1 cases per million inhabitants, calculated prevalence was 45.7 and 15.7 cases per million inhabitants, respectively. Survival rates at one, three, and five years for PAH patients was 88.0%, 73.3%, and 58.1%, and 83.8%, 59.0%, and 44.2% for CTEPH patients, respectively. We compared our study results with data from European adult PH registries. Latvian PAH patients had the fourth lowest and CTEPH patients the lowest one‐year survival rate among European adult PH registries. As most PH registries in Europe are small, yet with equivalent patient inclusion criteria, it would be desirable to combine these registries to produce more reliable and high‐quality study results.
miR-29c plays a suppressive role in breast cancer by targeting the TIMP3/STAT1/FOXO1 pathway
Authors: Li Wan , Yi Jie , Zheng Xiangjin , Liu Shiwei , Fu Weiqi , Ren Liwen , Li Li , Hoon Dave S. B. , Wang Jinhua , Du Guanhua 
Published: May 2018

Abstract
Background
miR-29c has been associated with the progression of many cancers. However, the function and mechanism of miR-29c have not been well investigated in breast cancers.

Methods
Real-time quantitative PCR was used to assess expression of miR-29c and DNMT3B mRNA. Western blot and immunochemistry were used to examine the expression of DNA methyltransferase 3B (DNMT3B) protein in breast cancer cells and tissues. The functional roles of miR-29c in breast cancer cells such as proliferation, migration, invasion, colony formation, and 3D growth were evaluated using MTT, transwell chambers, soft agar, and 3D Matrigel culture, respectively. In addition, the luciferase reporter assay was used to check if miR-29c binds the 3′UTR of DNMT3B. The effects of miR-29c on the DNMT3B/TIMP3/STAT1/FOXO1 pathway were also examined using Western blot and methyl-specific qPCR. The specific inhibitor of STAT1, fludarabine, was used to further check the mechanism of miR-29c function in breast cancer cells. Studies on cell functions were carried out in DNMT3B siRNA cell lines.

Results
The expression of miR-29c was decreased with the progression of breast cancers and was closely associated with an overall survival rate of patients. Overexpression of miR-29c inhibited the proliferation, migration, invasion, colony formation, and growth in 3D Matrigel while knockdown of miR-29c promoted these processes in breast cancer cells. In addition, miR-29c was found to bind 3′UTR of DNMT3B and inhibits the expression of DNMT3B, which was elevated in breast cancers. Moreover, the protein level of TIMP3 was reduced whereas methylation of TIMP3 was increased in miR-29c knockdown cells compared to control. On the contrary, the protein level of TIMP3 was increased whereas methylation of TIMP3 was reduced in miR-29c-overexpressing cells compared to control. Knockdown of DNMT3B reduced the proliferation, migration, and invasion of breast cancer cell lines. Finally, our results showed that miR-29c exerted its function in breast cancers by regulating the TIMP3/STAT1/FOXO1 pathway.

Conclusion
The results suggest that miR-29c plays a significant role in suppressing the progression of breast cancers and that miR-29c may be used as a biomarker of breast cancers.
Manufacture and physical properties of the denim fabrics using Hanji paper yarn as weft yarn
Authors: Park Tae Young , Kim Myoung-Ok 
Published: May 2018

AbstractThis study aims to develop the Hanji denim fabric with Hanji combination yarn or with the Hanji paper yarn and core spun yarn in a 1:1 ratio as a weft. For the weft yarn, chemical indigo and natural indigo dyestuffs were used. The study developed four kinds of Hanji paper yarns and eight kinds of Hanji denim fabrics. In addition, the study tested the properties of the developed Hanji paper yarns, Hanji denim fabrics, and existing denim fabrics. In regard to the physical properties of yarns, the Hanji paper yarn showed a lower breaking stress but a relatively high breaking strain, and it remained a stable structure with no surface fluff. The Hanji combination yarn improved the weaving ability and had a stable structure form. In the resulting physical properties of the developed Hanji denim fabrics, they had a low apparent specific gravity, stability in dimensional change in washing and drying, a higher chance of commercialization in colorfastness to washing, medium stretchability, a similar drying velocity, and a fast absorption velocity compared to the existing denim fabrics. The study suggests that the Hanji denim fabrics are the good candidate materials for summer product development, since generally the Hanji denim fabrics have cool characteristics with the excellent absorption velocity, drying velocity, and low specific gravity.
Exploratory Analysis of Brigatinib Activity in Patients With Anaplastic Lymphoma Kinase-Positive Non–Small-Cell Lung Cancer and Brain Metastases in Two Clinical Trials
Authors: Camidge D. Ross , Kim Dong-Wan , Tiseo Marcello , Langer Corey J. , Ahn Myung-Ju , Shaw Alice T. , Huber Rudolf M. , Hochmair Maximilian J. , Lee Dae Ho , Bazhenova Lyudmila A. , Gold Kathryn A. , Ou Sai-Hong Ignatius , West Howard L. , Reichmann William , Haney Jeff , Clackson Tim , Kerstein David , Gettinger Scott N. 
Published: May 2018

Purpose In patients with crizotinib-treated, anaplastic lymphoma kinase gene ( ALK)-rearranged non–small-cell lung cancer (ALK-positive NSCLC), initial disease progression often occurs in the CNS. We evaluated brigatinib, a next-generation ALK inhibitor, in patients with ALK-positive NSCLC with brain metastases. Patients and Methods Patients with ALK-positive NSCLC received brigatinib (90 to 240 mg total daily) in a phase I/II trial (phI/II; ClinicalTrials.gov identifier: NCT01449461) and in the subsequent randomized phase II trial ALTA (ALK in Lung Cancer Trial of AP26113; ClinicalTrials.gov identifier: NCT02094573; patients in arm A received 90 mg once daily; patients in arm B received 180 mg once daily with 7-day lead-in at 90 mg). Primary end points (systemic objective response rates [ORRs]) were previously reported. Independent review committees assessed intracranial efficacy in patients with baseline brain metastases. Results Most patients with ALK-positive NSCLC had baseline brain metastases (50 of 79 [63%], phI/II; 80 of 112 [71%] and 73 of 110 [66%] in ALTA arms A and B, respectively), many of whom had no prior brain radiotherapy (23 of 50 [46%], phI/II; 32 of 80 [40%], ALTA arm A; 30 of 73 [41%], arm B). All patients, except four in phI/II, had received crizotinib. Among patients with measurable (≥ 10 mm) brain metastases, confirmed intracranial ORR was 53% (eight of 15; 95% CI, 27% to 79%) in phI/II, 46% (12 of 26; 95% CI, 27% to 67%) in ALTA arm A, and 67% (12 of 18; 95% CI, 41% to 87%) in arm B. Intracranial ORRs were similar in subsets without prior radiation or progression postradiation. Among patients with any baseline brain metastases, median intracranial progression-free survival (iPFS) was 14.6 months (95% CI, 12.7 to 36.8 months), phI/II; 15.6 months (95% CI, 9.0 to 18.3 months), ALTA arm A; 18.4 months (95% CI, 12.8 months to not reached), ALTA arm B. Conclusion Brigatinib yielded substantial intracranial responses and durable iPFS in ALK-positive, crizotinib-treated NSCLC, with highest iPFS in patients receiving 180 mg once daily (with lead-in).
RNA Profiles of Circulating Tumor Cells and Extracellular Vesicles for Therapy Stratification of Metastatic Breast Cancer Patients
Authors: Keup Corinna , Mach Pawel , Aktas Bahriye , Tewes Mitra , Kolberg Hans-Christian , Hauch Siegfried , Sprenger-Haussels Markus , Kimmig Rainer , Kasimir-Bauer Sabine 
Published: May 2018

Abstract

BACKGROUND
Liquid biopsies are discussed to provide surrogate markers for therapy stratification and monitoring. We compared messenger RNA (mRNA) profiles of circulating tumor cells (CTCs) and extracellular vesicles (EVs) in patients with metastatic breast cancer (MBC) to estimate their utility in therapy management.

METHODS
Blood was collected from 35 hormone receptor-positive/HER2-negative patients with MBC at the time of disease progression and at 2 consecutive staging time points. CTCs were isolated from 5 mL of blood by positive immunomagnetic selection, and EVs from 4 mL of plasma by a membrane affinity-based procedure. mRNA was reverse transcribed, preamplified, and analyzed for 18 genes by multimarker quantitative polymerase chain reaction (qPCR) assays. RNA profiles were normalized to healthy donor controls (n = 20), and results were correlated with therapy outcome.

RESULTS
There were great differences in mRNA profiles of EVs and CTCs, with only 5% (21/403) of positive signals identical in both fractions. Transcripts involved in the PI3K signaling pathway were frequently overexpressed in CTCs, and AURKA, PARP1, and SRC signals appeared more often in EVs. Of all patients, 40% and 34% showed ERBB2 and ERBB3 signals, respectively, in CTCs, which was significantly associated with disease progression (P = 0.007). Whereas MTOR signals in CTCs significantly correlated with response (P = 0.046), signals in EVs indicated therapy failure (P = 0.011). The presence of AURKA signals in EVs seemed to be a marker for the indication of unsuccessful treatment of bone metastasis.

CONCLUSIONS
These results emphasize the potential of CTCs and EVs for therapy monitoring and the need for critical evaluation of the implementation of any liquid biopsy in clinical practice.
INDUSTRI 4.0: TELAAH KLASIFIKASI ASPEK DAN ARAH PERKEMBANGAN RISET
Authors: Prasetyo Hoedi , Sutopo Wahyudi 
Published: May 2018

AbstrakIstilah Industri 4.0 lahir dari ide tentang revolusi industri keempat. Keberadaannya menawarkan banyak potensi manfaat. Guna mewujudkan Industri 4.0, diperlukan keterlibatan akademisi dalam bentuk riset. Artikel ini bertujuan untuk menelaah aspek dan arah perkembangan riset terkait Industri 4.0. Pendekatan yang digunakan adalah studi terhadap beragam definisi dan model kerangka Industri 4.0 serta pemetaan dan analisis terhadap sejumlah publikasi. Beberapa publikasi bertema Industri 4.0 dipilah menurut metode penelitian, aspek kajian dan bidang industri. Hasil studi menunjukkan Industri 4.0 memiliki empat belas aspek. Ditinjau dari metode penelitian, sebagian besar riset dilakukan melalui metode deskriptif dan konseptual. Ditinjau dari aspeknya, aspek bisnis dan teknologi menjadi fokus riset para peneliti. Ditinjau dari bidang industri penerapannya, sebagian besar riset dilakukan di bidang manufaktur. Ditinjau dari jumlahnya, riset terkait Industri 4.0 mengalami tren kenaikan yang signifikan. Artikel ini diharapkan dapat memberi gambaran mengenai apa itu Industri 4.0, perkembangan dan potensi riset yang ada di dalamnya. AbstractIndustry 4.0: Study of Aspects Classification and Future Research Direction. The term Industrial 4.0 refers to the idea about fourth industrial revolution. In order to realize Industry 4.0, academic involvement is required in the form of research. This article aims to define the aspects and future direction of research related to Industry 4.0. Literature review of various definition and concept models of Industry 4.0. was conducted to acquire the aspects. Mapping and analysis of several publications were conducted to determine the future direction of research. Publications were sorted according to research methods, aspects and type of industry. The result shows that Industry 4.0 has fourteen aspects. Based on research methods, most of the research is done through descriptive and conceptual methods. Business and technology aspects become the focus of the researchers and most of the research is done in manufacturing industry. Based on quantities, Industrial 4.0 research has experienced a significant upward trend. This article is expected to illustrate the concept, future development and research trend of Industry 4.0.Keywords: Industry 4.0; Literature Review; Research Trend
Identification of Compounds Released During Pyrolysis of Palm Kernel Shell (PKS) Using Pyrolysis-GC/MS
Authors: Mansur Dieni , Pangihutan Simanungkalit Sabar 
Published: May 2018

Pyrolysis is one of thermochemical conversion to convert biomass into bio-oil. The higher energy content in bio-oil suggests its potential as a raw material in the production of energy, bio-fuels, and other chemicals. Pyrolysis of PKS and the chemicals released were studied using pyrolysis–gas chromatography/mass spectrometry (Py-GC/MS) at 400-600°C. Prior to pyrolysis, thermogravimetry experiments were carried out to monitor the degradation temperature of hemicellulose, cellulose, and lignin in the PKS. Degradation of hemicellulose occurred within a temperature range of 150-330°C, whereas the cellulose was degraded in temperatures range between 330-400°C. Degradation of lignin took place within a broad range of temperatures, which reached maximum at temperatures range of 200-500°C. Based on the Py-GC/MS results, pyrolysis of PKS at 400°C produced bio-oil that can be used as biofuel due to its high aromatic compounds but low carboxylic acids contents. Keywords: bio-oil; chemical; palm kernel shell; Py-GC/MS; thermogravimetry .