bluuebunny/crossref_metadata_2025_split huggingface dataset:
Consumer self-protection behavior of online meal safety during the COVID-19 pandemic: the impact of risk perception and effect of satisfaction with management safety performance
Authors: Liu Weijun , Cao Mengzhen , Florkowski Wojciech J. 
Published: November 2024

PurposeThis study aims to assess the effects of risk perception and management subject satisfaction on consumers' online meal food safety self-protection behavior during the COVID-19 pandemic.Design/methodology/approachThis study uses 742 questionnaires collected via a two-stage online survey conducted during the COVID-19 pandemic, between December 2021 and January 2022. The entropy method, descriptive statistics, ordered logit model, stepwise regression models, interaction terms and decentralization method were used in the quantitative analysis. Respondents’ written responses to self-protection behavior were categorized into five groups.FindingsLess than half of consumers were aware that online food products carry the risk of SARS-COV-2 (44.48%). Between 30 and 40% of consumers took insufficient or no self-protection measures. Risk perception significantly and positively affected self-protection behavior during the COVID-19 pandemic. Consumers' management subject satisfaction has a positive moderating effect on risk perception, with the moderating effect of the satisfaction of online retailers being significant at the 5% level. Risk perception significantly and positively influences consumer self-protection behavior in provinces not affected by the pandemic.Originality/valueThe findings stress the benefits of synergistic interventions by consumers and management subject to food safety measures and the inclusion of tailored interventions during events threatening public health to effectively address food safety. The study offers valuable insights contributing to the improvement of public health outcomes, customer trust and service quality within the online food delivery industry.
Christians and the Parable of the Vineyard Workers: Christianity, distributive justice perception, and job satisfaction
Authors: Yoon Yeongjoon , Almond Brad 
Published: November 2024

PurposeDespite recent efforts to link religion with job satisfaction, the current state of research lacks the knowledge of why there may be a positive relationship between the two variables. This study tries to fill this gap by testing the notion that Christians are more likely to exhibit a higher level of distributive justice perception, which leads to a higher level of job satisfaction. The study also tries to identify Christianity as the moderator in the relationship between distributive justice and job satisfaction.Design/methodology/approachThis study uses secondary data. The study analyzes 13,289 employees in 27 countries in the 2010 European Social Survey, which contains information on the levels of distributive justice perceptions and job satisfaction, as well as the religious affiliations of the respondents. The country fixed effect regression analysis was conducted.FindingsThe analyses first reveal that Protestants, compared to non-Protestants, exhibit a higher level of distributive justice perception, which leads to a higher level of job satisfaction. The analyses also demonstrate that the positive relationship between distributive justice perception and job satisfaction is weaker for Protestants than non-Protestants. These relationships, however, were not evident for people affiliated with other denominations of Christianity.Practical implicationsProtestant employees are likely to maintain a higher level of distributive justice perception, and distributive justice perception matters less in shaping their job satisfaction. As a result, organizations may want to focus more on the other aspects of organizational justice, such as procedural and interactional justices in managing protestant employees, if maintaining job satisfaction level is a concern. With many “Christian-based” companies operating and being supported in today’s economy, the findings in this study can be useful to these organizations that are more likely to attract and have Christians as their employees.Originality/valueThe current study provides evidence that employees’ religious affiliation (i.e. Protestantism in this case) can be a predictor of job satisfaction through the mediation of distributive justice perception. It also offers a basis for future studies on employee morale (e.g. job satisfaction and justice perceptions) to consider religious factors. Finally, the findings also identify Protestant affiliation as a moderator in the distributive justice–job satisfaction relationship.
Finding grace in responses to adverse cybersecurity incidents
Authors: Dupuis Marc , Searle Rosalind , Renaud Karen V. 
Published: November 2024

PurposeThe purpose of this study was to investigate the role of grace in the aftermaths of adverse cybersecurity incidents. Adverse incidents are an inescapable fact of life in organizational settings; consequences could be significant and costly. Increasingly, the cause may be a cybersecurity exploit, such as a well-targeted phishing email. In the aftermath, line managers have a choice in responding to the individual who caused the incident. Negative emotions, such as shame and regret, may deliberately be weaponized. Alternatively, positive emotions, such as grace, forgiveness and mercy, may come into play.Design/methodology/approachWe detail a study with 60 participants to explore attribution differences in response to adverse incidents, both non-cybersecurity and cybersecurity. We examined the stages that occur in the aftermath of such adverse incidents where grace may be observed.FindingsOur participants generally believed that grace was indicated toward those who triggered an adverse cybersecurity incident, pointing to situational causes. This was in stark contrast to their responses to the non-cybersecurity incident, where the individual was often blamed, with punishment being advocated.Research limitations/implicationsThe role of positive emotions merits investigation in the cybersecurity context if we are to understand how best to manage the aftermaths of adverse cybersecurity incidents.Practical implicationsOrganizations that mismanage aftermaths of adverse incidents by blaming, shaming and punishing those who make mistakes will harm the individual who made the mistake, other employees and the long-term health of their organization in the long run.Originality/valueTo the best of the authors’ knowledge, this is the first study to reveal the grace phenomenon in the cybersecurity context.
Latino adolescents’ experiences of residential risks on social media and mental health implications
Authors: Campos‐Castillo Celeste , Groh Sarah M. , Laestadius Linnea I. 
Published: November 2024

AbstractDespite alarms raised that adolescents’ social media use can aggravate the harmful impact of residential risks (e.g. local violence) to their mental health, the mechanisms are poorly understood. To better understand potential mechanisms, we interviewed Latino adolescents living in a hypersegregated U.S. city, for whom social media may aggravate existing inequalities in residential risks to their mental health. Through an abductive analysis, we identified two processes suggesting how social media can amplify the deleterious impact of residential risks to their mental health. We refer to the first as additive, whereby social media heightens awareness of residential risks. The second is extension, whereby social media lengthens one’s risk awareness, speeds up potential for risk awareness and multiplies who may become aware. We found evidence suggestive of parallel processes yielding diminution, whereby social media can minimise the deleterious effects of residential risks via adding and extending exposure to mental health resources, like collective efficacy. Further, the potential for extension (to both risks and resources) appears limited because social media practices (e.g. reposting, seeking viral attention) can foster indifference. Findings suggest the need to consider how adolescents activate resources via social media to avoid overstating its negative impact on mental health.
Harnessing Gram‐negative bacteria for novel anti‐Gram‐negative antibiotics
Authors: Birkelbach Joy , Seyfert Carsten E. , Walesch Sebastian , Müller Rolf 
Published: November 2024

AbstractNatural products have proven themselves as a valuable resource for antibiotics. However, in view of increasing antimicrobial resistance, there is an urgent need for new, structurally diverse agents that have the potential to overcome resistance and treat Gram‐negative pathogens in particular. Historically, the search for new antibiotics was strongly focussed on the very successful Actinobacteria. On the other hand, other producer strains have been under‐sampled and their potential for the production of bioactive natural products has been underestimated. In this mini‐review, we highlight prominent examples of novel anti‐Gram negative natural products produced by Gram‐negative bacteria that are currently in lead optimisation or preclinical development. Furthermore, we will provide insights into the considerations and strategies behind the discovery of these agents and their putative applications.
TMEM16F regulates pathologic α‐synuclein secretion and spread in cellular and mouse models of Parkinson's disease
Authors: Cohen‐Adiv Stav , Amer‐Sarsour Fatima , Berdichevsky Yevgeny , Boxer Emily , Goldstein Orly , Gana‐Weisz Mali , Tripathi Utkarsh , Rike Wote Amelo , Prag Gali , Gurevich Tanya , Giladi Nir , Stern Shani , Orr‐Urtreger Avi , Friedmann‐Morvinski Dinorah , Ashkenazi Avraham 
Published: November 2024

AbstractOne of the main hallmarks of Parkinson's disease (PD) pathology is the spread of the aggregate‐prone protein α‐synuclein (α‐syn), which can be detected in the plasma and cerebrospinal fluid of patients as well as in the extracellular environment of neuronal cells. The secreted α‐syn can exhibit “prion‐like” behavior and transmission to naïve cells can promote conformational changes and pathology. The precise role of plasma membrane proteins in the pathologic process of α‐syn is yet to be fully resolved. The TMEM16 family of lipid scramblases and ion channels has been recently associated with cancer and infectious diseases but is less known for its role in aging‐related diseases. To elucidate the role of TMEM16F in α‐syn spread, we transduced neurons derived from TMEM16F knockout mice with a reporter system that enables the distinction between donor and recipient neurons of pathologic α‐synA53T. We found that the spread of α‐synA53T was reduced in neurons derived from TMEM16F‐knockout mice. These findings were recapitulated in vivo in a mouse model of PD, where attenuated α‐synA53T spread was observed when TMEM16F was ablated. Moreover, we identified a single nucleotide polymorphism in TMEM16F of Ashkenazi Jewish PD patients resulting in a missense Ala703Ser mutation with enhanced lipid scramblase activity. This mutation is associated with altered regulation of α‐synA53T extracellular secretion in cellular models of PD. Our study highlights TMEM16F as a novel regulator of α‐syn spread and as a potential therapeutic target in synucleinopathies.
Safety and efficacy of surgical revascularization with percutaneous ventricular assist device for acute myocardial infarction complicated by cardiogenic shock: Japanese national registry study
Authors: Fujii Masahiko , Okino Shinichi , Sakata Tomoki , Mogi Kenji , Sakurai Manabu , Takahara Yoshiharu ,   J‐PVAD Registry Investigators
Published: November 2024

AbstractBackgroundThis study aims to assess the safety of coronary artery bypass grafting (CABG) with percutaneous ventricular assist device (PVAD) in patients with acute myocardial infarction complicated by cardiogenic shock (AMI‐CS).MethodsA retrospective analysis was conducted on 1198 patients with AMI‐CS from the J‐PVAD registry, who underwent PVAD support using Impella® (Abiomed Inc., Danvers, MA) and subsequent revascularization between February 2020 and December 2021. Patients were divided into two groups based on the method of coronary revascularization: percutaneous coronary intervention (PCI, n = 1084) and CABG (n = 114). The study assessed short‐term all‐cause and cardiac‐related mortality.Results and conclusionThe CABG group exhibited significantly lower short‐term all‐cause mortality compared with the PCI group (30‐day: 26.2% vs. 39.9%, 90‐day: 45.5% vs. 58.4%, log‐rank p = 0.004). Short‐term cardiac‐related mortality was similar toward low in the CABG group compared with the PCI group (30‐day: 18.7% vs. 25.6%, 90‐day: 29.4% vs. 35.5%, log‐rank p = 0.084). Multivariable analysis using the Cox proportional hazard model did not identify revascularization strategy as a risk factor for both all‐cause mortality (Hazard ratio (HR): 0.743, 95% confidence intervals (CI): 0.457–1.208, p = 0.231) and cardiac‐related mortality (HR: 0.762, 95% CI: 0.390–1.490, p = 0.427). These results were not attenuated even in subgroup analyses separately comparing CABG alone and hybrid therapy with PCI after propensity score matching. Thus, CABG can be a treatment option with feasible short‐term outcomes in patients with AMI‐CS under PVAD support.
Higher initial levothyroxine doses and very early treatment start may lead to better cognitive outcomes in children with congenital hypothyroidism
Authors: Danner Emmi , Niuro Laura , Lapinoja Sonja , Huopio Hanna , Viikari Liisa A. , Kero Jukka , Jääskeläinen Jarmo , Niinikoski Harri 
Published: November 2024

AbstractAimThis study aimed to assess the cognitive development of individuals with congenital hypothyroidism.MethodsUsing hospital records, we identified 180 patients with congenital hypothyroidism born between 1980 and 2018 in Turku and Kuopio University Hospital catchment areas. Cognitive development was evaluated in 22 adults (7 males and 15 females) and 20 children (8 males and 12 females) using age‐specific Wechsler Intelligence Scales. Full‐scale IQ (FSIQ) and the four indices were compared to standardisation samples. Simple linear regression was used to test whether treatment‐related variables predicted FSIQ.ResultsFSIQ and its four indices differed significantly from the standardisation sample in adults with congenital hypothyroidism (FSIQ 87.64, SD 13.70, p < 0.001) but not in children (FSIQ 97.90, SD 15.12). Adults had received a lower initial levothyroxine dose than children (8.1 mg/kg, 95% CI 7.2–9.0 vs. 10.2 mg/kg 9.7–10.7, p < 0.001), and their treatment was initiated later (4.8 days, 95% CI 4.0–5.6 vs. 3.6 days, 2.9–4.2, p = 0.018).ConclusionAdults with congenital hypothyroidism had a significantly lower FSIQ compared to the population standard, while children's FSIQ did not differ. Our findings suggest that a higher initial levothyroxine dose together with very early treatment start may lead to better cognitive outcomes.
Epidemiology of paediatric winter sports‐related injuries in France: The WINTRAUMA‐1 retrospective cohort study
Authors: Mugniery Quentin , Ricard Cécile , Mirtain Suzanne , Navarre Manon , Tanné Corentin 
Published: November 2024

AbstractAimTo describe the epidemiology of injuries related to winter sports in patients younger than 15 years in France.MethodsWe conducted a retrospective observational multicentre cohort study of patients younger than 15 years who were seen by mountain‐community general practitioners for winter‐sports injuries in 1999–2022.ResultsOf the 108 619 patients (mean age, 11.4 ± 2.8 years), 76 724 (70.6%), 26 186 (24.1%) and 2132 (2.0%) were injured while skiing, snowboarding and sledding, respectively. Helmet use was noted in 50 164 (46.2%) patients and increased over time but remained low among sledders. A collision was the mechanism in 12.3% of patients overall and 32.1% of sledders. The most common injuries overall were wrist fractures (48.5%), head and trunk injuries (42.3%), and anterior cruciate ligament (ACL) tears (23.7%), with wrist fractures being more common in beginners (24.7%) and head/trunk injuries and ACL tears in advanced participants (18.3% and 2.6%, respectively). Only 3699 (3.4%) patients were admitted after the general‐practitioner visit, notably for leg or ankle fractures (9.5%).ConclusionWinter sports‐related injuries vary according to age, sex, skill level and sport. Admission rates are low but might be further decreased by better prevention. Protective measures should be tailored to each sport and individual.
Working group summary of the 2023 full update of the Finnish national guidelines for paediatric lower respiratory tract infections
Authors: Backman Katri , Helminen Merja , Kekäläinen Eliisa , Mikkola Ilona , Nieminen Tea , Nuolivirta Kirsi , Peltola Ville , Seuri Raija , Walle Satu‐Maaria , Ruuska‐Loewald Terhi 
Published: November 2024

AbstractAimThe first evidence‐based Finnish guidelines for paediatric lower respiratory tract infections (LRTIs) were published in 2014 and completely updated in 2023. This paper, by the interdisciplinary working group that developed the 2023 guidelines, summarises the main recommendations.MethodsThe 2023 guidelines were produced after a systematic review. Strong evidence was at least two separate, high‐quality studies, moderate evidence was at least one high‐quality study and weak evidence was at least one satisfactory study. The authors have now summarised the key points.ResultsThere was strong evidence that antitussives and beta‐sympathomimetics were not effective for bronchitis‐related cough and that laryngitis should be treated with oral corticosteroids, with adrenaline inhalations added in severe cases. Also, that amoxicillin for 5 days provided sufficient treatment for paediatric community‐acquired pneumonia and that children with apparent viral pneumonia could be observed without antimicrobial therapy. There was moderate evidence that corticosteroids or inhaled agents were not effective for bronchiolitis and that administering salbutamol with a holding chamber could relieve symptoms of wheezing bronchitis. Also, pertussis should be considered for unvaccinated infants with coughs.ConclusionThe 2023 guidelines aim to improve acute evidence‐based treatment of LRTIs, through appropriate antibiotics, inhaled drugs, corticosteroids, radiology and laboratory testing.
Recent advances in noncoding RNA modifications of gastrointestinal cancer
Authors: Hara Tomoaki , Meng Sikun , Arao Yasuko , Saito Yoshiko , Inoue Kana , Rennie Sarah , Ofusa Ken , Doki Yuichiro , Eguchi Hidetoshi , Kitagawa Toru , Ishii Hideshi 
Published: November 2024

AbstractElucidating the mechanisms underlying cancer development and proliferation is important for the development of therapeutic methods for the complete cure of cancer. In particular, the identification of diagnostic markers for early detection and new therapeutic strategies for refractory gastrointestinal cancers are needed. Various abnormal phenomena occur in cancer cells, such as functional changes of proteins, led by genomic mutations, and changes in gene expression due to dysregulation of epigenetic regulation. This is no exception for noncoding RNA (ncRNA), which do not encode proteins. Recent reports have revealed that microRNA (miRNA), long noncoding RNA (lncRNA), and circular RNA (circRNA) are deeply involved in cancer progression. These ncRNAs have attracted attention as gene expression regulatory molecules. Recent advances in technology have made it possible not only to read DNA and RNA sequences but also to study the modification state of each base. In particular, comprehensive analysis of N6‐methyladenosine (m6A) has been performed by many research groups, with multiple studies reporting that m6A modifications of specific genes are associated with cancer progression. Based on the above, this review examines how ncRNA modifications are related to cancer progression in gastrointestinal cancers such as colorectal and pancreatic cancer. We also discuss enzyme inhibitors that have been reported to have drug discovery potential targeting m6A modifications. By utilizing the new perspective of ncRNA modification, we may be able to accumulate knowledge on the molecular biology of cancer and contribute to human health through diagnosis and treatment.
Adiponectin as a biomarker in liver cirrhosis—A systematic review and meta‐analysis
Authors: Ismaiel Abdulrahman , Ciornolutchii Vera , Herrera Thelva Esposito , Ismaiel Mohamed , Leucuta Daniel‐Corneliu , Popa Stefan‐Lucian , Dumitrascu Dan L. 
Published: November 2024

AbstractIntroductionAdiponectin, a key adipokine, shows promise as a non‐invasive biomarker for liver cirrhosis by reflecting inflammation and metabolic changes, but conflicting findings highlight the need for a systematic review and meta‐analysis to clarify its role. Our study aimed to evaluate adiponectin levels across various stages of liver cirrhosis, compare them with other chronic liver diseases (CLD) and hepatocellular carcinoma (HCC), and assess its potential as a diagnostic and prognostic biomarker.MethodsOur systematic search was conducted on September 2023 using PubMed, EMBASE and Scopus, searching for observational studies evaluating serum and plasma adiponectin levels in liver cirrhosis. Inclusion and exclusion criteria were applied, and study quality was assessed using the Newcastle‐Ottawa Scale. To evaluate the overall effect size, we utilized a random‐effects model along with a mean difference (MD) analysis. The principal summary outcome was the MD in adiponectin levels.ResultsWe included 16 articles involving 2617 subjects in our qualitative and quantitative synthesis. We found significantly higher adiponectin levels in liver cirrhosis patients (8.181 [95% CI 3.676, 12.686]), especially in Child‐Pugh B individuals (13.294 [95% CI 4.955, 21.634]), compared to controls. Child‐Pugh A patients did not show significant differences compared to controls. In addition, adiponectin levels were significantly elevated in primary biliary cholangitis (PBC) patients compared to controls (8.669 [95% CI .291, 17.047]), as well as in liver cirrhosis compared to other CLD patients (4.805 [95% CI 1.247, 8.363]), including non‐alcoholic fatty liver disease (NAFLD) (8.532 [95% CI 3.422, 13.641]), but not viral hepatitis. No significant MD was observed between liver cirrhosis and HCC patients.ConclusionAdiponectin levels are significantly elevated in liver cirrhosis, especially in advanced stages, potentially serving as a biomarker for advanced cirrhosis. Adiponectin also differentiates cirrhosis from other CLD, including NAFLD. However, its role in distinguishing cirrhosis from viral hepatitis and HCC is limited.