bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dimensiones ético-políticas del concepto "pathos de la distancia" en la filosofía de Nietzsche
Authors: García-Granero Marina 
Published: July 2019

En el presente artículo me propongo elucidar el significado del concepto “pathos de la distancia” y sus implicaciones ético-políticas, destacando su sentido y coherencia con el conjunto del pensamiento nietzscheano. La tesis fundamental es que el pathos de la distancia, como característica básica del ideal noble, muestra cómo el concepto de supremacía política en Nietzsche se disuelve siempre en una idea de preeminencia anímica. La reflexión se enmarca dentro de la crítica nietzscheana de la cultura, la política y la educación, y su propuesta de reforma de los valores dominantes de la sociedad, entre ellos, los que configuran la subjetividad y la individualidad. Se estudian las diversas dimensiones del pathos de la distancia: como articulación jerárquica, como principio de individualidad, como parte la Gran Política y como elemento del pensamiento de la cría (Züchtung) de la humanidad.Palabras clave: pathos de la distancia, valor, moral, gran política, cría.
Preoperative Diagnosis of Upper Gastrointestinal Leiomyoma by Endoscopic Ultrasound-guided Fine Needle Aspiration
Authors: Shaprynskyi V. O. , Nasr Zaki Nageeb , Babii Y. V. , Alkamali Abdulhakeem 
Published: July 2019

Aims: To evaluate the role of endoscopic ultrasonography-guided fine needle aspiration (EUS-FNA) with using immunohistochemical analysis in the preoperative diagnosis of upper gastrointestinal leiomyoma.
Study Design: This was ’prospective’ observational study.
Place and Duration of Study: Department of surgery №1, Vinnytsia National Pirogov Medical University, Vinnytsia, Ukraine; between September 2016 and February 2019.
Methodology: Sixteen prospectively studies have been performed using endoscopic ultrasonography-guided fine needle aspiration (EUS-FNA) in patients with submucosal hypoechoic tumors (according to the results of previous gastroduodenoscopy) with continuity to proper muscle layer suspected as leiomyoma of upper gastrointestinal tract. All cases for the final diagnosis underwent surgery (n = 16). Additionally, immunophenotyping of specimens obtained by EUS-FNA and surgical resection specimens have been compared.
Results: The puncture has been performed in all patients without any anatomical problems. The collection rate of adequate specimens from the GI tract subepithelial hypoechoic tumor with continuity to proper muscle layer was 87, 5%. The diagnostic rate for the tumor less than 2 cm, 2 to 4 cm, and 4 cm or more were 77, 8%, 100% and 100% respectively. In 16 surgically resected cases, the sensitivity, specificity, positive predictive value, negative predictive value, and diagnostic accuracy of EUS-FNA using immunohistochemical analysis of leiomyoma were 100%; 83,3%; 90,9%; 100% and 93,75% respectively. No major complications were encountered.
Conclusion: EUS-FNA with immunohistochemical analysis is a safe and accurate method in the preoperative diagnosis of gastrointestinal leiomyoma. It should be taken into consideration in decision making, especially in early diagnosis following minimal invasive surgery for gastrointestinal leiomyoma.
Avant‐Garde in the Age of Identity: Alvin Boyarsky, the Architectural Association and the Impact of Pedagogy
Authors: Marjanovic Igor 
Published: July 2019

AbstractUnder the stewardship of its iconic chairman Alvin Boyarsky, the Architectural Association (AA) presided over a burgeoning of architectural avant‐garde tendencies that encouraged tutors and students to expand their architectural vocabulary and outlook by embracing issues of sexuality and identity, as well as other art forms. St Louis‐based architect, historian and academic Igor Marjanovic explores this era.
Logic‐Based Delivery of Site‐Specifically Modified Proteins from Environmentally Responsive Hydrogel Biomaterials
Authors: Gawade Prathamesh Milind , Shadish Jared A. , Badeau Barry A. , DeForest Cole A. 
Published: July 2019

AbstractThe controlled presentation of proteins from and within materials remains of significant interest for many bioengineering applications. Though “smart” platforms offer control over protein release in response to a single external cue, no strategy has been developed to trigger delivery in response to user‐specified combinations of environmental inputs, nor to independently control the release of multiple species from a homogenous material. Here, a modular semisynthetic scheme is introduced to govern the release of site‐specifically modified proteins from hydrogels following Boolean logic. A sortase‐mediated transpeptidation reaction is used to generate recombinant proteins C‐terminally tethered to gels through environmentally sensitive degradable linkers. By varying the connectivity of multiple stimuli‐labile moieties within these customizable linkers, YES/OR/AND control of protein release is exhaustively demonstrated in response to one and two‐input combinations involving enzyme, reductant, and light. Tethering of multiple proteins each through a different stimuli‐sensitive linker permits their independent and sequential release from a common material. It is expected that these methodologies will enable new opportunities in tissue engineering and therapeutic delivery.
Additional Organic‐Solvent‐Rinsing Process to Enhance Perovskite Photovoltaic Performance
Authors: Song Qi , Liang Chunjun , Zhang Huimin , Ji Chao , Sun Mengjie , Sun Fulin , Jing Xiping , You Fangtian , Lu Yanwu , He Zhiqun 
Published: July 2019

AbstractMethylammonium lead iodide (MAPbI3) perovskite is manipulated through an additional organic‐solvent‐rinsing process during an intermediate film fabrication stage. This additional process includes low‐temperature preannealing following by rinsing the films using isobutyl alcohol (IBA) before final annealing. This partially dissolves the small crystals in the perovskite intermediate and reduces nucleation density. The small crystals recrystallize into larger sizes via a dissolution–crystallization mechanism, leading to a reduction in the grain boundaries and interfacial defects. Preannealing is also crucial in solubility control and for tuning the crystallization. Crystal‐size‐dependent optical band gaps may be attributed to a weak quantum confinement effect. Excess PbI2 residue is induced at the perovskite surface thanks to the selective solubility of IBA, which improves the passivation of the perovskite surface. A synergistic improvement in grain size and in PbI2 residue leads to substantial enhancement in device performance. The power conversion efficiency of an optimized photovoltaic device reaches 18.47%, which is more than a 15% increase compared to a control device.
A 3D Trilayered CNT/MoSe2/C Heterostructure with an Expanded MoSe2 Interlayer Spacing for an Efficient Sodium Storage
Authors: Yousaf Muhammad , Wang Yunsong , Chen Yijun , Wang Zhipeng , Firdous Attia , Ali Zeeshan , Mahmood Nasir , Zou Ruqiang , Guo Shaojun , Han Ray P. S. 
Published: July 2019

AbstractFreestanding composite structures with embedded transition metal dichalcogenides (TMDCs) as the active material are highly attractive in the development of advanced electrodes for energy storage devices. Most 3D electrodes consist of a bilayer design involving a core–shell combination. To further enhance the gravimetric and areal capacities, a 3D trilayer design is proposed that has MoSe2 as the TMDC sandwiched in‐between an inner carbon nanotube (CNT) core and an outer carbon layer to form a CNT/MoSe2/C framework. The CNT core creates interconnected pathways for the e−/Na+ conduction, while the conductive inert carbon layer not only protects the corrosive environment between the electrolyte and MoSe2 but also is fully tunable for an optimized Na+ storage. This unique heterostructure is synthesized via a solvothermal‐carbonization approach. Due to annealing under a confined structural configuration, MoSe2 interlayer spaces are expanded to facilitate a faster Na+ diffusion. It is shown that an ≈3 nm thick carbon layer yielded an optimized anode for a sodium‐ion battery. The 3D porosity of the heterostructure remains intact after an intense densification process to produce a high areal capacity of 4.0 mAh cm−2 and a high mass loading of 13.9 mg cm−2 with a gravimetric capacity of 347 mAh g−1 at 500 mA g−1 after 500 cycles.
MCMC calibration of spot‐prices models in electricity markets
Authors: Guerini Alice , Marziali Andrea , De Nicolao Giuseppe 
Published: July 2019

AbstractThe calibration of some stochastic differential equation used to model spot prices in electricity markets is investigated. As an alternative to relying on standard likelihood maximization, the adoption of a fully Bayesian paradigm is explored, that relies on Markov chain Monte Carlo (MCMC) stochastic simulation and provides the posterior distributions of the model parameters. The proposed method is applied to one‐ and two‐factor stochastic models, using both simulated and real data. The results demonstrate good agreement between the maximum likelihood and MCMC point estimates. The latter approach, however, provides a more complete characterization of the model uncertainty, an information that can be exploited to obtain a more realistic assessment of the forecasting error. In order to further validate the MCMC approach, the posterior distribution of the Italian electricity price volatility is explored for different maturities and compared with the corresponding maximum likelihood estimates.
Dramatic red fluorescence enhancement and emission red shift of carbon dots following Zn/ZnO decoration
Authors: Zuo Gancheng , Hu Jiangsheng , Wang Yuting , Xie Aming , Dong Wei 
Published: July 2019

AbstractMetal atom doping, an easy and convenient method, can optimize and tune the physical–chemical properties and photometrics of carbon dots (CDs). However, there are few reports on the preparation of metal‐decorated CDs that give red emission and a high photoluminescence quantum yield (PLQY). Here, we demonstrate a zinc (existing in human body) ion‐doping strategy to observably enhance the PLQY and lengthen the CD emission wavelength. The prepared Zn/ZnO‐decorated CDs (Zn‐CDs) produced red fluorescence (623 nm) with a superior PLQY of 40.3%. Through a series of analyses, Zn‐CDs were confirmed to contain an oxidation state and reduction state of Zn doping into the internal defects and surface of Zn‐CDs. More valuably, the Zn‐CDs had excellent chemical stability, photo‐stability, long‐term storage stability, and high biocompatibility, and therefore could be used as a robust red fluorescence probe for high‐quality cellular imaging.
Development and validation of a generic RP‐HPLC PDA method for the simultaneous separation and quantification of active ingredients in cold and cough medicines
Authors: Dongala Thirupathi , Katari Naresh Kumar , Palakurthi Ashok Kumar , Jonnalagadda Sreekantha B. 
Published: July 2019

AbstractA novel generic reverse phase high performance liquid chromatography (RP‐HPLC) method is developed and validated for simultaneous determination of seven pharmaceutically active ingredients, namely, acetaminophen, dextromethorphan, doxylamine, phenylephrine, guaifenesin, caffeine and aspirin. All seven ingredients were quantified in soft gel, syrup and tablet formulations of the over‐the‐counter US‐marketed products, as per the guidelines of the International Conference on Harmonization. The separation was achieved in a 16 min run time on an Agilent Zorbax Phenyl column using a gradient method with two mobile phases. Mobile phase A was 0.15% trifluoro acetic acid in purified water and while mobile phase B was a mixture of acetonitrile and methanol (750:250 v/v) with 0.02% trifluoro acetic acid. The flow rate was 1.0 mL min−1 and injection volume was 10 μL. Detection was performed at 280 nm using a photodiode array detector. As part of the method validation, specificity, linearity, precision and recovery parameters were verified. The concentration and area relationships were linear (R2 > 0.999), over the concentration ranges 20–120 μg mL−1 for acetaminophen, 75–450 μg mL−1 for dextromethorphan, 31.25–187.5 μg mL−1 for doxylamine, 25–150 μg mL−1 for phenylephrine, 25–150 μg mL−1 for aspirin, 6.5–39 μg mL−1 for caffeine and 12–72 μg mL−1 for guaifenesin. The relative standard deviations for precision and intermediate precision were <1.5%. The proposed RP‐HPLC generic method is applicable for routine analysis of cold and cough over‐the‐counter products.
Low cost DSP‐based educational embedded platform for real‐time simulation and fast implementation of complex systems in Simulink
Authors: Dávila Delgado Emmanuel , Raygoza Panduro Juan José , Becerra Álvarez Edwin Christian , Espinoza Jurado Francisco Javier , Gutiérrez Frías Eric Francisco 
Published: July 2019

AbstractIn this paper, we present a teaching methodology based on a low‐cost embedded system platform that is easy to use and replicate, oriented to real‐time simulation project development. Designed for real‐time implementation of coding generated with MPLAB Device Blocks for Simulink. The purpose of this methodology is that students, teachers, and professionals will be able to carry out a theoretical project of a simulation in a computer, which includes complex mathematical modeling, to interact with its environment in real‐time. This system has been utilized already by students of Engineering of the first semesters as well as professors and researchers in updated and initialization courses in embedded systems within the University of Guadalajara. Finally, in the results section, we show a comparison of the proposed platform and a dSPACE platform applied in a control problem with an intricate mathematical model to process through a Hardware‐in‐the‐loop (HIL).
Distribution of hospital care among pediatric and young adult Hodgkin lymphoma survivors—A population‐based cohort study from Sweden and Denmark
Authors: Glimelius Ingrid , Englund Annika , Rostgaard Klaus , Smedby Karin E. , Eloranta Sandra , de Nully Brown Peter , Johansen Christoffer , Kamper Peter , Ljungman Gustaf , Hjalgrim Lisa Lyngsie , Hjalgrim Henrik 
Published: July 2019

AbstractThe burden of late effects among Hodgkin lymphoma (HL) survivors treated according to contemporary protocols remains poorly characterized. We used nation‐wide registers to assess number of inpatient bed‐days and specialist outpatient visits among 1048 HL‐patients (<25 years, diagnosed 1990‐2010) and 5175 country‐, sex‐, and age‐matched comparators. We followed them for up to 24 years, with time‐dependent assessment of relapse status. International Classification of Diseases (ICD‐10) chapter‐specific hazard ratios (HRs) were assessed in Cox regression analyses, and nonparametric statistics described patterns of health‐care‐use. Relative to comparators, relapse‐free survivors were at increased risk of infections, diseases of the blood, endocrine, circulatory and respiratory systems, and unspecific symptoms, HRs ranging from 1.86 to 3.05. Relative to comparators, relapsed survivors had at statistically significantly increased risk of diseases reflecting practically all investigated disease‐chapters, HRs ranging from 1.60 to 18.7. Among relapse‐free survivors, 10% of the patients accounted for 80% of all hospital bed days, and 55% were never hospitalized during follow‐up. Among relapsed‐survivors, 10% of the patients accounted for 50% of the bed days, and only 24% were never hospitalized during follow‐up. In contrast, 10% of the comparators accounted for 90% of hospital bed days and 75% were never hospitalized. These findings challenge the impression of a uniformly distributed long‐term morbidity among all HL survivors and emphasize the need for early identification and attention to patients particularly susceptible to late effects, such as relapsed survivors.
Gene polymorphism of cytochrome P450 significantly affects lung cancer susceptibility
Authors: Li Meng , Li Anqi , He Ruiqing , Dang Wenhui , Liu Xinyu , Yang Tian , Shi Puyu , Bu Xiang , Gao Dan , Zhang Ning , Du Shuli , Jin Tianbo , Chen Mingwei 
Published: July 2019

AbstractBackgroundCytochrome P450 (CYPs) are heme proteins involved in the metabolism of a variety of endogenous and exogenous substances and play an important role in the carcinogenesis mechanisms of environmental and hereditary factors. The objective of this study was to investigate how polymorphisms of CYPs correlate with lung cancer (LC) susceptibility.MethodsSix single nucleotide polymorphisms (SNPs) were genotyped in this study. The chi‐square test and unconditional logistic regression model were used to evaluate the correlation between SNPs and LC susceptibility. The expressions and survival data of genes in patients with LC were mined using Oncomine and Kaplan‐Meier Plotter database.ResultsFour SNPs were found to be significantly associated with the risk of LC development (P < 0.05). The most significant correlation was that the A allele and AA genotype of CYP2D6 rs1065852 were associated with increased risk of LC development (adjusted odds ratio [OR] = 1.35, 95% confidence interval [95%CI] = 1.13‐1.60, P = 9.04e‐4; OR = 1.83, 95%CI = 1.29‐2.59, P = 0.001 respectively). Similar association of this variant was also found in the subgroups of male patients, cases in III‐IV stages, positive lymph node, squamous cell carcinomas and adenocarcinomas. Whereas rs1065852 was considered as protective factor in females (adjusted OR = 0.33, 95% CI = 0.16‐0.70, P = 0.004). In stratified analyses, the association of CYP24A1 rs2762934, CYP24A1 rs6068816, CYP20A1 rs2043449 polymorphism with LC risk appeared stronger in some subgroups. CYP2D6, CYP24A1 and CYP20A1 are overexpressed in some pathological types of LC (P < 0.05), and high levels of CYP2D6 and CYP20A1 indicate poor and good prognosis of LC, respectively.ConclusionThis study revealed that rs1065852, rs2043449, rs2762s934, and rs6068816 of CYPs were associated with LC susceptibility in the Northwestern Chinese Han population; CYP2D6 and CYP20A1 were overexpressed and correlated with prognosis of LC.
Evaluating the Graded Care Profile 2: Comparisons with the Original Tool and Factors Affecting Uptake and Use of the Updated Tool
Authors: Smith Emma , Johnson Robyn , Andersson Tove , Belton Emma , Kyriacou Samantha , Hodson Dawn 
Published: July 2019

Previous research on the original Graded Care Profile, widely used in assessments of child neglect, found that it helped practitioners make more objective, evidence‐based decisions where neglect was suspected. However, the tool was also criticised for being too long and not very user‐friendly. Subsequently, the tool was revised, updated and renamed the ‘Graded Care Profile 2’ (GCP2). The NSPCC supported the implementation of this tool in 65 local authorities.This article reports on an evaluation of the GCP2 conducted by the NSPCC, involving surveys and interviews with a range of participants trained to use the tool or involved in its implementation. The evaluation aimed to identify barriers and facilitators to using the tool, and to observe whether changes made to the original tool had helped.‘This article reports on an evaluation of the GCP2 conducted by the NSPCC’Participants were positive about the GCP2, which some interviewees said was a huge improvement on the original tool. They felt that it increased their confidence to identify neglect and make referrals which were more likely to have an impact, because interviewees felt that it produced clear evidence which held weight within the child protection field. There were reservations about aspects of the tool and, although the roll‐out appeared successful overall, use of the tool was fairly limited eight to ten months following training.Key Practitioner Messages

The GCP2 was viewed as more accessible, attractive and user‐friendly than the original tool. There were some concerns about aspects of the tool, such as its length.
Practitioners who used the tool felt that it improved their confidence to identify neglect and helped them make referrals which were more likely to have an impact.
The majority of local authorities initially involved in rolling out the GCP2 were still engaged and using the GCP2.
Rhabdomyosarcoma debut masquerading as acute lymphoblastic leukemia: A case report and review of the literature
Authors: López‐Andrade Bernardo , Duran Maria Antonia , Torres Lourdes , García‐Recio Marta , Lo Riso Laura , Formica Alejandro , Ramos Rafael F. , Cerda Niurka , Sampol Antonia 
Published: July 2019

AbstractBone marrow infiltration by alveolar rhabdomyosarcoma is uncommon, some cases can mimicry acute leukemia at presentation and mislead the diagnosis. The integration of diagnostics tests and techniques in uncommon malignancies is important to suspect and reach the diagnosis and avoid delay on treatment. We report a case of alveolar rhabdomyosarcoma bone marrow infiltration associated with hemophagocytosis and cell cannibalism, mimicking acute leukemia at presentation.
Free‐Standing 3D Electrodes for Electrochemical Detection of Hydrogen Peroxide
Authors: Peng Ming , Zhao Yang , Chen Dechao , Tan Yongwen 
Published: July 2019

AbstractElectrochemical detection of hydrogen peroxide has achieved rapid development, due to the wide presence in industrial production, everyday life, bioprocess and green energy chemistry, etc. Many three‐dimensional structures have emerged as state‐of‐the‐art electrocatalysts due to their fascinating structures and electrochemical properties. This review summarizes free‐standing three‐dimensional electrocatalysts based on metal, metal oxide, carbon & silicon, and unconventional materials for detection of hydrogen peroxide with low limit of detection, wide range and fast response. The work also highlights their applications in near neutral conditions, especially their ability for single cell detection and mapping in biological environment. Further exploration into these materials together with devices design will facilitate the development of next‐generation detection technologies toward in situ and real‐time detection and contribute to wearable/portable smart detection electronics.
Decentralized monitoring for large‐scale process using copula‐correlation analysis and Bayesian inference–based multiblock principal component analysis
Authors: Tian Ying , Hu Tian , Peng Xin , Du Wenli , Yao Heng 
Published: July 2019

AbstractDue to the massive monitored samples and their features such as strong coupling and time delay in large‐scale industrial process, the decentralized monitoring methods, which divide the variables into several blocks and perform local monitoring in each subblock, have been brought up to handle the complex characteristics. However, most of the existing decentralized methods utilize the correlation degree among variables for block division, while the correlation patterns among variables are ignored. The missing of correlation pattern will influence the monitoring performance. To address this problem, the copula‐correlation analysis, which considers both the correlation degree and the correlation pattern, is adopted for block division; then the principal component analysis (PCA)–based method is used for subblock monitoring, and the Bayesian inference is introduced to achieve decision fusion of fault detection. The superiority and effectiveness of the proposed method are illustrated through comparison studies on a numerical example and the Tennessee Eastman (TE) benchmark process.