bluuebunny/crossref_metadata_2025_split huggingface dataset:
Changes in symptom pattern in Meniere's disease by duration: the need for comprehensive management
Authors: Pyykkö Ilmari , Zou Jing , Vetkas Nora 
Published: November 2024

PurposeThis retrospective study aimed to analyze the symptom profile of Meniere's disease (MD) patients, particularly focusing on the cessation of episodic vertigo and the disease's longitudinal course and the impact of major symptoms on quality of life (QoL).MethodsThe study employed a cross-sectional design and was conducted on 365 out of 560 individuals with definite MD from the Finnish Vestibular and Meniere Federation, utilizing an internet-based questionnaire. Participants were surveyed on vertigo attacks, vestibular drop attacks (VDA), balance issues, selective cognitive complaints, hearing loss, and their effects on overall quality of life (QoL). The study population comprised 79.5% females and 20.5% males, with a mean age of 63 years and an average disease duration of 15.2 years.ResultsThe onset of MD was characterized by simultaneous hearing loss, vertigo, and tinnitus in 38% of participants. There was a significant delay in diagnosis for many, with 20% experiencing a delay of over 5 years. The frequency and duration of vertigo attacks generally decreased over time, with attacks becoming shorter and less severe as the disease progressed. Spontaneous remission from episodic vertigo occurred in 34% of participants variably throughout the course of MD. Of the participants 65.5% reported balance issues, and 34% experienced mild VDAs, with severe falls occurring in 10%. VDAs were more common with longer disease duration. Bilateral hearing loss developed in 34.5% of participants over the long term, with a higher risk associated with younger onset age, migraines, and family history of MD. Fatigue, anxiety, and depression were prevalent, particularly among younger participants. Cognitive impairments were linked to the severity of these symptoms and the presence of constant dizziness. QoL was significantly lower among participants with constant dizziness, with factors like fatigue, depression, VDA, and hearing loss contributing to this reduction.ConclusionsThe study highlights the complexity of MD. While vertigo may spontaneously remit, other symptoms such as VDAs, balance issues, cognitive complaints, and hearing loss often persist and worsen over time. Assessing MD solely on primary symptoms like vertigo and hearing loss is insufficient; a comprehensive evaluation is necessary for effective management.
Coffee consumption and alertness: a study among office workers in Jakarta
Authors: Herqutanto  , Rosemiarti Tria , Dewi Dian Kusuma , Soemarko Dewi Sumaryani , Syam Ari Fahrial 
Published: November 2024

BackgroundCoffee is widely consumed by office workers, primarily for its caffeine content, which plays an important role in improving alertness. For white-collar workers, alertness is crucial to maintaining productivity, and one measurable parameter of alertness is reaction time. Changes in reaction time can be classified as either shorter or longer compared to the initial measurement taken before coffee consumption, with a longer reaction indicating a decrease in alertness. The objective of this study is to investigate the relationship between coffee consumption and improvements in alertness.Materials and methodsThis cross-sectional study compared coffee drinkers and non-coffee drinkers, assessing their alertness using the Lakassidaya tool and collecting data on coffee consumption and caffeine intake through a 7-day fluid diary. Alertness was measured in the morning (baseline) and 30 min after coffee consumption (end line). Study participants were office workers from a company in Jakarta, Indonesia.ResultsA total of 121 participants completed the study, with 47.1% (n = 57) of them being coffee drinkers. No significant differences were found in the characteristics of the respondents. The average daily coffee consumption among these workers was 247 (157–391) mL/day, with a caffeine intake of 72 (36–121) mg/day, which was below the minimum amount typically required to trigger a positive alertness reaction. There was no significant association between coffee consumption and alertness (OR = 1.538, 95% CI: 0.288–1.467, p = 0.403), nor was there a significant difference in the change in reaction time between coffee drinkers and non-coffee drinkers (17.3 [1.4–32.2] ms vs. 13.0 [−3.9–26.0] ms, p-value = 0.111). However, there was a trend toward improved alertness in coffee drinkers, as indicated by shorter reaction times at baseline (180 [160–195.2] ms) compared to post-consumption (155 [146.6–170.2] ms).ConclusionThere was no significant association between coffee consumption and alertness improvement between coffee drinkers and non-coffee drinkers among office workers in Jakarta, Indonesia.
The ability of GLIM and MNA-FF to diagnose malnutrition and predict sarcopenia and frailty in hospitalized adults over 60 years of age
Authors: da Silva Gabriella D. , Batista Afra V. De A. , Costa Maria C. R. De A. , dos Santos Ana C. O. 
Published: November 2024

IntroductionMalnutrition remains common in adults over 60 years old. Although there are screening and diagnostic tools for malnutrition, there is no globally used approach to diagnosing malnutrition in older adults admitted to the hospital. In this study, we verified the agreement between the Global Leadership Initiative on Malnutrition (GLIM) and the Mini Nutritional Assessment (MNA) and the ability of the instruments to identify frailty and sarcopenia associated with malnutrition.MethodsFor adults over 60 years old, malnutrition diagnosis was performed using the Mini Nutritional Assessment Full Form (MNA-FF) tool and the GLIM criteria, which included calf circumference and fat-free mass index to assess muscle mass, with and without the Mini Nutritional Assessment Short Form (MNA-SF) screening. Health conditions were assessed in older adults, and the association of these conditions with malnutrition was analyzed using both tools.ResultsA total of 432 adults over 60 years old were investigated with a mean age of 71.14 ± 8 years. The GLIM criteria with the nutritional screening tool identified 61–63% of older adults as malnourished. Of these, 63–64% were severely malnourished. The MNA-FF tool classified 20% of those assessed as malnourished. The agreement between the MNA-FF and GLIM was better with the use of screening, with a kappa (K) value of −0.10 and − 0.11. Sarcopenia was associated with malnutrition as identified by the MNA-FF (OR: 3.08, 95% CI: 1.84–5.14) and only by the GLIM ANTHRO (OR: 1.66, 95% CI: 1.05–2.63). Frailty was associated with the MNA-FF (OR: 15.99, 95% CI: 2.16–118.36), GLIM ANTHRO (OR: 2.21, 95% CI: 1.31–3.71), and GLIM BIA (OR: 2.45, 95% CI: 1.45–4.12).ConclusionIt is possible to verify that divergent conceptual frameworks are used to understand malnutrition by the MNA-FF and GLIM and that the GLIM obtained a greater number of malnutrition diagnoses. Both the GLIM ANTHRO and the MNA-FF associated malnutrition with frailty and sarcopenia, with higher hazard ratios for the MNA-FF.
The association between the knowledge, perception, and practice of dietary supplement among Chinese adults
Authors: Tan Din Son , Wang Xijie , Zhao Xuechen , Zhao Ai 
Published: November 2024

IntroductionRapid growth has been found in the market of dietary supplements (DSs) in China. However, studies about the knowledge level, intentions, and behavior related to DS remained limited in the Chinese population. This study aimed to explore the knowledge level, perception, and practice toward DS among Chinese adults.MethodsThis is a cross-sectional design among 1,714 participants aged between 18 and 65 years. A total of 54.1% of participants reported purchasing supplements in the past 6 months. Knowledge levels were assessed with a score from 1 to 10 based on correct answers to 10 binary questions about supplements.ResultsOnly 29.1% of participants answered seven or more questions correctly, while 7.9% answered three or fewer questions correctly. Participants with high and middle knowledge levels were more likely to seek medical advice when experiencing discomfort symptoms and were less likely to choose DS, with corresponding odd ratios (ORs) of 1.58 (95% CI: 1.16, 2.13) and 0.69 (95% CI: 0.52, 0.91) in high knowledge group and ORs of 1.36 (95% CI: 1.03, 1.80) and 0.96 (95% CI: 0.72, 1.30) in middle knowledge group (Pfor trend = 0.003 and 0.028, respectively). No significant differences were found in the motivation of DS use between knowledge levels. Although higher knowledge levels were associated with less spending on DS (OR high = 0.69; 95% CI: 0.49, 0.99; OR middle = 0.88; 95% CI: 0.64, 1.20; Pfor trend = 0.038), it did not guarantee better and more accurate awareness toward DS use.DiscussionIn conclusion, there is a growing demand for supplements among Chinese adults, but a significant gap between knowledge and behavior exists, affecting decision-making behaviors regarding DS.
Comparative bioavailability study of supplemental oral Sucrosomial® vs. oral conventional vitamin B12 in enhancing circulatory B12 levels in healthy deficient adults: a multicentre, double-blind randomized clinical trial
Authors: Memon Nazia M. , Conti Gabriele , Brilli Elisa , Tarantino Germano , Chaudhry Muhammad N. A. , Baloch Ameeran , Shafiq Areaba , Mumtaz Sami U. , Qaisar Wafa , Iqtadar Somia , Abrar Saida , Kanwal Ayesha , Akhtar Muhammad H. , Latif Hina , Rabbani Fazle , Ujjan Ikram D. , Turroni Silvia , Khan Amjad 
Published: November 2024

BackgroundVitamin B12 is essential for neurological function, red blood cell formation, and DNA synthesis. Deficiency can lead to diverse health conditions, including megaloblastic anemia and neurological issues. Oral supplementation is a standard treatment for B12 deficiency. The Sucrosomial® carrier system offers an innovative approach that enhances supplemental nutrient absorption and bioavailability.ObjectivesThis study aimed to compare the effectiveness of oral Sucrosomial® vitamin B12 formulation vs various conventional B12 supplements, randomly selected from local pharmacies, in increasing and maintaining circulatory B12 levels in healthy deficient adults (200–300 pg/mL).MethodsA randomized, double-blind clinical trial was conducted across three centers in Pakistan from April to July 2024. At KEMU, participants received either Sucrosomial® vitamin B12 or Mecogen SL B12; at LRH, Sucrosomial® B12 or B-SUB B12; and at LUMHS, Sucrosomial® B12, Evermin B12, or Neuromax B12. Participants took a daily single dose of 1,000 μg of the assigned B12 formulation for 7 days. Serum B12 levels were measured at baseline (day 0) and on days 1, 3, 5, and 7.ResultsSucrosomial® B12 was significantly more effective than conventional B12 formulations in increasing and maintaining higher serum B12 levels across all time points. At KEMU, it reached a peak concentration of 454 ± 3.9 pg/mL by day 5, compared to 274 ± 11.1 pg/mL with Mecogen SL B12. At LRH, it peaked at 496 ± 34.4 pg/mL by day 5 versus 304 ± 49.4 pg/mL for B-SUB B12. At LUMHS, it reached 592.7 ± 74.3 pg/mL by day 7, compared to 407.24 ± 41.6 pg/mL for Evermin B12 and 263.82 ± 23.8 pg/mL for Neuromax B12. Sucrosomial® B12 was the only formulation to surpass the deficiency-borderline threshold (200–300 pg/mL) within 24 h of the first dose and was well tolerated with no reported side effects.ConclusionSucrosomial® vitamin B12 demonstrated superior efficacy in rapidly and consistently elevating and maintaining higher circulatory B12 levels compared to conventional supplements. Its characteristic absorption mode and proven efficacy suggest it could effectively address B12 deficiency in a broad range of populations, including those with gastrointestinal conditions and pernicious anemia, thereby supporting overall health.Clinical trial registrationclinicaltrials.gov, NCT06376591.
Mean platelet volume/platelet count ratio can predict the recurrence-free survival rate of patients after complete resection of gastrointestinal stromal tumors
Authors: Du Xinlian , Zang Xinxin , Zhang Hanbo , Liu Lijia , Xu Ying , Li Xuedong , Mou Ruishu , Xu Haitao , Zhu Jiuxin , Xie Rui 
Published: November 2024

PurposeThe aim of this study is to compare mean platelet volume/platelet count ratio (PVPR) and other indicators’ predictive abilities. Simultaneously, a new nomogram for predicting recurrence-free survival (RFS) after gastrointestinal stromal tumors (GISTs) R0 resection was developed.MethodsFrom January 2010 to July 2019, 295 patients with GIST who were operated on at Harbin Medical University Cancer Hospital were retrospectively reviewed. With a 4-year RFS as the end point, using the Kaplan–Meier methods and log rank test, and then conducting Cox regression analysis, we compared and identified meaningful indicators for predicting prognosis. Finally, a nomogram was developed and validated using calibration curves.ResultsThe receiver operating characteristic curve indicated that a cutoff point of 0.044 was the ideal threshold for PVPR, and patients were divided into a high-PVPR group (≤0.044) and a low-PVPR group (&gt;0.044). Kaplan–Meier curves suggested that PVPR&gt;0.044 had obvious associations with better RFS (p &lt; 0.001). In accordance with multivariate analysis, PVPR (&gt;0.044 vs. ≤0.044) (p = 0.005), National Institutes of Health (NIH) risk category (p &lt; 0.001), and Ki-67 (p = 0.005) were the independent prognostic indicators of RFS. Tumor size, gastrointestinal bleeding, mitotic index, NIH risk category, CD34, and Ki-67 all exhibited an obvious correlation with PVPR (all p &lt; 0.05). The nomogram’s probability of concordance was 0.823, indicating that the nomogram predictions were well calibrated.ConclusionIn GISTs, RFS can be independently predicted by PVPR. Patients with higher PVPR have better RFS. The nomogram including PVPR could be used to assist clinical treatment decision-making.
Mechanism of luteolin against non-small-cell lung cancer: a study based on network pharmacology, molecular docking, molecular dynamics simulation, and in vitro experiments
Authors: Zhang Jihang , Li Changling , Li Wenyi , Shi Zhenpeng , Liu Zhenguo , Zhou Junyu , Tang Jing , Ren Zixuan , Qiao Yun , Liu Deshan 
Published: November 2024

IntroductionLuteolin, a naturally occurring flavonoid compound, demonstrates promising anti-cancer properties. However, its mechanism against non-small-cell lung cancer (NSCLC) remains unknown. This study employed network pharmacology, molecular docking, molecular dynamics simulation (MDS), and in vitro experiments to investigate the potential mechanisms by which luteolin against NSCLC.MethodsInitially, the potential targets of luteolin and NSCLC-related targets were identified from public databases such as TCMSP, GeneCards, OMIM, DrugBank, and TTD. Subsequently, the protein-protein interaction (PPI) network screening and Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses were conducted. The binding affinity and stability of luteolin with the core targets were assessed using molecular docking and MDS. Finally, the results were validated by in vitro experiments.ResultsA total of 56 luteolin targets and 2145 NSCLC-related targets were identified. Six core targets, TP53, EGFR, AKT1, TNF, JUN, and CASP3, were screened via the PPI network. The GO and KEGG analyses indicated that luteolin’s activity against NSCLC potentially involves PI3K-Akt, NF-kappa B, and other signaling pathways. Molecular docking revealed that luteolin had high binding affinity with the core targets. MDS confirmed the stable interaction between luteolin and key proteins TP53 and AKT1. in vitro, luteolin significantly inhibited the proliferation and migration of A549 cells, while also inducing apoptosis. In addition, luteolin downregulated the expression of p-Akt (Ser473), MDM2, and Bcl-2 but upregulated the expression of p53 and Bax, which was consistent with the effect of LY294002.ConclusionLuteolin had a good anti-NSCLC effect, and the apoptosis-inducing effect might be related to the Akt/MDM2/p53 signaling pathway.
Video- assisted thoracoscopic lung resection with or without enhanced recovery after surgery: a single institution, prospective randomized controlled study
Authors: Ding Yi , Zhou Leiming , Shan Lei , Zhang Weiquan , Li Peichao , Cong Bo , Tian Zhongxian , Zhao Yunpeng , Zhao Xiaogang 
Published: November 2024

PurposeThis study was conducted to evaluate the postoperative short-term outcomes of patients undergoing video-assisted thoracoscopic surgery (VATS) for lung resection with the enhanced recovery after surgery (ERAS) protocol.MethodsA single-institution, prospective randomized controlled study was conducted. The primary outcome measures were postoperative pulmonary complications (PPCs) and postoperative short-term effects.ResultsAmong the 611 patients, 305 were assigned to the ERAS group, and 306 were assigned to the routine group. The ERAS group achieved earlier oral feeding, earlier mobilization, a shorter duration of drainage (2.0 vs. 5.0 days, P&lt;0.001), and a shorter hospital stay (3.0 vs. 7.0 days, P&lt;0.001). The biological impacts were confirmed to be significantly better for the ERAS group. Furthermore, the ERAS group also had a lower incidence of PPCs (11.5% vs. 22.9%, P&lt;0.001) than did the routine group. Multivariate logistic regression analysis revealed the following predictors of drainage tube removal on the 1st day after surgery without pneumonia during hospitalization: comorbidity (P=0.029), surgical procedure (P=0.001), and operation time (P=0.039).ConclusionsImplementation of the ERAS protocol led to a decreased incidence of PPCs, suggesting that the ERAS protocol has a better biological impact on patients undergoing VATS for lung resection. Multigradient individual ERAS protocols are recommended at different institutions according to the individual conditions of patients.Clinical Trial Registrationhttps://register.clinicaltrials.gov/prs/app/action/SelectProtocol?sid=S0009ZT9&amp;selectaction=Edit&amp;uid=U0002ZGN&amp;ts=3&amp;cx=ks7hrg, identifier NCT04451473.
The mediating role of cognitive flexibility in home–school co-education and psychological well-being among Chinese vocational college students
Authors: Liu Chao , Chen Hanjuan , Xu Wenping , Dai Shuling , Lin Shan 
Published: November 2024

ObjectiveThis study examines the mediating role of cognitive flexibility in the relationship between home-school co-education (H-SCE) and depressive symptom among vocational college students in urban and rural areas of China.MethodsUtilizing the Theory of Overlapping Spheres of Influence, this research explores how H-SCE influences depressive symptom, considering cognitive flexibility as a key mediating factor. The study utilized established scales, including the Inventory of Parent and Peer Attachment (IPPA) for parent-child relationships, the Student-Teacher Relationship Scale (STRS), the Cognitive Flexibility Inventory (CFI), and the Center for Epidemiologic Studies Depression Scale (CES-D10).ResultsA total of 1090 valid questionnaires were analyzed, revealing a significant negative correlation between H-SCE and depressive symptom. Cognitive flexibility was found to partially mediate this relationship, suggesting that enhanced cognitive adaptability, fostered through effective H-SCE, can reduce depressive symptom by helping students better cope with stressors.ConclusionThese findings underscore the importance of fostering strong collaboration between families and schools to enhance cognitive resilience and mitigate psychological challenges faced by vocational students, providing a foundation for targeted interventions to promote mental well-being.
Association between accompanying duration and anxiety/depression among family caregivers: a prospective cohort study in China during the COVID-19 pandemic
Authors: Jiang Yanhong , Hong Weiwen , Huang Lili , Ying Hongan , Hu Weiwei 
Published: November 2024

IntroductionWhile some studies have explored family caregivers’ anxiety and depression, limited research has been conducted on family caregivers’ anxiety and depression caused by the duration of companionship, resulting in an unclear relationship between the length of accompaniment and the psychological well-being of family caregivers.MethodsThis cohort study was conducted from April 1, 2022, to June 30, 2022 in general surgery. We employed bar graphs and line graphs to illustrate the relationship between accompanying days and anxiety and depression. Additionally, mixed-effects linear regression models were utilized to examine the correlation between accompanying days and the likelihood of anxiety and depression.ResultsThe study had 207 family caregivers, with 23.5% experiencing anxiety and 13.1% experiencing depression. Anxiety and depression scores peaked on day 9, and the incidence rate was the highest for the third group (≥10 days). Family caregivers in the first group (≤4 days) of companionship had significantly higher anxiety (β=0.27, 95% CI 0.16-0.39, p&lt;0.001 in all three models). Those in the second group (5-9 days) and the third group (≥10 days) showed no significant correlation with anxiety scores, except for a negative correlation in Model III (β=-0.15, 95% CI -0.29 to -0.01) for companionship in the third group (≥10 days). Family caregivers in the first group (≤4 days) of companionship had significantly higher depression scores (β=0.19, 95% CI 0.10-0.29, p&lt;0.001 in all three models). Those in the second group (5-9 days) had no significant relationship with depression, while those in the third group (≥10 days) exhibited a small negative correlation in Model II and III (β= -0.02, 95% CI -0.08-0.04). The sensitivity analysis confirms the mixed-effects linear regression findings.ConclusionThere was a positive correlation between the duration of family companionship and anxiety and depression in the early days.
Evaluating the applicability of landsat 8 data for global time series analysis
Authors: Rahimi Ehsan , Jung Chuleui 
Published: November 2024

IntroductionFactors such as (1) the number of satellite images available for a specific study and (2), the applicability of these images in terms of cloud cover, can reduce the overall accuracy of time series studies from earth observation. In this context, the Landsat 8 dataset stands out as one of the most widely used and versatile datasets for time series analysis, building on the strengths of its predecessors with its advanced features. However, despite these enhancements, there is a significant gap in the literature regarding a comprehensive assessment of Landsat 8’s performance. Specifically, there is a need for a detailed evaluation of image availability and cloud cover percentages across various global paths and rows.MethodsTo address this gap, we utilized the Landsat 8 Collection 2 dataset available through Google Earth Engine (GEE). Our approach involved filtering the dataset to focus on Landsat 8 images captured between 2014 and 2023 across all paths and rows. Using the Earth Engine Python API, we accessed and processed this data, extracting key information such as the number of available images and their associated cloud cover percentages.Results and DiscussionOur analysis of Landsat 8 image availability revealed that regions such as Australia, parts of Africa, the Middle East, Western Asia, and Southern North America benefit from a higher frequency of Landsat imagery, while Northern Asia and Northern North America have fewer images available. Latitude-specific trends show that areas between 55 and 82 degrees receive notably fewer images. We also found that regions like central Australia, northern Africa, and the Middle East generally experience lower cloud cover, while central Africa, and northern parts of Asia, Europe, and North America have higher cloudiness. Latitudinal trends show a significant drop in cloud cover from approximately 90% at latitudes -60 to -20 degrees to below 10%, with a rise near the Equator. Cloud cover decreases again from 0 to 20 degrees latitude but increases between 20 and 60 degrees. Europe has the highest average cloud cover at 42.5%, impacting image clarity, whereas Africa has the lowest average at 23.3%, indicating clearer satellite imagery.