bluuebunny/crossref_metadata_2025_split huggingface dataset:
Radar-Observed Characteristics of Precipitation in the Tropical High Andes of Southern Peru and Bolivia
Authors: Endries Jason L. , Perry L. Baker , Yuter Sandra E. , Seimon Anton , Andrade-Flores Marcos , Winkelmann Ronald , Quispe Nelson , Rado Maxwell , Montoya Nilton , Velarde Fernando , Arias Sandro 
Published: May 2018

AbstractThis study used the first detailed radar measurements of the vertical structure of precipitation obtained in the central Andes of southern Peru and Bolivia to investigate the diurnal cycle and vertical structure of precipitation and melting-layer heights in the tropical Andes. Vertically pointing 24.1-GHz Micro Rain Radars in Cusco, Peru (3350 m MSL, August 2014–February 2015), and La Paz, Bolivia (3440 m MSL, October 2015–February 2017), provided continuous 1-min profiles of reflectivity and Doppler velocity. The time–height data enabled the determination of precipitation timing, melting-layer heights, and the identification of convective and stratiform precipitation features. Rawinsonde data, hourly observations of meteorological variables, and satellite and reanalysis data provided additional insight into the characteristics of these precipitation events. The radar data revealed a diurnal cycle with frequent precipitation and higher rain rates in the afternoon and overnight. Short periods with strong convective cells occurred in several storms. Longer-duration events with stratiform precipitation structures were more common at night than in the afternoon. Backward air trajectories confirmed previous work indicating an Amazon basin origin of storm moisture. For the entire dataset, median melting-layer heights were above the altitude of nearby glacier termini approximately 17% of the time in Cusco and 30% of the time in La Paz, indicating that some precipitation was falling as rain rather than snow on nearby glacier surfaces. During the 2015–16 El Niño, almost half of storms in La Paz had melting layers above 5000 m MSL.
The Implications of an Idealized Large-Scale Circulation for Mechanical Work Done by Tropical Convection
Authors: Kamieniecki Jan A. , Ambaum Maarten H. P. , Plant Robert S. , Woolnough Steven J. 
Published: May 2018

Abstract
A thermodynamic analysis is presented of an overturning circulation simulated by two cloud-resolving models, coupled by a weak temperature gradient parameterization. Taken together, they represent two separated regions over different sea surface temperatures, and the coupling represents an idealized large-scale circulation such as the Walker circulation. It is demonstrated that a thermodynamic budget linking net heat input to the generation of mechanical energy can be partitioned into contributions from the large-scale interaction between the two regions, as represented by the weak temperature gradient approximation, and from convective motions in the active warm region and the suppressed cool region. Model results imply that such thermodynamic diagnostics for the aggregate system are barely affected by the strength of the coupling, even its introduction, or by the SST contrast between the regions. This indicates that the weak temperature gradient parameterization does not introduce anomalous thermodynamic behavior. We find that the vertical kinetic energy associated with the large-scale circulation is more than three orders of magnitude smaller than the typical vertical kinetic energy in each region. However, even with very weak coupling circulations, the contrast between the thermodynamic budget terms for the suppressed and active regions is strong and is relatively insensitive to the degree of the coupling. Additionally, scaling arguments are developed for the relative values of the terms in the mechanical energy budget.
The NCAR–NOAA Global Hawk Dropsonde System
Authors: Wick Gary A. , Hock Terrence F. , Neiman Paul J. , Vömel Holger , Black Michael L. , Spackman J. Ryan 
Published: May 2018

AbstractA new remotely controlled Airborne Vertical Atmospheric Profiling System (AVAPS) dropsonde system has been developed for and deployed on the NASA Global Hawk (GH) unmanned aircraft. Design, fabrication, and operation of the system was led by the National Center for Atmospheric Research (NCAR) with support from the National Oceanic and Atmospheric Administration (NOAA) Unmanned Aircraft Systems (UAS) Program. The system has employed the NCAR Research Dropsonde 94 (NRD94) dropsonde, a smaller and lighter version of the standard RD94 dropsonde deployed from manned aircraft but with virtually identical sensors. The dropsondes provide in situ atmospheric profiles of temperature, pressure, and humidity at a 2-Hz data rate, and wind speed and direction at 4 Hz. The system is capable of carrying up to 90 dropsondes and can support eight simultaneous soundings. Operation from the GH means that the dropsondes can be deployed from altitudes up to 19.8 km during flights in excess of 24-h duration. The dropsonde launch is commanded directly by an operator on the ground in coordination with the aircraft commander. Over 2700 total dropsondes have been deployed from the GH during four major campaigns since 2011. Data are processed in near–real time and have been employed by forecasters, for assimilation in numerical weather prediction models, and in diverse research studies. Intercomparison studies suggest the performance of the GH NRD94 dropsondes is similar to those deployed from manned aircraft. This paper describes the components and operation of the system and illustrates its unique capabilities through highlights of data application to research on the Arctic atmosphere, atmospheric rivers, and tropical cyclones.
Epidemiology of Elbow Ulnar Collateral Ligament Injuries Among Baseball Players: National Collegiate Athletic Association Injury Surveillance Program, 2009-2010 Through 2013-2014
Authors: DeFroda Steven F. , Goodman Avi D. , Gil Joseph A. , Owens Brett D. 
Published: May 2018

Background: Injuries to the ulnar collateral ligament (UCL) of the elbow are of major concern in baseball; however, the epidemiology of these injuries among National Collegiate Athletic Association (NCAA) athletes is poorly described. Purpose: To determine the incidence of UCL injuries in NCAA baseball and investigate the risk factors involved. Study Design: Descriptive epidemiology study. Methods: All UCL injuries for academic years 2009-2010 through 2013-2014 were extracted from the NCAA Injury Surveillance Program database. The incidence was calculated for different positions, activity, time in game, competition status, and injury characteristics and compared via injury risk ratios to determine risk factors for injury occurrence. The NCAA provides sampling weights based on division and year. For all other injury characteristic analysis, unweighted data were used. Results: Over the course of the 2009-2010 to 2013-2014, 20 UCL injuries were reported in the NCAA Injury Surveillance Program over 177,992 athletic exposures (AEs) for an overall incidence of 1.12 per 10,000 AEs (95% CI, 0.63-1.62). Eighty-five percent occurred during throwing, and 100% were new injuries. Of the injuries sustained during games, 28.6% occurred early (warm-up through third inning) and 71.4% late (fourth inning or later), with a risk ratio of 1.3 for late-game injuries (95% CI, 0.24-6.44). Of those injured, 45.0% were able to return to play by the next season, while the remainder were out for at least 7 days. Injury was season ending for 15% of athletes (0.17 per 10,000 AEs), and 15% of athletes required surgery. Conclusion: UCL injury is a potentially season-ending, even career-ending, injury among NCAA baseball players. Additionally, while more injuries occurred later in games, the current study revealed no significant difference in injury rates with respect to time in game. Last, the authors found a higher reported rate of extensive time away from sport after UCL injury than previously published studies on this patient population.
Outcomes of Reconstruction of the Stage II Adult-Acquired Flatfoot Deformity in Older Patients
Authors: Conti Matthew S. , Jones Mackenzie T. , Savenkov Oleksandr , Deland Jonathan T. , Ellis Scott J. 
Published: May 2018

Background: Reconstruction of the stage II adult-acquired flatfoot deformity (AAFD) often requires the use of multiple osteotomies and soft tissue procedures that may not heal well in older patients. The purpose of our study was to determine whether patients older than 65 years with stage II AAFD had inferior clinical outcomes or an increased number of subsequent surgical procedures after flatfoot reconstruction when compared with younger patients. Methods: One-hundred forty consecutive feet (70 right, 70 left) with stage II AAFD in 137 patients were divided into 3 groups based on age: younger than 45 years (young; n = 21), 45 to 65 years (middle-aged; n = 87), and 65 years and older (older; n = 32). Preoperative and postoperative Foot and Ankle Outcome Scores (FAOSs) at a minimum of 2 years were compared. Hospital records were reviewed to determine if patients underwent a subsequent procedure postoperatively. Results: Patients in the older group did not demonstrate any differences in changes in FAOS subscales compared with patients in the young and middle-aged groups (all P > .15). The older group had significant preoperative to postoperative improvements in all the FAOS subgroups ( P < .01). In addition, patients in the older group were not more likely to undergo a subsequent surgery than were the younger patients (all P > .10). Conclusions: Our study found that patients older than 65 years with stage II AAFD have improvements in patient-reported outcomes and rates of revision surgery after surgical reconstruction that were not significantly different than those of younger patients. Level of Evidence: Therapeutic Level III, comparative series.
Time to Diagnosis and Treatment of Surgical Site Infections in Foot and Ankle Surgery
Authors: Baranek Eric S. , Tantigate Direk , Jang Eugene , Greisberg Justin K. , Vosseller J. Turner 
Published: May 2018

Background: The time at which patients typically present with surgical site infections (SSI) following foot and ankle surgery has not been characterized. The primary aim of this study was to quantify the time to definitive treatment of SSIs. Methods: We performed a retrospective review of 1933 foot and ankle procedures in 1632 patients from 2011 through 2015. Demographic and surgical data were collected. Time to presentation in cases diagnosed with postoperative wound complications or SSIs was analyzed. Wound complications were defined as any case with concerning wound appearance that subsequently resolved with antibiotic therapy alone. SSIs were defined as cases requiring operative irrigation and debridement (I&D) for successful definitive management. Results: A total of 1569 procedures met inclusion criteria, with 17 SSIs (1.1%) and 63 wound complications (4.0%). Time between surgery and definitive treatment in the SSI group was significantly greater than in the wound complication group (28.2 ± 9.1 vs 13.4 ± 4.7 days, P < .00001). Eleven (64.7%) cases in the SSI group failed a trial of antibiotics prior to I&D, and 6 (35.3%) cases did not receive antibiotics prior to I&D. Antibiotic treatment prior to I&D did not significantly decrease the yield of intraoperative wound cultures (70% vs 100%, P = .51). Conclusion: In our cohort of patients, the time to diagnosis and treatment of SSIs was longer than that of wound complications. SSIs requiring operative intervention did not present until an average of 4 weeks after surgery. These data are of some benefit in trying to define and understand SSI. Level of Evidence: Level III, retrospective cohort study.
Evaluation of Articular Cartilage Injury Using Computed Tomography With Axial Traction in the Ankle Joint
Authors: Nakasa Tomoyuki , Ikuta Yasunari , Sawa Mikiya , Yoshikawa Masahiro , Tsuyuguchi Yusuke , Ota Yuki , Kanemitsu Munekazu , Adachi Nobuo 
Published: May 2018

Background: Although chondral or osteochondral injuries are usually assessed by magnetic resonance imaging, its accuracy can be low, presumably related to the relatively thin cartilage layer and the close apposition of the cartilage of the talus and tibial plafond. We hypothesized that axial traction could provide a contrast between the articular cartilage and joint cavity, and it enabled the simultaneous evaluation of cartilage and subchondral bone. The purpose of this study was to assess the feasibility of using computed tomography (CT) imaging with axial traction for the diagnosis of articular cartilage injuries. Methods: Chondral lesions in 18 ankles were evaluated by CT with axial traction using a tensioning device and ankle strap for enlargement of the joint space of the ankle. CT was done in 3-mm slices and programmed for gray scale, and then CT images were allocated colors to make it easier to evaluate the cartilage layer. The International Cartilage Repair Society (ICRS) grades on CT were compared with those on arthroscopic findings. Results: The respective sensitivity and specificity of CT imaging with traction using ICRS grading were 74.4%, and 96.3%. The level of agreement of the ICRS grading between CT images and arthroscopic findings was moderate (kappa coefficient, 0.547). Adding axial traction to CT increased the delineation of the cartilage surface, including chondral thinning, chondral defect, and cartilage separation. Conclusions: CT with axial traction produced acceptable levels of sensitivity and specificity for the evaluation of articular cartilage injuries, in addition to the assessment of subchondral bone. Level of Evidence: Level III, comparative case series.
CSF inflammatory biomarkers responsive to treatment in progressive multiple sclerosis capture residual inflammation associated with axonal damage
Authors: Romme Christensen Jeppe , Komori Mika , von Essen Marina Rode , Ratzer Rikke , Börnsen Lars , Bielekova Bibi , Sellebjerg Finn 
Published: May 2018

Background: Development of treatments for progressive multiple sclerosis (MS) is challenged by the lack of sensitive and treatment-responsive biomarkers of intrathecal inflammation. Objective: To validate the responsiveness of cerebrospinal fluid (CSF) inflammatory biomarkers to treatment with natalizumab and methylprednisolone in progressive MS and to examine the relationship between CSF inflammatory and tissue damage biomarkers. Methods: CSF samples from two open-label phase II trials of natalizumab and methylprednisolone in primary and secondary progressive MS. CSF concentrations of 20 inflammatory biomarkers and CSF biomarkers of axonal damage (neurofilament light chain (NFL)) and demyelination were analysed using electrochemiluminescent assay and enzyme-linked immunosorbent assay (ELISA). Results: In all, 17 natalizumab- and 23 methylprednisolone-treated patients had paired CSF samples. CSF sCD27 displayed superior standardised response means and highly significant decreases during both natalizumab and methylprednisolone treatment; however, post-treatment levels remained above healthy donor reference levels. Correlation analyses of CSF inflammatory biomarkers and NFL before, during and after treatment demonstrated that CSF sCD27 consistently correlates with NFL. Conclusion: These findings validate CSF sCD27 as a responsive and sensitive biomarker of intrathecal inflammation in progressive MS, capturing residual inflammation after treatment. Importantly, CSF sCD27 correlates with NFL, consistent with residual inflammation after anti-inflammatory treatment being associated with axonal damage.
Rates and causes of 30-day readmission and emergency room utilization following head and neck surgery
Authors: Wu Vincent , Hall Stephen F. 
Published: May 2018

Background Unplanned returns to hospital are common, costly, and potentially avoidable. We aimed to investigate and characterize reasons for all-cause readmissions to hospital as in-patients (IPs) and visits to the Emergency Department (ED) within 30-days following patient discharge post head and neck surgery (HNS). Methods Retrospective case series with chart review. All patients within the Department of Otolaryngology – Head and Neck Surgery who underwent HNS for benign and malignant disease from January 1, 2010 to May 31, 2015 were identified. The electronic medical records of readmitted patients were reviewed for reasons of readmission, demographic data, and comorbidities. Results Following 1281 surgical cases, there were 41 (3.20%) IP readmissions and 109 (8.43%) ED visits within 30-days after discharge for HNS. For IP readmissions, most common causes included infection (26.8%), respiratory symptoms (17.1%), and pain (17.1%). Most common reasons for ED visits were for pain (31.5%), bleeding (17.6%), and infection (14.8%). Readmitted IPs had significantly higher health burden at pre-operative baseline as compared to patients who visited the ED when assessed with the American Society of Anesthesiology scores ( p = 0.002) and the Cumulative Illness Rating Scale ( p = 0.004). Conclusion Rate of 30-day IP readmission and ED utilization was 3.20 and 8.43%, respectively. Pain and infection were common causes for returns to hospital. Discharge planning may be improved to target common causes for post-surgical hospital visits in order to decrease readmission rates.
Integrated X-ray fluorescence and diffuse visible-to-near-infrared reflectance scanner for standoff elemental and molecular spectroscopic imaging of paints and works on paper
Authors: Delaney John K. , Conover Damon M. , Dooley Kathryn A. , Glinsman Lisha , Janssens Koen , Loew Murray 
Published: May 2018

Abstract
Prior studies have shown the improved ability to identify artists’ pigments by combining results from X-ray fluorescence (XRF), which provides elemental information, with reflectance spectroscopy in the visible to near infrared (400–1000 nm) that provides information on electronic transitions. Extending the spectral range of reflectance spectroscopy into the UV, 350–400 nm, allows identification of several white pigments since their electronic transitions occur in this region (e.g., zinc white and rutile and anatase forms of titanium white). Extending the range further into the infrared, out to 2500 nm, provides information on vibrational transitions of various functional groups, such as hydroxyl, carbonate, and methyl groups. This allows better identification of mineral-based pigments and some paint binders. The combination of elemental information with electronic and vibrational transitions provides a more robust method to identify artists’ materials in situ. The collection of both sets of spectral information across works of art, such as paintings and works on paper, allows generating a more complete map of artists’ materials. Here, we describe a 2-D scanner that simultaneously collects XRF spectra and reflectance spectra from 350 to 2500 nm across the surfaces of works of art. The scanner consists of a stationary, single pixel XRF spectrometer and fiber optic reflectance spectrometer along with a 2-D position-controlled easel that moves the artwork in front of the two detection systems. The dual-mode scanner has been tested on a variety of works of art from illuminated manuscripts (0.1 × 0.1 m2) to paintings as large as 1.7 × 1.9 m2. The scanner is described and two sets of results are presented. The first is the XRF scanning of a large warped panel painting by Andrea del Sarto titled Charity. The second is a combined XRF and reflectance scan of Georges Seurat’s painting titled Haymakers at Montfermeil. The XRF was collected at 1 mm spatial sampling and the reflectance spectral data at 3 mm. Combining the results from the data sets was found to enhance the identification of pigments as well as yield distribution maps, in spite of the relatively low reflectance spatial sampling. The elemental and reflectance maps allowed the identification and mapping of lead white, cobalt blue, viridian, ochres, and likely chrome yellow. The maps also provide information on the mixing of pigments. While the reflectance image cube has 10–20× larger spatial samples than desired, the elimination of having to use two hyperspectral cameras to cover the range from 400 to 2500 nm makes for a low cost dual modality scanner.
Effectiveness of Prenatal Vitamin D Deficiency Screening and Treatment Program: A Stratified Randomized Field Trial
Authors: Rostami Maryam , Tehrani Fahimeh Ramezani , Simbar Masoumeh , Bidhendi Yarandi Razieh , Minooee Sonia , Hollis Bruce W , Hosseinpanah Farhad 
Published: May 2018

Abstract

Context
Despite evidence on the association between hypovitaminosis D and adverse pregnancy outcomes and the positive impact of vitamin D supplementation, no evidence exists supporting a universal screening program in pregnancy as part of routine prenatal care.

Objective
We sought to determine the effectiveness of a prenatal screening program on optimizing 25-hydroxyvitamin D [25(OH)D] levels and preventing pregnancy complications. Also, to identify a safe regimen, we compared several regimens in a subgroup of vitamin D–deficient pregnant women.

Design
Two cities of Masjed-Soleyman and Shushtar from Khuzestan province, Iran, were selected as the screening and nonscreening arms, respectively. Within the screening arm, a randomized controlled trial was conducted on 800 pregnant women.

Setting
Health centers of Masjed-Soleyman and Shushtar cities.

Patients or Participants
Pregnant women aged 18 to 40 years.

Intervention
Women with moderate [25(OH)D, 10 to 20 ng/mL] and severe [25(OH)D, &lt;10 ng/mL] deficiency were randomly divided into four subgroups and received vitamin D3 (D3) until delivery.

Main Outcome Measure
Maternal concentration of 25(OH)D at delivery and rate of pregnancy complications

Results
After supplementation, only 2% of the women in the nonscreening site met the sufficiency level (&gt;20 ng/mL) vs 53% of the women in the screening site. Adverse pregnancy outcomes, including preeclampsia, gestational diabetes mellitus, and preterm delivery, were decreased by 60%, 50%, and 40%, respectively, in the screening site. A D3 injection in addition to monthly 50,000 IU maintenance therapy contributed the most to achievement of sufficient levels at delivery.

Conclusions
A prenatal vitamin D screening and treatment program is an effective approach in detecting deficient women, improving 25(OH)D levels, and decreasing pregnancy adverse outcomes.
Mechanical stability of the cell nucleus – roles played by the cytoskeleton in nuclear deformation and strain recovery
Authors: Wang Xian , Liu Haijiao , Zhu Min , Cao Changhong , Xu Zhensong , Tsatskis Yonit , Lau Kimberly , Kuok Chikin , Filleter Tobin , McNeill Helen , Simmons Craig A. , Hopyan Sevan , Sun Yu 
Published: May 2018

ABSTRACT
Extracellular forces transmitted through the cytoskeleton can deform the cell nucleus. Large nuclear deformations increase the risk of disrupting the integrity of the nuclear envelope and causing DNA damage. The mechanical stability of the nucleus defines its capability to maintain nuclear shape by minimizing nuclear deformation and allowing strain to be minimized when deformed. Understanding the deformation and recovery behavior of the nucleus requires characterization of nuclear viscoelastic properties. Here, we quantified the decoupled viscoelastic parameters of the cell membrane, cytoskeleton, and the nucleus. The results indicate that the cytoskeleton enhances nuclear mechanical stability by lowering the effective deformability of the nucleus while maintaining nuclear sensitivity to mechanical stimuli. Additionally, the cytoskeleton decreases the strain energy release rate of the nucleus and might thus prevent shape change-induced structural damage to chromatin.