bluuebunny/crossref_metadata_2025_split huggingface dataset:
3D-printing of dipyridamole/thermoplastic polyurethane materials for bone regeneration
Authors: Adhami Masoud , Dastidar Anushree Ghosh , Anjani Qonita Kurnia , Detamornrat Usanee , Tarrés Quim , Delgado-Aguilar Marc , Acheson Jonathan G. , Manda Krishnagoud , Clarke Susan A. , Moreno-Castellanos Natalia , Larrañeta Eneko , Domínguez-Robles Juan 
Published: November 2024

AbstractTissue engineering combines biology and engineering to develop constructs for repairing or replacing damaged tissues. Over the last few years, this field has seen significant advancements, particularly in bone tissue engineering. 3D printing has revolutionised this field, allowing the fabrication of patient- or defect-specific scaffolds to enhance bone regeneration, thus providing a personalised approach that offers unique control over the shape, size, and structure of 3D-printed constructs. Accordingly, thermoplastic polyurethane (TPU)-based 3D-printed scaffolds loaded with dipyridamole (DIP) were manufactured to evaluate their in vitro osteogenic capacity. The fabricated DIP-loaded TPU-based scaffolds were fully characterised, and their physical and mechanical properties analysed. Moreover, the DIP release profile, the biocompatibility of scaffolds with murine calvaria-derived pre-osteoblastic cells, and the intracellular alkaline phosphatase (ALP) assay to verify osteogenic ability were evaluated. The results suggested that these materials offered an attractive option for preparing bone scaffolds due to their mechanical properties. Indeed, the addition of DIP in concentrations up to 10% did not influence the compression modulus. Moreover, DIP-loaded scaffolds containing the highest DIP cargo (10% w/w) were able to provide sustained drug release for up to 30 days. Furthermore, cell viability, proliferation, and osteogenesis of MC3T3-E1 cells were significantly increased with the highest DIP cargo (10% w/w) compared to the control samples. These promising results suggest that DIP-loaded TPU-based scaffolds may enhance bone regeneration. Combined with the flexibility of 3D printing, this approach has the potential to enable the creation of customized scaffolds tailored to patients’ needs at the point of care in the future.
Graphical Abstract
Prophylactic vs preemptive strategy for the prevention of CMV disease in solid organ transplant recipients: systematic review and meta-analysis of randomized controlled trials
Authors: Reiss-Gindi Niv , Hoffman Tomer , Ruderman Tanya , Atamna Alaa , Margalit Ili , Yahav Dafna 
Published: November 2024

Abstract
Purpose
Cytomegalovirus (CMV) is associated with significant morbidity and mortality among solid organ transplant (SOT) recipients. Strategies for CMV prevention include universal prophylaxis or preemptive approach. We aimed to evaluate the optimal approach.

Methods
We performed a systematic review and meta-analysis of randomized controlled trials comparing prophylaxis versus preemptive therapy for CMV in SOT. The primary outcome was CMV disease. Subgroup analysis of outcomes in D+ R− patients was performed.

Results
Nine trials have met inclusion criteria, five of them included kidney transplant recipients, all compared val/ganciclovir universal prophylaxis versus preemptive approach. Universal prophylaxis resulted in lower probability of CMV infection (relative risk [RR] 0.44, 95% confidence interval [CI] 0.33–0.58), yet the impact on CMV disease was insignificant (RR 0.54, 95% CI 0.24–1.23), in neither SOT recipients in general nor among D+R− subgroup (RR 0.93, 95% CI 0.37–2.32). Late-onset CMV disease rates were lower with preemptive approach. Sensitivity analysis according to allocation concealment and blinding showed similar results for CMV disease. No significant differences were demonstrated for the outcomes of mortality, bacterial or fungal infection or graft related outcomes. Acute kidney injury was significantly more common with prophylaxis (RR 1.79, 95% CI 1.12–2.89).

Conclusion
Preemptive approach is a reasonable approach for CMV prevention in SOT recipients, if feasible. Strategies for combining the preemptive with prophylaxis strategies, as well as immune monitoring, should be investigated.
Eazygoma technique: a new approach for zygomatic implant placement aligned with maxillomalar anatomy
Authors: Aldana Avila Henry Alexander , Geithner Carlos Miguel Ruiz 
Published: November 2024

AbstractThis study focused on evaluating the novel Eazygoma method for zygomatic implant placement. This approach focuses on biomechanical principles, offering direct visualization that facilitates enhanced control during implant insertion. It helps prevent malpositioning, ensuring that the apical portion remains within the zygomatic body and achieves emergence in the alveolar crest through an inverted drilling sequence. The Eazygoma system enables improved control during drilling, starting in the zygomatic area and eliminating the need for osteotomies in the maxillary sinus. This not only simplifies the procedure but also significantly reduces the operative time, allowing it to be performed under local anesthesia and sedation in approximately one hour, according to the author’s experience. The study included 34 zygomatic implants placed in 11 patients with severe maxillary atrophy, treated between 2021 and 2023 at the Maxillofacial surgery Department of the private clinic “Clínica Colsanitas” in Bogotá, Colombia. To evaluate outcomes, intraoperative torque, surgical time, and whether alveolar emergence was achieved were measured for the implants. Patients were followed up at 12 months to assess implant survival. Results showed that the Eazygoma approach eliminated postoperative sinus injuries and implant malposition, ensuring alveolar emergence and achieving a torque greater than 50 Newtons in all cases, allowing for immediate implant loading.
A survey on localization and energy efficiency in UWSN: bio-inspired approach
Authors: Murali J. , Shankar T. 
Published: November 2024

AbstractThe underwater wireless sensor networks (UWSNs) area is a developing area of research since there are tremendous opportunities like surveying marine life, installing and monitoring optical cables, detecting earthquakes, and surveillance of territorial borders. Though many applications exist, underwater research explored to date is less than five percent as it poses many issues and challenges like water currents, temperature, pressure, water salinity, disturbance by aquatic animals, and many more factors that affect the performance of sensors deployed inside water. A significant issue UWSNs face is focusing on energy efficiency to extend the life of submerged sensors placed in isolated areas. Resolving localization concerns is a primary additional concern. In this comprehensive survey, the basics of UWSNs are covered in the introduction, followed by a thorough literature review of the existing works mainly focusing on localization, energy efficiency, Bio-inspired algorithms (BIA), and the impact of implementing Machine Learning (ML) are discussed. In concurrent sections, we have discussed attributes, parameters useful for analysis, issues and challenges in UWSN, soft computing techniques, software and hardware tools available for extended research, and opportunities in UWSN. The researchers could gain perspective pathways at the end of this survey.
Integration of confocal chromatic spectroscopy into a test bench concept for safety inspection practices, with focus on stress detection
Authors: Bauer Constantin , Ramadani Joel , Bikardt Daniel , Nguyen Long Kiet , Steinlehner Florian , Volk Wolfram 
Published: November 2024

AbstractEvaluating casting’s mechanical stress is of significant interest from a safety inspection’s point of view. Residual stress, in particular, leads to an early or even immediate failure of some parts. Therefore, several methods exist to determine casting’s external and internal strain leading to stress. By determining the state of stress and residual stress, it is possible to design casting parts that are much safer. The present concept of a test bench shows a new way of inspecting parts for safety reasons using an optical fiber confocal chromatic sensor to measure strain. The method is based on the deep-drilling method, where a minimal invasive hole is placed at an area of interest in the first step. In a second step, this hole is then precisely measured to be able to map the borehole. From this information, conclusions can be drawn of any forces acting on the inspected part. In this case, the concept of the test bench uses gun drills to place boreholes measuring 6.0 mm in diameter with up to 500.0 mm in depth, and for the inspection, a confocal sensor with a precision of ± 100.0 nm in dissolving distances is used. This work focuses on evaluating the test bench’s precision in conducting such measurements and on how an external thermal load and mechanical load influence the results when conducting differential measurements. The experiments are performed on typical cast alloys such as iron cast and Zamac.
Development of an RNA virus vector for non-transgenic genome editing in tobacco and generation of berberine bridge enzyme-like mutants with reduced nicotine content
Authors: Xiang Haiying , Chen Binhuan , Wang Shuo , Zeng Wanli , Jiang Jiarui , Kong Weisong , Huang Haitao , Mi Qili , Ni Shuang , Gao Qian , Li Zhenghe 
Published: November 2024

AbstractTobacco (Nicotiana tabacum) plants synthesize the psychoactive pyridine alkaloid nicotine, which has sparked growing interest in reducing nicotine levels through genome editing aiming at inactivating key biosynthetic genes. Although stable transformation-mediated genome editing is effective in tobacco, its polyploid nature complicates the complete knockout of genes and the segregation of transgenes from edited plants. In this study, we developed a non-transgenic genome editing method in tobacco by delivering the CRISPR/Cas machinery via an engineered negative-strand RNA rhabdovirus vector, followed by the regeneration of mutant plants through tissue culture. Using this method, we targeted six berberine bridge enzyme-like protein (BBL) family genes for mutagenesis, which are implicated in the last steps of pyridine alkaloid biosynthesis, in the commercial tobacco cultivar Hongda. We generated a panel of 16 mutant lines that were homozygous for mutations in various combinations of BBL genes. Alkaloid profiling revealed that lines homozygous for BBLa and BBLb mutations exhibited drastically reduced nicotine levels, while other BBL members played a minor role in nicotine synthesis. The decline of nicotine content in these lines was accompanied by reductions in anatabine and cotinine levels but increases in nornicotine and its derivative myosmine. Preliminary agronomic evaluation identified two low-nicotine lines with growth phenotypes comparable to those of wild-type plants under greenhouse and field conditions. Our work provides potentially valuable genetic materials for breeding low-nicotine tobacco and enhances our understanding of alkaloid biosynthesis.
Predictors of willingness to participate in COVID-19 clinical trials among Black and Latino adults
Authors: Weston Christine M. , Andrade Elizabeth L. , Olawole Wuraola , Guerrero Vazquez Monica , Miller Hailey , Stevens Sarah C. , Lacanienta Cyd , Perrin Nancy , Edberg Mark C. , Mellman Thomas A. , Bronner Yvonne , Clark Roger , Dennison Himmelfarb Cheryl R. 
Published: November 2024

Abstract

Introduction:
Black and Latino individuals are underrepresented in COVID-19 treatment and vaccine clinical trials, calling for an examination of factors that may predict willingness to participate in trials.

Methods:
We administered the Common Survey 2.0 developed by the Community Engagement Alliance (CEAL) Against COVID-19 Disparities to 600 Black and Latino adults in Baltimore City, Prince George’s County, Maryland, Montgomery County, Maryland, and Washington, DC, between October and December 2021. We examined the relationship between awareness of clinical trials, social determinants of health challenges, trust in COVID-19 clinical trial information sources, and willingness to participate in COVID-19 treatment and vaccine trials using multinomial regression analysis.

Results:
Approximately half of Black and Latino respondents were unwilling to participate in COVID-19 treatment or vaccine clinical trials. Results showed that increased trust in COVID-19 clinical trial information sources and trial awareness were associated with greater willingness to participate in COVID-19 treatment and vaccine trials among Black and Latino individuals. For Latino respondents, having recently experienced more challenges related to social determinants of health was associated with a decreased likelihood of willingness to participate in COVID-19 vaccine trials.

Conclusions:
The willingness of Black and Latino adults to participate in COVID-19 treatment and vaccine clinical trials is influenced by trial awareness and trust in trial information sources. Ensuring the inclusion of these communities in clinical trials will require approaches that build greater awareness and trust.
Should we communicate with the dead to assuage our grief? An Ubuntu perspective on using griefbots
Authors: Wright Connor 
Published: November 2024

Abstract
During the 20th century, dealing with grief through an ongoing involvement with the deceased (such as speaking to their grave) was seen as pathological by Western authors such as Sigmund Freud. Nowadays, we are presented with the opportunity to continue interacting with digital representations of the deceased. As a result, the paper adopts an Ubuntu perspective, i.e., a sub-Saharan African philosophy focussed on community and relationship to provide a toolkit for using this emerging technology. I will argue that the Ubuntu framework I propose contributes to the use of griefbots in two ways. The first is that it shows that it is morally permissible to use griefbots to assuage our grief. The second is that it delineates how we can ethically use the technology. To do so, I split my analysis into four sections. In the first section, I show that meaningful relationships can occur between the bereaved and griefbots. This will be done by exploring the Western theory of continuing bonds proposed by Dennis Klass, Phyllis Silverman and Steven Nickman. In my second, I flesh out my Ubuntu framework according to Thaddeus Metz’s accounts on Ubuntu as a modal-relational theory. In my third section, I apply my Ubuntu framework to the case of Roman Mazurenko. Furthermore, I consider some counterarguments to the Ubuntu framework regarding privacy, commercialisation and people replacement. Finally, I conclude that, despite these limitations, the Ubuntu framework positively contributes to determining whether we should communicate with the dead through griefbots to assuage our grief.
A high-accuracy ionospheric foF2 critical frequency forecast using long short-term memory LSTM
Authors: Denisenko-Floyd Alexandra , Yucel Meric , Ustundag Burak Berk 
Published: November 2024

Abstract
Due to the F2 ionospheric layer’s ability to reflect radio waves, the foF2 critical frequency is essential since sudden irregularities can disrupt communication and navigation systems, affecting the weather forecast’s accuracy. This paper aims to develop accurate foF2 critical frequency prediction up to 24 hours ahead, focusing on mid and high latitudes, using the long short-term memory (LSTM) model covering the 24th solar cycle from 2008 to 2019. To evaluate the effectiveness of the proposed model, a comparative analysis is conducted with commonly referenced machine learning techniques, including linear regression, decision tree algorithms, and multilayer perceptron (MLP) using the Taylor diagram and error plots. The study involved five monitoring stations, different years with minimum and maximum solar activity, and prediction timeframes. Through extensive experimentation, a comprehensive set of outcomes is evaluated across diverse metrics. The findings conclusively established that the LSTM model has demonstrated superior performance compared to the other models across all stations and years. On average, LSTM is 1.2 times better than the second-best model (DT), 1.6 times as effective as the multilayer perceptron MLP, and three times more accurate than linear regression. The results of this research hold promise for increasing the precision of foF2-prediction, with potential implications for enhancing communication systems and weather forecasting capabilities.
Butyrate attenuates high-fat diet-induced glomerulopathy through GPR43-Sirt3 pathway
Authors: Shi Ying , Xing Lin , Zheng Ruoyi , Luo Xin , Yue Fangzhi , Xiang Xingwei , Qiu Anqi , Xie Junyan , Russell Ryan , Zhang Dongmei 
Published: November 2024

AbstractThe incidence of obesity-related glomerulopathy (ORG) is rising worldwide with very limited treatment methods. Paralleled with the gut–kidney axis theory, the beneficial effects of butyrate, one of the short-chain fatty acids (SCFA) produced by gut microbiota, on metabolism and certain kidney diseases have gained growing attention. However, the effects of butyrate on ORG and its underlying mechanism are largely unexplored. In this study, a mice model of ORG was established with a high-fat diet feeding for 16 weeks, and sodium butyrate treatment was initiated at the 8th week. Podocyte injury, oxidative stress and mitochondria function were evaluated in mice kidney and validated in vitro in palmitic acid-treated-mouse podocyte cell lines. Further, the molecular mechanisms of butyrate on podocytes were explored. Compared with controls, sodium butyrate treatment alleviated kidney injuries and renal oxidative stress in high-fat diet-fed mice. In mouse podocyte cell lines, butyrate ameliorated palmitic acid-induced podocyte damage and helped maintain the structure and function of the mitochondria. Moreover, the effects of butyrate on podocytes were mediated via the GPR43-Sirt3 signal pathway, as evidenced by the diminished effects of butyrate with the intervention of GPR43 or Sirt3 inhibitors. In summary, we conclude that butyrate has therapeutic potential for the treatment of ORG. It attenuates high-fat diet-induced ORG and podocyte injuries through the activation of the GPR43-Sirt3 signalling pathway.
Existence and non-existence results for a class of systems under concave-convex nonlinearities
Authors: Pinheiro Da Silva João Pablo 
Published: November 2024

AbstractIn this work, we are interested in studying the following class of problems:
(𝒫λμ)\begin{align}
\left\{
\begin{array}{ll}
-\Delta u=f_\lambda(x,u,v)& \text{in}~~\Omega\\
-\Delta v=g_\mu(x,u,v) & \text{in}~~\Omega\\
0\not\equiv u\geq 0,\,\,0\not\equiv v\geq 0& \text{in}~~\Omega\\
u=v=0&\text{on}~~\partial\Omega
\end{array}
\right.
\end{align} where Ω is a bounded domain in $\mathbb{R}^N$, λ > 0, µ > 0, $t\mapsto f_\lambda(x,t,t)$ and $t\mapsto g_\mu(x,t,t)$ have concave-convex type nonlinearities. We present results related to the existence and non-existence of solutions for problem $(\mathcal{P}_{\lambda\mu})$.
Defect relation for holomorphic maps from complex discs into projective varieties and hypersurfaces
Authors: Duc Quang Si 
Published: November 2024

AbstractIn this paper, we establish a second main theorem for holomorphic maps with finite growth index on complex discs intersecting arbitrary families of hypersurfaces (fixed and moving) in projective varieties, which gives an above bound of the sum of truncated defects. Our result also generalizes and improves many previous second main theorems for holomorphic maps from ${\mathbb{C}}$ intersecting hypersurfaces (moving and fixed) in projective varieties.
Continuing the momentum of developmental psychopathology: Lessons learned from the seminal contributions of Dante Cicchetti
Authors: Pollak Seth D. 
Published: November 2024

AbstractThe field of developmental psychopathology has grown broadly. Here, I draw upon lessons learned from Dante Cicchetti to highlight areas that show promise for continued disciplinary advancement. These include attention to equifinality and multifinality in the conceptualization of initial study designs, and more emphasis on specificity in accounting for developmental change. A shift from reliance on external events and towards greater diversity of research approaches will allow researchers to devote attention to the variety of ways that individuals come to understand and then respond to their own life experiences. The field of developmental psychopathology holds tremendous promise for advancing basic science about human development that can be applied to create interventions that improve the well-being of individuals and address significant societal issues.
Early dehiscence of a tricuspid valve annuloplasty ring in an adolescent with hypoplastic left heart syndrome presenting with unconjugated hyperbilirubinemia
Authors: Kielmayer David , Sames-Dolzer Eva , Tulzer Gerald 
Published: November 2024

AbstractWe report a unique case of an adolescent patient with Fontan physiology presenting with unconjugated hyperbilirubinemia due to dehiscence of a tricuspid valve annuloplasty ring.
Elevating diversity, inclusion, and health equity in Pediatric Heart Network Scholars grant funding: unique opportunities and lessons learned
Authors: Wallace Michelle C. , Minich L. LuAnn , Shekerdemian Lara S. , Bauser-Heaton Holly , Chowdhury Shahryar M. , Czosek Richard J. , Freud Lindsay R. , Goldberg David J. , Gurvitz Michelle , Lopez Leo , Schumacher Kurt R. , Scott Jane , Slayton Beverly , Lopez Keila N. 
Published: November 2024

AbstractThere is a growing awareness that diversity, health equity, and inclusion play a significant role in improving patient outcomes and advancing knowledge. The Pediatric Heart Network launched an initiative to incorporate diversity, health equity, and inclusion into its 2021 Scholar Award Funding Opportunity Announcement. This manuscript describes the process of incorporating diversity, health equity, and inclusion into the Pediatric Heart Network Scholar Award and the lessons learned. Recommendations for future Pediatric Heart Network grant application cycles are made which could be replicated by other funding agencies.