bluuebunny/crossref_metadata_2025_split huggingface dataset:
Predictors of early response in conjoint and separated models of family‐based treatment for adolescent anorexia nervosa
Authors: Hughes Elizabeth K. , Sawyer Susan M. , Accurso Erin C. , Singh Simar , Le Grange Daniel 
Published: February 2019

AbstractObjectiveEarly response, as indicated by early weight gain, in family‐based treatment (FBT) for adolescent anorexia nervosa (AN) predicts remission at end of treatment. However, little is known about what factors contribute to early response. Further, no previous studies have examined early response to separated forms of FBT.MethodData from a randomised clinical trial of conjoint FBT and separated FBT (parent‐focused treatment, PFT) were analysed to examine the timing and amount of early weight gain that predicted remission and identify factors associated with early response.ResultsWeight gain of at least 2.80 kg in FBT (N = 55) and 2.28 kg in PFT (N = 51), by Session 5, were the best predictors of remission at end of treatment. Early response in FBT was predicted by greater paternal therapeutic alliance and lower paternal criticism. Early response in PFT was predicted by less severe eating‐disorder symptoms and negative affect at baseline, lower maternal criticism, and greater adolescent therapeutic alliance.ConclusionsThe results confirm that early weight gain is an important prognostic indicator in both conjoint FBT and PFT and suggest that addressing negative emotion, parental criticism, and therapeutic alliance early in treatment could improve remission rates.
On the wireless virtualization with QoE constraints
Authors: Rawat Danda B. , Alsulami Bassma Saleh , Chaudhary Vijay 
Published: February 2019

AbstractWireless virtualization is emerging as a new paradigm to improve wireless spectrum utilization by subleasing radio frequency (RF) channels through slicing. This paper investigates wireless virtualization where wireless resources for virtual wireless networks adapted based on availability of leasable RF slices as well as the demands from the users of virtual wireless networks. The user utilities are subject to quality‐of‐experience requirements such as coverage, rate, mobility, and delay requirements. With the help of software defined network controller, wireless infrastructure providers (WIPs) slice their RF bands to sublease those slices to mobile virtual network operators (MVNOs). In wireless virtualization, MVNOs work as independent service provides, and thus, the end users negotiate directly to MVNOs regardless of WIPs used behind the scene (this concept is analogous to the Uber being a taxi company without owning any vehicles). The performance of the proposed approach is evaluated with the help of numerical results obtained from simulations by using different metrics such as percentage of RF band of WIP, outage probability, and data rate.
Power‐efficient D2D relaying cellular network access
Authors: Pan Yijin , Chen Ming , Huang Nuo , Wang Yinlu 
Published: February 2019

AbstractDevice‐to‐device (D2D) communications are exploited in this paper to assist remote user equipments (UEs) access the cellular network with reduced energy consumption. A power‐efficient relay selection criterion is proposed to guarantee that the power saved by D2D relaying access exceeds a given threshold. Then, the relay selection criterion is equivalently transformed into a region constraint, based on which the success probability of D2D relaying access is derived. Furthermore, the power consumption of D2D relaying access is analyzed in two stages: the stage from the remote UE to the relaying UE and the stage from the relaying UE to the base station. The calculation of the average power consumption requires a double integral over the plane, and the closed‐form expression is derived by applying the Green's theorem and proper variable substitutions. Finally, simulation results validate the analytical derivations and present the impacts of system parameters on the performance of D2D relaying access in terms of the success probability and power consumption.
Palaeozoic diorites from the south‐western Dunhuang terrane, NW China: Constraints on tectonic evolution of southernmost CAOB
Authors: Zhu Tao , Wang Hongliang , Zhao Yan , Xu Xueyi , Li Zhipei 
Published: February 2019

The petrology, geochemistry, zircon U–Pb geochronology, and Hf isotopes of Duobagou diorite and Karatashtage diorite were studied to establish the evolution of Palaeozoic orogeny in the Dunhuang area in Western China. The weighted mean 206Pb/238U age of 448 ± 2 Ma in zircon grains from Duobagou diorite indicated an origin in the late Ordovician Period; age‐corrected εHf(t) values of −0.98 to +4.46 correspond to a two‐stage zircon Hf model age (TDM2) of 1,145 Ma to 1,477 Ma. Karatashtage diorite has a weighted mean 206Pb/238U age of 436 ± 3 Ma, indicating an origin in the early Silurian Period; age‐corrected εHf(t) values of −1.13 to +7.96 correspond to a two‐stage zircon Hf model age (TDM2) of 718 Ma to 1,301 Ma. These findings indicate that Duobagou and Karatashtage diorites were derived from ancient crust. Duobagou diorite has high levels of Al2O3 (15.76%~17.64%), MgO (2.18%~5.44%), Mg# (40~51), Na2O (2.78%~4.19%), Sr (466~1,160 ppm), and Ba (523~892 ppm), low levels of K2O (1.29%~3.13%) and TiO2 (0.64%~1.0%), variable levels of Cr (73.4~253 ppm) and Ni (42.2~98.8 ppm), and depleted HREEs. Karatashtage diorite is characterized by high levels of Al2O3 (16.33%~17.59%), MgO (4.15%~7.10%), Mg# (50~59), Na2O (3.39%~4.41%), Cr (73.4~253 ppm), Ni (42.2~98.8 ppm), Sr (466~1,160 ppm), and Ba (523~892 ppm), low levels of K2O (1.29%~3.13%) and TiO2 (0.64%~1.0%), and depleted HREEs. The Duobagou pluton and the Karatashtage pluton display arc signatures, suggesting that they were formed by the partial melting of a subducted slab under garnet–amphibolite facies in an active continental margin, and an interaction between melt and mantle materials during emplacement. Subduction of the oceanic plate in the Dunhuang terrane occurred during the Early Silurian Period (435–430 Ma), which is close to that of the Beishan orogenesis but later than the formation of the Hongliugou–Lapeiquan ophiolitic belt. We suggest that the Dunhuang terrane underwent an orogenic process related to the Palaeo‐Asian Ocean during the Early Palaeozoic Era, and that it belongs to the Central Asian Orogenic Belt (CAOB).
Early Carboniferous mafic dike–syenitic granite association in the Atengtao Mountain, Yili Block (NW China): Geochronology, petrogenesis, and tectonic significance
Authors: Wang Zuopeng , Li Yongjun , Yang Gaoxue , Zhang Yuling , Zhang Chao , Luo Yaoqing , Wang Weining , Teng Mingyao 
Published: February 2019

The Carboniferous is an important period for understanding tectonic evolutionary history and subduction processes of Chinese western Tianshan orogen. Here, we present results of petrologic, geochemical, and in situ LA‐ICP‐MS zircon U–Pb and Hf isotope data from an Early Carboniferous mafic dike–syenitic granite association in Atengtao Mountain, Yili Block, aiming to constrain their ages and petrogenesis and tectonic significance. Zircon U–Pb dating results reveal that the mafic dikes and syenitic granites were coevally emplaced at ca. 345–349 Ma. Geochemically, the mafic dikes contain high MgO, Nb, TiO2, and Ta contents, low SiO2 contents, and high Na2O/K2O ratios, showing Nb‐enriched affinities. Additionally, they are enriched in LILEs, relatively depleted in HFSEs, and positive εHf(t) values (+1.2 to +8.7), likely representing melts derived from partial melting of a depleted mantle wedge metasomatized by subducted slab‐derived fluids, with minor involvement of asthenospheric components. Compared with mafic dikes, the coeval syenitic granites display calc‐alkaline I‐type features and have high SiO2, Al2O3, and low MgO, Mg# (<40), Ni, and Cr contents, considered to have been derived from the reworking of the Precambrian basement with an input of mantle‐derived components. These mafic dike–syenitic granite associations likely formed in an arc‐related setting rather than postcollision or mantle plume setting. In addition, pronouncedly higher zircon saturation temperature of the syenitic granites, compared with the coeval I‐type granitoids from western Tianshan, imply the occurrence of a thermal anomaly in this period (ca. 345 Ma). With these studied results, together with previously published data, we argue that a slab break‐off model was likely responsible for the mafic dike–syenitic granite association, and related rocks, in the western Yili Block during Early Carboniferous.
Anticholinergic burden before and after hospitalization in older adults with dementia: Increase due to antipsychotic medications
Authors: Reinold Jonas , Palese Francesca , Romanese Federico , Logroscino Giancarlo , Riedel Oliver , Pisa Federica E. 
Published: February 2019

ObjectivesTo evaluate changes in the use of antipsychotics and medications with anticholinergic activity (MACs) during hospitalization in older adults with dementia and factors associated with antipsychotic prescriptions and increased anticholinergic burden (ACB).Methods and designThis retrospective cohort study included all patients aged 65 years or older with a discharge diagnosis of dementia hospitalized at the university hospital of Udine, Italy, from 2012 to 2014. Medications dispensed within 3 months before and after hospitalization were identified in community‐pharmacy dispensations while those prescribed at discharge were collected from Hospital Electronic Medical Records (EMR). ACB was assessed using the Anticholinergic Cognitive Burden score.ResultsAmong 1908 patients included, at discharge, 37.0% used one or more antipsychotic (9.4% before and 12.6% after hospitalization), 68.6% used one or more MAC (49.1% and 45.7%, respectively), and ACB of 38.4% of patients increased at discharge mainly because of a higher use of antipsychotics with anticholinergic activity (33% at discharge vs 12% before hospitalization). Prescription of antipsychotics at discharge was associated with prior treatment with antipsychotics (adjusted odds ratio [aOR] 4.85; 95%CI, 3.37‐6.97), psychiatric conditions, (4.39; 3.47‐5.54) and discharge from surgical department (2.17; 1.32‐3.55). An increased ACB was associated with psychiatric conditions (1.91; 1.52‐2.39), discharge from surgical (1.75; 1.09‐2.80) or medical department (1.50; 1.04‐2.17), and with cardiac insufficiency (1.41; 1.00‐1.99).ConclusionsACB was higher at discharge, and antipsychotics were the main drivers of this increase. Clinicians treating older adults with dementia should be aware of the risks associated with antipsychotics and that some of these medications may increase the risk of anticholinergic effects.
Parts‐based representations of perceived face movements in the superior temporal sulcus
Authors: Deen Ben , Saxe Rebecca 
Published: February 2019

AbstractFacial motion is a primary source of social information about other humans. Prior fMRI studies have identified regions of the superior temporal sulcus (STS) that respond specifically to perceived face movements (termed fSTS), but little is known about the nature of motion representations in these regions. Here we use fMRI and multivoxel pattern analysis to characterize the representational content of the fSTS. Participants viewed a set of specific eye and mouth movements, as well as combined eye and mouth movements. Our results demonstrate that fSTS response patterns contain information about face movements, including subtle distinctions between types of eye and mouth movements. These representations generalize across the actor performing the movement, and across small differences in visual position. Critically, patterns of response to combined movements could be well predicted by linear combinations of responses to individual eye and mouth movements, pointing to a parts‐based representation of complex face movements. These results indicate that the fSTS plays an intermediate role in the process of inferring social content from visually perceived face movements, containing a representation that is sufficiently abstract to generalize across low‐level visual details, but still tied to the kinematics of face part movements.
Long‐term functional and esthetic outcomes after fibula free flap reconstruction of the mandible
Authors: Petrovic Ivana , Baser Raymond , Blackwell Timothy , McCarthy Colleen , Ganly Ian , Patel Snehal , Cordeiro Peter , Shah Jatin 
Published: February 2019

AbstractBackgroundThe goal of this study is to report functional and esthetic outcomes, after fibula free flap (FFF) reconstruction of the mandible for oral cancer, assessed by physicians, nonclinicians, and patients.MethodsTwenty‐five long‐term survivors from oral cancer after FFF reconstruction were recalled for head and neck examination by surgeons, for photographs and patient‐reported outcomes, using EORTC, QLQ‐C30, H&N35, and FACE‐Q questionnaires.ResultsPhysicians reported 64% restoration of functionality compared to normal. Patients reported high scores on QLQ‐C30 but lower scores on H&N35. Esthetic scores were reported higher by clinicians than nonclinicians. The decline in function and appearance was attributed to loss of lower dentition, trismus, malocclusion, xerostomia, and tissue atrophy.ConclusionTo minimize the decline in function and appearance, immediate dental implants in FFF, better reconstruction of the temporomandibular joint, newer methods of radiotherapy to minimize xerostomia and oral exercises to prevent trismus should be considered.
Parotidectomy in patients with head and neck cutaneous melanoma with cervical lymph node involvement
Authors: Berger Danique M.S. , van Veen Martinus M. , Madu Max F. , van Akkooi Alexander C.J. , Vogel Wouter V. , Balm Alfons J.M. , Klop Willem M.C. 
Published: February 2019

AbstractBackgroundParotidectomy in melanoma of the coronal scalp and face with clinically involved cervical lymph node metastasis is based on predicted cervical lymphatic drainage described by O'Brien.MethodsIn total, 40 parotidectomies with en bloc therapeutic neck dissection were retrospectively analyzed.ResultsLymphatic spread of melanoma to the parotid lymph nodes was observed in 10 of 40 specimens (25%). Eight of the 10 parotid‐positive patients developed a recurrence vs 17 of the 30 parotid‐negative patients (P = 0.28). There were no differences in overall survival, melanoma‐specific survival, and disease‐free survival between the parotid‐positive and parotid‐negative patients.ConclusionAlthough in this series no survival differences were found, parotidectomy still merits a sustained role in therapeutic neck dissection procedures to improve regional control and to prevent facial nerve damage after surgery for a second relapse from occult metastases in the parotid.
Predicting glottal closure insufficiency using fundamental frequency contour analysis
Authors: Cohen Jacob T. , Cohen Alma , Benyamini Limor , Adi Yossi , Keshet Joseph 
Published: February 2019

AbstractBackgroundVoice analysis has a limited role in a day‐to‐day voice clinic. We developed objective measurements of vocal folds (VF) glottal closure insufficiency (GCI) during phonation.MethodsWe examined 18 subjects with no history of voice impairment and 20 patients with unilateral VF paralysis before and after injection medialization laryngoplasty. Voice analysis was extracted. We measured settling time, slope, and area under the fundamental frequency curve from the phonation onset to its settling‐time.ResultsThe measured parameters, settling time, slope, and area under the curve were in correlation with the traditional acoustic voice assessments and clinical findings before treatment and after injection medialization laryngoplasty.ConclusionWe found that the fundamental frequency curve has several typical contours which correspond to different glottal closure conditions. We proposed a new set of parameters that captures the contour type, and showed that they could be used to quantitatively assess individuals with GCI.
Lusutrombopag for the Treatment of Thrombocytopenia in Patients With Chronic Liver Disease Undergoing Invasive Procedures (L‐PLUS 2)
Authors: Peck‐Radosavljevic Markus , Simon Krzysztof , Iacobellis Angelo , Hassanein Tarek , Kayali Zeid , Tran Albert , Makara Mihaly , Ben Ari Ziv , Braun Marius , Mitrut Paul , Yang Sheng‐Shun , Akdogan Meral , Pirisi Mario , Duggal Ajay , Ochiai Toshimitsu , Motomiya Tomoko , Kano Takeshi , Nagata Tsutae , Afdhal Nezam 
Published: February 2019

Thrombocytopenia may be associated with increased bleeding risk impacting timing and outcome of invasive procedures in patients with chronic liver disease (CLD). Lusutrombopag, a small‐molecule, thrombopoietin (TPO) receptor agonist, was evaluated as a treatment to raise platelet counts (PCs) in patients with thrombocytopenia and CLD undergoing invasive procedures. L‐PLUS 2 was a global, phase 3, randomized, double‐blind, placebo‐controlled study. Adults with CLD and baseline PCs < 50 × 109/L were randomized to receive once‐daily lusutrombopag 3 mg or placebo ≤ 7 days before an invasive procedure scheduled 2‐7 days after the last dose. The primary endpoint was avoidance of preprocedure platelet transfusion and avoidance of rescue therapy for bleeding. A key secondary endpoint was number of days PCs were ≥ 50 × 109/L throughout the study. Safety analysis was performed on patients who received at least one dose of study drug. This study occurred between June 15, 2015, and April 19, 2017, with a total of 215 randomized patients (lusutrombopag, 108; placebo, 107); 64.8% (70/108) of patients in the lusutrombopag group versus 29.0% (31/107) in the placebo group met the primary endpoint (P < 0.0001; difference of proportion 95% confidence interval [CI], 36.7 [24.9, 48.5]). The median duration of PCs ≥ 50 × 109/L was 19.2 days with lusutrombopag (without platelet transfusion) compared with 0.0 in the placebo group (with platelet transfusion) (P = 0.0001). Most adverse events were mild or moderate in severity, and rates were similar in the lusutrombopag and placebo groups (47.7% and 48.6%, respectively). Conclusion: Lusutrombopag was superior to placebo for reducing the need for platelet transfusions and achieved durable PC response in patients with thrombocytopenia and CLD undergoing invasive procedures, with a safety profile similar to placebo.
Identifying the health problems of slum residents using social determinants of health: Kerman, Iran
Authors: Nekoei‐Moghadam Mahmood , Heidari Narges , Amiresmaeili Mohammadreza , Heidarijamebozorgi Majid 
Published: February 2019

SummaryIntroductionAlthough slum emerged in industrialized countries, today, all cities in the world are somehow facing this phenomenon. Slums create many problems in different areas, especially health for residents. Therefore, this research was conducted with the aim of identifying the health problems of the slum residents of Kerman city by using the social determinant of health approach.MethodThe present study is an applied study that was carried out qualitatively using semistructured interviews. Samples were selected using purposeful and snowball sampling methods. Data were analyzed using the Colaizy method.ResultsIn this study, the health problems of residents of slums in the city of Kerman were identified by interviews. In total, seven main themes and 32 sub‐themes were extracted. The main concepts extracted include the economic and social class, the early childhood development, social exclusion and social support, employment and unemployment, addiction, food, transport, and traffic.ConclusionThe problems of slums people are very widespread, and almost all of the problems affect the health of slums people. The place of living, job, income, the early childhood development and nutritional status are determinants that affect people's health.
Single‐institution retrospective review of patients with recurrent glioblastoma treated with bevacizumab in clinical practice
Authors: Desjardins Annick , Herndon James E. , McSherry Frances , Ravelo Arliene , Lipp Eric S. , Healy Patrick , Peters Katherine B. , Sampson John H. , Randazzo Dina , Sommer Nicolas , Friedman Allan H. , Friedman Henry S. 
Published: February 2019

AbstractBackground and aimsThis retrospective review of patients with recurrent glioblastoma treated at the Preston Robert Tisch Brain Tumor Center investigated treatment patterns, survival, and safety with bevacizumab in a real‐world setting.MethodsAdult patients with glioblastoma who initiated bevacizumab at disease progression between January 1, 2009, and May 14, 2012, were included. A Kaplan‐Meier estimator was used to describe overall survival (OS), progression‐free survival (PFS), and time to greater than or equal to 20% reduction in Karnofsky Performance Status (KPS). The effect of baseline demographic and clinical factors on survival was examined using a Cox proportional hazards model. Adverse event (AE) data were collected.ResultsSeventy‐four patients, with a median age of 59 years, were included in this cohort. Between bevacizumab initiation and first failure, defined as the first disease progression after bevacizumab initiation, biweekly bevacizumab and bevacizumab/irinotecan were the most frequently prescribed regimens. Median duration of bevacizumab treatment until failure was 6.4 months (range, 0.5‐58.7). Median OS and PFS from bevacizumab initiation were 11.1 months (95% confidence interval [CI], 7.3‐13.4) and 6.4 months (95% CI, 3.9‐8.5), respectively. Median time to greater than or equal to 20% reduction in KPS was 29.3 months (95% CI, 13.8‐∞). Lack of corticosteroid usage at the start of bevacizumab therapy was associated with both longer OS and PFS, with a median OS of 13.2 months (95% CI, 8.6‐16.6) in patients who did not initially require corticosteroids versus 7.2 months (95% CI, 4.8‐12.5) in those who did (P = 0.0382, log‐rank), while median PFS values were 8.6 months (95% CI, 4.6‐9.7) and 3.7 months (95% CI, 2.7‐6.6), respectively (P = 0.0243, log‐rank). Treatment failure occurred in 70 patients; 47 of whom received salvage therapy, and most frequently bevacizumab/carboplatin (7/47; 14.9%). Thirteen patients (18%) experienced a grade 3 AE of special interest for bevacizumab.ConclusionsTreatment patterns and outcomes for patients with recurrent glioblastoma receiving bevacizumab in a real‐world setting were comparable with those reported in prospective clinical trials.