bluuebunny/crossref_metadata_2025_split huggingface dataset:
Design, Synthesis, and Cholinesterase Inhibition Assay of Coumarin‐3‐carboxamide‐N‐morpholine Hybrids as New Anti‐Alzheimer Agents
Authors: Tehrani Maliheh Barazandeh , Rezaei Zahra , Asadi Mehdi , Behnammanesh Hossein , Nadri Hamid , Afsharirad Fatemeh , Moradi Alireza , Larijani Bagher , Mohammadi‐Khanaposhtani Maryam , Mahdavi Mohammad 
Published: June 2019

AbstractA new series of coumarin‐3‐carboxamide‐N‐morpholine hybrids 5a–5l was designed and synthesized as cholinesterases inhibitors. The synthetic approach for title compounds was started from the reaction between 2‐hydroxybenzaldehyde derivatives and Meldrum's acid to afford corresponding coumarin‐3‐carboxylic acids. Then, amidation of the latter compounds with 2‐morpholinoethylamine or N‐(3‐aminopropyl)morpholine led to the formation of the compounds 5a–5l. The in vitro inhibition screen against acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) revealed that most of the synthesized compounds had potent AChE inhibitory while their BuChE inhibitions are moderate to weak. Among them, propylmorpholine derivative 5g (N‐[3‐(morpholin‐4‐yl)propyl]‐2‐oxo‐2H‐chromene‐3‐carboxamide) bearing an unsubstituted coumarin moiety and ethylmorpholine derivative 5d (6‐bromo‐N‐[2‐(morpholin‐4‐yl)ethyl]‐2‐oxo‐2H‐chromene‐3‐carboxamide) bearing a 6‐bromocoumarin moiety showed the most activity against AChE and BuChE, respectively. The inhibitory activity of compound 5g against AChE was 1.78 times more than that of rivastigmine and anti‐BuChE activity of compound 5d is approximately same as rivastigmine. Kinetic and docking studies confirmed the dual binding site ability of compound 5g to inhibit AChE.
Palladium(II)‐Based Self‐Assembled Heteroleptic Coordination Architectures: A Growing Family
Authors: Bardhan Devjanee , Chand Dillip Kumar 
Published: June 2019

AbstractMetal‐driven self‐assembly is one of the most effective approaches to lucidly design a large range of discrete 2D and 3D coordination architectures/complexes. Palladium(II)‐based self‐assembled coordination architectures are usually prepared by using suitable metal components, in either a partially protected form (PdL′) or typical form (Pd; charges are not shown), and designed ligand components. The self‐assembled molecules prepared by using a metal component and only one type of bi‐ or polydentate ligand (L) can be classified in the homoleptic series of complexes. On the other hand, the less explored heteroleptic series of complexes are obtained by using a metal component and at least two different types of non‐chelating bi‐ or polydentate ligands (such as La and Lb). Methods that allow the controlled generation of single, discrete heteroleptic complexes are less understood. A survey of palladium(II)‐based self‐assembled coordination cages that are heteroleptic has been made. This review article illustrates a systematic collection of such architectures and credible justification of their formation, along with reported functional aspects of the complexes. The collected heteroleptic assemblies are classified here into three sections: 1) [(PdL′)m(La)x(Lb)y]‐type complexes, in which the denticity of La and Lb is equal; 2) [(PdL′)m(La)x(Lb)y]‐type complexes, in which the denticity of La and Lb is different; and 3) [Pdm(La)x(Lb)y]‐type complexes, in which the denticity of La and Lb is equal. Representative examples of some important homoleptic architectures are also provided, wherever possible, to set a background for a better understanding of the related heteroleptic versions. The purpose of this review is to pave the way for the construction of several unique heteroleptic coordination assemblies that might exhibit emergent supramolecular functions.
PIDAZTA: Structurally Constrained Chelators for the Efficient Formation of Stable Gallium‐68 Complexes at Physiological pH
Authors: Farkas Edit , Vágner Adrienn , Negri Roberto , Lattuada Luciano , Tóth Imre , Colombo Valentina , Esteban‐Gómez David , Platas‐Iglesias Carlos , Notni Johannes , Baranyai Zsolt , Giovenzana Giovanni B. 
Published: May 2019

AbstractTwo structurally constrained chelators based on a fused bicyclic scaffold, 4‐amino‐4‐methylperhydro‐pyrido[1,2‐a][1,4]diazepin‐N,N′,N′‐triacetic acids [(4R*,10aS*)‐PIDAZTA (L1) and (4R*,10aR*)‐PIDAZTA (L2)], were designed for the preparation of GaIII‐based radiopharmaceuticals. The stereochemistry of the ligand scaffold has a deep impact on the properties of the complexes, with unexpected [Ga(L2)OH] species being superior in terms of both thermodynamic stability and inertness. This peculiar behavior was rationalized on the basis of molecular modeling and appears to be related to a better fit in size of GaIII into the cavity of L2. Fast and efficient formation of the GaIII chelates at room temperature was observed at pH values between 7 and 8, which enables 68Ga radiolabeling under truly physiological conditions (pH 7.4).
Sulfation Patterns of Saccharides and Heavy Metal Ion Binding
Authors: Alshanski Israel , Blaszkiewicz Joanna , Mervinetsky Evgeniy , Rademann Jörg , Yitzchaik Shlomo , Hurevich Mattan 
Published: June 2019

AbstractSulfated saccharides are an essential part of extracellular matrices, and they are involved in a large number of interactions. Sulfated saccharide matrices in organisms accumulate heavy metal ions in addition to other essential metal ions. Accumulation of heavy metal ions alters the function of the organisms and cells, resulting in severe and irreversible damage. The effect of the sulfation pattern of saccharides on heavy metal binding preferences is enigmatic because the accessibility to structurally defined sulfated saccharides is limited and because standard analytical techniques cannot be used to quantify these interactions. We developed a new strategy that combines enzymatic and chemical synthesis with surface chemistry and label‐free electrochemical sensing to study the interactions between well‐defined sulfated saccharides and heavy metal ions. By using these tools we showed that the sulfation pattern of hyaluronic acid governs their heavy metal ions binding preferences.
Contrasting Effect of Additives on Photoinduced Reactions of SmI2
Authors: Nimkar Amey , Maity Sandeepan , Flowers Robert A , Hoz Shmaryahu 
Published: May 2019

AbstractThe work described herein compares the effect of additives (HMPA, methanol, ethylene glycol, pinacol, N‐methylethanolamine) on thermal and photochemical reactions of samarium diiodide (SmI2). In thermal reactions, additives that coordinate to SmI2 induce a significant increase in reaction rate. In photochemical reactions, the presence of an electronegative atom with a highly localized negative charge on the substrate leads to a rate deceleration. In order to benefit from the columbic interaction with the positively charged samarium cation, these substrates react preferentially by an inner sphere reduction mechanism. The addition of ligands prevents this close interaction causing rate retardation. Furthermore, studies demonstrate that excited state quenching of SmII by ethylene glycol and other additives indicate that it is unlikely to be the major cause for the observed rate retardation. This effect provides a simple diagnostic tool to distinguish between an inner and an outer sphere reduction mechanism.
Alkali Phosphonate Metal–Organic Frameworks
Authors: Maares Maria , Ayhan M. Menaf , Yu Kai. B. , Yazaydin A. Ozgur , Harmandar Kevser , Haase Hajo , Beckmann Jens , Zorlu Yunus , Yücesan Gündoğ 
Published: June 2019

AbstractA new family of porous metal–organic frameworks (MOFs), namely alkali phosphonate MOFs, is reported. [Na2Cu(H4TPPA)]⋅(NH2(CH3)2)2 (GTUB‐1) was synthesized using the tetratopic 5,10,15,20‐tetrakis[p‐phenylphosphonic acid] porphyrin (H8‐TPPA) linker with planar X‐shaped geometrical core. GTUB‐1 is composed of rectangular void channels with BET surface area of 697 m2 g−1. GTUB‐1 exhibits exceptional thermal stability. The toxicity analysis of the (H8‐TPPA) linker indicates that it is well tolerated by an intestinal cell line, suggesting its suitability for creating phosphonate MOFs for biological applications.
Im Spinnturm der ITA
Authors: Kallweit Jan , Brüll Robert , Gries Thomas 
Published: June 2019

AbstractDer Bereich „Technical Fibres“ des Instituts für Textiltechnik der RWTH Aachen (ITA) ist weltweit führend in industrieorientierter Forschung im Schmelzspinnen. Der Bereich versteht sich als weltweit erste Anlaufstelle für innovative Fasern mit den Schwerpunkten Recycling, Prozessoptimierung, Materialentwicklung und Funktionalisierung.
Pinpointing the Genomic Localizations of Chromatin‐Associated Proteins: The Yesterday, Today, and Tomorrow of ChIP‐seq
Authors: Lloyd Sarah M. , Bao Xiaomin 
Published: June 2019

AbstractChromatin‐associated proteins are instrumental for controlling spatiotemporal gene expression. Determining where these proteins bind across the genome is critical for understanding gene regulation. A widely used technique at present is ChIP‐seq, which leverages chromatin fragmentation, antibody‐mediated enrichment, next‐generation sequencing, and data analysis to uncover the genomic sequences and patterns of protein‐DNA interactions. In this article, we will provide an overview of how ChIP‐seq was developed, the key elements of the experimentation and data analysis pipeline, and the recent variations that push the boundaries of precision and cell number requirements. We will also briefly discuss how future development of ChIP‐seq may further advance our understanding of chromatin biology. © 2019 by John Wiley & Sons, Inc.
The wave concept iterative process (WCIP) method for electrical circuit network with triangular and hexagonal topology
Authors: Ammar Noemen , Baudrand Henri 
Published: June 2019

SummaryThis paper deals with an RLC circuit network with triangular or hexagonal grid. It is about a planar equilateral triangular grid where the passive (resistor, capacitor, and inductor) or active (voltage source for example) components are located at the sides or/and at nodes attached to the ground. The planar graph is oriented by three main direction vectors phase shifted to 60° degrees. The wave concept iterative process (WCIP) method was employed to the theoretical formulation of the problem. In the formulation, the potential difference across each circuit component is represented by an auxiliary source defined in the spectral domain. The proposed theory is developed into two definition domains: a spectral domain in which periodicity and coupling between the circuit components are defined and a spatial domain describing the network topology and imposing the continuities conditions (Kirchhoff laws). The transition between the spectral and spatial domain is ensured by the so‐called fast hexagonal Fourier transform. Numerical applications demonstrate the ability of the method for solving the inhomogeneous triangular lattices. Various conceptions have been proposed including an RL, RC, and RLC triangular network circuit, a perturbed triangular RLC circuit, and a triangular circuit excited by many lumped sources.
Seeking shelter from the storm: Conservation and management of imperiled species in a changing climate
Authors: Walls Susan C. , Barichivich William J. , Chandler Jonathan , Meade Ashley M. , Milinichik Marysa , O'Donnell Katherine M. , Owens Megan E. , Peacock Terry , Reinman Joseph , Watling Rebecca C. , Wetsch Olivia E. 
Published: May 2019

AbstractClimate change is anticipated to exacerbate the extinction risk of species whose persistence is already compromised by habitat loss, invasive species, disease, or other stressors. In coastal areas of the southeastern United States (USA), many imperiled vertebrates are vulnerable to hurricanes, which climate models predict to become more severe in the 21st century. Despite this escalating threat, explicit adaptation strategies that address hurricane threats, in particular, and climate change more generally, are largely underrepresented in recovery planning and implementation. We provide a basis for stronger emphasis on strategic planning for imperiled species facing the increasing threat of catastrophic hurricanes. Our reasoning comes from observations of short‐term environmental and biological impacts of Hurricane Michael, which impacted the Gulf Coast of the southeastern USA in October 2018. During this storm, St. Marks National Wildlife Refuge, located along the northern Gulf of Mexico's coast in the panhandle region of Florida, received storm surge that was 3.0–3.6 m (NAVD88) above sea level. Storm surge pushed sea water into some ephemeral freshwater ponds used for breeding by the federally threatened frosted flatwoods salamander (Ambystoma cingulatum). After the storm, specific conductance across all ponds measured varied from 80 to 23,100 µS/cm, compared to 75 to 445 µS/cm in spring 2018. For 17 overwashed wetlands that were measured in both spring and fall 2018, posthurricane conductance observations were, on average, more than 90 times higher than in the previous spring, setting the stage for varying population responses across this coastal landscape. Importantly, we found live individual flatwoods salamanders at both overwashed and non‐overwashed sites, although we cannot yet assess the demographic consequences of this storm. We outline actions that could be incorporated into climate adaptation strategies and recovery planning for imperiled species, like A. cingulatum, that are associated with freshwater coastal wetlands in hurricane‐prone regions.
Drone‐based photogrammetry‐derived crown metrics for predicting tree and oil palm water use
Authors: Ahongshangbam Joyson , Khokthong Watit , Ellsäßer Florian , Hendrayanto Hendrayanto , Hölscher Dirk , Röll Alexander 
Published: May 2019

AbstractTranspiration at the stand level is often estimated from water use measurements on a limited number of plants and then scaled up by predicting the remaining plants of a stand by plant size‐related variables. Today, drone‐based methods offer new opportunities for plant size assessments. We tested crown variables derived from drone‐based photogrammetry for predicting and scaling plant water use. In an oil palm agroforest and an oil palm monoculture plantation in lowland Sumatra, Indonesia, tree and oil palm water use rates were measured by sap flux techniques. Simultaneously, aerial images were taken from an octocopter equipped with an Red Green Blue (RGB) camera. We used the structure from motion approach to compute several crown variables such as crown length, width, and volume. Crown volumes for both palms (69%) and trees (81%) explained much of the observed spatial variability in water use; however, the specific crown volume model differed between palms and trees and there was no single linear model fitting for both. Among the trees, crown volume explained more of the observed variability than stem diameter, and in consequence, uncertainties in stand level estimates resulting from scaling were largely reduced. For oil palms, an appropriate whole‐plant size‐related predictor variable was thus far not available. Stand level transpiration estimates in the studied oil palm agroforest were lower than those in the oil palm monoculture, which is probably due to the small‐statured trees. In conclusion, we consider drone‐derived crown metrics very useful for the scaling from single plant water use to stand‐level transpiration.
31° South: Dietary niche of an arid‐zone endemic passerine
Authors: Ribeiro Ângela M. , Smit Ben , Gilbert M. Thomas P. 
Published: May 2019

AbstractBalancing energy budgets are thought to be challenging for birds living in arid ecosystems because food supplies are low and unpredictable, and climatic conditions extreme. Thus, to ensure they obtain sufficient energy to fuel daily energetic budgets, birds may need to adjust their diets and become less selective (generalist) as conditions become harsher. To test this hypothesis, we used DNA metabarcoding to characterize both the prey availability (from pitfall traps) and the dietary content (from fecal samples) of several conspecific populations of a semi‐ and arid‐endemic insectivorous bird, the Karoo scrub‐robin (Cercotrichas coryphaeus) across a climatic gradient. Our results showed that Coleoptera, Hymenoptera, Orthoptera, and Lepidoptera were the main prey. When accounting for their presence as available prey, Coleoptera and Hymenoptera were preferred in all regions, whereas robins avoided Orthoptera and Lepidoptera in all but the most arid region. Although the different populations live in regions that vary with regards to productivity and thermoregulatory demands, we found that the dietary niche breadth (Bs) of the three populations was intermediate to low, and did not differ significantly. As a whole, our findings show that regardless of environmental harshness these insectivores have similar dietary niches, suggesting that large dietary plasticity is fundamental for their survival in energy‐depauperated ecosystems.
The puzzle of spontaneous alternation and inhibition of return: How they might fit together
Authors: Phillmore Leslie S. , Klein Raymond M. 
Published: June 2019

AbstractTwo isolated spatial phenomena share a similar “been there; done that” effect on spatial behavior. Originally discovered in rodent learning experiments, spontaneous alternation is a tendency for the organism to visit a different arm in a T‐maze on subsequent trials. Originally discovered in human studies of attention, inhibition of return is a tendency for the organism to orient away from a previously attended location. Whereas spontaneous alternation was identified by O'Keefe & Nadel as dependent on an intact hippocampus, inhibition of return is dependent on neural structures that participate in oculomotor control (the superior colliculus, parietal and frontal cortex). Despite the isolated literatures, each phenomenon has been assumed to reflect a basic novelty‐seeking process, avoiding places previously visited or locations attended. In this commentary, we explore and compare the behavioral manifestations and neural underpinnings of these two phenomena, and suggest what is still needed to determine whether they operate in parallel or serial.
Sleep patterns and the risk of adverse birth outcomes among Chinese women
Authors: Liu Bingqing , Song Lulu , Zhang Lina , Wang Lulin , Wu Mingyang , Xu Shunqing , Wang Youjie 
Published: June 2019

AbstractObjectiveTo evaluate the association between sleep patterns (sleep duration or timing) in late pregnancy and adverse birth outcomes (preterm delivery or small for gestational age, SGA).MethodsAn analysis of data from a prospective cohort study of pregnant women in Wuhan city, Hubei Province, China, between 2012 and 2014. Preterm delivery was defined as delivery before 37 gestational weeks. SGA was defined as neonatal birthweight below the 10th percentile of the predicted birthweight distribution.ResultsIn total, 11 192 women were included in the analysis. After adjustment for potential confounders, 9.1–10 hours of nocturnal sleep was associated with a lower likelihood of SGA (odds ratio [OR], 0.81; 95% confidence interval [CI], 0.66–0.99) as compared with 7.1–9 hours. As compared with intermediate mid‐sleep time (between 02:46 and 04:00), early mid‐sleep time (at or earlier than 02:45) was associated with a higher likelihood of preterm delivery (OR, 1.64; 95% CI, 1.28–2.10).ConclusionAmong a large cohort of pregnant Chinese women, 9.1–10 hours of nocturnal sleep was associated with a lower risk of SGA, whereas early mid‐sleep time was associated with a higher risk of preterm delivery.
Urothelial carcinoma of the urinary bladder related to a migrated mesh after inguinal hernioplasty: A case report
Authors: Sasaki Yutaro , Shiozaki Keito , Nakanishi Ryoichi , Izaki Hirofumi , Kanda Kazuya 
Published: June 2019

IntroductionMesh migration into the urinary bladder following repair of inguinal hernia and bladder cancer caused by a foreign body are extremely rare. We hereby report a rare case of urothelial carcinoma of the bladder related to a migrated mesh following inguinal hernioplasty.Case presentationA 70‐year‐old Japanese woman who underwent surgery for left inguinal hernia 5 years previously presented with gross hematuria. Cystoscopy and computed tomography revealed stone formed in the mesh migrated into the urinary bladder. Mesh removal surgery and partial cystectomy were performed; and pathological findings revealed muscle invasive bladder cancer. Neoadjuvant chemotherapy and radical cystectomy were performed. The pathological diagnosis was high‐grade urothelial carcinoma, stage pT3a with positive lymph nodes, stage pN3. To date, 3 months after surgery, the patient has received adjuvant chemotherapy.ConclusionTo our knowledge, this is the first report of urothelial carcinoma related to a migrated mesh after inguinal hernioplasty.
Pnictogen‐containing iron and chromium carbonyl complexes: From complexes to semiconducting frameworks
Authors: Shieh Minghuey , Li Yu‐Huei 
Published: May 2019

AbstractRecently, main group elements containing transition metal carbonyl complexes have received much attention due to their novel bonding modes and versatile reactivities. In this article, we will focus on the development of pnictogen (Bi, Sb, and As)‐containing Fe or Cr carbonyl complexes reported in our previous study, in which their rational synthetic methodologies, intriguing reactivities, as well as their special properties will be described and systematically compared. Importantly, a unique zig‐zag Bi‐Fe polymer was synthesized, and several Bi‐Cr complexes were found to exhibit surprising semiconducting behaviors with varied ultra‐low energy gaps via the through‐bond or through‐space electron communication.
The efficient biodegradation of dimethyl phthalate using an anaerobic bioelectrochemical system
Authors: Zhou Yue , Shi Chenyi , Fan Mengjie , Feng Yangyang , Xu Yuan , Chen Yingwen 
Published: May 2019

AbstractBACKGROUNDDimethyl phthalate (DMP) is refractory, persistent and easy to enrich in anaerobic environments. The urgent need to degrade this refractory organic matter with high efficiency can be met by bioelectrochemical technology. In this paper, the degradation characteristics of DMP under different reaction conditions in bioelectrical reactors (BERs) were studied.RESULTSWith operation conditions of 400 mg L−1 DMP, 1.3 V applied voltage and 50 h HRT, the highest removal efficiency of DMP was obtained in a BER (84.0%), which was higher than a conventional anaerobic system (Ana) (68.0%). Phthalic acid, heptanedioic acid and other low molecular weight products of DMP were detected in the BER, which shows that the applied voltage can stimulate the intermediate products of DMP into further degradation. Simultaneously, the abundance of microorganisms in the BER was richer than in the Ana.CONCLUSIONThe higher removal efficiency of DMP, the further degradation of DMP and the richer abundance of bacteria in the BER indicate that electrochemical methods can promote the intensive removal of DMP. © 2019 Society of Chemical Industry