bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hookah is the enemy of health campaign: a campaign for prevention of hookah smoking among youth
Authors: Sadeghi Reza , Mazloomy Mahmoodabad Seyed Saeed , Fallahzadeh Hossein , Rezaeian Mohsen , Bidaki Reza , Khanjani Narges 
Published: October 2019

AbstractHookah smoking is now a serious health threat especially for adolescents. Implementation of planned interventions can help reduce hookah smoking. This study was conducted to investigate the effect of a campaign Hookah is the Enemy of Health Campaign (HEHC) based on the protection motivation theory to prevent hookah smoking among the youth in Sirjan city, in 2018. This was a pre- and post-intervention study. Participants were 280 male and female youth who were selected randomly through the health centers of Sirjan. The educational campaign was conducted during 3 months and participants were trained through interpersonal, group, organizational and community channels and mass media. Data were collected by filling out a questionnaire (containing 64 questions) by the participant before the intervention and 3 months after. Data were analyzed by descriptive statistics (frequency and percentage), chi-square and Wilcoxon signed-rank test by SPSS20 software. The prevalence of hookah smoking was 44.3% in the target group. There was a significant change in the mean scores of knowledge and perceived susceptibility, perceived severity, response efficiency, self-efficacy, rewards, fear and protection motivation after the HEHC (p &lt; 0.05), but there was no significant difference in the structure of perceived cost (p &gt; 0.05). Also, the prevalence of hookah smoking among the target group for those who had ever consumed decreased from 8.9 to 4% and for those who used it occasionally decreased from 35 to 19.4%. The HEHC was effective in reducing hookah smoking, raising knowledge and improving the constructs of the protection motivation theory among the youth of Sirjan.
Why staff at European schools abstain from enforcing smoke-free policies on persistent violators
Authors: Schreuders Michael , Linnansaari Anu , Lindfors Pirjo , van den Putte Bas , Kunst Anton E 
Published: October 2019

Abstract
Secondary schools in European countries increasingly implement comprehensive smoke-free school policies (SFSPs) that prohibit most or even all adolescents from smoking during school hours. Consistent enforcement of SFSPs is essential for realizing optimum effectiveness. A main challenge represents adolescents who persistently violate the rules. We studied how staff in European countries respond to these persistent violators and why they may turn a blind eye. We used interview transcripts from 69 staff members at 22 schools in 6 European countries to identify cases in which staff turned a blind eye. We then applied thematic analysis for identifying the considerations as to why they turn a blind eye. Turning a blind eye on persistent violators happened among school staff in all six countries. Three considerations were identified. First, staff believe their primary role and duty is to support all adolescents to develop into well-functioning adults, and sometimes it is best to accept smoking. Second, staff expect that applying stricter disciplinary measures will not stop persistent violators and is more likely to create more severe problems. Third, staff do not feel supported by relevant actors in society (e.g. parents) in influencing adolescent smoking. We conclude that staff’s considerations stress the need to support school staff in enforcing the increasingly comprehensive rules on the most persistent smokers.
Elmod3 knockout leads to progressive hearing loss and abnormalities in cochlear hair cell stereocilia
Authors: Li Wu , Feng Yong , Chen Anhai , Li Taoxi , Huang Sida , Liu Jing , Liu Xianlin , Liu Yalan , Gao Jiangang , Yan Denise , Sun Jie , Mei Lingyun , Liu Xuezhong , Ling Jie 
Published: October 2019

Abstract
ELMOD3, an ARL2 GTPase-activating protein, is implicated in causing hearing impairment in humans. However, the specific role of ELMOD3 in auditory function is still far from being elucidated. In the present study, we used the CRISPR/Cas9 technology to establish an Elmod3 knockout mice line in the C57BL/6 background (hereinafter referred to as Elmod3−/− mice) and investigated the role of Elmod3 in the cochlea and auditory function. Elmod3−/− mice started to exhibit hearing loss from 2 months of age, and the deafness progressed with aging, while the vestibular function of Elmod3−/− mice was normal. We also observed that Elmod3−/− mice showed thinning and receding hair cells in the organ of Corti and much lower expression of F-actin cytoskeleton in the cochlea compared with wild-type mice. The deafness associated with the mutation may be caused by cochlear hair cells dysfunction, which manifests with shortening and fusion of inner hair cells stereocilia and progressive degeneration of outer hair cells stereocilia. Our finding associates Elmod3 deficiencies with stereocilia dysmorphologies and reveals that they might play roles in the actin cytoskeleton dynamics in cochlear hair cells, and thus relate to hearing impairment.
A genome-wide association study implicates multiple mechanisms influencing raised urinary albumin–creatinine ratio
Authors: Casanova Francesco , Tyrrell Jessica , Beaumont Robin N , Ji Yingjie , Jones Samuel E , Hattersley Andrew T , Weedon Michael N , Murray Anna , Shore Angela C , Frayling Timothy M , Wood Andrew R 
Published: October 2019

Abstract
Raised albumin–creatinine ratio (ACR) is an indicator of microvascular damage and renal disease. We aimed to identify genetic variants associated with raised ACR and study the implications of carrying multiple ACR-raising alleles with metabolic and vascular-related disease. We performed a genome-wide association study of ACR using 437 027 individuals from the UK Biobank in the discovery phase, 54 527 more than previous studies, and followed up our findings in independent studies. We identified 62 independent associations with ACR across 56 loci (P &lt; 5 × 10–8), of which 20 were not previously reported. Pathway analyses and the identification of 20 of the 62 variants (at r2 &gt; 0.8) coinciding with signals for at least 16 related metabolic and vascular traits, suggested multiple pathways leading to raised ACR levels. After excluding variants at the CUBN locus, known to alter ACR via effects on renal absorption, an ACR genetic risk score was associated with a higher risk of hypertension, and less strongly, type 2 diabetes and stroke. For some rare genotype combinations at the CUBN locus, most individuals had ACR levels above the microalbuminuria clinical threshold. Contrary to our hypothesis, individuals carrying more CUBN ACR-raising alleles, and above the clinical threshold, had a higher frequency of vascular disease. The CUBN allele effects on ACR were twice as strong in people with diabetes—a result robust to an optimization-algorithm approach to simulating interactions, validating previously reported gene–diabetes interactions (P ≤ 4 × 10–5). In conclusion, a variety of genetic mechanisms and traits contribute to variation in ACR.
When Polls Disagree: How Competitive Results and Methodological Quality Shape Partisan Perceptions of Polls and Electoral Predictions
Authors: Kuru Ozan , Pasek Josh , Traugott Michael W 
Published: October 2019

AbstractThis study leverages a survey experiment in the lead up to the 2016 U.S. presidential election to evaluate how partisan biases, poll results, and their methodological quality interact to shape people’s assessments of polling accuracy and electoral expectations. In a nationally representative sample, we find that individuals disproportionately find polls more credible when their preferred candidate is leading. Partisan biases are mitigated when the polls themselves vary in objective indicators of quality: while more educated respondents are more likely to identify high-quality polls accurately, low education respondents’ bias was reduced when they encountered polls with varying methodological quality. Finally, these moderators influence respondents’ electoral expectations as well. We discuss the implications for journalistic coverage of polls, public opinion, and political polarization.
The Influence of Behavioral, Social, and Environmental Factors on Reproducibility and Replicability in Aquatic Animal Models
Authors: Lieggi Christine , Kalueff Allan V , Lawrence Christian , Collymore Chereen 
Published: October 2019

AbstractThe publication of reproducible, replicable, and translatable data in studies utilizing animal models is a scientific, practical, and ethical necessity. This requires careful planning and execution of experiments and accurate reporting of results. Recognition that numerous developmental, environmental, and test-related factors can affect experimental outcomes is essential for a quality study design. Factors commonly considered when designing studies utilizing aquatic animal species include strain, sex, or age of the animal; water quality; temperature; and acoustic and light conditions. However, in the aquatic environment, it is equally important to consider normal species behavior, group dynamics, stocking density, and environmental complexity, including tank design and structural enrichment. Here, we will outline normal species and social behavior of 2 commonly used aquatic species: zebrafish (Danio rerio) and Xenopus (X. laevis and X. tropicalis). We also provide examples as to how these behaviors and the complexity of the tank environment can influence research results and provide general recommendations to assist with improvement of reproducibility and replicability, particularly as it pertains to behavior and environmental complexity, when utilizing these popular aquatic models.
Randomized, Blinded, Dose-Ranging Trial of an Ebola Virus Glycoprotein Nanoparticle Vaccine With Matrix-M Adjuvant in Healthy Adults
Authors: Fries Louis , Cho Iksung , Krähling Verena , Fehling Sarah K , Strecker Thomas , Becker Stephan , Hooper Jay W , Kwilas Steven A , Agrawal Sapeckshita , Wen Judy , Lewis Maggie , Fix Amy , Thomas Nigel , Flyer David , Smith Gale , Glenn Gregory 
Published: October 2019

Abstract

Background
Ebola virus (EBOV) epidemics pose a major public health risk. There currently is no licensed human vaccine against EBOV. The safety and immunogenicity of a recombinant EBOV glycoprotein (GP) nanoparticle vaccine formulated with or without Matrix-M adjuvant were evaluated to support vaccine development.

Methods
A phase 1, placebo-controlled, dose-escalation trial was conducted in 230 healthy adults to evaluate 4 EBOV GP antigen doses as single- or 2-dose regimens with or without adjuvant. Safety and immunogenicity were assessed through 1-year postdosing.

Results
All EBOV GP vaccine formulations were well tolerated. Receipt of 2 doses of EBOV GP with adjuvant showed a rapid increase in anti-EBOV GP immunoglobulin G titers with peak titers observed on Day 35 representing 498- to 754-fold increases from baseline; no evidence of an antigen dose response was observed. Serum EBOV-neutralizing and binding antibodies using wild-type Zaire EBOV (ZEBOV) or pseudovirion assays were 3- to 9-fold higher among recipients of 2-dose EBOV GP with adjuvant, compared with placebo on Day 35, which persisted through 1 year.

Conclusions
Ebola virus GP vaccine with Matrix-M adjuvant is well tolerated and elicits a robust and persistent immune response. These data suggest that further development of this candidate vaccine for prevention of EBOV disease is warranted.
The growing nostalgia for past regulatory misadventures and the risk of repeating these mistakes with Big Tech
Authors: Wilson Christine S , Klovers Keith 
Published: October 2019

Abstract
Digital markets are increasingly described as the ‘railroads’ of the 21st century. Extending that metaphor, some commentators argue we should revive stale railroad-era economic regulations and adapt them to the digital age. This enthusiasm appears to be buoyed by both a sudden nostalgia for railroad and airline regulations once administered by the Interstate Commerce Commission (ICC) and the Civil Aeronautics Board (CAB) and an equally sudden amnesia of the enormous harm those regulations caused to consumers. ICC and CAB regulations are indeed an apt metaphor, as they illustrate perfectly how sectoral regulations sold to the public as simple, clear, and cheap can go awry. Ultimately, a bipartisan consensus emerged to disband those agencies and deregulate those industries. After deregulation, prices fell, output expanded, and firms innovated. Proposals to regulate Big Tech today in a similar fashion forget these important lessons. We should know better than to do the same thing again today and expect a different result.
Trickle-Round Signals: When Low Status Is Mixed with High
Authors: Bellezza Silvia , Berger Jonah 
Published: October 2019

AbstractTrickle-down theories suggest that status symbols and fashion trends originate from the elites and move downward, but some high-end restaurants serve lowbrow food (e.g., potato chips, macaroni and cheese), and some high-status individuals wear downscale clothing (e.g., ripped jeans, duct-taped shoes). Why would high-status actors adopt items traditionally associated with low-status groups? Using a signaling perspective to explain this phenomenon, the authors suggest that elites sometimes adopt items associated with low-status groups as a costly signal to distinguish themselves from middle-status individuals. As a result, signals sometimes trickle round, moving directly from the lower to the upper class, before diffusing to the middle class. Furthermore, consistent with a signaling perspective, the presence of multiple signaling dimensions facilitates this effect, enabling the highs to mix and match high and low signals and differentiate themselves. These findings deepen the understanding of signaling dynamics, support a trickle-round theory of fashion, and shed light on alternative status symbols.
Prognosis viewing for nasopharyngeal carcinoma treated with intensity-modulated radiation therapy: application of nomogram and decision curve analysis
Authors: Fei Zhaodong , Qiu Xiufang , Li Mengying , Chen Chuanben , Li Yi , Huang Yingying 
Published: October 2019

Abstract

Objective
To view and evaluate the prognosis factors in patients with nasopharyngeal carcinoma (NPC) treated with intensity modulated radiation therapy using nomogram and decision curve analysis (DCA).

Methods
Based on a primary cohort comprising consecutive patients with newly confirmed NPC (n = 1140) treated between January 2014 and December 2015, we identified independent prognostic factors of overall survival (OS) to establish a nomogram. The model was assessed by bootstrap internal validation and external validation in an independent validation cohort of 460 patients treated between January 2013 and December 2013. The predictive accuracy and discriminative ability were measured by calibration curve, concordance index (C-index) and risk-group stratification. The clinical usefulness was assessed by DCA.

Results
The nomogram incorporated T-stage, N-stage, age, concurrent chemotherapy and primary tumour volume (PTV). The calibration curve presented good agreement for between the nomogram-predicted OS and the actual measured survival probability in both the primary and validation cohorts. The model showed good discrimination with a C-index of 0.741 in the primary cohort and 0.762 in the validation cohort. The survival curves of different risk-groups were separated clearly. Decision curve analysis demonstrated that the nomogram provided a higher net benefit (NB) across a wider reasonable range of threshold probabilities for predicting OS.

Conclusion
This study presents a predictive nomogram model with accurate prediction and independent discrimination ability compared with combination of T-stage and N-stage. The results of DCA supported the point that PTV can help improve the prognostic ability of T-stage and should be added to the TNM staging system.
Application of focused ion-beam sampling for sidewall-roughness measurement of free-standing sub-μm objects by atomic force microscopy
Authors: Nagatomi Takaharu , Nakao Tatsuya , Fujimoto Yoko 
Published: October 2019

Abstract
In the present study, a free-standing object-sampling technique for microelectromechanical systems (MEMS) is developed to measure their sidewall surface roughnesses by atomic force microscopy (AFM). For this purpose, a conventional focused ion beam (FIB) sampling technique widely used for cross-sectional transmission electron microscope specimen preparation was applied. The sub-nm-order roughness parameters were quantitatively measured for sidewalls of Si-bridge test samples. The roughness parameters were compared before and after H2 annealing treatment, which induced smoothing of the surface by migration of the Si atoms. The reduction in the surface roughness by a factor of approximately one-third with 60-s H2 annealing was quantitatively evaluated by AFM. The present study confirms that the developed FIB–AFM technique is one potential approach for quantitatively evaluating the surface-roughness parameters on the oblique faces of free-standing objects in MEMS devices.
Modelling the post-reionization neutral hydrogen (H i) 21-cm bispectrum
Authors: Sarkar Debanjan , Majumdar Suman , Bharadwaj Somnath 
Published: October 2019

ABSTRACT
Measurements of the post-reionization 21-cm bispectrum $B_{{\rm H\,{\small I}}\, }(\boldsymbol {k_1},\boldsymbol {k_2},\boldsymbol {k_3})$ using various upcoming intensity mapping experiments hold the potential for determining the cosmological parameters at a high level of precision. In this paper, we have estimated the 21-cm bispectrum in the z range 1 ≤ z ≤ 6 using seminumerical simulations of the neutral hydrogen (H i) distribution. We determine the k and z range where the 21-cm bispectrum can be adequately modelled using the predictions of second-order perturbation theory, and we use this to predict the redshift evolution of the linear and quadratic H i bias parameters b1 and b2, respectively. The b1 values are found to decrease nearly linearly with decreasing z, and are in good agreement with earlier predictions obtained by modelling the 21-cm power spectrum $P_{{\rm H\,{\small I}}\, }(k)$. The b2 values fall sharply with decreasing z, becomes zero at z ∼ 3 and attains a nearly constant value b2 ≈ −0.36 at z < 2. We provide polynomial fitting formulas for b1 and b2 as functions of z. The modelling presented here is expected to be useful in future efforts to determine cosmological parameters and constrain primordial non-Gaussianity using the 21-cm bispectrum.
Beyond second-order convergence in simulations of magnetized binary neutron stars with realistic microphysics
Authors: Most E R , Papenfort L Jens , Rezzolla L 
Published: October 2019

ABSTRACT
We investigate the impact of using high-order numerical methods to study the merger of magnetized neutron stars with finite-temperature microphysics and neutrino cooling in full general relativity. By implementing a fourth-order accurate conservative finite-difference scheme we model the inspiral together with the early post-merger and highlight the differences to traditional second-order approaches at the various stages of the simulation. We find that even for finite-temperature equations of state, convergence orders higher than second order can be achieved in the inspiral and post-merger for the gravitational-wave phase. We further demonstrate that the second-order scheme overestimates the amount of proton-rich shock-heated ejecta, which can have an impact on the modelling of the dynamical part of the kilonova emission. Finally, we show that already at low resolution the growth rate of the magnetic energy is consistently resolved by using a fourth-order scheme.
Common envelope to explosion delay time of Type Ia supernovae
Authors: Soker Noam 
Published: October 2019

ABSTRACT
I study the rate of Type Ia supernovae (SNe Ia) within about a million years after the assumed common envelope evolution (CEE) that forms the progenitors of these SNe Ia, and find that the population of SNe Ia with short CEE to explosion delay (CEED) time is ≈few × 0.1 of all SNe Ia. I also claim for an expression for the rate of these SNe Ia that occur at short times after the CEE ($t_{\rm CEED} \lesssim 10^6 {~\rm yr}$), which is different from that of the delay time distribution (DTD) billions of years after star formation. This tentatively hints that the physical processes that determine the short CEED time distribution (CEEDTD) are different (at least to some extent) from those that determine the DTD at billions of years. To reach these conclusions I examine SNe Ia that interact with a circumstellar matter (CSM) within months after explosion, so-called SNe Ia-CSM, and the rate of SNe Ia that on a time-scale of tens to hundreds of years interact with a CSM that might have been a planetary nebula, so-called SNe Ia inside a planetary nebula (SNIPs). I assume that the CSM in these populations results from a CEE, and hence this study is relevant mainly to the core-degenerate (CD) scenario, the double-degenerate (DD) scenario, the double-detonation (DDet) scenario with white dwarf companions, and to the CEE-wind channel of the single-degenerate (SD) scenario.
A DECam view of the diffuse dwarf galaxy Crater II: the colour–magnitude diagram
Authors: Walker A R , Martínez-Vázquez C E , Monelli M , Vivas A K , Bono G , Gallart C , Cassisi S , Andreuzzi G , Bernard E J , Dall’Ora M , Fiorentino G , Nidever D L , Olsen K , Pietrinferni A , Stetson P B 
Published: October 2019

ABSTRACT
We present a deep Blanco/DECam colour–magnitude diagram (CMD) for the large but very diffuse Milky Way satellite dwarf galaxy Crater II. The CMD shows only old stars with a clearly bifurcated subgiant branch (SGB) that feeds a narrow red giant branch. The horizontal branch (HB) shows many RR Lyrae and red HB stars. Comparing the CMD with [Fe/H] = −2.0 and [α/Fe] = + 0.3 alpha-enhanced BaSTI isochrones indicates a mean age of 12.5 Gyr for the main event and a mean age of 10.5 Gyr for the brighter SGB. With such multiple star formation events Crater II shows similarity to more massive dwarfs that have intermediate age populations, however for Crater II there was early quenching of the star formation and no intermediate age or younger stars are present. The spatial distribution of Crater II stars overall is elliptical in the plane of the sky, the detailed distribution shows a lack of strong central concentration, and some inhomogeneities. The 10.5 Gyr subgiant and upper main-sequence stars show a slightly higher central concentration when compared to the 12.5 Gyr population. Matching to Gaia DR2 we find the proper motion of Crater II: μαcos δ = −0.14 ± 0.07, μδ = −0.10 ± 0.04 mas yr−1, approximately perpendicular to the semimajor axis of Crater II. Our results provide constraints on the star formation and chemical enrichment history of Crater II, but cannot definitively determine whether or not substantial mass has been lost over its lifetime.