bluuebunny/crossref_metadata_2025_split huggingface dataset:
Model and robust gain‐scheduled PID control of a bio‐inspired morphing UAV based on LPV method
Authors: Shao Pengyuan , Wu Jin , Wu Chengfu , Ma Songhui 
Published: October 2019

AbstractIn this paper, a linear parameter‐varying (LPV)‐based model and robust gain‐scheduled structural proportion integral and derivative (PID) control design solution are proposed and applied on a bio‐inspired morphing wing unmanned aerial vehicle (UAV) for the morphing process. In the LPV model method, the authors propose an improved modeling method for LPV systems. The method combines partial linearization and function substitution. Using the proposed method, we can choose the varying parameters simply, thus creating a model that is more flexible and applicable. Then, a robust gain‐scheduled structural PID control design method is given by introducing a structural matrix to design a structural PID controller, which is more consistent with the structure of the PID controller used in practice and has a simpler structure than representative ones in the existing literature. The simulation results show that the developed LPV morphing UAV model is able to catch the response of the original nonlinear model with a smaller error than the existing Jacobian linearization method and the designed controller can maintain stable flights in practice with satisfactory robustness and performance.
Analysis of predicted amino acid biosynthesis in Rv3344c in Mycobacterium tuberculosis H37Rv using bioinformatics tools
Authors: Joshi Khyati , Meena Swati , Meena Laxman S. 
Published: October 2019

AbstractAccording to World Health Organization (WHO) report, Mycobacterium tuberculosis H37Rv (M. tuberculosis) affects one‐third population of the world. Emergence of effective treatment/research against this disease is need of the hour. Therefore, we present some important aspects of Rv3344c, which is a PE_PGRS protein. Evidence shows that PE_PGRS proteins show fibronectin binding activity. This protein has affinity for calcium and also shows motifs of GTP‐binding protein. It also shows the presence of sites for ribose‐5‐phosphate binding and motifs of aspartate‐beta‐semialdehyde dehydrogenase, both of which are involved in amino acid biosynthesis. Thus, this protein might be targeted to block the amino acid biosynthesis in M. tuberculosis. This article takes into consideration some important aspects of Rv3344c protein as its function is still unknown. This study includes retrieval of protein sequence database, multiple sequence alignment, protein–protein interaction, epitope prediction, localization, function prediction, phosphorylation site prediction, model building and its validation, ligand‐binding prediction along with mutational analysis. Hence, this study might be an important step in the development of new drugs and treatment of tuberculosis.
Biotransformation of cladribine using a stabilized biocatalyst in calcium alginate beads
Authors: Lapponi María J. , Britos Claudia N. , Rivero Cintia W. , Trelles Jorge A. 
Published: October 2019

AbstractCladribine is a nucleoside analogue widely used in the pharmaceutical industry for the treatment of several neoplasms, including hairy‐cell leukemia among others. This compound has also shown efficacy in the treatment of autoimmune diseases such as rheumatoid arthritis and multiple sclerosis. In this work, a green bioprocess for cladribine biosynthesis using immobilized Arthrobacter oxydans was developed. The microorganism was stabilized by entrapment immobilization in the natural matrix alginate. Different reaction parameters were optimized obtaining a biocatalyst able to achieve cladribine bioconversion values close to 85% after 1 hr, the shortest reaction times reported so far. The developed bioprocess was successfully scaled‐up reaching a productivity of 138 mg L−1 hr−1. Also, the biocatalyst was stable for 5 months in storage and in 96 hr at operational conditions.
Treatment patterns, adverse events, healthcare resource use and costs among commercially insured patients with mantle cell lymphoma in the United States
Authors: Kabadi Shaum M. , Near Aimee , Wada Keiko , Burudpakdee Chakkarin 
Published: October 2019

AbstractIntroductionThere are limited data on treatment patterns, adverse events (AEs), and economic burden in younger, commercially insured patients treated for mantle cell lymphoma (MCL).MethodsAdults with ≥1 treatment for MCL between 1 November 2013‐31 December 2017 were identified from IQVIA Real‐World Data Adjudicated Claims‐US; index date was first treatment. Patients carried ≥1 MCL diagnosis, were newly treated, and were enrolled continuously for ≥12 months prior to and ≥30 days following index. Patients receiving the four most common MCL regimens were included. Measures included frequency of incident AEs, resource use, and costs overall and by number of AEs. Adjusted logistic regression and generalized linear modeling evaluated risk of hospitalization and all‐cause costs per patient per month (PPPM).ResultsTwo thousand five hundred and nine treated patients had a drug‐specific code and were classified to a specific treatment regimen. Of those patients, 1785 patients received at least one of the four most commonly used MCL regimens (R‐CHOP, rituximab monotherapy, B‐R, and ibrutinib) at some point over follow‐up (median 23 months). R‐CHOP was the most common regimen observed in the first line (26%), followed by rituximab monotherapy (19%), B‐R (15%), and ibrutinib (5%). The median age was 57 years; median Charlson Comorbidity Index was 0. Among patients receiving the four most common regimens, 63% of patients experienced ≥1 incident AE (R‐CHOP 77%, B‐R 58%, and ibrutinib 52%). An increasing number of incident AEs was associated with increased hospitalization risk (odds ratio = 2.4; 95% Confidence Interval [CI] 2.1‐2.7) and increased mean costs PPPM (cost ratio = 1.1; 95% CI 1.1‐1.2).DiscussionThis is the largest study describing treatment patterns and clinical and economic impact of MCL treatment. The most common regimens were R‐CHOP, rituximab monotherapy, B‐R, and ibrutinib. The majority of treated patients experienced at least one incident AE, with hospitalization risk and all‐cause costs increasing as the number of AEs increased.
The polymorphisms (rs3213801 and rs5744533) of DNA polymerase kappa gene are not related with glioma risk and prognosis: A case‐control study
Authors: Wu Ying , Zhou Linghui , Deng Yujiao , Li Na , Yang Pengtao , Dong Shanshan , Yang Si , Zheng Yi , Yao Li , Zhang Ming , Zhai Zhen , Dai Zhijun , Wu Yuan 
Published: October 2019

AbstractDNA polymerase kappa (POLK), one of the specialized Y family DNA polymerases, functions in translesion synthesis and is suggested to be related with cancers. Single nucleotide polymorphisms (SNPs) in specialized DNA polymerases have been demonstrated to be associated with cancer risk. To evaluate the association of two common POLK variants (rs3213801 C>T and rs5744533 C>T) with glioma, we conducted a case‐control study and genotyped these two POLK variants in 605 patients and 1300 healthy controls. The association analysis revealed no significant correlations were observed between these two POLK SNPs and glioma risk. However, the POLK rs3213801 CT genotype was found to be higher in older glioma patients (≥40) than in younger patients (P = .026). Compared with patients harboring the CC genotype, the frequencies of POLK rs5744533 CT and CT+TT genotypes were increased in patients with lower World Health Organization (WHO) grade glioma (P = .028, 0.044, respectively). According to Kaplan‐Meier analysis and log‐rank tests, POLK SNPs were not correlated with either the overall survival or progression‐free survival. Nevertheless, multivariate analysis revealed that the age (≥40) could increase the risk of death in glioma patients (P < .05), while gross‐total resection and temozolomide treatment were found to play protective roles in glioma prognosis (P < .001, respectively). Overall, our results indicated that POLK variants rs3213801 and rs5744533 are not associated with glioma risk and prognosis. However, these polymorphisms are likely to be associated with certain glioma characteristics, such as age and WHO grade. The age, surgery types, and chemotherapy could be independent prognostic factors in glioma. More studies are required to confirm our findings.
Percutaneous embolization of lymphatic fistulae as treatment for protein‐losing enteropathy and plastic bronchitis in patients with failing Fontan circulation
Authors: Maleux Geert , Storme Emma , Cools Bjorn , Heying Ruth , Boshoff Derize , Louw Jacoba J. , Frerich Stefan , Malekzadeh‐Milanii Sofie , Hubrechts Jelena , Brown Stephen C. , Gewillig Marc 
Published: October 2019

AbstractBackgroundTo determine the feasibility and clinical result of selective embolization of hepatoduodenal or paratracheal lymphatics in Fontan patients with protein‐losing enteropathy (PLE) or plastic bronchitis (PB).MethodsDilated lymph vessels in periportal (PLE) or paratracheal (PB) position were percutaneously punctured with a 22G Chiba needle. Intralymphatic position was confirmed by water soluble contrast injection with drainage to hepatoduodenal or tracheal fistulae. After flushing with 10% glucose solution, occlusion of hepatoduodenal or paratreacheal lymphatics was effected by injection of 1–4 cc mixture 4/1 of Lipiodol/n‐butyl cyanoacrylate (n‐BCA; Histoacryl).ResultsSeven patients with proven PLE were treated with periportal lymphatic embolization 10.7 (range: 6.6–13.5) years after the Fontan operation. The Fontan operation was performed at a median age of 3.7 (range: 2.9–5.7) years and PLE started a median of 3.1 (range: 0.9–4.7) years later. Five patients required a second procedure 2–8 months later. Complications were limited (spillage of glue in portal branch, transient cholangitis, and caustic duodenal bleeding). Six of seven patients reported significant improvement in quality of life and normalization of albumin levels after limited follow‐up (p < .01). One patient (Fontan at 2.9 years; age 16.4 years) had PB for 2 years. Selective transthoracic cone‐beam‐directed puncture of left and right paratracheal lymphatics with n‐BCA embolization of distal lymphatic fistulae resulted in lasting absence of tracheal casts (11 months).ConclusionsEmbolization of periportal/peritracheal lymphatics is a promising technique in Fontan patients with PLE/PB. Larger series are required to determine incidence and reasons of success/failure, with long‐term results and effects on liver function.
Effect of Oxide Support on Catalytic Performance of FeNi‐based Catalysts for CO2‐assisted Oxidative Dehydrogenation of Ethane
Authors: Yan Binhang , Yao Siyu , Chen Jingguang G. 
Published: October 2019

AbstractCO2‐assisted oxidative dehydrogenation of ethane over Fe3Ni1 catalysts supported on SiO2, ZrO2, and CeO2, as well as CeO2‐supported Fe3xNix with different metal loadings (x=0.25, 0.5, 1, 2, 4), were investigated to illustrate the effects of the oxide support and the metal loading amount in tuning the catalytic activity and selectivity. The oxidation state and the dispersion of the Ni and Fe species on the supported catalysts were determined by using in‐situ X‐ray diffraction (XRD) and X‐ray absorption fine structure (XAFS) measurements. Among these FeNi‐based catalysts, Fe3Ni1/CeO2 exhibited the best catalytic activity and maximum ethylene yield for the oxidative dehydrogenation of ethane. Excessive loading amount of active metals changed the reaction selectivity from oxidative dehydrogenation to dry reforming. The high activity and selectivity for CO2‐assisted oxidative dehydrogenation of ethane over Fe3Ni1/CeO2 are likely due to the formation of Ni‐FeOx/CeOx interfacial sites, while the presence of Ni‐ZrO2 interfacial sites on Fe3Ni1/ZrO2 and NiFe‐CeOx interfacial sites on Fe12Ni4/CeO2 likely tune the reaction selectivity toward dry reforming of ethane.
Aromatization of Ethylene – Main Intermediate for MDA?
Authors: Vollmer Ina , Abou‐Hamad Edy , Gascon Jorge , Kapteijn Freek 
Published: October 2019

AbstractMethane dehydroaromatization (MDA) over Mo/HZSM‐5 has been hypothesized in literature to proceed via a two‐step mechanism: methane is first converted to ethylene on the molybdenum (Mo) functionality and then ethylene is oligomerized, cyclized and dehydrogenated on the Brønsted acid sites (BAS) of the HZSM‐5 support. This hypothesis is tested by studying the conversion of ethylene at the same conditions as used for MDA, namely 700 °C, atmospheric pressure, and by co‐feeding experiments with H2 and CH4. Our results suggest that ethylene is not the main intermediate for MDA, because the aromatic selectivities obtained from methane conversion are higher than selectivities measured during ethylene conversion. Furthermore, carbonaceous deposits formed during MDA have a lower density, are more hydrogenated and more active than the ones formed during ethylene aromatization (EDA). Similarly as for MDA, an activation period in which Mo carburizes to its active phase and an induction period, in which aromatics formation rates increase to their maximum are observed for ethylene conversion. The induction period, which was explained by the buildup of a hydrocarbon pool (HCP) is much faster with methane than with ethylene. This period, is attributed to a slow buildup of hydrocarbons, strongly adsorbed on Mo sites, because it is only observed with catalysts containing Mo. Hydrogen co‐feeding with ethylene leads to the formation of more reactive coke species and a significantly prolonged lifetime of the catalyst, but not to a faster buildup of the HCP.
Development of Copper Cobalt Sulfide with Cu : Co Ratio Variation on Carbon Cloth as an Efficient Electrode Material for the Oxygen Evolution Reaction
Authors: Mahala Chavi , Sharma Riya , Sharma Mamta Devi , Pande Surojit 
Published: October 2019

AbstractWhen designing a device for energy conversion, development of a highly active catalyst for OER (oxygen evolution reaction) reaction in alkaline medium is of utmost importance. For energy conversion, herein, we developed copper cobalt sulfide on carbon cloth (CC) using a simple and facile hydrothermal method. A vertically grown 2D sheet‐like structure of copper‐cobalt sulfide is observed using L‐cysteine as a sulfur source. An optimized ratio of copper(II) and cobalt(III) and the best sulfur source are found to boost the electrocatalytic activity of mixed metal thiospinel for OER. Several characterization techniques (XRD, Raman, FESEM, TEM, XPS, and ICP‐AES) were used to confirm phase purity, morphology, and composition of copper cobalt sulfides. We have established that 2D nanosheets of CuCo3Sz/CC exhibited superior electrocatalytic performance over bare RuO2 in 1.0 M KOH solution. It is observed that CuCo3Sz/CC need only 105 mV overpotential to generate 5 mA/cm2 current density. CuCo3Sz/CC is very stable and able to produce unaltered current density under an applied potential of 1.615 V vs. RHE for 48 h. Electrochemically active surface area calculation is performed for all catalysts to confirm higher electrocatalytic activity. The catalyst, CuCo3Sz/CC is used in a broad pH region using 0.5 M KOH, saline water, and 0.5 M Na2SO4 electrolyte solution to widen the applicability of water splitting. This work shows an avenue to develop active and durable electrocatalyst for OER without using any noble metal electrocatalyst.
Syntheses and Characterization of a Pair of Isomers of Heteroleptic Bis(Bidentate) Ruthenium(II) Complexes with Two Different Monodentate Ligands
Authors: Toyama Mari , Takizawa Takako , Morita Itaru , Nagao Noriharu , Kuramochi Yusuke , Ishida Hitoshi 
Published: October 2019

AbstractTwo isomers of heteroleptic bis(bidentate) ruthenium(II) complexes with dimethyl sulfoxide (dmso) and chloride ligands, trans(Cl,Nbpy)‐ and trans(Cl,NHdpa)‐[Ru(bpy)Cl(dmso‐S)(Hdpa)]+ (bpy: 2,2′‐bipyridine; Hdpa: di‐2‐pyridylamine), are synthesized. This is the first report on the selective synthesis of a pair of isomers of cis‐[Ru(L)(L′)XY]n+ (L≠L′: bidentate ligands; X≠Y: monodentate ligands). The structures of the ruthenium(II) complexes are clarified by means of X‐ray crystallography, and the signals in the 1H NMR spectra are assigned based on 1H–1H COSY spectra. The colors of the two isomers are clearly different in both the solid state and solution: the trans(Cl,Nbpy) isomer has a deep red color, whereas the trans(Cl,NHdpa) isomer is yellow. Although both complexes have intense absorption bands at λ≈440–450 nm, only the trans(Cl,Nbpy) isomer has a shoulder band at λ≈550 nm. DFT calculations indicate that the LUMOs of both isomers are the π* orbitals in the bpy ligand, and that the LUMO level of the trans(Cl,Nbpy) isomer is lower than that of the trans(Cl,NHdpa) isomer due to the trans effect of the Cl ligand; thus resulting in the appearance of the shoulder band. The HOMO levels are almost the same in both isomers. The energy levels are experimentally supported by cyclic voltammograms, in which these isomers have different reduction potentials and similar oxidation potentials.
Multiemotional product color design using gray theory and nondominated sorting genetic algorithm‐III
Authors: Ding Man , Dong Wei 
Published: October 2019

AbstractWhen users select products, they consider the emotional experience resulting from the color of the product. However, the emotional demands of users for product color are multidimensional and diverse. It is very important yet difficult to accurately grasp multiemotional image requirements and effectively convert them into design elements. Therefore, multiemotional product color design (MEPCD) has become a very important and challenging research topic. In this article, a novel MEPCD system using gray theory (GT) and nondominated sorting genetic algorithm‐III (NSGA‐III) is proposed to effectively solve the MEPCD problem. First, the image perception spaces of users, which exist in different emotional dimensions, were collected using factor analysis and the semantic differential technique. Then, GT was used to establish a multidimensional emotional product color image evaluation model. Finally, NSGA‐III was used to optimize and design a multiemotional color scheme for a product. Furthermore, according to actual conditions, an MEPCD system was established based on the proposed method. The design case study shows that the method and design system proposed in this article have a certain range of applicability and can effectively improve the practicality of MEPCD.
Highly Regioselective Methylation of Guanosine Nucleotides: An Efficient Synthesis of 7‐Methylguanosine Nucleotides
Authors: Senthilvelan Annamalai , Shanmugasundaram Muthian , Kore Anilkumar R. 
Published: October 2019

AbstractThis article describes a simple, reliable, efficient, and general method for the synthesis of 7‐methylguanosine nucleotides such as 7‐methylguanosine 5′‐O‐monophosphate (m7GMP), 7‐methylguanosine 5′‐O‐diphosphate (m7GDP), 7‐methyl‐2′‐deoxyguanosine 5′‐O‐triphosphate (m72′dGTP), and 7‐methylguanosine 5′‐O‐triphosphate (m7GTP) starting from the corresponding guanosine nucleotide is described. The present protocol involves methylation reaction of guanosine nucleotide using dimethyl sulfate as a methylating agent and water as a solvent at room temperature to provide the corresponding 7‐methylguanosine nucleotide in good yields with high purity (>99.5%). It is noteworthy that the present methylation reaction proceeds smoothly under aqueous conditions that is highly regioselective to afford exclusive 7‐methylguanosine nucleotide. © 2019 by John Wiley & Sons, Inc.Basic Protocol: Synthesis of 7‐methylguanosine nucleotides.
Flow Cytometric Analysis of Hematopoietic Populations in Rat Bone Marrow. Impact of Trauma and Hemorrhagic Shock
Authors: Francis Wendy R. , Ireland Rachel E. , Spear Abigail M. , Jenner Dominic , Watts Sarah A. , Kirkman Emrys , Pallister Ian 
Published: October 2019

AbstractSevere injury and hemorrhagic shock (HS) result in multiple changes to hematopoietic differentiation, which contribute to the development of immunosuppression and multiple organ failure (MOF). Understanding the changes that take place during the acute injury phase may help predict which patients will develop MOF and provide potential targets for therapy. Obtaining bone marrow from humans during the acute injury phase is difficult so published data are largely derived from peripheral blood samples, which infer bone marrow changes that reflect the sustained inflammatory response. This preliminary and opportunistic study investigated leucopoietic changes in rat bone marrow 6 h following traumatic injury and HS. Terminally anesthetized male Porton Wistar rats were allocated randomly to receive a sham operation (cannulation with no injury) or femoral fracture and HS. Bone marrow cells were flushed from rat femurs and immunophenotypically stained with specific antibody panels for lymphoid (CD45R, CD127, CD90, and IgM) or myeloid (CD11b, CD45, and RP‐1) lineages. Subsequently, cell populations were fluorescence‐activated cell sorted for morphological assessment. Stage‐specific cell populations were identified using a limited number of antibodies, and leucopoietic changes were determined 6 h following trauma and HS. Myeloid subpopulations could be identified by varying levels CD11b expression, CD45, and RP‐1. Trauma and HS resulted in a significant reduction in total CD11b + myeloid cells including both immature (RP‐1(−)) and mature (RP‐1+) granulocytes. Multiple B‐cell lymphoid subsets were identified. The total percentage of CD90+ subsets remained unchanged following trauma and HS, but there was a reduction in the numbers of maturing CD90(−) cells suggesting movement into the periphery. © 2019 The Authors. Cytometry Part A published by Wiley Periodicals, Inc. on behalf of International Society for Advancement of Cytometry.
Vereinfachter Nachweis von Aussteifungswänden aus unbewehrtem Mauerwerk
Authors: Graubner Carl‐Alexander , Müller Dominik 
Published: October 2019

AbstractAccording to the German National Annex to DIN EN 1996‐3, a calculative verification of the bracing system may be omitted if, besides other requirements, an obviously sufficient number of sufficiently long shear walls is in place. If it is questionable whether a building complies with this requirement, a time‐consuming verification of the bracing system according to DIN EN 1996‐1‐1/NA is unavoidable. This article therefore presents a simplified verification method for the bracing system, which will prospectively be included in the next revision of DIN EN 1996‐3. The simplified bracing verification can already be used as a decision‐making aid to omit the calculative bracing verification according to DIN EN 1996‐1‐1/NA.
Grazing disturbance promotes exotic annual grasses by degrading soil biocrust communities
Authors: Root Heather T. , Miller Jesse E. D. , Rosentreter Roger 
Published: October 2019

AbstractExotic invasive plants threaten ecosystem integrity, and their success depends on a combination of abiotic factors, disturbances, and interactions with existing communities. In dryland ecosystems, soil biocrusts (communities of lichens, bryophytes, and microorganisms) can limit favorable microsites needed for invasive species establishment, but the relative importance of biocrusts for landscape‐scale invasion patterns remains poorly understood. We examine effects of livestock grazing in habitats at high risk for invasion to test the hypothesis that disturbance indirectly favors exotic annual grasses by reducing biocrust cover. We present some of the first evidence that biocrusts increase site resistance to invasion at a landscape scale and mediate the effects of disturbance. Biocrust species richness, which is reduced by livestock grazing, also appears to promote native perennial grasses. Short mosses, as a functional group, appear to be particularly valuable for preventing invasion by exotic annual grasses. Our study suggests that maintaining biocrust communities with high cover, species richness, and cover of short mosses can increase resistance to invasion. These results highlight the potential of soil surface communities to mediate invasion dynamics and suggest promising avenues for restoration in dryland ecosystems.