bluuebunny/crossref_metadata_2025_split huggingface dataset:
Challenges in Designing Curriculum for Trans-Disciplinary Education: On Cases of Designing Concentration on Informing Science and Master Program on Data Science
Authors: Grozdanov Christozov Dimitar , Rasheva-Yordanova Katia , Toleva-Stoimenova Stefka 
Published: April 2019

Aim/Purpose: The growing complexity of the business environment and business processes as well as the Big Data phenomenon has an impact on every area of human activity nowadays. This new reality challenges the effectiveness of traditional narrowly oriented professional education. New areas of competences emerged as a synergy of multiple knowledge areas – transdisciplines. Informing Science and Data Science are just the first two such new areas we may identify as transdisciplines. Universities are facing the challenge to educate students for those new realities.

Background: The purpose of the paper is to share the authors’ experience in designing curriculum for training bachelor students in Informing Science as a concentration within an Information Brokerage major, and a master program on Data Science.

Methodology: Designing curriculum for transdisciplines requires diverse expertise obtained by both academia and industries and passed through several stages - identifying objectives, conceptualizing curriculum models, identifying content, and development pedagogical priorities.

Contribution: Sharing our experience acquired in designing transdiscipline programs will contribute to a transition from a narrow professional education towards addressing 21st-century challenges.

Findings: Analytical skills, combined with training in all categories of so-called “soft skills”, are essential in preparing students for a successful career in a transdiciplinary area of activities.

Recommendations for Practitioners: Establishing a working environment encouraging not only sharing but close cooperation is essential nowadays.

Recommendations for Researchers: There are two aspects of training professionals capable of succeeding in a transdisciplinary environment: encouraging mutual respect and developing out-of-box thinking.

Impact on Society: The transition of higher education in a way to meet current challenges.

Future Research	The next steps in this research are to collect feedback regarding the professional careers of students graduating in these two programs and to adjust the curriculum accordingly.
Pengaruh Metode Isolasi a-mangostin dari Kulit Buah Manggis (Garcinia mangostana L.) terhadap Rendemen α-mangostin
Authors: Idawati Sri , Hakim Aliefman , Andayani Yayuk 
Published: April 2019

Abstract: The purpose of this research is to know the effect of the isolation method of the yield of α-mangostin resulting from mangosteen rind. Mangosteen (Garcinia mangostana L.) is the source of xanthone secondary metabolites. Derivatives xanthone which is the main bioactive compound and becomes a major compound in the mangosteen plant, namely α-mangostin. This main compound has been isolated from ethanol extract on mangosteen rind using different extraction methods namely maceration and soxhletation. Purification was done by the recrystallization method with solvent ethanol: aquades (1:1). The Maceration extraction method produce the yields of extract and the yields of pure compounds (α-mangostin) is higher than that of soxhletation. The Maceration extraction method produces yields of extract 30,12% and yields of α-mangostin 4,27% while the soxhletation extraction method produce the yields of extract 26,34% and the yields of α-mangostin 2,13%. This yellow powder isolate has a melting point of 179,7 ºC. Purification is monitored by thin layer chromatography (TLC) and structural elucidation is carried out using FT-IR spectroscopy data. Key Words: Isolation, α-mangostin, Garcinia mangostana
Explorasi Mikroba Beraroma dari Bahan Alam
Authors: Sedijani Prapti , Rasmi Dewa Ayu Citra , Bahri Syamsul 
Published: April 2019

Abstract: The Scented volatile compound has a huge market as its wide applications in daily life. The extraction of this compound from natural resources produces a very low rendement. Microbes synthesize secondary metabolit might resemble of their host have been explored from scented natural resources (flowers: Damask rose, Jasminum sambac and Plumeria acutifolia); cymbopogon, muntinga calabura L and leave of Panadus amaryllis). It was found 12 bacterial and 14 fungal scented isolates that were various in terms of scent types and intensities. They were bread starters like the smell, alcohol like the smell, sweet sugar like the smell, salaka like the smell and fresh sugarcane juice like smell. Several isolates emit original host like the smell in very low intensities. Persistency scent test showed that the scents were persistently emitted when cultured on PDA medium. Key Words: Scented volatile; Damask rose; microba; exsplorasi
Arteriovenous forms of congenital vascular malformations of extremities: aspects of pathogenesis
Authors: L. M. Chernukha  , O. V. Kashyrova  , G. G. Vlaykov  , O. A. Vlasenko  , V. A. Kondratyuk  , A. O. Guch  , I. V. Gomolyako  
Published: April 2019

The aim — to improve the results of treatment of patients with arterio‑venous forms (AVF) of congenital vascular malformation (CVM) of extremities based on the study of etiopathogenetic aspects of pathology.Materials and methods. Work is based on data of complex clinical research and surgical treatment of 155 patients with the arteriovenous forms of congenital vascular malformation of extremities. There were 65 (42 %) men, 90 (58 %) women, average age — 25.1 ± 10.4 years. The children’s age group (up to 18 years old) is formed of 53 (34 %) persons. The analysis of clinical material is viewed depending on the clinical‑anatomical forms of CVM, which were subdivided into 11 groups on the basis of «working» classification scheme «VASC +T»: I—VII — macrofistulous forms (trunkular, extratrunkular, combined), VIII — IX — micrоfistulous forms, X—XI — mixed or combined forms (with predominance of venous component and presence of single microfistulas). Distribution by prevalence: diffuse forms — groups I — IV, VIII, X; localized forms — groups V—VII, IX, XI. Assessment of chronic arterial and venous insufficiency for each patient was carried out.Results and discussion. Diffuse macrofistulous AVF of CVM are hemodynamically more severe, causing the hypertrophy of soft tissues and more expressed clinical displays of chronic arterial (26 (17 %)) and cardiac (25 (16 %)) insufficiency. Diffuse microfistulous CVM (group VIII) and mixed forms with existence of microfistulas (group X) are characterized by more severe manifestations of chronic venous hypertension (88 (56.8 %)) and vascular‑bone syndrome (56 (36 %)). The most severe manifestations of systemic hemodynamic disorders were revealed in diffuse macrofistulous forms, although, according to most parameters, disturbances in diffuse macro‑ and microfistulous AVF of CVM are comparable and of the same type. Pathomorphological (66 (45.8 %)) and immunohistochemical studies (10.7 %) revealed the presence of proliferative activity of angiomatous tissues and degenerative changes in the walls of the angiodysplastic vessels both due to developmental defects and pathological disorders of hemodynamics. The source of progression of AVF of CVM is vessels of the microvasculature (capillaries) and microfustulas, proceeding from the level of VEGF and Ki‑67.Conclusions. The study of hemodynamic and pathomorphological aspects of the pathogenesis of AVF of СVM is necessary for planning of an individual differentiated approach in diagnosis and treatment, depending on the clinical and anatomical form of the disease.
Clinical and anamnestic characteristics of patients with acute pulmonary embolism
Authors: V. I. Tseluyko  , L. N. Yakovleva  , S. N. Sukhova  , O. V. Radchenko  , N. V. Diolog  
Published: April 2019

The aim — to analyze the features of the course and the main factors of development of pulmonary embolism (PE).Materials and methods. During the period from January 1, 2014 until July 1, 2018, 774 patients with acute pulmonary embolism aged from 21 to 88 years (average age 59.1 ± 13.9 years) were hospitalized at Kharkiv City Clinical Hospital №8. Intra‑hospital mortality was 4.9 % (38 patients). The criterion for inclusion in the study was acute pulmonary embolism, diagnosed by the results of multispiral computed tomographic angiography of the pulmonary arteries. All patients underwent general clinical examination, standard transthoracic echocardiography and ultrasound doppler examination of the lower extremity veins. The risk of venous thromboembolism and prognosis according to generally accepted scales were evaluated.Results and discussion. Most of the examined patients (83.8 %) had 2 and more risk factors for venous thromboembolism. Every fifth patient had an oncological disease, in particular, in 5.8 % of patients, it was first detected in a targeted search. According to the MCT‑angiography of the pulmonary artery and/or echocardiography, 72.8 % of patients had signs of dysfunction of the right ventricle. Persons with high and moderately high risk of early death (68.6 %) whose treatment regimens included thrombolytic therapy prevailed among the examined patients. In treatment of patients with low and moderate‑low risk, preference was given to new oral anticoagulants.Conclusions. In the period from 2014 to 2017 there was an increase in cases of acute pulmonary embolism verified by MCT‑angiography, which can be explained by an increase in the incidence of pulmonary embolism and its better detection. The disease was diagnosed with the same frequency in men and women, but women were almost 10 years older than men. Hospitalization of patients with pulmonary embolism in one hospital improves the quality of treatment, as evidenced by a decrease in mortality from 8.8 % in 2014 to 3.9 % in 2017.
Results of treatment of patients with carotid artery stenosis in pathology of vision
Authors: I. S. Pulyaeva  , V. V. Boyko  , V. V. Sardaryan  , V. A. Prasol  , M. I. Kovtun  
Published: April 2019

The aim — to analyze the results of complex treatment of patients with carotid artery stenoses and abnormalities of the organ of vision.Materials and methods. The analysis was conducted of the results of the examination and treatment of 27 patients with changes in the visual fields and lesions of the carotid arteries in V. T. Zaitsev Institute of General and Emergency Surgery and Medical Center «Ophthalmika» during 2017—2018 years. The patients were divided into 2 groups: I group — 16 patients in whom the defeat of the carotid arteries required only conservative therapy and II group — 11 patients with hemodynamically significant stenosis or an unstable plaque that underwent carotid endarterectomy.Results and discussion. We evaluated the immediate results of the operation in a comprehensive manner based on the degree of change in clinical status, the presence of postoperative complications and data of instrumental studies. In I group on the background of disaggregant therapy and treatment with statins, the progression of the disease in the form of a narrowing of the visual fields on static perimetry was fixed in two cases, while stenosis of the internal carotid artery increased by 5 — 10 %. In II group, all operated patients had no complications in the postoperative period, enlargement of the fields of vision and expansion of the visual fields and improvement in visual acuity was noted in 10 patients. Complications in the form of a stroke, reduced vision and bleeding were not observed in any case. In two cases, on day 3, reperfusion syndrome manifested itself.Conclusions. Patients with a concentric narrowing of the visual fields and central scotomas should be screened for lesions of the carotid arteries. In case of hemodynamically significant stenosis or the presence of an unstable plaque, the patients must undergo carotid endarterectomy at the first stage, which reduces the risk of ischemic stroke and improves visual acuity and visual field.
Thrombosis of perforating veins: frequence, structure, features of treatment and connection with cancer
Authors: Ye. Yu. Hardubey  , M. F. Vatsuro  , O. I. Danilenko  , Yu. V. Sidorko  
Published: April 2019

Acute varicose vein thrombosis is one of the main varicose disease complications. It causes deep vein thrombosis in 10 — 25 % and pulmonary embolism — in 10 % of patients.The aim — to study the frequency, nature, distribution of non‑systemic varicositosis of the lower extremities and the features of its treatment, as well as to establish its connection with oncological diseases.Materials and methods. For the period of 2010 — 2015, 546 patients with acute varicotrombosis were hospitalized, 28 of them (5.1 %) — with varicotrombosis outside the system of the large or small saphenous vein. 13 of them were men (46.4 %) and 15 — women (53.6 %). The average age of the patients was 48.2 years, the average period of existence of varicose veins — 12 years, the average duration of illness — 5.2 days. All patients underwent duplex vascular scaning, general clinical examinations and initial search for cancer.Results and discussion. Thrombosis of varicose veins which were connected with deep veins through perforating veins was found in all patients. Flotation into deep veins was found in 13 (43.6 %) cases, perforating vein thrombosis — in 11 (39.3 %), thrombosis of varicose branch of the perforating vein system — in 4 (17.9 %) cases. 24 (85.7 %) patients had a surgery, 4 (14.3 %) were treated conservatively. Malignancy was identified in 5 (17.9 %) patients for the first time in their lives after the conducted search for cancer.Conclusions. Frequency of perforating vein thrombosis constituted 5.1 %, progression of perforating vein thrombosis to deep vein thrombosis — 46.4 %.The main method of treatment is surgery in order to prevent progression of perforating vein thrombosis to deep vein thrombosis and pulmonary embolism. The presence of malignancy in patients with non‑systemic varicotrombosis was 17.9 %.
Efficiency of various methods of surgical treatment of chronic diseases of lower limb veins (analysis of our experience)
Authors: K. K. Karpenko  , V. A. Chernyak  , D. Ye. Dubenko  , O. V. Kuzmenko  , E. S. Bilyk  , P. F. Muzychenko  
Published: April 2019

The article deals with classification issues, the current state of medical and surgical treatment of chronic diseases of the veins of the lower extremities, widely used in world practice, innovative domestic developments based on electrocoagulation and electric welding technologies, as well as their comparative characteristics among themselves and with laser methods based on their own experience.The aim — to compare effectiveness of open and minimally invasive surgical techniques in patients with varicose disease (VD) and post‑thrombotic disease (PTD) of the lower extremities, to assess the possibility of Ukrainian high‑tech developments using.Materials and methods. Analysis was conducted of surgical treatment of 94 patients with VD for the period from 2014 to 2017 and 81 patients with PTD (the period from 2002 to 2010) in the «Olexandrivska» clinical hospital in Kyiv.Results and discussion. The results of treatment were evaluated at 4 weeks, 3 months, and 6 months after surgery by sonographic criteria, the presence of local edema, the dynamics of the trophic changes in soft tissue of the shin. After 1 month, a slight improvement was fixed at 18 % of the patients of the main group, moderate improvement — at 74 %, significant improvement — at 8 %. In 3 months the estimated effectiveness was 2 %, 12 %, 86 %, in 6 months — 2 %, 6 %, 92 %, respectively. The average length of hospital stay for patients in the main group was 2.4 ± 0.4 days, whereas in the control group this indicator was 5.2 ± 1.2 days.Conclusions. Endovenous laser coagulation and subfascial endoscopic dissection are effective, low‑impact methods for treating lower limb varicose and post‑thrombotic diseases of the lower extremity veins and should actively supplant open methods of surgical treatment. Ukrainian developments using high‑frequency electric welding and electrocoagulation technologies could take leading positions in phlebology.
Methods of treating patients with non‑restructuring chronic critical lower limb ischemia using autologous mesenchymal stem cells
Authors: N. Yu. Litvinova  , V. A. Chernyak  , O. I. Kefeli‑Yanovska  , D. E. Dybenko  
Published: April 2019

The prevalence of peripheral arteries disease (PAD) ranges from 3 to 10 % in the general population, reaching 15 — 20 % in subjects older than 70 years. PDA affects 27 million people in Europe and the USA. The annual number of cases of critical lower limbs ischemia (CLLI) is from 500 to 1000 new cases per 1 million of the population, with a high level among patients with diabetes.The aim — to improve the results of treatment of patients with CLLI through the development and implementation of methods of autologous transplantation of multipotent mesenchymal stem stromal cells.Materials and methods. The study was conducted on the basis of two clinical centers of the Department of Surgery № 4 of O. O. Bogomolets National Medical University — vascular surgery department of Alexandrovska clinical hospital and clinic of vascular surgery of the Main military hospital Ministry of Defence of Ukraine and had the following design: 1 period — screening, 2nd period — randomization and distribution of patients by treatment groups, 3rd — treatment, 4th — period of observation (3 years). Sampling of subcutaneous fat, cultivation and transplantation of autologous mesenchymal stem cells according to the method proposed by us were carried out to 41 patients.Results and discussion. The frequency of preservation of the lower limbs in patients who were injected with adipocyte stem cells (ASC) was statistically significantly higher than in patients who used other types of therapy, and was 82 % after three years of follow‑up.Conclusions. Therapeutic mechanism of action of ASC, research on of animal models and in patients, mostly lies in the fact that the growth of blood vessels occurs in ischemic lower limb, possibly, through the interaction of local vascular and inflammatory cells and injected ASC. As a result, patients who received this type of therapy had a smaller percentage of performed amputations than patients who did not receive it.
Assessment of frequency of cranial nerve lesions after carotid artery surgery
Authors: Т. I.  Kobza  
Published: April 2019

The aim — to improve the methods of treatment of carotid pathology by analyzing the frequency of the cranial nerves’ lesions through generalization of the literary sources and the results of own observations.Materials and methods. A review of the latest world‑wide‑scale studies (NYCAS, ECST, NASCET, CREST, VSGNE) and analysis of statistical data, dedicated the problem of cranial nerves’ lesions after surgical interventions on the carotid arteries, was conducted. The frequency of cranial nerves’ lesions was retrospectively analyzed in the total number of operations on brachiocephalic arteries at vascular surgery department of Lviv Regional Clinical Hospital for the period from 2008 — 2017 years (1373 operations). The presence of stable or transient cranial nerves’ lesions in the early and late postoperative period was documented by the neuropathologist and the otolaryngologist.Results and discussion. According to world statistical studies, the frequency of cranial nerves’ lesions after surgical interventions on the carotid arteries is 3 — 27 %, according to the European Association of Vascular Surgeons — 5.1 %. The results of American studies are closed to this value: NYCAS — 5.5 %, NASCET — 8.6 % and CREST — 4.7 %. The most frequently injured are: n. hypoglossus, n. glossopharyngeus and n. auricularis magnus. At vascular surgery department of Lviv Regional Clinical Hospital, the frequency of cranial nerves’ lesions after surgical interventions on the carotid arteries was 7.2 %. The most frequent were injuries of n. vagus, n. hypoglossus and n. glossopharyngeus. Clinical symptoms of injury largely regressed during 1 year. In the cases of atherosclerotic lesions of carotid arteries, the higher rates of postoperative neurological symptoms were observed among symptomatic patients in comparison with asymptomatic ones.Conclusions. The frequency of cranial nerves’ lesions according to the data of literary sources is within the range of 3—27 %. N. vagus, n. hypoglossus, and n. glossopharyngeus have highest rate of frequency of the lesion after surgical intervention on the carotid arteries. The injury process is largely reversible within one year after surgery.
Living activities limitation of population of Ukraine due to chronic venous diseases of lower limbs
Authors: O. V. Kosynskyi  , S. O. Maryichenko  , D. L. Buzmakov  , T. V. Iorzh  
Published: April 2019

The aim — to analyze the level and structure of primary (PD) and accumulated disability (AD) due to chronic venous diseases of the lower extremities (CVDLE) over the past five years in Ukraine.Materials and methods. The analysis of primary and accumulated disability due to CVDLE was done. The data was obtained from all centers and bureaus of medical and social expertise of the regions of Ukraine and the city of Kyiv, except for Donetsk, Lugansk regions and the Autonomous Republic of Crimea. The main nosological forms that led to disability were varicose and post‑thrombotic disease (PTD) of the lower extremities. The demographic, social and gender structure of PD and AD was analyzed with consideration of severity of disability.Results and discussion. Over the past five years, in Ukraine, the PD level due to peripheral vascular diseases decreased from 0.84 to 0.76 per 10 thousand adults and from 0.69 to 0.62 per 10 thousand of working‑age population. In the structure of PD due to peripheral vascular diseases in the adult population in 2017, the proportion of CVDLE was 30.8 %. In the structure of PD of working‑age population it was 48.9 %, which was 1.3 and 1.2 times higher than the corresponding figures in 2013. The overall level of disability due to CVDLE compared with 2013 tended to decrease from 1.26 to 1.19 due to PD. Over five years, PD due to CVDLE was characterized by almost two times increase in the number of young people with disabilities, with a simultaneous 1.3 times decrease in the proportion of persons with disabilities in mature age due to PTD. In the group of patients under 30 years of age, the disability group due to CVDLE was initially established in 2.8 % of cases. In the structure of AD due to PTD, an increase in the number of persons of mature age was determined.Conclusions. In the structure of peripheral vascular diseases over five years, the proportion of CVDLE increased by 1.3 times among adults and 1.2 times — among the working‑age population. The main cause of PD due to CVDLE remains PTD (71.4 %) with an increase in the incidence of severe disability by 1.2 times. Over the course of five years, the proportion of PD among young people due to varicose vein disease increased by 1.9 times, indicating a low level of medical rehabilitation. The analysis of the level and structure of disability due to CVDLE over the past five years in Ukraine has identified a negative tendency, which requires improved approaches to medical and social expertise and rehabilitation.