bluuebunny/crossref_metadata_2025_split huggingface dataset:
Determinants of Success for Women Entrepreneurs: An Examination of Small and Medium‐Sized Women‐Led Businesses in India's Emerging Market
Authors: Tanzeela  , Kumar Dinesh , Mehraj Danish 
Published: December 2024

ABSTRACTWomen entrepreneurs play a crucial role in the economic development of nations, particularly in developing countries where their contribution becomes even more significant. This underscores the importance of women‐owned small and medium enterprises (SMEs) and their achievements as entrepreneurs. Consequently, this study aims to expand the entrepreneurship literature by investigating the impact of factors such as personality traits (PT), motivation and commitment (MC), the availability of financial resources (AFR), and economic factors (EC) on the entrepreneurial success (ES) of women‐led SMEs. Data was collected from 255 women‐owned SMEs using a stratified sampling technique, and a multi‐SEM approach was applied to analyze the data. The results from structural equation modeling (SEM) revealed that PT, MC, AFR, and EC directly influence ES. Notably, PT and EC emerged as the most significant factors associated with ES. These findings can serve as valuable guidance for business practitioners and policymakers when formulating strategies to promote and support women entrepreneurs, who, in turn, can contribute significantly to sustainable economic growth in their respective countries.
Differences in Ancestry and Presence of Gastric Precursor Lesions in Individuals With Young‐ and Average‐Onset Gastric Cancer
Authors: Magahis Patrick T. , Cornet Nicole , Tang Laura , Arora Kanika , Hingorani Neha , King Stephanie , Markowitz Arnold J. , Schattner Mark , Shimada Shoji , Maron Steven B. , Vardhana Santosha , Lumish Melissa , Cercek Andrea , Janjigian Yelena Y. , Coit Daniel , Mendelsohn Robin B. , Berger Michael F. , Strong Vivian E. , Stadler Zsofia K. , Laszkowska Monika 
Published: December 2024

ABSTRACTBackgroundThere has been a paradoxical rise in young‐onset gastric cancer (YOGC), defined as gastric cancer (GC) diagnosed before age 50. Precursor lesions may contribute to pathogenesis, though their role in progression to different histologic subtypes is unclear. The impact of self‐reported race is also poorly characterized and may be unreliable as a proxy for genetic differences. We aimed to compare differences in histology and genetic ancestry between YOGC and average‐onset gastric cancer (AOGC).MethodsThis retrospective cohort included all patients with GC at Memorial Sloan Kettering (MSK) from January 2013 to March 2021. Data on demographics, tumor characteristics, and precursor lesions were collected. Genetic ancestry was inferred from MSK‐Integrated Mutation Profiling of Actionable Cancer Targets panel.ResultsOf 1685 individuals with GC, 290 had YOGC. Compared to AOGC, individuals with YOGC tended to be female, Hispanic, foreign‐born, and feature diffuse‐type histology. YOGC was less likely to have precursor lesions, including intestinal metaplasia (20% vs. 37%, p < 0.01) and dysplasia (4% vs. 14%, p < 0.01). Of 560 patients with ancestry data, 127 had YOGC. Admixed, East Asian, and South Asian ancestries were more likely to present with YOGC while Europeans presented with AOGC. Intestinal metaplasia was enriched among East Asians, maintained when stratifying by histology and GC onset.ConclusionsWe observed YOGC was more common in East and South Asians, and while YOGC may be less likely to develop in the setting of precursor lesions these high‐risk states may also be enriched in East Asians. Future research is needed to understand drivers behind such differences and outcome disparities given these individuals may be less amenable to endoscopic interventions.
Targeting Tumor Endothelial Cells by EGCG Using Specific Liposome Delivery System Inhibits Vascular Inflammation and Thrombosis
Authors: Jia Zi , Maishi Nako , Takekawa Hideki , Matsuda Aya Yanagawa , Nakade Taisei , Nakamura Takashi , Harashima Hideyoshi , Hida Yasuhiro , Hida Kyoko 
Published: December 2024

ABSTRACTBackgroundInflammation is one of the hallmarks of cancer and is associated with tumor growth. Tumor endothelial cells (TECs) demonstrate inflamed phenotypes. Endothelial inflammation initiates thrombus formation, which is the second cause of cancer‐related deaths. Epigallocatechin‐3‐O‐gallate (EGCG), a natural compound in green tea, has demonstrated an anti‐inflammatory effect. However, the tumor progression inhibition effect of EGCG by targeting TEC inflammation remains unclear. This study addresses the anti‐tumor effect of EGCG, especially its anti‐inflammatory role in TECs.MethodsIn vitro, the effect of EGCG on TECs were studied using real‐time quantitative PCR and immunofluoresence to analyza gene and protein expression. In vivo, a cyclic RGD liposome delivery system (MEND) was employed to efficiently deliver EGCG to TECs in tumor‐bearing mice.ResultsIn vitro, EGCG significantly reduces inflammatory cytokine expression, including tumor necrosis factor‐α, interleukin‐6, IL‐8, and IL‐1β through NF‐κB signaling inhibition. Additionally, von Willebrand factor reduction in TECs, which is involved in platelet adhesion and thrombosis formation, was analyzed. Our results revealed that EGCG‐MEND significantly inhibited TEC inflammation and thrombus formation in tumors. Additionally, EGCG‐MEND improved tumor immunity by reducing programmed death‐ligand 1 expression and promoting high endothelial venule formation by recruiting CD8+ T cells.ConclusionOur results indicate the anti‐tumor potential of EGCG‐MEND in normalizing the inflammatory immune microenvironment and inhibiting thrombosis by targeting TEC.
Molecular Networks as Strategy for Dereplication of Steroidal Alkaloids of Herbarium Samples of Solanum jabrense Agra and M. Nee, an Endemic and Unexplored Species
Authors: Lima e Silva Anauara , de Medeiros Brito Thiago Araújo , Agra Maria de Fátima , Sobral da Silva Marcelo , Tavares Josean Fechine 
Published: December 2024

ABSTRACTSolanum jabrense is an endemic species from Brazil, distributed in the phytogeographic domains of the Caatinga and Atlantic Forest, in the states of Northeast. Solanum L. species have great economic importance not only because they are used in human food, but also because they present several secondary metabolites, especially glycosylated steroidal alkaloids, giving them medicinal properties. Recently, dry herbarium specimens have been used to identify metabolites of interest preserved even after years of storage, using a simple and fast method of extraction and analysis by liquid chromatography (LC) coupled to mass spectrometry (MS). Dereplication techniques aided by molecular networks (MNs) were used to analyze the chemical composition from samples of S. jabrense herbarium specimens and to identify chemical markers and bioactive molecules with potential medicinal use. From the LC–MS/MS dataset of the crude extracts and a standard (solasodine), an MN was generated that resulted in the dereplication of 19 spirosolane‐type alkaminas. Our results suggest that dereplication using fragments of dried Solanum specimens is a quick tool to identify potential conserved metabolites, being useful not only for chemotaxonomy and metabolomic but also for the discovery of new molecules in natural products.
New Frontiers for Orbital Atherectomy—Crossing an Uncrossable Chronic Total Occlusion
Authors: Helal Ayman , Farooq Mohsin 
Published: December 2024

ABSTRACTManaging chronic total occlusions (CTOs) in coronary artery disease remains a significant challenge, especially in cases where standard techniques fail to cross the lesion. Uncrossable lesions are rare but require innovative strategies for successful treatment. Orbital atherectomy, traditionally used for calcified plaques, may offer a solution in these cases. We present the case of a 62‐year‐old male with exertional chest pain and a CTO in the right coronary artery (RCA). The patient had a positive stress echocardiogram for inducible ischemia despite optimized medical therapy. Multiple conventional techniques, including ballooning, microcatheter use, and laser atherectomy, failed to cross the proximal cap of the CTO. After these methods proved ineffective, orbital atherectomy using the DiamondBack 360 system successfully crossed the lesion and enabled subsequent balloon angioplasty and stenting. This may be the first reported case where orbital atherectomy was used after the failure of laser and other techniques. The case highlights the role of orbital atherectomy in the treatment of uncrossable CTOs, expanding its application beyond calcified lesions. The versatility of this technology, particularly when other methods fail, underscores its importance as an adjunctive tool in complex PCI. In conclusion, orbital atherectomy should be considered a valuable option for crossing uncrossable coronary CTOs, especially when standard and advanced techniques, including laser atherectomy, fail. This case broadens the scope of its use in coronary intervention, providing a new perspective on tackling resistant lesions.
Predicting Liquid Organic Hydrogen Carrier Saturation in Dehydrogenation Cell Gas Diffusion Layers for Hydrogen Storage
Authors: Farsi Aida , Zhu Lijun , Seip Tess , Bazylak Aimy 
Published: December 2024

AbstractDehydrogenating methylcyclohexane (MCH) as a liquid organic hydrogen carrier offers a promising method for producing stored hydrogen. However, the transport properties of the gas diffusion layers (GDLs) in dehydrogenation cells (D‐cells) have not yet been optimized for high reactant saturation at the GDL‐catalyst layer (CL) interface, which is crucial for increasing hydrogen production. We applied pore network modeling (PNM) to quantify the anisotropic transport properties and local saturation of MCH in GDLs with distinct microstructures. We demonstrate that GDLs with larger mean pore diameters and lower tortuosity exhibit higher MCH permeability and diffusivity. Moreover, a high porosity at the GDL‐CL interface increases MCH saturation (from 0.05 to 0.11), highlighting the impact of local GDL porosity on MCH supply to the catalyst. The results of the invasion percolation simulation revealed that smaller pore sizes lead to a longer MCH transport pathway to the GDL‐CL interface, thereby reducing MCH saturation at this interface (by more than twofold), which hinders reactant availability for hydrogen production. Therefore, we recommend a GDL that combines large pores for efficient MCH flow and small pores close to the CL for liquid retention to enhance MCH utilization in the anode of D‐cell, particularly at high current densities.
Current Collectors for Supercapacitors: Objectives, Modification Methods and Challenges
Authors: Liu Miao , Liu Ji‐Chi , Zhang Yue , Han Xu , Li Hui , Huang Zi‐Hang , Ma Tianyi 
Published: December 2024

AbstractSupercapacitors (SCs) have emerged as promising candidates for efficient and sustainable energy storage devices due to their unique merits, including high power density and long lifespan. However, despite these advantages, SCs face significant challenges related to their relatively low energy density. Current collectors are critical components of SCs, which significantly impacts the efficiency and overall performance by connecting active materials and external devices. However, the reviews on SCs are predominantly focused on electrode active materials or electrolyte materials, with insufficient comprehensive summaries regarding current collectors. This review focuses on the research progress related to current collectors in SCs. Firstly, the article outlines the modification objectives mechanism and inherent nature of SC current collectors. Building on this foundation, the authors further classify the current collector materials towards metallic, carbon‐based, polymers and other ones and highlights their modification strategies. Finally, the future development trends and challenges of SCs current collectors are comprehensively discussed.
Current‐Dependent Product Distribution and Reaction Mechanisms of Glycerol Electrooxidation on Nickel
Authors: Ng Eva , Mesa Camilo A. , Más‐Marzá Elena , Giménez Sixto 
Published: December 2024

AbstractThe Glycerol Electrooxidation Reaction (GEOR) is a promising alternative to oxygen evolution in electrochemical processes like hydrogen production and CO2 reduction. Although GEOR has attracted increasing attention, its oxidation kinetics in alkaline media are not well understood. In this study, electrochemical characterization and kinetic analysis were conducted using nickel foil as the electrocatalyst. Four galvanostatic conditions (1, 3, 5, and 10 mA cm−2) were evaluated to study product distribution. Increasing the current density from 3 to 5 mA cm−2 led to a fivefold decrease in formate production, indicating a shift in GEOR selectivity within the Oxygen Evolution Reaction (OER) region. At 10 mA cm−2, formate remained as major product, followed by glycolate and glycerate, while tartronate and oxalate production were significantly inhibited, reducing the total Faradaic Efficiency (FE) by half relative to 5 mA cm−2. Rate constants showed increased kinetics for glycerate, glycolate, oxalate, and tartronate as current increased, surpassing formate production at 5 mA cm−2. Spectroelectrochemical measurements revealed the reaction order for GEOR (αGEOR ~1) and OER (αOER ~3), showing that GEOR proceeds via a more efficient oxidative pathway, requiring interaction with just one NiOOH species, while OER involves three highly oxidized Ni‐species.
Proposing Oxalic Acid as Chemical Storage of Carbon Dioxide to Achieve Carbon Neutrality
Authors: Scarpa de Souza Edson Leonardo , Neumann Helfried , Roque Duarte Correia Carlos , Beller Matthias 
Published: December 2024

AbstractIncreasing emissions of carbon dioxide into the atmosphere due to the use of fossil fuels and ongoing deforestation are affecting the global climate. To reach the Paris climate agreement, in the coming decades low emission technologies must be developed, which allow for carbon removal on a Gt per year‐scale. In this regard, we propose the electrochemical conversion of carbon dioxide to oxalic acid as a potentially viable pathway for large scale CO2 utilization and storage. Combined with water oxidation, in principle this transformation does not need stoichiometric amounts of co‐reagents and minimize the necessary electrons for the reduction of carbon dioxide.
Enzymatic Upgrading of Biomass‐Derived Aldoses to Rare Deoxy Ketoses Catalyzed by Transketolase Variants
Authors: Arbia Giuseppe , Joly Muriel , Nauton Lionel , Leogrande Camilla , Tittmann Kai , Charmantray Franck , Hecquet Laurence 
Published: December 2024

AbstractA sustainable, convenient, scalable, one‐step method for the two‐carbon chain elongation of cheap and biomass‐derived pentoses (l‐arabinose, and 2‐deoxy‐d‐ribose) and hexose l‐rhamnose was developed to produce Cn+2 deoxy ketoses (C‐7 and C‐8) using transketolase, an enzyme catalyzing the quasi‐irreversible transfer of a ketol group from an α‐keto acid to an aldehyde. Deoxygenated ketoses ‐ commonly obtained by chemical synthesis ‐ were afforded through a suitable combination of both nucleophile and electrophile substrates in the presence of rationally designed TK variants. Pyruvate as nucleophile with pentose l‐arabinose (C‐5) as electrophile gave 1‐deoxy‐L‐gluco‐heptulose (C‐7), while ß‐hydroxypyruvate (HPA) as nucleophile with acceptors 2‐deoxy‐d‐ribose (C‐5) and 6‐deoxy‐l‐mannose (l‐rhamnose) (C‐6) led to formation of 4‐deoxy‐d‐altro‐heptulose (C‐7) and 8‐deoxy‐l‐glycero‐l‐galacto‐octulose (C‐8), respectively. These three deoxy ketoses were easily obtained with efficient TK variants under mild conditions with complete or high substrate conversions, good to excellent yields and high diastereoselectivities. This strategy offers interesting prospects to study the biological activities of these three rare and valuable deoxy ketoses on various cellular targets.
Endothelial Angpt2 Promotes Adipocyte Progenitor Cells Maturation to Increase Visceral Adipose Tissue Accumulation
Authors: Yi Xianhao , Ling Jiapu , Tang Yan , Cai Jingjing , Zhu Shaihong , Zhu Liyong 
Published: December 2024

ABSTRACTAimsVisceral adipose tissue (VAT) accumulation is essential for the occurrence and development of obesity and related metabolic diseases. Currently, the specific mechanism of VAT accumulation is still unclear.Materials and MethodsWe searched the Gene Expression Omnibus database to obtain single‐cell RNA sequencing (scRNAseq) data for VAT in patients with a normal body mass index (BMI), obesity, or morbid obesity. By using PCR, WB, immunofluorescence staining, and flow cytometry analysis, we validated the interactions between macrophages, endothelial cells (ECs), and adipocyte progenitor cells (APCs), as well as the underlying mechanism, in VAT. Finally, we tested the findings in obese mice using recombinant proteins and adeno‐associated virus infection.ResultsOne study with human scRNAseq data was included. This study collected 13‐VAT from 5 individuals with obesity and diabetes, 9 individuals with obesity, and 1 individual with a normal BMI. The proportion of inflammatory macrophages is substantially increased in obese and diabetic patients. ECs have the most active interactions with other cells. Notably, the activation of JAK1/STAT3 is one of the reasons for the increase in inflammatory endothelial cells and can promote the secretion of angiopoietin‐2 (Angpt2) and induce APCs to transition from mesothelin (MSLN) to complement factor D (CFD) expression via integrin‐α5β1 signalling. This phenotypic transition promotes APC differentiation into mature adipocytes and accelerates VAT accumulation. These observations were further validated in an in vitro model and an in vivo study using Angpt2 recombinant proteins and blocking the expression of Angpt2 by adeno‐associated virus infection.ConclusionsECs are essential for promoting VAT accumulation by facilitating APC differentiation from MSLN to CFD phenotype. This process is driven by Angpt2 from ECs upon JAK1/STAT3 signalling activation under metabolic stress.
Enhancing Motivation to Reduce Restrictive Eating: A Novel Approach
Authors: Harris Lauren M. , Rogers Megan L. , Broshek Catherine E. , Campione Marie T. , Park Esther C. , Robison Morgan , Schafer Katherine M. , Joiner Thomas E. 
Published: December 2024

ABSTRACTObjectiveDespite growing interest in leveraging motivational techniques to address restrictive eating, it is not yet clear how to most effectively promote motivation to reduce this behavior. Drawing from a behavioral economic framework, the present study evaluates a novel approach for increasing motivation to address disordered eating by amplifying the potential benefits of reducing dietary restriction and the consequences of maintaining disordered behaviors.MethodA sample of 126 undergraduate students engaging in restrictive eating participated in a 7‐day online experiment. Participants were randomized to one of four conditions: Amplified Benefits and Consequences, Amplified Benefits, Amplified Consequences, or a control condition. Growth curve models were estimated to examine the extent to which experimental conditions led to changes in eating pathology and motivation over the study period.ResultsInitial reductions in dietary restraint were observed in conditions where the benefits of reducing restriction were amplified; however, these reductions were not sustained over the 7‐day study period. The greatest increases in motivation were observed when both the benefits of reducing restriction and the consequences of maintenance were amplified.DiscussionInterventions designed to enhance motivation alone are unlikely to yield sustained reductions in eating disorder symptoms and therefore should be accompanied or followed by targeted interventions which directly address restrictive eating behaviors and maladaptive cognitions about shape and weight.
Rescue or murder? The effect of prey adaptation to the predator subjected to fisheries
Authors: Shang Yangke , Kasada Minoru , Kondoh Michio 
Published: December 2024

AbstractThe concept of “indirect evolutionary rescue” refers to the evolutionary adaptation of an interacting species that can save a focal species from extinction in an unfavorable environment. Although theories suggest that indirect evolutionary rescue may have essential impacts on catchments in the context of fisheries where artificial selection pressure from fishing can drive evolution, its generality and conditions remain uncertain. In this study, by investigating how prey adaptation affects the persistence of a predator subjected to selective harvest with an eco‐evolutionary predator–prey model, we find that prey adaptation tends to deteriorate (facilitate) predator persistence when predator's evolvability is high (low). In the system where the predator possesses high evolvability, selection by fisheries inhibits a predator's adaptation to prey, allowing the prey to escape predation by adaptation. Prey adaptation will affect predator persistence negatively, leading to evolutionary murder. Conversely, in the system where the predator's evolvability is low, the removal of predator individuals by fisheries relaxes predation pressure on prey, making the prey less defensive. Vulnerable prey affects predator persistence positively, resulting in indirect evolutionary rescue. The context‐dependent response of natural resources to fisheries identified in this study suggests that the eco‐evolutionary interplay should be considered for better natural resource management.
Comparing Historical and Contemporary Observations of Avian Fauna on the Yáláƛi (Goose Island) Archipelago, British Columbia, Canada
Authors: Obrist Debora S. , Pendray Elizabeth Jane , Field Rachel D. , Housty William , Dennert Allison M. , Scoville Gerald W. , Darimont Chris T. , Reynolds John D. 
Published: December 2024

ABSTRACTIn an era of global change, historical natural history data can improve our understanding of ecological phenomena, particularly when evaluated with contemporary Indigenous and place‐based knowledge. The Yáláƛi (Goose Island) Archipelago is a group of islands in Heiltsuk (Haíɫzaqv) territory on the Central Coast of British Columbia, Canada. Not only has this region been important to the Heiltsuk for millennia but also it is both a federally and internationally recognized important bird area. In this study, we compare data collected by Charles J. Guiguet, a biologist who documented bird communities at Yáláƛi in the summer of 1948, to three different contemporary surveys and to citizen‐science data. We find that the relative abundances of forest bird species (i.e., birds that use the terrestrial island ecosystems) in 1948 differed to those observed in systematic surveys in 2011. While Orange‐crowned Warblers, Dark‐eyed Juncos, and Red Crossbills comprised 55% of detections by Guiguet in 1948, the three most abundant species in 2011 were Bald Eagles, Varied Thrushes, and Pacific Wrens, and these accounted for only 25% of detections. Although we could not make a quantitative comparison, we provide summaries of each species observed in surveys or reported on eBird. We also incorporate Heiltsuk place‐based knowledge to enrich our discussion of the variability in bird communities over time, from how changes in mammal communities and human use may have shaped vegetation dynamics to how large‐scale natural phenomena impacted topography. To understand which birds are present and how their communities are changing over time, we recommend continued monitoring of the bird communities at Yáláƛi.