bluuebunny/crossref_metadata_2025_split huggingface dataset:
Germline mosaicism in an α‐thalassemia family: Incidental identification by prenatal ultrasound
Authors: Xu Li‐Li , Liu Ying‐Na , Zhen Li , Li Dong‐Zhi 
Published: July 2019

What's already known about this topic?

In almost all cases of Hb Bart's hydrops fetalis, α0‐thalassemia can be confirmed by testing of parental blood.
Germline mosaicism occurs most of the time in autosomal dominant and X‐linked recessive disorders.
What does this study add?

The present case is the first documentation of germline mosaicism for an α‐thalassemia deletion.
Since almost all fetuses affected with Hb Bart's hydrops fetalis present with cardiomegaly on ultrasound, sonographers in regions with high α‐thalassemia prevalence should be sensitive to the cardiothoracic ratio.
Concordance of hospitalizations between Clinical Practice Research Datalink and linked Hospital Episode Statistics among patients treated with oral antidiabetic therapies
Authors: Saine M. Elle , Carbonari Dean M. , Newcomb Craig W. , Gallagher Arlene M. , Blak Betina T. , Roy Jason A. , Wood Jennifer , Cardillo Serena , Hennessy Sean , Strom Brian L. , Lo Re Vincent 
Published: July 2019

AbstractPurposeThe ability of the Clinical Practice Research Datalink (CPRD) to ascertain all‐cause hospitalizations remains unknown. We determined the proportion of hospitalizations in CPRD that were also recorded in Hospital Episode Statistics (HES), and vice versa, among patients initiating oral antidiabetic (OAD) therapy.MethodsWe conducted a retrospective cohort study from October 2009 to September 2012 among OAD‐treated patients registered with general practitioners who contribute to CPRD and consent to HES linkage. In CPRD, we identified initial hospitalizations for each calendar year by an Inpatient Referral, Consultation Type code, or Read code indicating an inpatient episode and determined if an admission date was recorded in HES within ±30 days. We then identified initial HES admission dates and determined if a hospitalization was documented in CPRD within ±30 days. Sensitivity analyses were conducted utilizing HES discharge, rather than admission, dates.ResultsAmong 8574 OAD‐treated HES‐linked patients in CPRD, 6574 initial hospitalizations across the study period were identified in CPRD, and 5188 (78.9% [95% CI, 77.9%‐79.9%]) were confirmed by a HES admission date within ±30 days (median difference, ±3 days [IQR, 1‐7 days]). Among 8609 initial hospital admissions in HES, 4803 (55.7% [95% CI, 54.7%‐56.8%]) hospitalizations were recorded in CPRD within ±30 days (median difference, ±4 days [IQR, 1‐9 days]). Similar results were observed using HES discharge dates.ConclusionA substantial minority of patient‐level hospitalization data are nonconcordant between HES and CPRD. Pharmacoepidemiologic studies within CPRD that seek to identify hospitalizations should consider linkage with HES to ensure adequate ascertainment of inpatient events.
National trends in hydroxyurea and opioid prescribing for sickle cell disease by office‐based physicians in the United States, 1997‐2017
Authors: Su Zhuo Tony , Segal Jodi Beth , Lanzkron Sophie , Ogunsile Foluso Joy 
Published: July 2019

AbstractPurposeTo identify trends in physician drug prescribing practices for sickle cell disease (SCD).MethodsWe used data from the National Disease and Therapeutic Index to evaluate medications prescribed to children (definition: aged 19 years or younger) and adults (20 years or older) with SCD by office‐based physicians in the United States during 1997 to 2017. Prescriptions were evaluated in 3‐year intervals.ResultsThe proportion of SCD visits that included new/continued hydroxyurea prescriptions increased from less than or equal to 8% before 2009 to 33% in 2015 to 2017. The increase was significant in visits by children (2.5% in 1997‐1999 to 47% in 2015‐2017; P = .003 by Spearman's rank‐order correlation) but not in adults (6.9% to 11%; P = .12). Opioids, started/continued in 13% (lowest 3‐year average) to 35% (highest) of visits by children and 55% to 81% of visits by adults, remained the most frequently prescribed medications for SCD overall. There were no significant changes over time in opioid prescribing for adults (P = .64) or children (P = .38). Hematologists/oncologists accounted for a higher proportion of visits by children (67.2% over 1997‐2017) than adults (25.2%), while emergency medicine visits were higher in adults (14.0%) than children (2.6%).ConclusionsThis study suggests a robust increase in hydroxyurea prescribing for children with SCD. The BABY HUG trial, which demonstrated safety and efficacy of starting hydroxyurea in infancy and informed current SCD guidelines recommending broader use in children, may have contributed to this increase. However, hydroxyurea prescribing for adults remains infrequent and considerably lower than opioids. Barriers in access to specialist care persist for adults with SCD.
Influence of Interventions on Daily Physical Activity and Sedentary Behavior after Stroke: A Systematic Review
Authors: Kringle Emily A. , Barone Gibbs Bethany , Campbell Grace , McCue Michael , Terhorst Lauren , Kersey Jessica , Skidmore Elizabeth R. 
Published: July 2019

BackgroundEvidence suggests that frequent engagement in daily activities requiring physical activity may influence risk factors for recurrent stroke. The effects of nonpharmacological interventions on daily physical activity levels and sedentary behavior are unclear.ObjectiveTo describe the effects of interventions on levels of daily physical activity and sedentary behavior among people with stroke.MethodsOVID/Medline, CINAHL, PsycINFO, and the Cochrane Database were searched using the following search terms: stroke, rehabilitation, intervention, sedentary, physical activity, lifestyle, self‐management, and exercise. Data extraction and risk of bias assessment were conducted by two authors.ResultsThirty‐one interventions were identified that included exercise, behavior change techniques, and education components. These components were delivered alone and in varying combinations. At postintervention, between‐group effects on change scores (Cohen's d = 0.17–0.75, P < .05) or between‐group differences in odds of participating in daily physical activity (odds ratio [OR] = 2.07, P < .05) were detected in six studies, and within‐group effects in nine studies (Cohen's d = 0.21–3.97, P < .05). At follow‐up, between‐group differences in odds of participating in daily physical activity were detected in one study (OR = 2.64, P < .05), and within‐group effects in two studies (Cohen's d = 0.25, P < .05). No effects (P < .05) were detected in 17 studies.ConclusionIt may be possible to modify daily physical activity levels and sedentary behavior poststroke; however, there is insufficient evidence to suggest the superiority of a particular intervention approach. Future studies should explore the unique contributions of individual intervention components to guide development of parsimonious multicomponent interventions that are effective for promoting daily physical activity and reducing sedentary behavior among people with stroke.Level of EvidenceI.
Spanish multicentre study on morbidity and pathogenicity of tracheal bronchus in children
Authors: Moreno Marcela , Castillo‐Corullón Silvia , Pérez‐Ruiz Estela , Luna Maria Carmen , Antón‐Pacheco Juan L. , Mondejar‐Lopez Pedro , De‐la‐Serna Olga , Villa José‐Ramón , Osona Borja , Torres‐Borrego Javier , Santiago‐Burruchaga Mikel , Asensio Oscar , Andres‐Martin Anselmo , Delgado‐Pecellin Isabel , González Yolanda , Palmero Ana , Escribano Amparo 
Published: July 2019

AbstractTracheal bronchus (TRB) has been generally considered an anatomical variant of the tracheobronchial tree without a precise pathological effect. Its prevalence is estimated to be between 0.2% to 3% of all children undergoing bronchoscopy and scientific information has been limited to case reports or small case series. Our working hypothesis was that TRB could trigger by itself recurrent or persistent respiratory symptoms. The objective of this retrospective and multicentre study of children with a diagnosis of TRB, coming from the main paediatric pulmonology units of Spain, was to determine the anatomical and clinical characteristics, including comorbidities, of TRB in childhood and their impact in the patients' clinical outcomes. One hundred thirty‐three patients from 13 institutions were included in the study. Mean diagnostic age was 3.4 years and flexible bronchoscopy was the initial diagnostic method in 85% of cases. All TRB were located on the right wall of the trachea: 76% in the lower third and 24% in the carina. The most common clinical manifestations were obstructive bronchitis (53.3%) and recurrent pneumonia (46.6%), usually affecting the right upper lobe. Regarding associated anomalies, 33% had tracheomalacia, 32% congenital cardiovascular malformations, 28% gastroesophageal reflux, 22.5% congenital tracheal stenosis, and 8.3% Down syndrome. This series appears to be the most extensive published to date addressing this topic and, according to our data, TRB does not appear to be a mere incidental finding but is more likely linked to a wide range of congenital anomalies and contributes by itself to the recurrent respiratory symptomatology that these children exhibit.
Linoleic acid‐rich guava seed oil: Safety and bioactivity
Authors: Prommaban Adchara , Utama‐ang Niramon , Chaikitwattana Anan , Uthaipibull Chairat , Srichairatanakool Somdet 
Published: July 2019

Guava (Psidium guajava) is a widely consumed fruit and has been commercialized in markets. The seeds are by‐products of the processing procedures performed by the commercial guava juice industry. They are considered a nutritional resource that has been poorly utilized as they contain essential fatty acids such as linoleic acid (LA) and phenolics in abundance. In the study, guava seed oil (GSO) was used, which was obtained by hexane extraction of guava seeds to determine composition and test toxicity, cell migration, cancer cell viability, and plasmodium growth. GSO was found to be relatively nontoxic to normal hepatocytes and peripheral blood mononuclear cells, with mice for 14 days showing median lethal dose (LD50) > 10 mg/kg and rats for up to 90 days. Surprisingly, the oil inhibited the proliferation of the human erythroleukemic cells in a dose‐dependent manner with the half maximal inhibitory concentration values of 155 and 137 μg/ml at 24 and 48 hr, respectively. Importantly, GSO at 500 μg/ml was found to increase the degree of migration of keratinocytes (HaCaT). These observations suggest that edible P. guajava seed oil, which is abundant with linoleic acid and antioxidants, can promote skin wound healing and inhibit the proliferation of leukemic cells.
Comparison of pathological outcomes between robotic rectal cancer surgery and laparoscopic rectal cancer surgery: A meta‐analysis based on seven randomized controlled trials
Authors: Liao Guixiang , Zhao Zhihong , Deng Haijun , Li Xianming 
Published: July 2019

AbstractObjectiveTo compare the pathologic outcomes between robotic‐assisted rectal cancer surgery (RRCS) and laparoscopic rectal cancer surgery (LRCS) based on randomized controlled trials (RCTs).MethodsElectronic databases were searched from their inception to 7 October 2018, for RCTs involving a comparison between RRCS and LRCS. Positive circumferential resection margin (CRM), distance to the distal margin, proximal margin, the rate of complete mesorectal excision, and harvested lymph nodes were interesting of outcomes.ResultsThe positive CRM, proximal margin, and rate of complete mesorectal excision were comparable between the two techniques. RRCS resulted in better outcomes for the distance to the distal margin (mean difference: 0.83 cm, 95% confidence interval, 0.29‐1.37, P = .003).ConclusionsThe pathologic outcomes associated with the two approaches were comparable, with RRCS showing better outcomes for the distance to the distal margin. However, additional well‐designed studies are needed to assess whether the benefits of pathologic outcomes improve survival outcomes.
Functional Outcomes Following Microfragmented Adipose Tissue Versus Bone Marrow Aspirate Concentrate Injections for Symptomatic Knee Osteoarthritis
Authors: Mautner Kenneth , Bowers Robert , Easley Kirk , Fausel Zachary , Robinson Ryan 
Published: July 2019

Abstract
This study aimed to determine whether autologous orthobiologic tissue source affects pain and functional outcomes in patients with symptomatic knee osteoarthritis (OA) who received microfragmented adipose tissue (MFAT) or bone marrow aspirate concentrate (BMAC) injection. We retrospectively reviewed prospectively collected data from patients who received BMAC or MFAT injection for symptomatic knee OA. Patients completed baseline and follow-up surveys. Each survey included the Knee Injury and Osteoarthritis Outcome Score (KOOS) questionnaire, Emory Quality of Life (EQOL) questionnaire, and Visual Analog Scale (VAS) for pain. The follow-up responses were compared with baseline for all patients and between BMAC and MFAT groups. A total of 110 patients met inclusion criteria, with 76 patients (BMAC 41, MFAT 35) and 106 knees (BMAC 58, MFAT 48) having appropriate follow-up data. The BMAC group included 17 females and 24 males, with a mean age of 59 ± 11 years. The MFAT group included 23 females and 12 males, with a mean age of 63 ± 11 years. Minimum follow-up time was 0.5 years. Mean follow-up time was 1.80 ± 0.88 years for BMAC and 1.09 ± 0.49 years for MFAT. Both groups had significant improvement in EQOL, VAS, and all KOOS parameters preprocedure versus postprocedure (p &lt; .001). There was not a significant difference when comparing postprocedure scores between groups (p = .09, .38, .63, .94, .17, .15, .70, respectively). These data demonstrate significant improvement in pain and function with both MFAT and BMAC injections in patients with symptomatic knee OA without a significant difference in improvement when comparing the two autologous tissue sources. Stem Cells Translational Medicine 2019;8:1149–1156
Embracing green innovation via green supply chain learning: The moderating role of green technology turbulence
Authors: Lisi Wei , Zhu Rui , Yuan Chunlin 
Published: July 2019

AbstractWith the increasingly serious environmental contamination and growingly stringent regulatory pressures, firms should embrace green innovation by learning from their supply chain partners. Although green supply chain learning has been suggested to be a crucial approach for enhancing innovative capability, whether and under what conditions it affects green innovation is still unclear. This study investigates the influence of two dimensions of green supply chain learning (i.e., green supplier and customer learning) on two types of green innovation (i.e., green product and process innovation) and the moderating role of green technology turbulence. Survey data collected from 249 Chinese firms were used to test research hypotheses. The findings show that both green supplier and customer learning positively influence green product and process innovation. However, green technology turbulence moderates these relationships differently. Specifically, green technology turbulence strengthens the impacts of green customer learning on green product and process innovation, while weakens the impact of green supplier learning on green process innovation. The moderating effect of green technology turbulence on the link between green supplier learning and green product innovation is insignificant. These results highlight the importance of learning from supply chain partners for sustainable development and firms' agility in adapting to external technological conditions in implementing their environmental practices.
Sustainable development and economic performance: Gaps and trends for future research
Authors: do Prado Guilherme Francisco , Piekarski Cassiano Moro , da Luz Leila Mendes , de Souza Jovani Taveira , Salvador Rodrigo , de Francisco Antonio Carlos 
Published: July 2019

AbstractThe aim of this paper is to determine the existence of gaps in the literature, by investigating studies that statistically analyzed the relationship between sustainable development and economic performance. A literature review was conducted in the Web of Science and Scopus databases. The study analyzed the authors, publication years, journals involved, methodologies used, and results obtained. The identified gaps and opportunities were (a) opportunity to create or employ different measurements for financial, social, and environmental performance and (b) to use different kinds of control or moderating variables, in order to further explore the relationship between sustainable development and financial performance.
Enzyme‐Assisted Extraction of Triterpenoid Saponins from Pseuderanthemum palatiferum (Nees) Radlk. Dry Leaf Powder and Bioactivities Examination of Extracts
Authors: Huy Tran Bao , Lien Phuong Nguyen Thi , Nga Bui Kim , Oanh Huynh Ngoc , Hieu Nguyen Huu 
Published: July 2019

AbstractTriterpenoid saponins were extracted from of Pseuderanthemum palatiferum (Nees) Radlk. dry leaf powder by using enzyme‐assisted extraction method. Effects of single factors on total saponins content (TSC) were investigated. Then, a full factorial design with two levels was conducted to screen the main factors affecting TSC. Two main factors as extraction temperature and time were determined. Response Surface Methodology with central composite design was used to study simultaneous effects of these factors on TSC. Results showed that the optimum conditions were 54.9 °C and 80.8 min. The extract under these conditions was tested with bioactivities. The extract had the haemolytic index of 256.74 mL, anti‐inflammatory activity with IC20 of 0.56 μg/mL, anti‐oxidation activity with IC50 values of DPPH, ABTS, and hydroxyl of 61.47, 1.42, and 30.33 μg/mL, respectively, and cytotoxicity on cancer cell line HepG2. Accordingly, triterpenoid saponins from Pseuderanthemum palatiferum (Nees) Radlk. could be considered as a valuable constituent.
Kinetics of Thermal Degradation of Non‐Woven Plastics: Model‐Free Kinetic Approach
Authors: Patnaik Satyanarayan , Kumar Sachin , Panda Achyut K. 
Published: July 2019

AbstractThe thermo‐degradative behaviour of non‐woven plastics was studied in order to analyze their thermal stability and subsequent recycling method. Non‐isothermal thermogravimetric experiments using wide range of heating rates of 10, 20, 40, 60, 80,100 °Cmin−1 have been performed from ambient to 900 °C in a thermo‐balance with the objective of determining the kinetic parameters. Four model free kinetic approaches such as Friedman method, Coats‐Redfern (modified) method, Flynn–Wall–Ozawa (FWO) method and Kissinger method have been used to determine kinetic parameters for the two stage degradation of the non‐woven plastic sample including the thermal degradation of synthetic plastics in the first step followed by the subsequent degradation of inorganic fillers in the second step. The activation energy obtained for first stage degradation is found significantly lower (106‐112 kJ/mol) compared to the second stage degradation (191‐202 kJ/mol). This result would help design a process for the valorisation of synthetic polymer and segregation of the filler materials in the plastic sample to be reused further.
The Role of Polyaniline Molecular Structure in Producing High‐Performance Fe‐N‐C Catalysts for Oxygen Reduction Reaction
Authors: He Qian , Chen Xiuhong , Jia Fengqiu , Ding Wei , Zhou Yuanyuan , Wang Jian , Song Xiaoyun , Jiang Jinxia , Liao Qiang , Li Jing , Wei Zidong 
Published: July 2019

AbstractThe precise control of nano‐structure and increase active sites density are of crucial importance for the pyrolyzed Fe‐N−C catalysts′ performance optimization. Herein, the relationship between molecular structures of PANI precursors and the activity for oxygen reduction reaction (ORR) of the derived Fe‐N−C catalysts is investigated. The PANI molecular structure, especially the content of quinoid rings (QR), is controlled by varying molar ratios of ammonium persulfate (APS) to aniline monomers (AN). With the increase of APS/AN ratio from 0.5 to 4, the oxidation degree together with the QR content of PANI increases. Accordingly, the produced catalysts’ morphology experiences an evolution from bulk, nanotube to flower‐like structure. And the ORR activity shows volcano‐relationship with the increase of the QR content in PANI precursors. Specifically, when APS/AN=2.5, the derived PANI with moderate QR content benefits to produce Fe‐N−C catalyst which shows the maximum ORR activity with a half‐wave potential of 0.74 V (vs RHE) in acidic electrolyte among the produced catalysts. Moreover, two opposite effects with the increasing QR content are revealed; i) the QR benefits the Fe coordination and Fe−Nx active sites formation which enhances the activity, and ii) the accompanying formed oligomers decrease the thermal stability and thus decrease the number of active sites.
Unravelling the Dynamic Capture of Antibiotics by Conjugated Microporous Polymers
Authors: Li Li , Ge Lei , Chen Shiqian , Yuan Hao , Min Yuxiang , Xu Lai 
Published: July 2019

AbstractThe encapsulation of antibiotic molecules in conjugated microporous polymers is investigated by using the density functional theory (DFT) method and molecular dynamics (MD) simulations. We find that guest molecules are firstly wrapped around the edges of the polymer nanopores, and as the number of guest molecules increases, they begin to move from the edge to the center of the pore to further stabilize the complex. We discover a parallel sandwich‐type encapsulation model, it is the most stable configuration in which the guest molecules reside in the host framework, and the pore size of the host framework also changes with the entry of guest molecules. The significantly strong adsorption of antibiotics to CMP can be ascribed to charge transfer between the electron‐rich groups and electron‐withdrawing groups. These detailed insights would promote the design of new conjugated microporous polymers for the adsorption of antibiotics, which may provide new opportunities for the treatment of water pollution caused by antibiotics.
Study on Profile Control and Water Shut‐Off Performance of Interpenetrating Network Polymer Gel Composite System in Shallow Low Temperature Fractured Oil Layer
Authors: Fang Yujia , Yang Erlong , Cui Xiaona 
Published: July 2019

AbstractIn order to solve the problem/address the issue of oil saturation reduction in the near‐wellbore region of low‐temperature fractured reservoir in Fuyu oilfield, it is especially necessary to carry out in‐depth profile control plugging technology research. In this paper, composite system of particle plugging agent and new interpenetrating network gel were optimally designed, and the non‐fractured cores and fractured cores were used for plugging experiment and oil displacement, the in‐depth profile control mechanism of the composite system was obtained. The results show that the gelation time of the new interpenetrating network gel system can reach 6–7 hours under low temperature conditions (30 °C), with strong shear resistance and viscosity retention. The waterflooding efficiency of fractured core is lower than that of non‐fractured core. After injection of different profile control system, improved recovery efficiency of fractured core is larger than that of non‐fractured core, but the ultimate oil recovery of fractured core is still smaller than that of non‐fractured core. The gelation effect and strength of the composite system are better than that of new interpenetrating network gel agent. The addition of the expanded particles in the system greatly enhances the overall strength and anti‐interference ability. This study can provide theoretical guidance for in‐depth profile control of low temperature fractured reservoirs.