bluuebunny/crossref_metadata_2025_split huggingface dataset:
The unique nested geneALZASas a potential source of Aβ-peptides in Alzheimer’s disease
Authors: Gano Christin , Reichmann Heinz , Janetzky Bernd 
Published: October 2018

AbstractAmyloid-beta (Aβ) peptides are considered to be the cause of neuronal and synaptic cell death in Alzheimer’s disease (AD) since approximately 100 years. To date, it is assumed that Aβ-peptides arise from the proteolytic cleavage of the amyloid precursor protein (APP). However, within theAPPgene, a nested gene called ALZheimer ASsociated (ALZAS) exists, which includes the entire Aβ42-sequence and thus may also be the origin of various Aβ-species. Here, we firstly confirmed expression and the postulated amino acid sequence of ALZAS and revealed the binding of selected monoclonal Aβ-antibodies to Aβ- and ALZAS protein. We confirmed the specificity of the anti-ALZAS antibody to ALZAS by protein sequence analysis. This anti-ALZAS antibody detects the same amino acid sequence as the autoantibody found in human blood of AD patients. Since no detailed data are currently available concerningALZASexpression and the amount, localization and function of ALZAS protein in human cells and tissue, we performed gene (over)expression experiments on transcriptional and translational level. We verified a considerably lower mRNA amount ofALZAScompared to the host geneAPP. Nevertheless,ALZAStranscription and translation seems to be heavily regulated in different human tissues and cells. Artificially increased mRNA levels ofALZASdid not led to an enhanced protein amount or considerable increase in cell death. Notably, cell localization of the ALZAS protein showed accordance to endosomes indicating that ALZAS, which contains the whole transmembrane domain of APP, might be a peripheral membrane protein. Since endosome dysfunctions are a characteristic event in early stages of AD and the highest ALZAS-autoantibody levels were already detected in early AD stages,ALZASmight play a crucial role in AD pathology and could possibly be a further diagnostic marker.
Effect of soybean roasting on soymilk sensory properties
Authors: Navicha Willard , Hua Yufei , Masamba Kingsley George , Kong Xiangzhen , Zhang Caimeng 
Published: October 2018

PurposeThe purpose of this paper is to evaluate the changes in descriptive sensory properties and overall consumer acceptability of soymilk prepared from roasted soybeans.Design/methodology/approachIn total, 12 purposively selected post graduate students majoring in Food Science conducted descriptive sensory analysis after being trained for 18 h in sensory analysis, while 75 untrained students conducted consumer acceptability test of soymilk prepared by roasting soybeans at a temperature of 110°C for 20, 40, 60, 80 and 100 min and at 120°C for 20 min.FindingsResults have revealed that roasting soybeans improved sensory properties by significantly (p<0.05) decreasing the objectionable green, beany flavours and increasing sweet taste, viscosity and roasted flavour. Furthermore, results from the principal component analysis revealed that aroma and sweet taste were the most critical sensory attributes. In addition, it was found out that soymilk samples prepared by roasting soybeans at 110°C for 40 and 60 min and at 120°C for 20 min were significantly more acceptable than the control soymilk.Research limitations/implicationsThe participants in this study were from one locality and predominantly soybean consuming community and therefore there is need to conduct the study in a different locality in order to validate the study findings.Practical implicationsThe study can assist small scale processors that might not have access to lipoxygenase-free soybeans and other technologies for improving the quality of soymilk.Social implicationsThe study can be used as a guide for connecting the food processers with the external world of consumption.Originality/valueFor the first time, the study findings have demonstrated that controlled soybean roasting can be a useful strategy for improving soymilk sensory properties and consumer acceptability. The findings in this study can be usefully used in the quality control of soy bean-based products.
Research output of librarians in the field of library and information science in Nigeria: a bibliometric analysis from 2000-March, 2018
Authors: Okeji Chukwuma Clement 
Published: October 2018

PurposeThe purpose of this study is to analyze the growth of academic librarians’ research output in Nigeria; it examined their research productivity and determined the authorship pattern and degree of collaboration.

Design/methodology/approachA total of 1,106 articles were retrieved from Current index to Journals in Education and Library, Information Science and Technology Abstract databases for the period 2000-March 2018.

FindingsThe study revealed that only few authors are productive in the field of Library and Information Science in Nigeria during the period under study. The author productivity pattern is, therefore, in agreement with Lotka’s Law of inverse square. Top journals in which the academic librarians in Nigeria publish their works were identified. Of the 153 recognized universities in Nigeria, the study revealed that only few universities are productive. The years 2011 and 2012 recorded the highest contributions by the academic librarians. The findings also showed a high level of teamwork with most publications being produced jointly.

Research limitations/implicationsThe limitation of this study is that it only retrieved articles that were indexed by Current index to Journals in Education and Library, Information Science and Technology Abstract. Secondly, articles published by the academic librarians in local journals in Nigeria that are not indexed and not visible are not included in the study.

Originality/valueThe findings call for researchers in developing countries to recognize that it is important to publish a substantial number of papers in journals that are indexed and are widely visible.
Collection building in academic libraries in India: status, challenges and way forward
Authors: Ansari Mehtab Alam 
Published: October 2018

PurposeThe purpose of this paper is to highlight the status and application of automated acquisition in central university libraries in north India. North India is a loosely defined region consisting of northern parts of India. Significantly, all the libraries are having very rich collections of different types of documents.Design/methodology/approachData for the present study have been collected using questionnaire. Interview and observation techniques have also been used to bring more objectivity in the present study. MS-Excel has been used for analysis of the data. Results show that varying levels of progress has been made with respect to implementation of acquisition system in the surveyed libraries.FindingsExpectations of user community have been increased manifold in the wired world. Furthermore, suggest that the staff morale is boost up in the automated environment.Research limitations/implicationsThe study covers select academic libraries of north India. Application of various features of acquisition module is examined in this paper along with the staff perspective about automation. Automation process in these university libraries has been started with the selection of different library management software package in different universities. Notably, all the prominent central universities are located in north India.Practical implicationsThe evaluation shed light on the current automation scenario in prominent academic libraries of India.Social implicationsAll the surveyed libraries must explore the fullest potentials of all the features available in the software to provide better services. This will help in heading toward and information rich society.Originality/valueThere have been a couple of studies in the past on library automation in academic libraries, but none have intended to cover collection building or acquisition activities in central university libraries of north India.
Distributed digital preservation: preserving open journal systems content in the PKP PN
Authors: Sprout Bronwen , Jordan Mark 
Published: October 2018

PurposeThis paper aims to discuss the public knowledge project (PKP) preservation network (PN), which provides free preservation services for eligible journals by collecting article content and preserving it in a network of (at the time of writing) eight “preservation nodes” using the LOCKSS system. The PKP PN was launched in June 2016.

Design/methodology/approachThis paper addresses the development and implementation of a free, distributed digital PN for open journal systems (OJS) content. It discusses challenges in developing the network, in particular relating to preserving content from a set of partners who have no formal business relationship with PKP. The paper examines data regarding journals that have opted in to the network to date and considers interface usability and other barriers facing those that have not joined.

FindingsWithin 18 months of launch, more than 600 journals had opted to be preserved in the PKP PN. Many more journals are eligible to join the network; the paper explores potential strategies to increase participation and identifies and proposes methods to overcome technical and communication barriers.

Originality/valueThis paper describes a highly collaborative, open-source preservation initiative which forms a unique part of the e-journal preservation landscape and preserves a particularly vulnerable portion of the scholarly record.
Food literacy, healthy eating barriers and household diet
Authors: Wijayaratne Sanjeewa Pradeep , Reid Mike , Westberg Kate , Worsley Anthony , Mavondo Felix 
Published: October 2018

PurposeFood literacy is an emerging concept associated with the skills, capabilities and knowledge to prepare a healthy diet and make healthy food choices. This study aims to examine how a dietary gatekeeper’s intentions to prepare a healthy diet for their family, and the subsequent satisfaction that a healthy diet is achieved, is influenced by their food literacy and by barriers to healthy eating.Design/methodology/approachA two-stage cross-sectional study was undertaken with 756 dietary gatekeepers who completed a baseline (time 1) and a three-month follow-up (time 2) questionnaire. Partial least square-structural equation modeling was used to estimate relationships between gatekeeper food literacy, their demographic characteristics, socio-cognitive factors, time 1 satisfaction with the healthiness of the household diet and intention to provide a healthy family diet. The follow-up survey assessed subsequent satisfaction with the healthiness of the household diet and barriers to achieving it.FindingsThe results highlight the significance of the dietary gatekeeper’s food literacy in overcoming barriers to healthy eating and fostering increased satisfaction with the healthiness of the family diet. The research further highlights the influence of past satisfaction, attitude, subjective norms and perceived behavioural control. Several demographics factors are also highlighted as influential.Research limitations/implicationsThe research offers new insights into the role of food literacy in the home environment including its influence on the dietary gatekeeper’s satisfaction with the family diet. The current model also provides strong evidence that food literacy can reduce the impact of barriers to healthy eating experienced by gatekeepers. The research has limitations associated with the socio-economic status of respondents and thus offers scope for research into different populations and their food literacy, younger and early formed cohabiting and the negotiation of food and dietary responsibility and on intergenerational food literacy.Practical implicationsThe current findings regarding the impact of food literacy have significant implications for government agencies, non-profit agencies, educational institutions and other related stakeholders in their effort to curb obesity. Implications exist for micro-level programmes and actions designed to influence gatekeepers, family members and households and at the macro level for policies and programmes designed to influence the obesogenicity of the food environments.Originality/valueThe current study is one of the first to offer evidence on the role of food literacy in the home environment and its ability to overcome barriers to healthy eating. The research provides social marketers and public policymakers with novel insights regarding the need for increased food literacy and for developing interventions to improve food literacy in dietary gatekeepers.
Finding desirable post-consumption behaviors
Authors: Kang Juhee 
Published: October 2018

PurposeThe purpose of this paper is to identify the antecedents and consequences of romantic brand love in the luxury hotel context.Design/methodology/approachData were collected from guests who had stayed at a luxury hotel within the past year and analyzed using structural equation modeling.FindingsThe findings indicate that uniqueness and hedonic values are a prerequisite of evoking closeness and passionate feelings toward hotel brands, resulting in guests’ advocacy and willingness to pay a premium price.Practical implicationsThis study provides practical implications for luxury hotel marketers by introducing a new angle to understand brand love and suggesting desirable post-consumption behaviors through creating romantic love relationships between guests and hotel brands.Originality/valueResearch on the multidimensional aspects of luxury value is limited. This study proposes a conceptual model to investigate which luxury values enable guests to fall in love with brands and influence future behavior decisions and identifies opportunities for managerial benefits relating to consumers who are not traditional or frequent visitors to hotels.
Health care complaint journeys for system comparison
Authors: Nagy Marie , Chiarella Mary , Bennett Belinda , Walton Merrilyn , Carney Terry 
Published: October 2018

Purpose
The “patient journey” technique is one that has been used by health care providers to investigate the strengths and weaknesses of their service delivery. The purpose of this paper is to discuss the experience of adapting this approach for use in an atypical context – the comparison of two systems for managing health care complaints and notifications. It highlights a number of relevant considerations and provides suggestions for similar studies.

Design/methodology/approach
The design and methods of the study are described, with commentary on the success of key aspects and challenges encountered. To enable comparison between the two systems, this study had a “paired” design, in which examples were selected from each system so that they matched on basic, prescribed, criteria. Data about each matter’s journey were then collected from administrative records.

Findings
While, overall, the technique provided rich data on the processes of the systems under investigation, the type of data collected (related to administrative/communicative events) and the study’s comparative purpose required consideration and management of a number of issues. These included the implications of using administrative records and the impact of differences between the systems on the paired design.

Originality/value
This paper describes an attempt to apply the “journey” approach in a context that is uncommon in two ways: first, in its focus on regulatory processes (complaint/notification handling), rather than care provision to an individual patient; and second, in its objective of comparing two different systems. It is hoped this account will assist in further development of this technique.
Registered nurses’ knowledge and care practices regarding patients with dysphagia in Saudi Arabia
Authors: Khoja Manal Abdullah 
Published: October 2018

Purpose
The purpose of this paper is to assess the knowledge and practices of nursing staff caring for patients with dysphagia to determine any needs for further education programmes.

Design/methodology/approach
A self-administered questionnaire with close-ended questions was completed by nurses at a tertiary hospital in Saudi Arabia to measure the depth of their dysphagia knowledge.

Findings
From 316 potential participants, a sample of 174 nurses completed the questionnaire. The results revealed that the participants had partial theoretical and practical knowledge about nursing care for patients with dysphagia. Of interest, 78 per cent of the nurses reported that they had received less than 1 h of training in dysphagia, and only 4 per cent were aware of speech and language pathologists’ role in dysphagia management.

Practical implications
As the medical professionals who have the most contact with the patients, nurses have a central role in the care of patients with dysphagia. This study provides information that will guide strategies for in-service nurse education dysphagia programmes.

Originality/value
The estimated Saudi prevalence of dysphagia is high due to increased incidence of medical conditions commonly associated with dysphagia, such as stroke, cerebral palsy and traumatic brain injuries from traffic accidents. Nurses play a pivotal role in caring for these patients. However, little is known about the level of care patients with dysphagia require in Saudi hospital settings.
Intravenous fluid delivery time improvement: application of cross-docking system
Authors: Khorasani Sasan T. , Keshtzari Maryam , Islam Md Saiful , Feizi Ramyar 
Published: October 2018

Purpose
The cost of pharmaceutical supply chain due to drug waste is one of the current major issues in health care. Drug waste associated with intravenous (IV) fluid form of medication is one of the crucial issues for many pharmacies. The purpose of this paper is to apply a cross-docking model to minimize the IV delivery lead time to reduce drug waste by scheduling staff in a local hospital’s inpatient pharmacy.

Design/methodology/approach
A mixed integer linear programming model is applied to the IV delivery system of a hospital. The parameters are selected based on the observations made in the inpatient pharmacy.

Findings
The result implies that cross-docking approach can be effectively applied to IV delivery system. In fact, the cross-docking optimization model employed in this case study reduces the IV delivery completion time of the inpatient pharmacy by 41 percent.

Research limitations/implications
The scope of this research is limited to the activities performed after IV preparation.

Practical implications
The application of cross-docking system in staff scheduling will be beneficial for health care organizations that aim to minimize medication waste.

Originality/value
The prime value of this study lies in the introduction of a cross-docking concept in an internal hospital ordering process. Cross-docking models are widely used in general supply chain systems; however, their application for specific activities inside hospitals is the novelty of this study, which can fill the research gap in terms of drug waste management within the inpatient pharmacy.
Environmental impact reduction as a new dimension for quality measurement of healthcare services
Authors: Esmaeili Amin , McGuire Charles , Overcash Michael , Ali Kamran , Soltani Seyed , Twomey Janet 
Published: October 2018

Purpose
The purpose of this paper is to provide a detailed accounting of energy and materials consumed during magnetic resonance imaging (MRI).

Design/methodology/approach
The first and second stages of ISO standard (ISO 14040:2006 and ISO 14044:2006) were followed to develop life cycle inventory (LCI). The LCI data collection took the form of observations, time studies, real-time metered power consumption, review of imaging department scheduling records and review of technical manuals and literature.

Findings
The carbon footprint of the entire MRI service on a per-patient basis was measured at 22.4 kg CO2eq. The in-hospital energy use (process energy) for performing MRI is 29 kWh per patient for the MRI machine, ancillary devices and light fixtures, while the out-of-hospital energy consumption is approximately 260 percent greater than the process energy, measured at 75 kWh per patient related to fuel for generation and transmission of electricity for the hospital, plus energy to manufacture disposable, consumable and reusable products. The actual MRI and standby energy that produces the MRI images is only about 38 percent of the total life cycle energy.

Research limitations/implications
The focus on methods and proof-of-concept meant that only one facility and one type of imaging device technology were used to reach the conclusions. Based on the similar studies related to other imaging devices, the provided transparent data can be generalized to other healthcare facilities with few adjustments to utilization ratios, the share of the exam types, and the standby power of the facilities’ imaging devices.

Practical implications
The transparent detailed life cycle approach allows the data from this study to be used by healthcare administrators to explore the hidden public health impact of the radiology department and to set goals for carbon footprint reductions of healthcare organizations by focusing on alternative imaging modalities. Moreover, the presented approach in quantifying healthcare services’ environmental impact can be replicated to provide measurable data on departmental quality improvement initiatives and to be used in hospitals’ quality management systems.

Originality/value
No other research has been published on the life cycle assessment of MRI. The share of outside hospital indirect environmental impact of MRI services is a previously undocumented impact of the physician’s order for an internal image.