bluuebunny/crossref_metadata_2025_split huggingface dataset:
Brief Educational Intervention Improves Emergency Medical Services Stroke Recognition
Authors: Oostema J. Adam , Chassee Todd , Baer William , Edberg Allison , Reeves Mathew J. 
Published: March 2019

Background and Purpose—
Recognition of stroke symptoms and hospital prenotification by emergency medical services (EMS) facilitate rapid stroke treatment; however, one-third of patients with stroke are unrecognized by EMS. To promote stroke recognition and quality measure compliant prehospital stroke care, we deployed a 30-minute online EMS educational module coupled with a performance feedback system in a single Michigan county.

Methods—
During a 24-month study period, a registry of consecutive EMS-transported suspected or unrecognized stroke cases was utilized to perform an interrupted time series analysis of the impact of the EMS education and feedback intervention. For each agency, we compared EMS stroke recognition and quality measure compliance rates, as well as emergency department performance and hospital outcomes during 12 preintervention months with performance in the remaining study months.

Results—

A total of 1805 EMS-transported cases met inclusion criteria; 1235 (68.4%) of these had ischemic or hemorrhagic strokes or transient ischemic attacks. There were no trends toward improvement in any outcome before the intervention. After the intervention, the EMS stroke recognition rate increased from 63.8% to 69.5% (
P
=0.037). Prenotification increased from 60.9% to 77.3% (
P
<0.001). Among patients with ischemic stroke/transient ischemic attack, there was a trend toward higher rates of tPA (tissue-type plasminogen activator) delivery (13.9%–17.7%;
P
=0.096) and a significant increase in tPA delivery within 45 minutes (5.7%–8.9%;
P
=0.042) after intervention. However, improvements in EMS recognition were limited to the first 3 months following intervention.

Conclusions—
A brief educational intervention was associated with improved EMS stroke recognition, hospital prenotification, and faster tPA delivery. Gains were primarily observed immediately following education and were not sustained through provision of performance feedback to paramedics.
The Study of Involuntary Migration as a Hermeneutical Guide for Reading the Jacob Narrative
Authors: Strine C.A. 
Published: March 2019

AbstractThe patriarch Jacob is an involuntary migrant. Jacob lives as an asylum seeker from Esau’s threat of violence and then as a refugee under Laban’s protection. Eventually, Jacob returns ‘home’ to Canaan, but he finds there a society totally different than the one he remembers or imagines. Jacob resembles involuntary migrants from other cultures in all of these ways. The experiences of other involuntary migrants can and should, therefore, guide interpretation of this narrative. This article, therefore, exegetes the texts concerning Jacob in Genesis 25-33 by utilising findings from the social-scientific study of involuntary migration, James C. Scott’s work on subaltern resistance, and studies on the role of trickster narratives in the Hebrew Bible. By generating new interpretive solutions to perennially problematic passages and showing the prominence of the experience of involuntary migration in Genesis, this article outlines an important new hermeneutical approach relevant not only for this text but also for a large number of texts in the Hebrew Bible concerned with involuntary migration.
Undue Intrusion on Parties’ Autonomy Finally Amended: An Observation of Article 51 of the Jordanian Arbitration Law
Authors: Al-Hawamdeh Ahmed Mohammad , Alhusban Ahmad Abed Alla 
Published: March 2019

Abstract
Before its amendment in 2018, Article 51 of the Jordanian Arbitration Law stated that: ‘if the court nullifies the award, consequently it would render the arbitration agreement nullified’. The newly amendment Article 51 of the Jordanian Arbitration Law reads: ‘If the Court of Cassation […] nullifies the award that should not result in nullifying the arbitration clause unless the arbitration agreement is itself void’. Here we argue that the new amendment was long due as the previous Article unduly intruded on parties’ autonomy. This article was originally submitted before the 2018 amendment of the law and the exact wording of what the article originally suggested was adopted by the new law.
Deciphering Egyptian Rap Ciphers
Authors: Mangialardi Nicholas 
Published: March 2019

Abstract
In this essay, I look at hip hop music in Egypt and examine a popular rap activity known as ‘ciphering’, a verbal jam session in which rappers take turns trading lyrics over a beat. The gatherings I investigate were usually held on public city sidewalks, but Egyptian youth also exchanged short rap videos online with friends in what became a virtual cipher. Through these rap ciphers, Egyptian youth established creative spaces outside the realm of family authority where they could rehearse different selves among friends. The technologies with which they recorded and traded their videos were key to the social experience of ciphering and offered new ways of narrating the self. In this essay, I suggest that ciphering entails more than just rapping; it is a practice entangled in a range of social activities that Egyptian youth do together. Through the ritual of ciphering, rappers affirm their individuality and establish membership in groups.
China, the Abode of Arts and Crafts: Emergence and Diffusion of a Persian Saying on China in Mongol Eurasia
Authors: Calzolaio Francesco 
Published: March 2019

AbstractBetween 1250 and 1450 a saying about China spread across Eurasia, from Castile to the Indian subcontinent. It is the proverb known as the “eyes of the world”, according to which when it comes to arts and crafts, the Chinese see with two eyes, the Europeans with one, and other nations are blind. This metaphor was widely used by pre-modern Eurasian intellectuals to synthesize the high degree of sophistication and splendour reached by Chinese culture. It has been suggested that the adage originated either in the Byzantine world or in Mongol China, whence it spread to central Asia, the Indian subcontinent, and Europe. A study of Persian sources, however, seems to invalidate this hypothesis, suggesting a Persian origin. Such Eurasian diffusion of a Persian saying about China illustrates how easily literary images, tropes, and lore could spread across the Mongol empire and how Asian geographic and ethnographic discourses could contribute to the new representation of the world which emerged in the Mongol period. It also advocates for the inclusivity of Persian literary imagery, at times so influent as to trespass the borders both of the Persianate and of the Islamicate world.
Horner Syndrome Secondary to Metastatic Squamous Cell Carcinoma in the Neck: A Case Series
Authors: Lele Saudamini , Derise Natalie , Medlin Tara , Takalkar Amol , Nathan Cherie-Ann 
Published: March 2019

Background: Horner syndrome caused by metastatic squamous cell carcinoma of the head and neck is not common, and when diagnosed, may have serious clinical implications. We aim at highlighting the clinical significance of this finding. Methods: We retrospectively reviewed charts of 6 patients with Horner syndrome secondary to metastatic head and neck squamous cell carcinoma (HNSCC) in the neck. Results: All 6 patients had pathologically confirmed nodal metastatic HNSCC. There was one unknown primary and in the remaining 5 patients the primary tumor was identified in the oropharynx, larynx, and oral cavity. Three patients died within 1 month of diagnosis, before initiation of any treatment. One patient received radiation only while 2 patients received chemoradiation with cisplatin as the tumors were unresectable given carotid sheath involvement. Median survival was 4.5 months. Only 1 out of the 6 patients survived and had complete resolution of Horner syndrome after treatment. Conclusion: This is the first case series of neck metastasis from mucosal HNSCC as an unusual cause of Horner syndrome and is usually associated with very poor prognosis.
Development of a Biosecurity Checklist for Laboratory Assessment and Monitoring
Authors: Brizee Sabrina , Passel Mark W. J. van , Berg Linda M. van den , Feakes Daniel , Izar Ana , Lin Kathryn Tham Bee , Podin Yuwana , Yunus Zalini , Bleijs Diederik A. 
Published: March 2019

Introduction: Laboratory biosecurity is of continuously growing interest due to increasing concerns about deliberate misuse of biological materials and emerging biological risks. These risks continue to be magnified by globalization, the rapid pace of scientific development, and dual-use technologies. Worldwide laboratory capacities are expanding, which calls for concrete actions to improve laboratory biosafety and biosecurity practices to protect researchers and the community. Hence, laboratories require comprehensive biorisk management programs to minimize the risk of accidental and deliberate release of infectious biological materials. Objective: Malaysia has prioritized the concern of national biosecurity and aims to consolidate laboratory biosecurity performance to detect and prevent the deliberate release of biological agents. Methods: Two 3-day workshops were organized over the course of four months in which Malaysia collaborated with The Netherlands. This bilateral engagement aimed to integrate biosecurity practices in their national biorisk management programs, and resulted into a comprehensive biosecurity checklist for laboratory assessment and monitoring. Results: This biosecurity checklist is based on Malaysian and Dutch expert opinions and national and international guidelines and regulations. The biosecurity checklist is a survey-driven tool that consists of a set of concrete questions for each key biosecurity area, which are discussion points for assessment. Conclusion: We display a practical biosecurity checklist for laboratory assessment and monitoring. Although the presented checklist was the template for the specific Malaysia checklist, it could serve as a template for other countries.
EFFECTIVENESS OF HIGH SCHOOL GIRLS LACROSSE HEADGEAR MANDATE IN THE REDUCTION OF HEAD AND FACE INJURIES
Authors: Veasley Shayla , Baron Samuel L. , Nguyen Michael , Anil Utkarsh , Alaia Michael , Cardone Dennis , Testa Noel 
Published: March 2019

INTRODUCTION: Due to a large number of eye injuries in girls’ lacrosse, US Lacrosse instituted a rule making protective eye-wear mandatory starting in the 2004-2005 season. Although the eye-wear was shown to significantly reduce injuries to the eyes, injuries to the head and face are still commonly reported despite body checks and stick checks to the body being illegal. In 2016, US lacrosse ruled that headgear could be used by its teams as long as it meets ASTM standard F3137*. There has been continued controversy over whether or not headgear in women’s lacrosse could make players more aggressive and/or lead to fewer dangerous call penalties by the officials, thus increasing the head and face injury rate. In 2017, the Public Schools Athletic League, which governs most scholastic sports in New York City, became the first high school organization in the country to mandate ASTM standard F3137 headgear for all women’s lacrosse players. The purpose of this study is to investigate the effect of ASTM standard F3137 approved headgear on the rate of head and face injuries in high school girls’ lacrosse. METHODS: This was a prospective cohort study. The study group included three JV and five varsity girls’ lacrosse teams, as well as their game opponents, who were mandated to wear headgear for all practice and game events over the course of the 2016-2017 and 2017-2018 lacrosse seasons. Certified athletic trainers assessed and documented all injuries that occurred as a result of participation on the lacrosse teams and athlete exposures were estimated based on the number of team practice and game events. Injury rates were compared with those from the High School RIO (Reporting Information Online) injury data reports from the 2008-2009 to 2015-2016 lacrosse seasons as well as an external publication based on RIO data that provided concussion injury rates. RESULTS: Over the study period, 17 total injuries were reported during 22397 athlete exposures (AEs), for an injury rate of 0.76 injuries per 1000 AEs. Two total head/face injuries (2 concussions) were reported during the study for both a head/face and concussion rate of 0.09 per 1000 AEs. There was a significant decrease in injury rates for total injuries (RR 0.4927; 95% Confidence Interval [CI], 0.3037-0.7995; P-value 0.004) and head/face injuries (RR 0.2232; 95% CI, 0.2232-0.055; p-value 0.016) when comparing this data to the HS RIO study reports. When compared to the concussion data provided by the external RIO publication, there was a lower injury rate that was not found to be significant (RR 0.26; 95% CI, 0.0630 -1.033; p-value: 0.03879). DISCUSSION AND CONCLUSION: Headgear use did not increase the injury rate for the head/face when compared to data before the optional headgear use rule. This may help to dispel fears over an injury rate that would increase due to more aggressive play or less cautious officiating.
How I manage anticoagulant therapy in older individuals with atrial fibrillation or venous thromboembolism
Authors: Chan Noel C. , Eikelboom John W. 
Published: March 2019

Abstract
Anticoagulant therapy is the most effective strategy to prevent arterial and venous thromboembolism, but treating older individuals is challenging, because increasing age, comorbidities, and polypharmacy increase the risk of both thrombosis and bleeding. Warfarin and non–vitamin K antagonist oral anticoagulants are underused and often underdosed in the prevention of stroke in older patients with atrial fibrillation because of concerns about the risk of bleeding. Poor adherence to anticoagulant therapy is also an issue for older patients with atrial fibrillation and those at risk of recurrent pulmonary embolism. In this review, we present 5 clinical cases to illustrate common challenges with anticoagulant use in older patients and discuss our approach to institute safe and effective antithrombotic therapy.
Leukemoid reaction in chronic myelomonocytic leukemia patients undergoing surgery: perioperative management recommendations
Authors: Patel Ami B. , Pettijohn Erin M. , Abedin Sameem M. , Raps Evan , Deininger Michael W. 
Published: March 2019

Key Points
CMML patients comprise an elderly and frail patient population with comorbidities that often require surgical intervention. Postsurgical leukemoid reaction, a life-threatening complication in CMML patients, may be driven by molecular mechanisms.
Predictive and prognostic value of ZEB1 protein expression in breast cancer patients with neoadjuvant chemotherapy
Authors: Wu Ziping , Zhang Lei , Xu Shuguang , Lin Yanping , Yin Wenjin , Lu Jinglu , Sha Rui , Sheng Xiaonan , Zhou Liheng , Lu Jinsong 
Published: March 2019

Abstract
Background
Zinc finger E-box binding homeobox 1 (ZEB1) is a molecule involved in the progression of epithelial-to-mesenchymal transition (EMT) in various kinds of cancers. Here, we aimed to determine whether the expression of the ZEB1 protein is related to the response of patients to neoadjuvant therapy as well as their survival outcome.

Methods
Immunohistochemistry (IHC) was performed on paraffin-embedded tumor samples from core needle biopsy before neoadjuvant therapy (NAT). Univariate and multivariate logistic regression analyses were used to analyze the associations between the protein expression of ZEB1 and the pathological complete response (pCR) outcome. Kaplan–Meier plots and log-rank tests were used to compare disease-free survival (DFS) between groups. A Cox proportional hazards model was used to calculate the adjusted hazard ratio (HR) with a 95% confidential interval (95% CI).

Results
A total of 75 patients were included in the IHC test. High ZEB1 protein expression was associated with a low pCR rate in both univariate (OR = 0.260, 95% CI 0.082–0.829, p = 0.023) and multivariate (OR = 0.074, 95% CI 0.011–0.475, p = 0.006) logistic regression analyses. High ZEB1 protein expression was also associated with a short DFS according to both the log-rank test (p = 0.023) and Cox proportional hazard model (HR = 9.025, 95% CI 1.024–79.519, p = 0.048). In hormone receptor positive (HorR-positive) patients, high ZEB1 protein expression was also associated with a lower pCR (OR = 0.054, 95% CI 0.007–0.422, p = 0.005) and a poorer DFS (HR = 10.516, 95% CI 1.171–94.435, p = 0.036) compared with low ZEB1 protein expression. In HER2-overexpressing patients, ZEB1 protein expression was also associated with poor survival (p = 0.042).

Conclusions
Our results showed that high ZEB1 protein expression was a negative predictive marker of pCR and DFS in neoadjuvant therapy in breast cancer patients and in HorR-positive and HER2-overexpressing subgroups.
Trial registration NCT, NCT02199418. Registered 24 July 2014—Retrospectively registered, https://clinicaltrials.gov/ct2/show/NCT02199418?term=NCT02199418&rank=1. NCT, NCT 02221999. Registered 21 August 2014—Retrospectively registered, https://clinicaltrials.gov/ct2/show/NCT02221999?term=NCT02221999&rank=1
Duplication of uniqueness: electrotyping in nature printing and its application in contemporary art
Authors: Ljubić Tobisch Valentina , Selimović Albina , Artaker Anna , Klobassa Martin , Kautek Wolfgang 
Published: March 2019

Abstract
The nature printing technique was designed for the electrotyping reproduction of leaves and other natural products. Authentic impressions could be performed by inserting leaves between two lead plates or pressing leaves into the lead plate by a press. The impression obtained in the soft lead plate could then be further reproduced by copper electroplating. Electrochemically deposited copper is hard-wearing and therefore very suitable for the production of printing plates. However, depending on the technical implementation and the choice of the materials used, decisive differences in the faithfulness of reproductions of original motifs may occur during the electrochemical deposition. A central topic in electroforming of printing plates is the choice of the conductive layer on the mould. In the present study, it has been shown that graphite powder represents a conductive phase on the siloxane mould superior to silver and copper powder. The grain size of the copper electrodeposit depended on the powder grain size. The copper plate deposited on graphite powder showed the lowest grain size (5–20 µm) and the highest homogeneity of the print background. Hand polishing of the printing plate resulted in a much better faithfulness of the motif details than that of the machine polished version. However, the background of the print derived from the machine polished plate was the most homogeneous. Electrochemical investigation showed that remnants of the silver powder could result in local elements that could enhance corrosion and thus impair the durability of the printing plates. This phenomenon was negligible with the conductive layers consisting of graphite and copper.
A new prototype melt-electrospinning device for the production of biobased thermoplastic sub-microfibers and nanofibers
Authors: Koenig Kylie , Beukenberg Konrad , Langensiepen Fabian , Seide Gunnar 
Published: March 2019

Abstract

Sub-microfibers and nanofibers have a high surface-to-volume ratio, which makes them suitable for diverse applications including environmental remediation and filtration, energy production and storage, electronic and optical sensors, tissue engineering, and drug delivery. However, the use of such materials is limited by the low throughput of established manufacturing technologies. This short report provides an overview of current production methods for sub-microfibers and nanofibers and then introduces a new melt-electrospinning prototype based on a spinneret with 600 nozzles, thereby providing an important step towards larger-scale production. The prototype features an innovative collector that achieves the optimal spreading of the fiber due to its uneven surface, as well as a polymer inlet that ensures even polymer distribution to all nozzles. We prepared a first generation of biobased fibers with diameters ranging from 1.000 to 7.000 μm using polylactic acid and 6% (
w
/w) sodium stearate, but finer fibers could be produced in the future by optimizing the prototype and the composition of the raw materials. Melt electrospinning using the new prototype is a promising method for the production of high-quality sub-microfibers and nanofibers.
Harnessing Clinical Sequencing Data for Survival Stratification of Patients With Metastatic Lung Adenocarcinomas
Authors: Shen Ronglai , Martin Axel , Ni Ai , Hellmann Matthew , Arbour Kathryn C. , Jordan Emmet , Arora Arshi , Ptashkin Ryan , Zehir Ahmet , Kris Mark G. , Rudin Charles M. , Berger Michael F. , Solit David B. , Seshan Venkatraman E. , Arcila Maria , Ladanyi Marc , Riely Gregory J. 
Published: March 2019

PURPOSE Broad-panel sequencing of tumors facilitates routine care of people with cancer as well as clinical trial matching for novel genome-directed therapies. We sought to extend the use of broad-panel sequencing results to survival stratification and clinical outcome prediction. METHODS By using sequencing results from a cohort of 1,054 patients with advanced lung adenocarcinomas, we developed OncoCast, a machine learning tool for survival risk stratification and biomarker identification. RESULTS With OncoCast, we stratified this patient cohort into four risk groups on the basis of tumor genomic profile. Patients whose tumors harbored a high-risk profile had a median survival of 7.3 months (95% CI, 5.5 to 10.9 months) compared with a low-risk group with a median survival of 32.8 months (95% CI, 26.3 to 38.5 months) with a hazard ratio of 4.6 ( P < .001), far superior to any individual gene predictor or standard clinical characteristics. We found that comutations of both STK11 and KEAP1 are strong determinants of unfavorable prognosis with currently available therapies. In patients with targetable oncogenes (eg, EGFR, ALK, ROS1) who received targeted therapies, the tumor genetic background additionally differentiated survival with mutations in TP53 and ARID1A, which contributed to a higher risk score for shorter survival. CONCLUSION A mutational profile derived from broad-panel sequencing presents an effective genomic stratification for patient survival in advanced lung adenocarcinoma. OncoCast is available as a public resource that facilitates the incorporation of mutational data to predict individual patient prognosis and compare risk characteristics of patient populations.