bluuebunny/crossref_metadata_2025_split huggingface dataset:
Diagnostic and classification tools for chronic headache disorders: A systematic review
Authors: Potter Rachel , Probyn Katrin , Bernstein Celia , Pincus Tamar , Underwood Martin , Matharu Manjit 
Published: October 2018

Background or aim Despite guidelines and the International Classification of Headache Disorders (ICHD-III beta) criteria, the diagnosis of common chronic headache disorders can be challenging for non-expert clinicians. The aim of the review was to identify headache classification tools that could be used by a non-expert clinician to classify common chronic disorders in primary care. Methods We conducted a systematic literature review of studies validating diagnostic and classification headache tools published between Jan 1988 and June 2016 from key databases: MEDLINE, ASSIA, Embase, Web of Knowledge and PsycINFO. Quality assessment was assessed using items of the Quality of Diagnostic Accuracy Studies (QUADAS-2). Results The search identified 38 papers reporting the validation of 30 tools designed to diagnose, classify or screen for headache disorders; nine for multiple headache types, and 21 for one headache type only. We did not identify a tool validated in a primary care that can be used by a non-expert clinician to classify common chronic headache disorders and screen for primary headaches other than migraine and tension-type headache in primary care. Conclusions Despite the availability of many headache classification tools we propose the need for a tool that could support primary care clinicians in diagnosing and managing chronic headache disorders within primary care, and allow more targeted referral to headache specialists.
Collagen triple helix repeat containing-1: a novel biomarker associated with disease activity in Systemic lupus erythematosus
Authors: Wu Q , Yang Q , Sun H 
Published: October 2018

Objective The objective of this article is to investigate whether the aberrant expression of collagen triple helix repeat containing-1 (CTHRC1) from patients with systemic lupus erythematosus (SLE) could contribute to the pathogenesis of lupus. Methods We divided SLE patients into active groups (Systemic Lupus Erythematosus Disease Activity Index (SLEDAI) score ≥ 6) and inactive groups (SLEDAI score < 6). Serum concentrations of CTHRC1, interferon alpha, interleukin (IL)-28A and IL-28B were determined using an enzyme-linked immunosorbent assay in a group of 40 patients with SLE. Results were compared with those from 23 healthy controls. Results Serum CTHRC1 protein levels were higher in patients with SLE compared with healthy controls. Patients with active disease displayed higher CTHRC1 levels compared with those with inactive disease as well. There was a positive association between serum CTHRC1 levels and SLEDAI and erythrocyte sedimentation rate, and a negative correlation with complement 3 and 4. Moreover, serum CTHRC1 levels were higher in SLE patients with arthritis and anemia compared with patients without the above-mentioned manifestations. Conclusions These findings indicate CTHRC1 probably plays an important part in the pathogenesis of SLE, and is positively associated with disease activity, while it also likely refers to the development of arthritis and anemia in SLE. Therefore, CTHRC1 may provide a novel research target and shed new light on the pathogenesis and therapy of SLE.
Lifestyle changes associated with participation in colorectal cancer screening: Prospective data from the English Longitudinal Study of Ageing
Authors: Stevens Claire , Smith Samuel G , Vrinten Charlotte , Waller Jo , Beeken Rebecca J 
Published: October 2018

Objectives Population-based cancer screening has been described as a teachable moment for behaviour change. This research examined the effect of faecal occult blood testing (FOBT) participation on smoking, alcohol consumption, fruit and vegetable consumption and physical activity. Setting Data were from screening-naïve men within the English Longitudinal Study of Ageing, receiving their first FOBT invitation (n = 774). Four waves of data were included in analyses (wave 4, 2008/2009 – wave 7, 2014/2015). Baseline data were from the wave prior to FOBT invitation, and follow-up data were from the next consecutive wave (two years later). Methods The effects of FOBT participation, time and group-by-time interactions on health behaviours were investigated using generalised estimating equations. Almost two-thirds of the sample (62.5%; n = 484) had participated in FOBT. Results Screening participants were less likely to smoke (odds ratio (OR): 0.45, 95% confidence interval (CI): 0.29–0.68) and more likely to meet fruit and vegetable consumption guidelines (OR: 1.70, 95% CI: 1.14–2.55). Smoking decreased over time (OR: 0.74, 95% CI: 0.62–0.89), but adherence to alcohol guidelines also decreased (OR: 0.71, 95% CI: 0.53–0.91). A group-by-time interaction was found for vigorous physical activity; the odds of taking part in vigorous physical activity increased for FOBT participants, but decreased for non-participants (OR: 1.40, 95% CI: 1.01–1.95). Conclusions This research provides tentative support for FOBT as a teachable moment for increasing vigorous physical activity. However, overall, there was limited evidence for spontaneous improvement in multiple health behaviours following participation.
Prediction of Target Genes and Pathways Associated With Cetuximab Insensitivity in Colorectal Cancer
Authors: Yu Chaoran , Hong Hiju , Lu Jiaoyang , Zhao Xuan , Hu Wenjun , Zhang Sen , Zong Yaping , Mao Zhihai , Li Jianwen , Wang Mingliang , Feng Bo , Sun Jing , Zheng Minhua 
Published: October 2018

Background: Cetuximab has been regularly added to the treatments for metastatic colorectal cancer worldwide. However, due to its therapeutic insensitivity and underlying mechanisms being largely unknown, the clinical implementation of cetuximab in colorectal cancer remains limited. Methods: The gene expression profile GSE56386 was retrieved from the Gene Expression Omnibus database. Differentially expressed genes were identified between cetuximab-responsive patients and nonresponders, annotated by gene ontology, Kyoto Encyclopedia of Genes and Genomes pathway analysis, and further analyzed by protein–protein interaction networks. The integrative prognostic analysis was based on The Cancer Genome Atlas and PrognoScan. Results: 1350 differentially expressed genes were identified with 298 upregulated and 1052 downregulated. Epidermis development, the cornified envelope, calcium ion binding, and amoebiasis were enriched in upregulated genes while digestion, the apical part of the cell, the 3′,5′-cyclic-adenosine monophosphate phosphodiesterase activity and pancreatic secretion were found enriched in downregulated genes. The top 10 hub genes were identified, including epithermal growth factor, G-protein subunit β 5, G-protein subunit γ 4, fibroblast growth factor 2, B-cell lymphoma protein 2, acetyl-coenzyme A carboxylase β, KIT proto-oncogene receptor tyrosine kinase, adenylate cyclase 4, neuropeptide Y, and neurotensin. The hub genes exhibited distinct correlations in cetuximab-treated and untreated genomic profiles (GSE56386, GSE5851 and GSE82236). The highest correlation was found between B-cell lymphoma protein 2 and acetyl-coenzyme A carboxylase β in GSE56386. The mRNA expression of hub genes was further validated in the genomic profile GSE65021. Furthermore, B-cell lymphoma protein 2 and acetyl-coenzyme A carboxylase β also exhibited highest degrees among the hub genes correlation networks based on The Cancer Genome Atlas. Both B-cell lymphoma and acetyl-coenzyme A carboxylase β were not independent prognostic factors for colorectal cancer in univariate and multivariate Cox analysis. However, integrative survival analysis indicated that B-cell lymphoma protein 2 was associated with favorable prognosis (hazard ratio = 0.62, 95% confidence interval, 0.30-0.95, P = .024). Discussion: This in silico analysis provided a feasible and reliable strategy for systematic exploration of insightful target genes, pathways and mechanisms underlying the cetuximab insensitivity in colorectal cancer. B-cell lymphoma protein 2 was associated with favorable prognosis.
Experiences and decision making during paediatric transitions to continuous sub-cutaneous insulin infusion (CSII): A mixed method study
Authors: Altmann Erika , Stirling Christine , Broad Liz 
Published: October 2018

Objectives We aimed to improve the decision quality and outcomes for families with children or adolescents with diabetes considering continuous sub-cutaneous insulin infusion (CSII). Methods A mixed method study involved three focus groups with youth, parents and clinicians to provide experience information as background to the development of a decision aid (DA). A pre-test (T1) and post-test (T2) evaluation of the DA with a convenience sample of five families considering initiating CSII. Results The focus group data showed that families found the move to CSII to be generally empowering with adolescents engaging with the technology quickly, and that experiential information from others was important in the process. Participants increased their knowledge and decreased decisional conflict after using the DA from T1 to T2. Preferred option measurement indicated that at T1, three participants were ‘unsure’ and two participants’ preferred option was CSII. After exposure to the DA at T2, those who were previously unsure had a preferred option of CSII with a resulting five people with a preferred option of CSII. Conclusions The results from this study suggest that transitioning to CSII for paediatric and adolescent patients and their carers may be assisted by a DA and that participants felt empowered to a make decision regarding CSII when using the PANDANI DA. The quasi-experimental design without randomisation or control group was a study limitation caused by the small number of participants. Expanding this pilot research into a randomised control trial would decrease the threat to validity from other possible explanations for the improvement in decisional conflict, such as nurse educators.
The chemodiversity of paddy soil dissolved organic matter correlates with microbial community at continental scales
Authors: Li Hong-Yi , Wang Hang , Wang Hai-Tao , Xin Pei-Yong , Xu Xin-Hua , Ma Yun , Liu Wei-Ping , Teng Chang-Yun , Jiang Cheng-Liang , Lou Li-Ping , Arnold Wyatt , Cralle Lauren , Zhu Yong-Guan , Chu Jin-Fang , Gilbert Jack A , Zhang Zhi-Jian 
Published: October 2018

Abstract
Background
Paddy soil dissolved organic matter (DOM) represents a major hotspot for soil biogeochemistry, yet we know little about its chemodiversity let alone the microbial community that shapes it. Here, we leveraged ultrahigh-resolution mass spectrometry, amplicon, and metagenomic sequencing to characterize the molecular distribution of DOM and the taxonomic and functional microbial diversity in paddy soils across China. We hypothesized that variances in microbial community significantly associate with changes in soil DOM molecular composition.

Results
We report that both microbial and DOM profiles revealed geographic patterns that were associated with variation in mean monthly precipitation, mean annual temperature, and pH. DOM molecular diversity was significantly correlated with microbial taxonomic diversity. An increase in DOM molecules categorized as peptides, carbohydrates, and unsaturated aliphatics, and a decrease in those belonging to polyphenolics and polycyclic aromatics, significantly correlated with proportional changes in some of the microbial taxa, such as Syntrophobacterales, Thermoleophilia, Geobacter, Spirochaeta, Gaiella, and Defluviicoccus. DOM composition was also associated with the relative abundances of the microbial metabolic pathways, such as anaerobic carbon fixation, glycolysis, lignolysis, fermentation, and methanogenesis.

Conclusions
Our study demonstrates the continental-scale distribution of DOM is significantly correlated with the taxonomic profile and metabolic potential of the rice paddy microbiome. Abiotic factors that have a distinct effect on community structure can also influence the chemodiversity of DOM and vice versa. Deciphering these associations and the underlying mechanisms can precipitate understanding of the complex ecology of paddy soils, as well as help assess the effects of human activities on biogeochemistry and greenhouse gas emissions in paddy soils.
Ancient speciation of the papilionoid legume Luetzelburgia jacana, a newly discovered species in an inter‐Andean seasonally dry valley of Colombia
Authors: da Cruz Daiane Trabuco , Idárraga Álvaro , Banda Karina , Cogollo Álvaro , van den Berg Cássio , de Queiroz Luciano Paganucci , Pennington R. Toby , Lavin Matt , Cardoso Domingos Benício Oliveira Silva 
Published: October 2018

AbstractEcology, geography, morphology, and a combined phylogenetic analysis of DNA sequence variation support the recognition of the new species Luetzelburgia jacana (Leguminosae, Papilionoideae, vataireoid clade). This species is found in the inter‐Andean Rio Cauca Valley in Colombia. Phylogenetic analyses of nine plastid and nuclear DNA sequences from 44 accessions representing all known Luetzelburgia species show that L. jacana is sister to the rest of the genus and has a mean estimated stem age of ca. 4 Ma, much older than other Luetzelburgia species. Luetzelburgia jacana is distinguished by a combination of mostly 7–9‐foliolate, glabrous leaves with leaflets obtuse to shortly acute at the apex, flowers up to 9.6 mm long, and samaras bearing two small lateral wings on the seed chamber. Luetzelburgia jacana, along with two other earliest‐branching species in the genus, L. guaissara and L. trialata, are geographical outliers in the genus, with L. jacana having the northernmost distribution and L. guaissara and L. trialata having the southernmost distributions. These three earliest‐branching species are also ecological outliers within Luetzelburgia by occurring in wetter and less seasonal settings than other species. The discovery of L. jacana resolves these three earliest‐branching species in Luetzelburgia as ecologically transitional between most species of the vataireoid clade that inhabit wet forests and most species of Luetzelburgia that inhabit highly seasonal dry forests and woodlands.
Animal assisted interventions in social work practices <p>Sosyal çalışma uygulamalarında hayvan destekli müdahaleler
Authors: Yeşilkayalı Emel , Ofluoğlu Aslı 
Published: October 2018

Animal-assisted intervention is an intervention method that is shaped on the basis of human-animal relationships and is defined as the use of animals to solve people's problems. The use of animal support, especially in integrated interventions, is becoming increasingly widespread throughout the world, with the effect of scientific evidence. This method can also be used as a social work intervention in disadvantaged groups such as victims of violence, children at risk, victims of trauma, prisoners, elderly people, and people with disabilities. However, there is no study on the use of this intervention in the field of social work in our country. Therefore, the aim of this study is to present a review of the use of animal-based interventions in social work practice, which has been proven in various studies to have positive effects in improving, developing and maintaining physical, psychological and social well-being. In order to reach this aim, the historical process, definition and benefits of animal-assisted therapy and animal-assisted intervention are emphasized. Later, the theoretical foundations of the animal-assisted interventions, their use in social work interventions and the role of social workers in these team work required interventions are revealed. ÖzetHayvan destekli müdahale insan-hayvan ilişkisi temelinde şekillenen, insanların problemlerini çözme amacıyla hayvanların kullanımı olarak tanımlanan bir müdahale yöntemidir. Bilimsel kanıtların da etkisi ile özellikle bütüncül müdahalelerde hayvan desteğinden yararlanma, tüm dünyada giderek yaygınlaşmaktadır. Bu yöntem, şiddet mağdurları, risk altındaki çocuklar, travma mağdurları, mahkumlar, yaşlılar, engelliler gibi dezavantajlı gruplarda sosyal çalışma müdahalesi olarak da kullanılmaktadır. Bununla birlikte ülkemizde sosyal çalışma alanında bu müdahale hakkında herhangi bir çalışma bulunmamaktadır. Bu nedenle bu çalışmanın amacı, fiziksel, psikolojik ve sosyal sağlığın iyileştirilmesi, geliştirilmesi ve korunmasında olumlu etkileri çeşitli araştırmalarla kanıtlanmış olan hayvan destekli müdahalenin sosyal çalışma uygulamalarında kullanımına ilişkin bir derleme sunmaktır. Bu amaca ulaşabilmek için, önce hayvan destekli tedavi ve hayvan destekli müdahalenin tarihsel süreci, tanımı ve yararları üzerinde durulmuştur. Daha sonra hayvan destekli müdahalelerin teorik çerçevesi, sosyal çalışma müdahalelerinde kullanımı ve ekip çalışması gerektiren bu müdahalelerde sosyal çalışmacıların rollerinin ne olduğu ortaya konmuştur.
Comparing the Effects of Listening Input and Reading Input on EFL Learners’ Incidental Vocabulary Acquisition
Authors: Chang Le , Ma Juncai 
Published: October 2018

AbstractThis study examined the effects of either listening or reading input on 88 first-year non-English-major Chinese university EFL students’ incidental acquisition in vocabulary form, meaning and production. The students were put into a Listening Group (n = 47) and a Reading Group (n = 41), each of which finished either two listening activities (each consisting of a dialogic text and an information transfer task) or two reading activities (each consisting of a reading text and five multiple-choice questions). The four texts all contained five low-frequency target words which a revised Vocabulary Knowledge Test had shown to be only slightly known by the participants before the activities. The results of the post-tests showed that the Reading Group had general acquisition advantage over the Listening Group in terms of all the three vocabulary aspects, and due to the fact of rich target word contexts and repeated access to the texts, the Listening Group manifested vocabulary meaning acquisition nearly equal to the Reading Group. Overall, the study shows the notably advantageous effects of reading input on incidental vocabulary acquisition, and concerning facilitating vocabulary acquisition through listening, it points out the importance of increasing opportunities for learners to process listening input with rich contextual clues through task repetition.
An ERP Study on the Processing of Chinese Applied-Object Structures
Authors: Zhou Changyin , Zhang Yuhuan 
Published: October 2018

AbstractVerb-argument relation is a very important aspect of syntax-semantics interaction in sentence processing. Previous ERP (event related potentials) studies in this field concentrated on the relation between the verb and its core arguments. The present study aims to reveal the ERP pattern of Chinese applied object structures (AOSs), in which a peripheral argument is promoted to occupy the position of the patient object, as compared with the patient object structures (POSs). The ERP data were collected when participants were asked to perform acceptability judgments about Chinese phrases. The result shows that, similar to the previous studies of number-of-argument violations, Chinese AOSs show a bilaterally distributed N400 effect. But different from all the previous studies of verb-argument relations, Chinese AOSs demonstrate a sustained anterior positivity (SAP). This SAP, which is very rare in the studies related to complexity of argument structure operation, reflects the integration difficulty of the newly promoted arguments and the progressive nature of well-formedness checking in the processing of Chinese AOSs which is in accordance with the metonymic mechanism of non-patient objects in the relevant cognitive study. It shows that, in Chinese, which is a paratactic language, semantics (thematic roles) plays a more important role in the syntax-semantics interface than that in hypotactic languages.
Epidemiological study of carbapenem-resistant Klebsiella pneumoniae
Authors: Lin Di , Chen Jian , Yang Yan , Cheng Jun , Sun Changgui 
Published: October 2018

Abstract

Background
This research is aimed to study the resistance and molecular epidemiological characteristics of carbapenem-resistant Klebsiella pneumoniae (CRKP).

Methodology
38 isolated CRKP strains were collected from clinical specimens.

Results
The resistance rates were more than 70.0%. Ampicillin had the highest rates among them (100.0%). 34 strains (89.5%) among the 38 CRKP strains carried bla
KPC-2 gene, and 3 strains (7.9%) carried bla
IMP-4 gene. 36 strains (94.7%) among the 38 CRKP strains carried bla
SHV gene, 29 strains (76.3%) carried bla
TEM gene, and 26 strains (68.4%) carried bla
CT-M gene. 7 strains (18.4%) among the 38 CRKP strains carried bla
DHA-1 gene. 15 strains (39.5%) in 38 CRKP strains lost two fenestra proteins, ompK35 and ompK36, and the rest 23 strains carried ompK36 genes. 38 CRKP strains were divided into five kinds of ST types, with ST11 type as the most (86.8%, 33/38). The rest of the ST types included 2 strains of ST23 (5.3%, 2/38), one strain of ST15, ST1373 and ST1415 (2.6%, 1/38).

Conclusions
CRKP resistance is severe, and the mechanism of drug resistance has become increasingly complex. Various ST types and resistance genes are related to CRKP. The clinical prevention and control work is imminent.
Cruel but not Unusual
Authors: Polizzi David , Arrigo Bruce 
Published: October 2018

The practice of solitary confinement has been utilized by the American penitentiary system since its inception. The deleterious health and mental health consequences stemming from this type of correctional practice have led several clinical researchers and legal advocates to call for solitary confinement’s abolition based on constitutional prohibitions against cruel and unusual punishment. However, the U.S. Supreme Court has not found that the conditions of isolative confinement establish a legal threshold sufficient to legitimate such a ban. In fact, Justice A. Scalia famously argued that although it may be true that solitary confinement is cruel, it is certainly not unusual and is therefore not prohibited by the Constitution. This judicial attitude coincides with the more general proclivity of the Court, which has articulated a position against becoming overly involved in the administration of American penitentiaries. If it is true that the Constitution does not stop at the jail house door, then how do we make sense of the U.S. Supreme Court’s position on solitary confinement?
In this article, we explain how solitary confinement reflects the blurring of the legal and the political (a state of exception), and we describe how the Court’s cruel-but-not-unusual justification sustains what Agamben has called a zone of indifference. As we demonstrate, the legal arguments offered by the Court simply reflect the institutionalization of this process. This process reveals the narrative construction of captivity’s laws at the level of U.S. Supreme Court decision making. These laws endorse the ideology of rationalized retribution.
Ainda (e sempre) Saussure: história, memória e discurso em três versões de um mesmo texto
Authors: Scherer Amanda Eloina , Costa Maria Iraci Sousa 
Published: October 2018

No presente artigo, desenvolveremos uma reflexão acerca do contexto de produção de três versões do Curso de Linguística Geral (CLG), a saber, a versão publicada na Argentina e aquelas publicadas no Brasil e em Portugal. Nosso objetivo é compreender como o CLG é recebido/lido em cada momento histórico fora do contexto francês. Selecionamo-las não só pela relação singular com a língua, mas porque elas são propostas em conjunturas em que o CLG é recebido/lido de forma diferente. Além disso, nas referidas publicações, consideraremos também uma passagem que é bastante controversa, mesmo na edição francesa, aquela que trata do exemplo dado para ilustrar o princípio do arbitrário do signo. Ao comparar essa passagem nas diferentes situações, queremos entender como se inscreve o gesto de interpretação do sujeito que se responsabilizou pela versão da obra em cada um dos países em questão.