bluuebunny/crossref_metadata_2025_split huggingface dataset:
Proteomic technologies in the development of new vaccines based on serotype-non-specific protein antigens of Streptococcus pneumoniae
Authors: Tyuri Yu A , Zaripova A Z , Isaeva G Sh , Mustafin I G , Bayazitova L T 
Published: August 2019

The review presents a modern strategy to improve the means of vaccine prevention of streptococcal infections aimed at finding and developing new vaccines for immunization of people belonging to risk groups. It should be noted that pneumococci (S. pneumoniae) are members of gram-positive bacteria (diplococci) and become the main cause of various nosological forms of human infectious diseases (such as pneumonia, otitis media, sinusitis, bacteremia and meningitis). Existing pneumococcal vaccines (conjugate and polysaccharide) have some important limitations, for example, serotype dependence, loss of effectiveness due to a change in the serotype landscape, insufficient protective effect from non-invasive forms of pneumococcal infections and high production costs associated with the development of these products. The main part of the review presents the most important research papers that used modern proteomic technologies in the study of the S. pneumoniae proteomic profile. These works allow us to evaluate at the molecular level the importance of bacterial proteins as candidates for creating new combination vaccines that can effectively protect against the full range of pneumococcal serotypes circulating in the human population. So, in particular, the data are provided on the new methodology for the analysis of the proteome of extracellular S. pneumoniae bacterial microvesicles to identify immunoreactive protein antigens, potential candidates for inclusion into vaccines. As a result of these studies, 15 immunoreactive proteins were discovered, 7 of which are cytosolic and 8 proteins are bound to the cell surface (MalX, ABC transporter or substrate binding transport protein, AmiA, AliA, LytC, IgA1 protease, PspA and the putative precursor of β-galactosidase). These are possible candidates for developing combination vaccines. Additionally, the review presents data on the role of significant virulence factors of the protein nature of S. pneumoniae strains in nasopharyngeal colonization, increased infectivity, as well as on overcoming reactions of the host's immune response.
Analysis of pathologies among workers of a large enterprise of housing and communal services based on the results of periodic medical examinations
Authors: Bendyuk G Ya , Dokhov M A , Sidorov A A 
Published: August 2019

Aim. The determination of age-specific coefficients of pathologies in the team of SUE “Vodokanal of St. Petersburg” for 2015–2017.
Methods. The study was conducted in the Medical unit of SUE “Vodokanal of St. Petersburg” in 2015–2017. 8600 people were followed up for 3 years. During the study, extensive indicators of the structure of the pathological process and intensive indicators characterizing its prevalence were calculated.
Results. As a result of the study, it was found that the first place (27.1%) in the structure of pathologies both in men and women is occupied by diseases of the eye and its adnexa. At the second ranked place (25.7%) there were diseases of the circulatory system. As a result of the study, age groups with a high rate of increase in morbidity were identified. Thus, the rate of increase in the detection of pathology of the circulatory system at the transition from the age group below 25 years to the age group 25–29 years was 73.7% among men and 80.4% among women. It was found that diseases of the ear and mastoid process were more common among men, and the greatest increase in the incidence was recorded in the age group 25–29 years. At the same time, diseases of the genitourinary system were more common in women, and the highest incidence rate was revealed in the age group 40–44 years.
Conclusion. Тhe results indicate the need for a differentiated approach to planning the volume of preventive work in different age groups of employees of the housing and communal services enterprise.
A Culture of Conflict: An Examination of Thought Processes and Subsequent Behaviors of Citizens in Post-War Belfast
Authors: Smith Nicole Finnell 
Published: August 2019

This article is an exploration into the thoughts and behaviors of the citizens of Post-War Belfast. More than twenty years have passed since the declared end of the Troubles, a three decade-long civil war taking place in Northern Ireland. While many places in Northern Ireland felt the blows of this war, it seems that none felt them quite as badly as Belfast. In this article, I examine the behaviors and actions via the thoughts and perspectives of citizens of Belfast, a city which is still torn in half, divided by forces such as religion, politics, and law among others. These forces are intimately entangled with one another, so much so that the root of the conflict proves difficult to find. After examining the history of Belfast and its peoples, I create two provisional categories, “those too close to the conflict” and “those too far removed from the conflict.” By doing so I am able to explore what is deemed the normative thought processes of varying people groups, which helps outsiders to glean some understanding of their behavior. In the end, my goal is to give voice to varying sides of the conflict, and while not giving any solution to the conflict, I aim to offer some knowledge and insight as to why it is taking place.
Culture Repackaged: An Ethnography of the Globalized Sub-Culture of Tabletop Wargamers
Authors: Lee Rainier 
Published: August 2019

The purpose of this research is to show the changing face of cultural participation in hidden sub-cultures of the West. Through repackaging social partnership to adapt to post-modern realities, Middle-Earth Strategy Battle Gamers establish community, identity, and social mobilization through tabletop wargaming. This research is a call for anthropologists to expand their presence on social media as a means of understanding shifting images of culture. It is also a call for Christian participation in all segments of society.
Glosa do wyroku Europejskiego Trybunału Praw Człowieka z dnia 30 stycznia 2018 roku w sprawie Sekmadienis Ltd. przeciwko Litwie (skarga nr 69317/14)
Authors: Dziwisz Stanisław 
Published: August 2019

Przedmiotem glosy jest wyrok Europejskiego Trybunału Praw Człowieka wydany 30 stycznia 2018 r. w sprawie Sekmadienis Ltd. przeciwko Litwie. Trybunał uznał, że skazanie Spółki na grzywnę w związku z prowadzoną kampanią reklamową wykorzystującą do celów komercyjnych przedmiot czci religijnej stanowiło naruszenie art. 10 Konwencji o Ochronie Praw Człowieka i Podstawowych Wolności. Nałożona kara, w ocenie Trybunału, stanowiła ingerencję w jej wolność wyrażania opinii, która choć była przewidziana w prawie krajowym i realizowała uprawniony cel w postaci ochrony moralności publicznej, to jednak narusza równowagę pomiędzy ochroną moralności i praw osób wierzących, a wolnością słowa.
The Number and Potency of Endothelial Progenitor Cells in Type 2 Diabetes Mellitus Patients
Authors: Darmayanti Siska , Hendriani Rini , Sartika Cynthia Retna 
Published: August 2019

BACKGROUND: Type 2 Diabetes Mellitus (T2DM) is a metabolic disease, due to the disorder of insulin function, insulin secretion, or both. Long-term hyperglycemia conditions promote endothelial dysfunction precedes to the development of multiple organ dysfunctions. Endothelial progenitor cells (EPCs) and hematopoietic stem cell (HSCs) are the key cellular effectors of postnatal neovascularization and play central role in endothelial dysfunction. However, in T2DM condition, the number of apoptotic HSCs increase, it may cause the reduction in potency and number of EPCs. In diabetes, the circulating EPCs number decrease and their functionality is impaired, but mechanism underlie of this impairement is unknown. The purpose of this study was to examine the relationship duration diabetes with the number and potency of EPC cells in T2DM patients controlled and poorly controlled.METHODS: Thirty-eight T2DM male patients were classified into two group based on Indonesian Society of Endocrinology/Perkumpulan Endokrinologi Indonesia (PERKENI) criteria on T2DM. The first group was a controlled glycemic condition group (hemoglobin A1c (HbA1C) <7.0%) and the second group was a poorly controlled glycemic condition group (HbA1C >7.0%). Cluster of differentiation (CD)34+ and CD133+ expressions were used as specific marker for EPC, while quantified bright aldehyde dehydrogenase (ALDHbr) assay was used to represented the potency of EPCs.RESULTS: This study showed that in poorly controlled T2DM group the number of EPCs was lower by 24.80% (p<0.05) compared to the T2DM controlled group. Similarly, the expression of ALDHbr was lower by 43.07% (p<0.05) in poorly controlled group.CONCLUSION: There was a decrease in the number and potency of EPCs in poorly controlled T2DM patients compared to the controlled T2DM patients. There was also a strong negative correlation between the duration of diabetes and number of EPCs.KEYWORDS: ALDHbr, endothelial progenitor cells, type 2 diabetes mellitus
Stratifikasi Sosial Ondhâg Bâsa Bahasa Madura
Authors: Mulyadi Mulyadi , Bukhory Umar 
Published: August 2019

Bahasa Madura, sebagai bahasa, mengalami kepadatan linguistik dan non-linguistik. Namun harus bersaing dengan bahasa nasional dan internasional untuk bertahan hidup sebagai lingua franca. Secara bertahap ditinggalkan oleh penuturnya karena kompleksitas morfologis, prestise, dan praktik komunikasi. Fenomena ini menginspirasi penulis untuk melakukan studi bagaimana penutur Madura menerima bahasa mereka sendiri dan harus menyelidiki karakteristik sosial penutur. Kelas menengah adalah salah satu stratifikasi sosial yang cenderung lebih fleksibel dalam menolak dan mengambil budaya baru dan bahasa adalah bagian dari budaya. Penulis memfokuskan penelitian tentang bagaimana kelas menengah Pamekasan melakukan Madura Ondhâg Bâsa dan bagaimana kelas menengah Pamekasan menerima Ondhâg Bâsa. Penelitian ini menggunakan desain kualitatif dan fenomenologi dalam pendekatan. Hasil penelitian: pertama, kelas menengah Pamekasan sebagian besar menggunakan stratifikasi Madura tingkat rendah, bâsa mabâ, dipertukarkan dengan bahasa Indonesia dalam percakapan sehari-hari alih-alih mempraktikkan stratifikasi tingkat Madura yang lebih tinggi menengah (bása alos) dan tingkat tinggi (bâsa tèngghi). Situasi bahasa ini mudah ditemukan pada percakapan antara pasangan suami-istri, anak-anak dan orang tua, saudara kandung, lingkungan baik dalam situasi formal dan non-formal. Kedua, dari temuan ini dapat secara interpretatif dijelaskan bahwa Ondhâg Bâsa Madura diterima dengan cara-cara berikut: sebagai ungkapan keadilan, strategi kesopanan, strategi ice breaking, pernyataan posisi, percepatan prestise, dan strategi ekonomi. (Madurese, as language, experience linguistic and non-linguistic densities. It must compete to national and international languages to survive as lingua franca; it is gradually left by its speakers due to its morphological complexity, prestige, and communication practice. This inspires to conduct a study how the Madurese speaker accept their own language and must also investigate the social characteristics of the speakers. Middle class is one of the social stratifications that tend to be more flexible in rejecting and taking new culture and language is part of culture. The writer focuses the research on how middle class of Pamekasan perform Madurese Ondhâg Bâsa and how middle class of Pamekasan accept Ondhâg Bâsa. Qualitative design and phenomenology in approach of this research. The result: firstly, the middle class of Pamekasan mostly use the low level of Madurese stratification, bâsa mabâ, interchangeably with Indonesian in daily conversation instead of practice the higher level of Madurese stratification middle (bâsa alos) and high level (bâsa tèngghi). Secondly, from this finding it could be interpretatively described that Madurese Ondhâg Bâsaare accepted in the following ways: as the expression of equity, strategy of politeness, strategy of ice breaking, statement of position, prestige acceleration, and economic strategy.)
Improving Students and Community Participation in Preserving Mangrove Forest Bangkala Jeneponto South Sulawesi with a Constructivism based Booklet
Authors: Amin Astuti Muh. 
Published: August 2019

Knowledge dominantly affects community attitudes and participation in mangrove forest conservation. One of the effective ways to solve issues related to preserving mangrove forest in Jeneponto regency is to distribute a constructivism based booklet which introduces the functions, impacts, and management of the forest. This study was conducted in Bangkala District, Jeneponto regency, South Sulawesi from 11 August 2016 to 25 December 2016. Purposive sampling was employed to determine the research sample based on certain consideration. Data was collected using: (1) a questionnaire to elicit responses from some students and community members in Bangkala Jeneponto South Sulawesi towards a booklet developed on the constructivist theory; (2) another questionnaire and interview schedule to obtain community perception on the forest conservation activities; (3) socialization activities at schools and community centers related to the importance of sustainable mangrove forest development. Research findings indicate that: (1) the students and the community members of Bangkala, Jeneponto, South Sulawesi have provided positive and supportive responses towards the development of the constructivism booklet; (2) the society members have realized the significance of mangrove forest development; (3) overall, the students and the community members in Bangkala, Jeneponto, South Sulawesi have been highly involved in preserving the mangrove forest. Assistance to sustain this participation; however, is still necessary.
Keywords: Booklet, Mangrove Conservation, Students, Participation, Community.
Development of Biology Interactive Digital Flipbook on the Subject of Animal Growth and Development
Authors: Abadiyah Rifda , Prihatin Jekti , Murdiyah Siti 
Published: August 2019

Flipbook is organization of learning materials containing text, sound, animation, and video. This research aimed to produce a learning materials in the form of flipbook, especially on subject of animal’s growth and development for science class grade XII. The flipbook produced should be valid, effective and practical for use in learning process. Flipbook is a 2 dimensional application that is reliable and lightweight. This study used 3 stages from 4 dimensional model which are define, design and develop. The implementation of the developed product was planned by 2 different tests, the first was limited testing and second was field trial. All tests implemented in 44 students of 12 IPA SMA Budi Utomo Sidoarjo. The results showed that 1) an average score of 81.43 gained from 3 different experts which falls into a very valid category, 2) field trial got an average score of 88.46 also falls into very valid category, 3) pre-test, post-test 1 and post-test 2 got normalized gain score at 0.78 which meant that the improvement of learning outcomes after using Flipbook was very high, 4) the effeciency based on the students' response was 97.72% which was interpreted in very good category. It can be concluded that the developed Flipbook was easy and feasible to use in learning.
Keywords: Flipbook, validity, effectiveness, practicality result, research and development
Studi Pendahuluan: Pembelajaran Berbasis Local Wisdom disertai Strategi Integrated Science untuk Melatihkan Keterampilan Berpikir Kritis IPA Siswa SMP
Authors: Lestari Wahyuning Putri 
Published: August 2019

Education is a process to provide opportunities for students to be able to improve, increase knowledge, skills, attitudes and behavior that are primarily related to critical thinking skills. The success of education can be influenced by several learning factors so that in choosing methods, approaches, models, and strategies, it has an impact on determining the success and failure of a learning. The solution related to the explanation is by using local wisdom-based learning accompanied by an integrated science strategy. This learning emphasizes local wisdom based on learning activities through integrated science strategies. The purpose of this study is to provide alternative solutions related to the learning process to train critical thinking skills of junior high school students. The method used in this study is the study literature on the sharing of related sources. Based on the results of this study is expected to provide a solution to train critical thinking skills of junior high school students.

Kata Kunci: local wisdom based learning; integrated science strategies; and students' critical thinking skills
UJI METODE CERAMAH DAN TEORI BELAJAR KONTRUKTIVISME UNTUK CARA BELAJAR SISWA MENENGAH PERTAMA NEGERI 2 ARJASA
Authors: Hafizh Dary Farhan 
Published: August 2019

Abstract
This study descriptively aims to determine the tendency of learning achievement, using constructivism learning models compared to lecture learning models. Data retrieval is done by observing, giving questionnaires and interviews with the subjects of students from schools of junior high school 2 Arjasa. Descriptive research results show that learning using the lecture learning method provides more understanding to students when compared to the constructivism learning model.

Keyword: study; Observation; learning
PENINGKATAN KEAKTIFAN SISWA DAN HASIL BELAJAR DENGAN MENGGUNAKAN METODE PEMBELAJARAN PROBLEM BASED LEARNING PADA SISWA SMPN 1 MAYANG KELAS IX
Authors: Sari Rohmah Juwita , Utomo Anjar Putro 
Published: August 2019

Abstrak: motivasi siswa untuk cenderung aktif dalam belajar keaktifan di pengaruhi oleh proses belajar mengajar guru. Proses pembelajaran sangat memerlukan keaktifan siswa, tanpa adanya keaktifan siswa maka pembelajaran terkesan membosankan. Keaktifan siswa sebagai unsur terpenting dalam pembelajaran, karena keaktifan akan berpengaruh besar pada keberhasilan proses pembelajaran Proses pembelajaran yang baik akan selalu melibatkan siswa secara aktif dalam setiap kegiatan pembelajaran sehingga dapat membangkitkan motivasi siswa, yang pada akhirnya siswa akan memperoleh prestasi belajar yang optimal. Guru sebagai pembimbing pada dasarnya merupakan upaya membantu siswa yang mengalami masalah belajar agar dapat mengembangkan segenap potensi yang dimilikinya melalui hubungan interpersonal yang akrab dan saling percaya. Guru berusaha membimbing siswa agar dapat menemukan berbagai potensi yang dimilikinya, membimbing siswa agar dapat mencapai dan melaksanakan tugas-tugas perkembangan mereka, sehingga dengan ketercapaian itu mereka dapat tumbuh dan berkembang sebagai individu yang mandiri dan produktif.

Kata Kunci: Keaktifan, problem based learning,
Hematemesis on Hepatic Cirrhosis Patients in Area with Limited Facilities
Authors: Klahan Yudha , Alkaff Firas Farisi 
Published: August 2019

Esophageal variceal haemorrhage is one of the more dangerous complications of hepatic cirrhosis. Initial treatment can determine patient mortality and morbidity. But not all hospitals have adequate facilities and medicines to handle it. The 53-year-old woman came with a diagnosis of ascites and hematemesis. At the initial examination found hypotension. Laboratory results show anemia, thrombocytopenia, and leukocytosis. The next morning the patient's condition worsened and was transferred to ICU. During the ICU patients receive 10 lpm oxygen support, cefobactam, pantoprazole, PRC transfusion, and dopamine. Patients begin conscious on the 5th day of treatment. Then the patient started getting diuretics on day 6 and propranolol on day 9. On day 13 the patient's condition improved and the patient was discharged for outpatient treatment. Limitations of the endoscopic tool cause not every hospital in Indonesia can perform emergency endoscopy for therapy. However, with rapid and appropriate pharmacological therapy, patients can be helped not to fall into mortality and prevent recurrent bleeding.
FAKTOR-FAKTOR PEMILIHAN LOKASI SHOPPING MALL DI KOTA SURAKARTA
Authors: Hall Darryl , Astuti Winny , Rini Erma Fitria 
Published: August 2019

Lokasi merupakan penentu daya tarik suatu pasar modern. Menurut (Berman &amp; Evan, 2001), faktor yang menentukan lokasi optimum suatu retail/perdagangan yaitu aksesibilitas, specific site, kebijakan zonasi dan secara lebih detail (Marlina, 2008) dan (Kwak &amp; dkk, 2013), menjelaskan bahwa faktor pemilihan lokasi yang mempengaruhi investor dalam menentukan lokasi Shopping Mall adalah Kesesuaian Aturan Zonasi, Aksesibilitas, Harga Tanah, Ketersediaan Jaringan Prasarana, Kesesuaian kondisi geologi dan hidrologi, Jarak jangkauan customer, dan Tenant Mix. Shopping Mall umumnya merupakan bangunan besar, tertutup lantai lebih dari satu dengan luas minimal 9200 m2. Karakteristik utama Shopping Mall adalah merupakan pusat perbelanjaan dalam satu atap atau one stop (Levy &amp; Weitz, 2009). Perkembangan penanaman modal di Surakarta sebagai Trade Centre membuat banyak investor yang menanamkan modalnya dibidang perdagangan. Salah satu jenis perdagangan yang sedang berkembang di Kota Surakarta adalah Shopping Mall. Perkembangan Shopping Mall diawali pada tahun 2004 ketika Solo Grand Mall berdiri, selanjutnya Solo Square pada tahun 2006 dan Solo Paragon pada tahun 2010. Ketiga Shopping Mall ini memiliki faktor pemilihan lokasi yang sama yaitu memilih lokasi di bagian selatan Kota Surakarta. Sehingga penelitian ini dilakukan untuk mengetahui Faktor Prioritas yang mempengaruhi pemilihan lokasi Shopping Mall di Kota Surakarta dengan menggunakan analisis prioritas dalam Analytic Hierarchi Process. Berdasarkan hasil analisis AHP, faktor yang menjadi prioritas bagi Shopping Mall di Kota Surakarta secara berurutan yaitu Peraturan Zonasi Daerah Setempat, Konsumen dan Ketersediaan Moda Transportasi, Tingkat Arus Lalu Lintas, Kemudahan Dicapai dari Fasilitas Umum, Ketersediaan Jaringan Listrik, Biaya (Harga Lahan), Ketersediaan Jaringan Drainase, Kesesuaian Kondisi Geologi dan Hidrologi, Suspicient, Generative, dan yang terakhir adalah Lokasi dan Jarak dengan Pesaing