bluuebunny/crossref_metadata_2025_split huggingface dataset:
Anti-angiogenic Treatment in Metastatic Colorectal Cancer: Current Issues and Future Aims
Authors: Giulia Martini , Teresa Troiani , Claudia Cardone , Paolo Vitiello Pietro , Davide Ciardiello , Floriana Morgillo , Fortunato Ciardiello , Erika Martinelli 
Published: November 2018

:
Blocking angiogenesis represents a fundamental process in Colorectal Cancer (CRC)
treatment. VEGF (vascular endothelial growth factor) pathway is implicated in various processes
that regulate tumor vascularization and proliferation. In the last years, great efforts have been
made thanks to the discovery of targeted drugs that block VEGF and its receptors conferring a
benefit in a variety of tumors, including CRC. To date, four drugs have been approved for the
treatment of metastatic CRC (mCRC): bevacizumab, aflibercept, ramucirumab and regorafenib.
Unfortunately, patients relapse due to the appearance of resistance. The VEGF family, its role in
the angiogenesis and complex heterogeneity of mechanisms that escape tumor blockade are not
completely understood and there is a lack of biomarkers of response to anti-angiogenic drugs. We
describe the principal mechanisms of resistance to anti-VEGF therapy and discuss potential biomarkers
to be investigated in the near future.
Electrospun Polymer Nanofiber from Moringa Oleifera Kernel Oil with Coaxial Electrospinning Method
Authors: Afolabi-owolabi Oluwafunke T. , Abidin Syahariza Z. , Ariffin Fazila 
Published: November 2018

Background:
Moringa oleifera kernel oil consist of monounsaturated fatty acid with high
percentage of oleic acid. The oil consist of phytochemicals, bioactive compounds and nutrients that
have several application in health industries. However, the oil degrades on exposure to light, heat and
oxygen overtime. In addition, rancidity cause the oil quality to defect and reduce the shelf-life.
Therefore, microencapsulation techniques are uniquely applied to oil to preserve their native quality
and prolong their shelf life.

Objective:
This study examines different polymer concentrations and injection flowrates of zein nanofiber
from Moringa oleifera kernel oil using coaxial electrospinning method.

Methods:
A 40% w/v zein polymer was the optimal loading concentration and 0.7 mL/hour of zein
polymer with 0.1 mL/hour of Moringa oleifera kernel oil was the optimal injection flowrates for
electrospun nanofiber. Analysis of the Moringa oleifera kernel oil and polymer sample micromorphology,
were investigated with Field Emission Scanning Electron Microscopy (FESEM) and transmission
electron microscopy (TEM).

Result:
result shows uniformly layered nanofiber. The nanofiber has no beads formation and the fiber
strands are continuous with no entanglement. The polymer encapsulated the oil efficiently. Furthermore,
thermal analysis through Differential Scanning Calorimetry (DSC) showed consistency in
the nanofiber thermal behavior. Thermogravimetric (TGA) analysis revealed the weight loss and
thermal dissociation of the polymer structure. The electrospun nanofiber average diameter was 450 ±
24 nm and exhibited hydrophobicity.

Conclusion:
The co-axial electrospine technique was effective in fabricating electrospune nanofibers.
Bioactive Compounds from the Flower Part of Polygonum maritimum L. Collected from Algerian Coast
Authors: El Haci Imad Abdelhamid , Mazari Wissame , Atik-Bekkara Fawzia , Mouttas-Bendimerad Fatma , Hassani Fayçal 
Published: November 2018

Background:
Polygonum maritimum is one of the spontaneous halophyte plants of the Algerian
coast. Many studies were carried out to evaluate the contents and the quality of phenolic compounds
of this plant around the Mediterranean region. Objective: This paper intends to identify, for the
first time, the phenolic compounds from the flower part of P. maritimum.

Methods:
RP-HPLC-PDA (Reversed Phase-High Performance Liquid Chromatography-Photo Diode
Array) material was used for this purpose. Many standards were used and their retention times were
stored in a local database. Identification was made on the basis of retention times of retained compounds
and those found in the literature, and UV spectra of each peak.

Results:
This study intends to identify five phenolic acids (gallic, ferulic, sinapic, caffeic and syringic
acids), one flavonol (rutin) and one flavanone (naringenin).

Conclusion:
P. maritimum is an important source of natural bioactive compounds that can be exploited
for the benefit of many fields.
Supervised Dimension Reduction by Local Neighborhood Optimization for Image Processing
Authors: Zhao Liyan , Wang Huan , Wang Jing 
Published: November 2018

Background:
Subspace learning-based dimensionality reduction algorithms are important
and have been popularly applied in data mining, pattern recognition and computer vision applications.
They show the successful dimension reduction when data points are evenly distributed in the
high-dimensional space. However, some may distort the local geometric structure of the original dataset
and result in a poor low-dimensional embedding while data samples show an uneven distribution
in the original space.

Methods:
In this paper, we propose a supervised dimension reduction method by local neighborhood
optimization to disposal the uneven distribution of high-dimensional data. It extends the widely used
Locally Linear Embedding (LLE) framework, namely LNOLLE. The method considers the class label
of the data to optimize local neighborhood, which achieves better separability inter-class distance
of the data in the low-dimensional space with the aim to abstain holding together the data samples of
different classes while mapping an uneven distributed data. This effectively preserves the geometric
topological structure of the original data points.

Results:
We use the presented LNOLLE method to the image classification and face recognition,
which achieves a good classification result and higher face recognition accuracy compared with existing
manifold learning methods including popular supervised algorithms. In addition, we consider
the reconstruction of the method to solve noise suppression for seismic image. To the best of our
knowledge, this is the first manifold learning approach to solve high-dimensional nonlinear seismic
data for noise suppression.

Conclusion:
The experimental results on forward model and real seismic data show that LNOLLE
improves signal to noise ratio of seismic image compared with the widely used Singular Value Decomposition
(SVD) filtering method.
The Inventive Activity in Biodiesel Production
Authors: Angulo-Cuentas Gerardo , Cadena-Wilches Luz , Nuñez-Mejia Elvis 
Published: November 2018

Background:
Biodiesel is an energy source considered of great importance in both
production processes and to satisfy domestic needs. However, production and use of this biofuel
have troubles regarding the sustainability and efficiency.

Objective:
Considering the problems in the production of a sustainable and efficient biodiesel carrie,
this study of patents analysis was done having the main objective to identify new technologies related
to biodiesel production and the solution to these problems.

Methodology:
: For the study, a methodology was implemented that allowed the analysis of patents
related to biodiesel production published between 2010 and 2016. The stages of the methodology
include: search in the patent database; analysis of the technological development at the global level,
and identification and description of technological trends.

Results:
The search resulted in 1053 patent’s applications. Among the results, technology indicators
are described such as the life cycle of the technology, leading applicants, industrial impact index,
technological variability, among others.

Conclusion:
The results show information related to technologies that can be useful for biodiesel
industry since technological fields granting solutions to the inconvenient respecting the production
of this biofuel were identified. Technological trends found are focused on extracting useful products
for biodiesel industry through production, genetic mutation, growing and processing of oleaginous
microorganisms.
Deboronation of New Clarithromycin-Benzo[c][1,2]oxaborole Conjugates
Authors: Lapa Gennady B. , Isakova Elena B. , Mirchink Elena B. , Preobrazhenskaya Maria N. 
Published: November 2018

<P>Background: The conjugates of antibiotics are new molecules that might show new antibacterial
spectrum and overcome resistance of insusceptible bacterial strains. Modification of
known antibiotics like Clarithromycin with active fragments is laborious and proven method to
overcome resistance of such strains.

Methods:
The conjugates of Clarithromycin and Benzo[c][1,2]oxaboroles were synthesized using
long linkers to extend antimicrobial spectrum of this antibiotic.

Results and Discussion:
Unexpected intramolecular deboronation of these bioconjugated was
found to occur when the linker contained two or more CH2-groups. Molecular modeling was used
to understand the source of instability and show a possibility of intramolecular complex of carbonyl
group at C-9 in Clarithromycin core and hydroxy-borole moiety. This could facilitate nucleophilic
attack of methanol used in reactions to destroy benzo[c][1,2]oxaboroles fragments and
leave stable hydroxyl-aryl molecules.

Conclusion:
The loss of boron from benzo[c][1,2]oxoborole fragments leads to the significant decrease
of antimicrobial activity of synthesized antibiotics.</P>
Current Research and Patents of Plant Fiber Composites
Authors: Wang Jiankang , Li Zhijian , Lu Hongwei 
Published: November 2018

Background:
With the improvement of environment protection awareness, human beings
have gradually become aware of that the plastic products, waste are harmful to the human living environment.
Therefore, research and application of biodegradable materials that do not rely on petroleum
resources have become hot topics. Researchers have accelerated the development and promotion of
plant fiber because they are good flexibility, relatively rough surface and biodegradable.

Objective:
The development of plant fiber composites is reviewed, including composition ratio, interfacial
modification, processing technology, and the effects of these technologies on the properties of plant
fiber composites.

Methods:
The paper reviews various patents and research developments about plant fiber composite
materials. It also analyzes the advantages and disadvantages of various patents and technologies from
the aspects of biodegradable ability, mechanical properties, dispersing performance, processing properties,
cost, and so on.

Results:
The component proportion, interface modification, and processing technology of plant fiber
composite materials are prospected to improve the quality and application of the plant fiber composite
materials in the future development.

Conclusion:
The considerable attention has been paid on the technology of biodegradable plant fiber
composite. The recent patents and technologies have shown us a wider application in biodegradable
plant fiber composite. The problems how to improve the mechanical properties of plant fibers, the dispersion
properties of plant fibers and resins, and the processing properties of composite materials, will
need more and more methods and equipment to solve or simplify.
MEMAHAMI PARIWISATA MELALUI PENDEKATAN GEOGRAFI MANUSIA
Authors: Hastuti Hastuti 
Published: November 2018

AbstrakIndonesia memiliki keanekaragaman sosial budaya didukung kekayaan sumberdaya alam yang tersebar dari Sabang hingga Merauke maupun dari Miangas hingga Talaut, dapat dijadikan tumpuan pengembangan pariwisata yang diharapkan mampu memberikan kontribusi peningkatan penghidupan masyarakat. Indonesia gencar mempromosikan kekayaan alam, sosial, dan budaya berbagai wilayah sebagai tempat tujuan wisata yang menarik bagi wisatawan domestik dan wisatawan asing. Bali, Yogyakarta, Nusa Tenggara, serta beberapa wilayah di Sumatera dan Sulawesi potensial sebagai destinasi wisata potensial bertumpu pada sosial, budaya, dan alam. Pariwisata menarik perhatian pemerintah melalui paket-paket kebijakan seiring pariwisata juga mulai dikembangkan menjadi kajian keilmuan yang menarik pada berbagai disiplin di perguruan tinggi, tak terkecuali geografi juga mengkaji pariwisata sebagai salah satu sub-disiplin dari geografi manusia. Geografi pariwisata mulai dikenalkan sebagai cabang disiplin geografi manusia (Kitchin dan Tate, 2000). Kajian pariwisata dikembangkan dengan pendekatan geografi manusia. Geografi manusia mengenalkan pendekatan humanistic, pospositivistic, radicalism, dan femisnism untuk mengkaji aspek antroposfer (Johnston dkk, 2000). Kata kunci: Pariwisata, Geografi Manusia
KARAKTERISTIK MATAAIR KAKI LERENG GUNUNG MERAPI DAN PEMANFAATANNYA DI KECAMATAN DUKUN KABUPATEN MAGELANG
Authors: Aurita Ririn Putri , Purwantara Suhadi 
Published: November 2018

AbstrakPenelitian ini dilaksanaan di Kecamatan Dukun Kabupaten Magelang dengan tujuan: (1) Mendekripsikan pola sebaran mataair; (2) Mengetahui potensi, pemanfaatan, dan imbangan antara potensi dan pemanfaatan mataair; (3) Membandingkan kualitas fisik dan kimia mataair pada bentuklahan dataran kaki gunungapi dan dataran fluvial gunungapi berdasarkan persyaratan baku mutu air minum menurut Permenkes RI nomor 492 tahun 2010. Populasi dalam penelitian ini terdiri atas fenomena fisik dan fenomena non fisik. Sampel diambil dengan purposive sampling untuk mataair; area probability sampling untuk kebutuhan air irigasi; dan random sampling untuk rumah tangga pengguna. Data dikumpulkan dengan observasi, wawancara dan dokumentasi. Hasil penelitian: (1) Sebaran mataair berdasarkan “nearest neighbour analysis” berpola mengelompok. (2) Terdapat 33 mataair untuk kebutuhan rumah tangga dan 8 mataair untuk irigasi. Debit terendah 0,16 liter/detik dan tertinggi 16 liter/detik. Rata-rata debit untuk rumah tangga 1,6 liter/detik dan irigasi 13,88 liter/detik. Pemanfaatan mataair untuk kebutuhan rumah tangga tercukupi dan rata-rata imbangan airnya surplus. Pemanfaatan untuk irigasi secara keseluruhan juga tercukupi, namun pada bulan Mei mengalami kekurangan air di Desa Paten. (3) Kualitas fisika dan kimia mataair sesuai dan memenuhi persyaratan kualitas air minum. Kata kunci: Karakteristik Mataair, Kaki Lereng Gunung Merapi, Kecamatan Dukun
ANALISIS RISIKO BENCANA ERUPSI GUNUNG MERAPI DI KECAMATAN DUKUN KABUPATEN MAGELANG
Authors: Ardi Andika Surya , Sumunar Dyah Respati Suryo 
Published: November 2018

AbstrakPenelitian ini bertujuan mengetahui: (1) Tingkat risiko bencana erupsi Gunung Merapi,(2) Sebaran risiko bencana erupsi Gunung Merapi; di Kecamatan Dukun Kabupaten Magelang. Populasi dalam penelitian ini adalah seluruh wilayah Kecamatan Dukun. Sampel diambil menggunakan metode area sampling berdasarkan Peta Kawasan Rawan Bencana (KRB) Gunung Merapi. Pengumpulan data dilakukan dengan wawancara, observasi, dan dokumentasi. Analisis data yang digunakan adalah skoring, overlay, dan penafsiran deskriptif.Hasil penelitian: (1) Tingkat risiko bencana erupsi dapat dibagi menjadi: Sedang, rendah, dan sangat rendah. Semakin tinggi tingkat risiko bencana maka potensi kerugian akibat terjadinya bencana erupsi Gunung Merapi semakin besar. (2) Risiko bencana erupsi terdapat diseluruh wilayah. Sebaran tingkat risiko sedang mendominasi sebagian wilayah Desa Sengi dan Desa Kalibening. Sebaran tingkat rendah mendominasi sebagian besar wilayah Desa Ketunggeng, Desa Banyubiru, Desa Ngadipuro, Desa Wates dan Desa Banyudono. Sebaran tingkat sangat rendah berada di Desa Sewukan, Desa Mangunsoko, Desa Dukun, Desa Kalibening, Desa Sumber, Desa Paten, Desa Krinjing, Desa Sengi dan Desa Ngargomulyo. Kata Kunci: Risiko Bencana, Gunung Merapi, Kecamatan Dukun
IMPLEMENTASI PERATURAN DESA MAJASARI NOMOR 3 TAHUN 2012 TENTANG PERLINDUNGAN TENAGA KERJA INDONESIA (TKI) ASAL DESA MAJASARI
Authors: Guntara Iqbal Bachtiar , Satlita Lena 
Published: November 2018

This research aims to analyze the implementation of policy the protection of indonesian labor Majasari in Majasari village, Indramayu and the policy barriers. This research used descriptive approach with qualitative methods. This technique of data collection is done by way of interview, observation and documentation. An examination of the validity of the data is done by triangulation of sources. The data analysis process includes the collection of data, data presentation, data reduction and withdrawal of the conclusion. The results showed that the implementation of the policy of Indonesian labor protection in the village of Majasari is not yet running to its full potential. Protection undertaken include pre placement, placement, full-time placement and full empowerment and family labor indonesia abandoned integrated. Barriers in the implementation of this policy related to budget that never noted in the budget revenue and expenditure of the village Majasari, a limited number of employees of the village, the absence of mentoring on a full-time business group of Indonesian labor Majasari, low awareness of candidates and after Indonesian labor as well as the implementing party of Labor Placement Private report to the Government of Indonesia village, trouble filling the pregnancy and childbirth on the cow.Keyword: Early Marriage, Population Policy, and Sleman District
Estimación del índice de aborto inducido a través del modelo de Bongaarts. Región Áncash, 2013
Authors: Neciosup Obando Jorge Eduardo , Castro Castillo Eloísa 
Published: November 2018

La presente investigación pretende estimar el índice de aborto inducido en la región Áncash. Para tal efecto se utilizó la base de datos de la Encuesta Nacional ENDES 2013, calculando los diversos indicadores de los componentes del Modelo de los Determinantes Próximos de la Fecundidad propuesto por Jhon Bongaarts, además se ha considerado la medición de la tasa global de fecundidad para la región Áncash, y según el método residual multiplicativo se han obtenido estimaciones como: la tasa de prevalencia de uso de métodos anticonceptivos en 66.5 por cada 100 MEF, de igual modo se estima el índice de abortos en Ca = 0.7734 y la tasa de aborto inducido en la región Áncash que resulta en 110 abortos por cada 1000 nacimientos vivos.
Competencias para la educación superior en el Ecuador del siglo XXI: responsabilidad social y tecnologías
Authors: Pérez Zamora Rita Patricia , Miño Acurio Eugenia Del Carmen , Miño Acurio María Cecilia , Feijoó Vega Wilma Mercedes 
Published: November 2018

El presente artículo aborda la responsabilidad social de las Instituciones de Educación en Ecuador para formar en competencias que inciden en el respeto y reconocimiento de la riqueza en diversidad cultural y de biodiversidad, y por otra parte en competencias digitales para preparar a estudiantes ante la revolución tecnológica a nivel global. El objetivo es aportar a investigadores y docentes del Ecuador un aporte desde la literatura internacional para tener referentes para aplicar en el contexto de su trabajo académico. La investigación es de carácter descriptivo, no experimental fundamentado en revisión de bibliográfica y documentación. Los resultados que se presentan constatan los avances conseguidos en el país desde la constitución de Monte Cristi en materia de atribuir una responsabilidad social a la educación y universalizarla gratuitamente a toda la población al tiempos que disponiendo medidas para impulsar su calidad; de igual modo se señala como debe realizarse un mayor trabajo en proporcionar metodologías para la implementación de las tecnologías y capacitación docente en su uso pedagógico. Se concluye que la situación de la Educación Superior en Ecuador ha conseguido notables avances en la última década, subrayando la importancia de continuar en el fortalecimiento de todo el ciclo educativo para que al llegar a la universidad los estudiantes puedan aprovechar al máximo los recursos a su disposición y contribuir al desarrollo de cada una de las regiones y así al país.
Distribución espacial y evaluación de la contaminación ambiental por mercurio en la región de la Mojana, Colombia
Authors: Marrugo Negrete José , Pinedo-Hernández José , Paternina–Uribe Roberth , Quiroz-Aguas Liliana , Pacheco-Florez Sergio 
Published: November 2018

Objetivo. Se evaluó la distribución de mercurio total (HgT) en sedimentos superficiales, peces, cabello, plantas de arroz y macrofitas, como también el índice de geoacumulación por HgT en sedimentos y el potencial de riesgo por consumo de pescado en diferentes municipios afectados por actividades de minería aurífera que se han desarrollado alrededor en la región de la Mojana, Colombia. Materiales y métodos. La concentración de HgT se determinó mediante descomposición térmica, utilizando un analizador directo de mercurio DMA-80. Resultados. En promedio, las concentraciones de HgT en peces fueron 0.223 ± 0.027 μg/g. Del total de las muestras, 11.6% de peces sobrepasaron el límite permisible establecido por la Organización Mundial de la Salud (0.5 μg/g), siendo 4.2% para especies no carnívoras y 7.4% para especies carnívoras. De las especies ícticas, 76.9% presentan valores de índice de riesgo (HI) superiores a 1. El Índice de Geoacumulación (Igeo) en sedimentos, presenta grado de contaminación de no-contaminado a contaminación moderada para las diferentes estaciones de muestreo. La concentración de HgT en cabello osciló entre 0.17 – 8.8 µg/g. 47% de la población supera el límite permisible establecido como referencia por USEPA: 1 µg g-1. Las concentraciones de HgT en macrofitas (Eichhornia crassipes) y plantas de cultivos de arroz fueron superiores en estaciones de muestreo que reciben corrientes de agua que transportan cargas contaminantes desde áreas de explotación mineras, tendencia similar presentada para sedimentos y peces. Conclusiones. Las actividades mineras han generado un proceso de contaminación gradual por Hg en la cadena alimenticia y actualmente los niveles en peces, arroz y cabello representan una seria preocupación para la salud humana.
Balanced Journalism Amplifies Minority Positions: A Case Study of the Newspaper Coverage of a Fluoridation Plebiscite
Authors: Kiss Simon J. , Rath Karly , Perrella Andrea 
Published: November 2018

Background Public opinion surveys usually report majority support for fluoridation in North America. Yet many local plebiscites produce opposite results. One possible reason is the nature of local media coverage.Analysis This article reports on a content analysis of news coverage and letters to the editor about a fluoridation plebiscite in Waterloo, Ontario. Qualitative research suggested that the groups opposed to fluoridation were more motivated and better organized than those in support. The net effect was news coverage more neutral toward fluoridation than supportive or critical, predominantly framed in terms of risks rather than benefits.Conclusion and implications The findings here emphasize the reactive nature of contemporary journalism. In local fluoridation plebiscites, champions are required to produce news coverage that better conveys the benefits to the public.Contexte Normalement, dans les sondages d’opinion publique en Amérique du Nord, la majorité des répondants appuient la fluorisation. Pourtant, au niveau local, plusieurs référendums obtiennent des résultats contraires. Une raison possible pour ce contraste est la couverture médiatique locale.Analyse Cet article présente une analyse de contenu effectuée sur la couverture médiatique et les tribunes libres concernant un référendum sur la fluorisation tenu à Waterloo (Ontario). Cette recherche qualitative suggère que, dans ce cas, les groupes opposés à la fluorisation étaient plus motivés et mieux organisés que ceux qui appuyaient celle-ci. En conséquence, la couverture de la fluorisation tendait à être neutre plutôt que positive ou négative, avec un accent mis sur les risques plutôt que les bienfaits.Conclusions et implications Les résultats de cette recherche soulignent le caractère réactif du journalisme contemporain. En conséquence, dans les référendums locaux, les partisans de la fluorisation auront intérêt à se mobiliser afin d’encourager des reportages plus axés sur les bienfaits de celle-ci.