bluuebunny/crossref_metadata_2025_split huggingface dataset:
Depression, Socioeconomic Factors, and Ethnicity as Predictors of Cardiorespiratory Fitness Before and After Cardiac Rehabilitation
Authors: Mikkelsen Nicolai , Dall Christian Have , Frederiksen Marianne , Holdgaard Annette , Rasmusen Hanne , Prescott Eva 
Published: November 2018

Purpose:
To determine whether cardiac patients with psychosocial or socioeconomic problems have lower peak oxygen uptake (

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2peak) and whether these factors modify the effect of cardiac rehabilitation (CR).

Methods:
A retrospective cohort study of patients with ischemic heart disease, valvular heart disease, or heart failure referred for CR.

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2peak was assessed by a maximal cardiopulmonary exercise test. Pre-existing depression was defined by use of antidepressants and new-onset depression by a modified Primary Care Evaluation of Mental Disorders (PRIME-MD) questionnaire at CR intake. Socioeconomic status was defined by educational attainment and working status; ethnicity as Western European or non-Western European. Full data from baseline assessment were available on 1217 patients and follow-up on 861 patients.

Results:
Mean ± SD

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2peak before CR was 21.8 ± 6.8 mL/kg/min. After multivariable adjustment, lower

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2peak was associated with lower educational attainment, not working, and non-Western ethnicity but not with depression. Mean improvement of

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2peak following CR was 2.4 ± 4.3 mL/kg/min. After multivariable adjustment educational attainment, employment status and ethnicity were significant predictors of improvement of

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2peak while depression was not.

Conclusion:
Education, attachment to the workforce, and ethnicity were all associated with lower

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2peak before CR, and the disparity was increased following CR. Having pre-existing depression and new-onset depression did not influence

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2peak either before or after CR. These results point to important subgroups in need of specially-tailored rehabilitation programs.
Evaluation of Repurposing Archetypal Preventive Radiological/Nuclear Detectors for the Consequence Management Mission
Authors: Musolino Stephen V. , Buddemeier Brooke , Finfrock Charles , Gomera Jose , Klemic Gladys , Moskowitz Joseph , Roberts Thomas , Schaefer Lance 
Published: November 2018

Abstract
In the first hours or days after an unplanned release of radioactive material to the environment, the radiation detection instruments most widely available to local first responders may be those currently fielded for interdiction missions. This study investigated how such preventative radiological/nuclear detection instruments could perform if repurposed for consequence management missions. A representative sample of three archetypes (body-worn, human-carried, and other/large-detection-volume equipment) encompassed six categories: personal radiation detector, extended-range personal radiation detector, personal emergency radiation detector, radioisotope identification device, human-portable detector/backpack, and vehicle-mounted large-detection-volume detector. Overall 19 models of equipment were included in the study. Laboratory evaluations were designed to assess the capabilities of the instruments in four consequence management missions: exposure rate, integrated exposure, radiation survey, and contamination screening. As applicable, the evaluations included measurement of exposure rate, integrated exposure, overrange response, and angular response. The results were compared to benchmarks from the American National Standards Institute N42.49A. The performance of the instruments for initial screening for contamination was assessed by an automated radioactive source moving past the detectors at various speeds and distances. The results demonstrate that if the equipment is used in accordance with the mission analysis and categories and within the original equipment manufacturer specifications, it is possible to achieve sufficient accuracy to estimate and document doses to responders, plan entries into contaminated areas, detect contamination, and protect the public until such time as outside resources arrive with sufficient numbers of standard health physics instruments and personnel dosimetry to replace the preventative radiological/nuclear detection instruments. This evaluation campaign was conducted to complement the National Council on Radiation Protection and Measurements Report 179, Guidance for Emergency Response Dosimetry.
A Contingency Plan for Catastrophic Loss of Bioassay Services
Authors: Carbaugh E.H. , Antonio C.L. , Lynch T.P. , Nelsen L.A. 
Published: November 2018

Abstract
The catastrophic loss of direct or indirect bioassay services can severely impact a site or facility’s radiation protection program. While highly unlikely, circumstances such as fire, hurricane, other extreme weather conditions, unanticipated events, or contractual business decisions could result in the loss of either the onsite or offsite measurement capabilities for direct or indirect radiobioassay services. The process and elements that need to be addressed in obtaining alternate or replacement bioassay services can be described in relatively simple terms, but can be very complex and time consuming to implement. The contingency plan developed for one large, complex radiobioassay program is a good example for addressing these items.
A Comparison of 2 Online Parent Skills Training Interventions for Early Childhood Brain Injury: Improvements in Internalizing and Executive Function Behaviors
Authors: Aguilar Jessica M. , Cassedy Amy E. , Shultz Emily L. , Kirkwood Michael W. , Stancin Terry , Yeates Keith Owen , Taylor H. Gerry , Wade Shari L. 
Published: November 2018

Objective:
To examine the effectiveness of a web-based parenting intervention (Internet-Based Interacting Together Everyday: Recovery After Childhood TBI [I-InTERACT]) and an abbreviated version (Express) in reducing executive dysfunction and internalizing problems among young children following traumatic brain injury (TBI).

Method:
Parents of 113 children (ages 3-9 years) who had sustained a TBI were randomized to 1 of 3 treatment groups: I-InTERACT, Express, or an Internet Resource Comparison (IRC) group. Parents who participated in either I-InTERACT or Express completed self-guided web sessions and received live coaching of their parenting skills via videoconferencing with a therapist. I-InTERACT included additional psychoeducation, stress management, and family communication skills (eg, marriage, grief, pain, and sleep). Analyses of covariance were utilized to compare the groups on parent-reported executive function behaviors (ie, Behavior Rating Inventory of Executive Function) and internalizing symptoms (ie, Child Behavior Checklist) at baseline and 6 months.

Results:
Parents who participated in Express reported significantly lower levels of executive dysfunction than those in I-InTERACT, β = −0.49; t(2, 73) = −2.47, P = .048, and significantly lower levels of withdrawal than those in the IRC group, β = −0.44; t(2, 74) = −2.22, P = .03. The Express group did not significantly differ from the IRC group on executive function behaviors or the I-InTERACT group on internalizing problems, all P > .05. Children with more problems at baseline, families with lower education levels, and parents with more symptoms of depression benefited most.

Conclusion:
A brief, online parent training intervention may be efficacious in improving executive dysfunction and internalizing problems following early TBI, particularly among children of lower socioeconomic status or with existing behavioral concerns.
A Comparison of Satisfaction With Life and the Glasgow Outcome Scale–Extended After Traumatic Brain Injury: An Analysis of the TRACK-TBI Pilot Study
Authors: Kreitzer Natalie P. , Hart Kimberly , Lindsell Christopher J. , Manley Geoffrey T. , Dikmen Sureyya S. , Ratcliff Jonathan J. , Yue John K. , Adeoye Opeolu M. 
Published: November 2018

Objective:
To evaluate the relationship between satisfaction with life (SWL) and functional outcome after traumatic brain injury (TBI).

Setting and Participants:
The Transforming Research and Clinical Knowledge in Traumatic Brain Injury Pilot study (TRACK-TBI Pilot) enrolled patients at 3 US Level I trauma centers within 24 hours of TBI.

Design:
Patients were grouped by outcome measure concordance (good-recovery/good-satisfaction, impaired-recovery/impaired-satisfaction) and discordance (good-recovery/impaired-satisfaction, impaired-recovery/good-satisfaction). Logistic regression was utilized to determine predictors of discordance.

Main Measures:
Functional outcome: Glasgow Outcome Scale–Extended (GOSE); SWL: Satisfaction with Life Scale (SWLS).

Results:
Of the 586 enrolled subjects, 298 had completed both outcome measures at 6-month follow-up; the correlation between GOSE and SWLS was 0.380. Patients with impaired-recovery (GOSE < 7)/impaired-satisfaction (SWLS < 20) were more likely to have mild TBI (83% vs 62%, P = .012), baseline depression (42% vs 15%, P < .0001), and 6-month depression (59% vs 21%, P < .0001) when compared with patients with impaired-recovery/good-satisfaction. Patients with good-recovery/impaired-satisfaction were more likely to have baseline depression (31% vs 13%, P < .0001) and 6-month depression (33% vs 6%, P < .0001) compared with good-recovery/good-satisfaction.

Conclusion:
Correlation between SWL and functional outcome was not strong, and depression may modulate the association. Future research should account for functional, mental health, and patient-centered outcomes when assessing TBI recovery.
Influence of Treating Ocular Surface Disease on Intraocular Pressure in Glaucoma Patients Intolerant to Their Topical Treatments: A Report of 10 Cases
Authors: Dubrulle Pierre , Labbé Antoine , Brasnu Emmanuelle , Liang Hong , Hamard Pascale , Meziani Lyes , Baudouin Christophe 
Published: November 2018

Purpose:
The purpose of this study was to evaluate the effect of treating ocular surface disease (OSD) in patients with medically uncontrolled primary open-angle glaucoma (POAG) associated with OSD.

Methods:
We compiled a retrospective observational case series of 10 patients with POAG that remained uncontrolled with topical treatments and who were referred for filtering glaucoma surgery. All patients underwent a complete assessment of their glaucoma and ocular surface for both eyes. The main treatments were change of topical antiglaucoma medications to preservative-free equivalents, removal of allergenic treatments or those identified as causing side effects, switch to another therapeutic class with the same efficacy but with a better safety profile and treatment of OSD.

Results:
After a minimum follow-up of 6 months, we observed improved ocular surface in all patients, associated with an intraocular pressure (IOP) decrease or stabilization even if some antiglaucoma medications were removed. The mean IOP significantly decreased from 23.75±9.98 mm Hg to 15.15±4.75 mm Hg (−36.2%; P=0.0001). The mean number of IOP-lowering medications was 3.7±1.06 at presentation and 2.8±0.63 after treatment (P=0.01). The Oxford score also decreased from a mean 1.7±0.67 to 0.4±0.51 (−76.5%; P<0.001). For 2 patients, IOP was not sufficiently reduced after treatment and they finally underwent filtering surgery.

Conclusions:
The prevalence of OSD in POAG patients is very high, particularly in patients with uncontrolled glaucoma with multiple topical medications. Careful management of the ocular surface associated with a reduction of the toxicity of eyedrops may result in improvement of ocular surface health and better IOP control.
Technique and Results of Permanent Medial Tarsorrhaphy for Complex Eyelid Malposition
Authors: Segal Kira L. , Elner Susan G. , Elner Victor M. 
Published: November 2018

Purpose:
To evaluate the results of permanent medial tarsorrhaphy and to describe the surgical technique.

Methods:
Medial tarsorrhaphy was performed on 30 eyelids with symptomatic exposure keratopathy secondary to eyelid malposition. Observational, retrospective review of preoperative and postoperative examination findings was performed.

Results:
Average age of the cohort was 66 years (31–91). Medial tarsorrhaphy was performed to correct eyelid retraction (100%), exposure keratopathy (80%), lagophthalmos (57%), and ectropion (17%) in patients with cranial nerve VII palsy (47%), Graves eye disease (13%), eczema (7%), floppy eyelid syndrome (7%), after Mohs reconstruction (7%), orbital myositis (3%), and neurofibromatosis (3%). Seventy-three percent (73%) of patients had an average of 3 surgeries (N = 22, standard deviation = 1.12, range = 2–7) before undergoing medial tarsorrhaphy. Medial tarsorrhaphy was performed in combination with another procedure in 53% of cases. Palpebral fissure decreased postoperatively an average of 1.1 mm (N = 20; p = 0.005), inferior scleral show decreased 0.72 mm (N = 22; p = 0.03), lagophthalmos decreased 0.4 mm (N = 15; p = 0.27), and superficial punctate keratopathy improved by 61% (N = 27; p = 0.009). Ectropion completely resolved in 4 of 10 patients (40%). Seven patients (23%) required additional surgery following tarsorrhaphy an average of 8 months later (range = 2–16). In 1 patient (3%), a tarsorrhaphy opened prematurely, and 1 patient (3%) requested partial opening of the tarsorrhaphy. Average duration of follow up was 13 months (N = 30, standard deviation = 14.97, range = 0.2–45.7).

Conclusions:
Medial tarsorrhaphy is a safe and effective primary or salvage technique to address complex causes of eyelid retraction, lagophthalmos, ectropion, and exposure keratopathy.
Ropinirole Augmentation for Depression
Authors: Gershon Ari A. , Amiaz Revital , Shem-David Haim , Grunhaus Leon 
Published: November 2018

Abstract

Objective
Evidence both from animal and human studies suggests a role for dopaminergic pathways in the treatment of depression. Ropinirole, a selective agonist of dopamine D2/D3, is in use for the treatment of parkinsonism. Preliminary evidence suggests that such agonists might be useful as antidepressants. We tested whether an add-on ropinirole is an effective in depressed patients.

Methods
We conducted a double-blind, randomized, placebo-controlled trial of add-on ropinirole in depressed patients unresponsive to at least one antidepressant. We recruited 32 unipolar and bipolar patients who remained depressed (modified 21-item Hamilton Depression Rating Scale) despite at least 4 weeks of treatment with an adequate dose of antidepressant medication. Patients received either 2 mg of oral ropinirole or placebo twice daily added on to their current medication and were evaluated weekly for 7 weeks using the Hamilton Depression Rating Scale and Montgomery-Asberg Depression Rating Scale.

Results
No difference in primary or secondary outcome measures was detected between the treatment and control groups.

Discussion
These results differ from previous studies and are unexpected in light of theoretical considerations. This may indicate that there are differences in pharmacological activity between ropinirole and other dopaminergic agents such as pramipexole.
The Relationship Among Multiple Sclerosis–Related Symptoms, Sleep Quality, and Sleep Hygiene Behaviors
Authors: Newland Pamela , Lorenz Rebecca A. , Smith Judith M. , Dean Emily , Newland John , Cavazos Patricia 
Published: November 2018

ABSTRACT

Aims and Objectives: The aim of this study was to examine the relationships among multiple sclerosis (MS)–related symptoms, sleep hygiene behaviors, and sleep quality in adults with MS who self-report fatigue. Background: Fatigue is a frequent, prevalent symptom among adults with MS. Few studies have examined the relationship among fatigue and other symptoms with sleep quality and sleep behaviors. Design: This is a descriptive correlational study. Methods: A convenience sample of 39 adults with MS were recruited for the study. Instruments used included the revised MS Related Symptom Scale and the Pittsburgh Sleep Quality Index. Correlations examined the relationships among fatigue and other MS symptoms with sleep quality and sleep hygiene behaviors. Results: The frequency of several symptoms correlated with poor sleep quality, and fatigue frequency was higher in those who used electronic devices and practiced poor sleep hygiene behaviors. Nursing Implications: Nurses should incorporate interventions for symptoms that impact sleep quality. These findings suggest that sleep hygiene education should be a part of routine clinical care. Conclusion: Adults with MS experience the burden of many symptoms that impact sleep quality. Interventions that include education to improve symptoms, sleep hygiene behaviors, and sleep quality are needed.
Why Do Women Get Cervical Cancer in an Organized Screening Program in Canada?
Authors: Jackson Rebecca , Wang Li , Jembere Nathaniel , Murphy Joan , Kupets Rachel 
Published: November 2018

Objective
The aim of the study was to determine factors associated with the development of cervical malignancy among women participating in an organized cervical screening program.

Materials and Methods
A population-based retrospective cohort study was performed examining the screening histories 2 to 10 years before diagnosis of invasive cancer in Ontario women between 2011 and 2014.

Results
A total of 2,002 cases of cervical cancer were identified; 1,358 (68%) were squamous cell carcinomas and 644 (32%) were adenocarcinomas. The mean age at the time of diagnosis was 50.3 years. More than 60% of the cohort had at least 1 cytology test within 2 to 10 years of their diagnosis. Of the women having a cytology result 24 to 36 months before diagnosis, 69% had a normal cytology whereas only 7% had a high-grade cytology result. Stage of cancer was most advanced in women who did not have cytology in the 2 to 10 years before their diagnosis. On multivariate regression, those with cervical cancer who were less likely to have undergone screening include older age, advanced stage, lower income, not having a family physician, and those diagnosed with adenocarcinoma.

Conclusions
Although nonparticipation in screening is the greatest factor associated with cervical cancer diagnosis, failure of cervical cytology to detect cytologic abnormalities in women 2 to 3 and 3 to 5 years before diagnosis is of concern. Efforts must be directed to recruitment of women for screening as well as improving the sensitivity of screening tests to detect existing abnormalities.
Health-related quality of life in patients with chronic wounds before and after treatment with medical ozone
Authors: Izadi Morteza , Bozorgi Majedeh , Hosseine Mahboobeh Sadat , Khalili Nahid , Jonaidi-Jafari Nematollah 
Published: November 2018

Abstract
Ozone therapy has been used to treat numerous diseases. Indications of its therapeutic application are increasing, and evidence for its usefulness is growing. Evidence of its antibacterial and proliferative activity suggests its efficacy in treating chronic wounds. The current study evaluated the effect of ozone therapy on the health-related quality of life of patients with chronic wounds.
In the present cross-sectional study, the health-related quality of life was evaluated in 86 patients with chronic wounds undergoing ozone therapy. To measure quality of life, 2 previously established questionnaires were used, the Cardiff wound impact questionnaire and the SF-36 questionnaire. Questionnaires were completed through interviews with the patients.
A total of 86 patients with chronic wounds undergoing ozone therapy participated in this study. The mean age of participants was 58.91 years; 69.8% of them were male, 91.9% had diabetes mellitus, and 50% were receiving insulin therapy. Patients were under local (26.7%), systemic (9.3%), and local plus systemic (64%) protocols of ozone therapy. Mean overall quality of life reported by the patients was 6.2, and mean overall quality of life satisfaction was 6.02 (measured by the Cardiff Wound Impact Questionnaire). Mean physical quality of life measured by the SF-36 questionnaire was 39.12, and mean mental quality of life was 44.37 (measured by the same questionnaire). Among the included variables, the number of ozone therapy sessions was the strongest predictor of quality of life in both questionnaires and remained significant after different levels of adjustment.
In addition to the significant improvement observed in the healing of chronic wounds, medical O3 therapy has also shown to effect a significant improvement in the health-related quality of life of patients and could be a valuable therapeutic option in chronic wound cases.
Comparison of the diagnostic efficiency for local recurrence of rectal cancer using CT, MRI, PET and PET-CT
Authors: Shao Hongsheng , Ma Xueni , Gao Ya , Wang Jiancheng , Wu Jiarui , Wang Bo , Li Jipin , Tian Jinhui 
Published: November 2018

Abstract

Background:
The risk of local recurrence (LR) continues to threat patients with rectal cancer after surgery or chemoradiotherapy. The main reason is that there is frequently extensive scarring and reactive changes after radiotherapy and resection. Thus, the diagnosis of LR can be challenging. There are different imaging modalities that have been used in the follow-up of rectal cancer, including computed tomography (CT), magnetic resonance imaging (MRI), positron emission tomography (PET), and positron emission tomography-computed tomography (PET-CT) in clinical practice.

Methods:
We will systematically search PubMed, EMBASE, the Cochrane Library, and Chinese Biomedical Literature Database for diagnostic trials using CT, MRI, PET, and PET-CT to detect LR of rectal cancer in April, 2018. Two review authors will independently screen titles and abstracts for relevance, assess full texts for inclusion, and carry out data extraction and methodological quality assessment using the QUADAS-2 tool. We will use bivariate meta-analysis to estimate summary sensitivity, specificity, positive likelihood ratio, negative likelihood ratio, and diagnostic odds ratio of CT, MRI, PET, and PET-CT, as well as different sequences of MRI. For each index test, estimates of sensitivity and specificity from each study will be plotted in summary receive operating curve space and forest plots will be constructed for visual examination of variation in test accuracy. We will perform meta-analyses using the hierarchical summary receiver-operating characteristic model to produce summary estimates of sensitivity and specificity. Then, head-to-head and indirect comparison meta-analyses will be carried out.

Discussion:
This review will help determine the diagnostic accuracy of CT, MRI, PET, and PET-CT for the diagnosis of patients with LR of rectal cancer.

Ethics and dissemination:
Ethics approval and patient consent are not required, as this study is a systematic review.

PROSPERO registration number:
CRD42018104918.