bluuebunny/crossref_metadata_2025_split huggingface dataset:
Streamlined assessment of membrane permeability and its application to membrane engineering of Escherichia coli for octanoic acid tolerance
Authors: Santoscoy Miguel C , Jarboe Laura R 
Published: February 2019

Abstract
The economic viability of bio-production processes is often limited by damage to the microbial cell membrane and thus there is a demand for strategies to increase the robustness of the cell membrane. Damage to the microbial membrane is also a common mode of action by antibiotics. Membrane-impermeable DNA-binding dyes are often used to assess membrane integrity in conjunction with flow cytometry. We demonstrate that in situ assessment of the membrane permeability of E. coli to SYTOX Green is consistent with flow cytometry, with the benefit of lower experimental intensity, lower cost, and no need for a priori selection of sampling times. This method is demonstrated by the characterization of four membrane engineering strategies (deletion of aas, deletion of cfa, increased expression of cfa, and deletion of bhsA) for their effect on octanoic acid tolerance, with the finding that deletion of bhsA increased tolerance and substantially decreased membrane leakage.
Closure, credence and rationality: a problem for non-belief hinge epistemology
Authors: Jope Matt 
Published: February 2019

AbstractDuncan Pritchard’s Epistemic Angst promises a novel solution to the closure-based sceptical problem that, unlike more traditional solutions, does not entail revising our fundamental epistemological commitments. In order to do this, it appeals to a Wittgensteinian account of rational evaluation, the overarching theme of which is that it neither makes sense to doubt nor to believe in our anti-sceptical hinge commitments. The purpose of this paper is to show that the argument for the claim that there can be no rational basis to believe our anti-sceptical hinge commitments relies upon an implicit assumption about rational support that I label The Pritchensteinian Rational Grounds Principle. I argue that, insofar as this principle is intended to apply to closure-style inferences, it leads to irrational doxastic attitudes. I consider a seemingly plausible modification of the principle that would avoid this result but show that this modified principle faces serious problems of its own.
Joubert Syndrome: Two Different Prenatal Ultrasound Presentations
Authors: Shah Nupur 
Published: February 2019

AbstractJoubert syndrome is a rare brainstem malformation characterized by hypoplastic vermis, thickened and elongated superior cerebellar peduncles, abnormally shaped 4th ventricle which may be associated with renal, ocular, hepatic orodigitofacial and cranial abnormalities and can be diagnosed on prenatal ultrasound and now is considered a part of Joubert syndrome and related syndromes (JSRD). Two prenatally detected cases of JSRD presented here expand the spectrum of sonological signs which should prompt a fetal medicine specialist to suspect JSRD.
Harmonizing brain magnetic resonance imaging methods for vascular contributions to neurodegeneration
Authors: Smith Eric E. , Biessels Geert Jan , De Guio François , de Leeuw Frank Erik , Duchesne Simon , Düring Marco , Frayne Richard , Ikram M. Arfan , Jouvent Eric , MacIntosh Bradley J. , Thrippleton Michael J. , Vernooij Meike W. , Adams Hieab , Backes Walter H. , Ballerini Lucia , Black Sandra E. , Chen Christopher , Corriveau Rod , DeCarli Charles , Greenberg Steven M. , Gurol M. Edip , Ingrisch Michael , Job Dominic , Lam Bonnie Y.K. , Launer Lenore J. , Linn Jennifer , McCreary Cheryl R. , Mok Vincent C.T. , Pantoni Leonardo , Pike G. Bruce , Ramirez Joel , Reijmer Yael D. , Romero Jose Rafael , Ropele Stefan , Rost Natalia S. , Sachdev Perminder S. , Scott Christopher J.M. , Seshadri Sudha , Sharma Mukul , Sourbron Steven , Steketee Rebecca M.E. , Swartz Richard H. , van Oostenbrugge Robert , van Osch Matthias , van Rooden Sanneke , Viswanathan Anand , Werring David , Dichgans Martin , Wardlaw Joanna M. 
Published: February 2019

AbstractIntroductionMany consequences of cerebrovascular disease are identifiable by magnetic resonance imaging (MRI), but variation in methods limits multicenter studies and pooling of data. The European Union Joint Program on Neurodegenerative Diseases (EU JPND) funded the HARmoNizing Brain Imaging MEthodS for VaScular Contributions to Neurodegeneration (HARNESS) initiative, with a focus on cerebral small vessel disease.MethodsSurveys, teleconferences, and an in‐person workshop were used to identify gaps in knowledge and to develop tools for harmonizing imaging and analysis.ResultsA framework for neuroimaging biomarker development was developed based on validating repeatability and reproducibility, biological principles, and feasibility of implementation. The status of current MRI biomarkers was reviewed. A website was created atwww.harness‐neuroimaging.orgwith acquisition protocols, a software database, rating scales and case report forms, and a deidentified MRI repository.ConclusionsThe HARNESS initiative provides resources to reduce variability in measurement in MRI studies of cerebral small vessel disease.
Measuring the performance of the Mental Health Continuum-Short Form (MHC-SF) in a primary care youth mental health service
Authors: Donnelly A. , O’Reilly A. , Dolphin L. , O’Keeffe L. , Moore J. 
Published: February 2019

ObjectivesMental health is regarded as more than the absence of mental health difficulties, with clinical and research focus moving towards measurement of well-being. The Mental Health Continuum-Short Form (MHC-SF) was developed to assess overall and emotional, social and psychological well-being. Little is known about the use of the MHC-SF with young people engaging with mental health services. The current pilot study sought to examine the performance of the MHC-SF in an Irish primary care youth mental health service for 12–25 year olds.MethodsA sample of 229 young people (female n=143; male n=85, unknown n=1) aged 12–24 years (M=15.87, SD=2.51) who completed the MHC-SF prior to commencing their first intervention session in Jigsaw participated in this study. The psychometric properties of the MHC-SF were investigated using confirmatory factor analysis (CFA) and Cronbach’s alpha for internal consistency.ResultsCFA supported the three-factor structure of the MHC-SF for emotional, social, and psychological well-being, and very good internal consistency was observed.ConclusionFindings provide evidence for the psychometric properties of the MHC-SF in a primary care youth mental health setting, and suggest that the MHC-SF’s three-factor structure is valid for use in this context. Limitations and recommendations for future research are discussed.
MARKOV’S PRINCIPLE AND SUBSYSTEMS OF INTUITIONISTIC ANALYSIS
Authors: RAND MOSCHOVAKIS JOAN 
Published: February 2019

AbstractUsing a technique developed by Coquand and Hofmann [3] we verify that adding the analytical form MP1: $\forall \alpha (\neg \neg \exists {\rm{x}}\alpha ({\rm{x}}) = 0 \to \exists {\rm{x}}\alpha ({\rm{x}}) = 0)$ of Markov’s Principle does not increase the class of ${\rm{\Pi }}_2^0$ formulas provable in Kleene and Vesley’s formal system for intuitionistic analysis, or in subsystems obtained by omitting or restricting various axiom schemas in specified ways.
Effect of fruit and host fly species on the associative learning by Fopius arisanus
Authors: Monsia A. , Mègnigbèto G.S.B. , Gnanvossou D. , Karlsson M.F. 
Published: February 2019

AbstractParasitoids, released in augmentative biological control programmes, which display a rapid host-location capacity, have a higher likelihood of successfully controlling target pest species. By learning to associate sensory cues to a suitable oviposition site, might parasitoids used as biological control agents, locate hosts more rapidly, and perhaps increase the efficacity of e.g. Tephritidae fruit fly management. We studied associative learning of Fopius arisanus (Hymenoptera: Braconidae) and tested its range of learning in natural and conditional hosts and host fruits, i.e. Bactrocera dorsalis, Zeugodacus cucurbitae, Ceratitis capitata and Ceratitis cosyra (Diptera: Tephritidae) and on fruits (papaya, tomato, banana). Naïve female F. arisanus were compared with experienced wasps, which had been offered infested and non-infested fruit, and been allowed to oviposit. Preferences for olfactory cues from infested fruits were thereafter assessed in a two-choice olfactometer. Naïve and trained parasitoids preference differed in general and non-responders to infested fruits were higher among naïve parasitoids. The trained wasps preferred the fruit infested in the training more than the control fruit, for all combination, except when C. cosyra infested the fruits, hence avoidance behavioural response was observed towards the odour of the infested fruit. Fopius arisanus was capable of behaviourally respond to the learned information, e.g. associative odour learning was achieved, yet limited depending on interaction level, fruit fly and fruit combination. To create F. arisanus preference of an associated odour, it might hence be needed to ensure oviposition in perceived suitable host and host fruit, for the parasitoid learning to become favourable in a biological control setup.
A system dynamics modelling simulation based on a cohort of hepatitis B epidemic research in east China community
Authors: Yu Zhixin , Deng Min , Peng Chunting , Song Xue , Chen Yi , Zhang Xue , Liu Qiuxia , Li Yuchuan , Jiang Haiyin , Xu Xiaolan , Pan Liya , Yuan Jing , Ruan Bing 
Published: February 2019

AbstractHepatitis B constitutes a severe public health challenge in China. The Community-based Collaborative Innovation hepatitis B (CCI-HBV) project is a national epidemiological study of hepatitis B and has been conducting a comprehensive intervention in southern Zhejiang since 2009.The comprehensive intervention in CCI-HBV areas includes the dynamic hepatitis B screening in local residents, the normalised treatment for hepatitis B infections and the upcoming full-aged hepatitis B vaccination. After two rounds of screening (each round taking for 4 years), the initial epidemiological baseline of hepatitis B in Qinggang was obtained, a coastal community in east China. By combining key data and system dynamics modelling, the regional hepatitis B epidemic in 20 years was predicted.There were 1041 HBsAg positive cases out of 12 228 people in Round 1 indicating HBV prevalence of 8.5%. Of the 13 146 people tested in Round 2, 1171 people were HBsAg positive, with a prevalence of 8.9%. By comparing the two rounds of screening, the HBV incidence rate of 0.192 per 100 person-years was observed. By consulting electronic medical records, the HBV onset rate of 0.533 per 100 person-years was obtained. We generated a simulated model to replicate the real-world situation for the next two decades. To evaluate the effect of interventions on regional HBV prevalence, three comparative experiments were conducted.In this study, the regional hepatitis B epidemic in 20 years was predicted and compared with HBV prevalence under different interventions. Owing to the existing challenges in research methodology, this study combined HBV field research and simulation to provide a system dynamics model with close-to-real key data to improve prediction accuracy. The simulation also provided a prompt guidance for the field implementation.
THE ENDURING FORTRESS: THE INFLUENCE OF BRUNO BETTELHEIM IN THE POLITICS OF AUTISM IN FRANCE
Authors: BRIGGS JONATHYNE 
Published: February 2019

AbstractThis article examines how the work of Bruno Bettelheim remained influential in debates concerning the meaning of autism as well as its treatment in France well after it was marginalized in the United States. The persistence of Bettelheim's work among French audiences speaks to how the French understanding of autism diverged from its conception in the United States thanks to the social and cultural interest in psychoanalysis in French society and the perceived effectiveness of his form of treatment. The conflation between Bettelheim and the psychoanalytic approach to autism meant that advocates for other approaches needed to rebut his influences well into the 1980s and 1990s, which further reinforced his position as a prime representative for the problems of psychoanalysis for parents. The durability of Bettelheim's presence in these debates also underscores the perceived relationship between disability and motherhood in the case of autism and how Bettelheim buttressed that assumption for the French rooted in anxieties about the dangers of bad mothering. Bettelheim's ideas solidified the intersection of intellectual ascendance and social acceptance of psychoanalysis in France and anxieties about motherhood during the emergence of autism within the public discourse.
The relation of healthy and Western dietary patterns to the risk of endometrial and ovarian cancers: a systematic review and meta-analysis
Authors: Alizadeh Shahab , Djafarian Kurosh , Alizadeh Mohammad , Shab-Bidar Sakineh 
Published: February 2019

Abstract. Dietary patterns have been used to explore the association between dietary factors and risk of endometrial (EC) and ovarian cancer (OC); however, the results are inconclusive. This meta-analysis aimed to analyze these associations.Methods: Pertinent studies published prior to March 2016 were systematically searched. The common dietary patterns were selected and adjusted risk estimates were derived by comparing the highest with the lowest categories of dietary pattern scores.Results: A total of 8 studies, 5 for endometrial cancer (1 cohort and 4 case-control studies including 2617 cases and 78082 participants/controls) and 3 for ovarian cancer (1 cohort and 2 case-control studies with 2025 cases and 101482 participants/controls) were included in this meta-analysis. A lower risk of EC was shown for the highest compared with the lowest category of the healthy dietary pattern (OR = 0.84, 95% CI: 0.72–0.98; P for heterogeneity = 0.10), whereas the Western dietary pattern was related to the higher risk of EC (OR = 1.19, 95% CI: 1.01–1.41; P for heterogeneity = 0.35). No significant relationship was found between the healthy dietary pattern (OR = 1.03, 95% CI: 0.69–1.53; P for heterogeneity = 0.01) and OC, while, adherence to the western pattern was associated with a 73% higher risk of OC (OR = 1.73, 95% CI: 1.08–2.37; P for heterogeneity = 0.06).Conclusion: A Western dietary pattern might be associated with a higher risk of endometrial and ovarian cancer.
Vitamin E consumption and the risk of bladder cancer
Authors: Lin Jian-Hai , Chen Shao-Jun , Liu Huan , Yan Yang , Zheng Jun-Hua 
Published: February 2019

Abstract. Background: Vitamin E has anti-cancer properties, which was demonstrated mainly due to its antioxidant effect. Several epidemiological studies have investigated the association between vitamin E consumption and the risk of bladder cancer. However, the results were inconsistent. The meta-analysis study aimed to evaluate the association of vitamin E consumption and the risk of bladder cancer. Methods: We conducted a systematic literature search in the electronic databases, which included MEDLINE, EMBASE and the Cochrane Library till 1 January 2016. The pooled relative risk ratios (RRs) with 95% confidence intervals (CIs) were calculated depending on the heterogeneity among studies. Subgroup analysis and sensitivity analysis were also performed. Publication bias was assessed using Begg’s test and Egger’s test. Results: A total of 11 prospective studies (3 randomized clinical trials and 8 cohort studies) including 575601 participants were identified to be eligible for our present meta-analysis. The pooled RRs with 95% CI for highest versus lowest vitamin E consumption was 0.89 (0.78–1.00). An inverse linear association between vitamin E consumption and bladder cancer risk was detected in the dose response analysis. The results were also stable in the subgroup analysis and sensitivity analysis. Meanwhile, no obvious publication bias was observed. Conclusions: Our study indicates that vitamin E consumption was inversely associated with the risk of bladder cancer.
Field Measurements of Passive Earth Forces in Steep, Shallow, Landslide‐Prone Areas
Authors: Cislaghi Alessio , Cohen Denis , Gasser Eric , Bischetti Gian Battista , Schwarz Massimiliano 
Published: February 2019

AbstractPassive earth resistance plays an important role in slope stability analyses for predicting shallow landslide susceptibility. Three‐dimensional models estimate the contribution of this factor to slope stability using geotechnical theories designed for retaining structures and add it to the resistive forces. Systematic investigations have not been conducted to quantify this resistance in soils experiencing compression during the triggering of shallow landslides. This study presents field‐scale experimental data of passive earth force for cohesive and frictional clayey gravel evaluated at different combinations of soil depths and slopes. The experimental setup included a specialized device composed of a steel structure and a stiff plate that moved toward a mass of soil. In both dynamic and quasi‐static states, force‐displacement curves and maximum compression resistance were determined for several water content conditions induced by a rainfall simulator. The maximum dynamic force ranged from 8.49 to 31.67 kN for soil depths ranging between 0.36 and 0.50 m, whereas the quasi‐static force corresponded to 60% of the dynamic force. Furthermore, rainfall generated an additional decrease of compression resistance compared to that measured in the field. A comparison of measured data with theoretical models of passive earth force indicated that Rankine's solution provided the best estimate, whereas the logarithmic spiral approach significantly overestimated passive earth force by up to 70%. Therefore, the correct choice of geotechnical formulation or the direct use of field measurements to estimate passive earth force may significantly improve the accuracy of 3‐D limit equilibrium models for assessing slope stability over natural landscapes.
N2O Emissions From the Northern Benguela Upwelling System
Authors: Arévalo‐Martínez D. L. , Steinhoff T. , Brandt P. , Körtzinger A. , Lamont T. , Rehder G. , Bange H. W. 
Published: February 2019

AbstractThe Benguela Upwelling System (BUS) is the most productive of all eastern boundary upwelling ecosystems and it hosts a well‐developed oxygen minimum zone. As such, the BUS is a potential hotspot for production of N2O, a potent greenhouse gas derived from microbially driven decay of sinking organic matter. Yet, the extent at which near‐surface waters emit N2O to the atmosphere in the BUS is highly uncertain. Here we present the first high‐resolution surface measurements of N2O across the northern part of the BUS (nBUS). We found strong gradients with a threefold increase in N2O concentrations near the coast as compared with open ocean waters. Our observations show enhanced sea‐to‐air fluxes of N2O (up to 1.67 nmol m−2 s−1) in association with local upwelling cells. Based on our data we suggest that the nBUS can account for 13% of the total coastal upwelling source of N2O to the atmosphere.
First Identification of Late Permian Nb‐Enriched Basalts in Ailaoshan Region (SW Yunnan, China): Contribution From Emeishan Plume to Subduction of Eastern Paleotethys
Authors: Xu Jian , Xia Xiao‐Ping , Lai Chun‐Kit , Zhou Meiling , Ma Pengfei 
Published: February 2019

AbstractInteractions between ocean plate subduction and the nearby mantle plume represent a possible major drive for mantle heterogeneity. We first report Late Permian (~261 Ma) Nb‐enriched basalts (NEBs) in the Ailaoshan region. The Ailaoshan NEBs are characterized by high Nb (10.1–11.5 ppm) and Nb/La (1.2–1.3), positive Nb‐Ta anomalies and εNd(t) (+5.65 to +6.21), and low and mantle‐like zircon δ18O (5.28–5.75‰). Our results demonstrate that the source region contains an enriched mantle component, which may have derived from the nearby Emeishan plume. The Ailaoshan NEBs were possibly generated by mixing of subduction‐derived, mid‐ocean ridge basalt (MORB)‐like components and mantle plume‐derived, enriched components. We suggest that the Late Permian rollback of the Ailaoshan oceanic slab may have entrained the Emeishan plume material into the subduction zone, which caused compositional heterogeneity in the mantle wedge and formed the Ailaoshan NEBs.
Which Extratropical Cyclones Contribute Most to the Transport of Moisture in the Southern Hemisphere?
Authors: Sinclair V. A. , Dacre H. F. 
Published: February 2019

AbstractPredicted changes in Southern Hemisphere (SH) precipitation and Antarctic ice mass correspond to variations in the meridional moisture flux (MMF). Thirty‐five years of ERA‐Interim reanalysis data are combined with an extratropical cyclone (ETC) identification and tracking algorithm to investigate factors controlling SH MMF variability in the midlatitudes and near Antarctica. ETC characteristics which exert the strongest control on ETC MMF are determined thus identifying which ETCs contribute most to SH moisture transport. ETC poleward propagation speed exerts the strongest control on the ETC MMF across the Antarctic coastline. In SH winter, ETCs with the largest poleward propagation speeds transport 2.5 times more moisture than an average ETC. In the midlatitudes, ETC genesis latitude and poleward propagation speed have a similar influence on ETC MMF. Surprisingly, ETC maximum vorticity has little control on ETC MMF. Cyclone compositing is used to determine the reasons for these statistical relationships. ETCs generally exhibit a dipole of poleward and equatorward MMF downstream and upstream of the cyclone center, respectively. However, ETCs with the largest poleward propagation speeds resemble open frontal waves with strong poleward moisture transport downstream of the cyclone center only and thus result in the largest MMF. These results suggest that inhomogeneous trends and predicted changes in precipitation over Antarctica may be due to changes in cyclone track orientation, associated with changes to the large‐scale background flow, in addition to changes in cyclone number or intensity.
Global Occurrence and Chemical Impact of Stratospheric Blue Jets Modeled With WACCM4
Authors: Pérez‐Invernón F. J. , Gordillo‐Vázquez F. J. , Smith A. K. , Arnone E. , Winkler H. 
Published: February 2019

AbstractIn this work we present the first parameterizations of the global occurrence rate and chemical influence of Blue Jets, a type of transient luminous event taking place in the stratospheric region above thunderclouds. These parameterizations are directly coupled with five different lightning parameterizations implemented in the Whole Atmosphere Community Climate Model (WACCM4). We have obtained a maximum Blue Jet global occurrence rate of about 0.9 BJ per minute. The geographical occurrence of Blue Jets is closely related to the chosen lightning parameterization. Some previously developed local chemical models of Blue Jets predicted an important influence onto the stratospheric concentration of N2O, NOx, and O3. We have used these results together with our global implementations of Blue Jets in WACCM4 to estimate their global chemical influence in the atmosphere. According to our results, Blue Jets can inject about 3.8 Tg N2O‐N/year and 0.07 Tg NO‐N/year near the stratosphere, where N2O‐N and NO‐N stand for the mass of nitrogen atoms in N2O and NO molecules, respectively. These production rates of N2O and NOx could have a direct impact on, for example, the acidity of rainwater or the greenhouse effect. We have found that Blue Jets could also slightly contribute to the depletion of stratospheric ozone. In particular, we have estimated that the maximum difference in the concentration of O3 at 30 km of altitude between simulations with and without Blue Jets can be about −5% in equatorial and polar regions.