bluuebunny/crossref_metadata_2025_split huggingface dataset:
FEATURES OF CYTOKINE PROFILE IN PATIENTS WITH BRONCHIAL ASTHMA COMBINED WITH OBESITY
Authors: Antonyuk M. V. , Gvozdenko T. A. , Novgorodtseva T. P. , Vitkina T. I. , Geltser B. I. , Yurenko A. V. , Mineeva E. E. , Knyshova V. V. 
Published: December 2018

Combination of bronchial asthma (BA) and obesity is a difficult-to-control phenotype. Studies of inflammatory process with respect to severity of the disease are important for understanding the potential influence of obesity on the BA clinical course. The objective of this study was to determine cytokine profile in patients with mild BA combined with obesity. The study involved fifty-three patients with partially controlled mild BA. The patients were recruited as volunteers and signed an informed consent. The first observation group consisted of 27 asthma patients with normal body weight, the second observation group consisted of 26 patients with BA combined with obesity. A control group included 25 healthy volunteers. All the patients underwent clinical and laboratory examination in accordance with clinical standards for BA and obesity. The levels of TNFα, IL-2, IL-4, IL-6, IL-10 were evaluated in blood serum by means of flow cytometry. The ratios of proand anti-inflammatory cytokines (TNFα/IL-4, TNFα/IL-10, IL-6/IL-4, IL-6/IL-10) were calculated. Asthma patients with obesity (the 2nd group) had elevated levels of IL-2 over control group and group 1, by 38% and 44% respectively(p < 0.05). The concentration of proinflammatory cytokines TNFα and IL-6 was significanty increased in the both patient groups. Mean TNFα level was increased 2.5 times (p < 0.05), and IL-6 levels were increased by 30% (p < 0.05) in the 1st group as compared to the controls. TNFα and IL-6 concentrations showed a 3-fold increase over control values (p < 0.05) in the 2nd group. The level of antiinflammatory cytokine IL-4 was increased in patients with BA, independently of body mass. It should be noted that the concentration of this cytokine in obese patients was higher by 29% than in patients with normal body weight. IL-10 levels in patients from the 2nd group were reduced more than 2 times than in the 1st group. The patients of the 1st group showed a decrease in the IL-6/IL-10 index, in comparison with control parameters, thus indicative of an imbalance due to the elevation of the anti-inflammatory IL-10 cytokine. Among BA patients with obesity (group 2) the TNFα/IL-10 and IL-6/IL-10 indexes were higher than those of the control group (2.3- and 5.5-fold, respectively) and the group 1 (2.6- and 2.5-fold, respectively). Dynamics of these indexes confirms the systemic nature of inflammation and a predominance of non-atopic inflammation in asthma patients with obesity. Thus, features of the cytokine profile in BA with obesity consist of a significant increase in pro-inflammatory IL-2, IL-6, TNFα cytokines, and a relative decrease in anti-inflammatory IL- 10 cytokine. The development of BA with obesity, even in mild-severity BA, is accompanied by development of a cytokine disbalance, which is typical for a mixed-type inflammation, with a prevalence of neutrophil inflammation.
Neoadjuvant FOLFIRINOX for Patients with Borderline Resectable or Locally Advanced Pancreatic Cancer: Results of a Decision Analysis
Authors: Choi Jin G. , Nipp Ryan D. , Tramontano Angela , Ali Ayman , Zhan Tiannan , Pandharipande Pari , Dowling Emily C. , Ferrone Cristina R. , Hong Theodore S. , Schrag Deborah , Fernandez-Del Castillo Carlos , Ryan David P. , Kong Chung Yin , Hur Chin 
Published: December 2018

Abstract

Background
The effectiveness and cost-effectiveness of using neoadjuvant FOLFIRINOX (nFOLFIRINOX) for patients with borderline resectable or locally advanced pancreatic ductal adenocarcinoma (BR/LA PDAC) are unknown. Our objective was to determine whether nFOLFIRINOX is more effective or cost-effective for patients with BR/LA PDAC compared with upfront resection surgery and adjuvant gemcitabine plus capecitabine (GEM/CAPE) or gemcitabine monotherapy (GEM).

Materials and Methods
We performed a decision-analysis to assess the value of nFOLFIRINOX versus GEM/CAPE or GEM using a mathematical simulation model. Model transition probabilities were estimated using published and institutional clinical data. Model outcomes included overall and disease-free survival, quality-adjusted life-years (QALYs), cost in U.S. dollars, and cost-effectiveness expressed as an incremental cost-effectiveness ratio. Deterministic and probabilistic sensitivity analyses explored the uncertainty of model assumptions.

Results
Model results found median overall survival (34.5/28.0/22.0 months) and disease-free survival (15.0/14.0/13.0 months) were better for nFOLFIRINOX compared with GEM/CAPE and GEM. nFOLFIRINOX was the optimal strategy on an efficiency frontier, resulting in an additional 0.35 life-years, or 0.30 QALYs, at a cost of $46,200/QALY gained compared with GEM/CAPE. Sensitivity analysis found that cancer recurrence and complete resection rates most affected model results, but were otherwise robust. Probabilistic sensitivity analyses found that nFOLFIRINOX was cost-effective 92.4% of the time at a willingness-to-pay threshold of $100,000/QALY.

Conclusion
Our modeling analysis suggests that nFOLFIRINOX is preferable to upfront surgery for patients with BR/LA PDAC from both an effectiveness and cost-effectiveness standpoint. Additional clinical data that further define the long-term effectiveness of nFOLFIRINOX are needed to confirm our results.
La ciudad pervertida/Urbanismo neoliberal, negocio inmobiliario y vida vecinal
Authors: Pujades Joan Josep 
Published: December 2018

Ressenya dels llibres: Cucó, Josep (Comp.) (2013), La ciudad pervertida. Una mirada sobre la Valencia global. Barcelona, Anthropos.Franquesa, Jaume (2013), Urbanismo neoliberal, negocio inmobiliario y vida vecinal. El caso de Palma. Barcelona, Icaria.
Chrisman, N. y T. Maretzky: Clinically Applied Anthropology
Authors: Comelles Josep Maria 
Published: December 2018

Clinically Applied Anthropology pertenece a la ya prestigiosa colección «Culture, Illness and Healing», dirigida por Arthur Kleinman y que publica el editor neerlandés D. Reidel. Es un texto que enlaza con el que comentamos en AEC 2, The Relevance of Social Science for Medicine, y que como aquél abre las perspectivas metodológicas y teóricas hacia una Antropología de la Medicina aplicada a los sistemas sanitarios occidentales. Y aunque el libro a que hacemos referencia se basa en textos relativos a la praxis asistencia norteamericana, dada la dependencia ideológica de muchas de las formas de nuestra organización sanitaria respecto a aquélla el libro es igualmente útil a un público español.
Petonet, C.: On est tous dans le brouillard i Espaces habit
Authors: Comas d'Argemir Dolors 
Published: December 2018

Els dos llibres que comentem constitueixen un sol treball, malgrat la separació en el temps de llur publicació. Efectivament, Espaces habités és una versió ampliada d'un capítol de l'altra obra, del capítol que ofereix, potser, un interès intrínsec més gran. Ambdós llibres tenen un mateix subtítol, «Ethnologie des banlieues», que clarifica, de fet, llur contingut, ja que els títols (metafòric l'un, i molt general l'altre) no el permeten identificar d'un cop d'ull. Però cal especificar més encara: en el pensament de l'autora els llibres no es situen tant en el camp de l'Antropologia urbana com, més aviat, en el d'una Antropologia de les societats complexes; no tracta de fer un estudi de la ciutat, sinó un estudi a la ciutat, essent en aquest marc comprensiu ampli (estudi etnològic a la ciutat en el context d'una societat complexa) on cal situar la part que retalla l'autora: els barris on habita el subproletariat, que és l'objecte del seu interès i anàlisi.
El modelo médico hegemónico: transacciones y alternativas hacia una fundamentación teórica del modelo de autoatención en salud
Authors: Menéndez Eduardo L. 
Published: December 2018

En dos trabajos previos (E. L. Menéndez, 1978 y 1980) hemos tratado de caracterizar la estructura del modelo médico, así como el proceso contradictorio que el desarrollo del mismo supone. En otros dos materiales hemos tratado de demostrar a nivel empírico la incidencia de los procesos de automedicación, por lo menos para el contexto mexicano (E. L. Menéndez, 1981a y 1982). En este trabajo retomaremos algunos de los conceptos planteados para analizar en particular una de las principales áreas que surge en el proceso de expansión actual del modelo médico hegemónico, y que conforma una potencial alternativa al mismo.
Psicosis en Familia: Acerca de un Caso de Folie à Deux en un Pueblo del Baix Camp a Tarragona
Authors: Allué Beatriz , Pérez Empar 
Published: December 2018

En nuestra experiencia clínica, nos llama la atención la gran incidencia de familias, en las que las psicosis afectan a varios miembros. Ante el ingreso en nuestra institución psiquiátrica de un caso de folie à deux entre una madre y su hijo, nos planteamos la revisión bibliográfica del concepto y el estudio del caso.
Spanish Folk Medicine in Discussion: the Body Concept
Authors: Kuschik Ingrid 
Published: December 2018

The study on "folk medicine" or "popular medicine" in Spain deals with practices and concepts which are present in contemporary Spain. It tries to analyze some traits of its practices by including historical and regional comparative aspects. Using the examples of popular concepts of illness (as mal de ojo, mal aire, brujería)its folkloristics and sociocultural connections are analyzed.
Vejez y cultura: Hacia los límites del sistema, por Teresa Sanromán
Authors: García Montserrat 
Published: December 2018

Actualmente se editan pocos libros científicos que tengan en su haber un estudio anterior profundo y extenso del tema al cual se dirigen, a no ser que tengamos en nuestras manos el resultado de una tesis doctoral a la que precedan varios años de investigación. Y aún así. Una tesis suele ofrecer la elaboración teórica y las conclusiones a las que se llega tras el análisis de unos datos obtenidos después de un estudio que comprende cierto tiempo de investigación. Vejez y cultura. Hacia los límites del sistema aparece como propuesta teórica de una nueva línea de investigación en los estudios que se desarrollan en el momento actual en el ámbito de la ancianidad. Una propuesta que nos ofrece su autora, Teresa San Román, con una sólida base de más de 15 años de trabajo de campo en el marco de los estudios sobre marginación social concretamente entre minorías étnicas (gitanos). Ella misma afirma que "...Para poner a prueba las hipótesis formuladas a partir del trabajo con gitanos, "era necesario" buscar otro colectivo marginado paro que tuviera características muy diferentes, contrapuestas a ser posible, a las de los gitanos. Por eso, entre otras razones, he elegido el estudio de los ancianos..." (San Román, 1986: 123).
Gnosis
Authors: De la Parte Isabel 
Published: December 2018

El Movimiento Gnóstico se funda en México, en la década de los 60. Víctor Manuel Gómez, conocido como Samael Aun Weor es el creador de un pensamiento fundamentado en la ciencia, el arte, la religión y la filosofía extraídas de todas las civilizaciones y culturas pasadas y contemporáneas. Este saber le ha sido transmitido a través de sus experiencias místicas y de la lectura e interpretación de diversas publicaciones esotéricas, donde se recogen pensamientos teosóficos y rosacrucis. También la “Pistis Sophia" es fuente de conocimiento para Samael durante su juventud.
Presentació
Authors: Arxiu Revista 
Published: December 2018

Aquests dos volums monogràfics d'Arxiu d'Etnografia de Catalunya que el lector té a les mans recullen un primer resultat de la tasca duta a terme per un dels equips de treball del Departament d'Antropologia Social i Filosofia de la Universitat Rovira i Virgili de Tarragona. La investigació ha estat programada en el marc de l'Arxiu d'Etnografia de Catalunya, institució en la qual els antropòlegs tarragonins integrem les nostres recerques, individuals i col·lectives.
Itineraris religiosos: vocacions i vocacions alternatives
Authors: Juncosa Magda 
Published: December 2018

Es una creença força generalitzada en els estudis sobre sectarisme que existeixen uns trets biogràfics específics que impulsen determinats individus a fer-se membres d'una secta. L'autora revisa aquesta hipòtesi i aprofundeix en el tema basant-se en l'anàlisi de dotze biografies concretes. Alguns del itineraris religiosos dels informants són “ortodoxos”, mentre que els altres cauen de ple en els estereotips percebuts com a “sectaris”.Es una creencia bastante generalizada en los estudios sobre sectarismo, que existen unos rasgos biográficos específicos que impulsan a determinados individuos a hacerse miembros de alguna secta. La autora revisa esta hipótesis y profundiza en el tema basándose en el análisis de doce biografías concretas. Algunos de los itinerarios religiosos de los informantes son “ortodoxos”, mientras que otros se insertan en los estereotipos percibidos como sectarios.It is a highly generalized belief in studies on sectarianism, that particular biographical traits exist which stimulate certain individuals to become members of a sect. The author revises this hypothesis and makes a more in depth study of the theme, based on the analysis of twelve specific biographies. Some of the religious itineraries of the informants are "orthodox" whilst others fall directly within the stereotypes perceived as "sectarian".Dans les études sur le sectarisme, on exprime très souvent l'idée suivant laquelle il existeraient des traits biographiques spécifiques qui conduiraient certains individus à devenir membres d'une secte. L'auteur passe en revue cette hypothèse et examine le problème à partir de l'analyse de douze récits biographiques. On peut qualifier un certain nombre de ces itinéraires religieux d'«orthodoxes», tandis que les autres relèvent plutôt des stéréotypes classiques qui contribuent à la construction de l'image du «sectaire».
Presentació
Authors: Prat Joan 
Published: December 2018

Aquests dos volums monogràfics d'Arxiu d'Etnografia de Catalunya que el lector té a les mans recullen un primer resultat de la tasca duta a terme per un dels equips de treball del Departament d'Antropologia Social i Filosofia de la Universitat Rovira i Virgili de Tarragona. La investigació ha estat programada en el marc de l'Arxiu d'Etnografia de Catalunya, institució en la qual els antropòlegs tarragonins integrem les nostres recerques, individuals i col·lectives.
Kolon polipleri ve diyet ilişkisi
Authors: ŞAHİNTÜRK Yasin , ÇEKİN Ayhan Hilmi 
Published: December 2018

Giriş ve Amaç: Diyet alışkanlıkları ve
spesifik besin gruplarının kolon polip gelişimi, histolojisi ve boyutları
üzerindeki etkisinin aydınlatılması. Gereç
ve Yöntem: 2012-2015 yılları arasında kolonoskopi yapılan 1004 hasta
beslenme alışkanlıkları yönünden prospektif olarak değerlendirildi. Hastalar
kolon polibi var-yok, kolon polibi olanlar ise hiperplastik-adenomatöz, &lt;1 cm - &gt;1 cm olarak sınıflandırıldı ve
gruplar arası diyet alışkanlıklarının farkları incelendi. Bulgular: Çalışmamızda kolon polip gelişmesini; yaş, erkek
cinsiyet, kırmızı et ve bulgur tüketimi arttırırken, domates tüketimi
azaltmaktadır. Adenomatöz histoloji görülme sıklığını artıran faktörler yaş ve
bulgur tüketimi olarak saptanırken; azaltan faktörler ise yumurta ve pirinç
tüketimindeki artış olarak saptanmıştır. Kolon polip boyutlarını ise sadece
bulgur tüketimindeki artışın etkilediği saptanmıştır. Sonuç: Kolonda polip gelişimi, adenomatöz histoloji varlığı ve 1 cm’den
büyük polip gelişimi şeklinde bu üç kolorektal kanser risk faktörünü de artıran
tek besin maddesi bulgur olarak saptanmıştır. Bulgurun tüketim şekli, sıklığı
ve kolon kanseri saptanan hastaların geçmiş dönemdeki bulgur tüketimleri
ayrıntılı sorgulanmalı ve konuyla ilgili daha ayrıntılı çalışmalar
yapılmalıdır.
Kronik hepatitli ve karaciğer sirozlu hastaların biyoelektrik impedans yöntemi ile değerlendirilmesi
Authors: NAR Haşim , KIRHAN İdris , TAŞKIRAN Hüseyin , UYANIKOĞLU Ahmet , YENİCE Necati 
Published: December 2018

Giriş ve Amaç: Bu çalışmada, kronik hepatitli,
sirozlu ve sağlıklı bireyler arasında biyoelektriksel impedans analiz yöntemi
ile fark olup olmadığının araştırılması amaçlanmıştır.&nbsp;Gereç ve Yöntem: Çalışmaya Haziran 2012-2013 tarihleri arasında Harran Üniversitesi Tıp Fakültesi, Gastroenteroloji
polikliniğinde takip edilen 31 kronik hepatit B ve kronik hepatit C hastası, 35
karaciğer sirozu ve 38 sağlıklı erişkin alındı. Olgular kronik hepatit,
karaciğer sirozu ve sağlıklı kontrol olarak üç gruba ayrıldı. Olguların yaş,
cinsiyet, boy, kilo, hematokrit, sodyum, potasyum değerleri ve biyoelektriksel
impedans analiz ölçümü sonrası elde edilen değerler kaydedildi ve istatistiksel
analiz yapıldı.&nbsp;Bulgular: Siroz grubunun hematokrit ve
sodyum değeri anlamlı olarak düşüktü (p &lt;0.05). Vücut kapasitans değeri
kronik hepatitli grupta ve siroz grubunda kontrol grubuna göre yüksekti (p &lt;0.05).
Kronik hepatitli grupta rezistans kontrol grubuna göre düşüktü (p &lt;0.05).
Vücut hücre kitlesi kronik hepatitli grupta kontrol grubuna göre yüksekti (p &lt;0.05).
Kronik hepatitli grupta bazal metabolik hız kontrol grubuna göre yüksekti (p &lt;0.05).
Kronik hepatitli grubun yağsız vücut kitlesi kontrol grubuna göre yüksekti (p &lt;0.05).
Kronik hepatitli grubun intrasellüler sıvı ve total vücut suyu kontrol grubuna göre
yüksekti (p &lt;0.05). Faz açısı kronik hepatitli grupta diğer gruplara göre
yüksek olsa da istatistiksel olarak anlamlı değildi (p &gt;0.05).&nbsp;Sonuç: Biyoelektriksel
impedans analiz ile sirotik grupta, kontrol ve kronik hepatitli grupla
karşılaştırıldığında anlamlı bir değişiklik saptanmamasına rağmen kronik
hepatitli grupta saptanan değişiklikler biyoelektriksel impedans analiz açısından
ilerisi için ümit vericidir.
Path – Dependence and European Fisheries Management
Authors: Martín Palmero Federico , González Laxe Fernando 
Published: December 2018

For a long time there has been an attempt to explain the current crisis in the fisheries sector in terms of a confrontation between those defending “fish” and those defending “fishermen”. However, the real problem concerns the governance of fisheries and how common resources are assigned; it is not just a crisis of resources per se. Therefore, an insightful understanding of the scenario leading to a satisfactory solution is more complex than it is often believed since there is a need to tackle problems related to the state of stocks, fishermen’s strategies and ecosystems. The fishing sector is not exclusively concerned with production activities as some analysts would have us believe. Rather, it is an area that integrates a number of important features and requires different approaches dealing with the industrial aspects of the sector, distribution and consumption. The fishing sector is characterised by a high level of public intervention, in terms of regulation, finance and state subsidies. The plethora of norms has become such that, currently, the main areas of debate are those concerning how best to preserve resources and ecosystems (by managing and sustaining certain economic levels for example), the welfare of those who make their living from fishing, and the social impact on coastal communities among others. The main focus of debate used to be the conditions of access to fishing and fisheries. Nowadays, however, since early 2000s, efforts have concentrated on the limits of biological safety in order to guarantee sustainable and efficient fishing.This work carries out a dual analysis of the objectives of fisheries management. The first focuses on path dependence and the second on a debate among the three main players and their changing views. This approach allows us to clarify the different interests as regards policy-making, as well as to clearly define the different management implementation.
OFERTA DE PROTEÍNA E SÓDIO DOS PRATOS PROTEICOS EM REFEIÇÕES DE UMA UNIDADE DE ALIMENTAÇÃO
Authors: Villa Stela Dos Reis , Melo Vanessa , Spinelli Mônica Glória Neumann 
Published: December 2018

Objetivo avaliar a oferta de proteína e sódio dos pratos proteicos escolhidos na refeição almoço em uma de Unidade de Alimentação e Nutrição (UAN). Metodologia: Foi realizado um estudo observacional descritivo com comensais em um restaurante de uma UAN do município de São Paulo - SP. A refeição almoço desta unidade oferece diariamente dois pratos proteicos. O cálculo do número de porções dos dois pratos e de sua quantidade em gramas foi obtido pela média das escolhas dos pratos. Foram calculados a quantidade de proteínas, seu valor calórico e a quantidade de sódio, proporcionados pelos pratos proteicos escolhidos. Os resultados foram comparados com os valores recomendados pelo Programa de Alimentação do Trabalhador (PAT). Resultados: Os clientes se serviram em média com 1,12 porção do alimento preparado na UAN e com 1,51 de processados. A porção média escolhida do prato proteico foi de 295,53 g variando entre 146,00 e 462,70 g. A quantidade em gramas de proteína variou entre 37,51 g e 111,23 g e a de sódio entre 803,68 mg e 2188,10 mg. Conclusão: Nos dias analisados na UAN, o porcionamento dos pratos proteicos excedeu às recomendações, e a quantidade média de proteínas e de sódio das escolhas proteicas na refeição almoço ultrapassa o valor máximo recomendado pelo PAT, indicando que a livre demanda pode ser fator de risco para escolhas saudáveis.
Predictors in profile of referred newborns for their outcome in a tertiary newborn referral facility
Authors: Verma Avadhesh , Gaur Ajay , Ambey Ravi 
Published: December 2018

Background: This study was aimed to assess newborn referral and factors contributing to outcome of referred newborns.Methods: This prospective observational study was conducted in a tertiary newborn referral facility for a period of one year. Referred newborns fulfilling inclusion criteria were enrolled in study, and assessed in terms of demographic profile, transport characteristics, physiological variables. Investigations, management of neonatal illness was done as per standard management protocols, they were followed up to their outcome.Results: Out of 2000 enrolled referred newborns, 30.10% were expired. Mean gestational age for survived newborns was 36.54±2.92 (SD) weeks, for expired newborns 35.24±3.99 (SD) weeks. Mean weight for survived newborns 2312.27 gms ±555.71 (SD), for expired newborns 1936.71 gms ±665.67 (SD). Out of total 60.05% newborns transported from periphery, had higher mortality i.e. 35% as compared to newborns transported from urban place i.e. 25%. Mean transport duration for survived newborns 61.94 minutes ±55.18 (SD), for expired newborns 89.51 minutes ±88.94 (SD). Prolonged CRT was observed in 57.45% newborns, grunting 19.70%, Cyanosis 11%, gasping 7.6%, apnea 5%, respiratory distress 39.80%, hypothermia 74.95%, and 25.50% required resuscitation on admission. Unattended delivery, self-arranged mode of transport, prolonged CRT, respiratory distress, apnea , hypothermia on admission, weight on admission(<1500gms), hypoglycaemia and duration of transport more than 1 hour found statistically significant independent variables associated with mortality of referred newborns.Conclusions: A significant number of neonatal deaths can be prevented, if referral system is structured and organized. Improper referral leads to poor physiological profile of referred newborns, which leads to their poor outcome. There are many independent variables which are affecting the outcome of referred newborns. These independent variables can be taken care in holistic way once the referral system is cultured and nurtured in existing health system.