bluuebunny/crossref_metadata_2025_split huggingface dataset:
Stable Iron Hydroxide Nanosheets@Cobalt‐Metal–Organic–Framework Heterostructure for Efficient Electrocatalytic Oxygen Evolution
Authors: Gao Zhi , Yu Zhi Wu , Liu Feng Qing , Yang Chuo , Yuan Ya Hong , Yu Yi , Luo Feng 
Published: August 2019

AbstractMost studies are devoted to the use of metal–organic frameworks (MOFs) as templates to construct desirable electrocatalysts in situ by high‐temperature pyrolysis. The emergence of heterostructures invokes new opportunities to use the full potential of pristine MOFs as efficient catalysts in the oxygen evolution reaction (OER). Here, a MOF surface‐reaction strategy is developed to synthesize MOF‐based heterostructures without pyrolysis. Uniform Fe(OH)3 nanosheets are grown controllably on the Co‐MOF‐74 surface by a fast “phenol–Fe” reaction that takes advantage of the hydroxyl sites in Co‐MOF‐74. The resulting Fe(OH)3@Co‐MOF‐74 heterostructure delivers an excellent performance in the OER with a low overpotential of 292 mV at 10 mA cm−2. Notably, the introduction of Fe can improve the intrinsic activity of the original Co atom significantly. The turnover frequency in Fe(OH)3@Co‐MOF‐74 (1.209 s−1) is more than 25 times higher than that in Co‐MOF‐74 (0.048 s−1). This work presents a fresh concept for the fundamental design of advanced pure‐MOF‐based heterostructures and, thereby, provides a new avenue for the fabrication of other energy‐conversion and ‐storage materials.
Reversible Intercalation of Multivalent Al3+ Ions into Potassium‐Rich Cryptomelane Nanowires for Aqueous Rechargeable Al‐Ion Batteries
Authors: Joseph Jickson , Nerkar Jawahar , Tang Cheng , Du Aijun , O'Mullane Anthony P. , Ostrikov Kostya (Ken) 
Published: August 2019

AbstractInvited for this month's cover is a collaborative research effort involving Prof. Aijun Du, Mr. Cheng Tang, Prof. Kostya (Ken) Ostrikov, Prof. Anthony O'Mullane, Mr. Jickson Joseph, and Dr. Jawahar Nerkar at the Commonwealth Scientific and Industrial Research Organisation and Queensland University of Technology, Australia. The Full Paper itself is available at 10.1002/cssc.201901182.
The responsiveness and interpretability of psychosocial patient‐reported outcome measures in chronic musculoskeletal pain rehabilitation
Authors: Pulles Alexandra N. T. D. , Köke Albère J. A. , Strackke Robin P. , Smeets Rob J. E. M. 
Published: August 2019

AbstractBackgroundFor several widely used patient‐reported outcome measures (PROMs) in chronic musculoskeletal pain (CMSP) rehabilitation, it is still not known whether they are responsive to change, and what the smallest detectable change (SDC) and minimal clinically important change (MCIC) are. Knowledge of these values can be used to accurately interpret change scores in research and clinical practice.MethodsIn this retrospective cohort study, the responsiveness, the SDC and the MCIC of the mental components of the Research and Development 36‐Item Health Survey (RAND‐36), the Pain Catastrophizing Scale (PCS) and the Tampa Scale of Kinesiophobia (TSK) were investigated in CMSP patients. Responsiveness, the SDC and MCIC were determined by using both anchor and distribution‐based methods.ResultsFor all outcome measures, there was a progression from smallest to largest mean change scores between participants who did not perceive change and those who reported change after treatment. However, correlations of the Global Perceived Effect (GPE) with the change scores on the outcome measures were low. For all outcome measures, the SDC was larger than the MCIC.ConclusionsFor this population, the questionnaires were shown not to be responsive. Furthermore, the questionnaires appeared not to be able to distinguish clinically important change from measurement error in individual patients. The finding of large measurement errors of PROMs is in line with previous research in pain rehabilitation. Using generic PROMs only, to examine changes in psychosocial status due to a pain rehabilitation programme, is therefore questionable.SignificanceThis study shows that widely used generic psychosocial PROMs might not be responsive and not able to distinguish clinically important change from measurement error in individual chronic musculoskeletal pain patients. It therefore seems reasonable to reconsider the (compulsory) use of these PROMs for assessing the quality of pain rehabilitation programmes, and necessary to consider other, more objective, outcome measures for this purpose in this population.
Catalytic Activity of Anisotropic Gold Nanoplates towards Oxygen Reduction
Authors: Opuchlik Lidia Jagoda , Kizling Michal , Bacal Pawel , Bilewicz Renata 
Published: August 2019

AbstractGlassy carbon electrode (GCE) coated with anisotropic gold nanoplates (aAuNPs) was used for the study of oxygen reduction reaction (ORR) in 0.5 M sulfuric acid instead of bulk gold electrodes. The electrode cleaning/activation procedure lead to the removal of any charged and uncharged residues on the gold nanoplates, leaving the nanostructured surface highly active towards oxygen reduction. The advantages: much lower overpotential and larger current densities of oxygen reduction are ascribed to the unique nanostructures present on the carbon electrode surface‐the gold nanoplates. They are rich in edges providing a large population of Au (100) sites with unsaturated coordination exposed to the solution, and catalytically active. Measurements performed using a rotating disc electrode, modified with the gold nanoplates, confirmed that ORR proceeds via two separate steps: oxygen is reduced to hydrogen peroxide, and the peroxide is further reduced in a two‐electron reduction to water.
Indirect CE‐UV detection for the characterization of organic and inorganic ions of a broad mobility and pKa range in engine coolants
Authors: Rösch Tobias , Troffer Johann , Huhn Carolin 
Published: August 2019

AbstractAn alternative CE‐(indirect ultraviolet) method for the analysis of inorganic and organic anions in ethylene glycol‐based engine coolants is presented using a BGE with 4 mM pyromellitic acid and 3.4 mM 1,6‐hexamethylene diamine, pH 3. Baseline separation of six inorganic (e.g. nitrite, nitrate, and sulfate) and five organic anions (e.g. acetic and glycolic acid) was achieved. Quantification of 8 out of 11 specified anions was possible in stressed engine coolant samples after simple aqueous dilution. LODs between 0.8 and 15.1 mg/L with RSD values of peak areas between 2.6 and 11.9% were obtained. Some limitations due to matrix effects can be overcome with slight adaptations of the BGE. The flexibility of the method is vital regarding the increasing demands for the composition of engine coolants for pollution reduction.
Quantitative CE analysis of punicalagin in Combretum aculeatum extracts traditionally used in Senegal for the treatment of tuberculosis
Authors: Diop ElHadji Assane , Jacquat Jenna , Drouin Nicolas , Queiroz Emerson Ferreira , Wolfender Jean‐Luc , Diop Tahir , Schappler Julie , Rudaz Serge 
Published: August 2019

AbstractMycobacterium tuberculosis is the causative agent of tuberculosis, an infectious bacterial disease, which most commonly affects the lungs. In the search for novel active compounds or medicines against tuberculosis, an ethnopharmacological survey combined with a host‐pathogen assay has recently highlighted the potency of an aqueous extract of Combretum aculeatum. C. aculeatum is used in traditional medicine and has demonstrated a significant in vitro antimycobacterial activity. Punicalagin, an ellagitannin, was isolated and found to be related to the biological activity of the extract. An analytical method for the evaluation of punicalagin in C. aculeatum was developed by capillary electrophoresis. After method optimization, the quantification of punicalagin was achieved for the evaluation of various plant extracts to determine the content of punicalagin related to the extraction modes and conditions, origin of the plant material, and harvesting period. The developed method demonstrated that the leaves presented the highest punicalagin content compared to the seeds and stems. A decoction of 30 min in boiling water was found to be the best extraction mode of C. aculeatum.
The Impact of Pesticides on Flower-Visiting Insects: A Review with Regard to European Risk Assessment
Authors: Uhl Philipp , Brühl Carsten A. 
Published: August 2019

Abstract
Flower-visiting insects (FVIs) are an ecologically diverse group of mobile, flying species that should be protected from pesticide effects according to European policy. However, there is an ongoing decline of FVI species, partly caused by agricultural pesticide applications. Therefore, the risk assessment framework needs to be improved. We synthesized the peer-reviewed literature on FVI groups and their ecology, habitat, exposure to pesticides, and subsequent effects. The results show that FVIs are far more diverse than previously thought. Their habitat, the entire agricultural landscape, is potentially contaminated with pesticides through multiple pathways. Pesticide exposure of FVIs at environmentally realistic levels can cause population-relevant adverse effects. This knowledge was used to critically evaluate the European regulatory framework of exposure and effect assessment. The current risk assessment should be amended to incorporate specific ecological properties of FVIs, that is, traits. We present data-driven tools to improve future risk assessments by making use of trait information. There are major knowledge gaps concerning the general investigation of groups other than bees, the collection of comprehensive data on FVI groups and their ecology, linking habitat to FVI exposure, and study of previously neglected complex population effects. This is necessary to improve our understanding of FVIs and facilitate the development of a more protective FVI risk assessment. Environ Toxicol Chem 2019;38:2355–2370. © 2019 The Authors. Environmental Toxicology and Chemistry published by Wiley Periodicals, Inc. on behalf of SETAC
A dynamic swift association scheme for wireless body area networks
Authors: Sheraz Adil , Bangash Javed Iqbal , Khan Abdul Waheed , Imran Muhammad , Khan Asfandyar , Khan Abdullah , Ishaq Muhammad , Khan Wajid Ullah 
Published: August 2019

AbstractAmong numerous promising applications of wireless sensor networks is wireless body area networks. Wireless body area networks are used for real‐time vital signs monitoring of patients in a remote setting. In addition to their dedicated sensing tasks, the implanted sensor nodes need to effectively utilize their resources to enhance the lifetime of the network. For wireless body area networks, IEEE 802.15.4 low data rate low‐power wireless Personal Area Networks (PANs) standard is adopted. The said standard uses fixed superframe structure operation, which restricts the movement of the nodes, and has degraded performance in the mobility of nodes. Two superframe parameters, ie, beacon order and superframe order, decide the beacon interval and duty cycle of the standard. Both beacon order and superframe order have a strong impact on the performance of network parameters. In this research work, a dynamic swift association scheme is proposed to enhance the performance of a mobile node with a scenario where node moves from its parent PAN and joins the neighbor PAN. Dynamic swift association scheme is compared with IEEE 802.15.4 in terms of association time, association success rate, average throughput, and energy consumption. Simulation results using network simulator version 2 confirm superior performance of dynamic swift association scheme against IEEE 802.15.4 standard.
Identification of new hypoxia‐regulated epithelial‐mesenchymal transition marker genes labeled by H3K4 acetylation
Authors: Wang Jian‐Qiu , Yan Feng‐Qin , Wang Li‐Hui , Yin Wen‐Juan , Chang Ting‐Yu , Liu Jun‐Ping , Wu Kou‐Juey 
Published: August 2019

AbstractHypoxia‐induced epithelial‐mesenchymal transition (EMT) involves the interplay between chromatin modifiers histone deacetylase 3 (HDAC3) and WDR5. The histone mark histone 3 lysine 4 acetylation (H3K4Ac) is observed in the promoter regions of various EMT marker genes (eg, CDH1 and VIM). To further define the genome‐wide location of H3K4Ac, a chromatin immunoprecipitation followed by massively parallel DNA sequencing (ChIP‐seq) analysis was performed using a head and neck squamous cell carcinoma (HNSCC) FaDu cell line under normoxia and hypoxia. H3K4Ac was found to be located mainly around the transcription start site. Coupled with analysis of gene expression by RNA sequencing and using a HDAC3 knockdown cell line, 10 new genes (BMI1, GLI1, SMO, FOXF1, SIRT2, etc) that were labeled by H3K4Ac and regulated by HDAC3 were identified. Overexpression or knockdown of GLI1/SMO increased or repressed the in vitro migration and invasion activity in OECM‐1/FaDu cells, respectively. In HNSCC patients, coexpression of GLI1 and SMO in primary tumors correlated with metastasis. Our results identify new EMT marker genes that may play a significant role in hypoxia‐induced EMT and metastasis and further provide diagnostic and prognostic implications.
Petrogenesis and geodynamic implications of Early Palaeozoic granitic rocks at the Hongshi Cu deposit in East Tianshan Orogenic Belt, NW China: Constraints from zircon U–Pb geochronology, geochemistry, and Sr–Nd–Hf isotopes
Authors: Cheng Xihui , Yang Fuquan , Zhang Rui , Xu Qiangfen , Yang Chengdong 
Published: August 2019

The Early Palaeozoic granitoid rocks represent a volumetrical component of the eastern part of the Dananhu–Tousuquan island arc belt of the East Tianshan and preserve useful information about the tectonomagmatic history of this region. The Hongshi intrusion primarily consists of granodiorite, which intrudes the Ordovician–Silurian Daliugou Formation in the Kalatag area. Zircon U–Pb dating of magmatic zircons from the granodiorite was formed at 426.6 ± 2.3 Ma, suggesting that the intrusion was emplaced in the Middle Silurian. Geochemically, granodiorite belongs to the metaluminous calc‐alkaline I‐type granitoids associated with a narrow range of SiO2 concentration (63.53–67.71 wt.%), A/CNK values ranging from 1.01 to 1.12. They have high Ba, LREE, and LILE contents and low abundance of HREE and HFSE. These samples displayed MgO contents of 1.38–1.52 wt.%, resulting in low K2O/Na2O ratios of 0.11–0.33 and intermediate Mg# values of 29.03–37.31, with high Sr/Y, La/Yb, and Ba/Th ratios, positive εNd(t) (6.60 to 7.95) and εHf(t) (13.1–16.0), low (87Sr/86Sr)i (0.704113–0.704312), and low Nb/U and Ta/U ratios. These features indicated that the parental magma of the granodiorite was probably derived from a juvenile crust with no significant mantle component involvement. Based on the regional geology and geochemical evidence, the Hongshi granodiorite is considered to have formed in an arc setting, associated with the northward subduction of the young Kangguer Ocean slab beneath the Dananhu island arc.
microRNA‐132 is overexpressed in glia in temporal lobe epilepsy and reduces the expression of pro‐epileptogenic factors in human cultured astrocytes
Authors: Korotkov Anatoly , Broekaart Diede W. M. , Banchaewa Leyla , Pustjens Ben , van Scheppingen Jackelien , Anink Jasper J. , Baayen Johannes C. , Idema Sander , Gorter Jan A. , van Vliet Erwin A. , Aronica Eleonora 
Published: August 2019

AbstractTemporal lobe epilepsy (TLE) is a chronic neurological disease in humans, which is refractory to pharmacological treatment in about 30% of the patients. Reactive glial cells are thought to play a major role during the development of epilepsy (epileptogenesis) via regulation of brain inflammation and remodeling of the extracellular matrix (ECM). These processes can be regulated by microRNAs (miRs), a class of small non‐coding RNAs, which can control entire gene networks at a post‐transcriptional level. The expression of miRs is known to change dynamically during epileptogenesis. miR‐132 is one of the most commonly upregulated miRs in animal TLE models with important roles shown in neurons. However, the possible role of miR‐132 in glia remains largely unknown. The aim of this study was to characterize the cell‐type specific expression of miR‐132 in the hippocampus of patients with TLE and during epileptogenesis in a rat TLE model. Furthermore, the potential role of miR‐132 was investigated by transfection of human primary cultured astrocytes that were stimulated with the cytokines IL‐1β or TGF‐β1. We showed an increased expression of miR‐132 in the human and rat epileptogenic hippocampus, particularly in glial cells. Transfection of miR‐132 in human primary astrocytes reduced the expression of pro‐epileptogenic COX‐2, IL‐1β, TGF‐β2, CCL2, and MMP3. This suggests that miR‐132, particularly in astrocytes, represents a potential therapeutic target that warrants further in vivo investigation.
Positive survival trend in metastatic head and neck cutaneous squamous cell carcinoma over four‐decades: Multicenter study
Authors: Hasmat Shaheen , Ebrahimi Ardalan , Luk Peter P. , Low Tsu‐Hui (Hubert) , McDowell Lachlan , Magarey Matthew J. R. , Veness Michael , Gupta Ruta , Clark Jonathan 
Published: August 2019

AbstractBackgroundThis study assessed changes over time of survival of head and neck cutaneous squamous cell carcinoma (HNcSCC) with lymph node metastases.MethodsA multicenter analysis of 1301 patients with metastatic HNcSCC treated between 1980 and 2017. Differences in disease‐specific survival (DSS) and overall survival (OS) by decade were assessed using multivariate Cox regression.ResultsOver the study period, we noted an increase in the proportion of patients aged over 80 years (3.9%‐31.7%; P < .001) and immunosuppression (1.9%‐9.9%; P = .03). After adjusting for number and size of metastatic nodes, extranodal extension, perineural invasion, immunosuppression, treatment, and institution, there was a reduction in risk of cancer‐related mortality from 0.47 in 1990‐1999 (P = .04) to 0.30 in 2000‐2009 (P < .001) when compared to 1980‐1989. This remained stable at 0.30 in 2010‐2017 (P = .001). OS remained stable after 1990.ConclusionDespite an aging and more frequently immunosuppressed population, fewer patients are dying from metastatic HNcSCC.
Treatment for lymphoma and late cardiovascular disease risk: A systematic review and meta‐analysis
Authors: Stone Chelsea R. , Mickle Alexis T. , Boyne Devon J. , Mohamed Aliya , Rabi Doreen M. , Brenner Darren R. , Friedenreich Christine M. 
Published: August 2019

AbstractBackground and aimsLymphoma patients are frequently treated with cancer therapies that may increase the risk of adverse health outcomes later in life, including cardiovascular disease (CVD) mortality. We sought to investigate the long‐term risk of CVD incidence in this survivor population relative to the general population to quantify this health burden.MethodsA systematic review and meta‐analysis was conducted using EMBASE, MEDLINE, and CINAHL databases, from date of inception to November 2016, with additional searches completed through June 2018. Included reports were observational studies assessing CVD incidence in patients of either Hodgkin or non‐Hodgkin lymphoma (HL, NHL) who survived for at least 5 years from the time of diagnosis or if the study had a median follow‐up of 10 years. Meta‐analyses were performed using random effects models, and subgroup analyses were conducted to determine the incidence of specific CVD subtypes (coronary heart disease, pericardial disease, valvular heart disease, myocardial disease, cardiac dysrhythmia, and cerebrovascular disease). Heterogeneity was assessed using I2 statistics and prediction intervals.ResultsOf the 7734 studies identified, 22 studies were included in this review, representing 32 438 HL and NHL survivors. Relative to the general population, lymphoma survivors had statistically significant two to threefold increases in the risk for nearly all subtypes of CVD examined. Lymphoma survivors appeared to be particularly susceptible to pericardial diseases (HL: 10.67, 95% confidence interval (CI), 7.75‐14.69; NHL: 4.70, 95% CI, 2.08‐10.61) and valvular diseases (HL: 13.10, 95% CI, 7.41‐23.16; NHL: 3.76, 95% CI, 2.12‐6.66). Although the 95% CIs were suggestive of increased risks, the 95% prediction intervals often included the null, reflecting the high heterogeneity of the estimates.ConclusionGiven the suggested increased risks of cardiovascular outcomes in lymphoma survivor populations relative to the general population, tailored screening and prevention programmes may be warranted to offset the future burden of disease.
Linking soil water balance with flood spatial arrangement in an extremely flat landscape
Authors: Vercelli Natalia , Varni Marcelo , Lara Bruno , Entraigas Ilda , Ares María Guadalupe 
Published: August 2019

AbstractIn areas with very mild relief, water drains in a disordered way due to the lack of a developed drainage network, as it occurs in extremely flat sedimentary regions like the Argentine Pampas. The study analysed the flood spatial arrangements in 2014 by calculating landscape metrics and relating them to soil water balance. The study area is located at Del Azul creek lower basin (Pampa Ecoregion, Argentina). Daily soil water balances were obtained, and seven landscape metrics were calculated in 15 windows in five LandSat images, all along 2014, to explore the relationship between hydrological scenarios and spatial pattern summarized with principal component analysis. Water excess concentrated in winter (June and August); deficits were in late spring and summer (January and November), whereas the beginning of autumn (March) was an intermediate situation. Principal component 1 (44.7%) reflected area and shape metrics and correlated positively with water table level; principal component 2 (32.3%) summarized aggregation ones and was negatively associated with accumulated water excesses or deficits in previous 30 days and useful reserve. Both exhibited possible threshold‐driven behaviour. Internal heterogeneity between NW and SE zones within the study area coincided with the existence of ancient alluvial fans. The results highlight the peculiarities of the flood spatial patterns in regions with very mild relief, where landforms usually determine water flows.
Silencing of lncRNA SNHG20 delays the progression of nonalcoholic fatty liver disease to hepatocellular carcinoma via regulating liver Kupffer cells polarization
Authors: Wang Bin , Li Xiangpan , Hu Wenjuan , Zhou Yu , Din Youming 
Published: August 2019

AbstractThis study aims to investigate the role of long noncoding RNA SNHG20 in the progression of nonalcoholic fatty liver disease (NALFD) to hepatocellular carcinoma (HCC), and to elucidate whether polarization of Kupffer cells (KCs, liver macrophages) was involved in this process. Mouse NALFD was induced by 16 weeks of high‐fat diet (HFD) feeding. Mouse NALFD‐HCC was induced by 36 weeks of HFD feeding (from 1 week to 36 weeks) and 20 weeks of diethyl nitrosamine (DEN) administration (from 17 weeks to 36 weeks). The LV‐shRNA‐ and LV‐sh‐SNHG20‐infected RAW264.7 cells were injected into the NALFD mice followed by DEN treatment to evaluate the role of SNHG20 in regulating the progression of NALFD to HCC in mice. The proportion of M1 and M2 macrophages was determined by flow cytometry. The levels of M1‐related inducible nitric oxide synthase (iNOS) and tumor necrosis factor‐α and M2‐related Arg‐1 and interleukin (IL)‐10 were also examined. SNHG20 expression was decreased in NALFD but increased in NALFD‐HCC, both in human and experimental mouse livers. Furthermore, human and mouse NALFD‐HCC KCs displayed decreased M1/M2 ratio compared with NALFD KCs. Moreover, SNHG20 overexpression induced M2 polarization through activating STAT6, whereas SNHG20 silencing suppressed M1 polarization in RAW264.7 macrophages and delayed the progression of NALFD to HCC in mice. SNHG20 may facilitate the progression of NALFD to HCC via inducing liver KCs M2 polarization via STAT6 activation.