bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of Langmuir Turbulence on the Thermal Response of the Ocean Surface Mixed Layer to Supertyphoon Haitang (2005)
Authors: Zhang Xuefeng , Chu Peter C. , Li Wei , Liu Chang , Zhang Lianxin , Shao Caixia , Zhang Xiaoshuang , Chao Guofang , Zhao Yuxin 
Published: June 2018

AbstractLangmuir turbulence (LT) due to the Craik–Leibovich vortex force had a clear impact on the thermal response of the ocean mixed layer to Supertyphoon Haitang (2005) east of the Luzon Strait. This impact is investigated using a 3D wave–current coupled framework consisting of the Princeton Ocean Model with the generalized coordinate system (POMgcs) and the Simulating Waves Nearshore (SWAN) wave model. The Coriolis–Stokes forcing (CSF), the Craik–Leibovich vortex forcing (CLVF), and the second-moment closure model of LT developed by Harcourt are introduced into the circulation model. The coupled system is able to reproduce the upper-ocean temperature and surface mixed layer depth reasonably well during the forced stage of the supertyphoon. The typhoon-induced “cold suction” and “heat pump” processes are significantly affected by LT. Local LT mixing strengthened the sea surface cooling by more than 0.5°C in most typhoon-affected regions. Besides LT, Lagrangian advection of temperature also modulates the SST cooling, inducing a negative (positive) SST difference in the vicinity of the typhoon center (outside of the cooling region). In addition, CLVF has the same order of magnitude as the horizontal advection in the typhoon-induced strong-vorticity region. While the geostrophy is broken down during the forced stage of Haitang, CLVF can help establish and maintain typhoon-induced quasigeostrophy during and after the typhoon. Finally, the effect of LT on the countergradient turbulent flux under the supertyphoon is discussed.
Frozen Section as a Rapid and Accurate Method for Diagnosing Acute Invasive Fungal Rhinosinusitis
Authors: Hennessy Max , McGinn Johnathan , White Bartholomew , Payne Sakeena , Warrick Joshua I. , Crist Henry 
Published: June 2018

ObjectiveIdentify methods to improve the frozen‐section diagnosis of acute invasive fungal rhinosinusitis.Study DesignBiopsies with frozen section for suspected acute invasive fungal rhinosinusitis were reviewed to identify causes for missed diagnoses and evaluate methods for potential improvement.SettingAll aspects of the study were performed at the Penn State Milton S. Hershey Medical Center.Subjects and MethodsAll frozen sections performed for suspected acute invasive fungal rhinosinusitis between 2006 through 2017 were reviewed with their diagnoses compared to the final diagnoses. Sensitivity and specificity were determined for each biopsy specimen to evaluate the diagnostic method and for each patient for its effectiveness on outcome. Causes for frozen‐section failures in diagnosis were identified. A periodic acid–Schiff stain for fungus (PASF) was modified for use on frozen tissue (PASF‐fs) and applied both retrospectively and prospectively to frozen sections to determine its ability to identify undetected fungus and improve diagnostic sensitivity.ResultsOf 63 biopsies positive for acute invasive fungal rhinosinusitis, 51 were diagnosed on frozen section, while 61 were identified by including the novel PASF‐fs stain, reducing the failure rate from 19% to 3%. Of 41 cases that were positive, 34 were diagnosed on frozen section. Of the 7 that were not, 5 were identified by including the PASF‐fs, reducing the failure rate from 17% to 5%.ConclusionsFrozen section interpretation of biopsies for suspected acute invasive fungal rhinosinusitis using a PASF‐fs stain should enable a rapid and accurate diagnosis with improved outcomes by shortening the time to surgery.
Swallowing outcomes in patients with subcortical stroke associated with lesions of the caudate nucleus and insula
Authors: Im Ikjae , Jun Je-Pyo , Hwang Seungbae , Ko Myoung-Hwan 
Published: June 2018

Objective The present study was performed to investigate the relationships between swallowing outcomes and lesion location, bolus characteristics, and age in patients with subcortical stroke. Patients: Patients with subcortical and insular stroke (mean age, 57.38 ± 12.71 years) were investigated. All patients (n = 21) completed both brain magnetic resonance imaging studies and videofluoroscopic swallowing studies. Main Outcome Measures The oral transit duration, pharyngeal transit duration (PTD), laryngeal response duration, and Penetration-Aspiration Scale (PAS) score were applied to examine the efficiency of propulsion and airway protection in three swallowing tasks. Path analyses were performed to assess the relationships between swallowing outcomes and lesion location, age, bolus viscosity, and bolus volume. Results Caudate nucleus (CN) lesions were associated with higher PAS scores. Insular lesions were associated with a longer PTD. Advanced age was associated with a longer PTD. Bolus viscosity significantly moderated the association between CN lesions and higher PAS scores. Conclusions In the present cohort, CN lesions impacted airway protection and insular lesions impacted pharyngeal transit. An increased bolus viscosity reduced the aspiration severity. These results suggest that lesion location is an important indicator to predict subsequent dysphagia in patients with subcortical stroke.
Impact and Feasibility of Implementing a Systematic Approach for Medication Therapy Management in the Community Pharmacy Setting: A Pilot Study
Authors: Murray Marie E. , Barner Jamie C. , Pope Nathan D. , Comfort Mark D. 
Published: June 2018

Objective: To determine how implementing a systematic medication therapy management (MTM) process impacted MTM completion rates. Methods: This process improvement pilot included 4 grocery store-based community pharmacy sites. Site staff were trained on a systematic process to integrate OutcomesMTM opportunities into pharmacy workflow. Technicians prepared MTM paperwork, including a standardized comprehensive medication review (CMR) worksheet, which pharmacists used to deliver the service at the counsel window. The primary outcome was the change in CMR completion rate from pre- to post implementation, with each site serving as its own control. Secondary outcomes were change in targeted intervention program (TIP) completion rate and survey results assessing barriers and feasibility. Results: The mean CMR completion rate improved from 2.7% ± 5.4% to 23.2% ± 7.7% ( P < .10). The mean TIP completion rate improved from 3.4% ± 4.2% to 24.9% ± 19.2% ( P < 0.10) pre- to post-implementation. Survey results indicated that pharmacists were satisfied with this; the most significant barriers were time spent contacting prescribers, documentation, and claim submission. Conclusion: Implementing this systematic approach to providing MTM into the pharmacy workflow may lead to an improvement in CMR completion rate. However, the sample size is small, and the results and process may not be generalizable to other sites.
Revision surgery for leg length inequality after primary hip replacement
Authors: McWilliams Anthony B , Lampropoulos Anastasios , Stone Martin H 
Published: June 2018

Background: We discuss the surgical results of revision surgery for patients with refractory symptomatic leg length inequality (LLI) after primary hip replacement. Methods: This is a retrospective review of 21 patients who underwent revision for LLI after primary total hip replacement. All of them were referred to a tertiary clinic between 2006 and 2015. Leg length was measured, to the nearest mm, using Woolson’s validated X-ray technique which references to centre of femoral rotation, the acetabular teardrop and the midpoint of the lesser trochanter. The post-operative clinical assessment using a modified D’Aubigne and Postel scoring system investigated the pain, function, and satisfaction after surgery. Results: The mean pre-revision LLI was 16.2 mm (8–30 mm). The mean post revision operation leg length inequality was 2.0 mm (12 mm short to 9 mm long). The mean post-operative D’Aubigne and Postel scores, achieved at a mean 12 months (6–30 months), were; pain 5.2 (3–6), function 4.6 (3–6) and satisfaction 4.4 (3–5). Following revision surgery 20 out of 21 (95%) patients were satisfied with the improvement in LLI. Conclusion: Revision surgery for LLI, while it may not resolve all of the pain that the patient presents with, it is a successful treatment for patients who do not respond to conservative management of their LLI.
Aspirin versus placebo in pregnancies at high risk for preterm pre-eclampsia
Authors: Story Lisa , Nelson-Piercy Catherine 
Published: June 2018

A recent multicentre placebo-controlled trial by Rolnick et al. has indicated that taking 150 mg aspirin daily in women at high risk of pre-eclampsia reduced the incidence of the disease from 4.3% to 1.5% in comparison with placebo. Although the findings of this study are important, a high proportion of women withdrew their consent and not all safety outcomes have been reported. This journal watch article discusses the paper in more detail.
Local Atopy in Childhood Adenotonsillar Hypertrophy
Authors: Cho Kyu-Sup , Kim Seong Heon , Hong Sung-Lyong , Lee Jaeyoung , Mun Sue Jean , Roh Young Eun , Kim Young Mi , Kim Hye-Young 
Published: June 2018

Background Although the cause of adenotonsillar hypertrophy remains unknown, some studies have shown that allergy may be a risk factor. Purpose This study determined the levels of allergen-specific immunoglobulin E (sIgE) in the adenotonsillar tissues of children with adenotonsillar hypertrophy and evaluated the clinical significance of local atopy in adenotonsillar tissues. Methods We measured 21 types of specific immunoglobulin E in the serum and adenotonsillar tissues of 102 children with adenotonsillar hypertrophy and compared the sensitization patterns of the serum and local tissues. The patients were divided into three groups—atopy, local atopy, and nonatopy—according to the sensitization of serum and adenotonsillar tissues, and the clinical symptoms among the groups were analyzed. Results Seventy-two (70.6%) children with adenotonsillar hypertrophy were sensitized to more than one allergen in the serum and/or adenotonsillar tissue. Thirty (29.4%) children had no IgE positivity to any allergen in both serum and adenotonsillar tissues. Fifty-five (53.9%) were sensitized to at least one allergen in the serum. Seventy (68.6%) were sensitized to at least one allergen in the adenotonsillar tissue. Seventeen (36.2%) of 47 children with specific immunoglobulin E-negative serum had specific immunoglobulin E-positive adenotonsillar tissues. The rate of specific immunoglobulin E was significantly higher in local tissues than in serum. The rate of inhalant allergen specific immunoglobulin E was significantly higher in the adenoids than in the tonsils. However, the rate of food allergen specific immunoglobulin E was significantly higher in the tonsils than adenoids. The lifetime prevalence of asthma and allergic rhinitis, recent symptoms or treatment of allergic rhinitis, and severity of nasal symptoms (rhinorrhea, sneezing, and nasal itching) were significantly higher in children with local atopy than with nonatopy. Conclusions These results confirm that allergic response may be a risk factor for adenotonsillar hypertrophy. Local allergic inflammation may play an important role in childhood adenotonsillar hypertrophy, and local atopy in adenotonsillar tissues can cause respiratory allergic symptoms in children.
Transnasal Endoscopic Sphenopalatine Artery Ligation Compared With Embolization for Intractable Epistaxis: A Long-term Analysis
Authors: de Bonnecaze G. , Gallois Y. , Bonneville F. , Vergez S. , Chaput B. , Serrano E. 
Published: June 2018

Background Transnasal endoscopic sphenopalatine artery ligation (TESPAL) and selective embolization both provide excellent treatment success rate in the management of intractable epistaxis. Few long-term studies comparing these approaches have been previously published. Recommendations often present these techniques as alternatives, but there is no clear consensus. Objective The purpose of this study was to evaluate and compare the clinical efficacy of sphenopalatine artery ligation versus embolization to control intractable epistaxis. Methods We performed a retrospective study including all patients referred to our tertiary medical center for severe epistaxis and treated by surgical ligation and/or embolization. The patients were classified into 2 groups: those who underwent TESPAL only and those who underwent endovascular embolization only. We evaluate and compare long-term clinical outcomes after surgical ligation or embolization for the control of intractable epistaxis in terms of effectiveness (recurrence rate) and safety (complication rate). Results Forty-one procedures of supraselective embolization and 39 procedures of surgical ligation for intractable epistaxis are reported and analyzed. No significant difference was observed between the groups in terms of demographic factors, comorbidities, or average length of hospital stay. The 1-year success rate was similar (75%) in both groups. Complications (minor and/or major) occurred in 34% cases in the embolization group and in 18% in the surgical group ( P = .09, ns). Bilateral embolization including facial artery was the only treatment method associated with a significant risk of complications ( P = .015). Conclusion TESPAL seems to provide a similar control rate with a decrease in the number of complications compared to selective embolization in the context of intractable epistaxis. Further studies are required.
Laparoscopic sacrocolpopexy is as safe in septuagenarians or elder as in younger women
Authors: Vossaert Karlien , Housmans Susanne , Pacquée Stefaan , Callewaert Geertje , Cattani Laura , Van der Aa Frank , Wolthuis Albert , D’hoore André , Roelandt Philip , Deprest Jan 
Published: June 2018

Abstract
Background
Data concerning laparoscopic sacrocolpopexy (LSCP) in elder women are scarce. We compared intra-operative and early-postoperative complications associated with laparoscopic colpo-, cervico-, or hysteropexy in women under and above 70 years.

Methods
Retrospective assessment by an independent investigator of a prospective cohort of 571 consecutive women undergoing LSCP in a tertiary unit over an 18-year period. Data included were patient demographics, operative variables, intra-operative, and early (≤ 3 months) postoperative complications. Complications were graded according to the Clavien-Dindo classification and mesh complications categorized using the International Urogynaecological Association (IUGA)-classification.

Findings
Median age was 66 (IQR 15, range 27-91) and 204 (35.7%) patients were older than 70 years. There were no deaths. Strategic conversion rate was 2.3% (13/571), the majority because of extensive adhesions yet early in our experience. Reactive conversion rate was 0.7% (4/571). Among 554 patients who had a completed LSCP, there were 20 intra-operative complications (3.6%), mostly bladder (1.3%) and vaginal (1.1%) injuries. Eighty-four patients had a total of 95 early-postoperative Dindo ≥ II complications (15.1%). Most common complications were infectious and treated medically (Dindo II). Clinically major complications are rare (III = 3.1% and IV = 0.2%). Reoperation for suspected bleeding (IIIb = 0.7%) was the most common reintervention, typically without demonstrable cause. Most mesh complications were vaginal exposures. Septuagenarians were not more likely to have an intra-operative (4.0 vs 3.3% < 70 years, p = 0.686) or early-postoperative complication (13.6 vs 16.0% < 70 years, p = 0.455) than younger patients. Mesh complications were also equally uncommon.

Conclusions
LSCP is as well-tolerated by women above 70 years as by younger women.
UK podiatrists' experiences of podiatry services for people living with arthritis: a qualitative investigation
Authors: McCulloch Louise , Borthwick Alan , Redmond Anthony , Edwards Katherine , Pinedo‐Villanueva Rafael , Prieto‐Alhambra Daniel , Judge Andrew , Arden Nigel K. , Bowen Catherine J. 
Published: June 2018

AbstractBackgroundProvision of podiatry services, like other therapies in the UK, is an area that lacks guidance by the National Institute for Health and Care Excellence. Many individuals living with arthritis in the UK are not eligible to access NHS podiatry services. The primary aim of this investigation was to understand the views of podiatry clinicians on their experiences of referral, access, provision and treatment for foot problems for patients who have arthritis.MethodsFocus groups were undertaken to explore, in‐depth, individual views of podiatrists working in the UK to gain feedback on experiences of barriers and facilitators to referral, access, provision and treatment for foot problems for individuals living with arthritis. A purposive sampling strategy was adopted and two, semi‐structured, focus group interviews conducted, involving 12 podiatrists from both NHS and independent sectors. To account for geographical variations one focus group took place in each of 2 predetermined ‘zones' of the UK; Yorkshire and Hampshire. Thematic analysis was employed to identify key meanings and report patterns within the data.ResultsThe key themes derived from the podiatry clinician focus groups suggest a variety of factors influencing demand for, and burden of, foot pain within the UK. Participants expressed frustration on having a service that accepts and treats patients according to their condition, rather than their complaint. Additionally, concern was conveyed over variations in the understanding of stakeholders' views of what podiatry is and what podiatrists aim to achieve for patients.ConclusionPodiatrists interviewed believed that many individuals living with arthritis in the UK are not eligible to access NHS podiatry services and that this may be, in part, due to confusion over what is known about podiatry and access criteria. Essentially, podiatrists interviewed called for a timely renaissance of current systems, to newer models of care that meet the foot care needs of individual patients' circumstances and incorporate national multi‐disciplinary guidance. Through this project, we have formulated key recommendations that are directed towards improving what other stakeholders (including GPs, commissioners and users of podiatry services) know about the effectiveness of podiatry and also to futureproof the profession of podiatry.
Physiological evaluation of the behavior and epidermis of freshwater planarians (Girardia tigrina and Girardia sp.) exposed to stressors
Authors: de Oliveira Matheus Salgado , Lopes Karla Andressa Ruiz , Leite Priscila Maria Sarmeiro Corrêa Marciano , Morais Flavia Villaça , de Campos Velho Nádia Maria Rodrigues 
Published: June 2018

ABSTRACT
Planarians are metazoan freshwater flatworms which are free-living organisms. Their body has pluripotent stem cell promoters of tissue regeneration capacity. The water temperature and the potential of hydrogen (pH) of lentic ecosystems are important factors involved in the distribution and abundance of these animals. Although the pH factor is directly related to the physiology and behavior of planarians, their adaptive and regenerating capacities still remain unknown. The Critical Thermal Maximum (CTM) is a very widespread method used in the evaluation of thermal tolerance. In this study, Girardia tigrina (Girard, 1850) and Girardia sp., a species found in Brazil, which is under study as a new species, had their epidermis assessed by scanning electron microscopy (SEM) to analyze their physiological structures before and after exposure to different stressors. SEM was used as a method to evaluate the planarians' epidermis as a result of the increasing temperature (CTM) and pH alterations, the latter with the use of a new methodology defined as Critical Hydrogen ion concentration Maximum (CHM). In increasing temperatures from 20°C to 37°C, both Girardia tigrina and Girardia sp. proved to be adaptable to thermal stress. Girardia sp. was shown to be more resistant to higher temperatures. However, Girardia tigrina was more resistant to extreme pH conditions (4.0 to 10.0). SEM analysis showed morphological differences among planarian species, such as the arrangement of the structures and cell types of the dorsal epidermis. Moreover, planarians demonstrated the ability to change the surrounding pH of their external environment in order to maintain the function of their physiological mechanisms, suggesting that these animals have a complex survival system, possibly related to protonephridia, flame cells and excretory pores.
This article has an associated First Person interview with the first author of the paper.
Nuclear genes, matK and the phylogeny of the Poales
Authors: Hochbach Anne , Linder H. Peter , Röser Martin 
Published: June 2018

AbstractPhylogenetic relationships within the monocot order Poales have been well studied, but several unrelated questions remain. These include the relationships among the basal families in the order, family delimitations within the restiid clade, and the search for nuclear single­copy gene loci to test the relationships based on chloroplast loci. To this end two nuclear loci (PhyB, Topo6) were explored both at the ordinal level, and within the Bromeliaceae and the restiid clade. First, a plastid reference tree was inferred based on matK, using 140 taxa covering all APG IV families of Poales, and analyzed using parsimony, maximum likelihood and Bayesian methods. The trees inferred from matK closely approach the published phylogeny based on whole­plastome sequencing. Of the two nuclear loci, Topo6 supported a congruent, but much less resolved phylogeny. By contrast, PhyB indicated different phylogenetic relationships, with, inter alia, Mayacaceae and Typhaceae sister to Poaceae, and Flagellariaceae in a basally branching position within the Poales. Within the restiid clade the differences between the three markers appear less serious. The Anarthria clade is first diverging in all analyses, followed by Restionoideae, Sporadanthoideae, Centrolepidoideae and Leptocarpoideae in the matK and Topo6 data, but in the PhyB data Centrolepidoideae diverges next, followed by a paraphyletic Restionoideae with a clade consisting of the monophyletic Sporadanthoideae and Leptocarpoideae nested within them. The Bromeliaceae phylogeny obtained from Topo6 is insufficiently sampled to make reliable statements, but indicates a good starting point for further investigations. We find that matK is remarkably good at retrieving the chloroplast phylogeny, that Topo6, despite low resolution, is suitable to test the generality of the plastid phylogeny as a taxic phylogeny, that PhyB might be too complex to be really useful at the level of families within an order, that the inclusion of the centrolepids in Restionaceae might be valid, but that there is no phylogenetic support for or against including the Anarthria clade in Restionaceae. The basal arrangement of families in the Poales (Bromeliaceae, Typhaceae, Rapateaceae) remains unresolved.