bluuebunny/crossref_metadata_2025_split huggingface dataset:
Imprinted maternally-expressed microRNAs antagonize paternally-driven gene programs in neurons
Authors: Whipple Amanda J. , Jacobs Hannah N. , Breton-Provencher Vincent , Sur Mriganka , Sharp Phillip A. 
Published: July 2019

SummaryImprinted genes with parental-biased expression are hypothesized to result from an evolutionary conflict between the parental genomes over procurement of maternal resources. Accordingly, imprinted genes are enriched in pathways regulating nutrient acquisition, energy homeostasis, and growth. Here, we functionally characterize a large cluster of maternally-expressed microRNAs (miRNAs) to explore why they evolved imprinted expression in neurons. Using an induced neuron (iN) culture system, we show maternally-expressed miRNAs from the miR-379/410 cluster repress paternally-expressed genes, including known regulators of energy homeostasisPlagl1andPeg3. Additional non-imprinted metabolic regulators are also co-targeted by miR-379/410. Maternal deletion of this imprinted miRNA cluster results in de-repression of its targets and up-regulation of a broader gene program regulating feeding behavior and synaptic transmission. These data suggest non-coding RNAs actively engage in parental genomic conflict, whereby maternally-expressed miRNAs antagonize paternally-driven gene programs in neurons.
Reshaping theHexagone: the genetic landscape of modern France
Authors: Biagini Simone Andrea , Ramos-Luis Eva , Comas David , Calafell Francesc 
Published: July 2019

AbstractUnlike other European countries, the human population genetics and demographic history of Metropolitan France is surprisingly understudied. In this work, we combined newly genotyped samples from various zones in France with publicly available data and applied both allele frequency and haplotype-based methods in order to describe the internal structure of this country, by using genome-wide single nucleotide polymorphism (SNP) array genotypes. We found out that French Basques are genetically distinct from all other populations in theHexagoneand that the populations from southwest France (namely the Gascony region) share a large proportion of their ancestry with Basques. Otherwise, the genetic makeup of the French population is relatively homogeneous and mostly related to Southern and Central European groups. However, a fine-grained, haplotype-based analysis revealed that Bretons slightly separated from the rest of the groups, due mostly to gene flow from the British Isles in a time frame that coincides both historically attested Celtic population movements to this area between the 3th and the 9th centuries CE, but also with a more ancient genetic continuity between Brittany and the British Isles related to the shared drift with hunter-gatherer populations. Haplotype-based methods also unveiled subtle internal structures and connections with the surrounding modern populations, particularly in the periphery of theHexagone.
An overview of data-driven HADDOCK strategies in CAPRI rounds 38-45
Authors: Koukos P.I. , Roel-Touris J. , Ambrosetti F. , Geng C. , Schaarschmidt J. , Trellet M.E. , Melquiond A.S.J. , Xue L.C. , Honorato R.V. , Moreira I. , Kurkcuoglu Z. , Vangone A. , Bonvin A.M.J.J. 
Published: July 2019

ABSTRACTOur information-driven docking approach HADDOCK has demonstrated a sustained performance since the start of its participation to CAPRI. This is due, in part, to its ability to integrate data into the modelling process, and to the robustness of its scoring function. We participated in CAPRI both as server and as manual predictors.In CAPRI rounds 38-45, we have used various strategies depending on the information at hand. These ranged from imposing restraints to a few residues identified from literature as being important for the interaction, to binding pockets identified from homologous complexes or template-based refinement / CA-CA restraint-guided docking from identified templates. When relevant, symmetry restraints were used to limit the conformational sampling. We also tested for a large decamer target a new implementation of the MARTINI coarse-grained force field in HADDOCK. Overall in the current rounds, we obtained acceptable or better predictions for 13 and 11 server and manual submissions, respectively, out of the 22 interfaces. Our server performance (acceptable models) was better (59%) than the manual (50%) one, in which we typically experiment with various combinations of protocols and data sources. Again, our simple scoring function based on a linear combination of intermolecular van der Waals and electrostatic energies and an empirical desolvation term demonstrated a good performance in the scoring experiment with a 63% success rate across all 22 interfaces.An analysis of model quality indicates that, while we are consistently performing well in generating acceptable models, there is room for improvement for generating/identifying higher quality models.
The role of specialist inpatient rehabilitation services for people with intellectual disability, autism and mental health, behavioural or forensic needs
Authors: Odiyoor Mahesh , Tromans Samuel Joseph , Alexander Regi T. , Akbari Srinaveen , Bell Gill , Bering Sandy , Jaydeokar Sujeet , Shetty Amrith 
Published: July 2019

Purpose
The purpose of this paper is to provide a professional consensus position with regard to the provision of specialist inpatient rehabilitation services for people with intellectual disability (ID), autism and mental health, behavioural or forensic needs in the UK.

Design/methodology/approach
The concept of rehabilitation is discussed, as well as the functions and goals of specialist inpatient rehabilitation services with regard to the aforementioned contexts. Current use of rehabilitation beds is considered, both on a regional and national scale, as well as various outcome measures, including effectiveness, patient safety and patient experience.

Findings
There is a clear need for specialist inpatient rehabilitation services, though historically there have been instances of inappropriate admissions, as well as lengthy inpatient stays that could have been significantly reduced with the right type of community support package. Such services should be subjected to rigorous measurement of outcome measures, to determine that patients within such services are receiving a consistently high standard of care. Additionally, amendments to current legal frameworks should be considered, with a view to accommodating for individuals with capacity who require continuous community-based supervision.

Originality/value
To the best of the author’s knowledge, this is the first article detailing a professional consensus position for specialist inpatient rehabilitation services for people with ID, autism and mental health, behavioural or forensic needs.
MNE as a catalyst for field-level institutional change in the Russian bakery sector
Authors: Pelto Elina , Karhu Anna 
Published: July 2019

PurposeThe purpose of this paper is to focus on analysing how foreign entry by a multinational enterprise (MNE) can act as a catalyst for change in field-level institutional logics in a transition economy context.Design/methodology/approachThe paper presents an empirical single-case study on the effects of an MNE’s entry on a particular industry in an emerging market’s context. The empirical study follows abductive reasoning; based on the interplay of previous literature and empirical observations, it identifies mechanism through which MNEs can catalyse change in field-level institutional logics.FindingsThe study shows that in addition to general market transition influenced by state-level policies, individual companies’ strategies, actions and market behaviour also significantly contribute to the development of a host industry’s field-level institutional logics. More precisely, a case study of a Finnish MNE’s entry into the Russian bakery market identifies the mechanisms and various change pathways through which the entry of a single MNE into a transition economy can significantly alter the institutional logics of a particular industry.Originality/valueThe study employs a novel perspective that incorporates the ideas, concepts and insights of an institutional logics perspective to MNE entry research for empirical analysis and theory building.
Conditions that mediate teacher agency during assessment reform
Authors: Willis Jill , McGraw Kelli , Graham Linda 
Published: July 2019

PurposeA new senior curriculum and assessment policy in Queensland, Australia, is changing the conditions for teaching and learning. The purpose of this study was to consider the personal, structural and cultural conditions that mediated the agency of Senior English teachers as they negotiated these changes. Agency is conceptualised as opportunities for choice in action arising from pedagogic negotiations with students within contexts where teachers’ decision-making is circumscribed by other pressures.Design/methodology/approachAn action inquiry project was conducted with English teachers and students in two secondary schools as they began to adjust their practices in readiness for changes to Queensland senior assessment. Four English teachers (two per school) designed a 10-week unit of work in Senior English with the aim of enhancing students’ critical and creative agency. Five action/reflection cycles occurred over six months with interviews conducted at each stage to trace how teachers were making decisions to prioritise student agency.FindingsParticipating teachers drew on a variety of structural, personal and cultural resources, including previous experiences, time to develop shared understandings and the responsiveness of students that mediated their teacher agency. Teachers’ ability to exert agentic influence beyond their own classroom was affected by the perceived flexibility of established resources and the availability of social support to share student success.Originality/valueThese findings indicate that a range of conditions affected the development of teacher agency when they sought to design assessment to prioritise student agency. The variety of enabling conditions that need to be considered when supporting teacher and student agency is an important contribution to theories of agency in schools, and studies of teacher policy enactment in systems moving away from localised control to more remote and centralised quality assurance processes.
MHD mixed convection boundary layer stagnation-point flow on a vertical surface with induced magnetic field
Authors: Md Ali Fadzilah , Naganthran Kohilavani , Nazar Roslinda , Pop Ioan 
Published: July 2019

Purpose
This study aims to perform a stability analysis on a steady magnetohydrodynamic (MHD) mixed convection boundary-layer stagnation-point flow of an incompressible, viscous and electrically conducting fluid over a vertical flat plate. The effect of induced magnetic field is also considered.

Design/methodology/approach
The governing boundary layer equations are transformed into a system of ordinary differential equations using the similarity transformations. The system is then solved numerically using the “bvp4c” function in MATLAB.

Findings
Dual solutions are found to exist for a certain range of the buoyancy parameter for both the assisting and opposing flows. The results from the stability analysis showed that the first solution (upper branch) is stable and valid physically, while the second solution (lower branch) is unstable.

Practical implications
This problem is important in many metallurgical processes, namely, drawing, annealing and tinning of copper wires. The results obtained are very useful for researchers to determine which solution is physically stable, whereby mathematically more than one solution exists for the skin friction coefficient and the heat transfer characteristics.

Originality/value
The present results of the stability analysis are original and new for the problem of MHD mixed convection stagnation-point flow of viscous conducting fluid over a vertical flat plate, with the effect of induced magnetic field.
Improved hydrodynamic performance of liquid film seal by considering boundary slip and cavitation
Authors: Wang Yun-Lei , Wu Jiu-Hui , Hao Mu-Ming , Xu Lu-Shuai 
Published: July 2019

Purpose
The purpose of this paper is to investigate the effect of boundary slip on hydrodynamic performance of liquid film seal considering cavitation.

Design/methodology/approach
A mathematical model of liquid film seal with slip surface was established based on the Navier slip model and Jakobsson–Floberg–Olsson (JFO) boundary condition. Liquid film governing equation was discretized by the finite difference method and solved by the SOR relaxation iterative algorithm and the hydrodynamic performance parameters of liquid film seal were obtained considering boundary slip and cavitation.

Findings
The results indicate that the values of performance parameters are affected significantly by the slip length under the condition of high speed and low differential pressure.

Originality/value
The performances of liquid film seal are investigated considering slip surface and cavitation. The results presented in the study are expected to provide a theoretical basis to improve the design method of liquid film seal.
Dynamic characteristics of elastic ring squeeze film damper
Authors: Wang Zhenlin , Liu Zhansheng , Zhang Guanghui 
Published: July 2019

Purpose
The purpose of this paper is to present a numerical model to investigate the dynamic behavior and force coefficients of a compact squeeze film damper with dual film clearances adjusted by an elastic ring, known as elastic ring squeeze film damper (ERSFD).

Design/methodology/approach
The governing equations of ERSFD as well as the boundary conditions are obtained based on Reynolds equation. A simplified Greenwood–Williamson model is implemented to investigate the contact behavior between the elastic ring and the journal. The interactions between the films and the elastic ring are achieved by block iterative method.

Findings
The radial deformation as well as velocity of the elastic ring are captured to illustrate the pressure profiles of the inner and outer films. High-order frequency components related to the number of the boss N are observed on the frequency spectrum of the film force. The force coefficients of the ERSFD are constant for a wider range of non-dimensional whirling radius ε compared with conventional squeeze film damper.

Originality/value
The force coefficients of the ERSFD are obtained by assuming that the journal center moves in a circular centered orbit. High-order frequency components related to the number of bosses N are observed. These findings may provide helpful materials for the application of the ERSFD.
Factors influencing research data communication on Zika virus: a grounded theory
Authors: da Costa Michelli Pereira , Lima Leite Fernando César 
Published: July 2019

Purpose
The purpose of this paper is to propose a theoretical model to illustrate factors influencing research data communication on diseases caused by the Zika virus.

Design/methodology/approach
The grounded theory methodology was adopted. For data collection, interviews were conducted with 13 Brazilian researchers involved with the Zika virus theme. Data analysis was performed using the open, axial and selective coding processes, according to the principles of the grounded theory.

Findings
Based on data collection and analysis, seven theoretical categories representing intervening factors in Zika virus research data communication were identified. The emerging theory showed the centrality of researchers’ expectations for acknowledgment and reward, influenced by the aspects of research funding and academic culture. Three factors involved in the macro processes of research data communication: data use, data production and data sharing. In the use and production processes, factors related to collaboration figured most strongly. In the production and sharing processes, the factors regarding data processing and the use of research data repositories were more pronounced. Finally, data sharing, and the possibility of reusing data are directly affected by the social context of Zika virus disease as an emerging disease.

Originality/value
The study presents a theory developed systematically to explain the phenomenon of communication of research data on Zika virus. The theory presents a set of intervening factors of the process of communication of research data and discusses the factors in light of the fundamentals of information science.
Considering production time in allocating costs and estimating profits at a Fortune 500 manufacturing corporation
Authors: Lelkes Anne-Marie T. , Krueger Thomas M. 
Published: July 2019

Purpose
Prior research has used computer-generated data to illustrate the benefits of the recently developed duration-based costing (DBC) and its affiliate modified duration-based costing (MDBC). The purpose of this paper is to use data from a Fortune 500 corporation to compare its traditional, or functional-based, cost allocation method with that of the recently developed DBC and MDBC models.

Design/methodology/approach
A Fortune 500 company provided one month of production data for a particular, key machine within its manufacturing process. The data were used to apply DBC and MDBC.

Findings
Variations arising from differences in the models’ cost allocation reveal the advantages of using time-based cost allocation over the traditional, mostly non-time-based allocation to estimate profit.

Research limitations/implications
By using actual data, this case study enhances prior theoretical research concerning the benefits of utilizing DBC and MDBC over the traditional costing method.

Practical implications
This case study is of benefit to practitioners who use traditional costing since it will encourage them to explore DBC and/or MDBC that tend to be more accurate in situations where the old adage of “time is money” applies. Implementing DBC and MDBC was not difficult to do for the Fortune 500 company as all of the components to run the models were readily available.

Originality/value
This is the first study to utilize actual company data to illustrate DBC and MDBC, and thus, adding to the literature concerning DBC and MDBC.
The tension between intention and attention
Authors: Doornich June Borge , Kaarbøe Katarina , Bourmistrov Anatoli 
Published: July 2019

Purpose
This paper aims to explore how changes in the coercive and enabling orientations of the organizational rule system influence the attention managers pay to rules.

Design/methodology/approach
The findings of a case study covering a multinational energy company, which are interpreted based on insights from the coercive/enabling bureaucracy literature and the evolution of rules literature, help explain how rules can direct attention.

Findings
The findings suggest that the tensions between corporate management’s intentions for an organization’s rule system and the attention middle (country) managers pay to those rules were the main driver of dialectic changes in the rule system. The more coercive the rule system became, the more middle managers diverted their attention away from rule compliance. The paper shows how the dialect change process constituted a dynamic interaction between mindful “rule setters” and mindful “rule followers.” The alignment between intentions and attention was reestablished by better balancing the coercive and enabling orientations of the rule system: enabling better flexibility, enhancing internal transparency based on local business logic and improving global transparency through closer alignment of local and global growth and efficiency goals. Surprisingly, the repair characteristic was not as important.

Originality/value
The findings contribute to the literature by showing how the enabling and coercive characteristics of an organizational rule system constitute managerial attention artifacts. The paper demonstrates how tensions between corporate intentions and local contingencies in the context of global organizations can lead to constrictive change and create a win-win situation for both central and local actors by better balancing the coercive and enabling orientations of the rule system. It also offers new insights into the dialectic change process in an organization’s rule system based on attention view toward organizational rules.
A critical assessment of retail sovereign sukuk in Indonesia
Authors: Sukmana Raditya 
Published: July 2019

Purpose
The purpose of this paper is to critically evaluate the retail sovereign sukuk in Indonesia, which so far is not found elsewhere in the world and is an effective instrument to raise funds for covering government budget deficits.

Design/methodology/approach
The paper adopts qualitative research combining literature studies, valid data from sukuk.com, government official documents and also in-depth interviews with relevant government officials to strengthen the arguments.

Findings
Competitive rates, ability to be bought by individual and risk-free funding are some of the specific features of sukuk, while economic growth and large populations are some of the key success factors.

Practical implications
This study will be the main reference for other governments which are keen to adopt similar instruments for their respective countries.

Social implications
As individual is eligible to buy this sukuk, this may lead to a better wealth distributions

Originality/value
To the best of the author’s knowledge, this paper is the first to comprehensively and critically evaluate the one and only retail sovereign sukuk as an alternative government instrument to raise funds.
J‐curve association between alcohol intake and varicose veins in Japan: The Shimane CoHRE Study
Authors: Kohno Kunie , Niihara Hiroyuki , Hamano Tsuyoshi , Takeda Miwako , Nakagawa Yusei , Shiwaku Kuninori , Nabika Toru , Zöller Bengt , Li Xinjun , Sundquist Kristina , Sundquist Jan , Morita Eishin 
Published: July 2019

AbstractThe effect of alcohol intake on varicose veins (VV) has not been determined by its consumption level. The aim of this study was to investigate the association between alcohol intake and VV in an elderly general population. Using a cross‐sectional approach, the Shimane CoHRE Study data, comprising a total of 1060 participants, were analyzed. By multivariate regression analysis adjusted with basic characteristics, past work history, lifestyle‐related factors and medical history, compared with non‐drinkers, mild drinkers (<20.0 g/day) showed a significantly lower adjusted odds ratio (aOR) of VV (aOR = 0.64, P = 0.036). In a similar way, regular drinkers (1–5 days/week) showed a significantly lower aOR of VV when compared with occasional drinkers (aOR = 0.57, P = 0.032). VV and alcohol intake showed J‐curve relationships. In a stratified analysis by alcohol consumption levels, the association of smoking and VV were also observed in moderate to heavy drinkers and habitual drinkers. These findings can provide better understanding of pathophysiological mechanism and be used for evidence‐based patient education.