bluuebunny/crossref_metadata_2025_split huggingface dataset:
Home blood pressure control status in 2017‐2018 for hypertension specialist centers in Asia: Results of the Asia BP@Home study
Authors: Kario Kazuomi , Tomitani Naoko , Buranakitjaroen Peera , Chia Yook‐Chin , Park Sungha , Chen Chen‐Huan , Divinagracia Romeo , Shin Jinho , Siddique Saulat , Sison Jorge , Ann Soenarta Arieska , Sogunuru Guru Prasad , Tay Jam Chin , Turana Yuda , Zhang Yuqing , Nailes Jennifer , Wanthong Sirisawat , Hoshide Satoshi , Matsushita Noriko , Kanegae Hiroshi , Wang Ji‐Guang ,   HOPE Asia Network
Published: November 2018

A self‐measured home blood pressure (BP)‐guided strategy is an effective practical approach to hypertension management. The Asia BP@Home study is the first designed to investigate current home BP control status in different Asian countries/regions using standardized home BP measurements taken with the same validated home BP monitoring device with data memory. We enrolled 1443 medicated hypertensive patients from 15 Asian specialist centers in 11 countries/regions between April 2017 and March 2018. BP was relatively well controlled in 68.2% of patients using a morning home systolic BP (SBP) cutoff of <135 mm Hg, and in 55.1% of patients using a clinic SBP cutoff of <140 mm Hg. When cutoff values were changed to the 2017 AHA/ACC threshold (SBP <130 mm Hg), 53.6% of patients were well controlled for morning home SBP. Using clinic 140 mm Hg and morning home 135 mm Hg SBP thresholds, the proportion of patients with well‐controlled hypertension (46%) was higher than for uncontrolled sustained (22%), white‐coat (23%), and masked uncontrolled (9%) hypertension, with significant country/regional differences. Home BP variability in Asian countries was high, and varied by country/region. In conclusion, the Asia BP@Home study demonstrated that home BP is relatively well controlled at hypertension specialist centers in Asia. However, almost half of patients remain uncontrolled for morning BP according to new guidelines, with significant country/regional differences. Strict home BP control should be beneficial in Asian populations. The findings of this study are important to facilitate development of health policies focused on reducing cardiovascular complications in Asia.
Molecular basis for Poria cocos mushroom polysaccharide used as an antitumour drug in China
Authors: Li Xiulian , He Yanli , Zeng Pengjiao , Liu Yong , Zhang Meng , Hao Cui , Wang Hua , Lv Zhihua , Zhang Lijuan 
Published: November 2018

AbstractPoria cocos is an edible medicinal fungus known as “Fuling” in Chinese and has been used as a Chinese traditional medicine for more than two thousand years. Pharmacological studies reveal that polysaccharide is the most abundant substance in Poria cocos and has a wide range of biological activities including antitumour, immunomodulation, anti‐inflammation, antioxidation, anti‐ageing, antihepatitis, antidiabetics and anti‐haemorrhagic fever effects. As a result, “Poria cocos polysaccharide oral solution” was developed and sold as an over‐the‐counter health supplement since 1970s. In 2015, “Polysaccharidum of Poria cocos oral solution” was approved as a drug by Chinese Food and Drug Administration for treating multiple types of cancers, hepatitis and other diseases alone or during chemo‐ or radiation therapy for patients with cancer. In this article, biochemical, preclinical and clinical studies of Poria cocos polysaccharide from 72 independent studies during the past 46 years (1970‐2016) based on PubMed, VIP (Chongqing VIP Chinese Scientific Journals Database), CNKI (China National Knowledge Infrastructure) and Wanfang database searches are summarized. The structure, pharmacological effects, clinical efficacy, immunobalancing molecular mechanism and toxicity of Poria cocos polysaccharide are deliberated to provide a general picture of Poria cocos polysaccharide as a clinically used antitumour drug.
MiR‐130b promotes the progression of oesophageal squamous cell carcinoma by targeting SASH1
Authors: Zhu Yuxing , Ma Yanni , Peng Honghua , Gong Lian , Xiao Mengqin , Xiang Liang , He Dong , Cao Ke 
Published: November 2018

AbstractMiR‐130b and SAM and SH3 domain containing 1 (SASH1) play an important role in many types of human cancers. The aim of our research was to study their interactions in the process of the proliferation and aggressiveness of oesophageal squamous cell carcinoma (ESCC) cells. Microarray analysis was done to screen the differentially expressed genes in the ESCC tissues. miR‐130b and SASH1 mRNA levels in the ESCC tissues and cells were detected by qRT‐PCR. Dual luciferase reporter system was used to verify the target relationship between miR‐130b and SASH1. The effects of miR‐130b on SASH1 expression were explored by western blot in KYSE30 and TE1 cell lines. CCK‐8 assay, flow cytometry, Transwell, and wound healing assays were conducted to explore the effects of miR‐130b and SASH1 in vitro. In addition, in vivo experiments were conducted to study the roles of miR‐130b and SASH1. miR‐130b was highly expressed, while SASH1 was the opposite in both the ESCC tissues and cells. The expression of SASH1 was inhibited by the direct binding of miR‐130b. The inhibition of miR‐130b reduced the proliferation and aggressiveness of ESCC cells, while it also induced apoptosis and cell cycle arrest in the ESCC cells by suppressing SASH1. The in vivo assay suggested that the overexpression of miR‐130b promoted the growth of ESCC tumours. MiR‐130b was up‐regulated in the ESCC tumour tissues and cells, acting as a tumour promoter. A stimulating effect was demonstrated on ESCC cell growth and aggressiveness by suppressing SASH1, which is an anti‐oncogene.
Vildagliptin improves high glucose‐induced endothelial mitochondrial dysfunction via inhibiting mitochondrial fission
Authors: Liu Hengdao , Xiang Hong , Zhao Shaoli , Sang Haiqiang , Lv Fenghua , Chen Ruifang , Shu Zhihao , Chen Alex F. , Chen Shuhua , Lu Hongwei 
Published: November 2018

AbstractThe dipeptidyl peptidase 4 inhibitor vildagliptin (VLD), a widely used anti‐diabetic drug, exerts favourable effects on vascular endothelium in diabetes. We determined for the first time the improving effects of VLD on mitochondrial dysfunction in diabetic mice and human umbilical vein endothelial cells (HUVECs) cultured under hyperglycaemic conditions, and further explored the mechanism behind the anti‐diabetic activity. Mitochondrial ROS (mtROS) production was detected by fluorescent microscope and flow cytometry. Mitochondrial DNA damage and ATP synthesis were analysed by real time PCR and ATPlite assay, respectively. Mitochondrial network stained with MitoTracker Red to identify mitochondrial fragmentation was visualized under confocal microscopy. The expression levels of dynamin‐related proteins (Drp1 and Fis1) were determined by immunoblotting. We found that VLD significantly reduced mtROS production and mitochondrial DNA damage, but enhanced ATP synthesis in endothelium under diabetic conditions. Moreover, VLD reduced the expression of Drp1 and Fis1, blocked Drp1 translocation into mitochondria, and blunted mitochondrial fragmentation induced by hyperglycaemia. As a result, mitochondrial dysfunction was alleviated and mitochondrial morphology was restored by VLD. Additionally, VLD promoted the phosphorylation of AMPK and its target acetyl‐CoA carboxylase in the setting of high glucose, and AMPK activation led to a decreased expression and activation of Drp1. In conclusion, VLD improves endothelial mitochondrial dysfunction in diabetes, possibly through inhibiting Drp1‐mediated mitochondrial fission in an AMPK‐dependent manner.
Advances in evidence‐based medicine for immunotherapy of non‐small cell lung cancer
Authors: Dong Jingsi , Li Bingjie , Zhou Qinghua , Huang Depei 
Published: November 2018

AbstractTumor immunotherapy is praised as “green therapy,” which can attack tumor by mobilizing immune system. By removing the inhibition of immune cells, checkpoint inhibitors help T cells to identify and kill tumor cells. In recent years, more and more attention has been paid to its effectiveness as a tumor therapy with a large number of clinical data. Currently, inhibitors of 2 checkpoints, CTLA‐4 and PD‐1/PD‐L1, have been approved to be listed. In particular, the latter has achieved breakthrough progress in non‐small cell lung cancer in recent years, bringing about changes in the therapeutic strategy of lung cancer, as well as challenges to the evaluation criteria. This article focuses on the latest immunotherapy methods for lung cancer. The purpose of this article is to summarize the development of evidence‐based medicine for lung cancer immunotherapy and to provide help for further understanding of lung cancer immunotherapy.
Lipoid pneumonia in an orangutan (Pongo abelii) with chronic respiratory problems
Authors: Novacco Marilisa , Hofmann‐Lehmann Regina , Hetzel Udo , Hatt Jean‐Michel , Ohlerth Stefanie , Stirn Martina 
Published: November 2018

AbstractAn orangutan (Pongo abelii) presented with chronic respiratory problems. Cytological evaluation of the bronchoalveolar lavage fluids revealed macrophages with well‐circumscribed intracytoplasmic clear vacuoles and lipid droplets in the background, confirmed by Oil Red O staining. The findings were indicative of lipoid pneumonia. This is the first report of lipoid pneumonia in an orangutan.
High carbon storage in carbon‐limited trees
Authors: Weber Raphael , Gessler Arthur , Hoch Günter 
Published: November 2018

Summary

The concentrations of nonstructural carbohydrates (NSCs) in plant tissues are commonly used as an indicator of total plant carbon (C) supply; but some evidence suggests the possibility for high NSC concentrations during periods of C limitation. Despite this uncertainty, NSC dynamics have not been investigated experimentally under long‐term C limitation.

We exposed saplings of 10 temperate tree species differing in shade tolerance to 6% of ambient sunlight for 3 yr to induce C limitation, and also defoliated one species, Carpinus betulus, in the third season. Growth and NSC concentrations were monitored to determine C allocation.

Shade strongly reduced growth, but after an initial two‐fold decrease, NSC concentrations of shaded saplings recovered to the level of unshaded saplings by the third season. NSC concentrations were generally more depleted under shade after leaf flush, and following herbivore attacks. Only under shade did artificial defoliation lead to mortality and depleted NSC concentrations in surviving individuals.

We conclude that, irrespective of shade tolerance, C storage is maintained under prolonged shading, and thus high NSC concentrations can occur during C limitation. Yet, our results also suggest that decreased NSC concentrations are indicative of C limitation, and that additional leaf loss can lead to lethal C shortage in deep shade.
Differential modulations of reward expectation on implicit facial emotion processing: ERP evidence
Authors: Wu Lulu , Müller Hermann J. , Zhou Xiaolin , Wei Ping 
Published: November 2018

AbstractImplicit emotional processing refers to the preferential processing of emotional content even if it is task irrelevant. Given that motivation enhances executive control by biasing attentional resources toward target stimuli, here we investigated the effects of reward expectation on implicit facial emotional processing in two experiments using ERPs. A precue signaling additional monetary reward for fast and accurate response for the upcoming trial (incentive condition; relative to a cue indicating no such additional reward, i.e., nonincentive condition) was followed by the presentation of a happy, angry, or neutral face. Participants had to determine the gender of the face in Experiment 1 and decide whether a number superimposed on the face was even or odd in Experiment 2. In both experiments, incentive cues elicited larger P3 and contingent negative variation responses, and the targets following incentive cues elicited more positive‐going ERPs (200–700 ms), compared with the nonincentive condition. Importantly, the N2 responses (200–280 ms) to the target exhibited differential patterns of Reward × Emotion interaction: relative to the nonincentive condition, the N2 amplitude differences between emotional (i.e., happy and/or angry) and neutral faces increased in the incentive condition in Experiment 1, but diminished in Experiment 2. These results indicate that reward expectation can differentially modulate implicit processing of facial expressions, with increased sensitivity to emotions when the processing of whole faces is required, but with reduced sensitivity when the processing of faces is distractive. This study enriches the evidence for interactions between reward‐related executive control and implicit emotional processing.
Effect of CPAP on airway reactivity and airway inflammation in children with moderate–severe asthma
Authors: Praca Eduardo , Jalou Hasnaa , Krupp Nadia , Delecaris Angela , Hatch Joseph , Slaven James , Gunst Susan J. , Tepper Robert S. 
Published: November 2018

ABSTRACTBackground and objectiveAsthma is characterized by airway hyperreactivity and airway inflammation. We previously demonstrated that adults with mild well‐controlled asthma exhibited a marked decrease in airway reactivity (PC20 increased >2‐fold) after using nocturnal continuous positive airway pressure (CPAP) for 1 week. If CPAP produces a similar suppression of airway reactivity in children with moderate–severe asthma, who require chronic use of corticosteroids, then this non‐pharmacological therapy might provide a beneficial alternative or supplemental therapy in these subjects.MethodsChildren aged 8–17 years with moderate–severe asthma were treated with 4 weeks of nocturnal CPAP (8–10 cm H2O) or sham CPAP (<2 cm H2O). Adherence was monitored with a modem installed in the equipment or by memory cards. Airway reactivity, assessed by methacholine bronchial challenge, was measured prior to and following treatment.ResultsThe percentage of subjects adherent to treatment was similar in both groups (19/27 CPAP vs 19/28 sham, ~70%). There was a tendency for PC20 to increase with treatment in both groups (3.0–5.3 mg/mL CPAP vs 3.2 to 4.3 mg/mL sham, P = 0.083); however, the change did not differ significantly between groups (P = 0.569).ConclusionWe found that the 4‐week treatment with nocturnal CPAP did not produce a twofold suppression of airway reactivity in children with moderate–severe asthma.
Construction of Row–Column Factorial Designs
Authors: Godolphin J. D. 
Published: November 2018

SummaryThe arrangement of 2n-factorials in row–column designs to estimate main effects and two-factor interactions is investigated. Single-replicate constructions are given which enable estimation of all main effects and maximize the number of estimable two-factor interactions. Constructions and guidance are given for multireplicate designs in single arrays and in multiple arrays. Consideration is given to constructions for 2n − t fractional factorials.
Systematic review of factors associated with the development of Guillain–Barré syndrome 2007–2017: what has changed?
Authors: Wachira Virginia Kagure , Peixoto Henry Maia , de Oliveira Maria Regina Fernandes 
Published: November 2018

AbstractObjectiveThe objective of this study was to describe the factors associated with the development of Guillain–Barré syndrome, both infectious and non‐infectious, during and after the A(H1N1) influenza pandemic in 2009 and the recent Zika virus epidemic in the Americas.MethodSystematic review of literature on factors associated with the development of the Guillain–Barré syndrome published between 2007 and 2017 listed in EBSCO, MEDLINE and LILACS databases. The quality of the studies was evaluated using the Newcastle Ottawa Scale.ResultsThirty‐four articles met inclusion criteria and were selected for analysis. Their quality was considered good in relation to most of the items evaluated. Many aetiological agents had the results of association with Guillain–Barré syndrome, among them Campylobacter jejuni, influenza vaccine – both pandemic and seasonal vaccines, respiratory infection, gastrointestinal infection among others. The aetiological agents found are, in most part, the same reported prior to the study period. The association with surgeries, chikungunya virus (CHIKV), Zika virus and quadrivalent human papillomavirus vaccine stand out as new aetiological agents in the list of the various possible agents that trigger Guillain–Barré syndrome reported in the study period. There were no Brazilian studies identified during this period.ConclusionsThe results of the review reaffirmed C. jejuni as the major trigger of GBS, whereas the association of influenza vaccines and GBS is less clear; Zika virus infection in association with GBS was found in only one study.
Minimally invasive percutaneous medial plate‐rod osteosynthesis for treatment of humeral shaft fractures in dog and cats: Surgical technique and prospective evaluation
Authors: Guiot Laurent P. , Guillou Reunan P. , Déjardin Loïc M. 
Published: November 2018

AbstractObjectiveTo describe and prospectively report outcomes associated with a novel minimally invasive percutaneous osteosynthesis (MIPO) technique for the treatment of humeral fractures in dogs and cats.Study designProspective clinical case series.AnimalsEleven dogs and 4 cats with traumatic nonarticular humeral fractures.MethodsDogs and cats that presented with traumatic humeral fractures were enrolled in the study. After closed reduction, the fracture was stabilized by using a plate‐rod combination applied via remote medial incisions. Postoperative alignment in the frontal and sagittal planes was statistically compared with the contralateral limbs. Time to clinical union and complications were also recorded.ResultsEleven dogs and 4 cats were included in this study. Body weight ranged from 4.5 to 33.6 kg in dogs and from 2.2 to 3.6 kg in cats. A veterinary cuttable plate (6/11 dogs and 3/4 cats) or locking compression plate was used in a plate‐rod configuration (11/11 dogs and 2/4 cats) or alone (2/4 cats). Rod‐to‐medullary‐cavity ratio was 30%. Plate‐span ratio was 5.8 (range, 2‐13.5). No significant differences were found in frontal or sagittal plane alignment. Healing time in cases that completed on‐time follow‐up (12/15) was 36 ± 14 days (range, 20‐69). No major complications were recorded.ConclusionThe reported technique was associated with good outcomes in a large variety of fracture configurations and animal sizes, with no complications.Clinical significanceThis report provides evidence that MIPO is a compelling alternative to open reduction and internal fixation in the treatment of various humeral fractures.
A model of reaeration rates driven by shear flows
Authors: Duan Zhiyong 
Published: November 2018

AbstractThe reaeration rate determines the speed that the dissolved oxygen is restored to the saturation level. The reaeration rate is determined by the surface renewal rates from the friction interfaces in the water bodies, including the water/bed interface, the shear‐flow interface and the air/water interface. The formulae of reaeration rate for the air/water interface and the water/bed interface were developed in prior studies. However, no formula of the reaeration rate driven by the shear flows was developed. In this study, a mechanic model of the reaeration rate driven by the shear flows is developed to fill in the gap. The flow velocity profile in the shear flows and the Surface Renewal Theory are employed to derive the corresponding model. The predictions of the formulae for these three types of friction interfaces are compared for the same phase velocity to investigate the reasonability of the reaeration rate model for the shear‐flow interface. The predictions of the model for the shear‐flow interface are between those for the air/water interface and for the water/bed interface. The model in this study is also verified to have reasonable agreements with the experimental data. The model developed in this study can be applied for the prediction of the low soluble gases’ transfer rate between air and water in shear flows.
Effectiveness of Silexan oral lavender essential oil compared to inhaled lavender essential oil aromatherapy for sleep in adults: a systematic review
Authors: Greenberg Martha J. , Slyer Jason T. 
Published: November 2018

ABSTRACT

Objective:
The objective of the review was to identify the effectiveness of Silexan oral lavender essential oil compared to inhaled lavender essential oil aromatherapy for sleep latency, sleep duration, sleep quality, disturbed sleep and anxiety in adult patients.

Introduction:
Insomnia is a common problem, with 10–20% of the global population using sleep aids. Benzodiazepine and non-benzodiazepine sleep aids have the potential to cause side effects which may result in falls or other injuries. Lavender oil has anxiolytic properties that may improve sleep and reduce anxiety without the potential for adverse reaction. Silexan, an oral pill produced from lavender essential oil, has limited availability. This review sought to determine if lavender essential oil aromatherapy was as effective as Silexan to enable promotion of the use of essential oil aromatherapy in markets where Silexan is not available.

Inclusion criteria:
This review considered both experimental and epidemiological studies that included participants 18 years and over utilizing Silexan therapy of any dose or duration compared to inhaled lavender essential oil aromatherapy. The outcomes of interest were sleep latency, sleep duration, sleep quality, disturbed sleep and anxiety.

Methods:
A comprehensive search strategy aimed to find relevant published and unpublished quantitative English language studies from 2010 through to February 16, 2018. Databases searched included: PubMed, CINAHL, Cochrane Central Register of Controlled Trials and Embase. A search of gray literature was also performed.

Results:
No studies were identified that met the inclusion criteria.

Conclusions:
A comprehensive search of the literature uncovered no evidence related to the effectiveness of Silexan compared to inhaled lavender essential oil aromatherapy for sleep latency, sleep duration, sleep quality, disturbed sleep or anxiety in adult patients. Research is needed to determine if lavender essential oil aromatherapy, which is readily available worldwide, can be proven to be as effective as Silexan for improving sleep and anxiety in adult patients.