bluuebunny/crossref_metadata_2025_split huggingface dataset:
Descripción, ampliación y nuevo registro de distribución para Dendropsophus manonegra (Rivera & Orrico, 2013) y Dendropsophus sarayacuensis (Shreve, 1935) (Amphibia: Anura: Hylidae) en el piedemonte andino-amazónico del departamento de Caquetá, Colombia
Authors: Navarro-Morales Alejandro , Ruiz-Valderrama Diego Huseth 
Published: October 2019

Se presentan la ampliación y nuevos registros de distribución de dos especies de la familia Hylidae pertenecientes al género Dendropsophus en la región andino-amazónica del departamento del Caquetá, Colombia. Los registros se hicieron en tres localidades del municipio de Florencia: vereda Villaraz, vereda Paraíso y vereda La Holanda, y dos del municipio de Belén de los Andaquíes: Resguardo Indígena La Serinda y vereda Agua Dulce. Utilizando el método de encuentro visual desde las 19:00 a las 23:00 se recolectaron 38 individuos de Dendropsophus manonegra y tres de Dendropsophus sarayacuensis; se hizo la descripción taxonómica de los individuos en vida y preservados. Se discuten, además, las variaciones altitudinales en las que se pueden encontrar estos organismos a partir de investigaciones de diferentes autores. Estos nuevos registros son fundamentales para el conocimiento de la herpetofauna colombiana, en especial la del departamento del Caquetá.
Food Choice Under Five Front-of-Package Nutrition Label Conditions: An Experimental Study Across 12 Countries
Authors: Talati Zenobia , Egnell Manon , Hercberg Serge , Julia Chantal , Pettigrew Simone 
Published: October 2019

Objectives. To determine which front-of-package label (out of 5 formats) is most effective at guiding consumers toward healthier food choices. Methods. Respondents from Argentina, Australia, Bulgaria, Canada, Denmark, France, Germany, Mexico, Singapore, Spain, the United Kingdom, and the United States took part in the Front-of-Pack International Comparative Experiment between April and July 2018. Respondents were shown foods of varying nutritional quality (with no label on package) and selected which they would be most likely to purchase. The same choice sets were then shown again with 1 of 5 randomly allocated labels on package (Health Star Rating (HSR), Multiple Traffic Lights (MTL), Nutri-Score, Reference Intakes, or Warning Label). We calculated an improvement score (from 11 100 valid responses) to identify the extent to which the labels produced healthier choices. Results. The most effective labels were the Nutri-Score and the MTL (mean improvement score = 0.09; 95% confidence interval [CI] = 0.07, 0.11), then the Warning Label (0.06; 95% CI = 0.04, 0.08), the HSR (0.05; 95% CI = 0.03, 0.07), and lastly the Reference Intakes (0.04; 95% CI = 0.02, 0.04). Conclusions. Well-designed, salient, and intuitive front-of-package labels can be effective on a global scale. Their impact is not bound to the country from which they originate.
Demand for Self-Managed Medication Abortion Through an Online Telemedicine Service in the United States
Authors: Aiken Abigail R. A. , Starling Jennifer E. , van der Wal Alexandra , van der Vliet Sascha , Broussard Kathleen , Johnson Dana M. , Padron Elisa , Gomperts Rebecca , Scott James G. 
Published: October 2019

Objectives. To examine demand for abortion medications through an online telemedicine service in the United States. Methods. We examined requests from US residents to the online telemedicine abortion service Women on Web (WoW) between October 15, 2017, and August 15, 2018. We calculated the population-adjusted rate of requests by state and examined the demographics, clinical characteristics, and motivations of those seeking services, comparing those in states with hostile versus supportive abortion policy climates. Results. Over 10 months, WoW received 6022 requests from US residents; 76% from hostile states. Mississippi had the highest rate of requests (24.9 per 100 000 women of reproductive age). In both hostile and supportive states, a majority (60%) reported a combination of barriers to clinic access and preferences for self-management. Cost was the most common barrier (71% in hostile states; 63% in supportive states; P < .001). Privacy was the most common preference (49% in both hostile and supportive states; P = .66). Conclusions. Demand for self-managed medication abortion through online telemedicine is prevalent in the United States. There is a public health justification to make these abortions as safe, effective, and supported as possible.
Symptomatic Thromboembolic Complications After Shoulder Arthroplasty
Authors: Kolz Joshua M. , Aibinder William R. , Adams Robert A. , Cofield Robert H. , Sperling John W. 
Published: October 2019

Background:
Venous thromboembolism (VTE) complications, including deep vein thrombosis and pulmonary embolism, are dreaded complications of orthopaedic surgical procedures that can result in substantial morbidity and mortality. There is a paucity of data examining risk factors for VTE in shoulder arthroplasty. The purpose of the present study was to review the rate of symptomatic VTE, determine patient and operative risk factors for VTE, and report on complications associated with VTE following shoulder arthroplasty.

Methods:
Over a 16-year period, 5,906 patients underwent primary anatomic total shoulder arthroplasty, reverse total shoulder arthroplasty, or hemiarthroplasty. Symptomatic VTE events were identified in 24 shoulders within 90 days of surgery. Patient records were reviewed for surgical indication, patient and operative risk factors, and management of VTE.

Results:
The rate of symptomatic VTE following shoulder arthroplasty was 0.41%. There were no deaths resulting from VTE events. Compared with patients who did not have VTE, those with symptomatic VTE events were found to be older (74.75 versus 68.51 years; p = 0.0028) and more likely to have had arthroplasty for a traumatic indication (3.31% versus 0.33%; p < 0.001). Age of >70 years and arthroplasty for a traumatic indication were found to be independent risk factors on multivariate nominal logistic regression analysis, whereas body mass index, sex, operative time, and type of arthroplasty performed were not found to be independent risk factors. There were 11 readmissions resulting directly from the VTE events, and patients diagnosed with VTE as inpatients had longer hospital stays than outpatients (13.71 versus 1.94 days; p = 0.0002).

Conclusions:
The risk of VTE following shoulder arthroplasty is low, and routine use of pharmacologic VTE prophylaxis may not be necessary. However, VTE complications can lead to substantial morbidity, longer hospital stays, readmission to the hospital, and further complications. Therefore, patients with multiple risk factors for VTE such as prior history of VTE, active malignancy, age of >70 years, or arthroplasty for traumatic indications should be considered for pharmacologic VTE prophylaxis.

Level of Evidence:
Therapeutic Level IV. See Instructions for Authors for a complete description of levels of evidence.
Use of the United States Medical Licensing Examination Step-1 Score as a Screening Tool for Orthopaedic Surgery Away Rotations
Authors: Huebner Christian , Adnan Mohamed , Kraeutler Matthew J. , Brown Symone , Mulcahey Mary K. 
Published: October 2019

Background:
Orthopaedic surgery has become an increasingly competitive specialty for medical students applying to residency. Aside from residency interviews, away rotations are one of the only opportunities for residency programs to qualitatively evaluate an applicant. The purpose of this study was to determine if residency program directors (PDs) use a minimum United States Medical Licensing Examination (USMLE) Step-1 score as a screening tool for students applying for away rotations at their institution.

Methods:
An anonymous 12-question survey about residency selection criteria and which criteria are used to select applicants for away rotations was distributed to PDs at U.S. allopathic orthopaedic surgery residency programs who are members of the Council of Orthopaedic Residency Directors (CORD). Questions included information on minimum USMLE Step-1 scores, the number of students who complete away rotations at the program each year, and how applicants are selected for rotations.

Results:
Survey responses were received from 87 (58%) of 149 PDs. Seventy-one (82%) of these PDs reported that their program uses a minimum Step-1 score for residency applications, with the most common cutoff score being between 231 and 240 (as answered by 33 [46%] of 72 PDs). Twenty-seven (31%) of 87 PDs reported that if a student does not meet their residency minimum Step-1 score, he or she is not offered the opportunity to rotate at the program. Eleven (25%) of 44 PDs reported that they do not inform students when their score is below the program’s minimum.

Conclusions:
A substantial proportion of orthopaedic surgery residency PDs use the USMLE Step-1 score as a screening tool for students interested in doing away rotations at their programs. If a student’s Step-1 score does not meet the program’s minimum, the majority of programs still will allow the student to rotate at their institution. Students should take this information into account when selecting away rotations in order to maximize their chances of matching into an orthopaedic surgery program.
The Proximal Humeral Ossification System Improves Assessment of Maturity in Patients with Scoliosis
Authors: Li Don T. , Linderman George C. , Cui Jonathan J. , DeVries Stephen , Nicholson Allen D. , Li Eric , Petit Logan , Kahan Joseph B. , Talty Ronan , Kluger Yuval , Cooperman Daniel R. , Smith Brian G. 
Published: October 2019

Background:
We recently developed a classification system to assess skeletal maturity by scoring proximal humeral ossification in a similar way to the canonical Risser sign. The purpose of the present study was to determine whether our system can be used to reliably assess radiographs of the spine for modern patients with idiopathic scoliosis, whether it can be used in combination with the Sanders hand system, and whether the consideration of patient factors such as age, sex, and standing height improves the accuracy of predictions.

Methods:
We retrospectively reviewed 414 randomized radiographs from 216 modern patients with scoliosis and measured reliability with use of the intraclass correlation coefficient (ICC). We then analyzed 606 proximal humeral radiographs for 70 children from a historical collection to determine the value of integrating multiple classification systems. The age of peak height velocity (PHV) was predicted with use of linear regression models, and performance was evaluated with use of tenfold cross-validation.

Results:
The proximal humeral ossification system demonstrated excellent reliability in modern patients with scoliosis, with an ICC of 0.97 and 0.92 for intraobserver and interobserver comparisons, respectively. The use of our system in combination with the Sanders hand system yielded 7 categories prior to PHV and demonstrated better results compared with either system alone. Linear regression algorithms showed that integration of the proximal part of the humerus, patient factors, and other classification systems outperformed models based on canonical Risser and triradiate-closure methods.

Conclusions:
Humeral head ossification can be reliably assessed in modern patients with scoliosis. Furthermore, the system described here can be used in combination with other parameters such as the Sanders hand system, age, sex, and height to predict PHV and percent growth remaining with high accuracy.

Clinical Relevance:
The proximal humeral ossification system can improve the prediction of PHV in patients with scoliosis on the basis of a standard spine radiograph without a hand radiograph for the determination of bone age. This increased accuracy for predicting maturity will allow physicians to better assess patient maturity relative to PHV and therefore can help to guide treatment decision-making without increasing radiation exposure, time, or cost. The present study demonstrates that assessment of the proximal humeral physis is a viable and valuable aid in the determination of skeletal maturity as obtained from radiographs of the spine that happen to include the shoulder in adolescent patients with idiopathic scoliosis.
BURROWS AND ICHNOFABRIC PRODUCED BY CENTIPEDES: MODERN AND ANCIENT EXAMPLES
Authors: HEMBREE DANIEL I. 
Published: October 2019

ABSTRACTCentipedes extend to the Silurian yet have a relatively poor fossil record. Many species of extant centipedes are semi-fossorial to fossorial and contribute to soil processes, suggesting that their trace fossils should be common in paleosols. The goal of this project was to document the types of biogenic structures produced by two species of large, semi-fossorial centipedes, Hemiscolopendra marginata andScolopendra polymorpha, to aid in the recognition of fossil centipede burrows. Ten specimens of each species were placed in large, sediment-filled terrariums and observed over periods of 14 days. The centipedes burrowed via intrusion, compression, and excavation, moving throughout the enclosure both near the surface and deep within the sediment. Open burrows produced by the centipedes were cast with plaster and the ichnofabric produced was observed through the enclosure walls. The centipedes primarily produced J-, U-, and Y-shaped burrows as well as complexes of linked burrows. The burrows were elliptical in cross section and possessed thin, intermittent, compressional linings. The centipede burrows were compared to burrows of other extant soil arthropods including millipedes, spiders, and scorpions as well as Pennsylvanian to Permian ichnofossils. The centipede burrows were distinct from those of other soil arthropods and many aspects of the ichnofossils were similar to those produced by the centipedes. Description of burrows produced by centipedes can aid in the interpretation of continental ichnofossils and improve our understanding of the composition of ancient soil ecosystems. This knowledge is especially important given the poor preservation potential of centipedes in the environments they inhabit.
Older multimorbid patients’ experiences on integration of services: A systematic review
Authors: Boye Lilian Keene Guldhammer , Mogensen Christian Backer , Mechlenborg Tine , Waldorff Frans Boch , Andersen Pernille Tanggaard 
Published: October 2019

Abstract
Background
Half of the older persons in high-income counties are affected with multimorbidity and the prevalence increases with older age. To cope with both the complexity of multimorbidity and the ageing population health care systems needs to adapt to the aging population and improve the coordination of long-term services. The objectives of this review were to synthezise how older people with multimorbidity experiences integrations of health care services and to identify barriers towards continuity of care when multimorbid.
Methods
A systematic literature search was conducted in February 2018 by in Scopus, Embase, Cinahl, and Medline using the PRISMA guidelines. Inclusion criteria: studies exploring patients’ point of view, ≥65 and multi-morbid. Quality assessment was conducted using COREQ. Thematic synthesis was done.
Results
2030 studies were identified, with 75 studies eligible for full text, resulting in 9 included articles, of generally accepted quality.
Integration of health care services was successful when the patients felt listened to on all the aspects of being individuals with multimorbidity and when they obtained help from a care coordinator to prioritize their appointments. However, they felt frustrated when they did not have easy access to their health providers, when they were not listened to, and when they felt they were discharged too early. These frustrations were also identified as barriers to continuity of care.
Conclusions
Health care systems needs to adapt to people with multimorbidity and find solutions on ways to create flexible systems that are able to help older patients with multimorbidity, meet their individual needs and their desire to be involved in decisions regarding their care. A Care coordinator may be a solution.
Testing non-inferiority of blended versus face-to-face Cognitive Behavioural Therapy for severe fatigue in patients with Multiple Sclerosis and the effectiveness of blended booster sessions aimed at improving long term outcome following both therapies: – study protocol for two observer-blinded randomized clinical trials
Authors: de Gier Marieke Houniet- , Beckerman Heleen , Vliet Kimberley van , Knoop Hans , de Groot Vincent 
Published: October 2019

Abstract
Background: Cognitive behavioural therapy (CBT) has been found effective in reducing fatigue severity in MS patients directly following treatment. However, long-term effects are inconsistent leaving room for improvement. In addition, individual face-to-face CBT draws heavily on limited treatment capacity, and the travel distance to the treatment centre can be burdensome for patients. Therefore, we developed “MS Fit”, a blended CBT for MS-related fatigue, based on a face-to-face CBT protocol found effective in a previous study, and “MS Stay Fit”, internet-based booster sessions to improve long term effectiveness of CBT for MS-related fatigue. This paper presents the protocol of two Randomised Clinical Trials (RCTs) conducted within one study investigating 1) the non-inferiority of MS Fit compared to evidence-based face-to-face CBT for MS-related fatigue, and 2) the effectiveness of MS Stay Fit on the long-term outcome of fatigue compared to no booster sessions.

Methods/design: The first part of this study is an observer-blinded non-inferiority multicentre RCT, in which 166 severely fatigued MS patients will be randomized (1:1 ratio, computer-generated sequence) to either face-to-face CBT or blended CBT (MS Fit) for fatigue. The primary endpoint is at 20 weeks after baseline. After this post-treatment assessment, patients will be randomized again (1:1 ratio, computer generated sequence) to either MS Stay Fit consisting of 2 booster sessions at 2 and 4 months after end of treatment, or no booster sessions. The primary endpoint of the second study is 52 weeks after baseline. Primary outcome measure in both studies is fatigue severity assessed with the fatigue severity subscale of the Checklist Individual Strength (CIS20r). Outcomes will be assessed at baseline (T0), end of treatment (T20), after 39 and 52 weeks (T39 and T52).

Discussion: If MS Fit is found to be non-inferior to face-to-face CBT it will improve the accessibility of this treatment. In addition, the study aims to test if it is possible to improve long-term effectiveness of CBT for MS-related fatigue with MS Stay Fit.
Impact of chemotherapy cycles and intervals on outcomes of nonspinal Ewing sarcoma in adults: a real-world experience
Authors: Zhang Jianjun , Huang Yujing , Sun Yuanjue , He Aina , Zhou Yan , Hu Haiyan , Yao Yang , Shen Zan 
Published: October 2019

Abstract
Abstract

Background: Adult Ewing sarcoma (ES) is a rare disease, the optimal treatment model is unknown. This study aimed to retrospectively analyze treatment-related prognostic factors of nonspinal ES in Chinese adults.

Methods: 81 patients treated between January 2005 and December 2017 were included in the present study. 33 (40.7%) presented with metastatic disease at diagnosis. 8 patients were submitted to primary surgery followed by chemotherapy, while 73 patients received chemotherapy before and after surgery and/or local radiotherapy. The chemotherapy regimen included 8-17 cycles of vincristine, doxorubicin, and cyclophosphamide (VDC) alternating with ifosfamide and etoposide (IE) every 3 weeks. Clinical outcomes and safety were analyzed.

Results: VDC/IE chemotherapy was well tolerated in adult patients with ES. Multivariate Cox regression analyses revealed that chemotherapy of at least 12 cycles was a favorable independent prognostic factor of event-free survival (hazard ratio, 0.558; 95% confidence interval, 0.323-0.965; P = 0.037) and overall survival (hazard ratio, 0.424; 95% confidence interval, 0.240-0.748; P = 0.003). Similarly, a low frequency of chemotherapy delays was an independent prognostic factor of improved OS (hazard ratio, 0.438; 95% confidence interval, 0.217-0.887; P = 0.022).

Conclusion: Our study suggests that adults with ES should be treated with an aggressive multidisciplinary approach, intensive chemotherapy with adequate cycles and appropriate intervals can be recommended in this group.
Developing a High-Performance Liquid Chromatography Fast and Accurate Method for Quantification of Silibinin
Authors: Bakhshi Faezeh , Molavi Ommoleila , Rashidi Mohammad Reza , Shayanfar Ali , Amini Hassan 
Published: October 2019

Abstract
Objective: Silibinin is an antioxidant agent and is shown to have anticancer effects in different cancers including lung, breast, colorectal, liver, prostate, and kidney. There are challenges in the clinical use of silibinin. The main limitation is low solubility, poor oral absorption, and extensive hepatic metabolism. We aim to develop a High-Performance Liquid Chromatography (HPLC) sensitive method for quantification of silibinin in in-vitro samples to quantify its concentration in new formulations. A reverse-phase high-performance liquid chromatography (RP-HPLC) composed of C18 column as stationary phase and the mixture of methanol (90%) and water (10%) as mobile phase. The developed method was validated based on the established guidelines.
Results: The retention time for silibinin was seen in 2.97 minute after injection. The calibration curve was drawn and the established method demonstrated a linear ranged from 10 to 100 µg/ml, with a correlation coefficient of 0.996. The sensitivity of the developed method was 10 µg/ml. The accuracy calculated in the range of 88-105.9% and the precision (as relative standard deviation) was between 2.7-10.9%. These results demonstrate that the developed method can be a fast and accurate method for quantification of silibinin in aqueous samples.
Determinants of late antenatal care follow up among pregnant women in Easter zone Tigray, Northern Ethiopia, 2018. Unmatched case- control study
Authors: Gebremariam Gebrehiwot , Teklehaimanot Berhane Fsseha , Gebru Hurut Teame , Gebrezgi Zinabu Asfaw , Tekola Kidanemaryam Berhe , Baraki Mulu Fitwi 
Published: October 2019

Abstract
Abstract
Objective: The purpose of the study was to identify determinants of late antennal care at first visit in health facilities of eastern zoneof Tigray, Northern Ethiopia 2018.
Result : Women with unplanned pregnancy (AOR= 4.03, 95%, CI: 1.56-5.67),Participants attended first antenatal care visit after 16 weeks for previous pregnancies (AOR= 3.9, 95% CI: 1.98-7.68), Participants did not accompanied by partner for antenatal visit (AOR= 1.29,95%, CI: 1.05-4.67), women who recognized their pregnancy at three months or late ( AOR= 4.7,95%,CI: 2.49-9.04) and participants who provided adequate time for their previous antenatal care by health professionals ( AOR = 0.461, 95% CI 0.342- 0.875) were found the determinant factors of late antenatal care at first Visit. Hence family planning utilization, times of first visit antenatal, information flow and supporting by partners have a great role in improving antenatal care at first visit. There for responsible bodies should give focuses on utilization of family planning, increasing awareness of pregnancy symptoms and health provisional provide adequate time during visits.