bluuebunny/crossref_metadata_2025_split huggingface dataset:
Coronary Thermodilution Waveforms After Acute Reperfused ST‐Segment–Elevation Myocardial Infarction: Relation to Microvascular Obstruction and Prognosis
Authors: Yew Shu Ning , Carrick David , Corcoran David , Ahmed Nadeem , Carberry Jaclyn , Teng Yue May Vannesa , McEntegart Margaret , Petrie Mark C. , Eteiba Hany , Lindsay Mitchell , Hood Stuart , Watkins Stuart , Davie Andrew , Mahrous Ahmed , Mordi Ify , Ford Ian , Oldroyd Keith G. , Berry Colin 
Published: September 2018

Background
Invasive measures of microvascular resistance in the culprit coronary artery have potential for risk stratification in acute ST‐segment–elevation myocardial infarction. We aimed to investigate the pathological and prognostic significance of coronary thermodilution waveforms using a diagnostic guidewire.

Methods and Results

Coronary thermodilution was measured at the end of percutaneous coronary intervention, (PCI) and contrast‐enhanced cardiac magnetic resonance imaging (MRI) was intended on day 2 and 6 months later to assess left ventricular (LV) function and pathology. All‐cause death or first heart failure hospitalization was a pre‐specified outcome (median follow‐up duration 1469 days). Thermodilution recordings underwent core laboratory assessment. A total of 278 patients with acute ST‐segment elevation myocardial infarction EMI (72% male, 59±11 years) had coronary thermodilution measurements classified as narrow unimodal (n=143 [51%]), wide unimodal (n=100 [36%]), or bimodal (n=35 [13%]). Microvascular obstruction and myocardial hemorrhage were associated with the thermodilution waveform pattern (
P
=0.007 and 0.011, respectively), and both pathologies were more prevalent in patients with a bimodal morphology. On multivariate analysis with baseline characteristics, thermodilution waveform status was a multivariable associate of microvascular obstruction (odds ratio [95% confidence interval]=5.29 [1.73, 16.22];,
P
=0.004) and myocardial hemorrhage (3.45 [1.16, 10.26];
P
=0.026), but the relationship was not significant when index of microvascular resistance (IMR) >40 or change in index of microvascular resistance (5 per unit) was included. However, a bimodal thermodilution waveform was independently associated with all‐cause death and hospitalization for heart failure (odds ratio [95% confidence interval]=2.70 [1.10, 6.63];
P
=0.031), independent of index of microvascular resistance>40, ST‐segment resolution, and TIMI (Thrombolysis in Myocardial Infarction) Myocardial Perfusion Grade.

Conclusions
The thermodilution waveform in the culprit coronary artery is a biomarker of prognosis and may be useful for risk stratification immediately after reperfusion therapy.
Dual Healthcare System Use During Episodes of Acute Care Heart Failure Associated With Higher Healthcare Utilization and Mortality Risk
Authors: Axon R. Neal , Gebregziabher Mulugeta , Everett Charles J. , Heidenreich Paul , Hunt Kelly J. 
Published: September 2018

Background

Individuals receiving cross‐system care (dual users) have higher rates of healthcare utilization and worse outcomes for heart failure (
HF
) and other conditions. Individuals can be dual users or single‐system users at different times, though, and little is known about utilization and mortality within discrete episodes of care.

Methods and Results

A retrospective cohort of 3439 patients with 5231 discrete episodes of
HF
exacerbation were identified between 2007 and 2011. Episodes encompassed the period from 2 weeks before an initial
HF
emergency department (
ED
) visit or hospitalization, included any acute care visits within 30 days after initial visit, and ended 30 days after the last acute care visit in the episode chain. All‐cause and
HF
‐specific
ED
visits and hospitalization within 30 days of index visit were analyzed using generalized estimating equations with robust variance. Hazard for death within episodes of acute illness was analyzed using Cox proportional hazards models. In adjusted analyses, dual use acute
HF
episodes were associated with higher odds of all‐cause
ED
visits (odds ratio 1.61, 95% confidence interval [
CI
], 1.33, 1.95),
HF
‐specific
ED
visits, (odds ratio 1.54, 95%
CI
, 1.12, 2.13), all‐cause hospitalization (odds ratio 1.89, 95%
CI
, 1.50, 2.38), and
HF
‐specific hospitalization (odds ratio 1.62, 95%
CI
, 1.15–2.30) as compared with Veterans Health Administration–only episodes of acute
HF
care. Dual use episodes of care were associated with higher hazard for mortality (hazard ratio=1.52, 95%
CI
1.07, 2.16) as compared with all–Veterans Health Administration episodes of care.

Conclusions

Episodes of acute
HF
care spanning across healthcare systems appear to be associated with higher risk of subsequent
ED
visits, hospitalization, and mortality.
Postinfarction Hearts Are Protected by Premature Senescent Cardiomyocytes Via GATA4‐Dependent CCN1 Secretion
Authors: Cui Sumei , Xue Li , Yang Feihong , Dai Shuai , Han Ziqi , Liu Kai , Liu Baoshan , Yuan Qiuhuan , Cui Zhaoqiang , Zhang Yun , Xu Feng , Chen Yuguo 
Published: September 2018

Background
Stress‐induced cell premature senescence participates in a variety of tissue and organ remodeling by secreting such proteins as proinflammatory cytokines, chemokines, and growth factors. However, the role of cardiomyocyte senescence in heart remodeling after acute myocardial infarction has not been thoroughly elucidated to date. Therefore, we sought to clarify the impact of premature myocardial senescence on postinfarction heart function.

Methods and Results

Senescence markers, including p16

INK

4a
, p21

CIP

1/

WAF

1
, and
SA
‐β‐gal staining, were analyzed in several heart disease models by immunostaining. Both postinfarction mouse hearts and ischemic human myocardium demonstrated increased senescence markers. Additionally, senescence‐related secretory phenotype was activated after acute myocardial infarction, which upregulated senescence‐related secretory phenotype factors, including
CCN
family member 1 (
CCN
1), interleukin‐1α, tumor necrosis factor α, and monocyte chemoattractant protein‐1. In vivo, a tail vein injection of
AAV
9‐
Gata4
‐sh
RNA
significantly attenuated senescence‐related secretory phenotype secretion and aggravated postinfarction heart dysfunction. Furthermore, among activated senescence‐related secretory phenotype factors,
CCN
1 administration reduced myofibroblast viability in vitro and rescued the deleterious effect of
AAV
9‐
Gata4
‐sh
RNA
in vivo.

Conclusions

Myocardial premature senescence was observed in the ischemic hearts and improved postinfarction heart function, partly through the GATA‐binding factor 4‐
CCN
1 pathway.
Minimal important change and patient acceptable symptom state for patients after proximal interphalangeal joint arthroplasty
Authors: Marks Miriam , Hensler Stefanie , Wehrli Martina , Schindele Stephan , Herren Daniel B. 
Published: September 2018

Our aim was to determine the minimal important change and patient acceptable symptom state for pain and the brief Michigan Hand Outcomes Questionnaire in patients 1 year after proximal interphalangeaI joint arthroplasty. We analysed data of 100 patients from our prospective registry. The minimal important change and patient acceptable symptom state were determined with anchor-based methods, and patients with better or worse baseline status were examined. The minimal important change for pain at rest and during activities, and the brief Michigan Hand Outcomes Questionnaire was −1.2, −2.8 and 18, respectively, with corresponding patient acceptable symptom state values of 1.5, 2.5 and 64. Patients with higher baseline symptoms rated more severe postoperative symptoms as acceptable, whereas patients with lower baseline symptoms were only satisfied with a low level of pain and high level of hand function. The minimal important change and patient acceptable symptom state are useful estimates for patient outcomes and study results. Level of evidence: IV
Extracellular Matrix Determines Biomechanical Properties of Chondrospheres during Their Maturation In Vitro
Authors: Omelyanenko Nikolai P. , Karalkin Pavel A. , Bulanova Elena A. , Koudan Elizaveta V. , Parfenov Vladislav A. , Rodionov Sergei A. , Knyazeva Alisa D. , Kasyanov Vladimir A. , Babichenko Igor I. , Chkadua Tamara Z. , Khesuani Yusef D. , Gryadunova Anna A. , Mironov Vladimir A. 
Published: September 2018

Objective Chondrospheres represent a variant of tissue spheroids biofabricated from chondrocytes. They are already being used in clinical trials for cartilage repair; however, their biomechanical properties have not been systematically investigated yet. The aim of our study was to characterize chondrospheres in long-term in vitro culture conditions for morphometric changes, biomechanical integrity, and their fusion and spreading kinetics. Results It has been demonstrated that the increase in chondrospheres secant modulus of elasticity is strongly associated with the synthesis and accumulation of extracellular matrix. Additionally, significant interplay has been found between biomechanical properties of tissue spheroids and their fusion kinetics in contrast to their spreading kinetics. Conclusions Extracellular matrix is one of the main structural determinants of chondrospheres biomechanical properties during chondrogenic maturation in vitro. The estimation of tissue spheroids’ physical behavior in vitro prior to operative treatment can be used to predict and potentially control fusogenic self-assembly process after implantation in vivo.
Arthroscopic Meniscopexy for the Treatment of Nontraumatic Osteochondritis Dissecans in the Knee Joint of Adult Patients
Authors: Blanke Fabian , Feitenhansl Andreas , Haenle Maximilian , Vogt Stephan 
Published: September 2018

Objective The etiology of osteochondritis dissecans (OCD) is still uncertain. Recently, it has been hypothesized that instability of the anterior horn of the meniscus is an important cause for the development of a nontraumatic OCD in adolescents with good results after surgical stabilization. This case series aims to evaluate the treatment results after meniscus stabilization in adults with nontraumatic OCD. Design Ten patients with magnetic resonance imaging (MRI)-confirmed OCD of the knee joint, meniscal instability, and closed epiphyseal plates were enrolled in this study. The instable meniscus was stabilized by direct suturing of the anterior horn of the meniscus. MRI examinations were performed preoperative and 6 and 12 months postoperative. The OCD was classified arthroscopically according to Guhl and according to Hughes in the MRI. The overall knee function was evaluated by the Lysholm score before treatment and 12 months postoperative. Results Four women and 6 men with a mean age of 20.6 ± 1.9 years were included in this study. Preoperatively 60% of the patients showed a grade II or III lesion arthroscopically and 70% a grade III or IVa lesion in the MRI examination. After arthroscopic meniscus stabilization the Lysholm score increased in average from 48.1 ± 14.12 before treatment to 97.5 ± 3.1 postoperative. At final follow-up after 12 months, an improvement of the OCD in the MRI could be demonstrated in all patients (100%). In 80% of the patients a complete healing of the OCD could be noted. Conclusion The clinical concept of an instable anterior horn of the meniscus as a cause for the development of a nontraumatic OCD seems to be transferable to adults and arthroscopic stabilization can lead to a sufficient healing of this knee pathology.
Budesonide/formoterol MDI with co-suspension delivery technology in COPD: the TELOS study
Authors: Ferguson Gary T. , Papi Alberto , Anzueto Antonio , Kerwin Edward M. , Cappelletti Christy , Duncan Elizabeth A. , Nyberg Jack , Dorinsky Paul 
Published: September 2018

TELOS compared budesonide (BD)/formoterol fumarate dihydrate (FF) metered dose inhaler (BFF MDI), formulated using innovative co-suspension delivery technology that enables consistent aerosol performance, with its monocomponents and budesonide/formoterol fumarate dihydrate dry powder inhaler (DPI) in patients with moderate to very severe chronic obstructive pulmonary disease (COPD), without a requirement for an exacerbation history.In this phase III, double-blind, parallel-group, 24-week study (NCT02766608), patients were randomised to BFF MDI 320/10 µg (n=664), BFF MDI 160/10 µg (n=649), FF MDI 10 µg (n=648), BD MDI 320 µg (n=209) or open-label budesonide/formoterol DPI 400/12 µg (n=219). Primary end-points were change from baseline in morning pre-dose trough forced expiratory volume in 1 s (FEV1) and FEV1area under the curve from 0–4 h (AUC0–4). Time to first and rate of moderate/severe exacerbations were assessed.BFF MDI 320/10 µg improved pre-dose trough FEV1versusFF MDI (least squares mean (LSM) 39 mL; p=0.0018), and BFF MDI 320/10 µg and 160/10 µg improved FEV1AUC0–4versusBD MDI (LSM 173 mL and 157 mL, respectively; both p<0.0001) at week 24. BFF MDI 320/10 µg and 160/10 µg improved time to first and rate of moderate/severe exacerbationsversusFF MDI. Treatments were well tolerated, with pneumonia incidence ranging from 0.5–1.4%.BFF MDI improved lung functionversusmonocomponents and exacerbationsversusFF MDI in patients with moderate to very severe COPD.
Zero Degree Everything: An Interview with Tom McCarthy
Authors: Huber Nicholas 
Published: September 2018

Abstract
In this interview, Tom McCarthy considers his relationship to the novel and its history as a form, including the changing conditions of the contemporary literary world that have allowed for his existence within it. He provides a schematic for understanding the various modes of his own work and his interfacing with a set of “displacements” running through and around various “vanguards.” Along the way, he discusses dead media, money, sound, post-Snowden politics as a literary problem, and the financial utility of Finnegans Wake.
The Microeconomic Mode: Survival Games, Life-Interest, and the Reimagination of Sovereignty
Authors: Elliott Jane 
Published: September 2018

Abstract
This essay examines the relationship between dominant trends in contemporary popular aesthetics and the microeconomic imagination of human behavior, which centers on individual allocation of finite resources to self-determined ends. I argue that this way of modeling human action is embodied and interrogated in what I call the microeconomic mode, a ubiquitous twenty-first-century cultural formation defined by a combination of abstraction and extremity. From Cormac McCarthy's The Road to the Hunger Games franchise, this mode represents individuals making life-and-death choices in radically minimal and/or highly codified settings. I focus here on the most prevalent cultural form in the microeconomic mode, the survival game, as manifested in Gillian Flynn's bestselling novel Gone Girl (2013). By examining the novel's use of the survival game as a response to the gamification of life in twenty-first-century capital, I unpack the role that individual interest in self-preservation plays in constituting contemporary political subjectivity. I read this dynamic in relation to the account of the subject of interest offered by Michel Foucault and argue that what I call life-interest should be understood as an emergent form of biopolitical organization, one in which sovereign power operates by compelling individual agential choices in relation to the preservation of life. In conclusion, I turn to the popular “ticking-time-bomb” torture scenario in order to elucidate something of the permeation and power of life-interest in defining the contemporary imagination of sovereignty, domination, and agency.
“The Freedom to See”: Social Relations and Aesthetic Form in The Golden Bowl
Authors: Stasi Paul 
Published: September 2018

Abstract
This article takes up The Golden Bowl in relation to neoliberalism, considered less as a distinct phase of capitalist accumulation than as an intensification of its long-standing internal tendencies. Taking place, as Edith Wharton put it, “in the void,” James's novel stages a seemingly autonomous and self-sustaining pattern of affective engagements that he, nevertheless, demonstrates are supported by a set of economic relations to which his form consistently, but obliquely, gestures. While the Ververs work to turn economics into affect, James uses aesthetic form to force our affective response to the text back onto structure. In this way, James recovers history as a decidedly human project, precisely the understanding of history effaced by neoliberalism's subservience to the logic of capitalist exchange.
Living afterwards: Vietnamese refugee writers Thuy Le and Viet Nguyen
Authors: Tate Trudi 
Published: September 2018

Abstract
This article explores the writing of Vietnamese-American refugee writers Thuy Le and Viet Nguyen. How do their works reflect upon war trauma and loss of home, and on the lives people live afterwards? The article looks at how families share traumatic memories (or not), and at belated understanding of experience.
Iconoclast Artists: Poems from young Texan poets
Authors: Harris Torrina 
Published: September 2018

Abstract
Iconoclast Artists is a non-profit poetry and performance arts programme founded in Houston, Texas in 2014 by Marlon Lizama and Matthew Russell, and expanded this year to include Galveston. The programme is a growing community of young artists that provides unique support and encouragement for hundreds of underserved students within high schools, middle schools and Juvenile Detention centres. With classroom instruction in creative writing and expression, Iconoclast meets with classes every week to provide academic, artistic and social/emotional support.
A place to call home: Journeys of Eliza Fenwick (1766–1840)
Authors: Paul Lissa 
Published: September 2018

Abstract
In tracing the colonial odyssey of Eliza Fenwick (1766–1840) from Great Britain to Upper Canada, I show her as an immigration success. From her literary life in London as the author of Secresy (1795) and several innovative children’s books, she transformed herself, as a single working mother, and later grandmother, into a school owner, a businesswoman. At the heart of my essay is her search for social and financial security, a place to call home. Her extant – mostly unpublished – letters demonstrate that it was in the welcoming space of Upper Canada that she established a future for her descendants. Lissa Paul’s biography of Eliza Fenwick, Eliza Fenwick (1766–1840): A Life Rewritten, will be published by the University of Delaware Press in their Early Modern Feminisms Series, in early 2019.
In conversation: Alejandro Postigo and Naz Yeni
Authors: Postigo Alejandro , Yeni Naz 
Published: September 2018

Abstract
In April 2018, 7 Husbands for Hurmuz (7 Kocalı Hürmüz), a popular musical comedy farce from Turkey, was staged by Arcola Alaturka, a Turkish-speaking theatre group based in East London. This production was performed by migrant actors and musicians with a predominantly migrant audience in mind. A production of 7 Kocalı Hürmüz was included in the Ankara State Theatre’s 2017–18 season, and another large scale production directed and produced by established comedian Müjdat Gezen has, at the time of writing, been selling out in Istanbul.
Set in a time when a man was permitted more than one wife, the plot of 7 Husbands for Hurmuz is a reversal of this situation: the central character is a woman (Hurmuz) who has married six husbands – none of whom knows about the others – as a way of solving her money problems. She sees each husband on a different day of the week, but mayhem ensues when Hurmuz falls in love with a seventh man, and then all seven turn up to see her on the same day. Farce, slapstick and absurdity combine in a satire, which is also an extension of folk theatre forms relating to specific Asian performance styles – drawing on both ortaoyunu and meddah traditions in Turkey. It can be argued that 7 Husbands for Hurmuz has caused controversy because although the play features an array of strong female characters, it has been perceived as both feminist and anti-feminist.
The following piece is a conversation between Naz Yeni, the director of the Arcola production, and Alejandro Postigo, author and performer of The Copla Musical, a tribute to the anti-Franco Spanish drag artist La Gitana. The Copla Musical explores an intercultural adaptation of the early twentieth-century Spanish folkloric song-form of copla, merged with elements found in Anglo-American musical theatre structures such as book musicals, revues and jukebox shows. Copla ceased to develop during Franco’s regime (1939–1975). Forty years later, The Copla Musical aims to rejuvenate copla interculturally. The show is supported by academic research that questions how to share the Spanish experience of copla with an international audience of diverse cultural backgrounds, and how to introduce copla’s background as a storytelling form, a folkloric genre and a subversive tool beyond the Spanish twentieth-century zeitgeist. The conversation explores the many challenges of translating songs and theatre works from one language to another for a multicultural and multilingual audience.
Rancangan Desain Produk Setrika Pegas Menggunakan Metode Kano
Authors: Nurjannah Anisa , Purnomo Hari 
Published: September 2018

Pengembangan fitur-fitur setrika listrik terus dilakukan guna meningkatkan kepuasan konsumen. Penelitian ini bertujuan untuk mendesain produk setrika listrik berdasar fitur-fitur yang sesuai dengan keinginan dan kepuasan penggunanya. Fitur-fitur yang diinginkan diketahui dari wawancara dan menjadi dasar perbaikan desain setrika listrik yang telah beredar di pasaran. Output dari tahapan Voice of Customers ini kemudian dianalisa untuk dicari tingkat kepentingan tiap fitur menggunakan Metode Kano. Hasil pengolahan dengan Metode Kano menunjukkan enam fitur, dengan kategori tingkat kepuasan berupa attractive dan one-dimentional, yang sangat perlu untuk dikembangkan. Fitur-fitur tersebut adalah: aman, gagang nyaman dipegang, tahan lama, ringan, kesesuaian warna, serta hemat listrik.