bluuebunny/crossref_metadata_2025_split huggingface dataset:
Convergent Metabotropic Signaling Pathways Inhibit SK Channels to Promote Synaptic Plasticity in the Hippocampus
Authors: Tigaret Cezar M. , Chamberlain Sophie E.L. , Sadowski Joseph H.L.P. , Hall Jeremy , Ashby Michael C. , Mellor Jack R. 
Published: September 2018

Hebbian synaptic plasticity at hippocampal Schaffer collateral synapses is tightly regulated by postsynaptic small conductance (SK) channels that restrict NMDA receptor activity. SK channels are themselves modulated by G-protein-coupled signaling pathways, but it is not clear under what conditions these are activated to enable synaptic plasticity. Here, we show that muscarinic M1 receptor (M1R) and type 1 metabotropic glutamate receptor (mGluR1) signaling pathways, which are known to inhibit SK channels and thereby disinhibit NMDA receptors, converge to facilitate spine calcium transients during the induction of long-term potentiation (LTP) at hippocampal Schaffer collateral synapses onto CA1 pyramidal neurons of male rats. Furthermore, mGluR1 activation is required for LTP induced by reactivated place-cell firing patterns that occur in sharp-wave ripple events during rest or sleep. In contrast, M1R activation is required for LTP induced by place-cell firing patterns during exploration. Thus, we describe a common mechanism that enables synaptic plasticity during both encoding and consolidation of memories within hippocampal circuits.SIGNIFICANCE STATEMENTMemory ensembles in the hippocampus are formed during active exploration and consolidated during rest or sleep. These two distinct phases each require strengthening of synaptic connections by long-term potentiation (LTP). The neuronal activity patterns in each phase are very different, which makes it hard to map generalized rules for LTP induction onto both formation and consolidation phases. In this study, we show that inhibition of postsynaptic SK channels is a common necessary feature of LTP induction and that SK channel inhibition is achieved by separate but convergent metabotropic signaling pathways. Thus, we reveal a common mechanism for enabling LTP under distinct behavioral conditions.
A combined computational and experimental study of the adsorption of sulfur containing molecules on molybdenum disulfide nanoparticles
Authors: Yang Tao , Feng Junpeng , Liu Xingchen , Wang Yandan , Ge Hui , Cao Dongbo , Li Hao , Peng Qing , Ramos Manuel , Wen Xiao-Dong , Shen Baojian 
Published: September 2018

Abstract
ANALISIS KORELASI KANONIKAL PADA KOMPONEN DUA SISI NERACA PERUSAHAAN PERBANKAN GO PUBLIK DI INDONESIA (Periode 2005-2011)
Authors: Sukaesih Tien 
Published: September 2018

Penggunaan statistik sudah sering dijumpai pada hasil-hasil penelitian bidang eksakta maupun sosial, hal tersebut diantaranya diuraikan pada artikel-artikel hasil penelitian berbagai jurnal, baik pada penelitian yang berorientasi ingin mendeskripsikan masalah atau variabel penelitian, untuk tujuan eksplorasi maupun yang bertujuan untuk pengujian hipotesis penelitian. Kajian ini membahas tentang bagaimana statistika kanonik dapat diterapkan dengan menganalisis tujuan laporan keuangan, karakteristik kualitatif laporan keuangan, unsur-unsur (elemen) laporan keuangan, pengakuan atas unsur-unsur laporan keuangan, pengukuran atas unsur-unsur laporan keuangan; dan konsep modal dan pemeliharaan modal. Hasil kajian ini menunjukkan bahwa 20 neraca bank dengan menggunakan metode statistik analisis kanonikal memberikan kesimpulan bahwa terdapat hubungan yang bermakna di antara kedua sisi neraca. Hal ini terlihat dari hubungan yang kuat dan searah antara komponen piutang dengan hutang, Ekuitas dengan kas dan surat berharga, dan Ekuitas dengan aktiva tak lancar. Hal ini sekaligus membuktikan hipotesis, yang ditunjukkan oleh pola hubungan yang berhasil diidentifikasi di antaranya hubungan searah positif dan negatif atau perubahan proporsional diantara komponen yang berhubungan.
Semi-rigid minimally invasive transpedicular fixation in the treatment of degenerative diseases of the lumbar spine
Authors: Bulatov A. V. , Rzayev D. A. , Klimov V. S. , Evsyukov A. V. 
Published: September 2018

The study objective is to analyze the effectiveness of the use of minimal invasive polyetheretherketone (PEEK) rod systems in the treatment of lumbar spine degenerative diseases.Materials and methods. The minimal invasive semi-rigid stabilization using PEEK rod systems was performed in 24 patients (4 (17 %) male and 20 (83 %) female) patients (mean age 46.3 ± 8.4, ranging from 32 to 63). The average follow-up duration was 15 months. Inclusion criteria: mechanical low back pain, White–Panjabi instability: 5 points, degenerative changes of the disc by C. Pfirrmann scale: II–IV grade. Follow-up at the 6 and 12 months postoperatively.Results. In the postoperative period, the majority of patients had a complete or significant regression of pain (on average, from 6.3 to 1.8 points on the visual analog scale). The Oswestry disability index decreased from 64/66 [64; 68] to 33/34 [32; 36] in 6 months (p <0.001) and 18/17 [16; 18] in 12 months (p <0.001). Before surgery, the height of the operated disk was 0.96 cm, after 1 year decreased to 0.91 cm. Range of rotary motion in the operated segment in all cases did not exceed 6°.Conclusion. The PEEK rod fixation in patients with mechanical low back pain provides good and excellent clinical results on the I. Macnab scale in 83.4 % of cases. Within 12 months, the minimal volume of movements on the operated segment remains, without signs of continued degeneration of adjacent intervertebral discs.
Possible neurosurgical care to patients with central nervous system tuberculosis in a region with high prevalence of HIV infection
Authors: Petrov S. I. , Novitskaya O. N. 
Published: September 2018

The study objective is to indicate conditions of various operative neurosurgical interventions in patients with tuberculosis / HIV co-infection. Materials and methods. Studied microbiological, radiological and histological characteristics in 682 patients treated, 331 deaths and 12 operated patients with central nervous system tuberculosis combined with HIV infection. Produced 15 operations: ventriculoperitoneal shunting on 3 patients, stereotactic biopsy on 7 patients, removal of inflammatory foci with a capsule on 5 patients.Results. The indications for surgery in only 3 of 24 patients with hydrocephalus have all been a positive effect. The probability of detecting the pathogen of encephalitis biopsy is 71.4 %. All the radical operation for removal of the local formations of the сentral nervous system in conjunction with appropriate chemotherapy led to the recovery of patients.Conclusions. When distributive of hydrocephalus in patients with combined pathology of conditions for the ventriculoperitoneal shunting are no reduction of hydrocephalus in the course of conservative treatment, the reduction of pleocytosis of cerebrospinal fluid under the effect of chemotherapy and positive result of the tap test. A biopsy of the brain in HIV infection are shown in order to clarify diagnosis and determine the range of drug susceptibility for the correction of chemotherapy. Conditions for radical removal of tuberculous formations of the brain in HIV infection are: the absence of a tendency to reduce the size of the formations under the influence of chemotherapy, prescribed within the spectrum of drug susceptibility of at least 2 months; the disappearance of the zone of perifocal edema around the lesion in the brain.
Results of primary endovascular treatment compared to endovascular treatment combined with intravenous thrombolysis in patients with stroke
Authors: Semitko S. P. , Analeev A. I. , Klimov V. P. , Аzarov A. V. , Vanyukov A. E. , Dashchenko E. N. , Bolotov P. A. , Seropegin A. D. 
Published: September 2018

The study objective is to investigate immediate angiographic and clinical results of endovascular treatment of ischemic stroke in patients who had contraindications to the appointment of adjuvant thrombolytic therapy (TLT), and patients who underwent combined treatment (TLT + thrombolysis/thrombextraction).Materials and methods. From 2016 to 2018, selective cerebral arteriography was performed in 48 patients with acute stroke within 4.5 hours from the onset of the disease to ascertain the possibility of endovascular treatment. The main indication was occlusion of a large intracranial vessel (internal carotid artery or middle cerebral artery at the level of M1–M2 segments) according to multislice computed tomography. In the absence of contraindications, TLT was prescribed and selective angiography and thrombaspiration/thrombextraction were performed. In 5 (10.4 %) patients with TLT no occlusion of the intracranial vessel was found, it was interpreted as evidence of effectiveness, these patients were excluded from further analysis.Results. The group of combined treatment (TLT + endovascular procedure) included 18 patients, the group of endovascular treatment without TLT – 25. The severity of stroke in patients who were denied TLT was objectively heavier, which led to a statistically worse prognosis than in patients who were assigned TLT. However, after the endovascular procedure (which was more successful according to a number of indirect criteria), the clinical characteristics of both groups were similar. In patients undergoing endovascular intervention without TLT, thrombaspiration often proved to be an effective, rarely used expensive tools to thrombextraction, decreased the number of attempts of thrombextraction using a stent retriever and there were rare cases of embolization of the distal territory.Conclusion. If it is possible to perform endovascular intervention without TLT and without additional time spent on transportation, it can be a method of choice, providing equal or possibly greater efficacy and safety of treatment in comparison with TLT. Further experience and further research is needed to clarify the value of both methods.
Dzungaria corridor for vacuum magnetic levitation transport: lost opportunities or weighted optimism?
Authors: Bogachev Viktor A. , Terentyev Yuri A. , Koledov Victor V. , Bogachev Taras V. 
Published: September 2018

Background: The complex of issues arising when considering possible options for the implementation of Eurasian transcontinental high-speed land transport corridors operating on the basis of vacuum magnetic-levitation technologies is analyzed. The exclusivity of Russia’s geographical position in a substantial part lies in the fact that it is through its territory that China can be directly linked by these corridors to Western Europe and also to North America, the rationale is done.
Aim: Possible routes connecting Beijing and Shanghai with Moscow are analyzed. Transport highways of a truly innovative type will solve the urgent task of geopolitical level - to organize the states located on the Eurasian continent in a qualitatively new civilizational construction. The purpose of the research is as follows: to develop methods of solving the problems of finding optimal variants for the location of high-speed land transport corridors using computer mathematics systems. This should take into account the features of the territory, through which the transport route is planned to be carried out.
Methods: The economic, political, logistical, geographical, technical and technological aspects of these projects are discussed. Optimization methods are used, in particular, the calculus of variations.
Results: After the creation of a sufficiently informative and detailed informal picture, the basics of the corresponding mathematical models are constructed.
Conclusion: The historical area of Dzungaria is considered as the location of the main intermediate terminal for high speed vacuum magnetic levitation transport.
Phytotoxicity of exotic plants on the physiological potential of seeds of native species of caatinga
Authors: Silva Silvana Fraga , Lopes Costa Halina Stéffany , Viana Jesimiel Silva , Oliveira Ferreira Ana Maria , Pereira Diego Sousa , Filho Sebastião Medeiros 
Published: September 2018

The introduction of species is one of the major causes of biodiversity loss. Invasive exotic plants adapt, propagate and dominate, damaging both natural processes and native species. Thus, the objective was to evaluate the allelopathic effect of three exotic species in the caatinga, on the physiological quality of
native forest seeds. Aqueous extracts of leaves of Azadirachta indica, Prosopis juliflora and Cryptostegia madagascariensis were tested to evaluate their effect on the seed germination and seedling vigor of Piptadenia moniliformis, Mimosa tenuiflora and Mimosa caesalpiniaefolia. Seed germination of M. tenuiflora was inhibited
by the aqueous extracts of P. juliflora and A. indica in 100% and 42%, respectively, with a reduced GVI with the extracts of P. juliflora and C. madagascariensis. Regarding AEI, P. juliflora extract had positive effect on P. moniliformis seeds and negative on M. tenuiflora seeds, close to -1. A reduction in height of P. moniliformis was observed when the seedlings were in contact with the extracts of the invasive plants studied. For M. tenuiflora, the extract of P. juliflora prevented the formation of seedlings, and M. caesalpiniaefolia presented higher inhibitory effect with extracts of P. juliflora and A. indica. Therefore, M. tenuiflora showed to be sensitive to P. juliflora phytotoxicity.
Double‐Annual Forage Crop Rotation Controls Nutrient Surpluses in Nitrogen‐Based Organic Fertilization
Authors: Perramon Bernat , Domingo‐Olivé Francesc , Bosch‐Serra Ángela D. , Yagüe María R. , Boixadera Jaume 
Published: September 2018

Core Ideas
In intensive forage systems, 170 kg N ha−1 just from manures limits C sequestration.
Biennial rotations of four crops maximize nutrient recirculation in calf‐rearing farms.
Double‐annual forage crop rotation reduces P surpluses in crop–livestock systems.
The use of organic fertilizers from stock‐raising activity is usually based on the nitrogen (N) criterion. The objective of our research is to evaluate whether this N criterion led to positive or environmentally risky changes, mainly in organic carbon (OC) storage and the availability of the main nutrients. Three biennial rotations of four crops were set up in a 6‐yr time‐frame. The treatments included a control (no N added); two mineral treatments, where 250 kg N ha−1 yr−1 was provided at two different times during the rotation; three cattle manure treatments, which provided 170, 250, and 500 kg N ha−1 yr−1; and four treatments in which the two lowest manure rates were complemented with mineral N (80 and 160 kg N ha−1 yr−1). Over the 6‐yr period, the measured soil OC increases were equivalent to approximately 25, 43, and 35% of the manure OC applied, respectively, following the manure rate increases. Furthermore, equivalences were of −5, 23, and 25% when compared with full mineral fertilization. The positive slope of phosphorus availability was 1.2 mg Olsen‐P kg−1 to 10 kg P ha−1 applied from manures (N/P = 4) when starting from a threshold of 15.9 mg Olsen‐P kg−1. The availability of other nutrients (Mg, Zn, and Na) also increased with increasing manure rates. In a medium‐term experiment, the manure rate of 250 kg N ha−1 yr−1 optimized the nutrient recirculation. In the long term, rotations should be redesigned to control P surpluses, or the amount of N applied from manures should be reduced.
Microbial Water Quality: Monitoring and Modeling
Authors: Pachepsky Y. A. , Allende A. , Boithias L. , Cho K. , Jamieson R. , Hofstra N. , Molina M. 
Published: September 2018

Microbial water quality lies in the nexus of human, animal, and environmental health. Multidisciplinary efforts are under way to understand how microbial water quality can be monitored, predicted, and managed. This special collection of papers in the Journal of Environmental Quality was inspired by the idea of creating a special section containing the panoramic view of advances and challenges in the arena of microbial water quality research. It addresses various facets of health‐related microorganism release, transport, and survival in the environment. The papers analyze the spatiotemporal variability of microbial water quality, selection of predictors of the spatiotemporal variations, the role of bottom sediments and biofilms, correlations between concentrations of indicator and pathogenic organisms and the role for risk assessment techniques, use of molecular markers, subsurface microbial transport as related to microbial water quality, antibiotic resistance, real‐time monitoring and nowcasting, watershed scale modeling, and monitoring design. Both authors and editors represent international experience in the field. The findings underscore the challenges of observing and understanding microbial water quality; they also suggest promising research directions for improving the knowledge base needed to protect and improve our water sources.Core Ideas
Environmental factors are known to control microbial water quality in natural systems.
This collection of papers presents a panoramic view of microbial water quality research.
With this special section, the editors hope to stimulate interdisciplinary efforts in the field.
Пионеры исследований толпы в зарубежной психологии: Сципион Сигеле и Анри Фурниаль
Authors: Gorbatov Dmitry S. , Baychik Anna V. 
Published: September 2018

Introduction. By the end of the 19th century the society had to adapt to new threats—namely, increasing the number and activity of the proletariat masses and spreading socialist and anarchist ideas. Many researchers concentrated their study on characteristics of crowds. Scipio Sighele and Henry Fournial have been pioneers in this field.
Theoretical Basis. The paper describes two concepts which provided a starting point for studying crowds in foreign psychology. The main issues considered by Scipio Sighele and Henry Fournial were as follows: characteristics of the crowd as a social institution, its properties, activization factors, characteristics of leaders, personality changes within crowds, and the problem of criminal liability for mass crimes. The paper presents an innovative view of (a) the origin of excessive generalization of the crowd concept, (b) its uncritical acceptance in defining a number of social organizations, (c) and wrongful attributing characteristics of individual women to the crowd as the subject of mass action.
Results. The revealed tendencies and a clearly distorted perception of crowds among representatives of the anthropological and criminalistic approach determined the critical attitude towards new science of temporary social groups.
Discussion. A distinct trend towards isolated cognitive constructs and almost complete disregard for the study of the past contribute to a distorted understanding of the phenomenon of crowds in modern social psychology of spontaneous groups. The ideas of researchers of the past seem to be a necessary precondition for developing a holistic approach to this problem.
Highlights

Sighele and H. Fournial created the background for scientific understanding of the phenomenon of crowds until the mid 20th century; they considered the characteristics of the crowd as a social institution, its properties, activization factors, characteristics of leaders, personality changes within crowds, the problem of criminal responsibility for mass crimes.
Methodological weaknesses in S. Sighele’s and H. Fournial’s studies included: (a) attributing negative traits of criminal crowds to other crowd types, (b) attributing a reduced intellectual potential to any meeting, and (c) attributing characteristics of women in the crowd to the crowd as the subject of mass action.
The heritage of S. Sighele, H. Fournial, and other researchers of the initial period can help in overcoming excessive individualism and rationalism in modern crowd psychology.
Определение концентрации водорода по фотоэдс МДП структур Pd-оксид-InP
Authors: Гребенщикова Е.А. , Салихов Х.М. , Сидоров В.Г. , Шутаев В.А. , Яковлев Ю.П. 
Published: September 2018

AbstractThe photovoltage of a metal–insulator–semiconductor structure (Pd–anodic oxide–InP) is studied in relation to the hydrogen concentration in the range 0 . 1–100 vol % in a nitrogen–hydrogen gas mixture. It is shown that, under simultaneous exposure of the structure to light and hydrogen, the photovoltage decay rate and the hydrogen concentration are exponentially related to each other: N _H = a exp( bS ). Here, N _H is the hydrogen concentration (vol %) in the nitrogen–hydrogen mixture. S = dU / dt |_ t _= 0 is the rate at which the signal U changes in the initial portion of the photovoltage decay, beginning from the instant at which the structure is brought into contact with the gas mixture. a and b are constants dependent on the thicknesses of the palladium layer and anodic oxide film on InP.
The Relationship between Intradialytic Hypotension and Hospitalized Mesenteric Ischemia
Authors: Seong Eun Young , Zheng Yuanchao , Winkelmayer Wolfgang C. , Montez-Rath Maria E. , Chang Tara I. 
Published: September 2018

Background and objectives
Mesenteric ischemia is a rare but devastating condition caused by insufficient blood supply to meet the demands of intestinal metabolism. In patients with ESKD, it can be difficult to diagnose and has a >70% mortality rate. Patients on hemodialysis have a high prevalence of predisposing conditions for mesenteric ischemia, but the contribution of intradialytic hypotension, a potential modifiable risk factor, has not been well described.

Design, setting, participants, & measurements
We used data from the US Renal Data System to identify 626 patients on hemodialysis with a hospitalized mesenteric ischemia event (cases). We selected 2428 controls in up to a 1:4 ratio matched by age, sex, black race, incident dialysis year, diabetes mellitus, coronary artery disease, and peripheral artery disease. We used six different definitions of intradialytic hypotension on the basis of prior studies, and categorized patients as having had intradialytic hypotension if ≥30% of hemodialysis sessions in the 30 days before the event met the specified definition.

Results
The proportion of patients with intradialytic hypotension varied depending on its definition: from 19% to 92% of cases and 11% to 94% of controls. Cases had a higher adjusted odds (1.82; 95% confidence interval, 1.47 to 2.26) of having had intradialytic hypotension in the preceding 30 days than controls when using nadir-based intradialytic hypotension definitions such as nadir systolic BP <90 mm Hg. To examine a potential dose-response association of intradialytic hypotension with hospitalized mesenteric ischemia, we categorized patients by the proportion of hemodialysis sessions having intradialytic hypotension, defined using the Nadir90 definition (0%, 1%–9%, 10%–29%, 30%–49%, and ≥50%), and found a direct association of proportion of intradialytic hypotension with hospitalized mesenteric ischemia (P-trend<0.001).

Conclusions
Patients with hospitalized mesenteric ischemia had significantly higher odds of having had intradialytic hypotension in the preceding 30 days than controls, as defined by nadir-based definitions.