bluuebunny/crossref_metadata_2025_split huggingface dataset:
Chronic recording and electrochemical performance of Utah microelectrode arrays implanted in rat motor cortex
Authors: Black Bryan J. , Kanneganti Aswini , Joshi-Imre Alexandra , Rihani Rashed , Chakraborty Bitan , Abbott Justin , Pancrazio Joseph J. , Cogan Stuart F. 
Published: July 2018

Multisite implantable electrode arrays serve as a tool to understand cortical network connectivity and plasticity. Furthermore, they enable electrical stimulation to drive plasticity, study motor/sensory mapping, or provide network input for controlling brain-computer interfaces. Neurobehavioral rodent models are prevalent in studies of motor cortex injury and recovery as well as restoration of auditory/visual cues due to their relatively low cost and ease of training. Therefore, it is important to understand the chronic performance of relevant electrode arrays in rodent models. In this report, we evaluate the chronic recording and electrochemical performance of 16-channel Utah electrode arrays, the current state-of-the-art in pre-/clinical cortical recording and stimulation, in rat motor cortex over a period of 6 mo. The single-unit active electrode yield decreased from 52.8 ± 10.0 ( week 1) to 13.4 ± 5.1% ( week 24). Similarly, the total number of single units recorded on all electrodes across all arrays decreased from 106 to 15 over the same time period. Parallel measurements of electrochemical impedance spectra and cathodic charge storage capacity exhibited significant changes in electrochemical characteristics consistent with development of electrolyte leakage pathways over time. Additionally, measurements of maximum cathodal potential excursion indicated that only a relatively small fraction of electrodes (10–35% at 1 and 24 wk postimplantation) were capable of delivering relevant currents (20 µA at 4 nC/ph) without exceeding negative or positive electrochemical potential limits. In total, our findings suggest mainly abiotic failure modes, including mechanical wire breakage as well as degradation of conducting and insulating substrates. NEW & NOTEWORTHY Multisite implantable electrode arrays serve as a tool to record cortical network activity and enable electrical stimulation to drive plasticity or provide network feedback. The use of rodent models in these fields is prevalent. We evaluated chronic recording and electrochemical performance of 16-channel Utah electrode arrays in rat motor cortex over a period of 6 mo. We primarily observed abiotic failure modes suggestive of mechanical wire breakage and/or degradation of insulation.
To look or not to look? Reward, selection history, and oculomotor guidance
Authors: Preciado Daniel , Theeuwes Jan 
Published: July 2018

The current eye-tracking study examined the influence of reward on oculomotor performance, and the extent to which learned stimulus-reward associations interacted with voluntary oculomotor control with a modified paradigm based on the classical antisaccade task. Participants were shown two equally salient stimuli simultaneously: a gray and a colored circle, and they were instructed to make a fast saccade to one of them. During the first phase of the experiment, participants made a fast saccade toward the colored stimulus, and their performance determined a (cash) bonus. During the second, participants made a saccade toward the gray stimulus, with no rewards available. On each trial, one of three colors was presented, each associated with high, low or no reward during the first phase. Results from the first phase showed improved accuracy and shorter saccade latencies on high-reward trials, while those from the second replicated well-known effects typical of the antisaccade task, namely, decreased accuracy and increased latency during phase II, even despite the absence of abrupt asymmetric onsets. Crucially, performance differences between phases revealed longer latencies and less accurate saccades during the second phase for high-reward trials, compared with the low- and no-reward trials. Further analyses indicated that oculomotor capture by reward signals is mainly found for saccades with short latencies, while this automatic capture can be overridden through voluntary control with longer ones. These results highlight the natural flexibility and adaptability of the attentional system, and the role of reward in modulating this plasticity. NEW & NOTEWORTHY Typically, in the antisaccade task, participants need to suppress an automatic orienting reflex toward a suddenly appearing peripheral stimulus. Here, we introduce an alternative antisaccade task without such abrupt onsets. We replicate well-known antisaccade effects (more errors and longer latencies), demonstrating the role of reward in developing selective oculomotor biases. Results highlight how reward and selection history facilitate developing automatic biases from goal-driven behavior, and they suggest that this process responds to individual differences in impulsivity.
Specificity in the interaction of high-voltage-activated Ca2+ channel types with Ca2+-dependent afterhyperpolarizations in magnocellular supraoptic neurons
Authors: Kirchner Matthew K. , Foehring Robert C. , Callaway Joseph , Armstrong William E. 
Published: July 2018

Magnocellular oxytocin (OT) and vasopressin (VP) neurons express an afterhyperpolarization (AHP) following spike trains that attenuates firing rate and contributes to burst patterning. This AHP includes contributions from an apamin-sensitive, medium-duration AHP (mAHP) and from an apamin-insensitive, slow-duration AHP (sAHP). These AHPs are Ca2+ dependent and activated by Ca2+ influx through voltage-gated Ca2+ channels. Across central nervous system neurons that generate Ca2+-dependent AHPs, the Ca2+ channels that couple to the mAHP and sAHP differ greatly, but for magnocellular neurosecretory cells this relationship is unknown. Using simultaneous whole cell recording and Ca2+ imaging, we evaluated the effect of specific high-voltage-activated (HVA) Ca2+ channel blockers on the mAHP and sAHP. Block of all HVA channels via 400 μM Cd2+ inhibited almost the entire AHP. We tested nifedipine, conotoxin GVIA, agatoxin IVA, and SNX-482, specific blockers of L-, N-, P/Q-, and R-type channels, respectively. The N-type channel blocker conotoxin GVIA (1 μM) was the only toxin that inhibited the mAHP in either OT or VP neurons although the effect on VP neurons was weaker by comparison. The sAHP was significantly inhibited by N-type block in OT neurons and by R-type block in VP neurons although neither accounted for the entirety of the sAHP. Thus the mAHP appears to be elicited by Ca2+ from mostly N-type channels in both OT and VP neurons, but the contributions of specific Ca2+ channel types to the sAHP in each cell type are different. Alternative sources to HVA channels may contribute Ca2+ for the sAHP. NEW & NOTEWORTHY Despite the importance of afterhyperpolarization (AHP) mechanisms for regulating firing behavior of oxytocin (OT) and vasopressin (VP) neurons of supraoptic nucleus, which types of high-voltage-activated Ca2+ channels elicit AHPs in these cells was unknown. We found that N-type channels couple to the medium AHP in both cell types. For the slow AHP, N-type channels contribute in OT neurons, whereas R-type contribute in VP neurons. No single Ca2+ channel blocker abolished the entire AHP, suggesting that additional Ca2+ sources are involved.
Force dynamics and synergist muscle activation in stick insects: the effects of using joint torques as mechanical stimuli
Authors: Zill Sasha N. , Dallmann Chris J. , Büschges Ansgar , Chaudhry Sumaiya , Schmitz Josef 
Published: July 2018

Many sensory systems are tuned to specific parameters of behaviors and have effects that are task-specific. We have studied how force feedback contributes to activation of synergist muscles in serially homologous legs of stick insects. Forces were applied using conventional half-sine or ramp and hold functions. We also utilized waveforms of joint torques calculated from experiments in freely walking animals. In all legs, forces applied to either the tarsus (foot) or proximal leg segment (trochanter) activated synergist muscles that generate substrate grip and support, but coupling of the depressor muscle to tarsal forces was weak in the front legs. Activation of trochanteral receptors using ramp and hold functions generated positive feedback to the depressor muscle in all legs when animals were induced to seek substrate grip. However, discharges of the synergist flexor muscle showed adaptation at moderate force levels. In contrast, application of forces using torque waveforms, which do not have a static hold phase, produced sustained discharges in muscle synergies with little adaptation. Firing frequencies reflected the magnitude of ground reaction forces, were graded to changes in force amplitude, and could also be modulated by transient force perturbations added to the waveforms. Comparison of synergist activation by torques and ramp and hold functions revealed a strong influence of force dynamics (dF/d t). These studies support the idea that force receptors can act to tune muscle synergies synchronously to the range of force magnitudes and dynamics that occur in each leg according to their specific use in behavior.NEW & NOTEWORTHY The effects of force receptors (campaniform sensilla) on leg muscles and synergies were characterized in stick insects using both ramp and hold functions and waveforms of joint torques calculated by inverse dynamics. Motor responses were sustained and showed reduced adaptation to the more “natural” and nonlinear torque stimuli. Calculation of the first derivative (dF/d t) of the torque waveforms demonstrated that this difference was correlated with the dynamic sensitivities of the system.
Tyrosine Kinase Inhibitors Increase MCL1 Degradation and in Combination with BCLXL/BCL2 Inhibitors Drive Prostate Cancer Apoptosis
Authors: Arai Seiji , Jonas Oliver , Whitman Matthew A. , Corey Eva , Balk Steven P. , Chen Sen 
Published: July 2018

Abstract
Purpose: Clinically available BH3 mimetic drugs targeting BCLXL and/or BCL2 (navitoclax and venetoclax, respectively) are effective in some hematologic malignancies, but have limited efficacy in solid tumors. This study aimed to identify combination therapies that exploit clinical BH3 mimetics for prostate cancer.
Experimental Design: Prostate cancer cells or xenografts were treated with BH3 mimetics as single agents or in combination with other agents, and effects on MCL1 and apoptosis were assessed. MCL1 was also targeted directly using RNAi, CRISPR, or an MCL1-specific BH3 mimetic, S63845.
Results: We initially found that MCL1 depletion or inhibition markedly sensitized prostate cancer cells to apoptosis mediated by navitoclax, but not venetoclax, in vitro and in vivo, indicating that they are primed to undergo apoptosis and protected by MCL1 and BCLXL. Small-molecule EGFR kinase inhibitors (erlotinib, lapatinib) also dramatically sensitized to navitoclax-mediated apoptosis, and this was associated with markedly increased proteasome-dependent degradation of MCL1. This increased MCL1 degradation appeared to be through a novel mechanism, as it was not dependent upon GSK3β-mediated phosphorylation and subsequent ubiquitylation by the ubiquitin ligases βTRCP and FBW7, or through other previously identified MCL1 ubiquitin ligases or deubiquitinases. Inhibitors targeting additional kinases (cabozantinib and sorafenib) similarly caused GSK3β-independent MCL1 degradation, and in combination with navitoclax drove apoptosis in vitro and in vivo.
Conclusions: These results show that prostate cancer cells are primed to undergo apoptosis and that cotargeting BCLXL and MCL1, directly or indirectly through agents that increase MCL1 degradation, can induce dramatic apoptotic responses. Clin Cancer Res; 24(21); 5458–70. ©2018 AACR.
Gender Differences in Anxiety and Depression before and after Alcohol Detoxification: Anxiety and Depression as Gender-Related Predictors of Relapse
Authors: Oliva Francesco , Nibbio Gabriele , Vizzuso Paola , Jaretti Sodano Alessandro , Ostacoli Luca , Carletto Sara , Picci Rocco Luigi 
Published: July 2018

<b><i>Background/Aims:</i></b> The aim of this prospective study was to estimate gender differences in anxiety, depression, and alcohol use severity among patients with alcohol use disorder (AUD) before and after detoxification program and within 12 months after discharge. <b><i>Methods:</i></b> AUD severity, state and trait anxiety, and depression were assessed in 187 patients entering an inpatient alcohol detoxification program. Follow-up assessments were performed at 6 and 12 months after discharge. A between- and within-subjects analyses explored gender differences. The predictive value of anxiety and depression for alcohol relapse was analyzed by logistic and linear regression in both genders. <b><i>Results:</i></b> Females had higher levels of anxiety and depression than males both at admission and after discharge. Trait anxiety and depression significantly increased 6 months after discharge in males and females respectively. Both state and trait anxiety levels at the 6-month follow-up predicted alcohol relapse at the 12-month follow-up in males. Conversely, in females, depression level at the 6-month follow-up was a predictor of relapse at the 12-month follow-up. <b><i>Conclusions:</i></b> In both genders, the psychopathological dimension that showed the most significant worsening at 6-month follow-up (i.e., anxiety in males and depression in females) was found to be a significant predictor of relapse at the 12-month follow-up.
Temporal Trends in Contemporary Use of Ventricular Assist Devices by Race and Ethnicity
Authors: Breathett Khadijah , Allen Larry A. , Helmkamp Laura , Colborn Kathryn , Daugherty Stacie L. , Blair Irene V. , Jones Jacqueline , Khazanie Prateeti , Mazimba Sula , McEwen Marylyn , Stone Jeff , Calhoun Elizabeth , Sweitzer Nancy K. , Peterson Pamela N. 
Published: July 2018

Background
The proportion of racial/ethnic minorities receiving ventricular assist devices (VADs) has previously been less than expected. It is unclear if trends have changed since the broadening of access to insurance in 2014 and the rapid adoption of VAD technology.

Methods and Results

Using the Interagency Registry of Mechanically Assisted Circulatory Support, we analyzed time trends by race/ethnicity for 10 795 patients (white, 67.4%; African-American, 24.8%; Hispanic, 6.3%; Asian, 1.5%) who had a VAD implanted between 2012 and 2015. Linear models were fit to the annual census-adjusted rate of VAD implantation for each racial/ethnic group, stratified by sex and age group. From 2012 to 2015, African-Americans had an increase in the census-adjusted annual rate of VAD implantation per 100 000 (0.26 [95% confidence interval, 0.17–0.34]) while other ethnic groups exhibited no significant changes (white: 0.06 [−0.03 to 0.14]; Hispanic: 0.04 [−0.05 to 0.12]; Asian: 0.04 [−0.04 to 0.13]). Stratified by sex, rates increased in both African-American men and women (
P
<0.05), but the change in rate was highest among African-American men (men 0.37 [0.28–0.46]; women 0.16 [0.07–0.25]; interaction with sex
P
=0.004). Stratified by age group, rates increased in African-Americans aged 40 to 69 years and Asians aged 50 to 59 years (
P
<0.05). The observed differential change in VAD implantation rate by age group was significant among African-Americans (interaction with age,
P
<0.01) and Asians (interaction with age,
P
=0.02).

Conclusions
From 2012 to 2015, VAD implantation rates increased among African-Americans but not other racial/ethnic groups. The greatest increase in rate was observed among middle-aged African-American men, suggesting a decline in racial disparities. Further investigation is warranted to reduce disparities among women and older racial/ethnic minorities.
Recanalization in Cerebral Venous Thrombosis
Authors: Aguiar de Sousa Diana , Lucas Neto Lia , Canhão Patrícia , Ferro José M. 
Published: July 2018

Background and Purpose—
The role of recanalization of the occluded dural sinus or vein in the outcome of patients with cerebral venous thrombosis (CVT) is not established. We aimed to systematically review, in patients with CVT, (1) the recanalization rate and its association with (2) clinical outcome and (3) CVT recurrence.

Methods—

Systematic search in MEDLINE (Medical Literature Analysis and Retrieval System Online), Cochrane Library, and
clinicaltrials.gov
(inception to September 2017). We considered cohort studies reporting the recanalization rate in adult patients with CVT treated with anticoagulation. Reported rates of venous recanalization at the last follow-up, functional outcome defined using the modified Rankin scale at last follow-up dichotomized for favorable (0–1) and unfavorable (2–6) outcome, and recurrence rate of CVT according to recanalization status were extracted independently by 2 authors. Meta-analyses of proportions were performed using Freeman-Tukey double arcsine transformation. Functional outcomes according to the recanalization status were compared using meta-analysis and ordinal logistic regression. We conducted sensitivity analyses for time to assessment of recanalization and study quality.

Results—

Four hundred sixty-eight studies were identified, and 19 studies were included. (1) We found report of 694 patients with recanalization in the follow-up among 818 cases of CVT. The overall pooled proportion of patients achieving recanalization was 85% (95% confidence interval, 80–89; I
2
=58%). In studies with higher methodological quality, the recanalization rate was 77% (95% confidence interval, 70–82; I
2
=0%). (2) There was a significant increase in the chance of favorable outcome (modified Rankin scale, 0–1) in patients with recanalization with a pooled odds ratio of 3.3 (95% confidence interval, 1.2–8.9; I
2
=32%) in the random effects meta-analysis and a common odds ratio of 3.3 (95% confidence interval, 1.7–6.3) in the ordinal logistic regression. (3) Data on CVT recurrence according to recanalization was scarce.

Conclusions—
The overall rate of recanalization in patients receiving anticoagulation was 85%, but exclusion of severe patients from follow-up imaging is a plausible source of bias. Lack of venous recanalization was associated with worse clinical outcome.
Recognition Dynamics in the Brain under the Free Energy
Principle
Authors: Kim Chang Sub 
Published: July 2018

Abstract
We formulate the computational processes of perception in the framework of the principle of least action by postulating the theoretical action as a time integral of the variational free energy in the neurosciences. The free energy principle is accordingly rephrased, on autopoetic grounds, as follows: all viable organisms attempt to minimize their sensory uncertainty about an unpredictable environment over a temporal horizon. By taking the variation of informational action, we derive neural recognition dynamics (RD), which by construction reduces to the Bayesian filtering of external states from noisy sensory inputs. Consequently, we effectively cast the gradient-descent scheme of minimizing the free energy into Hamiltonian mechanics by addressing only the positions and momenta of the organisms' representations of the causal environment. To demonstrate the utility of our theory, we show how the RD may be implemented in a neuronally based biophysical model at a single-cell level and subsequently in a coarse-grained, hierarchical architecture of the brain. We also present numerical solutions to the RD for a model brain and analyze the perceptual trajectories around attractors in neural state space.
Diagnostic Analysis of Various Observation Impacts in the 3DVAR Assimilation System of Global GRAPES
Authors: Zhang Lihong , Gong Jiandong , Wang Ruichun 
Published: July 2018

AbstractObservation impact studies have received increasing amounts of research attention. The impacts of observations on numerical weather prediction (NWP) are highly dependent on assimilation algorithm, prediction system, and observation source. Therefore, the major NWP centers worldwide have each developed their own diagnostic techniques to assess observation impacts. However, similar diagnostic techniques have not yet been developed in China. In this study, a diagnostic technique was exploited with the randomized perturbation method in the Global/Regional Assimilation and Prediction System (GRAPES) 3DVAR system, and then applied to evaluate observation impacts for various regions of the world. It was found that a reasonable and stable estimation could be obtained when the number of perturbations was greater than 15. Because of differences in observations in the Northern and Southern Hemispheres, refractivity data from GNSS radio occultation (GNSS-RO), satellite radiance, and atmospheric motion vector data had more impact in the Southern Hemisphere than in the Northern Hemisphere. However, radiosonde data, aircraft, and surface data were more important in the Northern Hemisphere. Low-impact observation points were located in data-rich areas, whereas high-impact observation points were located in data-poor areas. In the equatorial region, the contributions of observations to the analysis were smaller than those in the nonequatorial regions because of the lack of proper mass–wind balance relationship. Radiosondes contributed the largest impact in China and its surrounding regions, with contributions of radiosondes and GNSS-RO data exceeding 60% of the total contributions, except for wind speed below 700 hPa.
Elevated serum YKL-40 correlates with clinical characteristics in patients with polymyositis or dermatomyositis
Authors: Gao Ming-Zhu , Wei Yun-Yu , Xu Qiang-Wei , Ji Rong , Han Zhi-Jun , Jiang Ting-Wang 
Published: July 2018

Background Serum YKL-40 has been proved to be a promising biomarker for estimating the disease activity of several autoimmune diseases. However, its utility in polymyositis or dermatomyositis has not been established. The aim of this study was to investigate the utility of YKL-40 in patients with polymyositis/dermatomyositis. Method Patients with definite polymyositis/dermatomyositis who visited the Second People’s Hospital of Wuxi between April 2016 and March 2017 were prospectively enrolled. Eighty-seven healthy individuals were set as a control. Serum YKL-40 of all participants was determined using ELISA. The associations between YKL-40 and clinical characteristics of polymyositis/dermatomyositis were analysed using the Student’s t-test, Mann-Whitney test and receiver operating characteristic curve analysis. Results A total of 99 patients with polymyositis/dermatomyositis were enrolled. The patients with polymyositis/dermatomyositis had significantly higher serum YKL-40 concentration. Patients with interstitial lung disease had significantly higher YKL-40 concentration than those without. Serum YKL-40 was positively correlated with myositis disease activity assessment visual analogue scale, C-reactive protein, erythrocyte sedimentation rate and ferritin. The area under receiver operating characteristic curve of YKL-40 for identifying interstitial lung disease was 0.82. Conclusions Serum YKL-40 is a useful biomarker for estimating disease activity or severity of polymyositis/dermatomyositis.