bluuebunny/crossref_metadata_2025_split huggingface dataset:
Lipoic acid antagonizes paraquat-induced vascular endothelial dysfunction by suppressing mitochondrial reactive oxidative stress
Authors: Pang Li , Deng Ping , Liang Yi-dan , Qian Jing-yu , Wu Li-Chuan , Yang Ling-ling , Yu Zheng-ping , Zhou Zhou 
Published: September 2019

Abstract
Paraquat (PQ) is a widely used herbicide in the agricultural field. The lack of an effective antidote is the significant cause of high mortality in PQ poisoning. Here, we investigate the antagonistic effects of alpha lipoic acid (α-LA), a naturally existing antioxidant, on PQ toxicity in human microvascular endothelial cells (HMEC-1). All the doses of 250, 500 and 1000 μM α-LA significantly inhibited 1000 μM PQ-induced cytotoxicity in HMEC-1 cells. α-LA pretreatment remarkably diminished the damage to cell migration ability, recovered the declined levels of the vasodilator factor nitric oxide (NO), elevated the expression level of endothelial nitric oxide synthases (eNOS), and inhibited the upregulated expression of vasoconstrictor factor endothelin-1 (ET-1). Moreover, α-LA pretreatment inhibited reactive oxygen species (ROS) generation, suppressed the damage to the mitochondrial membrane potential (ΔΨm) and mitigated the inhibition of adenosine triphosphate (ATP) production in HMEC-1 cells. These results suggested that α-LA could alleviate PQ-induced endothelial dysfunction by suppressing oxidative stress. In summary, our present study provides novel insight into the protective effects and pharmacological potential of α-LA against PQ toxicity in microvascular endothelial cells.
Three-dimensional MHD simulation of the 2008 December 12 coronal mass ejection: from the Sun to Interplanetary space
Authors: Zhang Man , Feng Xue Shang , Yang Li Ping 
Published: September 2019

A three-dimensional time-dependent, numerical magnetohydrodynamic simulation is performed to investigate the propagation of a coronal mass ejection that occurred on 12 December 2008. The background solar wind is obtained by using a splitting finite-volume scheme based on a six-component grid system in spherical coordinate, with Parker’s one-dimensional solar wind solution and measured photospheric magnetic fields as the initial values. A spherical plasmoid is superposed on the realistic ambient solar wind to study the 12 December 2008 coronal mass ejection event. The plasmoid is assumed to have a spheromak magnetic structure with a high-density, high-velocity, and high-pressure near the Sun. The dynamical interaction between the coronal mass ejection and the background solar wind flow is then investigated. We compared the model results with observations, and the model provide a relatively satisfactory comparison with the Wind spacecraft observations at 1 AU. We also investigated the numerical results assuming different parameters of the CME, we find that initial magnetic fields in the CME have a larger influence on the solar wind parameters at the Earth.
Alkoholkonsum und Krebsrisiko
Authors: Scherübl Hans 
Published: September 2019

AbstractAlcohol use is one of the most important and potentially modifiable risk factors for cancer in Germany. The more and the longer a person drinks, the higher the risk of cancer. Even modest use of alcohol may increase cancer risk. Statistically, every German drinks more than 100 gram of alcohol per week; this amount is currently considered to be the limit of low-risk use. Alcohol is causally associated with oropharyngeal and larynx cancer, esophageal squamous cell cancer, hepatocellular carcinoma, breast cancer, and colorectal cancer. People with long-term risky alcohol use should be encouraged to join programs of cancer screening. Alcohol cessation appears to be effective in reducing the alcohol-induced, increased cancer risk.
Tinnitracks – Erste Ergebnisse einer Anwenderbefragung
Authors: Löhler Jan , Dobel Christian 
Published: September 2019

Zusammenfassung
Hintergrund Die Behandlung eines chronischen Tinnitus stellt nach wie vor eine große Herausforderung dar. Vor einigen Jahren wurde das „Tailor-made notched music training“ (TMNMT) als neue Methode vorgeschlagen, bei der die Frequenz eines tonalen Tinnitus aus zu hörender individuell zusammengestellter Musik herausgefiltert wird. Mittlerweile gibt es Apps, mit denen die Behandlung durchgeführt wird, z. B. Tinnitracks.
Methoden Im Frühjahr 2018 wurden insgesamt dreimal die damals 457 anwendenden HNO-Ärztinnen und Ärzte hinsichtlich ihres Eindrucks der Wirksamkeit und Verträglichkeit von Tinnitracks per E-Mail befragt. Die Daten wurden zentral erfasst, arcsin transformiert und mit einfaktorieller ANOVA ausgewertet; t-Tests dienten zur weiteren Analyse.
Ergebnisse Insgesamt antworteten 117 (25,6 %) der 457 befragten HNO-Ärzte. Durchschnittlich wurde die Therapie in den teilnehmenden Praxen seit 1,26 Jahren angewendet. Hinsichtlich der untersuchten Punkte gab es signifikante Effekte hinsichtlich der Lautstärke, der Frequenz und der Angenehmheit des Tinnitus, die dadurch zustande kamen, dass weniger oft negative als gleichbleibende bzw. bessere Ergebnisse durch die Therapie berichtet wurden; signifikante Unterschiede zwischen „gleichbleibend“ und „besser“ im Sinne eines positiven Therapieeffektes gab es nicht.
Diskussion Tinnitracks ist eine App-basierte Therapie des Tinnitus mittels TMNMT, deren Wirksamkeit bisher noch nicht an einer größeren Patientenpopulation untersucht wurde. Die hier vorgestellt Anwenderbefragung zeigte, dass die Tinnitracks hinsichtlich der Tinnituslautstärke und dessen Angenehmheit wenigstens keinen schädlichen Einfluss hat. Die Tinnitusfrequenz wurde nicht signifikant beeinflusst. Negative Effekte waren selten und statistisch nicht signifikant. Insgesamt kann somit z. Zt. keine Empfehlung zur Therapie mit Tinnitracks gegeben werden.
Desenvolvimento de biscoitos integrais à base de farinha de alfarroba como uma alternativa para substituição do cacau em pó
Authors: Farias Jaqueline Nogueira , Nascimento Franciely Patrícia Barbosa do , Salvador Angela Alves , Silva Arthur Alves Negrão da , Tamasia Gislene dos Anjos , Rossetti Francini Xavier , Bello Sérgio Ricardo de Brito , Vicentini Mariana Scudeller 
Published: September 2019

ResumoA farinha de alfarroba, fruto da alfarrobeira (Ceratonia siliqua L.), árvore nativa da região do Mediterrâneo, é considerada um produto saudável e de elevado valor nutritivo, podendo substituir o cacau em pó na produção de produtos alimentícios. A partir disso, o objetivo deste estudo foi desenvolver biscoitos integrais à base de farinha de alfarroba como uma alternativa ao uso do cacau em pó, verificando suas propriedades nutricionais, alterações físicas e aceitabilidade. Os biscoitos foram desenvolvidos a partir da receita padrão à base de cacau em pó, sendo elaboradas três formulações com substituição do cacau pela alfarroba nas proporções de 100%, 50% e 25%. Tal substituição promoveu alterações físicas nos produtos, diminuição no teor de proteínas, carboidratos, gorduras totais e aumento nas fibras. Os possíveis consumidores foram capazes de notar diferença significativa no teste de diferença do controle entre a amostra padrão (100% de cacau) e a III (com menor teor de alfarroba), sendo os demais itens imperceptíveis estatisticamente. De acordo com as análises realizadas e o teste sensorial, verificou-se que a substituição do cacau pela alfarroba é viável.
Penetrated Shotgun Pellets: A Case Report
Authors: Kara M. Isa , Polat Hidayet B. , Ay Sinan 
Published: September 2019

ABSTRACTShotgun wounds can result in devastating functional and aesthetic consequences for patients. There is no consensus in terms of removing or retaining foreign bodies such as shotgun pellets. In this report a 54-year-old man who suffered from accidental shotgun wounds on the face approximately 26 years ago is presented. Although most of pellets were still present, there were no symptoms such as poisoning, fistula formation, recurrent infections, or secondary hemorrhage to date except feeling cold in cold days. (Eur J Dent 2008;2:59-62)
Evaluation of Systemic Markers Related To Anemia of Chronic Disease in the Peripheral Blood of Smokers and Non-Smokers with Chronic Periodontitis
Authors: Erdemir Ebru Olgun , Nalcaci Rana , Caglayan Osman 
Published: September 2019

ABSTRACTObjectives: The aim of this study was to investigate the effect of cigarette smoking on clinical parameters and signs anemia of chronic disease in chronic periodontitis patients.Methods: The study base consisted of 88 patients with chronic periodontitis including 45 volunteer current smokers with age range of 30-69 (45.5±8.5) and 43 volunteer non-smokers with age range of 32-61 years (45.8±7.9). The clinical parameters including plaque index (PI), gingival index (GI), bleeding on probing (BOP), probing depth (PD), clinical attachment loss (CAL) were recorded and several red blood cell parameters were determined from peripheral blood samples.Results: In smokers, PI, PD and CAL were significantly higher than non-smokers (P<.05). The number of erythrocytes and the levels of hemoglobin, hematocrit and iron were lower in smokers compared to non-smokers (P<.05).Conclusions: In the present study, it is concluded that cigarette smoking may be effective on the signs of anemia of chronic disease in patients with chronic periodontitis. (Eur J Dent 2008;2:102-109)
A Case of Unusual Anatomy in Second Mandibular Molar with Four Canals
Authors: Maniglia-Ferreira C. , de Almeida-Gomesa Fábio , Sousa Bruno Carvalho de , Lins Carla Cabral dos Santos Acioli , Santos Roberto Alves dos 
Published: September 2019

ABSTRACTSuccess in root canal treatment is achieved after thought cleaning and shaping followed by the
complete obturation of root canal system. Such treatment may be performed in root canal systems
that do not comply with the normal anatomical features described in standard textbooks. This article
describes the conventional root canal treatment on an unusual mandibular second molar with four
root-canals. (Eur J Dent 2008;2:217-219)
Increased Levels of 8-Hydroxydeoxyguanosine and Malondialdehyde and its Relationship with Antioxidant Enzymes in Saliva of Periodontitis Patients
Authors: Canakci Cenk Fatih , Cicek Yasin , Yildirim Abdulkadir , Sezer Ufuk , Canakci Varol 
Published: September 2019

ABSTRACTObjectives: The aim of this study was to evaluate 8-hydroxydeoxyguanosine (8-OHdG) and Malondialdehyde (MDA) levels, and superoxide dismutase (SOD) and glutathione peroxidase (GPx) activities in whole saliva of patients with chronic periodontitis. Moreover, the relationship among the oxidative damage biomarkers, antioxidant enzymes activities and clinical periodontal status were investigated.Methods: Whole saliva samples were collected from 30 patients with chronic periodontitis and 30 periodontally healthy control. To determine the clinical condition of each subject, the plaque index, gingival index, clinical attachment level, and probing depth were measured. The salivary 8-OHdG level was measured using the ELISA method. SOD and GPx activities and MDA levels were determined spectrophotometrically.Results: Higher salivary 8-OHdG and MDA levels (P<.001), and lower salivary SOD and GPx activities (P<.05) were detected in periodontitis patients compared to the healthy controls. Additionally, there were significantnegative correlations between salivary levels of 8-OHdG and both salivary SOD and GPx activities as well as between salivary levels of MDA and both salivary SOD and GPx activities (P<.001).Conclusions: Higher salivary 8-OHdG and MDA levels and lower salivary antioxidant activities seem to reflect increased oxygen radical activity during periodontal inflammation. (Eur J Dent 2009;3:100- 106)
“Opening” The Mesenchymal Stem Cell Tool Box
Authors: Zeidán-Chuliá Fares , Noda Mami 
Published: September 2019

ABSTRACTAdult mesenchymal stem cells (MSCs) are adherent stromal cells able to self-renew and differentiate into a wide variety of cells and tissues. MSCs can be obtained from distinct tissue sources and have turned out to be successfully manipulated in vitro. As adult stem cells, MSCs are less tumorigenic than their embryonic correlatives and posses another unique characteristic which is their almost null immunogenicity. Moreover, these cells seem to be immunosuppressive in vitro. These facts together with others became MSCs a promising subject of study for future approaches in bioengineering and cell-based therapy. On the other hand, new strategies to achieve long-term integration as well as efficient differentiation of these cells at the area of the lesion are still challenging, and the signalling pathways ruling these processes are not completely well characterized. In this review, we are going summarize the general landscape and current status of the MSC tool as well as their wide potential in tissue engineering, from neuronal to tooth replacement. Highlights and pitfalls for further clinical applications will be discussed. (Eur J Dent 2009;3:240-249)
Effects of Airway Problems on Maxillary Growth: A Review
Authors: Gungor Ahmet Yalcin , Turkkahraman Hakan 
Published: September 2019

ABSTRACTThe volume of air passing through the nose and nasopharinx is limited by its shape and diameter. Continuous airflow through the nasal passage during breathing induces a constant stimulus for the lateral growth of maxilla and for lowering of the palatal vault. Maxillary morphological differences exist between patients with airway problems and control groups, identifying a potential etiological role in these patients. The purpose of this article was to review the literature on the interaction between airway problems and expressed maxillary morphology including specific dental and skeletal malocclusions. Statistically significant differences were found between patients with airway problems and control groups, in maxillary skeletal morphology including shorter maxillary length, more proclined maxillary incisors, thicker and longer soft palate, narrower maxillary arch and higher palatal vault. (Eur J Dent 2009;3:250-254)
Organophosphorus chemistry based on elemental phosphorus: advances and horizons
Authors: Gusarova Nina K. , Trofimov Boris A. 
Published: September 2019

The results of studies on the application of elemental phosphorus for the synthesis of important organophosphorus compounds are surveyed and summarized. Currently, this trend represents a synthetically, environmentally and technologically attractive alternative to classical organophosphorus chemistry based on toxic and corrosive phosphorus chlorides. Direct phosphination and phosphinylation of organic compounds with elemental phosphorus (discussed in the first part of the review) basically extend the range of available phosphines, phosphine chalcogenides and phosphinic acids and provides further development of their synthetic potential (discussed in the second part of the review). It is shown that the breakthrough in this area is largely due to the discovery of reactions of elemental phosphorus (white and red) with various electrophiles in superbasic suspensions and emulsions derived from alkali metal hydroxides and to the development of electrochemical, electrocatalytic and catalytic activation of white phosphorus.
The bibliography includes 299 references.
Experimental and theoretical studies of photoinduced reactions in the solid phase of the interstellar medium
Authors: Murga Maria S. , Wiebe Dmitri S. , Vasyunin Anton I. , Varakin Vladimir N. , Stolyarov Andrey V. 
Published: September 2019

The current state of laboratory studies modelling the photoinduced chemical reactions in the solid phase of the interstellar medium is considered. It is shown that multistage processes including physical adsorption of atoms and molecules from the gas phase of the interstellar medium, their drift over the cosmic dust surface, heterogeneous catalysis, photolysis, radiolysis and desorption of the final products and also the photochemical evolution of the dust grains themselves should be adequately included into the astrochemical models of the interstellar medium. The lack of data on the fundamental thermodynamic and kinetic parameters of photoreactions, needed for quantitative description of the physicochemical transformations in the solid phase of the interstellar medium, is noted.
The bibliography includes 206 references.
Progress in the chemistry of nitrogen-, oxygen- and sulfur-containing heterocyclic systems
Authors: Makhova Nina N. , Belen’kii Leonid I. , Gazieva Galina A. , Dalinger Igor L. , Konstantinova Lidia S. , Kuznetsov Vladimir V. , Kravchenko Angelina N. , Krayushkin Mikhail M. , Rakitin Oleg A. , Starosotnikov Alexey M. , Fershtat Leonid L. , Shevelev Svyatoslav A. , Shirinian Valerik Z. , Yarovenko Vladimir N. 
Published: September 2019

The review is devoted to modern trends in the chemistry of nitrogen-, oxygen-and sulfur-containing monocyclic, polynuclear and benzo(hetero)annulated heterocyclic compounds. Methods for the synthesis and chemical reactivity of furazan, furoxan, thiazole, thiadiazole, dithiazole, thiophene, glycoluril, imidazotriazine, diaziridine and other heterocycles are discussed. Characteristic features of reactions depending on the structure of the starting compounds, intermediates and reaction medium (organic solvents, ionic liquids) and mechanistic aspects of the most interesting transformations are considered. Data on the biological activities and prospects for practical applications of the indicated heterocyclic systems are presented.
The bibliography includes 383 references.
Catalysis and regioselectivity in hydrofunctionalization reactions of unsaturated carbon bonds. Part I
Authors: Beletskaya Irina P. , Nájera Carmen , Yus Miguel 
Published: September 2019

The review presents state-of-the-art data on the influence of catalysts (mainly transition metal complexes) on the regioselectivity of a number of reactions. The most important addition reactions to unsaturated bonds are considered, in particular, hydroformylation, hydrosilylation, hydroboration and hydroxy-, alkoxy- and aminocarbonylation, which give predominantly one product. Particular attention is given to reactions with divergent regioselectivity. The reaction conditions, the structures of metal complexes and the ligands involved are indicated and, in some cases, the reaction mechanism is discussed. Examples of industrial processes using homogeneous catalysis are given.The bibliography includes 203 references.Dedicated to the memory of V.V.Markovnikov.
The dynamic socio-cultural interactions in translating musicals’ librettos
Authors: Sorby Stella 
Published: September 2019

AbstractWhen translating musicals’ librettos from one culture to another, what rôles do socio-cultural factors play? How are they negotiated during the development of the target text? Drawing on some of the major concepts from Actor Network Theory, this study looks at an example from the Mandarin Chinese translation ofMamma Mia!which has recently been performed on the Chinese mainland. It investigates how translators respond to the target socio-cultural context during their libretto translation. The findings suggest that, when translatingMamma Mia!into Chinese, translators operate in a dynamic network of multiple perspectives. Their consumer-oriented interactions with the stakeholders, together with socio-cultural factors, play important rôles in creating resonance with the target audience, and thus contribute to musicals’ commercial success in the global arena. This study leads to a view of the translator as a mediator in the network responding to multiple stakeholders and factors to facilitate the development of the target text.
Effects of normothermic microwave irradiation on CD44+/CD24‒ in breast cancer MDA-MB-231 and MCF-7 cell lines
Authors: Asano Mamiko , Tanaka Satoshi , Sakaguchi Minoru 
Published: September 2019

ABSTRACTWe previously reported that MDA-MB-231 and MCF-7 cells, which are breast cancer cell lines and have cancer and cancer-initiating cells (CICs), were killed following normothermic microwave irradiation in which the cellular temperature was maintained at 37°C. In this study, we investigated the percentages of live or dead cells among CD44+/CD24− cells, which were defined as CICs among MDA-MB-231 and MCF-7 cells, and other types of cells in response to microwave irradiation. CD44+/CD24− cells among MDA-MB-231 cells were killed, thereby decreasing the number of cells, whereas the number of live CD44+/CD24− MCF-7 cells was increased following microwave irradiation. Moreover, adhesion, invasion, and migration were decreased in MDA-MB-231 cells, and the activation of matrix metalloproteinase-2 (MMP-2) in MDA-MB-231 cells was increased following microwave irradiation. These decreased cell activities might have been caused by MMP-2 activation and population changes in CD44+/CD24− in MDA-MB-231 cells.Abbreviations: APC: allophecocyanin; CBB: coomassie Brilliant Blue; CD: cluster of differentiation; CICs: cancer-initiating cells; FACS: fluorescence-activated cell sorting; FBS: fetal bovine serum; FITC: fluorescein isothiocyanate; FTDT: finite-difference time domain; HER2: human epidermal growth factor receptor type 2; PI: propidium iodide.
Optimal Design of Airbag Landing System without Rebound
Authors: Zhou X , Zhou S M , Li D K 
Published: September 2019

Abstract
Airbag system has so many advantages including small volume, superior cushioning performance and easy to control that it has been widely used in many fields such as heavy cargo airdrop, soft landing of spacecraft and so on. In this paper, an optimal design method of the airbag is proposed. First, based on the law of thermodynamics and the deformation assumption of airbag, a mathematical model of airbag landing process is established. The results of the model calculation of the cylindrical airbag is preferably consistent with the results of finite element analysis, which shows that the airbag mathematical model is reasonable and accurate. Second, on the basis of this model, the optimal design method of the airbag without rebound is proposed to solve the problem of rebound which will result in uncontrollable attitude and secondary shock in the landing processes. In this method, the evaluation index of airbag cushioning performance is determined, then the key design parameters which have significant impact on airbag cushioning performance are studied, and the optimization model of airbag under constraint with no rebound is subsequently established and solved. Third, by this method, a cylindrical airbag without rebound is obtained. Compared with the non-optimized one, the maximum impact acceleration of the optimized cylindrical airbag is smaller. Consequently, the effectiveness of the proposed optimal design method is verified.
A quad-stable piezoelectric energy harvester for enhancing energy harvesting from rotational motion: Theoretical model and experiments
Authors: Mei Xutao , Zhou Shengxi , Yang Zhichun , Kaizuka Tsutomu , Nakano Kimihiko 
Published: September 2019

Abstract
Recently, different nonlinear energy harvesters were designed to harvest energy from various rotational motions, which aim to provide power to self-powered wireless sensors. In this paper, a quad-stable piezoelectric energy harvester, comprising of a piezoelectric beam and magnets, is designed to enhance energy harvesting efficiency in rotational motion. In addition, a theoretical model is derived to describe the dynamic performance and the output voltage of the harvester. Furthermore, experimental results demonstrate that the presented harvester in rotational motion exhibits a wider working frequency range compared with that of the bi-stable one. Most importantly, for the rotational speed range of 60 - 420 rpm (1 - 7 HZ), the inter-well oscillation for the harvester can be achieved and corresponding peak voltage is higher than 10 V, which can be used to power wireless sensors. Overall, the quad-stable piezoelectric energy harvester is experimentally verified to be suitable for the low-frequency rotational environment.