bluuebunny/crossref_metadata_2025_split huggingface dataset:
Thermoelectrically Activated Chips for Optical Sensing: A portable diagnostic platform for improved immunoassay specificity
Authors: Tiburzi Olivia , Dembner Daniel , Dezsi Geza , Venkatasubramanian Rama , Astatke Mekbib , Gerasopoulos Konstantinos 
Published: October 2019

AbstractImmunological‐based assays have been widely used in diagnostic applications since the initial description of the methodology for the detection of human insulin. However, the development of immunoassays has been hindered by inherent cross‐reactivities between antibodies (Ab) and closely related antigens (Ag) that contribute to false‐positive results. In this work, we utilize temperature‐dependent immunoassay measurements to distinguish between closely related flavivirus antigens—obviating the need for a laborious development effort to ensure assay specificity. A novel platform named Thermoelectrically Activated Chips for Optical Sensing (TACOS), consisting of a miniaturized well plate overlaid on an array of thermoelectric cooling or heating pixels, enables simultaneous immunoassay measurements at different binding temperatures. The efficacy of Ab‐Ag complex formation correlates with the affinity between the Ab‐Ag pair, which is in turn dependent on the binding temperature controlled by the TACOS platform. In this study, Ab‐Ag complex formation over a temperature range is demonstrated as a unique identifier of Ab‐Ag complex composition. We contend that TACOS circumvents the need for extensive and expensive immunoassay developments and therefore enables future diagnostic tests suitable for far‐forward field applications.
The Alternaria Mycotoxin Alternariol Triggers the Immune Response of IL‐1β‐stimulated, Differentiated Caco‐2 Cells
Authors: Schmutz Cornelia , Cenk Ebru , Marko Doris 
Published: October 2019

ScopeAlternariol (AOH), a toxic secondary metabolite of Alternaria spp., may contaminate a broad spectrum of food and feed. Besides its cytotoxic, genotoxic, and estrogenic properties, several studies report the potential of AOH to suppress the rich network of immune responses. The specific effect of AOH on inflammation‐related signaling in non‐immune cells of the intestinal epithelial layer has, however, not been investigated yet. Since intestinal epithelial cells (IECs) are, compared to underlying cells, exposed to higher concentrations of the ingested mycotoxin, the question is addressed whether immunomodulation by AOH at the gastrointestinal barrier must be considered.Methods and resultsThe impact of AOH (0.02–40 µm) on inflammatory signaling in either IL‐1β‐stimulated or non‐stimulated differentiated Caco‐2 cells is determined. AOH significantly reduces IL‐1β transcription after 5 h but shows an increasing tendency on IL‐8 transcript levels after long‐term exposure (20 h). In IL‐1β‐stimulated cells, AOH (20–40 µm) augments TNF‐α transcripts while repressing IL‐8, IL‐6, and IL‐1β transcription as well as IL‐8 secretion. Furthermore, inflammation‐related microRNAs miR‐16, miR‐146a, miR‐125b, and miR‐155 are altered in response to AOH.ConclusionThe obtained data indicate that AOH represses immune responses in an inflamed environment, possibly leading to higher susceptibility to diseases.
Magnetic quadrupole mode excitation of a cylindrical dielectric resonator antenna using planar feed
Authors: Ojha Anuj K. , Jain Rutwik , Kumar AV Praveen 
Published: October 2019

AbstractIn this article, excitation of the magnetic quadrupole mode of a cylindrical dielectric resonator antenna, designated as the HEM21δ mode, using planar feeding technique is discussed for the first time. Two types of planar feeds—a dual‐microstrip feed and a dual‐slot feed are numerically investigated. Results show that the dual‐slot feed is more suitable for exciting the HEM21δ mode as it gives better symmetry of the radiation pattern and lower cross‐polarization level. A DRA prototype (dielectric constant, εr = 24, loss tangent, tanδ = 0.002, diameter, 2a = 19.43 mm and height, h = 7.3 mm) using dual‐slot feed is fabricated and characterized. Measurements demonstrate a resonant frequency of ~ 4.96 GHz, bandwidth of ~4.4%, peak gain of ~3.45 dBi and peak cross‐polar level of ~ − 11 dB for the HEM21δ mode, which are in decent agreement with numerical predictions.
Chemically modified xanthan and gellan for preparation of biomaterials for ophthalmic applications
Authors: Hamcerencu Mihaela , Popa Marcel , Riess Gerard , Desbrieres Jacques 
Published: October 2019

AbstractGellan and xanthan are extracellular polysaccharides with very interesting rheological or gelling properties. They are esterified with acrylic acid, acryloyl chloride or maleic anhydride. Consequently, due to the presence of carbon double bonds, hydrogels are obtained using a grafting–crosslinking process withN‐isopropylacrylamide andN′‐bisacrylamide. Such hydrogels, due to the presence of poly(N‐isopropylacrylamide), are thermosensitive and present drug release properties which can be adjusted through the reaction conditions. This concept was demonstrated for ophthalmic applications. © 2019 Society of Chemical Industry
Fully renewable limonene‐derived polycarbonate as a high‐performance alkyd resin
Authors: Li Chunliang , Veldhuis Theo , Reuvers Bart , Sablong Rafaël J , Koning Cor E 
Published: October 2019

AbstractLimonene‐derived polycarbonate‐based alkyd resins (ARs) have been prepared by copolymerization of limonene dioxide with CO2, catalysed by a β‐diiminate zinc–bis(trimethylsilyl)amido complex, and subsequent chemical modification with soybean oil fatty acids using triphenylethylphosphonium bromide as the catalyst. This quantitative partial modification was realized via epoxy–carboxylic acid chemistry, affording ARs with higher oil lengths, lower polydispersities and higher glass transition temperatures (Tg) in comparison to a conventional polyester AR based on phthalic acid, multifunctional polyol pentaerythritol and soybean fatty acid. The novel limonene polycarbonate AR and the conventional polyester AR were evaluated as coatings and both the physical drying (without the presence of the oxidative drying accelerator Borchi® Oxy Coat) and chemical curing (with Borchi® Oxy Coat) processes of these coatings were monitored by measuring the König hardness and complex modulus development with time. A better performance was obtained for the alkyd paint containing polycarbonates modified with fatty acids (FA‐PCs), which showed a faster chemical drying, a higher König hardness and a higher Tg in coating evaluation, demonstrating that the fully renewable FA‐PCs are promising resins for alkyd paint applications. © 2019 Society of Chemical Industry
Influence of Antagonistic Hamstring Coactivation on Measurement of Quadriceps Strength in Older Adults
Authors: Sisante Jason‐Flor , Wang Na , Felson David T. , Nevitt Michael C. , Lewis Cora E. , Frey‐Law Laura , Segal Neil A. ,   for the Multicenter Osteoarthritis Study (MOST) Group
Published: October 2019

BackgroundThere is limited understanding of how antagonist muscle coactivation relates to measurement of strength in both individuals with and without knee osteoarthritis (KOA).ObjectiveThis study sought to determine whether hamstring coactivation during a maximal quadriceps activation task attenuates net quadriceps strength.DesignCross‐sectional cohort analysis was conducted using data from the 60‐month visit of the Multicenter Osteoarthritis Study (MOST).SettingLaboratory.ParticipantsA sample of 2328 community‐dwelling MOST participants between the ages of 55 and 84 years, with or at elevated risk for KOA, completed the 60‐month MOST follow‐up visit. Of these, 1666 met inclusion criteria for the current study.InterventionsNot applicable.Main Outcome Measure(s)Quadriceps strength; percentage of combined hamstring coactivation (HC), medial HC, and lateral HC. Quadriceps and hamstring strength were assessed using an isokinetic dynamometer. Surface electromyography was used to assess muscle activation patterns. General linear models, adjusted for age, BMI, Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), Kellgren‐Lawrence (KL) grade and study site, modeled the relationship between antagonist hamstring coactivation and quadriceps strength.ResultsMen had significantly greater quadriceps strength (P < .001), history of knee injury (P < .001) and surgery (P = .002), and greater presence of varus malalignment (P < .001). Women had greater pain (P < .001) and proportion of KL grade ≥2 (P = .017). Gender‐specific analyses revealed combined HC (P = .013) and lateral HC inversely associated with quadriceps strength in women (P = .023) but not in men (combined HC P = .320, lateral HC P = .755). A nonlinear association was detected between quadriceps strength and medial HC. Assessment of quartiles of medial HC revealed the third quartile had reduced quadriceps strength when compared to the lowest quartile of coactivation in both men and women.ConclusionsHamstring coactivation attenuates measured quadriceps strength in women with or at elevated risk for KOA.Level of EvidenceII.
Method Comparison for Detection and Measurement of Rotator Cuff Tears: Office‐based Bedside Ultrasonography by a Single Physiatrist versus Imaging Center–based Ultrasonography by Two Expert Musculoskeletal Radiologists
Authors: Tang Chi‐Tsai , Decker Gregory , Steger‐May Karen , Middleton William , Teefey Sharlene 
Published: October 2019

IntroductionThere is increasing interest among physiatrists in using bedside ultrasonography to assess rotator cuff tears.ObjectiveTo conduct a method comparison between ultrasonography performed by a single physiatrist at bedside and two validated expert musculoskeletal radiologists at an imaging center.DesignProspective, blinded comparison study.SettingAcademic outpatient clinic and imaging center.PatientsSeventy‐two unilateral shoulders were scanned. Inclusion criteria included pain or weakness with rotator cuff testing and compliance with repeat ultrasonography.InterventionsUltrasonography performed by the physiatrist was done at bedside during the patient's clinical visit, while the radiologists' scan was performed afterwards in an imaging center. The radiologists trained the physiatrist who was performing the scans.Main Outcome MeasurementsThe primary outcome was integrity of the rotator cuff (intact, partial tear, full tear). When a posterior cuff (supraspinatus, infraspinatus, teres minor) tear was detected, measurements of length, width, and distance from the biceps tendon were taken.ResultsWith use of the radiologists' scan as a criterion standard, bedside ultrasonography performed by the physiatrist for detection of posterior cuff tears had a percent perfect agreement of 72.2% for categorization as no tear, partial tear, or full tear. When evaluating dichotomously for presence of a full tear, sensitivity was 82.1% and specificity was 93.9%. Seven (18%) full‐thickness tears were missed, and all were essentially small (<15 mm). When physiatrist and radiologist measurements were compared, the mean ± standard deviation (SD) difference in length was 3.4 ± 4.7 mm, width was 2.7 ± 6.7 mm, and distance to the biceps tendon was −0.8 ± 7.5 mm.ConclusionsOffice‐based bedside ultrasonography is a reasonable modality to rule out medium/large full‐thickness posterior cuff tears. However, physicians should be aware that a percentage of small full‐thickness tears can be missed. Further imaging should be considered in suspected partial tears and full tears that may be appropriate for surgical repair.
Structural insights into Acyl‐coenzyme A binding domain containing 3 (ACBD3) protein hijacking by picornaviruses
Authors: Chalupska Dominika , Różycki Bartosz , Klima Martin , Boura Evzen 
Published: October 2019

AbstractMany picornaviruses hijack the Golgi resident Acyl‐coenzyme A binding domain containing 3 (ACBD3) protein in order to recruit the phosphatidylinositol 4‐kinase B (PI4KB) to viral replication organelles (ROs). PI4KB, once recruited and activated by ACBD3 protein, produces the lipid phosphatidylinositol 4‐phosphate (PI4P), which is a key step in the biogenesis of viral ROs. To do so, picornaviruses use their small nonstructural protein 3A that binds the Golgi dynamics domain of the ACBD3 protein. Here, we present the analysis of the highly flexible ACBD3 proteins and the viral 3A protein in solution using small‐angle X‐ray scattering and computer simulations. Our analysis revealed that both the ACBD3 protein and the 3A:ACBD3 protein complex have an extended and flexible conformation in solution.
Nasdaq ex‐day behavior: An out‐of‐sample test
Authors: Paudel Shishir , Silveri Sabatino (Dino) , Wu Mark 
Published: October 2019

AbstractWe test various explanations of the ex‐dividend day price anomaly using Nasdaq‐listed firms. Similar to NYSE‐listed firms, on average the prices of Nasdaq‐listed firms drop by less than the dividend amount. However, the average Nasdaq price‐drop is substantially smaller than what existing theories would predict and translates to an imputed dividend tax rate that is double the maximum tax rate. We thus find little support for the tax hypothesis. We also find little support for the short‐term trading hypothesis and various other explanations. The significant disconnect we document between Nasdaq dividends and price changes seems to support the “free dividends fallacy.”
Stability and control of uncertain ICPT system considering time‐varying delay and stochastic disturbance
Authors: Yu Zhongming , Sun Yue , Dai Xin , Ye Zhaohong 
Published: October 2019

SummaryThis paper studies the problem of robust exponential stability for uncertain inductively coupled power transfer (ICPT) system considering time‐varying delay and stochastic disturbance. Firstly, the model of the system is set up via a time domain method. Secondly, based on the Newton‐Leibnitz formula and stability theory, a new stability analysis of the ICPT system with uncertain parameter and time‐varying delay or stochastic disturbance is presented respectively. The proposed approach can be applied for analyzing other similar systems, and the obtained results can be also used for estimating convergence rate and region of stability. Thirdly, based on the Lyapunov‐Krasovskii functional (LKF) approach and the stochastic stability theory, robust exponential stability criteria in the mean square are derived and the relevant controller is designed. The proposed method can further reduce conservatism. Finally, the correctness and effectiveness of the obtained results are verified by an example and simulations indicate that the larger time delay, the slower attenuation. Simultaneously, the uncertain parameter and the stochastic disturbance have a significant influence on the region of stability. In addition, in respect of reducing conservatism, the effectiveness of the proposed method is demonstrated by comparing with other papers. In addition, the designed controller shows better performance for the ICPT system with the parameter uncertainty, the time‐varying delay, and the stochastic disturbance.
35.1: Invited Paper: Measurement and Standardization of Display Lighting Units
Authors: Wang Jianping , Kalantar Kalil 
Published: October 2019

Display lighting unit has always been the focus for optimization when comes into display engineering to improve its electrical, optical, and electro‐optical performance. In recent years, with the development of reflective LCD (liquid crystal display), electronic paper display, laser projection display, etc., the measurement of display lighting unit has received more attention. The IEC TC110 "Electronic Display" established the standardization team PT62595 to develop international standards. Currently, the project team has worked a variety of lighting technologies, including back light unit (BLU) and front light unit (FLU), light module and engine, light bar, and light components. In this paper, we reviewed the roadmap of this group and key items that involve in the measurement methods to give an overview of the documents.In the previous year, the IEC released two new standards, IEC62595‐2‐2 “Measuring methods of LED light bars used in LCD BLUs” and IEC62595‐2‐3 “Electro‐optical measuring methods of LED frontlight unit”. Both documents have now been put into the implementation in the display industry.In IEC 6595‐2‐2, spatial luminance uniformity and angular luminance, color uniformity and color angular uniformity were addressed. In Figure 1, it shows an example of a typical light bar luminance distribution profile to indicate the luminance uniformity by quantifying the information along axis.Example of the luminance distribution profiles along the x‐axis, Lv(x, o)figureIn addition, in order to achieve these characteristics, the optical coupling analysis and optimization between the light bar and the light guide plate (LGP) was discussed. Furthermore, this work introduced the specifications on the requirements for test environment, the architecture of the test equipment, the reference diffuser settings, and the coordinate system.In IEC 62595‐2‐3, the standard specifies the measurement conditions and measuring methods for determining electrical, optical, and electro‐optical properties of LED FLUs for reflective displays. In FLU, the light ray of the FLU with a reflective LC display can be sensitive to the testing position and viewing direction. As shown in Figure 2, light rays are introduced to the LGP (light guide plate) from the coupling side. The rays are reflected on the inner surfaces of the micro‐structures (on the front surface) due to TIR (total internal reflection). The FLU is served as a transparent medium that has reflection property on both surfaces. We explained some of the factors that were covered in the standard document for the measurement and evaluation of both surfaces, including angular luminance distribution, luminance uniformity, spectral power distribution, chromaticity uniformity and angular color uniformity in CIE 1976 system, as well as FLU‐polarization characteristics and optical noise (undesired luminance) along the zenith angle in any azimuth angle.Light rays of FLU with a reflective LC displayfigure
P‐3.4: Hybrid computational near‐eye light field display
Authors: Zhao Jian , Xia Jun 
Published: October 2019

We propose a hybrid computational near‐eye light field display based on micro‐lens arrays (MLAs) and structure parameters prioritization method (SPPM) which can render correct accommodation and expand the depth of field (DOF). The proposed display consists two MLAs and two micro‐displays. Two sets of depth‐sliced images are superimposed to reconstruct the object's light field. The system's ray resolution and the spectra difference between the proposed light field and the conventional one are discussed. The DOF of the proposed system is extended without the requiring of high refresh rate display. Furthermore, structure parameters prioritization method is proposed to extend the spatial frequency of the light field. A prototype is demonstrated and the experimental result shows that the depth field of the reconstructed images is significantly increased compared with conventional near‐eye light field display based on single MLA.Schematic of the configuration of the proposed systemfigureThe result of experiment 1: VR modefigureThe result of experiment 2: AR modefigureWe proposed a novel hybrid near‐eye light field display based on MLA to improve the DoF of the reconstructed light field, which is capable of expanding the accommodation range for virtual and augmented reality. The new algorithm for optimizing the structure parameters of hybrid computational neareye light field display is proposed to lessen the ray resolution and the mismatching of the reconstructed light field. We evaluate the capability of extending DOF through optical experiment. It shows that the propose system can effectively expand the depth range in near‐eye displays.
P‐13.11: A Color Gamut Mapping Reducing the Influence of IR‐drop in OLED Displays
Authors: Ouyang Junting , Lyu Bojia , Peng DZ , Yang Kang , Kong Xiangzi , Xiong Zhiyong , Yang Yang 
Published: October 2019

In this paper, a method of reducing the influence of IR‐drop in OLED display for color gamut mapping (CGM) is described. Due to the IR‐drop, the parameters can be hardly calculated only by formulas, which make the inaccuracy of CGM.This algorithm uses the IR‐drop data of specific gray scale data to find out the IR‐drop rule of arbitrary gray scale. The method is easy and accurate to reduce the influence of IR‐drop, making the CGM better applied to OLED displays.
Ga‐Based Liquid Metal Micro/Nanoparticles: Recent Advances and Applications
Authors: Song Hyunsun , Kim Taekyung , Kang Seohyun , Jin Haneul , Lee Kwangyeol , Yoon Hyo Jae 
Published: October 2019

AbstractLiquid metals are emerging as fluidic inorganic materials in various research fields. Micro‐ and nanoparticles of Ga and its alloys have received particular attention in the last decade due to their non toxicity and accessibility in ambient conditions as well as their interesting chemical, physical, mechanical, and electrical properties. Unique features such as a fluidic nature and self‐passivating oxide skin make Ga‐based liquid metal particles (LMPs) distinguishable from conventional inorganic particles in the context of synthesis and applications. Here, recent advances in the bottom‐up and top‐down synthetic methods of Ga‐based LMPs, their physicochemical properties, and their applications are summarized. Finally, the current status of the LMPs is highlighted and perspectives on future directions are also provided.
Circulating metabolites and the risk of type 2 diabetes: a prospective study of 11,896 young adults from four Finnish cohorts
Authors: Ahola-Olli Ari V. , Mustelin Linda , Kalimeri Maria , Kettunen Johannes , Jokelainen Jari , Auvinen Juha , Puukka Katri , Havulinna Aki S. , Lehtimäki Terho , Kähönen Mika , Juonala Markus , Keinänen-Kiukaanniemi Sirkka , Salomaa Veikko , Perola Markus , Järvelin Marjo-Riitta , Ala-Korpela Mika , Raitakari Olli , Würtz Peter 
Published: October 2019

Abstract

Aims/hypothesis
Metabolomics technologies have identified numerous blood biomarkers for type 2 diabetes risk in case−control studies of middle-aged and older individuals. We aimed to validate existing and identify novel metabolic biomarkers predictive of future diabetes in large cohorts of young adults.

Methods
NMR metabolomics was used to quantify 229 circulating metabolic measures in 11,896 individuals from four Finnish observational cohorts (baseline age 24–45 years). Associations between baseline metabolites and risk of developing diabetes during 8–15 years of follow-up (392 incident cases) were adjusted for sex, age, BMI and fasting glucose. Prospective metabolite associations were also tested with fasting glucose, 2 h glucose and HOMA-IR at follow-up.

Results
Out of 229 metabolic measures, 113 were associated with incident type 2 diabetes in meta-analysis of the four cohorts (ORs per 1 SD: 0.59–1.50; p< 0.0009). Among the strongest biomarkers of diabetes risk were branched-chain and aromatic amino acids (OR 1.31–1.33) and triacylglycerol within VLDL particles (OR 1.33–1.50), as well as linoleic n-6 fatty acid (OR 0.75) and non-esterified cholesterol in large HDL particles (OR 0.59). The metabolic biomarkers were more strongly associated with deterioration in post-load glucose and insulin resistance than with future fasting hyperglycaemia. A multi-metabolite score comprised of phenylalanine, non-esterified cholesterol in large HDL and the ratio of cholesteryl ester to total lipid in large VLDL was associated with future diabetes risk (OR 10.1 comparing individuals in upper vs lower fifth of the multi-metabolite score) in one of the cohorts (mean age 31 years).

Conclusions/interpretation
Metabolic biomarkers across multiple molecular pathways are already predictive of the long-term risk of diabetes in young adults. Comprehensive metabolic profiling may help to target preventive interventions for young asymptomatic individuals at increased risk.