bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Novel Platform for Cancer Vaccines: Antigen-Selective Delivery to Splenic Marginal Zone B Cells via Repeated Injections of PEGylated Liposomes
Authors: Shimizu Taro , Abu Lila Amr S. , Kawaguchi Yoshino , Shimazaki Yuna , Watanabe Yuki , Mima Yu , Hashimoto Yosuke , Okuhira Keiichiro , Storm Gert , Ishima Yu , Ishida Tatsuhiro 
Published: October 2018

Abstract
Treating cancer with vaccines has been a challenge. In this study, we introduce a novel Ag delivery platform for cancer vaccines that delivers an encapsulated Ag to splenic marginal zone B (MZ-B) cells via the aid of a PEGylated liposome (PL) system. Splenic MZ-B cells have recently attracted interest as alternative APCs. In mice, preimmunization with empty (no Ag encapsulation) PLs triggered the efficient delivery of a subsequent dose of Ag-containing PLs, injected 3 d later, to the spleen compared with a single dose of Ag-containing PLs. In addition, immunization with empty PLs allowed three subsequent sequential injections of OVA-PLs to efficiently induce a CTL response against OVA-expressing murine thymoma (EG7-OVA) cells and resulted in in vivo growth inhibition of subsequently inoculated EG7-OVA cells. However, these sequential treatments require repeated immunizations to achieve their antitumor effect. Therefore, to improve the antitumor effect of our novel vaccine system, an adjuvant, α-galactosylceramide (αGC), was incorporated into the OVA-PLs (αGC/OVA-PLs). As expected, the incorporation of αGC reduced the required number of immunizations with OVA-PLs to the point that a single immunization treatment with empty PLs and an injection of αGC/OVA-PL efficiently triggered a potent CTL induction, resulting in a rejection of the development and a suppression of the growth of tumors that had already developed s.c. Results of this study indicate that a novel Ag delivery platform that grants efficient Ag delivery to splenic MZ-B cells shows promise as a therapeutic modality for conquering tumor growth and/or progression.
Retracted: Comparative Effectuality of Two Pre-Procedural Mouthwashes during Debonding - A Clinical Study
Authors: Arshad Faisal , Kumar H. C. Shashi , Swamy G. S. Kartik , Lokesh N. K. , Begum Shamshad 
Published: October 2018

At the request of the Editor-in-Chief and Editorial Board of the journal, the following article has been retracted: Arshad F, Kumar HCS, Swamy GSK, Lokesh NK, Begum S. Comparative effectuality of two pre-procedural mouthwashes during debonding – A clinical study. J Indian Orthod Soc. 2018;52:248-254. DOI: 10.4103/jios.jios_245_17.
Rare Case of Sellar and Suprasellar Metastasis from Ewing’s Sarcoma of Tibia
Authors: Gupta Vinita , Aggarwal Kirti , Nishant Prateek , Arora Rajnish Kumar 
Published: October 2018

ABSTRACTWe hereby report a case of metastatic Ewing’s sarcoma presenting with rapid-onset total ophthalmoplegia, optic atrophy, and right temporal hemianopia. Comprehensive ophthalmic and neurological evaluation with targeted radioimaging revealed a tumor mass centered over the sella, compressing optic chiasma, extending to involve the left cavernous sinus and the left orbital apex. Whole-body imaging revealed the evidence of multifocal lung and mediastinal metastasis with focal lytic defect in the left femoral head. Histopathological evaluation of transnasal punch biopsy from the nasopharyngeal extension of the tumor revealed small round-cell tumor with strong CD99 positivity, supporting the diagnosis of Ewing’s sarcoma. Rapid, aggressive extensions of the metastatic tumor into vital structures despite the initiation of chemoradiation of the extensive intracranial tumor led to unexpected demise of the patient. Our case is an unusual case of Ewing’s sarcoma metastasis manifesting as a sellar mass and mimicking a pituitary adenoma radiologically, with a rapid progression within 2 weeks to cause massive extension of tumor into suprasellar, infrasellar, and left parasellar area, indicative of highly malignant nature of the tumor.
Serum Interleukin-6 is Not Linked with Sleep-Quality, Restless Legs Syndrome, and Depression, But with 6-Month Survival in Hematological Malignancies
Authors: Chandra Smita , Gupta Vibha , Chandra Harish , Dhyani Mohan , Kotwal Aarti , Verma Sanjiv Kumar , Gupta Ravi 
Published: October 2018

ABSTRACT
Background: Serum interleukin (IL)-6 has been found to be associated with sleep quality, mood, and survival in patients with solid tumors. Results in these studies were confounded by knowledge of diagnosis to study subjects. Moreover, such data among subjects with hematological malignancies and data regarding restless legs syndrome is limited. The present study was, therefore, conducted to assess the sleep quality, depression, and restless leg syndrome in hematological malignancies and to study if there is any role of IL6 associated with it. Methods: Sixty-six subjects having hematological malignancy were included in this study after excluding the potential confounders. Sleep quality was examined using Pittsburg Sleep Quality Index, depression by the Patient Health Questionnaire-9. Diagnosis of RLS was made through clinical examination. Serum for measurement of IL-6 was collected at baseline and after 1 month of initiation of chemotherapy. Patients were followed up for 6 months. Results: Average age of study subjects was 50.16 years with male predominance. Nearly 22.7% had clinical depression, 28.8% had poor quality sleep, and restless legs syndrome (RLS) was reported in 6.1% cases. Nearly 22.7% patients died at 6 months. Disturbed sleep at baseline was associated with depression (odds ratio [OR] =7.89) and poor 6 months survival. Serum IL-6 did not show any association with sleep quality, restless-legs-syndrome, and depression. However, baseline high level of serum IL-6 (OR = 26.06) and low level after chemotherapy (OR = 0.03) were associated with poor survival at 6 months. Conclusion: Poor quality sleep, depression, and RLS are prevalent among adult subjects with hematological malignancies. Sleep disturbance, high pretreatment inflammatory and lowering of inflammatory load after chemotherapy increase likelihood for poor prognosis. Serum IL-6 did not show any association with sleep quality, restless legs syndrome and depression.
Surgical Experience in Pediatric Patients with Chiari-I Malformations Aged ≤18 Years
Authors: Singhal Ghanshyam Das , Singhal Shakti , Agrawal Gunjan , Singhal Deepti , Arora Vipin 
Published: October 2018

ABSTRACT
Objective: The objective of this study was to retrospectively study Chiari I malformation patients (<18 years) treated surgically. Materials and Methods: Chiari I malformation patients (<18 years) treated surgically at our institute were retrospectively studied. Results: During the study period between January 1999 and June 2011, fifty patients, aged ≤18 years with Chiari malformation, were treated surgically and formed the basis for this series. There were 21 female children (42%) and 29 male children (58%), with a female-to-male ratio of 1:1. At the last follow-up, oropharyngeal symptoms were improved in 33% (n = 3/9). Headache/neck/back pain improved in 69.56% of children (n = 16/23). Upper-extremity pain/weakness/numbness improved in 73.91% of children (n = 17/23). Ataxia improved in 66.66% of children (n = 4/6). Lower-limb weakness/hyperreflexia improved in 83.33% of children (n = 5/6). At follow-up, magnetic resonance imaging for patients with syrinx was available for 75% of patients (n = 30/50) and not available for 25% of patients (n = 10/40). Syrinx was diminished in size or resolved in 66.33% of patients (n = 19/30) and the remaining was same for 36.66% of patients (n = 11/30). Conclusions: The main goal of surgery is to arrest the progression of neurological deficits. Foramen magnum decompression with a lax duroplasty is the surgical procedure of choice.
Construct Validation and Reliability Assessment of Tamil Version of Epworth Sleepiness Scale to Evaluate Daytime Sleepiness among Adolescents in Rural Puducherry, South India
Authors: Krishnamoorthy Yuvaraj , Sarveswaran Gokul , Sakthivel Manikandanesan , Kalaiselvy A. , Majella Marie Gilbert , Lakshminarayanan Subitha 
Published: October 2018

ABSTRACT
Background: Epworth sleepiness scale (ESS) has been used widely in the assessment of daytime sleepiness for research and clinical purposes. Hence, this study was done to translate the ESS in Tamil and to assess the construct validity and reliability of the Tamil version among adolescents in rural Puducherry, South India. Materials and Methods: Translation of the ESS by native language experts and pilot tested with subsample of adolescents. Final Tamil version was administered among 789 Tamil-speaking adolescents in the selected villages of rural Puducherry (union territory in South India). Construct validity was assessed by exploratory factor analysis through principal component method. Confirmatory factor analysis was done to obtain the goodness-of-fit. Reliability of questionnaire was assessed through Cronbach's alpha coefficient. Results: Two factor structures were obtained with Eigenvalues of 3.49 and 1.09, respectively. Both factors accounted for about 57.4% of the variance. Two-factor model assessed by confirmatory factor method found Chi-square value of 215.57 (P < 0.001). Goodness-of-fit revealed acceptable comparative fit indices (0.91). The reliability coefficient (Cronbach's alpha) for complete ESS was 0.81. Factor-based analysis showed that the Cronbach's reliability coefficient was 0.83 and 0.75 for the first and second factor, respectively. Conclusion: Our study concludes that the ESS questionnaire is internally valid and consistent with good reliability coefficient for application in Tamil-speaking rural adolescents. However, further research can be done to content validate the questionnaire with standard diagnostic tool.
Clinical Case Presentation on Absence Seizures Diagnosis and Treatment Care Services and Outcomes in an Adult Patient
Authors: Umashankar M. S. , Kumar A. Bharath 
Published: October 2018

ABSTRACTAbsence seizures are often associated with impaired or loss of consciousness clinically proved to have an impact on motor and cognitive abnormalities of the nerve cells of the brain. Seizure admits several etiopathophysiological events leading to several neurofunctional changes in the reticulothalamocortical circuitry zones of the central nervous system. This paves the episodes of absence seizure events. A clinical case report of absence seizure in a 25 years age adult patient came to the hospital with impaired consciousness. The brain magnetic resonance imaging scanning of the patient detected a small focal flair hypertensive area in the right parasellar region close to cavernous sinus with mild flair hypersensitivity in the left cavernous sinuses, right maxillary, and ethmoid sinusitis. The electroencephalogram of the brain showed normal waves with electrode artifacts was observed. The patient was confirmed with absence seizures, and he was treated with oxcarbazepine 150 mg twice daily. The patient was recovered from seizure and discharged with medications. He was called for follow-up examination once in 3-month period.
A thermodynamic description for the hygroscopic growth of atmospheric aerosol particles
Authors: Castarède Dimitri , Thomson Erik S. 
Published: October 2018

Abstract. The phase state of atmospheric particulate is important to atmospheric
processes, and aerosol radiative forcing remains a large uncertainty in
climate predictions. That said, precise atmospheric phase behavior is
difficult to quantify and observations have shown that “precondensation” of
water below predicted saturation values can occur. We propose a revised
approach to understanding the transition from solid soluble particles to
liquid droplets, typically described as cloud condensation nucleation – a
process that is traditionally captured by Köhler theory, which describes
a modified equilibrium saturation vapor pressure due to (i) mixing entropy
(Raoult's law) and (ii) droplet geometry (Kelvin effect). Given that
observations of precondensation are not predicted by Köhler theory, we
devise a more complete model that includes interfacial forces giving rise to
predeliquescence, i.e., the formation of a brine layer wetting a salt
particle at relative humidities well below the deliquescence point.
Business Model and Innovation at a Public Company in the Agroindustrial Coffee Chain
Authors: Franco João Marcos Caixeta , Figueira Mariane , Sugano Joel Yutaka , Silva Sabrina Soares da 
Published: October 2018

Objective: Our objective was to evaluate, through the analysis of the ‘business model,’ the strategy of a public agricultural research company for the creation and launch of an innovation for the agro-industrial coffee chain. Method: We developed a single instrumental case study for the qualitative research. For data collection we used bibliographic and documentary research, as well as in-depth interviews and analyzed based on the thematic content analysis technique. The instrumental case study has proved to be the most suitable methodology since it is used when a particular case is examined to provide information on an issue that can be generalized and used to understand a larger reality. Originality/relevance: In this paper we reexamined an unsuccessful innovation case associated with the lens of the business model theoretical construct. This paper is willing to raise issues that restrict innovation in public research companies. Results: The paper unveiled difficulties related to the inconsistency of innovation promotion policies and legal uncertainty, in particular, by the contradictory positions of legal advisors, which inhibit researchers from engaging in innovative activities and in partnerships with private companies. Theoretical/methodological contributions: The instrumental case study developed, together with the analysis based on the construct of the business model, allowed a better understanding of the problems faced in public research environments in Brazil. This analysis can be applied to similar cases, since the issue of innovation in the public sector and the difficulties of appropriateness are common to other companies.
Public Management: Formation of a Constructivist Model to Support the Virtual School of Public Administration of Santa Catarina in Combating the Evasion of Distance Learning
Authors: Ensslin Sandra Rolim , Amaral Barbara Gonçalves , Valmorbida Sandra Mara Iesbik , Dutra Ademar 
Published: October 2018

Objective: We aimed to form a constructivist model that subsidizes the management of the Moodle site of training courses offered by the Virtual School of Public Administration of the State of Santa Catarina (SEA-SC), with regard to combating the evasion of registered students.Methodology / Approach: We adopted Multi-criteria Decision Support-Constructivist methodology (MDSC) to support the construction of the model based on the decision-makers’ perspective (School Director and SEA Administrator). For the selection of the theoretical contribution, we used the Knowledge Development Process-Constructivist (ProKnow-C). An epistemological constructivism approach was adopted.Originality / Relevance: In the current literature on distance training, there is a gap in the process to evaluate an evasion in these courses and, consequently, to aid the decision-making process of its managers and planners.Main results: Based on the knowledge generated by the managers, we found: (i) 13 aspects were considered necessary to evaluate the performance of the training courses, via the Moodle site, and for these, ordinal scales were constructed and their reference levels have been defined; (ii) the status quo in the 13 indicators of the ad hoc model was identified; (iii) the ‘Evasion Management’ area evidenced the need for improvement actions in these aspects: simultaneous tutorials and inscriptions in multiple courses; and (iv) some variances between the aspects (indicators) proposed in the literature and those considered relevant by managers; characteristic of investigations guided by the qualitative approach and constructivist epistemology.Theoretical / Methodological Contribution: This article presents the duality about the understanding of the process and the avoidance factors of the training courses between literature and empirical perception. We identified that conducting constructivist bases by considering the values, goals and perceptions of the context can result in a legitimate (model) instrument.
Les recherches conjointes : un fait socio-anthropologique contemporain
Authors: Soulière Marguerite , Fontan Jean-Marc 
Published: October 2018

Le constat qui sert de ligne éditoriale et de fil rouge à ce numéro est le suivant : en matière de production scientifique des connaissances, une transformation en profondeur s’opère depuis quelques décennies tant à l’échelle de la société que des sciences sociales. Le processus innovant que nous observons est caractérisé par la volonté d’acteurs sociaux d’être partie prenante des processus de production et de valorisation des savoirs portant sur les objets qui les concernent. Cette exigence épistémique correspond aussi au besoin exprimé et mis en pratique par un nombre de plus en plus important de chercheurs universitaires. Le fait de travailler « avec », de « façon conjointe », dans une « recherche collaborative » ou « participative » et parfois en « partenariat », rend compte de la possibilité d’ouvrir la science, d’en démocratiser les dimensions de travail et aussi de questionner la portée performative de cette façon de générer de nouvelles connaissances.
Un savoir solidaire Nord/Sud : le projet Louisiane et le défi de l'engagement
Authors: Bruce Clint 
Published: October 2018

Vers le milieu des années 1970, le Projet Louisiane (PL) a mobilisé une équipe pluridisciplinaire de chercheurs canadiens afin d’étudier la lointaine Louisiane francophone « dans toute sa complexité et toutes ses contradictions ». En examinant cette initiative, nous nous intéressons aux enjeux relatifs à l’esprit solidaire du PL vis-à-vis du renouveau ethnique alors en cours. Étude métascientifique, l’article s’oriente autour d’un double objectif : d’une part, cerner les postures multiples face aux milieux louisianais et, d’autre part, examiner les expériences d’assistants de recherche, québécois et louisianais, en tant quevécu conscientisantsusceptible de favoriser un engagement sur le plan ethnolangagier.
Chlamydia pneumoniae strain TWAR pharyngitis in US Air Force basic trainees
Authors: Hargreaves LT Col. James E. , Zajac Maj. Robert A , Kuo Cho-Chou , Wang San-Pin , Grayston J. Thomas 
Published: October 2018

Abstract
Chlamydia pneumoniae has recently been shown to be a cause of pharyngitis. Because the impact of this pathogen on United States Air Force basic trainees is unknown, the authors undertook a prospective study to evaluate the prevalence of C pneumoniae. Of 118 asymptomatic basic trainees, 43% had preexisting antibodies to C pneumoniae and 0.9% had serologic evidence of C pneumoniae infection. Of 226 symptomatic basic trainees, only four (1.8%) met the criteria for serologic evidence of acute C pneumoniae infection. No other cause of pharyngitis was found in three of four of these basic trainees. Three of the trainees with C pneumoniae infection had hoarseness and all had a dry cough. All symptoms resolved without specific antichlamydial therapy. Chlamydia pneumoniae was an uncommon cause of pharyngitis in basic trainees, appearing as a mild, self-limiting illness.
Drug and alcohol abuse and cholesterol levels
Authors: Gross George A. 
Published: October 2018

Abstract
An uncontrolled, retrospective study of 58 consecutive patients admitted to a hospital substance abuse unit assessed the effects of alcohol consumption on cholesterol levels. From the dietary histories completed by 54 of the patients, it was found that the alcoholics consumed a high-calorie diet containing a high percentage of foods with a high cholesterol content, but in small quantities. Most of their caloric intake was derived from the alcohoL Abusers of substances other than alcohol had a low-calorie intake of the same quality as alcoholics. It appears that low consumption of alcohol rather than something intrinsic in alcohol or other drugs is related to low levels of total cholesterol in persons consuming a high cholesterol-containing diet. The author also suggests that an unexplained relationship between low cholesterol levels and some gastrointestinal malignancies may be due to the effects of alcohol on the gastrointestinal tract.
Intraosseous infusion in pediatric patients
Authors: Neal Clifford J. , McKinley David F. 
Published: October 2018

Abstract
In traumatically \injured or medically unstable pediatric patients requiring resuscitation, gaining intravenous access often is frustrating for the physician and agonizing for the patient. Even when cardiopulmonary resuscitation is performed by trained professionals, cardiac arrests in children in the prehospital setting have a mortality of 79% to 100%. Immediate vascular access such as that obtained by intraosseous infusion improves survival. The intraosseous infusion technique uses the medullary cavity in the tibia as a ''noncollapsible vein" for parenteral infusion. It is indicated in a child in shock or cardiac arrest when two attempts to access peripheral vasculature have failed or when more than 2 minutes have elapsed in the attempt to gain access. Epinephrine, bicarbonate, calcium, lidocaine, and volume expanders can be infused via the intraosseous route. Complications rarely occur. The technique described here is gaining acceptance in both prehospital and emergency department settings.