bluuebunny/crossref_metadata_2025_split huggingface dataset:
Survival and specific outcome of sickle cell disease patients after renal transplantation
Authors: Gérardin Christel , Moktefi Anissa , Couchoud Cécile , Duquesne Alyette , Ouali Nacera , Gataut Philippe , Karras Alexandre , Anglicheau Dany , Lefaucheur Carmen , Figueres Lucile , Albano Laetitia , Lionet Arnaud , Novion Marine , Ziliotis Marie‐Julia , Louis Magali , Del Bello Arnaud , Matignon Marie , Dahan Karine , Habibi Anoosha , Galacteros Frederic , Bartolucci Pablo , Grimbert Philippe , Audard Vincent 
Published: July 2019

SummaryThe prognosis of sickle cell disease (SCD) patients who need dialysis is poor, but experience with kidney transplantation is limited. This study assessed the characteristics of 36 SCD patients undergoing renal transplantation. Immediate post‐surgical complications occurred in 25% of cases. Cytomegalovirus and bacterial infections were frequently observed. Twelve patients died after a median follow‐up period of 17·4 months. Overall patient survival was significantly lower in SCD than in the control group without significant difference for overall death‐censored graft survival. Our data suggest that renal transplantation should be systematically considered in SCD patients with end‐stage renal disease.
Pharmacology of bisphosphonates in pain
Authors: Tzschentke Thomas M. 
Published: July 2019

The treatment of pain, in particular, chronic pain, remains a clinical challenge. This is particularly true for pain associated with severe or rare conditions, such as bone cancer pain, vulvodynia, or complex regional pain syndrome. Over the recent years, there is an increasing interest in the potential of bisphosphonates in the treatment of pain, although there are few papers describing antinociceptive and anti‐hypersensitizing effects of bisphosphonates in various animal models of pain. There is also increasing evidence for clinical efficacy of bisphosphonates in chronic pain states, although the number of well‐controlled studies is still limited. However, the mechanisms underlying the analgesic effects of bisphosphonates are still largely elusive. This review provides an overview of preclinical and clinical studies of bisphosphonates in pain and discusses various pharmacological mechanisms that have been postulated to explain their analgesic effects.LINKED ARTICLESThis article is part of a themed issue on The molecular pharmacology of bone and cancer‐related bone diseases. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v178.9/issuetoc
The time frame of home‐range studies: from function to utilization
Authors: Péron Guillaume 
Published: July 2019

ABSTRACTAs technological and statistical innovations open new avenues in movement ecology, I review the fundamental implications of the time frame of home‐range studies, with the aim of associating terminologies consistently with research objectives and methodologies. There is a fundamental distinction between (a) extrapolations of stationary distributions, associated with long time scales and aiming at asymptotic consistency, and (b) period‐specific techniques, aiming at specificity but typically sensitive to the sampling design. I then review the difference between function and utilization in home‐range studies. Most home‐range studies are based on phenomenological descriptions of the time budgets of the study animals, not the function of the visited areas. I highlight emerging trends in automated pattern‐recognition techniques for inference about function rather than utilization.
Cancer therapy with major histocompatibility complex‐deficient and interferon β‐producing myeloid cells derived from allogeneic embryonic stem cells
Authors: Umemoto Satoshi , Haruta Miwa , Sakisaka Masataka , Ikeda Tokunori , Tsukamoto Hirotake , Komohara Yoshihiro , Takeya Motohiro , Nishimura Yasuharu , Senju Satoru 
Published: July 2019

AbstractWe previously established a method to generate myeloid cells with a proliferative capability from pluripotent stem cells and designated them iPS‐ML. Human iPS‐ML cells share features with physiological macrophages including the capability to infiltrate into cancer tissues. We observed therapeutic effects of human iPS‐ML cells expressing interferon β (iPS‐ML/interferon (IFN)‐β) in xenograft cancer models. However, assessment of host immune system‐mediated therapeutic and adverse effects of this therapy is impossible by xenograft models. We currently evaluated the therapeutic effects of a mouse equivalent of human iPS‐ML/IFN, a mouse embryonic stem (ES) cell‐derived myeloid cell line producing IFN (ES‐ML/IFN). The ES‐MLs producing IFN‐β (β‐ML) and IFN‐γ (γ‐ML) and originating from E14 ES cells derived from the 129 mouse strain (H‐2b) were generated, and the MHC (H‐2Kb, Db, and I‐Ab) genes of the ES‐ML/IFN were disrupted using the clustered regularly interspaced short palindromic repeats (CRISPR)/CAS9 method. We used the ES‐ML/IFN to treat allogeneic BALB/c mice (H‐2d) transplanted with Colon26 cancer cells. Treatment with β‐ML but not with γ‐ML cells repressed the growth of colon cancer in the peritoneal cavity and liver. The transferred ES‐ML/IFN infiltrated into cancer tissues and enhanced infiltration of T cells into cancer tissues. ES‐ML/IFN therapy increased the number of immune cells in the lymphoid organs. Sensitization of both cancer antigen‐specific CD8+ T cells and natural killer (NK) cells were enhanced by the therapy, and CD8+ T cells were essential for the therapeutic effect, implying that donor MHC‐deficient β‐ML exhibited a therapeutic effect through the activation of host immune cells derived from allogeneic recipient mice. The results suggested the usefulness of HLA‐deficient human iPS‐ML/IFN‐β cells for therapy of HLA‐mismatched allogeneic cancer patients.
Functional analysis of novel RUNX2 mutations identified in patients with cleidocranial dysplasia
Authors: Hordyjewska‐Kowalczyk Ewa , Sowińska‐Seidler Anna , Olech Ewelina M. , Socha Magdalena , Glazar Renata , Kruczek Anna , Latos‐Bieleńska Anna , Tylzanowski Przemko , Jamsheer Aleksander 
Published: July 2019

AbstractRUNX2 (Runt‐related transcription factor 2) is a master regulator of osteoblast differentiation, cartilage and bone development. Pathogenic variants in RUNX2 have been linked to the Cleidocranial dysplasia (CCD), which is characterized by hypoplasia or aplasia of clavicles, delayed fontanelle closure, and dental anomalies. Here, we report 11 unrelated Polish patients with CCD caused by pathogenic alterations located in the Runt domain of RUNX2. In total, we identified eight different intragenic variants, including seven missense and one splicing mutation. Three of them are novel: c.407T>A p.(Leu136Gln), c.480C>G p.(Asn160Lys), c.659C>G p.(Thr220Arg), additional three were not functionally tested: c.391C>T p.(Arg131Cys), c.580+1G>T p.(Lys195_Arg229del), c.652A>G p.(Lys218Glu), and the remaining two: c.568C>T p.(Arg190Trp), c.673C>T p.(Arg225Trp) were previously reported and characterized. The performed transactivation and localization studies provide evidence of decreased transcriptional activity of RUNX2 due to mutations targeting the Runt domain and prove that impairment of nuclear localization signal (NLS) affects the subcellular localization of the protein. Presented data show that pathogenic variants discovered in our patients have a detrimental effect on RUNX2, triggering the CCD phenotype.
Seasonal patterns of biodiversity in Mediterranean coastal lagoons
Authors: Bellino Alessandro , Mangano Maria Cristina , Baldantoni Daniela , Russell Bayden Dwight , Mannino Anna Maria , Mazzola Antonio , Vizzini Salvatrice , Sarà Gianluca 
Published: July 2019

AbstractAimUnderstanding and quantifying the seasonal patterns in biodiversity of phytobenthos, macro‐zoobenthos and fishes in Mediterranean coastal lagoons, and the species dependence upon environmental factors.LocationThe study was carried out in the “Stagnone di Marsala e Saline di Trapani e Paceco,” the largest coastal lagoon system in the central Mediterranean Sea (Sicily, Italy), a Special Protection Area located along one of the central ecological corridors joining Africa and Europe.MethodsThe coastal lagoon system was selected as a model ecosystem to investigate the seasonal variations in biodiversity indices and dominance–diversity relationships in phytobenthos, macro‐zoobenthos and fishes, and how seasonal variations in temperature, salinity, depth, inorganic and organic suspended matter affect the abundance of the species constituting these communities. Models of ecosystem structure, describing the interactions among functional groups and environmental variables, were also developed using confirmatory path analysis and artificial neural networks to exemplify their application in predicting temperature‐driven alterations.ResultsWide seasonal variations in biodiversity indices and dominance–diversity relationships across the communities of the coastal lagoon system were observed, driven by the dynamics in climate and resource availability. The effects of the environmental variables on taxon abundances varied in relation to the community, with the widest responses elicited in phytobenthos and fishes. Temperature was the main variable affecting taxon abundances in macro‐zoobenthos and was also the major driver of shallow water ecosystem structure.Main conclusionsThis research shed light on the seasonal variations in biodiversity of Mediterranean coastal lagoons, elucidating also the tight dependence of phytobenthos, macro‐zoobenthos and fish diversity upon environmental factors. The findings and the methodological approach proposed may be crucial in developing models able to predict future climate‐driven alterations in communities inhabiting these important and threatened ecosystems.
An evidence‐based approach to developing low‐carbohydrate diets for type 2 diabetes management: A systematic review of interventions and methods
Authors: Turton Jessica , Brinkworth Grant D. , Field Rowena , Parker Helen , Rooney Kieron 
Published: July 2019

AbstractAimTo identify core diet and delivery components of low‐carbohydrate (CHO) diets that have demonstrated efficacy for type 2 diabetes (T2D) management.Materials and methodsMEDLINE, Pre‐MEDLINE, EMBASE, CINAHL and the Cochrane Library of Controlled Trials databases were systematically searched from inception until August 18, 2018. Primary intervention studies of low‐CHO diets (≤130 g/d or 26% total energy intake [TEI]) were included. Content analysis was performed on the low‐CHO diet protocols classified as safe and effective for T2D management.ResultsA total of 41 studies published between 1963 and 2018 were included, of which 40 were classified as safe and effective for inclusion in the primary analysis. Thirteen studies (13/40) were on very‐low‐CHO diets (<50 g/d), 14/40 included low‐CHO diets (≤130 g/d or 26% TEI), and 13/40 were adapted according to participant progress. Thirty‐one studies reported a total energy prescription, of which 18/31 encouraged ad libitum intakes. Twenty studies reported a prescribed dietary fat amount, of which 18/20 were unrestricted or high‐fat (>35% TEI). Twenty‐six studies reported a prescribed dietary protein amount, of which 22 were unrestricted or were high‐protein (>25% TEI). The types of dietary CHO, fat and protein recommended were predominantly whole foods. Common delivery methods reported were dietician and/or physician involvement, moderate to high frequency of contact (≥1 session/month) and use of participant self‐monitoring.ConclusionsMultiple approaches for developing and delivering a low‐CHO diet intervention for T2D management are safe and effective. A comprehensive set of core dietary components to consider in the formulation of low‐CHO diet protocols were identified for use in clinical practice and to inform evidence‐based guidelines for T2D management.
Predation differentially structures immature mosquito populations in stormwater ponds
Authors: Holmes Christopher J. , Cáceres Carla E. 
Published: July 2019

1. Understanding the factors underlying the abundance and distribution of species requires the consideration of a complex suite of interacting biotic and abiotic factors operating on multiple spatial and temporal scales. Larval mosquitoes inhabiting small human‐constructed ponds represent a unique opportunity to investigate the relative importance of these structuring mechanisms while simultaneously generating applied knowledge on mosquito control.2. A multi‐year field survey of 32 stormwater ponds was conducted in central Illinois (Champaign County). From each pond, data were collected on pond structure type and hydroperiod, the presence/absence of cattails (Typha spp.), and measures of total nitrogen, phosphorus, and organic carbon, and chlorophyll a. The communities of crustacean zooplankton and aquatic insects were characterised, and these taxa were assigned into two main groups: predators and competitors of larval mosquitoes. Structural equation modelling was used to explore the direct and indirect effects of these biotic and abiotic factors on larval density for three species of culicine mosquitoes (Culex pipiens, Culex restuans, and Aedes vexans).3. Hydroperiod had an indirect negative effect on C. pipiens density. However, this effect was mediated by predator density; more permanent ponds had more predators, which therefore reduced the density of C. pipiens larvae. Aedes vexans density was positively correlated with predator density. No predictor variables were found that explained variation in C. restuans density.4. This study show that the relative importance of these biotic and abiotic factors varies among species of culicine mosquitoes inhabiting stormwater ponds.
Arthropod carrion influences plant choice, oviposition, and cannibalism by a specialist predator on a sticky plant
Authors: Nelson Peter N. , Burrack Hannah J. , Sorenson Clyde E. 
Published: July 2019

1. Dead arthropods, entrapped by trichomes on plant surfaces, are an underappreciated form of plant‐provided food. Specialist predatory arthropods able to manoeuvre on plants covered in trichomes facultatively scavenge on the alternative food resource, increasing their abundance and reducing plant damage by herbivores.2. This protective mutualism dependent on arthropod carrion has been demonstrated in several plant species, but the mechanisms driving the increase in predator abundance have not been identified. Through a series of greenhouse and laboratory experiments, the effect of arthropod carrion on predator behaviour was assessed.3. The predatorJalysus wickhamipreferredNicotiana tabacumplants augmented with arthropod carrion, spending significantly more time and laying more eggs on those plants than plants without arthropod carrion.4. Under lowJ. wickhamidensities, arthropod carrion did not reduce egg cannibalism by adults. Under high densities, egg cannibalism byJ. wickhamiadults was reduced in the presence of arthropod carrion, but cannibalism by fifth instars was not.5. Arthropod carrion may be utilised by a wide range of predatory arthropods that facultatively scavenge, and this research demonstrates its potential for influencing arthropod–plant and arthropod–arthropod interactions.
Migration matters: How migration is critical to contemporary human–environment geography
Authors: Jokisch Brad D. , Radel Claudia , Carte Lindsey , Schmook Birgit 
Published: July 2019

AbstractHuman migration plays a critical role in numerous contemporary environmental concerns including global climate change and environmental justice. This review characterizes the ways migration is critical to contemporary human–environment geography. We delineate four themes from the literature based on (a) how migration affects the environment; (b) how the environment and/or environmental events affect migration; (c) how migration produces uneven environmental benefits and burdens; and (d) how environmental displacement/dispossession produces migration and vice versa. We articulate five recommendations for a research agenda that integrates migration processes, recognizes migration as a heterogeneous process, and approaches human–environment interactions holistically and non‐deterministically.
Validation of the Oral Health Impact on Daily Life Questionnaire (OHIDL) among Hong Kong older adults
Authors: Liu Jian , Wong May Chun Mei , Lo Edward Chin Man 
Published: July 2019

AbstractBackgroundThe Oral Health Impact on Daily Life Questionnaire (OHIDL) was developed through a qualitative study to measure oral health‐related quality of life, including intensity and bother measurements, among older adults in Hong Kong. The instrument comprises 20 items divided into eight domains.ObjectivesThis study describes the psychometric properties of the OHIDL and refines the instrument through validity and reliability testing.Materials and methodsThe OHIDL was administered to older adults who attended dental clinics for general dental treatments. Items with low discriminant ability were to be eliminated. Construct validity was assessed through convergent, divergent and factorial validity. Criterion validity was investigated by assessing the correlation between the measurements and the global questions. Reliability was assessed with Cronbach's alpha.ResultsIn total, 306 participants (mean age: 69.6 years) completed the interviews. Two items for which over 90% of the participants reported no impact and two items with poor discriminant validity were eliminated. Both intensity and bother measurements demonstrated good construct and criterion validity, with the intensity measurement showing better performance being selected for the OHIDL to reduce the respondents’ burden. The intensity measurement also showed satisfactory internal consistency.ConclusionsThe refined OHIDL with 16 items in seven domains is valid and reliable in measuring the oral health impacts on daily life among Hong Kong older adults.
High‐Precision Cd Isotope Measurements of Soil and Rock Reference Materials by MC‐ICP‐MS with Double Spike Correction
Authors: Liu Meng‐Shu , Zhang Qun , Zhang Yingnan , Zhang Zhaofeng , Huang Fang , Yu Hui‐Min 
Published: July 2019

This study presents a high‐precision Cd isotope measurement method for soil and rock reference materials using MC‐ICP‐MS with double spike correction. The effects of molecular interferences (e.g., 109Ag1H+, 94Zr16O+, 94Mo16O+ and 70Zn40Ar+) and isobaric interferences (e.g., Pd, In and Sn) to Cd isotope measurements were quantitatively evaluated. When the measured solution has Ag/Cd ≤ 5, Zn/Cd ≤ 0.02, Mo/Cd ≤ 0.4, Zr/Cd ≤ 0.001, Pd/Cd ≤ 5 × 10−5 and In/Cd ≤ 10−3, the measured Cd isotope data were not significantly affected. The intermediate measurement precision of pure Cd solutions (BAM I012 Cd, Münster Cd and AAS Cd) was better than ± 0.05‰ (2s) for δ114/110Cd. The δ114/110Cd values of soil reference materials (NIST SRM 2709, 2709a, 2710, 2710a, 2711, 2711a and GSS‐1) relative to NIST SRM 3108 were in the range of −0.251 to 0.632‰, the δ114/110Cd values of rock reference materials (BCR‐2, BIR‐1, BHVO‐2, W‐2, AGV‐2, GSP‐2 and COQ‐1) varied from −0.196‰ to 0.098‰, and that of the manganese nodule (NOD‐P‐1) was 0.163 ± 0.040‰ (2s, n = 8). The large variation in Cd isotopes in soils and igneous rocks indicates that they can be more widely used to study magmatic and supergene processes.
Solving Groundwater Flow Problems with Time Series Analysis: You May Not Even Need Another Model
Authors: Bakker Mark , Schaars Frans 
Published: July 2019

AbstractTime series analysis is a data‐driven approach to analyze time series of heads measured in an observation well. Time series models are commonly much simpler and give much better fits than regular groundwater models. Time series analysis with response functions gives insight into why heads vary, while such insight is difficult to gain with black box models out of the artificial intelligence world. An important application is to quantify the contributions to the head variation of different stresses on the aquifer, such as rainfall and evaporation, pumping, and surface water levels. Time series analysis may be applied to answer many groundwater questions without the need for a regular groundwater model, such as what is the drawdown caused by a pumping station? Or, how long will it take before groundwater levels recover after a period of drought? Even when a regular groundwater model is needed to solve a groundwater problem, time series analysis can be of great value. It can be used to clean up the data, identify the major stresses on the aquifer, determine the most important processes that affect flow in the aquifer, and give an indication of the fit that can be expected. In addition, it can be used to determine calibration targets for steady‐state models, and it can provide several alternative calibration methods for transient models. In summary, the overarching message of this paper is that it would be wise to do time series analysis for any application that uses measured groundwater heads.
Three criteria for radiological response on survival in patients with hepatocellular carcinoma treated with lenvatinib
Authors: Kaneko Shun , Tsuchiya Kaoru , Kurosaki Masayuki , Kirino Sakura , Inada Kento , Yamashita Koji , Osawa Leona , Hayakawa Yuka , Sekiguchi Shuhei , Watakabe Keiya , Okada Mao , Wang Wan , Shimizu Takao , Higuchi Mayu , Takaura Kenta , Maeyashiki Chiaki , Tamaki Nobuharu , Yasui Yutaka , Takeguchi Takaya , Takeguchi Yuko , Nakanishi Hiroyuki , Itakura Jun , Takahashi Yuka , Himeno Yoshiro , Izumi Namiki 
Published: July 2019

AimLenvatinib (LEN) is a newly approved, multikinase inhibitor for treating unresectable hepatocellular carcinoma. In the present study, we investigated the impact of three different criteria for evaluating radiological objective response (OR) on overall survival in real‐world data.MethodsConsent for LEN therapy was obtained from 51 patients from April 2018 to March 2019. A total of 40 patients who received a minimal cumulative duration of 4 weeks of LEN were included in the analysis. Enhanced computed tomography scan was performed at baseline and every 4–8 weeks after LEN administration. Overall survival and OR were assessed with three different evaluations, as follows: Response Evaluation Criteria in Solid Tumors 1.1, modified Response Evaluation Criteria in Solid Tumors, and Choi criteria.ResultsThe average observation period for all participants after LEN introduction was 209.4 ± 77.5 days. The Response Evaluation Criteria in Solid Tumors 1.1, modified Response Evaluation Criteria in Solid Tumors, and Choi criteria identified 10 of 40 (25.0%), 15 of 40 (37.5%), and 18of 40 (45.0%) patients with OR, respectively. The median overall survival in progressive disease evaluated by each criterion was 227 days. This result was significantly shorter than OR. Furthermore, the cumulative duration of LEN administration (>150 days) represented a significant prognostic factor (HR 0.160. 95% CI 0.039–0.646, P = 0.001).ConclusionThe Response Evaluation Criteria in Solid Tumors 1.1, modified Response Evaluation Criteria in Solid Tumors, and Choi criteria were useful therapeutic evaluation methods in LEN therapy for unresectable hepatocellular carcinoma. LEN's appropriate effect evaluation and management might lead to a better prognosis.