bluuebunny/crossref_metadata_2025_split huggingface dataset:
Calculation of surface tensions for liquid mixtures using the SWCF‐VR EOS and Butler‐type method
Authors: Li Jinlong , He Changchun , Peng Changjun , Liu Honglai 
Published: May 2019

AbstractA generalized surface tension model for various types of liquid mixtures by coupling the equation of state for square‐well chain fluids with variable ranges and Butler type method was presented. Transferable molecular parameters fitted from experimental pVT of pure fluids were used. The reliability of this model were tested with liquid mixtures including 87 conventional fluid mixtures, 20 aqueous alcohol‐amine solutions, 12 ionic liquid solutions, 7 polymer solutions, and 4 liquid alloys. The overall average absolute deviations in correlations with one parameter for all binary mixtures, in predictions for all conventional binary mixtures except aqueous solutions and for all ternary mixtures are 1.94%, 1.82%, and 2.69%, respectively. The potential application of the model in simultaneously describing the phase equilibrium and surface tensions was partially verified. The results demonstrate that this model has an overall robustness and reliability in calculations of surface tensions for various liquid mixtures.
A multicenter retrospective study of charcot‐marie‐tooth disease type 4B (CMT4B) associated with mutations in myotubularin‐related proteins (MTMRs)
Authors: Pareyson Davide , Stojkovic Tanya , Reilly Mary M. , Leonard‐Louis Sarah , Laurà Matilde , Blake Julian , Parman Yesim , Battaloglu Esra , Tazir Meriem , Bellatache Mounia , Bonello‐Palot Nathalie , Lévy Nicolas , Sacconi Sabrina , Guimarães‐Costa Raquel , Attarian Sharham , Latour Philippe , Solé Guilhem , Megarbane André , Horvath Rita , Ricci Giulia , Choi Byung‐Ok , Schenone Angelo , Gemelli Chiara , Geroldi Alessandro , Sabatelli Mario , Luigetti Marco , Santoro Lucio , Manganelli Fiore , Quattrone Aldo , Valentino Paola , Murakami Tatsufumi , Scherer Steven S. , Dankwa Lois , Shy Michael E. , Bacon Chelsea J. , Herrmann David N. , Zambon Alberto , Tramacere Irene , Pisciotta Chiara , Magri Stefania , Previtali Stefano C. , Bolino Alessandra 
Published: May 2019

ObjectiveCharcot‐Marie‐Tooth (CMT) disease 4B1 and 4B2 (CMT4B1/B2) are characterized by recessive inheritance, early onset, severe course, slowed nerve conduction, and myelin outfoldings. CMT4B3 shows a more heterogeneous phenotype. All are associated with myotubularin‐related protein (MTMR) mutations. We conducted a multicenter, retrospective study to better characterize CMT4B.MethodsWe collected clinical and genetic data from CMT4B subjects in 18 centers using a predefined minimal data set including Medical Research Council (MRC) scores of nine muscle pairs and CMT Neuropathy Score.ResultsThere were 50 patients, 21 of whom never reported before, carrying 44 mutations, of which 21 were novel and six representing novel disease associations of known rare variants. CMT4B1 patients had significantly more‐severe disease than CMT4B2, with earlier onset, more‐frequent motor milestones delay, wheelchair use, and respiratory involvement as well as worse MRC scores and motor CMT Examination Score components despite younger age at examination. Vocal cord involvement was common in both subtypes, whereas glaucoma occurred in CMT4B2 only. Nerve conduction velocities were similarly slowed in both subtypes. Regression analyses showed that disease severity is significantly associated with age in CMT4B1. Slopes are steeper for CMT4B1, indicating faster disease progression. Almost none of the mutations in the MTMR2 and MTMR13 genes, responsible for CMT4B1 and B2, respectively, influence the correlation between disease severity and age, in agreement with the hypothesis of a complete loss of function of MTMR2/13 proteins for such mutations.InterpretationThis is the largest CMT4B series ever reported, demonstrating that CMT4B1 is significantly more severe than CMT4B2, and allowing an estimate of prognosis. ANN NEUROL 2019
Production and characterization of starch‐based films reinforced by ramie nanofibers (Boehmeria nivea)
Authors: Marques Geovana Silva , de Carvalho Guilherme Ribeiro , Marinho Nelson Potenciano , de Muniz Graciela Inês Bolzón , de Matos Jorge Luiz Mário , Jorge Regina Maria Matos 
Published: May 2019

ABSTRACTIn this study, the use of cellulose nanofibers from ramie, a plant species with important characteristics of reinforcement, was investigated in the production of bio‐based polymer films. A central composite rotatable design was applied to produce the films, analyze the effects of cassava starch, glycerol, and nanofibers content on their properties, obtain mathematical models, response surface plots, and determine an optimum composition. The films produced were characterized by mechanical properties, water vapor permeability (WVP), solubility, and opacity. Microstructure and thermal behavior were also evaluated. The ramie nanofibers content had a positive effect on mechanical and barrier properties, as it increased tensile strength by 207.9%, and decreased WVP and solubility by 52.9 and 72.9%, respectively. Furthermore, the obtained films exhibited homogeneous and cohesive structures, which encourages the use of ramie nanofibers as a reinforcement material in the production of green plastics. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 47919.
Synthesis of light and dual‐redox triple‐stimuli‐responsive core‐crosslinked micelles as nanocarriers for controlled release
Authors: Ma Xiao , Liu Jiangtao , Lei Lei , Yang Hong , Lei Zhongli 
Published: May 2019

ABSTRACTStimulus‐responsive polymeric nanoparticles have great potential as nanocarriers. Here, triple‐stimuli‐responsive core‐crosslinked (CCL) micelles were developed that were convenient for drug delivery by taking advantage of dual‐redox and UV light synergistic triggers. Amphiphilic block copolymers methoxy poly(ethylene glycol)‐b‐poly(3‐azido‐2‐hydroxy‐propyl methacrylate‐co‐ο‐nitrobenzyl methacrylate) [mPEG‐b‐P(GMA‐N3‐co‐NBM)] were synthesized via atom transfer radical polymerization and ring‐opening reaction of ethylene oxide; these block copolymers can spontaneously self‐assemble into noncrosslinked (NCL) micelles. Afterward, CCL micelles were prepared using an alkyne‐functionalized crosslinking agent. Furthermore, the CCL micelles showed an excellent Nile Red dye molecule encapsulation, light and dual‐redox‐responsive performance, and increasing release rate of the dye as the concentration of glutathione and light irradiation increased. The triple‐stimuli‐responsive CCL micelles showed excellent stability and controllable release compared to NCL micelles. Therefore, we have developed a new smart nanocarrier, and the triple‐stimuli‐responsive CCL micelles could also be a potential delivery system in cancer therapy. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 47946.
Complex membrane of cellulose and chitin nanocrystals with cationic guar gum for oil/water separation
Authors: Yagoub Hajo , Zhu Liping , Shibraen Mahmoud H. M. A. , Xu Xiaowei , Babiker Dafaalla M. D. , Xu Jian , Yang Shuguang 
Published: May 2019

ABSTRACTIn an effort to develop a membrane system with low cost and easy fabrication process for oil/water separation, cellulose nanocrystals (CNC), chitin nanocrystals (ChiNC), and cationic guar gum (CGG) are used to prepare a complex membrane on top of a poly(ethylene terephthalate) (PET) nonwoven fabric via a vacuum filtration method. The interactions among CNC, ChiNC, and CGG complexation are discussed, and the functionalization of the PET nonwoven fabric with these polysaccharide derivatives provides a high rate of water absorption and permeability on applying pressure. The morphology and wettability studies demonstrate that the as‐prepared membrane has a porous structure and exhibits hydrophilic and underwater superoleophobic properties. The results of separation experiments show that the membrane can effectively separate oil/water emulsions with a relatively high flux and rejection ratio. This low‐cost process can easily be scaled up to fabricate complex membranes for oil/water separation. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 47947.
Responsiveness of Serum C‐Reactive Protein, Interleukin‐17A, and Interleukin‐17F Levels to Ustekinumab in Psoriatic Arthritis: Lessons From Two Phase III, Multicenter, Double‐Blind, Placebo‐Controlled Trials
Authors: Siebert Stefan , Sweet Kristen , Dasgupta Bidisha , Campbell Kim , McInnes Iain B. , Loza Matthew J. 
Published: May 2019

ObjectiveTo evaluate the associations of C‐reactive protein (CRP) and circulating Th17‐associated cytokine levels with psoriatic arthritis (PsA) disease activity and therapeutic response to ustekinumab.MethodsInterleukin‐17A (IL‐17A), IL‐17F, IL‐23, and CRP concentrations were measured in serum samples collected as part of the 2 PSUMMIT phase III studies of ustekinumab in PsA (n = 927). In post hoc analyses, relationships of IL‐17A, IL‐17F, and CRP levels at baseline, week 4, and week 24 with baseline skin and joint disease activity and response to therapy were evaluated using generalized linear models and Pearson's product‐moment correlation tests.ResultsBaseline serum levels of IL‐17A and IL‐17F were positively correlated with baseline skin disease scores (r = 0.39–0.62). IL‐23 levels were correlated with skin disease scores to a lesser extent (r = 0.26–0.31). No significant correlations were observed between these cytokine or CRP levels and baseline joint disease activity. There was no significant association of baseline levels of IL‐17A, IL‐17F, IL‐23, or CRP with therapeutic response to ustekinumab in either the skin or joints. Significant reductions from baseline in levels of IL‐17A, IL‐17F, and CRP were seen in patients treated with ustekinumab compared to those treated with placebo. Ustekinumab‐treated patients in whom 75% improvement in the Psoriasis Area and Severity Index score or 20% improvement according to the American College of Rheumatology criteria was achieved after 24 weeks of treatment had greater reductions in CRP level (geometric mean decreases of 51–58% versus 32–33%; P < 0.05), but not IL‐17A or IL‐17F levels, than nonresponders.ConclusionBaseline serum IL‐23/IL‐17 levels correlated with skin, but not joint, disease activity, suggesting tissue‐specific variation. However, neither baseline Th17‐associated cytokine levels nor CRP level were predictive of therapeutic response to ustekinumab in the skin or joints, despite rapid reductions in their levels following ustekinumab therapy.
Cadaveric Dissection in Relation to Problem‐Based Learning Case Sequencing: A Report of Medical Student Musculoskeletal Examination Performances and Self‐Confidence
Authors: Thompson Kristjan L. , Gendreau Julian L. , Strickling Jarred E. , Young Henry E. 
Published: May 2019

Mercer University School of Medicine utilizes a problem‐based learning (PBL) curriculum for educating medical students in the basic clinical sciences. In 2014, an adjustment was piloted that enabled PBL cases to align with their corresponding cadaver dissection that reviewed the content of anatomy contained in the PBL cases. Faculty had the option of giving PBL cases in sequence with the cadaveric dissection schedule (sequential group) or maintaining PBL cases out of sequence with dissections (traditional group). During this adjustment, students’ academic performances were compared. Students’ perception of their own preparedness for cadaveric dissection, their perceived utility of the cadaver dissections, and free‐response comments were solicited via an online survey. There were no statistically significant differences when comparing student mean examination score values between the sequential and traditional groups on both multidisciplinary examinations (79.39 ± 7.63 vs. 79.88 ± 7.31, P = 0.738) and gross anatomy questions alone (78.15 ± 10.31 vs. 79.98 ± 9.31, P = 0.314). A statistically significant difference was found between the sequential group's and traditional group's (63% vs. 29%; P = 0.005) self‐perceived preparedness for cadaveric dissections in the 2017 class. Analysis of free‐response comments found that students in the traditional group believed their performance in PBL group, participation in PBL group and examination performance was adversely affected when compared to students with the sequential schedule. This study provides evidence that cadaveric dissections scheduled in sequence with PBL cases can lead to increased student self‐confidence with learning anatomy but may not lead to improved examination scores.
Simultaneous determination of evobrutinib and its metabolite evobrutinib‐diol in dog plasma by liquid chromatography combined with electrospray ionization tandem mass spectrometry
Authors: Yang Jie , Yu Haiyang , Tang Qingmeng 
Published: May 2019

AbstractA rapid and sensitive liquid chromatography hyphenated with electrospray ionization tandem mass spectrometric method (LC–ESI–MS/MS) was developed and validated for simultaneous determination of evobrutinib and evobrutinib‐diol in dog plasma. The plasma sample was processed using acetonitrile and chromatographic separation was carried out on a Waters Acquity BEH C18 column (50 × 2.1 mm, 1.7 μm). The mobile phase was composed of 0.1% formic acid and acetonitrile, with an optimized gradient elution at a flow rate of 0.4 mL/min. Detection was accomplished in selective reaction monitoring mode via electrospray ionization interface operated in positive ion mode. The precursor‐to‐product transitions for quantification were m/z 430.2 → 98.1 for evobrutinib, m/z 464.2 → 98.1 for evobrutinib‐diol and m/z 441.2 → 138.1 for ibrutinib (internal standard). The developed assay was linear over the tested concentration ranges with correlation coefficient >0.995. The LLOQ was 0.1 ng/mL for both analytes. The inter‐ and intra‐day precisions were <9.65% and the accuracy ranged from −3.94 to 6.37%. The extraction recovery was >85.41% and no significant matrix effect was observed. The developed assay was successfully applied to the pharmacokinetic study of evobrutinib and evobrutinib‐diol in dogs after oral administration of evobrutinib at a single dose of 5 mg/kg.
Screening, and identification of the binding position, of xanthine oxidase inhibitors in the roots of Lindera reflexa Hemsl using ultrafiltration LC–MS combined with enzyme blocking
Authors: Fu Yu , Yang Jingfan , Chen Suiqing , Sun Xiaoya , Zhao Peng , Xie Zhishen 
Published: May 2019

AbstractA method based on enzyme blocking combined with ultrafiltration liquid chromatography–mass spectrometry (LC–MS) has been developed to identify xanthine oxidase (XOD) inhibitors in the roots of Lindera reflexa Hemsl (LR) and determine their binding positions. Allopurinol and febuxostat, known XOD inhibitors, which occupy different binding positions in XOD, were used as blockers and pre‐incubated with XOD. Then the LR extract was incubated without XOD, and with XOD, allopurinol‐blocked XOD and febuxostat‐blocked XOD before ultrafiltration LC–MS was performed. By comparing the chromatographic profiles of the incubation samples, not only the ligands, but also the binding position of these ligands with XOD could be determined. Finally, three compounds, pinosylvin, pinocembrin and methoxy‐5‐hydroxy‐trans‐stilbene, were identified as potential XOD inhibitors and the binding modes of these three compounds were shown to be similar to those of febuxostat. To verify the XOD inhibitory activity of the screened compounds, the microplate method and molecular docking in silico were used to evaluate the enzyme inhibitory activities and the binding positions with XOD. The results showed that the developed method could screen for XOD ligands in LR extracts and also determine the binding positions of the ligands. To our knowledge, this is the first report of the XOD inhibitory activity of these three compounds.
Business adaptation to climate change: American ski resorts and warmer temperatures
Authors: Rivera Jorge , Clement Viviane 
Published: May 2019

AbstractHow do firms adapt to the intensity of adverse chronic conditions stemming from the natural environment? We seek to contribute to the debate on whether environmental adversity tends to be positively or negatively related to adaptation. We propose that both diverging perspectives tend to predict part of firms' adaptation to nature adversity intensity. This is because of the interplay between latent counterbalancing mechanisms. First, at mild levels of nature adversity intensity, organizational inertial forces constrain organizations' willingness to adapt. Second, at medium levels of nature adversity intensity, coalition building and internal organizational politics allow managers to deploy adaptation resilience capabilities. Third, at severe levels, growing natural forces eventually impose limits beyond which protective adaptation becomes unviable. Our findings from a 2001 to 2013 analysis of western U.S. ski resorts' adaptation to temperature conditions indicate that firms facing medium levels of nature adversity intensity appear more likely to engage in higher levels of adaptation whereas those experiencing lower and higher intensity show a tendency for lower levels of adaptation, yielding an inverted U‐shaped relationship.
Optimizing checkpoint inhibitors therapy for relapsed or progressive classic Hodgkin lymphoma by multiplex immunohistochemistry of the tumor microenvironment
Authors: Carbone Antonino , Gloghini Annunziata , Pruneri Giancarlo , Dolcetti Riccardo 
Published: May 2019

AbstractImmune checkpoint‐blocking antibodies have therapeutic activity against relapsed or progressive classic Hodgkin lymphoma (cHL), but Hodgkin Reed‐Sternberg cells can develop resistance to this therapy via multiple mechanisms. To improve the efficacy of immune checkpoint blockade, we need a more precise understanding of the immune escape mechanisms active in individual cHL patients, and this requires a detailed characterization of immune cell populations in the tumor microenvironment. These cell‐cell interactions can now be studied by multiplex immunohistochemistry coupled to digital image analysis. This method should allow the identification of actionable target molecules mediating resistance to immune checkpoint inhibitors in individual cHL patients, thereby favoring the implementation of personalized therapies.
Association of the prognostic nutritional index and overall survival in patients with colorectal cancer: A STROBE compliant retrospective cohort study
Authors: Luvián‐Morales Julissa , González‐Trejo Sagrario , Carrillo José F. , Herrera‐Goepfert Roberto , Aiello‐Crocifoglio Vincenzo , Gallardo‐Rincón Dolores , Ochoa‐Carrillo Francisco J. , Oñate‐Ocaña Luis F. 
Published: May 2019

AbstractBackgroundThe TNM classification does not completely reflect the prognosis of patients with colorectal cancer (CRC). Several clinical factors have been used to increase its prognostic value, but factors pertaining to the patient's immunonutritional status have not usually been addressed. The aim of this study is to evaluate the role of Prognostic nutritional index (PNI) and other well‐known prognostic factors by multivariate analysis in a cohort of patients with CRC.MethodsThis is a retrospective cohort study of consecutive patients with CRC managed in a cancer center between January 1992 and December 2016. Cox's model was used to define the association of the PNI and other factors with Overall survival (OS).ResultsA total of 3301 patients were included: 47.7% were female and 52.3% were male, with a mean age of 58.7 years. By bivariate analysis, PNI was strongly associated with OS (Risk ratio [RR] 0.968, 95% Confidence interval [CI] 0.962‐0.974; P < 0.001). On multivariate analysis, PNI was an independent explanatory variable (as continuous variable and as categorized variable; RR 0.732, 95% CI 0.611‐0.878; RR 0.656, 95% CI 0.529‐0.813 and RR 0.646, 95% CI 0.521‐0.802, for quintiles 2, 3, and 4‐5, respectively); a biological gradient effect was demonstrated. The final prognostic model included PNI, location of the neoplasia in the colorectum, basal hemoglobin, lymphocyte count, neutrophil/lymphocyte ratio, platelet/lymphocyte ratio, TNM stage, differentiation degree, R classification, and postoperative complications.ConclusionsPNI is a significant and independent prognostic factor in patients with CRC. Its prognostic value adds precision to the TNM staging system including specific subgroups of patients with CRC; it should be evaluated in prospective clinical studies.
Control of a Hybrid Energy Storage System for a Hybrid Compensation System
Authors: Böhm Ralf , Steglich Michael , Rehtanz Christian , Paulsburg Martin , Datsevic Sergey , Brunner Benjamin , Franke Jörg 
Published: May 2019

AbstractThe combination of two or more different energy storage technologies in a hybrid energy storage system appears to be advantageous if the combination of technologies fulfils the storage purpose better than a single storage technology. Herein, requirements regarding the performance of the storage system are determined for a hybrid compensation system for provision of system services in medium‐voltage grids. In hybrid storage systems, a common control system ensures that the present storage technologies are utilized in such a way that total storage efficiency is highest and that usability of the application is maximized. The control system of a hybrid storage system consisting of a redox flow battery and high‐speed flywheel storage is introduced and evaluated.
Improving Energy Performance Indicators with the Help of Multivariable Linear Regression
Authors: Mutschler-Burghard Rainer 
Published: May 2019

AbstractCompanies with energy management systems face difficulties in practice to determine an improvement in energy efficiency in a way that can be verified. This is due to a variety of influences on energy consumption, such as differing product portfolios, rising production volumes, and climatic influences. With the aid of multivariable linear regression analysis, the relationship between a company's electricity consumption and potential influencing factors is examined step by step. The result is a mathematical formula that is at once the energy‐related baseline and the new energy performance indicator (EnPI) for electricity as an energy source.
Electrochemical Synthesis of 3‐Bromoimidazo[1,2‐a]pyridines Directly from 2‐Aminopyridines and alpha‐Bromoketones
Authors: Jian Wen‐Qian , Wang Hai‐Bin , Du Ke‐Si , Zhong Wei‐Qiang , Huang Jing‐Mei 
Published: May 2019

AbstractA highly efficient co‐electrolysis of 3‐bromoimidazo[1,2‐a]pyridines has been developed in a simple undivided cell without any external oxidant. This protocol proceeds smoothly to provide the products with a broad substrate scope through a domino condensation/bromination sequence. Importantly, it can be easily scaled up.
Tuning Electron Transport Direction through the Deposition Sequence of MoS2 and WS2 on Fluorine‐Doped Tin Oxide for Improved Electrocatalytic Reduction Efficiency
Authors: Liu Yajuan , Yin Jie , Zhou Yuqing , Sun Luo , Yue Wenjin , Sun Yueming , Wang Yuqiao 
Published: May 2019

AbstractMoS2−WS2 films on fluorine‐doped tin oxide (FTO) can be vulcanized through chemical vapor deposition by using MoO3 and WO3 as precursors prepared by pulsed laser deposition. The electron transport direction can be tuned by the deposition sequence of metal sulfides on FTO, owing to the differences in the conduction bands (CBs, MoS2 −4.38 vs. WS2 −4.13 eV), defined as the energy level impedance to adjust the electron transport rate. It means that the electron transport rate from FTO to the MoS2 surface of FTO/WS2/MoS2 might be higher than the rate from FTO to the WS2 surface of FTO/MoS2/WS2. The assumption was verified by the electrocatalytic reduction of I3− to I− using the above films as a counter electrode in a dye‐sensitized solar cell. The short‐circuit photocurrent density of FTO/WS2/MoS2 achieved 14.16 mA cm−2, which is superior to FTO/MoS2/WS2 (11.72 mA cm−2), indicating that the catalytic activity of FTO/WS2/MoS2 was higher than that of FTO/MoS2/WS2. The electron transport direction can be successfully regulated by tuning the deposition order.