bluuebunny/crossref_metadata_2025_split huggingface dataset:
THE MEASUREMENTS OF BLOOD CLOTTING IN CARDIORENAL SYNDROME IN ELDERLY
Authors: Naumov Ya. A. , Shevchenko O. P. , Orlova I. Ju. , Faradzhov R. A.o. , Naumova N. A. 
Published: July 2018

Aim. To assess the changes in hemocoagulation parameters according to the grade of renal dysfunction in elderly patients with cardiorenal syndrome types II and IV.Material and methods. In 56 patients of the elderly age group (mean age 78±10 y.o.), with coronary heart disease and chronic heart failure, the parameters of blood clotting were assessed and the relations with kidney dysfunction grade measured by the level of glomerular filtration rate (GFR). Patients were selected to 3 groups. In 47 (83,9%) there was decline of GFR <60 mL/min/1,73 m2, of those in 8 (17,3%) <30 mL/min/1,73 m2; in 9 GFR >60 mL/min/1,73 m2, with no signs of proteinuria (16,1%). All patients underwent coagulological assessment of the blood with measurement of the activated partial thromboplastin time, thrombin time and prothrombin time, international normalized ratio and fibrinogen concentration, as the complete blood count with platelet number, mean platelet volume, thrombocyte distribution width, and thrombocrit.Results. The number of platelets did differ significantly in groups 1 and 3 (p=0,040), as 2 and 3 (p=0,007). Thrombocrit values did differ significantly only in 2 and 3 (p=0,029). In the group 3 the rate of the mentioned values was below the respective reference values. Fibrinogen levels did differ significantly in groups 1 and 3 (p=0,042), and 2 and 3 (p=0,037). In the group 3 the parameter was higher than upper limit of reference range. Correlation found for GFR and fibrinogen level (r=-0,425; p=0,004), for GFR and platelet number (r=0,271; p=0,049). The platelet number correlated with creatinine level (ρ=-0,392; p=0,004). Creatinine level also correlated with fibrinogen level (ρ=0,375; p=0,012).Conclusion. In the elderly, with the decline of GFR there is decline of thrombocyte number and increase of fibrinogen concentration together with an increase of the severity of kidney dysfunction. The pathological changes that were found might probably serve as additional factor influencing the risk of adverse events related to disorder of blood clotting. The importance of the revealed relations, as the aimfulness for clinical application, should be evaluated in controlled studies.
Human Rights Norm Diffusion in Southeast Asia
Authors: Netipatalachoochote Stanati , Holzhacker Prof.Dr. Ronald , Ciacchi Prof.Dr. Aurelia Colombi 
Published: July 2018

Abstract
Civil Society Organizations (CSOs) have played an increasingly vocal role in their struggle to advance both human rights protection and promotion in Southeast Asian countries. Most notably, CSOs have become a more important actor in dealing with human rights issues in particular by virtue of their role in drawing attention to human rights violations. In the case of massive human rights violations happening in Southeast Asia, CSOs pursue various strategies to address and try to end such abuses. Spreading information of human rights violations occurring in each member state to regional peers, and then finding new allies such as international organizations to put pressure back to human rights-violating states, in what is characterized as a dynamic of the boomerang model, one of the prominent strategies CSOs use to relieve human rights violations. Another strategy recently observed involves CSOs reaching out to powerful judicial institutions whose decisions can be legally binding on a violating state. Spreding This paper applies the boomerang model theory to the efforts of CSOs, specifically with respect to their work in helping to end the extrajudicial killing of drug dealers in the Philippines during President Duterte’s tenure, to display how the dynamics of the boomerang model works and what this strategy has achieved in terms of ending the extrajudicial killings. Beyond the boomerang model, this paper further demonstrates the strategy of CSOs in reaching out directly to powerful judicial institutions, in this case the International Criminal Court (ICC). The paper discusses why CSOs pursued this strategy of reaching out to the ICC, bypassing the region’s human rights institution—the ASEAN Intergovernmental Commission on Human Rights (AICHR).
Keywords: Civil Society Organizations (CSOs); Extrajudicial Killing in the Philippines; The International Criminal Court (ICC).
(A previous version of this paper was presented at the 14th Asian Law Institute (ASLI) Conference hosted by the University of Philippines, College of Law (UP) in 19 May 2017. We would like to thank the commentators and the audience for their questions and comments on the paper.)
Development of Model on Mothers Self-Efficacy in Preventing Recurrence of Non-Pneumonia Acute Respiratory Infection among Toddlers
Authors: Zatihulwani Eliza Zihni , Sukartini Tintin , Krisnana Ilya 
Published: July 2018

Introduction: Acute Respiratory Infection (ARI) is the leading cause of morbidity and mortality in children. A cough and cold diseases such as rhinitis, pharyngitis, tonsillitis and other upper respiratory diseases are classified as non-pneumonia. ARIs that are not appropriately handled will affect the lung tissue and cause severity and even death. The purpose of this study is to develop a model of self-efficacy (SE) among mother to prevent recurrent (PR) non pneumonia (NP)-ARI on toddlers based on the integration of Precede-Proceed Model and Health Belief Model.Method: This study used cross-sectional design. The population were a mother with a toddler in Tanggalrejo Village of Mojoagung Jombang. A hundred toddler’s mothers were recruited as samples by cluster sampling. Variables in this study were predisposing-enabling-reinforcing factors, main constructs of perceived (MCP), perceived threat, SE and PRNP-ARI. Data were collected using questionnaire, and Focus Group Discussion then analyzed using Partial Least Square (PLS).Results: The SE improvement model for the PRNP-ARI was formed from predisposing-enabling-reinforcing factors, MCP, perceived threat, and maternal SE. The greatest effect was on MCP against a perceived threat with T statistic value = 11.07.Conclusion: Increasing SE of toddler's mother can be done by educating mother about ARI concept, conventional ARI treatment, environmental modification, benefits of mask use, clean and healthy life behavior, proper hand washing, nutrition feeding, exclusive breastfeeding, stress management; create peer support group for toddlers mother; and optimizing the role of health officers and family support.
AKTUALISASI SIKAP KEAGAMAAN DALAM RANAH SOSIAL (Rekonstruksi Peran IPS dalam Pengembangan Sikap Keagamaan)
Authors: Farisi Mohammad Imam 
Published: July 2018

<p><strong>: </strong>Dalam sejarah pendidikan di Indonesia, setidaknya telah terjadi delapan kali perubahan kurikulum, diantaranya adalah kurikulum 2013 (K-13) yang sekaligus merupakan kurikulum pertama yang memiliki dasar-dasar pemikiran yang progresif. Ini terkait dengan penggunaan filsafat Rekonstruksionisme Sosial dan teori Gestalt sebagai landasan pengembangannya. Atas dasar kedua teori-filsafat itu pula, Kurikulum 2013 mampu mewahanai prinsip keterpaduan, keutuhan, atau integralitas antar-konten atau isi kurikulum; antara konten kurikulum dengan realitas kehidupan; dan berorientasi pada pembentukan pengetahuan, sikap, dan keterampilan fungsional secara terintegrasi. Termasuk integrasi kajian keagamaan di dalam semua mata pelajaran di sekolah. Tulisan ini mengkaji dan mendeskripsikan dimensi-dimensi sikap keagamaan dalam kurikulum 2013, baik dalam mata pelajaran Pendidikan Agama, maupun mata-mata pelajaran lain; integrasi kompetensi sikap keagamaan dalam IPS; dan model pengorganisasian pembelajaran IPS-Tematik dalam rangka pembentukan dan aktualisasi sikap keagamaan dalam realitas kehidupan bermasyarakat, berbangsa, dan bernegara.</p><p> </p><p><strong>Kata kunci: </strong>abstrak, esensi penelitian, mesin pencari.</p>
PENGEMBANGAN MEDIA OTAK KATA TEMA PERTANIAN BAGI SISWA KELAS III SEKOLAH DASAR
Authors: Murdhiyaningsih Titik , Reffiane Fine , Purnamasari Iin 
Published: July 2018

<div class="WordSection1"><p>Penelitian ini dilatarbelakangi oleh pembelajaran yang masih cenderung menggunakan metode ceramah. Berdasarkan analisis kebutuhan pada tujuh sekolah be­lum menyediakan media dan sangat membutuhkan media. Tujuan dari penelitian ini adalah mengetahui validitas Media Otak Kata (MEDOKA) dan, mengetahui kepraktisan penggunaan Media Otak Kata (MEDOKA) pada Tema Pertanian kelas III Sekolah Dasar. Subjek penelitian ini adalah Kelas III SD Negeri Ngablak 0l se­bagai kelas uji coba produk dengan jumlah siswa 30 menggunakan kelompok besar dan kelompok kecil, serta Kelas III SD Negeri Ngablak 02 sebagai kelas uji coba produk dengan jumlah siswa 17. Metode penelitian yang digunakan adalah Research and Development atau penelitian pengembangan menggunakan <em>ADDIE</em> (<em>Analysis, Design, Development, Implementation, and Evaluation).</em><em> </em>Hasil analisis pada validasi ahli materi 86,7%, dua ahli media 98,3% , angket tanggapan SD Negeri Ngablak 01 88,46%, SD Negeri Ngablak 02 69,29%, angket guru SD Negeri Ngablak 01 86,6% dan SD Negeri Ngablak 02 69,23%. Menunjukkan MEDOKA valid dan praktis dalam tema pertanian materi energi.<em> </em>Kesimpulan penelitian ini adalah pengembangan MEDOKA praktis dan valid sebagai motivasi, minat, dan keefektifan belajar siswa SD Kelas III. MEDOKA digunakan untuk media pembelajaran yang baru.</p><p> <strong>Kata Kunci:</strong> R&amp;D; <em>ADDIE</em>; MEDOKA, pertanian</p><p><strong> </strong></p></div><p><strong><br clear="all" /></strong></p>
PENGARUH MEDIA PEMBELAJARAN CORONG HITUNG TERHADAP HASIL BELAJAR SISWA DALAM MATERI PERKALIAN
Authors: Widi astuti Endah Yuli 
Published: July 2018

<p>Tujuan penelitian ini untuk mengetahui penggunaan Media Pembelajaran Corong Hitung berpengaruh terhadap hasil belajar siswa. Jenis penelitian ini adalah eksperimen, Populasi dalam penelitian ini adalah seluruh siswa kelas II SDN Jatiroto 01 Kayen. Sampel dalam penelitian ini adalah kelas II yang berjumlah 20 siswa dengan menggunakan sampel jenuh. Desain penelitian eksperimen menggunakan <em>Pre Experimental Design</em> yang digunakan adalah <em>One Group</em> <em>Pretest-Posttest Design</em>. Berdasarkan hasil analisis data normalitas tahap awal <em>pretest </em>diperoleh L<sub>0 </sub>= 0,129 &lt; L<sub>tabel </sub>= 0,190 maka H<sub>0</sub> diterima dan data berasal dari distribusi normal. Begitupula dengan hasil analisis data normalitas tahap akhir <em>posttest </em>diperoleh L<sub>0 </sub>= 0,140 &lt; L<sub>tabel </sub>= 0,190 maka H<sub>0</sub> diterima dan data berasal dari distribusi normal. Selanjutnya perhi­tungan uji t terhadap hasil belajar diperoleh t <sub>hitung </sub> = 9,372 &gt; t <sub>tabel </sub>= 1,729. Maka H<sub>i</sub> diterima. Hal ini berarti hasil belajar Matematika Siswa kelas II SDN Jatiroto 01 Kayen mencapai KKM 65 dan hasil perhitungan ketuntasan belajar siswa di kelas mencapai 85 %. Media Pembelajaran Corong Hitung berpengaruh terhadap hasil bela­jar Matematika materi Perkalian siswa kelas II SDN Jatiroto 01.</p><p> </p><p>Kata kunci : media pembelajaran corong hitung, hasil belajar matmatika</p>
Navigating Unchartered Waters: A Nursing Perspective on Lewy Body Dementia
Authors: Rañola Madelaine B 
Published: July 2018

Abstract
Although Lewy body dementia (LBD) is the second most common form of dementia to Alzheimer’s disease, this more rapidly progressive neurodegenerative disorder remains largely unknown to the public and is under-recognised by health care professionals.
Early and accurate diagnosis is complicated by many different presentations of the disease which can include a mixture of clinical features seen in both Alzheimer’s disease (AD) and Parkinson’s disease (PD). Motor and cognitive dysfunction as well as behavioural and mood disturbance are common overlapping features. What sets LBD apart however, is the variability and unpredictability of the disease and sensitivity to conventional anti-psychotic medications
The ambiguous nature of LBD places significant stress on caregivers and presents unique challenges for the long-term clinical management of the disease. This paper is aimed at raising awareness of LBD and proposing key nursing interventions to enhance both quality and length of life.
The impact of functional vision changes on independent travel for individuals with adult-onset visual impairment
Authors: Avila Kimberly 
Published: July 2018

Abstract
This study explored experiences with functional vision changes resulting from adult-onset vision conditions. The impact of glare, light-to-dark adaptation, depth perception, night blindness, and contrast sensitivity are examined for the way participants perceive their effects on willingness to engage in independent travel.
Two interviews were conducted with 13 participants. These consisted of structured and semi-structured, open-ended questions to determine the impact of functional vision changes on mobility and pedestrian travel. Qualitative, open and a priori coding was used to derive themes and categories for the most significant functional vision considerations among participants.
This study revealed changes in functional vision impact participants’ perceived safety and were of concern when considering independent travel. Orientation and mobility (O&M) services were denied to some participants who had surrendered driving privileges and were considered vision impaired, but not legally blind, even though issues with functional vision impacted safer travel.
The impact of functional vision changes on individuals with adult-onset vision impairment was found to affect participant mobility. Agencies serving this population can provide clients with safer travel options when all functional vision changes are considered beyond acuity and field of vision loss.
Sero-epidemiology and Risk Factor Analysis of Measles Among Children in Pakistan
Authors: RASOOL MUHAMMAD HIDAYAT , RAFIQ AHSAN , NAWAZ MUHAMMAD ZEESHAN , SHAFIQUE MUHAMMAD , SAQALEIN MUHAMMAD 
Published: July 2018

Abstract
Comparative cross sectional study was conducted on blood samples (n = 231) collected from children of 1 to 10 years of age in Punjab Pakistan through convenient sampling method. Indirect haemagglutination assay (IHA) was standardized and used for serodiagnosis and evaluation of humoral immunity against measles. Associated risk factors including age, gender, locale, and vaccination status were analyzed. Geometric mean titre (GMT) of vaccinated individuals was significantly higher (p < 0.001) than that of non-vaccinated individuals showing that IHA titre of vaccinated individuals was a measure of humoral immune response; whereas, in case of non-vaccinated individuals an indicative of exposure to the measles infection.
Brucella – Virulence Factors, Pathogenesis and Treatment
Authors: GŁOWACKA PATRYCJA , ŻAKOWSKA DOROTA , NAYLOR KATARZYNA , NIEMCEWICZ MARCIN , BIELAWSKA-DRÓZD AGATA 
Published: July 2018

Abstract

Brucellae are Gram-negative, small rods infecting mammals and capable of causing disease called brucellosis. The infection results in abortion and sterility in domestic animals (sheeps, pigs, rams etc). Especially dangerous for humans are: Brucella melitensis, Brucella suis, Brucella abortus, and Brucella canis that trigger unspecific symptoms (flu-like manifestation). Brucella rods are introduced via host cells, by inhalation, skin abrasions, ingestion or mucosal membranes. The most important feature of Brucella is the ability to survive and multiply within both phagocytic and non-phagocytic cells. Brucella does not produce classical virulence factors: exotoxin, cytolisins, exoenzymes, plasmids, fimbria, and drug resistant forms. Major virulence factors are: lipopolysaccharide (LPS), T4SS secretion system and BvrR/BvrS system, which allow interaction with host cell surface, formation of an early, late BCV (Brucella Containing Vacuole) and interaction with endoplasmic reticulum (ER) when the bacteria multiply. The treatment of brucellosis is based on two-drug therapy, the most common combinations of antibiotics are: doxycycline with rifampicin or fluoroquinolones with rifampicin. Currently, also other methods are used to disrupt Brucella intracellular replication (tauroursodeoxycholic acid or ginseng saponin fraction A).
Long-term outcome of children with autism who received different forms of early intervention during their preschool years: a pilot study of 15 young adults
Authors: Jónsdóttir Sigrídur Lóa , Brynjarsdóttir Birta , Saemundsen Evald , Sigurdsson Jón Fridrik 
Published: July 2018

Abstract
Background: Studies on early intervention have reported significant gains for many children with autism. Knowledge on how these children fare in adulthood is limited.
Objective: To examine long-term outcome of children with autism who received different forms of early intervention.
Method: Participants were 15 young people who had all been diagnosed with ICD-10 childhood autism during the preschool years. Five received intervention based on the UCLA model for early intensive behavioral intervention, and 10 received eclectic treatment. Participants were followed from their first autism diagnosis during the preschool years (time 1) to the age of six years (time 2). The participants are now in their twenties (time 3), and at this point in time, information on autism symptoms, co-occurring disorders, quality of life, functioning, participation, adaptive behavior, and overall outcome was gathered from parents. Six of the participants answered questionnaires on quality of life, functioning, and participation.
Results: The groups were comparable on all measures at time 1. Reassessment at time 2 showed that the early intensive behavioral intervention group had made significant gains in IQ, and that autism symptoms had decreased significantly, whereas such changes were not found for the eclectic treatment group. At time 3, most participants had considerable autism symptoms. Approximately half of them had received diagnosis of a co-occurring condition. Their quality of life and adaptive behavior was less favorable than that of the general population, but only a third had “poor” overall outcome. However, at time 3, hardly any differences were found between the groups.
Conclusions: To maintain gains made during the preschool years, appropriate intervention and services may need to be extended into adulthood. These services should take into account the perceived needs of the individual, as expressed by himself/herself and his/her family.
CHITIN- AND CHITOSAN BIOSORBENTS FROM CITRIC A CID MYCELIAL INDUSTRIAL WASTE
Authors: Novinyuk L. V. , Kulyov D. K. , Negrutsa I. V. , Velinzon P. Z. 
Published: July 2018

The goal of this study is to examine sorption capacity of chitin-glucan (ChGC) and chitosan-glucan (CsGC) biopolymer complexes extracted from the fungus Aspergillus niger mycelium. According to the findings chitosanglucan complex sorbs lead and copper ions (130–140 mg/g) better than chitin-glucan complex (50–80 ex mg/g). Langmuir theoretical model with R2= 0,996 determination coefficient well describe sorption isotherms. It is shown the chelate complex formation compound character based on ion and coordination bonds by chitin and chitosan biopolymers is more complex. According to test results the production of chitin and chitosan containing biopolymers from citric acid production mycelium by-products has a good future. The above biopolymers have a functional use. Besides of that they sorbs heavy metals and radionuclide ions.
Adsorption of Antimonate, Sulfate, and Phosphate by Goethite: Reversibility and Competitive Effects
Authors: Essington Michael E. , Stewart Melanie A. 
Published: July 2018

Core Ideas
Sb(V) adsorption by goethite decreases with increasing pH and is unaffected by ionic strength.
Sb(V) adsorption is hysteretic.
Adsorbed Sb(V) generates a downward shift in the goethite isoelectric point.
The adsorption of Sb(V) decreases in the presence of phosphate, but is unaffected by sulfate.
Inner sphere mono‐ and bidentate Sb(V) complexation by goethite is predicted.
Goethite is a sink for antimonate Sb(OH)6– [Sb(V)] in soil and sediments. The pH‐ and ionic strength (I)‐dependent mass distribution of Sb(V) between adsorbed and solution phases at equilibrium may be used to indirectly infer an adsorption mechanism (inner vs. outer sphere surface complexation) and to develop predictive surface complexation models. The objectives of this study were to characterize the adsorption of Sb(V) by goethite as a function of pH, I, and in the absence or presence of competing ligands, SO4 or PO4. Ligand adsorption was at a maximum in strongly acidic suspensions and decreased with increasing pH. Adsorption envelopes of Sb(V) where not influenced by I, but increasing I decreased SO4 and increased PO4 retention. In strongly acidic suspensions, SO4 and PO4 retention was not influenced by I. Ligand adsorption decreased the isoelectric point (IEP) of goethite from 8.5 to 6.3 [Sb(V)] and 4 (PO4). The adsorption of SO4 did not affect the IEP, although SO4 reduced the zeta potential of goethite when pH < IEP. Antimonate and PO4 adsorption was hysteretic; SO4 adsorption was reversible. Sulfate did not impact Sb(V) retention; adsorbed Sb(V) generated greater negative surface charge, decreasing SO4 adsorption. Both Sb(V) and PO4 competed for adsorption sites, resulted in reduced retention of both in competitive systems. The triple layer formulation of the charge distribution multisite complexation model, coupled with inner sphere surface complexation, was used to describe the adsorption envelopes for Sb(V), SO4, and PO4, and to predict adsorption in competitive systems.
Theoretical Coupling and Stability of Boronic Acid Adducts with Catecholamines
Authors: Demianenko Eugeniy , Rayevsky Alexey , Soriano-Ursúa Marvin A. , Trujillo-Ferrara José G. 
Published: July 2018

Background:
Catecholamines combined with boric/boronic acids are attractive chemical
agents in drug design because some of their adducts have shown interesting biological activity.
Scant information exists about their stability.

Objective:
The aim of the present theoretical study was to explore the role of boron in molecules
that combine catecholamines and boric/boronic acids, with a particular interest in examining
stability.

Method:
The methodology was based on the US GAMESS program using DFT with the B3LYP
exchange-correlation functional and the 6-31G (d,p) split-valence basis set.

Results:
According to the current findings, the boron-containing compounds (BCCs) exhibit weaker
bonding to the hydroxyls on the ethylamine moiety than to those in the aromatic ring. The strongest
binding site of a hydroxyl group was often found to be in meta-position (relative to ethylamine
moiety) for boron-free compounds and in para-position for BCCs. Nonetheless, the methyl substituent
in the amino group was able to induce changes in this pattern. We analyzed feasible boronsubstituted
structures and assessed the relative strength of the respective C-B bonds, which allowed
for the identification of the favorable points for reaction and stability.

Conclusion:
It is feasible to form adducts by bonding on the amine and catechol sides of catecholamines.
The presence of boron stabilizes the adducts in para-position. Since some of these BCCs
are promising therapeutic agents, understanding the mechanisms of reaction is relevant for drug
design.