bluuebunny/crossref_metadata_2025_split huggingface dataset:
Difference of Right Ventricular Systolic Function Before and After Hemodialysis in Chronic Kidney Disease Stage V In RSD dr. Soebandi Jember
Authors: Mediawati Saskia , Suryono Suryono , Suswati Enny 
Published: February 2019

End stage renal disease is a clinical state with an irreversible chronic decreasing function of renal that need a hemodialysis or renal transplant as theraphy. One of the complication of End stage renal disease is cardiovascular. Cardiovascular complication is a major cause of mortality and mobility in End stage renal disease by 44% in Indonesia. Systolic function of right ventricle can be used to assess the heart function. The purpose of this study is to differentiate the systolic function of right ventricle in patient with end stage renal disease in RSD dr. Soebandi Jember. We used analytical observational approach with cross sectional method held at Dialysis and Echocardiography Unit of RSD dr. Soebandi Jember from September to November 2017. Thirty patients with end stage renal disease who routinely undergoes dialysis were observed. Shapiro-Wilk test results 0,000 significance shows that the data is not normally distribute. Wilcoxon test results significance level 0,005 which shows there is a differentiation between before and after hemodialysis of systolic function in end stage renal disease patients of RSD dr. Soebandi Jember.
Keywords : End stage renal disease, systolic function on right ventricle, hemodialysis
The Correlation between HIV/AIDS Positive Pregnant Mother with Infant APGAR Score in RSD dr. Soebandi Jember
Authors: Purwaningsih Nurlaila Ayu , Shodikin Muhammad Ali , Abrori Cholis 
Published: February 2019

Human Immunodeficiency Virus (HIV) is a virus that decreased immunity and a set symptoms of diseases called Acquired Immune Deficiency Syndrome (AIDS). One of the major risk factors for HIV transmission is perinatal transmission about 2.8% during pregnancy, delivery, and postpartum. HIV positive mothers have a potential to give birth infants with low APGAR. APGAR Score was used as a reference to determine asphyxia in the first and fifth minutes of life. The purpose of this research were to determine the correlation between HIV/AIDS positive pregnant mother with infant APGAR Score and to determine the other factors that affect the infant APGAR Score in RSD dr. Soebandi Jember. This research used observational analytic survey method with cross sectional design using medical record of HIV positive and negative pregnant women from August 2014-July 2017 in RSD dr. Soebandi Jember as a subject that qualify the inclusion and exclusion criteria. This research used case group sampling technique by total sampling and control group by simple random sampling each 52 samples. Test result of the correlation between HIV/AIDS positive pregnant mother with infant APGAR Score using Chi-Square test obtained p value=1.000 (OR=1.13) that means there was no significant correlation. Test result of the correlation between the other factors that affect infant APGAR Score concluded that there were no significant correlation.
Keywords: pregnant mother, HIV/AIDS, APGAR Score, infant
The Difference of Plasma Malondialdehyde (MDA) Level in Farmers Using Chemical Pesticides and Farmers Using Organic Pesticides
Authors: Nur Rahmadani Nikmatul Maula , Rachmawati Dwita Aryadina , Elfiah Ulfa 
Published: February 2019

Many farmers still use chemical pesticides. Chemical pesticides inside the body will form free radicals that will bind to unsaturated fatty acids (cell membrane structures) that cause increased levels of malondialdehyde (MDA). Organic pesticides can be used as an alternative to control pests. Organic pesticides leave no residues to plants and the environment. This study aims to determine the difference of plasma malondialdehid (MDA) levels in farmers who use chemical pesticides in Dawuhan Village, Tenggarang Subdistrict, Bondowoso Regency and farmers who use organic pesticides in Lombok Kulon Village, Wonosari Sub-district, Bondowoso District. This was an observational analytic research with cross sectional research design conducted on 30 farmers who use chemical pesticides and 30 farmers who use organic pesticides. Blood sampling was taken from Mediana cubiti vein. Measurements of plasma malondialdehyde (MDA) were performed using the TBARS method. Based on the result of Unpaired T-test, it was found that p < 0.001 which showed significant difference in plasma malondialdehyde (MDA) level in farmers using chemical pesticides and farmers using organic pesticides. The plasma malondialdehyde (MDA) level average were higher in farmers using chemical pesticides.
Keywords: Chemical Pesticide, Organic Pesticide, Plasma Malondialdehyde
The Influence Of Using Extract Neem Leaf (Azadirachta indica A.juss) Soap In The Scabies lesions grade II Healing
Authors: Murniati Anis , Rohmawati Indah 
Published: February 2019

Scabies is an infectious skin disease caused by infection with Sarcoptes scabiei mites. Clinical symptoms of itching in the lesions. There are herbal plants, namely the neem plant with the content of mimba leaf extract, giving a very good effect in providing resistance to mites in vitro. Mimba leaf processing can be done to make various products, including soap products. So the researchers wanted to develop the concept and knowledge of the effects of soap made from mimba leaf extract in curing lesions in scabies grade II patients in the female dormitory of Ponpes Pandanaran Ngunut Tulungagung. This study uses the Quasy Experiment design with an experimental design of Non equivalent control group design. The treatment group was divided into two treatment groups, namely the treatment using neem leaf extract soap (Azadirachta indica A. juss) and using antibacterial soap. The sample was determined using purposive sampling according to the inclusion criteria, as many as 70 respondents. The assessment used observation sheets of lesion wounds according to the modified Bates-jensen wound assessment tool. The results of the analysis of 70 respondents obtained the results of independent t-test statistics obtained a significance value of p (value) = 0,000. The use of solid soap mimba leaf extract (Azadirachta indica A. juss) in dealing with scabies with Azadirachtinya content which is able to provide resistance to mites by inhibiting the life cycle (metamorphosis).
Keywords: Scabies, neem leaves, lesions, healing
CommunityRx: A Real-World Controlled Clinical Trial of a Scalable, Low-Intensity Community Resource Referral Intervention
Authors: Lindau Stacy Tessler , Makelarski Jennifer A. , Abramsohn Emily M. , Beiser David G. , Boyd Kelly , Chou Chiahung , Giurcanu Mihai , Huang Elbert S. , Liao Chuanhong , Schumm L. Philip , Tung Elizabeth L. 
Published: February 2019

Objectives. To test the effect of CommunityRx, a scalable, low-intensity intervention that matches patients to community resources, on mental health-related quality of life (HRQOL) (primary outcome), physical HRQOL, and confidence in finding resources. Methods. A real-world trial assigned publicly insured residents of Chicago, Illinois, aged 45 to 74 years to an intervention (n = 209) or control (n = 202) group by alternating calendar week, December 2015 to August 2016. Intervention group participants received usual care and an electronic medical record–generated, personalized list of community resources. Surveys (baseline, 1-week, 1- and 3-months) measured HRQOL and confidence in finding community resources to manage health. Results. At 3 months, there was no difference between groups in mental (–1.03; 95% confidence interval [CI] = −3.02, 0.96) or physical HRQOL (0.59; 95% CI = −0.98, 2.16). Confidence in finding resources was higher in the intervention group (odds ratio = 2.08; 95% CI = 1.18, 3.63); the effect increased at each successive time point. Among intervention group participants, 65% recalled receiving the intervention; 48% shared community resource information with others. Conclusions. CommunityRx did not increase HRQOL, but its positive effect on confidence in finding resources for self-care suggests that this low-intensity intervention may have a role in population health promotion. Trial Registration. ClinicalTrials.gov Identifier: NCT02435511.
Ethical Acceptability of Reducing the Legal Blood Alcohol Concentration Limit to 0.05
Authors: Morain Stephanie , Largent Emily 
Published: February 2019

Twenty-nine Americans die in alcohol-impaired driving crashes daily. The National Academies of Sciences, Engineering, and Medicine released a report that identified strategies to reduce alcohol-impaired driving deaths. One strategy suggests amending state laws to reduce the legal blood alcohol concentration (BAC) limit from 0.08 to 0.05.Although BAC 0.05 laws would likely reduce alcohol-related deaths, they are also controversial. Critics object to these laws because they restrict individual liberty and fail to consider that individuals value social drinking.We explored the ethical acceptability of BAC 0.05 laws. We made an ethical argument in support of BAC 0.05 laws, which include preventing harm to both drinking drivers and to others. We then considered and rejected liberty-based objections to BAC 0.05 laws. We concluded that BAC 0.05 laws are not only ethically defensible but desirable. States and Congress should work to promote them.
Identifying Chicago’s High Users of Police-Involved Emergency Services
Authors: Tentner Andrea Ruth , Spellman Amy , Paulson Allison , Day Cameron , Sadler Tonie , Coffman Ruth , Pollack Harold A. 
Published: February 2019

Objectives. To identify individuals at risk for behavioral health (BH)–involved encounters with police in Chicago, Illinois. Methods. We linked Chicago Police Department (CPD) arrest and Fire Department (CFD) BH-involved ambulance event data. We identified at-risk individuals who accumulated at least 1 BH-involved ambulance and at least 1 arrest event between May 2016 and April 2017. We identified a high-use subgroup displaying most intensive services use. We identified high-use locations with highest volume of ambulance events with only CFD data. Results. Of 83 392 individuals and 116 105 events in the linked emergency events data, 1842 at-risk individuals accounted for 2.2% of individuals, 5.6% of all events, and 16% of BH-involved CFD events with police involvement. A total of 330 high-use individuals accounted for 0.4% of individuals, 2% of events, and 4.7% of CFD events with police involvement. Top-100 high-use locations accounted for 9% of CFD events, and individuals of high-use location events are largely distinct from high-use individuals. Conclusions. Integrated police and ambulance data hold promise to identify individuals at risk for BH-involved encounters with police and to support proactive interventions to prevent or improve response at these encounters.
Paradoxical Impact of a Patient-Handling Intervention on Injury Rate Disparity Among Hospital Workers
Authors: Sabbath Erika L. , Yang Jie , Dennerlein Jack T. , Boden Leslie I. , Hashimoto Dean , Sorensen Glorian 
Published: February 2019

Objectives. To test whether a comprehensive safe patient-handling intervention, which successfully reduced overall injury rates among hospital workers in a prior study, was differentially effective for higher-wage workers (nurses) versus low-wage workers (patient care associates [PCAs]). Methods. Data were from a cohort of nurses and PCAs at 2 large hospitals in Boston, Massachusetts. One hospital received the intervention in 2013; the other did not. Using longitudinal survey data from 2012 and 2014 plus longitudinal administrative injury and payroll data, we tested for socioeconomic differences in changes in self-reported safe patient-handling practices, and for socioeconomic differences in changes in injury rates using administrative data. Results. After the intervention, improvements in self-reported patient-handling practices were equivalent for PCAs and for nurses. However, in administrative data, lifting and exertion injuries decreased among nurses (rate ratio [RR] = 0.64; 95% confidence interval [CI] = 0.41, 1.00) but not PCAs (RR = 1.10; 95% CI = 0.74,1.63; P for occupation × intervention interaction = 0.02). Conclusions. Although the population-level injury rate decreased after the intervention, most improvements were among higher-wage workers, widening the socioeconomic gap in injury and exemplifying the inequality paradox. Results have implications for public health intervention development, implementation, and analysis.
The Mobilization of Splenic Reservoir Myeloid-Derived Suppressor Cells in Sepsis-Induced Myocardial Injury
Authors: Fu Cong , Xu Qiancheng , Tang Shengxing , Cao Yuhan , Liu Can , Li Juan , Wang Yihua , Qian Yan , Shi Fei , Gui Jingmin , Fan Qun , Ling Yang 
Published: February 2019

Abstract
Background

Myeloid-derived suppressor cells (MDSCs) play key roles in sepsis, but whether bone marrow is considered the only source remains unclear. The current knowledge about the mechanism of MDSCs leading to myocardial injury in sepsis is poor.

Methods

In sepsis patients with cardiac dysfunction, the circulating percentage of CD14-CD11b+ and serum concentrations of IL-6 and IL-1β were measured. A mouse sepsis model was established through caecum ligation and puncture (CLP). Animals were divided into four groups: control, sham, CLP and CLP+splenectomy (CLPS). Plasma concentrations of IL-6, IL-1β, TnI and NT-proBNP were measured. CD11b+Gr-1+ cells were detected by immunofluorescence staining and RT-PCR. Myocardial injury was detected by HE, Masson and TUNEL staining. The expression of mTOR, P53 and caspase-3 was measured by Western blot.

Results

In sepsis patients, circulating MDSCs were increased, and the plasma concentrations of IL-6 and IL-1β were elevated. The plasma concentrations of IL-6 and IL-1β were correlated with the ratio of circulating MDSCs. In the mouse sepsis model, the spleen was the major source of CD11b+Gr-1+ cells that migrated into circulation and the heart in sepsis. The serum concentrations of IL-6 and IL-1β were also elevated. Echocardiography and serum biomarkers showed that cardiomyocyte damage and cardiac hypofunction in sepsis induced myocardial imjury. The expression of CD11b, Gr-1 and pro-inflammatory cytokines in the heart was significantly higher in sepsis patients than that in controls. Pathological staining and TUNEL staining showed obvious myocardial damage and cell apoptosis. The Western blot analysis indicated that in the heart, the activation of mTOR was inhibited and that the expression of P53 and caspase-3 was elevated in sepsis-induced myocardial injury.

Conclusion

In sepsis-induced myocardial injury, splenic reservoir CD11b+Gr-1+ cells rapidly migrated into circulation and the heart, further impairing heart function via the high expression of P53 through the inhibition of mTOR.
Reasons of cancellation of elective surgical cases at the University Medical Center
Authors: Viderman Dmitriy , Zhumadilov Agzam , Umbetzhanov Yerlan , Ben-David Bruce 
Published: February 2019

Abstract
Background

Cancellation of scheduled cases on the day of surgery leads to waste of resources, financial burden, patient dissatisfaction, extended hospital stay, and unnecessary repetition of preoperative preparations. The purpose of this retrospective study was to analyze the causes of case cancellation in our institution so as to improve hospital quality control as well as perioperative risk management.

Methods

We conducted a retrospective analysis of all cancellations of scheduled elective surgical procedures. We analyzed all cases that were canceled after the patient had been delivered to the operating room (OR). The data about case cancellations was obtained from the Hospital Information System (HIS) of the National Research Oncology and Transplantation Center.

Results

The most common single reason for cancellation was preoperative hypertensive crisis (n=67; 80.7%), followed by heart rhythm disorders (n=6; 7.2%), incomplete preoperative patient evaluation (n=5; 6.1%), myocardial ischemia (n=4; 4.8%), and pneumonia (n=1; 1.2%). Most of the cancellations (76 out of 83; 92%) were considered to be potentially avoidable.

Conclusions

In conclusion, that the most common reasons for case cancellation were patient-related cardiovascular conditions (preoperative hypertensive crisis, dysrhythmia, myocardial ischemia). Improvement in preoperative assessment and management of the cardiovascular condition is needed to reduce scheduled case cancellation rate.
Changes in the Retinal Blood Flow after an Acute Intraocular Pressure Elevation Observed by Optical Coherence Tomography Angiography
Authors: Ma Ziwei , Qiu Wen-han , Yang Dan-ni Zhou Wei-hua , Pan Xue-feng , Chen Hong 
Published: February 2019

Abstract
Background:Although the pathogenesis of glaucoma is not fully understood ,an elevated intraocular pressure (IOP) is a major factor contributing to its development and progression. The aim of this study was to investigate the changes in the retinal blood flows of the macula and optic nerve head (ONH) after an acute elevation in the intraocular pressure (IOP) observed using optical coherence tomography angiography (OCTA).
Methods: This was a prospective comparative study of subjects with narrow anterior chamber angles who underwent laser peripheral iridotomies (LPIs). The IOP was measured before and one hour after the LPI. The retinal blood flows of the macula and ONH were measured using OCTA at the baseline and one hour after the LPI.
Results: A total of 64 eyes of 51 individuals were enrolled in this study, and 58 eyes of 43 individuals finally completed the study with a mean IOP rise of 10.5 ± 7.6 mmHg after the LPI. Based on the magnitude of the rise in the IOP, we divided the subjects into three groups: group A = IOP rise ≤ 10 mmHg, group B = 10 mmHg < IOP rise ≤ 20 mmHg, and group C = IOP rise > 20 mmHg. The vessel density did not differ after the acute IOP elevation in either the macular region or papillary region in group A or group B (p > 0.05), but there was a significant difference in group C (p < 0.05). However, when the subjects were not separated into groups, the vessel densities of the ONH and macular region did not differ between the measurements obtained at the baseline and one hour after the LPI (p>0.05).
Conclusion: In these normal subjects, an acute mild or moderate IOP elevation for one hour after the LPI did not affect the blood flow in the macula or ONH, as examined using OCTA. However, when the IOP rise was greater than 20 mmHg, the macular and papillary blood flows decreased significantly.
In-situ drying of faecal sludge in breathable membrane-lined collection containers
Authors: Saxena Shray , Ebrazibakhshayesh Babak , Dentel Steven K. , Imhoff Paul T. , Cha Daniel K. 
Published: February 2019

Abstract
Drying of faecal sludge enclosed in a breathable, hydrophobic membrane laminate was investigated for the potential application of breathable membranes in decentralized container-based sanitation systems for developing nations. Moisture loss from the membrane-enclosed faecal sludge was studied using membrane ‘envelopes’ filled with faecal sludge collected from random volunteers. A drying test with a new membrane envelope resulted in 71.2% mass reduction over a period of 7 days with an average moisture flux of 0.73 g/day-cm2. Slight decrease in the sludge drying rates was observed over five reuses of the same membrane envelope. A stagnant film model was used to predict drying rates of membrane-enclosed faecal sludge in ten developing countries with high urban populations. Based on a loading rate of 15 L/day into a 200-L (55-gallon) collection container, the predicted drying rates range from 7.1 to 12.4 L/day. The filling time of the membrane-lined container decreased due to in-situ drying, resulting in longer operation time and less frequent emptying of the container.
Synthesis and characterization of clinoptilolite-alginate beads for dye removal from water
Authors: Nigiz F. U. 
Published: February 2019

Abstract
The aim of this study is to synthesize a superior adsorbent by combining positive properties of alginate and natural zeolite (clinoptilolite). Electrostatic interactions between the negatively charged carboxyl groups in alginate, porous sites in clinoptilolite and positively charged cationic dye in wastewater make alginate and clinoptilolite superior for dye removal. A model wastewater was prepared with varying concentrations of methylene blue (MB). Effects of MB concentration, adsorption time, pH, and adsorbent concentration on adsorption performance were evaluated. Composite adsorbents were also characterized using Fourier transform infrared spectroscopy. While 97.0% of removal was achieved using 5 g/L adsorbent, 98.8% of removal was obtained using 15 g/L adsorbent dosage. When the dye concentrations were gradually decreased from 5 mg/L to 2 mg/L, dye removal of 96.9%, 97.7%, 97.9% and 98.4% were observed at the end of 180 minutes.
The Prevalence of Specific Phobia by Age in an Italian Nationwide Survey: How Much Does it Affect the Quality of Life?
Authors: Sancassiani Federica , Romano Ferdinando , Balestrieri Matteo , Caraci Filippo , Di Sciascio Guido , Drago Filippo , Hardoy Maria Carolina , Moro Maria Francesca , Roncone Rita , Piras Martina , Preti Antonio , Dell’Osso Liliana , Faravelli Carlo , Carta Mauro Giovanni 
Published: February 2019

Introduction:
The study aimed to see if a community survey conducted by clinical interviewers with semi-structured psychiatric interviews shows lifetime prevalence rates of Specific Phobia (SP) similar to those found by surveys carried out by lay interviewers and if the high level of impairment found in SP may be confirmed.

Methods:
This is a community survey on an Italian nationwide sample randomly selected from registers of municipalities. Tools: semi-structured ANTAS psychiatric interview derived from the SCID-DSM-IV, carried out by clinicians (psychologists or physicians); Short Form Health Survey (SF-12) as a measure of Quality of Life (QoL). Analyses: means of the χ2 test odds ratios were adopted to test several associations regarding SP prevalence. One-way ANOVA was used to compare different groups on attributable burden due to SP and/or other disorders in worsening QoL.

Results:
The lifetime prevalence of SP was 2.3%. No difference was found by age class. Females showed more than twice the frequency of males (p<0.0001). The disorders showing the closest association with SP were: social phobia (OR=17.53); general anxiety disorder (OR=11.57); anorexia (OR=11.13) and agoraphobia (OR=10.03), but also obsessive compulsive disorders (OR=8.8), eating disorders (OR=7.2), panic disorder (OR=5.9), post-traumatic stress disorder (OR=5.8), and major depressive disorder (OR=4.8) presented an association that achieved statistical significance. The QoL of people with SP and at least one disorder of anxiety, mood or eating in comorbidity, measured as a score at SF12, was worse than controls without SP (p <0.001) but that of people with SP without co-morbidity was not (p = 0.809).

Conclusion:
An epidemiological study conducted by clinical interviewers through semi-structured interviews appears to re-dimension the impact of SP, at least from the public health perspective. Future prospective studies will better clarify the role of SP in the context of anxiety disorders.