bluuebunny/crossref_metadata_2025_split huggingface dataset:
miR‐483‐3p suppresses the proliferation and progression of human triple negative breast cancer cells by targeting the HDAC8>oncogene
Authors: Menbari Mohammad‐Nazir , Rahimi Karim , Ahmadi Abbas , Mohammadi‐Yeganeh Samira , Elyasi Anvar , Darvishi Nikoo , Hosseini Vahedeh , Abdi Mohammad 
Published: September 2019

AbstractTriple negative breast cancer (TNBC) is a heterogeneous subclass of breast cancer (BC) distinguished by lack of hormone receptor expression. It is highly aggressive and difficult to treat with traditional chemotherapeutic regimens. Targeted‐therapy using microRNAs (miR) has recently been proposed to improve the treatment of TNBC in the early stages. Here, we explore the roles of miR‐483‐3p/HDAC8 HDAC8 premiR‐vector on tumorigenicity in TNBC patients. Clinical TNBC specimens and three BC cell lines were prepared. miR‐483‐3p and expression levels were measured using quantitative real‐time polymerase chain reaction. Cell cycle progression was assessed by a flow‐cytometry method. We also investigated cell proliferation by 3‐2, 5‐diphenyl tetrazolium bromide assay and colony formation assay. We used a to overexpress miR‐483‐3p, and a HDAC8‐KO‐vector for knocking out the endogenous production of HDAC8. Our data showed significant downregulation of miR‐483‐3p expression in TNBC clinical and cell line samples. The HDAC8 was also upregulated in both tissue specimens and BC cell lines. We found that increased levels of endogenous miR‐483‐3p affects tumorigenecity of MDA‐MB‐231. Downregulation of HDAC8 using the KO‐vector showed the same pattern. Our results revealed that the miR‐483‐3p suppresses cellular proliferation and progression in TNBC cell lines via targeting HDAC8. Overall, our outcomes demonstrated the role of miR‐483‐3p as a tumor suppressor in TNBC and showed the possible mechanism via HDAC8. In addition, targeted treatment of TNBC with miR‐483‐3p might be considered in the future.
Chitosan hydrochloride mediated efficient, green catalysis for the synthesis of perimidine derivatives
Authors: Shelke Premchand B. , Mali Suraj N. , Chaudhari Hemchandra K. , Pratap Amit P. 
Published: September 2019

AbstractChitosan hydrochloride as biopolymer‐based, renewable, and recyclable heterogeneous catalyst was used for efficient one‐pot synthesis of perimidine derivatives. This newly developed greener methodology provides a very simple and greener route for the synthesis of perimidines in short time with excellent yield.
Synthesis and characterization of some novel bis‐thiazoles
Authors: Mahmoud Huda K. , Kassab Refaie M. , Gomha Sobhi M. 
Published: September 2019

AbstractThe bis‐thiosemicarbazone derivative 3 was prepared and reacted with N‐aryl‐2‐oxopropane hydrazonoyl chloride 4a‐g and ethyl (N‐arylhydrazono)chloroacetate 7a‐e in absolute ethanol in the presence of triethylamine at reflux afforded a new series of thiazoles 6a‐g and 9a‐e, respectively. Also, thiosemicarbazone derivative 3 was reacted with N′‐phenylbenzohydrazonoyl chloride 10 to give the respective bis‐thiadiazole derivative 12. Moreover, the reaction of 3 with a number of haloketones and haloesters furnished the respective bis‐thiazole derivatives 14, 16, 18, and 20. The mechanisms that account for formation of products 6, 9, and 12 were discussed. Also, the molecular structure of the synthesized compounds was illustrated by spectroscopic and elemental analysis.
Diagnosis and clinical outcomes of extrapulmonary tuberculosis in antiretroviral therapy programmes in low‐ and middle‐income countries: a multicohort study
Authors: Zürcher Kathrin , Ballif Marie , Kiertiburanakul Sasisopin , Chenal Henri , Yotebieng Marcel , Grinsztejn Beatriz , Michael Denna , Sterling Timothy R , Ngonyani Kapella M , Mandalakas Anna M , Egger Matthias , Pettit April C , Fenner Lukas ,   the International Epidemiology Databases to Evaluate AIDS (IeDEA) consortium
Published: September 2019

AbstractIntroductionExtrapulmonary tuberculosis (EPTB) is difficult to confirm bacteriologically and requires specific diagnostic capacities. Diagnosis can be especially challenging in under‐resourced settings. We studied diagnostic modalities and clinical outcomes of EPTB compared to pulmonary tuberculosis (PTB) among HIV‐positive adults in antiretroviral therapy (ART) programmes in low‐ and middle‐income countries (LMIC).MethodsWe collected data from HIV‐positive TB patients (≥16 years) in 22 ART programmes participating in the International Epidemiology Databases to Evaluate AIDS (IeDEA) consortium in sub‐Saharan Africa, Asia‐Pacific, and Caribbean, Central and South America regions between 2012 and 2014. We categorized TB as PTB or EPTB (EPTB included mixed PTB/EPTB). We used multivariable logistic regression to assess associations with clinical outcomes.Results and DiscussionWe analysed 2695 HIV‐positive TB patients. Median age was 36 years (interquartile range (IQR) 30 to 43), 1102 were female (41%), and the median CD4 count at TB treatment start was 114 cells/μL (IQR 40 to 248). Overall, 1930 had PTB (72%), and 765 EPTB (28%). Among EPTB patients, the most frequently involved sites were the lymph nodes (24%), pleura (15%), abdomen (11%) and meninges (6%). The majority of PTB (1123 of 1930, 58%) and EPTB (582 of 765, 76%) patients were diagnosed based on clinical criteria. Bacteriological confirmation (using positive smear microscopy, culture, Xpert MTB/RIF, or other nucleic acid amplification tests result) was obtained in 897 of 1557 PTB (52%) and 183 of 438 EPTB (42%) patients. EPTB was not associated with higher mortality compared to PTB (adjusted odd ratio (aOR) 1.0, 95% CI 0.8 to 1.3), but TB meningitis was (aOR 1.9, 95% CI 1.0 to 3.1). Bacteriological confirmation was associated with reduced mortality among PTB patients (aOR 0.7, 95% CI 0.6 to 0.8) and EPTB patients (aOR 0.3 95% CI 0.1 to 0.8) compared to TB patients with a negative test result.ConclusionsDiagnosis of EPTB and PTB at ART programmes in LMIC was mainly based on clinical criteria. Greater availability and usage of TB diagnostic tests would improve the diagnosis and clinical outcomes of both EPTB and PTB.
Syk-dependent glycolytic reprogramming in dendritic cells regulates IL-1β production to β-glucan ligands in a TLR-independent manner
Authors: Thwe Phyu M , Fritz Daniel I , Snyder Julia P , Smith Portia R , Curtis Kylie D , O'Donnell Alexandra , Galasso Nicholas A , Sepaniac Leslie A , Adamik Benjamin J , Hoyt Laura R , Rodriguez Princess D , Hogan Tyler C , Schmidt Andrea F , Poynter Matthew E , Amiel Eyal 
Published: September 2019

Abstract
Dendritic cells (DCs) activated via TLR ligation experience metabolic reprogramming, in which the cells are heavily dependent on glucose and glycolysis for the synthesis of molecular building blocks essential for maturation, cytokine production, and the ability to stimulate T cells. Although the TLR-driven metabolic reprogramming events are well documented, fungal-mediated metabolic regulation via C-type lectin receptors such as Dectin-1 and Dectin-2 is not clearly understood. Here, we show that activation of DCs with fungal-associated β-glucan ligands induces acute glycolytic reprogramming that supports the production of IL-1β and its secretion subsequent to NOD-, LRR- and pyrin domain-containing protein 3 (NLRP3) inflammasome activation. This acute glycolytic induction in response to β-glucan ligands requires spleen tyrosine kinase signaling in a TLR-independent manner, suggesting now that different classes of innate immune receptors functionally induce conserved metabolic responses to support immune cell activation. These studies provide new insight into the complexities of metabolic regulation of DCs immune effector function regarding cellular activation associated with protection against fungal microbes.
Efficient large‐scale scattering analysis of objects in a stratified medium
Authors: Zhang Kedi , Goddard Lynford L. , Jin Jian‐Ming 
Published: September 2019

AbstractAn efficient method is presented to analyze electromagnetic scattering of large‐scale objects in a stratified medium. The method introduces an inhomogeneous absorbing boundary condition (ABC) to truncate an infinite stratified medium for the finite‐element analysis. It then adopts the dual‐primal finite‐element tearing and interconnecting (FETI‐DP) algorithm with distributed computing to enable and speed up large‐scale simulations on a computer cluster. Finally, the method utilizes the reciprocity theorem to simplify scattered field calculation and employs the multilevel fast multipole algorithm (MLFMA) to improve the computational efficiency. Three verification examples are presented to demonstrate the solution accuracy of the proposed method, followed by an electrically large example to demonstrate the capability of the method for large‐scale electromagnetic modeling of objects in a stratified medium.
Impact of human disturbance on the biogeochemical silicon cycle in a coastal sea revealed by silicon isotopes
Authors: Zhang Zhouling , Sun Xiaole , Dai Minhan , Cao Zhimian , Fontorbe Guillaume , Conley Daniel J. 
Published: September 2019

AbstractBiogeochemical silicon (Si) cycling in coastal systems is highly influenced by anthropogenic perturbations in recent decades. Here, we present a systematic study on the distribution of stable Si isotopes of dissolved silicate (δ30SiDSi) in a highly eutrophic coastal system, the Baltic Sea. Besides the well‐known processes, diatom production and dissolution regulating δ30SiDSi values in the water column, we combined field data with a box model to examine the role of human disturbances on Si cycling in the Baltic Sea. Results reveal that (1) damming led to increased δ30SiDSi values in water but had little impacts on their vertical distribution; (2) decrease in saltwater inflow due to enhanced thermal stratification had negligible impacts on the δ30SiDSi distribution. An atypical vertical distribution of δ30SiDSi with higher values in deep water (1.57–1.95‰) relative to those in surface water (1.24–1.68‰) was observed in the central basin. Model results suggest the role of enhanced biogenic silica (BSi) deposition and subsequently regenerated dissolved silicate (DSi) flux from sediments. Specifically, eutrophication enhances diatom production, resulting in elevated exports of highly fractionated BSi to deep water and sediments. In situ sedimentary geochemical processes, such as authigenic clay formation, further fractionate Si isotopes and increase pore‐water δ30SiDSi values, which then leads to pore‐water DSi flux carrying higher δ30SiDSi compositions into deep water. Our findings provide new quantitative information on how the isotope‐based Si cycle responds to human perturbations in coastal seas and shed lights on shifts of Si export to open ocean.
Perspectives for Applications of Quantum Imaging
Authors: Gilaberte Basset Marta , Setzpfandt Frank , Steinlechner Fabian , Beckert Erik , Pertsch Thomas , Gräfe Markus 
Published: September 2019

AbstractQuantum imaging is a multifaceted field of research that promises highly efficient imaging in extreme spectral ranges as well as ultralow‐light microscopy. Since the first proof‐of‐concept experiments over 30 years ago, the field has evolved from highly fascinating academic research to the verge of demonstrating practical technological enhancements in imaging and microscopy. Here, the aim is to give researchers from outside the quantum optical community, in particular those applying imaging technology, an overview of several promising quantum imaging approaches and evaluate both the quantum benefit and the prospects for practical usage in the near future. Several use case scenarios are discussed and a careful analysis of related technology requirements and necessary developments toward practical and commercial application is provided.
Unique Design Strategy for Laser‐Driven Color Converters Enabling Superhigh‐Luminance and High‐Directionality White Light
Authors: Zheng Peng , Li Shuxing , Wei Ran , Wang Le , Zhou Tian‐Liang , Xu Yi‐Rong , Takeda Takashi , Hirosaki Naoto , Xie Rong‐Jun 
Published: September 2019

AbstractRobust ceramic color converters withstanding strong laser irradiations have recently drawn great attention for laser‐driven white lighting. However, the local emission within the incident laser spot usually expands to the whole surface area of the ceramics, which definitely makes it hard to achieve white light with high luminance and high directionality. Herein, a new strategy is proposed to solve the problem by elaborately introducing uniform spherical pores (diameter of ≈2 µm) into the phosphor ceramics with controlled contents from 8 to 24.6 vol%. The well‐distributed pores, acting as light scattering centers, enable reduction of the luminescent spot size greatly but without any losses in conversion efficiency. By using the high‐scattering ceramic color converters with 15% porosity, the light spot diameter is decreased by 46% and the central illuminance is increased by 156%. Moreover, laser‐driven white light with an enhanced beam directionality and uniformity is also achieved. A superhigh luminous flux of 7199 lm is realized by using this promising color converter in a rotary mode. The designed high‐scattering ceramics with controllable microstructures show great potential for use in extra‐high luminance laser‐driven lighting and projection.
When social intrusiveness depletes customer value: A balanced perspective on the agency of simultaneous sharers in a commercial sharing experience
Authors: Simon Françoise , Roederer Claire 
Published: September 2019

AbstractA major pattern of non‐ownership consumption is “simultaneous sharing,” whereby customers simultaneously share the same resource in either a virtual or physical setting. However, little research examines the actual value that consumers derive from such a group‐based commercial experience. By integrating the literature on customer value and the psychology of autonomy, this study proposes a theoretical model of the simultaneous sharing experience that balances the benefits and social intrusiveness of sharer agency. Based on data that were collected from members of a collaborative platform dedicated to flat sharing and analyzed through structural equation modeling, social intrusiveness is found to be a pervasive phenomenon that strongly impairs customer satisfaction, whereas communal benefits, as reflected by enjoyment, companionship, informational guidance, and emotional support, enhance it. As a major antecedent of both communal benefits and intrusiveness, perceived homophily nourishes satisfaction, however, customer age may reduce the buffering influence of perceived homophily on intrusiveness, whereas an additional positive effect on communal benefits is associated with the sharer social integrative motive. We discuss the implications of this study for customer experience and commercial sharing consumption research.
The Relationship between Specific Structure and Gas Permeability of Bromobutyl Rubber: A Combination of Experiments and Molecular Simulations
Authors: Cai Fei , You Guohua , Zhao Xiuying , Hu Haihua , Wu Sizhu 
Published: September 2019

AbstractThe relationship between the specific structure and gas permeability of brominated poly(isobutylene‐co‐isoprene) rubber (BIIR) is investigated by a combination method of both experiments and molecular simulation. It is found that the various content of secondary allyl bromide isoprene (SABI) units exert an effect on transport behavior, including both diffusion and solution behavior of small molecule in BIIR, glass transition temperature, and vulcanization characteristics. The results show that a minimum value of permeability coefficient exists with the increase of SABI content. Moreover, more SABI in BIIR will lead to a rise in glass transition temperature and curing rate. It means that the gas permeability of BIIR can be further improved by adjusting composition of the copolymer BIIR. Meanwhile, this research may also provide useful information for understanding the penetration mechanism of oxygen in the BIIR matrix and supply a theoretical tool for designing high air tightness rubber materials.
The Relevance of Multi‐Injection and Temperature Profiles to Design Multi‐Phase Reactive Processing of Polyolefins
Authors: Hernández‐Ortiz Julio C. , Van Steenberge Paul H. M. , Duchateau Jan N. E. , Toloza Carolina , Schreurs Fons , Reyniers Marie‐Françoise , Marin Guy B. , D'hooge Dagmar R. 
Published: September 2019

AbstractFor industrial‐scale continuous free radical induced grafting of polyethylene, which involves the contact of a monomer‐ and polymer‐rich phase, it is demonstrated that the functionalization selectivity and grafting density can be significantly improved (e.g., 100%) by considering multiple injection of monomer and/or a temperature profile. With parameters taken from literature, it is highlighted through simulations that step‐wise addition of monomer allows to reduce the homopolymerization rate, and an increased temperature at the start of the reactive processing allows to increase the hydrogen abstraction rate, so that more potential grafting points can be generated. As this increased grafting density goes along with a lower reaction extent, a better process efficiency is obtained albeit at a lowering of the average chain length of the grafts and an increase of the crosslinking density. In any case, a broader span of polymer characteristics (e.g., ranges of grafting/crosslinking densities and functionalization yields) can be achieved by including variations in reactant addition and temperature profiles.
Clinical and neurophysiological variability in Andersen‐Tawil syndrome
Authors: Kokubun Norito , Aoki Reika , Nagashima Takahide , Komagamine Tomoko , Kuroda Yusuke , Horie Minoru , Hirata Koichi 
Published: September 2019

AbstractIntroductionAndersen‐Tawil syndrome (ATS) is characterized by a triad of periodic paralysis, ventricular arrhythmias, and dysmorphism. However, patients often lack one or more of these features.MethodsClinical and neurophysiological features were reviewed of five members in two families with heterozygous mutations in KCNJ2 (R218Q and R67W).ResultsOnly one patient had all features of the triad of ATS. One patient had low‐set ears, and the others had minor anomalies. Bidirectional ventricular tachycardias were seen in two patients. Two patients (R67W) never had episodes of paralysis. The long exercise test was abnormal in three patients with episodes of paralysis, but normal in two without paralytic episodes.DiscussionATS patients without skeletal muscle symptoms can have normal neurophysiological examinations. They can show variability in phenotype or the severity of arrhythmias. Such variability among patients who share the same gene mutations may result in underdiagnosis of ATS.
Synthesis and Magnetic Properties of a Copper Cube: [Cu4(OH)4(C16H18N2)4]4+ (ClO4)4 C3H6O [C16H18N2=(E)‐1,6‐[Di(pyridin‐4‐yl)hex‐3‐ene]
Authors: Plater M. John , Darr Amara , Crawford Catriona , Murray Craig , Simpson Struan , Harrison William T. A. , Clemente‐Juan Juan M. 
Published: September 2019

AbstractThe synthesis of a Cu4(OH)4 cube which is coordinated by four molecules of the dipyridyl ligand 1,6‐[di(pyridin‐4‐yl)hex‐3‐ene] is reported. This compound has a trans double bond which restricts the conformational freedom of the ligand and favours coordination within a unique copper cube. The structure was solved by an X‐Ray single crystal structure determination and low temperature magnetic susceptibility measurements examined its magnetic properties. The cube classification corresponds to the type I classification of Mergehenn and Haase and the short/long distribution of Cu ⋅⋅⋅ Cu separations in the cube as defined by Ruiz. The magnetic susceptibility measurements show paramagnetic behaviour down to 50 K but below this the copper cube shows weak ferromagnetic exchange interactions. The low temperature magnetic susceptibility characteristics are examined in detail then modelled and compared to other similar Cu4O4 copper cubes.
Physico‐mechanical properties of tamarind pod shell‐based composite
Authors: Goudar Santosha , Jain Ravi Kant , Das Debashis 
Published: September 2019

AbstractThe main objective and novelty of this study is to investigate the effect of particle size and alkali treatment on physical, mechanical properties of tamarind pod shell (TPS)‐reinforced epoxy composites. The treated and untreated composites were fabricated with different particle sizes with TPS content of 10 wt%. The mechanical, physical, and morphological properties of specimens were investigated. It was revealed that the density and mechanical properties of the treated and untreated composites increased with the decrease in the particle size; whereas, the water absorption percentage and void content decreased for the same. The treated composite with the particle size of 75 μm exhibited the maximum tensile, flexural, and compressive strength. Further, the multiscale finite element (FE) model was developed using the Digimat‐FE software to simulate the tensile behavior of composites with different particle size. The simulation results revealed that the stress concentration level was more in the vicinity of the voids, and the higher stress concentration was observed in the matrix phase with the increase in particle size. Also, it was found that the predicted results from the multiscale FE model showed a good agreement with the experimental results. The results suggested that the TPS filled epoxy composites have potential utility in the fields of automotive interior panels, particulate board panels, household goods, packaging materials, building partitions, and many other applications.
Initiation of generic imatinib may improve medication adherence for patients with chronic myeloid leukemia
Authors: Cole Ashley L. , Jazowski Shelley A. , Dusetzina Stacie B. 
Published: September 2019

AbstractPurposeTo compare adherence to tyrosine kinase inhibitors (TKIs) between patients with chronic myeloid leukemia (CML) who initiated branded or generic imatinib.MethodsWe used MarketScan commercial claims data (January 2011‐June 2018) to identify patients with CML who newly initiated branded imatinib before 1 August 2015 or generic imatinib on or after 2 February 2016, and were continuously enrolled in health plans for 6 months before through 6 months following their initial fill. After inverse probability of treatment weighting, we compared adherence (proportion of days covered [PDC]) and persistence (no gaps ≥30 and ≥60 consecutive days in therapy) to TKI therapy.ResultsPatients initiating generic imatinib consistently had higher average PDC per month and over the 6‐month follow‐up period than initiators of branded imatinib. Average 6‐month PDC was 92% (95%CI:89%‐94%) for generic initiators and 85% (95%CI:83%‐86%) for brand initiators. Compared with branded imatinib initiators, a larger proportion of generic imatinib initiators were adherent and persistent to TKI therapy (PDC ≥ 90%:78% versus 64%; no≥60‐day gap:94% versus 86%).ConclusionsPatients initiating generic imatinib achieved clinically significant improvements in adherence to TKI therapy relative to branded drug users, presumably due to lower out‐of‐pocket costs. Given the importance of optimal adherence in CML, considering barriers to adherence (eg, patient‐cost sharing and health benefit design) when selecting initial treatment may improve long‐term medication adherence. Pharmacoepidemiologic studies should consider how best to account for expected cost‐sharing and its impact on adherence and subsequent clinical outcomes.