bluuebunny/crossref_metadata_2025_split huggingface dataset:
DNA Methylation Biomarkers Of Myocardial Infarction And Cardiovascular Disease
Authors: Fernández-Sanlés Alba , Sayols-Baixeras Sergi , Subirana Isaac , Sentí Mariano , Pérez-Fernández S , de Moura Manuel Castro , Esteller Manel , Marrugat Jaume , Elosua Roberto 
Published: July 2019

ABSTRACTObjectiveTo assess the association between DNA methylation and acute myocardial infarction, the predictive added value of the identified methylation marks, and the causality of those associations.Approach and ResultsWe conducted a case-control, two-stage, epigenome-wide association study on acute myocardial infarction (ndiscovery=391, nvalidation=204). DNA methylation was assessed using the Infinium MethylationEPIC BeadChip (over 850,000 CpGs). DNA methylation was the exposure variable and myocardial infarction the outcome of interest. After a fixed-effects meta-analysis, 34 CpGs fulfilled Bonferroni significance. These findings were also analysed in two independent cohort studies (n∼1,800 and n∼2,500) with incident coronary (CHD) and cardiovascular disease (CVD). The Infinium HumanMethylation450 BeadChip was used in these two studies (over 480,000 CpGs) and only 12 of the 34 CpGs were available in those samples. Finally, we validated four of them in association with incident CHD:AHRR-mapping cg05575921,PTCD2-mapping cg25769469, intergenic cg21566642 andMPO-mapping cg04988978. The four CpGs were also associated with classical cardiovascular risk factors. A methylation risk score based on those CpGs did not improve the predictive capacity of the Framingham risk function. To assess the causal effects of those CpGs we performed Mendelian randomization analysis but only one metQTL could be identified and the results were not conclusive.ConclusionsWe have identified 34 CpGs related to acute myocardial infarction. These loci highlight the relevance of smoking, lipid metabolism, and inflammation in the biological mechanisms related to myocardial infarction. Four were additionally associated with incident CHD and CVD but did not provide additional predictive information.
Respiration competes with theta for modulating parietal cortex neurons
Authors: Jung Felix , Yanovsky Yevgenij , Brankačk Jurij , Tort Adriano BL , Draguhn Andreas 
Published: July 2019

AbstractRecent work has shown that nasal respiration entrains local field potential (LFP) and neuronal activity in widespread regions of the brain. This includes non-olfactory regions where respiration-coupled oscillations have been described in different mammals, such as rodents, cats and humans. They may, thus, constitute a global signal aiding interregional communication. Nevertheless, the brain produces other widespread slow rhythms, such as theta oscillations, which also mediate long-range synchronization of neuronal activity. It is completely unknown how these different signals interact to control neuronal network activity. In this work, we characterized respiration- and theta-coupled activity in the posterior parietal cortex of mice. Our results show that respiration-coupled and theta oscillations have different laminar profiles, in which respiration preferentially entrains LFPs and units in more superficial layers, whereas theta modulation does not differ across the parietal cortex. Interestingly, we find that the percentage of theta-modulated units increases in the absence of respiration-coupled oscillations, suggesting that both rhythms compete for modulating parietal cortex neurons. We further show through intracellular recordings that synaptic inhibition is likely to play a role in generating respiration-coupled oscillations at the membrane potential level. Finally, we provide anatomical and electrophysiological evidence of reciprocal monosynaptic connections between the anterior cingulate and posterior parietal cortices, suggesting a possible source of respiration-coupled activity in the parietal cortex.
Feeding intensity and molecular prey identification of the common long-armed octopus, Octopus minor (Mollusca: Octopodidae) in the wild
Authors: Bo Qi-Kang , Zheng Xiao-Dong , Chen Zhi-Wei 
Published: July 2019

AbstractThe common long-armed octopus, Octopus minor, is an important component of systems and supports the local fisheries in the coastal areas of northern China. And because of the overfishing, the national germplasm reserve was established as conservation area at the Moon Lake for the genetic resource of O.minor in 2012. For the fishery management and artificial breeding, especially for the management of exclusive conservation reserves, its role in the ecosystem requires assessment. Therefore, the feeding intensity of O. minor was studied from April to July 2014 when females reaching maturation, and prey composition was identified from stomach contents using a DNA barcoding method. Of the 172 sampled octopuses, 66 had stomach contents that were nearly digested into pulp. Maximum feeding intensity occurred during the month of April and the feeding intensity of the females was greater than that of the males in April and May. A considerable overall reduction of feeding intensity in both sexes occurred from April to July. A total of 8 species were identified as the prey of O. minor. Based on homology searches and phylogenetic analysis, of 60 sequences, 30 matched with fish (50.00%, by number), 13 with crustaceans (21.66%), one with annelid (1.66%), one with nematode (1.66%) and 15 with itself (25.00%). These results confirm that O. minor has habitual nature of strong dietary preference, with Gobiidae families (62.79%, by number) being an important prey during the time when females reach sexual maturation. From April to July, the observed cannibalism showed an increasing trend.
Uncoupling the roles of firing rates and spike bursts in shaping the STN-GPe beta band oscillations
Authors: Bahuguna Jyotika , Sahasranamam Ajith , Kumar Arvind 
Published: July 2019

AbstractThe excess of 15-30 Hz (β-band) oscillations in the basal ganglia is one of the key signatures of Parkinson’s disease (PD). The STN-GPe network is integral to generation and modulation of β band oscillations in basal ganglia. However, the role of changes in the firing rates and spike bursting of STN and GPe neurons in shaping these oscillations has remained unclear. In order to uncouple their effects, we studied the dynamics of STN-GPe network using numerical simulations. In particular, we used a neuron model, in which firing rates and spike bursting can be independently controlled. Using this model, we found that while STN firing rate is predictive of oscillations but GPe firing rate is not. The effect of spike bursting in STN and GPe neurons was state-dependent. That is, only when the network was operating in a state close to the border of oscillatory and non-oscillatory regimes, spike bursting had a qualitative effect on the β band oscillations. In these network states, an increase in GPe bursting enhanced the oscillations whereas an equivalent proportion of spike bursting in STN suppressed the oscillations. These results provide new insights into the mechanisms underlying the transient β bursts and how duration and power of β band oscillations may be controlled by an interplay of GPe and STN firing rates and spike bursts.Author summaryThe STN-GPe network undergoes a change in firing rates as well as increased bursting during excessive β band oscillations during Parkinson’s disease. In this work we uncouple their effects by using a novel neuron model and show that presence of oscillations is contingent on the increase in STN firing rates, however the effect of spike bursting on oscillations depends on the network state. In a network state on the border of oscillatory and non-oscillatory regime, GPe spike bursting strengthens oscillations. The effect of spike bursting in the STN depends on the proportion of GPe neurons bursting. These results suggest a mechanism underlying a transient β band oscillation bursts often seen in experimental data.
Matching whole genomes to rare genetic disorders: Identification of potential causative variants using phenotype-weighted knowledge in the CAGI SickKids5 clinical genomes challenge
Authors: Pal Lipika R. , Kundu Kunal , Yin Yizhou , Moult John 
Published: July 2019

ABSTRACTPrecise identification of causative variants from whole-genome sequencing data, including both coding and non-coding variants, is challenging. The CAGI5 SickKids clinical genome challenge provided an opportunity to assess our ability to extract such information. Participants in the challenge were required to match each of 24 whole-genome sequences to the correct phenotypic profile and to identify the disease class of each genome. These are all rare disease cases that have resisted genetic diagnosis in a state-of-the-art pipeline. The patients have a range of eye, neurological, and connective-tissue disorders. We used a gene-centric approach to address this problem, assigning each gene a multi-phenotype-matching score. Mutations in the top scoring genes for each phenotype profile were ranked on a six-point scale of pathogenicity probability, resulting in an approximately equal number of top ranked coding and non-coding candidate variants overall. We were able to assign the correct disease class for 12 cases and the correct genome to a clinical profile for five cases. The challenge assessor found genes in three of these five cases as likely appropriate. In the post-submission phase, after careful screening of the genes in the correct genome we identified additional potential diagnostic variants, a high proportion of which are non-coding.
Quality analysis using three-dimensional modelling and image processing techniques
Authors: Marzouk Mohamed , Hassouna Mahmoud 
Published: July 2019

Purpose
This paper aims to propose a system for defect detection in constructed elements that is able to indicate deformity positions. It also evaluates the defects in finishing materials of constructed building elements to support the subjective visual quality investigation of the aesthetics of an architectural work.

Design/methodology/approach
This strategy depends on defect features analysis that evaluates the defect value in digital images using digital image processing methods. The research uses the three-dimensional (3D) modeling techniques and image processing algorithms to generate a system that is able to perform some of the monitoring activities by computers. Based on the collected site scans, a 3D model is created for the building. Then, several images can be exported from the 3D model to investigate a specific element. Different image denoizing techniques are compared such as mean filter, median filter, Wiener filter and Split–Bregman iterations. The most efficient technique is implemented in the system. Then, the following six different methods are used for image segmentation to separate the concerned object from the background; color segmentation, region growing segmentation, histogram segmentation, local standard deviation segmentation, adaptive threshold segmentation and mean-shift cluster segmentation.

Findings
The proposed system is able to detect the cracks and defected areas in finishing works and calculate the percentage of the defected area compared to the total captured area in the photo with high accuracy.

Originality/value
The proposed system increases the precision of decision-making by decreasing the contribution of human subjective judgment. Investigation of different finishing surfaces is applied to validate the proposed system.
Free convection in an inclined cavity filled with a nanofluid and with sinusoidal temperature on the walls
Authors: Cimpean Dalia Sabina , Pop Ioan 
Published: July 2019

Purpose
This paper aims to develop a numerical study of the steady natural convection in an inclined square porous cavity filled by a nanofluid with sinusoidal temperature distribution on the side walls and adiabatic conditions on the upper and lower walls.

Design/methodology/approach
Governing equations transformed in terms of the dimensionless variables using the Darcy–Boussinesq approximation have been solved numerically using a central finite-difference scheme. The Gaus-Siedel iteration technique was used for the system of discretized equations. The two-phase nanofluid model including the Brownian diffusion and thermophoresis effects has been considered for simulation of nanofluid transport inside the cavity.

Findings
The numerical results of streamlines, isotherms and isoconcentrations are investigated and the effect of different important parameters, such as inclination angle of the cavity, amplitude ratio of the sinusoidal temperature or phase deviation, is discussed. The results obtained for no inclination of the cavity are compared and successfully validated with previous reported results of the literature. The important findings of the study are focused on the changes made by the inclination angle and the periodic thermal boundary conditions, on the heat and fluid flow.

Originality/value
The originality of the present study is given by the mathematical model presented for an inclined cavity, the numerical solution with new results for inclined cavity and the applications for design of solar energy devices such as solar collectors in which the boundary conditions vary with time because of changes in weather conditions.
Numerical study of unsteady flow and heat transfer CNT-based MHD nanofluid with variable viscosity over a permeable shrinking surface
Authors: Ahmed Zahid , Nadeem Sohail , Saleem Salman , Ellahi Rahmat 
Published: July 2019

Purpose
The purpose of this paper is to present a novel model on the unsteady MHD flow of heat transfer in carbon nanotubes with variable viscosity over a shrinking surface.

Design/methodology/approach
The temperature-dependent viscosity makes the proposed model non-linear and coupled. Consequently, the resulting non-linear partial differential equations are first reformed into set of ordinary differential equations through appropriate transformations and boundary layer approximation and are then solved numerically by the Keller box method.

Findings
Graphical and numerical results are executed keeping temperature-dependent viscosity of nanofluid. It is noted that, for diverse critical points, it is found that at one side of these critical values, multiple solutions exist; on the other side, no solution exists. A comparison is also computed for the special case of existing study. The temperature and pressure profiles are also plotted for various effective parameters.

Originality/value
The work is original.
Talent management meta review: a validity network schema approach
Authors: Shulga Lenna V. , Busser James A. 
Published: July 2019

Purpose
The purpose of this paper is to critically assess the state of substantive, methodological and conceptual development of talent management (TM) within hospitality and business research and to identify gaps, examine debates and provide hospitality research direction.

Design/methodology/approach
After identifying 545 articles from 22 peer-reviewed journals from Google Scholar using “talent management,” only articles directly related to TM (n = 149) were analyzed using the validity network schema (VNS). The advantage of the VNS approach is in-depth analysis of the three research domains – substantive, methodological, and conceptual – and evaluation of the pathways between domains emerging in a unique hospitality TM perspective.

Findings
Substantive domain TM discourse analysis identified 12 general and 5 hospitality-related topics. The resulting research framework depicted how global trends, organizational, employee-specific factors and organizational-management tactics affect (1) organizational, (2) personal, (3) societal, and (4) customer outcomes. Methodological domain analysis revealed business TM research in the mature stage, while hospitality TM research is in the embryonic stage of development. TM researchers predominantly used observational, descriptive and industry-specific data, advancing the field with associated research frameworks. Conceptual domain analysis uncovered opportunities to advance theoretical foundations and test causal relationships.

Originality/value
VNS analysis identified the importance of conceptual, methodological and substantive domains of TM research. The comprehensive TM research framework was proposed with eight research pathways to guide future hospitality studies. This paper advances the unique hospitality industry-specific scholarship and practice, focused on employee well-being rather than solely organizational gain.
Macroeconomic conditions at workforce entry and job satisfaction
Authors: Çitçi Sadettin Haluk , Begen Nazire 
Published: July 2019

PurposeThe purpose of this paper is to examine whether individual experiences at workforce entry affect later job satisfaction.Design/methodology/approachThis study utilized the British Household Panel Survey for the years between 1991 and 2008. Ordered probit estimation is used for the analysis. Also fixed effect and pooled ordinary least squares methods are employed to make robustness check.FindingsThe results of the analyses show that people who enter the workforce when the unemployment rate is high have less job satisfaction even in later ages compared to the ones who enter the workforce when the unemployment rate is lower. Even controlling for important factors on job satisfaction, such as industry and occupation differences, age, gender and income, the effect of workforce entry conditions on job satisfaction continues to survive. The results indicate that high unemployment has larger and longer lasting negative welfare effects than commonly predicted.Social implicationsAn increment in workforce entry unemployment rate causes lower job satisfaction even years later of these early workforce experiences. The results indicate that high unemployment has larger and longer lasting negative welfare effects than commonly predicted.Originality/valueThe study is among the few that investigates macroeconomic experiences on job satisfaction and the first one providing evidence on the negative effect of entering the workforce in worse economic conditions on later job satisfaction.
The effect of immigration on natives’ task specialisation: the case of Germany
Authors: Sebastian Raquel , Ulceluse Magdalena 
Published: July 2019

Purpose
The purpose of this paper is to analyse the effect of an increase in the relative supply of immigrants on natives’ task reallocation, with a focus on Germany. Specifically, it investigates whether natives, as a response to increased immigration, re-specialise in communication-intensive occupations, where they arguably have a comparative advantage due to language proficiency.

Design/methodology/approach
The analysis uses regional data from the German Labour Force Survey between 2002 and 2014. To derive data on job tasks requirements, it employs the US Department of Labor’s O*NET database, the results of which are tested through a sensitivity analysis using the European Working Condition Survey and the Programme for the International Assessment of Adult Competencies data sets.

Findings
The paper finds that indeed German workers respond to increasing immigration by shifting their task supply and providing more communication relative to manual tasks. Importantly, the decrease in the supply of communication tasks is stronger and more robust than the increase in the supply of manual tasks, pointing to a potential displacement effect taking place between natives and immigrants, alongside task reallocation. This would suggest that countries with relatively more rigid labour markets are less responsive to immigration shocks. Moreover, it suggests that labour market rigidity can minimise the gains from immigration and exacerbate employment effects.

Originality/value
The paper not only investigates task reallocation as a result of immigration in a different institutional context and labour market functioning, but the results feed into broader policy and scholarly discussions on the effects of immigration, including questions about how the institutional context affects labour market adjustment to immigration, worker occupational mobility in a more rigid labour markets and the fine balance needed between flexibility and rigidity.
Sustainable service supply chain practices (SSSCPs): a framework development
Authors: Aliakbari Nouri Fahimeh , Shafiei Nikabadi Mohsen , Olfat Laya 
Published: July 2019

PurposeThe purpose of this paper is to develop a framework of sustainable service supply chain management (SCM) processes and practices in the multi-dimensional construct. It tries to provide a template for those sustainability general key practices that can be scheduled and budgeted in different service sectors.Design/methodology/approachTo provide an applicable framework, its adaptability to most service settings should be ensured. In this regard, at first, the related literature on service SCM processes and sustainability practices of SCM are reviewed. To modify and confirm the extracted list, it is distributed to experts. After summarizing experts’ opinions, an initial list of the sustainable service supply chain practices (SSSCPs) is provided. Finally, the Fuzzy Delphi Method is applied to construct the framework for hospital supply chain (SC).FindingsIt suggests that the SSSCPs can be constructed in terms of seven major processes: managing the sustainable supplier, sustainable employee, sustainable customer, sustainable service performance, sustainable service operations, sustainable external relations, and sustainable knowledge, information and technology.Practical implicationsThe framework can be employed as a template of sustainability practices for individual member firms of service SCs to identify and implement the key practices toward sustainability.Originality/valueReviewing the literature indicates that determining what is unique about the sustainable SCM in the service sector is immature. The paper is a preliminary effort to identify the general sustainability practices, in incorporating all sustainability dimensions in service SC processes.
Yoga wellness tourism: a study of marketing strategies in India
Authors: Telej Ewelina , Gamble Jordan Robert 
Published: July 2019

Purpose
The purpose of this paper is to examine marketing strategies that India is currently applying to promote itself as a competitive yoga destination.

Design/methodology/approach
The methodological approach consisted of a constructivist research paradigm, a qualitative methodology and an interview-based data collection method. Ten in-depth, semi-structured interviews were conducted with yoga practitioners from various backgrounds and yoga levels who have travelled to India for yoga tourism purposes.

Findings
The findings determined that interpretation of yoga tourism is crucial in the choice of marketing approach adopted by destinations offering yoga retreats because, as the study has shown, various perceptions of yoga constitute the basis for particular promotional strategies.

Research limitations/implications
Future research could expand on the sample size and demographics of the current study by investigating, possibly through comparative means, larger groups of more diversified yoga practitioners from different countries or backgrounds.

Practical implications
It was recommended that India’s tourism marketers re-design their approach concerning an ‘authentic’ yoga experience. Indian destination marketing organisations should target those searching for an authentic yoga experience and use imagery that is realistic.

Originality/value
The findings of this study have led to the re-positioning of yoga tourism in India, utilising a unique combinative approach in which a more inclusive concept of wellness is juxtaposed against a lack of any religious referencing. It was also revealed that the motivations of yoga tourists are only partially targeted through an undifferentiated strategic marketing approach.