bluuebunny/crossref_metadata_2025_split huggingface dataset:
Managing the demands of the preregistration mental health nursing programme: The views of students with mental health conditions
Authors: Ramluggun Pras , Lacy Mary , Cadle Martha , Anjoyeb Mahmood 
Published: May 2018

AbstractAn increasing number of students with a pre‐existing mental health condition are enrolling on preregistration mental health nursing programmes. The challenges faced by these students in managing the demands of the programme have not been fully explored. Mental health and well‐being is an integral part of providing a healthy university in which students can flourish. The purpose of the study was to explore how students with an underlying mental health issue manage the demands of the mental health nursing programme. The outcomes of the study are aimed at informing inclusive teaching and learning and current student support provision. Ethics approval was given. Students from two universities in South East England who met the criterion of having a pre‐existing mental health condition when enrolling on the mental health preregistration nursing programme were invited to take part. Nine students took part in the study. Using an interpretative descriptive design, 1:1 face‐to‐face, audio‐taped, semistructured interviews were undertaken. The data were analysed using a framework approach, and this revealed four main themes: timing of disclosure; managing lived experience in learning environments; students’ coping mechanisms, and experience of support. Recommendations for practice was that approved education institutes (AEIs) should ensure they have a robust, inclusive practice by implementing strategies to develop these students’ resilience, and enhance their learning and the current support provisions. This will ensure the barriers to disclosing their mental health conditions are recognized and minimized to enable these students to fully contribute to their own learning and teaching experience.
Minimal clinically important difference (MCID) for work productivity and activity impairment (WPAI) questionnaire in psoriasis patients
Authors: Wu J.J. , Lin C. , Sun L. , Goldblum O. , Zbrozek A. , Burge R. , Augustin M. , Feldman S.R. 
Published: May 2018

AbstractBackgroundThe clinical meaningfulness of improvements in the Work Productivity and Activity Impairment Questionnaire for Psoriasis (WPAI‐PsO) reported by patients with psoriasis in response to treatment is unknown due to the lack of any publications that report minimal clinically importance differences (MCID) for WPAI‐PsO outcomes.ObjectiveTo determine the MCIDs for the work productivity loss and activity impairment domains of the Work Productivity and Activity Impairment Questionnaire for Psoriasis (WPAI‐PsO) using results from three Phase 3 trials of ixekizumab.MethodsMCIDs for WPAI‐PsO domains were derived using treatment agnostic data from patients participating in UNCOVER‐1/‐2/‐3. The analysis included patients randomized to placebo and two ixekizumab treatment groups (ixekizumab either every 2 weeks or 4 weeks) from the trials. WPAI‐PsO was administered at baseline and Week 12 for UNCOVER‐1/‐2/‐3 and at Weeks 24, 36, 52 and 60 in UNCOVER‐1/‐2. MCIDs for the WPAI‐PsO domains through Week 12 were derived using an anchor‐based method supplemented with the distribution‐based method. Anchors included 75%/90%/100% improvement in Psoriasis Area and Severity Index, Static Physicians Global Assessment (sPGA[0] and sPGA[0,1]) and Dermatology Life Quality Index MCID). MCIDs were triangulated using receiver operating characteristics (ROC) and distribution‐based methods.ResultsThe analyses included 3126 patients (Placebo: 792, Ixekizumab: 2334). All anchors were shown to be valid. Significant differences in the domains of WPAI‐PsO were observed between patients achieving clinically meaningful improvement in the validated anchors (all P‐values < 0.001). ROC analyses suggested a 20% improvement in the work productivity loss or activity impairment components best represented the benefit of meeting a clinical meaningful improvement in the validated anchors. The distribution‐based method supported the results of the anchor‐based method.ConclusionThe MCIDs for both the work productivity loss and the activity impairment domains of WPAI‐PsO were estimated to be 20% in patients with PsO.
The Real‐Time Properties of the Bank of Canada's Staff Output Gap Estimates
Authors: CHAMPAGNE JULIEN , POULIN‐BELLISLE GUILLAUME , SEKKEL RODRIGO 
Published: May 2018

AbstractWe study the revision properties of the Bank of Canada's staff output gap estimates since the mid‐1980s and show that the average revision has been significantly smaller since the early 2000s. Alternatively, revisions from econometric output gap estimates have not experienced a similar improvement. We show that the overestimation of potential output in real time following the 1991–92 recession explains the large revisions in the first half of the sample. Although Phillips‐curve inflation forecasts slightly worsen when conditioned on real time instead of final gaps, their relative poor performance reflects the general lack of inflation predictability rather than real‐time gap measurement issues.
Unconventional Monetary Policy and International Risk Premia
Authors: ROGERS JOHN H. , SCOTTI CHIARA , WRIGHT JONATHAN H. 
Published: May 2018

AbstractWe assess the relationship between monetary policy, foreign exchange risk premia, and term premia including the period at the zero lower bound (ZLB). We estimate a structural vector autoregression including U.S. and foreign interest rates and exchange rates and identify monetary policy shocks through a method that uses high‐frequency monetary policy surprises as the external instrument that achieves identification without using implausible restrictions. We split out effects of different types of monetary policy surprises that apply at the ZLB, including forward guidance and asset purchases. This allows us to measure the effects of policy shocks on expectations, and hence risk premia.
Damasio's error – Prosopagnosia with intact within‐category object recognition
Authors: Rossion Bruno 
Published: May 2018

The sudden inability to recognize individual faces following brain damage was first reported in a scientific journal 150 years ago and termed ‘prosopagnosia’ 70 years ago. While the term originally identified a face‐selective neurological condition, it is now obscured by a sequence of imprecisions. First, prosopagnosia is routinely used to define symptoms of individual face recognition (IFR) difficulties in the context of visual object agnosia or other neurological conditions, or even in the normal population. Second, this over‐expansive definition has lent support to a long‐standing within‐category recognition account of prosopagnosia, that is, that the impairment of IFR reflects a general impairment in recognizing within‐category objects. However, stringent experimental studies of classical cases of prosopagnosia following brain damage show that their core impairment is not in recognizing physically similar exemplars within non‐face object categories. Instead, the impairment presents specifically for recognizing exemplars of the category of faces. Moreover, compared to typical observers, the impairment appears even more severe for recognizing individual faces against physically dissimilar than similar distractors. Here, I argue that we need to limit accordingly our definition of prosopagnosia to a clinical (i.e., neurological) condition in which there is no basic‐level object recognition impairment. Other criteria for prosopagnosia are proposed, with the hope that this conservative definition enables the study of human IFR processes in isolation, and supports progress in understanding the nature of these processes.
Conservative surgery of uterine adenomyosis via laparoscopic versus laparotomic approach in a single institution
Authors: Kwack Jae Young , Im Kyong Shil , Kwon Yong‐Soon 
Published: May 2018

AbstractAimsTo evaluate the surgical outcomes of both approach methods (laparoscopy vs laparotomy) and to suggest the proper surgical approach according to type of uterine adenomyosis (focal vs diffuse).MethodsWe retrospectively analyzed 224 cases of uterine adenomyomectomy, 116 laparotomic and 108 laparoscopic, performed between July 2011 and June 2016 by a single surgeon (Y. S. K.). In all 224 cases, the surgeon had used transient occlusion of the uterine artery (TOUA). Surgical outcomes included weight of specimen, operating time, estimated blood loss and intraoperative injury to other organs. Postoperative clinical outcomes included symptom improvement (dysmenorrhea, menorrhagia and others) and recurrence.ResultsAll patients in the laparoscopic group had been diagnosed with focal uterine adenomyosis, and most in the laparotomic group (85.3%) had been diagnosed with diffuse type. The largest lesion diameters were 6.48 cm in the laparotomic group and 4.34 cm in the laparotomic group. Operation time and estimated blood loss were 116.12 min and 222.67 mL in the laparotomic group and 75.09 min, respectively, and 155.33 mL in the laparoscopic group. There was no case of laparotomic conversion in patients with laparoscopic adenomyomectomy.ConclusionConservative surgery is effective to reduce the symptoms of adenomyosis regardless of approach method. For near‐complete excision of adenomyosis, the diffuse type is recommended to be treated with laparotomic adenomyomectomy, and focal lesions less than 5 cm can be treated with laparoscopic conservative surgery.
Are Line Lengths Critical to the Discrimination of Axisymmetric Pairs of Figures from Disoriented Identical Pairs?
Authors: Kanbe Fumio 
Published: May 2018

AbstractI examined whether the lack of a difference in line lengths made the discrimination of axisymmetric (Ax) pairs of figures from disoriented identical (Idr) pairs difficult. Three basic pair types were prepared: Idr, Ax, and nonidentical/nonaxisymmetric (Nd) pairs. To avoid confusion arising from structural differences, all pairs of figures were set to be mutually isomorphic. Two figures of a pair were controlled to have the same line lengths of respective figural components (Experiment 1) or the same lengths of individual line segments (Experiment 2) in experiments where participants decided if the figures were the same/different. Experiment 1 showed longer latencies for Ax pairs than for Nd pairs, indicating that these feature values alone did not cause difficulty in discrimination. Experiment 2 showed that only Nd pairs with all line segments having the same lengths for the two figures had the same latencies as Ax pairs. The sameness of individual line segments in simple pairs of figures made discrimination difficult.
Aging‐ and vascular‐related pathologies
Authors: Wen Shu Wen , Wong Connie H. Y. 
Published: May 2018

AbstractOur aging population is set to grow considerably in the coming decades. In fact, the number of individuals older than 65 years will double by 2050. This projected increase in people living with extended life expectancy represents an inevitable upsurge in the presentation of age‐related pathologies. However, our current understanding of the impact of aging on a number of biological processes is unfortunately inadequate. Cardiovascular, cerebrovascular, and neurodegenerative diseases are particularly prevalent in the elderly population. Intriguingly, these pathologies are all associated with vascular dysfunction, suggesting that the process of aging can induce structural and functional impairments in vascular networks. Together with elevated cell senescence, pre‐existing comorbidities, and the emerging concept of age‐associated inflammatory imbalance, impaired vascular functions can significantly increase one's risk in acquiring age‐related diseases. In this short review, we highlight some current clinical and experimental evidence of how biological aging contributes to three vascular‐associated pathologies: atherosclerosis, stroke, and Alzheimer's disease.
Anterior restoration longevity among nursing facility residents: a 30‐year retrospective study
Authors: Ghazal Tariq S. , Cowen Howard J. , Caplan Daniel J. 
Published: May 2018

AbstractAimTo assess factors influencing anterior dental restoration longevity among the institutionalized elderly.MethodsAmong a sample of Eastern Iowa nursing facility dental patients, one anterior restoration placed from 1985 to 2014 was selected at random from each subject. Kaplan‐Meier survival curves were generated, with restoration failures defined as subsequent restorative codes involving the same surface; endodontic procedures; or extractions. Bivariate and multivariable Cox proportional hazards modeling were performed.ResultsIn multivariable analyses, the 1985 to 1999 cohort (n = 496) had longer restoration survival in in females < 75 years old versus males < 75 years old (P = 0.016), males ≥75 years old (P = 0.026) and females ≥75 years old (P = 0.030); one‐ versus three‐surface restorations (P < 0.001); and restorations placed by faculty/residents versus pre‐doctoral students (P = 0.009). The 2000 to 2014 cohort (n = 521) had longer restoration survival in females < 75 years old versus males ≥75 years old (P = 0.012) and females ≥75 years old (P = 0.019); residents who paid out‐of‐pocket versus those on Medicaid (P = 0.019); and composite resin versus glass ionomer cement restorations (P < 0.001).ConclusionsKnowing how long restorations last, and what factors affect their longevity, could improve treatment planning, informed consent, and communication with residents and caregivers, and also help inform practice guidelines for restorative care among the institutionalized elderly.
Infections in patients after Berlin Heart®EXCOR assist device implantation
Authors: Muñoz Patricia , Valerio Maricela , Vásquez Víctor , Velásquez‐Rodríguez Jesús , Sousa Iago , Zatarain Eduardo , Barrio José María , Ruiz Manuel , Cuerpo Gregorio , Rodríguez‐Abella Hugo , Hortal Javier , Bouza Emilio ,   the “Grupo de Apoyo al Manejo de las Asistencias Ventriculares” (GAMAV)
Published: May 2018

AbstractObjectivesBerlin Heart® EXCOR devices (BHED) are ventricular assist devices (VAD) used mainly as a bridge to heart transplantation (HT) in pediatric population. The aim of our study is to report the infections diagnosed in adult patients undergoing a BHED implantation.MethodsAdult patients receiving a BHED between Jul 2009 and Oct 2017 at our institution were included. Infections were classified according to the International Society of Heart and Lung Transplantation definitions in VAD‐Specific (VAD‐S), VAD‐Related (VAD‐R) and non‐VAD (N‐VAD).ResultsFifteen patients underwent BHED implantation, which was maintained for a mean of 92 (19‐195) days. Infection occurred in 13 patients who developed 36 infectious episodes: 5 VAD‐S (5 cannula infections); 8 VAD‐R (5 bloodstream infections and 3 mediastinitis) and 24 N‐VAD (7 urinary tract infections, 6 Cytomegalovirus diseases and others). Overall, 27 (75%) were bacterial, 7 (19.4%) were viral and there was one (2.7%) fungal infection. Eleven patients underwent HT and all of them developed at least one infection after it. In 3 cases, all VAD‐R or VAD‐S infections were caused by the same etiology as before HT. Their median time of appearance was on day +6 (3‐11) after BHED removal and HT. Overall mortality was 6/15 (40%). None of the deaths were related to VAD Infection.ConclusionsInfection complicated BHED implantation in 86.7% of the patients. Overall, 13.9% were specific of BHED and 22.2% were related. However, infections did not preclude HT in any case and carried no attributable mortality.
Complete Genome Sequence of Campylobacter fetus subsp. testudinum Strain 772, Isolated from Ascites of a Patient with Chronic Kidney Disease
Authors: Hou Shui-ping , He Peng , Zhou Yong , Wu Xin-wei 
Published: May 2018

ABSTRACT

Campylobacter fetus
subsp.
testudinum
originating in reptiles can cause invasive infections in humans. Here, we present the whole-genome sequence of
C. fetus
subsp.
testudinum
strain 772, isolated from a human patient in China.
Exploring the Microbiome of Callinectes sapidus (Maryland Blue Crab)
Authors: Ramachandran Padmini , Reed Elizabeth , Ottesen Andrea 
Published: May 2018

ABSTRACT

The Maryland blue crab (
Callinectes sapidus
) is a treasured food, especially in areas surrounding the Chesapeake Bay. It has huge economic impact on commerce, and thus, understanding the bacterial, fungal, and viral constituents of its microbiome provides valuable information to safely manage aquaculture, handling, and cooking of this valuable commodity.
Complete Genome Sequence of the Virulent Aeromonas salmonicida subsp. masoucida Strain RFAS1
Authors: Kim Ahran , Nguyen Thanh Luan , Kim Do-Hyung 
Published: May 2018

ABSTRACT

Here, we report the complete genome sequence of the pathogenic
Aeromonas salmonicida
subsp.
masoucida
strain RFAS1, isolated from black rockfish and showing signs of furunculosis. Sequencing with the PacBio platform yielded a circular chromosome of 4,783,004 bp and two plasmids (70,968 bp and 63,563 bp) harboring 4,411, 67, and 71 protein-coding genes, respectively.
Complete Genome Sequence of a Lumpy Skin Disease Virus Strain Isolated from the Skin of a Vaccinated Animal
Authors: Lojkić Ivana , Šimić Ivana , Krešić Nina , Bedeković Tomislav 
Published: May 2018

ABSTRACT
Vaccination of cattle against lumpy skin disease (LSD) can cause adverse reactions. Here, we report the first complete genome sequence of an LSD virus strain isolated from the skin of a vaccinated animal. We confirmed that the sequence of the virus used for vaccination remains stable.
Complete Genome Sequence of a Human Norovirus Strain from the United States Classified as Genotype GII.P6_GII.6
Authors: Chen Haifeng , Wang Shiliang , Wang Weimin 
Published: May 2018

ABSTRACT
We report here the complete genome sequence of a GII.6 norovirus strain detected in a clinical fecal specimen from the United States. The virus genome has a length of 7,547 bp and a GC content of 50.1%. Complete norovirus genotyping of the full-genome sequence identified the virus genotype as GII.P6_GII.6.
Image guided percutaneous spine procedures using an optical see-through head mounted display: proof of concept and rationale
Authors: Deib Gerard , Johnson Alex , Unberath Mathias , Yu Kevin , Andress Sebastian , Qian Long , Osgood Gregory , Navab Nassir , Hui Ferdinand , Gailloud Philippe 
Published: May 2018

Background and purposeOptical see-through head mounted displays (OST-HMDs) offer a mixed reality (MixR) experience with unhindered procedural site visualization during procedures using high resolution radiographic imaging. This technical note describes our preliminary experience with percutaneous spine procedures utilizing OST-HMD as an alternative to traditional angiography suite monitors.MethodsMixR visualization was achieved using the Microsoft HoloLens system. Various spine procedures (vertebroplasty, kyphoplasty, and percutaneous discectomy) were performed on a lumbar spine phantom with commercially available devices. The HMD created a real time MixR environment by superimposing virtual posteroanterior and lateral views onto the interventionalist’s field of view. The procedures were filmed from the operator’s perspective. Videos were reviewed to assess whether key anatomic landmarks and materials were reliably visualized. Dosimetry and procedural times were recorded. The operator completed a questionnaire following each procedure, detailing benefits, limitations, and visualization mode preferences.ResultsPercutaneous vertebroplasty, kyphoplasty, and discectomy procedures were successfully performed using OST-HMD image guidance on a lumbar spine phantom. Dosimetry and procedural time compared favorably with typical procedural times. Conventional and MixR visualization modes were equally effective in providing image guidance, with key anatomic landmarks and materials reliably visualized.ConclusionThis preliminary study demonstrates the feasibility of utilizing OST-HMDs for image guidance in interventional spine procedures. This novel visualization approach may serve as a valuable adjunct tool during minimally invasive percutaneous spine treatment.
Experimental investigation of forced convection heat transfer over horizontal tube with conical fins for different fin spacings and different inclination angles
Authors: Yakar Gülay 
Published: May 2018

This research was performed to experimentally study the heat transfer over a horizontal tube with conical fins for different fin spacings and different inclination angles. The air entering the test section first contacts the large surface of the conical fin. Therefore the conical fin both directs the air towards the heating surface and increases the heat transfer surface area. The experiments were conducted for three different inclination angles (45°, 60° and 80°) and three different fin spacings (10, 12, and 15 mm). Water and air were used as hot and cold fluid in these experiments, respectively. The water temperature, which was the heating fluid, was kept fixed at 65 °C. The cold fluid entered the test section at eight different air flow velocities (2–20 m/s). Experimental results indicated that the Nusselt number at each inclination angle for the 10 mm fin spacing was almost the same. Moreover, for the 15 mm fin spacing, the highest Nusselt number was obtained at 80° and lowest at 60° for Re > 5 × 104, while the Nusselt number was almost the same at each inclination angle for Re < 5 × 104. It was determined that the lowest pressure drop was obtained at 80° for both 10 and 15 mm.
Radium-223 Dichloride in Combination with Vascular Endothelial Growth Factor–Targeting Therapy in Advanced Renal Cell Carcinoma with Bone Metastases
Authors: McKay Rana R. , Bossé Dominick , Gray Kathryn P. , Michaelson M. Dror , Krajewski Katherine , Jacene Heather A. , Walsh Meghara , Bellmunt Joaquim , Pomerantz Mark , Harshman Lauren C. , Choueiri Toni K. 
Published: May 2018

Abstract
Purpose: This study investigates the biologic activity of radium-223 with VEGF-targeted therapy in patients with advanced renal cell carcinoma (aRCC) and bone metastases.
Patients and Methods: Fifteen treatment-naïve patients (n = 15) received pazopanib 800 mg orally once daily, and 15 previously treated patients received sorafenib 400 mg orally twice daily. Radium-223 55 kilobecquerel/kg was administered concurrently every 4 weeks for up to six infusions in both cohorts. The primary endpoint was decline in bone turnover markers (Procollagen I Intact N-Terminal, N-telopeptide, C-telopeptide, osteocalcin, and bone-specific alkaline phosphatase) compared with baseline. Secondary endpoints included safety, rate of symptomatic skeletal event (SSE) and time to first SSE, objective response rate, change in analgesic use, and quality of life. Exploratory analysis of tumor genomic alterations was performed.
Results: Of the 30 patients enrolled, 83% had IMDC intermediate- or poor-risk disease, 33% had liver metastases, and 83% had a history of SSE prior to enrollment. No dose-limiting toxicity was observed. All bone turnover markers significantly declined from baseline at week 8 and 16. Forty percent of patients experienced treatment-related grade ≥3 adverse events. Response rates were 15% and 18% per RECIST v1.1 and bone response was 50% and 30% per MD Anderson criteria, in the pazopanib and sorafenib cohort, respectively. Median SSE-free interval was 5.8 months and not reached, respectively. Analgesic use remained stable over the study time.
Conclusions: Radium-223 combined with VEGF-targeted therapy is biologically active and safe. Randomized-controlled trials are needed to define the role of radium-223 in aRCC with skeletal metastases. Clin Cancer Res; 24(17); 4081–8. ©2018 AACR.