bluuebunny/crossref_metadata_2025_split huggingface dataset:
Increased Serum Netrin-1 Is Associated With Improved Prognosis of Ischemic Stroke
Authors: Guo Daoxia , Zhu Zhengbao , Zhong Chongke , Peng Hao , Wang Aili , Xu Tian , Peng Yanbo , Xu Tan , Chen Chung-Shiuan , Li Qunwei , Ju Zhong , Geng Deqin , Chen Jing , Zhang Yonghong , He Jiang 
Published: March 2019

Background and Purpose—
Previous experimental studies suggested that serum netrin-1 was associated with the progression of ischemic stroke. Knowledge about netrin-1 among ischemic stroke patients may provide new ideas for the prognostic assessment of ischemic stroke. The aim of this study was to investigate the association between serum netrin-1 and prognosis of ischemic stroke.

Methods—
Serum netrin-1 levels at baseline were measured for 3346 ischemic stroke patients from the CATIS (China Antihypertensive Trial in Acute Ischemic Stroke), and all patients were followed up at 3 months after stroke onset. The primary outcome was a combination of death and major disability (modified Rankin Scale score of ≥3) within 3 months after stroke onset.

Results—

Up to 3 months after stroke onset, 845 patients (25.25%) experienced death or major disability. After adjustment for baseline National Institutes of Health Stroke Scale score and other potential confounders, elevated serum netrin-1 was associated with a decreased risk of primary outcome (odds ratio, 0.65; 95% CI, 0.47–0.88;
P
trend
=0.002) when 2 extreme quartiles were compared. Each SD increase of log-transformed netrin-1 was associated with 17% (95% CI, 7%–26%) decreased risk of primary outcome. Multivariable-adjusted spline regression models showed a negative linear dose-response relationship between serum netrin-1 and the risk of primary outcome (
P
linearity
=0.003). Adding netrin-1 quartile to a model containing conventional risk factors improved risk prediction for primary outcome (net reclassification improvement index =14.74%;
P
=0.002; integrated discrimination improvement =0.40%;
P
=0.005).

Conclusions—
Elevated serum netrin-1 levels were associated with improved prognosis at 3 months after ischemic stroke, suggesting that serum netrin-1 may be a potential prognostic biomarker for ischemic stroke. Further studies from other samples of ischemic stroke patients are needed to replicate our findings and to clarify the potential mechanisms.

Clinical Trial Registration—

URL:
https://www.clinicaltrials.gov
. Unique identifier: NCT01840072.
On the Long-Wavelength Validation of the SWOT KaRIn Measurement
Authors: Wang Jinbo , Fu Lee-Lueng 
Published: March 2019

AbstractThe Surface Water and Ocean Topography (SWOT) mission will measure the sea surface height (SSH) using a Ka-band radar interferometer (KaRIn) over a swath off the nadir of the satellite tracks. The mission requires calibration and validation (CalVal) of the SSH wavenumber spectrum at wavelengths between 15 and 1000 km. The CalVal in the short-wavelength range (15–150 km) requires in situ observations. In the long-wavelength range (150–1000 km), the CalVal will use the onboard Jason-class nadir altimeter. Using a high-resolution global ocean simulation, this study identifies the spatial scales beyond which the nadir and off-nadir observations can be considered comparable. Our results suggest that the ocean signals at nadir can represent off-nadir ocean signals at wavelengths longer than 120 and 70 km along the midswath and the inner edge of the KaRIn grid, respectively, indicating that the nadir altimeter is able to fulfill its goal to validate the long-wavelength KaRIn measurement. The wavelength along the inner edge is limited around 70 km because the onboard nadir altimeter cannot resolve spatial scales longer than ~70 km. These wavelengths provide a reference point for the required spatial coverage of the SWOT SSH in situ CalVal.
Aircraft Icing Study Using Integrated Observations and Model Data
Authors: Boudala Faisal , Isaac George A. , Wu Di 
Published: March 2019

Abstract
Light (LGT) to moderate (MOD) aircraft icing (AI) is frequently reported at Cold Lake, Alberta, but forecasting AI has been a big challenge. The purpose of this study is to investigate and understand the weather conditions associated with AI based on observations in order to improve the icing forecast. To achieve this goal, Environment and Climate Change Canada in cooperation with the Department of National Defence deployed a number of ground-based instruments that include a microwave radiometer, a ceilometer, disdrometers, and conventional present weather sensors at the Cold Lake airport (CYOD). A number of pilot reports (PIREPs) of icing at Cold Lake during the 2016/17 winter period and associated observation data are examined. Most of the AI events were LGT (76%) followed by MOD (20%) and occurred during landing and takeoff at relatively warm temperatures. Two AI intensity algorithms have been tested based on an ice accumulation rate (IAR) assuming a cylindrical shape moving with airspeed υa of 60 and 89.4 m s−1, and the Canadian numerical weather prediction model forecasts. It was found that the algorithms IAR2 with υa = 89.4 m s−1 and IAR1 with υa = 60 m s−1 underestimated (overestimated) the LGT (MOD) icing events, respectively. The algorithm IAR2 with υa = 60 m s−1 appeared to be more suitable for forecasting LGT icing. Over all, the hit rate score was 0.33 for the 1200 UTC model run and 0.6 for 0000 UTC run for both algorithms, but based on the individual icing intensity scores, the IAR2 did better than IAR1 for forecasting LGT icing events.
Managing pharmaceutical shortages: an overview and classification of policy responses in Europe and the USA
Authors: Beck Matthias , Buckley Joan , O’Reilly Seamus 
Published: March 2019

This exploratory article gives a cross-sectional account of how established health-care systems have responded to the novel challenge of drug shortages. In line with previous research, our analysis confirms the existence of strong path dependence in the adoption of policy responses. This path dependence is manifested in a pronounced typology of response patterns where jurisdictional approaches to the management of drug shortages differ along two core dimensions. These are the salience attributed to the problem, and the level to which state organisations engage with the problem. These patterns are mirrored in the conceptual framing and strategic orientation of the respective drug shortage policies, with: Spanish and Irish drug shortage policies focusing on the individual product level and being largely reactive; US policies focusing on the therapeutic level, with a focus on mitigation; and German and Austrian policies seeking to address the active ingredient level, with a proactive focus on shortage prevention. Despite the importance of legacies, we find evidence of innovation and path creation particularly in relation to the US and German approaches, which we explain by the simultaneous occurrence of internal crisis and pressures from local stakeholders. Points for practitioners This article addresses a major challenge, drug shortages, which has emerged in recent years and could be characterised as a ‘system shock’. A typology of policies adopted based on an analysis of a range of health system responses is developed. Fundamental differences across these responses are evident, such as level of action (individual product level/therapeutic level/active ingredient level), time frame (from ad hoc/short term to long term) and strategic approach (reactive/mitigating/preventive). This analysis finds fundamentally different policies, such as delegated institutional powers and census management/network governance. The typology based on the salience attributed to the problem and the nature (proactive/reactive) of policymaking may assist stakeholders in health systems to critique their approach to this challenge and, at a more fundamental level, how the system responds to disruptive events.
A systematic review and critical appraisal of quality indicators to assess optimal palliative care for older people with dementia
Authors: Amador Sarah , Sampson Elizabeth L , Goodman Claire , Robinson Louise ,   SEED Research Team
Published: March 2019

Background: A challenge for commissioners and providers of end-of-life care in dementia is to translate recommendations for good or effective care into quality indicators that inform service development and evaluation. Aim: To identify and critically evaluate quality indicators for end-of-life care in dementia. Results: We found 8657 references, after de-duplication. In all, 19 publications describing 10 new and 3 updated sets of indicators were included in this review. Ultimately, 246 individual indicators were identified as being relevant to dementia end-of-life care and mapped against EAPC guidelines. Conclusions: We systematically derived and assessed a set of quality indicators using a robust framework that provides clear definitions of aspects of palliative care, which are dementia specific, and strengthens the theoretical underpinning of new complex interventions in end-of-life care in dementia.
Return to Sport After Arthroscopic Rotator Cuff Repair: Is There a Difference Between the Recreational and the Competitive Athlete?
Authors: Altintas Burak , Anderson Nicole , Dornan Grant J. , Boykin Robert E. , Logan Catherine , Millett Peter J. 
Published: March 2019

Background: Return to sport (RTS) remains an important challenge and measure of success for athletes undergoing arthroscopic rotator cuff repair (RCR). Purpose: To determine the rate of RTS after RCR and to analyze predictive factors associated with a lower rate of return. Study Design: Systematic review and meta-analysis. Methods: A systematic review of the literature was performed following the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines. The electronic databases of PubMed, MEDLINE, Cochrane, and Google Scholar were used for the literature search. Study quality was evaluated according to the Coleman Methodology Score. Studies in English evaluating RTS after arthroscopic repair of partial- or full-thickness rotator cuff tears among athletes of all levels, ages, and sports were included. Random effects meta-analysis and metaregression were performed to investigate RTS activity rate after arthroscopic RCR and to explore study heterogeneity, respectively. Results: Fifteen studies were reviewed, including 486 patients (499 shoulders) who were treated with arthroscopic RCR and who had a mean follow-up of 40.1 months (range, 18-74.4 months). Eighteen patients were lost to follow-up, leaving 468 patients with outcome data; 347 identified themselves as athletes (81 competitive, 266 recreational). The most commonly included sports were baseball (n = 45), golf (n = 38), football (n = 23), and tennis (n = 18). RTS specific to the type of athlete was reported for 299 of 347 athletes. According to the meta-analysis, the overall rate of RTS at a similar level of play or higher was 70.2%, with 73.3% of recreational athletes and 61.5% of competitive athletes able to return. A subset of 43 baseball and softball players across 4 studies yielded a 79% rate of RTS; however, only 38% returned to the same level of play or higher. Subgroup meta-analysis revealed no significant difference in the rate of RTS between competitive and recreational athletes. Metaregression analysis revealed that the mean follow-up time and mean age at surgery were not significantly associated with RTS rate. Conclusion: Most athletes (70.2%) were able to return to a preinjury level of play after arthroscopic RCR. While recreational sports participation (73.3%) was associated with higher return, competitive sports (61.5%) and overhead sports (38%) were associated with lower return. Exactly why all athletes do not return remains uncertain and likely multifactorial.
L’appropriabilité : essai de théorisation sur le rôle de l’appropriation dans le processus d’achat d’occasion
Authors: Dehling Aurélie , Vernette Eric 
Published: March 2019

Résumé Cet article propose un essai de théorisation sur le rôle de l’appropriation dans le processus d’achat d’occasion. Il fait émerger le concept d’ appropriabilité, défini comme le potentiel plus ou moins élevé d’un objet à devenir la possession pleine et entière d’un consommateur. La définition de ce potentiel dépend de la prégnance de la trace du/des précédent(s) propriétaire(s) et de la nature de la motivation qui a conduit à se le procurer. Les deux séquences du processus d’appropriation d’un objet d’occasion seront définies par ce potentiel : (1) la mise à distance, dont l’intensité varie selon la prégnance de la trace de l’autre et (2) la mise en soi, dont les stratégies – le déni, la créativité ou la maîtrise – dépendent de la nature de la motivation d’achat.
Evaluation of a Computerized Insulin Dosing Tool for the Treatment of Diabetic Ketoacidosis
Authors: Defayette Aubrey A. , Voigt Lisa M. , Zammit Kimberly T. , Nadler Jamie N. , Kersten Brian P. 
Published: March 2019

Purpose: Computerized insulin dosing tools (CIDT) have been shown to improve the care of critically ill patients with hyperglycemia. Application of a CIDT in addition to a diabetic ketoacidosis (DKA) order set for the treatment of DKA has not been evaluated. Our goal was to determine the effects the CIDT would have on the treatment of a patient with DKA. Methods: In this retrospective, pre–post chart review, a provider-driven insulin dosing strategy (pregroup) was compared to the CIDT (postgroup) with 24-hour pharmacist monitoring. The CIDT utilized an equation that incorporated a patient’s most recent blood glucose (BG) value and recommended a rate of insulin (units/hour) every hour. Results: All baseline characterizes were similar between the 2 groups. There were no significant differences in average time to anion gap closure (≤ 12 mEq/L) or intensive care unit length of stay between the pregroup and postgroup (12.5 [6] hours vs 10.5 [7] hours, P = 0.235; 40.6 [24] hours vs 40.8 [24] hours, P = 0.945). Although not statistically significant, 17 hypoglycemic events (BG < 70 mg/dL) occurred in the pregroup with 4 being severe (BG < 50 mg/dL) while 5 hypoglycemic events occurred in the postgroup, none of which were severe. Conclusion: This study suggests, when compared to a provider-driven insulin dosing strategy, the CIDT with 24-hour pharmacist monitoring is efficacious and safe for treatment of patients with a primary diagnosis of DKA.
Acupuncture protects the interstitial cells of Cajal by regulating miR-222 in a rat model of post-operative ileus
Authors: Deng Jing-jing , Lai Ming-yin , Tan Xinghua , Yuan Qing 
Published: March 2019

Background: Recovery of the interstitial cells of Cajal (ICCs) during post-operative ileus (POI) is important for the restoration of gastrointestinal (GI) motility. Acupuncture can protect ICCs, but the underlying mechanisms remain unclear. In this study, we investigated whether miR-222, c-kit and endothelial nitric oxide synthase (eNOS) are involved in the putative effects of acupuncture on ICC recovery. Methods: A POI model was established in Sprague-Dawley rats by colo-colic anastomosis, and then acupuncture was performed at bilateral ST36, SP6 and LR3 once daily for 3 consecutive days. C-kit protein expression in the colonic tissue adjacent to the incision site was determined by immunohistochemistry and Western blotting. mRNA levels of c-kit, eNOS and miR-222 were measured by real-time polymerase chain reaction (RT-PCR). Results: The levels of c-kit mRNA/protein and eNOS mRNA decreased, while miR-222 increased in the colonic tissues of POI model rats. Acupuncture treatment improved GI motility, inhibited the up-regulation of miR-222 and blocked the down-regulation of c-kit mRNA/protein and eNOS mRNA. The levels of miR-222 and c-kit were negatively correlated. Conclusion: Acupuncture at ST36, SP6 and LR3 facilitates ICC recovery and improves post-operative GI motility in part through regulation of miR-222, c-kit and eNOS.
Burnout and distress in Australian physician trainees: Evaluation of a wellbeing workshop
Authors: Axisa Carmen , Nash Louise , Kelly Patrick , Willcock Simon 
Published: March 2019

Objective: To evaluate the effectiveness of a workshop intervention to promote wellbeing for Australian physician trainees using a randomized-controlled design. Methods: Participants were randomly assigned into intervention and control groups. The intervention group attended a half-day workshop. Outcome measures included depression anxiety stress scale, professional quality of life scale and alcohol use disorders identification test. Demographic and work/life factors were measured. Measurements were recorded at baseline, 3 and 6 months, and the workshop was evaluated by participants. Results: High rates of burnout (76%) and secondary traumatic stress (91%) were detected among study participants and around half met screening criteria for depression (52%), anxiety (46%) and stress (50%) at baseline. Workshop evaluations showed that participants agreed that the training was relevant to their needs (96%) and met their expectations (92%). There was a small reduction in alcohol use, depression and burnout in the intervention group compared with the control group at 6 months, but these changes did not reach statistical significance. Conclusion: High rates of psychological morbidity detected in the study suggest that physician trainees are a vulnerable group who may benefit from initiatives that promote wellbeing and changes in the workplace to reduce distress.
Neuroprotective effects of topical coenzyme Q10 + vitamin E in mechanic optic nerve injury model
Authors: Ekicier Acar Selcan , Sarıcaoğlu M Sinan , Çolak Aysel , Aktaş Zeynep , Sepici Dinçel Aylin 
Published: March 2019

Purpose: We aimed to create mechanic optic nerve injury model in rats and investigate the neuroprotective effects of topical Coenzyme Q10 + Vitamin E (CoQ + Vit.E) molecules on retinal ganglion cells. Methods: Mechanic optic nerve injury model was created in the right eyes of rats (n = 12). Rats were divided into two groups: glaucoma model with sham treatment and topical CoQ + Vit.E treatment. Treatment was applied for 4 weeks. Glial fibrillary acidic protein, Brn-3a antibody, and anti-Iba1 were examined by immunohistochemistry. Glial fibrillary acidic protein, Bax, Bcl-xL, and Tfam protein expression were measured by Western blot analysis. Results: The number of Brn-3a-positive retinal ganglion cell was 15.0 ± 1.0 (min: 14, max: 16) in sham treatment group and 22.2 ± 4.8 (min: 18, max: 29) in topical CoQ10 + Vit.E treatment group. The protection of Brn-3a in CoQ10 + Vit.E was statistically significant (p < 0.05). Glial fibrillary acidic protein–positive astroglial counts were recorded as 11.7 ± 2.1 (min: 10, max: 14) in sham treatment and 2.5 ± 1.5 (min: 1, max: 4) in topical CoQ10 + Vit.E treatment group (p < 0.05). Topical CoQ10 + Vit.E treatment also decreased Iba1 expression in the retina of mechanic optic nerve injury groups. CoQ10 + Vit.E treatment prevented apoptotic cell death by increasing Bcl-xL protein expression. Also, CoQ10 + Vit.E preserved Tfam protein expression in the retina. Conclusion: This study has shown that in glaucoma treatment the neuron protecting effect of topical CoQ10 + Vit.E molecules can be valuable.
Checklist for the Systemic Treatment of Psoriasis Using Biologics: A Delphi Study
Authors: Fahim Christine , Kim Ben Whan , Bourcier Marc , Glassman Steven , Gooderham Melinda , Guenther Lyn , Gulliver Wayne , Lynde Charles , Poulin Yves , Pratt Melanie , Shear Neil , Vender Ronald , Walsh Scott , Fahim Simone 
Published: March 2019

Background: Despite the complexity of psoriasis treatment using biologic therapy, there does not exist a standardized synoptic reporting form for the initiation of this population. The purpose of this study was to use a modified Delphi approach to develop a standard checklist for the standardized documentation of patients receiving systemic biologic therapy for psoriasis. Methods: A modified Delphi survey was conducted over 3 rounds (February 2017 through January 2018). An expert panel generated a 51-item checklist that was proposed to participants. Items were rated on an anchored 1-7 Likert scale. Consensus was defined apriori as ≥ 70% agreement by respondents. Results: A total of 58, 17, and 18 dermatologists participated in 3 consecutive Delphi rounds, respectively. Only half of the dermatologists surveyed reported using a checklist for the management of psoriasis. The final checklist comprised 19, 5, 6, and 9 items pertaining to patient history; physical exam and history of systemic therapy; vaccinations; and lab investigations and bloodwork, respectively. Conclusions: Given the increasing availability and complexity of biologic agents for psoriasis treatment, there is a need to promote standardized documentation for this population. The Checklist for the Systemic Treatment of Psoriasis presents 38 items that should be considered when initiating patients with psoriasis on biologic therapy.
Angiotensin-converting enzyme insertion/deletion polymorphism and susceptibility to Henoch–Schönlein purpura: a meta-analysis
Authors: Zhang Xiaoqing , Wu Lin , Chai Minglei , Huang Xiaofang , Zhu Jiajin , Li Shaojun , Zhang Jun , Zhang Huahong 
Published: March 2019

Objective: Meta-analysis was performed in the current study to evaluate the relationship of the angiotensin-converting enzyme insertion/deletion polymorphism with the risk of the incidence of Henoch–Schönlein purpura. Methods: The electronic databases, including Embase, PubMed and Google scholar, were systemically retrieved to search for related articles. Meanwhile, statistical analysis was performed using the odds ratio and the corresponding 95% confidence interval. Results: A total of six articles enrolling 504 patients and 706 healthy controls was enrolled into the current meta-analysis. Results of the meta-analysis suggested that the angiotensin-converting enzyme D allele was markedly correlated with the risk of the incidence of Henoch–Schönlein purpura among the general population (deletion (D) vs. insertion (I): odds ratio (OR) 1.42, 95% confidence interval (CI) 1.05–1.93; DD vs. II: OR 2.23, 95% CI 1.06–4.70; DI vs. II: OR 1.36, 95% CI 1.00–1.85; dominant model: OR 1.56, 95% CI 1.00–2.42; recessive model: OR 1.83, 95% CI 1.06–3.16). Moreover, such a polymorphism was found to correlate with the susceptibility to Henoch–Schönlein purpura when studies were stratified according to the sample size of over 200. In addition, such a polymorphism was recognised to be remarkably associated with the susceptibility to Henoch–Schönlein purpura in the Caucasian population, which was not found in the Asian population. Conclusions: The results of the current meta-analysis indicate that the angiotensin-converting enzyme D allele might be a risk factor against the risk of Henoch–Schönlein purpura, especially in Caucasians.