bluuebunny/crossref_metadata_2025_split huggingface dataset:
Influence of ocular dominance columns and patchy callosal connections on binocularity in lateral striate cortex: Long Evans versus albino rats
Authors: Andelin Adrian K. , Doyle Zane , Laing Robyn J. , Turecek Josef , Lin Baihan , Olavarria Jaime F. 
Published: October 2019

AbstractIn albino rats, it has been reported that lateral striate cortex (V1) is highly binocular, and that input from the ipsilateral eye to this region comes through the callosum. In contrast, in Long Evans rats, this region is nearly exclusively dominated by the contralateral eye even though it is richly innervated by the callosum (Laing, Turecek, Takahata, & Olavarria, 2015). We hypothesized that the inability of callosal connections to relay ipsilateral eye input to lateral V1 in Long Evans rats is a consequence of the existence of ocular dominance columns (ODCs), and of callosal patches in register with ipsilateral ODCs in the binocular region of V1 (Laing et al., 2015). We therefore predicted that in albino rats input from both eyes intermix in the binocular region, without segregating into ODCs, and that callosal connections are not patchy. Confirming our predictions, we found that inputs from both eyes, studied with the transneuronal tracer WGA‐HRP, are intermixed in the binocular zone of albinos, without segregating into ODCs. Similarly, we found that callosal connections in albino rats are not patchy but instead are distributed homogeneously throughout the callosal region in V1. We propose that these changes allow the transcallosal passage of ipsilateral eye input to lateral striate cortex, increasing its binocularity. Thus, the binocular region in V1 of albino rats includes lateral striate cortex, being therefore about 25% larger in area than the binocular region in Long Evans rats. Our findings provide insight on the role of callosal connections in generating binocular cells.
Tunable methacrylated hyaluronic acid‐based hydrogels as scaffolds for soft tissue engineering applications
Authors: Spearman Benjamin S. , Agrawal Nikunj K. , Rubiano Andrés , Simmons Chelsey S. , Mobini Sahba , Schmidt Christine E. 
Published: October 2019

AbstractHyaluronic acid (HA)‐based biomaterials have been explored for a number of applications in biomedical engineering, particularly as tissue regeneration scaffolds. Crosslinked forms of HA are more robust and provide tunable mechanical properties and degradation rates that are critical in regenerative medicine; however, crosslinking modalities reported in the literature vary and there are few comparisons of different scaffold properties for various crosslinking approaches. In this study, we offer direct comparison of two methacrylation techniques for HA (glycidyl methacrylate HA [GMHA] or methacrylic anhydride HA [MAHA]). The two methods for methacrylating HA provide degrees of methacrylation ranging from 2.4 to 86%, reflecting a wider range of properties than is possible using only a single methacrylation technique. We have also characterized mechanical properties for nine different tissues isolated from rat (ranging from lung at the softest to muscle at the stiffest) using indentation techniques and show that we can match the full range of mechanical properties (0.35–6.13 kPa) using either GMHA or MAHA. To illustrate utility for neural tissue engineering applications, functional hydrogels with adhesive proteins (either GMHA or MAHA base hydrogels with collagen I and laminin) were designed with effective moduli mechanically matched to rat sciatic nerve (2.47 ± 0.31 kPa). We demonstrated ability of these hydrogels to support three‐dimensional axonal elongation from dorsal root ganglia cultures. Overall, we have shown that methacrylated HA provides a tunable platform with a wide range of properties for use in soft tissue engineering.
Poly(ε‐caprolactone)/keratin/heparin/VEGF biocomposite mats for vascular tissue engineering
Authors: Wan Xiuzhen , Li Pengfei , Jin Xingxing , Su Fu , Shen Jian , Yuan Jiang 
Published: October 2019

AbstractVascular endothelial growth factor (VEGF) is an effective growth and angiogenic cytokine, which stimulates proliferation and survival of endothelial cells, and promotes angiogenesis and vascular permeability. Binding VEGF with heparin could protect it from rapid degradation, subsequently allowing it to be controlled release. Primarily, poly(ε‐caprolactone) (PCL) and keratin were coelectrospun, followed by conjugating with heparin and subsequently binding VEGF. The loaded heparin and VEGF on these mats were quantified, respectively. The surface characteristics of mats were investigated by scanning electron microscopy (SEM) and X‐ray photoelectron spectroscopy (XPS). The VEGF delivery results indicated these mats could sustainably release VEGF for 2 weeks. Cell viability assays suggested these mats were valid to accelerate human umbilical vein endothelial cells (HUVECs) proliferation, while inhibit human umbilical arterial smooth muscle cells (HUASMCs) growth under the combined actions of VEGF and heparin. The results tested by blood clotting times (APTT, PT, and TT), hemolysis, and platelet adhesion indicated the mats were blood compatible. To sum up, these biocomposite mats are ideal scaffolds for vascular tissue engineering.
Clinical Effects of a Pectin‐Containing Oligomeric Formula in Tube Feeding Patients: A Multicenter Randomized Clinical Trial
Authors: Maruyama Michio , Goshi Satoshi , Kashima Yasushige , Mizuhara Akihiro , Higashiguchi Takashi 
Published: October 2019

AbstractBackgroundA pectin‐containing oligomeric formula (POF) is a unique type of enteral formula that transforms from a liquid to a gel after reacting with gastric acid. Reports on its clinical effects have been limited. The present study was conducted to examine and verify the clinical effects of POF.MethodsThe study subjects were 201 stable patients receiving intragastric tube feeding. They were randomized into 2 groups to receive either POF or a standard polymeric formula (SPF) as a control. The duration of observation was 1 week. Analyses were conducted for the incidence of predefined composite events, including diarrhea, defecation treatments, and other enteral nutrition (EN) management–related events.ResultsComposite events occurred in 15 of 98 patients in the POF group and 30 of 100 patients in the SPF group, with a significantly lower incidence in the POF group compared with the SPF group (P = 0.011). In particular, diarrhea occurred in 2 patients in the POF group and 13 patients in the SPF group, with a significantly lower incidence in the POF group compared with the SPF group (P = 0.003).ConclusionsThe results of this study suggest that POF is less likely to cause EN‐related events, especially diarrhea, than SPF is.
“A Geo-ontological Thump”: Ontological Instability and the Folding City in Mikko Rimminen’s Early Prose
Authors: Ameel Lieven 
Published: October 2019

AbstractThis chapter examines ontological instability in terms of Deleuze’s concept of the fold in the early prose texts of Finnish author Mikko Rimminen: The Tipplers’ Novel (2004), Woodblock (2007), and “An Extract from a Manuscript” (2009). The focus is on how the relationship between the fictional city and its referential counterpart is foregrounded as well as undermined in a way that destabilizes the ontological status of the storyworlds. Key concepts used in the analysis of the literary space and storyworld are Brian McHale’s “flickering effect” and Bertrand Westphal’s “heterotopic interference.” Deleuze’s “fold” is proposed as a heuristic concept to describe how ontological instability in postmodern storyworlds is shaped. This chapter proposes a reading of Rimminen’s prose from the perspective of apocalyptic undercurrents, which have remained largely unappreciated.
Uncanny Spaces of Transformation: Fabulations of the Forest in Finland-Swedish Prose
Authors: Kurikka Kaisa 
Published: October 2019

AbstractThis chapter argues that recent Finland-Swedish prose fiction invests in describing the forest as a space of affective encounters between human and non-human creatures. It also argues that the forest is a space of transformation, in which the forest itself and also the various creatures which inhabit it undergo a process of metamorphosis. The forests of the late modern era appear as uncanny spaces that express the experience of estrangement typical of late modernity. By drawing on the geophilosophical concepts of Gilles Deleuze and Félix Guattari, such as re- and deterritorialization and smooth and striated space, the chapter discusses prose fiction written by Kaj Korkea-aho, Johanna Holmström, and Henrika Ringbom.
The Miracle of the Mesh: Global Imaginary and Ecological Thinking in Ralf Andtbacka’s Wunderkammer
Authors: Malmio Kristina 
Published: October 2019

AbstractThis chapter studies the spatial politics of Wunderkammer, a postmodernist collection of poetry. It focuses on how the cabinet of curiosities and the Chinese box, two traditional, limited spatial forms, in Wunderkammer become a means to global imaginary and ecological thinking. By drawing on the ideas of Timothy Morton, the chapter argues that the radical interconnectedness of the objects depicted is a textual representation of mesh. The analysis shows how containers and boxes turn into open and porous spaces, places become strange, and global space grows into junkspace. Finally, it argues that the collection turns away from the globe, apprehended as a financial-technocratic system, toward the world ecology of the planet.
“Never Give Up Hopelessness!?”: Emotions and Spatiality in Contemporary Finnish Experimental Poetry
Authors: Helle Anna 
Published: October 2019

AbstractThis chapter focuses on contemporary Finnish experimental poetry written by Karri Kokko, Tytti Heikkinen, and Eino Santanen. The poems are approached from the viewpoint of the politics of emotion and spatiality, and in the context of late modernity. The aim is to figure out how new Finnish poetry deals with the surrounding society.In this chapter, spatiality refers to Finland as a geographical place and cultural area, and to Finnish literature as a public space in which emotional and political topics are experienced and dealt with. The poems play with the notions of public and intimate spaces in various ways. Negative emotions have an important role in these poems, and this is related to how the poems deal with the problems of present-day Finnish society.
Multivariate data analysis of capacitance frequency scanning for online monitoring of viable cell concentrations in small-scale bioreactors
Authors: Metze Sabrina , Blioch Stefanie , Matuszczyk Jens , Greller Gerhard , Grimm Christian , Scholz Jochen , Hoehse Marek 
Published: October 2019

AbstractViable cell concentration (VCC) is one of the most important process attributes during mammalian cell cultivations. Current state-of-the-art measurements of VCC comprise offline methods which do not allow for continuous process data. According to the FDA’s process analytical technology initiative, process monitoring and control should be applied to gain process understanding and to ensure high product quality. In this work, the use of an inline capacitance probe to monitor online VCCs of a mammalian CHO cell culture process in small-scale bioreactors (250 mL) was investigated. Capacitance sensors using single frequency are increasingly common for biomass monitoring. However, the single-frequency signal corresponds to the cell polarization that represents the viable cell volume. Therefore single-frequency measurements are dependent on cell diameter changes. Measuring the capacitance across various frequencies (frequency scanning) can provide information about the VCC and cope with changing cell diameter. Applying multivariate data analysis on the frequency scanning data successfully enabled direct online monitoring of VCCs in this study. The multivariate model was trained with data from 5 standard cultivations. The model provided a prediction of VCCs with relative errors from 5.5 to 11%, which is a good agreement with the acceptance criterion based on the offline reference method accuracy (approximately 10% relative error) and strongly improved compared with single-frequency results (16 to 23% relative error). Furthermore, robustness trials were conducted to demonstrate the model’s predictive ability under challenging conditions. The process deviations in regard to dilution steps and feed variations were detected immediately in the online prediction of the VCC with relative errors between 6.7 and 13.2%. Thus in summary, the presented method on capacitance frequency scanning demonstrates its suitability for process monitoring and control that can save batches, time, and cost.
Regularity of Dirac-harmonic maps with $$\lambda $$-curvature term in higher dimensions
Authors: Jost Jürgen , Liu Lei , Zhu Miaomiao 
Published: October 2019

AbstractIn this paper, we will study the partial regularity for stationary Dirac-harmonic maps with$$\lambda $$λ-curvature term. For a weakly stationary Dirac-harmonic map with$$\lambda $$λ-curvature term$$(\phi ,\psi )$$(ϕ,ψ)from a smooth bounded open domain$$\Omega \subset {\mathbb {R}}^m$$Ω⊂Rmwith$$m\ge 2$$m≥2to a compact Riemannian manifoldN, if$$\psi \in W^{1,p}(\Omega )$$ψ∈W1,p(Ω)for some$$p>\frac{2m}{3}$$p>2m3, we prove that$$(\phi , \psi )$$(ϕ,ψ)is smooth outside a closed singular set whose$$(m-2)$$(m-2)-dimensional Hausdorff measure is zero. Furthermore, if the target manifoldNdoes not admit any harmonic sphere$$S^l$$Sl,$$l=2,\ldots , m-1$$l=2,…,m-1, then$$(\phi ,\psi )$$(ϕ,ψ)is smooth.
Performance Tests of Smart City IoT Data Repositories for Universal Linear Infrastructure Data and Graph Databases
Authors: Gorawski Michał , Grochla Krzysztof 
Published: October 2019

AbstractThe infrastructure managed by Smart City systems includes mainly linear structures, such as pipelines, electric power lines, railway lines, etc.. In this paper, we propose the transcription of linear infrastructure to graph representation and storing needed meta-data in a graph database, merged with the traditional relational database used for device management. Such an approach enables fast acquisition of data about infrastructure’s properties and allows merging information about the structure of the managed infrastructure with information devices’ properties and statistics. We develop a graph generator that generates virtual network basing on representative examples of linear infrastructure, incorporation of a data from existing metering systems with the generated structure, which automates the deployment and allows to evaluate the performance of Smart City monitoring and management system. We present results of performance tests that show and the creation time of graph database structures in Neo4j and the difference between the performance of the Microsoft SQL Server database and the Neo4j database in a few Smart City use cases. The results show that the use of the graph database to execute queries related to linear infrastructure allows decreasing the response time up to 9 times.
Hydraulic Reconstruction of the 1818 Giétro Glacial Lake Outburst Flood
Authors: Ancey C. , Bardou E. , Funk M. , Huss M. , Werder M. A. , Trewhela T. 
Published: October 2019

AbstractIn the spring of 1818, ice avalanches from the Giétro Glacier created an ice dam, which in turn formed a glacial lake in the Drance Valley (Canton of Valais, Switzerland). Today, its maximum volume is estimated to have been 25×106 m3. Cantonal authorities commissioned an engineer named Ignaz Venetz to mitigate the risk of the ice dam's failure. He supervised the construction of a tunnel through which a large volume of water was drained as the lake rose (9×106 m3 according to his estimates and 11×106 m3 according to our model). After 2.5 days of slow drainage, the ice dam failed on 16 June 1818 and caused major flooding in the Drance Valley up to 40 km downstream, resulting in about 40 deaths. Venetz's lake monitoring notes, numerous testimonies gathered in the disaster's aftermath, and our field survey have made it possible to collect a wealth of information on this event, which is one of the world's major documented glacial lake outburst floods. Reconstructing major outburst floods remains challenging because not only do they involve enormous volumes of water spreading over long distances but they are also associated with additional physical processes such as massive erosion; intense transport of ice, sediment, and debris; and damage to vegetation and buildings. This paper attempts to reconstruct the 1818 Giétro flood by focusing on its water component. We develop a simple model to estimate the initial hydrograph during the slow drainage and failure phases. The flood's features are deduced by solving the shallow‐water equations numerically. The computational framework involves six free parameters, of which five are constrained by physical considerations. Using iterative manual parameter adjustments, we matched the numerical simulations to the historical data. We found that the peak discharge was close to 14,500 m3/s, the flood's front velocity was about 6 m/s, and flow depth varied considerably along the River Drance's bed (from 30 m just downstream of the ice dam to 2 m on the alluvial fan, 24 km west of the dam). To achieve a good agreement between computations and historical data, we had to select a high value for the Manning friction coefficient n (with n as large as 0.08 s/m1/3). As the Drance Valley is narrow, high flow resistance caused the flood's leading edge to behave like a plug, moving at a fairly constant velocity, with little dependence on what happened behind it. This result may explain why a simple flood routing model is able to reproduce the flood's features, because in an Alpine valley, a lateral spreading of the water volume is limited.
Delayed Umbilical Cord Clamping is Not Associated with Acute Kidney Injury in Very Low Birth Weight Neonates
Authors: Harer Matthew W. , McAdams Ryan M. , Conaway Mark , Vergales Brooke D. , Hyatt Dylan M. , Charlton Jennifer R. 
Published: October 2019

Abstract
Objective This study aimed to determine if delayed cord clamping (DCC) is associated with a reduction in neonatal acute kidney injury (AKI).
Study Design A retrospective single-center cohort study of 278 very low birth weight (VLBW) neonates was performed to compare the incidence of AKI in the following groups: immediate cord clamping (ICC), DCC, and umbilical cord milking. AKI was diagnosed by the modified neonatal Kidney Diseases and Improving Global Outcomes (KDIGO) definition.
Results The incidence of AKI in the first week was 20.1% with no difference between groups (p = 0.78). After adjustment for potential confounders, the odds of developing AKI, following DCC, compared with ICC was 0.93 (confidence interval [CI]: 0.46–1.86) with no reduction in the stage of AKI between groups.
Conclusion In this study, DCC was not associated with a reduced rate of AKI in VLBW neonates. However, the data suggest that DCC is also not harmful to the kidneys, further supporting the safety of DCC in VLBW neonates.
Diversity and trends in population structure of ESBL-producing Enterobacteriaceae in febrile urinary tract infections in children in France from 2014 to 2017
Authors: Birgy André , Madhi Fouad , Jung Camille , Levy Corinne , Cointe Aurélie , Bidet Philippe , Hobson Claire Amaris , Bechet Stéphane , Sobral Elsa , Vuthien Hoang , Ferroni Agnès , Aberrane Saïd , Cuzon Gaëlle , Beraud Laetitia , Gajdos Vincent , Launay Elise , Pinquier Didier , Haas Hervé , Desmarest Marie , Dommergues Marie-Aliette , Cohen Robert , Bonacorsi Stéphane ,   Group of the National Observatory of Urinary tract Infection due to ESBL-producing Enterobacteriaceae in children, Adam Marie-Noëlle , Amara Marlène , Andriantahina Isabelle , Belgaid Abdelmalek , Biscardi Sandra , Boyer Sophie , Branger Catherine , Breant Isabelle , Breuil Jack , Caillon Jocelyne , Cixous Emmanuel , Cojocaru Bogdan , Craiu Irina , Decobert Marion , Dessein Rodrigue , Doucet-Populaire Florence , Dubos François , Ducrocq Sarah , Farges-Berth Anne , Farrugia Cécile , Fiacre Alain , Galerne Aurélien , Garrec Hélène , Georget Emilie , Grimpel Emmanuel , Hees Laure , Labbee Franck , Pitsch Aurélia , Poilane Isabelle , Sivadon-Tardy Valérie , Soussan-Banini Valérie , Starck Benoit , Timsit Sandra , Traore Philippe , Vachee Anne , Vignaud Olivier 
Published: October 2019

Abstract

Background
The population structure of extraintestinal pathogenic Escherichia coli evolves over time, notably due to the emergence of antibiotic-resistant clones such as ESBL-producing Enterobacteriaceae (ESBL-E).

Objectives
To analyse by WGS the genetic diversity of a large number of ESBL-E isolated from urinary tract infections in children from paediatric centres across France between 2014 and 2017 and collected by the National Observatory of febrile urinary tract infection (FUTI) caused by ESBL-E.

Methods
A total of 40 905 Enterobacteriaceae-positive urine cultures were identified. ESBL-E were found in 1983 samples (4.85%). WGS was performed on 251 ESBL-E causing FUTI. STs, core genome MLST (cgMLST), serotype, fimH allele, ESBL genes and presence of papGII key virulence factor were determined.

Results
E. coli and Klebsiella pneumoniae were found in 86.9% (218/251) and 11.2% (28/251) of cases, respectively. Several STs predominate among E. coli such as ST131, ST38, ST69, ST73, ST95, ST405, ST12 and ST1193, while no ST emerged in K. pneumoniae. E. coli ST131, ST38 and ST1193 increased during the study period, with a heterogeneity in papGII prevalence (64.5%, 35% and 20% respectively). Most isolates harboured the CTX-M type (97%) with a predominance of blaCTX-M-15. blaCTX-M-27, an emerging variant in E. coli, is found in various STs. cgMLST enabled discrimination of clusters within the main STs.

Conclusions
The predominance of ST131, and the emergence of other STs such as ST38 and ST1193 combined with ESBL genes deserves close epidemiological surveillance considering their high threat in infectious disease. cgMLST could be a discriminant complementary tool for the analyses.
Importance of Preovipositional Period of an Oligophagous Moth in Predicting Host Suitability
Authors: Kong Weina , Wang Yi , Guo Yongfu , Chai Xiaohan , Li Jie , Ma Ruiyan 
Published: October 2019

AbstractFor oligophagous insects, larval performance is very important to evaluate host suitability in host use. However, key indices among all performance traits including survival, development, and fecundity of the adult insect to predict host suitability are not clear. To investigate the key performance indices, we observed the performance of an oligophagous moth Grapholita molesta (Busck) (Lepidoptera: Tortricidae), a pest mainly damaging rosaceous plants, on three apple varieties, three peach varieties, and three pear varieties in the laboratory by placing its eggs on fruits. The moth’s fitness was evaluated by the intrinsic rate of increase at fruit variety- and species-level variability. Our results showed that the preovipositional period of female moths and longevity of male moths were the indices primarily predicting intrinsic rates of increase for fruit variety and for fruit species. However, the preovipositional period of female moths was different at species-level variability but not at variety-level variability, whereas the longevity of male moths was not different at variety- or species-level variability. These results revealed that preovipositional period of female moths was a key predictor for host suitability in G. molesta. This study highlighted that gravid females may be a principal indicator in host resource optimization for oligophagous insects.
Samples From Cases of Delusional Parasitosis as Seen in the UK Parasitology Reference Laboratory (2014–2015)
Authors: Garcia-Mingo A , Dawood N , Watson J , Chiodini P L 
Published: October 2019

Abstract
Delusional parasitosis is a common syndrome seen in Infectious Diseases clinics. These patients characteristically provide samples as evidence of their infestation. We prospectively catalogued and characterized 138 samples from these patients, processed in the UK Clinical Parasitology reference laboratory from January 2014 to April 2015. No human parasites were identified.