bluuebunny/crossref_metadata_2025_split huggingface dataset:
Production and characterisation of duck albumen hydrolysate using enzymatic process
Authors: Quan Tran Hong , Benjakul Soottawat 
Published: May 2019

SummaryInfluences of different ultrasound treatments combined with heat pretreatment on enzymatic hydrolysis, emulsifying properties and antioxidant activities of hydrolysates from duck egg albumen were studied. Heat pretreatment at 95 °C for 30 min inhibited both serine and cysteine protease inhibitors effectively. Ultrasonication of heated duck albumen at 60% amplitude for 10 min yielded the highest surface hydrophobicity. Coincidentally, aforementioned pretreatment rendered the hydrolysate with highest degree of hydrolysis (DH) than other pretreatments when Alcalase was used. The resulting hydrolysate showed the highest antioxidant activities including DPPH radical and ABTS radical cation scavenging activities and ferric reducing antioxidant power as well as emulsifying properties when hydrolysis time of 90 min was used. The hydrolysate possessed the peptides with molecular weight of 219–255 Da with the highest ABTS radical scavenging activity. Thus, heat pretreatment, followed by ultrasonication of duck albumen under appropriate condition could increase DH, antioxidant activities and emulsifying properties of duck albumen hydrolysate.
Phenotyping of interstitial cystitis/bladder pain syndrome
Authors: Akiyama Yoshiyuki , Hanno Philip 
Published: May 2019

AbstractInterstitial cystitis/bladder pain syndrome is a chronic, potentially debilitating condition characterized by pain perceived to be related to the bladder in conjunction with lower urinary tract symptoms, and includes a wide variety of clinical phenotypes with diverse etiologies. Currently the only clinically relevant proven phenotype of interstitial cystitis/bladder pain syndrome is the Hunner lesion. Whether the presence of Hunner lesions is a hallmark of a distinct disease cohort or a potentially transient feature of non‐Hunner lesion phenotype has been debated but remains controversial. There are few documented examples of a patient converting between the two forms. Growing clinical and basic evidence supports eliminating the Hunner lesion phenotype from the bladder pain syndrome umbrella and considering it a distinct disease. The Hunner lesion phenotype is characterized by distinct bladder histology, including subepithelial chronic inflammatory changes and epithelial denudation, and specific clinical characteristics (older onset age, severe bladder‐centric symptoms, reduced bladder capacity, and favorable response to the lesion‐targeted therapies). To define the Hunner lesion phenotype, it is necessary to develop an atlas of standardized images of cystoscopic (and, if possible, pathological) appearances of Hunner lesions. A true potential and clinically relevant phenotype of interstitial cystitis/bladder pain syndrome may be patients with non‐bladder‐centric symptoms, characterized by the affect dysregulation and somatic symptoms, and a greater bladder capacity in absence of Hunner lesions. In the present workshop, we concluded that the Hunner lesion is a valid phenotype and can reasonably be considered a disease in its own right. Assessment of bladder capacity and the extent of symptoms (bladder beyond or bladder centric) may help phenotyping of interstitial cystitis/bladder pain syndrome. Proper phenotyping is essential for the diagnosis and treatment of interstitial cystitis/bladder pain syndrome, and for facilitating research.
Validity of the Brazilian version of the Dental Subscale of Children's Fear Survey Schedule
Authors: Cademartori Mariana Gonzalez , Cara Gleidi , Pinto Gabriela dos Santos , da Costa Vanessa Polina Pereira 
Published: May 2019

AbstractBackgroundDental Subscale of Children's Fear Survey Schedule (CFSS‐DS) is a tool widely used to assess dental fear in children.AimTo translate and to verify the psychometric properties, including factor analyses of the Brazilian version of the CFSS‐DS (B‐CFSS‐DS) in two settings.DesignThe CFFS‐DS was translated into the Portuguese language. In the first cross‐sectional study (dental setting), 128 children (age: 4‐12 years) participated. Mothers were interviewed; children's dental fear was assessed through the CFSS‐DS and the Venham picture test; and child behaviour was assessed using the Frankl Scale. The second was a longitudinal study, with 103 schoolchildren (age: 4‐12 years). Two receiver operating characteristic curves were drawn to establish the cut‐off points.ResultsThe B‐CFSS‐DS version showed good internal consistency in dental and school settings (Cronbach's α = 0.88 and 0.77 respectively) and a good test‐retest reliability (Weighted Kappa = 0.767), as well as good criterion and discriminant validities. Factor analyses showed four factors.ConclusionThe Brazilian version of the CFSS‐DS is a valid tool for dental fear assessment in children aged 4‐12 years. Further studies with representative samples should be performed to strengthen the findings of this study, especially in the school setting.
Dopamine receptor D2 and ankyrin repeat domain containing one in temporomandibular disorder of adolescents
Authors: Franco Gizele Batista , Faturri Aluhe Lopes , Meger Michelle Nascimento , de Paiva Bertoli Fernanda Mara , Wambier Letícia Maira , Scariot Rafaela , de Souza Juliana Feltrin , Küchler Erika Calvano , Brancher João Armando 
Published: May 2019

AbstractBackgroundTemporomandibular disorder (TMD) is a multifactorial condition that combines environmental and genetic factors and its prevalence increases during adolescence.AimTo investigate the association between TMD and genetic polymorphisms in the DRD2 and ANKK1 in a population of Brazilian adolescents.DesignThe TMD group included adolescents diagnosed with any of the following TMD subgroups according to the RDC/TMD criteria: myofascial pain, arthralgia and disc displacement and painful TMD. Genomic DNA for molecular analysis was extracted from buccal cells, and genetic polymorphism rs6275 in DRD2 and rs1800497 in ANKK1 were genotyped by real‐time polymerase chain reactions using the TaqMan assay. Data were analysed using the Epi Info 3.5.7 and Stata software, with significance level of 0.05.ResultsTwo hundred fifty‐one individuals were included in this study, 148 subjects presented TMD. For disc displacement, the genetic polymorphisms rs6275 was associated in a recessive model (P = 0.04), whereas the rs6276 and rs1800497 presented only a borderline association in a recessive and dominant models, respectively (P = 0.07 and P = 0.06).ConclusionThe genetic polymorphism rs6275 in DRD2 was associated with disc displacement in Brazilian adolescents.
Large neighborhood search for the bike request scheduling problem
Authors: Vergeylen Nicholas , Sörensen Kenneth , Vansteenwegen Pieter 
Published: May 2019

AbstractThis paper introduces an efficient algorithm for the bike request scheduling problem (BRSP). The BRSP is built around the concept of request, defined as the pickup or dropoff of a number of identical items (bikes) at a specific station, within a certain time window, and with a certain priority. The aim of the BRSP is to sequence requests on (and hence determine the routes of) a set of vehicles, in such a way that the sum of the priorities of the executed requests is maximized, all time windows are respected, and the capacity of the vehicles is not exceeded. The generation of the set of requests is explicitly not a part of the problem definition of the BRSP. The primary application of the BRSP, from which it derives its name, is to determine the routes of a set of repositioning vehicles in a bike sharing system, although other applications exist. The algorithm introduced in this paper is based on a set of related greedy randomized adaptive search procedure followed by variable neighborhood descent (GRASP + VND) operators embedded in a large neighborhood search (LNS) framework. Since this paper presents the first heuristic for the BRSP, a computational comparison to existing approaches is not possible. We therefore compare the solutions found by our LNS heuristic to those found by an exact solver (Gurobi). These experiments confirm that the proposed algorithm scales to realistic dimensions and is able to find near‐optimal solutions in seconds.
Helping hospitalized smokers in Hong Kong quit smoking by understanding their risk perception, behaviour, and attitudes related to smoking
Authors: Li William Ho Cheung , Ho K. Y. , Xia Viveka W. , Wang M. P. , Lam Katherine K. W. , Chan Sophia S. C. , Lam T. H. 
Published: May 2019

AbstractAimTo understand the risk perceptions, behaviour, attitudes, and experiences related to smoking among hospitalized Chinese smokers.BackgroundUnderstanding hospitalized smokers’ perceptions of risks associated with smoking, along with their behaviour, attitudes, and smoking‐related experiences, is essential prerequisite to design effective interventions to help them quit smoking.DesignA phenomenological research design was adopted.MethodsA purposive sampling approach was used. Between May 2016‐January 2017, 30 hospitalized smokers were invited for an interview.ResultsFour themes were generated: (a) associations between perception of illness and smoking; (b) perceived support from healthcare professionals to quit smoking; (c) impact of hospitalization on behaviour, attitudes, and experiences; and (d) perceived barriers to quitting smoking.ConclusionDevelopment of an innovative intervention that helps to demystify misconceptions about smoking through brief interventions and active referrals is recommended to enhance the effectiveness of healthcare professionals promoting smoking cessation for hospitalized smokers.ImpactTo date, no study examining smoking behaviour among hospitalized patients in Hong Kong has been conducted. Misconceptions about smoking and health, barriers to quitting that outweighed perceived benefits, lack of support from healthcare professionals, and difficulty overcoming withdrawal symptoms or cigarette cravings precluded hospitalized smokers sustaining smoking abstinence after discharge. Smoking is detrimental to physical health. Smoking cessation has beneficial effects on treatment efficacy and prognosis and helps to reduce the economic burden on society from smoking‐attributable diseases.
Loss of retinal ganglion cells in a new genetic mouse model for primary open‐angle glaucoma
Authors: Reinehr Sabrina , Koch Dennis , Weiss Maximilian , Froemel Franziska , Voss Christina , Dick H. Burkhard , Fuchshofer Rudolf , Joachim Stephanie C. 
Published: May 2019

AbstractPrimary open‐angle glaucoma (POAG) is one of the most common causes for blindness worldwide. Although an elevated intraocular pressure (IOP) is the main risk factor, the exact pathology remained indistinguishable. Therefore, it is necessary to have appropriate models to investigate these mechanisms. Here, we analysed a transgenic glaucoma mouse model (βB1‐CTGF) to elucidate new possible mechanisms of the disease. Therefore, IOP was measured in βB1‐CTGF and wildtype mice at 5, 10 and 15 weeks of age. At 5 and 10 weeks, the IOP in both groups were comparable (P > 0.05). After 15 weeks, a significant elevated IOP was measured in βB1‐CTGF mice (P < 0.001). At 15 weeks, electroretinogram measurements were performed and both the a‐ and b‐wave amplitudes were significantly decreased in βB1‐CTGF retinae (both P < 0.01). Significantly fewer Brn‐3a+ retinal ganglion cells (RGCs) were observed in the βB1‐CTGF group on flatmounts (P = 0.02), cross‐sections (P < 0.001) and also via quantitative real‐time PCR (P = 0.02). Additionally, significantly more cleaved caspase 3+ RGCs were seen in the βB1‐CTGF group (P = 0.002). Furthermore, a decrease in recoverin+ cells was observable in the βB1‐CTGF animals (P = 0.004). Accordingly, a significant down‐regulation of Recoverin mRNA levels were noted (P < 0.001). Gfap expression, on the other hand, was higher in βB1‐CTGF retinae (P = 0.023). Additionally, more glutamine synthetase signal was noted (P = 0.04). Although no alterations were observed regarding photoreceptors via immunohistology, a significant decrease of Rhodopsin (P = 0.003) and Opsin mRNA (P = 0.03) was noted. We therefore assume that the βB1‐CTGF mouse could serve as an excellent model for better understanding the pathomechanisms in POAG.
Oral iron‐based interventions for prevention of critical outcomes in pregnancy and postnatal care: An overview and update of systematic reviews
Authors: Abraha Iosief , Bonacini Maria Isabella , Montedori Alessandro , Di Renzo Gian Carlo , Angelozzi Patrizio , Micheli Marta , Germani Antonella , Carloni Danilo , Scaccetti Augusto , Palmieri Gianluca , Casali Marta , Nenz Chiara Maria Grazia , Gargano Elisabetta , Pazzaglia Michela , Agea Elisabetta , Berchicci Laura , Tesoro Simonetta , Albi Nicola , Minelli Olivia , Pasqua Barbara Luciani , Onorato Marina , Epicoco Giorgio , Marchesi Mauro 
Published: May 2019

AbstractObjectiveThe aim of this work was to summarize and update the evidence concerning oral iron‐based interventions compared to placebo or no iron‐based interventions to prevent critical outcomes in pregnancy or treat critical outcomes in the postpartum phase.MethodPublished systematic reviews (Feb 2018) and primary studies (from 2015 to March 2018) retrieved from MEDLINE, EMBASE, and the Cochrane Library were examined. The AMSTAR (Assessing the Methodological Quality of Systematic Reviews) tool was used to assess the quality of reviews. GRADE was used to rate the quality of the evidence for critical outcomes.ResultsAntenatal care: Compared to placebo/no treatment, iron‐based therapies reduced maternal anemia at term by 59% (seven trials at low risk of bias, RR 0.41, 95% CI 0.23‐0.73; I2 = 86%; moderate‐quality evidence) and maternal iron deficiency anemia by 67% (RR 0.33, 95% CI 0.16‐0.69; I2 = 49%). There was no evidence of difference between iron‐based therapies vs control in terms of side effects (RR 1.42, 95% CI 0.91‐2.21), preterm delivery (13 studies: RR 0.93, 95% CI 0.84‐1.03; low‐quality evidence), low birthweight (RR 0.94, 95% CI 0.79‐1.13; low‐quality evidence) and infant mortality (RR 0.93, 0.72‐1.20; low‐quality evidence).Postnatal careThere was insufficient evidence to determine whether iron‐based therapies can reduce postpartum anemia.ConclusionIron supplementation is effective in preventing maternal anemia at term but not low birthweight, preterm delivery or infant mortality.
A Chinese practice guideline of the assisted reproductive technology strategies for women with advanced age
Authors: Jiang Li , Chen Yaolong , Wang Qi , Wang Xiaoqin , Luo Xufei , Chen Junqiao , Han Hongjing , Sun Yingpu , Shen Huan ,   Chinese Society of Reproductive Medicine (CSRM)
Published: May 2019

AbstractMore women postpone childbearing nowadays while female fertility begins to decline with advancing age. Furthermore, with the rolling out of the two‐child policy, there is a huge demand for a second child for Chinese aged women. There are various assisted reproductive technology (ART) strategies applied for age‐related infertility without solid evidence. On behalf of the Society of Reproductive Medicine, Chinese Medical Association, we would like to develop a Chinese guideline of ART strategies for age‐related infertility. This guideline was produced following the recommendations for standard guidelines described in the 2012 WHO Handbook for guideline development. The Grading of Recommendations Assessment, Development, and Evaluation (GRADE) framework was also followed. A protocol was formulated and a Guideline Development Group was formed with specialists of reproductive medicine, methodologists from Chinese GRADE working group, and patient representative. Questions regarding the ART strategies for aged infertility were formulated and 8 most important ones were chosen to be structured in PICO format (Population, Intervention, Comparison, Outcomes). Comprehensive search and review of the literature were performed and the quality of the evidence was assessed and rated based on certain criteria and be categorized as high, moderate, low, or very low. Twenty‐five recommendations were formulated among members of the Guidelines Development Group (Delphi method) basing on the overall quality of the evidence, in addition to the balance between benefits and harms, values and preferences, and resource implications. The final recommendations were agreed on by consensus during face‐to‐face meetings. This is the first Chinese practice guideline in reproductive medicine developed following the standard and scientific method.
Beyond uncertainty: Negative findings for the association between the use of proton pump inhibitors and risk of dementia
Authors: Park Sun‐Kyeong , Nam Jin Hyun , Lee Hyesung , Chung Hyunsoo , Lee Eui‐Kyung , Shin Ju‐Young 
Published: May 2019

AbstractObjectivesWe investigated the risk of dementia associated with the use of proton pump inhibitors (PPIs) as compared with the use of histamine‐2 receptor antagonist (H2RA).MethodsWe conducted retrospective propensity score‐matched cohort study using the National Health Insurance Service‐National Sample Cohort. Subjects were defined as the patients newly prescribed with PPI or H2RA between 2003 and 2013 without prior prescriptions of PPI/H2RA or diagnosis of dementia from their history within the past 1 year. We followed up participants until dementia occurrence, death, or the end of the study, whichever occurred first, with an intention‐to‐treat approach. A 1‐year lag time between exposure and outcome measure was used to reduce protopathic bias. The incidence rate per 1000 person‐years was estimated. The incidence rate of PPI was compared with that of H2RA, defined as incidence rate ratio (IRR), calculated with a 95% confidence interval. To control for potential confounds, propensity score matching at a 1:1 ratio was conducted, and the crude IRR was adjusted by risk factors.ResultsOur propensity score‐matched cohort included 87 562 patients on PPIs and 87 562 patients on H2RAs. The IRR was 1.01 (95% confidence interval 0.96–1.06) with 1‐year lag time. IRR showed the decreased trend as the longer lag time. Also, no treatment duration or dose–response relationship was observed.ConclusionsOur finding demonstrated that PPIs did not associate with dementia more strongly than did H2RA. On this basis, we suggest that the previously reported risk for dementia associated with PPI may have been overestimated.
Effects of aromatherapy massage on pain, functional state, and quality of life in an elderly individual with knee osteoarthritis
Authors: Pehlivan Seda , Karadakovan Ayfer 
Published: May 2019

AbstractAimTo investigate the effects of aromatherapy massage on pain, functional state and life quality of elderly individuals with knee osteoarthritis.MethodsThis controlled and experimental study was conducted in two nursing homes. In this study, 90 elderly individuals with knee osteoarthritis were randomized as aromatherapy, massage and control groups. Data were collected in weeks 0, 4, and 8 using Patient Information Form, Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) Knee Osteoarthritis Evaluation Scale, OsteoArthritis Knee and Hip Quality of Life Scale (OAKHQoL). Aromatherapy and massage groups received a total of 15–20 min total classic leg massage twice weekly for 3 weeks. In the aromatherapy group, two essential oils (ginger and rosemary) were added to the black seed oil.ResultsIn the aromatherapy group, WOMAC (pain and functional state) scores were lower and quality of life scores were higher than the massage and control groups in week 4, and these differences were statistically significant (p < .001). These significant differences were present in the massage group when compared with the control (p < .001). These significant differences in the aromatherapy group were also sustained decreasingly in week 8 (p < .001), while the means were not different from baseline in the massage group (p > .05).ConclusionsAromatherapy massage performed in elderly patients with knee osteoarthritis reduced pain and improved functional status and quality of life. The week 8 findings showed that aromatherapy has more favorable and longer sustained effects than the massage.
Adaptive velocity‐dependent proportional‐integral controller for high‐speed atomic force microscopy
Authors: LIU L. , WU S. , WANG Y.Y. , HU X.D. , HU X.T. 
Published: May 2019

SummaryHigh‐speed atomic force microscopy (AFM) has been rapidly developed in recent years. To reduce the oscillation of the scanner, a single‐tone sinusoidal wave is widely used as a scanning wave rather than a triangular wave in high‐speed AFM. However, the sinusoidal wave is nonlinear, resulting in a nonconstant relative linear velocity between the sample and the tip while scanning in the x‐direction. If a traditional proportional‐integral controller is still used as a feedback controller in the z‐direction, the control errors will be enormous. Therefore, the paper proposes a new adaptive velocity‐dependent proportional‐integral controller. The relationship between the proportional‐integral parameters and the linear velocity is achieved by fitting the experimental results. The adaptive and traditional controllers are compared against each other in some examples. The experiments demonstrate that the adaptive controller decreases the control errors in the z‐direction to a half, which provides more precise AFM images.Lay DescriptionTypically, the scanner follows a triangular waveform in fast axis (x‐axis), and follows a very slow ramp signal in the slow axis (y‐axis) of conventional AFM. This scanning mode can be called raster scan. However, the triangular waveform contains high‐order Fourier harmonics, vibrating the scanner and distorting the image easily. In high‐speed AFM, the effect of the high‐order Fourier harmonics will be more severe. The above problems can be solved by replacing triangular waves with single‐tone sinusoidal waveform. Therefore, the sinusoidal‐raster scan and nonraster scan based on the sinusoidal waveform are widely used in high‐speed atomic force microscopy.However, the nonlinearly scan path will cause a variable relative linear velocity between the sample and the tip. If a standard proportional‐integral controller is still used as a feedback controller in Z direction, the control errors will be large, and this difference will be evident at high‐speed scanning. Thus, the paper proposes a new adaptive velocity‐dependent proportional‐integral controller to solve this problem. Experiments show that the control errors obtained by using the adaptive controller is about a half of that without using it. These illustrate that the proposed method can improve the image quality of the AFM at both low and high scan speeds.