bluuebunny/crossref_metadata_2025_split huggingface dataset:
A framework for developing generic implant safety procedures for scanning patients with medical implants and devices in MRI
Authors: Ashmore Jonathan P , Prescott Sarah J , McLean John , Wilson Daniel J , Charles-Edwards Geoff , Wright Peter , Grainger David , Barker Gareth J , Lipton Alexandra J , Watt Rachel , Gopalan Deepa , Radon Mark R 
Published: November 2024

Abstract
UK guidelines for MR safety recommend that MRI departments refer to the implant manufacturer for advice regarding the MRI safety of scanning patients with an implantable medical device prior to scanning. This process of assuring safety can be time consuming, leading to delays and potential cancellations of a patient’s MRI. Furthermore, at times the implant cannot be identified, or the implant manufacturers cannot provide up to date MRI safety information. The purpose of generic implant safety procedures is to define a process for managing patients with certain types of implants where the risk from scanning is low. This process incorporates scope for an evidence-based risk-benefit decision to scan some groups of patients under locally approved conditions, without seeking to identify the exact make and model of the implant and subsequent assurance of MR safety from the implant manufacturer. This publication provides best practice recommendations from a multi-professional working group for the development of these procedures. It is supported by The Institute of Physics and Engineering in Medicine, The Society of Radiographers, The Royal College of Radiologists, The British Institute of Radiology, The British Association of MR Radiographers, The International Society of Magnetic Resonance in Medicine British and Irish Chapter, and the NHS Scotland MRI Physics Group.
OGC SO30 - Radiological thoracic duct embolisation for post oesophagectomy chyle leak: A single centre retrospective review
Authors: Fernandes Shriya , Snook Rhea , Kynes Larissa , McDonnell Declan , Maher Ben , Noble Fergus , Byrne James , Underwood Tim , Kelly Jamie , White Michael 
Published: November 2024

Abstract

Background
Chyle leak is a recognised complication of oesophagectomy associated with increased length of hospital stay, morbidity and is potentially fatal. Chyle leak management is controversial, and lacks a standardised or validated approach. Interventional radiological approaches are well described and routinely able to identify and embolise these thoracic duct leaks reducing need for return to theatre. The aim is to retrospectively evaluate outcomes of lymphangio-embolisation and in patients post Ivor Lewis oesophagectomy for oesophageal carcinoma.

Method
Data was analysed retrospectively from 168 patients who underwent Ivor Lewis oesophagectomy for oesophageal carcinoma from June 2020 to June 2024, of which 15 patients had chyle leak post operatively. Chyle leak was suspected when chest drain output &gt;500ml in 24 hours and confirmed by high biochemical levels of chylomicrons and triglycerides within the drain fluid. Conservative management involved keeping the patient nil by mouth, total parenteral nutrition and monitoring intercostal drain output. Thoracic duct lymphangiogram was carried out to confirm location of chyle leak-embolisation was carried out using the femoral approach with lipidiol and/or microcoils and/or glue.

Results
15 out of 168 (9%) patients had post operative chyle leaks. Four resolved with conservative management within &lt;14 days. 11 chyle leaks persisted after a median of 17 days (range 14-30 days) conservative management and went onto have thoracic duct embolisation. Of those embolised, six chyle leaks resolved within three days post procedure. Two resolved 5-7 days post embolization. One had repeat embolization seven days post primary embolisation. Two patients required thoracoscopic ligation of thoracic duct, due to obesity making embolisation technically impossible and lack of interventional radiology capacity respectively. No patients had adverse outcomes.

Conclusion
Thoracic duct embolisation is an effective and safe approach for routine management of post oesophagectomy chyle leaks and may reduce return to theatre.
HPB SO37 - GTN Patch for Medical Relaxation of the Sphincter of Oddi: “A Safe and Effective Pre-ERCP Treatment for Controlled Bile Leak Post-Cholecystectomy"
Authors: Zino Samer , Thiagarajah Sai Viswan Karthigesu , Bakewell Zoe , Bright Euan 
Published: November 2024

Abstract

Background
Bile leak is a frequent complication following laparoscopic total, subtotal cholecystectomy, and bile duct exploration (BDE) with an incidence up to 2.8%. It can contributing significantly to postoperative morbidity and mortality. GTN has demonstrated efficacy in reducing papillary muscle contraction and Sphincter of Oddi pressure. Similarly GTN might promote healing and closure of bile leaks post total or subtotal cholecystectomy. This study aims to assess the safety and effectiveness of GTN in treating bile leaks post total, subtotal cholecystectomy or bile duct exploration.

Method
Data was prospectively collected from patients who developed bile leaks after total or subtotal cholecystectomy between June 2020 and June 2024. Inclusion criteria were patients with a bile leak post-surgery during this period. Exclusion criteria included unstable patients, uncontrolled bile leaks, the presence of biliary obstruction, or major bile duct injuries. Suitable patients were treated with a GTN patch as first line management before potential ERCP. A 5 mg GTN skin patch was applied every 24 hours, starting at least 48 hours post-surgery if drain output exceeded 100 ml/hour. Patients were consented about side effects including hypotension and headache.

Results
Seven patients were treated with GTN, with mean age of 51 years, four were females. Four cases were emergencies and four had subtotal cholecystectomies, one in the elective group. Bile leaks occurred after biloma drainage and one after removal of trans-cystic drain post trans-cystic BDE. All patients experienced significant drain output reduction the day after starting GTN. There were no complications during or after treatment. One required ERCP two months later for persistent low-volume bile leak of 5-10 ml per day. Headaches occurred in two cases, treatment was discontinued in one. The average time to GTN treatment was 3.4 days.

Conclusion
This study demonstrates GTN treatment's safety and effectiveness for managing bile leaks following total, subtotal cholecystectomy or BDE. We recommend GTN as the primary therapy for controlled bile leaks, barring biliary obstruction or major injury. Response can be evaluated within 24-48 hours through significant output reduction. Implementing local protocols can minimize variations in GTN treatment initiation times. GTN should be prioritized over ERCP to prevent complications like perforation, pancreatitis, and bleeding. We aim for this study to underscore GTN's efficacy to surgeons and promote multicentre research initiatives.
Factors associated with self-initiated moves during the formal eviction process
Authors: Nilsson Ida 
Published: November 2024

Abstract
Housing eviction is a common occurrence, affecting hundreds of thousands of Europeans annually. It is well known that it primarily impacts the most vulnerable groups in society and is associated with adverse outcomes. However, previous research heavily relies on enforced removals registered in official statistics, thus missing eviction outcomes that do not undergo or disrupt the formal eviction process. This exploratory study, based on unique national Swedish register data on evictions with a sample of over 60,000 individuals, examines self-initiated moves and contrasts them with enforced removals and lease regain. Results from univariable and multivariable multinomial logistic regression analyses indicate that economic hardship and living in a single household are associated with both self-initiated moves and enforced removals. However, distinct factors associated with self-initiated moves are aged under twenty-five, living as a couple with children, residing in a non-metropolitan municipality, and having a native background. Gender-stratified analysis highlights strong associations for young women and native-background women with self-initiated moves. The results underscore the significance of implementing preventive social services interventions that address the specific needs of this larger group of individuals who face evictions under a broader definition. Further implications for research, policy, and social work practice are discussed.
Concussion leads to opposing sensorimotor effects of habituation deficit and fatigue in zebrafish larvae
Authors: Köcher Laura , Beppi Carolina , Penner Marco , Meyer Samuel , Bögli Stefan Yu , Straumann Dominik 
Published: November 2024

Abstract
Concussion, or mild traumatic brain injury, is caused by sudden mechanical forces impacting the brain either directly or through inertial loading. This can lead to physical, behavioural and cognitive impairments. Despite concussion being a significant health issue, our understanding of the relationship between initial impact force and the subsequent neurological consequences is not well understood. Previously, we established a model of concussion in zebrafish larvae. Here, we further investigate concussions of varying severities in zebrafish larvae using linear deceleration. Using an acoustic assay to monitor the larval sensorimotor behaviour, we found that different parameters of the resulting escape behaviour are modulated by the impact force of the preceding concussive insult. To investigate the relative contributions of habituation performance and fatigue on the escape response behaviour, we constructed a neurocomputational model. Our findings suggest that a concussive impact initially affects habituation performance at first and, as the impact force increases, fatigue is induced. Fatigue then alters the escape response behaviour in an opposing manner.
Motor learning is modulated by dopamine availability in the sensorimotor putamen
Authors: Muehlberg Christoph , Goerg Sophia , Rullmann Michael , Hesse Swen , Sabri Osama , Wawrzyniak Max , Classen Joseph , Fricke Christopher , Rumpf Jost-Julian 
Published: November 2024

Abstract
Successful motor skill acquisition requires the dynamic interaction of multiple brain regions, with the striatum playing a critical role in this network. Animal studies suggest that dopaminergic mechanisms are involved in the regulation of motor learning–associated striatal plasticity. In humans, however, the contribution of nigrostriatal dopaminergic transmission to motor learning remains elusive beyond its well-characterized role in initiation and fluent execution of movements. In this prospective observational study, we investigated motor sequence learning in individuals who had undergone 123I-N-ω-fluoropropyl-2β-carbomethoxy-3β-(4-iodophenyl)nortropane single-photon emission computed tomography for the differential diagnosis of Parkinson's disease (n = 41) and age-matched healthy controls (n = 20). We found that striatal dopamine transporter depletion exhibited distinct spatial patterns that were associated with impairments in motor sequence learning and the manifestation of Parkinsonian motor symptoms, respectively. Specifically, significant associations between striatal dopamine transporter depletion and impairments in motor sequence learning were confined to posterior putaminal regions, whereas significant associations of striatal dopamine transporter depletion with Parkinsonian motor symptom severity showed a widespread spatial pattern across the entire striatal volume with an anterior maximum. Normative functional connectivity analysis revealed that both behavioural domains shared largely overlapping connectivity patterns with the basal ganglia and supplementary motor area. However, apart from connectivity with more posterior parts of the supplementary motor area, significant functional connectivity with primary motor cortical areas was only present for striatal dopamine transporter availability–related modulation of online motor learning. Our findings indicate that striatal dopaminergic signalling plays a specific role in motor sequence learning beyond its influence on mere motor execution, implicating learning-related sensorimotor striatum recruitment and cortico-striatal plasticity as dopamine-dependent mechanisms.
Patient-reported outcome measures for life participation in patients with chronic kidney disease: a systematic review
Authors: Hughes Anastasia , Ju Angela , Cazzolli Rosanna , Howell Martin , Caskey Fergus J , Elliott Meghan J , Farragher Janine , Greenwood Sharlene , Levin Adeera , Manera Karine , Sluiter Amanda , Teixeira-Pinto Armando , Trimarchi Hernán , Wang Bill , Guha Chandana , Wu Rebecca , Jauré Allison 
Published: November 2024

ABSTRACT

Background
The symptoms, comorbidities and treatment burden associated with chronic kidney disease (CKD) can be debilitating and limit life participation in patients with CKD not requiring kidney replacement therapy (KRT). The aim of this study was to identify the characteristics, content and psychometric properties of patient-reported outcome measures (PROMs) used to assess life participation in patients with CKD.

Methods
We searched MEDLINE, Embase, PsycINFO and CINAHL from database inception to February 2023 for all studies that reported life participation in patients with CKD (stages 1–5 not requiring kidney replacement therapy). We analysed the characteristics, dimensions of life participation and psychometric properties of the measures.

Results
From the 114 studies included, 20 (18%) were randomized trials, 3 (3%) were non-randomized trials and 91 (80%) were observational studies. Forty-one different measures were used to assess life participation, of which six (15%) were author-developed measures. Twelve (29%) measures assessed life participation specifically, while 29 (71%) measures assessed broader constructs such as quality of life, which included questions relevant to life participation. The 36-Item Short Form Health Survey (SF-36) and Kidney Disease Quality of Life Short Form (KDQOL-SF) were the most frequently used, in 39 (34%) and 24 (21%) studies, respectively. Many content domains for life participation were assessed, including physical activities (walking, running and sports), social activities, leisure activities, work or study and self-care. None of the measures for life participation were developed specifically for CKD. Four measures (EuroQol 5-dimension 3-level (EQ-5D-3L), Functional Assessment of Cancer Therapy - Anemia, Short Form 6-dimension and Short-From 36-dimension (SF-36)) had validation data collected in patients with CKD.

Conclusion
The measures for life participation used in patients with CKD vary in content, with few validated in the CKD population. There is a need for a validated measure to assess life participation in a meaningful and consistent way in all patients with CKD worldwide.
Liver dysfunction as a rare presentation of ICD lead-induced tricuspid regurgitation: a case report
Authors: Fleming Suzannah , Somarakis Konstantinos , Squire Gareth , Goldney Jonathan , Loke Ian 
Published: November 2024

Abstract

Background
Implanted cardiac devices with right ventricular leads can cause tricuspid regurgitation and subsequent heart failure. In these patients, congestive hepatopathy because of tricuspid regurgitation is well documented; however, the presentation of liver dysfunction without overt heart failure is rare.

Case summary
We report a case of a 56-year-old man with presumed hypertrophic cardiomyopathy, presenting with jaundice without signs of decompensated heart failure, 8 years post-implantation of dual-chamber implantable cardiac defibrillator (ICD). A workup for abnormal liver function, including a liver biopsy, determined congestive hepatopathy as the cause. Cardiac imaging revealed severe tricuspid regurgitation caused by right ventricular ICD lead causing tricuspid valve malposition. Management included both tricuspid valve replacement and extraction of ICD, and there was an excellent recovery.

Discussion
This is a rare case where severe tricuspid regurgitation and congestive hepatopathy secondary to an ICD lead presented with jaundice in the absence of signs of decompensated heart failure. In patients with an implanted cardiac device presenting with signs of liver dysfunction, congestive hepatopathy secondary to tricuspid regurgitation should be considered.
Response of the nephron arterial network and its interactions to acute hypertension: a simulation
Authors: Marsh Donald J , Holstein-Rathlou Niels-Henrik 
Published: November 2024

Abstract
We simulated the dynamics of a group of 10 nephrons supplied from an arterial network and subjected to acute increases in blood pressure. Arterial lengths and topology were based on measurements of a vascular cast. The model builds on a previous version exercised at a single blood pressure with 2 additional features: pressure diuresis and the effect of blood pressure on efferent arteriolar vascular resistance. The new version simulates autoregulation, and reproduces tubule pressure oscillations. Individual nephron dynamics depended on mean arterial pressure and the axial pressure gradient required to cause blood flow through the arteries. Rhythmic blood withdrawal into afferent arterioles caused blood flow fluctuations in downstream vessels. Blood pressure dependent changes in nephron dynamics affected synchronization metrics. The combination of vascular pressure gradients and oscillations created a range of arterial pressures at the origins of the 10 afferent arterioles. Because arterial blood pressure in conscious animals has 1/f dynamics, we applied an arterial pressure pattern with such dynamics to the model. Amplitude of tubule pressure oscillations were affected by the 1/f blood pressure fluctuations, but the oscillation frequencies did not change. The pressure gradients required to deliver blood to all afferent arterioles impose a complexity that affects nephrons according to their locations in the network, but other interactions compensate to ensure the stability of the system. The sensitivity of nephron response to location on the network, and the constancy of the tubular oscillation frequency provide a spatial and time context.
Network hub gene detection using the entire solution path information
Authors: Kuismin Markku , Sillanpää Mikko J 
Published: November 2024

Abstract
Gene co-expression networks typically comprise modules and their associated hub genes, which are regulating numerous downstream interactions within the network. Methods for hub screening, as well as data-driven estimation of hub co-expression networks using graphical models, can serve as useful tools for identifying these hubs. Graphical model-based penalization methods typically have one or multiple regularization terms, each of which encourages some favorable characteristics (e.g. sparsity, hubs, and power-law) to the estimated complex gene network. It is common practice to find a single optimal graphical model corresponding to a specific value of the regularization parameter(s). However, instead of doing this, one could aggregate information across several graphical models, all of which depend on the same data set, along the solution path in the hub gene detection process. We propose a novel method for detecting hub genes that utilizes the information available in the solution path. Our procedure is related to stability selection, but we replace resampling with a simple statistic. This procedure amalgamates information from each node of the data-driven graphical models into a single influence statistic, similar to Cook’s distance. We call this statistic the Mean Degree Squared Distance (MDSD). Our simulation and empirical studies demonstrate that the MDSD statistic maintains a good balance between false positive and true positive hubs. An R package MDSD is publicly available on GitHub under the General Public License https://github.com/markkukuismin/MDSD.
Double-diffusive layering during the evolution of planetary mantles
Authors: Dude Sabine , Hansen Ulrich 
Published: November 2024

SUMMARY
The degree of layering during planetary mantle evolution has been a key issue and is still heavily debated, especially since the observation of seismic discontinuities within the Earth mantle and their correlation to phase transitions within the mantle mineral assemblage and the detection of geochemical differences in mantle derived basalts (Mid Ocean Ridge Basalts and Ocean Island Basalts). We present the phenomenon of double-diffusive layering in a fluid with strongly temperature dependent viscosity, as relevant for planetary mantle material, to study the influence of an initial compositional gradient with regard to the thermal and chemical evolution of a planet. The numerical experiments show that in a wide parameter range distinct layers are formed self-organized from a continuously stratified state by dynamic fractionation and are thus likely to appear as a generic feature. Considering this as a plausible model for planetary mantle evolution it provides a dynamic explanation for the existence of distinct chemical reservoirs within the history of a planet’s mantle.
SoyOD: An Integrated Soybean Multi-omics Database for Mining Genes and Biological Research
Authors: Li Jie , Ni Qingyang , He Guangqi , Huang Jiale , Chao Haoyu , Li Sida , Chen Ming , Hu Guoyu , Whelan James , Shou Huixia 
Published: November 2024

Abstract
Soybean is a globally important crop for food, feed, oil, and nitrogen fixation. A variety of multi-omics studies have been carried out, generating datasets ranging from genotype to phenotype. In order to efficiently utilize these data for basic and applied research, a soybean multi-omics database with extensive data coverage and comprehensive data analysis tools was established. The Soybean Omics Database (SoyOD) integrates important new datasets with existing public datasets to form the most comprehensive collection of soybean multi-omics information. Compared to existing soybean databases, SoyOD incorporates an extensive collection of novel data derived from the deep-sequencing of 984 germplasms, 162 novel transcriptomic datasets from seeds at different developmental stages, 53 phenotypic datasets, and more than 2500 phenotypic images. In addition, SoyOD integrates existing data resources, including 59 assembled genomes, genetic variation data from 3904 soybean accessions, 225 sets of phenotypic data, and 1097 transcriptomic sequences covering 507 different tissues and treatment conditions. Moreover, SoyOD can be used to mine candidate genes for important agronomic traits, as shown in a case study on plant height. Additionally, powerful analytical and easy-to-use toolkits enable users to easily access the available multi-omics datasets, and to rapidly search genotypic and phenotypic data in a particular germplasm. The novelty, comprehensiveness, and user-friendly features of SoyOD make it a valuable resource for soybean molecular breeding and biological research. SoyOD is publicly accessible at https://bis.zju.edu.cn/soyod.