bluuebunny/crossref_metadata_2025_split huggingface dataset:
INDIСATORS OF THE LYMPHOCYTE SUBSETS AS EFFICICIENCY PREDICTORS OF THERAPY WITH INHIBITORS OF TNFα IN CHILDREN WITH INFLAMMATORY BOWEL DISEASE
Authors: Petrichuk S. V. , Miroshkina L. V. , Semikina E. L. , Toptygina A. P. , Potapov A. S. , Tsimbalova E. G. , Radygina T. V. 
Published: November 2018

(IBD), who were for the first time treated with TNFα blocker (infliximab). Our aim was to determine prognostic informative value of the immunological parameters in order to assess the treatment efficiency. A comprehensive research included seventy children with IBD from 12 to 18 years old in the course of specific treatment (49 children with CD, 21 children with UC).The comparison group consisted of fifty healthy children of similar age who were subjected to a similar detailed examination. The patients were divided into two groups, depending on their therapeutic response following 1 year of biological therapy: the first group showed a persistent positive effect of the drug, and the second group exhibited only unstable effects of the treatment. We determined the contents of major and small subpopulations of peripheral blood lymphocytes before the first administration of infliximab. Immunophenotyping was performed by multicolor flow cytometry (FC 500), using the CD45, CD3, CD4, CD8, CD19, CD16, CD56, HLA-DR, CD5, CD161, CD127, CD25, and CD294 markers.We have revealed that the content of B lymphocytes was significantly reduced in children with unstable effects of therapy. By contrast, the B lymphocyte levels in children with persistent positive therapeutic effect did not differ from the comparison group. Analysis of the composition of the B lymphocyte profile showed an imbalance in the B1-to-B2 cell ratio, with decreased of B1 cell counts in IBD patients against the comparison group. In addition, the patients with unstable therapeutic effect showed a significant decrease in B2 cell numbers compared with a group with persistent effect and comparison group. The numbers of NK cells in IBD patients were found to be reduced against the comparison group. Assessment of T lymphocytes subsets revealed a number of features in the patients with minimal therapeutic effects, i.e., an increased level of activated T helper cells (CD4+CD25+CD127high) and Th17 lymphocytes (CD3+CD4+CD161+), as compared to children with stable effect of treatment and to the comparison group. Moreover, in children with minimal effects of therapy, the levels of Tregs within T-helper cell subsets were significantly higher than in the comparison group. By means of ROC analysis, we have identified most informative parameters for the groups with minimal versus persistent therapeutic effect, and showed a good quality for a discrimination model involving relative amount of Th17 cells, activated T helper cells and B lymphocytes. The number of Тh17 lymphocytes (% CD3+CD4+ lymphocytes) allowed to predict the effect of therapy with a TNFα blocker with high probability. The present study enables us to propose cellular immunity testing, as a promising tool for monitoring clinical state of IBD patients.
A novel total body digital photography smartphone application designed to detect and monitor skin lesions: a pilot study
Authors: Guido Nicholas , Hagstrom Erika L. , Ibler Erin , Carneiro Chantelle , Orrell Kelsey A. , Kelm Ryan C. , Rademaker Alfred W. , West Dennis P. , Nardone Beatrice 
Published: November 2018

<p class="Body">Although some smartphone applications are designed for total body photography (TBP), few offer the specificity that enables self- as well as dermatologist-, detection of new lesions, or change in lesion color or in size as little as 1mm, on an ongoing basis. The aim of this study is to assess the sensitivity of a novel TBP application in the detection of changes to color and size of simulated skin lesions. Twenty-five subjects underwent one study visit. After baseline photography, new artificial markings were made or naturally occurring pigmented lesions located in any anatomical region were enhanced/enlarged, and a second matching set of photographs was then taken. From all 25 subjects, a total of 262 skin markings were evaluable. Of these, 241 (92%) were detected by the app, which resulted in an overall sensitivity of 92%. The high sensitivity establishes the app as capable of providing reliable self-TBP that allows detection and monitoring of new skin lesions or change in both size and color. This method greatly enhances the ability to accomplish ongoing self-monitoring and yet provides quality informing images to the dermatologist to assist in decision-making with the patient. </p>
Makerspaces and scientific creativity level of middle school students
Authors: Caballero García Presentación , Fernandez Trino Grau 
Published: November 2018

Being creative is something natural for children. However, as human beings advance in age, the ability to express creativity often decreases or even disappears. During adolescence is when people usually leave behind the creative freedom that was enjoyed in childhood. Makerspaces are spaces that offer tools and materials that encourage students to create. The purpose of this study is to investigate the effect of Makerspaces in scientific creativity level of eight grade students, using a quasi-experimental design pretest-posttest (Cook & Campbell, 1979). The participants of the research were 200 students who attend to a private school in Madrid during 2017-2018 academic years. The experimental groups selected covered the learning standards by doing a project in the makerspace, and the control groups covered the same standards by traditional learning in the classroom. To investigate scientific creativity of secondary school students, the Hu & Adey (2002) scale test was used. Our findings showed a significant difference in scientific creativity between the groups. The experimental group (maker-centered learning) had higher scientific creativity than control group (traditional learning). Authors such as Ramirez & Fuentes (2013) have shown that activities that help students to deal with real life situations, combined with methodologies of innovation that encourage creativity and promote the involvement and motivation of students, make them feel happier and help to develop students personally and professionally, as well as to improve their academic performance. We strongly recommend the use of makerspaces in schools as learning environments that will foster scientific creativity, influencing positively in the academic performance of students.

Keywords: Makerspaces; creativity; maker-centered learning; academic performance;
Development of youth professional interests in accordance with labour market requirements
Authors: Libkovska Una , Lusena - Ezera Inese 
Published: November 2018

This article analyses the European Commission, OECD and Eurostat data, and the Latvian labour market data on youth unemployment rates during 2008â€“2014. It also examines the results of the empirical study on the Latvian youthâ€™s development of creativity in the formation of intents about profession and its conformity with demands of the present labour market. For determination of the professional interest, methods of analysis and synthesis, time series analysis and mathematical statistics were applied. For the interpretation of models and facts, survey method, expert interview method, focus group discussion analysis, SWOT and PEST methods were applied. A questionnaire was used to examine the professional intents of youth from Latvian secondary schools, and a focus group discussion with parents and teachers of students was organised to determine concepts about the issues of vocational choice in the context of supply and demand in the labour market.

Keywords: Vocational choice, career, employment, labour market.
Brand positioning of domestic services in Australia
Authors: Zhechev Vladimir , Stanimirov Evgeni 
Published: November 2018

The purpose of this article (as part of a larger study) is to develop and apply a methodology for analysing and assessing the competitive position of the Fantastic Services Australia (FSA) brand in the surveyed country (and the major regional domestic services marketsâ€“â€“Melbourne and Sydney). Based on scientifically grounded analysis, theoretical ideas and exploration of FSA markets, the paper highlights some marketing prospects for the company and draws conclusions and guidelines for building an appropriate positioning strategy for the respective regions and types of services (end of lease cleaning, carpet cleaning and one-off cleaning). FSA is one of the largest market players, both in terms of scale and network of franchisees, and this coupled with the intensive rivalry it faces further elucidates the need for carefully calibrated brand positioning to maintain competitive edge.

Keywords: Brand positioning, positioning strategy, domestic services.
Significant leadership competencies at large industrial companies: Results of exploratory quantitative research
Authors: Mazanek Lukas , Vraniak Lukas , Murinova Anastsasia , Konecny Stepan 
Published: November 2018

The aim of this study is to identify important managerial competencies applied in large industrial enterprises established in the South Moravia region. The study was created on the basis of extensive research activities of competency-oriented publications, published in the last 15 years. Current scientific approaches to competence research, their composition and classification are described. The research was carried out on a sample of 24 managers. The significance of 25 competences was evaluated by using a 5-point Likert scale in the form of self-evaluation of the manager. The contribution of the presented study is an analysis of key concepts in the area of competency models and identification of stakeholders [Human Resource, managers, employees and society as a whole], including their relationship to the application of a competence approach. The identified most important managerial competencies in relation to the managerial level at which leaders work are used as a base for the creation of competence model in large industrial companies.

Keywords: Managerial competencies, quantitative research, leadership, competency model, personnel management.
Management of sports clubs in the town based on the principles of cooperation
Authors: Varmus Michal , Kubina Milan 
Published: November 2018

In the Slovakia are very many sports clubs that are civic associations. Within towns they are often as separate entity. Management of these sports clubs in the town is very specific. A town wants to have influence on these clubs, especially when the clubs are supported from municipal finance. In these paper we deal with possible management of clubs in the town within cooperation principle. We identified the main advantages, disadvantages, and points that are important for good established cluster of sports clubs in the town.

Keywords: sport; club; cooperation; town; management
Discovering future of the social trends using social media tools
Authors: Sevinc Omer , Askerbeyli Iman , Guzel Serdar Mehmet 
Published: November 2018

Social media has been widely used in our daily lives, which, in essence, can be considered as a magic box, providing great insights about world trend topics. It is a fact that inferences gained from social media platforms such as Twitter, Faceboook or etc. can be employed in a variety of different fields. Computer science technologies involving data mining, natural language processing (NLP), text mining and machine learning are recently utilized for social media analysis. A comprehensive analysis of social web can discover the trends of the public on any field. For instance, it may help to understand political tendencies, cultural or global believes etc. Twitter is one of the most dominant and popular social media tools, which also provides huge amount of data. Accordingly, this study proposes a new methodology, employing Twitter data, to infer some meaningful information to remarks prominent trend topics successfully. Experimental results verify the feasibility of the proposed approach.
Keywords: Social web mining, Tweeter analysis, machine learning, text mining, natural language processing.
Message from Editor
Authors: Ibrahim Prof. Dr. Dogan 
Published: November 2018

Message from Editor
Dear Readers,

It is a great honor for us to publish Volume 8, Issue 1 of Global Journal of Computer Sciences: Theory and Research.

Global Journal of Computer Sciences: Theory and Research (GJCS) is an international online journal for scientists and professionals involved in all aspects of computer sciences. This journal serves as an international platform that fosters theoretical and practical issues and new applications for all scientists and professionals from the field of computer sciences including original research and innovative applications from all parts of the world.

Aim of this issue is to give the researchers an opportunity to share the results of their academic studies. There are different research topics discussed in the articles. Articles focusing on performance analysis of software maintenance process using stochastic Petri nets, modelling and power control of grid connected wind energy system, study and identification of short-circuit currents at the complex distribution network SIDER EL Hadjar (ex ArceloMittal-Algerie), Bangladeshi consumersâ€™ e-commerce security and privacy satisfactions in small to mid-sized enterprises (SMEs), STATCOMâ€™s contribution to the improvement of voltage plan and power flow in an electrical transmission network and a technological platform for the creation and evaluation of psycho-technical tests are included in the current issue.

A total number of twelve (12) manuscripts were submitted for this issue and each paper has been subjected to double-blind peer review process by the reviewers specialized in the related field. At the end of the review process, a total number of six (6) high quality research papers were selected and accepted for publication.

We present many thanks to all the contributors who helped us to publish this issue.

Best regards,

Prof. Dr. Dogan Ibrahim

Editor â€“ in Chief
Modelling and power control of grid-connected wind energy system
Authors: Si Ali Nadia Ben , Zerzouri Nora , Benalia Nadia 
Published: November 2018

Wind energy generation has attracted great interests in recent years. Doubly Fed Induction Generator (DFIG) for wind turbines are largely deployed because variable-speed wind turbines have many advantages over fixed-speed generation such as increased energy capture, operation at maximum power point, improved efficiency, and power quality. This paper presents the operation and vector control of a Doubly-fed Induction Generator (DFIG) system where the stator is connected directly to a stiff grid and the rotor is connected to the grid through bidirectional back-to-back AC-DC-AC converter. The basic operational characteristics , mathematical model of the aerodynamic system and vector control technique which is used to obtain decoupled control of powers are investigated using the software Matlab/Simulink.
Performance Analysis and Automatic Prototype Aquaponic of System Design Based on Internet of Things (IoT) using MQTT Protocol
Authors: Ratnasih Ratnasih , Perdana Doan , Bisono Yoseph Gustommy 
Published: November 2018

The Aquaponic is a farming system which need of attention because their system will mutually influence each other. Then using IoT technologies, can be made aquaponic that can automatically control and monitoring the aquaponic. The prototype using nodeMCU as a microcontroller, and for communication, the system using MQTT protocol and android application as a user interface. The purpose of this research is to provide convenience for aquaponic user to be able to control remotely. In addition, this research aims is to analysis the QoS performance of the prototype. This research uses 2 scenario testing, there is with changing the distance between sensor nodes and access point, and testing the system in a normal state. Based on the results of the testing that has been done, the farther the distance range of the sensors node with access point then declining system performance. But in the normal state test, the median value of the mean delay was 0.10512s and the median value average throughput is 566 Bytes/s. In addition the median value also obtained the mean availibity and realibity system that is 98.258% and 98.204%. Refers to the standard TIPHON (DTR/TIPHON-05001), the QoS performance of this system include excellent category.
“Un Geste Suffit”? Unpacking the Inconvenient Truths about Al Gore’s Celebrity Activism
Authors: Marshall David , D'Cruz Glenn , Mcdonald Sharyn 
Published: November 2018

The present work interrogates Al Gore’s persona as a climate change activist with reference to a process we describe with the neologism “personafication”: the act of constructing/presenting a public persona in order to cultivate impressions that enable public figures to consolidate authoritative reputations. The formation of such a commanding persona requires the circulation of three forms of symbolic capital: cultural, celebrity, and reputational capital as well as the performance of overtly theatrical strategies calculated to establish an empathetic relationship between performer and audience. In 2006, former Vice President Al Gore released the award-winning documentary, An Inconvenient Truth. This film subsequently functioned as a catalyst for various forms of climate change activism. This paper unpacks the contradictory ideological and cultural work performed by the film with reference to what we describe as un geste suffit; that is, those gestures that merely perform individual agency in order to connect the formulation of personal ethical identity to communal forms of political activism like environmentalism. Through a close reading of the presentation of Gore’s persona in the film itself, and research which tracks the reception and political efficacy of the film, the paper contributes to the growing body of scholarship on the politics of environmental/scientific communication. Finally, we locate our reading of Gore’s film within a contemporary context by making reference to the way An Inconvenient Truth is both resistant to and complicit with the environmental policies of the Trump administration.
Advances in the Understanding of the Cannabinoid Receptor 1 – Focusing on the Inverse Agonists Interactions
Authors: Russo Silvana , De Azevedo Walter Filgueira 
Published: November 2018

Background:
Cannabinoid Receptor 1 (CB1) is a membrane protein prevalent in
the central nervous system, whose crystallographic structure has recently been solved. Studies
will be needed to investigate CB1 complexes with its ligands and its role in the development
of new drugs.

Objective:
Our goal here is to review the studies on CB1, starting with general aspects and
focusing on the recent structural studies, with emphasis on the inverse agonists bound structures.

Methods:
We start with a literature review, and then we describe recent studies on CB 1 crystallographic
structure and docking simulations. We use this structural information to depict
protein-ligand interactions. We also describe the molecular docking method to obtain complex
structures of CB 1 with inverse agonists.

Results:
Analysis of the crystallographic structure and docking results revealed the residues
responsible for the specificity of the inverse agonists for CB 1. Most of the intermolecular interactions
involve hydrophobic residues, with the participation of the residues Phe 170 and
Leu 359 in all complex structures investigated in the present study. For the complexes with
otenabant and taranabant, we observed intermolecular hydrogen bonds involving residues His
178 (otenabant) and Thr 197 and Ser 383 (taranabant).

Conclusion:
Analysis of the structures involving inverse agonists and CB 1 revealed the pivotal
role played by residues Phe 170 and Leu 359 in their interactions and the strong intermolecular
hydrogen bonds highlighting the importance of the exploration of intermolecular interactions
in the development of novel inverse agonists.
Design and Synthesis of Indole Pyrimidine Scaffolds as Potential KSP Inhibitors and Anticancer Agents
Authors: Chelamalla Radhika , Makula Ajitha 
Published: November 2018

Background:
Several biological activities like anticancer, anti-inflammatory, analgesic,
antitubercular activities are reported for pyrimidine scaffolds. Extensive work on pyrimidine indole
scaffolds is required for antimitotic activity.

Objective:
To synthesize a novel Indole Pyrimidine scaffold via an efficient synthetic method and to
evaluate cytotoxic activity using various human cancer cell lines.

Methods:
4,4-(3-substituted phenyl)-6-methyl-N-[(Z)-(5-methyl-2-oxo-indolin-3-ylidene)amino]-2-
oxo-3,4-dihydro-1H-pyrimidine-5-carboxamide derivatives were designed, synthesized and evaluated
for cytotoxic activity. The structures were confirmed by IR, 1H NMR, C13NMR and Mass spectroscopy.
The antiproliferative activities of the synthesized compounds were evaluated in vitro
against human cancer cell lines including HeLa and MCF-7.

Results:
The results revealed that most of the compounds possessed moderate to excellent potency.
Three among 10 molecules, showed more than 70% growth inhibition against all tested cancer cells.
The nature of the substituent group (R) on the indole ring affected significantly the anti-proliferative
activity of the molecules. The IC50 values of the most promising compound 4h are 76.4µM and
88.2µM against HeLa and MCF-7 respectively, which are closer to the standard compound doxorubicin.

Conclusion:
Molecular docking analysis demonstrated that 4b and 4d interact and bind efficiently
with KSP binding site. The preliminary results made us investigate for further development of potent
indole-pyrimidine scaffolds as cytotoxic agents
Simultaneous Determination of 17 Constituents of Chinese Wild Radix Salvia miltiorrhiza from Different Geographical Areas by Ultra-High Performance Liquid Chromatography Coupled to Triple Quadrupole Mass Spectrometry
Authors: Zhang Xiao-Dan , Cen Ye-Sheng , Yu Yan-Ge , Qi Zhe-Chen , Yang Dong-Feng , Wang Zi-Ying , Hou Zhuo-Ni , Liang Zong-Suo 
Published: November 2018

Background and Objective:
Radix Salvia miltiorrhiza (RSM) has been used clinically for the
prevention and treatment of cardiovascular diseases; therefore, it is important to strengthen its quality
management. Considering multiple constituents when assessing RSM quality is essential. We established
a simple, rapid method to identify and quantify the major bioactive constituents in RSM using
ultra high performance liquid chromatography (UPLC) coupled to a triple quadruple mass spectrometry
(QqQ-MS).

Methods:
We analyzed 17 markers from 50 batches of wild S. miltiorrhiza samples that were collected
from different locations in China. The ultrasonic extracts of all samples were determined using the
UPLC-QqQ-MS method and were assessed by hierarchical cluster analysis (HCA).

Results:
We used this method to analyze 50 sample batches of the 17 compounds and obtained results
with excellent linearity (R2, 0.9915-0.9997), precision (relative standard deviation, RSD, 0.15-1.94%),
repeatability (RSD, 1.28-4.71%), stability (RSD, 0.97-5.60%) and recovery (RSD, 0.305-6.40%). The
hierarchical cluster analysis was used to classify the 50 samples based on the characteristics of the 17
compound markers.

Conclusion:
We demonstrated that the developed method was simple, reproducible and sensitive, and it
is capable of systematic and scientific evaluation for quality control of RSM. The HCA clearly demonstated
that the RSM samples from different locations were significantly different and the quality of wild
Radix S. miltiorrhiza could generally be judged according to its geographical origin.