bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development and validation of a risk scoring system based on baseline angiographic results by visual estimation for risk prEdiction of side‐branch OccLusion in coronary bifurcation InterVEntion: The baseline V‐RESOLVE score
Authors: He Yuan , Zhang Dong , Yin Dong , Zhu Chenggang , Feng Lei , Song Chenxi , Chen Changzhe , Feng Lei , Dou Kefei 
Published: January 2019

ObjectiveWe aimed to adapt the visual estimation for Risk prEdiction of side‐branch OccLusion in coronary bifurcation interVEntion (V‐RESOLVE) score to enable risk prediction for side‐branch (SB) occlusion using only baseline coronary angiogram data.BackgroundThe V‐RESOLVE score, which comprises angiographic factors at baseline and after lesion preparation, is a validated tool for predicting SB occlusion risk in coronary bifurcation intervention.MethodsTo develop and validate the new scoring system, we used data pertaining to 1,545 patients and another 1,286 consecutive patients. Baseline V‐RESOLVE was derived from V‐RESOLVE by replacing the two pre‐stenting angiographic factors with the corresponding preprocedural characteristics, while maintaining the scoring standard itself. We evaluated the diagnostic performance of baseline V‐RESOLVE for predicting SB occlusion and preformed risk stratification with characterization of non‐high‐risk and high‐risk lesions.ResultsThe area under the receiver operating characteristic curves was similar between baseline V‐RESOLVE and V‐RESOLVE (0.735 vs 0.756, P = 0.191), with good calibration for baseline V‐RESOLVE (Hosmer‐Lemeshow P = 0.714). Upon categorization by the baseline V‐RESOLVE score, high‐risk lesions (score: 14–43) demonstrated significantly higher rate of SB occlusion than did non‐high‐risk lesions (score: 0–13) (17.31% vs 4.74%, P < 0.01). Considering the V‐RESOLVE‐based risk stratification as reference, baseline V‐RESOLVE had an integrated discrimination index of −1.81% (P = 0.052), and net reclassification improvement of −3.34% (P = 0.509). Upon validation, baseline V‐RESOLVE provided satisfactory diagnostic performance and risk stratification.ConclusionsBaseline V‐RESOLVE predicts SB occlusion in coronary bifurcation intervention based solely on the preprocedural angiographic results.
Angiographic predictors of adverse outcomes after percutaneous coronary intervention in patients with radiation associated coronary artery disease
Authors: Reed Grant W. , Rossi Jeffrey E. , Masri Ahmad , Griffin Brian P. , Ellis Stephen G. , Kapadia Samir R. , Desai Milind Y. 
Published: January 2019

AbstractObjectivesTo determine procedural predictors of long‐term outcomes for patients with radiation associated coronary artery disease (CAD) treated with percutaneous coronary intervention (PCI).BackgroundPatients who develop CAD after external beam radiation therapy (XRT) for cancer are at high‐risk for adverse events following PCI. It is unknown if specific angiographic features can predict outcomes in this population.MethodsThis is an observational study of 157 patients with malignancy who received XRT prior to PCI. Rates of major adverse cardiovascular and cerebrovascular events (MACCEs; all‐cause mortality, myocardial infarction, repeat revascularization, or stroke) were compared across patient characteristics over time with the Cox proportional hazards and Kaplan–Meier's analyses.ResultsDuring follow‐up of 5.4 ± 4.5 years, 91 (58%) patients had MACCE. On Kaplan–Meier's analysis of angiographic characteristics, MACCE was more frequent in patients with at least moderate target vessel calcification (P = 0.023), ostial stenosis (P = 0.049), target vessel diameter ≥ 3.0 mm (P = 0.018), a SYNTAX score ≥ the median of 11 (P = 0.014), or bare metal stenting (BMS)/balloon angioplasty (BA) compared to drug‐eluting stenting (DES) (P = 0.006). Cardiac death was more frequent in patients with SYNTAX score ≥ 11 (P = 0.028) or BMS (P = 0.043). After multivariable adjustment for both angiographic and clinical characteristics, independent predictors of MACCE were BMS placement (P = 0.013), chronic kidney disease ≥ stage 3 (P = 0.019), New York Heart Association (NYHA) heart failure class ≥3 (P = 0.034), and SYNTAX score ≥ 11 (P = 0.041).ConclusionsIn patients previously exposed to XRT treated with PCI, independent angiographic predictors of MACCE include SYNTAX score ≥ 11 and BMS placement, suggestive that DES should be preferred in this population.
Sutureless repair of spontaneous coronary dissection with free wall rupture and cardiac tamponade
Authors: Gannon Michael P. , Graver L. Michael , Singh Avneet 
Published: January 2019

AbstractLeft ventricular free wall rupture is a feared complication of acute myocardial infarction typically presenting with cardiogenic shock. We present a case of spontaneous coronary artery dissection with free wall rupture and cardiac tamponade in an uncommon demographic. Friable myocardial tissue frequently precludes suture technique making biological glue repair a suitable option.
β‐MnO2/Metal–Organic Framework Derived Nanoporous ZnMn2O4 Nanorods as Lithium‐Ion Battery Anodes with Superior Lithium‐Storage Performance
Authors: Pang Fang , Hou Shuang , Wang Pu , Liu Miao , Luo Yizhen , Zhao Lingzhi 
Published: January 2019

AbstractNanoporous ZnMn2O4 nanorods have been successfully synthesized by calcining β‐MnO2/ZIF‐8 precursors (ZIF‐8 is a type of metal–organic framework). If measured as an anode material for lithium‐ion batteries, the ZnMn2O4 nanorods exhibit an initial discharge capacity of 1792 mA h g−1 at 200 mA g−1, and an excellent reversible capacity of 1399.8 mA h g−1 after 150 cycles (78.1 % retention of the initial discharge capacity). Even at 1000 mA g−1, the reversible capacity is still as high as 998.7 mA h g−1 after 300 cycles. The remarkable lithium‐storage performance is attributed to the one‐dimensional nanoporous structure. The nanoporous architecture not only allows more lithium ions to be stored, which provides additional interfacial lithium‐storage capacity, but also buffers the volume changes, to a certain degree, during the Li+ insertion/extraction process. The results demonstrate that nanoporous ZnMn2O4 nanorods with superior lithium‐storage performance have the potential to be candidates for commercial anode materials in lithium‐ion batteries.
One‐Step Fabrication of Bio‐Compatible Coordination Complex Film on Diverse Substrates for Ternary Flexible Memory
Authors: Sun Wu‐Ji , Zhao Yong‐Yan , Zhou Jin , Cheng Xue‐Feng , He Jing‐Hui , Lu Jian‐Mei 
Published: January 2019

AbstractRecently, resistance random access memories (RRAMs) have been studied extensively, because the demand for information storage is increasing. However, it remains challenging to obtain a flexible device because the active materials involved need to be nontoxic, nonpolluting, distortion‐tolerable, and biodegradable as well adhesive to diverse flexible substrates. In this paper, tannic acid (TA) and an iron ion (FeIII) coordination complex were employed as the active layer in a sandwich‐like (Al/active layer/substrate) device to achieve memory performance. A nontoxic, biocompatible TA‐FeIII coordination complex was synthesized by a one‐step self‐assembly solution method. The retention time of the TA‐FeIII memory performance was up to 15 000 s, the yield up to 53 %. Furthermore, the TA‐FeIII coordination complex can form a high‐quality film and shows stable ternary memory behavior on various flexible substrates, such as polyethylene terephthalate (PET), polyimide (PI), printer paper, and leaf. The device can be degraded by immersing it in vinegar solution. Our work will broaden the application of organic coordination complexes in flexible memory devices with diverse substrates.
Probing the Proton‐Coupled Electron‐Transfer (PCET) Reactivity of a Cross‐Conjugated Cruciform Chromophore by Redox‐State‐Dependent Fluorescence
Authors: Wagner Conrad , Hübner Olaf , Kaifer Elisabeth , Himmel Hans‐Jörg 
Published: January 2019

AbstractProton‐coupled electron transfer (PCET) reactions are of great importance in synthetic chemistry and in biology, but the acquisition of kinetic information for these reactions is often difficult. Herein, we report the synthesis of a new PCET reagent, showing redox‐state dependent fluorescence, by merging the concept of cross‐conjugated cruciform chromophores with the strategy of imposing redox activity and Brønsted basicity to aromatic compounds by substitution with guanidino groups. The compound is isolated and characterized in all stable states—reduced, twofold and fourfold protonated and twofold oxidized—and then applied in PCET reactions by using its redox‐state dependent fluorescence signal for kinetic measurements.
Evaluation of medial division of the medial geniculate (MGM) and posterior intralaminar nucleus (PIN) inputs to the rat auditory cortex, amygdala, and striatum
Authors: Smith Philip H. , Uhlrich Daniel J. , Manning Karen A. 
Published: January 2019

AbstractThe medial division of the medial geniculate (MGM) and the posterior intralaminar nucleus (PIN) are association nuclei of the auditory thalamus. We made tracer injections in these nuclei to evaluate/compare their presynaptic terminal and postsynaptic target features in auditory cortex, amygdala and striatum, at the light and electron microscopic levels. Cortical labeling was concentrated in Layer 1 but in other layers distribution was location‐dependent. In cortical areas designated dorsal, primary and ventral (AuD, Au1, AuV) terminals deep to Layer 1 were concentrated in infragranular layers and sparser in the supragranular and middle layers. In ectorhinal cortex (Ect), distributions below Layer 1 changed with concentrations in supragranular and middle layers. In temporal association cortex (TeA) terminal distributions below Layer 1 was intermediate between AuV/1/D and Ect. In amygdala and striatum, terminal concentrations were higher in striatum but not as dense as in cortical Layer 1. Ultrastructurally, presynaptic terminal size was similar in amygdala, striatum or cortex and in all cortical layers. Postsynaptically MGM/PIN terminals everywhere synapsed on spines or small distal dendrites but as a population the postsynaptic structures in cortex were larger than those in the striatum. In addition, primary cortical targets of terminals were larger in primary cortex than in area Ect. Thus, although postsynaptic size may play some role in changes in synaptic influence between areas it appears that terminal size is not a variable used for that purpose. In auditory cortex, cortical subdivision‐dependent changes in the terminal distribution between cortical layers may also play a role.
Optimization of Receptor Occupancy Assays in Mass Cytometry: Standardization Across Channels with QSC Beads
Authors: Bringeland Gerd Haga , Bader Lucius , Blaser Nello , Budzinski Lisa , Schulz Axel R. , Mei Henrik E. , Myhr Kjell‐Morten , Vedeler Christian A. , Gavasso Sonia 
Published: January 2019

AbstractReceptor occupancy, the ratio between amount of drug bound and amount of total receptor on single cells, is a biomarker for treatment response to therapeutic monoclonal antibodies. Receptor occupancy is traditionally measured by flow cytometry. However, spectral overlap in flow cytometry limits the number of markers that can be measured simultaneously. This restricts receptor occupancy assays to the analysis of major cell types, although rare cell populations are of potential therapeutic relevance. We therefore developed a receptor occupancy assay suitable for mass cytometry. Measuring more markers than currently available in flow cytometry allows simultaneous receptor occupancy assessment and high‐parameter immune phenotyping in whole blood, which should yield new insights into disease activity and therapeutic effects. However, varying sensitivity across the mass cytometer detection range may lead to misinterpretation of the receptor occupancy when drug and receptor are detected in different channels. In this report, we describe a method for optimization of mass cytometry receptor occupancy measurements by using antibody‐binding quantum simply cellular (QSC) beads for standardization across channels with different sensitivities. We evaluated the method in a mass cytometry‐based receptor occupancy assay for natalizumab, a therapeutic antibody used in multiple sclerosis treatment that binds to α4‐integrin, which is expressed on leukocyte cell surfaces. Peripheral blood leukocytes from a treated patient were stained with a panel containing metal‐conjugated antibodies for detection of natalizumab and α4‐integrin. QSC beads with known antibody binding capacity were stained with the same metal‐conjugated antibodies and were used to standardize the signal intensity in the leukocyte sample before calculating receptor occupancy. We found that QSC bead standardization across channels corrected for sensitivity differences for detection of drug and receptor and generated more accurate results than observed without standardization. © 2019 The Authors. Cytometry Part A published by Wiley Periodicals, Inc. on behalf of International Society for Advancement of Cytometry.
An efficient algorithm for dynamic task offloading using cloudlets in mobile cloud computing
Authors: D Shobha Rani , M Pounambal , V Saritha 
Published: January 2019

SummaryIt is a visible fact that the growth of mobile devices is enormous. More computations are required to be carried out for various applications in these mobile devices. But the drawback of the mobile devices is less computation power and low available energy. The mobile cloud computing helps in resolving these issues by integrating the mobile devices with cloud technology. Again, the issue is increased in the latency as the task and data to be offloaded to the cloud environment uses WAN. Hence, to decrease the latency, this paper proposes cloudlet‐based dynamic task offloading (CDTO) algorithm where the task can be executed in device environment, cloudlet environment, cloud server environment, and integrated environment. The proposed algorithm, CDTO, is tested in terms of energy consumption and completion time.
Potential limitations of behavioral plasticity and the role of egg relocation in climate change mitigation for a thermally sensitive endangered species
Authors: Liles Michael J. , Peterson Tarla Rai , Seminoff Jeffrey A. , Gaos Alexander R. , Altamirano Eduardo , Henríquez Ana V. , Gadea Velkiss , Chavarría Sofía , Urteaga José , Wallace Bryan P. , Peterson Markus J. 
Published: January 2019

AbstractAnthropogenic climate change is widely considered a major threat to global biodiversity, such that the ability of a species to adapt will determine its likelihood of survival. Egg‐burying reptiles that exhibit temperature‐dependent sex determination, such as critically endangered hawksbill turtles (Eretmochelys imbricata), are particularly vulnerable to changes in thermal regimes because nest temperatures affect offspring sex, fitness, and survival. It is unclear whether hawksbills possess sufficient behavioral plasticity of nesting traits (i.e., redistribution of nesting range, shift in nesting phenology, changes in nest‐site selection, and adjustment of nest depth) to persist within their climatic niche or whether accelerated changes in thermal conditions of nesting beaches will outpace phenotypic adaption and require human intervention. For these reasons, we estimated sex ratios and physical condition of hatchling hawksbills under natural and manipulated conditions and generated and analyzed thermal profiles of hawksbill nest environments within highly threatened mangrove ecosystems at Bahía de Jiquilisco, El Salvador, and Estero Padre Ramos, Nicaragua. Hawksbill clutches protected in situ at both sites incubated at higher temperatures, yielded lower hatching success, produced a higher percentage of female hatchlings, and produced less fit offspring than clutches relocated to hatcheries. We detected cooler sand temperatures in woody vegetation (i.e., coastal forest and small‐scale plantations of fruit trees) and hatcheries than in other monitored nest environments, with higher temperatures at the deeper depth. Our findings indicate that mangrove ecosystems present a number of biophysical (e.g., insular nesting beaches and shallow water table) and human‐induced (e.g., physical barriers and deforestation) constraints that, when coupled with the unique life history of hawksbills in this region, may limit behavioral compensatory responses by the species to projected temperature increases at nesting beaches. We contend that egg relocation can contribute significantly to recovery efforts in a changing climate under appropriate circumstances.
The influence of warming on the biogeographic and phylogenetic dependence of herbivore–plant interactions
Authors: Mu Xidong , Xu Meng , Ricciardi Anthony , Dick Jaimie T. A. , Luo Du , Wei Hui , Hu Yinchang , Wei Qiwei 
Published: January 2019

AbstractEvolutionary experience and the phylogenetic relationships of plants have both been proposed to influence herbivore–plant interactions and plant invasion success. However, the direction and magnitude of these effects, and how such patterns are altered with increasing temperature, are rarely studied. Through laboratory functional response experiments, we tested whether the per capita feeding efficiency of an invasive generalist herbivore, the golden apple snail,Pomacea canaliculata, is dependent on the biogeographic origin and phylogenetic relatedness of host plants, and how increasing temperature alters these dependencies. The feeding efficiency of the herbivore was highest on plant species with which it had no shared evolutionary history, that is, novel plants. Further, among evolutionarily familiar plants, snail feeding efficiency was higher on those species more closely related to the novel plants. However, these biogeographic dependencies became less pronounced with increasing temperature, whereas the phylogenetic dependence was unaffected. Collectively, our findings indicate that the susceptibility of plants to this invasive herbivore is mediated by both biogeographic origin and phylogenetic relatedness. We hypothesize that warming erodes the influence of evolutionary exposure, thereby altering herbivore–plant interactions and perhaps the invasion success of plants.
Impact of cardiac myosin light chain kinase gene mutation on development of dilated cardiomyopathy
Authors: Hodatsu Akihiko , Fujino Noboru , Uyama Yuki , Tsukamoto Osamu , Imai‐Okazaki Atsuko , Yamazaki Satoru , Seguchi Osamu , Konno Tetsuo , Hayashi Kenshi , Kawashiri Masa‐aki , Asano Yoshihiro , Kitakaze Masafumi , Takashima Seiji , Yamagishi Masakazu 
Published: January 2019

AbstractAimsCardiac myosin light chain kinase (cMLCK) phosphorylates ventricular myosin regulatory light chain 2 (MLC2v) and regulates sarcomere and cardiomyocyte organization. However, few data exist regarding the relationship between cMLCK mutations and MLC2v phosphorylation, particularly in terms of developing familial dilated cardiomyopathy (DCM) in whom cMLCK gene mutations were identified. The purpose of the present study was to investigate functional consequences of cMLCK mutations in DCM patients.Methods and resultsThe diagnosis of DCM was based on the patients' history and on echocardiography. We screened cMLCK gene mutations in DCM probands with high resolution melting analysis. Known DCM‐causing genes mutations were excluded by exome sequencing of family members. MLC2v phosphorylation was analysed by Phos‐tag sodium dodecyl sulfate–polyacrylamide gel electrophoresis assays. We also performed ADP‐Glo assays for determining the total amount of adenosine triphosphate used in the kinase reaction. Unrelated DCM probands (109 males and 40 females) were enrolled in this study, of which 16 were familial and 133 sporadic. By mutation screening, a truncation variant of c1915‐1 g>t (p.Pro639Valfs*15) was identified, which was not detected in 400 chromosomes of 200 healthy volunteers; it is listed in the Human Genetic Variation Database with an allele frequency < 0.001. In the proband, the presence of mutations in known DCM‐causing genes was excluded with exome analysis. Familial analysis identified a 19‐year‐old male carrier who manifested slight left ventricular dilation with preserved systolic function. Phosphorylation assays analysed by Phos‐tag SDS‐PAGE revealed that the identified p.Pro639Valfs*15 mutation results in a complete lack of kinase activity, although it did not affect wild‐type cMLCK activity. ADP‐Glo assays confirmed that the mutant cMLCK had no kinase activity, whereas wild‐type cMLCK had a Km value of 5.93 ± 1.47 μM and a Vmax of 1.28 ± 0.03 mol/min/mol kinase.ConclusionsThese results demonstrate that a truncation mutation in the cMLCK gene p.Pro639Valfs*15 can be associated with significant impairment of MLC2v phosphorylation and possibly with development of DCM, although a larger study of DCM patients is required to determine the prevalence of this mutation and further strengthen its association with disease development.
Click regulation of cyclodextrin primary face for the preparation of novel chiral stationary phases
Authors: Jin Xuan , Li Xiaoxuan , Wang Yong 
Published: January 2019

AbstractIn this study, a series of novel CD chiral stationary phases were fabricated by immobilization of mono‐6A‐deoxy‐N3‐cyclodextrin onto silica surfaces followed by click regulation of CD primary face with 4‐pentynoic acid (acidic moiety), 2‐propynylamine (alkaline moiety) and L‐propargylglycine (chiral amino acid moiety), respectively. Enantioseparations of various kinds of racemates including dansyl‐amino acids, chiral lactides and diketones were conducted in reversed phase modes on these chiral stationary phases, where nearly forty diketones and chiral lactides were firstly separated on cyclodextrin stationary phases. 4‐Pentynoic acid moiety can make the retention ability decline while amine moiety significantly enhanced the retention ability of the stationary phases. For most of the studied analytes, the chiral amino acid moiety had the most positive effects on both the retention time and the resolution. The inclusion complexation between chiral analytes and cyclodextrins were also investigated by fluorescence method.
Methods for studying cultural attraction
Authors: Heintz Christophe , Blancke Stefaan , Scott‐Phillips Thom 
Published: January 2019

AbstractCultural attraction theory (CAT) describes a general evolutionary process, cultural attraction, by which the spread and stability of cultural items (beliefs, practices, artifacts, etc.) result not just from differential reproduction, but also from transformations that systematically favor the reconstruction of cultural items of specific types. In this way, CAT aims to provide a general framework for the study of cultural evolution. In a thoughtful critical analysis, Buskell questions the ability of CAT to provide methodological guidance for research in cultural evolution. Can CAT be used to develop the sort of mid‐range theories and models that often drive empirical work? Here we argue that CAT can indeed be used in this way, and we outline the methodological practices that students of cultural attraction have used and are currently developing.