bluuebunny/crossref_metadata_2025_split huggingface dataset:
PEWARISAN NILAI TRADISI NGABUNGBANG DALAM PEMBELAJARAN SEJARAH LOKALDENGAN METODE EKSKURSI PADA MAHASISWA PROGRAM STUDI PENDIDIKAN SEJARAH FKIP UNIVERSITAS GALUH
Authors: Sondarika Wulan , Wijayanti Yeni , Budiman Agus 
Published: January 2019

AbstractThe specific purpose of this research is to know the historical values in Ngabungbang Tradition and to know the extent of the inheritance of historical values Ngabungbang tradition applied in learning history using excursion method.This research was conducted in History Studies Program History FKIP Galuh Ciamis University, case study in the first grade students, using qualitative descriptive research method. Data collection is done by observation, interview, and document analysis. The results showed that Ngabungbang Tradition was held every 14 months Maulud in Batulawang Village, Pataruman Sub District, Banjar City. The values of the Ngabungbang Tradition are religious, aesthetic, economical, social, disciplinary, democratic, creative, honesty, homeland and other values. Most students can understand the values contained in the Ngabungbang Tradition. Keywords: Historical Value, Ngabungbang Tradition, Local History, Excursion
PENDIDIKAN KARAKTER BERBASIS KEARIFAN LOKAL PADA MATA KULIAH PERSPEKTIF GLOBAL
Authors: Kumalasari Dyah 
Published: January 2019

ABSTRACT Actualization of the value of character education based on local wisdom in the course of global perspective is done in order to equip students with noble values of the nation's culture to face the swift current of globalization. Javanese ethical values such as the principle of harmony and honor principles are presented as a study material that is an important part in discussing social changes and lifestyles of society in the global era. Included in this study is the study of the typical local wisdom of the people around Yogyakarta. The student's positive response indicates that the cultural values of our ancestral heritage still allow us to lift and revive in order to fortify the young generation today from the negative effects of global culture, since this course presents many insights into global culture that leads to pop culture, . Giving awareness to students about real-world phenomena behind the meaning of words from globalization, including discussing many things about current global issues, will be more effective if done by cultivating character education based on local wisdom. Keywords: character education, culture, local wisdom, global perspective
PENANAMAN NILAI-NILAI NASIONALISME DALAM PEMBELAJARAN SEJARAH DI SMA NEGERI 2 WATES, KULON PROGO
Authors: Rochmat Saefur , Trisnawati Diana 
Published: January 2019

AbstractThis study aims to: (1) Outlining the history of the learning process in SMA Negeri 2 Wates, Kulon Progo, and (2) Describe efforts to inculcate nationalism in the teaching of history in SMA Negeri 2 Wates, Kulon Progo. The method used in this research is descriptive qualitative research method. The data collection is done through in-depth interviews, direct observation and recording of documents. The results showed that the teaching of history in SMA Negeri 2 Wates do in the classroom during school hours and outside the classroom takes place through extra-curricular activities. Teachers deliver material as specified in the curriculum with the methods and media that support student success. Planting the values of nationalism done in several ways, namely to integrate in subjects such as history subjects, and the subjects Civics. In addition, the values of nationalism is also implanted through habituation attitude in the school environment, such as mutual cooperation, courtesy, tolerance, and so on. Keywords: Nationalism, Teaching History, SMA Negeri 2 Wates.
PENERAPAN KURIKULUM 2013 PADA MATA PELAJARAN SEJARAH PADA SEKOLAH MENENGAH ATAS
Authors: Agustinova Danu Eko 
Published: January 2019

Penelitian ini bertujuan untuk mengkaji: (1) penerapan kurikulum 2013 dibeberapa sekolah di indonesia, (2) kedudukan mata pelajaran sejarah dalam kurikulum 2013, dan (3) evaluasi penerapan mata pelajaran sejarah pada kurikulum 2013 yang ada dibeberapa sekolah menegah atas di indonesia. Penelitian ini menggunakan metode kajian literatur dan penelitian kualitatif dengan data sekunder dalam mendapatkan sumber-sumber data untuk penyusunannya. Hasil penelitian menunjukkan: (1) kurikulum 2013 merupakan kurikulum yang berbasis kompetensi dan karakter, (2) sejarah merupakan mata pelajaran yang mendapatkan amanat sebagai mata pelajaran pendidikan karakter dalam kurikulum 2013, (3) dalam penerapannya, mata pelajaran sejarah telah berhasil menjalankan amanat kurikulum 2013 yang berbasis pada kompetensi dan karakter, akan tetapi di dalam penerapannya terdapat hal-hal yang masih perlu diperbaiki dan ditingkatkan, seperti sarana prasarana, metode pembelajaran, dan lain sebagainya.
Trimethylamine N-Oxide and Cardiovascular Outcomes in Patients with ESKD Receiving Maintenance Hemodialysis
Authors: Stubbs Jason R. , Stedman Margaret R. , Liu Sai , Long Jin , Franchetti Yoko , West Raymond E. , Prokopienko Alexander J. , Mahnken Jonathan D. , Chertow Glenn M. , Nolin Thomas D. 
Published: January 2019

Background and objectives
Trimethylamine N-oxide (TMAO), a compound derived from byproducts of intestinal bacteria, has been shown to accelerate atherosclerosis in rodents. To date, there are conflicting data regarding the association of serum TMAO with cardiovascular outcomes in patients with ESKD, a population exhibiting both high serum TMAO and excessive atherosclerosis.

Design, setting, participants, & measurements
We measured baseline serum TMAO concentrations in a subset of participants (n=1243) from the Evaluation of Cinacalcet Hydrochloride Therapy to Lower Cardiovascular Events (EVOLVE) trial and conducted post hoc analyses evaluating the association between baseline serum TMAO and cardiovascular outcomes.

Results
We observed a wide distribution of serum TMAO in our cohort, with approximately 80% of participants exhibiting TMAO concentrations ≥56 µM and a maximum TMAO concentration of 1103.1 µM. We found no association between TMAO and our primary outcome, a composite of cardiovascular mortality, myocardial infarction, peripheral vascular event, stroke, and hospitalization for unstable angina. Moreover, in unadjusted and adjusted analyses, we observed no relation between TMAO and all-cause mortality, the independent components of our composite outcome, or the original EVOLVE primary outcome. Although we did observe higher TMAO concentrations in white participants, further subgroup analyses did not confirm the previously identified interaction between TMAO and race observed in a prior study in patients receiving dialysis.

Conclusions
We found no evidence linking TMAO to adverse clinical outcomes in patients receiving maintenance hemodialysis with moderate to severe secondary hyperparathyroidism.
La influencia del compromiso organizacional y orientación al aprendizaje sobre la innovación en las PYMES
Authors: Martínez Serna Maria Del Carmen , Vega Martínez Javier Eduardo , Eternod Domenech Vivian 
Published: January 2019

<p>Innovation is a strategic capacity for organizations as they face new and greater challenges, such as processing a vast amount of information and knowledge, as well as responding quickly to increasingly uncertain changing environments. The objective of this is to evaluate, in an empirical way, a model that presents three causal relationships between theoretical constructs in a group of 250 small and medium-sized enterprises (SMEs) in the state of Aguascalientes. The first one refers to whether organizational commitment has a positive and significant influence on the levels of learning orientation; the second is verifying if the organizational commitment has a positive and significant influence on the levels of inno­vation; and finally, inquiring if the learning orientation has a positive and significant impact on the level of innovation. The proposed model—which presents good adjustments—is validated through structural analysis using the confirmatory modeling strategy. Results are presented and they indicate that organi­zational commitment does have a positive and significant impact on the levels of learning orientation in the organization. Furthermore, learning orientation influences in a positive and significant way SMEs’ innovation in Aguascalientes. However, organizational commitment fails to show a significant positive influence on the innovation of SMEs in Aguascalientes. </p>
Impact of gender on the acceptance of electronic word-of-mouth (eWOM) information in Spain
Authors: Sánchez Torres Javier A. , Arroyo-Cañada Francisco-Javier , Solé-Moro Maria-Llüisa , Argila-Irurita Ana 
Published: January 2019

<p>The aim of this paper is to explore the differences between males and females in the acceptance of eWOM information. For this purpose, the Information Acceptance Model (IACM), which addresses the characteristics that are evaluated in the use and attitude towards the use of information and play a role in the purchase decision-making process, as demonstrated in the literature, has been used as a reference.<strong> </strong>An empirical model, which is expected to be validated from the information collected through an online questionnaire completed by 271 users of social networking sites in Spain, has been used. A structural equation model (SEM) is introduced to calculate the measurement structure of the variables and the relationships between them. This paper provides useful insights into the understanding of the differences in the behaviour of males and females regarding online eWOM, and therefore could imply differentiated online marketing and reputation management activities. </p><p> </p>
The spectrum of adverse drug reactions in a multidisciplinary kidney clinic
Authors: Al-Bader Shaima , Al-Bader Shaikha , El-Reshaid Kamel 
Published: January 2019

Introduction: Data on adverse drug-reactions (ADR) in the medical field are rare. Objective: To report on the pattern of such problem in a multidisciplinary kidney clinic Patients and Methods: Medical records of patients were reviewed retrospectively for such phenomenon in the past 6 years Results: A total of 4834 patients were included for analysis. The unit is responsible for a large proportion of patients with acute and chronic kidney diseases of diverse etiologies and multiple co-morbid conditions. Acute and maintenance dialysis as well as immunosuppressive treatment for idiopathic glomerulopathy and autoimmune systemic diseases were common practice. Results: A total of 70044 ADR were diagnosed in 4438 patients. Most patients were adults (39+14) and had median follow up of 38 months. Nearly half of the ADR were due to drug-side effects while idiosyncrasy accounted for 1.2%. The former is due to misuse/abuse of medications while the latter is due to genetic, co-morbid conditions or synergetic between 2 drugs or a drug and disease. Details of drugs ADR are outlined with their respective prevalence. Our study indicates the need for careful auditing of patient’s response during follow up to improve their drug-compliance.
Keywords: adverse drug reaction, allergy, medical clinic, kidney disease.
In-Vivo assessment of glucocorticoid loaded tea tree oil nanoemulsion gel
Authors: Alam Md. Sarfaraz , Saraswat Rohit , Sharma Pankaj , Ansari Md. Salahuddin 
Published: January 2019

Optimized formulations were subjected to various in vivo studies like anti-inflammatory activity, Nickel induced dermatitis, irritation study and Acute and repeated dose dermal toxicity studies. Clobetasol propionate (CP) has anti-inflammatory, immunomodulatory, and antiproliferative activity. The aim of the present work was to test the hypothesis that the addition CP in nanoemulsions would result in enhancement CP delivery and leading to better antipsoriatic activity. Nanoemulsions were prepared by aqueous phase titration method, using Tea Tree oil, Tween 20, Transcutol P, and distilled water as the oil phase, surfactant, co-surfactant and aqueous phase, respectively.We developed a topical O/W nanoemulsion in which drug is incorporated in disperse phase of oil and evaluated its efficacy against different types of in vivostudies. It was also found that the significantly increased their anti-inflammatory activity. It was reported that CP-loaded nanoemulsion significantly increased NTPDase (Nucleoside triphosphate diphosphohydrolases) activity in lymphocytes. This membrane protein is responsible for the hydrolysis of extracellular ATP (Adenosine triphosphate) which is responsible for cell proliferation, differentiation and inflammatory processes. In vivoirritation studies did not show any irritation in spite of having high amount of surfactant. Group treated with CP loaded nanoemulsion gel showed no evident toxicity even on repeated exposure. On the basis of above in vivo study we conclude that developed nanoemulsion is safe for human.
Keywords: Clobetasol propionate, In-vivo study, Nanoemulsion, Anti-inflammatory study, Toxicity study
Chitosan-based transdermal drug delivery systems to overcome skin barrier functions
Authors: Nair Syam S. 
Published: January 2019

Transdermal drug delivery system has been developed or being developed to vanquish the downsides associated with conventional strategies as it avoids first pass hepatic metabolism, improved patient compliances, easy termination of therapy, possibility of self-administration etc. The main challenge in designing transdermal patch is to overcome the low permeability of skin. Several strategies have been developed to overcome the barrier properties and to enhance the transportation of drug molecules across the skin. In the last decades numerous transdermal patches fabricated from polysaccharides have been reported. There has been a growing interest in using chitosan in transdermal formulations thanks to their biocompatibility, non-toxicity, film forming ability, non- skin irritancy etc. This article highlights the application of chitosan in the development of transdermal drug delivery systems such as microneedles, films etc.
Keywords: Transdermal drug delivery, first pass hepatic metabolism, low permeability, microneedles
Synthesis of different α, β- unsaturated oxazolone derivatives
Authors: Phalke Pallavi L 
Published: January 2019

Acetyl glycine were prepared from glycine acetic anhydride and then 2, 4-disubstituted Oxazol-5-one were prepared from acetyl glycine, substituted aldehydes, acetic anhydride, and sodium acetate as a catalyst. The formed product is evaluated and characterized by thin layer chromatography, infrared spectroscopy and melting point. The, β- unsaturated shows ability to react with various nucleophilic reagents for synthesis of new fused oxazole compounds.
Keywords: glycine, acetic anhydride, aldehyde Sodium acetate, Oxazolone, E. coli, Antibacterial Activity.
Transfersomes: a novel technique for transdermal drug delivery
Authors: Chaurasiya Priyanka , Ganju Eisha , Upmanyu Neeraj , Ray Sudhir Kumar , Jain Prabhat 
Published: January 2019

Novel drug delivery systems are now a days is creating a new interest in development of drug deliveries. Vesicular drug delivery system is also a part of these novel drug delivery systems. TDDS is the permeability of the skin, it is permeable to small molecules, lipophilic drug and highly impermeable to the macromolecules and hydrophilic drugs. Recent approaches have resulted in design of two vesicular carriers, ethosomes and ultra flexible lipid based elastic vesicles, transferosomes. Transferosomes have recently been introduced, which are capable of transdermal delivery of low as well as high molecular weight drugs. This offers several potential advantages over conventional routes like avoidance of first pass metabolism, predictable and extended duration of activity, minimizing undesirable side effects, utility of short half life drugs, improving physiological and pharmacological response and have been applied to increases the efficiency of the material transfer across the intact skin, by the use of penetration enhancers, iontophoresis, sonophoresis and use of colloidal carriers such as lipid vesicles (liposomes & proliposomes) and non-ionic surfactant vesicles (niosomes & proniosomes). It is suitable for controlled and targeted drug delivery and it can accommodate drug molecules with wide range of solubility. Due to its high deformability it gives better penetration of intact vesicles. They are biocompatible and biodegradable as they are made from natural phospholipids and have high entrapment efficiency. The preparation variables are depending upon the procedure involved for manufacturing of formulation and the preparation procedure was accordingly optimized and validated. Characterization of transferosomes can be done to know the vesicle size, morphology, drug content, entrapment efficiency, penetration ability, occlusion effect, surface charge, in vitro drug release, in vitro skin penetration etc., It increases stability of labile drugs and provides control release. Transferosomes thus differs from such more conventional vesicles primarily by its softer, more deformable, better adjustable artificial membrane.
Keywords: Novel Drug Delivery System, Biocompatible, Characterization, Transferosomes.
Physico-chemical Standardization of NPCF (Non-Pharmacopoeial Compound Formulation) Use in Diabetes mellitus
Authors: Ahmed Reesha , Khan Naeem Ahmad 
Published: January 2019

Background: Variety of reasons has been cited for the need for scientific evaluation and standardization of herbal drugs. Three methods, viz., activity-based standardization, determination of biologically active compound and standardization of herbal drugs on various physical, chemical and other parameters were found to be suitable and practically applicable. Phytochemical investigations along with biological screening to understand the therapeutic dynamics of medicinal plants etc. will help in developing quality parameters and help in the standardization and establish for authenticity and quality. Material and methods: Standardization was made on the basis of physicochemical and analytical parameters laid down by National Unani Pharmacopoeia Committee (Anonymous, 2007). Results: The parameters studied includes alcohol soluble content 15.34±0.48 water soluble content 18.27±0.38, successive extractive values viz. petroleum ether 7.60±0.05 , diethyl ether 1.24±0.02, chloroform 2.24± 0.04 , acetone 4.74±0.02, alcohol 8.51±0.06 , and aqueous 4.20±0.05, non- successive extractive values viz. petroleum ether 6.70±0.06, chloroform 7.70±0.06, alcohol16.15± 0.03 and aqueous 10.65±0.03, total ash 5.50±0.28 , acid insoluble ash 2.33±0.33, water soluble ash 1.16±0.16 , moisture content 7.30±0.12 , Bulk density 0.419±0.005 (pour density) and 0.74±0.01 (Tap density), pH values of 1% solution 4.89±0.01 and 10% solution 4.69±0.005. The qualitative analysis of various phytochemicals was estimated that revealed the presence of alkaloid, carbohydrate, flavonoids, protein, starch, phenols, tannin, sterols, amino acid and resin. The TLC profile of the extracts of non-pharmacopoeial Compound Formulation was also performed which confirms various biomolecules in it.. Conclusion: This study helps in determining the quality and purity of NPCF which is use in Diabetes mellitus.
Keywords: Standardization, Non-Pharmacopoeial Compound formulation, Physico-chemical study
Adverse Drug Reactions (ADR’S) monitoring at tertiary care Hospital
Authors: Prashanthi B. , Modi Hepsibha , Kalagara Dharmateja 
Published: January 2019

The observational and brief cross section study was conducted in the ADR monitoring centre, department of pharmacology, SVS MEDICAL HOSPITAL. The adverse drug reactions (ADR) reported by physician of dermatology department of SVSMH were collected and then causality, severity and preventability assessment was done. The results were presented as number and percentage. Total of 544 patients were observed with 15 suspected ADRs. The incidence of dermatological ADR was 3.78%. Maximum incidence of dermatological ADRs were observed with anti-inflammatory agents and immunosuppressive (33.30%) followed by antibiotic drugs (13.3%).Dermatological adverse drug reactions were a common occurrence and awareness about them was found to be essential for early detection and prevention. The healthcare system can promote the spontaneous reporting of dermatological ADR top Pharmacovigilance centre's for ensuring safe drug use and patient care. . Most of the reported ADRs were possible, definitely preventable and mild in nature. Our study suggests that there is a need of intensive monitoring for ADRs in tertiary care hospital for early detection and to ensure the patient safety.
Keywords: adverse drug reaction, casualty, severity, probability.
Rosmarinus officinalis L.: an update review of its phytochemistry and biological activity
Authors: Kompelly Akshay , Kompelly Swathi , Vasudha Bakshi , Narender Boggula 
Published: January 2019

Herbal medicine is one of the oldest valuable bestowals that were given to mankind. Many plants and herbs hold their prestigious position in the field of medicine. The worldwide interest in the use of medicinal plants has been growing, and its beneficial effects being rediscovered for the development of new drugs. Based on their vast ethnopharmacological applications, which inspired current research in drug discovery, natural products can provide new and important leads against various pharmacological targets. This work pioneers an extensive and an updated literature review on the current state of research on Rosmarinus officinalis L., elucidating which compounds and biological activities are the most relevant. According to these references, there has been an increasing interest in the therapeutic properties of this plant, regarding carnosic acid, carnosol, rosmarinic acid and the essential oil. The present manuscript provides an updated review upon the most reported activities on R. officinalis and its active constituents. This knowledge about the medicinal plants usage can also be extended to other fields like field of pharmacology. In view of the nature of the plant, more research work can be done on humans so that a drug with multifarious effects will be available in the future market.
Keywords: Rosmarinus officinalis, phytochemicals, carnosic acid, rosmarinic acid, neuroprotective activity, anti-diabetic activity.
Synthesis, characterization and antimitotic activity of N-benzyl piperidin 4-one oxime
Authors: Sundaresan K. , Thangavel M. , Tharini K. 
Published: January 2019

The aim of this study was to synthesize, characterization and antimitotic activity of N-Benzyl piperidin 4-one oxime derivative. The synthesized compound was characterized by IR, 13C and 1H NMR spectral studies. The synthesized compound was subjected to antimitotic studies of alliumcepa root meristamatic cells. The mitotic activity was observed in 3 different concentrations of N-Benzyl piperidin 4-one oxime. Our findings support the reported therapeutic use of this compound as a antimitotic or anticancer agent in the Indian system of medicine.
Keywords: N-Benzyl piperidin 4-one oxime, meristamatic cells, mitotic index.