bluuebunny/crossref_metadata_2025_split huggingface dataset:
The expression and function of galectins in skin physiology and pathology
Authors: Wu Nan‐Lin , Liu Fu‐Tong 
Published: February 2018

AbstractThe galectin family comprises β‐galactoside–binding proteins widely expressed in many organisms. There are at least 16 family members, which can be classified into three groups based on their carbohydrate‐recognition domains. Pleiotropic functions of different galectins in physiological and pathological processes through extracellular or intracellular actions have been revealed. In the skin, galectins are expressed in a variety of cells, including keratinocytes, melanocytes, fibroblasts, dendritic cells, lymphocytes, macrophages and endothelial cells. Expression of specific galectins is reported to affect cell status, such as activation or death, and regulate the interaction between different cell types or between cells and the extracellular matrix. In vitro cellular studies, in vivo animal studies and studies of human clinical material have revealed the pathophysiologic roles of galectins in the skin. The pathogenesis of diverse non‐malignant skin disorders, such as atopic dermatitis, psoriasis, contact dermatitis and wound healing, as well as skin cancers, such as melanoma, squamous cell carcinoma, basal cell carcinoma and cutaneous haematologic malignancy can be regulated by different galectins. Revelation of biological roles of galectins in skin may pave the way to future development of galectin‐based therapeutic strategies for skin diseases.
Depletion of keratin 8/18 modulates oncogenic potential by governing multiple signaling pathways
Authors: Tiwari Richa , Sahu Indrajit , Soni Bihari Lal , Sathe Gajanan J , Thapa Pankaj , Patel Pavan , Sinha Shruti , Vadivel Chella Krishna , Patel Shweta , Jamghare Sayli Nitin , Oak Swapnil , Thorat Rahul , Gowda Harsha , Vaidya Milind M. 
Published: February 2018

Keratin 8/18, the predominant keratin pair of simple epithelia, is often aberrantly expressed in various squamous cell carcinomas (SCCs) including skin SCC. Its aberrant expression is correlated with increased invasiveness and poor prognosis of the same, although the underlying mechanism is still unclear. A previous report from our laboratory has shown K8‐mediated regulation of α6β4 integrin signaling and thereby tumorigenic potential of oral SCC‐derived cells. Another study on transgenic mouse model has shown that during skin carcinogenesis, K8 favors conversion of papillomas toward malignancy. In order to understand the role of K8 and allied mechanism in skin SCC, K8 was stably knocked down in a skin epidermoid carcinoma‐derived A431 cells. K8 downregulation significantly reduced the tumorigenic potential of these cells. In agreement with our phenotypic data, differential quantitative proteomics followed by IPA analysis showed altered expression of many proteins associated with biological functions including ‘Cancer’, ‘Cellular movement’, ‘Cell death and survival’, and ‘Cellular morphology’. Some of these proteins were TMS1, MARCKSL1, RanBP1, 14‐3‐3γ, Rho‐GDI2, etc. Furthermore, to our surprise, there was a significant reduction in K17 protein stability upon loss of K8, probably due to its caspase‐mediated degradation. This was supported by altered TMS1‐NF‐κB signaling, leading to increased apoptotic sensitivity of A431 cells which in turn affected ‘Cell death and survival’. Moreover, MARCKSL1‐Paxillin1‐Rac axis was found to be deregulated bestowing a possible mechanism behind altered ‘Cellular movement’ pathway. Altogether our study unravels a much broader regulatory role of K8, governing multiple signaling pathways and consequently regulating oncogenic potential of skin SCC‐derived cells.DatabaseProteome Xchange Consortium via PRIDE database (dataset identifier PXD007206).
Prognostic impact of tumour–stroma ratio in early‐stage oral tongue cancers
Authors: Almangush Alhadi , Heikkinen Ilkka , Bakhti Nassira , Mäkinen Laura K , Kauppila Joonas H , Pukkila Matti , Hagström Jaana , Laranne Jussi , Soini Ylermi , Kowalski Luiz P , Grénman Reidar , Haglund Caj , Mäkitie Antti A , Coletta Ricardo D , Leivo Ilmo , Salo Tuula 
Published: February 2018

AimsOral tongue squamous cell carcinoma (OTSCC) has a relatively poor outcome, and there is a need to identify better prognostic factors. Recently, tumour–stroma ratio (TSR) has been associated with prognosis in several cancers. The aim of this multi‐institutional study was to evaluate the prognostic value of TSR from original haematoxylin and eosin (HE)‐stained tumour‐resection slides in a series of early‐stage (cT1‐2N0) OTSCC patients.Methods and resultsA TSR cutoff value of 50% was used to divide the patients into stroma‐rich (≥50%) and stroma‐poor (<50%) groups. The relationships between TSR and clinicopathological characteristics of 311 early‐stage OTSCC cases were analysed. The prognostic value of TSR in OTSCC was calculated separately and in combination with a previously published cancer cell budding and depth of invasion (BD) prognostic model. A total of 89 cases (28.6%) belonged to the stroma‐rich group. In a multivariate analysis, the stroma‐rich group had worse disease‐free survival, with a hazard ratio (HR) of 1.81 [95% confidence interval (CI) 1.17–2.79, P = 0.008], and higher cancer‐related mortality (HR 1.71, 95% CI 1.02–2.86, P = 0.03). The combination of the highest‐risk parameter scores of TSR and the BD model showed significant correlations with recurrence rate (HR 3.42, 95% CI 1.71–6.82, P = 0.004) and cancer‐related mortality (HR 11.63, 95% CI 3.83–35.31, P < 0.001).ConclusionsWe conclude that TSR is a simple histopathological feature that is useful for prognostication of early‐stage OTSCC, and suggest that TSR analyses in association with BD score could be included in routine clinical pathology reports for HE‐stained slides.
BETTER LATER THAN NEVER? AN EXPERIMENT ON BARGAINING UNDER ADVERSE SELECTION
Authors: Bochet Olivier , Siegenthaler Simon 
Published: February 2018

AbstractA central result in the literature on bargaining with asymmetric information is that the uninformed party (buyer) can screen the informed party (seller) over time. Screening eliminates trade failures that are otherwise common in the presence of adverse selection, but the downside of the bargaining institution is the cost associated with repeated offers and time frictions. This article reports an experimental test of these predictions. We find that rates of trade are substantially higher in the bargaining institution than in control treatments in which we remove the possibility to make repeated offers (take‐it‐or‐leave‐it offer) or the time frictions. However, we also observe a persistent overdelay before agreements are reached, that is, bargaining takes longer than theoretically predicted. This lowers efficiency below its predicted level and below the level observed in the take‐it‐or‐leave‐it offer institution. We identify possible channels for overdelay in the form of fairness preferences and loss aversion, concluding that there are important behavioral deviations from the standard model that are detrimental to the efficiency of bargaining under incomplete information.
The use of selected hydrocolloids to enhance cooking quality and hardness of zero‐salt noodles
Authors: Tan Hui‐Ling , Tan Thuan‐Chew , Easa Azhar Mat 
Published: February 2018

SummaryThe effects of table salt (TS) and hydrocolloids on water‐holding capacity, optimum cooking time, cooking qualities, pH and textural properties of noodles were investigated. TS, xanthan gum (XG), carrageenan (CRG), Arabic gum (AG) and locust bean gum (LBG) were added at 0.5%, 1.0%, 1.5% and 2.0% of flour weight. XG, CRG and LBG contributed to significantly (P < 0.05) higher water‐holding capacity of dough and firmer texture, but significantly (P < 0.05) lower cooking loss than zero‐salt noodles (ZSNs) and white‐salted noodles (WSNs). Hydrocolloids contributed in shorter optimum cooking time than ZSNs. Springiness of noodles was not significantly (P > 0.05) affected by increment of TS and hydrocolloids. TS1.5, ZSN‐XG1.5, ZSN‐XG2.0 and ZSN‐CRG1.5 had significantly (P < 0.05) higher cooking yield than ZSNs. The increment of TS and hydrocolloids had significantly (P < 0.05) increased the pH values of noodles. ZSN‐XG2.0, ZSN‐CRG1.5 and ZSN‐LBG1.5 may be useful to enhance ZSNs due to the better noodles qualities than ZSNs.
Comprehensive re‐evaluation of historical von Willebrand disease diagnosis in association with whole blood platelet aggregation and function
Authors: Nummi V. , Lassila R. , Joutsi‐Korhonen L. , Armstrong E. , Szanto T. 
Published: February 2018

AbstractIntroductionDiagnosis of von Willebrand disease (VWD) is challenging, particularly for type 1. The current diagnostic guidelines emphasize simultaneous bleeding symptoms and von Willebrand factor (VWF) levels of <30‐40 IU/dL. Historical diagnoses require updated evaluation. We assessed the accuracy of past VWD diagnoses in our comprehensive care center with the standardized bleeding score (BS) and central laboratory analysis, focusing on VWF‐dependent platelet functions in whole blood.MethodsOur study comprised 83 adults with prior VWD who were diagnosed a median of 20 years ago. We assessed BS, VWF antigen and activity (minimum of 3 measurements), FVIII, PFA‐100®, and platelet aggregation via Multiplate®. Genetic testing was targeted to types 3, 2N, 2B, and equivocal cases.ResultsAll 13/13 (100%) type 3 and 29/32 (90%) type 2, but only 10/38 (26%) of type 1 (overall 52/83 (63%)) patients met the current criteria for VWD. All confirmed cases had abnormal BS, impaired PFA‐100®, and decreased or absent ristocetin‐induced platelet aggregation (RIPA), except subtype 2B. VWF, FVIII, RIPA, and PFA correlated with BS including all study subjects. Ten of the 38 patients with previous type 1 had low VWF (35‐50 IU/dL) and variable VWF‐dependent platelet function. Altogether, 21/83 patients (25%) had repeatedly normal VWF:RCo (>50 IU/dL).Conclusionvon Willebrand disease is associated with impaired VWF‐dependent whole blood platelet functions that match traditional VWF measurements. We detected normal VWF in 25% of historically diagnosed patients, mainly type 1 patients, implying that there is a need to systematically re‐evaluate historical VWD diagnoses.
Distinguishing myelofibrosis from polycythemia vera and essential thrombocythemia: The utility of enumerating circulating stem cells with aberrant hMICL expression by flow cytometry
Authors: Herborg L. L. , Nederby L. , Hasselbalch H. C. , Aggerholm A. , Roug A. S. 
Published: February 2018

AbstractIntroductionDiagnosing BCR‐ABL negative myeloproliferative neoplasms (MPN) may be challenging due to overlapping features and lack of robust discriminatory parameters, especially between essential thrombocythemia (ET) and prefibrotic myelofibrosis (MF). Circulating immature hematopoietic cells are variably present in polycythemia vera (PV), ET, and MF. The C‐type lectin hMICL is aberrantly expressed on hematopoietic stem cells in the majority of acute myeloid leukemia patients. However, the hMICL expression in MPN, having varying propensity of leukemic transformation, is unsettled. We hypothesized that enumeration of immature cells by flow cytometry (FCM) could be a discriminatory tool in MPN diagnostics.MethodsBy FCM, we quantified circulating stem cells with aberrant hMICL expression in 39 MPN patients, 10 age‐matched controls, and in leukapheresis products from 10 patients with lymphoproliferative neoplasms. The utility of the FCM assay for discriminating MPN entities was evaluated by applying ROC curve analysis.ResultsWhile hMICL was absent in control samples, MF patients had significantly more hMICL+ stem cells (median 15.2%) than PV and ET (0.0%, P = .001 and 0.0%, P = .002, respectively). By ROC curve analysis, the presence of hMICL+ stem cells (>0 cells) in peripheral blood reliably discriminates MF from ET and PV with a sensitivity of 80% and a specificity of 97%.ConclusionEnumeration of circulating hMICL+ stem cells by FCM can discriminate between MPN phenotypes and holds potential for monitoring disease evolution.
The effect of reminiscence therapy on quality of life, attitudes to ageing, and depressive symptoms in institutionalized elderly adults with cognitive impairment: A quasi‐experimental study
Authors: Siverová Jarmila , Bužgová Radka 
Published: February 2018

AbstractThe aim of this study was to analyse the effect of group narrative reminiscence therapy on cognition, quality of life, attitudes towards ageing, and depressive symptoms in a group of older adults with cognitive impairment in institutional care. A quasi‐experimental pretest/post‐test control group design was employed. Interventions involving reminiscence therapy with a narrative approach were included in the care plan and implemented in groups of between five and ten respondents once a week for 8 weeks (total 59 participants). The members of the control group (n = 57) received standard care. A study questionnaire was designed to measure demographic characteristics, quality of life (WOHQOL‐BREF, WHOQOL‐OLD), depressive symptoms (GDS), cognition (MMSE), and attitudes towards ageing (AAQ). Reminiscence therapy positively affected older adults’ quality of life (mostly the areas of mental health and social participation), and also their attitudes to ageing and old age. It reduced symptoms of depression, but had no discernible effect on cognitive function. Reminiscence therapy can positively affect selected aspects of quality of life, attitudes towards old age, and symptoms of depression in the elderly in long‐term healthcare facilities. Group reminiscence therapy can be used as a nursing intervention.
Thermal and optical properties of La2O3–Ga2O3– (Nb2O5 or Ta2O5) ternary glasses
Authors: Yoshimoto Kohei , Masuno Atsunobu , Ueda Motoi , Inoue Hiroyuki , Yamamoto Hiroshi , Kawashima Tatsunori 
Published: February 2018

AbstractLa2O3–Ga2O3–M2O5 (M = Nb or Ta) ternary glasses were fabricated using an aerodynamic levitation technique, and their glass‐forming regions and thermal and optical properties were investigated. Incorporation of adequate amounts of Nb2O5 and Ta2O5 drastically improved the thermal stabilities of the glasses against crystallization. Optical transmittance measurements revealed that all the glasses were transparent over a wide wavelength range from the ultraviolet to the mid‐infrared. The refractive indices of the glasses increased and the Abbe number decreased upon substituting Ga2O3 with Nb2O5, and the decrease in the Abbe number was significantly suppressed when Ta2O5 was incorporated into the glass. As a result, excellent compatibility between high refractive index and lower wavelength dispersion was realized in La2O3–Ga2O3–Ta2O5 glasses. Analysis based on the single‐oscillator Drude–Voigt model provided more systematical information and revealed that this compatibility was due to an increase in the electron density of the glass.
Intergranular amorphous films formed by DC electric field in pure zirconia
Authors: Morisaki Nobuhiro , Yoshida Hidehiro , Kobayashi Tetsuro , Tokunaga Tomoharu , Yamamoto Takahisa 
Published: February 2018

AbstractIt is difficult to obtain pure ZrO2 sintered compacts with a bulk style at room temperature because a large volumetric expansion from tetragonal to monoclinic phase (t/m) transformation occurs at around 1000°C, which is lower than the sintering temperature. In contrast, pure monoclinic ZrO2 can be consolidated without shattering using flash‐sintering at 1350°C for 5 minutes under an applied DC electric field of 175 V/cm. High‐resolution transmission electron microscopy and electron energy loss spectroscopy have revealed that amorphous films are formed along grain boundaries after flash‐sintering at 1350°C for 5 minutes. Monoclinic ZrO2 flash‐sintered compact including the amorphous films are able to survive without shattering through the t/m transformation, as the amorphous films partially absorb the large volumetric expansion arising from the t/m transformation. The formation of the amorphous films results from the severe reducing condition due to the applied DC electric fields during flash‐sintering.
α‐Alumina nanospheres from nano‐dispersed boehmite synthesized by a wet chemical route
Authors: Petrakli Fotini , Arkas Michalis , Tsetsekou Athena 
Published: February 2018

AbstractIn this work, stable aqueous suspensions of nano‐boehmite were developed through a hybrid wet‐chemical route that uses hyperbranched dendritic poly(ethylene)imine (PEI) as template material for boehmite formation aiming at the development of a deagglomerated α‐alumina nanopowder after calcination. The method involves firstly the interaction between the Al precursor and PEI followed by the hydrolysis and polycondensation reactions. The study was aiming to investigate the effect of solids content and pH during reactions on both the stability of the final suspension and the morphology of the resulting nanocrystals. For this purpose, the suspensions were evaluated through viscosity measurements, zeta potential analyses, FT‐IR, DLS and sedimentation studies, whereas after the proper centrifugation, drying, and calcination steps, the as‐received nanocrystals were evaluated through SEM, TEM and XRD studies. In addition, the boehmite nanopowder was studied using Thermogravimetric and Differential Thermal Analysis, whereas its sinterability was evaluated by dilatometric measurements. The investigation showed that the conditions employed affect greatly both the morphology of nanocrystals as well as the dispersion and the stability of the suspensions. The boehmite suspension with the optimum dispersion and stability can lead, after calcination at 1050°C, to a fine deagglomerated α‐alumina nanopowder with a mean size at about 10 nm.
Energetics of bulk lutetium‐doped Ce1−xLuxO2−x/2 compounds
Authors: Yavo Nimrod , Sharma Geetu , Kimmel Giora , Lubomirsky Igor , Navrotsky Alexandra , Yeheskel Ori 
Published: February 2018

AbstractThe dissolution enthalpy, ΔHDS, and the formation enthalpy, ΔHf,ox, of bulk lutetium‐doped cerium oxide (LuDC) were studied at 701°C in molten sodium molybdate. For the composition range of Ce1−XLuXO2−X/2, studied 0 ≤ X ≤ 0.3, the ΔHDS decreases linearly and smoothly with lutetium content according to ΔHDS, kJ/mol = 73.5(1.0)−165.1(5.5)·x). The enthalpy of formation, ΔHf,ox, becomes more exothermic linearly with lutetium content. No anomaly in ΔHf,ox is observed at low Lu2O3 concentration as reported previously for several other rare‐earth‐doped ceria systems, suggesting possible differences in clustering and microstructure, which may also be related to difference in processing conditions.
Preparation of γ‐aluminum oxynitride phosphor with Eu doping by direct nitridation in ammonia and postannealing
Authors: Zhang Li , Luo Huan , Zhou Linan , Liu Qian , Li Junfeng , Zhang Wentao 
Published: February 2018

Abstractγ‐aluminum oxynitride (γ‐AlON) with spinel structure has attracted much attention for structural and functional application. γ‐AlON powders were successfully prepared by direct nitridation method of Al/Al(OH)3 starting mixture in ammonia and then calcined at high temperature. XRD, SEM, TEM, EDX, and photoluminescence were conducted to investigate the detail procedure and the optical properties of AlON: xEu phosphors. Nitrogen was introduced by the nitridation of metallic aluminum, appropriate Al amount and nitridation condition was necessary to obtain phase pure γ‐AlON. The as‐prepared AlON powders exhibited multifaceted grain morphology with fine particle size (1‐5 μm). Eu2O3 activator was reduced and transformed to EuAl12O19 by reaction with alumina, which remained in the product when x > 0.25%. Under 331 nm excitation, AlON: xEu phosphors exhibited emission bands of 475 and 410 nm. 475 nm band reached a plateau at x = 0.25% due to the solubility of Eu2+ ion in AlON, whereas 410 nm band showed a linear increase in intensity with Eu2+ doping amount, which was believed to be the contribution of EuAl12O19. The present approach combination of direct nitridation in ammonia and postcalcination process showed potential application for AlON ceramic and AlON phosphors.
Optical thermometry of Sm3+ on laser‐induced local heating for precipitation of PbS quantum dots in glasses
Authors: So Byoungjin , Heo Jong 
Published: February 2018

AbstractFluorescence intensity ratios (FIRs) of the 640 nm and 602 nm emissions from Sm3+ were recorded at various temperatures T to identify the temperature increases ΔT associated with laser‐induced local heating of Ag nanoparticles. The FIRs increased as intensities of the excitation beam from a 532‐nm continuous‐wave laser increased. Estimated T of the irradiated region increased to as high as 586°C when at laser irradiation of 1.5 W on the surface containing Ag nanoparticles. Local heating due to the surface plasmon resonance of Ag nanoparticles is a main reason for the ΔT that eventually leads to precipitation of PbS quantum dots in glasses.
Delay aversion in attention deficit/hyperactivity disorder is mediated by amygdala and prefrontal cortex hyper‐activation
Authors: Van Dessel Jeroen , Sonuga‐Barke Edmund , Mies Gabry , Lemiere Jurgen , Van der Oord Saskia , Morsink Sarah , Danckaerts Marina 
Published: February 2018

BackgroundExperimental research supports delay aversion as a motivational feature of attention deficit/hyperactivity disorder (ADHD). To investigate the neurobiology of delay aversion in ADHD, this study examined whether adolescents with ADHD display an unusually strong activation in affective brain regions in response to cues predicting forthcoming delay and whether these effects are (a) delay‐dose dependent and (b) statistically mediate the association between ADHD and self‐reported delay aversion.MethodsTwenty‐nine right‐handed male adolescents with combined type ADHD and 32 typically developing controls (ages 10–18 years) performed a reaction time task in an MRI scanner. Pretarget cues indicated delay‐related response consequences. One indicated that delay would follow the response irrespective of response speed (CERTAIN DELAY), a second that delay would only follow if the response was too slow (CONDITIONAL DELAY), and a third that no delay would follow the response whatever its speed (NO DELAY). Delay levels were 2, 6, or 14 s. Participants also rated their own delay aversion in everyday life.ResultsIndividuals with ADHD rated themselves as more delay averse than controls. Significantly greater activation to CERTAIN DELAY cues relative to NO DELAY cues was found in participants with ADHD compared to controls (bilaterally) in amygdala, anterior insula, temporal pole, dorsolateral prefrontal cortex (DLPFC), and ventromedial prefrontal cortex. Amygdala and DLPFC activation strength were strongly and delay‐dose dependently correlated with delay aversion ratings, and statistically mediated the relationship between ADHD status and delay aversion.ConclusionsWhen presented with cues predicting impending delay, adolescents with ADHD, relative to controls, displayed a delay‐related increase in activation in amygdala and DLPFC, regions known to be implicated in the processing of aversive events. Future studies should examine the specificity of these effects to delay aversion compared to aversive events in general.