bluuebunny/crossref_metadata_2025_split huggingface dataset:
Morphological differences between phyllosoma larvae from the western–central and eastern Pacific populations of the pronghorn spiny lobster Panulirus penicillatus
Authors: Matsuda Hirokazu , Sakai Mitsuo , Yanagimoto Takashi , Chow Seinen 
Published: June 2019

AbstractThe pronghorn spiny lobster Panulirus penicillatus is known to have the widest distribution among palinurid lobster species, occurring in tropical and sub-tropical areas of the Indo-Pacific Ocean. In the Pacific Ocean, mitochondrial DNA analyses have revealed that the western–central and eastern populations are genetically isolated. We performed morphological investigations on mid- to late-stage phyllosoma larvae collected in these two areas. The larvae of the western–central population had a significantly narrower cephalic shield, shorter abdomen, and longer eyestalk than those of the eastern population. Additionally, for larvae larger than about 25-mm body length, the widest position of the cephalic shield in the western–central population was located closer to the middle of the median line of the cephalic shield than that in the eastern population. The ratio of width to length of cephalic shield and the ratio of cephalic shield width to thorax width are key traits for distinguishing between the larvae of the two populations.
Differentiation of Urine-Derived Induced Pluripotent Stem Cells to Neuron, Astrocyte and Microvascular Endothelial Cells from a Diabetic Patient
Authors: Liu Wan , Zhang Ping , Tan Jing , Lin Yongzhong 
Published: June 2019

AbstractBackgroundComplications of central nervous system (CNS) in type 2 diabetes mellitus (T2DM) often lead to cognitive impairment and seriously affect the quality of life. However, there is no individualized disease model. Urinary epithelial cells (UECs) can be an ideal source for generating human induced pluripotent stem cells (hiPSCs) and progenitors, as they are easily accessible, non-invasive and universally available. Therefore, we intended to differentiate urine-derived hiPSCs into neuron (N), astrocyte (A) and microvascular endothelial cells (E) from a T2DM patient for future study its pathogenesis and precision medical treatment.Methods and ResultshiPSCs was successfully induced from UECs using integration free Sendai virus technology in a totally noninvasive manner. It had a normal karyotype (46, XY) and were proved to be pluripotent by immunofluorescence staining, alkaline phosphatase staining, karyotyping, teratoma experiments and methylated analysis. N, A and E were successfully induced and displayed typical morphological characteristics.ConclusionsThis study indicates that N, A, E can be generated from urine-derived hiPSCs. Then we intend to create a new disease model in vitro to simulate the cerebral microenvironment of DM which will provide new methods for further investigate the disease-specific mechanisms.
Uncovering thousands of new HLA antigens and phosphopeptides with deep learning-based sequence-mask-search de novo peptide sequencing framework
Authors: Karunratanakul Korrawe , Tang Hsin-Yao , Speicher David W. , Chuangsuwanich Ekapol , Sriswasdi Sira 
Published: June 2019

ABSTRACTTypical analyses of mass spectrometry data only identify amino acid sequences that exist in reference databases. This restricts the possibility of discovering new peptides such as those that contain uncharacterized mutations or originate from unexpected processing of RNAs and proteins. De novo peptide sequencing approaches address this limitation but often suffer from low accuracy and require extensive validation by experts. Here, we develop SMSNet, a deep learning-based hybrid de novo peptide sequencing framework that achieves >95% amino acid accuracy while retaining good identification coverage. Applications of SMSNet on landmark proteomics and peptideomics studies reveal over 10,000 previously uncharacterized HLA antigens and phosphopeptides and in conjunction with database-search methods, expand the coverage of peptide identification by almost 30%. The power to accurately identify new peptides of SMSNet would make it an invaluable tool for any future proteomics and peptidomics studies – especially cancer neoantigen discovery and proteome characterization of non-model organisms.
Accurate detection of non-proliferative diabetic retinopathy in optical coherence tomography images using convolutional neural networks
Authors: Ghazal Mohammed , Ali Samr , Mahmoud Ali , Shalaby Ahmed , El-Baz Ayman 
Published: June 2019

AbstractDiabetic retinopathy (DR) is a disease that forms as a complication of diabetes, It is particularly dangerous since it often goes unnoticed and can lead to blindness if not detected early. Despite the clear importance and urgency of such an illness, there is no precise system for the early detection of DR so far. Fortunately, such system could be achieved using deep learning including convolutional neural networks (CNNs), which gained momentum in the field of medical imaging due to its capability of being effectively integrated into various systems in a manner that significantly improves the performance. This paper proposes a computer aided diagnostic (CAD) system for the early detection of non-proliferative DR (NPDR) using CNNs. The proposed system is developed for the optical coherence tomography (OCT) imaging modality. Throughout this paper, all aspects of deployment of the proposed system are studied starting from the preprocessing stage required to extract input data to train the CNN without resizing the image, to the use of transfer learning principals and how best to combine features in order to optimize performance. A novel patch extraction framework for preprocessing is presented, followed by fovea detection algorithm, in addition to investigating the various CNN parameters for optimal deployment. Optimum CNN parameters and promising results are achieved. To the best of our knowledge, this is the first CNN-based DR early detection CAD system for OCT images. It achieves a promising accuracy of 94% with transfer learning.
Socioeconomic Differentials in Hypertension based on JNC7 and ACC/AHA 2017 Guidelines Mediated by Body Mass Index: Evidence from Nepal Demographic and Health Survey
Authors: Rana Juwel , Ahmmad Zobayer , Sen Kanchan Kumar , Bista Sanjeev , Islam Rakibul M 
Published: June 2019

AbstractBackgroundUnlike developed countries; higher socioeconomic status (SES, education, and wealth) is associated with hypertension in low and middle-income countries (LMICs) with limited evidence. We examined the associations between SES and hypertension in Nepal and the extent to which these associations vary by sex and urbanity. The body mass index (BMI) was examined as a secondary outcome and assessed as a potential mediator.Materials and methodsWe analyzed the latest Nepal Demographic and Health Survey data (N=13,436) collected between June 2016 and January 2017, using a multistage stratified sampling technique. Participants aged 15 years or older from selected households were interviewed with an overall response rate of 97%. Main outcomes were hypertension and normal blood pressure defined by the widely used Seventh Report of the Joint National Committee (JNC 7), and the American College of Cardiology/American Heart Association (ACC/AHA) 2017.ResultsThe prevalence of hypertension was higher in Nepalese men than women. The likelihood of having hypertension was more than double for individuals in the highest versus lowest wealth quintiles [men: OR 2.13, 95% CI 1.60-2.85); women: OR 2.54, 95% CI 2.00- 3.24] and for individuals with the higher education versus no education [men: OR 2.38, 95% CI 1.75-3.23; women: OR 1.63, 95% CI 1.18-2.25]. The associations between SES and hypertension were different by sex and urbanity. These associations were mediated by BMI.ConclusionsHigher SES was positively associated with the higher likelihood of having hypertension in Nepal according to both JNC 7 and ACC/AHA 2017 guidelines. These associations were mediated by BMI, which may help to explain broader socioeconomic differentials in CVD and related risk factors, particularly in terms of education and wealth. Our study suggests that the mediating factor of BMI should be tackled to diminish the risk of CVD in people with higher SES in LMICs.
Multi-objective optimisation of material properties and strut geometry for poly(L-lactic acid) coronary stents using response surface methodology
Authors: Blair R.W. , Dunne N.J. , Lennon A.B. , Menary G.H. 
Published: June 2019

AbstractCoronary stents for treating atherosclerosis are traditionally manufactured from metallic alloys. However, metal stents permanently reside in the body and may trigger undesirable immunological responses. Bioresorbable polymer stents can provide a temporary scaffold that resorbs once the artery heals but are mechanically inferior, requiring thicker struts for equivalent radial support, which may increase thrombosis risk. This study addresses the challenge of designing mechanically effective but sufficiently thin poly(L-lactic acid) stents through a computational approach that optimises material properties and stent geometry. Forty parametric stent designs were generated: cross-sectional area (post-dilation), foreshortening, stent-to-artery ratio and radial collapse pressure were evaluated computationally using finite element analysis. Response surface methodology was used to identify performance trade-offs by formulating relationships between design parameters and response variables. Multi-objective optimisation was used to identify suitable stent designs from approximated Pareto fronts and an optimal design is proposed that offers comparable performance to designs in clinical practice. In summary, a computational framework has been developed that has potential application in the design of high stiffness, thin strut polymeric stents that contend with the performance of their metallic counterparts.
Health care seeking behavior and associated factor among mothers/caregivers of under-five children with acute diarrhea in Dangila zuria Woreda, North west Ethiopia
Authors: Nega Biresaw , Bogale Kassawmar Angaw , Nigussie Zelalem Mehari 
Published: June 2019

ABSTRACTIntroductionHealth care seeking interventions can reduce child mortality from easily treatable diseases, however, significant numbers of children die by diarrheal disease due to delays in seeking care in Ethiopia. Thus, the aim of this study was assessed health care seeking behavior and associated factors among mothers/caregivers of under-five children with acute diarrhea in Dangila zuria Woreda, North West Ethiopia, 2018.MethodCommunity-based cross-sectional study design was conducted using structured questionnaires. Data were entered Epi Data Version 3.1 and analyzed using SPSS Version 23. Descriptive statistics were used to examine patterns of health care seeking behavior and multivariable logistic regression analysis was applied to identify factors associated with health care seeking behaviorResultThe magnitude of health care seeking behavior of mothers/caregivers of under-five children with acute diarrhea was found to be 77.7%. Primary level of education [AOR = 2.0; 95% (CI (1.1-3.9)], sex of child (male) [AOR = 1.7; 95% (CI 1.1-2.6)], availability of health facilities within 60 minutes walking distance [AOR = 2.4; 95 %(CI 1.4-4.1)], severity of illness [AOR=7.5; 95% (CI 3.7-15.2)], two or more under-five children in the family [AOR=0.6;95% (CI 0.4-0.9)], perceived cause of acute diarrhea, (new teeth [AOR =0.3;95% (CI 0.2-0.5)] were significantly associated with health care seeking behavior of mothers/caregivers.ConclusionIncreasing the proximity of health facilities and educate mothers/caregivers about the importance of health care seeking behavior and cause of acute diarrhea were recommended to improve health care seeking behavior.
K3Eu5(PO4)6: hydrothermal synthesis, crystal structure and photoluminescence properties
Authors: Xue Ya-Li , Zhang Ai-Yun , Han Xiao-Yang , Cui Xiao-Qi , Deng Ling , Zhou Yi-Xiang , Yu Ya-Ping , Zhao Dan 
Published: June 2019

An anhydrous orthophosphate, K3Eu5(PO4)6 (tripotassium pentaeuropium hexaphosphate), has been prepared by a high-temperature solid-state reaction combined with hydrothermal synthesis, and its crystal structure was determined by single-crystal X-ray diffraction analysis (SC-XRD). The results show that the compound crystallizes in the monoclinic space group C2/c and the structure features a three-dimensional framework of [Eu5(PO4)6]∞, with the tunnel filled by K+ ions. The IR spectrum, UV–Vis spectrum and luminescence properties of polycrystalline samples of K3Eu5(PO4)6, annealed at temperatures of 650, 700, 750, 800 and 850 °C, were investigated. Although with a full Eu3+ concentration (9.96 × 1021 ions cm−3), the self-activated phosphor K3Eu5(PO4)6 shows s strong luminescence emission intensity with a quantum yield of 37%. Under near-UV light excitation (393 nm), the series of samples shows the characteristic emissions of Eu3+ ions in the visible region from 575 to 715 nm. The sample sintered at 800 °C gives the strongest emission and its lifetime sintered at 800 °C (1.88 ms) is also the longest of all.
Exploring the female autism phenotype of repetitive behaviours and restricted interests (RBRIs): a systematic PRISMA review
Authors: Allely Clare 
Published: June 2019

PurposeThe purpose of this paper is to address the need for increased understanding, awareness and recognition of the autism female phenotype in terms of repetitive behaviours and restricted interests (RBRIs).Design/methodology/approachA systematic PRISMA review was conducted. The main aim of the present systematic review is to identify studies which have investigated RBRIs in females with autism spectrum disorder (ASD) or the differences in RBRIs between males and females with ASD.FindingsIn sum, 19 relevant articles were identified: 5 studies found no significant evidence to support the notion of sex differences in RRBIs in ASD; 1 study did not report any differences in RRBIs between males and females with ASD; 12 studies found evidence that males with ASD had significantly more RRBIs compared to females with ASD; and, lastly, 1 study found that girls with ASD have features of RRBIs which are exhibited more compared to boys with ASD.Research limitations/implicationsThere is a real lack of in-depth knowledge and understanding of the female phenotype of ASD, and such lack of knowledge has a detrimental impact on the identification of autistic females and a lack of identification can have negative consequence. This is important to address in future research as it is well established that the earlier the diagnosis, the better the outcomes, due to the timely access to appropriate interventions.Practical implicationsThe RBRIs exhibited in autistic females are not sufficiently captured by most currently diagnostic instruments. Clinicians are less likely to identify the RBRIs in females as they tend not to be the typical repetitive behaviours commonly associated with ASD. It has been recommended that clinicians consider “females as a whole” in terms of their clinical presentation and look for any indication of RBRIs, even repetitive interests which appear clinically innocuous.Originality/valueThere is relatively little research investigating RBRIs in autistic women and girls. There is a real need to highlight the importance of understanding and recognising how RBRIs can differ between males and females with ASD.
The logic of four decades of economic reform and major breakthroughs in political economy in China
Authors: Hong Yinxing 
Published: June 2019

Purpose
In the process of reform, although every landmark theoretical breakthrough is marked by the speech of the highest leadership of the Communist Party of China (CPC) or the decision of the CPC National Congress, each breakthrough is attributable to the theoretical contribution made by the academia of political economy. Notably, these theoretical breakthroughs invariably embrace innovations in the discourse system of political economy. The paper aims to discuss this issue.

Design/methodology/approach
The innovations and breakthroughs thereof have led to the political economy of socialism with Chinese characteristics.

Findings
The success of China’s economy highlights the superiority of the socialist economic system and development path with Chinese characteristics.

Originality/value
These major breakthroughs are accompanied by breakthroughs in relevant theories, which constitute a synthesis of a series of major theoretical innovations in political economics.
A conceptual model and empirical assessment of HR security risk management
Authors: Kumah Peace , Yaokumah Winfred , Okai Eric Saviour Aryee 
Published: June 2019

Purpose
This study aims to develop a conceptual model and assess the extent to which pre-, during- and post-employment HR security controls are applied in organizations to manage information security risks.

Design/methodology/approach
The conceptual model is developed based on the agency theory and the review of theoretical, empirical and practitioner literature. Following, empirical data are collected through a survey from 134 IT professionals, internal audit personnel and HR managers working within five major industry sectors in a developing country to test the organizational differences in pre-, during- and post-employment HR security measures.

Findings
Using analysis of variance, the findings reveal significant differences among the organizations. Financial institutions perform better in employee background checks, terms and conditions of employment, management responsibilities, security education, training and awareness and disciplinary process. Conversely, healthcare institutions outperform other organizations in post-employment security management. The government public institutions perform the worst among all the organizations.

Originality/value
An integration of a conceptual model with HR security controls is an area that is under-researched and under-reported in information security and human resource management literature. Accordingly, this research on HR security management contributes to reducing such a gap and adds to the existing HR security risk management literature. It, thereby, provides an opportunity for researchers to conduct comparative studies between developed and developing nations or to benchmark a specific organization’s HR security management.
Retail services efficiency: impact of country-specific factors
Authors: Cruz Roche Ignacio , Romero Jaime , Sellers-Rubio Ricardo 
Published: June 2019

PurposeEfficiency in retailing companies is mandatory for survival. Literature acknowledges external factors impact on efficiency. However, this impact remains understudied, as previous research typically focuses on managerial decisions. The purpose of this paper is to partially fill this gap by exploring the influence of external factors on retailers’ efficiency.Design/methodology/approachThis research simultaneously measures retail efficiency and evaluates the impact of six potential drivers by applying bootstrap techniques in a sample of 25 European Union countries during the period 2006–2015.FindingsThe efficiency of the retail system in the countries under analysis evolves at different paces during the observation period. This evolution can be explained by country population density, average store size within countries, foreign trade ratio, concentration, economic freedom and percentage of urban population.Research limitations/implicationsThis research does not account for supply and demand restrictions that might affect retailers’ efficiency, as well as other variables that influence their production process.Practical implicationsThis paper might help retail managers to comprehend and manage their companies’ efficiency. Furthermore, it provides clues to evaluate market attractiveness in retailers’ international expansion strategies.Social implicationsPolicy makers can facilitate retailers’ efficiency through regulations on external variables that influence retailers’ performance, namely economic freedom and foreign trade ratio.Originality/valueFor the first time, this study analyses the impact of external factors on retail services efficiency across countries.
Overcoming “over-tourism”: the closure of Maya Bay
Authors: Koh Edward , Fakfare Pipatpong 
Published: June 2019

Purpose
The temporary closure of Maya Bay – located at Phi Phi Le Island in Thailand’s Krabi province – was an executive decision made to overcome problems of “over-tourism” and degradation of the marine ecosystems. The purpose of this paper is to assess the process of stakeholder engagement by the Thai authorities before they arrived at decisions on the closure of Maya Bay.

Design/methodology/approach
A multi-method qualitative research through in-depth interviews and netnography was designed to examine opinions of participants within the context of investigation.

Findings
The key findings revolve around the central research question of “how are stakeholders managed and consulted to overcome ‘over-tourism’ in Maya Bay?”. The research question can be sub-divided into three parts – the identification of “over-tourism,” the process of engaging and consulting with stakeholders on solutions to deal with “over-tourism,” and the final decision on selected approaches to overcome “over-tourism.”

Originality/value
The researchers draw upon the views from the five groups of stakeholders to propose recommendations on tackling “over-tourism” issues that local governments and destination management agencies might face. A business, residents, authorities, visitors and environmentalists (BRAVE) stakeholders framework is proposed by integrating five main stakeholder categories – businesses (B), residents (R), authorities (A), visitors (V) and environmentalists (E). This “BRAVE” stakeholders model is then used to assess the various stakeholders’ positions on the issue of “over-tourism” in Maya Bay, including a cost-benefit analysis in an “over-tourism” situation. Particular attention is placed on how different stakeholders work together and converge on a decision accepted by all.