bluuebunny/crossref_metadata_2025_split huggingface dataset:
Proteomics Analysis of CA1 Region of the Hippocampus in Pre-, Progression and Pathological Stages in a Mouse Model of the Alzheimer’s Disease
Authors: Gurel Busra , Cansev Mehmet , Koc Cansu , Ocalan Busra , Cakir Aysen , Aydin Sami , Kahveci Nevzat , Ulus Ismail Hakki , Sahin Betul , Basar Merve Karayel , Baykal Ahmet Tarik 
Published: July 2019

Background:
CA1 subregion of the hippocampal formation is one of the primarily affected
structures in AD, yet not much is known about proteome alterations in the extracellular milieu of this
region.

Objective:
In this study, we aimed to identify the protein expression alterations throughout the
pre-pathological, progression and pathological stages of AD mouse model.

Method:
The CA1 region perfusates were collected by in-vivo intracerebral push-pull perfusion from
transgenic 5XFAD mice and their non-transgenic littermates at 3, 6 and 12 wereβmonths of age. Morris
water maze test and immunohistochemistry staining of A performed to determine the stages of the disease
in this mouse model. The protein expression differences were analyzed by label-free shotgun proteomics
analysis.

Results:
A total of 251, 213 and 238 proteins were identified in samples obtained from CA1 regions of
mice at 3, 6 and 12 months of age, respectively. Of these, 68, 41 and 33 proteins showed statistical significance.
Pathway analysis based on the unique and common proteins within the groups revealed that
several pathways are dysregulated during different stages of AD. The alterations in glucose and lipid
metabolisms respectively in pre-pathologic and progression stages of the disease, lead to imbalances in
ROS production via diminished SOD level and impairment of neuronal integrity.

Conclusion:
We conclude that CA1 region-specific proteomic analysis of hippocampal degeneration
may be useful in identifying the earliest as well as progressional changes that are associated with Alzheimer’s
disease.
Biomechanical Forces and Atherosclerosis: From Mechanism to Diagnosis and Treatment
Authors: Genkel Vadim V. , Kuznetcova Alla S. , Shaposhnik Igor I. 
Published: July 2019

:
The article provides an overview of current views on the role of biomechanical forces in
the pathogenesis of atherosclerosis. The importance of biomechanical forces in maintaining vascular
homeostasis is considered. We provide descriptions of mechanosensing and mechanotransduction.
The roles of wall shear stress and circumferential wall stress in the initiation, progression and
destabilization of atherosclerotic plaque are described. The data on the possibilities of assessing
biomechanical factors in clinical practice and the clinical significance of this approach are presented.
The article concludes with a discussion on current therapeutic approaches based on the
modulation of biomechanical forces.
Peran Kepercayaan Memediasi Hubungan Promosi Politik dan Citra Kandidat Terhadap Keputusan Pemilihan Kepala Desa
Authors: Liantifa Melifia 
Published: July 2019

<p><em>The purpose of the research was to investigate the intervening effect of trust on the relationship between political promotian and candidate image and selection decision of The Rural Districts Major in Siulak Kecil Hilir. The research of sample was all constituents who used voting rights in the Period of 2016 which accounted for 263 constituents using simple random sampling method. Data was colected through questionnaire with Likert’s scale which analysis using deskriptive qualitative and quantitative as test of validity and reliability, coefisien of determination, hypothesis testing performs hierarchical regression analysis by processing the data using SPSS 19.0 for windows. The result of analysis found that: a) political promotian and candidate image significantly influeced constituens trust and selection decision of The Rural Districts Major in Siulak Kecil Hilir. b) Constituens trust significantly influeced selection decision. While, c) Constituens trust was found as intervening variable between political promotian and candidate image and selection decision of The Rural Districts Major in Siulak Kecil Hilir. The research findings provide practical contribution especially for candidates The Rural Districts Major to future to consider constituents trust and enhancing both political promotion and candidate image.</em></p><p> </p><p>Penelitian ini bertujuan untuk mengetahui pengaruh kepercayaan sebagai variabel pemediasi promosi politik dan citra kandidat terhadap keputusan pemilihan Kepala Desa Siulak kecil Hilir Tahun 2016. Sampel dalam penelitian ini adalah pemilih yang menggunakan hak pilihnya yang berjumlah 263 pemilih dengan metode pengambilan sampel menggunakan cara acak sederhana. Data dikumpulkan melalui kuesioner dengan skala Likert yang dianalisis dengan metode deskriptif kualitatif dan deskriptif kuantitatif seperti uji validitas dan reliabilitas, koefisien determinasi, uji hipotesis dengan analisis regresi bertingkat dengan pengolahan data menggunakan SPSS 19.0 for windows. Hasil penelitian menemukan bahwa: a) Promosi politik dan citra kandidat berpengaruh signifikan terhadap kepercayaan dan keputusan pemilihan Kepala Desa Siulak Kecil Hilir. b) Kepercayaan berpengaruh signifikan terhadap keputusan pemilihan Kepala Desa. Disamping itu, c) Kepercayaan berperan sebagai variabel pemediasi antara promosi politik dan citra kandidat terhadap keputusan pemilihan Kepala Desa Siulak Kecil Hilir, Kerinci. Hasil penelitian ini memberikan rekomendasi praktis khususnya kepada para kandidat Kepala Desa di masa yang akan datang, meningkatkan kepercayaan melalui peningkatan promosi politik dan citra kandidat.</p>
Analisis Naratif Berita dalam Majalah Tempo Edisi 20-26 Mei 2019 sebagai Alternatif Bahan Ajar Mata Kuliah Bahasa Indonesia
Authors: Musdolifah Ari 
Published: July 2019

Abstrak
Penelitian ini dilatarbelakangi kurangnya pemahaman mahasiswa Program Studi Pendidikan Bahasa dan Sastra Indonesia semester 1 Universitas Balikpapan. tentang keterampilan menulis, khususnya pada materi menulis paragraf dan menulis artikel ilmiah pada Mata Kuliah Bahasa Indonesia. Tujuan penelitian ini adalah mendeskripsikan analisis naratif berita dalam Majalah Tempo dan implementasi struktur narasi pada Mata Kuliah Bahasa Indonesia. Penelitian ini menggunakan metode deskriptif dengan jenis penelitian kualitatif. Teknik analisis data dalam penelitian ini menggunakan teknik analisis naratif oleh Tzevetan Todorov dengan struktur narasi yang dimodifikasi oleh Nick Lacey dan Gillespie. Hasil penelitian ini menunjukkan bahwa struktur narasi yang terdapat pada berita “Detik-Detik yang Menentukan”, “Satu Pemilu Dua Sikap”, “Cacar Monyet di Negeri Singa”, “Siberut Terancam Hutan Industri”, “Bukti Campur Tangan Menteri Lukman”, “Jerat Makar Pengancam Presiden”, terdapat lima berita yang menyajikan persitiwa secara kronologis dan satu berita yang tidak kronologis. Berdasarkan hasil implementasi struktur narasi pada Majalah Tempo edisi 20-26 Mei 2019, diketahui hasil tulisan paragraf narasi yang memiliki urutan peristiwa secara kronologis adalah 88,2% dan tulisan artikel ilmiah yang memenuhi syarat sesuai dengan indikator sistem penulisan artikel ilmiah adalah 82,3%.
Kata kunci: Struktur narasi, berita, majalah Tempo

Abstract
This research is motivated by a lack of understanding of students in the 1st semester of Indonesian Language and Literature Education Study Program at University of Balikpapan. about writing skills, especially in writing paragraphs and writing scientific articles on Indonesian Language Courses. This research uses descriptive method with qualitative research to describe the structure of news narratives in Tempo Magazine. Data analysis techniques in this study used narrative analysis techniques by Tzevetan Todorov with a narrative structure modified by Nick Lacey and Gillespie. The results of this study indicate that the structure of the narrative contained in the news “Determining Seconds”, “One Election Two Attitudes”, “Monkey Smallpox in the Lion Country”, “Siberut Threatened by Industrial Forests”, “Interference Proof of Minister Lukman”, “Pitfalls of the President's Threat”, there are five news items that present chronologically and two news that is not chronological. Based on the implementation of the narrative structure at the magazine Tempo 20-26 edition 2019 may show that paragraph narrative writing having a sequence of events in chronological order is 88,2 % and in writing scholarly article qualified in accordance with an indicator of a writing system scientific article is as much as 82,3 %.
Keywords: Narrative structure, news, Tempo magazine.
PENGARUH E-LEARNING SCHOOLOGY TERHADAP HASIL BELAJAR PEMROGRAMAN WEB DAN PERANGKAT BERGERAK SISWA (Studi Kasus : Kelas XI RPL di SMK Negeri 1 Negara)
Authors: Sulistyawati Candra , Agustini Ketut , Pradnyana Gede Aditra 
Published: July 2019

ABSTRAKTujuan penelitian ini untuk mengetahui (1) pengaruh e-learning schoology terhadap hasil belajar siswa mata pelajaran Pemrograman Web dan Perangkat Bergerak kelas XI RPL di SMK Negeri 1 Negara, (2) respon siswa setelah menggunakan e-learning schoology pada mata pelajaran Pemrograman Web dan Perangkat Bergerak kelas XI RPL di SMK Negeri 1 Negara. Jenis penelitian ini adalah eksperimen semu (quasi eksperimen) dengan desain Post Test Only Control Group Design. Populasi penelitian mencakup seluruh siswa kelas XI RPL di SMK Negeri 1 Negara Tahun Pelajaran 2018/2019. Sampel penelitian yang digunakan yaitu kelas XI RPL 1 sebagai kelompok kelas eksperimen dan kelas XI RPL 2 sebagai kelompok kelas kontrol dengan jumlah sampel 70 orang. Metode pengumpulan data yang digunakan yaitu metode tes dalam bentuk tes essay untuk mengetahui ranah kognitif dan metode angket atau kuesioner untuk mengetahui respon siswa. Data hasil belajar dianalisis melalui uji prasyarat yaitu meliputi uji normalitas dan uji homogenitas dengan hasil kedua kelompok berdistribusi normal dan homogen, dilanjutkan dengan uji hipotesis yang menggunakan uji t. Hasil penelitian diperoleh thitung 7,1916 yang lebih besar dari ttabel 1,9955 yang menyatakan bahwa (1) terdapat perbedaan hasil belajar yang lebih tinggi antara siswa yang belajar dengan menggunakan e-learning schoology dengan siswa yang belajar dengan menggunakan power point. Hal ini dapat dilihat dari rata-rata kelompok eksperimen adalah sebesar 32,72 dan rata-rata kelompok kontrol adalah 27,56. (2) respon siswa dari penggunaan e-learning schology pada mata pelajaran Pemrograman Web dan Perangkat Bergerak adalah sangat positif dilihat dari rata-rata skor hasil angket respon siswa yaitu 84,72. Kata kunci: E-learning, Hasil Belajar, Pemrograman Web dan Perangkat Bergerak, Schoology
Antibacterial activity of selected snake venoms on pathogenic bacterial strains
Authors: Boda Francisc Andrei , Mare Anca , Szabó Zoltán István , Berta Lavinia , Curticapean Augustin , Dogaru Maria , Man Adrian 
Published: July 2019

Abstract
Snake venoms are aqueous solutions containing peptides and proteins with various biochemical, physiological, and pathophysiological effects. Several snake venom components are used as lead molecules in the development of new active substances for the treatment of cardiovascular diseases, clotting disorders, cancer or pain.
Antibacterial activity has also been attributed to snake venoms and proteins isolated from snake venoms. This study provides information regarding the antibacterial activity of venoms obtained from various snake species from the Elapidae and Viperidae families. Minimum inhibitory and bactericidal concentrations of snake venoms were determined for three Gram-positive (Enterococcus faecalis ATCC 29212, Staphylococcus aureus ATCC 29213, and Methicillin-resistant Staphylococcus aureus ATCC 43300) and three Gram-negative (Escherichia coli ATCC 25922, Klebsiella pneumoniae ATCC 13883, and Pseudomonas aeruginosa ATCC 27853) pathogenic bacteria. The observed effects were correlated with the protein content of each venom, determined using SDS-PAGE analysis and comparison with data available in the literature. Our findings represent a starting point for the selection of snake venoms containing components with potential use as lead molecules in the development of new antibacterial agents, targeting multidrug resistant bacterial strains.
Magnesium isoglycyrrhizinate protects against concanavalin A-induced immunological liver injury in a mouse model
Authors: Jiang Zhengyan , Zheng Liang 
Published: July 2019

Abstract

Background: To evaluate the protective effects of magnesium isoglycyrrhizinate on a mouse model of concanavalin A (ConA)-induced immunological liver injury. Materials and Methods: Forty-eight mice were randomly divided into a normal control group, a model group, three dose groups of magnesium isoglycyrrhizinate (12.5, 25, 50 mg/kg) and a dexamethasone group (2.5 mg/kg). Magnesium isoglycyrrhizinate was intraperitoneally injected for 5 consecutive days, and the model of immunological liver injury was established on the fifth day after caudal vein injection of ConA (20 mg/kg). Blood was collected to detect the activities of alanine transaminase (ALT) and aspartate transaminase (AST) as well as the levels of tumor necrosis factor-α (TNF-α) and interferon-γ (IFN-γ). The levels of neopterin (NP) and malondialdehyde (MDA) and the activities of myeloperoxidase (MPO) and superoxide dismutase (SOD) in liver tissues were measured, and histopathological changes were observed. Results: The serum levels of ALT and AST in the model group increased. Hepatic lobules had necrotic foci and inflammatory cell infiltration. The plasma levels of TNF-α and IFN-γ increased. In liver tissues, the levels of NP, MDA and MPO rose, but that of SOD decreased. Magnesium isoglycyrrhizinate significantly attenuated the activities of ALT and AST (P<0.05). Histopathological staining showed that inflammation of the liver was relieved significantly. Magnesium isoglycyrrhizinate also decreased the levels of NP, MDA and MPO in liver tissues (P<0.05), raised that of SOD and reduced the plasma levels of TNF-α and IFN-γ (P<0.05). Conclusion: Magnesium isoglycyrrhizinate protected against ConA-induced immunological liver injury in mice, probably through immune regulation and antioxidation.
Effects of obstruent voicing on vowel F0: Implications for laryngeal realism
Authors: Kirby James , Ladd D. Robert 
Published: July 2019

AbstractIt is sometimes argued that languages with two-way laryngeal contrasts can be classified according to whether one series is realized canonically with voicing lead or the other with voicing lag. In languages of the first type, such as French, the phonologically relevant feature is argued to be [voice], while in languages of the second type, such as German, the relevant feature is argued to be [spread glottis]. A crucial assumption of this position is that the presence of certain contextually stable phonetic cues, namely voicing lead or lag, can be used to diagnose the which feature is phono-logically active.In this paper, we present data on obstruent-intrinsic F0 perturbations (CF0) in two [voice] languages, French and Italian. Voiceless obstruents in both languages are found to raise F0, while F0 following (pre)voiced obstruents patterns together with sonorants, similar to the voiceless unaspirated stops of [spread glottis] languages like German and English. The contextual stability of this cue implies that an active de-voicing gesture is common to languages of both the [voice] and [spread glottis] types, and undermines the idea that a strict binary dichotomy between true voicing and aspirating languages can be reliably inferred based on properties of the surface phonetics.
Colecistectomía Laparoscópica: experiencia de dos décadas en el hospital militar de Cuenca, Ecuador
Authors: Buri Parra Iván Eduardo , Ulloa Gómez Felipe Ismael , Vega Cuadrado Henry David , Encalada Torres Lorena Esperanza 
Published: July 2019

Objetivo: identificar los factores socio-demográficos y clínicos, en la colecistectomía laparoscópica en dos décadas de experiencia en el Hospital Militar de la ciudad de Cuenca. La colecistectomía es la cirugía más común para tratar patologías como la colelitiasis, colecistitis agudas y poliposis vesicular, siendo en la actualidad la técnica laparoscópica el tratamiento de elección. Materiales y Métodos: estudio de tipo descriptivo, retrospectivo, de pacientes sometidos a colecistectomía laparoscópica en las últimas dos décadas; se trabajaron con 468 historias clínicas que cumplieron los criterios de inclusión. Resultados: un 61,8% fueron mujeres con una edad media de 50,77 años y un desvío estándar (DS) de 0,727. Las indicaciones quirúrgicas fueron colelitiasis 60,2%, colecistitis aguda 29,2%, poliposis vesiculares 4,7%, coledocolitiasis 4,5%, vesícula esclerotrófica 0,9%. La estancia postoperatoria fue de 80,6% menos de tres días y el 19,4% igual o mayor a 4 días; con un promedio de 1,09 y un DS=0,292. El porcentaje de conversión a cirugía abierta fue del 0,4%. El tiempo quirúrgico fue en 50,2% dentro de 31-60min y 46,2% más de 60 minutos con un promedio de 42,43min y un DS=0,564. Al relacionar la edad y el tiempo operatorio se evidenció que en los mayores de 60 años tenían más días de hospitalización con significancia estadística, con un valor de p=0,0006. Conclusión: La colecistectomía laparoscópica disminuye los tiempos operatorios y de hospitalización, contribuyendo directamente al descenso de la morbilidad y mortalidad por este tipo de patologías y permitiendo a los servicios de salud, de países en vías de desarrollo, mejorar la calidad de la atención de sus poblaciones.
PERILAKU PETERNAK DALAM PEMOTONGAN SAPI BETINA PRODUKTIF (STUDI KASUS RPH KOTA AMBON)
Authors: Bennu Nur Rifai , Pattiselanno August E , Girsang Wardis 
Published: July 2019

Penelitian ini bertujuan untuk mengetahui tingkat pengetahuan masyarakat peternak dan menganalisis faktor-faktor yang mempengaruhi jumlah pemotongan sapi betina produktif. Jenis penelitian ini adalah studi kasus dengan metode survey. Populasi dan jumlah sampel dalam penelitian ini sebanyak 38 orang, dengan persentase 50 % dari jumlah populasi, kecuali pelaku usaha/jagal dan para pakar persentasenya 100 % dari jumlah populasi. Analisa data yang digunakan adalah analisis kualititaf dan statistik deskriptif. Hasil analisis terkait faktor-faktor yang mempengaruhi jumlah pemotongan adalah 1) Kebutuhan ekonomi keluarga sebesar 44,74%. 2). Membutuhkan uang 34,21%. 3). Kurangnya sosialisasi tentang pemotongan sapi betina produktif 55,26% dan 4). Pengawasan di RPH lemah 65,53%. Hasil analisis regresi menghasilkan persamaan: Y= -117.8 + - 0.000000 X1 + 0.000028 X2 + e. Hasil analisis dengan menggunakan regresi linier berganda menunjukkan bahwa faktor yang mempengaruhi pemotongan (penjualan) betina produktif secara signifikan oleh peternak adalah harga sapi betina produktif itu sendiri. Peternak menjual betina produktif karena kebutuhan keluarga, meskipun harga betina produktif tidak semahal ternak sapi jantan. Pendapatan peternak secara keseluruhan tidak mempengaruhi jumlah pemotongan (penjualan) betina produktif. Penjualan betina produktif tidak bersifat permanen, tetapi hanya karena kebutuhan keluarga yang mendesak.
New Zealand Plant Protection Society Research Scholarship
Authors: McCarthy Hannah 
Published: July 2019

The necrotrophic fungus Ciborinia camelliae Kohn causes a disease known as camellia petal blight that has been disfiguring camellia flowers (Fig. 1) since it was first found in New Zealand in 1993. This blight has severally impacted the camellia seed oil industry, floriculture industry, and has been a great frustration to keen camellia growers over the last 25 years but no viable control methods for camellia petal blight have been discovered so far. The Camellia Memorial Trust has helped fund a research team at Massey University to study the interaction between
camellia plants and this pathogen. Hannah McCarthy, recipient of the 2017/2018 New Zealand Plant Protection Society Research Scholarship, is part of this team. Ciborinia camellia is host and tissue specific, which restricts its infection capability to flowers of the Camellia genus. This disease spreads by ascospores, which after landing on a susceptible Camellia spp. bloom, germinate to grow hyphae and cause necrosis and death of the petal tissues. The flower then falls prematurely to the ground, where the fungus survives as hardened sclerotium until the next flowering season.
Most plant pathogens utilise a range of proteins to promote infection using mechanisms that include the suppression of plant immunity, degradation of cell walls, or the manipulation of the host’s immunity to their own advantage. These proteins are known as ‘eï¬€ectors’ and identification of these complex molecules has led to a better understanding of disease and new disease-control strategies for other plants. The aim of Hannah’s MSc research is to identify eï¬€ectors in Ciborinia camelliae, and she has been focusing on a protein family that shares characteristics (such as high cysteine content and the size of protein sequences) with known eï¬€ectors from other fungi. This protein family is called Ciborinia camelliae-like small secreted proteins (CCL-SSPs). There are 73 unique protein sequences in Ciborinia camelliae but of the ten tested for necrotic ability by recombinant expression and infiltration into camellia petals, none were found to induce cell death. However, a protein found in the closely related fungus Sclerotinia sclerotiorum, was found to induce very rapid cell death, which was visible just two hours after infiltration. This protein from Sclerotinia sclerotiorum has high sequence similarity to CCL- SSPs. To identify the function of this protein family, Hannah is performing region swaps between the S. sclerotiorum protein and a Ciborinia camelliae CCL-SSP. By the end of
this project, the research team hopes to have: (a) identified the region of the S. sclerotiorum protein responsible for its necrotic activity; (b) compared this region with sequences of Ciborinia camelliae CCL-SSPs; and (c) deduced the likely function of this protein family, and its role in camellia petal blight.
Idosos atendidos em unidade básica de saúde: experiências sobre polimedicação
Authors: Silva Cathia Valadão , Higa Elza de Fátima Ribeiro , Marin Maria José Sanches , Goulart Flávia Cristina , Lazarini Carlos Alberto 
Published: July 2019

Resumo: O envelhecimento acarreta múltiplas alterações e doenças, intensificando, assim, a necessidade de recursos de saúde. A literatura aponta que, nesta fase da vida, é frequente a polimedicação, caracterizada pelo uso de cinco ou mais medicamentos. Logo, objetivou-se compreender as experiências de idosos sobre o significado da polimedicação. Pesquisa com abordagem qualitativa, a partir de entrevistas com 14 idosos, atendidos em Unidade Básica de Saúde, as quais foram gravadas, transcritas e, posteriormente, submetidas à técnica de Análise de Conteúdo, modalidade temática. Na análise, emergiram três categorias temáticas: Saúde e longevidade, Quantidade excessiva, e Confiança no médico. Idosos usuários de Unidade Básica de Saúde, ao serem estimulados a refletir sobre o significado do uso diário de cinco ou mais medicamentos, expressaram experiências acerca da polimedicação.Palavras-chave: Idosos; Polimedicação; Centros de Saúde. Elderly attended in the basic health unit: experiences on polymedicationAbstract: Aging brings multiple changes and diseases, thus intensifying the need for health resources. The literature indicates that, at this stage of life, polymedication is frequent, characterized by the use of five or more drugs. Therefore, it was aimed to understand the experiences of the elderly about the meaning of the polymedication. Research with a qualitative approach, based on interviews with 14 elderly people, attended at a Basic Health Unit, which were recorded, transcribed and later submitted to the Content Analysis technique, thematic modality. In the analysis, three thematic categories emerged: Health and longevity, Excessive Quantity, and Trust in the physician. Elderly users of the Basic Health Unit, when being stimulated to reflect on the meaning of the daily use of five or more medications, expressed experiences about the polymedication.Keywords: Elderlies; Polypharmacy; Health Center.