bluuebunny/crossref_metadata_2025_split huggingface dataset:
SNF1 controls the glycolytic flux and mitochondrial respiration
Authors: Martinez‐Ortiz Cecilia , Carrillo‐Garmendia Andres , Correa‐Romero Blanca Flor , Canizal‐García Melina , González‐Hernández Juan Carlos , Regalado‐Gonzalez Carlos , Olivares‐Marin Ivanna Karina , Madrigal‐Perez Luis Alberto 
Published: May 2019

AbstractThe switch between mitochondrial respiration and fermentation as the main ATP production pathway through an increase glycolytic flux is known as the Crabtree effect. The elucidation of the molecular mechanism of the Crabtree effect may have important applications in ethanol production and lay the groundwork for the Warburg effect, which is essential in the molecular etiology of cancer. A key piece in this mechanism could be Snf1p, which is a protein that participates in the nutritional response including glucose metabolism. Thus, this work aimed to recognize the role of the SNF1 gene on the glycolytic flux and mitochondrial respiration through the glucose concentration variation to gain insights about its relationship with the Crabtree effect. Herein, we found that SNF1 deletion in Saccharomyces cerevisiae cells grown at 1% glucose, decreased glycolytic flux, increased NAD(P)H concentration, enhanced HXK2 gene transcription, and decreased mitochondrial respiration. Meanwhile, the same deletion increased the mitochondrial respiration of cells grown at 10% glucose. Altogether, these findings indicate that SNF1 is important to respond to glucose concentration variation and is involved in the switch between mitochondrial respiration and fermentation.
How Are Agile Release Trains Formed in Practice? A Case Study in a Large Financial Corporation
Authors: Putta Abheeshta , Paasivaara Maria , Lassenius Casper 
Published: May 2019

AbstractThe Scaled Agile Framework (SAFe) is currently the most widely adopted framework for scaling agile in the software intensive industry. Despite this, there exists very little scientific research on the transformation process, as well as on the challenges and success factors of using SAFe in large-scale organizations. To start filling in this research gap, we conducted a case study by investigating the formation of agile release trains and the related challenges in a large financial organization adopting SAFe. We conducted 24 interviews with 27 interviewees, after which we analyzed the transcribed interviews using open and axial coding.The SAFe transformation started by forming a pilot train with teams that already had experience in agile practices. The success of the pilot led to the launching of new release trains. The forming of new agile release trains was challenging due to politics, difficulties in identifying the value streams, and the avoidance of a radical restructuring of the organization. These challenges led to opting for an organic way of transformation.Management organized several workshops to identify stakeholders for the second train. This was followed by team members choosing their teams based on skills and interests. The last two trains were formed using Lego workshops. The most significant challenges after forming the release trains at the case organization were struggles with existing projects and challenges due to inter-train dependencies.
Scaling Agile Beyond Organizational Boundaries: Coordination Challenges in Software Ecosystems
Authors: Figalist Iris , Elsner Christoph , Bosch Jan , Olsson Helena Holmström 
Published: May 2019

AbstractThe shift from sequential to agile software development originates from relatively small and co-located teams but soon gained prominence in larger organizations. How to apply and scale agile practices to fit the needs of larger projects has been studied to quite an extent in previous research. However, scaling agile beyond organizational boundaries, for instance in a software ecosystem context, raises additional challenges that existing studies and approaches do not yet investigate or address in great detail. For that reason, we conducted a case study in two software ecosystems that comprise several agile actors from different organizations and, thereby, scale development across organizational boundaries, in order to elaborate and understand their coordination challenges. Our results indicate that most of the identified challenges are caused by long communication paths and a lack of established processes to facilitate these paths. As a result, the participants in our study, among others, experience insufficient responsivity, insufficient communication of prioritizations and deliverables, and alterations or loss of information. As a consequence, agile practices need to be extended to fit the identified needs.
Enterprise Agility: A Balancing Act - A Local Government Case Study
Authors: Barroca Leonor , Sharp Helen , Dingsøyr Torgeir , Gregory Peggy , Taylor Katie , AlQaisi Raid 
Published: May 2019

AbstractAusterity and financial constraints have been threatening the public sector in the UK for a number of years. Foreseeing the threat of continued budget cuts, and addressing the situation many local councils face, requires internal transformations for financial stability without losing the key focus on public service. Agile transformations have been undertaken by organisations wanting to learn from the software development community and bringing agile principles into the wider organisation. This paper describes and analyses an ongoing behaviour-led transformation in a district council in the UK. It presents the results of the analysis of 19 interviews with internal stakeholders at the council, of observations of meetings among senior and middle management in a five-month period. The paper explores the successes and the challenges encountered towards the end of the transformation process and reflects on balancing acts to address the challenges, between: disruption and business as usual, empowerment and goal setting, autonomy and processes and procedures, and behaviours and skills. Based on our findings, we suggest that behaviours on their own cannot guarantee a sustained agile culture, and that this is equally important for enterprise agility and for large-scale agile software development transformations.
The Product Owner in Large-Scale Agile: An Empirical Study Through the Lens of Relational Coordination Theory
Authors: Berntzen Marthe , Moe Nils Brede , Stray Viktoria 
Published: May 2019

AbstractIn agile software development, a core responsibility of the product owner (PO) is to communicate business needs to the development team. In large-scale agile software development projects, many teams work toward an overall outcome, but they also need to manage interdependencies and coordinate efficiently. In such settings, POs need to coordinate knowledge about project status and goal attainment both within and across the development teams. Previous research has shown that the PO assumes a wide set of roles. Still, our knowledge about how POs coordinate amongst themselves and with their teams in large-scale agile is limited. In this case study, we explore PO coordination in a large-scale development program through the theoretical lens of Relational Coordination Theory. Our findings suggest that (1) coordination varies depending on the context of each PO, (2) a focus on achieving high-quality communication changes coordination over time, and (3) unscheduled coordination enables of high-quality communication.
Chronic Postoperative Opioid Use: A Systematic Review
Authors: Hinther Ashley , Abdel‐Rahman Omar , Cheung Winson Y. , Quan May Lynn , Dort Joseph C. 
Published: May 2019

AbstractBackgroundThere are a number of studies in the literature that describe the prevalence, causes, and factors associated with chronic postoperative opioid use, but there is a lack of synthesis of the literature to guide clinicians in optimally managing postoperative pain while avoiding opioid dependence. Thus, the goal of this study was to perform a systematic review of the literature to investigate the prevalence of chronic postoperative opioid use and the associated risk factors.Materials and methodsA systematic search was performed using Ovid Medline and Embase according to PRISMA guidelines. Data were collected on the following outcomes of interest: prevalence of opioid use at 3, 6, and 12 months postoperatively, and risk factors associated with chronic postoperative opioid use.ResultsForty‐three articles were included in the final analysis. The mean prevalence of chronic postoperative opioid use in all populations at 3, 6, and 12 months postoperatively was 30.5%, 25.6%, and 25.2%, respectively. The prevalence of patients who developed chronic opioid use at 3, 6, and 12 months postoperatively was 10.4%, 8.5%, and 9.8%, respectively. Forty of the articles analyzed risk factors associated with chronic postoperative opioid use. The most common associated risk factor identified was preoperative opioid use with 27 articles demonstrating a significant association with chronic postoperative opioid use.DiscussionThe current opioid crisis is in part secondary to the prevalence of chronic opioid use following surgery. This study identified associated risk factors with chronic postoperative opioid use, which may help identify patients at risk for developing chronic postoperative opioid use.
Impact of content characteristics and emotion on behavioral engagement in social media: literature review and research agenda
Authors: Schreiner Melanie , Fischer Thomas , Riedl Rene 
Published: May 2019

AbstractWe present a review of N = 45 studies, which deals with the effect of characteristics of social media content (e.g., topic or length) on behavioral engagement. In addition, we reviewed the possibility of a mediating effect of emotional responses in this context (e.g., arousing content has been shown to increase engagement behavior). We find a diverse body of research, particularly for the varying content characteristics that affect engagement, yet without any conclusive results. We therefore also highlight potential confounding effects causing such diverging results for the relationship between content characteristics and content engagement. We find no study that evaluates the mediating effect of emotional responses in the content—engagement relationship and therefore call for further investigations. In addition, future research should apply an extended communication model adapted for the social media context to guarantee rigorous research.
A Phragmén–Lindelöf Theorem via Proximate Orders, and the Propagation of Asymptotics
Authors: Jiménez-Garrido Javier , Sanz Javier , Schindl Gerhard 
Published: May 2019

Abstract
We prove that, for asymptotically bounded holomorphic functions in a sector in $$\mathbb {C},$$

C
,

an asymptotic expansion in a single direction towards the vertex with constraints in terms of a logarithmically convex sequence admitting a nonzero proximate order entails asymptotic expansion in the whole sector with control in terms of the same sequence. This generalizes a result by Fruchard and Zhang for Gevrey asymptotic expansions, and the proof strongly rests on a suitably refined version of the classical Phragmén–Lindelöf theorem, here obtained for functions whose growth in a sector is specified by a nonzero proximate order in the sense of Lindelöf and Valiron.
Diverse Polyphenols from Hypericum faberi
Authors: Zhang Xin-Wen , Ye Yan-Song , Xia Fan , Yang Xing-Wei , Xu Gang 
Published: May 2019

Abstract
Six new polyphenols with different isoprenylated xanthones, isoprenylated acylphloroglucinols, and chromone architectures, hyperfaberols A–F (1–6), were isolated from the whole plants of Hypericum faberi along with seven other related known compounds. In which hyperfaberols A/B (1/2) and 12–13 were isoprenylated xanthones, hyperfaberols C–E (3–5) and 8–11 were seven isoprenylated acylphloroglucinol derivatives, while 6–7 were two chromones. Their structures were elucidated by comprehensive analysis of their spectroscopic data as well as detailed comparison with the literature data. Compounds 1 and 11 showed cytotoxities against the human esophageal cancer cell line (ECA-109) and the pancreatic tumor cell line (PANC-1) in vitro, respectively.

Graphical Abstract
Cap: connecting FaceReader™ to z-Tree
Authors: Doyle Leonard , Schindler David 
Published: May 2019

AbstractμCap is a software package (citeware) for economic experiments enabling experimenters to analyze emotional states of subjects using z-Tree and FaceReader™. μCap is able to create videos of subjects on client computers based on stimuli shown on screen and restrict recording material to relevant time frames. Another feature of μCap is the creation of time stamps in csv format at prespecified screens (or at prespecified points in time) during the experiment, measured on the client computer. The software makes it possible to import these markers into FaceReader™ easily. μCap is the first program that significantly simplifies the process of connecting z-Tree and FaceReader™ with the additional benefit of extremely high precision. This paper describes the usage, underlying principles as well as advantages and limitations of μCap. Furthermore, we give a brief outlook of how μCap can be beneficial in other contexts.
SOCIAL BROKERS AND LEFTIST–SADRIST COOPERATION IN IRAQ'S REFORM PROTEST MOVEMENT: BEYOND INSTRUMENTAL ACTION
Authors: Robin-D'Cruz Benedict 
Published: May 2019

AbstractThis article develops a concept of social brokerage to explain leftist–Sadrist cooperation during Iraq's 2015 protest movement. Conventional understanding holds that Iraq's secular-leftist civil trend and Shiʿi Islamist factions have been mutually isolated, and at times fierce antagonists, in Iraq's post-2003 politics. This view has been challenged by an emergent political alliance between a faction of the civil trend and the Shiʿi Islamist Sadrist movement. By comparing this alliance with the failure of another Shiʿi Islamist group, ʿAsaʾib Ahl al-Haq, to involve itself with and exploit the protest movement, this article isolates the conditions which determined the dynamics of leftist–Islamist interactions. Shifting the focus away from elite politics and structural-instrumental explanations favored by rational choice models, this article reveals a longer backstory of social and ideological interactions between less senior actors that transgressed leftist–Islamist social boundaries. From this context, potential brokers emerged, capable of skilfully mediating leftist–Sadrist interactions.
Liberalism and Republicanism: Friends or Foes? A Reply to Richard Dagger
Authors: Sandel Michael J. 
Published: May 2019

I am grateful to Professor Dagger for his insightful critique. He brings out the continuities and differences betweenDemocracy's Discontentand my earlier work with subtlety and care. He writes in defense of liberalism, but not without sympathy for many of the ideals I invoke in the name of republicanism—civic virtue, encumbered selves, obligations of membership, the formative project. In fact, his republican sympathies are so expansive that I found myself unsure at times whether I could identity a fundamental disagreement.Professor Dagger's basic objection, as I understand it, is this: I overstate the opposition between liberalism and republicanism, between autonomy and civic virtue; in drawing these distinctions too sharply, I fail to acknowledge the elements of liberalism I implicitly affirm. Professor Dagger accepts the importance of civic virtue and the formative project. But he considers it a mistake to oppose liberalism as vigorously as I do, and “particularly wrong to oppose republicanism to liberalism.” Instead, he favors a “hybrid” of liberalism and republicanism that combines autonomy and civic virtue. Any republicanism worth defending must include “a commitment to liberal principles, such as tolerance, fair play, and respect for the rights of others.”Whether liberalism and republicanism are compatible doctrines depends on how they are conceived. At a certain level of generality, there is no necessary conflict: the liberal tradition stands for toleration and individual rights, while the republican tradition stands for government by the people. Liberal rights support republican self rule by preventing the majority from oppressing the minority, while the republican emphasis on civic virtue restrains individuals from abusing their rights and ignoring the common good.
Total and Attributable Costs of Surgical-Wound Infections at a Canadian Tertiary-Care Center
Authors: Zoutman Dick , McDonald Shirley , Vethanayagan Dilini 
Published: May 2019

ABSTRACTOBJECTIVE: To determine the total and attributable costs of surgical-wound infections in a Canadian teaching hospital.DESIGN: Retrospective incidence series study with chart review and examination of resource utilization attributable to wound infection. The charts of inpatients with wound infections were examined using the Appropriateness Evaluation Protocol (AEP), a validated chart review instrument designed to determine appropriateness of care, modified for wound infections.SETTING: A university referral center in Canada.PATIENTS: Medical records were abstracted from patients with wound infections who underwent an inpatient clean or clean-contaminated procedure during 1991.MEASUREMENTS: During the wound-infection treatment period, the hospital costs associated with providing care were tabulated for all inpatient days and for outpatient and emergency visits. Costs taken into account included nursing salary and benefits, nonphysician professional services, operating room time, laboratory, pharmacy, supplies, ancillary tests, and hotel costs.RESULTS: We identified 108 wound infections. Twenty-two patients required 28 surgical procedures related to a wound infection. Inpatient days totalled 1,116, costing $394,337. Fifty-five emergency and 42 clinic visits occurred, costing $27,193. By applying the AEP to the inpatient days, 833 days, or 10.2 days per case, were directly attributable to the wound infection. The hospital costs for inpatient care attributable to wound infections were $321,533 in total, or $3,937 per infection. Costs were distributed as follows: nursing, 51%; hotel, 14%; pharmacy, 10%; laboratory, 9%; emergency and outpatient clinic, 6%; professional services, 5%; operating room, 3%; and ancillary tests, 2%.CONCLUSIONS: Wound infections contribute markedly to extra days of hospitalization and related costs. The AEP method is applied easily to determine attributable days of care and costs of wound infections, which are necessary to calculate the cost-benefit of infection control programs.
Emoties en het Hart; resultaten van neurocardiologisch onderzoek bij de Biologische Psychiatrie Groningen
Authors: Ter Horst G.J. 
Published: May 2019

SamenvattingAutonome functies en emoties worden beide gestuurd door het limbische systeem; een groep kernen in de voorhersenen die voor het eerst als zodanig beschreven zijn door Papez in 1937. Ondanks jarenlang fundamenteel wetenschappelijk onderzoek rijzen nog steeds vele vragen over de bouw en functies van het limbische systeem, met inline waar het de rol van dit systeem betreft bij emotionele stoornissen zoals angst en depressie. Fundamenteel neurobiologisch onderzoek van cardiovasculaire autonome sturing biedt de mogelijkheid inzicht le verkrijgen in de bouw van limbische neuronale circuits. In deze publicatie wordt een overzicht gegeven van de vorderingen op dit gebied. De bouw van de limbische cardiovasculaire circuits zal worden beschreven aan de hand van resultaten verkregen met verschillende - moderne - neurobiologische technieken. Ook het effect van typische en atypische antipsychotica in deze circuits zal warden gepresenteerd.
Potential climatic control of seedbank density
Authors: Pakeman Robin J. , Cummins Roger P. , Miller Gordon R. , Roy David B. 
Published: May 2019

AbstractThe relationship between Calluna vulgaris seedbank density and climate was investigated using regression analysis and two related techniques (factor-ceiling analysis). The seedbank data originated from published and unpublished studies. Low seedbank densities were associated with sites in the relatively dry, sunny and warm south and east of Great Britain. However, as the climatic variables used in the study were highly intercorrelated, it was not possible to determine which climatic variable had the greatest influence on seedbank density. A hypothesis is described suggesting that the limits of seedbank density can be described for single environmental factors. The operation of other environmental and management factors may reduce the seedbank density to less than this maximum. This is illustrated for a range of climatic variables using factor-ceiling analysis. The processes following seed deposition and the longevity of seeds in the soil are highlighted as possible factors controlled by climate which determine seedbank density.
The role of abscisic acid in germination of light-sensitive and light-insensitive lettuce seeds
Authors: Roth-Bejerano Nurit , Sedee Norbert J.A. , van der Meulen Rene M. , Wang Mei 
Published: May 2019

AbstractThe role of abscisic acid (ABA) in seed germination of two cultivars of lettuce (Lactuca sativa L.; light-sensitive Ritsa and light-insensitive Strada) was investigated. The inhibition of Ritsa seed germination by exogenous ABA was higher than that of Strada seeds, the extent of inhibition of both cultivars being reduced by a short light break. At 25°C the sensitivity of both cultivars to exogenous ABA was higher than at 15°C. The endogenous level of ABA was similar in dry seeds of both cultivars, increasing temporarily in Ritsa seeds during the first 4 h of imbibition in darkness but not in Strada seeds, nor in Ritsa seeds exposed to a short light break. The transitory increase of ABA content in Ritsa seeds imbibed in darkness was accompanied by increased expression of the gene responsive to ABA (Rab) under these conditions. Zorial (Norflurazone), an ABA-biosynthesis inhibitor, decreased ABA content and allowed dark germination of the light-requiring Ritsa seeds. A short light break induced germination of Ritsa seeds when applied at 24 and 48 h after imbibition onset, i.e. after the transitory increase of ABA. GA3, on the other hand was effective when applied at the beginning of imbibition. It seems that light induces germination of the photoblastic Ritsa seeds by both inhibiting ABA synthesis and decreasing seed sensitivity to ABA and inhibitory processes induced by it.
Monumental Decisions: How Direct Democracy Shapes Attitudes in the Conflict over Confederate Memorials
Authors: Johnson Tyler , Tipler Kathleen , Camarillo Tyler 
Published: May 2019

ABSTRACTAmericans are engaged in a heated, sometimes violent, debate over the fate of Confederate monuments. As communities decide whether to remove these monuments, elected and appointed officials typically have had the final say. What if instead of allowing elected officials to make such decisions, voters had the power? Would this affect how the public feels about the outcome, win or lose? We used a survey experiment to examine whether the mode of decision making affects public attitudes, testing the effects of a decision made by public referendum versus by a city council. We found that respondents view decisions made by referendum to be fairer and more legitimate and allow multiple perspectives to be heard. These results hold even for respondents who oppose the referendum’s outcome. Our results speak to the potential of direct democracy to enhance public acceptance of decisions, particularly when the public is divided.