bluuebunny/crossref_metadata_2025_split huggingface dataset:
A plane-wave formulation and numerical analysis of elastic multicomponent inverse scattering series internal multiple prediction
Authors: Sun Jian , Innanen Kristopher A. 
Published: June 2019

Internal multiple prediction and removal is a critical component of seismic data processing prior to imaging, inversion, and quantitative interpretation. Inverse scattering series methods predict multiples without identification of generators, and without requiring a velocity model. Land environments present several challenges to the inverse scattering series prediction process. This is particularly true for algorithm versions that explicitly account for elastic conversions and incorporate multicomponent data. The theory for elastic reference medium inverse scattering series internal multiple prediction was introduced several decades ago, but no numerical analysis or practical discussion of how to prepare data for it currently exists. We have focused our efforts on addressing this gap. We extend the theory from 2D to 3D, analyze the properties of the input data required by the existing algorithm, and, motivated by earlier research results, reformulate the algorithm in the plane-wave domain. The success of the prediction process relies on the ordering of events in either pseudodepth or vertical traveltime being the same as the ordering of reflecting interfaces in true depth. In elastic-multicomponent cases, it is difficult to ensure that this holds true because the events to be combined may have undergone multiple conversions as they were created. Several variants of the elastic-multicomponent prediction algorithm are introduced and examined for their tendency to violate ordering requirements (and create artifacts). A plane-wave domain prediction, based on elastic data that have been prepared (1) using variable, “best-fit” velocities as reference velocities, and (2) with an analytically determined vertical traveltime stretching formula, is identified as being optimal in the sense of generating artifact-free predictions with relatively small values of the search parameter [Formula: see text], while remaining fully data driven. These analyses are confirmed with simulated data from a layered model; these are the first numerical examples of elastic-multicomponent inverse scattering series internal multiple prediction.
Sparse spectral attributes to detect hydrocarbons: A case study from deep dolomite reservoirs
Authors: Gao Jianhu , Liu Bingyang , Li Shengjun , Wang Hongqiu 
Published: June 2019

Hydrocarbon detection is always one of the most critical sections in geophysical exploration, which plays an important role in subsequent hydrocarbon production. However, due to the low signal-to-noise ratio and weak reflection amplitude of deep seismic data, some conventional methods do not always provide favorable hydrocarbon prediction results. The interesting dolomite reservoirs in Central Sichuan are buried over an average depth of 4500 m, and the dolomite rocks have a low porosity below approximately 4%, which is measured by well-logging data. Furthermore, the dominant system of pores and fractures as well as strong heterogeneity along the lateral and vertical directions lead to some difficulties in describing the reservoir distribution. Spectral decomposition (SD) has become successful in illuminating subsurface features and can also be used to identify potential hydrocarbon reservoirs by detecting low-frequency shadows. However, the current applications for hydrocarbon detection always suffer from low resolution for thin reservoirs, probably due to the influence of the window function and without a prior constraint. To address this issue, we developed sparse inverse SD (SISD) based on the wavelet transform, which involves a sparse constraint of time-frequency spectra. We focus on investigating the applications of sparse spectral attributes derived from SISD to deep marine dolomite hydrocarbon detection from a 3D real seismic data set with an area of approximately [Formula: see text]. We predict and evaluate gas-bearing zones in two target reservoir segments by analyzing and comparing the spectral amplitude responses of relatively high- and low-frequency components. The predicted results indicate that most favorable gas-bearing areas are located near the northeast fault zone in the upper reservoir segment and at the relatively high structural positions in the lower reservoir segment, which are in good agreement with the gas-testing results of three wells in the study area.
Rocking the boat of vitamin D research in schizophrenia and depression
Authors: Tiemeier Henning 
Published: June 2019

SUMMARYA review of studies on vitamin D in schizophrenia and depression found insufficient evidence to inform advice for clinicians. On the basis of the review, I suggest advice for researchers, including better controlling for confounders in observational studies, testing the reverse causality hypothesis, studying vitamin D as a treatment or prevention specifically in patients with more pigmented skin, and prospective community trials of vitamin D supplementation combined with lifestyle advice.DECLARATION OF INTERESTNone.
ANNOUNCE: A randomized, placebo (PBO)-controlled, double-blind, phase (Ph) III trial of doxorubicin (dox) + olaratumab versus dox + PBO in patients (pts) with advanced soft tissue sarcomas (STS).
Authors: Tap William D. , Wagner Andrew J. , Papai Zsuzsanna , Ganjoo Kristen N. , Yen Chueh-Chuan , Schoffski Patrick , Abdul Razak Albiruni Ryan , Martin Broto Javier , Spira Alexander I. , Kawai Akira , Krarup-Hansen Anders , Le Cesne Axel , Van Tine Brian , Naito Yoichi , Park Se Hoon , Soldatenkova Victoria , Mo Gary , Shahir Ashwin , Wright Jennifer , Jones Robin Lewis 
Published: June 2019

LBA3 Background: Dox is standard therapy in STS. In a Ph 2 trial, olaratumab (a human IgG1 antibody targeting PDGFRα) + dox improved overall survival (OS) and progression-free survival (PFS) vs dox. ANNOUNCE aimed to confirm the OS benefit in advanced STS. Methods: Adult pts with unresectable locally advanced or metastatic STS, anthracycline-naïve, and ECOG PS 0-1 were eligible. Pts were randomized 1:1 to olaratumab (20mg/kg Cycle 1, 15mg/kg subsequent cycles) or PBO on Days 1 and 8 of each 21-day cycle combined with dox (75mg/m2) on Day 1 for up to 8 cycles. After 8 cycles, pts with disease control continued olaratumab or PBO until progression or toxicity. Randomization was stratified by histology, prior systemic therapy, ECOG PS, and geographic region. Dexrazoxane use was allowed to mitigate dox-related cardiotoxicity. Primary endpoints were OS in the intent-to-treat (ITT) population and/or leiomyosarcoma (LMS) subset of the ITT population; the study was designed to be positive if either primary endpoint was met. Secondary endpoints included PFS, response/disease control rates, safety, and pharmacokinetics. Results: 509 pts were randomized: 258 in the investigational and 251 in the control arm. Baseline pt characteristics were well balanced. Dexrazoxane was received by 63.0% vs 65.1% of pts (investigational vs control arm, respectively, for all data). In the ITT population, median OS was 20.4 vs 19.8 months (m) (HR=1.05, 95% CI: 0.84-1.30; p = 0.69) and was 21.6 vs 21.9 m in LMS pts (HR=0.95, 95% CI: 0.69-1.31; p = 0.76). Median PFS was lower in the investigational arm in the ITT population (5.4 vs 6.8 m; HR=1.23, 95% CI: 1.01-1.50; p = 0.04) and in LMS pts (4.3 vs 6.9 m, HR=1.22, 95% CI: 0.92-1.63; p = 0.17). Median dox exposure was 6 vs 7 cycles. Safety was similar between arms. Olaratumab serum concentrations reached levels expected from prior trials. Additional subgroup/biomarker results will be presented. Conclusions: ANNOUNCE did not confirm that olaratumab + dox, followed by olaratumab monotherapy, improves OS over dox in pts with advanced STS. Further analyses are warranted to explore the inconsistent outcomes between the Ph 3 and Ph 2 studies. Clinical trial information: NCT02451943.
Budget Impact of Treatment-Free Remission in Treating Chronic-Phase Philadelphia-Positive Chronic Myeloid Leukemia in Lebanon
Authors: Elias Fadia , Gebran Anthony , Said Christina , Beker Russell V. , Ammar Walid 
Published: June 2019

PURPOSE Chronic myeloid leukemia (CML) ranks second in terms of disease-related health care expenditures at the Lebanese Ministry of Public Health (MoPH) after breast cancer. With the introduction of tyrosine kinase inhibitors (TKIs), survival of patients with CML has dramatically improved and approached that of the normal population. In recent years, several studies demonstrated that patients who achieve a deep molecular response while receiving TKI therapy could safely attempt treatment-free remission (TFR), the new treatment goal in patients with CML. The objective is to estimate the budget impact of TFR at the MoPH. METHODS Analyses were done on 162 patients with CML receiving imatinib, nilotinib, or dasatinib, as first-line or second-line therapy, over a 4-year time horizon using MoPH drug pricing. The model assumed that patients could attempt TFR after 36 months of TKI therapy, where the last 24 months were at stable molecular response as per MoPH and National Comprehensive Cancer Network guidelines. Duration of TFR was based on European Stop Kinase Inhibitor treatment-free survival curve. RESULTS Out of the 162 patients, 83 were eligible to attempt TFR, 36 patients were not eligible, 32 patients were lost to follow-up, two patients died as a result of CML progression, and five died as a result of other causes. The total cost of CML treatment with TFR from the time of analysis and over 4 years can be reduced by more than 7 million US dollars (57%). CONCLUSION The model can be used to inform health care decision makers on the importance of TFR and the potential savings.
Preoperative MRI features and clinical laboratory indicators for predicting the early therapeutic response of hepatocellular carcinoma to transcatheter arterial chemoembolization combined with High-intensity focused ultrasound treatment
Authors: Zhang Haiping , He Xiaojing , Yu Jiayi , Song Wenlong , Liu Xinjie , Liu Yangyang , Zhou Jun , Guo Dajing 
Published: June 2019

Objectives:
To evaluate the value of preoperative MRI features and laboratory indicators in predicting the early response of hepatocellular carcinoma (HCC) to transcatheter arterial chemoembolization (TACE) combined with high-intensity focused ultrasound (HIFU) treatment and to establish a preoperative prediction model.

Methods:
A total of 188 patients with 223 tumors who underwent TACE/HIFU treatment from January 2011 to June 2017 were included. Tumors were divided into three groups (&lt; 2 cm, 2 – 5 cm,&gt; 5 cm) and classified as non-complete response (NCR) and complete response (CR) cohorts according to the Response Evaluation Criteria in Cancer of the Liver (RECICL) 2015 revised version. Univariate analysis and multivariate logistic regression analysis were used to determine independent predictors, and receiver operating characteristic (ROC) curve analysis was performed to assess the diagnostic power of each predictor. The prediction model was derived on the β coefficient of the multivariate regression analysis of the predictors.

Results:
Irregular margins in the 2 – 5 cm group were closely related to early NCR. Irregular margins, arterial peritumoral enhancement and abnormal alpha-fetoprotein (AFP) were independent predictors of early NCR in the &gt; 5 cm group. The prediction model of this group suggests that irregular margins combined with arterial peritumoral enhancement and abnormal AFP combined with irregular margins and arterial peritumoral enhancement predict an increased risk of early NCR.

Conclusion:
Irregular margins of 2 – 5 cm tumors and irregular margins, arterial peritumoral enhancement, and abnormal AFP of tumors &gt; 5 cm can be applied to predict the early response of HCC to TACE/HIFU treatment.

Advances in knowledge:
TACE combined with HIFU treatment may be able to significantly improve survival in patients with advanced HCC. Conventional MRI features and laboratory indicators are readily available without complex post-processing. It is feasible to predict the response of HCC after TACE/HIFU treatment based on preoperative conventional MRI features and laboratory indicators, the combination of multiple features predicts high-risk of non-complete response.
Co-Expression Network Analysis Identifies Possible Hub Genes in Aging of the Human Prefrontal Cortex
Authors: Payán-Gómez, MD, MSc, PhD César , Riaño-Moreno, MD, MSc Julián , Amador-Muñoz, MD, MSc Diana , Ramírez-Clavijo, MSc, PhD Sandra 
Published: June 2019

Introduction: Aging is the main risk factor for the development of chronic diseases such as cancer, diabetes, Parkinson’s disease, and Alzheimer’s disease. The central nervous system is particularly susceptible to progressive functional deterioration associated with age, among the brain regions the prefrontal cortex (PFC) has one of the highest involvements. Transcriptomics studies of this brain region have identified the decrease in synaptic function and activation of neuroglia cells as fundamental characteristics of the aging process. The aim of this study was to identify hub genes in the transcriptomic deregulation in the PFC aging to advance in the knowledge of this process. Materials and methods: A gene co-expression analysis was carried out for 45 people 60 to 80 years old compared with 38 people 20 to 40 years old. The networks were visualized and analyzed using Cytoscape; citoHubba was used to determine which genes had the best topological characteristics in the co-expression networks. Results: Five genes with high topological characteristics were identified. Four of them —hpca, cacng3, ca10, plppr4— were repressed and one was over-expressed —Cryab—. Conclusion: The four repressed genes are expressed preferentially in neurons and regulate the synaptic function and the neuronal plasticity, while the overexpressed gene is typical of glial cells and is expressed as a response to neuronal damage, facilitating myelination and neuronal regeneration.
Factores inmunológicos relacionados con VIH-1 en pacientes colombianos
Authors: Marin-Palma, MSc Damariz , Cardona-Arias, MSc Jaiberth A. , Hernández, Sci Doc Juan Carlos 
Published: June 2019

Introducción: los inflamasomas dirigen la maduración de las citoquinas il-1b e il-18, las cuales contribuyen en la patogénesis de la infección por VIH-1. Dada la complejidad de la infección, se hace necesaria la búsqueda de marcadores que permitan identificar nuevos blancos terapéuticos o hacer seguimiento del estado inmunológico de los pacientes. Por lo tanto, el objetivo del presente trabajo fue explorar el efecto independiente los principales componentes inflamatorios sobre la infección por VIH-1. Materiales y métodos: estudio analítico con 36 pacientes vih+ y 36 controles sanos, pareados por edad y sexo. Se cuantificó la carga viral, los linfocitos T cd4+/cd8+, el perfil lipídico, la proteína C reactiva y las concentraciones séricas de il-1β, il-6 e il-18. El MRNA de los genes relacionados con los inflamasomas fue cuantificado por RT-PCR en tiempo real. El análisis estadístico se basó en medidas de resumen, pruebas de hipótesis y regresión logística binaria multivariante. Resultados: se encontraron menores valores de HDL y MRNA il-18 y mayores de MRNA NLRP1 y MRNA ASC en los pacientes con VIH-1, comparados con los controles. Los valores de HDL y MRNA il-18 se correlacionaron con los recuentos de linfocitos. En el análisis multivariado se encontró que la relación cd4/cd8, el MRNA il-18 y el MRNA ASC pueden constituir las principales variables que tienen un potencial explicativo sobre la infección por VIH-1 en la población de estudio. Conclusión: se evidenció la importancia de estudiar los inflamasomas, dado que en la población de estudio constituyen potenciales blancos terapéuticos para disminuir la respuesta inflamatoria.
Efectividad analgésica del clonixinato de lisina asociado con el paracetamol en el tratamiento posoperatorio de exodoncias
Authors: Bacilio Amaranto, DD Reyma Evelyn , Millones Gómez, PhD Pablo Alejandro 
Published: June 2019

Introducción: el uso de terapias analgésicas para controlar el dolor postexodoncia es muy variado y depende muchos factores. El objetivo de este estudio fue comparar la efectividad analgésica del paracetamol asociado con el clonixinato de lisina y compararlo con monoterapias de paracetamol e ibuprofeno en el tratamiento posoperatorio de exodoncias. Materiales y métodos: la muestra estuvo conformada por 39 pacientes distribuidos aleatoriamente en tres grupos. El dolor posoperatorio se midió utilizando la Escala Visual Análoga (EVA) 1 h, 8 h y 24 h postexodoncia. El análisis estadístico de la evolución de las tres terapias, se realizó empleando el test t de Student, anova y test de Tuckey, con un nivel de significancia de p < 0.05. Resultados: los valores obtenidos demostraron que la combinación analgésica de paracetamol asociado con el clonixinato de lisina fue más efectiva 1 h y 8 h después. A las 24 h no existieron diferencias en los tres grupos de estudio. Conclusión: la analgesia de la terapia combinada de Paracetamol asociada con el Clonixinato de lisina es superior a la producida por la dosis estándar de Ibuprofeno y Paracetamol en el tratamiento del dolor posoperatorio de exodoncias simples.
Análisis histórico epidemiológico de la pandemia de gripa de 1918-1919 en Boyacá, un siglo después
Authors: Martínez Martín, PhD Abel Fernando , Meléndez Álvar Bernardo Francisco Andrés , Manrique Corredor, PhD Edwar Javier , Robayo Avendaño, PhD Omar Fernando 
Published: June 2019

Introducción: la gripa que ocurrió entre 1918-1919 causó la mayor mortalidad en la historia de las pandemias, se estima que 50 millones de personas fallecieron. Se realizó un estudio históricoepidemiológico a partir de fuentes documentales contrastadas con un análisis estadístico de 142 963 registros de defunción consignados en los libros parroquiales de 94 municipios de Boyacá y los censos de los años 1912, 1918 y 1928. Desarrollo: a partir de las fuentes primarias obtenidas, se reconstruye la realidad socio-sanitaria de Boyacá y el desarrollo cronológico de la pandemia en el departamento. La gripa era conocida en Boyacá antes de la pandemia. Durante el periodo pandémico (1918-1919) se encontraron 20 102 decesos en los libros parroquiales, 3305 registrados como gripa, de los cuales el 80.9 % ocurrieron en los últimos 3 meses de 1918, siendo los menores de 4 años el grupo poblacional más afectado. Conclusiones: después de la pandemia, la gripa se hace endémica en Boyacá. En el periodo pandémico, la tasa promedio de mortalidad en los municipios ubicados sobre los 2000 msnm es tres veces mayor a aquellos que se encuentran por debajo de esta altura. Las condiciones de pobreza y hacinamiento acentuaron la letalidad de la pandemia, por lo que fueron ineficientes las acciones de las direcciones de higiene para enfrentarla. Las juntas de socorros y la Junta Patriótica de Sanidad son las únicas que realizaron acciones efectivas.
Focused shockwave therapy in diabetic foot ulcers: secondary endpoints of two multicentre randomised controlled trials
Authors: Galiano Robert , Snyder Robert , Mayer Perry , Rogers Lee C. , Alvarez Oscar ,   The Sanuwave Trial Investigators
Published: June 2019

Objective: The objective of this paper is to present the secondary safety and efficacy outcomes from two studies of focused extracorporeal shockwave therapy (ESWT) used adjunctively with standard care in the treatment of neuropathic diabetic foot ulcers (DFU) (1A or 2A on the University of Texas grading scheme), compared with sham treatment and standard care. Method: We carried out two multicentre, multinational, randomised, sham-controlled, double-blinded, phase III clinical studies using standard care with adjunctive focused ESWT compared with sham treatment and standard care in patients with a DFU. DFUs that did not reduce in volume by at least 50% over two weeks' standard treatment were included. DFUs were randomised and managed with standard care and focused ESWT (pulsed acoustic cellular expression; dermaPACE System, SANUWAVE Health, Inc.) active therapy, or with standard care and sham treatment, four times over a two-week treatment phase in study 1 and up to eight times over 12 weeks in study 2. Standard care continued in both studies throughout the 12-week treatment phase. Secondary outcomes were indicators of wound closure and progression, pain, infection, amputation and recurrence, and device reliability. Efficacy-related secondary endpoints were measured at 12, 20 and 24 weeks. The studies were analysed separately and following statistical comparison to justify the method, as a pooled data set. Results: Wound area reduction (48.6% versus 10.7%, p=0.015, intention to treat (ITT) population with last observation carried forward (LOCF)) and perimeter reduction (46.4% versus 25.0%, p=0.022, ITT population with LOCF) were significantly greater in the active therapy group compared with the sham-treated group, respectively. The difference in time to wound closure in the pooled ITT population was significantly in favour of the active therapy group (84 days versus 112 days for 25% of subjects to reach wound closure in the active and sham-treated groups, respectively; p=0.0346). The proportion of subjects who achieved wound area reduction (WAR) from baseline at week 12 of ≥90% was significantly higher in the active therapy group. The incidence and nature of infection were consistent with previously published studies, and pain was not increased in the active therapy group. Amputation was insignificantly higher in the sham-treated group and recurrence did not differ. The ESWT device was found to be reliable. Conclusion: The outcomes for the primary and secondary endpoints from these studies show that ESWT administered adjunctively with standard care is an effective advanced therapy for neuropathic DFUs (grade 1A and 2A) that do not respond to two weeks' standard care alone by reducing wound volume by at least 50%.
Was it a strike? Notes on the Polish Women’s Strike and the Strike of Parents of Persons with Disabilities.
Authors: Kubisa Julia , Rakowska Katarzyna 
Published: June 2019

Dwa znaczące protesty społeczne, które miały miejsce w Polsce w ostatnich latach – masowa mobilizacja kobiet przeciwko zakazowi aborcji i okupacja budynku Sejmu przez opiekunów osób niepełnosprawnych – nazywano strajkami. W artykule analizujemy wydarzenia związane ze Strajkiem Kobiet w 2016, 2017 i 2018 roku oraz strajk Rodziców Osób Niepełnosprawnych z 2018 roku, ujmując strajk jako formę protestu. Dlaczego obydwa protesty nazwano strajkami i jakie są implikacje określania ich przy użyciu terminologii z zakresu sporów zbiorowych? W Polsce strajki są formą zbiorowego, zinstytucjonalizowanego konfliktu pracowników najemnych, organizowanego wyłącznie przez związek zawodowy zarejestrowany w określonym miejscu pracy, a ich przedmiotem mogą być wyłącznie sprawy związane z miejscem pracy, nie zaś sprawy polityczne i znajdujące się poza gestią pracodawcy. Strajk Kobiet i protest Rodziców Osób Niepełnosprawnych nie były strajkami de iure, odrzucały jednak podział na produkcję (pracę najemną) i reprodukcję (praca nieodpłatna), co nadało szczególne znaczenie „odmowie pracy”, jaka miała wówczas miejsce. Użycie koncepcji strajku i stworzenie przestrzeni łączącej różne działania związane z walkami o prawa pracownicze i reprodukcyjne skutkowało upodmiotowieniem protestujących. Interpretujemy to jako strategię przejęcia typowych akcji protestacyjnych zarezerwowanych wcześniej dla pracowników najemnych.