bluuebunny/crossref_metadata_2025_split huggingface dataset:
Client, provider and community referrer perceptions of telehealth for the delivery of rural paediatric allied health services
Authors: Campbell Jessica , Theodoros Deborah , Russell Trevor , Gillespie Nicole , Hartley Nicole 
Published: October 2019

AbstractObjectiveTo examine allied health client, provider and community referrer perceptions of telehealth for the delivery of rural paediatric allied health services to facilitate adoption.DesignA qualitative design employed semistructured interviews with the three key stakeholder groups.SettingStakeholders were associated with BUSHkids (The Royal Queensland Bush Children's Health Scheme), a not‐for‐profit organisation serving children and families in Queensland, Australia.ParticipantsThirty‐nine stakeholders (12 clients, 16 providers and 11 community referrers).Main outcome measuresParticipants were asked about familiarity with telehealth, willingness to use telehealth and perceived barriers and facilitators to telehealth acceptability.ResultFifty‐nine percent of participants had experienced telehealth and 77 percent were willing to use it. Participants perceived that technology problems were a barrier to telehealth, that children would not be able to concentrate on or enjoy telehealth sessions, that relationships and communication would be inferior to in‐person sessions, and that telehealth was inappropriate for disciplines employing physical touch. Participants identified access to health services as a key benefit of telehealth, said that technology problems could be worked around, and said that telehealth services could be supported with internal partners (eg, assistants) and external partners (eg, local medical centres). They also identified a variety of telehealth benefits to families (eg, convenience, privacy).ConclusionOverall, telehealth was acceptable to stakeholders. Providers need training to facilitate child participation online and identify alternatives to physical touch. Co‐learning opportunities should be used to address low provider and referrer self‐efficacy.
Be your product
Authors: HARDON ANITA , DAVATOS IAN ANTHONY B. , LASCO GIDEON 
Published: October 2019

ABSTRACTYoung people in Puerto Princesa, the Philippines, are drawn to working as salespeople for AIM Global, a purveyor of the nutritional supplement C24/7. The company relies on multilevel marketing, in which sellers recruit other sellers, offering youth not only the chance to earn money but also educational discounts, access to bank cards, and an opportunity to develop do‐it‐yourself entrepreneurial skills. Trainers encourage sellers to capitalize on their intimate relations, to tailor the supplements to assuage aging clients’ metabolic‐health anxieties, and to use C24/7 themselves so that they can testify to its benefits. Such “sociometabolic” work is omnipresent in urban settings, where workers in beauty salons and gyms likewise promise to mitigate the material, bodily disturbances caused by toxic environments and precarious living conditions. [multilevel marketing, youth, sociometabolic labor, relational work, aspirations, nutritional supplements, metabolic health, ecology, Philippines]
Precarious Territory: Property Law, Housing, and the Socio‐Spatial Order
Authors: Blomley Nicholas 
Published: October 2019

AbstractMost of us access shelter over land over which other people have legally sanctioned dominant interests and powers, creating systemic relations of security and vulnerability that I term precarious property. We all live inside the territory of property, but do so under different terms. Rather than thinking of the territory of property as an exclusive space of insiders and outsiders, I think of it as a relational technology that organises forms of conditional spatial access. Territorialised expressions of law play a crucial role in organising such relations through a “property space” that frames property’s participants, their interactions, their alternatives to transacting, and the meanings of property itself. Thinking territorially about precarious property offers us both analytical and ethico‐political insights, I suggest.
Optimizing the decellularization process of an upper limb skeletal muscle; implications for muscle tissue engineering
Authors: Naik Anish , Griffin Michelle , Szarko Matthew , Butler Peter E 
Published: October 2019

AbstractUpper limb muscle reconstruction is required following cancer resection, trauma, and congenital deformities. Current surgical reconstruction of the muscle involves local, regional and free flaps. However, muscle reconstruction is not always possible due to the size of the defect and functional donor site morbidity. These challenges could be addressed with the production of scaffolds composed of an extracellular matrix (ECM) derived from decellularized human skeletal muscle. This study aimed to find an optimal technique to decellularize a flexor digitorum superficialis muscle. The first two protocols were based on a detergent only (DOT) and a detergent‐enzymatic protocol (DET). The third protocol avoided the use of detergents and proteolytic enzymes (NDNET). The decellularized scaffolds were characterized using qualitative techniques including histological and immunofluorescent staining and quantitative techniques assessing deoxyribonucleic acid (DNA), glycosaminoglycan (GAG), and collagen content. The DOT protocol consisting of 2% SDS for 4 hours was successful at decellularizing human FDS, as shown by DNA content assay and nuclei immunofluorescence staining. The DOT protocol maintained the microstructure of the scaffolds as shown by Masson’s trichrome staining and collagen and GAG content. DET and NDNET protocols maintained the ECM, but were unsuccessful in removing all DNA content after two cycles of decellularization. Decellularization of skeletal muscle is a viable option for muscle reconstruction using a detergent only technique for upper limb defects. Further testing in vivo will assess the effectiveness of decellularized scaffolds for upper limb muscle skeletal tissue engineering.
An 8‐Week Relaxation Program Consisting of Progressive Muscle Relaxation and Mindfulness Meditation to Reduce Stress and Attenuate Stress‐Driven Eating
Authors: Masih Tasmiah , Dimmock James A. , Epel Elissa , Guelfi Kym J. 
Published: October 2019

BackgroundStress is often associated with the intake of energy‐dense palatable foods. This trial examined the feasibility and preliminary efficacy of an 8‐week worksite‐based relaxation intervention to address psychological stress and unhealthy food intake.MethodsThirty‐six men and women were exposed to an acute stressor, while physiological and psychological responses were assessed, prior to being offered a test meal. Participants were then randomised to a relaxation intervention (RELAX; face‐to‐face classes and daily home practice of progressive muscle relaxation and mindfulness meditation), or a wait‐list control (CON). All measures were repeated after the intervention.ResultsIntervention compliance was high (80% ± 19% face‐to‐face; 79% ± 18% home practice), and each session acutely reduced perceived stress (p < .001) and increased relaxation (p < .001). After 8 weeks, trait mindfulness was increased (p = .025), along with reduced tension (p = .013) and increased relaxation (p < .05) post‐acute stressor in the intervention group. There was no effect of the intervention on palatable eating, cravings, or energy intake at a laboratory test meal, with small associated effect sizes (d = 0.01–0.3).ConclusionsThe program studied here is feasible and sessions transiently reduce perceived stress and improve mindfulness; however, the program may not influence the physiological response to an acute stressor or appetite and eating variables.
Correlation between orthopaedic and radiographic examination findings and arthroscopic ligament fibre damage in dogs with cruciate ligament rupture
Authors: Ashour AE , Hoffman CL , Muir P 
Published: October 2019

ObjectiveThe objective is to study the correlations between physical examination and stifle radiography findings and severity of arthroscopic cranial cruciate ligament (CrCL) fibre damage in dogs with cruciate rupture (CR).DesignDesign Prospective clinical study.MethodsTwenty‐nine client‐owned dogs with CR underwent physical examination, stifle radiography and arthroscopy, and the findings were recorded. Initial examination was repeated after sedation and after general anaesthesia. The Spearman rank correlations of examination variables with diagnostic imaging were examined.ResultsOverall, cranial tibial translation assessed by the tibial compression test in extension showed correlation with arthroscopic CrCL fibre damage (P < 0.05). Correlations between severity of cranial drawer laxity and arthroscopic CrCL fibre damage were not significant. Under general anaesthesia, stifle laxity tests were positively correlated with lameness severity grade (SR ≥ 0.41, P < 0.05). Meniscal damage was correlated with pain on the internal rotation of the tibia (SR= 0.42, P<0.05) and severity of radiographic osteophytosis (SR= 0.53, P = 0.01).ConclusionDetection and estimation of severity of cranial tibial translation enable the diagnosis of CR and also the inference of the severity of CrCL fibre rupture, particularly with the tibial compression test in extension. Severity of joint laxity is best assessed under general anaesthesia. Such knowledge should reduce the risk of misdiagnosis and may enhance early diagnosis and treatment of dogs with CR over time.
Trajectory patterns of academic engagement among elementary school students: The implicit theory of intelligence and academic self‐efficacy matters
Authors: Zhen Rui , Liu Ru‐De , Wang Ming‐Te , Ding Yi , Jiang Ronghuan , Fu Xinchen , Sun Yan 
Published: October 2019

BackgroundThe dropout rate of Chinese elementary school students after 2007 rose again. Little research to date has identified individual differences in pathways of academic engagement to discern those at risk of disengagement and dropout from schools, as well as the longitudinal linkages between cognitive beliefs with academic engagement.AimsExamine the developmental trajectories of cognitive, emotional, and behavioural engagement, and assess relations between the implicit theory of intelligence and academic self‐efficacy and the development of academic engagement.Sample and methodsWe recruited 532, 450, and 415 elementary students to rate on self‐report scales in April 2016 (T1), October 2016 (T2), and April 2017 (T3), respectively. Trajectories of academic engagement were analysed by using a multiple‐process growth mixture model, and levels of entity theory of intelligence and academic self‐efficacy between engagement groups were compared by using analysis of variance.ResultsWe categorized the students into four groups: persistent (71.24%), climbing (6.01%), descending (16.54%), and struggling engagement (6.20%) groups. Within each group, the levels of academic self‐efficacy from T1 to T3 demonstrated a consistent trend with the engagement trajectory; the levels of the implicit theory of intelligence over time showed the reverse trend.ConclusionsAttention should be given more on the students from the descending and struggling groups. The implicit theory of intelligence and academic self‐efficacy showed different longitudinal associations with engagement trajectories.
Pre‐ and post‐serial metagenomic analysis of gut microbiota as a prognostic factor in patients undergoing haematopoietic stem cell transplantation
Authors: Kusakabe Shinsuke , Fukushima Kentaro , Maeda Tetsuo , Motooka Daisuke , Nakamura Shota , Fujita Jiro , Yokota Takafumi , Shibayama Hirohiko , Oritani Kenji , Kanakura Yuzuru 
Published: October 2019

SummaryThe human gut harbours diverse microorganisms, and gut dysbiosis has recently attracted attention because of its possible involvement in various diseases. In particular, the lack of diversity in the gut microbiota has been associated with complications of haematopoietic stem cell transplantation (HSCT), such as infections, acute graft‐versus‐host disease and relapse of primary disease, which lead to a poor prognosis. However, few studies have serially examined the composition of the intestinal microbiota after HSCT. In this study, we demonstrated, using next‐generation sequencing of the bacterial 16S ribosomal RNA gene, combined with uniFrac distance analysis, that the intestinal microbiota of patients undergoing allogeneic HSCT substantially differed from that of healthy controls and recipients of autologous transplants. Faecal samples were obtained daily throughout the clinical course, before and after transplantation. Notably, the proportions of Bifidobacterium and genera categorized as butyrate‐producing bacteria were significantly lower in patients with allogeneic HSCT than in healthy controls. Furthermore, among allogeneic transplant recipients, a subgroup with a preserved microbiota composition showed a benign course, whereas patients with a skewed microbiota showed a high frequency of complications and mortality after transplantation. Thus, we conclude that the stability of intestinal microbiota is critically involved in outcomes of HSCT.
How we manage adults with myelodysplastic syndrome
Authors: Fenaux Pierre , Platzbecker Uwe , Ades Lionel 
Published: October 2019

SummaryThe prognosis in Myelodysplastic syndromes (MDS), although recently refined by molecular studies, remains largely based on conventional prognostic scores [International Prognostic Scoring System (IPSS), revised IPSS], classifying patients into “lower risk” MDS (LR‐MDS) and “higher risk” MDS (HR‐MDS). In LR‐MDS, treatment mainly aims at improving cytopenias, principally anaemia, while in HR‐MDS it aims at delaying disease progression and prolonging survival. In LR‐MDS without deletion 5q, anaemia is generally treated first by erythropoietic stimulating factors, while second line treatments are currently not approved [lenalidomide, hypomethylating agents (HMA), luspatercept] or rarely indicated (antithymocyte globulin). Lenalidomide has major efficacy in LR‐MDS with deletion 5q. Allogeneic stem cell transplantation (allo‐SCT) is sometimes considered in LR‐MDS, and iron chelation can be considered when multiple red blood cell transfusions are required. Allo‐SCT is the only potentially curative treatment for HR‐MDS; however, it is rarely applicable. It is generally preceded by intensive chemotherapy (IC) or HMA in patients with excess of marrow blasts (especially if >10%). In other patients, HMA can improve survival. The role of new drugs, including venetoclax or, in case of specific mutations, IDH1 or IDH2 inhibitors, is investigated. IC is mainly indicated as a bridge to allo‐SCT, in the absence of unfavourable karyotype.
Safety of switching from intravenous to subcutaneous rituximab during first‐line treatment of patients with non‐Hodgkin lymphoma: the Spanish population of the MabRella study
Authors: García‐Muñoz Ricardo , Quero Cristina , Pérez‐Persona Ernesto , Domingo‐García Abel , Pérez‐López Cristina , Villaescusa‐de‐la‐Rosa Teresa , Martínez‐Castro Ana M. , Arguiñano‐Pérez José M. , Parra‐Cuadrado Juan F. , Panizo Carlos 
Published: October 2019

SummaryRituximab is a standard treatment for non‐Hodgkin diffuse large B‐cell (DLBCL) and follicular (FL) lymphomas. A subcutaneous formulation was developed to improve the resource use of intravenous rituximab, with comparable efficacy and safety profiles except for increased administration‐related reactions (ARRs). MabRella was a phase IIIb trial to assess the safety of switching from intravenous to subcutaneous administration of rituximab during first‐line induction/maintenance for DLBCL or FL, focusing on ARRs. Efficacy, satisfaction and quality of life were also assessed. Patients received subcutaneous rituximab plus standard induction chemotherapy for DLBCL or FL for 4–7 cycles, and/or every 2 months maintenance monotherapy for FL for 6–12 cycles. The study included 140 patients: DLBCL, n = 29; FL, n = 111. Ninety‐five percent of patients experienced adverse events, reaching grade ≥3 in 38·6% and were serious in 30·0%. AARs occurred in 48·6%, mostly (84·9%) at the injection site, with only 2·1% of patients reaching grade 3. The end‐of‐induction complete/unconfirmed complete response rate was 69·6%. After a median follow‐up of 33·5 months, median disease‐/event‐/progression‐free and overall survivals were not attained. The Rituximab Administration Satisfaction Questionnaire showed improvements in overall satisfaction and the EuroQoL‐5D a good quality‐of‐life perception at induction/maintenance end. Therefore, switching to subcutaneous rituximab showed no new safety issues and maintained efficacy with improved satisfaction and quality of life.
Efficacy of the NCCV Cocktail‐1 vaccine for refractory pediatric solid tumors: A phase I clinical trial
Authors: Akazawa Yu , Hosono Ako , Yoshikawa Toshiaki , Kaneda Hide , Nitani Chika , Hara Junichi , Kinoshita Yoshiaki , Kohashi Kenichi , Manabe Atsushi , Fukutani Miki , Wakabayashi Masashi , Sato Akihiro , Shoda Kayoko , Shimomura Manami , Mizuno Shoichi , Nakamoto Yasunari , Nakatsura Tetsuya 
Published: October 2019

AbstractPediatric refractory solid tumors are aggressive malignant diseases, resulting in an extremely poor prognosis. KOC1, FOXM1, and KIF20A are cancer antigens that could be ideal targets for anticancer immunotherapy against pediatric refractory solid tumors with positive expression for these antigens. This nonrandomized, open‐label, phase I clinical trial evaluated the safety and efficacy of the NCCV Cocktail‐1 vaccine, which is a cocktail of cancer peptides derived from KOC1, FOXM1, and KIF20A, in patients with pediatric refractory solid tumors. Twelve patients with refractory pediatric solid tumors underwent NCCV Cocktail‐1 vaccination weekly by intradermal injections. The primary endpoint was the safety of the NCCV Cocktail‐1 vaccination, and the secondary endpoints were the immune response, as measured by interferon‐r enzyme‐linked immunospot assay, and the clinical outcomes including tumor response and progression‐free survival. The NCCV Cocktail‐1 vaccine was well tolerated. The clinical response of this trial showed that 4 patients had stable disease after 8 weeks and 2 patients maintained remission for >11 months. In 4, 8, and 5 patients, the NCCV Cocktail‐1 vaccine induced the sufficient number of peptide‐specific CTLs for KOC1, FOXM1, and KIF20A, respectively. Patients with high peptide‐specific CTL frequencies for KOC1, FOXM1, and KIF20A had better progression‐free survival than those with low frequencies. The findings of this clinical trial showed that the NCCV Cocktail‐1 vaccine could be a novel therapeutic strategy, with adequate effects against pediatric refractory solid tumors. Future large‐scale trials should evaluate the efficacy of the NCCV Cocktail‐1 vaccination.
Synthesis, activity, and molecular modeling studies of 1,2,3‐triazole derivatives from natural phenylpropanoids as new trypanocidal agents
Authors: de Souza Thiago Belarmino , Caldas Ivo Santana , Paula Favero Reisdorfer , Rodrigues Camila Coelho , Carvalho Diogo Teixeira , Dias Danielle Ferreira 
Published: October 2019

AbstractThe search for compounds with new structural scaffolds is an important tool to the discovery of new drugs against Chagas disease. We report herein the synthesis of 1,2,3‐triazoles obtained from eugenol and di‐hydroeugenol and their in vitro and in vivo trypanocidal activity. These derivatives were obtained by a three‐step objective route and were suitably characterized by 1H and 13C nuclear magnetic resonance spectroscopy and high‐resolution mass spectrometry. Two compounds (9 and 10) showed activity against epimastigote forms of Trypanosoma cruzi (Y strain) in the range 42.8–88.4 μM and were weakly toxic to cardiomyoblast cells (H9c2 cells). The triazole 10 was the most active derivative and could reduce more than 50% of parasitemia after a 100‐mg/kg oral treatment of mice infected with T. cruzi. Molecular docking studies suggested this compound could act as a trypanocidal agent by inhibiting cruzain, an essential enzyme for T. cruzi metabolism, usually inhibited by triazole compounds.
Responding to the Impacts of the Climate Crisis on Children and Youth
Authors: Sanson Ann V. , Van Hoorn Judith , Burke Susie E. L. 
Published: October 2019

AbstractClimate change poses an urgent threat to future generations. Children are more susceptible to its effects than adults, with immediate and lifelong impacts on their physical and mental health. In addition to having direct experiences of climate impacts, children and youth respond psychologically in troubling ways to their awareness of the climate crisis. Children’s and youth’s needs for support vary across contexts. Climate impacts are generally greater in the developing world (despite the fact that people there are less responsible for causing the crisis), where capacity to prepare for and adapt to the effects is weaker. Hence, we need urgent action on both mitigating climate change and adapting to its impacts. In doing this work, we must acknowledge and build the agency and engagement of children and youth, which also builds resiliency and hope. Although many programs are encouraging, they fail to reach all children in need and are limited in terms of evaluation. Experts in child development can help fill these gaps. In the developed world, few studies address how to support young people in face of their feelings regarding climate change. Listening and providing opportunities for active engagement are among the ways adults can help young people cope, and build a sense of efficacy and a capacity to tackle the crisis and adapt to climate impacts. The upsurge in school strikes for climate action demonstrates young people’s deep concerns about their future and their determination to prevent a climate catastrophe. The climate change crisis raises questions about how professionals committed to the well‐being of the next generation should respond—business as usual is no longer an option, and many valuable ways exist to help ensure that children can thrive on a livable planet.
Beyond the Nuclear Family: Children’s Social Networks and Depressive Symptomology
Authors: Manalel Jasmine A. , Antonucci Toni C. 
Published: October 2019

This study identified social network profiles among children, determined whether profiles vary across sociodemographic characteristics, and investigated links between childhood profiles and depressive symptomology using three waves of data spanning 23 years (Wave 1, 1992 Metro‐Detroit representative sample: n = 193, ages 8–12). Latent profile analysis revealed three profiles: Close Family (22%), Varied Family (57%), Friend and Family (21%). White children were more likely than Black children to be in the Friend and Family profile. Children in the Close Family profile reported the lowest levels of depressive symptomology in childhood, but exhibited the steepest increase over time. Findings suggest that close, family centric networks are protective in childhood, but less so as children develop into adulthood, highlighting the importance of considering developmental perspectives.