bluuebunny/crossref_metadata_2025_split huggingface dataset:
Successful Secondary Reconstruction and Dental Rehabilitation for a Maxillary Bone Defect with Discontinuity after Partial Maxillectomy: A case report
Authors: Park Ji Song , Choi Sunyoung , Myoung Hoon , Han Jeong Joon 
Published: November 2024

ABSTRACT
Secondary reconstruction of the maxillary defect with discontinuity after partial maxillectomy is extremely challenging due to extensive, severe adhesions between the maxillary sinus membrane and oral mucosa, resulting in no space for the grafted bone and a lack of soft tissue to cover the graft. This case reports a 23-year-old female patient who underwent secondary reconstruction for a bone defect caused by a partial maxillectomy to remove an ameloblastoma that had invaded the maxillary sinus. We incised the existing soft tissue ridge at the bone defect and extensive adhesions below the maxillary sinus to create space for the grafted bone and to form an adequate buccal flap. To ensure the grafted bone’s stability and to support the surrounding soft tissues, a cortical bone from the iliac crest was placed beneath the sinus membrane, with cancellous bone grafted underneath, and a titanium mesh was applied at the alveolar region. This approach allowed robust bone regeneration at the graft site, demonstrating dense, well-integrated new bone formation that facilitated successful implant treatment with good primary stability for two implants. This surgical approach, when indicated, can be less invasive than vascularized bone grafts.
Environmental Health and Transportation: A Landscape Design of a Vital Healthy Area in An Ecological Town
Authors: Abderrahmane* MAACHOU 
Published: November 2024

Traveling long distances for specialized treatment causes physical and finanacial coasts. In return, convenient and rapid train transportation along scenic routes provides a suitable atmosphere for recovery in therapeutic health environments. Just a traveling by train saves time andcontributes to economicdevelopment and facilitaiting trade exchanges, aswell as stimulating the economic mobility of regions. Designing a train trajectory thatis not considered from an ecological perspective leads to damage to users and sometimes harms to population Through this research , the ecological space of high speed train station and a parking area on Motorway designed using biomimetics in a healthy area of OuzeraTown in order to avoid the damage resulting from carbon dioxide emissions which provides an appropriate therapeutic environment that provides rapid transportation and specialized healthcare sevices in natural landscape and optimal therapeutic atmosphere in One Health environment.
Is depression a vague concept in psychiatry?
Authors: Boissard Elodie 
Published: November 2024

In this paper I investigate whether "depression" is a vague concept in psychiatry and the consequence of this for philosophers who would like to contribute to the elaboration of an objective definition of it. Assuming that this concept aims at referring to a mental disorder, I show that the current definition of "depression" is controverted: we lack a unified scientific model of it, so a consensual objective definition of it. Actually there is its clinical definition in the nosology but this definition consisting in a list of criteria is accused of being unsufficient to draw a sharp limit between normal and pathological cases. Hence vague boundaries of the extension of the concept as referring to a mental disorder. Moreover its clinical criteria, as descriptive and non distinctive, need to be interpreted by clinicians in a way that remains implicit and contextually variable, and they can apply to completely different clinical pictures. I interpret this as a variability of the descriptive definition of "depression", so that its conditions of use depend on the context: it may apply to two cases that have nothing in common except similarities. Applying the famous wittgensteinien characterization of the concept of "game" to "depression", I argue that this vagueness can be interpreted as showing that "depression" works as cluster of concepts whose instances only share "family resemblances". From this philosophical interpretation I draw the conclusion that the "vagueness problem" of depression at a theoretical level does not make the use of this concept problematic, since this in practice use is always related to a context conferring a specific meaning to the concept. I conclude that philosophers should not look in the clinical sciences for an objective definition of depression as a list of necessary and sufficient conditions pointing at its essence: they should rather either describe the family resemblances between the different versions of this concept, or try to stipulate a definition providing it sharp boundaries. A stipulative definition would be motivated by a pragmatic purpose while not delegitimizing other uses that could be made of the concept. Such a purpose could be to target only medically relevant conditions; actually such conditions do not necessarily have to be conceived of as conditions where there is a disease understood as pathological process that we could objectively define, but they can be seen as conditions that we have medical means to take care of with more benefits than disadvantages.
La ética y la responsabilidad en la implementación de la Inteligencia Artificial: Revisión sistemática.
Authors: Guzman Brand Victor Alfonso , Gelvez Garcia Laura Esperanza 
Published: November 2024

El objetivo de esta investigación es comprender el valor de la ética en la implementación de la inteligencia artificial (IA) en diversas áreas de la sociedad. Se llevó a cabo una revisión sistemática de artículos científicos publicados en bases de datos especializadas, con el fin de identificar principios éticos que aseguren un uso responsable de esta tecnología y contribuyan al desarrollo que beneficie a la sociedad. Resultados: la creciente influencia de la IA en diversas áreas de la vida humana plantea serias dudas sobre la naturaleza y aplicación de nuestros estándares éticos. Durante su desarrollo e implementación, es fundamental considerar una serie de principios para garantizar su uso responsable y propósitos beneficiosos para la comunidad. Discusión: es imperativo que los países establezcan códigos éticos específicos que aborden diversos aspectos críticos. Estas normas deberían centrarse en prevenir el fraude en el desarrollo y usabilidad de las herramientas tecnológicas, así como en evitar el surgimiento de monopolios en los sectores comercial y laboral. Conclusiones: los avances acelerados en este ámbito traen consigo no solo cambios tecnológicos significativos, sino también importantes cuestiones éticas y morales. En este contexto, la reflexión ética se vuelve fundamental para asegurar el desarrollo responsable de estas tecnologías.
Seismic-attribute-driven analysis of an ultra-deep carbonate reservoir: Middle Cambrian to Middle Ordovician strata, north-central Tarim Basin, northwest China
Authors: Dong Xinyu , Hampson Gary J. , Lonergan Lidia , Wang Yanghua 
Published: November 2024

ABSTRACT
We use 3-D seismic data from an unnamed oilfield to characterize the internal architecture, structure, and porosity and permeability distributions in ultra-deep (&gt; 6 km) Cambro-Ordovician carbonate reservoir strata deposited on a long-lived, regionally extensive carbonate platform in the Tarim Basin, northwest China. These strata comprise three dominant seismic facies: 1) tabular, layered units of subparallel to parallel, continuous reflections of medium to high amplitude (SPMAC facies), 2) mounds and lenses of chaotic to subparallel reflections of low to medium amplitude (CPLAD facies), which are widespread in certain stratigraphic levels, and 3) tabular, layered units of parallel, highly continuous reflections of very high amplitude (PVHAC facies). SPMAC facies represents low-energy lagoonal mudstones and wackestones, CPLAD facies represents bioclastic packstones, grainstones, and boundstones in reef–shoal complexes, and PVHAC facies represents alternating gypsum, dolomite, and wackestone–packstone lithologies in the lower part of the reservoir, and the top-reservoir contact between siliciclastic mudstones and packstones–grainstones. Seismic dip-magnitude and time–thickness maps show that CPLAD facies mounds and lenses are present in the middle to uppermost reservoir strata, and are associated with folded intervening and overlying SPMAC and PVHAC facies strata. Differential compaction folded these strata. A fourth, minor seismic facies, BPHAD facies, is recognized by parallel, laterally discontinuous, high-amplitude reflections that are stacked vertically and define rugby-ball-shaped beads, strings of beads, and subvertical cylinders. BPHAD facies is present in two settings. First, as multiple beads scattered within SPMAC and CPLAD facies strata. Here, we interpret them to represent widespread, small-scale reef–shoal complexes (&lt; 500 m across) or collapsed karst caves. Second, BPHAD facies is present as strings of beads and subvertical cylinders near bends in strike-slip faults. We interpret these strings of beads and subvertical cylinders to be hypogene karst formed by hydrothermal fluids. This study predicts reservoir permeability and porosity with improved understanding of stratigraphic architecture in the Tarim Basin.
Uncertainty Quantification Based on Deep-Learning Approach Integrating Time-Lapse Seismic Data for Geological Carbon Storage
Authors: Kim Hyunmin , Shin Hyundon , Jo Honggeun 
Published: November 2024

Abstract
Carbon capture and storage (CCS) is a crucial technology for reducing greenhouse gas emissions to achieve net-zero goals by 2050. Reasonable assessment of CO2 plume behavior through reliable subsurface characterization and continuous monitoring (e.g., time-lapse seismic) is a prerequisite for the successful implementation CCS. However, the scarcity of data acquisition and the high degree of error during seismic inversion have hindered successful subsurface characterization and monitoring for CCS in many previous attempts. In this study, we propose a novel workflow that integrates time-lapse seismic data into subsurface model characterization with the assistance of deep learning. The suggested workflow demonstrates enhanced reservoir characterization performance and accurate prediction of future CO2 plume behavior. The study consists of three main components: (1) a seismic forward model, which generates synthetic time-lapse seismic data from relevant acoustic attributes such as porosity, density, and P-wave velocity; (2) a deep learning model based on generative adversarial networks (GANs), which inputs seismic data and outputs porosity and facies properties; and (3) a demonstration of the workflow in an anticline saline aquifer. By integrating initial and 5 years postinjection seismic data, the proposed workflow enables the creation of a more accurate ensemble of subsurface models compared to the initial ensemble. This approach effectively handles multiple possible geological scenarios and added noise in the seismic data, resulting in better predictions of future CO2 plume behavior.
Adherence to Life's Essential 8 is associated with reduced all-cause and cause-specific mortality in individuals with metabolic dysfunction-associated steatotic liver disease: evidence from NHANES 2005-2018
Authors: Li Xiang , Yu HuiYuan , Zhang Yi , Gong Junyi , Ni Xiang , Yin Junli , Lv Zheng 
Published: November 2024

Abstract

The American Heart Association updated the cardiovascular health (CVH) assessment tool, the Life's Essential 8 (LE8). Metabolic dysfunction-associated steatotic liver disease (MASLD) is now the most common chronic liver disease worldwide and is associated with excessive mortality risk. 10050 participants with MASLD were included from NHANES 2005–2018. LE8 was assessed by combining 4 health behaviors and 4 health factors, with 0–49 being low CVH, 50–79 being moderate CVH, and 80–100 being high CVH. In the fully adjusted model, each point increase in the LE8 score was associated with a 2.7%, 2.7%, and 1.6% decrease in all-cause, CVD, and cancer mortality risk, respectively, in people with MASLD. Compared to low CVH, being in moderate/high CVH was negatively associated with most mortality outcomes, while health factors lost significant association with cancer mortality. Most of the associations showed dose-response associations, except for health factors and all-cause mortality and LE8 and CVD mortality. Race/ethnicity and income-poverty ratio significantly influenced the association between LE8 and all-cause mortality.LE8 was associated with significantly lower all-cause, CVD, and cancer mortality in people with MASLD. Assessment of CVH by LE8 may contribute to targeted healthy lifestyle and factor modification to prevent excess mortality in MASLD.
Clinical Characteristics and Risk Factors of Bacillary Layer Detachment in Central Serous Chorioretinopathy: A Comparative Multicenter Study
Authors: Casella Antonio M , Fuganti Raphaella M , Mansour Ahmad M , Fernández-Vigo José Ignácio , Sinawat Suthasinee , Saatci Ali , Chhablani Jay , Zarnegar Arman , Prazeres Juliana , Kozak Igor , Guajardo Lorenzo López , Farah Michel E , Roisman Luiz , Zett Claudio , Rodriguez Francisco , Smiddy Willian E , Davis Janet L , Rosenfeld Philip J , Schwartz Stephen G , Lima Luiz H , Maia Maurício 
Published: November 2024

Abstract

Purpose
Compare the clinical characteristics, risk factors, and optical coherence tomography (OCT) findings in patients with Central Serous Chorioretinopathy (CSC) with and without Bacillary Layer Detachment (BALAD), and to identify the distinguishing features and associated conditions of CSC with BALAD.
Methods
This observational, retrospective, multicenter case-control study collected data from 12 retina centers worldwide on patients with central serous chorioretinopathy (CSC) from December 1, 2022, to April 1, 2023. CSC was defined by serous retinal detachment and fluid leakage through the retinal pigment epithelium. Patients underwent detailed evaluations, including OCT, and were classified as having acute or chronic CSC. Inclusion criteria included a CSC diagnosis with RPE leakage, BALAD confirmed by three authors, age over 18, and a detailed medical history from the 30 days before symptom onset. The study assessed visual acuity, choroidal thickness, psychiatric disorders, corticosteroid use, prior CSC treatments, and hyperreflective material on OCT.
Results
Thirty-seven patients (40 eyes; mean age, 48.0 ± 11.9 years) had CSC and BALAD and were followed for a mean of 4.92 ± 6.65 months. The control group was comprised of 40 patients with CSC without BALAD (40 eyes; mean age, 48.2 ± 11.9 years). On clinical examination, BALAD was as a circular, yellowish macular lesion. On OCT, BALAD was a detachment of the ellipsoid zone with splitting of the photoreceptor inner segment. BALAD was associated with psychiatric disorders (p = 0.014), use of corticosteroids (p = 0.004), previous treatment for CSC (p = 0.041) and thickened choroid (p = 0.036).
Conclusions
BALAD in CSC differs from a typical CSC due to the presence of a circular, yellowish macular lesion, detachment of the ellipsoid zone, segmentation of the inner segment of the photoreceptor, a thicker choroid, the use of corticosteroids, and generally more aggressive previous treatments. These results suggest that BALAD may serve as a valuable biomarker for the severity of CSC and highlight the influence of inflammation and previous treatments.
Clinical characteristics and treatment response of a possible self-contamination subtype of obsessive-compulsive disorder: a prospective investigation
Authors: Mukai Keiichiro , Yamanishi Kyosuke , Hosoi Yukihiko , Sakurai Masahiko , Ogino Shun , Maebayashi Kensei , Hayashida Kazuhisa , Matsunaga Hisato 
Published: November 2024

Abstract

Background
Obsessive-compulsive disorder (OCD) present invasive thoughts and repetitive behaviors affecting 1–3% of the population, divided into 3–5 symptom dimensions. Self-contamination, a subtype within the contamination/washing dimension, remains poorly understood. This study aim is to investigate pathological features and treatment response in self-contamination subtype compared to other contamination subtype and checking symptoms.
Method
Seventy-one OCD patients were categorized into self-contamination (n = 15), contaminated (n = 25), and checking symptom (control, n = 31) groups. OCD symptom severity was assessed using the Japanese version of the Yale-Brown Obsessive-Compulsive Scale (Y-BOCS) Symptom Checklist. Comorbidities were evaluated using the Structured Clinical Interview for DSM-IV. Global functioning, anxiety, and depressive symptoms were measured using DSM-IV's Global Assessment of Functioning Scale (GAFS), State-Trait Anxiety Inventory, and Zung’s Self-rating Depression Scale, respectively. Treatment involved a standardized combination of selective serotonin reuptake inhibitors and cognitive-behavioral therapy, with treatment response assessed after 1 year.
Results
Subjects in the self-contamination group showed significantly lower quality of life, GAFS scores, and higher comorbidities including major depressive disorder, social anxiety disorder, body dysmorphic disorder, and olfactory reference disorder. Treatment response was notably poorer in the self-contamination group. Multiple regression analysis identified four poor treatment outcome predictors: score on the Y-BOCS and the SDS, duration of illness, and prevalence of ORD.
Conclusion
The identification of the self-contamination subtype in OCD patients is crucial for understanding the pathophysiological and treatment response. Further research is needed to clarify the socio-cultural effects on the development of this putative subtype of OCD.
Advancing Depression Risk Assessment in Connective Tissue Diseases: A Multi- Classification Machine Learning Approach
Authors: Yang Leilei , Jin Yuzhan , Lu Wei , Wang Xiaoqin , Yan Yuqing , Tong Yulan , Su Dinglei , Huang Kaizong , Zou Jianjun 
Published: November 2024

Abstract

This study retrospectively collected clinical data from 480 patients with connective tissue diseases (CTDs) at Nanjing First Hospital between August 2019 and December 2023 to develop and validate a multi-classification machine learning (ML) model for assessing depression risk. Addressing the limitations of traditional assessment tools, six ML models were constructed using univariate analysis and the LASSO algorithm, with the artificial neural network (ANN) model emerging as the best performer, demonstrating strong predictive ability across different depression severity levels (none_F1=0.849, mild_F1=0.621, moderate and severe_F1=0.571). Additionally, the study provided an interpretation of the best-performing model using SHAP and developed a user-friendly R Shiny application (https://macnomogram.shinyapps.io/ANN-CTD/) to facilitate clinical use. The findings suggest that the ANN model represents a significant advancement in assessing depression risk among CTD patients, highlighting the potential of ML in enhancing mental health management for this patient population.
Genetic Predisposition of Metabolic Dysfunction-Associated Steatotic Liver Disease: A Population-based Genome-wide Association Study
Authors: Wang Shao-Wen , Wang Ching , Cheng Yu-Ming , Chen Chun-Yi , Hsieh Tsung-Han , Wang Chia-Chi , Kao Jia-Horng 
Published: November 2024

Abstract

Background/Purpose:
Although metabolic dysfunction-associated steatotic liver disease (MASLD) has been proposed to replace the diagnosis of non-alcoholic fatty liver disease (NAFLD) with new diagnostic criteria since 2023, the genetic predisposition of MASLD remains to be explored.
Methods
Participants with data of genome-wide association studies (GWAS) in the Taiwan Biobank database were collected. Patients with missing data, positive for HBsAg, anti-HCV, and alcohol drinking history were excluded. MASLD was defined if having hepatic steatosis on ultrasound, plus at least one of cardiometabolic criteria. The Taiwan biobank used two genetic chips during the period of data collection: Taiwan biobank version 1 (TWBv1) as the initial chip and TWBv2 specifically designed for the Taiwanese population. TWBv2 was used as test group and TWBv1 as validation group. NAFLD fibrosis score (NFS) was used to assess the degree of liver fibrosis, and carotid plaques on duplex ultrasound were employed for the diagnosis of atherosclerosis.
Results
In a total of 16,407 (mean age 55.35 ± 10.41; 29.6% males) participants, 6,722 (41.0%) had MASLD. Eleven single-nucleotide polymorphisms (SNP) were identified to be associated with MASLD. Their functions were exonic in two and intronic in nine. They were related to the PNALA3, and SAMM50 genes located on chromosome 22. The linkage disequilibrium showed a high correlation with each other. Four SNPs of PNALA3 and SAMM50 genes had increased risk of MASLD and higher levels of AST/ALT. In addition, there was no association of these two genes with glucose metabolism, but better lipid profiles in SAMM50.
Conclusions
This large GWAS study indicates that eleven SNPs of PNPLA3 and SAMM50 genes predispose the development of MASLD in Taiwanese population.
Microbial Stimulation in Apple Orchards of Different Ages on the Loess Plateau: Poor Predictability of Increased Soil N2O Emissions
Authors: Zhang Man , Li Cui , Wang Weixin , Tong Xin , Wang Kaixuan , Qiang Minmin , Zhang Qiong 
Published: November 2024

Abstract

Aims
The continuously expanding apple plantation and excessive nitrogen input have made it a major source of nitrous oxide (N2O) emissions over the past 40 years in the Loess Plateau, China. However, the difference in N2O emissions from different stand ages of orchards and its key driving factors remain unclear.
Methods
A three-year field study was set up to evaluate the soil N2O emissions and the soil properties in apple orchards of two different stand ages (young orchard: 5 years and old orchard: 25 years), and soil bacteria, fungi, ammonia oxidizing bacteria (AOB) and denitrification bacteria (nirS) were determined via amplicon sequencing.
Results
The higher N2O emissions and emission factors (EFs) were recorded in the old apple orchard under the conventional nitrogen (N) strategy. The microbial community composition in topsoil was obviously shifted by stand age (22.2% interpretation, P = 0.022) and stand age and fertilization also had a combined effect (36.6% interpretation, P = 0.003). The relative abundances of Firmicutes and Basidiomycota involved in the decomposition of plant residues increased with stand age. Nonetheless, N2O fluxes were not significantly correlated with soil nitrifiers and denitrifiers, but were strongly correlated with NO3−-N, NH4+-N, soil moisture and enzyme activity. In general, abiotic factors, especially mineral N availability, resulted in differences in N2O emissions between orchards of different stand ages.
Conclusions
The selection of future N2O emissions mitigation strategies for apple orchards should take into account both nonbiological processes and biological processes, and the assessment of N2O emissions in apple orchards should consider stand age.