bluuebunny/crossref_metadata_2025_split huggingface dataset:
Genetic Alleles Associated with SLE Susceptibility and Clinical Manifestations in Hispanic Patients from the Dominican Republic
Authors: Liu Zheng , Yu Yangsheng , Yue Yinshi , Hearth-Holmes Michelene , Lopez Persio David , Tineo Carmen , Paulino Glenny , Fu Wei-Neng , Loyo Esthela , Su Kaihong 
Published: April 2019

Purpose:
Systemic lupus erythematosus (SLE) is a complex autoimmune
disease with marked disparities in prevalence and disease severity among different
ethnic groups. The purpose of this study is to characterize a Latin American cohort and
identify genetic risk factors for developing SLE and its end-organ manifestations in this
Latin Hispanic cohort.

Methods:
In this cohort, SNP rs9271366 (tag SNP for HLA-DRB1*15:01) confers the
highest risk for SLE among the 13 MHC gene alleles that display association with SLE
(p = 8.748E-10; OR = 3.5). Among the 26 non-MHC gene alleles analyzed, SNP
rs2476601 in PTPN22 gene confers the highest risk for SLE (p = 0.0001; OR = 5.6).
ITGAM, TNFSF4, TNIP1, STAT4, CARD11, BLK, and TNXB gene alleles were
confirmed as SLE-susceptible alleles in the DR cohort. However, IRF5 and TNFAIP3
gene alleles, established risk factors for SLE in populations of European and Asian
ancestry, are not significantly associated with SLE in this cohort. We also defined a
novel HLA-DRA haplotype that confers an increased risk for lupus nephritis (LN) and
alleles in HLA-DRA2 and TNFSF4 genes as genetic risk factors for developing
neuropsychiatric (NP) SLE.

Results:
In this cohort, SNP rs9271366 (tag SNP for HLA-DRB1*15:01) confers the
highest risk for SLE among the 13 MHC gene alleles that display association with SLE
(p = 8.748E-10; OR = 3.5). Among the 26 non-MHC gene alleles analyzed, SNP
rs2476601 in PTPN22 gene confers the highest risk for SLE (p = 0.0001; OR = 5.6).
ITGAM, TNFSF4, TNIP1, STAT4, CARD11, BLK, and TNXB gene alleles were
confirmed as SLE-susceptible alleles in the DR cohort. However, IRF5 and TNFAIP3
gene alleles, established risk factors for SLE in populations of European and Asian
ancestry, are not significantly associated with SLE in this cohort. We also defined a
novel HLA-DRA haplotype that confers an increased risk for lupus nephritis (LN) and
alleles in HLA-DRA2 and TNFSF4 genes as genetic risk factors for developing
neuropsychiatric (NP) SLE.

Conclusion:
Our data suggest that the Latin American population shares some
common genetic risk factors for SLE as other populations, but also has distinct risk gene
alleles that contribute to SLE susceptibility and development of LN and NPSLE. This is
the first study focusing on genetic risk factors for SLE in the DR, a Latin American
population that has never been characterized before.
Notch Signaling in Mammalian Intestinal Stem Cells: Determining Cell Fate and Maintaining Homeostasis
Authors: Liang Shao-jie , Li Xiang-guang , Wang Xiu-qi 
Published: April 2019

:
The intestine serves mainly as a place for digestion and absorption and functions as an immune
and endocrine organ. Intestinal stem cells (ISCs) play critical roles in the maintenance of intestinal homeostasis
and regeneration, and a complex of signaling pathways is involved in these processes. The
Notch signaling pathway is induced via distinct cell-to-cell connections, which are activated through the
binding of the Notch ligand on the surface of niche cells to the Notch receptor on ISCs. Numerous studies
have shown the central importance of Notch signaling in the proliferation and differentiation of ISCs.
Here, we summarize the latest research progress on the crucial functions of Notch signaling in maintaining
homeostasis and determining the cell fate of ISCs. Furthermore, the challenges of Notch signaling in
colon cancer therapy strategies are also discussed. Several important questions regarding Notch regulation
of ISCs are proposed.
Peak Average Power Reduction in NOMA by using PTSCT Technique
Authors: Kumar Arun , Gupta Manisha 
Published: April 2019

Background:
High peak power is one of the several disadvantages which need to be addressed
for its effective regularization. It hampers the performance of the system due to the utilization
of the orthogonal frequency division multiplexing transmission scheme at the sender of the
Non-orthogonal multiple access system.

Objective:
In this work, a new Partial transmission sequence circular transformation reduction technique
is designed for Non-orthogonal multiple access schemes.

Methods:
Partial transmission sequence is considered to be one of the most efficient techniques to
reduce the Peak to average power ratio but it leads to high computational complexity. Additionally, a
circular transformation is implemented. In the proposed technique, circular transformation and alternate
optimization are used.

Results:
Simulation results reveal that the Peak to average power ratio performance of the proposed
technique is better as compared to the conventional partial transmission sequence.

Conclusion:
It is observed that the proposed technique achieved 80% Peak to average power ratio reduction
and 90 % bit error rate performance as compared to the conventional Partial transmission sequence.
Characterizing Participation and Perceived Engagement Benefits in an Integrated Digital Behavioral Health Recovery Community for Women: A Cross-Sectional Survey
Authors: Curtis Brenda , Bergman Brandon , Brown Austin , McDaniel Jessica , Harper Kristen , Eisenhart Emily , Hufnagel Mariel , Heller Anne Thompson , Ashford Robert 
Published: April 2019

Background
Research suggests that digital recovery support services (D-RSSs) may help support individual recovery and augment the availability of in-person supports. Previous studies highlight the use of D-RSSs in supporting individuals in recovery from substance use but have yet to examine the use of D-RSSs in supporting a combination of behavioral health disorders, including substance use, mental health, and trauma. Similarly, few studies on D-RSSs have evaluated gender-specific supports or integrated communities, which may be helpful to women and individuals recovering from behavioral health disorders.

Objective
The goal of this study was to evaluate the SHE RECOVERS (SR) recovery community, with the following 3 aims: (1) to characterize the women who engage in SR (including demographics and recovery-related characteristics), (2) describe the ways and frequency in which participants engage with SR, and (3) examine the perception of benefit derived from engagement with SR.

Methods
This study used a cross-sectional survey to examine the characteristics of SR participants. Analysis of variance and chi-square tests, as well as univariate logistic regressions, were used to explore each aim.

Results
Participants (N=729, mean age 46.83 years; 685/729, 94% Caucasian) reported being in recovery from a variety of conditions, although the most frequent nonexclusive disorder was substance use (86.40%, n=630). Participants had an average length in recovery (LIR) of 6.14 years (SD 7.87), with most having between 1 and 5 years (n=300). The most frequently reported recovery pathway was abstinence-based 12-step mutual aid (38.40%). Participants reported positive perceptions of benefit from SR participation, which did not vary by LIR or recovery pathway. Participants also had high rates of agreement, with SR having a positive impact on their lives, although this too did vary by recovery length and recovery pathway. Participants with 1 to 5 years of recovery used SR to connect with other women in recovery at higher rates, whereas those with less than 1 year used SR to ask for resources at higher rates, and those with 5 or more years used SR to provide support at higher rates. Lifetime engagement with specific supports of SR was also associated with LIR and recovery pathway.

Conclusions
Gender-specific and integrated D-RSSs are feasible and beneficial from the perspective of participants. D-RSSs also appear to provide support to a range of recovery typologies and pathways in an effective manner and may be a vital tool for expanding recovery supports for those lacking in access and availability because of geography, social determinants, or other barriers.
KAMU HASTANELERİ BİRLİĞİ YAPILANMASININ SAĞLIK HİZMETİ SUNUM SÜREÇLERİNE ETKİSİNİN YÖNETİCİ VE ÇALIŞAN AÇISINDAN DEĞERLENDİRİLMESİ
Authors: BOSTAN Sedat , AĞAÇ Gökhan 
Published: April 2019

Amaç: Bu çalışma, sağlıkta dönüşüm programının çatı uygulaması olan kamu hastane birlik yapılanmasının hastane hizmetleri üzerindeki değişim etkisini yönetici ve çalışan görüşleri üzerinden mukayeseli araştırmak olup 2017 yılında sistemde yapılan değişikliği bu veriler üzerinden tartışmaktır. Yöntem: Araştırmada verilerin toplanmasında dörtlü Likert yapıda bir anket formu kullanılmıştır. Bostan ve arkadaşları (2012) tarafından sağlıkta dönüşüm programının hastane hizmetleri üzerindeki değişim etkisini ölçmek üzere geliştirdikleri ölçek bu çalışmaya uyarlanarak kullanılmıştır. Üç kamu hastaneleri birliği yapılanmasına bağlı yedi hastaneden 325 yönetici ve sağlık çalışanı katılımıyla veriler toplanmıştır. Ölçeğin güvenirlik ve geçerliliği test edildikten sonra veriler tanımlayıcı istatistiksel yöntemler ile bağımsız örneklerde t testi kullanılarak analiz edilmiştir.Bulgular: Uygulama sonuçlarına göre, sağlık yöneticileri ve sağlık çalışanları kamu hastane birlikleri uygulamasıyla kamu hastanelerinde meydana gelen yönetsel alandaki değişimin olumlu yönde (2,75/2,73) gerçekleştiğini, ortaya çıkan sayısal değişimlerin artış yönünde (2,52/2,53) olduğunu, genel olarak hizmet bileşenlerinin öneminin (3,09/2,86) artığını ifade etmişlerdir. Ayrıca, hem sağlık yöneticileri hem de sağlık çalışanlarına göre kamu hastanelerindeki sağlık çalışanı açısından değişimin olmadığını (2,31/2,28) ve kamu hastaneleri hakkında kamuoyundan duyduğu görüşlerin olumlu (2,81/2,72) olduğu görülmüştür.Sonuç: Araştırma bulgularına göre; kamu hastane birlikleri uygulamasının sağlık çalışanı ve hastane yöneticilerinin ifadelerine göre, önemli ölçüde benimsendiği, olumlu yönde değişimin sağlandığı, hasta memnuniyetinde artış olduğu, etkin ve yerinden yönetimin öne çıktığı anlaşılmıştır. Bununla birlikte, sağlık çalışanlarının dönüşümden yeterli pay alamadıkları söylenebilir.
AKILLI KENT LOJİSTİĞİNİN MEKANSAL İLİŞKİLENDİRİLMESİ
Authors: AYDIN Gülşen T. , ÖZTÜRK Zübeyde 
Published: April 2019

Amaç: Bu çalışma, sürdürülebilir kentsel gelişmeyi teşvik etmek için kentsel alanlardaki yük, filo ve bilgi hareketinin akıllandırılmasının yararlarını, arazi yer seçimine ve kullanımına etkilerini, mekansal ilişkilenmesini, kente ve kentsel yük mobilitesine getirdiği kolaylıkları açıklamayı amaçlamaktadır.Yöntem: Çalışma, nitel araştırmanın avantajlarından yararlanmayı hedeflemiştir. Çalışmada akıllı kent, akıllı kent lojistiği, kentsel lojistik, kent planlama, kent lojistik planlaması, akıllı ulaşım sistemleri, kentsel lojistik bilgi teknolojileri, ulaşım ve lojistik karar verme süreci, karar destek sistemleri, lojistik ağ tasarımı, modelleme, coğrafi bilgi sistemleri, çoklu taşıma, yeni araç teknolojileri vb. gibi anahtar kavramların yabancı ve yerli bilimsel literatür taraması yapılmıştır. Çalışmada Avrupa'da yapılan bir anket çalışmasının sonuçlarına da yer verilerek, akıllı kent lojistiği bilinci Avrupa düzeyinde irdelenmeye çalışılmış ve gerçekleşmiş güncel uygulamalarla yeryüzünde kullanım ilişkilerine örnekler verilmiştir. Bulgular ve Sonuç: Kentsel lojistik ve ulaşım altyapı verileri elde etmek, kentsel dağıtım ağ tasarımı ve planlaması yapmak, gerçek zamanlı sorgu imkânları olan akıllı bilgi platformları ve kentsel mal dağıtımında akıllı zamanlama gibi araştırma konularında akıllı kent lojistiğinin mekanla olan ilişkisi, mekana olan etkileri ile kente ve kentsel yük mobilitesine getirdiği kolaylıklar açıklanmıştır. Yine akıllı kent lojistiğinin, kent planlama, karar destek sistemleri, lojistik ağ, tesis planlama ve tasarımı ile yer seçimi, modelleme, trafik, gerçek zamanlı veriye erişim ve bulut teknolojisi, veri analizi, akıllı çevre dostu araçlar, çoklu yük taşıma (intermodal-multimodal taşıma) otomasyon sistemleri, operasyon yönetim yazılım ve donanımları gibi kent lojistiğinin akıllandırılarak kent mekana indirgenmesi için gereken analitik ve entegrasyonal birçok farklı kullanım alanları ortaya konmaya çalışılmıştır. Çalışma, akıllı kent lojistiğinin mekansal boyutu ve ilişkisi ile kent günlük yaşamını etkileyen avantajlarını ortaya koymaktadır.
"Heloisa Schneiders da Silva: obra e escritos", organized by Mônica Zielinsky
Authors: Fabris Annateresa 
Published: April 2019

The book "Heloisa Schneiders da Silva: obra e escritos" (or "Heloisa Schneiders
da Silva: work and writings"), 2010, includes two essays – one from the volume’s organizer Mônica Zielinsky and the other by Gaudêncio Fidelis – a documental section, a chronology, and also reproductions of the artist’s works and pictures from the late 1970s to 2005, year she passed away.
THE STUDY CORRELATION BETWEEN READING HABIT AND PRONUNCIATION ABILITY AT THE SECOND GRADE STUDENTS OF IKIP SILIWANGI
Authors: Parmawati Aseptiana 
Published: April 2019

Language has central role on intellectual development, social, and emotional students to supported success student and learn all of lessons. Literacy level are performation, functional, informational, and epistemic. Performative level means students able to read, to write, to listen, and to speak using symbols. Reading habit refers to the automatic process as the readers read the textual material and deriving meaning unconsciously. A good reading habit is important for the development of personalities and mental capacities. Students reading habit plays an important role in pronunciation mastery. This research used the correlation research. The objectives of the study is to reveal correlation between students’ reading habit and their pronunciation ability at second grade students of IKIP Siliwangi. The finding was supported by the result of students’ scores. The minimum score of habit is 71 and 65 for pronunciation ability. The maximum score of reading habit is 109 and 92 for pronunciation ability. The mean of reading habit is 92.60 and 78.73 for pronunciation ability. Standard deviation of reading habit is 8.85 and 6.31 for pronunciation ability. The researcher finds that the Pearson Product Moment of both variable is 0.373. It means that the correlation between students’ reading habit in English and their pronunciation ability was in low correlation because in the range of 0.20-0.40. From the result of the statistical calculation, it can be synthesized that Null Hypothesis (Ho) is rejected. The researcher concluded that there is the correlation between students’ reading habit and their pronunciation ability. Keywords: Reading habit, Pronunciation, Correlation
TEACHER’S DIFFICULTIES IN TEACHING SPEAKING USING AUDIO VISUAL AID FOR AUTISTIC STUDENTS
Authors: Haryudin Acep , Jamilah Siti Ariani 
Published: April 2019

This article was to identify and to find out the teacher’s difficulties in teaching speaking to autistic student using audio visual. This research used descriptive design and qualitative research method. The instrument of the research are observation, interview and questionnaire about expressions of greetings. The data are collected by giving the teacher and autistic student interview, questionnaire and does observation and video recording. Additionally, the writer found that respondent’s difficulties in teaching speaking using audio visual aid for autistic student, divided into two sections: Internal; insecure and external that are 1) student; perform unique and unfamiliar character, deficit attention and concentrations, different of learning style, habit, and socialite with others, hard to produce and distinguish words with proper pronunciation, hard to perfect in pronunciation, easily affected by their surroundings, using verbal and imagination in the way of learning. 2) Media; looking for a precise and compelling media, requiring a long time preparation. 3) Teaching process; should be interesting, should provide examples that are easy to understand, always tuck the material outside of school hours, need a lot of repetition, takes a long time. Additionally, it is recommended for further researchers to conduct similar studies in different contexts deeper.
GENDER REPRESENTATION IN TEXTBOOK BAHASA INGGRIS GRADE X
Authors: Rachmijati Cynantia , Cahyati Sri Supiah 
Published: April 2019

According to ACDP Indonesia, many gender bias contents found in textbooks Bahasa Inggris in Indonesia settings. This study aims at examining the representation of gender on “BahasaInggriskelas X” by Kemendiknas. The criteria of a good textbook should show the relationship of women and men in society based on their role, status, environment, culture and community structures which are displayed in the form of illustrations and descriptions of the sentence. Findings from the book regarding Text: 4,11% visual characters, 28,77% characters mentioned, 57,54% social activities, and 9,58% domestic activity. While findings regarding Visual: 88,89% social activities and 11,11% regarding domestic. Furthermore, the Frequency of occurrence: for male 51,89%. and female 48,11% .Not too many domestic roles and settings found in the book probably because the book is created to inline with Curriculum 2013 where the main purpose of Curriculum 2013 is to develop social skills. It can be concluded that gender representation in this book is dominated by male.
A aprendizagem de Geometria com foco na desconstrução dimensional das formas<br>The learning of Geometry focusing on dimensional deconstruction of forms
Authors: Sodré de Souza Roberta Nara , Moretti Mericles Thadeu , Almouloud Saddo Ag 
Published: April 2019

O presente artigo traz para discussão a desconstrução dimensional das formas como elemento relevante a se considerar na aprendizagem da geometria. A investigação baseou-se em aportes teóricos de Duval que traz a desconstrução dimensional das formas como intrínseca à aprendizagem em geometria. A pesquisa teórica/prática baseada em princípios da Engenharia Didática faz uma análise semiótica e cognitiva das produções de alunos do Ensino Médio em problemas que contenham figuras geométricas. A desconstrução dimensional das formas mostrou-se ser uma operação cognitiva requerida e fundamental à resolução de problemas com figuras se configurando no momento seguinte às apreensões perceptiva e discursiva e agindo no planejamento heurístico da ação do sujeito que o encaminhando para um olhar não icônico que decompõe os elementos constitutivos da figura, permitindo a solução do problema. O presente estudo nos direciona à necessidade do olhar docente à proposição de problemas com intencionalmente para o desenvolvimento da desconstrução geométrica favorecendo as operações na figura em suas dimensoes inferiores
Estado da arte das pesquisas acadêmicas brasileiras sobre concepções de Professores que ensinam Matemática (2001 - 2012)<br>State of the art of Brazilian academic researches on conceptions of teachers who teach Mathematics (2001 - 2012)
Authors: Rocha Vanessa Amélia da Silva , Barros Roseli Araujo 
Published: April 2019

O texto apresenta um estado da arte das pesquisas acadêmicas brasileiras, acerca das concepções de Professores de Matemática, produzidas no período de 2001 a 2012. Os trabalhos selecionados fazem parte do projeto Mapeamento da pesquisa acadêmica brasileira sobre o professor que ensina Matemática, coordenado pelo GEPFPM. Para delimitar nosso corpus de análise, estabelecemos os seguintes critérios: (i) no caso da dissertação que fosse advinda do Mestrado Acadêmico; (ii) que assumissem um conceito para concepção e, (iii) realizado na formação inicial, no caso, na licenciatura em Matemática. Dentre os trabalhos selecionados, oito satisfizeram aos critérios estabelecidos, sendo três teses e cinco dissertações. A partir da análise realizada, pode-se perceber que muitos autores utilizam o termo concepção sem discrepância.
ASSESORIS KREATIF DARI SAMPAH BAGI ANAK ASUH DI PANTI ASUHAN AISYIYAH KOTO TANGAH MUARO PENJALINAN KOTA PADANG
Authors: Susilawati Nora , Naldi Hendra 
Published: April 2019

Sampah adalah sesuatu yang biasanya dipandang oleh orang sebagai barang yang kotor, tidak berguna, dan harus dibuang. Ini adalah suatu persepsi yang tidak tepat, karena sampah jika diolah dengan baik dan kreatif dapat menjadi barang yang berguna dan bernilai ekonomi. Jadi, sampah tidak selamanya harus dibuang, karena dapat diubah menjadi beraneka produk yang berharga. Sampah-sampah seperti sampah plastik, botol-botol bekas dan kain perca dapat diubah menjadi tas, bros, kotak pensil, payung, bunga dan lain sebagainya. Tulisan ini akan menguraikan bagaimana pembuatan assesoris kreatif yang dibuat oleh para anak asuh di Panti Asuhan Aisyiyah Koto Tangah Muaro Penjalinan Kota Padang. Assesoris yang dibuat adalah bros, tas kecil, dan kotak pensil yang terbuat dari kain-kain perca yang tidak terpakai. Sebelum pembuatan assesoris terlebih dulu diberikan pengetahuan tentang dampak sampah terhadap manusia dan lingkungan dan bagaimana mengolah sampah tersebut menjadi sesuatu yang bermanfaat dan bernilai ekonomi.
PROSES ICONIX DALAM ANALISA RANCANGAN APLIKASI INFORMASI JADWAL DAN TUGAS BERBASIS ANDROID
Authors: Ristyawan Aidina , Harini Dwi 
Published: April 2019

Dalam pembuatan suatu perangkat lunak yang efisien dan sesuai dengan kebutuhan fungsional pengguna, dibutuh suatu analisa perancangan yang mampu menjembatani antara kebutuhan pengguna dengan proses pembuatan kode perangkat lunak, dari analisa perancangan yang tepat maka akan memudahkan pengembang membuat kode perangkat lunak. Terdapat beberapa model yang dapat menggambarkan analisa perancangan untuk pembuatan suatu perangkat lunak. Model tersebut diantaranya yang sering digunakan adalah UML. Namun dengan banyaknya diagram notasi UML sering membuat kita beranggapan bahwa UML merupakan langkah – langkah apa saja yang harus dilakukan dalam merancang sistem atau perangkat lunak. Padahal UML sebenarnya hanya kumpulan diagram / notasi dan teknik visualisasi, tidak menentukan urutan – urutan langkah dalam membuat perangkat lunak. Dengan menggunakan ICONIX Process kita dapat menggunakan UML untuk menggambarkan model perancangan dan sekaligus menganalisa dari rancangan yang kita buat. Pada penelitian ini peneliti membuat diagram analisa dan perancangan yang nantinya dapat digunakan sebagai panduan atau gambaran umum dalam pembuatan perangkat lunak informasi jadwal dan tugas kuliah berbasi android. Pada penelitian ini hanya membahas tentang model analisa dan perancangannya saja.
PEACH ANTIOXIDANT AND PHENOLIC ACTIVITIES INFLUENCED BY THE APPLICATION OF 1-METHYLCYCLOPROPENE (1-MCP) AT POST-HARVEST
Authors: Shah Syed Tanveer , Sajid Muhammad , Khan Naqib Ullah , Rab Abdur , Amin Noor Ul , Arif Muhammad , Haleema Bibi , Saeed Sana 
Published: April 2019

Early maturing peach (Prunus persica) cultivars can fetch good market value but face a lot of post-harvest problems that lead to the post-harvest losses. The 1-methylcyclopropene (1-MCP) can provide new insights into plant ethylene responses and extend the shelf life and quality of fruits. Therefore, fruits of peach cultivar ‘Early Grand’ were dipped in various concentrations of 1-MCP (0, 0.3, 0.6 and 0.9 µg l–1), stored for 40 days at 8 ±2°C with 50% relative humidity and analyzed the fruits for physicochemical attributes at 10 days interval. The highest concentration of 1-MCP at 0.9 µg l–1 significantly improved the activity of antioxidants, catalase, free radical scavenging assay and total phenols. However, the peach fruits treated with 1-MCP at 0.6 µgL–1 was effective in retaining the ascorbic acid, lowering the weight loss and fruit decay. Therefore, peach fruits can be treated with 1-MCP (0.6 µg l–1) solution for prolonging its shelf life up to 40 days under low temperature.