bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Fluorinated Ether Co-solvent Enables High Operating Temperature Li-ion Batteries
Authors: Wang Jonah , Keating Michael J. , Asare Harrison , Biddinger Elizabeth J. , Messinger Robert J. , West William C. , Jones John-Paul 
Published: December 2024

Li-ion batteries are commonly used as electrochemical energy storage systems due to their high energy density. However, few Li-ion batteries can reliably function at elevated temperatures, which is necessary for space and defense applications. In this study, Li-ion electrolytes were prepared and investigated for use at 100 °C. The previously developed baseline electrolyte, 1.0 M lithium hexafluorophosphate (LiPF6) in 1:1 ethylene carbonate (EC):ethyl-methyl carbonate (v/v) with 2 wt% vinylene carbonate (VC), was altered to observe the effects of the lithium salts lithium difluoro(oxalato)borate (LiDFOB) and lithium difluorophosphate (LiDFP), and the fluorinated co-solvent 1,1,2,2-tetrafluoroethyl-2,2,3,3-tetrafluoropropyl ether (TTE). The resulting formulations showed significantly improved capacity retention at 100 °C in multiple cell configurations. X-ray photoelectron spectroscopy characterization of the electrodes following cycling at high temperatures with the improved electrolyte revealed the cathode-electrolyte-interface to be boron-rich, while the graphite anodes were found to have little boron but were more fluorine rich compared to the baseline anodes. Raman spectroscopy determined notable changes in solvation structure upon addition of the TTE diluent. Overall, the use of various Li salts as well as the TTE co-solvent improved specific capacity retention at 100 °C in Li-ion cells.
Exploring the Pharmacists’ Knowledge, Attitude, and Practice During COVID‐19: A KAP Model Approach
Authors: Ghaith Abrar , Alghreiz Islam , Afifi Tayseer 
Published: December 2024

Background: The coronavirus disease 2019 (COVID‐19) pandemic had a major effect on economics, cultures, and world health. Effective prevention, management, and control of the virus depend on an understanding of its origins and early conditions. This study examines pharmacists’ knowledge, attitudes, and practices (KAPs) on COVID‐19 prevention and control in Kuwait using the KAPs approach.Methods: From August 15 to August 30, 2022, a cross‐sectional survey design was used in the study. A convenience sample of 400 participants was obtained. Data were collected via an online survey that consisted of demographic questions and a KAPs survey about COVID‐19. The survey had been piloted before and was deemed to have a respectable level of dependability. Based on predetermined scoring levels, participants’ anonymous replies were divided into categories such as adequate/inadequate knowledge, positive/negative attitudes, and appropriate/inappropriate practices.Results: Half of the participants were married, and most of the participants were female. They were mostly in the age range of 31–40 years. The most common highest level of education attained was a master’s degree. There were noticeable differences in the demographics. Overall, 83.5% of participants showed adequate knowledge, 94% had a good attitude, and 52.5% had appropriate practice. Males had a greater understanding of transmission but lesser knowledge of clinical presentation. The group with the highest rates of proper behavior and adequate Knowledge was those aged 31–40 years. Being married was associated with higher knowledge. The educational level had a substantial impact on results, with master’s degree holders having greater rates of adequate knowledge. Although knowledge and attitude ratings showed a good correlation, attitude by itself could not significantly predict actual preventative measures, highlighting the necessity for behavior‐change‐focused treatments.Conclusion: This study highlights the significance of educating pharmacists about evidence‐based practices to improve their involvement in COVID‐19 prevention and control. The importance of disseminating clear information via a variety of communication methods is underscored by the positive association found between knowledge and practice. The study focuses on pharmacists in Kuwait in particular since it acknowledges the need to bolster their optimistic outlooks and aggressive involvement in tackling health issues. In conclusion, these results highlight how important focused interventions and education are to successful pandemic management.
Stress and Obesity Signaling Converge on CREB Phosphorylation to Promote Pancreatic Cancer
Authors: Sun Xiaoying , Teper Yaroslav , Sinnett-Smith James , Markarian Mineh , Hines O. Joe , Li Gang , Eibl Guido , Rozengurt Enrique 
Published: December 2024

Abstract
One of the deadliest types of cancer is pancreatic ductal adenocarcinoma (PDAC). Chronic stress and obesity are recognized as risk factors for PDAC. We hypothesized that the combination of stress and obesity strongly promotes pancreatic cancer development and growth. Here, we show that the stress mediator norepinephrine and the β-adrenergic receptor agonist isoproterenol rapidly stimulate cyclic adenosine monophosphate response element-binding protein (CREB) phosphorylation at Ser133 in human PDAC cells. Exposure to the nonselective β-adrenergic receptor antagonist propranolol or selective antagonists, including nebivolol, atenolol, or ICI118551, blocked CREB phosphorylation elicited by norepinephrine or isoproterenol in PDAC cells. Stimulation of PDAC cells with neurotensin, a neuropeptide implicated in obesity and PDAC, also stimulated CREB phosphorylation at Ser133. Mechanistically, norepinephrine induced CREB phosphorylation at Ser133 via PKA, whereas neurotensin promoted CREB phosphorylation predominantly through protein kinase D. Our results indicate that CREB is a point of signal convergence that mediates proliferation in PDAC cells and raised the possibility that stress and diet cooperate in promoting PDAC in vivo. To test this notion, mice expressing KrasG12D in all pancreatic lineages (KC mice) and fed an obesogenic high fat, calorie diet that promotes early PDAC development were subjected to social isolation stress. We show that social isolation stress induced a significant increase in the proportion of advanced PDAC precursor lesions (pancreatic intraepithelial neoplasia) in KC mice subjected to an obesogenic high fat, calorie diet.
Implications: Our data imply that chronic (social isolation) stress cooperates with diet-induced obesity in accelerating the development of pancreatic cancer.
Peri, enfim, fiou-se: o caso da adaptação de O Guarani (2023), de Ailton Krenak
Authors: Salvaia Priscila 
Published: December 2024

No artigo propomos uma breve reflexão a respeito da narrativa O Guarani em três temporalidades: inicialmente, enquanto romance-folhetim (1857), de José de Alencar, e, posteriormente, através das adaptações operísticas ideadas por Carlos Gomes (1870) e Ailton Krenak (2023), respectivamente. A partir do respaldo teórico dos Estudos Pós-Coloniais, temos por fim, especialmente, a montagem contemporânea, na qual o protagonista Peri "transfigura-se" (KRENAK, 2022) entoando a própria voz e a própria ancestralidade.
Webcams as Windows to the Mind? A Direct Comparison Between In-Lab and Web-Based Eye-Tracking Methods
Authors: Slim Mieke Sarah , Kandel Margaret , Yacovone Anthony , Snedeker Jesse 
Published: December 2024

Abstract
There is a growing interest in the use of webcams to conduct eye-tracking experiments over the internet. We assessed the performance of two webcam-based eye-tracking techniques for behavioral research: manual annotation of webcam videos (manual eye-tracking) and the automated WebGazer eye-tracking algorithm. We compared these methods to a traditional infrared eye-tracker and assessed their performance in both lab and web-based settings. In both lab and web experiments, participants completed the same battery of five tasks, selected to trigger effects of various sizes: two visual fixation tasks and three visual world tasks testing real-time (psycholinguistic) processing effects. In the lab experiment, we simultaneously collected infrared eye-tracking, manual eye-tracking, and WebGazer data; in the web experiment, we simultaneously collected manual eye-tracking and WebGazer data. We found that the two webcam-based methods are suited to capture different types of eye-movement patterns. Manual eye-tracking, similar to infrared eye-tracking, detected both large and small effects. WebGazer, however, showed less accuracy in detecting short, subtle effects. There was no notable effect of setting for either method. We discuss the trade-offs researchers face when choosing eye-tracking methods and offer advice for conducting eye-tracking experiments over the internet.
The Politics of Mystical Poetics: Bahrāmshāh b. Masʿūd’s (r. 1117–1157) Patronage of Sanāʾī’s (d. 1131 or 1135) Mystical Poetry
Authors: Zahiremami Parisa 
Published: December 2024

Abstract
Scholarship on the intersection of Islamic mysticism and politics often focuses on the way Sufi authors preach their mystical teachings to rulers. This article draws attention to the role of court poetry composed by authors who are not considered to have been practicing Sufis in promoting and popularizing mystical teachings at royal courts by examining Sanāʾī’s court-patronized poems as early specimen of mystical works that had a political dimension. This political dimension allowed Sanāʾī to promote and legitimize his royal patron Bahrāmshāh (r. 1117–1157) as a perfect ruler. The study highlights the propaganda value of Sanāʾī’s poetry for Bahrāmshāh. Simultaneously, it investigates the ways in which Sanāʾī asserts his agency in his patron-client relationship with Bahrāmshāh. By engaging with a rhetorical feature common in adab writings – that is, Parrhesia or frank speech – Sanāʾī portrays himself as a candid, Sufi-like advisor, who is detached from the material world and can therefore criticize and counsel Bahrāmshāh without fear of punishment. This show of charisma then provides the poet with an opportunity to preach his model of kingship to the ruler and promote his mystical advice as indispensable for proper royal conduct. According to Sanāʾī, an ideal ruler is a perfect man (or a valī) who is a vessel of God. In his panegyrics, he portrays Bahrāmshāh as a valī and perfect man, thereby legitimizing his royal patron over his rival and lord, the Seljuq Sultan Sanjar (r. 1118–1157). Sanāʾī mystico-political poems therefore functioned as a form of cultural capital through which the poet navigated his complex relationship with the court of Ghazna.
Iceland’s Territorial Sea Baselines, Volcanic Eruptions and Sea Level Rise
Authors: Magnússon Bjarni Már , Árnadóttir Snjólaug 
Published: December 2024

Abstract
Volcanic eruptions can have various consequences, including in the field of the international law of the sea. This article addresses the impact that two volcanic eruptions had on the baselines for measuring the breadth of Iceland’s territorial sea. First, the impact of the eruption in 1918 in Katla was addressed by the Supreme Court of Iceland in 1922 which confirmed a district court decision stating that the territorial sea line was not a fixed or determined line on the sea but changed with avulsions and accretions. Second, the sudden appearance of the volcanic island Surtsey in 1963 affected the drawing of straight baselines along the southwestern coast of Iceland. This article addresses the impact of these eruptions on the territorial sea baseline and explains their relevance for current challenges in international law.
Money-Making in Antarctica and Related Challenges to the Antarctic Treaty System
Authors: Bastmeijer Kees , Jabour Julia , Leary David , Wallace Claire 
Published: December 2024

Abstract
This article discusses commercial activities in Antarctica and the challenges these activities pose for the Antarctic Treaty System (ATS). Attention focuses on developments in fishing, tourism and biological prospecting in Antarctica and on possible future ice harvesting. The discussions show that ‘money-making’ in Antarctica has expanded and diversified over the past decades. While all these activities are subjected to existing ATS regulations, many policy questions are waiting for an answer from the 29 countries that jointly govern the Antarctic. A common characteristic regarding all commercial activities is that decision-making to proactively prevent negative impacts and risks to the principles and values of the ATS has proven to be very limited. This can directly affect the resilience of the ATS: continued lack of decision-making is likely to water down and undermine these principles and values, which may also increase tensions between the Consultative Parties to the Antarctic Treaty. It is incumbent on Consultative Parties to work harder to try advance resolution of the outstanding policy issues, particularly in a time when the Antarctic ecosystem is also under increasing pressure from climate change.
An Examination and Analysis of the Historical Development of the Local Church Movement from an Asian Woman’s Perspective
Authors: Chan Janice 
Published: December 2024

Abstract
An examination of the Local Church movement reveals that the major revivalists in the early twentieth century were predominantly women. Yet, most historical sources identify and honor only men as founders and label women as helpers. This has significantly impacted how the church remembers women’s contributions. Although the Local Church often attracts criticism from mainline Protestants because of its unique contextualized theology, members of the communities vigorously defend and advocate for their standpoints. An analysis of the Local Church’s theological development shows that its ecclesiology has been dramatically influenced by the mystical tradition, the Brethren movement, and allegorized and unconventional biblical interpretations of the Local Church. This study engages in a theological dialogue with Veli-Matti Kärkkäinen to call for Christian leaders to widen, deepen, and rethink their understanding of the Local Church movement as its members continue to shape the development of ecclesiology and their practices in the Chinese diaspora.
The Self, Other and Empire
Authors: Blair Anna Ilona 
Published: December 2024

Abstract
For a long time, Taiwan was an island relatively unknown within the Chinese realm. The defeat of the Ming loyalist forces in 1683 would result in the island becoming an official imperial possession of the Qing empire. It was within this context that Yu Yonghe produced the Small Seas Travel Diaries, a travel account documenting his ten-month journey across Taiwan as part of an official expedition to mine for sulphur.
Moving beyond a geographical and ethnographical mode of analysis, in this article I present an alternative view through examining Yu’s literary and historical constructions of identity. The Small Seas Travel Diaries reveals an intricate narrative pertaining to themes of the self, other and empire. This not only highlights the non-linear nature of Yu Yonghe as an explorer-writer, but also can be seen to situate the Small Seas Travel Diaries within a broader context of identity in relation to the empire.
Novel Method to Evaluate the Quantitative Immune Functionality of CAR T-Cells to Analyze the Localization Change of CAR Molecules
Authors: Yasui Hiroshi , Hirano Keiji , Kobayashi Asako , Li Lihua , Takahashi Takuya , Artemenko Margarita , Noda Naotaka , Sadato Daichi , Haraguchi Kyoko , Arai Ayako , Imai Kohzoh , Doki Noriko , Yanagida Masatoshi , Ishigaki Tomohiro 
Published: December 2024

Background: Chimeric antigen receptor (CAR) T cells, genetically synthesized to reprogram T cells to recognize tumor antigen inducing intracellular signaling to destruct tumor cells, is a ground approach to hematological malignancies. As either loss of immune function or exhaustion in CAR T cells is a recurrence mechanism in patients with hematological malignancies who receive CAR T-cell therapy, evaluating CAR T-cell immune functions is a crucial clinical need. In this study, we used molecular imaging flow cytometry (MI-FCM) to develop a new evaluation method to quantitatively determine the immune functionality of CAR T-cells to analyze the change in CAR molecule localization.
Methods: Eight CAR T-cell clones were constructed via genetically modifying peripheral blood mononuclear cells from eight healthy donors (21-69 years old) using lentivirus to express an anti-CD19 CAR (FMC63-41BBz), as previously described by Kochenderfer et al. (J Immunol, 2009). The cytotoxic activity of these clones was then evaluated in vitro. Each clone was co-cultured with K562-CD19 cells that stably expressed the reporter gene encoding firefly luciferase (FLuc) for 15 h to assess the killing activity using a luciferase-mediated bioluminescence imaging assay. These clones were then stimulated with a fluorescently labeled CD19 protein for an hour. The change in CAR localization was determined via analyzing the intensity, area, and distribution (spot counts) of CAR expression in detail using a MI-FCM. The antitumor activity of some clones of CAR T-cells in vivo using a xenotransplantation model. NOG mice were injected intravenously with the CD19 positive human B-cell precursor leukemia cell line (NALM6) transfected with the FLuc reporter gene was also determined. Each CAR T-cell clone (5×106) cells was injected intravenously seven days after NALM6 injection. To assess antitumor activity, tumor volume was quantified using the IVIS imaging system to detect luminescent intensity.
Results: We found CAR molecules on cell surface aggregates in the immune response and detected the concentration as a decrease in CAR expression area. The percentage of CAR T-cells with single-spot CAR concentration was significantly correlated with cytotoxic activity (Pearson R = 0.83). We also confirmed that the clone with a higher percentage could demonstrate antitumor response and prolong the survival in xenotransplantation mouse models compared with non-treated mice, whereas the clone with the lowest percentage did not show these effects. We also confirmed that this method could be applied to CAR T-cell therapy products.
Conclusions: Quantifying the superficial CAR T-cell concentration using MI-FCM could be useful for evaluating their immune function.
The Efficacy and Safety of Obinutuzumab with Zanubrutinib As First-Line Treatment in Older Patients with Mantle Cell Lymphoma
Authors: Zhu Yanan , Lv Yunfei , Ye Xingnong , Wei Juying , Sheng Lixia , Lin Ying , Zhang Xiang , Zhang Xuewu , Tong Hongyan , Jin Jie , Yu Wen-Juan 
Published: December 2024

Backgroud: Mantle cell lymphoma (MCL) is a heterogeneous malignancy and its incidence increases with age. Elder patients have poor performance status and low tolerance to chemotherapy, so many investigators look for chemo-free therapeutic approaches for newly diagnosed elderly MCL patients.
Aims: This study aims to investigate the efficacy and safety of a combination of obinutuzumab plus zanubrutinib (GZ) in previously untreated elderly patients with MCL.
Methods: Elderly patients (age ≥ 65 years) with newly diagnosed MCL were enrolled in this open-label, multicenter, single-arm, phase II clinical trial (ChiCTR2300071433), blastoid or pleomorphic histology were excluded. Patients received obinutuzumab (1000mg, intravenously, on days 1, 8, and 15 of cycle 1 and day 1 of cycle 2-4, 4 weeks per cycle), and zanubrutinib (160 mg twice daily, orally, from cycle 2) as induction therapy. Patients achieved complete remission (CR) were followed by zanubrutinib maintenance. Patients achieved partial remission (PR) received obinutuzumab for another 2 cycles and then zanubrutinib maintenance. Zanubrutinib was administered until disease progression or unacceptable toxicity or any other reasons of discontinuation. The primary endpoint was complete response rate (CRR). The secondary endpoints were overall response rate (ORR), overall survival (OS), progression free survival (PFS) and safety profiles.
Results: 19 patients were enrolled with a median age of 72 years. 14 patients had bone marrow involvement. High mantle cell lymphoma international prognostic index (MIPI) risk score was observed in 7 patients, and 10 patients had ki-67≥30%. 1 patient had a history of atrial fibrillation. Next-generation sequencing results were available in 15 patients, and detected 4 (26.7%) TP53 mutation. 9 patients had finished induction therapy, with 8 (88.9%) achieved CR, 1 achieved PR, and the ORR was 100%. With a median follow-up of 7 months, no patients had disease progression.
Most adverse events (AEs) were grade 1-2. 2 patients had grade 2 infusion-related response during the first obinutuzumab dose, each developed grade 3 or grade 4 thrombocytopenia, and both recovered in a week. 1 patient had grade 3 anemia, 1 patient had Covid-19 infection along with paroxysmal atrial fibrillation. No bleeding was observed. No patient discontinued therapy.
Conclusion: Obinutuzumab plus zanubrutinib demonstrated a favorable efficacy and a manageable safety profile in elderly patients with untreated MCL.
The Use of ATP-Release Identifies Platelet Function Disorders in Patients with Bleeding Disorder of Unknown Cause (BDUC) and Normal LTA Results
Authors: Monard Amaury , Van Dellen Floris , Hellenbrand Dave , Verhezen Paul , Beckers Erik AM , Henskens Yvonne , Moenen Floor CJI 
Published: December 2024

Background:
About 60-70% of patients that are referred to a medical specialist with an increased bleeding tendency remain undiagnosed after extensive laboratory testing. These patients are classified as having a Bleeding Disorder of Unknown Cause (BDUC). The golden standard for the assessment of platelet function is light transmission aggregometry (LTA), but this technique is not able to detect all platelet granule defects. Therefore, the aim of this study was to investigate the additional diagnostic value of lumi-aggregomtery/ATP-release on top of LTA in patients with an increased bleeding tendency, to test for dense granule secretion disorders.
Methods:
Data from 336 patients in the ProBe-AHP study, including patients referred for analysis of an increased bleeding tendency, were used. The CHRONO-LOG® 490 4+4 light transmission aggregometer was used to perform LTA and the CHRONO-LOG® model 700 lumi- aggregometer was used to measure ATP-release by luminometry. LTA was performed according to the consensus SSC ISTH document by Cattaneo et al. For ATP-release, collagen, epinephrine and an thromboxane A2 analogue (U46619) were used as agonists. An abnormal LTA outcome was defined as more than one abnormal agonists and an abnormal ATP-release outcome was defined as one or more abnormal agonists. Other clinical and laboratory pre-existing data, including medical history, ISTH-BAT score and routine coagulation tests, were available.
Results:
In 274/336 patients LTA was performed and in 74/274 patients, additional ATP-release was done. LTA showed abnormal results in 41/274 (15%) of the patients and ATP-release showed abnormal results in 13/74 (18%) of the patients. Within the group of 74 patients in whom LTA and ATP-release was performed, initially 41 patients were diagnosed with BDUC, 15 patients with no bleeding disorder (NBD), 13 patients with a PFD (based on LTA), 1 patient with hyperfibrinolysis, 3 patients with von Willebrands disease type 1 and 1 patient with a mild FVII deficiency. After the performance of ATP-release, 10 additional diagnoses of PFD were made within the group of patients that were diagnosed with BDUC (n=10/41). This implicates a diagnostic yield of 24% with the use of additional ATP-release on top of LTA in this relatively small group of BDUC-patients.
Conclusion:
Our study showed that the addition of ATP-release testing to the diagnostic algorithm for patients with an increased bleeding tendency leads to more diagnoses of platelet function disorders, reducing the number of patients that are classified as having BDUC. Therefore, and in line with recommendations from previous studies, it is advised to perform platelet dense granule tests on top of LTA, if available, in patients with in an increased bleeding tendency.