bluuebunny/crossref_metadata_2025_split huggingface dataset:
Seismic partitioned fragility analysis for high‐rise RC chimney considering multidimensional ground motion
Authors: Zhou Changdong , Tian Miaowang , Guo Kunpeng 
Published: November 2018

SummaryIn order to identify the vulnerable parts and areas of the high‐rise reinforced concrete chimney, this paper presents an effective method, which called partitioned fragility analysis. One 240‐m‐high reinforced concrete chimney was selected as the practical project, and its analytical model was created with ABAQUS software. The selected high‐rise chimney structure was divided into 17 parts, and then the damage probability of each part in different damage states was obtained with the fragility analysis considering multidimensional ground motions. Twenty ground motion records were taken from the Next Generation Attenuation database as the input motions, and the peak ground acceleration was selected as the intensity measure. The response of the chimney structure under multidimensional ground motions was obtained based on incremental dynamic analysis. The maximum strains of concrete and steel bars were defined as the damage limit states of the chimney structure. The fragility curves and surfaces obtained from this analysis showed that the vulnerable areas of the chimney structure appear at 0–20 m, 90–130 m, and 150–200 m along the height of the chimney respectively. Based analytical results, these vulnerable parts can be retrofitted to enhance the seismic resistance of existing chimney structures. And the partitioned fragility analysis method can also be used to improve the design of new chimney structures.
Seismic design and assessment of structures with viscous dampers at limit state levels: Focus on probability of damage in devices
Authors: Sepehri Ahmad , Taghikhany Touraj , Ahmadi Namin Seyed Mohammad Reza 
Published: November 2018

SummaryDuring large earthquakes, the seismic demand of viscous dampers may exceed their capacity. In this regard, current design codes must consider extreme conditions and preserve the damper at limit state levels. Here, by adjusting the damping coefficient, a procedure is introduced to mitigate device damages during severe earthquakes. To assess the procedure, 15 special moment resisting frames with a different number of stories (two, four, and eight) were designed by three methods: The recommended novel procedure, the seismic provisions of ASCE7, and the procedure proposed by Miyamoto et al. for structures, installed with supplemental damping devices. A series of incremental dynamic analyses were then performed by modeling the limit state behavior of viscous dampers. Results indicated that the novel method reduces the damage probability of dampers as well as the maximum demands on the structure at different seismic hazard levels.
Lung Adenocarcinoma has a Higher Risk of Lymph Node Metastasis than Squamous Cell Carcinoma: A Propensity Score‐Matched Analysis
Authors: Deng Han‐Yu , Zeng Miao , Li Gang , Alai Guha , Luo Jun , Liu Lun‐Xu , Zhou Qinghua , Lin Yi‐Dan 
Published: November 2018

AbstractBackgroundControversy still exists in which subtype of non‐small‐cell lung cancer [squamous cell carcinoma (SCC) or adenocarcinoma] is more likely to have lymph node (LN) metastasis. The aim of this study is to compare the pattern of LN metastasis in two cohorts of matched patients surgically treated for SCC or adenocarcinoma.MethodsA retrospective analysis of patients undergoing lobectomy or segmentectomy with systematic lymphadenectomy without preoperative treatment for lung SCC or adenocarcinoma was conducted in this study. Data for analysis consisted of age, gender, tumor size, lobe‐specific tumor location, tumor location (peripheral or central), and pathologic findings. We conducted the propensity score‐matched (PSM) analysis to eliminate potential bias effects of possible confounding factors.ResultsFrom January 2015 to December 2016 in our department, we finally included a total of 387 patients (including 63 patients with SCC and 324 patients with adenocarcinoma) for analysis. For the unmatched cohort, there was no sufficient evidence of significantly different number of positive LNs (P = 0.90) and rate of LN metastasis (P = 0.23) between SCC patients and adenocarcinoma patients. However, potential confounding factors, for example gender, tumor size, tumor location, tumor differentiation, and total number of dissected LNs, were significantly different between patients with SCC and those with adenocarcinoma. In the analysis of matched cohort after PSM analysis, those above confounding factors were comparable between the two groups. However, patients with adenocarcinoma had significantly more mean positive LNs (2.2 and 0.7; P = 0.008) and a higher rate of LN metastasis (53% and 29%; P = 0.016) than those with SCC.ConclusionsLung adenocarcinoma had a higher risk of LN metastasis than SCC, suggesting that different therapeutic modalities may be indicated for the two different subtypes of lung cancer.
Indications and Outcomes of a Cross‐Linked Porcine Dermal Collagen Mesh (Permacol) for Complex Abdominal Wall Reconstruction: A Multicenter Audit
Authors: Doussot Alexandre , Abo‐Alhassan Fawaz , Derbal Sofiane , Fournel Isabelle , Kasereka‐Kisenge Faustin , Codjia Tatiana , Khalil Haitham , Dubuisson Vincent , Najah Haythem , Laurent Alexis , Romain Benoît , Barrat Christophe , Trésallet Christophe , Mathonnet Muriel , Ortega‐Deballon Pablo 
Published: November 2018

AbstractIntroductionTo reduce the occurrence of complications in the setting of high‐risk patients with contaminated operative field, a wide range of biologic meshes has been developed. Yet, few series have reported outcomes after abdominal wall repair (AWR) using such meshes. Permacol is an acellular porcine dermal collagen matrix with a cross‐linked pattern. This study reports short‐ and long‐term outcomes after AWR for incisional hernia using Permacol.Materials and methodsAll consecutive patients undergoing single‐stage open AWR using Permacol mesh at eight university hospitals were included. Mortality, complication and hernia recurrence rates were assessed. Independent risk factors for complications and hernia recurrence were identified with logistic regression and Fine and Gray analysis, respectively.ResultsOverall, 250 patients underwent single‐stage AWR with Permacol. Nearly 80% had a VHWG grade 3 or 4 defect. In‐hospital mortality and complication rates were 4.8% (n = 12) and 61.6% (n = 154), respectively. Reintervention for complications was required for 74 patients (29.6%). Mesh explantation rate was 4% (n = 10). Independent risk factors for complications were smoking, defect size and VHWG grade. After a mean follow‐up time of 16.8 months (± 18.1 months), 63 (25.2%) experienced hernia recurrence. One‐, 2‐ and 3‐year RFS were 90%, 74% and 57%, respectively. Previous AWR, mesh location and the need for reintervention were independent predictors of hernia recurrence.DiscussionSingle‐stage AWR is feasible using Permacol. Mortality and complication rates are high due to patients’ comorbidities and the degree of contamination of the operative field. Given the observed recurrence rate, the benefit of biologics remains to be ascertained.
Treatment of chronic heart failure in the 21st century: A new era of biomedical engineering has come
Authors: Hu Chun‐Song , Wu Qing‐Hua , Hu Da‐Yi , Tkebuchava Tengiz 
Published: November 2018

AbstractChronic heart failure (CHF) is a challenging burden on public health. Therapeutic strategies for CHF have developed rapidly in the past decades from conventional medical therapy, which mainly includes administration of angiotensin‐converting enzyme inhibitors, angiotensin receptor blockers, beta‐blockers, and aldosterone antagonists, to biomedical engineering methods, which include interventional engineering, such as percutaneous balloon mitral valvotomy, percutaneous coronary intervention, catheter ablation, biventricular pacing or cardiac resynchronization therapy (CRT) and CRT‐defibrillator use, and implantable cardioverter defibrillator use; mechanical engineering, such as left ventricular assistant device use, internal artery balloon counterpulsation, cardiac support device use, and total artificial heart implantation; surgical engineering, such as coronary artery bypass graft, valve replacement or repair of rheumatic or congenital heart diseases, and heart transplantation (HT); regenerate engineering, which includes gene therapy, stem cell transplantation, and tissue engineering; and rehabilitating engineering, which includes exercise training, low‐salt diet, nursing, psychological interventions, health education, and external counterpulsation/enhanced external counterpulsation in the outpatient department. These biomedical engineering therapies have greatly improved the symptoms of CHF and life expectancy. To date, pharmacotherapy, which is based on evidence‐based medicine, large‐scale, multi‐center, randomized controlled clinical trials, is still a major treatment option for CHF; the current interventional and mechanical device engineering treatment for advanced CHF is not enough owing to its individual status. In place of HT or the use of a total artificial heart, stem cell technology and gene therapy in regenerate engineering for CHF are very promising. However, each therapy has its advantages and disadvantages, and it is currently possible to select better therapeutic strategies for patients with CHF according to cost‐efficacy analyses of these therapies. Taken together, we think that a new era of biomedical engineering for CHF has begun.
Applying a meal coding system to 16-d weighed dietary record data in the Japanese context: towards the development of simple meal-based dietary assessment tools
Authors: Murakami Kentaro , Livingstone M. Barbara E. , Sasaki Satoshi , Hirota Naoko , Notsu Akiko , Miura Ayako , Todoriki Hidemi , Fukui Mitsuru , Date Chigusa 
Published: November 2018

AbstractData on the combination of foods consumed simultaneously at specific eating occasions are scarce, primarily due to a lack of assessment tools. We applied a recently developed meal coding system to multiple-day dietary intake data for assessing its ability to estimate food and nutrient intakes and characterise meal-based dietary patterns in the Japanese context. A total of 242 Japanese adults completed sixteen non-consecutive-day weighed dietary records, including 14 734 eating occasions (3788 breakfasts, 3823 lunches, 3856 dinners and 3267 snacks). Common food group combinations were identified by meal type to identify a range of generic meals. Dietary intake was calculated on the basis of not only the standard food composition database but also the substituted generic meal database. In total, eighty generic meals (twenty-three breakfasts, twenty-one lunches, twenty-four dinners and twelve snacks) were identified. The Spearman correlation coefficients between food group intakes calculated based on the standard food composition database and the substituted generic meal database ranged from 0·26 to 0·85 (median 0·69). The corresponding correlations for nutrient intakes ranged from 0·17 to 0·82 (median 0·61). A total of eleven meal patterns were established using principal components analysis, and these accounted for 39·1 % of total meal variance. Considerable variation in patterns was seen in meal type inclusion and choice of staple foods (bread, rice and noodles) and drinks, and also in meal constituents. In conclusion, this study demonstrated the usefulness of a meal coding system for assessing habitual diet, providing a scientific basis towards the development of simple meal-based dietary assessment tools.
Control of Plasmodium vivax malaria by mass chemoprevention with primaquine
Authors: Kim Hyon-Ok , Ko Tong-Chan , Kim Song-Su , Im Song-Guk , Kim Yun-Nam 
Published: November 2018

Abstract
In Democratic People's Republic of Korea, only Plasmodium vivax malaria is prevalent, which is divided into two forms – long incubation form and short form. Among malaria cases reported in a year, long form accounts for 69% and short form 31%. Incubation period of short form ranges from 10 to 29 days (average 17 days) and long from 5·5 to 16 months (average 8–13 months). The most relapses (90%) were reported from May to September – malaria transmission season in the country. Result from preliminary mass chemoprevention in small size of population before transmission season to find appropriate method showed high protective efficacy in two regimens – one regimen given primaquine 0·25 mg base kg−1 day−1 for 14 days (95%) and another 0·5 mg base kg−1 day−1 for 7 days (94%). During the mass chemoprevention with primaquine, some adverse effects were reported but transient. We consider that mass chemoprevention with primaquine before transmission season is of great significance in disturbing the vivax malaria transmission, in which long incubation form is predominant in countries prevailing seasonal malaria.
Influence of Different Acid Treatments on the Radiocarbon Content Spectrum of Sedimentary Organic Matter Determined by RPO/Accelerator Mass Spectrometry
Authors: Bao Rui , McNichol Ann P , Hemingway Jordon D , Lardie Gaylord Mary C , Eglinton Timothy I 
Published: November 2018

ABSTRACTIn practice, obtaining radiocarbon (14C) composition of organic matter (OM) in sediments requires first removing inorganic carbon (IC) by acid-treatment. Two common treatments are acid rinsing and fumigation. Resulting14C content obtained by different methods can differ, but underlying causes of these differences remain elusive. To assess the influence of different acid-treatments on14C content of sedimentary OM, we examine the variability in14C content for a range of marine and river sediments. By comparing results for unacidified and acidified sediments [HCl rinsing (RinseHCl) and HCl fumigation (FumeHCl)], we demonstrate that the two acid-treatments can affect14C content differentially. Our findings suggest that, for low-carbonate samples, RinseHClaffects the Fm values due to loss of young labile organic carbon (OC). FumeHClmakes the Fm values for labile OC decrease, leaving the residual OC older. High-carbonate samples can lose relatively old organic components during RinseHCl, causing the Fm values of remaining OC to increase. FumeHClcan remove thermally labile, usually young, OC and reduce the Fm values. We suggest three factors should be taken into account when using acid to remove carbonate from sediments: IC abundance, proportions of labile and refractory OC, and environmental matrix.
Trichostatin A inducesTrypanosoma cruzihistone and tubulin acetylation: effects on cell division and microtubule cytoskeleton remodelling
Authors: de Oliveira Santos Jean , Zuma Aline Araujo , de Luna Vitorino Francisca Nathalia , da Cunha Julia Pinheiro Chagas , de Souza Wanderley , Motta Maria Cristina M. 
Published: November 2018

AbstractTrypanosoma cruzi, the causative agent of Chagas disease, is a public health concern in Latin America. Epigenetic events, such as histone acetylation, affect DNA topology, replication and gene expression. Histone deacetylases (HDACs) are involved in chromatin compaction and post-translational modifications of cytoplasmic proteins, such as tubulin. HDAC inhibitors, like trichostatin A (TSA), inhibit tumour cell proliferation and promotes ultrastructural modifications. In the present study, TSA effects on cell proliferation, viability, cell cycle and ultrastructure were evaluated, as well as on histone acetylation and tubulin expression of theT. cruziepimastigote form. Protozoa proliferation and viability were reduced after treatment with TSA. Quantitative proteomic analyses revealed an increase in histone acetylation after 72 h of TSA treatment. Surprisingly, results obtained by different microscopy methodologies indicate that TSA does not affect chromatin compaction, but alters microtubule cytoskeleton dynamics and impair kDNA segregation, generating polynucleated cells with atypical morphology. Confocal fluorescence microscopy and flow cytometry assays indicated that treated cell microtubules were more intensely acetylated. Increases in tubulin acetylation may be directly related to the higher number of parasites in the G2/M phase after TSA treatment. Taken together, these results suggest that deacetylase inhibitors represent excellent tools for understanding trypanosomatid cell biology.
How bureaucratic leadership shapes policy outcomes: partisan politics and affluent citizens’ incomes in the American states
Authors: Berkowitz Daniel , Krause George A. 
Published: November 2018

AbstractWe maintain that political institutions’ policy objectives are best met under conditions when they are unified, and also when their administrative leadership is effective. We apply this argument to the understanding of how unified Democratic and Republican governments in the American states have influenced the incomes of affluent citizens. We find that affluent income gains occur under unified Republican state governments when compensation to executive agency heads is sufficiently high. These income gains are notable relative to both divided and unified partisan control of state governments. The evidence highlights the asymmetric role that bureaucratic leadership plays in attaining policy outcomes consistent with political institutions’ policy preferences, while underscoring the limits of electoral institutions to shape policy outcomes of their own accord. Efforts to lower the capacity of the administrative leadership constrain unified political institutions from converting their policy objectives into policy outcomes.
‘We walk, we laugh, we dance’: refugee experiences of older Chin women in Kuala Lumpur
Authors: Lamb Nicole , Hoffstaedter Gerhard 
Published: November 2018

AbstractOlder persons are among the most vulnerable of refugees seeking protection in Malaysia, yet seldom are they the focus of the work of the United Nations High Commissioner for Refugees, local charities or non-government organisations. In-depth ethnographic research with a group of older Chin women in Kuala Lumpur demonstrates both the vulnerability and resilience of older refugees in urban environments. Older refugees play a crucial role in sustaining families and communities. They provide much-needed support to refugee communities who struggle to meet the needs of everyday life in the absence of protection protocols.
Duration of untreated illness in a cross-diagnostic sample of obsessive-compulsive disorder, panic disorder, and social anxiety disorder
Authors: Vigne Paula , Fortes Pedro , Dias Rafaela V. , Laurito Luana D. , Loureiro Carla P. , de Menezes Gabriela B. , Stangier Ulrich , Fontenelle Leonardo F. 
Published: November 2018

ObjectiveIn this study, we compared duration of untreated illness (DUI) in obsessive-compulsive disorder (OCD), panic disorder (PD), and social anxiety disorder (SAD) patients and investigated its correlates, both within specific diagnoses and across the whole sample.MethodsEighty-eight patients (33 OCD, 24 SAD, and 31 PD) had their diagnosis confirmed by the Mini International Neuropsychiatric Interview, were assessed for treatment-seeking variables, and were evaluated with instruments aimed at quantifying transdiagnostic features (i.e., the Cause subscale of the Illness Perception Questionnaire–Mental Health and the Anxiety Sensitivity Index–Revised) and severity of illness (i.e., Beck Depression and Anxiety Inventories, the Dimensional Obsessive-Compulsive Scale, the Panic and Agoraphobia Scale, and the Social Phobia Inventory).ResultsThe only differences between groups with short (<2 years) versus long (>2 years) DUI were greater fear of public display of anxiety in the first group and greater social avoidance in the second group. The DUI was significantly different between groups that sought treatment after the onset of illness, with OCD patients having longer DUI than PD patients and shorter DUI than SAD patients. Further, DUI correlated negatively with the perception of OCD being caused by stress and positively with severity of panic-related disability in SAD patients, but not in PD or OCD patients.ConclusionThere was substantial delay in treatment seeking among the anxiety and obsessive-compulsive disorder patients, particularly those with OCD or SAD. Perception of stress as a cause of OCD prompted treatment seeking, while severity of panic symptoms delayed treatment seeking.
Can Closed-mindedness be an Intellectual Virtue?
Authors: Battaly Heather 
Published: November 2018

AbstractIs closed-mindedness always an intellectual vice? Are there conditions in which it might be an intellectual virtue? This paper adopts a working analysis of closed-mindedness as an unwillingness or inability to engage seriously with relevant intellectual options. In standard cases, closed-mindedness will be an intellectual vice. But, in epistemically hostile environments, closed-mindedness will be an intellectual virtue.
On Anger, Silence, and Epistemic Injustice
Authors: Bailey Alison 
Published: November 2018

AbstractIf anger is the emotion of injustice, and if most injustices have prominent epistemic dimensions, then where is the anger in epistemic injustice? Despite the question my task is not to account for the lack of attention to anger in epistemic injustice discussions. Instead, I argue that a particular texture of transformative anger – a knowing resistant anger – offers marginalized knowers a powerful resource for countering epistemic injustice. I begin by making visible the anger that saturates the silences that epistemic injustices repeatedly manufacture and explain the obvious: silencing practices produce angry experiences. I focus on tone policing and tone vigilance to illustrate the relationship between silencing and angry knowledge management. Next, I use María Lugones's pluralist account of anger to bring out the epistemic dimensions of knowing resistant anger in a way that also calls attention to their histories and felt textures. The final section draws on feminist scholarship about the transformative power of angry knowledge to suggest how it might serve as a resource for resisting epistemic injustice.
Healthcare Practice, Epistemic Injustice, and Naturalism
Authors: Kidd Ian James , Carel Havi 
Published: November 2018

AbstractIll persons suffer from a variety of epistemically-inflected harms and wrongs. Many of these are interpretable as specific forms of what we dubpathocentric epistemic injustices, these being ones that target and track ill persons. We sketch the general forms of pathocentric testimonial and hermeneutical injustice, each of which are pervasive within the experiences of ill persons during their encounters in healthcare contexts and the social world. What's epistemically unjust might not be only agents, communities and institutions, but the theoretical conceptions of health that structure our responses to illness. Thus, we suggest that although such pathocentric epistemic injustices have a variety of interpersonal and structural causes, they are also sustained by a deeper naturalistic conception of the nature of illness.
Back-testing the chain-ladder method
Authors: Gabrielli Andrea , Wüthrich Mario V. 
Published: November 2018

AbstractThe chain-ladder method is one of the most popular claims reserving techniques. The aim of this study is to back-test the chain-ladder method. For this purpose, we use a stochastic scenario generator that allows us to simulate arbitrarily many upper claims reserving triangles of similar characteristics for which we also know the corresponding lower triangles. Based on these simulated triangles, we analyse the performance of the chain-ladder claims reserving method.