bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tratamiento farmacológico del conducto arterioso permeable en recién nacidos prematuros
Authors: Escobar Hellmann Adrián , Meneses-Gaviria Gyhill , Revelo-Jurado Nataly , Villa-Rosero Julián Felipe , Ijají Piamba Jhon Edison , Burbano-Imbachí Alexander , Cedeño-Burbano Anuar Alonso 
Published: July 2019

Introducción. Por lo general, el manejo farmacológico del conducto arterioso permeable (CAP) comprende inhibidores no selectivos de la enzima ciclooxigenasa, en especial indometacina e ibuprofeno. En años recientes también se ha sugerido al acetaminofén como alternativa terapéutica.Objetivo. Realizar una revisión narrativa de la literatura acerca del manejo farmacológico del CAP.Materiales y métodos. Se realizó una búsqueda estructurada de la literatura en las bases de datos ProQuest, EBSCO, ScienceDirect, PubMed, LILACS, Embase, Trip Database, SciELO y Cochrane Library con los términos “Ductus Arteriosus, patent AND therapeutics”; “Ductus Arteriosus, patent AND indometacin”; “Ductus Arteriosus, Patent AND ibuprofen”, y “Ductus Arteriosus, patent AND acetaminophen”. La búsqueda se hizo en inglés con sus equivalentes en español.Resultados. Se encontraron 69 artículos con información relevante para llevar a cabo la presente revisión.Conclusiones. En neonatos prematuros, la base del tratamiento farmacológico del CAP continúa siendo los inhibidores no selectivos de la ciclooxigenasa, indometacina e ibuprofeno, ambos con perfiles similares de seguridad y eficacia. La evidencia disponible sugiere que el acetaminofén podría constituir una alternativa útil para el manejo, pero resulta insuficiente para realizar recomendaciones definitivas respecto a la eficacia y seguridad de este medicamento.
Manejo perioperatorio de niños con infección respiratoria superior
Authors: Corrales-Zúñiga Norma Constanza , Martínez-Muñoz Nelly Patricia , Realpe-Cisneros Sara Isabel , Pacichana-Agudelo Carlos Eberth , Realpe-Cisneros Leandro Guillermo , Cerón-Bastidas Jorge Armando , Molina Bolaños Jaime Alexander , Cedeño-Burbano Anuar Alonso 
Published: July 2019

Introducción. Es frecuente que muchos niños sometidos a procedimientos con anestesia general tengan historia de infección viral respiratoria superior reciente o activa.Objetivo. Realizar una revisión narrativa acerca de las pautas de manejo anestésico para los niños con infección reciente o activa de la vía aérea superior.Materiales y métodos. Se realizó una búsqueda estructurada de la literatura en las bases de datos ProQuest, EBSCO, ScienceDirect, PubMed, LILACS, Embase, Trip Database, SciELO y Cochrane Library con los términos Anesthesia AND Respiratory Tract Infections AND Complications; Anesthesia AND Upper respiratory tract infection AND Complications; Anesthesia, General AND Respiratory Tract Infections AND Complications; Anesthesia, General AND Upper respiratory tract infection AND Complications; Anesthesia AND Laryngospasm OR Bronchospasm. La búsqueda se hizo en inglés con sus equivalentes en español.Resultados. Se encontraron 56 artículos con información relevante para el desarrollo de la presente revisión.Conclusiones. Una menor manipulación de la vía aérea tiende a disminuir la frecuencia de aparición y severidad de eventos adversos respiratorios perioperatorios. No existe evidencia suficiente para recomendar la optimización medicamentosa en pacientes con infección respiratoria superior.
¿Por qué la rehabilitación respiratoria no llega a todos los pacientes de enfermedad pulmonar obstructiva crónica que lo necesitan? Revisión de la literatura
Authors: Rigo Aina , Paz-Lourido Berta 
Published: July 2019

Introducción. La rehabilitación respiratoria (RR) es un tratamiento clave en la enfermedad pulmonar obstructiva crónica, pero aun estando disponible, los pacientes no siempre acceden a ella.Objetivo. Identificar los factores que pueden limitar el acceso a la RR y que se relacionan con los pacientes, los médicos y los fisioterapeutas.Materiales y métodos. Se realizó una revisión de artículos publicados en inglés y español entre 2006 y 2018. Se usaron los términos “COPD”, “chronic obstructive pulmonary disease”, “COLD”, “chronic obstructive lung disease”, “physical therapy modalities”, “rehabilitation”, “health services accessibility” y “patient” en las bases de datos PubMed, PEDro, Scielo e IBECS.Resultados. Se seleccionaron 11 publicaciones. Entre las barreras que afectan a los pacientes destacan el transporte, la condición ambiental, las situaciones personales y algunos factores sociales y contextuales. El conocimiento de los profesionales, sus condiciones de trabajo y sus expectativas sobre beneficio de los protocolos de RR también son factores que condicionan el acceso de los pacientes.Conclusiones. La formación interprofesional de médicos y fisioterapeutas, la implantación de protocolos flexibles a las condiciones de los pacientes y las medidas organizativas e intersectoriales del sistema sanitario pueden facilitar la accesibilidad a la RR de los pacientes.
Modified radical mastoidectomy in children: mastoid cavity problem and its management
Authors: Dutta Heempali Das , Rayamajhi Pabina , Dutta Deepak 
Published: July 2019

<p class="abstract"><strong>Background:</strong> Various factors are responsible for post MRM chronically discharging mastoid cavity which has to be identified and treated properly so as to avoid further complications. The aim of this study is to evaluate the causative factors responsible for persistent ear discharge in post mastoidectomy cases and their management in paediatric age group.</p><p class="abstract"><strong>Methods:</strong> This is a cross sectional study done from May 2013 to April 2017 in the Paediatric ENT unit of Department of ENT &amp; HNS, TUTH, Kathmandu, Nepal. Children were evaluated for persistent ear discharge and managed for one year. Risk factors like high facial ridge, inadequate meatoplasty, unepithelize mastoid cavity, tympanic membrane perforation and residual or recurrent choleateatoma, infections, nasal or nasopharngeal pathology were evaluated and treated. Outcome of management was measured in terms of achieving dry mastoid cavity over one year period. </p><p class="abstract"><strong>Results:</strong> A total of 92 post MRM children with persistent discharge were included in the study. 33/92 (35.8%) had anatomical defects. Four cases had recurrent or residual cholesteatoma. 22/92 (23.9%) of the cases had granulation and infection. 14 cases had nasophayngeal inflammation and 13 cases had recurrent accumulation of wax or debris. After the treatment of various factors, 43/75 (53.7%) ear became dry within 3 months, 22/75 (29%) ear became dry within 6 months, 6/75 had persistent discharge even 1 year after treatment. Whereas, in 5/75 (13.4%) had on and off discharge.</p><p class="abstract"><strong>Conclusions:</strong> The chronically discharging mastoid cavity can be well managed by early identification of causative factors.</p>
<strong>Conhecimentos dos estudantes de medicina a respeito da triagem citológica do câncer de colo uterino</strong>
Authors: Figueiredo Alves Rosane Ribeiro , Oliveira Tábata Silva de Oliveira Silva , Faleiro Naiane Quintilhano 
Published: July 2019

Introdução. O câncer do colo uterino, apesar de importante problema de saúde pública, é passível de prevenção. O Ministério da Saúde faz recomendações para o rastreamento citológico, publicadas em 2011 e atualizadas em 2016. Objetivo. Avaliar o conhecimento dos estudantes de medicina sobre a epidemiologia e rastreamento do câncer do colo uterino. Métodos. Estudo de corte transversal, realizado de setembro de 2017 a junho de 2018, envolvendo alunos do curso de medicina da Pontifícia Universidade Católica de Goiás (PUC-GO). Os dados foram obtidos por meio de questionário, contendo 21 questões, com duas alternativas cada, respondido sem consulta. O conhecimento dos alunos foi categorizado em nível 1 quando menos de 50% das respostas corretas, nível 2 com 51% a 70% corretas e nível 3, com 71% a 100% corretas. Analisou-se a diferença entre os níveis de conhecimento considerando, categoria 1 alunos do quinto ano do curso e categoria 2 do sexto ano. Aplicou-se o teste qui-quadrado (X2) para análise comparativa. As diferenças foram consideradas estatisticamente significativas com o valor de p menor que 0,05. Resultados. A média de acertos acima de 70% foi significativamente maior para alunos do sexto ano (p< 0,001). Das questões sobre a epidemiologia, rastreio de doenças e desempenho da triagem citológica, a frequência de acertos entre alunos do quinto e sexto ano não apresentou diferença significativa. Das dez questões sobre conhecimentos das Diretrizes Brasileiras para Rastreio do Câncer de Colo Uterino, houve diferença estatisticamente significativa nas questões número catorze, dezessete, dezenove e vinte, com valores de p 0,017; 0,017; 0,006; e menor que 0,001, respectivamente. O percentual de acertos para a maioria das questões foi menor que 70%. Conclusão. Alunos do sexto ano apresentaram nível de conhecimento significantemente maior comparado aos alunos do quinto ano, embora insuficiente para ambos. Palavras-chave: câncer de colo de útero. Exame colpocitológico. Estudantes de medicina.
Apoptosis Inductionof Armeniacae Semen Extractin Human Acute Leukemia (NALM-6 and KG-1) Cells
Authors: Mosadegh Manshadi Shiva , Safavi Maliheh , Rostami Shahrbano , Nadali Fatemeh , Shams Ardekani Mohammad Reza 
Published: July 2019

Background: Prunusarmeniaca is a member of the Rosacea family. The most important ingredient of this family is amygdalin that is believed to have anti-tumor and analgesic properties. The aim of this study was to evaluate the anti-proliferative effects of Armeniacae semen extract on the acute leukemia, NALM-6, and KG-1 cell lines, and investigate the effect of the extract on apoptosis of these cell lines and caspase-3 gene expression.
Materials and Methods: We prepared aqueous, ethyl acetate, and hydro alcoholic extracts of the Armeniacae semen. The NALM-6 and KG-1 cell lines and mononuclear cells (PBMCs) of healthy controls were treated with different doses of the extracts for 48 hours, and then cell viability was investigated with the MTT test. High-Performance Liquid Chromatography was done for amygdalin identification. The percentage of apoptotic cells was determined using the Annexin V-FITC/PI flow cytometric kit, and caspase-3 gene expression was evaluated.
Results: MTT test revealed that the strongest Inhibition Concentration (IC50) in KG-1 and NALM-6 cell lines was related to the ethyl acetate extract. This extract did not have toxic effects on PBMCs. Flow cytometric analysis showed that the ethyl acetate extract at its IC50 concentration led to almost 50% apoptosis in both cell lines after 48 hours. In the molecular examination, after treatment, a significant increase was seen in caspase-3 gene expression in NALM6 and KG1 cells compared to the control (P<0.001 and P <0.05, respectively).
Conclusion: Our data confirmed that the ethyl acetate extract of Prunusarmeniaca could reduce the proliferation of KG-1 and NALM-6 cell lines probably by activating the apoptotic pathway.
STAYING DECISION MAKING PROCESS IN DISASTER PRONE AREA: A GROUNDED THEORY METHOD STUDY ON FISHERMEN COMMUNITY IN SEMARANG COAST, INDONESIA
Authors: Amin Choirul , . Sukamdi , . Rijanta 
Published: July 2019

Purpose of the Study: In an increasing migration driven by climate change disaster, there are people who remain to stay in disaster-prone areas. Even though there is little research on migration to understand non-migrant people, this study seeks to understand the staying decision making process and understand how and why people stay in disaster-prone areas.
Methodology: Grounded Theory Method (GTM) is used in this research. The qualitative approach in this study is intended to gain individual insights to reveal the process and steps of staying decision-making in disaster prone-areas.
Applications: This study was conducted in the Semarang coastal area, which is simultaneously prone to three disasters, i.e., sea level rise, land subsidence, and tidal inundation. The study shows that staying decision-making was taken in household units. The staying decision-making process consists of interactions between four components: availability of options, motives, expectations, and incentives.
Results: Exploring the decision to stay is an opportunity to understand migration processes in a new way. This research adds a conceptual study to the migration literature on the basis of existing theories to explain immobility in disaster-prone areas.
Prospective mathematics teachers’ argumentation structure when constructing a mathematical proof: The importance of backing
Authors: Laamena Christina Martha , Nusantara Toto 
Published: July 2019

[English]: This qualitative study with phenomenology design aims to investigate the use of backing and its relation to rebuttal and qualifier in prospective mathematics teachers’ (PMTs) argumentation when constructing a mathematical proof about algebraic function. The data were collected through subjects' works on the proof, recorded think-aloud data, and in-depth interviews. Data analysis was guided by Toulmin’s argumentation scheme. The results show that the PMTs used three types of backing, i.e., backing in the form of definitions or theorems (reference backing), examples of numbers (numerical backing) and graphs of functions (graphical backing). The PMTs utilized the backings to strengthen deductive and inductive warrant. A numerical backing is used when a warrant cannot justify the truth of a claim. Graphical backing is used to convince oneself about the truth of the data that has been made while the reference backing is only clarification when students have understood or have knowledge of the statement given. Numerical and graphical backing relate directly to rebuttal and provide counter-examples and qualifier of the claim. A numerical backing makes students more confident about claims that are generated compared to reference backing.
Keywords: Argumentation, Mathematical proof, Backing
[Bahasa]: Penelitian kualitatif dengan desain fenomenologi ini bertujuan untuk menyelidiki penggunaan backing dan hubungannya dengan rebuttal dan qualifier dalam membangun bukti matematika terkait fungsi aljabar oleh calon guru matematika. Data dikumpulkan melalui hasil kerja siswa, rekaman think aloud, dan wawancara mendalam. Analisis data merujuk pada skema argumentasi Toulmin. Hasil penelitian menunjukkan bahwa backing yang digunakan siswa tidak hanya berbentuk teorema atau definisis (reference backing) tetapi juga contoh-contoh bilangan (numerical backing) dan grafik fungsi (graphical backing). Ketiga jenis backing tersebut untuk memperkuat warrant induktif maupun deduktif. Numerical backing digunakan ketika warrant tidak dapat menjustifikasi kebenaran klaim. Graphical backing digunakan untuk meyakinkan diri sendiri tentang kebenaran klaim yang telah dibuat sedangkan reference backing hanya bersifat klarifikasi karena siswa telah memahami pernyataan yang diberikan. Numerical backing dan graphical backing berhubungan langsung dengan rebuttal untuk memberikan contoh penyangkal dan jaminan kebenaran (qualifier) klaim. Numerical backing membuat siswa lebih percaya diri tentang klaim yang dihasilkan dibandingkan dengan reference backing.
Kata kunci: Argumentasi, Bukti matematis, Backing
TINGKAT KESIAPAN KOTA SURAKARTA TERHADAP DIMENSI MOBILITAS CERDAS (SMART MOBILITY) SEBAGAI BAGIAN DARI KONSEP KOTA CERDAS (SMART CITY)
Authors: Pratiwi Alfariani , Soedwiwahjono Soedwiwahjono , Hardiana Ana 
Published: July 2019

<p><em>The city has a problem that often arises due to the construction of their own city. To prevent that, city management needs through a sustainable approach to the concept of planning. Now, the concept of smart city is developing, where several major cities in Indonesia have started implementing the concept. Surakarta be a pioneer in the use of technology of transportation commonly called Intelligent Transport Systems(ITS). Surakarta indicated to apply the concept of smart city. Together with Indosat, subsidiary of PT. Starone Partner Telecommunications (SMT) cooperate to apply the concept of smart city in Surakarta for example, e-transportation. E-transportation similar to the principle of smart mobility in the theory of smart city. Howerver not only the application of smart mobility technology, but also need to look at the aspects that provide comfort, security, and sustainability.</em></p><p><em>This study wanted to see the level of readiness of Surakarta to smart mobility dimension as part of the smart city concept. The aspects of this research are local accessibility, international accessibility, multi-modal access, information and communication technology infrastructure supporting urban mobility, sustainable transport and safety. The analytical method used in this research is the analysis technique of scoring which assess the readiness of each aspect and the overall readiness. The results showed that Surakarta belongs to the category ready but conditional on the application of smart mobility. This means Surakarta need to do several requirements either repair or procurement in some aspects. Aspects that have been prepared but has some requirements which need to be done are the aspect of local accessibility, international accessibility, multi-modal access, and information and communication technology infrastructure supporting urban mobility. Sustainable transport and safety aspects belong to the category not ready to support the implementation of smart mobility in Surakarta.</em></p><p><em> </em></p><p><strong><em>Keywords</em></strong><em>: smart city, smart mobility, smart transportation</em></p>
PROSES PERUBAHAN ARSITEKTURAL KAWASAN BERSEJARAH KAMPUNG WISATA KAUMAN SURAKARTA
Authors: Setyaningsih Wiwik , Nuryanti Wiendu , Prayitno Budi , Sarwadi Ahmad 
Published: July 2019

<p><em>K</em><em>awasan bersejarah dalam arsitektur perkotaan merupakan salah satu aset daya tarik wisata yang akan memberikan ikatan kesinambungan yang erat, antara masa lalu, masa kini dan masa mendatang.Kampung wisata, sebagai suatu kampung yang memiliki potensi keunikan fisik dan non fisik, yang dikelola secara terpadu dan terencana, sehingga siap untuk menerima kunjungan wisatawan. </em><em>Selama ini eksistensi </em><em>kawasan bersejarah yang memiliki kekentalan nilai sejarah belum ditangani dan dikelola secara optimal. Kecenderungan ini terlihat pada beberapa kawasan bersejarah yang telah kehilangan karakter aslinya, bahkan telah hilang dan berganti fungsi karena tidak terperhatikan. Maka salah satu penanganan awal adalah dengan merumuskan proses terjadinya perubahan </em><em>arsitektural kawasan bersejarah kampung wisata</em><em>. Tujuan penelitian ini, merumuskan </em><em>perubahan arsitektural kawasan bersejarah kampung wisata Kauman.Rumusan didasarkan pada metode deskriptif eksploratif, pendekatan SWOT, dan mappingspasial fisik karakter kawasan, serta mapping sosekbud melalui FGD danPRA.Hasil akhir berupa rumusan perubahan arsitektural kawasan bersejarah kampung wisata Kauman, sebagai usulan Perda untuk direkomendasikan dan disosialisasikan secara networkinguntuk ditindaklanjuti oleh stakeholder terkait secara bersama.</em></p><p> </p><p><strong><em>Kata kunci</em></strong><em> : kawasan bersejarah, kampung wisata</em></p>
KAJIAN PERENCANAAN KOTA PADA GEDUNG BEKAS RSJ MANGUNJAYAN, SRIWEDARI, SURAKARTA
Authors: Kusumastuti Kusumastuti 
Published: July 2019

<p><em>Kota dan bagian-bagiannya adalah suatu sistem tatanan yang menggambarkan bagaimana pandangan hidup masyarakatnya ditata dan tercermin dalam penggunaan ruang-ruang kotanya. Banyak hal bisa dibaca dari tatanan ruang sebuah kota, mulai dari kerjasama ataupun konflik dari berbagai kelompok yang mendiaminya, hubungan masyarakat warga dan elit-elitnya serta struktur ekonomi dari kehidupan kota dan faktor-faktor kehidupan yang mempengaruhi perkembangan kota tersebut. </em></p><em>Kajian ini akan melihat bagaimana konstelasi hubungan dan posisi bangunan-bangunan di dalam ruang Kota Surakarta, khususnya hubungan antara berbagai peristiwa dengan pembangunan eks bangunan RSJ Mangunjayan, Taman Sriwedari dan RS Kadipolo pada era pemerintahan Paku Buwono X. Metode yang digunakan adalah deskriptif, yaitu menjabarkan suatu keadaan melalui studi literature terhadap tulisan, fakta sejarah, foto dan peta yang berhubungan dengan pembangunan RSJ Mangunjayan dan menggambarkan kedudukan RSJ Mangunjayan di dalam struktur Kota Kolonial di Surakarta pada masa itu</em>.
KAJIAN PLACE ATTACHMENT DI KAMPUNG PECINAN TAMBAK BAYAN TENGAH, KOTA SURABAYA
Authors: Putra R Dimas Widya 
Published: July 2019

<em>Sungai Kalimas bersama dengan sungai Pegirikan merupakan dua struktur yang berperan penting dalam membentuk permukiman di Kota Surabaya. Di sepanjang tepian sungai Kalimas dan sungai Pegirikan ini terdapat permukiman-permukiman awal yang kini disebut sebagai kampung lama. kampung lama (permukiman awal) di kota Surabaya pada mulanya mengandalkan keberadaan sungai Kalimas dan sungai Pegirikan sebagai sumber kehidupan dan transportasi. Salah satu dari kampung lama tersebut adalah Tambak Bayan, Tambak Bayan merupakan kampung dengan etnis tionghoa yang masih bertahan di tengah perkembangan jaman. Kampung yang terbentuk setelah ratusan tahun ini masih bertahan dalam pesatnya pertumbuhan perekonomian pada Kota Surabaya. Di dalam kampung Tambak Bayan banyak masyarakat yang memiliki keterikatan emosi yang kuat terhadap kampung. Tujuan penelitian ini yaitu identifikasi nilai sosial-budaya, budaya bermukim masyarakat, dan keterkaitan antara struktur dan fungsi bagian wilayah Kota Surabaya. metode penelitian yang digunakan yaitu mengunakan analisis deskriptif – kualitatif yang diperoleh melalui index chart untuk mengetahui aspek keterkaitan warga kampung terhadap Tambak Bayan dan teknik analisis diachronic reading digunakan untuk menelusuri aspek perubahan kampung. Dari serangkaian hasil analisis menunjukkan bahwa keterikatan tempat dipengaruhi oleh faktor kekerabatan berupa akar keluarga dan kedekatan posisi kampung terhadap faktor tarikan, antara lain : pasar dan tempat bekerja.</em>
Compression therapy after posterior lumbar decompression and internal fixation: a prospective, randomized, clinical study
Authors: Sun Wu , Gao Jing-hua , Li-guo ZHU , Xiao Wei , Wang Zhen-zhong , Yang Ke-xin , Zhang Qing , Wang Bao-jian 
Published: July 2019

Abstract
Background: Wound-related complications have become an inevitable problem for spinal surgeons. Negative pressure drainage is the main method to prevent postoperative hematoma and related complications, which is still controversial. This prospective, randomized, controlled study was designed to evaluate the efficacy of compression therapy in the treatment of complications after posterior decompression and internal fixation of the lumbar spine, with emphasis on pain, anemia and inflammation.
Methods: Sixty consecutive patients with an average age of 59 years (43–78 years) who were selected for posterior lumbar decompression and internal fixation were randomly assigned into two groups with an equal number of patients. The groups comprised patients on closed suction drain with compression therapy after surgery or those with closed suction drain alone. The drainage volume, visual analogue scale pain score for back pain, white blood cell and red blood cell counts, hemoglobin levels, erythrocyte sedimentation rate, and C-reactive protein levels on the 1st, 3rd, and 10th days after the operation were compared between the two groups.
Results: The average follow-up was 6 months and ranged from 3 to 11 months. Drainage volume, the visual analogue scale score, and C-reactive protein levels on the 10th day after the operation were significantly lower in the treatment group than in the control group. The red blood cell count and hemoglobin levels on the 3rd and 10th days after the operation were significantly higher in the treatment group than in the control group (all P<0.05). At the time of discharge, wounds in the two groups showed grade A healing, and there were no signs of late infection in the groups.
Conclusions: For postoperative posterior lumbar decompression and internal fixation, compression therapy relieves pain, alleviates anemia and the inflammatory response.