bluuebunny/crossref_metadata_2025_split huggingface dataset:
Susac-Syndrom: ein diagnostisches Chamäleon
Authors: Stefanou M. I. , Doycheva D. , Ebrahimi A. , Dörr J.-M. , Ziemann U. 
Published: April 2019

AbstractSusac’s syndrome (SuS) is a rare, probably autoimmune endotheliopathy of the
central nervous system, retina and inner ear. It is characterized by a clinical
triad of encephalopathy, branch retinal artery occlusions (BRAOs) and
sensorineural hearing loss. To date, more than 300 cases of SuS have been
reported in the literature. However, SuS remains an under- and misdiagnosed
entity in the clinical setting. This report presents an exemplary case of a
patient, who was initially misdiagnosed with relapsing-remitting multiple
sclerosis. At initial presentation, the patient did not demonstrate the complete
clinical triad, and the interval between symptom onset and diagnosis was 4
months. Typical diagnostic features, which enabled the diagnosis of SuS were: a)
MRI findings with T2-hyperintense snowball-like lesions of the corpus callosum
and subcortical white matter and hyperintense lesions in diffusionweighted
imaging with reduced apparent diffusion coefficient; b) BRAOs and vessel wall
hyperfluorescence in fluorescein angiography and a significant thickness
reduction of the inner retinal layers in optical coherence tomography; c)
bilateral sensorineural hearing loss. The patient was aggressively treated with
cyclophosphamide, rituximab, glucocorticoids and acetylsalicylic acid with a
good response to therapy. This report draws attention to the need to take SuS
into consideration in the differential diagnosis at the interface of
neurological, psychiatric, ophthalmological and otorhinolaryngological
disorders. As SuS may result in severe and persistent neurological deficits, an
interdisciplinary collaboration is fundamental for the prompt diagnosis and
initiation of adequate immunosuppressive treatment.
Ästhetische Behandlungen mit Fillern und das Management von
Nebenwirkungen
Authors: Barsch M. , Buhren B. A. , Gerber P. A. 
Published: April 2019

ZusammenfassungMedizinisch-ästhetische Behandlungen sind für die tägliche dermatologische Praxis
von zunehmender Bedeutung. Als zentraler Bestandteil eines multimodalen
Therapiekonzeptes sind dermale und Volumenfiller aus der modernen ästhetischen
Therapie nicht mehr wegzudenken. Wegweisende Erkenntnisse zum Alterungsprozess
des Gesichtes und zur Sicherheit und Spezifika der verschiedenen Typen von
Füllstoffen der vergangenen Jahre bieten heute differenzierte
Anwendungsmöglichkeiten von Volumenaugmentation bis hin zu Hydratation oder
Kollageninduktion. Gleichsam sind aber auch der Markt an verfügbaren
Injektionsprodukten und die verschiedenen Indikationen und Injektionstechniken
nahezu unüberschaubar. Schließlich werden wir in der Praxis immer wieder mit
Komplikationen nach unsachgemäßer Anwendung oder den Langzeitkomplikationen von
in Deutschland längst nicht mehr verfügbaren Füllstoffen konfrontiert und auch
bei regelhafter Injektion sind Nebenwirkungen nicht ausgeschlossen. Die
vorliegende Arbeit soll einen Überblick über die am Markt verfügbaren aber auch
relevanten historischen bzw. obsoleten Filler und ferner über mögliche
Komplikationen und deren Management geben. Ferner finden sich persönliche
Bewertungen zu besonderen Indikationen bzw. Injektionstechniken.
Association between Cervical Spine Degeneration and the Presence of Dens Fractures
Authors: Betsch Marcel , Blizzard Sabina , Krishnamoorthy Bala , Yoo Jung 
Published: April 2019

Abstract
Purpose Results of a small case series indicate an increased risk of dens fractures in patients with osteoarthritis. The purpose of this retrospective cohort study was to analyze the relative risks associated with degeneration of the cervical spine in the occurrence of dens fractures in older patients.
Methods We performed a retrospective CT study of 1,794 patients > 55 years of age with and without dens fractures for signs of osteoarthritis (OA).
Results OA of the atlanto-dens interval (AdI) was present in 75.9% of fracture patients, whereas 63.5% of non-fracture patients had OA of the AdI (p = 0.04). In cases of osteoarthritis of the facet joints, we did find a significant increase (p < 0.05) in the dens fracture risk in patients with OA.
Conclusions This study indicates an association between OA of the cervical spine and the risk of sustaining a dens fracture. OA can lead to a reduction in the range of motion of the cervical spine. As a consequence, a relatively low-energy trauma can induce a forced sagittal motion, which will produce a torque at the base of the odontoid process resulting in a fracture.
Pharmacological treatment of hepatocellular carcinoma with cavoatrial tumor thrombus – case series and literature review
Authors: Zhan Tianzuo , Sollors Janina , Steinebrunner Niels , Schlitt Hans , Stroszczynski Christian , Weiss Karl , Ebert Matthias , Teufel Andreas 
Published: April 2019

AbstractHepatocellular carcinomas (HCC) that extend into the vena cava and the right atrium have a poor prognosis. Surgical approaches including partial hepatectomy and thrombectomy are the most frequently reported treatment options. However, most patients with advanced HCC are not eligible for complex surgical interventions due to reduced liver function, comorbidities, and metastases. At the same time, systemic treatment options of HCC have expanded in recent years. Here, we report 3 cases of patients with advanced HCC who developed a cavoatrial tumor thrombus (CATT) after initial surgical or interventional therapy. The patients were consequently treated with sorafenib or nivolumab. In all cases, the tumor responded to systemic treatment with disease stabilization or partial regression. Overall survival after diagnosis of CATT was 3 and 17 months for sorafenib and 7 + months for nivolumab. Compared to survival rates of alternative treatment options, systemic therapies demonstrated comparable outcomes. In summary, pharmacotherapy is an efficient and well worth option to treat patients with HCC and CATT and should be an integral part of a multimodal therapy concept.
Practical Aspects and Avoidance of Complications in Microendoscopic Spine Surgeries: A Review
Authors: Yadav Yad Ram , Lucano Angelo , Ratre Shailendra , Parihar Vijay Singh 
Published: April 2019

Introduction Although the indications for endoscopic procedures have increased in recent times, there are also some limitations. This review discusses the practical points to prevent and treat complications in microendoscopic spine surgery.
Material and Methods A literature search was conducted for the relevant articles after a topic search on PubMed, Google Scholar, and Medline. The review is based on the experience of 1,574 spinal endoscopic procedures performed by the senior author.
Results Advantages of endoscopic surgery include better visualization, panoramic vision, and the ability to work around corners. Limitations with endoscopic procedures include proximal blind areas, obstruction in instrument handling due to a narrow corridor, disorientation, frequent lens fogging, loss of depth perception, and difficulty in achieving hemostasis, leading to complications and longer operative time during the learning curve.
Conclusion Surgeons need to learn endoscopic skills in addition to microsurgical ones to perform microendoscopic procedures properly. Attending live workshops, watching operative videos, visiting various departments, watching an experienced and accomplished endoscopic surgeon, proper case selection, a multidisciplinary team approach, practicing on models, hands-on cadaveric workshops, laboratory training, and simulators can improve results and shorten the learning curve.
Successful Management of Pulmonary Arterial Hypertension by Monitoring N-Terminal Pro-B-Type Natriuretic Peptide Serum Levels in a Preterm Infant with Chronic Lung Disease: A Case Report
Authors: Seki Keigo , Iwashima Satoru , Uchiyama Hiroki , Ohishi Akira , Ishikawa Takamichi 
Published: April 2019

AbstractWe measured the serial changes in N-terminal probrain natriuretic peptide (NT-proBNP) levels in a 6-month-old male infant with chronic lung disease (CLD) complicated by pulmonary arterial hypertension (PAH). The patient was born at the 24th week of gestation weighing 695 g. At 1 month after birth, an echocardiogram confirmed the diagnosis of CLD with PAH. He was treated with inhaled nitric oxide (iNO) and oral sildenafil and discharged from the hospital. At 190 days of age, the patient was readmitted to our department because of a viral upper respiratory infection. At 195 days of age, his respiratory condition worsened with pulmonary edema and his NT-proBNP level was determined to be 10,117 pg/mL. The patient was immediately administered iNO, and his respiratory condition improved, and NT-proBNP levels decreased. However, he experienced repeated severe cyanosis attacks. Before the attacks, his NT-proBNP level was > 1,000 pg/mL. Therefore, we continuously administered iNO until his NT-proBNP level decreased to < 1,000 pg/mL. We safely discontinued iNO administration at 473 days of age. In conclusion, serial change in NT-proBNP is a surrogate marker with prognostic value in patients with PAH associated with CLD.
Intervenciones no farmacológicas para la disminución del dolor en cistoscopia
Authors: Guzman-Mejia Natalia , García-Perdomo Herney Andrés 
Published: April 2019

ResumenObjetivo Generar una aproximación a las terapias no farmacológicas que disminuyan el dolor durante la realización de la cistoscopia.Métodos Se realizó una búsqueda de la literatura para identificar artículos relevantes con respecto al tópico, utilizando como palabras clave: cistoscopia, dolor, terapia no farmacológica en cistoscopia y terapias alternativas. La búsqueda se hizo a través de Medline y Embase. Se realizó una revisión narrativa.Resultados Aunque la cistoscopia flexible aumenta la tolerancia, especialmente en pacientes masculinos, el dolor sigue siendo inevitable durante la misma. Se han estudiado diferentes intervenciones no farmacológicas orientadas a disminuir el dolor y la ansiedad durante la cistoscopia, entre las que se encuentran: escuchar música, tomar la mano del paciente, ver el procedimiento en tiempo real, el aumento de la presión hidrostática, insuflación con aire y la hipnosis.Conclusión Esas intervenciones podrían ser usadas como adyuvantes en la disminución del dolor y la ansiedad durante la cistoscopia, principalmente la masculina. Sin embargo, se requieren más estudios que comprueben su uso clínico apropiado.
Is There a Supporting Value of Platelet Distribution Width and Plateletcrit in the Diagnosis of Acute Appendicitis in Children?
Authors: Bilici Salim , Öztaş Tülin , Dursun Ahmet 
Published: April 2019

AbstractThis study was designed to investigate the diagnostic value of platelet distribution width (PDW) and plateletcrit (PCT) for acute appendicitis in childhood. A retrospective review was conducted of the records of 373 patients younger than 18 years who underwent appendectomy. Demographic data, white blood cell count, neutrophil count, and PDW and PCT values were recorded for all patients. A control group was formed of age- and gender-matched healthy children. The study results showed that the PDW level is not valuable as a marker for the diagnosis of acute appendicitis in children. PCT levels were determined to be statistically significantly increased in pediatric acute appendicitis with low specificity.
Indium doping effect on properties of ZnO nanoparticles synthesized by sol–gel method*
Authors: Mourad S , El Ghoul J , Omri K , Khirouni K 
Published: April 2019

Abstract
Pure ZnO and indium-doped ZnO (In–ZO) nanoparticles with concentrations of In ranging from 0 to 5% are synthesized by a sol–gel processing technique. The structural and optical properties of ZnO and In–ZO nanoparticles are characterized by different techniques. The structural study confirms the presence of hexagonal wurtzite phase and indicates the incorporation of In3+ ions at the Zn2+ sites. However, the optical study shows a high absorption in the UV range and an important reflectance in the visible range. The optical band gap of In–ZnO sample varies between 3.16 eV and 3.22 eV. The photoluminescence (PL) analysis reveals that two emission peaks appear: one is located at 381 nm corresponding to the near-band-edge (NBE) and the other is observed in the green region. The aim of this work is to study the effect of indium doping on the structural, morphological, and optical properties of ZnO nanoparticles.
The productivity of kacang goat pre-weaning period in low-land and high-land in West Timor, Timor Island Indonesia
Authors: Nasich M , Sarah O L , Ciptadi G , Busono W , Budiarto A 
Published: April 2019

Abstract
This experiment aimed to determine and analyze the productivity of pre-weaning Kacang goats in the lowlands and highlands area of West Timor province, Indonesia. The results of this study were expected to be used as a reference for maintaining Kacang goats in Indonesia. This research was conducted in West Timor province, Timor Island. The material used in this study was 245 Kacang goats consisting of 96 does, and 149 kids. The research method used was the survey. The result showed that the average of litter size to Kacang goats in the lowlands were 1.6 + 0.63 heads and highlands 1.5 + 0.55. The average male birth weight in the lowlands was 1.7 + 0.32 kg, females 1.55 + 0.22 kg, while in the highlands, males were 1.62 + 0.15 kg, females 1.47 + 0.18 kg. The average weaning weight of males was 9.21 + 0.59 kg, females 8.65 + 0.65 kg in the lowlands and in the highlands, males 8.62 + 0.46 kg and females 8.27 + 0, 38 kg. From the results, it can be concluded that Kacang goats were considered more suitable to be maintained in the lowlands, however, even in the highlands it is also still considered good.
Reproduction characteristics of Simeulue Buffalo in Alafan district in Simeulue Island
Authors: Sari Eka Meutia , Mizan Khairul , Nashri Abdullah Mohd Agus 
Published: April 2019

Abstract
The purpose of this study was to identify the female buffalo reproductive characteristics in Alafan district of Simeulue Regency in Simeulue Island. This research used survey method in four villages within Alafan district, namely: Lafakha, Lubuk Baik, Lewak, and Langi. Fourty respondents of buffalo breeders we selected based on purposive sampling method, with the minimum requirement of breeder keep two productive buffalos which have been given birth twice and breeder have experience more than one year. Data collection done by interview and was discussion techniques. The parameters observed were: (a) conception period; (b) the age of buffalo have the first child; (c) calving intervals; and (d) service period. The data obtained processed and calculated averaged and then descended and described descriptively. The results showed that the female buffalo reproductive characteristics in Alafan district of Simelue Regency in Simeulue Island was good enough. The conception period was 10.46 months, the age of buffalo have the first child at 3.8 years (45.6 months), calving interval was 17.3 months, and service period was 7.5 months.
Integrated farming system of duck and rice in the coast of Tondano Lake in the Regency of Minahasa
Authors: Elly FH , Polakitan D , Salendu AHS , Pomolango R , Wantasen E 
Published: April 2019

Abstract
Farmers on the coast of Lake Tondano, mostly cultivate rice crops. In addition, duck farming also developed by farmers as the source of their income. Development of duck with rice was done with an integrated farming system. The problem was, whether integrated farming system of ducks and rice can provide benefits to farmers. This research was conducted with the aim of analyzing the benefits of the integration of duck and rice farming. Determination of research locations in Minahasa Regency was carried out by purposive sampling. This determination was carried out with the consideration that the sample location was the center of development of integrated duck rice farming. Data analysis used was RC ratio and analysis of investment criteria (BC ratio, NPV dan IRR). Farmers’ income from the development of integrated duck rice farming was more than non integration. The results of the research show that the revenue of integrated of rice duck farming per year was Rp. 75,546,633 with the costs of Rp. 49,013,896. The RC value of the ratio was 1.54 which shows that integrated farming provides benefits for farmers. The results of the investment criteria analysis show that the integration of duck rice farming provides benefits to farmers. This was shown from the BC ratio which has a greater value one, the NPV was positive and the IRR was greater than the bank interest rate that applies in the study area. Based on the results of the study it can be concluded that the integration of duck and rice farming provides greater benefits for farmers. Suggestions that need to be submitted were suggestions for the government to socialize the development of ducks integrated with rice.
Distracted decision makers: ship noise and predation risk change shell choice in hermit crabs
Authors: Tidau Svenja , Briffa Mark 
Published: April 2019

Abstract
Human-induced rapid environmental change such as noise pollution alters the ability of animals to integrate information cues. Many studies focus on how noise impacts single sensory channels but in reality animals rely on multimodal sources of information. In this study, we investigated the effect of anthropogenic noise and the visual presence of a predator on tactile information gathering during gastropod shell assessment in the European hermit crab Pagurus bernhardus. For hermit crabs, empty gastropod shells are a crucial resource affecting growth, reproduction, and survival. We measured shell assessment behavior and manipulated 1) the shell size (50% or 80% of the optimal), 2) sound condition (ship or ambient), and 3) visual predator cue (absence/presence). Overall we found that crabs were less likely to accept an optimal shell in the presence of ship noise, suggesting that exposure to ship noise disrupted the information gathering ability of the crabs. We also found a significant interaction between noise, predator presence, and shell size on the mean duration for the final decision to accept or reject the optimal shell. Hermit crabs in 50% shells took less time for their final decision when exposed to both ship noise and predator cue while crabs in 80% shells showed shorter decision time only when the predator cue was absent. Our results indicate that anthropogenic noise can interact with predation threat and resource quality to change resource acquisition, suggesting that noise pollution can disrupt behavior in a nonadditive way, by disrupting information use across multiple sensory channels.
Identifying centromeric satellites with dna-brnn
Authors: Li Heng 
Published: April 2019

Abstract

Summary
Human alpha satellite and satellite 2/3 contribute to several percent of the human genome. However, identifying these sequences with traditional algorithms is computationally intensive. Here we develop dna-brnn, a recurrent neural network to learn the sequences of the two classes of centromeric repeats. It achieves high similarity to RepeatMasker and is times faster. Dna-brnn explores a novel application of deep learning and may accelerate the study of the evolution of the two repeat classes.

Availability and implementation
https://github.com/lh3/dna-nn
Shifts of Spatial Attention in Visual and Tactile Working Memory are Controlled by Independent Modality-Specific Mechanisms
Authors: Katus Tobias , Eimer Martin 
Published: April 2019

Abstract
The question whether the attentional control of working memory (WM) is shared across sensory modalities remains controversial. Here, we investigated whether attention shifts in visual and tactile WM are regulated independently. Participants memorized visual and tactile targets in a first memory sample set (S1) before encoding targets in a second sample set (S2). Importantly, visual or tactile S2 targets could appear on the same side as the corresponding S1 targets, or on opposite sides, thus, requiring shifts of spatial attention in visual or tactile WM. The activation of WM representations in modality-specific visual and somatosensory areas was tracked by recording visual and tactile contralateral delay activity (CDA/tCDA). CDA/tCDA components emerged contralateral to the side of visual or tactile S1 targets, and reversed polarity when S2 targets in the same modality appeared on the opposite side. Critically, the visual CDA was unaffected by the presence versus absence of concurrent attention shifts in tactile WM, and the tactile CDA remained insensitive to visual attention shifts. Visual and tactile WM performance was also not modulated by attention shifts in the other modality. These results show that the dynamic control of visual and tactile WM activation processes operates in an independent modality-specific fashion.
Rates of New Human Immunodeficiency Virus (HIV) Diagnoses After Reported Sexually Transmitted Infection in Women in Louisiana, 2000–2015: Implications for HIV Prevention
Authors: Newman Daniel R , Rahman Mohammad M , Brantley Antoine , Peterman Thomas A 
Published: April 2019

Abstract

Background
Human immunodeficiency virus (HIV) prevention interventions for prevention interventions for women include screening, partner notification, promoting condoms, and preexposure prophylaxis (PrEP). Women’s risk of acquiring HIV can help guide recommendations.

Methods
We used data from Louisiana’s sexually transmitted infection (STI) and HIV registries to study 13- to 59-year-old women following first diagnosis of syphilis, gonorrhea, or chlamydia during 2000–2015. We measured HIV rates reported subsequent to STI (through 2016). Rates for women without STI were estimated by subtracting women with STI from reported cases and from Census estimates for the population. PrEP cost was estimated as $11 000 per year, and effectiveness estimated as 100%.

Results
STIs were syphilis (6574), gonorrhea (64 995), or chlamydia (140 034). These 211 603 women had 1 865 488 person-years of follow-up and 969 HIV diagnoses. Women with no STI had 5186 HIV diagnoses over 24 359 397 person-years. HIV rates diagnosis (per 100 000 person-years) were higher for women after syphilis (177.3), gonorrhea (73.2), or chlamydia (35.4) compared to women with no STI (22.4). Providing PrEP to all women diagnosed with syphilis or gonorrhea would cost $7 371 111 000 and could have prevented 546 HIV diagnoses. Limiting PrEP to 1 year after syphilis or gonorrhea diagnosis would cost $963 847 334, but only 143 HIV diagnoses were within 2 years after a syphilis or gonorrhea diagnosis.

Conclusions
Rates of HIV diagnosis were high after women had STI, but not high enough to make PrEP cost-effective for them. Most women diagnosed with HIV did not have previously reported STI.
Total root remodelling by the Sleeve technique for aortic regurgitation in patients with repaired tetralogy of Fallot
Authors: Eishi Junichiro , Miura Takashi , Obase Kikuko , Eishi Kiyoyuki 
Published: April 2019

Abstract
We report the case of a 15-year-old male patient who had developed aortic regurgitation primarily because of aortic annulus dilatation late after definitive repair of tetralogy of Fallot. Valsalva sinus dilatation was not remarkable enough for root replacement. For the purpose of total root remodelling, the Sleeve procedure was employed. This procedure not only reduced the root diameters but also augmented commissure heights. With concomitant non-coronary cusp plication, aortic regurgitation was effectively controlled. Thus, the Sleeve technique may be a preferable option for patients who develop aortic regurgitation, due to dilatation of the annulus or sinotubular junction without significant dilatation of the sinus of Valsalva, after congenital heart surgery.