bluuebunny/crossref_metadata_2025_split huggingface dataset:
Adapting the ELEAT (Early Life Exposure Assessment Tool) to Portugal – a pilot study to tackle gene-environment interactions in Autism Spectrum Disorder
Authors: Rasga Celia , Santos João Xavier , Lopes Ana Leonie , Marques Ana Rita , Vilela Joana , Asif Muhammad , Oliveira Guiomar , Bennett Deborah , Walker Cheryl , Schmidt Rebecca J. , Vicente Astrid Moura 
Published: January 2019

ABSTRACTBackgroundAutism Spectrum Disorder (ASD) is a pervasive and clinically heterogeneous neurodevelopmental disorder characterized by deficits in social communication and interaction skills, and repetitive and stereotyped behaviours. It is known that ASD has a strong genetics component, but heritability estimates of 50-80% suggest that modifiable non-genetic factors may play an important role in the onset of the disorder. Recently, pre-, peri and post-natal exposure to a variety of environmental factors has been implicated in ASD. Yet, the comprehensive assessment of environmental exposures in this pathology, using large population datasets, is still lacking. The objective of this study was to pilot an environmental exposure assessment tool in Portugal.MethodsTo examine environmental exposures in a population of Portuguese children with ASD, we translated, adapted and piloted the Early Life Exposure Assessment Tool (ELEAT). The ELEAT was originally developed to assess environmental factors in studies of neurodevelopmental disorders. It is a questionnaire filled by mothers of children with ASD, enquiring about Demographic Information, Maternal Conditions/Medical Interventions, Breastfeeding and Child Diet, Maternal Diet, Supplements, Lifestyle, Home and Environment, Environment, Occupation and Exposures. The ELEAT gathers information about environmental exposure along key phases for early neurodevelopment, from 3 months prior to conception, pregnancy, labor and delivery to the first year of life of the child. Two focus groups were realized, one with mothers of typically-developing children and another with mothers of children with ASD, in order to discuss the mothers opinion regarding the tool comprehensiveness and relevance.ResultsThe large majority of mothers were sure about their answers for all modules, with a small fraction of the group reporting difficulties for the Occupations/Exposures module. Most mothers considered the ELEAT to be a little too long, but generally found that the instructions were clear and, most importantly, agreed that the questions were important.ConclusionsIntegration of the pilot feedback will allow us to enhance the tool and optimize its usage in Portuguese-speaking communities, improving its capacity to assemble accurate environmental data from diverse cultural settings, and to be extended to larger population datasets. Combined with genetic and clinical data, the ELEAT will contribute to the identification of modifiable lifestyle and environmental risk factors for ASD. Such evidence may eventually provide the opportunity for disease prevention or reduced severity by mitigating exposure when genetic susceptibility is identified early in life.
A new transgenic reporter line reveals Wnt-dependent Snail2 reexpression and cranial neural crest differentiation in Xenopus
Authors: Li Jiejing , Perfetto Mark , Materna Christopher , Li Rebecca , Tran Hong Thi , Vleminckx Kris , Duncan Melinda K. , Wei Shuo 
Published: January 2019

AbstractDuring vertebrate embryogenesis, the cranial neural crest (CNC) forms at the neural plate border and subsequently migrates and differentiates into many types of cells. The transcription factor Snail2, which is induced by canonical Wnt signaling to be expressed in the early CNC, is pivotal for CNC induction and migration in Xenopus. However, snail2 expression is silenced during CNC migration, and its roles at later developmental stages remain unclear. We generated a transgenic X. tropicalis line that expresses enhanced green fluorescent protein (eGFP) driven by the snail2 promoter/enhancer, and observed eGFP expression not only in the pre-migratory and migrating CNC, but also the differentiating CNC. This transgenic line can be used directly to detect deficiencies in CNC development at various stages, including subtle perturbation of CNC differentiation. In situ hybridization and immunohistochemistry confirm that Snail2 is reexpressed in the differentiating CNC. Using a separate transgenic Wnt reporter line, we show that canonical Wnt signaling is also active in the differentiating CNC. Blocking Wnt signaling shortly after CNC migration causes reduced snail2 expression and impaired differentiation of CNC-derived head cartilage structures. These results suggest that Wnt signaling drives the reexpression of snail2 in the post-migratory CNC and regulates CNC differentiation.
Spatial summation of individual cones in human color vision
Authors: Schmidt Brian P. , Boehm Alexandra E. , Tuten William S. , Roorda Austin 
Published: January 2019

AbstractThe human retina contains three classes of cone photoreceptors each sensitive to different portions of the visual spectrum: long (L), medium (M) and short (S) wavelengths. Color information is computed by downstream neurons that compare relative activity across the three cone types. How cone signals are combined at a cellular scale has been more difficult to resolve. This is especially true near the fovea, where spectrally-opponent neurons in the parvocellular pathway draw excitatory input from a single cone and thus even the smallest stimulus will engage multiple color-signaling neurons. We used an adaptive optics microstimulator to target individual and pairs of cones with light. Consistent with prior work, we found that color percepts elicited from individual cones were predicted by their spectral sensitivity, although there was considerable variability even between cones within the same spectral class. The appearance of spots targeted at two cones were predicted by an average of their individual activations. However, two cones of the same subclass elicited percepts that were systematically more saturated than predicted by an average. Together, these observations suggest both spectral opponency and prior experience influence the appearance of small spots.
Computational design of improved standardized chemotherapy protocols for grade II oligodendrogliomas
Authors: Pérez-García Víctor M. , Ayala-Hernández Luis E. , Belmonte-Beitia Juan , Schucht Philippe , Murek Michael , Raabe Andreas , Sepúlveda Juan 
Published: January 2019

AbstractThe use of mathematical models for personalization of cancer therapies and raising hypothesis of potential clinical impact is an emerging topic in the interface between mathematics and oncology. Here we put forward a mathematical model describing the response of low-grade (WHO grade II) oligodendrogliomas (LGO) to temozolomide (TMZ). The model described the longitudinal volumetric dynamics of tumor response to TMZ of a cohort of 11 LGO patients treated with TMZ. After finding patient-specific parameters, different therapeutical strategies were tried computationally on the ‘in-silico twins’ of those patients. Chemotherapy schedules with larger-than-standard rest periods between consecutive cycles had either the same or better long-term efficacy than the standard 28-day cycles. The results were confirmed in a large virtual clinical trial including 2000 patients. These long-cycle schemes would also have reduced toxicity and defer the appearance of resistances.On the basis of those results, a combination scheme consisting of five induction TMZ cycles given monthly plus 12 maintenance cycles given every three months was found to provide substantial survival benefits for the in-silico twins of the 11 LGO patients (median 5.69 years, range: 0.67 to 68.45 years) and in a large virtual trial including 2000 patients. This scheme could be useful for defining a standardized TMZ treatment for LGO patients with survival benefits.Author summaryA mathematical model described the longitudinal volumetric growth data of grade II oligodendrogliomas patients and their response to temozolomide. The model was used to explore alternative therapeutical protocols for the in-silico twins of the patients and in virtual clinical trials. The simulations show that enlarging the time interval between chemotherapy cycles would maintain the therapeutical efficacy, while limiting toxicity and defering the development of resistances. This may allow for improved drug-exposure by administering a larger number of cycles for longer treatment periods. A scheme based on this idea consisting of an induction phase (5 consecutive cycles, 1 per month) and a maintenance phase (12 cycles given in three-months intervals) led to substantial survival benefits in-silico.
The emergence of integrated information, complexity, and consciousness at criticality
Authors: Khajehabdollahi Sina , Abeyasinghe Pubuditha M. , Owen Adrian M. , Soddu Andrea 
Published: January 2019

AbstractUsing the critical Ising model of the brain, integrated information as a measure of consciousness is measured in toy models of generic neural networks. Monte Carlo simulations are run on 159 random weighted networks analogous to small 5-node neural network motifs. The integrated information generated by this sample of small Ising models is measured across the model parameter space. It is observed that integrated information, as a type of order parameter not unlike a concept like magnetism, undergoes a phase transition at the critical point in the model. This critical point is demarcated by the peaks of the generalized susceptibility of integrated information, a point where the ‘consciousness’ of the system is maximally susceptible to perturbations and on the boundary between an ordered and disordered form. This study adds further evidence to support that the emergence of consciousness coincides with the more universal patterns of self-organized criticality, evolution, the emergence of complexity, and the integration of complex systems.Author summaryUnderstanding consciousness through a scientific and mathematical language is slowly coming into reach and so testing and grounding these emerging ideas onto empirical observations and known systems is a first step to properly framing this ancient problem. This paper in particular explores the Integrated Information Theory of Consciousness framed within the physics of the Ising model to understand how and when consciousness, or integrated information, can arise in simple dynamical systems. The emergence of consciousness is treated like the emergence of other classical macroscopic observables in physics such as magnetism and understood as a dynamical phase of matter. Our findings show that the sensitivity of consciousness in a complex system is maximized when the system is undergoing a phase transition, also known as a critical point. This result, combined with a body of evidence highlighting the privelaged state of critical systems suggests that, like many other complex phenomenon, consciousness may simply follow from/emerge out of the tendency of a system to self-organize to criticality.
What counts for quality in interdisciplinary accounting research in the next decade
Authors: Guthrie James , Parker Lee D. , Dumay John , Milne Markus J. 
Published: January 2019

Purpose
The purpose of this paper is to reflect upon the focus and changing nature of measuring academic accounting research quality. The paper addresses contemporary changes in academic publishing, metrics for determining research quality and the possible impacts on accounting scholars. These are considered in relation to the core values of interdisciplinary accounting research ‒ that is, the pursuit of novel, rigorous, significant and authentic research motivated by a passion for scholarship, curiosity and solving wicked problems. The impact of changing journal rankings and research citation metrics on the traditional and highly valued role of the accounting academic is further considered. In this setting, the paper also provides a summary of the journal’s activities for 2018, and in the future.

Design/methodology/approach
Drawing on contemporary data sets, the paper illustrates the increasingly diverse and confusing array of “evidence” brought to bear on the question of the relative quality of accounting research. Commercial products used to rate and rank journals, and judge the academic impact of individual scholars and their papers not only offer insight and visibility, but also have the potential to misinform scholars and their assessors.

Findings
In the move from simple journal ranking lists to big data and citations, and increasingly to concerns with impact and engagement, the authors identify several challenges facing academics and administrators alike. The individual academic and his or her contribution to scholarship are increasingly marginalised in the name of discipline, faculty and institutional performance. A growing university performance management culture within, for example, the UK and Australasia, has reached a stage in the past decade where publication and citation metrics are driving allocations of travel grants, research grants, promotions and appointments. With an expanded range of available metrics and products to judge their worth, or have it judged for them, scholars need to be increasingly informed of the nuanced or not-so-nuanced uses to which these measurement systems will be put. Narrow, restricted and opaque peer-based sources such as journal ranking lists are now being challenged by more transparent citation-based sources.

Practical implications
The issues addressed in this commentary offer a critical understanding of contemporary metrics and measurement in determining the quality of interdisciplinary accounting research. Scholars are urged to reflect upon the challenges they face in a rapidly moving context. Individuals are increasingly under pressure to seek out preferred publication outlets, developing and curating a personal citation profile. Yet such extrinsic outcomes may come at the cost of the core values that motivate the interdisciplinary scholar and research.

Originality/value
This paper provides a forward-looking focus on the critical role of academics in interdisciplinary accounting research.
To speak or not to speak the language of numbers: accounting as ventriloquism
Authors: Fauré Bertrand , Cooren François , Matte Frédérik 
Published: January 2019

Purpose
The purpose of this paper is to extend the literature on accounting’s performativity by developing a ventriloquial perspective that directs the attention to the reciprocity between the accounting signs and the accountants: they both do things by making each other speak. This oscillation explains where accounting number’s authority, materiality and resistance come from.

Design/methodology/approach
In order to show the relevance of this approach, the authors examine various ways numbers manage to speak or do things in the context of video-recorded conversations taken from fieldwork completed with Médecins sans frontières (also known as Doctors without Borders) in the Democratic Republic of the Congo.

Findings
The analyses show how this ventriloquial perspective can inform the way the authors interpret what happens: when numbers do not say the same thing; when numbers are competing with other figures; and when numbers backfire on their own promoters.

Research limitations/implications
Even if some of the numbers studied are sometimes far from accounting per se, it shows how the absence or presence of accounting can make a difference.

Practical implications
The authors then discuss the implications of this research for accounting social innovation through accounting inscriptions.

Social implications
This perspective helps to understand that numbers can give great power, but that everything cannot be told with numbers. This is why making numbers speak is a great talent.

Originality/value
This refreshing perspective on accounting could be extended to other fields such as auditing and auditing.
A resource-based perspective on work–family conflict: meta-analytical findings
Authors: Liao Eko Yi , Lau Victor P. , Hui Ray Tak-yin , Kong Kaylee Hao 
Published: January 2019

PurposeThe purpose of this paper is to provide an updated and theory-driven meta-analysis of work–family conflict (WFC). The authors quantitatively review the relationships between WFC and three pairs of antecedents and several consequences.Design/methodology/approachA meta-analysis was conducted to investigate the research model. Specifically, the authors adopt a resource-based perspective (i.e. conservation of resources (COR) theory) to investigate the relationships between three pairs of antecedents (demand/control, autonomy/hours spent at both work and family domains and role overload/flexibility) and WFC. While COR theory argues that resource loss perceptions would generate much more influential impact on individuals comparing to that of resource gain, both favourable and unfavourable antecedents, representing resource gain and resource loss, respectively, are incorporated in each pair of antecedents. This inclusion of contrary antecedents allows the authors to investigate the comparison of the relationships between the favourable antecedents – WFC relationships and the unfavourable factors – WFC relationships. In addition, the authors analyse how and to what extent WFC influences employees’ attitudes (i.e. commitment), behaviours (i.e. performance) towards both work and family, and their career consequences.FindingsThe meta-analytical findings generally support the hypotheses. Work and family demands are found positively related to WFC, while having a control at either work or family would be negatively related to WFC. Perceiving a high level of autonomy at work is negatively related to WFC, and hours spend at work has a positive relation with WFC. Role overload at both work and family are associated with WFC, while having flexibility from work schedule would be negatively related to WFC. In addition, WFC is negatively related to employee career development outcomes.Originality/valueFirst, the authors adopt a resource-based view to organise both favourable and unfavourable antecedents of WFC. Second, this paper aims at extending the investigation on WFC consequences to performance at both work and family, commitment to both work and family, and employee career outcomes, because all of them are critical consequences but not fully explored in previous meta-analyses. Third, this paper has incorporated newly explored correlates of WFC (e.g. employee career development-related outcomes) and quantitatively reviewed their relationships with WFC.
A panel for lemons? Positivity bias, reputation systems and data quality on MTurk
Authors: Matherly Ted 
Published: January 2019

PurposeThe purpose of this paper is to investigate how the effectiveness of systems for ensuring cooperation in online transactions is impacted by a positivity bias in the evaluation of the work that is produced. The presence of this bias can reduce the informativeness of the reputation system and negatively impact its ability to ensure quality.Design/methodology/approachThis research combines survey and experimental methods, collecting data from 1,875 Mechanical Turk (MTurk) workers in five studies designed to investigate the informativeness of the MTurk reputation system.FindingsThe findings demonstrate the presence of a positivity bias in evaluations of workers on MTurk, which leaves them undifferentiated, except at the extremity of the reputation system and by status markers.Research limitations/implicationsBecause MTurk workers self-select tasks, the findings are limited in that they may only be generalizable to those who are interested in research-related work. Further, the tasks used in this research are largely subjective in nature, which may decrease their sensitivity to differences in quality.Practical implicationsFor researchers, the results suggest that requiring 99 per cent approval rates (rather than the previously advised 95 per cent) should be used to identify high-quality workers on MTurk.Originality/valueThe research provides insights into the design and use of reputation systems and demonstrates how design decisions can exacerbate the effect of naturally occurring biases in evaluations to reduce the utility of these systems.
Using Facebook for travel decision-making: an international study of antecedents
Authors: Mariani Marcello , Ek Styven Maria , Ayeh Julian K. 
Published: January 2019

Purpose
This paper aims to investigate antecedents of using non-travel-specific social media (specifically Facebook) for travel decision-making before a leisure trip.

Design/methodology/approach
Based on an online survey of 426 young travel consumers from Italy and Sweden, this work applies structural equation modeling and multi-group analysis.

Findings
The study finds support for most of the conventional TAM-related constructs: perceived usefulness, perceived enjoyment and intention, while ease of use is not found relevant in this context.

Research limitations/implications
Results shed light on the antecedents of using non-travel specific social media in two countries. Future research might focus on validating the factors identified and add others that might shape usage in the selected countries. Future studies could further investigate possible differences arising from culture, country of origin and age. The analysis can also be extended to other countries.

Practical implications
The analysis might help managers in the hospitality and tourism sector by providing an understanding of the cognitive factors which determine travelers’ decision to use Facebook for trip planning. Thus, managers should get to know these factors in their effort to influence social media in hospitality and tourism settings.

Originality/value
The findings offer interesting perspectives on the applicability of conventional models to the context of non-travel-specific social media platforms. The exploration of cross-cultural differences also adds to the extant body of knowledge.
The concept of Datenherrschaft of patient information from a Heideggerian perspective
Authors: Koskinen Jani Simo Sakari 
Published: January 2019

PurposeIn this paper, patient information is approached from a Heideggerian perspective with the intention to gather an understanding about the personal nature of the information. The purpose of this paper is to analyse the ownership of patient information and then present Datenherrschaft (German for “mastery over information”) as a suitable model for patient ownership of patient information.Design/methodology/approachThis paper is theoretical in approach. It is based on arguments derived from Heidegger’s work in the Being and Time.FindingsBased on this Heideggerian approcah, a proposal for using the special definition of ownership of patient information – Datenherrschaft – given to a patient is suggested. From a Heideggerian perspective, it can be stated that the patient has the strongest rights towards patient information because this information is crucial for a patient to have an understanding about their Dasein (being-in-the-world).Research limitations/implicationsDatenherrschaft is used as an example of an ethically justified way of regulating the patient information ownership and should be analysed further. Especially the practical implications of implementing Datenherrschaft need more research.Originality/valuePatient information ownership is an issue that is neither unambiguously solved in many countries, nor has it, in our view, been ethically justified. The potential solution – Datenherrschaft – presented in this paper is clear and has strong philosophical justifications.