bluuebunny/crossref_metadata_2025_split huggingface dataset:
Neuroprotective Role of Ranolazine: ESR1 and NMDA Receptor Agonist in Traumatic Brain Injury in Drosophila melanogaster, In Silico and In Vivo Correlation
Authors: Parvesh Parvesh , Kumar Sandeep , Singh Govind , Khatri Ramchander , Sharma Sarita , Lather Amit , Hooda Tanuj 
Published: November 2024

Abstract
Objective In this study, a high-impact trauma (HIT) device was used for inducing moderate traumatic brain injury (TBI) in Drosophila melanogaster. Mechanical injuries in flies caused by rapid acceleration and assertion produce symptoms characteristics of TBI in humans.
Materials and Methods Docking studies were carried out to check the binding affinity of the drug toward the receptors. Various oxidative stress parameters, catalase level, glutathione level, superoxide dismutase (SOD) level, malondialdehyde (MDA), and nitric oxide levels, were measured. The mortality index and neuroprotective potential were carried out in TBI in D. melanogaster models.
Results In the current study, there was an increase in oxidative stress following TBI as evidenced by a significant decrease in the catalase, glutathione, and SOD levels and increase in the level of MDA and nitric oxide after 24 hours. Antioxidant enzymes, catalase and glutathione peroxidase, have a dominant role in TBI. Docking studies were carried out on estrogen receptor 1 (pdb: 1TVO and 1UOM) and NDMA receptor (pdb: 3QEL) as agonist showing the binding affinity of the drug toward the receptors. In comparison to the vehicle-treated group, there was a dose-dependent significant increase in the SOD level and percentage climbing along with a decrease in the MDA level and total protein content. The mortality index was also observed at three concentrations of ranolazine (1, 2, and 4 mg/mL) in D. melanogaster homogenate. These findings suggest that ranolazine has a good neuroprotective potential in the treatment of TBI in the D. melanogaster model.
Conclusion Present study concluded the scientific evaluation of neuroprotective potential of ranolazine in the treatment of TBI in the D. melanogaster model.
Prognostic Factors of Recovery and Discharge Outcome in Adults after Moderate Traumatic Brain Injury
Authors: Elnoamany Hossam , Sisi Yasser Bahgat El , Elsoud Abdulla Mostafa Abdulla Abu , Omar Ayman Ahmed , Elkholy Hany 
Published: November 2024

Abstract
Background Traumatic brain injury (TBI) is a leading cause of mortality and morbidity particularly among young people. Identification of prognostic factors can be considerably helpful for clinical decision-making and prediction of outcome.
Objective The aim of this study was to identify prognostic factors supposed to be of value in predicting functional outcome in moderate TBI patients.
Materials and Methods This was a prospective case series study conducted from March 2023 to January 2024 involving 72 TBI patients with a Glasgow Coma Scale (GCS) score of 9 to 13. Demographic, clinical, laboratory, and management data were collected, analyzed, and correlated with patient outcomes. Based on the Extended Glasgow Outcome Scale (GOSE), patients were assigned to have either favorable outcome (GOSE score: 5–8) or poor outcome (GOSE score: 1–4).
Results The mean age was 38.76 ± 18.30 years. The mean GCS score on admission was 11.68 ± 1.27. Surgical intervention was indicated in 29 patients (40.3%). The average length of hospital stay was 9.01 ± 7.88 days. Sixty-five patients (90.3%) had a favorable outcome and 7 patients (9.7%) had a poor outcome. Prognostic factors with significant impact on outcome included the GCS score on admission (p = 0.002); pupillary responses (p = 0.011); blood pressure (p = 0.005); acute subdural hematoma (ASDH) as a primary lesion (p = 0.049); and time to admission, comorbidities, blood glucose, hemoglobin%, oxygen saturation, coagulation profile, endotracheal intubation, and tracheostomy (p < 0.001).
Conclusion In moderate TBI patients, delayed hospital arrival, low GCS score, unequal pupils, pretrauma comorbidities, hypotension, hypoxia, anemia, endotracheal intubation, tracheostomy, and ASDH were associated with unfavorable functional recovery and could be considered as poor prognostic factors.
Navigating the Diagnostic Maze: A Case Report of Uncommon Cardiac Metastasis in Childhood Ewing Sarcoma
Authors: Narayanan Balaji , Sharma Jitendra , Ahuja Meenakshi , Kamalesh Raghavendra , Khurana Ujjawal , Malik Rajesh 
Published: November 2024

AbstractEwing sarcoma is a bone cancer affecting children and young adult males. It usually presents as a single bone tumor, but it can also occur in multiple locations. Nevertheless, Ewing sarcoma is an extremely aggressive tumor capable of metastasizing to other parts of the body, such as the lungs, bones, liver, and lymph nodes. Cardiac metastases are rare, indicating a poor prognosis, as they suggest that the cancer has become more advanced and challenging to treat.This case report describes a 9-year-old boy who presented with complaints of fever and multiple swellings in the calvaria, periorbital region, clavicle, and left thigh. Laboratory investigations revealed a high erythrocyte sedimentation rate, elevated absolute neutrophil count, high phosphate and calcium levels, and low magnesium levels. Computed tomography imaging revealed the presence of multifocal osseous expansile lytic lesions, multiple pulmonary metastases, and extensive soft tissue involvement of the heart. Based on these findings, possible differential diagnoses of Langerhans cell histiocytosis, lymphoma, and Ewing sarcoma were considered. Further histopathological examination and immunohistochemistry confirmed a final diagnosis of metastatic Ewing sarcoma.The most common metastasis sites for Ewing sarcoma are the lungs, with rare occurrences in the central nervous system, and metastasis to the heart is uncommon. We present here a rare undiagnosed Ewing sarcoma with cardiac metastasis, in addition to pulmonary and multifocal osseous metastasis. This case is unique because multifocal osseous involvement is rare and further lung and heart involvement is even rarer in Ewing sarcoma.
Creating quality portfolios using score-based models: a systematic review
Authors: Khatwani Ritesh , Mishra Mahima , Kumar V. V. Ravi , Mistry Janki , Mitra Pradip Kumar 
Published: November 2024

AbstractThis paper aims to find out if a score-based investment strategy could be developed using different scales. To achieve this objective several academic sources have been used and it is found that score-based investment not only outperforms the market but also protects the investors from the risks arising out of avoidable poor investments in the market. The project is a summary of bibliographic outcome of several scholars who have attempted to find out the impact of score-based investments in their respective markets. Score-based investments are typically dependent on accounting parameters and changes in these parameters signal that a firm’s performance is geared up for a change. The study has been done using a systematic literature review. Several research papers in peer-reviewed journals were referred starting from 1934 to 2021. Various equity-based scores like F-score, G score, L score and C score and debt-based scores like Z score, O score and M score are used for the construction of portfolios. It has been found that across geographies the use of score-based investing is known to give superior returns as compared to the market. Several pieces of literature provide the evidence. Developed countries like USA, UK, Australia, and Canada have a large concentration of literary sources that point to the evidence of score-based investing. At the same time, it is also pertinent to note that the performance of such techniques works relatively better in markets that are not efficient and where asymmetry in information flow is evident.
Groundings in French and Indonesian narrative discourses: linguistic and culture analysis
Authors: Sajarwa  
Published: November 2024

AbstractThis study conducts a comparative analysis of grounding strategies employed in French and Indonesian narrative discourse. Utilizing both qualitative and quantitative methodologies, the research draws upon a corpus of French and Indonesian novels to examine the linguistic mechanisms utilized to establish grounding in these languages. This research questions the different markers of grounding in French and Indonesian narrative discourses, the types of grounding meanings, the role of culture in grounding, and what elements can strengthen grounding. The results of the textual analysis reveal that French employs the use of tenses, specifically the passé simple and imparfait (past tenses), to convey grounding, whereas Indonesian utilizes affixes, specifically the “me(N)-” and “di-” prefixes, for the same purpose. Further, the analysis illustrates that the “me(N)-” affix can be utilized to express both backgrounding and foregrounding, while the “di-” affix is restricted to foregrounding. Additionally, Indonesian also employs the use of third-person singular pronouns—“dia” and “ia”—to enhance grounding. The contextual analysis also highlights that in Indonesian narrative discourse, there is a tendency to repeat self-names as a form of politeness. This conclusion applies to languages that use tenses (e.g., French and English) as grounding markers and applies to languages that use affixes for grounding markers (e.g., Indonesian and Malay).
Ballistic performance of TPU/steel configurations against spherical projectiles
Authors: Levadnyi Ievgen , Liu Fujia , Gu Yaodong 
Published: November 2024

In this work, we numerically and experimentally investigate the ballistic performance of thermoplastic polyurethane (TPU)/steel configurations against spherical projectiles. We chose TPU materials with high and low hardness values to form the impact-sustaining layer to investigate the ballistic performance of protective configurations. Experiments were performed by using a powder gun that shot spherical projectiles, each with a diameter of 8.4 mm, at velocities ranging from 250 to 400 m/s. A typical plug formation was observed as the failure mode of steel plates under all configurations, and we obtained curves of the ballistic limit of each configuration. The ballistic performance of the best design, featuring a TPU material with a high hardness value, was 5.8% better than that of a monolithic plate. We also separately tested materials to calibrate their models for numerical simulations. Numerical models of projectile–target systems were established by using Abaqus software and validated based on the experimental results. The results of the simulations were in good agreement with those of the experiments in terms of the failure mechanism of the configurations and residual velocity of the projectiles. Furthermore, we developed a mathematical model to accurately predict the residual velocity of the projectile after having perforated the TPU/steel configuration. It considers the thickness and hardness of the layers and the weight and initial velocity of the projectile. The predictions of our model yielded a high correlation coefficient and a low mean squared error with the results of simulations.
Polarizable force field for TiO2 based on the Drude oscillator model
Authors: Grote Fredrik , Saeedimasine Marzieh , Lyubartsev Alexander P. 
Published: November 2024

A polarizable force field has been developed for molecular dynamics simulations of titanium dioxide in an aqueous environment. The force field uses the standard functional form with an additional term accounting for polarizability, i.e., induction interaction, and has been derived exclusively from ab initio calculations by partitioning of electron density. Polarizability is described using the Drude oscillator model where each non-hydrogen atom is represented by two point charges connected by a harmonic potential. It is demonstrated that the force field provides a realistic description of the structure of anatase and rutile bulk materials from x-ray experiments. In addition, it is shown that, when combined with the popular SWM4-NDP polarizable water model, the force field describes the water structure at the titanium dioxide–water interface in agreement with results from ab initio molecular dynamics simulations. Importantly, our new model provides significant improvement of results for water differential adsorption enthalpy measured by calorimetry experiments compared to previous non-polarizable force field. The new force field allows for accurate simulations of titanium dioxide–aqueous interfaces for systems of a size of ∼105 atoms and simulation times up to the microsecond time scale.
An ethnographic Linguistic Landscape analysis of a Berlin street market
Authors: Duman Çakır İrem 
Published: November 2024

Abstract
This study investigates the diverse Maybachufer Market in Berlin using an ethnographic Linguistic Landscape (LL)
analysis that integrates quantitative and qualitative approaches. The paper focuses on the complex interplay between social
dynamics at the macro-, meso-, and micro-levels and language use in this multilingual and multiethnic urban space. The market
signs mirror social and spatial settings and relevant language attitudes. The linguistic choices are shaped by and oriented
towards (1) national language ideologies despite the multilingual and multiethnic environment; (2) dominant market
languages; and (3) commercial gain, targeting specific customers and enhancing marketing strategies. By focusing on language
attitudes and language use on market signs, this paper provides insights into the semiotic relevance of signs, societal language
ideologies, and local communicative practices in multiethnic urban settings, contributing to the broader discourse on societal
multilingualism and the benefits of ethnographic LL analyses in capturing the essence of diverse urban spaces.
Family language policy and the design of homescape in transnational families
Authors: Wang Nanfei , Yu Yin 
Published: November 2024

Abstract
Building upon previous research on family language policy, this study explores the homescape, pertinent to the
Chinese home literacy environment within Chinese transnational families. It categorizes various forms of Chinese literacy
homescape and examines parental perspectives and agency in the design, creation, and adaptation of the homescape within their
households. The study draws on ethnographic data from four Chinese-speaking families residing in France and Germany. Data includes
sound recordings of family interactions, photographs, in-depth interviews and field notes from discussions with family members.
Adopting the lens of ethnographic Linguistic Landscape, the study categorizes the Chinese literacy homescape into four sensory
modalities: highly visible, semi-visible, soundscape, and digital and interactive. Findings reveal that parents employ highly
strategic and agentic approaches when designing the Chinese literacy homescape, demonstrating their keen awareness of the unique
characteristics of the Chinese writing system and the specific challenges their children face when learning to read Chinese.
Evolution and revolution in language and linguistics
Authors: Berns Janine , Steffens Marie , Baiwir Esther 
Published: November 2024

Abstract
The first issue of Nota BeNe explores the phenomena of evolution and revolution in language
science and in language use. Linguistics has evolved over time, making it the versatile discipline it is today, and the field
should continue to remain open to new perspectives and critically consider old habits and new approaches. Revolution, peaceful or
violent, may emerge when it comes to questions of language, power and identity. The four thematic contributions in this volume
discuss questions of evolution and revolution from different angles: by investigating attitudes on language change expressed in
Austrian newspapers, by considering Francophone Belgian pupils’ performances in a popular national dictation contest, by
unravelling the various denominations used in different domains to refer collectively to Canada’s First Nations, and by discussing
to what extent a Dynamic Approach to language could be a more beneficial approach than the commonly adopted static
perspective.
Language criticism in Austrian daily newspapers
Authors: Schoonjans Steven 
Published: November 2024

Abstract
Letters to the editors of daily newspapers are often used to criticize linguistic phenomena. This paper presents
an analysis of the language criticism in letters to the editors of three Austrian daily newspapers (Kronen Zeitung, Kleine
Zeitung, and Die Presse), focusing on the argumentative topoi used in letters expressing negative attitudes towards the linguistic
phenomena discussed. The analysis includes letters on two examples of natural language change (anglicisms, teutonisms) and on two
cases of imposed language change (gender-fair language, political correctness). It is shown that while a number of topoi are used
in both cases (mainly general topoi that consider any language change as bad), there are also a number of specific topoi
especially in the case of imposed language change, typically claiming that most people are against those changes and that we have
other, more important problems to worry about than making the language gender-fair or politically correct.
Heat Stress in Broiler Chickens
Authors: Hosseintabar-Ghasemabad Babak , Baghban-Kanani Payam , Seidavi Alireza 
Published: November 2024

Abstract
Research shows that global warming has destructive effects on the environment, human health and food security. The poultry meat industry provides approximately 37% of the world's protein needs. Challenges such as undue stress due to high environmental temperatures could disrupt bird health and potentially impact the performance and availability of poultry meat for the consumer market. A stress response is the animal's biological reaction to stimuli that disturb the body’s homeostasis and can be caused by environmental factors such as excessive heat or humidity. Increased sensitivity to heat stress in modern commercial broiler chickens is due to improved growth rate and feed conversion efficiency and consequently, the welfare of these birds can be adversely affected by conditions associated with the temperature management of broiler flocks. Increasing awareness of the negative effects of heat stress on poultry welfare, bird health and performance, and meat product quality has raised concerns among researchers, breeders, production managers, and consumers. Understanding the welfare needs of broiler chickens helps to reduce the negative effects of heat stress.

Information
© The Authors 2024
Coercivity-based analysis and its application to an inverse source problem for a subdiffusion equation with time-dependent principal parts
Authors: Jiang Daijun , Li Zhiyuan , Yamamoto Masahiro 
Published: November 2024

Abstract
In this article, we investigate an inverse source problem for subdiffusion equations with time-dependent principal parts using distributed observations. We analyze coercivity properties of fractional derivatives. As applications, we use a coercivity property to establish a Lipschitz stability estimate for an inverse problem of determining the temporal component in the source term, which is a new result to the best knowledge of the authors. Numerically, we transform the inverse source problem into an optimization framework, incorporating Tikhonov regularization to mitigate the ill-posedness of the inverse problem. We then propose an iterative thresholding algorithm to solve this optimization problem efficiently. Finally, we present several numerical experiments to validate the accuracy and the efficiency of our proposed algorithm.
Theoretical studies of two phase-independent frequency spectrum models in atomic selective photoionization processes
Authors: Lu Xiaoyong , Wang Lide 
Published: November 2024

Abstract
The laser frequency spectrum, whose full width at half-maximum in the frequency domain is the laser bandwidth, plays a critical role in atomic multi-step photoionization processes and has a significant influence on isotopic selective photoionization results. In this study, two phase-independent frequency spectrum models, that is, the mode jitter model (MJ model) based on the mode jitter phenomenon and the multi-longitudinal mode model (MLM model) based on multi-longitudinal mode output, are proposed to describe the spectral characteristics in the frequency domain. In the MJ model, it is assumed that there is a time-varying longitudinal mode in each laser pulse, with different central frequencies between adjacent pulses in the pulse train; in the MLM model, it is assumed that multiple longitudinal modes are output simultaneously with fixed central frequencies. Selective photoionization properties of these two frequency spectrum models and the chaotic field model are simulated and compared with each other under the Lorentzian frequency spectrum condition. Influences of the excitation intensity, laser frequency spectral profile and cutoff frequency on selective photoionization processes are calculated and compared among the above-mentioned three frequency spectrum models. Finally, the measurement of the laser frequency spectrum and the introduction of individual longitudinal modes’ bandwidths are discussed.
Triboplasma assisted chemical conversion in granular systems: a semi-analytic model
Authors: Sitaraman Hariswaran , Sundaresan Sankaran 
Published: November 2024

Abstract
We present a semi-analytic model for a novel plasma-assisted chemical conversion pathway using triboplasmas generated in granular flows. Triboelectric charge relaxation is a well known phenomena where the potential generated from contact charging of particles exceeds the breakdown voltage of the background gas. In this work, we extend the triboelectric charge relaxation theory to include non equilibrium plasma energy and particle balance equations to predict the formation of dissociated and excited species that act as precursors to chemical conversion, for example in plasma-assisted ammonia synthesis. Our example case study with nitrogen background gas and teflon/aluminum tribomaterial system yielded high excited nitrogen species densities per collision that are comparable to current plasma-assisted conversion pathways. We also present a regime diagram for various gases where Paschen breakdown parameters are used to determine whether triboplasmas can be formed for a given effective work-function difference between two materials. Our sensitivity studies indicate particle velocity, particle radius, solids fraction and space charge effects play a critical role in overall plasma densities and excited species production.