bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of copper doping on zinc oxide for potential use in nanowire devices
Authors: Hussain Sazzad , Carley L. Richard 
Published: October 2024

AbstractZinc oxide is a promising material in semiconductor research owing to its exceptional properties including wide band gap and high carrier mobility. We observe the effect of copper (a promising acceptor species) doping properties of zinc oxide using Density Functional Theory (DFT). Carrier concentration calculations reveal that the copper doping leads to a p-type semiconductor with an increase in hole concentration to the order of 1018 cm−3. The resultant structure is used to build junctionless nanowire transistors. These nanoscale devices exhibit excellent characteristics including a diameter-normalized on-current of more than 500 μA/μm and an on-current to off-current ratio of greater than 5 × 106 for select configurations. In addition, several design parameters are varied, and guidelines are presented that offer improved performance.
Graphical abstract
Fig. a Copper-doped zinc oxide junctionless transistor (UL represents source/drain underlap) b Cross-sectional view c Drain current vs gate voltage for one of the devices
ВИКОРИСТАННЯ МЕТОДОЛОГІЙ IDEF0 ТА DFD ПРИ ПРОЕКТУВАННІ ПРОГРАМНОГО ЗАСОБУ ВЕДЕННЯ ЕЛЕКТРОННОЇ КОМЕРЦІЇ
Authors: Москаленко С. С. , Котлик С. В. , Корнієнко Ю. К. 
Published: October 2024

Анотація: Дана стаття присвячена використанню методологій IDEF0 (Integrated DEFinition) та DFD (Data Flow Diagrams) у процесі проектування програмного засобу для ведення електронної комерції. Вказано, що IDEF0 дозволяє моделювати бізнес-процеси у вигляді ієрархічної структури функцій, що сприяє зрозумінню зв'язків між ними та оптимізації процесів. DFD використовується для аналізу потоків даних та їх обробки у системі, що є важливим при проектуванні програмного засобу.
У роботі розглядається сучасний стан електронної комерції та визначаються основні вимоги до програмного забезпечення для її підтримки. Далі досліджується методологія IDEF0, її принципи та основні концепції, які можна використовувати для моделювання бізнес-процесів в електронній комерції. Також, у роботі детально аналізується методологія DFD, її етапи та засоби, які вона надає для моделювання потоків даних у програмному забезпеченні.
Основна увага приділяється практичному застосуванню цих методологій у проектуванні програмного засобу. На конкретних прикладах показано, як можна використовувати IDEF0 та DFD для аналізу, проектування та реалізації програмного засобу для ведення електронної комерції. Робота включає в себе опис процесу моделювання бізнес-процесів, аналіз вимог до програмного забезпечення та проектування структури даних.
Дослідження показало, що використання методологій IDEF0 та DFD при проектуванні програмного засобу ведення електронної комерції дозволяє ефективно моделювати бізнес-процеси та аналізувати потоки даних у системі, що сприяє покращенню якості розробки та забезпеченню високої функціональності програмного засобу. Робота може бути корисною для студентів, викладачів та спеціалістів у галузі програмування та інформаційних технологій, які цікавляться розробкою програмного забезпечення для електронної комерції.
ANALYZING USER BEHAVIOR PATTERNS FOR PERSONALIZED RECOMMENDER SYSTEMS IN E-COMMERCE: A LITERATURE REVIEW
Authors: Nesterov Vasyl 
Published: October 2024

Abstract: E-commerce thrives on a user-centric strategy, and recommender systems are at the cutting edge of personalizing the purchasing experience. These systems may forecast preferences and recommend appropriate items by analyzing user behavior patterns, resulting in many benefits such as increased customer satisfaction, increased sales and conversions, and increased efficiency. To accomplish these benefits, recommender systems utilize complex algorithms that examine numerous elements of user behavior such as purchase history, browsing behavior, search queries, demographic data, and implicit feedback. Sophisticated algorithms can recognise complicated patterns in user data, resulting in more accurate and personalized suggestions. Analyzing user reviews, product descriptions, and social media interactions may help you better understand consumer preferences and product features. Systems can make real-time suggestions depending on a user’s current browsing session, resulting in a more dynamic purchasing experience. Personalized recommender systems will play an increasingly important role in molding the future of e-commerce as user behavior analysis techniques are constantly refined.
The study intends to make important advances to the field of personalized recommender systems by undertaking a thorough research of user behavior patterns in the e-commerce domain. We strive to improve the performance of recommender systems by extracting insightful features from various data sources and exploring sophisticated machine learning techniques, resulting in a more engaging and tailored user experience that fosters customer satisfaction and drives business growth.
A comprehensive review of user behavior patterns and their influence on personalized recommender systems in the e-commerce industry reveals the critical role of data analysis and machine learning algorithms in tailoring product suggestions to individual preferences, thereby enhancing customer satisfaction and driving sales growth.
By implementing the tactics and approaches expressed in this study, e-commerce platforms may stay ahead of the curve, providing a smooth and tailored purchasing experience that surpasses customer expectations and contributes to their competitive advantage in the changing e-commerce environment.
Efficacy and Safety of Ravulizumab in IgA Nephropathy
Authors: Lafayette Richard , Tumlin James , Fenoglio Roberta , Kaufeld Jessica , Pérez Valdivia Miguel Ángel , Wu Mai-Szu , Susan Huang Shih-Han , Alamartine Eric , Kim Sung Gyun , Yee Min , Kateifides Andreas , Rice Kara , Garlo Katherine , Barratt Jonathan ,   the SANCTUARY Study Investigators
Published: October 2024

Key Points

This phase 2, double-blind, randomized controlled trial evaluated the complement C5 inhibitor, ravulizumab, in adults with IgA nephropathy.A 30.1% (90% confidence interval, 13.7% to 43.5%) relative reduction in proteinuria for ravulizumab versus placebo was observed at approximately 6 months.Treatment with ravulizumab was well tolerated.

Background
The complement system plays a central role in the pathogenesis of IgA nephropathy. We present findings from a phase 2 trial of ravulizumab, a complement C5 inhibitor.

Methods
The Study of Ravulizumab in Proliferative Lupus Nephritis or IgA Nephropathy (NCT04564339) was a randomized, double-blind, placebo-controlled trial of ravulizumab in addition to standard of care. Adults with IgA nephropathy, proteinuria ≥1 g/d, and eGFR ≥30 ml/min per 1.73 m2, and on stable renin-angiotensin blockade were randomized 2:1 to ravulizumab (intravenous every 8 weeks) or placebo for 26 weeks. From week 26–50, all participants received open-label ravulizumab. The primary end point was percentage change in proteinuria from baseline to week 26. Secondary end points included change in proteinuria at week 50 and eGFR. Safety, pharmacokinetics, and pharmacodynamics were evaluated.

Results
Forty-three patients were randomized to ravulizumab and 23 to placebo. At week 26, a statistically significant reduction in proteinuria was observed with ravulizumab versus placebo: −41.9% (95% confidence interval [CI], −50.2% to −32.0%) change in urine protein with ravulizumab and −16.8% (95% CI, −31.8% to 1.6%) change with placebo (30.1% treatment effect; P = 0.005). At week 50, there was a −44.8% (95% CI, −55.1% to −32.1%) change from baseline in urine protein with ravulizumab, and in patients who crossed over from placebo to ravulizumab at week 26, the change from baseline (week 0) to week 50 was −45.1% (−58.0% to −28.4%). The least squares mean change in eGFR from baseline to week 26 with ravulizumab was 0.2 (95% CI, −2.3 to 2.7) ml/min per 1.73 m2 and with placebo was −4.5 (−7.9 to −1.1) ml/min per 1.73 m2. From baseline to week 50, the least squares mean change in eGFR with ravulizumab was −3.9 (95% CI, −6.4 to−1.3) ml/min per 1.73 m2, and in patients who crossed over from placebo to ravulizumab at week 26, it was −6.3 (−9.7 to −2.9) ml/min per 1.73 m2. Ravulizumab was well tolerated, with an adverse event profile similar to that for placebo.

Conclusions
An early, sustained, and clinically meaningful reduction in proteinuria and trend toward stabilization of eGFR were observed with ravulizumab versus placebo. A phase 3 trial (NCT06291376) is enrolling.

Clinical Trial registry name and registration number:
Study of Ravulizumab in Proliferative Lupus Nephritis or IgA Nephropathy, NCT04564339.
Essential public health competencies in nursing during the COVID-19 pandemic: A Delphi study
Authors: López Consuelo Burbano , Sotelo-Daza Jorge 
Published: October 2024

Background & Aim: Nursing practice, characterized by its multifaceted nature, encompasses diverse settings and situations in public health, making it difficult to clearly define the role of nurses in this setting. The study aimed to determine the applicability and relevance of the Regional Core Competency Framework for Public Health in nursing practice during the COVID-19 pandemic.
Methods & Materials: Study based on the Delphi methodology, a structured approach to the systematic collectión of expert opinions, to obtain group agreements. Twenty-one nurses working in public health areas during the pandemic participated.
Results: The competencies most applied by the nurses were in the domain of health situation analysis and surveillance and risk and damage control. 95% of the nurses were involved in care actions to prevent contagion; 71% analyzed social determinants of health, 100% were involved in the domain of policies, planning, regulation, and control, and 86% in the domain of health promotion. 89% made decisions to favor access to preventive and health care services. 78% valued social participation actions and 76% implemented immediate responses to COVID-19.
Conclusion: The main public health competencies used by nursing for dealing with the COVID-19 pandemic are the management of educational processes, health promotion, primary health care, analysis of social determinants, management of health policies, information analysis, and management of immediate responses to challenges generated by COVID-19.
Pengaruh Disiplin Kerja, Motivasi Kerja dan Lingkungan Kerja Terhadap Kinerja Karyawan di PT Sentra Agroprima Lestari
Authors: Romadhona Anna Bella Claudia , Iristian Jovi , Adistie Gisti Riza 
Published: October 2024

The purpose of this research is to examine how the influence of the work environment and work discipline on employee performance. Employees of PT Sentra Agroprima Lestari Surabaya became the research subjects. This study uses quantitative research methods as its methodology. This type of research uses a quantitative approach and uses primary data. The population of the research was 35 employees of PT Sentra Agroprima Lestari Surabaya. The sampling technique in this research uses saturated samples, namely a sampling technique that uses all members of the population as samples. Data collection through questionnaires. The analysis method used is the Statistical Product and Service Solution (SPSS) method.
Keywords: Work Discipline, work motivation, work environment and performance
Male-specific lethal 1 (MSL1) promotes Erastin-induced ferroptosis in colon cancer cells by regulating the KCTD12-SLC7A11 axis
Authors: Liang Bing , Luo Lifu , Dong Shijiao , Wang Yong , Zhao Qingzhi , Jiang Nan , Cui Xueli , Jin Jingji 
Published: October 2024

Abstract

MSL1, a scaffold protein of the histone acetyltransferase MSL complex, plays a crucial role in the structural integrity and enzyme activity of the complex. Although it has shown that MSL1 is highly expressed in various primary tumor tissues, its role and molecular mechanism in the occurrence and development of tumors, as well as its impact on the process of tumor cell death, are not yet fully understood. Herein, we presence evidence for the first time from systematic biochemical assays and knockdown/overexpression approaches arguing that a negative regulatory mechanism exists between MSL1 and KCTD12. Interestingly, in HCT116 colon cancer cells, the expression of MSL1 was dramatically inhibited by the ferroptosis inducer Erastin, leading to upregulation of KCTD12 expression. Meanwhile, MSL1 promotes Erastin induced ferroptosis in HCT116 cells by regulating the KCTD12-SLC7A11 axis. In line with this, the ROS, GSH, and MDA levels induced by Erastin were impacted by the MSL1-KCTD12-SLC7A axis, suggesting the involvement of this axis in Erastin induced ferroptosis in colon cancer cells. Our findings will provide new therapeutic targets and theoretical basis for clinical colon cancer.
Impact of copper (I) Nicotinate complex on Notch signaling pathway in autophagy-modulated triple-negative breast cancer cell lines
Authors: Abdel-Mohsen Mohamed A. , Badawy Asmaa , Abu-Youssef Morsy A. , Yehia Mona A. , Shamaa Lobna D. Abou , Mohamed Shymaa A. 
Published: October 2024

Abstract

Background: Triple-negative breast cancer (TNBC) is the most aggressive subtype and is distinguished by a short overall survival, chemoresistance, recurrence, and a poor prognosis. Despite the increase in the disease's incidence globally, the development of numerous targeted medications and innovative combination therapies has improved the overall prognosis for individuals with breast cancer. However, this generally encouraging image is tarnished by the development of resistance or the reduced effectiveness of pharmaceutical combinations, even if the basic processes are not understood. For instance, autophagy, a catabolic process intended to recycle damaged cellular components and provide energy, is quickly activated by cancer cells to evade most therapies. Consistent with this theory, there is a rising need for metal substances such as copper complex, which may promote cell death and have a less harmful effect on normal cells. On the other hand, deregulated Notch signaling within the breast tumor and its microenvironment is linked to poor clinical outcomes in the treatment of resistant breast cancer.
Objectives: In autophagy-modulated TNBC cell lines, the current study aimed to clarify the possible significance of copper (I) nicotinate complex (CNC) as a targeted therapy for the Notch signaling pathway and evaluated any potential communication between the autophagic process and the Notch signaling pathway.
Method: Two distinct TNBC cell lines, HCC1806 and MDA-MB231 cells, were used. To assess the autophagy process, Torin1 was used to stimulate autophagy, while chloroquine was used to inhibit it. The MTT assay was used to determine the cytotoxicity of CNC and the reference treatment, doxorubicin. The indirect antibody labeling of microtubule-associated protein light chain 3 (LC3) was measured using flow cytometry. The Notch signaling pathway-related gene expressions were determined using real-time PCR technique.
Results and conclusion: Treatment of TNBC cells with the CNC-modulated Notch signaling pathway significantly differed depending on the type of cell line and CNC concentration used. In conclusion, given CNCs’ concentration and use with Doxo, it may be a viable targeted anticancer treatment for TNBC due to its ability to inhibit Notch signaling in autophagy-modulated TNBC.
Role of job burnout and work engagement in the relationship between mental health literacy and life satisfaction in Chinese Barefoot Social Workers: A serial mediation model based on the job demands-resources theory
Authors: Yang Jia , Chen Yang , Zou Ya , Liu Jingjing , Mao Lang , Peng Lianhua , Mao Ping 
Published: October 2024

Abstract

Background
Barefoot social workers play an essential role in providing child welfare services, and their life satisfaction is critical but often ignored. Mental health literacy has been shown to be associated with life satisfaction, yet the mechanisms underlying such an association remain understudied. Guided by the job demands-resources (JD-R) theory, this study aimed to investigate the mediating effects of job burnout and work engagement in the relationship between Chinese barefoot social workers' mental health literacy and life satisfaction for the first time.
Methods
A retrospective cross-sectional study involving 1252 Chinese barefoot social workers was conducted from April to June 2023. Pearson's bivariate correlation analysis was conducted to identify correlations. The mediating effect was analyzed using SPSS PROCESS v.4.3.
Results
The correlation analysis results showed that mental health literacy (r = 0.12, p < 0.01), job burnout (r=-0.14, p < 0.01), and work engagement (r = 0.46, p < 0.01) were significantly associated with life satisfaction. Job burnout and work engagement serially and partially mediated the association between mental health literacy and life satisfaction, with a total indirect effect of 0.071 (95%CI:0.056 ~ 0.087).
Conclusion
Our findings support the potential mediating roles of job burnout and work engagement in the relationship between mental health literacy and life satisfaction. These findings hold significant implications for devising effective and targeted psychological intervention programs to improve life satisfaction among Barefoot social workers.
Effect of the defocus ring area after orthokeratology lens wear on the progression of adolescent myopia Running title: The defocus ring area after OK lens wear and myopia control
Authors: Hu Jie , Li Xuewei , Yan Huichao , Li Jingxin , Xu Mengyao 
Published: October 2024

Abstract

Objective
Orthokeratology (OK) lenses are one of the most effective optical treatments for myopia control. Herein, this study investigated the effect of the defocus ring area after OK lens wear on the progression of myopia in adolescents.
Methods
A total of 180 myopic adolescents were randomized into control (wearing frame glasses) and OK lens groups (90 cases per group). The diopter, ocular axial length, and visual quality of participants were recorded. The Spearman's correlation, multivariate logistic regression, and ROC analyses were performed to assess effect of the defocus ring area on the progression of myopia (growth of the ocular axis and diopter) and its predictive value for the progression of myopia.
Results
The increase in the growth of ocular axial length and diopter was significantly slowed after 1 year of lens wear. Additionally, the visual quality was not affected after 1 year of OK lens wear. The defocus ring area was positively correlated with the growth of the ocular axis and the diopter after 1 year of OK lens wear. The increased defocus ring area after OK lens wear was an independent risk factor for poor myopia control. The defocus ring area could aid in predicting myopia progression in adolescents (cutoff value, 22.05) with high AUC, sensitivity, and specificity.
Conclusion
The defocus ring area after OK lens wear is an independent risk factor for myopia progression in adolescents and can assist in predicting myopia progression after 1 year of lens wear.
Observation of anodic bubble behavior using laboratory scale transparent aluminum electrolysis cells
Authors: huang yipeng , yang jun , liu qingsheng 
Published: October 2024

Abstract

In the Hall-Héroult process for extracting aluminum, the generation of anodic bubbles is an inherent phenomenon in the electrolysis process. In this study, the bubble dynamics beneath the anode during aluminum electrolysis were studied using the bottom-observation transparent electrolysis cell. The bubble formation, growth and release processes underneath the anode were recorded by video cameras, and the relevant characteristic parameters of bubbleswere obtained using image processing. It was found that bubble evolution occurs preferentially at specific locations on the anode's underside, suggesting that bubble nucleation is not a random process. Additionally, coalescence was observed during bubble growth when two bubbles collided, and this phenomenon confirms that bubble coalescence is a significant pathway for bubble growth. The bubble coverage decreased first and remain unchanged later with increasing current density. At current densities exceeding 0.9 A/cm², the gas coverage is approximately 50%. Furthermore, a correlation was established between voltage fluctuations and the escape of gas bubbles, indicating that bubbles are a key factor contributing to voltage fluctuations during the electrolysis process. The additional resistance introduced by the bubbles was found to be closely associated with both bubble coverage and size. This study enhances our understanding of anodic bubble behavior in aluminum electrolysis and lays a theoretical groundwork for optimizing the electrolysis process.
Characterization of the multiplicity of solutions for camera pose given two vertically-aligned landmarks and accelerometer
Authors: Pruss Alexander Robert 
Published: October 2024

Abstract

We consider the problem of recovering the position and orientation of a camera equipped with an accelerometer from sensor images of two labeled landmarks whose positions in a coordinate system aligned in a known way with gravity are known. This a variant on the much studied PnP problem of recovering camera position and orientation from n points without any gravitational data. It is proved that in three types of singular cases there are infinitely many solutions, in another type of case there is one, and in a final type of case there are two. A precise characterization of each type of case. In particular, there is always a unique solution in the practically interesting case where the two landmarks are at the same altitude and the camera is at a different altitude. This case is studied by numerical simulation and an implementation on a consumer cellphone. It is also proved that if the two landmarks are unlabeled, then apart from the same singular cases, there are still always one or two solutions.
UBE2E2 targets HMGB1 to regulate cardiomyocyte ferroptosis in experimental autoimmune myocarditis mice to exert a protective effect
Authors: Yang Yiheng , Yin Bokai , Yang Peng , Zheng Zhenzhong , Tian Qingshan 
Published: October 2024

Abstract

Autoimmune myocarditis is a potentially life-threatening disease mediated by myocardial immune injury that can evolve into dilated cardiomyopathy and end-stage heart failure. Numerous studies have shown that ferroptosis is involved in the pathogenesis of several cardiovascular diseases, including heart failure, myocardial infarction, and myocardial fibrosis. However, the involvement of ferroptosis in experimental autoimmune myocarditis (EAM) has a mechanism that is still unclear. In this study, we successfully constructed animal and cellular models of EAM and found that ubiquitin-conjugating enzyme E2E2 (UBE2E2) was lowly expressed in EAM, and that cardiomyocyte ferroptosis was involved in the pathological development of EAM; overexpression of UBE2E2 inhibited inflammatory infiltration and ferroptosis of cardiomyocytes in EAM mice, and significantly improved cardiac remodeling and function. In in vitro experiments, UBE2E2 overexpression increased considerably cell proliferation viability, effectively reduced ROS levels in cardiomyocytes, and enhanced mitochondrial number, morphology, and membrane potential changes. Mass spectrometry screened the UBE2E2 ferroptosis-related interacting protein as HMGB1, and UBE2E2 could inhibit the progression of EAM by ubiquitination degradation of HMGB1. In conclusion, our results suggest that UBE2E2 may inhibit ferroptosis in EAM cardiomyocytes by targeting HMGB1, thereby exerting a protective effect on EAM and providing a new potential target for EAM therapy.