bluuebunny/crossref_metadata_2025_split huggingface dataset:
Key metabolic parameters change significantly in early breast cancer survivors: an explorative PILOT study
Authors: Fredslund Stine Overvad , Gravholt Claus Højbjerg , Laursen Britt Elmedal , Jensen Anders Bonde 
Published: April 2019

Abstract
Background
With increasing number of breast cancer survivors, more attention is drawn to long-term consequences of curative cancer treatment. Adjuvant treatment of breast cancer patients is associated with several unfavorable medical conditions, including dyslipidemia, insulin resistance, and obesity, potentially leading to cardiovascular disease and/or the metabolic syndrome. The aim of this explorative study is to investigate metabolic side effects of adjuvant treatment in breast cancer patients.

Methods
A cohort of 13 premenopausal and 20 postmenopausal women with early stage breast cancer were extensively examined prior to, immediately after and 1 year after ended adjuvant chemotherapy and compared with healthy controls (N = 36) matched by age and menopausal status. Repeated examinations included: anthropometric measures, DEXA scans, 24-h blood pressure measurements, and blood samples [high sensitivity CRP, lipid profile and glucose metabolism, including homeostatic model assessment (HOMA)].

Results
At baseline, breast cancer patients were similar to healthy controls regarding all measures. From baseline to 1-year post-treatment specific components of the metabolic syndrome increased significantly in premenopausal breast cancer patients; body fat (P = 0.01), triglycerides (P = 0.03), waist circumference (P = 0.008) and diastolic blood pressure (P = 0.04). In postmenopausal patients, waist circumference also increased significantly (P = 0.03), and High density lipoprotein (HDL) cholesterol decreased significantly (P = 0.05).

Conclusions
Specific components of the metabolic syndrome changed significantly during chemotherapy in early stage breast cancer patients. After 1 year, several key parameters remained pathologically changed. Premenopausal breast cancer patients seemed to be especially prone to develop these unfavorable changes.
Trial registration ClinicalTrial.gov, registration number NCT02652975. Registered 15 December 2015—Retrospectively registered, https://clinicaltrials.gov/.
Acute Exercise Increases Plasma Levels of Muscle-Derived Microvesicles Carrying Fatty Acid Transport Proteins
Authors: Nielsen Morten Hjuler , Sabaratnam Rugivan , Pedersen Andreas James Thestrup , Højlund Kurt , Handberg Aase 
Published: April 2019

AbstractContextMicrovesicles (MVs) are a class of membrane particles shed by any cell in the body in physiological and pathological conditions. They are considered to be key players in intercellular communication, and with a molecular content reflecting the composition of the cell of origin, they have recently emerged as a promising source of biomarkers in a number of diseases.ObjectiveThe effects of acute exercise on the plasma concentration of skeletal muscle-derived MVs (SkMVs) carrying metabolically important membrane proteins were examined.ParticipantsThirteen men with obesity and type 2 diabetes mellitus (T2DM) and 14 healthy male controls with obesity exercised on a cycle ergometer for 60 minutes.InterventionsMuscle biopsies and blood samples—obtained before exercise, immediately after exercise, and 3 hours into recovery—were collected for the analysis of long-chain fatty acid (LCFA) transport proteins CD36 (a scavenger receptor class B protein) and fatty acid transport protein 4 (FATP4) mRNA content in muscle and for flow cytometric studies on circulating SkMVs carrying either LCFA transport protein.ResultsBesides establishing a flow cytometric approach for the detection of circulating SkMVs and subpopulations carrying either CD36 or FATP4 and thereby adding proof to their existence, we demonstrated an overall exercise-induced change of SkMVs carrying these LCFA transport proteins. A positive correlation between exercise-induced changes in skeletal muscle CD36 mRNA expression and concentrations of SkMVs carrying CD36 was found in T2DM only.ConclusionsThis approach could add important real-time information about the abundance of LCFA transport proteins present on activated muscle cells in subjects with impaired glucose metabolism.
Ice Thieves
Authors: Shewry Teresa 
Published: April 2019

Abstract
Navigating humor’s potentials for violence and for creative and critical connections with oceanic catastrophes, from extinctions to sea-level rise, this essay argues that humor is a diverse and perhaps important dimension of contemporary cultural production about the changing oceans. Jane Rawson’s A Wrong Turn at the Office of Unmade Lists uses humor to emphasize fictional people’s challenging and idiosyncratic daily struggles to survive in a future marked by sea-level rise and other climate-related processes. The novel’s absurd tragicomic tensions situate climate change as violence that is, at some level, unrepresentable. Its humor stresses not only the immense difficulties faced by characters who navigate in this future but also the deep socioeconomic inequality with which such difficulties are bound up, opening the narrative toward efforts to achieve climate justice.
The Bolivian Toba (Guaicuruan) Expansion in Northern Gran Chaco, 1550–1850
Authors: Mendoza Marcela 
Published: April 2019

Abstract
The Bolivian Tobas in northern Gran Chaco were mobile hunter-gatherers organized in bands. They called themselves qomleʔk, and spoke a distinctive variation of Guaicuruan language. For three hundred years, coalitions of Toba braves successfully rejected Jesuit missionaries, alternatively fought and aligned with neighboring groups, and resisted the advance of colonial settlers. However, little is known about the remote past of these resilient peoples, who became mounted foragers in the early 1600s. A careful review of historical, ethnographic, and linguistic records on Tobas around the Upper Pilcomayo River produced a considerable amount of information, pointing to the long-term continuity of their presence in the region. The materials were less informative on cultural and social changes in their society through time. This study presents new insights on Toba bands trekking territories on the Manso Plains,
Adaptation, fitness landscape learning and fast evolution
Authors: Reinitz John , Vakulenko Sergey , Grigoriev Dmitri , Weber Andreas 
Published: April 2019

We consider evolution of a large population, where fitness of each organism is defined by many phenotypical traits. These traits result from expression of many genes. Under some assumptions on fitness we prove that such model organisms are capable, to some extent, to recognize the fitness landscape. That fitness landscape learning sharply reduces the number of mutations needed for adaptation. Moreover, this learning increases phenotype robustness with respect to mutations, i.e., canalizes the phenotype. We show that learning and canalization work only when evolution is gradual. Organisms can be adapted to many constraints associated with a hard environment, if that environment becomes harder step by step. Our results explain why evolution can involve genetic changes of a relatively large effect and why the total number of changes are surprisingly small.
A bilayer tissue culture model of the bovine alveolus
Authors: Lee Diane , Chambers Mark 
Published: April 2019

The epithelial lining of the lung is often the first point of interaction between the host and inhaled pathogens, allergens and medications. Epithelial cells are therefore the main focus of studies which aim to shed light on host-pathogen interactions, to dissect the mechanisms of local host immunity and study toxicology. If these studies are not to be conducted exclusively in vivo, it is imperative that in vitro models are developed with a high in vitro-in vivo correlation. We describe here a co-culture bilayer model of the bovine alveolus, designed to overcome some of the limitations encountered with mono-culture and live animal models. Our system includes bovine pulmonary arterial endothelial cells (BPAECs) seeded onto a permeable membrane in 24 well Transwell format. The BPAECs are overlaid with immortalised bovine alveolar type II epithelial cells and the bilayer cultured at air-liquid interface for 14 days before use; in our case to study host-mycobacterial interactions. Characterisation of novel cell lines and the bilayer model have provided compelling evidence that immortalised bovine alveolar type II cells are an authentic substitute for primary alveolar type II cells and their culture as a bilayer in conjunction with BPAECs provides a physiologically relevant in vitro model of the bovine alveolus. The bilayer model may be used to study dynamic intracellular and extracellular host-pathogen interactions, using proteomics, genomics, live cell imaging, in-cell ELISA and confocal microscopy. The model presented in this article enables other researchers to establish an in vitro model of the bovine alveolus that is easy to set up, malleable and serves as a comparable alternative to in vivo models, whilst allowing study of early host-pathogen interactions, currently not feasible in vivo. The model therefore achieves one of the 3Rs objectives in that it replaces the use of animals in research of bovine respiratory diseases.
Estimating malaria disease burden in the Asia-Pacific
Authors: Maude Richard James , Mercado Chris Erwin Gran , Rowley Jennifer , Ekapirat Nattwut , Dondorp Arjen 
Published: April 2019

Background: The Asia-Pacific aims to eliminate malaria by 2030. Many of the 22 endemic countries have earlier targets. To track progress towards elimination and predict timelines and funding required it is essential to have an accurate picture of the true burden of malaria over time. Estimating this is a major challenge with most countries having incomplete data on numbers of cases and wide variation between health system access and performance. Regular estimates are published by the World Health Organization (WHO), but these are not split by species, can have a wide range of uncertainty, change over time and are not available for every year. Methods: For the Asia Pacific Leaders Malaria Alliance, the burden of malaria for the 22 malaria-endemic countries in the Asia-Pacific from 2000 to 2015 was estimated by combining data submitted by countries to WHO with a systematic review to estimate the proportion of cases recorded. Due to a lack of suitable data, it was only possible to apply this method to 2013-2015. A simplified method was then derived to estimate the annual burden of falciparum and vivax malaria as inputs to a mathematical model to predict the cost of elimination, which is described elsewhere. Results: The total number of estimated cases was around double the number of confirmed cases reported in the Asia Pacific with a broad range of uncertainty around these estimates due primarily to sparsity of data with which to estimate proportions of cases reported. The ranges of estimated burdens were mostly like those published for countries by WHO, with some exceptions. Conclusions: The accuracy and precision of malaria burden estimates could be greatly improved by having more regular large surveys on access to healthcare in malaria-endemic areas and making subnational data on malaria incidence and reporting completeness publicly available.
¿Cómo perciben los estudiantes universitarios el trabajo en grupo?
Authors: García Hernández María Luisa , Porto Currás Mónica 
Published: April 2019

La Universidad como institución ha sufrido cambios significativos vinculados con la incorporación del Espacio Europeo de Educación Superior (EEES), entre los que destaca el fomento del trabajo en grupo entre los estudiantes.Así pues, este artículo se centra en conocer cómo funcionan los grupos de trabajo en la Universidad, con qué periodicidad se reúnen para realizar las tareas, dónde su congregan, qué ocurre mientras estén elaborando los trabajos y qué valoración hacen los estudiantes de esta metodología de trabajo en grupo. Para recoger la información, nos centramos en una titulación de la Universidad de Murcia, empleando un cuestionario cerrado (adhoc) y analizamos los datos obtenidos con el paquete estadístico SPSS. Entre los resultados más destacados resaltan la coherencia existente en la periodicidad de las reuniones con periodos lectivos, las ubicaciones para realizar las reuniones de trabajos son habitualmente lugares próximos a la Universidad y los estudiantes reconocen que el trabajo en equipo supone un aprendizaje relevante, aunque en menor medida influye en sus calificaciones.
Acute Phlegmonous Esophagogastritis Causing Respiratory Distress
Authors: KO Rohit , Baby Jacob , Valsalan K Praveen 
Published: April 2019

ABSTRACT
Phlegmonous esophagogastritis is an extremely rare condition characterized by diffuse inflammation of the upper gastrointestinal tract, sparing the mucosa. Patients can present with an acute onset of symptoms, and computed tomography scans can show diffusely edematous wall with intramural low attenuation surrounded by ring enhancement. Here we report such a case of a man who presented with central chest pain and breathing difficulty. The patient developed respiratory distress due to compression of trachea by the edematous esophagus.
Varicella Zoster Virus Esophagitis in an Immunocompetent Patient
Authors: Shallal Anita , Patel Prashant , Reaume Michael , Tariq Tooba , Garg Deepak 
Published: April 2019

ABSTRACTThe varicella zoster virus is highly infectious, spreading via direct contact or respiratory droplets, and can lead to life-threatening complications. Although disseminated disease tends to occur most commonly in immunocompromised patients, we present a peculiar case of varicella zoster esophagitis in a healthy, immunocompetent adult. To provide prompt treatment, clinicians should be aware that the varicella zoster virus could cause severe esophagitis, even in immunocompetent patients.
Interfaces adaptativas personalizadas para brindar recomendaciones en repositorios de objetos de aprendizaje
Authors: Salazar Ospina Oscar Mauricio , Rodríguez Marín Paula Andrea , Ovalle Carranza Demetrio Arturo , Duque Méndez Néstor Darío 
Published: April 2019

Contexto: existen muchos repositorios de recursos educativos que permiten buscar y recuperar objetos de aprendizaje, de esta forma se puede tener acceso a millones de recursos educativos; sin embargo, se requiere mejorar la presentación, visualización y satisfacción de uso de dichos objetos de aprendizaje, teniendo en cuenta las preferencias y necesidades de los estudiantes.Método: el objetivo de este artículo es incorporar una interfaz adaptativa personalizada a un sistema multiagente con el fin de recomendar objetos de aprendizaje, desde repositorios locales y remotos utilizando el perfil cognitivo de los estudiantes.Resultados: la validación del prototipo se realizó a través de un caso de estudio en el cual la interfaz adaptó tanto la presentación como la visualización de los objetos de aprendizaje a través de las preferencias, necesidades y características de los estudiantes.Conclusiones: se puede concluir que las interfaces adaptativas personalizadas demuestran su eficacia y representan entonces un gran aporte en los entornos de e-learning, debido a que modifican en tiempo real la visualización y la presentación, teniendo en cuenta el perfil cognitivo del aprendiz.
Assessment of Compost Maturity using The Static Respirometry Index
Authors: Kristanto Gabriel Andari , Rahmah Syifa Aulia 
Published: April 2019

To be used as organic fertilizer, compost must be stable and mature enough to ensure that it is safe for agricultural application. The stability and maturity of compost can be viewed from physical, chemical, and biological parameters. One of the biological parameters is the static respiration index (SRI). In many places, the SRI is applied as a representative indicator of the stability and maturity of compost but not in Indonesia compost standard of the SNI 19-7030-2004. This study aims to assess the index of the static respiration of composts and analyze their stability and maturity. The assessment was carried out on 10 compost samples sold in Jakarta and Depok. It is observed that 8 of 10 tested composts was stable and mature, with a static respiration index of 0.61–1.35 mg O2 g-1 VS h-1. One of the 10 composts was very stable and very mature, with a static respiration index of 0.46 mg O2 g-1 VS h-1 and 1 compost was unstable and immature, with an index of 1.79 mg O2 g-1 VS h-1. The results indicated that re-composted for seven days was adequate to make the compost more stable and mature than the initial state. Since maturity is not described by a single property, it is great assurance for the compost producer and end user in Indonesia that not only physical and chemical characteristics are used as indicator for compost stability and maturity but also biological indicator such as SRI. Keywords: compost; maturity; stability; static respiration index
Estimating the effect of buyers’ bargaining power on Kenyan small food manufacturers’ income
Authors: Omillo Francis Okumu 
Published: April 2019

The purpose of this study is to predict the effect of buyers’ bargaining power (customers’ price sensitivity, knowledge level, union, ability to integrate backward, switching costs and resale buying) on incomes of small food manufacturers. A survey of perceptions of 132 sampled small food processors in Nairobi and Busia Counties was done. From the gradation of the perceptions on seven-point likert scale, inferences were made on buyers bargaining power influence on the larger population of small food manufacturers in Kenya. On one hand, the study revealed that every unit of buyer’s sensitivity to prices, not unionized, integrated backwards and bought for goods for resale accounted for a positive change small food processors’ income by 0.011, 0.013, 0.005 and 0.010, respectively. On the other hand, the study showed a negative change of 0.006 and 0.008 in incomes of small agro-food processors with every unit change in the level of buyer’s knowledge and shifted to alternative product, respectively. Using Ordinary Least Square (OLS) linear regression statistical inference, there was no single standalone buyers’-bargaining-power-factor that significant influenced incomes of small food manufacturers in Kenya. However, the amalgam of the buyers bargaining power cues actually did influence the incomes (t=8.294, p= 0.00, sig <0.05, 2 tailed). Given the findings, the study recommends that marketers of food products should treat buyers bargaining powers factors as a whole and not as individual components. Further studies should consider structural equation modeling to determine a model with critical buyers-bargaining-powers factors.
Design and implementation of a low-cost device for measuring sap flow in woody species
Authors: Cárdenas María Fernanda , López Ramírez Cristina , Mejía Juan Diego , Escobar Jhon Fredy 
Published: April 2019

Transpiration is a key variable in water balance. Sap flow measurement methods allow to estimate transpiration at plant level, but scalable at the stand, river basin or ecosystem level. This requires recording data continuously, for which there are commercial devices, but they are specialized and expensive. This document shows that it is possible to integrate a data capture, management and storage system, as a counterpart to a commercial system such as Campbell's CR-100, for measuring and recording environmental variables, with a notable reduction in costs. The methodology used to develop a device for the estimation of sap flow using the heat ratio method, the design of the Arduino-based electronic circuit and the software, with register 13-64-171 of the Dirección Nacional de Derechos de Autor, is presented.
Inovação nas práticas pedagógicas no Ensino Superior: possibilidades para promover o engajamento acadêmico
Authors: Wiebusch Andressa , Lima Valderez Marina Do Rosário 
Published: April 2019

Este trabalho analisou as produções científicas sobre a inovação no ensino superior, nas práticas pedagógicas e, a partir disso, identificou as possibilidades promover o engajamento estudantil. A investigação foi realizada por meio do Estado do Conhecimento, utilizando, para tanto, o portal da Biblioteca Digital Brasileira de Teses e Dissertações (BDTD) do Instituto Brasileiro de Informação em Ciência e Tecnologia (IBICT). O recorte temporal foi de cinco anos e o período de busca foi de 2012 até 2017. Realizou-se um mapeamento de dissertações e teses, relacionadas à temática, num estudo de abordagem qualitativa, e para a interpretação dos dados usou-se a análise de conteúdo proposta por Bardin (2009). Ao analisar as produções científicas sobre o tema da inovação, identificamos que elas apresentam estratégias pedagógicas que possibilitam a integração de metodologias de ensino e de tecnologias no ensino superior com o objetivo de contribuir para inovação dos processos de ensinoe aprendizagem na universidade. Com base nos trabalhos analisados, compreende-se que são necessários novos olhares para a inovação no ensino superior, visando a importância de práticas diferenciadas e de ações quepotencializem o engajamento acadêmico.
El verbo y la producción discursiva de los niños costarricenses de 2 a 4 años de edad
Authors: Murillo Rojas Marielos 
Published: April 2019

El verbo es una forma sintáctica, nuclear para la conversación, que posee una densa morfología (tiempo, aspecto, modo, voz, persona y número), por lo que es un referente básico al analizar el desarrollo del lenguaje de los niños. El presente artículo, de naturaleza descriptivo-transversal, tiene como objetivo identificar la acción verbal y las formas verbales temporales empleadas por 38 de niños costarricenses de 2 a 4 años en la producción de textos orales, elicitados a partir de narraciones de eventos ligados al contexto escolar y familiar, así como a la narración de cuentos infantiles.
Palabras clave: Desarrollo del lenguaje, marcadores morfológicos, tiempo verbal, aspecto verbal.
Spanish validation of the pathological buying screener in patients with eating disorder and gambling disorder
Authors: Fernández-Aranda Fernando , Granero Roser , Mestre-Bach Gemma , Steward Trevor , Müller Astrid , Brand Matthias , Mena-Moreno Teresa , Vintró-Alcaraz Cristina , Pino-Gutiérrez Amparo del , Moragas Laura , Mallorquí-Bagué Núria , Aymamí Neus , Gómez-Peña Mónica , Lozano-Madrid María , Menchón José M. , Jiménez-Murcia Susana 
Published: April 2019

Background and aims
Pathological buying (PB) is a behavioral addiction that presents comorbidity with several psychiatric disorders. Despite the increase in the prevalence estimates of PB, relatively few PB instruments have been developed. Our aim was to assess the psychometric properties of the Spanish version of the pathological buying screener (PBS) and to explore the associations between PB, psychopathology, and personality traits.

Methods
A total of 511 participants, including gambling disorder (GD) and eating disorder (ED) patients diagnosed according to DSM-5 criteria, as well as healthy controls (HCs), took part in the study.

Results
Higher PB prevalence was obtained in ED patients than in the other two study groups (ED 12.5% vs. 1.3% HC and 2.7% GD). Confirmatory factor analysis (CFA) verified the 13-item structure of the PBS, and indexes of convergent and discriminant capacity were estimated. CFA confirmed the structure in two factors (excessive buying behavior and loss of control) with excellent internal consistency (α = .92 and .86, respectively). Good convergent capacity was obtained with external psychopathology and personality measures (positive correlations with novelty seeking and negative associations with self-directedness and harm avoidance were found). Good discriminative capacity to differentiate between the study groups was obtained.

Discussion and conclusions
This study provides support for the reliability and validity of the Spanish adaptation of the PBS. Female sex, higher impulsivity, and higher psychopathology were associated with PB.