bluuebunny/crossref_metadata_2025_split huggingface dataset:
Beyond the Cell Cycle: Enhancing the Immune Surveillance of Tumors Via CDK4/6 Inhibition
Authors: Chaikovsky Andrea C. , Sage Julien 
Published: June 2018

Abstract
Inhibitors of the cyclin-dependent kinases 4 and 6 (CDK4/6) were originally designed to block proliferation and cell cycle progression of cancer cells in which the activity of these kinases is dysregulated. CDK4/6 inhibitors have already been FDA approved for the treatment of estrogen receptor (ER)-positive breast cancer and are being tested in numerous other cancer types. However, several recent studies have identified novel effects of CDK4/6 inhibitors on tumor growth, most notably an indirect effect resulting from the activation of immune surveillance. This Perspective discusses these recent observations, including the effects that CDK4/6 inhibitors may have on immune cells themselves. It is likely that CDK4/6 inhibitors will have a broader impact than their expected induction of cell cycle arrest in the treatment of human cancers. Mol Cancer Res; 16(10); 1454–7. ©2018 AACR.
Intersectionality and Marxism: A Critical Historiography
Authors: Bohrer Ashley 
Published: June 2018

AbstractIn recent years, there has been renewed interest in conceptualising the relationship between oppression and capitalism as well as intense debate over the precise nature of this relationship. No doubt spurred on by the financial crisis, it has become increasingly clear that capitalism, both historically and in the twenty-first century, has had particularly devastating effects for women and people of colour. Intersectionality, which emerged in the late twentieth century as a way of addressing the relationship between race, gender, sexuality and class, has submitted orthodox Marxism to critique for its inattention to the complex dynamics of various social locations; in turn Marxist thinkers in the twenty-first century have engaged with intersectionality, calling attention to the impoverished notion of class and capitalism on which it relies. As intersectionality constitutes perhaps the most common way that contemporary activists and theorists on the left conceive of identity politics, an analysis of intersectionality’s relationship to Marxism is absolutely crucial for historical materialists to understand and consider. This paper looks at the history of intersectionality’s and Marxism’s critiques of one another in order to ground a synthesis of the two frameworks. It argues that in the twenty-first century, we need a robust, Marxist analysis of capitalism, and that the only robust account of capitalism is one articulated intersectionally, one which treats class, race, gender and sexuality as fundamental to capitalist accumulation.
New Findings and Discoveries in the 1507/8 Rome Edition of Ptolemy’s Cosmography
Authors: Peerlings R.H.J. , Laurentius F. , van den Bovenkamp J. 
Published: June 2018

Abstract
In a previous article the watermarks in the text and map pages of the Rome editions of Ptolemy’s Cosmography were described. This article shows how they can be used to reveal hidden knowledge about the development and chronology of the 1507/8 Rome edition of Ptolemy’s Cosmography. It also discusses the discovery of new states of three maps and the appearance of the Ruysch world map in these editions. Atlases in several institutes and libraries in Europe were studied firsthand, whereas information and photographs of atlases in libraries in the United States were collected by e-mail correspondence and internet downloads.
Cicada fossils (Cicadoidea: Tettigarctidae and Cicadidae) with a review of the named fossilised Cicadidae
Authors: MOULDS M. S. 
Published: June 2018

The Cicadoidea comprise two families, the Cicadidae and the Tettigarctidae. This paper evaluates the status and taxonomy of all named Cicadoidea fossils belonging to the Cicadidae. Shcherbakov (2009) has previously revised the Tettigarctidae. Two new genera are described, Camuracicada gen. n. and Paleopsalta gen. n., for Camuracicada aichhorni (Heer, 1853) comb. n. and Paleopsalta ungeri (Heer, 1853) comb. n. A lectotype is designated for Cicada emathion Heer, 1853. Cicada grandiosa Scudder, 1892 is transferred to Hadoa Moulds, 2015 as Hadoa grandiosa comb. n.; Oncotympana lapidescens J. Zhang, 1989 is transferred to Hyalessa China, 1925 as Hyalessa lapidescens comb. n.; Meimuna incasa J. Zhang, Sun & X. Zhang, 1994 and Meimuna miocenica J. Zhang & X. Zhang, 1990 are transferred to Cryptotympana Stål, 1861 as Cryptotympana incasa comb. n. and Cryptotympana miocenica comb. n.; Tibicen sp. aff. japonicus Kato, 1925 is transferred to Auritibicen as Auritibicen sp. aff. japonicus comb. n., and Terpnosia sp. aff. vacua Olivier, 1790 is transferred to Yezoterpnosia Matsumura, 1917 as Yezoterpnosia sp. aff. vacua comb. n. The generic placement of two other fossils is changed to reflect current classification, those species now being Auritibicen bihamatus (Motschulsky, 1861) and Yezoterpnosia nigricosta (Motschulsky, 1866). Two species, Davispia bearcreekensis Cooper, 1941 and Lithocicada perita Cockerell, 1906, are transferred from the subfamily Cicadinae to the Tibicininae, tribe Tibicinini. Cicadatra serresi (Meunier, 1915) is also transferred from the Cicadinae to the Cicadettinae because the Cicadatrini have recently been transferred from the Cicadinae to the Cicadettinae (Marshall et al. 2018). Miocenoprasia grasseti Boulard and Riou, 1999 is transferred from the tribe Prasiini to the Lamotialnini. Tymocicada gorbunovi Becker-Migdisova, 1954 is transferred from the Dundubiini to the Cryptotympanini; Paracicadetta oligocenica Boulard & Nel, 1990 is transferred from the Cicadettini to the Pagiphorini and Minyscapheus dominicanus Poinar et al., 2011 is assigned to the Taphurini. Names of species once considered to belong in Cicadidae, but now excluded, are listed with explanation.
The Rapid Deployments to Wildfires Experiment (RaDFIRE): Observations from the Fire Zone
Authors: Clements Craig B. , Lareau Neil P. , Kingsmill David E. , Bowers Carrie L. , Camacho Chris P. , Bagley Richard , Davis Braniff 
Published: June 2018

AbstractThe Rapid Deployments to Wildfires Experiment (RaDFIRE) was a meteorological field campaign aimed at observing fire–atmosphere interactions during active wildfires. Using a rapidly deployable scanning Doppler lidar, airborne Doppler radar, and a suite of other instruments, the field campaign sampled 21 wildfires from 2013 to 2016 in the western United States. Observations include rotating convective plumes, plume interactions with stable layers and multilayered smoke detrainment, convective plume entrainment processes, smoke-induced density currents, and aircraft in situ observations of developing pyrocumulus. Collectively, these RaDFIRE observations highlight the range of meteorological phenomena associated with wildfires, especially plume dynamics, and will provide a valuable dataset for the modeling community.
From Synoptic to Interdecadal Variability in Southern African Rainfall: Toward a Unified View across Time Scales
Authors: Pohl Benjamin , Dieppois Bastien , Crétat Julien , Lawler Damian , Rouault Mathieu 
Published: June 2018

AbstractDuring the austral summer season (November–February), southern African rainfall, south of 20°S, has been shown to vary over a range of time scales, from synoptic variability (3–7 days, mostly tropical temperate troughs) to interannual variability (2–8 years, reflecting the regional effects of El Niño–Southern Oscillation). There is also evidence for variability at quasi-decadal (8–13 years) and interdecadal (15–28 years) time scales, linked to the interdecadal Pacific oscillation and the Pacific decadal oscillation, respectively. This study aims to provide an overview of these ranges of variability and their influence on regional climate and large-scale atmospheric convection and quantify uncertainties associated with each time scale. We do this by applying k-means clustering onto long-term (1901–2011) daily outgoing longwave radiation anomalies derived from the 56 individual members of the Twentieth Century Reanalysis. Eight large-scale convective regimes are identified. Results show that 1) the seasonal occurrence of the regimes significantly varies at the low-frequency time scales mentioned above; 2) these modulations account for a significant fraction of seasonal rainfall variability over the region; 3) significant associations are found between some of the regimes and the aforementioned modes of climate variability; and 4) associated uncertainties in the regime occurrence and convection anomalies strongly decrease with time, especially the phasing of transient variability. The short-lived synoptic anomalies and the low-frequency anomalies are shown to be approximately additive, but even if they combine their respective influence at both scales, the magnitude of short-lived perturbations remains much larger.
Cognate frequency and assessment of second language lexical knowledge
Authors: Allen David 
Published: June 2018

Aims and objectives/purpose/research questions: Few studies have investigated different-script cognate effects in language assessment contexts. This paper examines the impact of Japanese cognates in a test of English receptive lexical knowledge that is widely used for placement purposes in second language learning contexts. Specifically, the present paper utilizes Japanese cognate frequency to predict test accuracy. 1. Does Japanese cognate frequency influence response accuracy? 2. Does the effect vary by English word frequency and/or lexical proficiency? Design/methodology/approach: Seventy Japanese-English bilinguals completed the multiple-choice English VLT. Data and analysis: Accuracy data for 150 target items and 150 distractor items were analysed separately (10,500 data points in each analysis). Generalized linear mixed-effects models were used with Japanese cognate frequency as the primary predictor and English word frequency and lexical proficiency as covariates. Findings/conclusions: A strong facilitatory cognate frequency effect was observed on both the selection of targets and the rejection of distractor items. This effect was marginally greater for lower proficiency learners. The English word frequency effect was also greater for lower proficiency test takers in the distractor analysis. Originality: The paper is the first to utilize cognate frequency to estimate the cognate effect in different-script languages in language testing. Significance/implications: The study provides robust evidence for the Japanese-English cognate effect in a test of lexical knowledge. This finding is broadly in line with the predictions of the bilingual interactive activation plus model of bilingual lexical processing. In addition, the paper demonstrates that the proportion of Japanese cognates in the test is significantly greater than the proportion of cognates in the language in general, indicating that it may over-estimate Japanese learners’ knowledge of English lexis. Test designers and users are thus recommended to be aware of the impact of cognates when making inferences about language ability based on such tests of lexical knowledge.
Obesity, independent of diet, drives lasting effects on intestinal epithelial stem cell proliferation in mice
Authors: Zhou Weinan , Davis Elizabeth A , Dailey Megan J 
Published: June 2018

The intestinal epithelium plays an essential role in nutrient absorption, hormone release, and barrier function. Maintenance of the epithelium is driven by continuous cell renewal by intestinal epithelial stem cells located in the intestinal crypts. Obesity affects this process and results in changes in the size and function of the tissue. Because both the amount of food intake and the composition of the diet are contributing factors to developing and maintaining obesity, it is necessary to tease apart the separate contributions of obesity versus the type/amount of diet in driving the epithelial changes. C57BL/6J mice were fed a 60% high-fat diet versus a 10% low-fat diet for three months. A pair fed group was included (mice were fed with high-fat diet, but in equal kcal as that eaten by the low-fat diet- fed mice to keep them lean). We investigated the differences in (1) crypt-villus morphology in vivo, (2) the number and function of differentiated epithelial cell types in vivo, and (3) lasting effects on intestinal epithelial stem cell proliferation and growth in vitro. We found that high-fat diet-induced obesity, independent of the high-fat diet, increased crypt depth, villus height, the number of intestinal epithelial stem cells and goblet cells in vivo, and enhanced the size of the enterospheres developed from isolated IESCs in vitro. In addition, there is an interaction of obesity, type of diet, and availability of the diet (pair fed versus ad libitum) on protein and mRNA expression of alkaline phosphatase (an enzyme of enterocytes). These results suggest that high-fat diet-induced obesity, independent of the high-fat diet, induces lasting effects on intestinal epithelial stem cell proliferation, and drives the differentiation into goblet cells, but an interaction of obesity and diet drives alterations in the function of the enterocytes.Impact statementThis study investigates whether obesity or the type/amount of diet differentially alters the proliferation, differentiation, growth, and function of the intestinal epithelial tissue. Although diet-induced obesity is known to alter the growth and function of the epithelium in vivo and cause lasting effects in intestinal epithelial stem cells (IESCs) in vitro, we are the first to tease apart the separate contributions of obesity versus the type/amount of diet in these processes. We found that high-fat diet (HFD)-induced obesity, independent of the HFD, drives lasting effects on IESC proliferation and differentiation into goblet cells, which may contribute to the growth of the epithelium. In addition, there is an interaction of obesity, type of diet, and availability of the diet (PF versus ad libitum) on the function of enterocytes. Identification of the factors driving the epithelial changes may provide new therapeutic strategies to control altered tissue growth and function associated with obesity.
Subchondral Bone and the Osteochondral Unit: Basic Science and Clinical Implications in Sports Medicine
Authors: Saltzman Bryan M. , Riboh Jonathan C. 
Published: June 2018

Context: Articular cartilage injuries and early osteoarthritis are among the most common conditions seen by sports medicine physicians. Nonetheless, treatment options for articular degeneration are limited once the osteoarthritic cascade has started. Intense research is focused on the use of biologics, cartilage regeneration, and transplantation to help maintain and improve cartilage health. An underappreciated component of joint health is the subchondral bone. Evidence Acquisition: A comprehensive, nonsystematic review of the published literature was completed via a PubMed/MEDLINE search of the keywords “subchondral” AND “bone” from database inception through December 1, 2016. Study Design: Clinical review. Level of Evidence: Level 4. Methods: Articles collected via the database search were assessed for the association of bone marrow lesions and osteoarthritis, cartilage regeneration, and ligamentous and meniscal injury; the clinical disorder known as painful bone marrow edema syndrome; and the subchondral bone as a target for medical and surgical intervention. Results: A complex interplay exists between the articular cartilage of the knee and its underlying subchondral bone. The role of subchondral bone in the knee is intimately related to the outcomes from cartilage restoration procedures, ligamentous injury, meniscal pathology, and osteoarthritis. However, subchondral bone is often neglected when it should be viewed as a critical element of the osteochondral unit and a key player in joint health. Conclusion: Continued explorations into the intricacies of subchondral bone marrow abnormalities and implications for the advent of procedures such as subchondroplasty will inform further research efforts on how interventions aimed at the subchondral bone may provide durable options for knee joint preservation.
The Use and Abuse of Human Growth Hormone in Sports
Authors: Siebert David M. , Rao Ashwin L. 
Published: June 2018

Context: Recombinant human growth hormone (rHGH) has become a target of abuse in the sporting world. Conversely, sports medicine clinicians may encounter athletes using rHGH to achieve normalcy in the context of growth hormone (GH) deficiency. Evidence Acquisition: Medline and PubMed databases were queried using the following keywords: GH, GH physiology, GH deficiency, acromegaly, GH athlete, GH sports, GH athletic performance, and GH deficiency concussion. Articles focusing on GH physiology, deficiency, excess, and its effects in both deficient and healthy patients were included. Study Design: Clinical review. Level of Evidence: Level 3. Results: GH is a naturally occurring hormone with important roles in human physiology. Patients with GH deficiency (GHD) present variably, and GHD has numerous etiologies. rHGH treatment has substantial therapeutic benefits for patients with GHD. The benefits of rHGH treatment in otherwise-healthy adults are uncertain. GH excess may cause health problems such as acromegaly. Professional, collegiate, and international sports leagues and associations have banned rHGH use to maintain athlete health, safety, and fair play. Athletes misusing GH may face prolonged suspensions from competition. Implementing GH abuse testing is challenging, but new methods, such as the biomarker testing procedure, are being finalized. Conclusion: rHGH is not only an important therapeutic agent for GH-deficient patients but also a target of abuse in competitive athletics. Its benefits in a healthy, adult population are uncertain. A safe exercise and competition plan, developed with a physician knowledgeable of GH use, physiology, and abuse potential, should be of benefit to a longitudinal clinician-patient relationship.
A Prospective Look at the Link Between Frailty and Shoulder Function in Asymptomatic Elderly Individuals
Authors: Kinnucan Elspeth , Molcjan Matthew T. , Wright David M. , Switzer Julie A. 
Published: June 2018

Introduction: The relationship between shoulder function and overall function in the elderly patients is not well understood. It is hypothesized that there is an increased tolerance of shoulder dysfunction in this population. The purpose of our study was to investigate and better understand the relationship between shoulder function, general musculoskeletal health, and frailty in the elderly patients. Materials and Methods: The dominant shoulders of 75 individuals aged ≥65 years without known dominant shoulder pathology were assessed. Demographic data were collected. Functional evaluation was conducted by administering the Constant, American Shoulder and Elbow Surgeons (ASES), and the Short Musculoskeletal Function Assessment (SMFA) questionnaires. Shoulder range of motion and strength were measured and the Fried frailty phenotype was calculated. Mean age of the patients was 73.6 years. Sixty-seven percent of the patients were female. Mean body mass index was 31.2 kg/m2. Results: Twenty-eight percent of the patients reported the use of an assistive device for ambulation. As frailty increased among the 3 Fried frailty phenotypes (robust, prefrail, and frail), patients had statistically significant lower mean Constant scores ( P < .0001), ASES scores ( P < .0001), higher overall SMFA scores ( P < .0001), and an increase in the use of assistive device for ambulation. Individuals who reported the use of an assistive device for ambulation had lower Constant and ASES scores ( P < .0001 and P = .045, respectively) and higher overall SMFA scores ( P < .0001). There was no evidence of correlation between body mass index and any of the other measures. Conclusions: Frailty and the use of an assistive device for ambulation correlate with poor shoulder function in patients who do not register shoulder complaints and have no known shoulder pathology. Level of Evidence: Level IV, Prognostic.
Knee Joint Kinematics and Kinetics During Walking and Running After Surgical Achilles Tendon Repair
Authors: Jandacka Daniel , Plesek Jan , Skypala Jiri , Uchytil Jaroslav , Silvernail Julia Freedman , Hamill Joseph 
Published: June 2018

Background: Despite the increasing incidence of Achilles tendon (AT) ruptures, there is a lack of information on the possible risks associated with regular running and walking for exercise after an injury. There are some known kinematic gait changes after an AT rupture, especially at the knee. However, it is not clear whether runners with AT ruptures may be at risk for secondary knee injuries during shod or barefoot running/walking. Purpose/Hypothesis: The purpose of this study was to compare the kinematics and kinetics of barefoot walking and barefoot and shod running between athletes with a history of AT ruptures and a healthy control group. We hypothesized that there would be increased knee joint loads in the affected limb of the AT rupture group, especially during shod running. Study Design: Controlled laboratory study. Methods: Ten patients who had undergone surgical treatment of a unilateral acute AT rupture (6.1 ± 3.7 years postoperatively ) and 10 control participants were matched according to age, sex, physical activity, weight, height, and footfall type. The kinematics and kinetics of barefoot walking and barefoot and shod running were recorded using a high-speed motion capture system synchronized with force platforms. Results: The main outcome measures were lower extremity joint angles and moments during the stance phase of walking and running. After AT repair, athletes had increased internal knee abduction moments during shod and barefoot running compared with the healthy control group ( P < .05, η2 > 0.14). There were no significant differences in kinematics and kinetics during walking between the AT rupture and healthy control groups ( P ≥ .05). Conclusion: After an AT rupture, athletes had increased internal knee abduction moments during running compared with the healthy control group. Clinical Relevance: The increased abduction loads on the knee in patients with an AT rupture could lead to further running-related injuries. However, barefoot walking may be used as a proprioceptive exercise without an increased risk of overuse injuries in these patients.
Venous thromboembolism in patients with B-cell non-Hodgkin lymphoma treated with lenalidomide: a systematic review and meta-analysis
Authors: Yamshon Samuel , Christos Paul J. , Demetres Michelle , Hammad Hoda , Leonard John P. , Ruan Jia 
Published: June 2018

Key Points
Lenalidomide is associated with increased venous thrombosis in patients with B-cell NHL, similar to multiple myeloma.