bluuebunny/crossref_metadata_2025_split huggingface dataset:
INDONESIAN STUDENT TEACHERS’ CRITICAL THINKING SKILLS IN TEXT ANALYSIS WITH CDA APPROACH
Authors: Ratnadewi Dwijani , Yunianti Sofi 
Published: May 2019

Purpose of Study: The present study investigated the impact of critical discourse analysis (CDA) on Indonesian students teachers’ critical thinking skills in their final projects.
Methodology: The study analyzed four final projects of student teachers text analysis. It was a qualitative meta-study applying four stages of Brengtsson'scontent analysis. These student teachers analyzed the world leaders’ political speeches and lawyers’ arguments in court using the CDA approach.
Results: The result of the analysis indicated that 58.3% of the students got the Proficient Level achievement, spreading from the critical skills of communication, analysis (interpretation) and synthesis.
Implications/Applications: The result illustrates that text analysis with CDA devices positively influenced the student teachers’ critical thinking skills. Meanwhile, 75% of them were at low achievement, at the Emergent level, for Reflection (Self-regulating) skills, due to the fact that these students were not accustomed to observing their own analysis.
COMPARISON OF PROCESSES CONSTRUCT CONCEPT OF SOLO THEORY AND APOS THEORY IN MATHEMATICS LEARNING
Authors: Hidayatullah Achmad 
Published: May 2019

Purpose of Study: To provide a deep understanding of learning of mathematics, it is necessary to make efforts to realize the conditions of students doing the construction of their understanding. There are many theories that describe thinking in constructing concepts in mathematics. By constructing their understanding, the students can be called doing meaningful learning as mentioned by Ausubel.
Methodology: This research used the comparative process of construct understanding of mathematics with SOLO and APOS theory. SOLO theory (Structure of the Observed Learning Outcome) has five parts namely pre-structural, uni-structural, multi-structural, relational, and extended abstract. While the theory of APOS (Action, Process, object, and Schema). The method used in this research is the study literature from various sources.
Results: This research found the differences construct of the concept in mathematics by using both theories.
Implications/Applications: The SOLO Taxonomic Theory and APOS Theory about its use in constructing mathematical concepts. This means to achieve an individual process needs to do the action repeatedly.
Ethical issues in the early works of accounting
Authors: Garstka Małgorzata 
Published: May 2019

Accountants in Poland have recently had the opportunity to celebrate the 20th anniversary of the introduction of the Accounting Act. The act was passed by the Polish Parliament in 1994. 500 years earlier, a treaty on double-entry accounting system was published by Pacioli. The publishing of Tractatus XI. Particularis de computis et scripturis was a momentous event marking the beginning of a new field of economics. Double-entry accounting was in use since Cotrugli introduce it some thirty years before Pacioli published his work.
Recently, in accounting as well as in economics, emphasis has been put on ethics, moral values, and professional attitudes. It is worth considering whether, or to what extent, these were present in the early works of accountancy from 550 years ago and how accountants approached these matters at the beginning of the written history of accounting.
This article presents the main ideas included in the guidelines set by Pacioli and Cotrugli regarding double-entry systems and investigates if ethical guidelines were present there. It turns out that the author of an essential work in the history of accounting, as well as his predecessor, devoted much attention to the moral attitude of the merchant, their appropriate behaviour, their attitude towards customers, and their colleagues and competitors.
Electrocautery Damage Can Reduce Implant Fatigue Strength
Authors: Sonntag Robert , Gibmeier Jens , Pulvermacher Samuel , Mueller Ulrike , Eckert Johannes , Braun Steffen , Reichkendler Markus , Kretzer J. Philippe 
Published: May 2019

Background:
The risk of femoral stem fracture after total hip replacement is low and can often be associated with a specific implant system or other factors that may reduce the fatigue strength. Additionally, damage to a metal component during revision surgery by an electrocautery device may further affect the fatigue behavior.

Methods:
Two clinical cases of stem failure after revision of fractured ceramic components are presented; the retrieved components were analyzed for the cause of failure. In vitro cyclic load-to-failure testing of titanium alloy femoral stems after electrocautery application at 2 different locations (at the base and about midway on the femoral neck) was performed using a stepwise increase in load until implant fracture occurred. In addition, a detailed characterization of the local material structure around the electrocautery marks was performed.

Results:
Superficial discoloration and melting marks were found on the retrieved components, including at the location of crack initiation in the anterolateral region, which may have reduced the fatigue strength of the material. In addition, elemental analysis indicated material transfer from the electrocautery tip. Damage to the surface by the electrocautery device significantly reduced the in vitro load to failure by up to 47% compared with that of undamaged femoral neck specimens. Material analysis revealed a relevant modification in microstructure, with an extension of approximately 2.7 mm and a depth of 550 µm, which could be divided in 3 structural zones.

Conclusions:
Intraoperative electrocautery device contact with the implant during surgical revision of a total hip replacement cannot always be avoided. However, on the basis of our findings, the risk of implant failure is increased due to a change in microstructure and a potential reduction of the implant’s fatigue strength. Surgeons and manufacturers of electrocautery devices should be aware of this concern.

Clinical Relevance:
During revision surgery, contact between an electrocautery device and the femoral component should be avoided to reduce the chance of subsequent femoral neck fracture.
Risk Factors for Delayed Presentation Among Patients with Musculoskeletal Injuries in Malawi
Authors: Agarwal-Harding Kiran J. , Chokotho Linda C. , Mkandawire Nyengo C. , Martin Claude , Losina Elena , Katz Jeffrey N. 
Published: May 2019

Background:
The burden of injuries is high in low-income and middle-income countries such as Malawi, where access to musculoskeletal trauma care is limited. Delayed treatment can worsen trauma-related disability. Understanding risk factors for delayed hospital presentation will assist in guiding trauma system development.

Methods:
We examined the records of 1,380 pediatric and adult patients with fractures who presented to the orthopaedic clinics of 2 urban referral hospitals and 2 rural district hospitals in Malawi. We used multivariate Poisson regression to evaluate the association between presentation to a hospital ≥2 days after the injury (delayed presentation) and 11 covariates: age, sex, education level, occupation, season of injury, day of injury, injury mechanism, injury type or extremity of injury, referral status, hospital of presentation, and estimated travel time.

Results:
Twenty-eight percent of pediatric patients and 34% of adult patients presented late. In the pediatric cohort, fall (relative risk [RR], 1.40 [95% confidence interval (CI), 1.02 to 1.93]), sports injuries (RR, 1.65 [95% CI, 1.09 to 2.49]), tibial or fibular injuries (RR, 1.36 [95% CI, 1.05 to 1.77]), injury over the weekend (RR, 2.30 [95% CI, 1.88 to 2.80]), estimated travel time of ≥20 minutes (RR, 1.45 [95% CI, 1.16 to 1.81]), referral from another facility (RR, 1.46 [95% CI, 1.05 to 2.02]), and presentation to Kamuzu Central Hospital, Mangochi District Hospital, or Nkhata Bay District Hospital (RR, 1.34 [95% CI, 1.07 to 1.69]) independently increased the risk of delayed presentation. In the adult cohort, fall (RR, 1.85 [95% CI, 1.38 to 2.46]), injury over the weekend (RR, 1.80 [95% CI, 1.38 to 2.36]), estimated travel time ≥20 minutes (RR, 1.36 [95% CI, 1.03 to 1.80]), and presentation to Kamuzu Central Hospital (RR, 1.74 [95% CI, 1.30 to 2.33]) independently increased the risk of delayed presentation.

Conclusions:
Delayed presentation to the hospital after a musculoskeletal injury is common in Malawi. Interventions are needed to improve access to musculoskeletal trauma care, especially for pediatric patients with tibial or fibular injuries, all patients after falls, patients injured over the weekend, and patients living far from health facilities.
International Expert Consensus on a Cell Therapy Communication Tool: DOSES
Authors: Murray Iain R. , Chahla Jorge , Safran Marc R. , Krych Aaron J. , Saris Daniel B.F. , Caplan Arnold I. , LaPrade Robert F. ,   on behalf of the Cell Therapies Communication Expert Group
Published: May 2019

Background:
The lack of a standardized system for describing cell therapies acts as a barrier to advancement in clinical and basic research and practice. The aim of this study was to establish an international expert consensus on strategies to improve standardization and transparency when describing cell therapies. The secondary aim was to develop a consensus among experts on the contents of a standardized tool for describing cell therapies.

Methods:
The need for expert consensus on strategies to improve cell therapy communication was confirmed at the American Academy of Orthopaedic Surgeons/National Institutes of Health Optimizing Clinical Use of Biologics Symposium in 2018. A working group of 6 experts convened an international consensus process involving clinicians and basic scientists using validated Delphi methodology. This iterative process was used to define statements on communication of cell therapies and develop a standardized tool for describing cell therapies.

Results:
Thirty-four experts completed 3 rounds survey with use of the Delphi process. After 3 rounds, 27 statements relating to existing nomenclature, solutions to improve communication, ideal characteristics of a framework, mandatory elements of a new framework, and future work to facilitate application reached consensus with >80% agreement and <5% disagreement. Consensus was reached on the contents of a tool for improving standardization and transparency when describing cell therapies. This tool, dubbed “DOSES,” is based on the reporting of 5 core items: donor (i.e., autologous, allogeneic, xenogeneic), origin of tissue, separation from other cell types/preparation method, exhibited cell characteristics associated with behavior, and the site of delivery.

Conclusions:
This study has established expert consensus on the communication of cell therapies. The DOSES tool has been developed to improve standardization and transparency in describing cell therapies.

Clinical Relevance:
The DOSES tool for describing cell therapies can be utilized by researchers, clinicians, regulators, and industry professionals to improve standardization and transparency when describing cell therapies. The use of this tool may allow clinicians and patients to better understand the characteristics of current and future cell preparations.
An Effort to Improve Students’ Activeness at Structure Class Using Slido App
Authors: Muthmainnah Nur 
Published: May 2019

This research was conducted to improve students’ activeness at structure class by sharing their idea, comment, questions and structure mastery. This research applied slido.com application as the media to teach. It was a classroom action research which had been conducted in two cycles. The subjects of this research were the third semester students of English Education Department of IAIN Salatiga. The writer took one of 3 classes as the sample of the research randomly. The researcher observed the improvement of students’ activeness at structure class by collecting the data through observation and measurement technique. The data were in the form of observation checklist and field notes, documentation, and students’ task. The data which were collected were analyzed to know the description of the class activity and the learning progress. After the cycles conducted, it resulted that there ware improvement in students’ activeness in delivering questions, giving comments, and doing simple task. The description of result was also proven with the students’ mean score improved from 51 in their pre-test into 67 in the second cycle. It can be drawn a conclusion that there is an improvement in students’ activeness in the structure class taught using slido application.
Reducing provider workload while preserving patient safety via a 2-way texting intervention in Zimbabwe’s voluntary medical male circumcision program: study protocol for an un-blinded, prospective, non-inferiority, randomized controlled trial
Authors: Feldacker Caryl , Murenje Vernon , Barnhart Scott , Xaba Sinokuthemba , Makunike-Chikwinya Batsirai , Holeman Isaac , Tshimanga Mufuta 
Published: May 2019

Abstract
Background: Surgical male circumcision (MC) safely reduces risk of female-to-male HIV-1 transmission by up to 60%. The average rate of global moderate and severe adverse events (AEs) is 0.8%: 99% of men heal from MC without incident. To reach the 2016 global MC target of 20 million, productivity must double in countries plagued by severe healthcare worker shortages like Zimbabwe. The ZAZIC consortium partners with the Zimbabwe Ministry of Health and Child Care and performed over 120,000 MCs. MC care in Zimbabwe requires in-person, follow-up visits at post-operative days 2,7, and 42. ZAZIC program adverse event rate is 0.4%; therefore, overstretched clinic staff conducted more than 200,000 unnecessary reviews for MC clients without complications.
Methods: Through an un-blinded, prospective, randomized, control trial in two high-volume MC facilities, we will compare two groups of adult MC clients with cell phones randomized 1:1 into two groups: 1) routine care (control group N=361) and 2) clients who receive and respond to a daily text with in-person follow-up only if desired or if a complication is suspected (intervention N=361). If an intervention client responds affirmatively to any automated daily text with a suspected AE, an MC nurse will exchange manual, modifiable, scripted texts with the client to determine symptoms and severity, requesting an in-person visit if desired or warranted. Both arms will complete a study-specific, Day 14, in-person, follow-up review for verification of self-reports (intervention) and comparison (control). Data collection includes extraction of routine client MC records, study-specific database reports, and participant usability surveys. Intent-to-treat (ITT) analysis will explore differences between groups to determine if two-way texting (2wT) can safely reduce MC follow-up visits; estimate the cost savings associated with 2wT over routine MC follow-up; and assess the acceptability and feasibility of 2wT for scale-up.
Discussion: It is expected that this mobile health intervention will be as safe as routine care while providing distinct advantages in efficiency, costs, and reduced healthcare worker burden. The success of this intervention could lead to adaptation and adoption of this intervention at the national level, increasing efficiency of MC scale up, reducing burdens on providers and patients.

Clinical Trial Registration Number

NCT03119337
A large number of cerebral microbleeds in CADASIL patients presenting with recurrent seizures: A case report
Authors: Anamnart Chumpol , Songsaeng Dittapong , Chanprasert Sirisak 
Published: May 2019

Abstract
Background: Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a hereditary arteriopathy associated with the NOTCH3 gene. Clinical manifestations include strokes, transient ischaemic events, psychiatric disturbances, dementia, and migraines. We report a case of a Thai man with a severe CADASIL phenotype who presented with recurrent seizures and acute ischaemic stroke and classic vascular risk factors.
Case presentation: A 50-year-old man with a history of mood disorder and progressive cognitive decline for 20 years as well as well-controlled diabetes mellitus and hypertension presented with recurrent generalized seizures and acute right-sided weakness. An MRI of the brain showed acute infarction of the left pons, a large number of cerebral microbleeds throughout the brain and white matter abnormalities without classic anterior temporal lobe lesions. Molecular genetic testing identified a homozygous pathologic variant, c.1672C>T (p. Arg558Cys), in the NOTCH3 gene. The diagnosis of CADASIL was confirmed. His clinical symptoms deteriorated, and he died of tracheobronchitis with secretion obstruction.
Conclusion: This case raises awareness of an uncommon cause of acute ischaemic stroke in patients with classic vascular risk factors and emphasizes the need for a complete evaluation in cases with unexpected clinical presentation or unexpected diagnostic study results.
Food‐Grade Maize Composition, Evaluation, and Genetics for Masa‐Based Products
Authors: Holmes Mark , Renk Jonathan S. , Coaldrake Peter , Kalambur Sathya , Schmitz Chuck , Anderson Nickolas , Gusmini Gabe , Annor George , Hirsch Candice N. 
Published: May 2019

ABSTRACTMaize (Zea mays L.) masa (dough or flour that is soaked and cooked in an alkaline solution in the nixtamlization process) based products have been consumed by humans worldwide for thousands of years. Still, there is not a comprehensive understanding of the chemical and physical properties of maize that contribute to masa quality. Starches and proteins affect the alkaline processing of maize but are seldom discussed in a holistic way to understand their individual and combined effects on masa production, particularly in the context of the entire food system from breeding to evaluation to product development and production. In this review, the food‐grade maize production chain is described including current breeding efforts and grain evaluation methods. The compositions of starches and prolamin proteins are also discussed relative to their effect on masa properties. Understanding the interactions of grain endosperm components and final product quality of maize masa‐based products will allow for more efficient breeding and food processing operations in the future.
Temporal Variation in Antibiotic Resistance of Acinetobacter baumannii in a Teaching Hospital in Tunisia: Correlation with Antimicrobial Consumption
Authors: Nadia Jaidane , Wejdene Mansour , Remy A. Bonnin , Meriam Ghardallou , Cherifa Chaouch , Rachida Golli , Nesrine Kalboussi , Noureddine Boujaafar , Olfa Bouallegue , Thierry Naas 
Published: May 2019

Background:
To investigate the potential correlation between the rates of antimicrobial drug consumption and the prevalence of antimicrobial resistance among clinical Acinetobacter baumannii recovered in a tertiary care hospital in Tunisia.

Methods:
The microbiological and epidemiological profiles of A. baumannii infections at the Hospital Sahloul, Sousse, were investigated between 2001 to 2004 and 2012 to 2015 along with the consumption record of broad-spectrum antibiotics.

Results:
Our data showed that extensively drug-resistant A. baumannii (XDRAb) isolates increased from 11.2% to 30.5% between 2012 and 2015 and disseminated endemically for a long time. Furthermore, we evidenced a drastic increase of carbapenem-resistant A. baumannii isolates from 29.5% in 2001 up to 88.6% in 2015 (612/691). This rise could be paralleled with a significant increase in antibiotic consumption over the last 15 years, especially with the sharp increase in the annual consumption of imipenem (r = 0.816 and p <103). A noteworthy correlation between carbapenem use and resistance rate (r = 0.778, p<0.001) was evidenced.

Conclusion:
Feedback of these data to clinicians and decision-makers in the local setting was crucial to promote the rational use of antimicrobials and to raise awareness to strictly implement hygiene measures to limit the spread of these XDRAb isolates, to prevent colonization and subsequent infection.
Baseline Characteristics of Patients with Ankylosing Spondylitis and Psoriatic Arthritis Treated with Secukinumab in the Real-World Setting: AQUILA, a Non-Interventional Study
Authors: Kiltz Uta , Legeler Carolin , Maier-Peuschel Monika , Mann Christian , Tony Hans-Peter 
Published: May 2019

Objective:
AQUILA is an ongoing, multicenter, prospective, Non-Interventional Study (NIS) with secukinumab, designed to evaluate real-world evidence for different aspects of treatment in patients with Ankylosing Spondylitis (AS) and psoriatic arthritis (PsA) in Germany. Here we report the study design and baseline characteristics including comorbidities and prior medication of patients as well as insights into medical care in Germany.

Methods:
Patients (age ≥18 years) with active AS or PsA, who were under secukinumab treatment or just about initiating secukinumab therapy based on medical therapeutic need,
are
enrolled. Each patient
is
observed for 52 weeks.

Results:
A total of 572 patients (AS, n = 187; PsA, n = 385) have been recruited in this ongoing study. Mean age, weight, and BMI were similar between the subgroups. About 66.4% of patients had previously received biologics other than secukinumab. Depression was the most common comorbidity (AS, 9.1%; PsA, 15.6%). Plaque psoriasis was also frequently reported (AS, 9.6%; PsA, 62.3%).

Conclusion:
The Non-Interventional Study (NIS) baseline characteristics indicate that the demographics were similar to populations of previous secukinumab trials of AS and PsA patients except
to
comorbidities and exposure to biologics. A majority of the patients who received secukinumab in this setting had previously received biologics. Comorbidities relating to obesity and cardiovascular disease were particularly evident in PsA patients whereas the elevated depression prevalence was equally distributed.