bluuebunny/crossref_metadata_2025_split huggingface dataset:
ROLE OF IMMUNOHISTOCHEMICAL EXPRESSION OF D2-40 MARKER IN HIGH-GRADE DYSPLASIA, MICROINVASIVE AND FRANKLY INVASIVE ORAL SQUAMOUS CELL CARCINOMA
Authors: Rehan Syeda Areeba , Rashid Wajeeha , Rahat Manahil 
Published: November 2024

Background: Oral squamous cell carcinoma (OSCC) is a prevalent malignancy that develops through a series of stages, ranging from high-grade dysplasia (HGD), microinvasive OSCC (MiOSCC) to frankly invasive OSCC. However, sometimes it is difficult to differentiate HGD from MiOSCC and invasive OSCC in histopathological morphology on routine staining. The aim of the study was to assess the expression patterns of D2-40 in these distinct stages of oral carcinogenesis, providing insights into its potential role as a biomarker for disease progression. Methods: This cross-sectional study was carried out in the Department of Histopathology, Armed Forces Institute of Pathology, Rawalpindi, Pakistan, from 1st Dec 2023 to 5th Feb 2024. It involved the application of a D2-40 immunohistochemical marker on a total of thirty tissue samples, ten patients diagnosed with High-grade dysplasia (HGD), ten with Microinvasive Oral squamous cell carcinoma (OSCC), and ten invasive OSCC cases. SPSS was used for data analysis and a p-value < 0.05 was considered significant. Results: The mean age of patients was 60.47±11.78 years, males were affected more (70%). D2-40 was expressed in different stages of oral carcinogenesis in increasing order as in 40% in HGD (4/10), and 90% in both microinvasive (9/10) and invasive OSCC (9/10) lesions. D2-40 IHC expression was associated with the patient's age and disease. Conclusion: Podoplanin (D2-40) has the potential to be a novel biomarker for the timely identification of microinvasion in early oral epithelial pathologies with diagnostic dilemmas.
Visual Branding of Universitas Negeri Padang Eartquake and Tsunami Disaster Rensponse
Authors: Mutia Sari Dwi , MSI Heldi 
Published: November 2024

Padang is a city prone to earthquakes and tsunamis. Universitas Negeri Padang is one of the universities that focuses on public services. Therefore, it plays an active role in disaster preparedness, including by providing lecture buildings with mitigation shelters. This is done to support the government in reducing casualties due to earthquake and tsunami disasters. This research uses the Research and Development method, which produces visual branding in the form of UNPSIGAP's visual identity based on design principles and logos. So that it can build a positive brand image as an earthquake and tsunami disaster response university.
The new spirit of capitalism and artisan work: professionalization, autonomy and identity in the brewing industry
Authors: Sgorla Andrey Felipe 
Published: November 2024

The craft beer market in Brazil has experienced significant growth over the past decade, reflecting a global trend towards craft brewing as a counterpoint to industrial standardisation and mass production. This comprehensive study explores the professionalization and identity formation within the dynamic craft beer industry, emphasising the essential role of craftsmanship and authenticity. Through qualitative interviews and participant observation, the research highlights how microbrewery owners navigate the complex challenges of the competitive market, balancing passion with precarious working conditions. The study draws on Boltanski and Chiapello's framework of the new spirit of capitalism, examining how brewers' narratives reflect broader cultural and economic shifts. Craft brewers are portrayed as innovative cultural entrepreneurs who priorieise creativity and autonomy, often at the expense of job security and financial stability. The findings suggest that the craft beer market is a site of economic activity and a space for personal expression and identity construction, where passion and practical knowledge are fundamental to building beer entrepreneurship.
Um exame da presença da etnomatemática na Coleção Teláris Essencial Matemática do PNLD 2024/2027: pontos de convergência e de divergência com a cultura do povo Katokinn
Authors: Jesus Neto Aloízio Ferreira de , Santos Claudiene dos 
Published: November 2024

Esta pesquisa foi motivada pelas dificuldades de aprendizagem dos alunos pertencentes ao povo Katokinn, percebidas durante o estágio supervisionado. Na ocasião, foi perceptível que a linguagem utilizada no livro didático não favorecia o aprendizado, pois não fazia conexões com o cotidiano da referida comunidade. Desta forma, o objetivo geral é examinar a coleção do livro Teláris Essencial Matemática PNLD[1] 2024/2027, adotado na escola em questão, e observar os conteúdos que apresentam uma convergência ou uma divergência com a cultura do povo Katokinn. Como objetivos específicos almeja-se demonstrar quais conteúdos relacionados à Etnomatemática estão presentes na coleção examinada, bem como discutir sobre a importância da Etnomatemática presente no livro didático para melhorar o ensino de matemática no cotidiano do povo Katokinn. A presente pesquisa se configura como exploratória de acordo com a profundidade do estudo, com relação à abordagem trata-se de uma pesquisa qualitativa e com referência aos procedimentos trata-se de uma pesquisa bibliográfica. Como resultados, percebeu-se que a presença da etnomatemática nos livros didáticos examinados ainda é pequena, pois pouquíssimos conteúdos são retratados fazendo alusão à esta tendência de ensino.
ئاسۆی گۆرانكاری دیموكراسی لە هەرێمی كوردستان- عێراق ڕاستی و ئارەزوو توێژینەوەیەكی كۆمەڵایەتی شیكارییە
Authors: Mhamad Miran , حمدان  
Published: November 2024

استهدف البحث التعرف على واقع وافاق التحول الديمقراطي في اقليم كردستان العراق، لان الاهتمام بتطبيق الديمقراطية في إقليم كردستان مسألة مهمة للإصلاح السياسي وإيجاد المناخ السلمي للتعبير ، وأبعاد الاحتقان السياسي المتمثل في العنف والتوتر وعدم الاستقرار الذي يعانيه الكثير من المجتمعات المنطقة في الوقت الراهن بسبب الأزمات وتوابعها العديدة.
فضلا عن ذلك ، تتجلى أهمية هذا الموضوع باعتباره متغيرا أصيلا يعكس التفاعل المحوري للحياة السياسية والنظام السياسي الكردي، واثر هذا التفاعل على أداء النظام السياسي وعلى أفاق وإمكانيات تحقيق عملية التحول الديمقراطي، ويعد هذا البحث من البحوث الوصفية واستخدمتا فيها المنهج الاستقرائي والاستنباطي والاستنتاجي لتحليل محاور البحث، وتوصل البحث الى استنتاجات عديدة اهمها:

انطلقت موجة التحول الديمقراطي في إقليم كردستان العراق في وأوائل التسعينات أبان استلام النخبة السياسية الكردية الحكم في اقليم كردستان العراق.
بصورة عامة في الإقليم هناك تطورات مشجعة حول مسالة التحول الديمقراطي والانجازات المـــتحققة مـــن ذلــــك.

تحسين الأوضاع الاقتصادية والاجتماعية إلى درجة بعد من مؤشرات التغير والتطور للتحول المناسب نحو التحول الديمقراطي في الإقليم
علي غياث الدين البامرني النقشبندي ١٩٢٤-٢٠٠٠ نبذة عن حياته ونشاطه الثقافي جريدة هاوکاری (التضامن) انموذجا
Authors: علي منيفة , نعمان نژيار نعمان 
Published: November 2024

الملخص
يعد علي غياث الدين البامرني أحد المثقفين والصحفيين الكورد النشطين ، تأثر بوالده الشيخ غياث الدين شيخ تكية بامرني من الناحية الثقافية والانسانية والاجتماعية والفكرية ولكن باسلوب مختلف عن طريق التصوف فقد اتبع طريق الصحافة والجمعيات والحداثة.
قدم خدمة كبيرة لصحافة ولهجة بهدينان من خلال صفحة منوعات/صفحة من لهجتي (هه‌مه‌ره‌نگ / به‌رپه‌ره‌ك ژ زاراڤێ من) في جريدة هاوكارى(التضامن)، وكانت هذه الصفحة إحدى مراحل بدايات الصحافة البهدينية فقد سبقتها مجلة روناهي والقسم الكردي من جريدة الحقيقة/راستي(الموصلية) .
بدأت الصفحة باشراف وتحرير علي النقشبندي وكانت شيء كبير ومهم لاهل بهدينان لأنه لم يكن هناك في تلك الفترة صحف باللهجة البهدينية و جذبت ادباء و مثقفي المنطقة للكتابة فيها، نشر علي النقشبندي فيها حوالي ٢٥٥ مقالا اغلبها باسماء مستعارة أو بدون اسم بالاضافة الى عمله في تحرير الصفحة والاشراف على مقالات الكتاب الاخرين، واختلفت مقالاته في جريدة هاوكارى ما بين سياسي و ثقافي وتاريخي ولكن الاغلب کانت قصص قصيرة.
Analisis Peningkatan Literasi Siswa Dengan Menggunakan Media Let’S Read Asia Di SDN Pasirayu
Authors: Firmansyah Amelia , Setiana Diana , Fikriyah Fikriyah 
Published: November 2024

Literasi juga merupakan landasan untuk pembelajaran sepanjang hayat dan pengembangan pribadi yang berkelanjutan. Peneliti mengidentifikasi tiga masalah yaitu belum maksimal dan kurangnya siswa dalam literasi membaca siswa, belum menggunakan media digital untuk meningkatkan literasi siswa, belum menemukan solusi untuk menghadapi hambatan dalam meningkatkan literasi siswa. Penelitian ini berfokus pada peningkatan literasi siswa dengan menggunakan media let’s read asia di SDN pasirayu. Tujuan dari penelitian ini untuk mengidentifikasi kemampuan literasi membaca siswa, mengidentifikasi cara guru menggunakan media let’s read asia untuk meningkatkan literasi membaca siswa, mengidentifikasi guru untuk menghadapi hambatan dalam meningkatkan literasi membaca siswa. Penelitian ini termasuk kedalam penelitian kualitatif. Hasil penelitian ini menunjukan bahwa media let’s read asia efektif dalam meningkatkan kemampuan literasi membaca siswa. Meskipun terdapat beberapa faktor hambatan seperti keterbatasan internet ketika menggunakan media let’s read asia. Dan solusi tepat yang dapat mengatasi hambatan adalah bekerja sama dengan pemerintah agar mendapatkan internet yang bagus. Dari pernyataan tersebut dapat disimpulkan bahwa menggunakan media let’s read asia sangat efektif untuk meningkatlkan literasi membaca siswa di SDN Pasirayu.
Improving access to gene therapies: a holistic view of current challenges and future policy solutions in the United States
Authors: Wagner Tyler D , Buelt Lisabeth , Westrich Kimberly , Campbell Jonathan D 
Published: November 2024

Gene therapies hold the promise of delivering groundbreaking improvements in health outcomes for previously intractable diseases. These therapies possess unique characteristics that differ from traditional small molecule or biologic treatments, posing new challenges for healthcare stakeholders. While previous analyses have predominantly focused on the payment challenges associated with emerging gene therapies, a more holistic examination reveals numerous obstacles that currently hinder optimal patient access. In the United States (US), these include production and distribution issues, logistical and treatment administration challenges and coverage and reimbursement limitations imposed by US healthcare payers. Several opportunities exist to address these challenges and improve patient access, including the use of appropriate value assessment methods, the development of innovative payment solutions, the removal of inappropriate access barriers imposed by payers and improving education and awareness regarding treatment availability, benefits and risks. Moving forward, we must collectively strive for comprehensive policy and market solutions that are sensitive to the uniqueness of gene therapies to ensure their full potential is realized and these treatments are made available to those in need.
Design and Operation of Hydropower Plants with BIM Digital Technologies
Authors: Rodolfo Côrtes Pires João , Sergio Franco Barbosa Paulo , Nogueira Resende Pedro , Regina Mizrahy Cuperschmid Ana 
Published: November 2024

The intricate nature of hydropower plant design and operation, coupled with multiple domains of expertise, regulations, and numerous stakeholders, presents prospects for enhancing quality and cutting overall costs through cooperation and integration. The practical application of Virtual Design and Construction (VDC) and Building Information Modeling (BIM) in the design and O&M planning stages can significantly contribute to these goals. This chapter’s material is partially based on firsthand observations made while working on an R&D project funded by a consortium of hydropower-producing enterprises. To enhance the quality of the project life cycle as a whole, we plan to draw attention to particular BIM modeling concerns that ought to be considered while designing hydropower components (such as water intakes and powerhouses). The case study is based on the BIM modeling of three built plants to construct a digital twin. These HPPs are in South Brazil: (1) Barra Grande hydropower plant, with an installed capacity of 690 MW; (2) Foz do Chapecó hydropower plant, with an installed capacity of 855 MW; (3) 14 de Julho hydropower plant, with an installed capacity of 100 MW.
Frontal Lobe Electrical Stimulation Enhances Connectivity in Alzheimer’s Disease Networks: Evidence from rs-fMRI
Authors: Salkhori Fatemeh , Taghvatalab Samaneh , Abouelsoud Mohammed , Barzegar Mojtaba , Mema Fjona , Dodin Salma , Guessoum Abderraouf , Mishelevich David , Kashou Nasser 
Published: November 2024

This paper presents a comprehensive investigation into the effects of amplitude-modulated transcranial pulsed current stimulation (am-tPCS) on individuals diagnosed with Alzheimer’s disease (AD). The application of am-tPCS is a non-invasive brain stimulation technique that may have the potential to improve AD symptoms. Five AD patients underwent a 12-week intervention involving daily am-tPCS sessions lasting 20 minutes each. Electrodes were placed on the supra-orbital region of the frontal lobe. Baseline and 12-week assessments included resting-state functional MRI scans. Analyses encompassed a range of functional connectivity metrics, notably integrated local correlation (ILC), interhemispheric coherence (IHC), multivariate correlation (MCOR), and assessments of large-scale network connectivity. Following the 12-week am-tPCS intervention, AD patients exhibited significant alterations in connectivity across various domains. Notably, connections within the default mode and salience networks showed considerable enhancement following treatment. Daily am-tPCS stimulation boosted local and global functional connectivity in AD patients in areas implicated in Alzheimer’s disease pathology. Strengthening residual pathways critical for memory, executive functions, and emotional regulation may underlie cognitive improvements. Further research with larger samples is warranted to replicate findings and correlate imaging changes with behavioral outcomes. Overall, am-tPCS shows promise as a therapeutic modality for enhancing brain connectivity in AD.
Tasawuf Nusantara: Wuṣūl Perspektif Mbah Munshorif Dalam Al-Bidayat Majallatun Nihayat
Authors: Al Farisi M. Alan 
Published: November 2024

Abstract
This research is motivated by the oddity of Mbah Munshorif and his book. Mbah Munshorif is not an educated person but has an extraordinary book containing Sufism lessons, one of which explains about wuṣūl to Allah. To find out the figure of Mbah Munshorif and his concept of wuṣūl to Allah, the author then conducted a research with the title "Tasawuf Nusantara: The Concept of Wuṣūl from the Perspective of Mbah Munshorif in the Book of Al-Bidayat Majallatun Nihayat" with a qualitative research method that uses interviews and analysis of Mbah Munshorif's documents. From the research that has been done, it can be seen that Mbah Munshorif is a community leader who has the uniqueness of having many students from various regions, some of whom are educated and educated people, even pesantren caretakers and lecturers. Even though he never received a higher education. In addition, Mbah Munshorif is famous for his various miracles, one of which is folding the earth. Mbah Munshorif has a concept of tasaswuf or wuṣūl which has a tendency to tawakal. Mbah Munshorif said that wuṣūl is solely a gift from Allah. If a person is wuṣūl to Allah, Allah will cover all his shortcomings and defects with His majesty, greatness, glory, and versatility. Thus, the person is overwhelmed by His noble attributes and His supreme will until his ego and all his desires are gone.

Keywords: Mbah Munshorif, Tawakal, Wuṣūl.

Abstrak
Penelitian ini dilatarbelakangi keganjilan Mbah Munshorif dan bukunya. Di mana Mbah Munshorif bukanlah orang terpelajar namun memliki buku yang lauar biasa yang berisikan pelajaran tasawuf yang salah satu isinya menjelaskan mengenai wuṣūl kepada Allah. Untuk mengetahui sosok Mbah Munshorif dan konsep wuṣūl-nya kepada Allah, penulis kemudian melakukan penelitian dengan judul “Tasawuf Nusantara: Konsep Wuṣūl Perspektif Mbah Munshorif dalam kitab Al-Bidayat Majallatun Nihayat” dengan metode penelitian kualitatif yang menggunakan wawancara dan analisis dokemen karya Mbah Munshorif. Dari penenlitian yang telah dilakukan dapat diketahui bahwa Mbah Munshorif merupakan tokoh masyarakat yang mempunyai keunikan memmiliki banyak murid dari berbagai daerah yang sebagainnya adalah orang-orang terpelajar dan terdidik, bahakan pengasuh pesantren dan dosen. Padahal beliau tidak pernah mengenyam pendidikan yang tinggi. Selain itu, Mbah Munshorif terkenal dengan berbagai karamah-nya yang salah satunya adalah melipat bumi. Mbah Munshorif mempunyai konsep tasawuf atau wuṣūl yang mempunyai kecenderungan pada tawakal. Mbah Munshorif mengatakan bahwa wuṣūl merupakan semata-mata anugerah Allah. Baranag siapa yang dikehendaki Allah wuṣūl kepada-Nya, maka Allah akan menutupi segala kekurangan dan kecacatannya dengan keagungan, kebesaran, kemuliaan, dan kesempunaan-Nya. Sehingga orang tersebut diliputi segala sifat-Nya yang mulia dan kehendaknya yang paling kuasa hinga sirnalah egonya dan segala kehendaknya adalah kehendak Allah serta pilihannya adalah pilihan Allah.
Pembuatan Aplikasi Computer Based Test Berbasis Website Menggunakan Algoritma Fisher-Yates Shuffle
Authors: Raviy Bayu Setiaji  , Firza Prima Aditiawan  , Agung Mustika Rizki  
Published: November 2024

This research focuses on the development of a web-based Computer Based Test (CBT) Application for Madrasah Tsanawiyah (MTs) Faqih Hasyim in Sidoarjo, East Java. This application aims to overcome conventional evaluation problems with paper and pen, such as cheating, scoring errors, and data management difficulties. Using web technologies such as HTML, CSS, PHP, and JavaScript, the application integrates the Fisher-Yates Shuffle algorithm to randomize the order of questions, reducing the possibility of cheating during the exam. Equipped with session tokens, exam timing, and result reports, the app improves the overall efficiency of the evaluation process. This study refers to previous research and highlights the importance of adopting technology to simplify assessment and facilitate online data management. The Fisher-Yates Shuffle algorithm, used to generate a unique sequence of questions for each student during the exam, minimizes the risk of cheating. The app implements a staged exam, ensuring students who meet the minimum criteria proceed to the next stage. In addition, the app achieves a degree of randomization of the exam content, eliminating patterns that may affect the exam results. The feasibility testing results show that the app is highly feasible, with a feasibility percentage of 92.4%. This conclusion signifies the app's success in achieving its development goals and making a positive contribution in easing the exam grading process. It is recommended to simplify the interface for senior users, improve the responsiveness of the website display for mobile access, and add a time limitation method in future research.

Keywords: Fisher-Yates Shuffle Algorithm, Computer Base Test, Question Randomization.
Kūrybos socialiniai aspektai
Authors: Kačerauskas Tomas 
Published: November 2024

Straipsnyje nagrinėjami kūrybos socialinės aplinkos, kūrėjo bei kūrybos visuomenės santykio klausimai. Plėtojamos tezės: 1) bet kokia kūryba suponuoja socialumą, tačiau ne atvirkščiai: ne bet kokia socialinė aplinka suponuoja kūrybą; 2) naujos meno krypties pradininkas ir išbaigėjas – du asimetriški socialine prasme poliai: pradininkas asocialus pirmtakų atžvilgiu, bet socialus savo pasekėjų atžvilgiu; išbaigėjas, atvirkščiai, asocialus epigonų ir pamėgdžiotojų atžvilgiu, bet socialus savo pirmtakų atžvilgiu; 3) kuo individas labiau iškilęs virš savo socialinio fono, tuo labiau tikėtina, kad jis – įžymus; 4) iškilumas (iškilimas) didina asocialumo riziką; 5) kūrybos visuomenės ugdymas pastatytas ant meno (su)vartojimo kortos.
Una aproximación integral al origen del champán en el Río Magdalena (Siglos XVI-XIX)
Authors: Nieva Sanz Daniel Miguel 
Published: November 2024

La conexión entre el interior del Nuevo Reino de Granada y los puertos del litoral caribe, así como el vínculo de este con la Corona desde mediados del siglo XVI, fue posible mediante un sistema de navegación sostenido sobre embarcaciones fluviales que cubrieron el curso navegable del río Magdalena. La definición de estos artilugios náuticos, más allá de la denominación asentada, exige la valoración de los aspectos conceptuales, morfológicos y funcionales de estos champanes, que cumplieron un rol estratégico durante al menos tres siglos. De este modo, la presente aplicación de una metodología historiográfica con perspectiva náutica sobre fuentes primarias, manuscritas y editadas, así como un análisis integral, ha permitido mayor precisión en la definición del champan y su protagonismo en una de las vías de comunicación más relevantes de la América hispana a lo largo de la Edad Moderna.
The connection between the interior of the New Kingdom of Granada and the ports of the Caribbean coast, as well as its link with the Crown since the mid-16th century, was possible through a navigation system supported by river boats that covered the navigable course of the Magdalena River. The definition of these nautical gadgets, beyond the established denomination, requires the assessment of the conceptual, morphological and functional aspects of these champanes, which played a strategic role for at least three centuries. In this way, the present application of a historiographical methodology with a nautical perspective on primary, manuscript and edited sources, as well as a comprehensive analysis, has allowed greater precision in the definition of champan and its role in one of the most relevant communication routes of Hispanic America throughout the Modern Age.
Pengaruh Variasi Sudut Kampuh dan Kuat Arus Pengelasan Hasil Las SMAW Baja SS400 untuk Bahan Bejana Tekan terhadap Kekuatan Tarik dan Kekerasan
Authors: Hanan Setia Abadi  , Subagiyo Subagiyo 
Published: November 2024

A pressure vessel is a closed container that stores pressurized liquids or gases. Low-carbon steel is used as a material for pressure vessels that operate at low to moderate temperatures. One of the important aspects of manufacturing pressure vessels is the welding process. The welded area tends to be the weakest point due to exposure to high heat, which can lead to greater residual stress and potentially cause cracking. This study aims to evaluate the effect of variation in ample angle and current strength on mechanical properties, especially tensile strength, and hardness, to determine the optimal amplitude angle and current strength. The research method applied is an experiment by conducting SMAW welding on SS400 steel using E7016 electrodes, with a single V ample angle variation of 55°, 60°, 65°, and strong welding current of 110 A, 120 A, and 130 A, then a tensile test and hardness test are carried out. The results show that the tensile strength of the raw material is 481.2 with a hardness of 191.95 HVN. For the variation of the amputation angle, the highest tensile strength value was recorded at an angle of 55°, which was 567.471 N/mm2 , while the lowest was at an angle of 65°, which was 559.997 N/mm2 . The highest hardness value at a 65° angle reached 328.422 HVN, while the lowest at a 55° angle was 312.878 HVN. In terms of current strength variation, the highest tensile strength is obtained at 130 A which is 568.421 N/mm2 and the lowest at 110 A is 552.339 N/mm2 . The highest hardness value is found at a current strength of 110 A, which is 343.411 HVN, and the lowest at a current strength of 130 A, which is 295.122 HVN. The optimal parameters were found at a yield angle of 55° with a tensile strength of 567.471 N/mm2 and a hardness of 312.8 HVN and a current strength of 130 A with a tensile strength of 568.421 N/mm2 and a hardness of 295.1 HVN.