bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analysis of Sulfate Compounds From Sanguisorbae Radix and Its Major Metabolites in Rats by UPLC‐MS/MS and Molecular Docking
Authors: Wang Qing , Huo Zhipeng , Han Bingjing , Sun Yujing , Lei Lei , Xu Weitong , Song Zhaohui , He Yi 
Published: December 2024

ABSTRACTRationaleSanguisorbae Radix that mainly contains tannins and phenolic compounds has been widely used as a traditional Chinese medicine for treating hemafecia, hemorrhoids metrorrhagia and metrostaxis in clinics. However, there is no report about the sulfate phenolic compounds in Sanguisorbae Radix.MethodsExtraction of Sanguisorbae Radix was separated and purified by polyamide resin and octadecyl silane‐bonded silica, which were analyzed by HPLC‐IT‐TOF/MS. Analysis of rat plasma and urine samples using UPLC‐Q‐TOF/MS. Finally, the newly discovered sulfate esters in Sanguisorbae Radix were investigated by molecular docking to find out the linkage and the possible mechanism to psoriasis.ResultsThe chemical structures of methyl‐3‐O‐methylgallate‐5‐O‐sulfate and methyl‐3‐O‐methylgallate were elucidated by the spectral data of HRESIMS and NMR. In addition, 6 sulfate compounds were rapidly identified in Sanguisorbae Radix for the first time, among which 3 sulfate compounds were new natural products. Sixteen prototypes and 11 metabolites were found in rat plasma and urine samples, including 6 sulfate phenolic compounds, and their metabolic pathways in vivo were inferred. Molecular docking technique was used to validate the binding activity of methyl‐3‐O‐methylgallate‐5‐O‐sulfate to psoriasis‐related target proteins.ConclusionsIn this study, sulfate phenolic compounds with high content in Sanguisorbae Radix and biological samples were isolated and characterized by modern spectroscopic techniques, which may provide a theoretical basis for the study of the pharmacological activity and quality control of Sanguisorbae Radix and development of sulfate drugs with a similar structure.
Histiocyte‐rich ROS1‐rearranged inflammatory myofibroblastic tumour of the trachea: A rare neoplasm presenting with asthma‐like symptoms
Authors: Kwok Chin Tong , Tsang Jason Cheuk Ho , Lam Mary , Ho Sandy Sze Ki , Yuen Chi Sum , Yeung Yiu Cheong 
Published: December 2024

AbstractInflammatory myofibroblastic tumour is a rare tumour. We present an atypical case of Inflammatory myofibroblastic tumour which was trachea in location, histocyte rich and ROS1 rearranged. The patient presented with upper airway obstruction, which was an asthma mimic. The tumour demonstrated rapid recurrence after mechanical coring, which subsequently controlled with radiotherapy.
Synthesis of Aluminum Complexes Based on 2,6‐Bis(2‐hydroxyphenyl)Pyridines: Efficient Initiators for Ring‐Opening Polymerization of Cyclic Esters
Authors: Serova Valeriia A. , Lykov Artem V. , Mankaev Badma N. , Agaeva Milana U. , Lyssenko Konstantin A. , Chernikova Elena V. , Zabalov Maxim V. , Egorov Mikhail P. , Karlov Sergey S. 
Published: December 2024

AbstractThe search for new initiators based on nontoxic metal complexes, allowing for the controlled production of polycaprolactone (PCL) and polylactide (PLA) is an actual task. In the present work, we report the synthesis of aluminum complexes 6a and 6b based on substituted 2,6‐bis(2‐hydroxyphenyl)pyridine pro‐ligands. The compositions and structures of the novel compounds were established by elemental analysis and 1H, 13C, NMR spectroscopy in the solid state by X‐ray diffraction analysis (6a and 6b). All the synthesized aluminum complexes are monomeric. Complexes 6a and 6b (in presence of benzyl alcohol (BnOH)) turned out to be active in the ring opening polymerization (ROP) of ε‐caprolactone (ε‐CL), L‐, rac‐lactide (L‐, rac‐LA) gave PCL and PLA with high molecular weights. The mechanism of the polymerization reaction for compounds С, 6a, and 6b was also investigated using the density functional theory (DFT) method. The substituent effect analyzed in terms of percent buried volume and non‐covalent interactions. The values of calculated Gibbs free activation energies correspond to the trend found experimentally.
Tailoring the Electrode Interface Microenvironment to Stabilize Zn Metal Anode
Authors: Hou Weiping , Gao Yuliang , Huang Shifeng , Tian Penghui , Cao Yanjiao , Han Chenhui , Gu Xiaojun , Wu Limin 
Published: December 2024

AbstractZn metal is the most attractive anode material for aqueous batteries, yet it encounters challenges from dendrites. Here, based on lanthanum trifluoromethanesulfonate (La(OTf)3)‐based electrolyte, the idea of tailoring the electrode interface microenvironment (ion concentration, solid electrolyte interphase (SEI) and electric field) is proposed to stabilize the Zn metal anode. The theoretical and experimental results show that the reconstruction of the electrolyte microstructure by OTf− and the capture of SO42− by La3+ enhance the liquid‐phase mass transfer, which alleviates the ion concentration gradient on the anode surface. Meanwhile, the electrolyte decomposes to form a favorable inorganic‐rich SEI. Importantly, the adsorbed La3+ homogenizes the electric field intensity at the tip of the anode surface. Benefiting from the improved interface microenvironment, the Zn electrodeposition behavior is efficiently regulated, endowing the self‐elimination behavior of the regenerated dendrites. As a proof‐of‐concept, the Zn metal anode shows a highly reversible plating/stripping cycling in both Zn||Cu (7000 cycles) and Zn||Zn cells (3600 h). Also, the NH4V4O10||Zn pouch cell operates stably for over 500 cycles and exhibits a low‐gassing behavior.
Optimizing Electrocatalysis and Domain Effects of Graphene on Li2S Cathodes for High‐Efficient‐Stable Li─S Batteries
Authors: Zhang Junfan , Zhao Bo , Qian Mengmeng , Yu Chuguang , Mao Pengcheng , Xie Jing , Huang Jia‐Qi , Wu Feng , Tan Guoqiang 
Published: December 2024

AbstractReducing the initial activation barrier of Li2S is crucial for enhancing the coulomb efficiency and cycle life of Li─S batteries. Herein two Li2S‐graphene cathode architectures are constructed and investigated the electrocatalytic and domain effects of two graphene on Li2S. Systematic studies reveal an unprecedented relevancy between Li2S activation and graphene electrocatalysis, as well as an intrinsic relationship between Li2S stability and the graphene domain. A dramatically reduced initial activation potential of 2.8 V is achieved via the S─C bonding electrocatalysis of Li2S−graphene structure, much lower than the initial activation potential of 3.68 V triggered by two‐phase electrocatalysis of Li2S/graphene composite. Density functional theory calculations offer mechanism insights into the electrocatalytic effect of S─C bonding on reduced overpotential, and in situ NMR provides solid evidence for the confinement effect of core‐shell structure on enhanced cyclability. Notably, a specially designed Li2S@graphene cathode with core‐shell structure and S─C interactions exhibit both superior electrocatalytic activation and electrochemical reversibility, enabling Li─S battery promising electrochemical properties, including low charge–discharge overpotential, high specific capacity, and excellent cycling performance. More importantly, it demonstrates excellent chemical compatibility within various electrolytes. This study provides valuable theoretical insights for the development of high‐performance Li2S‐graphene cathode materials.
Long‐Range Anion Correlations Mediating Dynamic Anharmonicity and Contributing to Glassy Thermal Conductivity in Well‐Ordered K2Ag4Se3
Authors: Li Fan , Liu Xin , Yang Jiawei , Wang Xin‐Ye , Yang Yi‐Chang , Ma Ni , Chen Ling , Wu Li‐Ming 
Published: December 2024

AbstractHerein an extremely low (0.32‒0.25 Wm−1K−1) and glassy temperature‐dependence (300–600 K) of lattice thermal conductivity (κlat) in a monoclinic K2Ag4Se3 is reported. It is found that the effective carrier delocalization, contributed by the perfect p−d* hybridization paradigm, can efficiently facilitate the spatial transfer of electron cloud perturbations induced by the anisotropic thermal vibrations of Ag4 atoms, thereby favoring long‐range Se‒Se correlations. The localized rattling‐like vibration of Ag4 atoms induce short phonon lifetimes, large scattering phase space, and then a low particle‐like propagation. While the correlated interactions mediated competitive expressions between bubble diagrams and loop diagrams can suppress the generation of wavelike phonons from off‐diagonal coupling. Ultimately, the AgSe3 structural units can enable the dual confinement of both the particle‐like propagation of phonons and wavelike tunneling of coherence. The study highlights that the correlated AgSe3 coordination units can simultaneously target particle‐like and wavelike phonons and then reduce their contribution to the κlat by mediating long‐range transfer of charge polarization. These fundamental advances will advance the design of crystalline materials with tailored thermal properties.
General Expression of Best Equivariant Estimators of Regression Coefficients in Seemingly Unrelated Regression Models
Authors: Matsuura Shun , Kurata Hiroshi 
Published: December 2024

ABSTRACTSeemingly unrelated regression models have been commonly employed as regression models with multiple explanatory variables and multiple response variables having cross‐correlations. This paper discusses equivariant estimation of the regression coefficient vector and derives the best equivariant estimator under a generalized quadratic loss function. The result of this paper is shown to include the results of previous best equivariant estimators under specific loss functions as special cases.
Numerical study on the flexural and shear behavior of steel fiber and high‐strength steel combination in ultra‐high‐performance fiber‐reinforced concrete beams under cyclic loading
Authors: Nasiri Havre , Pourbaba Masoud , Lotfollahi Yaghin Mohammad Ali 
Published: December 2024

AbstractFiber‐reinforced concrete consists of hydraulic cement, water, aggregate, and discrete fibers, making it a composite material. These fibers, available in different shapes, sizes, and materials such as steel, polymer, glass, and natural fibers, are commonly utilized in structural applications. The tensile strength of conventional concrete tends to decrease as micro‐cracks develop rapidly under applied stresses. However, incorporating closely spaced fibers can hinder the progression of micro‐cracks, leading to a substantial improvement in both tensile and flexural strengths of concrete. Furthermore, fibers can delay the initiation of tensile cracks, effectively enhancing concrete's ability to withstand tensile strains before failure. As a result, fiber‐reinforced concrete exhibits increased durability and enhanced resistance to impacts compared to plain concrete. This study aims to evaluate and compare the cyclic flexural behavior of a cantilever beam constructed from ultra‐high‐performance fiber‐reinforced concrete (UHPFRC) using reinforcing bars made of high‐strength steel (HSS). The beams contain varying relative proportions of longitudinal reinforcement and steel fibers. Various key performance parameters of the cantilever beam were thoroughly examined, such as load capacity, flexural ductility, failure mode, hysteresis response, energy dissipation, and hardness. The study demonstrated that UHPFRC beams with HSS exhibit good cyclic flexural performance prior to failure.
Structural Optimization Design of Vacuum Interrupter Based on Transient Electric Field Distribution
Authors: Ding Can , Shi Yudong , Liu Jiayu , Jia Zhenwei 
Published: December 2024

AbstractAs the core device of vacuum circuit breaker, the insulation performance of the interrupter is closely related to the internal structure. In this paper, the electric field distribution of arc interrupter under simulated lightning impulse overvoltage is studied. It is found that the instantaneous electric field intensity is at a high level and the electric field uniformity is poor under lightning impulse. In order to further improve the electric field distribution of the interrupter, this paper proposes a method based on the combination of neural network and particle swarm optimization (PSO) to optimize the important structural parameters of the interrupter. A neural network model was established with suspension shield length (L1), suspension shield radius (R1), end shield radius (R2), contact plate thickness (H1) and end shield length (H2) as inputs, and the maximum electric field strength and the uniformity of electric field on both sides of the static and dynamic contacts as outputs, respectively. The structure of the vacuum interrupter was optimized by PSO algorithm. The optimization results show that: When the structural parameters of the vacuum interrupter H1 are 4.6 mm, H2 is 20 mm, R1 is 3.6 mm, R2 is 3.4 mm and L1 is 110 mm, the electric field distribution of the interrupter is obviously improved, and the electric field distribution of the optimized structure can also be well improved under the power frequency operating voltage. Its electric field intensity between the electrode is significantly low. © 2024 Institute of Electrical Engineers of Japan and Wiley Periodicals LLC.
Transforming the game: Rethinking leadership and character development in contemporary athletics
Authors: Luzynski Cheyenne C. , Athans Peter , Harding Jawauna 
Published: December 2024

AbstractSport plays a crucial role in personal and collective development, reflecting core values and serving as a platform for holistic growth. As athletics, especially intercollegiate sports, face increasing pressures and challenges, the need for leadership training and character development has become more critical than ever. This article emphasizes the importance of empowering student–athletes and rethinking leadership training to adapt to the evolving sports landscape. Recommendations are provided to help coaches, administrators, and athletic departments harness the transformative power of sport to develop critical leadership and life skills in young athletes.
Potential compensatory mechanisms preserving cardiac function in myotubular myopathy
Authors: Simon Alix , Diedhiou Nadège , Reiss David , Goret Marie , Grandgirard Erwan , Laporte Jocelyn 
Published: December 2024

AbstractX-Linked myotubular myopathy (XLMTM) is characterized by severe skeletal muscle weakness and reduced life expectancy. The pathomechanism and the impact of non-muscular defects affecting survival, such as liver dysfunction, are poorly understood. Here, we investigated organ-specific effects of XLMTM using the Mtm1−/y mouse model. We performed RNA-sequencing to identify a common mechanism in different skeletal muscles, and to explore potential phenotypes and compensatory mechanisms in the heart and the liver. The cardiac and hepatic function and structural integrity were assessed both in vivo and in vitro. Our findings revealed no defects in liver function or morphology. A disease signature common to several skeletal muscles highlighted dysregulation of muscle development, inflammation, cell adhesion and oxidative phosphorylation as key pathomechanisms. The heart displayed only mild functional alterations without obvious structural defects. Transcriptomic analyses revealed an opposite dysregulation of mitochondrial function, cell adhesion and beta integrin trafficking pathways in cardiac muscle compared to skeletal muscles. Despite this dysregulation, biochemical and cellular experiments demonstrated that these pathways were strongly affected in skeletal muscle and normal in cardiac muscle. Moreover, biomarkers reflecting the molecular activity of MTM1, such as PtdIns3P and dynamin 2 levels, were increased in the skeletal muscles but not in cardiac muscle. Overall, these data suggest a compensatory mechanism preserving cardiac function, pointing to potential therapeutic targets to cure the severe skeletal muscle defects in XLMTM.
Graph manifolds that admit arbitrarily many Anosov flows
Authors: Clay Adam , Pinsky Tali 
Published: December 2024

AbstractFor each natural number n, we construct an example of a graph manifold supporting at least n different Anosov flows that are not orbit equivalent. Our construction is reminiscent of the Thurston-Handel construction [11]: we cut a geodesic flow on a surface of constant negative curvature into two pieces, modify the flow in each piece by pulling back to finite covers, and glue together compatible pairs of pullback flows along their boundary tori to get many distinct flows on the resulting graph manifold.
Quillen stratification in equivariant homotopy theory
Authors: Barthel Tobias , Castellana Natàlia , Heard Drew , Naumann Niko , Pol Luca 
Published: December 2024

AbstractWe prove a version of Quillen’s stratification theorem in equivariant homotopy theory for a finite group $G$
G
, generalizing the classical theorem in two directions. Firstly, we work with arbitrary commutative equivariant ring spectra as coefficients, and secondly, we categorify it to a result about equivariant modules. Our general stratification theorem is formulated in the language of equivariant tensor-triangular geometry, which we show to be tightly controlled by the non-equivariant tensor-triangular geometry of the geometric fixed points. We then apply our methods to the case of Borel-equivariant Lubin–Tate $E$
E
-theory $\underline{E_{n}}$

E
n

_

, for any finite height $n$
n
and any finite group $G$
G
, where we obtain a sharper theorem in the form of cohomological stratification. In particular, this provides a computation of the Balmer spectrum as well as a cohomological parametrization of all localizing ⊗-ideals of the category of equivariant modules over $\underline{E_{n}}$

E
n

_

, thereby establishing a finite height analogue of the work of Benson, Iyengar, and Krause in modular representation theory.
Reordered Computable Numbers
Authors: Janicki Philip 
Published: December 2024

AbstractA real number is called left-computable if there exists a computable increasing sequence of rational numbers converging to it. In this article we are investigating a proper subset of the left-computable numbers. We say that a real number x is reordered computable if there exist a computable function $$f :\mathbb {N} \rightarrow \mathbb {N}$$

f
:
N
→
N

with $$\sum _{k=0}^{\infty } 2^{-f(k)} = x$$

∑

k
=
0

∞

2

-
f
(
k
)

=
x

and a bijective function $$\sigma :\mathbb {N} \rightarrow \mathbb {N}$$

σ
:
N
→
N

such that the rearranged series $$\sum _{k=0}^{\infty } 2^{-f(\sigma (k))}$$

∑

k
=
0

∞

2

-
f
(
σ
(
k
)
)

converges computably. In this article we will give some examples and counterexamples for reordered computable numbers and we will show that these numbers are closed under addition, multiplication and the Solovay reduction. Finally, we will also present a density theorem for reordered computable numbers.
Estimation of missing third-law standard entropy of apatite supergroup minerals using the optimized Volume-based Thermodynamics
Authors: Puzio Bartosz , Manecki Maciej 
Published: December 2024

Abstract
The thermodynamic characterization of apatite minerals, critical for understanding geological processes and material applications, faces significant challenges due to the scarcity of experimental data, particularly standard entropy (S°) values. In this study, we address this gap by optimization of predictive method based on Volume-based Thermodynamics. In the proposed method, the optimization of the widely used Volume-based Thermodynamics is based on breaking down a single linear functional relationship of formula unit volume (V
m) with S° into a set of linear equations. The apatite supergroup splits into distinct subgroups (populations) formed by Me10(AO4)6X2 with the same Me2+ cations and tetrahedral AO4
3− anions but with different anions at the X position. Our approach leverages empirical correlations between V
m and S° within specific apatite subgroups. By analyzing the correlations within the subgroups, we established the system of precise linear relationships between S° and V
m, facilitating accurate S° predictions for a wide range of apatite compositions. The proposed approach represents a significant advancement over existing predictive methods offering unparalleled accuracy in estimating S° values for apatite minerals. Through rigorous regression analysis and validation against experimental data, we demonstrate the reliability and robustness of our predictive model across various apatite subgroups. Our findings provide crucial thermodynamic data for understudied apatite compositions and shed light on fundamental relationships between crystal structure and thermodynamic properties in apatite minerals. The precise estimation of S° values enables more accurate modeling of phase equilibria, reaction kinetics, and geological processes involving apatite minerals, facilitating advancements in diverse fields ranging from environmental geochemistry to material science.
Neutrophil but not lymphocyte response to matched interval and continuous running differs between protocols and sex
Authors: Adammek F. , Belen S. , Metcalfe A. , Weißhaar F. , Joisten N. , Walzik D. , Zimmer P. 
Published: December 2024

AbstractWhen considering the acute effects of different modalities of endurance training on cellular immune components, the matching of duration and mean intensity and the consideration of sex-dependent differences have received less attention so far. The aim of the study was to compare the effects of interval running (IR) vs. continuous running (CR) on circulating immune cells and cellular immune inflammation markers. Additionally, we analyze sex-dependent differences in these effects. In a cross-over study design, 24 recreational runners completed a mean intensity and duration-matched session of IR and CR. Blood samples were taken immediately before, after, and 1 h after exercise cessation for cell counts and cortisol level quantification. Neutrophil counts showed a sustained increase after both exercise modalities with significantly greater values after IR compared to CR at 1 h after exercise and greater increases in females. Neutrophil-to-lymphocyte ratio and systemic immune-inflammation index increased 1 h after exercise with significantly higher values after IR compared to CR with greater values in females. Platelet-to-lymphocyte ratio decreased in both immediately after IR and 1 h after exercise in both sexes and modalities. The cortisol level shows a lower value immediately after CR compared to IR with no sex-dependent differences. The IR protocol induces greater immune cell mobilizations in comparison to CR, which is primarily based on a systemic increase in neutrophil counts. Neutrophil-to-lymphocyte ratio and systemic immune-inflammation index are suitable to distinguish this effect between training modalities. Sex-dependent differences confirm that biological sex influences the immune cells response to acute exercise. Protocol registration: German Clinical Trials Register, DRKS00017686, Date of registration: 11.02.2020.