bluuebunny/crossref_metadata_2025_split huggingface dataset:
Personalized Food Avoidance Dietary Approach for Psoriasis and Hypertension: A Case Study and Pilot Trial
Authors: Chijioke CP , Okafor MT , Nubila NI , Onah IC , Chijioke UO , Chigbo NN , Maduka IC , Udoh IP , Eleazar CI , Gbenimachor NM , Mbadiwe NC , Nwadike KI , Anusiem CA , Nwosu NI , Okpe AC , Muobike AT , Nwokolo BA , Udorah MI , Nnadozie OJ , Nwonu PC , Ndiokwelu CI , Okwara CC , Oji LC , Okoli UA , Uamai IM , Anakwue RC , Amah CC , Ironkwe NF , Ekwe EA , Aniagor EN , Ayuk CO , Aneziokoro EA , Onwasigwe CN , Ugwoke U , Ide C , Effiong-Essien CR , Chima-Enema N , Onyia BU , Okwy-Nweke C , Enuka HC , Onwuka-Kalu N , Obiefuna A , Okpara TC , Maduabuchi JU , Okwara CC 
Published: October 2024

Background:
The comorbidity, coheritability and common immune pathways of the inflammatory ‘chronic’ (non-communicable) diseases, suggest a shared aetiopathogenic mechanism, with phenotypic localization dependent on genetic predisposition, for example, the arteries in hypertension and the skin in psoriasis. Lifelong observation of psoriasis suggests genetically predisposed toxicity of amphiphilic fats, flavor enhancers, and nonsugar sweeteners.

Aim:
To conduct trials of personalized dietary intervention to abate the phenotypic expression of psoriasis and hypertension.

Materials and Methods:
The interventional case study of psoriasis was conducted by means of repetitive dietary challenge and avoidance testing. We then conducted an open trial of personalized nutrition on nine consenting recruits with uncomplicated essential hypertension. They were counseled on which foods to avoid or to take based on the experience gained in psoriasis. Study participants with ‘GOOD’ or ‘FAIR/POOR’ dietary compliance were compared with regard to blood pressure (BP) control, antihypertensive drug treatment requirement (ADTR), and anthropometry.

Results:
Data from four FAIR/POOR diet compliers and three GOOD compliers, as at 29 weeks of dietary intervention, showed mean systolic home BP values of 128.1 (±6.74) mmHg and 122.3 (±2.03) mmHg, respectively; the mean systolic automated office BP values were 139.8 (±8.80) mmHg and 108.3 (±5.55) mmHg, respectively; as at 39 weeks of dietary intervention, the mean ADTR scores were 4.2 (±2.12) and 1.03 (±0.57), respectively. Using data at baseline and from all available timepoints after dietary intervention, two-way ANOVA confirmed highly significant improvement of BP control (P < 0.0001) and reduction of ADTR score (P = 0.0008) in GOOD compliers. GOOD compliers exhibited significantly more reductions in BMI, abdominal circumference, and triceps skinfold thickness than FAIR/POOR compliers (two-way ANOVA and linear regression: P < 0.05).

Conclusion:
These results support the case for adverse dietary exposure avoidance to abate the phenotypic expression of chronic disease.
Effect of Glucosamine Hydrochloride Combined with Celecoxib on Inflammatory Response and Bone Metabolism in Patients with Knee Osteoarthritis
Authors: Zhang C , Mu S , Wang L , Yang Z , Sun Y 
Published: October 2024

Background:
Knee osteoarthritis is one of the common chronic degenerative joint diseases. The present study explored the efficacy of glucosamine hydrochloride combined with celecoxib in the treatment of knee osteoarthritis and its effect on inflammatory response and bone metabolism.

Material and Methods:
Ninety patients with knee osteoarthritis were randomly divided into the single treatment group and the combined treatment group, which received the treatment using single glucosamine hydrochloride and glucosamine hydrochloride combined with celecoxib for three months, respectively.

Results:
After treatment, compared with the single treatment group, in the combined treatment group the total effective rate was increased, the Visual Analogue Scale score was decreased, the Lysholm score was increased, the serum tumor necrosis factor-α, interleukin 6 and interleukin 1β levels were decreased, the serum β-C-telopeptides of type I collagen level was decreased, and the serum bone-specific alkaline phosphatase and osteocalcin levels were increased. The incidence of adverse reactions during treatment had no significant difference between two groups.

Conclusions:
Glucosamine hydrochloride combined with celecoxib has a good therapeutic efficacy for patients with knee osteoarthritis, and it can improve the bone metabolism and reduce the inflammatory response in patients.
A Retrospective Cohort Study of the Clinical Presentation and Visual Outcomes of Blepharoptosis Treatment
Authors: Atima MO , Idakwo U , Komolafe O , Shimizu E , Shintaro N , Balogun EO , Dingwoke EJ , Orugun AJ , Atima-Ayeni E , Yetunde AF , Jah PD 
Published: October 2024

Background:
Blepharoptosis (ptosis) is the drooping of the upper eyelid, which can be congenital or acquired and caused by various factors. It can lead to vision impairment, such as amblyopia in children, and reduced visual fields in adults, affecting quality of life.

Aim:
To analyze the clinical manifestation of ptosis, specifically examining the available treatment options and evaluating the resulting visual outcomes.

Methods:
A comprehensive analysis was conducted on the medical records of patients diagnosed with ptosis who received treatment through both surgical and non-surgical approaches between January 2017 and December 2020. Additionally, an examination of the underlying factors contributing to the condition was performed and presented.

Results:
A total of 28 patients, with an average age of 31.48 ± 21.66 years, received treatment at our facilities. Out of the 26 cases of unilateral ptosis, 11 patients (43%) underwent surgery, while 15 patients (57%) were treated with medications. The majority of the surgical cases were due to congenital ptosis (8 patients), followed by traumatic ptosis (3 patients). Among the patients who did not undergo surgery, neurological ptosis was present in 6 cases, while congenital ptosis was observed in 5 cases. All cases were successfully managed, resulting in good visual acuity and no complications.

Conclusion:
The most prevalent type of ptosis is congenital ptosis, which primarily affects males and tends to occur more frequently in the left eye. In acquired cases, traumatic ptosis is the most commonly observed type according to this study. After undergoing surgery, patients with congenital ptosis experienced improved visual outcomes, displaying good cosmetic appearance and achieving a visual acuity of 6/6-6/18.
Evaluation of different methods for optic port entry in the umbilical region in gynecologic laparoscopic operations
Authors: Shrief Basma M. , Borg Hesham E.S. , Awara Ahmed M. , El Naggar Ramy M. 
Published: October 2024

Background
Scarring after surgery poses a significant concern for women, particularly for those in their youth.

Aim
Evaluate which method of vertical trans umbilical and tranverse supra umbilical entry approaches in laparoscopic surgeries ought to be prioritized regarding cosmetic, pain and infection.

Patients and methods
This prospective comparative study was performed on 50 individuals aged from 18 to 60 years old, both sexes, undergoing diagnostic or operative laparoscopy for infertility, ovarian torsion, or cystectomy, chronic pelvic pain and total laparoscopic hysterectomy. Participants divided in to two groups equally: group 1: Vertical trans umbilical incision. Group 2: Transverse supra umbilical incision.

Results
There were significantly lower pain scores and overall scar scores after 1 week, 1 month, and 3 months of the operation in individuals with vertical trans umbilical incision than in patients with transverse supra umbilical incision. A substantial variation existed among both groups as regard redness warmth, tenderness, and increased pain. There was significantly lower vascularity, pigmentation, pliability, thickness sub scale scores, and overall scar scores after 1 week, 1 month, and following 3 months of the operation in individuals with trans umbilical vertical incision than in patients with supra umbilical transverse incision (P<0.05). Lower painful, itchy, stiff, irregular, and hyperpigmented scar in vertical trans umbilical incision than patients with transverse supra umbilical incision however, this difference was significant in itching and irregular scar formation (P<0.05).

Conclusion
A vertical incision provides better cosmetic outcomes compared with a transverse incision one.
Spectrophotometric determination of procaine hydrochloride using oxidative coupling and cloud point extraction
Authors: Salah Qadir Gulan , Sabeeh Othman Nabeel , Thanoon Al-Taee Amer 
Published: October 2024

A method with rapid, sensitive, accurate, and selective for estimation of local anesthetic procaine hydrochloride (PRO.HCl) is crucial, due to its bad damage to health if administrated excessively. In this work two spectrophotometric methods oxidative coupling and cloud point extraction (CPE) were utilized for determination of PRO.HCl in its standard state and pharmaceutical preparations. Method A, based on the oxidative coupling reaction using sodium hypochlorite as an oxidant and 2,5-dimethylphenol as coupling agent. The blue colored product has high absorption at 600 nm. Method B based on the CPE relying on the previous reaction, with addition of Triton X-114, after extracting the colored product, it was measured at 630 nm. Beer’s law of both methods are linear in the concentration ranges 2.50-50 µg/mL (method A) and 1.25-3.75 µg/mL (method B). The molar absorptivity coefficients of methods (A) and (B) are 4.01 x 103 and 1.34 x 104 L/mol.cm, respectively. For (method A) limit of detection and limit of quantification were calculated and found that 0.26 µg/mL and 0.87 µg/mL, respectively, while for (method B) were found to be 0.16 and 0.54 µg/mL, respectively. Both methods (A and B) are applied to evaluate PRO.HCl in pharmaceutical preparations (injection).
KEY WORDS: Cloud point extraction, 2,5-Dimethylphenol reagent, Odxiative-coupling, Procaine-hydrochloride, Spectrophotometry, Triton X-114.
Bull. Chem. Soc. Ethiop. 2025, 39(1), 1-13.
DOI: https://dx.doi.org/10.4314/bcse.v39i1.1
Synthesis, characterization, biological activity, DFT and Hirshfeld surface studies of Pd(II) and Pt(II)-1-cyclohexyl-3-phenylthiourea and amine ligands
Authors: H Khalaf Wesam , A. Al-Jibori Subhi , Ashfaq Muhammad , S. Faihan Ahmed , Nawaz Tahir Muhammad , S. M. Al-Janabi Ahmed 
Published: October 2024

A series of mixed ligand complexes of Pd(II) and Pt(II) of 1-cyclohexyl-3-phenylthiourea and diamine ligands {2,2'-bipyridyl (Bipy) and 1,10-phenanthroline (Phen)} were prepared and characterized by FT-IR, NMR spectroscopy, molar conductivity. Density functional theory (DFT) calculations and biological activity were carried out on the prepared complexes. In vitro antimicrobial activity was investigated against three pathogenic bacteria (Staphylococcus aureus, Bacillus cereus and Escherichia coli). The most active compound 6 was found more active than free ligand and other complexes. The crystal structure of the free ligand was determined by X-ray diffraction (XRD) analysis. Hirshfeld surface analysis was executed for the free ligand by finding and exploring the interatomic contacts that are important considering the supramolecular assembly of the crystal. The mechanical stability or response is prophesied by voids analysis. The supramolecular assembly is significantly uncovered by intermolecular interaction energies calculations performed at of the B3LYP/6-31G(d,p) electron density level.
KEY WORDS: Thiourea, Diamine, Crystal structure, DFT, Hirshfeld surface
Bull. Chem. Soc. Ethiop. 2025, 39(1), 15-27.
DOI: https://dx.doi.org/10.4314/bcse.v39i1.2
Developing a Taught Module on ‘Law, Religion, and Environment’
Authors: Obani Pedi 
Published: October 2024

Building on the Arab Barometer seventh wave survey, which highlights the regional priorities on climate change, water resources, and environmental development in Middle East and North Africa, this paper explores the potential for a module on “Law, Religion and Environmental Sustainability”. The module aims to mainstream environmental sustainability in the legal education curriculum through forging the intersections between law, religion, and the environment. The growing body of interdisciplinary research on religion and environmentalism mainly involves scholars from academic disciplines such as sociology, theology, and religious studies, but not law. The Arab Barometer results indicate that citizens’ environmental concerns are mostly linked to the micro level, without directly reflecting on related macro level issues. However, religious beliefs and faith systems often cut across the micro and macro levels, and could potentially advance environmental and sustainable development objectives. Moreso, there have been pockets of non-international armed conflicts that are in some ways tied to religious beliefs and cultural values on access to natural resources such as land and water. This paper addresses how to train law students to embrace and contribute to the emerging field of religion and environmentalism. Such training would equip law graduates to (a) have a good understanding of the contemporary social, economic and political context of environmental governance and sustainable development laws; (b) appreciate the interlinkages between law, religion and environment at a theoretical and practical level; and (c) be better equipped to maximise the opportunities and resolve tensions that may arise from mainstreaming legal principles, including human rights and justice, in advancing sustainable development goals, including environmental sustainability.

, , CurriculumDevelopment, MENA region, Legal Education,
Mengukur Tingkat Kesehatan Bank Melalui Metode CAMEL
Authors: Ningrum Sofi Setia , Balafif Mohammad 
Published: October 2024

Penelitian ini bertujuan untuk menganalisis tingkat kesehatan Bank X dengan menggunakan metode CAMEL (CAR, NPL, NPM, ROA, BOPO, dan ROA). Jenis penelitian yang digunakan adalah kualitatif. Data diperoleh dari situs resmi Bank X. Hasil penelitian ini menunjukan bahwa, tingkat kesehatan keuangan Bank X dilihat dari aspek permodalan (CAR) yang diperoleh dari tahun 2019-2023 menujukkan kondisi bank sangat sehat dengan rata-rata sebesar 23,37%. Aspek aset (NPL) yang diperoleh dari tahun 2019-2023 menujukkan kondisi bank cukup sehat dengan rata-rata sebesar 3,31%. Aspek manajemen (NPM) yang diperoleh dari tahun 2019-2023 menujukkan kondisi bank sehat dengan rata-rata sebesar 83,27%. Aspek rentabilitas (ROA) yang diperoleh dari tahun 2019-2023 menujukkan kondisi bank sangat sehat dengan rata-rata sebesar 1,99%. Sedangkan rasio (BOPO) menujukkan kondisi bank sangat sehat dengan rata-rata sebesar 73,25%. Aspek likuiditas (LDR) yang diperoleh dari tahun 2019-2023 menujukkan kondisi bank sangat sehat dengan rata-rata sebesar 61,59%.
Incidência da pobreza no acolhimento e desligamento institucional de crianças e adolescentes
Authors: Fonseca Antunes Ana Carolina , Coradini Guilherme Rosilaine 
Published: October 2024

Este artigo discorre sobre a proteção social destinada à infância e à adolescência no Brasil, do período colonial à contemporaneidade, a fim de constituir uma análise socioinstitucional perante o processo de acolhimento institucional, com atenção para a incidência da pobreza no decorrer desse processo. Trata-se de pesquisa qualitativa de caráter exploratório, cujos dados decorrem de fontes bibliográficas e documentais, sendo epistemologicamente amparada no método dialético crítico. No que concerne aos resultados, tem-se a pobreza como fator incidente na trajetória do acolhimento institucional. Desde as primeiras civilizações, quando esses sujeitos eram invisíveis a quaisquer direitos, até a sociedade atual, quando são culpabilizados pela realidade social a qual são submetidos. Mesmo após avanços no campo dos direitos de cidadania, como o Estatuto da Criança e do Adolescente, existem lacunas no que tange a proteção social da infância e da juventude. Como exemplo, pode-se citar as inúmeras barreiras enfrentadas no ato de desligamento e do acolhimento institucional.
Améliorer les illustrations dans les livres jeunesse à destination des enfants avec un handicap visuel : cinq pistes d’adaptation proposées ou validées par la recherche
Authors: Valente Dannyelle , Mascle Carolane , Chennaz Lola , Galiano Anna Rita , Gentaz Edouard 
Published: October 2024

Les enfants avec un handicap visuel ont besoin de livres jeunesse adaptés à leurs façons spécifiques de lire et de percevoir le monde. La première partie de cet article présente une synthèse des études ayant examiné la compréhension des illustrations dans les livres jeunesse par ces enfants. Nous explorons ensuite cinq pistes de conception d’illustrations accessibles apportées ou validées par la recherche : 1) explorations tactiles simulant des expériences réelles du corps et de la main 2) mise en avant des textures pertinentes 3) association du toucher et du son par des dispositifs multimodaux 4) personnalisation des illustrations au type de déficience visuelle 5) participation des enfants et leur entourage à la création de ces illustrations. Ces pistes prometteuses, appuyées sur des données scientifiques, ouvrent des voies à la création de livres jeunesse plus inclusifs et plus proches des besoins et des modes d’exploration spécifiques de ces enfants.
Pembelajaran Membatik dengan Zat Pewarna Alam di Studio Batik Kembang Mulyo Jepara
Authors: Khakim Achmad Luqmanul , Widagdo Jati 
Published: October 2024

Batik adalah seni dan cara menghias suatu kain dengan penutup lilin yang dalam pembentukan corak dan pola hiasnya dengan menggunakan pewarna. Dua pewarna tersebut, yaitu zat pewarna alami dan zat pewarna kimia. Dalam perkembangannya zat pewarna alami makin diminati, selain karena memiliki warna cantik dan unik juga baik untuk kulit pemakai. Untuk itu, tulisan ini bertujuan memaparkan mengenai zat pewarna alam yang dapat digunakan sebagai alternatif pewarna batik. Sifat dari penelitian adalah penelitian lapangan dan penelitian kepustakaan. Teknik penelitian dilakukan dengan berbagai langkah, diantaranya: teknik Observasi. Data yang telah diperoleh kemudian disusun dan diklasifikasikan serta dianalisa secara deskriptif kualitatif. Serta untuk mendapatkan data pelengkap penelitian ialah dengan teknik penelitian kepustakaan. Dari studi ini, didapatlah hasil pembuatan batik dengan menggunakan berbagai zat pewarna alami. Baik yang sudah sering digunakan ataupun zat pewarna alami baru yang dapat digunakan sebagai pewarnaan dalam pembuatan batik. Dalam pengaplikasian zat pewarna alami direkomendasikan untuk menggunakan bahan sekitar agar nantinya dapat menjadi ciri khas warna batik Jepara dan disarakan untuk sering mencoba, agar dihasilakan warna yang sesuai dengan yang di inginkan.
PENDIDIKAN AUD: Berpikir Kritis Berbasis Flip Chart Gambar Seri
Authors: Wahyuni Sri , Suyadi Suyadi 
Published: October 2024

Berpikir kritis sangat diperlukan di dunia seperti sekarang ini, sehingga harus diajarkan pada anak-anak sejak dini. Berpikir kritis membantu peserta didik mengembangkan keterampilan memecahkan masalah yang efektif. Sehingga peserta didik dapat menganalisis masalah, mengidentifikasi solusi, dan memilih solusi terbaik. Penelitian ini bertujuan untuk menstimulasi kemampuan berpikir kritis anak usia 4-5 tahun. Metode yang digunakan dalam penelitian ini adalah kualitatif. Teknik pengumpulan data yang digunakan adalah observasi terhadap perilaku peserta didik saat menggunakan media flip chart gambar seri dan wawancara guru dan peserta didik untuk mengetahui bagaimana pendapat mereka terhadap implementasi media tersebut. Teknik analisis data dalam penelitian ini disajikan dalam bentuk deskriptif yang bersumber dari wawancara, pada penelitian ini yang menjadi subjek penelitian adalah guru dan anak. Hasil penelitian menunjukkan bahwa media flip chart gambar seri yang digunakan dapat menstimulasi kemampuan berpikir kritis anak usia 4-5 tahun dalam memecahkan suatu masalah yang ada pada cerita gambar seri dan mampu memberikan solusi atau pendapat terkait masalah yang ada. Anak mampu memahami dan mengenali informasi lewat gambar, anak mampu mengenali hubungan sebab akibat melalui gambar, anak mampu mengevaluasi isi cerita, anak mampu memberikan kesimpulan terkait dengan isi cerita gambar seri.
Metabolic Syndrome Severity Score in Subjects with and without Poly Cystic Ovarian Syndrome
Authors: Sikandar Hayat Hhan  , Hafeez Ayesha , Shahid Rahat , Noor Chaudhry Qamar Ul Haq , Hafeez Javeria , Gillani Mehreen 
Published: October 2024

Objective: To compare polycystic ovarian syndrome and their defining criteria with metabolic syndrome severity score among females with and without polycystic ovarian syndrome.
Study Design: Comparative cross-sectional study.
Place and Duration of Study: Naval Hospital Islamabad, from Jan 2018 to Dec 2021.
Methodology: We evaluated 293 female subjects for Poly Cystic Ovarian Syndrome after several exclusions who presented with an initial complaint of disturbances in menstrual cycles. These subjects underwent clinical examination including blood pressure and anthropometric indices and measurements of modified Ferriman Gallway score. Biochemical measurements included fasting plasma glucose, HDL cholesterol, triglycerides and insulin measurement. These parameters were measured for various components included in defining the Poly Cystic Ovarian Syndrome as per Rotterdam criteria and Metabolic Syndrome Severity Score equation to compare metabolic syndrome severity and insulin resistance among subjects with Poly Cystic Ovarian Syndrome and without Poly Cystic Ovarian Syndrome.
Results: Mean age among participants were 29.46±6.74 years. Disturbances in menstrual cycle reporting oligo/anovulation was reported by (181/293) 61.8% in comparison to (112/293) 38.2%. Hirsutism (modified Ferriman Gallway score>8) was present in (142/293) 48.5%. Radiological findings pointing towards Poly Cystic Ovarian Syndrome diagnosis were found in (72/293) 24.6%. Metabolic Syndrome Severity Score showed higher correlation with age, and insulin resistance in contrast to hirsutism and free androgen indices. Hirsutism was higher among oligo/anovulation females than participants without menstrual complaints (14.17+8.99 vs. 11.16+7.88, p=0.004). Similarly, bioc
Conclusion: Metabolic Syndrome Severity Score equation does not associate with Poly Cystic Ovarian Syndrome criteria as defined by Rotterdam. Insulin resi
Association Between Helicobacter Pylori Infection and Vitiligo
Authors: Rashid Nazia , Rahman Atiya 
Published: October 2024

Objective: To determine the association between Helicobacter pylori infection and vitiligo in patients visiting a tertiary care hospital of Punjab, Pakistan.
Study Design: Case control study.
Place and Duration of Study: Department of Dermatology, Combined Military Hospital, Lahore Pakistan, from Oct 2021 to Mar 2022.
Methodology: A total of 60 adult vitiligo patients and 60 healthy controls, of both genders, were included in the study. Their ages ranged from 18-70 years. All study participants underwent stool antigen test to detect the presence of Helicobacter pylori antigen.
Results: The mean age of the cases was 43.47±8.16 years whereas it was 40.08±7.42 years in the controls. The mean duration of disease was 4.133±1.21 months. H. pylori Infection was detected in 36(60%) cases as compared to 11(18.3%) controls (p<0.001, OR=6.68); which was found to be statistically significant.
Conclusion: Significant association between H. pylori infection and vitiligo was demonstrated in the current study.