bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of emotions on heart rate asymmetry
Authors: Kaczmarek Lukasz D. , Behnke Maciej , Enko Jolanta , Kosakowski Michał , Hughes Brian M. , Piskorski Jaroslaw , Guzik Przemysław 
Published: January 2019

AbstractHeart rate asymmetry (HRA) is an index that accounts for an uneven contribution of decelerations and accelerations to the heart rate variability (HRV). Clinical studies indicated that HRA measures have additive clinical value over the more frequently used HRV indexes. Despite the abundance of studies on psychological influences on HRV, little is known whether psychological factors influence HRA. Based on previous research regarding HRA and stress, we expected that negative emotions compared to positive emotions would decrease the contribution of decelerations to HRV. Thirty female participants watched three clips that produced negative emotions, positive emotions, and neutral affect. Besides electrocardiogram, we measured several physiological and behavioral responses to ascertain the affective impact of the clips. Using the RR interval time series, we calculated HRV and HRA indexes. We found that HRA differentiated between positive emotions and negative emotions reactivity. Positive emotions produced a higher number of decelerations in short‐term variability to the total short‐term variability (C1d) compared to negative emotions. Moreover,C1dcorrelated with subjective ratings of affect. In sum, the results of this study indicated that HRA is sensitive to psychological influences. HRA indexes are likely to contribute to a more nuanced physiological differentiation between emotions.
Cell therapy for ARDS: efficacy of endobronchial versus intravenous administration and biodistribution of MAPCs in a large animal model
Authors: Cardenes Nayra , Aranda-Valderrama Paola , Carney Jonathan P , Sellares Torres Jacobo , Alvarez Diana , Kocyildirim Ergin , Wolfram Smith Julie A , Ting Antony E , Lagazzi Luigi , Yu Zheming , Mason Scott , Santos Ernesto , Lopresti Brian J , Rojas Mauricio 
Published: January 2019

IntroductionBone marrow-derived multipotent adult progenitor cells (MAPCs) are adult allogeneic adherent stem cells currently investigated clinically for use in acute respiratory distress syndrome (ARDS). To date, there is no agreement on which is the best method for stem cells delivery in ARDS. Here, we compared the efficacy of two different methods of administration and biodistribution of MAPC for the treatment of ARDS in a sheep model.MethodsMAPC were labelled with [18F] fluoro-29-deoxy-D-glucose and delivered by endobronchial (EB) or intravenous route 1 hour after lipopolysaccharide infusion in sheep mechanically ventilated. PET/CT images were acquired to determine the biodistribution and retention of the cells at 1 and 5 hours of administration.ResultsThe distribution and retention of the MAPC was dependent on the method of cell administration. By EB route, PET images showed that MAPC remained at the site of administration and no changes were observed after 5 hours, whereas with intravenous route, the cells had broad biodistribution to different organs, being the lung the main organ of retention at 1 and 5 hours. MAPC demonstrated an equal effect on arterial oxygenation recovery by either route of administration.ConclusionThe EB or intravenous routes of administration of MAPC are both effective for the treatment of ARDS in an acute sheep model, and the effect of MAPC therapy is not dependent of parenchymal integration or systemic biodistribution.
Which parameters to use for sleep quality monitoring in team sport athletes? A systematic review and meta-analysis
Authors: Claudino João Gustavo , J Gabbett Tim , de Sá Souza Helton , Simim Mário , Fowler Peter , de Alcantara Borba Diego , Melo Marco , Bottino Altamiro , Loturco Irineu , D’Almeida Vânia , Carlos Amadio Alberto , Cerca Serrão Julio , P Nassis George 
Published: January 2019

BackgroundSleep quality is an essential component of athlete’s recovery. However, a better understanding of the parameters to adequately quantify sleep quality in team sport athletes is clearly warranted.ObjectiveTo identify which parameters to use for sleep quality monitoring in team sport athletes.MethodsSystematic searches for articles reporting the qualitative markers related to sleep in team sport athletes were conducted in PubMed, Scopus, SPORTDiscus and Web of Science online databases. The systematic review followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. For the meta-analysis, effect sizes with 95% CI were calculated and heterogeneity was assessed using a random-effects model. The coefficient of variation (CV) with 95% CI was also calculated to assess the level of instability of each parameter.ResultsIn general, 30 measuring instruments were used for monitoring sleep quality. A meta-analysis was undertaken on 15 of these parameters. Four objective parameters inferred by actigraphy had significant results (sleep efficiency with small CV and sleep latency, wake episodes and total wake episode duration with large CV). Six subjective parameters obtained from questionnaires and scales also had meaningful results (Pittsburgh Sleep Quality Index (sleep efficiency), Likert scale (Hooper), Likert scale (no reference), Liverpool Jet-Lag Questionnaire, Liverpool Jet-Lag Questionnaire (sleep rating) and RESTQ (sleep quality)).ConclusionsThese data suggest that sleep efficiency using actigraphy, Pittsburgh Sleep Quality Index, Likert scale, Liverpool Jet-Lag Questionnaire and RESTQ are indicated to monitor sleep quality in team sport athletes.PROSPERO registration numberCRD42018083941.
Accuracy of a point-of-care test for quantifying human chorionic gonadotrophin (hCG) in the management of pregnancy of unknown location in an abortion service
Authors: Reynolds-Wright John Joseph , Main Peter , Cameron Sharon T 
Published: January 2019

IntroductionWomen may seek abortion at gestations when there is no visible intrauterine pregnancy on ultrasound scanning. Clinical protocols for pregnancy of unknown location (PUL) require measurement of serum human chorionic gonadotrophin (hCG), with the National Institute for Health and Care Excellence recommending that values above 1500 IU/L be further investigated to exclude ectopic pregnancy. Our aim was to determine whether a point-of-care test (POCT) could be used instead of laboratory serum hCG measurement.MethodsOver 12 months, women who presented to an abortion service with a PUL had a POCT for blood or urine hCG and laboratory serum hCG measurement. The POCT machine used provides a discrete hCG value below 1000 IU/L and above this gives results as a range. The sensitivity and specificity of the POCT in identifying cases where laboratory serum hCG results were above 1500 IU/L were calculated.ResultsA total of 118 women presented with a PUL, of whom 70 had a POCT on blood (n=49) or urine (n=21) and a corresponding laboratory serum hCG. The sensitivity of the blood POCT was 0.67 (95% CI 0.38 to 0.87) and the specificity was 0.97 (95% CI 0.83 to 0.99). The sensitivity of the urine POCT was 0.25 (CI 0.01 to 0.78) and the specificity was 0.94 (CI 0.69 to 0.99).ConclusionAlthough both the blood and urine POCTs had a high level of specificity, neither test was acceptably sensitive. While promising, this POCT for hCG is not sufficiently reliable to replace laboratory serum hCG testing in the management of women with PUL in an abortion service.
Comparison of fingolimod, dimethyl fumarate and teriflunomide for multiple sclerosis
Authors: Kalincik Tomas , Kubala Havrdova Eva , Horakova Dana , Izquierdo Guillermo , Prat Alexandre , Girard Marc , Duquette Pierre , Grammond Pierre , Onofrj Marco , Lugaresi Alessandra , Ozakbas Serkan , Kappos Ludwig , Kuhle Jens , Terzi Murat , Lechner-Scott Jeannette , Boz Cavit , Grand'Maison Francois , Prevost Julie , Sola Patrizia , Ferraro Diana , Granella Franco , Trojano Maria , Bergamaschi Roberto , Pucci Eugenio , Turkoglu Recai , McCombe Pamela A , Pesch Vincent Van , Van Wijmeersch Bart , Solaro Claudio , Ramo-Tello Cristina , Slee Mark , Alroughani Raed , Yamout Bassem , Shaygannejad Vahid , Spitaleri Daniele , Sánchez-Menoyo José Luis , Ampapa Radek , Hodgkinson Suzanne , Karabudak Rana , Butler Ernest , Vucic Steve , Jokubaitis Vilija , Spelman Tim , Butzkueven Helmut 
Published: January 2019

ObjectiveOral immunotherapies have become a standard treatment in relapsing-remitting multiple sclerosis. Direct comparison of their effect on relapse and disability is needed.MethodsWe identified all patients with relapsing-remitting multiple sclerosis treated with teriflunomide, dimethyl fumarate or fingolimod, with minimum 3-month treatment persistence and disability follow-up in the global MSBase cohort study. Patients were matched using propensity scores. Three pairwise analyses compared annualised relapse rates and hazards of disability accumulation, disability improvement and treatment discontinuation (analysed with negative binomial models and weighted conditional survival models, with pairwise censoring).ResultsThe eligible cohorts consisted of 614 (teriflunomide), 782 (dimethyl fumarate) or 2332 (fingolimod) patients, followed over the median of 2.5 years. Annualised relapse rates were lower on fingolimod compared with teriflunomide (0.18 vs 0.24; p=0.05) and dimethyl fumarate (0.20 vs 0.26; p=0.01) and similar on dimethyl fumarate and teriflunomide (0.19 vs 0.22; p=0.55). No differences in disability accumulation (p≥0.59) or improvement (p≥0.14) were found between the therapies. In patients with ≥3-month treatment persistence, subsequent discontinuations were less likely on fingolimod than teriflunomide and dimethyl fumarate (p<0.001). Discontinuation rates on teriflunomide and dimethyl fumarate were similar (p=0.68).ConclusionThe effect of fingolimod on relapse frequency was superior to teriflunomide and dimethyl fumarate. The effect of the three oral therapies on disability outcomes was similar during the initial 2.5 years on treatment. Persistence on fingolimod was superior to the two comparator drugs.
Validation studies of virtual reality simulation performance metrics for mechanical thrombectomy in ischemic stroke
Authors: Crossley Robert , Liebig Thomas , Holtmannspoetter Markus , Lindkvist Johan , Henn Pat , Lonn Lars , Gallagher Anthony Gerald 
Published: January 2019

IntroductionMechanical thrombectomy (MT) has transformed the treatment of ischemic stroke. However, patient access to MT may be limited due to a shortage of doctors specifically trained to perform MT. The studies reported here were done to (1) develop, operationally define, and seek consensus from procedure experts on the metrics which best characterize a reference procedure for the performance of an MT for ischemic stroke and (2) evaluate their construct validity when implemented in a virtual reality (VR) simulation.MethodsIn study 1, the metrics for a reference approach to an MT procedure for ischemic stroke of 10 phases, 46 steps, and 56 errors and critical errors, were presented to an international Delphi panel of 21 consultant level interventional neuroradiologists (INRs). In study 2, the metrics were used to assess 8 expert and 10 novice INRs performing a VR simulated routine MT procedure.ResultsIn study 1, the Delphi panel reached consensus on the appropriateness of the procedure metrics for a reference approach to MT in ischemic stroke. Group differences in median scores in study 2 demonstrated that experienced INRs performed the case 19% faster (P=0.029), completed 40% more procedure phases (P=0.009), 20% more steps (P=0.012), and made 42% fewer errors (P=0.016) than the novice group.ConclusionsThe international Delphi panel agreed metrics implemented in a VR simulation of MT distinguished between the computer scored procedure performance of INR experts and novices. The studies reported here support the demonstration of face, content, and construct validity of the MT metrics.
Assessing mineral fertility and bias in sedimentary provenance studies: examples from the Barents Shelf
Authors: Flowerdew Michael J. , Fleming Edward J. , Morton Andrew C. , Frei Dirk , Chew David M. , Daly J. Stephen 
Published: January 2019

Abstract

The development of laser ablation techniques using inductively coupled plasma mass spectrometry has enabled the routine and fast acquisition of
in situ
U–Pb and Pb–Pb isotope ratio data from single detrital grains or parts of grains. Detrital zircon dating is a technique that is increasingly applied to sedimentary provenance studies. However, sand routing information using zircon analysis alone may be obscured by repeated sedimentary reworking cycles and mineral fertility variations. These biases are illustrated by two clear case studies from the Triassic–Jurassic of the Barents Shelf where the use of U–Pb geochronology on apatite and rutile and Pb–Pb isotopic data from K-feldspar is highly beneficial for provenance interpretations. In the first case study, U–Pb apatite ages from the (Induan – Norian) Havert, Kobbe and Snadd formations indicate an evolving provenance and identify possible episodes of storage within foreland basins prior to delivery onto the Barents Shelf. In the second case study, U–Pb rutile and Pb isotopic analyses of K-feldspar from the Norian–Pliensbachian Realgrunnen Subgroup provide a clear distinction between north Norwegian Caledonides and Fennoscandian Shield sources and suggest that a similar approach may be used to test competing models for sand dispersal for this Subgroup in regions farther north than this study.
Evaluating Local Disaster Recovery Strategies
Authors: Oostenbrink Jorik , Kuipers Fernando A. , Heegaard Poul E. , Helvik Bjarne E. 
Published: January 2019

It is of vital importance to maintain at least some network functionality after a disaster, for example by temporarily replacing damaged nodes by emergency nodes. We propose a framework to evaluate different node replacement strategies, based on a large set of representative disasters.
We prove that computing the optimal choice of nodes to replace is an NP-hard problem and propose several simple strategies. We evaluate these strategies on two U.S. topologies and show that a simple greedy strategy can perform close to optimal.
Special Issue on the Work-in-Progress (WIP) session at the ACM SIGMETRICS 2018 Conference
Authors: Liu Zhenhua , Ananthanarayanan Ganesh 
Published: January 2019

The ACM SIGMETRICS 2018 conference was held in Irvine, CA, USA. For the first time, we organized the Work-in-Progress (WIP) session. This session provided a great opportunity to present earlystage research to receive valuable feedback from the community through a dedicated poster session.
Topics fell within the purview of the SIGMETRICS main conference. Within these topics, we particularly encouraged (but were not limited to) submissions that are pursuing new, perhaps controversial, directions. We also welcomed submissions of posters corresponding to results presented at the SIGMETRICS-affiliated workshops.
Anewcategory of posterswe introduced, unlike poster sessions at other conferences, is about systems published at related conference venues (such as SOSP, SIGCOMM, NSDI) that could benefit froma thorough analytical modeling. Thework in conferences like SOSP, SIGCOMM and NSDI tend to focus on the systemic architecture but often do not do a thorough job of analytically grounding their solutions. For submissions in this category, we asked the authors to clearly explain why the poster is relevant to the SIGMETRICS community.
Submissions were judged based on their novelty as well as the potential to generate discussions. Eleven submissionswere accepted with attendance from USA and Asia. Topics range from cloud computing, power systems, security, to vehicular caching.
ACM SIGIR Annual Business Meeting 2018
Authors: Yilmaz Emine 
Published: January 2019

The 2018 ACM SIGIR Annual Business Meeting took place on Wednesday July 11, 2018, at the SIGIR'18 Conference in Ann Arbor, Michigan, USA. The meeting was held between 13:00-14:30 and was led by the chair of SIGIR Executive Committee, Diane Kelly.
The meeting started with an introduction to the executive committee, which involves Diane Kelly (University of Tennessee) as the chair, Jaap Kamps (University of Amsterdam) as the vice chair, Emine Yilmaz (University College London) as the secretary, Ben Carterette (University of Delaware) as the treasurer and Charles Clarke (University of Waterloo) as the past chair. Apart from the executive committee, volunteers play an important role in running SIGIR. Diane introduced and thanked the volunteers for 2017-2018. The volunteers for this period were Nattiya Kanhabua & Guido Zuccon (Information Directors), Jaime Arguello (Student Travel Awards Chair), Craig Macdonald (June Forum Editor), Claudia Hauff (December Forum editor), Falk Scholer (Awards Chair), Laura Dietz (Student Affairs Chair), Yoelle Maarek (Industy Liaison), Jimmy Lin (CIKM Conference Liaison), Sue Dumais (WSDM Conference Liaison) and Edie Rasmussen (JCDL Conference Liaison).
The upcoming year is an election year for the SIGIR Executive Committee. As part of this, new elections will be done for the chair, vice chair, secretary and treasurer positions. This year the committee also introduces a new volunteer position, the Diversity, Equity and Inclusion Chair whose role will be to increase diversity and inclusion at SIGIR. This position will also be filled for the upcoming year. Alistair Moffat will be leading the election process as the Election Official.
Circulating Tumor DNA in Advanced Anal Cancer: A Blood Biomarker Goes Viral
Authors: Morris Van K. 
Published: January 2019

Abstract
Circulating tumor DNA (ctDNA) as a blood-based biomarker for mutation detection is an exciting, highly sensitive approach in the clinical management of oncology patients. In human papillomavirus–associated malignancies like anal cancer, a viral-specific probe can be utilized for ctDNA detection in the majority of patients to predict clinical outcomes.
See related article by Bernard-Tessier et al., p. 2109
SPHK1 Is a Novel Target of Metformin in Ovarian Cancer
Authors: Hart Peter C. , Chiyoda Tatsuyuki , Liu Xiaojing , Weigert Melanie , Curtis Marion , Chiang Chun-Yi , Loth Rachel , Lastra Ricardo , McGregor Stephanie M. , Locasale Jason W. , Lengyel Ernst , Romero Iris L. 
Published: January 2019

AbstractThe role of phospholipid signaling in ovarian cancer is poorly understood. Sphingosine-1-phosphate (S1P) is a bioactive metabolite of sphingosine that has been associated with tumor progression through enhanced cell proliferation and motility. Similarly, sphingosine kinases (SPHK), which catalyze the formation of S1P and thus regulate the sphingolipid rheostat, have been reported to promote tumor growth in a variety of cancers. The findings reported here show that exogenous S1P or overexpression of SPHK1 increased proliferation, migration, invasion, and stem-like phenotypes in ovarian cancer cell lines. Likewise, overexpression of SPHK1 markedly enhanced tumor growth in a xenograft model of ovarian cancer, which was associated with elevation of key markers of proliferation and stemness. The diabetes drug, metformin, has been shown to have anticancer effects. Here, we found that ovarian cancer patients taking metformin had significantly reduced serum S1P levels, a finding that was recapitulated when ovarian cancer cells were treated with metformin and analyzed by lipidomics. These findings suggested that in cancer the sphingolipid rheostat may be a novel metabolic target of metformin. In support of this, metformin blocked hypoxia-induced SPHK1, which was associated with inhibited nuclear translocation and transcriptional activity of hypoxia-inducible factors (HIF1α and HIF2α). Further, ovarian cancer cells with high SPHK1 were found to be highly sensitive to the cytotoxic effects of metformin, whereas ovarian cancer cells with low SPHK1 were resistant. Together, the findings reported here show that hypoxia-induced SPHK1 expression and downstream S1P signaling promote ovarian cancer progression and that tumors with high expression of SPHK1 or S1P levels might have increased sensitivity to the cytotoxic effects of metformin.Implications:Metformin targets sphingolipid metabolism through inhibiting SPHK1, thereby impeding ovarian cancer cell migration, proliferation, and self-renewal.
Serine Threonine Kinase 17A Maintains the Epithelial State in Colorectal Cancer Cells
Authors: Short Sarah P. , Thompson Joshua J. , Bilotta Anthony J. , Chen Xi , Revetta Frank L. , Washington M. Kay , Williams Christopher S. 
Published: January 2019

Abstract

Serine threonine kinase 17A (STK17A) is a ubiquitously expressed kinase originally identified as a regulator of apoptosis; however, whether it functionally contributes to colorectal cancer has not been established. Here, we have analyzed STK17A in colorectal cancer and demonstrated decreased expression of STK17A in primary tumors, which is further reduced in metastatic lesions, indicating a potential role in regulating the metastatic cascade. Interestingly, changes in STK17A expression did not modify proliferation, apoptosis, or sensitivity of colorectal cancer cell lines to treatment with the chemotherapeutic 5-fluorouracil. Instead, STK17A knockdown induced a robust mesenchymal phenotype consistent with the epithelial–mesenchymal transition, including spindle-like cell morphology, decreased expression of adherens junction proteins, and increased migration and invasion. Additionally, overexpression of STK17A decreased cell size and induced widespread membrane blebbing, a phenotype often associated with activation of cell contractility. Indeed, STK17A-overexpressing cells displayed heightened phosphorylation of myosin light chain in a manner dependent on STK17A catalytic activity. Finally, patient-derived tumor organoid cultures were used to more accurately determine STK17A's effect in primary human tumor cells. Loss of STK17A induced morphologic changes, decreased E-cadherin, increased invasion, and augmented organoid attachment on 2D substrates, all together suggesting a more metastatic phenotype. Collectively, these data indicate a novel role for STK17A in the regulation of epithelial phenotypes and indicate its functional contribution to colorectal cancer invasion and metastasis.

Implications:
Loss of serine threonine kinase 17A occurs in colorectal cancer metastasis, induces mesenchymal morphologies, and contributes to tumor cell invasion and migration in colorectal cancer.