bluuebunny/crossref_metadata_2025_split huggingface dataset:
Maternal probiotic milk intake during pregnancy and breastfeeding complications in the Norwegian Mother and Child Cohort Study
Authors: Karlsson Sofiia , Brantsæter Anne-Lise , Meltzer Helle Margrete , Jacobsson Bo , Barman Malin , Sengpiel Verena 
Published: September 2019

Abstract

Purpose
During the time of breastfeeding, a third of all women contract (or: fall ill in) mastitis—the leading cause of precocious weaning. Recent studies indicate that probiotics intake may prevent mastitis by altering the breast’s bacterial flora. The aim of this study was to examine whether probiotic milk intake during pregnancy is associated with less breastfeeding complications and longer breastfeeding duration.

Methods
This study included 57,134 women, with live singleton term births, participating in the Norwegian Mother and Child Cohort Study. Probiotic milk intake during the first half of pregnancy was self-reported in a validated food frequency questionnaire at gestational week 22. At 6 month postpartum, women reported complications, including mastitis, and duration and exclusivity of breastfeeding. The association between probiotic milk intake and breastfeeding complications and duration was studied by adjusted logistic regression models.

Results
Probiotic milk intake was associated with increased risk for mastitis [adjusted odds ratio (aOR) 1.09, 95% confidence interval (CI) 1.02–1.16] and for any breastfeeding problems during the first month (aOR 1.19, 95% CI 1.10–1.21). However, cessation of predominant (aOR 0.95, 95% CI 0.91–0.96) or any (aOR 0.79, 95% CI 0.75–0.84) breastfeeding earlier than at 4 months was less frequent in probiotic milk consumers than in non-consumers.

Conclusions
Even though probiotic milk intake during the first half of pregnancy was statistically associated with increased risk for breastfeeding complications, including mastitis, the association is probably not causal. Probiotics intake was namely associated with longer breastfeeding duration and there was indication of socioeconomic confounding. Further studies, i.e., large randomized-controlled trials, are needed to understand the association between probiotic intake and breastfeeding complications.
Metabolically and immunologically beneficial impact of extra virgin olive and flaxseed oils on composition of gut microbiota in mice
Authors: Millman Jasmine , Okamoto Shiki , Kimura Aoki , Uema Tsugumi , Higa Moeko , Yonamine Masato , Namba Toyotaka , Ogata Emi , Yamazaki Satoru , Shimabukuro Michio , Tsutsui Masato , Matsushita Masayuki , Ikematsu Shinya , Masuzaki Hiroaki 
Published: September 2019

Abstract

Purpose
Extra virgin olive oil (EVOO) and flaxseed oil (FO) contain a variety of constituents beneficial for chronic inflammation and cardio-metabolic derangement. However, little is known about the impact of EVOO and FO on dysbiosis of gut microbiota, intestinal immunity, and barrier. We, therefore, aimed to assess the impact of EVOO and FO on gut microbiota, mucosal immunity, barrier integrity, and metabolic health in mice.

Methods
C57BL/6 J mice were exposed to a low-fat (LF), lard (HF), high fat-extra virgin olive oil (HF-EVOO), or high fat-flaxseed oil (HF-FO) diet for 10 weeks. Gut microbiota assessment was undertaken using 16S rRNA sequencing. Levels of mRNA for genes involved in intestinal inflammation and barrier maintenance in the intestine and bacterial infiltration in the liver were measured by qPCR.

Results
HF-EVOO or HF-FO mice showed greater diversity in gut microbiota as well as a lower abundance of the Firmicutes phylum in comparison with HF mice (P < 0.05). The qPCR analyses revealed that mRNA level of FoxP3, a transcription factor, and IL-10, an inducer of regulatory T cells, was significantly elevated in the intestines of mice-fed HF-EVOO in comparison with mice-fed HF (P < 0.05). The mRNA level of the antimicrobial peptide, RegӀӀӀγ, was markedly elevated in the intestines of HF-EVOO and HF-FO compared with HF group (P < 0.05).

Conclusions
Our data suggest that the consumption of EVOO or FO can beneficially impact gut microbiota, enhance gut immunity, and assist in the preservation of metabolic health in mice.
Altered motor, anxiety-related and attentional task performance at baseline associate with multiple gene copies of the vesicular acetylcholine transporter and related protein overexpression in ChAT::Cre+ rats
Authors: Mantanona Craig P. , Alsiö Johan , Elson Joanna L. , Fisher Beth M. , Dalley Jeffrey W. , Bussey Timothy , Pienaar Ilse S. 
Published: September 2019

AbstractTransgenic rodents expressing Cre recombinase cell specifically are used for exploring mechanisms regulating behavior, including those mediated by cholinergic signaling. However, it was recently reported that transgenic mice overexpressing a bacterial artificial chromosome containing choline acetyltransferase (ChAT) gene, for synthesizing the neurotransmitter acetylcholine, present with multiple vesicular acetylcholine transporter (VAChT) gene copies, resulting in altered cholinergic tone and accompanying behavioral abnormalities. Since ChAT::Cre+ rats, used increasingly for understanding the biological basis of CNS disorders, utilize the mouse ChAT promotor to control Cre recombinase expression, we assessed for similar genotypical and phenotypical differences in such rats compared to wild-type siblings. The rats were assessed for mouse VAChT copy number, VAChT protein expression levels and for sustained attention, response control and anxiety. Rats were also subjected to a contextual fear conditioning paradigm using an unconditional fear-inducing stimulus (electrical foot shocks), with blood samples taken at baseline, the fear acquisition phase and retention testing, for measuring blood plasma markers of hypothalamic–pituitary–adrenal gland (HPA)-axis activity. ChAT::Cre+ rats expressed multiple mouse VAChT gene copies, resulting in significantly higher VAChT protein expression, revealed anxiolytic behavior, hyperlocomotion and deficits in tasks requiring sustained attention. The HPA-axis was intact, with unaltered circulatory levels of acute stress-induced corticosterone, leptin and glucose. Our findings, therefore, reveal that in ChAT::Cre+ rats, VAChT overexpression associates with significant alterations of certain cognitive, motor and affective functions. Although highly useful as an experimental tool, it is essential to consider the potential effects of altered cholinergic transmission on baseline behavior in ChAT::Cre rats.
Late-onset Niemann–Pick disease type C overlapping with frontotemporal dementia syndromes: a case report
Authors: Balázs Nóra , Milanovich Dániel , Hornyák Csilla , Bereczki Dániel , Kovács Tibor 
Published: September 2019

Abstract
The diagnosis of adult-onset Niemann–Pick disease type C (NPC) could be difficult because its primary symptoms [dementia and vertical supranuclear gaze palsy (VSGP)] are mainly seen in neurodegenerative dementias and progressive supranuclear palsy (PSP). Our patient with dementia and asymmetric parkinsonism resembled corticobasal syndrome and after the appearance of VSGP, the criteria of PSP were fulfilled too. Cerebellar symptoms appeared late during the course of the disease, leading to the diagnosis of NPC at the age of 59 years.
Heterospecific alarm-call recognition in two warbler hosts of common cuckoos
Authors: Yu Jiangping , Lu Hailin , Sun Wei , Liang Wei , Wang Haitao , Møller Anders Pape 
Published: September 2019

Abstract
Species facing similar selection pressures should recognize heterospecific alarm signals. However, no study has so far examined heterospecific alarm-call recognition in response to parasitism by cuckoos. In this study, we tested whether two sympatric host species of the common cuckoo Cuculus canorus, Oriental reed warbler Acrocephalus orientalis (ORW, main host), and black-browed reed warbler Acrocephalus bistrigiceps (BRW, rare host), could recognize each other’s alarm calls in response to cuckoos. Dummies of common cuckoo (parasite) and Eurasian sparrowhawk Accipiter nisus (predator) were used to induce and record alarm calls of the two warbler species, respectively. In the conspecific alarm-call playback experiments, ORW responded more strongly to cuckoo alarm calls than to sparrowhawk alarm calls, while BRW responded less strongly to cuckoo alarm calls than to sparrowhawk alarm calls. In the heterospecific alarm-call playback experiments, both ORW and BRW responded less strongly to cuckoo alarm calls than sparrowhawk alarm calls. BRW seemed to learn the association between parasite-related alarm calls of the ORW and the cuckoo by observing the process of ORW attacking cuckoos. In contrast, alarm calls of BRW to cuckoos were rarely recorded in most cases. BRW with low parasite pressure still developed recognition of heterospecific parasite-related alarm call. Unintended receivers in the same community should recognize heterospecific alarm calls precisely to extract valuable information.
Strategies to improve the quality of life in patients with hereditary transthyretin amyloidosis (hATTR) and autonomic neuropathy
Authors: Gendre Thierry , Planté-Bordeneuve Violaine 
Published: September 2019

Abstract

Purpose
Hereditary transthyretin amyloidosis (hATTR) is a severe adult-onset progressive disease mainly involving the peripheral nervous system and the heart, with a prominent impact on the autonomic nervous system. This review summarizes the clinical aspects of autonomic dysfunction in hATTR, and their impact on quality of life as well as potential therapeutic options.

Methods
Literature review.

Results
Autonomic dysfunction, causing neurogenic orthostatic hypotension, gastroparesis, constipation, diarrhea, bladder dysfunction, and erectile dysfunction in males, has a major impact on the quality of life of patients with hATTR. Improvement of qualify of life in patients with hATTR implies periodic symptomatic screening and early management, taking into consideration comorbidities and medication side effects. The specific effect of the disease-modifying treatment on this aspect remains to be unraveled.

Conclusions
Management of autonomic dysfunction in patients with hAATR is feasible and can result in improved qualify of life. Novel disease-modifying treatments for hAATR may contribute to improve autonomic dysfunction, although specific studies are required.
Parametrizing Horizontally-Averaged Wind and Temperature Profiles in the Urban Roughness Sublayer
Authors: Theeuwes Natalie E. , Ronda Reinder J. , Harman Ian N. , Christen Andreas , Grimmond C. Sue B. 
Published: September 2019

Abstract
Tower-based measurements from within and above the urban canopy in two cities are used to evaluate several existing approaches that parametrize the vertical profiles of wind speed and temperature within the urban roughness sublayer (RSL). It is shown that current use of Monin–Obukhov similarity theory (MOST) in numerical weather prediction models can be improved upon by using RSL corrections when modelling the vertical profiles of wind speed and friction velocity in the urban RSL using MOST. Using anisotropic building morphological information improves the agreement between observed and parametrized profiles of wind speed and momentum fluxes for selected methods. The largest improvement is found when using dynamically-varying aerodynamic roughness length and displacement height. Adding a RSL correction to MOST, however, does not improve the parametrization of the vertical profiles of temperature and heat fluxes. This is expected since sources and sinks of heat are assumed uniformly distributed through a simple flux boundary condition in all RSL formulations, yet are highly patchy and anisotropic in a real urban context. Our results can be used to inform the choice of surface-layer representations for air quality, dispersion, and numerical weather prediction applications in the urban environment.
Biomass residues as twenty-first century bioenergy feedstock—a comparison of eight integrated assessment models
Authors: Hanssen Steef V. , Daioglou Vassilis , Steinmann Zoran J. N. , Frank Stefan , Popp Alexander , Brunelle Thierry , Lauri Pekka , Hasegawa Tomoko , Huijbregts Mark A. J. , Van Vuuren Detlef P. 
Published: September 2019

AbstractIn the twenty-first century, modern bioenergy could become one of the largest sources of energy, partially replacing fossil fuels and contributing to climate change mitigation. Agricultural and forestry biomass residues form an inexpensive bioenergy feedstock with low greenhouse gas (GHG) emissions, if harvested sustainably. We analysed quantities of biomass residues supplied for energy and their sensitivities in harmonised bioenergy demand scenarios across eight integrated assessment models (IAMs) and compared them with literature-estimated residue availability. IAM results vary substantially, at both global and regional scales, but suggest that residues could meet 7–50% of bioenergy demand towards 2050, and 2–30% towards 2100, in a scenario with 300 EJ/year of exogenous bioenergy demand towards 2100. When considering mean literature-estimated availability, residues could provide around 55 EJ/year by 2050. Inter-model differences primarily arise from model structure, assumptions, and the representation of agriculture and forestry. Despite these differences, drivers of residues supplied and underlying cost dynamics are largely similar across models. Higher bioenergy demand or biomass prices increase the quantity of residues supplied for energy, though their effects level off as residues become depleted. GHG emission pricing and land protection can increase the costs of using land for lignocellulosic bioenergy crop cultivation, which increases residue use at the expense of lignocellulosic bioenergy crops. In most IAMs and scenarios, supplied residues in 2050 are within literature-estimated residue availability, but outliers and sustainability concerns warrant further exploration. We conclude that residues can cost-competitively play an important role in the twenty-first century bioenergy supply, though uncertainties remain concerning (regional) forestry and agricultural production and resulting residue supply potentials.
Toward the molecular understanding of the action mechanism of Ascophyllum nodosum extracts on plants
Authors: De Saeger Jonas , Van Praet Stan , Vereecke Danny , Park Jihae , Jacques Silke , Han Taejun , Depuydt Stephen 
Published: September 2019

Abstract
The importance of biostimulants, defined as plant growth-promoting agents that differ notably from fertilizers, is increasing steadily because of their potential contribution to a worldwide strategy for securing food production without burdening the environment. Based on folkloric evidence and ethnographic studies, seaweeds have been useful for diverse human activities through time, including medicine and agriculture. Currently, seaweed extracts, especially those derived from the common brown alga Ascophyllum nodosum, represent an interesting category of biostimulants. Although A. nodosum extracts (abbreviated ANEs) are readily used because of their capacity to improve plant growth and to mitigate abiotic and biotic stresses, fundamental insights into how these positive responses are accomplished are still fragmentary. Generally, the effects of ANEs on plants have been attributed to their hormonal content, their micronutrient value, and/or the presence of alga-specific polysaccharides, betaines, polyamines, and phenolic compounds that would, alone or in concert, bring about the observed phenotypic effects. However, only a few of these hypotheses have been validated at the molecular level. Transcriptomics and metabolomics are now emerging as tools to dissect the action mechanisms exerted by ANEs. Here, we provide an overview of the available in planta molecular data that shed light on the pathways modulated by ANEs that promote plant growth and render plants more resilient to diverse stresses, paving the way toward the elucidation of the modus operandi of these extracts.
Psychological Outcomes of a Cognitive Behavioral Therapy for Youth with Inflammatory Bowel Disease: Results of the HAPPY-IBD Randomized Controlled Trial at 6- and 12-Month Follow-Up
Authors: Stapersma Luuk , van den Brink Gertrude , van der Ende Jan , Szigethy Eva M. , Groeneweg Michael , de Bruijne Frederieke H. , Hillegers Manon H. J. , Escher Johanna C. , Utens Elisabeth M. W. J. 
Published: September 2019

AbstractYouth with inflammatory bowel disease (IBD) often experience psychological difficulties, such as anxiety and depression. This randomized controlled study tested whether a 3-month disease-specific cognitive behavioral therapy (CBT) in addition to standard medical care versus standard medical care only was effective in improving these youth’s psychological outcomes. As this study was aimed at prevention, we included 70 youth (10–25 years) with IBD and symptoms of subclinical anxiety and/or depression, and measured psychological outcomes at 6- and 12-month follow-up. In general, participants in both groups showed improvements in anxiety, depression, health-related quality of life, social functioning, coping, and illness perceptions, sustained until 12 months follow-up. Overall, we found no differences between those receiving additional CBT and those receiving standard medical care only. We assume that this can be explained by the perceived low burden (both somatically and psychologically) or heightened awareness of psychological difficulties and IBD. ClinicalTrials.gov NCT02265588.
Psychometric Properties of a Polish Version of the Parental Stress Index III (PSI III)
Authors: Pisula Ewa , Barańczuk Urszula 
Published: September 2019

Abstract
The Parenting Stress Index (PSI) has been translated into multiple languages. The aim of the present study was to develop a Polish version of the PSI III. A total sample size of 678 parents (308 parents of children with ASD, 59 parents of children with Down syndrome, 65 parents of deaf children, 34 parents of children with other developmental disorders, and 212 parents without developmental disabilities) participated in the study. The Polish version of the PSI III was characterized by: (1) good internal consistency, (2) a three-factor structure, including Parent domain, Child domain, and the children’s and parents’ difficulties in adapting to the external demands resulting from the children’s developmental disorder, and (3) negative correlations between parental stress and parental well-being. Implications for the research and clinical practice are discussed.
An automated methodology to select functional co-simulation configurations
Authors: Rahikainen Jarkko , González Francisco , Naya Miguel Ángel 
Published: September 2019

Abstract
The development of machinery often requires system-level analysis, in which non-mechanical subsystems, such as hydraulics, need to be considered. Co-simulation allows analysts to divide a problem into subsystems and use tailored software solutions to deal individually with their respective dynamics. On the other hand, these subsystems must be coupled at particular instants in time, called communication points, through the exchange of coupling variables. Between communication points, each subsystem solver carries out the integration of its states without interacting with its environment. This may cause the integration to become unstable, especially when non-iterative co-simulation is used. The co-simulation configuration, i.e., the parameters and simulation options selected by the analyst, such as the way to handle the coupling variables or the choice of subsystem solvers, is often a critical factor regarding co-simulation stability. In practice it is difficult to anticipate which selection is the most appropriate for a particular problem, especially if some inputs come from external sources, such as human operators, and cannot be determined beforehand. We put forward a methodology to automatically determine a stable and computationally efficient configuration for Jacobi-scheme co-simulation. The method uses energy residuals to gain insight into co-simulation stability. The relation between energy residual and communication step-size is exploited to monitor co-simulation accuracy during a series of tests in which the external inputs are replaced with predetermined input functions. The method was tested with hydraulically actuated mechanical examples. Results indicate that the proposed method can be used to find stable and accurate configurations for co-simulation applications.
Enhancing capacity of optical links using polarization multiplexing
Authors: Badraoui Nada , Berceli Tibor 
Published: September 2019

Abstract
5G mobile networks targets wireless connection capacity up to 10 Gb/s. For this purpose, we propose a method to considerably increase capacity. In this paper first, we show how to compensate the effects of polarization mode dispersion (PMD) in systems with double polarizations where PMD in such systems could cause fluctuations in optical transmission due to crosstalk and cross phase modulation. Second, we show how to enhance system capacity benefiting from polarization multiplexing (POL-MUX) technique which can provide double bandwidth efficiency. Based on the simulation results, we have achieved optimum system performance and we were able to reduce the PMD effect using pre- and post-compensation. We also have improved the POL-MUX technique using coherent detection in case of 16/64 QAM modulations. The results were achieved by implementing polarization controllers, polarization beam combiners and splitters, as well as polarization phase shifters.
Personality types and subjective well-being among people living with HIV: a latent profile analysis
Authors: Rzeszutek Marcin , Gruszczyńska Ewa 
Published: September 2019

Abstract

Purpose
We examined whether three types of personality (i.e. resilient, undercontrolled and overcontrolled) based on the Big Five personality taxonomy could be replicated among people living with HIV (PLWH). We also aimed to establish significant sociodemographic and clinical covariates of profile membership and verify whether these profiles are related to the subjective well-being (SWB) of participants.

Methods
770 PLWH participated in this study. The Big Five personality traits were evaluated with the NEO-FFI questionnaire. SWB was operationalised by satisfaction with life (Satisfaction with Life Scale) and positive and negative affects (PANAS-X). Moreover, sociodemographic and clinical variables were collected.

Results
Latent profile analysis was used to identify personality types among participants. Instead of the three profiles most frequently reported in the literature, we identified a four-profile model (the resilient, undercontrolled, overcontrolled and the average profile type) as the best fit to the data. These profiles did not differ with regard to sociodemographic and clinical covariates. However, significant differences in SWB across profiles were noted, i.e. the highest SWB was observed among members of the resilient profile, and overcontrollers and undercontrollers were almost equally regarded as second best in SWB level, whereas the average profile consists of PLWH with the worst SWB.

Conclusion
Identifying personality types in clinical settings enables more comprehensive understanding of interrelations between personality and health. Regarding PLWH, the typological approach may shed new light on ambiguous results devoted to the role of personality in well-being of these patients.