bluuebunny/crossref_metadata_2025_split huggingface dataset:
Does Component Alignment Affect Patient Reported Outcomes following Bicruciate Retaining Total Knee Arthroplasty? An In Vivo Three-Dimensional Analysis
Authors: Peng Yun , Arauz Paul , An Shuai , Limmahakhun Sakkadech , Klemt Christian , Kwon Young-Min 
Published: May 2019

AbstractThis is an experimental study. Anterior cruciate ligament (ACL) and posterior cruciate ligament (PCL) retaining bicruciate retaining (BCR) total knee arthroplasty (TKA) have the potential to restore normal knee kinematics and thus improve patient outcome. Limited studies have examined the relationship between component alignment and patient-reported outcome measures (PROM). This study aims to determine (1) accurate three-dimensional (3D) component alignment of BCR TKA and (2) whether the component alignment of BCR TKA affects PROMs. The 3D modeling analysis was performed based on computed tomography images from 29 BCR TKAs. Component orientations were quantified for femoral and tibial components in the sagittal, axial, and coronal planes. The knee society scores (KSS) were collected preoperatively and postoperatively at 1-year follow-up. Multiple comparisons were performed to analyze the relationship between component alignment and patient outcomes. High variability was observed in the tibial component alignment (root–mean-square values: axial plane 6.6 degrees, sagittal plane 5.1 degrees, and coronal plane 4.0 degrees). At 1-year follow-up, significant improvement in KSS was noted in BCR TKA patients (p < 0.001). However, regression analysis adjusting for baseline KSS demonstrated the postoperative KSS was negatively associated with the posterior tibial slope (B [slope of the output of the regression analysis] = 2.597, p = 0.006). Patients with greater posterior tibial slopes were reported poorer postoperative functions at 1-year follow-up. Excessive posterior tibial slope may generate greater posterior force on the femur that leads to continuous overloading of the preserved ACL, suggesting optimal sagittal plane alignment of the tibial component may be important for the optimization of postoperative functions of BCR TKA patients.
FAM64A positively regulates STAT3 activity to promote Th17 differentiation and colitis-associated carcinogenesis
Authors: Xu Zhi-Sheng , Zhang Hong-Xia , Li Wei-Wei , Ran Yong , Liu Tian-Tian , Xiong Mei-Guang , Li Qing-Lan , Wang Su-Yun , Wu Min , Shu Hong-Bing , Xia Huimin , Wang Yan-Yi 
Published: May 2019

Significance
The transcription factor STAT3 plays pivotal roles in various physiological processes, including differentiation of Th cells. Its deregulation results in serious diseases, including inflammatory diseases and cancer. Understanding how STAT3 activity is regulated is important for deciphering the pathogenesis of such diseases. In this study, we identified a protein called FAM64A, which promotes STAT3 activity through modulating the DNA-binding activity of STAT3. Consequently, FAM64A also promotes Th17 differentiation and development of colitis and colitis-associated cancer. This study reveals a previously unreported function of FAM64A in the regulation of inflammation and tumorigenesis and provides a potential therapeutic target for inflammatory diseases and cancer.
Second-order induction in prediction problems
Authors: Argenziano Rossella , Gilboa Itzhak 
Published: May 2019

Significance
How do people generate beliefs about economic, political, and social events? A natural formula for the predicted value of a variable is its weighted average value in the past, where past values are given a higher weight if they were observed in circumstances more similar to the current ones. Agents learn from the data the best way to assess the similarity of past cases to the present one. The basic formula and this learning process appeared both in statistics and in psychology and they thus make sense for modeling economic agents. We study this process and identify circumstances under which agents are likely to agree on predictions and conditions under which disagreement over predictions may be reasonably expected.
Femtosecond laser-heating effect on the magnetization dynamics in perpendicularly magnetized Ta/CoFeB/MgO film
Authors: Liu Bo , Yang Long , Ruan Xuezhong , Cai Jian-Wang , He Liang , Meng Hao , Wu Jing , Xu Yongbing 
Published: May 2019

Abstract
We have studied the effect of ultrafast laser-heating on the magnetization dynamics of perpendicularly magnetized CoFeB film by means of the time-resolved magneto-optical Kerr rotation effect. The effective perpendicular magnetic anisotropy field

H

K

is significantly decreased with enhancing the pump laser-fluence in a moderate range of 5–12 mJ cm−2. The Gilbert damping, however, is found to be independent of the pump fluence. These findings provide a new method of separately manipulating the Gilbert damping and perpendicular magnetic anisotropy.
A Preliminary Study for Simple Physics Models of Coconut Tree
Authors: Rahmawati  , Rahmayanti HD , Amalia N , Utami FD , Viridi S , Abdullah M 
Published: May 2019

AbstractAn investigation of how coconut palm tree withstands gale force winds has been performed. When observed carefully, the motion of the stalks and leaves affected the wind resistance. The stalks and leaves move randomly when the wind blows continously. Although this is such an interesting phenomenon, there is still no report on the physical modelling. This paper proposes a simple mathematical model to analyze the phenomenon. A simple tool was also designed to retrieve data usingVideo Tracker. The experiments were conducted on several types of springs. The model showed that the theoretical prediction accurately explained the phenomenon.
To mathematical modeling of deformation of micropolar thin bodies with two small sizes
Authors: Nikabadze M , Ulukhanyan A , Sakhvadze G 
Published: May 2019

Abstract
We consider some problems of modeling the deformation of micropolar thin bodies with two small sizes. Using the three-dimensional equations of motion, the constitutive relations and the boundary conditions of the micropolar elasticity theory [1, 2], we got the equations of motion, the constitutive relations and the boundary conditions of the micropolar theory of thin bodies under the parametrization of the thin body domain with two small sizes [3]. The boundary conditions and various representations of the system of equations of motion and the constitutive relations of physical content in moments with respect to the Legendre polynomials are obtained. Note that using this method of construction the thin bodies theory with two small sizes, we get an infinite system of ordinary differential equations. This system contains quantities which depends on one variable, namely, depends on the parameter of the base line. Thus, decreasing the number of independent variables from three to one we increase the number of equations to infinity, which, of course, has its obvious practical inconveniences. In this regard, we reduce an infinite system to the finite system. The initial-boundary value problems are formulated. To satisfy the boundary conditions on the front surfaces we constructed correcting terms [4]. As a special case, we considered a prismatic body. We used the tensor calculus to do this research [5–8].
Genetic Testing in the Diagnosis and Biology of Myeloid Neoplasms (Excluding Acute Leukemias)
Authors: Hasserjian Robert P , Kelley Todd W , Weinberg Olga K , Morgan Elizabeth A , Fend Falko 
Published: May 2019

AbstractObjectivesThe 2017 Workshop of the Society for Hematopathology/European Association for Haematopathology reviewed the role of genetic testing in the diagnosis of hematopoietic neoplasms, including non–acute leukemia myeloid malignancies.MethodsThe workshop panel assigned 98 submitted cases to the category of non–acute leukemia myeloid neoplasms, of which 13 were selected for oral presentation.ResultsData from both conventional karyotyping and genetic sequencing had important impact on diagnosis, classification, and prognostication. However, some cases had genetic results that appeared discordant from the morphology and/or clinical features. Thus, the workshop underscored the need for careful management of genetic data by the pathologist and clinician, in the context of other findings.ConclusionsThe workshop cases highlighted the significance of genetic aberrations in the diagnosis and treatment of non–acute leukemia myeloid neoplasms. Many genetic data have already been incorporated in the most recent World Health Organization classification, and undoubtedly they will factor increasingly in future classifications.
Stress-Induced Sensitization of Angiotensin II Hypertension Is Reversed by Blockade of Angiotensin-Converting Enzyme or Tumor Necrosis Factor-α
Authors: Xue Baojian , Yu Yang , Wei Shun-Guang , Beltz Terry G , Guo Fang , Felder Robert B , Johnson Alan Kim 
Published: May 2019

Abstract

BACKGROUND
Post-traumatic stress disorder (PTSD) is characterized by a disordered stress response and associated with increased cardiovascular disease risk. The present study investigated whether angiotensin (Ang) II-elicited hypertensive response is sensitized in a model of PTSD and whether inhibition of angiotensin-converting enzyme (ACE) or tumor necrosis factor (TNF)-α prior to PTSD blocks this sensitization of Ang II hypertension.

METHODS
The resident–intruder paradigm was used to model PTSD. Each intruder rat (male Sprague-Dawley) was given normal drinking water or was pretreated with either an ACE inhibitor (captopril) or a TNF-α inhibitor (pentoxifylline) in the drinking water for 2 weeks. Subsequently, they were exposed to a different resident (male Long-Evans) for 2 hours on 3 days with each session separated by 1 day and then received a subcutaneous infusion of Ang II for 2 weeks.

RESULTS
The stressed rats had a significantly enhanced hypertensive response to the Ang II infusion (stressed Δ40.2 ± 3.9 mm Hg vs. unstressed Δ20.5 ± 4.5 mm Hg) and an upregulation of mRNA or protein expression of renin–angiotensin system (RAS) and proinflammatory cytokine (PIC) components and of a microglial marker in the lamina terminalis and hypothalamic paraventricular nucleus when compared with unstressed control rats. Both the sensitized hypertensive response and enhanced gene and protein expression were blocked by pretreatment with either ACE (Δ21.3 ± 3.9 mm Hg) or TNF-α inhibitor (Δ21.4 ± 2.6 mm Hg).

CONCLUSIONS
The results indicate that upregulation of the brain RAS and PICs produced by severe stress contributes to traumatic-induced sensitization of hypertensive response to Ang II, and disorders such as PTSD may predispose individuals to development of hypertension.
Oviposition Preference and Larval Performance of Drosophila suzukii (Diptera: Drosophilidae), Spotted-Wing Drosophila: Effects of Fruit Identity and Composition
Authors: Olazcuaga Laure , Rode Nicolas O , Foucaud Julien , Facon Benoit , Ravigné Virginie , Ausset Aurélien , Leménager Nicolas , Loiseau Anne , Gautier Mathieu , Estoup Arnaud , Hufbauer Ruth A 
Published: May 2019

Abstract
A better understanding of the factors affecting host plant use by spotted-wing drosophila (Drosophila suzukii) could aid in the development of efficient management tools and practices to control this pest. Here, proxies of both preference (maternal oviposition behavior) and performance (adult emergence) were evaluated for 12 different fruits in the form of purees. The effect of the chemical composition of the fruits on preference and performance traits was then estimated. We synthesized the literature to interpret our findings in the light of previous studies that measured oviposition preference and larval performance of D. suzukii. We show that fruit identity influences different parts of the life cycle, including oviposition preference under both choice and no-choice conditions, emergence rate, development time, and number of emerging adults. Blackcurrant was always among the most preferred fruit we used, while grape and tomato were the least preferred fruits. Larvae performed better in cranberry, raspberry, strawberry, and cherry than in the other fruits tested. We found that fruit chemical compounds can explain part of the effect of fruit on D. suzukii traits. In particular, oviposition preference under choice conditions was strongly influenced by fruit phosphorus content. In general, the consensus across studies is that raspberry, blackberry, and strawberry are among the best hosts while blackcurrant, grape and rose hips are poor hosts. Our results generally confirm this view but also suggest that oviposition preferences do not necessarily match larval performances. We discuss opportunities to use our results to develop new approaches for pest management.
Alternative Retirement Paths and Cognitive Performance: Exploring the Role of Preretirement Job Complexity
Authors: Carr Dawn C , Willis Robert , Kail Ben Lennox , Carstensen Laura L 
Published: May 2019

Abstract

Background and Objectives
Recent research suggests that working longer may be protective of cognitive functioning in later life, especially for workers in low complexity jobs. As postretirement work becomes increasingly popular, it is important to understand how various retirement pathways influence cognitive function. The present study examines cognitive changes as a function of job complexity in the context of different types of retirement transitions.

Research Design and Methods
We use data from the Health and Retirement Study (HRS) to examine change in cognitive function for workers who have held low, moderate, and high complexity jobs and move through distinct retirement pathways—retiring and returning to work, partial retirement—compared with those who fully retire or remain full-time workers. Inverse probability weighted regression adjustment (a propensity score method) is used to adjust for selection effects.

Results
There are systematic variations in the relationships between work and cognitive performance as a function of job complexity and retirement pathways. All retirement pathways were associated with accelerated cognitive decline for workers in low complexity jobs. In contrast, for high complexity workers retirement was not associated with accelerated cognitive decline and retiring and returning to work was associated with modest improvement in cognitive functioning.

Discussion and Implications
Both policy makers and individuals are beginning to embrace longer working lives which offer variety of potential benefits. Our findings suggest that continued full-time work also may be protective for cognitive health in workers who hold low complexity jobs.
Persistence and Lethality of a Fungal Biopesticide (Aprehend) Applied to Insecticide-impregnated and Encasement-type Box Spring Covers for Bed Bug Management
Authors: Shikano Ikkei , Gomez Lauren , Bellicanta Giovani S , Jenkins Nina E 
Published: May 2019

Abstract
The newly developed fungal biopesticide Aprehend, containing spores of Beauveria bassiana, is the first biological control agent to be incorporated into management programs to control the common bed bug (Cimex lectularius L.) (Hemiptera: Cimicidae). Aprehend is sprayed as barriers where bed bugs are likely to walk and pick up spores as they search for a bloodmeal. A key application target for Aprehend is the box spring, which may be covered by encasement-type or insecticide-impregnated covers. Since some insecticides can reduce the persistence of fungal spores, we tested the efficacy and spore germination percentages of Aprehend when applied to the two types of box spring covers. We found that spore germination was about 11% lower on the permethrin-impregnated ActiveGuard cover than on the encasement-type AllerEase cover. However, bed bugs exposed for 15 min to Aprehend on the two box spring covers suffered similarly high levels of mortality irrespective of the cover material. Thus, there was no inhibitory or additive effect of the ActiveGuard cover on bed bug mortality. Lastly, overall mortality was higher if bed bugs were exposed to Aprehend-treated ActiveGuard than the ActiveGuard cover alone. Our findings indicate that if pest managers are using ActiveGuard covers in combination with Aprehend, best practice would be to use ActiveGuard on mattresses and apply Aprehend directly to the box spring or to a box spring covered by an encasement-type cover.
Evaluation of Appropriate Reference Genes For Investigating Gene Expression in Chlorops oryzae (Diptera: Chloropidae)
Authors: Tian Ping , Qiu Lin , Zhou Ailin , Chen Guo , He Hualiang , Ding Wenbing , Li Youzhi 
Published: May 2019

Abstract
Reverse transcription quantitative polymerase chain reaction (PCR) has become an invaluable technique for analyzing gene expression in many insects. However, this approach requires the use of stable reference genes to normalize the data. Chlorops oryzae causes significant economic damage to rice crops throughout Asia. The lack of suitable reference genes has hindered research on the molecular mechanisms underlying many physiological processes of this species. In this study, we used quantitative real-time PCR to evaluate the expression of eight C. oryzae housekeeping genes glyceraldehyde-3-phosphate dehydrogenase (GAPDH), β-actin (βACT), beta-tubulin (βTUB), Delta Elongation factor-1 (EF1δ), ribosomal protein S11 (RPS11), RPS15, C-terminal-Binding Protein (CtBP), and ribosomal protein 49 (RP49) in different developmental stages and tissues in both larvae and adults. We analyzed the data with four different software packages: geNorm, NormFinder, BestKeeper, and RefFinder and compared the results obtained with each method. The results indicate that PRS15 and RP49 can be used as stable reference genes for quantifying gene expression in different developmental stages and larval tissues. GAPDH and βACT, which have been considered stable reference genes by previous studies, were the least stable of the candidate genes with respect to larval tissues. GAPDH was, however, the most stable reference gene for adult tissues. We verified the candidate reference genes identified and found that the expression levels of Cadherins (Cads) changed when different reference genes were used to normalize gene expression. This study provides a valuable foundation for future research on gene function, and investigating the molecular basis of physiological processes, in C. oryzae.
Implications of forest management practices for sex-specific habitat use by Nycticeius humeralis
Authors: Kwon Youngsang , Doty Anna C , Huffman Megan L , Rolland Virginie , Istvanko Daniel R , Risch Thomas S 
Published: May 2019

AbstractNorth American bats are experiencing declines in part due to anthropogenic impacts resulting in habitat loss and disturbance. In eastern deciduous forests, bats rely on forest resources for all or part of the year. Therefore, to promote conservation of bats, it is essential to determine whether current forest management techniques are compatible with habitat use by bats. We evaluated the relative effect of landscape characteristics, including forest management variables, on sex-specific foraging habitat of an insectivorous forest-dwelling bat species, the evening bat (Nycticeius humeralis), and predicted areas of suitable habitat for N. humeralis. A total of 18 variables were assessed using a maximum-entropy (Maxent) machine-learning approach: eight land use–land cover classes, three stand types, two topography measures, normalized difference vegetation index, and four forest management variables. Females showed the highest probability of presence closer to stands treated with prescribed fire, whereas males showed the highest probability of presence closer to reforested stands. In general, males exhibited more flexibility than females in their habitat selection. The Maxent model further indicated that habitat associated with suitability of > 70% was ~4 times larger for males than females, and predicted an additional area of suitable foraging habitat where no presence locations had been recorded. Our modeling approach may be suitable for other researchers to derive models appropriate for a wide range of bat species.
See how they ran: morphological and functional aspects of skeletons from ancient Egyptian shrew mummies (Eulipotyphla: Soricidae: Crocidurinae)
Authors: Woodman Neal , Wilken Alec T , Ikram Salima 
Published: May 2019

Abstract
Animals served important roles in the religious cults that proliferated during the Late (ca. 747–332 BCE) and Greco-Roman Periods (332 BCE–CE 337) of ancient Egypt. One result was the interment of animal mummies in specialized necropolises distributed throughout the country. Excavation of a rock-tomb that was re-used during the Ptolemaic Period (ca. 309–30 BCE) for the interment of animal mummies at the Djehuty Site (TT 11–12) near Luxor, Egypt, was carried out in early 2018 by a Spanish–Egyptian team sponsored by the Consejo Superior de Investigaciones Científicas, Madrid. The tomb burned sometime after deposition of the mummies, leaving behind abundant disassociated skeletal remains, primarily of avians, but also including two species of shrews (Soricidae): Crocidura olivieri and C. religiosa. To investigate possible intraspecific variation in morphology and locomotor function in these two species during the last two millennia, we measured morphological features of individual postcranial bones from the two archaeological samples and calculated indices that have been used to assess locomotor function. We compared the measurements to those from modern C. olivieri, C. religiosa, and C. suaveolens using principal components analysis, and we compared locomotor indices to those we calculated for the three modern species of Crocidura and to those from nine species of myosoricine shrews. Osteological features of the postcranial skeleton of conspecific Ptolemaic and modern samples of C. olivieri and C. religiosa are generally similar in character and proportion, and, skeletally, these shrews and modern C. suaveolens are consistent with soricids having a primarily ambulatory locomotor mode. One exception is the deltopectoral crest of the humerus, which appears to be longer in modern C. religiosa. Despite general conservation of form and function, Ptolemaic C. olivieri had larger body size than modern Egyptian populations and were more similar in size to modern C. olivieri nyansae from Kenya than to modern C. olivieri olivieri from Egypt.
Protein Melting Temperature Cannot Fully Assess Whether Protein Folding Free Energy Underlies the Universal Abundance–Evolutionary Rate Correlation Seen in Proteins
Authors: Razban Rostam M 
Published: May 2019

AbstractThe protein misfolding avoidance hypothesis explains the universal negative correlation between protein abundance and sequence evolutionary rate across the proteome by identifying protein folding free energy (ΔG) as the confounding variable. Abundant proteins resist toxic misfolding events by being more stable, and more stable proteins evolve slower because their mutations are more destabilizing. Direct supporting evidence consists only of computer simulations. A study taking advantage of a recent experimental breakthrough in measuring protein stability proteome-wide through melting temperature (Tm) (Leuenberger et al. 2017), found weak misfolding avoidance hypothesis support for the Escherichia coli proteome, and no support for the Saccharomyces cerevisiae, Homo sapiens, and Thermus thermophilus proteomes (Plata and Vitkup 2018). I find that the nontrivial relationship between Tm and ΔG and inaccuracy in Tm measurements by Leuenberger et al. 2017 can be responsible for not observing strong positive abundance–Tm and strong negative Tm–evolutionary rate correlations.