bluuebunny/crossref_metadata_2025_split huggingface dataset:
A systematic review of mobile health interventions in China: Identifying gaps in care
Authors: Yang Xiaoshi , Kovarik Carrie L 
Published: July 2019

Introduction Mobile health has a promising future in the healthcare system in most developed countries. China’s rapidly developing mobile technology infrastructure offers an unprecedented opportunity for wide adoption of mobile health interventions in the delivery of effective and timely healthcare services. However, there is little data on the current extent of the mobile health landscape in China. The aim of this study was to systematically review the existing mobile health initiatives in China, characterise the technology used, disease categories targeted, location of the end user (urban versus rural), and examine the potential effects of mobile health on health system strengthening in China. Furthermore, we identified gaps in development and evaluation of the effectiveness of mobile health interventions. Methods A systematic review of the literature published from 18 December 2015 – 3 April 2019 was conducted and yielded 2863 articles from English and Chinese retrieval database and trial registries, including PubMed, EMBASE, China National Knowledge of Infrastructure and World Health Organization International Clinical Trials Registry Platform. Studies were included if they used mobile health to support patient healthcare outcomes. Results A total of 1129 full-text articles were assessed and 338 were included in this study. The review found that most studies targeted client education and behaviour change via applications (apps) (65.4%), including WeChat, and text messaging (short text messages) (19.8%) to improve patient medical treatment outcomes such as compliance and appointment reminders. The most common disease-specific mobile health interventions focused primarily on chronic disease management and behaviour change in cardiology (13.3%), endocrinology/diabetes (12.1%), behavioural health (11.8%), oncology (11.2%) and neurology (6.8%). The mobile health interventions related to nutrition (0.6%) and chronic respiratory diseases (1.6%) are underrepresented in mobile health in comparison to the burden of disease in China. The majority (90.0%) of the mobile health interventions were conducted exclusively in urban areas, with few opportunities reaching rural populations. Conclusions Overall, mobile health has a promising future in China, with recent rapid growth in initiatives. The majority are focused on education and behaviour change in the realm of chronic diseases and target patients in urban areas. The imbalance in mobile health between the urban and rural areas, as well as between population disease spectrum and health service delivery, pose substantial dilemmas. However, mobile health may be redirected to correct this imbalance, possibly improving access to healthcare services, and filling the gaps in order to improve health equity for the underserved populations in China.
Decreased Levels of Serum IGF-1 and Vitamin D Are Associated With Cognitive Impairment in Patients With Type 2 Diabetes
Authors: Rui-hua Chen , Yong-de Peng , Xiao-zhen Jiang , Chen Jason , Bin Zhou 
Published: July 2019

Purpose: To determine the association of serum insulin-like growth factor 1 (IGF-1) and vitamin D levels with cognition status in patients with type 2 diabetes mellitus (T2DM). Methods: A total of 173 patients with T2DM were recruited and divided into mild cognitive impairment (MCI) group (n = 94) and normal cognition (NC) group (n = 79). Levels of IGF-1 and 25(OH)D were measured and compared, and the correlations among IGF-1, 25(OH)D, and cognitive function were analyzed. Results: Insulin-like growth factor 1 and 25(OH)D levels significantly decreased in MCI group than those in the NC group (both P < .001). Multiple stepwise regression analysis revealed that IGF-1 (β = .146, P < .001) and 25(OH)D (β = .199, P < .001) independently predicted Montreal Cognitive Assessment (MoCA) scores. Partial least square regression showed that contributions of both 25(OH)D ( P < .001) and IGF-1 ( P < .001) to MoCA scores were significant, while no cross-effect was observed between them ( P = .714). Conclusions: Low serum IGF-1 and 25(OH)D levels may separately predict poor cognitive performance in patients with diabetes.
Drug therapy problems among patients with cardiovascular disease admitted to the medical ward and had a follow-up at the ambulatory clinic of Hiwot Fana Specialized University Hospital: The case of a tertiary hospital in eastern Ethiopia
Authors: Gelchu Tamene , Abdela Jemal 
Published: July 2019

Background: Pharmacotherapy is important in reducing morbidity and mortality related to cardiovascular diseases. However, these advantages are limited by drug therapy problems that can impact on a patient’s quality of life, prolong hospital stays, and increase the overall burden of healthcare expenditures. Therefore, this study was aimed to assess drug therapy problems among patients with cardiovascular diseases who were hospitalized and received follow-up at the ambulatory clinic of Hiwot Fana Specialized University Hospital. Methods: An institution-based cross-sectional study design was used to collect data from patients with cardiovascular diseases who were admitted to the medical ward and those who had received follow-up at the ambulatory clinic of Hiwot Fana Specialized University Hospital. The collected data were coded, entered, and analyzed using SPSS version 16. The associations of selected categorical variables were done using binary logistic and multivariate logistic regression analyses. Results: Out of 216 study participants, females accounted for 123 (57%), whereas 93 (43%) of them were males. Among cardiovascular diseases identified in the medical ward and ambulatory clinics of Hiwot Fana Specialized University Hospital, congestive heart failure 96 (44.4%) and hypertension 93 (43.1%) were the two most commonly diagnosed disorders. Of the total participants involved in the study, 131 (60.65%) had drug therapy problems. Among the seven classes of drug therapy problems assessed, the most commonly observed was the need for additional drug therapy 76 (58%); followed by cases related to unnecessary drug therapy and noncompliance both of which were estimated to be 16 (12.2%). In addition, of independent variables, only the use of more than three drugs was significantly associated in both binary logistic (crude odds ratio = 0.41, 95% confidence interval = 0.234–0.719, p = 0.002) and multivariate logistic regressions (adjusted odds ratio = 4.86, 95% confidence interval = 1.625–14.536, p = 0.005) as compared with those patients who were using less than three drugs. Conclusion: The findings of the study indicated that more than half of the study participants experienced drug therapy problems, for which 58% required additional drug therapy. The risk of drug therapy problem is found to increase with the use of more than three drugs. Since these problems are adversely affecting the treatment outcome of patients, this is an area which requires special attention and the cooperation of healthcare professionals to tackle it.
Case Report: Penile necrosis associated to paraphimosis with calciphylaxis due to terminal chronic kidney disease
Authors: Grandez-Urbina J. Antonio , Corrales-Acosta Elizabeth , Tejeda-Mariaca J. Eduardo , Pichardo-Rodriguez Rafael , Garcia-Perdomo Herney 
Published: July 2019

Background: Penile necrosis is a rare condition that may present in patients with diabetes mellitus or chronic kidney disease (CKD). The recommended treatment is controversial. We report a case of penile necrosis in a diabetic patient caused by episode of paraphimosis associated with uremic arteriopathy treated with partial amputation. Clinical Case: A 53-year-old male with a background of arterial hypertension, diabetes mellitus and CKD in hemodialysis. The patient presented with paraphimosis and glans necrosis. An emergency circumcision was carried out. A doppler ultrasound found fluid collection in the left corpus cavernosum, parietal vascular calcifications and vascular insufficiency in the corpus cavernosum that suggested necrosis. A partial amputation of the penis was carried out. After three years of follow-up, the outcome has remained favorable. Conclusions: Penile necrosis is a rare but serious complication of terminal CKD. In these patients, systemic calciphylaxis is usually observed. The main take-away lesson is that a multidisciplinary approach is necessary.
Iron Hack - A symposium/hackathon focused on porphyrias, Friedreich’s ataxia, and other rare iron-related diseases
Authors: Ferreira Gloria C. , Oberstaller Jenna , Fonseca Renée , Keller Thomas E. , Adapa Swamy Rakesh , Gibbons Justin , Wang Chengqi , Liu Xiaoming , Li Chang , Pham Minh , Dayhoff II Guy W. , Duong Linh M. , Reyes Luis Tañón , Laratelli Luciano Enrique , Franz Douglas , Fatumo Segun , Bari ATM Golam , Freischel Audrey , Fiedler Lindsey , Dokur Omkar , Sharma Krishna , Cragun Deborah , Busby Ben , Jiang Rays H.Y. 
Published: July 2019

Background: Basic and clinical scientific research at the University of South Florida (USF) have intersected to support a multi-faceted approach around a common focus on rare iron-related diseases. We proposed a modified version of the National Center for Biotechnology Information’s (NCBI) Hackathon-model to take full advantage of local expertise in building “Iron Hack”, a rare disease-focused hackathon. As the collaborative, problem-solving nature of hackathons tends to attract participants of highly-diverse backgrounds, organizers facilitated a symposium on rare iron-related diseases, specifically porphyrias and Friedreich’s ataxia, pitched at general audiences. Methods: The hackathon was structured to begin each day with presentations by expert clinicians, genetic counselors, researchers focused on molecular and cellular biology, public health/global health, genetics/genomics, computational biology, bioinformatics, biomolecular science, bioengineering, and computer science, as well as guest speakers from the American Porphyria Foundation (APF) and Friedreich’s Ataxia Research Alliance (FARA) to inform participants as to the human impact of these diseases. Results: As a result of this hackathon, we developed resources that are relevant not only to these specific disease-models, but also to other rare diseases and general bioinformatics problems. Within two and a half days, “Iron Hack” participants successfully built collaborative projects to visualize data, build databases, improve rare disease diagnosis, and study rare-disease inheritance. Conclusions: The purpose of this manuscript is to demonstrate the utility of a hackathon model to generate prototypes of generalizable tools for a given disease and train clinicians and data scientists to interact more effectively.
Economic Analysis: Trickling Filter/Activated Sludge or Nitrifying Trickling Filter/Activated Sludge?
Authors: Jafarinejad Shahryar 
Published: July 2019

Abstract
The performance and economic simulation and modeling are crucial for accurate and rapid designing, construction, and forecasting future economic needs of municipal wastewater treatment plants (MWWTPs). In this study, combined nitrifying trickling filter/activated sludge (NTF/AS) process was suggested for the modernization of a MWWTP and the performance and economics of MWWTPs based on the combined TF/AS process and combined NTF/AS process were analyzed and compared. In real, the performance, total project construction, total operation labor, total maintenance labor, total material, total chemical, total energy, and total amortization costs of these proposed MWWTPs were calculated and compared. Under the used design criteria and operational conditions in this study, the project construction cost of the MWWTP based on TF/AS was 15.25 % higher than that of the MWWTP based on NTF/AS. Also, MWWTP based on NTF/AS was cost effective and the material and amortization costs for both plants were higher in comparison with the operation, maintenance, energy, and chemical costs. It is necessary to note that this study is a computer simulation for a case and drawing general conclusions only on the basis of this simulation may be insufficient.
Physicochemical and Antimicrobial Properties of Hydroxypropyl Methylcellulose-Cinnamon Essential Oil Emulsion: Effects of Micro- and Nanodroplets
Authors: Li Shuzhi , Zhou Jingyang , Wang Yanan , Teng Anguo , Zhang Kai , Wu Zinan , Cheng Shan , Wang Wenhang 
Published: July 2019

Abstract
Emulsion is an efficient encapsulation tool for enhancing the functional properties of essential oils (EOs). Herein, two two-dimensional cinnamon essential oil emulsions (from micro- to nanoscales) were emulsified by hydroxypropyl methylcellulose, and their antimicrobial and physicochemical properties were investigated. For the models of Escherichia coli CGMCC 1.0907, Salmonella enterica subsp. Enterica serovar Typhi (CICC 10867), Staphylococcus aureus CGMCC 1.0089, and Listeria monocytogene CGMCC 1.9144, the minimum inhibitory concentration (MIC) of the nanoemulsion was 31.25 μL/mL compared to that of the microemulsion (62.5–125 μL/mL) and pure oil (125–250 μL/mL), indicating the superiority of nanoemulsion as an antibacterial agent. The results showed that the highest activity was seen in the gram-positive L. monocytogenes whereas the lowest was in the gram-negative S. enterica. The identified properties of HPMC (hydroxypropyl methylcellulose) provide the potential for emulsifying and enhancing essential oils in light industries, especially for food processing.
Comparison and assessment of zeolite catalysts performance dimethyl ether and light olefins production through methanol: a review
Authors: Kianfar Ehsan 
Published: July 2019

Abstract
The present review focuses on a comparison and assessment of zeolite catalyst performance of dimethyl ether and light olefin production through methanol. Dimethyl ether is a clean fuel which needs diverse processes to be produced. Methanol to dimethyl ether is a very novel process which offers considerable advantages versus additional processes for the production of dimethyl ether. The corresponding fixed-bed reactors compose the most important section of such a process. Production of dimethyl ether by the mentioned process is of high importance since it can be catalytically transferred to a substance with the value of propylene. Furthermore, in case of capability to transfer low-purity methanol into dimethyl ether, less expensive methanol can be consequently achieved with higher value added. In the petrochemical industry, light olefins, for example, ethylene and propylene, can be used as raw materials for the production of polyolefin. The present review aims to produce dimethyl ether in order to reach olefin substances, initially conducting a compressive assessment on production methods of olefin substances.
Mentoring Characteristics and Functions Important to Men and Women within Intercollegiate Athletic Administration
Authors: Bower Glenna , Hums Mary , Williams Sarah 
Published: July 2019

Female athletic administrators were asked about the role of mentoring in their careers as women while male athletic administrators were asked about the role of mentoring in their careers as men working in intercollegiate athletic administration. The researchers gathered and compared information on mentor characteristics as well as career and psychosocial benefits of having a mentor. Participants were 518 female and 778 male athletic administrators working at NCAA Division I, II, and IIII, NAIA, NCCAA, and NJCAA schools. A three-step content-analytic procedure was used to analyze the qualitative data.
Men identified being trustworthy, supportive, respected, and a good listener while women identified being supportive, hardworking, and knowledgeable as the most important mentor characteristics. Men most frequently named coaching and challenging assignments as career benefits from mentors while women named exposure/visability and coaching. Both men and women most frequently identified counseling and role modeling as psychosocial benefits from mentors.
SERAPAN KARBON LAMUN Thalassia hemprichii PADA BEBERAPA KEDALAMAN
Authors: Mashoreng Supriadi , Alprianti Sheryl , Samad Wasir , Isyrini Rantih , Inaku Dwi Fajriati 
Published: July 2019

Ekosistem padang lamun merupakan ekosistem yang umum ditemukan di Kepulauan Spermonde, salah satunya adalah Gusung Bonebatang. Lamun mempunyai kemampuan menyerap karbon untuk proses fotosintesis sehingga berpotensi dalam mitigasi perubahan iklim. Penelitian dilakukan pada bulan Agustus 2017 untuk membandingkan penyerapan karbon oleh jenis Thalassia hemprichii pada beberapa kedalaman perairan. Sampel lamun diambil pada daerah subtidal, kemudian daun lamun dibersihkan dari sedimen dan epifit. Metode perubahan oksigen digunakan untuk mengestimasi serapan karbon. Sebanyak 1 tunas T. hemprichii diinkubasi menggunakan botol kaca bening 70 ml. Inkubasi dilakukan pada jam 09.00-12.00 WITA pada kedalaman 50, 100, 150, 200 dan 250 cm dengan masing-masing 5 kali ulangan setiap kedalaman. Sebelum inkubasi, dilakukan pengukuran konsentrasi oksigen terlarut di perairan sebagai kandungan oksigen awal. Pengukuran oksigen di dalam botol bening kembali dilakukan setelah inkubasi. Selain oksigen terlarut, dilakukan juga pengukuran konsentrasi bikarbonat pada awal dan akhir inkubasi. Sebagai kontrol, inkubasi juga dilakukan pada air laut (mengandung fitoplankton) dengan 5 kali ulangan. Daun lamun yang telah digunakan untuk pengamatan serapan karbon diukur luasnya dengan cara men-scan daun lamun dan dianalisis menggunakan software Imaje-J. Selanjutnya dilakukan pengeringan menggunakan oven dan ditimbang untuk mengetahui biomassa keringnya. Hasil penelitian menunjukkan bahwa serapan karbon per tunas berkisar antara 0,928-1,476 mgCO2/tunas/jam, per biomassa berkisar 10,647-25,745 mgCO2/gbk/jam, dan per luas daun berkisar 0,010-0,024 mgCO2/cm2/jam. Serapan karbon tertinggi didapatkan pada kedalaman 200 cm, baik serapan karbon per tunas, biomass maupun luas daun.
APLIKASI EDIBLE FILM MAIZENA DENGAN PENAMBAHAN EKSTRAK JAHE SEBAGAI ANTIOKSIDAN ALAMI PADA COATING SOSIS SAPI
Authors: Manuhara Godras Jati , Kawiji Kawiji , E Heny Ratri 
Published: July 2019

<p>Penambahan ekstrak jahe yang mengandung antioksidan alami ke dalam pembuatan edible coating sosis diharapkan mampu mengurangi kerusakan lemak pada produk sosis. Penelitian ini memiliki dua tujuan. Pertama, Mengetahui konsentrasi penambahan ekstrak jahe pada edible coating sosis yang paling disukai oleh panelis.<br />Kedua, mengetahui pengaruh penambahan ekstrak jahe pada edible coating sosis terhadap tingkat kerusakan lemak sosis selama penyimpanan. Berdasarkan uji yang dilakukan pada aplikasi edible coating sosis, yakni uji organoleptik, uji susut<br />berat, dan uji kerusakan oksidatif lemak, diketahui bahwa perlakuan paling baik adalah penambahan ekstrak jahe pada edible coating sosis sebesar 10%. <br />Kata Kunci: antioksidan,edible film, maizena</p>
Linkage to Hepatitis C Care After Incarceration in Jail: A Prospective, Single Arm Clinical Trial
Authors: Akiyama Matthew Jiro , Columbus Devin , MacDonald Ross , Jordan Alison O , Schwartz Jessie , Litwin Alain H , Eckhardt Benjamin , Carmody Ellie 
Published: July 2019

Abstract
Background: Hepatitis C virus (HCV) is a major public health problem in correctional settings. HCV treatment is often not possible in U.S. jails due to short lengths of stay. Linkage to care is crucial in these settings, but competing priorities complicate community healthcare engagement and retention after incarceration.

Methods: We conducted a single arm clinical trial of a combined transitional care coordination (TCC) and patient navigation intervention and assessed the linkage rate and factors associated with linkage to HCV care after incarceration.

Results: During the intervention, 84 participants returned to the community after their index incarceration. Most participants were male and Hispanic, with a history of mental illness and a mean age of 45 years. Of those who returned to the community, 26 (31%) linked to HCV care within a median of 20.5 days; 17 (20%) initiated HCV treatment, 15 (18%) completed treatment, 9 (11%) had a follow-up lab drawn to confirm sustained virologic response (SVR), and 7 (8%) had a documented SVR. Among those with follow-up labs the known SVR rate was (7/9) 78%. Expressing a preference to be linked to the participant’s existing health system, being on methadone prior to incarceration, and feeling that family or a loved one were concerned about the participant’s wellbeing were associated with linkage to HCV care. Reporting drinking alcohol to intoxication prior to incarceration was negatively associated with linkage to HCV care.

Conclusion: We demonstrate that an integrated strategy with combined TCC and patient navigation may be effective in achieving timely linkage to HCV care. Additional multicomponent interventions aimed at treatment of substance use disorders and increasing social support could lead to further improvement.
SAFE Hi-C: A Simplified, Amplification-free and Economically Efficient High-throughput Chromosome Conformation Capturing Method
Authors: Niu Longjian , Huang Yingzhang , Hou Chunhui 
Published: July 2019

Abstract
PCR amplification of Hi-C libraries introduces unusable duplicates and results in a biased representation of chromatin interactions. We present a simplified, fast, and economically efficient Hi-C library preparation procedure that generates sufficient non-amplified ligation products for deep sequencing. Comprehensive analysis of the resulting data indicates that amplification-free Hi-C preserves higher complexity of chromatin interaction and lowers sequencing depth dramatically for the same number of unique paired reads. With amplification bias avoided, our method may produce a chromatin interaction network more faithfully reflecting the real three-dimensional genomic architecture.