bluuebunny/crossref_metadata_2025_split huggingface dataset:
MicroRNA-196a is regulated by ER and is a prognostic biomarker in ER+ Breast Cancer
Authors: Milevskiy Michael J.G. , Gujral Udai , Lama Marques Carolina Del , Stone Andrew , Northwood Korinne , Burke Lez J. , Gee Julia M.W. , Nephew Kenneth , Clark Susan , Brown Melissa A. 
Published: May 2018

AbstractMicroRNAs are potent post-transcriptional regulators involved in all hallmarks of cancer. Mir-196a is transcribed from two loci and has been implicated in a wide range of developmental and pathogenic processes, with targets including Hox, Fox, Cdk inhibitors and annexins. Genetic variants and altered expression of miR196a are associated with risk and progression of multiple cancers including breast cancer, however little is known about the regulation of the genes encoding this miRNA, nor the impact of variants therein. Here we demonstrate that MIR196A displays complex and dynamic expression patterns, in part controlled by long range transcriptional regulation between promoter and enhancer elements bound by ERα. Expression of this miRNA is significantly increased in models of hormone receptor positive disease resistance. The expression of MIR196A also proves to be a robust prognostic factor for patients with advanced and post-menopausal ER+ disease. This work sheds light on the normal and abnormal regulation of MIR196A and provides a novel stratification method for therapeutically resistant breast cancer.
Impact of Chronic Total Occlusion Lesion Length onSix-month Angiographic and 2-year Clinical Outcomes
Authors: Ahn Jihun , Rha Seung-Woon , Choi ByoungGeol , Choi Se Yeon , Byun Jae Kyeong , Mashaly Ahmed , Abdelshafi Kareem , Park Yoonjee , Jang Won Young , Kim Woohyeun , Choi Jah Yeon , Park EunJin , Na Jin Oh , Choi Cheol Ung Choi , Kim EungJu Kim , Park Chang Gyu , Seo HongSeog , Oh DongJoo , Byeon JinSu , Park SangHo , Yu HyeYon 
Published: May 2018

AbstractBackgroundSuccessful chronic total occlusion (CTO) percutaneous coronary intervention (PCI) is known to be associated with improved clinical outcomes compared with failed CTO PCI. However, it is not clear whether the angiographic and clinical outcomes of long CTO lesionis different with those of short CTO lesion in the drug eluting stent (DES) era.Method sand ResultsA total of 235 consecutive patients underwent successful CTO intervention were divided into two groups according the CTO lesion length. Six-month angiographic and two-year clinical outcomes were compared between the two groups. The baseline clinical characteristics were similar between the two groups except prior PCI was more frequent in long CTO group whereas bifurcation lesion was more frequent in the short CTO group. In-hospital complications were similar between the two groups except intimal dissection was more frequent in long CTO group. Both groups had similar angiographic outcomes at 6 months and clinical outcomes up to 2 years except the incidence of repeat PCI, predominantly target vessel revascularization (TVR) was higher in long CTO group. In multivariate analysis, long CTO was an important predictor for repeat PCI (OR;4.26, CI 1.53-11.9, p=0.006).ConclusionThe safety profile, angiographic and 2-year clinical outcomes were similar between the two groups except higher incidence of repeat PCI in long CTO group despite of successful PCI with DESs.
Linked mutations at adjacent nucleotides have shaped human population differentiation and protein evolution
Authors: Prendergast James G. D. , Pugh Carys , Harris Sarah E. , Hume David A. , Deary Ian J. , Beveridge Allan 
Published: May 2018

AbstractDespite the fundamental importance of single nucleotide polymorphisms (SNPs) to human evolution there are still large gaps in our understanding of the forces that shape their distribution across the genome. SNPs have been shown to not be distributed evenly, with directly adjacent SNPs found unusually frequently. Why this is the case is unclear. We illustrate how neighbouring SNPs that can’t be explained by a single mutation event (that we term here sequential dinucleotide mutations, SDMs) are driven by distinct mutational processes and selective pressures to SNPs and multinucleotide polymorphisms (MNPs). By studying variation across multiple populations, including a novel cohort of 1,358 Scottish genomes, we show that, SDMs are over twice as common as MNPs and like SNPs, display distinct mutational spectra across populations. These biases are though not only different to those observed among SNPs and MNPs, but also more divergent between human population groups. We show that the changes that make up SDMs are not independent, and identify a distinct mutational profile, CA → CG → TG, that is observed an order of magnitude more often than other SDMs, including others that involve the gain and subsequent deamination of CpG sites. This suggests these specific changes are driven by a distinct process. In coding regions particular SDMs are favoured, and especially those that lead to the creation of single codon amino acids. Intriguingly selection has favoured particular pathways through the amino acid code, with epistatic selection appearing to have disfavoured sequential non-synonymous changes.
Bacteria associated with jellyfish during bloom and post-bloom periods
Authors: Kramar Maja Kos , Tinta Tinkara , Lučić Davor , Malej Alenka , Turk Valentina 
Published: May 2018

AbstractThis study is the first to investigate bacterial community associated with live medusaAurelia sp. in the Gulf of Trieste (northern Adriatic Sea) using both culture independent and culture-based methods. We have analysed bacterial community composition of different body parts of medusa: exumbrella surface, oral arms (‘outer’ body parts) and of gastric cavity (‘inner’ body part) and investigated possible differences in medusa associated bacterial community structure at the time of jellyfish population peak and during senescent phase at the end of bloom, when jellyfish start to decay. Based on 16S rRNA clone libraries and denaturing gradient gel electrophoresis (DGGE) analysis, we demonstrated significant difference between bacterial community associated withAureliaand the ambient seawater bacterial assemblage. Comparing bacterial community composition between differentAureliamedusa body parts, communities differed significantly, especially the one within the gastral cavity. The pronounced difference is dominance ofBetaproteobacteria(Burkholderia, CupriavidusandAchromobacter) in gastral cavity of medusa andAlpha- (Phaeobacter, Ruegeria) andGamma-proteobacteria(Stenotrophomonas, Alteromonas, PseudoalteromonasandVibrio) on ‘outer’ body parts. This suggests that body-part specific bacterial association might have an important functional roles for the host. The results of bacterial isolates showed the dominance ofGammaproeteobacteria, especiallyVibrioandPseudoalteromonasin all body parts. Finally, comparison of medusa associated bacterial community structure, at the time of jellyfish population peak and during senescent phase at the end of bloom showed increased abundance ofGammaproteobacteria, especiallyVibrio. Our results suggest members ofVibriogroup are possible commensal opportunistic visitors, later becoming consumer of moribund jellyfish biomass and that the structure of jellyfish bacterial community might be affected by anthropogenic pollution in the marine environment.
Synthesis, Biological Activity and Molecular Docking of New Tricyclic Series as α-glucosidase Inhibitors
Authors: Abuelizz Hatem A. , Iwana Nor Azman N. I , Ahmad Rohaya , El-Hassane Anouar , Marzouk Mohamed , Al-Salahi Rashad 
Published: May 2018

AbstractDiabetes is an emerging metabolic disorder. α-Glucosidase inhibitors, such as acarbose, delay the hydrolysis of carbohydrates by interfering with the digestive enzymes. This action decreases the glucose absorption and the postprandial glucose level. We have synthesized 25 tricyclic 2-phenoxypyrido[3,2-e][1,2,4]triazolo[1,5-a]pyrimidin-5(4H)-ones hybrids and evaluated their α-glucosidase inhibitory activity. Compounds 6h and 6d have shown stronger activity than that of acarbose. Compound 6h exhibited the highest inhibition with an IC50 of 104.07 mM. Molecular modelling studies revealed that compound 6h inhibits α-glucosidase due to the formation of a stable ligand–α-glucosidase complex and extra hydrogen bond interactions, and directed in the binding site by Trp329.
Influence of plant growth regulators and nitrogen sources on the production and development of Brachiaria decumbens cv. Basilisk
Authors: Rocha Leone Campos , Teixeira Fábio Andrade , dos Santos Pedreira Márcio , Fries Daniela Deitos , Costa Evely Giovanna Leite , Cláudia Maia Soares Ana , Dias Daniel Lucas Santos , José de Figueiredo Abdias , Seixas Angel Amaral , Pacheco Camile Carvalho 
Published: May 2018

ABSTRACTThe aim was to evaluate the effect of seed treatment with plant growth regulators and nitrogen fertilization methods in Brachiaria decumbens cv. Basilisk on the growth and development through germinative characteristics, dry matter yield and physiological composition. Plant growth regulators increased germination and mass yields of plant structures in coated seeds. From the regression estimates, higher germination percentages and root dry mass production were obtained with the use of Plant growth regulators for the initial growth (10.3; 12.8 mL.kg−1 seed, respectively). Leaf and pseudostem mass production had a significant interaction effect between seed type and the use of growth regulator. Coated seeds had greater performance with absence or at lower levels of growth regulators, and embryo quality contributed to the greater formation of plant tissues. More efficient levels (8.85 and 9.57 mL.kg−1 seed) were observed for the yields of plant structures (leaf and pseudostem). Soil N-fertilization resulted in higher dry mass productions of leaf, stem, shoot and root, as well as for root volume. Rates of photoassimilate were increased by soil fertilization and use of plant growth regulators. The use of exogenous hormonal compounds acts on the organogenesis of plant tissues and increases the development of Brachiaria decumbens cv. Basilisk. Soil N-fertilization increase mass yields as it maximizes photosynthetic processes and growth rates.
Visual trends in the annual report: the case of Ericsson 1947-2016
Authors: Havemo Emelie 
Published: May 2018

Purpose
Disclosure research has argued that visuals are increasingly used in annual reports as a way to increase readability of the annual report, but comparatively little is known about of diagrams compared to graphs and photographs. The purpose of this paper is to provide a historical account of visuals use in corporate disclosure, with an emphasis on diagrams, to show changes from the 1940s until present-day reporting.

Design/methodology/approach
Visual research methods were applied to analyze how diagrams, photographs and graphs were used in 69 annual reports of the Swedish telecom company Ericsson.

Findings
Photographs have been used with increasing frequency since the 1950s. Graph and diagram use has increased significantly since the 1990s while photograph use remained stable, suggesting that graphs and diagrams increasingly complement photographs for visually representing the organization in corporate disclosure. Factors explaining the case company’s development include both internal (performance, individual preferences, shifting from a manufacturing-based strategy to a service-based strategy) and external (legislation, transformation of the telecom industry).

Originality/value
Visual elements in annual reports are increasingly oriented toward immaterial representations of the organization’s standings and identity and diagrams are increasingly used and contribute to this. This finding motivates further research about diagram use in corporate communication, such as how different diagram types convey accounting messages, and whether diagrams serve as impression management devices. For regulators, it will be important to follow the emerging trend of diagram use, since it is becoming part of reporting practice.
The German medical cannabis law of 2017
Authors: Grotenhermen Franjo 
Published: May 2018

Purpose
The purpose of this paper is to give a review on the developments leading to the 2017 law on the medical use of cannabis and cannabinoids in Germany, and to present the major advances arising from this law for the supply of patients with cannabis-based drugs and its major limitations.

Design/methodology/approach
This paper used an Analysis of the major political statements and documents as well as court decisions of the past 20 years, which can be regarded as the major steps of this development.

Findings
Since 1998, when dronabinol/THC was made available in Germany on prescription there have been continuous improvements of the access to cannabis-based medicines. The law of 2017, which made cannabis flowers available to patients on a doctor’s prescription and forced health insurers to pay for a treatment under certain circumstances was a major step. However, many patients, who profit from a treatment with cannabis still do not get access.

Originality/value
The German law on the medical use of cannabis and cannabinoids of 2017 is unique in its kind in the world. Compared to the legal framework in other countries it has several disadvantages, for example with regard to the high prices of cannabis flowers (€20-€25 per gram), and several advantages, for example with regard to the role of health insurers.
The establishing of a European industrial relations system
Authors: Begega Sergio González , Aranea Mona 
Published: May 2018

Purpose
The purpose of this paper is to examine European Union (EU) industrial relations in their development over time. It describes and analyzes their main constituent parts, which are deployed along four interlinked institutional dimensions: tripartite concertation; cross-industry social dialogue; sectoral social dialogue; and employee representation and negotiation at the transnational company level. The focus lies strictly on the emerging EU layer of industrial relations, which is common to the different Member States and not on comparative European industrial relations.

Design/methodology/approach
The paper is conceptual in nature. It considers the differences and mutually interdependent legal and political processes, policies and institutions between EU industrial relations and national industrial relations.

Findings
The findings substantiate that EU industrial relations constitute an incomplete but perfectly traceable transnational reality distinct from industrial relations in the Member States. EU industrial relations are not to supersede but to supplement national industrial relations. Neither the EU institutional framework nor the European social partners have the mandate, legitimation or desire to perform a more ambitious role.

Research limitations/implications
More empirically oriented research would further support the findings in the paper.

Originality/value
The paper presents a conceptual review based on a comprehensive and critical reading of the literature on EU industrial relations. It also puts labor strategies at the forefront of the analysis in corporate relocation.
“Life-changing things happen”
Authors: Clancy Sharon Louise , Holford John 
Published: May 2018

PurposeThe purpose of this paper is to examine the implications for adults of learning in a residential context and whether the residential aspect intensifies the learning process, and can lead to enhanced personal transformation, moving beyond professional skills and training for employability.Design/methodology/approachThe paper reports on research, conducted in 2017, with 41 current and former staff and students (on both short courses and longer access courses) in four residential colleges for adults: Ruskin, Northern, Fircroft and Hillcroft Colleges.FindingsKey findings include the powerful role residential education plays in accelerating and deepening learning experiences, particularly for adults who have faced extraordinary personal and societal challenges and are second chance learners. The colleges, all in historic settings, confer feelings of worth, security and sanctuary and the staff support – pastoral and academic, bespoke facilities and private rooms are vital enabling mechanisms. Seminar-style learning creates opportunity for experiential group learning, helping to foster critical thinking and challenge to mainstream views.Social implicationsThe colleges’ ethos, curricula and traditions foster among students an “ethic of service” and a desire to offer “emotional labour” to their own communities, through working for instance in health and social care or the voluntary sector.Originality/valueLittle research has been undertaken in contemporary settings on the impact of learning in a residential environment, particularly for second chance learners and vulnerable adults. Still less research has examined the wider implications of learning in a historic building setting and of learning which extends into critical thinking, intellectual growth, transformation and change.
Inter-organizational fit and environmental innovation in supply chains
Authors: Shou Yongyi , Che Wen , Dai Jing , Jia Fu 
Published: May 2018

PurposeThrough examining the two constructs of inter-organizational complementarity and inter-organizational compatibility in supply chains, the purpose of this paper is to develop a taxonomy of focal firms’ inter-organizational fit (IOF) configurations with their suppliers and customers, and examine the relationship between these configurations and environmental innovation (EI) in order to answer the question of “with whom” to collaborate for EI development.Design/methodology/approachA survey instrument was elaborated and data from a sample of 171 US firms were collected. The authors adopted cluster analysis to identify the IOF taxonomy. Canonical discriminant analysis was employed to uncover underlying dimensions between clustering variables and cluster membership. Then, ANOVA tests were conducted to investigate relationships between IOF configurations in the context of EI in supply chains.FindingsThree configurations were identified based on the complementarity and compatibility between focal firms and their supply chain partners. It is observed that the overall IOF level is positively related to firms’ EI outcomes. Moreover, inter-organizational complementarity facilitates incremental EI while inter-organizational compatibility plays a more crucial role in radical EI. Both are required to achieve the best innovation outcome.Originality/valueThis research develops the first taxonomy for depicting IOF in a supply chain innovation context and also clarifies different rationale behind the development of incremental and radical EI through examining distinctive effects of the complementarity and compatibility with supply chain partners.
How public sport centers can improve the sport consumer experience
Authors: Cepeda-Carrión Ignacio , Cepeda-Carrion Gabriel 
Published: May 2018

PurposeThe sport consumer experience is becoming an important aspect to sport center’s management. From this point, the purpose of this paper is to explore and examine the relationship between sport centers’ absorptive capacity and sport consumer experience, proposing that internal knowledge management processes act as mediators in this relationship.Design/methodology/approachThe study offers empirical insights by applying the consistent PLS algorithm (PLSc-SEM) in an analysis of data from 156 sport centers in Andalusia (Spain) and a sample of 3,150 sport users from these sport centers.FindingsThe results demonstrate that a sport center’s absorptive capacity for external knowledge is crucial for enhancing the sport consumer experience and also that this effect requires additional knowledge management, such as the sport center’s knowledge storage and knowledge application.Practical implicationsThe practical implication for sport center managers is that knowledge management processes have a very strong influence on the sport consumer experience, when they are managed in a sequential way.Originality/valueThe main value of this paper is draw conclusions using a study of sport managers and sport consumers to increase value experience of those ones.
Roadmap to collaboration: journey from silos to enterprise
Authors: LugoSantiago José A. 
Published: May 2018

Purpose
Collaboration facilitates competitive advantages. That’s the reason why every leader should be concerned with whether his or her part of the organization embraces collaboration or not. Collaboration in itself is an instrumental value, and it should be pursued as part of an organization’s enterprise-wide strategy, especially in merged organizations. Unfortunately, the natural inclination in merged organizations is for the merged entities to continue the past practice of independent, autonomous operations. When merged, the separate entities of the new organization naturally resist integration. The leader must infuse collaboration to enable knowledge sharing and the integration and employment of the new organization’s capabilities. The following discussion presents a roadmap to collaboration focused on the leader’s employment of seven critical practices.

Design/methodology/approach
Concept Paper

Findings
Scholarly study points to collaboration as an instrumental value. If it must become a value in the organization, then leaders must use seven practices as part of an enterprise-wide strategy and carefully follow the implementation of the seven practices until collaboration becomes a value and the natural instinct of the organization.

Originality/value
Leaders struggle with how to bring collaboration into an environment where inertial forces impede it. The following discussion presents a roadmap to infuse collaboration and grow an appreciation for it because this process will facilitate the development and implementation of goals, objectives and action plans for the organization. Seven practices are discussed and integrated into an operational design-like method just like the one commanders use to achieve victories in military campaign planning and execution.
Staples: strategic evolution and decline in retailing
Authors: Strong John S. 
Published: May 2018

Purpose
This paper aims to analyze strategic decline in office supply retailing. The paper describes how inconsistent and biased internal decisions and perspectives can lead to decline, even for retailers, once dominant in their sector.

Design/methodology/approach
This paper is a case study of Staples and the US office supply industry over a 30-year period.

Findings
A series of inconsistent and contradictory strategic decisions led to the decline of Staples, the world’s largest office supply retailer. With a backdrop of increasing online competition, Staples failed to rethink the role of its store network, lost its value positioning and embarked on an inconsistent and flawed acquisition strategy.

Originality/value
This paper shows the need for retail companies to continue to develop strategies for traditional formats while moving into a multichannel competitive environment. The paper concludes with nine lessons for retailers, involving the need for distinct channel strategies, reinforcing of value positioning and the importance of an internal focus on strategic evolution.