bluuebunny/crossref_metadata_2025_split huggingface dataset:
Narrativas da Fronteira: paisagens discursivas da imigração venezuelana no Brasil
Authors: Biar Liana de Andrade , Silva Maressa Fernanda Almeida da 
Published: November 2024

Neste artigo atendemos ao chamado interdisciplinar para mapear práticas migrantes, lançando mão da noção de paisagens discursivas. Observamos os discursos da/sobre a circulação e presença de solicitantes de refúgio de origem venezuelana nas cidades de Boa Vista e Pacaraima, estado de Roraima. Os dados advêm de trabalho de campo e entrevistas qualitativas gravadas na região nos anos de 2018 e 2019. Especificamente, focalizamos narrativas orais produzidas pelos próprios atores sociais implicados no fenômeno – solicitantes de refúgio, habitantes de Roraima, gestores governamentais e não-governamentais. As análises, de base qualitativa e interpretativa, de orientação discursiva, iluminam o modo como os sujeitos narrativamente constroem o espaço da fronteira, organizando o mundo social que os cerca e os colocando em relação com a experiência migratória e com os discursos circulantes.
Divertículo de Meckel de presentación en edad atípica
Authors: González Haden , Notejane Martín , Vomero Alejandra , Fein Lucía , Pereira Diego , García Loreley 
Published: November 2024

Introducción: el divertículo de Meckel (DM) es la malformación congénita gastrointestinal más frecuente, resultado de la falla de la obliteración del conducto onfalomesentérico. Se presenta habitualmente en menores de 2 años. La mayoría permanecen asintomáticos. El tratamiento dependerá de si la presentación clínica fue sintomática o un hallazgo imagenológico o laparoscópico.
Caso clínico: adolescente de 11 años, sexo femenino. Siete días previos a la consulta, comienza con enterorragia, cuatro a cinco episodios por día. En la evolución, presenta melenas, no dolor abdominal, ni fiebre. El día del ingreso instala cefalea, mareos, palpitaciones y fatiga. Examen físico: Glasgow 15, FC 110 lpm, FR 20 rpm, presión arterial 100/60 mmHg. Palidez cutáneo-mucosa intensa. Abdomen: blando, depresible, dolor a la palpación profunda de epigastrio. Se colocó sonda nasogástrica, aspirando líquido gástrico claro. Estudios: hemograma: Hb 6,3 g/dl, HTO 16,8%, plaquetas 343.000/mm³, glóbulos blancos 19.400/mm³. Crasis sanguínea normal. Se realizó transfusión de glóbulos rojos. Ecografía abdominal normal. Fibrogastroscopía sin alteraciones. Centellograma evidenció DM. Se realizó resección de segmento intestinal que incluye el DM y anastomosis íleo-ileal término-terminal por vía laparoscópica. Buena evolución, sin complicaciones.
Conclusiones: si bien el DM suele presentarse en niños pequeños, el pediatra debe mantener un alto índice de sospecha en escolares y adolescentes con clínica sugestiva. La enterorragia, acompañada de melenas sin dolor abdominal espontáneo, suele orientar el diagnóstico. Es fundamental realizar un diagnóstico precoz y un tratamiento oportuno.
TRANSFORMATION OF ISLAMIC PHILANTHROPY BY THE IDRISIYYAH TARIQA IN THE DIGITAL ERA
Authors: Munandar Siswoyo Aris , Fahrurrozi Fahrurrozi 
Published: November 2024

<p align="center"><strong>Abstract</strong></p><p><strong> </strong></p><p><em>This article explores the transformational role of the Tarekat Idrisiyyah in the practice of Islamic philanthropy in the digital era through the Agen Care initiative. By utilizing information and communication technology, Agen Care has succeeded in increasing the efficiency of donation management, expanding the reach of social programs to remote areas, and increasing public awareness of the importance of social piety. Programs such as waqf, direct cash assistance, house renovation, education and health implemented by Care Agents have had a significant positive impact on the community. However, several technical and sustainability challenges are still faced. Implementation of these new strategies opens up opportunities to strengthen the role of the Idrisiyyah Tarekat as a relevant and effective agent of social change in the digital era. This article highlights how technology can strengthen and expand charitable activities, fulfill religious obligations, and contribute to creating a more prosperous and socially just society.</em></p><p> </p><p> </p>
Evaluation of gestational weight gain in women with twin pregnancies and its relationship to neonatal birth weight. A pilot study
Authors: Wierzejska Regina 
Published: November 2024

BackgroundTo date, there have been no studies in Poland on weight gain in women with twin pregnancies in relation to recommendations.ObjectiveThe aim of this study was to analyze the gestational weight gain of women with twin pregnancies depending on their body weight before pregnancy, and to assess the relationship between the observed weight gain and the neonatal birth weight.Material and MethodsThe study was conducted among 50 women in twin pregnancies and their 100 newborns delivered
after 36 weeks of gestation. Gestational weight gain was assessed based on the American Institute of Medicine guidelines for women in twin pregnancies. Data on the pre-pregnancy body weight and gestational weight gain were collected by interviewing the patients. Neonatal data were obtained from the hospital medical records.ResultsNormal gestational weight gain was observed only in 38% of the women. In women with monochorionic pregnancy, too low body weight gain occurred almost 3 times more often than in women with dichorionic pregnancy (74% vs. 26%), (p<0.001). Women with monochorionic pregnancies also gave birth to statistically significantly more newborns with low birth weight (<2500 g), compared to women with dichorionic pregnancies (62.5% vs. 37.5%) (p=0.007). The mean birth weight of newborns born to mothers with excessive weight gain was 151 g higher than children born to mothers with normal weight gain (2727 g vs. 2576 g) (p=0.035).ConclusionsIn the majority of studied women in twin pregnancies, gestational weight gain was not compliant with the current recommendations. The risk of insufficient weight gain is higher in women with monochorionic pregnancies compared to women with dichorionic pregnancies.
Immunomodulatory activity of kersen leaf extract (Muntingia calabura) on diabetic rats: analysis of immune response
Authors: Hasan Fonnie Esther , Yunus Reni , Magdalena Magdalena 
Published: November 2024

The immune response to high blood glucose levels leads to an inflammatory response and also produces inflammation mediators. Immunomodulatory functions of Kersen (Muntingia calabura) need further enhancement to ensure that its benefits are more widely recognized by the public. This study aims to determine the immunomodulatory activity of Kersen leaf in inducing and modulating the immune response in diabetic rats. This study was an experimental laboratory with a pre-and post-test with a control group design. The subjects were 30 white rats (Rattus Novergicus Wistar Strain), were treated with extract M. calabura dose 1 (100 mg/kg bw/day), dose 2 (200 mg/kg bw/day), dose 3 (300 mg/kg bw/day). For clinical evaluation, three control groups were formed, including a Normal Control Group, a Diabetes Mellitus (DM) Positive Group, and a DM Positive Group treated with Anti-Diabetic Drugs. The highest amount of IFN-γ concentrations were found in the DM positive control group + antidiabetic drugs (710.3 ± 27.2 ng/mL). The highest number of Nitrit Oxide (NO) concentration was found in the DM positive control group (103.7 ± 10.2 µmol/L). The highest average amount of pancreatic β cell regeneration was found in the normal control group. The DM positive control group and the treatment group had a significant difference (p < 0.05) It means that there is a significant difference in the data of all treatment groups, or these three groups have anti-diabetic activity by repairing or preventing damage to the pancreas organ in DM rats. This study revealed that M. calabura possesses immunomodulatory activity, capable of inducing and modulating immune responses in diabetic rats.
Emotions and self-efficacy toward simple machines learning through a STEM practice
Authors: Muñoz-Losa Aurora , Marcos-Merino José María 
Published: November 2024

IntroductionThis study explores the impact of an interactive physics class on the emotions and self-efficacy of elementary education students, specifically in their future roles as educators using STEM-based pedagogical methods. The research aims to understand how such an approach affects students’ emotional responses and confidence in teaching STEM topics.MethodsThe sample included 97 fourth-year prospective elementary teachers. Participants completed pretests and posttests measuring emotions and self-efficacy related to both course content and the pedagogical approach.ResultsFindings indicated a significant increase in both positive emotions and self-efficacy following the interactive class. Male students reported higher levels of positive emotions and self-efficacy than their female peers. Furthermore, students with backgrounds in sciences and technology showed greater improvement compared to those from social science backgrounds. A positive correlation between emotions and self-efficacy was observed.DiscussionThe manipulative, collaborative, and interdisciplinary nature of the physics class likely contributed to the observed positive changes in emotions and self-efficacy. Network analysis suggested that reducing boredom could enhance emotional responses, given its role in affecting both positive and negative emotions. On the other hand, it has been observed that uncertainty could be beneficial in STEM activities due to their relationship with self-efficacy.
Research on the efficiency and spatiotemporal evolution characteristics of agricultural green development in central cities of the Yangtze River Delta
Authors: Han Guanghui , Yang Haichao , Xie Hui 
Published: November 2024

IntroductionAgricultural green development (AGD) prioritizes sustainable growth by integrating economic, ecological, and social dimensions, aiming to harmonize agricultural economic development with environmental protection and social progress.MethodsThis study integrates the three-stage super-efficiency DEA-SBM model with the BP algorithm, creating an advanced DEA-SBM-BP model to overcome the shortcomings of traditional DEA in evaluation and management processes. The study further applies the Dagum Gini coefficient, kernel density estimation (KDE), and Moran’s index to assess and forecast the efficiency and spatiotemporal evolution patterns of green agricultural development in key cities within the Yangtze River Delta.ResultsThe analysis shows that AGD in the central city of the Yangtze River Delta is overall balanced; however, substantial variations exist among cities within individual provinces. Factors like macroeconomic conditions, workforce quality, and policy support play a crucial role in promoting the efficiency of AGD. Among these, macroeconomic development level has a negative impact, while labor quality and policy support exhibit bidirectional effects. Infrastructure construction, digitalization of agricultural economy, and rural security have become key factors in the green development of modern agriculture. The green advancement of agriculture in the central Yangtze River Delta region typically exhibits a marked clustering effect; however, the local clustering reveals a trend toward dispersed development.DiscussionDespite the emergence of new characteristics in agricultural production in China within the context of high-quality development, differences in resource endowments and economic structures among cities continue to be significant factors contributing to regional imbalances and changes in the agglomeration patterns of agricultural development.
Assessing the impact of contraceptive use on reproductive cancer risk among women of reproductive age—a systematic review
Authors: Jahanfar Shayesteh , Mortazavi Julie , Lapidow Amy , Cu Cassandra , Al Abosy Jude , Morris Kathyrn , Becerra-Mateus Juan Camilo , Steinfeldt Meredith , Maurer Olivia , Bohang Jiang , Andrenacci Paola , Badawy Marwa , Ali Moazzam 
Published: November 2024

BackgroundContraceptives play a crucial role in women's reproductive health, their hormonal components may be linked to cancer risks, specifically breast, and gynecological cancers. Given the high usage rates of hormonal contraceptives, it is vital to systematically evaluate their potential impact on cancer outcomes, especially among women with a family history of gynecological cancers.ObjectivesThis study aims to evaluate the evidence on the association between modern contraceptive use and the risk of breast and reproductive cancers (ovarian, endometrial, and cervical cancer) among women of reproductive age, to inform healthcare providers, women, and program managers about cancer outcomes related to contraceptive use.MethodsA systematic review was conducted according to PRISMA guidelines. Searches were performed in databases such as CINAHL, OVID Medline, EMBASE, and more from inception to February 2022. Eligible studies included randomized controlled trials, cohort studies, and case-control studies that compared cancer outcomes between contraceptive users and non-users. Data extraction, quality assessment, and meta-analyses were conducted following predefined protocols. Subgroup and sensitivity analyses examined variations in contraceptive methods, doses, and duration.ResultsA total of 51 studies were included, comprising 2 RCTs and 49 observational studies. The review identified a significant reduction in ovarian and endometrial cancer incidence among contraceptive users. Hormonal contraceptive users had a 36% lower risk of ovarian cancer (RR 0.64, 95% CI 0.60–0.68), with specific reductions seen in combined oral contraceptive users (RR 0.62, 95% CI 0.57–0.68) and hormonal IUD users (RR 0.68, 95% CI 0.48–0.96). The rate ratio of cervical cancer was higher among non- users compared to hormonal contraceptive users when we pooled the results (1.28, 95% CI 1.21, 1.35). No significant association was found between contraceptive use and breast cancer risk among healthy women (RR 1.00, 95% CI 0.94–1.06). However, BRCA1/2 mutation carriers using oral contraceptives showed a heightened risk of breast cancer (HR 1.39, 95% CI 1.15–1.67).ConclusionThis systematic review highlights the protective effects of modern contraceptives against ovarian and endometrial cancers while identifying an increased risk of cervical. No significant breast cancer risk was found for healthy women, but BRCA1/2 mutation carriers faced increased risks. These findings underscore the need for personalized contraceptive counselling that considers cancer risk factors. Further research is needed to explore contraceptive impacts across different genetic profiles and dosing regimens.Systematic Review Registrationhttps://www.crd.york.ac.uk/prospero/, Prospero (CRD42022332647).
Africanized honeybee venom (Apis mellifera) promotes human complement activation split products storm
Authors: Silva de França Felipe , de Oliveira Orsi Ricardo , Fernandes Dayanne Carla , Leonel Thyago Bispo , Tambourgi Denise V. 
Published: November 2024

IntroductionComplement activation split products are signatures of many immunopathological disorders. Among the laboratory findings observed in these diseases, a reduction in the level of circulating intact complement components can be mentioned, and this change has also been detected in envenomation by multiple Africanized honeybee (Apis mellifera) stings. Although envenomation by these animals elicits diverse life-threatening reactions, the capacity of bee venom (AmV) to activate the human complement system remains elusive.Methods and findingsBy coupling immunochemical and functional approaches, it was observed that AmV strongly consumes components of the alternative pathway (AP) of the complement system in normal human serum (NHS). Additionally, AmV interfered with classical (CP) and lectin pathways (LP) activities. In parallel, a high increase in Ba fragment levels was detected, suggesting that the changes in AP activity were due to its activation. Furthermore, an increase in the level of the C1s-C1INH complex and a decrease in the physiological level of MASP1-C1INH suggested that CP and LP were also activated in the presence of AmV. Strikingly, NHS exposed to increasing AmV concentrations varying from 5 to 1000 µg/mL presented a high generation of C3a, C4a and C5a anaphylatoxins, and sC5b-9 complexes assembly, thus reinforcing that AmV triggers complement activation.ConclusionThese results show that AmV is a strong complement activator. This activation presents a mixed profile, with a predominance of AP activation. This suggests that complement split products can play important roles in the envenomation by Africanized honeybee, as they could induce diverse immunopathological events observed in patients and may also dictate patient clinical prognosis.
Impact of induction agents and maintenance immunosuppression on torque teno virus loads and year-one complications after kidney transplantation
Authors: Reineke Marvin , Speer Claudius , Bundschuh Christian , Klein Julian A. F. , Loi Lisa , Sommerer Claudia , Zeier Martin , Schnitzler Paul , Morath Christian , Benning Louise 
Published: November 2024

BackgroundTorque teno virus load (TTVL) is gaining importance as a surrogate parameter to assess immunocompetence in kidney transplant recipients. Although the dynamics of TTVL have been investigated before, the impact of different induction agents and variations in immunosuppressive maintenance therapies on TTVL remain unknown.MethodsIn this retrospective study, TTVL was quantified in 537 plasma or serum samples from 134 patients transplanted between 2018 and 2021. TTVL was examined pre-transplantation and 30-, 90-, 180-, and 360-days post-transplant. To assess the influence of induction therapy on TTVL, 67 patients receiving anti-thymocyte globulin (ATG) induction were matched with 67 patients receiving an interleukin-2 receptor antagonist (IL2-RA) induction in terms of age, sex, and donor modality.ResultsFollowing transplantation, there was a steep increase in TTVL post-transplant for all patients with peak viral loads at 90 days post-transplant (median TTVL [IQR] 7.97×106, [4.50×105–1.12×108]) followed by subsequently declining viral loads. Compared to patients receiving IL2-RA as induction therapy, patients receiving ATG had significantly higher peak viral loads 3 months post-transplant (median TTVL [IQR] 2.82×107 [3.93×106–1.30×108] vs. median TTVL [IQR] 2.40×106 [5.73×104–2.60×107]; P&lt;0.001). Throughout all post-transplant time points, patients receiving additional rituximab for induction along with higher tacrolimus target levels exhibited the highest TTVL.Patients whose TTVL 3-months post-transplant exceeded the currently proposed cutoff to predict infections within the first year post-transplant [6.2 log10] showed a trend towards a higher risk of being hospitalized with an infection in the following 9 months, albeit without being statistically significant (HR=1.642, P=0.07).ConclusionsHigher TTVL reflects the greater immunosuppressive burden in immunological high-risk patients receiving intensive immunosuppression. The choice of induction agent and intensified immunosuppressive maintenance therapy notably affects TTVL at 3 months post-transplant and beyond, necessitating careful consideration when interpreting and applying TTVL cutoffs to monitor immunocompetence post-transplant.
Contrastive learning for neural fingerprinting from limited neuroimaging data
Authors: Kampel Nikolas , Abdellatif Farah , Shah N. Jon , Neuner Irene , Dammers Jürgen 
Published: November 2024

IntroductionNeural fingerprinting is a technique used to identify individuals based on their unique brain activity patterns. While deep learning techniques have been demonstrated to outperform traditional correlation-based methods, they often require retraining to accommodate new subjects. Furthermore, the limited availability of samples in neuroscience research can impede the quick adoption of deep learning methods, presenting a challenge for their broader application in neural fingerprinting.MethodsThis study addresses these challenges by using contrastive learning to eliminate the need for retraining with new subjects and developing a data augmentation methodology to enhance model robustness in limited sample size conditions. We utilized the LEMON dataset, comprising 3 Tesla MRI and resting-state fMRI scans from 138 subjects, to compute functional connectivity as a baseline for fingerprinting performance based on correlation metrics. We adapted a recent deep learning model by incorporating data augmentation with short random temporal segments for training and reformulated the fingerprinting task as a contrastive problem, comparing the efficacy of contrastive triplet loss against conventional cross-entropy loss.ResultsThe results of this study confirm that deep learning methods can significantly improve fingerprinting performance over correlation-based methods, achieving an accuracy of about 98% in identifying a single subject out of 138 subjects utilizing 39 different functional connectivity profiles.DiscussionThe contrastive method showed added value in the “leave subject out” scenario, demonstrating flexibility comparable to correlation-based methods and robustness across different data sizes. These findings suggest that contrastive learning and data augmentation offer a scalable solution for neural fingerprinting, even with limited sample sizes.
Impact of serum carotenoids on cardiovascular mortality risk in middle-aged and elderly adults with metabolic syndrome
Authors: Han Jing , Wang Ruiyun , Bai Lijuan , Liu Yun , Liao Man , Zhang Liting , Liu Lihua , Qi Benling 
Published: November 2024

BackgroundMetabolic syndrome (MetS), characterized by abdominal adiposity, hypertension, hyperglycemia, and dyslipidemia, is associated with dysregulated immune function, elevated oxidative stress, and chronic low-grade inflammation. Aging exacerbates insulin resistance and the prevalence of MetS. Dietary antioxidants, such as carotenoids, may play a role in preventing cardiovascular disease (CVD) mortality, but evidence remains mixed, particularly among middle-aged and elderly individuals with MetS.MethodsWe analyzed data from 6,601 participants aged 40 years and above with MetS from the National Health and Nutrition Examination Survey (NHANES) III (1988–1994) and NHANES 2001–2006 cycles. Serum concentrations of α-carotene, β-carotene, lycopene, β-cryptoxanthin, and combined lutein/zeaxanthin were quantified. Participants were followed for a median of 16.8 years. Cox proportional-hazards models were used to assess the association between serum carotenoid concentrations and CVD mortality risk, with adjustment for potential confounders.ResultsDuring the follow-up period, 1,237 CVD deaths were identified. Analysis revealed an inverse dose–response relationship between serum lycopene levels and cardiovascular mortality risk. Compared to the lowest quartile, the multivariable-adjusted hazard ratios (95% confidence intervals) for ascending quartiles of serum lycopene were 0.84 (0.71, 1.00), 0.87 (0.74, 1.03), and 0.77 (0.61, 0.97), with a significant trend (p = 0.039). No significant associations were observed for other carotenoids.ConclusionIn this prospective cohort study of 40-year-old and older individuals with MetS, we observed an inverse association between serum lycopene levels and CVD mortality risk.