bluuebunny/crossref_metadata_2025_split huggingface dataset:
Photopolymerizable biogel scaffold seeded with mesenchymal stem cells: safety and efficacy evaluation of novel treatment for intervertebral disc degeneration
Authors: Vaudreuil Nicholas , Henrikson Karl , Pohl Pedro , Lee Andrew , Lin Hang , Olsen Adam , Dong Qing , Dombrowski Malcolm , Kang James , Vo Nam , Lee Joon , Sowa Gwen 
Published: December 2018

ABSTRACTTissue engineering approaches to treatment of intervertebral disc degeneration (IDD) represent a novel avenue of addressing the biologic basis of this disease. However, such approaches remain limited by their invasive nature and disruption to the annular fibrosis (AF). This study sought to explore a new minimally‐invasive tissue‐engineering approach utilizing an injection of a photopolymerizable biogel scaffold seeded with mesenchymal stem cells (MSCs) directly into the nucleus pulposus (NP). This study was performed using rabbit specimens for both in vivo and in vitro outcome measures. The treatment in this study was performed by injecting 25 μl of 10% (w/v) methacrylated gelatin biogel with 0.15% (w/v) lithium phenyl 2,4,6‐trimethylbenzoylphosphinate (LAP) and rabbit MSCs (1 × 106) cells/ml into the NP. Samples were then photopolymerized in situ using non‐ultraviolet light irradiation via a fiberoptic wire. For the in vitro arm of this study, gene expression analysis demonstrated increased anabolic activity in irradiated MSCs with and without biogel scaffolds. For the in vivo arm of this study, while GAG analysis did not demonstrate significant differences between groups, MRI analysis exhibited a trend toward improved NP matrix. Histological analysis was consistent with increased cellularity and less severe disc degeneration in the MSC + Gel group. However, osteophyte formation was noted in both Stab and MSC + Gel groups after the study period. Increased matrix gene expression of irradiated groups within in vitro studies indicates a photobiologic effect of 405 nm light. Despite promising anabolic actions, osteophyte formation and AF defects could not be avoided with implementation of this minimally‐invasive tissue‐engineering approach. © 2018 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 37:1451–1459, 2019.
Factors Associated With Use of Nonoral Nutrition and Hydration Support in Adult Patients With Postural Tachycardia Syndrome
Authors: Tseng Andrew S. , Traub Nicole A. , Harris Lucinda A. , Crowell Michael D. , Hoffman‐Snyder Charlene R. , Goodman Brent P. , DiBaise John K. 
Published: December 2018

AbstractBackgroundPatients with postural tachycardia syndrome (POTS) often have gastrointestinal (GI) symptoms. Occasionally, these symptoms can be so severe that nonoral nutrition/hydration support (NONHS), including intravenous fluids (IVFs), enteral nutrition (EN), and parenteral nutrition (PN), becomes necessary.MethodsThis is a retrospective cohort study of adult patients diagnosed with POTS at the Mayo Clinic Arizona from January 2010 to January 2017 with a minimum of 6 months of follow up. Demographic information, symptomatology, medications, GI testing, autonomic and autoantibody testing, and healthcare utilization data were abstracted from the electronic medical record.ResultsThree‐hundred thirty‐two patients with POTS were included, of which 32 required NONHS. Patients receiving NONHS were more likely to be female; have lower body mass index; have GI symptoms including nausea, vomiting, diarrhea, and constipation; have abdominal pain; use opiates; have delayed gastric emptying; see more specialists; and be seen in an emergency room or be hospitalized for symptoms. Of these patients, 21 (66%) required IVF, 19 (59%) required EN, and 9 (28%) required PN. Six (19%) patients required all 3 NONHS modalities at some point during their follow‐up period.ConclusionsNONHS may be required in a subset of patients with POTS. Those receiving NONHS have more severe symptoms and abnormal GI motility and autonomic testing and exhibit greater healthcare utilization. Management of these patients is complex and challenging and requires a multidisciplinary approach. Further prospective studies are needed to identify optimal management strategies.
A cost‐effectiveness analysis of DIEP vs free MS‐TRAM flap for microsurgical breast reconstruction
Authors: Tan Marcus G. , Isaranuwatchai Wanrudee , DeLyzer Tanya , Butler Kate , Hofer Stefan O. P. , O'Neill Anne C. , Zhong Toni 
Published: December 2018

Background and ObjectivesThe deep inferior epigastric perforator (DIEP) flap may be associated with less long‐term donor‐site morbidity compared with free muscle‐sparing transverse rectus abdominis myocutaneous flap (MS‐TRAM) flap. However, DIEP flaps may have longer operative time and higher rates of acute postoperative complications. We performed a cost‐effectiveness analysis (CEA) that compared the long‐term costs and patient‐reported outcomes between the two flaps.MethodsA retrospective cohort of women who received free MS‐TRAM or DIEP flap reconstruction between January 2008 and December 2012, with a minimum of 2‐year follow‐up, were recruited. Cost data of the primary reconstruction and any subsequent hospitalization due to complications from the reconstruction within 2 years were obtained. Each patient received a BREAST‐Q questionnaire at 2 years post‐reconstruction.ResultsIn total, 227 patients (180 DIEP, 47 free MS‐TRAM) were included. DIEP patients had significantly fewer abdominal hernia (P = 0.04). The adjusted‐incremental cost‐effectiveness ratios found that DIEP flap was more cost‐effective to free MS‐TRAM flap in the domains of “Physical Well‐Being of the Abdomen” and “Satisfaction with Outcome.”ConclusionsDIEP flap is the more cost‐effective method of autologous breast reconstruction in the long‐term compared with free MS‐TRAM flap with respect to patient‐reported abdominal well‐being and overall satisfaction with the outcome.
Gobbling chronology of eastern wild turkeys in South Carolina
Authors: Wightman Patrick H. , Kilgo John C. , Vukovich Mark , Cantrell Jay R. , Ruth Charles R. , Cohen Bradley S. , Chamberlain Michael J. , Collier Bret A. 
Published: December 2018

ABSTRACTEastern wild turkeys (Meleagris gallopavo silvestris) use a polygynous‐promiscuous mating system, wherein males compete for mating opportunities and communicate with females via courtship behaviors. One courtship behavior is vocalization (gobbling), which attracts females and signals dominance to other males. However, temporal variation in gobbling activity may be influenced by external stimuli, environmental variation, and hunter activity. Gobbling activity is a key determinant of hunter satisfaction, and gobbling chronology is often used by state agencies to inform regulatory processes. To identify factors influencing gobbling activity, we evaluated daily gobbling chronology on 3 sites in South Carolina, USA (Webb Wildlife Management Area [WMA] Complex, Savannah River Site, Crackerneck WMA) with different levels of hunter activity. We used autonomous recording units (ARUs; n = 45) across 8,280 days to collect 53,937 hours of ambient sound recordings and identified 68,426 gobbles. Gobbling activity varied daily and site interacting with minutes since sunrise best predicted daily gobbling activity. We noted distinct differences in predicted numbers of gobbles between hunted sites and an unhunted site, suggesting that hunting may be an important determinant of gobbling activity. Across our study sites, we observed that ≥72% of gobbling activity occurred between 30 minutes before and 60 minutes after sunrise. We found no clear evidence of well‐defined unimodal or bimodal peaks in daily or weekly gobbling activity. Across sites, <44% of gobbling activity occurred during legal hunting seasons in South Carolina, with between 30% and 48% of gobbling activity occurring after legal hunting seasons. Because hunter satisfaction is primarily influenced by gobbling activity, wildlife managers in South Carolina may consider adjusting dates of turkey hunting seasons to correspond hunting with periods when most gobbling occurs. © 2018 The Wildlife Society.
Prognostic impact of initial treatment in surgically salvaged recurrences of early glottic cancer
Authors: Locatello Luca Giovanni , Cannavicci Angelo , Gallo Oreste 
Published: December 2018

ObjectiveThe purpose of this study was to analyze the outcomes of surgically salvaged early glottic cancer (EGC) recurrences after initial radiotherapy (RT) or transoral laser microsurgery (TLM).MethodsA matched pair analysis by recurrent tumor‐node‐metastasis stage (rTNM) considering 27 patients who had TLM as initial treatment and 54 patients who failed after primary RT was performed. Post‐recurrence overall and disease‐specific survival (DSS) were evaluated.ResultsThe RT‐failed group showed worse post‐recurrence overall survival (P < .001) and DSS (P = .005) compared to TLM‐first group despite the same rTNM stage. The RT failed patients also showed more postoperative complications (longer mean decannulation time, P = .005; nasogastric feeding tube dependence, P = .012) and a higher rate of second locoregional recurrences (P = .004).ConclusionThe RT‐failed EGC showed worse outcomes in terms of survival, complications, and locoregional recurrences compared to same recurrent TNM stage TLM‐failed cases.Level of Evidence3Laryngoscope, 129:2328–2333, 2019
Use of Suspended Plastic Conduit Arrays during Brown Trout and Rainbow Trout Rearing in Circular Tanks
Authors: White Sarah C , Krebs Eric , Huysman Nathan , Voorhees Jill M , Barnes Michael E 
Published: December 2018

Abstract
Environmental enrichment is the modification of otherwise sterile hatchery rearing units to provide structural complexity. We investigated the use of an array of suspended plastic conduit sections as enrichment in large circular tanks during two experiments. Brown Trout Salmo trutta and Rainbow Trout Oncorhynchus mykiss were reared for 126 and 61 d, respectively, in covered, 3.63-m-diameter circular tanks that were either void of any structure or enriched with a suspended array of twenty 0.94-m-long sections of plastic conduit. Total tank weight gain and feed conversion ratio were significantly improved for both Brown Trout and Rainbow Trout reared with suspended conduit as enrichment compared to unenriched tanks. Enrichment did not significantly affect individual fish length, weight, or condition factor in either experiment, likely because of small sample sizes. The suspended array did not interfere with tank hydraulic self-cleaning. Based on the results of this study, the use of vertically suspended enrichment structures in circular tanks is recommended to improve trout rearing efficiencies.
Entrainment memories: What does stable mean?
Authors: Gödel Manfred 
Published: December 2018

AbstractDiurnal environmental factors (zeitgebers) set the circadian clock in an antagonistic way: The body clock is tuned forward in the morning, while the same factor late in the day puts the body clock back to a later time‐point: Morning light, for example, reduces the clock‐effective light‐reception (zeitnehmer2) by shifting the expression of the circadian, light‐processing, molecular machinery more into the late, light‐less night. Evening light does the same by a backward‐shift, respectively. The balance between these daily back and forth adaptations results in a synchronization of the organismic timing with its environment. Those traditional models are challenged in this study. Using Neurospora as a model, I will explore how the entrainment process follows diverging trajectories depending on zeitgeber structure and strength, and the kind of transition between different entraining situations. The diverging routes of entrainment, systematically becoming earlier and earlier or later and later until eventually settling in distinct entrained phases, point out the existence of a long‐range “memory” component. The view of entrainment as a non‐acute reaction is very well confirmed in feedback loops, limit cycles, phase‐response curves, and so forth. However, the presented findings enhance an extension of those concepts: The processing of zeitgebers by oscillating zeitnehmer modules resulting in a certain temporal inner structuring is not fully established within one repetition along a unique reaction norm. I hypothesize that the long‐range, multi‐cycle component in entraining requires a third parameter of description additional to current internal phase and zeitgeber condition, which originates from the differential of the two or more consecutive periodic situations. I hypothesize that this differential is represented by a gradient of Gibbs free energy of the entrainment pathways. Low points of free energy identify stable phases of entrainment. The fundamentality of Gibbs energy puts entrainment up for discussion not only as a timer but as an important kind of homeostasis.
The effect of phosphate ion on the ssDNA binding mode of MoSub1, a Sub1/PC4 homolog from rice blast fungus
Authors: Zhao Yanxiang , Zhang Yikan , Huang Jinguang , Wang Shanshan , Yi Long , Zhang Xin , Xu Min , Fang Xianyang , Liu Junfeng 
Published: December 2018

AbstractMoSub1 is an ortholog of yeast single stranded DNA binding protein Sub1 or human PC4 from rice blast fungus. All of them share a similar DNA binding region and may have similar biological roles. The well‐studied Sub1/PC4 has been reported to play multiple roles in DNA metabolic processes, such as transcription and DNA repair and their DNA binding capacity is significantly affected by phosphorylation. Here, we determined the crystal structure of MoSub1 complexed with ssDNA in a phosphate solution. The crystal structure of the MoSub1–ssDNA complex was solved to a resolution of 2.04 Å. A phosphate ion at the interface of the protein–DNA interaction of the complex bridged the lys84 of the protein and two nucleotides. The DNA was bound in novel mode (L mode) in the MoSub1 complex in the presence of phosphate ions, while DNA bound in the straight mode in the absence of the phosphate ion and in U mode in the same binding motif of the PC4–ssDNA complex. The crystal structure of the complex and a small‐angle X‐ray scattering analysis revealed that the phosphate ion at the protein–DNA interface affected the DNA binding mode of MoSub1 to oligo‐DNA and provided a new structural clue for studying its functions.
One‐Pot Multicomponent Synthesis of Pyrrolo[1,2‐a]pyrazines in Water Catalyzed by Fe3O4@SiO2‐OSO3H
Authors: Rostami Hedieh , Shiri Lotfi 
Published: December 2018

AbstractAn effective and green one‐pot multicomponent reaction for the synthesis of pyrrolo[1,2‐a]pyrazine derivatives by Fe3O4@SiO2‐OSO3H as a reusable magnetic nanocatalyst has been reported. Pyrrolo[1,2‐a]pyrazine derivatives are achieved reaction among ethylenediamine, dialkylacetylenedicarboxylates and β‐nitrostyrene derivatives in water as a green solvent with high to excellent yields. This catalyst was characterized by FT‐IR, SEM (scanning electron microscopy), EDX (energy dispersive X‐ray spectroscopy), VSM (vibrating sample magnetometry) and XRD (X‐ray diffraction) techniques.
Cobalt‐Zinc‐Diimine Multicatalysis: Enhanced syn Diastereoselectivity in the Reductive Multicomponent Coupling of Aryl Bromides, Acrylates and Aldehydes
Authors: Paul Jérôme , Xavier Tania , Presset Marc , Le Gall Erwan , Léonel Eric , Pichon Christophe , Condon Sylvie 
Published: December 2018

AbstractA cobalt‐zinc‐diimine multicatalytic system for the syn‐diastereoselective multicomponent assembly of aromatic bromides, acrylates and aromatic aldehydes under reductive conditions is described. In the presence of catalytic CoBr2phen and the ZnBr2N,N′‐diphenyl cyclohexyldiimine complex, β‐hydroxyesters are obtained with a significant up to 8:1 syn diastereoselectivity whereas reactions conducted without L2‐1 show negligible stereoselectivity. This preliminary study should open the way to further improvements including enantioselective catalysis of the reaction.
The parallel agile process: Applying parallel processing techniques to software engineering
Authors: Rosenberg Doug , Boehm Barry W. , Wang Bo , Qi Kan 
Published: December 2018

AbstractFor the last 4 years, we have been experimenting with the parallel agile (PA) approach. PA achieves significant schedule compression by leveraging parallelism; large teams of developers can independently and concurrently develop scenarios from initial concept through code.This paper summarizes our experience in defining and evolving PA by applying it to four representative emergent‐technology applications: location‐based advertising, picture sharing, bad driver reporting, and a VR/AR game project. In comparison with the mainstream architected agile process that we had been using on similar systems, the PA process has consistently achieved significant speedups in system development while simultaneously reducing defects.PA uses storyboards and prototypes to define both sunny‐day and rainy‐day scenarios, defines requirements for each use case, and decomposes each use case into a conceptual model‐view‐controller (MVC) pattern. PA also uses code generation from UML models to rapidly construct a domain‐driven microservice architecture at the inception of a project. This microservice architecture is then used to enable prototype code to interact with a live database during requirements definition. PA then uses automatic test case generation from the same UML model.The paper summarizes the overall challenge of software schedule compression, identifies managed parallel development as generally the most powerful but least‐practiced strategy for schedule compression, and summarizes the key elements required to support parallelism. It then summarizes the key techniques for scaling up PA, using a previous million‐line command and control project as an example.We have used MS‐degree graduate student projects to gather productivity data because the university environment has afforded us the opportunity to explore massively parallel development over an extended time period. We are now working with a large company to modernize their main legacy system using the PA methods. The prospective looks good as many of the techniques used (eg, domain models, use case analysis, and MVC decomposition) have been proven to be effective in industry on a wide range of projects for multiple decades. The new techniques (eg, executable domain models, and visual modeling of sprint plans) should also serve to make integration and project management work better on large development efforts.
Pitfall traps: A review of methods for estimating arthropod abundance
Authors: Hohbein Rhianna R. , Conway Courtney J. 
Published: December 2018

ABSTRACTPitfall traps are commonly used in diet studies for insectivorous and omnivorous wildlife. Pitfall trap methodologies and designs vary considerably among studies and investigators. Such variation and lack of standardization limits scientists’ abilities to compare their results with others. We conducted a literature review to identify the most common methods used by past investigators who placed pitfall traps for the purpose of quantifying indices of arthropod abundances, and used this information to guide our proposal for standardized pitfall trapping methods. We documented the pitfall‐trap methods of 257 studies published between January 1994 and March 2016 in 107 scientific journals. Pitfall‐trap methods varied greatly across the time period. We found only minor differences in the pitfall‐trap methods most commonly used in different vegetation communities (e.g., preservative was used less frequently for pitfall trap studies in grasslands). Studies published in wildlife journals tended to use pitfall traps of larger diameters than studies published in other disciplines; these studies also had worse rates of methodological reporting than those in entomology journals. We did not detect a decline in negligent reporting over time; ≥1 key methodological detail was missing from >50% of studies regardless of the decade published. Published 2018. This article is a U.S. Government work and is in the public domain in the USA.
The Material Manifestations of Regional Culture
Authors: Naquin Susan 
Published: December 2018

AbstractThis essay explores the non-luxury materialities through which most people experienced the world, argues for the possibilities of a geographically based view of Ming and Qing material history, and demonstrates some methods for approaching hard-to-find sources. It is my contention that not only will learning about and paying attention to such regional materialities open up new areas of research, but historians will also become better equipped to assess what we think we know about “China.” Here, I will concentrate on the geologically homogeneous region of the Greater North China Plain and focus on temple buildings, ritual vessels, and images of gods.
Evidence that abrasion can govern snow kinetic friction
Authors: LEVER JAMES H. , TAYLOR SUSAN , HOCH GARRETT R. , DAGHLIAN CHARLES 
Published: December 2018

ABSTRACTThe long-accepted theory to explain why snow is slippery postulates self-lubrication: frictional heat from sliding melts and thereby lubricates the contacting snow grains. We recently published micro-scale interface observations that contradicted this explanation: contacting snow grains abraded and did not melt under a polyethylene slider, despite low friction values. Here we provide additional observational and theoretical evidence that abrasion can govern snow kinetic friction. We obtained coordinated infrared, visible-light and scanning-electron micrographs that confirm that the evolving shapes observed during our tribometer tests are contacting snow grains polished by abrasion, and that the wear particles can sinter together and fill the adjacent pore spaces. Furthermore, dry-contact abrasive wear reasonably predicts the evolution of snow-slider contact area, and sliding-heat-source theory confirms that contact temperatures would not reach 0°C during our tribometer tests. Importantly, published measurements of interface temperatures also indicate that melting did not occur during field tests on sleds and skis. Although prevailing theory anticipates a transition from dry to lubricated contact along a slider, we suggest that dry-contact abrasion and heat flow can prevent this transition from occurring for snow-friction scenarios of practical interest.
Neogene Pectinidae (Bivalvia) of tribe Chlamydini Teppner, 1922 in Patagonia (Argentina):ZygochlamysIhering, 1907 and three new genera
Authors: Santelli María B. , del Río Claudia J. 
Published: December 2018

AbstractZygochlamysIhering, 1907 is revised and three new genera of tribe Chlamydini are named: the monospecific early Miocene generaPixiechlamysnew genus (type species:Pecten quemadensisIhering, 1897) andChokekenian. gen. (type species:Zygochlamys nicolasiMorra, 1985), and the late Miocene–early PlioceneMoirechlamysn. gen., containingPecten actinodesSowerby, 1846 (type species) andChlamys auroraeFeruglio, 1954.Zygochlamysis restricted to includeZ. geminata(Sowerby, 1846) (type species),Z. jorgensisIhering, 1907, andZ. sebastianiMorra, 1985. The present analysis increases the biostratigraphic usefulness of the group and improves taxonomic knowledge of the Neogene molluscan assemblages defined previously for Patagonia.Zygochlamys geminatais confined to the latest Oligocene–early Miocene interval of the Austral Basin of Patagonia (Argentina) and to the early Miocene of Chile,Z. jorgensisis restricted to the early to middle Miocene of the Golfo San Jorge and northern Austral Basins, andMoirechlamysn. gen., the most widespread genus, occurs in the late Miocene–early Pliocene of the Austral, Golfo San Jorge, Valdés, and Colorado basins. All these genera are endemic to southern South America;Zygochlamysis not related to other circumpolar genera such asAustrochlamysJonkers, 2003 orPsychrochlamysJonkers, 2003, rejecting its dispersal in the Antarctic Circumpolar Current, as has been proposed previously.UUID:http://zoobank.org/55d7ea85-5ec5-477a-9ede-5d3d795b75b5