bluuebunny/crossref_metadata_2025_split huggingface dataset:
Transport pathways shape the biogeography of alien freshwater fishes in Australia
Authors: García‐Díaz Pablo , Kerezsy Adam , Unmack Peter J. , Lintermans Mark , Beatty Stephen J. , Butler Gavin L. , Freeman Rob , Hammer Michael P. , Hardie Scott , Kennard Mark J. , Morgan David L. , Pusey Bradley J. , Raadik Tarmo A. , Thiem Jason D. , Whiterod Nick S. , Cassey Phillip , Duncan Richard P. 
Published: May 2018

AbstractAimChanging preferences regarding which species humans have transported to new regions can have major consequences for the potential distribution of alien taxa, but the mechanisms shaping these patterns are poorly understood. We assessed the extent to which changes in human preferences for transporting and introducing alien freshwater fishes have altered their biogeography.LocationAustralia.MethodsWe compiled an up‐to‐date database of alien freshwater fishes established in drainages in Australia before and after the number of established alien fish species doubled (pre‐1970 and post‐1970, respectively). Using metacommunity models, we analysed the influence of species traits and drainage features on the distribution of alien fishes that established pre‐ and post‐1970.ResultsAlien fishes in Australia were introduced via four main transport pathways: acclimatization, aquaculture, biocontrol and ornamental trade. The relative importance of each pathway changed substantially between the two periods, accompanied by changes in the distribution of alien fishes and the variables predicting their distribution. Pre‐1970, most species (64%) were introduced by acclimatization societies for purposes such as angling and biocontrol, and these fish have established in inland drainages more heavily impacted by human activities. In contrast, most of the post‐1970 introductions (69%) were ornamental fishes, with most species established in small, north‐eastern, tropical and subtropical coastal drainages.Main conclusionsSubstantial changes in introduction preferences and transport pathways over time have altered both the patterns and underlying processes shaping the biogeography of alien fishes in Australia. Our findings highlight the need for caution when using historical data to infer potential future distributions of alien species. The continuing spread of alien species means traditional biogeographical units may no longer be identifiable in the foreseeable future.
Bureaucratic manoeuvres and the local politics of climate change mitigation in China and India
Authors: Harrison Tom , Kostka Genia 
Published: May 2018

ABSTRACTThis article explores how strategies of thinking and working politically are used by agencies within developing country governments to influence wider government agendas. It uses research on climate change mitigation in China and India to explore how government agencies seek to overcome challenges of limited capacity and competing priorities by bundling climate change together with more immediate priorities and thereby developing a coalition with an interest in achieving these objectives. The article is based on interviews conducted in China and India, as well as analysis of themes covered in the growing body of literature on the domestic politics of climate change mitigation. In both countries we found that pragmatic approaches leveraging what already exists made significant progress in putting energy efficiency on the agenda, strengthening institutional presence (in India) and delivering improvements in energy efficiency (in China). Yet, we also found that the use of these tactics had significant limitations. While there was probably no other way that the policy space given to climate change mitigation could have increased so rapidly, there are significant side effects that arise as a result of the traction gained by these initial policy approaches. While bundling raised the profile of energy efficiency, it also created perverse incentives that highlight the need to consider the long‐term effect on the interests, capacity and sustainability of informal coalitions. We highlight the need to take account of both the short‐ and long‐term effects of thinking and working politically, and the challenges of doing so when the outcomes are unpredictable and inherently difficult to assess.
Sudden cardiac death in athletes and the value of cardiovascular magnetic resonance
Authors: Mavrogeni Sophie I. , Bacopoulou Flora , Apostolaki Despoina , Chrousos George P. 
Published: May 2018

AbstractSudden cardiac death (SCD) is the nontraumatic death, due to loss of heart function that occurs suddenly and unexpectedly within 6 hours of a previously normal state of health. It is related to intense competitive sports promoting ventricular tachycardia (VT)/ventricular fibrillation (VF) in the presence of underlying abnormal substrate. A serial evaluation of cardiac physiologic changes taking place during training will allow the better understanding of athlete's heart and will facilitate its discrimination from other grey‐zone cardiomyopathies. According to the ESC recommendations, a pre‐participation evaluation should include medical history, physical examination as well as a 12‐lead electrocardiogram (ECG). Additional tests, such as echocardiography, 24‐hours Holter monitoring, stress testing and cardiovascular magnetic resonance (CMR) should be requested upon positive findings at the initial evaluation. Cardiovascular magnetic resonance can be of great value in the differential diagnosis between various cardiomyopathies including hypertrophic cardiomyopathy (HCM), arrhythmogenic right ventricular cardiomyopathy (ARVC), left ventricle noncompaction cardiomyopathy (LVNC) and athlete's heart. This is due to its great versatility that can provide reliable and reproducible anatomical, functional and tissue characterization information, which are operator and acoustic window independent.
Modern approaches for early detection of forest pathogens are sorely needed in the United States
Authors: Munck Isabel A. , Bonello Pierluigi 
Published: May 2018

AbstractCurrent plant regulatory protocols rely on lists of known pathogens, but many forest pathogens are unknown. Live plants are inspected at port of entry for disease symptoms, but many plant pathogens can persist asymptomatically. Current efforts should be expanded by including random sampling of both symptomatic and asymptomatic plant tissues. Molecular probes and standardized protocols could be developed for invasive forest pathogens of most concern to the United States. High‐throughput sequencing (also known as next‐generation sequencing, or NGS) and bioinformatics could be used to identify potential pathogens in plant and soil samples collected at ports of entry from sentinel trees planted abroad, or in biosurveillance efforts. If potentially invasive forest pathogens were to be identified at ports of entry, sentinel trees, or with biosurveillance, this information must be shared with agencies that conduct forest health monitoring surveys beyond ports of entry.
Effect of deferasirox + erythropoietin vs erythropoietin on erythroid response in Low/Int‐1‐risk MDS patients: Results of the phase II KALLISTO trial
Authors: Gattermann Norbert , Coll Rosa , Jacobasch Lutz , Allameddine Allameddine , Azmon Amin , DeBonnett Laurie , Bruederle Andreas , Jin Jie ,   the KALLISTO study investigators
Published: May 2018

AbstractObjectivesErythropoiesis‐stimulating agents (ESAs) remain first‐choice to treat symptomatic anemia and delay transfusion dependence in most patients with lower‐risk myelodysplastic syndromes (MDS) without del(5q). Deferasirox increased erythroid responses in some lower‐risk MDS patients in clinical trials, and adding low‐dose deferasirox to ESA treatment may further improve erythroid response.MethodsKALLISTO (NCT01868477) was a randomized, open‐label, multicenter, phase II study. Lower‐risk MDS patients received deferasirox at 10 mg/kg/d (dispersible tablets) or 7 mg/kg/d (film‐coated tablets) plus erythropoietin (n = 11), or erythropoietin alone (n = 12) for 24 weeks. The primary endpoint was the between‐group difference in erythroid response within 12 weeks.ResultsErythroid response occurred in 27.3% of patients receiving deferasirox plus erythropoietin vs 41.7% of patients receiving erythropoietin alone within 12 weeks (difference 14.4%; 95% CI −24.0, 48.16). Within 24 weeks, the hematologic response rate was 27.3% with deferasirox plus erythropoietin vs 50% with erythropoietin alone, and hematologic improvement rates were 45.5% vs 100%. Deferasirox plus erythropoietin was generally well tolerated.ConclusionsIn this small pilot study, combining low‐dose deferasirox with erythropoietin did not improve erythroid response. It remains of interest to investigate early chelation approaches with even lower deferasirox doses plus erythropoietin in lower‐risk MDS patients before the onset of transfusion dependence.
Intra‐specific relatedness, spatial clustering and reduced demographic performance in tropical rainforest trees
Authors: Shao Xiaona , Brown Calum , Worthy Samantha J. , Liu Lu , Cao Min , Li Qiaoming , Lin Luxiang , Swenson Nathan G. 
Published: May 2018

AbstractIntra‐specific negative density dependence promotes species coexistence by regulating population sizes. Patterns consistent with such density dependence are frequently reported in diverse tropical tree communities. Empirical evidence demonstrating whether intra‐specific variation is related to these patterns, however, is lacking. The present study addresses this important knowledge gap by genotyping all individuals of a tropical tree in a long‐term forest dynamics plot in tropical China. We show that related individuals are often spatially clustered, but having closely related neighbours reduces the growth performance of focal trees. We infer from the evidence that dispersal limitation and negative density dependence are operating simultaneously to impact the spatial distributions of genotypes in a natural population. Furthermore, dispersal limitation decreases local intra‐specific genetic diversity and increases negative density dependence thereby promoting niche differences and species coexistence as predicted by theory.
Limited hatchery introgression into wild brook trout (Salvelinus fontinalis) populations despite reoccurring stocking
Authors: White Shannon L. , Miller William L. , Dowell Stephanie A. , Bartron Meredith L. , Wagner Tyler 
Published: May 2018

AbstractDue to increased anthropogenic pressures on many fish populations, supplementing wild populations with captive‐raised individuals has become an increasingly common management practice. Stocking programs can be controversial due to uncertainty about the long‐term fitness effects of genetic introgression on wild populations. In particular, introgression between hatchery and wild individuals can cause declines in wild population fitness, resiliency, and adaptive potential and contribute to local population extirpation. However, low survival and fitness of captive‐raised individuals can minimize the long‐term genetic consequences of stocking in wild populations, and to date the prevalence of introgression in actively stocked ecosystems has not been rigorously evaluated. We quantified the extent of introgression in 30 populations of wild brook trout (Salvelinus fontinalis) in a Pennsylvania watershed and examined the correlation between introgression and 11 environmental covariates. Genetic assignment tests were used to determine the origin (wild vs. captive‐raised) for 1,742 wild‐caught and 300 hatchery brook trout. To avoid assignment biases, individuals were assigned to two simulated populations that represented the average allele frequencies in wild and hatchery groups. Fish with intermediate probabilities of wild ancestry were classified as introgressed, with threshold values determined through simulation. Even with reoccurring stocking at most sites, over 93% of wild‐caught individuals probabilistically assigned to wild origin, and only 5.6% of wild‐caught fish assigned to introgressed. Models examining environmental drivers of introgression explained <3% of the among‐population variability, and all estimated effects were highly uncertain. This was not surprising given overall low introgression observed in this study. Our results suggest that introgression of hatchery‐derived genotypes can occur at low rates, even in actively stocked ecosystems and across a range of habitats. However, a cautious approach to stocking may still be warranted, as the potential effects of stocking on wild population fitness and the mechanisms limiting introgression are not known.
Population genomics of the introduced and cultivated Pacific kelp Undaria pinnatifida: Marinas—not farms—drive regional connectivity and establishment in natural rocky reefs
Authors: Guzinski Jaromir , Ballenghien Marion , Daguin‐Thiébaut Claire , Lévêque Laurent , Viard Frédérique 
Published: May 2018

AbstractPorts and farms are well‐known primary introduction hot spots for marine non‐indigenous species (NIS). The extent to which these anthropogenic habitats are sustainable sources of propagules and influence the evolution of NIS in natural habitats was examined in the edible seaweed Undaria pinnatifida, native to Asia and introduced to Europe in the 1970s. Following its deliberate introduction 40 years ago along the French coast of the English Channel, this kelp is now found in three contrasting habitat types: farms, marinas and natural rocky reefs. In the light of the continuous spread of this NIS, it is imperative to better understand the processes behind its sustainable establishment in the wild. In addition, developing effective management plans to curtail the spread of U. pinnatifida requires determining how the three types of populations interact with one another. In addition to an analysis using microsatellite markers, we developed, for the first time in a kelp, a ddRAD‐sequencing technique to genotype 738 individuals sampled in 11 rocky reefs, 12 marinas, and two farms located along ca. 1,000 km of coastline. As expected, the RAD‐seq panel showed more power than the microsatellite panel for identifying fine‐grained patterns. However, both panels demonstrated habitat‐specific properties of the study populations. In particular, farms displayed very low genetic diversity and no inbreeding conversely to populations in marinas and natural rocky reefs. In addition, strong, but chaotic regional genetic structure, was revealed, consistent with human‐mediated dispersal (e.g., leisure boating). We also uncovered a tight relationship between populations in rocky reefs and those in nearby marinas, but not with nearby farms, suggesting spillover from marinas into the wild. At last, a temporal survey spanning 20 generations showed that wild populations are now self‐sustaining, albeit there was no evidence for local adaptation to any of the three habitats. These findings highlight that limiting the spread of U. pinnatifida requires efficient management policies that also target marinas.
Conceptualizing cultural literacy through student learning outcomes assessment
Authors: Barrette Catherine M. , Paesani Kate 
Published: May 2018

AbstractStudent learning outcomes (SLO) assessment is often perceived as a burdensome, top‐down process driven by institutional requirements. Recent research has thus called for discipline‐specific models of SLO assessment to more deeply engage postsecondary faculty in determining what constitutes student learning within their programs. In response, this article presents a recursive process of developing and applying a model of cultural literacy to SLO assessment documents from one foreign language (FL) department comprising multiple BA programs. The study has two interrelated parts: (1) operationalizing the concept of cultural literacy, and (2) analyzing assessment documents using qualitative content analysis. Findings show that cultural literacy is characterized by eight unique factors evident across FL program assessment documents to varying degrees. This measurable definition of cultural literacy can facilitate the alignment of goals and outcomes with disciplinary principles and has implications for curriculum development and instructional practices in collegiate FL programs.
Vegetation growth enhancement in urban environments of the Conterminous United States
Authors: Jia Wenxiao , Zhao Shuqing , Liu Shuguang 
Published: May 2018

AbstractCities are natural laboratories for studying vegetation responses to global environmental changes because of their climate, atmospheric, and biogeochemical conditions. However, few holistic studies have been conducted on the impact of urbanization on vegetation growth. We decomposed the overall impacts of urbanization on vegetation growth into direct (replacement of original land surfaces by impervious built‐up) and indirect (urban environments) components, using a conceptual framework and remotely sensed data for 377 metropolitan statistical areas (MSAs) in the conterminous United States (CONUS) in 2001, 2006, and 2011. Results showed that urban pixels are often greener than expected given the amount of paved surface they contain. The vegetation growth enhancement due to indirect effects occurred in 88.4%, 90.8%, and 92.9% of urban bins in 2001, 2006, and 2011, respectively. By defining offset value as the ratio of the absolute indirect and direct impact, we obtained that growth enhancement due to indirect effects compensated for about 29.2%, 29.5%, and 31.0% of the reduced productivity due to loss of vegetated surface area on average in 2001, 2006, and 2011, respectively. Vegetation growth responses to urbanization showed little temporal variation but large regional differences with higher offset value in the western CONUS than in the eastern CONUS. Our study highlights the prevalence of vegetation growth enhancement in urban environments and the necessity of differentiating various impacts of urbanization on vegetation growth, and calls for tailored field experiments to understand the relative contributions of various driving forces to vegetation growth and predict vegetation responses to future global change using cities as harbingers.
Core outcome set for gene therapy in haemophilia: Results of the coreHEM multistakeholder project
Authors: Iorio A. , Skinner M. W. , Clearfield E. , Messner D. , Pierce G. F. , Witkop M. , Tunis S. ,   the coreHEM panel
Published: May 2018

BackgroundGene therapy trial results show potential to cure haemophilia A and haemophilia B. Securing broad access to a cure for a lifelong chronic disease is anticipated to face barriers at the individual and healthcare system levels, which can be partly mitigated by harmonized planning of clinical research studies. The aim of the coreHEM project was to determine the set of outcome measures required to evaluate efficacy, safety, comparative effectiveness and value of gene therapy for haemophilia.MethodsModified Delphi consensus process, based on methods adapted from the COMET Initiative.ResultsForty‐nine participants (five patients, five clinicians, five researchers, four regulators, three research agencies, six health technology assessors, nine payers and 12 drug developers) took part in the study, with over 90% participation. The frequency of bleeds, factor activity level, duration of expression, chronic pain, healthcare resource use and mental health were identified as the core outcomes to be measured in addition to regulatory‐mandated adverse effects.ConclusionsFor the first time in haemophilia, a core outcome set has been developed, with the involvement of representatives of all relevant stakeholder groups. The core set has been expanded to include outcomes supporting assessment of comparative effectiveness and value, with the goal of streamlining regulatory approval, health technology assessment and market access decisions. Patient involvement ensures that outcomes are meaningful and relevant to those living with haemophilia. Active dialogue among drug developers, regulators and payers throughout the process is expected to facilitate broad uptake of the core outcomes in forthcoming clinical trials.
Regenerative endodontics: a comprehensive review
Authors: Kim S. G. , Malek M. , Sigurdsson A. , Lin L. M. , Kahler B. 
Published: May 2018

AbstractThe European Society of Endodontology and the American Association for Endodontists have released position statements and clinical considerations for regenerative endodontics. There is increasing literature on this field since the initial reports of Iwaya et al. (Dental Traumatology, 17, 2001, 185) and Banchs & Trope (Journal of Endodontics, 30, 2004, 196). Endogenous stem cells from an induced periapical bleeding and scaffolds using blood clot, platelet rich plasma or platelet‐rich fibrin have been utilized in regenerative endodontics. This approach has been described as a ‘paradigm shift’ and considered the first treatment option for immature teeth with pulp necrosis. There are three treatment outcomes of regenerative endodontics; (i) resolution of clinical signs and symptoms; (ii) further root maturation; and (iii) return of neurogenesis. It is known that results are variable for these objectives, and true regeneration of the pulp/dentine complex is not achieved. Repair derived primarily from the periodontal and osseous tissues has been shown histologically. It is hoped that with the concept of tissue engineering, namely stem cells, scaffolds and signalling molecules, that true pulp regeneration is an achievable goal. This review discusses current knowledge as well as future directions for regenerative endodontics. Patient‐centred outcomes such as tooth discolouration and possibly more appointments with the potential for adverse effects needs to be discussed with patients and parents. Based on the classification of Cvek (Endodontics and Dental Traumatology, 8, 1992, 45), it is proposed that regenerative endodontics should be considered for teeth with incomplete root formation although teeth with near or complete root formation may be more suited for conventional endodontic therapy or MTA barrier techniques. However, much is still not known about clinical and biological aspects of regenerative endodontics.
“The Evolution of Eyebrow Morphology: The Westmore Model Revisited”
Authors: Jabbour Samer , Nasr Marwan , Kechichian Elio , Aderian Sandrine S. , Nseir Iad , Levan Philippe , Noel Warren 
Published: May 2018

AbstractBackgroundThe most widely recognized eyebrow model was described by Westmore in 1974. With the rapidly changing concept of beauty, an accurate up‐to‐date model is needed.MethodsThe Westmore model was tested on fashion models that were randomly selected from the covers of the 1965–1975 (group 1) and 2006–2016 (group 2) Vogue magazine. The eyebrows of fashion models, which represent the beauty ideals of these decades, were objectively measured and compared. We proposed a modified eyebrow model more adapted to the modern standards of beauty, applied it to group 2, and objectively compared it to the Westmore model. This new model was validated on a group of randomly selected Caucasian women.ResultsThirty women were included in each group. The medial edge of the eyebrow was better defined by the Westmore model in group 1 compared to group 2. The lateral edge of the eyebrow was better defined by the Westmore model in group 2. The peak of the eyebrow was not well defined by the Westmore model in both groups. The new model was more adapted than the Westmore model for both the medial edge and the peak of the eyebrow in group 2. It was also accurate in non‐model Caucasian women.ConclusionEyebrow morphology has evolved since the description of the Westmore model. Our model represents a simple way to accurately predict the eyebrow landmarks according to the modern ideals of beauty.