bluuebunny/crossref_metadata_2025_split huggingface dataset:
Working life expectancy in good and poor self-perceived health among Dutch workers aged 55–65 years with a chronic disease over the period 1992–2016
Authors: de Wind Astrid , van der Noordt Maaike , Deeg Dorly J H , Boot Cecile R L 
Published: September 2018

ObjectivesSeveral governments have taken measures to encourage prolonged working. It is therefore likely that older adults with a chronic disease are required to work longer in poor self-perceived health (SPH) than before. This study examines to what extent working life expectancy (WLE) in good and poor SPH changed between 1992 and 2016 in workers with a chronic disease from age 55 years onwards.MethodsThree cohorts (1992, 2002 and 2012) of workers with a chronic disease aged 55–65 years were selected from the Longitudinal Aging Study Amsterdam with a 3-year follow-up each (n=705). A three-state survival model was estimated, modelling transitions between states ‘working with good SPH’, ‘working with poor SPH’ and ‘exit from work’. WLEs were estimated using Multistate Modelling and Estimating Life Expectancies using Continuous Time in R.ResultsOf the workers with a chronic disease, total WLEs at age 55 years were 5.2, 5.7 and 6.8 years in cohorts 1992, 2002 and 2012, respectively. Workers initially having poor SPH, had total WLE of 4.7 years of which 2.4 years in poor SPH in cohort 1992. These workers had total WLE of 5.2 years of which 3.3 years in poor SPH in cohort 2002, and total WLE of 6.5 years of which 3.6 years in poor SPH in cohort 2012.ConclusionsWorkers with a chronic disease extended their working lives by approximately 18 months from 1992 to 2016. In the first decade, unhealthy WLE increased, whereas in the second decade, healthy WLE increased, among both workers in general and workers initially having poor SPH.
Mitigation of Wind-Induced Vibration of a 600m High Skyscraper
Authors: Zhang J. W. , Li Q. S. 
Published: September 2018

The serviceability of super-tall buildings depends primarily on the wind-induced structural responses, especially accelerations. To mitigate the discomforting structural vibrations, pendulum-type tuned mass damper (TMD) systems are commonly employed in high-rise buildings. However, for a super-tall building with a considerably low fundamental natural frequency, the suspension length of a pendulum-suspended TMD (PTMD) becomes too long to be feasible as it would occupy substantial building space. For the sake of saving valuable space in a super-tall building, a multistage PTMD system is recommended for vibration control. This paper presents a detailed assessment study on the performance of a multistage PTMD system designed for a 600 m high skyscraper located in a typhoon-prone region in China. Wind tunnel tests are first conducted to determine the wind loads on the building for estimation of structural dynamic responses for the scenarios with and without installation of the multistage PTMD system. Optimal design of the multistage PTMD system is then carried out through examining the mitigation efficiency of the PTMD system for a variety of mass and damping ratios. To restrict the strokes of mass dampers in the PTMD system, two-section damping strategy is proposed. The assessment results demonstrate that the multistage PTMD system with two-section damping can function efficiently to suppress the excessive vibrations of the skyscraper, while occupying a minimal space in vertical and horizontal directions. This paper aims to provide an effective and economic design strategy for vibration control of super-tall buildings under wind excitations.
Predictions of the wetting of bentonite emplaced in a crystalline rock based on generic site characterization data
Authors: Baxter S. , Holton D. , Williams S. , Thompson S. 
Published: September 2018

Abstract
A geological disposal facility (GDF) is the widely accepted long-term solution for the management of higher-activity radioactive waste. It consists of an engineered facility constructed in a suitable host rock. The facility is designed to inhibit the release of radioactivity by using a system consisting of engineered and natural barriers. The engineered barriers include the wasteform, used to immobilize the waste, the waste disposal container and any buffer material used to protect the container. The natural barrier includes the rocks in which the facility is constructed. The careful design of this multi-barrier system enables the harmful effects of the radioactivity on humans and biota in the surface environment to be reduced to safe levels.
Bentonite is an important buffer material used as a component of a multi-barrier disposal system. For example, compacted bentonite rings and blocks are used to protect the copper container, used for the disposal of spent fuel, in the KBS-3 disposal system. As the bentonite saturates, through contact with groundwater from the host rock, it swells and provides a low hydraulic conductivity barrier, enabling the container to be protected from deleterious processes, such as corrosion. The characteristic swelling behaviour of bentonite is due to the presence of significant quantities of sodium montmorillonite.

Recently, there have been detailed
in situ
experiments designed to understand how bentonite performs under natural conditions. One such experiment is the Buffer–Rock Interaction Experiment (BRIE), performed at the Äspö Hard Rock Laboratory near Oskarshamn in the SE of Sweden. This experiment is designed to further understand the wetting of bentonite from the groundwater flow in a fractured granite host rock.

In this paper, the observations from the BRIE are explained using an integrated model that is able to describe the saturation of bentonite emplaced in a heterogeneous fractured rock. It provides a framework to understand the key processes in both the rock and bentonite. The predictive capability of these models was investigated within the context of uncertainties in the data and the consequence for predictions of the wetting of emplaced bentonite. For example, to predict the wetting of emplaced bentonite requires an understanding of the distribution of fracture transmissivity intersecting the bentonite. A consequence of these findings is that the characterization of the fractured rock local to the bentonite is critical to understanding the subsequent wetting profiles. In particular, prediction of the time taken to achieve full saturation of bentonite using a simplified equivalent homogeneous description of the fractured host rock will tend to be too short.
Successful Treatment of HIV-Associated Kaposi Sarcoma with Immune Checkpoint Blockade
Authors: Galanina Natalie , Goodman Aaron M. , Cohen Philip R. , Frampton Garrett M. , Kurzrock Razelle 
Published: September 2018

Abstract
Kaposi sarcoma (KS) is an incurable, human immunodeficiency virus (HIV)-associated malignancy. We reviewed 320 immunotherapy-treated patient records. Seventeen had HIV-associated malignancies, including nine men with KS. Median viral load was 20 copies/mL (range, undetectable to 549,704) and median CD4 count was 256 cells/μL (range, 10–603). Eight patients received nivolumab and one received pembrolizumab. Six patients (67%) achieved partial (N = 5) or complete remission (N = 1). No drug-related grade &gt;2 toxicities occurred. In seven patients, CD4 counts increased (P = 0.09). Tissue and/or blood-derived circulating tumor DNA (ctDNA) was evaluated by next-generation sequencing. Four evaluable patients each showed anomalies in distinct genes: TP53, KRAS, TLL2, PTPN6 (tissue and/or ctDNA), and NF1 (ctDNA). Tumor mutational burden was low, and PD-L1 immunohistochemistry was negative (three and four assessable patients, respectively). Responders included patients with low CD4 counts, high HIV load, and/or visceral disease. In summary, checkpoint blockade demonstrated significant antitumor activity and low toxicity in patients with HIV-associated KS. Cancer Immunol Res; 6(10); 1129–35. ©2018 AACR.
КОМОРБІДНІСТЬ ТА ЇЇ ВПЛИВ НА ПРИХИЛЬНІСТЬ ДО ПОДАЛЬШОГО ЛІКУВАННЯ У ПАЦІЄНТІВ З ІНФАРКТОМ МІОКАРДА
Authors: Levchyk O. I. 
Published: September 2018

In modern clinical practice, the doctor is increasingly faced with a combination of two or more diseases in one patient. Such states are called comorbid, concomitant pathologies, or associated diseases [1–3]. This is especially true for patients with myocardial infarction (MI), since cardiovascular disease (CVD ) remains one of the main causes of death in Ukraine and in the world (World Heart Federation, WH F, 2017).The aim of the study – to set the frequency and the structure of comorbidity in patients with myocardial infarction (IM) and its effect on adherence to further treatment.Materials and Methods. We examined 152 patients with MI, aged 38 to 89 years, on average (60.66±0.86) years (52 women and 100 men) who were divided according to the Morisky-Green questionnaire by two groups: the first – adherent to treatment (n=77), the second group – not adherent to treatment (n=75). The Charlson and CIRS comorbidity indices were determined.Results and Discussion. Both groups identified risk factors and 84% of the concomitant pathology, with the Charleston index – (5.81±1.78), and CIRS (9.32±2.79) points, the largest proportion of diseases of the digestive system. When comparing between groups for the same amount of comorbid pathology (5.66±0.19) and (5.96±0.24) points of Charlson, p<0.05) in patients in the second group a heavier course with deeper damage to organs and systems (CIRS – (8.23±0.25) versus (10.43±0.34) points, p<0.001), which reduces the level of adherence to the prescribed therapy.Conclusions. Patients with myocardial infarction often have a comorbidity, but with the same number of concomitant diseases in different patients, the severity and depth of damage to organs and systems are different. The present combined pathology has an effect on adherence to therapy. Determining the Charlson and CIRS indices allows you to predict the level of compliance individually for each patient and take measures to increase its level.
Gerard Manley Hopkins and Ruskin’s Idea of the Christian Artist
Authors: Ward Bernadette Waterman 
Published: September 2018

Abstract
John Ruskin gave Gerard Manley Hopkins an aesthetic vocabulary imbued with Christian concepts of obedience, sacrifice, truth, and Divine Beauty. Even secular art is never morally neutral; Christian art has additional moral weight in the artist’s reverence for God’s self-revelation in creation. Hopkins’s Scotism confirmed his conviction that an artist’s work must be a responsible personal proclamation of truth about creation. Such moral responsibility discourages easy sentimentality but demands reverence for beauty. The depth of Hopkins’s interaction with etymology, syntax, and sound springs from Ruskinian sacrificial expenditure of workmanship and reverence for what Ruskin called “truth” to materials. “Ashboughs,” a cheerful, subtly Marian curtal sonnet, shows Hopkins’s Ruskinian principles at work late in his life, especially in the poet’s attention to diction, syntax, and divine truth revealed in concrete, worldly beauty.
“Most Active and Effectual Assistance” in the Correspondence of Sir William Dugdale and William Somner
Authors: Fletcher Rachel 
Published: September 2018

AbstractIn theDictionarium Saxonico-Latino-Anglicum(1659), the first published dictionary of Old English, its compiler, William Somner (?1606–1669), expresses his gratitude for the “most active and effectual assistance” of the herald and antiquary William Dugdale (1605–1686) in bringing the work to publication. However, this brief mention conveys little about the long-standing working relationship between the two men, which was already in place when Somner began work on theDictionariumand which continued after its publication. The author shows how surviving correspondence can help build a fuller picture, drawing on letters frequently cited in connection with theDictionariumalongside less discussed material. This article situates Dugdale’s “active and effectual assistance” with theDictionariumin the wider context of the antiquarian interests and projects he shared with Somner. In doing so, it also demonstrates how each of the two men was able to contribute his own expertise and resources to the work of the other. As such, this article emphasises both the importance of such collaboration for the development of Old English studies in the seventeenth century and the significant overlap in this period between linguistic investigation and broader antiquarian activities.
Digital Video Laryngoscopy and Flexible Endoscopic Biopsies as an Alternative Diagnostic Workup in Laryngopharyngeal Cancer: A Prospective Clinical Study
Authors: Schutte Henrieke W. , Takes Robert P. , Slootweg Piet J. , Arts Marianne J.P.A. , Honings Jimmie , van den Hoogen Frank J.A. , Marres Henri A.M. , van den Broek Guido B. 
Published: September 2018

Objectives: An office-based workup strategy for patients with laryngopharyngeal lesions suspicious for carcinoma is analyzed. The feasibility of office-based transnasal flexible endoscopic biopsies under local anesthesia and the impact on the diagnostic workup are evaluated. Methods: This study is a prospective analysis of patients with laryngeal, oropharyngeal, and hypopharyngeal lesions suspicious for carcinoma. One hundred eighty-eight participants were divided into 2 groups. The first group underwent an office-based biopsy procedure under local anesthesia using a flexible digital video laryngoscope with instrument channel (n = 53), and the second group underwent a biopsy procedure under general anesthesia using rigid laryngopharyngoscopy (n = 135). Results: Office-based flexible endoscopic biopsies were tolerated well, and there were no complications. These biopsies were 92.5% successful in acquiring a definitive diagnosis. Costs were reduced. Diagnostic workup time and time until start of therapy were reduced to 2 days and 27 days, respectively. Conclusion: Office-based biopsy under local anesthesia using flexible digital video laryngoscopy is safe, cost-effective, and successful in providing a histopathological diagnosis. It reduces the diagnostic workup time significantly in patients with laryngeal, oropharyngeal, and hypopharyngeal cancer, while also reducing the necessity to subsequently perform a rigid laryngopharyngoscopy under general anesthesia.
Adjunctive Internet-delivered cognitive behavioural therapy for insomnia in men with depression: A randomised controlled trial
Authors: Glozier Nick , Christensen Helen , Griffiths Kathleen M , Hickie Ian B , Naismith Sharon L , Biddle Daniel , Overland Simon , Thorndike Frances , Ritterband Lee 
Published: September 2018

Objective: Internet-delivered cognitive behavioural therapy for insomnia is efficacious for insomnia, and post hoc analyses suggest mood improvements. We undertook the first clinical trial evaluating the efficacy of Internet-delivered cognitive behavioural therapy for insomnia on depressive symptoms as an adjunct to guideline-based treatment of depressive disorders. Methods: Older men undergoing psychiatrist-coordinated treatment for major depressive disorder or dysthymia and who had significant insomnia symptoms were randomised to either adjunctive Internet-delivered cognitive behavioural therapy for insomnia (Sleep Healthy Using The Internet) or online sleep psychoeducation. The primary outcome was change in depressive symptoms (Centre for Epidemiological Studies Depression scale) from baseline to week 12 (post intervention). Secondary outcomes were insomnia and anxiety symptoms. Results: In all, 87 men were randomised (Internet-delivered cognitive behavioural therapy for insomnia = 45; psychoeducation = 42). The mean observed Centre for Epidemiological Studies Depression scale changes by week 12 were 8.2 (standard deviation = 11.5) and 3.9 (standard deviation = 12.8) for Internet-delivered cognitive behavioural therapy for insomnia and psychoeducation, respectively. The adjunctive effect size of 0.35 in favour of Sleep Healthy Using The Internet programme was not statistically significant (group × time difference in the Mixed effect Model Repeat Measurement analysis difference 4.3; 95% confidence interval = [−1.2, 9.8]; p = 0.15). There was a statistically significant effect on insomnia symptoms (group × time p = 0.02, difference 2.7; 95% confidence interval = [0.2, 5.3]; effect size = 0.62). There were no differences in insomnia or depression at 6 months or differential effects on anxiety at any time point. There were no reported adverse trial-related events in the intervention arm. Conclusion: Adjunctive Internet-delivered cognitive behavioural therapy for insomnia for older men being treated for depression can improve insomnia in the short term, without apparent harm. The short-term depressive symptom effect size in this pilot trial was comparable to other adjunctive interventions and may warrant a larger, definitive trial.
Primary Energy Factors and the primary energy intensity of delivered energy: An overview of possible calculation conventions
Authors: Hitchin Roger 
Published: September 2018

The related concepts of Primary Energy and Primary Energy Factors (which describe how much Primary energy is contained in each unit of delivered energy) are used for international comparisons of national energy use and have become increasingly important regulatory and statistical metrics, especially in relation to the European Energy Performance of Buildings Directive. As concepts they contain a mixture of technical, political and economic dimensions, so it is perhaps unsurprising that reported values from different organisations and countries do not seem to be calculated in the same way. This review aims to clarify the origins of such differences by identifying, summarising and commenting on alternative conventions that are or can be applied. In particular, it aims to provide a starting point for the development of a transparent means of reporting the procedures and conventions that are employed. Such a framework would provide a basis for understanding the reasons for differences. The review does not recommend specific conventions or procedures – preferences will vary, depending on a number of factors. Practical application: Primary Energy Factors are central to international comparisons of national energy consumption and to several aspects of European energy policy. In the context of buildings, they are especially important to the newly revised Energy Performance of Buildings Directive which requires primary energy to be the primary metric, rather than, for example, carbon emissions. It is known that different countries use different methodologies and that this can have substantial repercussions. The methodologies used are rarely reported and range of possible options has not previously been set out. This paper sets out to do this in order so that choices can be made with greater transparency and clarity.
A Study on the Effect of Porous CaCO3 on Micro-Cellular Plastics as an Additive for Nucleation
Authors: Cha Sung W. , Yoon Jae D. , Uto Nariatsu 
Published: September 2018

Plastics are widely used in industry, in that they are light and easily manufactured. Much research is being conducted currently to increase the strengths and to reduce the price of the material. Foaming techniques are used to achieve insulation properties, to reduce weight, and to reduce the material cost. Due to their unique properties, foamed plastics are applied to refrigerator, pipe, and insulators. In 1980, Micro-cellular foaming was invented at MIT. By applying the outstanding foaming technique, many small cells are generated in the polymer matrices and micro-cellular foamed plastics show relatively high specific strength. We investigated the role of CaCO3, which is one of the most widely used additives in the plastics industry, for nucleation in view of cell morphology. Porous CaCO3 chemically treated to increase the dispersibility and to lower the density was used in this study. Two experiments were conducted in order to check the role of the additive for nucleation. One is the compound-ability test and the other is for the role as nucleation agents.
Cleanroom Insulation Performance of Nitrogen Expanded Low Density Polyvinylidene Fluoride (PVDF) Foams
Authors: Witten Neil 
Published: September 2018

Zotefoams plc is a world leading manufacturer of low density, closed-cell, crosslinked block foams and is recognised globally for producing the highest performance polyolefin foams. In recent years the company has developed a new generation of low density foams based on materials where foaming has traditionally been an insurmountable technical challenge or other limitations have existed to the reduction in density possible. One of these new commercially available foam products, sold under the trademark ZOTEK® F, is based on the fluoropolymer Polyvinylidene Fluoride (PVDF). The properties of the products, not surprisingly, reflect the general properties of the fluoropolymer family however as cellular materials the combination of material attributes is unsurpassed in the industry. This paper will describe these novel foam products covering the key aspects of the current commercial grades of ZOTEK® F and the technology used to manufacture them. The paper will then focus on a specific application area in cleanroom insulation, where the product performance will be reviewed against the combination of technically challenging requirements such as low flammability, low smoke generation, low thermal conductivity, low moisture absorption, chemical inertness and resistance to fungal growth.
Welding of Crosslinked Polyethylene Pipes
Authors: Tobias W. 
Published: September 2018

The butt-welding of pipes made of crosslinked polyethylene, the most efficient joining method for the material PE-X, which up to now has been regarded an ‘non-weldable’, will enable it to be used for industrial and underground pipes and hence will make a major contribution to state-of-the-art and future-orientated pipeline applications. In the future, it should also be possible to weld PE-X pipes with diameters of less than 90 mm and work is also being performed to develop welded joints with the same temperature resistance as the pipes. This will permit the use of welded PE-X pipes for hot-water systems and heating technology.
Effect of Chemical Modification of Poly(Butylene Terephthalate) on Elastic Properties
Authors: Ukielski R. , Lembicz F. 
Published: September 2018

It can be stated, on the basis of the investigations presented in this article, that chemical modification of the PBT chain as a result of introducing cheap and readily available modifying comonomers – PTMOG and DMI – with a view to improving the elastic and impact properties, achieved the intended results. Improvement of these characteristics while at the same time maintaining very good thermal and strength properties is obtained in the case of polymers 3, 7 and 8, i.e. PBT modified with DMI alone at 6 wt.%, with a system 6 wt.% DMI + 6 wt.% PTMOG or with PTMOG alone at 20 wt.%. These polymers are best at meeting the requirements of customers, especially manufacturers of domestic appliances.