bluuebunny/crossref_metadata_2025_split huggingface dataset:
Curcumin prevents the bile reflux‐induced NF‐κB‐related mRNA oncogenic phenotype, in human hypopharyngeal cells
Authors: Vageli Dimitra P. , Doukas Sotirios G. , Spock Todd , Sasaki Clarence T. 
Published: June 2018

AbstractThe presence of bile is not an uncommon finding in acidic oesophageal and extra‐oesophageal refluxate, possibly affecting the hypopharyngeal mucosa and leading to neoplastic events. We recently demonstrated that acidic bile (pH ≤ 4.0) can induce NF‐κB activation and oncogenic mRNA phenotype in normal hypopharyngeal cells and generate premalignant changes in treated hypopharyngeal mucosa. We hypothesize that curcumin, a dietary inhibitor of NF‐κB, may effectively inhibit the acidic bile‐induced cancer‐related mRNA phenotype, in treated human hypopharyngeal primary cells (HHPC), supporting its potential preventive use in vivo. Luciferase assay, immunofluorescence, Western blot, qPCR and PCR microarray analysis were used to explore the effect of curcumin in HHPC exposed to bile (400 μmol/L) at acidic and neutral pH. Curcumin successfully inhibited the acidic bile‐induced NF‐κB signalling pathway (25% of analysed genes), and overexpression of NF‐κB transcriptional factors, c‐REL, RELA(p65), anti‐apoptotic bcl‐2, oncogenic TNF‐α, EGFR, STAT3, WNT5A, ΔNp63 and cancer‐related IL‐6. Curcumin effectively reduced bile‐induced bcl‐2 overexpression at both acidic and neutral pH. Our novel findings suggest that, similar to pharmacologic NF‐κB inhibitor, BAY 11‐7082, curcumin can suppress acidic bile‐induced oncogenic mRNA phenotype in hypopharyngeal cells, encouraging its future in vivo pre‐clinical and clinical explorations in prevention of bile reflux‐related pre‐neoplastic events mediated by NF‐κB.
Circulating Tumor Cells Undergoing EMT Provide a Metric for Diagnosis and Prognosis of Patients with Hepatocellular Carcinoma
Authors: Qi Lu-Nan , Xiang Bang-De , Wu Fei-Xiang , Ye Jia-Zhou , Zhong Jian-Hong , Wang Yan-Yan , Chen Yuan-Yuan , Chen Zu-Shun , Ma Liang , Chen Jie , Gong Wen-Feng , Han Ze-Guang , Lu Yan , Shang Jin-Jie , Li Le-Qun 
Published: June 2018

Abstract
To clarify the significance of circulating tumor cells (CTC) undergoing epithelial–mesenchymal transition (EMT) in patients with hepatocellular carcinoma (HCC), we used an advanced CanPatrol CTC-enrichment technique and in situ hybridization to enrich and classify CTC from blood samples. One hundred and one of 112 (90.18%) patients with HCC were CTC positive, even with early-stage disease. CTCs were also detected in 2 of 12 patients with hepatitis B virus (HBV), both of whom had small HCC tumors detected within 5 months. CTC count ≥16 and mesenchymal–CTC (M-CTC) percentage ≥2% prior to resection were significantly associated with early recurrence, multi-intrahepatic recurrence, and lung metastasis. Postoperative CTC monitoring in 10 patients found that most had an increased CTC count and M-CTC percentage before clinically detectable recurrence nodules appeared. Analysis of HCC with high CTC count and high M-CTC percentage identified 67 differentially expressed cancer-related genes involved in cancer-related biological pathways (e.g., cell adhesion and migration, tumor angiogenesis, and apoptosis). One of the identified genes, BCAT1, was significantly upregulated, and knockdown in Hepg2, Hep3B, and Huh7 cells reduced cell proliferation, migration, and invasion while promoting apoptosis. A concomitant increase in epithelial marker expression (EpCAM and E-cadherin) and reduced mesenchymal marker expression (vimentin and Twist) suggest that BCAT1 may trigger the EMT process. Overall, CTCs were highly correlated with HCC characteristics, representing a novel marker for early diagnosis and a prognostic factor for early recurrence. BCAT1 overexpression may induce CTC release by triggering EMT and may be an important biomarker of HCC metastasis.
Significance: In liver cancer, CTC examination may represent an important “liquid biopsy” tool to detect both early disease and recurrent or metastatic disease, providing cues for early intervention or adjuvant therapy. Cancer Res; 78(16); 4731–44. ©2018 AACR.
Clinical Relevance and Suppressive Capacity of Human Myeloid-Derived Suppressor Cell Subsets
Authors: Lang Stephan , Bruderek Kirsten , Kaspar Cordelia , Höing Benedikt , Kanaan Oliver , Dominas Nina , Hussain Timon , Droege Freya , Eyth Christian , Hadaschik Boris , Brandau Sven 
Published: June 2018

Abstract
Purpose: Myeloid-derived suppressor cells (MDSC) are a heterogeneous group of pathologically expanded myeloid cells with immunosuppressive activity. In human disease, three major MDSC subpopulations can be defined as monocytic (M-MDSC), granulocytic [polymorphonuclear-MDSC (PMN-MDSC)], and early stage (e-MDSC), which lacks myeloid lineage markers of the former two subsets. The purpose of this study was to determine and compare the immunosuppressive capacity and clinical relevance of each of these subsets in patients with solid cancer.
Experimental Design: The frequency of MDSC subsets in the peripheral blood was determined by flow cytometry in a cohort of 49 patients with advanced head and neck cancer (HNC) and 22 patients with urological cancers. Sorted and purified MDSC subsets were tested in vitro for their T-cell–suppressive capacity. Frequency of circulating MDSC was correlated with overall survival of patients with HNC.
Results: A high frequency of PMN-MDSC most strongly correlated with poor overall survival in HNC. T-cell–suppressive activity was higher in PMN-MDSC compared with M-MDSC and e-MDSC. A subset of CD66b+/CD11b+/CD16+ mature PMN-MDSC displayed high expression and activity of arginase I, and was superior to the other subsets in suppressing proliferation and cytokine production of T cells in both cancer types. High levels of this CD11b+/CD16+ PMN-MDSC, but not other PMN-MDSC subsets, strongly correlated with adverse outcome in HNC.
Conclusions: A subset of mature CD11b+/CD16+ PMN-MDSC was identified as the MDSC subset with the strongest immunosuppressive activity and the highest clinical relevance. Clin Cancer Res; 24(19); 4834–44. ©2018 AACR.
Septic Pulmonary Emboli From Peripheral Suppurative Thrombophlebitis: A Case Report and Literature Review
Authors: Ho Vy T. , Rothenberg Kara A. , McFarland Graeme , Tran Kenneth , Aalami Oliver O. 
Published: June 2018

Background: We report the case of a 90-year old woman who presented with septic pulmonary emboli due to suppurative thrombophlebitis at an old peripheral intravenous site. Methods: After unsuccessful treatment with antibiotics, the patient was taken to the operating room for excision and drainage of the purulent superficial vein. Results: We review the literature and discuss the presentation, risk factors, treatment options, and complications of this often-overlooked disease entity. Conclusions: Suppurative thrombophlebitis is a rare but morbid disease that requires a high level of clinical suspicion to diagnose.
Novel lumen‐apposing metal stent for the drainage of pancreatic fluid collections: An Italian multicentre experience
Authors: Petrone Maria Chiara , Archibugi Livia , Forti Edoardo , Conigliaro Rita , Di Mitri Roberto , Tarantino Ilaria , Fabbri Carlo , Larghi Alberto , Testoni Sabrina Gloria Giulia , Mutignani Massimiliano , Arcidiacono Paolo Giorgio 
Published: June 2018

BackgroundEndoscopic ultrasound (EUS)‐guided drainage is the procedure of choice for pancreatic fluid collection (PFC) management. Recently developed lumen‐apposing fully covered self‐expandable metal stents (LAMSs) may facilitate drainage, especially of necrotic and complex PFCs.ObjectiveTo evaluate the feasibility and efficacy of a newly developed LAMS (Nagi, Taiwong Medical Co. Ltd, South Korea) in the drainage of PFCs.MethodsRetrospective analysis of LAMS drainage of PFCs from seven centres. Patient demographic, EUS and radiological findings, PFCs aetiology, procedural technical and clinical success, and adverse events were evaluated.ResultsSixty‐seven patients with mean age 58.8 ± 14 years (68.7% males) were included in the analysis. Of these, 44 patients had pseudocyst (PP) and 23 patients had walled‐off pancreatic necrosis (WOPN). Technical success was achieved in 98.5% of cases and clinical success in 94%. The adverse event rate was 24.2%, higher and mostly due to stent migration and occlusion in the WOPN group as compared to the PP group, despite the time to stent removal being significantly lower in the WOPN group.ConclusionsPFC drainage using the Nagi stent is highly feasible and effective, with a relatively safe profile. Future studies enrolling more patients with complex PFCs are needed to clearly establish the role of this stent in PFC management.
FORMAÇÃO DOCENTE NA PÓS-GRADUAÇÃO EM ADMINISTRAÇÃO: UMA ANÁLISE QUALITATIVA EM DUAS UNIVERSIDADES FEDERAIS
Authors: Narciso Eliza Rezende Pinto , Lourenço Cléria 
Published: June 2018

A formação pedagógica para a docência no ensino superior é frequentemente tratada como papel dos programas de pós-graduação stricto sensoe também como fator constantemente negligenciado por esses cursos em detrimento da atividade de pesquisa. Diante desse cenário, este trabalho teve como objetivo compreender como se dá o processo de formação para a docência no ensino superior nos programas de pós-graduação em administração. Por meio da pesquisa qualitativa, foram realizados grupos focais em duas universidades federais que possuem em seu escopo Programas de Pós-graduação em administração que oferecem, simultaneamente, cursos de Mestrado e Doutorado em administração, consolidados e reconhecidos pela CAPES. Participaram da pesquisa 27 pós-graduandos. A técnica de análise dos dados foi a análise de conteúdo. Como parte dos resultados, pode-se concluir que, os programas de pós-graduação em administração estudados são ambientes precários no que diz respeito à formação para a docência e que os processos de formação não contemplam a formação pedagógica, tornando a experiência com a docência, uma experiência precária.
Long-term Outcomes of Lifestyle Intervention to Prevent Diabetes in American Indian and Alaska Native Communities: The Special Diabetes Program for Indians Diabetes Prevention Program
Authors: Jiang Luohua , Johnson Ann , Pratte Katherine , Beals Janette , Bullock Ann , Manson Spero M. ,   the Special Diabetes Program for Indians Diabetes Prevention Program
Published: June 2018

OBJECTIVE
Evidence for long-term translational effectiveness of lifestyle interventions in minority populations is scarce. This article reports long-term outcomes, for up to 10 years, of such an intervention to prevent diabetes in American Indian and Alaska Native (AI/AN) communities.

RESEARCH DESIGN AND METHODS
From January 2006 to July 2016, the Special Diabetes Program for Indians Diabetes Prevention Program implemented the Diabetes Prevention Program lifestyle intervention among 46 AI/AN health care programs. Enrolled participants underwent a thorough clinical assessment at baseline, after completing the Lifestyle Balance Curriculum (postcurriculum assessment), and annually thereafter. Proportional hazards regression was used to estimate the association between diabetes incidence and postcurriculum weight loss status.

RESULTS
Of 8,652 enrolled participants, 65% finished the postcurriculum assessment. The assessment completion rate diminished over time to 13% in year 10. Among those with postcurriculum weight measurements, 2,028 (36%) lost &gt;5% of their initial weight, 978 (17%) lost 3–5%, whereas 2,604 (47%) had &lt;3% weight loss (average weight loss 3.8%). Compared with those with &lt;3% weight loss, participants with &gt;5% weight loss had a 64% (95% CI 54–72) lower risk of developing diabetes during the first 6 years of follow-up, whereas those with 3–5% weight loss had 40% (95% CI 24–53) lower risk.

CONCLUSIONS
Moderate to small weight loss was associated with substantially reduced long-term risk of diabetes in diverse AI/AN communities. High participant attrition rates and nonoptimal postcurriculum weight loss are important challenges found in this translational effort implemented in an underserved population.
Clinical evaluation of a benchtop dry chemistry analyzer for measurement of ammonium concentrations in canine plasma samples
Authors: Funes Silvia , Gordon Jana , Gorman Elena , Ruaux Craig 
Published: June 2018

Abstract
OBJECTIVE To evaluate the clinical performance of a veterinary benchtop dry chemistry analyzer for measurement of plasma ammonium concentrations in dogs by comparing results with those obtained by a reference standard test method.
DESIGN Prospective evaluation study.
SAMPLE 32 blood samples from 30 dogs (16 with and 14 without suspected hepatobiliary disease).
PROCEDURES Blood samples were collected by jugular venipuncture. A veterinary benchtop dry chemistry analyzer and a reference standard (enzymatic) test method were used to measure ammonium concentrations in plasma collected from heparinized whole blood. Bland-Altman plots were used to assess intermethod agreement. Results were compared by linear regression, and correlation was calculated by the Pearson method. Samples were classified as having high or normal ammonium concentrations on the basis of cutoff data for the relevant test method; results were compared between methods to evaluate diagnostic agreement.
RESULTS 31 of 32 (97%) samples were classified correctly with the benchtop analyzer; 1 sample with a high ammonium concentration was classified as having a normal value (ie, false-negative result) by this method. A strong positive correlation (r2 = 0.989) was found between methods, with constant, proportional, negative bias for benchtop analyzer results. The interassay coefficient of variation (ie, precision) for measurement of an internal standard with the benchtop analyzer was 2.74% (n = 20 repetitions).
CONCLUSIONS AND CLINICAL RELEVANCE The dry chemistry analyzer used in the study had acceptable clinical performance for detection of high versus normal ammonium concentrations in canine plasma, indicating the method can be used to aid diagnosis in dogs with suspected hepatobiliary disease.
РОБЕРТ МИННУЛЛИН ИҖАТЫ: БАЛАЛАР ӨЧЕН ТӘРҖЕМӘЛӘРДӘ ИҖАДИ ИҖАТ КУӘСЕНЕҢ ЧАГЫЛЫШЫ
Authors: MİNGAZOVA Liailia 
Published: June 2018

Хезмәтнең тикшеренү обекты булып, ТР халык шагыйре, ТР Г.Тукай исемендәге
Дәүләт премиясе лауреаты, Г.-Х.Андерсен
исемендәге Почетлы диплом иясе Роберт Миңнуллинның
тәрҗемәләре тора. Рус,
каракалпак, төрекмән, мари, чуаш, грузин, әрмән, казакъ, удмурт, литва кебек
милләт шагыйрьләренең әсәрләре аның тәрҗемәсендә татар укучысына да якын.

Мәгълүм ки, гасырлар дәвамында милли идеаллар, әхлакь
принцилары аша милли әдәбиятлар формалаша. Төрле тарихи этапларда, географик
шартлар белән дә бәйле, миллилек, гореф-гадәтләр, традицияләр кебек төшенчәләр
ярдәмендә балалар күңеленә тәэсир итәрдәй нигезле психологик алымнар, чаралар
туа һәм алар яшь буында милли үзаң формалашуда нигез булып тора. Р. Миңнуллинның уңышлы тәрҗемәләре аша
балачак иле, сабыйларның дөньяны танып белүе, төрле милләт балаларының уйлары
һәм теләкләре бердәй дәрәҗәдә охшаш һәм тәңгәл икәнлеге отышлы ачыла. Ягъни, Р. Миңнуллин тәрҗемә эшчәнлегендә телнең бөтен эчке мөмкинлекләреннән дә
файдаланып эш итә.
A Descriptive Case Study of Using Line Application for Learning Writing
Authors: Ratnaningsih Paskalina Widiastuti 
Published: June 2018

Abstract

Writing as part of English skills is highly concerned in the present days. The development of technology influences the use of media for teaching-learning activities. This paper aims at discovering students’ learning in English writing by using Line application as the media for learning. As one of the applications in the smartphone, Line application can be used in the teaching-learning activities. A task-based instruction is applied in the study. The method of study is case-study. The data were gathered with observation, interview, and document review. Holistic analysis was conducted after getting the data. The research result is writtten in descriptive. The description is divided into major themes. The themes are mainly in the scope of the use of technology for writing.

Keywords: case study, line application, writing, task-based instruction
The Influence of Shiritory Game toward Improvement the Students’ Vocabulary at MTS DDI Ujung Lare Parepare
Authors: Nanning Nanning , Nurasiza Nurasiza , Ibrahim Abd. Rauf 
Published: June 2018

This research is based on two major points namely fulfilling the students’ need regards English vocabulary ability and on how to attract the students to be active in learning process by using media. The objectives of the research are to find out whether or not the use of shiritory game can improve the vocabulary mastery of the eight year students of MTs DDI Ujung Lare Parepare and to know the use of Shiritory Game as learning media in improving the activeness of the eight year students of MTs DDI Ujung Lare Parepare in English learning process. Besides, this research is expected can be useful reference for those who want to use media in their teaching and learning process. In this research the researcher applied class experimental design, with two classes, experiment and control class. In one class consist of four meetings. The samples of the research were 20 students from Class VIII MTs DDI Ujung Lare Parepare. After analyzing the research data, this research revealed the mean score of the students before giving treatment which reached 7.55. After giving treatment, their vocabulary mastery has increase, this was proved with the mean score 15.45. The data after pretest and posttest between experiment and control group showed that the using of Shiritory game has been influenced the students’ achievement with significance Sig Value=0.020<0.05. Comparing with conventional games, Shiritori game is better in improving students’ achievement in learning vocabulary because Shiritori game may increase students’ concentration in playing it, also increase students in memorizing and spelling more new vocabularies and also make them enjoyable, fun and competitive in doing this games. It means that the using of Shiritory games has a good influence in students’ learning since it helping students to develop their English language abilities.
Impact of Multi-Causal Transport Mechanisms in an Electrolyte Supported Planar SOFC with (ZrO2)x−1(Y2O3)x Electrolyte
Authors: Valadez Huerta Gerardo , Flasbart Vincent , Marquardt Tobias , Radici Pablo , Kabelac Stephan 
Published: June 2018

The calculation of the entropy production rate within an operational high temperature solid oxide fuel cell (SOFC) is necessary to design and improve heating and cooling strategies. However, due to a lack of information, most of the studies are limited to empirical relations, which are not in line with the more general approach given by non-equilibrium thermodynamics (NET). The SOFC 1D-model presented in this study is based on non-equilibrium thermodynamics and we parameterize it with experimental data and data from molecular dynamics (MD). The validation of the model shows that it can effectively describe the behavior of a SOFC at 1300 K. Moreover, we show that the highest entropy production is present in the electrolyte and the catalyst layers, and that the Peltier heat transfer is considerable for the calculation of the heat flux in the electrolyte and cannot be neglected. To our knowledge, this is the first validated model of a SOFC based on non-equilibrium thermodynamics and this study can be extended to analyze SOFCs with other solid oxide electrolytes, with perovskites electrolytes or even other electrochemical systems like solid oxide electrolysis cells (SOECs).
X-trails: Notes on Another English School
Authors: Jöttkandt Sigi 
Published: June 2018

Abstract
This article responds to J. Hillis Miller and Ranjan Ghosh's Thinking Literature across Continents by examining the recurrence of a certain figure of illumination in their readings of Matthew Arnold's “The Scholar-Gipsy” and Wallace Stevens's “The Motive for Metaphor.” In this reading, light, as central metaphor for poetic insight and learning, devolves into an x-factor, which is traced back through Joseph Glanvill to Edgar Allan Poe. As a figure for Miller's and Ghosh's own deconstructive reading practices, this x puts into question the core assumptions of literary pedagogy, and especially their book's claim to be a dialogue across continents.
Pondering Along with Ranjan Ghosh and J. Hillis Miller's Thinking Literature across Continents
Authors: Roraback Erik S. 
Published: June 2018

Abstract
This context review/response article builds on and extends the insights afforded by Ranjan Ghosh and J. Hillis Miller's rich field of terrain they till in their coauthored Thinking Literature across Continents (2016). This article finds creative inspiration in their insights that merit a careful look and assessment in order to consider our conditions of possibility for a rejuvenated culture of learning and of the book in a hyper-mediatized and digitized twenty first century. I argue that Ghosh and Miller's dynamic calls for interdisciplinarity, and for a larger sense of the genuinely critical and creative, would work well in tandem with a broader sense of what constitutes literature, and of how we can deploy these cultural forms for forms of readerly and cultural literacy that would enable cultural and economic democracy to thrive. I argue that as a form of universality, literature merits this sort of caretaking and cultivation for our shared and collective possible futures and forms of critical citizenship.
Steinbeck Today
Authors: Ray William 
Published: June 2018

Abstract
In the second half of 2017, four works by John Steinbeck dominated references to his life and writing by journalists, productions of his works by theatrical artists, and events in Europe and the United States. His writing and life were examined for evidence of influence and intention by lawyers and scholars, and political conditions in America continued to increase commentary and reflections on his writing about the United States, particularly Travels with Charley.
Comparative Abundance, Species Composition, and Demographics of Continental Shelf Fish Assemblages throughout the Gulf of Mexico
Authors: Murawski Steven A. , Peebles Ernst B. , Gracia Adolfo , Tunnell John W. , Armenteros Maickel 
Published: June 2018

Abstract
We analyzed the results of the first comprehensive, systematic, fishery independent survey of Gulf of Mexico (GoM) continental shelves using data collected from demersal longline sampling off the United States, Mexico, and Cuba. In total, 166 species were sampled from 343 longline sets during 2011–2017, which deployed 153,146 baited hooks, catching 14,938 fish. Abundance, species richness, and Shannon–Wiener diversity indices by station were highest in mid shelf depths (~100 m), declining by about half in deeper waters. Six spatial assemblages were identified by testing the results of cluster analysis using similarity profile analysis and then plotting the geographic location of identified station clusters. A high degree of depth related and horizontal zonation was evident for demersal fish species. Multispecies CPUE (number per 1,000 hook hours) was highest off the north central (NC) and northwestern (NW) GoM and lower on the West Florida Shelf (WFS), Cuba (CUB), Yucatan Peninsula (YP), and southwestern (SW) GoM. Snappers and groupers were most abundant in the WFS and CUB, while elasmobranchs were the dominant taxa in the NC and NW GoM. Pelagic species were relatively rare everywhere (owing to the use of demersal longline gear), but were most dense off CUB. Species richness was highest in the NC and WFS subareas and lowest in the NW and CUB. Slopes of multispecies size spectra, which integrated mortality, recruitment, growth, and species interactions among size groups, were shallowest in the NW and NC GoM and steepest off the WFS and YP. These results provide a basis for evaluating the relative resiliency potential of species assemblages across the continental shelves of the GoM, and thus for identifying subareas that are most vulnerable to acute and chronic perturbations from cumulative effects of fishing, climate change, pollution (including oil spills), habitat loss, and invasive species.