bluuebunny/crossref_metadata_2025_split huggingface dataset:
High‐Performance Self‐Powered PEC Photodetectors Based on 2D BiVO4/MXene Schottky Junction
Authors: Zhou Siqin , Jiang Chenxiao , Han Jinlu , Mu Yanqi , Gong Jian Ru , Zhang Juan 
Published: November 2024

AbstractAs an emerging field, self‐powered photoelectrochemical (PEC) photodetectors have gradually attracted extensive attention thanks to the unique working characteristics of low preparation cost, strong tunability of device performance, and environmental friendliness. However, short absorption wavelength range, low efficiency of visible light utilization, and low responsivity remain challenges for performance improvements. Here, the PEC photodetectors based on the 2D BiVO4/MXene Schottky junction structure, which shows excellent performance with high photocurrent density (≈3.90 mA cm−2 at 0 VSCE under AM 1.5 G, 150 mW cm−2), good responsivity (790.2 mA W−1 under 447 nm), fast response time (tr/tf = 8/14 ms), and long‐term stability (keep 17 000 s and 22 000 cycles) are fabricated. These can be attributed to the built‐in electric field at the BiVO4/MXene Schottky junction interface, which accelerates the transfer of photogenerated electrons and holes, and inhibits interfacial charge recombination. Additionally, the MXene nanosheets improve the absorption of visible‐light‐induced photons on the valence band of BiVO4. These excellent properties show that this work provides a scientific experimental reference for the further development of PEC photodetectors.
Engineering the Functional Expansion of Microneedles
Authors: Yang Shengfei , Xu Yihua , Zhu Mingjian , Yu Yawei , Hu Weitong , Zhang Tianyuan , Gao Jianqing 
Published: November 2024

AbstractMicroneedles (MNs), composed of an array of micro‐sized needles and a supporting base, have transcended their initial use to replace hypodermic needles in drug delivery and fluid collection, advancing toward multifunctional platforms. In this review, four major areas are summarized in interdisciplinary engineering approaches combined with MNs technology. First, electronics engineering, the most extensively researched field, enables applications in biomonitoring, electrical stimulation, and closed‐loop theranostics through the generation, transmission, and transformation of electrical signals. Second, in electromagnetic engineering, the responsiveness of electromagnetic induction offers prospects for remote and programmable therapeutic applications. Third, photonic engineering endows MNs with novel functionalities, such as waveguiding and photonic manipulation to enhance optical therapeutic capabilities and facilitate the visualization of disease progression and treatment processes. Lastly, it reviewed the role of mechanical engineering in conferring shape adaptability and programmable motion features necessary for various MNs applications. This review focuses on the functionalities that emerge from the intersection of MNs with complementary engineering technologies, aiming to inspire further research and innovation in microneedle technology for biomedical applications.
Twisted Metasurfaces for On‐Demand Focusing Localization
Authors: He Guangming , Qian Chao , Jia Yuetian , Fan Zhixiang , Wang Huaping , Chen Hongsheng 
Published: November 2024

AbstractDynamic focusing of electromagnetic (EM) waves is a cornerstone in various applications, encompassing aerospace communication, sensing, and high‐resolution imaging. Recently, the advent of intelligent metasurfaces, hailed as the next evolutionary step, has revolutionized self‐adaptive functionalities. However, their extensive embeddings of active components pose a great challenge associated with escalated costs, heightened power consumption, and increased complexity, thus hindering large‐scale implementation. Here, a cost‐effective approach for dynamic EM focusing utilizing a twisted metasurface is introduced, which integrates a transmissive layer with a reflective layer in a cascade fashion. This innovative design leverages the mutual rotation between two layers to enable the precise manipulation of beam propagation and scanning area, allowing for the flexible localization of the focal point across a wide range, spanning −44.17° to 44.17° in elevation and 0° to 360° in azimuth. This capability is underpinned by the strategic fusion of multiple phase profiles, including gradient and Gaussian phase. In the experiment, a goal‐oriented system is built up whose outcomes demonstrate a striking alignment with the simulated results, achieving a correlation coefficient of 96.7%. This work presents a streamlined pathway toward dynamic EM focusing and the related applications constrained by space and power limitations.
Selective 1,2‐Carboimination of Isothiocyanates to Access S‐Substituted Isothioureas via Energy Transfer Catalysis
Authors: Chen Li‐Ning , Liang Shu‐Nuo , Luo Juan , Chen Dan‐Na , Ye Zhi‐Peng , Xia Peng‐Ju 
Published: November 2024

AbstractHerein, we introduce a novel method for the synthesis of S‐substituted isothiourea compounds via the selective 1,2‐carboimination between oxime esters as bifunctional reagents and the C=S bond of isothiocyanates under visible‐light catalysis. This approach deviates from conventional methods by precisely modulating the substrate electronics to selectively functionalize the C=S bond of isothiocyanates over the C=N bond, eliminating the need for strong bases and high temperatures and bypassing the formation of thiourea intermediates. Consequently, this protocol enables the efficient one‐step synthesis of S‐alkyl isothioureas, with featuring mild reaction conditions, operational simplicity and broad substrate scope.
An EED/PRC2‐H19 Loop Regulates Cerebellar Development
Authors: Liu Pei‐Pei , Han Xiao , Li Xiao , Dai Shang‐Kun , Xu Ya‐Jie , Jiao Lin‐Fei , Du Hong‐Zhen , Zhao Li‐Hua , Li Rong‐Feng , Teng Zhao‐Qian , Yang Yun‐Gui , Liu Chang‐Mei 
Published: November 2024

AbstractEED (embryonic ectoderm development) is a core subunit of the polycomb repressive complex 2 (PRC2), which senses the trimethylation of histone H3 lysine 27 (H3K27). However, its biological function in cerebellar development remains unknown. Here, we show that EED deletion from neural stem cells (NSCs) or cerebellar granule cell progenitors (GCPs) leads to reduced GCPs proliferation, cell death, cerebellar hypoplasia, and motor deficits in mice. Joint profiling of transcripts and ChIP‐seq analysis in cerebellar granule cells reveals that EED regulates bunches of genes involved in cerebellar development. EED ablation exhibits overactivation of a developmental repressor long non‐coding RNA H19. Importantly, an obvious H3K27ac enrichment is found at Ctcf, a trans‐activator of H19, and H3K27me3 enrichment at the H19 imprinting control region (ICR), suggesting that EED regulates H19 in an H3K27me3‐dependent manner. Intriguingly, H19 deletion reduces EED expression and the reprogramming of EED‐mediated H3K27me3 profiles, resulting in increased proliferation, differentiation, and decreased apoptosis of GCPs. Finally, molecular and genetic evidence provides that increased H19 expression is responsible for cerebellar hypoplasia and motor defects in EED mutant mice. Thus, this study demonstrates that EED, H19 forms a negative feedback loop, which plays a crucial role in cerebellar morphogenesis and controls cerebellar development.
Hyperglycemia‐Enhanced Neutrophil Extracellular Traps Drive Mucosal Immunopathology at the Oral Barrier
Authors: Wang Qian , Lin Weimin , Lei Kexin , Wang Hui , Zhang Xiaohan , Jiang Shuang , Zhang Danting , Wang Wen , Cao Shuqin , Li Yuyu , Yu Bo , Wang Yuan , Yin Qi , Yuan Quan 
Published: November 2024

AbstractType 2 diabetes (T2D) is a risk factor for mucosal homeostasis and enhances the susceptibility to inflammation, in which neutrophils have been increasingly appreciated for their role. Here, barrier disruption and inflammation are observed at oral mucosa (gingiva) of T2D patients and mice. It is demonstrated that neutrophils infiltrate the gingival mucosa of T2D mice and expel obvious neutrophil extracellular traps (NETs), while removal of NETs alleviates the disruption of mucosal barrier. Mechanistically, gingival neutrophils released NETs are dependent of their metabolic reprogramming. Under hyperglycemic condition, neutrophils elevate both glucose incorporation and glycolysis via increased expression of GLUT1. Moreover, significantly increased levels of NETs are observed in local gingival lesions of patients, which are associated with clinical disease severity. This work elucidates a causative link between hyperglycemia and oral mucosal immunopathology, mediated by the altered immuno‐metabolic axis in neutrophil, thereby suggesting a potential therapeutic strategy.
CITMIC: Comprehensive Estimation of Cell Infiltration in Tumor Microenvironment based on Individualized Intercellular Crosstalk
Authors: Zhao Xilong , Wu Jiashuo , Lai Jiyin , Pan Bingyue , Ji Miao , Li Xiangmei , He Yalan , Han Junwei 
Published: November 2024

AbstractThe tumor microenvironment (TME) cells interact with each other and play a pivotal role in tumor progression and treatment response. A comprehensive characterization of cell and intercellular crosstalk in the TME is essential for understanding tumor biology and developing effective therapies. However, current cell infiltration analysis methods only partially describe the TME's cellular landscape and overlook cell‐cell crosstalk. Here, this approach, CITMIC, can infer the cell infiltration of TME by simultaneously measuring 86 different cell types, constructing an individualized cell‐cell crosstalk network based on functional similarities between cells, and using only gene transcription data. This is a novel approach to estimating the relative cell infiltration levels, which are shown to be superior to the current methods. The TME cell‐based features generated by analyzing melanoma data are effective in predicting prognosis and treatment response. Interestingly, these features are found to be particularly effective in assessing the prognosis of high‐stage patients, and this method is applied to multiple high‐stage adenocarcinomas, where more significant prognostic performance is also observed. In conclusion, CITMIC offers a more comprehensive description of TME cell composition by considering cell‐cell crosstalk, providing an important reference for the discovery of predictive biomarkers and the development of new therapeutic strategies.
Whisker‐Implanted Biomimetic Electronic Skin for Tactile Sensing and Blind Perception
Authors: Zarei Mohammad , Jeong An Woo , Lee Seung Goo 
Published: November 2024

AbstractRodent whiskers are a distinct class of tactile sensors that work in conjunction with the biological skin to discern airstreams and obstacles with remarkable sensitivity, facilitating navigation around proximate objects. In this study, a flexible artificial skin is developed comprising sensory active units, including electronic skin (e‐skin) and an artificial whisker, inspired by the sensory capabilities of rodent skin and whiskers. As a novel strategy, unique congruent air pockets are introduced within the e‐skin to enhance the sensitivity. Mechanical stimuli applied to the artificial whisker are efficiently transmitted to the active e‐skin, which generates a sensitive tactile perception response. The developed artificial skin exhibits high sensitivity, a wide sensing range, high flexibility, superior stability, and tensile strength. The artificial whisker facilitates the sensitive detection of a broad range of applied mechanical forces. Therefore, the artificial skin can sense subtle and vigorous tactile stimuli including airstreams and field obstacles. The ability to sense, discriminate, and decipher the airstreams and obstacles imparts outstanding tactile sensing and blind perception characteristics to the artificial skin. This artificial skin is a promising platform for the development of sensitive e‐skins suitable for a broad range of applications, such as human‐machine interfaces, robotics, and wearable electronics.
Capillary Skimming of Floating Microplastics via a Water‐Bridged Ratchet
Authors: Cho Seohyun , Park Sang Jin , Lee Young Jin , Lee You Jun , Lee Young A , Kim Ho‐Young , Kim Seong Jin , Chung Seok , Moon Myoung‐Woon 
Published: November 2024

AbstractFloating microplastics (MPs) have recently become a major concern in marine pollution; however, current filter‐based technology is hardly effective for directly removing such MPs from the water surface because of specific mesh size and clogging issues. This paper introduces a new skimming concept for removing floating MPs utilizing capillary force mediated by the elevation of a hydrophilic ratchet at the air−water interface. MPs floating near the ratchet surface are spontaneously forced toward the ratchet with a concave water meniscus, driven by the Cheerios effect. The MPs can then be skimmed and temporarily held by the deforming concave water meniscus as the ratchet rises. Here, it is found that the stability of the water bridge plays a crucial role in skimming success because it provides capillary adhesion between the MP and the ratchet. The proposed capillary skimming method is observed to be effective across nearly all types of floating MPs, ranging in size from 1 to 4 mm, and with densities varying from 0.02 to 0.97 g cm−3, which is also demonstrated by a prototype of marine robot cleaner.
Injectable Genetic Engineering Hydrogel for Promoting Spatial Tolerance of Transplanted Kidney in Situ
Authors: Lin Jinwen , Liu Shuaihui , Xue Xing , Lv Junhao , Zhao Lingfei , Yu Liqin , Wang Huiping , Chen Jianghua 
Published: November 2024

AbstractThe establishment of a tolerant space to realize the co‐stimulation of cytokines and contact‐dependent molecules remain challenging in allotransplant. Here, an injectable genetically engineered hydrogel (iGE‐Gel) is reported, which developed with a multivalent network of FOXP3 engineered extracellular vesicles (Foe‐EVs) through the hydrophobic interaction between stearic acid modified hyaluronic acid (HASA) and the membrane phospholipids of extracellular vesicles (EVs). The iGE‐Gel exhibited self‐healing properties, injectability and biocompatibility. It is revealed that iGE‐Gel displayed with abundant regulatory cytokines and coinhibitory contact molecules, promoting the formation of immune tolerance in situ. The multiplex immunohistofluorescence confirmed tolerant niches is dominated by FOXP3+ Tregs and PDL1+ cells in the allograft, which reduced the drainage of alloantigens to subcapsular sinus of lymph nodes, and suppressed the formation of germinal centers. Remarkably, the proportion of alloreactive T cells (IFN‐γ/IL‐2) and B cells (IgG1/IgG2a/IgG3) as well as the serum titers of donor specific antibody (DSA) is decreased by iGE‐Gel. In murine allogeneic transplantation, the injection of iGE‐Gel significantly alleviated immune cell infiltration and complement damage in the graft, preserved the structure and function of renal cells and prolonged recipient survival period from 30.8 to 79.3 days, highlighting the potential of iGE‐Gel as a transformative treatment in allotransplant.
Tailoring Atomic Ordering Uniformity Enables Selectively Leached Nanoporous Pd‐Ni‐P Metallic Glass for Enhanced Glucose Sensing
Authors: Lou Yu , Li Jian , Yao Zhongzheng , Wu Zhenduo , Ying Huiqiang , Tan Lan , Liu Sinan , Zeng Jianrong , Yu Ruohan , Liu Hong , Wang Xun‐Li , Zhu He , Lan Si 
Published: November 2024

AbstractConstructing nanostructures, such as nanopores, within metallic glasses (MGs) holds great promise for further unlocking their electrochemical capabilities. However, the MGs typically exhibit intrinsic atomic‐scale isotropy, posing a significant challenge in directly fabricating anisotropic nanostructures using conventional chemical synthesis. Herein a selective leaching approach, which focuses on tailoring the uniformity of atomic ordering, is introduced to achieve pore‐engineered Pd‐Ni‐P MG. This innovative approach significantly boosts the number of exposed active sites, thereby enhancing the electrochemical sensitivity for glucose detection. Electrochemical tests reveal that the nanoporous Pd‐Ni‐P MG exhibits high sensitivity (3.19 mA mm⁻¹ cm⁻2) and remarkable stability (97.7% current retention after 1000 cycles). During electrochemical cycling, synchrotron X‐ray pair distribution function and X‐ray absorption fine structure analyses reveal that the distance between active sites decreases, enhancing electron transport efficiency, while the medium‐range ordered structure of the Pd‐Ni‐P MG remains stable, contributing to its exceptional glucose sensing capabilities. A microglucose sensor is successfully developed by integrating the nanoporous Pd‐Ni‐P MG with a screen‐printed electrode, demonstrating the practical applicability. This study not only offers a new avenue for the design of highly active nanoporous MGs but also sheds light on the mechanisms behind the high electrochemistry performance of MGs.
Sirtuin1 Suppresses Calcium Oxalate Nephropathy via Inhibition of Renal Proximal Tubular Cell Ferroptosis Through PGC‐1α‐mediated Transcriptional Coactivation
Authors: Duan Chen , Li Bo , Liu Haoran , Zhang Yangjun , Yao Xiangyang , Liu Kai , Wu Xiaoliang , Mao Xiongmin , Wu Huahui , Xu Zhenzhen , Zhong Yahua , Hu Zhiquan , Gong Yan , Xu Hua 
Published: November 2024

AbstractCalcium oxalate (CaOx) crystals induce renal tubular epithelial cell injury and subsequent nephropathy. However, the underlying mechanisms remain unclear. In the present study, single‐cell transcriptome sequencing is performed on kidney samples from mice with CaOx nephrocalcinosis. Renal proximal tubular cells are identified as the most severely damaged cell population and are accompanied by elevated ferroptosis. Further studies demonstrated that sirtuin1 (Sirt1) effectively reduced ferroptosis and CaOx crystal‐induced kidney injury in a glutathione peroxidase 4 (GPX4)‐dependent manner. Mechanistically, Sirt1 relies on peroxisome proliferator‐activated receptor gamma coactivator 1α (PGC‐1α) to promote resistance to ferroptosis in the tubular epithelium, and PGC‐1α can recruit nuclear factor erythroid 2‐related factor 2 (NRF2) to the promoter region of GPX4 and co‐activate GPX4 transcription. This work provides new insight into the mechanism of CaOx crystal‐induced kidney injury and identifies Sirt1 and PGC‐1α as potential preventative and therapeutic targets for crystal nephropathies.
DNA Sensor ABCF1 Phase Separates With cccDNA to Inhibit Hepatitis B Virus Replication
Authors: Ren Caiyue , Zhang Zhaoying , Dou Yutong , Sun Yang , Fu Zhendong , Wang Liyuan , Wang Kai , Gao Chengjiang , Fan Yuchen , Sun Shuguo , Yue Xuetian , Li Chunyang , Gao Lifen , Liang Xiaohong , Ma Chunhong , Wu Zhuanchang 
Published: November 2024

AbstractHepatitis B virus (HBV) covalently closed circular DNA (cccDNA) contributes to viral persistence and recurrence, however, how the host innate immune system responds to cccDNA is still less known. Here, based on cccDNA‐hepatic proteins interaction profiling, DNA sensor ATP‐binding cassette subfamily F member 1 (ABCF1) is identified as a novel cccDNA‐binding protein and host restriction factor for HBV replication. Mechanistically, ABCF1 recognizes cccDNA by KKx4 motif and forms phase‐separated condensates by the poly‐glutamine (PolyQ) region of the N‐terminal intrinsically disordered low‐complexity domain (LCD). Subsequently, ABCF1‐cccDNA phase separation not only activates the type I/III interferon (IFN‐I/III) pathway but also prevents Pol II accumulation on cccDNA to inhibit HBV transcription. In turn, to sustain viral replication, HBV reduces ABCF1 expression by HBx‐mediated ubiquitination and degradation of SRY‐box transcription factor 4（SOX4）, leading to defects in SOX4‐mediated upregulation of ABCF1 transcription. Taken together, the study shows that ABCF1 interacts with cccDNA to form phase separation that dually drives innate immune signaling and HBV transcriptional inhibition. These findings shed new light on the understanding of host defense against cccDNA and provide a novel promising therapeutic strategy for HBV infection.
Efficient Predictor for Immunotherapy Efficacy: Detecting Pan‐Clones Effector Tumor Antigen‐Specific T Cells in Blood by Nanoparticles Loading Whole Tumor Antigens
Authors: Zeng Weibiao , Wang Jin , Chen Zhike , Yang Jian , Zhu Ao , Zheng Yan , Chen Xianlan , Liu Yuhan , Wu Leilei , Xie Yufeng , Ju Sheng , Chen Jun , Ding Cheng , Li Chang , Tong Xin , Liu Mi , Zhao Jun 
Published: November 2024

AbstractCancer involves tumor cells and tumor‐specific immunity. The ability to accurately quantify tumor‐specific immunity is limited. Most immunotherapies function by activating new effector tumor antigen‐specific T cells (ETASTs) or reactivating the pre‐existing ETASTs repertoire. Therefore, the amount of ETASTs can be used to characterize immunotherapy efficacy. Tumor antigens are highly heterogeneous and detecting most ETASTs is challenging. Therefore, nanoparticles loading whole‐cell tumor antigens are used to activate and detect pan‐clones ETASTs in the blood. The differences between ETASTs and other T cells are transformed into activated and non‐activated states. By measuring markers of the activated status and cytotoxic function of ETASTs, it can distinguish ETASTs from other T cells. ETASTs in patients with lung cancer are higher than those in healthy individuals and those with benign pulmonary nodules. Therapeutic efficacy positively correlated with the number of ETASTs in the blood. ETATS levels increase only in the blood of patients who respond to immunotherapy. Single‐cell sequencing studies validated these findings. This study provides a highly accurate, specific, non‐invasive, and efficient biomarker for predicting immunotherapy efficacy in lung and other cancers. This method can also be applied to evaluate the efficacy of other treatments, such as radiotherapy, oncolytic viruses, and nanomedicine‐based therapies.
Network Medicine‐Based Strategy Identifies Maprotiline as a Repurposable Drug by Inhibiting PD‐L1 Expression via Targeting SPOP in Cancer
Authors: Tian Saisai , Xu Mengting , Geng Xiangxin , Fang Jiansong , Xu Hanchen , Xue Xinying , Hu Hongmei , Zhang Qing , Yu Dianping , Guo Mengmeng , Zhang Hongwei , Lu Jinyuan , Guo Chengyang , Wang Qun , Liu Sanhong , Zhang Weidong 
Published: November 2024

AbstractImmune checkpoint inhibitors (ICIs) are drugs that inhibit immune checkpoint (ICP) molecules to restore the antitumor activity of immune cells and eliminate tumor cells. Due to the limitations and certain side effects of current ICIs, such as programmed death protein‐1, programmed cell death‐ligand 1, and cytotoxic T lymphocyte‐associated antigen 4 (CTLA4) antibodies, there is an urgent need to find new drugs with ICP inhibitory effects. In this study, a network‐based computational framework called multi‐network algorithm‐driven drug repositioning targeting ICP (Mnet‐DRI) is developed to accurately repurpose novel ICIs from ≈3000 Food and Drug Administration‐approved or investigational drugs. By applying Mnet‐DRI to PD‐L1, maprotiline (MAP), an antidepressant drug is repurposed, as a potential PD‐L1 modifier for colorectal and lung cancers. Experimental validation revealed that MAP reduced PD‐L1 expression by targeting E3 ubiquitin ligase speckle‐type zinc finger structural protein (SPOP), and the combination of MAP and anti‐CTLA4 in vivo significantly enhanced the antitumor effect, providing a new alternative for the clinical treatment of colorectal and lung cancer.