bluuebunny/crossref_metadata_2025_split huggingface dataset:
Genetic integration of behavioural and endocrine components of the stress response
Authors: Houslay T.M. , Earley R.L. , White S.J. , Lammers W. , Grimmer A.J. , Travers L.M. , Johnson E.L. , Young A.J. , Wilson A.J. 
Published: September 2019

AbstractThe vertebrate stress response comprises a suite of behavioural and physiological traits that must be functionally integrated to ensure organisms cope adaptively with acute stressors. Natural selection should favour functional integration, leading to a prediction of genetic integration of these traits. Despite the implications of such genetic integration for our understanding of human and animal health, as well as evolutionary responses to natural and anthropogenic stressors, formal quantitative genetic tests of this prediction are lacking. Here we demonstrate that acute stress response components in Trinidadian guppies are both heritable and integrated on the major axis of genetic covariation. This integration could either facilitate or constrain evolutionary responses to selection, depending upon the alignment of selection with this axis. Such integration also suggests artificial selection on the genetically correlated behavioural responses to stress could offer a viable non-invasive route to the improvement of health and welfare in captive animal populations.
Fit for purpose? Exploring competence in quality management
Authors: Martin Jason , Elg Mattias , Gremyr Ida 
Published: September 2019

PurposeThe purpose of this paper is to use competence theory to explore the fit between actual competencies of quality management (QM) practitioner and the perception of QM competence needs in organisations.Design/methodology/approachThis paper is based on a cross-case quantitative study design featuring a survey of QM practitioners (n = 249) within eight large Swedish organisations. The research instrument was a questionnaire covering seven themes within QM. The analysis is based on descriptive statistics.FindingsThe results show that while the perception of formal QM competence may seem sufficient, the evolving nature of QM requires knowledge, skills and attitudes that are also apt for more external and explorative perspectives. There is a bias towards competence for exploitative QM rather than explorative QM. Organisational logics preserving and possibly reinforcing a perceived “competence lag” in organisations are identified and described.Originality/valueFew empirical studies within QM explore the competencies required for QM practices. This paper contributes to QM research in providing arguments for adopting the competence theory as a foundation for organising current and future QM work.
A house of sustainability-based approach for green product design
Authors: Upadhyay Parijat , Kumar Anup 
Published: September 2019

PurposeInvestors are looking for the organizations which have robust strategy and planning method meeting the current and future guidelines and policies on environmental regulations to improve sustainability. Thus, most of the business units have been striving to incorporate sustainability into process and product or service design in such a way that carbon footprint should be minimized. Sustainable product and service design remain a challenge for industrial organizations because of the involvement of multifaceted factors in the design endeavor. The purpose of this paper is to develop a methodology to include sustainability functions at the design phase of the product or process.Design/methodology/approachThe authors have modified the house of quality concept, and grey relational analysis-house of sustainability process is proposed in this paper, which includes consideration of all sustainability dimensions including environmental at the design phase of the product or process development. The process has been explained with an example of retail service design.FindingsThe proposed approach incorporates the specific business environment and the type of product to be designed with all three levels of sustainability by design. By capturing all sustainability dimensions in the design stage itself, various issues may be taken care of at the initial stage of operations, which are likely to affect sustainability in all activities of the supply chain and the organization as a whole. Thus the proactive sustainable designing considerably eases and improves the sustainability reporting and meeting the legislative guidelines prescribed by the governmental agencies of the country.Originality/valueA novel methodology has been proposed to include sustainability functions at the design phase, which is strategically useful for sustainable operations and to develop a sustainable product or process.
What is the Main Processing Factor Influencing Staphylococcus Species Diversity in Different Manufacturing Units?
Authors: Fraqueza Maria João , Rocha João Miguel , Laranjo Marta , Potes Maria Eduarda , Fialho Ana Rita , Fernandes Maria José , Fernandes Maria Helena , Barreto António , Semedo‐Lemsaddek Teresa , Elias Miguel 
Published: September 2019

AbstractThe microbiota of traditional dry‐cured sausages and industrial environment was assessed to characterize the diversity of coagulase‐negative staphylococci (CNS), and establish potential relationships with hygiene level or technological characteristics. Eight processing units from South Portugal were audited according to a checklist of requirements. Environmental and products’ samples at different production stages were evaluated regarding hygiene and safety criteria. CNS were recovered, characterized, and their potential use as starters evaluated. Low genetic diversity was observed for Staphylococcus xylosus, whereas Staphylococcus equorum showed diverse genetic profiles. Staphylococcus xylosus predominated in products with a long period of cold smoking, Staphylococcus saprophyticus in products with a long period of hot smoking, Staphylococcus epidermidis in products with a short period of cold smoking, and S. equorum in nonsmoked products. Most S. xylosus were resistant to tetracycline, whereas S. equorum were susceptible. Antibioresistance restricted the selection of starters due to safety recommendations.Practical ApplicationThe present manuscript highlighted a few staphylococci strains that could potentially be used as starter cultures in fermented meat products. These selected strains do not show resistance to antimicrobials, exhibit adequate technological features, and are well adapted to the industrial environments of meat processing industries using different processing technologies. Therefore, the selected strains ready to be used in the manufacturing of traditional fermented meat products to ensure safety, standardize product properties, and shorten ripening.
Assessment of Acute Motor Effects and Tolerance Following Self‐Administration of Alcohol and Edible ∆9‐Tetrahydrocannabinol in Adolescent Male Mice
Authors: Smoker Michael P. , Hernandez Maribel , Zhang Yanping , Boehm Stephen L. 
Published: September 2019

BackgroundCannabinoids and their principle psychoactive target, the cannabinoid type 1 receptor (CB1R), impact a number of alcohol‐related properties, and although alcohol and cannabis are often co‐used, particularly in adolescence, few animal models of this phenomenon exist. We modeled the co‐use of alcohol and ∆9‐tetrahydrocannabinol (THC) in adolescent mice using ingestive methods popular during this developmental period in humans, namely binge‐drinking and edible THC. With this model, we assessed levels of use, acute effects, and tolerance to each substance.MethodsAdolescent male C57BL/6J mice had daily, limited access to 1 of 2 edible doughs (THC or control), to 1 of 2 fluids (ethanol (EtOH) or water), and in 1 of 2 orders (dough–fluid or fluid–dough). Home cage locomotor activity was recorded both during access and after access. On the day following the final access session, a subset of mice were assessed for functional and metabolic tolerance to alcohol using accelerating rotarod and blood EtOH concentrations, respectively. The remaining mice were assessed for tolerance to THC‐induced hypothermia, and whole‐brain CB1R expression was assessed in all mice.ResultsEtOH intake was on par with levels previously reported in adolescent mice. Edible THC was well‐consumed, but consumption decreased at the highest dose provided. Locomotor activity increased following EtOH intake and decreased following edible THC consumption, and edible THC increased fluid intake in general. The use of alcohol produced neither functional nor metabolic tolerance to an alcohol challenge. However, the use of edible THC impaired subsequent drug‐free rotarod performance and was associated with a reduction in THC's hypothermic effect.ConclusionsAdolescent mice self‐administered both alcohol and edible THC to a degree sufficient to acutely impact locomotor activity. However, only edible THC consumption had lasting effects during short‐term abstinence. Thus, this adolescent co‐use model could be used to explore sex differences in self‐administration and the impact substance co‐use might have on other domains such as mood and cognition.
Double missense mutations in cardiac myosin‐binding protein C and myopalladin genes: A case report with diffuse coronary disease, complete atrioventricular block, and progression to dilated cardiomyopathy
Authors: Mastroianno Sandra , Palumbo Pietro , Castellana Stefano , Leone Maria Pia , Massaro Raimondo , Potenza Domenico Rosario , Mazza Tommaso , Russo Aldo , Castori Marco , Carella Massimo , Di Stolfo Giuseppe 
Published: September 2019

AbstractCardiomyopathies caused by double gene mutations are rare but conferred a remarkably increased risk of end‐stage progression, arrhythmias, and poor outcome. Compound genetic mutations leading to complex phenotype in the setting of cardiomyopathies represent an important challenge in clinical practice, and genetic tests allow risk stratification and personalized clinical management of patients. We report a case of a 50‐year‐old woman with congestive heart failure characterized by dilated cardiomyopathy, diffuse coronary disease, complete atrioventricular block, and missense mutations in cardiac myosin‐binding protein C (MYBPC3) and myopalladin (MYPN). We discuss the plausible role of genetic profile in phenotype determination.
Extended persistence of antiphospholipid antibodies beyond the 12‐week time interval: Association with baseline antiphospholipid antibodies titres
Authors: Devignes Jean , Smaïl‐Tabbone Malika , Hervé Alex , Cagninacci Geoffroy , Devignes Marie‐Dominique , Lecompte Thomas , Zuily Stéphane , Wahl Denis 
Published: September 2019

AbstractIntroductionThe confirmation time interval for the presence of antiphospholipid antibodies (aPL) has been extended to 12 weeks as epiphenomenal antibodies may disappear after 6 weeks. Our aim was to analyse extended persistence of aPL positivity beyond the 12‐week interval.MethodsWe retrospectively analysed our database of 23 856 aPL test samples collected between 2005 and 2017 from 17 367 consecutive patients. Two groups of patients were identified among aPL‐positive patients, confirmed at 12 weeks: with or without extended persistence beyond confirmatory testing. Percentages of extended persistence are given according to the initial aPL positivity profiles, and baseline laboratory variables are compared between the two groups.ResultsThree hundred and twenty‐seven patients confirmed aPL‐positive had subsequent testing. The vast majority of them displayed extended persistence in the long term: 89.6% and up to 97.9% for patients with initial triple positivity. In extended persistent positive patients, there were more LA‐positive initial samples, and baseline LA test values and IgG aCL titres were higher than in nonpersistent positive patients.ConclusionData from a large database of an aPL referral laboratory showed that the time interval of 12 weeks defining persistence of aPL positivity was appropriate for the majority of patients. Furthermore, we found baseline features associated with extended persistence.
Quality disclosure strategy in a decentralized supply chain with consumer returns
Authors: Feng Zhangwei , Xiao Tiaojun , Yu Yunlong , Robb David J. 
Published: September 2019

AbstractWe study the quality disclosure strategy of a manufacturer/retailer in a supply chain with consumer returns for new products. In particular, we explicitly model the effect of quality disclosure on the reduction of the returns rate. We identify the condition in which the manufacturer/retailer should reveal product quality in the presence of consumer returns. We find that (1) the manufacturer/retailer has an incentive to choose quality disclosure strategy when the disclosure quality is above a lower bound; (2) if the returns rate of new products is low, the retailer‐disclosure scenario leads to reveal more quality information than that of the manufacturer‐disclosure scenario; otherwise, the manufacturer‐disclosure scenario leads to reveal more quality information; and (3) the manufacturer prefers to reveal a higher level of product quality in the supply chain with a higher refund amount or a lower salvage value per unit of returned product.
Extraction and characterization of water‐soluble polysaccharides from Tamarindus indica and Pithecellobium dulce seeds
Authors: Sivakumar Nandhineeswari , Karuppaiyan Kavitha 
Published: September 2019

AbstractWater‐soluble polysaccharides (WSP) were secluded from Tamarindus indica (TWSP) and Pithecellobium dulce (PWSP) seeds by hot water method. The physico‐chemical properties revealed that the polysaccharides might be used as a potential food additive. The micrometric properties of TWSP and PWSP possessed a bulk density of 0.64 and 0.68 g/ml, respectively. The isolated polysaccharides were subjected to Fourier transform infrared spectroscopy and Nuclear magnetic resonance spectroscopy for its compositional analysis and exhibited that both the isolates are heteropolysaccharides. The spectra of both the mucilages were resonating at δ 3.00–δ 5.00 ppm which confirmed the presence of polysaccharides. Thermo gravimetric analysis showed that the isolated polysaccharides were thermally stable. Scanning electron microscopy and X‐ray diffraction depicted the morphological characteristics. The radical scavenging ability and antibacterial activity proved that the polysaccharides can be explored as a functional food ingredient. Furthermore, the prebiotic potential of polysaccharides stimulated the growth of Lactobacillus delbrueckii and Lactobacillus fermentum over inulin.Practical applicationsThe study provides optimum extraction conditions to obtain TWSP and PWSP seeds using response surface methodology. The isolated polysaccharides can be used as therapeutic agent and as a food additive due to its high purity obtained from Fourier transform infrared spectroscopy and Nuclear magnetic resonance spectroscopic analysis. The excellent flowability and compressibility of polysaccharides can be applied in pharmaceutical formulation as an excipient. The active component present in the isolated polysaccharides can be used as a food preservative. The supplement of TWSP and PWSP as a carbon source accelerated the growth of probiotics which could be used as natural prebiotics. Thus the study concluded that the water‐soluble polysaccharide obtained from the agro‐industrial by product has the wide application in food and pharmaceutical industries.
A cost–benefit analysis of the environmental taxation policy in China: A frontier analysis‐based environmentally extended input–output optimization method
Authors: Wang Ke , Wang Jiayu , Hubacek Klaus , Mi Zhifu , Wei Yi‐Ming 
Published: September 2019

AbstractChina's high‐speed economic development and reliance on overconsumption of natural resources have led to serious environmental pollution. Environmental taxation is seen as an effective economic tool to help mitigate air pollution. In order to assess the effects of different scenarios of environmental taxation policies, we propose a frontier‐based environmentally extended input–output optimization model with explicit emission abatement sectors to reflect the inputs and benefits of abatement. Frontier analysis ensures policy scenarios are assessed under the same technical efficiency benchmark, while input–output analysis depicts the wide range of economic transactions among sectors of an economy. Four scenarios are considered in this study, which are increasing specific tax rates of SO2, NOx, and soot and dust separately and increasing all three tax rates simultaneously. Our estimation results show that: raising tax rates of SO2, NOx, and soot and dust simultaneously would have the highest emission reduction effects, with the SO2 tax rate making the greatest contribution to emission reduction. Raising the soot and dust tax rate is the most environmentally friendly strategy due to its highest abatement to welfare through avoided health costs. The combination of frontier analysis and input–output analysis provides policy makers a comprehensive and sectoral approach to assess costs and benefits of environmental taxation.
Update on Research and Practices in Major Sleep Disorders: Part II—Insomnia, Willis‐Ekbom Disease (Restless Leg Syndrome), and Narcolepsy
Authors: Chaiard Jindarat , Weaver Terri E. 
Published: September 2019

AbstractPurposeThis review (Part II of a series on sleep disorders) presents an update of the characteristics, epidemiology, assessment, and latest management of insomnia, restless legs syndrome (Willis‐Ekbom disease; RLS/WED), and narcolepsy. Insomnia, the most common sleep disorder and most prevalent of all psychological health disorders, is a problem of difficulty initiating and maintaining sleep and early morning awakenings. RLS/WED is characterized by a crawling sensation or urge to move the legs in the evening and nighttime. Narcolepsy is a sleep disorder that commonly results in chronic daytime sleepiness and cataplexy. Nonpharmacological management, which includes education, cognitive behavioral therapy, and complementary therapy, is used as primary or adjunctive to pharmacotherapy for the treatment of these disorders.MethodsThis narrative review utilized medical databases such as PubMed to identify relevant English‐language original and systematic review articles predominantly from peer‐reviewed journals from 2012 to 2019. However, as background, findings from classic articles prior to 2012 were also included.Clinical RelevanceAssessment of sleep problems, excessive sleepiness, and difficulty performing activities or being productive should be routine in the care of all patients. Utilization of behavioral interventions, including cognitive behavioral therapy, in addition to education and sleep hygiene, can promote sleep quality. Management of insomnia, RLS/WED, and narcolepsy should include helping patients adjust to treatment, managing cataplexy triggers in narcolepsy, and initiating strategies to live with chronic illness to improve quality of life.
The effect of 1540‐nm fractional erbium‐glass laser in the treatment of androgenic alopecia
Authors: Alhattab Mohammed K. , AL Abdullah Mohammad J. , Al‐janabi Murtadha H. , Aljanaby Wejdan A. , Alwakeel Hadi A. 
Published: September 2019

AbstractBackgroundAndrogenic alopecia is common, chronic dermatologic disorder. A variety of lasers and light sources appear to be safe and effective in the treatment of AGA.AimsTo evaluate the efficacy and safety of 1540‐nm fractional erbium glass laser in the treatment of AGA.Patients/MethodsThis was an interventional therapeutic study for the treatment of patients with AGA. The patients received 10 sessions with 1540‐nm fractional erbium glass laser at 2‐week intervals. The assessment of the response was done before and at the end of follow‐up period, both objectively (the change in the density of terminal hair and the diameter of the hair shaft) and subjectively (patient satisfaction). Any adverse effects were documented during the study.ResultsForty‐seven out of 51 patients completed the study. After 5 months of laser treatment, the density of hair and hair thickness was significantly increased in both males and females (P value .001).ConclusionThe 1540‐nm fractional erbium‐glass laser seems to be an effective and safe option for treatment of patients with AGA. The improvement was accomplished in a short period.
THE OLIGOCENE–MIOCENE MENILITE FORMATION IN THE UKRAINIAN CARPATHIANS: A WORLD‐CLASS SOURCE ROCK
Authors: Rauball J. F. , Sachsenhofer R. F. , Bechtel A. , Coric S. , Gratzer R. 
Published: September 2019

This study investigates the hydrocarbon potential of Oligocene–Miocene shales in the Menilite Formation, the main source rock in the Ukrainian Carpathians. The study is based on the analysis of 233 samples collected from outcrops along the Chechva River in western Ukraine in order to analyse bulk parameters (TOC, Rock‐Eval), biomarkers and maceral composition.In Ukraine, the Menilite Formation is conventionally divided into Lower (Lower Oligocene), Middle (Upper Oligocene) and Upper (Lower Miocene) Members. The Early Oligocene and Early Miocene ages of the lower and upper members are confirmed by new nannoplankton data. The Lower Menilite Member is approximately 330 m thick in the study area and contains numerous chert beds and turbidite sandstones in its lower part together with organic‐rich black shales. The shales have a high content of silica which was probably derived from siliceous micro‐organisms. The TOC content of the shales frequently exceeds 20 wt.% and averages 9.76 wt.%. HI values range between 600 and 300 mgHC/gTOC (max. 800 mgHC/gTOC). The Middle Member contains thin black shale intervals but was not studied in detail. The Upper Member is about 1300 m thick in the study area and is composed mainly of organic‐rich shales. Chert layers are present near the base of the Member, and a prominent tuff horizon in the upper part represents a volcanic phase during shale deposition. The member grades into overlying molasse sediments. The average TOC content of the Upper Menilite succession is 5.17 wt.% but exceeds 20 wt.% near its base.Low Tmax and vitrinite reflectance measurements for the Lower (419°C and 0.24–0.34 %Rr, respectively) and Upper (425°C and 0.26–0.32 %Rr, respectively) Menilite Member successions indicate thermal immaturity. Biomarker and maceral data suggest a dominantly marine (Type II) organic matter input mixed with varying amounts of land‐plant derived material, and indicate varying redox and salinity conditions during deposition.Determination of the Source Potential Index (SPI) shows that the Menilite Formation in the study area has the potential to generate up to 74.5 tons of hydrocarbons per m2. The Chechva River outcrops therefore appear to have a significantly higher generation potential than other source rocks in the Paratethys realm. These very high SPI values for the Menilite Formation may explain why a relatively small area in Ukraine hosts about 70% of the known hydrocarbon reserves in the northern and eastern Carpathian fold‐thrust belt.