bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of MITF, SOX10, MART-1, and R21 Immunostaining for the Diagnosis of Residual Melanoma In Situ on Chronically Sun-Damaged Skin
Authors: Mu Euphemia W. , Quatrano Nicola A. , Yagerman Sarah E. , Ratner Desiree , Meehan Shane A. 
Published: February 2018

BACKGROUND
Melanocytic immunostains can assist in margin evaluation of melanoma in situ (MIS) excisions; however, their accuracy and reliability relative to hematoxylin & eosin (H&E) is yet to be determined.

OBJECTIVE
The objective of this study was to evaluate the sensitivity, specificity, and concordance of 4 melanocyte-specific immunostains for diagnosing MIS occurring on chronically sun-damaged skin.

MATERIALS AND METHODS
Serial permanent sections from representative areas of negative margin and residual tumor were stained using H&E, MITF, MART-1, SOX10, and R21 and examined in a blinded fashion. The study set included 100 digital microscopy images from 10 cases of MIS excisions from the face. Two board-certified dermatopathologists, 4 fellowship-trained Mohs surgeons, 2 Mohs fellows, and 2 dermatology residents independently reviewed the 100 images.

RESULTS
The average melanocyte density was 11 versus 28 melanocytes per 0.5 mm for chronically sun-damaged skin versus residual MIS on H&E, respectively. Statistically significantly higher melanocyte densities were observed using MITF, MART-1, and SOX10 on negative margins. The sensitivity and interobserver concordance was highest using MITF and SOX10. The intraobserver agreement on 4 duplicate images was 85%.

CONCLUSION
In conclusion, the nuclear immunostains (MITF and SOX10) show the most promise for improving the diagnosis of MIS in chronically sun-damaged skin.
Detection of Drug-Exposed Newborns
Authors: Wabuyele Simuli L. , Colby Jennifer M. , McMillin Gwendolyn A. 
Published: February 2018

Abstract:
Maternal substance abuse during pregnancy is a growing problem with major public health and legal concerns. In utero substance exposure may adversely affect neonatal development; pregnancy outcome; and the long-term behavioral, cognitive, and developmental abilities of the child. Also, serious legal implications are associated with substance abuse during pregnancy, including charges of child abuse and neglect that may result in the removal of the neonate from parental care and loss of custodial rights. Timely detection of in utero drug exposure is necessary for early identification and effective management of exposed newborns. Accurate identification of drug-exposed newborns relies on maternal history; clinical presentation of the newborn; and laboratory testing of biological maternal matrices (ie, urine, blood, oral fluid, sweat, hair, and breast milk), neonatal matrices (ie, urine, meconium, hair, and umbilical cord blood and tissue), and/or matrices from both the mother and neonate (ie, placenta and amniotic fluid). Evaluation of biological matrices can account for in utero exposure at various stages of gestation and approximate the period (recent versus chronic use) of substance exposure. Each matrix has its own unique advantages and limitations in terms of ease of collection, the window of gestational exposure represented, and sensitivity for different parent drug analytes and metabolites, which must be carefully considered for accurate interpretation of results. Analytical approaches to sample preparation and analysis vary based on the complexity of these biological matrices. Immunoassays are routinely used for screening, and chromatographic separation coupled to mass spectrometry detection method is commonly used for definitive (confirmatory) testing. Some laboratories use a single technology for all testing. This review provides a discussion on approaches used to detect drug-exposed newborns, biological specimens that have been studied to identify and characterize drug exposures, example analytical methods for meconium and umbilical cord tissue as well as considerations surrounding the interpretation of results. A possible algorithm for testing is also proposed.
Short article: Endoscopic ultrasound-guided fine-needle aspiration of portal vein thrombosis in patients with chronic liver disease and suspicion of hepatocellular carcinoma
Authors: Gimeno Garcia Antonio Z. , Aparicio Jose R. , Barturen Angel , Moreno Miguel , Nicolas-Perez David , Quintero Enrique 
Published: February 2018

Background
Differentiation between benign and malignant portal vein thrombosis (PVT) in the setting of a hepatocellular carcinoma (HCC) is of paramount importance. Histological analysis is usually not carried out because of potential severe side effects of the percutaneous approach. Endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) may be safer and may guide the clinical management of patients with HCC.

Objective
To describe the feasibility of the EUS-FNA in a series of patients with HCC and PVT.

Materials and methods
A chart review of patients with PVT was performed from 2014 to 2016 in three tertiary care hospitals of Spain. Patients with chronic liver disease and PVT with a suspicion of HCC referred for EUS-FNA were included. The impact of the EUS-FNA was assessed by comparing staging following the Barcelona Clinic Liver Cancer algorithm (BCLC) before and after EUS-FNA.

Results
Of 104 patients with PVT and chronic liver disease, 23 were considered candidates for EUS-FNA. Eight patients were referred for EUS-FNA. The technique was feasible in seven patients and FNA was positive in six patients. No side effects were reported. EUS-FNA upstaged six out of seven (85.7%) patients: one patient BCLC stage B, two patients BCLC stage A, and three patients in whom the HCC was not diagnosed before EUS-FNA of the PVT. A benign PVT was found in the explant of the only patient with a negative PVT.

Conclusion
EUS-FNA is a valuable technique in selected patients with chronic liver disease with PVT. It is feasible, safe, and may alter the clinical management in these patients.
The Development of Defense Mechanisms During the Latency Period
Authors: Cramer Phebe 
Published: February 2018

Abstract
The developmental period of latency, during middle childhood, has not been previously studied for possible change in the use of defense mechanisms. Using a validated narrative method to assess defenses, the present research examines change in children's defense use during this period. As predicted from theory, there was a significant increase in the use of the defense of Identification. This finding is consistent with theory that posits a shift at this time from defense against anxiety that is based on lack of impulse control to defense that is based on anxiety due to violation of conscience.
Outcomes of Clinical Nurse Specialist Practice in the Implementation of Video Monitoring at an Academic Medical Center
Authors: Purvis Suzanne , Kaun Alazda , McKenna Andrea , Weber Viste Jessica , Fedorov Emilie 
Published: February 2018

Purpose/Objectives:
The purpose of this project was to design and implement a program that utilizes video cameras with the goal of monitoring for and preventing unsafe patient events that can lead to poor outcomes.

Description of the Project:
The Concerns-Based Adoption Model was utilized to address users’ concerns in different stages of diffusion of the new technology. Clinical nurse specialists, as part of a Constant Observation Workgroup, addressed these concerns during initial development and subsequent implementation of video monitoring on adult inpatient units. Establishing initiation criteria for video monitoring and documentation in the electronic health record was critical to success of the project.

Outcomes:
Video monitoring was successfully implemented on 8 inpatient units. A decline in full-time employment numbers for 1:1 sitters was demonstrated with no increase in fall numbers.

Conclusions:
Clinical nurse specialists were successful in collaborating with interdisciplinary colleagues to support the development of a Constant Observation Program that included video monitoring. In addition, clinical nurse specialists developed documentation, policies, and procedures to support this new technology. Success was evidenced by support of and growth of the program over time.
Brief Report: Statin Effects on Myocardial Fibrosis Markers in People Living With HIV
Authors: deFilippi Christopher , Christenson Robert , Joyce Jessica , Park Elli A. , Wu Ashley , Fitch Kathleen V. , Looby Sara E. , Lu Michael T. , Hoffmann Udo , Grinspoon Steven K. , Lo Janet 
Published: February 2018

Background:
In observational studies, patients with HIV have higher levels of soluble ST2 (sST2), galectin-3, and growth differentiation factor-15 (GDF-15) than non-HIV controls. As statins exert pleiotropic immunomodulatory effects that may affect markers of myocardial fibrosis, the objective of the current study is to determine whether biomarkers of myocardial fibrosis reflecting subclinical pathology may be modified by statin therapy in patients with HIV.

Setting and Methods:
Forty HIV+ men and women participated in a single center 12-month randomized, double-blind placebo-controlled trial of atorvastatin 40 mg every day vs. placebo. At baseline and 12-months, sST2, GDF-15, galectin-3 were measured.

Results:
The changes in sST2 were −0.310 (−4.195, 2.075) vs. 1.163 (0.624, 4.715) ng/mL, median (interquartile range) atorvastatin vs. placebo (P = 0.04). The change in sST2 was significantly related to changes in monocyte activation marker sCD14 (r = 0.63, P < 0.0001) and MCP (r = 0.52, P = 0.0009), markers of generalized inflammation hs-IL-6 (r = 0.58, P = 0.0002), oxLDL (r = 0.49, P = 0.002), and GDF-15 (r = 0.54, P = 0.0008).

Conclusions:
sST2, a member of the IL-1 receptor family and a marker of fibrosis and inflammation increases over time among patients with HIV and this increase is attenuated by statin therapy in HIV. This effect may relate to immunomodulatory mechanisms of statins.
Recurrence of Giant Cell Tumor of The Larynx
Authors: Acikalin Resit Murat , Özsan Ayşe Vildan , Alimoglu Yalcin , Gezginadam Zafer , Yanik Huseyin Tarik , Coskun Samet Cagri , Kaya Hasan 
Published: February 2018

Abstract
Giant cell tumor of the larynx is a rare tumor. It was first reported by Wessely et al in 1940. Thirty-nine cases have been reported until now and together with the current case 2 recurrences were encountered. In this case report, our aim was to discuss conservative management because of the suspicion of recurrence. A 70-year-old male patient was admitted to our clinic with the complaint of hoarseness. A tumor measuring 1 × 1 cm located in the anterior half right vocal fold and extending to the anterior comissure was found on laryngeal endoscopy. Direct laryngoscopy and biopsy of the mass revealed giant cell tumor on histopathological examination. Tumor resection with cordectomy through laryngofissure and subsequently medialization thyroplasty were performed. Horaseness of the patient improved. On 2-year follow-up, a tumoral lesion suggesting recurrence was found on the vocal cord. Direct laryngoscopy and biopsy confirmed recurrence. Total laryngectomy was performed. This is the second case of recurrent giant cell tumor of the larynx. The therapy of choice should be selected considering the possibility of recurrence.
Orbital Cavernous Hemangioma Causing Spontaneous Compressive Hemorrhage
Authors: Bachelet Jean-Thomas , Berhouma Moncef , Shipkov Hristo , Kodjikian Laurent , Jouanneau Emmanuel , Gleizal Arnaud 
Published: February 2018

Abstract
Cavernous hemangiomas are the most common tumors of the posterior cone of the orbit in adults. They are discovered in a fortuitous manner or in front of the appearance of a progressive exophthalmia.
The authors report through a complete literature review (PubMed) patients of retro-orbital cavernous hemangioma revealed by spontaneous compressional hemorrhage from 1984 to 2017.
This review is illustrated by a case of sharp decrease in visual acuity secondary to orbital cavernous hemangioma hemorrhage.
The authors detail the management and the evolution of all these patients.
Application of Micromirror in Microsurgical Clipping to the Intracranial Aneurysms
Authors: Zhao Chao , Ma Zhiguo , Zhang Yuhai , Mou Shanling , Yang Yunxue , Yang Yonglin , Sun Guoqing , Yao Weicheng 
Published: February 2018

Objective:
The aim of the study was to explore the values and disadvantages of micromirror in the intracranial aneurysm clipping surgery.

Methods:
Micromirror was used to assist microsurgical clipping to 36 intracranial aneurysms in 31 patients, of which 3 were carotid-ophthalmic artery aneurysms, 3 were anterior choroidal artery aneurysms, 11 were posterior communicating artery aneurysms, 7 were middle cerebral artery aneurysms, 10 were anterior communicating artery or anterior cerebral artery aneurysms, and the rest were a posterior cerebral artery aneurysm and a posterior inferior cerebellar artery aneurysm. The micromirror was used before and after clipping to observe the anatomic features of necks hidden behind and medial to aneurysms, to visualize surrounding neurovascular structures, and to verify the optimal clipping position. Intraoperative indocyanine green fluorescein angiography, postoperative computerized tomography angiography, and digital subtraction angiography confirmed the success of sufficient clipping.

Results:
Intraoperative indocyanine green angiography, postoperative computerized tomography angiography , or digital subtraction angiography were performed and showed no case of wrong or insufficient clipping of aneurysm.

Conclusions:
Micromirror-assisted microsurgical clipping to the intracranial aneurysm is safe, sufficient, convenient, and practical.
Merkel Cell Carcinoma of the Cheek
Authors: Sisti Andrea , Brandi Cesare , Grimaldi Luca , Pica Alfieri Edoardo , Cuomo Roberto , Zerini Irene , Nisi Giuseppe 
Published: February 2018

Abstract
Merkel cell carcinoma (MCC) is a rare and aggressive skin cancer with a neuroendocrine phenotype. Here, the authors reported a case of MCC, presented as a rapidly growing, asymptomatic, erythematous nodule measuring 3.8 cm × 2.8 cm in diameter on the right cheek of an 85-year-old Caucasian woman. After resection of the nodule, the defect was repaired with cutaneous graft taken from the supraclavicular area and healed uneventfully. Histopathologic examination confirmed the diagnosis of MCC.
Clinical Practice Recommendations for Continuation and Maintenance Electroconvulsive Therapy for Depression
Authors: Gill Shane P. , Kellner Charles H. 
Published: February 2018

Objectives
Continuation or maintenance electroconvulsive therapy (ECT) is often provided as a strategy for post-ECT relapse prevention. However, the evidence has been insufficient until recently to produce clear consensus on what best practice maintenance ECT (mECT) should be like in a real world ECT clinical service. The aims of this article are to help fill this gap and to provide a comprehensive set of practical, clinically-based recommendations for ECT clinicians and services.

Methods
A workshop was held at the Royal Australian and New Zealand College of Psychiatry Congress in Adelaide on April 30, 2017. This workshop was hosted by the authors. After a presentation on the state of the evidence, the 30 participants were asked to work in small groups to develop consensus recommendations on different aspects of mECT. These were then collated into one comprehensive set of clinical recommendations for the practice of mECT.

Results
These best practice recommendations are set out below.

Conclusions
These recommendations will assist ECT services and clinicians to provide best practice mECT according to currently available evidence.
Social capital as a new board diversity rationale for enhanced corporate governance
Authors: Booth-Bell Darlene 
Published: February 2018

PurposeThe benefits of board diversity are often categorized into five distinct business rationales: talent rationale, market rationale, litigation rationale, employee relations rationale and governance rationale. However, if resource dependency theory’s focus on the director’s ability to secure important resources for the firm is considered, social capital as a viable additional rationale for board diversity can also be considered. The purpose of this paper is to argue that diverse members of the board are likely to have social capital that differs from non-diverse members of the board. Consequently, that diverse social capital can bridge the board to new resources for advice and counsel, legitimacy, channels for communication and access to important external elements, thus making a strong argument to be included as a rationale for board diversity.Design/methodology/approachIt is intended to provide a conceptual discussion on whether enhancing the board’s social capital is perhaps a viable and overlooked rationale for board diversity.FindingsConsistent with the other five rationales for board diversity, this analysis suggests that social capital should be considered as a sixth rationale for board diversity. Social capital serves a role in governance and rises to the standard of other rationales for board diversity.Practical implicationsBoards may not recognize that social capital is a strategic resource and sufficiently diverse groups such as women and minorities may be more likely to contribute non-overlapping social capital networks, which may translate into greater external influence and thus additional resources for the firm. This paper may help to influence the viewpoints of directors on who is valuable as a board member.Originality/valueExisting board diversity rationales do not include social capital as a primary rationale for board diversity. It may be possible that social capital becomes a legitimate sixth rationale for board diversity.
A cross-country comparison and validation of firms’ stakeholder considerations in sustainable business practices
Authors: Karlsson Niklas P.E. , Laurell Hélène , Lindgren John , Pehrsson Tobias , Andersson Svante , Svensson Göran 
Published: February 2018

PurposeThe purpose of this study is to compare and validate firms’ internal and external stakeholder considerations in sustainable business practices across business settings. It aims to assess the validity and reliability of a stakeholder framework appearing in previous studies.Design/methodology/approachThe study uses a questionnaire survey and a cross-industry sample consisting of the largest firms in corporate Sweden. Multivariate analysis tests the stakeholder framework. Each of the 294 key informants was initially identified and contacted by telephone, generating a response rate of 36.5 per cent.FindingsThe tested stakeholder framework appears valid and reliable across countries to assess the internal stakeholders of focal firms, as well as their up- and downstream, market and societal stakeholders. This study provides additional empirical support to categorize firms’ stakeholder considerations in sustainable business practices.Research limitations/implicationsThis study validates previous findings in terms of Swedish firms’ considerations of internal and external stakeholders in sustainable business practices in relation to one similar country (Norway) and one different country (Spain). The study also shows how the three countries perceive the focal company and societal stakeholders differently.Practical implicationsThe tested framework sheds light on focal firms’ stakeholder considerations in sustainable business practices and elucidates the extent to which firms’ account for their internal and external stakeholders in sustainable business practices.Originality/valueThis study contributes to the development of valid and reliable stakeholder theory across contexts and through time. In particular, it contributes to the development of a valid and reliable framework to categorize firms’ stakeholder considerations in sustainable business practices.
Why Trump and Clinton won and lost: the roles of hypermasculinity and androgyny
Authors: Powell Gary N. , Butterfield D. Anthony , Jiang Xueting 
Published: February 2018

PurposeThe purpose of this paper is to examine perceptions of the “Ideal President” (IP) and presidential candidates in the 2016 US presidential election in relation to gender stereotypes and leader prototypes.Design/methodology/approachIn all, 378 business students assessed perceptions of either the IP or a particular candidate on measures of masculinity and femininity. Androgyny (balance of masculinity and femininity) and hypermasculinity (extremely high masculinity) scores were calculated from these measures.FindingsThe IP was perceived as higher in masculinity than femininity, but less similar to the male (Donald Trump) than the female (Hillary Clinton) candidate. IP perceptions were more androgynous than in the 2008 US presidential election. Respondents’ political preferences were related to their IP perceptions on hypermasculinity, which in turn were consistent with perceptions of their preferred candidate.Social implicationsTrump’s high hypermasculinity scores may explain why he won the electoral college vote, whereas Clinton’s being perceived as more similar to the IP, and IP perceptions’ becoming more androgynous over time, may explain why she won the popular vote.Originality/valueThe study extends the literature on the linkages between gender stereotypes and leader prototypes in two respects. Contrary to the general assumption of a shared leader prototype, it demonstrates the existence of different leader prototypes according to political preference. The hypermasculinity construct, which was introduced to interpret leader prototypes in light of Trump’s candidacy and election, represents a valuable addition to the literature with potentially greater explanatory power than masculinity in some situations.
Trumped up data
Authors: Gossett Charles W. 
Published: February 2018

Purpose
The purpose of this paper is to review recent practices by members of the Trump administration that may impact the ability of diversity researchers to have access to data in the coming years.

Design/methodology/approach
This is a viewpoint essay based largely on current news reports and does not rely on original research.

Findings
While there are strong reasons for concern that the collection, dissemination, and analysis of government data may negatively affect the ability to conduct research, the findings are still primarily speculative and not conclusive.

Research limitations/implications
To the extent that researcher rely on the creation of and access to data generated by federal government agencies, there could be challenges to answering new research questions and/or doing research that compares the present to the past.

Practical implications
Researchers may want to take steps to protect their access to government data by downloading those databases that are most crucial for their work.

Originality/value
This viewpoint article represents only the author’s reflection on what might happen in the future based on what has happened so far.