bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of compounded aqueous milbemycin oxime: issues with formulation potency and reproducibility
Authors: Cochrane Z. N. , Berger D. J. , Viall A. K. , Schrunk D. , (Hans) Coetzee J. F. 
Published: July 2018

ObjectivesTo determine the potency and reproducibility of milbemycin oxime when compounded as an aqueous suspension (20 mg/mL).Materials and MethodsPreparation choice reflected current prescribing practices. Samples were acquired by prescription from two national veterinary compounding pharmacies at three time points. Two different storage conditions were evaluated and sampled at four time points from the order date (day 7, 14, 21 and 28). Milbemycin oxime recovery was performed by solid‐phase extraction and concentration strength measured via high‐performance liquid chromatography.ResultsThe average concentration on day 7 for Pharmacy A samples was 16.29 mg/mL [confidence interval (CI): 15.66 to 16.92] with a coefficient of variation (CV) = 11%, while for Pharmacy B it was 20.46 mg/mL (CI: 19.83 to 21.08) with CV = 22%. The mean decrease in concentration over 28 days for Pharmacy A was 22% (CI: 9% to 34%) while Pharmacy B was 18% (CI: 2% to 35%).Clinical SignificanceThe compounded milbemycin oxime suspensions evaluated in this study deviated by more than 10% from their labelled strength in five of the six lots. Clinical efficacy of compounded milbemycin oxime suspensions remains unknown and the use of these products should be discouraged at this time.
Collective interviewing: The use of a model statement to differentiate between pairs of truth‐tellers and pairs of liars
Authors: Vernham Zarah , Vrij Aldert , Leal Sharon 
Published: July 2018

PurposeThe current experiment examined the use of a model statement for aiding lie detection and gathering additional information during interviews in which pairs of suspects were interviewed together (i.e., collective interviewing). A model statement is an example of an answer, unrelated to the topic under investigation, which is played to suspects to demonstrate how much information the interviewer wants them to provide in response to the question asked.MethodPairs of truth‐tellers visited a restaurant together, whereas pairs of liars completed a mock crime. The task for all pairs was to convince an interviewer that they were visiting a restaurant together at the time the crime was committed. Half the truth‐telling pairs and half the lying pairs were exposed to a model statement, whilst the other halves were not.ResultsTruth‐telling pairs were more detailed and showed more interactions than lying pairs, particularly in the model statement present condition.ConclusionsBeing exposed to a model statement in a collective interview magnified the differences between pairs of truth‐tellers and pairs of liars in reporting detail and interacting with one another. A model statement is simple to implement and can be applied to many real‐world investigative interviewing settings whereby the focus is on lie detection and gathering as much information as possible.
Stagnating trends in complementary feeding practices in Bangladesh: An analysis of national surveys from 2004‐2014
Authors: Na Muzi , Aguayo Víctor M. , Arimond Mary , Narayan Anuradha , Stewart Christine P. 
Published: July 2018

AbstractBangladesh has experienced steady socio‐economic development. However, improvements in child growth have not kept pace. It is important to document complementary feeding (CF) practices—a key determinant of children's growth—and their trends over time. The study aims to examine trends in CF practices in children aged 6–23 months using data from Bangladesh Demographic and Health Surveys conducted in 2004, 2007, 2011, and 2014. Multilevel logistic regression models were applied to identify independent predictors of four CF practice indicators among children 6–23 months, namely, timely introduction of complementary foods, minimum meal frequency, minimum dietary diversity, and minimum acceptable diet. Introduction of complementary foods was achieved among 64–71% of children between 2004 and 2014. The proportion meeting minimum meal frequency increased from 2004 to 2007 (71–81%) and declined and held steady at 65% from 2011 to 2014. The proportion meeting minimum dietary diversity in 2011 and 2014 was low (25% and 28%), and so was minimum acceptable diet (19% and 20%). From 2007 to 2014, child dietary diversity decreased and the most decline was in the consumption of legumes and nuts (29% to 8%), vitamin A‐rich fruits and vegetables (54% to 41%), and other fruits and vegetables (47% to 20%). Young child age (6–11 months), poor parental education, household poverty, and residence in the Chittagong and Sylhet independently predicted poorer feeding practices. Dietary diversity and overall diet in Bangladeshi children are strikingly poor. Stagnation or worsening of feeding practices in the past decade are concerning and call for decisive policy and programme action to address inappropriate child feeding practices.
A Latent Curve Model Approach To Studying L2 N‐Gram Development
Authors: GARNER JAMIE , CROSSLEY SCOTT 
Published: July 2018

AbstractCurrent quantitative methods in second language (L2) acquisition have proven useful in examining how phraseological unit production changes over time. However, these methods are limited in that they do not allow for the analysis of individual differences in those changes. This study demonstrates the potential for Latent Curve Modeling, a type of Structural Equation Modeling, to address questions about productive phraseological knowledge development. It examines growth in multiple indices of bigram and trigram use (frequency, association strength, proportion) in the spoken output of L2 speakers over the course of a 4‐month study. Results for unconditional latent curve models indicate that spoken bigram and trigram proportions increased for the entire group over the study period. Conditional latent curve models showed that growth in bigram frequency and bigram proportion was predicted by proficiency, with less proficient writers experiencing greater growth. These models also demonstrated that conversation dyad predicted growth in spoken bigram frequency in that L2 speakers with L2 conversation partners, as compared to first language (L1) partners, produced more high‐frequency bigrams over time. These results have implications for research on L2 productive phraseological knowledge development specifically and longitudinal L2 research in general.
Multi‐omics analyses reveal epigenomics basis for cotton somatic embryogenesis through successive regeneration acclimation process
Authors: Li Jianying , Wang Maojun , Li Yajun , Zhang Qinghua , Lindsey Keith , Daniell Henry , Jin Shuangxia , Zhang Xianlong 
Published: July 2018

SummaryPlant regeneration via somatic embryogenesis is time‐consuming and highly genotype‐dependent. The plant somatic embryogenesis process provokes many epigenetics changes including DNA methylation and histone modification. Recently, an elite cotton Jin668, with an extremely high regeneration ability, was developed from its maternal inbred Y668 cultivar using a Successive Regeneration Acclimation (SRA) strategy. To reveal the underlying mechanism of SRA, we carried out a genome‐wide single‐base resolution methylation analysis for nonembryogenic calluses (NECs), ECs, somatic embryos (SEs) during the somatic embryogenesis procedure and the leaves of regenerated offspring plants. Jin668 (R4) regenerated plants were CHH hypomethylated compared with the R0 regenerated plants of SRA process. The increase in CHH methylation from NEC to EC was demonstrated to be associated with the RNA‐dependent DNA methylation (RdDM) and the H3K9me2‐dependent pathway. Intriguingly, the hypomethylated CHH differentially methylated regions (DMRs) of promoter activated some hormone‐related and WUSCHEL‐related homeobox genes during the somatic embryogenesis process. Inhibiting DNA methylation using zebularine treatment in NEC increased the number of embryos. Our multi‐omics data provide new insights into the dynamics of DNA methylation during the plant tissue culture and regenerated offspring plants. This study also reveals that induced hypomethylation (SRA) may facilitate the higher plant regeneration ability and optimize maternal genetic cultivar.
Clinical studies evaluating abametapir lotion, 0.74%, for the treatment of head louse infestation
Authors: Bowles Vernon M. , VanLuvanee Lisa Jenkins , Alsop Hugh , Hazan Lydie , Shepherd Katie , Sidgiddi Srinivas , Allenby Kent , Ahveninen Tiina , Hanegraaf Sharon 
Published: July 2018

AbstractBackgroundThere is a need for better control of head louse infestations. Abametapir is an inhibitor of metalloproteinases critical for louse survival and egg development. The efficacy of abametapir lotion, 0.74%, was assessed for its ability to clear head louse infestations after a single application.MethodsTwo randomized, double‐blind, multicenter, vehicle‐controlled studies were conducted in subjects aged 6 months and older to compare the effectiveness of abametapir lotion versus vehicle control for eliminating head louse infestations without nit combing. Abametapir lotion was applied to dry hair for 10 minutes on day 0 and then rinsed with water. The primary endpoint was the proportion of index subjects (youngest household member with ≥ 3 live lice at screening) in the intent‐to‐treat population who were louse free at all follow‐up visits through day 14. Older household members with one or more live lice at screening were designated as nonindex subjects and treated as per the index subject within their household.ResultsIn the intent‐to‐treat population (index subjects, N = 216), 81.5% of subjects treated with abametapir lotion were louse free through day 14 after a single treatment, versus 49.1% with vehicle (P < 0.001). For the combined index and nonindex population (N = 704), 85.9% were louse free through day 14 in the abametapir group, versus 61.3% in the vehicle group (P < 0.001). The most frequently reported adverse events were erythema (4.0%), rash (3.2%), and skin burning sensation (2.6%).ConclusionAbametapir lotion, 0.74%, was effective at clearing active head louse infestations through day 14 in subjects aged 6 months and older. All adverse events (including one serious but unrelated to study drug) resolved uneventfully.
Prevalence of depressive symptoms in elderly cancer patients receiving chemotherapy and influencing factors
Authors: Atag Elif , Mutlay Feyza , Soysal Pinar , Semiz Huseyin S. , Kazaz Seher N. , Keser Murat , Ellidokuz Hulya , Karaoglu Aziz 
Published: July 2018

BackgroundDepression is one of the most prevalent causes of distress in the geriatric population. The purpose of this study was to examine the prevalence of depressive symptoms in elderly cancer patients and to determine the possible associated factors.MethodsCancer patients 65 years or older and on active chemotherapy completed the Yesavage Geriatric Depression Scale. We examined the relationship of depressive symptoms with age, gender, marital status, educational background, type of cancer, stage of disease, comorbidities, types of treatment for cancer, the duration after diagnosis of cancer, social support, and pain status.ResultsThe study included 170 patients with a mean age of 71 years, and 47.1% were women. The prevalence of a high depressive symptom score was 19.4%. Of the patients who had a high depressive symptom score based on the Yesavage Geriatric Depression Scale, 18.2% had already been diagnosed with depression and used antidepressants. The mean pain score was significantly higher in patients who had a high depressive symptom score compared to others (P = 0.012).ConclusionThe prevalence of depressive symptoms in elderly cancer patients receiving chemotherapy was similar to that in the geriatric population without cancer. It was also consistent with previous studies on elderly cancer population. Pain was found to be a factor related to depressive symptoms. The prevalence of depression may be reduced by pain control. The treatment of depression may both improve the patient's quality of life and enhance their compliance with treatment.
Use of models for the environmental risk assessment of veterinary medicines in European aquaculture: current situation and future perspectives
Authors: Rico Andreu , Vighi Marco , Van den Brink Paul J. , ter Horst Mechteld , Macken Ailbhe , Lillicrap Adam , Falconer Lynne , Telfer Trevor C. 
Published: July 2018

AbstractVeterinary Medicinal Products (VMPs) are used in intensive aquaculture production to treat a wide range of bacterial and parasitic infestations. Their release into the environment poses concerns regarding their potential ecotoxicological risks to aquatic ecosystems, which need to be evaluated making use of appropriate Environmental Risk Assessment (ERA) schemes and models. This study presents an overview of the major aquaculture production systems in Europe, the VMPs most commonly used, and the environmental quality standards and regulatory procedures available for their ERA. Furthermore, it describes the state‐of‐the‐art on the development of environmental models capable of assessing the fate, exposure, ecotoxicological effects and risks of VMPs in aquaculture production systems, and discusses their level of development and implementation within European aquaculture. This study shows that the use of environmental models in regulatory ERA is somewhat limited in many European countries. Major efforts have been dedicated to assess the fate and exposure of antiparasitic compounds in salmonid cage systems, particularly in Scotland, while models and scenarios for assessing dispersal of antimicrobials, in general, and antiparasitic compounds in the Mediterranean as well as in Scandinavian regions are less available. On the other hand, the use of ecological models for assessing the effects and risks of VMPs is almost absent. Recommendations are provided to improve the chemical exposure and effect assessments and the ecological realism of the modelling outcomes, paying special attention to the protection goals set for the regulatory ERA of VMPs in Europe.
Birth Planning and Women's and Men's Health in Malawi
Authors: Yeatman Sara , Smith‐Greenaway Emily 
Published: July 2018

AbstractDespite the frequency with which it occurs, we know little about unintended fertility in sub‐Saharan Africa and even less about its implications for the health of the women and men who experience it. We use longitudinal data from southern Malawi to explore how young adults report on the planning of their births and to identify changes in their self‐rated health and subjective well‐being associated with having more‐ or less‐planned births. Our data feature a comprehensive scale of pregnancy planning, the London Measure of Unplanned Pregnancy (LMUP), that extends beyond the conventional focus on timing‐based pregnancy intentions to incorporate information about contraception, desires, intentions, partner discussion, and preconception preparations. Women and men have similar bimodal distributions on the LMUP, with the majority of births clearly unplanned or planned but a sizeable minority that falls in the middle. Change score models demonstrate that, for women, an unplanned birth is associated with a decline in self‐rated health. In contrast, men whose births were ambivalently‐planned experience a decline in subjective well‐being. Our findings highlight the value of considering the full spectrum of birth planning and demonstrate the health consequences of unplanned fertility for both women and men in this sub‐Saharan context.
Evaluating the Feasibility and Effectiveness of an Australian Safety Planning Smartphone Application: A Pilot Study Within a Tertiary Mental Health Service
Authors: Melvin Glenn A. , Gresham Daniel , Beaton Susan , Coles Jan , Tonge Bruce J. , Gordon Michael S. , Stanley Barbara 
Published: July 2018

ObjectiveThe purpose of this study was to examine the feasibility and effectiveness of a suicide prevention smartphone application.MethodThirty‐six non‐Aboriginal Australians aged between 16 and 42 years (67% female) were recruited from a tertiary mental health service where they were receiving treatment for suicide risk. Participants were asked to use the BeyondNow safety planning smartphone application to manage their suicide safety plan during a 2‐month trial, as an adjunct to treatment as usual. A survey battery designed to measure feasibility and effectiveness of the smartphone app plus treatment as usual intervention was completed at baseline and follow‐up.ResultsA vast majority of participants used the app to view and edit their safety plans and reported that the app was easy to use. A reduction was observed in participant severity and intensity of suicide ideation, and suicide‐related coping increased significantly. No significant changes were observed in suicide resilience.ConclusionsThe BeyondNow safety planning smartphone application was shown to be feasible and effective as an adjunct to mental health treatment among patients at risk of suicide.
Football training over 5 years is associated with preserved femoral bone mineral density in men with prostate cancer
Authors: Uth J. , Fristrup B. , Haahr R. D. , Brasso K. , Helge J. W. , Rørth M. , Midtgaard J. , Helge E. W. , Krustrup P. 
Published: July 2018

This study investigated the association between long‐term adherence to football training and retaining bone mineralization and physical capacity in men with prostate cancer (PCa) managed with androgen deprivation therapy (ADT). Patients completing follow‐up at 32 weeks in the FC Prostate Randomized Controlled Trial (RCT) in 2012 or 2013 were invited to 5‐year follow‐up assessments in May 2017 (n = 30). Changes in physiological outcomes over time between the football participants (FTG) and nonparticipants (CON) were examined. Twenty‐two men accepted the invitation of which 11, aged 71.3 ± 3.8 years, had continued to play self‐organized football 1.7 (SD 0.5) times per week for 4½ years (±8 months). At 5 years, right femoral neck bone mineral density (BMD) had improved significantly in the FTG compared to CON (P = .028). No other significant between‐group differences were observed. In FTG, RHR decreased by 4.3 bpm (P = .009) with no changes in CON. Muscle mass, knee‐extensor muscle strength, VO2 max, and postural balance decreased in both groups. In FTG, the fraction of training time with HR between 80%‐90% or >90% of HRmax was 29.9% (SD 20.6) and 22.8% (SD 28.7), respectively. Average distance covered during 3 × 20 minutes of football training was 2524 m (SD 525). Football training over a 5‐year period was associated with preserved femoral neck BMD in elderly men with PCa managed on ADT. Intensity during football training was >80% of HRmax for 51% of training time after 5 years. Body composition and physical capacity deteriorated over 5 years regardless of football participation.
User opinions for the Veterinary Radiology & Ultrasound journal differ among demographic groups
Authors: Jones Jeryl C. , Lascano Johanna J. 
Published: July 2018

AbstractMeeting the changing needs of journal users is important for veterinary editors. The objective of this prospective survey study was to analyze user opinions for the journal Veterinary Radiology & Ultrasound. An online survey was developed based on a consensus among the journal's Editor‐in‐Chief and Editorial Board members, an industrial organizational psychologist, Executive Council members for the journal's owner organization, representatives of the journal's publisher, and members of the authors’ University Institutional Review Board. The online survey link was sent via email to members of the journal's five represented organizations and responses were collected from January 2016 to June 2016. The survey response rate was 38.5% (478 survey responses received/1241 emails sent). Private practitioners were significantly more likely than academicians to consider the reviewer feedback to be accurate (U = 5855, P < 0.05). Respondents from North America were significantly more likely than Europeans to consider the reviewer feedback to be insightful (U = 6212, P < 0.05). A majority of respondents (75.1%) agreed or strongly agreed that the journal should change to a double‐blinded peer review system, which has been implemented. Perceptions of quality and satisfaction with the journal were highly correlated to each other (r = 0.68, P < 0.01) and positively correlated with respondent age. Findings indicated that opinions of Veterinary Radiology & Ultrasound users are diverse and differ among some demographic groups. These results may be used to guide future strategic planning to ensure that journal content and Editorial Board membership are representative of these diverse points of view.
Persistence of Escherichia coli in the soil of an organic mixed crop‐livestock farm that integrates sheep grazing within vegetable fields
Authors: Patterson Laura , Navarro‐Gonzalez Nora , Jay‐Russell Michele T. , Aminabadi Peiman , Antaki‐Zukoski Elizabeth , Pires Alda F. A. 
Published: July 2018

AbstractMixed crop‐livestock farms (MCLF) integrate livestock and crops using their animals to graze crop residues and/or cover crops. MCLF are considered sustainable because grazing and the manure deposited by livestock enhance soil fertility and recycles farm nutrients. However, livestock manure may introduce enteric foodborne pathogens to the soil, which could contaminate fresh produce. Organic farmers in the United States follow the USDA National Organic Program (NOP) standards, which require 90 or 120 days between incorporating raw manure into the soil and harvest. Although not specifically addressed in NOP, organic farmers using grazing within production fields may also use this standard. The objectives of this study were to generate preharvest data to assess the die‐off of generic Escherichia coli (E. coli) in the soil, after cover crops were grazed by sheep; and assess the genetic relatedness of generic E. coli isolates between soil and sheep faecal samples. We conducted a repeated observational study to evaluate the persistence of generic E. coli, as an indicator of faecal contamination and surrogate for STEC, in the soil of two fields (A and B) on an organic MCLF. Results showed a 3.70 log10 reduction in mean generic E. coli concentration MPN in the soil of field A from the highest of 3.70 log10 MPN/g on 48 day postsheep grazing (DPS) to −0.70 log10 MPN/g on 139 DPS. Field B showed a 3.51 log10 reduction in mean generic E. coli concentration in the soil from the highest mean of 3.51 log10 MPN/g on 14 DPS to the lowest mean −0.35 log10 MPN/g on 112 DPS. STEC prevalence in the sheep flock was 4.17% (1/24). Closely related generic E. coli strains were found between soil and faecal samples. Developing research‐based waiting periods between grazing and harvest is important to inform best practices for farmers and food safety regulators.
Recommendations and practices for the screening of depression and anxiety in acute coronary syndrome: a scoping review protocol
Authors: Franzon Julie , Haren Matthew T. , Kourbelis Constance , Marin Tania , Newman Peter , Jones Martin , Muir-Cochrane Eimear , Clark Robyn A. 
Published: July 2018

Objective:
The objective of this scoping review is to identify and map current recommendations and practices for the screening of depression and anxiety in acute coronary syndrome patients in the acute care setting.
Specifically, the review questions are:
The association of overjet with traumatic dental injuries: a systematic review protocol
Authors: Arraj George P. , Rossi-Fedele Giampiero , Doğramacı Esma J. 
Published: July 2018

Review question:
The objective of this review of association (etiology) is to identify the relationship between different overjet measurements and developing a traumatic dental injury (TDI) across different dentition stages. Specifically, the review will elucidate the critical level, in millimetres, at which an overjet will place an individual at an increased risk of developing a TDI within each specific dentition stage. The specific review questions are: