bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tibial Diaphyseal Fracture Rates Following Tibial Tuberosity Advancement Rapid (TTAR) and Traditional Tibial Tuberosity Advancement (tTTA)
Authors: Chong Wye Li 
Published: March 2019

<strong>PICO question</strong><br /><p>In dogs with cruciate disease, is the use of TTA Rapid (TTAR) compared to traditional TTA (tTTA) associated with a higher risk of tibial diaphyseal fractures?</p><strong>Clinical bottom line</strong><br /><p>Based on studies published between January 2013 and January 2018, the rate of tibial diaphyseal fractures as a complication of Tibial Tuberosity Advancement Rapid (TTAR) surgery is within the published limits of traditional Tibial Tuberosity Advancement (tTTA). In this period, seven studies were related to tTTA, comprising of four; one case series, two retrospective case-control studies, and one retrospective cohort study. Five case series were related to TTAR. All evidence within this period has been observational (Level 3 and 4 evidence). No direct head-to-head comparison between the techniques has been studied. </p><br /> <img src="https://www.veterinaryevidence.org/rcvskmod/icons/oa-icon.jpg" alt="Open Access" /> <img src="https://www.veterinaryevidence.org/rcvskmod/icons/pr-icon.jpg" alt="Peer Reviewed" />
PENYALAHGUNAAN KEADAAN (MISBRUIK VAN OMSTANDIGHEDEN) SEBAGAI LARANGAN DALAM PERJANJIAN SYARIAH
Authors: Fidhayanti Dwi 
Published: March 2019

<p>The principle of freedom of contract may cause problems in the form of an indication of misuse of circumstances (misbruik van omstandigheden) in the agreement. Misuse of circumstances (misbruik van omstandigheden) occurs when a person in a covenant is influenced by something that prevents him from making a judgment free from the other so that he can not take an independent decision. This research uses normative research with a legislative approach. invitations and conceptual approaches. Legal material is obtained through literature study and analyzed by legal interpretation method. The results of the study and discussion show that the concept of misuse of state (misbruik van omstandigheden) in the agreement is included in a covenant with a defective will. One party who has a strong position to suppress and even threaten against parties who have a weaker position so Bargaining position is not balanced. Persons who have a weak position are not given the freedom to give their opinion on the contents of the agreement. Sharia treaties that contain elements of abuse of the circumstances (misbruik van omstandigheiden or undue influence) are included in the forbidden agreement, called ikrah. To do slander is to do wrongdoing. As a result of the law, the agreement becomes null and void.</p>Asas kebebasan berkontrak dapat menimbulkan permasalahan berupa adanya indikasi penyalahgunaan keadaan (misbruik van omstandigheden) dalam perjanjian. Penyalahgunaan keadaan (misbruik van omstandigheden) terjadi manakala seseorang di dalam suatu perjanjian dipengaruhi oleh suatu hal yang menghalanginya untuk melakukan penilaian (judgement) yang bebas dari pihak lainnya, sehingga ia tidak dapat mengambil putusan yang independen.Penelitian ini menggunakan penelitian normatif dengan pendekatan perundang-undangan dan pendekatan konseptual. Bahan hukum didapatkan melalui studi pustaka dan dianalisis dengan metode intepretasi hukum. Hasil penelitian dan pembahasan menunjukkan bahwa konsep penyalahgunaan keadaan (misbruik van omstandigheden) dalam perjanjian termasuk dalam perjanjian yang cacat kehendak. Salah satu pihak yang mempunyai posisi kuat untuk menekan bahkan mengancam terhadap pihak yang mempunyai posisi lebih lemah sehingga Bargaining position tidak seimbang. Pihak yang punya posisi lemah tidak diberikan kebebasan untuk memberikan pendapatnya atas isi perjanjian. Perjanjian syariah yang mengandung unsur penyalahgunaan keadaan (misbruik van omstandigheiden atau undue influence) termasuk pada perjanjian yang dilarang, yang disebut dengan ikrah. Berbuat Ikrah berarti berbuat zalim. Akibat hukumnya, yaitu perjanjian tersebut menjadi batal demi hukum.
Implementation of Pre-/Post-Weights to Enhance Direct Breastfeeding in the NICU
Authors: Juliano Gina M. , Puchalski Mary L. , Walsh Susan M. 
Published: March 2019

IntroductionMother's own milk (MOM) is recommended as the optimal nutrition for preterm infants. Direct breastfeeding (DBF) is correlated with a longer duration of receiving MOM during hospitalization. Infants' transition to DBF may be enhanced when accurate pre-/post-weights are incorporated into nursing practice. An evidence-based practice change was introduced to promote use and increase consistency in methodology of pre-/post-weights after DBF in the neonatal intensive care unit (NICU), with the ultimate goal of increasing DBF at hospital discharge.MethodsThe practice change was introduced through an educational program, a video demonstrating pre-/post-DBF weighing techniques, and a return-demonstration. A 10-item pre-/posttest was used to evaluate nurses' knowledge gained by an educational intervention that included seven knowledge questions, three attitude questions, and three demographic descriptors.ResultsNurses' knowledge gained following the educational intervention was statistically significant (p < .001) using a paired t-test.ConclusionsThe use of pre-/post-DBF weights as an accurate assessment of MOM transfer can promote DBF during hospitalization through education of NICU nurses. Understanding nursing characteristics and attitudes can aid in promotion of DBF in the NICU by bedside nurses.
CAN INDONESIA INVOKE PUBLIC MORALS EXCEPTION UNDER THE WORLD TRADE ORGANIZATION (WTO) FOR PROHIBITING CROSS-BORDER GAMBLING?
Authors: Widiatedja I Gusti Ngurah Parikesit 
Published: March 2019

<p>Under the WTO, Indonesia is obliged to liberalize its markets through establishing the schedule that comprise a list of services that can be either opened or closed to foreign suppliers. However, Indonesia’s schedule is vague as to whether gambling services are closed to foreign suppliers. Through this loophole, the practice of cross-border gambling services has been rampant, resulting in some consequences, especially those related to money laundering and underage gambling. Tackling this problem, Indonesia could apply public morals exception that allows member states to impose trade prohibition. By using public morals exception that was applied in some WTO cases, this article explores the way in which Indonesia could justify prohibiting cross-border gambling services. This article claims that Indonesia has a justification to impose public morals exception under the WTO to prohibit cross-border gambling services within its territory because the prohibition would be designed to protect public morals; it would be necessary to protect public morals; and the prohibition would equally apply to both foreign and local suppliers in cross-border gambling services in Indonesia.<strong></strong></p>
Exploring the dualism of vision – visual function and functional vision
Authors: Silveira Susan 
Published: March 2019

Abstract
Professionals working in the field of vision impairment face high expectations from the people they support. To meet this expectation, it is critical that professionals have a broad and in-depth knowledge of vision. This paper presents an overview of the two key entities that underpin an understanding of vision – visual function and functional vision. The contemporary professional literature is reviewed to present an examination of vision as a primary and essential sense, to develop an understanding of the dual components of vision and common approaches to vision assessment, and the key models that conceptualise vision in relation to the person and their environment.
Wastewater treatment and recycle from a semiconductor industry: A demo-plant study
Authors: Eng Chin Yee , Yan Dongning , Withanage Nipuna , Liang Qiyi , Zhou Yan 
Published: March 2019

AbstractThe objective of this study was to establish a demo-scale plant with 1,000 cubic metres per day (CMD) capacity to recycle industrial wastewater from a semiconductor industry. In this study, two wastewater streams from continuous electrodeionization (CEDI) and local scrubber (LS)/controlled decomposition and oxidation (CDO) with flow rate of 1,335 CMD and 1,012 CMD respectively were chosen to be recycled. For the CEDI reject reclaim system, boron selective resin (BSR) and activated carbon filter (ACF) were utilized to remove boron and total organic carbon (TOC) respectively. The water quality was good enough to be used as ultrapure water (UPW) supply. For the CDO reclaim system, the combination of ACF + ultrafiltration (UF) + reverse osmosis (RO) under high pH condition was implemented to recycle the local scrubber wastewater (LSW) for cooling tower top up. Product water from both treatment systems was able to meet the target water specifications. The average cost saving was S$0.91/m3 of reclaimed water produced.
Optimization of cation-doped nano-hydroxyapatite in combination with amorphous aluminum hydroxide for defluoridation
Authors: Gupta Agman , Manohar Chelli Sai , Siva Kumar Belliraj 
Published: March 2019

Abstract
Given widespread fluoride in the ground water, there is a need for effective defluoridation in several geographical areas. In this regard, we explored heavily doped cationic nano-composites of hydroxyapatite (HA) given its surface chemistry for adsorption of the specific anion. We synthesized and extensively characterized HA nano-rods (HA-NR), Al/Mg-HA nanocomposites and amorphous aluminum hydroxide, and optimized their efficient defluoridation. The kinetics and thermodynamics of adsorption were further evaluated to establish the mechanistic rationale and its spontaneity. We report the optimized ideal adsorbents for the near-total removal of fluoride that demonstrated 99.99% and 99.98% efficiency with adsorption capacities of 83.3 and 81.3mg/g respectively. The adsorbent composites were (Mg-HA)-Al(OH)3 and (HA-NR)-Al(OH)3 in 1:1 ratio. The optimal conditions for defluoridation were 25mg of adsorbent in 25ml (10mg/L) fluoride solution at room temperature agitated for 10h in the pH range of 4.88–7.20.
Molecular Dynamics Simulations of Adenosine Receptors: Advances, Applications and Trends
Authors: Al-Shar'i Nizar A. , Al-Balas Qosay A. 
Published: March 2019

:Adenosine receptors (ARs) are transmembrane proteins that belong to the G protein-coupled receptors (GPCRs) superfamily and mediate the biological functions of adenosine. To date, four AR subtypes are known, namely A1, A2A, A2B and A3 that exhibit different signaling pathways, tissue localization, and mechanisms of activation. Moreover, the widespread ARs and their implication in numerous physiological and pathophysiological conditions had made them pivotal therapeutic targets for developing clinically effective agents.:The crystallographic success in identifying the 3D crystal structures of A2A and A1 ARs has dramatically enriched our understanding of their structural and functional properties such as ligand binding and signal transduction. This, in turn, has provided a structural basis for a larger contribution of computational methods, particularly molecular dynamics (MD) simulations, toward further investigation of their molecular properties and designing bioactive ligands with therapeutic potential. MD simulation has been proved to be an invaluable tool in investigating ARs and providing answers to some critical questions. For example, MD has been applied in studying ARs in terms of ligand-receptor interactions, molecular recognition, allosteric modulations, dimerization, and mechanisms of activation, collectively aiding in the design of subtype selective ligands.:In this review, we focused on the advances and different applications of MD simulations utilized to study the structural and functional aspects of ARs that can foster the structure-based design of drug candidates. In addition, relevant literature was briefly discussed which establishes a starting point for future advances in the field of drug discovery to this pivotal group of drug targets.
How Cancer Cells Resist Chemotherapy: Design and Development of Drugs Targeting Protein-Protein Interactions
Authors: Tarasov Vadim V. , Chubarev Vladimir N. , Ashraf Ghulam Md , Dostdar Samira A. , Sokolov Alexander V. , Melnikova Tatiana I. , Sologova Susanna S. , Grigorevskich Ekaterina M. , Makhmutovа Alfiya , Kinzirsky Alexander S. , Klochkov Sergey G. , Aliev Gjumrakch 
Published: March 2019

Background:Resistance toward chemotherapeutics is one of the main obstacles on the way to effective cancer treatment. Personalization of chemotherapy could improve clinical outcome. However, despite preclinical significance, most of the potential markers have failed to reach clinical practice partially due to the inability of numerous studies to estimate the marker’s impact on resistance properly.Objective:The analysis of drug resistance mechanisms to chemotherapy in cancer cells, and the proposal of study design to identify bona fide markers.Methods:A review of relevant papers in the field. A PubMed search with relevant keywords was used to gather the data. An example of a search request: drug resistance AND cancer AND paclitaxel.Results:We have described a number of drug resistance mechanisms to various chemotherapeutics, as well as markers to underlie the phenomenon. We also proposed a model of a rational-designed study, which could be useful in determining the most promising potential biomarkers.Conclusion:Taking into account the most reasonable biomarkers should dramatically improve clinical outcome by choosing the suitable treatment regimens. However, determining the leading biomarkers, as well as validating of the model, is a work for further investigations.
An UPLC-MS/MS Method for Routine Quantification of Insulin Degludec in Plasma
Authors: Zhang Yudong , Jiang Yue , Wang Ya , Wang Ling , Han Weijie , Cheng Xiaoyi , Deng Xue , Qin Chunmeng , Liu Yan 
Published: March 2019

Background:
Chromatographic methods for determination of insulin degludec in rabbit
plasma by Ultra Performance Liquid Chromatography-Tandem Mass Spectrometry were developed.

Methods:
Analytes were eluted from Waters ACQUITY UPLC® Peptide BEH C18 (2.1×50mm, 300Å)
column with a mobile phase of water containing 0.1% formic acid (A) and acetonitrile containing 0.1%
formic acid (B). Quantitation of insulin degludec was performed using 1222.06 > 641.24 m/z on Multiple-
Reaction Monitoring (MRM) mode.

Results:
Good linearity was observed in the concentration range of 500-50000 ng/mL (r >0.99), and the
lower limit of quantification was 500ng/mL. The within-run and between-run precision (expressed as
relative standard deviation, RSD) of insulin degludec were ≤ 14.16% and ≤ 13.64% respectively, and
the accuracy was within 94.37-96.35%. The recovery and matrix effects were both within acceptable
limits.

Conclusion:
This method was successfully applied for the pharmacokinetic study of insulin degludec
in rabbit after subcutaneous administration.
Molecularly Imprinted Electrochemical Sensors: Analytical and Pharmaceutical Applications Based on Ortho-Phenylenediamine Polymerization
Authors: Bozal-Palabiyik Burcin , Erkmen Cem , Uslu Bengi 
Published: March 2019

Background:The molecular imprinting technique has been applied in many fields including separation, artificial antibody mimics, catalysis, sensing studies, and drug delivery. The reasons for the popularity of this technique among the researchers are high selectivity due to the cavities that are formed on the polymer surface for the specific analyte, high robustness, high durability under extreme conditions and low cost. When these advantages are combined with the advantages of electrochemical methods such as rapid response time, ease of use, cheapness and miniaturizability, Molecularly Imprinted Polymer (MIP) based electrochemical sensors turn out to be a widely-preferred sensing tool.Objective:This article provides the reader with information on MIP-based electrochemical sensors and reviews the applications of the MIP sensors prepared by electropolymerization of orthophenylenediamine, a monomer whose mechanical and chemical stability is very high.Results and Conclusion:The literature survey summarized in this review shows that cyclic voltammetry is the most widely preferred electrochemical technique for electropolymerization of o-PD. The media chosen is generally acetate or phosphate buffers with different pH values. Although there are numerous solvents used for template removal, generally methanol and NaOH have been chosen.
Impairment of Quality of Life Associated With Lifetime Diagnosis of Post-traumatic Stress Disorder in Women - A National Survey in Italy
Authors: Sancassiani Federica , Carmassi Claudia , Romano Ferdinando , Balestrieri Matteo , Caraci Filippo , Di Sciascio Guido , Drago Filippo , Faravelli Carlo , Hardoy Maria Carolina , Moro Maria Francesca , Roncone Rita , Preti Antonio , Dell’Osso Liliana 
Published: March 2019

Introduction:
The aim of the study was to measure the lifetime prevalence of Post-Traumatic Stress Disorder (PTSD) among women of an Italian community sample, the comorbidity of PTSD with mood and anxiety disorders and the burden attributable to PTSD in worsening the Quality of Life (QoL).

Methods:
Community survey on a sample of 1961 adult women randomly selected. Tools: psychiatric clinical interview ANTAS partially derived from the SCID-DSM-IV, administered by psychologists or medical doctors; Short Form Health Survey (SF-12); Mood Disorder Questionnaire (MDQ).

Results:
Lifetime prevalence of PTSD in women was 1.3%, (1.4% in<45 years aged, 1.3% in >44 years aged; p=0.8). In order of risk of comorbidity, PTSD was associated with: Bipolar Spectrum Disorders (MDQ+), Panic Disorders (PD) and Major Depressive Disorder (MDD). People with PTSD showed an SF-12 mean score lower than women of the same sample without PTSD (standardized by gender and age), with a mean difference (attributable burden) of 3.9±0.9 similarly to MDD and Eating Disorders and higher than PD. Among the analyzed nonpsychiatric diseases, Multiple Sclerosis and Carotid Atherosclerosis showed a higher burden in impairing QoL than PTSD; Wilson’s Disease showed a similar burden and Celiac Disease was found less impairing on QoL than PTSD.

Conclusion:
The attributable burden in worsening women’ perceived QoL due to a lifetime diagnosis of PTSD was found comparable to those caused by MDD, Eating Disorders or by neurological condition such as Wilson’s Disease. The comorbidity of PTSD with Bipolar Spectrum Disorders was remarkable, even further studies are needed to clarify the direction of causality.
Optimization of PV Based Standalone Hybrid Energy System using Cuckoo Search Algorithm
Authors: Tikkiwal Vinay Anand , Singh Sajai Vir , Gupta Hariom 
Published: March 2019

Background:
Renewable sources of energy have emerged as a promising eco-friendly alternative
to the conventional and non-renewable sources of energy. However, highly variable and
intermittent nature of renewable sources acts as a big hurdle in their widespread adoption. Hybrid
energy systems provide an efficient and reliable solution to this issue, especially for the non-grid
connected or stand-alone systems.

Objective:
The study deals with the design and optimization of a stand-alone hybrid renewable energy
system.

Methods:
Two different configurations consisting of PV/W/B/DG have been modeled and optimized
for lower annualized cost using cuckoo search, a meta-heuristic algorithm. Analysis of these system
configurations has been carried to meet the energy demand at the least annualized cost.

Results and Conclusion:
Using a real world data for an existing educational organization in India, it
is proven that the proposed optimization method meets all the requirements of the system and
PV/B/DG configuration returns a lower annualized cost as well as leads to lower emissions.
Weekly Standard Kt/Vurea and Clinical Outcomes in Home and In-Center Hemodialysis
Authors: Rivara Matthew B. , Ravel Vanessa , Streja Elani , Obi Yoshitsugu , Soohoo Melissa , Cheung Alfred K. , Himmelfarb Jonathan , Kalantar-Zadeh Kamyar , Mehrotra Rajnish 
Published: March 2019

Background and objectives
Patients undergoing hemodialysis with a frequency other than thrice weekly are not included in current clinical performance metrics for dialysis adequacy. The weekly standard Kt/Vurea incorporates treatment frequency, but there are limited data on its association with clinical outcomes.

Design, setting, participants, & measurements
We used multivariable regression to examine the association of dialysis standard Kt/Vurea with BP and metabolic control (serum potassium, calcium, bicarbonate, and phosphorus) in patients incidental to dialysis treated with home (n=2373) or in-center hemodialysis (n=109,273). We further used Cox survival models to examine the association of dialysis standard Kt/Vurea with mortality, hospitalization, and among patients on home hemodialysis, transfer to in-center hemodialysis.

Results
After adjustment for potential confounders, patients with dialysis standard Kt/Vurea <2.1 had higher BPs compared with patients with standard Kt/Vurea 2.1 to <2.3 (3.4 mm Hg higher [P<0.001] for home hemodialysis and 0.9 mm Hg higher [P<0.001] for in-center hemodialysis). There were no clinically meaningful associations between dialysis standard Kt/Vurea and markers of metabolic control, irrespective of dialysis modality. There was no association between dialysis standard Kt/Vurea and risk for mortality, hospitalization, or transfer to in-center hemodialysis among patients undergoing home hemodialysis. Among patients on in-center hemodialysis, dialysis standard Kt/Vurea <2.1 was associated with higher risk (adjusted hazard ratio, 1.11; 95% confidence interval, 1.07 to 1.14) and standard Kt/Vurea ≥2.3 was associated with lower risk (adjusted hazard ratio, 0.97; 95% confidence interval, 0.94 to 0.99) for death compared with standard Kt/Vurea 2.1 to <2.3. Additional analyses limited to patients with available data on residual kidney function showed similar relationships of dialysis and total (dialysis plus kidney) standard Kt/Vurea with outcomes.

Conclusions
Current targets for standard Kt/Vurea have limited utility in identifying individuals at increased risk for adverse clinical outcomes for those undergoing home hemodialysis but may enhance risk stratification for in-center hemodialysis.