bluuebunny/crossref_metadata_2025_split huggingface dataset:
Construct Validity of the Orientation to Life Questionnaire in a General Adult Population in Norway and Its Association with Self‐Reported General and Oral Health
Authors: Mathisen Kine Margrethe , Johnsen Jan‐Are Kolset , Holde Gro Eirin , Jönsson Birgitta 
Published: November 2024

ABSTRACTObjectiveIndividuals' Sense of Coherence (SOC) is measured with the Orientation to Life Questionnaire (OLQ‐13). SOC reflects a person's orientation to life and ability to manage stress, which can impact health. The aim of the study was to test the reliability and construct validity of the OLQ‐13, with self‐reported general and oral health as criterion measures, in a Norwegian general adult population.MethodsData were collected using the OLQ‐13 in addition to items measuring sociodemographic information, self‐reported general health and self‐reported oral health. This study was based on data from a population‐based cross‐sectional oral health study in Troms County, conducted from October 2013 to November 2014 (n = 1875, mean age 47.4 years, 50.5% women). Internal consistency was examined with Cronbach's alpha (α). Confirmatory factor analysis (CFA) was used to test the construct validity (one‐ and three‐factor structure of the OLQ‐13). The associations between SOC and self‐reported general and oral health were tested using one‐way ANOVA.ResultsThe internal consistency of the OLQ‐13 was good (α = 0.84). The CFA showed that while the OLQ‐13 demonstrated an unacceptable fit, a shortened 11‐item version with a three‐factor structure revealed an acceptable fit and good internal consistency (α = 0.86). The highest mean SOC scores were found among individuals reporting good or very good general and oral health.ConclusionA three‐factor structure with an 11‐item version of the OLQ to assess SOC showed better validity than OLQ‐13 in a general population in Northern Norway. Self‐reported general and oral health can be considered appropriate criterion measures when validating SOC. To achieve a valid measurement scale for assessing SOC, a revision of the OLQ‐13 appears necessary, and further studies are needed.
Dental Hygienists' Readiness to Perform Resin Infiltrations: A Qualitative Study From Finland
Authors: Kerälä Susanna , Laurila Katriina , Kajula Outi , Keinänen Anna‐Leena 
Published: November 2024

ABSTRACTObjectivesResin infiltration is a micro‐invasive treatment method for non‐cavitated enamel lesions that aims to arrest the progression of carious lesions and improve the aesthetic qualities of teeth. The aim of this study is to provide a description of dental hygienists' readiness to perform resin infiltration and their experiences of performing it.MethodsThe study was conducted during the years 2020 and 2021 using qualitative research methods. The data was collected through semi‐structured single interviews and analysed using inductive content analysis. The informants were dental hygienists (n = 10) from Finland. The criterion for participation was experience of performing resin infiltration. The average number of procedures performed was seven. Five out of 10 informants had received training in the technique prior to their first procedure.ResultsDental hygienists had varied experiences of resin infiltrations. The readiness required to perform resin infiltrations was seen to be equivalent to their basic professional skills. Assessing the treatability and extent of lesions caused uncertainty, though readiness was felt to improve with experience. Resin infiltration training and inclusion in the curriculum of a dental hygienist was perceived to be important. The treatment was felt to be well suited to the job description of dental hygienists.ConclusionsThe results indicate that dental hygienists in Finland have adequate readiness to perform resin infiltration. However, the results are based on 10 informants' experiences and therefore cannot be generalised. Including resin infiltration in a dental hygienist's training programme could enhance dental hygienists' readiness to perform resin infiltrations.
One Acne™: A holistic management approach to improve overall skin quality and treatment outcomes in acne with or without sensitive skin
Authors: Kircik Leon , Tan Jerry , Lain Edward (Ted) , Beleznay Katie , Chavda Rajeev , Lachmann Nadège , Brinkhuizen Tjinta , Baldwin Hilary , Layton Alison M. 
Published: November 2024

AbstractAcne and sensitive skin can take a profound toll on patients' well‐being, which can be exacerbated if the conditions are experienced together. This narrative review aims to identify appropriate treatments to facilitate a holistic management approach to acne (One Acne™), sensitive skin, and acne‐induced sequelae and describe the role of treatments in improving skin quality. Topical retinoids are considered the preferred first‐line option for acne treatment by dermatologists, either as monotherapy or in combination with other treatments, because of their ability to target various aspects of the disease. Tretinoin, trifarotene, adapalene, and tazarotene have all been assessed in clinical studies for managing acne‐associated scarring, with varying success, with the latter three reported to improve skin quality. Moreover, some corrective procedures, e.g., injectable non‐animal stabilized hyaluronic acid (NASHA) fillers, have proven effective for treating acne scarring. Both treatment types may complement each other to provide optimal treatment outcomes and patient satisfaction, as observed in several patients receiving concomitant treatment with NASHA fillers/topical trifarotene. Adjunctive use of cleansers, moisturizers, and photoprotection‐containing ingredients such as vitamin B3, glycerin, or pro‐vitamin B3 may also complement drug/corrective treatments to reduce skin irritation and risk of scarring, as well as improve skin hydration, tone, and overall appearance. This narrative review highlights that comprehensive skincare regimens should be used throughout acne patients' journeys to reduce treatment‐related irritation, improve treatment outcomes, adherence, and satisfaction, and enhance overall skin quality. Patients with sensitive skin should choose tailored skincare products to maintain skin barrier integrity and restore skin function.
Real‐world impact of pembrolizumab availability for deficient mismatch repair metastatic colorectal cancer
Authors: Loft Matthew , Wong Vanessa , Kosmider Suzanne , Wong Rachel , Shapiro Jeremy , Hong Wei , Jennens Ross , Tie Jeanne , Caird Susan , Steel Simone , Lee Belinda , Nott Louise , Khattak Muhammad Adnan , Lim Stephanie , Chong Geoffrey , Hayes Theresa , Underhill Craig , McLachlan Sue‐Anne , Rainey Natalie , Dunn Catherine , Gibbs Peter 
Published: November 2024

AbstractBackgroundImmunotherapy has emerged as a standard treatment for deficient mismatch repair (dMMR) metastatic colorectal cancer (mCRC). Pembrolizumab became widely available as a first‐line (1L) option in Australia following the Pharmaceutical Benefits Scheme (PBS) listing in August 2021. The uptake of new treatment options can be lengthy.MethodsThe Treatment of Recurrent and Advanced Colorectal Cancer mCRC registry data at participating Australian sites was analysed from January 2015 (when MMR testing became routine). 1L treatment of dMMR cancers was compared with pre‐ and post‐PBS funding.ResultsOut of 2819 patients, 2344 (83%) had known MMR status. Of these, 162 (7%) were dMMR, which was associated with older age (median age 69 vs 63 years, P = 0.001), a right‐side primary (68% vs 31%, P < 0.001) and a BRAF V600E mutation (49% vs 11%, P < 0.001). Prior to August 2021, 85 out of 117 (73%) patients with dMMR received 1L treatment: 63 out of 85 (74%) chemotherapy and 20 out of 85 (24%) immunotherapy. Following approval, 39 out of 45 (87%) received 1L treatment and 39 out of 39 (100%) pembrolizumab. Of the patients 75 years and older, a significantly higher proportion of patients were treated with any 1L therapy post‐PBS listing (89% vs 60%, P = 0.036).ConclusionPreviously reported associations of dMMR were observed. The higher‐than‐expected proportion of patients with dMMR is likely driven by the inclusion of older patients in this real‐world study. Many patients were able to access immunotherapy prior to PBS listing, potentially through trials or access programs. Early uptake of pembrolizumab following PBS listing has been high, and this effective and well‐tolerated option has increased the proportion of elderly patients receiving active therapy.
Using FRAME Documentation to Achieve RE‐AIM Goals During Iterative, Stakeholder‐Engaged Refinement of a Family Management Intervention for Parents of Preterm Infants
Authors: Weber Ashley M. , Bakas Tamilyn , Bailey Richard , Oudat Qutaibah , Voos Kristin C. , Rice Jared B. , Parikh Nehal A. , Tubbs‐Cooley Heather L. , Lambert Josh , Rota Matthew J. , Kaplan Heather C. 
Published: November 2024

ABSTRACTAimsTo co‐identify adaptations with key stakeholders needed to optimise elements of a video‐based intervention (i.e., PREEMIE PROGRESS [PP]), which trains parents in evidence‐based family management skills to care for their very preterm infant in the neonatal intensive care unit (NICU).DesignDescriptive qualitative study oriented with a pragmatic philosophy, informed by the reach, effectiveness, adoption, implementation, maintenance (RE‐AIM) framework and the framework for reporting adaptations and modifications‐expanded (FRAME).MethodsSemistructured interviews to identify potential adaptations with key stakeholders: family management researchers (n = 5), clinicians (n = 9), technology experts (n = 5) and parents of preterm infants (n = 17). Weekly design team meetings to select and implement high‐priority adaptations necessary for the next research phase. Monthly NICU parent partnership meetings to review adaptations and make recommendations for potential adaptations with conflicting data.ResultsStakeholders (N = 36) suggested 98 potential adaptations: 32 (33.0%) were completed, 8 (8.2%) were abandoned, 5 (5.2%) have work that is ongoing and 52 (53.6%) were tabled for future research phases. Content adaptations (70, 71.4%) were the most frequently suggested adaptation type. Potential adaptations mostly addressed RE‐AIM dimensions of effectiveness (43, 43.9%), and implementation (46, 46.9%) and were directed at the parent (i.e., intervention recipient) level (79, 81.4%).ConclusionUse of the RE‐AIM framework ensured we systematically identified needed adaptations with key stakeholders across a range of dimensions that would improve PP for parents now and in future phases of this research.Implications for the ProfessionCo‐identifying potential adaptations with key stakeholders, paired with FRAME documentation, can help nurses prioritise adaptations most appropriate for each phase of implementation.ImpactOur paper highlights for nurse clinicians and researchers how FRAME documentation of potential adaptations can support stakeholder engagement and a systematic approach to incorporating adaptations throughout all phases of the research process, thereby shortening the evidence to practice gap.Reporting MethodCOREQ guidelines for qualitative reporting.Patient/Public ContributionThe research team was supported by members of the NICU's Parent Partnership Council (PPC), whose mission is to promote family‐centred care improvement projects and research within the NICU. This committee is comprised of nursing, physician, allied health leadership and parents of infants previously hospitalised in the NICU. The NICU PPC met monthly to review conflicting data on potential adaptations and provide recommendations on adaptation decisions.
Selecting Transfemoral Access or Upper Extremity Access for Renal Denervation Based on Vascular Morphology: Long‐term Results
Authors: Zuo Yujie , Dong Hui , Li Hongwu , Ma Wentao , Zou Yubao , Jiang Xiongjing 
Published: November 2024

ABSTRACTTo evaluate the long‐term efficacy and safety of transfemoral access (TFA) versus upper extremity access (UEA) for renal denervation (RDN) based on vascular morphology. This study retrospectively enrolled patients with resistant hypertension who underwent RDN treatment via TFA and UEA (brachial, radial, and ulnar artery) at the Fuwai Hospital between February 2012 and November 2019. Follow‐up was conducted at 6 months, 1 year, and 3 years after RDN, and the last visit was June 2023. A total of 85 patients were enrolled, 58 (68.2%) of them were treated via TFA, and 27 patients (31.8%) via UEA. The fluoroscopy time was less in the TFA group (12.2 ± 5.7 min vs. 15.2 ± 7.2 min; p = 0.038). The procedure time (TFA group: 40.8 ± 14.9 min vs. UEA group: 38.6 ± 11.6 min; p = 0.506), contrast volume (TFA group: 78.2 ± 25.9 mL vs. UEA group: 91.9 ± 39.7 mL; p = 0.061) were similar between two groups, without procedure‐related complications. Fifty‐eight participants completed the last visit with a 3–12 year of follow‐up (9.5 ± 1.3 years). Compared with baseline, there were no significant differences in the change of office systolic blood pressure (−12.6 ± 21.6 mmHg vs. −13.1 ± 22.8 mmHg; p = 0.933), 24‐h mean systolic blood pressure (−11.9 ± 14.2 mmHg vs. −11.3 ± 15.3 mmHg; p = 0.899), the number of antihypertensive drugs, and renal function between two groups. There were three adverse events in the TFA group (3 of 58 patients, 5.2%) versus one (1 of 27 patients, 3.7%) in the UEA group, without a significant difference between the two groups. The study showed RDN via UEA was feasible using a special‐designed catheter, particularly in patients with illegal vascular morphology via TFA.
A special focus on polyadenylation and alternative polyadenylation in neurodegenerative diseases: A systematic review
Authors: Yeganeh Markid Tarlan , Pourahmadiyan Azam , Hamzeh Soroosh , Sharifi‐Bonab Mirmohsen , Asadi Mohamad Reza , Jalaiei Abbas , Rezazadeh Maryam , Ghafouri‐Fard Soudeh 
Published: November 2024

AbstractNeurodegenerative diseases (NDDs) are one of the prevailing conditions characterized by progressive neuronal loss. Polyadenylation (PA) and alternative polyadenylation (APA) are the two main post‐transcriptional events that regulate neuronal gene expression and protein production. This systematic review analyzed the available literature on the role of PA and APA in NDDs, with an emphasis on their contributions to disease development. A comprehensive literature search was performed using the PubMed, Scopus, Cochrane, Google Scholar, Embase, Web of Science, and ProQuest databases. The search strategy was developed based on the framework introduced by Arksey and O'Malley and supplemented by the inclusion and exclusion criteria. The study selection was performed by two independent reviewers. Extraction and data organization were performed in accordance with the predefined variables. Subsequently, quantitative and qualitative analyses were performed. Forty‐seven studies were included, related to a variety of NDDs, namely Alzheimer's disease, Parkinson's disease, Huntington's disease, and amyotrophic lateral sclerosis. Disease induction was performed using different models, including human tissues, animal models, and cultured cells. Most investigations were related to PA, although some were related to APA or both. Amyloid precursor protein (APP), Tau, SNCA, and STMN2 were the major genes identified; most of the altered PA patterns were related to mRNA stability and translation efficiency. This review particularly underscores the key roles of PA and APA in the pathogenesis of NDDs through their mechanisms that contribute to gene expression dysregulation, protein aggregation, and neuronal dysfunction. Insights into these mechanisms may lead to new therapeutic strategies focused on the modulation of PA and APA activities. Further research is required to investigate the translational potential of targeting these pathways for NDD treatment.image
Sacroiliac joint auricular surface morphology modulates its mechanical environment
Authors: Henyš Petr , Hammer Niels 
Published: November 2024

AbstractThe sacroiliac joint (SIJ) exhibits significant variation in auricular surface morphology. This variation influences the mechanics of the SIJ, a central node for transmitting mechanical energy from upper body to lower limbs and vice versa. The impact of the auricular surface morphology on stress and deformation in the SIJ remains poorly understood to date. Computed tomography scans obtained from 281 individuals were included to extract the geometry of the pelvic ring. Then, the auricular surface area, SIJ cartilage thickness, and total SIJ cartilage volume were identified. Based on these reconstructions, 281 finite element models were created to simulate SIJ mechanical loading. It was found that SIJ cartilage thickness only weakly depended on age or laterality, while being strongly sex sensitive. Auricular surface area and SIJ cartilage volume depended weakly and non‐linearly on age, peaking around menopause in females, but without significant laterality effect. Larger SIJs, characterized by greater auricular area and cartilage volume, exhibited reduced stress and deformation under loading. These findings highlight the significant role of SIJ morphology in its biomechanical response, suggesting a potential link between morphological variations and the risk of SIJ dysfunction. Understanding this relationship could improve diagnosis and targeted treatment strategies for SIJ‐related conditions.
The Therapeutic Mechanisms of Huayu Quban Capsule in Treating Acne Vulgaris Are Uncovered Through Network Pharmacology and Molecular Docking
Authors: Zhang Lei , Huang Yu , Zhu Wei 
Published: November 2024

ABSTRACTPurposeTo uncover how the Huayu Quban (HYQB) capsule treats acne vulgaris (AV) through the use of network pharmacology and molecular docking technology.MethodsThe traditional Chinese medicine system pharmacology database (TCMSP) was used to identify the components and potential targets of HYQB capsule. Targets related to AV were identified by screening the GeneCards, Disease Gene Network (DisGeNET) and Online Mendelian Inheritance in Man (OMIM) databases. The protein–protein interaction (PPI) network between targets of active ingredients and AV targets was built using the STRING database. Cytoscape3.7.2 software was used to create the visualization network for the ‘herb‐component‐target’ and identify the key targets. Gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) were utilized for functional enrichment analysis of the primary targets. Subsequently, molecular docking technology was employed to confirm the interaction between key components and core targets.ResultsThe technique discovered 50 different active substances and 270 associated therapeutic targets in the HYQB capsule as well as predicting 70 targets for treating acne vulgaris. Cytoscape hubba plug‐in identified 19 key target genes, with the top 5 being TNF, IL1B, CCL2, SIRT1, IFNG, and IL10. Analysis of KEGG pathways revealed significant enrichment of immune‐related pathways, including TNF and IL‐17 signaling pathways, among the target genes. The HYQB capsule also involves lipid and atherosclerosis, Th17 cell differentiation, and the AGE‐RAGE signaling pathway in diabetic complication signaling pathways. Molecular docking results showed that quercetin, luteolin, kaempferol, and wogonin, the core components of HYQB, had good binding ability with the first 4 core targets.ConclusionsThe HYQB capsule may have a synergistic effect on inhibiting sebaceous adipogenesis and sebum cell differentiation and play an effect on AV through anti‐inflammatory and antioxidant effects of different signaling pathways.
A Prospective and Comparative Study to Explore the Effects of Platelet‐Rich Plasma in Hair Transplantation for Patients With Androgenetic Alopecia
Authors: Xue Ping , Guo Lei , Dang E. , Dou Wenjie , Zeng Xianhui , Fan Xing , Yang Qing 
Published: November 2024

ABSTRACTBackgroundAndrogenetic alopecia (AGA) is the most prevalent type of hair loss. Traditionally, treatment for AGA has primarily involved the topical application of minoxidil in conjunction with oral finasteride or spironolactone. Recently, platelet‐rich plasma (PRP) has emerged as a significant focus of research in hair loss treatment. However, many studies on PRP‐assisted hair transplantation have encountered various limitations.ObjectiveThis study aims to conduct a prospective, comparative clinical investigation to evaluate the therapeutic effects of combining PRP with minoxidil and finasteride/spironolactone as adjuncts to hair transplantation.MethodFrom August 2019 to December 2022, we enrolled 30 patients with AGA in the study, randomly assigning them to an experimental group and a control group. The experimental group received drug therapy alongside hair transplantation and underwent PRP injections, whereas the control group received only drug therapy to assist with hair transplantation.ResultsPrior to surgery, no significant differences in baseline data were observed between the two groups. Following treatment, the experimental group demonstrated significantly improved follicle survival rates, follicle growth rates, and hair strength compared with the control group.ConclusionThis prospective, comparative clinical study demonstrated that the application of PRP in conjunction with pharmacological support during FUE treatment for AGA resulted in improved follicle survival rates, hair growth rates, and hair strength.
A Retrospective Pragmatic Two‐Center Clinical Study to Evaluate the Clinical Outcome of Triple‐Frequency Ultrasound in the Treatment of Mild‐to‐Severe Acne Vulgaris
Authors: Chervinskaya Irina G. , Gaidash Nataliia V. , Kruglikov Ilja L. 
Published: November 2024

ABSTRACTObjectivesEarlier, quickly alternating dual‐frequency ultrasound waves (LDM technology) were successfully applied for the treatment of different inflammatory skin conditions such as rosacea and acne. In this retrospective pragmatic two‐center clinical study, we applied the triple‐frequency LDM (TF‐LDM) technology with frequencies of 1/3/10 and 3/10/19 MHz for the treatment of mild‐to‐severe acne skin to assess the effectivity and sustainability of the treatment outcomes.MethodsTwenty‐two patients with mild‐to‐severe acne were included in this study: 11 patients were treated with TF‐LDM (1/3/10 MHz), and other 11 patients—with TF‐LDM (3/10/19 MHz). Assessment of the acne severity was done using the bilateral facial photographs. The photos were evaluated at baseline (T1), on the day of the last treatment (T2), and during the follow‐up controls (T3). Assessment of the acne severity was provided in accordance with a modified Global Evaluation Acne (mGEA) scale by nine independent dermatologists who were blinded to treatment assignments.ResultsThe average improvement of the mGEA scoring between T1 and T2 across all patients was 73.69% ± 13.90% (p < 0.01), whereas the skin improvement between T1 and T3 was 90.14% ± 8.35% (p < 0.01). The state of the skin was also statistically significantly improved between T2 and T3 (53.26% ± 29.24%, p < 0.02). There was no difference in treatment outcomes between the patients treated with TF‐LDM (1/3/10 MHz) and TF‐LDM (3/10/19 MHz).ConclusionsTF‐LDM is an effective method for the treatment of the mild‐to‐severe acne skin that provides a significant skin improvement and long‐lasting treatment results. The method demonstrates no significant side effects, is pain‐free, well tolerated, and highly accepted by patients.