bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical Results of Intraductal Meibomian Gland Probing Combined with Intense Pulsed Light in Treating Patients with Refractory Obstructive Meibomian Gland Dysfunction: A Randomized Controlled Trial
Authors: Huang Xiaodan , Qin Qiyu , Wang Linping , Zheng Jiao , Lin Lin , Jin Xiuming 
Published: July 2019

Abstract
Background: This study aims to optimize the therapeutic regimen for refractory obstructive meibomian gland dysfunction (o-MGD) patients by combining intraductal meibomian gland probing (MGP) and intense pulsed light (IPL) to enhance their positive effects and reduce their limitations.
Methods: This randomized, assessor blind study includes 45 patients (90 eyes) with refractory o-MGD who were divided into 3 groups via allocation concealment: IPL (group I, received an IPL treatment course: 3 times at 3-week intervals), MGP (group II, received MGP one time), and combined MGP-IPL (group III, MGP first followed by an IPL treatment course). Standard Patient Evaluation of Eye Dryness score (SPEED), tear break-up time (TBUT), corneal fluorescein staining (CFS), meibum grade, and lid margin finding results were assessed at baseline, 3 weeks after final treatment for groups I and III, 3 and 12 weeks after MGP for group II. Six months after final treatment, the SPEED and willingness to receive any treatment again were also collected for all groups. Paired Wilcoxon, Mann-Whitney U with Bonferroni correction, and Kruskal-Wallis tests were used for data analysis.
Results: For all 3 groups, all previously mentioned indexes improved significantly following treatment (P＜0.01). MGP-IPL was better than IPL and MGP in terms of post-treatment SPEED, TBUT, meibum grade, and lid telangiectasia (P＜0.05/3). Furthermore, the MGP-IPL was better than IPL in terms of lid tenderness and better than MGP in terms of orifice abnormality (P＜ 0.05/3). Six months later, the SPEED for the MGP-IPL was also significantly lower than other groups (P＜0.05/3). Moreover, no patients in the MGP-IPL group expressed the need to be treated again compared to 35.7% or 20% of patients in the IPL or MGP groups, respectively.
Conclusions: Compared with IPL or MGP alone, the combination MGP-IPL produced best results in relieving all signs and symptoms and helping patients attain long-lasting symptom relief.
Trial registration: http://clinicaltrials.gov, ChiCTR1900021273 (retrospectively registered February 9, 2019).
Funding: This work was supported by the National Natural Science Foundation of China: [grant numbers: 81870624; 81700802] and the Major Science and Technology Projects of Zhejiang Province [grant numbers: 2017C03046].
Estimating the annual risk of infection with Mycobacterium tuberculosis among adolescents in Western Kenya in preparation for TB vaccine trials
Authors: Nduba Videlis , Hoog Anna H. van’t , de Bruijn Annefleur , Mitchell Ellen M.H. , Laserson Kayla , Borgdorff Martien 
Published: July 2019

Abstract
Background: Adolescents are a prime target group for tuberculosis (TB) vaccine trials that include prevention of infection (POI). The BCG vaccine is given at birth and does not prevent TB infection. TB infection, a critical endpoint for POI vaccine trials would need to be documented to estimate sample sizes in target populations.
Methods: Adolescents aged 12-18 years of age were enrolled in an area under continuous demographic surveillance. A tuberculin skin test (TST) survey was conducted as part of a study on TB prevalence and incidence. All adolescents got TSTs at enrolment and returned after 72 hours for reading. A TST of ≥10mm if HIV negative or ≥ 5mm if HIV positive, was considered positive.
Results: Of 4808 adolescents returning for TST readings (96% of those enrolled), mean age was 14.4 (SD 1.9), 4518(94%) were enrolled in school and 21(0.4%) gave a previous history of tuberculosis. Among adolescents with TST reactivity, the mean TST induration was 13.2 mm (SD 5.4). The overall prevalence of latent TB infection was 1544/4808 (32.1%, 95% CI 29.2-35.1) with a corresponding annual risk of TB infection (ARTI) of 2.6% (95% CI 2.2-3.1). Risk factors for a positive TST included being male (OR 1.3, 95%CI 1.2,1.5), history of having a household TB contact (OR 1.5, 95%CI 1.2,1.8), having a BCG scar (OR 1.5,95%CI 1.2,1.8), living in a rural area (OR 1.4, 95%CI 1.1,1.9), and being out of school (OR 1.8, 95%CI 1.4,2.3).
Conclusion: We conclude that the high TB transmission rates we found in this study, suggest that adolescents in this region may be an appropriate target group for TB vaccine trials including TB vaccine trials aiming to prevent infection.
RATIONAL USE OF THE SECONDARY RESOURCES OF THE VINEYARD AND WINEBRANDING INDUSTRY
Authors: Oganesyants L. A. , Panasyuk A. L. , Kuzmina E. I. 
Published: July 2019

In the grape processing, secondary resources are primarily the remnants of the generative plant organs (berries) — sweet and fermented husks of grapes, seeds, peels, etc. However, the use of vegetative organs — vines, which are more promising, of grape leaves is promising. It is shown, that red leaves of grape are a source of phenolic compounds, resveratrol and other antioxidants, and also contain activators of enzymes, that cause venotonic and angioprotective properties. The most valuable in this respect are red grape leaves, which grow in covering areas, because on the eve of winter, as a defense against the cold, they accumulate a greater amount of resveratrol. The use of CO2 -extraction technology in the processing of red leaves makes it possible to obtain extraction cake with a high content of biologically active substances due to the destruction of the cell structure during the extraction process. At the same time, the hydrophilic extract of the extraction cake after CO2 -extraction has the greatest value, it is well soluble in water and is intended to enrich the soft juice based on grape juice with biologically active substances. A technology was developed for using CO2 extracts of grape seeds to stabilize margarine emulsions against oxidation and to increase the thermal stability of frying fats.
Photocatalytic degradation of Irgalite violet dye using nickel ferrite nanoparticles
Authors: Vijay Shiljashree , Balakrishnan Raj Mohan , Rene Eldon R. , Priyanka Uddandarao 
Published: July 2019

Abstract
Nanotechnologies have prominent applications in the field of science and technology owing to their size-tunable properties providing a promising approach for degradation of various pollutants. In this scenario, the present work aims to study the effect of nickel ferrite nanoparticles on the degradation of Irgalite violet dye by Fenton's reaction using oxalic acid as an oxidizing agent in the presence of sunlight. The effect of pH and adsorbent dosage on the rate of dye degradation was monitored. Based on these studies it was observed that 99% dye degradation was achieved for catalyst dosage of 0.2 g, 400 ppm dye concentration and 2.0 mM oxalic acid at pH 3.0 within 60 min. The studies reveal that the degradation follows pseudo-first-order kinetics and the catalyst reusability remained constant almost for five cycles. Further, nickel ferrite nanoparticles are proven to be an efficient alternative for the removal of dyes from coloured solutions.
Study of impact of acids and comparison of adsorption efficiency of Pb(II) from carbon and its modified nano-nickel coated version
Authors: Asim Tayyaba , Ahmed Riaz , Ansari Muhammad Shahid 
Published: July 2019

Abstract
Acidic content in wastewaters poses greater difficulty in lead removal from most adsorbents as their removal efficiency significantly decreases in acidic media. Nano-nickel coated carbon (Ni/C), compared with uncoated carbon (C), has shown a much enhanced (almost 80% higher) tendency of Pb(II) removal from solutions having different acid concentrations. All of the characterization results show the creation of more active sites and functional groups on Ni/C. The pertinent kinetic models and thermodynamics of Pb(II) adsorption have demonstrated much improved efficiency by Ni/C. Various isotherms subjected to the sorption data revealed significant increase in the sorption capacities for Ni/C. The adsorption (evidently chemisorption) kinetics are best represented by a pseudo-second-order equation. The adsorption rates in acidic solutions were much higher for Ni/C. The temperature-dependent study enabled thermodynamic parameters to be worked out for C and Ni/C; for C the values are ΔH: 19.4 ± 0.5 kJ·mol−1, ΔS: 76.1 ± 2.1 J·mol−1·K−1, ΔG298: −0.37 ± 0.01 kJ·mol−1 while for Ni/C the values are ΔH: 30 ± 1 kJ·mol−1, ΔS: 114 ± 4 J·mol−1·K−1, ΔG298: −4.56 ± 0.02 kJ·mol−1. Both cases indicate endothermic, spontaneous and entropy-driven processes.
The cartel party, consensus democracy and democracy without politics
Authors: Katz Richard S. 
Published: July 2019

Although the age of the mass party as an organizational form is long in the past, the mass party remains a widely accepted normative ideal, closely connected to the idea of party government and to a voters-as-principals-parties-as-agents understanding of democracy. In evolving from mass party, to catch-all party, to cartel party European democracies have also been evolving towards an ‘anti-political’ view of government, along with models of consensus democracy and the regulatory state. This evolution helps to explain the decline in popular connection to political parties. Ironically, the associated causes of this decline are generally regarded as good, notwithstanding that the decline itself is often identified as a crisis. Moreover, analysis of this decline suggests as striking similarity between the consensus model of democracy and the cartel party model of democracy, notwithstanding that the first is often seen as a goal to which democracies should be moving while the second is seen as a threat to democracy itself.
Ressignificação da existência e do cotidiano de pessoas que vivem com HIV .
Authors: Gomes Marcia Pereira , Souza Fabiana Barbosa Assumpção de , Gomes Antônio Marcos Tosoli , Silva Girlene Alves da , Barbosa Diogo Jacintho , Silva André Luis Brugger e 
Published: July 2019

Estudo descritivo, qualitativo, parte de um estudo que analisou as condições de vida pessoas vivendo com HIV (PVHIV) e suas implicações para a qualidade de vida. Objetivo descrever e analisar como os sujeitos ressignificam o cotidiano buscando a continuidade e normalidade da vida . Foram 19 entrevistas, com pessoas vivendo com HIV maiores de 18 anos até 70 anos em uso de terapia antirretroviral, e matriculados em um ambulatório de imunologia de um Hospital Universitário. Da análise, emergiram cinco categorias dividas em dois eixos. Neste estudo foi trabalhado o eixo que traduziu a vida e sua continuidade no contexto de enfrentamento do HIV, abordando a normalidade e a busca pela adaptação a soropositividade. Conclui-se que os sujeitos ressignificam a vivência do cotidiano amparados no trabalho na rede social de apoio e em elementos que expressam religiosidade/ espiritualidade e se adaptam a condição de soropositividade.
Necrose avascular bilateral da cabeça femoral em paciente com Lúpus eritematoso sistêmico associado à corticoterapia prolongada: Relato de Caso
Authors: Da Silva Robert Alves , Cristina Morais da Silva Amanda , Eduardo Cardoso Carlos 
Published: July 2019

A osteonecrose da cabeça femoral é conseqüência de um infarto ósseo isquêmico que pode levar à destruição óssea, com dor e perda de função por conta da morte do tecido.
O lúpus eritematoso sistêmico e o uso prolongado de glicocorticóides apresentam-se como fatores importantes para o desenvolvimento desta patologia. Assim, o presente trabalho teve como objetivo relatar um caso de osteonecrose bilateral da cabeça femoral com manifestações pouco descritas na literatura e elucidar fatores preditivos para o desenvolvimento desta doença em pacientes com lúpus eritematoso sistêmico associado ao uso prolongado de corticóides. Adicionalmente, pretendeu-se relatar as manifestações clinicas e a terapêutica adotada para resolução deste problema. Pode-se concluir que o diagnóstico precoce desta patologia é de extrema importância e depende da avaliação clínica e de exames de imagens de alta sensibilidade, para que a área acometida possa ser revascularizada e se evite a destruição articular e uma artroplastia total do quadril.
Faktor-Faktor yang Berhubungan dengan Pemberian Dukungan Keluarga Penderita TB Paru
Authors: Sari Dian 
Published: July 2019

<p><em>Pulmonary Tuberculosis is one of the infectious diseases that become the main problem of Indonesian society. Based on a survey conducted at Andalas Public Health Centre obtained PMO (supervisor taking medicine) TB Lungless provide support to the patient of Pulmonary TB.. This study aims to determine the relationship of knowledge and attitude with the support of family as the PMO of Pulmonary TB patients. The study was conducted at the Andalas Public Health Centre Padang in 2017. The type of descriptive analytic research using a cross-sectional approach with a sample of 59 people taken from a population of 145 people PMO using simple random sampling systematic techniques. The results showed that 27.1% of PMO was not good at providing support, 32.2% knowledge was low, and 37.3% had a negative attitude. Chi-square test concluded that there is a significant correlation between knowledge (p = 0,036), and attitude (p = 0,000), with family support as PMO in Public health centre working area Andalas Padang of the year 2017. The result of this research can be used as a reference in improving TB program Lung so it can reduce the incidence of Pulmonary TB in Public health centre working area Andalas Padang.</em><em></em></p><p> </p><p><em>Tuberkulosis Paru merupakan salah satu penyakit menular yang menjadi masalah utama masyarakat Indonesia. Berdasarkan survei yang dilakukan di Puskesmas Andalas Kota Padang didapatkan sebahagian PMO (pengawas minum obat) TB Paru kurang memberikan dukungan kepada penderita TB Paru. Penelitian ini bertujuan untuk mengetahui hubungan pengetahuan dan sikap dengan dukungan keluarga sebagai PMO penderita TB Paru.Penelitian dilakukan di Wilayah Kerja Puskesmas Andalas Padang Tahun 2017. Jenis penelitian deskriptif analitik dengan menggunakan pendekatan cross sectionaldengan sampel sebanyak 59 orang yang diambil dari populasi 145 orang PMO menggunakan teknik sistematik simple random sampling. Hasil penelitian menunjukkan 27,1% PMO kurang baik dalam memberikan dukungan, 32,2% pengetahuan rendah, dan 37,3% mempunyai sikap negatif. Uji chi-square disimpulkan bahwa terdapat hubungan yang signifikan antara pengetahuan (p= 0,036), dan sikap (p=0,000), dengan dukungan keluarga sebagai PMO di Wilayah kerja Puskesmas Andalas Padang Tahun 2017. Hasil penelitian ini dapat dijadikan referensi dalam meningkatkan program TB Paru sehingga dapat menurunkan angka kejadian TB Paru di Wilayah Kerja Puskesmas Andalas Padang</em></p>
Hubungan Mutu Pelayanan Terhadap Kepuasan Pasien di Poli Fisioterapi RSU Siti Hajar
Authors: Sulaiman Sulaiman , Anggriani Anggriani 
Published: July 2019

<p><em>Good hospital services so far still seem difficult to obtain by the community when they want to seek treatment for services. Good service is a very important thing to improve patient satisfaction especially in poly physiotherapy at Siti Hajar Hospital Medan. This type of research was descriptive with a "cross sectional" design, the population in this research were 150 respondents who came to poly physiotherapy. Samples that meet the criteria in this research are 30 selected respondents. Sampling by means of "systematic sampling techniques. The purpose of this research was to analyze the relationship of factors of reliability, assurance, responsiveness, empathy, and physical evidence to the satisfaction of physiotherapy patient. The results of this research show that the majority of respondents stated that the quality of service in the poly physiotherapy at the Siti Hajar Hospital in Medan was quite good at 14 people (46.7%). These results indicate there is a relationship between the quality of physiotherapy services and satisfaction, this is evident from the results of chi-square analysis where p-value = 0.004, smaller than 0.005. The conclusion in this resarch is that the hospital gives priority to the development of the quality of physiotherapy services, especially on poly physiotherapy.</em></p><p><em><br /></em></p><p><em><em>Pelayanan rumah sakit yang maksimal selama ini masih terkesan sulit didapatkan masyarakat ketika hendak berobat untuk mendapatkan pelayanan. Pelayanan yang baik merupakan hal yang sangat penting untuk meningkatkan kepuasan pasien khususnya di poli fisioterapi RSU Siti Hajar Medan. Jenis penelitian ini deskriptif dengan rancangan “cross sectional”, populasi dalam penelitian ini sebanyak 150 orang responden yang datang ke poli fisioterapi. Sampel yang memnuhi kriteria dalam penelitian ini adalah pasien yang terpilih sebanyak 30 orang responden. Pengambilan sampel dengan cara “teknik sampling sistematis. Tujuan penelitian ini adalah untuk menganalisis hubungan faktor kehandalan, jaminan, daya tanggap, empati, dan bukti fisik terhadap kepuasan pasien fisioterapi. Hasil penelitian memperlihatkan bahwa mayoritas responden menyatakan mutu pelayanan di poli fisioterapis RSU Siti Hajar Medan adalah cukup baik yakni sebanyak 14 orang (46.7%). Hasil ini juga menunjukan ada hubungan mutu pelayanan fisioterapi dengan kepuasan, hal ini terbukti dari hasil analisis chi-square dimana p-value = 0.004, lebih kecil dari 0.005. Kesimpulan dalam Penelitian ini bahwa pihak rumah sakit memberikan prioritas pengembangan mutu pelayanan Fisioterapi terutama pada poli fisioterapi.</em></em></p>
Distinct Patterns of Daily Glucose Variability by Pubertal Status in Youth With Type 1 Diabetes
Authors: Zhu Jia , Volkening Lisa K. , Laffel Lori M. 
Published: July 2019

OBJECTIVE
To evaluate glycemia and metrics of glucose variability in youth with type 1 diabetes, and to assess patterns of 24-h glucose variability according to pubertal status.

RESEARCH DESIGN AND METHODS
Metrics of glycemia, glucose variability, and glucose patterns were assessed by using 4 weeks of continuous glucose monitoring (CGM) data from 107 youth aged 8–17 years with type 1 diabetes for ≥1 year. Glucose values per hour were expressed as percentages relative to the mean glucose over 24 h for a 4-week period. Glucose data were compared on the basis of pubertal status—prepubertal (Tanner stage [T] 1), pubertal (T2–4), and postpubertal (T5)—and A1C categories (&lt;7.5% [&lt;58 mmol/mol], ≥7.5% [≥58 mmol/mol]).

RESULTS
Youth (50% female, 95% white) had a mean ± SD age of 13.1 ± 2.6 years, diabetes duration of 6.3 ± 3.5 years, and A1C of 7.8 ± 0.8% (62 ± 9 mmol/mol); 88% were pump treated. Prepubertal youth had a higher mean glucose SD (86 ± 12 mg/dL [4.8 ± 0.7 mmol/L]; P = 0.01) and coefficient of variation (CV) (43 ± 5%; P = 0.06) than did pubertal (SD 79 ± 13 mg/dL [4.4 ± 0.7 mmol/L]; CV 41 ± 5%) and postpubertal (SD 77 ± 14 mg/dL [4.3 ± 0.8 mmol/L]; CV 40 ± 5%) youth. Over 24 h, prepubertal youth had the largest excursions from mean glucose and the highest CV across most hours compared with pubertal and postpubertal youth. Across all youth, CV was strongly correlated with the percentage of time with glucose &lt;70 mg/dL (&lt;3.9 mmol/L) (r = 0.79; P &lt; 0.0001).

CONCLUSIONS
Prepubertal youth had greater glucose variability independent of A1C than did pubertal and postpubertal youth. A1C alone does not capture the full range of glycemic parameters, highlighting the added insight of CGM in managing youth with type 1 diabetes.
Innovations for Declining Product to Extend Product Life Cycle (Case of TelX International Call Service Vinci)
Authors: Mahadi Ardianto , Dhewanto Wawan 
Published: July 2019

Change is rapid and unpredictable today. There are many emerging innovation that is used in society. There are many old and quite large today find themselves in business activities that have little promise for future growth and profit. Every firm need to manage their technologies and products, because the world is changing and new technologies emerge and the trade is shifting dynamically. Firms need to adapt, particularly in digital and telecommunication industries. Technology of internet changes the way of competition and value-creating model.

TelX International Call Service Vinci is one of PT TelX product to make an international call directly. This product is facing its decline phase according to product life cycle process. People start to leave TelX International Call Service Vinci and even do not know this product. However, this product can still give revenue for PT TelX. But, that revenue shows declining trend from over previous years. Innovation is needed to create more value for TelX International Call Service Vinci and extend the life of this product.

This research aim is to identify the factors that can influence the decline of TelX International Call Service Vinci and determine the innovations that are suitable and can be done for this product. This research uses qualitative and quantitative method. Qualitative data is collected from interview with Manager Regional Wholesale Service Telecommunication and observation in PT TelX. Quantitative data is collected through questionnaire from 70 respondents. Secondary data is collected from annual reports, journals, and books that support the research. Frameworks that used in this research are product life cycle framework and synergic innovation management model.
Decline of TelX International Call Service Vinci is caused by several factors. First is because the product has entered its mature stage. Second cause is less intensive marketing process from PT TelX for this product. Third is caused by the characteristic of customers. Low switching cost and niche market makes this product has little sales. Last factor is caused by other products that use newer technology for their products, for example the usage of internet. Innovations that are proposed for TelX International Call Service Vinci are change the packaging of TelX International Call Service Vinci and create attractive user interface for this product, partnering with VoIP (Voice over Internet Protocol) provider to create better service, and sell TelX International Call Service Vinci in bundle with other Telecommunication services.
Stochastic Analysis of the Exchange Rate of Naira, YEN, GBP, CFA and FRANC in Relation to US Dollar and Predicting the Naira for the Year 2025
Authors: Kabari Ledisi Giok , Nwamae Believe B. 
Published: July 2019

In Nigeria today, constant fluctuations of exchange rate or volatility is of great importance in one way or the other to the general public because its fluctuation has an effect on the economy. The objectives of the paper were to investigate the recent changes in the naira currency and other world currencies if there appear to be any relationship. Data was obtained from daily exchange rate of different countries’ currencies from 12/10/2005 and 2/11/2018 with 3,190 observations obtainable from the Data and statistics publication of the Central Bank of Nigeria. The study investigates the past recent changes in the naira and four foreign currencies of the world (Pounds, Yen, Cfa and Swiss Franc) and their relationship plotted as signal using MATLAB 2016a. The four currencies were randomly selected from the list of world currencies. Multiple Linear Regression was used to perform the analysis. The analysis of 3,190 observation resulted in a prediction model that has 97% prediction accuracy, which suggests that under ideal circumstances and baring any natural disaster, total collapse of the economy or major crisis like recession. The results from the model of this study suggest that fluctuation in currency exchange rate of other currencies has significance on the Nigerian exchange rate and as such should be considered when designing exchange rate policies.