bluuebunny/crossref_metadata_2025_split huggingface dataset:
Metal(II) Formates (M = Fe, Co, Ni, and Cu) Stabilized by Tetramethylethylenediamine (tmeda): Convenient Molecular Precursors for the Synthesis of Supported Nanoparticles
Authors: Margossian Tigran , Larmier Kim , Allouche Florian , Chan Ka Wing , Copéret Christophe 
Published: February 2019

Abstractγ‐Alumina supported 3d transition‐metal nanoparticles are commonly used catalysts for several industrial reactions, such as Fischer‐Tropsch, reforming, methanation, and hydrogenation reactions. However, the activity of such catalyst is often limited by the low metal dispersion and a high content of irreducible metal, inherent to the conventional preparation methods in aqueous phase. In this context, we have recently shown that [{Ni(μ2‐OCHO)(OCHO)(tmeda)}2(μ2‐OH2)] (tmeda=tetramethylethylenediamine) is a suitable molecular precursor for the formation of 1–2 nm large nanoparticles onto alumina. Here, we explore the synthesis of the corresponding Fe, Co, and Cu molecular precursors, namely [{Fe(μ2‐OCHO)(OCHO)(tmeda)}4], [{Co(μ2‐OCHO)(OCHO)(tmeda)}2(μ2‐OH2 )], [Cu(κ2‐OCHO)2(tmeda)], which are, like the Ni precursor, soluble in a range of solvents, rendering them convenient metal precursors for the preparation of supported metallic nanoparticles on γ‐alumina. Using a specific adsorption of the molecular precursor on γ‐alumina in a suitable organic solvent, treatment under H2 provides small and narrowly distributed Fe (2.5±0.9 nm), Co (3.0±1.2 nm), Ni (1.7±0.5 nm), and Cu (2.1±1.5 nm) nanoparticles. XAS shows that the proportion of MAl2O4 (M = Co, Ni, Cu) is small, thus illustrating the advantage of using these tailor‐made molecular precursors.
Effects of male postpartum depression on father–infant interaction: The mediating role of face processing
Authors: Koch Sabrina , De Pascalis Leonardo , Vivian Fabielle , Meurer Renner Anelise , Murray Lynne , Arteche Adriane 
Published: February 2019

ABSTRACTIt is estimated that postpartum depression affects up to 25% of men. Despite such high prevalence, the majority of studies on postpartum depression are focused on mothers, and the role of paternal depression and its effects on infant development have been overlooked by researchers and clinicians. The present study aimed to fill this gap by investigating the effect of paternal postpartum depression on father–infant interactions. In addition, we examined whether differences in face recognition mediated the effects of paternal postpartum depression on father–infant interactions. A total of 61 father–infant dyads (17 postpartum depression, 44 controls) took part in the study. Results revealed that compared to controls, fathers with postpartum depression had a worse pattern of interaction with their infants on measures of responsiveness, mood, and sensitivity; they also had greater difficulty in recognizing happy adult faces, but greater facility in recognizing sad adult faces. Depressed fathers attributed greater intensities to sad adult and infant faces. The tendency to attribute greater intensity to sad adult faces was confirmed as a partial mediator of the effect of paternal postpartum depression on measures of father responsiveness and as a full mediator of the effects of paternal depression on father sensitivity. Clinical implications and suggestions for further studies are discussed.
Bubbles and crises: Replicating the Anundsen et al. (2016) results
Authors: Fu Bowen 
Published: February 2019

SummaryThis paper both narrowly and widely replicates the results of Anundsen et al. (Journal of Applied Econometrics, 2016, 31(7), 1291–1311). I am able to reproduce the same results as theirs. Furthermore, I find that allowing for time‐varying parameters of early warning system models can considerably improve the in‐sample model fit and out‐of‐sample forecasting performance based on an expanding window forecasting exercise.
To pool or not to pool: What is a good strategy for parameter estimation and forecasting in panel regressions?
Authors: Wang Wendun , Zhang Xinyu , Paap Richard 
Published: February 2019

SummaryThis paper considers estimating the slope parameters and forecasting in potentially heterogeneous panel data regressions with a long time dimension. We propose a novel optimal pooling averaging estimator that makes an explicit trade‐off between efficiency gains from pooling and bias due to heterogeneity. By theoretically and numerically comparing various estimators, we find that a uniformly best estimator does not exist and that our new estimator is superior in nonextreme cases and robust in extreme cases. Our results provide practical guidance for the best estimator and forecast depending on features of data and models. We apply our method to examine the determinants of sovereign credit default swap spreads and forecast future spreads.
Raman exfoliative cytology for prognosis prediction in oral cancers: A proof of concept study
Authors: Sahu Aditi , Gera Poonam , Malik Akshat , Nair Sudhir , Chaturvedi Pankaj , Murali Krishna C. 
Published: February 2019

Oral cancer is associated with high rates of recurrence, attributable to field cancerization. Early detection of advanced field changes that can potentially progress to carcinoma can facilitate timely intervention and can lead to improved prognosis. Previous in vivo studies have successfully detected advanced field effects in oral cancers. Raman exfoliative cytology has previously shown to differentiate normal, oral pre‐cancer and cancers. The present study explores Raman‐exfoliative‐cytology‐based detection of field effects. Exfoliated cells were collected from tumor (n = 16) and contralateral‐normal appearing mucosa (n = 16) of oral cancer patients, and healthy tobacco habitués (n = 20). After spectral acquisition, specimens were Pap‐stained for cytological evaluation. Data analysis, by Principal Component Analysis and Principal Component‐Linear Discriminant Analysis, indicate several spectral‐misclassifications between contralateral normal and tumor, which were investigated and correlated with spectral, cytological and clinical outcomes. A qualitative analysis by grouping patients with number of misclassifications with tumor (Group 1: 0, Group 2: 1 and Group 3: >1) was explored. Group 3 with highest misclassifications showed spectral and cytological similarity to tumor group — one patient was a case of early inoperable residual disease, despite clear margins on histopathology. Thus, these misclassifications could be indicative of cancer field changes, and can prospectively help to identify patients susceptible to recurrences.
Engineering molecularly mobile polyrotaxane surfaces with heparin‐binding EGF‐like growth factors for improving hepatocyte functions
Authors: Arisaka Yoshinori , Yui Nobuhiko 
Published: February 2019

AbstractHepatocytes in vitro may be useful for treating various types of liver diseases, but these cells immediately lose their functions. Here, we designed sulfonated‐polyrotaxane (PRX) surfaces with immobilized heparin binding‐epidermal growth factor‐like growth factors (HB‐EGFs) for improving hepatic functions. Sulfonated‐PRX triblock copolymers, composed of sulfopropyl ether‐modified α‐cyclodextrins (α‐CDs) threaded onto a poly(ethylene glycol) (PEG) chain as a PRX segment and poly(benzyl methacrylate) at both terminals of the PEG as anchoring segments, were coated onto polystyrene surfaces by a drop cast method. The sulfonated‐PRX surfaces with a small number of threading α‐CDs induced cytoplasmic localization of yes‐associated proteins in HepG2 cells. Moreover, immobilization of HB‐EGFs onto the sulfonated‐PRX surfaces with a small number of threading α‐CDs promoted hepatic functions, including albumin secretion and gene expression. These results suggest that the combination of modulating the mobility of PRXs and immobilizing growth factors is effective for improving hepatic functions. © 2019 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 107A: 1080–1085, 2019.
Redox‐active injectable gel using polyion complex to achieve sustained release of exenatide and enhance therapeutic efficacy for the treatment of type 2 diabetes
Authors: Ishii Shiro , Sakaue Sho , Nagasaki Yukio 
Published: February 2019

AbstractTo provide sustained release of exenatide and enhance therapeutic efficacy for the treatment of type 2 diabetes compared to the existing products for exenatide, we developed an exenatide‐loaded, redox‐active, injectable gel (Exe@RIG). This injectable gel is formed by a polyion complex (PIC) comprising three components, (1) cationic polyamine–poly(ethylene glycol)–polyamine triblock copolymer possessing reactive oxygen species (ROS)‐scavenging moieties as side chains, (2) anionic poly(acrylic acid), and (3) exenatide. The mixture formed exenatide‐loaded PIC flower micelles at room temperature, which immediately converted to a gel under physiological conditions. Owing to electrostatic interactions between exenatide and the PIC gel network, RIG was able to provide sustained release of exenatide without a significant initial burst. Subcutaneous injection of Exe@RIG once a week prevented the increase in glucose concentration significantly in db/db mice compared to those in control groups. In addition, Exe@RIG suppressed the degeneration of pancreatic islets, which is reported to be caused by increased ROS. Our result indicates that Exe@RIG has the potential to provide a long acting exenatide as well as enhanced efficacy in the treatment of type 2 diabetes compared to the existing products. © 2019 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 107A: 1107–1113, 2019.
Cooperation of PU.1 With IRF8 and NFATc1 Defines Chromatin Landscapes During RANKL-Induced Osteoclastogenesis
Authors: Izawa Naohiro , Kurotaki Daisuke , Nomura Seitaro , Fujita Takanori , Omata Yasunori , Yasui Tetsuro , Hirose Jun , Matsumoto Takumi , Saito Taku , Kadono Yuho , Okada Hiroyuki , Miyamoto Takeshi , Tamura Tomohiko , Aburatani Hiroyuki , Tanaka Sakae 
Published: February 2019

ABSTRACT

Receptor activator of nuclear factor κB ligand (RANKL) induces osteoclast (OC) differentiation from bone marrow-derived macrophages (BMMs). The transcription factors nuclear factor of activated T cells 1 (NFATc1) and interferon regulatory factor (IRF) 8 play positive and negative roles, respectively, in this process. However, genomewide mapping of the active cis-regulatory elements regulating OC differentiation has not been performed, and little is known about the global landscape of OC-specific gene regulation. We used chromatin immunoprecipitation and formaldehyde-assisted isolation of regulatory elements followed by sequencing to show that PU.1 transcription factor binding motifs were overrepresented at active cis-regulatory regions in both murine BMMs and OCs, while IRF and NFAT binding motifs were selectively enriched at these regions in BMMs and OCs, respectively. We also found that RANKL induced the downregulation of Irf8 and upregulation of Nfatc1 expression, which was associated with dramatic alterations in histone modification. BMM-specific PU.1 binding sites were observed to overlap with IRF8 binding sites in BMMs, and this also occurred for OC-specific PU.1 binding sites and NFATc1 binding sites in OCs. The expression of genes with IRF8 peaks within BMM-specific PU.1 binding sites was significantly higher in BMMs than in OCs, while that of genes with NFATc1 peaks within OC-specific PU.1 binding sites was significantly higher in OCs than in BMMs. Our results suggest that PU.1 switches its transcription partner from IRF8 to NFATc1 and alters the binding regions during RANKL-induced osteoclastogenesis, which is associated with changes in epigenetic profiles and the control of cell type–specific gene expression. © 2019 American Society for Bone and Mineral Research.
Slc20a2, Encoding the Phosphate Transporter PiT2, Is an Important Genetic Determinant of Bone Quality and Strength
Authors: Beck-Cormier Sarah , Lelliott Christopher J , Logan John G , Lafont David T , Merametdjian Laure , Leitch Victoria D , Butterfield Natalie C , Protheroe Hayley J , Croucher Peter I , Baldock Paul A , Gaultier-Lintia Alina , Maugars Yves , Nicolas Gael , Banse Christopher , Normant Sébastien , Magne Nicolas , Gérardin Emmanuel , Bon Nina , Sourice Sophie , Guicheux Jérôme , Beck Laurent , Williams Graham R , Bassett J H Duncan 
Published: February 2019

ABSTRACT

Osteoporosis is characterized by low bone mineral density (BMD) and fragility fracture and affects over 200 million people worldwide. Bone quality describes the material properties that contribute to strength independently of BMD, and its quantitative analysis is a major priority in osteoporosis research. Tissue mineralization is a fundamental process requiring calcium and phosphate transporters. Here we identify impaired bone quality and strength in Slc20a2–/– mice lacking the phosphate transporter SLC20A2. Juveniles had abnormal endochondral and intramembranous ossification, decreased mineral accrual, and short stature. Adults exhibited only small reductions in bone mass and mineralization but a profound impairment of bone strength. Bone quality was severely impaired in Slc20a2–/– mice: yield load (–2.3 SD), maximum load (–1.7 SD), and stiffness (–2.7 SD) were all below values predicted from their bone mineral content as determined in a cohort of 320 wild-type controls. These studies identify Slc20a2 as a physiological regulator of tissue mineralization and highlight its critical role in the determination of bone quality and strength. © 2019 The Authors. Journal of Bone and Mineral Research Published by Wiley Periodicals Inc.
CeO2 nanoparticles synthesized through green chemistry are biocompatible: In vitro and in vivo assessment
Authors: Naz Sania , Kazmi Syeda Tayyaba Batool , Zia Muhammad 
Published: February 2019

AbstractWidespread use of cerium oxide (CeO2) nanoparticles (NPs) is found in almost all areas of research due to their distinctive properties. CeO2 NPs synthesized via green chemistry have been characterized for antioxidant, phytochemical, and biological potential. Physical characterization through scanning electron microscopy, XRD, and TGA showed that the NPs are circular in shape, 20‐25 nm in size, and stable in a wide range of temperature. NPs display significant antioxidant (32.7% free radical scavenging activity) and antileishmanial (IC50 48 µg mL−1) properties. In vitro toxicity tested against lymphocytes verified that NPs are biocompatible (99.38% viability of lymphocytes at 2.5 μg mL−1). In vivo toxicity experiments showed no harmful effects on rat serum chemistry and histology of various organs and did not even change the concentration of antioxidative enzymes, total protein contents, lipid peroxidation, and nitrosative stress. These observations are in line with the statement that plant‐based synthesis of CeO2 NPs lessens or nullifies in vitro and in vivo toxicity and hence CeO2 NPs are regarded as a safe and biocompatible material to be used in drug delivery.
Infusion of high concentration of lactate in perfused liver, simulating in vivo hyperlactatemia, prevents the reduction of gluconeogenesis in Walker‐256 tumor‐bearing rats
Authors: Frasson‐Uemura Isabele Gonçalves , Biazi Giuliana Regina , Miksza Daniele Romani , Moreira Carolina Campos Lima , Cassolla Priscila , Bertolini Gisele Lopes , Bazotte Roberto Barbosa , de Souza Helenir Medri 
Published: February 2019

AbstractGluconeogenesis (GN) is increased in patients with cancer cachexia, but is reduced in liver perfusion of Walker‐256 tumor‐bearing cachectic rats (TB rats). The causes of these differences are unknown. We investigated the influence of circulating concentrations of lactate (NADH generator) and NADH on GN in perfused livers of TB rats. Lactate, at concentrations similar to those found on days 5 (3.0 mM), 8 (5.5 mM), and 12 (8.0 mM) of the tumor, prevented the reduction of GN from 2.0 mM lactate (lactatemia of healthy rat) in TB rats. NADH, 50 or 75 μM, but not 25 μM, increased GN from 2.0 mM lactate in TB rats to higher values than healthy rats. High concentrations of pyruvate (no NADH generator, 5.0 and 8.0 mM) did not prevent the reduction of GN from 2.0 mM pyruvate in TB rats. However, 50 or 75 μM NADH, but not 25 μM, increased GN from 2.0 mM pyruvate in TB rats to similar or higher values than healthy rats. High concentration of glutamine (NADH generator, 2.5 mM) or 50 μM NADH prevented the reduction of GN from 1 mM glutamine in TB rats. Intraperitoneal administration of pyruvate (1.0 mg/kg) or glutamine (0.5 mg/kg) similarly increased the glycemia of healthy and TB rats. In conclusion, high lactate concentration, similar to hyperlactatemia, prevented the reduction of GN in perfused livers of TB rats, an effect probably caused by the increased redox potential (NADH/NAD+). Thus, the decreased GN in livers from TB rats is due, at least in part, to the absence of simulation of in vivo hyperlactatemia in liver perfusion studies.
Erlotinib inhibits colon cancer metastasis through inactivation of TrkB‐dependent ERK signaling pathway
Authors: Shen Tao , Cheng Xianshuo , Xia Cuifeng , Li Qiang , Gao Yi , Pan Dingguo , Zhang Xuan , Zhang Ce , Li Yunfeng 
Published: February 2019

AbstractThe distal metastasis is the main cause of death in patients with colon cancer. Tyrosine receptor kinase B (TrkB) and ERK signals may be the potential targets for the treatment of colon cancer metastasis. This study aims to investigate whether erlotinib inhibits distant metastasis of colon cancer by regulating TrkB and ERK signaling pathway. Human colon adenocarcinoma cell lines (SW480 and Caco‐2) pretreated with exogenous C‐X‐C motif chemokine ligand 8 (CXCL8) were used to assess the suppressive effect of erlotinib on tumor metastasis, including anoikis, epithelial‐mesenchymal transformation (EMT), migration, and invasion. Through TrkB overexpression, Akt suppression, and ERK suppression, the roles of TrkB, Akt, and ERK in erlotinib‐induced metastasis inhibition of colon cancer cells were explored. The results showed that erlotinib alleviated CXCL8‐induced metastasis of the colon cancer cells. Overexpression of TrkB in colon cancer cells eliminated the effect of erlotinib on anoikis, inhibition of EMT, migration, and invasion, and downregulation of p‐ERK and p‐Akt. Furthermore, the inhibition of ERK activation instead of Akt activation was found to participate in erlotinib‐mediated metastasis resistance, including anoikis, inhibition of EMT, migration, and invasion. In conclusion, erlotinib inhibits colon cancer cell anoikis resistance, EMT, migration, and invasion by inactivating TrkB‐dependent ERK signaling pathway.
Anti‐colorectal cancer targets of resveratrol and biological molecular mechanism: Analyses of network pharmacology, human and experimental data
Authors: Li Rong , Ma Xiuying , Song Yingqi , Zhang Yuanyuan , Xiong Wenbi , Li Li , Zhou Liming 
Published: February 2019

AbstractIn this study, colorectal cancer (CRC)‐diseased targets and resveratrol (Res)‐associated targets were combined and constructed by the use of grouped databases for identification of the predicted targets. After production of target‐functional protein interaction network of Res anti‐CRC, the topological analysis was used to create the core targets of Res anti‐CRC. All core targets performed the analyses of biological function and pathway enrichment to optimize the biological processes and key signaling pathways of Res anti‐CRC. The resultant five core therapeutic targets of Res anti‐CRC were identified as protein kinase B1 (AKT1), interleukin 6 (IL6), Tumor protein p53 (TP53), vascular endothelial growth factor, and mitogen‐activated protein kinase 1, respectively. Biological processes of Res anti‐CRC were predominantly associated with regulating apoptosis, immune response, cellular communication, signal transduction, and metabolism of the nuclide. In addition, the top 10 key signaling pathways were identified, respectively. In human CRC sample assays, CRC histologic sections showed elevated expression of AKT1 and IL6 proteins, accompanied with abnormal changes in blood molecules. In pharmacological experiments of Res anti‐CRC in vitro, Res‐treated HCT116 cells showed inhibited cell growth, induced cell death. In addition, downregulation of intracellular AKT1 and IL6 expression were checked in Res‐treated HCT116 cells. Taken together, these bioinformatic findings and preliminary validated data uncovered pharmacological molecular mechanisms associated with Res anti‐CRC, and further identified top five core therapeutic targets. Beneficially, these five predicted targets might serve as potential biomolecules for anti‐CRC treatment.
Enhanced expression of circ_0000267 in hepatocellular carcinoma indicates poor prognosis and facilitates cell progression by sponging miR‐646
Authors: Pan Hongliang , Tang Li , Jiang Hua , Li Xiuyuan , Wang Ruliang , Gao Jinxia , Li Qiang 
Published: February 2019

AbstractHepatocellular carcinoma (HCC) is a highly aggressive carcinoma worldwide. Circular RNAs (circRNAs) have been proved to be involved in the pathogenesis of several carcinomas. circ_0000267 was reported to be elevated in HCC tissue samples by circRNA microarray. In this study, quantitative reverse‐transcription polymerase chain reaction was induced to further detect the expression of circ_0000267 in HCC tissues and cells. The clinical significance was also explored by Fisher’s exact test, Kaplan‐Meier curves and Cox regression analysis. Cell counting kit‐8, colony formation, flow cytometry and transwell experiments were conducted on HCC cells to elucidate the functions of circ_0000267. Dual‐luciferase reporter assay was induced to explore the mechanism of circ_0000267. Moreover, rescue experiments were also performed on HCC cells. As a result, circ_0000267 was enhanced in HCC tissues and cell lines. This upregulation is associated with patients’ clinical severity and poor prognosis. Functionally, circ_0000267 could facilitate cell growth, migration and invasion and attenuate cell apoptosis in HCC cells. Mechanistically, circ_0000267 could directly sponge miR‐646 to exert its oncogenic properties. In summary, we identified a novel HCC‐associated circRNA in the progression of this fatal disease.
Adverse childhood experiences, self‐care, and compassion outcomes in mental health providers working with trauma
Authors: La Mott Julee , Martin Luci A. 
Published: February 2019

AbstractObjectiveThis study examined the moderating effects of self‐care on various compassion outcomes among mental health providers.MethodMental health providers (n = 371; 94.1% female; mean age = 47.12) were surveyed regarding their level of self‐care, history of adverse childhood experiences, and the degree of burnout, secondary traumatic stress, and compassion satisfaction experienced.ResultsResults indicated that providers who endorsed a history of adverse childhood experiences (82.5%) also endorsed greater negative compassion outcomes than those who did not have such a history. Endorsement of self‐care activities was a significant predictor of compassion satisfaction and burnout in the expected directions. Self‐care served as a moderator between adverse childhood experiences and burnout.ConclusionsSelf‐care is an effective method for decreasing negative compassion outcomes among mental health providers who work with trauma. It is important to develop effective training programs that promote self‐care in personal and professional settings.