bluuebunny/crossref_metadata_2025_split huggingface dataset:
Patient‐reported symptoms and signs of moderate‐to‐severe psoriasis treated with guselkumab or adalimumab: results from the randomized VOYAGE 1 trial
Authors: Papp K.A. , Blauvelt A. , Kimball A.B. , Han C. , Randazzo B. , Wasfi Y. , Shen Y.‐K. , Li S. , Griffiths C.E.M. 
Published: March 2018

AbstractBackgroundHow patients experience the symptoms/signs of psoriasis is highly relevant for assessing treatment response.ObjectivesCompare outcomes with guselkumab, placebo and adalimumab utilizing the novel, validated Psoriasis Symptoms and Signs Diary (PSSD).MethodsVOYAGE 1 is an ongoing, phase III, double‐blinded, controlled trial of patients with moderate‐to‐severe psoriasis. Patients were randomized to guselkumab 100 mg every 8 weeks; placebo‐to‐guselkumab 100 mg every 8 weeks; or adalimumab 40 mg every 2 weeks. The PSSD was self‐administered to assess symptoms (i.e. itch, skin tightness, burning, stinging and pain) and signs (i.e. dryness, cracking, scaling, shedding/flaking, redness and bleeding) of psoriasis (0–10 [absent‐to‐worst‐imaginable]) every 24 h. Symptom and sign summary scores were derived (0–100) based on average scores of the individual symptoms and signs. Proportions of patients with clinically meaningful improvements and symptom‐ and sign‐free scores of 0 were evaluated across treatment groups at weeks 16, 24 and 48.ResultsAt baseline, 652 of 837 randomized patients had PSSD scores. The proportion of patients achieving clinically meaningful improvements in PSSD summary scores was significantly higher in the guselkumab group compared with the placebo group at week 16 (P < 0.001) and compared with the adalimumab group at weeks 24 (P = 0.002) and 48 (P < 0.001). The proportions of patients achieving PSSD symptom and sign summary scores of 0 (i.e. symptom‐ and sign‐free) were significantly higher for guselkumab vs. placebo at week 16 and vs. adalimumab at weeks 24 and 48 (all P < 0.001).ConclusionsBased on PSSD scores, greater improvements in symptoms and signs of psoriasis were reported by patients treated with guselkumab compared with placebo at week 16 or adalimumab through 48 weeks.
Determination of multiple mycotoxin residues in Panax ginseng using simultaneous UPLC‐ESI‐MS/MS
Authors: Bi Bo , Bao Jingshan , Xi Guangsheng , Xu Yonghua , Zhang Lianxue 
Published: March 2018

AbstractPresented here is an optimized and validated high‐throughput method for the simultaneous determination of 11 different classes of mycotoxins from the popular traditional Chinese medicine Panax ginseng. The selected mycotoxins included the aflatoxins B1, B2, G1, and G2 and the fumonisins B1 and B2, as well as CIT, HT‐2, T‐2, zearalenone, and ochratoxin A. This high‐throughput analysis was achieved using a simple pretreatment procedure with no clean‐up and featured the convenient and fast‐speed determination provided by LC‐MS/MS within 12 min, for the qualitative and quantitative analysis of 11 selected mycotoxins. We sought to optimize the MS parameters and UPLC conditions and multiple reaction monitoring was used in both positive and negative electrospray ionization mode. Matrix‐matched calibration was applied for the quantification of the 11 mycotoxins in P. ginseng, within the range of 0.5–250 ng/ml. Validation of this method was performed by analyzing samples spiked at three different levels (low, medium, and high). The limits of detection and quantification of the method was within the ranges of 0.25–50 ng/ml and 0.1–25 ng/ml, respectively. Finally, this analytical method was successfully used to assess 10 separate batches of P. ginseng samples obtained from local markets and only one sample detected FB2.Practical applicationsPanax ginseng has been widely used as a highly valued and popular medicinal herb for thousands of years. The potential presence of multiple mycotoxins in P. ginseng is a key issue for its safety and has caused great public concern. In this study, a fast and easy UPLC‐ESI‐MS/MS analytical method coupled with a simple pretreatment procedure was established and validated for simultaneous determination of 11 of the most crucial mycotoxins (AFG2, AFG1, AFB2, AFB1, CIT, FB1, FB2, HT‐2 T‐2 ZON, and OTA) in 10 batches of P. ginseng samples, to ensure the quality of TCMs as well as protect the health of humans and animals.
Association between pathologic grade and multiphase computed tomography enhancement in pancreatic neuroendocrine neoplasm
Authors: Kang Jinwoo , Ryu Ji Kon , Son Jun Hyuk , Lee Jae Woo , Choi Jin Ho , Lee Sang Hyub , Kim Yong‐Tae 
Published: March 2018

AbstractBackground and AimPancreatic neuroendocrine neoplasms (PanNENs) are rare diseases but gradually increasing in prevalence with different prognosis. Multiphase contrast‐enhanced computed tomography (CT) is known as widely used imaging modality for the diagnosis of pancreatic tumors. We aimed to investigate whether CT enhancement pattern is associated with the pathologic tumor grade and can predict that of PanNEN.MethodsNinety PanNEN patients who underwent multiphase enhanced CT before pathologic diagnosis were retrospectively reviewed. CT enhancement values at each phase were measured, and its relation with pathologic grade was assessed.ResultsNinety PanNENs included 62 G1 (68.9%), 21 G2 (23.3%), and 7 G3 (7.8%). The enhancement values of the early arterial phase were significantly different among three groups (G1 119.4 HU, G2 94.7 HU, and G3 64.8 HU; G1 vs G2, P = 0.043; G1 vs G3, P = 0.001; and G2 vs G3, P = 0.027). In the late arterial phase, there was a difference between grade 1/2 and 3 but no significant difference between grade 1 and grade 2 (G1 164.3 HU, G2 142.9 HU, and G3 94.1 HU; G1 vs G2, P = 0.804; G1 vs G3, P = 0.016; and G2 vs G3, P = 0.022). The enhancement value of the portal phase did not differ significantly among the three groups. Diagnostic ability of the early arterial enhancement value for the differentiation of the G1 (cutoff 109.5 HU, sensitivity 73.3%, and specificity 62.5%) was comparable with that of the tumor size (cutoff 20.5 mm, sensitivity 68.9%, and specificity 66.7%).ConclusionsComputed tomography enhancement value at early arterial phase and its changing pattern can be a useful predictor for the differentiation of pathologic grade of PanNENs.
Influences on Care Preferences of Older People with Advanced Illness: A Systematic Review and Thematic Synthesis
Authors: Etkind Simon N. , Bone Anna E. , Lovell Natasha , Higginson Irene J. , Murtagh Fliss E. M. 
Published: March 2018

ObjectivesTo determine and explore the influences on care preferences of older people with advanced illness and integrate our results into a model to guide practice and research.DesignSystematic review using Medline, Embase, PsychINFO, Web of Science, and OpenGrey databases from inception to February 2017 and reference and citation list searching. Included articles investigated influences on care preference using qualitative or quantitative methodology. Thematic synthesis of qualitative articles and narrative synthesis of quantitative articles were undertaken.SettingHospital and community care settings.ParticipantsOlder adults with advanced illness, including people with specific illnesses and markers of advanced disease, populations identified as in the last year of life, or individuals receiving palliative care (N = 15,164).MeasurementsThe QualSys criteria were used to assess study quality.ResultsOf 12,142 search results, 57 articles were included. Family and care context, illness, and individual factors interact to influence care preferences. Support from and burden on family and loved ones were prominent influences on care preferences. Mechanisms by which preferences are influenced include the process of trading‐off between competing priorities, making choices based on expected outcome, level of engagement, and individual ability to form and express preferences.ConclusionFamily is particularly important as an influence on care preferences, which are influenced by complex interaction of family, individual, and illness factors. To support preferences, clinicians should consider older people with illnesses and their families together as a unit of care.
Success rates and factors associated with failure of temporary anchorage devices: A prospective clinical trial
Authors: Aly Shehab A. , Alyan Doha , Fayed Mona S. , Alhammadi Maged S. , Mostafa Yehya A. 
Published: March 2018

AbstractAimThe objective of the present study was to investigate success rates and associated factors affecting temporary anchorage device (TAD) failure in different biomechanical applications.MethodsA total of 180 TADs were used as a part of 82 patients’ treatment plan (24 males and 58 females); their mean age was 21.41 years. Three types of TADs were used: 50 (3M ESPE, Neuss, Germany), 56 (Bone screw; Jeil Medical, Seoul, Korea), and 74 (Morelli, Sorocaba, Brazil). Eight maxillary and four mandibular sites were selected for insertion. Three different lengths (6, 8, and 10 mm) and three different diameters (1.5, 1.6, and 1.8 mm) were used. The force levels were set at 50, 100, 150, 200, and 250 g. Patient‐, implant‐, and operator‐dependent factors were evaluated throughout the 266 days of function. Qualitative variables were described by proportions and percentages and analyzed using χ2 test.ResultsThe overall success rate was 82.2%. The higher age group showed a significantly higher success rate. Oral hygiene showed a statistically‐significant (P ˂ .05) difference between both success and failure groups. All other patient‐related factors showed no significant differences. Regarding force levels used, the highest success rate was in 250 g and the lowest was in 100 g. There were no significant differences between both groups regarding other implant‐ and operator‐related factors.ConclusionsTemporary anchorage devices have a good success rate and are beneficial to be integrated in orthodontic treatment planning. Patient age, oral hygiene, and force level are the most significant factors affecting TAD success.
Determinants of health‐related quality of life among outpatients with acute coronary artery disease after percutaneous coronary intervention
Authors: Kim Hee Sun , Kim Hyun Kyung , Kang Kyung Ok , Kim Yi Sik 
Published: March 2018

AbstractAimThis study aimed to identify health‐related quality of life (HRQoL) and its determinants in outpatients with acute coronary syndrome (ACS) after percutaneous coronary intervention.MethodsA cross‐sectional design was used and a total of 124 Korean participants was enrolled. The HRQoL (physical limitations, treatment satisfaction, and disease perception), symptom experience (frequency, severity, and distress), physiological (left ventricular ejection fraction and lipids), psychological (depression and anxiety), and situational (social support) factors were measured, selected on the basis of the theory of unpleasant symptoms. The HRQoL was assessed by using the Seattle Angina Questionnaire‐Korean, designed to evaluate disease‐specific health outcomes in patients with coronary artery disease. Descriptive statistics and multiple linear regression analyses were conducted.ResultsThe mean age of the participants was 61.73 years. The HRQoL was moderate. Among the HRQoL domains, disease perception showed the lowest level. The most intense symptoms that were experienced by the participants were fatigue, shortness of breath, and chest discomfort. More than half of the participants had depression and anxiety. The determinants of worse HRQoL were severe symptom experience, higher depression, higher low‐density lipoprotein cholesterol, a lower educational level, and lower social support.ConclusionThis study proposes a comprehensive approach to health care that incorporates symptom experience, as well as the physiological, psychological, and situational aspects based on the theory of unpleasant symptoms, to improve the HRQoL among outpatients with ACS. Nurses should play a key role to help patients with ACS to deal with the symptoms, low‐density lipoprotein cholesterol, and depression and to promote social support, particularly in less‐educated patients, in order to improve their HRQoL.
Role of G protein‐coupled receptor kinase 2 in oxidative and nitrosative stress‐related neurohistopathological changes in a mouse model of sepsis‐associated encephalopathy
Authors: Kawakami Masaaki , Hattori Mizuki , Ohashi Wakana , Fujimori Toshio , Hattori Kohshi , Takebe Mariko , Tomita Kengo , Yokoo Hiroki , Matsuda Naoyuki , Yamazaki Mitsuaki , Hattori Yuichi 
Published: March 2018

AbstractSepsis‐associated encephalopathy (SAE), characterized as diffuse brain dysfunction and neurological manifestations secondary to sepsis, is a common complication in critically ill patients and can give rise to poor outcome, but understanding the molecular basis of this disorder remains a major challenge. Given the emerging role of G protein‐coupled receptor 2 (GRK2), first identified as a G protein‐coupled receptor (GPCR) regulator, in the regulation of non‐G protein‐coupled receptor‐related molecules contributing to diverse cellular functions and pathology, including inflammation, we tested the hypothesis that GRK2 may be linked to the neuropathogenesis of SAE. When mouse MG6 microglial cells were challenged with lipopolysaccharide (LPS), GRK2 cytosolic expression was highly up‐regulated. The ablation of GRK2 by small interfering RNAs (siRNAs) prevented an increase in intracellular reactive oxygen species generation in LPS‐stimulated MG6 cells. Furthermore, the LPS‐induced up‐regulation of inducible nitric‐oxide synthase expression and increase in nitric oxide production were negated by GRK2 inhibitor or siRNAs. However, GRK2 inhibition was without effect on overproduction of tumor necrosis factor‐α, interleukin (IL)‐6, and IL‐1β in LPS‐stimulated MG cells. In mice with cecal ligation and puncture‐induced sepsis, treatment with GRK2 inhibitor reduced high levels of oxidative and nitrosative stress in the mice brains, where GRK2 expression was up‐regulated, alleviated neurohistological damage observed in cerebral cortex sections, and conferred a significant survival advantage to CLP mice. Altogether, these results uncover the novel role for GRK2 in regulating cellular oxidative and nitrosative stress during inflammation and suggest that GRK2 may have a potential as an intriguing therapeutic target to prevent or treat SAE.
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A BIBLIOMETRIC ANALYSIS OF THE TOP FIVE ECONOMICS JOURNALS DURING 2012–2016
Authors: Wei Guangyue 
Published: March 2018

AbstractThis study presents a bibliometric analysis of the top five economics journals during the period 2012–2016 and provides helpful insights into the document types, the distribution of country/territories, the distribution of institutions, the geographical distribution of authors, the most active authors and their research interests or fields, the co‐authorship network, and global/local cooperation. This paper also provides valuable information about the core historical references and the hottest new papers through co‐citation analysis and citation analysis. A co‐word analysis based on the keywords and thematic noun‐phrases in the titles and abstracts of the sample papers was used to explore the hot research topics in the top five journals (e.g. ‘price’, ‘game’, ‘consumption’, ‘income’, ‘international trade’, ‘employment’, ‘monetary policy’, ‘welfare effects’ and ‘developing countries’). In addition, a comparative keyword analysis was used to explore the differences in the directions and characteristics of each journal and the changes in research focuses between ‘new’ and ‘old’ studies. The analytical methods of this study differ from those of reviews or previous studies, and the results fill the gaps not covered by those works.
CONDITIONAL DURATION MODELS FOR HIGH‐FREQUENCY DATA: A REVIEW ON RECENT DEVELOPMENTS
Authors: Bhogal Saranjeet Kaur , Thekke Variyam Ramanathan 
Published: March 2018

AbstractThis paper reviews the recent literature on conditional duration modeling in high‐frequency finance. These conditional duration models are associated with the time interval between trades, price, and volume changes of stocks, traded in a financial market. An earlier review by Pacurar provides an exhaustive survey of the first and some of the second generation conditional duration models. We consider almost all of the third‐generation and some of the second‐generation conditional duration models. Notable applications of these models and related empirical studies are discussed. The paper may be seen as an extension to Pacurar.
How Pricing Teams Develop Effective Pricing Strategies for New Products
Authors: Feurer Sven , Schuhmacher Monika C. , Kuester Sabine 
Published: March 2018

Companies increasingly rely on pricing teams to master the complexity of pricing a new product. However, little is known about how firms should design such pricing teams. In this study, pricing teams are defined as two or more professionals within a firm who are formally or informally involved in the decision‐making process with regard to the pricing strategy for a new product. Drawing on the information‐processing view of organizational design, this study presents a framework of how pricing teams develop effective pricing strategies for such new products. Specifically, the authors provide evidence that rationality and intuition are two key pricing team information‐processing modes that drive the effectiveness of a new product's pricing strategy. The authors examine how pricing team characteristics—stability, experience, size, autonomy, and functional diversity—enable pricing teams to apply rationality and intuition when developing a new product's pricing strategy. Using data gathered from managers involved in pricing team decisions, the authors demonstrate that pricing teams can be designed to enable the application of pricing team rationality and intuition in this realm, thereby driving effectiveness of the pricing strategy. Product innovativeness moderates these relationships. Specifically, while pricing team rationality has an unambiguously positive effect on pricing strategy effectiveness, pricing team intuition is functional for high levels of product innovativeness and dysfunctional for low levels of product innovativeness. Consequently, managers should not inhibit intuitive decision‐making processes under all circumstances but allow intuition to complement rational decision‐making in the development of pricing strategies for really new products. Choosing the right pricing team design can facilitate the effective use of rationality and intuition.Practitioner Points

Companies frequently employ pricing teams to master the complexity of developing pricing strategies for new products.
In the case of incrementally new products, pricing team members should be experienced but membership should remain stable throughout the pricing strategy task to curb the use of intuition.
In the case of really new products, pricing team members should also be experienced but membership should fluctuate throughout the pricing strategy task to facilitate the use of intuition.
Managers should not inhibit intuitive decision‐making processes under all circumstances but allow intuition to complement rational decision‐making in the development of pricing strategies for really new products.
Retrospectively analysing condition in historical samples of birds
Authors: Møller A. P. , Laursen K. , Hobson K. A. 
Published: March 2018

AbstractLarge amounts of nitrogen are used as fertilizer across the globe annually exceeding 100 million metric tons, with consequences for primary productivity and effects at higher trophic levels. We measured δ15N values in feathers from samples of eidersSomateria mollissimawintering on the Danish coast in 2014‐2016 and a century ago, using museum specimens. Blue musselsMytilus edulisare filter feeders relying on phytoplankton as food and they constitute the main diet of eiders. Feather δ15N increased by 40% during the past century reflecting increased terrestrial runoff of N through agricultural use of fertilizer, in turn supporting increased primary production in shallow coastal systems. This increase in δ15N was associated with an increase in body mass and longer duration of moult. However, there was a recent decrease in the quality of feathers as reflected by more fault bars and a higher degree of feather wear suggesting that longer duration of moult comes at a cost in terms of poorer feather quality. These findings imply that terrestrial nitrogen subsidies to coastal marine systems from anthropogenic sources has profound effects on species such as the eider as revealed by the effects on body condition and plumage quality and hence the ability to fly and dive.
The pleasures of reading non‐fiction
Authors: Alexander Joy , Jarman Ruth 
Published: March 2018

AbstractThis article examines data gathered in a broader study of a school‐based reading challenge to children aged from 8 to 14 to read science information books, centred in their school or class library. A survey was conducted before they embarked on the reading challenge to establish the children's reading habits. After the period of time allotted to the challenge had ended, participating teachers and children completed questionnaires and a sample from each were interviewed. Evidence relating to reading non‐fiction for pleasure was identified and extracted from the dataset and analysed. Prior to the challenge, most children's attitude to science books was that they would be boring, difficult or at variance with what they perceived as their reader identity. More positive attitudes resulted from taking part in the challenge. Contemporary science information books were found to be in themselves a source of pleasure. It is concluded that it is possible to differentiate between the pleasures of fiction and non‐fiction and that different types of pleasure which are derived from reading science non‐fiction can also be differentiated, ranging from extrinsic to intrinsic and including efferent and aesthetic. A tentative typology of intrinsic pleasures is proposed.
Collecting the Puerto Rican Colony: Spanish‐American War Material Encounters between Officer‐Wives and Puerto Ricans
Authors: Guzmán Amanda J. 
Published: March 2018

AbstractWithin a current moment characterized by widespread diaspora and debate about national identities, the American commonwealth of Puerto Rico stands at an economically perilous, politically liminal classificatory intersection as both American and a “cultural other.” This article presents an on‐the‐ground, collection‐oriented intervention for documenting and interpreting the origins of the island's complex colonial relationship with the United States. Tacking between objects, texts, and photographs, the historical context of the Spanish‐American War is explored through the case study of the Puerto Rican Ethnological Collection at the Smithsonian Institution's National Museum of Natural History (NMNH). TheNMNH's assemblage reveals previously unrecognized intercultural exchanges between officer‐wife collectors (collectors who were the wives of military officers stationed in Puerto Rico) and local makers. The perspectives of these two differentially disenfranchised, yet agential, groups, which formed part of the ideological formation of Puerto Rico within a nationalist museum imaginary, simultaneously reconstruct and complicate Puerto Rican narratives. [Puerto Rico, Caribbean, Spanish‐American War, women collectors, miniatures]