bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Role of Taxes in the Disconnect Between Corporate Performance and Economic Growth
Authors: Khan Urooj , Nallareddy Suresh , Rouen Ethan 
Published: August 2019

We investigate the relation between corporate performance and overall economic growth in the United States. In particular, we focus on the impact of the U.S. corporate tax regime on this relation. Exploiting time-series variation and a tax shock, we document that the relatively higher corporate income tax rate and the tax treatment of foreign earnings of U.S. corporations have contributed to a disconnect between the performance of the corporate sector and the overall economy. Specifically, the growth of domestic (national) corporate profits, on average, has outpaced the growth of the domestic (national) economy, and this disconnect increases as the difference between the U.S. corporate income tax rate and the average tax rate of the other Organisation for Economic Co-operation and Development countries increases. The underlying mechanism is fewer corporate profits being channeled into subsequent domestic investments when the U.S. tax rate is relatively higher, leading to lower economic growth. Our findings have implications for policy setters. This paper was accepted by Brian Bushee, accounting.
Persepsi, Sikap dan Minat Pariwisata Halal di Daerah Istimewa Yogyakarta
Authors: Sari Firdausa Kumala , Safitri Novita , Anggraini Wahyu 
Published: August 2019

Penelitian ini bertujuan untuk menguji Theory of Planned Behavior (TPB) mengenai pengaruh persepsi konsep pada sikap, persepsi perkembangan pada sikap, dan sikap pada minat masyarakat DIY tentang pariwisata halal. Rancangan penelitian ini deskriptif dan korelasional yang melibatkan 435 subyek dari Daerah Istimewa Yogyakarta, mengumpulkan data melalui survei dengan mengisi kuesioner. Pengaruh persepsi konsep pada sikap DIY tentang pariwisata halal diuji menggunakan teknik analisis data dengan SB-SEM (Covariance Based-Structural Equation Modelling) dengan softwere AMOS. Penelitian ini menunjukkan bahwa ada pengaruh anatara persepsi dan sikap pada minat masyarakat dalam pariwisata halal. Persepsi masyarakat tentang pariwisata halal terletak pada fasilitasnya. Kriteria fasilitas termasuk dalam salah satu kriteria GMTI (Global Muslim Travel Index). Pemerintah diharapkan memprioritaskan pengembangan fasilitas wisata halal.
EL JUICIO POR JURADOS POPULARES: LA EXPERIENCIA EN LA PROVINCIA DEL NEUQUÉN
Authors: Martini Florencia María 
Published: August 2019

El ensayo analiza el Derecho Penal en su faz ejecutiva y los derechos de los sujetos que habitan en las fronteras socioculturales internas a los Estados, encubiertas por la “norma” estatal que sintetiza la mirada y disciplina. Devela el funcionamiento de nuevos dispositivos de participación ciudadana que horadan la unidad impuesta por la norma, abriendo la trama y permitiendo en ese proceso, el ejercicio real y efectivo de los derechos de ciudadanos culturalmente diversos (implicando el derecho a la diferencia, la discriminación positiva y su proyección en la toma de decisiones de la res pública como cosa de todos). Se trata del Jurado Popular, instituido en la Provincia del Neuquén que asigna competencia a los ciudadanos para el juzgamiento de conciudadanos acusados de cometer delitos graves contra las personas y la integridad sexual. Doce ciudadanos de distinta extracción sociocultural, con equitativa proporción de hombres y mujeres, que deliberan, argumentan y deciden en condición de simetría recíproca. Sumado ello el instituto faculta la integración del jurado con integrantes de los pueblos originarios cuando el hecho a juzgar comprometa el modo de resolución de conflictos de la comunidad, garantizando la diversidad cultural. Se tiende, de este modo, a la democratización profunda de la justicia y a proveer a su legitimación política y social, aspirando a la toma de decisiones más justas, con el compromiso de los conciudadanos de asumirse como participantes en el proceso del juzgar a sus pares.Palabras claves: Interculturalidad; Jurado Popular.
A Phase II Study of Irinotecan and Etoposide as Treatment for Refractory Metastatic Breast Cancer
Authors: Segar Jennifer M. , Reed Darien , Stopeck Alison , Livingston Robert B. , Chalasani Pavani 
Published: August 2019

Abstract

Lessons Learned
The combination of irinotecan and etoposide showed modest efficacy in terms of response rate in the refractory setting for patients with metastatic breast cancer. The studied dose and schedule of irinotecan and etoposide is very toxic, with &gt;70% grade 3 or 4 treatment-related adverse events.

Background
As single agents, both irinotecan and etoposide have documented activity against breast cancer among patients who have received multiple lines of prior chemotherapy. Irinotecan interacts with topoisomerase I (Topo I) to stabilize its cleavable complex, and etoposide has an analogous interaction with topoisomerase II (Topo II). This stabilization without rapid resealing of the cleavage point results in apoptotic cell death and accounts for the antitumor activity of these agents. Topo II levels may increase after administration of a Topo I inhibitor, thus providing a rationale for combining these agents in practice. Based on preclinical data, we conducted a phase II trial of the Topo I inhibitor irinotecan combined with the Topo II inhibitor etoposide in patients with metastatic breast cancer (MBC).

Methods
This was a single-arm phase II clinical trial in patients with MBC refractory to prior anthracycline, taxane, and capecitabine therapy. All patients were treated with oral etoposide at 50 mg/day on days 1–14 and intravenous irinotecan at 100mg/m2 on days 1 and 15. Treatment cycles were repeated every 28 days. The primary endpoint was median time to progression. Secondary end points included overall clinical response rate using RECIST criteria and assessing the toxicity and safety profile associated with this combination regimen.

Results
We enrolled 31 women with refractory MBC to our trial. Median age was 54 (range, 36-84), with the majority (64%) having hormone receptor positive (HR+) human epidermal growth factor receptor 2 negative (HER2 neg) MBC. Median number of prior therapies was five (range, 3–14). Efficacy was evaluated in 24 patients. Seventeen percent had a partial response, and 38% had stable disease as best response. Median progression-free survival was 9 weeks (range, 3–59). All 31 patients were evaluable for toxicity assessment, and 22 patients (71 %) experienced treatment-related grade 3 or 4 adverse events (AEs; Table 1). The most common grade 3–4 AE was neutropenia. The study was terminated early based on interim analysis assessment that suggested toxicities outweighed the efficacy.

Conclusion
Irinotecan and etoposide demonstrated only modest clinical activity and poor tolerability in patients with MBC refractory to anthracycline, taxane, and capecitabine therapy. Further studies testing a lower dose and/or different schedule could be considered given ease of administration and responses seen.
Localisation value of ictal arterial spin‐labelled sequences in partial seizures
Authors: Toledo Manuel , Munuera Josep , Salas‐Puig Xavier , Santamarina Estevo , Lacuey Nuria , Rovira Alex 
Published: August 2019

ABSTRACTPerfusion‐based magnetic resonance imaging (MRI) using pulsed arterial spin‐labelled (ASL) sequences is becoming a more commonly used tool for the diagnosis of patients with focal epilepsy. We report a patient with post‐traumatic epilepsy and cortical haemorrhage who had a complex partial seizure characterised mainly by ictal speech (verbalisation) during MRI acquisition. Ictal ASL showed focal hyperperfusion over the right temporal region which had resolved on follow‐up MRI, two weeks later. Seizure semiology and interictal EEG suggested seizure origin in the non‐dominant temporal lobe, which matched the increased ictal blood flow observed by ASL. The patient had language dominance in the left hemisphere, as observed by functional MRI. Our findings suggest that focal hyperperfusion, as observed by ASL, may have localising value in temporal epilepsies when performed in the ictal period.
Predictive factors of ictal SPECT findings in paediatric patients with focal cortical dysplasia
Authors: Kudr Martin , Krsek Pavel , Maton Bruno , Malone Stephen , Jahodova Alena , Jezdik Petr , Komarek Vladimir , Miller Ian , Jayakar Prasanna , Resnick Trevor , Duchowny Michael 
Published: August 2019

ABSTRACTAims. To identify variables that influence the extent of ictal single‐photon emission computed tomography (SPECT) findings in paediatric patients with focal cortical dysplasia (FCD). Methods. We visually evaluated 98 ictal SPECT studies from 67 children treated surgically for intractable epilepsy caused by FCD. SPECT findings were classified as “nonlocalised”, “well‐localised”, and “extensive” and compared with parameters of injected seizures (seizure type and duration, injection time, and scalp EEG ictal pattern), presence of structural pathology on MRI, type of surgery performed after SPECT study, and histological findings. Results. A shorter injection time and duration of injected seizure was associated with more localised SPECT hyperperfusion. SPECT findings were not significantly influenced by type of injected seizure. Widespread ictal scalp EEG patterns were associated with extensive SPECT findings. Larger zones of hyperperfusion were more common in patients with lesional MRI and patients undergoing multilobar resections. SPECT studies demonstrating good localisation were more common in patients with mild malformations of cortical development. Conclusion. Early ictal SPECT radiotracer injection is crucial for successful localisation of the epileptogenic zone. Seizure duration, type of scalp EEG findings, and presence of structural pathology on MRI may influence the extent of ictal SPECT hyperperfusion, which was associated with certain types of epilepsy surgery as well as histopathological findings.
Social Attitudes towards Homosexuality in Hungary and Romania
Authors: Takács Judit , Szalma Ivett 
Published: August 2019

This study examines social attitudes towards homosexuality in two Central-Eastern European neighbouring countries – Romania and Hungary – with many common points, but that do differ in their religious traditions.
Our main research question is whether the main religious denomination can influence social attitudes towards homosexuality, after controlling for all the important individual level variables (gender, age, education, type of settlement, family status, employment background, and attitudes related to family and gender norms). Among the examined variables we especially focus on the religious ones since the dominant denominations are different in these otherwise similar societies.
The empirical base of our study comprises two longitudinal databases: the European Social Survey (ESS) and the European Values Study (EVS). We use data from two ESS rounds (of 2006 and 2008) and three EVS rounds (of 1990, 1999 and 2008). Since Romania participated only in the 3rd and the 4th rounds of the ESS (in 2006 and 2008), the Romanian results from 2008 are the most recent ones.
We apply descriptive statistics and regression models. Our main conclusion is that belonging to the Orthodox Church had a more negative effect on social attitudes towards homosexuality than belonging to the Catholic Church (as previous studies have also found).
From Petty Corruption to Criminal State
Authors: Magyar Bálint , Madlovics Bálint 
Published: August 2019

Offering a decent database easily applicable to cross-country comparison, Transparency International’s Corruption Perceptions Index (CPI) has been widely used as a variable for showing the level of corruption. However, surveys of its sources are based on presumptions which mainly apply to bottom-up forms of corruption, namely free market corruption and bottom-up state capture, and therefore it is insufficient for assessing the state of a country plagued by top-down types of the former. We provide an analytical framework that distinguishes four levels of corruption and draws on the experience of the post-communist region. Using this framework to analyze the CPI’s survey questions, we explain why the index provides a blurred picture of the region. ‘Big data’ evidence for top-down corruption in Hungary is also presented, signifying the need for a more refined index.
A influência da escolaridade no uso de suplementos alimentares
Authors: Prezotto Marina Destéfano , Trevisan Mara Cléia 
Published: August 2019

Este estudo teve como objetivo comparar o uso de suplementos alimentares entre indivíduos com alta e baixa escolaridade os quais são praticantes de atividade física em academias de Uberaba-MG. A amostra foi composta por 660 pessoas, com idade acima de 18 anos de ambos os gêneros. Foi utilizado questionário autoaplicável, padronizado, de múltipla escolha, previamente testado. Para análise dos dados foi utilizada a estatística descritiva e o teste Qui-quadrado, por meio do Software SPSS 17 com p-Valor<0,05. É expressiva a prevalência de uso de suplementos alimentares, 317 (48%), principalmente entre os indivíduos com alta escolaridade 234 (35,5%). Não houve diferença estatística entre o uso de suplementos nos diferentes níveis de escolaridade, entretanto entre os que utilizam, os com alta escolaridade em sua maioria 61 (9,2%) fazem uso de 2 suplementos, enquanto os com baixa escolaridade em sua maioria 66 (10%), utilizam apenas 1 tipo de suplemento. Os indivíduos com alta escolaridade consomem preferencialmente mais de um tipo de suplemento 161 (50,7%), sendo os ricos em proteínas 35 (11%), anabolizantes 9 (2,8%) os mais consumidos. Já entre os indivíduos com baixa escolaridade se destacam entre os mais consumidos, os ricos em proteínas 18 (5,6%) e BCAA 4 (1,2%). Sendo assim, o nível de escolaridade não interfere no uso de suplementos alimentares por praticantes de atividade física em academias, porém o uso de suplementos é expressivo nesta população.
Orientação profissional em atividade física e alimentação: um estudo de caso
Authors: Estevam Thaynara Nathalie Carvalho , Simplício Mayla De Paula Torres , Oliveira Guilherme Pereira , Almeida Michele Aparecida , Pussieldi Guilherme De Azambuja , Simplício Afonso Timão , De Faria Valéria Cristina 
Published: August 2019

Objetivo: Verificar os benefícios da orientação conjunta da educação física e nutrição sobre o condicionamento cardiovascular, parâmetros antropométricos e bioquímicos após quatro meses de intervenção. Métodos: Foi selecionado um participante do Espaço Movimento, do sexo feminino, com 60 anos de idade e hipertensa. A intervenção foi realizada por quatro meses, a atividade física prescrita foi caminhada com a orientação e acompanhamento profissional, com uma duração média de 45 minutos e frequência de três vezes por semana, totalizando 49 treinos no período. A participante contou com a orientação e acompanhamento nutricional individual durante todo o período de intervenção, contando com avaliação inicial e retorno periódico para adequações da dieta. Foram avaliados no início e quatro meses após: frequência cárdica (FC) e pressão arterial (PA) em repouso, índice de massa corporal (IMC), índice cintura/quadril (ICQ), percentual de gordura corporal (%GC), percentual de massa muscular (%MM), VO2máx e exames bioquímicos. Resultados: A participante apresentou as seguintes mudanças: aumento da PA de repouso, do %MM e do VO2máx; redução da FC de repouso, do IMC, do ICQ, do %GC, e em todos os exames bioquímicos. Conclusão: Diante dos resultados podemos afirmar que uma ação conjunta, exercício físico e alimentação, somado a disciplina e regularidade do participante, são capazes de afetar positivamente os índices de saúde avaliados.
An Investigation of CO2-Responsive Preformed Particle Gel for Conformance Control of CO2 Flooding in Reservoirs With Fractures or Fracture-Like Channels
Authors: Wang Ze , Bai Baojun , Long Yifu , Wang Lizhu 
Published: August 2019

Summary
Gel treatment is an important technique to solve early CO2 breakthrough and excess–CO2–production problems, caused by the low viscosity and low density of CO2, as well as the heterogeneity of reservoirs with fractures or fracture–like channels. However, there is no reported work on gel that increases its volume after reacting with CO2 (termed CO2–responsive gel) for the conformance control of CO2 flooding. In this paper, the intrinsic properties of a CO2–responsive preformed particle gel (CR–PPG) were evaluated in a water/supercritical–CO2 (scCO2) environment in high–pressure vessels. Continuous scCO2 injection and CR–PPG treatment were conducted in fractured sandstone cores, to probe their plugging performance to scCO2 flow in a high–permeability–contrast system. The volumetric swelling ratio (VSR) of the CR–PPG increased by approximately two times in the presence of scCO2, compared with a sample under similar conditions in the absence of scCO2. The CR–PPG swelling ratio decreased with increasing NaCl concentration. Under the same conditions, the temperature did not have an apparent effect on the swelling ratio after 31 days of swelling. In coreflooding experiments, the placed CR–PPG resisted a considerable pressure up to 617.0 psi before breakthrough. After a shut–in process, CO2–breakthrough pressure was detected at 437.2 psi. It is observed that the shut–in process improved the plugging performance of CR–PPG to CO2 as revealed by the increase in the residual resistance factor. Controlling the shut–in time was found to be effective in augmenting the increase in the residual resistance factor, by increasing the VSR of placed CR–PPG. Resistance of CR–PPG to some real field challenges, including a high pressure gradient and long–term exposure to CO2, was also reported for field–applicability concerns.
Raising the Bar of Productivity Improvement in an Abnormal and Distinctive Pressure and Temperature Environment: Niger Delta.
Authors: Imbazi Oyeintonbra , Ugoh Oluwatobi , Okoloma Emmanuel , Osuagwu Micheal , Enyioko Chigoziem , Ighavini Emmanuel , Uzodinma Chioma 
Published: August 2019

Abstract
Well 01 and Well 02 are part of the phase 1-6 project that involved the development of six wells with the potential to deliver an additional 70% production increase to the LNG export market. The sand face for both wells was drilled with 0.72psi/ft pseudo oil-based mud (POBM). After the initial well clean-up, both wells produced sub-optimally (~20% of estimated potential) with relatively high drawdown (ranging from 500psi – 1000psi). This low production was suspected to be because of downhole (screen and formation) impairment or partial opening of the formation isolation valves (FIV).
A restoration team was set up with a responsibility to proffer a robust well intervention execution plan and select the most potent barite dissolver. Nine stimulation chemicals were tested and based on the team criteria, CHEM-001 and CHEM-002 were selected as main-treatment and pre-flush chemicals, respectively.
The downhole and surface conditions that exist in deep high-pressure wells pose many challenges to the coiled tubing industry as it strives to provide safe and reliable access to the wells. This paper highlights a case history of successfully snubbing coiled tubing (CT) into two deep (about 14,000ft+) live wells (Well 01 and Well 02) with a high surface pressure (7000psi+) and temperature (80 – 100°C) to stimulate both wells. The success criteria post stimulation was targeted at 75% of the potential production value. However, post treatment results show that cumulative gas production increased by 375% (with about 200psi) with a potential to increase up to 400%.
This paper details the entire operations during the CT well intervention, the planning, design, and technical analysis which led to the selection of a CT with 130,000psi yield strength on a 125K CT injector system, force simulations, and laboratory tests on CT with stimulation chemicals which led to a successful stimulation campaign. The paper also covers the initial planned versus actual operations and the lessons learned leading to on-the-spot optimization plans that resulted in a highly successful intervention operation.
Continuum of Sexual and Gender-Based Violence risks among Syrian Refugee Women and Girls in Lebanon
Authors: Roupetz Sophie , Stephanie Garbern , Saja Michael , Harveen Bergquist , Heide Glaesmer , Susan Bartels 
Published: August 2019

Abstract
Background: A myriad of factors including socio-economic hardships impact refugees, with females being additionally exposed to various forms of sexual and gender-based violence (SGBV). For instance, sexual exploitation and forced prostitution can become negative coping mechanisms through which some women and girls raise funds to cover their families’ living expenses. The aim of this qualitative analysis was to understand and to provide new insight into the experiences of SGBV among Syrian refugee women and girls in Lebanon.
Methods: The data are gained from a larger mixed-methods study, investigating the experiences of Syrian refugee girls in Lebanon, using an iPad and the data collection tool, SenseMaker®. The SenseMaker survey intentionally did not ask direct questions about experiences of SGBV but instead enabled stories about SGBV to become apparent from a wide range of subjects of the daily lives of Syrian girls. For this analysis, all first-person stories by female respondents were screened and those about experiences of SGBV were included in a thematic analysis. To present men’s perceptions on these experiences, a random selection of stories about Syrian girls in Lebanon from male respondents was analyzed.
Results: In total, 70 of the 327 first person stories from female respondents and 42 of the 159 male stories, included dialogue on SGBV. While experiences of sexual harassment were mainly reported by women and girls, male respondents were much more likely to talk explicitly about sexual exploitation. Due to different forms of SGBV risks in public, unmarried girls were at high risk of child marriage, whereas married girls more often experienced some form of IPV and/or DV. In abusive relationships, some girls and women continued to face violence as they sought divorces and attempted to flee unhealthy situations.
Conclusions: Our findings shed light on the importance of recognizing the impact of SGBV on the family as a whole in addition to each of the individual members and to consider the cycle of SGBV not only across the woman’s lifespan but also across generations. The identified gendered differences in how SGBV was discussed may have implications for the design of future research focused on SGBV.