bluuebunny/crossref_metadata_2025_split huggingface dataset:
First genetic characterisation and phylogenetic position of Aplectana hylambatis (Nematoda: Cosmocercidae), infecting Pithecopus azureus (Anura: Hylidae) in the Brazilian Pantanal
Authors: dos Santos P.S. , Silva I.C.O. , Ferreira V.L. , Tavares L.E.R. , Paiva F. , Pereira F. B. 
Published: October 2024

Abstract
Aplectana hylambatis (Baylis, 1927) is a widespread nematode in South America that infects different species of anurans from different families. Although the morphology of this species shows intraspecific variations and is well studied, A. hylambatis does not have genetic characterisation. Therefore, the present study aimed to provide the first genetic characterisation of this parasite, based on 18S and 28S rDNA sequences, as well as to evaluate its phylogenetic position in the family Cosmocercidae. The present specimens showed no major morphological variations and were assigned to A. hylambatis mainly based on the shape of spicules and the presence of mamelon-like structures slightly anterior to the vulva. The genetic characterisation confirmed the close relationship between A. hylambatis and other cosmocercids, and the 28S sequences were more informative for phylogenetic reconstruction, especially for those relationships at higher and intermediate levels. Aplectana hylmabatis was in a basal position within a clade formed by other congeners and species of Cosmocerca. The geographic origin may have influence in the divergence process of Aplectana spp. and genus was non-monophyletic and closely related to Cosmocerca, similar to previous findings. The present results will be useful for future studies on the phylogeny of Cosmocercidae, since several genera and species in this family still lack genetic characterisation. Furthermore, the 28S sequences can be useful in genetic studies of A. hylambatis populations, since this species appears to have phenotypic variations.
An interview with Richard Swinburne
Authors: Baker-Hytch Max 
Published: October 2024

Abstract
This article is part of Religious Studies’ new initiative to publish a series of interviews with distinguished philosophers of religion. Each interview explores the personal and academic background of the interviewee and discusses their core philosophical views. The aim is to inspire students and scholars and to provide an overview of some of the most important works developed by contemporary philosophers of religion. In the first interview, Max Baker-Hytch interviews Richard Swinburne, covering such topics as his upbringing, his days as a student in Oxford in the 1950s, and his views on natural theology, the problem of evil, and the mind-body problem.
A brotherhood of nations: Imagining the nation-based order during the Springtime of Nations (1848)
Authors: Duhé Arthur 
Published: October 2024

Abstract
Much like nations, the nation-based order and the domestic and international hierarchies it produces are imagined. Benedict Anderson and scholars in Historical International Relations have frequently approached nationalism and nations as a horizontal division of the world. By contrast, this article explores the imagined hierarchies within and between nations during the 1848 Springtime of Nations. Through an examination of fraternal images found in a variety of textual and visual sources, I investigate how the European national imaginary of 1848 translated into the nation-based order and its corresponding domestic and international hierarchies. The collapse of the 1848 Revolutions brought about a crisis in the national imaginary. The revolutionary fraternity was co-opted in a distorted form by dynastic regimes and opposed by socialists advocating for the international brotherhood of workers. The Springtime of Nations, with its successes and failures, was a pivotal chapter in creating, shaping, legitimising, and challenging the nascent nation-based order.
Robot skill acquisition for precision assembly of flexible flat cable with force control
Authors: Song Xiaogang , Xu Peng , Xu Wenfu , Li Bing , Qin Lei 
Published: October 2024

AbstractThe flexible flat cable (FFC) assembly task is a prime challenge in electronic manufacturing. Its characteristics of being prone to deformation under external force, tiny assembly tolerance, and fragility impede the application of robotic assembly in this field. To achieve reliable and stable robotic automation assembly of FFC, an efficient assembly skill acquisition strategy is presented by combining a parallel robot skill learning algorithm with adaptive impedance control. The parallel robot skill learning algorithm is proposed to enhance the efficiency of FFC assembly skill acquisition, which reduces the risk of damaging FFC and tackles the uncertain influence resulting from deformation during the assembly process. Moreover, FFC assembly is also a complex contact-rich manipulation task. An adaptive impedance controller is designed to implement force tracking during the assembly process without precise environment information, and the stability is also analyzed based on the Lyapunov function. Experiments of FFC assembly are conducted to illustrate the efficiency of the proposed method. The experimental results demonstrate that the proposed method is robust and efficient.
Task design, L1 literacy, and second language oracy
Authors: Ryan Jonathon , Foster Pauline , Wang Yi , Fester Anthea , Yap Jia Rong 
Published: October 2024

AbstractThis paper reports a replication of part of Tavakoli and Foster’s (2008) investigation into the influence of narrative task design on second language (L2) oral performance. The initial study found in part that narratives with both foreground and background information elicited significantly greater syntactic complexity than those with only foreground information. This close replication adds the variable of literacy, conducting the study with adult refugees to New Zealand with low first language (L1) literacy. Participants narrated two of the four cartoon strips in Tavakoli and Foster (2008). In contrast to the initial study, background information in the narrative tasks had no impact on the syntactic complexity, lexical diversity, or fluency of performances. However, given the tendency of participants to omit background events, this outcome is discussed in terms of visual literacy, and aptness to describe rather than connect the cartoon frames. The implications for the use of narrative tasks with such learners are explored.
Water scarcity and consumer behavior: an analysis of diet-related water footprint
Authors: Frola Enrica Nadia , Cavaliere Alessia , De Marchi Elisa , D'Alessandro Felice , Benfenati Alessandro , Aletti Giacomo , Banterle Alessandro 
Published: October 2024

Abstract
Within the framework of an increasing water scarcity, fostered by the climate change, in this study we investigate the environmental impact associated with current food consumption by means of the Water footprint indicator focusing on the case of Italy. For the analysis of the real food consumption and its impact, we selected the Mediterranean diet as a benchmark, since previous evidence shows that Italians are shifting their dietary habits away from the traditional Mediterranean Diet in favor of dietary patterns rich in animal-based products, especially meat. To promote more sustainable food choices, we applied a Sustainable Diet Model to analyze alternative diets that can reduce the Water footprint associated with food consumption. The results of the analysis show that by adopting slight changes in the consumption of certain categories of foods, it is possible to reduce the Water footprint of diets. The findings of this research are useful for supporting policies for the promotion of sustainable food consumption that would lead to a reduction in the exploitation of a scarce resource such as water, improving the allocation of this resource and achieving the objectives of the 2030 Agenda.
A microsystem for in vivo wireless monitoring of plastic biliary stents using magnetoelastic sensors
Authors: Nambisan Ramprasad M. , Green Scott R. , Kwon Richard S. , Elta Grace H. , Gianchandani Yogesh B. 
Published: October 2024

AbstractWith an interest in monitoring the patency of stents that are used to treat strictures in the bile duct, this paper reports the investigation of a wireless sensing system to interrogate a microsensor integrated into the stent. The microsensor is comprised of a 28-μm-thick magnetoelastic foil with 8.25-mm length and 1-mm width. Magnetic biasing is provided by permanent magnets attached to the foil. These elements are incorporated into a customized 3D polymeric package. The system electromagnetically excites the magnetoelastic resonant sensor and measures the resulting signal. Through shifts in resonant frequency and quality factor, the sensor is intended to provide an early indication of sludge accumulation in the stent. This work focuses on challenges associated with sensor miniaturization and placement, wireless range, drive signal feedthrough, and clinical use. A swine specimen in vivo experiment is described. Following endoscopic implantation of the sensor enabled plastic stent into the bile duct, at a range of approximately 17 cm, the signal-to-noise ratio of ~106 was observed with an interrogation time of 336 s. These are the first reported signals from a passive wireless magnetoelastic sensor implanted in a live animal.
Tumor-targeted glutathione oxidation catalysis with ruthenium nanoreactors against hypoxic osteosarcoma
Authors: Zhang Hanchen , Montesdeoca Nicolás , Tang Dongsheng , Liang Ganghao , Cui Minhui , Xu Chun , Servos Lisa-Marie , Bing Tiejun , Papadopoulos Zisis , Shen Meifang , Xiao Haihua , Yu Yingjie , Karges Johannes 
Published: October 2024

AbstractThe majority of anticancer agents have a reduced or even complete loss of a therapeutic effect within hypoxic tumors. To overcome this limitation, research efforts have been devoted to the development of therapeutic agents with biological mechanisms of action that are independent of the oxygen concentration. Here we show the design, synthesis, and biological evaluation of the incorporation of a ruthenium (Ru) catalyst into polymeric nanoreactors for hypoxic anticancer therapy. The nanoreactors can catalyze the oxidation of glutathione (GSH) to glutathione disulfide (GSSG) in hypoxic cancer cells. This initiates the buildup of reactive oxygen species (ROS) and lipid peroxides, leading to the demise of cancer cells. It also stimulates the overexpression of the transient receptor potential melastatin 2 (TRPM2) ion channels, triggering macrophage activation, leading to a systemic immune response. Upon intravenous injection, the nanoreactors can systemically activate the immune system, and nearly fully eradicate an aggressive osteosarcoma tumor inside a mouse model.
Regulatory review of benefits and risks of preventing infant RSV disease through maternal immunization
Authors: Hong-Nguyen Yugenia K. , Toerner Joseph , Lee Lucia , Allende Maria C. , Kaslow David C. 
Published: October 2024

AbstractIn August 2023, FDA approved Abrysvo for active immunization of pregnant individuals at 32 through 36 weeks gestational age to prevent lower respiratory tract disease (LRTD), including severe LRTD, caused by respiratory syncytial virus (RSV) in infants from birth through 6 months of age. A pragmatic approach to narrow the interval of use of Abrysvo in pregnant individuals balanced benefits of vaccine effectiveness against potential risks to infant and mother.
Chromosome-scale genome assembly of the mangrove climber species Dalbergia candenatensis
Authors: Shi Miaomiao , Zhang Yu , Huang Huiwen , Gu Shiran , Wang Xiangping , Li Shijin , Zhao Zhongtao , Tu Tieyao 
Published: October 2024

AbstractConsisting of trees, climbers and herbs exclusively in the intertidal environments, mangrove forest is one of the most extreme and vulnerable ecosystems of our planet and has long been of great interest for biologists and ecologists. Here, we first assembled the chromosome-scale genome of a climber mangrove plant, Dalbergia candenatensis. The assembled genome size is approximately 474.55 Mb, with a scaffold N50 of 48.1 Mb, a complete BUSCO score of 98.4%, and a high LTR Assembly Index value of 21. The genome contained 283.46 Mb (59.74%) repetitive sequences, and 29,554 protein-coding genes were predicted, of which 87.54% were functionally annotated in five databases. The high-quality genome assembly and annotation presented herein provide a valuable genomic resource that will expedite genomic and evolutionary studies of mangrove plants and facilitate the elucidation of molecular mechanisms underlying the salt- and water-logging-tolerance of mangrove plants.
Spatial selective auditory attention is preserved in older age but is degraded by peripheral hearing loss
Authors: Caso Andrea , Griffiths Timothy D. , Holmes Emma 
Published: October 2024

AbstractInterest in how ageing affects attention is long-standing, although interactions between sensory and attentional processing in older age are not fully understood. Here, we examined interactions between peripheral hearing and selective attention in a spatialised cocktail party listening paradigm, in which three talkers spoke different sentences simultaneously and participants were asked to report the sentence spoken by a talker at a particular location. By comparing a sample of older (N = 61; age = 55–80 years) and younger (N = 58; age = 18–35 years) adults, we show that, as a group, older adults benefit as much as younger adults from preparatory spatial attention. Although, for older adults, this benefit significantly reduces with greater age-related hearing loss. These results demonstrate that older adults with excellent hearing retain the ability to direct spatial selective attention, but this ability deteriorates, in a graded manner, with age-related hearing loss. Thus, reductions in spatial selective attention likely contribute to difficulties communicating in social settings for older adults with age-related hearing loss. Overall, these findings demonstrate a relationship between mild perceptual decline and attention in older age.
Long-term snow-track indices of a Finnish native mesopredator declined while those of an invasive one increased
Authors: Selonen Vesa , Toivonen Pyry , Lindén Andreas 
Published: October 2024

AbstractMonitoring both native and invasive species is crucial for understanding their ecological impacts. However, obtaining reliable data can be challenging, especially for elusive species like mesopredators. This study utilized snow-track surveys in Finland (1989–2022) to examine population trends of the invasive raccoon dog and the native red fox. While raccoon dogs are known to reduce activity during cold weather, we demonstrated that accounting for temperature and snowfall allows for effective population trend estimation using snow-track data. Track accumulation decreased in cold and snowy weather more clearly for raccoon dogs than for red foxes. We also found that the track accumulation of the raccoon dog had significantly increased, while those of the red fox population had declined, particularly in southern parts of the country. Notably, raccoon dog snow-track numbers increased in northern regions, suggesting a potential for further range expansion under a warming climate. These findings reveal a concerning shift in Finland’s mesopredators abundance due to the invasive species’ success and the decline of the native species. Thus, the invasive raccoon dog is likely to have an increasing role in those northern ecosystems where it interacts with the native fauna.
Single-nucleus RNA-seq dissection of choroid plexus tumor cell heterogeneity
Authors: Hill Anthony D , Okonechnikov Konstantin , Herr Marla K , Thomas Christian , Thongjuea Supat , Hasselblatt Martin , Patrizi Annarita 
Published: October 2024

AbstractThe genomic, genetic and cellular events regulating the onset, growth and survival of rare, choroid plexus neoplasms remain poorly understood. Here, we examine the heterogeneity of human choroid plexus tumors by single-nucleus transcriptome analysis of 23,906 cells from four disease-free choroid plexus and eleven choroid plexus tumors. The resulting expression atlas profiles cellular and transcriptional diversity, copy number alterations, and cell–cell interaction networks in normal and cancerous choroid plexus. In choroid plexus tumor epithelial cells, we observe transcriptional changes that correlate with genome-wide methylation profiles. We further characterize tumor type-specific stromal microenvironments that include altered macrophage and mesenchymal cell states, as well as changes in extracellular matrix components. This first single-cell dataset resource from such scarce samples should be valuable for divising therapies against these little-studied neoplasms.
Eicosapentaenoic acid induces macrophage Mox polarization to prevent diabetic cardiomyopathy
Authors: Li Jie , Nan Wenshan , Huang Xiaoli , Meng Huali , Wang Shue , Zheng Yan , Li Ying , Li Hui , Zhang Zhiyue , Du Lei , Yin Xiao , Wu Hao 
Published: October 2024

AbstractDiabetic cardiomyopathy (DC) leads to heart failure, with few effective approaches for its intervention. Eicosapentaenoic acid (EPA) is an essential nutrient that benefits the cardiovascular system, but its effect on DC remains unknown. Here, we report that EPA protects against DC in streptozotocin and high-fat diet-induced diabetic mice, with an emphasis on the reduction of cardiac M1-polarized macrophages. In vitro, EPA abrogates cardiomyocyte injury induced by M1-polarized macrophages, switching macrophage phenotype from M1 to Mox, but not M2, polarization. Moreover, macrophage Mox polarization combats M1-polarized macrophage-induced cardiomyocyte injury. Further, heme oxygenase 1 (HO-1) was identified to maintain the Mox phenotype, mediating EPA suppression of macrophage M1 polarization and the consequential cardiomyocyte injury. Mechanistic studies reveal that G-protein-coupled receptor 120 mediates the upregulation of HO-1 by EPA. Notably, EPA promotes Mox polarization in monocyte-derived macrophages from diabetic patients. The current study provides EPA and macrophage Mox polarization as novel strategies for DC intervention.
Evaluation of E-Cigarette Use in Opioid-Dependent Patients in
Maintenance Treatment
Authors: Rabl Josef , Specka Michael , Bonnet Udo , Irtürk Özge , Schifano Fabrizio , Scherbaum Norbert 
Published: October 2024

Abstract
Introduction As tobacco smoking decreases, the use of e-cigarettes is on
the rise. There is a debate whether switching from smoking to the use of
e-cigarettes might represent a harm reduction strategy for those who smoke
tobacco heavily, a habit often observed in individuals with opioid dependence.
The present study investigated the prevalence and patterns of tobacco smoking
and e-cigarette use in patients in opioid maintenance treatment (OMT) and
whether e-cigarette use contributed to the cessation of smoking tobacco.
Methods In 2014 (n=84) and in 2021 (n=128), patients from two OMT clinics
of a psychiatric university hospital were interviewed
Results In both surveys, patients presented with a comparable average age
(45.6 vs. 46.9 years of age), gender distribution (mainly male 71.4 vs. 75.8%),
and length of OMT history (median: 66 vs. 55 months). The lifetime prevalence of
e-cigarette use (45.2% in 2014 and 38.3% in 2021) was much higher than the
current prevalence (4.9% and 7.8%, respectively). Few patients reported either a
complete switch from smoking to the use of e-cigarettes (2014, n=1 vs. 2021,
n=2) or the achievement of abstinence from smoking after a temporary use of
e-cigarettes (2014, n=2 vs. 2021, n=1).
Discussion No increase in the use of e-cigarettes was observed in these
groups of patients undergoing OMT. Presumably, harm reduction strategies
relating to the use of e-cigarettes in this group need to be supported by
motivational interventions. Given the high morbidity and mortality due to
smoking, OMT clinics should offer professional help in reducing smoking.
Current State and Outlook in Medical 3D Printing and the Role of Radiology
Authors: Streckenbach Anna , Schubert Niklas , Streckenbach Felix , Dust Tobias , Ngo Ngoc Tuan , Fiehler Jens , Munz Martin , Hueners Ida , Schneider Philipp , Frenzel Thorsten , Gargioni Elisabetta , Wegner Marie , Chin Shih-Jan , Well Lennart , Adam Gerhard , Meyer Mathias 
Published: October 2024

AbstractMedical three-dimensional (3D) printing is playing an increasingly important role in clinical practice. The use of 3D printed models in patient care offers a wide range of possibilities in terms of personalized medicine, training and education of medical professionals, and communication with patients. DICOM files from imaging modalities such as CT and MRI provide the basis for the majority of the 3D models in medicine. The image acquisition, processing, and interpretation of these lies within the responsibility of radiology, which can therefore play a key role in the application and further development of 3D printing.The purpose of this review article is to provide an overview of the principles of 3D printing in medicine and summarize its most important clinical applications. It highlights the role of radiology as central to developing and administering 3D models in everyday clinical practice.This is a narrative review article on medical 3D printing that incorporates expert opinions based on the current literature and practices from our own medical centers.While the use of 3D printing is becoming increasingly established in many medical specialties in Germany and is finding its way into everyday clinical practice, centralized “3D printing labs” are a rarity in Germany but can be found internationally. These labs are usually managed by radiology departments, as radiology is a connecting discipline that – thanks to the imaging technology used to produce data for 3D printing – can play a leading role in the application of medical 3D printing. Copying this approach should be discussed in Germany in order to efficiently use the necessary resources and promote research and development in the future.
Histopathological Findings of Epithelial Invasion after Arcuate and Radial Keratotomies
Authors: Serfözö Alexandra , Flockerzi Fidelis , Berger Tim , Quintin Adrien , Seitz Berthold 
Published: October 2024

Abstract
Background Complications after arcuate (АKs) and radial keratotomies (RKs) may include infection, delayed wound healing, and epithelial invasion.
Purpose To assess the histopathologic findings of epithelial invasion following АK/RK.
Methods The study included patients who underwent penetrating keratoplasty (PK) after previous АK or RK treatment. In corneas with histologically confirmed epithelial invasion, the following parameters were examined: invasion depth (µm), width (µm) in the superficial, middle, and deep stroma, and the ratio of invasion depth to corneal thickness. The time between АK/RK and PK was compared for corneas with and without detectable epithelial invasion.
Results Out of 31 excised corneas, 7 (22%) showed epithelial invasion 2 to 19 years (median 6 years) after АK/RK. Histological examination revealed different invasion patterns, with a mean depth of 315 (231 to 395) µm or 57% (46 to 66%) of corneal thickness. The mean width in the superficial stroma was 291 (75 to 789) µm, in the middle stroma 210 (33 to 422) µm, and in the deep stroma 164 (19 to 324) µm. No significant association was found between the presence of the epithelial invasion and the time after PK (p = 0.83).
Conclusion In almost a quarter of the eyes after АK or RK, epithelial invasion could be detected. The potential biomechanical instability associated with this should be considered in cases of trauma as well as in the context of planning cataract surgery or PK, particularly in the hands of less experienced surgeons. Nonmechanical contact-free excimer laser trephination may be helpful in PK.