bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prevalence of adult epilepsy in a general Japanese population: The Hisayama study
Authors: Tanaka Akihiro , Hata Jun , Akamatsu Naoki , Mukai Naoko , Hirakawa Yoichiro , Yoshida Daigo , Kishimoto Hiro , Ohara Tomoyuki , Mizuno Toshiki , Tsuji Sadatoshi , Kitazono Takanari , Ninomiya Toshiharu 
Published: December 2018

SummaryThe aim of the present study was to examine the prevalence and causes of adult epilepsy in a general Japanese population. We examined a total of 3333 Japanese residents in the town of Hisayama aged ≥40 years in 2012‐2013. The examination was performed mainly at the municipal center for health promotion, but some subjects were examined in their homes, hospitals, or nursing homes. Twenty‐three subjects had a diagnosis of epilepsy. The prevalence (95% confidence interval [CI]) of epilepsy per 1000 was 6.9 (4.1‐9.7) in total, 4.9 (1.3‐8.5) in men, and 8.4 (4.3‐12.5) in women (P = 0.23 between sexes). The prevalence of epilepsy was significantly higher in the elderly (aged ≥65 years; 10.3 per 1000 [95% CI 5.4‐15.1]) than in the middle‐aged (aged 40‐64 years; 3.6 per 1000 [95% CI 0.7‐6.4]; P = 0.02). The major cause of epilepsy was cerebrovascular diseases (n = 11; 48% of the epilepsy patients). More than half of the epilepsy patients experienced the first episode of seizure in older age (≥65 years; n = 13; 57%). The findings of this study suggest the clinical importance of the prevention of cerebrovascular diseases to reduce the burden of epilepsy in the future.
Dibromometallyl‐iron complexes generated by the recombination of an alumanyl‐iron complex with EBr3 (E = Al, Ga)
Authors: Yanagisawa Tatsuya , Mizuhata Yoshiyuki , Tokitoh Norihiro 
Published: December 2018

AbstractThe first dibromoalumanyl‐iron complex [Br2Al–FeCp(CO)2] was synthesized by the reaction of monobromoalumanyl‐iron complex bearing a bulky substituent on aluminum atom with AlBr3, whose structure was determined by the X‐ray crystallographic analysis and the NMR measurement. The reactions monobromoalumanyl‐iron complex with GaBr3 show that these reactions would proceed by the mutual recombination of substituents.
Failure patterns of head and neck squamous cell carcinoma treated with radical radiotherapy by intensity modulated radiotherapy technique using focal volume and dosimetric method
Authors: Tandon Sarthak , Gairola Munish , Ahlawat Parveen , Karimi Ahmad Masroor , Tiwari Sandeep , Muttagi Vinayakumar , Sachdeva Nishtha , Sharief Muhammed Ismail , Dobriyal Kiran 
Published: December 2018

AbstractBackgroundLabeling locoregional failures in head and neck cancer (HNC) as “local” and “regional” becomes incomplete when treating with intensity modulated radiotherapy (IMRT). Target delineation and delivery errors, dose in‐homogeneity complicate the assessment of failures. A combination of focal point and dosimetric method might attempt at simplifying failure analysis.MethodsOne hundred eleven patients with locally advanced HNC treated with chemoradiation using IMRT were enrolled. Patients with documented failure had their recurrence volume assessed using focal point and dosimetric method.ResultsWith a median follow‐up of 20 (range 0‐39) months and median locoregional control (LRC) of 30 (range 24.8‐34.5) months, the patients had a 3‐year overall survival and LRC of 70.6% and 48.9%, respectively. Of 39 failures, there were 69.2%, 7.6%, 5.1%, 12.8%, and 5.1% type A, B, C, D, and E, respectively using the focal point and dosimetric method.ConclusionWith the current classification, majority of the recurrences were high dose failures suggesting inherent radioresistance. While minority of failures were potentially preventable and needed modifying existing IMRT workflow.
Carotid body tumor with hidden internal carotid artery aneurysm
Authors: Rohlfing Matthew L. , Yang Betty , Jalisi Scharukh 
Published: December 2018

AbstractBackgroundThe most common head and neck paraganglioma is the carotid body paraganglioma. Treatment of carotid body tumors is primarily surgical, and uncontrolled growth leads to cranial nerve deficits and more morbid resection.MethodsA 60‐year‐old man was referred for evaluation of carotid body tumor, and workup revealed an internal carotid artery (ICA) aneurysm within the known mass.ResultsInterventional Radiology performed angiogram and stenting across aneurysm with interval dramatic reduction in size of mass, and surgery was avoided altogether.ConclusionsSurgical resection is indicated for carotid body paragangliomas when the patient can tolerate the surgery and when the tumor was not very advanced. This patient had a small tumor that initially appeared easily resectable. Failure to detect the ICA aneurysm before resection may have resulted in devastating vascular injury and possible stroke or death. Identification of underlying vascular pathology is essential for safe treatment and should be prioritized, especially considering this case.
Retracted: Epigallocatechin gallate ameliorates morphological changes of pancreatic islets in diabetic mice and downregulates blood sugar level by inhibiting the accumulation of AGE‐RAGE
Authors: Feng Zhongtao , Hou Xiumei , Zhu Chuanan , Zhu Jiabin , Jiang Chunxiao 
Published: December 2018

AbstractThis study aimed to elucidate the key mechanisms and effects of the functional component of green tea, epigallocatechin gallate (EGCG) on a diabetic mouse model. The detected relationship between compounds and genes recorded in the STITCH database highlighted an interaction network between the direct target genes of EGCG and the known diabetes‐related genes, which was made apparent through the analysis of gene‐gene interactions and signaling pathways, revealing that a key AGE‐RAGE signaling pathway in diabetes was enriched in the network. By means of systematic supplementary analyses on diabetic mice, provided evidence suggested that EGCG could significantly enhance the morphology of pancreatic tissues in diabetic mice and downregulate the blood glucose level in a clear dose effect manner, and increased insulin receptor (IR), insulin receptor substrate (IRS1 and IRS2) expression in the liver. Through the detection of protein expression, EGCG was observed to possess the ability to downregulate the accumulation of AGE‐RAGE in pancreatic tissues as well as in the transcription factor nuclear factor‐κB (NF‐κB), which represents a potentially significant method by which EGCG influences diabetes. The results of this study provided evidence indicating that EGCG can effectively improve the morphology of pancreatic tissues, but notably reduce blood glucose levels in diabetic mice, which may be related to its inhibition of AGE‐RAGE signaling pathway and activation of transcription factor NF‐κB pathway.
A 4‐gene prognostic signature predicting survival in hepatocellular carcinoma
Authors: Chen Peng‐Fei , Li Qing‐He , Zeng Li‐Rong , Yang Xue‐Ying , Peng Pai‐Lan , He Jian‐Hua , Fan Bin 
Published: December 2018

AbstractObjectiveTo develop an independent prognostic signature for patients with hepatocellular carcinoma (HCC).MethodsHCC gene expression profile the cancer genome atlas‐liver hepatocellular carcinoma and GSE14520 were used as discovery and test set, respectively. Differentially expressed genes (DEGs) were identified between HCC tissues and adjacent normal liver tissues. Univariate Cox proportional hazards regression analysis was performed to identify DEGs correlated with survival of HCC patients. A 4‐gene‐based signature was constructed based on a least absolute shrinkage and selection operator Cox penalized regression model. The predictive value of the signature was analyzed and validated.ResultsTwo hundred sixty‐three DEGs were identified between HCC and adjacent liver tissues. After univariate survival analysis, 90 DEGs were found to be significantly correlated with the overall survival (OS) of HCC patients, of which 4 genes (KPNA2, CDC20, SPP1, and TOP2A) with non‐zero coefficient were used to construct a prognostic signature. The 4‐gene signature was significantly associated with the age (P = 0.046), grade (
P = 0.022), and T stage (
P = 0.023) of HCC patients in the discovery set and it also significantly associated with TNM stage (
P = 0.033), and serum alpha‐fetoprotein lever (
P = 0.034). Patients in the 4‐gene low‐risk group were associated with better OS and recurrence‐free survival (RFS) than those in the high‐risk group in the discovery and test set. Meanwhile, the 4‐gene signature is an independent prognostic factor regarding OS and RFS in the discovery and test set.ConclusionWe developed a 4‐gene‐based signature, which could be a candidate prognostic factor for patients with HCC.
Inhibition of microRNA‐132 attenuates inflammatory response and detrusor fibrosis in rats with interstitial cystitis via the JAK‐STAT signaling pathway
Authors: Song Ya‐Jun , Cao Jun‐Ying , Jin Zhuang , Hu Wen‐Gang , Wu Rong‐Hua , Tian Lu‐Hai , Yang Bo , Wang Jin , Xiao Ya , Huang Chi‐Bing 
Published: December 2018

AbstractInterstitial cystitis (IC) is a heterogeneous syndrome with unknown etiology, and microRNAs (miRs) were found to be involved in IC. In our study, we aim to explore the role of miR‐132 in the inflammatory response and detrusor fibrosis in IC through the Janus kinase‐signal transducer and activator of transcription (JAK‐STAT) signaling pathway in rat models. A rat model of IC was established and treated with the miR‐132 mimic, miR‐132 inhibitor, and/or JAK‐STAT signaling pathway inhibitor AG490. Enzyme‐linked immunosorbent assay was applied to measure the expression of interleukin (IL)‐6, IL‐10, interferon‐γ (IFN‐γ), and tumor necrosis factor‐α (TNF‐α), and intercellular adhesion molecule‐1 (ICAM‐1). The urodynamic test was performed to assess urodynamic parameters, and reverse transcription quantitative polymerase chain reaction and Western blot analysis for the expression of miR‐132, STAT4, suppressors of cytokine signaling 3 (SOCS3), JAK2, vascular endothelial growth factor (VEGF), IFN‐γ, and TNF‐α. IC rats treated with miR‐132 inhibitor and AG490 had decreased collagen fiber, inflammatory cell infiltration, and mast cells, lower expression of IL‐6, IL‐10, IFN‐γ, TNF‐α, ICAM‐1, collagens I and III, and alleviated urodynamic parameters and decreased expression of STAT4, VEGF, JAK2, IFN‐γ, TNF‐α, and increased expression of SOCS3. Taken together, our data indicate that downregulation of miR‐132 alleviates inflammatory response and detrusor fibrosis in IC via the inhibition of the JAK‐STAT signaling pathway.
Upregulation of stanniocalcin‐1 inhibits the development of osteoarthritis by inhibiting survival and inflammation of fibroblast‐like synovial cells
Authors: Wu Ying , Li Zhengcai , Jia Wenji , Li Mai , Tang Mei 
Published: December 2018

AbstractObjectiveOsteoarthritis (OA) is a progressive and disabling disorder, characterized by synovial inflammation and joint effusion. This study aimed to explore the role of stanniocalcin‐1 (STC1) in the development of OA by regulating the survival and inflammation of fibroblast‐like synovial (FLS) cells.MethodsMicroarray analyses were adopted to screen differentially expressed genes (DEGs) related to OA, and regulatory microRNA (miR) was also identified. Synovial tissue samples from patients with OA and healthy individuals were obtained to determine the expression levels of miR‐454, STC1, IL‐6, IL‐8, and MMP3/13. The targeted relationship between miR‐454 and STC1 was verified by dual‐luciferase reporter gene assay. With the treatment of miR‐454 mimic and STC1 overexpression vector, the effect of miR‐454 and STC1 on FLS cell viability and apoptosis as well as production of inflammatory cytokines were tested.ResultsSTC1 with aberrant low expression was screened from GSE1919 profile in OA. STC1 was found to be downregulated in OA‐FLS tissues and cells. STC1 overexpression inhibited OA‐FLS cell viability but induced apoptosis of OA‐FLS cells. Moreover, STC1 overexpression decreased levels of IL‐6, IL‐8, and MMP3/13, suggesting that STC1 overexpression suppressed inflammatory reactions. In addition, miR‐454 blocked the inhibitory effects of STC1 overexpression on OA‐FLS cell viability and inflammatory reaction and exerted a promotion effect of STC1 overexpression on apoptosis of OA‐FLS cells.ConclusionsTaken together, the results revealed that upregulation of STC1 could repress proliferation of OA‐FLS cells and inflammatory reaction, and enhance apoptosis of OA‐FLS cells, which was negatively regulated by miR‐454.
miR‐93‐5p may be an important oncogene in prostate cancer by bioinformatics analysis
Authors: Yang Yuemei , Jia Binghan , Zhao Xiaoling , Wang Yao , Ye Weiliang 
Published: December 2018

AbstractIntroductionProstate adenocarcinoma is one of the most prevalent causes of cancer‐related deaths in males worldwide. However, the underlying mechanisms remain poorly understood. Hence, it is important to identify specific and effective therapeutic targets, to be able to determine appropriate therapy and management. So, this study aimed to predict that miR‐93‐5p is an important oncogene in prostate cancer by bioinformatics analysis.MethodsIn this study, initially we identified differentially expressed genes (DEGs) and differently expressed miRNAs (DEMs) in the The Cancer Genome Atlas (TCGA) database, performed Gene Ontology (GO) and pathway enrichment analysis, then investigated the relationship between DEGs and DEMs, and finally through consulting the literature and retrieving the database, we found that miR‐93‐5p may play a major role in prostate cancer, so we predicted the expression and survival of miR‐93‐5p and its isomers by bioinformatics analysis, meanwhile, evaluated the function of miR‐93‐5p in vitro.ResultsIn total, 104 DEMs were differently expressed between prostate cancer and normal samples, including 56 downregulated ones and 48 upregulated ones; miR‐93‐5p (upregulated) was identified as a good biomarker. And 1904 DEGs were retrieved, including 794 downregulated ones and 1110 upregulated ones. We also obtained 1254 DEGs of the DEMs. In GO and Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis, the significantly enriched pathways involved pathway in focal adhesion, vascular smooth muscle contraction, and regulation of actin cytoskeleton. By the KEGG pathway, we got 16 target genes and 92 pathways of the miR‐93‐5p in prostate cancer. We also found that the miR‐93‐5p and its isomers can express in prostate cancer, and which with a high expression had a poor overall survival and a significant difference recurrence rate within 5 years. Further in vitro verification results demonstrated that the low expression of miR‐93‐5p can inhibit cell proliferation, migration, invasion, change cell cycle, and promote early apoptosis of PC‐3 cells.ConclusionThe miR‐93‐5p and its target genes were used to define important molecular targets that could serve as a prognostic and predictive marker in the treatment of prostate cancer. Further research on the function of the miR‐93‐5p and its target genes in the KEGG pathway could provide references for the treatment of prostate cancer.
Triples of orthogonal Latin and Youden rectangles for small orders
Authors: Jäger Gerold , Markström Klas , Öhman Lars‐Daniel , Shcherbak Denys 
Published: December 2018

AbstractWe have performed a complete enumeration of nonisotopic triples of mutually orthogonalLatin rectangles for. Here we will present a census of such triples, classified by various properties, including the order of the autotopism group of the triple. As part of this, we have also achieved the first enumeration of pairwise orthogonal triples of Youden rectangles. We have also studied orthogonal triples ofrectangles which are formed by extending mutually orthogonal triples with nontrivial autotopisms one row at a time, and requiring that the autotopism group is nontrivial in each step. This class includes a triple coming from the projective plane of order 8. Here we find a remarkably symmetrical pair of triples ofrectangles, formed by juxtaposing two selected copies of complete sets of mutually orthogonal Latin squares of order 4.
Compliance with preoperative care measures reduces surgical site infection after colorectal operation
Authors: Guzman‐Pruneda Francisco A. , Husain Syed G. , Jones Christian D. , Beal Eliza W. , Porter Erica , Grove Michele , Moffatt‐Bruce Susan , Schmidt Carl R. 
Published: December 2018

BackgroundSurgical site infections (SSIs) are a major cause of morbidity complicating colorectal operations. Several evidence‐based preoperative strategies are associated with decreased SSI rates. We hypothesize that compliance with multiple strategies is associated with lower incidence of SSI after the elective colorectal operation.MethodsPreoperative care measure compliance before colorectal operations were assessed. Measures included antiseptic wash the night before and day of operation, oral antibiotic, and mechanical bowel preparation, antibiotic prophylaxis, Chloraprep skin preparation, and hair clipping. Rates of SSI after colectomy and other pertinent outcomes were stratified by full and partial compliance with preoperative measures. Exclusion criteria included bowel perforation, ischemia, complete obstruction, intra‐abdominal abscess, and no intraoperative skin closure.ResultsEight hundred twenty‐six subjects underwent colectomy between 2010 and 2016; 469 met inclusion criteria. Compliance with all measures occurred in 214 (46%) and was independently associated with lower postoperative infection rates (odds ratio [OR], 0.37; confidence interval [CI], 0.16‐0.85; P = 0.02). SSI occurred in 51 (11%): was superficial in 35 (7%); deep in 5 (1%); and organ space in 11 (2%). SSI rates were reduced from 16% (partial or no compliance group) to 5% (full compliance group). No stand‐alone intervention was independently associated with decreased SSI rate. Multivariate analysis found the following factors associated with a lower risk of SSI: full compliance with all five process measures, lower BMI, nonsmoker, and minimally invasive operation.Discussion and ConclusionCompliance with preoperative care strategies reduces rates of SSI after colectomy with a cumulative effect more pronounced than any single intervention reinforcing the need for protocol‐driven and evidence‐based care for patients undergoing colorectal operations.
Prospective study on image‐guided navigation surgery for pelvic malignancies
Authors: Nijkamp Jasper , Kuhlmann Koert F. D. , Ivashchenko Oleksandra , Pouw Bas , Hoetjes Nikie , Lindenberg Melanie A. , Aalbers Arend G. J. , Beets Geerard L. , van Coevorden Frits , KoK Niels , Ruers Theo J. M. 
Published: December 2018

Background and objectivesSurgery of advanced tumors and lymph nodes in the pelvis can be challenging due to the narrow pelvic space and vital surrounding structures. This study explores the application of a novel electromagnetic navigation system to guide pelvic surgery.MethodsThis was a prospective study on surgery for malignancies in the pelvis. Preoperatively obtained imaging was used to create a patient‐specific three‐dimensional (3D) roadmap. In the operating room, the 3D roadmap was registered to an intraoperative computed tomography scan. A tracked pointer was used during surgery for guidance. Primary endpoint was safety and feasibility, secondary endpoints were accuracy and usability.ResultsTwenty‐eight colorectal, four liposarcomas, and one gynecological patient were included. There were no safety issues. Navigation was feasible in 31 patients. The mean target registration errors of 4.0 and 6.3 mm were achieved for straight and French position, respectively. In seven of seven patients with a locally advanced rectal tumor and in seven of eight patients with recurrences, negative margins were achieved. Thirty‐three of 36 target lymph nodes were successfully removed. Surgeons using the system indicated faster localization of the tumor and improved decisiveness.ConclusionThis novel surgical navigation system was safe and feasible during pelvic surgery and can facilitate its users.
Overall survival of patients with colon cancer and a prolonged time to surgery
Authors: Lino‐Silva Leonardo S. , Guzmán‐López Janet C. , Zepeda‐Najar César , Salcedo‐Hernández Rosa A. , Meneses‐García Abelardo 
Published: December 2018

BackgroundFactors associated with the time to surgery (TTS) and survival in colon cancer (CC) have not been well studied. Our aim was to find if the TTS has changed in our institution over time and to determine if it influences the survival.MethodsRetrospective cross‐section study of 266 CC analyzed between two periods, and according to the quartiles of TTS, we performed a survival analysis.ResultsThe median age was 57 years; there was no predominance of sex, and about half of the patients were in stage III. The median TTS was 38 days, and 75% of the cases were operated before 60 days. The median TTS for 2005 to 2010 was 36 days, while for 2011 to 2015 was 41 days (P = 0.107). The survival was not statistically different between cases (1) operated with a delayed TTS or not, (2) operated in four cut‐off points of TTS, (3) two different periods of attention, and (4) according to the clinical stage.ConclusionWe did not find an association between the TTS with low survival. TTS has increased in the last period so we must work to make the diagnostic process more efficient in our patients to meet international quality standards.
Revision surgery following minimally invasive image‐guided cochlear implantation
Authors: Morrel William G. , Jayawardena Asitha D. L. , M. Amberg Susan , Dawant Benoit M. , Noble Jack H. , Labadie Robert F. 
Published: December 2018

Minimally invasive image‐guided cochlear implantation (CI) research continues to progress. We previously performed the procedure in nine patients. Herein, we describe the first revision operation for device failure following minimally invasive image‐guided CI. It was possible to reuse the original drill channel, obviating the need to convert to a wide‐field mastoidectomy. Revision surgery, if required, can therefore be performed safely after minimally invasive image‐guided CI.Level of EvidenceNALaryngoscope, 129:1458–1461, 2019
Is greater antibiotic therapy prior to ESS associated with differences in surgical outcomes in CRS?
Authors: Ramakrishnan Vijay R. , Mace Jess C. , Soler Zachary M. , Smith Timothy L. 
Published: December 2018

ObjectiveAntibiotics have been a mainstay of chronic rhinosinusitis therapy; however, data suggest that antibiotics may also result in several adverse unintended consequences. We aimed to evaluate if greater antibiotic use prior to sinus surgery was associated with differences in surgical outcomes.MethodsAdult CRS patients enrolled in a prospective, multi‐institutional, observational cohort study were asked to recall systemic antibiotic use in the 90 days prior to endoscopic sinus surgery (ESS). Antibiotic use was examined in relation to demographics, disease characteristics, and outcomes.ResultsData were collected for 271 study participants followed for a mean of 14.9 [± 5.1] months across four institutions, with a mean preoperative antibiotic use of 27.8 [± 22.7] days out of the 90 preceding ESS. After ESS, significant improvement (P < 0.001) was reported for patient‐reported outcome measures and endoscopy scores for the overall cohort. No bivariate correlation between preoperative antibiotic use and degree of benefit in objective clinical measures (endoscopy, Brief Smell Identification Test) was seen. Increased preoperative antibiotic use was associated with less improvement in 22‐item SinoNasal Outcome Test (SNOT‐22) and its rhinologic subdomain after ESS. Prevalence of achieving a minimal clinically important difference in overall SNOT‐22 symptom scores was lower in those using more preoperative antibiotics, although statistical significance was not reached when adjusting for independent covariates in multivariate modeling.ConclusionHigher amounts of previous antibiotic use do not appear to be associated with better ESS outcomes. Specific recommendations for antibiotic use as part of CRS‐appropriate medical therapy prior to ESS require further study, particularly given concerns for antibiotic overuse and implications for improving outcomes in the modern healthcare era.Level of Evidence2C Laryngoscope, 129:558–566, 2019