bluuebunny/crossref_metadata_2025_split huggingface dataset:
Implementation of an experimental isolated lung perfusion model on surgically resected human lobes
Authors: Slama Alexis , Raber Christian , Hedderich Celia , Stockhammer Paul , Hegedüs Balazs , Koch Achim , Theegarten Dirk , Ploenes Till , Aigner Clemens 
Published: August 2019

AbstractIsolated lung perfusion (ILP) is an ideal model to study treatment effects on a variety of pathologies. As published research mostly relies on rejected donor lungs or animal organs, this study investigates the use of surgically resected human lobes as an alternative and novel model for personalized experimental research. Ten surgically resected lobes were perfused in acellular and normothermic condition. The indication for surgery was lung cancer. Perfusion and ventilation were adapted to the size of the lobes and both functional and metabolic parameters were assessed during ILP. Patients (age 67.5 y (59–81)|♀n = 3|♂n = 7) underwent anatomic pulmonary lobectomy. Ischemic time between arterial ligation and ILP was 226 minutes (161–525). Median duration of ILP was 135 (87–366) minutes. Gas exchange and mechanical respiratory parameters remained steady during ILP (pulmonary venous pO2 196(151–219) mmHg | peak AWP: 14.5(11–22) cmH2O). Metabolism stayed constant during ILP (Glucose consumption: 1.86 mg/min/LTLC (95%CI: −2.09 to −1.63) | lactate production: 0.005 mmol/min/ LTLC (95%CI: 0.004 to 0.007)). ILP of surgically resected human lobes is a feasible and promising method. By maintaining a near physiological setting, this model may pave the way for future experimental lung research including cancer research, transplantation, physiology, pharmacology and mechanical ventilation.
Development of a Reproducible Prognostic Gene Signature to Predict the Clinical Outcome in Patients with Diffuse Large B-Cell Lymphoma
Authors: Zamani-Ahmadmahmudi Mohamad , Nassiri Seyed Mahdi 
Published: August 2019

AbstractAlongside various clinical prognostic factors for diffuse large B-cell lymphoma (DLBCL) such as the international prognostic index (IPI) components (ie, age, tumor stage, performance status, serum lactate dehydrogenase concentration, and number of extranodal sites), prognostic gene signatures have recently shown promising efficacy. However, previously developed signatures for DLBCL suffer from many major inadequacies such as lack of reproducibility in external datasets, high number of members (genes) in a signature, and inconsistent association with the survival time in various datasets. Accordingly, we sought to find a reproducible prognostic gene signature with a minimal number of genes. Seven datasets—namely GSE10856 (420 samples), GSE31312 (470 samples), GSE69051 (157 samples), GSE32918 (172 samples), GSE4475 (123 samples), GSE11318 (203 samples), and GSE34171 (91 samples)—were employed. The datasets were randomly categorized into training (1219 samples comprising GSE10856, GSE31312, GSE69051, and GSE32918) and validation (417 samples consisting of GSE4475, GSE11318, and GSE34171) groups. Through the univariate Cox proportional hazards analysis, common genes associated with the overall survival time with a P value less than 0.001 and a false discovery rate less than 5% were identified in 1219 patients included in the 4 training datasets. Thereafter, the common genes were entered into a multivariate Cox proportional hazards analysis encompassing the common genes and the international prognostic index (IPI) factors as covariates, and then only common genes with a significant level of difference (P < 0.01 and z-score >2 or <−2) were selected to reconstruct the prognostic signature. After the analyses, a 7-gene prognostic signature was developed, which efficiently predicted the survival time in the training dataset (Ps < 0.0001). Subsequently, this signature was tested in 3 validation datasets. Our signature was able to strongly predict clinical outcomes in the validation datasets (Ps < 0.0001). In the multivariate Cox analysis, our outcome predictor was independent of the routine IPI components in both training datasets (Ps < 0.0001). Furthermore, our outcome predictor was the most powerful independent prognostic variable (Ps < 0.0001). We developed a potential reproducible prognostic gene signature which was able to robustly discriminate low-risk patients with DLBCL from high-risk ones.
A novel noninvasive method for remote heart failure monitoring: the EuleriAn video Magnification apPLications In heart Failure studY (AMPLIFY)
Authors: Abnousi Freddy , Kang Guson , Giacomini John , Yeung Alan , Zarafshar Shirin , Vesom Nicholas , Ashley Euan , Harrington Robert , Yong Celina 
Published: August 2019

AbstractCurrent remote monitoring devices for heart failure have been shown to reduce hospitalizations but are invasive and costly; accurate non-invasive options remain limited. The EuleriAn Video Magnification ApPLications In Heart Failure StudY (AMPLIFY) pilot aimed to evaluate the accuracy of a novel noninvasive method that uses Eulerian video magnification. Video recordings were performed on the neck veins of 50 patients who were scheduled for right heart catheterization at the Palo Alto VA Medical Center. The recorded jugular venous pulsations were then enhanced by applying Eulerian phase-based motion magnification. Assessment of jugular venous pressure was compared across three categories: (1) physicians who performed bedside exams, (2) physicians who reviewed both the amplified and unamplified videos, and (3) direct invasive measurement of right atrial pressure from right heart catheterization. Motion magnification reduced inaccuracy of the clinician assessment of central venous pressure compared to the gold standard of right heart catheterization (mean discrepancy of −0.80 cm H2O; 95% CI −2.189 to 0.612, p = 0.27) when compared to both unamplified video (−1.84 cm H2O; 95% CI −3.22 to −0.46, p = 0.0096) and the bedside exam (−2.90 cm H2O; 95% CI −4.33 to 1.40, p = 0.0002). Major categorical disagreements with right heart catheterization were significantly reduced with motion magnification (12%) when compared to unamplified video (25%) or the bedside exam (27%). This novel method of assessing jugular venous pressure improves the accuracy of the clinical exam and may enable accurate remote monitoring of heart failure patients with minimal patient risk.
CHANG-ES
Authors: Mora-Partiarroyo Silvia Carolina , Krause Marita , Basu Aritra , Beck Rainer , Wiegert Theresa , Irwin Judith , Henriksen Richard , Stein Yelena , Vargas Carlos J. , Heesen Volker , Walterbos René A. M. , Rand Richard J. , Heald George , Li Jiangtao , Kamieneski Patrick , English Jayanne 
Published: August 2019

Aims. NGC 4631 is an interacting galaxy which exhibits one of the largest gaseous halos observed among edge-on galaxies. We aim to examine the synchrotron and polarization properties of its disk and halo emission with new radio continuum data.
Methods. Radio continuum observations of NGC 4631 were performed with the Karl G. Jansky Very Large Array at C-band (5.99 GHz) in the C and D array configurations, and at L-band (1.57 GHz) in the B, C, and D array configurations. The Rotation Measure Synthesis algorithm was utilized to derive the polarization properties.
Results. We detected linearly polarized emission at C-band and L-band. The magnetic field in the halo is characterized by strong vertical components above and below the central region of the galaxy. The magnetic field in the disk is only clearly seen in the eastern side of NGC 4631, where it is parallel to the plane of the major axis of the galaxy. We detected for the first time a large-scale, smooth Faraday depth pattern in a halo of an external spiral galaxy, which implies the existence of a regular (coherent) magnetic field. A quasi-periodic pattern in Faraday depth with field reversals was found in the northern halo of the galaxy.
Conclusions. The field reversals in the northern halo of NGC 4631, together with the observed polarization angles, indicate giant magnetic ropes with alternating directions. To our knowledge, this is the first time such reversals are observed in an external galaxy.
Geburt eines Fohlens nach Besamung mit tiefgefrorenen
Nebenhodenspermien und zeitgleicher intrauteriner Verabreichung von homologem
Seminalplasma
Authors: Neuhauser Stefanie , Gösele Patricia , Handler Johannes 
Published: August 2019

ZusammenfassungDie Tiefgefrierkonservierung von Nebenhodenspermien stellt eine gute Möglichkeit
zur Erhaltung der Genreserve wertvoller Vatertiere dar, wenn ein plötzlicher
Unfall eine herkömmliche Samengewinnung unmöglich macht. Im vorliegenden Fall
wird von der Geburt eines gesunden Fohlens berichtet, das aus der Besamung mit
Nebenhodenspermien entstand. Die Hoden und Nebenhoden wurden in
Allgemeinanästhesie entfernt und gekühlt über Nacht in das Labor verbracht.
Durch retrograde Spülung der Nebenhodenschwänze konnten 17,79 × 109
Spermien konserviert werden. Eine fruchtbare Stute wurde 1 Jahr später mit
tiefgefrorenen Nebenhodenspermien tief intrauterin besamt. Im 1. Zyklus wurde
die Stute nicht tragend. Im 2. Zyklus wurde homologes Seminalplasma zusammen mit
den Nebenhodenspermien in den Uterus verbracht und 14 Tage nach der Ovulation
konnte eine Trächtigkeit festgestellt werden. Nach einer Graviditätsdauer von
334 Tagen wurde ein gesundes Hengstfohlen geboren. Die Vorbereitung von Hoden
und Nebenhoden nach einem Unfall oder Todesfall für die weitere Bearbeitung im
Labor und die einzelnen Arbeitsschritte für die Aufbereitung von
Nebenhodenspermien werden beschrieben.
Eccentric-concentric Ratio: A Key Factor for Defining Strength Training in Soccer
Authors: Nuñez F. Javier , Hoyo Moisés de , López Alejandro Muñoz , Sañudo Borja , Otero-Esquina Carlos , Sanchez Hugo , Gonzalo-Skok Oliver 
Published: August 2019

AbstractThe aims of this study were to analyse the effect of chronic strength training over concentric power (CON), eccentric power (ECC), ECC/CON ratio, and 20 m linear sprint performance in elite young soccer players. Twenty young elite Spanish soccer players were assigned to an experimental group (CPG) which performed a front-step exercise using a conical pulley, 2–3 sets of 6 repetitions each leg, during 9 weeks (CPG, n=10) in addition to its usual strength training, or to a control group (CG, n=10). The improvements in the ECC mean power (36%, ES=1.61), and ECC / CON ratio (17%, ES=1.77) were substantially greater in the CPG than in the CG while the CON mean power (16%, ES=0.83) was substantially greater in the CG than in the CPG. The sprinting time for 10 m (2.8%, ES=0.78) and the 10 m flying time between 10–20 m (1.72%, ES=0.41) were substantially enhanced in CPG and CG respectively. To be efficient when defining a functional strength training and performance increments using an inertial device, the mean power output need to be measured during the CON and ECC phases and an analysis of the ECC / CON ratio should be included.
Preparation of the Serotonin Transporter PET Radiotracer 2-({2-[(Dimethylamino)methyl]phenyl}thio)-5-[18F]fluoroaniline (4-[18F]ADAM): Probing Synthetic and Radiosynthetic Methods
Authors: Milicevic Sephton Selena , Zhou Xiaoyun , Thompson Stephen , Aigbirhio Franklin I. 
Published: August 2019

Serotonin transporters (SERTs) are involved in regulating the concentration of synaptic serotonin and present a good target for many neurologic and psychiatric disorder drugs. Positron-emission tomography (PET) is a valuable tool in both diagnosis and monitoring treatment therapies, and hence much effort is being given to developing suitable PET agents for imaging SERT. Our interest in applying the fluorine-18 analogue 4-[18F]ADAM for imaging SERT prompted the development of an improved synthetic route to access unlabelled ADAM. This is achieved using Pd-catalysed coupling with thiosalicylic acid and an EDC/HOBt amide coupling in 36% yield over 4 steps. A novel radiolabelling precursor, the pinacol-derived boronic ester, is prepared from the bromide using the Miyaura borylation and is obtained in 27% yield over 6 steps. Pinacolate is then used for the radiolabelling of 4-[18F]ADAM based on Cu-mediated nucleophilic fluorination in which the presence of oxygen is critical for the reaction. A 1:1 substrate to copper ratio is found to be optimal when the reaction is performed in dimethylacetamide at 85 °C. Using these conditions, 4-[18F]ADAM is prepared in 29 ± 10% (n = 6) radiochemical conversion after hydrolysis of the Boc group with HCl. Furthermore, the method is successfully automated to afford 4-[18F]ADAM in 10% radiochemical conversion.
Fragmented QRS and QRS Duration As a Marker of Myocardial Reperfusion Measured by Myocardial Blush Grade in Reperfusion Therapy: Systematic Review and Meta-Analysis
Authors: Pranata Raymond , Yonas Emir , Chintya Veresa , Alkatiri Amir Aziz 
Published: August 2019

Myocardial blush grade (MBG) is an indicator of microvascular perfusion and patency and an independent predictor of cardiac outcomes. QRS duration and fragmented QRS (fQRS) before reperfusion and its changes after reperfusion are shown to be associated with MBG. We aimed to assess the latest evidence on the association between fQRS and QRS duration with MBG in reperfusion therapy.We performed a comprehensive search on the association between fQRS and QRS duration in successful/impaired reperfusion measured by MBG.There were a total of 1,311 patients from six studies. A shorter QRS duration immediately and at 60 minutes after reperfusion attempt was associated with successful reperfusion, with a mean difference (MD) of –10.62 ms ([–15.55, –5.70]; p < 0.001; I
2 = 69%) and –15.66 ms ([–19.96, –11.37]; p < 0.001; I
2 = 77%), respectively, and upon sensitivity analysis, with exclusion of a study, heterogeneity decreases to 33 and 0%. QRS narrowing immediately and 60 minutes after reperfusion attempt was correlated with reperfusion, with an MD of –10.72 ([–16.57, –4.88] ; p < 0.001; I
2 = 97%) and –10.93 ([–14.00, –7.85]; p < 0.001; I
2 = 97%), lesser in impaired reperfusion, respectively. QRS duration on admission was not associated with reperfusion outcome. Two studies reported that fQRS was associated with impaired perfusion, with an odds ratio of 9.88 ([5.62–17.38]; p < 0.0001) and 4.74 ([2.45–9.20]; p < 0.0001), respectively.A longer QRS duration immediately and at 60 minutes after reperfusion attempt was associated with impaired perfusion. QRS narrowing after reperfusion attempt was correlated with successful reperfusion. fQRS was also associated with a higher probability of impaired perfusion.
Kinematically Aligned TKA Aligns the Ankle Joint Line Closer to Those of the Native Ankle than Mechanically Aligned TKA in Bipedal Stance
Authors: Kim Jung-Taek , Han Jun , Lim Sumin , Shen Quan Hu , Won Ye Yeon 
Published: August 2019

AbstractMechanically aligned total knee arthroplasty (MATKA) aims to make alignment of the hip, knee, and ankle straight unexceptionally. However, emerging evidence suggests that unexceptional straightening the mechanical axis of the lower limb may lead to clinical and radiological problems of the ankle joint. By contrast, kinematically aligned total knee arthroplasty (KATKA) strives to restore the articular surface of the prearthritic knee. In this study, we examined results from KATKA and MATKA to determine which surgery restores the ankle joint orientation closer to the native ankle joint in bipedal stance and hypothesized that KATKA, rather than MATKA, would be more effective. Data from long-leg standing radiographs of 60 healthy adults (control group, n = 120 knees), patients who underwent MATKA (n = 90 knees), and patients who underwent KATKA (n = 90 knees) were retrospectively reviewed. The hip–knee–ankle angle, orientation of the tibial plafond and the talar dome relative to the ground (G-plafond and G-talus, respectively), and orientation of the plafond relative to the mechanical axis of the limb (M-plafond and M-talus, respectively) were measured and analyzed for comparison. Results show that bipedal stance alignment in patients who underwent KATKA (G-plafond: −0.65 ± 3.03 and G-talus: −1.72 ± 4.02) were not significantly different to native ankle joint alignment indicated by the control group. Compared with the native ankle joint measured in the control group (G-plafond: −0.76 ± 2.69 and G-talus: −1.30 ± 3.25), the tibial plafond and talar dome significantly tilted laterally relative to the ground in ankle joints after MATKA (G-plafond: −2.32 ± 3.30 and G-talus: −2.97 ± 3.98, p = 0.001 and p = 0.004, respectively). Thus, postoperative ankle joint line orientation after KATKA was horizontal to the floor and closer to that of native ankle joints than those after MATKA. The level of evidence is Level III.
Patch Test Results and Outcome in Patients with Complications from Total Knee Arthroplasty: A Consecutive Case Series
Authors: Sasseville Denis , Alfalah Khuzama , Savin Evgeny 
Published: August 2019

AbstractThe role of hypersensitivity in implant-related complications remains controversial. The objectives of our study were to (1) establish the prevalence of hypersensitivity to components of knee prostheses in patients referred to our contact dermatitis clinic, (2) determine if patients with post-surgery dermatitis have become sensitized, and (3) describe the outcome of patients with and without hypersensitivity. We reviewed the charts of patients referred from 2007 to 2018 and extracted demographic information, date, type, and site of implant, clinical presentation, and results of patch testing (PT) or lymphocyte transformation tests (LTT). We called most patients to gather data such as clinical outcome, nature, and timing of additional surgery. Statistical analysis included computation of conventional descriptive statistics. Because of the type of study design, only some categorical variables were tested for possible associations by analytical tools (cross-tabulation). Thirty-nine patients, 23 men (59.0%), and 16 women (41.0%), were included. Their mean age in years was 63.3 (95% confidence interval [CI]: 60.9–65.7) ranging from 39.0 to 79.0, (standard deviation) = 9.69, without statistically significant differences between males and females. Five patients had positive PT possibly relevant to their implant. Four patients had revision surgery and two improved. Of nine patients with dermatitis, one with relevant PT did not improve after revision, and the dermatitis was unrelated to TKA in eight. Of the 26 patients without dermatitis or relevant PT results, 9 had revisions because of incapacitating symptoms, and 5 improved. Hypersensitivity to implant components is a potential factor in the etiology of TKA complications. Patients with confirmed hypersensitivity may benefit from revision. Our study, however, did not detect statistically significant differences in outcome of revision surgery between patients with positive versus negative PT or LTT. In spite of this, we consider that patients with a history suggestive of metal, acrylate or aminoglycoside allergy should be tested preoperatively to avoid hypersensitivity-related postoperative complications. In the absence of hypersensitivity, some patients with incapacitating symptoms may also improve following revision.
Evaluation of Knee Cartilage Diurnal, Activity, and BMI-Related Variations Using Quantitative T2 Mapping MRI and Fitbit Activity Tracking
Authors: Matcuk George R. , Jones Ian A. , McIntyre J. Alex , Burt Robert , Hwang Darryl , Cen Steven , Schein Aaron J. , Vangsness C. Thomas 
Published: August 2019

AbstractThe aim of this study is to evaluate diurnal variation in knee cartilage 3 Tesla magnetic resonance imaging (MRI) T2 mapping relaxation times, as well as activity- and body mass index (BMI)-dependent variability, using quantitative analysis of T2 values from segmented regions of the weight-bearing articular surfaces of the medial and lateral femoral condyles and tibial plateaus. Ten healthy volunteers' daily activity (steps) were tracked with Fitbit pedometers. Sagittal MRI T2 maps were obtained in the morning and afternoon on days 2 and 3. Mean T2 values were analyzed for variation related to the number of steps taken (activity), time of day (diurnal variation), and BMI using mixed effect model. Significant (albeit small) differences in the medial femoral and medial tibial cartilage regions were identified between morning and afternoon scans (diurnal variation). Daily activity did not result in significant changes and increasing BMI only demonstrated a slight increase in T2 values for the lateral tibial plateau. These findings suggest that it may be necessary to control diurnal variation when using quantitative MRI T2 mapping to assess articular cartilage longitudinally in healthy participants. Further investigation is needed to confirm these findings and determine if they also apply to symptomatic patients.
Methodology to evaluate the placement of wind turbine based on GIS technology
Authors: Vaysman Ya I , Surkov A A , Surkova Yu I , Vlasov A S , Kychkin A V 
Published: August 2019

Abstract
The paper is devoted to the development of a methodology to evaluate the possible locations of wind generators using GIS technologies for the climatic conditions of the Western Urals. A model of the wind generator operation in the electrical network using the OpenModelica simulation environment has been built. Recommendations on the use of a wind generator and a feasibility study of its use on the base of an energy-efficient autonomous research module (EEARM) are worked out.
Human capital for sustainable development: a comparative analysis of regions of the Republic of Kazakhstan
Authors: Panzabekova A , Satybaldin A , Alibekova G , Abilkayir N 
Published: August 2019

Abstract
Human capital is the primary base for sustainable development at both macro, middle, and micro levels. The purpose of this study is the preliminary clustering of the regions of Kazakhstan according to human capital factors as public health and environmental issues. The results are intermediate and are subject to further study.
Probing DNA nucleobases with diamond (111) surfaces
Authors: Putra Miftahussurur Hamidi , Fyta Maria 
Published: August 2019

AbstractDNA units, the nucleobases, are probed with diamond (111) surfaces. The nucleobases are placed on top of a diamond surface interacting in a very specific way with the surface atoms. Different elements, such as hydrogen, nitrogen, and fluorine are chosen for the termination of the diamond. The energetic features and electronic properties of the combined system ’nucleobase/diamond surface’ are thoroughly studied using quantum-mechanical calculations. These point to nucleobase- and termination-specific characteristics linking to the potential of using diamond surfaces for identifying the DNA nucleobases. Focus is further given on mixed surfaces with a varying nitrogen and hydrogen coverage. For these, we provide pathways for tuning the electronic band gap of the surface/nucleobase complex with the nitrogen content of the surface. The results could unravel a clear crossover in the surface electron affinity and its relation to a reversal in the positions of the electronic band extremes from the material to the molecule and vice versa. These features link to a further selective modulation of the electronic transport and the excitation properties of the complexes with a strong biosensing potential.