bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Anti-Proliferative Activity of Anisosciadone: A New Guaiane Sesquiterpene from Anisosciadium lanatum
Authors: Mahmoud Ahmed A. , El-Sayed Wael M. 
Published: March 2019

Background:The increase in cancer rate and the development of resistant tumors require a continuous search for new anticancer agents.Aims:This study aimed to analyze and identify the chemical constituents of Anisosciadium lanatum, and to investigate the antiproliferative activity of the identified constituents against various human cell lines (HepG2, MCF7, HT29, A549, and PC3) along with the possible molecular mechanisms involved.Methods:The structure of the isolated compounds was determined by spectroscopic techniques including HRFABMS, GC-MS, IR, and 400 MHz 1D and 2D NMR analyses (1H, 13C NMR, DEPT, 1H-1H COSY, HMQC, HMBC and NOESY). The antiproliferative activity and IC50 value of the isolated compounds were measured and compared to doxorubicin.Results:A new guaiane sesquiterpene containing a rare epoxide structural element, 10β,11β−epoxy−1α,4β,5β,7αΗ- guaiane-9-one, anisosciadone (1), and stigmasterol (2) have been isolated from the plant. Anisosciadone (1) showed a significant antiproliferative activity against liver, colon, and lung cells only, while stigmasterol (2) had a significant activity against liver, colon, and breast cells. Both 1 and 2 caused no cytotoxicity to normal fibroblasts. Anisosciadone elevated the expression and activity of Caspase 3 as well as p53 expression without affecting Caspase 9 in HepG2 cells. It also caused ~ 50% downregulation in cdk1 expression.Conclusion:Taken together, anisosciadone was specific in action against cancer cells and induced apoptosis in liver cells. It also has a unique feature by elevating the expression and activity of Caspase 3 without affecting the initiator Caspase 9. Therefore, anisosciadone deserves more investigation as a targeted therapy for cancer.
Key Mechanisms of the Seismic Behaviour of External RC Wide Beam–column Joints
Authors: Santarsiero Giuseppe , Masi Angelo 
Published: March 2019

Background:
Reinforced concrete beam-column connections provided with wide beams are widely used in the European residential building stock. Several seismic codes indicate some limitation to be applied to this kind of reinforced concrete buildings due to their reduced performances with respect to those provided with conventional beams.

Objective:
The paper is focused on improving the knowledge of wide beam-column joints, highlighting the key degradation mechanisms affecting them, mainly related to slip phenomena of beam rebars, especially the rebars placed outside the column width.

Methods:
The behavior of wide beam-column joints has been evaluated by means of both experimental tests under cyclic loading and accurate nonlinear finite element analyses. The FE models predicted satisfactorily experimental results, thus enabling to carry out additional numerical analyses aimed at checking the effect of the longitudinal reinforcement amount in the beam member.

Results:
Experimental results show that wide beam-column joints conforming to the Italian seismic code do not exhibit a sufficiently ductile behavior due to damage in the non-confined concrete region, where beam rebars external to the joint core are anchored. Numerical simulations allowed to monitor bond slip of beam rebars as a function of the applied global displacement, showing differences between bars placed inside and outside the column width.

Conclusion:
Numerical simulations showed that different behavior is expected in case additional beam rebars are placed either inside or outside column width. In the first case, higher peak load and ductility values can be achieved, provided that the amount of beam reinforcement is not high enough to shift damage towards the column or cause high shear stress to the joint core and its consequent fragile failure.
Kontribusi Pengetahuan Kader Terhadap Kinerja Kader Posyandu di Puskesmas Matandahi Konawe Utara
Authors: Lukwan Lukwan 
Published: March 2019

Abstrak
Salah satu permasalahan Indonesia secara nasional yang berkaitan dengan kader adalah tingginya angka drop out kader.Tiap Posyandu hanya memiliki 2 orang kader yang aktif. Tujuan penelitian ini adalah untuk mengetahui kontribusi pengetahuan terhadap kinerja kader Posyandu. Jenis penelitian yang digunakan adalah penelitian analitik dengan desain Cross Sectional Study dimana pengukuran variabel terikat dan variabel bebas dilakukan pada waktu dan tempat secara bersamaan. Data diolah dengan menggunakan uji statistik SPSS dengan teknik analisis data menggunakan uji Chi square dan uji phi. Hasil uji Chi square diperoleh X2 hit (4,375) dan uji koefisien kontingensi C = (0,474) dengan tingkat kepercayaan 95% (α = 0,05). Nilai X2 hit (4,375) > X2 (3,841), maka Ho ditolak dan Ha diterima. Kesimpulannya adalah ada hubungan yang cukup antara pengetahuan dengan Kinerja kader Posyandu di wilayah kerja Puskesmas Matandahi Kabupaten Konawe Utara.
Kata kunci: Pengetahuan, Kinerja Kader Posyandu
Abstract
Nationally, one of Indonesia’s problems related to the cadres is the high number of drop out cadres. Each Posyandu only has 2 active cadres. The purpose of this study is to know the contribution of knowledge to the performance of Posyandu cadres. The type of research used is analytical research with Cross Sectional Study design where the measurement of dependent variable and independent variable is done at the same time and place. Data were processed by using statistical test of spss with technique of data analysis using chi square test and phi test. Chi square test results obtained X2 hit (4.375) and contingency coefficient test C = (0.474) with 95% confidence level (α = 0.05). X2 hit value (4.375) > X2 (3.841), then Ho is rejected and Ha accepted. The conclusion is that there is a sufficient relationship between knowledge with the performance of Posyandu cadres in the working area of the Puskesmas Matandahi Kabupaten Konawe Utara.
Keywords: Knowledge, Performance of Posyandu Cadre’s
Penelitian Perbedaan Tarif Riil dan INA-CBG’s Penyakit Talasemia di Ruang Perawatan Anak RSUP Sanglah Bali Tahun 2017
Authors: Wijaya Kusuma Anak Agung Made , Ariawati Ketut 
Published: March 2019

Abstrak
Biaya pengobatan suportif seperti transfusi darah dan kelasi besi seumur hidup pada seorang pasien talasemia sangat besar. Hampir seluruh pasien talasemia di RSUP Sanglah Bali merupakan peserta Badan Penyelenggara Jaminan Sosial (BPJS) yang menggunakan sistem pola pembayaran Indonesia Case Based Groups (INA-CBG’s). Penelitian dilakukan untuk mengetahui perbedaan tarif biaya riil dan INA-CBG’s penyakit talasemia di ruang perawatan anak RSUP Sanglah Bali. Penelitian potong lintang menggunakan desain deskriptif, dilakukan pada bulan Januari sampai dengan Desember 2017. Data dalam penelitian ini terdiri dari data karakteristik dan perbedaan antara tarif riil rumah sakit dengan tarif INA-CBGs penyakit talasemia di ruang perawatan anak RSUP Sanglah. Terdapat 313 kasus rawat inap dari 29 pasien talasemia yang diikutsertakan dalam penelitian. Rumah Sakit Umum Pusat Sanglah mendapat nilai positif Rp 534.784.590 (21,8%) dari selisih total tarif paket INA CBG’s dengan total tarif riil rumah sakit pada tahun 2017. Terdapat perbedaan positif antara tarif riil rumah sakit dengan tarif sesuai INA CBG’s pada perawatan anak dengan talasemia di RSUP Sanglah, yang memberi keuntungan bagi pihak rumah sakit.
Kata kunci: talasemia, asuransi, JKN, INA-CBG’s
Abstract
The cost of supportive treatment such as blood transfusion and lifelong iron chelation in thalassemia patient is very expensive. Almost all thalassemia patients at Sanglah Bali Hospital are participants of Badan Penyelenggara Jaminan Sosial (BPJS) who use Indonesia Case Based Groups (INA-CBG’s) payment system. The study was conducted to determine the discrepancy hospital and INA-CBG’s fare of Thalassemia disease at pediatric ward Sanglah Bali Hospital. Cross sectional study using descriptive design, conducted in January until December 2017. The data in this study consisted of data on the characteristics and differences between the hospitals real cost with INA-CBG’s fare in the child with Thalassemia disease at Sanglah Hospital. There were 313 inpatient cases of 29 thalassemia patients enrolled in the study. Sanglah Hospital received a positive value of Rp 534,784,590 (21.8%) from discrepancy of the INA CBG’s fare with the total real cost of hospitals in 2017. There is a positive discrepancy between hospital and INA-CBG’s fare of Thalassemia disease at pediatric ward which gives benefits to the hospital.
Keywords: thalassemia, insurance, JKN, INA-CBG’s
Análisis de vitamina B2 en arroz blanco comercializado en el Área Metropolitana de Cúcuta por cromatografía líquida ultra rápida (UFLC)
Authors: Rodríguez Ordoñez Dora Cecilia , Torres Herrera Laura Natalia 
Published: March 2019

Antecedente: el análisis de riboflavina es uno de los parámetros mayormente referenciado en la determinación del valor nutritivode algunos alimentos. Objetivo: estandarizar el método de análisis y determinar el contenido de riboflavina (vitamina B2) enmuestras de arroz blanco fortificado (A y B) y sin fortificar (C y D), comercializadas en el área metropolitana de Cúcuta.Métodos: la extracción y análisis de dos lotes de cada muestra se realizó por triplicado. Las muestras sin fortificar se doparoncon el fin de determinar el porcentaje de recuperación del método. Tres muestras de 5,0000 gramos de cada lote de arrozfortificado y sin fortificar, fueron sometidas al proceso de extracción de la vitamina mediante hidrólisis ácida, previo tratamientoenzimático con papaína y takadiastasa a 45°C. Los extractos se purificaron filtrando por gravedad con papel filtro, y nuevamentepor filtros de jeringa de celulosa regenerada de 0,20μm. Se determinó por triplicado la concentración de riboflavina en cadaextracto, mediante HPLC en un cromatógrafo líquido UFLC SHIMADZU Prominence. El análisis estadístico de los datos serealizó con el software R versión 3.2.2. Resultados: las concentraciones promedio, en mg de riboflavina/kg de arroz, en lasmuestras de arroz A, B, C y D fueron de 0,4121, 2,3741, 0,3208 y 0,3217, respectivamente para el lote 1 y para el lote 2 de2,3831, 1,0552, 0,4022, y 0,3246, respectivamente. Los porcentajes de recuperación de riboflavina en las muestras dopadasestuvieron alrededor del 91,00%. Conclusiones: se observa que entre diferentes lotes de arroz fortificado de la misma marca sepresenta variación en el contenido de la vitamina. En las muestras de arroz no fortificado, la concentración hallada correspondeal contenido natural de riboflavina en el arroz, con valores muy similares en todas las muestras.
Palabras Claves: Cereales,Fluorescencia,HPLC,Riboflavina,Vitaminas
Bases para la relación investigación - postgrado
Authors: Hernández Dávila Román Antonio , Cerinza-Contento Adriana del Pilar 
Published: March 2019

Antecedentes: la investigación e innovación, son ejes de desarrollo socioeconómico del país. Colombia en las últimas décadas goza de cierto avance en I+D, aunque se requiere en la educación superior una masa crítica que asuma el desafío de la sociedad del conocimiento para enriquecer la relación transformadora entre academia-Estado-desarrollo integral-sociedad. Este artículo presenta una reflexión sobre los conceptos investigación-postgrado (CRES.UNESCO 2008, CESU 2014, COLCIENCIAS 2015), en la intención de lograr el Objetivo de (i) identificar las bases para una relación indisoluble entre ambos, con resultados contundentes en innovaciones, hallazgos científicos e impactos positivos en la calidad de vida y desarrollo sostenible (ii), que agreguen valor al intercambio científico y el diálogo de saberes; y (iii) formule recomendaciones sostenidas en alianzas estratégicas, para crear postgrados pertinentes,redes telemáticas respecto de objetos de estudios compartidos, comunidades de trabajo colaborativo inter y transdisciplinario, crear fuentes múltiples de financiamiento y ampliar grupos, líneas y proyectos de investigación. Desarrollo: el corpus del artículo presenta a las instituciones educativas de educación superior como las principales vitrinas propicias para proponer y mostrar proyectos factibles en investigación, innovación y desarrollo. Conclusiones: la cooperación indisoluble entre postgrados e investigación con criterios de pertinencia, juegan un papel importante para afrontar con propiedad los desafíos establecidos por la sociedad globalizada, en donde las ventajas comparativas entre empresas y países, se encuentran en gestionar con eficiencia el conocimiento que es el capital intangible, motor del valor agregado, movilizador de las economías y del desarrollo sustentable.
Palabras Claves: Instituciones de educación,superior,Investigación,Postgrado,Redes Académicas
Effect of Polymeric Microparticles Loaded With Catechin on the Physicochemical Properties of an Adhesive System
Authors: Albuquerque NLG , Neri J Rabelo , Lemos MVS , Yamauti M , de Sousa FFO , Santiago SL 
Published: March 2019

SUMMARY
The objective of this study was to synthesize and characterize epigallocatechin-3-gallate (EGCG)–loaded/poly(D-L lactide-co-glycolide) acid (PLGA) microparticles, evaluate their effects on degree of conversion and release assay of adhesives, and subsequently to examine the resin-dentin bond strength of two EGCG formulations (free EGCG or loaded into PLGA microparticles) applied as a pretreatment or incorporated into an adhesive system. The formulations were prepared according to a PLGA:EGCG ratio of 16:1 using the spray-drying technique. The size and polydispersity index were determined by light scattering in aqueous dispersion. The degree of conversion (%DC) and release assay were assessed by Fourier transform infrared spectroscopy and ultraviolet-visible spectrophotometer, respectively. Subsequently, 45 third molars were divided into five groups (n=9) according to the different EGCG application modes and prepared for bond strength testing in a universal testing machine. Results demonstrated no statistically significant difference among the DC means after the PLGA microparticles were loaded with EGCG. For the release assay, the 1.0% PLGA/EGCG group presented better results after being elected for use in the bond strength test. The resin-dentin bond strengths of the experimental groups after 12 months of water storage were significantly higher than in the control group. EGCG could improve the durability of the resin-dentin bond over time and promote a new era for adhesive dentistry with the concept of controlled release.
PEMBELAJARAN MAHARAH BAHASA ARAB BERBASIS INKLUSIF
Authors: HARIMI ABDAL CHAQIL 
Published: March 2019

Pembelajaran bahasa pada dasarnya dibuat agar siswa dapat menguasai empat keterampilan bahasa. Keterampilan bahasa tersebut terdiri dari keterampilan mendengar, keterampilan berbicara, keterampilan membaca, dan keterampilan menulis. Oleh karena itu, pembelajaran maharah bahasa Arab harus dilakukan dengan berbagai macam variasi agar tujuan dapat dicapai dengan baik. Hal demikian juga harus dilakukan ketika terdapat peserta didik yang memiliki keterbatasan atau siswa difabel. Demi terwujudnya kelas yang inklusif, seorang guru harus dapat memiliki sifat sensitif agar terciptanya kelas yang berkeadilan bagi mereka.
Artikel ini mencoba untuk memberikan beberapa variasi pembelajaran maharah bahasa Arab bagi siswa-siswa yang memiliki keterbatasan, khususnya adalah siswa tunanetra yang dihasilkan dari beberapa pengalaman penulis dan beberapa kajian teori yang telah ditemukan mengenai pembentukan kelas yang inklusif. Sehingga diharapkan dapat menjadikan kelas lebih mudah untuk dijangkau oleh peserta didik tunanetra.
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Authors: MASPUPAH ULPAH 
Published: March 2019

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GIS Based Flood Flow Assessment in Small Catchments for Flood Mapping in Bosnia and Herzegovina
Authors: Blagojević Borislava , Kovačević Slaven , Nedić Bojana , Lukovac Nijaz , Mujčić Mirza 
Published: March 2019

Abstract
An initial step in flood hazard mapping is hydrological modelling. We present a recent river flood modelling approach in Bosnia and Herzegovina (BiH) for small ungauged catchments of drainage area up to 32 km2. To estimate peak flow of required probability in small catchments, we use the rational method. The paper focus is GIS based procedure for producing the runoff coefficient map for BiH from the DTM and land cover map. For validation of the peak flow modelling results in small ungauged catchments we use diagrams of peak flow per catchment area (specific runoff) versus catchment area in medium and large gauged catchments. The results indicate agreement in specific runoff for 100 and 500 years return period compared to reference runoff in gauged catchments and a mild drop in specific runoff for 20 years.
Experimental investigation of two-phase relative permeability of gas and water for tight gas carbonate under different test conditions
Authors: Wan Teng , Yang Shenglai , Wang Lu , Sun Liting 
Published: March 2019

Currently, tight carbonate gas reservoir has received little attention due to few discoveries of them. In this study, gas–water two-phase relative permeability was measured under two different conditions: High Temperature High Pore Pressure (HTHPP – 80 °C, 38 MPa), as well as Ambient Condition (AC), using whole core samples of tight gas carbonate. Relative permeability curves obtained at HTHPP showed two contrary curve profiles of gas relative permeability, corresponding to the distinctive micro-pore structure acquired from CT-Scanning. Then, based on Klinkenberg theory and a newly developed slip factor model for tight sandstone, slippage effect under AC is calibrated and the overestimation of gas relative permeability prove up to 41.72%–52.34% in an assumed heterogeneity. In addition, relative permeability curves obtained at HTHPP switch to higher gas saturation compared to that under AC with the rock wettability change from water-wet to less water-wet. And the wettability alteration is believed to be caused by charge change on mineral surface.
Anatomical and Visual Outcome of Rhegmatogenous Retinal Detachment Managed with Scleral Buckling at a Tertiary Eye Centre in Nepal
Authors: Rijal Roshija Khanal , Byanju Raghunandan , Pandey Araniko , Mourya Deepesh 
Published: March 2019

Objective: To study the anatomical status and visual outcome of scleral buckling surgery in rhegmatogenous retinal detachment (RRD) at tertiary eye care center in Nepal.
Method: This is a prospective, noncomparative, consecutive, interventional study of rhegmatogenous retinal detachment managed with scleral buckling surgery performed in Lumbini Eye Institute, Nepal. All the patients underwent surgery by a single experienced surgeon and had at least 3 months follow up.
Result: A total of 50 patients (50 eyes) were operated, 38 males and 12 females, with a mean age of 39.46. Retinal reattachment was achieved in 46 (92%). Improved best corrected visual acuity (BCVA) was seen in 84%, whereas in 8% BCVA was same and deteriorated in another 8%.
Conclusion: Rhegmatogenous retinal detachment is one of the common causes of visual impairment and blindness. Timely surgical management with scleral buckling surgery can give good anatomical and visual outcome.
A Case of Descemet’s Membrane Endothelial Keratoplasty in a failed Penetrating Keratoplasty
Authors: Singh Sanjay Kumar , Yadav Reena , Sharma Ashmita 
Published: March 2019

Background: Descemet’s membrane endothelial keratoplasty (DMEK) is an evolving option for failed penetrating keratoplasty (PK) as it has shown promising results compared to repeat PK.
Case description: A 22 years young gentleman presented with gradual diminution of vision in the left eye (LE) for six months following therapeutic PK for a perforated fungal corneal ulcer. His best spectacle corrected visual acuity (BSCVA) was 6/60 in LE. Slit-lamp examination of LE revealed circumcorneal congestion with full thickness corneal graft with micro and macrobullae, diffuse stromal edema, DM folds and seven well-buried sutures. Intraocular pressure was 20 mmHg in the right eye whereas it could not be assessed in the left eye. The diagnosis of LE failed PK was made and the patient underwent DMEK. At four months postoperative follow up visit, BSCVA improved to 6/9. This is the first reported case of DMEK after a failed PK in a young patient from Nepal which was successfully treated without any complications.
Conclusion: DMEK has a higher potential for better visual rehabilitation compared to DSEK and PK. It has also proved its efficacy in the treatment of endothelial graft failure following PK as it is a less invasive procedure.
Aplikasi Informasi Adat Pernikahan Di Pulau Jawa Berbasis Android
Authors: Riantama Septian 
Published: March 2019

Indonesia adalah salah satu Negara kepulauan terbesar di dunia yang tersebar mulai dari sabang sampai merauke. Kekayaan yang dimiliki oleh masyarakat Indonesia bukan hanya berupa kekayaan sumber alam saja, Salah satu kekayaan kebudayaan tersebut adalah adat pernikahan yang tersebar di pulau jawa. Jawa adalah sebuah pulau di Indonesia dengan penduduk 136 juta, pulau ini merupakan pulau berpenduduk terbanyak di dunia dan merupakan salah satu wilayah berpenduduk terpadat di dunia. Pulau ini dihuni oleh 60% penduduk Indonesia. Pulau ini secara administrative terbagi menjadi empat provinsi, yaitu Jawa Barat, Jawa Tengah, JawaTimur, dan Banten serta dua wilayah khusus, yaitu DKI Jakarta dan DI Yogyakarta. Nilai kebudayaan telah melekat di dalam masyarakat Indonesia, nilai-nilai kebudayaan tersebut sangat beragam antara wilayah satu dengan wilayah yang lain pun akan berbeda. Namun di era sekarang ini nilai kebudayaan di dalam masyarakat telah mulai meluntur bahkan ada sebagian yang mulai menghilang. Salah satu penyebabnya adalah era globalisasi. Sehingga tidak jarang masyarakat atau khususnya generasi muda yang tidak mengetahui tentang adat pernikahan di Indonesia jika ditanya mengenai hal tersebut. Oleh karena itu aplikasi ini sebagai bentuk informasi serta pengetahuan adat-adat pernikahan di pulau jawa. Aplikasi pengenalan “adat pernikahan di pulau jawa” berbasis android ini, diharapkan dapat membantu masyarakat dan juga generasi-generasi muda untuk lebih mengenal akan adat Budaya pernikahan di jawa yang merupakan warisan dari para leluhur kita agar dapat terus dijaga, dirawat dan dilestarikan.