Abstract P6-02-01: Perceived life expectancy, multimorbidity, and breast cancer screening in older women
Authors: Koroukian SM , Warner DF , Schiltz NK , Cooper GS , Owusu C , Stange KC , Berger NA 
Published: February 2018

Abstract
Objective: Screening mammography (SM) benefits are maximal in women who have a several years' life expectancy. Perceived life expectancy (PLE), however, can be compromised by older age, and/or poor health. Prior studies have shown low rates of SM in younger and/or healthier women, while women who are older and/or those presenting with multimorbidity (MM) continue to undergo screening. The resulting under/overuse of SM causes an imbalance in the use of finite resources that should be rectified as we prepare for population aging. In this study, we investigate the use of SM in women 50 years of age or older in the context of age, PLE, MM, and other social determinants of health.
Methods: This is a cross-sectional study using the nationally-representative 2012 U.S. Health and Retirement Study (n= 8934 women). In addition to demographics, we examined a broad range of variables on social determinants of health; as well as conditions constituting MM, including self-reported chronic conditions (e.g., heart disease), functional limitations (e.g., strength, and mobility limitations), and geriatric syndromes (e.g., low cognitive performance). We defined MM0-MM3 as gradients of MM, based on the occurrence/co-occurrence of chronic conditions, functional limitations, and/or geriatric syndromes. PLE was calculated based on respondent's age-specific assessment of the chance they would live another 10-15 years. The outcome variable was self-reported mammography in the past 2 years. We conducted logistic regression analysis to evaluate the independent and interactive association between each of PLE and MM relative to SM, adjusting for potential confounders.
Results: The median age was 65.7 years; 10.5% were Non-Hispanic Black (NHB), 7.8% were Hispanic, and 3.2% were Other Race. The percent of women with SM was 71.5% in the total population. The median assessment of PLE was a 50% chance of living another 10-15 years. 71.9% of women presented with chronic conditions, 36.8% with functional limitations, and 58.2 with geriatric syndromes. Adjusting for confounders, receipt of mammogram was positively associated with greater certainty of PLE (AOR for an increase of 10% –1.03 (1.01, 1.05)). Compared to those with no conditions (MM0), the co-occurrence of chronic conditions, functional limitations, and/or geriatric syndromes was also positively associated with SM (AOR MM1– 1.48 (1.19, 1.84); AOR MM2– 1.35 (1.09, 1.69); and AOR MM3– 1.29 (1.02, 1.62)). In addition, PLE further strengthened the association between MM and SM. Although age was negatively associated with SM, this interacted with PLE such that the likelihood of having a mammogram was unrelated to age among women 100% certain they would live another 10-15 years.
Conclusion: Both multimorbidity (MM) and perceived life expectancy (PLE) are independently and interactively associated with increased screening mammography (SM), suggesting overuse. Indeed, even among women 75 years of age or older, when SM may be least beneficial, receipt of SM in the past two years was 59.6% in the presence of highest MM gradient, and 68.1% when they were at least 75% certain they will live 10-15 years. A more detailed examination of the basis for PLE is warranted to understand the context in which screening recommendation is made.
Citation Format: Koroukian SM, Warner DF, Schiltz NK, Cooper GS, Owusu C, Stange KC, Berger NA. Perceived life expectancy, multimorbidity, and breast cancer screening in older women [abstract]. In: Proceedings of the 2017 San Antonio Breast Cancer Symposium; 2017 Dec 5-9; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2018;78(4 Suppl):Abstract nr P6-02-01.