bluuebunny/crossref_metadata_2025_split huggingface dataset:
PROTECTIVE ACTIVITY OF NOVEL BENZIMIDAZOLE DERIVATIVES AT EXPERIMENTAL INFLUENZA INFECTION
Authors: Zarubaev V. V. , Vasilieva S. V. , Esaulkova Y. L. , Garshinina A. V. , Veprintseva V. M. , Galochkina A. V. , Protsak Y. S. , Teselkin I. V. , Morkovnik A. S. , Divaeva L. N. , Lavrentieva I. N. 
Published: September 2018

Influenza is an acute respiratory viral infection, which represents an important health problem. Every year, influenza causes epidemics and pandemics, leading to increase in morbidity and mortality in all regions of the globe. Due to the segmental organization of the genome and low accuracy of its replication, the influenza virus is capable of escaping the host’s immune response (antigenic drift), as well as the selection of drug-resistant variants. This calls for constant monitoring of the sensitivity of viral isolates to antiviral drugs and the development of new etiotropic antiviral agents that have alternative targets and mechanisms of activity. The purpose of this study was to characterize the new aminobenzimidazole derivatives as protective agents in lethal influenza infection in white mice. The efficacy of the compounds was assessed by their ability to reduce specific mortality of animals in the course of lethal influenza pneumonia caused by the influenza A/Puerto Rico/8/34 (H1N1) irus, increase the life duration of animals, and normalize the morphological structure of lung tissue comparing to the placebo group. For all the compounds studied, a decrease in the specific mortality of animals (from 20 to 60%) has been shown. The reference drug (oseltamivir phosphate) reduced the mortality of mice by 80%. The benzimidazole derivative 2519 demonstrated the highest indices of protective activity, its use reduced the mortality of animals by 60% and increased their mean day of death by 1.6 days in comparison with the control group. Morphological analysis showed that the activity of derivative 2519 was manifested in the normalization of the morphological structure of lung tissue in the course of influenza pneumonia. On day 5 after infection, the cells of the bronchial epithelium looked intact, in contrast to destroyed cells with numerous viral inclusions in control animals. The foci of inflammation themselves occupied a smaller area compared to the control. At the same time, there was no correlation between the previously obtained data on the virus-inhibiting effect of these compounds in vitro and the data obtained in animals. This suggests that despite the presence of direct antiviral activity detected previously in in vitro experiments, the protective properties of the studied aminobenzimidazoles on animals are caused, in addition to the etiotropic effect, by other pathogenetic factors. In conclusion, amino derivatives of benzimidazole should be considered as compounds that are promising for further development and introduction as an anti-influenza agents.
DETERMINATION OF SOME IMMUNOLOGICAL FEATURES OF HHV-6-MEDIATED INFECTIOUS MONONUCLEOSIS IN CHILDREN BY THE METHOD OF DISCRIMINATORY ANALYSIS
Authors: Filatova E. N. , Solntsev L. A. , Presnyakova N. B. , Kulova E. A. , Utkin O. V. 
Published: September 2018

Human herpesvirus type 6 (HHV-6) is a lymphotropic virus that is an etiological agent of infectious mononucleosis (IM) in children. HHV-6- mediated infectious mononucleosis (HHV-6M) does not have clearly defined clinical features. Nowadays immunopathogenetic aspects of this disease have not been fully understood. The purpose of this work was to study the characteristics of the quantitative composition of populations of immunocompetent cells of peripheral blood in children with HHV-6M. The material for the study was samples of peripheral blood from children with “infectious mononucleosis” diagnosis and from virtually healthy children. Depending on the etiologic cause of the disease, children with IM were divided into three groups: HHV-6M, IM of other etiology and mixed infection (combination of HHV-6 and Epstein–Barr virus and/or Cytomegalovirus). Virtually healthy children formed the fourth group. In blood samples, the absolute content of the following populations of immunocompetent cells was determined by the method of flow cytometry: the total population of T-lymphocytes, T- helpers, cytotoxic T-lymphocytes, double positive T-lymphocytes (CD4+CD8+), NK cells and B-lymphocytes. Discriminant analysis was carried out: based on the obtained data on the population composition of blood cells we constructed a model of a child’s attribution to one of the four groups analyzed in pairs. We used the method of machine learning — the algorithm of gradient boosting over decision trees. It was determined whether it is possible to classify patients on the basis of the studied indicators and which combination of indicators is optimal for classification. As a result of the study it was possible to classify the following pairs of groups: healthy children — children with HHV- 6M, healthy children — children with IM of other etiology, children with HHV-6M — children with IM of other etiology. When solving the problem of classifying children from group with mixed infection and from any other group, it was not possible to find a model of satisfactory quality. In comparison with virtually healthy children, children with HHV-6M were characterized by an increased content of the total population of T-lymphocytes and cytotoxic T-cells, as well as by a reduced content of doub le-positive T-lymphocytes. Compared with children with IM of other etiology, children with HHV-6M were characterized by an increased content of cytotoxic T-lymphocytes, T- helpers, B-lymphocytes and a reduced number of double-positive T cells. Our results indicate that HHV-6-mediated infectious mononucleosis causes changes in the quantitative composition of certain populations of immunocompetent cells of peripheral blood, different from those of other etiology, in children.
ASSOCIATION OF THE VARIANTS OF NUCLEOTIDE SEQUENCE OF THE GENE ADIPOQ WITH PLASMATIC LEVEL OF ADIPONECTIN, THE GRADE OF CORONARY ATHEROSCLEROSIS SEVERITY AND RATE OF CARDIOVASCULAR DISEASES
Authors: Smetnev S. A. , Meshkov A. N. , Klimushina M. V. , Gavrilova N. E. , Ershova A. I. , Kiseleva A. V. , Metelskaya V. A. , Drapkina O. M. 
Published: September 2018

Aim. The search for genetic markers of ADIPOQ, associated with the level of adiponectin and development of coronary atherosclerosis.Material and methods. To the study, patients included, who had undergone diagnostic coronary arteriography in 2011-2012 in the NMRCPM with assessment of the severity of coronary atherosclerosis. The level of adiponectin was measured in plasma with the test-system based on the immune enzyme analysis. Genetic variants rs17300539, rs182052 and rs266729 gene ADIPOQ were measured realtime (Applied Biosystems, 7500 Real Time PCR System). Alleles of the studied variants were summarized by a unified score of genetic risk (SGR).Results. To the study, 447 patients included, of those 319 males (70,7%). Median of age was 61 [55-69] y.o. All patients were selected to 2 groups by SGR (≤2 and >2, respectively). Groups differed by the level of adiponectin 7,64 vs 8,29 mcg/mL (р=0,01), total cholesterol 4,60 vs 5,00 mM/L (p=0,03), cholesterol of low density lipoproteides 2,8 vs 3,09 mM/L (p=0,03), and the rate of unstable angina development 2,15% vs 6,8% (р=0,02) and type 2 diabetes 11,8% vs 21,1% (р=0,01), respectively. There was no difference in the groups by Syntax and Gensini score.Conclusion. Genetic score based on the three variants of ADIPOQ does determine the plasmatic level of adiponectin and risk of unstable angina and diabetes, but not the grade of coronary atherosclerosis.
RAISED LEVEL OF LIPOPROTEIDE(A) AS A PREDICTOR OF CARDIOVASCULAR COMPLICATION POST REVASCULARIZATION OF THE LOWER ExTREMETIES ARTERIES
Authors: Tmojan N. A. , Afanasieva О I. , Zotikov A. Е. , Klesareva E. A. , Abdulgamidov M. M. , Ezhov М. V. , Pokrovsky A. V. , Pokrovsky S. N. 
Published: September 2018

Aim. Lipoproteide (a) (Lpa) is a pathogenetic risk factor of cardiovascular atherosclerotic disease. On the role of Lpa in the development of cardiovascular complications (CVC) after lower limbs arteries revascularization, there is lack of data. The aim of the study was assessment of Lpa relation to CVC occurrence after revascularization of lower extremities during 1 year follow-up.Material and methods. In the study, 111 patients were included (97 males, 14 females, mean age 66±9 y.o.), who had undergone revascularization of lower libms arteries due to atherosclerosis. As CVC during 1 year follow-up, the following were taken: recurrent intermittent claudication, lower extremity amputation, ischemic stroke, transient cerebral ischemia, non-fatal myocardial infarction, unstable angina, repeat revascularization and cardiovascular death. In all patients, in the blood serum, there were measured lipids and Lpa.Results. Within 1 year after revascularization there were 45 (41%) CVC. In the group with raised Lpa ≥30 mg/dL there were more CVC than in Lpa <30 mg/dL: relative risk 2,1 (95% CI 1,3-3,5; p=0,004). Hence the increased level of Lpa is an independent predictor of CVC after revascularization of lower extremities arteries.Conclusion. In prospective study, during 1 year after revascularization the level of Lpa ≥30 mg/dL is associated with double increase of the risk of CVC.
A method for assessing the results of survival of an auto-fat graft after lipofilling in patients with breast cancer during surgical rehabilitation
Authors: Zikiryakhodzhayev A. D. , Kalinina–Masri A. A. , Rotobelskaya L. E. , Sukhotko A. S. , Usov F. N. , Ratushnaya V. V. , Evtyagina N. V. 
Published: September 2018

Purpose.Determine the survival of the auto-fat gra a er lipoﬁ lling in the process of reconstruc on in pa ents with breast cancer.Paents and methods. The study included 60 pa ents who underwent lipoﬁ lling both at the ﬁ rst stage of recons tu on and at its ﬁ nal stages. The ar cle describes the procedure for performing the lipoﬁ lling procedure, monitoring and evalua on of the degree of survival of the autologous transplant.Results.As a result of the study, we determined the average survival rate of adiposessue in the recipient zone, which was 76.50% (p <0.00001), which further posi vely aﬀ ects the subsequent stages of reconstruc on and the ﬁ nal result as a whole.Conclusion.Given the good survival of the auto-gra , lipoﬁ lling is part of the surgical rehabilita on of pa ents a er combined / complex / surgical treatment. The procedure is applicable in the ﬁ rst stage of delayed reconstruc on, with the replacement of the ssue expander with a silicone endoprosthesis and as a correc ve method at the ﬁ nal stage of reconstruc on.
Automated skin melanoma diagnostics based on mathematical model of artificial convolutional neural network
Authors: Gavrilov D. A. , Zakirov E. I. , Gameeva E. V. , Semenov V. Yu. , Aleksandrova O. Yu. 
Published: September 2018

In the last 10 years there has been a revolu on in the ﬁ eld of computer image analysis and pa ern recogni on. Modern algorithms of computer vision equaled and even in some problems surpassed human capabili es. This jerk is largely due to the emergence and development of the technology of deep convolu onal neural networks.Recent developments in the ﬁ eld of image processing and machine learning open up the prospect of crea ng systems based on ar ﬁ cial neural convolu onal networks, superior to humans in problems of image classiﬁ ca on, in par cular, in solving problems of analysis of various medical images. Among the most promising applica ons: automated recogni on and classiﬁ ca on of skin diseases, detec on of pathologies on X-ray, CT, MRI, ultrasound imaging. In the proposed project, we will focusour a en on on the diagnosis of human skin diseases.At the moment, melanoma is one of the most dangerous types of malignant tumors of the skin with a lot of deaths due to rapid metastasis, which is diﬃcult to treat. The development of computer vision technology has allowed the development of technical vision systems that allow detec on and classiﬁ ca on of skin diseases with a quality that is comparable and in some cases exceeds the values a ained by man.In this paper, the authors propose an algorithm for the primary diagnosis of skin melanoma based on deep neural networks, achieving an accuracy of 91% for melanoma in dermatoscopic images. At the moment, the algorithm is implemented programma cally and is used in the test version of the online system for detec ng and classifying skin diseases, available at skincheckup.online.Thanks to this development, the prospect of a signiﬁ cantincrease in the propor on of people subjected to preven ve examina on for the presence of skin diseases opens up. Along with this, an addi onal source of informa on for specialized professionals can also play a role in seng the right diagnosis.
Psychoemotional stress in somatically burdened oncological surgery patients as one of the factors of postoperative complications
Authors: Udalov Yu. D. , Gordienko A. V. , Samoilov A. S. , Zabelin M. V. , Bakharev S. A. 
Published: September 2018

Planned surgical interven ons account for more than half of all opera ons in the Russian Federa on, of which more than 20–30% are performed for oncological diseases. Characteris c is an increase in the number of operated pa ents in older age groups with severe concomitant pathology and a high percentage of postopera ve complica ons, including due to psychoemo onal pathology, which can be excluded or adjusted at the preopera ve stage.Purpose.Evalua on of the inﬂ uence of the psychoemo onal state of the oncochirical soma cally burdened patient on the lethality and revealing the possibility of correc on of the psychoemo onal state at the preopera ve stage.Paents and methods. In the period from 2006 to 2016 in the departments of therapy and oncology of the Regional Clinical Hospital of the City Clinical Hospital No. 40 of the Moscow City Health Department, AI.Burnazyan The FMBA of Russia analyzed the treatment of 958 soma cally burdened pa ents with various oncopathology who underwent opera ve interven on in a planned manner. An analysis of the psychoemo onal state of pa ents before and aft er surgery was performed using Hamilton diagnos c scales.Results.After a retrospec ve evalua on, it was determined that prac cally all patients of the oncosurgical proﬁ le undergo various psychoemo onal strains of varying strength and dura on, both before and after surgery. This can disrupt the blood ﬂ ow in the organs andssues, and lead to various complica ons, which manifests itself in the form of hypoxia and ischemia, which, in turn, jus fy the development of postopera ve delirium and myocardial infarc on.Conclusions.Clear distinctions between the anxiety severity in groups on outcomes of hospitaliza on of the oncosurgical patient were determined, and the tendency of the rela onship between the level of the anxiety state and the postopera ve complica ons that had been ridden in the early postopera ve period in soma cally burdened pa ents was determined. Patients of the oncosurgical proﬁ le without fail are shown psychopharmacotherapy in the pre- and postopera ve periods, depending on the revealed pathology.
Leyes de los Reinos de las Indias
Authors: Mahecha Gloria Andrea , Mazuera Paula 
Published: September 2018

En el presente artículo se realiza un análisis de las Leyes de los Reinos de las Indias: compendio de normas dictadas por los colonizadores españoles después de la conquista, a manera de carta de navegación religiosa, jurídica, económica y moral para los pobladores de las tierras descubiertas que garantizara el control sobre el nuevo territorio, las riquezas y la cultura. Sin embargo, a menudo se constituían en fuente de error, pues los contextos en los que debían implantarse resultaban ajenos a los propios, desconociendo la vida de los indígenas, sus tradiciones, relaciones sociales y la apropiación del territorio. Así, mientras los españoles dictaban desde Castilla normas inverosímiles, de imposible aplicación, sus encomendaderos las distorsionaban, acomodaban y ejecutaban de acuerdo a su conveniencia.
En contraste, la ilustración y más adelante el llamado despotismo ilustrado con la visión europea, inhibía la aplicación de las leyes trayendo ideas revolucionarias que cambiaron la visión teocéntrica del mundo, a una con alejamiento del pensamiento religioso. Si bien en las Américas la influencia del nuevo pensamiento no fue tan impactante, la preocupación por las riquezas llevó a la monarquía a abrir el gobierno colonial a los criollos (españoles nacidos en las nuevas tierras), constituyéndose en una clase en ascenso y marcando un camino para la liberación de las colonias, la conquista de los derechos, la resistencia y la liberación.
apuesta por un reconocimiento constitucional amplio del derecho al trabajo y a la seguridad social en Ecuador
Authors: Guamán Adoración , Llorente Raúl 
Published: September 2018

La integración del derecho al trabajo en el constitucionalismo social de posguerra se caracterizó, entre otras cuestiones, por la incorporación de la división del trabajo, diferenciando entre aquél remunerado, integrado en las normas constitucionales y sobre el que se asentó en gran medida el reconocimiento de un amplio conjunto de derechos sociales; y el no remunerado, ausente del reconocimiento constitucional y normativo y condenado a la invisibilización y a ser acumulado sobre el anterior. Esta diferenciación se fundamentó, evidentemente, en la división sexual del trabajo integrada en la conjunción del patriarcado con el sistema capitalista y recogida en las normas del constitucionalismo social de posguerra. Sobre un marco constitucional permeado por esta división sexual del trabajo, el conjunto de normas que han regulado las prestaciones de trabajo asalariado se basó igualmente en esta división. ¿Es posible acometer un reconocimiento constitucional del trabajo no remunerado de cuidados y anudarle derechos? El presente artículo sostiene que sí y mantiene que no solo es posible sino imprescindible y que el reconocimiento debe conllevar el establecimiento de una serie de derechos a las personas que lo realizan. En este sentido, la Constitución de Ecuador demuestra cómo el nuevo constitucionalismo latinoamericano incorporó una concepción amplia del trabajo, reconociendo tanto aquel valorado en términos económicos, remunerado, como aquél no remunerado en la esfera de los cuidados y de la reproducción de la vida.
Sin embargo, y el ejemplo de Ecuador en el ámbito del desarrollo normativo del derecho anterior es clave para apuntalar esta hipótesis, que sea posible no implica en absoluto que sea fácil en el plano de la técnica legislativa y que no genere importantes cuestionamientos desde el punto de vista doctrinal
Faiz Oranları, Döviz Kurları ve Çekirdek Fiyat Endeksleri Arasındaki Dinamik İlişkiler: Türkiye Örneği
Authors: Kofoğlu İsmail Hakkı , Küçükkale Yakup , Yamak Rahmi 
Published: September 2018

Bu
çalışmada çekirdek fiyat endeksleri (A, B, C, D) ve TÜFE ile Faiz, USD ve EURO
arasındaki dinamik ilişkiler Türkiye’nin 2003Q1-2016Q4 dönemi için
araştırılmıştır. Bu bağlamda değişkenler
arasındaki ilişki, birim kök, eş-bütünleşme ve nedensellik testleri ile analiz
edilmiştir. Elde edilen analiz sonuçlarına göre çekirdek fiyat endeksi A ile
Faiz-USD ve Faiz-Euro; Çekirdek Fiyat endeksi C ile Faiz-USD ve Faiz-Euro;
çekirdek fiyat endeksi D ile Faiz-EURO arasında eşbütünleşme ilişkisi
belirlenmiştir. Nedensellik analizine göre USD’den Faize doğru tek yönlü ve
EURO ile Faiz arasında ise çift yönlü bir nedensellik ilişkisi tespit
edilmiştir. Ayrıca, Euro’dan çekirdek
fiyat endeksi A, C ve D’ye tek yönlü bir nedensellik ilişkisi olduğu
görülmüştür. Sonuç olarak EURO’dan çekirdek fiyat endeksi A, C ve D’ ye
geçişkenlik olduğu sonucuna ulaşılmıştır.
Parametrizaciones de curvas y superficies: Construcción de sólidos con GeoGebra 3D
Authors: Mora Picado Luis Fernando 
Published: September 2018

En este artículo se presenta la elaboración de sólidos con sus respectivas aristas, generados por la intersección de superficies, utilizando para ello el software libre GeoGebra 3D, elaborado por Hohenwarter (2015), lo que se hace una inducción rápida de los comandos que se utilizarán, así como una breve reseña de como parametrizar segmentos de curvas, en el programa.
Paso a paso se construyen ejemplos, sobre la construcción de secciones de curvas y las áreas determinadas por dichas curvas elaboradas previamente, dando así forma a los sólidos que pretenden construir.
Además, se brinda al lector algunos ejercicios para que ponga en práctica los conocimientos adquiridos, así como algunas soluciones de los ejercicios planteados.
El algoritmo PSO aplicado al problema de particionamiento de datos cuantitativos
Authors: Chavarría Molina Jeffry , Fallas Monge Juan José 
Published: September 2018

Este artículo muestra la aplicación del algoritmo de Enjambre de Partículas (Particle Swarm Optimization: PSO) al problema de particionamiento de datos cuantitativos. Se enfatiza particularmente en la calibración de los parámetros de este algoritmo y el rendimiento que éste muestra en función de los valores asignados a los parámetros. Finalmente, se muestra la aplicación del algoritmo a diez tablas de datos cuantitativos. En este experimento se obtuvieron buenos resultados en términos de la convergencia del algoritmo y los tiempos de ejecución.
Different Places, Different Ideas: Reimagining Practice in American Psychiatric Nursing After World War II
Authors: Smith Kylie M. 
Published: September 2018

AbstractIn 1952, Hildegard Peplau published her textbook Interpersonal Relations in Nursing: A Conceptual Frame of Reference for Psychodynamic Nursing. This was the same year the American Psychiatric Association (APA) published the first edition of the Diagnostic and Statistical Manual of Mental Disorders (1st ed.; DSM-I; APA). These events occurred in the context of a rapidly changing policy and practice environment in the United States after World War II, where the passing of the National Mental Health Act in 1946 released vast amounts of funding for the establishment of the National Institute of Mental Health and the development of advanced educational programs for the mental health professions including nursing. This article explores the work of two nurse leaders, Hildegard Peplau and Dorothy Mereness, as they developed their respective graduate psychiatric nursing programs and sought to create new knowledge for psychiatric nursing that would facilitate the development of advanced nursing practice. Both nurses had strong ideas about what they felt this practice should look like and developed distinct and particular approaches to their respective programs. This reflected a common belief that it was only through nurse-led education that psychiatric nursing could shape its own practice and control its own future. At the same time, there are similarities in the thinking of Peplau and Mereness that demonstrate the link between the specific social context of mental health immediately after World War II and the development of modern psychiatric nursing. Psychiatric nurses were able to gain significant control of their own education and practice after the war, but this was not without a struggle and some limitations, which continue to impact on the profession today.