bluuebunny/crossref_metadata_2025_split huggingface dataset:
Adapalene Gel 0.1% Versus Placebo as Prophylaxis for Anti-Epidermal Growth Factor Receptor-Induced Acne-Like Rash: A Randomized Left-Right Comparative Evaluation (APPEARANCE)
Authors: Chayahara Naoko , Mukohara Toru , Tachihara Motoko , Fujishima Yoshimi , Fukunaga Atsushi , Washio Ken , Yamamoto Masatsugu , Nakata Kyosuke , Kobayashi Kazuyuki , Takenaka Kei , Toyoda Masanori , Kiyota Naomi , Tobimatsu Kazutoshi , Doi Hisayo , Mizuta Naomi , Marugami Naho , Kawaguchi Atsushi , Nishigori Chikako , Nishimura Yoshihiro , Minami Hironobu 
Published: March 2019

Abstract

Lessons Learned
The results of the APPEARANCE trial indicate that adapalene does not prevent acne-like rash over placebo when added to topical moisturizer and oral minocycline but instead may have a detrimental effect. Therefore, adapalene is not recommended as prophylaxis against acne-like rash induced by anti-epidermal growth factor receptor therapies. Given that acne-like rash was completely controlled with placebo in approximately half of patients, predictive measures to identify patients needing intensive prophylaxis are required.

Background
Anti-epidermal growth factor receptor (EGFR) therapies are frequently associated with acne-like rash. To evaluate the prophylactic efficacy of adapalene, a topical retinoid used as first-line therapy for acne vulgaris, we conducted a randomized, placebo-controlled, evaluator-blinded, left-right comparative trial.

Methods
Patients with non-small cell lung, colorectal, or head and neck cancer scheduled to receive anti-EGFR therapies were randomly assigned to once-daily adapalene application on one side of the face, with placebo on the other side. All patients had topical moisturizer coapplied to both sides of the face, and received oral minocycline. The primary endpoint was the difference in total facial lesion count of acne-like rash at 4 weeks. Secondary endpoints included complete control rate (CCR) of acne-like rash (≤5 facial lesions) and global skin assessment (Investigator's Global Assessment [IGA] scale, grade 0–4) at 4 weeks. Two blinded dermatologists independently evaluated the endpoints from photographs.

Results
A total of 36 patients were enrolled, of whom 26 were evaluable. Adapalene treatment was associated with a greater lesion count than placebo at 4 weeks, although the difference was not statistically significant (mean, 12.6 vs. 9.8, p = .12). All four patients with a difference &gt;10 in lesion count between face sides had a greater count on the adapalene-treated side. No significant differences were observed in CCR of acne-like rash (54% vs. 50%) or IGA scale (mean grade, 1.9 vs. 1.7) between the adapalene and placebo sides.

Conclusion
Adapalene is not recommended as prophylaxis against acne-like rash induced by anti-EGFR therapies.
MODERNIZAÇÃO E LAICIDADE: O MODELO FORMATIVO DA IMPRENSA ESPÍRITA BRASILEIRA DO SÉCULO XIX
Authors: Rocha Alessandro Santos da 
Published: March 2019

Este artigo analisa três periódicos da imprensa espírita brasileira da segunda metade do século XIX, quando o Espiritismo passou a ser disseminado no Brasil por meio de textos favoráveis a instauração do Estado laico. Foram analisados os seguintes periódicos: O Écho d’Além Túmulo: monitor do Espiritismo no Brasil (1869-1870), a Revista Espírita: publicação mensal de estudos psicológicos (1875), e a Revista da Sociedade Acadêmica Deus, Cristo e Caridade (1881-1882). Em comum, os periódicos expunham os princípios da Doutrina Espírita codificados por Alan Kardec. Apesar da perspectiva religiosa, os textos analisados estamparam o debate sobre a transformação social mediante o discurso cientificista visto como modernizador. Neste sentido, a imprensa espírita pode ser ponderada como os demais jornais, panfletos e revistas que assumiram lugar significativo na formação dos indivíduos do Brasil Império. As suas particularidades buscavam aproximar a ideologia cientificista e o universo religioso com o propósito de comprovar a existência de comunicação entre o universo físico e o mundo espiritual. Todavia, a permanência desse tipo de pensar só seria possível numa sociedade em que o Estado não perpetuasse uma única perspectiva religiosa, ou seja, a do Catolicismo. Destarte, fazia se necessário laicizar as relações políticas do Império para que a Doutrina Espírita pudesse prosperar. O estudo realizado sobre a imprensa espírita demonstra que ela não se restringiu ao âmbito religioso, do contrário, estimulou a formação intelectual dos sujeitos. O conceito de Educação empregado neste trabalho acata que a imprensa pode ser entendida como agente formativo, pautado no aspecto da educação informal. Para este estudo foi utilizada a abordagem histórica e documental, a qual considerou a contextualização do Brasil Imperial, bem como a apreciação crítica das publicações lançadas pela impressa espírita da época.
Gebelerin stresle başa çıkma tarzları ile yaşam kalitesi arasındaki ilişki
Authors: Dağlar Gülseren , Nur Naim , BİLGİÇ Dilek , Aydın Özkan Semiha 
Published: March 2019

Amaç: Bu çalışmada gebelerin stresle başa çıkma tarzları ile yaşam kalitesi arasındaki ilişkiyi belirlemek amaçlanmıştır.Gereç ve Yöntem: Kesitsel tipte planlanan araştırmanın evrenini Sivas İl Merkezinde yaşayan gebeler oluşturmuştur. Araştırma, 1 Aralık 2015 -1 Mart 2016 tarihleri arasında Sivas Merkezde bulunan 6 Aile Sağlığı Merkezi’nde yapılmış, örneklemi 242 gebe oluşturmuştur. Veriler Kişisel Bilgi Formu, Stresle Başa Çıkma Tarzları Ölçeği ve Dünya Sağlık Örgütü Yaşam Kalitesi Ölçeği ile toplanmıştır. Bulgular: Gebelerin kendine güvenli ve iyimser yaklaşım puanı ile fiziksel, psikolojik, sosyal ve çevresel alan yaşam kalitesi puanı arasında pozitif yönde ve zayıf büyüklükte istatistiksel anlamlı ilişki bulunmuştur. Çaresiz yaklaşım ve boyun eğici yaklaşım puanı ile psikolojik, sosyal ve çevresel alan yaşam kalitesi puanı arasında negatif yönde zayıf büyüklükte istatistiksel anlamlı ilişki saptanmıştır. Ayrıca sosyal destek arama davranışı ile sosyal ve çevresel alan yaşam kalitesi puanı arasında pozitif yönde ve zayıf büyüklükte istatistiksel anlamlı ilişki belirlenmiştir.Sonuç: Stresle başa çıkmada kendine güvenli ve iyimser yaklaşım kullanan gebelerin yaşam kalitesinin tüm alanları ve sosyal destek arama davranışında sosyal ve çevresel alan yaşam kalitesi olumlu etkilenirken, çaresiz ve boyun eğici yaklaşımda psikolojik, sosyal ve çevresel alan yaşam kalitesi olumsuz etkilenmektedir. Gebelerin stres yönetimi becerilerinin geliştirilmesi önerilmektedir.
Posterior fossa cerrahisinde anestezi yönetimi
Authors: KARACAER Feride 
Published: March 2019

Amaç: Posterior fossa cerrahisinde anestezi yönetimi, anatomik özellikler, hasta profilinin değişkenliği ve operasyon pozisyonu nedeniyle özelliklidir. İntraoperatif hemodinamik değişiklikler, beyin sapı hasarı ve venöz hava embolisi gibi komplikasyonlar oluşabilmektedir. Bu çalışmada, hastanemizde posterior fossada tümör nedeniyle opere olan hastalardaki anestezi deneyimlerimizin paylaşılması ve sonuçlarımızın literatür eşliğinde tartışılması amaçlanmıştır.Gereç ve Yöntem: Hastanemizde 2015-2017 yılları arasında posterior fossada tümör cerrahisi uygulanan 1 ile 77 yaş arasındaki 30 hastanın kayıtları retrospektif olarak değerlendirildi. Bulgular: Hasta yaşlarının 1 ile 74 yıl arasında olup, hastaların %76,7’sinin erkek olduğu saptandı. Ortalama operasyon süresi 242,7 dakika idi. İntraoperatif dönemde 6 (%20) hastada hipotansiyon, 4 (%13,3) hastada bradikardi, 1 (%3,3) hastada asistoli, 2 (%6,6) hastada venöz hava embolisi geliştiği tespit edildi. 25 (%83,3) hastanın operasyon sonunda ekstübe edildiği, 5 (%16,7) hastanın ise entübe şekilde yoğun bakım ünitesine çıkarıldığı saptandı. Yoğun bakım ünitesinde ortalama kalış süresi 5,6±4,6 gün, hastanede kalış süresi 14,7±15,7 gün idi. Postoperatif dönemde 5 (%16,7) hastanın yeniden opere edildiği, 1 (%3,3) hastanın exitus olduğu, 29 (%96,7) hastanın ise hastaneden taburcu edildiği saptandı. Sonuç: Posterior fossa cerrahisinde anestezi yönetimi, dinamik ve zorlu bir süreç olabilmektedir. Uygun hasta seçimi ve preoperatif hazırlık, intraoperatif monitörizasyon ve anestezik ajanların seçimi ile komplikasyon oranı en aza indirilebilmektedir.
Formulation Development and Evaluation of Rosuvastatin Sustained Release Tablets
Authors: Gunda Raghavendra Kumar , Manchineni Prasada Rao 
Published: March 2019

Purpose: The main objective of present research investigation is to formulate the sustained release formulation of Rosuvastatin. Rosuvastatin, an antihyperlipidemic agent, belongs BCS class-II agent.Methods: The SR tablets of Rosuvastatin were prepared employing different concentrations of HPMCK4M and SCMC in different combinations by Direct Compression using 32 factorial design. The concentration of Polymers , HPMCK4M and SCMC required to achieve the desired drug release was selected as independent variables, X1 and X2 respectively whereas, time required for 10% of drug dissolution (t10%), 50% (t50%), 75% (t75%) and 90% (t90%) were selected as dependent variables.Results and Discussion: Totally nine formulations were designed and are evaluated for hardness, friability, thickness, % drug content, In-vitro drug release. From the Results it was concluded that all the formulation were found to be with in the Pharmacopoeial limits and the In-vitro dissolution profiles of all formulations were fitted in to different Kinetic models, the statistical parameters like intercept, slope & regression coefficient were calculated. Polynomial equations were developed for dependent variables. Validity of developed polynomial equations were verified by designing 2 check point formulations (C1, C2). According to SUPAC guidelines the formulation (F4) containing 30 mg of HPMCK4M and 40 mg of SCMC, is the most similar formulation (similarity factor f2= 89.561, dissimilarity factor f1= 1.543 & No significant difference, t= 0.0056) to marketed product (CRESTOR).Conclusion: The selected formulation (F4) follows Zero order, Higuchi’s kinetics, and the mechanism of drug release was found to be Non-Fickian Diffusion (n= 0.963).
PERANCANGAN KARTU SKOR BERIMBANG (BALANCED SCORE CARD) PADA PERUSAHAAN SURAT KABAR
Authors: Ilyas Giri Pratama , Harymawan Iman 
Published: March 2019

Tujuan dari penelitian ini yaitu untuk menunjukkan rancangan Balanced Scorecard pada perusahaan surat kabar harian terbesar di wilayah timur Indonesia dan memaparkan hubungan sebab akibat sasaran strategi pada Strategy Map untuk meraih visi dan misi perusahaan. Penelitian ini menggunakan pendekatan kualitatif studi kasus. Data diperoleh dengan wawancara semi terstruktur dari beberapa informan yang terkait dengan penyusunan sasaran strategi pada perusahaan surat kabar harian. Penyusunan sasaran strategi dan Key Performance Indicators (KPI) diidentifikasi melalui penjabaran visi dan misi yang dimiliki PT.XYZ. Setelah itu, sasaran strategi dan KPI yang teridentifikasi didefinisikan ke dalam Balanced Scorecard. Penulis menggunakan perusahaan surat kabar harian XYZ karena PT.XYZ tidak memiliki kerangka yang mengaitkan antara sasaran strategi dan KPI yang sesuai dengan visi dan misi PT.XYZ. Hasil dari penelitian ini menunjukkan bahwa perancangan balanced scorecard pada PT.XYZ menghasilkan 14 sasaran strategi dan 26 KPI. Perspektif pertumbuhan dan pembelajaran memiliki 3 sasaran strategi dan 7 KPI. Perspektif proses bisnis internal memiliki 6 sasaran strategi dan 11 KPI. Perspektif pelanggan memiliki 2 sasaran strategi dan 4 KPI. Perspektif keuangan memiliki 3 sasaran strategi dan 4 KPI. Penetapan sasaran strategi dan KPI pada perspektif dalam Balanced Scorecard telah sesuai dan sejalan dengan visi dan misi perusahaan. Alur hubungan sebab akibat sasaran strategi hingga ke visi dan misi perusahaan tertuang pada Strategy Map.
ANALISIS PERBEDAAN PERSEPSI AKADEMISI AKUNTANSI TERHADAP PENERAPAN MATA KULIAH AKUNTANSI SYARIAH ( Studi Kasus pada Universitas Muhammadiyah Surabaya )
Authors: Maharani Rieska , Nuraini Fitri , A Andrianto 
Published: March 2019

This study aims to determine differences in perceptions of academics of accounting on the application of sharia accounting courses at the University of Muhammadiyah Surabaya. The object of this study is the perception of accounting academics on the application of sharia accounting subjects with the sampling technique is purposive sampling. The method used deskrip qualitative research by distributing questionnaires and interviews. Results are used to deploy as many as 7 lectures and 21 accounting students who took thesis.Based on the results of questionnaires and interviews can be concluded that there are no differences in the perception of accounting academics of sharia accounting courses at the University of Muhammadiyah Surabaya. And both parties agree will demonstrate the application of sharia accounting subjects, with the course is expected to prospective accountant can apply. Keywords: Perception, Islamic Accounting
PEGARUH GOOD CORPORATE GOVERNANCE TERHADAP EFISIENSI BANK SYARIAH TAHUN 2012-2016 DENGAN KINERJA SOSIAL SEBAGAI VARIABEL INTERVENING
Authors: Ghofur Abdul , Sukmaningrum Puji Sucia 
Published: March 2019

This study aims to determine the effect of Good Corporate Governance and social performance on efficiency in Bank Syariah Period 2012-2016. The sample in this study used a purposive sampling method of Islamic Commercial Banks (BUS) in Indonesia, from 13 BUS took 6 BUS that met the sample criteria to be tested. Furthermore, this research uses path analysis, while the research approach used is quantitative approach using analysis technique PLS (Partial Least Square). In this research, there are three latent variables namely Good Corporate Governance as an exogenous or independent variable, social performance as endogen intervention variable, and efficiency as an endogen variable. The indicators used to reflect the Good Corporate Governance Variables are the Board of Commissioners (DK), the Composition of Independent Commissioners (KDKI), the Sharia Supervisory Board (DPS), the Frequency of Sharia Supervisory Board Meetings (FRDPS), and the Frequency of Audit Committee Meetings (FRKA). The indicators used to reflect social performance are financing Mudharabah-Musyarakah, Zakat, and Qard.. Furthermore, the efficiency indicator is reflected by the ratio of BOPO (Operational Cost to Operating Income).The results of this study indicate that GCG has a significant positive effect on efficiency, GCG has a significant positive effect on social performance, social performance has a significant negative effect on efficiency, GCG has a significant negative effect on efficiency through social performance. Keywords: Good Corporate Governance, Social Performance, Efficiency, Islamic Banks
Human Resource Development in the Era of Technology; Technology’s Implementation for Innovative Human Resource Development
Authors: Zarqan Ince Ahmad 
Published: March 2019

Rapid changes in technology have affected businesses in an uncountable way, strength of a company can be measured based on the level of technology that implemented for the sake of efficiency, it posseses that the “technovation” (technology and innovation) is one of the key for improvement of human resource. Surely, it is a single important factor for a human resource management as an organization should be able to identify an improvement of its human resources. Thus, the primary purpose of the present paper is to analyze the current effects of technology on HR processes, consider the existing literature on the topic, and discuss the advantages and efficiency. In this scenario, there is a need to clearly identify a technology for an efficient management of human resources which is able to improve skills of the employees. A number of key areas of the impacts of technology on human resource development that are discussed in order to gain an innovative human resource development.Keyword : Human Resource, Development, Technology, Improvement
Lean Hospital Management, Studi Empirik pada Layanan Gawat Darurat
Authors: Usman Indrianawati , Ardiyana Mira 
Published: March 2019

This research focuses on implementing lean management in hospital service, in order to elimination of waste to make a better performance. It’s a qualitative single case study research. This study will identified waste and show how to reduce waste using lean management by empirically research in intensive care unit of Islamic hospital in Surabaya. Quantitative tools and measurement also used in this research using value stream analysis tools, and process activity mapping in order to identify the value added and non value added activities. The results of the analysis indicate that there are seven kind of waste. Next the value stream analysis and process activity mapping show that the most frequent waste that cause ineffective performance of hospital service are waiting time, service defect and inappropriate process.
Design and Implementation of Thematic Assignment in Integrating the Local Context - Concepts - Global Context
Authors: Mandang Theresje , Medellu Christophil S. 
Published: March 2019

<p>Utilization of the surrounding environment as a learning resource is considered superior in improving comprehensively the knowledge, psychomotor and student affection. Learning about the environment (nature, socio-culture) allows new information to enrich the experience gained by students from outside the classroom. The surrounding environment-based learning should be enriched with information from relevant external sources, among others through mass media or reference/learning resources. Learning comes from the surrounding environment is very relevant and useful for schools (junior and senior high school) in the small island that experienced problems of lack of teaching materials, and the limitations of teachers. An interesting learning strategy in the development of learning comes from the surrounding environment is to compile and associate facts and phenomena (nature and social culture) that is around with external information that is passed through mass media or printed sources, photographs etc. This article discusses the design and experimental design of teaching in the form of thematic tasks that emphasize the learning process through comparison activities and local context associations with global context based on the concept of science and mathematics. The results of the experiments show that the group of students have the motivation and active activities of comparison and association of local context with global, although the mastery of science and mathematics concepts are not so good. Students generally perceive good and excellent design and testing of learning activities.</p>
Użyteczność metod radioizotopowych w leczeniu przerzutów nowotworowych do układu kostnego – przegląd metod
Authors: Zając Roksana , Radzińska Paulina , Pietrzak Agata Karolina , Wiecheć Katarzyna , Żurawski Jakub , Cholewiński Witold 
Published: March 2019

StreszczenieLeczenie dolegliwości bólowych będących konsekwencją przerzutów nowotworowych w układzie kostnym stanowi ważny problem kliniczny z uwagi na istotne obniżenie jakości życia chorego onkologicznego. Towarzyszące zaawansowanej chorobie nowotworowej zmiany przerzutowe oprócz bólu, są także przyczyną złamań patologicznych oraz upośledzenia funkcji ruchowych pacjenta, a nieleczone mogą być przyczyną krytycznych dla życia chorego powikłań. Zastosowanie leczenia radioizotopowego jako jednej z form terapii paliatywnej, jest ważnym i efektywnym sposobem zapobiegania komplikacjom zdrowotnym związanym z rozwojem przerzutów do układu szkieletowego.Abstract Palliative therapy in patients’ suffering from metastatic bone lesions is an important clinical problem due to a significant reduction in the quality of life of an oncological patient. The metastatic bone lesions regardless pain are also the cause of pathological fractures and impairments of the patient's motor functions and untreated can affect mortality more often than primary neoplastic disease. The palliative therapy using radioisotopes seems to be an important and effective method which might prevent the critical health complications caused by the skeletal tumors.
Adequacy of the ASTM C1240 Specifications for Nanosilica Pozzolans
Authors: Hassan Maan S. 
Published: March 2019

Background:
Nano-silica is a new pozzolan that is boosting the field of nanomaterials and can be used effectively in the concrete industry. ASTM C1240 is used to qualify silica fume pozzolans for use in concrete and for marketing purposes.

Objective:
The present study aims to assess the adequacy of ASTM C1240 in qualifying nanosilica for use in concrete and to introduce a modified procedure to measure the pozzolanic activity of nanosilica used with cementitious composites.

Methods:
The effects of various particle sizes and dosages on the compressive strength of blends in standard mortar were investigated. The correlation between the chemical reactivity and the compressive strength were also investigated using TGA and XRD analyses. The criterion conceived was validated at two ages: 7 days and 28 days.

Results and Conclusion:
The strength activity index results revealed that the following standard procedure ASTM C1240 is not applicable for nanosilica due to the high surface area and great pozzolanic reactivity of SiO2 nanoparticles, so a lower cement replacement percentage should be used. This study suggests that it be no more than 7%. The pozzolanicity testing results confirm that a nanosilica replacement level of more than 7% could not be effective in transforming further Portlandite into a C-S-H or other major cementing compound, leading to a “false negative” for nanosilica pozzolans.
Preparation and Characterization of Rutile Titania Nanofluids Stabilized in Different Surfactants Base Fluids
Authors: El-Salamony Radwa A. , Abd-Elaziz Mohamed Z. , Morsi Rania E. , Al-Sabagh Ahmed M. , Hassan Saad S.M. 
Published: March 2019

Background:
Improvement of conventional heat transfer fluids for achieving higher
energy efficiencies in thermal equipment is a key parameter to conserve energy in industries. The
heat transfer fluids such as water, oil and ethylene glycol greatly suffer low heat transfer performance
in industrial processes. There is a need to develop new types of heat transfer fluids that are
more effective in terms of heat transfer performance. Nanofluids enhance thermal conductivity
and improve the thermal performance of heat transfer systems.

Methods:
New titania nanofluid samples consisting of 0.0625 to 1% TiO2 nanoparticles were
prepared and characterized. The method of preparation was based on prior precipitation of TiO2
from an ammoniacal solution of pH 9 and calcination at 900°C. Solubilization, homogenization
and stabilization of the of the nanoparticles were performed by sonication in the presence of sodium
dodecyl sulfate (SDS) anionic surfactant and cetyltrimethylammonium bromide (CTAB)
cationic surfactant.

Results:
This treatment was also utilized to increase the stability and improve the thermal properties
of the fluid.

Conclusion:
Several characterization techniques including measurements of hydrodynamic size
distribution, zeta potential, transmission electron microscopy (TEM), viscosity, density, specific
heat, thermal conductivity, and sedimentation photo capturing were used to measure and confirm
the stability and sedimentation rate of the prepared nanofluids.