bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dissecting genomic hotspots underlying seed protein, oil, and sucrose content in an interspecific mapping population of soybean using high‐density linkage mapping
Authors: Patil Gunvant , Vuong Tri D. , Kale Sandip , Valliyodan Babu , Deshmukh Rupesh , Zhu Chengsong , Wu Xiaolei , Bai Yonghe , Yungbluth Dennis , Lu Fang , Kumpatla Siva , Shannon J. Grover , Varshney Rajeev K. , Nguyen Henry T. 
Published: April 2018

SummaryThe cultivated [Glycine max (L) Merr.] and wild [Glycine soja Siebold & Zucc.] soybean species comprise wide variation in seed composition traits. Compared to wild soybean, cultivated soybean contains low protein, high oil, and high sucrose. In this study, an interspecific population was derived from a cross between G. max (Williams 82) and G. soja (PI 483460B). This recombinant inbred line (RIL) population of 188 lines was sequenced at 0.3× depth. Based on 91 342 single nucleotide polymorphisms (SNPs), recombination events in RILs were defined, and a high‐resolution bin map was developed (4070 bins). In addition to bin mapping, quantitative trait loci (QTL) analysis for protein, oil, and sucrose was performed using 3343 polymorphic SNPs (3K‐SNP), derived from Illumina Infinium BeadChip sequencing platform. The QTL regions from both platforms were compared, and a significant concordance was observed between bin and 3K‐SNP markers. Importantly, the bin map derived from next‐generation sequencing technology enhanced mapping resolution (from 1325 to 50 Kb). A total of five, nine, and four QTLs were identified for protein, oil, and sucrose content, respectively, and some of the QTLs coincided with soybean domestication‐related genomic loci. The major QTL for protein and oil were mapped on Chr. 20 (qPro_20) and suggested negative correlation between oil and protein. In terms of sucrose content, a novel and major QTL were identified on Chr. 8 (qSuc_08) and harbours putative genes involved in sugar transport. In addition, genome‐wide association using 91 342 SNPs confirmed the genomic loci derived from QTL mapping. A QTL‐based haplotype using whole‐genome resequencing of 106 diverse soybean lines identified unique allelic variation in wild soybean that could be utilized to widen the genetic base in cultivated soybean.
Helminth parasitizing <em>Iberolacerta cyreni</em> (Müller et Hellmich, 1937) from Gredos Mountains, Iberian Peninsula
Authors: Roca Vicente 
Published: April 2018

A survey of the helminth communities of a population of Iberolacerta cyreni (Müller et Hellmich, 1937), a small lizard endemic to Sistema Central (Iberian Peninsula), was conducted to determine the prevalence, abundance and species diversity of parasites of these reptiles. Four species of helminths were found, one trematode, Plagiorchis molini Lent et Freitas, 1940, one cestode, Nematotaenia tarentolae López-Neyra, 1944, and two nematodes, Skrjabinelazia sp. and Spauligodon carbonelli Roca & García-Adell, 1988. Helminth infracommunities of I. cireny showed very low values of abundance and species richness and diversity, being similar to other European lizards. The parasites found seem to have no influence on the conservation status of the host species in its natural habitat
.
Genome Sequence of the Proteorhodopsin-Containing Bacterium Flavobacterium sp. Strain TH167, Isolated from Cyanobacterial Aggregates in a Eutrophic Lake
Authors: Cai Haiyuan , Chen Feng 
Published: April 2018

ABSTRACT

Flavobacterium
is the most abundant group of bacteria within the cyanobacterial aggregates in Lake Taihu, China. Here, we present the genome sequence and annotation of
Flavobacterium
sp. strain TH167. Genome analysis revealed the presence of a proteorhodopsin-encoding sequence, together with its retinal-producing pathway, indicating a putative photoheterotrophic lifestyle that generates energy from light.
Draft Genome Sequence of the Fish Pathogen Flavobacterium columnare Genomovar III Strain PH-97028 (=CIP 109753)
Authors: Criscuolo Alexis , Chesneau Olivier , Clermont Dominique , Bizet Chantal 
Published: April 2018

ABSTRACT

Flavobacterium columnare
strain PH-97028 (=CIP 109753) is a genomovar III reference strain that was isolated from a diseased Ayu fish in Japan. We report here the analysis of the first available genomovar III sequence of this species to aid in identification, epidemiological tracking, and virulence studies.
Genomic Sequence of Saccharomyces cerevisiae BAW-6, a Yeast Strain Optimal for Brewing Barley Shochu
Authors: Kajiwara Yasuhiro , Mori Kazuki , Tashiro Kosuke , Higuchi Yujiro , Takegawa Kaoru , Takashita Hideharu 
Published: April 2018

ABSTRACT

Here, we report the draft genome sequence of
Saccharomyces cerevisiae
strain BAW-6, which is used for the production of barley shochu, a traditional Japanese spirit. This genomic information can be used to elucidate the genetic basis underlying the high alcohol production capacity and citric acid tolerance of shochu yeast.
Complete Genome Sequence of the Methanococcus maripaludis Type Strain JJ (DSM 2067), a Model for Selenoprotein Synthesis in Archaea
Authors: Poehlein Anja , Heym Daniel , Quitzke Vivien , Fersch Julia , Daniel Rolf , Rother Michael 
Published: April 2018

ABSTRACT

Methanococcus maripaludis
type strain JJ (DSM 2067) is an important organism because it serves as a model for primary energy metabolism and hydrogenotrophic methanogenesis and is amenable to genetic manipulation. The complete genome (1.7 Mb) harbors 1,815 predicted protein-encoding genes, including 9 encoding selenoproteins.
Hospital-level care coordination strategies associated with better patient experience
Authors: Figueroa Jose F , Feyman Yevgeniy , Zhou Xiner , Joynt Maddox Karen 
Published: April 2018

BackgroundPatient experience is a key measure of hospital quality and is increasingly contained in value-based payment programmes. Understanding whether strategies aimed at improving care transitions are associated with better patient experience could help clinical leaders and policymakers seeking to improve care across multiple dimensions.ObjectiveTo determine the association of specific hospital care coordination and transition strategies with patient experience.DesignWe surveyed leadership at 1600 acute care hospitals and categorised respondents into three groups based on the strategies used: low-strategy (bottom quartile of number of strategies), mid-strategy (quartiles 2 and 3) and high-strategy (highest quartile). We used linear regression models to examine the association between use of these strategies and performance on measures of patient experience from the Hospital Consumer Assessment of Healthcare Providers and Systems survey.ResultsWe achieved a 62% response rate. High-strategy hospitals reported using 7.7 strategies on average usually or always on their patient populations, while mid-strategy and low-strategy hospitals reported using 5.0 and 2.3 strategies, respectively. Compared with low-strategy hospitals, high-strategy hospitals had a higher overall rating (+2.23 percentage points (pp), P<0.001), higher recommendation score (+2.5 pp, P<0.001), and higher satisfaction with discharge process (+1.35 pp, P=0.01) and medication communication (+1.44 pp, P=0.002). Mid-strategy hospitals had higher scores than low-strategy hospitals except for discharge satisfaction. Patient-facing strategies, like sharing discharge summaries with patients prior to discharge, using discharge coordinators and calling patients 48 hours after discharge, were each individually associated with a higher overall hospital rating, and higher satisfaction with discharge process and medication communication.ConclusionsHospitals with greater reported use of care coordination and transition strategies have better patient experience than hospitals with fewer reported strategies. Strategies that most directly involve patients have the strongest association with better experience.
Clinical assessment of balance using BBS and SARAbal in cerebellar ataxia: Synthesis of findings of a psychometric property analysis
Authors: Winser Stanley John , Smith Catherine M , Hale Leigh A , Claydon Leica S , Whitney Susan L 
Published: April 2018

Background: In the previous psychometric analysis paper in our series for identifying the core set of balance measures for the assessment of balance, we recommended the Berg Balance Scale (BBS) and balance sub-components of the Scale for the assessment and rating of ataxia (SARAbal) as psychometrically sound measures of balance for people with cerebellar ataxia (CA) secondary to multiple sclerosis. Objective: The present study further examined the suitability of BBS and SARAbal for the assessment of balance in CA with regard to psychometric property strength, appropriateness, interpretability, precision, acceptability and feasibility. Methods: Criteria to fulfill each factor was defined according to the framework of Fitzpatrick et al. (1998). Based on the findings of our previous psychometric analysis, each criterion was further analyzed. Results: The psychometric analysis reported good reliability and validity estimates for the BBS and SARAbal recommending them as psychometrically sound measures; they fulfilled both criteria for appropriateness and interpretability, the measures showed evidence for precision and acceptability, and they were found to be feasible in terms of the time and cost involved for the balance assessment. Conclusion: We have provided evidence for the use of the BBS and SARAbal for the assessment of balance among people with CA.
Mu-oscillation changes related to the development of anticipatory postural control in children and adolescents
Authors: Barlaam Fanny , Fortin Carole , Vaugoyeau Marianne , Schmitz Christina , Assaiante Christine 
Published: April 2018

Anticipatory postural adjustments (APAs) cancel the destabilizing effects of movement on posture. Across development, the maturation of APAs is characterized by an accurate adjustment of the timing parameters of electromyographic (EMG) response. The study aimed at investigating the maturation of cortical oscillations involved in the improvement of APAs efficiency. Thirty-six healthy participants (8–16 yr) performed the bimanual load-lifting task in which subjects are instructed to lift a load, placed on the left forearm, with the right hand. EMG data were acquired over the biceps brachii on the postural arm to the determine EMG response onset. Electroencephalographic signals were analyzed in the time-frequency domain by convolution with complex Gaussian Morlet wavelets. Electrophysiological signature of APAs in children and adolescents consisted of a mu-rhythm desynchronization over the sensorimotor cortex contralateral to the postural arm. Across development, the mu-rhythm desynchronization was characterized by a progressive shift forward of the onset of the desynchronization, lower amplitude, and velocity. These changes occurred along with an alteration of the timing of the EMG response, as shown by an earlier onset of the flexor inhibition with increasing age. The maturational changes in the Mu-oscillations might sustain the development of APAs. A possible role of the Mu-oscillation in the generation of postural command is discussed. NEW & NOTEWORTHY Across development, our study showed a progressive shift forward of the parameters of the mu-rhythm desynchronization. These changes occurred along with an alteration of the timing parameters of the electromyographic response, as shown by an earlier onset of the flexor inhibition with increasing age. The progressive development of APAs during childhood and adolescence might therefore be sustained by maturational electrophysiological changes that include mu-rhythm oscillation modifications in the postural sensorimotor cortex.
A System-Level Approach to Improve the Uptake of Antiestrogen Preventive Therapy among Women with Atypical Hyperplasia and Lobular Cancer In Situ
Authors: Brewster Abenaa M. , Thomas Priya , Brown Powel , Coyne Robin , Yan Yuanqing , Checka Cristina , Middleton Lavinia , Do Kim-anh , Bevers Therese 
Published: April 2018

Abstract
Background: The low uptake of antiestrogen preventive therapy among women at high risk of developing breast cancer remains a challenge. We implemented a performance improvement program to increase the uptake of preventive therapy among women with atypical hyperplasia (AH) and lobular cancer in situ (LCIS).
Methods: A performance improvement program was implemented at the MD Anderson Cancer Center (Houston, TX), November 2015 to February 2017, for patients with a new (&lt;6 months) or existing (≥6 months) diagnosis of AH/LCIS. The program consisted of an audit of eligible women who were recommended and prescribed preventive therapy and the provision of clinical performance feedback to providers. The baseline uptake of preventive therapy was estimated from patients enrolled in a high-risk breast cohort.
Results: Baseline uptake of preventive therapy was 44%. The program registered 408 patients with a new (n = 87) or existing diagnosis (n = 321) of AH/LCIS; mean age was 57 and 71% were non-Hispanic white. Ninety-eight percent of patients received a recommendation for preventive therapy. The overall prescribing of preventive therapy to patients with a new or existing diagnosis was 82% (monthly range, 40%–100%; Ptrend = 0.76) and 48% (monthly range, 27%–57%; Ptrend &lt; 0.01), respectively. Adherence among patients with a new or existing diagnosis was 76% and 48% (P &lt; 0.01) at 6 months, respectively.
Conclusion: A system-level approach improved the uptake of preventive therapy. Identifying women at the time of diagnosis of AH/LCIS and offering a strong recommendation are key components for improving acceptance and adherence with preventive therapy. Cancer Prev Res; 11(5); 295–302. ©2018 AACR.
Effect of dental pain and caries on the quality of life of Brazilian preschool children
Authors: Freire Maria do Carmo Matias , Corrêa-Faria Patrícia , Costa Luciane Rezende 
Published: April 2018

OBJECTIVE: To investigate the impact of dental pain on daily performances among five-year-old Brazilian children. METHODS: The study used data of 7,280 five-year-old children participating in the 2010 Brazilian Oral Health Survey (SBBrasil 2010 Project). Children were clinically examined and their parents or carers were interviewed at their homes. The outcome was the prevalence of the oral impacts on daily performance, and the explanatory variable was dental pain in the last six months. Other independent variables were children’s gender and skin color/race, family income, household overcrowding, and caries experience (dmft). Rao-Scott test and Poisson regression for complex samples were carried out. RESULTS: The prevalence of impacts on daily performances was 26.1% (95%CI 22.3–30.2). Significant associations were found between the outcome and pain, caries experience, and sociodemographic variables. After adjusting for the independent variables, only pain and caries remained significant. Impacts on daily performances were more frequent among children with pain (PR = 1.14, 95%CI 1.06–1.23) compared to those without pain. Children with low dmft (PR = 1.90, 95%CI 1.39–2.60) and those with high dmft (PR = 3.53, 95%CI 2.78–4.49) had a higher prevalence of impact than those with no caries experience. CONCLUSIONS: Dental pain and caries had strong negative impacts on the five-year-old children’s daily performances regardless of their demographic and socioeconomic characteristics.
Differentiating Ventricular From Supraventricular Arrhythmias Using the Postpacing Interval After Failed Antitachycardia Pacing
Authors: Bennett Matthew T. , Leader Nathan , Sapp John , Parkash Ratika , Gardner Martin , Healey Jeffrey S. , Thibault Bernard , Sterns Larry , Essebag Vidal , Birnie David , Sivakumaran Soori , Nery Pablo , Andrade Jason G. , Krahn Andrew D. , Tang Anthony 
Published: April 2018

Background:
Implantable cardioverter defibrillator arrhythmia discrimination algorithms often are unable to discriminate ventricular from supraventricular arrhythmias. We sought to evaluate whether the response to antitachycardia pacing (ATP) in patients with an implantable cardioverter defibrillator could further discriminate ventricular from supraventricular arrhythmias in patients receiving ATP.

Methods and Results:

All episodes of ventricular or supraventricular tachycardia where ATP was delivered in patients enrolled in RAFT (Cardiac-Resynchronization Therapy for Mild-to-Moderate Heart Failure Trial) were included. RAFT randomized 1798 patients with New York Heart Association class II/III heart failure, left ventricular ejection fraction ≤30%, and QRS duration of ≥120 ms to a implantable cardioverter defibrillator±cardiac resynchronization therapy. The tachycardia cycle lengths (TCLs) before and after the delivery of ATP and the postpacing intervals were assessed. Overall, 10 916 ATP attempts were reviewed for 8150 tachycardia episodes in 924 patients. After excluding tachycardias where ATP terminated the episode or where the specific mechanism of the tachycardia was uncertain, we analyzed 3676 ATP attempts delivered for 2046 tachycardia episodes in 541 patients. A shorter difference between postpacing interval and TCL (PPI−TCL) was more likely to be associated with ventricular tachycardia than with supraventricular tachyarrhythmia (138.1±104.2 versus 277.4±126.9 ms;
p
<0.001). Analysis of the receiver operator curve for the PPI−TCL revealed an area under the curve of 0.803 (
p
<0.001; 95% confidence interval, 0.784–0.822). The majority of tachycardias with a PPI−TCL >360 ms were supraventricular with a PPI−TCL value of ≤360 ms having a sensitivity of 97.4% and specificity of 28.3% for ventricular tachycardia.

Conclusions:
The ATP response, specifically the PPI−TCL, can further discriminate ventricular from supraventricular arrhythmias in patients with implantable cardioverter defibrillators when the currently available discriminators fail.

Clinical Trial Registration:

URL:
https://www.clinicaltrials.gov
. Unique identifier: NCT00251251.
Geographic Variations in In‐Hospital Mortality and Use of Percutaneous Coronary Intervention Following Acute Myocardial Infarction in China: A Nationwide Cross‐Sectional Analysis
Authors: Chen Hui , Shi Lizheng , Xue Ming , Wang Ni , Dong Xiao , Cai Yue , Chen Jieqing , Zhu Weiguo , Xu Hua , Meng Qun 
Published: April 2018

Background

Prevalence of acute myocardial infarction (
AMI
) is increasing in China, and AMI has become a major cause of mortality; however, information is very limited about the nationwide geographic and hospital variation in in‐hospital mortality (
IHM
) and the use of percutaneous coronary intervention (
PCI
) after
AMI
.

Methods and Results

From the Nationwide Hospital Discharge Database of China, we identified 242 866 adult admissions with
AMI
in 2015 from 1055 tertiary hospitals. We used multivariable logistic regressions to analyze the associations between geographic or hospital characteristics with
IHM
or
PCI
use. The national
IHM
rate was 4.71% (95% confidence interval, 4.62–4.79%). There was a greater risk of mortality in the Northeast (odds ratio [
OR
]: 1.86), West (
OR
: 1.73), South (
OR
: 1.32), and North (
OR
: 1.14) regions than in the East region of China. Non–teaching hospitals (
OR
: 1.18) and tertiary level B hospitals (
OR
: 1.06) were associated with higher
IHM
rates. The national
PCI
use rate was 45.3% (95% confidence interval, 45.1–45.5%). Compared with the East region of China,
PCI
use was lower in the Northeast (
OR
: 0.50), West (
OR
: 0.64), North (
OR
: 0.84), and South (
OR
: 0.88) regions. Non–teaching hospitals (
OR
: 0.83) and tertiary level B hospitals (
OR
: 0.55) were also associated with lower usage rates. There was a significant negative correlation between
IHM
and
PCI
use (
r
=−0.955), and
IHM
rates for patients with and without
PCI
both differed by geographic regions.

Conclusions

There were significant differences in
IHM
and
PCI
use among China's tertiary hospitals, linked to both geographic and hospital characteristics. More targeted intervention at national and regional levels is needed to improve access to effective health technologies and, eventually, outcomes following
AMI
.
IL‐23R Deficiency Does Not Impact Atherosclerotic Plaque Development in Mice
Authors: Engelbertsen Daniel , Depuydt Marie A. C. , Verwilligen Robin A. F. , Rattik Sara , Levinsohn Erik , Edsfeldt Andreas , Kuperwaser Felicia , Jarolim Petr , Lichtman Andrew H. 
Published: April 2018

Background

Interleukin‐23 (
IL
‐23) has been implicated in inflammatory and autoimmune diseases by skewing
CD
4
+
T helper cells towards a pathogenic Th17 phenotype. In this study we investigated the presence of
IL
‐23 receptor (
IL
‐23R)‐expressing cells in the atherosclerotic aorta and evaluated the effect of
IL
‐23R deficiency on atherosclerosis development in mice.

Methods and Results

We used heterozygous
Ldlr

−/−

Il23r

e

GFP

/

WT

knock‐in mice to identify
IL
‐23R‐expressing cells by flow cytometry and homozygous
Ldlr

−/−

Il23r

e

GFP

/

eGFP

(
Ldlr

−/−

Il23r

−/−

) mice to investigate the effect of lack of
IL
‐23R in atherosclerosis. We demonstrate the presence of relatively rare
IL
‐23R‐expressing cells in lymphoid tissue and aorta (≈0.1–1%
IL
23R
+
cells of all
CD
45
+
leukocytes). After 10 weeks on a high‐fat diet, production of
IL
‐17, but not interferon‐γ, by
CD
4
+
T cells and other lymphocytes was reduced in
Ldlr

−/−

Il23r

−/−

compared with
Ldlr

−/−

controls. However,
Ldlr

−/−

and
Ldlr

−/−

Il23r

−/−

mice had equivalent amounts of aortic sinus and descending aorta lesions. Adoptive transfer of
IL
‐23R‐deficient
CD
4
+
T cells to lymphopenic
Ldlr

−/−

Rag1

−/−

resulted in dramatically reduced
IL
‐17‐producing T cells but did not reduce atherosclerosis, compared with transfer of
IL
‐23R‐sufficient
CD
4
+
T cells.

Conclusions

These data demonstrate that loss of
IL
‐23R does not affect development of experimental atherosclerosis in
LDL
r‐deficient mice, despite a role for
IL
‐23 in differentiation of
IL
‐17‐producing T cells.
Generating New Musical Works in the Style of Milton Babbitt
Authors: Bemman Brian , Meredith David 
Published: April 2018

Abstract
Milton Babbitt is noted for composing twelve-tone and serial music that is both complex and highly constrained. He has written extensively on a variety of topics in music and his writings have had a profound and lasting impact on musical composition. In this article, we first review in detail his compositional process and the techniques he developed, focusing in particular on the all-partition array, time-point system, and equal-note-value strings used in his later works. Next, we describe our proposed procedure for automating his compositional process using these techniques. We conclude by using our procedure to automatically generate an entirely new musical work that we argue is in the style of Babbitt.
Accidental Environmentalists
Authors: Kent Eliza F. , Orlowska Izabela 
Published: April 2018

Abstract
In the highlands of Ethiopia, the only remaining stands of native forest are around churches of the Ethiopian Orthodox Tewahido Church. Though hailed as community-conserved areas by environmentalists, we argue that the conservation of such forest is not intentional, but rather an indirect result of the religious norms, beliefs and practices surrounding the sites. In actuality, the religiosity surrounding church forests maintains the purity of the most holy space in the center of the shrine, the tabot, a replica of the Ark of the Covenant, which ensures that the church is a legitimate and effective portal to the divine. An underlying cultural logic of purity and pollution structures the spatial organization of the site outward into a series of concentric circles of diminishing purity and shapes the social order into an elegant hierarchy. This article seeks to understand the norms, beliefs and practices of this sacred geography in its social and religious context, arguing that ignorance of or inattention to these can undermine the conservation goals that have brought these forests, along with so many other sacred natural sites, to the attention of environmentalists around the world.