bluuebunny/crossref_metadata_2025_split huggingface dataset:
A biologia educacional e a higiene escolar na década de 1940: a (in)visibilidade das diferenças na educação brasileira
Authors: Morando André , Souza Nadia Geisa Silveira de 
Published: May 2019

Nesse artigo analisamos o livro intitulado Biologia Educacional: noções fundamentais. Essa obra foi utilizada como livro didático nas Escolas Normais, do Brasil, a partir do final da década de 30 do século passado. Pela perspectiva foucaultiana, examinamos e problematizamos a rede de enunciados, do higienismo, da medicina social e da educação escolar primária, presente no funcionamento da Escola Normal através da disciplina biologia educacional. Os enunciados veiculados no livro funcionam como estratégias de governamento, de corpos e de condutas vinculadas ao saneamento dos problemas econômicos do país, tendo a futura professora primária e os alunos da zona rural como alvos e ferramentas da transformação econômica e social
Entrevista com o professor Valdemir Miotello sobre Bakhtin e as perspectivas para as pesquisas na área da educação
Authors: Miotello Valdemir , Araújo Michell Pedruzzi Mendes , Dias Israel Rocha 
Published: May 2019

Nesta entrevista, realizada com o professor Valdemir Miotello da Universidade Federal de São Carlos, abordamos a relevância de Mikhail Bakhtin para o campo da educação, principalmente sobre as possibilidades que esse teórico abre para o desenvolvimento de pesquisas nessa área. Tendo em vista a necessidade do outro para o nosso processo de nascimento cultural, para inserir-se em um grupo social e para a aprendizagem e o desenvolvimento do ser humano, buscamos um ‘outro’, no contexto dessa entrevista o professor Dr. Valdemir Miotello, para nos tornar mais ‘fortes’, nesse ínterim, advogamos que o ‘eu’ se torna mais forte no ‘nós’. É nesse contexto de relações alteritárias e dialógicas que apresentamos esta entrevista. Pretendemos que esse texto dialógico e as tecituras desenvolvidas nele possam ser molas propulsoras para estudantes, professores, pesquisadores, dentre outros que almejem compreender melhor o pensamento do teórico Bakhtin e as potencialidades da sua perspectiva para alicerçar teoricamente os estudos na/da área da educação.
As narrativas digitais interativas e transmídia e a sua aplicação na aprendizagem: o storytelling encontrou o CONSTRUIT e partiram em busca do SLIDE
Authors: Sousa Vanda Maria 
Published: May 2019

RESUMO: Nos dias de hoje, o termo storytelling explode numa miríade de aceções. Para muitos, reporta ao contador de tempos ancestrais; para outros, pode ser a nova descoberta na área do marketing e da publicidade (MILLER, 2014) para outros, ainda, convoca à reflexão o conceito de narrativas digitais (JENKINS, 2001). Aqui consideramos o storytelling enquanto ferramenta de aprendizagem. Como esperamos demonstrar, ignorar o potencial das narrativas digitais como ferramenta de aprendizagem é, a limite, ignorar o potencial da linguagem como performativa da identidade. Para isso, convocámos a experiência da Modelagem Empírica (Empirical Modelling) que tem vindo a ser desenvolvida na Warwick University, Conventry com expressão na conferência CONSTRUIT 2017 e pretendemos demonstrar que a narrativa digital interativa transmídia pode, com sucesso, ser utilizada pela Modelagem Empírica (M.E.) na aprendizagem e literacia tecnológica dos seniores. Para tal, tomámos como referência, o projeto europeu SLIDE. A nossa premissa é que o ato comunicacional e as narrativas digitais sustentam, com sucesso, estes modelos de aprendizagem independendo da idade do aprendente.
PALAVRAS-CHAVE: narrativas digitais; storytelling; modelo empírico; literacia.

ABSTRACT: Nowadays, the term storytelling explodes in a myriad of meanings. For many, it reports to ancestral times; for others, maybe it is a new discovery in the field of marketing and advertising (MILLER, 2014). For others, yet, it implies the reflection under the concept of digital narratives (JENKINS, 2006). Here we consider storytelling as a learning tool. As we hope to demonstrate, ignoring the potential of digital narratives as a learning tool is, in the end, ignoring the potential of language as performative of identity. Being so, we have summoned the experience of Empirical Modeling (E.M.) developed at Warwick University, Conventry, namely, the outputs presented at the CONSTRUIT 2017 conference and we intend to demonstrate that interactive digital narrative transmigration can successfully be used by the Empirical Modeling (M.E.) in the learning and technological literacy of seniors. To this end, we have taken as a reference the European SLIDE project. Our premise is that the communicational act and the digital narratives are successful models of learning regardless of the age of the learner.
KEYWORDS: digital narratives; storytelling; empirical modeling; literacy.
Hamstring Injuries
Authors: Heer Steven T. , Callander John W. , Kraeutler Matthew J. , Mei-Dan Omer , Mulcahey Mary K. 
Published: May 2019

➤ The most predictive factor for hamstring injury is a previous hamstring injury.➤ Magnetic resonance imaging is the most useful study for determining the extent of the hamstring injury and whether surgical intervention is warranted.➤ Conservative treatment is indicated for acute hamstring strains, partial tears, and single-tendon avulsions.➤ Surgical repair of complete proximal hamstring ruptures, both acute and chronic, results in improved outcomes compared with nonoperative management.➤ Repair of acute proximal hamstring tendon tears results in better functional outcomes than repair of chronic tears.➤ Stretching and strengthening the hamstring tendons with eccentric exercise is useful for physical therapy after injury and may reduce the risk of reinjury.
IMAGE ENHANCEMENT CITRA ZOOM DENGAN MENGGUNAKAN METODE BILINEAR INTERPOLATION DARI KAMERA WEBCAM
Authors: Nugroho Hendro , Hakimah Maftahatul , Azinar Azmuri Wahyu 
Published: May 2019

<p align="justify"><em>Kamera Webcam yang terdapat komputer memiliki </em><em>desain yang sangat simple menggunakan lensa standar. Penggunaan kamera Webcam untuk pengambilan citra yang akan di zoom akan menghasilkan efek aliasing atau efek blur. Untuk memperbaiki kualitas citra (Image Enhancement) menggunakan metode Bilinera Interpolation yang diakibatkan efek zoom pada citra, pada penelitian ini menggunakan beberapa tahapan yaitu: cropping, metode Bilinear Interpolation, dan output hasil</em><em>.</em><em> Untuk mengetahui hasil output Image Enhancement, maka dilakukan evaluasi yang menggunakan metode ekstraksi tekstur dengan menggunakan fitur Entropi untuk mengetahui tingkat sebaran piksel setelah di zoom atau sebelum di zoom. Hasil yang didapat untuk tahapan evaluasi pada Image Enhancement memiliki nilai yang sama, menunjukkan hasil citra yang di zoom dan sebelum di zoom memiliki kualitas sama atau tidak ada perubahan.</em></p><p align="justify"><em> </em></p><p><strong><em>Kata kunci:</em></strong><strong><em> Image Enhancement, Biliner Interpolation, Zoom, Ekstrasi Tekstur Fitur Entropi.</em></strong></p>
Genome-wide investigation of heat shock transcription factor family in wheat (Triticum aestivum L.)
Authors: Ye Jiali , Yang Xuetong , Li Sha , Li Wei , Liu Qi , Zhang Lingli , Song Xiyue 
Published: May 2019

Abstract
Background: Heat shock transcription factors (HSFs) play crucial roles in resisting heat stress and regulating plant development. Investigating the HSF family is essential for understanding the fertility conversion mechanism in thermo-sensitive male sterile wheat. Previous studies have investigated the HSF family in wheat but it is necessary to conduct more in-depth and systematic analyses based on the newly published reference genome.
Results: In the present study, 61 wheat Hsf (TaHsf) genes were identified using two main strategies and renamed based on their physical locations on chromosomes. According to the gene structure and phylogenetic analyses, the 61 TaHsf genes were classified into three categories and eleven subclasses. The genes were unequally distributed on 21 chromosomes, including two pairs of tandem duplication genes and 52 TaHsf segmental duplication genes. According to the cis-elements identified, most of the TaHsfs can be activated by Ca++ and MYB, and they respond to drought, light, copper, and other stresses as well as heat shock. RNA-seq analysis indicated that the A2 class TaHsf genes exhibited persistently upregulated expression levels in the leaves/shoots, roots (except in the vegetative growth and reproductive growth stages), spikes, and grains in wheat under normal conditions. The A and B class TaHsf genes were positively regulated during the resistance to heat, whereas the C class genes were involved in drought regulation in wheat. Only the A and B class TaHsf genes were upregulated under fertile conditions in thermo-sensitive male sterile wheat.
Conclusion: In this study, 61 wheat Hsf genes were identified based on the complete wheat reference genome. This comprehensive analysis provides novel insights into the TaHsf genes, including their diverse functions and involvement in metabolic pathways.
Extensive immune reconstitution inflammatory syndrome in Fingolimod-associated PML: a case report with 7 Tesla MRI data
Authors: Sinnecker Tim , Hadisurya Jeffrie , Schneider-Hohendorf Tilman , Schwab Nicholas , Wrede Karsten , Gembruch Oliver , Gold Ralf , Hellwig Kerstin , Pilgram-Pastor Sara , Adams Ortwin , Albrecht Philipp , Hartung Hans-Peter , Aktas Orhan , Kraemer Markus 
Published: May 2019

Abstract
Background

Progressive multifocal leukoencephalopathy (PML) is a rare complication of patients treated with fingolimod.

Case presentation

Routine MRI eventually led to diagnosis of asymptomatic early PML that remained stable after discontinuation of fingolimod. As blood lymphocyte counts normalized, signs of immune reconstitution inflammatory syndrome (IRIS) and renewed MS activity developed. Both, advanced laboratory and ultrahigh field MRI findings elucidated differences between PML and MS.

Conclusions

In our case, early discontinuation of fingolimod yielded a good outcome, lymphocyte counts reflected immune system activity, and paraclinical findings helped to differentiate between PML-IRIS and MS.
Acute and episodic vestibular syndromes caused by ischemic stroke: predilection sites on diffusion-weighted images
Authors: Tong Dao-Ming , Chen Xiao-Dong , Zhou Ye-Ting , Yang Tong-Hui 
Published: May 2019

Abstract
Background Although acute vestibular syndrome (AVS) and episodic vestibular syndrome (EVS) are an increasingly recognized cause of acute ischemic stroke, the predilection sites of AVS/EVS caused by acute ischemic stroke still is less known.

Methods From Mar 2014 to Mar 2016 period, we used a new approach of 11thedition of the International Classification of Diseases (ICD-11) to retrospectively enrolled patients with identified AVS/EVS events caused by acute ischemic stroke in the stroke center of tertiary teaching hospital. The patients who had positive diffusion-weighted images (DWI) lesion and MRA were analyzed. Multivariable logistic regression was used to identify the risk of stroke causing AVS/EVS.
Results Among 181 AVS/EVS patients with ischemic stroke, 68 (37.6%) patients with acute ischemic stroke were proved by DWI. Of them, the most frequent type was EVS (60.3%); the predilection sites of stroke was in the insular (51.7%, 15/29) in the anterior circulation artery (ACA), followed by the posterior of thalamus (28.6%, 8/28) in the posterior circulation artery (PCA). The lesion on DWI showed a median diameter of 4.0mm (range,0.6-89.4). The risk of AVS/EVS in acute ischemic stroke was found in association with large vessel stenosis/ occlusion (odds ratio[OR],, 0.12; 95% confidence interval [CI], 0.040-0.357), focal neurological symptom /sign (OR, 0.27; 95% CI, 0.104-0.751), and higher initial ABCD2 score (OR, 0.37; 95% CI, 0.239-0.573).
Conclusions The predilection site of the AVS/EVS caused by acute ischemic stroke is in the insular. The risk of AVS/EVS was associated with a large vessel stenosis, focal neurological symptoms, and higher initial ABCD2 score.
The relationship between Hyperuricemia and Contrast-induced acute kidney injury undergoing primary percutaneous coronary intervention: the protocol of secondary analysis for ATTEMPT RESCIND-1 study
Authors: Guo Wei , Song Feier , Chen Shiqun , Zhang Li , Sun Guoli , Liu Jin , Chen Jiyan , Liu Yong , Tan Ning 
Published: May 2019

Abstract
Background

Contrast-induced acute kidney injury (CI-AKI) contributes toward unfavorable clinical outcomes after primary percutaneous coronary intervention (pPCI). We assessed whether hyperuricemia is an independent predictor of CI-AKI and outcomes in patients undergoing pPCI.

Methods/design

Our study was a secondary analysis for the database from ATTEMPT study, enrolling 560 ST-segment elevation myocardial infarction (STEMI) patients undergoing pPCI. Eligible patients received peri-procedural either via aggressive (left ventricular end-diastolic pressure guided) or routine (<=500ml) intravenous hydration with the isotonic solution (0.9% NaCl) with randomization. The primary endpoint was CI-AKI, defined as >25% or 0.5 mg/dL increase in serum creatinine from baseline during the first 48-72 hours post-procedurally. Patients were divided into 2 groups according to the admission serum uric acid (SUA) level. Hyperuricemia was defined as a SUA level >7 mg/dL (417 mmol/L) in males and >6 mg/dL (357 mmol/L) in females. Multivariate analyses for CI-AKI and long-term mortality were performed using the logistic regression and Cox regression analyses, respectively.

Discussion

This study will determine the predictive value of hyperuricemia for the development of CI-AKI and outcomes in patients with STEMI undergoing pPCI. We predict that hyperuricemia will be associated with a risk of CI-AKI in patients with pPCI. Furthermore, after adjusting for other variables, long-term mortality after pPCI was higher in those with hyperuricemia than in those with normouricemia. Results of this study may provide scientific evidence for the effect of hyperuricemia on CI-AKI and long-term outcomes, thereby offering the potential possibility of lowering SUA on the development of CI-AKI and outcomes.
Systematic review of basket trials, umbrella trials, and platform trials: A landscape analysis of master protocols
Authors: Mills Edward J , Park Jay JH , Siden Ellie , Zoratti Michael J , Dron Louis , Harari Ofir , Singer Joel , Lester Richard T , Thorlund Kristian 
Published: May 2019

Abstract
Background

Master protocols, classified as basket trials, umbrella trials, and platform trials, are a novel approach that offers enhanced efficiency and a more ethical approach to trial evaluation. Despite the many advantages of these designs, they are infrequently used.

Methods

We conducted a landscape analysis of published master protocols using a systematic literature search to determine what trials have been conducted, with an overall goal of improving literacy in this emerging concept. English-language studies identified from MEDLINE, EMBASE, and CENTRAL databases and hand-searches of published reviews and registries from inception to October 1st, 2018

Results

We identified 59 master protocols (35 basket-, 13 umbrella-, 11 platform trials). The number of master protocols has increased rapidly over the last five years. Most have been conducted in the US (n=32/59) and investigated experimental drugs (n=58/59), in the field of oncology (n=53/59). The majority of basket trials were exploratory (i.e. phase I/II; n=33/35) and not randomized (n=30/35), with half only investigating a single intervention. The median sample size of basket trials was 208 participants (Interquartile range, Q3-Q1 [IQR]: 589-92), with a median study duration of 60.9 (IQR: 71.9-39.9) months. Similar to basket trials, most of umbrella trials were exploratory (n=11/13), but use of randomization was more common (n=8/13). The median sample size of umbrella trials was 342 participants (IQR: 400-250), with a median study duration of 62.9 (IQR: 82.8-46.9) months. The median number of interventions investigated in umbrella trials was 5 (IQR: 5-4). In platform trials, randomization (n=10/11) and phase III investigation (n=5/10; one did not report information on phase), with four of them using seamless II/III design, were more common. The median sample size was 783.5 (IQR: 1857.5-319.5), with median study duration of 63.3 (IQR: 115.0-41.9) months.

Conclusions

We anticipate that the number of master protocols will continue to increase at a rapid pace over the upcoming decades. More efforts to improve awareness and training are needed to apply these innovative trial design methods to fields outside of oncology.
The OMACS-PIL study - a randomised controlled study within the OMACS observational study
Authors: Culliford Lucy , Brierley Rachel , Clout Maddie , Evans Rebecca , Maishman Rachel , Phillips Dawn , Tabusa Hana , Reeves Barney , Rogers Chris A 
Published: May 2019

Abstract
Background

There has been little research to investigate whether the appearance of paper Patient Information Leaflets (PILs) used to describe research studies to potential participants influences their decision to take part. Embedding a Study Within a Study (SWAS) is an efficient way of answering this type of methodological question. We included a randomised SWAS within a large cohort study, Outcome monitoring After Cardiac Surgery (OMACS), to address this question.

Methods

Potential participants for the OMACS study were randomised to receive one of three PILs, identical in content but with varying formatting and use of colour: PIL A (enhanced format), PIL B (hybrid format) and PIL C (standard format). Consent to OMACS was the primary outcome. Consent rates using the three different PIL formats were collected and compared.

Results

For the SWAS, 1517 PILs were sent to potential participants and 640 (42%) consented to take part in OMACS. PIL B had the highest recruitment rate, with 45% of patients consenting to participation; 40% and 41% of patients consented to participation with PIL A and C respectively. Compared to PIL C, the consent rate was 4% higher with PIL B (45% versus 41%, 95% Confidence Interval (CI) -2% to +10%, p=0.16) and 1% lower with PIL A (40% versus 41%, 95% CI -7% to +5%, p=0.72).

Conclusions

PIL B, a hybrid format, led to the highest consent rate, and this format is being used for the remainder of the host study and will be used to inform the design of PILs for other research studies.
Fire needle plus cupping for acute herpes zoster: Study protocol for a randomised controlled trial
Authors: Zhang Ying , Liang Zuohui , Li Shihua , Yang Ling , Lin Guohua , Yang Juanjuan , Xu Qiannan , Zhang Qing , Zhao Jian , Liu Xiuhong , Guo Taipin 
Published: May 2019

Abstract
Abstract
Background
Herpes zoster (HZ) is a common skin disease caused by invasion of the varicella-zoster virus into the ganglia and skin. Severe pain caused by HZ seriously affects the normal life of patients; thus, pain often becomes the patient’s first complaint. Fire needle plus cupping may be effective for acute herpes zoster (AHZ), but the evidence is insufficient.
Methods
This is a three-arm randomized controlled trial with an observation time of 1 week. A total of 96 patients with AHZ pain are divided into three groups by stratified randomization, with 32 in each group: (a) fire needle + cupping (FC); (b) famciclovir + gabapentin (FG), famciclovir hydrochloride, 3 × 0.25 g/d orally (p.o.), with an individualized dose of gabapentin 900-3600 mg/d p.o.; and (c) fire needle + cupping + famciclovir (FCF). The above intervention lasts for 1 week, and all patients receive analgesia (nonopioid analgesics [analgin or paracetamol] and opioid analgesics [tramadol or morphine]). Groups a and c undergo 1 to 7 sessions of fire needles and cupping treatments per patient, with gabapentin and analgesic medication administered depending on the patient’s needs. The primary outcome measure is the assessment of changes in pain intensity before and after treatment (visual analogue scale ranging from 0-100 mm). Secondary outcome measures are changes in substance P and beta-endorphin concentrations in peripheral plasma before and after treatment. Quantitative scoring methods are used to evaluate the symptoms and physical signs before and after treatment, including pain classification, local itching, burning sensation, fever, local lymphadenopathy, skin lesion area, blisters, herpes clusters, vesicular traits, ulcers, and pimples. In addition, analgesic needs and side effects are evaluated.
Discussion: The results of this study will be obtained by randomised controlled trial(RCT), and the outcomes will be analyzed and evaluated to prove FC may be effective for AHZ.
Trial registration :The registration number is ChiCTR1800015372. Registered on 28 March 2018.
Reduction of scum production in a modified UASB reactor treating domestic sewage
Authors: Pereira J. O. , Rocha J. M. , Pinto W. B. C. C. , Moreira C. T. S. 
Published: May 2019

Abstract
The scum accumulation inside gas–solid–liquid separators (GSL) is one of the main limitations of upflow anaerobic sequencing batch (UASB) reactors during treatment of domestic sewage. Although this type of reactor can be equipped with devices that periodically remove scum, this solution has been proved to be very expensive in addition to being inefficient when discharging procedures are not correctly performed. The main goal of this study was to investigate the performance of a modified UASB reactor concept with a GSL separator which promotes continuous scum discharge to the settling compartment. Furthermore, this proposal was compared with a conventional UASB reactor which was used as control. Both reactors in demo-scale were fed with domestic wastewater and scum production was measured. The results demonstrated volumetric reduction of 50%, and 75% reduction in the mass of total solids in the modified reactor. Additionally, the amount of biogas recovered from the modified reactor was higher than the amount that the control reactor recovered. Therefore, the proposed modification has been proved to be effective, bringing new possibilities to the GSL project.