bluuebunny/crossref_metadata_2025_split huggingface dataset:
Transient in-stent stenosis: a common finding after flow diverter implantation
Authors: Mühl-Benninghaus Ruben , Haußmann Alena , Simgen Andreas , Tomori Toshiki , Reith Wolfgang , Yilmaz Umut 
Published: July 2018

Background and purposeIn recent years, implantation of flow diverters has emerged as an option for the endovascular treatment of intracranial aneurysms. One complication of treatment with flow diverters is the occurrence of in-stent stenosis, which has been reported to be partially reversible. The purpose of our study was to assess the incidence and dynamics of in-stent stenosis on angiographic short term and long term follow-up after treatment with flow diverters.MethodsA retrospective review of our prospectively maintained database identified all patients with intracranial internal carotid artery (ICA) aneurysms treated by flow diverters at our institution between 2014 and 2017. Clinical charts, procedural data, and angiographic results were reviewed.Results18 patients were included. The mean short term follow-up was 92±19 days and mean long term follow-up was 449±120 days after treatment. No neurologic complications were observed. There was no procedure related mortality. Long term angiographic results showed complete occlusion in 83.3%, neck remnants in 11.1%, and incomplete occlusion in 5.5% of cases. In-stent stenosis was observed in all cases. Mean stenosis improved significantly from 30% on short term follow-up to 12% on long-term follow-up (P<0.0001).ConclusionIn-stent stenosis is a common finding on short term follow-up after the treatment with flow diverters but improves over time.
Long term follow-up of endovascular management of spinal cord arteriovenous malformations with emphasis on particle embolization
Authors: Collin Adrien , Labeyrie Marc-Antoine , Lenck Stephanie , Zetchi Akli , Aymard Armand , Saint-Maurice Jean-Pierre , Civelli Vittorio , Houdart Emmanuel 
Published: July 2018

ObjectiveTo determine long term safety and efficacy of endovascular treatment of spinal cord arteriovenous malformations (AVMs), with calibrated particle embolization as a firstline approach.MethodsWe reviewed clinical and imaging data of consecutive patients who underwent endovascular treatment for both nidal and fistulous type spinal cord AVMs in our center, from 1990 to 2015. Outcome at the last follow-up was assessed by an independent observer.ResultsEmbolization of spinal cord AVMs was performed in 61 patients, including 46 (75%) with particles (exclusively in 29 patients), 30 (49%) with cyanoacrylate, and 6 (10%) with combined surgical treatments. Particle embolizations were iterative in 33 patients (median number of sessions 5 (range 3–6)). Neurological deterioration after treatment occurred in 5 patients (cyanoacrylate=4, surgery=1, particles=0; P<0.001). At a median follow-up of 6 years (range 3–13 years), angiographic cure was obtained in 11/61 (18%) patients (nidal type=6/53 (11%), fistulous type=5/8 (63%)). In progressive forms, neurological improvement occurred in 16/28 (57%) patients, stabilized in 9/28 (31%), and worsened in 3/28 (12%). In hemorrhagic forms, the rebleeding rate was 4/14 patient years without standard treatment, 0/322 patient years in partial iterative treatment, and 0/15 patient years in angiographically cured lesions (P=0.001).ConclusionOur study suggests that particle embolization as a firstline therapy to treat spinal cord AVMs is safe and offers long term efficacy, especially for those with small, distal, and multiple shunts. Partial occlusion of the AVM may be sufficient to prevent rebleeding, without the potential risks of complete occlusion. Particle calibration and injection technique, ‘one by one’, are critical to safety. Cyanoacrylate embolization or surgery remains necessary if particle embolization fails to occlude large shunts.
Associations of the expression levels of genes involved in CFL2b and MyHC isoform type changes in longissimus dorsi muscle of HeBao and Large White pigs (Sus scrofa) during postnatal growth
Authors: Zhu Hongyan , Yang Huixin , Zhao Wei , Su Yuhong , Tian Yumin 
Published: July 2018

This study aimed to compare the patterns of postnatal transformation of myosin heavy chain (MyHC) isoform types in the longissimus dorsi (LD) muscle between HeBao (HB) and Large White (LW) pigs, and assess the association of porcine cofilin2b (CFL2b) mRNA abundance with changes of myofiber type composition. The four MyHC isoforms (MyHC-1, -2a, -2b, and -2x) of the LD muscle were assessed for mRNA levels in 28 HB and 28 LW pigs by reverse transcription-quantitative polymerase chain reaction (RT-qPCR). The associations of CFL2b mRNA expression and myofiber type (MyHC-1, -2a, -2b, and -2x) changes were analyzed by RT-qPCR. Although the mRNA expression patterns of MyHCs were different between the two breeds, they had similar expression levels. During postnatal growth, relative CFL2b abundance was gradually increased, with dramatic changes observed after 90 d between the two breeds (P < 0.01). Further analysis revealed significant positive correlations of CFL2b gene expression with MyHC-1/slow (HB: r = 0.871), MyHC-2b [LW: r = 0.881 (P < 0.01)], and MyHC-2x (HB: r = 0.795, LW: r = 0.814), and a significant negative correlation with MyHC-1/slow [r = −0.938 (P < 0.01)] in LW. No significant associations of CFL2b expression with MyHC-2a (HB: r = −0. 195, r = −0.697) and MyHC-2b (HB: r = 0.493) were found. Our findings suggested that HB pigs had different muscle development mechanisms in the LD muscle compared with LW, and the CFL2b expression difference could affect the levels of myofiber types which could account for meat quality differences. HB pigs possessed less glycolytic, with more oxidative metabolism and better meat quality traits compared with LW pigs at different growth stages.
Bjorken sum rule in QCD frameworks with analytic (holomorphic) coupling
Authors: Ayala César , Cvetič Gorazd , Kotikov Anatoly V. , Shaikhatdenov Binur G. 
Published: July 2018

We investigate the polarized Bjorken sum rule (BSR) in three approaches to QCD with analytic (holomorphic) coupling: Analytic Perturbation Theory (APT), Two-delta analytic QCD (2[Formula: see text]anQCD) and Three-delta lattice-motivated analytic QCD in the three-loop and four-loop MOM scheme (3l3[Formula: see text]anQCD, 4l3[Formula: see text]anQCD). These couplings do not have unphysical (Landau) singularities, and have finite values when the transferred momentum goes to zero, which allows us to explore the infrared regime. With the exception of APT, these theories at high momenta practically coincide with the underlying perturbative QCD (pQCD) in the same scheme. We apply them in order to verify the Bjorken sum rule within the range of energies available in the data collected by the experimental JLAB collaboration, i.e. [Formula: see text] and compare the results with those obtained by using the perturbative QCD coupling. The results of the new frameworks with respective couplings (2[Formula: see text] and 3[Formula: see text]) are in good agreement with the experimental data for [Formula: see text] already when only one higher-twist term is used. In the low-[Formula: see text] regime [Formula: see text], we use [Formula: see text]PT-motivated expression or an expression motivated by the light-front holography (LFH) QCD used earlier in the literature.
Harmonization of the Genetic Code Effectively Enhances the Recombinant Production of the Major Birch Pollen Allergen Bet v 1
Authors: Asam Claudia , Roulias Anargyros , Parigiani Maria A. , Haab Astrid , Wallner Michael , Wolf Martin , Briza Peter , Bohle Barbara , Ferreira Fatima , Hauser Michael 
Published: July 2018

<b><i>Background:</i></b> Enhancing the quality and yield of protein production in heterologous expression systems is an important issue for developing new biopharmaceuticals. It has been shown that the dynamics of protein folding is influenced by codon frequencies. As codon usage frequencies are species specific, this can affect heterologous protein expression. In this respect, “codon harmonization,” that is, the usage of synonymous codons with usage frequencies in the host resembling the usage frequencies in the native organism, is a promising strategy. As recombinant proteins are important tools in the area of allergy research, we investigated in this study the influence of codon harmonization on the production of the major birch pollen allergen Bet v 1.0101. <b><i>Methods:</i></b> To accomplish this task, parallel production of several batches of rBet v 1, BWT, together with a harmonized variant, BH, was applied. The expression yield of soluble and insoluble protein was assayed via densitometric analysis of ­SDS-PAGEs for every batch. The quality of purified proteins was assessed with a variety of physicochemical methods including mass spectrometry, circular dichroism, dynamic light scattering, Fourier transform infrared spectroscopy, in vitro degradation, and 1-anilino-8-naphthalene sulfonate-binding assays. Patients’ IgE reactivity was tested in enzyme-linked immunosorbent assays and rat basophil mediator release experiments. <b><i>Results:</i></b> No significant differences in the ligand-binding capacity and secondary structure elements, as well as, in immunological assays could be found; however, the production yield was drastically increased for BH. <b><i>Conclusion:</i></b> We could show that codon harmonization is a powerful method to enhance protein yields in heterologous expression systems and should be considered especially for difficult-to-express proteins.
Haemodialysis with Tinzaparin Versus Dialysate Citrate as Anticoagulation
Authors: Mahmood Dana , Stegmayr Bernd G. 
Published: July 2018

Anticoagulation with citrate-containing haemodialysate (cHD) is an alternative to tinzaparin haemodialysate (tHD). The study investigated whether cHD would differ when changed from tHD. The same 18 patients were their own controls followed up with cHD for 5 months. LDL-cholesterol decreased at the end of a cHD session (<i>p</i> = 0.01). Neutrophils (<i>p</i> = 0.013) and monocytes (<i>p</i> = 0.007) dropped more during a cHD session. During the follow-up period of cHD, approximately 50% needed additional tinzaparin. Before the cHD session could start, there was a lower total cholesterol at 2 weeks (<i>p</i> = 0.014) and LDL-cholesterol at 1 month (<i>p</i> = 0.011) versus an increase of LDL at 5 months (<i>p</i> = 0.02). Only patients without additional tinzaparin had a reduction of ­C-reactive protein (CRP) at 2 months of cHD (<i>p</i> &#x3c; 0.05) but not later. Solely cHD seems possible only in half of the patients. A greater reduction in granulocytes and monocytes during cHD indicates a more extensive blood membrane interaction, while CRP may be lower.
Revolucionários, ditadura e ruínas ao som de Villa-Lobos
Authors: Alvim Luíza Beatriz 
Published: July 2018

Partimos de conceitos de Walter Benjamin e analisamos, nos filmes O desafio (Paulo César Saraceni, 1965), Terra em transe (Glauber Rocha, 1967) e Os herdeiros (Carlos Diegues, 1970), as sequências com música de Villa-Lobos que evocam tanto a ideia da história como catástrofe quanto o filme Deus e o diabo na terra do sol (Glauber Rocha, 1964), com o qual tais filmes se relacionam também pelo elemento do travelling. Porém, diferentemente da utopia do filme de 1964, feito antes do Golpe Militar, a instalação da ditadura traz para os personagens idealistas o sentimento catastrófico, que, a partir de Benjamin, pode ser entendido também como potência.
Reflexões sobre a Cinemateca do Museu de Arte Moderna do Rio de Janeiro na virada dos anos 1960 aos 1970
Authors: Núñez Fabián 
Published: July 2018

A gestão de Cosme Alves Netto à frente da Cinemateca do Museu de Arte Moderna do Rio de Janeiro (MAM-RJ) ficou celebrizada pela importante atuação cultural que a instituição exerceu na época. É possível afirmar que sua administração marca o começo de uma nova fase da Cinemateca desse museu. Este artigo visa tecer reflexões sobre as ações da Cinemateca do MAM-RJ durante a Ditadura Militar brasileira (1964-1985), em particular, na virada dos anos 1960/1970.
Tipping Point Challenges in International Economic Disputes
Authors: Claussen Kathleen 
Published: July 2018

Abstract
This article reviews two critical “tipping point” moments in the evolution of international economic law, so-called given the overwhelming response by the international economic law community in each instance suggesting that the moment ought not be repeated as it called into question foundational tenets of the dispute resolution system. In each instance, an adjudicator was dismissed on the basis of his past decision-making, bringing into sharper focus questions about the mandate of the adjudicator and the checks and balances in relation to the adjudicatory role. This article surveys the availability of ethical or other doctrines to guide arbitrators in this respect and calls for change in the interest of preserving the legitimacy of the international economic law adjudicatory systems.
Hold on to Your Hat! Issue Conflicts in the Investment Court System
Authors: Dias Simões Fernando 
Published: July 2018

Abstract
Since 2015, the European Commission (EC) has been advocating the establishment of an investment court system (ICS). A key aspect of the proposal is the creation of the strictest ethical standards ever seen in the field of investor-state arbitration. The exercise of functions as an arbitrator does not traditionally require exclusivity, and many lawyers offer their services in the market in other capacities. This situation is described as the “double hat” phenomenon and is seen as one of the most frequent moral hazards in investment arbitration. Both the Comprehensive Economic Trade Agreement (CETA) and the Commission’s investment chapter proposal for the Transatlantic Trade and Investment Partnership (TTIP) prohibit adjudicators from acting as legal counsel in other investment dispute cases. This article discusses the potential advantages and drawbacks of the EC’s approach to the “multiple hat” problem and their potential impact on the investment arbitration system as a whole.
Impulsivity predicts illness severity in long-term course of bipolar disorder: A prospective approach
Authors: Rote Jonas , Dingelstadt Alice-Mai-Ly , Aigner Annette , Bauer Michael , Fiebig Jana , König Barbara , Kunze Johanna , Pfeiffer Steffi , Pfennig Andrea , Quinlivan Esther , Simhandl Christian , Stamm Thomas J 
Published: July 2018

Background: Bipolar disorder is a common, severe and chronic mental illness. Despite this, predictors of illness severity remain poorly understood. Impulsivity is reported to be associated with bipolar disorder and aggravating comorbidities. This study therefore sought to examine the predictive value of impulsivity for determining illness severity in euthymic bipolar disorder patients. Methods: Baseline trait impulsivity of 120 bipolar euthymic patients (81 bipolar disorder I [68%], 80 female [67%]) and 51 healthy controls was assessed using Barratt Impulsiveness Scale 11. The impact of impulsivity on illness severity (measured with morbidity index) was prospectively tested in 97 patients with sufficient follow-up data (average observation time: 54.4 weeks), using linear regression analysis. Results: Barratt Impulsiveness Scale 11 total (β = 0.01; p < 0.01) and in particular Barratt Impulsiveness Scale 11 attentional subscale scores (β = 0.04; p < 0.001) predicted illness severity in bipolar disorder, while controlling for other clinical variables. Only age at onset persisted as an additional, but less influential predictor. Barratt Impulsiveness Scale 11 total scores and Barratt Impulsiveness Scale 11 attentional subscale scores were significantly higher in euthymic patients compared to controls. This was not observed for the motor or non-planning subscale scores. Limitations: The average year-long observation time might not be long enough to account for the chronic course of bipolar disorder. Conclusion: Trait impulsivity and particularly attentional impulsivity in euthymic bipolar patients can be strong predictors of illness severity in bipolar disorder. Future studies should explore impulsivity as a risk assessment for morbidity and as a therapeutic target in bipolar disorder patients.
Protocol for N-of-1 trials proof of concept for rehabilitation of childhood-onset dystonia: Study 1
Authors: Gimeno Hortensia , Polatajko Helene J. , Cornelius Victoria , Lin Jean-Pierre , Brown Richard G. 
Published: July 2018

Background. Hyperkinetic movement disorders (HMD) are a heterogeneous group of neurological conditions among which dystonia is the predominant disorder and dyskinetic cerebral palsy the largest secondary dystonia group. Currently, there are no evidence-based, non-medical management options for childhood HMD. The Cognitive Orientation to daily Occupational Performance (CO-OP) Approach is a task-oriented, performance-based intervention that focuses on participation. Purpose. This paper reports the protocol for a proof-of-concept study to assess feasibility and preliminary evidence regarding efficacy of CO-OP for HMD following deep brain stimulation (DBS). Method. A series of N-of-1 trials with replications will be conducted with children, ages 6 and 21 years with HMD and DBS as indicated by the Manual Ability Classification System. Ten individualized CO-OP sessions, with multiple baselines before, during, and after, will be completed. The primary outcome measures are the Performance Quality Rating Scale and the Assessment of Motor and Process Skills. Outcome data will be plotted over time for each participant and supplemented with graph statistical analysis and effect size estimates. Implications. A written protocol will be developed based on evidence and feedback incorporating any changes to the CO-OP intervention for children and young people with HMD, as per the Medical Research Council’s Framework for Complex Interventions.
Protocol for N-of-1 trials with replications across therapists for childhood-onset dystonia rehabilitation: Study 2
Authors: Gimeno Hortensia , Polatajko Helene J. , Cornelius Victoria , Lin Jean-Pierre , Brown Richard G. 
Published: July 2018

Background. Currently, no evidence-based rehabilitation interventions are available for hyperkinetic movement disorders (HMD), including dyskinetic cerebral palsy (CP). Among these highly heterogeneous disorders, dystonia is the predominant disorder. The Cognitive Orientation to daily Occupational Performance (CO-OP) Approach—a task-oriented, performance-based intervention to enable participation—is currently being evaluated for its potential as an intervention option. Purpose. This paper reports the protocol for the second of two studies designed to evaluate the potential of CO-OP to improve functional outcomes for individuals with HMD following deep brain stimulation (DBS). This second study is a systematic replication across multiple treating therapists from multiple centres. Method. Systematic replications will be used across centres and treating therapists trained in the CO-OP, using a series of randomized multiple-baseline N-of-1 trials. Participants will be ages 6 to 21 years with HMD and DBS as indicated by the Manual Ability Classification System. Data collection will involve multiple data points collected at baseline, during intervention, and after intervention. The intervention will involve occupation-based goal setting followed by 10 individualized CO-OP sessions. The primary outcome measures are the Performance Quality Rating Scale and the Canadian Occupational Performance Measure. Outcome data will be plotted over time for each participant and supplemented with graph statistical analysis and estimate size effect for N-of-1 trials. Implications. The results of this study will help to inform future training procedures and future clinical trials.
The Equity Lens for Occupational Therapy: A program development and evaluation tool
Authors: Restall Gayle J. , MacLeod Schroeder Natalie J. , Dubé Charmayne D. 
Published: July 2018

Background. Occupational therapists value the principles of health and health care equity and often face challenges addressing inequities within the systems in which they work. Purpose. We present the Equity Lens for Occupational Therapy (ELOT), a framework to provide a practical starting point for reflecting on equity issues and the ways inequities are enacted in daily practice. Key Issues. Building on an existing occupational therapy practice model and well-established program development and evaluation processes, we overlay an equity lens. The lens provides a structured way to critically reflect on occupational therapy programs within their contexts and develop action strategies to prevent or redress inequities. Implications. Taking action on the multiple ways that inequities can be embedded in occupational therapy programs within health and social systems can be a daunting task. The ELOT provides a systematic way to stimulate critical reflection and dialogue, examine practice, focus social advocacy, and take action.
What do we know about technologies for dementia-related wandering? A scoping review
Authors: Neubauer Noelannah A. , Lapierre Nolwenn , Ríos-Rincón Adriana , Miguel-Cruz Antonio , Rousseau Jacqueline , Liu Lili 
Published: July 2018

Background. Occupational therapists use technologies to manage wandering-related risks to promote safety and independence among individuals with dementia living in the community. Purpose. The purpose of this review was to examine types of technologies used to manage wandering behaviour. Method. Using a modification of Arksey and O’Malley’s methodology, we systematically searched peer-reviewed and grey literature on technologies used in home or supportive care environments for persons with dementia at risk for wandering. Data from the studies were analyzed descriptively. Findings. The literature described 83 technologies. Nineteen devices were clinically tested. Interventions ranged from alarm products to mobile locator devices. Benefits included reductions in risk and caregiver burden. Implications. Occupational therapy strategies include technologies to enhance function in persons with dementia. Technologies can also reduce risks of wandering and should be affordable. Ethical issues of the use of technology must be addressed. More research is needed to increase levels of evidence.