bluuebunny/crossref_metadata_2025_split huggingface dataset:
Presence of causative mutations affecting prolificacy in the Noire du Velay and Mouton Vendéen sheep breeds
Authors: Chantepie L. , Bodin L. , Sarry J. , Woloszyn F. , Ruesche J. , Drouilhet L. , Fabre S. 
Published: July 2018

AbstractFor many decades, prolificacy has been selected in meat sheep breeds as a polygenic trait but with limited genetic gain. However, the discovery of major genes affecting prolificacy has changed the way of selection for some ovine breeds implementing gene-assisted selection as in the French Lacaune and Grivette meat breeds, or in the Spanish Rasa Aragonesa breed. Based on statistical analysis of litter size parameters from 34 French meat sheep populations, we suspected the segregation of a mutation in a major gene affecting prolificacy in the Noire du Velay and in the Mouton Vendéen breeds exhibiting a very high variability of the litter size. After the genotyping of mutations known to be present in French sheep breeds, we discovered the segregation of the FecLL mutation at the B4GALNT2 locus and the FecXGr mutation at the BMP15 locus in Noire du Velay and Mouton Vendéen, respectively. The frequency of ewes carrying FecLL in the Noire du Velay population was estimated at 21.2% and the Mouton Vendéen ewes carrying FecXGr at 10.3%. The estimated mutated allele effect of FecLL and FecXGron litter size at +0.4 and +0.3 lamb per lambing in Noire du Velay and Mouton Vendéen, respectively. Due to the fairly high frequency and the rather strong effect of the FecLL and FecXGr prolific alleles, specific management programmes including genotyping should be implemented for a breeding objective of prolificacy adapted to each of these breeds.
Neurotensin and Dynorphin Bi-Directionally Modulates CeA Inhibition of oval BNST Neurons in Male Mice
Authors: Normandeau CP , Torruella Suárez ML , Sarret P , McElligott ZA , Dumont EC 
Published: July 2018

AbstractNeuropeptides are often co-expressed in neurons but their neurophysiological effects are commonly studied individually. Multiple neuropeptides may therefore be simultaneously released to coordinate proper neural circuit function. Here, we triggered the release of endogenous neuropeptides in brain slices from male mice to better understand the modulation of central amygdala (CeA) inhibitory inputs onto oval (ov) BNST neurons. We found that locally-released neurotensin (NT) and dynorphin (Dyn) antagonistically regulated CeA inhibitory inputs onto ovBNST neurons. NT and Dyn respectively increased and decreased CeA-to-ovBNST inhibitory inputs through NT receptor 1 (NTR1) and kappa opioid receptor (KOR). Additionally, NT and Dyn mRNAs were highly co-localized in ovBNST neurons suggesting that they may be released from the same cells. Together, we showed that NT and Dyn are key modulators of CeA inputs to ovBNST, paving the way to determine whether different conditions or states can alter the neuropeptidergic regulation of this particular brain circuit.
Uncertainty as opportunity: the challenge of project based careers
Authors: Lloyd-Walker Beverley , Crawford Lynn , French Erica 
Published: July 2018

Purpose
Current literature acknowledges the growth of careers in project management. The purpose of this paper is to provide a better understanding of the characteristics of those who choose and continue in project-based careers.

Design/methodology/approach
Using social cognitive career theory as the lens to explore project management career journeys, 74 project practitioners were interviewed from across three broad industry sectors. A qualitative research approach was utilized and Atlas.ti was used to analyze and categorize the interview data collected.

Findings
Those who choose to continue in project-based roles demonstrate high levels of self-efficacy and coping efficacy and see uncertainty as opportunity. They value challenge, flexibility and variety and take responsibility for their own career progression. Desire for employment security may vary according to personal circumstance. These findings are of value to employers in guiding selection and retention of people for project roles.

Research limitations/implications
This is a qualitative and exploratory study covering only three industry sectors and results are not generalizable. SCCT was found useful as a lens for understanding the nature of project-based careers.

Practical implications
Findings of this research provide valuable guidance for employers and HR practitioners in project-based organizations. For practitioners the study provides a useful framework for reflecting upon their own careers in projects.

Social implications
The nature of careers is changing. Project-based careers are indicative of this change. This study therefore provides insight into an evolving phenomenon.

Originality/value
This study expands our understanding of careers in projects, going beyond technical skill development to gain a deeper understanding of personal attributes that contribute to selection into and retention in project-based careers.
Optimization-based gait planning and control for biped robots utilizing the optimal allowable ZMP variation region
Authors: Zhu Hongbo , Luo Minzhou , Li Jingzhao 
Published: July 2018

Purpose
The purpose of this study is to present an optimization-based gait planning method for biped robots according to the conditions of terrain, which takes fully the relationship between walking stability margin and energy efficiency into account.

Design/methodology/approach
First, the authors newly designed a practical gait motion synthesis algorithm by using the optimal allowable zero moment point (ZMP) variation region (OAZR), which can generate different gait motions corresponding to different terrains based on the modifiability of ZMP in lateral (y-axis) direction. Second, an effective gait parameter optimization algorithm is performed to find the optimal set of key gait parameters (step length, duration time of gait cycle, average height of center of mass (CoM), amplitude of the vertical CoM motion and double support ratio), which maximizes either the walking stability margin or the energy efficiency with certain walking stability margin under practical constraints (mechanical constraints of all joint motors, geometric constraints, friction force limit and yawing moment limit) according to the conditions of terrain. Third, the necessary controllers for biped robots have been introduced briefly.

Findings
The experiment data and results are described and analyzed, showing that the proposed method was verified through simulations and implemented on a DRC-XT biped robot.

Originality/value
The main contribution is that the OAZR has been defined based on AZR, which could be used to plan and generate the various feasible gait motions to help a biped robot to adapt effectively to various terrains.
When kids are the last to know: embodied tensions in surprising children with family vacations
Authors: Drenten Jenna 
Published: July 2018

Purpose
Surprise family vacations have become increasingly prevalent in today’s digitally mediated consumer culture. Drawing on a performance-based view of tourism, this paper aims to explore the performance practices and embodied experiences by which young consumers are the recipients of last-minute surprise vacations.

Design/methodology/approach
YouTube offers a space for examining surprise family vacations, as captured in real time by consumers. The visual elements and verbal discourses of 139 surprise family vacation reveal videos were analyzed using a hermeneutical approach.

Findings
Findings suggest that surprise family vacations are characterized by three performance practices in which embodied tensions arise between normative expectations and unanticipated experiences: executing the reveal (scripted act versus improvised act), announcing the destination (absolute ideal versus relative ideal) and reacting to the surprise (initial acceptance versus initial rejection).

Research limitations/implications
By exploring a phenomenon in which children’s anticipation for a vacation is largely absent or limited, surprise family vacations reveal culturally idealized norms and performative practices in family tourism. Positioning a family vacation as an offering or surprise for the children is distinct from previous research, which suggests family vacations are co-created. Children of all ages experience tourism-related stresses and anxieties.

Practical implications
The primary practical contribution for marketers lies in revealing how the material and performative practices of a family vacation begins even before a family enters its tourist destination. Service providers and retailers may provide offerings for families to support surprise family vacations, particularly in an increasingly digital culture. This study also reveals opportunities for parents to strategically discuss surprise vacations with their kids.

Originality/value
This study captures the liminal moment in which a child’s tourism journey begins. By using YouTube as a resource for digital ethnography, researchers can better understand how families discuss, negotiate and mediate tourism-oriented concepts, through their lived experiences.
Prognostic role of soluble ST2 in acute coronary syndrome with diabetes
Authors: Jha Durga , Goenka Luxitaa , Ramamoorthy Thilagavathi , Sharma Masum , Dhandapani Vellala E. , George Melvin 
Published: July 2018

AbstractBackgroundAcute coronary syndrome (ACS) patients are at an increased risk of major adverse cardiovascular events (MACE). The objective of our study was to assess whether cardiac biomarker like soluble ST2 (sST2) can predict MACE among ACS patients with diabetes.Materials and MethodsA total of 122 patients with ACS were included in the study. sST2 level in blood plasma samples was quantified using enzyme‐linked immunosorbent assay (ELISA). Prognostic utility of sST2 for the primary outcome of MACE which included mortality, rehospitalization due to chest pain, unstable angina, recurrent myocardial infarction (MI) and stroke, was assessed during follow‐up.ResultsThe median follow‐up period was of 180 days. ROC (receiver operating characteristic) curve demonstrated that elevated levels of sST2 were able to predict mortality, and MACE in ACS patients, along with increased risk of occurrence of MACE and mortality in ACS patients having diabetes. Kaplan‐Meier plots revealed a significant increase in the occurrence of MACE in diabetic ACS patients (P = 0.006; by log‐rank test). Cox regression analysis revealed that sST2 is not an independent predictor of mortality and MACE in ACS patients having diabetes; however, high sST2 level was found to be a predictor of MACE in all ACS subjects in the fully adjusted model with a hazard ratio (HR) of 5.8 (P = 0.032).ConclusionThe current study indicates that elevated levels of sST2 might be a suitable biomarker to evaluate the risk of future adverse cardiovascular events in ACS patients with diabetes.
Anti‐insect defenses of Achnatherum robustum (sleepygrass) provided by two Epichloë endophyte species
Authors: Shymanovich Tatsiana , Faeth Stanley H. 
Published: July 2018

AbstractMany pooid grasses (Poaceae) harbor Epichloë species (Hypocreales), endophytic fungi that often produce toxic alkaloids which may provide anti‐insect protection for their hosts. Two natural populations of Achnatherum robustum (Vasey) (sleepygrass), in the Lincoln National Forest, Cloudcroft, and Weed (NM, USA), are infected with the endophyte species Epichloë funkii (KD Craven & Schardl) JF White and Epichloë sp. nov. We tested whether: (1) these endophytes affect survival, growth, and development of the insect herbivore Spodoptera frugiperda (JE Smith) (Lepidoptera: Noctuidae) (fall armyworm), (2) larval diets alter adult fecundity (assessed as number of larvae or eggs produced by females and number of spermatophores that males transfer to females when enclosed in pairs within each feeding group), and (3) infections affect leaf consumption in larval no‐choice and choice experiments. Individual larvae were reared on Epichloë infected vs. uninfected clipped leaves from the Cloudcroft and Weed population plants. Overall, armyworm survival was not affected when fed infected sleepygrass from either population. However, larvae that fed on Weed‐infected plants were smaller and had longer development than larvae that fed on uninfected and Cloudcroft‐infected plants. Males fed on Weed‐infected leaves had reduced mating success. Interestingly, pupal mass increased when larvae fed on either the infected leaf types. However, heavier females from both infected diets did not lay more eggs than lighter females from uninfected diets. In a no‐choice test, larvae on Weed‐infected plants diet consumed more leaf biomass than larvae from three other groups. In choice tests, larvae avoided feeding on leaves infected with either of the endophytes relative to uninfected leaves. Thus, the two Epichloë may provide direct protection to sleepygrass from insect herbivory by deterrence. The Weed population endophyte may provide stronger indirect protection than the Cloudcroft endophyte by reducing insect fitness or increasing risks of predation and parasitism through delayed development, even though larvae may consume more leaf biomass.
Clinical follow‐up of 411 patients with relapsing and progressive multiple sclerosis 10 years after discontinuing mitoxantrone treatment: a real‐life cohort study
Authors: Chartier N. , Epstein J. , Soudant M. , Dahan C. , Michaud M. , Pittion‐Vouyovitch S. , Guillemin F. , Debouverie M. , Mathey G. 
Published: July 2018

Background and purposeMitoxantrone (MITOX) has been used to treat patients with aggressive multiple sclerosis (MS) for decades. We aimed to describe the effectiveness and adverse events over 10 years post‐MITOX in patients with relapsing and progressive MS from an exhaustive real‐life database.MethodsData from patients who received MITOX before 1 January 2006 were collected from the MS Lorraine registry. Expanded Disability Status Scale (EDSS) scores and annual relapse rates (ARRs) year by year during follow‐up and the year prior to MITOX were compared. Time to the first relapse and a 1‐point increase in EDSS score were used in Cox multivariate models to find associations with potential predictive factors.ResultsA total of 411 patients were included. The ARR for the 155 relapsing patients had decreased from 2.0 (SD 1.20) the year before treatment to 0.3 (SD 0.31) by year 10 (P < 0.0001). The EDSS score increased from 2.8 (SD 1.44) to 4.8 (SD 1.90) by year 10 (P < 0.0001). A high ARR at MITOX initiation was associated with a longer time to a 1‐point increase in EDSS score (hazard ratio, 0.81; 95% confidence interval, 0.67–0.99; P = 0.04). The EDSS score in 256 progressive patients increased from 5.0 (SD 1.33) to 6.5 (SD 1.26) by year 10 (P < 0.0001). We identified four cases of acute myeloid leukemias.ConclusionsPatients with the most active forms of MS are the most likely to benefit from MITOX in the long term.
Study of the possible link of 25‐hydroxyvitamin D with Epstein–Barr virus and human herpesvirus 6 in patients with multiple sclerosis
Authors: Pérez‐Pérez S. , Domínguez‐Mozo M. I. , García‐Martínez M. Á. , Aladro Y. , Martínez‐Ginés M. , García‐Domínguez J. M. , López de Silanes C. , Casanova I. , Ortega‐Madueño I. , López‐Lozano L. , Torrejón M. J. , Arroyo R. , Álvarez‐Lafuente R. 
Published: July 2018

Background and purposeAlthough the causes of multiple sclerosis (MS) remain partially unknown, environmental and genetic factors are thought to play a role in its aetiopathogenesis. Hypovitaminosis D, Epstein–Barr virus (EBV) and human herpesvirus 6 (HHV‐6) infections have been described as possible MS triggers. Our aim was to analyse the possible link between 25‐hydroxyvitamin D [25(OH)D] and viruses in patients with MS.MethodsWe included 482 patients with MS in a 2‐year study. Serum samples were collected to analyse 25(OH)D levels and, according to sample availability, antibody titres against EBV and HHV‐6 by enzyme‐linked immunosorbent assay. DNA was extracted from blood in order to analyse EBV and HHV‐6 viral load by quantitative real‐time polymerase chain reaction and to genotype MS‐related single nucleotide polymorphisms (rs3135388, rs2248359 and rs12368653) when possible.ResultsThe 25(OH)D levels were significantly higher in the first semester of the year than in the second. Carriers of the risk allele rs2248359‐C showed lower 25(OH)D levels than non‐carriers. For EBV, viral load was significantly higher when 25(OH)D levels were low, demonstrating an inverse correlation between 25(OH)D levels and EBV load.ConclusionsThe 25(OH)D levels could be involved in the regulation of EBV replication/reactivation in patients with MS.
Initial Offer Precision and M&A Outcomes
Authors: Hukkanen Petri , Keloharju Matti 
Published: July 2018

AbstractBuilding on recent research in social psychology, this paper analyzes the link between the precision of initial cash offers and mergers and acquisition (M&A) outcomes. About one‐half of the offers are made at the precision of one or five dollars per share, while an additional one‐third are made at the precision of a half dollar or one quarter. The practice of making offers at round price‐per‐share levels is associated with a higher purchase price for target shares and a lower probability of deal completion.
Diagnostic ability of a smart phone app (injured tooth) in diagnosing traumatic injuries to the teeth – a multicentre analysis
Authors: Mohan Anusha , Agarwal Tanvi , Cherian Theresa Sam , Muthu Murugan Satta , Balasubramanian Suganya , Subbalekshmi Natesh , Saikia Ankita , Goswami Mridula , Sharma Akhilesh , Subramanian Priya , Johar Smriti , Bazaz Negar 
Published: July 2018

BackgroundDental trauma is not uncommon. The initial management provided at the time of injury is critical in predicting prognosis. However, initial management depends on correct diagnosis. Recently an App named ‘Injured Tooth’ was made available to diagnose traumatic injuries to the teeth and supporting structures.AimTo test the diagnostic ability of the Injured Tooth App compared with the conventional method of diagnosing traumatic injuries to the teeth.DesignA cross‐sectional study was conducted at three different centres with 176 patients aged 0–15 years, having 201 injured teeth. Diagnosis of the injured teeth in these children at every centre was done independently by one experienced faculty using the traditional method and by a student using the Injured Tooth App.ResultsInjured Tooth App gave a correct diagnosis for 197 teeth included in the study. Statistical analysis showed that there was good agreement (Kappa = 0.973) between the diagnosis given by the App and the experienced faculty.ConclusionsThe study found that the diagnosis given by the Injured Tooth App was in good agreement with the diagnosis given by an experienced faculty. Hence, the App can be successfully used by dental students to arrive at diagnosis.
“Put bluntly, they are targeted by the worst creeps society has to offer”: Police and professionals' views and actions relating to domestic violence and women with intellectual disabilities
Authors: McCarthy Michelle , Bates Claire , Triantafyllopoulou Paraskevi , Hunt Siobhan , Milne Skillman Karen 
Published: July 2018

AbstractBackgroundLittle is known about the attitudes and practices of key personnel towards the domestic violence experienced by women with intellectual disabilities.MethodAn online survey was conducted of Police officers and health and social care professionals. A total of 717 Police and other professionals across a wide variety of UK sites responded. Research questions were focussed on direct experience, attitudes and responses.ResultsApproximately half of all respondents had direct experience of working with a woman with intellectual disabilities who had been through domestic violence. Professionals were more likely than the Police to see women with intellectual disabilities as being especially vulnerable. The majority of both professionals and Police believed women with intellectual disabilities were deliberately targeted by violent and abusive men.ConclusionsMore training is needed for both the Police and health and social care professionals specifically in domestic violence as it affects women with intellectual disabilities.
Nonsurgical treatment of earlobe aging in Mowlavi stages I and II earlobe ptosis with Hyaluronic acid fillers
Authors: Di Gregorio Carlo , D'Arpa Salvatore 
Published: July 2018

SummaryBackgroundEarlobe deflation caused by fat atrophy is normally treated with lipofilling, mostly in the context of facelift surgery. In this report, we aim at reporting on Hyaluronic Acid injections to treat earlobe deflation.Materials and Methods16 Mowlavi Grade I and II patients were treated with HA injections, followed by molding to shape the lobule.ResultsEffective correction, lasting 14 months on average, is achieved. Five patients needed a touch‐up procedure after 4‐6 months to improve the result.ConclusionsEarlobe augmentation with HA is an ideal option for correction of earlobe atrophy in cases of Mowlavi Grades I and II ptosis. Long‐lasting (about 14 months) correction is achieved with no downtime.
Factors associated with emergency cesarean delivery during induction of labor in nulliparous women aged 35 years or older at term
Authors: Nakano Takahiro , Muto Haruka , Ishii Keisuke , Hayashi Shusaku , Okamoto Yoko , Mitsuda Nobuaki 
Published: July 2018

AbstractAimTo examine the intrapartum cesarean delivery rate following failure of induction of labor (IOL) as well as risk factors associated with failed IOL among nulliparous women of advanced maternal age (AMA).MethodsThis was a retrospective cohort study conducted at a single perinatal care center. We retrospectively reviewed the medical records of nulliparous AMA women (aged 35 years or older) with singleton vertex pregnancy who underwent IOL at term. Data regarding maternal baseline characteristics and pregnancy course, including complications during pregnancy and maternal status at time of IOL, were collected. Rate of emergency cesarean section (eCS) as well as risk factors associated with failed IOL were investigated by means of logistic regression analysis.ResultsAmong 234 women included in this study, 103 (44%) had failed IOL and delivered by eCS. Hypertensive disorder during pregnancy (adjusted odds ratio [aOR], 2.01; 95% confidence interval [CI], 1.0–4.12; P = 0.025) and unfavorable cervical status (aOR, 1.92; 95% CI, 1.08–3.41; P = 0.038) were identified as independent risk factors for failed IOL.ConclusionIOL failed in 44% of nulliparous AMA women. Hypertensive disorder and immature cervical status should be considered as independent risk factors for eCS among such women.