bluuebunny/crossref_metadata_2025_split huggingface dataset:
A randomised study to evaluate the efficacy of isotretinoin, electrodessication and comedone extraction in the treatment of comedonal acne
Authors: Ramya Kuraganty , Devi Bakuru Gayatri , Gopal K. V. T. , Narayana Rao T. 
Published: July 2019

<p class="abstract"><strong>Background:</strong> Comedonal acne commonly seen in adolescents and young patients which is refractory to standard treatments. This study is being undertaken to determine the efficacy and adverse effects of oral isotretinoin, electrodessication and comedone extraction in patients of comedonalacne.</p><p class="abstract"><strong>Methods:</strong> A total of 120 patients of comedonal acne were enrolled and randomly divided into 4 groups of 30 patients each. Group A, B, C and D patients were treated with isotretinoin (20 mg daily), electrodessication, comedone extraction (4 weeks interval) and topical antibiotic daily for 12 weeks. The response in each group was assessed based on decrease in total comedonal count after 12 weeks of treatment. Statistical analysis was done using chi square test.<strong></strong></p><p class="abstract"><strong>Results:</strong> Eighty seven (72%) cases had predominantly closed comedones and 33 (27%) cases showed open comedones. After 12 weeks of treatment, more than 75% decrease in comedonal count was seen in 60% of patients in electrodessication group followed by 30% (isotretinoin), 13.3% (comedone extraction). The decrease in total number of comedone was significantly higher with electrodessication (84.4%) followed by isotretinoin (73%), comedone extraction (43.2%) and topical antibiotic (5.7%). After follow up of 3 months, recurrence of comedones was least with isotretinoin followed by comedone extraction and electrodessication.</p><p class="abstract"><strong>Conclusions:</strong> For comedonal acne, initial electrodessication followed by isotretinoin over 12 weeks gives the best outcome of quick remission and least recurrence. Electrodessication and comedone extraction are the preferred modalities in patients with predominantly closed and open comedones respectively.</p><p class="abstract"> </p>
Turismo cultural: perspectivas para a função turística em bibliotecas do Brasil
Authors: De Abreu Schamberlain Nayana , Teixeira Juliana Carolina 
Published: July 2019

O objetivo geral da pesquisa foi investigar que funções são desenvolvidas nas bibliotecas brasileiras e a sua relação com o turismo. Diante disso, como metodologia, optou-se por trabalhar com as principais bibliotecas das sete capitais brasileiras que, juntas, somam 70% do fluxo turístico brasileiro. Para o levantamento de dados em campo foram encaminhados questionários para os representantes das bibliotecas estudadas. Como resultado de pesquisa, fica claro que todas as bibliotecas desenvolvem novas funções e a visita guiada é a principal atividade que estabelece ligação do turista com o espaço. Foi constatado também que as pessoas que passam por essas bibliotecas, elas, em sua maioria, não estão sendo instigadas a conhecer e a valorizar esse patrimônio cultural e todo o seu entorno. O principal motivo dessa relação negativa tem ligação direta com a falta de políticas públicas locais ligadas ao turismo e/ou com a cultura, que acarreta uma insatisfação demonstrada por parte dos representantes de bibliotecas. Por isso, é defendido, aqui, que as bibliotecas inseridas em cidades com um fluxo de turismo relevante devem considerar a função turística como parte do convívio desse espaço.
Turismo de Base Comunitária e Produção do Espaço na Comunidade da Ilha de Deus, Recife-PE.
Authors: Silva João Paulo , Araujo Cristina Pereira de 
Published: July 2019

O presente artigo teve como objetivo discutir a relação entre turismo e produção do espaço. Para tanto, realizamos um estudo de caso na comunidade da Ilha de Deus, localizada na zona sul da cidade do Recife, capital do Estado de Pernambuco, que vem despontando no desenvolvimento do turismo de base comunitária, um modelo alternativo ao turismo convencional. Como base teórico-metodológica principal, nos apoiamos na teoria de Milton Santos sobre o espaço geográfico, realizamos visitas in loco e buscamos relacionar, na área em estudo, algumas categorias de análise propostas pelo autor: os eventos, as verticalidades, as horizontalidades e as rugosidades.
Errors in Students' Writing Composition in Simple Present Tense “MY DAILY ACTIVITY”
Authors: Fitria Tira Nur 
Published: July 2019

ABSTRACT
This research is to find out the types of error analysis found in the Students’ Writing Composition in the aspect of grammar, punctuation and spelling also is to find out the most dominant kind of error analysis found in Students’ Writing Composition in Simple Present Tense form. This study applies the quantitative and qualitative methods. This study used documentation as a method of collecting data. From the analysis of this research, it shows that the students’ error in writing composition of simple present tense consists of three aspects of writing, they are they are in grammar, punctuation and spelling. In the aspect of grammar, there are 66 data or 56.89 %, which consist of some errors in class words (part of speech) such as in in verb (25 data or 37.88 %), determiner/article (16 data or 24.24 %), preposition (15 data or 13.64 %), noun (9 data or 13.64 %) and pronoun (1 data or 1.51 %). In punctuation, there are 28 data or 28.14 %, while in spelling there are 22 data or 18.97 %.
ARANG AKTIF KULIT PISANG KEPOK DALAM MENGIKAT LOGAM BERAT TIMBAL
Authors: Patracia Dewi , Moelyaningrum Anita Dewi , Pujiati Rahayu Sri 
Published: July 2019

Aktivitas TPA dapat mencemari lingkungan sekitar, logam berat adalah cemaran yang berbahaya bagi lingkungan. Kulit pisang kepok dari Kabupaten Jember mengandung selulosa 55% yang memungkinkan dapat mengikat logam berat Pb. Tujuan penelitian ini yaitu menganalisis perbedaan kadar Pb pada kelompok tidak diberi perlakuan penambahan massa arang aktif kulit pisang 0g/200ml (P0), dengan air sumur yang diberi perlakuan penambahan massa arang aktif kulit pisang 2g/200ml (P1), 3g/200ml (P2), dan 4g/200ml (P3) dengan air sumur yang mengandung Pb selama 10 menit. Penelitian ini merupakan True Experiment dengan menggunakan metode Rancangan Acak Lengkap (RAL) dengan enam pengulangan. Setiap sampel dikontakkan air yang mengandung Pb, diaduk menggunakan magnetig stirrer dengan kecepatan 300 rpm selama 10 menit, kemudian dilakukan penyaringan menggunkaan kertas saring untuk memisahkan arang dengan air. Data dianalisis dengan kolmogorof smirnof dilanjutkan dengan menggunakan uji statistik One Way Anova. Hasil menunjukkan terdapat perbedaan penurunan kadar Pb yang signifikan antara kelompok kontrol (P0), dan kelompok-kelompok perlakuan penambahan arang aktif kulit pisang kepok (P1=0,000; P2=0,000; P3=0,000). Arang aktif kulit pisang kepok terbukti secara signifikan dapat mengikat timbal (Pb) dalam air.
EFL Learner's Self-concept: Repercussions of Native Speakerism
Authors: Fallas Escobar Christian 
Published: July 2019

In Costa Rican universities, English as a foreign language (EFL) programs are often filled with practices and discourses that idealize native speakers of English and construct them as the models to follow. In these programs, instructors’ overreliance on native speaker proficiency models create unrealistic standards that can misinform EFL learners’ views of their proficiency as English speakers. As these students ‘fail’ to align their present L2 proficiency to the ideal praised in the classroom, they develop negative self-concepts, which lead them to characterize their proficiency as deficient and incomplete. In this paper, I examine tacitly validated practices and circulating narratives in two academic EFL programs in a public Costa Rican university regarding learners’ expected EFL proficiency and problematize the repercussions these unspoken expectations may have for these students’ overall self-concept as L2 speakers. In light of the results that I discuss herein, I advocate for the abandonment of the native speakerism trend that still prevails in the EFL programs in question and for the construction of EFL teaching practices that provide EFL learners with the validation they deserve for their expanding linguistic repertoire. En las universidades costarricenses, los programas de inglés como lengua extranjera están plagados de prácticas y discursos que idealizan al nativo hablante del inglés y lo posicionan como elmodelo a seguir. En estos programas, el uso constante y exclusivo de modelos nativo hablantes por parte de los profesores crean estándares poco reales que pueden distorsionar la percepción que los estudiantes tienen sobre sus capacidades en el idioma inglés. Esto debido a que cuando los estudiantes no logran alinear sus destrezas en la segunda lengua a la proficiencia que implícitamente se idealiza en la clase, estos desarrollan un auto-concepto negativo que los lleva a describir sus propias destrezas lingüísticas como deficientes e incompletas. Es por eso que en este estudio, me doy a la tarea de analizar narrativas circulantes en dos programas académicos de inglés como lengua extrajera de una universidad pública en Costa Rica, en cuanto al nivel de competencia en inglés que los estudiantes perciben se espera de ellos al terminar el programa, y problematizo las repercusiones que estas expectativas implícitas tienen en el auto-concepto de los discentes. A la luz de los resultados que aquí presento, abogo por la erradicación de la tendencia de idealizar al nativo hablante del idioma inglés que aún prevalece in los programas en cuestión y por la construcción de prácticas pedagógicas que validen las destrezas que los estudiantes desarrollan en programas de inglés como lengua extranjera.
Classification of Electrocardiogram Signals using Principal Component Analysis and Levenberg Marquardt Backpropagation for Detection Ventricular Tachyarrhythmia
Authors: Manik Astrima , Adiwijaya Adiwijaya , Utama Dody Qori 
Published: July 2019

Abstract
Ventricular Tachyarrhythmia (VT) are the primary arrhythmias which are cause of sudden death. For someone who already has symptoms of VT should immediately perform an examination of one of them by using an electrocardiogram (ECG). An electrocardiogram is a recording of the heart's electrical results in a waveform. However, limited ability in analysis and diagnosis of ECG reading is still difficult to do. Therefore, the classification of ECG signals is needed to detect a person, especially those with VT or not. In this research focuses on the classification of VT heartbeats from ECG signals by using median filter method in preprocessing, Principal Component Analysis (PCA) as feature extraction and modified Backpropagation (MBP) as classification. This research used machine learning method that is a neural network with backpropagation modification that is Levenberg Marquardt to speed up network training process. The best VT detection performance results were based on the average accuracy of the overall scheme of 91.67% with the best parameters that principal component=10 and 20, hidden neuron=4, and µ value=0.001 as well training time 1 seconds with a comparison of train data and test data that is 80:20 percent.
Keywords: Electrocardiogram, Levenberg Marquardt Backpropagation, Median filter, Principal Component Analysis, and Ventricular Tachyarrhythmia
The prognosis of type III biliary atresia with a hilar cyst on ultrasonography might not be better than that without
Authors: Shan Quan-yuan , Liu Bao-xian , Zhong Zhi-hai , Chen Hua-dong , Guo Yu , Xie Xiao-yan , Zhou Wen-ying , Jiang Hong , Zhou Lu-yao 
Published: July 2019

Abstract
Background

Biliary atresia (BA) with a hilar cyst is an uncommon variant of BA that may be misunderstood to have a relatively favorable prognosis.

Methods

A single-center retrospective review of patients that matched BA with a hilar cyst (n=27) with BA without a cyst (n=27) over a 5-years period was done. All patients were diagnosed as type III BA by histologic examination and cholangiograms.

Results

There were no significant intergroup differences between baseline characteristics and outcomes after Kasai portoenterostomy surgery in two groups. The Kaplan–Meier survival curves showed no significant difference in cumulative native liver survival rate of the two groups (p = 0.584). Of the 27 BA patients with a hilar cyst, 8 were showed the cyst communicated with the gallbladder on cholangiograms, and Kaplan-Meier survival curves indicated that the cumulative native liver survival rate was significantly shorter (P=0.045) in them than those who the cyst was not communicated with the gallbladder.

Conclusions

Type III BA with a hilar cyst had no better prognosis compared with Type III BA without a cyst. A cyst communicated with the gallbladder may be associated with a poor eventual outcome for Type III BA with a hilar cyst.
The complete guide to ADHD: nature, diagnosis, and treatment
Authors: Bölte Sven 
Published: July 2019

Abstract
I kindly received a copy of this new textbook from the authors some months ago, and now finally found the time to study it in more detail. Authors Katerina Maniadaki and Efthymios Kakouros are Professors of Developmental Psychopathology at the University of West Attica, and summarize here 25 years of clinical experience of working for children and adolescents with ADHD and relatives. Still the guide is also richly and excellently taking into account the perspective on ADHD in adulthood. The cover and foreword of the guide tells that it has already been endorsed by several recognized authorities in the field, such as Edmund Sonuga-Barke, Russell A. Barkley, Rosemary Tannock, and others which increased both my expectancies and excitement when starting to read. To make a long story short, I can sincerely recommend it to Scandinavian clinicians and researchers in the field.
INTEGRASI PENDIDIKAN, PENELITIAN, & PELAYANAN YANG BERKUALITAS DALAM ACADEMIC HEALTH SYSTEM
Authors: Pinzon Rizaldy Taslim , Merry Maria Silvia 
Published: July 2019

Pelayanan kesehatan di era ini mengalami perubahan sesuai dengan
pengaruh situasi global, kemajuan pesat di bidang informasi dan teknologi, serta
tingginya mobilitas penduduk dunia. Hal tersebut menyebabkan pelayanan
kesehatan juga terdampak dengan menghadapi berbagai tantangan, yaitu: 1) pola
penyakit yang berubah, 2) perubahan proporsi populasi dan demografi, 3)
disparitas pelayanan kesehatan dan tuntutan masyarakat. Perubahan sistem
pelayanan kesehatan di Indonesia sejak tahun 2014 dengan diberlakukannya
Jaminan Kesehatan Nasional (JKN) juga turut berandil besar dalam perubahan
pola pemberian pelayanan kesehatan yang cukup bermakna.
Interactions between Earth’s local magnetic field and cardiovascular system parameters of women, performing sedentary work, during their workweek
Authors: Nasutavičienė Deimantė , Grygieńć Sylwia , Poškaitis Vytautas , Tamulionytė Vilma , McCraty Rollin , Vainoras Alfonsas 
Published: July 2019

The aim of this research was to identify the interactions between Earth's local time varying magnetic field and cardiovascular system parameters in women, performing sedentary work, during their workweek. The tasks of research: 1. To examine the relationship between the Earth's local magnetic field and the electrocardiographic parameters of women performing sedentary work, during the workweek. 2. To examine the relationship between the Earth's local magnetic field and arterial blood pressure of women performing sedentary work, during the work week. The methods used: electrocardiographic monitoring and arterial blood pressure measurement. The Earth's magnetic field data was obtained using a magnetometer located in the town of Baisogala. Every female was assessed four times: before and after work on Monday, before and after work on Friday of the same week. Participants of the research: the research group consisted of 21 females who perform sedentary work (average age ± SD – 50.1±9.5 years). Conclusions of the research: 1. The most significant correlations between local GMF and ECG and arterial blood pressure parameters were found with the low frequency field, the most often in SDelta [0-3.5] Hz and STheta [3.5-7] Hz bands. 2. The correlations between ECG parameters (RR, JT and QRS intervals ant ST amplitude) during the workweek changed from negative to positive, which appears to be associated with fatigue influence on person sensitivity to local GMF. 3. Systolic and diastolic arterial blood pressure changed in different ways. The correlations between local GMF and diastolic arterial blood pressure were especially pronounced. 4. All ECG and arterial blood pressure parameters showed great variability in correlation with local GMF. It can be associated with changing human sensitivity to GMF due to increasing fatigue.
A novel measurement method of toe debris thickness for bored piles based on one-dimensional wave theory
Authors: Xu Zhijun , Liu Jun , Yuan Fang 
Published: July 2019

The existence of toe debris at the bottom of the bored pile will reduce the bearing capacity of the pile. This paper develops a novel equipment to measure the thickness of toe debris for bored piles. The equipment consists of a test rod, test hammer, velocimeter, transmission cable and data receiving and processing device. Based on the one-dimensional wave theory, the mechanism of the sudden change of the velocity time curve received at the top of the test rod is analyzed, which is caused by the change of the wave impedance at the interface between the test rod and the sediment, thus the feasibility of the equipment is verified in theory. Finally, numerical simulations of toe debris under various working conditions are carried out to verify the reliability of the equipment. The results show that the test curves are sensitive to the materials of test rod using proposed equipment when the thickness of toe debris is equal or greater than 50 cm, and the test values are all larger than actual values, which meet the requirement of relevant specifications. The test results are more accuracy when the thickness of toe debris is less than 50 cm. when the excited force is large, not only the sudden change is easy to be discriminated, but also the test accuracy can be assured. The remainder toe debris meet the requirement of relevant specifications after clearing pile hole according the proposed method. And the device is not affected by the properties of the sediment material, which indicates that the proposed equipment can perform well to test the thickness of toe debris.
The inhibition of crystal growth of gypsum and barite scales in industrial water systems using green antiscalant
Authors: Abd-El-Khalek D. E. , Abd-El-Nabey B. A. , Abdel-kawi Mervat A. , Ebrahim Sh. , Ramadan S. R. 
Published: July 2019

AbstractMineral scale is a major flow assurance problem in industrial water systems. The antiscale properties of sunflower (Helianthus annuus) seed extract for CaSO4 and BaSO4 scales were investigated using NACE and conductivity tests, respectively. Comparative studies between the extract and 1-hydroxyethane-1,1-diphosphonic acid (HEDP), as commercial antiscalants, were done. The results revealed that the inhibition of CaSO4 scales using sunflower seed extract reached 100%, while HEDP achieved a maximum inhibition of 88%. Moreover, the maximum inhibition of BaSO4 scale in the presence of the extract was 84% compared with 86% in the presence of HEDP. Also microscopic examination showed that both inhibitors modified CaSO4 and BaSO4 crystals.
Bioactive Algal-Derived Polysaccharides: Multi-Functionalization, Therapeutic Potential and Biomedical Applications
Authors: Muhamad Ida Idayu , Zulkifli Nabilah , Selvakumaran Suguna a/p , Lazim Nurul Asmak Md 
Published: July 2019

Background:
In recent decades, there has been an increased interest in the utilization of polysaccharides
showing biological activity for various novel applications owing to their biocompatibility, biodegradability,
non-toxicity, and some specific therapeutic activities. Increasing studies have started in the past few years to
develop algal polysaccharides-based biomaterials for various applications.

Methods:
Saccharide mapping or enzymatic profiling plays a role in quality control of polysaccharides. Whereby,
in vitro and in vivo tests as well as toxicity level discriminating polysaccharides biological activities. Extraction
and purification methods are performed in obtaining algal derived polysaccharides followed by chromatographic
profiles of their active compounds, structural features, physicochemical properties, and reported biological activities.

Results:
Marine algae are capable of synthesizing Glycosaminoglycans (GAGs) and non-GAGs or GAG mimetics
such as sulfated glycans. The cell walls of algae are rich in sulfated polysaccharides, including alginate, carrageenan,
ulvan and fucoidan. These biopolymers are widely used algal-derived polysaccharides for biological
and biomedical applications due to their biocompatibility and availability. They constitute biochemical compounds
that have multi-functionalization, therapeutic potential and immunomodulatory abilities, making them
promising bioactive products and biomaterials with a wide range of biomedical applications.

Conclusion:
Algal-derived polysaccharides with clearly elucidated compositions/structures, identified cellular
activities, as well as desirable physical properties have shown the potential that may create new opportunities.
They could be maximally exploited to serve as therapeutic tools such as immunoregulatory agents or drug delivery
vehicles. Hence, novel strategies could be applied to tailor multi-functionalization of the polysaccharides from
algal species with vast biomedical application potentials.
The Role of Autophagy and Death Pathways in Dose-dependent Isoproterenolinduced Cardiotoxicity
Authors: Gyongyosi Alexandra , Zilinyi Rita , Czegledi Andras , Tosaki Agnes , Tosaki Arpad , Lekli Istvan 
Published: July 2019

Background:
Isoproterenol (ISO) is a non-selective β-adrenergic agonist. Our aims were to investigate
the autophagy and cell death pathways including apoptosis and necrosis in ISO-induced cardiac injury in a dosedependent
manner.

Methods:
Male Sprague-Dawley rats were treated for 24 hours with I. vehicle (saline); II. 0.005 mg/kg ISO; III.
0.05 mg/kg ISO; IV. 0.5 mg/kg ISO; V. 5 mg/kg ISO; VI. 50 mg/kg ISO, respectively. Hearts were isolated and
infarct size was measured. Serum levels of Troponin T (TrT), lactate dehydrogenase (LDH), creatine kinase isoenzyme
MB (CK-MB) were measured. TUNEL assay was carried out to monitor apoptotic cell death and Western
blot was performed to evaluate the level of autophagic and apoptotic markers.

Results:
Survival rate of animals was dose-dependently decreased by ISO. Serum markers and infarct size revealed
the development of cardiac toxicity. Level of Caspase-3, and results of TUNEL assay, demonstrated that
the level of apoptosis was dose-dependently increased. They reached the highest level in ISO 5 and it decreased
slightly in ISO 50 group. Focusing on autophagic proteins, we found that level of Beclin-1 was increased in a
dose-dependent manner, but significantly increased in ISO 50 treated group. Level of LC3B-II and p62 showed
the same manner, but the elevated level of p62 indicated that autophagy was impaired in both ISO 5 and ISO 50
groups.

Conclusion:
Taken together these results suggest that at smaller dose of ISO autophagy may cope with the toxic
effect of ISO; however, at higher dose apoptosis is initiated and at the highest dose substantial necrosis occurs.