bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identifying dynamics in strategic groups
Authors: Penagos-Londoño Gabriel Ignacio , Ruiz-Moreno Felipe 
Published: April 2019

PurposeThe purpose of this paper is to characterize the situation in the Spanish banking industry through the identification of strategic groups based on a set of variables.Design/methodology/approachTo do so, the authors use a 13-year data set and a time inhomogeneous hidden Markov model (HMM) in which the time variable transition matrix captures institutions’ group switching behavior to identify these strategic groups. In fact, the authors consider a mixture model is the data generation process.FindingsTwo groups are identified. These groups are primarily characterized by size and other strategic variables. The probability of remaining in a group is generally high: 87.28 per cent for SG1 and 61.84 per cent for SG2. The probability of switching groups is low: 12.72 per cent probability of switching from SG1 to SG2 and 38.16 per cent probability of switching from SG2 to SG1. Banks in SG1 seem more stable over time; they have low levels of switching behavior and well-defined long-term behavior. Banks in SG2 seem to evolve in terms of group membership.Originality/valueUsing an inhomogeneous HMM with time-variable transition matrix, this paper allows for time-varying parameters in the distributions to analyze the evolution of strategic group membership in this industry to detect changes in group strategy, changes in membership and the stability of groups over time.
Pattern‐guided dip estimation with plane‐wave destruction filters
Authors: Xue Zhiguang , Zhang Houzhu , Zhao Yang , Fomel Sergey 
Published: April 2019

ABSTRACTWe propose to use pattern‐guided dip estimation to mitigate aliasing problem that possibly exists in structure‐oriented data processing. A straightforward and effective approach of generating pattern‐guided dip is presented, which generally involves three rounds of standard dip estimation with plane‐wave destruction filters. The first use of plane‐wave destruction filter is for generating a mask operator distinguishing aliased and non‐aliased data, based on measuring the uncertainty of the first dip estimation. The second plane‐wave destruction filter uses the aliasing‐free portions of the input data, and the dip in the aliasing‐affected area is automatically padded with the ‘pattern’ dip by smoothing regularization. The result of the second plane‐wave destruction filter is used as the initial dip for the inversion of the last‐pass plane‐wave destruction filter, which produces a pattern‐guided dip. For some specific applications, the mask operator can be easily generated through other methods, and we can skip the first dip estimation. Two numerical examples, related to picking information using predictive painting and structure‐oriented interpolation, respectively, demonstrate that our pattern‐guided dip can effectively mitigate the aliasing problem in structure‐oriented data processing.
Gaming National Emergency Access Target performance using Emergency Treatment Performance definitions and emergency department short stay units
Authors: Hession Michael , Forero Roberto , Man Nicola W , Penza Luke , McDonald Wade 
Published: April 2019

AbstractObjectiveTo evaluate potential gaming of the 4 h ED length of stay metric known as the National Emergency Access Target (NEAT) in Australia and Emergency Treatment Performance (ETP) in New South Wales (NSW).MethodsDescriptive statistical analysis was used to recalculate and compare the scores for NEAT and the NSW ETP using variations in the definitions of their measurement on 32 184 presentations during 2016. A computer simulation using a discrete event model illustrated the effect of the use of ED short stay beds on the ETP scores.ResultsUsing the timestamp of the intent to discharge a patient, called, ‘ready for departure’ instead of the time of a patient physically leaving the department, resulted in an apparent 6% performance improvement. A local interpretation of the NSW state definition of the ‘transferred’ patient resulted in the ETP for ‘admitted’ patients improving by 16%. The discrete event model demonstrated that without changing patient length of stay, ETP scores can be improved by optimising the time of the admit decision or increasing the number of ED short stay beds.ConclusionsThe opportunity of NEAT may be squandered unless gaming of the definitions and use of ED short stay beds is addressed. We argue that the longstanding issue of ‘departure time’ should be defined as ‘physically leaving’ the department, in accordance with the Australasian College for Emergency Medicine (ACEM) definition. Patient occupancy is a real measure of ED resource use and NSW and national recommendations should be adjusted. ACEM accreditation of EDs should include review of their application of NEAT definitions to ensure they truly reflect patient flow processes.
Feasibility and surgical outcomes of video‐assisted thoracoscopic pulmonary resection in patients with advanced‐stage lung cancer after neoadjuvant chemoradiotherapy
Authors: Suh Jee Won , Park Seong Yong , Lee Chang Young , Lee Jin Gu , Kim Dae Joon , Paik Hyo Chae , Chung Kyoung Young 
Published: April 2019

Video‐assisted thoracoscopic surgery (VATS) is regarded as the standard treatment for lung cancer. However, the feasibility and safety of VATS for lung cancer after neoadjuvant chemoradiotherapy (CRT) is unclear. This study evaluated the feasibility and safety of VATS in patients who had received neoadjuvant CRT.MethodsBetween January 2008 and December 2017, 85 patients who were administered neoadjuvant CRT and underwent anatomic lung resection were enrolled. Fifty‐nine patients underwent open thoracotomy and 26 patients underwent VATS. The clinical characteristics and perioperative outcomes were reviewed.ResultsIn six of the initial 32 patients who underwent VATS, the procedure was converted to thoracotomy. Adjacent structural invasion (33.9% vs. 11.5%; P = 0.037) and combined resection (16.9% vs. 0%; P = 0.025) were higher in the open group than in the VATS group. Surgical duration was higher in the open group than in the VATS group (203.86 ± 65.97 vs. 173.27 ± 59.87 minutes; P = 0.046). With regard to postoperative outcomes, the length of the hospital stay was longer in the open group compared to the VATS group (14.46 ± 16.94 vs. 8.62 ± 4.72 days; P = 0.017). There was no significant difference in the three‐year disease‐free survival (69.3% vs. 67.9%; P = 0.879) or overall survival rates (76.6% vs. 61.9%; P = 0.516).ConclusionIn selected patients, VATS pulmonary resection after neoadjuvant CRT showed results comparable to that of thoracotomy in terms of postoperative outcomes, operative morbidities, and survival rate.
Whose Global, Which Health? Unsettling Collaboration with Careful Equivocation
Authors: Yates‐Doerr Emily 
Published: April 2019

ABSTRACTThe recent push for multidisciplinary collaboration confronts anthropologists with a long‐standing ethnographic problem. The terms we have to talk about what we do are very often the same as the terms used by those with whom we work, and yet we are often doing very different things with these terms. I draw on over a decade of “awkward collaboration” with scientists working in highland Guatemala to explore how challenges of equivocation play out in research focused on improving maternal/child nutrition. In the interactions I describe, epidemiologists undertake ethnography, anthropologists study scientists, and a Mam–Spanish translator works for projects organized around English‐language funding structures and aspirations. I detail situations in which methods, interests, and goals coalesce and diverge to argue for the importance ofcareful equivocation, a research technique attuned to unsettling binaries that does not result in sameness or unity. I offer suggestions for how this technique might productively reshape the emerging global health imperative to work together. [global health, controlled equivocation, co‐laboring, material‐semiotics, Guatemala]
Grandparents, kinship ties, and belonging after migration: the perspective of second‐generation grandchildren
Authors: SOURALOVÁ ADÉLA 
Published: April 2019

AbstractIn this article, I investigate the roles of grandparents for second‐generation immigrants who live with their parents in a different country from their grandparents. I draw on in‐depth interviews with second‐generation Vietnamese immigrants living in the Czech Republic, where they are very often raised by Czech caregivers. The carers and the children are joined through the process of caregiving and become grandmothers and grandchildren to each other. The analysis focuses on how the interviewees make sense of, interpret, and understand their roles as grandchildren vis‐à‐vis their Czech and Vietnamese grandmothers. It shows how, after migration, the kinship ties are performed, negotiated, and reproduced on a micro level of everyday life, with tasks of caring, homeland visits, and a transnational/face‐to‐face maintenance of intimacy. The article concludes that grandparents play an important role in the grandchildren's sense of belonging both to their family kin and to the homeland.
Research on reaction mechanism of colorimetric sensor array with lead and its application for determination of lead content of fish
Authors: Lv Riqin , Huang Xingyi , Aheto Joshua Harrington , Dai Chunxia , Tian Xiaoyu 
Published: April 2019

AbstractIn this article, quantum chemistry method was applied to study the reaction mechanism of colorimetric sensor array (CSA) and lead during lead content analysis of large yellow croaker. The molecular structure, bingding energy, and charge of pyridine azo compounds and porphyrin compounds before and after reaction with lead was selected as the evaluation index to investigate the ability of CSA sensor to bind with lead. The results showed that PA4 of pyridine azo compounds and P2 of porphyrin compounds were sensitive to lead. After theoretical analysis, a colorimetric sensor array was fabricated for lead detection in large yellow croaker with the selected pyridine azo compounds and porphyrin compounds. For comparison, the lead content in large yellow croaker was also detected by inductively coupled plasma mass spectrometry (ICP‐MS) method. A quantitative model based on support vector regression (SVR) for lead content in large yellow croaker was established. The correlation coefficient of 0.62374 for testing set was obtained. From the result obtained, there is the need to perform further research by selecting other sensitive chromogenic materials so as to achieve higher prediction accuracy.Practical ApplicationsLead exposure can cause physiological and neurological damage to humans. In this study, quantum chemistry method was applied to study the reaction mechanism of colorimetric sensor array and lead. Then a novel colorimetric sensor array was developed for the determination of lead in fish flesh. This method simplified the screening process of chromogenic sensitive materials. The method has potential to be applied to simplify the detection of lead in aquatic products by researchers and relevant detection departments.
Income Hedging, Dynamic Style Preferences, and Return Predictability
Authors: ADDOUM JAWAD M. , DELIKOURAS STEFANOS , KORNIOTIS GEORGE M. , KUMAR ALOK 
Published: April 2019

ABSTRACTWe propose a theoretical measure of income hedging demand and show that it affects asset prices. We focus on the value factor and first demonstrate that our demand estimates are correlated with the actual demands of retail and mutual fund investors. We then show that the aggregate high‐minus‐low (HML) demand predicts HML returns. Exploiting the state‐level variation in income risk, we demonstrate that state‐level hedging demands predict state‐level HML returns. A long‐short portfolio that exploits this hedging‐induced predictability earns an annualized risk‐adjusted return of 6%.
The Globalization Risk Premium
Authors: BARROT JEAN‐NOËL , LOUALICHE ERIK , SAUVAGNAT JULIEN 
Published: April 2019

ABSTRACTIn this paper, we investigate how globalization is reflected in asset prices. We use shipping costs to measure firms' exposure to globalization. Firms in low shipping cost industries carry a 7% risk premium, suggesting that their cash flows covary negatively with investors' marginal utility. We find that the premium emanates from the risk of displacement of least efficient firms triggered by import competition. These findings suggest that foreign productivity shocks are associated with times when consumption is dear for investors. We discuss conditions under which a standard model of trade with asset prices can rationalize this puzzle.
Comparison of diagnostic techniques for detection of Giardia duodenalis in dogs and cats
Authors: Saleh Meriam N. , Heptinstall Jack R. , Johnson Eileen M. , Ballweber Lora R. , Lindsay David S. , Werre Stephen , Herbein Joel F. , Zajac Anne M. 
Published: April 2019

AbstractBackgroundAn evaluation of currently available in‐clinic diagnostic tests for Giardia duodenalis infection of dogs and cats has not been performed. In addition, there is discordance among published diagnostic comparisons. The absence of a true gold standard for detecting Giardia duodenalis also complicates diagnostic evaluations.ObjectivesTo evaluate diagnostic tests commercially available in the United States for detecting Giardia duodenalis in dogs and cats, in comparison to a widely used reference test, the direct immunofluorescent assay (IFA), and also to compare the results of 2 methods of analysis: comparison of diagnostic tests to a reference test (IFA) and Bayesian analysis.AnimalsFecal samples from a convenience sample of 388 cats and dogs located in Colorado, Oklahoma, and Virginia.MethodsFecal samples were tested for Giardia duodenalis by zinc sulfate centrifugal fecal flotation and 4 different commercial diagnostic immunoassays. Results were analyzed via Bayesian analysis and by comparison to the IFA as the reference test.ResultsSensitivity and specificity by comparison to IFA was ≥82% and ≥90%, respectively, for all diagnostic tests in dogs and cats. When analyzed via Bayesian analysis, sensitivity and specificity were ≥83% and ≥95%, respectively. When ZnSO4 centrifugal fecal flotation results were combined with immunoassay results, there was no longer a significant difference between the sensitivities of the commercial in‐clinic immunoassays.Conclusion and Clinical RelevanceThe Bayesian analysis validates using IFA as the reference test. Differences in commercial in‐clinic immunoassay sensitivities can be mitigated when the results are combined with ZnSO4 centrifugal fecal flotation results.
Why Do States Adopt Truth Commissions After Transition?
Authors: Kim Hun Joon 
Published: April 2019

ObjectivesWhy do states create a truth commission after political transition? This article answers this question by testing three key theories after surveying the existing literature: transnational advocacy networks, the balance of power between old and new elites, and diffusion theory.MethodsCox proportional hazards models were used to explain the adoption of a truth commission. I used the Transitional Justice Database Project database on truth commissions in 71 countries that became democracies between 1980 and 2006.ResultStrong evidence supports transnational advocacy networks and diffusion explanations. First, active domestic and international advocacy is a key factor. Second, diffusion theory is supported, as establishing a truth commission in neighboring countries is a relevant factor. Transitional countries are most sensitive to truth commissions adopted in culturally similar countries.ConclusionI found empirical evidence supporting the relevance of diffusion, domestic advocacy groups, and international actors.
The Effect of Distraction Cards on Reducing Pain and Anxiety During Intramuscular Injection in Children
Authors: Canbulat Şahiner Nejla , Türkmen Ayşe Sonay 
Published: April 2019

AbstractAimThe aim of the present study was to evaluate the effectiveness of distraction cards in reducing pain and anxiety during intramuscular (IM) injection in children aged between 6 and 11 years.MethodsSixty children were randomized into two groups, the distraction group and controls. The children in the distraction group viewed distraction cards during the procedure. The children in the control group were allowed to have their family nearby when the routine injection procedure was performed, but no distraction techniques were employed. Children's Fear Scale was used to assess children's anxiety levels. Pain levels were assessed using the Wong‐Baker FACES pain rating scale via self‐reports, which were completed by the children and also by the parents and observer.ResultsThere were significant differences in the self‐, parent‐, and observer‐reported pain and parent‐ and observer‐reported anxiety levels between the distraction and control groups.Linking Evidence to ActionDistraction methods, such as distraction cards, should be used as a nursing intervention to reduce pain and anxiety during IM injection in children. This study contributes to the literature on nonpharmacologic pain relief methods during IM injection in children.
Mesozoic-Cenozoic evolution of the Eastern Kunlun Range, central Tibet, and implications for basin evolution during the Indo-Asian collision
Authors: Wu Chen , Zuza Andrew V. , Zhou Zhiguang , Yin An , McRivette Michael W. , Chen Xuanhua , Ding Lin , Geng Jianzhen 
Published: April 2019

Abstract
The present-day Tibetan plateau, which is the largest highland on Earth, formed primarily due to the India-Asia collision since 50–60 Ma. The development of the plateau has been associated with the Cenozoic development of two large intra-plateau sedimentary basins in north-central Tibet: the Qaidam and Hoh Xil basins to the north and south of the Eastern Kunlun Range, respectively. We conducted an integrated study of these two basins and the Eastern Kunlun Range that separates them to understand the timing and mechanisms of their development in order to decipher the growth and uplift history of the plateau. Crustal shortening in the Fenghuoshan-Nangqian and Qilian Shan-Nan Shan thrust belts initiated no later than the early Eocene, which formed the northern and southern boundaries of the combined Hoh Xil and Qaidam basins in central Tibet. The distinct two-stage development of the Hoh Xil basin suggests emergence of a topographic barrier between the Hoh Xil basin in the south and Qaidam basin in the north in the early Neogene, which is supported by the existing and new apatite fission-track data from the Eastern Kunlun Range that suggest rapid cooling after ca. 20 Ma. Previous and newly collected geochronological, petrological, and thermochronological data are best interpreted in the context of the Paleogene Paleo-Qaidam hypothesis, which requires Hoh Xil and Qaidam basins to have been parts of a single integrated basin during the early stage of the Cenozoic Tibetan plateau development.
Application of pulsed electric fields for the valorization of platelets with no therapeutic value for transfusion medicine
Authors: Rego Duarte , Redondo Luis , Casaleiro Sandro , Sousa Ana Paula , Abreu Sofia , Serra Margarida , Santo Vitor Espirito 
Published: April 2019

Platelets are blood components with high biomedical potential due to their physiological role in wound healing and their rich growth factor content. This paper describes proof-of-concept experiments aimed to produce a new blood-derived product by applying pulsed electric fields (PEF) to platelet concentrates (PC) with no therapeutic value for transfusion medicine. A human platelet concentrate suspension was subjected to a PEF treatment of 1 pulse, 5[Formula: see text]kV/cm, for 2[Formula: see text][Formula: see text]s. Release of platelet-derived growth factor (PDGF) from the electroporated platelets was measured by ELISA. Furthermore, the biological activity of the obtained blood-derived product was characterized. Human mesenchymal stem cells (hMSC) were cultured in the presence of the proteins released from the platelets after PEF application and evaluated for their expansion potential. Results show that platelet concentrates subjected to a single PEF treatment can release PDGF to the supernatant. Protein release from the single and transient PEF cycle was confirmed by the expansion of hMSC cultured with a medium supplemented with the platelet releasate obtained from electroporated platelets. These results demonstrate the potential of a new application of PEF for the valorization of PC into a biomedical product with therapeutic value.
MDM4 Is Targeted by 1q Gain and Drives Disease in Burkitt Lymphoma
Authors: Hüllein Jennifer , Słabicki Mikołaj , Rosolowski Maciej , Jethwa Alexander , Habringer Stefan , Tomska Katarzyna , Kurilov Roma , Lu Junyan , Scheinost Sebastian , Wagener Rabea , Huang Zhiqin , Lukas Marina , Yavorska Olena , Helfrich Hanne , Scholtysik René , Bonneau Kyle , Tedesco Donato , Küppers Ralf , Klapper Wolfram , Pott Christiane , Stilgenbauer Stephan , Burkhardt Birgit , Löffler Markus , Trümper Lorenz H. , Hummel Michael , Brors Benedikt , Zapatka Marc , Siebert Reiner , Kreuz Markus , Keller Ulrich , Huber Wolfgang , Zenz Thorsten 
Published: April 2019

Abstract

Oncogenic MYC activation promotes proliferation in Burkitt lymphoma, but also induces cell-cycle arrest and apoptosis mediated by p53, a tumor suppressor that is mutated in 40% of Burkitt lymphoma cases. To identify molecular dependencies in Burkitt lymphoma, we performed RNAi-based, loss-of-function screening in eight Burkitt lymphoma cell lines and integrated non-Burkitt lymphoma RNAi screens and genetic data. We identified 76 genes essential to Burkitt lymphoma, including genes associated with hematopoietic cell differentiation (FLI1, BCL11A) or B-cell development and activation (PAX5, CDKN1B, JAK2, CARD11) and found a number of context-specific dependencies including oncogene addiction in cell lines with TCF3/ID3 or MYD88 mutation. The strongest genotype–phenotype association was seen for TP53. MDM4, a negative regulator of TP53, was essential in TP53 wild-type (TP53wt) Burkitt lymphoma cell lines. MDM4 knockdown activated p53, induced cell-cycle arrest, and decreased tumor growth in a xenograft model in a p53-dependent manner. Small molecule inhibition of the MDM4–p53 interaction was effective only in TP53wt Burkitt lymphoma cell lines. Moreover, primary TP53wt Burkitt lymphoma samples frequently acquired gains of chromosome 1q, which includes the MDM4 locus, and showed elevated MDM4 mRNA levels. 1q gain was associated with TP53wt across 789 cancer cell lines and MDM4 was essential in the TP53wt-context in 216 cell lines representing 19 cancer entities from the Achilles Project. Our findings highlight the critical role of p53 as a tumor suppressor in Burkitt lymphoma and identify MDM4 as a functional target of 1q gain in a wide range of cancers that is therapeutically targetable.

Significance:
Targeting MDM4 to alleviate degradation of p53 can be exploited therapeutically across Burkitt lymphoma and other cancers with wild-type p53 harboring 1q gain, the most frequent copy number alteration in cancer.