bluuebunny/crossref_metadata_2025_split huggingface dataset:
SF2523: Dual PI3K/BRD4 Inhibitor Blocks Tumor Immunosuppression and Promotes Adaptive Immune Responses in Cancer
Authors: Joshi Shweta , Singh Alok R. , Liu Kevin X. , Pham Timothy V. , Zulcic Muamera , Skola Dylan , Chun Hyun Bae , Glass Christopher K. , Morales Guillermo A. , Garlich Joseph R. , Durden Donald L. 
Published: April 2019

Abstract
Macrophages (MΘs) are key immune infiltrates in solid tumors and serve as major drivers behind tumor growth, immune suppression, and inhibition of adaptive immune responses in the tumor microenvironment (TME). Bromodomain and extraterminal (BET) protein, BRD4, which binds to acetylated lysine on histone tails, has recently been reported to promote gene transcription of proinflammatory cytokines but has rarely been explored for its role in IL4-driven MΘ transcriptional programming and MΘ-mediated immunosuppression in the TME. Herein, we report that BET bromodomain inhibitor, JQ1, blocks association of BRD4 with promoters of arginase and other IL4-driven MΘ genes, which promote immunosuppression in TME. Pharmacologic inhibition of BRD4 using JQ1 and/or PI3K using dual PI3K/BRD4 inhibitor SF2523 (previously reported by our group as a potent inhibitor to block tumor growth and metastasis in various cancer models) suppresses tumor growth in syngeneic and spontaneous murine cancer models; reduces infiltration of myeloid-derived suppressor cells; blocks polarization of immunosuppressive MΘs; restores CD8+ T-cell activity; and stimulates antitumor immune responses. Finally, our results suggest that BRD4 regulates the immunosuppressive myeloid TME, and BET inhibitors and dual PI3K/BRD4 inhibitors are therapeutic strategies for cancers driven by the MΘ-dependent immunosuppressive TME.
IL1R8 Deficiency Drives Autoimmunity-Associated Lymphoma Development
Authors: Riva Federica , Ponzoni Maurilio , Supino Domenico , Bertilaccio Maria Teresa Sabrina , Polentarutti Nadia , Massara Matteo , Pasqualini Fabio , Carriero Roberta , Innocenzi Anna , Anselmo Achille , Veliz-Rodriguez Tania , Simonetti Giorgia , Anders Hans-Joachim , Caligaris-Cappio Federico , Mantovani Alberto , Muzio Marta , Garlanda Cecilia 
Published: April 2019

Abstract
Chronic inflammation, including that driven by autoimmunity, is associated with the development of B-cell lymphomas. IL1R8 is a regulatory receptor belonging to the IL1R family, which negatively regulates NF-κB activation following stimulation of IL1R or Toll-like receptor family members. IL1R8 deficiency is associated with the development of severe autoimmune lupus-like disease in lpr mice. We herein investigated whether concomitant exacerbated inflammation and autoimmunity caused by the deficiency of IL1R8 could recapitulate autoimmunity-associated lymphomagenesis. We thus monitored B-cell lymphoma development during the aging of IL1R8-deficient lpr mice, observing an increased lymphoid cell expansion that evolved to diffuse large B-cell lymphoma (DLBCL). Molecular and gene-expression analyses showed that the NF-κB pathway was constitutively activated in Il1r8−/−/lpr B splenocytes. In human DLBCL, IL1R8 had reduced expression compared with normal B cells, and higher IL1R8 expression was associated with a better outcome. Thus, IL1R8 silencing is associated with increased lymphoproliferation and transformation in the pathogenesis of B-cell lymphomas associated with autoimmunity.
Speech Intelligibility in Dysarthrias: Influence of Utterance Length
Authors: Barreto Simone dos Santos , Ortiz Karin Zazo 
Published: April 2019

<b><i>Aim:</i></b> To analyze the effect of utterance length on the intelligibility of words produced by dysarthric speakers. <b><i>Methods:</i></b> A total of 10 adult speakers with dysarthria (5 men and 5 women; mean age 58.8 years, SD 14.1) took part in the study. Six speakers exhibited mild-to-moderate impairment, while 4 had severe-to-extreme impairment, according to scores on the single-words subtest of the Protocol for the Evaluation of Speech Intelligibility in Dysarthrias (PESI). The speakers were recorded producing, by repetition, a list of 25 sentences from the sentence subtest of the PESI plus a list of 25 separate words taken from the same sentence list. The speech samples were sound recorded and subsequently transcribed by 40 listeners. Intelligibility scores were calculated according to the percentage of target words correctly transcribed in each list of stimuli. <b><i>Results:</i></b> The intelligibility scores for the target words produced in sentences were lower than the scores obtained by utterance of single words (<i>z</i> = –2.82; <i>p</i> &#x3c; 0.01). This difference was not consistently due to dysarthria severity. <b><i>Conclusion:</i></b> The results of the present study support the hypothesis that utterance length can negatively influence speech intelligibility in people with dysarthria.
Modeling and simulation of quasi-Z-source indirect matrix converter for permanent magnet synchronous motor drive
Authors: Nori Ahmed Muthenaa , Hassan Turki K. 
Published: April 2019

This paper aims to use a three-phase quasi-Z-source indirect matrix converter (QZSIMC) to expand the voltage gain for application in a Permanent Magnet Synchronous Motor (PMSM) drives. In this converter, a unique quasi-Z-source network (QZSN) connects the three-phase input voltage to conventional indirect matrix converter (IMC) in order to boost the supply voltage for PMSM because of limited voltage gain of IMC. Dual space vector modulation (SVM) is utilized to control the QZSIMC. The amplitude of output voltage for quasi-Z-source network is raised by the shoot-through of the rectifier stage, so the system voltage gain becomes greater. Through selecting the optimized value of shoot through duty ratio (<em>D</em>) and modulation index of the rectifier stage (), the drive system can automatically regulate the output voltage of QZSIMC during conditions of voltage sag , step change in load torque and reference speed change when the required voltage gain of QZSIMC is more than 0.866 depending on input voltage and required output voltage.The vector control technique based on closed loop speed control is proposed to control speed of the motor from zero to rated speed which is combined with the proposed converter to obtain the motor drive. The simulation results with MATLAB /Simulink 2015 are obtained to validate performance of PMSM drive.
Modos de contato na música cênica contemporânea
Authors: Bonin Gustavo 
Published: April 2019

Com base nas direções propostas pelo texto “As condições semióticas das mestiçagem” de Claude Zilberberg, o artigo irá circunscrever a Música Cênica Contemporânea como uma prática que coloca em jogo o contato entre elementos musicais e cênicos, ambos regidos por uma organização musical subjacente. Na guia das diversas vertentes da música contemporânea e experimental, alguns autores ressaltam a presença cênica dos concertos de música utilizando estratégias de iluminação, figurino, gestualidade, encenação etc. Propomos observar as estratégias de dominâncias, transportes e ambivalências entre as presenças musicais e as presenças cênicas, através da configuração gradativa e aspectual dos modos de contato. Zilberberg prevê quatro estados aspectuaise graduais de interação, que vai da mais próxima à mais afastada [fusão – mescla – contiguidade – separação], e também duas sintaxes elementares da mistura, a de participaçãoe a de privação, em que se representa, aspectualmente, a movimentação das grandezas que constituem as presençasem contato. Por fim, esboçaremos uma descrição da regência musical como uma base sensível que orienta a percepção do sujeito envolvido na prática híbrida de Música Cênica.
Contemporary Use of Embolic Protection Devices During Saphenous Vein Graft Intervention
Authors: Valle Javier A. , Glorioso Thomas J. , Schuetze Katherine B. , Grunwald Gary K. , Armstrong Ehrin J. , Waldo Stephen W. 
Published: April 2019

Background:
Guidelines recommend use of embolic protection devices during percutaneous coronary intervention of saphenous vein grafts, but the use of these devices in contemporary practice is unclear. We thus sought to evaluate the patient characteristics and clinical outcomes associated with embolic protection device use during contemporary saphenous vein graft percutaneous coronary intervention.

Methods and Results:

We identified patients undergoing isolated saphenous vein graft percutaneous coronary intervention in the Veterans Affairs Healthcare System from January 2008 to June 2017. Patient and procedural characteristics associated with embolic protection device use were assessed, as well as unmeasured site variation. A propensity-matched cohort was constructed to compare outcomes at 30 days, including unsuccessful intervention, periprocedural myocardial infarction, and death. We identified 7266 vein graft interventions, and embolic protection was used in 37.9% of cases, with a significant decline over time (
P
=0.001) that was most pronounced from 2014 to 2017 (
P
<0.001). There was significant institutional variation in the use of embolic protection, with a 15.50 (95% credible interval, 9.21–29.71)-fold difference in odds of device use by changing facilities independent of patient or procedural factors. Use of embolic protection was associated with reduced risk of unsuccessful intervention (odds ratio, 0.27; 95% credible interval, 0.17–0.42) and 30-day mortality (odds ratio, 0.56; 95% credible interval, 0.36–0.87).

Conclusions:
Use of embolic protection is decreasing with time and occurs in less than half of vein graft interventions. There is significant site variation in the use of embolic protection independent of patient characteristics, suggesting opportunities for the development of uniform practices to improve outcomes among those undergoing saphenous vein graft percutaneous coronary intervention.
Triglyceride and Triglyceride/HDL (High Density Lipoprotein) Ratio Predict Major Adverse Cardiovascular Outcomes in Women With Non‐Obstructive Coronary Artery Disease
Authors: Prasad Megha , Sara Jaskanwal Deep , Widmer Robert J. , Lennon Ryan , Lerman Lilach O. , Lerman Amir 
Published: April 2019

Background
Women with non‐obstructive coronary artery disease have increased cardiovascular morbidity. The role of risk factors in this population has yet to be established. We aimed to study the predictive effect of triglycerides and the triglyceride/high‐density lipoprotein ratio on major adverse cardiovascular events (MACE) in patients with non‐obstructive coronary artery disease, and to explore the role of lipid lowering therapy in modifying this risk.

Methods and Results

This is a prospective cohort study enrolling patients with anginal symptoms referred to the cardiac catheterization laboratory for suspected ischemia, who were subsequently diagnosed with non‐obstructive coronary artery disease, defined as no stenosis >20% on angiography. All patients had baseline laboratory testing and were followed for 7.8±4.3 years for the development of major adverse cardiovascular events. We performed Cox proportional hazard testing to determine the effect of triglycerides on risk of major adverse cardiovascular events among men and women by baseline statin use. A total of 462 patients were included. Median age was 53 (Q1, Q3: 45, 62) years. In a Cox proportional hazard model stratified by statin use adjusting for confounders, among those not on baseline statins, triglycerides were independently predictive of major adverse cardiovascular events in women (per 50 mg/dL risk ratio: hazard ratio 1.25 [95%
CI
: 1.06, 1.47];
P
=0.01). This was not true among men. The interaction between triglycerides and sex, and triglycerides and statin was statistically significant.

Conclusions
Triglyceride levels may play a key role in predicting cardiovascular‐specific risk in women, and statin use may be protective. Further investigation is necessary to better delineate the role of statin use in preventing cardiovascular risk.
Magnitude of the Difference Between Clinic and Ambulatory Blood Pressures and Risk of Adverse Outcomes in Patients With Chronic Kidney Disease
Authors: Ku Elaine , Hsu Raymond K. , Tuot Delphine S. , Bae Se Ri , Lipkowitz Michael S. , Smogorzewski Miroslaw J. , Grimes Barbara A. , Weir Matthew R. 
Published: April 2019

Background

Obtaining 24‐hour ambulatory blood pressure (
BP
) is recommended for the detection of masked or white‐coat hypertension. Our objective was to determine whether the magnitude of the difference between ambulatory and clinic
BP
s has prognostic implications.

Methods and Results

We included 610 participants of the AASK (African American Study of Kidney Disease and Hypertension) Cohort Study who had clinic and ambulatory BPs performed in close proximity in time. We used Cox models to determine the association between the absolute systolic
BP
(
SBP
) difference between clinic and awake ambulatory BPs (primary predictor) and death and end‐stage renal disease. Of 610
AASK
Cohort Study participants, 200 (32.8%) died during a median follow‐up of 9.9 years; 178 (29.2%) developed end‐stage renal disease. There was a U‐shaped association between the clinic and ambulatory
SBP
difference with risk of death, but not end‐stage renal disease. A 5– to <10–mm Hg higher clinic versus awake
SBP
(white‐coat effect) was associated with a trend toward higher (adjusted) mortality risk (adjusted hazard ratio, 1.84; 95%
CI,
0.94–3.56) compared with a 0– to <5–mm Hg clinic‐awake
SBP
difference (reference group). A ≥10–mm Hg clinic‐awake
SBP
difference was associated with even higher mortality risk (adjusted hazard ratio, 2.31; 95% CI, 1.27–4.22). A ≥−5–mm Hg clinic‐awake SBP difference was also associated with higher mortality (adjusted hazard ratio, 1.82; 95% CI, 1.05–3.15) compared with the reference group.

Conclusions

A U‐shaped association exists between the magnitude of the difference between clinic and ambulatory
SBP
and mortality. Higher clinic versus ambulatory BPs (as in white‐coat effect) may be associated with higher risk of death in black patients with chronic kidney disease.
The Role of Antioxidants in the Treatment of Congenital CMV‐Related Hearing: A Case‐Control Study
Authors: McCrary Hilary , del Calvo Veronica , Purser Jeremy , Casazza Geoff , Park Albert 
Published: April 2019

ObjectiveAntioxidants have been used as a therapeutic measure for several causes of hearing loss, and this study aims to examine the use of antioxidants in children with congenital cytomegalovirus (cCMV)–related hearing loss.Study DesignCase‐control study.SettingAcademic pediatric hospital.Subjects and MethodsA retrospective chart review of pediatric patients with cCMV‐related hearing loss treated with and without antioxidants (vitamins A, C, and E and magnesium, known as ACE‐Mg) was completed. The primary end point was the mean change in hearing thresholds for the right and left ears after therapy. An evaluation of the mean change in thresholds was evaluated at the following frequencies: 500 Hz, 1000 Hz, 2000 Hz, and 4000 Hz. A 2‐sample t test and multiple linear regression were used to evaluate the data.ResultsA total of 78 children with cCMV‐related hearing loss were included in the study, of whom 10 were treated with antioxidants. The average amount of time in which antioxidants were taken was 387 days. When comparing cases and controls, there was no differences in the mean change of hearing thresholds at each frequency for both the right and left ears (P >. 05). Length of antioxidant therapy and age at which therapy was initiated had no effect on hearing scores (P >. 05).ConclusionsOxidative stress plays a role in the pathogenesis of cCMV‐related hearing loss. ACE‐Mg is a safe adjuvant therapy for the treatment of hearing loss in children; however, this study demonstrates no hearing‐related benefit from ACE‐Mg antioxidant therapy.
<p><strong>Checklist of Indian Lebiinae Bonelli, 1810 (Coleoptera: Carabidae)</strong></p>
Authors: SHIJU RAJ T. , SABU THOMAS K. 
Published: April 2019

Distribution patterns and literature details of 263 Lebiinae species reported from India are provided. List includes 14 species missed out by Andrewes (1930a) and the 98 species described thereafter. Distribution patterns revealed among the 263 species, 104 species are exclusively Oriental species and 35 species are exclusively Palaearctic species. Among the 263 Indian speceis, 130 species are exclusively Indian species with reports only from the Indian subcontinent and one species with report only from Andaman & Nicobar Islands. Of the 130 Indian species, 89 species are recorded from the Oriental, 27 species from the Palaearctic and 14 species recorded from both Oriental and Palaearctic regions in India. Among the 129 Indian subcontinent species, 45 species are endemics to the three global hotspots of the biodiversity in India with 31 species endemic to the Western Ghats and Sri Lanka hotspot of biodiversity; six species endemic to the Eastern Himalayas hotspot of biodiversity; eight species endemic to the Indo-Burma hotspot of biodiversity; four species recorded only from Chota Nagpur plateu and 27 species recorded only from Indian Himalayas. Four species (Microlestes parvati, Singilis indicus, S. squalidus and Lebia cardoni) recorded only from Chota Nagpur plateu and the 31 endemic species from the Western Gahts and Sri Lanka are of special interest for their Gondwana relationships. 133 species have wider geographic distribution pattern with 15 species having distribution in Oriental and Indian regions; 8 species having distribution in Palaeractic and Indian regions; 10 species having distribution in Oriental and Indo-Australian regions; 48 species with distribution in Oriental and Palaearctic regions; 29 species with distribution in Oriental, Indo-Australian and Palaearctic regions; 2 species with distribution in Oriental, Australian and Palaearctic regions; 6 species with distribution in Oriental, Palaearctic and Afrotropical regions; 9 species with distribution in Oriental, Indo-Australian, Australian and Palaearctic regions; and 6 species with random distributions in different regions. Distribution records indicate that the arrival/origin of 228 species- 137 species with wider geographic distribution outside India and the 91 species with Indian distribution and not endemics to the Western Ghats and the Chotanagpur Plateau- is likely to have occurred after the joining of Indian subcontinent with Asian continent and during the subsequent faunal exchange between the newly formed Indian subcontinent and the surrounding regions (Indo-Burma and Indo-China on the north east front; Mediterranean and Ethiopian regions on the north-western front; Central Asian elements on the northern front). These 228 species represent the younger Indian Lebiinae species compared to the 35 species representing the older/ancient species with Gondwana land origin. Key words: Carabidae, Lebiinae, Perigonini, Pentagonicini, Odacanthini, Cyclosomini, Lebiini, India
Scale Characteristics and Effects on Spatial Variability of Soil Available Nutrients
Authors: Zhao Gengxing , Dong Chao , Chen Xiaona , Su Baowei 
Published: April 2019

Abstract.The spatial variability of farmland soil nutrients on different scales is important for farming as it forms the basis for the efficient utilization of soil nutrients and precision fertilization. Survey points were distributed throughout the study area on three different scales (county, field, and block). Research on the scale effect of the spatial variability of available nitrogen (AN), available phosphorus (AP), and available potassium (AK) involved a combination of classical statistics, geostatistics, and Geographic Information System (GIS) techniques. Results indicated that the three kinds of nutrients presented moderate variation intensity on the three scales. All of the nutrients tested exhibited strong spatial autocorrelation, indicating that spatial variability was primarily affected by structural factors, including climate, soil type and topography. As the sampling scale decreased, the nutrients showing weak variation at the large scale exhibited great variation at the small scale; the spatial autocorrelation of these three nutrients first became greater and then weakened; the distance of the spatial autocorrelation shortened gradually. Furthermore, the patch density value of the soil nutrient map increased, which indicated that the distribution of nutrients tended to be more fragile. When combined, sampling methods on the multi-scale allowed us to obtain real and systematic soil information. This study explored scale characteristics and the effects of spatial variability with regards to the primary nutrients available on farmland and provided a theoretical basis to effectively understand the nutrient status of regional farmland and improve the efficacy of soil sampling. Keywords: Multi-scale, Geostatistics, Patch density, Fractal dimension, Kriging interpolation.
MARINA COLASANTI E A VIOLÊNCIA CONTRA A MULHER NA OBRA CONTOS DE AMOR RASGADO
Authors: Bedin Coelho Simone Silvia , Cabreira Maria do Carmo , Oliveira Valdeci Batista de Melo 
Published: April 2019

ResumoO tema da violência contra as mulheres, seja de forma física, ou, conforme Pierre Bourdieu (2004), "simbólicaâ€, está presente em textos literários. Na análise de contos do livro "Contos de amor rasgados" (1986), da autora Marina Colasanti, é possível observar a representação dessa violência, pois a mulher é representada em alguns momentos apenas como pano de fundo, e em outros é enfraquecida, passiva, sujeitada ao desejos/favores de seu marido/amante, justificando parte da expressão "amor rasgadoâ€, expressão que metaforiza as relações de amor que não deram certo, e essa metáfora é confirmada na medida em que os contos têm personagens masculino e feminino em constante situação de confronto. A análise aqui apresentada parte dos estudos de Zilbermann a respeito da Estética da Recepção como metodologia de leitura e apreciação do texto literário e do Método Recepcional das autoras Bordini e Aguiar (1993). Palavras-chave: Contos. Mulher. Violência. Estética da Recepção. MARINA COLASANTI AND VIOLENCE AGAINST WOMEN IN THEÂ WORK TALES OF RIPEN LOVEAbstract The issue of violence against women, whether in physical form or, as Pierre Bourdieu (2004), "symbolic", is present in literary texts. In the book of short stories analysis, "ripped Love Stories" (1986) by Marina Colasanti, you can see the representation of violence. Sometimes women are represented as a backdrop, and in others it is weak, passive, subjected to the desires / favors from husband / lover, explaining part of the expression "torn love," by which a metaphor for the love relationships did not work, and this metaphor is confirmed in tales that male andÂ female characters are in constant confrontation. It is an analysis proposed on Zilbermann studies about the Aesthetics of Reception as reading methodology and appreciation of the literary text and Recepcional method of Bordini authors and Aguiar (1993).Keywords: Tales. Woman. Violence. Aesthetics of Reception.Â
A PERSONAGEM LOU COMO TRANSGRESSORA DAS NORMAS SOCIAIS IMPOSTAS À MULHER NO SÉCULO XIX EM HUMANA, DEMASIADO, HUMANA
Authors: Sousa Fabiana Dos Santos 
Published: April 2019

Resumo O artigo apresenta um estudo da obra Humana, demasiado, humana, de Luzilá Gonçalves Ferreira, com ênfase na análise das personagens femininas, em especial, Lou Salomé. Busca- se compreender como essas mulheres transgrediram os padrões da sociedade do século XIX, época em que as mulheres estavam excluídas do poder político e educacional pura e simplesmente. Palavras-chave: Mulheres. Transgressora. Lou Andreas Salomé. Luzilá Gonçalves Ferreira. THE CHARACTER OF LOU AS A TRANSGRESSOR OF SOCIAL STANDARDSÂ IMPOSED ON WOMEN IN THE 19TH CENTURY IN HUMAN, TOO, HUMANAbstract The article presents a study of Human, too, human, by Luzilá Gonçalves Ferreira, emphasizing an analysis of female characters, particularly Lou Salome. We seek to understand how these women transgress the standards of the nineteenth century society, when women used to be excluded from political power and educational pure and simply. Keywords: Women. Transgressive. Lou Andreas Salomé. Luzilá Gonçalves Ferreira.