bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bagan Kendali Robust Multivariat untuk Pengamatan Individual
Authors: Herdiani Erna Tri , Ilyas Nirwan 
Published: December 2018

Bagan kendali yang paling banyak digunakan dalam pengendalian proses secara multivariat adalah bagan kendali T2 Hotelling. Ada 2 jenis dari bagan kendali Hotelling yaitu bagan kendali Hotelling untuk pengamatan kelompok dan individual. Pada tulisan ini membahas bagan kendali Hotelling untuk pengamatan individual. Bagan kendali ini digunakan untuk memonitor vektor rata-rata dan matriks kovariansi sampel. Vektor rata-rata dan matriks kovariansi sampel sangat sensitif terhadap titik ekstrim (outliers). Oleh karena itu dibutuhkan estimator vektor rata-rata dan matriks kovariansi populasi yang kekar terhadap data outliers. Salah satu metode yang dapat digunakan untuk mendeteksi data yang mengandung outliers adalah Minimum Covariance Determinant (MCD). Dari hasil perhitungan diperoleh bahwa bagan kendali T2 Hotelling dengan algoritma Fast-MCD lebih sensitif mendeteksi data outliers daripada T2 Hotelling klasik.
Penerapan Sparse Principal Component Analysis dalam Menghasilkan Matriks Loading yang Sparse
Authors: Tinungki Georgina M. , Sunusi Nurtiti i 
Published: December 2018

Sparse Principal Component Analysis (Sparse PCA) merupakan salah satu pengembangan dari metode PCA. Sparse PCA memodifikasi variabel-variabel baru yang merupakan kombinasi linear dari variabel lama (variabel asli) yang dihasilkan oleh metode PCA. Pemodifikasian variabel baru ini dilakukan dengan dengan menghasilkan matriks loading yang sparse sehingga variabel lama yang tidak efektif (memiliki nilai loading sama dengan nol) dapat dikeluarkan dari model PCA. Pada penelitian ini, metode Sparse PCA diterapkan pada data Indikator Kemiskinan Penduduk Indonesia Tahun 2015 yang memuat 13 variabel dan 34 observasi dengan reduksi variabel menghasilkan 4 (empat) variabel baru yang telah mampu menjelaskan 80,1% dari total variansi data. Hasil penelitian menunjukkan, matriks loading yang dihasilkan menggunakan metode Sparse PCA menjadi sparse dengan terdapat 11 elemen (nilai loading) matriks bernilai nol sehingga model yang dihasilkan menjadi lebih sederhana dan mudah untuk diinterpretasikan.
Estimasi Komponen Variansi pada Rancangan Faktorial Acak Lengkap Menggunakan Metode Generalized Least Squares
Authors: Angriany A. Muthiah Nur , Tinungki Georgina Maria , Raupong Raupong 
Published: December 2018

Perancangan percobaan adalah suatu uji atau sederet uji baik itu menggunakan statistika deskripsi maupun statistika inferensi, yang bertujuan untuk mengubah peubah input menjadi suatu output yang merupakan respon dari percobaan tersebut. Dalam perancangan percobaan, variansi dari faktor A, variansi dari faktor B, variansi interaksi faktor AB, dan variansi galat disebut dengan komponen varian. Penelitian ini bertujuan untuk mengestimasi komponen variansi pada rancangan faktorial acak lengkap model tetap dan model campuran menggunakan metode Generalized Least Squares (GLS), dimana metode GLS adalah pengembangan dari metode Ordinary Least Square yang biasa digunakan untuk mengatasi asumsi homogenitas yang biasa dilanggar dalam perancangan percobaan. Metode tersebut diterapkan pada data rancangan faktorial acak lengkap yaitu pengaruh berat jenis pakan pellet dengan kombinasi perlakuan penambahan bahan perekat dan lama penyimpanan. Hasil menunjukkan bahwa tidak terdapat pengaruh penambahan bahan perekat terhadap berat jenis pakan pellet. Selain itu, terdapat keragaman faktor lama penyimpan dan terdapat keragaman interaksi antara faktor penambahan perekat dan lama penyimpanan terhadap berat jenis pakan pellet.
APLIKASI MODEL EPIDEMIK SEIAR-SEI PADA PENYEBARAN PENYAKIT MALARIA DENGAN INFEKSI ASIMTOMATIK DAN SUPER INFEKSI
Authors: Belwawin Stella Maryana 
Published: December 2018

Penelitian ini bertujuan menentukan titik keseimbangan dan menganalisis kestabilan dari model SEIAR_SEI pada penyakit malaria dengan pengaruh infeksi asimtomatik, super infeksi, dan siklus hidup nyamuk. Penelitian ini juga bertujuan mengukur tingkat sensitivitas penyebaran penyakit malaria terhadap parameter infeksi asimtomatik, laju pengobatan, serta laju kelahiran nyamuk.melalu besaran . Metode yang digunakan dalam penelitian ini adalah metode deduktif dengan langkah-langkah : menentukan titik keseimbangan bebas penyakit dan endemik dan menentukan bilangan reproduksi dasar ). Analisis sensitivitas bilangan reproduksi dasar dilakukan terhadap parameter infeksi asimtomatik, pengobatan, dan laju kelahiran nyamuk. Tititk keseimbangan endemik diperoleh dengan aturan descrates. Hasil yang diperoleh menunjukkan parameter , , dan berpengaruh terhadap bilangan reproduksi dasar (). Faktor pengobatan berpengaruh terhadap eliminasi penyakit malaria. Sedangkan faktor infeksi asimtomatik dan laju kelahiran nyamuk dewasa berpengaruh terhadap peningkatan infeksi penyakit malaria
DETEKSI OUTLIER DENGAN METODE SIMPANGAN MUTLAK PADA KASUS HUBUNGAN ANTARA MOTIVASI KERJA DENGAN PRESTASI KERJA KARYAWAN
Authors: Makkulau Makkulau 
Published: December 2018

Outlier (pencilan) adalah suatu data yang terpisah jauh dari kumpulan data lainnya. Penelitian ini bertujuan untuk mendeteksi outlier menggunakan metode simpangan mutlak untuk kasus data hubungan antara motivasi kerja karyawan dengan prestasi kerja karyawan. Untuk mendeteksi outlier digunakan plot pencar, nilai leverasi (hii), dan sisaan dibuang ter-student-kan. Data outlier ditinjau dari nilai-nilai X berdasarkan nilai leverasi terbesar yaitu h4 = 108, h19 = 193, dan h26 = 108. Ketiga nilai tersebut melebihi kriteria 2 kali rataan nilai leverasi, 2p/n = 0,08, sehingga nilai amatan ke-4, 19, dan 26 merupakan outlier. Sedangkan berdasarkan nilai mutlak sisaan dibuang ter-student-kan, diperoleh outlier adalah amatan ke-24 dan 41. Model regresi yang digunakan tanpa outlier adalah Y = 38,470 + 0,952X dengan nilai R2 = 0,838
The Impact of Housing and HIV Treatment on Health-Related Quality of Life Among People With HIV Experiencing Homelessness or Unstable Housing
Authors: Giordano Thomas P. , Gallagher Kerrin , Davich Jo Ann Whitlock , Rathore Mobeen , Borne Deborah , Davies Erika , Altice Frederick L. , Cabral Howard 
Published: December 2018

Objectives. To determine the impact of improvements in housing and HIV clinical parameters on health-related quality of life (HRQOL) in persons with HIV infection experiencing homelessness. Methods. This prospective cohort study took place in 9 US sites. Local efforts sought to improve HIV and housing status. Longitudinal data analyses determined the impact of changes in housing status, HIV suppression, and CD4 cell counts on HRQOL at 12 months, measured as mental and physical component summary scores. Results. Among 909 participants enrolled from 2013 to 2016, 75.1% were homeless, 51.6% did not have HIV suppression, and 23.6% had a CD4 count less than 200 cells per cubic millimeter. Median mental and physical component summary scores were 35.4 and 38.9, respectively. These 5 parameters all improved by 6 months. In multivariate modeling, maintaining or achieving stable housing predicted higher PCS at 12 months, but CD4 count and HIV suppression improvements did not. Improvements in housing, CD4 count, and HIV suppression did not predict mental component score at 12 months. Conclusions. Housing and HIV treatment are necessary but not sufficient to improve HRQOL in this challenging population. The high prevalence of socioeconomic and mental health needs we found support the call for patient-centered comprehensive care.
Longitudinal Determinants of Housing Stability Among People Living With HIV/AIDS Experiencing Homelessness
Authors: Marcus Ruthanne , de Groot Alexander , Bachman Sara , Chisolm Nicole , Quadri Yasmeen , Cabral Howard , Rajabiun Serena 
Published: December 2018

Objectives. To examine patterns of and factors associated with housing stability over time among people living with HIV (PLWH) experiencing homelessness with co-occurring substance use and mental health disorders enrolled in a patient-centered medical home (PCMH) intervention. Methods. Between September 2013 and February 2017, we ascertained housing trajectories among PLWH in 9 sites in the United States by conducting interviews at baseline, 6, and 12 months after and dichotomized them as improved consistently versus did not improve consistently. We identified covariates affecting housing stability using the socioecological model. Results. Forty-three percent (n = 198) experienced consistent housing improvement. Participants with history of mental health diagnosis (adjusted odds ratio [AOR] = 1.55; 95% confidence interval [CI] = 1.02, 2.35; P = .04) or trauma (AOR = 1.72; 95% CI = 1.22, 2.41; P = .006) had improved housing status; those with recent injecting drug use (AOR = 0.41; 95% CI = 0.19, 0.90; P = .03) had less consistent housing improvement. Conclusions. Improved housing stability may possibly reflect the importance of PCMH interventions that integrate housing, health, and behavioral services with patient navigators to address complex needs of PLWH experiencing homelessness.
Longitudinal Stigma Reduction in People Living with HIV Experiencing Homelessness or Unstable Housing Diagnosed With Mental Health or Substance Use Disorders: An Intervention Study
Authors: Maskay Manisha Harisingh , Cabral Howard J. , Davila Jessica A. , Whitlock Davich Jo Ann , Marcus Ruthanne , Quinn Emily K. , Rajabiun Serena 
Published: December 2018

Objectives. To assess changes in perceived external stigma among people living with HIV (PLWH) experiencing homelessness or unstable housing diagnosed with mental health or substance use disorders following an intervention including care coordination and navigation assistance, building trusting relationships, addressing unmet needs, and reducing barriers to seeking and engaging in care. Methods. This study was part of a national multisite intervention project delivered at 6 geographically diverse sites throughout the United States from September 2013 through February 2017. Participant surveys were conducted at baseline, 6 months, and 12 months. We assessed perceived external stigma, defined as people’s beliefs about others’ attitudes toward them, related to HIV, homelessness, mental health disorders, and substance use disorders with modified stigma scales. Results. A total of 548 individuals participated. At baseline, more participants reported experiencing any perceived external HIV stigma (81%) than any stigma related to homelessness and mental health or substance use disorders (38.9%). Over time, those reporting any HIV stigma decreased significantly from baseline (81%) to 61.4% and 57.8% at 6 and 12 months, respectively. Conclusions. PLWH experiencing homelessness or unstable housing with mental health or substance use disorders are impacted by multilayered stigma. Interventions to engage them in care may help reduce stigma.
Tills y otros depósitos relacionados con la dinámica glaciar en la Sierra do Xistral: Interpretación de litofacies y reconstrucción paleoglaciar
Authors: Valcárcel Díaz Marcos 
Published: December 2018

Los aparatos glaciares que se desarrollaron el a Sierra do Xistral originaron un modelado glaciar poco marcado pero evidente. Se ha descrito la presencia de crestas morrénicas, planas fluvioglaciares, bloques erráticos y kames. La presencia de afloramientos en los que se puedan estudiar depósitos de origen glaciar es relativamente escasa, pero esto no impide que se presenten buenos ejemplos. En el presente trabajo discuten tipos de tills, tanto subglaciares como supraglaciares así como depósitos fluvioglaciares y torrenciales. Su interpretación es un elemento importante a la hora de comprender la dinámica glaciar en este sector. El método de trabajo es el habitual es este tipo de estudio, que comprende una valoración de visu de los distintos afloramientos y su integración en el contexto geomorfológico local.
SOSYAL HİZMET ÖĞRENCİLERİNİN KPSS'YE HAZIRLIK SÜREÇLERİNİN SOSYAL HİZMET EĞİTİMİNE YANSIMALARI: NİTEL BİR ARAŞTIRMA
Authors: BAŞER Doğa 
Published: December 2018

Bu çalışmanın amacı Selçuk Üniversitesi Sağlık Bilimleri Fakültesi Sosyal Hizmet Bölümü 3. ve 4. sınıf Öğrencilerinin KPSS’ye hazırlık süreçlerinin sosyal hizmet eğitimi bağlamında ne anlam ifade ettiğinin belirlenmesidir. Çalışma nitel araştırma tasarımına uygun olarak şekillendirilmiş ve çalışmada fenomenolojik yaklaşımın “tanımlayıcı fenomenoloji” biçimi kullanılmıştır. Çalışma grubu olarak 2018 senesinde KPSS’ye girecek olan Selçuk Üniversitesi Sosyal hizmet bölümü 3. ve 4. sınıf öğrencileri dikkate alınmıştır. Veriler araştırmanın amacı doğrultusunda araştırmacı tarafından oluşturulan yapılandırılmış açık uçlu görüşme formu ile toplanmıştır. Verilerin değerlendirilmesinde içerik analizi tekniği kullanılmıştır. Sosyal hizmetöğrencileri KPSS’yi zorunluluk, garanti ve kısa yol olarak değerlendirmektedir. KPSS ile ilgili duygu boyutunda “umut”, “stres”, “korku” ve “hayal kırıklığı” temaları, düşünce boyutunda ise “zor”, “gereksiz” ve “ne yapacağız?” temaları vurgulanmıştır. KPSS’ye hazırlık sürecinin teorik derslerine etkisine yönelik öğrencilerin “sınav haftası”, “etkilemedi” “yoğunluk”, “vicdan azabı”, “derste test” ve “odaklanamama” temalarına odaklandıkları görülmektedir. KPSS’ye hazırlık sürecinin sosyal hizmet uygulaması sürecine etkisine yönelik ise “yoğunluk”, “öncestaj”, “odaklanamama”, “test çözme” temalarının vurgulandığı görülmektedir. Sonuç ve tartışma bölümünde KPSS dışı alternatif kariyer olanakları, sosyal hizmet uzmanı istihdam imkanlarının araştırılması, KPSS sürecinde olan sosyal hizmet öğrencilerine danışmanlık verilmesi ve psikolojik destek noktasında yönlendirilmesi, mesleki bilgiyi ölçecek soruların KPSS sınavına dahil edilmesi konularına değinilmiştir.
Establishing meter under registration on domestic premises with roof tanks
Authors: Pearson D. , Preston N. , Al-Naimi A. , Smith C. 
Published: December 2018

Abstract
The Public Authority for Electricity and Water in Oman carried out an initial estimate of legitimate domestic night consumption (LDNC) based on an assessment of night consumption surveys of over 1,500 premises. However, no allowance for meter under-registration (MUR) had been applied in the assessment. This paper reports on a study to identify MUR in Oman, which can be applied to the results of the survey for LDNC. All premises in Oman are required to have a roof tank in order for customers to maintain their supply in the case of mains water supply interruptions. Regulations require that the roof tanks provide at least two days' storage. It is believed that roof tanks could have a significant impact on MUR due to the long ‘tails’ generated by the operation of the ball valve controlling the refilling of the roof tank. It was therefore decided that a study should be carried out to review the main drivers for MUR and the likely level of MUR to be expected in Oman, particularly at low flows such as those experienced at night time when a single toilet is flushed. In regards to the sample of properties included in the MUR survey, it was suspected that in the case of apartment blocks, the revenue meters will normally be located after the roof tank, in which case the roof tank will not influence MUR. This study sought to confirm this. Half the premises were fitted with an unmeasured flow reducer on a bypass so that the potential of such devices to reduce MUR could be investigated. Oman has continuous water supply. There were no supply interruptions during the study. The paper describes details of the plumbing arrangements developed for the study and the results established as part of the programme. It also takes the opportunity to report on the level of daily and night consumption experienced on the study area.
Chemistry and Biology of Farnesol and its Derivatives: Quorum Sensing Molecules with Immense Therapeutic Potential
Authors: Gupta Payal , Sharma Meenakshi , Arora Neha , Pruthi Vikas , Poluri Krishna Mohan 
Published: December 2018

Background:
Farnesol is an acyclic sesquiterpene alcohol, endogenously synthesized via the
ergosterol pathway. It is a quorum sensing molecule (QSM) that was first discovered in C. albicans, and
is involved in the inhibition of hyphae formation.

Methods:
This review focuses on the comprehensive details of occurrence, chemical/biological synthesis
of farnesol and its derivatives, and the factors involved in the regulation of their production. Further,
the review also presents their cellular functions and diversified biomedical applications.

Results:
Large-scale production of farnesol can be achieved using chemical synthesis and metabolic engineering
approach. Farnesol is involved in the regulation of various physiological processes including
filamentation, biofilm development, drug efflux, and apoptosis, etc. Farnesol and its derivatives/ analogues
have also been reported to exhibit anti-biofilm, anti-cancer, anti-tumor and fungicidal properties.
The antimicrobial potential of farnesol has been enhanced by synergizing it with known antifungal
drugs, and also through nano-formulation(s).

Conclusion:
Apart from its quorum sensing activity, farnesol can be used as an effective anti-microbial,
anti-inflammatory, ant-allergic, anti-cancerous, and anti-obesity agent.
New Quinazoline-Sulfonylurea Conjugates: Design, Synthesis and Hypoglycemic Activity
Authors: Abou-Seri Sahar M. , Taha AlShaimaa M. , Mohamed Mona A. , Abdelkader Nour M. 
Published: December 2018

Background:Sulphonylureas are the oldest and commonly used to treat diabetic patients, but its efficacy declines by time. It was reported that quinazoline nucleus exhibits a potent hypoglycemic effect in diabetic animal models.Objective:The current study aimed to synthesize new quinazoline-sulfonylurea conjugates and evaluate their hypoglycemic effects in alloxan-induced diabetic rats.Methods:The conjugates were synthesized by bioisosteric replacement of 5-chloro-2-methoxybenzamide moiety in glibenclamide or 1,3-dioxo-3,4-dihydroisoquinoline moiety in gliquidone with 6,7-dimethoxy-4-oxoquinazoline moiety (compounds 4a-4d, 9b-9c and 10b-10d). Diabetes was induced in rats by a single i.p. administration of alloxan, followed by treatment with the synthesized conjugates (5mg/kg Body weight).Results:All conjugates showed hypoglycemic effects with different efficacy indicated by the reduction in blood glucose and elevation of insulin levels. Moreover, these conjugates up-regulated the expression of pancreatic glucose transporter 2, muscle glucose transporter 4, and insulin receptor substrate-1 genes, compared to the diabetic group. A normal pancreatic tissue pattern was noticed in diabetic rats treated with compounds 9b, 9c, and 10c.Conclusion:Conjugation of sulfonylurea with quinazoline (especially 9b, 9c, 10c) possessed a significant hypoglycemic effect through improving blood insulin level and insulin action and consequently increased the glucose uptake by the skeletal muscles.
Berberine Effects on NFκB, HIF1A and NFE2L2/AP-1 Pathways in HeLa Cells
Authors: Belanova Anna , Beseda Darya , Chmykhalo Victor , Stepanova Alisa , Belousova Mariya , Khrenkova Vera , Gavalas Nikolaos , Zolotukhin Peter 
Published: December 2018

Background:
Berberine has multitudinous anti-cancer stem cells effects making it a highly promising
candidate substance for the next-generation cancer therapy. However, berberine modes of action predispose it to
significant side-effects that probably limit its clinical testing and application.

Materials and Methods:
HeLa cells were treated with two concentrations of berberine (30 and 100 µM) for 24
hours to assess the functioning of the NFE2L2/AP-1, NFκB and HIF1A pathways using 22 RNAs expression
qPCR-based analysis.

Results:
Berberine effects appeared to be highly dose-dependent, with the lower concentration being capable of
suppressing the NFκB functioning and the higher concentration causing severe signaling side-effects seen in the
HIF1A pathway and the NFE2L2 sub-pathways, and especially and more importantly in the AP-1 sub-pathway.

Conclusion:
The results of the study suggest that berberine has clinically valuable anti-NFκB effects however
jeopardized by its side effects on the HIF1A and especially NFE2L2/AP-1 pathways, its therapeutic window
phenomenon and its cancer type-specificity. These, however, may be ameliorated using the cocktail approach,
provided there is enough data on signaling effects of berberine.
SAK ETAP, Kualitas Laporan Keuangan dan Jumlah Kredit yang diterima UMKM
Authors: Murti AA Krisna , Trisnadewi AA Ayu Erna , Citraresmi Luh Diah , Saputra Komang Adi Kurniawan 
Published: December 2018

Persiapan dan pemanfaatan laporan keuangan yang merupakan bagian dari aspek keuangan yang dapat membantu usaha kecil menengah (UKM) dalam mengembangkan bisnis. Informasi akuntansi yang terkandung dalam laporan keuangan dapat digunakan untuk pengambilan keputusan manajemen, mengurangi biaya agensi dan sebagai informasi untuk kreditur (Allee dan Yohn 2009; Cassar 2009). Pada bulan Mei 2009 Dewan Standar Akuntansi Keuangan telah mengeluarkan Standar Akuntansi Keuangan Entitas tanpa Akuntabilitas Publik (SAK ETAP), efektif pada tanggal 1 Januari 2011. Penelitian ini bertujuan untuk mengetahui hubungan antara kualitas laporan keuangan dan SAK ETAP terhadap jumlah kredit yang diterima oleh UKM. Penelitian ini merupakan penelitian kuantitatif, menggunakan data primer, pengumpulan data menggunakan kuesioner yang disebarkan kepada 100 responden online dan offline yang berlokasi di Jakarta, Jawa Barat dan Bali. Hasil penelitian ini menunjukkan bahwa kualitas laporan keuangan mempengaruhi jumlah kredit yang didapat oleh UMKM yang berarti bahwa semakin berkualitas laporan keuangan jumlah kredit yang dapat diperoleh lebih besar dari perusahaan yang tidak memiliki laporan keuangan yang kurang berkualitas. Penelitian ini membuktikan bahwa kualitas laporan keuangan SME menjadi pertimbangan pihak luar dalam mengambil keputusan, terbukti dengan pengaruh kualitas laporan keuangan pada jumlah kredit yang diterima oleh UKM. Informasi atau sosialisasi, latar belakang pendidikan memiliki pengaruh positif dan signifikan terhadap pemahaman pengusaha tentang SAK ETAP
Keteladanan Dosen Fakultas Ekonomi UNP Dalam Meningkatkan Mutu Kegiatan Belajar Mahasiswa
Authors: Susanti Dessi , Armiati Armiati , Rahmidani Rose 
Published: December 2018

The purpose of this study was to: 1) identify exemplary lecturer Faculty of Economics, Universitas Negeri Padang as educators in improving the quality of student learning activities, 2) Analyze the contribution of exemplary lecturer at the Faculty of Economics Universitas Negeri Padang on the quality of student learning activities. This study uses a correlational approach, method of data collection that proportional sampling method, determination of the size of the sample using the formula slovin. Samples of 100 students from Faculty of Economics, Universitas Negeri Padang. The results of this study are 1) exemplary lecturer at the Faculty of Economics Universitas Negeri Padang as educators in improving the quality of student learning activities are currently on the criteria very well with the average indicators 4.2 and TCR 84; 2) exemplary lecturer at the Faculty of Economics Universitas Negeri Padang contributing to / effect on the quality of student learning activities with sig 0.001.
Internacionalização e gestão integral na instituição superior: visão atual e implicações
Authors: Rodriguez Pulido Josefa 
Published: December 2018

Internacionalização e gestão integral são ideias que devem ser incorporadas nas metas das universidades. Europa, América e outros continentes têm implementado estratégias para o seu desenvolvimento durante décadas. Nesse sentido, na instituição superior, esse processo deve ser desenvolvido em todas e em cada uma das áreas de conhecimento, bem como nas disciplinas que compõem os cursos ministrados nas salas de aula da universidade. Para atingir os objetivos estabelecidos, requer-se uma excelente gestão por meio da governança. Neste artigo, forneceremos uma visão geral das implicações e modalidades de internacionalização, bem como algumas considerações sobre o significado da gestão integral e dos processos integrais que a instituição superior deve assumir.