bluuebunny/crossref_metadata_2025_split huggingface dataset:
Estudio de prescripción-indicación en pacientes con antimicrobianos de amplio espectro en medicina interna de un hospital de Ecuador
Authors: Romero Viamonte Katherine , Berrones Martínez María Belén 
Published: February 2019

Introducción: desde hace varios años existe preocupación por el incremento específico en el consumo de antimicrobianos por los problemas que estos generan; por tal motivo, se decidió diseñar un programa de atención farmacéutica en pacientes hospitalizados en servicios abiertos para evitar el desarrollo de problemas relacionados con medicamentos asociados con antimicrobianos. Materiales y métodos: se realizó un estudio retrospectivo de utilización de medicamentos, del tipo prescripción-indicación en una muestra de estudio de 25 pacientes que recibieron antimicrobianos de amplio espectro en el área de medicina interna del hospital José María Velasco Ibarra desde abril hasta julio del 2016. Resultados: el 76 % de los pacientes fueron mujeres. La patología más frecuente que requirió la utilización de antimicrobianos fue la infección de vías urinarias complicada (48 %): el 24 % de los pacientes recibió más de un antibiótico de amplio espectro y el más utilizado fue el imipenem/cilastatina (34.4 %), seguido de la piperacilina/tazobactam y el cefepime, ambas con un 28.1% y la vancomicina (9.4%). El 48% de las prescripciones fueron inadecuadas, se detectó la presencia de PRM en el 84 % de los pacientes. Conclusión: el diseño de un programa de atención farmacéutica en pacientes hospitalizados garantiza la identificación, prevención y/o solución de los problemas relacionados con medicamentos, su uso adecuado y la calidad de la atención.
Prevalence of Victimization and Perpetration of Sexual Aggression in Undergraduate Students: A Systematic Review 2008-2018
Authors: Hernández Romero Hebe , Rincón Paulina , Castro Alzate Elvis Siprian 
Published: February 2019

Introduction: Sexual aggression (SA) is a public health problem present throughout the life of people, for this reason it is necessary to know its magnitude and scope. The objective of this study was to conduct a systematic review of empirical studies that include information on the prevalence of sexual aggression in undergraduate students. Materials and Methods: Two authors independently searched for publications between 2008-2018 in the Scopus®, Web of Science®, Scielo®, Redalyc® and Eric® databases. As inclusion criteria, empirical studies that report the prevalence of victimization and/or perpetration of sexual aggression in students since their admission to the university were considered. The evaluation was carried out independently by two evaluators who determined the risk of bias. In total, 35 articles were selected that met the inclusion criteria. Used methodology, sample sizes, measurement instruments, prevalence of victimization-perpetration of sexual aggression and perpetrator-victim relationship are indicated. Results: Although there are differences between the studies analyzed, the results indicate that unwanted sexual contact is the most frequent type of sexual aggression in both victimization and perpetration; however, several studies did not perform this subdivision and showed only general data of some type of sexual aggression. Discussion: The findings of the estimation of prevalence of sexual aggression and its subtypes in undergraduates since they enter university life are discussed, as well as future considerations related to terminology unification that allows to estimate more precise figures of the types of sexual aggression.
Arreglos neocorporatistas en la política habitacional. Un análisis de los Macroproyectos de Interés Social Nacional en Colombia
Authors: Alfonso R. Óscar A. 
Published: February 2019

El Estado contemporáneo tiene varias facetas. La del neocorporatismo es una forma moderna de representación de intereses que, en el caso de la política habitacional en Colombia, tomó cuerpo en un arreglo para producir suelo edificable con proyectos habitacionales para hogares pobres que enfrentó el impasse de la autonomía local en el ordenamiento territorial. La manera como se resolvió tal inconveniente es analizada con el empleo de una periodización ad hoc que pone de manifiesto que el arreglo neocorporatista de los Macroproyectos de Interés Social Nacional se produjo para enfrentar la crisis recesiva del sector constructor ocurrida en la coyuntura de 2008.
Política de vivienda y gestión de suelo urbano. Casos de Corea, Colombia y Perú (1990-2015)
Authors: Calderón Julio 
Published: February 2019

Bajo un análisis comparativo de los casos de Colombia, Perú y Corea del Sur, se relaciona el rol del Estado con el mercado y se resalta la importancia de la gestión del suelo urbano y los programas de vivienda. Basado en la revisión de la bibliografía, se concluye que, aunque esos países han atravesado por procesos de liberalización y privatización desde la década de 1990, difieren en su esquema institucional de atención a la vivienda y gestión del suelo: un Estado desarrollador y planificador que promueve asociaciones público/privadas (Corea), otro que combina mecanismos de subsidio con gestión del suelo (Colombia) y otro en el que impera el libre mercado (Perú).
Arthroscopic treatment of total knee arthroplasty complications
Authors: Encinas-Ullán Carlos A. , Rodríguez-Merchán E. Carlos 
Published: February 2019

The most frequent indications for arthroscopy in patients with total knee arthroplasty (TKA) are soft-tissue impingement, arthrofibrosis (knee stiffness), periprosthetic infection and removal of free bodies or cement fragments. When performing a knee arthroscopy in a patient with a symptomatic TKA, look for possible free/retained bone or cement fragments, which can be anywhere in the joint. Patellar tracking should be evaluated and soft-tissue impingement under the patella or between the femoral and tibial prosthetic components should be ruled out. Current data suggest that knee arthroscopy is an effective procedure for the treatment of some patients with symptomatic TKA. The approximate rates of therapeutic success vary according to the problem in question: 85% in soft-tissue impingement; 90% in arthrofibrosis; and 55% in periprosthetic infections. More clinical studies are needed to determine which patients with symptomatic TKA can be the best candidates for knee arthroscopy. Cite this article: EFORT Open Rev 2019;4:33-43. DOI: 10.1302/2058-5241.4.180035.
PENGUATAN JARINGAN PERPUSTAKAAN (NETWORKLIBRARY) SEBAGAI UNSUR POTENSIAL DALAM MENINGKATKAN AKSES LAYANAN PERPUSTAKAAN BAGI MAHASISWA UNIVERSITAS
Authors: Samsiyah Siti 
Published: February 2019

Universitas Terbuka (UT) sebagai perguruan tinggi jarak jauh (PTJJ) memiliki karakteristik khusus dalam sistem pembelajarannya.Mahasiswa dan dosen tidak bertemu secara intensif tatap muka setiap hari. Dalam sistem pembelajarannya mahasiswa dibantu melalui berbagai media yang berisi materi perkuliahan. Ragam media ini sebagai sarana pembelajaran meliputi, program computer assisted instruction (CAI), dry lib, audio-video, program tv channel sky-lbs, tv feature, radio feature. Sebagai perguruan tinggi berkonsep PTJJ, terdapat karakteristik yang berbeda juga dalam layanan perpustakaannya. Kalau perguruan tinggi konvensional mahasiswa dapat secara langsung berkunjung ke gedung perpustakaan memilih, meminjam koleksi perpustakaan, selain itu juga mahasiswa dapat mengakses semua koleksi atupun memesan koleksi melalui internet. Sedangkan UT sebagai PTJJ, mahasiswa memiliki keterbatasan dalam mengakses koleksi perpustakaan secara off line/kunjungan langsung secara fisik ke perpustakaan. Karena mahasiswa yang tersebar di seluruh tanah air, praktis koleksi perpustakaan yang bisa dinikmati secara kunjungan langsung oleh mahasiswa yang berada di lokasi Jakarta, Bogor, Depok Tangerang dan Bekasi (Jabodetabek.). Penelitian deskriptif dengan pendekatan kualitatif ini bertujuan untuk mengidentifikasi penguatan jaringan perpustakaan sebagai upaya meningkatkan akses layanan perpustakaan bagi mahasiswa UT sebagai layanan perpustakaan bagi mahasiswa PTJJ. Dengan sumber data dari mahasiswa UT, pustakawan, dan sumber data sekunder berupa dokumentasi akses koleksi perpustakaan dan data statistik menunjukkan bahwa penguatan jaringan perpustakaan UT sangat diperlukan bagi mahasiswa. Diantaranya penguatan jaringan perpustakaan FKP2TN (Forum Kerjasama Perpustakaan Perguruan Tinggi Negeri), Aspika (Asosiasi penyelenggara Pendidikan Tinggi Ilmu Perpustakaan dan Informasi Indonesia ). Hal ini untuk mengatasi keterbatasan akses secara off line mahasiswa pada perpustakaan UT sekaligus meningkatkan kualitas pembelajaran.
Menyelamatkan Arsip dari Bencana : Antara Idealisme dan Realitas
Authors: Suliyati Titiek 
Published: February 2019

Artikel ini bertujuan memberikan masukan pada lembaga kearsipan, baik di tingkat pusat maupun daerah serta lembaga swasta dalam upaya menyelamatkan arsip dari bencana alam maupun bencana akibat ulah manusia. Metode yang digunakan dalam penulisan artikel ini adalah analisa diskriptif yaitu melakukan analisa literatur-literatur, dokumen, perundang-undangan dan peraturan tentang kearsipan dan penyelamatan arsip vital dari bencana, serta sejumlah sumber sekunder lainnya. Dari analisa tersebut memperlihatkan penanganan dan penyelamatan arsip dari bencana belum maksimal. Permasalahan dalam artikel ini adalah bagaimana kesesuaian antara penanganan dan penyelamatan arsip vital di daerah bencana dengan aturan dan perundang-undangan yang telah dibuat oleh pemerintah. Hasil pembahasan menunjukkan, bahwa walaupun telah ada aturan dan undang-undang tentang penyelamatan arsip, tetapi setiap terjadi bencana alam atau bencana lain yang disebabkan oleh manusia, penanganan dan penyelamatan arsip belum maksimal, sehingga jumlah arsip yang rusak dan musnah sangat tinggi. Hal ini sangat merugikan negara karena arsip vital tidak tergantikan.
Manajemen Layanan Repository Perguruan Tinggi
Authors: Suwanto Sri Ati 
Published: February 2019

Repository dapat mendukung diseminasi hasil penelitian baik siswa maupun dosen dan dapat meningkatkan pangkat perguruan tinggi. Untuk dapat menampilkan repository yang baik, dibutuhkan manajemen repositori yang baik. Ada banyak model management repositori yang perlu dikaji. Oleh karena itu penelitian ini mengkaji bagaimana pengelolaan suatu layanan Intitutional Repository (IR) khususnya repositori digital. Tujuannya adalah untuk mengetahui bagaimana manajemen layanan repositori perguruan tinggi dengan menggunakan desain penelitian kualitatif dan jenis penelitian literature review. Metode peneltian yang digunakan adalah studi literatur. Hasilnya menunjukkan bahwa ada berbagai model manajemen untuk repositori institusi (IR), antara lain ditinjau dari sisi layanan yang isinya yaiut: 1) Kerangka kerja layanan; 2) Deposit yang dimediasi; 3) Komunikasi masa. Di samping itu untuk meningkatkan layanan repository perlu diimplementasikan komponen-komponen evaluasi dari pemeringkatan Webometrics, yaitu Size, Visibility, Rich files, Scholar, dan Altmetrics.Ada beberapa hal yang perlu dipersiapkan dalam pengembangan manajemen repositori perguruan tinggi.
Inovasi Kegiatan Taman Bacaan Masyarakat (TBM)
Authors: Pramudyo Gani Nur , Ilmawan M. Roddy , Azizah Baiq , Anisah Meryta , Deo Yanuar 
Published: February 2019

Artikel ini bertujuan untuk menganalisis, mendeskripsikan dan mengetahui kegiatan inovatif yang dilakukan di TBM. Pengumpulan data dilakukan dengan cara observasi, wawancara, dokumentasi dan pengumpulan materi audiovisual. Peneliti terlibat langsung dalam penelitian dalam bentuk pengabdian masyarakat. Dalam penelitian ini, menjukkan terdapat kegiatan inovatif yang dilakukan TBM seperti bimbingan belajar,diskusi bareng, sholawatan, fotografi, pentas seni, sablon kaos, storybox, mewarnai, ngopi, nonton bareng, senam serta kegiatan lomba agustusan. Penelitian ini ditunjukkan kepada para pembaca yang aktif dalam meningkatkan minat baca serta pengelola TBM agar dapat mengembangkan kegiatan inovatif yang dimiliki.
Attitudes of Young European Consumers Toward Recycling Campaigns of Textile Companies
Authors: Grębosz-Krawczyk Magdalena , Siuda Dagna 
Published: February 2019

Abstract
The aim of this article was to identify the attitudes of young consumers in Europe toward recycling campaigns of clothing companies. In the article, the results of own empirical research conducted among young consumers from Poland, France, and Spain in the fourth quarter of 2017 are presented. Recycling campaigns implemented by fashion brands, consisting of exchanging old cloths for discount vouchers, are an example of environmentally friendly innovations and fit into the concept of circular economy. The research results confirmed a minor engagement of young consumers in recycling campaigns of clothing companies. However, they declared the willingness to participate in such actions. According to the authors, an effective marketing communication strategy is fundamental to engage young consumers in clothing recycling and develop sustainable forms of clothing disposal. Clothing companies that are perceived as supporting the environment have a chance to reinforce the brand image.
Refolding and in vitro characterization of human papillomavirus 16 minor capsid protein L2
Authors: Breiner Bastian , Preuss Laura , Roos Nora , Conrady Marcel , Lilie Hauke , Iftner Thomas , Simon Claudia 
Published: February 2019

Abstract
The minor capsid protein L2 of papillomaviruses exhibits multiple functions during viral entry including membrane interaction. Information on the protein is scarce, because of its high tendency of aggregation. We determined suitable conditions to produce a functional human papillomavirus (HPV) 16 L2 protein and thereby provide the opportunity for extensive in vitro analysis with respect to structural and biochemical information on L2 proteins and mechanistic details in viral entry. We produced the L2 protein of high-risk HPV 16 in Escherichia coli as inclusion bodies and purified the protein under denaturing conditions. A successive buffer screen resulted in suitable conditions for the biophysical characterization of 16L2. Analytical ultracentrifugation of the refolded protein showed a homogenous monomeric species. Furthermore, refolded 16L2 shows secondary structure elements. The N-terminal region including the proposed transmembrane region of 16L2 shows alpha-helical characteristics. However, overall 16L2 appears largely unstructured. Refolded 16L2 is capable of binding to DNA indicating that the putative DNA-binding regions are accessible in refolded 16L2. Further the refolded protein interacts with liposomal membranes presumably via the proposed transmembrane region at neutral pH without structural changes. This indicates that 16L2 can initially interact with membranes via pre-existing structural features.
Consequences in a softwood kraft pulp mill of initial high alkali concentration in the impregnation stage
Authors: Brännvall Elisabet , Kulander Ida 
Published: February 2019

Abstract
Impregnation with high initial concentration is fast and efficient, leading to a homogeneous delignification in the subsequent cook, resulting in improved screened pulp yield. To obtain high initial alkali concentration, the white liquor flow needs to be significantly increased. The moisture content of the wood chips and the alkali concentration of the white liquor limit the initial alkali concentration of the impregnation liquor that can be reached. It is therefore of interest to evaluate the possibility to implement high alkali impregnation (HAI) industrially and the consequences this would have on the mill system. The effect of HAI on mass and energy balances in a kraft pulp mill has been studied using mill model simulations. The sensitivity to disturbances in important parameters for process control has been compared to impregnation scenarios used industrially. It was shown that high initial alkali concentration can be achieved on industrial scale by increased white liquor flow. HAI has a positive effect on recovery flows and reduces the need for make-up chemicals. The HAI concept is less sensitive to variations in process parameters, such as chip moisture and white liquor concentration, thus diminishing the risk of alkali depletion in chip cores.
Macroscopic Virtual Particles Exist
Authors: Nimtz Günter 
Published: February 2019

Abstract
Virtual particles are expected to occur in microscopic processes, as they are introduced, for instance, by Feynman in quantum electrodynamics as photons performing in an unknown way in the interaction between two electrons. This note describes macroscopic virtual particles as they appear in classical evanescent modes and in quantum mechanical tunnelling particles. Remarkably, these large virtual particles are present in wave mechanics of elastic, electromagnetic, and Schrödinger fields.
Post-Encoding Amygdala-Visuosensory Coupling Is Associated with Negative Memory Bias in Healthy Young Adults
Authors: Kark Sarah M. , Kensinger Elizabeth A. 
Published: February 2019

The amygdala is well documented as the critical nexus of emotionally enhanced memory, yet its role in the creation of negative memory biases, better memory for negative compared with positive stimuli, has not been clarified. Although prior work suggests valence-specific effects at the moment of “online” encoding and retrieval, with enhanced visuosensory processes supporting negative memories in particular, here we tested the novel hypothesis that the amygdala engages with distant cortical regions after encoding in a manner that predicts inter-individual differences in negative memory biases in humans. Twenty-nine young adults (males and females) were scanned while they incidentally encoded negative, neutral, and positive scenes, each preceded by a line-drawing sketch of the scene. Twenty-four hours later, participants were scanned during an Old/New recognition memory task with only the line-drawings presented as retrieval cues. We replicated and extended our prior work, showing that enhanced online visuosensory recapitulation supports negative memory. Critically, resting-state scans flanked the encoding task, allowing us to show for the first time that individual differences in “off-line” increases in amygdala resting-state functional connectivity (RSFC) immediately following encoding relate to negative and positive memory bias at test. Specifically, post-encoding increases in amygdala RSFC with visuosensory and frontal regions were associated with the degree of negative and positive memory bias, respectively. These findings provide new evidence that valence-specific negative memory biases can be linked to the way that sensory processes are integrated into amygdala-centered emotional memory networks.SIGNIFICANCE STATEMENTDecades of research has placed the amygdala at the center of the emotional memory network. Despite the clinical importance of disproportionate memory for negative compared with positive events, it is not known whether post-encoding increases in amygdala-cortical coupling, possibly reflective of early consolidation processes, bear any influence on the degree or direction of such emotional memory biases. We demonstrate that, across participants, increases in post-encoding amygdala coupling with visuosensory and frontal regions are associated with more pronounced negative and positive memory biases, respectively. These findings provide the first evidence linking post-encoding amygdala modulation to the degree of negative or positive memory bias, emphasizing the need for valence-based accounts of the amygdala's role in emotional memory.
The impact of surgery in metastatic pancreatic neuroendocrine tumors: a competing risk analysis
Authors: He Chao-bin , Zhang Yu , Cai Zhi-yuan , Lin Xiao-jun 
Published: February 2019

Aim The role of surgery in the treatment of metastatic pancreatic neuroendocrine tumors (PNETs) was controversial. The objectives of this study were to illustrate the impact of surgery in improving the prognosis of patients with metastatic PNETs and build nomograms to predict overall survival (OS) and cancer-specific survival (CSS) based on a large population-based cohort.

Methods Patients diagnosed with metastatic PNETs between 2004 and 2015 from the Surveillance, Epidemiology, and End Results (SEER) database were retrospectively collected. Nomograms for estimating OS and CSS were established based on Cox regression model and Fine and Grey’s model. The precision of the nomograms was evaluated and compared using concordance index (C-index) and the area under receiver operating characteristic (ROC) curve (AUC).

Results The study cohort included 1966 patients with metastatic PNETs. It was shown that the surgery provided survival benefit for all groups of patients with metastatic PNETs. In the whole study cohort, 1-, 2- and 3-year OS and CSS were 51.5, 37.1 and 29.4% and 53.0, 38.9 and 31.1%, respectively. The established nomograms were well calibrated, and had good discriminative ability, with C-indexes of 0.773 for OS prediction and 0.774 for CSS prediction.

Conclusions Patients with metastatic PNETs could benefit from surgery when the surgery tolerance was acceptable. The established nomograms could stratify patients who were categorized as tumor-node-metastasis (TNM) IV stage into groups with diverse prognoses, showing better discrimination and calibration of the established nomograms, compared with 8th TNM stage system in predicting OS and CSS for patients with metastatic PNETs.
Short-Homology-Mediated CRISPR/Cas9-Based Method for Genome Editing in Fission Yeast
Authors: Hayashi Aki , Tanaka Katsunori 
Published: February 2019

Abstract
The CRISPR/Cas9 system enables the editing of genomes of numerous organisms through the induction of the double-strand breaks (DSB) at specific chromosomal targets. We improved the CRISPR/Cas9 system to ease the direct introduction of a point mutation or a tagging sequence into the chromosome by combining it with the noncanonical homology-directed DNA repair (HDR) based genome editing in fission yeast. We constructed convenient cloning vectors, which possessed a guide RNA (gRNA) expression module, or the humanized Streptococcus pyogenes Cas9 gene that is expressed under the control of an inducible promoter to avoid the needless expression, or both a gRNA and Cas9 gene. Using this system, we attempted the short-homology-mediated genome editing and found that the HDR pathway provides high-frequency genome editing at target loci without the need of a long donor DNA. Using short oligonucleotides, we successfully introduced point mutations into two target genes at high frequency. We also precisely integrated the sequences for epitope and GFP tagging using donor DNA possessing short homology into the target loci, which enabled us to obtain cells expressing N-terminally tagged fusion proteins. This system could expedite genome editing in fission yeast, and could be applicable to other organisms.
Zeigen junge Erwachsene Financial Literacy im ökonomischen Alltag? Eine realitätsnahe Alternative zu einfachen Wissensabfragen
Authors: Oehler Andreas , Horn Matthias , Wendt Stefan 
Published: February 2019

Zusammenfassung
Die häufig verwendeten Wissensabfragen zur Messung der Financial Literacy sind nur ein schwacher Prädiktor für tatsächliches Finanzverhalten. Dieser Beitrag verwendet daher Fallbeispiele als eine realitätsnahe Alternative zu Wissensabfragen, um auf die praktische Financial Literacy bzw. Financial Capability von jungen Erwachsenen zu schließen. Die Auswertungen zeigen, dass die Probanden eine gute bis sehr gute Financial Capability besitzen, und geben Anlass, bei weiteren Studien zur Financial Literacy praxistaugliche Fallbeispiele anstatt eher theoriebezogene Wissensabfragen einzusetzen