bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Chemogenetic Approach for the Optical Monitoring of Voltage in Neurons
Authors: Sundukova Mayya , Prifti Efthymia , Bucci Annalisa , Kirillova Kseniia , Serrao Joana , Reymond Luc , Umebayashi Miwa , Hovius Ruud , Riezman Howard , Johnsson Kai , Heppenstall Paul A. 
Published: December 2018

AbstractOptical monitoring of neuronal voltage using fluorescent indicators is a powerful approach for the interrogation of the cellular and molecular logic of the nervous system. Herein, a semisynthetic tethered voltage indicator (STeVI1) based upon nile red is described that displays voltage sensitivity when genetically targeted to neuronal membranes. This environmentally sensitive probe allows for wash‐free imaging and faithfully detects supra‐ and sub‐threshold activity in neurons.
A Versatile Halide Ester Enabling Li‐Anode Stability and a High Rate Capability in Lithium–Oxygen Batteries
Authors: Wang Di , Zhang Fan , He Ping , Zhou Haoshen 
Published: December 2018

AbstractLi‐O2 batteries are promising candidates for next‐generation high‐energy‐density battery systems. However, the main problems of Li–O2 batteries include the poor rate capability of the cathode and the instability of the Li anode. Herein, an ester‐based liquid additive, 2,2,2‐trichloroethyl chloroformate, was introduced into the conventional electrolyte of a Li–O2 battery. Versatile effects of this additive on the oxygen cathode and the Li metal anode became evident. The Li–O2 battery showed an outstanding rate capability of 2005 mAh g−1 with a remarkably decreased charge potential at a large current density of 1000 mA g−1. The positive effect of the halide ester on the rate capacity is associated with the improved solubility of Li2O2 in the electrolyte and the increased diffusion rate of O2. Furthermore, the ester promotes the formation of a solid–electrolyte interphase layer on the surface of the Li metal, which restrains the loss and volume change of the Li electrode during stripping and plating, thereby achieving a cycling stability over 900 h and a Li capacity utilization of up to 10 mAh cm−2.
Metal–Organic‐Framework‐Derived Hollow N‐Doped Porous Carbon with Ultrahigh Concentrations of Single Zn Atoms for Efficient Carbon Dioxide Conversion
Authors: Yang Qihao , Yang Chun‐Chuen , Lin Chia‐Her , Jiang Hai‐Long 
Published: December 2018

AbstractThe development of efficient and low energy‐consumption catalysts for CO2 conversion is desired, yet remains a great challenge. Herein, a class of novel hollow porous carbons (HPC), featuring well dispersed dopants of nitrogen and single Zn atoms, have been fabricated, based on the templated growth of a hollow metal–organic framework precursor, followed by pyrolysis. The optimized HPC‐800 achieves efficient catalytic CO2 cycloaddition with epoxides, under light irradiation, at ambient temperature, by taking advantage of an ultrahigh loading of (11.3 wt %) single‐atom Zn and uniform N active sites, high‐efficiency photothermal conversion as well as the hierarchical pores in the carbon shell. As far as we know, this is the first report on the integration of the photothermal effect of carbon‐based materials with single metal atoms for catalytic CO2 fixation.
Eisenporphyrin‐katalysierte C‐H‐Funktionalisierung von Indol mit Diazoacetonitril für die Synthese von Tryptaminen
Authors: Hock Katharina J. , Knorrscheidt Anja , Hommelsheim Renè , Ho Junming , Weissenborn Martin J. , Koenigs Rene M. 
Published: December 2018

AbstractDie Funktionalisierung von C‐H‐Bindungen mit Nichtedelmetallkatalysatoren ist ein wichtiges Forschungsgebiet für die Entwicklung effizienter und nachhaltiger Synthesemethoden. In diesem Artikel beschreiben wir die Entwicklung Eisenporphyrin‐katalysierter Reaktionen von Diazoacetonitril mit N‐Heterocyclen um so einen Zugang zu wertvollen Vorläufern zu Tryptaminen zu erhalten. Darüberhinaus berichten wir über experimentelle mechanistische Studien sowie über konzeptionelle Studien zu einer enzymatischen Synthese mit dem Enzym YfeX. Mit dem leicht zugänglichen FeTPPCl‐Katalysator konnten wir hoch effiziente C‐H‐Funktionalisierungsreaktionen von Indol und Indazol‐Heterocyclen zeigen. Diese Reaktionen können unter milden Reaktionsbedingungen, mit exzellenten Ausbeuten und großer Toleranz funktioneller Gruppen inklusive Anwendungen im Grammmaßstab durchgeführt werden und eröffnen so einen einzigartigen, effizienten Zugang zu Tryptaminen.
Furo[3,2‐b]pyridine: A Privileged Scaffold for Highly Selective Kinase Inhibitors and Effective Modulators of the Hedgehog Pathway
Authors: Němec Václav , Hylsová Michaela , Maier Lukáš , Flegel Jana , Sievers Sonja , Ziegler Slava , Schröder Martin , Berger Benedict‐Tilman , Chaikuad Apirat , Valčíková Barbora , Uldrijan Stjepan , Drápela Stanislav , Souček Karel , Waldmann Herbert , Knapp Stefan , Paruch Kamil 
Published: December 2018

AbstractReported is the identification of the furo[3,2‐b]pyridine core as a novel scaffold for potent and highly selective inhibitors of cdc‐like kinases (CLKs) and efficient modulators of the Hedgehog signaling pathway. Initially, a diverse target compound set was prepared by synthetic sequences based on chemoselective metal‐mediated couplings, including assembly of the furo[3,2‐b]pyridine scaffold by copper‐mediated oxidative cyclization. Optimization of the subseries containing 3,5‐disubstituted furo[3,2‐b]pyridines afforded potent, cell‐active, and highly selective inhibitors of CLKs. Profiling of the kinase‐inactive subset of 3,5,7‐trisubstituted furo[3,2‐b]pyridines revealed sub‐micromolar modulators of the Hedgehog pathway.
Umpolung Reactivity of Ynamides: An Unconventional [1,3]‐Sulfonyl and [1,5]‐Sulfinyl Migration Cascade
Authors: Prabagar B. , Mallick Rajendra K. , Prasad Rangu , Gandon Vincent , Sahoo Akhila K. 
Published: December 2018

AbstractA regioselective sulfonyl/sulfinyl migration cycloisomerization cascade of alkyne‐tethered ynamides is developed in the presence of XPhosgold catalyst. This reaction is the first example of a general [1,3]‐sulfonyl migration from the nitrogen center to the β‐carbon atom of ynamides, followed by umpolung 5‐endo‐dig cyclization of the ynamide α‐carbon atom to the gold‐activated alkyne, and final deaurative [1,5]‐sulfinylation. This process allows the synthesis of peripherally decorated unconventional 4‐sulfinylated pyrroles with broad scope from N‐propargyl‐tethered ynamides. In contrast, N‐homopropargyl‐tethered ynamides undergo intramolecular tetradehydro Diels–Alder reaction to provide 2,3‐dihydro‐benzo[f]indole derivatives. Control experiments and density‐functional theory studies were used to study the reaction pathways.
Acoustic damping flexible polyurethane foams: Effect of isocyanate index and water content on the soundproofing
Authors: Baghban Sahar Abdollahi , Khorasani Manouchehr , Sadeghi Gity Mir Mohamad 
Published: December 2018

ABSTRACTHigh‐efficiency sound absorbing flexible polyurethane foams (FPUFs) are manufactured using nonpolar polyester resin, methylene diphenyl diisocyanate, and other reagents by one‐shot bulk polymerization. In this study, the impact of the isocyanate index (90, 100, and 110) and water content (2.5 and 5%) on the microphase separation and soundproofing behavior of FPUFs are examined using atomic force microscopy, Fourier transform infrared spectroscopy, optical microscope, and an impedance tube device. The results reveal that the increase of the isocyanate index and water content leads to the increase of the cell size, cell size distribution, open‐cell content, cell wall roughness, and microphase separation. Also, maximum sound absorption coefficient (α) reaches to 0.98 and the average of α in the frequency range of 1500–4000 Hz increases from 0.7 to 0.87 by increasing the water content from 2.5 to 5% and isocyanate index from 90 to 110; therefore, acoustic damping performance enhances up to 26.24% due to the synergic effects of microphase separation on the viscose media formation, open‐cell content, cell wall roughness, cell size, and cell size distribution. In conclusion, FPUFs with an optimal amount of microphase separation and drainage flow can be a promising candidate for sound insulating materials. © 2018 Wiley Periodicals, Inc. J. Appl. Polym. Sci.2019,136, 47363.
Comb‐shaped diblock copolystyrene for anion exchange membranes
Authors: Zhu Meng , Zhang Xiaojuan , Su Yanxia , Wang Yiguang , Wu Yibo , Yang Dan , Wang Hao , Zhang Min , Zhang Min , Chen Quan , Li Nanwen 
Published: December 2018

ABSTRACTTo improve the properties of diblock copolystyrene‐based anion exchange membranes (AEMs), a series of AEMs with comb‐shaped quaternary ammonium (QA) architecture (QA‐PSm‐b‐PDVPPAn‐xC where x denotes the number of carbon atoms in different alkyl tail chains and has values of 1, 4, 8, and 10 and C denotes carbon) were designed and synthesized via subsequent quaternization reactions with three different alkyl halogens (methyl iodide and N‐alkane bromines (CH3[CH2]
x‐1Br where x = 4, 8, and 10). Compared with triblock analogues quaternized with methyl iodide in our previous research, QA‐PSm‐b‐PDVPPAn‐xC (x = 4, 8, and 10) AEMs are more flexible with the introduction of a long alkyl tail chain; this probably impedes crystallization of the rigid polystyrene‐based main chain and induces sterically adjustable ionic association. An increase in the pendant alkyl tail chain length generally led to enhanced microphase separation of the obtained AEMs, and this was confirmed using small‐angle X‐ray scattering and atomic force microscopy. The highest conductivity (25.5 mS cm−1) was observed for QA‐PS120‐b‐PDVPPA80‐10C (IEC = 1.94 meq g–1) at 20 °C. Furthermore, the water uptake (<30%) and swelling ratio (<13.1%) of QA‐PSm‐b‐PDVPPAn‐xC AEMs are less than half of these corresponding values for their triblock counterparts. The QA‐PS120‐b‐PDVPPA80‐10C membrane retained a maximum stability that was as high as 86.8% of its initial conductivity after a 40‐day test (10 M NaOH, 80 °C), and this was probably because of the steric shielding of the cationic domains that were surrounded by the longest alkyl tail chains. © 2018 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 47370.
Both farnesyl diphosphate synthase genes are involved in the production of alarm pheromone in the green peach aphid Myzus persicae
Authors: Cheng Yin‐Jie , Li Zheng‐Xi 
Published: December 2018

AbstractFarnesyl diphosphate synthase (FPPS) catalyzes the formation of FPP, providing the precursor for the biosynthesis of (E)‐β‐farnesene (EβF) in plants, but it is unknown if FPPS supplies the precursor for the biosynthesis of EβF, the major component of aphid alarm pheromone, though our previous studies support the hypothesis that EβF is synthesized by the aphid itself. Here, we used two cohorts of the green peach aphid
Myzus persicae separately, reared on pepper plant and artificial diet to test the correlations among droplet emission, EβF quantity, and FPPS gene expression. It was found that the proportion of aphids emitting cornicle droplets and the quantity of EβF per milligram of aphid were both significantly different between the two cohorts, which were positively correlated with the expression of the two FPPS genes (
MpFPPS1/
2) in
M. persicae. These results were further confirmed by RNAi‐mediated knockdown of
MpFPPS1/
2. Specifically, knockdown of
MpFPPS1/
2 imposed no significant cost on the survival of aphid but remarkably increased the number of offspring per aphid; most importantly, knockdown of
MpFPPS1/
2 significantly reduced the proportion of aphids emitting droplets and the quantity of EβF calculated as per the weight of aphid. Our results suggest that both FPPS genes are involved in the production of EβF in
M. persicae and cornicle droplet emission is closely associated with the EβF release in the aphid.
Good and bad market research: A critical review of Net Promoter Score
Authors: Fisher Nicholas I. , Kordupleski Raymond E. 
Published: December 2018

AbstractNet Promoter Score, touted as the “single customer metric you need” and calculated from customers' answer to one simple question about their loyalty, has been in use since 2003 and adopted in a wide variety of settings. However, it has not lived up to its claimed benefits. This article evaluates the NPS approach in terms of its positive and negative results.This article is for people interested in NPS, still considering implementing NPS in their company, or interested in its technical underpinnings. It points out the benefits and shortcomings and explains why, and it describes what can be done to achieve the outcomes NPS theory claimed it would produce, but has not.The article is written in two parts for quite distinct audiences: firstly, for executives and managers who need customer data and information to make marketing decisions; and secondly, for market researchers, statisticians, and business analysts who are responsible for capturing and providing reliable, understandable, and meaningful customer data to the executives and managers who need the information. Consequently, the two sections are written in two different styles. The first section takes the form of a summary for managers and executives of our findings and recommendations in language aimed at business leaders; the second section provides a detailed analysis and critical review of NPS for market researchers, statisticians, and business analysts. Both sections present a better solution than NPS for understanding what customers value, delivering the best value to customers, winning market share, and creating truly loyal customers.
Economic analysis of forest residues supply chain options to produce enhanced‐quality feedstocks
Authors: Sahoo Kamalakanta , Bilek Edward , Bergman Richard , Kizha Anil R. , Mani Sudhagar 
Published: December 2018

AbstractWoody biomass feedstock that is both high quality and low cost has become increasingly important for the bioenergy and bioproducts industries. Logging generates forest residues – low‐quality feedstock – and additional operations that also incur additional costs, such as biomass sorting and treetops processing (BSTP), micro‐chipping, and screening, which are required to improve the feedstock's quality. Considering recent developments in technologies and BSTP to generate high‐quality feedstocks, economic models were developed in this study to estimate various forest‐residue logistics operational costs and to analyze the economics of delivering feedstocks to biomass conversion technology (BCT) sites near woods or power plants located far away in the form of chips, hog fuel, and bales. The results show that the cost of BSTP can vary between $30 and $82/ODMT (oven dry metric ton) based on the biomass sorting intensity. The most economical way to deliver forest residues was transporting processed stem‐wood from landings to near‐wood BCT sites and comminuting it into woodchips there (~$20/ODMT, assuming a one‐way (32 km) road distance and no cost of BSTP at landings). Grinding slash at the landing and transporting ground‐biomass (i.e., hog fuel) to a plant (< 22 km away) was more economical than transporting bales from landings and grinding at the plant. The economic feasibility of baling and BSTP requires a substantial productivity improvement or recognition and incorporation of benefits including reduced wildfire risk and improved forest health. High bulk density and strong shape of forest residues/slash bales compared to hog fuel may provide additional cost benefits during storage, for example through lower handling costs, which can be studied in the future. © 2018 Society of Chemical Industry and John Wiley & Sons, Ltd
Konzepte für die Bewertung von Brücken mit Spannungsrisskorrosionsgefahr
Authors: Schacht Gregor , Käding Max , Bolle Guido , Marx Steffen 
Published: December 2018

AbstractDie Anzahl von Brücken im Netz der Straßenbauverwaltungen und der DB AG, die mit spannungsrisskorrosionsgefährdetem Spannstahl hergestellt wurden, ist nach wie vor hoch. Zwar existieren Vorschriften, die eine rechnerische und materialtechnische Beurteilung weitestgehend regeln, jedoch führen diese nicht immer zweifelsfrei zu einem (gewünschten) eindeutigen Ergebnis und der endgültigen Festlegung geeigneter Maßnahmen. Die messtechnische Dauerüberwachung spielt in diesem Zusammenhang bisher eine untergeordnete Rolle, obwohl die im Bauwerk ablaufenden Degradationsprozesse und deren Folgen bei Anwendung geeigneter Messverfahren sehr gut aufgelöst werden können und durch den kontinuierlichen Informationsgewinn jederzeit Aussagen zum Bauwerkszustand möglich sind. Der vorliegende Beitrag gibt zunächst einen Überblick über die existierenden Vorschriften und zeigt die Möglichkeiten und Grenzen der darin empfohlenen Methoden auf. Anschließend wird je ein Beispiel für die Umsetzung einer Überwachungsaufgabe an einem Bauwerk mit und ohne rechnerischem Ankündigungsverhalten vorgestellt.
Is learning outcome after team based learning influenced by gender and academic standing?
Authors: Das Saswati , Nandi Kajal , Baruah Priyanki , Sarkar Sajib K. , Goswami Binita , Koner Bidhan C. 
Published: December 2018

AbstractTeam based learning (TBL) is a time tested teaching–learning (T–L) tool involving collaborative learning but has hardly been tested for teaching clinical biochemistry to undergraduate medical students. The present study was designed to (a) compare problem solving skills of first year MBBS students after attending a TBL session on ‘organ function test’ with that of the students taught the same topic by didactic lecture, (b) assess their perception towards TBL and (c) evaluate if difference in academic standing and gender influence the learning outcome of TBL.One Hundred first professional MBBS students were divided by stratified randomization into two groups. Group I was exposed to TBL to teach ‘organ function tests’, while group II was taught the same topic by traditional lecture. The outcome of the T–L sessions was assessed by a test for problem solving skills. Student perception towards TBL was assessed from students' response to a questionnaire. No significant difference between the two groups in problem solving skills could be discerned. High achievers performed better after TBL session, while the low achievers were more benefited by traditional lecture method. The female students showed better academic performance after TBL in comparison to male students. The students gave positive feedback for TBL as an instructional technique. We conclude that TBL gives satisfaction, is not inferior to lecture in effectiveness and hence should be used as a T–L method for undergraduate medical students. Moreover, being more effective for female students and high achievers, it is judicious to utilize TBL more frequently for them in an attempt to provide the best individualized teaching. © 2018 International Union of Biochemistry and Molecular Biology, 47(1):58–66, 2018.
Use ofKluyveromyces marxianusprefermented wheat bran as a source of enzyme mixture to improve dough performance and bread biochemical properties
Authors: Zhang Binle , Wendan Yang , Wang Feng , Omedi Jacob Ojobi , Liu Ruoshi , Huang Jinxin , Zhang Luan , Zou Qibo , Huang Weining , Li Shaolei 
Published: December 2018

AbstractBackground and objectivesIn this study,Kluyveromyces marxianuswith ability to produce β‐glucosidase was used to preferment wheat bran (WB) and release a mixture of natural enzymes for improving dough performance and bread quality. Five different enzyme activities were analyzed. The effect of the prefermented WB with enzyme mixture on stickiness and microstructure of dough, ferulic acid release in bread, and molecular weight distribution of arabinoxylan were evaluated using Texture Analyzer, scanning electron microscopy (SEM), HPLC, and high‐performance gel filtration chromatography (HPGFC).FindingsKluyveromyces marxianusexhibited abundant extracellular β‐glucosidase activity (up to 6.98 U/g). The main enzymes released in prefermented bran were endoglucanase and exoglucanase, β‐glucosidase, xylanase, and ferulate esterases. These enzymes were active during bread making (only prefermented bran added as improver or combined with xylanase) and affected solubility and molecular weight distribution of dietary fiber, which resulted in positive improvement of dough performance, release of phenolic acid, and overall quality of the breads. The changes observed were attributed to the extracellular enzymes fromK. marxianusand endogenous enzymes activated during prefermentation, thus enhancing the WB functionality in bread.ConclusionsWheat bran bioprocessing using high enzyme producing yeasts increases functional application of wheat bran in baked products.Significance and noveltyThis study added new knowledge for developing a natural enzyme‐based improver for bran‐enriched baked products in the food industry.
Synthesis of the seco‐Limonoid BCD Ring System Identifies a Hsp90 Chaperon Machinery (p23) Inhibitor
Authors: Pinkerton David M. , Chow Sharon , Eisa Nada H. , Kainth Kashish , Vanden Berg Timothy J. , Burns Jed M. , Guddat Luke W. , Savage G. Paul , Chadli Ahmed , Williams Craig M. 
Published: December 2018

AbstractD‐Ring‐seco‐limonoids (tetranortriterpenoids), such as gedunin and xylogranin B display anti‐cancer activity, acting via inhibition of Hsp90 and/or associated chaperon machinery (e.g., p23). Despite this, these natural products have received relatively little attention, both in terms of an enabling synthetic approach (which would allow access to derivatives), and as a consequence their structure–activity relationship (SAR). Disclosed herein is a generally applicable synthetic route to the BCD ring system of the seco‐D‐ring double bond containing limonoids. Furthermore, cell based assays revealed the first skeletal fragment that exhibited inhibition of the p23 enzyme at a level which was equipotent to that of gedunin, despite being much less structurally complex.
Unique hue judgments using saturated and desaturated Munsell samples under different light sources
Authors: Huang Hsin‐Pou , Wei Minchen , Xiao Kaida , Ou Li‐Chen 
Published: December 2018

AbstractPast studies investigating the unique hues only used samples with a relatively high saturation levels under standard illuminants. In this study, 10 observers selected the four samples with unique hues from 40 V6C8 (Value 6 Chroma 8) and 40 V8C4 (Value 8 Chroma 4) Munsell samples under six light sources, comprising three levels of Duv (i.e., 0, −0.02, and −0.04) and two levels of correlated color temperature (i.e., 2700 and 3500 K). Significant differences were found between the two chroma levels for unique blue and yellow, with the hue angles of unique yellow and blue judged using the desaturated samples being significantly different from those defined in CIECAM02. The iso‐lines of unique yellow, blue, and green did not always go through the origin of the a*‐b* or a′‐b′ planes in CIELAB and CAM02‐UCS. Thus, the problems of CIECAM02, CIELAB, and CAM02‐UCS identified in this study need further investigations.