bluuebunny/crossref_metadata_2025_split huggingface dataset:
Continuous Kidney Replacement Therapy in Children With Sinusoidal Obstruction Syndrome After Hematopoietic Cell Transplant: Outcome and Liberation
Authors: Heyn Madeleine , Ashcraft Emily , Cheng Cheng , Epperly Rebecca , Elbahlawan Lama 
Published: December 2024

ABSTRACTBackgroundSinusoidal obstruction syndrome (SOS), a serious complication after hematopoietic cell transplant (HCT), is associated with multiorgan dysfunction (MOD) and a high mortality rate. In severe cases, continuous kidney replacement therapy (CKRT) is initiated to manage fluid overload (FO) and acute kidney injury. Studies that evaluate the use of CKRT in this population are lacking. The aim of our study was to assess the outcome of critically ill children with severe SOS post HCT who received CKRT. We also sought to assess factors associated with survival and liberation post CKRT.ProcedureRetrospective review of all children admitted to the intensive care unit (ICU) with SOS post HCT who received CKRT from January 2010 to August 2022.ResultsAmong the 53 children who received CKRT post HCT, 13 had severe SOS. The median age was 6 years; 62% were males, and most (77%) received allogeneic HCT. In this cohort, 92% required respiratory support and 85% required vasopressor support. The ICU survival rate was 62%. Survivors experienced lower cumulative FO on the 2 days following CKRT initiation (−4.2% in survivors vs. −0.5% in non‐survivors, p = 0.07). Higher urine output on D1 and D2 after discontinuation of CKRT was associated with successful liberation.ConclusionsIn this study of post‐HCT children with SOS and MOD who received CKRT, 62% survived until ICU discharge. This survival rate is encouraging as it approximates the survival rates of general pediatric cohorts treated with CKRT. Reducing FO after initiation of CKRT can improve survival in these children.
Treatment of Pediatric, Adolescent, and Young Adult Patients With Fusion‐Positive Alveolar Rhabdomyosarcoma Infiltrating Regional Lymph Nodes in the European CWS‐2002P and RMS 2005 Studies and the Soft Tissue Sarcoma Registry
Authors: Heinz Amadeus T. , Ciuffolotti Melissa , Merks Johannes H. M. , Schönstein Anton , Minard‐Colin Véronique , Fuchs Jörg , Guillen Gabriela , Timmermann Beate , Vokuhl Christian , Koscielniak Ewa , Chisholm Julia C. , Sparber‐Sauer Monika , Bisogno Gianni 
Published: December 2024

ABSTRACTBackgroundPatients with alveolar rhabdomyosarcoma (ARMS) with regional lymph node involvement (N1) are defined as “very‐high‐risk rhabdomyosarcoma” in Europe. Different chemotherapy regimens were used in European study protocols.MethodsPatients with FOXO1 fusion‐positive N1 ARMS registered in the CWS‐2002P study, the EpSSG RMS 2005 study, and SoTiSaR were retrospectively investigated. Patients received systemic treatment with chemotherapy (CHT) and local treatment of primary tumor (PT) and involved lymph nodes (LN) with radiotherapy (RT) and/or surgery. Kaplan–Meier estimators and Cox regression were used to examine event‐free survival (EFS) and overall survival (OS) according to prognostic factors and treatment.ResultsA total of 156 patients registered in RMS 2005 (n = 99), CWS‐2002P (n = 20), and SoTiSaR (n = 37) between 2003 and 2020 were eligible for this analysis. Median age at diagnosis was 10.2 years [0.1–21.9]. Treatment comprised CHT with IVADo (ifosfamide, vincristine, actinomycin‐D, doxorubicin, n = 93; 60%), VAIA (vincristine, actinomycin‐D, ifosfamide, adriamycin/doxorubicin, n = 53; 34%) or other regimens (n = 10; 6%); resection of the PT (n = 89; 57%), LN sampling or dissection (n = 92; 59%), and/or RT (n = 139; 89%). Maintenance treatment (MT) was added in n = 99/135 (73%) patients who achieved complete remission. Five‐year EFS and OS of the cohort were 45% and 47%, respectively. Age and tumor size were independent prognostic factors for EFS. Local treatment applied to the LN with surgery, RT or both significantly improved EFS (p = 0.02) and OS (p = 0.04), with no difference between the modalities (p = 0.7).ConclusionsPatients with fusion‐positive N1 ARMS carry a poor prognosis. Adequate local treatment of LN improved survival.
Mechanical behavior, energy absorption, and failure mechanism of 3D‐printed hexagonal honeycomb core under dynamic and quasi‐static loadings
Authors: Ainin F. Nur , Azaman M. D. , Abdul Majid M. S. , Ridzuan M. J. M. 
Published: December 2024

AbstractThe integration of 3D‐printed cellular cores into sandwich composite structures for load‐bearing applications opens up innovative design possibilities while improving structural efficiency. However, ensuring effective energy dissipation under impact conditions without compromising structural integrity remains a challenge. This study investigates the energy absorption and failure mechanisms of 3D‐printed hexagonal honeycomb sandwich composite structures across three different PLA‐based core materials: polylactic acid (PLA), PLA–Carbon, and PLA–Wood, under dynamic and quasi‐static loadings. Material characterization was conducted via Fourier transform infrared spectroscopy (FTIR) and scanning electron microscopy (SEM). Failure modes were analyzed using optical microscopy. The results show that PLA–Wood composites demonstrated significant improvement in energy absorption, absorbing 9.22 J of energy at an impact energy of 11 J, compared to 8.49 J for PLA–Carbon while under in‐plane compression, PLA–Wood recorded an energy absorption of 8.74 J, significantly outperforming PLA–Carbon, which reached only 3.05 J. This improvement is attributed to enhanced interfacial adhesion between the wood filler and the PLA matrix, as confirmed by SEM and FTIR analyses. These findings highlight the critical role of filler compatibility in the structural integrity of 3D‐printed sandwich composites, indicating potential applications in the aerospace and automotive industries, where lightweight and durable materials are essential for improving performance.Highlights
Dynamic and quasi‐static response of 3D‐printed hexagonal honeycomb cores.
Material interactions affect energy absorption through plastic deformation of cores.
PLA–Wood outperforms PLA–Carbon in absorbed energy due to filler compatibility.
Dynamic loading causes localized core damage with short elastic recovery.
Core failure mechanisms with long elastic recovery vary in quasi‐static tests.
Metronomic chemotherapy in pediatric neuroblastoma
Authors: Jiang Yi , Xi Chengjun , Yang Chao 
Published: December 2024

AbstractMetronomic chemotherapy (MC) is an innovative therapeutic approach that involves the chronic administration of low doses of chemotherapy agents. This strategy aims to sustain prolonged and active plasma levels of drugs, which can result in favorable tolerability. MC has shown promise in the treatment of hematologic and solid tumors, including high‐risk neuroblastoma and relapsed/refractory (R/R) neuroblastoma. In the contemporary management of neuroblastoma, MC stands as a viable maintenance therapy for newly diagnosed patients lacking access to autologous stem cell transplantation or immunotherapy, particularly in resource‐constrained regions. Furthermore, it serves as a pragmatic alternative for individuals intolerant to intensified regimens or undergoing palliative care for R/R neuroblastoma. Nevertheless, the quest for the optimal MC regimen persists, necessitating comprehensive investigations to delineate standardized protocols. Moreover, the identification of potential biomarkers or prognostic indicators assumes paramount significance in refining MC strategies for future breakthroughs in this domain. This review embarks on a comprehensive exploration of MC in neuroblastoma, offering insights into its historical underpinnings, diverse applications, adverse effect and future prospects, endeavoring to enrich our understanding of MC role in neuroblastoma management.
ERG and PTEN Role on Active Surveillance for Low‐Risk Prostate Cancer in the Multiparametric MRI Era
Authors: Yorioka Marco Aurelio Watanabe , Murta Claudio Bovolenta , Leite Kátia Ramos Moreira , Cardili Leonardo , de Mello Evandro Sobroza , de Carvalho Fazoli Arnaldo Jose , Cordeiro Maurício Dener , Coelho Rafael Ferreira , Viana Públio Cesar Cavalcante , Kohama Cesar Sadao Nicolino , Nahas William Carlos , Pontes‐Júnior José 
Published: December 2024

ABSTRACTBackgroundOur study aimed to correlate ERG and PTEN expressions in prostate biopsy with multiparametric magnetic resonance imaging PI‐RADS score, clinical reclassification, and prognosis of very low‐risk prostate cancer (PCa) patients under active surveillance (AS).MethodsWe evaluated 101 very low‐risk PCa patients under AS between 2013 and 2018. They were followed with DRE, PSA, MRI, and re‐biopsies every 1–2 years. Per cause biopsy was recommended if PSA > 10 ng/mL, suspicious DRE, or PI‐RADS ≥ 4 was present. ERG and PTEN expressions were assessed by immunohistochemistry at biopsy. Reclassification was defined by PSA > 10 ng/mL, re‐biopsy with > 3 positive cores, > 50% positive core, Gleason Score (GS) upgrading ≥ 3 + 4 or extreme GS upgrading ≥ 4 + 3. We correlated ERG and PTEN with reclassification, PI‐RADS, pathologic outcomes, and biochemical recurrence in patients surgically treated after reclassification.ResultsAfter a 49.2‐month follow‐up, 80% of patients showed reclassification, and GS upgrading was the most common criterion. Seventy‐four out of 81 patients with reclassification underwent local treatment and seven had biochemical recurrence during a mean 39.7‐month follow‐up. At biopsy, positive ERG expression was found in 39.6% of patients and PTEN loss in 12.6%. PTEN loss was associated with GS upgrading (OR = 9.7, p = 0.011) in univariate analysis. PTEN loss was correlated with GS upgrading; these patients had a 9.7‐fold greater chance of upgrading when compared to PTEN‐positive patients. ERG‐positive was associated with PI‐RADS ≥ 4 (OR = 2.8, p = 0.026). At multivariate analysis, PI‐RADS ≥ 4 was predictor of GS upgrading (OR = 25.2, p < 0.001); MRI PI‐RADS score remained an independent factor for extreme GS upgrading, together with PSAd > 0.15 (OR = 15.1, p = 0.012 and OR = 5.76, p = 0.012, respectively).ConclusionsNeither ERG‐positive nor PTEN loss were associated with upgrading during AS. ERG and PTEN biomarkers, despite commonly studied in advanced PCa, have yet no defined role in very low‐risk PCa under AS. PI‐RADS score was an independent predictor of GS upgrading and extreme upgrading during AS.
Biocontrol potential of natamycin‐producing Streptomyces lydicusJCK‐6019 against soil‐borne fungal diseases of cucumber and characterization of its biocontrol mechanism
Authors: Luo Feng , Gwak Hanna , Park Ae Ran , Nguyen Van Thi , Kim Jin‐Cheol 
Published: December 2024

AbstractBACKGROUNDFusarium oxysporum f. sp. cucumerinum and Rhizoctonia solani AG‐4 are the two most important fungal pathogens causing soil‐borne fungal diseases of cucumber; they are difficult to control and cause serious economic losses. Given the detrimental effects of the indiscriminate use of chemical fungicides, biocontrol emerges as an efficient and ecofriendly alternative for managing soil‐borne fungal diseases.RESULTSStreptomyces lydicus JCK‐6019 (hereafter, JCK‐6019) was isolated from rhizosphere soil. Its fermentation filtrate and volatile organic compounds exhibited broad‐spectrum antifungal activity against various phytopathogenic fungi and oomycetes. JCK‐6019 produced natamycin as an agar‐diffusible antifungal metabolite. It also produced indole‐3‐acetic acid and various hydrolytic enzymes. In vivo experiments revealed that a ten‐fold‐diluted optimized JCK‐6019 fermentation broth exhibited 100% control efficiency against cucumber damping‐off disease and 62.5% control efficiency against cucumber Fusarium wilt disease. Pretreatment of cucumber seedlings with 1000‐fold‐diluted optimized JCK‐6019 fermentation broth resulted in 68.18% and 23.91% disease control values against cucumber damping‐off and Fusarium wilt disease, respectively. Moreover, peroxidase activity in cucumbers after 1 day of treatment was 1.5‐fold higher than that in the control. Similarly, polyphenol oxidase activity in cucumbers after 3 days of treatment was 2.34‐fold higher than that in the control, indicating that JCK‐6019 can induce plant resistance.CONCLUSIONThe natamycin‐producing strain JCK‐6019 could effectively suppress the development of cucumber Fusarium wilt and damping‐off disease by inducing plant resistance and producing antifungal metabolites, including natamycin and volatile organic compounds. Thus, JCK‐6019 possesses high potential for application in the development of biocontrol agents against soil‐borne fungal diseases of cucumber. © 2024 Society of Chemical Industry.
Same‐Day Discharge Following Outpatient Balloon Pulmonary Angioplasty: A Single‐Center Experience
Authors: Saha Amit , Chidester Jeffrey P. , Hall Hurst M. , Shah Trushil , Chin Kelly M. , Bartolome Sonja D. , Koshy Thomas P. 
Published: December 2024

ABSTRACTOvernight inpatient monitoring is common following balloon pulmonary angioplasty (BPA) for chronic thromboembolic pulmonary hypertension (CTEPH). We describe our institutional experience in same‐day discharge (SDD) after BPA. Across 78 BPA sessions, there were only 2 (2.6%) admissions for hemoptysis with no reperfusion lung injury or deaths at 30 days.
A Fully‐Integrated Diamond Nitrogen‐Vacancy Magnetometer with Nanotesla Sensitivity
Authors: Dai Yulin , Tian Wenhui , liu Qing , Chen Bao , Liu Yushan , Hu Qidi , Ma Zheng , Zhai Yunpeng , Wang Haodong , Dong Ying , Xu Nanyang 
Published: December 2024

AbstractEnsemble diamond nitrogen‐vacancy (DNV) centers have emerged as a promising platform for precise earth‐field vector magnetic sensing, particularly in applications that require high mobility. Nevertheless, integrating all control utilities into a compact form has proven challenging, thus far limiting the sensitivity of mobile DNV magnetometers to the ‐level. This study introduces a fully integrated DNV magnetometer that encompasses all the essential components typically found in traditional platforms, while maintaining compact dimensions of approximately 13 cm 26 cm. In contrast to previous efforts, these challenges are successfully addressed by integrating a high‐power laser, a lock‐in amplifier, and a digitally‐modulated microwave source. These home‐made components show comparable performance with commercial devices under the circumstance, resulting in an optimal sensitivity approaching 2.14 nT ()−1. The limitations in this system as well as possible future improvements are discussed. This work paves the way for the use of DNV magnetometry in cost‐effective, mobile unmanned aerial vehicles, facilitating a wide range of practical applications.
Fe‐Rich Medium‐Entropy Core‐Shell Electrocatalyst for Hydrogen Evolution Reaction Under Large Current Density
Authors: Shao Yuxuan , Ni Junjie , Yin Jie , Liu Xinqing , Guo Shuai , Xu Yue , Song Bo , Song Yulai , Li Xinxin , Luo Laima , Sun Chenghua 
Published: December 2024

AbstractIn response to the low stability of expensive Pt under large current, exploring the stable, efficient and cost‐competitive electrocatalyst for hydrogen evolution reaction is crucial for advancing green hydrogen production. Here, a strategy relating to constructing the core‐shell structure with near‐zero‐resistance homogeneous interface is applied to synthesize new Fe‐rich medium‐entropy alloy (MEA) catalyst. This low‐cost sample presents both outstanding durability and catalytic activity with an overpotential of 343.6 mV at 1,000 mA cm−2 as well as Tafel slope of 67.6 mV dec−1, respectively much lower than benchmark catalyst 20%Pt/C (416.9 mV, 156.8 mV dec−1) in 1.0 m KOH solution. Such properties are attributed to the enhanced reactivity of surface active sites with electrons easy injection from MEA metallic core to MEO (medium entropy oxide) shell via their highly conductive homogeneous interface. In MEO layer, Fe/Ni/Co sites are identified as active centres and their high oxidation is crucial to shift themselves toward deep energy, weakening Metal─H bonding and thereby accelerating hydrogen evolution. This work not only exploits one novel electrocatalyst suitable for industrial high‐current environments but also provides broad application prospects for MEA utilization.
Molecularly Imprinted Nanozymes with Substrate Specificity: Current Strategies and Future Direction
Authors: Zhang Zhou , Luo Ergui , Wang Wenjuan , Huang Di , Liu Juewen , Du Zhi 
Published: December 2024

AbstractMolecular imprinting technology (MIT) stands out for its exceptional simplicity and customization capabilities and has been widely employed in creating artificial antibodies that can precisely recognize and efficiently capture target molecules. Concurrently, nanozymes have emerged as promising enzyme mimics in the biomedical field, characterized by their remarkable stability, ease of production scalability, robust catalytic activity, and high tunability. Drawing inspiration from natural enzymes, molecularly imprinted nanozymes combine the unique benefits of both MIT and nanozymes, thereby conferring biomimetic catalysts with substrate specificity and catalytic selectivity. In this review, the latest strategies for the fabrication of molecularly imprinted nanozymes, focusing on the use of organic polymers and inorganic nanomaterials are explored. Additionally, cutting‐edge techniques for generating atom‐layer‐imprinted islands with ultra‐thin atomic‐scale thickness is summarized. Their applications are particularly noteworthy in the fields of catalyst optimization, detection techniques, and therapeutic strategies, where they boost reaction selectivity and efficiency, enable precise identification and quantification of target substances, and enhance therapeutic effectiveness while minimizing adverse effects. Lastly, the prevailing challenges in the field and delineate potential avenues for future progress is encapsulated. This review will foster advancements in artificial enzyme technology and expand its applications.
3D Printing‐Induced Phase Transition in Ferroelectric Porous Polymer Coatings for Stable Zinc Anodes
Authors: Zhang Hongcheng , Zhu Guoyin , Lu Jingqi , Hou Yanan , Bao Yuwen , Liu Pin , Zhang Yizhou 
Published: December 2024

AbstractThe abundant availability of zinc and its environmentally friendly properties have increasingly drawn attention to the potential of aqueous zinc‐ion batteries (AZIBs). However, their development is hindered by the formation of zinc dendrites and severe side reactions during charge/discharge cycles. In this work, a novel strategy is introduced to address these challenges by constructing a ferroelectric porous PVDF‐HFP protective layer (PH‐ZF) on the zinc anode surface using 3D printing technology. This approach not only simplifies the fabrication process but also achieves a high content of β‐phase PVDF‐HFP without the need for post‐treatment. The ferroelectric porous polymer layer effectively regulates ion concentration distribution on the zinc anode surface, promoting uniform Zn2+ deposition. As a result, symmetric batteries exhibit cycle lifetimes of 1200 and 2000 h at current densities of 0.5 and 1.0 mA cm−2, respectively. Furthermore, full batteries with MnO2 cathodes maintained a discharge specific capacity of ≈88.3 mA g−1 after 1000 cycles at a current density of 1.0 A g−1, in contrast to bare zinc electrodes, which retain only 51 mAh g−1 under the same conditions. This method offers a promising approach for enhancing zinc anode protection and advancing ZIB performance.
Comparative Analysis of Multi‐Criteria Decision‐Making Approaches for Identifying Groundwater Recharge Potential Zones in the River Basin of Northern Kerala, India
Authors: Rasheed Shamla , Abraham Marykutty , Kavisri M. , Moovendhan Meivelu , Rasheed Ameen Abdul 
Published: December 2024

ABSTRACTGroundwater resources are increasingly strained by misuse and climate change, necessitating the identification of potential recharge zones for sustainable management. The study aimed to simulate potential recharge zones of a tropical river basin using two multi‐criteria decision‐making techniques: the Analytical Hierarchy Process (AHP) and Multi‐Influencing Factor (MIF) methods. Thematic layers of key variables were integrated using a weighted overlay analysis in GIS environment to model recharge areas within a tropical river basin in Northern Kerala, India. Normalized weights and ranks were calculated to evaluate their influence on groundwater development. Five classes of groundwater recharge potential zones (GWRPZ) with their derived areas were identified for AHP and MIF, respectively: high (30.39% and 28.24%), low (21.55% and 21.60%), very high (19.20% and 18.45%), moderate (16.96% and 20.25%), and very low (11.90% and 11.45%). Validation with overall accuracy and Kappa coefficient confirmed the methods' comparability. The results guide water well site selection and improve managed aquifer recharge (MAR) strategies. Local bodies within the river basin were ranked utilizing the Technique for Order of Preference by Similarity to Ideal Solution (TOPSIS) method to prioritize and implement recharge schemes, aiding sustainability goals in groundwater management.
State of the Art – Pharynxrekonstruktion
Authors: Brunner Markus , Haerle Stephan 
Published: December 2024

Zusammenfassung
Hintergrund
Die Rekonstruktion des Pharynx nach ablativer onkologischer Chirurgie ist anspruchsvoll. Die Wiederherstellung der Funktion und die Ästhetik stehen dabei im Mittelpunkt. Es gibt keinen klaren Goldstandard der Rekonstruktion. Die traditionell meist verwendeten freien Lappenrekonstruktionen bedienen sich eines freien Radialis- oder eines freien Oberschenkellappens. Für Defekte mittleren Ausmaßes stellt der freie laterale Armlappen eine hervorragende rekonstruktive Methode dar.

Ziel der Arbeit
Die Vor- und Nachteile der verschiedenen Rekonstruktionsmethoden werden aus der Sicht zweier erfahrener Kopf-Hals-Chirurgen diskutiert und das jeweils übliche Vorgehen bei der Pharynxrekonstruktion beschrieben.

Schlussfolgerung
Die ideale Rekonstruktion hängt von der Größe, vom Volumen des Defekts, von der Gefäßsituation und nicht zuletzt von der Präferenz und Erfahrung der Operateur:innen ab.