bluuebunny/crossref_metadata_2025_split huggingface dataset:
The High Price of Materialism
Authors: Kasser Tim 
Published: January 2019

A study of how materialism and consumerism undermine our quality of life.
In The High Price of Materialism, Tim Kasser offers a scientific explanation of how our contemporary culture of consumerism and materialism affects our everyday happiness and psychological health. Other writers have shown that once we have sufficient food, shelter, and clothing, further material gains do little to improve our well-being. Kasser goes beyond these findings to investigate how people's materialistic desires relate to their well-being. He shows that people whose values center on the accumulation of wealth or material possessions face a greater risk of unhappiness, including anxiety, depression, low self-esteem, and problems with intimacy—regardless of age, income, or culture.
Drawing on a decade's worth of empirical data, Kasser examines what happens when we organize our lives around materialistic pursuits. He looks at the effects on our internal experience and interpersonal relationships, as well as on our communities and the world at large. He shows that materialistic values actually undermine our well-being, as they perpetuate feelings of insecurity, weaken the ties that bind us, and make us feel less free. Kasser not only defines the problem but proposes ways we can change ourselves, our families, and society to become less materialistic.
Bradford Books imprint
Recycling Reconsidered
Authors: MacBride Samantha 
Published: January 2019

How the success and popularity of recycling has diverted attention from the steep environmental costs of manufacturing the goods we consume and discard.
Recycling is widely celebrated as an environmental success story. The accomplishments of the recycling movement can be seen in municipal practice, a thriving private recycling industry, and widespread public support and participation. In the United States, more people recycle than vote. But, as Samantha MacBride points out in this book, the goals of recycling—saving the earth (and trees), conserving resources, and greening the economy—are still far from being realized. The vast majority of solid wastes are still burned or buried. MacBride argues that, since the emergence of the recycling movement in 1970, manufacturers of products that end up in waste have successfully prevented the implementation of more onerous, yet far more effective, forms of sustainable waste policy. Recycling as we know it today generates the illusion of progress while allowing industry to maintain the status quo and place responsibility on consumers and local government.
MacBride offers a series of case studies in recycling that pose provocative questions about whether the current ways we deal with waste are really the best ways to bring about real sustainability and environmental justice. She does not aim to debunk or discourage recycling but to help us think beyond recycling as it is today.
Complex spike synchrony dependent modulation of rat deep cerebellar nuclear activity
Authors: Tang Tianyu , Blenkinsop Timothy A , Lang Eric J 
Published: January 2019

The rules governing cerebellar output are not fully understood, but must involve Purkinje cell (PC) activity, as PCs are the major input to deep cerebellar nuclear (DCN) cells (which form the majority of cerebellar output). Here, the influence of PC complex spikes (CSs) was investigated by simultaneously recording DCN activity with CSs from PC arrays in anesthetized rats. Crosscorrelograms were used to identify PCs that were presynaptic to recorded DCN cells (presynaptic PCs). Such PCs were located within rostrocaudal cortical strips and displayed synchronous CS activity. CS-associated modulation of DCN activity included a short-latency post-CS inhibition and long-latency excitations before and after the CS. The amplitudes of the post-CS responses correlated with the level of synchronization among presynaptic PCs. A temporal precision of ≤10 ms was generally required for CSs to be maximally effective. The results suggest that CS synchrony is a key control parameter of cerebellar output.Editorial note: This article has been through an editorial process in which the authors decide how to respond to the issues raised during peer review. The Reviewing Editor's assessment is that all the issues have been addressed (<xref ref-type="decision-letter" rid="SA1">see decision letter</xref>).
Correlation Between Physiologic and Osteopathic Measures of Sympathetic Activity in Women With Polycystic Ovary Syndrome
Authors: Davis Sarah E. , Hendryx Jan , Bouwer Stephanie , Menezes Christian , Menezes Heather , Patel Vishesha , Speelman Diana L. 
Published: January 2019

Abstract

Background
Polycystic ovary syndrome (PCOS) is a common hormone disorder that affects the reproductive, metabolic, and psychological health of reproductive-aged females, with a number of long-term health risks, including type 2 diabetes mellitus and cardiovascular sequelae. Sympathetic hyperactivity in affected persons may be involved in the pathogenesis of the disorder.

Objective
To determine whether physiologic and osteopathic measures of increased sympathetic tone correlate in a population of women with PCOS.

Methods
For this descriptive observational study, women with PCOS between the ages of 20 and 44 years were recruited. Physiologic measures of sympathetic tone (resting heart rate and blood pressure, resting heart rate variability, and postexercise heart rate recovery and blood pressure) were compared with osteopathic measures of sympathetic tone (Chapman points and viscerosomatic reflexes) for the heart, adrenal glands, and ovaries.

Results
Twenty-four women participated in the study. Overall, the participants exhibited both physiologic and osteopathic signs of increased sympathetic tone compared with reference values. In some participants, the number of osteopathic findings were greater than the number of physiologic findings of increased sympathetic tone.

Conclusions
Women with PCOS exhibit increased sympathetic tone by physiologic and osteopathic measures, indicating the utility of assessing sympathetic hyperactivity in these patients by osteopathic methods. Osteopathic structural examination is a valuable diagnostic tool that may allow detection of sympathetic hyperactivity in women with PCOS even before physiologic symptoms manifest. The osteopathic indicators of increased sympathetic tone may represent potential therapeutic targets to improve health in this population. (ClinicalTrials.gov NCT03383484)
Post-mortem detection of six human herpesviruses (HSV-1, HSV-2, VZV, EBV, CMV, HHV-6) in trigeminal and facial nerve ganglia by PCR
Authors: Ptaszyńska-Sarosiek Iwona , Dunaj Justyna , Zajkowska Agata , Niemcunowicz-Janica Anna , Król Monika , Pancewicz Sławomir , Zajkowska Joanna 
Published: January 2019

BackgroundAmong over 100 types ofHerpesviridaeviruses, eight can infect humans: herpes simplex viruses (HSV-1, HSV-2), varicella zoster virus (VZV), cytomegalovirus (CMV), Epstein-Barr virus (EBV), and human herpesviruses 6, 7, and 8 (HHV-6, HHV-7, HHV-8). After initial infection, the viruses remain latent for the lifetime of the host. The aim of this study was to determine the distribution of six different herpesviruses: HSV-1, HSV-2, VZV, EBV, CMV, and HHV-6 in trigeminal and facial nerve ganglia among a random group of Polish population.MethodsThe studied group consisted of 47 individuals (40 male, seven female); mean age of 47.4 ± 16.5 years) who died of independent causes (suicide, traffic accident, and poisoning, among others). Bilateral trigeminal and facial nerve ganglia of each cadaver were collected during the autopsy. Herpesviruses were detected using multiplex polymerase chain reaction technique.ResultsHerpesviruses were found in trigeminal and/or facial ganglia in 30/47 (63.8%) of cadavers. HHV-6 was the most prevalent of the herpesviruses and was found in nearly half of cadavers (n= 22; 46.8%), followed by HSV-1 (n= 7; 14.9%), VZV (n= 4; 8.5%), EBV (n= 4; 8.5%), HSV-2 (n= 2; 4.3%), and CMV (n= 1; 2.1%). Facial nerve ganglia (n= 23; 48.9%) were more often infected than trigeminal ganglia (n= 13; 27.7%).DiscussionThe results of this study have revealed a common presence of the herpesviruses in trigeminal and facial nerve ganglia among a random group of Polish population. Furthermore, the data also demonstrate simultaneous infection of the ganglia with different herpesviruses. This study has contributed to the knowledge of prevalence and localization of herpesviruses in different structures of the nervous system.
Brain histopathological study and prognosis in MOG antibody‐associated demyelinating pseudotumor
Authors: Shu Yaqing , Long Youming , Wang Shisi , Hu Wanming , Zhou Jian , Xu Huiming , Chen Chen , Ou Yangmei , Lu Zhengqi , Lau Alexander Y. , Yu Xinhua , Kermode Allan G. , Qiu Wei 
Published: January 2019

AbstractOur objective was to examine the brain biopsies by histopathology and investigate the prognosis of patients with myelin oligodendrocyte glycoprotein antibody‐associated demyelinating pseudotumor. The clinical, MRI, and histological features of two patients with myelin oligodendrocyte glycoprotein antibody‐associated demyelinating pseudotumor were reviewed. Both patients were treated with steroid plus rituximab and followed up. The brain biopsies of both cases revealed T cells, macrophages, and complement‐mediated demyelination, which was in accord with multiple sclerosis‐like pathology. Moreover, both cases showed favorable response to steroid plus rituximab therapy. Our cases add a new variant to the myelin oligodendrocyte glycoprotein‐encephalomyelitis spectrum, which favorably responds to immunotherapy.
Activated Platelets‐Targeting Micelles with Controlled Drug Release for Effective Treatment of Primary and Metastatic Triple Negative Breast Cancer
Authors: Zhang Yujie , Zhu Xi , Chen Xinli , Chen Qinjun , Zhou Wenxi , Guo Qin , Lu Yifei , Li Chao , Zhang Yu , Liang Donghui , Sun Tao , Wei Xunbin , Jiang Chen 
Published: January 2019

AbstractThe frequent relapse and metastasis characteristics of triple negative breast cancer (TNBC) make it a fraught issue with very poor prognosis in clinic. An effective treatment for TNBC should prevent and even eliminate metastasis as well as suppress primary lesion expansion. Recent progress reveals that platelets can be recruited and activated by tumor cells through intercellular adhesion molecules (ICAM), and help aggressive circulating tumor cells (CTCs) form metastasis. Therefore, activated platelets are considered with possession of tumor‐homing, CTC‐capturing, and metastasis‐targeting abilities. In this work, a P‐selectin (expressed on activated platelet surface) targeting peptide (PSN) is modified on a redox‐responsive paclitaxel‐loaded micelle (PSN‐PEG‐SS‐PTX4 micelle) to utilize activated platelets as a “bridge” for interaction with cancer cells. The PSN‐modified micelle can easily adhere to the surface of activated platelets and subsequently capture CTCs in blood circulation. Compared to Taxol and PEG‐SS‐PTX4 micelle, PSN‐PEG‐SS‐PTX4 micelle also exhibits enhanced primary TNBC/metastasis targeting and penetrating effect through binding with tumor infiltrating platelets and thus significantly improves treatment outcome. More importantly, PSN‐PEG‐SS‐PTX4 micelle potently suppressed lung metastasis of TNBC and reduced incidence of distant liver metastasis. The activated platelet‐targeting redox‐responsive micelle system provides a promising prospect for the omnidirectional treatment of metastatic cancer.
A Generic Soft Encapsulation Strategy for Stretchable Electronics
Authors: Li Kan , Cheng Xu , Zhu Feng , Li Linze , Xie Zhaoqian , Luan Haiwen , Wang Zhouheng , Ji Ziyao , Wang Heling , Liu Fei , Xue Yeguang , Jiang Changqing , Feng Xue , Li Luming , Rogers John A. , Huang Yonggang , Zhang Yihui 
Published: January 2019

AbstractRecent progress in stretchable forms of inorganic electronic systems has established a route to new classes of devices, with particularly unique capabilities in functional biointerfaces, because of their mechanical and geometrical compatibility with human tissues and organs. A reliable approach to physically and chemically protect the electronic components and interconnects is indispensable for practical applications. Although recent reports describe various options in soft, solid encapsulation, the development of approaches that do not significantly reduce the stretchability remains an area of continued focus. Herein, a generic, soft encapsulation strategy is reported, which is applicable to a wide range of stretchable interconnect designs, including those based on two‐dimensional (2D) serpentine configurations, 2D fractal‐inspired patterns, and 3D helical configurations. This strategy forms the encapsulation while the system is in a prestrained state, in contrast to the traditional approach that involves the strain‐free configuration. A systematic comparison reveals that substantial enhancements (e.g., ≈6.0 times for 2D serpentine, ≈4.0 times for 2D fractal, and ≈2.6 times for 3D helical) in the stretchability can be achieved through use of the proposed strategy. Demonstrated applications in highly stretchable light‐emitting diodes systems that can be mounted onto complex curvilinear surfaces illustrate the general capabilities in functional device systems.
Efficient Quaternary Organic Solar Cells with Parallel‐Alloy Morphology
Authors: Bi Zhaozhao , Zhu Qinglian , Xu Xianbin , Naveed Hafiz Bilal , Sui Xinyu , Xin Jingming , Zhang Lin , Li Tengfei , Zhou Ke , Liu Xinfeng , Zhan Xiaowei , Ma Wei 
Published: January 2019

AbstractTwo compatible donors (PBDB‐T and PTB7‐Th) and two miscible acceptors (ITIC and FOIC) are employed to deliver a parallel‐alloy morphology model in non‐fullerene‐based quaternary organic solar cells. PBDB‐T and PTB7‐Th form a parallel link with a slight adjustment of molecular packing into enhanced face‐on crystallites while ITIC disperses into discontinuous FOIC microcrystal regions to form continuous and ordered alloy‐like acceptor phases. Characterization of blend morphology highlights the parallel‐alloy model—enabled by the introduction of PBDB‐T and ITIC, which contributes to improved molecular packing and reduced domain size resulting in efficient charge generation and consistent transport channels. This successful parallel‐alloy quaternary blend morphology demonstrates an enhanced optical absorption, optimized domain size, and nanostructures toward simultaneous improvement in charge transfer and transport. Therefore, a power conversion efficiency of 12.52% is realized for a quaternary device which is 6% higher than the ternary device (PBDB‐T:PTB7‐Th:FOIC) and 12% higher than the binary device (PTB7‐Th:FOIC). Domination of quaternary devices over ternary and binary blends, which is another feasible way to realize highly efficient devices through further investigation of quaternary OSCs, is presented.
Light‐Inducible Exosome‐Based Vehicle for Endogenous RNA Loading and Delivery to Leukemia Cells
Authors: Huang Lin , Gu Ning , Zhang Xian‐En , Wang Dian‐Bing 
Published: January 2019

AbstractExosomes are a novel and promising drug delivery platform because of their endogenous origin, stability, biocompatibility, and other unique features. As the efficient loading and delivery of long RNA to target cells for therapeutic purposes remains challenging, a new exosome‐based RNA delivery system is proposed using a controllable RNA enrichment and releasing protocol. The system employs RNA aptamer–protein interactions and reversible light‐inducible protein–protein interaction modules by remolding exosome producer cells. Endogenous microRNA 21 (miR‐21) sponges, inhibitors of miR‐21, are successfully enriched on the plasma membrane and are sorted into exosomes by the biogenesis of the exosomes. The loading capacity of miR‐21 sponges is enhanced by 14‐fold in the light‐inducible loading system. In addition, targeted delivery of miR‐21 to leukemia cells is achieved by modifying exosomes with the cholesterol‐conjugated aptamer AS1411, resulting in significant cell apoptosis by blocking the function of miR‐21 in leukemia cells. This work provides an exosome‐based light‐inducible vehicle to efficiently load and deliver long endogenous RNA, which can enable more RNA‐based therapeutics for personalized cancer medicine.
Exceptional Water Desalination Performance with Anion‐Selective Electrodes
Authors: Arulrajan Antony C. , Ramasamy Deepika L. , Sillanpää Mika , van der Wal Albert , Biesheuvel P. Maarten , Porada Slawomir , Dykstra Jouke E. 
Published: January 2019

AbstractCapacitive deionization (CDI) typically uses one porous carbon electrode that is cation adsorbing and one that is anion adsorbing. In 2016, Smith and Dmello proposed an innovative CDI cell design based on two cation‐selective electrodes and a single anion‐selective membrane, and thereafter this design was experimentally validated by various authors. In this design, anions pass through the membrane once, and desalinated water is continuously produced. In the present work, this idea is extended, and it is experimentally shown that also a choice for anion‐selective electrodes, in combination with a cation‐selective membrane, leads to a functional cell design that continuously desalinates water. Anion‐selective electrodes are obtained by chemical modification of the carbon electrode with (3‐aminopropyl)triethoxysilane. After chemical modification, the activated carbon electrode shows a substantial reduction of the total pore volume and Brunauer–Emmett–Teller (BET) surface area, but nevertheless maintains excellent CDI performance, which is for the first time that a low‐porosity carbon electrode is demonstrated as a promising material for CDI.
Textured Poling of the Ferroelectric Dielectric Layer for Improved Organic Field‐Effect Transistors
Authors: Laudari Amrit , Pickett Alec , Shahedipour‐Sandvik Fatemeh , Hogan Kasey , Anthony John E. , He Xiaoqing , Guha Suchismita 
Published: January 2019

AbstractPolymer ferroelectrics are playing an increasingly active role in flexible memory application and wearable electronics. The relaxor ferroelectric dielectric, poly(vinylidene fluoride trifluorethylene (PVDF‐TrFE), although vastly used in organic field‐effect transistors (FETs), has issues with gate leakage current especially when the film thickness is below 500 nm. This work demonstrates a novel method of selective poling the dielectric layer. By using solution‐processed 6,13‐bis(triisopropylsilylethynyl)pentacene (TIPS‐pentacene) as the organic semiconductor, it is shown that textured poling of the PVDF‐TrFE layer dramatically improves FET properties compared to unpoled or uniformly poled ferroelectric films. The texturing is achieved by first vertically poling the PVDF‐TrFE film and then laterally poling the dielectric layer close to the gate electrode. TIPS‐pentacene FETs show on/off ratios of 105 and hole mobilities of 1 cm2 Vs−1 under ambient conditions with operating voltages well below −5 V. The electric field distribution in the dielectric layer is simulated by using finite difference time domain methods.
Synthesis of Halogenated Cyclic Enamines from Cyclic N‐2‐En‐4‐ynyl‐N‐1‐ynylamides and N‐Propargyl‐N‐1‐ynylamides via a Tandem Iron Halide Promoted N‐to‐C Shift‐Aza‐Prins Cyclization Sequence
Authors: Lin Hsin‐Hui , Chiang Tai‐Ching , Wu Rong‐Xuan , Chang Yi‐Mei , Wang Hao‐Wen , Liu Ssu‐Ting , Yeh Ming‐Chang P. 
Published: January 2019

AbstractA facile and efficient N‐to‐C allyl shift‐aza‐Prins cyclization sequence of cyclic N‐2‐en‐4‐ynyl‐N‐1‐ynylamides is promoted by iron(III) chloride, generating chloro‐containing bridged bicyclic enamines in minutes and in high yields. This reaction involves an unprecedented formation of a ketenimine via Fe(III)‐mediated N‐to‐C allyl rearrangement, followed by aza‐Prins cyclization. This sequence can also be applied to the generation of brominated cyclobutenamine derivatives using Fe(III) bromide and N‐propargyl‐N‐1‐ynylamides.magnified image
Organocatalytic Asymmetric Cyclization Reaction of 2‐Alkynyl‐3,3‐Difluoro‐3H‐Indoles and 2‐Mercaptoimidazoles: Access to gem‐Difluorinated C2‐Spiro Indolines
Authors: Luo Jian , Fang Yu‐Bo , Mao Xiang‐Yu , Yang Meng , Zhao Yu‐Lei , Liu Yun‐Lin , Chen Guo‐Shu , Ji Yong‐Fei 
Published: January 2019

AbstractWe reported a cupreidine catalyzed enantioselective cascade cyclization reaction of 2‐alkynyl‐3,3‐difluoro‐3H‐indole and 2‐mercaptoimidazole under simple and mild conditions. The corresponding chiral gem‐difluorinated C2‐spiro indolines were obtained in moderate to good yields and enantioselectivities, which could be interesting compounds from synthetic and medicinal chemistry points of view. This work represents the first catalytic enantioselective example of utilizing 2‐alkynyl‐3,3‐difluoro‐3H‐indoles as the bis‐electrophiles in a cyclization reaction.magnified image
Organocatalytic Asymmetric Synthesis of Cyclic Compounds Bearing a Trifluoromethylated Stereogenic Center: Recent Developments
Authors: He Xiang‐Hong , Ji Yan‐Ling , Peng Cheng , Han Bo 
Published: January 2019

AbstractThe broad prospects of trifluoromethylated compounds in materials science, agricultural chemistry, and pharmaceutical chemistry have stimulated the rapid development of asymmetric organocatalytic transformations to access these biologically important compounds. Among all types of trifluoromethylated compounds, trifluoromethylated cyclic compounds with a C−CF3 stereogenic center have gained increasing attention in medicinal and organic chemistry because they are extensively found in many biologically active molecules, lead compounds, and listed drugs. This review attempts to summarize the developments in the organocatalytic asymmetric synthesis of cyclic compounds bearing a trifluoromethylated stereogenic center since 2012.magnified image
Iodine‐Catalyzed Oxidative Rearrangement of Amines to α‐Amino Acetals and α‐Amino Aldehydes
Authors: Zhou Min‐Jie , Zhu Shou‐Fei , Zhou Qi‐Lin 
Published: January 2019

AbstractA protocol for iodine‐catalyzed oxidative rearrangement of tertiary and secondary amines has been developed. This metal‐free protocol provides an atom‐economical, efficient access to synthetically useful α‐amino acid derivatives from readily available acyclic and cyclic tertiary or secondary amines.magnified image
Design Guidelines for Micro‐Thermoelectric Devices by Finite Element Analysis
Authors: Lara Ramos David Alberto , Barati Vida , Garcia Javier , Reith Heiko , Li Guodong , Pérez Nicolás , Schierning Gabi , Nielsch Kornelius 
Published: January 2019

AbstractEnergy harvesting and thermal management are required for applications in the internet‐of‐things, autarkic sensors, or highly integrated electronic devices. Thermoelectric devices, both generators and coolers, are promising specialized technologies for localized energy harvesting and thermal management. These devices are well optimized for near‐room temperature operation at the macroscopic scale. However, the high integration density of today's most significant applications requires an increasing degree of miniaturization. Understanding the design guidelines for micro‐thermoelectric devices with realistic materials properties, and with concurring size and geometry constraints, is a challenge that has not been fully addressed up to now. Here, finite element analysis is used to understand the interplay between thermal and electrical heat fluxes in micro‐thermoelectric devices. The relevant design guidelines for metallic top and bottom contacts and thermoelectric elements, as well as an optimal packing density of the thermoelectric elements are identified. The results demonstrate that on the micrometer scale, the effects of net electrical and thermal resistances of the individual components of the devices (i.e., thermoelectric leg, top, and bottom contacts) are of comparable magnitude. This makes it necessary to apply design strategies specific to the micrometer scale, in order to geometrically optimize the device.