bluuebunny/crossref_metadata_2025_split huggingface dataset:
The interplay between multisensory integration and perceptual decision making
Authors: Mercier Manuel R. , Cappe Celine 
Published: January 2019

AbstractFacing perceptual uncertainty, the brain combines information from different senses to shape optimal decision making and to guide behavior. Despite overlapping neural networks underlying multisensory integration and perceptual decision making, the process chain of decision formation has been studied mostly in unimodal contexts and is thought to be supramodal. To reveal whether and how multisensory processing interplay with perceptual decision making, we devised a paradigm mimicking naturalistic situations where human participants were exposed to continuous cacophonous audiovisual inputs containing an unpredictable relevant signal cue in one or two modalities. Using multivariate pattern analysis on concurrently recorded EEG, we decoded the neural signatures of sensory encoding and decision formation stages. Generalization analyses across conditions and time revealed that multisensory signal cues were processed faster during both processing stages. We further established that acceleration of neural dynamics was directly linked to two distinct multisensory integration processes and associated with multisensory benefit. Our results, substantiated in both detection and categorization tasks, provide evidence that the brain integrates signals from different modalities at both the sensory encoding and the decision formation stages.
TargetSeeker-MS: A Computational Method for Drug Target Discovery using Protein Separation Coupled to Mass Spectrometry
Authors: Lavallée-Adam Mathieu , Pelletier Alexander , Diedrich Jolene K. , Low William , Pinto Antonio F. M. , Martínez-Bartolomé Salvador , Petrascheck Michael , Moresco James J. , Yates John R. 
Published: January 2019

ABSTRACTWhen coupled to mass spectrometry (MS), energetics-based protein separation (EBPS) techniques, such as thermal shift assay, have shown great potential to identify the targets of a drug on a proteome scale. Nevertheless, the computational analyses assessing the confidence of drug target predictions made by these methods have remained rudimentary and significantly differ depending on the protocol used to produce the data. To identify drug targets in datasets produced using different EBPS-MS techniques, we have developed a novel flexible computational approach named TargetSeeker-MS. We showed that TargetSeeker-MS reproducibly identifies known and novel drug targets inC. elegansand HEK293 samples that were treated with the fungicide benomyl and processed using two different EBPS techniques. We also validated a novel benomyl target in vitro. TargetSeeker-MS, which is available online, allows for the confident identification of targets of a drug on a proteome scale, thereby facilitating the evaluation of its clinical viability.
Therapeutic potential of inhibition of the neuroinflammation induced cathepsin X:in vivoevidence
Authors: Pišlar Anja , Tratnjek Larisa , Glavan Gordana , Zidar Nace , Živin Marko , Kos Janko 
Published: January 2019

AbstractParkinson’s disease (PD) is a progressive neurodegenerative disorder with unknown cause, but it has been postulated that chronic neuroinflammation may play a role in its pathogenesis. Microglia-derived lysosomal cathepsins have been increasingly recognized as important inflammatory mediators. Here, we analyzed the regional distribution and cellular localization of the cathepsin X in the rat brain with neuroinflammation-induced neurodegeneration. Unilateral injection of lipopolysaccharide (LPS) into the striatum induced strong upregulation of cathepsin X expression and its activity in the ipsilateral striatum. In addition to the striatum, cathepsin X overexpression was detected in other areas such as cerebral cortex, corpus callosum, subventricular zone and external globus pallidus mainly restricted to glial cells. Moreover, continuous administration of the cathepsin X specific inhibitor AMS36 showed protective effects against LPS-induced striatal degeneration, as seen by the decreased extent of striatal lesion and decreased expression of neuroinflammation marker. These results demonstrate that glial upregulated cathepsin X may play a role as a potential pathogenic factor in PD. Inhibition of cathepsin X enzymatic activity thus may be useful in preventing neuroinflammation-induced neurodegeneration.
An EEG study of Detection without Localisation in Change Blindness
Authors: Scrivener Catriona L. , Malik Asad , Marsh Jade , Lindner Michael , Roesch Etienne B. 
Published: January 2019

AbstractPrevious studies of change blindness have suggested a distinction between detection and localisation of changes in a visual scene. Using a simple paradigm with an array of coloured squares, the present study aimed to further investigate differences in event-related potentials (ERPs) between trials in which participants could detect the presence of a colour change but not identify the location of the change (sense trials), versus those where participants could both detect and localise the change (localise trials). Individual differences in performance were controlled for by adjusting the difficulty of the task in real time. Behaviourally, reaction times for sense, blind, and false alarm trials were distinguishable when comparing across levels of participant certainty. In the EEG data, we found no significant differences in the visual awareness negativity ERP, contrary to previous findings. In the N2pc range, both awareness conditions (localise and sense) were significantly different to trials with no change detection (blind trials), suggesting that this ERP is not dependent on explicit awareness. Within the late parietal positivity range, all conditions were significantly different. These results suggest that changes can be ‘sensed’ without knowledge of the location of the changing object, and that participant certainty scores can provide valuable information about the perception of changes in change blindness.
The antimicrobial peptide Defensin cooperates with Tumour Necrosis Factor to drive tumour cell death in Drosophila
Authors: Parvy Jean-Philippe , Yu Yachuan , Dostalova Anna , Kondo Shu , Kurjan Alina , Bulet Philippe , Lemaitre Bruno , Vidal Marcos , Cordero Julia B. 
Published: January 2019

AbstractAntimicrobial peptides (AMPs) are small cationic molecules best known as mediators of the innate defence against microbial infection. While in vitro and ex vivo evidence suggest AMPs’ capacity to kill cancer cells, in vivo demonstration of an anti-tumour role of endogenous AMPs is lacking. Using a Drosophila model of tumourigenesis, we demonstrate a role for the AMP Defensin in the control of tumour progression. Our results reveal that Tumour Necrosis Factor mediates exposure of phosphatidylserine (PS), which makes tumour cells selectively sensitive to the action of Defensin remotely secreted from tracheal and fat tissues. Defensin binds tumour cells in PS-enriched areas, provoking cell death and tumour regression. Altogether, our results provide the first in vivo demonstration for a role of an endogenous AMP as an anti-cancer agent, as well as a mechanism that explains tumour cell sensitivity to the action of AMPs.
Craniofacial allometry is a rule in evolutionary radiations of placentals
Authors: Andrea Cardini 
Published: January 2019

AbstractIt has been suggested that larger species of mammals tend to become long-faced when they diverge in size during an evolutionary radiation. However, whether this allometric pattern, reminiscent of ontogenetic changes in skull proportions, is indeed a rule has yet to be thoroughly tested. Using ~6000 adult specimens from 14 phylogenetically well separated and ecomorphologically distinctive lineages, 11 orders, and all superorders of the placentals, I tested each group for positive craniofacial allometry (CREA). The evidence supporting CREA is overwhelming, with virtually all analyses showing proportionally longer faces in bigger species. This corroborates previous studies in other groups, consolidates CREA as a pervasive morphological trend in placental evolution and opens important research avenues for connecting micro- and macro-evolution. If found in even more lineages of non-placental mammals, confirmed in birds, and possibly discovered in other tetrapods, CREA could become one of the most general rules of morphological evolution in land vertebrates.
Pain sensitivity and athletic performance
Authors: Zeller Lior , Shimoni Nadav , Vodonos Alina , Sagy Iftach , Barski Leonid , Buskila Dan 
Published: January 2019

AbstractPurpeseTo determine whether higher pain thresholds are associated with better performance in long-distance runners.DesignCross-sectional study.MethodsSeventy participants, divided into groups of fast and non-fast runners according to peak results in a 10km run. Main Outcome Measures, Cold pressor test.ResultsOf the 70 subjects, 28 were in the fastest group (less than 39 minutes in a 10km run) and 42 in the non-fast group. The faster group was characterized with older age (34.0±8.5 vs. 29.5±5.7, p=0.01), greater mean weekly running time (5.5 (0-17) vs. 2 (0- 10), p<0.001), and more years of running [10 (1.5-34.0) vs. 7 (0-20, p=0.05)]. In a multivariable analysis longer cold pressor time was associated with faster 10Km run (O.R 1.01, 95% C.I 1.00-1.01).ConclusionsIt seems that higher pain thresholds play an important role in the superior ability of long distance runners.
First report of enhanced contents of nine macro- and micronutrients in gymnosperms via arbuscular mycorrhizal fungi
Authors: Franco Alicia , Pérez-Moreno Jesús , Sánchez Gabriela , Cerdán Carlos R. , Almaraz Juan J. , Cetina Víctor M. , Alarcón Alejandro 
Published: January 2019

AbstractTraditionally, it is thought that arbuscular mycorrhizae establish a mutualist symbiosis only with the roots of angiosperm plants. In this mutualism, fungi receive carbon from the plants, and angiosperms receive nutrients through the external mycelium of the arbuscular mycorrhizal fungi (AMF). However, the enhanced contents of macro- and micronutrients in gymnosperm plants, and therefore the mutualistic relationship, with AMF has not been reported so far. The present work evaluated whether arbuscular mycorrhizae were able to establish and enhance 9 nutrient contents in the neotropical Pinaceae species Pinus greggii. The tree seedlings were inoculated with three consortia of AMF isolated from an agricultural site, a forest of Cupressus lusitanica and a forest of Pinus hartwegii. The effect of AMF inoculation on plant growth and nutrient enhancement, in addition to colonization, was evaluated. There was evidence of enhancement of plant growth and 9 macro- and micronutrients in plants inoculated with the three evaluated consortia. After 7 months, the translocation was greater for Mg, Mn and Zn in plants inoculated with the consortium of AMF from pine forest. The presence of hyphae, vesicles and arbuscules was detected in the roots of the Pinus greggii plants inoculated with the AMF consortia. In addition to these positive effects, colonization of 10 to 15% and 20 to 38% was observed depending on the AMF consortia after 2 and 7 months, respectively. The presence of arbuscules which is the translocation structure among involved symbionts was also recorded; and photographed for the first time. In the present work, we report for the first time that arbuscular mycorrhiza affects the mobilization of N, P, K, Ca, Mg, Fe, Mn, Zn, Cu and B in gymnosperms, indicating that this mycorrhizal symbiosis is more complex than previously believed.
Factors that influence individuals’ intentions to purchase family takaful mediating role of perceived trust
Authors: Aziz Shahab , Md Husin Maizaitulaidawati , Hussin Nazimah , Afaq Zahra 
Published: January 2019

PurposeThe purpose of this paper is to investigate the factors that affect one’s attitude and intentions towards family takaful schemes, apart from evaluating the mediating role of perceived trust in the relationship between perceived religiosity and attitude towards family takaful. Most prior studies have considered religiosity as an individual’s tendency to be religious. However, the present study employed perceived religiosity as one’s perception regarding shariah compliance practices of family takaful schemes. Moreover, this study examines the direct relationship between perceived religiosity and attitude and the indirect relationship between perceived religiosity and trust.Design/methodology/approachA sample of 224 salaried individuals was selected with an age range of 24–50. Variance-based partial least squares structural equation modelling was employed for data analysis.FindingsThe results showed that knowledge and perceived usefulness (PU) had significantly positive relationships with attitude towards family takaful schemes. Perceived trust completely mediated the relationship between perceived religiosity and attitude towards family takaful. Attitude was positively related to purchase intention regarding family takaful.Practical implicationsThe findings of the study are important for Islamic financial institutions, especially for takaful companies to revamp their marketing strategies. With enhanced understanding regarding consumer behaviour, takaful companies can sell their products in a more effective manner to increase their market share.Originality/valueBehavioural aspects regarding the purchase of Islamic insurance products have yet to be profoundly explored in the literature. The indirect relationship between perceived religiosity and trust is established in this study. The study contributes to the field of consumer behaviour and marketing of Islamic financial products.
Co-creation and co-destruction of experiential value: a service perspective in projects
Authors: Fuentes Marcos E.G. 
Published: January 2019

Purpose
One way in which to induce an advantageous position is to improve the value outcomes experienced from commissioned projects. The purpose of this paper is to consider project stakeholders, such as end-users, as active co-creators of value. This may be achieved by taking into account interactive capabilities and service design practices. This may influence experiential and financial value outcomes for a range of project stakeholders.

Design/methodology/approach
A single case displayed as a pilot study helps to establish the transferability of the co-creation and the service experience to the construction context.

Findings
Findings show that project managers pay insufficient attention to the service experience. The analysis demonstrates users are treated as destroyers of value, rather than as co-creators of value. In addition to this, the findings suggest contextual aspects, such as unethical behaviour, misalignment of values, power asymmetry and lack of contextual awareness, may ultimately affect the project outcomes.

Practical implications
The implication for the construction context is to create awareness of interactive capabilities and service design practices, which permit the enhancement of experimental value outcomes.

Originality/value
Service-dominant logic is used as a variant perspective to analyse the project usefulness and benefits for a range of stakeholders. The originality comes from the initial exploration of how benefits could be collaboratively configured through interactive capabilities and service design practices with a range of stakeholders.
Severe alcohol withdrawal syndrome: review of the literature
Authors: Benson George , Roberts Nicola , McCallum Jacqueline , McPherson Andrew 
Published: January 2019

PurposeThe purpose of this paper is to identify published literature from a general hospital setting that may highlight variables implicated in the development of severe alcohol withdrawal syndrome (SAWS) in patients who have alcohol dependence syndrome (ADS).Design/methodology/approachA systematic literature review was carried out using the electronic databases: MEDLINE, Medline in Process, Cinahl, Embase and PsycINFO from 1989 to 2017. The focus of this search was on English language studies of individuals over 16 years admitted to general hospital with ADS, delirium tremens (DTs), alcohol-related seizure (ARS) or alcohol withdrawal syndrome (AWS).FindingsOf the 205 studies screened, eight met the criteria for inclusion. Six studies were quantitative retrospective cohort and two were retrospective case-control. Six studies investigated risk factors associated with DTs, one examined SAWS and one alcohol kindling. Descriptive analysis was performed to summarise the empirical evidence from studies were 22 statistically significant risk factors were found; including the reason for admission to hospital, daily alcohol consumption, previous DTs and prior ARS. The last two factors mentioned appeared in two studies.Research limitations/implicationsFurther research should consider the quality and completeness of the alcohol history data and competence of staff generating the data in retrospective studies.Originality/valueThe paper suggests that the factors linked to SAWS development from the literature may not fully explain why some individuals who have ADS develop SAWS, and others do not.
Investigating the links between resilience, perceived HRM practices, and retirement intentions
Authors: Salminen Hanna , von Bonsdorff Mikaela , von Bonsdorff Monika 
Published: January 2019

PurposeHuman resource management (HRM) scholars’ interest in older employees’ resilience has only recently started to emerge. Little is known about how resilience and perceived HRM are linked to different retirement intentions. Drawing on the conservation of resources and social exchange theories, the purpose of this paper is to investigate the links between perceived HRM practices, resilience and retirement intentions. Additionally, the paper examines the possible mediating role of resilience in the relationship between perceived HRM practices and retirement intentions.Design/methodology/approachIn 2016, a cross-sectional study was conducted among older (50+) nursing professionals working in a Finnish university hospital. Statistical methods, including mean comparisons and linear and logistic regression analyses, were used to analyze the data.FindingsThe results indicated that resilience partly mediated the relationship between perceived HRM practices and early retirement intentions, and fully mediated the association between perceived HRM practices and intentions to continue working after retirement age.Originality/valueThis study produces new knowledge regarding the links between resilience, perceived High involvement work practices and retirement intentions.
Predicting entrepreneurial intention across the university
Authors: Bell Robin 
Published: January 2019

PurposeThe purpose of this paper is to quantify the relative importance of four key entrepreneurial characteristics identified in the literature (proactiveness, attitude to risk, innovativeness and self-efficacy) in predicting students’ entrepreneurial intention (EI) across a range of faculties offering different subjects at a UK higher education institution (HEI). This approach will help to identify whether there are variations across the faculties in the predictors of EI. This enables recommendations to be made with regard to the development of educational delivery and support to encourage and develop the specific predictors of EI within the different subject areas.Design/methodology/approachThis research uses a 40-item questionnaire to obtain information on students’ demographics, entrepreneurial characteristics and EI, based on a five-point Likert-type scale. Principle component analysis, correlation analysis and multiple hierarchical regression analysis are used to analyse the data from 1,185 students to develop models which predict EI for each of the six faculties.FindingsIndividual models which predict EI are developed for each of the six faculties showing variations in the makeup of the predictors across faculties in the HEI. Attitude to risk was the strongest predictor in five of the six faculties and the second strongest predictor in the sixth. The differences, together with the implications, for educational approaches and pedagogy are considered.Originality/valueThis research breaks down the level of analysis of EI to the individual faculty level in order to investigate whether different entrepreneurial characteristics predict EI in different academic disciplines across a UK HEI. This enables entrepreneurship educational approaches to be considered at a faculty level rather than a one size fits all approach.
English language and graduate employability
Authors: Zainuddin Siti Zaidah Binti , Pillai Stefanie , Dumanig Francisco Perlag , Phillip Adriana 
Published: January 2019

PurposeThe purpose of this paper is to examine the perspectives of Malaysian employers and students on the need for English language proficiency and skills for employment.Design/methodology/approachInterviews were conducted with employers from various organisations. Additionally, questionnaires were disseminated to undergraduates at four public universities in Malaysia. These were done to ascertain the perspectives of different stakeholders on the importance of English in securing employment, the effect of a marked regional accent or dialect on employability and industry’s expectations and requirements for new employees.FindingsEmployers and students agree that English plays a major role in employability. Whilst there was general agreement by both parties that good grammar and a wide range of vocabulary are important, the findings indicated several mismatches in terms of students’ perceptions and employers’ expectations. Among them is the use of the colloquial form of English at the workplace which was not favoured by employers. Employers also generally felt that knowledge of different types of writing styles could be learnt on-the-job. Furthermore, employers pointed out other essential skills for employability: the ability to communicate in other languages, confidence and a good attitude.Practical implicationsCognisant of the fact that English is essential in improving employability, initiatives to improve the level of English among Malaysian students must continue to be put in place. University students should be made aware of the different language skills sought by employers early in their university education. The mismatches between the perceptions of university students and the expectations of employers should be considered when planning English language courses and degree programmes. More structured feedback from industry on both would help to better prepare students for the world of work and to ease the transition from campus to career.Social implicationsIn relation to graduate employability, these English-language elite groups would have an advantage in securing employment especially in multinational companies, and this will, in a long run, create a larger gap between students from the international and public schools.Originality/valueWith the standpoint of two important parties, employers and students, a more comprehensive idea of the effect of English language on employability has been obtained.