bluuebunny/crossref_metadata_2025_split huggingface dataset:
Is TAFRO syndrome a subtype of idiopathic multicentric Castleman disease?
Authors: Fujimoto Shino , Sakai Tomoyuki , Kawabata Hiroshi , Kurose Nozomu , Yamada Sohsuke , Takai Kazue , Aoki Sadao , Kuroda Junya , Ide Makoto , Setoguchi Keigo , Tsukamoto Norifumi , Iwao‐Kawanami Haruka , Kawanami Takafumi , Mizuta Shuichi , Fukushima Toshihiro , Masaki Yasufumi 
Published: June 2019

AbstractCastleman disease (CD) is a rare lymphoproliferative disorder that can be unicentric or multicentric. Multicentric CD (MCD) is further subdivided into human herpesvirus type‐8‐associated, POEMS syndrome‐associated, and idiopathic (iMCD). TAFRO syndrome is a newly identified disorder of unknown etiology characterized by thrombocytopenia, anasarca, fever, reticulin myelofibrosis, renal dysfunction, and organomegaly. The TAFRO syndrome is sometimes regarded as a subtype of iMCD (TAFRO‐iMCD), whereas iMCD without TAFRO syndrome is considered “not otherwise specified” (iMCD‐NOS). However, a proportion of patients with TAFRO syndrome have been diagnosed without lymph node biopsies (TAFRO syndrome without proven iMCD; TAFRO‐w/op‐iMCD). To clarify the clinical features of iMCD‐NOS, TAFRO‐iMCD, and TAFRO‐w/op‐iMCD, we retrospectively analyzed 220 patients extracted from the database of the Multicenter Collaborative Retrospective Study for Establishing the Concept of TAFRO Syndrome. The patients included 87 with iMCD‐NOS, 63 with TAFRO‐iMCD, and 19 with TAFRO‐w/op‐iMCD. Patients in all three groups exhibited anemia, hypoalbuminemia, and elevated serum C‐reactive protein and interleukin‐6 levels. No significant differences in clinical, laboratory, and prognostic features were noted between the TAFRO‐iMCD, and TAFRO‐w/op‐iMCD groups. However, the iMCD‐NOS group exhibited polyclonal hyper‐γ‐globulinemia. The five‐year survival rates of patients in the iMCD‐NOS and TAFRO‐involved groups were 100% and 66.5%, respectively (dropping markedly during the first few months in the latter). The iMCD‐NOS and the TAFRO‐iMCD samples typically showed plasma cell and mixed‐type histologies, respectively. Thus, iMCD can be classified into two distinct subtypes, iMCD‐NOS and TAFRO‐iMCD. As such, TAFRO‐iMCD and TAFRO‐w/op‐iMCD may be considered the same entity, requiring prompt diagnosis and intensive care.
Workplace breastfeeding support and job satisfaction among working mothers in the United States
Authors: Whitley Margaret D. , Ro Annie , Choi BongKyoo 
Published: June 2019

AbstractBackgroundJob satisfaction is associated with health and productivity. Workplace support for breastfeeding may affect working mothers’ job satisfaction.MethodsWe analyzed responses from 488 women from the Infant Feeding Practices Study II (2005‐2007). Using logistic regression, we assessed whether workplace breastfeeding problems at 3 months postpartum were related to low job satisfaction concurrently and, for a subsample (n = 265), at 9 and 12 months postpartum.ResultsCompared with women reporting no problems, women reporting three or more problems had higher odds (odds ratio [OR] = 4.76; 95% confidence interval [CI]: 2.03‐11.18) of low job satisfaction at 3 months, and at 12 months (OR = 6.88, 95% CI: 1.33‐35.58) after controlling for baseline job satisfaction. Models isolating problems with break time and space to pump/nurse showed more modest results.ConclusionsWork‐related breastfeeding problems at 3 months postpartum were associated with low job satisfaction concurrently and at follow‐up. Improving workplace breastfeeding accommodations could improve mothers’ job satisfaction.
The impact of industry and body part injured on repeat workers’ compensation claims
Authors: Keteyian Courtland , Schwatka Natalie , Dally Miranda , Tran Molly , Shore Erin , Weitzenkamp David , Newman Lee S. 
Published: June 2019

AbstractBackgroundFew studies investigate the influence of body part injured and industry on future workers' compensation claims.MethodsUsing claims incurred from 1 January 2005 to 31 July 2015 (n = 77 494) from the largest workers' compensation insurer in Colorado, we assessed associations between worker characteristics, second claims involving any body part and the same body part. We utilized Cox proportional hazards models to approximate the probability of a second claim.ResultsFirst claims represented 74.9% (n = 58 007) and second claims 25.2% (n = 19 487) of total claims. Sex, age, industry, and body part of the first claim were associated with the probability of second claims and the body part affected. The 5‐year probabilities of second claims and same body part second claims were 27.0% (95% confidence interval [CI]: 26.6%‐27.5%) and 6.2% (95% CI: 5.9%‐6.5%) in males and 26.5% (95% CI: 26.0%‐27.0%) and 6.7% (95% CI: 6.5%‐7.0%) in females. Most second claims occurred within 3 years.ConclusionsMost second claims occur within 3 years. Body part and industry‐specific injury patterns suggest missed opportunities for prevention.
Change in prevalence of asbestos‐related disease among sheet metal workers 1986 to 2016
Authors: West Gavin H. , Sokas Rosemary K. , Welch Laura S. 
Published: June 2019

AbstractBackgroundA medical screening program began in 1986 for sheet metal workers exposed to asbestos, primarily while working alongside insulators applying spray‐on asbestos materials, a practice banned in 1973. Exposure continues during maintenance, renovation, and repair.MethodsRadiographic abnormalities among 26 397 sheet metal workers examined from 1986 to 2016 were analyzed by year of entry into the trade. Logistic regression was used to examine risk factors for parenchymal and pleural abnormalities among the overall study population and among the subcohort who entered the trade after 1973.ResultsPrevalence of parenchymal disease was 17.4% for those starting work before 1950 compared with 0.8% for those starting work after 1973 (adjusted prevalence odds ratio [pOR] = 26.65, 95% confidence interval [CI] = 18.46‐38.46). For each calendar year after 1973, entering the trade 1 year later was associated with an estimated 12.7% decreased odds of acquiring asbestos‐related disease (adjusted pOR = 0.873, 95% CI = 0.832‐0.916).ConclusionSheet metal workers who began work after the US implemented environmental and occupational regulations develop asbestos‐related disease at much reduced rates, consistent with regulatory projections made for nonmalignant asbestos‐related disease by the Occupational Safety and Health Administration at the time. Cancer remains a concern among this cohort, and lung cancer screening recommendations should consider year of entry into the trade. This study highlights the importance of regulatory intervention and of continued surveillance.
Evidence of genetic monogamy in the lemur Indri (Indri indri)
Authors: Bonadonna Giovanna , Torti Valeria , De Gregorio Chiara , Valente Daria , Randrianarison Rose Marie , Pozzi Luca , Gamba Marco , Giacoma Cristina 
Published: June 2019

AbstractMonogamy is a rare strategy among mammals but relatively common among primates. The study of the evolution of monogamy in mammals and primates is lacking empirical studies that assess the relationship between a pair‐living social organization and genetic monogamy. Sexual or genetic monogamy can only be assessed by performing molecular analyses and investigating rates of extra‐pair paternity (EPP). Studying the occurrence of EPP can provide valuable insights into reproductive strategies and their adaptive value. The indri is a pair‐living primate that lives in stable groups. Their social units are composed of the reproductive pair and up to four more individuals, but extra‐pair copulation (EPC) can occur. This raises the question of whether this event may or may not lead to EPP. Here, we investigated whether a pair‐living social organization corresponds to genetic monogamy in indris (Indri indri). We analyzed the paternity of 12 offspring from seven pairs using a set of six microsatellite loci on fecal samples (mean number of alleles 11.7 ± 1.8 (mean ± standard deviation). We found that in 92% of cases the genetic profile of the offspring matched the paired male of the group for all the loci considered. In the only case of paternity mismatch, the paternity assignment remained inconclusive. Our results show thatI. indrigenetic monogamy is the norm and supports the hypothesis that pair‐living social organization is associated with low EPP rate. Also, our results are in contrast with the hypothesis of infertility as a reason to engage in EPC for this species.
Terminal Diazirines Enable Reverse Polarization Transfer from 15N2 Singlets
Authors: Zhang Guannan , Colell Johannes F. P. , Glachet Thomas , Lindale Jacob R. , Reboul Vincent , Theis Thomas , Warren Warren S. 
Published: June 2019

AbstractDiazirine moieties are chemically stable and have been incorporated into biomolecules without impediment of biological activity. The 15N2 labeled diazirines are appealing motifs for hyperpolarization supporting relaxation protected states with long‐lived lifetimes. The (‐CH15N2) diazirine groups investigated here are analogues to methyl groups, which provides the opportunity to transfer polarization stored on a relaxation protected (‐CH15N2) moiety to 1H, thus combining the advantages of long lifetimes of 15N polarization with superior sensitivity of 1H detection. Despite the proximity of 1H to 15N nuclei in the diazirine moiety, 15N T1 times of up to (4.6±0.4) min and singlet lifetimes Ts of up to (17.5±3.8) min are observed. Furthermore, we found terminal diazirines to support hyperpolarized 1H2 singlet states in CH2 groups of chiral molecules. The singlet lifetime of 1H singlets is up to (9.2±1.8) min, thus exceeding 1H T1 relaxation time (at 8.45 T) by a factor of ≈100.
Cell‐Penetrating Dynamic‐Covalent Benzopolysulfane Networks
Authors: Cheng Yangyang , Zong Lili , López‐Andarias Javier , Bartolami Eline , Okamoto Yasunori , Ward Thomas R. , Sakai Naomi , Matile Stefan 
Published: June 2019

AbstractCyclic oligochalcogenides (COCs) are emerging as promising systems to penetrate cells. Clearly better than and different to the reported diselenolanes and epidithiodiketopiperazines, we introduce the benzopolysulfanes (BPS), which show efficient delivery, insensitivity to inhibitors of endocytosis, and compatibility with substrates as large as proteins. This high activity coincides with high reactivity, selectively toward thiols, exceeding exchange rates of disulfides under tension. The result is a dynamic‐covalent network of extreme sulfur species, including cyclic oligomers, from dimers to heptamers, with up to nineteen sulfurs in the ring. Selection from this unfolding adaptive network then yields the reactivities and selectivities needed to access new uptake pathways. Contrary to other COCs, BPS show high retention on thiol affinity columns. The identification of new modes of cell penetration is important because they promise new solutions to challenges in delivery and beyond.
Copper(I)‐Catalyzed Enantioconvergent Borylation of Racemic Benzyl Chlorides Enabled by Quadrant‐by‐Quadrant Structure Modification of Chiral Bisphosphine Ligands
Authors: Iwamoto Hiroaki , Endo Kohei , Ozawa Yu , Watanabe Yuta , Kubota Koji , Imamoto Tsuneo , Ito Hajime 
Published: June 2019

AbstractThe first copper(I)‐catalyzed enantioselective borylation of racemic benzyl chlorides has been realized by a quadrant‐by‐quadrant structure modulation of QuinoxP*‐type bisphosphine ligands. This reaction converts racemic mixtures of secondary benzyl chlorides into the corresponding chiral benzylboronates with high enantioselectivity (up to 92 % ee). The results of mechanistic studies suggest the formation of a benzylic radical intermediate. The results of DFT calculations indicate that the optimal bisphosphine‐copper(I) catalyst engages in noncovalent interactions that efficiently recognize the radical intermediate, and leads to high levels of enantioselectivity.
A Phthalocyanine‐Based Layered Two‐Dimensional Conjugated Metal–Organic Framework as a Highly Efficient Electrocatalyst for the Oxygen Reduction Reaction
Authors: Zhong Haixia , Ly Khoa Hoang , Wang Mingchao , Krupskaya Yulia , Han Xiaocang , Zhang Jichao , Zhang Jian , Kataev Vladislav , Büchner Bernd , Weidinger Inez M. , Kaskel Stefan , Liu Pan , Chen Mingwei , Dong Renhao , Feng Xinliang 
Published: June 2019

AbstractLayered two‐dimensional (2D) conjugated metal–organic frameworks (MOFs) represent a family of rising electrocatalysts for the oxygen reduction reaction (ORR), due to the controllable architectures, excellent electrical conductivity, and highly exposed well‐defined molecular active sites. Herein, we report a copper phthalocyanine based 2D conjugated MOF with square‐planar cobalt bis(dihydroxy) complexes (Co‐O4) as linkages (PcCu‐O8‐Co) and layer‐stacked structures prepared via solvothermal synthesis. PcCu‐O8‐Co 2D MOF mixed with carbon nanotubes exhibits excellent electrocatalytic ORR activity (E1/2=0.83 V vs. RHE, n=3.93, and jL=5.3 mA cm−2) in alkaline media, which is the record value among the reported intrinsic MOF electrocatalysts. Supported by in situ Raman spectro‐electrochemistry and theoretical modeling as well as contrast catalytic tests, we identified the cobalt nodes as ORR active sites. Furthermore, when employed as a cathode electrocatalyst for zinc–air batteries, PcCu‐O8‐Co delivers a maximum power density of 94 mW cm−2, outperforming the state‐of‐the‐art Pt/C electrocatalysts (78.3 mW cm−2).
Magnetic silk fibroin composite nanofibers for biomedical applications: Fabrication and evaluation of the chemical, thermal, mechanical, and in vitro biological properties
Authors: Lalegül‐Ülker Özge , Vurat Murat Taner , Elçin Ayşe Eser , Elçin Yaşar Murat 
Published: June 2019

ABSTRACTMagnetically responsive polymer composites have great potential for use in diverse biomedical applications. In this study, composite biomaterials consisting of silk fibroin (SF) and superparamagnetic iron oxide nanoparticles (SPIONs) were fabricated by the electrospinning method. Two different methods were employed to incorporate the SPIONs into the SF nanofibers. In the first encapsulation method (M1), SPIONs (1.0, 3.0, and 5.0 wt%) were initially included in the electrospinning solution. In the second dip‐coating method (M2), electrospun SF nanofiber mats were immersed in the aqueous suspensions of SPIONs (10, 30 and 50% v/v). Then, the pure and composite silk fibroin composite mats were comparatively evaluated for their morphological, chemical, magnetic, mechanical and in vitro biological properties, by using a number of methods including SEM, TEM, FTIR, XRD, EDS, VSM, TGA, mechanical tensile tests, as well as by indirect in vitro cytotoxicity and in vitro hemocompatibility analyses. Overall findings suggested that, while M1 nanofiber mats could be a suitable candidate for use in tissue engineering as a magnetically responsive cytocompatible scaffold, the M2 nanofiber mats perhaps could be more appropriate as an interface for triggering the in vitro stem cell differentiation and/or biosensor applications. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 48040.
Polyaniline nanofibers and porous Ni[OH]2sheets coated carbon fabric for high performance super capacitor
Authors: Uppugalla Susmitha , Srinivasan Palaniappan 
Published: June 2019

ABSTRACTIn this work, we used combination of two materials as a hybrid electrode material for supercapacitor. Ni(OH)2was coated on carbon fabric via electrochemical synthesis, and polyaniline salt was coated on Ni(OH)2‐coated carbon fabric viain situchemical oxidative polymerization of aniline in aqueous acidic medium (PNCF). For comparison, polyaniline salt was coated on bare carbon fabric (PCF) by same procedure. These fabrics were characterized by Raman, FE‐SEM, and EDAX and also were used as electrodes in symmetric supercapacitor cell. These cells were evaluated using cyclic voltammetry, charge–discharge and impedance spectral measurements. PNCF showed high energy density of 100 W h kg−1at a power density of 175 W kg−1and even at a high power density (875 W kg−1), it showed high energy density (74 W h kg−1). PNCF also showed 71% retention capacitance after 25 000 cycles at 1 A g−1. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci.2019,136, 48042.
A Bifunctional Luminescent Metal–Organic Framework for the Sensing of Paraquat and Fe3+ Ions in Water
Authors: Chen Hongjuan , Fan Peng , Tu Xingxin , Min Hui , Yu Xianyong , Li Xiaofang , Zeng Ju‐Lan , Zhang Shaowei , Cheng Peng 
Published: June 2019

AbstractThe hydrothermal reaction of Zn2+ ions with a mixture of two ligands, Hcptpy and H3btc (Hcptpy=4‐(4‐carboxyphenyl)‐2,2′:4′,4′′‐terpyridine; H3btc=1,3,5‐benzenetricarboxylic acid), led to the formation of a 3D metal–organic framework (MOF) with 1D channels, [Zn2(cptpy)(btc)(H2O)]n (1), which was structurally characterized by using single‐crystal X‐ray diffraction (SXRD). In MOF 1, two independent Zn2+ ions were interconnected by btc3− ligands to form a 1D chain, whilst adjacent Zn2+ ions were alternately bridged by cptpy− ligands to generate a 2D sheet, which was further linked by 1D chains to form a 3D framework with a new (3,3,4,4)‐connected topology. Furthermore, compound 1 also exhibited excellent stability towards air and water and, more importantly, luminescence experiments indicated that it could serve as a probe for the sensitive detection of paraquat (PAQ) and Fe3+ ions in aqueous solution.
Kinetic modeling as a tool to understand the influence of cell culture process parameters on the glycation of monoclonal antibody biotherapeutics
Authors: Agarwal Nitin , Mason Alison , Pradhan Rahul , Kemper Jan , Bosley Allen , Serfiotis‐Mitsa Dimitra , Wang Jihong , Lindo Viv , Ahuja Sanjeev , Hatton Diane , Savery James , Miro‐Quesada Guillermo 
Published: June 2019

AbstractGlycation, the nonenzymatic reaction between the reducing sugar glucose and the primary amine residues on amino acid side chains, commonly occurs in the cell culture supernatant during production of therapeutic monoclonal antibodies (mAbs). While glycation has the potential to impact efficacy and pharmacokinetic properties for mAbs, the most common undesirable impact of glycation is on the distribution of charged species, often a release specification for commercial processes. Existing empirical approaches are usually insufficient to rationalize the effects of cell line and process changes on glycation. To address this gap, we developed a kinetic model for estimating mAb glycation levels during the cell culture process. The rate constant for glycation, including temperature and pH dependence, was estimated by fitting the kinetic model to time‐course glycation data from bioreactors operated at different process settings that yielded a wide range of glycation values. The parameter values were further validated by independently estimating glycation rate constants using cell‐free incubation studies at various temperatures. The model was applied to another mAb, by re‐estimating the activation energy to account for effect of a glycation “hotspot”. The model was further utilized to study the role of temperature shift as an approach to reduce glycation levels in the manufacturing process for mAb2. While a downshift in temperature resulted in lowering of glycation levels for mAb2, the model helped elucidate that this effect was caused due to contribution from changes in glucose consumption, mAb secretion and temperature, instead of a direct impact of temperature alone on the kinetic rate of glycation.
Coronary‐subclavian steal syndrome, an easily overlooked entity in interventional cardiology
Authors: De Roeck Frederic , Tijskens Maxime , Segers Vincent F. M. 
Published: June 2019

AbstractCoronary‐subclavian steal syndrome (CSSS) is a severe complication of coronary artery bypass graft (CABG) surgery with internal mammary artery grafting. It is caused by functional graft failure due to a hemodynamically significant proximal subclavian artery stenosis. In this manuscript, we provide a comprehensive review of literature and we report a series of five consecutive CSSS cases. This case series illustrates the variable clinical presentation, thereby emphasizing the importance of raised awareness concerning this pathology in CABG patients.
Aerobic Self‐Esterification of Alcohols Assisted by Mesoporous Manganese and Cobalt Oxide
Authors: Moharreri Ehsan , Biswas Sourav , Deljoo Bahareh , Kriz David , Lim Seyoung , Elliott Sarah , Dissanayake Shanka , Dabaghian Marina , Aindow Mark , Suib Steven L. 
Published: June 2019

AbstractAerobic self‐esterification of primary alcohols catalyzed by mesoporous metal oxides (manganese and cobalt oxides) is reported under base and solvent free conditions. For a range of aliphatic alcohols, up to 90 % conversions to esters was achieved. The catalytic reaction is likewise applicable to neat aldehydes as substrates with yields of up to 86 %. High pressure batch reaction for ethanol to ethyl acetate led to 22 % yield. Isotope labeling studies indicated decarboxylation on the catalyst surface. Mechanistic and kinetic experiments implicate oxygen rebound and α‐carbon removal as intermediate steps. Mesoporous cobalt oxide showed about 20 % higher catalytic activity compared to mesoporous manganese oxide.
Palladium‐ and Ruthenium‐Catalyzed Intramolecular Carbene CAr−H Functionalization of γ‐Amino‐α‐diazoesters for the Synthesis of Tetrahydroquinolines
Authors: Solé Daniel , Amenta Arianna , Bennasar M.‐Lluïsa , Fernández Israel 
Published: June 2019

AbstractA synthetic method to prepare tetrahydroquinoline‐4‐carboxylic acid esters has been developed through the transition‐metal‐catalyzed intramolecular aromatic C−H functionalization of α‐diazoesters. Both [{Pd(IMes)(NQ)}2] (IMes=1,3‐dimesitylimidazol‐2‐ylidene, NQ=1,4‐naphthoquinone) and the first‐generation Grubbs catalyst proved effective for this purpose. The ruthenium catalyst was found to be the most versatile, although in a few cases the palladium complex afforded better yields or selectivities. According to DFT calculations, Pd0‐ and RuII‐catalyzed sp2‐CAr−H functionalization proceeds through different reaction mechanisms. Thus, the Pd0‐catalyzed reaction involves a Pd‐mediated 1,6‐H migration from the sp2‐CAr−H bond to the carbene carbon atom, followed by a reductive elimination process. In contrast, electrophilic addition of the ruthenacarbene intermediate to the aromatic ring and subsequent 1,2‐proton migration are operative in the Grubbs catalyst promoted reaction.