bluuebunny/crossref_metadata_2025_split huggingface dataset:
Testin protects against cardiac hypertrophy by targeting a calcineurin‐dependent signalling pathway
Authors: Gao Lu , Liu Yuan , Guo Sen , Xiao Lili , Liang Cui , Wang Xiaofang 
Published: November 2018

AbstractMultiple organs express testin (TES), including the heart. Nevertheless, current understanding of the influence of TES on cardiovascular diseases, especially on cardiac hypertrophy and its etiology, is insufficient. This study investigated the influence of TES on cardiac hypertrophy and its etiology. Murine models with excessive TES expression specific to the heart were constructed with an adeno‐associated virus expression system. Cardiac hypertrophy was stimulated through aortic banding (AB). The severity of cardiac hypertrophy was evaluated through molecular, echocardiographic, pathological, and hemodynamic examination. The findings of our study revealed that TES expression was remarkably suppressed not only in failing human hearts but also in mouse hearts with cardiac hypertrophy. It was discovered that excessive TES expression driven by an adeno‐associated viral vector noticeably inhibited hypertrophy triggered by angiotensin II (Ang II) in cultivated cardiomyocytes from newborn rats. It was also revealed that TES knockdown via AdshTES caused the reverse phenotype in cardiomyocytes. Furthermore, it was proved that excessive TES expression attenuated the ventricular dilation, cardiac hypertrophy, dysfunction, and fibrosis triggered by AB in mice. It was discovered that TES directly interacted with calcineurin and suppressed its downstream signalling pathway. Moreover, the inactivation of calcineurin with cyclosporin A greatly offset the exacerbated hypertrophic response triggered by AB in TES knockdown mice. Overall, the findings of our study suggest that TES serves as a crucial regulator of the hypertrophic reaction by hindering the calcineurin‐dependent pathway in the heart.
MiR‐15a/16‐1 deficiency induces IL‐10‐producing CD19+ TIM‐1+ cells in tumor microenvironment
Authors: Jia Xiaoqin , Liu Hao , Xu Chong , Han Sen , Shen Yating , Miao Xin , Hu Xiangyu , Lin Zhijie , Qian Li , Wang Zhengbing , Gong Weijuan 
Published: November 2018

AbstractIL‐10‐producing B cells (B10) are associated with autoimmune diseases, infection and tumours. MiR‐15a/16 as a tumour‐suppressive gene is down‐regulated in several tumours, such as chronic lymphocytic leukaemia, pituitary adenomas and prostate carcinoma. Here, increased frequency of IL‐10‐producing CD19+ Tim‐1+ cells was seen in both aged miR‐15a/16−/− mice (15‐18 months) with the onset of B cell leukaemia and young knockout mice (8‐12 weeks) transplanted with hepatic cancer cells. CD19+ Tim‐1+ cells down‐regulated the function of effector CD4+CD25low T cells ex vivo dependent on IL‐10 production, and adoptive transfer of CD19+ Tim‐1+ cells promoted tumour growth in mice. IL‐10 production by CD19+ Tim‐1+ cells was involved with the STAT3 activation. Bioinformatics analysis shows that miR‐16 targets the 3′‐untranslating region (3′‐UTR) of STAT3 mRNA. Overexpression of miR‐16 in CD19+ Tim‐1+ cells inhibited STAT3 transcription and its protein expression. Thus, the loss of miR‐15a/16 promoted induction of regulatory CD19+ Tim‐1+ cells in tumour microenvironment. These results confirmed that miR‐15a/16 could be used in tumour therapy due to its inhibition of tumour and regulatory B cells.
Evaluation of serum exosomal LncRNA‐based biomarker panel for diagnosis and recurrence prediction of bladder cancer
Authors: Zhang Shujun , Du Lutao , Wang Lishui , Jiang Xiumei , Zhan Yao , Li Juan , Yan Keqiang , Duan Weili , Zhao Yinghui , Wang Lili , Wang Yunshan , Shi Yuliang , Wang Chuanxin 
Published: November 2018

AbstractExosomes are small membrane vesicles released by many cells. These vesicles can mediate cellular communications by transmitting active molecules including long non‐coding RNAs (lncRNAs). In this study, our aim was to identify a panel of lncRNAs in serum exosomes for the diagnosis and recurrence prediction of bladder cancer (BC). The expressions of 11 candidate lncRNAs in exosome were investigated in training set (n = 200) and an independent validation set (n = 320) via quantitative real‐time PCR. A three‐lncRNA panel (PCAT‐1, UBC1 and SNHG16) was finally identified by multivariate logistic regression model to provide high diagnostic accuracy for BC with an area under the receiver‐operating characteristic curve (AUC) of 0.857 and 0.826 in training set and validation set, respectively, which was significantly higher than that of urine cytology. The corresponding AUCs of this panel for patients with Ta, T1 and T2‐T4 were 0.760, 0.827 and 0.878, respectively. In addition, Kaplan‐Meier analysis showed that non‐muscle‐invasive BC (NMIBC) patients with high UBC1 expression had significantly lower recurrence‐free survival (P = 0.01). Multivariate Cox analysis demonstrated that UBC1 was independently associated with tumour recurrence of NMIBC (P = 0.018). Our study suggested that lncRNAs in serum exosomes may serve as considerable diagnostic and prognostic biomarkers of BC.
Global distribution and invasion pattern of oriental fruit fly, Bactrocera dorsalis (Diptera: Tephritidae)
Authors: Zeng Yiying , Reddy Gadi V. P. , Li Zhihong , Qin Yujia , Wang Yannan , Pan Xubin , Jiang Fan , Gao Feng , Zhao Zi‐Hua 
Published: November 2018

AbstractSince the start of the 20th century, many invasive alien species (IAS) have spread rapidly around the world, causing serious threats to economies, societies and the environment. Bactrocera dorsalis (Hendel) (Diptera: Tephritidae) is an important quarantine insect species in many countries that spread around the world over the last century. This review collected information on the distribution of B. dorsalis to explore the patterns of its invasion expansion. We found B. dorsalis to be distributed in 75 countries (comprised of 124 geographical distribution regions: provinces or states) in Asia, Africa, North America, South America and Oceania up to 2017. Asia and Africa were the most represented regions, accounting for 86.3% of the total number of countries. From 1910 to 1990, B. dorsalis was only found in five countries, but in the last three decades, it has experienced a sharp increase in its rate of spread, invading 70 more countries. Global temperature anomaly has significantly positive correlation with the spread of B. dorsalis. The results of this review provide a theoretical basis for understanding and predicting the continued spread of B. dorsalis under global changes.
Retracted: Antibiotic resistance properties and genotypic characterization of enterotoxins in the Staphylococcus aureus strains isolated from traditional sweets
Authors: Mahmoodi Sadr Mohammadreza , Shakerian Amir , Rahimi Ebrahim , Momtaz Hasan 
Published: November 2018

AbstractResistant and enterotoxigenic Staphylococcus aureus are considered to be one of the major causes of foodborne diseases. The present investigation was done to study the pattern of antibiotic resistance and enterotoxigenic genes profile among the S. aureus strains isolated from traditional sweets. Two‐hundred sweet samples were cultured and S. aureus strains were identified. Antibiotic resistance and enterotoxigenic gene profile were studied using disk diffusion and polymerase chain reaction (PCR), respectively. Seventy‐nine out of 200 (39.50%) traditional sweet samples harbored S. aureus. Baghlava (79.16%) and Ghotab (73.10%) had the highest prevalence of S. aureus. S. aureus strains harbored the highest prevalence of resistance against penicillin (87.34%), tetracycline (84.81%), and erythromycin (65.82%). Distribution of sea, seb, sec, and sed were 5.06, 1.26, 8.86, and 1.26%, respectively. Presence of resistant and enterotoxigenic S. aureus showed an important public health issue. However, further researches are required to found additional epidemiological aspects of the bacteria.Practical applicationsDue to the high‐consumption rate of traditional sweet, they should have a high microbial quality. Staphylococcus aureus is common foodborne bacteria with an emergence of antibiotic resistance and enterotoxin production. This study emphasizes the importance of multidrug resistant enterotoxigenic Staphylococcus aureus in traditional sweet samples. Results represented that traditional sweet samples may act as a reservoir of S. aureus with ability to transfer antibiotic resistance and enterotoxin genes to human population.
Bacterial leakage and marginal adaptation of various bioceramics as apical plug in open apex model
Authors: Lertmalapong Patcharachol , Jantarat Jeeraphat , Srisatjaluk Ratchapin L. , Komoltri Chulaluk 
Published: November 2018

AbstractAimThe aim of the present study was to investigate bacterial leakage and marginal adaptation of bioceramic apical plugs.MethodsExtracted human mandibular premolars were prepared to simulate open apex using No. 4 Peeso reamer in retrograde direction. In total, 150 specimens were divided into 10 groups by obturation with five bioceramics in two thicknesses. Groups 1, 3, 5, 7, and 9 were obturated with ProRootMTA, Biodentine, TotalFill BC RRM paste, TotalFill BC RRM putty, and RetroMTA at 3 mm, and groups 2, 4, 6, 8, and 10 were obturated with the same materials at 4 mm. Ten specimens in each group were evaluated for bacterial leakage of Enterococcus faecalis for 75 days. Five specimens from each group were sectioned to investigate the gap area under scanning electron microscope.ResultsThe 3‐ and 4‐mm Biodentine and TotalFill BC RRM putty groups and the 4‐mm ProRootMTA group exhibited less bacterial leakage and lower mean percentage of gap area than those of the other groups. TotalFill BC RRM paste showed the highest leakage for both the 3‐ and 4‐mm groups.ConclusionThe 3‐ and 4‐mm Biodentine and TotalFill BC RRM putty groups and the 4‐mm ProRootMTA group exhibited the best sealing ability and marginal adaptation of apical plugs.
Social–emotional processing in nonverbal individuals with Angelman syndrome: evidence from brain responses to known and novel names
Authors: Key A. P. , Jones D. 
Published: November 2018

AbstractBackgroundThe combination of intellectual, communicative and motor deficits limits the use of standardised behavioural assessments in individuals with Angelman syndrome (AS). The current study aimed to objectively evaluate the extent of social–emotional processing in AS using auditory event‐related potentials (ERPs) during passive exposure to spoken stimuli.MethodsAuditory ERP responses were recorded in 13 nonverbal individuals with the deletion subtype of AS, age 4–45 years, during the name recognition paradigm, in which their own names and names of close others (relative or friend) were presented among novel names. No behavioural responses were required.ResultsContrary to findings in typical children and adults, there was no significant evidence of differential neural response to known vs. novel names in participants with AS. Nevertheless, greater amplitude differences between known and unknown names demonstrated the predicted association with better interpersonal relationships and receptive communication abilities.ConclusionsThese findings indicate good tolerability of ERP procedures (85% success rate). The lack of own name differentiation is consistent with increased incidence of the autism‐related symptoms in AS. Strong associations between the caregiver reports of adaptive functioning and neural indices of known name recognition support the utility of brain‐based measures for objectively evaluating cognitive and affective processes in nonverbal persons with neurodevelopmental disorders.
Interaction between PLA2R1 and HLA‐DQA1 variants contributes to the increased genetic susceptibility to membranous nephropathy in Western China
Authors: Wang Wei , Fan Shulei , Li Guisen , Wang Amanda Y , Hong Daqing , Zhong Xiang , Wang Li 
Published: November 2018

ABSTRACTAimRecent studies showed that single nucleotide polymorphisms (SNP) within the phospholipase A2 receptor (PLA2R1) and human leukocyte antigen complex class II HLA‐DQα‐chain 1 (HLA‐DQA1) genes were associated with the susceptibility to patients with primary membranous nephropathy (PMN). However, the results of previous research have not been always consistent.MethodsWe performed a case–control study including 314 patients with PMN and 354 healthy subjects in Western China. Eight SNP in PLA2R1 and one SNP in HLA ‐DQA1 were genotyped and association between PLA2R1 and HLA‐DQA1 was investigated. One hundred and twenty patients were detected anti‐PLA2R antibodies to analyze the association between genotype and anti‐PLA2R antibody.ResultsWe found A allele of rs2715918 (odds ratio (OR) = 1.66, corrected P values (Pc) = 7.9 × 10−3), A allele of rs4665143 (OR = 1.76, Pc = 2.7 × 10−6) and A allele of rs2187668 (OR = 3.29, Pc = 8.0 × 10−11) were associated with PMN. Susceptibility of PMN was significantly increased with rs2715918 in dominant model (OR = 1.624, Pc = 5.0 × 10−2), rs4665143 in recessive model (OR = 2.134, Pc = 1.4 × 10−4) and rs2187668 in dominant model (OR = 3.961, Pc = 4.1 × 10−11). The haplotype ATAC of rs2715918, rs6757188, rs4665143, rs3749119 was associated with the high risk of PMN (OR = 1.453, P = 3.0 × 10−4). Interaction of rs2715918 GA/AA, rs4665143 GA/AA and rs2187668 GA/AA could significantly increase the 10.61‐fold higher risk for the development of PMN (OR = 10.61, P = 4.0 × 10−10). Patients who carried with risk genotypes for both HLA‐DQA1 and PLA2R1 (87.8%) had antibodies positivity. However, patients who carried low‐risk genotypes (41.6%) had antibodies positivity (P = 0.001).ConclusionThere are some differences in PLA2R1 distributions in PMN patients between previous literature and our study. Our results showed that interactions between PLA2R1 and HLA‐DQA1 alleles increased genetic susceptibility to PMN in Western China.
On the Real Effect of Financial Pressure: Evidence From Firm‐Level Employment During the Euro‐Area Crisis
Authors: Fernandes Filipa Da Silva , Kontonikas Alexandros , Tsoukas Serafeim 
Published: November 2018

AbstractUsing a large panel of mainly unquoted euro‐area firms over the period 2003–2011, this paper examines the impact of financial pressure on firms’ employment. The analysis finds evidence that financial pressure negatively affects firms’ employment decisions. This effect is stronger during the euro area‐crisis (2010–2011), especially for firms in the periphery compared to their counterparts in non‐periphery European economies. When we introduce firm‐level heterogeneity, we show that financial pressure appears to be both statistically and quantitatively more important for bank‐dependent, small and privately held firms operating in periphery economies during the crisis.
The role of mindfulness in physical activity: a systematic review
Authors: Schneider J. , Malinowski P. , Watson P. M. , Lattimore P. 
Published: November 2018

SummaryDespite continued public health campaigns to promote physical activity, a majority of the population is inactive. In recent years, mindfulness‐based approaches have been used in health and lifestyle interventions for physical activity promotion. We conducted a systematic literature review using the Preferred Reporting Items for Systematic Reviews and Meta‐Analyses guidelines to investigate the evidence for the potential of mindfulness‐based approaches for physical activity. We searched electronic databases for papers that met eligibility criteria and identified 40 studies for inclusion. Evidence from cross‐sectional studies (n = 20) indicated a positive relationship between dispositional mindfulness and physical activity, particularly with psychological factors related to physical activity. Five studies found that the mindfulness–physical activity relationship was mediated by stress, psychological flexibility, negative affect and shame, satisfaction and state mindfulness. Evidence from mindfulness‐based interventions (n = 20) suggested positive between‐subjects effects on physical activity, but interventions varied in duration, session length, group size, delivery, content and follow‐up. Mindfulness‐based interventions were more likely to be successful if they were physical activity‐specific and targeted psychological factors related to physical activity. The body of research shows a need for more methodologically rigorous studies to establish the effect of mindfulness on physical activity and to identify potential mechanisms involved in the mindfulness–physical activity relationship reliably.
Brief tools to measure obesity‐related behaviours in children under 5 years of age: A systematic review
Authors: Byrne Rebecca , Bell Lucy , Taylor Rachael W. , Mauch Chelsea , Mihrshahi Seema , Zarnowiecki Dorota , Hesketh Kylie D. , Wen Li Ming , Trost Stewart G. , Golley Rebecca 
Published: November 2018

SummaryIntroductionValid and reliable tools for measuring obesity‐related behaviours in young children that are brief and can be administered quickly and cost‐effectively in large‐scale population studies are needed. The objectives of this systematic review were to describe brief tools that measure dietary intake, physical activity, sedentary behaviour, and sleep in young children.MethodsA systematic review of studies published in English in six databases (CINAHL, Medline, Embase, PsycINFO, HaPI, and Cochrane) prior to April 2018 was undertaken using the PROSPERO protocol and PRISMA guidelines. Included studies were those reporting the psychometric properties of brief (≤15 items) tools that measure dietary, activity, or sleep‐related behaviours, alone or in combination, in children birth to 4.9 years of age.ResultsThe search identified 11 379 papers, 200 full‐text articles were screened for eligibility, and 12 met the inclusion criteria. Three studies measured two behavioural domains, while most assessed a single behaviour (three diet, five physical activity, one sleep, and none sedentary behaviour). Only two (one diet, one sleep) focused on the under 2 age group. Few studies assessed reliability, and validity and findings were mixed.ConclusionsThere is a need to develop brief tools to measure early life obesity‐related behaviours, particularly those assessing sedentary behaviour and sleep and tools that cover multiple domains.
Novel loci and a role for nitric oxide for seed dormancy and preharvest sprouting in barley
Authors: Nagel Manuela , Alqudah Ahmad M. , Bailly Marlène , Rajjou Loïc , Pistrick Sibylle , Matzig Gabriele , Börner Andreas , Kranner Ilse 
Published: November 2018

AbstractBarley is used for food and feed, and brewing. Nondormant seeds are required for malting, but the lack of dormancy can lead to preharvest sprouting (PHS), which is also undesired. Here, we report several new loci that modulate barley seed dormancy and PHS. Using genome‐wide association mapping of 184 spring barley genotypes, we identified four new, highly significant associations on chromosomes 1H, 3H, and 5H previously not associated with barley seed dormancy or PHS. A total of 71 responsible genes were found mostly related to flowering time and hormone signalling. A homolog of the well‐known Arabidopsis Delay of Germination 1 (DOG1) gene was annotated on the barley chromosome 3H. Unexpectedly, DOG1 appears to play only a minor role in barley seed dormancy. However, the gibberellin oxidase gene HvGA20ox1 contributed to dormancy alleviation, and another seven important loci changed significantly during after‐ripening. Furthermore, nitric oxide release correlated negatively with dormancy and shared 27 associations. Origin and growth environment affected seed dormancy and PHS more than did agronomic traits. Days to anthesis and maturity were shorter when seeds were produced under drier conditions, seeds were less dormant, and PHS increased, with a heritability of 0.57–0.80. The results are expected to be useful for crop improvement.
Using the Omaha System to determine health problems of urban Syrian immigrants
Authors: Ardic Aysun , Esin Melek Nihal , Koc Serife , Bayraktar Bilgenur , Sunal Nihal 
Published: November 2018

AbstractObjective(s)This study assessed the health problems of Syrian immigrants living in urban areas using the Omaha System.DesignA descriptive and observational study was conducted in Istanbul.SampleThe sample included 51 Syrian immigrant families and 248 Syrian refugees.MeasuresData were collected using the Omaha System‐Problem Classification List and a sociodemographic questionnaire.ResultsThe average household size was 6.36; 71% of those over the age of 18 were not employed. Only 8.5% of children aged 0–15 were vaccinated; 15 nursing problems and 46 signs and symptoms were diagnosed using the Problem Classification List scale. Personal care was the most frequently diagnosed problem, followed by Sanitation, Communication with community resources, Mental health, and Residence.ConclusionsHealth and social problems are common Syrian immigrants living in urban areas. The Omaha System‐Problem Classification List can be used as a tool by public health nurses to identify health problems encountered by immigrants.
Prevalence and correlates of depression among older urban community‐dwelling adults in Sri Lanka
Authors: Rajapakshe Onali B.W. , Sivayogan Sivagurunadan , Kulatunga Prasadi M. 
Published: November 2018

AimAs the population ages, mental health issues among the elderly are becoming a major concern worldwide, including in Sri Lanka. With rapid globalization, the coping and adapting skills of elderly individuals are tested, potentially revealing predisposition to psychological disturbances. Previous studies have indicated a higher risk of depression among the elderly. The current study attempts to quantify the prevalence and associated factors of depression in a highly urbanized setting within Sri Lanka.MethodsA community‐based, cross‐sectional analytical study was carried out in the urban areas of Colombo District. The subjects were young elders (60–74 years) who permanently reside in the area. Depression was assessed by the item Geriatric Depression Scale Sinhalese version (cut‐off score ≥8) among 1283 subjects. Logistic regression analysis was used to assess the association of depression with sociodemographic and health‐related variables.ResultsThe prevalence of depression in the sample was 13.9% (mild depression: 11.2%; moderate to severe depression: 2.7%). Among the sociodemographic predictors, female sex (odds ratio (OR) = 10.60), being 60–64 years old (OR = 1.61), being unmarried, separated, divorced, or widowed (OR = 3.73), income ≤20 000 Sri Lankan rupees (OR = 2.27), and perceived financial burden (OR = 3.15) were significantly associated with clinically significant depression. Among the health‐related variables, smoking (OR = 2.18), alcohol use (OR = 7.58), presence of chronic disease (OR = 1.51), limitation in performing one or more instrumental activities of daily living (OR = 1.73), unsatisfactory partner relationship (OR = 2.94), perceived inadequate social support (OR = 2.47), experiencing abuse (OR = 3.90), and experiencing major life events (OR = 2.11) were significantly related with depression.ConclusionDepression is an important issue among the elderly living in an urbanized environment in Sri Lanka.
Non‐invasive ventilation: Essential requirements and clinical skills for successful practice
Authors: Elliott Mark W. 
Published: November 2018

ABSTRACTAudits and case reviews of the acute delivery of non‐invasive ventilation (NIV) have shown that the results achieved in real life often fall short of those achieved in research trials. Factors include inappropriate selection of patients for NIV and failure to apply NIV correctly. This highlights the need for proper training of all involved individuals. This article addresses the different skills needed in a team to provide an effective NIV service. Some detail is given in each of the key areas but it is not comprehensive and should stimulate further learning (reading, attendance on courses, e‐learning, etc.), determined by the needs of the individual.