bluuebunny/crossref_metadata_2025_split huggingface dataset:
Magnesium-dependent Phosphatase (MDP) 1 is a Potential Suppressor of Gastric Cancer
Authors: Zhu Jianbo , Deng Lijuan , Chen Baozhen , Huang Wenqing , Lin Xiandong , Chen Gang , Tzeng Chi-Meng , Ying Mingang , Lu Zhongxian 
Published: June 2019

Background:Recurrence is the leading cause of treatment failure and death in patients with gastric cancer (GC). However, the mechanism underlying GC recurrence remains unclear, and prognostic markers are still lacking.Methods:We analyzed DNA methylation profiles in gastric cancer cases with shorter survival (<1 year) or longer survival (> 3 years), and identified candidate genes associated with GC recurrence. Then, the biological effects of these genes on gastric cancer were studied.Results:A novel gene, magnesium-dependent phosphatase 1 (mdp1), was identified as a candidate gene whose DNA methylation was higher in GC samples from patients with shorter survival and lower in patients with longer survival. MDP1 protein was highly expressed in GC tissues with longer survival time, and also had a tendency to be expressed in highly differentiated GC samples. Forced expression of MDP1 in GC cell line BGC-823 inhibited cell proliferation, whereas the knockdown of MDP1 protein promoted cell growth. Overexpression of MDP1 in BGC-823 cells also enhanced cell senescence and apoptosis. Cytoplasmic kinase protein c-Jun N-terminal kinase (JNK) and signal transducer and activator of transcription 3 (Stat3) were found to mediate the biological function of MDP1.Conclusion:These results suggest that MDP1 protein suppresses the survival of gastric cancer cells and loss of MDP expression may benefit the recurrence of gastric cancer.
High-accuracy Automated Diagnosis of Parkinson's Disease
Authors: Ozsahin Ilker , Sekeroglu Boran , Pwavodi Pwadubashiyi Coston , Mok Greta S.P. 
Published: June 2019

Purpose:
Parkinson's disease (PD), which is the second most common neurodegenerative
disease following Alzheimer’s disease, can be diagnosed clinically when about 70% of the dopaminergic
neurons are lost and symptoms are noticed. Neuroimaging methods such as single photon
emission computed tomography have become useful tools in vivo to assess dopamine transporters
(DATs) in the striatal region. However, inter- and intra-reader variability of construing the images
might result in misdiagnosis. To overcome the challenges posed by classification of the disease,
image preparation techniques and a back propagation neural network (BPNN) have been proposed.
The aim of this study is to show that the proposed method can be used for the classification of PD
with high accuracy.

Methods:
In this study, we used basic image preparation techniques and a BPNN on DAT imaging
datasets from the Parkinson’s Progression Markers Initiative. 1,334 PD and 212 normal control
(NC) subjects were included. In the image preparation phase, adaptive histogram equalization was
applied to the cropped images, followed by image binarization. Then, the mass-difference method
was applied to separate the regions of interest with similar values. Finally, the binarized images
were subtracted from the original images, and the average pixel per node approach was applied to
the images to minimize the inputs. In the BPNN phase, 400 input neurons and 2 output neurons
were used. The dataset was divided into three sets: training, validation, and test. The BPNN was
trained several times in order to obtain the optimum values.

Results:
The use of 40 hidden neurons, a learning rate of 0.00079, and a momentum factor of 0.90
produced superior results and were applied in the final BPNN architecture. The tolerance value
used was 0.80. Uniquely, we found the sensitivity, specificity, and accuracy for PD vs. NC classification
to be 99.7%, 99.2%, 99.6%, respectively. To the best of our knowledge, this is the highest
accuracy value achieved in the existing literature. Our method increases computational speed together
with improved performance.

Conclusion:
We have shown that effective image processing methods and the use of BPNN can
successfully be applied to PD datasets to accurately determine any abnormalities in DATs. Using
the shallow neural network, this procedure requires less processing time compared to other methods,
and its accuracy, sensitivity, and specificity are reliable. However, further studies are needed
to establish a prediction method for the preclinical and prodromal stages of the disease.
Температурная активация электронов проводимости в двойной квантовой яме HgTe/CdHgTe p-типа проводимости со слоями HgTe критической толщины
Authors: Подгорных С.М. , Якунин М.В. , Криштопенко С.С. , Попов М.Р. , Михайлов Н.Н. , Дворецкий С.А. 
Published: June 2019

AbstractThe temperature dependences of the Hall coefficient and magnetoresistivity of a p -type HgTe/CdHgTe double quantum well with HgTe layers of critical thickness in the temperature range T = 35–300 K under magnetic fields up to 9 T are investigated. The position of the earlier observed reentrant quantum Hall transition from plateau i = 1 to plateau i = 2 is found to be close to the transition field from light to heavy holes with an increase in the magnetic field in the classical Hall effect. It is found that thermally activated light electrons contribute to the Hall effect along with light and heavy holes at T ≥ 35 K. The activation energy of electrons is estimated from the temperature dependence of the electron concentration as 28 meV, which exceeds the calculated value from the lateral maximum of the valence subband to the edge of the lowest conduction subband, probably because of heterostructure asymmetry.
Формирование нанокристаллов в аморфной фазе многокомпонентных систем
Authors: Абросимова Г.Е. , Аронин А.С. , Волков Н.А. 
Published: June 2019

AbstractThe effect of the concentration of alloying components on the crystallization of amorphous (Fe_73Si_13B_9)_1 – _ x _– _ y Nb_ x Cu_ y and (Co_70Si_12B_9)_1 – _ x _– _ y Fe_ x Nb_ y alloys has been studied by X-ray diffraction and transmission electron microscopy in a wide composition region. The formation of the bcc structures in both the alloy groups is shown to be substantially dependent on the alloying component concentrations. The bcc phase is found to form in the cobalt-based alloys in the concentration region, where it was not observed before. In the cobalt-based alloys, the bcc phase appears at a niobium concentration higher than 1 at % and the average bcc nanocrystal size varies from 40 nm (at 1 at % Nb) to 14 nm (at 5 at % Nb). In the Fe-based alloys, nanocrystals with the bcc lattice form at the copper concentrations of 0.45–1 at %, and the average nanocrystal size is dependent on the alloy composition and varies in the range 16–24 nm. The causes of the concentration dependence of the formation of nanostructures in these alloys are discussed.
Progressive Decline in Estimated Glomerular Filtration Rate in Patients With Diabetes After Moderate Loss in Kidney Function—Even Without Albuminuria
Authors: Vistisen Dorte , Andersen Gregers Stig , Hulman Adam , Persson Frederik , Rossing Peter , Jørgensen Marit Eika 
Published: June 2019

OBJECTIVE
Persons with diabetes but no chronic kidney disease (CKD) and without albuminuria have the same age-related decline in kidney function as the background population. Whether this also applies following moderate loss in kidney function is unknown. We quantified the impact of albuminuria status on the development of estimated glomerular filtration rate (eGFR) trajectories following CKD stage 3 (CKD3) and assessed potential heterogeneous development patterns among the subgroup with normoalbuminuria.

RESEARCH DESIGN AND METHODS
We used repeated clinical measures during up to 16 years of follow-up in 935 persons with type 1 diabetes and 1,984 with type 2 diabetes. Trajectories of eGFR by diabetes type and albuminuria status following CKD3 were estimated with spline mixed-effects models with adjustment for relevant confounders. Latent class trajectory modeling was used to find distinct patterns of eGFR development in the subgroups with normoalbuminuria.

RESULTS
Mean annual declines in eGFR for normo-, micro- and macroalbuminuria the first 10 years following CKD3 were 1.9, 2.3, and 3.3 mL/min/1.73 m2 in type 1 diabetes and 1.9, 2.1, and 3.0 in type 2 diabetes, respectively. For normoalbuminuria, two distinct eGFR patterns were found, one with accelerated declining eGFR levels. This specific progression pattern was associated with less use of lipid-lowering treatment, renin-angiotensin system blockers, and other antihypertensive treatment.

CONCLUSIONS
Our results support a diabetes-dependent decline in kidney function without albuminuria following CKD3, with a subgroup showing a progressive decline. Furthermore, this group seems to be undertreated in terms of cardioprotective and renal protective treatment and suggests that increased attention should be drawn to normoalbuminuric diabetic kidney disease.
Disturbed Eating Behaviors in Adolescents and Emerging Adults With Type 1 Diabetes: A One-Year Prospective Study
Authors: Luyckx Koen , Verschueren Margaux , Palmeroni Nina , Goethals Eveline R. , Weets Ilse , Claes Laurence 
Published: June 2019

OBJECTIVE
Disturbed eating behavior (DEB) is prevalent in youth with type 1 diabetes and is accompanied by an increased risk for complications, morbidity, and mortality. Prospective studies on DEB in the challenging transition to adulthood are scarce. This longitudinal study examined DEB over a 1-year period and investigated the directionality of effects linking DEB to diabetes-specific functioning and depressive symptoms in adolescents and emerging adults.

RESEARCH DESIGN AND METHODS
Three hundred youth (16–28 years old) with type 1 diabetes participated in a two-wave longitudinal study. Questionnaires measured DEB (Diabetes Eating Problem Survey-Revised [DEPS-R]), self-management, diabetes distress, and depressive symptoms. HbA1c values were obtained from physicians. Mixed ANOVA and cross-lagged analysis were used to examine prospective changes and directionality of effects, respectively.

RESULTS
Mean DEB remained stable in the total sample, but significant individual differences were observed based on the cutoff score of the DEPS-R: 19% displayed persistent DEB and 8% increased and 7.3% decreased in DEB over time. The remaining individuals scored low on DEB over time. These four groups were differentiated based on insulin restriction, omission, diabetes-specific functioning, and depressive symptoms. Cross-lagged analyses indicated that DEB predicted relative increases in depressive symptoms over time, whereas reciprocal associations with glycemic control were found.

CONCLUSIONS
This longitudinal study highlights the substantial impact DEB may have in the transition to adulthood, with a substantial portion of youth with type 1 diabetes being at risk for clinical DEB. Prospective pathways linking DEB to functioning were found, emphasizing the clinical relevance of assessing DEB over time.
PENINGKATAN HASIL BELAJAR IPS MELALUI PENGGUNAAN MEDIA GAMBAR PADA SISWA KELAS III SDN 50 BULU DATU PALOPO
Authors: Dahlia Dahlia 
Published: June 2019

The main problem in this study is the low learning outcomes of social studies for III grade students of SDN 50 Bulu Datu Palopo . There is also the problem formulation, that is : can the purpose of this study is that student learning outcomes can be improved by using picture media in class III SDN 50 Bulu DATU Palopo on subject IPS. held three times, with the planning stage act of observation and reflection. The subject of this research is class students III SDN 50 Bulu Datu Palopoin odd semester of school year 2018/2019 with a total of 23 students . The results of the show that : with the use of media images off class IIIÂ SDN 50 Bulu Datu Palopo students learning outcomes conducted in two cycles shows that student learning outcomes have increased,from the cycle I average value 72 with percentage of completeness 65%, while cycle II average value 92 with percentage of complete 100% and has fulfilled the value KKM that is 70.
Retrospective liver histomorphological analysis in dogs in instances of clinical suspicion of congenital portosystemic shunt
Authors: Sobczak-Filipiak Małgorzata , Szarek Józef , Badurek Iwona , Padmanabhan Jessica , Trębacz Piotr , Januchta-Kurmin Monika , Galanty Marek 
Published: June 2019

Abstract

Introduction: The clinical symptoms of portosystemic shunts (PSSs) and hepatic microvascular dysplasia (HMD) – portal vein hypoplasia (PVH) in dogs are similar. PSSs are abnormal vascular connections between the portal vein system and systemic veins. HMD is a very rare developmental vascular anomaly, recognisable during histopathological examination. The study aim was to assess the prevalence of HMD–PVH and hepatocellular and vascular pathologies in the liver. Material and Methods: Liver biopsies from 140 dogs (of different breeds and both sexes) arousing clinical suspicion of PSS were examined histopathologically. Results: An initial PSS diagnosis was confirmed in 125 dogs (89.29%). HMD–PVH was found in 12.32% of dogs, as an isolated disease in 9.29%, especially in Yorkshire terriers, and with extrahepatic PSS in 6.67%. Histopathological analysis of muscles around sublobular veins showed that HMD cases presented hypertrophy or hypertrophy with fibrosis. In 2.17% of all dogs with liver vascular developmental disorders calcification was visible around vessels (without correlation by degenerative changes in those vessels), suggesting prior onset of deep metabolic disorders. Clinical suspicion of PSS was also formed upon quite different pathological processes in young dogs. Conclusion: Histopathological findings diagnosed the type of vascular anomalies (PSS or HMD–PVH) or other pathological changes conclusively, therefore detailed hepatic histopathology is an indispensable component of the clinical diagnostic process.
ANALISIS PENERAPAN BENTUK-BENTUK TINDAK PIDANA PEMILU
Authors: Mulyadi Dudung 
Published: June 2019

Tindak Pidana Pemilu dapat dimasukkan dalam pidana khusus yaitu pidana pemilu dan pelanggaran baik diatur dalam Kitab Undang-Undang Hukum Pidana (KUHP) dan diatur dalam Undang-Undang Republik Indonesia Nomor 7 Tahun 2017 tentang Pemilihan Umum. Adapun para pihak yang dapat disangkakan terhadap tindak pemilu adalah: a) Penyelengara Pemilu (KPU, Bawaslu, Pemerintah); b) Peserta Pemilihan Umum (Partai Politik, Calon DPR, DPD, DPRD, Calon Presiden dan Wakil Presiden); c) Masyarakat sebagai subjek hukum (sebagai pemilih, Tim Sukses termasuk Masyarakat yang mengajak tidak menggunakan hak suaranya).
Ortaokul öğrencilerinin Türkçe dersinde kullandıkları eleştirel dinleme stratejilerinin çeşitli değişkenler yönünden incelenmesi
Authors: FİDAN Mehmet 
Published: June 2019

Dinleme eğitimi çok boyutlu yapısı ile
eğitim-öğretim süreçlerinde önemli konumda bulunur. Dinleme eğitimi
süreçlerinde öğrencilerin kullandıkları stratejilerinden olan eleştirel dinleme
öğrencinin akademik gelişimini olumlu yönde şekillendirmektedir. Bu sebeple
öğrencilerin derslerde kullandıkları eleştirel dinleme stratejilerinin
belirlenmesi gerekmektedir. Bu araştırmada, ortaokul öğrencilerinin Türkçe derslerinde kullandıkları eleştirel dinleme
stratejilerinin değerlendirilmesi yapılmıştır. Araştırma
sürecinde nicel araştırma yöntemlerinden tarama modeli kullanılmıştır. Öğrencilerin Türkçe derslerinde kullandıkları eleştirel dinleme
stratejileri cinsiyet, sınıf düzeyi ve sosyo-ekonomik düzey yönünden
karşılaştırmalı olarak incelenmiştir. Ayrıca öğrencilerin
eleştirel dinleme stratejilerini kullanım oranları belirlenmeye çalışılmıştır. Araştırmanın çalışma evreni Kayseri ili Melikgazi, Talas
ve Kocasinan ilçelerindeki ortaokul öğrencilerinden oluşmuştur. Araştırmanın örneklemi bu öğrenciler arasından random örnekleme yöntemi ile seçilen öğrencilerden oluşmaktadır. Araştırmada
F testi (tek yönlü varyans analizi), derecelendirme analizi (yüzde, frekans) ve
t - testi kullanılmıştır. Araştırma
sonucunda maddelerin genel ortalamasına bakıldığında, öğrencilerin eleştirel dinleme stratejilerini kullanımlarının
cinsiyet, sınıf düzeyi, sosyo-ekonomik düzey yönünden bazı maddelerde
farklılaştığı görülmüştür. Öğrencilerin genel olarak
eleştirel dinleme stratejilerini kullandıkları sonucuna ulaşılmıştır. Bu duruma
ek olarak, öğrencilerin Türkçe derslerinde dinlediklerini önem sırasına koyma
stratejisini diğer eleştirel dinleme stratejilere göre daha az kullandıkları
tespit edilmiştir.&nbsp;
Attitude and practice regarding effective blood pressure measurement among health professionals at a tertiary care hospital in Hyderabad - Pakistan
Authors: Zaman Rabail , Anam Sobia , Muhammad Muneeb  , Ashraff Sabry 
Published: June 2019

Background: Blood pressure (BP) measurement is one of the basic indicator used for the diagnosis, treatment and research investigations of Hypertension. The accuracy of the measurements have the potential to influence the decision making and therefore is a prerequisite, regardless of which technique is used. Still, too often the accuracy of measurement is taken for granted in general practice. This study aims to gauge the attitude and practice of health professionals regarding effective BP measurement at a tertiary care hospital.
Methodology: This cross-sectional study comprised of 50 healthcare professionals, chosen via purposive sampling from Liaquat University Hospital, a tertiary care hospital at Jamshoro, Hyderabad during November, 2015 to January, 2016. A self-administered structured qualitative and quantitative questionnaire was used to evaluate the attitude and practice of effective BP measurement. The data was analyzed through SPSS version 19 and Microsoft Excel.
Results: According to the study results, 88% of the participants had clinical experience of up to 5 years. Around 56% of the respondents rated their BP measurement skills as very good, 38% as good while 6% as acceptable. It was found that 46% of the respondents use to measure BP only once whereas 54% do it twice to get a mean value. For the location of measuring the BP, 60% responded to use only one arm while, 40% reported to measure it from both arms. Furthermore, many of the respondents reported for never attending any Continuous Medical Education (CME) regarding BP measurement along with the 48%, who declared that they had never updated their knowledge regarding BP measurement guidelines.
Conclusion: It is evident from the survey that selected set of healthcare professionals had lesser focus toward accurate methods of BP measurement as well as low interest in updating their knowledge regarding the standard protocols. It is concluded that up gradation of knowledge and awareness reading standard and current practices must be taught regularly and must be mandatory to follow for all healthcare providers.
“Kang Pisang”: Personal Branding of the Jokowi’s Youngest Son in the Microblogging Media
Authors: Narida Marshelia Gloria 
Published: June 2019

Awareness in using the technology for building a self brand through personal branding can appear in anyone, whether from the public figures, nor from the society in general. The youngest son of Presiden Joko Widodo (Jokowi), Kae Sang Pangareb (Kae Sang) is known as an person who has a high level of awareness on her social media. This study examines trends in shaping the content of microblogging as a personal branding of Kae Sang. Studies conducted on the accounts twitter Kae Sang (@kaesangp) by looking at twitter account contents and personal branding process through microblogging. According to personal brand buildings theory by Peter Montoya, this research take 8 personal brand building category, specialization, leadership, personality, distinctiveness, visibility, unity, persistence, and good will. It can be conveyed that the personal branding of Kae Sang on twitter complies with the criteria of the forming of personal brandingKeyword : Personal Branding; Microblogging; Twitter
Economic characteristics of pig breeding in Russia
Authors: Kostenko O. V. 
Published: June 2019

The article presents the results of analytical studies of the main economic characteristics of pig production in Russia. Theoretical and methodological basis was developed according to the works on the theory of strategic management. The information base for the study was formed upon the data from the Federal State Statistics Service of Russia, National Union of Swine Breeders, AFK Group of Companies (St. Petersburg), expert-analytical center of agribusiness (Maykop), annual reports of the largest Russian agricultural holdings. On the whole, the industry is attractive in terms of opportunities for development and viability of investment. Annual production volumes are 3.5 million tons of pork in slaughter weight, or about 300-400 billion rubles. The market is growing at a rate of at least 5% per year, but growth rates are slowing. The industry is highly consolidated; 20 large vertically integrated holdings provide 62% of output. Pig products are standardized and intended for further processing; price competition prevails in the markets. Self-sufficiency in domestic products has exceeded 90% in recent years. The share of import has significantly decreased. The industry is characterized by high capital intensity; the cost of investment projects is estimated in the billions of rubles. Innovative development of pig production in Russia has been adopting imported technologies and developments. The level of dependence on imported machinery and equipment, breeding materials, feed additives and veterinary drugs is critical. The industry is attractive upon profitability criterion (industry profitability rate is above the average for the economy).
Competitive complex of machinery and technologies for the production of grain and feed
Authors: Mazitov N. K. , Sakhapov R. L. , Shogenov Yu. Kh. , Sharafiev L. Z. , Tsench Yu. S. , Rakhimov I. R. 
Published: June 2019

The current situation in agricultural production is challenging. During the last 2 decades, the agrarian production system has been deteriorating. It concerns crop rotations, moisture accumulation and moisture conservation technologies, ways of increasing soil fertility and growing environmentally friendly grain, reducing production costs and increasing product profitability. But there are forced late sowings and artificial “drought”. All this provides reasons to consider domestic breeding and seed production obsolete and to introduce the foreign analogue, which has planned negative impacts not only on quantitative, but also on qualitative safety. The article provides the solution to this major strategic problem. Under the research program of the Russian Academy of Agricultural Sciences, a highly competitive technology for the production of grain and fodder was developed on the basis of only domestic equipment that 2-5 times predominates over the best foreign analogues in functional indicators. It was confirmed by a number of state tests in 1990-2016 and approved by numerous meetings of the Scientific and Technical Council of the Ministry of Agriculture of the Russian Federation, RAS. The units of domestic tractors and functional machines that can compete with the best foreign counterparts have been developed.