bluuebunny/crossref_metadata_2025_split huggingface dataset:
Standards of care for peripheral intravenous catheters: evidence-based expert consensus
Authors: Thompson Judy , Steinheiser Marlene M , Hotchkiss J Blake , Davis James , DeVries Michelle , Frate Katie , Helm Robert , Jungkans Chris W. , Kakani Swapna , Lau Sean , Lindell Karen , Landrum Kristen McNiff , McQuillan Karen A , Shannon DJ , Wuerz Lorelle , Pitts Stephanie 
Published: November 2024

Background: The insertion of a PIVC is the most commonly performed invasive procedure in healthcare. Despite its frequency in placement in hospitalized patients, PIVCs are generally perceived as being safe; however, the prevalence of failure ranges from 35%-50%. Additionally, complications are common and often deemed ‘acceptable’ by clinicians. Healthcare provider and clinician foundational knowledge and competency is lacking nationally. Considering the mere volume of PIVCs placed, the failure and complication rates, the human impact is significant. Methods: The Association for Vascular Access (AVA) has led a collaborative effort with representatives from the Infusion Nurses Society (INS), the American Association of Critical Care Nurses (AACN), ECRI, and content experts representing nursing vascular access, infusion therapy, infection prevention, critical care, pediatrics, healthcare leadership, a physician, and a patient representative. Our aim is to provide concise guidance that will enhance and standardize practices related to PIVC. By consolidating current standards of practice into a comprehensive document, our framework seeks to advance the quality of care and improve patient safety. Results: This document has undergone meticulous scrutiny to ensure its quality, including incorporation of current standards, methodology for consensus from the expert panel, and input received from public comments. Conclusions: We anticipate that this work will have a significant impact on healthcare professionals, policymakers, and, most importantly, patients’ experiences by the promotion of consistent, high-quality treatment, safety, and comfort for patients receiving a PIVC.
A Rare Complication of Atraumatic Splenic Rupture in Infectious Mononucleosis: A Case Report
Authors: Gavriilidis Paschalis , Xanthakos Pantelis 
Published: November 2024

Aims/Background Atraumatic splenic rupture is a very rare and potentially life-threatening event usually associated with underlying pathological conditions. Splenic rupture in infectious mononucleosis occurs only in 0.1%–0.5% of patients. The aim of the present study was to publish a case report of the atraumatic splenic rupture and to present a mini-review of the international literature. Case Presentation A 30-year-old man of mixed races (Caucasian and African) diagnosed with acute cholecystitis was referred by a rural doctor to a secondary district hospital. His past medical and family history was unremarkable. He did not report any allergies. On arrival, his vital signs were stable. However, laboratory examinations demonstrated: white blood cells 26 × 103/μL (4–11), neutrophils 38.8% (35%–72%), lymphocytes 58% (20%–45%), red blood cells 3.59 M/μL (0–0.6), haemoglobin 10.9 g/dL (13.5–17.5), haematocrit 33.4% (40%–54%), platelets 11.5 fL (6.5–11), prothrombin time 13.2 s (9.4–12.5), glucose 70 mg/dL (74–107), sodium 135 mmol/L (137–146), calcium 7.6 mg/dL (8.8–106), serum glutamic-oxaloacetic transaminase 426 U/L (10–45), serum glutamate pyruvate transaminase 530 U/L (7–45), gamma glutamyl transferase 151 U/L (7–49), total albumins 5.3 g/dL (6.6–8.3), C-reactive protein 235 mg/L (<5), and Epstein-Barr virus 15.50 S/CO (0–1.0). In addition, computed tomography determined hepatosplenomegaly, haemoperitoneum, and spleen rupture. Physical examination revealed abdominal rigidity, left shoulder tip pain, shortened capillary refill time, and neck lymphadenopathy. Results The patient underwent expeditious total splenectomy, postoperative period was uneventful and he was discharged on the sixth postoperative day. He was scheduled to undergo the post-splenectomy vaccinations and regular follow-ups with his general practitioner abroad. Conclusion In patients without a history of trauma, spontaneous splenic rupture should be considered in the differential diagnosis if patients have complaints of abdominal and left shoulder tip pain, and laboratory results indicate low haemoglobin and haematocrit levels.
Knowledge, attitude, and practice towards Hepatitis B and vaccination status of pre-clinical medical students at Sylhet Women’s Medical College, Bangladesh
Authors: Lamichhane Ramesh , Adhikari Pritha , Pathak Bishnu Deep , Rai Aashika , Ojha Pratikshya , Maharjan Kripa , Ruche Hamida Sultana , Saha Madhusudan 
Published: November 2024

Background
Hepatitis B is a global health problem with high morbidity and mortality. The risk of transmission is more common among health care personnels and medical students during their professional health trainings. Vaccination is the most effective means of prevention. The main objective of this study was to determine the level of knowledge, attitude, and practice regarding Hepatitis B and vaccination among pre-clinical students in a medical college.

Materials and methods
A web-based, single-center, descriptive cross-sectional study was conducted among pre-clinical medical students in Bangladesh from April 28, 2024, to May 4, 2024. The whole sampling technique method was used taking the entire population for our study. Data were collected using a self-administered questionnaire and analyzed using JMP Pro V17 Statistical Software.

Results
Sixty-one (34%) students were vaccinated against Hepatitis B, of whom 18% received all three doses with a booster dose. The most common reason for non-vaccination was lack of awareness of one’s vaccination status (43%). The median knowledge, attitude, and practice (KAP) scores were 54 (50–60), 19 (17–21) and 20 (19–23) respectively, and they were moderately positively correlated. Forty-six (25.98%) students had a good overall KAP score (≥ 102).

Conclusion
Only one-third of the students had been vaccinated, and the commonest reason for non-vaccination was lack of awareness of one’s vaccination status. Nearly one-fourth of the participants had good knowledge, attitude, and practice related to Hepatitis B. Therefore, education regarding Hepatitis B infection, risk factors, and importance of vaccination is a must among pre-clinical medical students in Bangladesh.
Systematic review and meta-analysis of recombinant herpes zoster vaccine in immunocompromised populations
Authors: Marra Fawziah , Yip Michael , Cragg Jacquelyn J. , Vadlamudi Nirma Khatri 
Published: November 2024

Importance
Herpes zoster infection is common in immunocompromised individuals. Recently, the Advisory Committee on Immunization Practices recommended immunizing with the recombinant zoster vaccine (RZV).

Objective
To evaluate the efficacy, immunogenicity and safety of RZV in immunocompromised individuals, such as transplant recipients, cancer patients undergoing chemotherapy, individuals with preexisting autoimmune diseases and HIV-infected patients.

Data sources and selection
From January 1984 to October 2023, a systematic search of PubMed, MEDLINE, EMBASE, Scopus, Web of Science, CINAHL, and Cochrane CENTRAL was performed. Randomized clinical trials (RCT) evaluating RZV compared to placebo in immunocompromised adults were selected.

Data extraction
Study characteristics and estimates on the incidence of herpes zoster, immune responses, and safety data were extracted from studies. Estimates were pooled using random-effects meta-analysis. Differences by study-level characteristics were estimated using subgroup meta-analysis and metaregression.

Results
Seven RCTs were included. Compared to placebo, RZV reduced the incidence of herpes zoster across all ages by 81% (RR: 0.19, 95%CI: 0.09, 0.44), with moderate heterogeneity across the studies (I2 = 60.49%; τ2 = 0.31; P = 0.07). RZV significantly increased humoral and cellular immunity one month after the last dose. Transplant and past malignancy were associated with lower immunogenicity. RZV was more reactogenic with more local and systemic adverse events. There was no difference in serious adverse events or death between the two arms.

Conclusion
This study suggests that RZV reduces the risk of herpes zoster infection in immunocompromised individuals. This vaccine should be routinely offered to immunocompromised individuals, preferably before chemotherapy or treatment.
Validation of the biological function and prognostic significance of AURKA in neuroblastoma
Authors: Chu Jing 
Published: November 2024

Background
Neuroblastoma (NB) is the most common extracranial solid tumor in children, and the AURKA gene encodes a protein kinase involved in cell cycle regulation that plays an oncogenic role in a variety of human cancers. The aim of this study was to validate the biological function and prognostic significance of AURKA in NB using basic experiments and bioinformatics.

Methods
Data obtained from Target and GEO databases were analyzed using various bioinformatic techniques. The expression of AURKA in 77 NB samples was detected by immunohistochemistry (IHC) method. The lentiviral RNA interference technique was employed to downregulate AURKA gene expression in NB cell lines. Additionally, cell counting kit-8 and flow cytometry analysis were conducted to investigate the impact of AURKA expression on cell proliferation, cell cycle progression, and apoptosis.

Results
A bioinformatic analysis showed that patients with NB in the AURKA-high-expression group had shorter OS (Overall Survival). Immune cell infiltration analysis showed that only activated CD4 T cell and type 2 T helper cell infiltration levels were higher in the AURKA-high-expression group than in the AURKA-low-expression group, with the infiltration levels of most other immune cells and cytokines lower in the high-expression group. Furthermore, the enhanced infiltration of activated CD4 T cells was associated with worse OS in patients with NB.
IHC results showed that the AURKA expression was correlated with MYCN status and INSS stage. Log-rank test showed that pathological type, MYCN status, INSS stage, COG risk group, and AURKA expression was related to PFS (Progression-free survival) of NB patients, but COX regression analysis showed that none of the above factors were independently prognostic for PFS.
In vitro, shRNA delivered via an AURKA-specific lentivirus significantly and consistently silenced endogenous AURKA expression in the human NB cell line SK-N-AS. This inhibited tumor cell proliferation, induced apoptosis, and caused G2/M-phase cell cycle arrest. Moreover, western blot assay showed significant reductions in the levels of mTOR, p70S6K, and 4E-BP1 phosphorylation in the AURKA-knockdown group. I found in subsequent experiments that NFYB can bind to the AURKA promoter and thus promote AURKA expression.

Conclusions
High-level AURKA expression in NB is associated with poor patient prognosis. Silencing AURKA inhibited tumor cell proliferation, induced tumor cell apoptosis, and led to cell cycle arrest in the G2/M phase. Mechanistically, AURKA knockdown inhibited the phosphorylation and the activation of the mTOR1/p70S6K/4E-BP1 signaling pathway. In addition, AURKA was observed to regulate the infiltration levels of various immune cells in the NB tumor microenvironment, resulting in remodeling of the immunosuppressive tumor microenvironment.
INHOMOGENEITY OF ULTRASOUND FIELD DURING SONICATION EXPERIMENTS IN VITRO AND ITS INFLUENCE ON THE OVERALL AMOUNT OF ULTRASOUND ENERGY ENTERING A SONICATION VESSEL
Authors: Snehota Martin , Vachutka Jaromir , Dolezal Ladislav , Balazova Klara , Kolarova Hana 
Published: November 2024

Current sonication experiments in vitro show immense variability in experimental set-ups and equipment used. Many factors such as presence of standing waves or position of sonicated sample in ultrasound field during the experiment affect ultrasound field parameters the sonicated samples actually experience. The main goal of this work was to quantify influence of position of sonicated sample on maximum acoustic intensity and overall amount of ultrasound energy entering sonication vessel when placed at different distances from ultrasound transducer. The measurements were performed in a water sonication tank with use of a circular unfocussed ultrasound transducer (d = 19 mm) and needle hydrophone (d = 0.5 mm). The measurements showed that the differences in amount of ultrasound energy (maximum and minimum energy were compared) entering particular well per time unit at different distances from ultrasound transducer range from 45.5% (48-well culture plate) to 109.9% (96-well culture plate). Moreover, the maximum acoustic intensity of ultrasound field entering particular well can differ by up to 233.2%. Therefore, position of sonicated sample in ultrasound field should not be neglected during sonication experiments in vitro.
THE PRODUCTION OF HYBRID PROSTHETIC SOCKETS THROUGH THE INTEGRATION OF 3D PRINTING AND CONVENTIONAL LAMINATION
Authors: Štefanovič Branko , Bednarčíková Lucia , Michalíková Monika , Hudák Radovan , Živčák Jozef 
Published: November 2024

Currently, due to the relatively high number of active users with amputation of the lower limbs, it is important to increase user comfort, innovate and optimize the connection between the residual limb and the prosthesis, i.e. the prosthetic socket. The purpose of this work is to combine the potential and advantages of both conventional and innovative (modern) production processes for the design and fabrication of personalized hybrid sockets to optimize production, comfort, and patient safety. The socket was designed and constructed for a highly active user (Functional Classification Level 4) to ensure comfort and safety during high-stress sports activities (skiing). Unlike traditional plastering, a 3D scanner was used to take measurement data. The 3D model of the stump was edited in a software environment instead of laborious and lengthy processing of the plaster positive. Subsequently, a matrix of the prosthetic socket was made from PETG material using FFF 3D printing, which was laminated to increase strength. 3D printed samples of PETG material were tested for tension and pressure according to the relevant standard (EN ISO 527-2: 1996). The last phase was static and dynamic testing of the hybrid socket. No deviations were recorded in the monitored parameters, both at a slow (1.0 km/h) and at a standard (2.5 km/h) walking speed. Once the socket integrity has been assessed, a greater dynamic load was initiated in the form of activities with higher dynamic levels (lateral leaning on the knee and jumps). According to the test results, there has been no change in the shape or integrity of the socket, and the subjective point of view of the volunteer rated the hybrid prosthetic socket as comfortable.
Outreach, education and knowledge mobilization for effective use of ecosystem-based approaches
Authors: Kellogg Wendy , Dhaliwal Navjot , Barrette-Ng Isabelle , Gelderloos Orin , Hartig John , Lisuk Juliana , McLaughlin Chris 
Published: November 2024

Abstract
An ecosystem-based approach requires an integration of knowledge systems and collaborative practices. The purpose of outreach, education, and knowledge mobilization is to (1) enhance the environmental literacy of people about the critical ecological and social functions of their ambient ecosystems; and (2) to enhance the production of information, the availability of information across the greatest range of stakeholders, and the transformation of information into experiential knowledge. We focus on these two purposes in the Laurentian Great Lakes of North America, where an ecosystem approach has been a guiding framework for policy and programming for decades. A literature review of outreach, education, and knowledge mobilization is presented with several supporting exemplar case studies and a concluding discussion of interconnected characteristics of outreach, education and knowledge mobilization that include intersectionality, place-based engagement, systems perspective, collaboration, and governance network learning capacity. Recommendations for practice focus on the importance of community engagement, community science, communities of practice, bridging organizations, watershed councils, governmental and other partnerships, financial supports and incentives, access to data, professional development, and policy development.
Indigenous ways of being and the Ecosystem Approach
Authors: Nolan Shayenna , Duncan Alexander T. , Donaldson Candy , Jacobs Clint , Chegahno Anthony “Miptoon” , Cedar Karen , Eco-Keepers Bkejwanong , Febria Catherine 
Published: November 2024

Abstract
Indigenous knowledge systems, ways of knowing and being have long been ignored or erased in the science, policy, and management of ecosystems. Through the 2022 Ecosystem Approach Conference and Synthesis Workshop focusing on Indigenous relationships, we facilitated discussions which raised key concerns from Indigenous led environmental teams: funding, collaborations, work/life balance, Indigeneity/Western/colonial balance, and racism. We discuss how conceptions of the Ecosystem Approach are synonymous with Indigenous management by definition and practice. Drawing on specific examples raised in workshop discussions and from the literature, we highlight how holistic approaches to the caring for and science of ecosystems have long been the way of Indigenous communities locally, globally, and across generations. To elevate these approaches and support this holistic vision of having relationship with ecosystems, we collectively call for better avenues of funding and responsive structures to support Indigenous-led initiatives. This requires that first we recognize Indigenous sovereignty and as settler and non-Indigenous scientists we invest in and maintain real relationships by listening to and standing with Indigenous Peoples in an effort to better support care for their Lands, Waters, and Kiin.
Assessing and implementing the concept of Blue Economy in Laurentian Great Lakes fisheries: Lessons from coupled human and natural systems
Authors: Carlson Andrew K. , Leonard Nancy J. , Munawar Mohiuddin , Taylor William W. 
Published: November 2024

Abstract
Inland fisheries often receive little to no attention in global discussions about sustainable development. The consequences of overlooking inland fisheries in sustainability dialogues are increasingly problematic as fisheries stressors (e.g. overharvest, species invasion, climate change, habitat modification) intensify. Elevating the global profile of inland fisheries requires an approach for quantifying and clearly conveying the ecological, economic, and societal values of these systems. One such approach involves the Blue Economy, a multifaceted concept initially used to describe the intersection of marine conservation and sustainable use of marine resources for economic growth. Although conceptually powerful, the Blue Economy has rarely been applied to inland waters and fisheries. To address this knowledge gap, we conceptualized Laurentian Great Lakes fisheries from a Blue Economy perspective. In particular, we evaluated the utility of the coupled human and natural systems framework for characterizing the ecological, economic, and societal values of Laurentian Great Lakes fisheries and associated contributions to the Blue Economy (e.g. human livelihoods, food security, recreation, conservation, economic prosperity). There are numerous opportunities to leverage Coupled Human and Natural Systems methods (e.g. metacoupling, telecoupling) and associated mathematical models to advance fisheries science, inform fisheries management, and ultimately move toward a Blue Economy in the Laurentian Great Lakes. To that end, we demonstrated applications of these methods, discussed strategies for communicating with stakeholders, and provided insights for navigating challenges to developing a Blue Economy in the Laurentian Great Lakes—a model that could be used in the African Great Lakes and other large ecosystems in the world.
The use of advanced and emerging technologies for adaptive ecosystem-based management of the Great Lakes
Authors: Verhamme Edward M. , Bratton John F. , Austin Jay A. , Binding Caren E. , Collingsworth Paris D. , Dick Gregory J. , Grand Joanna , Hartig John H. , Henderson Hayden M. , McKay R. Michael , Pioro-McGuire Basia , Riseng Catherine M. , Varga Emily 
Published: November 2024

Abstract
The Great Lakes and connecting waters encompass a vast and diverse ecosystem that presents scale challenges for management similar to those of the coastal ocean. Technological approaches to overcome the scale challenges have primarily been adapted from oceanographic applications and technologies, and from upscaling inland lake methods designed for shallower and calmer water bodies. Many standard methods for studying Great Lakes habitat and biota have long lag times between field collection and data availability. Many also miss much of the dynamics, three-dimensional complexity, and spatial variability needed to manage the system effectively. Even baseline conditions are not well characterized for many parts of the Great Lakes ecosystem (e.g. bathymetry and critical habitat, life cycles and food webs, night and winter movement and activity of organisms). Emerging technologies are beginning to address these needs but require coordination, consistent investment, training, and governance linkages. Here we survey recent technological advances and show how they are contributing to improved adaptive management of the Great Lakes ecosystem by reducing uncertainty and increasing understanding of physical, biological, and chemical processes, and the human dimensions of resource management and restoration.
Geschichten vom Ingenieur
Authors: Krah Hans 
Published: November 2024

Abstract
Based on various representative examples, this article shows which images of the “Ingenieur” (engineer) appear in narratives written in German, focusing on the years 1900 to 1930. While a general type of engineers appears as a representative of progress and a hallmark of the time, incorporating this conception as the norm, three further models can be identified, which are embedded within conflicting constellations of normality/deviation, daily routine/emotional emphasis, and the collective/individual: the engineer as a figure who mediates the crossing of borders, the engineer as a condensation of a life felt to be deficient, the engineer as the savior of the world.
Ingenieure (in) der Deutschen Rundschau
Authors: Scherer Stefan 
Published: November 2024

Abstract
The Deutsche Rundschau (since 1874) is representing a new model of review which celebrates technical advance as a means of the unity of national culture during the German Empire through incorporating this progress into a general history of culture. For that the so called poet-engineer plays a pivotal role as he appraises the cultural value of technology. The contributions of Max Maria von Weber to the Deutsche Rundschau can teach how an aristocrat tries to make technology acceptable as a cultural issue by proving its relevance against the background of values of the Goethezeit.