bluuebunny/crossref_metadata_2025_split huggingface dataset:
Greater mindfulness associated with lower pain, fatigue, and psychological distress in women with metastatic breast cancer
Authors: Zimmaro Lauren A. , Carson James W. , Olsen Maren K. , Sanders Linda L. , Keefe Francis J. , Porter Laura S. 
Published: September 2019

AbstractObjectiveWomen with metastatic breast cancer (MBC) report high levels of disease‐related symptoms including pain, fatigue, psychological distress, and sleep disturbance. Mindfulness may be particularly relevant to women with MBC given the high symptom burden and psychological toll of this disease; however, the topic is understudied among this patient population. Therefore, we aimed to test the associations between mindfulness and patient‐reported symptoms among a sample of women with MBC.MethodsSixty‐four women with MBC completed baseline questionnaires of mindfulness (Five Facet Mindfulness Questionnaire‐Short Form [FFMQ‐SF]) and symptoms of pain severity and interference, fatigue, psychological distress, and sleep disturbance as part of a randomized controlled trial of a Mindful Yoga intervention. Correlational analyses of data collected at baseline tested associations between the five mindfulness facets (observing, describing, acting with awareness, nonjudging, and nonreactivity) and patient‐reported measures of symptoms.ResultsOverall, higher mindfulness was associated with lower symptom levels including lower pain severity, pain interference, fatigue, anxiety, depression, and sleep disturbance. However, degree of association varied by mindfulness facet. Nonreactivity, nonjudging, and describing showed the most frequent associations and largest effect sizes across symptoms, while observing showed the least frequent associations and lowest effect sizes.ConclusionsMindfulness—and in particular nonreactivity, nonjudging, and describing—may be a personal resource for women with MBC in coping with complex symptoms of this life‐threatening illness. Findings are discussed relative to their implications for interventions aimed at increasing mindfulness in this vulnerable population.
Knockdown of COPS3 inhibits the progress of prostate cancer through reducing phosphorylated p38 MAPK expression and impairs the epithelial‐mesenchymal transition process
Authors: Zhu Zhenjie , Hong Yang , Zhang Fengshi , An Lizhe , Yang Qingya , Huang Xiaobo , Xu Qingquan 
Published: September 2019

AbstractBackgroundThe amplification of gene COPS3 is closely related to the development of osteosarcoma and hepatocellular carcinoma. However, the effects of COPS3 on prostate cancer (PCa) are poorly understood.MethodsIn this study, the protein expression of COPS3 in PCa tissues, adjacent normal tissues, and bone metastasis tissues of PCa was analyzed by immunohistochemistry. Furthermore, cell proliferation, colony formation, migration, and invasion assay were performed in 22rv1 and PC‐3 cells after knocking down COPS3 by small interfering RNAs. Furthermore, we performed western blot analysis to explore the potential mechanisms underlying it.ResultsThis study found that the overall survival of the COPS3 high‐expression group was significantly shorter than the low‐expression group. This study discovered that the protein expression of COPS3 in PCa tissues was higher than that in the matched nontumor prostate tissues. In addition, tissues from bone metastasis of PCa had a high percentage of overexpressing COPS3. After knockdown of the COPS3 gene in 22rv1 and PC3 cells, two classic human PCa cell lines which had a high level of COPS3, the abilities of migration, invasion, and proliferation were inhibited. Finally, protein levels of phosphorylated P38 mitogen‐activated protein kinase (MAPK) and N‐cadherin were significantly decreased after knocking down the expression of COPS3, and the protein levels of E‐cadherin were significantly increased.ConclusionsIn conclusion, COPS3 may be closely related to the progress of PCa. Knockdown of COPS3 inhibited the progress of PCa through reducing the levels of phosphorylated P38 MAPK and impaired the epithelial‐mesenchymal transition process.
Mass spectral studies of silyl derivatives of partially hydrolyzed products of nitrogen mustards: Important markers of nitrogen mustard exposure
Authors: Chandra Buddhadeb , Sinha Roy Kanchan , Shaik Mahabul , Waghmare Chandrakant , Palit Meehir 
Published: September 2019

RationaleNitrogen mustards (NMs) are vesicant class of chemical warfare agents. From the viewpoint of the Chemical Weapons Convention partially hydrolyzed products of nitrogen mustards (pHpNMs) are considered as important markers of nitrogen mustard exposure. The detection of pHpNMs from biological or environmental samples is highly useful for obtaining forensic evidence of exposure to NMs.MethodsGas chromatography interfaced with tandem mass spectrometry (GC/MS/MS) is a widely used tool for the identification and sensitive detection of metabolites of NMs in complex matrices. The pHpNMs were derivatized using silylating agents as they are highly polar and non‐amenable to GC. The mass spectral studies of these silyl derivatives of pHpNMs were performed using GC/MS/MS in both electron ionization (EI) and chemical ionization (CI) mode.ResultsVarious approaches have been proposed to assess the fragmentation pathways of the trimethylsilyl (TMS) and tert‐butyldimethylsilyl (TBDMS) derivatives of pHpNMs. All the proposed fragmentation pathways were based on the product and/or precursor ion scanning of corresponding ions in both EI and CI mode. In the case of EI, most of the fragmentation pathways involved either α‐cleavage or inductive cleavage.ConclusionsThis is the first report on the MS study of the silyl derivatives of pHpNMs. The study of the two different derivatives of pHpNMs using both EI‐ and CI‐MS provides a reliable, unambiguous identification of pHpNMs in complex environmental and biomedical matrices (such as plasma and urine) during any verification activities.
Effects of preservation methodology on stable isotope compositions of sea stars
Authors: Le Bourg Baptiste , Lepoint Gilles , Michel Loïc N. 
Published: September 2019

RationaleStable isotope analysis is used to investigate the trophic ecology of organisms and, in order to use samples from archived collections, it is important to know whether preservation methods alter the results. This study investigates the long‐term effects of four preservation methods on isotopic compositions and isotopic niche parameters of sea stars.MethodsWe assessed the effects of preservation method (freezing, drying, formaldehyde, ethanol) and duration (0, 1, 3, 6, 9, 12, 24 months) on the stable isotope ratios of carbon, nitrogen and sulfur of sea star tissues. Isotopic ratios were measured using continuous‐flow elemental analysis and isotope ratio mass spectrometry. We also monitored the evolution of commonly used ecological metrics (isotopic niche parameters) throughout the experiment.ResultsClear changes in δ13C values were observed for samples stored in formaldehyde and ethanol. None of the preservation methods had significant or consistent effects on δ15N values. Formaldehyde preservation induced a decrease in δ34S values. All these changes could be mitigated using correction factors. Isotopic niche parameters slightly changed over time when computed with δ13C and δ15N values, but inconsistent variations occurred when computed with δ13C and δ34S values.ConclusionsOverall, these results show that preservation may affect the stable isotope ratios of sea stars. Correction factors can be used to mitigate the effects of the preservation method on stable isotope ratios. Isotopic niche parameters are overall unchanged. Consequently, in most cases, museum samples are suitable for calculation of isotopic niche parameters.
Developing an intelligent tutoring system for robotic‐assisted surgery instruction
Authors: Julian Danielle , Smith Roger 
Published: September 2019

AbstractBackgroundRobotic‐assisted laparoscopic surgery (RALS) is an operative innovation that has sparked global interest. Over the last decade, RALS cases have rapidly increased with over 750 000 robotic procedures completed in 2017. Until recently, Intuitive's da Vinci surgical system has been the only Food and Drug Administration (FDA)–approved robotic‐assisted surgical device for human procedures. Robotic procedures with the da Vinci require a specific, dedicated training due to the introduction of the technological components and psychomotor skills needed to successfully utilize this system. When a surgeon becomes interested in learning robotics, there are limited avenues for training. Surgeons typically receive instruction on the necessary psychomotor and Operation Room (OR) communication skills in isolation from the cognitive and perceptual skills and may only perform these skills in an integrated manner during a 1‐ or 2‐day course.MethodsThis paper discusses the development of a computer‐based intelligent tutoring system (ITS) to train the cognitive and procedural skills needed to complete basic robotic suturing to novice robotic surgeons. The system was developed using the generalized intelligent framework for tutoring framework of tools. This information was captured as video, instruction sets, and flowcharts, which were reviewed for accuracy by surgeons and then encoded into an ITS using the generalized intelligent framework for tutoring tools.ConclusionThe purpose of this paper was threefold—(a) explain the process used to obtain the critical data behind a basic robotic task, (b) develop an entry‐level ITS to train the cognitive process and procedural steps behind multiple fundamental robotic surgery skills, and (c) provide future novice ITS developers lessons learned and future recommendations beyond the initial ITS prototype.
Stabilization of polytopes of plants by their vertices
Authors: Fonte Christophe , Meddeb Houda , Zasadzinski Michel 
Published: September 2019

SummaryThis paper aims to assess the stability of a polytope of linear systems by their vertices. These results are based on the Hermite‐Biehler and Edge theorems. A sufficient condition satisfying a constraint on the even (or odd) part of the closed‐loop characteristic polynomials associated with the stabilization of its vertices is proved. Finally, a constructive method to stabilize a polytope of plants with simultaneous and robust linear time‐invariant controllers is established.
Stability and stabilization of nonlinear discrete‐time stochastic systems
Authors: Jiang Xiushan , Tian Senping , Zhang Tianliang , Zhang Weihai 
Published: September 2019

SummaryThis paper mainly studies the locally/globally asymptotic stability and stabilization in probability for nonlinear discrete‐time stochastic systems. Firstly, for more general stochastic difference systems, two very useful results on locally and globally asymptotic stability in probability are obtained, which can be viewed as the discrete versions of continuous‐time Itô systems. Then, for a class of quasi‐linear discrete‐time stochastic control systems, both state‐ and output‐feedback asymptotic stabilization are studied, for which, sufficient conditions are presented in terms of linear matrix inequalities. Two simulation examples are given to illustrate the effectiveness of our main results.
Discovery of retinoic acid receptor agonists as proliferators of cardiac progenitor cells through a phenotypic screening approach
Authors: Drowley Lauren , McPheat Jane , Nordqvist Anneli , Peel Samantha , Karlsson Ulla , Martinsson Sofia , Müllers Erik , Dellsén Anita , Knight Sinead , Barrett Ian , Sánchez José , Magnusson Björn , Greber Boris , Wang Qing-Dong , Plowright Alleyn T. 
Published: September 2019

Abstract
Identification of small molecules with the potential to selectively proliferate cardiac progenitor cells (CPCs) will aid our understanding of the signaling pathways and mechanisms involved and could ultimately provide tools for regenerative therapies for the treatment of post-MI cardiac dysfunction. We have used an in vitro human induced pluripotent stem cell-derived CPC model to screen a 10,000-compound library containing molecules representing different target classes and compounds reported to modulate the phenotype of stem or primary cells. The primary readout of this phenotypic screen was proliferation as measured by nuclear count. We identified retinoic acid receptor (RAR) agonists as potent proliferators of CPCs. The CPCs retained their progenitor phenotype following proliferation and the identified RAR agonists did not proliferate human cardiac fibroblasts, the major cell type in the heart. In addition, the RAR agonists were able to proliferate an independent source of CPCs, HuES6. The RAR agonists had a time-of-differentiation-dependent effect on the HuES6-derived CPCs. At 4 days of differentiation, treatment with retinoic acid induced differentiation of the CPCs to atrial cells. However, after 5 days of differentiation treatment with RAR agonists led to an inhibition of terminal differentiation to cardiomyocytes and enhanced the proliferation of the cells. RAR agonists, at least transiently, enhance the proliferation of human CPCs, at the expense of terminal cardiac differentiation. How this mechanism translates in vivo to activate endogenous CPCs and whether enhancing proliferation of these rare progenitor cells is sufficient to enhance cardiac repair remains to be investigated.

Significance statement Progenitor cells are rare and difficult to isolate, and little is known about the molecular mechanisms required for their proliferation and differentiation. Identification of small molecules that selectively proliferate cardiac progenitor cells will aid in the understanding of the signaling mechanisms involved and could provide tools for regenerative therapies for the treatment of cardiac dysfunction. A phenotypic screen identified retinoic acid receptor agonists as potent proliferators of induced pluripotent stem cell-derived cardiac progenitor cells. The agonists did not proliferate human cardiac fibroblasts, the major cell type in the heart but did proliferate human pluripotent stem cells, HuES6, in a time-of-differentiation-dependent manner.
Are the Sustainable Development Goals self‐consistent and mutually achievable?
Authors: Dawes Jonathan H.P. 
Published: September 2019

AbstractOn September 18, 2015, the United Nations General Assembly adopted the 2030 Agenda for Sustainable Development, which sets out wide‐ranging ambitions for global development. In response to the 2030 Agenda, the International Council for Science (ICSU), in partnership with the International Social Science Council (ISSC), subsequently published a detailed commentary on the Sustainable Development Goals (SDGs) and the linkages between them.The ICSU–ISSC Report raises the possibility that the SDG framework as a whole might not be internally self‐consistent, and the report itself calls for a wider “systems perspective.”In this paper, we use the ICSU commentary as the basis for a quantitative theoretical analysis of the SDGs from a systems perspective. We provide a mathematical definition of self‐consistency and show that the linkages we infer from the ICSU–ISSC report imply that the SDGs are not self‐consistent.However, using a simple dynamical model to investigate the combined outcome of direct efforts at tackling each Goal and the indirect effects on progress due to network effects, we show that network effects could be used to secure better outcomes on every Goal than would be possible if linkages between Goals did not exist at all. These better outcomes would be possible through an unequal, targeted reallocation of direct efforts. Unequal distribution of direct effort can therefore make the SDGs mutually achievable.These conclusions contribute to the ongoing debate on the development of global strategies for the achievement of the 2030 Agenda, their implementation, and the definition and monitoring of progress towards the Goals.
From Concentrated Dispersion to Solid β‐Cyclodextrin Polymer‐Capped Silver Nanoparticle Formulation: A Trojan Horse Against Escherichia coli
Authors: Martin‐Trasanco Rudy , Anziani‐Ostuni Giovanna , Esparza‐Ponce Hilda Esperanza , Ortiz Pedro , Montero‐Cabrera María E. , Oyarzún Diego P. , Zúñiga César , Pérez‐Donoso José Manuel , Pizarro Guadalupe del C. , Arratia‐Pérez Ramiro 
Published: September 2019

AbstractPreparation of concentrated silver nanoparticles in water remains a challenge today. The intrinsic reactivity of silver, as well as the high surface energy of nanoparticles, make it difficult to handle them without altering their pristine properties. Herein, we report the preparation of concentrated silver nanoparticles (AgNPs) dispersion (2 mM; 1.5⋅1015 NPs/mL) by reducing Ag+ in‐situ of a β‐cyclodextrin‐epichlorohydrin polymer (βCDP) as a capping agent. The prepared nanoparticles (AgNPs@βCDP) with a Surface Plasmon Resonance band at 396 nm, and a hydrodynamic diameter of 21.4 ±1.8 nm, retained both features after being precipitated and re‐dispersed in water. The AgNPs core had a spherical morphology, with a 12.7 ±1.5 nm diameter in size, as determined by TEM. The AgNPs@βCDP showed outstanding bactericidal properties against Escherichia coli (MIC= 0.37 nM), one of the lowest ever achieved for silver nanoparticles. We suggest that the polymer acts as a Trojan horse with AgNPs as payload.
A Novel and Efficient Colorimetric Assay for Quantitative Determination of Amlodipine in Environmental, Biological and Pharmaceutical Samples
Authors: Yaqoob Sana , Rahim Sana , Bhayo Adnan Murad , Shah Muhammad Raza , Hameed Abdul , Malik Muhammad Imran 
Published: September 2019

AbstractDevelopment of facile, on‐spot, robust, and efficient optical nanosensors for drugs and pesticides is one of the active research area. In this study, a nanosensor based on fairly stable silver nanoparticles (AgNPs) conjugated with specially designed thiourea (TU)‐based molecule, N‐((4‘‐methoxy‐2‘‐nitrophenyl) carbamothioyl) dodecanamide (TU3), was prepared using one pot protocol and characterized by Ultraviolet (UV)‐Visible spectroscopy, dynamic light scattering (DLS), fourier transform infrared (FTIR) spectroscopy and atomic force microscopy (AFM). The TU3 conjugated AgNPs (TU3‐AgNPs) were found to be selective spectrophotometric sensor for an antimicrobial drug, amlodipine (Ad), among the pool of different drugs. TU3‐AgNPs based nanosensor allows for the rapid quantitative assay having a detection limit of 0.3 μM in an analytical range of 0.1‐100 μM. The proposed sensor is specific in presence of number of other interfering drugs and other matrix. Upto the best of our literature survey, this is first ever colorimetric sensor for quantification of amlodipine in complex matrix. The specificity of the sensor allows for quantitative detection of amlodipine in environmental, biological and pharmaceutical samples.
Two‐Step Preparation of Diverse 3‐Amidofurans from Chitin
Authors: Pham Thuy Trang , Lindsay Ashley C. , Kim Shi‐Wei , Persello Laly , Chen Xi , Yan Ning , Sperry Jonathan 
Published: September 2019

AbstractThe synthesis of 3‐amidofurans is laborious due to the difficulty installing a nitrogen substituent at the C3 position of the furan heterocycle. 3‐Acetamido‐5‐acetylfuran (3A5AF), readily available from chitin, is a versatile biorenewable platform that can be converted into a range of functionally rich 3‐amidofurans, streamlining access to this underexplored heteroaromatic chemical space.
The dynamic interplay of physical and psychosocial safety climates in frontline healthcare
Authors: McLinton Sarven S. , Afsharian Ali , Dollard Maureen F. , Tuckey Michelle R. 
Published: September 2019

AbstractLittle is known about how safety climates concerning physical safety and psychosocial safety interact in the prediction of working conditions and subsequent worker health. Frontline healthcare was selected as the setting for this study on the dynamic interplay between physical and psychosocial safety climates because of a recent call for attention to working conditions in this industry. Poor safety climates for healthcare workers spill over into adverse outcomes for worker health, and when workers are compromised, then so too is their provision of quality patient care. We developed an integrated model of the relationships between psychosocial and physical safety climates, working conditions, and health and safety outcomes. A multilevel model was tested (N = 463 workers nested within n = 60 teams), and lagged analysis was conducted across four time points, each 6 months apart. The combination of safety climates significantly predict objective outcomes from hospital safety system records on staff accidents, absence, and patient incidents (quality of care), suggesting a dynamic interplay in the prediction of impacts on the worker, organization, and end‐user. Integrated physical and psychosocial safety climate measures can be incorporated into hospital occupational health and safety reporting and response systems as effective lead indicators and key performance metrics for work health and safety.
When your problem becomes my problem: The impact of airline IT disruptions on on‐time performance of competing airlines
Authors: Tae C. Jennifer , Pang Min‐Seok , Greenwood Brad N. 
Published: September 2019

AbstractResearch SummaryWe study the effect of firm disruptions on competitor performance in the presence of shared resources in the U.S. airline industry. While scholars have investigated both the effects of industry‐wide and firm‐specific disruptions, little work has examined the effect on competitors, who are increasingly reliant on interconnected resources in the digital age. Results from a series of recent information technology (IT) outages indicate that performance is materially affected by a competitor's disruption. While the disruption of a full‐service carrier significantly delays flights of all airlines leveraging its hubs, the exact opposite is observed during the disruption of a low cost carrier. Further, the effect is strongly moderated by the type of airlines reacting to the disruption. Implications for managers and theory are discussed within.Managerial SummaryWhat happens to my operations when a competitor's operations are disrupted? While research has examined how a disrupted firm can recover, little attention has been paid to competitors, except their ability to exploit the disruption for economic gain. This is problematic, as firms increasingly leverage interconnected resources and infrastructure. We show that an airline's IT outages affect on‐time performance of competitors' flights to and from its hub airports. However, the effects depend on both who is disrupted, and who is reacting to that disruption. The disruptions of full‐service carriers (FSCs) delay competitors' flights, but that of a low‐cost carrier (LCC) leads to early arrivals and departures. Further, LCCs are significantly more nimble reacting to disruptions compared to FSCs.