bluuebunny/crossref_metadata_2025_split huggingface dataset:
External Soft-Tissue Hemostatic Clamp Compared to a Compression Tourniquet as Primary Hemorrhage Control Device in Pilot Flow Model Study
Authors: Paquette Roland , Bierle Ryan , Wampler David , Allen Paul , Cooley Craig , Ramos Rosemarie , Michalek Joel , Gerhardt Robert T. 
Published: March 2019

Introduction:Acute blood loss represents a leading cause of death in both civilian and battlefield trauma, despite the prioritization of massive hemorrhage control by well-adopted trauma guidelines. Current Tactical Combat Casualty Care (TCCC) and Tactical Emergency Casualty Care (TECC) guidelines recommend the application of a tourniquet to treat life-threatening extremity hemorrhages. While extremely effective at controlling blood loss, the proper application of a tourniquet is associated with severe pain and could lead to transient loss of limb function impeding the ability to self-extricate or effectively employ weapons systems. As a potential alternative, Innovative Trauma Care (San Antonio, Texas USA) has developed an external soft-tissue hemostatic clamp that could potentially provide effective hemorrhage control without the aforementioned complications and loss of limb function. Thus, this study sought to investigate the effectiveness of blood loss control by an external soft-tissue hemostatic clamp versus a compression tourniquet.Hypothesis:The external soft-tissue hemostatic clamp would be non-inferior at controlling intravascular fluid loss after damage to the femoral and popliteal arteries in a normotensive, coagulopathic, cadaveric lower-extremity flow model using an inert blood analogue, as compared to a compression tourniquet.Methods:Using a fresh cadaveric model with simulated vascular flow, this study sought to compare the effectiveness of the external soft-tissue hemostatic clamp versus the compression tourniquet to control fluid loss in simulated trauma resulting in femoral and posterior tibial artery lacerations using a coagulopathic, normotensive, cadaveric-extremity flow model. A sample of 16 fresh, un-embalmed, human cadaver lower extremities was used in this randomized, balanced two-treatment, two-period, two-sequence, crossover design. Statistical significance of the treatment comparisons was assessed with paired t-tests. Results were expressed as the mean and standard deviation (SD).Results:Mean intravascular fluid loss was increased from simulated arterial wounds with the external soft-tissue hemostatic clamp as compared to the compression tourniquet at the lower leg (119.8mL versus 15.9mL; P &lt;.001) and in the thigh (103.1mL versus 5.2mL; P &lt;.001).Conclusion:In this hemorrhagic, coagulopathic, cadaveric-extremity experimental flow model, the use of the external soft-tissue hemostatic clamp as a hasty hemostatic adjunct was associated with statistically significant greater fluid loss than with the use of the compression tourniquet.Paquette R, Bierle R, Wampler D, Allen P, Cooley C, Ramos R, Michalek J, Gerhardt RT. External soft-tissue hemostatic clamp compared to a compression tourniquet as primary hemorrhage control device in pilot flow model study.Prehosp Disaster Med. 2019;34(2):175–181
A study on the correlates of habit-, reward-, and fear-related motivations in alcohol use disorder
Authors: Piquet-Pessôa Marcelo , Chamberlain Samuel R. , Lee Rico S. C. , Ferreira Gabriela M. , Cruz Marcelo S. , Ribeiro Ana P. , de Menezes Gabriela B. , Albertella Lucy , Yücel Murat , Fontenelle Leonardo F. 
Published: March 2019

ObjectiveWe assessed self-reported drives for alcohol use and their impact on clinical features of alcohol use disorder (AUD) patients. Our prediction was that, in contrast to “affectively” (reward or fear) driven drinking, “habitual” drinking would be associated with worse clinical features in relation to alcohol use and higher occurrence of associated psychiatric symptoms.MethodsFifty-eight Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV) alcohol abuse patients were assessed with a comprehensive battery of reward- and fear-based behavioral tendencies. An 18-item self-report instrument (the Habit, Reward and Fear Scale; HRFS) was employed to quantify affective (fear or reward) and non-affective (habitual) motivations for alcohol use. To characterize clinical and demographic measures associated with habit, reward, and fear, we conducted a partial least squares analysis.ResultsHabitual alcohol use was significantly associated with the severity of alcohol dependence reflected across a range of domains and with lower number of detoxifications across multiple settings. In contrast, reward-driven alcohol use was associated with a single domain of alcohol dependence, reward-related behavioral tendencies, and lower number of detoxifications.ConclusionThese results seem to be consistent with a shift from goal-directed to habit-driven alcohol use with severity and progression of addiction, complementing preclinical work and informing biological models of addiction. Both reward-related and habit-driven alcohol use were associated with lower number of detoxifications, perhaps stemming from more benign course for the reward-related and lack of treatment engagement for the habit-related alcohol abuse group. Future work should further explore the role of habit in this and other addictive disorders, and in obsessive-compulsive related disorders.
Is problematic exercise really problematic? A dimensional approach
Authors: Chamberlain Samuel R. , Grant Jon E. 
Published: March 2019

Objective:Though moderate exercise has numerous health benefits, some individuals may become excessively preoccupied with exercise, endorsing features akin to “addiction.” The aim of this study was to evaluate the relationships between problematic exercise (viewed dimensionally), quality of life, and psychological measures.Methods:Young adults were recruited from an established population-based cohort in the United Kingdom and completed an online survey. The factor structure of the Exercise Addiction Inventory (EAI) was characterized. Relationships between dimensional EAI factor scores and other variables (impulsivity, compulsivity, emotional dysregulation) were elicited.Results:Six hundred and forty-two individuals took part in the study (mean age 23.4 years, 64.7% female). The EAI yielded two factors – a “general factor” and a “relationship conflict factor.” Both EAI factor scores were associated with disordered eating, impulsivity (UPPS), and compulsivity (CHI-T). Only the relationship conflict factor score was significantly associated with impaired quality of life (all domains) and with maladaptive personality traits (emotional dysregulation and obsessive-compulsive personality disorder traits). Few participants met conventional threshold for full exercise addiction (1.1%).Conclusion:Higher problematic exercise scores, in a sample largely free from exercise addiction, were associated with impulsive and compulsive personality features, emotional dysregulation, and disordered eating. Further research is needed to examine whether these results generalize to other populations (such as gym attendees) and are evident using more rigorous in-person clinical assessment rather than online assessment. Longitudinal research is needed to examine both positive and negative impacts of exercise, since moderate exercise may, in fact, be useful for those with impulsive/compulsive tendencies, by dampening negative emotional states or substituting for other more damaging types of repetitive habit.
Estimating word-level quality of statistical machine translation output using monolingual information alone
Authors: Tezcan Arda , Hoste Véronique , Macken Lieve 
Published: March 2019

AbstractVarious studies show that statistical machine translation (SMT) systems suffer from fluency errors, especially in the form of grammatical errors and errors related to idiomatic word choices. In this study, we investigate the effectiveness of using monolingual information contained in the machine-translated text to estimate word-level quality of SMT output. We propose a recurrent neural network architecture which uses morpho-syntactic features and word embeddings as word representations within surface and syntactic n-grams. We test the proposed method on two language pairs and for two tasks, namely detecting fluency errors and predicting overall post-editing effort. Our results show that this method is effective for capturing all types of fluency errors at once. Moreover, on the task of predicting post-editing effort, while solely relying on monolingual information, it achieves on-par results with the state-of-the-art quality estimation systems which use both bilingual and monolingual information.
Virtual reality-based cognitive behavioural therapy for patients with generalized social anxiety disorder: a pilot study
Authors: Geraets Chris N.W. , Veling Wim , Witlox Maartje , Staring Anton B.P. , Matthijssen Suzy J.M.A. , Cath Danielle 
Published: March 2019

AbstractBackground:Patients with generalized social anxiety disorder (SAD) avoid various social situations and can be reluctant to engage in in vivo exposure therapy. Highly personalized practising can be required before patients are ready to perform in vivo exposure. Virtual reality-based therapy could be beneficial for this group.Aims:To assess the feasibility and potential effect of virtual reality-based cognitive behavioural therapy (VR-CBT) for patients with severe generalized SAD.Methods:Fifteen patients with generalized SAD attended up to 16 VR-CBT sessions. Questionnaires on clinical and functional outcomes, and diary assessments on social activity, social anxiety and paranoia were completed at baseline, post-treatment and at 6-months follow-up.Results:Two patients dropped out of treatment. Improvements in social anxiety and quality of life were found at post-treatment. At follow-up, depressive symptoms had decreased, and the effect on social anxiety was maintained. With respect to diary assessments, social anxiety in company and paranoia were significantly reduced by post-treatment. These improvements were maintained at follow-up. No increase was observed in social activity.Conclusions:This uncontrolled pilot study demonstrates the feasibility and treatment potential of VR-CBT in a difficult-to-treat group of patients with generalized SAD. Results suggest that VR-CBT may be effective in reducing anxiety as well as depression, and can increase quality of life.
Decolonising Museums: South-Asian Perspectives
Authors: GAMBERI VALENTINA 
Published: March 2019

AbstractThis study adopts an osmotic ethnography in order to decolonise the museum as an intellectual institution that was born in the West and informed by a logic of command (arkheion). As in the biological process of osmosis, characterised by an equilibrium between the inner and the outer that shapes its own distinctiveness through its symbiosis, the museum constitutes itself as a space intertwined with external reality. This is particularly true in the case of South Asian museum artefacts: because of the concept ofdarśan(the sensuous relationship between the worshipper and the deity's material embodiment) curators have faced the challenge of coming to terms with visitors’ responses, from colonial to post-colonial times. A direct consequence of this challenge is represented by the reconstructions of religious spaces—shrines, altars, temples—that should evoke the so-called “original context” and be in consonance with local forms of material engagement.By adopting eco-phenomenology as its methodological framework, this article examines colonial sources, in particular the works of Thomas Hendley (1847–1917) and Fanny Parks (1794–1875), and compares them to the ethnographic fieldwork undertaken by the author at the Oriental Museum of the University of Durham in November 2014, as part of doctoral research.
Purchasing patterns in low-income neighbourhoods: implications for studying sugar-sweetened beverage taxes
Authors: Madsen Kristine A , Falbe Jennifer , Olgin Gabriella , Ibarra-Castro Ana , Rojas Nadia 
Published: March 2019

AbstractObjectiveThe present study aimed to determine the store types from which people in low-income neighbourhoods purchase most sugar-sweetened beverages (SSB) and to identify associations between purchasing location and demographic characteristics.DesignStreet-intercept surveys of passers-by near high foot-traffic intersections in 2016. Participants completed a beverage frequency questionnaire and identified the type of store (e.g. corner store, chain grocery) from which they purchased most SSB.SettingEight low-income neighbourhoods in four Bay Area cities, California, USA.ParticipantsSample of 1132 individuals who reported consuming SSB, aged 18–88 years, who identified as African-American (41 %), Latino (29 %), White (17 %) and Asian (6 %).ResultsBased on surveys in low-income neighbourhoods, corner stores were the primary source from which most SSB were purchased (28 %), followed by discount stores (18 %) and chain groceries (16 %). In fully adjusted models, those with lower education were more likely to purchase from corner stores or discount groceries than all other store types. Compared with White participants, African-Americans purchased more frequently from corner stores, discount groceries and chain groceries while Latinos purchased more frequently from discount groceries.ConclusionsThe wide range of store types from which SSB were purchased and demographic differences in purchasing patterns suggest that broader methodological approaches are needed to adequately capture the impact of SSB taxes and other interventions aimed at reducing SSB consumption, particularly in low-income neighbourhoods.
Reflector Selection for the Indexing of Electron Backscatter Diffraction Patterns
Authors: Wright Stuart I. , Singh Saransh , De Graef Marc 
Published: March 2019

AbstractWe propose a new methodology for ranking the reflectors used in traditional Hough-based indexing of electron backscatter diffraction (EBSD) patterns. Instead of kinematic X-ray or electron structure factors (Fhkl) currently utilized, we propose the integrated Kikuchi band intensity parameter (βhkl) based on integrated dynamical electron backscatter intensities. The proposed parameter is compared with the traditional kinematical intensity, $I_{hkl}^{{\rm kin}} $, as well as the average Hough transform peak intensity, $I_{hkl}^{{\rm HSP}} $ and used to index EBSD patterns for a number of different material systems of varying unit cell complexities including nickel, silicon, rutile, and forsterite. For elemental structures, βhkl closely follows the kinematical ranking. However, significant ranking differences arise for more complex unit cells, with the βhkl parameter showing a better correlation with the integrated Hough intensities. Finally, Hough-based indexing of a simulated forsterite data set showed an appreciable improvement in the median confidence index (0.15 to 0.35) when βhkl is used instead of $I_{hkl}^{{\rm kin}} $ for ranking the reflectors.
Malpractice litigation, workload, and general practitioner retirement
Authors: Birkeland Søren , Bogh Søren Bie 
Published: March 2019

AbstractWe investigated the association between general practitioner (GP) stress factors, including involvement in malpractice litigation or high workload levels during 2007 and ensuing retirement in a sample of Danish GPs. The case file and register information of 739 GPs were examined. Hazard ratios (HRs) were estimated for all causes of retirement from 2007 to 2016. During the study period, 34% of GPs had ceased to practice (n= 260). The HR for retirement was higher with increasing age (HR = 1.19 per year) and lower if practicing in a clinic with a greater number of GPs (HR = 0.47) but no statistically significant association was found between retirement and litigation or higher workload. Knowledge on factors influencing GPs’ decision on whether to continue working is important to ensure sustainable primary care provision.
On the Relative Strength of Electric and Magnetic ULF Wave Radial Diffusion During the March 2015 Geomagnetic Storm
Authors: Olifer L. , Mann I. R. , Ozeke L. G. , Rae I. J. , Morley S. K. 
Published: March 2019

AbstractIn this paper, we study electron radial diffusion coefficients derived from Pc4‐Pc5 ultralow frequency (ULF) wave power during the intense geomagnetic storm on 17–18 March 2015. During this storm the population of highly relativistic electrons was depleted within 2 hr of the storm commencement. This radial diffusion, depending upon the availability of source populations, can cause outward radial diffusion of particles and their loss to the magnetosheath, or inward transport and acceleration. Analysis of electromagnetic field measurements from Geostationary Operational Environment Satellite (GOES), Time History of Events and Macroscale Interactions during Substorms (THEMIS) satellite, and ground‐based magnetometers shows that the main phase storm‐specific radial diffusion coefficients do not correspond to statistical estimates. Specifically, during the main phase, the electric diffusion (
) is reduced, and the magnetic diffusion (
) is increased, compared to empirical models based on Kp. Contrary to prior results, the main phase magnetic radial diffusion cannot be neglected. The largest discrepancies, and periods of dominance of
over
, occur during intervals of strongly southward IMF. However, during storm recovery, both magnetic and electric diffusion rates are consistent with empirical estimates. We further verify observationally, for the first time, an energy coherence for both
and
where diffusion coefficients do not depend on energy. We show that, at least for this storm, properly characterizing main phase radial diffusion, potentially associated with enhanced ULF wave magnetopause shadowing losses, cannot be done with standard empirical models. Modifications, associated especially with southward IMF, which enhance the effects of
and introduce larger main phase outward transport losses, are needed.
Long noncoding RNAs: a missing link in osteoporosis
Authors: Silva Andreia Machado , Moura Sara Reis , Teixeira José Henrique , Barbosa Mário Adolfo , Santos Susana Gomes , Almeida Maria Inês 
Published: March 2019

AbstractOsteoporosis is a systemic disease that results in loss of bone density and increased fracture risk, particularly in the vertebrae and the hip. This condition and associated morbidity and mortality increase with population ageing. Long noncoding (lnc) RNAs are transcripts longer than 200 nucleotides that are not translated into proteins, but play important regulatory roles in transcriptional and post-transcriptional regulation. Their contribution to disease onset and development is increasingly recognized. Herein, we present an integrative revision on the studies that implicate lncRNAs in osteoporosis and that support their potential use as therapeutic tools. Firstly, current evidence on lncRNAs involvement in cellular and molecular mechanisms linked to osteoporosis and its major complication, fragility fractures, is reviewed. We analyze evidence of their roles in osteogenesis, osteoclastogenesis, and bone fracture healing events from human and animal model studies. Secondly, the potential of lncRNAs alterations at genetic and transcriptomic level are discussed as osteoporosis risk factors and as new circulating biomarkers for diagnosis. Finally, we conclude debating the possibilities, persisting difficulties, and future prospects of using lncRNAs in the treatment of osteoporosis.
Associations of non-high-density lipoprotein cholesterol, triglycerides and the total cholesterol/HDL-c ratio with arterial stiffness independent of low-density lipoprotein cholesterol in a Chinese population
Authors: Wen Jia , Huang Yun , Lu Yao , Yuan Hong 
Published: March 2019

AbstractSeveral lipid parameters are closely associated with residual cardiovascular risk. We aimed to confirm that in a range of low-density lipoprotein cholesterol (LDL-c) levels (from <70 mg/dl to ≥160 mg/dl), other lipid parameters, such as triglyceride (TG) level, non-high-density lipoprotein cholesterol (non-HDL-c) level, and the total cholesterol (TC)/HDL-c ratio, are still related to arterial stiffness, which is a recognized marker of atherosclerosis. In this cross-sectional study, we measured brachial-ankle pulse wave velocity (baPWV), as well as clinical and biochemical indices in 16,733 Chinese adult volunteers who underwent health check-ups from January 2014 to January 2015. Arterial stiffness was defined as the upper quartile of baPWV. We applied multivariable logistic regression models to examine the associations between lipid parameters and arterial stiffness. Both men and women with high baPWV were more likely to have an atherogenic lipid phenotype. Among participants with LDL-c <70 mg/dl, participants with non-HDL-c ≥100 mg/dl had a multivariable adjusted OR for arterial stiffness of 1.66 (1.11–2.50) compared to those with non-HDL-c <100 mg/dl; participants with TG ≥150 mg/dl had an OR of 2.44 (1.61–3.71) compared to those with TG <150 mg/dl; and participants with a TC/HDL-c ratio ≥4 had an OR of 1.74 (1.15–2.65) compared to those with a TC/HDL-c ratio <4. Similar results were observed at other LDL-c levels. We found that non-HDL-c, TG, and the TC/HDL-c ratio were consistently associated with arterial stiffness in a range of LDL-c levels, even when LDL-c was below 70 mg/dl. These lipid measures are related to residual cardiovascular risk, possibly due to their detrimental effects on vascular structure.
FBXW2 suppresses migration and invasion of lung cancer cells via promoting β-catenin ubiquitylation and degradation
Authors: Yang Fei , Xu Jie , Li Hua , Tan Mingjia , Xiong Xiufang , Sun Yi 
Published: March 2019

AbstractFBXW2 inhibits proliferation of lung cancer cells by targeting SKP2 for degradation. Whether and how FBXW2 regulates tumor invasion and metastasis is previously unknown. Here, we report that FBXW2 is an E3 ligase for β-catenin. FBXW2 binds to β-catenin upon EGF-AKT1-mediated phosphorylation on Ser552, and promotes its ubiquitylation and degradation. FBXW2 overexpression reduces β-catenin levels and protein half-life, whereas FBXW2 knockdown increases β-catenin levels, protein half-life and transcriptional activity. Functionally, FBXW2 overexpression inhibits migration and invasion by blocking transactivation of MMPs driven by β-catenin, whereas FXBW2 knockdown promotes migration, invasion and metastasis both in vitro and in vivo lung cancer models. In human lung cancer specimens, while FBXW2 levels are inversely correlated with β-catenin levels and lymph-node metastasis, lower FBXW2 coupled with higher β-catenin, predict a worse patient survival. Collectively, our study demonstrates that FBXW2 inhibits tumor migration, invasion and metastasis in lung cancer cells by targeting β-catenin for degradation.
Diagnosis of fusion genes using targeted RNA sequencing
Authors: Heyer Erin E. , Deveson Ira W. , Wooi Danson , Selinger Christina I. , Lyons Ruth J. , Hayes Vanessa M. , O’Toole Sandra A. , Ballinger Mandy L. , Gill Devinder , Thomas David M. , Mercer Tim R. , Blackburn James 
Published: March 2019

AbstractFusion genes are a major cause of cancer. Their rapid and accurate diagnosis can inform clinical action, but current molecular diagnostic assays are restricted in resolution and throughput. Here, we show that targeted RNA sequencing (RNAseq) can overcome these limitations. First, we establish that fusion gene detection with targeted RNAseq is both sensitive and quantitative by optimising laboratory and bioinformatic variables using spike-in standards and cell lines. Next, we analyse a clinical patient cohort and improve the overall fusion gene diagnostic rate from 63% with conventional approaches to 76% with targeted RNAseq while demonstrating high concordance for patient samples with previous diagnoses. Finally, we show that targeted RNAseq offers additional advantages by simultaneously measuring gene expression levels and profiling the immune-receptor repertoire. We anticipate that targeted RNAseq will improve clinical fusion gene detection, and its increasing use will provide a deeper understanding of fusion gene biology.