bluuebunny/crossref_metadata_2025_split huggingface dataset:
Facilitating Positive Psychosocial Outcomes in Craniofacial Team Care: Strategies for Medical Providers
Authors: Stock Nicola Marie , Marik Patricia , Magee Leanne , Aspinall Cassandra L. , Garcia Laura , Crerand Canice , Johns Alexis 
Published: August 2019

Objective: Psychosocial issues associated with craniofacial diagnoses and the ongoing burden of care can impact the quality of life of patients and families, as well as treatment adherence and outcomes. Utilizing available literature and clinical expertise across 6 centers, the present article summarizes key psychosocial issues for the benefit of nonmental health medical providers and offers suggestions as to how all members of craniofacial teams can promote positive psychosocial outcomes. Results: Family adjustment across developmental phases is outlined, with strategies to support adaptive parental coping. Teasing is a common concern in craniofacial populations and medical providers can promote coping and social skills, as well as link families to mental health services when needed. Academic issues are described, alongside suggestions for medical providers to assist families with school advocacy and ensure access to appropriate services within the school setting. Medical providers are key in preparing patients and families for surgery, including consideration of medical, social, and logistical supports and barriers. As craniofacial care spans infancy to adulthood, medical providers are instrumental in assisting patients and families to navigate treatment transition periods. In addition to ongoing clinical team assessments, medical providers may utilize screening measures to identify and track patient and family adjustment in multiple areas of team care. Conclusions: Multidisciplinary providers play an important role in supporting positive adjustment in patients affected by craniofacial conditions and their families.
Augmentation of Therapy for Combined Loss of Heterozygosity 1p and 16q in Favorable Histology Wilms Tumor: A Children’s Oncology Group AREN0532 and AREN0533 Study Report
Authors: Dix David B. , Fernandez Conrad V. , Chi Yueh-Yun , Mullen Elizabeth A. , Geller James I. , Gratias Eric J. , Khanna Geetika , Kalapurakal John A. , Perlman Elizabeth J. , Seibel Nita L. , Ehrlich Peter F. , Malogolowkin Marcio , Anderson James , Gastier-Foster Julie , Shamberger Robert C. , Kim Yeonil , Grundy Paul E. , Dome Jeffrey S. ,   on behalf of the AREN0532 and AREN0533 study committees
Published: August 2019

PURPOSE In National Wilms Tumor Study 5 (NWTS-5), tumor-specific combined loss of heterozygosity of chromosomes 1p and 16q (LOH1p/16q) was associated with adverse outcomes in patients with favorable histology Wilms tumor. The AREN0533/AREN0532 studies assessed whether augmenting therapy improved event-free survival (EFS) for these patients. Patients with stage I/II disease received regimen DD4A (vincristine, dactinomycin and doxorubicin) but no radiation therapy. Patients with stage III/IV disease received regimen M (vincristine, dactinomycin, and doxorubicin alternating with cyclophosphamide and etoposide) and radiation therapy. METHODS Patients were enrolled through the AREN03B2 Biology study between October 2006 and October 2013; all underwent central review of pathology, surgical reports, and imaging. Tumors were evaluated for LOH1p/16q by microsatellite testing. EFS and overall survival were compared using the log-rank test between NWTS-5 and current studies. RESULTS LOH1p/16q was detected in 49 of 1,147 evaluable patients with stage I/II disease (4.27%) enrolled in AREN03B2; 32 enrolled in AREN0532. LOH1p/16q was detected in 82 of 1,364 evaluable patients with stage III/IV disease (6.01%) in AREN03B2; 51 enrolled in AREN0533. Median follow-up for 83 eligible patients enrolled in AREN0532/0533 was 5.73 years (range, 2.84 to 9.63 years). The 4-year EFS for patients with stage I/II and stage III/IV disease with LOH1p/16 was 87.3% (95% CI, 75.1% to 99.5%) and 90.2% (95% CI, 81.8% to 98.6%), respectively. These results are improved compared with the NWTS-5 updated 4-year EFS of 68.8% for patients with stage I/II disease ( P = .042), and 61.3% for patients with stage III/IV disease ( P = .001), with trends toward improved 4-year overall survival. The most common grade 3 or higher nonhematologic toxicities with regimen M were febrile neutropenia (39.2%) and infections (21.6%). CONCLUSION Augmentation of therapy improved EFS for patients with favorable histology Wilms tumor and LOH1p/16q compared with the historical NWTS-5 comparison group, with an expected toxicity profile.
Phase II Study of Proton Beam Radiation Therapy for Patients With Breast Cancer Requiring Regional Nodal Irradiation
Authors: Jimenez Rachel B. , Hickey Shea , DePauw Nicolas , Yeap Beow Y. , Batin Estelle , Gadd Michelle A. , Specht Michelle , Isakoff Steven J. , Smith Barbara L. , Liao Eric C. , Colwell Amy S. , Ho Alice , Januzzi James L. , Passeri Jonathan , Neilan Tomas G. , Taghian Alphonse G. , Lu Hsiao-Ming , MacDonald Shannon M. 
Published: August 2019

PURPOSE To evaluate the safety and efficacy of proton beam radiation therapy (RT) for patients with breast cancer who require regional nodal irradiation. METHODS Patients with nonmetastatic breast cancer who required postoperative RT to the breast/chest wall and regional lymphatics and who were considered suboptimal candidates for conventional RT were eligible. The primary end point was the incidence of grade 3 or higher radiation pneumonitis (RP) or any grade 4 toxicity within 3 months of RT. Secondary end points were 5-year locoregional failure, overall survival, and acute and late toxicities per Common Terminology Criteria for Adverse Events (version 4.0). Strain echocardiography and cardiac biomarkers were obtained before and after RT to assess early cardiac changes. RESULTS Seventy patients completed RT between 2011 and 2016. Median follow-up was 55 months (range, 17 to 82 months). Of 69 evaluable patients, median age was 45 years (range, 24 to 70 years). Sixty-three patients (91%) had left-sided breast cancer, two had bilateral breast cancer, and five had right-sided breast cancer. Sixty-five (94%) had stage II to III breast cancer. Sixty-eight (99%) received systemic chemotherapy. Fifty (72%) underwent immediate reconstruction. Median dose to the chest wall/breast was 49.7 Gy (relative biological effectiveness) and to the internal mammary nodes, 48.8 Gy (relative biological effectiveness), which indicates comprehensive coverage. Among 62 surviving patients, the 5-year rates for locoregional failure and overall survival were 1.5% and 91%, respectively. One patient developed grade 2 RP, and none developed grade 3 RP. No grade 4 toxicities occurred. The unplanned surgical re-intervention rate at 5 years was 33%. No significant changes in echocardiography or cardiac biomarkers after RT were found. CONCLUSION Proton beam RT for breast cancer has low toxicity rates and similar rates of disease control compared with historical data of conventional RT. No early cardiac changes were observed, which paves the way for randomized studies to compare proton beam RT with standard RT.
Neoadjuvant Chemotherapy With Cisplatin and Gemcitabine Followed by Chemoradiation Versus Chemoradiation for Locally Advanced Cervical Cancer: A Randomized Phase II Trial
Authors: da Costa Samantha Cabral S. , Bonadio Renata Colombo , Gabrielli Flavia Carolina G. , Aranha Andrea S. , Dias Genta Maria Luiza N. , Miranda Vanessa C. , de Freitas Daniela , Abdo Filho Elias , Ferreira Patrícia A.O. , Machado Karime K. , Scaranti Mariana , Carvalho Heloísa de A. , Estevez-Diz Maria Del Pilar 
Published: August 2019

PURPOSE Although chemoradiation therapy (CRT) with cisplatin remains the standard treatment of patients with locally advanced cervical cancer (LACC), 40% of patients present with disease recurrence. Additional treatment strategies are required to improve outcomes. We conducted a trial to evaluate the efficacy and safety of neoadjuvant chemotherapy (NAC) with cisplatin and gemcitabine followed by CRT. METHODS In this phase II trial, patients with LACC (International Federation of Gynecology and Obstetrics stage IIB to IVA or with positive lymph nodes) were randomly assigned to three cycles of NAC with cisplatin and gemcitabine followed by standard CRT with weekly cisplatin plus pelvic radiotherapy or to standard CRT alone. The primary end point was 3-year progression-free survival (PFS). Secondary end points were response rate, 3-year locoregional control, 3-year overall survival (OS), safety, and quality of life. RESULTS From 107 patients enrolled in the trial, 55 were randomly assigned to the NAC arm and 52 to the CRT-alone arm. The majority of patients had squamous cell carcinoma (87.8%). After a median follow-up of 31.7 months, NAC was associated with an inferior PFS, with 3-year PFS rates of 40.9% v 60.4% in the CRT arm (hazard ratio, 1.84; 95% CI, 1.04 to 3.26; P = .033). NAC also was associated with a lower OS (3-year OS rate, 60.7% v 86.8%; hazard ratio, 2.79; 95% CI, 1.29 to 6.01; P = .006). After treatment completion, complete response rates were 56.3% in the NAC arm and 80.3% in the CRT arm ( P = .008). Toxicities were similar in both arms, with the exception of hypomagnesemia and neuropathy being more common with NAC. CONCLUSION This study shows that the addition of NAC consisting of cisplatin and gemcitabine to standard CRT is not superior and is possibly inferior to CRT alone for the treatment of LACC.
Leveraging the Outpatient Pharmacy to Reduce Medication Waste in Pediatric Asthma Hospitalizations
Authors: Hoefgen Erik R , Jones Yemisi , Courter Joshua , Hare Andrew , Garcia José A Torres , Simmons Jeffrey 
Published: August 2019

BACKGROUND AND OBJECTIVEPrevious local quality improvement focused on discharging patients with inhaled corticosteroids (ICS) “in‐hand” decreased healthcare reutilization after hospitalization for an asthma exacerbation. However, as a result of these new processes, some patients admitted for an asthma exacerbation received more than one ICS inhaler during their admission, contributing to medication waste and potential patient confusion regarding their discharge medication regimen. We sought to decrease this waste.METHODSWe conducted a quality improvement project to reduce the prescribing of multiple ICS inhalers to patients at a large academic children's hospital. Our primary outcome measure was the monthly percentage of patients admitted with an asthma exacerbation who were administered more than one ICS inhaler. A secondary outcome measure evaluated the reliability of the new process of using the hospital‐based outpatient pharmacy to supply ICS “in‐hand” and verify insurance coverage. After the process map review, we hypothesized a delay in the initial ICS treatment decision would allow for both a finalized discharge medication plan and a standardized process to verify outpatient insurance coverage.RESULTSThe mean percentage of patients receiving more than one ICS inhaler decreased from our baseline of 7.4% to 0.7%. Verification of outpatient prescription insurance coverage via the outpatient pharmacy increased from 0.7% to 50%. The average inpatient cost (average wholesale price) for ICS decreased by 62% to $90.25.CONCLUSIONSOur process change to use the outpatient pharmacy to dispense and verify insurance coverage for ICS medication was associated with a reduction in medication waste during admission for an asthma exacerbation.
Barriers to Providing VTE Chemoprophylaxis to Hospitalized Patients: A Nursing‐Focused Qualitative Evaluation
Authors: Kreutzer Lindsey , Yang Anthony D , Sansone Christina , Minami Christina , Saadat Lily , Bilimoria Karl Y , Johnson Julie K 
Published: August 2019

BACKGROUNDVenous thromboembolism (VTE) is a serious medical condition that results in preventable morbidity and mortality.OBJECTIVESThe objective of this study was to identify nursing‐related barriers to administration of VTE chemoprophylaxis to hospitalized patients.DESIGNThis was a qualitative study including nurses from five inpatient units at one hospital.METHODSObservations were conducted on five units to gain insight into the process for administering chemoprophylaxis. Focus group interviews were conducted with nurses and were audio‐recorded, transcribed verbatim, and analyzed using the Theoretical Domains Framework to identify barriers to providing VTE chemoprophylaxis.RESULTSWe conducted 14 focus group interviews with nurses from five inpatient units to assess nurses' perceptions of barriers to administration of VTE chemoprophylaxis. The barriers identified included nurses' misconceptions that ambulating patients did not require chemoprophylaxis, nurses' uncertainty when counseling patients on the importance of chemoprophylaxis, and a lack of comparative data for nurses regarding their specific refusal rates.CONCLUSIONSMultiple factors act as barriers to patients receiving VTE chemoprophylaxis. These barriers are often modifiable targets for quality improvement. There is a need to focus on behavior changes that will remove or minimize barriers and equip nurses to ensure administration of VTE chemoprophylaxis by engaging patients in their care.
Detection of Aflatoxin B1 in Pistachio Kernels Using Visible/Near-Infrared Hyperspectral Imaging
Authors: Wu Qifang , Xu Huirong 
Published: August 2019

Abstract. Pistachios are susceptible to aflatoxin contamination because of their rich nutrient content. Hyperspectral imaging (HSI), a new method for collecting spectral and image information, has been successfully employed in contamination research to classify staple agricultural products, such as maize, that are contaminated with aflatoxins. However, only a few studies have been conducted on the nondestructive discrimination among contaminated nuts using HSI for both qualitative and quantitative purposes. Thus, the feasibility of directly detecting aflatoxin B1 (AFB1) in individual pistachio kernels using visible/near-infrared HSI (VNIR HSI) was explored in this study. A total of 300 pistachio kernels were randomly selected to prepare target samples that were artificially contaminated with 5, 10, 20, 30, or 50 ppb (parts per billion) of AFB1. Principal component analysis (PCA) showed an overall separation trend between the control and all contaminated kernels. Accuracies greater than 90.0% were obtained by linear discriminant analysis (LDA) for samples that were artificially contaminated with different concentrations of AFB1 based on spectra at 694 to 988 nm that had been preprocessed with standard normal variate (SNV) and Savitzky-Golay (SG) smoothing. The correlation coefficients of calibration and validation (rc and rv) from stepwise multiple linear regression (SMLR) models were all &gt;0.9100. Moreover, five key wavelengths (708, 771, 892, 915, and 941 nm) closely associated with AFB1 contamination were identified using principal component spectra analysis. Generally, the results indicated that VNIR HSI could be employed for preliminary screening of pistachio kernels that were artificially contaminated with AFB1, even at the 5 ppb level. However, the quantitative prediction of the specific AFB1 concentration needed to be further improved. Keywords: Aflatoxins, Detection analysis, Hyperspectral information, Pistachios, Visible/near-infrared.
Inventory and exploration of orchid in Polewali Mandar, West Sulawesi, Indonesia
Authors: PUSPITANINGTYAS DWI MURTI 
Published: August 2019

Sulawesi is the fourth largest island in Indonesia. Sulawesi is also a very unique island, possessing a very high biodiversity due to the location on the Wallacea area, and constituting mixing plants from Asia and Australia. An inventory and exploration of orchid in Polewali Mandar Regency was conducted from 25 May to 13 June 2014 to determine and assess the orchid diversity in the area. Orchid specimens were recorded and collected using a purposive random sampling method. A total of 60 accession numbers were collected in the study area. These collections represent 22 genera and 51 species, consists of 41 epiphyte orchids species and 10 terrestrial orchids species. Some species are wide distribute in Indonesia, few of them are only found in eastern part of Indonesia such as Wallacea region, and are even endemic to Sulawesi. Luisia celebica Schltr. and Micropera sterrophylla (Schltr.) Garay are noted as endemic orchid to Sulawesi. While Dendrobium bicaudatum Reinw. ex Lindl., Habenaria beccarii Schltr., Malaxis trigonopetala (J.J.Sm.) S.Thomas, Schuit. & de Vogel and Pinalia quinquangularis (J.J.Sm.) Ormerod are endemic to the Wallacea region mainly in Sulawesi and Moluccas. Among those orchids found in the study, Dendrobium clavator Ridl., Pinalia quinquangularis (J.J.Sm.) Ormerod, and Pinalia xanthocheila (Ridl.) W.Suarez & Cootes are noted as new records in Sulawesi. Many new records of orchids are still to be expected from Sulawesi.
Rhizosphere fungal community, soil physicochemical properties, understorey vegetation and their relationship during post-coal mining reclamation in East Kalimantan, Indonesia
Authors: SUDRAJAT SUDRAJAT , WIDHAYASA BAYU , RUSDIANSYAH RUSDIANSYAH , SUSANTO DWI 
Published: August 2019

Abstract. Sudrajat, Widhayasa B, Rusdiansyah, Susanto D. 2019. Rhizosphere fungal community, soil physicochemical properties, understorey vegetation and their relationship during post-coal mining reclamation in East Kalimantan, Indonesia. Biodiversitas 20: 1953-1962. The objective of this study was to evaluate the composition of fungal community in rhizosphere, understorey vegetation and soil physicochemical properties post-coal mining reclamation. Soil sampling was conducted using a series of reclamation stages plots (undisturbed, disturbed, two, nine, twelves and sixteen years of reclamation) with drill ground at a depth of 0-30 cm. On each plot, five-point drilling was conducted; soil samples were composited; and their physicochemical properties including soil pH, organic carbon, total N, available P, available K, Ca, Mg, Fe, Mn, and S content were analyzed. Rhizosphere microfungi were isolated by using serial dilution and plated on potato dextrose agar added with Streptomycin. Identification and characterization of soil microfungi were done with the help of accessible manuals of fungi. The results showed that fungal genera at rhizosphere during post-coal mining reclamation were Aspergillus, Penicillium, Cephalosporium, Gliocladium, Humicola, Trichoderma, and Paecilomyces. Aspergillus was dominant comprising 74% of the total isolates. The fungal density in the undisturbed soil and the post-coal mining reclamation soil were higher than in the disturbed soil. The fungal rhizosphere groups isolated were saprophytic fungi that were present in a high relative density. In addition, the results showed that fungal rhizosphere was negatively correlated with soil pH and organic carbon. On the other hand, fungal rhizosphere was positively correlated with total N, available P, and available K. It can be concluded that the time period of post-coal mining reclamation, vegetation, and soil physicochemical profoundly determined the soil fungal community.
Socio-ecological perspective of local bio-resources based production system of palm sugar and palm flour from aren (Arenga pinnata): Case study of Sukaresmi Village, West Bandung, Indonesia
Authors: WITHANINGSIH SUSANTI , PARIKESIT PARIKESIT , ISKANDAR JOHAN , PUTRI RISYA 
Published: August 2019

Abstract. Withaningsih S, Parikesit, Iskandar J, Putri R. 2019. Socio-ecological perspective of local bio-resources based production system of palm sugar and palm flour from aren (Arenga pinnata): Case study of Sukaresmi Village, West Bandung, Indonesia. Biodiversitas. 20: 1990-1997. The heterogeneity of landscapes, from a socio-ecology viewpoint, has resulted in the emergence of various systems of production for the same end products, which have developed with wide variations and distinctiveness and are based on the local availability of bio-resources. Even on landscapes with extreme biophysical and social conditions, various systems of production can still be encountered. Bio-resource-based systems generally exist on a small scale and in poorly-resourced communities. This study aimed to determine the use of local bio-resources and palm management techniques in different systems used for the production of palm sugar and palm flour. This study utilized a combination of qualitative and quantitative methods. Primary data were collected using structured and semi-structured interviews, observations, and participants’ observations. The results showed that palm sugar was processed by peeling the midrib, passing, tapping, and making the midrib into sugar, whereas palm flour was processed by cutting down trees, grating, squeezing, and precipitating the end product. The local bio-resources used in the production of both included Chinese albizia (Albizia chinensis), giant bamboo (Dendrocalamus giganteus), tali bamboo (Gigantochloa apus), kemang (Mangifera kemanga), jackfruit (Artocarpus heterophyllus), and sobsi (Maesopsis eminii). Local knowledge regarding the processing of palm sugar was passed from generation to generation, whereas the knowledge regarding the processing of palm flour was achieved through independent learning and asking questions.
Fertility Intentions and Perspectives on Contraceptive Involvement Among Low‐Income Men Aged 25 to 55
Authors: Campbell Anthony D. , Turok David K. , White Kari 
Published: August 2019

CONTEXTUnintended pregnancy is disproportionately reported by low‐income individuals in the United States, and studies of men's roles in preventing pregnancy have largely focused on adolescents and young adults. Less is known about the pregnancy‐related attitudes and behaviors among men older than 24, who are involved in the majority of pregnancies ending in a birth.METHODSBetween December 2015 and August 2016, in‐depth interviews were conducted with 26 low‐income men in Alabama who were aged 25–55, were sexually active and did not want more children. Interviews explored men's reasons for not wanting more children, their contraceptive knowledge and attitudes, and their involvement in contraceptive decision making. Transcripts were examined using content analysis to identify themes related to men's perspectives about preventing pregnancy and using contraceptives.RESULTSParticipants' motivations to prevent a pregnancy centered primarily on their age and financial circumstances. Most men had limited contraceptive knowledge and perceived their risk of causing a pregnancy to be low, regardless of method use. Few men engaged in decisions about contraceptive use, despite their beliefs that men and women had a shared responsibility to prevent pregnancy. Although some men were interested in vasectomy, a few were hesitant about undergoing the procedure because they might want to have children later if their life circumstances changed, and others worried that vasectomy might affect sexual performance.CONCLUSIONSSome low‐income adult men were uncertain about their pregnancy desires, and many lacked contraceptive knowledge that would help them avoid unwanted pregnancy. Research is needed to identify the types of programs that could effectively promote men's constructive engagement in preventing pregnancies over their reproductive life course.