bluuebunny/crossref_metadata_2025_split huggingface dataset:
GPRC5b Modulates Inflammatory Response in Glomerular Diseases via NF-κB Pathway
Authors: Zambrano Sonia , Möller-Hackbarth Katja , Li Xidan , Rodriguez Patricia Q. , Charrin Emmanuelle , Schwarz Angelina , Nyström Jenny , Wernerson Annika Östman , Lal Mark , Patrakka Jaakko 
Published: July 2019

Significance Statement
Mechanisms regulating inflammatory response in glomeruli are poorly understood. In this study, the authors identify a novel G protein–coupled receptor (GPCR) that is highly enriched in podocytes, called Gprc5b. Gprc5b is upregulated in common human glomerular diseases, such as IgA nephropathy, lupus nephritis, and diabetic nephropathy. Studies in knockout animals and human podocytes grown in culture show that Gprc5b promotes glomerular inflammation via regulation of NF-κB pathway in podocytes. Upregulation of Gprc5b in human diseases suggests that this mechanism may play an important role in the pathogenesis of common glomerulopathies.

Background
Inflammatory processes play an important role in the pathogenesis of glomerulopathies. Finding novel ways to suppress glomerular inflammation may offer a new way to stop disease progression. However, the molecular mechanisms that initiate and drive inflammation in the glomerulus are still poorly understood.

Methods
We performed large-scale gene expression profiling of glomerulus-associated G protein–coupled receptors (GPCRs) to identify new potential therapeutic targets for glomerulopathies. The expression of Gprc5b in disease was analyzed using quantitative PCR and immunofluorescence, and by analyzing published microarray data sets. In vivo studies were carried out in a podocyte-specific Gprc5b knockout mouse line. Mechanistic studies were performed in cultured human podocytes.

Results
We identified an orphan GPCR, Gprc5b, as a novel gene highly enriched in podocytes that was significantly upregulated in common human glomerulopathies, including diabetic nephropathy, IgA nephropathy, and lupus nephritis. Similar upregulation of Gprc5b was detected in LPS-induced nephropathy in mice. Studies in podocyte-specific Gprc5b knockout mice showed that Gprc5b was not essential for normal development of the glomerular filtration barrier. However, knockout mice were partially protected from LPS-induced proteinuria and recruitment of inflammatory cells. Mechanistically, RNA sequencing in Gprc5b knockouts mice and experiments in cultured human podocytes showed that Gpr5cb regulated inflammatory response in podocytes via NF-κB signaling.

Conclusions
GPRC5b is a novel podocyte-specific receptor that regulates inflammatory response in the glomerulus by modulating the NF-κB signaling pathway. Upregulation of Gprc5b in human glomerulopathies suggests that it may play a role in their pathogenesis.
GÜVENLİK İKLİMİ ALGISININ DEMOGRAFİK FAKTÖRLERE GÖRE ALAN KURAMI BAĞLAMINDA İNCELENMESİ: İNŞAAT SEKTÖRÜNDE BİR UYGULAMA
Authors: Acar Pınar , Kılıç Samet 
Published: July 2019

Dünyanın birçok yerinde ve Türkiye’de, inşaat
sektöründe çalışan işgörenlerin güvenlik ve sağlığıyla ilgili sorunların
artması araştırmamızın sorunsalının temel odağını oluşturmuştur. İş sağlığı ve güvenliğinin örgüt içinde
kurulan değerler sistemiyle yakından ilişkili olmasından dolayı, bir iş yerinde
sadece kuralların yazılması ve uygulamaya konulması tek başına yeterli
olmamaktadır. Aynı zamanda tüm çalışanların ve yöneticilerin dahil olacağı bir
güven ikliminin tesis edilmesi ve bu iklimin örgüt kültürü ile uyumlu hale
getirilmesi oldukça önemlidir. Araştırmamızın temel varsayımı Kurt Lewin’in
Alan Teorisi ile desteklenmiştir. Bu çalışmada nicel araştırma yöntemi
kullanılmıştır. Konu kapsamında teorik çerçevenin çizilmesinin ardından 79
beyaz yakalı çalışan ile gerçekleştirilen uygulamada, katılımcıların demografik
özellikleri ile güvenlik iklimi algıları arasında bir ilişki olup olmadığı
sorgulanmıştır. Araştırmanın verileri SPSS 20 programı kullanılarak analiz
edilmiştir. Analizler sonucu ortaya çıkan bulgular, inşaat sektöründe görev
yapan çalışanların güvenlik iklimi algılarının, çalıştıkları sektöre ve pozisyonlarına
göre değişmekte olduğunu ortaya koymuştur.
The incidence detection of tuberculosis in patients with infertility and abnormal uterine bleed: a study in North Indian population
Authors: Kaur Simmanjit , Santpur Unmesh , Mor Sunita 
Published: July 2019

Background: Tuberculosis (TB) remains a major global health problem, responsible for ill health among millions of people each year. TB ranks as the second leading cause of death from an infectious disease worldwide, after the human immunodeficiency virus (HIV). The latest estimates included in this report are that there were 9.0 million new TB cases in 2013 and 1.5 million TB deaths (1.1 million among HIV-negative people and 0.4 million among HIV-positive people). In India the incidence of genital tuberculosis is nearly about 18%. And in female genital tract it is estimated that 18% in India suffer from genital TB.Methods: The study was carried-out during November 2014 to March 2016 at Maharishi Markandeshwar deemed to be University, MMIMSR Mullana (Ambala). A total of 100 females of reproductive age attending the Gynaecology Outpatient were finally recruited on the basis of inclusion and exclusion criteria.Results: In our study majority i.e. 39 (39.0%) patient were found in the group of 20-29 years of age followed by 38 (38.0%) patients in the group of 30-39 years of age. Only 23 (23.0%) were found in the group of 40-49 years of age. In our study majority i.e. 54 (54.0%) patients were from Haryana followed by 44 (44.0%) patients were from Uttar Pradesh and only 2 (2.0%) patients were from Punjab. Out of 100 patients majority i.e. 76 (76.0%) patients had negative TB with either of investigation and only 24 (24.0%) patients had positive TB with either of investigation.Conclusions: Female genital tuberculosis affects the females of reproductive age group. The disease manifests itself as pelvic inflammatory disease in its acute form with menstrual irregularities and later infertility, and is almost always secondary to a primary lesion elsewhere.
Chronic Chest Pain in Adolescents: Is Not Only a Medical Condition, But Also a Social Problem
Authors: KAYALİ Seyma , TEKİN Oguz 
Published: July 2019

Aim: Chest pain is a frequent cause of referral to
pediatric cardiology departments and leads to unnecessary testing although
cardiac etiology is very rare. Recent studies reported that adolescents’ chest pain is generally related with psychological disorder.
Adolescents prone to have psychological problems more than others. This
condition leads to have different social
trends which also can be affected from recurrent complaints and ilnesses. The
aim of this study is to examine the relationship between chest pain and social
trends in adolescents.Methods: A total of 101 adolescents -50 with chest
pain and 51 control- were enrolled in
this study and ‘Social Trends Scale (STS)’ was applied to all
participants. Cigarette smoking, presence of
family problem and monthly income were recorded. Social trends of participants
were evaluated in the subtitles of
social adaptation, substance avoidance, violence avoidance, school
status, family status and ‘target and ideals’ by ‘STS’ which included 26
questions. Results: Chest pain group had lower scores in all subtitles compared
with controls. Violence avoidance and family status scores were significantly
lower in study group. The presence of chest pain with smoking leaded to social
impairment and chest pain with smoking
decreased the substance avoidance behavior. Chest pain had negative
effect on school status with monthly income of the family.

Conclusion: Chest pain
effects some social trends negatively
with some other factors. This social situation which we have observed during
the evaluation of adolescents with chest
pain enlightens the importance of psychological evaluation and guidance
services.
The Relationship between Obesity and Cardiovascular Risk in Postmenopausal Women
Authors: ERTEN BUCAKTEPE Pakize Gamze , ÇELEPKOLU Tahsin , ASLAN İlknur , TANRIVERDİ M.halis , YILMAZ Ahmet , ASLANHAN Hamza , KARS Veysel 
Published: July 2019

Objective: The
aim of this study was to investigate the relationship between obesity and
cardiovascular risk in postmenopausal women.

Methods: The study included 43 postmenopausal women who were
admitted to Dicle University Medical School Family Medicine Outpatient Clinic in
2011. Body mass index (BMI), waist and hip circumferences, body fat mass and
percentage, 24-hour arterial tension measurements, homocysteine (Hcy) level,
vitamin B12 level, and Framingham risk score (FRS) were compared between obese
(BMI&gt;30 kg/m²) and non-obese (BMI≤30 kg/m²) patients.

Results: The patients included 24 (55.8%) obese and 19 (44.2%)
non-obese patients. Abdominal obesity was seen in 29 (67.4%) and truncal
obesity in 33 (76.7%) participants. Family history of cardiac disease was seen
in 25 (58.1%) women, most of whom were obese. Based on FRS, moderate
cardiovascular risk was assessed in 21.6%, but none of the participants were at
high risk. FRS was higher in patients with Hcy levels of ≥15 µmol/L. In
addition, the Hcy values increased with age and there was a negative
correlation between Hcy levels and vitamin B12 status (r=-0.322, p=0.035).

Conclusion: The results of this study indicate that age- and gender-dependent
differences must be taken into consideration for cardiovascular risk
assessments and postmenopausal women should be informed about obesity and
hypertension in order to improve their quality of life.Özet Amaç:
Bu çalışmada postmenopozal kadınlarda obesite ve kardiyovasküler risk
ilişkisinin incelenmesi amaçlanmıştır. Gereç-Yöntem: çalışmaya Dicle Üniversitesi Tıp Fakültesi Aile
Hekimliği Polikliniğine 2011 yılında başvuran 43 postmenopozal kadın dahil
edilmiştir. Beden kitle indeksi (BKİ), bel ve kalça çevresi, vücut yağ kitle ve
yüzdesi, 24-saatlik kan basıncı ölçümleri, homosistein (Hcy) düzeyi, vitamin
B12 düzeyi ve Framingham risk skorlaması (FRS) obez olan (BKİ&gt;30 kg/m²) ve obez olmayan (BKİ≤30
kg/m²) kadınlarda ölçülerek karşılaştırılmıştır.Bulgular: Kadınların
24’ü (%55.8) obez ve 19’u (%44.2) non-obezdi. Abdominal obezite 29 (%67.4),
trunkal obezite 33 (%76.7) hastada mevcuttu. Kardiyak hastalık aile öyküsü,
çoğu obez olan 25 (%58.1) kadında tespit edildi. FRS’ye göre orta düzeyde kardiyovasküler risk %21.6 oranında
saptanırken hiçbir kadın yüksek risk grubunda değildi. FRS, Hcy seviyesi ≥15
µmol/L olan kadınlarda daha yüksekti. Hcy seviyesi yaşla artmaktaydı ve Hcy ile
vitamin B12 arasında negative korelasyon mevcuttu (r=-0.322, p=0.035).Sonuç: Bu
çalışma kardiyovasküler risk değerlendirmesine yaş ve cinsiyete bağlı
farklılıkların göz önünde bulundurulması ve postmenopozal kadınların, yaşam
kalitelerini arttırmak için obezite ve hipertansiyon konusunda
bilgilendirilmeleri gerektiğini göstermektedir.

Anahtar Kelimeler: Obezite,
Homosistein, Vitamin B12, Kan
basıncı Monitorizasyonu, Framingham Risk Skorlaması.
Analysis of Bone Mineral Density and Hip Fracture in Geriatric Patients with Heart Failure
Authors: ARSLAN Arslan Kağan , TOLUNAY Hatice 
Published: July 2019

Objectives: Osteoporosis
defined by low Bone Mineral Density (BMD), is a progressive disease affecting
especially older adults. Hip fracture is the important result of osteoporosis. For the older adults, heart failure (HF) and
osteoporosis are two common chronic conditions that are gaining importance for
healthcare. The aim of this study is to evaluate bone mineral density and hip
fractures in geriatric aged patients with heart failure

Methods: We retrospectively analyzed 157 geriatric
patients with heart failure and 155 geriatric control subjects without any
cardiovascular disease and risk factors. All subjects underwent transthoracic
echocardiography, biochemical analysis, and bone DEXA study. Osteoporotic
fracture history and operation for fracture, list of current and prior use of
medications were obtained from each center’s medical recordings.

Results: Among the 157 patients, 45 (29%) had normal
BMD, 14 (9%) had osteopenia, and 98 (62%) had osteoporosis. In 155 control subjects,68 (44%) had normal
BMD, 12 (8%) had osteopenia, and 75 (46%) had osteoporosis (P=0.019). Sixteen
subjects (10.2%) in heart failure group and 6 subjects (3.9%) in controls had
hip fracture (p=0.029). Level of 25-hydroxyvitamin D was significantly lower in
heart failure than in controls (15.1±10.2 vs. 29.1±20.4 ng/ml; p&lt;0.001).

Conclusion: Patients with heart failure have a lower bone
mineral density, low vitamin D level and an increased rate of hip fractures.
These findings can be explained by shared risk factors and pathogenetic
mechanisms. Further prospective studies should be performed for evaluating the
role of heart failure in osteoporotic hip fractures.
Diş Hekimlerinin HIV/AIDS ve Oral Lezyonlar Hakkındaki Bilgi Düzeyi ve Tutumlarının Değerlendirilmesi
Authors: İNCE Nevin 
Published: July 2019

Amaç: İnsan
İmmün Yetmezlik Virüsü (HIV), bağışıklık sistem hücrelerini hedef alarak
enfeksiyon oluşturan ve enfeksiyon ilerlediğinde Edinilmiş İmmün Yetmezlik
Sendromuna (AIDS) neden olabilen bir virüstür. Bu çalışmanın amacı, Diş
Hekimlerinin HIV/AIDS hastalığının olası bulaş yolları, HIV’nin bulunabileceği
vücut sıvıları ve HIV/AIDS’in ağız içi belirtileri ile ilgili bilgi düzeylerini
saptamak, bilgiye ulaşım yollarını belirlemek, hastalara karşı tutum ve farkındalıklarını
değerlendirmektir.Gereç ve Yöntem: SurveyMonkey
anket sistemi ile 17 soruluk anket hazırlandı. Hazırlanmış olan link, Diş
hekimlerine mail, cep telefonu ve sosyal paylaşım üzerinden gönderilerek
yanıtlanması istendi. Anketi yanıtlayan 180 hekimin cevapları değerlendirildi. Bulgular:
Anketi cevaplayan Diş hekimlerinin %73'ü
kadın, %43’ü 31-40 yaş aralığında idi. HIV/AIDS hastalarının ağız lezyonları
hakkında bilgileri sorulduğunda %39,6'sı oral candidiazis olarak yanıtladı. HIV/AIDS
bilgi düzeyini ölçen sorularda; %28,4'ü HIV ve AIDS’in aynı tanım olmadığını %99’u
korunmasız cinsel ilişki, kan teması ve kesici delici aletlerle yaralanma ile bulaş
olduğunu bilmekteydi. Önemli bir oranda diş hekimi; idrar ve tükürük ile bardak, havlu gibi ortak
kullanılan malzemelerle de bulaştığını ifade etmişlerdi. HIV enfekte hasta ile
ilgili tutumları değerlendirildiğinde, katılımcıların yarısından fazlası
çekinmeden tedavi yaparım olarak yanıtlamıştı. Hastalardan kendilerine HIV
bulaşma endişesi olup olmadığı sorulduğunda, %40’ı evet yanıtını vermişlerdi. HIV/AIDS
hakkındaki bilgilerini en çok fakültede (%85) ve yazılı kaynaklardan (%56,1)
edindiğini ifade etmişlerdi. Diş hekimlerinin %73,3’ü HIV/AIDS ve oral
lezyonlar hakkında yeterli bilgiye sahip olmadıklarını ve bilgilerinin
güncellenmesini istediklerini belirtmişlerdi.

Sonuç: Çalışmamızda
diş hekimlerinin bilgi
düzeyinin genel olarak kabul edilebilir olmasına rağmen, HIV'in bulaş yolları
konusunda yanlış bilgi ve tutum olduğu görülmüştür. Mezuniyet sonrası sahada çalışan diş
hekimlerine yönelik bilgilerin güncellenmesinin önemli olduğu düşünülmüştür.
PENGARUH EKSPOR IMPOR TERHADAP TRANSAKSI BERJALAN INDONESIA SEBELUM DAN SESUDAH SUBPRIME MORTGAGE
Authors: Bagaskoro Mayong Noor 
Published: July 2019

This study is to determine the effect of exports and imports on the current account of Indonesia and comparison before and after the 2008’s subprime mortgage crisis. The analytical method used is mutiple regression and strcutural break test. The regression results show that exports have positive effect and imports have negative effect on current account of Indonesia. While the structural break test show that there are differences in the comparison effect of export and import on the current account of Indonesia in the before and after the crisis.
Amendements on Salinity and Water Retention of Sand Base Rootzone and Turfgrass Yield
Authors: Rahayu Rahayu , Mo Yang Geun , Soo Choi Joon 
Published: July 2019

This research was column pot experiment with turfgrass was Kentucky bluegrass (<em>Poa pratensis</em>) plant irrigated saline irrigation and the column soaked in saline water. Rootzone profile consisted of 20 cm using saline lake dredged up sand. The sand amendments of the root zone were soil, zeolite, bottom ash, and peat. The mixtures of topsoil were; 90% sand + 10% peat moss, 80% sand + 10% soil + 10 % bottom ash, 80% sand + 20% soil, 90% sand + 5% peat + 5% zeolite, and 80% sand + 20% bottom ash. Interruption layer with coarse sand with diameters over 2 mm of 20 cm and 10 cm loamy soil as the bottom layer of the column. The result showed that Kentucky bluegrass could grow in sand based growing media amended by peat, sandy loam soils, bottom ash and zeolite being irrigated by 2 dS m<sup>-1</sup> saline water. Sand-based growing media amended by peat resulted in the highest clipping weigh but showed the highest salt accumulations. Sand amended by bottom ash and applied gypsum decreased clipping weigh, decreased SAR and increased calcium (Ca) when compared to the soil + peat (SP). Sand amended by zeolite and gypsum decreased clipping weight, decreased sodium adsorption ratio (SAR) and higher Ca. Higher soil moisture retention of growing media promoted the growth of Kentucky bluegrass in spring, and lower moisture content promoted the growth in summer and fall season.
Risk-Oriented Characteristics of the Current Epidemiological Situation on West Nile Fever in the Astrakhan Region
Authors: Kovalevskaya A. A. , Vasil’kova O. L. , Agapov B. L. , Kouklev E. V. , Safronov V. A. , Shcherbakova S. A. , Nikeshina N. N. , Noskova L. N. , Arshba T. E. , Rudenko G. G. , Shishlonov A. M. 
Published: July 2019

Objective – risk-oriented assessment of the current epidemiological situation on West Nile fever in the Astrakhan Region.Materials and methods. Utilized were the data collected by the Astrakhan Plague Control Station, Rospotrebnadzor Administration in the Astrakhan Region, and A.M. Nichoga Regional Infectious Clinical Hospital. The key method of study was epidemiological analysis of West Nile fever incidence among the population of the Region during the period of 2000–2016. 145 case records were investigated.Results and discussion. Retrospective analysis provided for identification and featuring of the main categories of epidemiological risk of infection with West Nile fever in the Astrakhan Region in 2000–2016. It was established that men of 19 to 70 age range ( 82.1 %) are infected more often (95 out of 145 – 65 %). WNF infections in women occur among the same age group (75.8 %), and also among children aged below 6 years old (9.0 %). Analysis of the risk territories showed that the level of risk is high in one district, medium – in one district, low – in four districts, and very low – in six. When investigating the conditions of infection (risk factors) with WNF, it was determined that in the majority of cases (107 – 73.8 %) the risk factors were not specified. Out of those that were identified, one should pinpoint the bite of mosquito inside the households, basements, while fishing (16.3 %), as well as the bite, removal or squashing of a tick with unprotected hands (6.9 %). The period of the highest risk is from May to October with the maximum values of incidence in August (55.1 %).
Detection of Crimean-Congo Hemorrhagic Fever Virus Markers in Samples of Ixodes Ticks Collected in the Territory of the Republic of Guinea
Authors: Naydenova E. V. , Zakharov K. S. , Kartashov M. Yu. , Agafonov D. A. , Boiko A. V. , Kas’yan Zh. A. , Senichkina A. M. , Nikiforov K. A. , Oglodin E. G. , Shipovalov A. V. , Dubinina A. A. , Porshakov A. M. , Nourdine I. , Diallo M. G. , Nassour A. A. , Kourouma A. , Drame F. , Safronov V. A. , Lopatin A. A. , Boumbali S. , Kalivogui S. , Boiro M. Y. , Shcherbakova S. A. , Kutyrev V. V. 
Published: July 2019

Objectiveof the study. This work was carried out to identify markers (antigen and RNA) of CrimeanCongo hemorrhagic fever (CCHF) virus in samples from ticks, collected in all landscape-geographical areas of Guinea: Lower, Middle, Upper and Forest, to obtain up-to-date data on the distribution of the pathogen in the country.Materials and methods. Total of 4276 specimens of 8 species of ticks collected in 2016–2019 in the territory of the Republic of Guinea were studied, which were compiled into 1406 samples. Ectoparasites were collected from livestock animals, dogs, and small mammals. Viral antigen was detected using enzyme immunoassay (ELISA). The presence of RNA of the CCHF virus was determined by reverse transcription polymerase chain reaction (RT-PCR).Results and discussion. As a result of the studies, the antigen of the CCHF virus was detected in 21 samples (1.5 %), and RNA – in 37 (2.6 %). All samples, in which the viral antigen was detected, contained RNA of the CCHF virus. Positive results were obtained in samples from all geographical areas of the country. The main vectors and reservoirs of the pathogen in Guinea are ticks of the species Rh. sanguineus, Rh. geigyi, Rh. annulatus and Am. variegatum. The data obtained confirm the previously available information on the possibility of the pathogen circulation in this region and determine the need for further study of the spread of the CCHF virus in the territory of the Republic of Guinea.
Kontruksi Etika Maduraisme Dalam Kode Etik Akuntan Profesional: Internalisasi Nilai “Gaik Bintang” Dalam Etika Profesi Akuntan
Authors: Djasuli Mohamad 
Published: July 2019

<p><em>This article has objectives to concots values of madurese culture’s local wisdoms in order to build the concept of accounting profession’s code of ethics in Indonesia holitically. The main foundation of the holistic accounting profession’s code of ethics in Indonesia is the local wisdoms in which are taken from the madurese culture from the madura folk song entitled “Ghai’ Bintang”. Ghai’ Bintang lyrics are full with God’s value that is implemented in honesty value and this is one of the charasterics of madura people in their daily life. The holistic concept will be very important in this research as the foundation that will be internally fused in the building of the holisctic Indonesian Accountant Code of Ethics with the Ghai’ Bintang song. The Holistic approach is a way in a research in building new concept from the previous one. This research has produced the holisctic Indonesian Accountant Code of Ethics in which based on the values of knowledge principles, competence, defenselesness, grateful, and happiness. Those five principles must be covered with hinesty value as the spearhead of moral that has to be owned by each accountant. Those principles are part of the transformation of God Values that must be applied by every human being in the earth. Thus, this is also a responsibility for each accountant when they take action in their professional activities. Moreover, the implementation of Madura local culture ethical value may become a new foundation of the reformation of accounting profession’s code of ethics in Indonesia in this industry revolution era.</em><strong></strong></p>