bluuebunny/crossref_metadata_2025_split huggingface dataset:
Features of the pharmacological activity of polypeptide modulators on acid-sensitive ion channels in the experiment
Authors: Dyachenko Igor A. , Murashev Arkadii N. 
Published: June 2019

Introduction: TRPV1 receptors play a significant physiological role. To study pharmacological activity of new agonists and antagonists is important for the development of new drugs. This paper reports on the features of polypeptide antagonists of TRPV1 based on in vivo data.
Materials and methods: The study was performed on 250 mature white ICR male mice weighing 25–30 g. Tests were conducted to evaluate the pharmacological activity and biological properties of APHC1-3 and a hybrid polypeptide A13 in thermal pain,, inflammation and body temperature tests.
Results and discussion: APHC1-3 polypeptides showed significant antinociceptive and analgesic activity in the dose range of 0.01–0.1 mg/kg, without causing hyperthermia. A single substitution of the aspartic acid residue of АРНС1 polypeptide at position 23 by transferring one asparagine residue from the cognate peptide АРНС3 led to a significant change in the properties of the molecule. A new polypeptide A13 did not alter the thermal sensitivity of the mice, but showed the most significant analgesic activity in the acid-induced pain model, unlike АРНС1. A13 inhibits TRPV1 and affects body temperature as a classic antagonist of this receptor.
Conclusion: Antagonistic properties of A13 became different from the properties of both initial analgesic polypeptides. Polypeptides APHC1-3 can be referred to as a new class of modulators of TRPV1, which produce a pronounced analgesic effect without hyperthermia.
“Brushed by the Wing of a Great Feeling”: The Embodied Mind inMy Ántonia
Authors: Doležal Joshua 
Published: June 2019

AbstractIn a famous scene from My Ántonia, Jim Burden sits studying Virgil's Georgics when Lena Lingard pays him a visit. He has been contemplating a lecture by his Latin professor from the day before, when he felt “brushed by the wing of a great feeling,” and his window is open to the “earthy wind” of a spring thaw, which makes him indolent. As Jim turns back to the page he is flooded by the warmth Lena has left behind, which sparks a fresh understanding of Virgil's phrase, “The best days are the first to flee.” This scene and others like it in My Ántonia reveal the body's ineluctable role in cognition. As Mark Johnson explains in The Meaning of the Body, abstract processes like thought, reasoning, and comprehension are driven by the felt qualities of situations. Thus, the physical particulars of Jim's meditation on Virgil are more than the objective correlative of mood; they saturate the situation that Jim experiences and define his understanding of it. Cather's representation of Jim's cognitive processes as a character and as a narrator resonates with developments in neuroscience and philosophy of mind which present the mind as the body.
Veel potentie voor zakelijke mediation
Authors: Schonewille Manon , Simon Thomas Marc 
Published: June 2019

Much potential for commercial mediation
The report ‘ZAM/ACB research on possibilities and impediments for commercial mediation’ of the Utrecht Montaigne Centre represents the most important results for the three target groups (lawyers, firms, and judges), with an accent on how users of commercial mediation in the Netherlands think about the potential of mediation.
Fundamentos de diseño de un entorno tecnológico para el estudio de las habilidades en resolución de problemas en primeras edades escolares
Authors: Diago Pascual D. , González-Calero José A. , Arnau David 
Published: June 2019

En este trabajo se presentan los fundamentos de diseño de un softwarecapaz de monitorizar y registrar datos referentes a la gestión de procesos de resolución de problemas matemáticos. El softwarepermite una recogida sistemática de las variables del proceso de resolución a partir de las cuales es posible obtener diferentes métricas de aprendizaje del estudiante. Al no centrar la atención exclusivamente en el resultado final del proceso de resolución, es posible identificar tendencias cognitivas de los estudiantes. En este manuscrito describimos las características de este entorno tecnológico junto con la base didáctica que justifica el interés de la investigación en niveles escolares en los que el escaso conocimiento limita la formalización de situaciones de resolución de problemas. Se adjuntan los primeros resultados de un estudio piloto que ha permitido evaluar fortalezas y debilidades de la versión en desarrollo. Finalmente, se discute sobre futuras direcciones para este entorno tecnológico como un paso más tanto en innovación como en investigación en Educación Matemática.
Evaluation of extracellular polymeric substances extracted from waste activated sludge as a renewable corrosion inhibitor
Authors: Go Liew Chien , Holmes William , Depan Dilip , Hernandez Rafael 
Published: June 2019

Background
Waste activated sludge (WAS) has recently gained attention as a feedstock for resource recovery. The aim of this study is to investigate the corrosion inhibition efficiencies of extracellular polymeric substances (EPS) extracted from WAS.

Methods
The studied corrosion inhibitors were tested with carbon steel in 3.64% NaCl saturated with CO2 at 25 °C, which is the typical oilfield environment. They were first prepared by EPS extraction (heating at 80 °C), followed by centrifugation for solid and liquid separation, then the supernatant was freeze-thawed five times for sterilization of microorganisms in WAS to terminate metabolic activities in the test inhibitors to ensure consistency in corrosion inhibition. The EPS mixture (supernatant) was then deemed as the test corrosion inhibitor. The inhibition performance was determined using potentiodynamic polarization scans.

Results
Waste activated sludge alone showed unsatisfactory inhibition. However, EPS extracted from WAS showed an optimum inhibition of approximately 80% with 1,000 mg/L of inhibitor. The average total solid (TS) and EPS contents of the WAS were 7,330 mg TS/L WAS and 110 mg EPS/g TS, respectively. Three sets of extracted EPS were scanned with fourier-transform infrared spectroscopy (FTIR) and showed almost overlapping curves, yielding the consistent inhibition performance.

Discussion
The potentiodynamic polarization results indicated that EPS acts as a mixed-type inhibitor which inhibits corrosion on both anode and cathode sites of metal surfaces. Based on the FTIR results, it was assumed that major chemical groups O–H, N–H, C–N, C=O, and C–H contributed to the inhibition by adsorbing on the metal surface, forming a biofilm that acts as a protective barrier to isolate the metal from its corrosive environment. Results show that WAS EPS corrosion inhibitors have inhibition performance comparable to commercial products, signifying their potential in commercialization. This corrosion inhibitor is renewable, biodegradable, non-toxic, and free from heavy metal, making it a superior green corrosion inhibitor candidate. Additionally, turning biomass into value-added product can be beneficial to the environment and, in this case, deriving new materials from WAS could also transform the economics of wastewater treatment operations.
Ontology negotiation: Knowledge interchange between distributed ontologies through agent negotiation
Authors: Zhu Junwu , Teng Ling , Lu Huimin , Shi Jieke , Li Bin 
Published: June 2019

SummaryWith the proliferation of knowledge source on the internet as well as the widely professional agents, the knowledge interchange is drawing much attention. Ontology is recognized as the crucial technology due to their nature of sharing, formalization, and conceptualization to integrate and share the knowledge. In this paper, by interpreting and negotiating the communication content, a unified understanding of knowledge is formed; then, we can realize the interoperability between ontologies. We have developed the ontology automatic negotiation by agent elect protocol (AEP) to elect optimal participants and encourage agents to obey the protocol, concept mapping protocol (CMP) to find the corresponding concept mappings with the highest relevancy, and in addition, agent negotiation protocol (ANP). In ANP, we define the simultaneous negotiation protocol and agents' strategies to combine distributed ontologies interchange with agent negotiation. Finally, the implementation and preliminary results are given to verify the validity of the proposed ontology negotiation.
Searching source code fragments using incremental clustering
Authors: Ďuračík Michal , Kršák Emil , Hrkút Patrik 
Published: June 2019

SummaryPlagiarism is becoming an increasingly serious problem in academic environment. In this paper, we deal with a specific kind of plagiarism: source code plagiarism. In this case, there is no software available for detecting plagiarism on a larger scale (hundreds of student submissions every year). We propose algorithms for source code parsing and processing as a part of a complex system for plagiarism detection. A source code vectorization using characteristic vectors is a vital piece of the whole process, and k‐means algorithm helps with the classification and clustering of vectors. Student assignments are submitted regularly, and any plagiarism detection system needs to handle them as they come. For this reason, we propose a modified incremental k‐means algorithm and a method for determining the number of clusters. We also consider methods for vector search among clusters and suggest the use of conditional entropy to select the important vector elements used in the search algorithm. Our results show how the proposed algorithms and methods work on real student submissions.
Chimeric antigen receptors designed to overcome transforming growth factor‐β‐mediated repression in the adoptive T‐cell therapy of solid tumors
Authors: Hartley Jordan , Abken Hinrich 
Published: June 2019

AbstractAdoptive cell therapy with chimeric antigen receptor (CAR)‐engineered T cells produced lasting remissions in the treatment of advanced, so far refractory B‐cell malignancies; however, the elimination of solid tumors remains so far elusive. The low efficacy of CAR T cells is thought to be due to the immune‐repressive milieu within the tumor lesion, predominantly mediated by transforming growth factor‐β (TGF‐β) that represses effector T‐cell activities and drives differentiation towards regulatory T cells (Tregs). Seeking to boost antitumor immunity, TGF‐β is currently targeted by different means in pre‐clinical studies. While a recent clinical trial showed the utility of shielding CAR T cells from TGF‐β repression, further strategies in counteracting TGF‐β in the adoptive cell therapy warrant exploration. We here discuss the most recent advances in the field and draw future developments to make CAR T‐cell therapy more potent in the treatment of solid cancer.
Mu‐KRAS attenuates Hippo signaling pathway through PKCι to sustain the growth of pancreatic cancer
Authors: Wang Peipei , Zhang Hongmei , Yang Jinhe , Li Zongxian , Wang Yiren , Leng Xiaohong , Ganapathy Suthakar , Isakson Pauline , Chen Changyan , Zhu Tongbo 
Published: June 2019

AbstractThe atypical protein kinase C isoform ι (PKCι) is upregulated, which cooperates with mutated KRAS (mu‐KRAS) to promote the development of pancreatic cancers. However, the exact role of PKCι in KRAS‐mediated pancreatic tumorigenesis is not fully defined. In the present study, we demonstrate that mu‐KRAS upregulates and activates PKCι, accompanied by dephosphorylation of large tumor suppressor (LATS), a key member of the growth‐inhibiting Hippo signaling pathway. As a result, Yes‐associated protein 1 (YAP1; a transcriptional coactivator) is dephosphorylated and translocates to the nucleus, which promotes transcription of downstream target genes to sustain the transformed growth of pancreatic cancer cells. In contrast, when PKCι is suppressed by the chemical inhibitor or small‐hairpin RNA, the levels of phosphorylated LATS and YAP1 are elevated and YAP1 is excluded from the nucleus, which enhances the susceptibility of pancreatic cancer cells harboring mu‐KRAS to apoptosis. These findings shed new light on the mechanisms underlying the pancreatic tumorigenesis initiated by mu‐KRAS, and suggest that the PKCι‐YAP1 signaling may potentially be therapeutically targeted for restricting the growth and inducing apoptosis in pancreatic tumors expressing mu‐KRAS.
High incidence of rhinovirus infection in children with community‐acquired pneumonia from a city in the Brazilian pre‐Amazon region
Authors: Ferreira Hivylla L. dos Santos , Costa Karla Luana P. , Cariolano Marilha S. , Oliveira Gustavo S. , Felipe Karen K. P. , Silva Elen S. A. , Alves Matheus S. , Maramaldo Carlos Eduardo C. , de Sousa Eduardo M. , Rego Joseany S. , Silva Ilana C. P. A. , Albuquerque Rejane K. S. , Araújo Nathalya S. C. , Amorim Angela M. M. , Costa Luciane D. , Pinheiro Claudiana S. , Guimarães Vinícius A. , Santos Mirleide C. , Mello Wyller A. , Falcai Angela , Lima‐Neto Lidio Gonçalves 
Published: June 2019

AbstractCommunity‐acquired pneumonia (CAP) is the leading cause of child death worldwide. Viruses are the most common pathogens associated with CAP in children, but their incidence varies greatly. This study investigated the presence of respiratory syncytial virus (RSV), adenovirus, human rhinovirus (HRV), human metapneumovirus (HMPV), human coronavirus (HCoV‐OC43 and HCoV‐NL63), and influenza A virus (FluA) in children with CAP and the contributing risk factors. Here, children with acute respiratory infections were screened by pediatrics; and a total of 150 radiographically‐confirmed CAP patients (aged 3 months to 10 years) from two clinical centers in Sao Luis, Brazil were recruited. Patient's clinical and epidemiological data were recorded. Nasopharyngeal swab and tracheal aspirate samples were collected to extract viral nucleic acid. RSV, adenovirus, rhinovirus, FluA, HMPV, HCoV‐OC43, and HCoV‐NL63 were detected by real‐time polymerase chain reaction. The severe CAP was associated with ages between 3 and 12 months. Viruses were detected in 43% of CAP patients. Rhinovirus infections were the most frequently identified (68%). RSV, adenovirus, FluA, and coinfections were identified in 14%, 14%, 5%, and 15% of children with viral infection, respectively. Rhinovirus was associated with nonsevere CAP (P = .014); RSV, FluA, and coinfections were associated with severe CAP (P < .05). New strategies for prevention and treatment of viral respiratory infections, mainly rhinovirus and RSV infections, are necessary.
Occurrence and distribution of organic and inorganic pollutants in groundwater
Authors: Kurwadkar Sudarshan 
Published: June 2019

AbstractDepletion of groundwater resources and continued decline in overall groundwater quality is a cause of concern because large human population around the world uses groundwater as a source of drinking water. This paper presents a comprehensive review of studies published in the year 2018 that documented issues of groundwater pollution, sources, and distribution reported from across the world due to anthropogenic, hydroclimatogical, and natural processes. Groundwater pollution due to organic contaminants focuses particularly on pesticides, herbicides, and contaminants of emerging concern. Pollution due to inorganic pollutants such as arsenic and other heavy metals is also reviewed with particular emphasis on regions that have reported a significantly higher incidence of these pollutants in groundwater. A compilation of various studies is also included in the review paper that showed increased incidences of waterborne illnesses due to fecal and microbial contamination due to poor sanitary practices. Reviews of groundwater contaminants such as fluoride and nitrate are included to provide readers a holistic understanding of groundwater pollution problem around the world.Practitioner points

Groundwater pollution issues during 2018 are reviewed and documented.

Occurrence of organic and inorganic pollutants in groundwater is reported.

Groundwater pollution vulnerability remains a critical issue.
Up to 80 Gbaud DP‐16QAM operation using InP‐based high‐bandwidth coherent driver modulator
Authors: Ozaki J. , Ogiso Y. , Hashizume Y. , Kanazawa S. , Ueda Y. , Nunoya N. , Tanobe H. , Ishikawa M. 
Published: June 2019

The authors obtained very good back‐to‐back bit error rate performance in up to 80 Gbaud DP‐16QAM operation by using their coherent driver modulator of a 3‐dB electro‐optic bandwidth of over 50 GHz. To achieve high bandwidth and good signal integrity, they used double ultra‐low loop wires between the driver IC and the modulator and a differential capacitively loaded travelling‐wave RF electrode based on straight coupled coplanar waveguide with a ground‐signal–signal‐ground configuration for their InP modulator. As far as they know, this is the highest bandwidth and baud rate operation so far for the high‐bandwidth coherent driver modulator configuration.
Predictors for Residual Pulmonary Vascular Obstruction after Unprovoked Pulmonary Embolism: Implications for Clinical Practice—The PADIS-PE Trial
Authors: Raj Leela , Robin Philippe , Le Mao Raphael , Presles Emilie , Tromeur Cécile , Sanchez Olivier , Pernod Gilles , Bertoletti Laurent , Jego Patrick , Leven Florent , Lemarié Catherine A. , Martin Aurore , Planquette Benjamin , Le Roux Pierre-Yves , Salaun Pierre-Yves , Nonent Michel , Girard Philippe , Lacut Karine , Melac Solen , Mismetti Patrick , Laporte Silvy , Meyer Guy , Leroyer Christophe , Couturaud Francis ,   for the PADIS-PE Investigators
Published: June 2019

Background We aimed to identify risk factors for residual pulmonary vascular obstruction after a first unprovoked pulmonary embolism (PE).
Methods Analyses were based on data from the double-blind randomized “PADIS-PE” trial that included 371 patients with a first unprovoked PE initially treated during 6 uninterrupted months; all patients underwent baseline ventilation–perfusion lung scanning at inclusion (i.e., after 6 months of anticoagulation). Each patient's pulmonary vascular obstruction indexes (PVOIs) at PE diagnosis and at inclusion were centrally assessed.
Results Among the 371 included patients, residual PVOI was available in 356 patients, and 150 (42.1%) patients had PVOI ≥ 5%. At multivariable analysis, age > 65 years (odds ratio [OR], 2.81, 95% confidence interval [CI], 1.58–5.00), PVOI ≥ 25% at PE diagnosis (OR, 3.53, 95% CI, 1.94–6.41), elevated factor VIII (OR, 3.89, 95% CI, 1.41–10.8), and chronic respiratory disease (OR, 2.18, 95% CI, 1.11–4.26) were independent predictors for residual PVOI ≥ 5%. Patients with ≥ 1 of these factors represented 94.5% (123 patients) of all patients with residual PVOI ≥ 5%.
Conclusion Six months after a first unprovoked PE, age > 65 years, PVOI ≥ 25% at PE diagnosis, elevated factor VIII, or chronic respiratory disease were found to be independent predictors for residual pulmonary vascular obstruction.
Clinical Trials Registration URL: http://www.controlled-trials.com. Unique identifier: NCT00740883.
Risk Factors for Major Bleeding during Prolonged Anticoagulation Therapy in Patients with Venous Thromboembolism: From the COMMAND VTE Registry
Authors: Kim Kitae , Yamashita Yugo , Morimoto Takeshi , Kitai Takeshi , Yamane Takafumi , Ehara Natsuhiko , Kinoshita Makoto , Kaji Shuichiro , Amano Hidewo , Takase Toru , Hiramori Seiichi , Oi Maki , Akao Masaharu , Kobayashi Yohei , Toyofuku Mamoru , Izumi Toshiaki , Tada Tomohisa , Chen Po-Min , Murata Koichiro , Tsuyuki Yoshiaki , Saga Syunsuke , Sasa Tomoki , Sakamoto Jiro , Kinoshita Minako , Togi Kiyonori , Mabuchi Hiroshi , Takabayashi Kensuke , Shiomi Hiroki , Kato Takao , Makiyama Takeru , Ono Koh , Furukawa Yutaka , Kimura Takeshi ,   On behalf of the COMMAND VTE Registry Investigators
Published: June 2019

Background There are limited data assessing the risk for bleeding on anticoagulation therapy beyond the acute phase in patients with venous thromboembolism (VTE). The present study aimed to identify risk factors for major bleeding during prolonged anticoagulation therapy in VTE patients.
Patients and Methods The COMMAND VTE Registry is a multicenter registry enrolling 3,027 consecutive patients with acute symptomatic VTE. The current study population consisted of 2,728 patients who received anticoagulation therapy beyond the acute phase, after excluding those patients with major bleeding events (n = 48), death (n = 66), or loss to follow-up (n = 32) during the initial parenteral anticoagulation period within 10 days after diagnosis, and those without anticoagulation therapy beyond 10 days after diagnosis (n = 153).
Results During the median follow-up period of 555 days, major bleeding occurred in 189 patients (70 patients within 3 months; 119 patients beyond 3 months) with fatal bleeding in 24 patients (13%). The cumulative incidence of major bleeding was 2.7% at 3 months, 5.2% at 1 year, and 11.8% at 5 years. Active cancer (hazard ratio [HR], 3.06, 95% confidence interval [CI], 2.23–4.18), previous major bleeding (HR, 2.38, 95% CI, 1.51–3.59), anemia (HR, 1.75, 95% CI, 1.27–2.43), thrombocytopenia (HR, 2.11, 95% CI, 1.27–3.33), and age ≥75 years (HR, 1.64, 95% CI, 1.22–2.20) were independently associated with an increased risk for major bleeding by the multivariable Cox regression model.
Conclusion Major bleeding events were not uncommon during prolonged anticoagulation therapy in real-world VTE patients. Active cancer, previous major bleeding, anemia, thrombocytopenia, and old age were the independent risk factors for major bleeding.
Interventional Radiology-Guided Procedures in the Treatment of Pediatric Solid Tumors: A Systematic Review and Meta-Analysis
Authors: Zambaiti Elisa , Siles Hinojosa Alexander , Montano Valentina , Mutanen Annika , Glenisson Mathilde , Sarnacki Sabine , Franchi Abella Stephanie , Pariente Daniele , Pio Luca 
Published: June 2019

Introduction The use of interventional radiology (IR) in the treatment of pediatric solid tumors has markedly increased over the last three decades. However, data on effectiveness of IR-techniques, such as embolization/ablation, are scarce. In this systematic review and meta-analysis, we examined the outcomes of IR-procedures in the treatment of solid tumors in children.
Materials and Methods Using a defined search strategy, we searched for studies reporting the use of IR-techniques for pediatric solid tumors from 1980 to 2017. Reports with less than three patients, review, and opinion articles were excluded. The study was conducted under preferred reporting items for systematic reviews and meta-analyses (PRISMA) guidelines. We analyzed dichotomous and continuous variables by appropriate statistical methods.
Results Of 567 articles screened, 21 papers met the inclusion criteria (12 retrospective, 7 prospective, and 2 randomized-control trials). Many of the analyzed papers described relatively small cohorts of patients. IR-guided procedures were mainly rescue procedures to treat primarily unresectable tumors, local recurrences, or metastases. Inclusion/exclusion criteria and success definition were not specified in most reports. Major side effects were documented in 17/286 (6%) infants, while minor side effects were self-limiting in most patients. Six studies had a comparison between tumor embolization (127 infants) to surgery or chemotherapy without IR-procedures (113 controls). The meta-analysis showed lower mortality (16 vs. 47%) and surgical time for resection (206 vs. 250 m), higher 2-year tumor-free survival (82 vs. 36%), and favorable histology in IR group (p < 0.001 for all).
Conclusion IR-guided techniques are promising in the treatment of pediatric solid tumors. Further prospective (randomized) trials are needed to clarify efficacy.