bluuebunny/crossref_metadata_2025_split huggingface dataset:
Urban background noise affects breeding song frequency and syllable-type composition in the Northern Mockingbird
Authors: Walters Mitchell J , Guralnick Robert P , Kleist Nathan J , Robinson Scott K 
Published: July 2019

AbstractThe Northern Mockingbird (Mimus polyglottos) is a successful urban adaptor known to display flexibility in foraging, nesting, and anti-predator behavior. Its vocal behavior is also complex, with a breeding song composed of a wide variety of non-mimetic and mimetic elements, or “syllable types.” We tested the hypothesis that Northern Mockingbird adaptation to urban settings includes changes in its vocal behavior in noisy urban environments. We studied an urban/suburban mockingbird population to test the effect of urban background noise on breeding song frequency and syllable-type composition. Given that urban noise overlaps most strongly with low-frequency vocalizations, a phenomenon known as “signal masking,” we predicted a positive association between noise levels and mockingbird average peak frequency (a measure of vocalization power). We further predicted a positive effect of noise levels on the peak frequency of the lowest-pitched syllable type in a mockingbird’s song, no effect on the peak frequency of the highest-pitched syllable type, and thus a negative effect on mockingbird peak frequency range. Lastly, we predicted a negative effect of background noise on the use of syllable types experiencing heavy signal masking and, conversely, a positive effect on the use of syllable types experiencing minimal signal masking. We found a significant positive effect of noise levels on both average peak frequency and peak frequency of the lowest-pitched syllable type, but no effect on the peak frequency of the highest-pitched syllable type and peak frequency range. In addition, as background noise levels increased, we found significant declines in the percentages of heavily masked syllable types (1–3 kHz) and significant increases in the percentages of syllable types in the 3–5 kHz range; percentages of syllable types >5 kHz were, however, unaffected by background noise. These results were consistent with the hypothesis that Northern Mockingbird breeding songs change in pitch and syllable-type composition in noisy settings, providing further evidence that songs of urban-adapting species differ in noisy environments.
Large-scale tree mortality from Rapid Ohia Death negatively influences avifauna in lower Puna, Hawaii Island, USA
Authors: Camp Richard J , LaPointe Dennis A , Hart Patrick J , Sedgwick Daniel E , Canale Lisa K 
Published: July 2019

Abstract‘Ōhi’a lehua (Metrosideros polymorpha) is the principle tree species in forests across the Hawaiian Islands and provides critical foraging and nesting habitat for native passerines. Rapid Ohia Death (ROD), caused by the vascular wilt fungus Ceratocystis lukuohia and the canker pathogen C. huliohia, was first detected in the Puna District of Hawaii Island in 2010. It affects all life stages of ‘ōhi’a and as of July 2018 had spread to an estimated 40,469 ha across Hawaii Island. To determine the impact of ROD on the forest bird community we conducted point counts in lowland ‘ōhi’a forest in 2016 and compared them to counts from 2003 to 2004, before the appearance of ROD. We found an increase in species diversity and a significant decrease in the densities of a native Hawaiian honeycreeper, the Hawaii Amakihi (Chlorodrepanus virens), and the nonnative Japanese White-eye (Zosterops japonicus). Yellow-fronted Canary (Crithagra mozambica) and Saffron Finch (Sicalis flaveola), 2 nonnative passerines associated with the shrub layer and more open habitats, were only detected in 2016. Proportion of survey points occupied were comparable between survey periods, but relative abundances were generally lower. Hawaii Amakihi densities declined by 79% and Japanese White-eye densities declined by 33%. Our findings suggest that the loss of ‘ōhi’a canopy due primarily to ROD has adversely affected populations of native Hawaii Amakihi and nonnative Japanese White-eye, 2 of the most abundant species of lowland Hawaiian forests.
Evidence for multiple drivers of aerial insectivore declines in North America
Authors: Spiller Kimberly J , Dettmers Randy 
Published: July 2019

AbstractAerial insectivores (birds that forage on aerial insects) have experienced significant population declines in North America. Numerous hypotheses have been proposed for these declines, but current evidence suggests multiple factors could be operating in combination during their annual migratory cycles between breeding and nonbreeding areas. Potential drivers include decreased prey abundance, direct or indirect impacts of environmental contaminants, habitat loss, phenological changes due to warming climate, and conditions on migratory stopover or wintering grounds. While no single threat appears to be the cause of aerial insectivore declines, existing evidence suggests that several of these factors could be contributing to the declines at different times in the annual lifecycle. Breeding productivity for most of these species does not appear to be limited by overall prey abundance, contaminants, or habitat loss, which suggests that similar issues on nonbreeding grounds or carryover effects could play important roles. However, a better understanding of the importance of prey quality throughout the lifecycle is critically needed. Based on current evidence, we propose that changes in availability of high-quality prey, with variability across breeding and nonbreeding grounds, reduce various combinations of fledging success, post-fledging survival, and nonbreeding season body condition of aerial insectivores, resulting in species and geographic differences in population trends. We encourage others to use this hypothesis as a starting point to test specific mechanisms by which availability of high-quality prey influences demographic parameters. We suggest that future research focus on defining prey quality, monitoring insect abundance in conjunction with birds, comparing demographic models across local populations experiencing different population growth rates, and using tracking technology to document important migratory and nonbreeding areas. Considerable research progress already has been made, but additional research is needed to better understand the complex web of potential causes driving aerial insectivore declines.
Cumulative impacts of roads and energy infrastructure on grassland songbirds
Authors: Daniel Jody , Koper Nicola 
Published: July 2019

Abstract
Comparing impacts of co-occurring anthropogenic features is necessary for regional planning and can help identify mechanisms of negative impacts of development on wildlife. Because of the vast abundance of anthropogenic features in the Northern Great Plains, their combined negative impacts on songbird habitat use (e.g., abundance) and productivity (e.g., nesting success and clutch size) could exacerbate the decline of songbird populations. We compared the cumulative effects of energy-related infrastructure (oil wells, shallow gas wells, and roads) on habitat use and productivity of songbirds across a 120 × 180 km region in southern Alberta, Canada. We examined effects on Chestnut-collared Longspur (Calcarius ornatus) and Sprague’s Pipit (Anthus spragueii), both of which are listed as Threatened in Canada, and Savannah Sparrow (Passerculus sandwichensis), Vesper Sparrow (Pooecetes gramineus), and Western Meadowlark (Sturnella neglecta). Using piecewise regressions and generalized linear models, we estimated effects of distance from infrastructure and shallow gas well density on the habitat use and productivity of each species. We then used these analyses to quantify the availability of habitat suitable for settlement and breeding throughout our study region. Shallow gas wells, which are more abundant, affected a larger geographic area than oil wells, but oil wells were associated with the added impacts of roads. Our analyses suggest that impacts of wells on songbirds are not caused by industrial noise because individual shallow gas wells, which produce no mechanical noise, had similar impacts to noisy oil wells. Our results highlight the importance of regional plans that consider the impacts of multiple co-occurring anthropogenic features in working landscapes.
Delayed presentation of right ventricular lead perforation following defibrillator implantation: a case report
Authors: Ahlert Daniel , Mitchell Andrew R J 
Published: July 2019

Abstract

Background
Perforation of a device lead through the myocardium is a recognized complication of cardiac device implantation. The associated morbidity and mortality are significant, even though it is a relatively rare complication. Therefore, it is vital for acute clinicians to be aware of the diagnosis and subsequent management of myocardial perforation.

Case summary
We present the case of a 48-year-old woman who presented to the emergency department 1 month following implantable cardioverter-defibrillator implantation with chest and shoulder pain. Initial assessment revealed bilateral pleural effusions and anaemia. Computerized tomography of her chest and abdomen demonstrated a pericardial effusion, but it was transthoracic echocardiography that confirmed the diagnosis of right ventricular perforation. Urgent system revision was undertaken.

Discussion
This case highlights the importance of clinical suspicion and the use of diagnostic echocardiography as an important diagnostic tool in symptomatic patient’s post-cardiac device implantation.
A case report: use of cerebral oximetry in the early detection of cerebral hypoperfusion in a post-cardiac arrest patient during targeted temperature management
Authors: Ng Shonda , Chia Yew Woon 
Published: July 2019

Abstract

Background
We present a patient who received cerebral oximetry monitoring during targeted temperature management (TTM) post-cardiac arrest and discuss its potential in the early detection of cerebral hypoperfusion and implications on haemodynamics and ventilatory management.

Case summary
A 60-year-old Chinese male was admitted for acute pulmonary oedema with Type 2 respiratory failure. He failed an initial trial of non-invasive ventilation and was planned for intubation and mechanical ventilation. However, the patient suffered a pulseless electrical activity cardiac arrest peri-intubation. He was started on our institution’s protocolized post-cardiac arrest care bundle, which included cerebral regional oxygen saturation (rSO2) monitoring and TTM. Initial arterial blood gas (ABG) post-return of spontaneous circulation showed severe respiratory acidosis, and the patient was sedated, paralyzed, and ventilator settings optimized. Repeat ABG showed resolution of respiratory acidosis. However, a drop in rSO2 to 35% was subsequently noted. Ventilator settings were quickly adjusted, and dobutamine was started to improve global and cerebral perfusion. These measures improved cerebral rSO2 to more than 50%. Patient was cooled for 24 h and gradually rewarmed. He was later extubated with a cerebral performance category of 1 and is now on outpatient follow-up.

Discussion
During post-cardiac arrest care, there are many factors which can contribute to a decrease in cerebral blood flow. Therapeutic hypothermia and ventilation strategies, including the use of neuromuscular blocking agents, can both reduce pCO2 which is a major regulator of cerebrovascular tone. Accidental hypocapnia can lead to adverse cerebral vasoconstriction and hypoperfusion. Without cerebral oximetry, cerebral ischaemia may not be detected early and can potentially result in secondary brain injury.
Profiling off-label prescriptions in cancer treatment using social health networks
Authors: Nikfarjam Azadeh , Ransohoff Julia D , Callahan Alison , Polony Vladimir , Shah Nigam H 
Published: July 2019

AbstractObjectivesTo investigate using patient posts in social media as a resource to profile off-label prescriptions of cancer drugs.MethodsWe analyzed patient posts from the Inspire health forums (www.inspire.com) and extracted mentions of cancer drugs from the 14 most active cancer-type specific support groups. To quantify drug-disease associations, we calculated information component scores from the frequency of posts in each cancer-specific group with mentions of a given drug. We evaluated the results against three sources: manual review, Wolters-Kluwer Medi-span, and Truven MarketScan insurance claims.ResultsWe identified 279 frequently discussed and therefore highly associated drug-disease pairs from Inspire posts. Of these, 96 are FDA approved, 9 are known off-label uses, and 174 do not have records of known usage (potentially novel off-label uses). We achieved a mean average precision of 74.9% in identifying drug-disease pairs with a true indication association from patient posts and found consistent evidence in medical claims records. We achieved a recall of 69.2% in identifying known off-label drug uses (based on Wolters-Kluwer Medi-span) from patient posts.
Photoactive yellow protein and its chemical probes: an approach to protein labelling in living cells
Authors: Kumar Naresh , Hori Yuichiro , Kikuchi Kazuya 
Published: July 2019

Abstract
Labelling technologies developed over the past few years have changed the way of looking at biomolecules and have made a considerable contribution to our understanding of the functions and regulation of dynamic biological processes. One of the robust technologies employed to image proteins in a cellular environment is based on the use of chemical tags and their fluorescent probes, which provides flexibility in developing probes with a wide range of synthetic fluorophores. A variety of chemical tags, ranging from short amino acid sequences to small proteins, have been employed to generate protein-labelling systems. One such chemical tag is the photoactive yellow protein (PYP)-tag, which is a small bacterial protein, developed for the selective labelling and imaging of proteins. Herein, we briefly discuss the protein-labelling system developed based on PYP-tag technology, with a focus on the design strategy for PYP-tag labelling probes and their applications in protein imaging.
The Economics of Honey Bee (Hymenoptera: Apidae) Management and Overwintering Strategies for Colonies Used to Pollinate Almonds
Authors: Degrandi-Hoffman Gloria , Graham Henry , Ahumada Fabiana , Smart Matthew , Ziolkowski Nick 
Published: July 2019

Abstract
Commercial honey bee (Apis mellifera L.) colonies significantly contribute to agricultural productivity through crop pollination. Almond production requires the most colonies because there are more than a million acres of orchards that require cross-pollination for nut set. With the rising costs of managing and transporting colonies to almond orchards combined with the high colony losses beekeepers routinely experience, we asked if renting colonies for almond pollination was profitable. We conducted a longitudinal study on 190 colonies from their establishment in April until they were placed in almond orchards 10 mo later. In the fall, equal numbers of colonies were placed either in cold storage (CS) facilities or in outdoor apiaries for the winter. We found that the cost of overwintering colonies in CS was lower than in apiaries, but CS did not reduce overwintering losses. A key finding from our study is that there is little or no profit in renting colonies for almond pollination once summer management and overwintering costs are considered. Our only profitable venture was honey production in the summer. We propose alternative management strategies to lower costs and make almond pollination profitable. We also developed a decision tool for selecting colonies to overwinter in CS and reduce expenditures on those that will not reach sufficient size for almond pollination. Our study exposes the unsustainable financial burden experienced by migratory beekeepers that is not included in estimates of yearly colony losses, and underscores the urgent need for forage plantings to generate revenue from honey and improve overwinter survival.
Postharvest Population Reservoirs of Coffee Berry Borer (Coleoptera: Curculionidae) on Hawai’i Island
Authors: Johnson Melissa A , Fortna Samuel , Hollingsworth Robert G , Manoukis Nicholas C 
Published: July 2019

AbstractCoffee berry borer, Hypothenemus hampei Ferrari (Coleoptera: Curculionidae: Scolytinae), is the most damaging insect pest of coffee worldwide. Old coffee berries (raisins) are widely acknowledged as coffee berry borer reservoirs, yet few studies have attempted to quantify coffee berry borer populations in raisins remaining on farms postharvest. We collected ground and tree raisins at six coffee farms on Hawai’i Island to assess raisin density, infestation, coffee berry borer abundance, and adult mortality in three areas of each farm: trees, driplines (ground below the tree foliage), and center aisles (ground between tree rows). We also assessed infestation of the new season’s crop by conducting whole-tree counts of infested green berries. Mean raisin density was significantly higher in the dripline compared to the center aisle and trees (131 vs 17 raisins per m2 and 12 raisins per tree, respectively). Raisin infestation was significantly higher in samples from trees (70%) relative to those from the dripline (22%) and center aisle (18%). Tree raisins had significantly higher coffee berry borer abundance compared to both areas of the ground (20 vs 3–5 coffee berry borer per raisin). Adult mortality was significantly higher on the ground (63–71%) compared to the trees (12%). We also observed a significant positive correlation between ground raisin density and infestation of the new season’s crop. Across all farms, we estimated that 49.5% of the total coffee berry borer load was present in dripline raisins, 47.3% in tree raisins, and 3.2% in center aisle raisins. Our findings confirm the importance of whole-farm sanitation in coffee berry borer management by demonstrating the negative impact that poor postharvest control can have on the following season’s crop.
Primary labral reconstruction in patients with femoroacetabular impingement, irreparable labral tears and severe acetabular chondral defects decreases the risk of conversion to total hip arthroplasty: a pair-matched study
Authors: Maldonado David R , Go Cammille C , Laseter Joseph R , Lall Ajay C , Kopscik Michael R , Domb Benjamin G 
Published: July 2019

AbstractIn the presence of severe acetabular cartilage defects, the benefits of labral reconstruction (RECON) versus labral resection (RESEC) have not been determined. Prospectively collected data between October 2008 and December 2016 were retrospectively reviewed. Inclusion criteria were hip arthroscopy, acetabular Outerbridge grade III/IV, irreparable labral tears that underwent RECON or RESEC, and minimum 2-year postoperative measures for the modified Harris Hip Score, Non-Arthritic Hip Score, Hip Outcome Score–Sports Specific Subscale, International Hip Outcome Tool, Patient Satisfaction and Visual Analogue Scale for pain. Exclusion criteria included Tönnis grade &gt;1, previous hip conditions or previous ipsilateral hip surgeries. A 1:1 matched-pair analysis was performed based on age ±5 years, sex, body mass index ±5 kg/m2, Tönnis grade, acetabular microfracture, femoral Outerbridge grade (0 or I compared with II, III or IV). Relative risk (RR) and conversion rate to total hip arthroplasty (THA) were calculated. A total of 38 RECON hips were successfully matched. Both groups demonstrated significant improvements in patient-reported outcomes (PROs). THA conversion was 5.3% and 21.1% for the RECON and RESEC groups, respectively (P = 0.04). RECON was four times less likely to require THA conversion than the RESEC group (RR=4.0; 95% CI 0.91–17.63). In the setting of primary arthroscopic management of femoroacetabular impingement, irreparable labral tears and acetabular chondral lesions of Outerbridge III/IV, patients that underwent RECON and RESEC experienced significant improvement in PROs at minimum 2-year follow-up, and these functional scores were comparable when groups were matched. However, RR and rate to THA conversion were significantly higher in the RESEC group.
Marking RNA: m6A writers, readers, and functions in Arabidopsis
Authors: Reichel Marlene , Köster Tino , Staiger Dorothee 
Published: July 2019

AbstractN6-methyladenosine (m6A) emerges as an important modification in eukaryotic mRNAs. m6A has first been reported in 1974, and its functional significance in mammalian gene regulation and importance for proper development have been well established. An arsenal of writer, eraser, and reader proteins accomplish deposition, removal, and interpretation of the m6A mark, resulting in dynamic function. This led to the concept of an epitranscriptome, the compendium of RNA species with chemical modification of the nucleobases in the cell, in analogy to the epigenome. While m6A has long been known to also exist in plant mRNAs, proteins involved in m6A metabolism have only recently been detected by mutant analysis, homology search, and mRNA interactome capture in the reference plant Arabidopsis thaliana. Dysregulation of the m6A modification causes severe developmental abnormalities of leaves and roots and altered timing of reproductive development. Furthermore, m6A modification affects viral infection. Here, we discuss recent progress in identifying m6A sites transcriptome-wide, in identifying the molecular players involved in writing, removing, and reading the mark, and in assigning functions to this RNA modification in A. thaliana. We highlight similarities and differences to m6A modification in mammals and provide an outlook on important questions that remain to be addressed.
Preliminary Evidence for a Hormetic Effect on DNA Nucleotide Excision Repair in Veterans with Gulf War Illness
Authors: Latimer Jean J , Alhamed Abdullah , Sveiven Stefanie , Almutairy Ali , Klimas Nancy G , Abreu Maria , Sullivan Kimberly , Grant Stephen G 
Published: July 2019

AbstractIntroductionVeterans of the 1991 Gulf War were potentially exposed to a mixture of stress, chemicals and radiation that may have contributed to the persistent symptoms of Gulf War Illness (GWI). The genotoxic effects of some of these exposures are mediated by the DNA nucleotide excision repair (NER) pathway. We hypothesized that individuals with relatively low DNA repair capacity would suffer greater damage from cumulative genotoxic exposures, some of which would persist, causing ongoing problems.Materials and MethodsBlood samples were obtained from symptomatic Gulf War veterans and age-matched controls. The unscheduled DNA synthesis assay, a functional measurement of NER capacity, was performed on cultured lymphocytes, and lymphocyte mRNA was extracted and analyzed by sequencing.ResultsDespite our hypothesis that GWI would be associated with DNA repair deficiency, NER capacity in lymphocytes from affected GWI veterans actually exhibited a significantly elevated level of DNA repair (p = 0.016). Both total gene expression and NER gene expression successfully differentiated individuals with GWI from unaffected controls. The observed functional increase in DNA repair capacity was accompanied by an overexpression of genes in the NER pathway, as determined by RNA sequencing analysis.ConclusionWe suggest that the observed elevations in DNA repair capacity and NER gene expression are indicative of a “hormetic,” i.e., induced or adaptive protective response to battlefield exposures. Normally such effects are short-term, but in these individuals this response has resulted in a long-term metabolic shift that may also be responsible for the persistent symptoms of GWI.