bluuebunny/crossref_metadata_2025_split huggingface dataset:
Differential Signaling Mediated by ApoE2, ApoE3, and ApoE4 in Human Neurons Parallels Alzheimer’s Disease Risk
Authors: Huang Yu-Wen Alvin , Zhou Bo , Nabet Amber M. , Wernig Marius , Südhof Thomas C. 
Published: November 2018

AbstractApolipoprotein E (ApoE) mediates clearance of circulating lipoproteins from blood by binding to ApoE receptors. Humans express three genetic variants, ApoE2, ApoE3, and ApoE4, that exhibit distinct ApoE receptor binding properties. In brain, ApoE is abundantly produced by activated astrocytes and microglia, and three variants differentially affect Alzheimer’s disease (AD), such that ApoE2 protects against, and ApoE4 predisposes to the disease. A role for ApoE4 in driving microglial dysregulation and impeding Aβ clearance in AD is well documented, but the direct effects of three variants on neurons are poorly understood. Extending previous studies, we here demonstrate that ApoE variants differentially activate multiple neuronal signaling pathways and regulate synaptogenesis. Specifically, using human neurons cultured in the absence of glia to exclude indirect glial mechanisms, we show that ApoE broadly stimulates signal transduction cascades which among others enhance synapse formation with an ApoE4>ApoE3>ApoE2 potency rank order, paralleling the relative risk for AD conferred by these variants. Unlike the previously described induction ofAPPtranscription, however, ApoE-induced synaptogenesis involves CREB rather than cFos activation. We thus propose that in brain, ApoE acts as a glia-secreted paracrine signal and activates neuronal signaling pathways in what may represent a protective response, with the differential potency of ApoE variants causing distinct levels of chronic signaling that may contribute to AD pathogenesis.
A new energy-based model to predict spray droplet diameter in comparison with momentum-based models
Authors: Karimaei Hadiseh , Hosseinalipour Seyed Mostafa , Ghorbani Ramin 
Published: October 2018

Purpose
To estimate mean droplet diameter (MDD) of a spray, three different numerical models were used in this paper. One of them is investigation of the surface instability of the liquid sheet producing from an injector.

Design/methodology/approach
First, the linear instability (LI) analysis introduced by Ibrahim (2006) is implemented. Second, the improved (ILI) analysis already introduced by the present authors is used. ILI analysis is different from the prior analysis, so that the instability of hollow-cone liquid sheet with different cone angles is investigated rather than a cylindrical liquid sheet. It means that besides the tangential and axial movements, radial movements of the liquid sheet and gas streams have been considered in the governing equations. Beside LI theory as a momentum-based approach, a new model as a theoretical energy-based (TEB) model based on the energy conservation law is proposed in this paper.

Findings
Based on the energy-based approach, atomization occurs because of kinetic energy loss. The resulting formulation reveals that the MDD is inversely proportional to the atomization efficiency and liquid Weber number.

Research limitations/implications
The results of these three models are compared with the available experimental data. Prediction obtained by the proposed TEB model is in reasonable agreement with the result of experiment.

Practical implications
The results of these three models are compared with the available experimental data. Prediction of the proposed energy-based theoretical model is in very good agreement with experimental data.

Originality/value
Comparison between the results of new model, experimental data, other previous methods show that it can be used as a new simple and fast model to achieve good estimation of spray MDD.
Nationalism, part of the identity of East Timor
Authors: Berlie Jean A. 
Published: October 2018

Purpose
The purpose of this paper is to study the just and highly praised Timorese nationalism leading to independence, deal, in particular, with the attitude of the East Timorese and raise questions about their national identity.

Design/methodology/approach
This paper is largely based on an anthropological and political science research with interviews.

Findings
East Timor’s nationalism is unique and formerly linked to Liurai chiefs. Political nationalism is discussed in the third part of the paper.

Originality/value
This research is the first of its kind. East Timor research is mainly centered in the period 1975–1999 of Indonesian occupation. The concepts nationalism, identity and politics are under-researched concepts in East Timor. There the political system is unique.
The insoluble problems of books: what does Altmetric.com have to offer?
Authors: Torres-Salinas Daniel , Gorraiz Juan , Robinson-Garcia Nicolas 
Published: October 2018

Purpose
The purpose of this paper is to analyze the capabilities, functionalities and appropriateness of Altmetric.com as a data source for the bibliometric analysis of books in comparison to PlumX.

Design/methodology/approach
The authors perform an exploratory analysis on the metrics the Altmetric Explorer for Institutions, platform offers for books. The authors use two distinct data sets of books. On the one hand, the authors analyze the Book Collection included in Altmetric.com. On the other hand, the authors use Clarivate’s Master Book List, to analyze Altmetric.com’s capabilities to download and merge data with external databases. Finally, the authors compare the findings with those obtained in a previous study performed in PlumX.

Findings
Altmetric.com combines and orderly tracks a set of data sources combined by DOI identifiers to retrieve metadata from books, being Google Books its main provider. It also retrieves information from commercial publishers and from some Open Access initiatives, including those led by university libraries, such as Harvard Library. We find issues with linkages between records and mentions or ISBN discrepancies. Furthermore, the authors find that automatic bots affect greatly Wikipedia mentions to books. The comparison with PlumX suggests that none of these tools provide a complete picture of the social attention generated by books and are rather complementary than comparable tools.

Practical implications
This study targets different audience which can benefit from the findings. First, bibliometricians and researchers who seek for alternative sources to develop bibliometric analyses of books, with a special focus on the Social Sciences and Humanities fields. Second, librarians and research managers who are the main clients to which these tools are directed. Third, Altmetric.com itself as well as other altmetric providers who might get a better understanding of the limitations users encounter and improve this promising tool.

Originality/value
This is the first study to analyze Altmetric.com’s functionalities and capabilities for providing metric data for books and to compare results from this platform, with those obtained via PlumX.
Price and distribution range of logistics service providers considering market competition
Authors: Du Fei , Ang Sheng , Yang Feng , Yang Chenchen 
Published: October 2018

Purpose
The purpose of this paper is to analyze the relationship between market competition and distribution strategy for logistics service providers (LSPs), including freight price, service level (delivery speed), and service coverage.

Design/methodology/approach
The authors consider two risk-neutral LSPs in which one is an existing company and the other is a new entrant. The existing LSP has a sound distribution network and provides service in both local and remote areas. The new entrant LSP should determine the freight price and service coverage to compete for business. The authors use a Stackelberg game to model the competition between two LSPs with assumptions of consumers’ utility and demand distribution. Numerical examples are used to validate the findings.

Findings
The findings show that the distribution strategy for LSPs depends on the ratio of the cost difference and shipping speed difference and demand structure. The LSP with higher shipping speeds only need to meet demands in local areas and may stay out of the market in some cases. To compete for business in the whole areas is more profitable for the LSP with lower shipping speeds when either unit service cost or the potential demand in remote areas is low enough. Otherwise, the LSP with lower speeds should stay out the market of remote areas.

Originality/value
This study is a preliminary research on the relationship between market competition and distribution strategy for LSPs and contributes to service operations management literature and strategic management for LSPs.
The roles of message appeals and orientation on social media brand communication effectiveness
Authors: Kusumasondjaja Sony 
Published: October 2018

PurposeThe purpose of this paper is to explore the effectiveness of brand communication activities on Facebook, Twitter, and Instagram among major Indonesian brands by assessing the message appeals, orientation, and consumer responses.Design/methodology/approachA content analysis of 10,752 social media posts was conducted from the official Facebook, Twitter, and Instagram accounts of 43 leading brands in Indonesia during a six-month period between July and December 2016. The data collected from each individual social media post generated by those brands were coded and analysed in terms of their message appeal, orientation, and responses.FindingsInteractive brand posts were responded more frequently than informative message content. Twitter was more effective for informative appeal, Facebook worked better for interactive entertainment posts, and Instagram was more suitable for interactive content combining informative–entertainment appeals. Interactive brand post with mixed appeals received the most responses in Facebook and Instagram, while self-oriented message with informative appeal obtained the least.Research limitations/implicationsThe findings expand the marketing literature about new media for marketing communication and suggest marketing practitioners the importance of different creative brand communication strategies to enhance social media marketing effectiveness when using multiple platforms.Originality/valueThis is among the first studies to compare the effectiveness of creative message strategy on multiple social media platforms as well as to present insightful findings on social media marketing practices in Indonesia.
Does lifting the objective-price constraint in revenue recognition increase the value relevance of earnings and revenue?
Authors: Lu Hung-Yuan , Wang Sophia 
Published: October 2018

Purpose
This paper examines how managerial discretion and judgment in revenue recognition affect earnings and revenue value relevance. Specifically, the purpose of this paper is to assess the impact of lifting the objective-price constraint in revenue recognition on the value relevance of earnings and revenue by examining firms’ contemporaneous returns-earnings/revenue relation before and after the implementation of Accounting Standards Update (ASU) 2009-13. In addition, this paper examines how the change in earnings value relevance is conditioned by agency costs, corporate governance, information environment, and audit quality. This paper further examines whether earnings, revenue, and accruals quality change after the objective-price constraint is lifted.

Design/methodology/approach
This paper employs a difference-in-differences research design to examine whether earnings and revenue value relevance are enhanced or lowered more for a list of 107 US firms that applied selling price estimates in revenue recognition under ASU 2009-13 than for a list of 107 matched US firms that did not apply selling price estimates. Sub-sample analyses are employed to examine how agency costs, corporate governance, information environment, and audit quality condition the change in value relevance. Additional analyses examine the changes in earnings, revenue, and accruals quality using accruals, revenue accruals, discretionary revenue, absolute abnormal accruals, earnings/revenue predictability, and smoothness.

Findings
The empirical results suggest that lifting the objective-price constraint in revenue recognition improves earnings and revenue value relevance for positive earnings and that the effect of information usefulness dominates that of managerial opportunism. Change in the earnings value relevance is conditioned by the level of corporate governance, information environment, and audit quality. Evidence of no significant reduction in the earnings/revenue/accruals quality corroborates the main findings.

Research limitations/implications
The findings lend support to the new revenue standard (ASU 2014-09) that continues the use of the estimates of selling price in revenue recognition.

Originality/value
This study provides some of the first evidence that managerial judgment exercised in revenue recognition through the use of selling price estimates (i.e. lifting the objective-price constraint in revenue recognition) enhances earnings and revenue value relevance while such benefit does not come at a cost of reduced earnings/revenue/accruals quality.
Combining Marxism and China’s practices for the development of a socialist political economy with Chinese characteristics
Authors: Liu Wei 
Published: October 2018

Purpose
The socialist construction with Chinese characteristics must be based on history and reality. According to the requirements of liberation and development of productivity, efforts must be made to reform and improve the production relations, as well as continually consolidate the socialist system with Chinese characteristics. The purpose of this paper is to prove the necessity and superiority of a socialist system through China’s modernization achievements.

Design/methodology/approach
Marxist political economics is a critical legacy from classical economics. Its core question is also social production and distribution, which is epitomized in the labor theory of value and the theory of surplus value.

Findings
Regarding the significant principles that must be followed, these speeches summarized the logical system and prominent features of the socialist political system in the new normal from several significant and interrelated aspects such as basic methods, core propositions, main tasks and fundamental goals.

Originality/value
The socialist system with Chinese characteristics will gradually appear through further research and prove its superiority. How can a socialist system with Chinese characteristics innovate and develop? Does the system have a future? Is there any historical necessity for the socialist system to replace the capitalist system in human history? These are the questions that need urgent answers and in-depth exploration.
Executable platform for managing customizable metadata of educational resources
Authors: Abdyssalam Alhaag Amel , Savic Goran , Milosavljevic Gordana , Tima Segedinac Milan , Filipovic Milorad 
Published: October 2018

PurposeThe purpose of this research is to enable dynamic customization of metadata that describes educational resources in digital repositories.Design/methodology/approachUsers need to describe educational resources in digital repositories according to a user-specific metadata set. As users generally do not have the skills to customize the software application manually, this approach relies on the techniques of model-driven software engineering, which should allow customization of the software application programmatically with no need to develop or order a new software application. An experiment was conducted to evaluate the proposed solution.FindingsA software platform for managing educational resources described by dynamically extendable metadata is proposed. The platform enables the creation of data models that are programmatically transformed to a Web application for the management of educational resources. In this way, users can create their own models of metadata that are relevant in a particular domain.Research limitations/implicationsThe solution has been verified by users with technical knowledge. The appropriateness of the model should still be explored for domain experts with little technical knowledge who desire to define new metadata in their domain.Practical implicationsThe solution can be used for digital repositories that store diverse educational resources. Each resource could be described using metadata that relates to the domain the resource belongs to.Originality/valueDigital repositories standardly describe educational resources using some general metadata, which are more focused on the physical characteristics of resources rather than their semantics. The proposed solution introduces custom domain-specific semantics into the description of the resources, which improves their retrieval.
Who is quitting? An analysis of the dis-adoption of climate smart sorghum varieties in Tanzania
Authors: Simtowe Franklin , Mausch Kai 
Published: October 2018

Purpose
New agricultural technologies are continuously generated and promoted for adoption by farmers with the expectation that they bring about higher benefits than older technologies. Yet, depending on the perceived benefits, the user of the technology may choose to stop using it. This paper aims to analyze what drives farmers to dis-adopt climate smart sorghum varieties in Tanzania.

Design/methodology/approach
The study uses cross-sectional farm household level data collected in Tanzania from a sample of 767 households. The determinants of dis-adoption are explored using a bivariate probit with sample selection model.

Findings
The authors find that while farmers switch between different sorghum varieties, most farmers actually quit sorghum production. Older farmers and those facing biotic stresses such attacks by birds are more likely to dis-adopt sorghum.

Practical implications
These findings suggest that there is scope for improving and sustaining the adoption of sorghum varieties in Tanzania once extension services are strengthened. The findings also point to a well-founded theory on the role of markets in enhancing the overall sustainability of food systems.

Social implications
The study findings have broader implications for understanding the sustainability of improved technology adoption

Originality/value
Dis-adoption is also positively associated with the lack of access to markets underscoring the role of markets in enhancing the overall sustainability of technology adoption and food systems.
Priority practices for addressing non-economic loss and damages caused by cyclones in Bangladesh
Authors: Chiba Yohei , Prabhakar S.V.R.K. , Islam Md. Atikul , Akber Md. Ali 
Published: October 2018

Purpose
This paper aims to identify and prioritize key non-economic loss and damages (NELDs) caused by the 2009 Cyclone Aila in Khulna District of Bangladesh and to identify appropriate practices to address the NELDs.

Design/methodology/approach
The analytic hierarchy process was applied to prioritize key criteria, NELD indicators and practices that should be integrated into disaster risk reduction decisions at the local level.

Findings
The results showed the need for prioritizing NELDs at the local level, and especially for integrating into DRR policy and planning for addressing NELDs. The results indicated that the national disaster management plan could be enhanced to address issues related to inaccessible sanitation, waterborne diseases and mental disorders, and the school discontinuation.

Research limitations/implications
The results are specific to Bangladesh. Readers may find them applicable to other similar country situations.

Practical implications
The suggested risk reduction practices for addressing NELDs are effective for policymakers to prepare for the future extreme cyclone disasters.

Social implications
The study identifies “compliance with societal value” as an important criterion for decision-making in the affected communities. Societal value can be a basis to determine effective practices to address the NELDs.

Originality/value
To the best of the authors’ knowledge, the study is the first ever effort to identify and prioritize NELDs of cyclones in the coastal areas of Bangladesh and therefore might have a greater implication for DRR policy of Bangladesh.
Factors of business relationships change in agribusiness input distribution channel
Authors: Gazdecki Michal 
Published: October 2018

Purpose
The purpose of this paper is to identify factors of change in business relationships among companies operating in agribusiness input distribution channel.

Design/methodology/approach
This study, based on a qualitative approach applying network perspective, is focused on agri-markets for plant protection products. Primary data were collected via individual in-depth interviews with among managers of trade companies operating on agri-inputs products market.

Findings
Although relation between input producers and trade companies on agri-inputs market is affected by a large number of factors, representatives of trade companies seem to be focused on a limited number of them. In particular two factors need to be underlined as main ones: contract conditions and structural changes on the markets which manifest themselves mainly by consolidation of market entities. The function differentiation of the trade companies results not only in generated sales but also in a larger intensity of interactions with other market operators and in the necessity of creating new relationships. In the long term, it may generate the intensification of competitive structures that occur at the same level in a distribution channel.

Research limitations/implications
Generalization based on qualitative approach employed in this paper requires further testing and quantitative validation.

Originality/value
Even though agri-markets appear to be well-suited for studying network systems, such an approach has hardly ever been used. Interactions between different kinds of entities on agri-markets are incredibly strong and complex. The paper contributes to the two fields. First, it provides results related to the business relationship dynamics, especially factors that trigger relation change. Second, paper contributes to the agribusiness markets theory, especially from the structural point of view.
When can B2B firms improve product innovation capability (PIC) through customer participation (CP)? The moderating role of inter-organizational relationships?
Authors: Zhang Jing , Zhu Miao 
Published: November 2018

Purpose
When can B2B firms improve product innovation capability (PIC) through customer participation (CP)? The purpose of this paper is to shed light on this interesting question by providing a framework to interpret how interorganizational relationships (IORs), including customer relationship commitments, firm’s relational capability and bilateral dependence structure moderate the relationship between CP and PIC.

Design/methodology/approach
A questionnaire survey is conducted among 376 business to business (B2B) firms located in mainland China. Six hypotheses on how IORs moderate the CP–PIC relationship are examined using hierarchical regression analysis technique.

Findings
The empirical research reveals that CP positively impacts PIC of B2B firms, which will be strengthened when either customer affective commitment, supplier’s relational capability or total interdependence is high. In addition, the relationship between CP and PIC weakens as customer’s calculative commitment or interdependence asymmetry strengthens.

Originality/value
This study enriches customer participation literature by highlighting the PIC outcomes of CP and examining the complex and contingent roles of the buyer–supplier relationship in moderating CP’s impact upon PIC.