bluuebunny/crossref_metadata_2025_split huggingface dataset:
The spatiotemporal expression and mineralization regulation of p75 neurotrophin receptor in the early tooth development
Authors: Zhao Manzhu , Wen Xiujie , Li Gang , Ju Yingxin , Wang Yingying , Zhou Zhi , Song Jinlin 
Published: October 2018

AbstractObjectiveThe aim of this study was to investigate the spatiotemporal expression and potential role of p75NTR in tooth morphogenesis and tissue mineralization.Materials and methodsThe dynamic morphology of the four stages (from the beginning of E12.5 d, then E13.5 d and E15.5 d, to the end of E18.5 d) was observed, and the expressions of p75NTR and Runx2 were traced. The ectomesenchymal stem cells (EMSCs) were harvested in vitro, and the biological characteristics were observed. Moreover, the mineralization capability of EMSCs was evaluated. The relations between p75NTR and ALP, Col‐1 and Runx2 were investigated.ResultsThe morphologic results showed that the dental lamina appeared at E12.5 d, the bud stage at E13.5 d, the cap stage at E15.5 d and the bell stage at E18.5 d. p75NTR and Runx2 showed the similar expression pattern. EMSCs from the four stages showed no significant difference in proliferation. But the positive rate of p75NTR in the E12.5 d cells was significantly lower than that in the other three stages (P < 0.05). Moreover, the higher positive rate of p75NTR the cells were, the stronger mineralization capability they showed. p75NTR was well positively correlated with the mineralization‐related markers ALP, Col‐1 and Runx2, which increased gradually with the mature of dental germs.Conclusionp75NTR might play an important role in the regulation of tooth morphogenesis, especially dental hard tissue formation.
Long‐term skill improvement among general dental practitioners after a short training programme in diagnosing calcified carotid artery atheromas on panoramic radiographs
Authors: Gustafsson Nils , Ahlqvist Jan , Levring Jäghagen Eva 
Published: October 2018

AbstractPurposeTo study general dental practitioners (GDPs) ability to detect calcified carotid artery atheromas (CCAAs) in panoramic radiographs (PRs) and if their diagnostic accuracy in long term is improved after a short training programme.MethodsFourteen GDPs had their diagnostic accuracy regarding CCAA in PR assessed at baseline, 2 weeks and 1 year after training. Comparison was made with a reference standard based on consensus results from two experienced oral and maxillofacial radiologists. At each session, 100 radiographs were assessed individually by the GDPs. After the baseline assessment, the GDPs participated in a 2‐hour training programme comprising a lecture and diagnostic training by calibration. The GDPs results before and after training were compared, as well as between follow‐up sessions.ResultsA significant improvement in diagnostic accuracy was observed with increased sensitivity (from 41.8% to 55.7%, P = 0.02) without a significant decrease in specificity (from 87.2% to 86.7%, P = 0.87). The Kappa values also increased (from 0.66 to 0.71, P = 0.04). At 1‐year follow‐up, the improvement compared to baseline remained significant. There were no significant changes between the 2‐week and 1‐year follow‐up assessment.ConclusionA short training programme can significantly and sustainable improve GDPs diagnostic accuracy regarding CCAA.
Signed distance‐based ORESTE for multicriteria group decision‐making with multigranular unbalanced hesitant fuzzy linguistic information
Authors: Tian Zhang‐peng , Nie Ru‐xin , Wang Jian‐qiang , Zhang Hong‐yu 
Published: October 2018

AbstractThe objective of this study is to develop an integrated approach for solving multicriteria group decision‐making problems with multigranular unbalanced hesitant fuzzy linguistic term sets (HFLTSs). Firstly, a signed distance‐based transformation function is proposed to unify multigranular unbalanced hesitant fuzzy linguistic (HFL) assessments. Secondly, a mathematical programming model based on the maximum consensus is constructed to allocate decision‐makers (DMs)' weights objectively. Thirdly, a new signed distance‐based preference score function is defined to aggregate HFL assessments and determine the weak ranking of alternatives, and a novel preference, indifference, and incomparability test framework is constructed to identify the subtle relations among alternatives. On these bases, a signed distance‐based ORESTE (Organísation, rangement et Synthèse de données relarionnelles, in French) method, in which knowledge regarding criterion values and weights are expressed as multigranular unbalanced HFLTSs, is developed to obtain the ranking of alternatives. Finally, an illustrative example, followed by sensitivity and comparative analyses, is presented to verify the feasibility and effectiveness of the proposed approach.
Self‐medication Hypothesis and Family Socialization Theory: Examining Independent and Common Mechanisms Responsible for Binge Drinking
Authors: Soloski Kristy L. 
Published: October 2018

For many, binge drinking behaviors start early and become a persistent pattern of use throughout the lifespan. In an effort to strengthen understanding of etiology, this study considered the mechanisms from the self‐medication hypothesis and family socialization theory. The goal was to identify whether emotional distress is a potential shared mechanism that accounts for the development of binge drinking in different developmental periods. This study used the National Longitudinal Study of Adolescent to Adult Health (Add Health) dataset to examine binge drinking across time for n = 9,421 participants ranging in age from 11 to 18 (M = 15.39, SD = 1.62) at Wave I and ranging from 24 to 32 (M = 28.09, SD = 1.61) at Wave IV of the study. Using an autoregressive cross‐lagged model, I examined how parent‐child closeness, depressive symptoms, and binge drinking were related over three developmental periods. In examining cross‐sectional and longitudinal relations, depressive symptoms were significantly related to binge drinking more often than parent‐child closeness; however, results indicated the self‐medication model may primarily account for concurrent drinking behaviors rather than long‐term. The family socialization theory was indicated to account for some variability above and beyond the self‐medication hypothesis. No indirect association between binge drinking and the parent‐child relationship was detected through depressive symptoms, failing to support a shared mechanism between the two theories. The results provide support for a multifaceted assessment process for substance using clients, and support the use of Multisystemic Family Therapy, Multidimensional Family Therapy, and perhaps Attachment‐Based Family Therapy.
New insights into adaptation and population structure of cork oak using genotyping by sequencing
Authors: Pina‐Martins Francisco , Baptista João , Pappas Georgios , Paulo Octávio S. 
Published: October 2018

AbstractSpecies respond to global climatic changes in a local context. Understanding this process, including its speed and intensity, is paramount due to the pace at which such changes are currently occurring. Tree species are particularly interesting to study in this regard due to their long generation times, sedentarism, and ecological and economic importance. Quercus suber L. is an evergreen forest tree species of the Fagaceae family with an essentially Western Mediterranean distribution. Despite frequent assessments of the species’ evolutionary history, large‐scale genetic studies have mostly relied on plastidial markers, whereas nuclear markers have been used on studies with locally focused sampling strategies. In this work, “Genotyping by sequencing” is used to derive 1,996 single nucleotide polymorphism markers to assess the species’ evolutionary history from a nuclear DNA perspective, gain insights into how local adaptation is shaping the species’ genetic background, and to forecast how Q. suber may respond to global climatic changes from a genetic perspective. Results reveal (a) an essentially unstructured species, where (b) a balance between gene flow and local adaptation keeps the species’ gene pool somewhat homogeneous across its distribution, but still allowing (c) variation clines for the individuals to cope with local conditions. “Risk of Non‐Adaptedness” (RONA) analyses suggest that for the considered variables and most sampled locations, (d) the cork oak should not require large shifts in allele frequencies to survive the predicted climatic changes. Future directions include integrating these results with ecological niche modeling perspectives, improving the RONA methodology, and expanding its use to other species. With the implementation presented in this work, the RONA can now also be easily assessed for other organisms.
Evolution of the Taebaeksan Basin, Korea: I, early Paleozoic sedimentation in an epeiric sea and break‐up of the Sino‐Korean Craton from Gondwana
Authors: Choi Duck K. 
Published: October 2018

AbstractThe Taebaeksan Basin is located in the mid‐eastern part of the southern Korean Peninsula and tectonically belonged to the Sino‐Korean Craton (SKC). It comprises largely the lower Paleozoic Joseon Supergroup and the upper Paleozoic Pyeongan Supergroup which are separated by a disconformity representing a 140 myr−long hiatus. This paper explores the early Paleozoic paleogeographical and tectonic evolution of the Taebaeksan Basin on the basis of updated stratigraphy, trilobite faunal assemblages, and detrital zircon U–Pb ages of the Joseon Supergroup. The Joseon Supergroup is a shallow marine siliciclastic‐carbonate succession ranging in age from the Cambrian Series 2 to Middle Ordovician. The Ongnyeobong Formation is the sole Upper Ordovician volcanic succession documented in the Taebaeksan Basin. It is suggested that in the early Paleozoic the Taebaeksan Basin was a part of an epeiric sea, the Joseon Sea, in east Gondwana. The Joseon Sea was the depositional site for lower Paleozoic successions of the SKC. Early Paleozoic sedimentation in the Joseon Sea commenced during the Cambrian Stage 3 (∼ 520 Ma) and ceased by the end of the Darriwilian (∼ 460 Ma). In the early Paleozoic, the SKC was located at the margin of east Gondwana and was separated from the South China Craton by an oceanic basin with incipient oceanic ridges, the Helan Trough. The spreading oceanic ridges and associated transform faults possibly promoted the uplift of the Joseon Sea, which resulted in cessation of sedimentation and break‐up of the SKC from core Gondwana by the end of the Ordovician.
Metabolic fingerprinting of water‐stressed soybean cultivars by gas chromatography, near‐infrared and UV‐visible spectroscopy combined with chemometrics
Authors: Uarrota Virgílio G. , Segatto Cristiane , Voytena Ana Paula L. , Maraschin Marcelo , Avila Linda Vásquez , Kazama Daniele C. S. , Coelho Cileide M. M. , Souza Clovis Arruda 
Published: October 2018

AbstractAiming to assess the impact of water deficit on agronomic, photosynthetic and biochemical parameters of two soybean cultivars during reproductive stage, soybean plants were subjected to three gravimetric humidity levels. Water deficit decreased the leaf relative water content, leaf dry matter content, dried pod weight, grain weight, chlorophyll activity, linolenic acid, pentadecanoid and palmitoleic acid, and increased stearic, lauric, linoleic, myristic, oleic, palmitic and tricosanoic acids. Reactive oxygen species production and lipid peroxidation were accompanied by the activation of antioxidant defence system. Changes in aliphatic hydrocarbons, aromatic hydrocarbons, methyl, methylene, aromatic amine, polysaccharides, phenolics, carotenoids, proteins, C‐H aryl group, alkyl alcohols, polyamide, amide, ethers and esters, primary amide, N‐H secondary amine were observed. Principal component analysis and network correlations revealed dried shoot weight, malondihaldeyde, phenolics, proline, guaiacol peroxidase, stearic, tricosanoic, linoleic, oleic, palmitic, myristic and lauric acids as the most important variables related to water deficit. Cultivar CV5959 was most tolerant than CV 5909. Despite the important variables found in this study, further research in data integration is needed for better understanding of the potential bio‐markers of water deficit and future development of its signalling pathways.
Reverse Ekphrasis: Teaching Poetry‐inspired Chinese Brush Painting Workshops – in English
Authors: Sui Gang 
Published: October 2018

AbstractThe artistic practices of ekphrasis and reverse ekphrasis – integrating poetry and painting in their unique forms – have been long‐standing conventions both in the East and in the West. This article attempts to rationalise the new functions of the age‐old concept of reverse ekphrasis (i.e. graphic representation of verbal representation) as reactivated for the purposes of today's university‐level art education, and as exemplified by the international workshops of poetry‐inspired Chinese brush painting that I taught at The University of Central Lancashire (UCLan), UK, from 2012 to 2016, using English not only as a convenient contact language for art education, but also as a powerful vehicle for poetic self‐reflection, intertextual adaptation and intermedial transformation. To be more concise, my teaching approaches featured CREATE – Contact (C), Reverse Ekphrasis (R, E), Adaptation (A), Transformation (T) and Enrichment (E). The international workshop participants’ creative painting outcomes proved that, as brush painters, they could draw inspiration effectively from poetry written in English and/or poetry translated into English, so as to increase their personal capacity for artistic self‐expression and intercultural communication through Chinese‐style brush painting.
“Living the life I want”: A framework for planning engagement with people with intellectual disability and complex support needs
Authors: Dew Angela , Collings Susan , Dillon Savage Isabella , Gentle Emma , Dowse Leanne 
Published: October 2018

AbstractBackgroundSelf‐determination involves autonomy, agency, choice and control. This study investigated how these aspects of self‐determination relate to engaging people with intellectual disability and complex support needs in setting goals and making plans.MethodBody mapping was used to understand the planning experiences of 30 adults with intellectual disability and complex support needs. Each participant created two body maps using a guided group‐based process. Visual and text data were thematically analysed and a framework for planning engagement developed.ResultsThe framework identifies the centrality of having a well‐developed sense of self which includes insight, motivation and agency, and which is shaped by contextual barriers and facilitators and influenced by helpful and unhelpful support.ConclusionsA well‐developed sense of self and ability to harness resources and people is fundamental to the ability of individuals with intellectual disability and complex support needs articulating goals, identifying aspirations, and attaining valued outcomes.
5,2′‐dibromo‐2,4′,5′‐trihydroxydiphenylmethanone attenuates LPS‐induced inflammation and ROS production in EA.hy926 cells via HMBOX1 induction
Authors: Yuan Hong‐Xia , Feng Xiu‐E , Liu En‐Li , Ge Rui , Zhang Yuan‐Lin , Xiao Bao‐Guo , Li Qing‐Shan 
Published: October 2018

AbstractInflammation and reactive oxygen species (ROS) are important factors in the pathogenesis of atherosclerosis (AS). 5,2′‐dibromo‐2,4′,5′‐trihydroxydiphenylmethanone (TDD), possess anti‐atherogenic properties; however, its underlying mechanism of action remains unclear. Therefore, we sought to understand the therapeutic molecular mechanism of TDD in inflammatory response and oxidative stress in EA.hy926 cells. Microarray analysis revealed that the expression of homeobox containing 1 (HMBOX1) was dramatically upregulated in TDD‐treated EA.hy926 cells. According to the gene ontology (GO) analysis of microarray data, TDD significantly influenced the response to lipopolysaccharide (LPS); it suppressed the LPS‐induced adhesion of monocytes to EA.hy926 cells. Simultaneously, TDD dose‐dependently inhibited the production or expression of IL‐6, IL‐1β, MCP‐1, TNF‐α, VCAM‐1, ICAM‐1 and E‐selectin as well as ROS in LPS‐stimulated EA.hy926 cells. HMBOX1 knockdown using RNA interference attenuated the anti‐inflammatory and anti‐oxidative effects of TDD. Furthermore, TDD inhibited LPS‐induced NF‐κB and MAPK activation in EA.hy926 cells, but this effect was abolished by HMBOX1 knockdown. Overall, these results demonstrate that TDD activates HMBOX1, which is an inducible protective mechanism that inhibits LPS‐induced inflammation and ROS production in EA.hy926 cells by the subsequent inhibition of redox‐sensitive NF‐κB and MAPK activation. Our study suggested that TDD may be a potential novel agent for treating endothelial cells dysfunction in AS.
Annual Research Review: Pediatric posttraumatic stress disorder from a neurodevelopmental network perspective
Authors: Weems Carl F. , Russell Justin D. , Neill Erin L. , McCurdy Bethany H. 
Published: October 2018

BackgroundExperiencing traumatic stress is common and may lead to posttraumatic stress disorder (PTSD) in a number of children and adolescents. Research using advanced imaging techniques is beginning to elucidate some of the neurobiological correlates of the traumatic stress response in youth.MethodsThis paper summarizes the emerging network perspective of PTSD symptoms and reviews brain imaging research emphasizing structural and functional connectivity studies that employ magnetic resonance imaging techniques in pediatric samples.ResultsDifferences in structural connections and distributed functional networks such as the salience, default mode, and central executive networks are associated with traumatic and severe early life stress. The role of development has been relatively underappreciated in extant studies though there is evidence that critical brain regions as well as the structural and functional networks implicated undergo significant change in childhood and these typical developmental differences may be affected by traumatic stress.ConclusionsFuture research will benefit from adopting a truly developmental approach that considers children's growth as a meaningful effect (rather than simply a covariate) interacting with traumatic stress to predict disruptions in the anatomical, functional, and connective aspects of brain systems thought to underlie the network of PTSD symptoms. Linking symptom networks with neurodevelopmental network models may be a promising avenue for future work.
JAK1/3 inhibition preserves epidermal morphology in full‐thickness 3D skin models of atopic dermatitis and psoriasis
Authors: Clarysse K. , Pfaff C.M. , Marquardt Y. , Huth L. , Kortekaas Krohn I. , Kluwig D. , Lüscher B. , Gutermuth J. , Baron J. 
Published: October 2018

AbstractBackgroundJanus kinase (JAK) inhibition may be a promising new treatment modality for inflammatory (skin) diseases. However, little is known about direct effects of kinase inhibitors on keratinocyte differentiation and function as well as skin barrier formation.ObjectiveOur aim was to address the direct impact of kinase inhibition of the JAK1/3 pathways by tofacitinib on keratinocyte immune function and barrier formation in atopic dermatitis (AD) and psoriasis.Methods3D skin equivalents of both diseases were developed and concurrently pretreated with tofacitinib. To induce AD, 3D skin equivalents were stimulated with recombinant human IL‐4 and IL‐13. Psoriasis‐like conditions were induced by incubation with IL‐17A, IL‐22 and tumour necrosis factor α (TNFα). The activation of signal transducer and activator of transcription (STAT)1, STAT3 and STAT6 was assessed by Western blot analysis. Microarray analysis and quantitative real‐time PCR were used for gene expression analysis.ResultsTofacitinib pretreatment preserved epidermal morphology and reduced STAT3 and STAT6 phosphorylation of AD‐like and STAT3 phosphorylation of psoriasis‐like culture conditions in 3D skin models compared to sham‐controls. Filaggrin expression was fully maintained in the AD‐like models, but only partially in psoriasis‐like conditions after pretreatment with tofacitinib. In addition, tofacitinib upregulated DSC1, FLG and KRT1. Using gene expression analysis, downregulation of POSTN and IL24 was observed in AD‐like conditions, whereas downregulation of IL20 and IL1B was observed in psoriasis‐like conditions.ConclusionJAK1/3 inhibition counteracted cytokine‐induced AD‐ and psoriasis‐like epidermal morphology and enhanced keratinocyte differentiation in 3D skin models. This effect was more pronounced in the AD‐like models compared to the psoriasis‐like 3D skin models.
Increased tumour cell PD‐L1 expression, macrophage and dendritic cell infiltration characterise the tumour microenvironment of ulcerated primary melanomas
Authors: Koelblinger P. , Emberger M. , Drach M. , Cheng P.F. , Lang R. , Levesque M.P. , Bauer J.W. , Dummer R. 
Published: October 2018

AbstractBackgroundPrimary melanoma ulceration is an unfavourable prognostic factor included in current staging systems. Yet, the immunological and molecular alterations responsible for this adverse outcome have not been fully elucidated.ObjectivesWe aimed to identify immunological differences between ulcerated and non‐ulcerated primary melanomas concerning both innate and adaptive immunity and to correlate these with clinical outcome.MethodsFormalin‐fixed paraffin‐embedded primary melanomas from 112 patients (pts) were analysed by immunohistochemistry. The expression of various markers identifying tumour‐infiltrating lymphocytes, macrophages and dendritic cells was evaluated semi‐quantitatively by three independent investigators. Tumour cell expression of programmed death‐ligand 1 (PD‐L1), transporter of antigen processing 1 and the MxA protein was also analysed.ResultsRecurrence occurred in 21/56 pts (37.5%) with ulcerated vs. 14/56 pts (25.0%) with non‐ulcerated tumours (P = 0.15). Tumour ulceration was associated with more frequent development of brain metastasis (17.6 vs. 3.6% of pts, P = 0.015). Immunohistochemistry showed an association of ulceration with the presence of intratumoural CD68+ macrophages (P = 0.028) as well as with increased numbers of intratumoural CD11c+ dendritic cells (P = 0.014) and CD163+ macrophages (P = 0.001). PD‐L1 positivity (expression in >1% of tumour cells) was more frequent in ulcerated than non‐ulcerated tumours [40 (72.7%) vs. 25 (44.6%), P = 0.003]. A positive correlation between intratumoural CD11c+ (Spearman's correlation coefficient ρ: 0.42) and CD163+ (ρ: 0.31) cell count and frequency of tumour cell PD‐L1 expression was detected.ConclusionsOur results confirm the adverse clinical outcome associated with primary melanoma ulceration, particularly concerning the risk of recurrence and subsequent development of brain metastases. The observed immunological differences suggest a conceivable role of increased intratumoural macrophage and dendritic cell counts associated with enhanced tumour cell PD‐L1 expression potentially contributing to the immunosuppressive, growth‐promoting microenvironment of ulcerated primary melanomas.