bluuebunny/crossref_metadata_2025_split huggingface dataset:
The emergence of Agile people management
Authors: Denning Stephen 
Published: July 2018

Purpose
As senior executives increasingly explore Agile management in their operations they are discovering that their practices in managing people also require transformation.

Design/methodology/approach
The article, with an attached case, explores how some leading companies are radically changing their HR practices to prioritize fostering talent that adds customer value and champion the work experience of their talent. The article explains why transformation will involve, not merely HR process improvements, but a fundamentally different kind of management. It offers a case to illustrate new approaches.

Findings
At a time when talent is in such high demand, you must allow—and even encourage—people to have their say if you hope to attract the very best in your field. So, the successful deployment of talent is now largely a matter of creating an environment where the interests, ambitions and innovations of people constantly shape the strategy and future of the company.

Practical implications
Instead of strategy gurus telling talent what to do, now talent needs to play a central role in strategy formulation. Imagine a company divided into some two hundred customer-facing units, each with its own pay scale and work methods, each so talent-driven that employees are given the right to fire their unit leader?

Originality/value
The shift from a strategy-led company to a talent-first company requires fundamental changes in the way CEOs understand the very concept of management—it’s the beginning of a new age.
Intranasal ovalbumin immunotherapy with mycobacterial adjuvant promotes regulatory T cell accumulation in lung tissues
Authors: Akkoç Tunç , Genç Deniz , Zibandeh Noushin , Akkoç Tolga 
Published: July 2018

ABSTRACTAllergen‐specific immunotherapy to induce T regulatory cells in the periphery has been used to treat allergic diseases. Mycobacteria can be used as an adjuvant for inducing T regulatory cells. However, it is unclear whether intranasal immunotherapy in combination with Mycobacteria adjuvant induces regulatory T cell differentiation and attenuates allergic responses in vivo. To investigate the role of intranasal ovalbumin (OVA) treatment alone and in combination with Mycobacteria vaccae, proportions of FoxP3+ regulatory T cells and anti‐inflammatory responses were evaluated in a murine model of asthma that was established in three groups of bicistronic Foxp3EGFP reporter BALB/c mice. Before establishment of the asthma model, two groups of mice received intranasal OVA immunotherapy and one also received simultaneous s.c. M. vaccae. Expression of CD4+CD25+Foxp3+EGFP+ T cells in the lung and spleen was analyzed by flow cytometry and the cytokine profiles of allergen‐stimulated lung and spleen lymphocytes assessed. The intranasal OVA immunotherapy group showed greater expression of CD4+CD25+Foxp3+EGFP+ T cells in the spleen whereas in the group that also received M. vaccae such greater expression was demonstrated in the lung. Additionally, the proportion of IL‐10 and IFN‐γ‐secreting splenocytes was greater in the intranasal OVA + M. vaccae group. CD25 neutralization decreased CD4+Foxp3+ cells more than other groups. In parallel with this finding, production of IL‐10 and IFN‐γ was down‐regulated. Mucosal administration of OVA antigen results in a greater proportion of CD4+Foxp3+ T cells in the spleen. IL‐10 and IFN‐γ induced by intranasal OVA immunotherapy and M. vaccae administration is down‐regulated after CD25 neutralization.
Asparaginase‐like protein 1 expression in curettage independently predicts lymph node metastasis in endometrial carcinoma: a multicentre study
Authors: Fonnes T , Trovik J , Edqvist P‐HD , Fasmer KE , Marcickiewicz J , Tingulstad S , Staff AC , Bjørge L , Amant F , Haldorsen IS , Werner HMJ , Akslen LA , Tangen IL , Krakstad C 
Published: July 2018

ObjectiveCorrect preoperative identification of high‐risk patients is important to optimise surgical treatment and improve survival. We wanted to explore if asparaginase‐like protein 1 (ASRGL1) expression in curettage could predict lymph node metastases and poor outcome, potentially improving preoperative risk stratification.DesignMulticentre study.SettingTen hospitals in Norway, Sweden and Belgium.PopulationWomen diagnosed with endometrial carcinoma.MethodsASRGL1 expression in curettage specimens from 1144 women was determined by immunohistochemistry.Main outcome measuresASRGL1 status related to disease‐specific survival, lymph node status, preoperative imaging parameters and clinicopathological data.ResultsASRGL1 expression had independent prognostic value in multivariate survival analyses, both in the whole patient population (hazard ratio (HR) 1.63, 95% CI 1.11–2.37, P = 0.012) and in the low‐risk curettage histology subgroup (HR 2.54, 95% CI 1.44–4.47, P = 0.001). Lymph node metastases were more frequent in women with low expression of ASRGL1 compared with women with high ASRGL1 levels (23% versus 10%, P < 0.001), and low ASRGL1 level was found to independently predict lymph node metastases (odds ratio 2.07, 95% CI 1.27–3.38, P = 0.003).ConclusionsLow expression of ASRGL1 in curettage independently predicts lymph node metastases and poor disease‐specific survival.Tweetable abstractLow ASRGL1 expression in curettage predicts lymph node metastasis and poor survival in endometrial carcinoma.
Detection of Tooth‐Colored Restorative Materials for Forensic Purposes Based on Their Optical Properties: An In Vitro Comparative Study
Authors: Kiran Ramya , Chapman James , Tennant Marc , Forrest Alexander , Walsh Laurence J. 
Published: July 2018

AbstractVictim identification using dental records involves antemortem and postmortem comparison of dental charts. Since dental restorations may be part of such records, identifying them accurately is critical. The objective of this study was to compare the diagnostic reliability and validity of two optical methods for identifying tooth‐colored restorations (digital imaging fiber optic transillumination (DiFOTI) using near infrared light, and fluorescence‐aided identification of restorations (FAIR)) with conventional diagnostic methods. Four examiners identified and charted tooth‐colored restorations in three sets of typodonts on the bench using conventional visual and tactile examination, DiFOTI (DIAGNOcam™) and FAIR. All examinations were repeated after 4 weeks. Both the sensitivity (95%) and specificity (97%) of the FAIR method were significantly higher than those for DiFOTI (82% and 82%) and for conventional inspection (71% and 82%). In conclusion, FAIR method performed better than conventional examination and DiFOTI, and was more reliable for identifying tooth‐colored restorations.
Cardiac Ventricular Laceration Due to Child Abuse: Abusive Ventricular Laceration
Authors: Yarid Nicole , Brown Emily C. , Boos Markus , Otjen Jeffrey , Metz James , Jenny Carole , Feldman Kenneth W. 
Published: July 2018

AbstractTraumatic cardiac ventricular ruptures in children are rare. Only a single case of left ventricular rupture due to child abuse has been reported. We report a child who sustained a fatal left ventricular apical rupture. It appeared to have resulted from hydrostatic forces resulting from abusive blunt thoracic injury. That he was being abused was previously missed when he was presented to the emergency department with facial pyoderma. It was not noted that he also had lip and oral mucosal injury, sites not affected by staph toxins. As a result, his underlying, abusive and secondarily infected, facial flow type scald burn was not appreciated. Within a week thereafter his fatal injury occurred, accompanied by extensive and obvious associated abusive injuries. Postmortem high‐detail whole body computed tomography scanning aided the autopsy. Although rare, ventricular rupture from abusive blunt thoracic injury can occur.
Simple Formula for Predicting Drug Removal Rates During Hemodialysis
Authors: Urata Motoki , Narita Yuki , Fukunaga Masaki , Kadowaki Daisuke , Hirata Sumio 
Published: July 2018

AbstractThe present study sought to derive a simple formula for predicting the drug removal rates during hemodialysis. We examined the relationship between drug removal rates during hemodialysis and the molecular weights or pharmacokinetic parameters of injectable drugs (N = 90) obtained from pharmaceutical interview forms in Japan. Stepwise multiple regression analysis with the removal rate by hemodialysis as the objective variable adjusted for molecular weight or pharmacokinetic parameters as explanatory variables, showed that the logarithm of molecular weight (B = −18.87), the protein binding rate (B = −0.40), and the fraction of the unchanged drug excreted into the urine/volume of distribution (B = 0.05) were significantly and independently associated with drug removal rate by hemodialysis (α = 90.78, adjusted R2 = 0.64, P = 2.2e−16). Our data demonstrated that molecular weight, protein binding rate, and volume of distribution were important factors affecting drug removal during hemodialysis, and that our simple regression equation could be used to predict the drug removal rate during hemodialysis.
Elevated Level of miR‐551b‐5p is Associated With Inflammation and Disease Progression in Patients With Severe Acute Pancreatitis
Authors: Zhang Yongpeng , Yan Liying , Han Wang 
Published: July 2018

ABSTRACTCirculating microRNAs have the potential to be noninvasive biomarkers for assessing disease progression. MicroRNA‐551b‐5p (miR‐551b‐5p) was previously reported to be differentially expressed in pancreatic patients. The serum miR‐551b‐5p level was measured in patients with mild acute pancreatitis (MAP), severe acute pancreatitis (SAP), and healthy controls using quantitative real‐time polymerase chain reaction (RT‐PCR) analysis to evaluate its impact on inflammatory response. Acute Physiology and Chronic Health Evaluation II (APACHE II), Multiple Organ Dysfunction Score (MODS), Sequential Organ Assessment Score (SOFA), and Ranson's scores were recorded. Inflammatory cytokines, IL‐6, IL‐17, IL‐1β, and Tumor Necrosis Factor‐α (TNF‐α), were detected in serum samples obtained from MAP and SAP patients on admission day 1, day 3, and day 5 using Enzyme Linked Immunosorbent Assay (ELISA). Inflammatory cytokines were analyzed in peripheral blood mononuclear cells (PBMCs), which were transfected with miR‐551b‐5p‐negative controls and inhibitors. The serum miR‐551b‐5p level was significantly higher in MAP and SAP patients compared to controls (P < 0.001). An elevated miR‐551b‐5p level is positively associated with APACHE II, MODS, SOFA, and Ranson's scores (P < 0.001). Serum cytokines levels were significantly elevated in MAP and SAP patients compared to controls (P < 0.05). In addition, the level of these inflammatory cytokines was increased in PBMCs of SAP patients in comparison with those of healthy controls (P < 0.05), and this rise was significantly reduced with the addition of an miR‐551b‐5p inhibitor. In conclusion, serum miR‐551b‐5p is elevated in patients with MAP and SAP and is involved in the regulation of inflammatory response. It may be a useful biomarker for assessing the severity of SAP.
Alcohol consumption, depressive symptoms, and the incidence of diabetes‐related complications
Authors: Elgendy Randa , Deschênes Sonya S. , Burns Rachel J. , Levy Melanie , Schmitz Norbert 
Published: July 2018

AbstractBackgroundHeavy alcohol consumption in individuals with type 2 diabetes mellitus (T2DM) is related to increased risks of diabetes‐related micro‐ and macrovascular complications. Depressive symptoms may be relevant to this relationship, because high depressive symptoms are associated with an increased risk of complications. This study investigated whether the interaction between depressive symptoms and alcohol frequency was positively related to the development of neuropathy, retinopathy, nephropathy, and coronary artery disease (CAD), such that those with high depressive symptoms and high alcohol frequency will be at increased risk of complications.MethodsData were from five waves of the Evaluation of Diabetes Treatment annual survey including 1413 adults with T2DM in Quebec. Data on alcohol frequency (number of drinking occasions), depressive symptoms, and complications were collected annually. The development of each complication was investigated using multiple logistic regression analysis with generalized estimating equations.ResultsAfter adjusting for sociodemographic, lifestyle, and diabetes‐related covariates, the interaction between alcohol frequency and depressive symptoms was positively related to the incidence of neuropathy and CAD, such that those with high depressive symptoms who drank the most frequently had the highest risk of neuropathy (odds ratio [OR] 1.02, 95% confidence interval [CI] 1.00–1.04; P = 0.04) and CAD (OR 1.02, 95% CI 1.00–1.04; P = 0.04). This interaction was not significantly related to retinopathy or nephropathy.ConclusionIndividuals with high depressive symptoms and high alcohol frequency may have a particularly high risk of neuropathy and CAD. Future prevention efforts should examine both alcohol frequency and depressive symptoms when evaluating the risk of complications.
Trends and characteristics of naloxone therapy reported to US poison centers
Authors: Rege Saumitra V. , Ngo Duc Anh , Ait‐Daoud Nassima , Sharma Sana , Verplancken Evan , Holstege Christopher P. 
Published: July 2018

AbstractBackground and aimsIn the United States, access to naloxone has been expanded as a measure to address growing opioid overdose mortality. The study aimed to describe the national trends in naloxone use as reported to the US poison centers (PCs).MethodsThe National Poison Data System (NPDS) was queried for cases reporting naloxone therapy from 1 January 2001 to 31 December 2016. Demographic and clinical characteristics were assessed descriptively. Trends in naloxone reports were evaluated by using generalized linear mixed models that were adjusted for age, gender and random effects of the geographical census region. Cumulative incidence rates (CIR) of naloxone reports at the state‐ and national‐level were calculated.ResultsThere were 304 249 cases reporting naloxone therapy during the study period. The frequency of naloxone reports increased from 9498 in 2000 to 26 826 in 2016. The proportion of cases where naloxone was used prior to PC recommendation increased from 59.8% in 2000 to 81.5% in 2016. The mean number of NPDS naloxone reports per 100 000 human exposures increased from 9.6 [95% confidence interval (CI) = 6.4–14.2] to 31.7 (95% CI = 21.4–46.9, P < 0.001). Among the cases, 52.4% were female and the most frequent age group was 20–39 years (39.1%). The principal reason for a toxic exposure resulting in a naloxone report was suspected suicide (55.0%). Life‐threatening symptoms were seen in one‐fifth of the cases, with 53.9% cases being admitted to critical care units. Opioids (59.7% cases), were the most commonly reported exposure agents, with hydrocodone being most frequently reported. The national CIR of naloxone reports to the US PCs was 6.3 cases per 100 000 population, with West Virginia demonstrating the highest incidence.ConclusionsAnalysis of calls to the United States poison centers indicates an increasing trend of naloxone use from 2000 to 2016.
The Brief Intervention Effect of Metaphorical Cognitive Restructuring on Alleviating Mental Distress: A Randomised Controlled Experiment
Authors: Hu Jinghan , Zhang Wencai , Zhang Jianxin , Yu Fei , Zhang Xiaoyu 
Published: July 2018

BackgroundMetaphors may provide clarity or identify hidden similarities between two ideas, and their use in cognitive restructuring can help maximise the effect of therapy information. This study aimed to determine whether metaphorical cognitive restructuring would produce a greater intervention effect in targeted mood and cognition than non‐metaphorical restructuring.MethodsEighty‐eight participants chose 25 problems of interest and wrote a self‐report distress problem and were then randomly divided into a metaphorical restructuring group (N= 29), a literal restructuring group (N= 30), or a no restructuring problem restating group (N= 29). Participants first read a description of psychological distress (“problem”) and then read a solution within one micro‐counseling scenario. They were asked to evaluate their insightfulness during the intervention and evaluated mental distress and self‐efficacy before and after the intervention.ResultsThe mental distress of the metaphorical restructuring group significantly decreased after the intervention. Further, this group had greater insightfulness during the intervention, and this insightfulness could predict the reduction of negative affect after the intervention.ConclusionsThe use of metaphors can be of great value in eliciting a salient cognitive restructuring process and in alleviating mental distress.
Genetic correlations between body weight, scrotal circumference and visual evaluation scores in Bos indicus cattle
Authors: Abreu Luíza R. A. , Martins Paulo G. M. A. , Mota Lúcio F. M. , Ferreira Talita A. , Ribeiro Virgínia M. P. , Villela Severino D. J. , Merlo Fernanda A. , Pires Aldrin V. 
Published: July 2018

AbstractThe objective was to estimate genetic correlations between body weight (BW), scrotal circumference and visual evaluation scores of body conformation measured at standard ages in Guzerat cattle. All measurements were performed at 205 (weaning age), 365, 450 and 550 days of age; for BW, two additional measurements (at birth and 120 days of age) were realized. The data utilized in this study were retrieved from a database of the Brazilian Association of Zebu Breeders that contained information of registered Guzerat animals born between 1970 and 2013. Genetic parameters were estimated in bi‐trait analyses by using Bayesian inference. Genetic correlations between BW at 205 and 450 days of age with other traits were high and positive, whereas the correlations between visual evaluation scores with other traits were moderate. Based on correlations herein obtained, we conclude that selection based on BW results in increased visual scores and scrotal circumference, leading to improvements in productive performance and animals with best body conformation.
In vivo CYP3A4 activity does not predict the magnitude of interaction between itraconazole and tacrolimus from an extended release formulation
Authors: Vanhove Thomas , Annaert Pieter , Knops Noël , de Loor Henriëtte , de Hoon Jan , Kuypers Dirk R J 
Published: July 2018

AbstractThe magnitude of interaction between the CYP3A4 substrate tacrolimus and various CYP3A4 inhibitors is highly unpredictable. We investigated whether an individual's baseline in vivo CYP3A4 activity, assessed using the oral midazolam (MDZ) probe, could be used to predict the magnitude of drug–drug interaction between tacrolimus and the potent CYP3A4 inhibitor itraconazole. In a prospective single‐arm open‐label study, 16 healthy volunteers were administered single doses of MDZ and tacrolimus before and after a 4‐day course of itraconazole. Itraconazole treatment resulted in a 9.0‐fold decrease in MDZ apparent oral clearance (CL/F) and a 3.3‐fold decrease in tacrolimus CL/F (P < 0.001 for each). MDZ CL/F and tacrolimus CL/F were positively correlated both at baseline (r = 0.582, P = 0.018) and after itraconazole (r = 0.811, P < 0.001). Furthermore, baseline MDZ CL/F was positively correlated to the fold change in MDZ CL/F resulting from CYP3A4 inhibition (r = 0.759, P = 0.001). However, no predictors of change in tacrolimus CL/F resulting from CYP3A4 inhibition were identified, including baseline MDZ CL/F (P = 0.453), baseline tacrolimus CL/F (P = 0.759) and fold change in MDZ CL/F between both phases (P = 0.274). In conclusion, baseline oral MDZ clearance does not predict the magnitude of interaction between tacrolimus and itraconazole.
The role of within‐class consensus on mastery goal structures in predicting socio‐emotional outcomes
Authors: Bardach Lisa , Lüftenegger Marko , Yanagida Takuya , Schober Barbara , Spiel Christiane 
Published: July 2018

BackgroundWithin‐class consensus on mastery goal structures describes the extent to which students agree in their perceptions of mastery goal structures. Research on (work) teams suggests that higher levels of consensus within a group indicate a well‐functioning social environment and are thus positively related to beneficial socio‐emotional outcomes. However, the potential of within‐class consensus to predict socio‐emotional outcomes has not yet been explored in research on mastery goal structures.AimsThis study aimed to test whether within‐class consensus on the three mastery goal structures dimensions of task, autonomy, and recognition/evaluation has predictive power for socio‐emotional outcomes in terms of classroom climate, negative classmate reactions to errors, and cooperative learning.SampleA total of 1,455 Austrian secondary school students (65.70% female) in 157 classrooms participated in this study.MethodsStudents responded to items measuring their perceptions of mastery goal structures, classroom climate, error climate, and cooperative learning. Items assessing mastery goal structures, error climate, and cooperative learning referred to the subject of mathematics and items assessing classroom climate referred to positive classmate relations without focusing on a subject.ResultsResults from multilevel structural equation models revealed that within‐class consensus on all mastery goal structures dimensions predicted a less negative error climate. Additionally, consensus regarding task and autonomy predicted more frequent use of cooperative learning strategies, and consensus regarding task predicted a more positive classroom climate.ConclusionsOur findings show that higher levels of within‐class consensus on mastery goal structures enhance beneficial socio‐emotional outcomes. Moreover, the results emphasize the value of expanding the scope of educational research to the study of within‐class consensus.
Analysis of cabazitaxel‐resistant mechanism in human castration‐resistant prostate cancer
Authors: Hongo Hiroshi , Kosaka Takeo , Oya Mototsugu 
Published: July 2018

AbstractCabazitaxel (CBZ) is approved for docetaxel‐resistant castration‐resistant prostate cancer (CRPC). However, efficacy of CBZ for CRPC is limited and there are no effective treatments for CBZ‐resistant CRPC. In order to investigate the CBZ‐resistant mechanism, the establishment of a CBZ‐resistant cell line is urgently needed. We established CBZ‐resistant CRPC cell lines DU145CR and PC3CR by incubating DU145 and PC3 cells with gradually increasing concentrations of CBZ for approximately 2 years. We analyzed the gene expression profiles and cell cycle changes using microarray and flow cytometry. Pathway analysis revealed DU145CR cells had enhanced gene clusters of cell division and mitotic nuclear division. Enhancement of ERK signaling was detected in DU145CR cells. DU145CR cells had resistance to G2/M arrest induced by CBZ through ERK signaling activation. The MEK inhibitor PD184352 significantly inhibited cell proliferation of DU145CR. In contrast to DU145CR, PC3CR cells had enhancement of PI3K/AKT signaling. The PI3K/mTOR inhibitor NVP‐BEZ 235 had a significant antitumor effect in PC3CR cells. Cabazitaxel ‐resistant CRPC cells established in our laboratory had enhancement of cell cycle progression signals and resistance to G2/M arrest induced by CBZ. Enhancement of ERK signaling or PI3K/AKT signaling were detected in the cell lines, so ERK or PI3K/AKT could be therapeutic targets for CBZ‐resistant CRPC.