bluuebunny/crossref_metadata_2025_split huggingface dataset:
Multi‐omics analysis points to altered platelet functions in severe food‐associated respiratory allergy
Authors: Obeso David , Mera‐Berriatua Leticia , Rodríguez‐Coira Juan , Rosace Domenico , Fernández Paloma , Martín‐Antoniano Isabel Adoración , Santaolalla Marcela , Marco Martín Guadalupe , Chivato Tomás , Fernández‐Rivas Montserrat , Ramos Tania , Blanco Carlos , Alvarado María I. , Domínguez Carmen , Angulo Santiago , Barbas Coral , Barber Domingo , Villaseñor Alma , Escribese María M. 
Published: July 2018

AbstractBackgroundPrevalence and severity of allergic diseases have increased worldwide. To date, respiratory allergy phenotypes are not fully characterized and, along with inflammation progression, treatment is increasingly complex and expensive. Profilin sensitization constitutes a good model to study the progression of allergic inflammation. Our aim was to identify the underlying mechanisms and the associated biomarkers of this progression, focusing on severe phenotypes, using transcriptomics and metabolomics.MethodsTwenty‐five subjects were included in the study. Plasma samples were analyzed using gas and liquid chromatography coupled to mass spectrometry (GC‐MS and LC‐MS, respectively). Individuals were classified in four groups—“nonallergic,” “mild,” “moderate,” and “severe”—based on their clinical history, their response to an oral challenge test with profilin, and after a refinement using a mathematical metabolomic model. PBMCs were used for microarray analysis.ResultsWe found a set of transcripts and metabolites that were specific for the “severe” phenotype. By metabolomics, a decrease in carbohydrates and pyruvate and an increase in lactate were detected, suggesting aerobic glycolysis. Other metabolites were incremented in “severe” group: lysophospholipids, sphingosine‐1‐phosphate, sphinganine‐1‐phosphate, and lauric, myristic, palmitic, and oleic fatty acids. On the other hand, carnitines were decreased along severity. Significant transcripts in the “severe” group were found to be downregulated and were associated with platelet functions, protein synthesis, histone modification, and fatty acid metabolism.ConclusionWe have found evidence that points to the association of severe allergic inflammation with platelet functions alteration, together with reduced protein synthesis, and switch of immune cells to aerobic glycolysis.
Veno‐Arterial ECMO Weaning Failure in the Operating Room: Have You Considered Preweaning Bronchoscopy?
Authors: Luedi Markus , Friess Jan‐Oliver , Erdoes Gabor 
Published: July 2018

AbstractCurrent guidelines on postcardiotomy veno‐arterial extracorporeal oxygenation ECMO (vaECMO) do not mention the assessment of pulmonary function, especially prior to the weaning procedure in the operation room (OR). Mucociliary dysfunction, a nearly ubiquitous finding among mechanically ventilated patients, might put these patients at risk for potential airway problems and associated weaning failure at the time of vaECMO weaning in the OR. In conformity to veno‐venous ECMO management, we suggest routine bronchoscopy with bronchial hygiene in the ICU prior to vaECMO weaning in the OR. Likewise, an assessment of patient pleura for effusions should be routinely performed. Although cardiac and respiratory failure often co‐exist and there are multiple causes of respiratory failure in patients who require vaECMO, we anticipate that vaECMO patients would significantly benefit from an expanded focus on the pulmonary function and possible respiratory mucous congestion. A routine preweaning bronchoscopy would reduce the frequency of weaning failures in this particular setting, especially in those patients with successfully restored cardiac function.
Expression of CD56 defines a distinct subgroup in childhood T‐ALL with inferior outcome. Results of the ALL‐BFM 2000 trial
Authors: Fuhrmann Stephan , Schabath Richard , Möricke Anja , Zimmermann Martin , Kunz Joachim B. , Kulozik Andreas E. , Ludwig Wolf‐Dieter , Schrappe Martin , Karawajew Leonid , Ratei Richard 
Published: July 2018

SummaryThis study reports the prognostic impact of the expression of the natural killer cell marker CD56 in a large series of risk‐adapted paediatric patients with T cell acute lymphoblastic leukaemia (T‐ALL; n = 493) treated within the ALL‐Berlin‐Frankfurt‐Münster (BFM) 2000 protocol. The immunophenotype was analysed centrally at diagnosis using flow cytometry and correlated with clinical parameters and outcome. CD56 expression was detected in 7·1% and early T‐cell precursor (ETP) phenotype in 6·7% of all T‐ALL patients. The percentage of ETP in the CD56+ T‐ALL cohort was 4‐fold higher than in the whole cohort. CD56+ T‐ALL frequently expressed the progenitor marker CD34 and myeloid antigens CD13 and CD33. The 5‐year event‐free survival (EFS) rates for the European Group for the Immunological classification of Leukaemias/World Health Organization subgroups and the ETP phenotype were not statistically different. By contrast, patients with CD56 expression had a significantly reduced EFS (60 ± 8%) and overall survival (60 ± 8%) at 5 years, with a hazard ratio of 2·46 (P = 0·002) and 2·99 (P < 0·001), respectively. Moreover, CD56 expression in combination with the minimal residual disease (MRD)‐based high risk assignment defined a population with a ‘very‐high’ risk probability of relapse in the ALL‐BFM 2000 trial. The CD56 marker has the potential to augment MRD‐based risk stratification and may serve as a molecular target for antibody‐based treatment strategies in childhood T‐ALL.
Low incidence of symptomatic osteonecrosis after allogeneic HSCT in children with high‐risk or relapsed ALL – results of the ALL‐SCT 2003 trial
Authors: Kuhlen Michaela , Bader Peter , Sauer Martin , Albert Michael H. , Gruhn Bernd , Güngör Tayfun , Kropshofer Gabriele , Lang Peter , Lawitschka Anita , Metzler Markus , Pentek Falk , Rossig Claudia , Schlegel Paul G. , Schrappe Martin , Schrum Johanna , Schulz Ansgar , Schwinger Wolfgang , von Stackelberg Arend , Strahm Brigitte , Suttorp Meinolf , Luettichau Irene Teichert‐von , Wößmann Wilhelm , Borkhardt Arndt , Meisel Roland , Poetschger Ulrike , Glogova Evgenia , Peters Christina 
Published: July 2018

SummaryOsteonecrosis (ON) was prospectively assessed in 557 children and adolescents in the Berlin‐Frankfurt‐Münster Stem Cell Transplantation in children with acute lymphoblastic leukaemia 2003 trial. Median age at haematopoietic stem cell transplantation (HSCT) was 10·3 years (range 0·5–26). Cumulative incidence of symptomatic ON (sON) was 9% at 5 years (standard deviation 1%), median time from HSCT to diagnosis of sON was 12·4 months (range 1–126). Multivariate analysis identified age at HSCT [10–15 years vs. <10 years: hazard ratio (HR) 3·73, P = 0·009; >15 years vs. <10 years: HR 5·46, P = 0·001], diagnosis of sON prior to HSCT and chronic graft‐versus‐host disease (yes versus no: HR 2·696, P = 0·015) as significant independent risk factors for the development of sON.
Balancing between caregiving and professionalism—Women's narratives on fostering a victim of maternal sexual abuse
Authors: Wubs Dorijn , Batstra Laura , Grietens Hans 
Published: July 2018

AbstractThe impact of sexual abuse on children is enormous, particularly when a child is abused sexually by a mother figure. In order to gain insight into the experiences of this rarely studied group, the life stories of four foster mothers of victims of maternal sexual abuse were collected. The narratives were coded inductively, and several topics concerning foster motherhood were studied more in‐depth. Four key themes emerged in the women's narratives: their attitude towards the abusing female, the foster child's sexual behaviour towards the foster mother, the emotional and physical distance of the foster mothers towards their foster child, and lastly, their sense of responsibility. The four foster mothers continuously balance between fostering their foster child as a parent and responding as a professional caregiver. The consequences of being a foster mother of a victim of maternal sexual abuse should be more socially acknowledged.
The least‐cost biodiversity impact mitigation hierarchy with a focus on marine fisheries and bycatch issues
Authors: Squires Dale , Garcia Serge 
Published: July 2018

AbstractLeast‐cost implementation of the mitigation hierarchy of impacts on biodiversity minimizes the cost of a given level of biodiversity conservation, at project or ecosystem levels, and requires minimizing costs across and within hierarchy steps. Incentive‐based policy instruments that price biodiversity to alter producer and consumer behavior and decision making are generally the most effective way to achieve least‐cost implementation across and within the different hierarchy steps and across all producers and conservation channels. Nonetheless, there are circumstances that favor direct regulation or intrinsic motivation. Conservatory offsets, introduced within the conservatory first three steps of the mitigation hierarchy, rather than the fourth step to compensate the residual, provide an additional incentive‐based policy instrument. The least‐cost mitigation hierarchy framework, induced through incentive‐based policy instruments, including conservatory offsets, mitigates fisheries bycatch consistent with given targets, the Law of the Sea, and the Convention on Biological Diversity.
Non‐oxidative hair dye products on the European market: What do they contain?
Authors: Hedberg Yolanda S. , Uter Wolfgang , Banerjee Piu , Lind Marie‐Louise , Skovvang Steengaard Sanne , Teo Ying , Lidén Carola 
Published: July 2018

BackgroundHair dyeing is very common and may cause allergic contact dermatitis. Oxidative (often termed permanent or semi‐permanent) hair dye products have constituted the focus of market surveys and toxicological risk assessments, while non‐oxidative (semi‐permanent, temporary or direct) products have not been assessed.ObjectivesTo identify the hair dye substances presently used in non‐oxidative hair dye products in Europe.MethodsIngredient label data on eligible products in 5 European countries were collected, and 289 different non‐oxidative hair dye products were included in this study.ResultsUp to 9 hair dye substances were present in each product. Sixty‐eight individual hair dye substances were identified on the 289 product labels, and their occurrence ranged from 0.3% to 34%. There were differences concerning substances used and their number per product between products of different consistency and colour.ConclusionsThe hair dye substances in non‐oxidative hair dye products are different from those in oxidative hair dye products, and are currently not covered by patch test series. The toxicological and skin‐sensitizing profile of the substances in non‐oxidative hair dye products, as well as their concentrations, should be further investigated.
MiR‐616‐3p modulates cell proliferation and migration through targeting tissue factor pathway inhibitor 2 in preeclampsia
Authors: Xu Yetao , Wu Dan , Jiang Ziyan , Zhang Yuanyuan , Wang Sailan , Ma Zhonghua , Hui Bingqing , Wang Jing , Qian Weiping , Ge Zhiping , Sun Lizhou 
Published: July 2018

AbstractObjectivesDespite improvements in diagnosis and treatment, preeclampsia (PE) continues to pose a significant risk of maternal and foetal morbidity and mortality if not addressed promptly. An increasing number of studies have suggested that tissue factor pathway inhibitor 2 (TFPI2) acts as a suppressor gene, possibly inhibiting multiple serine proteases affecting cell proliferation and migration. It plays an essential role in the occurrence and development of PE, but the pathogenesis remains unclear.Materials and methodsIn our research, we performed western blotting, immunohistochemistry and qPCR assays to investigate TFPI2 and miR‐616‐3p expression in preeclamptic placental tissues. Cell assays were performed in HTR‐8/SVneo and JEG3 cell lines. Cell proliferation and migration events were investigated by MTT, EdU and transwell assays. In conjunction with bioinformatics analysis, luciferase reporter assays were performed to elucidate the mechanism by which miR‐616‐3p binds to TFPI2 mRNA.ResultsWe established that TFPI2 protein levels were significantly upregulated in PE placental tissues. In addition, we found that miR‐616‐3p binds specifically to the 3′‐UTR region of TFPI2 mRNA. Furthermore, miR‐616‐3p knockdown or TFPI2 overexpression substantially impaired cell growth and migration, whereas miR‐616‐3p upregulation or TFPI2 knockdown stimulated cell proliferation and migration. This miR‐616‐3p/TFPI2 axis was also found to affect the epithelial‐mesenchymal transition process in PE.ConclusionsOur results demonstrated that TFPI2 plays a vital role in the progression of PE and might provide a prospective therapeutic strategy to mitigate the severity of the disorder.
Methods for calculation of per capita alcohol consumption in a Muslim majority country with a very low drinking level: Findings from the 2011 Iranian mental health survey
Authors: Amin‐Esmaeili Masoumeh , Motevalian Abbas , Hajebi Ahmad , Sharifi Vandad , Stockwell Tim , Rahimi‐Movaghar Afarin 
Published: July 2018

AbstractIntroduction and AimsThere is a paucity of data on volume of alcohol use from Muslim majority countries. We aimed to present estimation methods for alcohol consumption with the use of survey data for these societies and provide an estimation for age 15+ per capita consumption of pure alcohol for Iran.Design and MethodsThe Iranian Mental Health Survey was a nationally representative household survey on individuals aged 15–64 years, with a multistage, cluster sampling design. We used the ‘Last Week’ method and ‘Quantity‐Frequency’ methods for gathering data on alcohol consumption and combined these to provide more complete estimates.ResultsThe response rate was 85.7%. From the total of 7840 respondents, 5.7% and 1% reported past 12 months and past week alcohol use, respectively. The highest estimation for age 15+ per capita consumption of pure alcohol was yielded by the ‘combination method’ (0.108 L ethanol/person/year) followed by the Quantity‐Frequency method (0.079 L). The ‘Last Week’ method provided the lowest estimate (0.059 L).Discussion and ConclusionsUnlike in surveys of non‐Muslim countries, frequency of drinking from recent recall (last week) was much lower than from recall of usual drinking in the last year. We conclude that 0.108 L (SE = 0.03) is the best survey‐based estimate of age 15+ per capita consumption, which translates to about 5 750 000 L of national consumption per year in Iran. However, this method is still likely to under‐estimate per capita consumption due to evidence of under‐reporting in the survey.
Sleep deprivation and melatonin for inducing sleep in paediatric electroencephalography: a prospective multicentre service evaluation
Authors: Alix James J P , Kandler Rosalind H , Pang Catherine , Stavroulakis Theocharis , Catania Santiago 
Published: July 2018

AimTo compare the efficacy of the main methodologies in attaining sleep and electroencephalography (EEG) abnormalities in children with a view to producing recommendations on best practice.MethodFifty‐one UK centres participated. Methods for sleep induction (sleep deprivation, melatonin, and combined sleep deprivation/melatonin) were compared. Data pertaining to demographics, achievement of stage II sleep, and recording characteristics (duration of study, presence of epileptiform activity in awake/sleep states) were prospectively collected for consecutive patients in November and December 2013.ResultsFive hundred and sixty‐five patients were included. Age range was 1 years to 17 years (mean 7y 10mo), 27.7 per cent had an underlying neurobehavioural condition. Stage II sleep was achieved in 69 per cent of sleep deprived studies, 77 per cent of melatonin studies, and 90 per cent of combined intervention studies (p<0.001, χ2). In children who slept, there was no difference between the three interventions in eliciting epileptiform discharges. In children who did not sleep, epileptiform abnormalities were seen more often than after sleep deprivation alone (p=0.02, χ2). Seizures were rare.InterpretationCombined sleep deprivation/melatonin is more effective than either method alone in achieving sleep. The occurrence of epileptiform activity during sleep is broadly similar across the three groups. We recommend the combined intervention to induce sleep for paediatric EEG.What this paper adds

Combined sleep deprivation/melatonin is more effective in achieving sleep than either sleep deprivation or melatonin alone.

Sleep latency is shorter with combined sleep deprivation/melatonin.

When children do sleep, there is no difference in the occurrence of epileptiform abnormalities between different induction methods.

Seizures are rare in sleep electroencephalography recordings.
Long‐term clinical outcomes of patients with hematologically unexplained cytopenia after routine assessment: A single center study
Authors: Johansen Morten Munk , Andersen Michael Asger , Grønbæk Kirsten , Hansen Jakob Werner 
Published: July 2018

AbstractObjectiveWe investigated mortality and long‐term development of malignant hematological disease, cancer, liver‐, renal‐, and rheumatic disease in patients with unexplained cytopenia (UC).MethodsWe screened all patients referred to the outpatient clinic at the Department of Hematology, Rigshospitalet, Copenhagen, with a suspected myeloid neoplasm from June 2009 to the end of 2012. Through registry linkage, we obtained information on hospital‐based ICD‐10 diagnoses and survival. We estimated cumulative incidences of disease and hazard ratios of all‐cause mortality using the Aalen‐Johansen estimator and Cox regression. We compared incidences and mortality with a control cohort.ResultsAmong 1820 referrals, 221 had UC. The UC group had a 5‐year cumulative incidence of malignant hematological disease of 8.91% (CI 95%: 4.98‐12.84) compared to 0.93(CI 95%: 0.32‐1.55) in the matched controls. In addition, UC patients had higher incidences of cancer, liver, and rheumatic disease. Mortality was higher in UC patients compared to the matched controls with a HR of 1.43 [P = 0.038, CI 95%: 1.02‐2.00] adjusted for comorbidity, sex, and age. Most of the mortality and morbidity were ascribed to patients 50 years or older.ConclusionsUnexplained cytopenia patients had a higher incidence of malignant hematological‐, cancer‐, liver‐, and rheumatic disease and increased mortality compared to the general population.
Multiple data sources and freely available code is critical when investigating species distributions and diversity: a response to Knouft (2018)
Authors: Dallas Tad , Decker Robin R , Hastings Alan 
Published: July 2018

AbstractA recent comment from Knouft () has suggested that our original article (Dallas et al. ) was an ‘inappropriate application of biodiversity data’. Here, we affirm our results, and address the more general point about biodiversity data use.
Spawning patterns provide further evidence for multiple stocks of sardine (Sardinops sagax) off eastern Australia
Authors: Sexton Stuart C. , Ward Tim M. , Stewart John , Swadling Kerrie M. , Huveneers Charlie 
Published: July 2018

AbstractPrevious studies have suggested that sardine, Sardinops sagax, off eastern Australia spawns across its entire range when habitat conditions are suitable. However, recent studies have suggested that separate sub‐populations and spawning groups may occur in the region. Spawning patterns off eastern Australia were investigated using data collected during nine ichthyoplankton surveys conducted between 1997–2015, and adult reproductive data obtained from ad hoc commercial sampling off New South Wales (NSW). The egg surveys covered the known distribution of sardine off eastern Australia and included year‐round sampling in the northern and southern parts of this range. Egg distributions and analysis of gonadosomatic indices identified two spatio‐temporally separate spawning groups; one occurring off southern Queensland to northern NSW during late winter and early spring, and a smaller group off eastern Tasmania to southern NSW during summer. Most eggs were collected from waters 50–90 m deep, with sea surface temperatures of 18–23°C. Additive modelling indicated depth was the most significant factor driving selection of spawning habitat, followed by the interaction of month and latitude. Low egg densities were recorded in waters between 34–37°S, despite conditions within the ranges suitable for spawning. The presence of two spawning groups of sardine off eastern Australia supports recent findings that two sub‐populations occur in the region. Findings of this study will help to optimise the spatio‐temporal extent of future egg surveys and further confirm the need to coordinate future management of each sub‐population among relevant jurisdictions.
New directions in the historiography of the administration of the Bloody Code
Authors: Walliss John 
Published: July 2018

AbstractIn this article, I will review the recent historiography of the administration of the so‐called Bloody Code of the long eighteenth century. The 1970s and 1980s witnessed a debate among Marxist historians and others over the extent to which the Bloody Code operated as a tool of the ruling elite to protect property interests. In recent years, however, several historians have begun to explore a different series of questions in regard to the Bloody Code. One theme that unites the current work is an emphasis on the variability of the Bloody Code. In the article, I discuss three areas of variability highlighted by this work: time, geography, and judicial decision‐making.
A study on gender differences in newly detected leprosy cases in Sichuan, China, 2000–2015
Authors: Liu Yang‐Ying , Yu Mei‐Wen , Ning Yong , Wang Hao 
Published: July 2018

AbstractBackgroundMany researches on gender differences in leprosy found that female patients were detected with the disease later and had more serious disabilities than male patients. We analyzed the gender differences related to epidemiological characteristics of new leprosy cases detected from 2000 to 2015 in Sichuan Province, China.MethodsA retrospective study was undertaken to analyze the gender differences with respect to age, delay in disease detection, the main modes of detection, and disability grade. The chi‐squared test and t test were applied for the comparison using Epi Info 7.2 with a significance level of a = 0.05. The data were collected from the Leprosy Management Information System in China.ResultsA total of 2900 new leprosy cases were detected from 2000 to 2015, of whom 2075 (71.6%) were male and 825 (28.4%) were female with a gender ratio of 2.5. The gender ratio of patients aged 15–30 was significantly lower than that of patients aged 31–45 and 46–60. Male cases were older than female cases when they were detected. The proportion of Grade 2 Disability (G2D) among men (20.6%) was significantly higher than that among women (17.3%). The average period of delay in detection among male cases was similar with that among females cases.ConclusionsGender‐related differences existed among the leprosy cases detected from 2000 to 2015. Female patients were younger than male patients. The detection of leprosy in women was not later than in the case of men. The disability situation in men was more serious than in women.