bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dual prognostic role of 2‐oxoglutarate‐dependent oxygenases in ten cancer types: implications for cell cycle regulation and cell adhesion maintenance
Authors: Chang Wai Hoong , Forde Donall , Lai Alvina G. 
Published: April 2019

AbstractBackgroundTumor hypoxia is associated with metastasis and resistance to chemotherapy and radiotherapy. Genes involved in oxygen‐sensing are clinically relevant and have significant implications for prognosis. In this study, we examined the pan‐cancer prognostic significance of oxygen‐sensing genes from the 2‐oxoglutarate‐dependent oxygenase family.MethodsA multi‐cohort, retrospective study of transcriptional profiles of 20,752 samples of 25 types of cancer was performed to identify pan‐cancer prognostic signatures of 2‐oxoglutarate‐dependent oxygenase gene family (a family of oxygen‐dependent enzymes consisting of 61 genes). We defined minimal prognostic gene sets using three independent pancreatic cancer cohorts (n = 681). We identified two signatures, each consisting of 5 genes. The ability of the signatures in predicting survival was tested using Cox regression and receiver operating characteristic (ROC) curve analyses.ResultsSignature 1 (KDM8, KDM6B, P4HTM, ALKBH4, ALKBH7) and signature 2 (KDM3A, P4HA1, ASPH, PLOD1, PLOD2) were associated with good and poor prognosis. Signature 1 was prognostic in 8 cohorts representing 6 cancer types (n = 2627): bladder urothelial carcinoma (P = 0.039), renal papillary cell carcinoma (P = 0.013), liver cancer (P = 0.033 and P = 0.025), lung adenocarcinoma (P = 0.014), pancreatic adenocarcinoma (P < 0.001 and P = 0.040), and uterine corpus endometrial carcinoma (P < 0.001). Signature 2 was prognostic in 12 cohorts representing 9 cancer types (n = 4134): bladder urothelial carcinoma (P = 0.039), cervical squamous cell carcinoma and endocervical adenocarcinoma (P = 0.035), head and neck squamous cell carcinoma (P = 0.038), renal clear cell carcinoma (P = 0.012), renal papillary cell carcinoma (P = 0.002), liver cancer (P < 0.001, P < 0.001), lung adenocarcinoma (P = 0.011), pancreatic adenocarcinoma (P = 0.002, P = 0.018, P < 0.001), and gastric adenocarcinoma (P = 0.004). Multivariate Cox regression confirmed independent clinical relevance of the signatures in these cancers. ROC curve analyses confirmed superior performance of the signatures to current tumor staging benchmarks. KDM8 was a potential tumor suppressor down‐regulated in liver and pancreatic cancers and an independent prognostic factor. KDM8 expression was negatively correlated with that of cell cycle regulators. Low KDM8 expression in tumors was associated with loss of cell adhesion phenotype through HNF4A signaling.ConclusionTwo pan‐cancer prognostic signatures of oxygen‐sensing genes were identified. These genes can be used for risk stratification in ten diverse cancer types to reveal aggressive tumor subtypes.
Off-label use of ketamine for treatment-resistant depression in clinical practice: European perspective
Authors: López-Díaz Álvaro , Murillo-Izquierdo Manuel , Moreno-Mellado Elisa 
Published: April 2019

SummaryKetamine therapy for treatment-resistant depression in European national health systems may only be considered after attempting all evidence-based antidepressant strategies outlined in clinical guidelines. This paper seeks to explain the ethical, regulatory and procedural framework for the off-label use of ketamine for treatment-resistant depression within a public healthcare system.Declaration of interestNone.
Determination of Gamma Rays Efficiency Against Rhizoctonia solani in Potatoes
Authors: Kara Aslı , Arici Şerife Evrim 
Published: April 2019

AbstractThere are many diseases in potatoes that cause loss of quality and yield in the world. One of them is the Rhizoctonia stem canker and black scurf of potato caused by Rhizoctonia solani (telemorph: Thanetephorus cucumeris). Disease resistant plants can be generated by irradiated application. By irradiating the plant explants, some radicals and biochemical compounds can be generated in cells. In this study, in-vitro cultured expiants from potato cv. Alonso were irradiated with gamma rays with five different doses (22, 33, 54, 57 and 109 Gy). After four sub-cultures in MS media, irradiated plants were inoculated with Rhizoctonia solani and potato plants were cultured at 24 ± 1°C in climate room conditions. The survival rates of the plants were determined after 15 days. Some parameters such as plant size, leaf number and number of plant nodes were recorded and compared with control groups. The highest survival rate of the plants (42%) was determined at 22 Gy and 109 Gy doses (42%) and the lowest survival rate of plants (20%) was determined in the positive control group (P<0.05). The highest number of plant nodes and number of leafs were determined at 54 Gy doses and maximum plant size was determined at 109 Gy doses.
Dynamic assessment of the pupillary reflex in patients on high-dose opioids
Authors: Kongsgaard Ulf E. , Høiseth Gudrun 
Published: April 2019

Abstract

Background and aims
Pupil size and reaction are influenced by opioids, an effect that is not considered to be affected by opioid tolerance. As clinicians have observed patients on high-dose opioids who exhibited seemingly normal pupil sizes, we wanted to dynamically assess the pupillary reflex in cancer patients on high-dose opioids.

Methods
We performed a dynamic assessment of the pupillary reflex in cancer patients on high-dose opioids and a control group of healthy volunteers using a portable, monocular, infrared pupillometer. We also performed a clinical examination and measured blood concentrations of opioids and their active metabolites.

Results
Sixty three patients who were on opioids for 2 months (median time) and on an oral morphine equivalent dose of 250 mg (median dose) were investigated. Most patients used more than one opioid. When correcting for age, pupil size in the group that had received no increase of opioid dose over the last 14 days was not significantly different from pupil size in the healthy volunteer group (p = 0.76), while the group that had increased the dose of opioids differed significantly from healthy volunteers (p = 0.006). We found no statistically significant correlation between total oral morphine equivalents and pupillary reactions or between blood opioid or opioid metabolite concentrations and baseline pupillary changes.

Conclusion
Pupillary changes do take place in patients on opioids. However, tolerance to these changes occurs when medication is not increased over time. Dynamic pupillometry can give additional information about the degree of tolerance to opioids.

Implications
These findings elucidate previous misconceptions regarding pupillary effects and tolerance to opioids.
Research on digital news distribution based on cognitive neuroscience
Authors: Zheng Xiaomei 
Published: April 2019

Abstract
Updated computer and brain science have profoundly changed journalism and communication as well as the media industry. The application of related technologies and theories represented by big data technology, cognitive neuroscience and intelligent technology may bring about a paradigmatic shift in journalism and communication. On the basis of combing the frontier development of cognitive neuroscience at home and abroad, this paper introduces the cases of applying the cognitive neurological method in communication studies and studies the application situation of the communicating effect in the field of advertising, photos, news webs, and films and television. This paper also discusses the important significance of relevant frontier results for the development of journalism and communication discipline.
Išmintis lietuvio pasaulėvaizdyje
Authors: Smetonienė Irena , Ganusauskaitė Beatričė 
Published: April 2019

[straipsnis ir santrauka lietuvių kalba; santrauka anglų kalba]
Straipsnyje Liublino etnolingvistų sukurtu kognityvinės definicijos metodu siekiama ištirti lietuviškąją išmintį ir jos vietą vertybių sistemoje. Pirma, nagrinėjami įvairiuose lietuvių kalbos žodynuose pateikiami žodžio išmintis ir jo vedinių straipsniai. Toliau aprašoma atlikta apklausa, atskleidžianti šių laikų jauno žmogaus suvokimą. Galiausiai tiriami šeši diskursai, apibrėžiantys išmintį kaip daugiaplanę sąvoką. Pabaigoje pateikiama kognityvinė definicija, žyminti, kaip lietuvių tautos suvokiama, vertinama, kaip apibūdinama ir su kuo siejama išmintis.
Socioeconomic Disadvantage in Infancy and Academic and Self-Regulation Outcomes
Authors: O’Connor Meredith , Chong Shiau , Hutchinson Delyse , Sanson Ann , McIntosh Jennifer , Olsson Craig A. , Goldfeld Sharon 
Published: April 2019

OBJECTIVES:A comprehensive understanding of how timing of exposure to disadvantage affects long-term developmental risk is needed for greater precision in child health policy. We investigated whether socioeconomic disadvantage in infancy (age 0–1 years) directly affects academic and self-regulation problems in late childhood (age 10–12 years), independent of disadvantage at school entry (age 4–6 years).METHODS:Analyses were replicated in 2 population-based cohorts: the Australian Temperament Project (ATP; N = 2443) and the Longitudinal Study of Australian Children (LSAC; N = 5107). Generalized linear models were used to estimate the crude and adjusted effects. Marginal structural models were used to estimate the controlled direct effect of socioeconomic disadvantage in infancy on academic and self-regulation outcomes in late childhood, independent of disadvantage at school entry.RESULTS:In both cohorts, socioeconomic disadvantage in infancy and at school entry was associated with poorer academic and self-regulation outcomes. Socioeconomic disadvantage in infancy had a direct effect on academic outcomes not mediated by disadvantage at school entry (ATP: risk ratio [RR] = 1.42; 95% confidence interval [CI]: 1.09–1.86; LSAC: RR = 1.87; 95% CI: 1.52–2.31). Little evidence was found for a direct effect of disadvantage in infancy on self-regulation (ATP: RR = 1.22; 95% CI: 0.89–1.65; LSAC: RR = 1.19; 95% CI: 0.95–1.49).CONCLUSIONS:Socioeconomic disadvantage in infancy had a direct effect on academic but not self-regulation outcomes in late childhood. More precise public policy responses are needed that consider both the timing of children’s exposure to disadvantage and the specific developmental domain impacted.
Population fluctuation of fruit fly Anastrepha spp. (Diptera: Tephritidae) in guava (Psidium guajava L.) accesses produced in organic system
Authors: Galli Juliana Altafin , Michelotto Marcos Doniseti , Soares Maria Beatriz Bernardes , Martins Antônio Lucio Mello , Fischer Ivan Herman 
Published: April 2019

Guava (Psidium guajava L.) presented prominence among the tropical fruit. Guava exports are still unimpressive, because of the quarantine pests, among them the fruit flies. The present research had as objective to evaluate the population fluctuation of fruit flies Anastrepha spp. and the fruits infestation caused in guava accesses cultivated in organic system, and study the possible correlations between this pest and meteorological factors. To estimate population fluctuation, 20 yellow sticky traps were used. The reviews were initiated in April 2013, for 378 days. The traps were kept in the field for the entire duration of the experiment, and they were reviewed every 14 days in most cases, during replacement of traps for new ones. With the data, simple correlations were calculated between the fruit flies of the genus Anastrepha spp., the temperature, and precipitation. Nine fruits per accession, at the stage of maturation, were taken to the laboratory and evaluated for fruit fly infestation by the longitudinal cutting of fruit. The averages were compared by the Scott-Knott test at 5% probability. The genus Anastrepha was found in greater quantity, and there is no correlation between the meteorological factors and population fluctuation of Anastrepha. Also was found some individuals of the species Ceratitis capitata. Most of the fruits of the evaluated accesses presented high infestations by fruit flies. Accesses IAC – 4 – Cica noteworthy for not presenting any infested fruit, without differing from accesses Taquaritinga Comum, both red. The accesses Torrão de Ouro, Supreme BA, L2P4, and Supreme, also showed low numbers of fruit attacked.
Respuesta de Vigna unguiculata (L) Walp ante la aplicación de bioproductos en condiciones de huertos intensivos
Authors: Tamayo Aguilar Yonger , Riera Nelson Manuel Conrrado , Terry Alfonso Elein , Juárez López Porfirio , Rodríguez Matos Yuris 
Published: April 2019

En condiciones de huertos intensivos, ubicados en el municipio San Antonio del Sur, Cuba, entre septiembre y noviembre de 2017 se evalúo la respuesta de Vigna unguiculata (L) Walp var. Alina (habichuela) a la aplicación foliar de bioproductos. En un diseño experimental de bloques al azar con tres repeticiones fueron evaluados los tratamientos: 5 y 10 mL/L por ha de Lebame, 1.5 y 3.5 kg/ha de Spiruvinas, y una aplicación uniforme por tratamiento de Rhizophagus irregularis, más dos tratamientos de materia orgánica (M.O.) consistentes en 5 y 10 kg/m2 (testigo) sin rizobio. Las variables evaluadas fueron altura de planta, diámetro del tallo, número de vainas y rendimiento. Los mayores rendimientos y desarrollo del cultivo se encontraron con los tratamientos combinados de Lebame y Spiruvinas, especialmente con la dosis de 3.5 mL/L por ha de este último más la cepa comercial EcoMic® de Rhizophagus irregularis con rendimiento de 4.17 kg/m2.
Pesan Dakwah dalam Lirik Lagu Ebiet G. Ade
Authors: Islami Syifa Hayati 
Published: April 2019

Abid Ghoffar bin Aboe Dja'far or more familiarly called Ebiet G. Ade is a phenomenon of the many singers who embed the divine messages in the song. Ebiet tries to invite the listener to feel and see that God is very close and watching his servant. In the lyrics of this song can be taken a lesson about the core of Islamic teachings that should be known and amalkan by the Muslims that is Tawheed. Many Muslims are only limited to knowing about Tawheed, but not much more in understanding and practicing Him. This study uses a qualitative approach that is a documentary discourse that aims to explain the meaning of ketauhidan contained in the lyrics of the song Ebiet G. Ade. The lyrics of the song are "Berita kepada kawan", "Untuk kita renungkan", "Masih ada waktu", "Aku ingin pulang", dan "Kepadamu Aku Pasrah". Then analyzed using Teun A Van Dijk discourse analysis model. The results of this study, there are three kinds of Tawheed are: Tawheed Uluhiyah, Tauhid Rububiyah and Tauhid Ubudiyah. From all five songs of Ebiet G. Ade that have been analyzed that there are three songs that contain the meaning of Tawheed Ubudiyah, which is “Untuk Kita Renungkan”, “Masih Ada waktu” dan “Kepadamu Aku Pasrah” a song that contains the meaning of Tawheed Rububiyah, namely “Berita Kepada Kawan” and one song that contains the meaning of Tawheed Uluhiyah, namely “Aku Ingin Pulang”.

Abid Ghoffar bin Aboe Dja’far atau yang lebih akrab disapa Ebiet G. Ade merupakan fenomena dari sekian banyak penyanyi yang menyematkan pesan-pesan ketuhanan dalam lagunya. Ebiet mencoba mengajak pendengar untuk merasakan dan melihat bahwa Allah sangat dekat dan mengawasi hamba-Nya. Dalam lirik-lirik lagu ini dapat diambil pelajaran mengenai inti ajaran Islam yang seharusnya diketahui dan amalkan oleh kaum muslimin yaitu Tauhid. Banyak orang Islam yang hanya sebatas tahu mengenai Tauhid, namun tidak banyak yang lebih dalam memahami dan mengamalkan-Nya. Penelitian ini menggunakan pendekatan kualitatif yang bersifat wacana dokumentatif yang bertujuan untuk memaparkan makna ketauhidan yang terdapat dalam lirik lagu Ebiet G. Ade. Adapun lirik-lirik lagu tersebut adalah "Berita kepada kawan", "Untuk kita renungkan", "Masih ada waktu", "Aku ingin pulang", dan "Kepadamu Aku Pasrah". Kemudian dianalisis menggunakan model analisis wacana Teun A Van Dijk. Hasil dari penelitian ini, terdapat tiga macam Tauhid yaitu: Tauhid Uluhiyah, Tauhid Rububiyah dan Tauhid Ubudiyah. Dari keseluruhan lima lagu Ebiet G. Ade yang telah dianalisis yaitu terdapat tiga lagu yang mengandung makna Tauhid Ubudiyah, yaitu “Untuk Kita Renungkan”, “Masih Ada waktu” dan “Kepadamu Aku Pasrah” satu lagu yang mengandung makna Tauhid Rububiyah, yaitu “Berita Kepada Kawan” dan satu lagu yang mengandung makna Tauhid Uluhiyah, yaitu “Aku Ingin Pulang”.
Media Sosial Instagram sebagai Media Dakwah
Authors: Zahra Ulfa Fauzia , Sarbini Ahmad , Shodiqin Asep 
Published: April 2019

This paper discusses the main theme and kategosisasi message da'wah and the meaning of message da'wah in post account islamiposter instagram. The method used is the content analysis of post account Instagram islamiposter account. Of the total 200 posts on the account instagram islamiposter period 1 June 2016 to 30 June 2016 taken as many as 20 post samples are used as data for analysis. The results found there are messages with the category akidah a number of 4 posts, the message with the category of worship 8 postings, and messages with the category of morals 8 posts.
Tulisan ini membahas tentang tema pokok dan kategosisasi pesan dakwah serta makna pesan dakwah dalam postingan akun instagram islamiposter. Metode yang digunakan adalah analisis isi terhadap postingan akun Instagram islamiposter. Dari total 200 postingan pada akun instagram Islamiposter periode 1 Juni 2016 hingga 30 Juni 2016 diambil sebanyak 20 sampel postingan yang dijadikan sebagai data untuk dianalisis. Hasil penelitian menemukan terdapat pesan dengan kategori akidah sejumlah 4 postingan, pesan dengan kategori ibadah 8 postingan, dan pesan dengan kategori akhlak 8 postingan.
Model Radio Dakwah dalam Meningkatkan Pemahaman Keagamaan Masyarakat
Authors: Fauzi Syarif , Latief Afief Abd. 
Published: April 2019

This paper discusses the radio model of da'wah and the characteristics of radio da'wah seen from da’wah unit and its role in increasing religious understanding of audience. The object of research is Radio Fajri 99.3 FM Bogor. This research uses descriptive method with qualitative approach. Radio Fajri as a propagation radio is very important role in the development of da'wah and with the aim of improving the religious understanding of society in Bogor. Radio Fajri from its inception was influenced by technological developments, quality broadcast programs, and public interest in Islamic broadcasting. Radio Fajri is instrumental in the da'wah of Islam and the progress of religious understanding of society in Bogor. The propagation of da'wah can be successful because this radio departs from the consciousness of its founders who want the community to easily obtain information about Islam.
Tulisan ini menggambarkan model dan karakteristik radio dakwah dilihat dari unsur dakwah dalam program siarannya dan peranannya dalam meningkatkan pemahaman keagamaan masyarakat. Objek penelitian Radio Fajri 99,3 FM Bogor. Penelitian ini menggunakan metode deskriptif dengan pendekatan kualitatif. Radio Fajri sebagai radio dakwah sangat berperan penting dalam perkembangan dakwah dan dengan tujuan meningkatkan pemahaman keagamaan masyarakat di Bogor. Radio Fajri dari awal didirikan ikut dipengaruhi oleh perkembangan teknologi, program siaran yang berkualitas, dan minat masyarakat pada siaran Islami. Radio Fajri sangat berperan dalam dakwah Islam dan kemajuan perkembangan pemahaman keagamaan masyarakat di Bogor. Penyebaran dakwah bisa sukses karena radio ini berangkat dari kesadaran pendirinya yang menginginkan agar masyarakat mudah dalam mendapatkan informasi tentang Islam.
Pesan Dakwah Visual tentang Muslimah di Media Sosial Line @dakwahmuslimah
Authors: Tifany Siti Zakiyah , Fatoni Uwes 
Published: April 2019

This article discusses the message of da'wah on Muslimah in the Line @ dakwahmuslimah account both the content aspect and the form format of da'wah messages. The research method used qualitative content analysis with descriptive research type of 53 messages of da'wah uploaded account Line @dakwahmuslimah in November 2015 as many as messages. Based on the research results found that there are three message categories of da'wah, namely aqidah, syari'ah and akhlak. The format of the da'wah message include posters, memes, comics and stickers. From the format of this da'wah message found variations of content and format of visual dakwah messages, namely poster on akidah, poster on syari'ah, poster on akhlak, meme on syari'ah, comics on akidah, comics on morals and stickers on akhlak.
Artikel ini membahas pesan dakwah visual tentang muslimah dalam akun Line @dakwahmuslimah baik dari aspek konten maupun bentuk format pesan dakwah. Metode penelitian yang digunakan adalah analisis isi kualitatif dengan jenis penelitian deskriptif terhadap pesan-pesan dakwah yang diunggah akun Line @dakwahmuslimah pada bulan November 2015 sebanyak 53 pesan. Berdasarkan hasil penelitian ditemukan kategori pesan dakwah terdapat tiga, yaitu akidah, syari’ah dan akhlak. Adapun format pesan dakwah meliputi poster, meme, komik dan sticker. Dari format pesan dakwah ini ditemukan variasi konten dan format pesan dakwah visual, yaitu poster akidah, poster syari’ah dan poster akhlak, meme syari’ah, komik akidah, komik akhlak dan sticker akhlak.
Pesan Dakwah dalam Buku Humor Karya Mustofa Bisri
Authors: Ramdani Lukman , Sumijati Sitty , Nuraeni Heny Gustini 
Published: April 2019

This study aims to find out the message categories of dakwah, message organization, and appeal messages contained in the book “Canda Nabi dan Sufi Hingga Kelucuan Kita” by Mustofa Bisri. The method used in this research is content analysis with descriptive approach. This analysis is done by identifying categories, organization, and appeal messages on the book and the message category of dakwah, organization of messages, and appeal messages on each theme of the story. The results of the research found that the categories of messages contained in the book “Canda Nabi dan Sufi Hingga Kelucuan Kita” is message Akidah, Shariah, and Akhlak. The more prominent Message of Aqeedah in this book is the message of Aqeedah with a sub category of faith in God. The message organization in this book is a deductive, inductive, chronological, logical, topical, and spatial pattern. While the more dominant message organization is chronological pattern. The message implied in this book is a rational, emotional, and motivational appeal. A more dominant appeal is a rational appeal and an emotional appeal.

Penelitian ini bertujuan untuk mengetahui kategori pesan dakwah, organisasi pesan dakwah, dan imbauan pesan dakwah yang terkandung dalam buku “Dari Canda Nabi dan Sufi hingga Kelucuan Kita” Karya Mustofa Bisri. Metode yang digunakan pada penelitian ini adalah analisis isi dengan pendekatan deskriptif. Analisis ini dilakukan dengan mengidentifikasi kategori, organisasi, dan imbauan pesan pada buku dan pada tiap-tiap tema cerita. Hasil penelitian yang ditemukan menunjukan bahwa kategori pesan yang terkandung dalam buku “Dari Canda Nabi dan Sufi Hingga Kelucuan Kita” ialah pesan akidah, syariah, dan akhlak. Pesan akidah yang lebih menonjol dalam buku ini adalah pesan akidah dengan sub kategori iman kepada Allah. Organisasi pesan dalam buku ini adalah pola deduktif, induktif, kronologis, logis, topikal, dan spasial. Sedangkan organisasi pesan yang lebih dominan adalah pola kronologis. Imbauan pesan yang ada dalam buku ini adalah imbauan rasional, emosional, dan motivasional sedangkan imbauan yang lebih dominan adalah imbauan rasional dan imbauan emosional.