bluuebunny/crossref_metadata_2025_split huggingface dataset:
A structure-based model for the electrostatic interaction of the N-terminus of protein tau with the fibril core of Alzheimer’s Disease filaments
Authors: Boyer David R. , Eisenberg David S. 
Published: December 2018

AbstractAlthough portions of tau protein within the microtubule binding region have been shown to form the ordered core of tau filaments, the structural details of how other regions of tau participate in filament formation are so far unknown. In an attempt to understand how the N-terminus of tau may interact with fibril core, we crystallized and determined the structure of the N-terminal segment 5RQEFEV10 of tau. Several lines of evidence have shown the importance of this segment for fibril formation. The crystal structure reveals an out-of-register Class 5 steric zipper with a wet and a dry interface. To examine the possible interaction of 5RQEFEV10 with the tau fibril core, we modeled the binding of the wet interface of the 5RQEFEV10 structure with the 313VDLSKVTSKC322 region of the Alzheimer’s Disease tau filament structures. This model is consistent with, and helps to explain previous findings on the possible interaction of these two segments, distant in sequence. In addition, we discuss the possible conservation of this interaction across multiple polymorphs of tau.
When does uncertainty avoidance promote customer-to-customer intercultural service encounters?
Authors: Ghantous Nabil , Maher Amro A. 
Published: December 2018

PurposePrevious literature has reported inconsistent findings regarding the impact of uncertainty avoidance (UA) on intercultural experiences. This includes positive, negative and insignificant associations between UA on the one hand and cosmopolitanism or comfort with intercultural service encounters (ICSE) on the other hand. The purpose of this paper is to participate in addressing these contradictions. More specifically, this study examines how UA affects expatriate cosmopolitanism as well as approach of service environments patronized by local customers by introducing two moderators: national identification and perceived discrimination.Design/methodology/approachThe authors propose a conceptual model based on the results of a literature review. The authors test it with survey data collected from Indian expatriates (n=341) living in Qatar, using structural equation modeling.FindingsThe results corroborate the moderating role of national identification. Under low identification, expatriate consumers engage in a prospective form of uncertainty management, leading them to adopt a more cosmopolitan stance. Under high identification, their uncertainty plays an inhibitory role, reducing their cosmopolitanism and negatively affecting their approach of service places patronized by local consumers. Perceived discrimination did not moderate the impact of UA as expected on either cosmopolitanism or approach.Originality/valueThis paper extends the prior research on UA by testing how two moderators could activate either a prospective or an inhibitory form of uncertainty. It also contributes to research on ICSE, by focusing on customer-to-customer interactions in a multicultural marketplace.
Impedance control of collaborative robots based on joint torque servo with active disturbance rejection
Authors: Ren Tianyu , Dong Yunfei , Wu Dan , Chen Ken 
Published: December 2018

Purpose
The purpose of this paper is to present a simple yet effective force control scheme for collaborative robots by addressing the problem of disturbance rejection in joint torque: inherent actuator flexibility and nonlinear friction.

Design/methodology/approach
In this paper, a joint torque controller with an extended state observer is used to decouple the joint actuators from the multi-rigid-body system of a constrained robot and compensate the motor friction. Moreover, to realize robot force control, the authors embed this controller into the impedance control framework.

Findings
Results have been given in simulations and experiments in which the proposed joint torque controller with an extended state observer can effectively estimate and compensate the total disturbance. The overall control framework is analytically proved to be stable, and further it is validated in experiments with a robot testbed.

Practical implications
With the proposed robot force controller, the robot is able to change its stiffness in real time and therefore take variable tasks without any accessories, such as the RCC or 6-DOF F/T sensor. In addition, programing by demonstration can be realized easily within the proposed framework, which makes the robot accessible to unprofessional users.

Originality/value
The main contribution of the presented work is the design of a model-free robot force controller with the ability to reject torque disturbances from robot-actuator coupling effect and motor friction, applicable for both constrained and unconstrained environments. Simulation and experiment results from a 7-DOF robot are given to show the effectiveness and robustness of the proposed controller.
Endogenous consumers’ preferences as drivers of green corporate social responsibility
Authors: Barboza Gustavo 
Published: December 2018

PurposeThis paper’s main objective is to expand the demand-driven strategic field by developing a model where endogenization of consumers’ preferences for clean(er) products becomes the driver of the firm green corporate social responsible (GCSR) profit maximization behavior.Design/methodology/approachThe model proposes that in undifferentiated markets, firms using a conventional technology manage production-related negative externalities via information asymmetries. In turn, when consumer socially responsible individuals (CnSR) discover the nature of the information asymmetries, they then reveal their preferences. The building block of the model is that CnSR derive value both from intrinsic as well as extrinsic product features, and derive negative satisfaction from the production negative externalities. In turn, CnSR preferences offer a higher willingness to pay for a combined intrinsic (private good and direct utility) and extrinsic (public good and feel good–do good utility) product.FindingsThe model demonstrates that the firm’s GCSR behavior is a technological-driven process directly affecting the extrinsic component of the product through the development of a safe technology, and exclusively targeting CnSR type of consumers. The corollary of the model is that for the firm pursuing a GCSR behavior, the development of a competitive advantage with higher firm performance leads to profit maximization when exclusively serving the GCSR segment of the market. Thus, GCSR is the result of unusual innovation efforts.Originality/valueThis paper presents a model that expands the field of strategic management through the demand-driven incorporation and respective modeling. To the best of the author’s knowledge, this is the first model to explicitly develop this relationship in this format.
The discrete and differential impact of monetary policy
Authors: McCredie Bronwyn 
Published: December 2018

AbstractThis study exploits a unique feature of the Australian monetary policy environment to determine whether economic recovery can be stimulated via central bank communications. This study finds that unexpected monetary policy announcements and communications have a significant and comparable impact on the value and volatility of the Australian foreign exchange market, suggesting that they can be used interchangeably to stimulate economic recovery. However, further analysis reveals that the state of the economy influences this impact. Specifically, during poor economic states, monetary policy actions speak louder than words, an adage that in this context provides actionable information for central bank regulators.
Uterotonics in elective caesarean delivery: a randomised non‐inferiority study comparing carbetocin 20 μg and 100 μg
Authors: Tabl S. , Balki M. , Downey K. , Tomlinson G. , Farine D. , Seaward G. , Carvalho J. C. A. 
Published: December 2018

SummaryPostpartum haemorrhage is the leading cause of maternal mortality worldwide and prophylactic uterotonic drug administration after the delivery of the infant is advised. Carbetocin is recommended as an uterotonic, but the minimum effective dose has not been verified. We compared the efficacy of two doses of intravenous carbetocin (20 μg and 100 μg) in women undergoing elective caesarean delivery. This was a randomised, double‐blind, non‐inferiority study in women at low risk of postpartum haemorrhage. Carbetocin was administered on delivery of the anterior shoulder of the neonate. Uterine tone was assessed by the obstetrician 2 min and 5 min after carbetocin administration according to an 11‐point numerical rating scale (0 = atonic uterus and 10 = firm uterus). The primary outcome was uterine tone 2 min after carbetocin administration. The pre‐specified non‐inferiority margin was 1 point on the 11‐point scale. Secondary outcomes included: uterine tone at 5 min; use of additional uterotonics within 24 h; blood loss; and adverse effects. Data were available for 53 women in the carbetocin‐20 group and for 55 women in the carbetocin‐100 group. The mean (SD) uterine tone at 2 min was 7.5 (1.9) in the carbetocin‐20 group and 8.0 (1.5) in the carbetocin‐100 group. The lower limit of the one‐sided 95%CI for the mean difference was outside the non‐inferiority margin (at −1.1; p = 0.11) meaning non‐inferiority of carbetocin 20 μg compared with carbetocin 100 μg could not be confirmed. However, the secondary outcome measures of uterine tone at 5 min, blood loss and use of additional uterotonics were similar in both groups.
Randomised controlled trial on the impact of kinesthetic stimulation on early somatic growth of preterm infants in Kangaroo position
Authors: Aldana Acosta Andrea Carolina , Tessier Rejean , Charpak Nathalie , Tarabulsy George 
Published: December 2018

AbstractAimEvaluation of early growth in preterm infants receiving kinesthetic stimulation with massage in Kangaroo position or in incubator.MethodsA cohort of 66 infants between 30 and 33 weeks of gestational age (GA), born at a university hospital in 2013 in Bogota, were randomised when eligible to intervention. We measured weight gain (g/kg/day) at five days and 15 days postrandomisation and weight at 40 weeks, according to chronological age at randomisation.ResultsDaily weight gain was significantly higher (p = 0.02) with kinesthetic stimulation in Kangaroo position with a growth at five days of 11.0 g/kg/day (95% CI 5.7;16.3) and at 15 days of 12.1 g/kg/day (95% CI 10.4;13.7) versus 2.1 g/kg/day (95% CI −3.1;7.4) at five days and 9.4 g/kg/day (95% CI 7.7;11.1) at 15 days in incubator. Weight at 40 weeks was higher (p = 0.05) in Kangaroo position group (2.904 g) than in incubator group (2.722 g) (95% CI 2.784;3.007). Daily weight gain according to chronological age at randomisation was higher when kinesthetic stimulation initiates before five days of life in Kangaroo position with 1.53 g/kg/day (95% CI 5.9;9.0) versus −11.9 g/kg/day (95% CI −19.0;−4.8) in incubator.ConclusionEarly kinesthetic stimulation in Kangaroo position reduces the initial weight loss in infants between 30–33 weeks born without major health problems.
Maternal psychological distress after severe pregnancy hypertension was associated with increased child behavioural problems at the age of 12
Authors: Beukers Fenny , Aarnoudse‐Moens Cornelieke S. H. , van Weissenbruch Mirjam M. , Ganzevoort Wessel , van Goudoever Johannes B. , van Wassenaer‐Leemhuis Aleid G. 
Published: December 2018

AbstractAimWe examined the association between early maternal psychological distress after severe hypertensive disorders of pregnancy (HDP) and behavioural issues in their 12‐year‐old offspring.MethodsThis secondary analyses of a prospective mother–child birth cohort focused on 95 women with severe HDP and their singleton offspring. The mothers were recruited during pregnancy from 2000 to 2003 in Amsterdam, the Netherlands. Maternal distress at child term age and three months post‐term was measured using the Symptom Checklist‐90. The Child Behaviour Checklist for six years to 18 years was used to quantify social and attention problems in their offspring at 12 years of age. Perinatal and neonatal risk factors were also analysed.ResultsThe children were born at a mean age of just under 32 weeks and 90% weighed below the 10th percentile. High psychological distress (score ≥133) affected 45% of the mothers at term age and 44% three months post‐term. Child social problems were significantly associated with maternal distress at three months and were highest in cases of high maternal distress in combination with major neonatal morbidity. Child attention problems were associated with maternal anxiety at three months post‐term.ConclusionEarly maternal psychological distress after severe maternal HDP was associated with childhood behavioural issues at the age of 12.
Land use change in the high mountain belts of the central Apennines led to marked changes of the grassland mosaic
Authors: Malatesta Luca , Tardella Federico Maria , Tavoloni Marco , Postiglione Nicola , Piermarteri Karina , Catorci Andrea 
Published: December 2018

AbstractAimsHigh mountain pastures are hotspots of biodiversity, but grazing cessation and climate change are causing tall‐grass encroachment and expansion of scrublands and forests. As part of biodiversity conservation efforts, grassland variation needs to be investigated at different spatial scales. We aimed to assess the landscape mosaic variation that occurred between 1988 and 2015 in the higher Mediterranean mountains. We investigated the recovery or land‐degradation processes related to land use change, the effects of site condition, the impacts on grassland mosaic heterogeneity, and the threats to biodiversity.LocationSibillini Mountains (central Italy), over 1,650 m a.s.l.MethodsWe used two‐step object‐based supervised classification on Landsat 5 and 8 satellite images to analyze changes in landscape patterns and vegetation cover on formerly low‐intensity pastures, by assessing the Normalized Difference Vegetation Index variation between 1988 and 2015. Twenty percent of the polygons obtained from segmentation were visually interpreted and assigned to five land cover classes. We generated a land use transition matrix and used Fourier Transforms to detect trends in variation of landscape mosaics and fragmentation.ResultsWe observed prominent dynamics of the grassland mosaic leading to the homogenization of its structure through decreasing patch heterogeneity, especially on south‐facing slopes. Grasslands shifted from open communities to dense pastures, with a reduction of scree and spread of tall grasses. The former trend could be understood as a recovery process reverting screes to conditions in equilibrium with local landform and climatic features, while the invasion of tall grasses is a land‐degradation process that might lead to local species extinction and loss of habitat connectivity.ConclusionsPronounced changes in the large‐scale landscape characteristics, mainly due to land use changes, of which scientists and managers of protected areas are not fully aware, are underway in the top mountain sectors of the study area.
Bottom‐up gamma and bipolar disorder, clinical and neuroepigenetic implications
Authors: Garcia‐Rill Edgar , D'Onofrio Stasia , Mahaffey Susan C , Bisagno Veronica , Urbano Francisco J 
Published: December 2018

ObjectivesThis limited review examines the role of the reticular activating system (RAS), especially the pedunculopontine nucleus (PPN), one site of origin of bottom‐up gamma, in the symptoms of bipolar disorder (BD).MethodsThe expression of neuronal calcium sensor protein 1 (NCS‐1) in the brains of BD patients is increased. It has recently been found that all PPN neurons manifest intrinsic membrane beta/gamma frequency oscillations mediated by high threshold calcium channels, suggesting that it is one source of bottom‐up gamma. This review specifically addresses the involvement of these channels in the manifestation of BD.ResultsExcess NCS‐1 was found to dampen gamma band oscillations in PPN neurons. Lithium, a first line treatment for BD, was found to decrease the effects of NCS‐1 on gamma band oscillations in PPN neurons. Moreover, gamma band oscillations appear to epigenetically modulate gene transcription in PPN neurons, providing a new direction for research in BD.ConclusionsThis is an area needing much additional research, especially since the dysregulation of calcium channels may help explain many of the disorders of arousal in, elicit unwanted neuroepigenetic modulation in, and point to novel therapeutic avenues for, BD.
Aberrant accrual of BIN1 near Alzheimer’s disease amyloid deposits in transgenic models
Authors: De Rossi Pierre , Andrew Robert J. , Musial Timothy F. , Buggia‐Prevot Virginie , Xu Guilian , Ponnusamy Moorthi , Ly Han , Krause Sofia V. , Rice Richard C. , de l’Estoile Valentine , Valin Tess , Salem Someya , Despa Florin , Borchelt David R. , Bindokas Vytas P. , Nicholson Daniel A. , Thinakaran Gopal 
Published: December 2018

AbstractBridging integrator 1 (BIN1) is the most significant late‐onset Alzheimer’s disease (AD) susceptibility locus identified via genome‐wide association studies. BIN1 is an adaptor protein that regulates membrane dynamics in the context of endocytosis and membrane remodeling. An increase in BIN1 expression and changes in the relative levels of alternatively spliced BIN1 isoforms have been reported in the brains of patients with AD. BIN1 can bind to Tau, and an increase in BIN1 expression correlates with Tau pathology. In contrast, the loss of BIN1 expression in cultured cells elevates Aβ production and Tau propagation by insfluencing endocytosis and recycling. Here, we show that BIN1 accumulates adjacent to amyloid deposits in vivo. We found an increase in insoluble BIN1 and a striking accrual of BIN1 within and near amyloid deposits in the brains of multiple transgenic models of AD. The peri‐deposit aberrant BIN1 localization was conspicuously different from the accumulation of APP and BACE1 within dystrophic neurites. Although BIN1 is highly expressed in mature oligodendrocytes, BIN1 association with amyloid deposits occurred in the absence of the accretion of other oligodendrocyte or myelin proteins. Finally, super‐resolution microscopy and immunogold electron microscopy analyses highlight the presence of BIN1 in proximity to amyloid fibrils at the edges of amyloid deposits. These results reveal the aberrant accumulation of BIN1 is a feature associated with AD amyloid pathology. Our findings suggest a potential role for BIN1 in extracellular Aβ deposition in vivo that is distinct from its well‐characterized function as an adaptor protein in endocytosis and membrane remodeling.
French validation of the FACE‐Q Rhinoplasty module
Authors: Radulesco Thomas , Penicaud Martin , Santini Laure , Graziani Jade , Dessi Patrick , Michel Justin 
Published: December 2018

ObjectivesThe aim of this study was to translate the FACE‐Q "Rhinoplasty" module into French and validate its use for the French‐speaking population.Design"Satisfaction with the nose" and "Satisfaction with nostrils" questionnaires were used and translated.SettingsWe were granted permission to use the FACE‐Q rhinoplasty module by the development team. These two questionnaires constitute the rhinoplasty module of the FACE‐Q questionnaire. ISPOR and WHO recommendations were used to complete the translation process from English into French in six steps.Main outcome measurementOur goal was to obtain, not a literal translation, but rather a translation of the idea or concept.ResultsEach step allowed us to make changes to achieve a conceptual translation equivalent to the original version.ConclusionThe FACE‐Q questionnaire is a reference in the field of cosmetic surgery outcome evaluation. The use of two validated translation recommendations, with a six‐step translation‐back translation process, leads to a French version corresponding to the original. This version is usable in a French‐speaking population.
Infant gaze following depends on communicative signals: An eye‐tracking study of 5‐ to 7‐month‐olds in Vanuatu
Authors: Hernik Mikołaj , Broesch Tanya 
Published: December 2018

AbstractGaze is considered a crucial component of early communication between an infant and her caregiver. When communicatively addressed, infants respond aptly to others’ gaze by following its direction. However, experience with face‐to‐face contact varies across cultures, begging the question whether infants’ competencies in receiving others’ communicative gaze signals are universal or culturally specific . We used eye‐tracking to assess gaze‐following responses of 5‐ to 7‐month olds in Vanuatu, where face‐to‐face parent–infant interactions are less prevalent than in Western populations. We found that—just like Western 6‐month‐olds studied previously—5‐ to ‐7‐month‐olds living in Vanuatu followed gaze only, when communicatively addressed. That is, if presented gaze shifts were preceded by infant‐directed speech, but not if they were preceded by adult‐directed speech. These results are consistent with the notion that early infant gaze following is tied to infants’ early emerging communicative competencies and rooted in universal mechanisms rather than being dependent on cultural specificities of early socialization.
Prediction in infants and adults: A pupillometry study
Authors: Zhang Felicia , Jaffe‐Dax Sagi , Wilson Robert C. , Emberson Lauren L. 
Published: December 2018

AbstractAdults use both bottom‐up sensory inputs and top‐down signals to generate predictions about future sensory inputs. Infants have also been shown to make predictions with simple stimuli and recent work has suggested top‐down processing is available early in infancy. However, it is unknown whether this indicates that top‐down prediction is an ability that is continuous across the lifespan or whether an infant's ability to predict is different from an adult's, qualitatively or quantitatively. We employed pupillometry to provide a direct comparison of prediction abilities across these disparate age groups. Pupil dilation response (PDR) was measured in 6‐month olds and adults as they completed an identical implicit learning task designed to help learn associations between sounds and pictures. We found significantly larger PDR for visual omission trials (i.e. trials that violated participants’ predictions without the presentation of new stimuli to control for bottom‐up signals) compared to visual present trials (i.e. trials that confirmed participants’ predictions) in both age groups. Furthermore, a computational learning model that is closely linked to prediction error (Rescorla‐Wagner model) demonstrated similar learning trajectories suggesting a continuity of predictive capacity and learning across the two age groups.
Tei index is associated with survival in cirrhosis patients treated with transjugular intrahepatic portosystemic shunt
Authors: Song Yan , Li Weizhi , Xue Hui , Ruan Litao 
Published: December 2018

BackgroundTransjugular intrahepatic portosystemic shunt (TIPS) is the method of choice for the treatment of portal hypertension. The Tei index is the most sensitive indicator of myocardial function.DesignThis study enrolled 31 patients with cirrhosis who underwent TIPS and were followed up over a median period of 34 months (range 2–60 months). Baseline Meld score and the changes in the Tei index within 1 month after TIPS and their potential relationship with prognosis were evaluated. The primary endpoint was mortality.ResultsThirteen patients (42%) died during follow‐up. Survival analysis showed that the pre‐TIPS Tei index (RR = −7.660, 95% confidence interval 0.000–0.069, P < 0.05) and the baseline MELD score > 10 (RR = 0.305,95% CI:1.036–1.778, P < 0.05) were significantly associated with survival rate after TIPS.ConclusionThe Tei index before TIPS is associated with the survival of patients with cirrhosis after TIPS, and is potentially a predictive factor of mortality.