bluuebunny/crossref_metadata_2025_split huggingface dataset:
On the molecular origin of the sensitivity to impact of cyclic nitramines
Authors: Oliveira Marco A. S. , Borges Itamar 
Published: December 2018

AbstractNitramine explosives can combine relative insensitivity to initiation and great energy content. In this work, based on a previous approach developed for nitroaromatic explosives, we propose four mathematical models to correlate impact sensitivity, given by the h50 value, to molecular charge properties. Fourteen cyclic nitramines were studied using Density Functional Theory (DFT). Six molecules of the set have measured h50 values, which were used to evaluate the sensitivity models. Converged DFT charge densities of the molecules were partitioned and analyzed according to the distributed multipole analysis (DMA) atom‐centered method. The sensitivity models were based on the DMA electric multipole values. The electron withdrawing role of the nitro group and the strong polarization of the charges of the nitrogen atom in the amine group were clearly identified. The influence of the electronic properties on the sensitivity of the explosives was characterized by including in the sensitivity models the charge values of the nitro or the nitramine groups and electron delocalization, the latter quantified by the DMA quadrupole values of the ring atoms. Inclusion of electron delocalization effects can improve the prediction of h50 values for two out of the five strained‐ring nitramines in the set. The charge values of the nitramine groups are the most important molecular property affecting the impact sensitivity. The h50 values of eight nitramine explosives of the set not available experimentally were computed.
On the shell‐confined atom problem
Authors: Pupyshev Vladimir I. , Montgomery Henry E. 
Published: December 2018

AbstractThe properties of spherically symmetric, one‐electron atomic systems are analyzed for the systems where the electron is placed in the region between two impenetrable concentric spheres of radii Rint and Rext. The changes in the structure of the energy levels of low‐lying electron states and the corresponding variations in radial wave functions are analyzed for different types of changes in Rint and Rext. Special attention is paid to the changes in electric dipole polarizability for problems with varied dimension, D, of the space. The form and the quality of some simple classical estimates for polarizability are also studied for various space dimensions.
Al‐Robotics team: A cooperative multi‐unmanned aerial vehicle approach for the Mohamed Bin Zayed International Robotic Challenge
Authors: Castaño Ángel R. , Real Fran , Ramón‐Soria Pablo , Capitán Jesús , Vega Víctor , Arrue Begoña C. , Torres‐González Arturo , Ollero Aníbal 
Published: December 2018

AbstractThe Al‐Robotics team was selected as one of the 25 finalist teams out of 143 applications received to participate in the first edition of the Mohamed Bin Zayed International Robotic Challenge (MBZIRC), held in 2017. In particular, one of the competition Challenges offered us the opportunity to develop a cooperative approach with multiple unmanned aerial vehicles (UAVs) searching, picking up, and dropping static and moving objects. This paper presents the approach that our team Al‐Robotics followed to address that Challenge 3 of the MBZIRC. First, we overview the overall architecture of the system, with the different modules involved. Second, we describe the procedure that we followed to design the aerial platforms, as well as all their onboard components. Then, we explain the techniques that we used to develop the software functionalities of the system. Finally, we discuss our experimental results and the lessons that we learned before and during the competition. The cooperative approach was validated with fully autonomous missions in experiments previous to the actual competition. We also analyze the results that we obtained during the competition trials.
Preservice Teacher Knowledge, Print Exposure, and Planning for Instruction
Authors: Kozak Stephanie , Martin‐Chang Sandra 
Published: December 2018

AbstractTeachers who are knowledgeable about the basic structure of the English language incorporate this knowledge into their instruction. In this study, the authors explored a similar relation between knowledge of print exposure and planning for a grade 5 classroom. The personal reading experience (print exposure) of 106 preservice teachers was measured for three genres: storybooks, children's and young adult literature, and adult fiction. Teacher knowledge was measured by two tasks: defining terms and evaluating instructional practices. Planning for instruction was measured by asking participants to plan for a week of grade 5 language arts instruction. Correlational analyses revealed that print exposure, teacher knowledge, and time allocated for student reading in a grade 5 classroom were positively related. Furthermore, regression analyses revealed that familiarity with authors of children's and young adult literature accounted for significant variance on both knowledge tasks even after controlling for other forms of print exposure (storybooks and adult fiction). The data suggest that knowledge about print exposure and personal reading experience, especially of children's and young adult literature, are both associated with planning for instruction in the upper elementary grades. The results are discussed in relation to teacher training.
Misaccounting for endogeneity: The peril of relying on the Heckman two‐step method without a valid instrument
Authors: Wolfolds Sarah E. , Siegel Jordan 
Published: December 2018

Research SummaryStrategy research addresses endogeneity by incorporating econometric techniques, including Heckman's two‐step method. The economics literature theorizes regarding optimal usage of Heckman's method, emphasizing the valid exclusion condition necessary in the first stage. However, our meta‐analysis reveals that only 54 of 165 relevant papers published in the top strategy and organizational theory journals during 1995–2016 claim a valid exclusion restriction. Without this condition being met, our simulation shows that results using the Heckman method are often less reliable than OLS results. Even where Heckman is not possible, we recommend that other rigorous identification approaches be used. We illustrate our recommendation to use a triangulation of identification approaches by revisiting the classic global strategy question of the performance implications of cross‐border market entry through greenfield or acquisition.Managerial SummaryManagers make strategic decisions by choosing the best option given the particular circumstances of their firm. However, researchers had previously not taken into consideration these circumstances when evaluating the outcome of that choice. The Heckman method importantly addresses this situation, but requires that the researcher have some variable that effects the best option for the firm, but not the outcome. We show that researchers frequently do not utilize such a variable, and demonstrate that the Heckman method can exacerbate estimation issues in this case. We then provide an approach that researchers can use to address the challenge of determining the outcome of a strategic decision, and illustrate it with an empirical examination of the performance implications of cross‐border market entry through greenfield or acquisition.
Modulatory effect of Turnera diffusa against testicular toxicity induced by fenitrothion and/or hexavalent chromium in rats
Authors: El‐Demerdash Fatma M. , Jebur Ali B. , Nasr Hoda M. , Hamid Hanin M. 
Published: December 2018

AbstractOxidative stress and increased production of reactive oxygen species have been implicated in pesticides and heavy metals toxicity. The objective of this study was to investigate the efficacy of Turnera diffusa Willd (damiana) on counteracting fenitrothion (FNT) and/or potassium dichromate (CrVI)‐induced testicular toxicity and oxidative injury in rats. FNT and/or CrVI intoxicated animals revealed a significant increase in thiobarbituric acid reactive substances and hydrogen peroxide levels. While, reduced glutathione and protein content, as well as antioxidant enzymes, phosphatases, and aminotransferases activities, were significantly decreased. In addition, significant changes in testosterone and follicle‐stimulating hormone levels were detected. Furthermore, histological and immunohistochemical alterations were observed in rat testes and this supported the observed biochemical changes. On the other hand, rats treated with damiana alone decreased lipid peroxidation and increased most of the examined parameters. Moreover, damiana pretreatment to FNT and/or CrVI‐intoxicated rats showed significant improvement in lipid peroxidation, enzyme activities, and hormones as compared with their respective treated groups. Conclusively, rats treated with both FNT and/or CrVI showed pronounced hazardous effect especially in their combination group in addition, Turnera diffusa had a potential protective role against FNT and/or CrVI induced testicular toxicity.
The sonic hedgehog signaling pathway is suppressed following PCB1254exposure during retinal development
Authors: Wei Ning , Zhang Xin , Hong Qin , Jiang Yue , Zhang Qingyu , Guo Xirong , Chi Xia , Tong Meiling , Liu Qinghuai 
Published: December 2018

AbstractPolychlorinated biphenyl (PCB) has been reported to have detrimental effects on retinal development. In order to explore the role of Shh signaling in retinal development after PCB1254exposure in vivo and in vitro, zebrafish and RGC‐5 retinal cell line were used. Compared with the controls, PCB exposure inhibited proliferation and increased the apoptosis levels. The expression of Shh mRNA decreased in the PCB1254‐treated groups both in vivo and in vitro compared with that of the controls. Theptch2mRNA expression increased in the experimental groups. The expression ofgli2mRNA decreased in the PCB1254‐treated groups. Immunofluorescence and western blotting assays confirmed that the expression of Shh proteins decreased in PCB1254‐treated groups compared with control groups. Moreover, ptch2 protein levels increased in the PCB1254‐treated groups as well as the decreased protein expressions of gli1 and gli2. These results demonstrated that Shh signaling pathway may participate in the damage of retinal development caused by PCB1254exposure, providing evidence that eye diseases could be caused by environmental pollutants.
Potential anti‐inflammatory and antioxidant effects of Citrus aurantium essential oil against carbon tetrachloride‐mediated hepatotoxicity: A biochemical, molecular and histopathological changes in adult rats
Authors: Ben Hsouna Anis , Gargouri Manel , Dhifi Wissal , Ben Saad Rania , Sayahi Naima , Mnif Wissem , Saibi Walid 
Published: December 2018

AbstractThe present study aimed (1) to investigate the chemical composition as well as the anti‐inflammatory properties and in vitro antioxidant activity of Citrus aurantium peel essential oil (pEOCa) and (2) to evaluate its potential effect in vivo. The main results showed that the major components of pEOCa are Limonene and Linalool. Additionally, DPPH scavenging ability and β‐carotene bleaching inhibition tests confirmed the antioxidant capacity of pEOCa. Our oil reduced the production of NO by LPS‐stimulated RAW264,7 macrophages in a concentration‐dependent. This inhibition occurred at a transcriptional level. pEOCa in CCl4 treated rats alleviated hepatotoxicity as monitored by the improvement of hepatic oxidative stress biomarkers levels plasma biochemical parameters, and DNA molecule aspect. Furthermore, the mRNA gene expression of Cu‐Zn SOD, CAT, and GPx increased under CCl4+ pEOCa exposure to reach the same value to the control. Similarly, antioxidant activities of these three enzymes changed in accordance with the mRNA levels. These results were confirmed by the histological results. It seems obvious that the treatment with pEOCa prevented liver damage induced by CCl4, thus preventing the harmful effects of free radicals.
Long-term clinical and functional course of borderline personality disorder: A meta-analysis of prospective studies
Authors: Álvarez-Tomás Irene , Ruiz José , Guilera Georgina , Bados Arturo 
Published: December 2018

AbstractBackground:This meta-analytic review is the first to synthesise findings from prospective research on the long-term course of borderline personality disorder in adult clinical populations.Methods:Systematic searches were conducted in Medline, PsycINFO, PsycArticles, PubMed and Scopus within the period 1990-2017. Inclusion criteria were: (1) adult BPD sample diagnosed by a validated, semi-structured interview; (2) at least two prospective assessments of outcomes; and (3) follow-up period ≥ 5 years. Quality of evidence was rated with the Systematic Assessment of Quality in Observational Research (SAQOR). Four outcomes were meta-analysed using mixed-effect methods: remission from BPD diagnosis, completed suicide, depressive symptoms, and functioning. Potential moderators regarding the natural course and the initial treatment received were studied.Results:Eleven studies met the inclusion criteria, with 837 participants from nine countries being followed. Between 50% and 70% of the BPD patients achieved remission in the long-term. Significant reductions in depression and functional impairment were also found. Mean suicide rate ranged from 2% to 5%. Younger age was associated with higher likelihood for remission. Being female was correlated with lower functional improvement. Despite some positive trends, there were no significant associations between treatment moderators and the long-term outcome.Conclusions:Findings suggest that the course of BPD is characterised by symptomatic amelioration and a slight functional improvement in the long-term. Age and gender modulate the long-term prognosis and should be considered to adapt treatment resources. Further research is required to draw robust conclusions on the long-term effects of psychotherapeutic interventions.
RGAAT: A Reference-Based Genome Assembly and Annotation Tool for New Genomes and Upgrade of Known Genomes
Authors: Liu Wanfei , Wu Shuangyang , Lin Qiang , Gao Shenghan , Ding Feng , Zhang Xiaowei , Aljohi Hasan Awad , Yu Jun , Hu Songnian 
Published: December 2018

Abstract
The rapid development of high-throughput sequencing technologies has led to a dramatic decrease in the money and time required for de novo genome sequencing or genome resequencing projects, with new genome sequences constantly released every week. Among such projects, the plethora of updated genome assemblies induces the requirement of version-dependent annotation files and other compatible public dataset for downstream analysis. To handle these tasks in an efficient manner, we developed the reference-based genome assembly and annotation tool (RGAAT), a flexible toolkit for resequencing-based consensus building and annotation update. RGAAT can detect sequence variants with comparable precision, specificity, and sensitivity to GATK and with higher precision and specificity than Freebayes and SAMtools on four DNA-seq datasets tested in this study. RGAAT can also identify sequence variants based on cross-cultivar or cross-version genomic alignments. Unlike GATK and SAMtools/BCFtools, RGAAT builds the consensus sequence by taking into account the true allele frequency. Finally, RGAAT generates a coordinate conversion file between the reference and query genomes using sequence variants and supports annotation file transfer. Compared to the rapid annotation transfer tool (RATT), RGAAT displays better performance characteristics for annotation transfer between different genome assemblies, strains, and species. In addition, RGAAT can be used for genome modification, genome comparison, and coordinate conversion. RGAAT is available at https://sourceforge.net/projects/rgaat/ and https://github.com/wushyer/RGAAT_v2 at no cost.
A rare case of metaplastic carcinoma of the breast that could be diagnosed with preoperative core needle biopsy and the improbability of skin invasion
Authors: Takahashi Keiichi 
Published: December 2018

ABSTRACT

Background:
Metaplastic carcinoma of the breast (MCB) is a rare type of breast cancer that accounts for 1% of all cases of invasive breast cancer. This MCB is categorized into special types of breast cancers.
MCB is characterized by the presence of multiple components and transitional cells between two tissue types, because the tumor cells differentiate in different directions and degrees into a variety of cells other than glandular cells. However, MCB is often misdiagnosed preoperatively as ordinary breast cancer based on several tissue imaging findings. The diagnosis of MCB is highly difficult with cytology and even with core needle biopsy (CNB). The diagnostic rate of MCB with CNB is as low as 40%, with the remaining 60% diagnosed as ordinary mammary duct carcinoma.
MCB is unlikely to respond to anticancer drugs, surgery as the initial treatment is prioritized over preoperative anticancer drug therapy. Therefore, accurate preoperative diagnosis is important.
To date, no report has described the likelihood of skin invasion in a patient with MCB.

Case presentation:
This case report describes a 67-year-old woman with an unremarkable past or family history, who visited the author's clinic after noticing a swelling of her right nipple and a lump located around her right nipple 2 months previously. CNB was performed.

Results:
The pathological findings of the CNB specimen indicated metaplastic carcinoma. Metaplastic carcinoma with sarcomatoid changes, i.e., spindle cell carcinoma or matrix-producing carcinoma, was suspected. There was no skin invasion despite the presence of both a large mass and large swelling of the nipple in this patient.

Conclusions:
For MCB, preoperative anticancer drug therapy could be avoided and surgery may be considered the initial treatment.
Despite the presence of a large mass, MCB may be less likely to cause skin invasion than ordinary breast cancer of the same size.

Highlights:
Mucocele of the vermiform appendix: diagnostic challenges and therapeutic approach
Authors: Cunha Carlos Magno Queiroz da , Lima Douglas Marques Ferreira de , Neto Giovanni Troiani , Lima Francisco Fernando Pimenta , Pimenta Caio Regis de Oliveira Medeiros , Gomes José Walter Feitosa 
Published: December 2018

Abstract
Introduction Mucocele of the appendix is defined as the obstructive dilatation of the vermiform appendix by the abnormal accumulation of mucinous substance in its lumen. Imaging tests may be useful, but they commonly fail to evidence the etiology in question. Regarding the therapeutic approach, there are different options for treatment. Appendectomy was routinely used in simple cystadenomas, with good results. However, in cases of neoplasias, more aggressive resection is necessary, and the therapeutic course of choice is the right hemicolectomy.
Case report Patient presented to the surgery outpatient clinic with magnetic resonance imaging presenting an adnexal cyst of about 11.0 × 4.5 cm on the right. The patient had pain in the right iliac fossa for 6 months. Due to the radiological finding and persistence of the clinical picture, videolaparoscopy was performed, and an appendicular mass suggestive of mucocele was identified. A laparoscopic appendectomy was performed, with no signs of mucus extravasation. Histopathological analysis confirmed the diagnosis.
Discussion Mucocele is rarely diagnosed effectively in the preoperatively. In this context, imaging tests do rarely evidence such etiology. Given the importance of preoperative diagnosis for the definition of conduct, it is essential that this condition be always taken into account as a diagnostic hypothesis.
ERGODYNAMICS AND A SEMIOTICS OF INSTRUMENTAL COMPOSITION
Authors: Magnusson Thor 
Published: December 2018

AbstractThis article examines the techno-philosophical aspects of how we create and understand musical systems in twenty-first century computational media. Arguing that processor-based media have exploded the compositional language of new music, the article proposes a set of concepts that might help us navigate this new space of instrumental possibilities. The term ‘ergodynamics’ – and related concepts – is proposed as a useful concept when describing the phenomenological, historical and aesthetic aspects of musical instruments, as well as a lens for looking at new compositional practices that can be defined as being either ‘idiomatic’ or ‘supra-instrumental’. The article explores the difference in composing for acoustic, electronic and digital instruments, and suggests that new musical practice can be characterised by a move from composing work to inventing systems.
TO HAVE AND TO HOLD: TOUCH AND THE VINYL RESURGENCE
Authors: Harper Adam 
Published: December 2018

AbstractThis article reviews a recent wave of literature on the resurgence of vinyl records, examining what it has claimed about vinyl's capacity for tangibility and the contrast to digital media, associated with intangibility. These claims are explained with reference to other literatures on touch, and it is suggested that vinyl's haptics mediates and embodies the emotionally rewarding production of a sense of self. The apparent contrast of vinyl aesthetics with classical music aesthetics is also discussed, and the presence of contemporary classical music within the vinyl resurgence is considered.
THE TOUCH OF THE STETHOSCOPE: SHAPING CONTEXT IN INTIMATE PERFORMANCE
Authors: Naccarato Teoma , MacCallum John 
Published: December 2018

AbstractWhen tools like the stethoscope and electrocardiogram are appropriated for use beyond their intended purpose – for example in music and dance performance – how does the training of foreign users shift the framing of sound, and therefore what types of sounds from the body and apparatus come to be analysed or considered? Can we qualify the difference between a doctor and a composer listening to the heart through a stethoscope? How do the motives and methods of practitioners inform what they hear, and how they touch – to the exclusion of sensory processes beyond their frame of reference? As a choreographer and composer working with heart rate sensors, we do not seek to reveal or represent the invisible workings of the heart. Rather, in our performances and installations, the sonification and haptification of heart rhythms – along with the noise produced by the apparatus and its use – are a means to compose a context for intimate listening and touch between performers and visitors at the edges of appropriateness.
POETRY'S PLAYGROUND: TRANSFORMING THE WRITTEN WORD INTO AN INTEGRAL SENSORY EXPERIENCE
Authors: Priestley Amber 
Published: December 2018

AbstractFor the Touch Symposium in September 2017, I presented my installation,World to escape to, salty seas to float, based on a poem by Sarah Kelly. I took as the starting point a hidden space behind the words, which through feeling, I converted into a structure combining words and sound, where the audience could create their own work through touching and interfering with items inspired by the sensations the poem gave me.