bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cross-Cumulation Arrangement as FTA Under GATT Article XXIV
Authors: Kim Jong Bum 
Published: August 2019

ABSTRACT
A cross-cumulation arrangement helps manufacturers meet the demands of the global value chain economy by facilitating the sourcing of intermediate products within the territories of participants in the arrangement. It is a de facto free-trade area formed by a network of bilateral free-trade areas underpinning the arrangement. However, a cross-cumulation clause provided in a bilateral free-trade area that underpins a cross-cumulation arrangement is inconsistent with General Agreement on Tariffs and Trade (GATT) Articles I and III because the intermediate products from the participants in the arrangement are more favorably treated than products from non-participants in the arrangement. The GATT inconsistencies of a cross-cumulation clause cannot be justified by the GATT Article XXIV exception, because a cross-cumulation clause of a bilateral free-trade area derogates from the free-trade area’s aim by facilitating trade in intermediate products between the free-trade area parties and non-parties to the free-trade area that are participants in the arrangement. In contrast, a cumulation clause provided in a free-trade area contributes to the free-trade area’s aim by facilitating trade in intermediate products between the parties to the free-trade area. To bring a cross-cumulation arrangement such as the Regional Convention on Pan-Euro-Med Preferential Rules of Origin into conformity with World Trade Organization law, the arrangement and its underlying free-trade areas should be recognized as a de jure free-trade area under GATT Article XXIV and notified to the World Trade Organization as such. A large cross-cumulation arrangement as a mega-free-trade area is likely to contribute to the world trading system by harmonizing divergent free-trade area rules of origin and providing an efficient mechanism for the formation of a mega-free-trade area.
Gastric necrosis late after a Collis-Nissen procedure
Authors: Misheva Bojana , Hajjar Roy , Schwenter Frank , Martin Jocelyne , Sebajang Herawaty 
Published: August 2019

AbstractA Nissen procedure is an efficient surgical approach to treat gastroesophageal reflux disease. It is sometimes combined with a Collis gastroplasty to lengthen the functional distal esophagus to allow a 360° Nissen fundoplication without tension. We present the case of a 76-year-old female patient, with a history of a Collis-Nissen procedure, who developed extensive gastric necrosis after ingesting a significant quantity of maize. She underwent an urgent total gastrectomy with Roux-en-Y esophagojejunostomy. The cause of ischemia and necrosis in this case is believed to be an insufficient blood supply due to excessive intraluminal pressure. Necrosis of the gastric cavity is usually more likely to be due to venous insufficiency as veins’ walls are less resistant to compression than arterial vessels. Gastric necrosis after a Collis-Nissen procedure is exceedingly rare, and symptoms of such a complication are usually vague and not pathognomonic, which might delay surgical care and increase morbidity.
Temporal and angular variations of 3D core-collapse supernova emissions and their physical correlations
Authors: Vartanyan David , Burrows Adam , Radice David 
Published: August 2019

Abstract
We provide the time series and angular distributions of the neutrino and gravitational wave emissions of 11 state-of-the-art 3D non-rotating core-collapse supernova models and explore correlations between these signatures and the real-time dynamics of the shock and the proto-neutron star (PNS) core. The neutrino emissions are roughly isotropic on average, with instantaneous excursions about the mean inferred luminosity of as much as ±20 per cent. The deviation from isotropy is least for the ‘νμ’-type neutrinos and the lowest mass progenitors. Instantaneous temporal luminosity variations along a given direction for exploding models average ∼2–4 per cent, but can be as high as ∼10 per cent. For non-exploding models, they can achieve ∼25 per cent. The temporal variations in the neutrino emissions correlate with the temporal and angular variations in the mass accretion rate. We witness the lepton-number emission self-sustained asymmetry (LESA) phenomenon in all our models and find that the vector direction of the LESA dipole and that of the inner Ye distribution are highly correlated. For our entire set of 3D models, we find strong connections between the cumulative neutrino energy losses, the radius of the proto-neutron star, and the f-mode frequency of the gravitational wave emissions. When physically normalized, the progenitor-to-progenitor variation in any of these quantities is no more than ∼10 per cent. Moreover, the reduced f-mode frequency is independent of time after bounce to better than ∼10 per cent. Therefore, simultaneous measurement of gravitational waves and neutrinos from a given supernova event can be used synergistically to extract real physical quantities of the supernova core.
A stellar relic filament in the Orion star-forming region
Authors: Jerabkova Tereza , Boffin Henri M J , Beccari Giacomo , Anderson Richard I 
Published: August 2019

ABSTRACT
We report the discovery of the oldest stellar substructure in the Orion star-forming region (OSFR), the Orion relic filament. The relic filament is physically associated with the OSFR, as demonstrated by Gaia DR2 photometry and astrometry, as well as by targeted radial velocity follow-up observations of a bright subsample of proper motion-selected candidate members. Gaia DR2 parallaxes place the Orion relic filament in the more distant part of the OSFR, ∼430 pc from the Sun. Given its age, velocity dispersion, spatial extent, and shape, it is not possible for the Orion relic filament to have formed as a single stellar cluster, even taking into account residual gas expulsion. The relic filament is also too young to be a tidal stream, because Galactic tides act on much longer time-scales, of the order of 100 Myr. It therefore appears likely that the structure formed from a molecular cloud filament similar to Orion A in the OSFR and retained its morphology despite decoupling from its natal gas. Hence, the Orion relic filament bears witness to the short-lived evolutionary phase between gas removal and dispersion owing to shears and tides, and provides crucial new insights into how stars are formed in molecular clouds.
Sensory Evaluation of E-Liquid Flavors by Smelling and Vaping Yields Similar Results
Authors: Krüsemann Erna J Z , Wenng Franziska M , Pennings Jeroen L A , de Graaf Kees , Talhout Reinskje , Boesveldt Sanne 
Published: August 2019

Abstract

Introduction
Sensory research on e-liquid flavors can be performed by means of smelling and vaping. However, data comparing smelling versus vaping e-liquid flavors are lacking. This study aims to investigate if smelling could be an alternative to vaping experiments by determining the correlation for hedonic flavor assessment between orthonasal smelling and vaping of e-liquids, for smokers and nonsmokers.

Methods
Twenty-four young adult smokers (mean age 24.8 ± 9.3) and 24 nonsmokers (mean age 24.9 ± 7.7) smelled and vaped 25 e-liquids in various flavors. Participants rated liking, intensity, familiarity, and irritation on a 100-mm Visual Analog Scale. Pearson correlations within and between smelling and vaping were calculated. Differences between user groups were calculated using t tests.

Results
Correlation coefficients between smelling and vaping based on mean group ratings were 0.84 for liking, 0.82 for intensity, 0.84 for familiarity, and 0.73 for irritation. Means of the within-subjects correlation coefficients were, respectively, 0.51, 0.37, 0.47, and 0.25. Correlations between smelling and vaping varied across individuals (ranging from −0.27 to 0.87) and flavors (−0.33 to 0.81). Correlations and mean liking ratings did not differ between smokers and nonsmokers.

Conclusions
The strong group-level correlations between orthonasal smelling and vaping e-liquid flavors justify the use of smelling instead of vaping in future research. For example, smelling could be used to investigate differences in e-liquid flavor liking between (potential) user groups such as nicotine-naïve adolescents. The more modest within-subject correlations and variation across individuals and flavors merit caution in using smelling instead of vaping in other types of experiments.

Implications
This study supports the use of orthonasal smelling (instead of vaping) e-liquids to measure hedonic flavor perception in some studies where vaping would be inappropriate or not feasible. Examples of research situations where smelling e-liquids may be sufficient are (1) investigating nicotine-naïve individuals (ie, nonusers), (2) investigating individuals under legal age for e-cigarette use (ie, youth and adolescents), (3) investigating brain responses to exposure of e-liquid flavors using functional magnetic resonance imaging or electroencephalogram, and (4) comparing hedonic flavor assessment between adolescent nonusers and current smokers to provide support for future regulations on e-liquid flavors.
Patients with inflammatory rheumatic diseases: quality of self-reported medical information in a prospective cohort event monitoring system
Authors: Kosse Leanne J , Jessurun Naomi T , Hebing Renske C F , Huiskes Victor J B , Spijkers Karin M , van den Bemt Bart J F , Nurmohamed Mike T 
Published: August 2019

Abstract

Objectives
Assessment of the quality of patient-reported medical information in the Dutch Biologic Monitor and evaluation of the representativeness of the sampled participants.

Methods
Consecutive adult patients using a biologic DMARD (bDMARD) for an immune-mediated inflammatory disease were included in eight Dutch centres. For this substudy, data of 550 patients with inflammatory rheumatic diseases were used. Patient-reported bDMARD prescription, indication and combination therapy were verified for patients that permitted access to their electronic health record using percentage agreement and/or Cohen’s kappa (n = 483). Conservative post hoc sensitivity analysis was performed to account for missing data. Population representativeness was tested for the entire substudy population by comparing age, gender and prescribed bDMARD to the centres’ reference populations using Mann–Whitney U-test, χ2 goodness-of-fit or Fisher’s exact test with Monte Carlo simulation (n = 550).

Results
The correct bDMARD was reported by 95.8% of the participants. Agreement between patients and electronic health record was almost perfect for indications (κ = 0.832) and substantial for combination therapies (κ = 0.725). Agreement on combination therapies remained substantial after post hoc sensitivity analysis (κ = 0.640). Gender distribution (P &gt; 0.05) and bDMARD use (P &gt; 0.05) were similar to the reference populations. Median age was different (58.0 vs 56.0 years, P = 0.04), but considered clinically irrelevant.

Conclusion
The Dutch Biologic Monitor seems to be a valid tool to obtain patient-reported medical information. Reported medical information generally corresponded to the electronic health records and the participants represented their reference populations regarding age, gender and prescribed bDMARD.
Effects of perimenopausal transdermal estradiol on self-reported sleep, independent of its effect on vasomotor symptom bother and depressive symptoms
Authors: Geiger Paul J. , Eisenlohr-Moul Tory , Gordon Jennifer L. , Rubinow David R. , Girdler Susan S. 
Published: August 2019

Abstract

Objective:
The aim of this study was to determine the efficacy of transdermal estradiol (E2) plus intermittent progesterone (EPT) for improving self-reported sleep in perimenopausal women, after controlling for vasomotor symptoms (VMS) bother and depressive symptoms.

Methods:
Using a double-blind, placebo-controlled design, 172 healthy women meeting STRAW+10 criteria for being in the menopausal transition or early postmenopause were randomized to 12 months of transdermal E2 (0.1 mg/d) + 200 mg progesterone (12 d every 3 mo) or placebo. Using standard questionnaires, self-reported sleep, depression, and VMS bother were obtained at baseline and bimonthly postrandomization.

Results:
Controlling for baseline levels, EPT (vs placebo) led to reductions in minutes to fall asleep (estimate = −0.12, P = 0.002) and number of awakenings (estimate = −0.24, P = 0.04) over the 12 months. Controlling for changes in VMS bother and depressive symptoms, EPT still predicted reductions in minutes to fall asleep (estimate = −0.28, P = 0.02) and number of awakenings (estimate = −0.11, P = 0.02) over the 12 months.

Conclusions:
We extend existing research by demonstrating that hormone therapy (HT) in subjective sleep cannot be fully explained by improvements in VMS bother or depressive symptoms. Research to examine the mechanism (s) underlying HT's effects on sleep would have public health significance for perimenopausal women and also advance our general understanding of the pathophysiology of impaired sleep.
The Potential for Pharmacokinetic Interactions Between Cannabis Products and Conventional Medications
Authors: Qian Yuli , Gurley Bill J. , Markowitz John S. 
Published: August 2019

Abstract

Purpose
Increased cannabis use and recent drug approvals pose new challenges for avoiding drug interactions between cannabis products and conventional medications. This review aims to identify drug-metabolizing enzymes and drug transporters that are affected by concurrent cannabis use and, conversely, those co-prescribed medications that may alter the exposure to one or more cannabinoids.

Methods
A systematic literature search was conducted utilizing the Google Scholar search engine and MEDLINE (PubMed) database through March 2019. All articles describing in vitro or clinical studies of cannabis drug interaction potential were retrieved for review. Additional articles of interest were obtained through cross-referencing of published bibliographies.

Findings
After comparing the in vitro inhibition parameters to physiologically achievable cannabinoid concentrations, it was concluded that CYP2C9, CYP1A1/2, and CYP1B1 are likely to be inhibited by all 3 major cannabinoids Δ9-tetrahydrocannabinol (THC), cannabidiol (CBD), and cannabinol (CBN). The isoforms CYP2D6, CYP2C19, CYP2B6, and CYP2J2 are inhibited by THC and CBD. CYP3A4/5/7 is potentially inhibited by CBD. Δ9-Tetrahydrocannabinol also activates CYP2C9 and induces CYP1A1. For non-CYP drug-metabolizing enzymes, UGT1A9 is inhibited by CBD and CBN, whereas UGT2B7 is inhibited by CBD but activated by CBN. Carboxylesterase 1 (CES1) is potentially inhibited by THC and CBD. Clinical studies suggest inhibition of CYP2C19 by CBD, inhibition of CYP2C9 by various cannabis products, and induction of CYP1A2 through cannabis smoking. Evidence of CBD inhibition of UGTs and CES1 has been shown in some studies, but the data are limited at present. We did not identify any clinical studies suggesting an influence of cannabinoids on drug transporters, and in vitro results suggest that a clinical interaction is unlikely.

Conclusions
Medications that are prominent substrates for CYP2C19, CYP2C9, and CYP1A2 may be particularly at risk of altered disposition by concomitant use of cannabis or 1 or more of its constituents. Caution should also be given when coadministered drugs are metabolized by UGT or CES1, on which subject the information remains limited and further investigation is warranted. Conversely, conventional drugs with strong inhibitory or inductive effects on CYP3A4 are expected to affect CBD disposition.
Physiology of cerebrospinal fluid circulation
Authors: Shapey Jonathan , Toma A. , Saeed S.R. 
Published: August 2019

Purpose of review
This article describes the physiology of cerebrospinal fluid (CSF). We review current evidence and new concepts relating to CSF physiology with respect to CSF secretion, circulation and resorption and we highlight key pathophysiological associations including the relationship between CSF and intracranial pressure.

Recent findings
CSF secretion occurs primarily via the choroid plexus. Various transport mechanisms facilitate CSF secretion but the role Aquaporins play in this process is a recent discovery and an area of ongoing research. CSF circulation is a dynamic process but the importance of the perivascular ‘Glymphatic system’ and extraarachnoidal pathways of resorption are relatively new concepts.

Summary
CSF physiology is dependent on various interacting factors and is critical for normal brain development and function.
The Impact of Focused Cardiac Ultrasound Performed by Pediatric Intensivists
Authors: Rato João , Camilo Cristina , Boto Leonor , Rios Joana , Abecasis Francisco , Vieira Marisa 
Published: August 2019

Objectives
Focused cardiac ultrasound is an echocardiographic method used by medical intensivists for fast and reliable hemodynamic assessment. Prospective studies and guidelines have defined its role in adult critical care. Data regarding its use in pediatric critical care are scarce. This is the first prospective study that aims to evaluate its impact in this setting.

Methods
This is a single-center prospective study performed in a tertiary referral hospital pediatric intensive care unit (PICU). For a period of 6 months, when performing an echocardiogram, pediatric intensivists filled out a questionnaire that included the patient's clinical data and indication for the examination. The intensivists had to record both the clinical impression regarding that indication and therapeutic plan before and after the echocardiogram. All the patients with an echocardiogram performed by the pediatric intensive care unit medical staff were included.

Results
There were 80 echocardiograms performed on 35 patients during the study period. The most common patient diagnostic groups were respiratory infections (38%, n = 30) and septic shock (21%, n = 17). The main indication for the examination was assessment of intravascular volume status and left ventricular systolic function. After the echocardiogram, the clinical impression was maintained in 49% (n = 39) and changed in 44% (n = 35). There were new findings unrelated to the initial evaluation in 7% (n = 6). The planned treatment was maintained in 55% (n = 44) and changed in 45% (n = 36).

Conclusions
The echocardiogram changed the clinical impression and therapeutic plan in almost half of the patients. These data show the value of focused cardiac ultrasound as a diagnostic and hemodynamic monitoring tool in pediatric intensive care and emphasize the importance of a rigorous training program.
Familial relationships in electronic health records (EHR) v2
Authors: Liu Zhouzerui , Tatonetti Nicholas 
Published: August 2019

AbstractHeritability is an important statistic for evaluating genetic contribution to phenotypes. Estimating heritability, however, requires a laborious recruitment of a large number of relatives. Electronic health records (EHR) contain massive relative information in emergency contact forms. Recently, we presented RIFTEHR, an algorithm for extracting relationships from EHR. Here, we present an updated version and reconstructed 4.2 million familial relationships from the latest New York-Presbyterian/Columbia University Irving Medical Center (CUIMC) EHR system. The number of updated relationships is 30 percent more than the last version. We present a new implementation of RIFTEHR, which runs in linear time, thus largely improves the speed of the algorithm. We also present a data encryption method, to protect patient privacy in running the algorithm. These resources can be used for generalized use of familial relationships from EHR in genetic studies.
Preliminary findings of single session of noninvansive brain stimulation over parietal lobe and performance on spatial memory task
Authors: Čolić V Marija , Konstantinović Uroš , Bjekić Jovana , Filipović R Saša 
Published: August 2019

AbstractSpatial memory relies on efficient encoding, storage and retrieval of spatial information, which enables us to remember paths or locations of objects in everyday life. Moreover, this type of memory has been shown to decline with age and various neurodegenerative disorders. Parietal cortex has been shown to play an important role in the formation of short-term representations of spatial information. The aim of the current study was to test the possibility of immediate and long-term spatial memory enhancement, by increasing excitability of parietal posterior cortex. We used transcranial direct current stimulation (tDCS) over posterior parietal cortex in a placebo-controlled cross-over study. Participants received anodal (1.5 mA) or sham tDCS stimulation over P4 site (10-20 EEG system) for 20 minutes in two separate sessions. Immediately after stimulation, participants completed a spatial maze task, which consisted of learning block, 2D recall, and 3D recall. Spatial memory performance was tested 24 hours and 7 days after stimulation, to assess potential long-term effects. We found no significant effects of anodal stimulation on spatial memory performance either on immediate or delayed recall. This was the case with both, 2D and 3D spatial memory recall. Our results are in line with some studies that suggest that single brain stimulation sessions do not always produce effects on cognitive functions.
ATLAS: a Snakemake workflow for assembly, annotation, and genomic binning of metagenome sequence data
Authors: Kieser Silas , Brown Joseph , Zdobnov Evgeny M. , Trajkovski Mirko , McCue Lee Ann 
Published: August 2019

AbstractBackgroundMetagenomics and metatranscriptomics studies provide valuable insight into the composition and function of microbial populations from diverse environments, however the data processing pipelines that rely on mapping reads to gene catalogs or genome databases for cultured strains yield results that underrepresent the genes and functional potential of uncultured microbes. Recent improvements in sequence assembly methods have eased the reliance on genome databases, thereby allowing the recovery of genomes from uncultured microbes. However, configuring these tools, linking them with advanced binning and annotation tools, and maintaining provenance of the processing continues to be challenging for researchers.ResultsHere we present ATLAS, a software package for customizable data processing from raw sequence reads to functional and taxonomic annotations using state-of-the-art tools to assemble, annotate, quantify, and bin metagenome and metatranscriptome data. Genome-centric resolution and abundance estimates are provided for each sample in a dataset. ATLAS is written in Python and the workflow implemented in Snakemake; it operates in a Linux environment, and is compatible with Python 3.5+ and Anaconda 3+ versions. The source code for ATLAS is freely available, distributed under a BSD-3 license.ConclusionATLAS provides a user-friendly, modular and customizable Snakemake workflow for metagenome and metatranscriptome data processing; it is easily installable with conda and maintained as open-source on GitHub at https://github.com/metagenome-atlas/atlas.