bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hydroxypterocarpans with estrogenic activity in Aguaje, the fruit of Mauritia flexuosa (Peruvian moriche palm)
Authors: Shimoda Hiroshi , Takeda Shogo , Takarada Toru , Kato Yurina , Shimizu Norihito , Toda Kazuya , Nakamura Masafumi , Hanada Hiroshi , Nakamura Seikou , Matsuda Hisashi 
Published: May 2019

Background: Phytoestrogens in edible plants, including soybean isoflavones and pomegranates, have been used for alleviation of premenopausal/postmenopausal syndromes and osteoporosis. Mauritia flexuosa (moriche palm) is grown in Peru and Brazil for its edible fruit that is said to contain phytoestrogens, but the relevant estrogenic compounds have not been identified. We investigated the constituents of moriche palm fruit extract and evaluated their estrogenic ability.Materials and methods: Ethyl acetate fraction of dried moriche palm was purified by column chromatography and HPLC chromatography. To evaluate estrogenic activity, we performed [1] simulation of binding to the human estrogen receptor (ER), [2] investigation of the proliferative effect on MCF-7 cells, and [3] the estrogen-chemically activated luciferase gene expression (E-CALUX) assay.Results: Two hydroxypterocarpans were isolated including lespeflorin G8 (LF) and 8-hydroxyhomopterocarpan (8-HHP). The binding affinity of LF to ERa was higher than that of 8-HHP, with inhibition constants of 81.9 nM and 1.99 mM, respectively. However, LF and 8-HHP exhibited a similar proliferative effect on MCF-7 cells at 10 mM. The E-CALUX assay demonstrated that LF is a full ER agonist and 8-HHP is a partial agonist.Conclusion: LF was identified as a major estrogenic compound in the fruit of Mauritia flexuosa.Keywords: Mauritia flexuosa, moriche palm, lespeflorin G8, homopterocarpan, estrogenic activity, MCF-7, E-CALUX
Challenges to and Facilitators of Recruitment to an Alzheimer’s Disease Clinical Trial: A Qualitative Interview Study
Authors: Clement Clare , Selman Lucy E. , Kehoe Patrick G. , Howden Beth , Lane J. Athene , Horwood Jeremy 
Published: May 2019

Background: Low participation in clinical trials is a major challenge to advancing clinical Alzheimer’s disease (AD) research and care. Factors influencing recruitment to AD trials are not fully understood. Objective: To identify barriers to, and facilitators of, recruitment in a UK multi-center, secondary care AD trial (Reducing pathology in Alzheimer’s Disease through Angiotensin TaRgeting (RADAR) trial) and implications for improving recruitment to AD trials. Methods: Semi-structured qualitative telephone interviews with a purposive sample of 17 trial site staff explored the RADAR trial recruitment pathway and views and experiences of recruitment. Interviews were analyzed thematically. Results: Diagnostic and care pathways hindered identifying patients with mild-moderate AD, with a lack of up-to-date patient records and data access problems affecting screening. Research is not routinely embedded in AD care but facilitated recruitment when it was. Clinicians’ and patients’ favorable view of the trial purpose facilitated recruitment, although the complexity of participant information sheets and requirement for study companion created challenges. Conclusion: These findings have important implications for the design of future AD trials and for planning how to best interface with clinical commitments to ensure sufficient and timely recruitment. Challenges to AD trial recruitment can occur at care pathway, clinician, and patient and companion levels. Recruitment can be facilitated by: improving diagnostic processes and systems for recording and sharing patient information, embedding research into routine patient care, collaborating with a range of services to identify and approach eligible patients, training and engaging trial staff, and providing patients with clear and concise study information.
Disiplin Soruşturmalarında Hukuka Aykırı Deliller
Authors: Fiş Üstün Gül 
Published: May 2019

Kamu görevlilerinin çalıştıkları kurumun düzenini bozan veya kurumun sunduğu hizmetin düzgün
yürütülmesini engelleyen faaliyetleri disiplin hukukunun konusunu oluşturmaktadır. Disiplin hukuku
söz konusu ihlalleri gerçekleştiren kamu görevlisinin daha dikkatli ve özenli davranmasını sağlayacak,
mali haklarına ve mesleki statüsüne etki yapmaya yönelik disiplin cezalarını ve bu cezalara ilişkin
başvurulabilecek yolları ve disiplin cezasının tesisi için gereken disiplin soruşturma sürecini konu
almaktadır.
Disiplin soruşturmasını yürüten soruşturmacı; soruşturma konusuyla sınırlı olmak üzere her nevi
evrakı incelemeye, ilgili kurumlardan ve kişilerden bilgi ve belge almaya, tanık dinlemeye, mahallinde
keşif yapmaya, hakkında soruşturma yapılan memurun savunmasını almaya, soruşturma raporu
düzenlemeye yetkilidir. Ancak, soruşturmacıya tanınan bu yetkilerin kullanımı sırasında veya
soruşturma raporunun tesisi sırasında yapılan değerlendirmelerde bazı hatalar, hukuka aykırılıklar
meydana geldiği de görülmektedir.
Danıştay’ ın bir kısım kararlarında, disiplin hukukunun bağımsız olduğu, ceza soruşturmalarından
disiplin soruşturmalarını bağlamadığı ilkeleri zikredilerek, hukuka aykırı delillerin disiplin
soruşturmalarında kullanılmasına engel olmadığı yönünde hükümler tesis edilmiştir. Ancak, Danıştay
yakın dönemlerde kararlarını değiştirmiş, Anayasamızın 38. maddesinde öngörülen hukuka aykırı
elde edilen bulguların delil olarak kullanılmamasını yönündeki ilkenin disiplin soruşturmalarında
uygulanması mümkün hale gelmiştir.
On the relationship among birds and Trema micrantha in montane forests of Hispaniola
Authors: Latta Steven C. 
Published: May 2019

Avian frugivores are of great interest to ecologists because they play an important role in ecosystem functioning, and can serve as important components in habitat restoration. In the Neotropics, observational studies have demonstrated the importance of a variety of fruit trees to numerous bird species, but undoubtedly other tree species exist that are a key resource for birds. I explored the relationship between Trema micrantha (L.) Blume, which produces superabundant fruit nearly continuously, and its disperser assemblage in Hispaniolan pine forest and montane broadleaf forest in the Sierra de Bahoruco, Dominican Republic. In 174 hours of observation at sixteen trees I recorded 513 visits by nineteen species of birds. Birds did not visit Trema in numbers reflecting their relative abundance in each habitat. The most frequent consumer of Trema fruit was the migratory Cape May Warbler, Setophaga tigrina (Gmelin, 1789), but other frequent visitors included the Black-throated Blue Warbler, S. caerulescens (Gmelin, 1789), and the endemic Palmchat, Dulus dominicus (Linnaeus, 1766), and Hispaniolan Highland-Tanager, Xenoligea montana (Chapman, 1917). I recorded 85 aggressive interactions among nine species of birds in Trema trees, with female Cape May Warblers involved in most of these. There was no evidence that Trema was dependent on any one species of bird for dispersal of its seeds, and despite the large proportion of visits by the Cape May Warbler, I found no evidence that any species of bird was dependent upon fruit from Trema. Rather, because male Cape May Warblers dominate females and defend nectar sources in these habitats, I suggest that for female Cape May Warblers, these scattered Trema trees represent a known, reliable, and accessible source of food which they can defend. Trema trees will benefit these bird species as a food resource, but may also function as a target for many other birds moving across the landscape, thereby facilitating the dispersal of a wider variety of seeds and the restoration of deforested sites.
Distribución y abundancia del pez león Pterois volitans en la zona costera de uso turístico de Holguín, Cuba
Authors: Reynaldo Enrique , Vega Antonio , Fernández Alejandro , Cruz José , Córdova Elier , Cruz Pedro 
Published: May 2019

En Cuba, a partir del 2007, se detectó la presencia de Pterois volitans, comúnmente llamado Pez León, especie invasora causante de grandes daños a comunidades ictiológicas autóctonas en diferentes regiones del mundo. Este trabajo se propuso determinar la distribución y abundancia del Pez León en diferentes sitios de muestreo en la zona costera de uso turístico de Holguín. El estudio se realizó en ocho campañas de muestreo durante el período abril-noviembre de 2016. Se seleccionó un total de siete sitios de monitoreo distribuidos en dos municipios de la provincia Holguín (Rafael Freyre y Banes). Se determinó la abundancia promediando los valores de cada recorrido lineal (individuo por cada 100 m2). Se determinó la talla y el peso por estación de muestreo con una cinta métrica y una balanza digital. La comparación múltiple de medias se realizó por PERMANOVA con 10 000 permutaciones empleando la distancia euclidiana. Se registró un total de 365 individuos. El sitio con mayor densidad fue Playa Blanca, con 12.42 ind/100 m2 y el de menor abundancia playa Don Lino, con 3.66 ind/100 m2, detectando solamente diferencia estadística entre este sitio con el resto de los sitios monitoreados. El mes con mayor densidad en el año de estudio fue abril, con 13.14 ind/100 m2, registrándose diferencias estadísticas significativas en cuanto a la abundancia entre este y los meses de mayo (6.42 ind/100 m2), julio (7.28 ind/100 m2) y agosto (6.71 ind/100 m2). La comparación de la abundancia poblacional entre años del Pez León, registrada en el 2016 con años anteriores demuestra diferencia estadística entre los años 2013 (p<0.001) y 2012 (p<0.01).
Checklist of the centipedes (Chilopoda) of Hispaniola
Authors: Martínez-Muñoz Carlos A. , Perez-Gelabert Daniel E. 
Published: May 2019

Ten years have passed since the last checklist of Hispaniolan Chilopoda was done and the last bibliographic compendium was published. In this work we expand the former list of species and bibliography, update the taxonomic classification and provide an assessment on Chilobase records. A new intensive literature review was performed and both recent and formerly overlooked myriapodological works were included. The treatment of supraspecific taxonomic ranks was updated and follows Chilobase 2.0. This catalogue lists 4 fossil taxa as well as 24 extant species of centipedes from Hispaniola, 9 of which are endemic. For each extant species considered, there is information on Hispaniolan synonymies and geographic distribution. Included are some clarifications on synonymies and locality problems, and species with uncertain taxonomic status are indicated. Chilobase 2.0 was tested for completeness and accuracy. We propose several updates, grouped by incorrect species records, records not backed by known literature and species not under their currently accepted synonym. We also recommend chilopodologists to maintain active collaboration and send their updates to this useful database.
Adopsi Inovasi Pemanfaatan Kotoran Ternak Sapi Untuk Pembuatan Pupuk Bokashi di Kelompoktani “Usaha Bersama” Desa Sekarmojo Kecamatan Purwosari Kabupaten Pasuruan
Authors: Farid Abdul , Mudita IGN , Pudjianto Tri 
Published: May 2019

Pemanfaatan kotoran ternak sapi belum optimal, petani lebih tergantung pada pupuk anorganik. Selain itu masalah yang dihadapi petani saat ini yaitu kelangkaan pupuk. Untuk mengatasi hal tersebut, salah satu potensi yang bisa dimanfaatkan yaitu pembuatan pupuk bokashi dari kotoran ternak sapi. Fungsi pupuk bokashi antara lain meningkatkan kesuburan tanah, pertumbuhan dan produksi tanaman, pembuatan mudah, biaya murah dan bahan mudah diperoleh. Tujuan penelitian ini adalah: 1) untuk mengetahui tingkat adopsi inovasi petani terhadap pemanfaatan kotoran ternak sapi untuk pembuatan pupuk bokashi, 2) untuk mengetahui pengaruh karakteristik petani (umur, tingkat pendidikan, luas usahatani dan pengalaman berusahatani) terhadap adopsi teknologi pemanfaatan kotoran ternak sapi untuk pembuatan pupuk bokashi, 3) untuk menyusun rancangan penyuluhan yang tepat tentang pemanfaatan kotoran ternak sapi untuk pembuatan pupuk bokashi. Hasil penelitian menunjukkan bahwa tingkat adopsi petani di Desa Sekarmojo masih rendah, dari 30 responden hanya ada 4 responden yang sudah menerapkan adopsi. Dengan taraf signifikan (α) 0,05, umur berpengaruh yang signifikan terhadap adopsi pemanfaatan kotoran ternak sapi untuk pembuatan pupuk bokashi dengan nilai signifikansi 0,008, namun mempunyai arah ramalan negatif. Tingkat pendidikan berpengaruh positif yang signifikan terhadap tingkat adopsi dengan nilai signifikansi 0,004. Luas usahatani tidak berpengaruh signifikan terhadap tingkat adopsi dengan nilai signifikansi 0,509. Sedangkan pengalaman berusahatani berpengaruh yang signifikan terhadap tingkat adopsi pemanfaatan kotoran ternak sapi untuk pembuatan pupuk bokashi dengan nilai signifikansi 0,000 namun mempunyai arah ramalan negatif. Penyuluhan tentang pemanfaatan kotoran ternak sapi untuk pembuatan pupuk bokashi menggunakan metode dan teknik ceramah, diskusi, demonstrasi cara. Media yang digunakan folder dan benda sesungguhnya.
ANALISIS GREEN INOVATION DAMPAKNYA TERHADAP KEUNGGULAN BERSAING PRODUK DAN KINERJA PEMASARAN (STUDI EMPIRIK PADA UKM BATIK CIWARINGIN KABUPATEN CIREBON)
Authors: Fitriani Lili Karmela 
Published: May 2019

This paper examines the relationship between green product innovation, green process innovation, competitive advantage of product and market performance in the SMEs Ciwaringin batik Cirebon West Java. A survey of 93 SMEs batik provides the basis for the empirical investigation. The relationships between the green innovation product, competitive advantage of product and market performance are examined using stepwise regression.The findings show that green product innovation not contributes positively to competitive advantage of product and market performance. Another findings of this study is that the impact of green process innovation contributes positively to competitive
advantage of product but not to market performance in the SMEs Ciwaringin batik. Competitive advantage of product has impact to market performance. This paper also discusses the recomendations of the results.
ANALISIS PENGARUH BENCANA BANJIR DI JAKARTA TERHADAP RETURN INDEKS SAHAM SEKTORAL YANG TERDAFTAR DI BURSA EFEK INDONESIA PERIODE 2000-201
Authors: Natasha Evelyn , Sumami Sumami 
Published: May 2019

This study aimed to analyze the effect of flood that occurred in Jakarta toward the return of sectoral stock indices listed on the Indonesia Stock Exchange in the period 2000-2013.
The hypothesis of this study is that there are significant effect of floods occurred in Jakarta toward the return of sectoral stock indices listed on the Indonesia Stock Exchange in the period 2000-2013.The data used in this study are secondary data, daily closing
prices of sectoral indices in 2000 and 2013 were obtained from the library of the Indonesia Stock Exchange. While the analysis is the analysis of time series with GARCH models. The results of this study are that there are significant effect of floods occurred in
Jakarta toward the return of sectoral indices, which 4 of the 10 sectors in 2002, 3 sector in 2007, and 2 sector in 2013. The sectors that are affected significantly are the consumer goods sector, property and real estate, finance, and trade, services and investment.
ANALISIS PENGARUH KEPUASAN KERJA, IKLIM ORGANISASI KOMITMEN ORGANISASI TERHADAP EFEKTIVITAS ORGANISASI : ORGANIZATIONAL CITIZENSHIP BEHAVIOR (OCB) SEBAGAI MEDIASI
Authors: Harri Muhammad 
Published: May 2019

<em>This study aims to determine the influence of job satisfaction, organizational climate, organizational commitment and organizationa citizenship behavior on organizational effectiveness in PT. Cosmo Makmur Indonesia. Population and sample ini this study in the number of employee of 169 people. Analysis the data used was the validity and reliability test with path analysis. From the analysis, the coefficient of the determinan (R<sup>2</sup>) noted that organizational citizenship behavior influenced by job satisfaction, organizational climate, organizational commitment by 87% and the ramining 13% was influence by other factors which not included in the model. Job satisfaction significantly effect of 3.540, organizational climate siginificantly effect of 2,889 and organizational commitment significantly effect of 2,108 and organizational citizenship behavior significantly effect of 6.862. The analysis of the test, yhe coefficient of the determination noted that the organizational effectiveness was influenced by job satisfaction, organizational climate, organizational commitment, and organizational citizenship behavior</em>
Colangite crônica associada à infestação de trematódeo por platynosomum fastosum, concomitante à vesícula biliar dupla em um gato
Authors: Basso Karina Maria , Arenales Alexandre , Filho Nazilton de Paula Reis , Cardoso Mauro José Lahm , Calderón Celmira 
Published: May 2019

Este trabalho tem o objetivo de relatar um caso de um felino de cinco anos, sem raça definida, apresentando icterícia intensa, petéquias e equimoses cutâneas generalizadas, aumento da enzima ALT, aumento de colesterol sérico e diminuição de proteínas plasmáticas. Foi instituído tratamento médico, entretanto o animal morreu dois dias após a intervenção clínica. No exame anatomopatológico observou-se colangite crônica associada à infestação de trematódeo Platynosomum fastosum e vesícula biliar dupla verdadeira. Conclui-se que alterações anatômicas associadas à infestação por parasitas podem agravar significativamente o quadro clínico de colangite crônica e devem sempre ser consideradas no plano diagnóstico.
Alterações da medula óssea e a importancia do mielograma no diagnóstico da ehrlichiose monocítica canina
Authors: Caxito Marília Salgado , Rodrigues Fernanda Panseri , Taques Isis Indaiara Gonçalves Granjeiro , Aguiar Daniel Moura de , Takahira Regina Kiomi , Paes Antônio Carlos 
Published: May 2019

A Ehrlichiose Monocítica Canina (EMC) é uma doença multissistêmica e de alta incidência. Contudo, a patogenia da enfermidade ainda não está totalmente esclarecida. Infiltrações plasmocitárias e linfoplasmocitárias são observadas em grande parte dos órgãos de animais acometidos, inclusive na medula óssea. Esses infiltrados sugerem que a maioria das lesões patológicas identificadas na fase crônica pode ser consequência do processo inflamatório originado no início da infecção. Este trabalho tem por objetivo destacar a importância da avaliação medular de cães com EMC. A maior compreensão das alterações medulares na fase aguda poderia esclarecer a origem das alterações observadas na fase crônica. Mais estudos são necessários para verificar se a patogenia da EMC está relacionada apenas a processos imunomediados ou se também há agressões diretas de Ehrlichia canis às células precursoras. Elucidar os mecanismos fisiopatogênicos de E. canis poderia melhorar a terapêutica instituída como também o prognóstico de animais gravemente acometidos
Endocardite vegetativa em leitões causada por streptococcus suis sorotipo 9
Authors: Gaggini Thais Schwarz , Bierhals Thomas , Machado Glauber , Bragança Wagner C. G. , Bortolozzo Fernando Pandolfo 
Published: May 2019

A endocardite vegetativa é uma importante alteração do endocárdio do suíno, quase sempre associada a infecções sistêmicas provocadas por bactérias. Foi identificado como agente causador de endocardite vegetativa Streptococcus suis sorotipo 9, em leitões de 7 a 10 e 30 dias de idade. Esse caso mostrou-se de interesse devido à idade dos animais acometidos e o sorotipo identificado. Por ser uma lesão de causa crônica, a endocardite vegetativa em leitões jovens é considerada incomum, não sendo relatada anteriormente na literatura. Além disso, não foi encontrado relato que relacione o sorotipo 9 como causador de endocardite vegetativa em leitões jovens.
KAJIAN PERBAIKAN SUBGRADE DARI TANAH EKSPANSIF MENGGUNAKAN SPENT CATALYST RCC 15 DAN ABU BATOK KELAPA SAWIT
Authors: Hermawan Totok , . Syahril 
Published: May 2019

Hasil pengujian pada lapisan Subgrade yang dilakukan di ruas jalan tol Cisumdawu khususnya pada STA 13+500 tergolong pada jenis tanah ekspansif. Kondisi Subgrade tersebut jika tidak segera diperbaiki maka dapat mengakibatkan berbagainya jenis kerusakan pada perkerasannya. Dalam penelitian perbaikan Subgrade yang dilakukan adalah menggunakan metode stabilisasi dengan Abu Batok Kelapa Sawit dan Spent Catalyst RCC 15. Penelitian ini bertujuan untuk mengevaluasi sejauh mana pengaruh penambahan Abu Batok Kelapa Sawit dan Spent Catalyst RCC 15 terhadap kembang susut dan daya dukung sebagai lapisan Subgrade konstruksi perkerasan ruas jalan tol Cisumdawu. Penelitian ini menghasilkan beberapa kesimpulan yaitu (1) Terjadi penurunan nilai untuk kadar air optimum, Plasticity Index, Swelling Potential dan Swelling Pressure. (2) Terjadi Kenaikan nilai untuk Berat Isi Kering, CBR Unsoaked, CBR Soaked, CBR Peram, Permeabilitas, Ca-dd dan K-dd. (3) Tercapainya campuran bahan stabilisasi yang dapat digunakan sebagai perbaikan Subgrade pada tanah ekspansif untuk standar minimal Subgrade lapisan perkerasan jalan. (4) Belum tercapainya nilai yang optimum pada campuran bahan stabilisasi yang digunakan terhadap perubahan nilai karakteristik Subgrade. (5) Hasil pengujian secara statistik yang dilakukan didapatkan suatu hubungan yang yang berarti secara statistic.
Studi Perencanaan Mitigasi Bencana Tsunami di Daerah Wisata Pantai Tablolong
Authors: Nahak Priska Gardeni , Djunaedi Djunaedi , Wonlele Tedi 
Published: May 2019

Pantai Tablolong merupakan salah pantai tujuan wisata yang terletak di Kecamatan Kupang Barat, Kabupaten Kupang. Letak Pantai Tablolong adalah di bagian ujung Barat dari Pulau Timor sehingga sangat rentan terhadap bahaya Tsunami. Penelitian ini menggunakan metode deskripsi dengan melakukan observasi dan kajian secara langsung di lapangan terhadap berbagai kondisi guna mengetahui seberapa besar dampak dan kerusakan yang mungkin terjadi. Penelitian ini bertujuan untuk: a) Menghitung waktu yang diperlukan oleh gelombang tsunami dari pusat patahannya ke Pantai Tablolong. b) Memperkirakan lokasi atau jarak penempatan alat detector peringatan dini. c) Mengkaji situasi yang ada di lapangan terhadap dampak yang akan ditimbulkan oleh gelombang tsunami. Berdasarkan hasil penelitian diketahui bahwa: waktu datang gelombang tsunami adalah 13,45 menit setelah terjadi dislokasi.; Lokasi pemasangan alat detector peringatan dini, yaitu pada jarak 31,6 km dari garis pantai, sehingga memberikan waktu sekitar 12 menit bagi wisatawan untuk menyelamatkan diri.; Tinggi gelombang pada saat mencapai pantai adalah 18 m, sehingga tinggi run up gelombangnya adalah 40,7 m.; Daerah yang terkena gelombang tsunami secara langsung adalah daerah di pantai selatan pulau Timor dan pulau Semau yang memiliki elevasi di bawah 40,7 m.; Pantai wisata Tablolong hanya akan terkena dampak tsunami berupa refleksi dari gelombang tsunami terhadap pulau Semau.
Tracking the Footprints of the Radio Pulsar B1727–47: Proper Motion, Host Supernova Remnant, and the Glitches
Authors: Shternin P. , Kirichenko A. , Zyuzin D. , Yu M. , Danilenko A. , Voronkov M. , Shibanov Yu. 
Published: May 2019

Abstract
The bright radio pulsar B1727−47, with a characteristic age of 80 kyr, was among the first pulsars discovered 50 yr ago. Using regular timing observations and its interferometric positions at three epochs, we measured, for the first time, the pulsar proper motion of 151 ± 19 mas yr−1. At the dispersion measure distance of ≳2.7 kpc, this would suggest a record transverse velocity of the pulsar of ≳1900 km s−1. However, a backward extrapolation of the pulsar track to its birth epoch points remarkably close to the center of the evolved nearby supernova remnant RCW 114, which suggests genuine association of the two objects. In this case, the pulsar is substantially closer (∼0.6 kpc) and younger (∼50 kyr), and its velocity (∼400 km s−1) is compatible with the observed pulsar velocity distribution. We also identified two new glitches of the pulsar. We discuss implications of our results for the properties of the pulsar and the remnant.