bluuebunny/crossref_metadata_2025_split huggingface dataset:
Brain volume is a better biomarker of outcomes in ischemic stroke compared to brain atrophy
Authors: Alhadid Kenda , Regenhardt Robert W. , Rost Natalia S. , Schirmer Markus D. 
Published: October 2024

ObjectiveThis study aimed to determine whether brain volume at the time of ischemic stroke injury is a better biomarker for predicting functional outcomes than brain atrophy.BackgroundBrain parenchymal fraction (BPF) has been used as a surrogate measure of global brain atrophy and a neuroimaging biomarker of brain reserve in studies evaluating clinical outcomes after brain injury. Brain volume itself is affected by natural aging, cardiovascular risk factors, and biological sex, among other factors. Recent studies have shown that brain volume at the time of injury can influence functional outcomes, with larger brain volumes being associated with better outcomes.MethodsAcute ischemic stroke cases at a single center between 2003 and 2011, with neuroimaging obtained within 48 h of presentation were eligible for the study. Functional outcomes represented by the modified Rankin Scale (mRS) score at 90 days post-admission (mRS score ≤ 2 deemed a favorable outcome) were obtained through patient interviews or per chart review. Deep learning–enabled automated segmentation pipelines were used to calculate brain volume, intracranial volume, and BPF on the acute neuroimaging data. Patient outcomes were modeled through logistic regressions, and a model comparison was conducted using the Bayes information criterion (BIC).ResultsA total of 467 patients with arterial ischemic stroke were included in the analysis, with a median age of 65.8 years and 65.3% of the participants being male. In both models, age and a larger stroke lesion volume were associated with worse functional outcomes. Higher BPF and a larger brain volume were associated with favorable functional outcomes; however, a comparison of both models suggested that the brain volume model (BIC = 501) better explains the data than the BPF model (BIC = 511).ConclusionThe extent of global brain atrophy (and its surrogate biomarker BPF) has been regarded as an important biomarker for predicting functional post-stroke outcomes and resilience to acute injury. In this study, we demonstrate that a higher global brain volume at the time of injury better explains favorable functional outcomes, which can be directly measured in a clinical setting.
Genomic Characterization of Lactiplantibacillus plantarum Strains: Potential Probiotics from Ethiopian Traditional Fermented Cottage Cheese
Authors: Gizachew Seyoum , Engidawork Ephrem 
Published: October 2024

Background: Lactiplantibacillus plantarum is a species found in a wide range of ecological niches, including vegetables and dairy products, and it may occur naturally in the human gastrointestinal tract. The precise mechanisms underlying the beneficial properties of these microbes to their host remain obscure. Although Lactic acid bacteria are generally regarded as safe, there are rare cases of the emergence of infections and antibiotic resistance by certain probiotics. Objective: An in silico whole genome sequence analysis of putative probiotic bacteria was set up to identify strains, predict desirable functional properties, and identify potentially detrimental antibiotic resistance and virulence genes. Methods: We characterized the genomes of three L. plantarum strains (54B, 54C, and 55A) isolated from Ethiopian traditional cottage cheese. Whole-genome sequencing was performed using Illumina MiSeq sequencing. The completeness and quality of the genome of L. plantarum strains were assessed through CheckM. Results: Analyses results showed that L. plantarum 54B and 54C are closely related but different strains. The genomes studied did not harbor resistance and virulence factors. They had five classes of carbohydrate-active enzymes with several important functions. Cyclic lactone autoinducer, terpenes, Type III polyketide synthases, ribosomally synthesized and post-translationally modified peptides-like gene clusters, sactipeptides, and all genes required for riboflavin biosynthesis were identified, evidencing their promising probiotic properties. Six bacteriocin-like structures encoding genes were found in the genome of L. plantarum 55A. Conclusions: The lack of resistome and virulome and their previous functional capabilities suggest the potential applicability of these strains in food industries as bio-preservatives and in the prevention and/or treatment of infectious diseases. The results also provide insights into the probiotic potential and safety of these three strains and indicate avenues for further mechanistic studies using these isolates.
IMMUNOLOGICAL AND HEMATOLOGICAL STATUS PROFILE IN TUBERCULOSIS-HUMAN IMMUNODEFICIENCY VIRUS COINFECTED PATIENTS
Authors: Fajrunni'mah Rizana , Febriyana Niniek Dwi 
Published: October 2024

Infeksi oleh Human Immunodeficiency Virus (HIV) merupakan masalah di seluruh dunia termasuk Indonesia. Tuberkulosis (TB) adalah infeksi oportunistik tersering pada penderita AIDS. Status imun pada penderita terinfeksi HIV dapat dinilai melalui pemeriksaan jumlah absolut limfosit T CD4+, dan ini merupakan standar untuk menilai dan menentukan derajat imunodefisiensi. Penurunan progresif limfosit T CD4+ berhubungan dengan progresifitas penyakit. Penelitian ini bertujuan mengetahui profil status imunologis yang dilihat dari jumlah CD4 dan hematologi yang dilihat dari jumlah leukosit, hitung jenisnya, hemoglobin, laju endap darah, dan trombosit. Penelitian ini menggunakan rancangan kuantitatif dengan desain analitik observasional (cross sectional).Jumlah data yang diambil sebanyak 45 data. Data dianalisis menggunakan analisis korelasi. Jumlah CD4+ pasien ko-infeksi TB-HIV terbanyak menunjukkan imunodefisiensi berat (jumlah CD4+ <200 sel/ mm3) yaitu 73,3% pasien dengan rerata 118,4 sel/ mm3. Terdapat 86,5% mengalami anemia. Hitung jumlah dan jenis leukosit terbanyak yaitu jumlah leukosit normal sebanyak 59,5%, sebanyak 61,5% mengalami neutrofilia, sebanyak 65,4% mengalami limfopenia, monosit dalam rentang normal yaitu sebesar 57,7%. Sebanyak 73,7% mengalami peningkatan dengan rerata laju endap darah pasien mencapai 46,58 mm/jam. Jumlah trombosit terbanyak dalam rentang normal yaitu sebesar 68,6%. Terdapat korelasi yang signifikan antara kadar hemoglobin, hitung jumlah neutrofil, limfosit, dan monosit dengan hitung jumlah CD4+ dengan nilai p berturut-turut yaitu 0,001; 0,000; 0,000; 0,012. Status imunologis dan hematologi pasien koinfeksi TB-HIV mengalami penurunan, dan terdapat korelasi yang signifikan antara kedua profil tersebut, sehingga perlu meningkatkan pemeriksaan laboratorium secara menyeluruh.
INCREASING NUTRITIONAL KNOWLEDGE AND FIBER INTAKE OF OVERWEIGHT ADOLESCENTS THROUGH WEB GAME-BASED BALANCED NUTRITION TUMPENG
Authors: Buamona Nur Sitra , Anantanyu Sapja , Suminah Suminah 
Published: October 2024

Prevalensi kegemukan pada remaja berdasarkan data Kementrian Kesehatan Republik Indonesia meningkat dari 2013 sebesar 7,3% menjadi 9,5% pada tahun 2018. Masalah gizi perlu diperhatikan karena hal ini dapat berlanjut hingga dewasa serta menyebabkan terjadinya penyakit tidak menular. Salah satu penyebab kegemukan pada remaja karena asupan makanan yang berlebihan, kurangnya pengetahuan gizi dan kurangnya asupan serat yang bersumber utama dari buah dan sayuran. Pendidikan gizi merupakan langkah untuk menambah pengetahuan dan meningkatkan asupan serat. Penelitian ini bertujuan untuk meningkatkan pengetahuan serta meningkatkan asupan serat remaja. Metode yang digunakan adalah quasi eksperimen pada 84 siswa SMA. Penelitian dilaksanakan bulan Februari-Maret 2022 di empat SMA Surakarta. Penelitian ini menggunakan perlakuan pre-post test. Pengukuran pengetahuan responden menggunakaan Google form kuesioner dan formulir food record 3 x 24 jam. Analisa data menggunakan uji Wilcoxon dan uji Mann whitney. Hasil rata-rata tingkat pengetahuan responden pada kelompok kontrol sebelum diberikan penyuluhan dalam kategori baik sebanyak 11.9% Sesudah diberikan penyuluhan, terjadi peningkatan 40.5% p=0.002.Hasil rata-rata tingkat pengetahuan responden pada kelompok perlakuan sebelum diberikan perlakuan adalah kategori baik 14.3% dan sesudah diberikan perlakuan terjadi peningkatan sebanyak 71,4% dengan p=0.01. Hasil rata-rata asupan serat responden pada kelompok kontrol dan kelompok perlakuan sebelum dan sesudah intervensi adalah kategori kurang dengan persentase 100% yang artinya tidak terdapat perubahan pada masing-masing kelompok dengan p=0,142 (kelompok perlakuan) dan p=0,082 (kelompok kontrol). Dapat disimpulkan bahwa game tumpeng gizi seimbang berbasis web mampu meningkatkan pengetahuan gizi namun tidak merubah asupan serat responden.
NGHIÊN CỨU ĐẶC TÍNH DINH DƯỠNG CÁ HỒNG CHẤM ĐEN (Lutjanus russellii Bleeker, 1849) Ở CỬA SÔNG BA, TỈNH PHÚ YÊN
Authors: Ty Nguyễn Minh 
Published: October 2024

Cá hồng chấm đen (Lutjanus russellii Bleeker, 1849) thuộc họ Lutjanidae, bộ Perciformes. Đây là loài cá kinh tế, số lượng đang giảm sút. Mẫu cá nghiên cứu được thu từ tháng 02/2022 đến 12/2022 ở cửa sông Ba tỉnh Phú Yên. Nghiên cứu được thực hiện nhằm bổ sung cơ sở dẫn liệu về đặc điểm dinh dưỡng phục vụ cho việc ươm nuôi nhân tạo. Kết quả phân tích 265 mẫu cá cho thấy, cá hồng chấm đen là loài ăn tạp với hệ số tương quan chiều dài ruột và chiều dài chuẩn (RLG) là 1,248±0,312. Hệ số này tăng theo sự gia tăng trọng lượng cơ thể cá. Nhóm cá có trọng lượng 34-65 g hệ số này chỉ bằng 0,417±0,975, nhóm cá có trọng lượng 240,3-284,2 g hệ số này là 0,613±0,175 và tăng lên 1,248±0,312 ở nhóm cá có trọng lượng trên 1000 g. Tương quan giữa chiều dài và trọng lượng cá hồng chấm đen được thể hiện bởi phương trình W = 26357.10-6L3.3332. Thành phần thức ăn trong ống tiêu hóa của cá hồng chấm đen trưởng thành gồm có 6 loại thức ăn là giáp xác, cá, giun, thân mềm, mùn hữu cơ và tảo. Trong đó, giáp xác là thức ăn chủ yếu chiếm tỷ lệ cao nhất trong phổ thức ăn của cá là 65,8%.
ДВУСТВОРЧАТЫЙ СУБМЕНТАЛЬНЫЙ ЛОСКУТ ПРИ РЕКОНСТРУКЦИИ ПОЛНОСЛОЙНЫХ ДЕФЕКТОВ ЧЕЛЮСТНО-ЛИЦЕВОЙ ОБЛАСТИ ПОСЛЕ РАДИКАЛЬНОГО УДАЛЕНИЯ ОПУХОЛЕЙ. КЛИНИЧЕСКИЙ СЛУЧАЙ
Authors: К.Н. Амиралиев 
Published: October 2024

Реконструкция полнослойных дефектов челюстно-лицевой области является сложной задачей, поскольку предусматривает формирование внутренней и наружной выстилок дефекта. Для этого необходимы или два разных лоскута или двустворчатый регионарный или свободный лоскут. При использовании свободных трансплантатов пациенты могут не переносить длительную операцию из-за преклонного возраста или сопутствующих заболеваний. В статье приведены результаты применения двустворчатого субментального лоскута для восстановления, как кожи, так и слизистой оболочки дефекта. Операция проста, а время ее намного короче, чем при восстановлении свободным трансплантатом. Такое модифицированное использование субментального лоскута упрощает реконструкции сложного оро-лицевого дефекта.
Reconstruction of full-layer defects of the maxillofacial region is a difficult task, since it involves the formation of internal and external lining of the defect. This requires either two different flaps or a double layered regional flap or a free graft. When using free grafts, patients may not be able to tolerate a long-term operation due to old age or concomitant diseases. The article presents the results of using of bipaddled submental flap to restore both the skin and the mucous membrane of the defect. The operation is simple, and its time is much shorter than free flap reconstruction. This modified use of the submental flap simplifies the reconstruction of a complex oro-facial defect.
Жақ-бет аймағының толық қабатты ақауларын қайта құру қиын міндет болып табылады, өйткені ол ақаудың ішкі және сыртқы қабаттарын қалыптастыруды қарастырады. Ол үшін екі түрлі жамылғы немесе бивалды аймақтық немесе бос жамылғы қажет. Еркін трансплантаттарды пайдаланған кезде науқастарегде жасына немесе қатар жүретін ауруларға байланысты ұзақ операцияға шыдай алмайды. Мақалада ақаудың терісін де, шырышты қабығын да қалпына келтіру үшін бивалды субменталды жамылғыны қолдану нәтижелері келтірілген. Операция қарапайым және оның уақыты бос қолмен қалпына келтіруге қарағанда әлдеқайда қысқа. Субменталды жамылғыныңмұндай модификацияланған қолданылуы күрделі бет ақауларын қалпына келтіруді жеңілдетеді.
MODERN AVAR LEXICOGRAPHY: PROBLEMS AND PROSPECTS OF DEVELOPMENT
Authors: М.И. Магомедов 
Published: October 2024

История исследования лексической системы аварского языка имеет давние традиции. С точки зрения хронологии и системности исследования можно выделить два этапа: советский и дореволюционный. В дореволюционном периоде выделяется имена П. Палласа, А. Шифнера, И. Гюльденштедта, Р. Эркерта, П. Услара и А. Дирра. Впервые научное описание грамматики аварского языка со словарем и образцами устного народного творчества дал выдающийся кавказовед П.К. Услар. В XX веке грамматику аварского языка с приложением словаря издал Л.И. Жирков.
The history of the study of the lexical system of the Avar language has a long tradition. From the point of view of chronology and consistency of the study, two stages can be distinguished: Soviet and pre-revolutionary. In the pre-revolutionary period, the names of P. Pallas, A. Shifner, I. Guldenstedt, R. Erkert, P. Uslar and A. Dirr are distinguished. For the first time, a scientific description of the grammar of the Avar language with a dictionary and samples of oral folk art was given by the outstanding Kavkazologist P.K. Uslar. In the XX century, the grammar of the Avar language with the application of the dictionary was published by L.I. Zhirkov.
Спектр активности антибактериальных препаратов к золотистому стафилококку в среде военнослужащих
Authors: Е.И. Кременецкий , И.Г. Барцевич , М.Н. Ходосовский , С.П. Белега , Т.И. Прокопик 
Published: October 2024

В статье представлены результаты исследования активности антибактериальных препаратов к золотистому стафилококку в среде военнослужащих (n=46), находившихся на лечении в ГУ «432 ГВКМЦ» г. Минска с раневой поверхностью, у которых был обнаружен золотистый стафилококк. Изучены данные бактериологического исследования: наличие β-лактамазы, чувствительность, избирательная чувствительность и резистентность Staphylococcus aureus к антибактериальным лекарственным препаратам. Установлена связь между чувствительностью биологического материала у пациентов и положительной реакцией на β-лактамазу, разработана шкала и дана оценка уровня чувствительности и резистентности Staphylococcus aureus к 18 антибиотикам.
The article presents the results of the activity of antibacterial drugs against staphylococcus aureus among military personnel (n=46) who were treated at the State Institution "432 MMCMC" in Minsk with a wound surface, in whom staphylococcus aureus was detected. The data of bacteriological research were studied: the presence of β-lactamase, sensitivity, selective sensitivity and resistance of Staphylococcus aureus to antibacterial drugs. A relationship was established between the sensitivity of biological material in patients and a positive reaction to β-lactamase, a scale was developed and the level of sensitivity and resistance of Staphylococcus aureus to 18 antibiotics was assessed.
DESPESAS GERADAS POR GARGALO DURANTE RETENÇÃO AUTOMÁTICA DE IMPOSTO NO LANÇAMENTO DE NOTA FISCAL: ESTUDO DE CASO, REALIZADO NO PERÍODO DE 2021 A 2023 EM UMA EMPRESA SITUADA EM AMPÉRE, SUDOESTE DO PARANÁ
Authors: Siqueira Diorgines Oliveira de , Heberle Hélen Patricia Lamin , Hahn Keitilanger Grisa , Filho Luiz Alves Feitosa 
Published: October 2024

O estudo elenca os principais obstáculos que afetam o lançamento de notas fiscais, e causam atraso nos pagamentos das duplicatas de fornecedores contribuintes de impostos, e o recolhimento deles pelo tomador do serviço, a nível de mudar o faturamento da empresa. O estudo traz como tema, despesas geradas por gargalo durante retenção automática de imposto no lançamento de nota fiscal, estudo realizado na empresa Krindges Industrial S/A situada no sudoeste do Paraná. E como pergunta norteadora, indagou se os atrasos no lançamento de notas fiscais em tempo hábil, impactam nos resultados financeiros e geram atrasos nas retenções e envio dos impostos a Receita Federal? Para que houvesse coerência e desenvolvimento de uma forma ordenada, o estudo baseou-se em um objetivos geral que foi verificar se os atrasos em lançamento de notas fiscais em tempo hábil, impactam nos resultados financeiros e geram retenção de impostos na empresa, e para seguir uma linha de raciocínio utilizou-se de três objetivos específicos, levantamento bibliográficos em relação ao tema do estudo, conhecer o sistema contábil e de lançamento in loco, levantamento de dados e tabulação e analise de resultados. E como metodologia, pode-se dizer que se trata de um estudo de caso, bibliográfico e quantitativo. A estudo demonstrou que atrasos no lançamento de notas fiscais causaram prejuízo financeiro à empresa, totalizando R$ 7.350,09 entre 2021 e 2023. Esses custos foram atribuídos principalmente a juros por pagamentos em atraso e ao trabalho extra do setor contábil e TI para corrigir as falhas. Embora a apresentação pareça pequena para uma empresa SA de lucro real, este valor poderia ter sido direcionado para investimentos estratégicos, gerando um retorno financeiro maior ou melhorando a produção.
Academic Staff Perceptions on Graduate Students’ Attitudes towards Academic Writing and Research in Selected Public Universities in Uganda
Authors: Kalule John , Ssali Kizza Francis , Edward Masembe , Ssebowa Dorothy Kyagaba 
Published: October 2024

The study aimed to find out academic staff perceptions of graduate students’ attitudes towards academic writing and research skills in selected Public Universities in Uganda. It employed a phenomenological design and a qualitative approach. Graduate students, academic staff, and academic administrative staff as the study population. Study participants depended on the saturation of the findings collected. These participants were selected using a purposive sampling technique. Data from academic administrative staff and academic staff were collected using an interview guide. A focus group discussion guide for graduate students was the second data collection tool. Data were analysed using the thematic data analysis technique. Results showed that academic staff perceptions of graduate students’ attitudes on academic writing and research skills were negative. Negative perceptions were recorded on the generation of research ideas, enthusiasm, text structure, formal academic language, paraphrasing, plagiarism, and making citations. The study concluded that the perceptions of academic staff on graduate students’ attitudes towards academic writing and research were generally negative on the generation of research ideas, enthusiasm, use of formal academic research language, paraphrasing, plagiarism, and making citations. Thus, it was recommended that supervisors/mentors should be retooled in active research-based instructional supervision where they can be encouraged to work in groups, and initiate professional activities, such as mentoring and coaching, to assist them in supervising and evaluating graduate students’ research projects
PENGARUH MEDIA PEMBELAJARAN KARTU SUKU KATA TERHADAP KETERAMPILAN MEMBACA PERMULAAN DI SDN BRANTA PASESER 3 KABUPATEN PAMEKASAN
Authors: Lidia Maulidia Nifa , Pratikno Ahmad Sudi 
Published: October 2024

Abstrak
Membaca merupakan salah satu jenis kemampuan berbahasa tulis yang bersifat reseptif. Disebut reseptif karena dengan membaca seseorang akan memperoleh informasi, ilmu pengetahuan, dan pengalaman-pengalaman baru. Semua yang diperoleh melalui bacaan itu akan memungkinkan orang tersebut mampu mempertinggi daya pikirannya, mempertajam pandangannya, dan memperluas wawasannya. Dalam penelitian ini saya menggunakan media pembelajaran berupa kartu suku kata yang merupakan strategi paling efektif untuk meningkatkan kemampuan membaca permulaan pada siswa Kartu suku kata adalah alat yang terdiri dari huruf-huruf yang disusun menjadi suku kata, yang dapat membantu siswa dalam memahami struktur kata dan meningkatkan kemampuan membaca dengan lebih baik. Dalam penelitian ini, kami akan menjelaskan bagaimana kartu suku kata dapat membantu siswa dalam meningkatkan kemampuan membaca, serta bagaimana strategi ini dapat diterapkan dalam proses pembelajaran
Kata Kunci: Membaca permulaan, media kartu suku kata
Будущее образования — в образовании для будущего
Authors: Юрий Саямов 
Published: October 2024

Рассматривается новая глобальная инициатива ЮНЕСКО «Будущее образования», которая предлагает перспективную образовательную концепцию на период до 2050 года и за его пределы. Инициатива включила в себя разработку и утверждение международного доклада, получившего название «Будущее образования. Учиться становиться». Отмечается важность регенеративного образования, экологического образования и образования для устойчивого развития. В связи с этим упоминаются итоги Всемирной конференции ЮНЕСКО по образованию для устойчивого развития 17–19 мая 2021 года в Берлине.
The article examines the new UNESCO global initiative "The Future of Education", which offers a promising educational concept for the period up to 2050 and beyond. The initiative involved the development and approval of an international report, called "The Futures of education. Learning to become". The importance of regenerative education, environmental education and education for sustainable development is noted. In this regard, the results of the UNESCO World Conference on Education for Sustainable Development on 17–19 May 2021 in Berlin are mentioned.
Культурная память: семейный аспект
Authors: (Родионова) Ольга Джафарова 
Published: October 2024

Коммеморативные исследования – один из актуальных трендов современной гуманитарной науки. Институты памяти в разных аспектах определяют не только наш взгляд на прошлое, но и на современность. Уровень семьи, повседневности традиционно при своей максимальной доступности наименее изучен. Статья посвящена 350-летней истории крестьянского рода: ее перемещениям, сохранению родовой идентичности, преодолению вызовов истории ХХ века.
Commemorative studies are one of the current trends in modern humanities. Memory institutions in various aspects determine our view both of the past and present. The family level, everyday life, traditionally, with its maximum accessibility, is the least studied. The article examines the 350-year history of the peasant clan: its movements, the preservation of clan identity, and overcoming the challenges of the history of the 21st century.
Нивхский обрядовый праздник обновления природы «Чир ань» («Питул»)
Authors: Ольга Хурьюн 
Published: October 2024

На территории Сахалинской области (с. Чир-Унвд МО «Тымовский городской округ» и п. Ноглики МО «Городской округ Ногликский») был возрожден нивхский обрядовый праздник обновления природы «Питул», целью которого стало сохранение духовной культуры коренных малочисленных народов островного региона.
On the territory of Sakhalin Oblast (Chir-Unvd village of the Tymovsk Municipal District and Nogliki settlement of the Nogliki Municipal District), the Nivkh ritual feast of nature renewal “Pitul” was revived to preserve the spiritual culture of the indigenous minorities of the island region.