bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mechanistic Insights into the Protective Roles of Polyphosphate Against Amyloid Cytotoxicity
Authors: Lempart Justine , Tse Eric , Lauer James A. , Ivanova Magdalena I , Sutter Alexandra , Yoo Nicholas , Huettemann Philipp , Southworth Daniel , Jakob Ursula 
Published: July 2019

ABSTRACTThe universally abundant polyphosphate (polyP) accelerates fibril formation of disease-related amyloids and protects against amyloid cytotoxicity. To gain insights into the mechanism(s) by which polyP exerts these effects, we focused on α-synuclein, a well-studied amyloid protein, which constitutes the major component of Lewy bodies found in Parkinson’s Disease. Here we demonstrate that polyP is unable to accelerate the rate-limiting step of α-synuclein fibril formation but effectively nucleates fibril assembly once α-synuclein oligomers are formed. Binding of polyP to α-synuclein either during fibril formation or upon fibril maturation substantially alters fibril morphology, and effectively reduces the ability of α-synuclein fibrils to interact with cell membranes. The effect of polyP appears to be α-synuclein fibril specific, and successfully prevents the uptake of fibrils into neuronal cells. These results suggest that altering the polyP levels in the extracellular space might be a potential therapeutic strategy to prevent the spreading of the disease.
7-(Biphenyl-4-yl)-6-hydroxyindan-1-one
Authors: McCoy Ryan N. , Robertson Katherine N. , Ylijoki Kai E. O. 
Published: July 2019

The title compound, C21H16O2, was isolated from the reaction of 1-(2-methoxyethoxy)-1-vinylcyclopropane, 4-ethynylbiphenyl, and CO in a [5 + 1 + 2 + 1] cycloaddition reaction catalysed by [Rh(CO)2Cl]2. The crystals precipitated directly from the crude reaction mixture. A hydrogen-bonding framework between the hydroxy and carbonyl groups of a symmetry-related neighbour connects the molecules into chains running parallel to the crystallographic c axis. A minor non-merohedral twin component was included in the refinement.
Knock combustion investigation on a two-stroke spark ignition UAV engine burning RP-3 kerosene fuel
Authors: Liu Rui , Sheng Jing , Ma Jie , Yang Guang , Dong Xuefei , Liang Yongsheng 
Published: July 2019

Purpose
The purpose of this paper is to investigate the knock combustion characteristics, including the combustion pressure, heat release rate (HRR) and knock intensity of aviation kerosene fuel, that is, Rocket Propellant 3 (RP-3), on a port-injected two-stoke spark ignition (SI) engine.

Design/methodology/approach
Experimental investigation using a bench test and the statistical analysis of data to reflect the knock combustion characteristics of the two-stroke SI unmanned aerial vehicle (UAV) engine on RP-3 kerosene fuel.

Findings
Under the full load condition of 4,000 rpm, at the ignition timing of 25 degree of crank angle (°CA) before top dead centre (BTDC), the knock combustion is sensitive to the thinner mixture; therefore, the knock begins to occur when the excess air ratio is larger than 1.0. When the excess air ratio is set as 1.2, the knock obviously appears with the highest knock intensity. At the excess air ratio of 1.2, better engine performance is obtained at the ignition timing range of 20-30 °CA BTDC. However, the ignition timing at 30° CA BTDC significantly increases the peak combustion pressure and knock intensity with the advancing heat release process.

Practical implications
Gasoline has a low flash point, a high-saturated vapour pressure and relatively high volatility, and it is a potential hazard near a naked flame at room temperature, which can create significant security risks for its storage, transport and use. The authors adopt a low-volatility single RP-3 kerosene fuel for all vehicles and equipment to minimise the number of different devices using various fuels and improve the military application safety.

Originality/value
Most two-stroke SI UAV engines for military applications burn gasoline. A kerosene-based fuel for stable engine operation can be achieved because the knock combustion can be effectively suppressed through the combined adjustment of the fuel amount and spark timing.
Control of bearingless electric machines dedicated for aviation
Authors: Żokowski Mariusz , Falkowski Krzysztof , Kurnyta-Mazurek Paulina , Henzel Maciej 
Published: July 2019

Purpose
The paper presents the results of work on control systems of bearingless electric motors. Authors proposed the applications of bearingless electric machines for aircraft actuation system. Suggested solution characterizes novel concept of on-board equipment design such as More Electric Aircraft. Magnetic suspension technology allows elimination of friction force and the negative performance features of classic bearing system. However, to achieve all these purposes appropriately, dedicated control system must be also applied.

Design/methodology/approach
The development of a control system of bearingless electric machine is presented in detail. Mathematical model and construction of induction bearingless motor are widely discussed. Then, proportional–integral-derivative controller algorithm designing for BEM control system was presented using the well pole placement method. Simulation model of BEM control system with use of Matlab-Simulink software was shown. Finally, experimental studies on laboratory stand were introduced. The paper presents design methodology of conventional and advanced control system of bearingless motor.

Findings
The presented concept of the bearingless electric machines could be applied in the on-board actuation system. During research, full control system of bearingless electric motor was designed and tested. This system consisted of two subsystems. The first responded for rotary speed stabilization and second one was designed for position control of the rotor in the air gap.

Practical implications
The presented concept of the bearingless electric machines could be applied in the on-board actuation system. During research, full control system of bearingless electric motor was designed and tested. This system consisted of two subsystems. The first responded for rotary speed stabilization and second one was designed for position control of the rotor in the air gap.

Originality/value
The idea of active magnetic suspension system will be implemented for aviation on technology readiness level V. The paper presents unique laboratory stand with bearingless electric motor and experimental studies. The stable time responses of designed control system were presented and discussed. In addition, preliminary considerations of advanced control system with robust controller were introduced as well.
Fitting procedure based on Differential Evolution to evaluate impedance parameters of metal–coating systems
Authors: González Francisco , Greiner David , Mena Vicente , Souto Ricardo M. , Santana Juan J. , Aznárez Juan J. 
Published: July 2019

PurposeImpedance data obtained by electrochemical impedance spectroscopy (EIS) are fitted to a relevant electrical equivalent circuit to evaluate parameters directly related to the resistance and the durability of metal–coating systems. The purpose of this study is to present a novel and more efficient computational strategy for the modelling ofEISmeasurements using the Differential Evolution paradigm.Design/methodology/approachAn alternative method to non-linear regression algorithms for the analysis of measured data in terms of equivalent circuit parameters is provided by evolutionary algorithms, particularly the Differential Evolution (DE) algorithms (standardDEand a representative of the self-adaptiveDEparadigm were used).FindingsThe results obtained withDEalgorithms were compared with those yielding from commercial fitting software, achieving a more accurate solution, and a better parameter identification, in all the cases treated. Further, an enhanced fitting power for the modelling of metal–coating systems was obtained.Originality/valueThe great potential of the developed tool has been demonstrated in the analysis of the evolution ofEISspectra due to progressive degradation of metal–coating systems. Open codes of the different differential algorithms used are included, and also, examples tackled in the document are open. It allows the complete use, or improvement, of the developed tool by researchers.
“Welcome to Holland!” People with Down syndrome as vulnerable consumers
Authors: Dias de Faria Marina , Moreira Casotti Leticia 
Published: July 2019

Purpose
Consumers with Down syndrome are present in all countries, but there has been little marketing research examining their consumption experiences. The purpose of this exploratory investigation is the analysis of the consumption meanings and practices of Down syndrome adults from their own point of view and from their families’ perspectives.

Design/methodology/approach
Data was drawn from 44 narratives interviews that included families'stories, description of album photos and projective techniques.

Findings
The research shows from the families’ perspectives how barriers to consumption prevent Down syndrome adults from becoming agentic consumers. The findings reveal the “labels” associated with the vulnerability of people with Down syndrome and their families in their market experiences.

Research limitations/implications
Research is limited to a single country and location and is focused on a specific group of overlooked consumers. We encourage the expansion of the research to a wider group and different locations.

Practical implications
The research identifies barriers to social inclusion that can support public policy and marketing manangement that contribute to a more humanistic marketing.

Originality/value
The research presents narratives of adults with Down syndrome, their mothers and siblings. The findings contribute to a comprehension about the welfare of this traditionally neglected, vulnerable group of consumers, which is useful for consumers, Down syndrome people and their families, marketing managers and public policymakers.
Employee voice, engagement and organizational effectiveness: a mediated model
Authors: Jha Nivedita , Potnuru Rama Krishna Gupta , Sareen Puja , Shaju Sharon 
Published: July 2019

PurposeThis study is based on social exchange theory and aims at understanding the role of employee engagement as a mediator between employee voice and organizational effectiveness.Design/methodology/approachData was collected to test the mediating role of employee engagement between employee voice and organizational effectiveness. The respondents were employees in different IT companies located in major cities in India. The model was tested for full and partial mediation of employee engagement using structural equation modeling.FindingsConsidering the self-reported survey from 232 employees from companies in the IT sector, the findings reveal that there exists a significant association between employee voice and organizational effectiveness. The results reflect a close association between employee engagement and organizational effectiveness too. However, no significant association was found between employee voice and organizational effectiveness. Employee engagement is found to mediate the relationship between employee voice and organizational effectiveness.Research limitations/implicationsThe foremost limitation of the study is the sample group that is limited to employees working in IT companies in Bangalore city. The results cannot be generalized to the entire IT industry in India. Although attempts are made to eliminate common method bias, there are chances of an overstated relationship by common method variance that cannot be neglected completely.Practical implicationsThe paper will provide a deep insight to the practitioners about the role of employee voice in the engagement of employees. It will also indicate to the managers how the effectiveness of an organization can be heightened by creating opportunities for employees to voice their opinion in the organization.Originality/valueThe present study indicated that though there is an association between the independent variable, employee voice, and the dependent variable, organizational effectiveness, the relationship becomes more significant in the presence of employee engagement between them.
Knowledge payment research: status quo and key issues
Authors: Qi Tuotuo , Wang Tianmei , Ma Yanlin , Zhou Xinxue 
Published: July 2019

PurposeKnowledge sharing has entered the stage of knowledge payment with the typical models of paid Q&A, live session, paid subscription, course column and community service. Numerous knowledge suppliers have begun to pour into the knowledge payment market, and users' willingness to pay for premium content has increased. However, the academic research on knowledge payment has just begun.Design/methodology/approachIn this paper, the authors searched several bibliographic databases using keywords such as “knowledge payment”, “paid Q&A”, “pay for answer”, “social Q&A”, “paywall” and “online health consultation” and selected papers from aspects of research scenes, research topics, etc. Finally, a total of 116 articles were identified for combing studies.FindingsThis study found that in the early research, scholars paid attention to the definition of knowledge payment concept and the discrimination of typical models. With the continuous enrichment of research literature, the research direction has gradually been refined into three main branches from the perspective of research objects, i.e. knowledge provider, knowledge demander and knowledge payment platform.Originality/valueThis paper focuses on discussing and sorting out the key research issues from these three research genres. Finally, the authors found out conflicting and contradictory research results and research gaps in the existing research and then put forward the urgent research topics.
School-to-work transition and vocational education: a comparison across Europe
Authors: Brunetti Irene , Corsini Lorenzo 
Published: July 2019

Purpose
Youth unemployment is one of the major problems that the economic systems face. Given this issue, the purpose of this paper is to assess whether school-to-work transition is easier for individuals with secondary vocational education compared to general secondary education. The authors want to explore which vocational systems across Europe produce better effects.

Design/methodology/approach
The authors use data from a module on “Entry of young people into the labour market” from the 2009 and 2014 European Labour Survey and they estimate multinomial probit models, allowing for violation of the irrelevance of the alternative assumption.

Findings
The authors find that in countries with the dual vocational system, vocational education improves employability both in the short and medium run, whereas in countries with a school-based vocational system, results are mixed and, only in some cases, the effect of vocational studies is significantly positive.

Research limitations/implications
Sample size for short-run analysis is a bit small in a few countries (Austria and Germany). Moreover, even if the authors have reason to believe that the methods adopted are mitigating the omitted heterogeneity issues and robustness checks are run on these aspects, these issues cannot be fully excluded.

Practical implications
The authors provide policy implications, showing that dual vocational systems can improve school-to-work transitions and that vocational structure is particularly effective in this case.

Social implications
The authors provide information on which education model may offer better chance in terms of labour outcomes.

Originality/value
Given the relevance of youth unemployment, the authors provide valuable information on how to mitigate this problem. The use of cross-country comparisons offers great insights on which vocational systems appear to be well-suited to enhance employability.
Personnel policy adjustments when apprentice positions are unfilled
Authors: Hinz Tina 
Published: July 2019

PurposeGerman establishments face increasing difficulties in filling their apprentice positions. Thus, firms are less able to train (and later retain) their own skilled workforce. The purpose of this paper is to analyse the firms’ personnel policy adjustments in response to unfilled apprentice positions.Design/methodology/approachTo estimate the within-firm personnel policy adjustments when unfilled apprentice positions arise, fixed effects panel estimations are applied to a large German establishment-level data set, the IAB Establishment Panel (2008–2016).FindingsThe estimates indicate that some firms post slightly more apprentice positions in the period after facing unfilled apprentice positions. Moreover, the results reveal that affected craft establishments in urban regions retain more apprenticeship graduates. Besides of these findings, there are no indications of emphasised personnel policy adjustments.Practical implicationsThe multivariate results do not support the claim that training firms may abstain from apprenticeship training when facing unfilled apprentice positions.Originality/valueThe study shows first evidence of firms’ personnel policy adjustments when apprentice positions remain vacant in Germany, a country with a traditionally high relevance of apprenticeship training.
Beyond retirement: who stays at work after the standard age of retirement?
Authors: Anxo Dominique , Ericson Thomas , Herbert Anna 
Published: July 2019

Purpose
Drawing on a unique combination of longitudinal administrative data and a postal survey, the purpose of this paper is to identify the socio-economic factors and individual characteristics that affect senior citizens’ decision to continue working on the Swedish labour market after the standard retirement age.

Design/methodology/approach
By using standard econometric techniques (multinomial logit model) on a large representative sample of 20,000 senior citizens residing in Sweden, the auhtors analyse the extent to which socio-economic factors and individual characteristics including personality traits affect the decision of senior citizens to delay retirement and to continue working after the standard retirement age.

Findings
The results of our estimations show clearly that good health, high educational attainment/high-skilled jobs, good psychosocial work environment, employment status (to be self-employed), personality traits (extraversion, openness to experience and conscientiousness) as well as industrial sectors (agriculture, healthcare and transport) are strong predictors of the continuation of work after the standard retirement age (65 years old).

Research limitations/implications
High job quality and good working conditions, along with continuous improvements in public health, are seemingly essential elements for motivating senior workers to delay retirement as are preventive policy measures favouring the development of decent and sustainable working conditions across the life course.

Originality/value
To the best of the authors’ knowledge, the paper is the first attempt in Sweden to analyse jointly a large range of factors influencing the decision to remain in the labour force after the standard/normal pension age, including psychosocial working conditions and personality traits.
Balance rather than critical mass or tokenism
Authors: Lafuente Esteban , Vaillant Yancy 
Published: July 2019

Purpose
The purpose of this paper is to analyzes how board’s gender diversity, and more specifically a gender-balanced configuration – i.e. a proportion of women in the boardroom ranging between 40 and 60 percent – affects economic and risk-oriented performance in financial firms.

Design/methodology/approach
The empirical application uses a rich data set that includes detailed accounting and organizational information for all financial firms in the Costa Rican industry during the period 2000–2012. The proposed hypotheses are tested using panel data (fixed-effects) regression models that emphasize that bank performance is affected by various dimensions of the banks’ gender diversity.

Findings
The longitudinal analysis of the Costa Rican banking industry reveals that, unlike a proportion indicating a particular critical mass of women on the board, a balanced gender configuration yields superior economic performance (ROA and net intermediation margin). Additionally, the findings show that the performance benefits of gender diversity only exists in the presence of a gender-balanced board configuration, and that this positive effect is not conditioned by the presence of women leadership in the corporate hierarchy (Chair or CEO).

Originality/value
The paper further explores the influence of board gender diversity on organizational performance by adopting an approach to the gender diversity–performance relationship that goes beyond the mere representation of women within the corporate hierarchy.
Parameter optimization of sealing performance for packer rubber
Authors: Zhang Fuying , Shui Hao Che , Zhang Yufei 
Published: July 2019

Purpose
The purpose of this paper is based on the response surface method, the authors determined the conditions for achieving the optimum rubber-sealing performance by using the maximum contact stress as the response value.

Design/methodology/approach
A two-dimensional model of a compression packer rubber was established by finite-element analysis software. Under the single axial load of 53.85 MPa, the four single factors of the end-face inclination angle, subthickness, height of rubber and friction coefficient of the rubber were analyzed.

Findings
Results show that the optimum sealing performance of the rubber tube is achieved when the end-face angle is equal to 45º and the thickness of the rubber tube is 9 mm. The response surface designed by Box–Behnken shows that the sealing performance of the rubber tube is the optimum when the end-face inclination angle is 48.1818°, the subthickness is 9 mm, the height of rubber is 90 mm and the friction coefficient is 0.1. Verification test results show that the model is reliable and effective.

Originality/value
Packer operations are performed downhole, and research on real experiments is limited. In this work, the feasibility of such experiments is determined by comparing finite-element modeling with actual experiments, and the results have guiding significance for actual downhole operations.