bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bangladesh accountants and Continuing Professional Development
Authors: Halabi Abdel Karim , Chowdhury Mohammad Salahuddin 
Published: November 2018

Purpose
The purpose of this paper is to examine professional accountant’s views on their satisfaction with Continuing Professional Development (CPD) offered by members of the Institute of Chartered Accountants of Bangladesh (ICAB). While there is a great deal of research on CPD and accountants in developed countries, less developing countries are absent from this literature, and there have been calls for this type of research.

Design/methodology/approach
The present study employed a survey of members of the ICAB.

Findings
Results show that accountants in Bangladesh are satisfied with the CPD provided by their profession, and when satisfaction is compared with more developed countries, Bangladesh is greater on a number of measures. ICAB members would like to also be provided with opportunities to undertake CPD in more ways than just face to face.

Practical implications
The study has important implications not only for accountants from emerging economies such as Bangladesh, but also for the International Federation of Accountants and other less developed countries (LDCs). The results advance the understanding of professional accounting bodies from an international perspective.

Originality/value
This is the first study of CPD and accounting professionals in LDCs. The information obtained can inform the development and practice of other professional accounting bodies in emerging economies.
The alternative sigma factor SigF is a key player in the control of secretion mechanisms in Synechocystis sp. PCC 6803
Authors: Flores Carlos , Santos Marina , Pereira Sara B. , Mota Rita , Rossi Federico , De Philippis Roberto , Couto Narciso , Karunakaran Esther , Wright Phillip C. , Oliveira Paulo , Tamagnini Paula 
Published: November 2018

SummaryCyanobacterial alternative sigma factors are crucial players in environmental adaptation processes, which may involve bacterial responses related to maintenance of cell envelope and control of secretion pathways. Here, we show that the Group 3 alternative sigma factor F (SigF) plays a pleiotropic role in Synechocystis sp. PCC 6803 physiology, with a major impact on growth and secretion mechanisms, such as the production of extracellular polysaccharides, vesiculation and protein secretion. Although ΔsigF growth was significantly impaired, the production of released polysaccharides (RPS) increased threefold to fourfold compared with the wild‐type. ΔsigF exhibits also impairment in formation of outer‐membrane vesicles (OMVs) and pili, as well as several other cell envelope alterations. Similarly, the exoproteome composition of ΔsigF differs from the wild‐type both in amount and type of proteins identified. Quantitative proteomics (iTRAQ) and an in silico analysis of SigF binding motifs revealed possible targets/pathways under SigF control. Besides changes in protein levels involved in secretion mechanisms, our results indicated that photosynthesis, central carbon metabolism and protein folding/degradation mechanisms are altered in ΔsigF. Overall, this work provided new evidences about the role of SigF on Synechocystis physiology and associates this regulatory element with classical and non‐classical secretion pathways.
Multilingual matrix: exploring the process of language switching by family therapists working with multilingual families
Authors: Das Sreety 
Published: November 2018

This article explores the phenomenon of language switching in clinical practice in the systemic psychotherapy field. I consider multilingual therapists’ experiences of switching from use of one language to another in the therapeutic context, the therapists’ awareness of this, and the intentions or possible meanings they attribute to these experiences. The interpretative phenomenological approach was used to analyse the experiences of four female family therapists based in London and from a range of cultures and communities.It was found that the therapists construed their multilingual position as both challenging and advantageous. Suggestions are made to explore the language switching phenomenon in supervision and training, as well as to think more widely with monolingual and multilingual colleagues and supervisors about the meaning and the use of language switching in therapeutic practice. Existing research in this area can be developed further to provide a framework that could benefit practitioners in the systemic field.Practitioner pointsLanguage switching was viewed as an invaluable skill by therapists, enabling them to shift between languages and understand their clients’ world in a rich wayMultilingual family therapists can address issues of power and voice with families through the practice of language switching
Mammography facilities serving vulnerable women have longer follow‐up times
Authors: Karliner Leah S. , Kaplan Celia , Livaudais‐Toman Jennifer , Kerlikowske Karla 
Published: November 2018

ObjectiveTo investigate mammography facilities’ follow‐up times, population vulnerability, system‐based processes, and association with cancer stage at diagnosis.Data SourcesProspectively collected from San Francisco Mammography Registry (SFMR) 2005‐2011, California Cancer Registry 2005‐2012, SFMR facility survey 2012.Study DesignWe examined time to biopsy for 17 750 abnormal mammogram results (BI‐RADS 4/5), categorizing eight facilities as short or long follow‐up based on proportion of mammograms with biopsy at 30 days. We examined facility population vulnerability (race/ethnicity, language, education), and system processes. Among women with a cancer diagnosis, we modeled odds of advanced‐stage (≥IIb) cancer diagnosis by facility follow‐up group.Data Extraction MethodsMerged SFMR, Cancer Registry and facility survey data.Principal FindingsFacilities (N = 4) with short follow‐up completed biopsies by 30 days for 82% of mammograms compared with 62% for facilities with long follow‐up (N = 4) (P < 0.0001). All facilities serving high proportions of vulnerable women were long follow‐up facilities. The long follow‐up facilities had fewer radiologists, longer biopsy appointment wait times, and less communication directly with women. Having the index abnormal mammogram at a long follow‐up facility was associated with higher adjusted odds of advanced‐stage cancer (OR 1.45; 95% CI 1.10‐1.91).ConclusionsProviding mammography facilities serving vulnerable women with appropriate resources may decrease disparities in abnormal mammogram follow‐up and cancer diagnosis stage.
CRISPR/Cas‐based screening of a gene activation library in Saccharomyces cerevisiae identifies a crucial role of OLE1 in thermotolerance
Authors: Li Pengsong , Fu Xiaofen , Zhang Lei , Li Shizhong 
Published: November 2018

SummaryCRISPR/Cas‐based (clustered regularly interspaced short palindromic repeats/CRISPR‐associated) screening has been proved to be an efficient method to study functional genomics from yeast to human. In this study, we report the development of a focused CRISPR/Cas‐based gene activation library in Saccharomyces cerevisiae and its application in gene identification based on functional screening towards improved thermotolerance. The gene activation library was subjected to screening at 42°C, and the same library cultured at 30°C was set as a control group. After five successive subcultures, five clones were randomly picked from the libraries cultured at 30 and 42°C, respectively. The five clones selected at 30°C contain the specificity sequences of five different single guide RNAs, whereas all the five clones selected at 42°C contain the specificity sequence of one sgRNA that targets the promoter region of OLE1. A crucial role of OLE1 in thermotolerance was identified: the overexpression of OLE1 increased fatty acid unsaturation, and thereby helped counter lipid peroxidation caused by heat stress, rendering the yeast thermotolerant. This study described the application of CRISPR/Cas‐based gene activation screening with an example of thermotolerant yeast screening, demonstrating that this method can be used to identify functional genes in yeast.
Assessing and Prioritizing Barriers to Aquatic Connectivity in the Eastern United States
Authors: Martin Erik H. 
Published: November 2018

AbstractThere are tens of thousands of dams and millions of road‐stream crossings in the eastern United States (U.S.) which can prevent fish and other aquatic organisms from accessing key habitats. There is growing momentum in the eastern U.S., and throughout the country, to remove dams which no longer serve their intended purpose, provide improved fish passage facilities at those dams that cannot feasibly be removed, and upgrade road‐stream crossings to benefit aquatic organism passage (AOP). However, these projects are expensive and given the extensive scope of the problem and the limited resources available to address it, it is imperative to be strategic in deciding which barriers are removed or upgraded. The Nature Conservancy, in conjunction with several partners, has conducted a suite of analyses which assess and prioritize barriers to AOP for the potential ecological gains that could be realized if they were removed or upgraded. The results of these analyses have been used both proactively and reactively by managers throughout the eastern U.S. to identify potential connectivity restoration projects, support funding requests, and help inform funding allocation decisions by providing a common evaluation system for the many thousands of potential projects. In contrast to more prescriptive barrier removal optimizations, their flexibility of use provides managers with a practical framework for planning aquatic connectivity restoration while remaining open to the element of opportunity.
Towards a systematic understanding of differences between archaeal and bacterial diversity
Authors: Spang Anja , Offre Pierre 
Published: November 2018

SummaryIn this crystal ball, we discuss emerging methodologies that can help reaching a synthesis on the biodiversity of Archaea and Bacteria and thereby inform a central enigma in microbiology, i.e. the fundamental split between these primary domains of life and the apparent lower diversity of the Archaea.
Drinking Risk Level Reductions Associated with Improvements in Physical Health and Quality of Life Among Individuals with Alcohol Use Disorder
Authors: Witkiewitz Katie , Kranzler Henry R. , Hallgren Kevin A. , O'Malley Stephanie S. , Falk Daniel E. , Litten Raye Z. , Hasin Deborah S. , Mann Karl F. , Anton Raymond F. 
Published: November 2018

BackgroundAbstinence and no heavy drinking days are currently the only Food and Drug Administration–approved end points in clinical trials for alcohol use disorder (AUD). Many individuals who fail to meet these criteria may substantially reduce their drinking during treatment, and most individuals with AUD prefer drinking reduction goals. One‐ and two‐level reductions in World Health Organization (WHO) drinking risk levels have been proposed as alternative end points that reflect reduced drinking and are associated with reductions in drinking consequences, improvements in mental health, and reduced risk of developing alcohol dependence. The current study examined the association between WHO drinking risk level reductions and improvements in physical health and quality of life in a sample of individuals with alcohol dependence.MethodsSecondary data analysis of individuals with alcohol dependence (n = 1,142) enrolled in the longitudinal, prospective COMBINE study, a multi site randomized placebo‐controlled clinical trial, examining the association between reductions in WHO drinking risk levels and change in blood pressure, liver enzyme levels, and self‐reported quality of life following treatment for alcohol dependence.ResultsOne‐ and two‐level reductions in WHO drinking risk level during treatment were associated with significant reductions in systolic blood pressure (p < 0.001), improvements in liver enzyme levels (all p < 0.01), and significantly better quality of life (p < 0.001).ConclusionsOne‐ and two‐level reductions in WHO drinking risk levels predicted significant improvements in markers of physical health and quality of life, suggesting that the WHO drinking risk level reduction could be a meaningful surrogate marker of improvements in how a person “feels and functions” following treatment for alcohol dependence. The WHO drinking risk levels could be useful in medical practice for identifying drinking reduction targets that correspond with clinically significant improvements in health and quality of life.
Comparative use of active searches and artificial refuges to detect amphibians in terrestrial environments
Authors: Michael Damian R. , Blanchard Wade , Scheele Ben C. , Lindenmayer David B. 
Published: November 2018

AbstractArtificial refuges (cover boards) are commonly used to survey and monitor herpetofauna in many parts of the world. Despite the extensive use of artificial refuges in mesic environments, their effectiveness for detecting amphibians in temperate zones has rarely been examined. We compared amphibian detection probabilities between two survey methods; active searches of natural habitat and artificial refuges of three different types (corrugated steel, roofing tiles and timber railway sleepers). Our study area included five bioregions encompassing a 1180‐km latitudinal gradient across a modified, temperate eucalypt woodland vegetation community in south‐eastern Australia. We deployed 14 778 artificial refuges in terrestrial environments, within patches of remnant vegetation, and collected presence and abundance data on herpetofauna between 1999 and 2017. We used Bayesian logistic regression to identify the most effective survey method for detecting frog species across all bioregions. We modelled frog detections by fitting survey method, time since refuge deployment and rainfall prior to each survey. We detected 3970 individuals from 18 frog species. Overall, we found active searches and timber substrates most effective for detecting a broad range of species, although detection rates were driven by the numerically abundant spotted marsh frog Limnodynastes tasmaniensis. Timber refuges were effective for detecting several burrowing species, whereas active searches were effective at detecting habitat generalists. Quadratic effects of rainfall prior to survey as opposed to linear effects of time since artificial refuge placement was important in explaining frog detection rates in some bioregions. Active searches, timber railway sleepers and sheets of corrugated steel provide complimentary survey methods for detecting amphibians, although detection rates are influenced by rainfall patterns. Artificial refuges provide a time‐effective and standardized method for studying amphibians in their non‐breeding terrestrial environment and should be incorporated into future surveys and biodiversity monitoring programmes.
Efficacy of DPP‐4 inhibitors, GLP‐1 analogues, and SGLT2 inhibitors as add‐ons to metformin monotherapy in T2DM patients: a model‐based meta‐analysis
Authors: Inoue Hiroyuki , Tamaki Yoko , Kashihara Yushi , Muraki Shota , Kakara Makoto , Hirota Takeshi , Ieiri Ichiro 
Published: November 2018

AimsThe aim of the present study was to quantitate the hypoglycaemic effects of dipeptidyl peptidase‐4 inhibitors (DPP‐4i), glucagon‐like peptide‐1 receptor agonists (GLP‐1r) and sodium glucose cotransporter 2 inhibitors (SGLT2i) as add‐on treatments to metformin monotherapy in patients with type 2 diabetes mellitus (T2DM) using a model‐based meta‐analysis (MBMA).MethodsA systematic literature search of public databases was conducted to develop models that describe the time courses of the fasting plasma glucose (FPG)‐ and haemoglobin A1c (HbA1c)‐lowering effects of three antidiabetic classes using NONMEM 7.3.0.ResultsSeventy‐six publications were eligible for this study, and 873 FPG and 1086 HbA1c values were collected. We developed a physiological indirect response model that described the time courses of FPG and HbA1c and simulated reductions in these values 90 days after the initiation of add‐on treatments. FPG and HbA1c reductions with once weekly exenatide, liraglutide and dulaglutide were greater than those with other drugs. Mean changes from baseline FPG and HbA1c with these drugs were as follows: exenatide (−22.5 and −16.6%), liraglutide (−22.1 and −16.3%), and dulaglutide (−19.3 and −14.3%). The hypoglycaemic effects of DPP‐4i and SGLT2i were similar.ConclusionsOnce weekly exenatide, liraglutide and dulaglutide provided better hypoglycaemic effects among the antidiabetic drugs analysed. Long‐acting GLP‐1r appears to be more useful for T2DM patients inadequately controlled with metformin monotherapy.
Thrombotic microangiopathy associated with gemcitabine use: Presentation and outcome in a national French retrospective cohort
Authors: Daviet Florence , Rouby Franck , Poullin Pascale , Moussi‐Francès Julie , Sallée Marion , Burtey Stéphane , Mancini Julien , Duffaud Florence , Sabatier Renaud , Pourroy Bertrand , Grandvuillemin Aurélie , Grange Steven , Frémeaux‐Bacchi Véronique , Coppo Paul , Micallef Joëlle , Jourde‐Chiche Noémie 
Published: November 2018

AimsGemcitabine has been associated with thrombotic microangiopathy (TMA). We conducted a national retrospective study of gemcitabine‐associated TMA (G‐TMA).MethodsFrom 1998 to 2015, all cases of G‐TMA reported to the French Pharmacovigilance Network and the French TMA Reference Center, and cases explored for complement alternative pathway abnormalities, were analysed.ResultsG‐TMA was diagnosed in 120 patients (median age 61.5 years), after a median of 210 days of treatment, and a cumulative dose of 12 941 mg m–2. Gemcitabine indications were: pancreatic (52.9%), pulmonary (12.6%) and breast (7.6%) cancers, metastatic in 34.2% of cases. Main symptoms were oedema (56.7%) and new‐onset or exacerbated hypertension (62.2%). Most patients presented with haemolytic anaemia (95.6%) and thrombocytopenia (74.6%). Acute kidney injury was reported in 97.4% and dialysis was required in 27.8% of patients. Treatment consisted of: plasma exchange (PE; 39.8%), fresh frozen plasma (21.4%), corticosteroids (15.3%) and eculizumab (5.1%). A complete remission of TMA was obtained in 42.1% of patients and haematological remission in 23.1%, while 34.7% did not improve. The survival status was known for 52 patients, with 29 deaths (54.7%). Patients treated with PE, despite a more severe acute kidney injury, requiring dialysis more frequently, displayed comparable rates of remission, but with more adverse events. No abnormality in complement alternative pathway was documented in patients explored.ConclusionThis large cohort confirms the severity of G‐TMA, associated with severe renal failure and death. Oedema and hypertension could be monitored in patients treated with gemcitabine to detect early TMA. The benefit of PE or eculizumab deserves further investigation.
A long winter for the Red Queen: rethinking the evolution of seasonal migration
Authors: Winger Benjamin M. , Auteri Giorgia G. , Pegan Teresa M. , Weeks Brian C. 
Published: November 2018

AbstractThis paper advances an hypothesis that the primary adaptive driver of seasonal migration is maintenance of site fidelity to familiar breeding locations. We argue that seasonal migration is therefore principally an adaptation for geographic persistence when confronted with seasonality – analogous to hibernation, freeze tolerance, or other organismal adaptations to cyclically fluctuating environments. These ideas stand in contrast to traditional views that bird migration evolved as an adaptive dispersal strategy for exploiting new breeding areas and avoiding competitors. Our synthesis is supported by a large body of research on avian breeding biology that demonstrates the reproductive benefits of breeding‐site fidelity. Conceptualizing migration as an adaptation for persistence places new emphasis on understanding the evolutionary trade‐offs between migratory behaviour and other adaptations to fluctuating environments both within and across species. Seasonality‐induced departures from breeding areas, coupled with the reproductive benefits of maintaining breeding‐site fidelity, also provide a mechanism for explaining the evolution of migration that is agnostic to the geographic origin of migratory lineages (i.e. temperate or tropical). Thus, our framework reconciles much of the conflict in previous research on the historical biogeography of migratory species. Although migratory behaviour and geographic range change fluidly and rapidly in many populations, we argue that the loss of plasticity for migration via canalization is an overlooked aspect of the evolutionary dynamics of migration and helps explain the idiosyncratic distributions and migratory routes of long‐distance migrants. Our synthesis, which revolves around the insight that migratory organisms travel long distances simply to stay in the same place, provides a necessary evolutionary context for understanding historical biogeographic patterns in migratory lineages as well as the ecological dynamics of migratory connectivity between breeding and non‐breeding locations.
Alveolar ridge preservation using an open membrane approach for sockets with bone deficiency: A randomized controlled clinical trial
Authors: Sun Dong‐Joo , Lim Hyun‐Chang , Lee Dong‐Woon 
Published: November 2018

AbstractBackgroundVarious approaches are used for alveolar ridge preservation (ARP); however, there is no standard method or material.PurposeTo investigate the effect of ARP with a dense polytetrafluoroethylene (d‐PTFE) membrane and freeze‐dried irradiated allogenic bone for sockets with bone deficiency.Materials and MethodsThirty‐four patients (with sockets exhibiting ≥3 mm hard tissue loss in ≥1 walls) were randomized to undergo natural socket healing (control) or ARP with a d‐PTFE membrane and freeze‐dried irradiated allogenic bone (test group). After 4 months, horizontal and vertical ridge changes were measured using cone beam computed tomography.ResultsRidge width at l mm below the ridge crest demonstrated significantly less change in the test group (median =2.3; Q1 = 0.6; Q3 = 4.3 mm) than in the control group (median =3.9; Q1 =2.6; Q3 = 7.8 mm; P = .021). There was no significant difference between the two groups in horizontal ridge changes at 3 and 5 mm below the crest or vertical changes (P > .05). Requirement for bone augmentation at implant placement was significantly reduced in the test group compared to the control group (P < .001).ConclusionARP with a d‐PTFE membrane and freeze‐dried irradiated allogenic bone substitute reduced horizontal bone resorption in sockets with bone deficiency.