bluuebunny/crossref_metadata_2025_split huggingface dataset:
Coronary artery calcium and carotid artery intima-media thickness for the prediction of stroke and benefit from statins
Authors: Osawa Kazuhiro , Trejo Maria Esther Perez , Nakanishi Rine , McClelland Robyn L , Blaha Michael J , Blankstein Ron , McEvoy John W , Ceponiene Indre , Stein James H , Sacco Ralph L , Polak Joseph F , Budoff Matthew J 
Published: September 2018

Background Current guidelines suggest treatment for many individuals who may never develop a stroke. We hypothesized that a combination of coronary artery calcification (CAC) and carotid artery intima-media thickness (C IMT) data could better individualize risk assessment for ischemic stroke and transient ischemic attack events. Methods A total of 4720 individuals from the Multi-Ethnic Study of Atherosclerosis were evaluated for ischemic stroke and transient ischemic attack. Cox proportional hazards models for time to incident ischemic stroke/transient ischemic attack were used to examine CAC and CIMT as ischemic stroke/transient ischemic attack predictors in addition to traditional risk factors. We calculated the 10-year number needed to treat by applying the benefit observed in ASCOT-LLA to the observed event rates within CAC and CIMT strata. Results Median follow-up was 13.1 years. Compared with individuals with no CAC and with CIMT ≤ 75th percentile, stroke/transient ischemic attack risk increased progressively with each CAC category (0, 1–100, >100) among individuals with CIMT > 75th percentile. Among participants eligible for statin therapy based on the 2013 atherosclerotic cardiovascular disease (ASCVD) guidelines (ASCVD risk of >5%), 739/2906 (25%) had no CAC and CIMT ≤ 75th percentile and an observed ischemic stroke/transient ischemic attack rate of 2.49 per 1000 person-years. The predicted 10-year number needed to treat was 292 for no CAC and CIMT ≤ 75th percentile and 57 for CAC > 100 and CIMT > 75th percentile. Conclusion The combination of CIMT and CAC could serve to further refine risk calculation for ischemic stroke/transient ischemic attack prevention and may prioritize those in most need of statin therapy to reduce ischemic stroke/transient ischemic attack risk.
Utilization Outcomes of a Pilot Primary Care Team Redesign
Authors: Landrey Alison R. , Harder Valerie S. , Sandoval Marie B. , King John G. , Ziegelman David S. , MacLean Charles D. 
Published: September 2018

Objectives: To evaluate the effect of a team-based primary care redesign on primary care, emergency department (ED) and urgent care (UC) utilization, and new patient access to primary care. Study Design: A retrospective pre–post difference-in-differences analysis of utilization outcomes for patients on a redesigned primary care team compared to a standard primary care group. Methods: Within a patient-centered medical home, a pilot team was developed comprising 2 colocated “teamlets” of 1 physician, 1 nurse practitioner (NP), 1 registered nurse (RN), and 2 licensed practical nurses (LPNs). The redesigned team utilized physician–NP comanagement, expanded roles for RNs and LPNs, and dedicated provider time for telephone and e-mail medicine. We compared changes in number of office, ED, and UC visits during the implementation year for patients on the redesigned team compared to patients receiving the standard of care in the same clinic. Proportion of new patient visits was also compared between the pilot and the control groups. Results: There were no differences between the redesign group and control group in per-patient mean change in office visits (Δ = −0.04 visits vs Δ = −0.07; P = .98), ED visits (Δ = 0.00 vs Δ = 0.01; P = .25), or UC visits (Δ = 0.00 vs Δ = 0.05; P = .08). Proportion of new patient visits was higher in the pilot group during the intervention year compared to the control group (6.6% vs 3.9%; P < .0001). Conclusions: The redesign did not significantly impact ED, UC, or primary care utilization within 1 year of follow-up. It did improve access for new patients.
A phase 2 study of ruxolitinib in combination with azacitidine in patients with myelofibrosis
Authors: Masarova Lucia , Verstovsek Srdan , Hidalgo-Lopez Juliana E. , Pemmaraju Naveen , Bose Prithviraj , Estrov Zeev , Jabbour Elias J. , Ravandi-Kashani Farhad , Takahashi Koichi , Cortes Jorge E. , Ning Jing , Ohanian Maro , Alvarado Yesid , Zhou Lingsha , Pierce Sherry , Gergis Romany , Patel Keyur P. , Luthra Rajyalakshmi , Kadia Tapan M. , DiNardo Courtney D. , Borthakur Gautam , Bhalla Kapil , Garcia-Manero Guillermo , Bueso-Ramos Carlos E. , Kantarjian Hagop M. , Daver Naval 
Published: September 2018

Key Points
The combination of RUX and AZA was safe with encouraging spleen response rates at 24 weeks and any time on study. RUX and AZA demonstrated marked improvements in bone marrow fibrosis at 24 months when compared with RUX alone.
Alterations in platelet secretion differentially affect thrombosis and hemostasis
Authors: Joshi Smita , Banerjee Meenakshi , Zhang Jinchao , Kesaraju Akhil , Pokrovskaya Irina D. , Storrie Brian , Whiteheart Sidney W. 
Published: September 2018

Key PointsVAMP isoforms regulate the kinetics and extent of platelet granule exocytosis. Manipulating platelet sensitive factor attachment protein receptors alters granule secretion, which affects the hemostatic balance.
High-flow nasal oxygen versus noninvasive ventilation in adult patients with cystic fibrosis: a randomized crossover physiological study
Authors: Sklar Michael C. , Dres Martin , Rittayamai Nuttapol , West Brent , Grieco Domenico Luca , Telias Irene , Junhasavasdikul Detajin , Rauseo Michela , Pham Tai , Madotto Fabiana , Campbell Carolyn , Tullis Elizabeth , Brochard Laurent 
Published: September 2018

Abstract
Background
Noninvasive ventilation (NIV) is the first-line treatment of adult patients with exacerbations of cystic fibrosis (CF). High-flow nasal oxygen therapy (HFNT) might benefit patients with hypoxemia and can reduce physiological dead space. We hypothesized that HFNT and NIV would similarly reduce work of breathing and improving breathing pattern in CF patients. Our objective was to compare the effects of HFNT versus NIV in terms of work of breathing, assessed noninvasively by the thickening fraction of the diaphragm (TFdi, measured with ultrasound), breathing pattern, transcutaneous CO2 (PtcCO2), hemodynamics, dyspnea and comfort.

Methods
Adult CF patients who had been stabilized after requiring ventilatory support for a few days were enrolled and ventilated with HFNT and NIV for 30 min in crossover random order.

Results
Fifteen patients were enrolled. Compared to baseline, HFNT, but not NIV, reduced respiratory rate (by 3 breaths/min, p = 0.01) and minute ventilation (by 2 L/min, p = 0.01). Patients also took slightly larger tidal volumes with HFNT compared to NIV (p = 0.02). TFdi per breath was similar under the two techniques and did not change from baseline. MAP increased from baseline with NIV and compared to HFNT (p ≤ 0.01). Comfort was poorer with the application of both HFNT and NIV than baseline. No differences were found for heart rate, SpO2, PtcCO2 or dyspnea.

Conclusions
In adult CF patients stabilized after indication for ventilatory support, HFNT and NIV have similar effects on diaphragmatic work per breath, but high-flow therapy confers additional physiological benefits by decreasing respiratory rate and minute ventilation.

Clinical trial registration
Ethics Committee of St. Michael’s Hospital (REB #14-338) and clinicaltrial.gov (NCT02262871).
Assessing the Content of Television Health Insurance Advertising during Three Open Enrollment Periods of the ACA
Authors: Barry Colleen L. , Bandara Sachini , Arnold Kimberly T. , Pintor Jessie K. , Baum Laura M. , Niederdeppe Jeff , Karaca-Mandic Pinar , Fowler Erika Franklin , Gollust Sarah E. 
Published: September 2018

Abstract
Television advertising has been a primary method for marketing new health plans available under the Affordable Care Act (ACA) to consumers. Data from Kantar Media's Campaign Media Analysis Group were used to analyze advertising content during three ACA open enrollment periods (fall 2013 to spring 2016). Few advertisement airings featured people who were elderly, disabled, or receiving care in a medical setting, and over time airings increasingly featured children, young adults, and people exercising. The most common informational messages focused on plan choice and availability of low-cost plans, but messages shifted over open enrollment cycles to emphasize avoidance of tax penalties and availability of financial assistance. Over the three open enrollment periods, there was a sharp decline in explicit mentions of the ACA or Obamacare in advertisements. Overall, television advertisements have increasingly targeted young, healthy consumers, and informational appeals have shifted toward a focus on financial factors in persuading individuals to enroll in marketplace plans. These advertising approaches make sense in the context of pressures to market plans to appeal to a sufficiently large, diverse group. Importantly, dramatic declines over time in explicit mention of the law mean that citizens may fail to understand the connection between the actions of government and the benefits they are receiving.
Targeted DamID reveals differential binding of mammalian pluripotency factors
Authors: Cheetham Seth W. , Gruhn Wolfram H. , van den Ameele Jelle , Krautz Robert , Southall Tony D. , Kobayashi Toshihiro , Surani M. Azim , Brand Andrea H. 
Published: September 2018

ABSTRACT
The precise control of gene expression by transcription factor networks is crucial to organismal development. The predominant approach for mapping transcription factor-chromatin interactions has been chromatin immunoprecipitation (ChIP). However, ChIP requires a large number of homogeneous cells and antisera with high specificity. A second approach, DamID, has the drawback that high levels of Dam methylase are toxic. Here, we modify our targeted DamID approach (TaDa) to enable cell type-specific expression in mammalian systems, generating an inducible system (mammalian TaDa or MaTaDa) to identify genome-wide protein/DNA interactions in 100 to 1000 times fewer cells than ChIP-based approaches. We mapped the binding sites of two key pluripotency factors, OCT4 and PRDM14, in mouse embryonic stem cells, epiblast-like cells and primordial germ cell-like cells (PGCLCs). PGCLCs are an important system for elucidating primordial germ cell development in mice. We monitored PRDM14 binding during the specification of PGCLCs, identifying direct targets of PRDM14 that are key to understanding its crucial role in PGCLC development. We show that MaTaDa is a sensitive and accurate method for assessing cell type-specific transcription factor binding in limited numbers of cells.
Study on the Isomerization of Amphiphilic Azobenzene Cored Dendrimer and Its Molecular Environment
Authors: Mamiya Michitaka , Fukushima Shun , Arai Tatsuo 
Published: September 2018

Abstract
3,3′,5,5′-tetramethoxy azobenzene (TMAB) and amphiphilic azobenzene dendrimers (AGn-azo) bearing triethylene glycol were synthesized and their isomerization behavior investigated. The solvation structures and isomerization behavior of AGn-azo were expected to change with solvent and generation.
CT texture analysis of the liver for assessing hepatic fibrosis in patients with hepatitis C virus
Authors: Lubner Meghan G , Jones Daniel , Kloke John , Said Adnan , Pickhardt Perry J 
Published: September 2018

Objective:
To evaluate CT texture analysis (CTTA) for non-invasively staging of hepatic fibrosis (stages F0-F4) in a cohort of patients with hepatitis C virus (HCV).

Methods:
Quantitative texture analysis of the liver was performed on abdominal multidimensional CT scans. Single slice region of interest measurements of the total liver, Couinaud segments IV–VIII and segments I–III were made. CT texture parameters were tested against stage of hepatic fibrosis in segments IV–VIII on the portal venous phase. Texture parameters were correlated with biopsy performed within 1 year for all cases with intermediate fibrosis (F0–F3).

Results:
CT scans of 556 adults (360 males, 196 females; mean age, 49.8 years), including a healthy control group (F0, n = 77) and patients with hepatitis C virus and Stage 0 disease (n = 49), and patients with increasing stages of fibrosis (F1, n = 80; F2 n = 99; F3 n = 87; F4 n = 164) were evaluated. Mean gray level intensity increased with increasing fibrosis. For significant fibrosis (≥F2), mean showed receiver operatingcharacteristic area under the curve (AUC) of 0.80 with sensitivity and specificity of 74 and 75% using a threshold of 0.44, with similar receiver operatingcharacteristic AUC and sensitivity/specificity for advanced fibrosis (≥F3). Skewness and kurtosis were inversely associated with hepatic fibrosis, most prominently in cirrhotic patients. A multivariate model combining these four texture features (mean, mpp, skewness and kurtosis) showed slightly improved performance with AUC of 0.82, 0.82 and 0.86 for any fibrosis (F0 vs F1–F4), significant fibrosis (F0–1 vs F2–4) and advanced fibrosis (F0–2 vs F3–4) respectively.

Conclusion:
CT texture features may be associated with hepatic fibrosis and have utility in staging fibrosis, particularly at advanced levels.

Advances in knowledge:
CTTA may be helpful in detecting and staging hepatic fibrosis, particularly at advanced levels. CT measures like CTTA can be retrospectively evaluated without special equipment.
Commodity Price Forecasts, Futures Prices, and Pricing Models
Authors: Cortazar Gonzalo , Millard Cristobal , Ortega Hector , Schwartz Eduardo S. 
Published: September 2018

Even though commodity-pricing models have been successful in fitting the term structure of futures prices and its dynamics, they do not generate accurate true distributions of spot prices. This paper develops a new approach to calibrate these models using not only observations of oil futures prices, but also analysts’ forecasts of oil spot prices. We conclude that to obtain reasonable expected spot curves, analysts’ forecasts should be used, either alone or jointly with futures data. The use of both futures and forecasts, instead of using only forecasts, generates expected spot curves that do not differ considerably in the short/medium term, but long term estimations are significantly different. The inclusion of analysts’ forecasts in addition to futures, instead of only futures prices, does not alter significantly the short/medium part of the futures curve but does have a significant effect on long-term futures estimations. This paper was accepted by Gustavo Manso, finance.
Chinese international students in New Zealand: Views of citizenship and democracy
Authors: Zhang Xiudi 
Published: September 2018

Abstract
Using a case study approach utilizing individual interviews and focus groups, this study examines how Chinese students studying in New Zealand view their citizenship. The focus was on students’ everyday understandings of citizenship after they had some experience of living outside of China in a different citizenship regime. What does citizenship mean to them, given that they are studying in the social context of a democracy in comparison with communist China? Does the transition from life in a communist country to life in a democratic country affect their sense of citizenship? The results showed Chinese international students raised questions about their past citizenship experiences in communist China and how they were influenced by their personal politico-cultural experiences of individualism in New Zealand. As a result, students struggled to understand the meanings of ‘citizen’ and ‘democracy’ and the challenges to their thinking of New Zealand’s democratic context. The advantages of democracy so well understood in the West may not be self-evident to students raised in a system with different values. In general, they formulated different understandings of themselves as citizens in China. The discomforting process of reassessment of citizenship is not always appreciated by Western academics who study Chinese citizenship using Western criteria.
Tapestries of resilience: An arts-based approach to enhancing the resilience of World Vision’s humanitarian staff
Authors: Ma Lama Majaj , Penner Crystal M. 
Published: September 2018

Abstract
Responding to the impact, community and individuals during a crisis is demanding for humanitarian workers. The need for resilience is crucial for the delivery of effective humanitarian aid and staff long-term emotional endurance. This article describes an arts-based approach aimed at enhancing the resilience of 53 World Vision (WV) staff in Asia at a weeklong Regional Disaster Management Team (RDMT) workshop. The purpose was to introduce responders to embodied artful experiences to develop coping skills and enhance their personal resilience to the impact of the response before, during and after deployment. The arts-based experiential sessions were embraced by the participants, with many acknowledging that they will engage in the arts as a reflexive practice during deployment.
Arts-based disaster relief: Theory and practice
Authors: Schwartz Samuel 
Published: September 2018

Abstract
Disasters and disaster relief have been the subject of academic study for more than half a century. Psychological assistance is an important part of the process. Researchers have identified a number of recurring problems that emerge during interventions. Arts-based disaster relief offers important and unique advantages and provides answers to some of these problems. The article presents and analyses four examples of arts-based disaster relief programmes, identifying how they succeed in overcoming some frequently encountered difficulties. It concludes by noting enduring problems that arts-based disaster relief needs to resolve in the future.
Host-response biomarkers for the diagnosis of bacterial respiratory tract infections
Authors: Saleh Mohammed A.A. , van de Garde Ewoudt M.W. , van Hasselt J.G. Coen 
Published: September 2018

AbstractAppropriate antibiotic treatment for respiratory tract infections (RTIs) necessitates rapid and accurate diagnosis of microbial etiology, which remains challenging despite recent innovations. Several host response-based biomarkers due to infection have been suggested to allow discrimination of bacterial and non-bacterial microbial RTI etiology. This review provides an overview of clinical studies that investigated the diagnostic performance of host-response proteomic biomarkers to identify RTI microbial etiology. Procalcitonin and C-reactive protein have been studied most extensively; whereof procalcitonin has demonstrated the strongest diagnostic performance compared to other biomarkers. Proadrenomedullin, soluble triggering receptor expressed on myeloid cells-1, neopterin and pentraxin-3 need more studies to confirm their diagnostic value. For syndecan-4 and lipocalin-2 currently insufficient evidence exists. Common limitations in several of the studies were the relatively small scale setting, heterogeneous patient population and the absence of statistical power calculation.
Utilization of indocynanine green fluorescent imaging (ICG-FI) for the assessment of microperfusion in vascular medicine
Authors: Duprée Anna , Rieß Henrik , Detter Christian , Debus Eike S. , Wipper Sabine H. 
Published: September 2018

AbstractIntraoperative valuation of organ and tissue microperfusion is always a current topic in different surgical situations. Although indocyanine green fluorescent imaging (ICG-FI) has turned to be a more and more common technique to evaluate organ perfusion, only few studies tried to quantitatively validate the technique for microperfusion assessment. The aim of the following manuscript is to present the results of our interdisciplinary research confirming additional quantitative assessment tools in different surgical conditions. Thus, we are implementing the background-subtracted peak fluorescent intensity (BSFI), the slope of fluorescence intensity (SFI), and the time to slope (TTS) using ICG-FI in several regions of interest (ROI).
Crystal structure of [tris(2-benzimidazolylmethyl)amine-κ4
N,N′,N′′,N′′′]-[(pyridine-2,6-dicarboxylato-κ2
O,N)]cadmium(II)–methanol (1:3) C34H36CdN8O7
Authors: Jing Chen , Lingcong Zhang , Jingwen Chen , Haodong Zhang 
Published: September 2018

Abstract
C34H36CdN8O7, monoclinic, P21/n (no. 14), a = 14.863(3) Å, b = 13.184(3) Å, c = 17.202(3) Å, β = 91.33(3)°, V = 3369.8(12) Å3, Z = 4, R
gt(F) = 0.0311, wR
ref(F
2) = 0.0825, T = 113(2) K.
The Law and the Line: The Literary Mirroring of a Paradigm
Authors: dalla Massara Tommaso 
Published: September 2018

Abstract
The essay deals with the topic of “border” in the light of the conceptual and etymological link between ideas of Law and Line. Starting from the mythological origins of Rome, passing through Kafka and Shakespeare, Defoe and Dostoyevsky, both the multiform and ancestral need of drawing juridical lines and the consequences of their overcoming are highlighted. The line, seen as both a territorial and a metaphorical border, as a boundary between “what is mine” from “what is yours,” as a separation between what is allowed and what is not, is described as a well-marked sign, reminding Kandinsky’s paintings, but also as a concept sometimes indeterminate, especially when we consider certain “foggy issues” of the contemporary times, such as the proprietary relationship between a person and its body.
Teilhabe- und Inklusionsforschung als wichtige Ansätze zur Förderung von Gesundheit und Teilhabe in der Arbeitswelt
Authors: Groth Susanne , Niehaus Mathilde 
Published: September 2018

Zusammenfassung
Inklusions- und Teilhabeforschung haben eine immer größere Bedeutung innerhalb und neben der Rehabilitations-, Versorgungs- und Public-Health-Forschung gewonnen. Da Inklusions- und Teilhabeforschung das emanzipatorische Ziel der Inklusion verfolgen und partizipativ ausgerichtete Forschungsmethoden nutzen, gewinnen sie für die Forschung zur Teilhabe am Arbeitsleben an Relevanz.
Public Health als akademische Ausbildung – wo stehen wir 2018?
Authors: Pundt Johanne , Dierks Marie-Luise 
Published: September 2018

Zusammenfassung
Akademische Qualifizierungen in Public Health finden in Deutschland in verschiedenen Einrichtungen statt, in unterschiedlicher Intensität und auch mit z. T. unterschiedlichen Bezeichnungen. Dieser Beitrag skizziert einen Überblick über die historischen Entwicklungen der aktuellen Studiengangsangebote und beschreibt relevante Erfolge und Herausforderungen für eine Weiterentwicklung der Studiengänge.
Effects of Aggregate Packing on Concrete Strength and Consistency
Authors: Antunes Rodrigo , Tia Mang 
Published: September 2018

Abstract
Designing concrete based on aggregate packing and optimized gradations can result in 25 % less cement content to reach a targeted compressive strength and less water-reducing admixture to obtain a required consistency. In this research, two studies were conducted: (1) an experimental analysis to determine the effects of aggregate packing on concrete strength and consistency; and (2) an investigation of the relationship between the traditional dry-rodded and the vibrated aggregate packing. Excellent correlation was found between 240 packing results, which can be applied to the modified mixture design method presented. Also, 40 slump and 120 compressive strength standard tests were performed to evaluate the effects of reducing cement content by 7.5, 15, 20, and 25 % to slump and compressive strength of concrete mixtures. The compressive strength of the optimized mixture demonstrated less susceptibility to variations due to cement content reductions when compared to nonoptimized mixtures. The Modified Coarse Factor Chart can be used to design an optimized concrete mixture efficiently in conjunction with aggregate gradation and packing, cement content, and concrete consistency.