bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of Curcuma longa extract on the expression level of brain transporters in in vivo model
Authors: Bukowska Marta , Bogacz Anna , Wolek Marlena , Mikołajczak Przemysław Ł. , Olbromski Piotr , Kamiński Adam , Czerny Bogusław 
Published: May 2019

Summary

Introduction: Blood brain barrier and multidrug resistance phenomenon are subjects of many investigations. Mainly, because of their functions in protecting the central nervous system (CNS) by blocking the delivery of toxic substances to the brain. This special function has some disadvantages, like drug delivery to the brain in neurodegenerative diseases

Objective: The aim of this study was to examine how natural and synthetic substances affect the expression levels of genes (Mdr1a, Mdr1b, Mrp1, Mrp2, Oatp1a4, Oatp1a5 and Oatp1c1) that encode transporters in the blood-brain barrier.

Methods: cDNA was synthesized from total RNA isolated from rat hippocampus. The expression level of genes was determined using real-time PCR (RT-PCR) method.

Results: Our findings showed that verapamil, as a synthetic substance, caused the greatest reduction of mRNA level of genes studied. The standardized extract of Curcuma longa reduced the expression level for Mrp1 and Mrp2, whereas the increase of mRNA level was observed for Mdr1b, Oatp1a5 and Oatp1c1.

Conclusions: These results suggests that herbal extracts may play an important role in overcoming the blood brain barrier during pharmacotherapy.
Ethnobotanical study of traditional herbal plants used by local people of Seshachalam Biosphere Reserve in Eastern Ghats, India
Authors: Reddy Araveeti Madhusudhana , Babu Madha Venkata Suresh , Rao Ramachandra Raghavendra 
Published: May 2019

Summary

Introduction: Ethnobotany is the study of medicinal plants used by local people, with particular importance of old-styled tribal beliefs and information. Ethnobotanical studies focus on ethnic knowledge of Adivasi people and development of data bases on ethnic knowledge but also focuses on preservation and regeneration of traditional beliefs and maintenance of traditional knowledge.

Objective: The aim of present study is to highlight the traditional actions of herbal plants used by inborn Yanadi community of Seshachalam Biosphere Reserve, Eastern Ghats of Andhra Pradesh, India.

Methods: The ethnobotanical field survey was conducted according to the methods adopted by some authors. In-depth interviews, interactions were conducted with tribal physicians of Yanadi, Nakkala and Irula as well as other tribes practicing and experiencing the use of plant-based medicine. A normal inquiry form was used to gather the appropriate data on herbal plants and their usage of inborn people’s lifestyle. Extensive consultations among local people and detailed documentation of the usage of plants were carried out

Results: A total of 266 medicinally used plant species belonging to 216 genera and 88 families were recognized with help of inborn herbal healers. The study also chronicled the mode of herbal arrangements, mode of the use of herbal plants in various disorders. The study exposed that native people of Seshachalam Biosphere Reserve have good medicinal information and also have preserved plant-based medicinal system of their ascendants used all their diseases. Most of medicinal plants are used in the treatment of indigestion, snake bite and skin diseases. The authors feel that this type of study certainly helps identify ethnic leads for drug development in future.

Conclusions: The ethnobotanical investigation of Seshalam Biosphere area has revealed that the tribes possess good knowledge on plant-based medicine but as they are towards in advanced exposure to transformation, their information on traditional uses of plants is slowly getting eroded. The authors plead for intensive crosscultural studies involving all ethnic tribes in the country for prioritizing or short listing of ethnic leads for various disorders for ultimately developing global level drugs for human welfare and economy development.
The Optimal Control of Two Work-Stealing Deques, Moving One After Another in a Shared Memory
Authors: Барковский Евгений Александрович , Лазутина Анна Александровна , Соколов Андрей Владимирович 
Published: May 2019

В work-stealing балансировщиках параллельных задач, каждое ядро имеет свой буфер задач—дек (англ. deque). Владелец дека использует один конец для добавления и извлечения задач, а из второго конца задачи перехватываются другими ядрами. В статье анализируются два метода представления деков: один из распространенных методов—раздельное последовательное циклическое представление деков; и новый предложенный нами метод, где общая память для деков заранее не делится и они двигаются друг за другом по кругу. Ранее эти методы анализировались нами для представления FIFO-очередей в сетевых приложениях, где для некоторых значений параметров системы метод «Друг за другом» давал лучший результат.
Целью исследования является построение и анализ модели процесса работы с двумя последовательными деками, когда они двигаются друг за другом по кругу в общей памяти. Математическую модель мы будем строить как случайное блуждание по целым точкам в пирамиде. Имитационная модель строится с помощью метода Монте-Карло. Используемая стратегия work-stealing—перехват одного элемента. Предложены математическая и имитационная модели данного процесса и проведены численные эксперименты.
Pengendalian Persediaan Produk Obat Herbal pada Permintaan Probabilistik Menggunakan Joint Economic Lot Size
Authors: Heryanto Rainisa Maini , Setiawan Yosi Thedi , Arisandhy Vivi 
Published: May 2019

Integration in supply chain is an important factor to consider. Good integration between entity in supply chain can give some advantages from minimize cost to competitiveness between supply chain. Company X is manufacturer of herbs medicine which has single distributor to sell the product. Currently, manufacturer and distributor have their inventory control policies and there is no coordination among echelon. It causes the difference number of production lot from manufacturer and the number of order from distributor, consequently total inventory cost become expensive.This research will propose Joint Economic Lot Size (JELS) method that can integrate these two echelons and will give the minimum total inventory cost. The proposed JELS method is integration between Cardenas-Barron model about EPQ backorder and Ben-Daya and Hariga model about integration model between single supplier and single consumer. Calculation process begin with forecasting demand, calculation of actual inventory control at echelon manufacturer and distributor, and calculation of proposed method. The result of calculation process show that total actual inventory cost is 5.500.371,476 IDR/month and the proposed method give 4.604.766,665 IDR/month. The proposed method can give saving about 895.604,811 IDR/month or 16,28%. Key words: cost, integration, JELS, inventory
Biología e inmunopatogénesis del carcinoma espinocelular y el basocelular
Authors: Mejía Ana María , Velásquez Margarita María 
Published: May 2019

El cáncer de piel es el tipo de cáncer más frecuente. El cáncer de piel no melanoma incluye el carcinoma basocelular y el carcinoma espinocelular. Debido a que la mayoría son poco agresivos y a que algunos se resecan sin estudio histopatológico, existe un subregistro. Esta revisión se enfoca en los aspectos más importantes de la biología y la inmunopatogénesis del carcinoma basocelular y del espinocelular.Los factores de riesgo incluyen la exposición a los rayos ultravioleta, los fototipos 1 y 2, tener el cabello y los ojos claros, la ascendencia europea y el vivir en aéreas tropicales, entre otros. La patogénesis es compleja e involucra varias vías, entre las cuales están la apoptosis, las alteraciones del gen p53, las especies reactivas del oxígeno, el virus del papiloma humano, la inmunosupresión externa (medicamentos inmunosupresores) y la ocasionada por el sol.
Características epidemiológicas y clínicas de las onicomicosis causadas por Fusarium spp. en un centro de referencia de Bogotá, Colombia, 2001-2010
Authors: Morales Camilo Andrés , Solórzano Andrea , Rojas Aída Paola 
Published: May 2019

Introducción. Fusarium spp. es uno de los agentes etiológicos de onicomicosis por mohos no dermatofitos aislados con mayor frecuencia en todo el mundo. Sin embargo, la información disponible sobre el tema es limitada y algunas veces contradictoria, probablemente debido al escaso número de casos informados. El objetivo del estudio fue describir las características epidemiológicas y clínicas de un grupo de pacientes con diagnóstico confirmado de onicomicosis por Fusarium spp. en un centro de referencia de Bogotá, Colombia.Materiales y métodos. Se llevó a cabo un estudio descriptivo de tipo corte transversal, en el que se describieron las características epidemiológicas y clínicas de los pacientes con diagnóstico confirmado de onicomicosis por Fusarium spp. que consultaron entre el 1° de enero de 2001 y el 31 de diciembre de 2010.Resultados. Se confirmaron 95 casos de onicomicosis por Fusarium spp. en 72 mujeres (76 %) y 23 hombres (24 %), con una edad promedio de 40 años. Ocho (8,4 %) tenían insuficiencia vascular, seis (6,3 %) hipotiroidismo, y dos (2,1 %) diabetes. Las presentaciones clínicas más frecuentes fueron la onicomicosis subungular distal y lateral en 71 pacientes (74,7 %) y la distrófica total en 10 pacientes (10,5 %). Se presentó un caso de infección mixta con Neoscytalidium dimidiatum.Conclusiones. La presentación clínica más frecuente de las onicomicosis por Fusarium spp. es la subungular distal y lateral, con cromoniquia de tonos blanco y amarillo, que puede ser indistinguible de las onicomicosis causadas por dermatofitos o por otros mohos. No se encontró relación con factores de riesgo que pueden predisponer a la infección.
Inter-Relationship between Global Competitiveness and Human Development- Analytical Study of Selected Countries
Authors: Younis Mufeed Thinun , Omer Dina Ahmed 
Published: May 2019

The research aims to study the inter-relationship between global competitiveness indicators and human development indicators for selected countries (low, middle, and high income)by using Granger Test, and VAR Test. The results of the causality test showed that there is a causality relation between international competitiveness and human development.
We found global competitiveness indicators has a clear effect on human development indicators in the low, middle, and high-income countries.
IKHWANUL MUSLIMIN DAN DEMOKRASI DI MESIR
Authors: Syahab Abdullah 
Published: May 2019

Demokirasi di negara-negara mayoritas muslim bergulir sejak berakhirnya perang dunia II, bukan hanya kalangan sekuler yang mengikuti Pemilu namun gerakan Islam seperti Ikhwanul Muslimin yang dicap radikal dan identik dengan terorisme juga mengambil bagian dalam pesta demokrasi di Mesir, Walau harus berhadapan dengan pemimpin otoriter dan mengalami berbagai macam teror, penyiksaan dan pembunuhan, gerakan Islam ini tetap istiqomah bahkan pada akhirnya mendapatkan kepercayaan masyarakat Mesir.
Democratization in Muslim-majority countries has been running since the end of World War II, not just secularists who participated in the elections but Islamic movements like the Muslim Brotherhood stamped as radical and identical with terrorism also took part in the democratic party in Egypt. Despite having to deal with authoritarian leaders and experienced various kinds of terror, torture and murder, this Islamic movement still istiqomah even in the end get the trust of Egyptian society.
ISLAM WAŞATIYYAH: REFLEKSI ANTARA ISLAM MODERN DAN UPAYA MODERASI ISLAM
Authors: Deny Irawan Mohammad 
Published: May 2019

Diskursus tentang Islam moderat di dunia akademik mulai mencuat ke permukaan. bagaimana tidak? ketegangan yang muncul di Timur tengah, stagnanisasi perkembangan islam di Afrika hingga islamophobia di Eropa sangat berperan penting dalam kemunculan wacana islam moderat yang ditawarkan muslim di Indonesia. Islam di Indonesia memang memiliki kecendrungan berbeda dibandingan komunitas muslim di beberapa negara. Azyumardi Azra dalam sesi perkuliahan berulang kali mengungkapkan pentingnya pengembangan corak muslim yang diperagakan di Indonesia. Sebagai negara dengan mayoritas muslim terbesar di dunia, Indonesia juga memeragakan peranan penting dalam membuat citra Islam sedikit bergeser dari setnimen keekrasan berujung kekerasan ke Islam yang memiliki cara pandang cinta damai namun tetap berada dalam bingkai Islam.
Discourse on moderate Islam in the academic world began to stick to the surface. How come? the emerging tensions in the Middle East, the stagnantization of the development of Islam in Africa to Islamophobia in Europe play an important role in the emergence of moderate Islamic discourse offered by Muslims in Indonesia. Islam in Indonesia does have a different tendency than the Muslim community in some countries. Azyumardi Azra in a lecture session repeatedly expressed the importance of developing a modeled musical style in Indonesia. As a country with the largest Muslim majority in the world, Indonesia also demonstrates an important role in making the image of Islam slightly shifted from a set of sentiments of violence-endowed violence to Islam that has a peaceful love outlook but remains within the framework of Islam.
HAK KEPEMILIKAN TEMPAT TINGGAL BAGI WNA DI BIDANG PROPERTI
Authors: Suwardi Suwardi 
Published: May 2019

Abstract : The residential property sector in Indonesia remains attractive even though there are several factors that have hampered growth over the past two years. The ownership for singles related to property refers to Government Regulation Number 40 of 1996 concerning Building Use Rights, Business Use and Use Rights to Land; Government Regulation Number 41 of 1996 concerning Housing or Residential Houses by Foreigners Domiciled in Indonesia; Law Number 25 of 2007 concerning Investment. Secondly, foreigners can buy or own a house in Indonesia above usufructuary rights, but the maximum time period given is 10 years for land under 2000 square meters. At present, more than 50% of Indonesia's population lives in urban areas. This means that there will be more houses, apartments and condominiums to be built in Indonesian urban areas to meet growing demand. This situation also implies that due to lack of land availability in urban areas, prices tend to rise rapidly, while developers need to increasingly focus on vertical property development such as apartments and condominiums. <br /> <br />Keywords: Residential, Ownership Right by Foreigners, Property
Machine learning–based preoperative predictive analytics for lumbar spinal stenosis
Authors: Siccoli Alessandro , de Wispelaere Marlies P. , Schröder Marc L. , Staartjes Victor E. 
Published: May 2019

OBJECTIVEPatient-reported outcome measures (PROMs) following decompression surgery for lumbar spinal stenosis (LSS) demonstrate considerable heterogeneity. Individualized prediction tools can provide valuable insights for shared decision-making. The authors aim to evaluate the feasibility of predicting short- and long-term PROMs, reoperations, and perioperative parameters by machine learning (ML) methods.METHODSData were derived from a prospective registry. All patients had undergone single- or multilevel mini-open facet-sparing decompression for LSS. The prediction models were trained using various ML-based algorithms to predict the endpoints of interest. Models were selected by area under the receiver operating characteristic curve (AUC). The endpoints were dichotomized by minimum clinically important difference (MCID) and included 6-week and 12-month numeric rating scales for back pain (NRS-BP) and leg pain (NRS-LP) severity and the Oswestry Disability Index (ODI), as well as prolonged surgery (> 45 minutes), extended length of hospital stay (> 28 hours), and reoperations.RESULTSA total of 635 patients were included. The average age was 62 ± 10 years, and 333 patients (52%) were male. At 6 weeks, MCID was seen in 63%, 76%, and 61% of patients for ODI, NRS-LP, and NRS-BP, respectively. At internal validation, the models predicted MCID in these variables with accuracies of 69%, 76%, and 85%, and with AUCs of 0.75, 0.79, and 0.92. At 12 months, 66%, 63%, and 51% of patients reported MCID; the observed accuracies were 62%, 74%, and 66%, with AUCs of 0.68, 0.72, and 0.79. Reoperations occurred in 60 patients (9.5%), of which 27 (4.3%) occurred at the index level. Overall and index-level reoperations were predicted with 69% and 63% accuracy, respectively, and with AUCs of 0.66 and 0.61. In 15%, a length of surgery greater than 45 minutes was observed and predicted with 78% accuracy and AUC of 0.54. Only 15% of patients were admitted to the hospital for longer than 28 hours. The developed ML-based model enabled prediction of extended hospital stay with an accuracy of 77% and AUC of 0.58.CONCLUSIONSPreoperative prediction of a range of clinically relevant endpoints in decompression surgery for LSS using ML is feasible, and may enable enhanced informed patient consent and personalized shared decision-making. Access to individualized preoperative predictive analytics for outcome and treatment risks may represent a further step in the evolution of surgical care for patients with LSS.
Reduction and monosegmental fusion for lumbar spondylolisthesis with a long tab percutaneous pedicle screw system: “swing” technique
Authors: Park Bumsoo , Noh Sung-Hyun , Park Jeong-Yoon 
Published: May 2019

OBJECTIVEWith the development of minimally invasive procedures, percutaneous pedicle screw systems have been used to attempt to correct spondylolisthesis. No previous studies have reported on reduction measures using long tab percutaneous pedicle screws for spondylolisthesis. Additional intraoperative correction has been proposed with the “swing” technique. This study was conducted to compare the efficacy of standard minimally invasive transforaminal interbody fusion (MIS-TLIF) with the efficacy of MIS-TLIF with the “swing” technique (MIS-TLIF and swing) in lumbar spondylolisthesis.METHODSThis was a matched-control study and included 30 consecutive patients who were followed up for 6 months after surgery. Of those patients, 15 were treated with operative reduction via MIS-TLIF with the “swing” technique, whereas the other 15 were treated with the standard MIS-TLIF procedure. The swing technique is a new reduction procedure for use with long tab percutaneous screws. In the swing technique, the entire system is swung back and forth several times after all constructs are placed. Only patients with Meyerding grade I or II lumbar spondylolisthesis were included in the study (18 with grade I and 12 with grade II). Perioperative and clinical outcomes, radiological parameters (Meyerding grade, percentage of slip, slip correction rate, segmental lordosis, and lumbar lordosis) were compared between groups at 6 months after surgery.RESULTSDemographic data did not differ significantly between the 2 groups. Postoperative clinical outcomes showed significant improvement in both groups. Postoperative radiological parameters showed that the degree of spondylolisthesis (swing: 4.7% vs standard: 8.9%) and reduction rate (swing: 77.3% vs standard: 57.1%) favored the swing group. The swing technique effectively decreased the degree of spondylolisthesis (swing: 24.1% to 4.7% vs standard: 21.8% to 8.9%). No complications related to the procedure were reported.CONCLUSIONSMIS-TLIF with the “swing” technique with long tab percutaneous pedicle screws is a safe and effective reduction method for monosegmental spondylolisthesis. This technique cannot only alleviate symptoms but also achieve nearly completely reduction of slippage.
Decompression of lumbar canal stenosis with a bilateral interlaminar versus classic laminectomy technique: a prospective randomized study
Authors: Soliman Mohamed A. R. , Ali Ahmed 
Published: May 2019

OBJECTIVEThe aim of this study was to compare the radiological and clinical results of bilateral interlaminar canal decompression and classic laminectomy in lumbar canal stenosis (LCS).METHODSTwo hundred eighteen patients with LCS were randomized to surgical treatment with classic laminectomy (group 1) or bilateral interlaminar canal decompression (group 2). Low-back and leg pain were evaluated according to the visual analog scale (VAS) both preoperatively and postoperatively. Disability was evaluated according to the Oswestry Disability Index (ODI) preoperatively and at 1 month, 1 year, and 3 years postoperatively. Neurogenic claudication was evaluated using the Zurich Claudication Questionnaire (ZCQ) preoperatively and 1 year postoperatively. The two treatment groups were compared in terms of neurogenic claudication, estimated blood loss (EBL), and intra- and postoperative complications.RESULTSPostoperative low-back and leg pain declined as compared to the preoperative pain. Both groups had significant improvement in VAS, ODI, and ZCQ scores, and the improvements in ODI and back pain VAS scores were significantly better in group 2. The average EBL was 140 ml in group 2 compared to 260 ml in group 1. Nine patients in the laminectomy group developed postoperative instability requiring fusion compared to only 4 cases in the interlaminar group (p = 0.15). Complications frequency did not show any statistical significance between the two groups.CONCLUSIONSBilateral interlaminar decompression is an effective method that provides sufficient canal decompression with decreased instability in cases of LCS and increases patient comfort in the postoperative period.
Lumbar canal stenosis: analyzing the role of stabilization and the futility of decompression as treatment
Authors: Goel Atul , Ranjan Shashi , Shah Abhidha , Patil Abhinandan , Vutha Ravikiran 
Published: May 2019

OBJECTIVEThe authors report their current experience with their previously published novel form of treatment in 70 cases of lumbar canal stenosis. The treatment consisted of only fixation of the spinal segments by the transarticular screw fixation technique. No bone, ligament, osteophyte, or disc resection was done for spinal canal and neural foraminal decompression. The proposed treatment is based on the concept that vertical instability that results in telescoping of the facets on physical activity forms the nodal point of pathogenesis of lumbar canal stenosis.METHODSDuring the period June 2014 to May 2018, 70 patients presenting with the classically described symptoms of lumbar canal stenosis were treated surgically by only fixation of involved spinal segments. Apart from clinical and radiological guides, instability was diagnosed on the basis of physical observation of the status of articulation by direct manipulation of bones of the region. The operation involved transarticular insertion of 2 or 3 screws for each articulation. The Oswestry Disability Index and visual analog scale were used to assess the patients before and after surgery and at follow-up. Additionally, a personalized patient satisfaction score was used to assess the outcome of surgery.RESULTSClinical symptomatic recovery was observed in all patients in the immediate postoperative period. During the average follow-up period, 100% of patients had varying degrees of symptomatic relief. The patient satisfaction score suggested that all patients were very satisfied with the surgical procedure. The transarticular fixation technique provided strong spinal segment fixation and a reliable ground for bone arthrodesis. No patient needed any additional modality of treatment or reoperation for recurrence of symptoms.CONCLUSIONSSpinal instability is the nodal point of pathogenesis of spinal degeneration–related lumbar canal stenosis. Only fixation of the involved spinal segments is necessary—decompression by bone or soft-tissue resection is not necessary.