bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exercise Intolerance, Mortality, and Organ System Impairment in Adult Survivors of Childhood Cancer
Authors: Ness Kirsten K. , Plana Juan C. , Joshi Vijaya M. , Luepker Russell V. , Durand Jean B. , Green Daniel M. , Partin Robyn E. , Santucci Aimee K. , Howell Rebecca M. , Srivastava Deo Kumar , Hudson Melissa M. , Robison Leslie L. , Armstrong Gregory T. 
Published: October 2019

PURPOSE Exercise intolerance, associated with heart failure and death in general populations, is not well studied in survivors of childhood cancer. We examined prevalence of exercise intolerance in survivors exposed or not to cardiotoxic therapy, and associations among organ system function, exercise intolerance, and mortality. METHODS Participants consisted of 1,041 people who had survived cancer ≥ 10 years (and had or did not have exposure to anthracyclines and/or chest-directed radiation) and 285 control subjects. Exercise intolerance was defined as peak oxygen uptake < 85% predicted from maximal cardiopulmonary exercise testing; organ functions were ascertained with imaging or clinical testing. Multivariable regression of the data was performed to compare exercise capacity between survivors exposed or unexposed to cardiotoxic therapy and control subjects, and to evaluate associations between treatment and organ function, and organ function and exercise intolerance. Propensity score methods in time-to-event analyses evaluated associations between exercise intolerance and mortality. RESULTS Survivors (mean age ± standard deviation [SD], 35.6 ± 8.8 years) had lower mean (± SD) peak oxygen uptake (exposed: 25.74 ± 8.36 mL/kg/min; unexposed: 26.82 ± 8.36 mL/kg/min) than did control subjects (32.69 ± 7.75 mL/kg/min; P for all < .001). Exercise intolerance was present in 63.8% (95% CI, 62.0% to 65.8%) of exposed survivors, 55.7% (95% CI, 53.2% to 58.2%) of unexposed survivors, and 26.3% (95% CI, 24.0% to 28.3%) of control subjects, and was associated with mortality (hazard ratio, 3.9; 95% CI, 1.09 to 14.14). Global longitudinal strain (odds ratio [OR], 1.71; 95% CI, 1.11 to 2.63), chronotropic incompetence (OR, 3.58; 95% CI, 1.75 to 7.31); forced expiratory volume in 1 second < 80% (OR, 2.59; 95% CI, 1.65 to 4.09), and 1 SD decrease in quadriceps strength (OR, 1.49; 95% CI, 1.23 to 1.82) were associated with exercise intolerance. Ejection fraction < 53% was not associated with exercise intolerance. CONCLUSION Exercise intolerance is prevalent among childhood cancer survivors and associated with all-cause mortality. Treatment-related cardiac (detected by global longitudinal strain), autonomic, pulmonary, and muscular impairments increased risk. Survivors with impairments may require referral to trained specialists to learn to accommodate specific deficits when engaging in exercise.
High-speed locomotion in the Saharan silver ant, Cataglyphis bombycina
Authors: Pfeffer Sarah Elisabeth , Wahl Verena Luisa , Wittlinger Matthias , Wolf Harald 
Published: October 2019

ABSTRACT
The diurnal thermophilic Saharan silver ant, Cataglyphis bombycina, is the fastest of the North African Cataglyphis desert ant species. These highly mobile ants endure the extreme temperatures of their sand dune environment with outstanding behavioural, physiological and morphological adaptations. Surprisingly, C. bombycina has comparatively shorter legs than its well-studied sister species Cataglyphis fortis from salt pan habitats. This holds despite the somewhat hotter surface temperatures and the more yielding sand substrate. Here, we report that C. bombycina employs a different strategy in reaching high running speeds, outperforming the fastest known runs of the longer-legged C. fortis ants. Video analysis across a broad range of locomotor speeds revealed several differences to C. fortis. Shorter leg lengths are compensated for by high stride frequencies, ranging beyond 40 Hz. This is mainly achieved by a combination of short stance phases (down to 7 ms) and fast leg swing movements (up to 1400 mm s−1). The legs of one tripod group exhibit almost perfect synchrony in the timings of their lift-offs and touch-downs, and good tripod coordination is present over the entire walking speed range (tripod coordination strength values around 0.8). This near synchrony in leg movement may facilitate locomotion across the yielding sand dune substrate.
Effects of monoamine manipulations on the personality and gene expression of three-spined sticklebacks
Authors: Abbey-Lee Robin N. , Kreshchenko Anastasia , Fernandez Sala Xavier , Petkova Irina , Løvlie Hanne 
Published: October 2019

ABSTRACT
Among-individual behavioral differences (i.e. animal personality) are commonly observed across taxa, although the underlying, causal mechanisms of such differences are poorly understood. Animal personality has been correlated with physiological functions as well as fitness-related traits. Variation in many aspects of monoamine systems, such as metabolite levels and gene polymorphisms, has been linked to behavioral variation. Therefore, here we experimentally investigated the potential role of monoamines in explaining individual variation in personality, using two common pharmaceuticals that respectively alter the levels of serotonin and dopamine in the brain: fluoxetine and ropinirole. We exposed three-spined sticklebacks, a species that shows animal personality, to either chemical alone or to a combination of the two chemicals, for 18 days. During the experiment, fish were assayed at four time points for the following personality traits: exploration, boldness, aggression and sociability. To quantify brain gene expression on short- and longer-term scales, fish were sampled at two time points. Our results show that monoamine manipulations influence fish behavior. Specifically, fish exposed to either fluoxetine or ropinirole were significantly bolder, and fish exposed to the two chemicals together tended to be bolder than control fish. Our monoamine manipulations did not alter the gene expression of monoamine or stress-associated neurotransmitter genes, but control, untreated fish showed covariation between gene expression and behavior. Specifically, exploration and boldness were predicted by genes in the dopaminergic, serotonergic and stress pathways, and sociability was predicted by genes in the dopaminergic and stress pathways. These results add further support to the links between monoaminergic systems and personality, and show that exposure to monoamines can causally alter animal personality.
Future Ocean warming may prove beneficial for the northern population of European seabass, but ocean acidification does not
Authors: Howald Sarah , Cominassi Louise , LeBayon Nicolas , Claireaux Guy , Mark Felix C. 
Published: October 2019

The world's oceans are acidifying and warming due to increasing atmospheric CO2 concentrations. Thermal tolerance of fish much depends on the cardiovascular ability to supply the tissues with oxygen. The highly oxygen dependent heart mitochondria thus might play a key role in shaping an organism's tolerance to temperature. The present study aimed to investigate the effects of acute and chronic warming on respiratory capacities of European sea bass (Dicentrarchus labrax L.) heart mitochondria. We hypothesized that acute warming would impair mitochondrial respiratory capacities, but be compensated by life-time conditioning. Increasing PCO2 may additionally cause shifts in metabolic pathways by inhibiting several enzymes of the cellular energy metabolism.
Amongst others, acute warming of heart mitochondria of cold-conditioned fish increased leak respiration rates, suggesting a lower aerobic capacity to synthesize ATP with acute warming. However, thermal conditioning increased mitochondrial functionality, e.g. higher respiratory control ratios in heart mitochondria of warm-conditioned compared to cold-conditioned fish. Exposure to high PCO2 synergistically amplified the effects of acute and long-term warming, but did not result in changes by itself. We explained the high ability to maintain mitochondrial function under ocean acidification with the fact that seabass are generally able to acclimate to a variety of environmental conditions. Improved mitochondrial energy metabolism after warm conditioning could be due to the origin of this species in the warm waters of the Mediterranean. Our results also indicate that seabass are not yet fully adapted to the colder temperatures in their northern distribution range and might benefit from warmer temperatures in these latitudes.
Assessing the economic impact of climate change in the small-scale aquaculture industry of Ghana, West Africa
Authors: Asiedu Berchie , Malcolm Dickson , Iddrisu Seidu 
Published: October 2019

Background: Aquaculture in Ghana is very profitable, but faces sustainability challenges. This paper assessed the impact pathways by which climate change affects the production and profitability of small-scale aquaculture in Ghana. The study analyzed and compared the economic value of smallholder fish farms with and without the incidence of climatic parameters. Methods: Simple random sampling and purposive sampling techniques were used to select the study area and farms. A total of 30 farmers were interviewed using a questionnaire-based interview. Additionally, using document analysis, observation, and data on farms’ production input and output values, the economic impact of climate change on fish farms was assessed. Results: Extreme temperatures, erratic rainfall, floods, drought, storm and erosion are prevalent in fish farms. Available data shows a decrease of 53.4% of small-scale revenue, a 6.9% reduction in small-scale aquaculture value from GH¢ 83,000 to GH¢ 120,000 reducing fish supply by 25%. The findings indicate that the profitability, economic value, and livelihoods of the small-scale aquaculture industry is greatly affected by changes in climate. The incidence of floods, drought, erratic rainfall, erosion, and extreme temperature synergistically induce poverty. The implication on the livelihoods of fish farming households is very alarming and poses a serious threat to food security in the country. Conclusion: Based on the findings, this study concludes that; floods, rainfall temperature, and drought are the major climatic factors affecting the profitability and sustainability of the pond aquaculture industry. The preliminary recommendation is that there is an urgent need to map out flood-free zones close to perennial water bodies to overcome floods and droughts. Planting trees around ponds to create a micro-ecologies ideal for fish culture and also the construction of water storage facilities and proper dyke design would overcome drought and erosion issues. The adaptive capacity of fish-farmers must be built.
Molecular identification and phylogenetic analysis of GABA-producing lactic acid bacteria isolated from indigenous dadih of West Sumatera, Indonesia
Authors: Anggraini Lili , Marlida Yetti , Wizna Wizna , Jamsari Jamsari , Mirzah Mirzah , Adzitey Frederick , Huda Nurul 
Published: October 2019

Background: Dadih (fermented buffalo milk) is a traditional Indonesian food originating from West Sumatra province. The fermentation process is carried out by lactic acid bacteria (LAB), which are naturally present in buffalo milk. Lactic acid bacteria have been reported as one of potential producers of γ-aminobutyric acid (GABA). GABA acts as a neurotransmitter inhibitor of the central nervous system. Methods: In this study, molecular identification and phylogenetic analysis of GABA producing LAB isolated from indigenous dadih of West Sumatera were determined. Identification of the GABA-producing LAB DS15 was based on conventional polymerase chain reaction. 16S rRNA gene sequence analysis was used to identify LAB DS15. Results: PCR of the 16S rRNA gene sequence of LAB DS15 gave an approximately 1400 bp amplicon. Phylogenetic analysis showed that LAB DS15 was Pediococcus acidilactici, with high similarity of 99% at 100% query coverage to Pediococcus acidilactici strain DSM 20284. Conclusions: It can be concluded that GABA producing LAB isolated from indigenous dadih was Pediococcus acidilactici.
Case Report: Acute hemorrhagic edema of infancy (Seidlmayer purpura) – a dramatic presentation for a benign disease
Authors: Carboni Elena , Scavone Maria , Stefanelli Ettore , Talarico Valentina , Zampogna Stefania , Galati Maria Concetta , Raiola Giuseppe 
Published: October 2019

We present a case of an 11-month-old girl who was referred to our unit for an erythematous rash that appeared on the face and extremities. Personal and family history was not relevant. Laboratory tests were normal. During recovery, diameter and colour intensity of the cutaneous lesions increased, but after some weeks, lesions had a self-limited resolution without any treatment. Based on clinical and laboratory findings, a diagnosis of acute hemorrhagic edema of infancy (AHEI) was made. AHEI is a rare cutaneous leukocytoclastic vasculitis that usually affects children aged between 4 and 24 months. Etiology is unknown but almost of 75% of cases are preceded by infectious episodes, vaccinations or use of medications. In contrast to the dramatic cutaneous eruption, clinical conditions are usually optimal. Classically, AHEI is characterized by a triad of symptoms: fever, edema and purpura. Skin lesions are erythematous, annular, medallion-like, purpuric plaques that have a rapid onset and appear on the face and extremities, sparing trunk and mucosal membranes. Initially interpreted as a variant of Henoch-Schönlein purpura, now it is considered a distinct disease. In the majority of cases the disease is benign and self-limited without a visceral involvement, so a conservative approach is most often chosen.
CCL2 and IL18 expressions may associate with the anti-proliferative effect of noncontact electro capacitive cancer therapy in vivo
Authors: Pratiwi Rarastoeti , Antara Nyoman Yudi , Fadliansyah Lalu Gunawan , Ardiansyah Syamsul Arif , Nurhidayat Luthfi , Sholikhah Eti Nurwening , Sunarti Sunarti , Widyarini Sitarina , Fadhlurrahman Ahmad Ghitha , Fatmasari Hindana , Tunjung Woro Anindito Sri , Haryana Sofia Mubarika , Alamsyah Firman , Taruno Warsito Purwo 
Published: October 2019

Background: Noncontact Electro Capacitive Cancer Therapy (ECCT) is a novel treatment modality in cancer. Chemokine (C-C motif) ligand 2 (CCL2) has a major role in the outgrowth of metastatic breast cancer. Interleukin 18 (IL18) plays a role in macrophage alteration, which leads to excessive angiogenesis. This study aims to elaborate on the association of CCL2, IL18, IL23α, and TNF-α (tumor necrosis factor-alpha) expression with the anti-proliferative effect of ECCT in rat breast tumor tissue. Methods: Low intensity (18 Vpp) and intermediate frequency (150 kHz) alternating current-electric field (AC-EF) between two capacitive electrodes were exposed as external EF to a rat cage. Twenty-four rats were divided into four groups of six replicates. Breast tumor tissues were collected from 7, 12-dimethylbenz[a]anthracene (DMBA)-induced rats. Two groups were none DMBA-induced rats without ECCT exposure (NINT) and with (NIT). The other two groups were DMBA-induced rats without ECCT exposure (INT) and with (IT). Mammary glands and breast tumor tissues were collected from each group and preserved. Hematoxylin-eosin and immunohistochemistry staining were performed on paraffin sections of tissues using anti-PCNA, anti-ErbB2, anti-Caspase3, and anti-CD68. CCL2, IL18, IL23α, and TNF-α mRNA relative expressions were analyzed using qRT-PCR. Results: ECCT exposure may cause the reduction of PCNA protein expression as well as ErbB2 on breast tumor tissues, but it causes the increase of Caspase3 and macrophage CD68 protein. In rat breast tumor tissues of IT groups, the mRNA expression of CCL2 and IL18 are significantly down-regulated, in contrast with the up-regulated expression of these cytokines in tumor tissues of the INT group. IL23α and TNF- α expression remained similar in both groups. Conclusion: CCL2 and IL18 expressions have an association with the inhibition of breast tumor cell proliferation affected by ECCT exposure
The use of external fixation for the management of acute and chronic Monteggia fractures in children
Authors: Yuan Z. , Xu H. W. , Liu Y. Z. , Li Y. Q. , Li J. C. , Canavese F. 
Published: October 2019

Purpose The main objective of this study was to retrospectively evaluate the clinical and radiological outcomes of acute (AMF) and chronic Monteggia fractures (CMF) in children treated by closed or open reduction and external fixation (EF). Methods This is a retrospective review of 26 patients with Monteggia fracture. Patients with AMF (time between trauma and surgery less than two weeks) were treated by closed reduction and EF of the ulna (Group A; 15 patients) while those with CMF (time between trauma and surgery more than three weeks) were managed by closed or open reduction and EF of the ulna (Group B; 11 patients). Clinical outcome was evaluated with radiography and the short version of the Disabilities of the Arm, Shoulder and Hand outcome questionnaire (Quick DASH). Complications were recorded in both groups. Results No secondary displacement, wire migration, consolidation delays, nonunion, malunion or re-fracture was noted. However, one patient in Group A (6.7%) developed heterotopic ossification of the ulna; the final functional outcome was good (Quick DASH score: 18.2). One case of postoperative redislocation of the radial head was detected in Group B (9.1%). Two patients (7.6%) developed transient pin tract infection. Despite the fact that 16 out of 26 patients (six in Group A and ten in Group B) complained of the clinical appearance and/or had intermittent residual pain on the injured side, the results were essentially the same between the two groups of patients (p > 0.05). Conclusion EF is an alternative for the management of acute and chronic paediatric Monteggia fractures. It provides satisfactory radiological and clinical outcomes with relatively low rates of complications. Level of evidence IV
The exhibition and other learning environments in The Millbank Atlas
Authors: Bradfield Marsha , Shechter Shibboleth 
Published: October 2019

Abstract
The Millbank Atlas is an open-ended project that maps and remaps the neighbourhood of Millbank, an area of London, UK. This is home to Chelsea College of Arts (University of the Arts London) and our course, BA (Hons) Interior and Spatial Design, which has anchored the Atlas since 2016. We offer the following reflections as tutors on this course and co-researchers on the Atlas, along with our students and members of the local community. Central to this discussion is the kind of learning journey enabled by this type of project, and how it benefits from being distributed across cultural, social, geographical, discursive and other environments. This raises fundamental questions for teaching and learning, especially the potential to complicate normative assumptions in higher education about where knowledge is produced and who learns from whom.
Numerical solution of the Eikonal equation for an automatic piping
Authors: Rjasanowa Kerstin 
Published: October 2019

Abstract
The procedure of positioning of pipes, for example for the automobile exhaust construction, by the use of 3D CAD systems is difficult and time consuming because of obstacles in an engine compartment.
There are also further strong technical requirements and restrictions.
An automatic generation procedure based on the level set method and the numerical solution of the Eikonal equation is proposed.
The positions of pipes which satisfy the technical requirements are obtained using spline functions.
Characteristics of Secondary Arc Current on UHV DC and EHV AC Transmission Lines Erected on the Same Tower
Authors: XIE Yadi , HE Baina , WANG Lemiao , JIANG Renzhuo , ZHOU Yuyang , MAO Yazhe 
Published: October 2019

AbstractWith the continuous expansion of the scale of power system, corridor resources of overhead transmission lines tend to be saturated in China, making AC/DC erection on the same tower a trend in future development. The AC/DC coupling effect will cause DC line to generate secondary arc current at the point of failure when transmission line fails, which affects the DC restart. On account of the mechanism of generating secondary arc current by AC/DC lines erected on the same tower, this paper uses PSCAD to establish simulation model for AC/DC erected on the same tower. And the effects of different fault locations, lengths of coupling sections, and different transposition modes of AC lines on the secondary arc current and recovery voltage of AC and DC lines are studied. The results show that secondary arc current on DC line is greatly affected by fault location and length of coupling line, and using different transposition modes of AC lines can reduce secondary arc current on the DC lines effectively. According to Yunguang UHV DC restart time sequence, setting the restart time sequence can increase the first restart deionization time to ensure the stable operation of the system.
Twin fetal facial expressions at 30–33+6 weeks of gestation
Authors: Nitta Emiko , Kanenishi Kenji , Mori Nobuhiro , AboEllail Mohamed Ahmed Mostafa , Hata Toshiyuki 
Published: October 2019

Abstract

Objective
To assess the characteristics of twin fetal facial expressions at 30–33 + 6 weeks of gestation using four-dimensional (4D) ultrasound to clarify twin fetal brain development and maturation.

Methods
Frequencies of seven fetal facial expressions were studied using 4D ultrasound for 15 minutes in 30 singleton pregnancies and 18 twin pregnancies [four monochorionic diamniotic (MD) and 14 dichorionic diamniotic (DD) twins] at 30–33 + 6 weeks of gestation. Comparison of the frequency in each facial expression was performed between singleton and twin fetuses.

Results
Mouthing was the most frequent facial expression at 30–33 + 6 weeks of gestation, followed by blinking in twin and singleton fetuses. Both facial expressions were significantly more frequent than other expressions (P < 0.05). The frequencies of mouthing and scowling in twin fetuses were significantly lower than those in singleton fetuses, but there were no significant differences in the frequencies of the five other facial expressions between the fetal groups.

Conclusion
Our results suggest that restricted twin fetal behavior before 20 weeks of gestation may still affect the frequencies of twin facial expressions early in the third trimester of pregnancy. Moreover, the frequencies of facial expressions in twins are different from those of singleton fetuses.