bluuebunny/crossref_metadata_2025_split huggingface dataset:
Advanced Imaging to Phenotype Patients With a Systemic Right Ventricle
Authors: Helsen Frederik , Claus Piet , Van De Bruaene Alexander , Claessen Guido , La Gerche André , De Meester Pieter , Claeys Mathias , Gabriels Charlien , Petit Thibault , Santens Béatrice , Troost Els , Voigt Jens‐Uwe , Bogaert Jan , Budts Werner 
Published: October 2018

Background

Reduced ventricular function and decreased exercise capacity are widespread in adults with complete transposition of the great arteries after atrial switch (
TGA
‐Mustard/Senning) and congenitally corrected
TGA
(cc
TGA
). Advanced imaging techniques may help to better phenotype these patients and evaluate exercise cardiac response.

Methods and Results

Thirty‐three adults with a systemic right ventricle (70%
TGA
‐Mustard/Senning, 37±9 years of age, 24% female, 94% New York Heart Association class I‐
II
) underwent echocardiogram, cardiopulmonary exercise testing, and cardiovascular magnetic resonance imaging at rest and during a 4‐stage free‐breathing bicycle test. They were compared with 12 healthy controls (39±10 years of age, 25% female, all New York Heart Association class I).
TGA
‐Mustard/Senning patients had a higher global circumferential strain (−15.8±3.6 versus −11.2±5.2%,
P
=0.008) when compared with cc
TGA
, whereas global longitudinal strain and systemic right ventricle contractility during exercise were similar in both groups. Septal extracellular volume (
ECV
) in cc
TGA
was significantly higher than in
TGA
‐Mustard/Senning (30.2±2.0 versus 27.1±2.7%,
P
=0.005). During exercise,
TGA
‐Mustard/Senning had a fall in end‐diastolic volume and stroke volume (11% and 8%, respectively; both
P
≤0.002), whereas cc
TGA
could increase their stroke volume in the same way as healthy controls. Because of a greater heart rate reserve in
TGA
‐Mustard/Senning (
P
for interaction=0.010), cardiac index and peak oxygen uptake were similar between both patient groups.

Conclusions

Caution should be exercised when evaluating pooled analyses of systemic right ventricle patients, given the differences in myocardial contraction pattern, septal extracellular volume, and the exercise response of
TGA
‐Mustard/Senning versus cc
TGA
patients. Longitudinal follow‐up will determine whether abnormal exercise cardiac response is a marker of earlier failure.
100 Years of the Ocean General Circulation
Authors: Wunsch Carl , Ferrari Raffaele 
Published: October 2018

AbstractThe central change in understanding of the ocean circulation during the past 100 years has been its emergence as an intensely time-dependent, effectively turbulent and wave-dominated, flow. Early technologies for making the difficult observations were adequate only to depict large-scale, quasi-steady flows. With the electronic revolution of the past 50+ years, the emergence of geophysical fluid dynamics, the strongly inhomogeneous time-dependent nature of oceanic circulation physics finally emerged. Mesoscale (balanced), submesoscale oceanic eddies at 100-km horizontal scales and shorter, and internal waves are now known to be central to much of the behavior of the system. Ocean circulation is now recognized to involve both eddies and larger-scale flows with dominant elements and their interactions varying among the classical gyres, the boundary current regions, the Southern Ocean, and the tropics.
The South Pacific Meridional Mode and Its Role in Tropical Pacific Climate Variability
Authors: You Yujia , Furtado Jason C. 
Published: October 2018

AbstractThe Pacific meridional mode, a thermodynamically coupled mode of variability, links extratropical Pacific oceanic and atmospheric anomalies to the tropical Pacific and may give rise to El Niño–Southern Oscillation (ENSO) events. While mechanistic studies on the impacts of the North Pacific meridional mode (NPMM) are prevalent in the literature, the South Pacific meridional mode (SPMM) has only recently been examined. Reanalysis and models from the archive of phase 5 of the Coupled Model Intercomparison Project (CMIP5) are used in this study to investigate further the SPMM and its role in ENSO predictability. Akin to the NPMM, the SPMM features anomalous subtropical South Pacific sea surface temperature (SST) warming in response to a weakened South Pacific subtropical high and relaxed trade winds. However, as opposed to the NPMM, the seasonality of the SPMM SST and wind components vary out of phase, in part because of the seasonal cycle of local mixed layer depth. Thus, the SPMM and the associated wind–evaporation–SST feedback are most energetic during austral summer, facilitating interaction with the concurrent NPMM conditions to regulate the occurrence, evolution, amplitude, and diversity of ENSO events. Parallel analyses with the CMIP5 models indicate that the models reasonably capture the temporal statistics and physical processes of the observed SPMM. Nonetheless, ENSO predictability within the models relies more on the slowly evolving equatorial ocean heat content than on the meridional modes. These findings reveal how the SPMM energizes components of ENSO variability, providing an additional benchmark for model evaluation of Pacific climate variability across multiple time scales.
Evaluation of Remotely Sensed Snow Water Equivalent and Snow Cover Extent over the Contiguous United States
Authors: Dawson Nicholas , Broxton Patrick , Zeng Xubin 
Published: October 2018

Abstract
Global snow water equivalent (SWE) products derived at least in part from satellite remote sensing are widely used in weather, climate, and hydrometeorological studies. Here we evaluate three such products using our recently developed daily 4-km SWE dataset available from October 1981 to September 2017 over the conterminous United States. This SWE dataset is based on gridded precipitation and temperature data and thousands of in situ measurements of SWE and snow depth. It has a 0.98 correlation and 30% relative mean absolute deviation with Airborne Snow Observatory data and effectively bridges the gap between small-scale lidar surveys and large-scale remotely sensed data. We find that SWE products using remote sensing data have large differences (e.g., the mean absolute difference from our SWE data ranges from 45.8% to 59.3% of the mean SWE in our data), especially in forested areas (where this percentage increases up to 73.5%). Furthermore, they consistently underestimate average maximum SWE values and produce worse SWE (including spurious jumps) during snowmelt. Three additional higher-resolution satellite snow cover extent (SCE) products are used to compare the SCE values derived from these SWE products. There is an overall close agreement between these satellite SCE products and SCE generated from our SWE data, providing confidence in our consistent SWE, snow depth, and SCE products based on gridded climate and station data. This agreement is also stronger than that between satellite SCE and those derived from the three satellite SWE products, further confirming the deficiencies of the SWE products that utilize remote sensing data.
Latent Heat Nudging in the Canadian Regional Deterministic Prediction System
Authors: Jacques Dominik , Michelson Daniel , Caron Jean-François , Fillion Luc 
Published: October 2018

Abstract
This study reports on the progress toward operational weather radar data assimilation in Canada. As a first step, the latent heat nudging (LHN) technique has been tested for a period of 1 month. It is the first time that LHN is used across the North American continent, a domain significantly larger than that of other LHN studies. Other novel aspects of this study include the use of a quality index associated with individual reflectivity measurements and a discussion on matching the effective resolution of the modeled precipitation for a reduction of the representation errors. Various verification scores indicate that LHN has a positive influence on instantaneous precipitation rates for lead times up to 3 h. In comparison, the nowcasting of precipitation rates by a simple Lagrangian extrapolation method yields improvements that last up to approximately 4 h. Verifications against aircraft measurements indicate small but statistically significant improvements throughout the troposphere for lead times up to 24 h.
Allogenic Pure Platelet-Rich Plasma Therapy for Rotator Cuff Disease: A Bench and Bed Study
Authors: Jo Chris Hyunchul , Lee Seung Yeon , Yoon Kang Sup , Oh Sohee , Shin Sue 
Published: October 2018

Background: Although platelet-rich plasma (PRP) is a popular option for rotator cuff disease, the underlying mechanism of PRP and its clinical indications are unclear. Further, some kinds of PRP might be detrimental to patients. Allogenic PRP prepared through a standardized process and fully characterized could eliminate variations in PRP as well as uncertainties regarding its use in each patient, which could provide clues about its mechanism of action and indications for its use. Purpose: To assess the effects of pure PRP on tenocytes with or without inflammation in an in vitro study and to evaluate the safety and efficacy of a fully characterized pure PRP injection in patients with rotator cuff disease in a clinical study. Study Design: Controlled laboratory study and cohort study; Level of evidence, 3. Methods: For the in vitro study, tenocytes were enzymatically isolated and cultured from patients with rotator cuff tear and treated with or without interleukin 1β (IL-1β) and PRP. Gene expression and protein synthesis of pro- and anti-inflammatory cytokines, enzymes and their inhibitors, matrix synthesis, and cell viability were evaluated. For the clinical study, a total of 17 patients with rotator cuff disease received ultrasonography-guided subacromial PRP injection and were followed for 6 months. Pain, range of motion, muscle strength, shoulder function, and overall satisfaction in patients were compared with the results in a propensity score–matched control group who received corticosteroid (triamcinolone acetonide 40 mg). Results: PRP induced inflammation in the absence of inflammation and ameliorated inflammation in IL-1β-induced tendinopathic conditions by regulation of cytokines such as IL-1β, cyclooxygenase 2, microsomal prostaglandin E synthase 1, vasoactive intestinal peptide, and downstream matrix metalloproteinases. No general or local adverse events were noted with regard to allogenic PRP injection. Whereas steroid injection showed earlier improvement in some kinds of pain and functional scores, PRP generally showed comparable effects with steroid injection in all clinical outcomes at 6 months. Conclusion: This study showed that allogenic pure PRP had pleiotropic effects on tenocytes depending on inflammation and that it did not cause adverse events but rather decreased pain and improved shoulder function to a degree comparable with steroid injection in patients with rotator cuff disease. Clinical Relevance: Allogenic PRP could be a treatment option for rotator cuff disease.
Progressive reduction of serum complement levels: a risk factor for relapse in patients with hypocomplementemia in systemic lupus erythematosus
Authors: Miyawaki Y , Sada K , Asano Y , Hayashi K , Yamamura Y , Hiramatsu S , Ohashi K , Morishita M , Watanabe H , Matsumoto Y , Kawabata T , Wada J 
Published: October 2018

Objective Serologically active clinically quiescent (SACQ)-SLE is a subtype of systemic lupus erythematosus (SLE); most SACQ-SLE patients relapse. Although complement and/or anti-dsDNA level fluctuations during SACQ status are reportedly not useful for predicting relapse, they might be useful in specific clinical settings. We aimed to assess the correlation between future relapse and progressive reductions in serum complement levels following remission in patients with hypocomplementemia . Methods We retrospectively reviewed patients aged ≥15 years who were treated with ≥20 mg/day of prednisolone for remission induction. After achieving remission, the patients treated with prednisolone tapered to ≤15 mg/day without relapse and followed by hypocomplementemia (first hypocomplementemia point) were analyzed. The primary outcome was the relapse during the first 24 months. Results Seventy-six patients were enrolled; 31 (40.8%) relapsed. A ≥10% reduction after the first hypocomplementemia point in serum C3, C4, and CH50 levels was found in 10, 21, and 16 patients, respectively. Hazard ratios (95% confidence intervals) for relapse were 2.32 (0.92–5.12) for serum C3 levels and 2.46 (1.18–5.01) for serum C4 levels. Progressive reductions in serum C3 and C4 levels had relatively high specificity (93.3% and 82.2%) but limited sensitivity (22.6% and 41.9%) for predicting relapse. However, simultaneous progressive reduction in C3 levels and increase in anti-dsDNA antibody levels had the highest specificity (97.8%), and simultaneous progressive reduction in C4 levels or increase in anti-dsDNA antibody levels had the highest sensitivity (71.0%). Conclusion Simultaneous progressive reductions in complement levels and increases in anti-dsDNA antibody levels may indicate future relapse SACQ-SLE patients.
Perceived threat of Alzheimer’s disease and related dementias among older Chinese Americans in subsidized housing: Through a cultural lens
Authors: Shi Yan , Sun Fei , Liu Yanqin , Marsiglia Flavio F 
Published: October 2018

Purposes Low socioeconomic status and limited social support may put older residents in subsidized housing at high risk for developing fears of Alzheimer’s disease or related dementias. This study examined the perceived threat of Alzheimer’s disease or related dementias among older Chinese Americans in subsidized housing facilities in Phoenix, Arizona of the United States, and focused on the effect of cultural beliefs (i.e., beliefs toward Alzheimer’s disease or related dementias, and beliefs toward intergenerational support) on the perceived threat of Alzheimer’s disease or related dementias. Method Analyses were based upon a survey of 207 Chinese American older adults (Mage = 75.37, SD = 7.47) living in subsidized housing facilities in the Phoenix metropolitan area. Standardized survey questionnaires were delivered through face-to-face interviews. Results Multivariate analyses suggest that fatalism related beliefs about Alzheimer’s disease or related dementias, rather than stigmatization, were related to higher levels of concerns for developing Alzheimer’s disease or related dementias, while beliefs in intergenerational support were related to lower levels of perceived threat of Alzheimer’s disease or related dementias. However, the protective effect of beliefs in intergenerational support tended to diminish in those living with higher levels of depressive symptoms. Discussion Cultural beliefs can entail both risks and strengths when low-income Chinese American elders attempt to comprehend the implications of Alzheimer’s disease or related dementias. Health education or intervention programs need to address their fatalism beliefs toward Alzheimer’s disease or related dementias, and facilitate the accessibility of intergenerational support for this group.
Switching from originator infliximab to the biosimilar CT-P13 in 313 patients with inflammatory bowel disease
Authors: Bergqvist Viktoria , Kadivar Mohammad , Molin Daniel , Angelison Leif , Hammarlund Per , Olin Marie , Torp Jörgen , Grip Olof , Nilson Stefan , Hertervig Erik , Lillienau Jan , Marsal Jan 
Published: October 2018

Background: As the patents of originator biologics are expiring, biosimilar versions are becoming available for the treatment of inflammatory bowel disease (IBD). However, published switch studies of the first infliximab biosimilar, CT-P13, have delivered ambiguous results that could be interpreted as showing a trend towards inferior effectiveness in Crohn’s disease (CD) compared with ulcerative colitis (UC). The aim of this study was to investigate the effectiveness and safety of switching IBD patients from treatment with Remicade to CT-P13. Methods: In this prospective observational cohort study, all adult IBD patients on Remicade treatment, at four hospitals, were switched to CT-P13. The primary endpoint was change in clinical disease activity at 2, 6, and 12 months after the switch. Secondary endpoints were subgroup analyses of patients with and without concomitant immunomodulators; changes in biomarkers, quality of life, drug trough levels and anti-drug antibodies (ADAbs); and adverse events. Results: A total of 313 IBD patients were switched (195 CD; 118 UC). There were no significant changes in clinical disease activity, quality of life, biomarkers (except a small but significant increase in albumin in CD) including F-calprotectin, drug trough levels, or proportion of patients in remission. Disease worsening rates were 14.0% for CD and 13.8% for UC; and 2.7% developed ADAbs and 2.2% developed serious adverse events. Conclusions: This is the largest study of switched IBD patients published to date, and it demonstrates that switching from Remicade to CT-P13 may be done with preserved therapeutic effectiveness and safety in both CD and UC.
The Physiological Impact of Window Murals on Pediatric Patients
Authors: Pearson Michelle , Gaines Kristi , Pati Debajyoti , Colwell Malinda , Motheral Leslie , Adams Nicole Gilinsky 
Published: October 2018

Objectives: To examine the magnitude of impact of two nature-themed window murals on physiological processes, as measured by heart rate and blood pressure, of pediatric patients. Background: Many children and adolescents find at least one aspect of the hospitalization process frightening or anxiety provoking. One physical feature linked to stress reduction is access to positive distractions. Views of nature are one of the most common forms of positive distractions in healthcare environments. Patient room windows are the most common way patients are exposed to natural elements. Exposure to views of nature is linked to a number of positive impacts on physiological outcomes. Unfortunately, not every patient room will be able to provide a nature-filled window view. In situations where nature scenes do not occur, enhanced nature views may be utilized to replicate many of the same benefits as actual nature views. Methods: Pediatric patients were randomly assigned to one of the three room conditions: aquatic window mural, tree window mural, or control condition. The medical data of participants ( n = 90) who stayed in the rooms were gathered and evaluated for differences. Results: Data analysis supports the notion that patient stress is heightened at the time of admission. Patients in the rooms with murals were found to have improvements in heart rate and systolic blood pressure in comparison to patients in control rooms, suggesting that the murals had an impact on physiological processes. Data also suggest that subject matter played a role, as patients in tree murals rooms had the most health-related outcomes.
The Benefit of Minced Cartilage Over Isolated Chondrocytes in Atelocollagen Gel on Chondrocyte Proliferation and Migration
Authors: Tsuyuguchi Yusuke , Nakasa Tomoyuki , Ishikawa Masakazu , Miyaki Shigeru , Matsushita Ryosuke , Kanemitsu Munekazu , Adachi Nobuo 
Published: October 2018

Objective Autologous chondrocyte implantation is a necessary procedure for the repair of articular cartilage defects; however, isolated chondrocyte implantation requires a 2-step procedure (for harvesting and implantation) and is limited by cytotoxicity due to enzymatic digestion. Therefore, in this in vitro study, we evaluated the possible benefit of using minced cartilage embedded in a 3-dimensional culture scaffold and fixed with fibrin glue, in comparison with isolated chondrocytes in atelocollagen, to induce cell migration, proliferation, and matrix production, using cartilage from patients with knee joint osteoarthritis. Design Cartilage fragments were obtained from 7 female patients with knee osteoarthritis (OA) and embedded in atelocollagen gels. As a control, chondrocytes were isolated and embedded in gels in the same manner. These composites were cultured for 3 weeks, and cell proliferation and matrix production were evaluated using histology and immunochemistry. Results Histologically, minced cartilage showed cell migration from the cartilage fragments into the gel, with the Bern score and cell count in the minced cartilage group being significantly higher than those in the control group. Immunohistochemistry revealed that the number of Ki67-positive cells, the expression of LECT-1 and TGF-β, and the glycosaminoglycan content were significantly higher in the minced cartilage than in the control group. Minced cartilage exhibited superior cell migration, proliferation, and glycosaminoglycan content than isolated chondrocytes. Conclusion Our findings support that minced cartilage has a favorable potential for cell proliferation and matrix production compared with the isolated chondrocytes after enzymatic treatment.
Navigating medically complex patients through system barriers: Patients’ perspectives on care coordination
Authors: Siañez Monica , Pennel Cara , Tamayo Loida , Wells Rebecca 
Published: October 2018

Introduction Care coordination can improve healthcare quality and reduce costs. The objective of this study was to provide a qualitative understanding of the most helpful coordination services as experienced by patients receiving these services to reduce emergent hospital use. Methods Using case study methodology, we conducted focus group conversations with 51 care coordination patients and semi-structured interviews with 29 care coordinators at nine sites throughout Texas. The study team performed constant comparative analysis, beginning with start codes based on prior research. Results On average, focus group participants were 47 years old. The majority of participants reported a high school or General Equivalency Diploma level of education or less (84%), an annual income less than $14,999 (87%), and living with multiple chronic health conditions (60%). The majority (85%) of care coordinators reported backgrounds in nursing or social work. In our analysis, themes of what patients found most helpful fell under a broad social support framework (instrumental, informational, emotional, and advocacy) that care coordinators were uniquely situated to provide. Discussion Our paper adds to existing evidence by providing perspectives of patients with complex medical and non-medical needs about which care coordination services are most helpful. In this sample, patients with high needs describe reliance on professional sources, rather than their own social networks, to address several aspects of social support and to help meet non-health-related, as well as health-related needs. This can inform providers’ approaches to treatment as well as program administrators’ decisions about addressing and prioritizing services in care coordination programs.