bluuebunny/crossref_metadata_2025_split huggingface dataset:
Meta-analysis and network pharmacology studies of the clinical efficacy of Guizhi Fuling capsules/pills combined with dienogest in treating endometriosis
Authors: Qin Yajie , Yang Xiaotian , Zhao Qi , Tang Xingran , Zhao Huijin , Jiao Yang , Zhou Huifang 
Published: December 2024

Background:
Endometriosis (EMs) is a common chronic inflammatory gynecological disease that belongs to the classification of Traditional Chinese Medicine Syndromes “Zheng Jia,” and the classic Chinese formula Guizhi Fuling (GZFL) demonstrates significant clinical efficacy in the treatment of this condition. This study aims to investigate GZFL’s effect and potential mechanism in EMs.

Methods:
The search reviewed randomized controlled trials in 7 databases from inception to 2024, assessed quality with the Cochrane tool, and analyzed data with STATA 15 by 2 reviewers. In the network pharmacology study, we searched and screened the components and targets of GZFL, subsequently compared these targets to EMs targets, and used bioinformatics techniques to analyze and explore their potential interactions.

Results:
Nine randomized controlled trials involving 897 participants were analyzed. Meta-analysis showed that GZFL combined with dienogest significantly enhanced the clinical effectiveness rate (odds ratio = 2.404, 95% confidence intervals [CI], 1.868 to 3.093; P < .001). Specifically, combination therapy with GZFL reduced serum carbohydrate antigen 125 (standardized mean differences [SMD] = −1.65, 95% CI = −2.13 to −1.17, P < .001), estradiol (SMD = −1.54, 95% CI = −1.89 to −1.19, P = .003), matrix metalloproteinases (SMD = −2.636, 95% CI = −2.993 to −2.279, P < .001), pain scores (SMD = −0.88, 95% CI = −1.11 to −0.67, P < .001) and the diameter of ectopic cysts (SMD = −1.7, 95% CI = −2.42 to −0.98, P < .001). Network pharmacology analysis identified 136 components and 145 common targets, focusing on interleukin-6, cellular tumor antigen p53, epidermal growth factor receptor, estrogen receptor alpha, Cyclooxygenase-2, and matrix metalloproteinases-9. Gene ontology and Kyoto Encyclopedia of Genes and Genomes analyses suggested GZFL modulates hormone receptors and inflammatory responses in EMs treatment.

Conclusion:
In conclusion, GZFL combination treatment could increase the clinical effectiveness rate of EMs patients, and reduce the serum level of carbohydrate antigen 125, estradiol, matrix metalloproteinases, pain scores, and the diameter of the ectopic cyst. The potential mechanism might be linked to the modulation of hormone receptors and inflammation.
Calcifediol and paricalcitol as adjunctive therapies for HSV-1 keratitis and corneal perforation: A case report
Authors: Nemet Vedran , Matić Suzana , Zielsdorf Sarah J. , Tolj Ivana , Jelić Vuković Marija , Švitek Luka , Kalauz Miro , Strunje Ivana , Matić Lucija , Heffer Marija 
Published: December 2024

Rationale:
Herpes simplex virus 1 establishes a latent infection in trigeminal ganglia. Reactivation causes cold sores, as well as viral keratitis. The purpose of this study was to report potential benefits of using active vitamin D receptor ligands (VDR-agonists) as adjunctive therapies for the treatment of infectious corneal perforations, and prevention of HSV recurrence.

Patient concerns:
A 57-year-old female with a past history of episodic, poorly-healing, corneal erosions, recurring orolabial herpetic lesions, as well as PCR-confirmed recurrences of herpes simplex keratitis presented with a burning sensation and slight pain in the right eye. Examination indicated HSV keratitis. Topical antibiotic and oral antiviral treatments were prescribed. Despite these standard-of-care treatments, a perforated corneal ulcer ensued.

Diagnoses:
Corneal perforation associated with HSV-1 keratitis recurrence, later confirmed by PCR analysis of corneal scrapings.

Interventions:
Corneal perforation was treated with a human fibrin glue, fortified with multilayered amniotic membrane transplant, as well as a therapeutical contact lens. Following surgery, calcifediol and paricalcitol were started as oral adjunctive therapies in an attempt to boost tissue regeneration and innate-immunity within the slow-healing cornea. Anterior segment optical-coherence tomography was used to measure corneal thickness. Frequent follow-ups with various specialists allowed for comprehensive patient evaluation, and meticulous screening for any signs indicating potential HSV-1 recurrence.

Outcomes:
Following calcifediol-paricalcitol therapy corneal thickening, and re-epithelization ensued. During combined calcifediol-paricalcitol therapy, the patient has had no recurrence of herpes simplex keratitis, or orolabial herpes lesions.

Lessons:
Corneal stabilization avoided a high-risk, full-thickness corneal transplantation, facilitating future cataract surgery, and allowing for some degree of visual recovery in this eye.
Research hotspots and trends in the treatment of postoperative pain with ropivacaine: A bibliometric analysis from 2003 to 2022
Authors: Yin Bin , Wang Hexiang , Zhao Xiaoming , Zhang Liwen , Yu Yuanyuan 
Published: December 2024

Background:
The aim of this study is to explore the current study status and progression of the effects of ropivacaine in local analgesia by using bibliometric methods.

Methods:
Published articles related to the treatment of postoperative pain with ropivacaine from 2003 to 2022 were retrieved from the Web of Science database. Detailed information such as authors, keywords, journals, countries, institutions and references were analyzed by bibliometric methods and visualized by VOSviewer.

Results:
A total of 1150 articles published in the treatment of postoperative pain with ropivacaine were included in the bibliometric analysis. From 2003 to 2022, the number of articles was on the rise and increased rapidly after 2018. The United States published the highest number of articles and Ilfeld ranked first in the number of papers (35) and citation frequency (1670). Journal of Anesthesiology had the highest average number of citations per article (89.43). There is a close cooperation among countries especially centering China and the United States at their core, universities are the main institutions in publishing articles. The most cited literature was published by Knudsen whose study major in finding out the effects of ropivacaine and bupivacaine to the central nervous system. Among the top 10 high frequency keywords, ropirvacaine and postoperative anesthesia appeared most frequently.

Conclusion:
The application of ropivacaine to postoperative anesthesia attracts growing interest from the scholars all over the world and was the future research hotspot in treating postoperative pain.
Efficacy and safety of QingReJieDu therapy in preventing acute radiation esophagitis: A systematic review and meta-analysis
Authors: Wang Jian , Qiu Dan , Dong Xinying , Liu Yangxin , Chen Jianxin 
Published: December 2024

Background:
Acute radiation esophagitis (ARE) is a frequently observed complication of radiotherapy for malignant tumors. QingReJieDu (QRJD) therapy is commonly used for the prevention and treatment of ARE. There is a lack of evidence regarding the effectiveness and safety of traditional Chinese medicine in preventing ARE. Therefore, the objective of this study was to comprehensively evaluate the efficacy and safety of QRJD therapy in preventing ARE.

Methods:
Systematic searches were conducted across 8 databases from their inception to December 30, 2023. This study included randomized controlled trials that assessed the effectiveness of QRJD therapy in preventing ARE. The methodological quality of the included studies was evaluated using the Cochrane collaboration tool. Data analysis was conducted using RevMan 5.3 and Stata 15.

Results:
Eleven randomized controlled studies involving 754 participants were included in this analysis. The results demonstrated that QRJD therapy effectively prevented the occurrence of ARE (relative risk = 0.84, 95% CI: 0.80–0.89, P < .001), as well as the development of grade ≥ 3 ARE (relative risk = 0.41, 95% CI: 0.28–0.59, P < .001). Furthermore, QRJD therapy delayed the time of the first episode of ARE (weighted mean difference = 5.67, 95% CI: 5.33–6.02, P < .001). No significant increase in adverse events was observed with the QRJD therapy.

Conclusion:
Our results indicate that QRJD therapy has a significant preventive effect on ARE in clinical practice. However, it is important to note that these findings should be confirmed through more rigorously designed, multicenter, large-sample, and large-scale randomized controlled trials.
Efficacy of generic versus branded diacerein for treatment of knee osteoarthritis: A randomized control trial
Authors: Jaruthien Nonn , Tanavalee Aree , Ngarmukos Srihatach , Tanavalee Chotetawan , Amarase Chavarin , Somrak Pakpoom 
Published: December 2024

Background:
Several studies have proved that diacerein effectively treats knee osteoarthritis (OA). All studies used branded diacerein. Recently, generic diacerein has been available in several countries, with limited studies comparing the efficacy of generic and branded diacerein for knee OA treatment.

Methods:
Among 200 eligible patients, 94 were randomized to take a daily 50 mg of generic diacerein (Diaceric®); group A or branded diacerein (Artrodar®); group B for treating mild to moderate knee OA. All patients were assigned 5-visit assessments and followed until 24 weeks. The primary outcome was a visual analog scale (VAS) on the motion. The secondary outcomes were 2 patient-report outcome measures (PROMs): the Western Ontario and McMaster Universities Osteoarthritis (WOMAC) index and the Short Form-12 (SF-12), as well as 3 performance-based measures (PBMs): 5-time sit to stand test (5 × SST), the time up and go test (TUGT), and the 3-minute walk test (3MWT).

Results:
There were 47 patients in group A and 47 in group B, with no patients lost for FU. Among all patients, 79.8% were female with a mean age of 63.2 years in group A and 64.8 years in group B. The Kellgren and Lawrence (KL) grade II was the most common in both groups. There were no differences in all demographic data. At 24-week follow-up (FU), both groups had significantly improved VAS, with a 12-week earlier improvement in the branded diacerein. In addition, the PBMs, including 5 × SST and 3MWT, significantly improved from 12-week FU in both groups, with insignificantly improved WOMAC and SF-12 and no serious adverse events in either group.

Conclusion:
After a 24-week FU, the generic diacerein had similar efficacy as the branded diacerein in significantly improving VAS and PBMs: 5 × SST and 3MWT. However, the latter had a faster statistically improved VAS than the former.
Hypertrophic pachymeningitis with cranial nerve palsy as the initial symptom: A case report
Authors: Zhang Xin 
Published: December 2024

Rationale:
Hypertrophic pachymeningitis (HP) is a rare and complex condition marked by inflammation and thickening of the dura mater. It can occur either on its own or as a result of various underlying medical issues. This type of granulomatous meningitis is extremely rare and poorly understood, making diagnosis and treatment particularly challenging. Patients with HP may experience severe headaches and cranial nerve defects, but in some cases, the condition can occur without any symptoms, making it undetected. We detail the case of patient who was diagnosed with HP after presenting with abducens nerve palsy, a condition that significantly affected her vision and quality of life. Remarkably, she showed substantial recovery following a course of methylprednisolone pulse therapy, coupled with careful radiographic diagnosis and follow-up assessments. The decision to report this case stems from its rarity and the diverse clinical manifestations associated with this condition, which can vary widely among patients.

Patient concerns:
A 26-year-old Asian female, sought medical attention at The First Affiliated Hospital of Zhejiang Chinese Medical University, where she reported experiencing diplopia, a troubling symptom indicative of abducens nerve palsy.

Diagnosis:
To establish a definitive diagnosis, second-generation sequencing biological detection was employed to rule out any infectious causes, while radiographic imaging provided confirmation of HP.

Interventions:
In terms of intervention, the patient was promptly initiated on a regimen of methylprednisolone pulse therapy, followed by a carefully monitored oral sequential reduction of the medication. Throughout her treatment, she underwent regular liver function tests to ensure her safety, and liver protective drugs were also administered as a precautionary measure.

Outcomes:
As of now, the patient has successfully completed her treatment and is reported to be doing well, marking a positive outcome in her recovery journey.

Lessons:
This case underscores the critical importance of imaging examinations in the clinical diagnosis of patients presenting with diplopia, as they play a vital role in both diagnosing and differentiating between various diseases. Furthermore, it is essential to rule out any infection-related factors in patients diagnosed with HP before commencing treatment with glucocorticoids, ensuring a comprehensive approach to patient care.
Study on the influencing factors of primary dysmenorrhea in female college students: Systematic review and meta-analysis
Authors: Liu Jingyu , Wang Yimu , Wu Lingsha , Wang Lingyu , Fang Haiyan 
Published: December 2024

Background:
The influencing factors of primary dysmenorrhea in female college students were analyzed through meta-analysis to provide the corresponding basis for its prevention and treatment.

Methods:
The databases, including China National Knowledge Infrastructure, Wanfang Data Knowledge Service Platform, VIP database, China Biology Medicine Disc, Pubmed, Embase, Cochrane library, and Web of science were searched for the literature on the influencing factors of primary dysmenorrhea in female college students was retrieved from the science database from the establishment of the database to July 17, 2023. The Newcastle-Ottawa Quality Scale was used to score the quality of cohort and case–control studies included in the study. The cross-sectional studies were scored by the Agency for Healthcare Research and Quality. Two researchers independently screened the literature, and if there was no consensus, the third party would make a judgment on whether to include the literature. The extracted content included the first author, publication year, country, study type, sample size, and influencing factors. Stata17.0 software was used for meta-analysis.

Results:
A total of 23 studies were included, with a total sample size of 18,080 cases. Current evidence shows that the prevalence of primary dysmenorrhea in female college students is 70.3% (95%CI: 62.7–77.9%), and the combined odd ratio values (95%CI) of the main influencing factors are: family history of dysmenorrhea 2.116 (1.613–2.776), early age at menarche 2.200 (1.392–3.477), irregular menstrual cycle 1.662 (1.166–2.367), drinking cold drinks 1.717 (1.220–2.417), high caffeine intake 2.082 (1.379–3.144), stress 1.895 (1.515–2.282), medical specialty 1.827 (1.365–2.445), and adequate sleep 0.328 (0.232–0.463).

Conclusion:
The prevalence of primary dysmenorrhea is high in female college students, and adequate sleep is a protective factor for primary dysmenorrhea. Family history of dysmenorrhea, early age at menarche, irregular menstrual cycle, drinking cold drinks, high caffeine intake, stress, and medical specialty were all risk factors.
Breaking the Cycle of Nurse Manager Presenteeism
Authors: Bethel Claire , McIntosh Caitlin , Rainbow Jessica G. 
Published: December 2024

OBJECTIVE
The aim was to describe the factors leading to, and explore the coping strategies and the consequences of, nurse manager presenteeism

BACKGROUND
Presenteeism, or presence at work while not fully performing, is prevalent among direct-care nurses, yet no studies have explored nurse manager presenteeism.

METHODS
This study used a convergent mixed-methods design with 1:1 interviews, a demographic questionnaire, mental/physical health and work situation questions, and the Job Stress–Related Presenteeism Scale (JSPS). Participants included 14 nurse managers from 3 hospitals in Central Pennsylvania.

FINDINGS
Quantitative results reveal participants' physical and mental health, results of the JSPS, and inferences between presenteeism and health/demographic items. The overarching qualitative theme was the cyclic nature of presenteeism. Work demands and other contributing factors, like illness and personal factors, contribute to presenteeism, which leads to adverse consequences. The consequences lead to more work demands and can lead the nurse manager to consider leaving a job or the profession. The cycle can be broken by protective factors, coping mechanisms, and support. Mixed-methods results revealed convergence among the quantitative and qualitative results.

CONCLUSIONS
Executive leaders must help nurse managers break the cycle of nurse manager presenteeism. Nurse managers need fewer work demands and more support to improve their performance at work.
Point-of-Care Ultrasound in the Expedient Identification and Management of Hydropneumothorax Secondary to Necrotizing Pneumonia
Authors: Cramer Natan , Philip Vipin , Azhdam Devora Bita 
Published: December 2024

Abstract
We report the use of point-of-care ultrasound to identify a hydropneumothorax in a 6-year-old previously healthy girl arriving at the emergency department in severe respiratory distress. The use of point-of-care ultrasound in this instance allowed for the expedient management and stabilization of the hydropneumothorax with emergent thoracentesis. The patient was ultimately found to have Streptococcus pyogenes bacteremia and necrotizing pneumonia.
68Ga-DOTATATE PET/CT Demonstrated More Lesions of Leptomeningeal Metastases Compared With 123I-MIBG SPECT/CT in a Pediatric Neuroblastoma Patient
Authors: Zheng Lingling , Li Siqi , Xu Yanfeng , Wang Wei , Yang Jigang 
Published: December 2024

Abstract
A 5-year-old girl with high-risk neuroblastoma after therapy was evaluated by 123I-MIBG SPECT/CT and 68Ga-DOTATATE PET/CT. Contrast-enhancement brain MRI demonstrated 2 metastatic lesions in the right parietal lobe of brain. One lesion showed abnormal MIBG accumulation associated with high density in the right central posterior gyrus, whereas the other lesion did not show MIBG uptake. In contrast, increased 68Ga-DOTATATE uptake was seen in both lesions. Neuroblastoma cells were found by cytological examination of the cerebrospinal fluid.
Clinical Response to Electroconvulsive Therapy in a Young Adult With Down Syndrome Regression Disorder
Authors: Kelley Brendan J. , Bailey Kala J. , Hubregsen Joshua J. 
Published: December 2024

Abstract
Down syndrome regression disorder (DSRD) is a condition in which individuals with Down syndrome experience a decline in social and adaptive functioning in adolescence to early adulthood. Initially described as catatonic psychosis and later designated Down syndrome disintegrative disorder (DSDD), the etiology for DSRD remains unclear but has been hypothesized to relate to autoimmune function, stress, and psychiatric disease. DSRD presents heterogeneously and has no clearly established diagnostic criteria, which can complicate treatment recommendations. ECT has been used to successfully treat DSRD, but the number of reported cases remains low, especially when it is unclear whether there are comorbid catatonic features. Here, we present a case of successful use of ECT in an individual with DSRD in which catatonic features were difficult to ascertain, and we make recommendations for the use of ECT in the treatment of DSRD.
Lipid-based nanoparticles deliver mRNA to reverse the pathogenesis of lysosomal acid lipase deficiency in a preclinical model
Authors: Zadory Matthias , Lopez-Vince Elliot , Haddouch Hamza , Babity Samuel , Rezaei Nastaran , Moawad Fatma , El Rahbani Rita Maria Kenaan , Vujic Nemanja , Trinh Vincent Q. , Kratky Dagmar , Gravel Simon-Pierre , Brambilla Davide 
Published: December 2024

AbstractLysosomal acid lipase (LAL) is the only known enzyme that degrades cholesteryl esters (CEs) and triglycerides (TGs) in the lysosomes. LAL deficiency (LAL-D) results in hepatosplenomegaly with extensive accumulation of CEs and TGs, and can in the most severe cases be a life-threatening condition in early infancy. Using messenger ribonucleic acid (mRNA) for protein replacement is an innovative approach for the treatment of genetic disorders, but is challenged by a safe and efficient mRNA delivery. Here, we generated a combinatorial library of lipid-based nanoparticles (LNPs) for mRNA delivery and screened itin vitroandin vivo,which yielded a new formulation with a superior potency than an FDA-approved nanoformulation. This formulation efficiently delivered LAL mRNA and restored LAL activity in liver and spleen, mediating significant reversal of the pathological progression in an aggressive preclinical model of LAL-D.In vivo,the new formulation also promoted a more sustained and quantitatively higher LAL expression. In addition, repeated administration regimen mitigated hepatosplenomegaly, and targeted lipidomic analysis revealed strong diminution of CEs and TGs and of toxic lipid species in the liver and spleen. Transcriptomic analysis showed significant attenuation of inflammatory processes, fibrosis and several pathological pathways associated to LAL-D. These findings provide strong evidence that the intracellular production of LAL via mRNA-LNP is a very promising approach for the chronic treatment of LAL-D and support the clinical translation of mRNA therapy to overcome the challenges associated with traditional enzyme replacement therapies.One Sentence SummaryScreening of a mRNA-LNPs library yielded a formulation with outmost potency and mitigated the progression of LAL deficiency in a preclinical model.
Can remotely-sensed vegetation health indices increase the hedging-effectiveness of index insurance? – Insights from Germany
Authors: Nordmeyer Eike Florenz , Musshoff Oliver 
Published: December 2024

PurposeSatellite-retrieved vegetation health (VH) indices are under active consideration to be integrated into weather index insurance to reduce the basis risk and increase the attractiveness to farmers. The objective of this study is to obtain a deeper understanding of the hedging effectiveness (HE) of the satellite-retrieved VH indices.Design/methodology/approachBy using winter wheat yield records from 79 farms in Northern and Eastern Germany over 20 years, we designed index insurance based on three satellite indices to explore their HE: the Vegetation Condition Index (VCI), the Temperature Condition Index (TCI) and the Vegetation Health Index (VHI) with a spatial resolution of 1 × 1 km. As the benchmark, a meteorological index related to precipitation is employed.FindingsThe results indicate that, on average, the TCI and VHI outperform the benchmark index in a statistically significant way. However, considerable differences across regions are observed. In particular, the highest HE, and therefore basis risk reduction, was found for regions with sandy soils in Eastern Germany.Practical implicationsInsurers can be advised to accelerate the research and development of satellite-based index insurance in Eastern Germany. By considering our insurance design, products with low transaction costs and therefore comparatively low loading factors can be offered to farmers.Originality/valueTo the best of our knowledge, this is the first study that uses a large sample to explore the HE of index insurance based on satellite-retrieved VH indices by focusing on different regions in a country.