bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dancing in Tandem: The Role of HR Value Congruence and Line Manager‐HR Manager Collaboration in Effective HR Implementation
Authors: Zhang Zhengtang , Lee Hun Whee , Jiang Kaifeng , Chen Yuyao 
Published: December 2024

ABSTRACTDespite the increasing significance of partnerships between line managers and human resource managers in implementing HR practices, prior research has overlooked the potential interplay between these two groups in terms of collaboration and line managers' subsequent HR implementation behavior. By integrating insights from value congruence theory and social context theory, we formulated a model that examines how congruence or incongruence in HR values between line managers and HR managers influences line managers' HR implementation behaviors through their collaboration. We tested our hypotheses using multi‐source and multi‐wave data from 206 stores within a large retail chain organization (206 line managers, 206 HR managers, and 1227 employees). The polynomial regression results revealed that optimal collaboration and line managers' HR implementation behaviors occur when both parties agree on HR value, while disagreement negatively impacts these aspects. Moreover, we observed significant differences between the two levels of agreement (i.e., “high–high” congruence vs. “low–low” congruence). We further found that HR managers' political skill moderates the relationship between incongruence in HR value and collaboration levels. This research advances the understanding of HR implementation by emphasizing the importance of mutual agreement between line managers and HR managers and the role of HR managers' political skill.
Unveiling Student Suicides in the Post‐Pandemic Period: A Retrospective Analysis of Online News Portals in Bangladesh
Authors: Himel Mahfujur Rahman , Siyam Samira Akter , Tanni Jannatunnahar , Rafiquzzaman SK , Alam Md Jane , Hassan Md Bayzid , Uddin Md Jamal 
Published: December 2024

ABSTRACTBackground and AimsThe post‐COVID‐19 pandemic period has heightened concerns about student mental health and suicide risk in Bangladesh. While studies have explored these issues during the pandemic, post‐pandemic student suicides remain under‐researched. This study investigates the characteristics, methods, and triggering events associated with suicidal behaviors among students in Bangladesh during the post‐pandemic period (2022–2023).MethodsData were collected from 150 online newspaper portals in Bangladesh, covering student suicides from 2022 to 2023. Variables such as causes, methods, timing, location, sex, age, and education level were analyzed using Microsoft Excel, SPSS, and ArcGIS.ResultsA total of 984 student suicide cases were identified. Females accounted for 61% of the cases, while males represented 39%, indicating a higher vulnerability among female students. The majority of cases (72.5%) involved students aged 13–19 years, followed by those aged 20–25 years (18.4%). Secondary school students represented 44.9% of the cases, with 7.2% from madrasahs. Hanging was the most common method (79.7%). Major causes included emotional distress (28%), romantic relationship issues (19.5%), academic pressure (8.4%), family problems (8.1%), mental instability (7%), and sexual harassment (3.3%). The Dhaka division reported the highest rate (27.8%) of student suicides. Suicide rates were lowest in August 2022 (4.3%) but spiked in 2023 (12.6%).ConclusionThis study highlights the significant rise in student suicides in Bangladesh after the pandemic, primarily driven by emotional distress, with females and the 13–19‐year age group being most vulnerable. These findings emphasize the urgent need for gender‐specific mental health interventions to address this growing issue.
Risk Evaluation and Mitigation Strategies for Potential Outbreaks of Nipah Virus Infection: Evidenced by the Recent Incidences in Southeast Asian Countries
Authors: Rahman Md. Ashrafur , Shanjana Yeasna , Cronmiller Sydney , Zong Donovan , Davis Rob , Ernest Julianne , Nguyen Jonah , Rawa Amanda , Thomas Marie Roke , Islam Md. Rabiul 
Published: December 2024

ABSTRACTBackgroundThe importance of studying Nipah virus (NiV) stems from its high fatality rates and potential for causing widespread outbreaks. Recent incidences in Southeast Asian countries highlight the urgent need for effective risk evaluation and mitigation strategies.JustificationStudying NiV in Southeast Asia is crucial due to the geographic and epidemiological significance that makes this region predominantly susceptible to the virus.ObjectivesThis study aims to identify the risk factors of NiV, evaluate current mitigation strategies, and suggest improvements against this virus.MethodsThis review incorporates articles from the PubMed database related to available NiV treatments, vaccines, mitigation strategies, transmission data, and mortality to comprise an extensive analysis of pertinent information.FindingsNiV warrants international attention, due to the high mortality rate and the rising number of human‐to‐human transmission vectors. NiV is difficult to diagnose early on in the infection due to its generic symptoms, and the two strains of NiV (B and M), pose significant challenges to healthcare institutions. Vaccines, such as the VSV‐stored, virus‐like particle‐based, and mRNA‐based NiV show promising results in both animal and human studies. Synthetic medicines, like Ribavirin, and favipiravir showed promising results in NiV‐infected patients. Therapeutic infectious particles increased survival from 10% to roughly 70%–80% in animals. Phytochemicals, like serpentine and neoandrographolide are alternatives to NiV‐G ligands. Griffithsin, an algae derivative has also shown efficacy in treating NiV infections. Artificial intelligence determines the NiV infection with an accuracy of 88.3%.ConclusionsThe strategies to control NiV must be one of a One Health approach, incorporating environmental and social factors. Extensive research on vaccines that showed promising results in animals needs to be tested for humans on a large scale. The major mitigation strategy available is the public awareness during the outbreak about NiV transmission vectors, quarantine protocol, and food hygiene.
NMR‐based metabolomics combined with metabolic pathway analysis reveals metabolic heterogeneity of colorectal cancer tissue at different anatomical locations and stages
Authors: Cai Rongzhi , Ke LiXin , Zhao Yan , Zhao Jiayun , Zhang Huanian , Zheng Peie , Xin Lijing , Ma Changchun , Lin Yan 
Published: December 2024

AbstractColorectal cancer (CRC) still remains the leading cause of cancer death worldwide. This study aimed to profile the metabolic differences of colorectal cancer tissues (CCT) at different stages and sites, as compared with their distant noncancerous tissues (DNT), to investigate the temporal and spatial heterogeneities of metabolic characterization. Our NMR‐based metabolomics fingerprinting revealed that many of the metabolite levels were significantly altered in CCT compared to DNT and esophageal cancer tissues, indicating deregulations of glucose metabolism, one‐carbon metabolism, glutamine metabolism, amino acid metabolism, fatty acid metabolism, TCA cycle, choline metabolism, and so forth. A total of five biomarker metabolites, including glucose, glutamate, alanine, valine and histidine, were identified to distinguish between early and advanced stages of CCT. Metabolites that distinguish the different anatomical sites of CCT include glucose, glycerol, glutamine, inositol, succinate, and citrate. Those significant metabolic differences in CRC tissues at different pathological stages and sites suggested temporal and spatial heterogeneities of metabolic characterization in CCT, providing a metabolic foundation for further study on biofluid metabolism in CRC early detection.
Yield of endocervical curettage in detecting cervical intraepithelial neoplasia grade 2 or higher during colposcopy: A prospective, cross‐sectional study
Authors: Jareemit Nida , Theerarojanapong Lalita , Laokulrath Natthawadee , Achariyapota Vuthinun , Khemworapong Khemanat , Kuljarasnont Sompop , Ittiamornlert Pornporm , Poonyakanok Vitcha , Inthasorn Perapong 
Published: December 2024

AbstractObjectiveThis study assessed the prevalence and factors associated with detecting cervical intraepithelial neoplasia grade 2 or higher (CIN2+) via endocervical curettage (ECC) during colposcopy.MethodsBetween December 2020 and September 2023, a prospective, cross‐sectional study involving women with abnormal cervical cancer screening results who underwent colposcopy was conducted. ECC was performed via a Kevorkian endocervical curette following colposcopy‐directed biopsy. The exclusion criteria were glandular cytology abnormalities, pregnancy, post‐hysterectomy status, and cervical cancer.ResultsThe study included 569 women, with a mean age of 41.6 ± 11.7 years. Among the participants, 78.9% presented with low‐grade cytology, whereas 21.1% presented with high‐grade cytology. All of the patients underwent ECC, with 0.4% (two patients) yielding inadequate samples. ECC detected CIN2+ lesions in 11.6% of the patients (95% confidence interval [CI], 9–14.3). Univariable analysis revealed that age, menopausal status, history of CIN2+, high‐grade cytology, and high‐grade colposcopy impression were significant factors for CIN2+ detection by ECC. Multivariable analysis confirmed high‐grade cytology as the sole independent factor (adjusted odds ratio [OR], 13.81 [95% CI, 4.60–41.42], P < 0.001). ECC added a diagnostic yield of 2.9% (95% CI, 1.5–4.3) for detecting CIN2+ lesions missed by colposcopy‐directed biopsy. Multivariable analysis demonstrated an independent association between human papillomavirus 16 (HPV‐16) infection and the additional diagnostic benefit of ECC, with an adjusted odds ratio (OR) of 6.26 (95% CI, 1.49–26.23, P = 0.012).ConclusionThis study highlights the critical role of ECC in detecting CIN2+ lesions, particularly in patients with high‐grade cytology or HPV‐16 positivity.
Experiences of childbirth care among mothers in Lithuania during COVID‐19
Authors: Širvinskienė Giedrė , Norė Aušra , Grincevičius Jonas , Grincevičienė Švitrigailė 
Published: December 2024

AbstractThe COVID‐19 pandemic affected healthcare practices, especially the provision of face‐to‐face services due to restrictions and social distance. The aim of the study was to analyze the experience of childbirth care among mothers in Lithuania during the pandemic. A qualitative design was adopted in the study. Research data were collected as part of the international Babies Born Better survey. Data of 200 women who gave birth in Lithuania (February–June 2020 during the COVID‐19 pandemic) was included. Participant responses to open‐ended questions regarding childbirth care experiences were analyzed using an inductive thematic framework. Four themes emerged: “Subjective experience of birth care service,” “COVID‐19 policies,” “Consideration of mother/baby needs,” and “Perception towards staff.” Emotional aspects of different care levels were highlighted in themes. Women expressed feelings of thankfulness for staff professionality and responding to their needs. However, perceived staff rudeness, lack of information and absence of an accompanied person negatively related to mothers’ perceptions of satisfaction. The results revealed mothers’ perceptions of strengths and challenges of the maternity care system in the country where the pandemic was managed with early vaccination, strict lockdown measures and social distancing—higher appreciation of service, regret for disturbed emotional aspects of communication, and lack of support from family members.
Comparison of two infiltration equations with three‐terms expansions consistent with the approach of Philip theory
Authors: Kargas George , Koka Dimitrios , Londra Paraskevi A. , Mindrinos Leonidas 
Published: December 2024

AbstractIn this study, the approximate three‐term (3 T) one‐dimensional (1D) vertical infiltration equation by Valiantzas (3 T‐V) and the 3 T approximate infiltration equation of the quasi‐exact implicit (QEI) Haverkamp equation (3T‐R) by Rahmati et al. for both direct and inverse modelling of water infiltration into soils were evaluated. The 3 T‐V equation is simpler and involves only two physically meaningful parameters, sorptivity (S) and saturated hydraulic conductivity (Ks), unlike 3 T‐R, which includes an additional parameter, β. The coefficients of the second and third terms of 3 T‐V acquire the same values as those of 3 T‐R for values of the parameter β equal to 0.6 and 1.1, respectively. Both 3 T equations yielded similar cumulative infiltration results except at longer times. The inverse solution of 3 T‐V showed better accuracy in predicting S and Ks, with relative error (RE) values generally below 6% and 11%, respectively. The reliability of the S and Ks predictions via the 3 T equations improved over time, and both methods yielded nearly identical results across the studied soils at all infiltration times. However, longer times are needed to accurately predict Ks. Analysing the contribution of each term reveals that the third term (t3/2), though minor in total infiltration, extends the validity time of the 3 T equations.
Transition to Piscivory Seen Through Brain Transcriptomics in a Juvenile Percid Fish: Complex Interplay of Differential Gene Transcription, Alternative Splicing, and ncRNA Activity
Authors: Symonová Radka , Jůza Tomáš , Tesfaye Million , Brabec Marek , Bartoň Daniel , Blabolil Petr , Draštík Vladislav , Kočvara Luboš , Muška Milan , Prchalová Marie , Říha Milan , Šmejkal Marek , Souza Allan T. , Sajdlová Zuzana , Tušer Michal , Vašek Mojmír , Skubic Cene , Brabec Jakub , Kubečka Jan 
Published: December 2024

ABSTRACTPikeperch (Sander Lucioperca) belongs to main predatory fish species in freshwater bodies throughout Europe playing the key role by reducing planktivorous fish abundance. Two size classes of the young‐of‐the‐year (YOY) pikeperch are known in Europe and North America. Our long‐term fish survey elucidates late‐summer size distribution of YOY pikeperch in the Lipno Reservoir (Czechia) and recognizes two distinct subcohorts: smaller pelagic planktivores heavily outnumber larger demersal piscivores. To explore molecular mechanisms accompanying the switch from planktivory to piscivory, we compared brain transcriptomes of both subcohorts and identified 148 differentially transcribed genes. The pathway enrichment analyses identified the piscivorous phase to be associated with genes involved in collagen and extracellular matrix generation with numerous Gene Ontology (GO), while the planktivorous phase was associated with genes for non‐muscle‐myosins (NMM) with less GO terms. Transcripts further upregulated in planktivores from the periphery of the NMM network were Pmchl, Pomcl, and Pyyb, all involved also in appetite control and producing (an)orexigenic neuropeptides. Noncoding RNAs were upregulated in transcriptomes of planktivores including three transcripts of snoRNA U85. Thirty genes mostly functionally unrelated to those differentially transcribed were alternatively spliced between the subcohorts. Our results indicate planktivores as potentially driven by voracity to initiate the switch to piscivory, while piscivores undergo a dynamic brain development. We propose a spatiotemporal spreading of juvenile development over a longer period and larger spatial scales through developmental plasticity as an adaptation to exploiting all types of resources and decreasing the intraspecific competition.
Domain‐Shuffling in the Evolution of Cyclostomes and Gnathostomes
Authors: Kariyayama Hirofumi , Kawashima Takeshi , Wada Hiroshi , Ozaki Haruka 
Published: December 2024

ABSTRACTVertebrates acquired various novel traits that were pivotal in their morphological evolution. Domain shuffling, rearrangements of functional domains between genes, is a key molecular mechanism in deuterostome evolution. However, comprehensive studies focusing on early vertebrates are lacking. With advancements in genomic studies, the genomes of early vertebrate groups and cyclostomes are now accessible, enabling detailed comparative analysis while considering the timing of gene acquisition during evolution. Here, we compared 22 metazoans, including four cyclostomes, to identify genes containing novel domain architectures acquired via domain‐shuffling (DSO‐Gs), in the common ancestor of vertebrates, gnathostomes, and cyclostomes. We found that DSO‐Gs in the common ancestor of vertebrates were associated with novel vertebrate characteristics and those in the common ancestor of gnathostomes correlated with gnathostome‐specific traits. Notably, several DSO‐Gs acquired in common ancestors of vertebrates have been linked to myelination, a distinct characteristic of gnathostomes. Additionally, in situ hybridization revealed specific expression patterns for the three vertebrate DSO‐Gs in cyclostomes, supporting their potential functions. Our findings highlight the significance of DSO‐Gs in the emergence of novel traits in the common ancestors of vertebrates, gnathostomes, and cyclostomes.
Trauma‐informed practice for genetic counselors: Insights from a workshop evaluation
Authors: Schlub Georgina , De Deckker Kimberley 
Published: December 2024

AbstractTrauma‐informed practice (TIP) is an emerging model of care that acknowledges the widespread impact of trauma and emphasizes both physical and psychological safety for consumer and provider. It is being increasingly integrated into models of healthcare delivery, organizational policies, and practices, and has been shown to improve clinical interactions, increase treatment adherence, and improve healthcare outcomes. However, to date, TIP has not yet been systematically integrated into genetic counseling training and practice. In this study, using the RISE2 Genomics reporting standard, we present the outcomes of developing and evaluating a TIP workshop designed and delivered for genetic counselors in New South Wales, Australia. This workshop was the first of its kind and addressed the unique clinical and psychosocial challenges that genetic counselors face, including the risk of vicarious trauma and the high rates of burnout in the profession. The workshop aimed to enhance genetic counselors' understanding of trauma and its effects, provide practical strategies for communication and engagement with trauma‐affected individuals, and offer guidance on incorporating TIP into clinical practice. Genetic counselors who participated in the TIP training expressed strong appreciation for the workshop and reported increased awareness of the ubiquity of trauma and the presentation of traumatic responses, and increased self‐perceived knowledge and confidence in providing trauma‐informed care. Additionally, participants were interested in ongoing TIP professional development and the integration of TIP into models of genetic counseling and professional practice. As the field of genetic counseling continues to evolve, we suggest that integrating TIP into training, professional development, and practice will not only improve client outcomes but also reduce rates of vicarious trauma and burnout among genetic counselors. This study is the first to consider the educational needs and the incorporation of TIP into genetic counseling practice, and in doing so, it paves the way for future research and policy development that integrates TIP into models of genetic counseling.
TAZ‐hTrap: A Rationally Designed, Disulfide‐Stapled Tead Helical Hairpin Trap to Selectively Capture Hippo Signaling Taz With Potent Antigynecological Tumor Activity
Authors: Tang Bin , Du Yu , Wang Jun 
Published: December 2024

ABSTRACTTranscriptional enhanced associate domain (Tead)–mediated Hippo signaling pathway regulates diverse physiological processes; its dysfunction has been implicated in an increasing number of human gynecological cancers. The transcriptional coactivator with PDZ‐binding motif (Taz) binds to and then activates Tead through forming a three‐helix bundle (THB) at their complex interface. The THB is defined by a double‐helical hairpin from Tead and a single α‐helix from Taz, serving as the key interaction hotspot between Tead and Taz. In the present study, the helical hairpin was derived from Tead protein to generate a hairpin segment, which is a 25‐mer polypeptide consisting of a longer helical arm‐1 and a shorter helical arm‐2 as well as a flexible loop linker between them. Dynamics simulation and energetics characterization revealed that the hairpin peptide is intrinsically disordered when splitting from its protein context, thus incurring a large entropy penalty upon binding to Taz α‐helix. A disulfide bridge was introduced across the two helical arms of hairpin peptide to obtain a strong binder termed TAZ‐hTrap, which can maintain in a considerably structured, native‐like conformation in unbound state, and the entropy penalty was minimized by disulfide stapling to effectively improve its affinity toward the α‐helix. These computational findings can be further substantiated by circular dichroism and fluorescence polarization at molecular level, and viability assay also observed a potent cytotoxic effect on diverse human gynecological tumors at cellular level. In addition, we further demonstrated that the TAZ‐hTrap has a good selectivity for its cognate Taz over other noncognate proteins that share a high conservation with the Taz α‐helix.
Boundary Objects at Play in the World's Greenest Football Club
Authors: Samuel Anthony , White Gareth R. T. , Thomas Robert , McGouran Cathy , Bull Michael 
Published: December 2024

ABSTRACTIn the face of increasing environmental and societal pressures, organizations are gradually moving away from merely reducing their detrimental effects toward making positive impacts. One sizeable sector of economic activity, that is frequently overlooked, is that of sport, of which football is the largest in terms of economic value, fan base and global cultural influence. It is only relatively recently that outliers in the football industry have transitioned from being purely profit‐motivated to being both socially and environmentally aware. This transition is challenging since it is being undertaken within the often aggressively masculine environment, as well as the deep‐seated socio‐historical origins and contexts of the individual clubs and the sport as a whole. One such outlying football club is Forest Green Rovers which appears to have navigated this journey successfully. However, research has yet to understand “how” this has been achieved. This study addresses this gap through a 4‐year examination of the social and environmental initiatives of Forest Green Rovers. This lower‐league “club on the hill” is globally recognized for its novel approaches and solutions. Through examining the various Boundary Objects that aid in uniting disparate social groups in order to effect considerable changes to the “match day experience” and to stakeholders' consumption behaviors, it explains how their pragmatic, syntactic, and semantic functions combine to create an accepted suite of socially and environmentally beneficial initiatives.