bluuebunny/crossref_metadata_2025_split huggingface dataset:
A New Framework for Contextual Multilayer Knowledge Embedding in Large Language Models
Authors: Bennet Michael , Roberts Karen , Whitmore Sebastian , Young Jason 
Published: November 2024

Abstract

The exponential growth of data and the increasing complexity of language understanding tasks require more sophisticated models capable of capturing complex contextual information. Introducing a novel approach termed contextual multilayer knowledge embedding, this methodology enhances large language models through the integration of layered contextual embeddings, thereby improving their performance and adaptability across diverse domains. The proposed framework incorporates a theoretical basis for embedding contextual knowledge across multiple layers, modifications to existing architectures, and comprehensive training protocols. Experimental evaluations demonstrate significant improvements in accuracy, precision, recall, and F1-scores, alongside increased robustness to noisy inputs and efficient scalability across various hardware configurations. These findings demonstrate the potential of contextual multilayer knowledge embedding to advance the capabilities of large language models, offering a promising direction for future research and applications in natural language processing.
ATP-dependent thermoring basis for the heat unfolding of the first nucleotide-binding domain isolated from human CFTR
Authors: Wang Guangyu 
Published: November 2024

Abstract

Traditionally, the thermostability of a protein is defined by a melting temperature, at which half of the protein is unfolded. However, this definition cannot indicate the structural origin of a heat-induced unfolding pathway. Here, the thermoring structures were studied on the ATP-dependent heat-induced unfolding of the first nucleotide-binding domain from the human cystic fibrosis transmembrane conductance regulator. The results showed that initial theoretical and experimental melting thresholds aligned well after three structural perturbations including the F508del mutation, the most common cause of cystic fibrosis. This alignment further demonstrated that the heat-induced unfolding process began with the disruption of the least-stable noncovalent interaction within the biggest thermoring along the single peptide chain. The C-terminal region, which was related to the least-stable noncovalent interaction and the ATP-dependent dimerization of two nucleotide-binding domains, emerged as a crucial determinant of the thermal stability of the isolated protein and a potential interfacial drug target to alleviate the thermal defect caused by the F508del mutation. This groundbreaking discovery significantly advances our understanding of protein activity, thermal stability, and molecular pathology.
On the phylogenetic history of the Sanje mangabey (Cercocebus sanjei)
Authors: Paddock Christina Lynette , Silva Maria Joana Ferreira da , McCabe Gráinne Michelle , Fernández David , McGraw William Scott , Bruford Michael William 
Published: November 2024

Abstract

The Sanje mangabey (Cercocebus sanjei) is an Endangered (IUCN) primate endemic to the Udzungwa Mountains, Tanzania. Two populations, both inhabiting montane forest fragments, have been identified. The phylogenetic position of the Sanje mangabey relative to other Cercocebus species remains unclear and this knowledge gap has important conservation implications. Here, we use sequence data from all recognised Cercocebus species to clarify the phylogeny of the Sanje mangabey and estimate its divergence time from other species. Phylogenies were reconstructed using nuclear (CD4 and TSPY) and mitochondrial (COII and control region) sequences. The Sanje mangabey grouped with the Central/East African mangabeys - C. galeritus, C. chrysogaster, and C. agilis – and is estimated to have diverged from the common ancestor shared with these three species 2.34 million years ago (MYA; 95% HPD interval: 1.73–2.95 MYA). The two extant Sanje mangabey populations represent distinct lineages, diverging 0.77 MYA (95% HPD interval: 0.43–1.15 MYA). This divergence and isolation into two montane forest fragments are attributed to: i) increasing aridification in eastern Africa beginning ~ 2.6 MYA, ii) competition with other species, and iii) the formation of physical barriers to dispersal. This study confirms the evolutionary distinctiveness of the Sanje mangabey and therefore conservation management policies should be considered at the species level and the Sanje mangabey populations managed independently as evolutionarily significant units.
High-Resolution Simulation of CME-CIR Interactions: Small- to Mesoscale Solar Wind Structure Formation Observable by the SWIFT Constellation
Authors: IV Ward Manchester , Sachdeva Nishtha , Kilpua Emilia , Ala-Lahti Matti , Soni Shirs Lata , Huang Zhenguang , Chen Hongfan , Jivani Aniket , Holst Bart van der , Szabo Adam , Akhavan-Tafti Mojtaba 
Published: November 2024

Abstract

Coronal Mass Ejections (CME) are large eruptions of plasma and magnetic fields from the Sun, causing significant disturbances through the heliosphere. Their internal structure and complexity are yet unresolved due lack of suitable observations and simulations. We present the results of a high- resolution simulation capable for the first time of capturing the formation and evolution of small- to mesoscale structures in a CME demonstrating significant increases in complexity. These structures dynamically form in our simulation initialized using the solar maximum conditions of September 2014 in which the heliospheric current sheet is vertically inclined running over the poles and where the CME interacts with a preceding slow-fast stream interaction region. The simulation of this interaction is performed with the Alfv ́en Wave Solar Atmosphere Model (AWSoM). With AWSoM, we first produce the background solar wind condition using a synoptic magnetic field map for Carrington Rotation 2154. The CME is initiated from active region (AR) 12158 applying a Gibson-Low magnetic flux rope with parameters to produce a fast CME. With the use of high-resolution grids, we capture magnetic reconnection within the leading extremity of CME, resulting in the formation of mesoscale flux ropes, containing sufficiently strong magnetic fields (∼ 30 nT) to affect planetary magnetospheres. Finally, we use a tetrahedral configuration of four virtual probes, corresponding to the Space Weather Investigation Frontier (SWIFT) mission concept, to show that the mission can uniquely resolve the spatial characteristics and temporal evolution of reconnecting current sheets within the CME, as well as the resulting small- to mesoscale structures.
Predicting temporal clear water scour depth around bridge piers with XGBoost and SVM–PSO approaches
Authors: Baranwal Anubhav , Gaurav Prince , Reddy Lohit , Das Bhabani Shankar , Naik Balaji 
Published: November 2024

ABSTRACT
Scouring around a bridge pier involves removing sediment from the riverbed and banks due to water flow. This paper employs eXtreme Gradient Boosting (XGBoost) and support vector machine with particle swarm optimization (SVM-PSO) machine learning (ML) approaches to model the temporal local scour depth around bridge piers under clear water scouring (CWS) conditions. CWS datasets, incorporating bridge pier geometry, flow characteristics, and sediment properties, are collected from existing literature. Five non-dimensional influencing parameters, such as ratio of pier width to flow depth (b/y), ratio of approach mean velocity to critical velocity (V/Vc), ratio of mean sediment size to pier width (d50/b), Froude number (Fr), and standard deviation of sediment (σg), are chosen as input parameters. XGBoost and SVM-PSO ML models demonstrate superior predictive capabilities, achieving coefficient of determination (R2) values exceeding 0.90 and mean absolute percentage error (MAPE) and root mean square error (RMSE) values less than 17.07% and 0.0341, respectively. Comparison with the previous four empirical models based on statistical indices reveals that the proposed XGBoost model outperforms SVM-PSO and empirical models in predicting scour depth, so it is recommended for estimating clear water scour depth under varying temporal conditions within the specified dataset range.
Bioanalytical Method Development and Validation of Antihelmintic Drug in Human Plasma
Authors: Sapna Pandey A. , Jadhao Monika P. 
Published: November 2024

Triclabendazole is an anthelmintic or anti-worm medication. Asimple and sensitive bio-analytical HPLC method with UV detection was developed and validated triclabendazole in human plasma. The analytes were extracted from human plasma samples by liquid-liquid extraction technique. Triclabendazole showed maximum absorbance i.e.; λmax at 305 nm. The developed analytical method was validated as per ICH guidelines. The chromatographic separation was achieved with Hypersil BDS C18 (250 mm x 4.6 mm, Particle size: 5 µm), software Autochrom 3000 using a mobile phase composition of acetonitrile and buffer (60:40 V/V) at a flow rate of 1.2 mL/min with a run time of 7 min.
The method showed good linearity in correlation coefficient (r) of >0.9998. The LOD and LOQ were found to be 1.00 µg mL-1 and 3.02 mg mL-1, respectively. Accuracy and precision data were found to be less than 2%, indicating the suitability of method. The developed HPLC method in human plasma using protein precipitation extraction for sample preparation was found to be very simple, reliable, precise, accurate, sensitive and selective analytical method for the estimation of Tricalbendazole. The method is suitable for routine quantitative analysis in pharmaceutical dosage forms. The method developed can be used in therapeutic drug monitoring units, bioequivalence and bioavailability studies, pharmacokinetic and toxicology studies of Tricalbendazole.
Skin Aging and Herbal Anti-Aging Serums: A Comprehensive Review
Authors: Dileep Shintre Aniruddha , Dayanand Naikawadi Nishigandha , Redasani Dr. V.K. 
Published: November 2024

This review explores the intricate anatomy of the skin, giving a brief synopsis of its structure and role. It describes the various aspects of skin aging and the roles that both intrinsic and extrinsic factors play in this process of aging. Focusing on the topic of herbal medicines, the article investigates the scientifically proven anti-aging properties of a variety of herbs. It also provides information about the composition and varieties of serums, emphasizing important components such hyaluronic acid, vitamin C, vitamin B3, and herbal extracts that are effective in preventing facial ageing. The aim of this review is to provide readers with a comprehensive understanding of skin aging and the wide range of anti-aging techniques accessible, especially in the context of herbal based face serum
Review on Antimicrobial Polyherbal Cream
Authors: Sonwalkar Viraj S. , Naikwadi Nishiganda D. , Redasani V.K.Redasani , Redasani V.K. 
Published: November 2024

This review article explores the effectiveness of antimicrobial creams in addressing microbial infections and supporting skin health. It examines the mechanisms underlying microbial growth on the skin and the diverse range of antimicrobial agents utilized in cream formulations. Special emphasis is placed on the antimicrobial properties of various plants. Through comprehensive analysis, the article underscores the potential of antimicrobial creams as natural alternatives for managing skin infections and enhancing dermatological well-being.
Pharmacological evaluation of cellular and molecular mechanism of Anti-Inflammatory and Immunomodulatory effects of traditional herbal drug extract of Hedychium spicatum in Experimental Models of Bronchial Asthma
Authors: Gulati Kavita , Sharma Hemlata , Thokchom Suresh , Verma Pankaj , Ray Arunabha 
Published: November 2024

The study assessed the effects of standardized extracts of Hedychium spicatum on airway inflammation and immunomodulatory parameters in experimental model of bronchial asthma in rats. Wistar rats were immunized with ovalbumin (OVA) adsorbed on to aluminium hydroxide (i.p.) and challenged with aerosolized ovalbumin from day 15 to 22. Standardized extracts of Hedychium spicatum were administered orally for 22 days in different treatment groups. After 24h of last challenge, rats were anesthetized and blood and bronchoalveolar lavage fluid (BALF) were collected, centrifuged and analyzed for proinflammatory cytokines TNF-α, NF-κB, Th2 type cytokines IL-4 and cell count.The results showed that eosinophil cells levels were elevated in the immunized rats which were reduced in the treatment group Hedychium spicatum extract as compared to control. These results were comparable with the effects of the standard drug prednisolone. The results showed that extract of Hedychium spicatum has anti-inflammatory and immunomodulatory effects. Thus, the results suggest that the beneficial effects of Hedychium spicatum in bronchial asthma could be due to balancing influence on prooxidant-antioxidant status and reducing the airway inflammation.
Из опыта применения математического моделирования в процессе обучения студентов вузов математическим дисциплинам прикладного характера
Authors: С.А. Парыгина 
Published: November 2024

В статье рассмотрен пример применения реального математического моделирования в ходе обучения студентов разных направлений подготовки прикладным математическим дисциплинам, а именно: построение регрессионной математической модели, позволяющей регулировать влияние входных переменных на выходную переменную, с целью уменьшения такого распространенного дефекта как коррозия металла. В ходе моделирования выделено 10 значимых производственных факторов, выбрано уравнение множественной линейной регрессии этих факторов на выходную переменную Y, определяющую процент брака по причине коррозии. Значение коэффициента детерминации, равное 0,96, говорит о достаточно высокой точности моделирования. Детальное проникновение в суть построения математической модели позволяет студентам лучше понять алгоритм и нюансы реального математического моделирования.
The article considers using real mathematical modeling in the course of teaching students of different fields of study in applied mathematical disciplines, namely, building a regression mathematical model that allows regulating the influence of input variables on the output variable in order to reduce such a common defect as metal corrosion. During the process of modeling, 10 significant production factors were identified, an equation for multiple linear regression of these factors on the output variable Y was selected, which determines the percentage of defects due to corrosion. The value of the determination coefficient, equal to 0.96, indicates a fairly high accuracy of modeling. Detailed insight into the essence of constructing a mathematical model improves the students comprehension of the algorithm and real mathematical modeling nuances.
ANALISIS SOSIOLINGUISTIK DALAM FILM TENGGELAMNYA KAPAL VAN DER WIJCK
Authors: Saimuary Dana Indah , Simbolon Imelda Meilani , Hutabarat Rindu L.W. 
Published: November 2024

Abstrak Penelitian ini bertujuan untuk mendeskripsikan keterkaitan sosiolinguistik serta penerapannya terhadap film Tenggelamnya Kapal Van der Wijck. Data yang digunakan dalam penelitian ini adalah seluruh aspek kajian perspektif karya yang meliputi tema, diksi, gaya bahasa, imaji, dan amanat dalam film Tenggelamnya Kapal van der Wijk yang menggambarkan pengaruh adanya aspek sosiologi dan linguistik terhadap film Tenggelamnya Kapal Van der Wijck. Penelitian ini menggunakan metode dekriptif dengan pendekatan kualitatif. Teknik pengumpulan data pada penelitian ini adalah Teknik menonton, menyimak dan mencatat. Teknik dilakukan dengan menonton film, menyimak, kemudian dicatat untuk dianalisis berdasarkan kajian perspektifnya. Hasil penelitian yang diperoleh membuktikan sosiolinguistik sangat berpengaruh terhadap unsur pembangun film Tenggelamnya Kapal Van der Wijck. Kata Kunci: Sosiolinguistik, Film, Kajian Perspektif.
KEMISKINAN DALAM NOVEL DEKAT DAN NYARING KARYA SABDA ARMANDIO ALIF (TINJAUAN SOSIOLOGI SASTRA)
Authors: Fadilah Ridho Daffa 
Published: November 2024

AbstrakPenelitian ini membahas gambaran kemiskinan dalam novel Dekat dan Nyaring karya Sabda Armandio Alif dengan menggunakan tinjauan sosiologi sastra. Penelitian ini bertujuan untuk melihat bagaimana gambaran kemiskinan yang terdapat di dalam novel Dekat dan Nyaring Karya Sabda Armandio Alif. Penelitian ini menggunakan pendekatan sosiologi sastra dengan landasan teori yang dipakai adalah teori Alan Swingewood tentang karya sastra merupakan refleksi sosial atau cerminan zaman. Metode yang digunakan dalam penelitian ini adalah metode kualitatif yang menghasilkan data tertulis mengenai kemiskinan. Teknik yang digunakan adalah teknik pengumpulan data, analisis data, dan penyajian hasil analisis data. Dari penelitian yang telah dilakukan, dalam novel Dekat dan Nyaring karya Sabda Armandio Alif ditemukan ada tiga jenis kemiskinan, yaitu kemiskinan absolut, kemiskinan relatif, dan kemiskinan struktural.Kata kunci: novel, Sabda Armandio Alif, kemiskinan, Sosiologi Sastra. AbstractThis study discusses the description of poverty in the novel Dekat dan Nyaring by Sabda Armandio Alif using a review of the sociology of literature. This study aims to see how the description of poverty is contained in the novel Dekat dan Nyaring by Sabda Armandio Alif. This study uses a sociology of literature approach with the theoretical basis used is Alan Swingewood's theory that literary works are a social reflection or a reflection of the times. The method used in this study is a qualitative method which produces written data on poverty. The techniques used are data collection techniques, data analysis, and presentation of the results of data analysis. From the research that has been done, in the novel Dekat dan Nyaring by Sabda Armandio Alif it is found that there are three types of poverty, namely absolute poverty, relative poverty, and structural poverty.Keywords: novel, Sabda Armandio Alif, poverty, Sociology of Literature.
VARIASI LEKSIKAL BAHASA MINANGKABAU DI KECAMATAN RANAH PESISIR, KABUPATEN PESISIR SELATAN: KAJIAN DIALEKTOLOGI
Authors: Risani Maya , Nadra Nadra , Noviatri Noviatri 
Published: November 2024

Penelitian ini bertujuan untuk: 1) Mendeskripsikan variasi leksikal yang terdapat dalam bahasa Minangkabau di Kecamatan Ranah Pesisir; 2) Memetakan variasi leksikal bahasa Minangkabau; 3) Menghitung persentase variasi leksikal bahasa Minangkabau. Metode yang digunakan adalah metode cakap dilakukan dengan teknik dasar teknik pancing dan teknik lanjutan teknik cakap semuka. Dalam metode cakap digunakan teknik lanjutan, teknik catat dan teknik rekam. Pada tahap analisis data, digunakan metode padan referensial dan metode padan translasional yang dilakukan dengan teknik dasar teknik Pilah Unsur Penentu (PUP) dan teknik lanjutan teknik Hubung Banding Membedakan (HBB). Selanjutnya, pada tahap penyajian hasil analisis data, digunakan metode formal dan metode informal. Berdasarkan hasil penelitian yang dilakukan, (1) Variasi leksikal bahasa Minangkabau di Kecamatan Ranah Pesisir ditemukan sebanyak 190 dari 588 daftar pertanyaan yang diajukan. (2) Sebanyak 190 data variasi leksikal tersebut dipetakan dalam bentuk sistem lambang. (3) Hasil penghitungan dialektometri variasi leksikal bahasa Minangkabau yang ditemukan di Kecamatan Ranah Pesisir termasuk ke dalam kategori beda wicara dan tidak ada perbedaan, dengan hasil persentase sebanyak 17,00%–23,12%. Dari hasil persentase tersebut, daerah yang menunjukkan beda wicara karena secara geografis nagari tersebut letaknya terpencil dan rata-rata masyarakat nagari hanya lulusan SD dan SMP, sedangkan persentase daerah yang tidak menunjukkan perbedaan disebabkan oleh jarak masing-masing TP cukup berdekatan sehingga sering terjadi hubungan komunikasi antarmasyarakat. Kata kunci: bahasa Minangkabau, beda wicara, dialektologi, pemetaan, variasi leksikal
ANALISIS ASPEK LEKSIKAL REPETISI PADA FILM TILIK KARYA BAGUS SUMARTONO
Authors: Siallagan Lasenna , Khadijah Khadijah , Simanullang Rouli , Nadira Wulandari Ayu , Kifli Barli 
Published: November 2024

Penelitian ini bertujuan untuk mendeskripsikan aspek repetisi leksikal yang terdapat dalam film Tilik karya Bagus Sumartono. Metode penelitian yang digunakan adalah metode deskriptif kualitatif. Subjek penelitian ini merupakan tuturan dalam film Tilik karya Bagus Sumartono. Data dikumpulkan dengan menggunakan teknik simak- catat. Data yang terkumpul kemudian dianalisis dengan memilah bagian-bagian tuturan dalam film yang memuat aspek repetisi leksikal. Berdasarkan hasil analisis, terdapat 9 aspek repetisi leksikal pada film Tilik karya Bagus Sumartono. Aspek leksikal repetisi tersebut terdiri atas 5 repetisi anafora, 2 repetisi epistrof, 1 repetisi mesodiplosis, dan 1 repetisi anadiplosis. Kata Kunci: leksikal repetisi, film Tilik
ESTETIKA RESEPSI PENGURUS KOMUNITAS RUANG SASTRA (KORSAS) UNIVERSITAS NEGERI MEDAN TERHADAP CERPEN METAMORFOSA ROSA KARYA ALIURRIDHA
Authors: Lande Tri , Dewi Yuriska 
Published: November 2024

Komunitas Ruang Sastra Universitas Negeri Medan (Korsas Unimed) terhadap Cerpen Metamorfosa Rosa karya Aliurridha. Penelitian ini merupakan penelitian eksperimental. Penelitian ini menggunakan validitas semantis dan reliabilitas interrater dan intrarater. Instrumen yang digunakan dalam penelitian ini ialah peneliti sendiri dan dilengkapi dengan instrumen lain yaitu kuesioner atau angket resepsi pengurus komunitas berdasarkan aspek intelektual dan aspek emosional. Hasil penelitian menyimpulkan bahwa seluruh pernyatan pada kuesioner didominasi oleh pilihan setuju, secara keseluruhan cerpen Metamorfosa Rosa karya Aliurridha dinyatakan layak untuk menjadi bahan bacaan para responden dengan rentang skala skala 3—7 dan didominasi oleh pilihan pada skala 5 dan 6. Penilaian responden laki-laki terhadap aspek intelektual cenderung lebih tinggi, sedangkan penilaian responden perempuan cenderung lebih tinggi terhadap aspek emosional. Secara keseluruhan penilaian terhadap aspek intelektual pada cerpen tergolong baik dan layak dijadikan sebagai bahan bacaan sastra. Begitu pula dengan aspek emosional, secara keseluruhan penilaian terhadap aspek ini tergolong baik dan layak dijadikan sebagai bahan bacaan sastra karena membawa pembaca pada berbagai jenis keterlibatan personal dalam hal karakter dan tindakan. Kata kunci: Estetika Resepsi, Resepsi Sastra, komunitas, cerpen.