bluuebunny/crossref_metadata_2025_split huggingface dataset:
Host galaxies of high-redshift extremely red and obscured quasars
Authors: Zakamska Nadia L , Sun Ai-Lei , Strauss Michael A , Alexandroff Rachael M , Brandt W N , Chiaberge Marco , Greene Jenny E , Hamann Fred , Liu Guilin , Perrotta Serena , Ross Nicholas P , Wylezalek Dominika 
Published: July 2019

Abstract
We present Hubble Space Telescope 1.4–1.6 $\mu$m images of the hosts of 10 extremely red quasars (ERQs) and six type 2 quasar candidates at z = 2–3. ERQs, whose bolometric luminosities range between 1047 and 1048 erg s−1, show spectroscopic signs of powerful ionized winds, whereas type 2 quasar candidates are less luminous and show only mild outflows. After performing careful subtraction of the quasar light, we clearly detect almost all host galaxies. The median rest-frame B-band luminosity of the ERQ hosts in our sample is $10^{11.2}\, \mathrm{L}_{\odot }$, or ∼4L* at this redshift. Two of the 10 hosts of ERQs are in ongoing mergers. The hosts of the type 2 quasar candidates are 0.6 dex less luminous, with 2/6 in likely ongoing mergers. Intriguingly, despite some signs of interaction and presence of low-mass companions, our objects do not show nearly as much major merger activity as do high-redshift radio-loud galaxies and quasars. In the absence of an overt connection to major ongoing gas-rich merger activity, our observations are consistent with a model in which the near-Eddington accretion and strong feedback of ERQs are associated with relatively late stages of mergers resulting in early-type remnants. These results are in some tension with theoretical expectations of galaxy formation models, in which rapid black hole growth occurs within a short time of a major merger. Type 2 quasar candidates are less luminous, so they may instead be powered by internal galactic processes.
Clumpy galaxies in cosmological simulations: the effect of ISM model
Authors: Inoue Shigeki , Yoshida Naoki 
Published: July 2019

ABSTRACT
We study influence by models of interstellar medium (ISM) on properties of galaxies in cosmological simulations. We examine three models widely used in previous studies. The ISM models impose different equations of state on dense gas. Using zoom-in simulations, we demonstrate that switching the ISM models can control formation of giant clumps in massive discs at redshifts z ∼ 1–2, while their initial conditions and the other settings such as stellar feedback are unchanged. Thus, not only feedback but ISM models can also be responsible for clumpy morphologies of simulated galaxies. We find, however, that changing the ISM models hardly affects global properties of galaxies, such as the total stellar and gas masses, star formation rate, metallicity, and stellar angular momentum, irrespective of the significant difference of clumpiness; namely the ISM models only change clumpiness of discs. In addition, our approach provides a test to investigate impact by clump formation on the evolution of disc galaxies using the same initial conditions and feedback. We find that clump formation does not significantly alter the properties of galaxies and therefore could not be the causes of starburst or quenching.
Binary radial velocity measurements with space-based gravitational-wave detectors
Authors: Wong Kaze W K , Baibhav Vishal , Berti Emanuele 
Published: July 2019

ABSTRACT
Unlike traditional electromagnetic measurements, gravitational-wave observations are not affected by crowding and extinction. For this reason, compact object binaries orbiting around a massive black hole can be used as probes of the inner environment of the black hole in regions inaccessible to traditional astronomical measurements. The orbit of the binary’s barycentre around the massive black hole will cause a Doppler shift in the gravitational waveform, which is in principle measurable by future space-based gravitational-wave interferometers, such as the Laser Interferometer Space Antenna (LISA). We investigate the conditions under which these Doppler shifts are observable by LISA. Our results imply that Doppler shift observations can be used to study the central region of globular clusters in the Milky Way, as well the central environment of extragalactic massive black holes.
Rayleigh–Taylor unstable flames at higher Reynolds number
Authors: Hicks E P 
Published: July 2019

ABSTRACT
Rayleigh–Taylor (RT) unstable flames are a key component of Type Ia and Iax supernovae explosions, but their complex hydrodynamics is still not well understood. These flames are affected not only by the RT instability, but also by the turbulence it generates. Both processes can increase the flame speed by stretching and wrinkling the flame. This makes it hard to choose a subgrid model for the flame speed in full star Type Ia or Iax simulations. Commonly used subgrid models get around this difficulty by assuming that either the RT instability or turbulence is dominant and sets the flame speed. In previous work, we evaluated the physical assumptions and predictive abilities of these two types of models by analysing a large parameter study of 3D direct numerical simulations of RT unstable flames. Surprisingly, we found that the flame dynamics is dominated by the RT instability and that RT unstable flames are very different from turbulent flames. In particular, RT unstable flames are thinner rather than thicker when turbulence is strong. In addition, none of the turbulent flame speed models adequately predicted the flame speed. We also showed that the RT flame speed model failed when the RT instability was strong, suggesting that geometrical burning effects also influence the flame speed. However, these results depended on simulations with Re ≲ 720. In this paper, we extend the parameter study to higher Reynolds number and show that the basic conclusions of our previous study still hold when the RT-generated turbulence is stronger.
The complete local volume groups sample – III. Characteristics of group central radio galaxies in the Local Universe
Authors: Kolokythas Konstantinos , O’Sullivan Ewan , Intema Huib , Raychaudhury Somak , Babul Arif , Giacintucci Simona , Gitti Myriam 
Published: July 2019

ABSTRACT
Using new 610 and 235 MHz observations from the giant metrewave radio telescope (GMRT) in combination with archival GMRT and very large array (VLA) survey data, we present the radio properties of the dominant early-type galaxies in the low-richness subsample of the complete local-volume groups sample (CLoGS; 27 galaxy groups) and provide results for the radio properties of the full CLoGS sample for the first time. We find a high radio detection rate in the dominant galaxies of the low-richness subsample of 82 per cent (22/27); for the full CLoGS sample the detection rate is 87 per cent (46/53). The group-dominant galaxies exhibit a wide range of radio power, 1020–1025 W Hz−1 in the 235 and 610 MHz bands, with the majority (53 per cent) presenting point-like radio emission, 19 per cent hosting currently active radio jets, 6 per cent having remnant jets, 9 per cent being diffuse, and 13 per cent having no detected radio emission. The mean spectral index of the detected radio sources in the 235−610 MHz frequency range is found to be $\alpha _{235}^{610}\sim$0.68, and $\alpha _{235}^{1400}\sim$0.59 in the 235−1400 MHz one. In agreement with earlier studies, we find that the fraction of ultrasteep spectrum sources (α &gt; 1.3) is ∼4 per cent, mostly dependent on the detection limit at 235 MHz. The majority of point-like systems are found to reside in dynamically young groups, whereas jet systems show no preference between spiral-rich and spiral-poor group environments. The mechanical power of the jet sources in the low-richness sample groups is estimated to be ∼1042–1044 erg s−1 with their black hole masses ranging between 2 × 108 and 5 × 109 M⊙. We confirm previous findings that while radio jet sources tend to be associated with more massive black holes, black hole mass is not the decisive factor in determining jet activity or power.
Bayesian Estimation of Past Population Dynamics in BEAST 1.10 Using the Skygrid Coalescent Model
Authors: Hill Verity , Baele Guy 
Published: July 2019

AbstractInferring past population dynamics over time from heterochronous molecular sequence data is often achieved using the Bayesian Skygrid model, a nonparametric coalescent model that estimates the effective population size over time. Available in BEAST, a cross-platform program for Bayesian analysis of molecular sequences using Markov chain Monte Carlo, this coalescent model is often estimated in conjunction with a molecular clock model to produce time-stamped phylogenetic trees. We here provide a practical guide to using BEAST and its accompanying applications for the purpose of drawing inference under these models. We focus on best practices, potential pitfalls, and recommendations that can be generalized to other software packages for Bayesian inference. This protocol shows how to use TempEst, BEAUti, and BEAST 1.10 (http://beast.community/; last accessed July 29, 2019), LogCombiner as well as Tracer in a complete workflow.
Impacts of uORF codon identity and position on translation regulation
Authors: Lin Yizhu , May Gemma E , Kready Hunter , Nazzaro Lauren , Mao Mao , Spealman Pieter , Creeger Yehuda , McManus C Joel 
Published: July 2019

AbstractTranslation regulation plays an important role in eukaryotic gene expression. Upstream open reading frames (uORFs) are potent regulatory elements located in 5′ mRNA transcript leaders. Translation of uORFs usually inhibit the translation of downstream main open reading frames, but some enhance expression. While a minority of uORFs encode conserved functional peptides, the coding regions of most uORFs are not conserved. Thus, the importance of uORF coding sequences on their regulatory functions remains largely unknown. We investigated the impact of an uORF coding region on gene regulation by assaying the functions of thousands of variants in the yeast YAP1 uORF. Varying uORF codons resulted in a wide range of functions, including repressing and enhancing expression of the downstream ORF. The presence of rare codons resulted in the most inhibitory YAP1 uORF variants. Inhibitory functions of such uORFs were abrogated by overexpression of complementary tRNA. Finally, regression analysis of our results indicated that both codon identity and position impact uORF function. Our results support a model in which a uORF coding sequence impacts its regulatory functions by altering the speed of uORF translation.
C6orf203 is an RNA-binding protein involved in mitochondrial protein synthesis
Authors: Gopalakrishna Shreekara , Pearce Sarah F , Dinan Adam M , Rosenberger Florian A , Cipullo Miriam , Spåhr Henrik , Khawaja Anas , Maffezzini Camilla , Freyer Christoph , Wredenberg Anna , Atanassov Ilian , Firth Andrew E , Rorbach Joanna 
Published: July 2019

Abstract
In all biological systems, RNAs are associated with RNA-binding proteins (RBPs), forming complexes that control gene regulatory mechanisms, from RNA synthesis to decay. In mammalian mitochondria, post-transcriptional regulation of gene expression is conducted by mitochondrial RBPs (mt-RBPs) at various stages of mt-RNA metabolism, including polycistronic transcript production, its processing into individual transcripts, mt-RNA modifications, stability, translation and degradation. To date, only a handful of mt-RBPs have been characterized. Here, we describe a putative human mitochondrial protein, C6orf203, that contains an S4-like domain—an evolutionarily conserved RNA-binding domain previously identified in proteins involved in translation. Our data show C6orf203 to bind highly structured RNA in vitro and associate with the mitoribosomal large subunit in HEK293T cells. Knockout of C6orf203 leads to a decrease in mitochondrial translation and consequent OXPHOS deficiency, without affecting mitochondrial RNA levels. Although mitoribosome stability is not affected in C6orf203-depleted cells, mitoribosome profiling analysis revealed a global disruption of the association of mt-mRNAs with the mitoribosome, suggesting that C6orf203 may be required for the proper maturation and functioning of the mitoribosome. We therefore propose C6orf203 to be a novel RNA-binding protein involved in mitochondrial translation, expanding the repertoire of factors engaged in this process.
Should we continue to counsel families to use hydrolyzed formulas as a means of allergy prevention in high-risk infants?
Authors: Burke Megan , Chan Edmond S , Abrams Elissa M 
Published: July 2019

Abstract
The prevalence of food allergy in North America is high, and has increased over time. As a result, focus has shifted from treatment to allergy prevention. Previous studies have suggested that hydrolyzed formula may prevent atopic dermatitis in high-risk infants. As a result, multiple international guidelines including the Canadian Paediatric Society (CPS) position statement on allergy prevention recommend the use of hydrolyzed formula as a means of allergy prevention in mothers who are not breastfeeding or using donor breastmilk. However, a recent systematic review has not supported an association between use of hydrolyzed formula and allergy prevention. In addition, studies are emerging supporting the use of early and regular cow’s milk formula as a means of cow’s milk allergy prevention.
Unemployment and mortality in a large Italian cohort
Authors: d’Errico Angelo , Piccinelli Cristiano , Sebastiani Gabriella , Ricceri Fulvio , Sciannameo Veronica , Demaria Moreno , Di Filippo Paola , Costa Giuseppe 
Published: July 2019

AbstractBackgroundAim of this study was to examine the association between unemployment and mortality, taking into account potential confounders of this association. A secondary objective was to assess whether the association between unemployment and mortality was modified by lack of household economic resources.MethodsProspective cohort composed of a representative sample of Italian subjects 30–55 years who participated in the Italian National Health Survey 1999–2000, followed up for mortality up to 2012 (15 656 men and 11 463 women). Data were analyzed using Cox regression models, stratified by gender and adjusted for health status, behavioral risk factors, socioeconomic position and position in the household. The modifying effect of the lack of economic resources was assessed by testing its interaction with unemployment on mortality.ResultsAmong women, unemployment was not associated with mortality, whereas among men, higher mortality was found from all causes (HR = 1.82), which was not modified by lack of economic resources, and from neoplasms (HR = 1.59), cardiovascular diseases (HR = 2.58) and suicides (HR = 5.01).ConclusionsResults for men were robust to the adjustment for main potential confounders, suggesting a causal relationship between unemployment and mortality. The lack of effect modification by economic resources supports the relevance of the loss of non-material benefits of work on mortality.
The impact of fatigue in rheumatoid arthritis and the challenges of its assessment
Authors: Santos Eduardo J F , Duarte Catia , da Silva José A P , Ferreira Ricardo J O 
Published: July 2019

Abstract
Fatigue is one of the most important symptoms for patients with RA, and imposes a great burden on patients’ lives, being associated with significantly reduced health-related quality of life. Although being recognized by the rheumatology community as a major gap in the current management of the disease, fatigue has not been easy to measure and conceptualize. Part of the problem seems to reside in the multidimensional causality of this phenomenon, which may warrant dedicated measures and interventions. Although there are several instruments available to measure it, no consensus has yet been reached to recommend a ‘gold-standard’. This review aims at synthesizing the role of fatigue in the global impact of RA; describing validated instruments and their psychometric properties as measures of fatigue among patients with RA; and finally proposing a clinically meaningful, valid and feasible process to measure fatigue in clinical practice.
[18F]FDG positron emission tomography and ultrasound in the diagnosis of giant cell arteritis: congruent or complementary imaging methods?
Authors: Imfeld Stephan , Aschwanden Markus , Rottenburger Christof , Schegk Elke , Berger Christoph T , Staub Daniel , Daikeler Thomas 
Published: July 2019

Abstract

Objectives
[18F]Fluorodeoxyglucose (FDG)-PET/CT and US are both well established for diagnosing GCA. The present study investigates their accuracy and whether they provide overlapping or complementary information in a cohort of patients presenting with suspicion of GCA.

Methods
We selected consecutive patients from our cohort of suspected GCA cases that underwent both extended vascular US and PET/CT for diagnostic work-up between December 2006 and August 2012.

Results
A total of 102 patients were included. Diagnosis of GCA was confirmed in 68 patients and excluded in 34 patients (controls). Vasculitic changes in US were most often found in the temporal artery with 32 positive findings on each side, followed by the popliteal artery (10 right, 9 left) and the subclavian/axillary artery (7 right, 8 left). By contrast, PET/CT showed vasculitis most frequently in the vertebral (23 right, 33 left) and common carotid arteries (32 right, 24 left), followed by the subclavian arteries (16 right, 18 left), and the thoracic (17) and abdominal aorta (23). In 37/68 GCA patients PET/CT and US both revealed vasculitic findings, 11/68 had positive findings in US only and 14/68 in PET/CT only. Specificity of US was higher (one false-positive vs five false-positive in PET/CT). On a single segment level, only 20 of 136 positive segments were positive in both imaging modalities.

Conclusion
PET/CT measuring vessel wall metabolism and US vessel wall morphology showed a comparable diagnostic accuracy for GCA. However PET/CT and US were often discrepant within single vascular regions. Thus PET/CT and US should be considered as complementary methods, with a second imaging modality increasing the diagnostic yield by 16–20%.
Using pharmacogenetics in primary care
Authors: Murfin Melissa 
Published: July 2019

ABSTRACT
Pharmacogenetics offers a way to personalize medication prescribing for patients. Through the use of genetic tests that identify variations in enzymes important to drug metabolism, PAs can have patients' genetic information before prescribing a medication. This may reduce the risks of adverse reactions and lost treatment time when patients are given drugs to which they are unlikely to respond. Laboratory testing can identify common genetic variants that alter how the body metabolizes drugs. PAs with knowledge of these variants can choose medications that are more personalized and effective for each patient. Clinical pharmacogenetic guidelines are under development and will help providers identify which drugs are most likely to be affected by genetic variations so they can prescribe for patients based on their specific genetic phenotypes.
Outcomes of a Longitudinal Quality Improvement and Patient Safety Preclerkship Curriculum
Authors: Dumenco Luba , Monteiro Kristina , George Paul , Rougas Steven , Dollase Richard 
Published: July 2019

Purpose
To evaluate whether quality improvement (QI) and patient safety (PS) training in preclerkship medical education resulted in students’ development and retention of knowledge, application-based and perceived skills, and attitudes throughout clerkships.

Method
A longitudinal QI/PS curriculum with multimodal curricular components was implemented in the preclerkship curriculum between 2015 and 2017 at the Warren Alpert Medical School of Brown University, Rhode Island. Assessments were administered at baseline (T1), end of year 1 (T2), Clinical Skills Clerkship (T3), and end of clerkships (T4) in the intervention cohort (n = 97). In 2018, T4 data for this cohort were compared with a prior control cohort (n = 97) at T4.

Results
Results of knowledge-based multiple-choice questions (MCQs) (t[134] = −1.57, P < .001) and application-based skills (t[132] = −8.91, P < .001) demonstrated significant improvement from T1 to T2 (intervention cohort). Assessments of perceived skills showed significant growth from T1 to T2 (t[137] = −23.38, P < .001). Performance on application-based skills significantly improved from T2 to T3 (t[123] = −4.11, P < .001). Compared with the control cohort, the intervention cohort had significantly higher scores on MCQs (t[187.88] = 3.98, P < .001), application-based skills (t[72.69] = 6.40, P < .001), perceived skills (t[106.99] = 5.24, P < .001), and attitudes (t[152] = 5.86, P < .001).

Conclusions
Incorporation of preclerkship QI/PS training resulted in improvements in knowledge, application-based and perceived skills, and attitudes that were retained throughout clerkships.
Exploring the Socialization Experiences of Medical Students From Social Science and Humanities Backgrounds
Authors: Lam Justin T.H. , Hanson Mark D. , Martimianakis Maria Athina (Tina) 
Published: July 2019

Purpose
To explore the structural, cultural, and interpersonal issues that may contribute to the inadvertent marginalization of medical students with social science and humanities (SSH) backgrounds.

Method
Using the hidden curriculum as an analytic construct, the lead author interviewed 14 medical students with SSH backgrounds at the University of Toronto Faculty of Medicine from February to October 2015. The authors analyzed the interview transcripts for common themes around positive and negative cultural, structural, and interpersonal dimensions of the socialization process.

Results
Participants reported barriers to applying to medical school: needing to complete prerequisite courses and to do well on an exam geared toward those with a strong science background (the Medical College Admission Test) and lacking an application cohort. Some participants felt they were not ideal candidates for medical school. Participants appreciated how their SSH backgrounds and associated skill sets shaped both their perspectives on patient care and their developing professional identities. However, they perceived that others largely deemed their previous training as irrelevant, and they felt marginalized in medical school by peers, instructors, and the curriculum. These experiences led both to self-censorship, which enabled them to seem to conform to normative behaviors, and to the pursuit of reaffirming elective experiences.

Conclusions
The existing hidden curriculum inadvertently marginalizes SSH medical students; their experiences likely reflect the socialization experiences of other students from underrepresented backgrounds. Curricular and institutional reforms are imperative to shift the hidden curriculum toward one of epistemological inclusion that better supports students from nontraditional backgrounds.