bluuebunny/crossref_metadata_2025_split huggingface dataset:
Germination Biology of Sesbania (Sesbania cannabina): An Emerging Weed in the Australian Cotton Agro-environment
Authors: Iqbal Nadeem , Manalil Sudheesh , Chauhan Bhagirath S. , Adkins Steve W. 
Published: October 2018

AbstractSesbania [Sesbania cannabina(Retz.) Pers.] is a problematic emerging weed species in Australian cotton-farming systems. However, globally, no information is available regarding its seed germination biology, and better understanding will help in devising superior management strategies to prevent further infestations. Laboratory and glasshouse studies were conducted to evaluate the impact of various environmental factors such as light, temperature, salt, osmotic and pH stress, and burial depth on germination and emergence of two Australian biotypes ofS. cannabina. Freshly harvested seeds of both biotypes possessed physical dormancy. A boiling-water scarification treatment (100±2 C) of 5-min duration was the optimum treatment to overcome this dormancy. Once dormancy was broken, the Dalby biotype exhibited a greater germination (93%) compared with the St George biotype (87%). The nondormant seeds of both biotypes showed a neutral photoblastic response to light and dark conditions, with germination marginally improved (6%) under illumination. Maximum germination of both biotypes occurred under an alternating temperature regime of 30/20 and 35/25 C and under constant temperatures of 32 or 35 C, with no germination at 8 or 11 C. Seed germination of both biotypes decreased linearly from 87% to 14% with an increase in moisture stress from 0.0 to −0.8 MPa, with no germination possible at −1.0 MPa. There was a gradual decline in germination for both biotypes when imbibed in a range of salt solutions of 25 to 250 mM, with a 50% reduction in germination occurring at 150 mM. Both biotypes germinated well under a wide range of pH values (4.0 to 10.0), with maximum germination (94%) at pH 9.0. The greatest emergence rate of the Dalby (87%) and St George (78%) biotypes was recorded at a burial depth of 1.0 cm, with no emergence at 16.0 cm. Deep tillage seems to be the best management strategy to stopS. cannabina’s emergence and further infestation of cotton (Gossypium hirsutumL.) fields. The findings of this study will be helpful to cotton agronomists in devising effective, sustainable, and efficient integrated weed management strategies for the control ofS. cannabinain cotton cropping lands.
Signatures of Heavy Precipitation on the Thermodynamics of Clouds Seen From Satellite: Changes Observed in Temperature Lapse Rates and Missed by Weather Analyses
Authors: de la Torre Juárez Manuel , Padullés Ramon , Turk F. Joseph , Cardellach Estel 
Published: October 2018

AbstractAnalyses of the thermodynamics of precipitating clouds are mostly based on localized in situ campaigns or, more globally, weather analyses and reanalyses. This work presents a comparison of weather analyses to satellite observations and a radiometeorological method that shows how precipitating layers inside clouds coincide with weather analyses underestimates of the amount of water vapor. The thermodynamic information from inside precipitating clouds is extracted using observed radio occultation (RO) refractivity profiles without requiring weather analysis input, thus reducing analysis‐induced biases. The radiometeorological method is described by first identifying the differences between adiabatically dry, mixing‐ratio conserving, and saturated pseudoadiabatic refractivity profiles. These reference profiles are then compared to observed RO refractivity profiles within precipitating and nonprecipitating clouds to infer changes in their height‐dependent thermodynamic states and in stability to convection. Precipitation is found to start below layers close to pseudoadiabatic and precipitation layers coincide with changes into conditional stability against convection. A statistical comparison between observed profiles and the gradients predicted for a saturated pseudoadiabatic profile is made and finds that on the global average, precipitation separates clouds from the Clausius‐Clapeyron law and profiles are close to a saturated pseudoadiabat. The results (a) help constrain the physical processes associated to precipitation inside clouds and (b) validate the potential of graphical RO techniques to analyze observations without ancillary temperature data from weather analyses.
Projecting Changes in Societally Impactful Northeastern U.S. Snowstorms
Authors: Zarzycki C. M. 
Published: October 2018

AbstractThe northeastern United States is vulnerable to many impacts from snowfall‐producing winter cyclones that are amplified by the proximity of population centers to storm tracks. Historically, climatic snowfall assessments have centered around seasonal means even though local impacts typically occur at scales of hours to days. To detect snowstorms at the event level, an objective algorithm is defined based on the Regional Snowfall Index. The metric collocates storm snowfall with population to produce statistics of snowstorms with societal impacts. When applied to the Community Earth System Model Large Ensemble, broad declines in snowstorm frequency are projected by the later 21st century. These decreases are primarily due to a warmer atmosphere less conducive to snowfall as the predominant precipitation type. However, reductions are less significant for major events, since more hostile thermodynamic environments are partially offset by increased precipitation associated with cyclones that dynamically drive high‐impact snowstorms.
Plant Physiological Responses to Rising CO2 Modify Simulated Daily Runoff Intensity With Implications for Global‐Scale Flood Risk Assessment
Authors: Kooperman Gabriel J. , Fowler Megan D. , Hoffman Forrest M. , Koven Charles D. , Lindsay Keith , Pritchard Michael S. , Swann Abigail L. S. , Randerson James T. 
Published: October 2018

AbstractClimate change is expected to increase the frequency of flooding events and, thus, the risks of flood‐related mortality and infrastructure damage. Global‐scale assessments of future flooding from Earth system models based only on precipitation changes neglect important processes that occur within the land surface, particularly plant physiological responses to rising CO2. Higher CO2 can reduce stomatal conductance and transpiration, which may lead to increased soil moisture and runoff in some regions, promoting flooding even without changes in precipitation. Here we assess the relative impacts of plant physiological and radiative greenhouse effects on changes in daily runoff intensity over tropical continents using the Community Earth System Model. We find that extreme percentile rates increase significantly more than mean runoff in response to higher CO2. Plant physiological effects have a small impact on precipitation intensity but are a dominant driver of runoff intensification, contributing to one half of the 99th and one third of the 99.9th percentile runoff intensity changes.
Regional Changes in the Mean Position and Variability of the Tropical Edge
Authors: Totz Sonja , Petri Stefan , Lehmann Jascha , Coumou Dim 
Published: October 2018

AbstractRecent studies indicate that the tropical belt has been expanding during recent decades, which can significantly influence precipitation in subtropical climates. Often the location of the tropical border is identified using the Hadley cell edge (HCE) or the subtropical jet stream (STJ), but most studies concentrated on the zonal‐mean state, thereby missing regional impacts. Here we detect longitudinal‐resolved trends in STJ cores and HCEs over 1979–2016 in both hemispheres at a higher spatial and temporal resolution than previous studies. Besides pronounced regional trend differences in both sign and magnitude, we show that winter HCE and STJ variability increased in the Mediterranean region and decreased over the American and Asian continents. Rainfall variability in these regions changed likewise, and most of those changes can be explained by changes in HCE/STJ variability. This highlights the importance of understanding future tropical belt changes both regionally and in terms of variability.
The Relative Importance of Factors Influencing Tropical Cyclone Rapid Intensity Changes
Authors: Prasanth Sai , Haddad Ziad S. , Hristova‐Veleva Svetla M. , Marks Jr. F. D. 
Published: October 2018

AbstractPredicting rapid intensity changes in tropical cyclones (TCs) is a major challenge due to the influence of multiple competing processes within the vortex and in the TC environment. We present an empirical framework that quantifies the relative importance of the various factors that influence critical transitions in TC intensities. Our analysis of model simulations of recent TCs over the Bay of Bengal identifies the following variables within the vortex as the biggest influence on TC rapid intensity changes: the amplitudes of wave number 1 of the precipitation in the rainband region and the 700‐to 850‐mb horizontal moisture flux convergence and the amplitude of wave number 0 of precipitation within the radius of maximum winds. Likewise, the most important environmental variables identified are the angle between the driest air and the shear vector and the magnitude of vertical wind shear. These findings provide guidance on guidance for future observational efforts and data assimilation into TC forecasting models.
Geophysical Constraints on the Relationship Between Seamount Subduction, Slow Slip, and Tremor at the North Hikurangi Subduction Zone, New Zealand
Authors: Barker Daniel H. N. , Henrys Stuart , Caratori Tontini Fabio , Barnes Philip M. , Bassett Dan , Todd Erin , Wallace Laura 
Published: October 2018

AbstractWe use a prestack depth migration reflection image and magnetic anomaly data across the northern Hikurangi subduction zone, New Zealand, to constrain plate boundary structure and geometry of a subducting seamount in a region of shallow slow slip and recent International Ocean Discovery Program drilling. Our 3‐D model reveals the subducting seamount as a SW‐NE striking, lozenge‐shaped ridge approximately 40 km long and 15 km wide, with relief up to 2.5 km. This seamount broadly correlates with a 20‐km‐wide gap separating two patches of large (>10 cm) slow slip and the locus of tectonic tremor associated with the September–October 2014 Gisborne slow slip event. Largest slow slip magnitudes occurred where the décollement is underlain by a 3.0‐km‐thick zone of highly reflective subducting sediments. Wave speeds within this zone are 7% lower than adjacent and overlying strata, supporting the view that high fluid pressures within subducting sediments may facilitate shallow slow slip along the north Hikurangi margin.
Earthquake Rupture in Fault Zones With Along‐Strike Material Heterogeneity
Authors: Huang Yihe 
Published: October 2018

AbstractGeological and geophysical observations reveal along‐strike fault zone heterogeneity on major strike‐slip faults, which can play a significant role in earthquake rupture propagation and termination. I present 2‐D dynamic rupture simulations to demonstrate rupture characteristics in such heterogeneous fault zone structure. The modeled rupture is nucleated in a damaged fault zone and propagates on a preexisting fault toward the zone of intact rocks. There is an intermediate range of nucleation lengths that only allow rupture to spontaneously propagate in the damaged fault zone but not in a homogeneous medium given the same stresses and frictional parameters. Rupture with an intermediate nucleation length tends to stop when it reaches the zone of intact rocks for uniform fault stress conditions, especially when the rupture propagation distance in the damaged fault zone is relatively short and when the damaged fault zone is relatively narrow or smooth in the fault‐normal direction. Pronounced small‐scale heterogeneity within the damaged fault zone also contributes to such early rupture termination. In asymmetric fault zones bisected by a bimaterial fault, rupture moving in the direction of slip of faster rocks tends to terminate under the same conditions as in symmetric fault zones, whereas rupture moving in the direction of slip of slower rocks can penetrate into the zone of intact rocks. A sufficiently large asperity located at the edge of the zone of intact rocks also allows break‐through rupture. The results suggest that the along‐strike fault zone heterogeneity can play a critical role in seismicity distribution.
X‐Band Radar Mapping of Morphological Changes at a Dynamic Coastal Inlet
Authors: Rogowski Peter , de Paolo Tony , Terrill Eric , McNinch Jesse 
Published: October 2018

AbstractRemote sensing of the complex interactions between bathymetry, tidal flow, and waves in coastal inlets provides high‐resolution data sets that can be exploited to characterize the morphological variability of shallow ebb tidal deltas (ETD). Here we used observations from a mobile X‐band radar platform to determine optimal conditions during which radar‐derived shoal signatures best represent positions of underlying shoals. Significant increases in the spatial errors of radar shoal signatures were observed when offshore wave energy intensified. Consequently, the lowest spatial errors occurred when the radar shoal signatures were primarily a function of the tidal flow (i.e., low sea state). We used these findings to quantify shoal migration patterns at the New River Inlet, North Carolina. We found that the southwestern portion of the ETD had the largest morphological variability with typical shoreward migration rates of 2–3 m/day driven by incident wave energy. The migration rates and patterns estimated from X‐band observations were consistent with numerical modeling results and a previous video‐based New River remote sensing study. Our results confirm that X‐band radar can be used to quickly map shallow ETDs (e.g., 5 min of observations), allowing for rapid morphological assessments from shore or boat‐based platforms. The methods would prove particularly useful for initial assessment as well as continual monitoring of dynamic tidal inlets where large morphological responses can be rapidly assessed and used for geomorphological studies, and as decision aids for maritime or engineering operations.
The Seismic Potential in the Seismic Gap Between the Wenchuan and Lushan Earthquakes Revealed by the Joint Inversion of Receiver Functions and Ambient Noise Data
Authors: Liu Zhiqiang , Liang Chuntao , Hua Qian , Li Ying , Yang Yihai , He Fujun , Fang Lihua 
Published: October 2018

AbstractBased on a dense seismic array deployed to monitor the seismic gap between the Wenchuan and Lushan earthquakes, a joint inversion of dispersion curves and receiver functions yielded a fine velocity structure in this region with the highest resolution of approximately 20 km. The results show that the upper crust of the Songpan‐Ganzi terrane overthrusted onto the basement of the Sichuan Basin, indicating that the crustal shortening model may be the major mechanism that accounts for the growth of the Longmenshan. The results also show a low‐velocity zone (Vs < 3.5 km/s) and thickened crust (>67 km) beneath the seismic gap, which could be associated with partial melting. The heat transferred from the partial melting at the base of the seismic gap may increase the temperature of the faults to as high as 300–400 °C and cause the segment of the Longmenshan Fault in the seismic gap to become “aseismic.” In contrast, the Shuangshi‐Dachuan Fault, Dayi Fault, and other blind faults to the east‐southeast of the seismic gap are located above a high‐velocity body. The seismogenic environment of these faults is similar to the segments ruptured during the Wenchuan and Lushan earthquakes, both of which occurred above the westward extension of the strong Sichuan Basin. Higher seismic activity was also observed along these faults than that above the low‐velocity zone. Therefore, we deduce that a major earthquake on these faults is possible and that the magnitude could be larger than that of the Dayi earthquake (M 6.2).
Constraints on the Cenozoic Deformation of the Northern Eastern Cordillera, Colombia
Authors: Siravo G. , Fellin M. G. , Faccenna C. , Bayona G. , Lucci F. , Molin P. , Maden C. 
Published: October 2018

AbstractThe Eastern Cordillera of Colombia rose to maximum elevations of >5 km during the Cenozoic by inversion of a Mesozoic rift basin. Previous studies proposed that the exhumation of the Eastern Cordillera increased from ~6 Ma to the present due to the interplay between tectonic shortening and climate. In this study, we integrate new field observations, structural data, low‐temperature thermochronology, thermobarometry, and vitrinite reflectance along a section through the Tablazo, Cocuy, and Llanos regions to estimate the amount of shortening and the exhumation history. Our results indicate that shortening started as early as the latest Maastrichtian‐Paleocene in the Tablazo and Cocuy regions. Exhumation migrated eastward, starting in the Paleocene in the west and continuing in the Miocene in the east. The amount and rate of exhumation peaked in the Cocuy region with values of <5 km and < 0.4 km/Ma, respectively. At the highest elevations in the Cocuy Sierra, we also found evidence of a low‐pressure/high‐temperature metamorphic overprint, possibly related to shallow and local magmatic intrusions that occurred in the Late Miocene. Our cross‐section interpretation suggests a low amount of shortening (13%) that is mainly accommodated by high‐angle inverted faults and by the frontal thrust system. The presence of shallow magmatic bodies, moderate exhumation, and low shortening raises questions about the processes (isostatic versus dynamic) that drove the topographic growth of the high Cocuy Sierra.
Plau and Tgfbr3 are YAP-regulated genes that promote keratinocyte proliferation
Authors: Corley Susan M. , Mendoza-Reinoso Veronica , Giles Nichole , Singer Emma Suwanun , Common John E. , Wilkins Marc R. , Beverdam Annemiek 
Published: October 2018

AbstractYes-associated protein (YAP) is a mechanosensor protein and a downstream effector of the Hippo kinase pathway, which controls organ growth, cell proliferation, survival, maintenance and regeneration. Unphosphorylated YAP translocates to the nucleus where it acts as a cofactor of primarily the TEAD transcription factors to activate target gene transcription and cell proliferation. Perturbed YAP activation results in tumorigenesis. The pathways downstream of activated YAP that drive cell proliferation remain relatively unexplored. In this study, we employed YAP2-5SA-∆C transgenic mice, which overexpress a mildly activated YAP mutant protein in basal keratinocytes leading to increased proliferation of the epidermal stem/progenitor cell populations. We performed massively-parallel sequencing of skin biopsy mRNA (RNA-Seq) and found dysregulation of 1491 genes in YAP2-5SA-∆C skin, including many with roles in cell activation and proliferation. Furthermore, we found that 150 of these dysregulated genes harbored YAP/TEAD binding motifs in the 3′ UTR, suggesting that these may be direct YAP/TEAD target genes in the control of epidermal regeneration. Further validation and functional characterization assays identified Plau and Tgfbr3 as prime candidate genes that may be activated by epidermal YAP activity in the mouse skin in vivo to promote keratinocyte proliferation. This study provides novel insights into the mechanisms regulated by YAP that control tissue homeostasis, and in particular in conditions where YAP is aberrantly activated such as in neoplastic and regenerative skin disease.
APE1 stimulates EGFR-TKI resistance by activating Akt signaling through a redox-dependent mechanism in lung adenocarcinoma
Authors: Lu Guo-Shou , Li Mengxia , Xu Cheng-Xiong , Wang Dong 
Published: October 2018

AbstractEpidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) have become the standard first-line treatment for advanced lung adenocarcinoma (LUAD) cancer patients with activating EGFR mutations. However, most patients show acquired resistance to EGFR-TKIs, thereby resulting in a modest overall survival benefit. Here, we found that expression level of APE1 was closely associated with TKI resistance in LUAD. Our clinical data show that level of APE1 was inversely correlated with progression-free survival rate and median time to progression in EGFR-mutated LUAD patients. Additionally, we observed increased expression of APE1 in TKI-resistant LUAD cell lines compared to their parental cell lines. Overexpression of APE1-protected TKI-sensitive LUAD cells from TKI-induced cell growth inhibition and cell death. In contrast, inhibition of APE1-enhanced TKI-induced apoptosis, cell growth inhibition and tumor growth inhibition in TKI-resistant LUAD. In addition, we identified that APE1 positively regulates Akt activation and APE1 overexpression-induced TKI resistance was attenuated by inhibition of Akt activity. Finally, we demonstrated that inhibition of the redox function of APE1 enhances the sensitivity of TKI-resistant LUAD cells to TKI treatment and inhibits Akt phosphorylation in TKI-resistant LUAD cells, but not by inhibition of the APE1 DNA repair function. Taken together, our data show that increased expression of APE1 significantly contributes to TKI resistance development in LUAD, and targeting APE1 may reverse acquired resistance of LUAD cells to TKI treatment. Additionally, our data show that APE1 regulates TKI resistance in LUAD cells by activating Akt signaling through a redox-dependent mechanism.
Src-family kinase-Cbl axis negatively regulates NLRP3 inflammasome activation
Authors: Chung I-Che , Yuan Sheng-Ning , OuYang Chun-Nan , Lin Hsin-Chung , Huang Kuo-Yang , Chen Yu-Jen , Chung An-Ko , Chu Ching-Liang , Ojcius David M. , Chang Yu-Sun , Chen Lih-Chyang 
Published: October 2018

AbstractActivation of the NLRP3 inflammasome is crucial for immune defense, but improper and excessive activation causes inflammatory diseases. We previously reported that Pyk2 is essential for NLRP3 inflammasome activation. Here we show that the Src-family kinases (SFKs)-Cbl axis plays a pivotal role in suppressing NLRP3 inflammasome activation in response to stimulation by nigericin or ATP, as assessed using gene knockout and gene knockdown cells, dominant active/negative mutants, and pharmacological inhibition. We reveal that the phosphorylation of Cbl is regulated by SFKs, and that phosphorylation of Cbl at Tyr371 suppresses NLRP3 inflammasome activation. Mechanistically, Cbl decreases the level of phosphorylated Pyk2 (p-Pyk2) through ubiquitination-mediated proteasomal degradation and reduces mitochondrial ROS (mtROS) production by contributing to the maintenance of mitochondrial size. The lower levels of p-Pyk2 and mtROS dampen NLRP3 inflammasome activation. In vivo, inhibition of Cbl with an analgesic drug, hydrocotarnine, increases inflammasome-mediated IL-18 secretion in the colon, and protects mice from dextran sulphate sodium-induced colitis. Together, our novel findings provide new insights into the role of the SFK-Cbl axis in suppressing NLRP3 inflammasome activation and identify a novel clinical utility of hydrocortanine for disease treatment.