bluuebunny/crossref_metadata_2025_split huggingface dataset:
Some Considerations in the Design of Low Cost Remotely-Piloted Aircraft for Civil Remote Sensing Applications
Authors: Tomlins G. F. 
Published: July 2019

Early in 1982, B.C. Research began to evaluate the feasibility, advantages and limitations of using Remotely-Piloted Aircraft (RPA) to acquire aerial photography in environmental applications. Advantages associated with these aircraft include low costs, ease of operation, low noise levels, portability, safety and very low speed-low altitude capability. In the first phase of this program, a three-meter span fixed-wing aircraft was constructed from a commercial model kit and modified to carry a remotely-operated 35 mm camera system. In summer 1982, this system was used to acquire aerial photography in a variety of applications including forestry, pollution detection, wildlife habitat assessment, site mapping, publicity, wildlife inventories and shoreline mapping. Various operational limitations were encountered including difficulty of navigation and aircraft control, the fragility of the “model” airframe and its limited payload capability. These limitations are being addressed in Phase II of the program, during which a purpose-built airframe is under development, equipped with automatic flight controllers and emergency systems, and employing digitally-encoded radio signals for secure aircraft command. A black-and-white video camera installed in the airframe provides real-time imagery as an aid to navigation and photoframing.
LARGE-SCALE AERIAL PHOTOGRAPHIC SYSTEMS FOR FOREST SAMPLING IN CANADA
Authors: Spencer Ray D. 
Published: July 2019

Large-scale aerial photography is a tool that can provide relevant, timely and cost-effective information on forest quantities and conditions to improve planning and management. Accordingly, Canadians have pioneered two different photographic approaches: the first uses synchronized twin vertical cameras with a fixed airbase; the second approach uses a single camera with tilt recorder and a radar or laser altimeter. The paper discusses the development of these approaches for forest sampling in Canada.
COMPUTERIZED SOLUTION FOR LAND SUBDIVISION
Authors: Shmutter B. , Doytsher Y. 
Published: July 2019

Various problems arise in the process of replanning a land settlement and preparing a new cadastral map. These concern the processing of data digitized from maps, the intersecting of layers of information, and the preparation of data for graphical display. A software system for solving these problems has been developed and an account of its main features and examples illustrating the solutions are presented. The system can be executed on small computers (personal computers for example), is efficient and elevates cadastral mapping to a high level of automation.
Long Noncoding RNA FAM225A Promotes Nasopharyngeal Carcinoma Tumorigenesis and Metastasis by Acting as ceRNA to Sponge miR-590-3p/miR-1275 and Upregulate ITGB3
Authors: Zheng Zi-Qi , Li Zhi-Xuan , Zhou Guan-Qun , Lin Li , Zhang Lu-Lu , Lv Jia-Wei , Huang Xiao-Dan , Liu Rui-Qi , Chen FoPing , He Xiao-Jun , Kou Jia , Zhang Jian , Wen Xin , Li Ying-Qin , Ma Jun , Liu Na , Sun Ying 
Published: July 2019

Abstract

Long noncoding RNAs (lncRNA) play important roles in the tumorigenesis and progression of cancers. However, the clinical significance of lncRNAs and their regulatory mechanisms in nasopharyngeal carcinogenesis (NPC) are largely unknown. Here, based on a microarray analysis, we identified 384 dysregulated lncRNAs, of which, FAM225A was one of the most upregulated lncRNAs in NPC. FAM225A significantly associated with poor survival in NPC. N(6)-Methyladenosine (m6A) was highly enriched within FAM225A and enhanced its RNA stability. FAM225A functioned as an oncogenic lncRNA that promoted NPC cell proliferation, migration, invasion, tumor growth, and metastasis. Mechanistically, FAM225A functioned as a competing endogenous RNA (ceRNA) for sponging miR-590-3p and miR-1275, leading to the upregulation of their target integrin β3 (ITGB3), and the activation of FAK/PI3K/Akt signaling to promote NPC cell proliferation and invasion. In summary, our study reveals a potential ceRNA regulatory pathway in which FAM225A modulates ITGB3 expression by binding to miR-590-3p and miR-1275, ultimately promoting tumorigenesis and metastasis in NPC.

Significance:
These findings demonstrate the clinical significance of the lncRNA FAM225A in nasopharyngeal carcinoma (NPC) and the regulatory mechanism involved in NPC development and progression, providing a novel prognostic indicator and promising therapeutic target.
Targeting Cancer Cell Metastasis by Converting Cancer Cells into Fat
Authors: Ishay-Ronen Dana , Christofori Gerhard 
Published: July 2019

Abstract
Cancer is a systemic heterogeneous disease that can undergo several rounds of latency and activation. Malignant tumors evolve through dynamic responses to microenvironmental signals and development of resistance following therapeutic interventions. Cancer cell adaptation is required for cell survival during metastatic dissemination and outgrowth. Epithelial–mesenchymal transition (EMT) plays a major role in facilitating cell plasticity in cancer and allows cancer cells to escape chemotherapies and targeted therapies through dedifferentiation and signaling adaptation processes. In our recent study, we showed that breast cancer cells that have undergone EMT can be terminally differentiated into adipocytes using the PPARγ agonist rosiglitazone combined with the MEK inhibitor trametinib. The conversion of invasive cancer cells into adipocytes repressed primary tumor invasion and metastasis formation in mouse models of breast cancer. The transdifferentiated cancer cell–derived adipocytes were growth-arrested and lost their cellular plasticity. These results indicate the high potential of utilizing the increased cell plasticity inherent to invasive cancer cells for transdifferentiation therapy.
Anticancer Immunotherapy by MFAP5 Blockade Inhibits Fibrosis and Enhances Chemosensitivity in Ovarian and Pancreatic Cancer
Authors: Yeung Tsz-Lun , Leung Cecilia S. , Yip Kay-Pong , Sheng Jianting , Vien Long , Bover Laura C. , Birrer Michael J. , Wong Stephen T.C. , Mok Samuel C. 
Published: July 2019

Abstract

Purpose:
Recent studies demonstrate the role of the tumor microenvironment in tumor progression. However, strategies used to overcome the malignant phenotypes of cancer cells modulated by the microenvironment have not been thoroughly explored. In this study, we evaluated the therapeutic efficacy of a newly developed mAb targeting microfibril-associated protein 5 (MFAP5), which is secreted predominately by cancer-associated fibroblast (CAF), in ovarian and pancreatic cancer models.
Experimental Design: MAbs were developed using human MFAP5 recombinant protein as an antigen in mice, and antibodies from hybridoma clones were evaluated for their specificity to human and murine MFAP5. An Octet RED384 system was used to determine the kinetics of binding affinity and the specificity of the antibody clones, which were followed by epitope mapping and functional characterization by in vitro assays. The therapeutic efficacy of a lead anti-MFAP5 antibody clone 130A in tumor suppression was evaluated by ovarian tumor– and pancreatic tumor–bearing mouse models.

Results:
Three hybridoma clones, which produced antibodies with high affinity and specificity to MFAP5, were selected for functional studies. Antibody clone 130A, which recognizes a common epitope shared between human and murine MFAP5 protein, was further selected for in vivo studies. Results showed that clone 130A downregulated MFAP5-induced collagen production in CAFs, suppressed intratumoral microvessel leakiness, and enhanced paclitaxel bioavailability in both ovarian and pancreatic cancer mouse models.

Conclusions:
These data suggest that MFAP5 blockade using an immunologic approach inhibits fibrosis, induces tumor vessel normalization, and enhances chemosensitivity in ovarian and pancreatic cancer, and can be used as a novel therapeutic agent.
Lung Recruitment Maneuvers for ARDS Patients: A Systematic Review and Meta-Analysis
Authors: Cui Yu , Cao Rong , Wang Yu , Li Gen 
Published: July 2019

<b><i>Background:</i></b> Lung recruitment maneuvers (LRMs) may reduce mortality and improve oxygenation in patients with acute respiratory distress syndrome (ARDS). However, the existing literature provides controversial conclusions. <b><i>Objectives:</i></b> To determine whether LRMs have benefits on ARDS patients. <b><i>Searching Methods:</i></b> We searched relevant studies in PubMed, EMBASE, Medline, and the Cochrane Library up to May 2018. We considered for inclusion all prospective and randomized controlled trials which compared LRMs and non-LRM in adult patients with ARDS. We collected data about in-hospital mortality, 28-day mortality, the length of ICU and hospital stay, PaO<sub>2</sub>/FiO<sub>2</sub>, and FiO<sub>2</sub>. <b><i>Main Results:</i></b> Ten trials including 3,025 patients were analyzed. No significant difference was found in the hospital and 28-day mortality, as well as the length of ICU stay and oxygen requirement, even undergoing subgroup analysis. However, the results of this meta-analysis showed a significant benefit of LRMs for shortening the length of hospital stay (mean difference, MD = –1.75; 95% CI, –3.40 to –0.09; <i>p</i> = 0.04; <i>p</i> for heterogeneity = 0.3, <i>I</i><sup>2</sup> = 18%) and improving PaO<sub>2</sub>/FiO<sub>2</sub> ratio on the third day (MD = 52.72; 95% CI, 18.77–86.67; <i>p</i> = 0.002), but with extremely high heterogeneity (<i>p</i> for heterogeneity &#x3c;0.0001, <i>I</i><sup>2</sup> = 99%). <b><i>Conclusion:</i></b> LRMs do not produce significant reduction of mortality in patients with ARDS but may shorten the length of hospital stay and improve oxygenation on the third day. However, the results must be interpreted cautiously as most studies were on multiple intervention exposures.
Resenha de 'Vergonha no self e na sociedade: a sociologia e a antropologia das emoções de Thomas Scheff', de Mauro Guilherme Koury (org.) e Raoni Borges Barbosa (trad.)
Authors: Bernardo Aristides Ariel 
Published: July 2019

Referência completa:
Koury, Mauro Guilherme Pinheiro; Barbosa, Raoni Borges (Org. e trad.). Vergonha no self e na sociedade: a sociologia e a antropologia das emoções de Thomas Scheff. Recife: Ed. Bagaço, João Pessoa: Edições do GREM, 2016. [Coleção Cadernos do GREM, n. 10].
Longer Length of Delayed-Contrast Filling of Clot on 4-Dimensional Computed Tomographic Angiography Predicts Cardiogenic Embolism
Authors: Zhou Ying , Xu Chao , Zhang Ruiting , Shi Feina , Liu Chang , Yan Shenqiang , Ding Xinfa , Zhang Minming , Lou Min 
Published: July 2019

Background and Purpose—
We hypothesized the length of delayed-contrast filling sign (DCFS) of intraarterial clot, indicating contrast medium penetration into the thrombus, was associated with stroke etiology.

Methods—
We retrospectively included patients with large vessel occlusion in anterior circulation who underwent computed tomographic perfusion within 24 hours poststroke onset. We defined DCFS as contrast medium diffusion through the thrombi after the arterial peak phase on 4-dimensional computed tomographic angiography derived from computed tomographic perfusion. We measured the length of DCFS and investigated its value for predicting the stroke etiology.

Results—

Three hundred twenty-one patients were analyzed, and their stroke etiologies included cardiogenic embolism (CE, n=167), large artery atherosclerosis (n=64), other etiology group (n=4), and undetermined etiology (n=86). CE patients had longer length of DCFS than non-CE patients (2.3 versus 0.5 mm;
P
<0.001). The optimal cutoff value of DCFS length for predicting CE was 1.5 mm. The sensitivity, specificity, positive predictive value, and negative predictive value of a length of DCFS >1.5 mm for predicting CE were 83.2%, 70.8%, 75.5%, and 79.6%.

Conclusions—
Longer length of DCFS was associated with CE in patients with large vessel occlusion in anterior circulation, which may provide stroke etiology information.
The evolution of research on organizational termination
Authors: Lim Jae Young 
Published: July 2019

Over recent decades, termination research has experienced a transformation from an obscure field to one undergoing rapid growth. Since the inception of the research in the 1970s, ever-increasing worldwide calls for government austerity have demanded a systemic understanding of organizational termination. This article examines the evolution of organizational termination research from case-based to statistical studies. It then makes several suggestions regarding ways to move organizational termination research forward. Points for practitioners This article offers practical lessons to practitioners who are interested in understanding organizational termination. Offering the evolution of the research on organizational termination from its inception to the present, the article presents a succinct overview of organizational termination. As such, it will be beneficial to those who have to operate in today’s world of increasing fiscal austerity pressures.
Significant Publications on Infectious Diseases Pharmacotherapy in 2018
Authors: Borjan Jovan , Gonzales-Luna Anne J. , Carlson Travis J. , Finch Natalie A. , Mitchell Ardath P. , McDaneld Patrick M. , Phe Kady , Foolad Farnaz 
Published: July 2019

Purpose: To summarize the top 10 most influential peer-reviewed infectious diseases (ID) pharmacotherapy articles published in the year 2018. Summary: Members of the Houston Infectious Diseases Network (HIDN) nominated articles that were thought to have most notably contributed to ID pharmacotherapy in 2018, including those related to human immunodeficiency virus (HIV). A total of 26 articles were nominated: 22 articles pertaining to general ID pharmacotherapy and 4 articles involving HIV/AIDS. To select the most significant articles of 2018, a survey was created and distributed to members of the Society of Infectious Diseases Pharmacists (SIDP) asking members to vote on their top 10 general ID publications and 1 HIV publication. Of the 462 members surveyed, 213 (46%) and 108 (23%) voted for general ID pharmacotherapy- and HIV-related articles, respectively. The top article(s) for both categories are summarized. Conclusion: With the increased emphasis on antimicrobial stewardship initiatives and the growing problem of multidrug-resistant (MDR) organisms, the amount of ID literature centered on stewardship, appropriate treatment durations, and newly approved antimicrobial agents continues to expand, making it challenging for clinicians to stay informed on the most relevant publications. This review summarizes significant ID-related publications in 2018 with the goal of aiding clinicians in staying up to date on the most noteworthy publications in ID pharmacotherapy.
Medication-Related Osteonecrosis of the Jaw: MASCC/ISOO/ASCO Clinical Practice Guideline
Authors: Yarom Noam , Shapiro Charles L. , Peterson Douglas E. , Van Poznak Catherine H. , Bohlke Kari , Ruggiero Salvatore L. , Migliorati Cesar A. , Khan Aliya , Morrison Archie , Anderson Holly , Murphy Barbara A. , Alston-Johnson Devena , Mendes Rui Amaral , Beadle Beth Michelle , Jensen Siri Beier , Saunders Deborah P. 
Published: July 2019

PURPOSETo provide guidance regarding best practices in the prevention and management of medication-related osteonecrosis of the jaw (MRONJ) in patients with cancer.METHODSMultinational Association of Supportive Care in Cancer/International Society of Oral Oncology (MASCC/ISOO) and ASCO convened a multidisciplinary Expert Panel to evaluate the evidence and formulate recommendations. Guideline development involved a systematic review of the literature and a formal consensus process. PubMed and EMBASE were searched for studies of the prevention and management of MRONJ related to bone-modifying agents (BMAs) for oncologic indications published between January 2009 and December 2017. Results from an earlier systematic review (2003 to 2008) were also included.RESULTSThe systematic review identified 132 publications, only 10 of which were randomized controlled trials. Recommendations underwent two rounds of consensus voting.RECOMMENDATIONSCurrently, MRONJ is defined by (1) current or previous treatment with a BMA or angiogenic inhibitor, (2) exposed bone or bone that can be probed through an intraoral or extraoral fistula in the maxillofacial region and that has persisted for longer than 8 weeks, and (3) no history of radiation therapy to the jaws or metastatic disease to the jaws. In patients who initiate a BMA, preventive care includes comprehensive dental assessments, discussion of modifiable risk factors, and avoidance of elective dentoalveolar surgery (ie, surgery that involves the teeth or contiguous alveolar bone) during BMA treatment. It remains uncertain whether BMAs should be discontinued before dentoalveolar surgery. Staging of MRONJ should be performed by a clinician with experience in the management of MRONJ. Conservative measures comprise the initial approach to MRONJ treatment. Ongoing collaboration among the dentist, dental specialist, and oncologist is essential to optimal patient care.
La música en la publicidad que atrae a los jóvenes
Authors: Rubio-Romero Juana , Perlado -Lamo de Espinosa Marta , Ramos- Rodriguez Mar 
Published: July 2019

Estudio de las claves de éxito de la música en la publicidad audiovisual que más gusta a los jóvenes universitarios. La investigación se basa en los resultados de un estudio longitudinal que se lleva a cabo en el festival publicitario Jóvenes Tocados por la Publicidad, con distintas categorías de premios. En el artículo se analizan los anuncios nominados y ganadores a la categoría de música-sonido de las últimas diez ediciones (2005-2016) del festival, en total 30 anuncios. Para seleccionar los spots que alcanzan mayor notoriedad entre los jóvenes universitarios y entender el porqué de su selección, se utiliza una metodología triangular, que aplica métodos cuantitativos y cualitativos. Los resultados del estudio confirman el valor y la trascendencia de la música en el éxito de la publicidad audiovisual que más atrae a los jóvenes, observando que existe poca relevancia de la clasificación música original-preexistente en los anuncios escogidos y una mayor incidencia de la categoría diegética-extradiegética. Se evidencia que lo que más valoran los jóvenes en la música de la publicidad es lo que les hace sentir, prefiriendo canciones emotivas, sensibles y con cierta profundidad. Además, este target aprecia que la música en la publicidad sea coherente y adaptada al mensaje de la campaña.
Estudio de casos de la ficción sonora en la radio pública, RNE, y en la plataforma de podcast del Grupo Prisa en España
Authors: López Villafranca Paloma 
Published: July 2019

El cambio en el hábito de consumo de la radio con las nuevas tecnologías y la aparición de creaciones de audio digitales con un formato diferente a los espacios de radio tradicionales han propiciado la proliferación del podcast de ficción en España. Es el caso de los podcasts Negra y criminal y El gran apagón de la plataforma Podium Podcast (Prisa), y la irrupción de formatos novedosos como Tiempo de valientes y Carlos de Gante de rne. El objetivo de esta investigación es realizar un análisis comparativo de estos nuevos formatos. Para ello hicimos un análisis de contenido de estos espacios de ficción de la plataforma española Podium Podcast y de los formatos transmedia de la emisora rne durante la primera temporada de emisión 2016-2017. Comprobamos que los podcasts de rne cumplen la función de complementar las tramas de las series televisivas, el núcleo central del transmedia, con breve duración y basados más en pensamientos y narración que en la acción. Por otra parte, los formatos de Podium, que siguen la fórmula estadounidense con mayor duración, incluyen elementos narrativos que rompen con el tradicional radioteatro y prima la acción frente al relato.
¿De quién es esa voz? Evolución de su presencia y uso por tipo de personaje en la publicidad radiofónica (2009-2016)
Authors: Perelló Oliver Salvador , Muela Molina Clara 
Published: July 2019

El presente trabajo analiza el uso de la voz en la publicidad radiofónica a partir de tres objetivos concretos: cuantificar la presencia de los distintos tipos de voces; analizar la praxis de los anunciantes respecto a la elección de un tipo de voz concreto; y estudiar las formas de identificación del portavoz y su implicación con el producto a través del mensaje. El estudio se basa en dos muestras estadísticamente representativas referidas a los años 2009 y 2016. El análisis pone de manifiesto que son las voces de los consumidores —cuyo peso se ha incrementado en un 52 %— y las propias de los empleados de las empresas —que se han multiplicado por 14— las que más presencia acumulan en las emisiones publicitarias radiofónicas entre los dos años de referencia. El trabajo constata la infrautilización de la radio como medio publicitario, avanzando como consecuencia, entre otros aspectos, el uso incorrecto e ineficaz de la voz para la identificación de determinados personajes que avalan al anunciante y se dirigen a la audiencia en su nombre.
Efektivitas Manajemen Lembaga Pendidikan Islam pada Jurusan PAI Fakultas Tarbiyah UIN Sunan Kalijaga Yogyakarta
Authors: Wibowo Agus 
Published: July 2019

This research aims to investigate the level of effectiveness of the management of Islamic education in the Department of Islamic Education, Faculty of Tarbiyah and Teaching, UIN Sunan Kalijaga Yogyakarta. The focus is on curriculum management component, infrastructure, governance, and public relations. This is a quantitative research using survey as its technique. The subject of this research are the chairman and the secretary of the Department of Islamic Education, 28 professors, administrative staff, and 270 students. The data is collected through observation, documentation, interviews and questionnaire. The data is analyzed using SPSS Program version 2.0. The results showed that in terms of management (1) the curriculum reached high level of effectiveness of 81,29%, (2) the infrastructures also leveled in high category of 80,08%, (3) governance leveled at good (74,13%), and (4) public relations reached high category of 76,88%.
„Klagevehikel“ im deutschen Rechtssystem
Authors: Filusch Tobias , Figge Pia 
Published: July 2019

Zusammenfassung
Im deutschen Rechtssystem lässt sich aktuell zunehmend eine Initiierung von Klagevehikeln feststellen. Dabei werden Schadensersatzansprüche von zum Teil enormer Größenordnungen in einer später als Kläger auftretenden Gesellschaft gesammelt. Das ökonomische Prinzip solcher Klagevehikel sowie begünstigend wirkende Faktoren rechtlicher und wirtschaftlicher Natur werden in diesem Beitrag vorgestellt und diskutiert. Eine Zunahme von davon ausgehenden Gerichtsverfahren, die ganze Wirtschaftsbranchen betrifft, kann im Ergebnis davon abgeleitet werden.
Discrete uniform limit law for additive functions on shifted primes
Authors: Stepanauskas Gediminas , Žvinytė Laura 
Published: July 2019

The sufficient and necessary conditions for a weak convergence of distributions of a set of strongly additive functions fx , x ⩾ 2, the arguments of which run through shifted primes, to the discrete uniform law are obtained. The case when fx (p) ∈ {0, 1} for every prime pis considered.