bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Effectiveness of Biographical Approaches in Long-Term Care: A Systematic Review
Authors: Menn Lara , Corsten Sabine , Lauer Norina , Wallace Sarah J 
Published: May 2019

Abstract

Background and Objectives
Older adults in long-term residential aged care experience loneliness and reduced quality of life (QoL). Biographical approaches use the recall of the past events to increase self-efficacy, promote acceptance, and improve QoL. The aim of the systematic review was to examine the effectiveness of biographical approaches in improving the QoL of older adults in long-term residential aged care.

Research Design and Methods
This systematic review was conducted in accordance with PRISMA guidelines, using databases Medline, CINAHL, and the Cochrane Library. A 2-phase search strategy was used to identify research literature relating to the use of biographical interventions. Narrative analysis was used to synthesize results.

Results
Twenty-one studies met inclusion criteria for this review, comprising both group and individual interventions. The findings were inconsistent. Subjective elements of QoL of older adults improved in a narrow majority of the studies. Of a total of 21 outcomes investigated in group interventions, 11 resulted in significant improvements in QoL. The 16 outcomes of the individual interventions resulted in 10 significant improvements. The most significant influence was observed in life satisfaction. Group reminiscence also had a particularly strong influence on self-esteem.

Discussion and Implications
Although benefits were observed, it remains unclear why some interventions led to improvements in subjective elements of QoL and others did not. Exploration of the participant perspective through qualitative data collection and more detailed description of interventions in future studies could lead to a better understanding of the treatment components that are related to improved outcomes for older adults.
Datastorr: a workflow and package for delivering successive versions of 'evolving data' directly into R
Authors: Falster Daniel S , FitzJohn Richard G , Pennell Matthew W , Cornwell William K 
Published: May 2019

Abstract
The sharing and re-use of data has become a cornerstone of modern science. Multiple platforms now allow easy publication of datasets. So far, however, platforms for data sharing offer limited functions for distributing and interacting with evolving datasets— those that continue to grow with time as more records are added, errors fixed, and new data structures are created. In this article, we describe a workflow for maintaining and distributing successive versions of an evolving dataset, allowing users to retrieve and load different versions directly into the R platform. Our workflow utilizes tools and platforms used for development and distribution of successive versions of an open source software program, including version control, GitHub, and semantic versioning, and applies these to the analogous process of developing successive versions of an open source dataset. Moreover, we argue that this model allows for individual research groups to achieve a dynamic and versioned model of data delivery at no cost.
Tissue-specific sex differences in human gene expression
Authors: Kassam Irfahan , Wu Yang , Yang Jian , Visscher Peter M , McRae Allan F 
Published: May 2019

Abstract
Despite extensive sex differences in human complex traits and disease, the male and female genomes differ only in the sex chromosomes. This implies that most sex-differentiated traits are the result of differences in the expression of genes that are common to both sexes. While sex differences in gene expression have been observed in a range of different tissues, the biological mechanisms for tissue-specific sex differences (TSSDs) in gene expression are not well understood. A total of 30 640 autosomal and 1021 X-linked transcripts were tested for heterogeneity in sex difference effect sizes in n = 617 individuals across 40 tissue types in Genotype–Tissue Expression (GTEx). This identified 65 autosomal and 66 X-linked TSSD transcripts (corresponding to unique genes) at a stringent significance threshold. Results for X-linked TSSD transcripts showed mainly concordant direction of sex differences across tissues and replicate previous findings. Autosomal TSSD transcripts had mainly discordant direction of sex differences across tissues. The top cis-expression quantitative trait loci (eQTLs) across tissues for autosomal TSSD transcripts are located a similar distance away from the nearest androgen and estrogen binding motifs and the nearest enhancer, as compared to cis-eQTLs for transcripts with stable sex differences in gene expression across tissue types. Enhancer regions that overlap top cis-eQTLs for TSSD transcripts, however, were found to be more dispersed across tissues. These observations suggest that androgen and estrogen regulatory elements in a cis region may play a common role in sex differences in gene expression, but TSSD in gene expression may additionally be due to causal variants located in tissue-specific enhancer regions.
Social norm feedback reduces primary care antibiotic prescribing in a regression discontinuity study
Authors: Bradley Declan T , Allen Sarah E , Quinn Helen , Bradley Brenda , Dolan Matthew 
Published: May 2019

Abstract

Background
Reducing antibiotic prescribing is a priority for health authorities responsible for preventing antimicrobial resistance. Northern Ireland has high rates of antimicrobial use. We implemented a social norm feedback intervention and evaluated its impact.

Objectives
To estimate the size and duration of the effect of a social norm feedback letter to GPs who worked in the 20% of practices with the highest antimicrobial prescribing.

Methods
The letter was sent in October 2017 to 221 GPs in 67 practices. To assess the effect of the intervention, we used a sharp non-parametric regression discontinuity (RD) design, with prescribing rates in the four calendar quarters following the intervention as the outcome variables.

Results
In the quarter following the intervention (October to December 2017) there was a change of −25.7 (95% CI = −42.5 to −8.8, P = 0.0028) antibiotic items per 1000 Specific Therapeutic group Age-sex Related Prescribing Units (STAR-PU). At 1 year, the coefficient was −58.7 (95% CI = −116.7 to −0.7, P = 0.047) antibiotic items per 1000 STAR-PU. The greatest change occurred soon after the intervention. Approximately 18900 fewer antibiotic items were prescribed than if the intervention had not been made (1% of Northern Ireland’s annual primary care antibiotic prescribing).

Conclusions
A social norm feedback intervention reduced antibiotic prescribing in the intervention practices. The diminishing effect over time suggests the need for more frequent feedback. The RD method allowed measurement of the effectiveness of an intervention that was delivered as part of normal business, without a randomized trial.
A smart decision: smartphone use for operative data collection in arthroscopic shoulder instability surgery
Authors: Mohr Jill , Strnad Gregory J , Farrow Lutul , Heinlein Kate , Hettrich Carolyn M , Jones Morgan H , Miniaci Anthony , Ricchetti Eric , Rosneck James , Schickendantz Mark , Saluan Paul , Vega Jose F , Spindler Kurt P 
Published: May 2019

Abstract

Objective
This study tested validity, accuracy, and efficiency of the Orthopaedic Minimal Data Set Episode of Care (OME) compared with traditional operative report in arthroscopic surgery for shoulder instability. As of November 2017, OME had successfully captured baseline data on 97% of 18 700 eligible cases.

Materials and Methods
This study analyzes 100 cases entered into OME through smartphones by 12 surgeons at an institution from February to October 2015. A blinded reviewer extracted the same variables from operative report into a separate database. Completion rates and agreement were compared. They were assessed using raw percentages and McNemar’s test (with continuity correction). Agreement between nominal variables was assessed by unweighted Cohen’s kappa and a concordance correlation coefficient measured agreement between continuous variables. Efficiency was assessed by median time to complete.

Results
Of 37 variables, OME demonstrated equal or higher completion rates for all but 1 and had significantly higher capture rates for 49% (n = 18; P &lt; .05). Of 33 nominal variables, raw proportional agreement was ≥0.90 for 76% (n = 25). Raw proportional agreement was perfect for 15% (n = 5); no agreement statistic could be calculated due to a single variable in operative note and OME. Calculated agreement statistic was substantial or better (κ &gt; 0.61) for 51% (n = 17) for the 33 nominal variables. All continuous variables assessed (n = 4) demonstrated poor agreement (concordance correlation coefficient &lt;0.90). Median time for completing OME was 103.5 (interquartile range, 80.5-151) seconds.

Conclusions
The OME smartphone data capture system routinely captured more data than operative report and demonstrated acceptable agreement for nearly all nominal variables, yet took &lt;2 minutes to complete on average.
American Bias in Global Security Studies Data
Authors: Colgan Jeff D 
Published: May 2019

AbstractThree major datasets contain problematic interpretative judgments, arguably biased toward the United States: the Polity dataset; Reiter and Stam's data on war outcomes; and Singh and Way's data on nuclear proliferation. These examples raise the possibility that important datasets in global security studies, and in political science more generally, are systematically affected by an American bias. Bias means that, non-Americans might code the same observations differently, on average. The issue arises because Americans, on average, seem to have certain predispositions that non-Americans, on average, do not have. Other nationalities have their own predispositions. I also demonstrate that each of the three empirical examples has significant implications for causal inferences, altering certain statistical findings based upon them. For instance, I reexamine Haber and Menaldo's study of the resource curse, showing that alternative data coding casts substantial doubt on their inferences.
American Perspectives and Blind Spots on World Politics
Authors: Colgan Jeff D 
Published: May 2019

AbstractScholars of international relations (IR) from the United States, like any country, view the world with particular perspectives and beliefs that shape their perceptions, judgments, and worldviews. These perspectives have the potential to affect the answers to a host of important questions—in part by shaping the questions that get asked in the first place. All scholars are potentially affected by national bias, but American bias matters more than others. This special issue focuses on two issues: attention and accuracy in IR research. While previous scholarship has raised principally normative or theoretical concerns about American dominance in IR, our work is heavily empirical and engages directly with the field's mainstream neopositivist approach. The collected articles provide specific, fine-grained examples of how American perspectives matter for IR, using evidence from survey experiments, quantitative datasets, and more. Our evidence suggests that American perspectives, left unexamined, negatively affect our field's research. Still, the essays in this special issue remain bullish about the field's neopositivist project overall. We also offer concrete steps for taking on the problems we identify, and improving our field's scholarship.
Factual survey of the clinical use of deformable image registration software for radiotherapy in Japan
Authors: Kadoya Noriyuki , Kito Satoshi , Kurooka Masahiko , Saito Masahide , Takemura Akihiro , Tohyama Naoki , Tominaga Masahide , Nakajima Yujiro , Fujita Yukio , Miyabe Yuki 
Published: May 2019

Abstract
Deformable image registration (DIR) has recently become commercially available in the field of radiotherapy. However, there was no detailed information regarding the use of DIR software at each medical institution. Thus, in this study, we surveyed the status of the clinical use of DIR software for radiotherapy in Japan. The Japan Society of Medical Physics and the Japanese Society for Radiation Oncology mailing lists were used to announce this survey. The questionnaire was created by investigators working under the research grant of the Japanese Society for Radiation Oncology (2017–2018) and intended for the collection of information regarding the use of DIR in radiotherapy. The survey was completed by 161 institutions in Japan. The survey results showed that dose accumulation was the most frequent purpose for which DIR was used in clinical practice (73%). Various commissioning methods were performed, although they were not standardized. Qualitative evaluation with actual patient images was the most commonly used method (28%), although 30% of the total number of responses (42% of institutions) reported that they do not perform commissioning. We surveyed the current status of clinical use of DIR software for radiotherapy in Japan for the first time. Our results indicated that a certain number of institutions used DIR software for clinical practice, and various commissioning methods were performed, although they were not standardized. Taken together, these findings highlight the need for a technically unified approach for commissioning and quality assurance for the use of DIR software in Japan.
Imperial Rejuvenations: Youth, Empire, and the Problem of Accelerated Aging in “Tropical” Colonies, ca. 1800–1914
Authors: Pomfret David M 
Published: May 2019

Abstract
In recent years scholars have argued that “rejuvenation” took distinctively modern forms as a specific set of surgical procedures intended to realize sexual potency and libidinal enhancement, as well as anti-aging medicine and cosmetic body projects. However, this article underlines the earlier, imperial dimensions of rejuvenation as a set of modern, state-sponsored practices taking shape outside Europe. An important turning point in the modern history of rejuvenation was a shift around 1830 in thinking about “the tropics,” as scientists who identified heat as accelerating the process of aging rejected the possibility of acclimatization in hot zones. Because racial vitality supposedly diminished more quickly in the tropics, the older ideal of the grizzled, mature colonial soldier fell into decline, and rethinking the globe in racial-climatological terms made youth an essential corequisite of empire. Military commanders confronted the need to rejuvenate armies by recruiting soldiers at younger ages. Together with medical experts, they responded to fears of racial-climatological impotence by developing a range of strategies—from troop rotation to the development of hill stations—which scaled up rejuvenation to the level of entire population groups. Focusing on strategies elaborated in Asia to address this problem, this article shows how ideas about youth, time, geography, and modernity gave rise to spaces and networks designed to slow or reverse the aging process, or in other words to achieve “imperial rejuvenation” well before rejuvenation became a buzzword in late nineteenth-century Europe.
Prosecuting Procurement in the Russian Empire
Authors: Hearne Siobhán 
Published: May 2019

Abstract
Concern about the issue of forced prostitution reached its height in the Russian empire (as elsewhere in Europe and the Americas) at the turn of the twentieth century, as part of the wider international “white slave” panic. In 1909, new antiprocurement statutes were incorporated into the Russian empire’s Criminal Code to ensure that those who forced, coerced, or encouraged young women to enter the commercial sex industry felt the full force of the law. This article uses a case study of the Russian empire’s Estonian provinces (Estliand and Lifliand) to highlight the regional nature of Russian imperial experience. Prosecuting procurement was aligned with the priorities of local government, and the authorities in Revel’ (Tallinn) and Iu’rev (Tartu) used the issue of procurement to bolster their revenue. Here, the statutes gave the authorities additional tools for targeting individuals, such as managers of unlicensed brothels, who deprived the government of the income it generated from regulating the commercial sex industry. Drawing on court cases from the early 1910s, this article also examines the interaction of lower-class people with the state, their engagement with the legal system, their knowledge of the law, and the rhetorical strategies they employed to in their attempts to secure specific outcomes.
Preoperative Evaluation of the Cardiac Surgical Patient
Authors: Gerlach Rebecca M. 
Published: May 2019

Abstract
Patients undergoing cardiac surgery are at elevated risk for perioperative complications; however, certain risk factors may be modifiable. Preoperative evaluation performed in advance of surgery provides an opportunity for the perioperative anesthesiologist to intervene to reduce risk. Performing a focused history and physical examination informs the selection of appropriate preoperative tests. Risk assessment via tools specific to cardiac surgery provide a detailed risk profile. Certain diseases common to cardiac surgical patients deserve particular focus during assessment. Poorly controlled diabetes mellitus and resultant hyperglycemia are modifiable risk factors. Undiagnosed obstructive sleep apnea is common and associated with postoperative complications. Concurrent carotid artery disease presents a management conundrum requiring multidisciplinary planning. Preoperative anemia is common; when due to iron deficiency, it is easily treated to improve outcomes. In addition to gathering information about the patient, the goal of preoperative evaluation is to identify ways to reduce risk and improve outcome from surgery in a resource-efficient manner.
Cardiac Tumors
Authors: Kozarek Katherine , Hood Ryan 
Published: May 2019

Abstract
Cardiac tumors are rarely encountered in clinical practice; however, because they affect vital structures, they can have significant consequences. Cardiac tumors are categorized as either primary tumors originating from cardiac tissue or metastatic tumors migrated from other sites; they may infiltrate the atria, ventricles, valves, and coronary arteries, resulting in considerable changes to normal physiology. They may extend beyond the myocardium to the pericardium, great vessels, and mediastinum. Advances in the development of imaging modalities have allowed for expedited diagnostic evaluation of cardiac tumors. Prompt treatment, which often includes surgical intervention, is essential to both alleviate symptoms and prevent harmful sequelae. The intraoperative anesthetic management of a patient with a cardiac mass presents a number of challenges due to altered cardiovascular physiology. Because these tumors occur so infrequently, standardized, evidence-based diagnostic and treatment guidelines have not been developed. The existing data were derived mainly from small case series and case reports. The aggressive nature of the disease warrants further investigation to improve the accuracy of diagnostic modalities and the efficacy of treatment regimens.
Air Embolism on Cardiopulmonary Bypass
Authors: Hudson Aaron , Hood Ryan 
Published: May 2019

Abstract
The danger associated with air embolism in cardiac surgery has been well established for over 125 years. In the first volume of Annals of Surgery, published in 1885, long preceding the era of cardiac surgery and the use of extracorporeal circulatory techniques, Dr. Nicholas Senn alluded to the ensuing calamity caused by air embolism: “I intend on this occasion to call your attention to one of the most dreaded and, I may add, one of the most uncontrollable causes of sudden death—I allude to air-embolism.”1,2 Since the advent of modern cardiac surgery, much attention has been focused on the prevention of air embolism by cardiac surgeons, anesthesiologists, and perfusionists alike. Indeed, all three team members are critically responsible for the safe conduct of thousands of cardiac surgical procedures occurring on a daily basis worldwide. While the morbidity and mortality of massive air embolism is exceedingly high, most believe that with appropriate training and unwavering vigilance during clinical practice, almost all massive air emboli can be prevented.3
Cardiac Implantable Electronic Device Lead Extractions
Authors: Fitzmartin Kevin , Kacha Aalok 
Published: May 2019

Abstract
Cardiac implantable electronic devices (CIEDs) are used for an increasing range of indications. With a broader range of indications, CIEDs are being implanted in increasing numbers. They are being used in older patients as well as patients with more comorbidities. As expected with these trends, the need for device extraction for a variety of reasons has steadily grown as well. These leads can often be removed via simple traction, but other techniques have been developed for circumstances where removal is more complex. To perform this procedure safely, a team-based approach is required, as is the ability to anticipate consequences of complications for each of the different methods of removal. A gold standard method has not been identified for transvenous lead extraction, but rather one has a toolbox of methods at their disposal. In this chapter, indications for lead removal, extraction techniques and devices, as well as potential complications are reviewed.
Minimally Invasive Esophagectomy
Authors: Merling Brandon , Dupont Frank 
Published: May 2019

Abstract
Esophageal cancer is the eighth most common malignancy worldwide, producing a high morbidity and mortality rate around the globe. Minimally invasive esophagectomy (MIE) is most commonly performed on patients with this devastating disease. Esophagectomy is a high-risk procedure, and perioperative mortality remains around 5%–8%. Because esophageal cancer is associated with chronic alcohol and tobacco use, patients have serious comorbid conditions that affect anesthetic management and perioperative care. Among them, pulmonary complications and anastomotic failure remain the most common causes of perioperative morbidity and mortality. The anesthesiologist managing a patient during MIE must be able to reduce the effect of the patient’s multiple comorbidities intraoperatively while mitigating the factors that lead to adverse postoperative outcomes.
Anesthesia for Lung Transplantation
Authors: Roberts J. Devin 
Published: May 2019

Abstract
Since the first human procedure in 1963, lung transplantation has become the gold standard treatment of a variety of end-stage lung diseases. With over 4000 lung transplants performed in 2015 and steadily improving survival rates over the past three decades, anesthetic management of patients undergoing lung transplant can significantly contribute to patient outcomes. Anesthesia care for lung transplantation can be both complex and clinically challenging. Anesthesiologists taking part in these procedures need to have specific skills regarding thoracic and cardiac anesthesia. There are both technical and physiological challenges, such as achieving adequate lung isolation and oxygenation, interpretation and use of transesophageal echocardiography, and the management of respiratory and myocardial impairments. This chapter provides an overview of these perioperative anesthetic management considerations utilizing a problem-based format.