bluuebunny/crossref_metadata_2025_split huggingface dataset:
Are family relations connected to the quality of the outcome in adolescent anorexia nervosa? An observational study with the Lausanne Trilogue Play
Authors: Balottin Laura , Mannarini Stefania , Mensi Martina Maria , Chiappedi Matteo , Balottin Umberto 
Published: July 2018

The study aims to explore the connection between the family interactive patterns, investigated with a standardized observational tool based on a recorded play session, the Lausanne Trilogue Play, and the outcome of adolescent patients with anorexia nervosa after a 6 months treatment, based on the Morgan–Russel Outcome Assessment Schedule. Seventy‐two parents and adolescent daughters with anorexia nervosa, consecutively referred to an adolescent neuropsychiatric service, participated in the study and underwent an integrated model of treatment, based on constant neuropsychiatric and dietary monitoring, weekly individual psychotherapy for the daughter, and parental counselling and support. A better adolescents' functioning in family relationships, in particular in the triadic ones, at first assessment, was associated with a better outcome. Data on family interactions may help predict the most appropriate intervention for the patient and his family.
Adverse Events Associated With PCSK9 Inhibitors: A Real‐World Experience
Authors: Gürgöze Muhammed T. , Muller‐Hansma Annemarie H.G. , Schreuder Michelle M. , Galema‐Boers Annette M.H. , Boersma Eric , Roeters van Lennep Jeanine E. 
Published: July 2018

In randomized clinical trials (RCTs) proprotein convertase subtilisin/kexin 9 (PCSK9) inhibitors showed a favorable safety profile, however, “real‐world” data on adverse events (AEs) is scarce. Three datasets, a hospital registry (n = 164), and two Pharmacovigilance databases, Lareb (n = 149) and VigiLyze (n = 15,554), reporting AEs attributed to PCSK9 inhibitors (alirocumab or evolocumab) prescribed in clinical practice were analyzed. In the hospital registry, 41.5% of the patients reported any AE, most often injection‐site reactions (33.8%) and influenza‐like illness (27.9%). Twelve patients (7%) discontinued PCSK9 inhibitor treatment. Most common AE reported in the Lareb and VigiLyze database was myalgia (12.8% and 8.3%, respectively). No clinically relevant differences in gender or between drugs were observed. No specific subgroup of patients could be identified at risk of developing AEs. During follow‐up, AEs resolved in most patients (71.1%). In a real‐world setting, PCSK9 inhibitors are well tolerated with an overall safety profile comparable to RCTs.
Study of factors related to the attitudes toward studying abroad among preclinical/clinical undergraduate dental students at three dental schools in Japan
Authors: Oka Hiroko , Ishida Yoko , Hong Guang 
Published: July 2018

AbstractDespite of their general interests in studying abroad, there are two types of dental student in Japan. They are those who decide to go studying abroad and those who do not. The aim of this study was to clarify the factors related to the attitudes toward studying abroad among preclinical/clinical undergraduate dental students who attended three dental schools in Japan. A questionnaire was used to assess undergraduate dental students' attitudes toward studying abroad. We analyzed the differences between junior (preclinical) students and senior (clinical) students on concerns, and relationships between personality traits based on the Big Five and experiences related to studying abroad. Four hundred and thirty‐nine undergraduate students completed the questionnaire. The senior dental students were more worried, more than the junior students, about “lack of language ability in daily life,” “higher quality facilities and environment,” and valued “dental/medical knowledges and skills” and “advantage for getting a job” through studying abroad. Both junior and senior students with experience of/plans for studying abroad reported significantly higher levels of openness to experience than those without such experiences or plans. The less‐open group was more concerned with “lack of language ability in daily life/academic fields,” “higher quality facilities and environment,” “life in a foreign country,” “interpersonal relationships in foreign countries,” and “no friends in foreign countries” than the open‐group. Although the preclinical and clinical dental students at the three dental schools in Japan had different views of concern for studying abroad, “openness to experience” might be a common key factor related to their studying abroad. However, apart from any personality factor, alleviating students' concerns regarding daily life adjustments might be effective in promoting a willingness to go studying abroad.
Realizing High‐Performance Li–Polysulfide Full Cells by using a Lithium Bis(trifluoromethanesulfonyl)imide Salt Electrolyte for Stable Cyclability
Authors: Ahad Syed Abdul , Pitchai Ragupathy , Beyene Anteneh Marelign , Joo Sang Hoon , Kim Do Kyung , Lee Hyun‐Wook 
Published: July 2018

AbstractSince concentrated electrolytes have attracted great attention for the stabilization of lithium‐metal anodes for lithium‐ion batteries, the demonstration of a full cell with an electrolyte concentration study has become a research topic of interest. Herein, we have demonstrated a proof of concept, a lithium–polysulfide full cell battery using various lithium bis(trifluoromethanesulfonyl)imide (LiTFSI) electrolyte concentrations with glass‐fiber‐based composite and hard carbon as the cathode and anode, respectively. The initial capacity of the lithium‐polysulfide full cell is found to be 970 mA h g−1 at 0.1 C. The capacity is stabilized at 870 mA h g−1 after 100 cycles with a capacity retention of 88.6 %. An excellent capacity retention of ≈80 % is achieved after long 800 cycles at 0.5 C by using full cell technology. Further, our post‐mortem analysis sheds light on the difference in SEI layer formation on hard carbon anodes with changing electrolyte concentration, thereby indicating reasons for the obtainment of a high cyclic performance with 1 m LiTFSI salt electrolyte. The successful demonstration of the long cyclic performance of Li–polysulfide full cells is indeed a step towards producing high performance Li–polysulfide full cell batteries with long cycling using conventional LiTFSI salt electrolyte and commercial anode materials.
Hadoop‐based analytic framework for cyber forensics
Authors: Chhabra Gurpal Singh , Singh Varinderpal , Singh Maninder 
Published: July 2018

SummaryWith an exponential increase in the data size and complexity of various documents to be investigated, existing methods of network forensics are found not much efficient with respect to accuracy and detection ratio. The existing techniques for network forensic analysis exhibit inherent limitations while processing a huge volume, variety, and velocity of data. It makes network forensic a time‐consuming and resource‐consuming task. To balance time taken and output delivered, these existing techniques put a limit on the amount of data under analysis, which results in a polynomial time complexity of these solutions. So to mitigate these issues, in this paper, we propose an effective framework to overcome the limitation to handle large volume, variety, and velocity of data. An architectural setup that consists of MapReduce framework on top of Hadoop Distributed File System environment is proposed in this paper. The proposed framework demonstrates its capability to handle issues of storage and processing of big data using cloud computing. Also, in the proposed framework, supervised machine learning (random forest‐based decision tree) algorithm has been implemented to demonstrate better sensitivity. To train and validate the model, online available data set from CAIDA is taken and university network traffic samples, with increasing size, has been taken for experiment. Results thus obtained confirm the superiority of the proposed framework in network forensics, with an average accuracy of 99.34% (malicious and nonmalicious traffic).
The new guidelines of Papanicolaou Society of Cytopathology for respiratory specimens: Assessment of risk of malignancy and diagnostic yield in different cytological modalities
Authors: Canberk Sule , Montezuma Diana , Aydın Ozlem , Demirhas Mehmet Polat , Denizci Barkın , Akbas Meryem , Caliskan Can , Tokat Fatma , Ince Umit , Schmitt Fernando 
Published: July 2018

BackgroundIn 2016, the Papanicolaou Society of Cytopathology (PSC) issued a new classification scheme for respiratory cytology. We aim to evaluate our samples according to this classification and to assess risk of malignancy and diagnostic yield of different cytological modalities.MethodsRespiratory specimens (sputum, bronchial wash/brush, BAL and FNA) obtained between 2007 and 2016 were reclassified according to PSC guidelines. Risk of malignancy for each diagnostic category was determined. Diagnostic yield was evaluated based on three‐categorical approach.ResultsOne thousand, two hundred and ninety respiratory specimens were retrieved, of which 280 had histologic follow‐up. Samples were reclassified as nondiagnostic 16%, negative for malignancy 53%, atypical 5.4%, neoplastic (benign neoplasm/low‐grade carcinoma) 0.4%, suspicious for malignancy 2.1% and malignant 23.1%. Risk of malignancy for each category was 64.01% for ND, 48.27% for NM, 59.09% for A, 100% for N‐B‐LG; 90% for SM and 89.74% for M. When only malignant cases were considered positive tests, cytology sensitivity was 55% and specificity 88%.ConclusionOur results were in line with PSC guidelines, but the use of multiple cytological techniques may cause some discrepancies in overall diagnostic yield and in estimated risks of malignancy, which is important due to the widespread utilization of different cytological procedures.
Coinfection of Sarcina ventriculi and Candida in a patient of gastric outlet obstruction: An overloaded pyloric antrum
Authors: Aggarwal Shikha , Tyagi Ruchita , Selhi Pavneet Kaur , Garg Avantika , Sood Ajit , Sood Neena 
Published: July 2018

AbstractSarcina ventriculi is a rare gram‐positive, anaerobic bacteria, associated with delayed gastric emptying. We report a case of a 45‐year‐old lady, who presented with features of gastric outlet obstruction, and coinfection of S. ventriculi and Candida was detected on examining gastric brushings and biopsy. S. ventriculi is identified by its peculiar configuration in the form of tetrads and octets. Coexistence of S. ventriculi with other organisms is highly unusual.
From fad to FAD: A theoretical formulation and proposed name change for “drunkorexia” to food and alcohol disturbance (FAD)
Authors: Choquette Emily M. , Rancourt Diana , Kevin Thompson J. 
Published: July 2018

Abstract“Drunkorexia” is a term that has been used to describe behaviors such as restricting food intake in anticipation of alcohol consumption to offset total caloric intake, and/or to enhance the intoxicating effect of alcohol consumption. Scattered studies over the past few years have indicated the potential problematic nature of the intersection of these behaviors, yet there remain significant gaps in the operationalization of the construct, limiting research progress. In this article, we articulate limitations of the current research, including problems with the definition of the construct and a lack of theoretical guidance. We suggest a broader and more accurate phrase to guide future work with this phenomenon: Food and alcohol disturbance (FAD). Additionally, we suggest adapting Fairburn's transdiagnostic theoretical model for FAD. It is hoped these changes might provide a roadmap for future work in this area on risk factors and adaptations of current preventive and treatment approaches to focus on this emerging form of eating disturbance.
Protein‐losing enteropathy in an adult with non‐ischaemic cardiomyopathy: complete reversal by heart transplantation
Authors: Melenovsky Vojtech , Kubanek Milos , Kacer Petr 
Published: July 2018

AbstractProtein‐losing enteropathy (PLE) due to leakage of lymph into the gut sometimes occurs in young patients after Fontan palliation but is very rarely reported with other aetiologies of chronic heart failure (HF). PLE leads to severe hypoalbuminemia and immunodeficiency and is associated with poor prognosis. The mechanisms and the predispositions to PLE are poorly understood. Here, we report an adult patient with advanced HF due to non‐ischaemic non‐dilated hypocontractile cardiomyopathy who developed severe PLE, probably owing to increased ventricular stiffness and constraint by atypically placed epicardial electrode encircling both ventricles. Importantly, both PLE and immunodeficiency completely resolved after heart transplantation.
The power of nonviolence: Confirming and explaining the success of nonviolent (rather than violent) political movements
Authors: Orazani S. Nima , Leidner Bernhard 
Published: July 2018

AbstractDrawing on literatures on social movements and collective action, mentalization, and morality, four studies investigated whether a social movement's use of nonviolence can increase people's willingness to support and join the movement. In a correlational study with a nested design, across 23 movements perceived use of nonviolence predicted participants' willingness to support and join the movement (Study 1, n = 203). This effect was also found experimentally, with Americans supporting nonviolent movements more than violent ones, in hypothetical and real foreign countries (Study 2 and 3, ns = 606 and 373). Study 4 (n = 247) replicated the effects in participants' own country. The effects were transmitted by attribution of mental states to nonviolent movements and subsequent greater perceived morality (Study 2–4). This research demonstrates that nonviolence can benefit social movements in terms of support and mobilization potential, and that these benefits are rooted in perceptions of mental capacity, humanness, and morality.
Determination of ligand efficiency indices in a group of 7H‐purine‐2,6‐dione derivatives with psychotropic activity using micellar electrokinetic chromatography
Authors: Bajda Marek , Chłoń‐Rzepa Grażyna , Żmudzki Paweł , Czopek Anna , Stanisz‐Wallis Krystyna , Łątka Kamil , Pawłowski Maciej , Zagórska Agnieszka 
Published: July 2018

AbstractDiscovering hit compounds and optimization processes in medicinal chemistry nowadays could be improved by predictive tools, based on the relationship between structure of molecules and lipophilic properties. Lipophilicity of drug candidate can affect both the pharmacokinetic and pharmacodynamics properties, in particular, the ability of a molecule to cross the cell membrane. Among the new methods for determination of the lipophilicity of compounds, micellar electrokinetic chromatography (MEKC) is considered to be an appropriate one for bioactive molecules, as it closely mimics the physiological conditions. In this paper MEKC was used for the estimation of the lipophilicity of 24 derivatives of 8‐alkoxy‐7H‐purine‐2,6‐dione, designed and synthesized as potential antidepressant/anxiolytic and antipsychotic agents. The results of experimental method were compared with calculated in silico parameters (AlogPs and milogP by Virtual Computational Laboratory website, log PPallas by Pallas 3.1, Mlog P by Marvin, log PChemS by ChemSketch, log PChemDraw by ChemBioUltra) using Principal Component Analysis (PCA) method. Finally, using estimated log P values for selected compounds ligand – lipophilicity efficiency (LLE), per cent efficiency index (PEI), and binding efficiency index (BEI) parameters were calculated. Applied MEKC procedure could be used for selection of potential lead structure in a group of 7H‐purine‐2,6‐dione derivatives.
Late Quaternary uplift across northwest Luzon Island, Philippines constrained from emergent coral reef terraces
Authors: Maxwell Kathrine V. , Ramos Noelynna T. , Tsutsumi Hiroyuki , Chou Yu‐Chen , Duan Fucai , Shen Chuan‐Chou 
Published: July 2018

AbstractEmergent coral reef terraces in northwest Luzon Island, Philippines are studied to understand relative sea level (RSL) changes and uplift along the Manila Trench forearc region during the Late Quaternary. Coral reef sequences in Currimao, Badoc, and Badoc Island were mapped and were described based on geomorphological characteristics, elevation patterns, and ages. The lower emergent coral reef terraces, which are dated Holocene, are subdivided into three to possibly four terrace steps (TI–TIV in ascending order) with the highest terrace (TIII–TIV) rising up to ~7–9 m amsl. The well‐preserved staircase morphology and meter‐scale terrace risers possibly imply episodes of abrupt RSL changes that resulted from coseismic uplift during the mid‐Holocene. Around 6.8 kyr BP, ~3 m of rapid uplift (possibly coseismic) is inferred to account for the vertical separation of TI (6.2 kyr BP at 3.5 m amsl) and TII (6.8 kyr BP at 6.6 m amsl) in Currimao site. A subsequent episode of RSL fall occurred at 6 kyr BP, based on dated coral samples, and has emerged the lowest terraces in the study sites. New geomorphic and radiometric data suggest that the mid‐Holocene sea level highstand in northwest Luzon occurred at around 7–6 kyr BP. From the elevation and thorium‐230 age of dated terrace surfaces, we estimated Holocene uplift rates from 0.17 ± 0.12 to 0.82 ± 0.15 mm/yr across the three study sites. The estimated uplift rates of northwest Luzon are relatively lower than the uplift rates reported in similar tectonically active regions of the west Pacific such as Papua New Guinea, Taiwan, New Zealand, and Japan. The geomorphological characteristics and age of emergent coral reef terraces reported in this study offer insights on the preservation of long‐term deformation along the northwest Luzon coastal plain that is bordered by a subduction zone and upper‐plate faults. © 2018 John Wiley & Sons, Ltd.
The role of economic uncertainty in forecasting exchange rate returns and realized volatility: Evidence from quantile predictive regressions
Authors: Christou Christina , Gupta Rangan , Hassapis Christis , Suleman Tahir 
Published: July 2018

AbstractIn this paper, we investigate whether the news‐based measure of economic policy uncertainty (EPU) can be used to forecast exchange rate returns and volatility using a quantile regression approach, which accounts for persistence and endogeneity, using data from 13 different countries. Our main findings suggest that: (i) EPU is useful for forecasting exchange rate returns and volatility, (ii) forecasting ability–quantile order relationships exhibit a U‐shape, possibly asymmetric form around the median; and (iii) asymmetries are more pronounced in the case of forecasting volatility.
Effect of cooking treatments on the phytochemical composition and antidiabetic potential of Vernonia amygdalina
Authors: Tekou Florian Amel , Kuate Dieudonne , Nguekouo Philippe Tekem , Woumbo Cerile Ypolyte , Oben Julius Enyong 
Published: July 2018

AbstractThe present study aimed at evaluating the effects of domestic culinary treatment on phytochemical contents (phenolic content and dietary fiber), and the antidiabetic potential of Vernonia amygdalina in type 2 diabetic rats. The culinary forms implied boiling leaves of V. amygdalina directly and eliminating the leaves’ bitterness before boiling. Seventy wistar rats were artificially induced with type 2 diabetes using streptozotocin and high‐fat diet. They then received by oral intubation powders of different culinary forms of leaves extract or suspensions of V. amygdalina at a dose of 500 mg /kg for a period of 4 weeks. The crude fiber, total phenol contents and the DPPH scavenging ability of these culinary forms were also measured and the results showed that values of these parameters were higher in the unwashed form than the washed form. The washed and unwashed forms of V. amygdalina significantly reduced (p < 0.05) the blood glucose, the total cholesterol, triglyceride, transaminases, urea and creatine levels. Aqueous extract has the highest ability to reduce the blood glucose level (75.76%) followed by the unwashed form (61.17%) which was greater than that of the washed form. Also, these forms significantly increased serum HDL cholesterol and total protein level, with the highest activity obtained with the unwashed form. Washing the V. amygdalina leaves (that consists of multiple trituration of leaves with water) contributes to the reduction of antidiabetic and antioxidant properties.
Characterization of protein isolate from Sesamum indicum seed: In vitro protein digestibility, amino acid profile, and some functional properties
Authors: Fasuan Temitope O. , Gbadamosi Saka O. , Omobuwajo Taiwo O. 
Published: July 2018

AbstractThis work evaluated the impacts of pH and sodium chloride (NaCl) concentration on some functional properties, in vitro protein digestibility, and amino acid profile of sesame (Sesamum indicum) protein isolate (SPI) produced using simultaneous recovery of protein and oil technique. The emulsion activity index (EAI), foam capacity (FC), and protein solubility varied with pH and ionic ability. Foam capacity rose with an increase in ionic strength. Protein solubility ranged from 8.39% at pH 4 to 55.08% at pH 10. In vitro protein digestibility of the SPI with pepsin–pancreatin enzyme systems was 89.57%. Amino acid profile showed that essential amino acids constituted 39.48%. The amino acids had good scores well above 50%. The results showed that SPI extracted by aqueous technique could be used as food ingredient, particularly as thickener, binder, and ingredient in baked food products.
Determination of citric acid pretreatment effect on nutrient content, bioactive components, and total antioxidant capacity of dried sweet potato flour
Authors: Kuyu Chala G. , Tola Yetenayet B. , Mohammed Ali , Ramaswamy Hosahalli S. 
Published: July 2018

AbstractOrange flashed sweet potatoes are rich and inexpensive source of diet and antioxidants. The purpose of this study was to evaluate the effects of CA pretreatments and convective hot air drying temperature on proximate composition, bioactive components, and total antioxidant capacity of flour of five orange flashed sweet potato varieties. Moisture, protein, ether extract, ash, carbohydrate, fiber, β‐carotene, total phenolic compounds, and total antioxidant capacity in the dried flour samples were evaluated and reported in the range of 4.1–7.4%, 2.4–4.2%, 1.2–1.1.8%, 2.2–3.2%, 82.7–87.1%, 1.3–1.8%, 35.5–91.6 mg/100 g, 49.8–107.9 mg GAE/100 g, and 27.3–85.4%, respectively. The interaction effects of varieties, drying temperature, and CA concentration were significant (p ˂ 0.05) except for fiber. Kulto and SPK006/6/6 performed better for most of the parameters studied followed by SPK00/06. For almost all varieties, samples dried at 55°C and after treated in 3% CA solution had the highest percentage in terms of proximate composition, bioactive components, and total antioxidant capacities.