bluuebunny/crossref_metadata_2025_split huggingface dataset:
Vti1b promotes TRPV1 sensitization during inflammatory pain
Authors: Sondermann Julia R. , Barry Allison M. , Jahn Olaf , Michel Niklas , Abdelaziz Reham , Kügler Sebastian , Gomez-Varela David , Schmidt Manuela 
Published: October 2018

Abstract
Sensitization of the transient receptor potential ion channel vanilloid 1 (TRPV1) is critically involved in inflammatory pain. To date, manifold signaling cascades have been shown to converge onto TRPV1 and enhance its sensitization. However, many of them also play a role for nociceptive pain, which limits their utility as targets for therapeutic intervention. Here, we show that the vesicle transport through interaction with t-SNAREs homolog 1B (Vti1b) protein promotes TRPV1 sensitization upon inflammation in cell culture but leaves normal functioning of TRPV1 intact. Importantly, the effect of Vti1b can be recapitulated in vivo: Virus-mediated knockdown of Vti1b in sensory neurons attenuated thermal hypersensitivity during inflammatory pain without affecting mechanical hypersensitivity or capsaicin-induced nociceptive pain. Interestingly, TRPV1 and Vti1b are localized in close vicinity as indicated by proximity ligation assays and are likely to bind to each other, either directly or indirectly, as suggested by coimmunoprecipitations. Moreover, using a mass spectrometry–based quantitative interactomics approach, we show that Vti1b is less abundant in TRPV1 protein complexes during inflammatory conditions compared with controls. Alongside, we identify numerous novel and pain state-dependent binding partners of native TRPV1 in dorsal root ganglia. These data represent a unique resource on the dynamics of the TRPV1 interactome and facilitate mechanistic insights into TRPV1 regulation. We propose that inflammation-related differences in the TRPV1 interactome identified here could be exploited to specifically target inflammatory pain in the future.
A Pilot, Randomized Clinical Trial of Bedtime Doses of Prazosin Versus Placebo in Suicidal Posttraumatic Stress Disorder Patients With Nightmares
Authors: McCall William Vaughn , Pillai Anilkumar , Case Doug , McCloud Laryssa , Nolla Tiffany , Branch Fallon , Youssef Nagy A. , Moraczewski Jason , Tauhidul Liniya , Pandya Chirayu D. , Rosenquist Peter B. 
Published: October 2018

Abstract

Purpose/Background
Observational studies show an association between nightmares and suicide. Prazosin is proposed as a nightmare treatment. This pilot, randomized clinical trial tested whether treatment of nightmares with prazosin would reduce suicidal ideas in suicidal posttraumatic stress disorder (PTSD) patients.

Methods/Procedures
Twenty adult, suicidal PTSD patients with nightmares were blindly and randomly assigned 1:1 to escalating doses of prazosin versus placebo at bedtime only for 8 weeks. All participants had comorbid mood disorders and received stable doses of mood disorder medication. Outcomes of interest were measured weekly and included severity of suicidal ideation, nightmares, PTSD, insomnia, and depression. Longitudinal mixed-effects models assessed change in outcomes over time.

Findings/Results
All psychometric measures improved over 8 weeks. However, nighttime measures of nightmares and insomnia showed significantly less improvement in the prazosin group, whereas there was no significant change in daytime measures of suicidal ideation and daytime-only PTSD symptoms. Two patients required emergency psychiatric hospitalization, but there were no suicide attempts and no deaths.

Implications/Conclusions
This study confirmed an effect of nighttime-only prazosin on nighttime symptoms of insomnia and nightmares in suicidal PTSD patients who are experiencing nightmares. Surprisingly, the effect was in the direction opposite of what we expected. Furthermore, prazosin showed no signal on daytime measures including suicidal ideation. The results do not support a larger study of nighttime-only prazosin in suicidal PTSD patients but leave open the possibility of benefit from daytime administration of prazosin.
Perception Versus Reality: Estimated and Actual Online Content Consumption Comparisons and Relationships to Classroom Performance
Authors: Richardson Michael V. , Bliss Rebecca , Welton Wade , Papa Evan 
Published: October 2018

Introduction.
As students and faculty are increasingly becoming more comfortable with technology, physical therapy programs are using the flipped classroom (FC) to provide an environment more conducive to active and problem-based learning. Most literature on students in graduate level health care professional programs rely on subjective student report. To our knowledge, no studies have compared objective actual student consumption of online content to subjective student perception of online content consumption. Nor have studies explored the relationship between actual online content consumption and classroom performance. In this study, we compared estimated and actual online content consumption as well as its relationship to student performance. We hypothesized that students would inaccurately estimate online content viewing amounts and that a positive correlation would exist between online content consumption and student performance.

Methods.
Upon completion of a patient mobility training course, 46 year-one physical therapist students estimated their weekly online content consumption. In this cross-sectional study design, we compared these estimations with student usage data provided by an online learning management system. Additionally, we compared examination grades and overall course grades to average weekly viewing times. A Pearson's product moment correlation assessed the relationship between weekly viewing time and student performance. Discriminant ability of weekly viewing time was assessed with receiver operating characteristic curve analyses.

Results.
At least 40% of the students overestimated their online consumption. Students overestimated their weekly viewing by 63.2%. Weekly viewing time was correlated with percentile class ranks.

Discussion and Conclusion.
Students chronically overestimated online content consumption. Physical therapy faculty should be aware of discrepancies between objective actual and subjective perceived consumption of online content and may consider implementing an open feedback loop relative to actual preparation for the FC since this study also found a positive relationship between weekly viewing time and student performance.
Parametric Covariability in the Standard Model of the Saccadic Main Sequence
Authors: Busettini Claudio , Christy Jennifer Braswell 
Published: October 2018

SIGNIFICANCE
Saccades present a direct relationship between the size of the movement (SACSIZE) and its peak velocity (SACPEAK), the main sequence, which is traditionally quantified using the model SACPEAK = V
max × (1 − e
−SACSIZE/SAT). This study shows that V
max and SAT are not veridical indicators of saccadic dynamics.

PURPOSE
Alterations in saccadic dynamics are used as a diagnostic tool. Are the 95% reference ranges (RRs) of V
max and SAT correctly quantifying the variability in saccadic dynamics of a population?

METHODS
Visually driven horizontal and vertical saccades were acquired from 116 normal subjects using the Neuro Kinetics Inc. Concussion Protocol with a 100-Hz I-Portal NOTC Vestibular System, and the main sequence models were computed.

RESULTS
The 95% RRs of V
max, the asymptotic peak velocity, and SAT, the speed of the exponential rise toward V
max, were quite large. The finding of a strong correlation between V
max and SAT suggests that their variability might be, in part, a computational interaction. In fact, the interplay between the two parameters greatly reduced the actual peak velocity variability for saccades less than 15°. This correlation was not strong enough to support the adoption of a one-parameter model, where V
max is estimated from SAT using the regression parameters. We also evaluated the effects of interpolating the position data to a simulated acquisition rate of 1 kHz. Interpolation had no effect on the population average of V
max and brought a decrease of the average SAT by roughly 8%.

CONCLUSIONS
The 95% RRs of V
max and SAT, treated as independent entities, are not a veridical representation of the variability in saccadic dynamics inside a population, especially for small saccades. We introduce a novel three-step method to determine if a data set is inside or outside a reference population that takes into account the correlation between V
max and SAT.
Case Series: Bilateral Homonymous Visual Field Defects Due to Bilateral Ischemic Strokes
Authors: Papageorgiou Eleni , Anthis Nikolaos , Stathi Theodora , Tsironi Evangelia , Asproudis Ioannis 
Published: October 2018

SIGNIFICANCE
Bilateral strokes are rare and should be considered when patients present with bilateral visual field loss characterized by patterns consistent with right and left-sided homonymous visual field defects. Perimetry, dilated funduscopy, and immediate neuroimaging are mandatory for diagnosis, because patients may present with vague symptoms. These cases reflect the retinotopic features of the striate cortex.

PURPOSE
The purposes of this study were to describe the unusual presentation of bilateral homonymous visual field defects in three patients with bilateral ischemic strokes and to discuss the clinical and neuroanatomical correlations.

CASE REPORTS
Neuro-ophthalmological examination including perimetry and brain magnetic resonance imaging (MRI) was performed in three patients with bilateral homonymous scotomas. Two of three patients presented with superior altitudinal hemianopia, resulting from right and left homonymous superior quadrantanopia due to bilateral occipital strokes below the calcarine fissure. A 57-year-old man (patient 1) with a history of atrial fibrillation presented with driving difficulties. Perimetry revealed bilateral superior altitudinal hemianopia. Brain MRI demonstrated a subacute right occipital stroke and a chronic left occipital stroke, both inferior to the calcarine fissure. An 83-year-old woman (patient 2) presented with reading disorders. Perimetry showed a left incomplete homonymous hemianopia and a right horizontal wedge-shaped homonymous scotoma. Brain MRI showed a chronic ischemic stroke in the left occipital lobe and acute ischemia in the right thalamus. A 40-year-old man (patient 3) was referred with headache, disorientation, and bilateral blurry vision. Perimetry showed bilateral superior altitudinal hemianopia, and MRI demonstrated acute bilateral occipital ischemia. Patients 1 and 2 suffered sequential bilateral strokes and were not aware of the initial scotoma, whereas patient 3 presented with bilateral concurrent strokes.

CONCLUSIONS
Bilateral homonymous visual field defects due to bilateral strokes are rare. Patient history, a careful neuro-ophthalmological examination, and correlation of visual field defect patterns with neuroimaging should prompt the clinician to the presence of this unique entity.
Unwanted Astigmatism and High-order Aberrations One Year after Excimer and Femtosecond Corneal Surgery
Authors: Bohac Maja , Koncarevic Mateja , Dukic Adrijana , Biscevic Alma , Cerovic Vesna , Merlak Maja , Gabric Nikica , Patel Sudi 
Published: October 2018

SIGNIFICANCE
Small incision lenticule extraction (SMILE) is advanced as the most minimally invasive and least traumatic corneal procedure for correcting refractive errors using a single laser. Although SMILE obtains similar results to femtosecond laser in situ keratomileusis (LASIK) with spherical myopia, it has deficiencies in astigmatism correction.

PURPOSE
The purpose of this study was to compare refractive outcomes and high-order aberrations (HOAs) between SMILE and femtosecond LASIK corneal procedures at 1 year post-operative.

METHODS
Ninety-two patients (181 eyes) with myopia/myopic astigmatism underwent either SMILE (group 1) or femtosecond LASIK (group 2). The refractive target was to achieve emmetropia in all cases. Data were analyzed to determine significance of change in refraction and HOAs. Furthermore, astigmatism was subjected to vector analysis using the Thibos (calculation of change, Δ, in J
0 and J
45 values) and Alpins (calculation of difference, ΔC, between target-induced astigmatism [TIA] and surgically induced astigmatism) methods.

RESULTS
Forty-five patients (89 eyes) from group 1 and 47 patients (92 eyes) from group 2 completed the study. The main significant (P ≤ .001) findings were as follows: (a) residual astigmatism was greater in group 1; (b) group 1, ΔJ
0 = 1.015J
0 + 0.040 (R = 0.861), ΔJ
45 = 1.082J
45 + 0.019 (R = 0.792), ΔC = 0.401TIA + 0.323 (R = 0.489), and mean spherical aberration increased from −0.003 (SD, ±0.059; 95% confidence interval [CI], −0.015 to 0.009) to 0.028 μm (SD, ±0.041; 95% CI, −0.037 to −0.020); and (c) group 2, ΔJ
0 = 0.952J
0 − 0.005 (R = 0.921), ΔJ
45 = 0.962J
45 − 0.002 (R = 0.923), ΔC = 0.187TIA + 0.101 (R = 0.272), mean coma reduced from 0.114 (SD, ±0.087; 95% CI, 0.096 to 0.132) to 0.077 μm (SD, ±0.059; 95% CI, 0.065 to 0.089), and trefoil from 0.089 (SD, ±0.049; 95% CI, 0.079 to 0.0990) to 0.056 μm (SD, ±0.047; 95% CI, 0.046 to 0.066).

CONCLUSIONS
In comparison with SMILE, femtosecond LASIK offered better precision in the overall control of astigmatism and HOAs.
The Area under the Main Sequence as an Alternative Method to Measure Saccadic Dynamics
Authors: Busettini Claudio , Braswell Christy Jennifer 
Published: October 2018

SIGNIFICANCE
This study shows that the area under the main sequence (MSAREA) is a valid alternative to the standard peak-velocity main sequence in measuring saccadic dynamics. A one-parameter area model, MSAREA = G
PW = 1.55 × SACSIZE1.55, with SACSIZE as the size of the saccade, 1.55 as a power factor, and G
PW = 1.55 as a gain parameter, is presented.

PURPOSE
SACPEAK = V
max × (1 − e
−SACSIZE/SAT) is the traditional model used to describe the saccadic main sequence, the relationship between the size of the movement and its peak velocity (SACPEAK). In the previous article, we have shown that there is a strong linear correlation between the two parameters V
max and SAT, which severely affects the model's clinical applicability. The purpose of this study is to see if, by using the MSAREA as an alternative approach, we can overcome the limitations of the traditional model.

METHODS
Participants and main sequence data are the same as the previous study. A trapezoidal integration was used to estimate the MSAREAs as a function of SACSIZE.

RESULTS
A two-parameter area model was computed to determine the range of variability of its parameters and R
2 values. These were then used as reference values in the search for one-parameter alternatives. The one-parameter model MSAREA = G
PW = 1.55 × SACSIZE1.55 performed well for all data sets. We tested its validity by performing a comparison with other one-parameter area models.

CONCLUSIONS
Area models are superior to peak-velocity models in terms of R
2 and stability and can be reduced to robust one-parameter expressions with only limited degradation in R
2. This not only greatly simplifies the determination if a set is inside or outside a reference population but also allows for direct comparisons between sets, with the saccadic dynamics expressed by a simple linear gain factor (G
PW = 1.55).
Mantle Cell Lymphoma of the Lacrimal Gland
Authors: Ana-Magadia Marian Grace , Takahashi Yasuhiro , Valencia Ma. Regina Paula , Kakizaki Hirohiko 
Published: October 2018

Abstract
The authors present 2 female patients of mantle cell lymphoma (MCL) involving the lacrimal gland. The patients include a 75-year-old female and a 59-year-old female. Both patients presented with palpable upper eyelid masses. The first patient was previously diagnosed with gastric and ileocecal MCLs and underwent chemotherapy with remission. The second patient had distant lesions in the muscular limbs that were confirmed to be MCL after the diagnosis of lacrimal gland MCL. Both patients underwent chemotherapy with complete remission.
Preference and Perception of Enhanced Images During Endonasal Endoscopic Surgery
Authors: Mulazimoglu Selcuk , Anadolu Yucel , Beton Suha , Basak Hazan , Yorulmaz Irfan , Meco Cem 
Published: October 2018

Abstract
Image enhancement is used widely in endoscopic sinonasal surgery. It is yet to be established whether image enhancement has advantages over white-light endoscopy. The authors aimed to evaluate the preferences and subjective visual perception of image enhancement in diagnostic images acquired at the beginning of endonasal endoscopic surgeries. An online survey consisting of 12 endoscopic images, 4 enhanced with Clara mode, 4 enhanced with Chroma mode, and 4 enhanced with Clara+Chroma mode, was distributed. The enhanced images were randomly presented with nonenhanced white-light images. These images were captured at the beginning of endonasal endoscopic surgeries for septal perforation, septal deviation, and chronic rhinosinusitis. Survey respondents (n = 205) included 81 otorhinolaryngologists, 94 other specialty physicians (35 endoscopy/laparoscopy users and 59 nonusers), and 30 nonmedical image experts. They were asked to choose superior images according to brightness, contrast and sharpness, depth of field, and overall preference. A quantitative study was also conducted to evaluate different enhancement modes. The authors found that Clara enhanced brightness and Chroma enhanced contrast and sharpness significantly (P < 0.001). Overall, 91.8% chose Clara and 91.7% chose Clara+Chroma-enhanced images for brightness enhancement. For contrast and sharpness, 87% chose Clara+Chroma and 86.7% chose Chroma. There was no significant difference between perception scores among the groups. Our survey group showed a significantly high overall preference for enhanced images. This preference was independent of profession or experience, but closely related to the quantitative enhancement of the specific mode. Continuous use of image enhancement in endonasal surgery may have advantages over white-light endoscopy.
Genial Tubercle Fracture
Authors: Sasaki Ryo , Okamoto Toshihiro , Sangu Noriko , Watanabe Yorikatsu , Ando Tomohiro 
Published: October 2018

Abstract
Genial tubercle fracture is a rare mandibular fracture. It is classified into 2 different types based on the mechanism of injury, including type I, associated with an atrophied edentulous mandible or denture, and type II, associated with mandibular fracture. Although type I usually can be treated by only observation, type II may cause obstruction of the pharyngeal airway due to hematoma and edema of the floor of the mouth. In this report, genial tubercle fracture associated with mandibular fracture caused by a traffic accident was reported. Reconstructed 3-dimensional images of the pharyngeal airway indicated that there was almost no airway space around the intratracheal tube at the naso- and oropharynx.
Early Initiation of Continuous Renal Replacement Therapy Induces Fast Hypothermia and Improves Post-Cardiac Arrest Syndrome in a Porcine Model
Authors: Xu Jiefeng , Chen Qijiang , Jin Xiaohong , Wu Chunshuang , Li Zilong , Zhou Guangju , Xu Yongan , Qian Anyu , Li Yulin , Zhang Mao 
Published: October 2018

ABSTRACT
Rapid induction of hypothermia early after resuscitation can be an effective strategy against post-cardiac arrest syndrome (PCAS). Preliminary data suggested that continuous renal replacement therapy (CRRT) might be an efficient method to rapidly induce hypothermia. In this study, we investigated the efficacy of cooling induced by CRRT and its effects on the outcomes of PCAS in a porcine model.
Thirty-two male domestic pigs weighing 36 ± 2 kg were randomized into 4 groups: sham control (n = 5), normothermia (n = 9), surface cooling (SC, n = 9), and CRRT (n = 9). Sham animals underwent the surgical preparation only. The animal model was established by 8 min of untreated ventricular fibrillation and then 5 min of cardiopulmonary resuscitation. At 5 min after resuscitation, the animals were cooled by either the combination of an earlier 8-h CRRT and later 16-h SC or the whole 24-h SC in the 2 hypothermic groups. For the other 2 groups, a normal temperature of 38.0 ± 0.5°C was maintained throughout the experiment.
Blood temperature was decreased to 33°C within 28 min in animals treated with CRRT, which was significantly faster than that in the SC group requiring 185 min to achieve target temperature. Post-resuscitation myocardial dysfunction, brain injury, and systemic inflammation were significantly improved in the 2 hypothermic groups compared to the normothermia group. However, the improvement was significantly greater in the CRRT group than in the SC group.
In conclusion, fast hypothermia was successfully induced by CRRT and significantly alleviated the severity of PCAS in a porcine model.
Informative for Decision Making? The Spectrum and Consistency of Outcomes After Living Kidney Donation Reported in Trials and Observational Studies
Authors: Hanson Camilla S. , Sautenet Benedicte , Craig Jonathan C. , Chapman Jeremy R. , Knoll Greg , Reese Peter P. , Tong Allison 
Published: October 2018

Background
Evidence about outcomes after living kidney donation is needed both to inform donor acceptance criteria, and to guide the decisions of potential donors and their healthcare providers about donation. However, the scope and heterogeneity of outcomes reported in research and their relevance to decision making is uncertain. To determine the spectrum and consistency of outcomes reported in randomized trials and observational studies in living kidney donors 18 years or older.

Methods
Electronic databases were searched for randomized trials and observational studies reporting outcomes in adult living kidney donors published from January 2011 to May 2017. All outcome domains and measurements were extracted, and their frequency and characteristics were evaluated.

Results
Of the 268 eligible studies, 14 (5%) were randomized and 254 (95%) observational. Overall, 136 (51%) studies were short-term (≤1 year follow up) and reported 109 outcome domains, of which 51 (47%) were classified as clinical, 35 (32%) were surrogate, and 23 (21%) were donor-reported. The 5 most commonly reported domains were kidney function (154, 58%), time to discharge (96, 36%), blood loss (85, 32%), operative time (79, 30%) and blood pressure (74, 28%). Quality of life (13%), mortality (16%), end-stage kidney disease (10%) and cardiovascular events (9%) were reported infrequently.

Conclusions
The outcomes of living kidney donation reported in contemporary trials and observational studies are numerous, heterogeneous, and often focused on short-term surgical complications. Consistent reporting of outcomes relevant to decision making is needed to better inform and prepare donors for outcomes after donation.