bluuebunny/crossref_metadata_2025_split huggingface dataset:
A rare complication after ureterorenoscopy lithotripsy: Subcapsular renal hematoma
Authors: Lu Xiaofei , Chen Yingchao , Cao Weiliang , Ding Zhiyong , Zhou Benzheng 
Published: November 2024

Objective: To evaluate the prevalence, risk factors, clinical manifestations, and outcomes of subcapsular renal hematoma (SRH) following ureterolithotripsy. Patients and Methods: Between January 2014 and December 2023, patients who underwent ureterorenoscopy lithotripsy (URL) at our hospital were retrospectively reviewed. Clinical data including basic information, calculi-related indicators, and perioperative period data were collected. A Student’s t-test was used for continuous data, while a Chi-square test or Fisher’s exact test was utilized for categorical data. Results: A total of 2098 patients treated with URL for ureteric stones were included in this study. The incidence of SRH after URL was 0.52% (11 cases). All SRH cases were confirmed by non-contrast computed tomography, with an average patient age of 55.54 years (range 34–84). The mean stone size in patients with SRH was 10.54 cm (range 0.8–1.5). Patients with SRH had a higher proportion of severe hydronephrosis caused by ureteral stones (54.55% vs 26.07%, p = 0.032) and narrow ureters (45.45% vs 8.04%, p < 0.001) compared to those without SRH. Patients with SRH experienced a longer length of stay, with a significant difference between the two groups (11.64 ± 5.05 vs 3.87 ± 8.12, p < 0.001). Nine patients were managed conservatively without further intervention, while embolization was required in one patient and percutaneous drainage was performed in another. All SRH cases resolved completely during a 4-month follow-up. Conclusions: The incidence of SRH following URL is low, with severe hydronephrosis and narrow ureters identified as risk factors. Most SRH cases can be successfully managed conservatively, although patients with SRH may experience a significant prolongation of their length of stay.
Health seeking behaviour and diagnostic delays in SLE: A multi-ethnic Malaysian cohort study
Authors: Nordin Fatimah Zanirah , Shaharir Syahrul Sazliyana , Mohamed Said Mohd Shahrir , Mohd Rozita , Sakthiswary Rajalingham , Tengku Mohd Tengku Amatullah Madeehah , Jaafar Mohd Hafiz , Yew Wong Chin 
Published: November 2024

Introduction Heterogeneity of the clinical manifestations of systemic lupus erythematosus (SLE) may lead to diagnostic delays. This study is aimed at determining the health-seeking behaviour patterns and factors associated with diagnostic delays in a multi-ethnic SLE cohort in Malaysia. Methodology This was a cross-sectional study involving SLE patients who visited our institute between January 2020 and June 2021. A review of the medical records and face-to-face interviews were conducted to obtain sociodemographics, SLE disease characteristics and the intervals from the first symptoms to the diagnosis. Health-seeking behaviours were assessed by asking about the patients’ first action during the initial symptoms and were divided into: (i) seeking professional health personnel; (ii) self-treatment; and (iii) the use of the internet as a primary source of information. Diagnostic delays were defined as the interval between initial symptoms and SLE diagnosis of more than 6 months. Low-level disease activity state (LLDAS) at 12 months was assessed from the medical records. Univariate and multivariate logistic regression analysis was subsequently conducted to determine factors associated with diagnostic delays. Results Among the 154 patients included in the study, 24% ( n = 37) had delayed diagnosis. The delay was significantly higher among the Indian versus Malay versus Chinese (42.9% vs 28% vs 10.8%, p = 0.037). Patients with rash tend to have delayed diagnosis (37.8% vs 22.2%, p = 0.08) while fewer patients with frothy urine had delayed diagnosis (8.1% vs 21.4%, p = 0.09). No significant association was found between health-seeking behaviours and diagnostic delays. The rate of LLDAS at 12 months was significantly lower among patients with delayed diagnosis (43.2% vs 70.0%, p = 0.006). Chinese ethnicity remained the only significant factor associated with lesser diagnostic delays in the multivariate analysis, with OR 0.30 (CI 0.09–0.93), p = 0.037. Conclusion There were ethnic disparities in the early diagnosis of SLE in Malaysia, with Indian patients having a longer interval between the first symptom and diagnosis while the Chinese were associated with lower diagnostic delays. Early diagnosis predicted early attainment of LLDAS, suggesting that prompt recognition of the initial SLE symptoms is important.
Cultivating Esportspersonship: How Scholastic Esports Coaches Perceive Facilitating Positive Youth Development
Authors: Farber Matthew , Merchant William 
Published: November 2024

Background Coaches may promote positive youth development (PYD) through youth sports programs, which can lead to outcomes, such as life skills and well-being. Scholastic esports programs, much like traditional school sports teams and clubs, have adult coaches who play a role in the development and success of teams. Purpose This study aims to explore the gap in research on scholastic esports coaches’ perspectives on their cultivation of PYD. Method This large-scale pilot study used a sequential explanatory mixed methods design. Quantitative rating responses to a coaching survey were collected and analyzed using an exploratory data analysis. Trends of interest were used to create interview questions that then informed and added context to the themes identified in the quantitative phase. Results Survey results revealed common trends in responses that highlighted the development of life skills, fostering a socially positive environment, and a genuine affinity for both coaching esports and working with young people. Interviews emphasized that coaches saw esports programs as a place for students to learn new skills, increase confidence, and benefit from being part of a social community. Discussion and Conclusion Findings suggest that scholastic esports programs afford PYD opportunities through coaches’ motivations, philosophies, and impacts. Coaches create conditions where youth can learn sportspersonship.
Perceived social support and symptoms of depression and anxiety in emerging adulthood: A Swedish prospective cohort study
Authors: Låftman Sara Brolin , Lundin Andreas , Östberg Viveca 
Published: November 2024

Aims: The transition from adolescence to young adulthood, often referred to as ‘emerging adulthood’, is a challenging period in life, and mental health problems are common. Although a large number of studies have shown that social support is linked with fewer mental health problems, few longitudinal studies have examined these associations during this life phase. The aim of the current study was to examine the associations between perceived social support from different sources – family, friends and significant other – at age 17–18 and symptoms of depression and anxiety at age 20–21. Methods: Data were obtained from the cohort study Futura01 based on a Swedish national sample of adolescents attending grade 9 in 2016/2017. We used survey information from 2019 (age 17–18) and 2022 (age 20–21) and linked registry information ( N=2722). Symptoms of depression and anxiety were measured by the Patient Health Questionnaire-4 (PHQ-4) at age 20–21. Perceived social support was measured by the Multidimensional Scale of Perceived Social Support (MSPSS) at age 17–18. Control variables included sociodemographic characteristics and indicators of mental health problems at age 17–18. Binary logistic regressions were performed. Results: When mutually adjusting for all sources of perceived social support, family support at age 17–18 had inverse associations with symptoms of both depression and anxiety at age 20–21. Perceived support from friends was associated with subsequent symptoms of anxiety only. Conclusions: Perceived social support can be a protective factor against mental health problems in emerging adulthood. The family serves a particularly important source of social support.
Effects of physical activity on menopausal symptoms, psychosomatic factors and well-being among working women in England: A path analysis
Authors: Asiamah Nestor , Aladenola Olajumoke B , Cronin Camille , Sepp Leeni , O’Callaghan Kirsty 
Published: November 2024

Background: Research to date suggests that physical activity (PA) can buffer menopausal symptoms and support well-being, but there is limited evidence on the link between PA and menopausal symptoms in the United Kingdom, and no study has assessed how PA affects well-being through menopausal symptoms and three psychosomatic factors (i.e. depression, anxiety and stress). Objectives: This study investigated whether PA affects well-being through menopausal symptoms and psychosomatic factors. This study focuses on how PA influences working women with menopause. Design: A cross-sectional design based on the STROBE (i.e. Strengthening the Reporting of Observational Studies in Epidemiology) checklist was adopted. Methods: The participants were 324 working women in England. An online self-reported questionnaire was utilised to gather data through Qualtrics. The data were analysed with path analysis through structural equation modelling, and sensitivity analyses were performed to avoid or reduce statistical bias. Results: PA had a negative effect on menopausal symptoms (β = −0.21; p < 0.001) but a positive effect on well-being (β = 0.19; p < 0.001). Menopausal symptoms had a negative indirect effect on well-being, but PA had a positive indirect effect on well-being through menopausal symptoms and the three psychosomatic factors. Conclusion: PA was positively associated with well-being but negatively associated with menopausal symptoms. Menopausal symptoms may lower well-being through anxiety, depression and stress, but PA can be associated with better well-being through depression, anxiety and stress.
Evaluating the Importance of Return to Sports and Hamstring Strength in a Discrete Choice Experiment for Anterior Cruciate Ligament Injury
Authors: Feeley Scott M. , Broome Jalen N. , Cherelstein Rachel E. , Neubauer Benjamin E. , Kuenze Christopher M. , Chang Edward S. 
Published: November 2024

Background: With emerging treatments for anterior cruciate ligament (ACL) injury, analysis of patient preferences is lacking to align clinical care and research with patient priorities. Purposes: To identify patient priorities for outcomes after surgical intervention if they were to sustain an ACL tear, analyze what outcome measures influenced preferences, and determine whether patient demographics influenced preferences. Study Design: Cross-sectional study. Methods: The authors screened patients aged 18 to 30 years who presented for upper extremity complaints to a single institution in 2023. Patients were excluded for current lower extremity injury or history of a knee injury requiring surgical consultation. The authors designed a discrete choice experiment through literature review of outcome measures for bridge-enhanced ACL restoration (BEAR) and ACL reconstruction (ACLR) with hamstring tendon autograft. Measures included return to sports, risk of arthritis, risk of reinjury, and hamstring strength. Patients chose surgery A (ACLR with hamstring tendon autograft) or surgery B (BEAR) and then rated the importance of each outcome measure on their selection. Results: In total, 100 participants (36 female; mean age, 25.1 ± 4.0 years) completed the discrete choice experiment. Overall, 56.0% participated in sports and 80.0% were employed. Based on surgery choice group, there were no significant differences in sex, age, Marx Activity Scale score, sports participation, or employment status between patients who selected BEAR or ACLR with hamstring tendon autograft (all P > .361). Return to sports and hamstring strength were significant priorities for patients in procedure selection ( P ≤ .011). Of the patients who selected ACLR with hamstring tendon autograft, 31.6% would not elect to undergo this procedure. Conclusion: In this discrete choice experiment of adults without prior ACL injury, return to sports and hamstring strength were identified as patient priorities when selecting a procedure for ACL injury. Risk of reinjury, however, was not a significant factor in procedure selection. Importantly, these priorities were maintained regardless of patient characteristics, activity level, or employment status.
ASIA syndrome and the nociceptive storm: A case report of a refractory headache and a pathophysiological hypothesis
Authors: Makita Luana Miyahira , Grossklags Locatelli Giovanna , Josetti Giovanna Porreca , Itimura Giovana Takeshita , Piovesan Elcio Juliato 
Published: November 2024

Background Autoimmune/inflammatory syndrome induced by adjuvants (ASIA) encompasses a set of immune rare diseases triggered by adjuvants, like silicone. Although headache is typical in these cases, the literature lacks information about its characteristics and pathophysiology in ASIA. Objective Describe and discuss a case of ASIA with headache as the main symptom, approaching its immunopathological and clinical aspects. Case A 45-year-old woman with silicone prosthesis presented an intense headache, accompanied by chronic fatigue, sleep and skin disturbances, paresthesia, and generalized body aches. She had sought medical care over the past 2 years, with no underlying identified until then. The fulfillment of ASIA diagnostic criteria and subsequent prosthesis explantation resulted in symptom resolution. Conclusion Additional research is required to understand the semiotic patterns linked to ASIA syndrome-induced headaches. A dysregulation in histaminergic GPCR and GRK levels is hypothesized by the authors to be involved in the main mechanisms responsible for leading the headache nociceptive storm induced in ASIA.
A network of pro-inflammatory genes repressed by clock signaling in bronchial epithelium
Authors: Li Xiaopeng , Srikanthan Karthi , Rahmawati Siti Farah , Slebos Dirk-Jan , Shah Pallav L , Johnson Philip J , Kistemaker Loes E.M. , Nagelkerke Anika , Gosens Reinoud 
Published: November 2024

BackgroundCircadian rhythms are biological cycles that regulate various physiological processes, including immune responses, tissue repair, and oxidative stress. Previous studies indicated a role for distorted circadian signaling in Chronic obstructive pulmonary disease (COPD).MethodsIn this study, we performed an unbiased analysis of the gene network that co-expresses with circadian clock signaling in COPD using Weighted Gene Co-expression Network Analysis on RNA sequencing data from bronchial brushes of COPD patients.ResultsWe found that a large network of pro-inflammatory genes includingCXCL8,IL1B,IL1A,CSF1andTGFB1, was inversely correlated with the expression of core clock genes in bronchial brushes of COPD patients. In contrast, genes that positively co-expressed with circadian clock signaling associated with ciliated cell differentiation. Furthermore, we found that both circadian clock genes and their co-expressed genes were differentially expressed in lung tissues of COPD patients compared to healthy smokers.ConclusionsOur results provide an unbiased and comprehensive analysis of the gene expression network co-expressed with circadian clock signaling in bronchial epithelium. Our findings suggest an association between circadian clock signaling and enhanced inflammatory gene expression in COPD patients.
Targeted proteomics in extracellular vesicles identifies biomarkers predictive for therapeutic response in sarcoidosis
Authors: Kraaijvanger Raisa , Janssen Bonás Montse , Paspali Ioanna , Grutters Jan C. , Veltkamp Marcel , de Kleijn Dominique P.V. , van Moorsel Coline H.M. 
Published: November 2024

BackgroundApproximately 30% of patients with sarcoidosis, a systemic granulomatous disease of unknown cause, need treatment to alleviate symptoms or prevent organ damage. Prednisone and methotrexate (MTX) are the most commonly used drugs, however, success of treatment varies from patient to patient. In this study, we search for biomarkers and pathways that predict response to treatment with prednisone or MTX in extracellular vesicles (EVs).MethodsA targeted proteomics approach (OLINK Bioscience) was used in which 92 proteins were measured in two base-line EV fractions in 32 patients treated for pulmonary sarcoidosis (8 responders and 8 non-responders each for prednisone and MTX). Top three proteins were replicated in 62 prednisone and 76 MTX treated patients.ResultsWe identified 11 differentially expressed proteins (DEPs) between responders and non-responders to prednisone treatment, and 16 DEPs for patients treated with MTX. Reactome pathway analysis showed DEPs in prednisone to be involved in NF-kB and interleukin signalling pathways. The DEPs in MTX were involved in transduction of GPI-anchored proteins and MAPK signalling pathway. CHI3L1 for prednisone and CPA1 for MTX were replicated as significant predictors of response.ConclusionThis study is the first to shows that in pulmonary sarcoidosis the response to treatment with prednisone or MTX can be predicted at base-line by different EV proteins active in different pathways. Using these markers and associated pathways to identify patients with a high probability of response to therapy will aid personalized treatment choice and improve treatment outcome.
The efficacy and safety of alcohol septal ablation stratified by alcohol dosage for patients with hypertrophic obstructive cardiomyopathy: a systematic review and meta-analysis
Authors: Elshahat Ahmed , Ellabban Mohamed , Amin Ahmed Mostafa , Diaa Ahmed , Bakr Ali , Rzk Fayed , Mansour Anas , Bedak Omar , Eid Mahmoud , Elaraby Ahmed , Elkasaby Mohamed Hamouda , Abdelaziz Ahmed 
Published: November 2024

Abstract
Background
Alcohol septal ablation (ASA) is recommended for moderate to severe symptomatic patients with hypertrophic obstructive cardiomyopathy. The current guidelines don not recommend particular alcohol doses and the amount of alcohol injected into the septal artery is based more on the interventionalist’s decision rather than on systematic evidence. Our objective is to execute a comprehensive assessment of the efficacy and safety of low alcohol doses (1–2 ml)) in comparison to large ones (2–4 ml).

Methods
Multiple databases, encompassing PubMed, WOS, Scopus, Embase, and Cochrane library were systemically assessed from inception to October 2023. Randomized controlled trials (RCTs) and observational studies comparing low-alcohol and high-alcohol dose in patients with HOCM was included. The main outcome was creatine kinase-MB (CK-MB). The secondary ones are septal thickness, left ventricular outflow pressure gradient, and atrioventricular (AV) block.

Results
Eight studies, with a total of 1446 individuals, were finally involved in our investigation. low alcohol doses showed lower CK-MB levels relative to high ones (MD=-0.93, 95% CI [-1.15 to -0.72], P = 0.00001). Furthermore, in terms of septal thickness, left ventricular outflow pressure gradient, and AV block, neither of the two doses was preferred.

Conclusion
We propose that the low alcohol dose is equally effective as the high dose. moreover, the low alcohol dose was associated with a lower CK-MB levels in comparison to the high one.

PROSPERO registration
CRD42024511537
German language adaptation of the Cluster Headache Quality of Life Scale (CH-QoL)
Authors: Kuhn Hannah , Petzke Tara , Schreiber Marie-Christin , Gaul Charly , Witthöft Michael , Klan Timo 
Published: November 2024

Abstract
Background
Cluster headache (CH) can lead to high disability and reduced quality of life (QoL). QoL should be assessed as an important outcome both in research and in clinical care. The 28-item Cluster Headache Quality of Life Scale (CH-QoL) is a valid self-report questionnaire to assess disease-specific QoL. A German version is lacking. This study aims to develop a German-language version and to determine its psychometric properties.

Methods
The CH-QoL was translated into German by two headache experts and blindly back-translated by two professional translators. Additionally, the CH-QoL was tested for comprehensibility by nine persons with CH. In this multi-stage process, linguistic discrepancies were repeatedly discussed in an expert panel and appropriate modifications were conducted to optimize the translation. A cross-sectional online survey, comprising the CH-QoL and further self-report questionnaires such as the Cluster Headache Scales (CHS), yielded a sample of N = 106 persons with CH (53.8% female, M = 45.5 [SD = 11.8] years, 48.1% episodic CH, 51.9% chronic CH, 79.2% currently having recurring CH attacks).

Results
Exploratory factor analysis revealed two clearly interpretable factors (“restriction of activities of daily living”, and “impact on mood and interpersonal relationships”), which is in discrepancy to the four factors of the original English version. The model fit was good, with χ2(323) = 590.74, p < .001, RMSEA = 0.088, SRMR = 0.053, TLI = 0.857. Reliability was very good (McDonald’s omega ω = 0.97, Subscale/Factor 1: ω = 0.96, Subscale/Factor 2: ω = 0.92). Correlational analyses (correlations with related questionnaires as well as with clinical parameters) confirmed convergent validity.

Conclusions
Since the German version of the CH-QoL has very good psychometric properties, it is suitable for the assessment of disease-specific QoL in people with CH in German-speaking countries.

Trial registration
This study is registered with the German Clinical Trials Register (DRKS-ID: DRKS00028475, registration date 03 March 2022).