bluuebunny/crossref_metadata_2025_split huggingface dataset:
Correlation of Cervical Cancer Mortality with Fertility, Access to Health Care and Socioeconomic Indicators
Authors: Vale Diama Bhadra , Sauvaget Catherine , Murillo Raul , Muwonge Richard , Zeferino Luiz Carlos , Sankaranarayanan Rengaswamy 
Published: March 2019

Objective The present study aimed to examine which development indicators are correlated with cervical cancer (CC) mortality rates in Brazil.
Methods This was an ecological study that correlated mortality rates and indicators, such as human development index (HDI), gross domestic product (GDP) per capita, illiteracy rate, fertility rate, screening coverage, proportion of private health insurance use, density of physicians, and density of radiotherapy centers. The mortality rates were obtained from the Brazilian national registry, while the indicators were based on official reports from the Ministry of Health. Univariate and multivariate linear regression was used.
Results Among the states of Brazil, the average age-specific CC mortality rate from 2008 to 2012 varied from 4.6 to 22.9 per 100,000 women/year. In the univariate analysis, HDI, proportion of private health insurance use, density of physicians, and density of radiotherapy centers were inversely correlated with the mortality rates. Fertility rate was positively correlated with the mortality rates. In the multivariate analysis, only fertility rate was significantly associated with the CC mortality rate (coefficient of correlation: 9.38; 95% confidence interval [CI]: 5.16–13.59).
Conclusion A decrease in the fertility rate, as expected when the level of development of the regions increases, is related to a decrease in the mortality rate of CC. The results of the present study can help to better monitor the quality assessment of CC programs both among and within countries.
Novel HIVEP2 Variant p.Q1248* is Associated with Developmental Delay: A Case Report
Authors: Jain Angita , Atwal Paldeep S. 
Published: March 2019

AbstractIn this report, we describe a 5-year-old boy with global developmental delay who presented for medical genetic evaluation. We performed whole exome sequencing that revealed the involvement of a heterogenous variant p.Gln1248Ter (CAG > TAG): c.3742 C > T inherited de novo in exon 5 of HIVEP2 (human immunodeficiency virus type I enhancer binding protein 2; NM_006734.3). The gene variant p.Q1248* is interpreted to be associated as a cause of the intellectual disability. We review pathomechanisms of HIVEP2 and discuss the reasoning behind the pathogenicity of this novel variant. To the best of our knowledge, this the first reported case that demonstrates the p.Q1248* variant as pathogenic.
Preoperative Evaluation of the Effects of Sigmoid Sinus Ligation with both Endovascular and Open-Field Occlusion Tests before Removal of Petroclival Tumors
Authors: Shitara Satoshi , Inoue Takuro , Tanaka Toshiki , Hirai Hisao , Fukushima Takanori 
Published: March 2019

Abstract
Background Surgery for petroclival tumors is very challenging for neurosurgeons because the position of the tumor in relation to the brainstem, cranial nerves, and posterior fossa vessels greatly restricts the surgical field. Some papers have described using sigmoid sinus ligation to open the surgical field; however, pre- and intraoperative evaluations of the safety of ligation have been limited, despite the risk of complications from venous insufficiency. Here, we describe our method of preoperatively evaluating the potential safety of a retrolabyrinthine transsigmoid approach with nondominant ipsilateral sigmoid sinus ligation (RLTSwSSL).
Methods A retrospective review was conducted on petroclival tumors treated over a 5-year period with RLTSwSSL after evaluation with both an endovascular balloon occlusion test (BOT) and an open-field sinus clipping occlusion test (COT). Changes in pressure of < 10 mm Hg and the absence of neurodegeneration during the tests indicated that it would be safe to proceed with permanent ligation.
Results Four patients with large petroclival tumors underwent surgery via RLTSwSSL after detailed preoperative evaluations with both BOT and COT. All patients had uneventful courses of recovery without developing any complications derived from venous insufficiency.
Conclusion In our case series, we have described a protocol for using both BOT and COT to evaluate the likely outcomes after sigmoid sinus ligation and thereby to improve safety. Further studies are needed to establish definite criteria for both occlusion tests that will ensure good outcomes.
The mucin-selective protease StcE enables molecular and functional analysis of human cancer-associated mucins
Authors: Malaker Stacy A. , Pedram Kayvon , Ferracane Michael J. , Bensing Barbara A. , Krishnan Venkatesh , Pett Christian , Yu Jin , Woods Elliot C. , Kramer Jessica R. , Westerlind Ulrika , Dorigo Oliver , Bertozzi Carolyn R. 
Published: March 2019

Significance
Mucin-domain glycoproteins are found in nearly every tissue of the human body, and are important in biological processes ranging from embryogenesis to cancer. Because there are few tools to study mucin domains, their biological functions at the molecular scale remain unclear. Here, we help address a hurdle to the study of mucin-domain glycoproteins by characterizing a bacterial protease with selectivity for mucins. This mucinase selectively removes native mucins from cell surfaces and cuts them into fragments amenable to analysis.
Dual actions of group BStreptococcuscapsular sialic acid provide resistance to platelet-mediated antimicrobial killing
Authors: Uchiyama Satoshi , Sun Josh , Fukahori Kyoko , Ando Nao , Wu Mengyou , Schwarz Flavio , Siddiqui Shoib S. , Varki Ajit , Marth Jamey D. , Nizet Victor 
Published: March 2019

SignificancePlatelets have an important role in blood clotting, but also function in immune responses, including the release of antimicrobial peptides that eliminate pathogens such asStaphylococcus aureus. Here we observe that group BStreptococcus(GBS), a leading cause of sepsis and meningitis in human newborns, is not killed by platelets. The key to GBS platelet resistance is a polysaccharide capsule that coats the bacterial surface and contains sialic acid (Sia), a common sugar present on all human cells. GBS Sia blocks platelet-derived antimicrobial factors, and also engages an inhibitory receptor (Siglec-9) on the platelet surface to block platelet activation. Platelet resistance is a novel consequence of GBS “molecular mimicry” of its host and contributes to its propensity to produce bloodstream infection.
Using massive online choice experiments to measure changes in well-being
Authors: Brynjolfsson Erik , Collis Avinash , Eggers Felix 
Published: March 2019

Significance
Gross domestic product (GDP) measures production and is not meant to measure well-being. While many people nonetheless use GDP as a proxy for well-being, consumer surplus is a better measure of consumer well-being. This is increasingly true in the digital economy where many digital goods have zero price and as a result the welfare gains from these goods are not reflected in GDP or productivity statistics. We propose a way of directly measuring consumer well-being using massive online choice experiments. We find that digital goods generate a large amount of consumer welfare that is currently not captured in GDP. For example, the median Facebook user needed a compensation of around $48 to give it up for a month.
Macroevolutionary diversification rates show time dependency
Authors: Henao Diaz L. Francisco , Harmon Luke J. , Sugawara Mauro T. C. , Miller Eliot T. , Pennell Matthew W. 
Published: March 2019

SignificanceSome branches of the tree of life are incredibly diverse, while others are represented by only a few living species. Ultimately, this difference reflects the balance of the formation and the extinction of species. Countless explanations have been proposed for why the rates of these two processes vary between lineages, including aspects of the organisms themselves and the environments they live in. Here we reveal that a substantial amount of variation in these rates is associated with a simple factor: time. Younger groups appear to accumulate diversity at much faster rates than older groups. This time scaling of macroevolutionary rates suggests that there may be hidden generalities governing the diversification of life on Earth.
DNA nanostructures coordinate gene silencing in mature plants
Authors: Zhang Huan , Demirer Gozde S. , Zhang Honglu , Ye Tianzheng , Goh Natalie S. , Aditham Abhishek J. , Cunningham Francis J. , Fan Chunhai , Landry Markita P. 
Published: March 2019

Significance
Plant bioengineering will be necessary to sustain plant biology and agriculture, where the delivery of biomolecules such as DNA, RNA, or proteins to plant cells is at the crux of plant biotechnology. Here, we show that DNA nanostructures can internalize into plant cells and deliver siRNA to mature plant tissues without external aid. Furthermore, we demonstrate that nanostructure size, shape, compactness, and stiffness affect both nanostructure internalization into plant cells and subsequent gene silencing efficiency. Interestingly, we also find that the siRNA attachment locus affects the endogenous plant gene silencing pathway. Our work demonstrates programmable delivery of biomolecules to plants and details the figures of merit for future implementation of DNA nanostructures in agriculture.
Airborne host–plant manipulation by whiteflies via an inducible blend of plant volatiles
Authors: Zhang Peng-Jun , Wei Jia-Ning , Zhao Chan , Zhang Ya-Fen , Li Chuan-You , Liu Shu-Sheng , Dicke Marcel , Yu Xiao-Ping , Turlings Ted C. J. 
Published: March 2019

Significance
Plants respond to herbivory and pathogenic infection with the synthesis of various defense compounds, including volatile compounds that are emitted into the environment. These volatiles can be perceived by neighboring plants and “prime” them for an attack by the specific attacker. We found that whitefly-infested tomato plants release volatiles that prime a defense against pathogens in neighboring plants, which goes at the cost of defenses against insect herbivores, making the neighboring plants more suitable for whitefly development. This apparent ability of whiteflies to manipulate plant defense responses through induced volatile emissions could explain the rapid spread of this invasive pest, and a good understanding of the mechanisms that are involved may lead to novel pest control strategies.
Feed-forward information and zero-lag synchronization in the sensory thalamocortical circuit are modulated during stimulus perception
Authors: Tauste Campo Adrià , Vázquez Yuriria , Álvarez Manuel , Zainos Antonio , Rossi-Pool Román , Deco Gustavo , Romo Ranulfo 
Published: March 2019

Significance
The direction of information flow between brain circuits may be key in cognitive functions. We addressed this problem by evaluating a directional correlation measure between simultaneously recorded neurons from somatosensory thalamus (ventral posterolateral nucleus, VPL) and somatosensory cortex (S1) sharing the same cutaneous receptive field while monkeys judged presence or absence of tactile stimuli. During stimulus presence, feed-forward (VPL → S1) information increased as a function of stimulus amplitude, while feed-back (S1 → VPL) information was unaffected. Simultaneously, zero-lag interaction emerged with increasing stimulus amplitude, contributing to thalamocortical synchronization. Furthermore, VPL → S1 information decreased during error trials. Also, both VPL → S1 and zero-lag interactions decreased when monkeys were not required to report stimulus presence. Thus, directional and coordinated information in the thalamocortical circuit is associated with stimulus perception.
Effects of fossil fuel and total anthropogenic emission removal on public health and climate
Authors: Lelieveld J. , Klingmüller K. , Pozzer A. , Burnett R. T. , Haines A. , Ramanathan V. 
Published: March 2019

Significance
We assessed the effects of air pollution and greenhouse gases on public health, climate, and the hydrologic cycle. We combined a global atmospheric chemistry–climate model with air pollution exposure functions, based on an unmatched large number of cohort studies in many countries. We find that fossil-fuel-related emissions account for about 65% of the excess mortality rate attributable to air pollution, and 70% of the climate cooling by anthropogenic aerosols. We conclude that to save millions of lives and restore aerosol-perturbed rainfall patterns, while limiting global warming to 2 °C, a rapid phaseout of fossil-fuel-related emissions and major reductions of other anthropogenic sources are needed.
Histone H2AX promotes neuronal health by controlling mitochondrial homeostasis
Authors: Weyemi Urbain , Paul Bindu D. , Bhattacharya Deeya , Malla Adarsha P. , Boufraqech Myriem , Harraz Maged M. , Bonner William M. , Snyder Solomon H. 
Published: March 2019

Significance
Histone H2AX elicits proper DNA repair through its phosphorylation by ataxia-telangiectasia mutated (ATM) kinase. While ATM senses reactive oxygen species, the role of H2AX in the maintenance of redox homeostasis remains unknown. Here we establish that H2AX deletion leads to impairment of mitochondrial function and repression of the mitochondrial biogenesis gene PGC-1α. Restoring PGC-1α abrogates mitochondrial deficits and mitigates cell death. This study unveils a role for H2AX in mitochondrial homeostasis associated with neuroprotection.
A specific amino acid motif ofHLA-DRB1mediates risk and interacts with smoking history in Parkinson’s disease
Authors: Hollenbach Jill A. , Norman Paul J. , Creary Lisa E. , Damotte Vincent , Montero-Martin Gonzalo , Caillier Stacy , Anderson Kirsten M. , Misra Maneesh K. , Nemat-Gorgani Neda , Osoegawa Kazutoyo , Santaniello Adam , Renschen Adam , Marin Wesley M. , Dandekar Ravi , Parham Peter , Tanner Caroline M. , Hauser Stephen L. , Fernandez-Viña Marcelo , Oksenberg Jorge R. 
Published: March 2019

SignificanceParkinson’s disease (PD) is a chronic, progressive neurodegenerative disease with both familial and sporadic forms and a clear genetic component. In addition, underlying immunoregulatory dysfunction and inflammatory processes have been implicated in PD pathogenesis. In this study, deep sequencing ofHLAgenes, which encode highly variable cell surface immune receptors, reveals specific variants conferring either risk or protection in PD. Because a history of cigarette smoking is known to be protective in PD, we analyzed the interaction of these genetic variants with smoking history in PD patients and healthy controls and found that the genetic effects are modified by history of cigarette smoking. These results provide a molecular model that explains the unique epidemiology of smoking in PD.
Growth hormone acts on liver to stimulate autophagy, support glucose production, and preserve blood glucose in chronically starved mice
Authors: Fang Fei , Shi Xuanming , Brown Michael S. , Goldstein Joseph L. , Liang Guosheng 
Published: March 2019

Significance
Nine million people starve to death annually. To understand starvation, we created a mouse model in which the mice receive a daily meal that contains 40% of normal calories. They consume each meal within 1 hour and fast for 23 hours. Normal mice maintain viable levels of blood glucose by increasing hepatic glucose production. Gluconeogenesis requires elevated plasma growth hormone (GH) and is accompanied by hepatic autophagy. GH-deficient mice become hypoglycemic, owing to decreased autophagy and glucose production. Here we show that mice lacking the liver GH receptor have reduced autophagy and become hypoglycemic. These data demonstrate that GH acts through its receptor in the liver to induce autophagy and enhance glucose production, maintaining blood glucose during famine.
Recursive embedding of viewpoints, irregularity, and the role for a flexible framework
Authors: van Duijn Max , Verhagen Arie 
Published: March 2019

AbstractThis paper discusses several conventional perspective operators at the lexical, grammatical, and narrative levels. When combined with each other and with particular contexts, these operators can amount to unexpected viewpoints arrangements. Traditional conceptualisations in terms of viewpoint embedding and the regular shifting from one viewpoint to the other are argued to be insufficient for describing these arrangements in all their nuances and details.We present an analysis of three cases in which viewpoints of speaker, addressee, and third parties are mutually coordinated: (i) global and local perspective structure in Nabokov’s novelLolita, (ii) postposed reporting constructions in Dutch, and (iii) the Russian apprehensive construction, which has a seemingly redundant negation marker in the subordinate clause. For each of these three cases, we discuss how traditional conceptualisations fall short. We discuss an alternative model of viewpoint construction which allows for the conceptual juxtaposition and mixing of different and simultaneously activated viewpoints.
On the effective action in presence of local non-linear constraints
Authors: Rançon Adam , Balog Ivan 
Published: March 2019

Abstract
The conditions for the existence of the effective action in statistical field theory, the Legendre transform of the cumulant generating function, in presence of non-linear local constraints are discussed. This problem is of importance for non-perturbative approaches, such as the functional renormalization group. We show that the Legendre transform exists as long as the non-linear constraints do not imply linear constraints on the microscopic fields. We discuss how to handle the case of effectively linear constraints and we naturally obtain that the second derivative of the effective action is the Moore–Penrose pseudo-inverse of the correlation function. We illustrate our discussion with toy-models, and show that the correct counting of degrees of freedom in non-linearly constrained statistical field theories can be rather counter-intuitive.
The Role of Weather on Schooling and Work of Young Adults in Madagascar
Authors: Marchetta Francesca , Sahn David E , Tiberti Luca 
Published: March 2019

AbstractWe examine the impact of rainfall variability and cyclones on schooling and work among a cohort of teens and young adults in Madagascar. We estimate a bivariate probit model using a panel survey conducted in 2004 and 2011 in this poor island nation, which is frequently affected by extreme weather events. Our results show that negative rainfall deviations and cyclones reduce the probability of attending school and encourage young men and, to a greater extent, women to enter the work force, and they reduce their French and math test scores. Less wealthy households are most likely to experience this school‐to‐work transition in the face of rainfall shocks. The finding is consistent with poorer households having less savings and more limited access to credit and insurance, which reduces their ability to cope with rainfall shortages. We also find that there are both contemporaneous and lagged effects of the weather shocks, and that they are of a similar magnitude. Our findings are robust to the use of a linear probability model, as well as a wide range of definitions of rainfall variations.
Simultaneous clustering of multiview biomedical data using manifold optimization
Authors: Yu Yun , Zhang Lei-Hong , Zhang Shuqin 
Published: March 2019

Abstract

Motivation
Multiview clustering has attracted much attention in recent years. Several models and algorithms have been proposed for finding the clusters. However, these methods are developed either to find the consistent/common clusters across different views, or to identify the differential clusters among different views. In reality, both consistent and differential clusters may exist in multiview datasets. Thus, development of simultaneous clustering methods such that both the consistent and the differential clusters can be identified is of great importance.

Results
In this paper, we proposed one method for simultaneous clustering of multiview data based on manifold optimization. The binary optimization model for finding the clusters is relaxed to a real value optimization problem on the Stiefel manifold, which is solved by the line-search algorithm on manifold. We applied the proposed method to both simulation data and four real datasets from TCGA. Both studies show that when the underlying clusters are consistent, our method performs competitive to the state-of-the-art algorithms. When there are differential clusters, our method performs much better. In the real data study, we performed experiments on cancer stratification and differential cluster (module) identification across multiple cancer subtypes. For the patients of different subtypes, both consistent clusters and differential clusters are identified at the same time. The proposed method identifies more clusters that are enriched by gene ontology and KEGG pathways. The differential clusters could be used to explain the different mechanisms for the cancer development in the patients of different subtypes.

Availability and implementation
Codes can be downloaded from: http://homepage.fudan.edu.cn/sqzhang/files/2018/12/MVCMOcode.zip.

Supplementary information
Supplementary data are available at Bioinformatics online.
Seeing More, Better Sight: Using an Interprofessional Model of Supervision to Support Reflective Child Protection Practice Within the Health Setting
Authors: Kelly Selina , Green Tracee 
Published: March 2019

AbstractDespite an extensive history in developing, delivering and leading child protection (CP) services, social workers are not an explicit part of the health-based response to CP in the UK. In this setting, a biomedical discourse dominates, with doctors and nurses fulfilling the roles of named and designated safeguarding professionals. Supervision for these health professionals, while considered necessary, has a multi-layered system of governance with no clear policies to guide its content and purpose. This article will argue that the inclusion of social work expertise in health-based CP services, through an interprofessional approach to supervision, can offer clarity to the operationalisation of supervision and support integrated service development. A model for supervision, with experienced social workers engaged to supervise named safeguarding professionals, is outlined and informed by a psychodynamic perspective. With both CP and supervision an inherent part of the social work tradition, social workers are well placed to use specialist knowledge and insight within the health setting, through supervision, to strengthen reflective practice in this complex area of service delivery.
“May the Force Be With You”: Narendra Modi and the Celebritization of Indian Politics
Authors: Rai Swapnil 
Published: March 2019

Abstract“May the force be with you” were the Indian Prime Minister Narendra Modi’s parting words as he ended his 2014 address to a rapturous crowd of Indian Americans in New York’s Madison square garden. Modi is the first PM to address the country through his own radio show, actively use social media, as well as technologies such as the 3D hologram. This article examines the ways in which Modi’s celebritized politics is strategically constructed and performed, honing in on Modi’s utilization of media, technology, and popular culture. It interrogates the processes such as the personalization of his political image through social media, the use of film stars to cultivate affect and allure by association, in constructing brand Modi.