bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identification of regulators of the myofibroblast phenotype of primary dermal fibroblasts from early diffuse systemic sclerosis patients
Authors: Chadli Loubna , Sotthewes Britt , Li Kejie , Andersen Stefan N. , Cahir-McFarland Ellen , Cheung Marc , Cullen Patrick , Dorjée Annemarie , de Vries-Bouwstra Jeska K. , Huizinga Tom W. J. , Fischer David F. , DeGroot Jeroen , Viney Joanne L. , Zheng Timothy S. , Aarbiou Jamil , Gardet Agnes 
Published: March 2019

AbstractSystemic sclerosis (SSc or scleroderma) is an auto-immune disease characterized by skin fibrosis. While primary cells from patients are considered as a unique resource to better understand human disease biology, the effect ofin vitroculture on these cells and their evaluation as a platform to identify disease regulators remain poorly characterized. The goal of our studies was to provide insights into the utility of SSc dermal fibroblast primary cells for therapeutic target discovery. The disease phenotypes of freshly isolated andin vitro cultured SSc dermal fibroblasts were characterized using whole transcriptome profiling, alpha smooth muscle actin (ASMA) expression and cell impedance. SSc dermal fibroblasts retained most of the molecular disease phenotype uponin vitroculture for at least four cell culture passages (approximatively 10 cell doublings). We validated an RNA interference high throughput assay that successfully identified genes affecting the myofibroblast phenotype of SSc skin fibroblasts. These genes includedMKL1,RHOAandLOXL2 thatwere previously proposed as therapeutic anti-fibrotic target, andITGA5, that has been less studied in fibrosis biology and may be a novel potential modifier of SSc fibroblast biology. Together our results demonstrated the value of carefully-phenotyped SSc dermal fibroblasts as a platform for SSc target and drug discovery.
Predicting bioavailability change of complex chemical mixtures in contaminated soils using visible and near-infrared spectroscopy and random forest regression
Authors: Cipullo S. , Nawar S. , Mouazen A. M. , Campo-Moreno P. , Coulon F. 
Published: March 2019

AbstractA number of studies have shown that visible and near infrared spectroscopy (VIS-NIRS) offers a rapid on-site measurement tool for the determination of total contaminant concentration of petroleum hydrocarbons compounds (PHC), heavy metals and metalloids (HM) in soil. However none of them have yet assessed the feasibility of using VIS-NIRS coupled to random forest (RF) regression for determining both the total and bioavailable concentrations of complex chemical mixtures. Results showed that the predictions of the total concentrations of polycyclic aromatic hydrocarbons (PAH), PHC, and alkanes (ALK) were very good, good and fair, and in contrast, the predictions of the bioavailable concentrations of the PAH and PHC were only fair, and poor for ALK. A large number of trace elements, mainly lead (Pb), aluminium (Al), nickel (Ni), chromium (Cr), cadmium (Cd), iron (Fe) and zinc (Zn) were predicted with very good or good accuracy. The prediction results of the total HMs were also better than those of the bioavailable concentrations. Overall, the results demonstrate that VIS-NIR DRS coupled to RF is a promising rapid measurement tool to inform both the distribution and bioavailability of complex chemical mixtures without the need of collecting soil samples and lengthy extraction for further analysis.
Iodine nanoparticles enhance radiotherapy of intracerebral human glioma in mice and increase efficacy of chemotherapy
Authors: Hainfeld James F. , Ridwan Sharif M. , Stanishevskiy Yaroslav , Panchal Rahul , Slatkin Daniel N. , Smilowitz Henry M. 
Published: March 2019

AbstractGliomas and other brain tumors have evaded durable therapies, ultimately causing about 20% of all cancer deaths. Tumors are widespread in the brain at time of diagnosis, limiting surgery and radiotherapy effectiveness. Drugs are also poorly effective. Radiotherapy (RT) is limited by dose to normal tissue. However, high-atomic-number elements absorb X-rays and deposit the absorbed dose locally, even doubling (or more) the local dose. Previously we showed that gold nanoparticles (AuNPs) with RT could eradicate some brain tumors in mice and many other preclinical studies confirmed AuNPs as outstanding radioenhancers. However, impediments to clinical translation of AuNPs have been poor clearance, skin discoloration, and cost. We therefore developed iodine nanoparticles (INPs) that are almost colorless, non-toxic, lower cost, and have reasonable clearance, thus overcoming major drawbacks of AuNPs. Here we report the use of iodine nanoparticle radiotherapy (INRT) in treating advanced human gliomas (U87) grown orthotopically in nude mice resulting in a more than a doubling of median life extension compared to RT alone. Significantly, INRT also enhanced the efficacy of chemotherapy when it was combined with the chemotherapeutic agent Doxil, resulting in some longer-term survivors. While ongoing optimization studies should further improve INRT, clinical translation appears promising.
Low C6orf141 Expression is Significantly Associated with a Poor Prognosis in Patients with Oral Cancer
Authors: Yang Cheng-Mei , Chang Hao-Sheng , Chen Hung-Chih , You Jyun-Jie , Liou Huei-Han , Ting Su-Chen , Ger Luo-Ping , Li Sung-Chou , Tsai Kuo-Wang 
Published: March 2019

AbstractC6orf141 (Chromosome 6 open reading frame 141) is a novel gene, and its role in oral cancer progression remains unclear. C6orf141 expression in oral squamous cell carcinoma (OSCC) and adjacent normal tissues from 428 patients was examined through immunohistochemistry (IHC). Our results revealed that C6orf141 expression was significantly reduced in OSCC compared with adjacent normal tissues. Low C6orf141 expression was significantly associated with a poor American Joint Committee on Cancer pathological stage (P < 0.001), T classification (P = 0.002), and pN stage (P = 0.032). Kaplan–Meier curves revealed that low C6orf141 expression was significantly associated with shorter disease-specific survival (DSS) in patients with OSCC (log-rank P = 0.007). Multivariate analysis indicated that low C6orf141 expression was an independent prognostic biomarker for DSS (adjusted hazard ratio = 1.34; 95% confidence interval = 1.10–1.81; P = 0.05). Additionally, ectopic C6orf141 expression could significantly suppress oral cancer cell proliferation, colony formation, and migratory and invasive abilities. Xenograft tumor growth assay revealed that C6orf141 could significantly suppress oral tumor growth in vivo. Our results suggest that C6orf141 plays a novel tumor-suppressive role in oral cancer cell growth and motility. Furthermore, C6orf141 dysfunction could be a potential prognostic biomarker for OSCC and provide new therapeutic strategies in the future.
Lithographically patterned metallic conduction in single-layer MoS2 via plasma processing
Authors: Stanford Michael G. , Lin Yu-Chuan , Sales Maria Gabriela , Hoffman Anna N. , Nelson Christopher T. , Xiao Kai , McDonnell Stephen , Rack Philip D. 
Published: March 2019

AbstractTailoring the electrical transport properties of two-dimensional transition metal dichalcogenides can enable the formation of atomically thin circuits. In this work, cyclic hydrogen and oxygen plasma exposures are utilized to introduce defects and oxidize MoS2 in a controlled manner. This results in the formation of sub-stochiometric MoO3−x, which transforms the semiconducting behavior to metallic conduction. To demonstrate functionality, single flakes of MoS2 were lithographically oxidized using electron beam lithography and subsequent plasma exposures. This enabled the formation of atomically thin inverters from a single flake of MoS2, which represents an advancement toward atomically thin circuitry.
Automatic classification of cells in microscopic fecal images using convolutional neural networks
Authors: Du Xiaohui , Liu Lin , Wang Xiangzhou , Ni Guangming , Zhang Jing , hao Ruqian , Liu Juanxiu , Liu Yong 
Published: March 2019

Abstract
The analysis of fecal-type components for clinical diagnosis is important. The main examination involves the counting of red blood cells (RBCs), white blood cells (WBCs), and molds under the microscopic. With the development of machine vision, some vision-based detection schemes have been proposed. However, these methods have a single target for detection, with low detection efficiency and low accuracy. We proposed an algorithm to identify the visible image of fecal composition based on intelligent deep learning. The algorithm mainly includes region proposal and candidate recognition. In the process of segmentation, we proposed a morphology extraction algorithm in a complex background. As for the candidate recognition, we proposed a new convolutional neural network (CNN) architecture based on Inception-v3 and principal component analysis (PCA). This method achieves high-average Precision of 90.7%, which is better than the other mainstream CNN models. Finally, the images within the rectangle marks were obtained. The total time for detection of an image was roughly 1200 ms. The algorithm proposed in the present paper can be integrated into an automatic fecal detection system.
Identification and analysis of genes associated with papillary thyroid carcinoma by bioinformatics methods
Authors: Zhang Shulong , Wang Quan , Han Qi , Han Huazhong , Lu Pinxiang 
Published: March 2019

Abstract
The molecular mechanism of the occurrence and development of papillary thyroid carcinoma (PTC) has been widely explored, but has not been completely elucidated. The present study aimed to identify and analyze genes associated with PTC by bioinformatics methods. Two independent datasets were downloaded from Gene Expression Omnibus (GEO) database. The differentially expressed genes (DEGs) between PTC tissues and matched non-cancerous tissues were identified using GEO2R tool. The common DEGs in the two datasets were screened out by VennDiagram package, and analyzed by the following tools: KOBAS, Database for Annotation, Visualization, and Integrated Discovery (DAVID), Search tool for the retrieval of interacting genes/proteins (STRING), UALCAN and Gene expression profiling interactive analysis (GEPIA). A total of 513 common DEGs, including 259 common up-regulated and 254 common down-regulated genes in PTC, were screened out. These common up-regulated and down-regulated DEGs were most significantly enriched in cytokine–cytokine receptor interaction and metabolic pathways, respectively. Protein–protein interactions (PPI) network analysis showed that the up-regulated genes: FN1, SDC4, NMU, LPAR5 and the down-regulated genes: BCL2 and CXCL12 were key genes. Survival analysis indicated that the high expression of FN1 and NMU genes significantly decreased disease-free survival of patients with thyroid carcinoma. In conclusion, the genes and pathways identified in the current study will not only contribute to elucidating the pathogenesis of PTC, but also provide prognostic markers and therapeutic targets for PTC.
Compact high Q bandpass filter by using substrate integrated waveguide and split rings capacitive load post
Authors: Jelodar A. , Nooraei Yeganeh A. , Sedighy S.H. 
Published: March 2019

A substrate integrated waveguide cavity filter is designed by loading with two split rings capacitive posts. Using these split rings posts results in high quality factor, low insertion loss (2.1 dB), very narrow bandwidth (2%) at 4.6 GHz centre frequency and compact (0.97×0.5 λg2) bandpass filter structure. The filter measured results are in good agreement with the simulation ones which prove the idea.
Neural optical probe with monolithically integrated intensity‐monitoring μLED and polymer waveguide for optogenetics
Authors: Sekiguchi H. , Yasunaga H. , Tsuchiyama K. , Nitta R. 
Published: March 2019

A neural optical probe that is monolithically integrated with a micro‐light‐emitting diode (μLED), a micro‐photodiode (μPD), and a cyclo‐olefin polymer (COP) waveguide is a novel optogenetic tool that can suppress the influence of heat while utilising the advantage of LED. Although a μLED temperature increased by 0.3°C at a light output of 100 mW/mm2, heat did not spread to the optical stimulation area. The emission from the μLED is propagated through a 2 mm long COP waveguide, suggesting that the μLED placed on the outside of the brain can optically stimulate the deep region of brain tissue. Furthermore, it is successfully detected at the μPD located close to the μLED, which proved that the μPD was effective to monitor the light output of the μLED.
Transferência tendínea do grande dorsal com enxerto tendíneo homólogo para as lesões irreparáveis do manguito rotador: técnica cirúrgica
Authors: Miyazaki Alberto Naoki , Checchia Caio Santos , de Castro Lopes Wagner , Fonseca Filho João Manoel , Sella Guilherme do Val , da Silva Luciana Andrade 
Published: March 2019

ResumoNo contexto do tratamento cirúrgico dos pacientes jovens com lesões irreparáveis da porção posterossuperior do manguito rotador, a técnica mais usada é a transferência do tendão do grande dorsal para a porção superolateral do tubérculo maior, conforme descrita e preconizada por Gerber et al. Entretanto, duas características dessa técnica podem levar a resultados ruins e complicações: (i) a deiscência da origem do deltoide, que ocorre devido à sua violação durante a criação da via em golpe de sabre e (ii) a ruptura pós-operatória da inserção da transferência. Na tentativa de solucionar esses dois problemas, as seguintes modificações foram feitas à técnica cirúrgica original. Por meio de uma única via deltopeitoral, o tendão do grande dorsal é isolado e desinserido do úmero. Ele é então alongado e reforçado com um enxerto tendíneo homólogo, transferido ao redor do úmero e fixado à porção superolateral do tubérculo maior. Não foi usada imobilização pós-operatória com órtese toracobraquial rígida.
Extraposition in learner and expert writing
Authors: Larsson Tove , Kaatari Henrik 
Published: March 2019

Abstract
Subject extraposition (e.g. it is important to remember) is generally considered to be a formal
construction that learners, whose writing is often said to be overly informal, have been found to struggle with. This study
investigates to what extent register and text type can be used to explore learners’ reportedly “informal” use of this
construction. Learner writing is compared to expert writing from several different registers and to native-speaker student
writing. The results show that there are important differences across both registers and text types. Furthermore, while the
learners’ use is most like that of the experts’ academic writing, certain similarities to the non-academic registers were also
noted. The results additionally suggest that earlier claims about the informal status of learner writing seem mainly to have been
influenced by the text types included in the corpora previously investigated.
Impact of Academic Detailing on Benzodiazepine use among Veterans with Posttraumatic Stress Disorder
Authors: Bounthavong Mark , Lau Marcos K. , Popish Sarah J. , Kay Chad L. , Wells Daina L. , Himstreet Julianne E. , Harvey Michael A. , Christopher Melissa L. D. 
Published: March 2019

Background Benzodiazepine use in the US Veterans Administration (VA) has been decreasing; however, a small number of veterans with posttraumatic stress disorder (PTSD) continue to receive benzodiazepine. Academic detailing, a targeted-educational outreach intervention, was implemented at VA to help reduce the disparity between existing and evidence-based practices, including the reduction in benzodiazepine use in veterans with PTSD. Since evidence to support the national implementation of academic detailing in this clinical scenario was scarce, we performed a quality improvement evaluation on academic detailing's impact on benzodiazepine use in veterans with PTSD. Methods A retrospective cohort design was used to evaluate the impact of academic detailing on benzodiazepine prescribing in veterans with PTSD from January 1, 2016, to December 31, 2016. Providers exposed to academic detailing (AD-exposed) were compared with providers unexposed to academic detailing (AD-unexposed) using generalized estimating equations (GEEs) controlling for baseline covariates. Secondary aims evaluated academic detailing's impact on average lorazepam equivalent daily dose (LEDD), total LEDD, and benzodiazepine day supply. Results Overall, there was a decrease in the prevalence in benzodiazepine use in veterans with PTSD from 115.5 to 103.3 per 1000 population ( P < .001). However, the decrease was greater in AD-exposed providers (18.37%; P < .001) compared with AD-unexposed providers (8.74%; P < .001). In the GEE models, AD-exposed providers had greater reduction in the monthly prevalence of veterans with PTSD and a benzodiazepine prescription compared with AD-unexposed providers, by −1.30 veterans per 1000 population (95% confidence interval [CI]: −2.14, −0.46). Similar findings were reported for the benzodiazepine day supply; however, no significant differences were reported for total and average LEDD. Conclusions Although benzodiazepine use has been decreasing in veterans with PTSD, opportunities to improve prescribing continue to exist at the VA. In this quality improvement evaluation, AD-exposed providers were associated with a greater reduction in the prevalence of veterans with PTSD and a benzodiazepine prescription compared with AD-unexposed providers.
Objective Comparison of Nasojugal Fold Depth and Lower Eyelid Length After Fat Excision Versus Fat Transpositional Lower Blepharoplasty
Authors: Ramesh Sathyadeepak , Goldberg Robert A , Wulc Allan E , Brackup Alan B 
Published: March 2019

Abstract

Background
Lower blepharoplasty is one of the most commonly performed aesthetic surgeries in the world. However, there are no studies to directly compare patients who had fat excision vs fat transposition.

Objectives
The authors sought to compare and contrast aesthetic results of fat excisional and fat transpositional lower blepharoplasty.

Methods
A retrospective review was conducted of 60 patients (120 eyelids) who underwent transconjunctival lower blepharoplasty, either with fat excision or fat transposition into a preperiosteal plane. Marginal reflex distance-2, lower eyelid length, nasojugal fold depth, and pretarsal orbicularis definition were measured.

Results
Mean follow-up was 5.6 months. Mean marginal reflex distance-2 did not significantly differ after either fat excision or fat transposition. Mean lower lid length decreased after fat excision only (P &lt; 0.001), and postoperative fat excision patients had a shorter lower eyelid length than patients who underwent fat transposition (13.5 ± 2.1 mm vs 16.1 ± 1.9 mm, P &lt; 0.0001). Pretarsal orbicularis definition increased after both surgeries (P &lt; 0.001), and the groups did not differ (1.0 ± 0.8 vs 1.1 ± 0.9, not significant). Mean nasojugal fold depth was effaced after surgery in both groups (P &lt; 0.001), although the nasojugal fold was significantly more effaced after fat transposition (1.5 ± 0.7 vs 0.48 ± 0.6, P &lt; 0.001).

Conclusions
In lower blepharoplasty, fat excision resulted in a shorter lower eyelid, and fat transposition resulted in a more effaced lid-cheek junction. Surgeons should be able to balance both techniques to deliver a customized aesthetic result.

Level of Evidence: 3
Collaborative Task Offloading with Computation Result Reusing for Mobile Edge Computing
Authors: Zhang Zikai , Wu Jigang , Chen Long , Jiang Guiyuan , Lam Siew-Kei 
Published: March 2019

AbstractThe task offloading problem, which aims to balance the energy consumption and latency for Mobile Edge Computing (MEC), is still a challenging problem due to the dynamic changing system environment. To reduce energy while guaranteeing delay constraint for mobile applications, we propose an access control management architecture for 5G heterogeneous network by making full use of Base Station’s storage capability and reusing repetitive computational resource for tasks. For applications that rely on real-time information, we propose two algorithms to offload tasks with consideration of both energy efficiency and computation time constraint. For the first scenario, i.e. the rarely changing system environment, an optimal static algorithm is proposed based on dynamic programming technique to get the exact solution. For the second scenario, i.e. the frequently changing system environment, a two-stage online algorithm is proposed to adaptively obtain the current optimal solution in real time. Simulation results demonstrate that the exact algorithm in the first scenario runs 4 times faster than the enumeration method. In the second scenario, the proposed online algorithm can reduce the energy consumption and computation time violation rate by 16.3% and 25% in comparison with existing methods.
Adipolin/CTRP12 protects against pathological vascular remodelling through suppression of smooth muscle cell growth and macrophage inflammatory response
Authors: Ogawa Hayato , Ohashi Koji , Ito Masanori , Shibata Rei , Kanemura Noriyoshi , Yuasa Daisuke , Kambara Takahiro , Matsuo Kazuhiro , Hayakawa Satoko , Hiramatsu-Ito Mizuho , Otaka Naoya , Kawanishi Hiroshi , Yamaguchi Shukuro , Enomoto Takashi , Abe Takaya , Kaneko Mari , Takefuji Mikito , Murohara Toyoaki , Ouchi Noriyuki 
Published: March 2019

AbstractAimsSecreted factors produced by adipose tissue are involved in the pathogenesis of cardiovascular disease. We previously identified adipolin, also known as C1q/TNF-related protein 12, as an insulin-sensitizing adipokine. However, the role of adipolin in vascular disease remains unknown. Here, we investigated whether adipolin modulates pathological vascular remodelling.Methods and resultsAdipolin-knockout (APL-KO) and wild-type (WT) mice were subjected to wire-induced injury of the femoral artery. APL-KO mice showed increased neointimal thickening after vascular injury compared with WT mice, which was accompanied by an enhanced inflammatory response and vascular cell proliferation in injured arteries. Adipolin deficiency also led to a reduction in transforming growth factor-β (TGF-β) 1 protein levels in injured arteries. Treatment of cultured macrophages with adipolin protein led to a reduction in lipopolysaccharide-stimulated expression of inflammatory mediators, including tumour necrosis factor (TNF)-α, interleukin (IL) 6, and monocyte chemotactic protein (MCP)-1. These effects were reversed by inhibition of TGF-β receptor II (TGF-βRII)/Smad2 signalling. Adipolin also reduced platelet-derived growth factor (PDGF)-BB-stimulated proliferation of vascular smooth muscle cells (VSMCs) through a TGF-βRII/Smad2-dependent pathway. Furthermore, adipolin treatment significantly increased TGF-β1 concentration in media from cultured VSMCs and macrophages.ConclusionThese data indicate that adipolin protects against the development of pathological vascular remodelling by attenuating macrophage inflammatory responses and VSMC proliferation.