bluuebunny/crossref_metadata_2025_split huggingface dataset:
Global Spatial and Temporal Variation of Cd:P in Euphotic Zone Particulates
Authors: Bourne H. L. , Bishop J. K. B. , Lam P. J. , Ohnemus D. C. 
Published: June 2018

AbstractConcentrations of Cd and P were determined in particle samples collected using the multiple unit large volume in situ filtration system (MULVFS) from 50 profiles at 34 different locations throughout the Atlantic, Pacific, and Southern Oceans since 1991. Consistent methodology has been used. This data set of Cd:P in size fractionated particles gives insight into the processes that lead to differences in regional Cd:P particle values as well as how the formation and remineralization of these particles lead to dissolved deep water ratios that increase from the North Atlantic to the North Pacific. With large spatial and temporal variation, this data set allows us to study the effects of an El Niño, upwelling, large‐scale in situ Fe fertilization, low‐oxygen conditions, and seasonal variation on the Cd:P in particles. Overall, Cd:P tends to be higher (~1–2 mmol/mol) in particles gathered in biologically dynamic waters and is much lower (typically ~0.1 mmol/mol) in oligotrophic regions. Using multiple linear regression analysis, we investigate how euphotic zone parameters important to photosynthesis including nitrate, phosphate, silicate, temperature, and euphotic zone depth affect the Cd:P ratio in particles. Using the results of the analysis, we create global seasonal maps of predicted particulate Cd:P distributions. We find that three factors—local dissolved nitrate, silicate concentrations, and euphotic zone depth—can predict 59% of the variation in particulate Cd:P. We verified our projections using in situ filtration samples collected during GEOTRACES expeditions GA03 (North Atlantic) and GP16 (South Pacific).
Seismicity Distribution Near a Subducting Seamount in the Central Ecuadorian Subduction Zone, Space‐Time Relation to a Slow‐Slip Event
Authors: Segovia Mónica , Font Yvonne , Régnier Marc , Charvis Philippe , Galve Audrey , Nocquet Jean‐Mathieu , Jarrín Paul , Hello Yann , Ruiz Mario , Pazmiño Andres 
Published: June 2018

AbstractA temporary onshore‐offshore seismic network deployed during the 2‐year period of the Observación SISmológica en ECuador project provides a detailed and well‐focused image of the seismicity for magnitudes as low as 2.1 at the Central Ecuadorian subduction zone. During this 2‐year experiment, the shallow and locked subduction patch shows little evidence of background seismicity that instead occurred downdip of the coupled patch at ~20‐km depth. In this region, seismicity is possibly controlled by the crustal faults bounding the sedimentary basin of Manabí and the rheology of the upper plate. The dip angle of the interplate contact zone, defined by a smooth interpolation through the hypocenters of thrust events, is consistent with a progressive increase from 6° to 25° from the trench to 20‐km depth. Offshore, a seismic swarm, concomitant with a slow‐slip event rupturing the highly coupled subduction megathrust, highlights the reactivation of secondary active faults within the thickened crust of the subducting Carnegie Ridge at the leading edge of a large oceanic seamount.
The Structure of Southwest Taiwan: The Development of a Fold‐and‐Thrust Belt on a Margins Outer Shelf and Slope
Authors: Biete Cristina , Alvarez‐Marron Joaquina , Brown Dennis , Kuo‐Chen Hao 
Published: June 2018

AbstractThe southwest Taiwan fold‐and‐thrust belt is forming on the outer shelf and slope of the Eurasian continental margin. It comprises a roughly N‐S striking, west verging imbricate thrust system that has been developing since the Late Miocene. Here we present the results of new surface geological mapping from which we construct balanced and restored cross sections and along‐strike sections. From these we compile maps of the basal thrust, thrust branch lines and, where possible, stratigraphic cutoffs. To interpret the structure in the subsurface and beneath the basal thrust, we use a P wave velocity of 5.2 km/s as a proxy for the top of the Mesozoic basement. We divide the southwest Taiwan fold‐and‐thrust belt into a number of thrust sheets that form the basis of our description and interpretations. From these data we interpret the 3‐D structure of the fold‐and‐thrust belt and the influence that the structure and morphology of the continental margin is having on its development. We show that there is a significant along‐strike change in the structure. This change takes place across a transverse zone that is composed of a suite of structures at the surface. We suggest that this transverse zone has a causal relationship with variations in the geometry of the basal thrust which in turn is related to (possibly fault bounded) basement highs and lows that are inherited from the continental margin.
Architecture and Kinematics of the Constance‐Frick Trough (Northern Switzerland): Implications for the Formation of Post‐Variscan Basins in the Foreland of the Alps and Scenarios of Their Neogene Reactivation
Authors: Madritsch Herfried , Naef Henry , Meier Beat , Franzke Hans Joachim , Schreurs Guido 
Published: June 2018

AbstractPost‐Variscan basins are commonly inferred to represent important precursor structures of later extensional and contractional tectonic events in the foreland of the European Alps. Nevertheless, their structural characteristics are typically poorly constrained. Our investigation sheds new light on the architecture and kinematics of the Constance‐Frick Trough (CFT) in Northern Switzerland. According to our analysis of an extensive and revised 2‐D reflection seismic data set, the ENE‐WSW striking CFT is divided into an eastern segment and a western segment characterized by opposing half‐graben geometries. The transition between the two segments coincides with the prolongation of a preexisting WNW‐ESE trending strike‐slip fault zone exposed in the adjacent Black Forest Massif to the north. Field‐based analysis of outcrop‐scale faults in the latter area implies that the minimum horizontal stress during the formation of the CFT was roughly oriented NE‐SW, which is oblique to the trough axis. While previously published analogue models imply that some characteristics of the CFT could be explained by lateral linkage of graben segments under oblique extension, the pronounced half‐graben geometry of the CFT suggests that low‐angle normal faulting may also have contributed to trough formation. The observed structural complexities of the CFT and uncertainties regarding its deep structure must be taken into account for interpretations of similar Late Paleozoic basins inferred in the subsurface of the northern Alpine foreland basin, in particular, concerning scenarios of their Neogene reactivation during Alpine orogeny.
Basic Dykes Crosscutting the Crystalline Basement of Valsugana (Italy): New Evidence of Early Triassic Volcanism in the Southern Alps
Authors: Bianchini Gianluca , Natali Claudio , Shibata Tomoyuki , Yoshikawa Masako 
Published: June 2018

AbstractBasic dykes crosscutting the crystalline basement in Valsugana (Southern Alps, Italy) have been investigated for the first time in the framework of the known tectonomagmatic cycles. Petrographic observations and bulk rock analyses suggest a serial affinity variable between calc‐alkaline (subordinate) and shoshonitic (prevalent), which are generally ascribed to a convergent plate setting. This is confirmed by Sr‐Nd‐Pb isotopic analyses that display extreme values that are often observed in postcollisional settings. A bulk rock Rb‐Sr pseudoisochron suggests an age of the magmatism around 260 Ma, whereas K‐Ar datings yield ages between 227 and 251 Ma, suggesting that these dykes plausibly represent a transition between the Permian and the Triassic volcanic episodes that are known in neighboring sectors of the Southern Alps. Considering that Permo‐Triassic active subduction beneath the South Alpine is scarcely constrained, we ascribe the metasomatism of the related mantle sources to the Variscan cycle, proposing that magma genesis was delayed with respect to the time of the active subduction(s). According to recent reconstructions, parts of southeastern Europe, including the South Alpine domain, were formed by the breakup of the northern Gondwana margin from the Late Cambrian, in connection with important transtensional movements, leaving rifted continental basins or narrow oceanic seaways. In our view, the subduction processes that induced metasomatism in mantle sources of the South Alpine region occurred in the connection with the subsequent (Carboniferous?) consumption of lithosphere of these basins, a framework that is compatible with pervasive recycling of continental crust components within the mantle wedge. Then, calc‐alkaline/shoshonite magmatism was triggered in the Early Triassic by postcollisional extensional tectonics that followed the Variscan orogenic cycle.
Spatial Patterns of Water Age: Using Young Water Fractions to Improve the Characterization of Transit Times in Contrasting Catchments
Authors: Lutz S. R. , Krieg R. , Müller C. , Zink M. , Knöller K. , Samaniego L. , Merz R. 
Published: June 2018

AbstractTransit time distributions (TTDs) are crucial descriptors of flow and transport processes in catchments, which can be determined from stable water isotope data. Recently, the young water fraction (Fyw) has been introduced as an additional metric derivable from seasonal isotope cycles. In this study, we calculated Fyw and TTDs using monthly isotope data from 24 contrasting subcatchments in a mesoscale catchment (3,300 km2) in Germany. Fyw ranged from 0.01 to 0.27 (mean = 0.11) and was smallest in mountainous catchments. Assuming gamma‐shaped TTDs, we determined stationary TTDs with the convolution integral method for each subcatchment. The convolution integral was first calibrated against the isotope data only (i.e., traditional calibration) and, second, using a multiobjective calibration with the Fyw estimates as an additional constraint. This yielded largely differing TTD parameters even for neighboring catchments, with Fyw values below 0.1 generally involving a delayed peak in TTDs (i.e., gamma‐distribution shape parameter > 1). While the traditional calibration resulted in large uncertainties in TTD parameters, these uncertainties were reduced with the multiobjective calibration, thereby improving the assessment of mean transit times (2 years on average, ranging between 9.6 months and 5.6 years). This highlights the need for uncertainty assessment when using simple isotope models and shows that the traditional calibration might not yield an optimum solution in that it may give a TTD nonconsistent with Fyw. Given the robustness of Fyw estimates, isotope models should thus aim at accurately describing both Fyw and measured isotope data in order to improve the description of flow and transport in catchments.
Significant Role of Orography in Shaping the Northern Hadley Circulation and Its Poleward Expansion During Boreal Summer
Authors: Cheng Jianbo , Xu Zhihang , Hu Po , Hou Xiaoya , Gao Chenbin , Hu Shujuan , Feng Guolin 
Published: June 2018

AbstractThe southward circulation embedded within the conventional northward circulation of the Northern Hemisphere (NH) Hadley circulation (HC) is defined as a minor circulation. Motivated by the vital influence of this minor circulation, we investigate whether the minor circulation in the NH HC is a robust feature during boreal summer (June to September). Our results show that although the uncorrected NH HC includes the minor circulation, the corrected NH HC is characterized as one single northward circulation regardless of the reanalysis data set and method used. This finding implies that the minor circulation concept is introduced by not considering orography (i.e., surface pressure). After correction, the significance and degree of the poleward expansion of the NH HC during boreal summer are obviously reduced. We also note that regional biases in the meridional wind can result in considerable biases throughout the entire NH HC via the process of vertical integration.
Soft tissue sarcoma affecting the right shoulder of a man with paraplegia from a remote traumatic spinal cord injury: a case report
Authors: Franz Colin K. , Dalamagkas Kyriakos , Jordan Lewis A. , Spill Gayle R. 
Published: June 2018

Abstract

Introduction
People with spinal cord injury (SCI) are getting older due to a combination of increased life expectancy and older age at the time of injury. This trend makes it more likely for these patients to have other chronic health conditions including cancer. Inevitably relatively rare cancers such as soft tissue sarcomas (STS), which are more common with advancing age, will occur in some SCI patients. The present case represents the first report of a limb STS in a patient with chronic paraplegia from a traumatic SCI.

Case presentation
We report a case of a 50-year-old right handed male with a T6 chronic, complete SCI (American Spinal Injury Association Impairment Scale A) who presented with a large mass involving his right shoulder musculature that was determined to be a high grade spindle cell sarcoma. The patient was followed closely by Physiatry over an approximately 6-month time course including prior to his tumor diagnosis, during the pre-radiation and pre-surgical planning phase, and then post-operatively for his acute inpatient rehabilitation. He was successfully discharged home to live alone in his accessible apartment complex.

Discussion
This case is the first ever reported case of a person living with a traumatic SCI who subsequently developed a limb STS. In addition to its novelty, this case illustrates how health conditions such as rare cancers are presenting more often as the chronic SCI population is getting older, which creates both unique diagnostic and management challenges for cancer rehabilitation specialists.
CNS relapse in patients with DLBCL treated with lenalidomide plus R-CHOP (R2CHOP): analysis from two phase 2 studies
Authors: Ayed Ayed O. , Chiappella Annalisa , Pederson Levi , Laplant Betsy R. , Congiu Angela Giovanna , Gaidano Gianluca , Spina Michele , Re Alessandro , Cavallo Federica , Musuraca Gerardo , Macon William R. , Witzig Thomas , Vitolo Umberto , Nowakowski Grzegorz S. 
Published: June 2018

AbstractCentral nervous system (CNS) relapse of diffuse large B-cell lymphoma (DLBCL) is a devastating event occurring in ~ 5% of patients treated with R-CHOP. We hypothesized that adding lenalidomide to R-CHOP (R2CHOP) may decrease the risk of CNS relapse. We analyzed records for patients with DLBCL from two R2CHOP trials. We assessed variables pertinent to the CNS-International Prognostic Index (CNS-IPI) scoring system and classified patients into groups of low, intermediate, and high risk of CNS relapse. The 2-year CNS relapse rate for each risk group was estimated using the Kaplan–Meier method and compared with reported rates in cohorts treated with contemporary chemoimmunotherapy. A total of 136 patients were included. Mean age was 65 and median follow-up was 48.2 months. 10.3, 71.3, and 18.4% of patients were classified into low, intermediate, and high-risk CNS-IPI groups, respectively. Only one of 136 patients developed CNS relapse, corresponding to an incidence of 0.7% and an estimated 2-year CNS relapse rate of 0.9% for the entire R2CHOP cohort. The estimated 2-year CNS relapse rates for the low, intermediate, and high-risk groups were 0, 0, and 5.0%, respectively. Frontline therapy with R2CHOP in patients with DLBCL is associated with a lower-than-expected rate of CNS relapse.
Splanchnic vein thrombosis in myeloproliferative neoplasms: treatment algorithm 2018
Authors: Finazzi Guido , De Stefano Valerio , Barbui Tiziano 
Published: June 2018

AbstractMyeloproliferative neoplasms (MPNs) are a leading cause of splanchnic vein thrombosis (SVT). SVT is observed in all MPNs and frequently affects young patients. Therapy should be addressed to three main goals: preventing thrombosis recurrence, managing the underlying MPN, and supporting liver dysfunction. Life-long oral anticoagulation with vitamin K antagonists is the cornerstone of the antithrombotic treatment. However, recurrences of SVT or other thrombosis may occur in 15–20% of patients. Direct oral anticoagulants can represent an alternative and preliminary data encourage comparative studies. Survival of patients with SVT in MPN is primarily influenced by the natural history of the underlying neoplasms, rather than the SVT event. An aggressive management is recommended and a treatment algorithm based on the different MPN subtypes is proposed. Hydroxyurea is the cytoreductive drug of choice in polycythemia vera and essential thrombocythemia, whereas ruxolitinib is indicated in intermediate and high-risk patients with myelofibrosis and in PV patients resistant or intolerant to hydroxyurea. The management of SVT in MPNs requires a multidisciplinary approach that may include a hematologist, a gastroenterologist, an interventional radiologist, and a surgeon. In the case of clinical deterioration despite pharmacological therapy, patients with SVT should be considered for invasive procedures or liver transplantation.
Enumerating all possible biosynthetic pathways in metabolic networks
Authors: Ravikrishnan Aarthi , Nasre Meghana , Raman Karthik 
Published: June 2018

AbstractExhaustive identification of all possible alternate pathways that exist in metabolic networks can provide valuable insights into cellular metabolism. With the growing number of metabolic reconstructions, there is a need for an efficient method to enumerate pathways, which can also scale well to large metabolic networks, such as those corresponding to microbial communities. We developed MetQuest, an efficient graph-theoretic algorithm to enumerate all possible pathways of a particular size between a given set of source and target molecules. Our algorithm employs a guided breadth-first search to identify all feasible reactions based on the availability of the precursor molecules, followed by a novel dynamic-programming based enumeration, which assembles these reactions into pathways of a specified size producing the target from the source. We demonstrate several interesting applications of our algorithm, ranging from identifying amino acid biosynthesis pathways to identifying the most diverse pathways involved in degradation of complex molecules. We also illustrate the scalability of our algorithm, by studying large graphs such as those corresponding to microbial communities, and identify several metabolic interactions happening therein. MetQuest is available as a Python package, and the source codes can be found at https://github.com/RamanLab/metquest.
Cluster-assembled zirconia substrates promote long-term differentiation and functioning of human islets of Langerhans
Authors: Galli Alessandra , Maffioli Elisa , Sogne Elisa , Moretti Stefania , Di Cairano Eliana Sara , Negri Armando , Nonnis Simona , Norata Giuseppe Danilo , Bonacina Fabrizia , Borghi Francesca , Podestà Alessandro , Bertuzzi Federico , Milani Paolo , Lenardi Cristina , Tedeschi Gabriella , Perego Carla 
Published: June 2018

AbstractEx vivo expansion and differentiation of human pancreatic β-cell are enabling steps of paramount importance for accelerating the development of therapies for diabetes. The success of regenerative strategies depends on their ability to reproduce the chemical and biophysical properties of the microenvironment in which β-cells develop, proliferate and function. In this paper we focus on the biophysical properties of the extracellular environment and exploit the cluster-assembled zirconia substrates with tailored roughness to mimic the nanotopography of the extracellular matrix. We demonstrate that β-cells can perceive nanoscale features of the substrate and can convert these stimuli into mechanotransductive processes which promote long-term in vitro human islet culture, thus preserving β-cell differentiation and function. Proteomic and quantitative immunofluorescence analyses demonstrate that the process is driven by nanoscale topography, via remodelling of the actin cytoskeleton and nuclear architecture. These modifications activate a transcriptional program which stimulates an adaptive metabolic glucose response. Engineered cluster-assembled substrates coupled with proteomic approaches may provide a useful strategy for identifying novel molecular targets for treating diabetes mellitus and for enhancing tissue engineering in order to improve the efficacy of islet cell transplantation therapies.
Genetic variants in systemic lupus erythematosus susceptibility loci, XKR6 and GLT1D1 are associated with childhood-onset SLE in a Korean cohort
Authors: Joo Young Bin , Lim Jiwoo , Tsao Betty P. , Nath Swapan K. , Kim Kwangwoo , Bae Sang-Cheol 
Published: June 2018

AbstractImpact of genetic variants on the age of systemic lupus erythematosus (SLE) onset was not fully understood. We investigated a cumulative effect of SLE-risk variants on the age of SLE onset and scanned genome-wide SNPs to search for new risk loci of childhood-onset SLE (cSLE). We analyzed 781 Korean single-center SLE subjects who previously genotyped by both Immunochip and genome-wide SNP arrays. Individual genetic risk scores (GRS) from well-validated SLE susceptibility loci were calculated and tested for their association with cSLE (<16 years at onset). Single-variant association tests were performed using a multivariable logistic regression adjusting for population stratification. GRS from SLE susceptibility loci was significantly higher in cSLE than aSLE (p = 1.23 × 10−3). Two SNPs, rs7460469 inXKR6(p = 1.26 × 10−8, OR = 5.58) and rs7300146 inGLT1D1p = 1.49 × 10−8, OR = 2.85), showed the most significant associations with cSLE. The model consisting of GRS of SLE and two newly identified loci showed an area under curve (AUC) of 0.71 in a receiver operating characteristics (ROC) curve for prediction of cSLE. In conclusion, cSLE is associated with a high cumulative SLE-risk effect and two novel SNPs rs7460469 and rs7300146, providing the first predictive model for cSLE in Koreans.
Direct methanol synthesis from methane in a plasma-catalyst hybrid system at low temperature using metal oxide-coated glass beads
Authors: Lee Heesoo , Kim Do Heui 
Published: June 2018

AbstractA plasma-catalyst hybrid system was used to synthesize methanol directly from methane. A dielectric barrier discharge (DBD) plasma combined with the catalyst was introduced in order to overcome the difficulties of catalyst-only batch reactions such as high reaction pressure and separation of liquid product. Of the transition metal oxides, Mn2O3-coated glass bead showed the highest methanol yield of about 12.3% in the plasma-catalyst hybrid system. The reaction temperature was maintained below 100 °C due to the low plasma input power (from 1.3 kJ/L to 4.5 kJ/L). Furthermore, the reactivity of the catalyst was maintained for 10 hr without changing the selectivity. The results indicated that the plasma-induced OH radical might be produced on the Mn2O3 catalyst, which led to methanol synthesis.