bluuebunny/crossref_metadata_2025_split huggingface dataset:
Layers of Cryptic Genetic Variation Underlie a Yeast Complex Trait
Authors: Lee Jonathan T , Coradini Alessandro L V , Shen Amy , Ehrenreich Ian M 
Published: February 2019

AbstractTo better understand cryptic genetic variation, Lee et al. comprehensively map the genetic basis of a trait that is typically suppressed in a yeast cross. By determining how three different genetic perturbations give rise...Cryptic genetic variation may be an important contributor to heritable traits, but its extent and regulation are not fully understood. Here, we investigate the cryptic genetic variation underlying a Saccharomyces cerevisiae colony phenotype that is typically suppressed in a cross of the laboratory strain BY4716 (BY) and a derivative of the clinical isolate 322134S (3S). To do this, we comprehensively dissect the trait’s genetic basis in the BYx3S cross in the presence of three different genetic perturbations that enable its expression. This allows us to detect and compare the specific loci that interact with each perturbation to produce the trait. In total, we identify 21 loci, all but one of which interact with just a subset of the perturbations. Beyond impacting which loci contribute to the trait, the genetic perturbations also alter the extent of additivity, epistasis, and genotype–environment interaction among the detected loci. Additionally, we show that the single locus interacting with all three perturbations corresponds to the coding region of the cell surface gene FLO11. While nearly all of the other remaining loci influence FLO11 transcription in cis or trans, the perturbations tend to interact with loci in different pathways and subpathways. Our work shows how layers of cryptic genetic variation can influence complex traits. Here, these layers mainly represent different regulatory inputs into the transcription of a single key gene.
Fractura de clavícula. Técnica mínimamente invasiva. [Minimally invasive approach for clavicular fractures]
Authors: Perrone Juan Martín , Petrucelli Eliana , Balmaceda Martín , Sarmiento Hugo , Belluschi Guillermo , Ferrando Ángel Alberto , Andreozzi Roberto 
Published: February 2019

Objetivo: Describir la técnica quirúrgica mínimamente invasiva con placa regional bloqueada para fracturas mediodiafisarias de clavícula y mostrar nuestros resultados clínicos y radiológicos.Materiales y Métodos: Se evaluó, en forma retrospectiva, a 15 pacientes (12 hombres y 3 mujeres, media de la edad, 32.4 años [rango 17-51]) con fractura de clavícula, tratados con reducción y osteosíntesis con placa superior bloqueada anatómica mediante una técnica mínimamente invasiva. Según la clasificación de Allman, 12 pacientes tenían fractura de clavícula tipo I y tres, de tipo II.Resultados: El tiempo promedio de cirugía fue de 53 minutos (rango 51-65). Se logró la consolidación de todas las fracturas en un promedio de 13.3 semanas (rango 12-15). No hubo seudoartrosis ni consolidaciones viciosas. El puntaje promedio de Constant fue de 98 (rango 95-100). Todos los pacientes se manifestaron satisfechos con los resultados estéticos y funcionales.Conclusiones: Este estudio demuestra que la técnica mínimamente invasiva para las fracturas mediodiafisarias de clavícula, utilizando placas regionales anatómicas bloqueadas superiores, puede ser un procedimiento reproducible y una alternativa a las técnicas quirúrgicas convencionales. Además, los resultados clínicos y radiológicos satisfactorios se obtuvieron sin complicaciones mayores y sin disestesias en la zona de la herida. ABSTRACTObjectives: To describe the minimally invasive locking plate approach for midshaft clavicular fractures and report our radiographic and clinical results.Methods: We retrospectively evaluated fifteen patients (12 men and 3 women, mean age: 32.4 years [range 17-51]) with clavicular fractures who underwent minimally invasive superior locking plate osteosynthesis and reduction. According to the Allman classification of clavicular fractures, 12 patients had a type I fracture, while 3 had a type II fracture.Results: The average operating time was 53 minutes (range 51-65). Union was achieved in all patients in an average of 13.3 weeks (range 12-15). Patients were satisfied with cosmetic and functional results.Conclusions: This study shows that the minimally invasive superior locking plate approach for midshaft clavicular fractures can be a reproducible procedure and an alternative to conventional surgical approaches. Clinical and radiological results were achieved without major complications or wound dysesthesia.
Microstructural characterization of titanium alloy Ti6Al4V thermally oxidized/Caracterización microestructural de la aleación de titanio Ti6Al4V oxidada térmicamente
Authors: Cely Bautista Ma. Mercedes , Jaramillo Colpas Javier , Romero Mejía Ivan , Pinilla Navarro Oscar , Siado Guillen Andres 
Published: February 2019

El objetivo de este artículo es analizar el efecto de la oxidación térmica en el cambio microestructural de propiedades mecánicas de la aleación Ti6Al4V. Las muestras de titanio fueron sometidas a tratamiento de oxidación térmica entre 450°C y 850°C por espacio de 2 horas y enfriamiento lento. La morfología superficial fue analizada mediante Microscopía óptica, Microscopía electrónica de barrido, Difracción de rayos X y Análisis de dureza. Con la oxidación térmica se generó una película de óxido tipo TiO2, la cual incrementó su espesor con la temperatura, de igual forma con este aumento de temperatura la dureza del material aumentó en un 40% a 850°C con respecto al material sin tratamiento. Los resultados además mostraron que a partir de 800°C ya se muestra en su totalidad estructuras de rutilo en la superficie de las muestras.
Complement-Inhibiting Therapy of Atypical Haemolytic Uremic Syndrome in a Patient With Factor H Mutation
Authors: Lupan Irina N. , Pischalnikov Alexander Yu. , Emirova Hadizha M. , Stolyarevich Ekaterina S. , Volyansky Alexander M. , Glukhova Larisa V. 
Published: February 2019

Atypical haemolytic uremic syndrome (aHUS) is an extremely rare pathology with the development of complement-mediated thrombotic microangiopathy (TMA). Before eculizumab, a humanized IgG monoclonal antibody to the complement component C5, the prognosis of total and renal survival with aHUS was unfavourable due to the high probability of death and the development of end-stage chronic renal failure in surviving patients. This article presents a clinical observation of a patient with aHUS who had an identified heterozygous factor H (CFH) mutation — c.3653G>A(p.Cys1218Tyr), and two heterozygous variants of polymorphism in the same gene — c.2016A>G; c.2808G>T. Despite the achievement of haematological remission of TMA against the background of plasma therapy, the child developed dialysis-dependent renal failure. Treatment with eculizumab in a patient with chronic kidney damage provided a significant improvement in their function, maintaining a stable remission and improving the quality of life of the patient with aHUS.Kh. М. Emirova, Е. S. Stolyarevich take part in educational events for doctors as lecturers with the support of Alexion Pharma. The other contributors confirmed the absence of a reportable conflict of interest.
Hybrid technology in the surgical treatment of proximal aortic dissection
Authors: Chernyavsky A. M. , Lyashenko M. M. , Syrota D. A. , Khvan D. S. , Kozlov B. N. , Panfilov D. S. , Lukinov V. L. 
Published: February 2019

Aim. To assess results of Meshalkin National Research Medical Center and Tomsk National Research Medical Center in surgical treatment of DeBakey type I aortic dissection using hybrid technologies (“frozen elephant trunk”) compared with classical standard interventions.Material and methods. The study included patients operated on successively in the 2002­2010 timeframe with a diagnosis of acute and subacute DeBakey type I aortic dissection. A retrospective observational comparison of the surgical treatment results of patients (two groups) was performed: using standard surgical approaches (beveled anastomosis or aortic arch replacement using multi­branched prosthesis) and frozen elephant trunk (FET) intervention. The groups included 70 and 31 patients, respectively. Mortality and morbidity were evaluated in the postoperative period, the frequency of aorto­related events — during the observation period.Results. Mortality and the frequency of complications between the groups in the early and late postoperative periods did not differ. Aorto­related events of the groups in the long­term period differed statistically significantly in favor of hybrid interventions (p=0,005).Conclusion. The hybrid technology of thoracic aorta reconstruction using “frozen elephant trunk” type allows to make one­step reconstruction of the aorta during its multilevel lesion. Observation of patients in the long­term period allows us to announce of a longtime, stable result of surgical treatment in the absence of additional perioperative risks.
New Frontier in Lipids: PCSK9 Inhibitors and Implications for the Life Insurance Industry
Authors: Tarpley Alacia J 
Published: February 2019

Since the Framingham Heart Study solidified cholesterol as a causative agent in the development of coronary heart disease there has been an explosion of research in the field of lipidology. Many therapeutic options have come and gone as we have been refining the goals of therapy to match the mortality outcome data of large clinical trials.
A new frontier has emerged with the introduction of the PCSK9 inhibitors that are able with monthly injections to lower LDL cholesterol &gt;60% with favorable side effect profiles and recently published favorable mortality data. This ushers in a whole new era of cholesterol management. Life insurance medical directors will need to be informed of how these drugs are being used and for conditions such as homozygous hypercholesterolemia, a condition with a very high mortality risk, and for new genetic analysis of affected patients, who are not as rare as once thought.
This article provides the background about the development of these drugs, their expanded indications, how they may slip through the cracks of prescription drug (Rx) database inquiries, and touches on therapies in development beyond this class of medications. Medicine is an evolving field. With the new gene editing CRISPR technology it will truly be transformational for these genetically driven conditions with the potential for curative therapy. If curative therapy comes to pass it will, of course, have favorable implications for our evolving life insurance guidelines.
Les philosophes à propos du mariage : un aspect de la pensée économique antique à l’époque classique
Authors: Helmer Étienne 
Published: February 2019

Quel regard les philosophes grecs classiques portaient-ils sur l’économie domestique, en particulier sur la relation conjugale au sein de l’oikos, dont elle était une dimension fondamentale ? L’objet de cet article est de comparer les passages des philosophes de la période classique – Platon, Xénophon et Aristote, mais aussi le Pseudo-Aristote – relevant d’une réflexion sur l’économie domestique, pour observer les déplacements et les recoupements auxquels ils se livrent sur ce thème. Si tous s’interrogent sur le principe moteur de l’union conjugale, sa nature et sa finalité, ils ne les envisagent pas de la même façon. Tous s’accordent néanmoins, avec des différences notables cependant, à voir dans cet aspect de l’économie domestique un processus de fabrique des corps des membres de la cité : au sein de l’économie domestique, le mariage est l’institution médiatrice entre le biologique et le politique.
Relación de hallazgos en citologías cérvico vaginales y colposcopias con infección por el virus del papiloma humano, en una población de la ciudad de Santa marta
Authors: Muñoz Zúñiga Cesar , Hernández  Aguirre Enio , Arrieta   De Castro Francisca 
Published: February 2019

Introducción: la citología cérvico vaginal es una prueba de tamizaje para detectar las neoplasias intracervicales (NIC), que ha disminuido la incidencia y la mortalidad por cáncer de cuello uterino (CCU). El diagnóstico del NIC es más frecuente entre los 20 y 30 años y el de CCU tiene una mayor frecuencia entre los 30 y 40 años. Desde 1983 a 1991 la tasa de mortalidad por CCU en Colombia fue de 6,5/100.000 habitantes y el 50% de estos casos murieron por diagnóstico tardío. Aunque se divulga que la infección por el papilomavirus es la causa necesaria, no es suficiente para el desarrollo del CCU. Objetivo: determinar una relación entre VPH y el desarrollo de NIC y CCU. Materiales y métodos: se revisaron 11.992 citologías vaginales en el período de un año, y a las VPH positivas por patología se les realizó biopsia de cérvix. Resultados: hay mayor probabilidad de adquirir VPH entre los 30 y 39 años, que se reduce en menores de 19 y mayores de 50 años. Con la sola presencia del virus la probabilidad de desarrollar NIC-I es de 5.8%, la de desarrollar NICII-III es de 0.29% y la de desarrollar CCU es de 0.08%. Conclusiones: se encontraron 9 casos de CCU en 735 citologías con VPH diagnosticadas por patología, que corresponde al 1.2%; y una probabilidad del 0.08% para el desarrollo del cáncer, teniendo en cuenta solo la presencia del VPH. Este resultado sugiere que se necesitan otros factores para el desarrollo del cáncer.
Age-related immune response to measles virus in staff of a large city hospital
Authors: Kostinov M. P. , Filatov N. N. , Zhuravlev P. I. , Gladkova L. S. , Polishchuk V. B. , Shmit’ko А. D. , Pakhomov D. V. , Khromova E. A. , Kostinova A. M. , Vasil’yeva G. V. , Tikhonova I. А. , Ryzhov A. A. , Blagovidov D. А. , Kostinov A. M. 
Published: February 2019

The aimsof the study were to examine age-related features of immune response to measles virus in staff of a large city hospital and to define groups at risk for measles outbreaks.Methods.The study involved 1,855 staff members of a large city hospital aged ≥ 19 years old who had documented vaccination against measles or a history of measles. The participants were divided into age groups with 5-year intervals starting from 19 years of age; there were 11 groups in total. The immune response to measles virus was measured in sera by ELISA using Vector-Best IgG-Kor test system (Russia).Results.Young employers of 19 to 23 years of age were most susceptible to measles; protective antibody level was not detected in 38.5% of them. They were followed by young-to-middle-aged workers (24 to 48 years old) who were negative for anti-measles antibodies or had non-protective level of antibodies in 16.7% to 27.5%. The anti-measles antibody level was low (42.3 % to 60.0 %) in employers of 19 to 43 years of age and gradually increased to 46.3% – 92.2% in the group of 44 to 68 years old.Conclusion.Herd immunity against measles in employers of a large city hospital did not meet requirements for successful infection control which implicates ≤ 7% of seronegative individuals. This means that measles outbreak could occur at any time because the proportion of seronegative individuals (11.5%) twice exceeded the cut-off value; the antibody level was controversial in 3.2% of individuals. Therefore, monitoring anti-measles antibody level in hospital staff is necessary to detect groups at risk who should be vaccinated against measles.
Implementation Research Methodologies for Achieving Scientific Equity and Health Equity
Authors: McNulty Moira , Smith J.D. , Villamar Juan , Burnett-Zeigler Inger , Vermeer Wouter , Benbow Nanette , Gallo Carlos , Wilensky Uri , Hjorth Arthur , Mustanski Brian , Schneider John , Brown C. Hendricks 
Published: February 2019

Implementation science has great potential to improve the health of communities and individuals who are not achieving health equity. However, implementation science can exacerbate health disparities if its use is biased toward entities that already have the highest capacities for delivering evidence-based interventions. In this article, we ex­amine several methodologic approaches for conducting implementation research to ad­vance equity both in our understanding of what historically disadvantaged populations would need—what we call scientific equi­ty—and how this knowledge can be applied to produce health equity. We focus on rapid ways to gain knowledge on how to engage, design research, act, share, and sustain successes in partnership with communities. We begin by describing a principle-driven partnership process between community members and implementation researchers to overcome disparities. We then review three innovative implementation method paradigms to improve scientific and health equity and provide examples of each. The first paradigm involves making efficient use of existing data by applying epidemiologic and simulation modeling to understand what drives disparities and how they can be overcome. The second paradigm involves designing new research studies that include, but do not focus exclusively on, popula­tions experiencing disparities in health domains such as cardiovascular disease and co-occurring mental health conditions. The third paradigm involves implementation research that focuses exclusively on popula­tions who have experienced high levels of disparities. To date, our scientific enterprise has invested disproportionately in research that fails to eliminate health disparities. The implementation research methods discussed here hold promise for overcoming barri­ers and achieving health equity.Ethn Dis. 2019;29(Suppl 1):83-92; doi:10.18865/ ed.29.S1.83.
Implementation Research Methodologies for Achieving Scientific Equity and Health Equity
Authors: McNulty Moira , Smith J.D. , Villamar Juan , Burnett-Zeigler Inger , Vermeer Wouter , Benbow Nanette , Gallo Carlos , Wilensky Uri , Hjorth Arthur , Mustanski Brian , Schneider John , Brown C. Hendricks 
Published: February 2019

Implementation science has great potential to improve the health of communities and individuals who are not achieving health equity. However, implementation science can exacerbate health disparities if its use is biased toward entities that already have the highest capacities for delivering evidence-based interventions. In this article, we ex­amine several methodologic approaches for conducting implementation research to ad­vance equity both in our understanding of what historically disadvantaged populations would need—what we call scientific equi­ty—and how this knowledge can be applied to produce health equity. We focus on rapid ways to gain knowledge on how to engage, design research, act, share, and sustain successes in partnership with communities. We begin by describing a principle-driven partnership process between community members and implementation researchers to overcome disparities. We then review three innovative implementation method paradigms to improve scientific and health equity and provide examples of each. The first paradigm involves making efficient use of existing data by applying epidemiologic and simulation modeling to understand what drives disparities and how they can be overcome. The second paradigm involves designing new research studies that include, but do not focus exclusively on, popula­tions experiencing disparities in health domains such as cardiovascular disease and co-occurring mental health conditions. The third paradigm involves implementation research that focuses exclusively on popula­tions who have experienced high levels of disparities. To date, our scientific enterprise has invested disproportionately in research that fails to eliminate health disparities. The implementation research methods discussed here hold promise for overcoming barri­ers and achieving health equity.Ethn Dis. 2019;29(Suppl 1):83-92; doi:10.18865/ed.29.S1.83.
Effect of Antihipertensive Drugs And Banana (Musa Sp.) To Potassium Serum Levels of Hypertensive Wistar Rats Model
Authors: Olivia Zora , Suryana Arinda Lironika 
Published: February 2019

Consumption of antihypertensive drugs has the potential to cause drug and food interactions. Captopril/lisinopril can increase potassium levels by inhibiting the activity of renin angiotensin aldosterone. If captopril/lisinopril is consumed together with bananas, there is a risk of hyperkalemia because bananas are a high pottasium fruits. The aimed of this study was to determined the effect of captopril/lisinopril given with banana (Musa Sp) on potassium serum levels of Rattus novergicus strain Wistar hypertension model. This research was an experimental study with a randomized post-test control group design.Thirty (30) male wistar strain rats aged 2-3 months, weighing 200-250 grams were divided into 6 groups. The control group (K-) non-hypertensive rats, the control group (K+) hypertension rats+standard diet, the treatment group (P1) hypertension rats + standard diet + captopril 2.25 mg/kgBB, the treatment group (P2) hypertensive rats + standard diet + lisinopril 0.6 mg/kgBB, treatment group (P3) hypertension rats + standard diet + captopril with banana and treatment group (P4) hypertension rats + standard diet + lisinopril with bananas. Measurement of potassium serum levels was carried out using electrolyte analyzer. Furthermore, the data were analyzed by One Way ANOVA test. The results showed that there were no significant differences in potassium serum levels between all groups. In conclusion, both of captopril 2.25 mg/kgBB and lisinopril 0.6 mg/kgBB given together with banana 9g/kgBB for 3 days hasn’t caused drug and food interactions.
Keywords: banana fruits, captopril, lisinopril, potassium serum
60 Yaş Üstü Sosyal Medya Kullanıcılarının Kullanıcı Arayüzü Deneyimlerinin İncelenmesine Yönelik Bir Araştırma Çalışması
Authors: BARANSELİ Ebru , KAYA Soner , ŞEN Mine 
Published: February 2019

İnternet teknolojilerinin gündelik hayatın vazgeçilmez bir parçası haline gelmesi, farklı özelliklerdeki kullanıcıların ihtiyaçlarına yönelik arayüz tasarım alternatiflerini gündeme getirmiştir.
Her yaş grubundan insanın kullanımına açık olan sosyal medyanın arayüz tasarımları için, farklı
yaş gruplarına yönelik farklı tasarım çözümlerine ihtiyaç duyulmaktadır. SnapChat gibi uygulamalarda olduğu gibi sadece arayüz tasarımı farklılaştırılarak belli yaş gruplarından oluşan hedef
kitleye ulaşmak mümkün olabilmektedir. Arayüz tasarımları özelleştirilerek sadece belli özellikteki insan topluluklarına hizmet verebilmektedir. Bu bağlamda farklı yaş gruplarının kullanıcı
arayüz tasarımları ile olan etkileşimleri, ihtiyaçları ve karşılaştıkları zorlukları belirlemek önem
kazanmıştır. Bu ihtiyaçların belirlenmesi adına, 60 yaş üstü sosyal medya kullanıcılarının demografik özelliklerinin, sosyal medya ve kullanıcı arayüz tasarımları ile ilgili tutumlarına yönelik bir
araştırma yapmak bu makalenin amacıdır. Araştırma sürecinde belirlenen hedef kitleden 137 sos-
yal medya kullanıcısına sosyal medya etkileşimleri ve ihtiyaçları ile ilgili sorular yöneltilmiş, çıkan
sonuçlar araştırmada yanıtları aranan 4 soru üzerinden yorumlanmıştır. Araştırmada öne çıkan
sonuçlardan biri, 60 yaş üstü kullanıcıların, sosyal medya sitelerini, bağlandıkları cihazlar üzerin-
den yakınlaştırmaya ihtiyaç duymalarıdır. Sosyal medya uygulamalarında arkaplan renklerinin
sadeliği, metinlerin daha büyük görünmeleri bu yaş grubu kullanıcılar için önemli kriterler olarak
değerlendirilmektedir. Bu araştırma sonucunda farklı yaş gruplarına yönelik arayüz tasarımları
ihtiyacı ve bu arayüzlerin kişiselleştirme özelliğine sahip olması gerekliliği ön plana çıkmıştır.&nbsp;