bluuebunny/crossref_metadata_2025_split huggingface dataset:
The AinS autoinducer synthase and LitR master regulator of quorum sensing regulate N-3-hydroxy-decanoyl-homoserine-lactone production and motility in Aliivibrio wodanis 06/09/139
Authors: Maharajan Amudha Deepalakshmi , Hansen Hilde , Willassen Nils Peder 
Published: July 2019

Abstract
Background
Quorum Sensing (QS) is a cell to cell communication system, in which bacteria synthesize and respond to signaling molecules called autoinducers (AI). QS is cell density dependent and known to be involved in regulating virulence, motility and secretion systems to interact with the host or other bacteria. Aliivibrio wodanis is frequently isolated together with Moritella viscosa from the infected Atlantic salmon during outbreaks of the winter ulcer disease. M. viscosa is the main causative agent of the disease while the presence of A. wodanis is still unclear. It is hypothesized that A. wodanis might influence the progression of winter ulcer. The genome of A. wodanis 06/09/139 encodes two autoinducer synthase genes (ainS and luxS) and a master regulator litR. LitR homologs in other aliivibrios have been shown to regulate several phenotypes in a cell density dependent manner. Moreover, a previous study has shown that A. wodanis 06/09/139 produces only one AHL N-3-hydroxy-decanoyl-homoserine-lactone (3OHC10-HSL). Hence, in this work, we have studied the QS system in A. wodanis 06/09/139 by knocking out QS genes ainS and litR. The effects of the deletions were studied with regard to growth, AHL production and motility at different temperatures.
Results
By using HPLC-MS/MS, we found that the deletion of ainS in A. wodanis 06/09/139 resulted in the loss of 3OHC10-HSL production. The 3OHC10-HSL production in A. wodanis 06/09/139 increased with increase in cell density and more 3OHC10-HSL was produced at 6°C than at 12, 16 and 20°C. The litR mutant demonstrated a ~20% reduction in the production of 3OHC10-HSL relative to the wild type at the stationary phase. Compared to the wildtype and the ainS mutant strains, the litR mutant resulted in a strain with improved temperature tolerance. The motility in mutants (∆litR and ∆ainS) were significantly higher than that of the wildtype.
Conclusions
Our study shows that AinS in A. wodanis 06/09/139 is the AHL synthase responsible for 3OHC10-HSL production, where the production is both cell density and temperature dependent. Our data also shows that LitR regulates 3OHC10-HSL production only to a minor extent and both LitR and AinS are negative regulators of motility.
Prepared for PrEP: Preferences for HIV pre-exposure prophylaxis among Chinese men who have sex with men from an online national survey
Authors: Huang Wenting , Wu Dan , Ong Jason O. , Smith M. Kumi , Yang Fan , Fu Hongyun , Tang Weiming , Tucker Joseph D. 
Published: July 2019

Abstract
Pre-exposure prophylaxis (PrEP) is not widely available in China. Previous studies reported low awareness and inconclusive findings on the acceptability of PrEP among Chinese men who have sex with men (MSM). We conducted a secondary analysis of an online national survey comparing the interests and preferences for oral and long-acting injectable PrEP among MSM and their correlates with HIV risk behaviors. Nine-hundred seventy-nine out of 1045 men responded to the PrEP survey questions. Most men had never heard of PrEP (81.9%) but reported interest in using PrEP. More participants chose injectable PrEP (36.3%) as their preferred formulation than oral PrEP (24.6%). Men who had at least two HIV tests (aOR = 1.36, 95%CI 1.04, 1.78) more commonly preferred injectable PrEP. Future PrEP promotion could be introduced along with HIV prevention and testing services through community activities.
Risk factors, antimicrobial susceptibility pattern and patient outcomes of Pseudomonas aeruginosa infection: A matched case-control study
Authors: Alhussain Fatima A , Eidan Fahad A Al , Johani Sameera Al , Badri Motasim 
Published: July 2019

Abstract
Background

Pseudomonas aeruginosa (P.aeruginosa) is a leading nosocomial gram-negative pathogen associated with prolonged hospitalization, morbidity and mortality. Limited data exist regarding P.aeruginosa infection and outcome in patients managed in intensive care units (ICUs). We aimed to determine the risk factors, antimicrobial susceptibility pattern and patient outcomes of P.aeruginosa infection.

Methods

In this matched case-control study, all P.aeruginosa infections that occurred >48 hours after hospital admission between January 31st 2016 and December 31st 2018 at ICUs affiliated with King Abdulaziz Medical City, Riyadh were included. P.aeruginosa bacilli was confirmed using API 20E test and antimicrobial susceptibility using disk diffusion or Epsilometer test.

Results

The study included 90 cases and 90 controls. Compared with controls, cases had significantly higher mean ICU stay days, proportions of patients with previous history of antimicrobial therapy, coronary artery disease, malignancy, hemodialysis, previous surgery, use of central line, urethral catheterization, nasogastric tube, and tracheostomy. In a multivariate conditional logistic regression analysis, factors independently associated with P.aeruginosa infection were ICU duration [Odds Ratio (OR)=9.05,95%CI 2.53-32.27, p=.001], previous surgery (OR=7.33,95%CI 1.66-32.36,p=.009), tracheostomy (OR=11.13,95%CI 1.05-118.59,p=.046), urethral catheterization (OR=7.38,95%CI 1.21-45.11,p=.030) and aminoglycoside drug class (OR=10.59,95%CI 1.14-98.13,p=.038). Of antimicrobial drugs used, highest proportion of resistance was calculated for patients receiving tigecycline (93.3%). Mortality was high in both groups but did not differ significantly: 54(60%) cases and 51(56.7%) controls; p=.650.

Conclusions:
The study identifies several modifiable factors associated with P.aeruginosa infection in ICUs. These factors are of paramount relevance for case identification, control measures, and optimal treatment strategies of P.aeruginosa infection in ICUs.
What do teachers and leaders have to say about co-teaching in flexible learning spaces?
Authors: Mackey Julie , O’Reilly Neill , Fletcher Jo , Jansen Chris 
Published: July 2019

Abstract
Schools in New Zealand and parts of Australia are rapidly transitioning from traditional classrooms to coteaching in flexible learning spaces provisioned for 50 to 180 children and two to six teachers in a single space. In New Zealand, this transition is driven by the Ministry of Education who have specific guidelines for designing new schools and re-builds. School leaders and teachers must reconceptualise teaching and learning from private autonomous learning environments to co-teaching in shared learning spaces.
This mixed methods study examined the views of 40 practitioners and leaders, experienced in coteaching contexts in New Zealand and Australian schools, to develop a greater understanding of the factors that contribute to effective co-teaching implementation. Not surprisingly, educators highlighted that shared beliefs about student centred pedagogy were pivotal to their co-teaching relationships. Beyond this central element, participants also identified a range of systems, tools, strategies and skills that enabled co-teaching to focus on and support student learning. The study provides insights of value to school leaders who are faced with the challenges of implementing flexible learning spaces, and leading school change in this area.
Widening the leadership story – moving beyond the individual
Authors: Baxendine Linda 
Published: July 2019

AbstractDistributed leadership that includes democratic practices can open spaces for children and their families to share their knowledge and skills and participate in everyday early childhood leadership activity. Drawing on the findings of a Masters thesis this article discusses how one kindergarten’s exploration of the local community has afforded insights into reframing leadership as an emerging social process whereby teachers, children and families are participants in an approach to leadership described as democratic leadership. Past leadership research has commonly focused on skills, traits and behaviours of people deemed leaders. Moving away from the primacy of the individual towards knowing leadership as an emergent phenomenon that exists between people incorporating multiple worldviews, elevates democratic principles such as collaboration and meaningful participation. Leadership-as-practice was used to analyse the ways in which excursions into the community have broadened teachers’ understandings of leadership and fostered more democratic and inclusive participation of children and families in the kindergarten programme. Utilising excursions within the local community as a mechanism to support a democratic form of leadership suggests that leadership can be perceived as arising from the collective work of people in everyday contexts. The value of extending the learning environment beyond the boundaries of the kindergarten, to engage with the local community, offers possibilities to make connections with the surrounding land, understand local stories, histories and cultural events. In this sense democratic leadership intersects with place-based education as children’s awareness of themselves as citizens of a community deepens. Inquiry as a form of participatory democracy was a key feature of decision-making in this study and provided a common purpose for community excursions while encouraging leadership opportunities.
Middle-level leaders as direct instructional leaders in New Zealand schools: A study of role expectations and performance confidence
Authors: Cardno Carol , Robson Joanne , Bassett Martin , Howse Jo 
Published: July 2019

Abstract
The literature on instructional leadership consistently assigns this role to school principals whilst indicating that it can be spread amongst others. Recently the spotlight has moved to middle leadership involving a focus on classrooms through direct instructional leadership. The purpose of this study was to add to a small but growing body of literature that centres on middle-level leadership in schools. The research aims were to conceptualise the nature of the direct form of instructional leadership that has been devolved to the middle leadership level; investigate perceptions of expectations held of middle leaders in schools; and investigate their perceived confidence in performing the role. An on-line survey of 185 primary and secondary school middle-level leaders confirmed strong agreement with the role expectations described in terms of a conceptual framework of direct instructional leadership. The results indicated that whilst overall confidence in performing these tasks was high, gaps existed between role expectations and performance confidence, with the function of “having difficult conversations” being the largest gap for both primary and secondary school middle-level leaders.
The Others in Charlotte Brontë’s Jane Eyre: A Postcolonial-Orientalist and Feminist Reading
Authors: BARIN AKMAN Filiz 
Published: July 2019

There are different forms of
othering in Charlotte Brontë’s Jane Eyre:&nbsp; one which results from Jane’s ambiguous
position in terms of class hierarchies and another generated by Bertha’s
presence as a colonized subject. In both cases, femininity amplifies gender-specific
repercussions in these othering processes. However, while Brontë creates a
female character in Jane who triumphs over the challenges posed by Victorian
society’s class and gender hierarchies, i.e., the status as other of
governesses and women, problematic as it is in its final solidification of the
status quo, Bertha reflects the dominant, Eurocentric ideologies of nineteenth
century England concerning race and the racial other. She is the colonized and
racial other, a madwoman who threatens British men as embodied in Mr.
Rochester, and women embodied as in Jane, and her final self-destruction for
Jane’s sake are poignant plot devices to this end.&nbsp; This paper offers a comparative reading of
two female characters’ othered status in Victorian British society in relation
to the dominant ideologies of the era concerning gender, class and race. I
argue that whereas Brontë, following a feminist reading of her novel, fictively
assuages the othered status of British women in the characterization of Jane,
who triumphs in resisting society’s rigid class boundaries and women’s
subordinate position in terms of legal and financial matters, does not grant a
similarly fictive emancipatory view to Bertha as the colonized and racial
other. This is an obvious and clear indication of Brontë’s limitations
concerning feminist activism and inclusiveness as her implication in advancing
the dominant, imperialist discourse.
Divan Şiirinde “Dedim-Dedi” Söyleyişi
Authors: TAŞKESENLİOĞLU Lokman 
Published: July 2019

Divan edebiyatı, başlangıcından 19. yüzyıla kadar oluşturduğu zengin edebî
gelenek ile gerek halk edebiyatının gerekse Tanzimat döneminden itibaren
yenileşme dönemi Türk edebiyatının şekillenmesine yardımcı olmuştur. Özellikle
halk edebiyatını nazım birimi, nazım şekilleri, mazmunlar ve ölçü gibi
hususlarda etkilemiş, pek çok halk şairi bu bakımdan divan edebiyatından
beslenmişlerdir. Bu etki ters istikamette de hâsıl olmuş, belli başlı
hususlarda divan şairleri de millî şiir geleneğinden etkilenmiş, halk
edebiyatının karakteristik özelliklerinden faydalanmışlardır. Bazı divan
şairlerinin hece ölçüsünü kullanmaları, türkü gibi nazım şekillerinin
örneklerini vermeleri, dilde sadeleşme temayülleri bu müşterek noktalar
arasında gösterilebilir. Klasik şairlerin halk şiirinden etkilenerek
eserlerinde kullandıkları bir diğer üslup özelliği de “dedim-dedi” veya
“mürâcaa” olarak ifade edilen söyleyiş tarzıdır. Erzurumlu Emrah, Âşık Ömer,
Gevheri gibi pek çok halk âşığının sevgili ile karşılıklı konuşuluyormuş
edasıyla söyledikleri şiirler ile geleneğe kattıkları bu samimi söyleyişin
örneklerini divan edebiyatında da görmek mümkündür. Bu söyleyiş bazen
beyitlerde sınırlı kalmış, bazen de tıpkı halk şiiri örneklerinde olduğu gibi
şiirin tamamına hâkim olmuştur. Fuzûlî, Ahmedî, Şeyhî, Muhibbî gibi pek çok
önemli divan şairinin dahi şiirlerinde bu söyleyişe yer vermeleri, divan ve
halk edebiyatları arasındaki çizginin çok da keskin olmadığını, divan
şairlerinin halktan ve halk şiirinden kopuk bir şiir anlayışı
geliştirmediklerini göstermektedir. Bu çalışmada halk şiiri üslup
özelliklerinden olan “dedim-dedi” söyleyiş tarzının divan edebiyatındaki
yansıması ele alınmıştır. Halk edebiyatından örneklerle birlikte mürâcaa
söyleyişi hakkında verilen genel bilginin akabinde beyit ve şiir bütünlüğü
çerçevesinde bu söyleyiş özelliği taşıyan metinler verilmiş, bu şekilde
“dedim-dedi” tarzının divan edebiyatındaki örnekleri derlenmiştir.
Liedtexte Der 90er Jahre Mit Migrationshintergrund
Authors: BALCI Umut 
Published: July 2019

Die Musik hat dank ihrer
spezifischen, autonomen und wirksamen Sprache eine kommunikative Dimension, die
die Menschen aus verschiedenen Kulturen einander näherbringt und die
Integration in andere Gesellschaften erleichtert. Musik der türkischen
Migranten in Deutschland ist in dem Sinne von großer Relevanz, dass türkische
Migranten ab 60er Jahren mit den Deutschen bzw. mit einer fremden Kultur
konfrontiert sind. Davon ausgehend haben wir in dieser Arbeit darauf
konzentriert, zuerst die Entstehungs- und Entwicklungsprozess der türkischen
Migrantenmusik chronologisch in die Hand zu nehmen, danach die Liedtexte der
90er Jahre nach hermeneutischer Methode inhaltlich zu analysieren. Ziel unserer
Arbeit ist es, musikalische Bewegungen türkischer
Migranten in Deutschland bekannt zu machen und somit festzustellen, in welche
Richtung und aus welchen Gründen die Migrantenmusik der 90er Jahre thematisch
entwickelt hat.
Bozüyük Kasım Paşa Camii Süsleme Programı
Authors: Bilir Timur 
Published: July 2019

Günümüzde Bilecik’e bağlı bir sanayi kenti
olan Bozüyük, Osmanlı İmparatorluğu’nun kuruluşundan milli mücadele yıllarına
kadar önemli bir tarihi geçmişe sahiptir. Demiryolu hattının açılmasına kadar
kara yolu güzergâhında bulunan ilçe, Osmanlının doğu seferlerine çıkarken
konaklama noktası olarak kullandığı bir merkez konumundaydı. 16. yüzyılın ilk yarısında Kasım
Paşa tarafından buraya yaptırılan külliye, günümüzdeki Bozüyük şehrinin varlık
sebebi olmuştur. Külliyeden günümüze orijinalliğini koruyarak gelen tek yapı
cami kısmıdır. Dışardan sade bir mimarisi olan caminin içinde zengin bir
süsleme programı bulunmaktadır. Bu
makalede, caminin süslemeleri detaylı bir şekilde ele alınarak süslemelerle
ilgili çizim ve fotoğraflara yer verilmiştir.
Manoglanistara - Emotional Wellness Phases Prediction of Adolescent Female Students by using Brain Waves
Authors: Mallikarjun H.M. , Manimegalai P. 
Published: July 2019

Background:
Depression is the most underestimated and widespread health condition
among people in developing countries. Depression levels among Indian population are rapidly increasing.
It can be attributed to work pressure, social challenges, addiction to social media, adoption
of the western culture and several other reasons. Indians’ depression levels are as high as 36
percent and shockingly this number is the highest in the world.

Objective:
What makes this even more alarming is the fact that WHO projects depression to be the
second leading cause of disability worldwide by2020.

Materials and Methods:
This work focuses on Machine learning based Depression prediction by
utilizing different brain wave frequency bands. It is carried out by askingthe universal standard
Patient Health Questionnaire (PHQ.9) to subjects which are related to respective emotions. Neurosky’s
Mind Wave Head kit is connected to the forehead (of subject) and 86 sample values are
recorded. Total 85 Samples are trained, whereas 1 data is tested.

Results:
The MANOGLANISTARA- android App has been designed which sends the Emotional
Wellness output (depressed/normal) to the subject via email. This provides the basis of analysis as
to whether the subject is suffering from depression or not. Customization of the medication and
treatment to such subjects can be initiated by the doctors.
In this work, the MATLAB SVM based Depression prediction model is developed by evaluating
the data built from Mindwave kit and standard PHQ.9 questionnaire. Work is also extended by using
Orange Toolbox for classification of depressed/ normal subjects.

Conclusion:
In Orange toolbox, Prediction, ROC Analysis and Confusion Matrix are evaluated
for different classifiers such as SVM, Naïve Bayes, Classification tree, Random forest and CN2
Rule Inducer. Accuracy, Precision, Sensitivity and Specificity is computed for all the abovementioned
classifiers. CN2 Rule Inducer classifier gave higher accuracy of 0.9418, sensitivity
0.9778, Specificity 0.9736 and Precision 0.9778.
Implications of Vitamin D in Multiple Sclerosis and Other Neurodegenerative Processes: Bibliometric Analysis and Systematic Review
Authors: Caballero-Villarraso Javier , Jiménez-Jiménez María J. , Escribano Begoña M. , Agüera Eduardo , Santamaría Abel , Túnez Isaac 
Published: July 2019

:In recent years, numerous investigations focused on the pleiotropic actions of vitamin D have been carried out. These actions include the participation of this molecule in neurophysiological and neuropathological processes. As a consequence, abundant scientific literature on the role of this vitamin in neurodegenerative entities has emerged, even concerning clinical studies. To identify the level of scientific evidence concerning the relation between vitamin D and neurodegenerative diseases, from a quantitative and qualitative perspective. To describe, by means of a bibliometric analysis, the scientific production and its evolution through time in quantitative terms, regarding the implications of vitamin D in neurodegeneration. To analyse and present the degree of evidence in the aforementioned field of study, a systematic review of the literature focused on the most prevalent neurodegenerative diseases was carried out. We retrieved 848 articles in the bibliometric analysis, the majority of which were dated between the years 2010-2017. The most studied metabolite was the 25(OH)D3 and the most cited disease was multiple sclerosis. In the systematic review, we found studies about Alzheimer’s and Parkinson’s diseases and again, about multiple sclerosis prominently (in number and quality), with 12 randomised double-blind clinical trials. The research about vitamin D and its relations with neurodegenerative diseases shows a growing evolution over the last decade. More studies are needed to find correlations between the clinical severity of these diseases and the specific status of vitamin D and the genotypes related with them, which seems to be a future trend.
Minat siswa sekolah menengah pertama terhadap pembelajaran atletik
Authors: Utami Maratona Sakti , Purnomo Eddy 
Published: July 2019

Penelitian ini dilatarbelakangi oleh belum maksimalnya pembelajaran pendidikan jasmani pada materi atletik dan belum diketahuinya minat siswa terhadap pembelajaran atletik. Penelitian ini bertujuan untuk mengetahui minat siswa kelas VIII SMP Negeri 2 Jenawi Kabupaten Karanganyar dalam mengikuti pembelajaran atletik. Penelitian ini merupakan penelitian dekriptif kuantitatif. Metode yang digunakan adalah metode survei dengan teknik pengumpulan data menggunakan angket. Subjek penelitian ini adalah seluruh siswa kelas VIII kecuali kelas VIII C karena dijadikan sebagai uji coba penelitian, dari 4 kelas dipilih 25 siswa dengan cara diundi, sehingga mendapatkan populasi sebanyak 100 siswa. Teknik analisis yang dilakukan adalah menuangkan frekuensi ke dalam bentuk persentase. Hasil penelitian ini menunjukkan bahwa minat siswa SMP Negeri 2 Jenawi Kabupaten Karanganyar kelas VIII terhadap pembelajaran atletik adalah cukup. Dengan pertimbangan frekuensi terbanyak berada pada kategori sedang dengan persentase 83,00%. Persentase minat siswa SMP Negeri 2 Jenawi Kabupaten Karanganyar kelas VIII terhadap pembelajaran atletik yang berkategori sangat tinggi adalah 0,00%, tinggi 11,00%, sedang 83,00%, kurang 6,00% dan sangat kurang 0,00%. Interest of students of class VIII junior high school on athletic learning Abstract.The background problem of this research because not maximal yet in physical education learning on athletic material and the students' interest in athletic learning was unknown yet. This research aimed to know the students’ interest in athletic learning at the eighth-grade students of SMP 2 Jenawi Karanganyar regency. This research was quantitative descriptive research. The method used in this research was survey method while the technique of collecting the data used questionnaire. The research subject was the whole of eighth-grade students except VIII C class because it was used as a research trial, from four classes was chosen 25 students randomly, it got a population of 100 students. The technique of analyzing the data used the frequency in the form of the percentage. The result of the research showed that students’ interest in athletic learning at the eighth-grade students of SMP Negeri 2 Jenawi Karanganyar regency was enough. With consideration of the most frequency was enough with the percentage 83%. The percentage of students’ interest in athletic learning at the eighth-grade students of SMP Negeri 2 Jenawi Karanganyar regency who had the highest category was 0,00%, high 11,00%, enough 83%, low 6,00% and the lowest was 0,00%.