bluuebunny/crossref_metadata_2025_split huggingface dataset:
Estimation of Brain Age Delta from Brain Imaging
Authors: Smith Stephen M. , Vidaurre Diego , Alfaro-Almagro Fidel , Nichols Thomas E. , Miller Karla L. 
Published: February 2019

AbstractIt is of increasing interest to study “brain age” - the apparent age of a subject, as inferred from brain imaging data. The difference between brain age and actual age (the “delta”) is typically computed, reflecting deviation from the population norm. This therefore may reflect accelerated aging (positive delta) or resilience (negative delta) and has been found to be a useful correlate with factors such as disease and cognitive decline. However, although there has been a range of methods proposed for estimating brain age, there has been little study of the optimal ways of computing the delta. In this technical note we describe problems with the most common current approach, and present potential improvements. We evaluate different estimation methods on simulated and real data. We also find the strongest correlations of corrected brain age delta with 5,792 non-imaging variables (non-brain physical measures, life-factor measures, cognitive test scores, etc.), and also with 2,641 multimodal brain imaging-derived phenotypes, with data from 19,000 participants in UK Biobank.
DrugComb - an integrative cancer drug combination data portal
Authors: Zagidullin Bulat , Aldahdooh Jehad , Zheng Shuyu , Wang Wenyu , Wang Yinyin , Saad Joseph , Malyutina Alina , Pessia Alberto , Tang Jing 
Published: February 2019

ABSTRACTDrug combination therapy has the potential to enhance efficacy, reduce dose-dependent toxicity and prevent the emergence of drug resistance. However, discovery of synergistic and effective drug combinations has been a laborious and often serendipitous process. In recent years, identification of combination therapies has been accelerated due to the advances in high-throughput drug screening, but informatics approaches for systems-level data management and analysis are needed. To contribute toward this goal, we created an open-access data portal (https://drugcomb.fimm.fi) where the results of drug combination screening studies are accumulated, standardized and harmonized. Through the data portal, we provided the web server to analyze and visualize users’ own drug combination screening data. The users have an option to upload their data to DrugComb, as part of a crowdsourcing data curation effort. To initiate the data repository, we collected 437,932 drug combinations tested on a variety of cancer cell lines. We showed that linear regression approaches, when considering chemical fingerprints as predictors, have the potential to achieve high accuracy of predicting the sensitivity and synergy of drug combinations. All the data and informatics tools are freely available in DrugComb to enable a more efficient utilization of data resources for future drug combination discovery.
Emergence ofβandγnetworks following multisensory training
Authors: Rocca Daria La , Ciuciu Philippe , Engemann Denis Alexander , Wassenhove Virginie van 
Published: February 2019

AbstractOur perceptual reality relies on inferences about the causal structure of the world given by multiple sensory inputs. In ecological settings, multisensory events that cohere in time and space benefit inferential processes: hearing and seeing a speaker enhances speech comprehension, and the acoustic changes of flapping wings naturally pace the motion of a flock of birds. Here, we asked how a few minutes of (multi)sensory training could shape cortical interactions in a subsequent perceptual task, and investigated oscillatory activity and functional connectivity as a function of sensory history in training. Human participants performed a visual motion coherence discrimination task while being recorded with magnetoencephalography (MEG). Three groups of participants performed the same task with visual stimuli only, while listening to acoustic textures temporally comodulated with the strength of visual motion coherence, or with auditory noise uncorrelated with visual motion. The functional connectivity patterns before and after training were contrasted to resting-state networks to assess the variability of common task-relevant networks, and the emergence of new functional inter-actions following training. One main finding is the emergence of a large-scale synchronization in the highγ(gamma: 60−120Hz) andβ(beta:15−30Hz) bands for individuals who underwent comodulated multisensory training. The post-training network involved prefrontal, parietal, and visual cortices. Our results suggest that the integration of evidence and decision-making strategies become more efficient following congruent multisensory training through plasticity in network routing and oscillatory regimes.
R-DECO: An open-source Matlab based graphical user interface for the detection and correction of R-peaks
Authors: Moeyersons Jonathan , Amoni Matthew , Huffel Sabine Van , Willems Rik , Varon Carolina 
Published: February 2019

AbstractMany of the existing ECG toolboxes focus on the derivation of heart rate variability features from RR-intervals. By doing so, they assume correct detection of the QRS-complexes. However, it is highly likely that not all detections are correct. Therefore, it is recommended to visualize the actual R-peak positions in the ECG signal and allow manual adaptations.In this paper we present R-DECO, an easy-to-use graphical user interface for the detection and correction of R-peaks. Within R-DECO, the R-peaks are detected by an adaptation of the Pan-Tompkins algorithm. Instead of using all the pre-processing steps of the latter algorithm, the proposed algorithm uses only an envelope-based procedure to flatten the ECG and enhance the QRS-complexes. The algorithm obtained an overall sensitivity of 99.60% and PPV of 99.69% on the MIT/BIH arrhythmia database.Additionally, R-DECO includes support for several input data formats for ECG signals, three basic filters, the possibility to load other R-peak locations and intuitive methods to correct ectopic, wrong, or missed heartbeats. All functionalities can be accessed via the graphical user interface and the analysis results can be exported as Matlab or Excel files. The software is publicly available.Through its easy-to-use-graphical user interface, R-DECO allows both clinicians and researchers to use all functionalities, without previous knowledge.
Development and validation of microsatellite markers fromde novotranscriptome assembly of eggplant (Solanum melongenaL.) and its putative progenitorS. incanumL. cultivars
Authors: Tiwari Shailesh K. , Mishra Pallavi , Singh Sakshi , Singh Vinay K , Kashyap Sarvesh P , Singh Major , Tiwari Kavindra N , Naik Prakash S , Singh Bijendra 
Published: February 2019

AbstractAn elite cultivar of eggplant, Ramnagar Giant (Solanum melongenaL.) and W-4 (S. incanumL.) with contrasting horticultural traits were used as parental lines to develop a mapping population of RILs. To accelerate breeding programs and to develop large scale SSR markers to be used in QTL mapping, RNASeqlibraries from different tissues of both the parental plants were deep sequenced and assembled into representation of a high qualityde novotranscriptome using Illumina-based Next Generation Sequencing technology. 99.99% of high quality bases were obtained from all the tissues and deposited in TSA database at the NCBI link. Total 3, 156 and 3, 196 SNVs were detected inS. melongenaandS. incanum, respectively. InS. melongena, 11, 262 SSR while inS. incanum11, 829 SSR containing regions were identified. Based on functional annotation, 21, 914 unique genes could be identified forS. melongena, 21,706 unique genes forS. incanumand overall, 60 different transcription factors were identified in both the lines. Further, a total of 536 SSR markers were designed and screened for polymorphism of which, 157 markers produced polymorphism between the parental lines. The polymorphic SSRs shall be used for genotyping of RILs to map QTLs for various horticultural traits in eggplant and identification of candidate genes in response to biotic and abiotic stress.
The effects of combining focus of attention and autonomy support on shot accuracy in the penalty kick
Authors: Makaruk Hubert , Porter Jared M. , Sadowski Jerzy , Bodasińska Anna , Zieliński Janusz , Niźnikowski Tomasz , Mastalerz Andrzej 
Published: February 2019

AbstractThe penalty kick is of great importance in the sport of soccer. Therefore, the aim of this study was to test predictions of the OPTIMAL theory and identify key attentional and motivational factors that impact the accuracy of the penalty kick. The following six groups of skilled participants performed penalty kicks following instructions that directed their focus of attention or impacted their autonomy support: external focus with autonomy support (EF/AS), external focus alone (EF), internal focus with autonomy support (IF/AS), internal focus alone (IF), autonomy support alone (AS) and control (C) groups. The analysis showed that the EF/AS group demonstrated better kicking accuracy relatively to the IF/AS, IF and C groups, but there were no significant differences between the EF/AS and EF or AS groups. Interestingly, the EF/AS group showed higher self-efficacy compared to the EF, IF/AS, IF and C groups. The finding suggest that a combination of attentional and motivational factors may produce benefits in motor performance.
Cooperative game-based profit allocation for joint distribution alliance under online shopping environment
Authors: Li Longxiao , Wang Xu , Lin Yun , Zhou Fuli , Chen Shan 
Published: February 2019

PurposeIn the context of sharing economy and online shopping, establishing a stable urban joint distribution alliance (JDA) is extremely necessary for the entire logistics service market. The purpose of this paper is to rationally allocate the profits and determine the most stable allocation scheme for the urban JDA as well as provide a direction for cooperation between express enterprises and lead managers to pay more attention to the comprehensive performance.Design/methodology/approachCooperative game-based methodologies including the proportion method, the core theory, nucleolus and Shapley value have been employed. Four criteria consisting of enterprise operation, customer satisfaction, environmental sustainability and information technology have been incorporated into Shapley value for improvement.FindingsThis paper reveals that express enterprises in logistics service market can achieve more benefit from JDA than those who operate separately. Among proposed profit allocation schemes, improved Shapley value scheme shows more rationality by considering partners’ asymmetric contribution. Besides, a stable alliance can be always ensured with partners’ lower propensity to disrupt and relatively balanced negotiation power under improved Shapley value scheme.Originality/valueThis paper makes a few attempts to contribute to the literature on the improvement of Shapley value and applies the concept of “propensity to disrupt” into the field of logistics. Besides, this paper provides various profit allocation schemes and incorporates influencing factors into Shapley value for an improvement thus helping policy-makers make better-informed decisions on urban distribution. Additionally, a case study based on urban express enterprises in Southwest China has been conducted to verify the proposed profit allocation schemes.
Heterogeneity in a dual personal values–dual purchase consequences–green consumption commitment framework
Authors: Le Angelina Nhat Hanh , Tran Mai Dong , Nguyen Dong Phong , Cheng Julian Ming Sung 
Published: February 2019

PurposeThe purpose of this paper is to study the roles of dual personal values (individualistic and collectivistic) and consumer attitudes toward dual purchase consequences (individual and environmental) as the precursors of a commitment to green consumption. Furthermore, the variance within the studied relationships is explored across the segments of the selected consumer sample.Design/methodology/approachPartial least squares and finite mixture–partial least squares path modeling approaches are employed to examine the studied relationships and check for heterogeneity, respectively, among the sample of 406 Vietnamese consumers.FindingsThe results indicate that individualistic values positively and negatively affect attitudes toward purchase consequences at the individual and environmental levels, respectively, while collectivistic values have only a positive impact on attitudes at the environment level. Compared to the individual level, attitudes toward environmental purchase consequences propagate a fuller commitment to green consumption. Collectivistic, but not individualistic, consumers are a suitable target segment for green business. Consumers within the selected sample exhibit different green behavioral patterns.Originality/valueThis research provides valuable insights into the under-researched aspect of green consumption commitment based on an extended value–attitude–behavior model. Previously unobserved heterogeneity is revealed and green consumption tendency segments are identified.
Family ownership and earnings quality of Thai firms
Authors: Boonlert-U-Thai Kriengkrai , Sen Pradyot K. 
Published: February 2019

Purpose
The purpose of this paper is to provide evidence that the quality of earnings of family run firms is superior to that of the other firms and that firms run by founding family members exhibit this trait even more prominently. Using insights from the fundamental accounting valuation model, this study also hypothesizes that financial markets place a higher weightage on earnings than book value for founding family-run firms in Thailand as these firms report a more reliable earnings number.

Design/methodology/approach
This is an empirical archival research.

Findings
The authors report evidence that financial markets place a higher weightage on earnings than book value for founding family-run firms. The evidence is consistent with the insight that current earnings of the founding family-run firms offer more information about future earnings and cash flow compared to book value than those for family (FAM) and non-family (NonCS) firms. The authors also provide evidence that earnings persistence and the accrual quality of the founding family firms are higher compared to the other firms. This evidence is contrary to the notion that family firms have more opaque disclosures, lower earnings quality and higher implied cost of equity capital.

Research limitations/implications
The authors find support for the alignment hypothesis of the long-term family ownership of Thai firms. The authors consider these evidences consistent with the shareholder interest alignment hypothesis of the controlling shareholders as opposed to the entrenchment hypothesis.

Practical implications
The study implies that earnings of the Thai firms run by founding family members are more reliable and can be relied on more for firm valuation. Additionally, the authors also offer a different methodology by appealing to the valuation properties of the reported accounting numbers besides looking at the quality of accruals and earnings persistence tests offered in the existing literature.

Social implications
The society is better off if there are more opportunities to invest in Thai firms run by founding family members. The finding of the quality difference in governance by firms with founding family members is new. Therefore, the study points to the need of finer partition of the family firms while looking at their corporate governance practices. The fact that the FF firms offer a higher quality of earnings implies that they are less engaged in opportunistic manipulation of earnings and cash flow and, thus, are self-motivated to protect the longer term interest of the firms.

Originality/value
This if the first time the accounting fundamental valuation theory has been used to provide evidence of higher earnings quality.
Hallowed be thy brand: measuring perceived brand sacredness
Authors: Wang Cheng Lu , Sarkar Juhi Gahlot , Sarkar Abhigyan 
Published: February 2019

PurposeThe purpose of this study is to capture the strength of consumer’s perceived brand sacredness. The authors developed and validated a measurement scale composed of three related dimensions: supremacy, mesmerization and communitas.Design/methodology/approachSix empirical studies were conducted to identify the brand sacredness construct domains, develop and validate the measurement and test the nomological network between brand sacredness and it antecedent and outcome variables.FindingsResults from a series of studies provided robust supports for the scale structure and demarcated the construct domains from other consumer–brand relationship measures. Testing of nomological validity of the scale further showed that brand sacredness is influenced by brand love, emotional brand attachment and brand loyalty and, meanwhile, provides explanatory power to predict theoretically related outcome variables, including transcendent consumer experience, defense of brand, incorporation brand in extended-self, brand ritualism and brand evangelism.Research limitations/implicationsThis study is based on cross-sectional survey data obtained from respondents belonging to well-established brand communities. A longitudinal study involving recent and emerging brand communities could provide an enhanced understanding of the evolution of brand sacredness with time, including brand sacralizaton process as well as possible de-sacralization process.Practical implicationsThe study provides significant insights for brand managers to create an enduring brand and ascertain that consumers find their affiliations with the brand and make it the sacred core of their lives by fandom management through brand evangelism.Originality/valueThis study adds to the theory on consumer–brand relationship realm by delineating the domains of brand sacredness with its defining feature of extraordinary experience transcending an ordinary brand. It contributes to the existing body of branding and customer-based brand equity literature by incorporating the spiritual aspects of faith, passion and devotion into measuring the value of a brand.
Entrepreneurial competences in a higher education business plan course
Authors: Ferreras-Garcia Raquel , Hernández-Lara Ana Beatriz , Serradell-López Enric 
Published: February 2019

Purpose
The purpose of this paper is twofold: first, to study which perceived and attained entrepreneurial competences acquired by students while developing a business plan are rated most highly; and second, to analyse the differences observed in entrepreneurial competences, depending on whether the business plan developed is real or fictitious.

Design/methodology/approach
To analyse the role played by business plans in perceptions and attainment of competence, data were collected from students enrolled on a final project course of a bachelor’s degree, specifically the Bachelor’s Degree in Business Administration and Management at the Universitat Oberta de Catalunya. The course in question focussed on entrepreneurship and business plans. The data on perceived and attained competences were obtained through questionnaires and assessment rubrics, respectively. Mean comparison analyses were conducted to investigate any differences in entrepreneurial competences existing between students developing real or fictitious business plans.

Findings
The paper finds evidence that the process of creating a business plan results in entrepreneurial competence being highly rated and that whether the business plan is real or fictitious does not affect the level of entrepreneurial competence.

Research limitations/implications
A longitudinal study will be required to analyse how entrepreneurial competences evolve during the business plan creation process.

Originality/value
This paper finds that few studies have been conducted to explore entrepreneurial competences in relation to business plan development and shows that more complete research is required. Moreover, both perceived and achieved competences are considered, an analysis not previously carried out.
Does IS0 9001 quality management system support product innovation? An analysis from the sociotechnical systems theory
Authors: El Manzani Younès , Sidmou Mohamed Larbi , Cegarra Jean-jack 
Published: February 2019

PurposeBuilding on the sociotechnical systems theory (STS), the purpose of this paper is to investigate the direct impacts of the social and technical QMs (ISO 9001) practices on both incremental and radical product innovation and the direct relationships relaying QMs (ISO 9001) as a sociotechnical system with incremental and radical product innovation.Design/methodology/approachThe paper opted for a survey instrument to collect quantitative data from 82 Moroccan certified ISO 9001 firm. A partial least squares structural equation modeling (PLS-SEM) was used to test the research hypotheses.FindingsResults show that the social and technical QMs (ISO 9001) practices do not have a significant relationship with incremental and radical product innovation when they are taken in isolation. However, when ranged together to constitute a whole sociotechnical system of QMs (ISO 9001), QMs (ISO 9001) prove to have a strong positive and significant impact on incremental product innovation and a weak positive and significant impact on radical product innovation.Research limitations/implicationsBecause of the small sample size that might weaken the significance of the results and the use of cross-sectional data, this research may lack a large statistical generalizabilityvis-à-visthe analytical generalization.Practical implicationsThe results provide useful implications for managers, suggesting that in order to develop their product innovation, they must ensure that both QMs (ISO 9001) social and technical practices achieve a high level of integration without allowing some quality practices to take over.Originality/valueBased on the STS, this study is the first to focus primarily on the role of the multi-dimensional structure of QMs (ISO 9001), i.e. social and technical practices, in incremental and radical product innovation.