bluuebunny/crossref_metadata_2025_split huggingface dataset:
Finger length ratio in longevity populations
Authors: Kalichman Leonid , Batsevich Valery , Kobyliansky Eugene 
Published: October 2019

AbstractObjectivesThe purpose of this study was to compare the prevalence of finger length ratio between three longevity populations (Abkhazians, Azerbaijanis, and Georgians) and one nonlongevity population (Russians), as well as between a longevity and nonlongevity sample within one ethnic group (Abkhazians).MethodsIn a cross‐sectional observational study, we compared the prevalence of finger length ratio in longevity vs nonlongevity samples.ResultsA negative relationship was observed between longevity index and prevalence of type 1 (feminine type) ratio. In longevity samples, the prevalence of type 1 ratio was lower and the prevalence of type 3 (masculine type) ratio was higher than in the nonlongevity sample of Russians. This difference was statistically significant (P < .001) in both males and females. A similar difference between longevity and nonlongevity samples was exhibited in the Abkhazian samples. In males and females, a significantly higher prevalence of type 1 and lower type 3 finger ratios (P < .001) were shown in the nonlongevity samples.ConclusionsFinger length ratio pattern in longevity populations differs from that of nonlongevity populations. In longevity samples, the prevalence of type 1 ratio was lower and the prevalence of type 3 ratio was higher vs the nonlongevity sample. A similar type of difference was seen in the longevity and nonlongevity samples belonging to one ethnic group, the Abkhazians. Previous studies found that the type 1 finger length ratio was related to important morbidities that have a potential for shortening the life span. This can be one of the most plausible explanations for our findings.
Design Parameters of Tissue‐Engineering Scaffolds at the Atomic Scale
Authors: Jekhmane Shehrazade , Prachar Marek , Pugliese Raffaele , Fontana Federico , Medeiros‐Silva João , Gelain Fabrizio , Weingarth Markus 
Published: October 2019

AbstractStem‐cell behavior is regulated by the material properties of the surrounding extracellular matrix, which has important implications for the design of tissue‐engineering scaffolds. However, our understanding of the material properties of stem‐cell scaffolds is limited to nanoscopic‐to‐macroscopic length scales. Herein, a solid‐state NMR approach is presented that provides atomic‐scale information on complex stem‐cell substrates at near physiological conditions and at natural isotope abundance. Using self‐assembled peptidic scaffolds designed for nervous‐tissue regeneration, we show at atomic scale how scaffold‐assembly degree, mechanics, and homogeneity correlate with favorable stem cell behavior. Integration of solid‐state NMR data with molecular dynamics simulations reveals a highly ordered fibrillar structure as the most favorable stem‐cell scaffold. This could improve the design of tissue‐engineering scaffolds and other self‐assembled biomaterials.
ZIF‐8 Membrane Separation Performance Tuning by Vapor Phase Ligand Treatment
Authors: Eum Kiwon , Hayashi Mikio , De Mello Matheus Dorneles , Xue Feng , Kwon Hyuk Taek , Tsapatsis Michael 
Published: October 2019

AbstractVapor phase ligand treatment (VPLT) of 2‐aminobenzimidazole (2abIm) for 2‐methylimidazole (2mIm) in ZIF‐8 membranes prepared by two different methods (LIPS: ligand induced permselectivation and RTD: rapid thermal deposition) results in a notable shift of the molecular level cut‐off to smaller molecules establishing selectivity improvements from ca. 1.8 to 5 for O2/N2; 2.2 to 32 for CO2/CH4; 2.4 to 24 for CO2/N2; 4.8 to 140 for H2/CH4 and 5.2 to 126 for H2/N2. Stable (based on a one‐week test) oxygen‐selective air separation performance at ambient temperature, 7 bar(a) feed, and 1 bar(a) sweep‐free permeate with a mixture separation factor of 4.5 and oxygen flux of 2.6×10−3 mol m−2 s−1 is established. LIPS and RTD membranes exhibit fast and gradual evolution upon a 2abIm‐VPLT, respectively, reflecting differences in their thickness and microstructure. Functional reversibility is demonstrated by showing that the original permeation properties of the VPLT‐LIPS membranes can be recovered upon 2mIm‐VPLT.
Radical Monofluoroalkylative Alkynylation of Olefins by a Docking–Migration Strategy
Authors: Wang Min , Zhang Huihui , Liu Jige , Wu Xinxin , Zhu Chen 
Published: October 2019

AbstractA radical‐mediated monofluoroalkylative alkynylation of alkenes is disclosed for the first time. The reaction demonstrates a remarkably broad substrate scope in which both activated and unactivated alkenes are suitable starting materials. The concurrent addition of an alkynyl and a monofluoroalkyl group onto an alkene proceeds through a docking–migration sequence, affording a vast array of valuable fluoroalkyl‐substituted alkynes. Many complex natural products and drug derivatives are readily functionalized, demonstrating that this method can be used for late‐stage alkynylation.
Aluminium‐Mediated Carbon Dioxide Reduction by an Isolated Monoalumoxane Anion
Authors: Anker Mathew D. , Coles Martyn P. 
Published: October 2019

AbstractThe deoxygenative conversion of carbon dioxide to carbon monoxide is promoted by the aluminyl anion [Al(NONAr)]−(NONAr=[O(SiMe2NAr)2]2−, Ar=2,6‐iPr2C6H3). The reaction proceeds via the isolable monoalumoxane anion [Al(NONAr)(O)]−, containing a terminal aluminum‐oxygen bond. This species reacts with a second equivalent of carbon dioxide to afford the carbonate [Al(NONAr)(CO3)]−, and with nitrous oxide to generate the hyponitrite anion, [Al(NONAr)(κ2O,O′‐N2O2)]−.
Giant Enhancement of Second Harmonic Generation Accompanied by the Structural Transformation of 7‐Fold to 8‐Fold Interpenetrated Metal–Organic Frameworks (MOFs)
Authors: Chen Zhihui , Gallo Gianpiero , Sawant Vaishali A. , Zhang Tianxiang , Zhu Menglong , Liang Liangliang , Chanthapally Anjana , Bolla Geetha , Quah Hong Sheng , Liu Xiaogang , Loh Kian Ping , Dinnebier Robert E. , Xu Qing‐Hua , Vittal Jagadese J. 
Published: October 2019

AbstractInterpenetration in metal–organic frameworks (MOFs) is an intriguing phenomenon with significant impacts on their properties, and functional applications. Herein, we show that a 7‐fold interpenetrated MOF (1) is transformed into an 8‐fold interpenetrated MOF by the loss of DMF in a single‐crystal‐to‐single‐crystal manner. This is accompanied by a giant enhancement of the second harmonic generation (SHG ca. 125 times) and two‐photon photoluminescence (ca. 14 times). The strengthened π–π interaction between the individual diamondoid networks and intensified oscillator strength of the molecules aid the augment of dipole moments and boost the nonlinear optical conversion efficiency. Large positive and negative thermal expansions of 1 occur at 30–150 °C before the loss of DMF. These results offer an avenue to manipulate the NLO properties of MOFs using interpenetration and provide access to tunable single‐crystal NLO devices.
S‐Adenosyl Methionine Cofactor Modifications Enhance the Biocatalytic Repertoire of Small Molecule C‐Alkylation
Authors: McKean Iain J. W. , Sadler Joanna C. , Cuetos Anibal , Frese Amina , Humphreys Luke D. , Grogan Gideon , Hoskisson Paul A. , Burley Glenn A. 
Published: October 2019

AbstractA tandem enzymatic strategy to enhance the scope of C‐alkylation of small molecules via the in situ formation of S‐adenosyl methionine (SAM) cofactor analogues is described. A solvent‐exposed channel present in the SAM‐forming enzyme SalL tolerates 5′‐chloro‐5′‐deoxyadenosine (ClDA) analogues modified at the 2‐position of the adenine nucleobase. Coupling SalL‐catalyzed cofactor production with C‐(m)ethyl transfer to coumarin substrates catalyzed by the methyltransferase (MTase) NovO forms C‐(m)ethylated coumarins in superior yield and greater substrate scope relative to that obtained using cofactors lacking nucleobase modifications. Establishing the molecular determinants that influence C‐alkylation provides the basis to develop a late‐stage enzymatic platform for the preparation of high value small molecules.
Catalytic Difunctionalization of Unactivated Alkenes with Unreactive Hexamethyldisilane through Regeneration of Silylium Ions
Authors: Wu Qian , Roy Avijit , Irran Elisabeth , Qu Zheng‐Wang , Grimme Stefan , Klare Hendrik F. T. , Oestreich Martin 
Published: October 2019

AbstractA metal‐free, intermolecular syn‐addition of hexamethyldisilane across simple alkenes is reported. The catalytic cycle is initiated and propagated by the transfer of a methyl group from the disilane to a silylium‐ion‐like intermediate, corresponding to the (re)generation of the silylium‐ion catalyst. The key feature of the reaction sequence is the cleavage of the Si−Si bond in a 1,3‐silyl shift from silicon to carbon. A central intermediate of the catalysis was structurally characterized by X‐ray diffraction, and the computed reaction mechanism is fully consistent with the experimental findings.
Metal–Organic Gels from Silver Nanoclusters with Aggregation‐Induced Emission and Fluorescence‐to‐Phosphorescence Switching
Authors: Xie Zengchun , Sun Panpan , Wang Zhi , Li Hongguang , Yu Longyue , Sun Di , Chen Mengjun , Bi Yuting , Xin Xia , Hao Jingcheng 
Published: October 2019

AbstractLuminescent metal nanoclusters (NCs) are emerging as a new class of functional materials that have rich physicochemical properties and wide potential applications. In recent years, it has been found that some metal NCs undergo aggregation‐induced emission (AIE) and an interesting fluorescence‐to‐phosphorescence (F‐P) switching in solutions. However, insights of both the AIE and the F‐P switching remain largely unknown. Now, gelation of water soluble, atomically precise Ag9 NCs is achieved by the addition of antisolvent. Self‐assembly of Ag9 NCs into entangled fibers was confirmed, during which AIE was observed together with an F‐P switching occurring within a narrow time scale. Structural evaluation indicates the fibers are highly ordered. The self‐assembly of Ag9 NCs and their photoluminescent property are thermally reversible, making the metal–organic gels good candidates for luminescent ratiometric thermometers.
Self‐healable polyacrylic acid‐polyacrylamide‐ferric ion dual‐crosslinked hydrogel with good biotribological performance as a load‐bearing surface
Authors: Liu Yuntong , Xiong Dangsheng 
Published: October 2019

ABSTRACTAlthough having been widely investigated, polymer hydrogels still have many defects like poor tribological properties and insufficient durability, hindering their further applications in biomedical fields. In this study, we present a simple method to synthesize polyacrylic acid‐polyacrylamide‐ferric ion (PAA‐PAAm‐Fe3+) dual‐crosslinked hydrogels with self‐healing abilities and “soft‐hard” hydrogel‐polyetheretherketone (PEEK) combined load‐bearing surfaces with low friction coefficients. After analytical characterizations, the results demonstrated that the hydrogels could repair themselves without any external stimuli. Because of the excellent biphasic and aqueous lubrication provided by the hydrogel layer and the load‐bearing capacity provided by the PEEK substrate, the friction coefficient of a load‐bearing surface was as low as 0.048 in water, much lower than a pristine PEEK block or a hydrogel block sample. This work fabricated self‐healable PAA‐PAAm‐Fe3+ hydrogels and low friction bearing surfaces, successfully improving the tribology properties of hydrogels, hopefully promoting their applications as biomedical materials such as articular cartilage. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2020, 137, 48499.
Silica‐filled S‐SBR with epoxidized soybean oil: Influence of the mixing process on rheological and mechanical properties of the compound
Authors: Espósito Leandro H. , Marzocca Angel J. 
Published: October 2019

ABSTRACTThe incorporation of epoxidized soybean oil (ESO) in a silica‐filled tread rubber was studied. The aim of this research is to determinate the influence of ESO addition stage on rheological, thermal, mechanical, and viscoelastic properties in the rubber compound. The results suggested that ESO may compete with the silanes in the reaction with silanol groups on the silica surface, interfering with the silanization process. Therefore, a series of ESO‐functionalized silica particles were prepared in which the ESO addition at different conditions were compared to the compound mixing conditions. The presence of covalent bonds by ESO onto silica surface and the changes originated by the silane incorporation were confirmed by Fourier‐transform infrared spectroscopy and thermogravimetric analysis. Consequently, it can be affirmed that the effect of reaction conditions and the sequence of silane/ESO mixing have a strong influence on the final properties of the rubber compound. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2020, 137, 48504.
Cortical morphometry and structural connectivity relate to executive function and estradiol level in healthy adolescents
Authors: Stoica Teodora , Knight Lindsay Kathleen , Naaz Farah , Ramic Melina , Depue Brendan E. 
Published: October 2019

AbstractIntroductionEmotional and behavioral control is necessary self‐regulatory processes to maintain stable goal‐driven behavior. Studies indicate that variance in these executive function (EF) processes is related to morphological features of the brain and white matter (WM) differences. Furthermore, sex hormone level may modulate circuits in the brain important for cognitive function.MethodsWe aimed to investigate the structural neural correlates of EF behavior in gray matter (GM) and WM while taking into account estradiol level, in an adolescent population. The present study obtained neuroimaging behavioral and physiological data from the National Institute of Health's Pediatric Database (NIHPD). We analyzed the relationship between cortical morphometry and structural connectivity (N = 55), using a parent‐administered behavioral monitoring instrument (Behavior Rating Inventory of Executive Function—BRIEF), estradiol level, as well as their interaction.ResultsExecutive function behavior and estradiol level related to bidirectional associations with cortical morphometry in the right posterior dorsolateral prefrontal cortex (pDLPFC) and primary motor cortex (PMC), as well as fractional anisotropy (FA) in the forceps major and minor. Lastly, the interaction of EF behavior and estradiol level related to decreased volume in the right PMC and was linked to altered FA in the right inferior fronto‐occipital fasciculus (iFOF).ConclusionsThe study provides evidence that the relationship between EF behavior and estradiol level related to bidirectional GM and WM differences, implying estradiol level has an influence on the putative structural regions underlying EF behavior. The findings represent a crucial link between EF behavior and hormonal influence on brain structure in adolescence.
Brain activity during traditional textbook and audiovisual‐3D learning
Authors: Pujol Jesus , Blanco‐Hinojo Laura , Martínez‐Vilavella Gerard , Canu‐Martín Lucila , Pujol Anna , Pérez‐Sola Víctor , Deus Joan 
Published: October 2019

AbstractIntroductionAudiovisual educational tools have increasingly been used during the past years to complement and compete with traditional textbooks. However, little is known as to how the brain processes didactic information presented in different formats. We directly assessed brain activity during learning using both traditional textbook and audiovisual‐3D material.MethodsA homogeneous sample of 30 young adults with active study habits was assessed. Educational material on the subject of Cardiology was adapted to be presented during the acquisition of functional MRI.ResultsWhen tested after image acquisition, participants obtained similar examination scores for both formats. Evoked brain activity was robust during both traditional textbook and audiovisual‐3D lessons, but a greater number of brain systems were implicated in the processing of audiovisual‐3D information, consistent with its multisource sensory nature. However, learning was not associated with group mean brain activations, but was instead predicted by distinct functional MRI signal changes in the frontal lobes and showed distinct cognitive correlates. In the audiovisual‐3D version, examination scores were positively correlated with late‐evoked prefrontal cortex activity and working memory, and negatively correlated with language‐related frontal areas and verbal memory. As for the traditional textbook version, the fewer results obtained suggested the opposite pattern, with examination scores negatively correlating with prefrontal cortex activity evoked during the lesson.ConclusionsOverall, the results indicate that a similar level of knowledge may be achieved via different cognitive strategies. In our experiment, audiovisual learning appeared to benefit from prefrontal executive resources (as opposed to memorizing verbal information) more than traditional textbook learning.
Integration of high‐throughput analytics and cell imaging enables direct early productivity and product quality assessment during Chinese Hamster ovary cell line development for a complex multi‐subunit vaccine antigen
Authors: Li Xiangming , Zhang Yujian , Jing Li , Fu Zongming , Ma Ou , Ganguly Jishna , Vaidya Nilesh , Sisson Richard , Naginskaya Jennifer , Chinthala Avinash , Cui Minggang , Yamagata Ryan , Wilson Mark , Sanders Matthew , Wang Zihao , Lo Surdo Paola , Bugno Marcin 
Published: October 2019

AbstractMammalian cell line generation typically includes stable pool generation, single cell cloning and several rounds of clone selection based on cell growth, productivity and product quality criteria. Individual clone expansion and phenotype‐based ranking is performed initially for hundreds or thousands of mini‐scale cultures, representing the major operational challenge during cell line development. Automated cell culture and analytics systems have been developed to enable high complexity clone selection workflows; while ensuring traceability, safety, and quality of cell lines intended for biopharmaceutical applications. Here we show that comprehensive and quantitative assessment of cell growth, productivity, and product quality attributes are feasible at the 200–1,200 cell colony stage, within 14 days of the single cell cloning in static 96‐well plate culture. The early cell line characterization performed prior to the clone expansion in suspension culture can be used for a single‐step, direct selection of high quality clones. Such clones were comparable, both in terms of productivity and critical quality attributes (CQAs), to the top‐ranked clones identified using an established iterative clone screening approach. Using a complex, multi‐subunit antigen as a model protein, we observed stable CQA profiles independently of the cell culture format during the clonal expansion as well as in the batch and fed‐batch processes. In conclusion, we propose an accelerated clone selection approach that can be readily incorporated into various cell line development workstreams, leading to significant reduction of the project timelines and resource requirements.
Systematic reviews as a “lens of evidence”: Determinants of cost‐effectiveness of breast cancer screening
Authors: Mandrik Olena , Ekwunife Obinna Ikechukwu , Meheus Filip , Severens Johan L. (Hans) , Lhachimi Stefan , Uyl‐de Groot Carin A. , Murillo Raul 
Published: October 2019

AbstractSystematic reviews with economic components are important decision tools for stakeholders seeking to evaluate technologies, such as breast cancer screening (BCS) programs. This overview of systematic reviews explores the determinants of the cost‐effectiveness of BCS and assesses the quality of secondary evidence. The search identified 30 systematic reviews that reported on the determinants of the cost‐effectiveness of BCS, including the costs of breast cancer and BCS. While the quality of the reviews varied widely, only four out of 30 papers were considered to be of a high quality. We did not identify publication bias in the original evidence on the cost‐effectiveness of mammography screening; however, we highlight a need for improved clarity in both reporting and data verification. The reviews consisted mainly of studies from high‐income countries. Breast cancer costs varied widely among the studies. Factors leading to higher costs included: time (diagnosis and last months before death), later stage or metastases, recurrence of the disease, age below 64 years and type of follow‐up (more intensive or more specialized). Overall, screening with mammography was considered cost‐effective in the age range 50‐69 years in Western European and Northern American countries but not for older or younger women. Its cost‐effectiveness was questionable for low‐income settings and Asia. Mammography screening was more cost‐effective with biennial screening compared to annual screening and single reading using computer‐aided detection vs double reading. No information on the cost‐effectiveness of ultrasonography was found, and there is much uncertainty on the cost‐effectiveness of CBE because of methodological limitations.
RETRACTED: lncRNA ABHD11‐AS1, regulated by the EGFR pathway, contributes to the ovarian cancer tumorigenesis by epigenetically suppressing TIMP2
Authors: Zeng Xiang‐Yang , Jiang Xiao‐Yan , Yong Jia‐Hui , Xie Hui , Yuan Jing , Zeng Da , Dou Ying‐Yu , Xiao Song‐Shu 
Published: October 2019

AbstractObjectiveEpithelial ovarian cancer (EOC) is a common gynecologic malignancy characterized by extensive peritoneal metastasis and high mortality rate. ABHD11 Antisense RNA1 (ABHD11‐AS1) has recently been identified as a regulator of growth and metastasis in multiple tumors, including EOC. However, the biological function and potential mechanism of ABHD11‐AS1 in EOC remains poorly understood.MethodsImmunohistochemistry, western blot, and qRT‐PCR analysis were used to determine the expression pattern of ABHD11‐AS1 and epidermal growth factor receptor (EGFR) in both EOC tissues and cell lines, respectively. Colony formation, transwell and wound healing assays were performed to evaluate the roles of EGFR and ABHD11‐AS1 on the capacity of cell proliferation, migration, and invasion. Western blot analysis was performed to measure the regulation of EGFR pathway on STAT3. Moreover, chromatin immunoprecipitation was employed to demonstrate the interaction between ABHD11‐AS1 and STAT3. RNA immunoprecipitation was subjected to prove the direct binding between ABHD11‐AS1 and EZH2. Immunofluorescence staining was performed to measure the expression and localization of TIMP2. EOC mouse model was conducted for validating the role of ABHD11‐AS1 in vivo.ResultsEGFR and ABHD11‐AS1 were highly expressed in EOC tissues and cell lines. Knockdown of EGFR or ABHD11‐AS1 inhibited cell growth, migration, and invasion of EOC cells. Expression of ABHD11‐AS1 was regulated by the activation of EGFR signaling pathway, mediated by STAT3. Besides, ABHD11‐AS1 was shown to silence TIMP2 by binding to chromatin‐modifying enzyme EZH2. Furthermore, inhibition of EGFR pathway or ABHD11‐AS1 repressed the tumor growth of EOC.ConclusionWe defined the regulatory relationship between the EGFR signaling pathway, ABHD11‐AS1, EZH2, and TIMP2 suggesting that ABHD11‐AS1 may act as an oncogene and a potential target for antitumor therapies in ovarian cancer.