bluuebunny/crossref_metadata_2025_split huggingface dataset:
Differences of Mohs micrographic surgery in basal cell carcinoma versus squamous cell carcinoma
Authors: Delgado Jiménez Yolanda , Camarero‐Mulas Celia , Sanmartín‐Jiménez Onofre , Garcés Joan R. , Rodríguez‐Prieto Manuel Ã. , Alonso‐Alonso Teresa , Miñano Medrano Roman , López‐Estebaranz Jose L. , de Eusebio Murillo Esther , Redondo Pedro , Ciudad‐Blanco Cristina , Toll Agusti , Artola Igarza Juan L. , Allende Markixana Irati , Suarez Fernández Ricardo , Alfaro Rubio Alberto , Alonso Pacheco Marãa L. , Vázquez‐Veiga Hugo , de la Cueva Dobao Pablo , Ruiz‐Salas Verónica , Vilarrasa Eva , Barchino Lucia , Morales‐Gordillo Victoriano , Ocerin‐Guerra Izascun , Navarro Tejedor Raquel , Hueso Luis , Mayor Arenal Matias , Seoane‐Pose Maria J. , Cano‐Martinez Natividad , Garcia‐Doval Ignacio , Descalzo Miguel A. ,   On behalf of REGESMOHS
Published: September 2018

AbstractBackgroundThe two main tumors treated with Mohs micrographic surgery (MMS) are basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). There are no studies analyzing whether MMS is different when treating these two types of tumors.ObjectiveWe aim to compare the characteristics of the patients, the tumors, and MMS, and first‐year follow‐up of MMS in BCC and SCC.MethodsREGESMOHS is a prospective cohort study of patients treated with MMS. The participating centers are 19 Spanish hospitals where at least one MMS is performed per week. Data on characteristics of the patients, tumors, and surgery were recorded. The follow‐up was done with two visits: the first visit within 1 month after surgery and the second one within the first year.ResultsFrom July 2013 to April 2017, a total of 2,669 patients who underwent MMS were included in the registry. Of them, 2,448 (93%) were diagnosed with BCC, and 181 (7%) were diagnosed with SCC. Patients with SCC were older than those with BCC (median age 73 years vs. 68 years) and presented immunosuppression more frequently. The tumor size was significantly larger in the SCC group. Regarding surgery, deeper invasion was more frequent in SCC, resulting in larger defects. Despite this, SCC did not require more stages to get clear margins or more time in the operating room. Incomplete Mohs was more frequent in the SCC group (6%) than in the BCC group (2%). The incidence of perioperative complications was higher when treating SCC. There were more relapses in the first‐year follow‐up in the SCC group.ConclusionThere are significant differences when comparing MMS in BCC and SCC. Knowledge of these differences can help to prepare the patient and plan the surgery, optimizing results.
Effects of hot‐water and steam blanching of sliced potato on polyphenol oxidase activity
Authors: Moscetti Roberto , Raponi Flavio , Monarca Danilo , Bedini Giacomo , Ferri Serena , Massantini Riccardo 
Published: September 2018

SummaryThe worldwide potato production is considered the fourth‐most important food sector due to the increasing use of potatoes as raw materials for high‐convenience food. Enzymatic browning, due to polyphenol oxidase (PPO), is related to unacceptability by consumer. Among antibrowning agents, thermal treatments are viable alternatives. In this study, the efficacy of hot‐water and steam blanching at 80–90 °C of potato slices (1‐cm thick) was evaluated in terms of colour changes as well as PPO inactivation kinetics, substrate specificity and transition state parameters. In general, all treatments [1] bleached the slices, [2] inactivated PPO and [3] reduced its kinetic efficiency. Results from thermal inactivation kinetics promoted hot‐water blanching at 90 °C for approx. 2 min as the fastest treatment to obtain enzymatic‐stable potato slices. Moreover, steam blanching required more energy (53.93 ± 1.24 kJ mol−1) than hot‐water treatment (41.41 ± 4.51 kJ mol−1) to reach the transition state and then to unfold the PPO enzyme.
Weight‐based victimization from friends and family: implications for how adolescents cope with weight stigma
Authors: Himmelstein M. S. , Puhl R. M. 
Published: September 2018

SummaryBackgroundYouth with overweight and obesity commonly experience weight‐based victimization. The ways that these youth cope with victimization can adversely impact their health. Despite considerable evidence that family members and friends are common perpetrators of weight‐based victimization, the relationships among different sources of victimization and coping responses of youth are unknown.ObjectivesThe present study examined the relationships between weight‐based victimization from four sources (friends, peers, family members and teachers) and stigma‐specific coping responses in adolescents using linear regression.MethodsAdolescents (ages 13–18 years; N = 148) enrolled in a national weight loss camp completed questionnaires about demographics, weight bullying, sources of teasing and internalized weight bias.ResultsTeasing sources explained a large proportion of the variance in coping strategies for weight‐based victimization. Weight teasing from friends was associated with greater frequency of negative emotions. Weight teasing from peers and friends were associated with greater frequency of coping via avoidance behaviours, while teasing from family was associated with fewer avoidance behaviours. Adolescents reported wanting more support from parents and stronger school policies to address weight‐bullying.ConclusionsThese results suggest associations between weight‐teasing sources and coping mechanisms. Interventions should examine the role of coping strategies to protect against adverse health effects of weight‐based victimization.
Experience coercion, post‐traumatic stress, and satisfaction with treatment associated with different coercive measures during psychiatric hospitalization
Authors: Guzmán‐Parra José , Aguilera‐Serrano Carlos , García‐Sanchez Juan Antonio , García‐Spínola Edgar , Torres‐Campos Daniel , Villagrán José María , Moreno‐Küstner Berta , Mayoral‐Cleries Fermín 
Published: September 2018

AbstractCoercive measures are frequently used in psychiatric hospitalization. However, there are few studies that analyse perceived coercion, post‐traumatic stress, and subjective satisfaction with the hospitalization treatment associated with different types of coercive measures. The sample consisted of 111 patients admitted to two psychiatric units and divided into three groups based on the measure applied: involuntary medication (N = 41), mechanical restraint (N = 32), and combined measures (mechanical restraint and involuntary medication; N = 38). The outcome variables were perceived coercion evaluated with the Coercion Experience Scale (CES), post‐traumatic stress evaluated with the Davidson Trauma Scale (DTS), and satisfaction with the treatment evaluated with the Client's Assessment of Treatment (CAT). The results found higher levels of perceived coercion associated with the use of mechanical restraint (P = 0.002) and combined measures (P < 0.001) in comparison with involuntary medication. Additionally, in relation to post‐traumatic stress, mechanical restraint (P = 0.013) and combined measures (P = 0.004) were more stressful compared to involuntary medication. Finally, the use of combined measures was associated with lower satisfaction with inpatient psychiatric treatment compared to the use of involuntary medication (P = 0.006). The following recommendation would be consistent with the results found: if a patient does not specify a preference for some type of measure, involuntary medication could be used and mechanical restraint avoided, especially when used in combination with involuntary medication.
The roles of social identity and dynamic salient group formations for ERP program management success in a postmerger context
Authors: Mueller Stefan K. , Mendling Jan , Bernroider Edward W.N. 
Published: September 2018

AbstractLarge enterprise resource planning (ERP) programs and their critical success factors (CSFs) have been subject to intensive research in recent years. One of the key challenges is their complexity in terms of their duration, context, and social dynamics. The aim of this study is to investigate these matters with the help of an interpretative case study using the coding techniques of the grounded theory method. We extend extant ERP research by introducing a new theoretical perspective that helps to clarify how stakeholder perceptions and CSFs are interrelated, and evolve throughout the life cycle of a large ERP implementation conceptualized as a program in a postmerger context. Using Social Identity Theory as a metatheory for interpretation, we find that different perceptions of opposing salient groups are particularly important. Our result offers a dialectic process view of ERP program implementation success, which (1) considers the different perceptions of salient groups (2) at different points in time (phases) and (3) proposes that a low perceptual fit in relation to a specific CSF contributes to program failure as opposed to (4) a high perceptual fit in relation to the respective CSF, which contributes to program success. We offer a new theoretical lens and propositions for future work highlighting the importance of salient groups and their CSF perceptions for ERP program success. Practitioners can use our findings as a guide towards increasing the probability of success throughout the course of their ERP program life cycles.
Observation and practical implications of nano‐scale phase separation in aluminosilicate glass optical fibers
Authors: Cavillon Maxime , Dragic Peter , Greenberg Bennett , Garofalini Stephen H. , Ballato John 
Published: September 2018

AbstractThis communication provides direct experimental evidence of nano‐scale phase separation in as‐fabricated high‐alumina content (>25 mole percent) optical fibers, experimentally corroborating recent molecular dynamic simulations. In addition, previously incorrect assumptions of glass homogeneity in low‐loss binary aluminosilicate optical fibers are corrected and practical implications for such intrinsically low nonlinearity glass optical fiber amplifiers and lasers are discussed.
Facile preparation of ultralight polymer‐derived SiOCN ceramic aerogels with hierarchical pore structure
Authors: Zhao Wanyu , Shao Gang , Han Shixian , Cai Chunhui , Liu Xingcen , Sun Mengran , Wang Hailong , Li Xinjian , Zhang Rui , An Linan 
Published: September 2018

AbstractSiOCN ceramic aerogels with lightweight, high surface areas, and macro‐meso pores have been synthesized by a facile method combining freeze‐drying technique and polymer‐derived ceramic route. The wet gels are synthesized via the hydrosilylation reaction between polysilazane and divinylbenzene with cyclohexane as solvent. The solvent is then removed by a freeze‐drying process to form pre‐ceramic aerogels. The SiOCN ceramic aerogels are finally obtained by pyrolyzing the pre‐ceramic aerogels at 1000°C in ultrahigh purity N2. The thermogravimetric and mass spectrometry system (TG/DSC‐MS) is used to investigate the polymer‐to‐ceramic conversion process during pyrolysis. The phase composition, structure, and morphology of the SiOCN ceramic aerogels are investigated by XRD, FT‐IR, XPS, and SEM. The results show that SiOCN ceramic aerogels are composed of amorphous matrix phase and “free carbon” phase. The SiOCN aerogels possess three‐dimensional (3D) network porous structure with low density (0.19 g/cm3), high specific surface area (134 m2/g), large pore volume (0.49 cm3/g), and hierarchical pore structures of both macro and meso pores. The formation mechanism and evolution process of SiOCN ceramic aerogels are discussed.
Braving the Waves? Europe's Constitutional Settlement at Twenty
Authors: Nicolaidis Kalypso 
Published: September 2018

AbstractThis article reflects on the diagnosis proposed in 1998 by Moravcsik and Nicolaidis that the EU had reached an incipient constitutional settlement and makes two connected arguments. First, analytically, that contrary to the prevailing view, the EU's constitutional settlement is holding, although it has come under assault from federalists and sovereignists alike. The bicycle theory nevertheless continues to hold sway perhaps because paradigm shifts always exhibit significant lags. Second, normatively, to defend ‘the equilibrium’ does not amount to a defense of the status quo. On the contrary, and especially in the context of the eurozone crisis, we must reflect on the social foundations of the European project, of which intermittent democratic discontent is only one expression. The argument unfolds through four European cities, each regarding a different moment in the Constitutional saga of the last two decades, to conclude on the relationship between LI and demoicratic theory, as well as the promise of sustainable integration.
Short‐term change and prediction of suicidal ideation among adolescents: a daily diary study following psychiatric hospitalization
Authors: Czyz Ewa K. , Horwitz Adam G. , Arango Alejandra , King Cheryl A 
Published: September 2018

BackgroundOur understanding of suicidal ideation (SI) and its risk precursors is largely informed by studies spanning over wide time intervals (weeks, months, years). Little is known about SI as it occurs in daily lives of individuals at risk for suicide, the extent to which suicidal thoughts are dynamic over short periods of time, and the degree to which theoretically informed risk factors predict near‐term SI.MethodsThirty‐four adolescents hospitalized due to last‐month suicide attempt and/or last‐week SI (76% female; ages 13–17) responded to daily surveys sent to their cell phones for four consecutive weeks after discharge (n = 652 observations).ResultsThere was notable variability in day‐to‐day SI, with half of ideation ratings changing at least one within‐person standard deviation from one day to the next. Results of mixed effects models revealed concurrent (same‐day), but not short‐term prospective (next‐day), associations between SI (frequency, duration, urge) and well‐established predictors (connectedness, burdensomeness, hopelessness). However, synergistic effects of low connectedness with either high burdensomeness or high hopelessness were reliably associated with more severe same‐ and next‐day suicidal ideation.ConclusionsThis study adds to emerging literature indicating that suicidal thoughts fluctuate considerably among individuals at risk for suicide, further extending it by focusing on adolescents in the critical posthospitalization period. Fostering high‐risk adolescents’ sense of connectedness to others may be an especially promising intervention target. Frequent assessment of SI and its predictors, independently and in combination, could help identify promising predictors of short‐term risk and meaningful intervention targets in high‐risk teens.
Treatment use and satisfaction among patients with psoriasis and psoriatic arthritis: results from the NORdic PAtient survey of Psoriasis and Psoriatic arthritis (NORPAPP)
Authors: Tveit K.S. , Duvetorp A. , Østergaard M. , Skov L. , Danielsen K. , Iversen L. , Seifert O. 
Published: September 2018

AbstractBackgroundThere are scarce data in Scandinavia about treatment satisfaction among patients with psoriasis (PsO) and/or psoriatic arthritis (PsA). The number of patients receiving systemic treatment is unknown.ObjectiveTo describe patients’ experience of treatments for PsO/PsA in Sweden, Denmark and Norway, addressing communication with physicians, satisfaction with treatment and concerns regarding treatment options.MethodsThe NORdic PAtient survey of Psoriasis and Psoriatic arthritis (NORPAPP) asked 22 050 adults (randomly selected from the YouGov panels in Sweden, Denmark and Norway) whether they had PsO/PsA. A total of 1264 individuals who reported physician‐diagnosed PsO/PsA were invited to participate in the full survey; 96.6% responded positively.ResultsSystemic treatment use was reported by 14.6% (biologic: 8.1%) of respondents with PsO only and by 58.5% (biologic: 31.8%) of respondents with PsA. Biologic treatments were more frequently reported by respondents considering their disease severe (26.8% vs 6.7% non‐severe) and those who were members of patient organizations (40.7% vs 6.9% non‐members). Discussing systemic treatments with their physician was reported significantly more frequently by respondents with PsA, those perceiving their disease as severe (although 35.2% had never discussed systemic treatment with their physician) and those reporting being a member of a patient organization (P < 0.05). Many respondents reported health risk concerns and dissatisfaction with their treatment. Of special interest was that respondents aged 45–75 years reported less experience with biologics (8.1%) than those aged 18–44 years (21.5%). The older respondents also reported more uncertainty regarding long‐term health risks related to systemic treatments (most [66.7–72.9%] responded ‘do not know’ when asked about the risk of systemic options).ConclusionIt appears likely that substantial numbers of Scandinavians suffering from severe PsO/PsA are not receiving optimal treatment from a patient perspective, particularly older patients. Also, one‐third of respondents with severe symptoms had never discussed systemic treatment with a physician.
Pregnancy complications, treatment characteristics and birth outcomes in women with atopic dermatitis in Denmark
Authors: Hamann C.R. , Egeberg A. , Wollenberg A. , Gislason G. , Skov L. , Thyssen J.P. 
Published: September 2018

AbstractBackgroundThe risk of prenatal, obstetric and birth complications in mothers with atopic dermatitis (AD), along with treatment use during pregnancy, is unknown.ObjectivesTo examine the associations between prenatal, obstetric and birth complications in mothers with AD and describe the dermatologic care received during pregnancy.MethodsMother‐child pairs, in which the mother had a history of AD, were identified through the Danish Medical Birth Registry and matched 1 : 10 with non‐AD pairs. Data on dermatologic treatment and prenatal, obstetric and birth complications were obtained through linkage via nationwide registers. Multiple logistic regression was performed.ResultsWe identified 10 668 births from 1997 through 2014 to women with AD. Women with a hospital/ambulatory contact for AD during pregnancy had increased topical corticosteroid and ultraviolet therapy use during pregnancy compared to prior. However, overall, women with AD received decreased dermatologic therapy during pregnancy compared to prior. In adjusted analysis, maternal AD was inversely associated with gestational diabetes [OR 0.79, 95% CI (0.68–0.92)], but positively associated with premature rupture of membranes [1.15 (1.05–1.27)] and staphylococcal neonatal septicemia [2.45 (1.33–4.49)]—albeit the latter was rare. These associations did not meet statistical significance in sub‐analysis where body mass index data were available. No associations were found with preeclampsia, prematurity or non‐staphylococcal neonatal septicaemia.ConclusionsWomen with AD during pregnancy mainly used topical corticosteroids and ultraviolet therapy to control their disease. While premature rupture of membranes and staphylococcal neonatal septicaemia were over‐represented in maternal AD, no associations were found with any other significant prenatal, obstetric or birth outcome.
Accuracy of tele‐consultation on management decisions of lesions suspect for melanoma using reflectance confocal microscopy as a stand‐alone diagnostic tool
Authors: Scope A. , Dusza S.W. , Pellacani G. , Gill M. , Gonzalez S. , Marchetti M.A. , Rabinovitz H.S. , Marghoob A.A. , Alessi‐Fox C. , Halpern A.C. 
Published: September 2018

AbstractBackgroundDiagnostic accuracy of reflectance confocal microscopy (RCM) as a stand‐alone diagnostic tool for suspect skin lesions has not been extensively studied.ObjectivePrimary aim was to measure experts’ accuracy in RCM‐based management decisions. Secondary aim was to identify melanoma‐specific RCM features.MethodsThe study enrolled patients ≥18 years that underwent biopsy of skin lesions clinically suspected to be melanoma. One hundred lesions imaged by RCM were randomly selected from 439 lesions prospectively collected at four pigmented lesion clinics. The study data set included 23 melanomas, three basal cell and two squamous cell carcinomas, 11 indeterminate melanocytic lesions and 61 benign lesions including 50 nevi. Three expert RCM evaluators were blinded to clinical or dermoscopic images, and to the final histopathological diagnosis. Evaluators independently issued a binary RCM‐based management decision, ‘biopsy’ vs. ‘observation’; these decisions were scored against histopathological diagnosis, with ‘biopsy’ as the correct management decision for malignant and indeterminate lesions. A subset analysis of 23 melanomas and 50 nevi with unequivocal histopathological diagnosis was performed to identify melanoma‐specific RCM features.ResultsSensitivity, specificity and diagnostic accuracy were 74%, 67% and 70% for reader 1, 46%, 84% and 69% for reader 2, and 72%, 46% and 56% for reader 3, respectively. The overall kappa for management decisions was 0.34. Readers had unanimous agreement on management for 50 of the 100 lesions. Non‐specific architecture, non‐visible papillae, streaming of nuclei, coarse collagen fibres and abnormal vasculature showed a significant association with melanoma in the evaluation of at least two readers.ConclusionsReflectance confocal microscopy tele‐consultation of especially challenging lesions, based on image review without benefit of clinical or dermoscopy images, may be associated with limited diagnostic accuracy and interobserver agreement. Architectural and stromal criteria may emerge as potentially useful and reproducible criteria for melanoma diagnosis.
Cytonuclear incongruences hamper species delimitation in the socially polymorphic desert ants of theCataglyphis albicansgroup in Israel
Authors: Eyer Pierre‐André , Hefetz Abraham 
Published: September 2018

AbstractAssessing whether behavioural, ecological or geographical factors trigger population divergence provides key insights into the biological processes driving speciation. Recent speciation in restricted geographic area without obvious ecological barriers prompts the question of the behavioural mechanisms underlying species divergence. In this context, we investigated phylogenetic relationships in theCataglyphis albicansdesert ant complex in Israel. We first determined accurate species delimitation using two mitochondrial and six nuclear genes, as well as 11 microsatellite markers to investigate cryptic species in this group, assessing reduction in gene flow between populations. We then investigated whether different species in this group exhibit distinct reproductive strategies, inferring social structure and queen‐mating frequency in each species uncovered. Our findings highlight the presence of at least six distinctCataglyphis albicansspecies in the restricted range of Israel; four of them co‐occur in a 50 × 50 km area in North Negev, while two are endemic from there. However, our results reveal incongruences between nuclear and mitochondrial clustering, which complicate species identification and preclude the exclusive use of mtDNAto confidently delimit species in this group. Finally, we show that the different species of theC. albicansgroup in Israel exhibit quite similar reproductive strategies with most of them having colonies headed by a single queen mated with several males; colonies of one species were, however, headed by several queens. Overall, this weak variation across species thereby unlikely represents the main evolutionary force behind speciation of these sympatric species. We then discuss the potential evolutionary processes that underlie speciation in this group in the absence of clear geographical or ecological barriers.