bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of Boswellia serrata Supplementation on Cytokines Profile, Antioxidant Status and NF-KB Expression in the Spleen and Thymus of Rats
Authors: Alahmari Abeer , Al-Doaiss Amin A. 
Published: November 2024

Background: Boswellia serrata (BS) is one of the medicinal plants that possess antioxidant and anti-inflammatory activities. This study aimed to investigate BS resin effect on cytokine levels, antioxidant status and NF-κB expression in the spleen and thymus of rats in a dose-dependent manner. Methods: Twenty male rats were divided equally into four groups. The 1st group was served as a control, while the 2nd, 3rd and 4th groups were treated orally with gradual doses of BS (50, 100 and 150 mg/kg). After 30 days, all rats were sacrificed and their serum, spleen and thymus were collected for estimating the cytokines (IL-1α, IL-1β, IL-6 and TNF-α) levels and for the analysis of antioxidant markers (superoxide dismutase, catalase, glutathione and total antioxidant capacity). NF-κB expression and histopathological examination of the spleen and thymus were also studied. Result: Our results showed the IL-6 level significantly increased in response to all dosages of the BS. While the high dose of BS (H-BS) led to a significant increase in IL-1β level, histopathological alterations in the spleen and thymus and intense expression of NF-κB in the red pulp of the spleen. We also noticed that the H-BS led to a highly increase in the levels of glutathione and total antioxidant capacity compared to control. Our results provide evidence that the intake of BS in specified dosages can boost the immune system and may have advantageous health effects on cellular redox homeostasis due to its rich content of sesquiterpenoids and triterpenoids.
Inflammation and Microbial Translocation Correlate with Reduced MAIT Cells in People with HIV
Authors: Ryu Angela , Clagett Brian , Freeman Mike 
Published: November 2024

Background: Optimal control of microbial infections requires mucosal-associated invariant T (MAIT) cells. People living with HIV (PWH) on antiretroviral therapy (ART) can be divided into 2 groups: immune responders (IR) who recover or retain CD4 T cell numbers, and immune non-responders (INR) who do not. Compared to IR, INR have fewer MAIT cells and increased systemic inflammation and microbial translocation, but how these factors affect MAIT cells is unknown.
Methods: MAIT cells from IR, INR, and from controls without HIV were enumerated and characterized by flow cytometry. To determine the links among MAIT cells, inflammation, and microbial translocation, the correlations of MAIT cell numbers to previously published soluble inflammatory markers and plasma microbial genetic sequences were assessed by Spearman analysis. In vitro assays were used to support our findings.
Results: MAIT cell numbers were significantly negatively correlated with levels of IL-6 and IP-10 (markers of inflammation); CD14, LPS, and FABP2 (markers of microbial translocation); and with abundance of Serratia and other Proteobacteria genetic sequences in plasma. In a separate analysis of PWH on ART receiving the IL-6 receptor antagonist tocilizumab (TCZ), we found that blocking IL-6 signaling with TCZ increased IL-7 receptor expression on MAIT cells and reduced plasma IL-7 levels, consistent with improved uptake of IL-7 in vivo.
Conclusions: Our findings suggest inflammation and microbial translocation in PWH on ART lead to a loss of MAIT cells via impaired IL-7 responsiveness, resulting in further increased microbial translocation and inflammation.
Sosialisasi Kebun Dapur Keluarga untuk Peningkatan Ketahanan Pangan Keluarga di Desa Jerowaru Lombok Timur
Authors: Nashruddin Muhammad , Anwar Muhammad , Prasetyowati Rini Endang , Iskandar Muhammad Joni 
Published: November 2024

Indonesia faces the problem of food insecurity. The complexity of food insecurity that leads to a food security crisis can be simplified by focusing on three different but interrelated dimensions, namely access to food, household access to food, and individual food use. Mitigating food insecurity through the family kitchen garden program can be carried out with a community involvement approach, especially women, by utilizing home gardens, to provide access to food and vegetables for community members. The implementation method uses Participatory Rural Appraisal, with target partners namely groups of women farmers. The implementation stages consist of planning, preparation, implementation and evaluation. All stages of service activities can be carried out thoroughly and all components work optimally. The average percentage of indicator achievement is 92.5%. Of the four indicators, the level of participant participation occupies the highest percentage, during the activity the attendance and activeness of service participants is maximum.

Abstrak
Indonesia menghadapi masalah kerawanan pangan. Kompleksitas kerawanan pangan yang berujung pada krisis ketahanan pangan dapat disederhanakan dengan berfokus pada tiga dimensi yang berbeda namun saling terkait, yaitu akses terhadap pangan, akses rumah tangga terhadap pangan, dan penggunaan pangan individu. Mitigasi kerawanan pangan melalui program kebun dapur keluarga dapat dilakukan dengan pendekatan pelibatan masyarakat khususnya kaum perempuan dengan pemanfaatan pekarangan rumah, guna akses kesediaan pangan dan sayuran warga masyarakat. Metode pelaksanaan menggunakan Participatory Rural Appraisal, dengan mitra sasaran yaitu kelompok wanita tani. Tahapan pelaksanaan terdiri dari perencanaan, persiapan, implementasi, dan evaluasi. Semua tahapan kegiatan pengabdian dapat dilaksanakan secara menyeluruh dan semua komponen berkerja dengan maksimal. Rata-rata persentase capaian indikator sebesar 92,5%. Dari ke empat indikator tersebut tingkat partisipasi perserta menempati persentase tertinggi, selama kegiatan berlangsung kehadiran dan keaktifan peserta pengabdian maksimal.
Gadolinium-Enhanced 3-Dimensional MRI for Diagnosis and Surgical Planning of Posterior Epidural Migration of Lumbar Disc Fragment
Authors: Koike Yoshinao , Kajino Tomomichi , Dobashi Shinya , Iwasaki Norimasa 
Published: November 2024

Case:
A 34-year-old man presented at our hospital with knee collapse. Magnetic resonance imaging (MRI) revealed posterior compression of the dural sac by a lumbar epidural lesion; however, a diagnosis could not be reached. Gadolinium (Gd)-enhanced 3-dimensional MRI (3D-MRI) clearly delineated the morphology, enabling us to make a preoperative diagnosis of posterior epidural migration of the lumbar disc fragment (PEMLDF). Furthermore, detailed location information enabled surgical removal of the lesion in a minimally invasive manner.

Conclusions:
PEMLDF is rare and often difficult to diagnose. Gd-enhanced 3D-MRI provides useful information for the diagnosis and surgical planning for PEMLDF.
Intradural Disk Herniation at the Conus Medullaris
Authors: Kelly Michael J. , Burkhard Marco D. , Altorfer Franziska C.S. , Emerson Ronald G. , Sama Andrew A. 
Published: November 2024

Case:
A 73-year old man who underwent previous L2-S1 decompression presenting with new right radicular leg pain. Imaging suggests a large central disk herniation at L1-2 with possible intrathecal extension requiring surgical decompression. When positioned prone on a Jackson frame, neuromonitoring motor signals became diminished, and thus, the case was aborted. On returning to the operating room 2 days later, careful positioning in a more neutral/flexed position facilitated normal neuromonitoring signals, allowing for an uneventful intradural approach and discectomy.

Conclusion:
With conus-level intrathecal disk herniation, consider using prepositional neuromonitoring and avoid hyperextension with positioning to ensure neurological safety.
Hallazgos tomográficos como predictores de reincorporación laboral post COVID leve a moderado de los trabajadores de una empresa de fundición de metales no ferrosos
Authors:   , Urtecho Jimenez Samuel Elias , Perales Alanoca Oscar David 
Published: November 2024

Antecedentes: El COVID-19, en la mayoría de los casos leves a moderados, se presenta con compromiso pulmonar variable en la tomografía computarizada. Sin embargo, este grupo ha sido menos estudiado que los casos severos, especialmente en lo referido a las repercusiones ocupacionales. El objetivo del presente estudio es establecer la relación de los hallazgos tomográficos con el tiempo que toma la reincorporación laboral post COVID-19 leve a moderado en los trabajadores de una empresa de fundición de metales no ferrosos. Materiales y métodos:	Estudio de enfoque cuantitativo, analítico, no experimental, correlacional. Se evaluaron las fichas clínicas de 51 trabajadores de la empresa, afectados por COVID-19 leve a moderado entre mayo y setiembre 2020.
Se considera el tiempo de reincorporación hasta un (01) día antes de trabajar en la modalidad presencial, independiente de la alta médica en el centro asistencial. Se realiza el diagnostico de COVID-19 según cuadro clínico compatible, prueba de anticuerpos y/o prueba molecular positiva y/o tomografía compatible. Resultados: Los resultados del estudio revelaron una correlación significativa entre el grado de compromiso pulmonar detectado en la tomografía computarizada y el tiempo de reincorporación laboral. Se observó que a medida que aumentaba el compromiso pulmonar por tomografía, se prolongaba el tiempo necesario para la reincorporación laboral. Además, se encontró que los hallazgos tomográficos, que mostraron un compromiso del 20% al 45%, no estuvieron correlacionados con el número de signos o síntomas. Sin embargo, sí se estableció una correlación entre estos hallazgos y un tiempo medio de reincorporación laboral de 38 días, en comparación con los trabajadores que no presentaron compromiso pulmonar por tomografía, los cuales tuvieron una ausencia promedio de 20 días. Conclusiones: Los resultados indican que el mayor compromiso pulmonar detectado en la tomografía computarizada puede asociarse con un mayor tiempo de ausencia laboral...
Molecular mechanism of culinary herb Artemisia argyi in promoting lifespan and stress tolerance
Authors: Wang Jinsong , Cui Hailin , Xu Yan , Shang Shuyou , Miao Yuanxin , Li Rong , Xu Zhimin 
Published: November 2024

Abstract

Artemisia argyi Lévl. et Vant. (A. argyi) leaf possesses various health promoting functions contributed by its main bioactive flavonoids.In this study, the anti-aging effect and mechanism of Artemisia argyi leaf extract (AALE) were identified using Caenorhabditis elegans (C. elegans) as a model. The results showed that the AALE promoted the lifespan and stress resistance of C. elegans. Meanwhile, the AALE treated C. elegans had high physical activity and low lipofuscin accumulation without negative impact on body size. It was found that the AALE boosted the expression of oxidative stress-related proteins by regulating the insulin/ IGF-1 signaling (IIS) pathway, which then activated the transcription factors DAF-16/FOXO. The results of RNA-sequence analysis indicated that the changes of genes in nematodes treated with AALE were associated with the responses against oxidative stress, cell maturation, and immune reaction, and stress. The qPCR results indicated that the AALE obviously up-regulated the expression of genes related to antioxidant activity and lipid and carbohydrate metabolisms. These findings reveal the mechanism of health prompting function of Artemisia argyi leaf at molecular genetic level. The positive results obtained from the highly conserved signaling pathways of C. elegans model suggest that Artemisia argyi leaf could have the robust benefits for improving healthy aging as well as preventing aging-related diseases in the human body.
An Evaluation of Artificial Intelligence Applications in Learning English through the Multi-complementary Approach
Authors: BATDI Veli , JIBRIL Shafiyu 
Published: November 2024

Abstract

This study aims to evaluate the applications of artificial intelligence (AI) in learning English. A multi-complementary approach (McA) was adopted as a research design to achieve this. A multi-complementary approach integrates multi-analysis as i) meta-analysis and meta-thematic analysis (pre-complementary) phase; at this stage, in the meta-analysis, the effect of artificial intelligence on learning was found to be 0.063, indicating an average effect size. ii) an experimental design of the pre-and post-test (post-complementary) phase; at this phase, the pre-test assessment results showed non-significant differences while the post-test assessment test results showed a significant improvement in academic achievement in the experimental group using artificial intelligent application compared to control with traditional method of learning. iii) the final phase of the research design is the complementary knowledge phase, where the results from the two previous phases were integrated to evaluate their affinity. At this phase, post-complementary results showed a significant impact of artificial intelligence on the academic performance of students who used artificial intelligence applications for learning English, thereby complementing the pre-complementary findings. In conclusion, the study emphasises the positive impact of artificial intelligence applications on English language learning outcomes. Despite some challenges faced by students, the integration of artificial intelligence applications into teaching-learning environments is important for enhancing students' academic achievements and fostering a more engaging and interactive learning experience. By addressing the challenges and harnessing the potential of artificial intelligence technologies, educators can create more effective and personalised language learning experiences for students.
Cellulose Nanocrystals Prepared by Different Methods as Toughening Agents in Sodium Alginate/Polyacrylamide Hydrogels for Flexible Sensors
Authors: Che Wenrong , He Ziyang , Chi Yuhang , Li Baohui , Zheng Jianwei , Zeng Xianhai , Zuo Miao 
Published: November 2024

Abstract

Cellulose nanocrystal (CNC) is one of the most important biomass-derived materials for reinforcing hydrogels. Nevertheless, there is a lack of comparative studies examining the impact of CNC synthesized viadisparate methodologies on the toughening of hydrogels. This study synthesized two different CNCs through the sulfate hydrolysis and deep eutectic solvent (DES) synthesis methods from Gleditsia sinensis peel, a forest residue, and compared their effects on the enhancement of the mechanical properties of SA/PAAM hydrogels. The comprehensive characterizations demonstrated that the mechanical properties of hydrogels derived from DES-CNC are superior to those derived from S-CNC. The DES-CNC/SA/PAAM hydrogels revealed a homogeneous structure with excellent strain (2534%), high transparency (90%), and self-adhesiveness (15 kPa). The flexible sensor assembled using hydrogels exhibited accurate real-time monitoring capabilities for minor and larger strains during movement. To investigate the enhancement mechanism of CNCs on hydrogels, this work evaluated weak interaction forces between DES-CNC/SA/PAAM components through the quantum chemical theoretical calculations, with the combination of wave function analysis method and Molecular dynamics (MD) simulation. This work provides comparative tests of forestry biomass sources in hydrogel synthesis and sensing applications and suggests a new idea for high-value utilization of biomass feedstocks.
Effectiveness of Resilience Training and Experience Sharing in a Virtual Support Group on Increasing Hope for Life in Diabetic Patients with Amputation at Velayat Hospital, Mashhad
Authors: Bideskan Samaneh Safari , Khalvati Maliheh , Gharebaghi Soraya , Kamyar Mohammad Mahdi , Darabi Zahra , Gharetikan Ali Rabbani , Kamalipour Sara 
Published: November 2024

Abstract

Background and Aim: Amputation is a significant life disruption, often stemming from diabetes, leading to mental and emotional distress in affected individuals. Resilience training may help improve the emotional state and instill hope in these patients. This study aimed to evaluate the effectiveness of resilience training and experience sharing in a virtual support group on enhancing hope for life among diabetic amputees at Velayat Hospital, Mashhad, in 2023.
Methods: This quasi-experimental study utilized a pre-test and post-test design with a control group. A sample of 30 diabetic amputee patients from Velayat Hospital was randomly assigned to experimental (n=15) and control (n=15) groups between January 20 and April 19, 2023. Data were collected using a demographic information checklist and Miller's hope for life questionnaire, analyzed via SPSS software (version 23) with independent two-sample t-tests.
Results: Among the 30 participants, 22 (73.3%) were male, with an age range of 43 to 74 years (mean age: 57.73, SD: 8.34). Initially, males displayed higher hope for life scores, but post-intervention, females showed greater increases. There was a statistically significant difference between hope for life scores before (Mpre=152.20, SDpre=19.86) and after (Mpost=173.66, SDpost=13.33) the intervention (P=0.001, t=-4.285). This indicates a significant positive effect of the resilience training on hope scores (Cohen’s d(SMD): -1.26).
Conclusion: Education and patient engagement in treatment significantly enhance quality of life and reduce anxiety, confirming the efficacy of resilience training and experience sharing among diabetic amputee patients.
Photodynamic therapy in the complex treatment of trophic ulcers of venous etiology
Authors: Boldin B. V. , Bogachev V. Yu. , Somov N. O. , Varich G. A. , Golosnitskiy P. Yu. , Komov K. V. 
Published: November 2024

Introduction. In Russia, more than 5 million people suffer from venous ulcers. According to general studies, in more than 10% of cases, venous ulcers lead to permanent disability in patients. Currently, there is a growing interest in the use of photodynamic therapy (PDT), which has already proven its effectiveness in various fields of medicine.Aim. To improve treatment outcomes in patients with venous trophic ulcers by incorporating photodynamic therapy into complex treatment.Materials and methods. A prospective comparative study was conducted in 213 patients with CEAP C6. In the main group (n = 100), treatment was carried out using photodynamic therapy. The control group (n = 113) received standard treatment for venous ulcers.Results. The bacteriological study revealed significant statistical differences in the reduction in the level of bacterial contamination in patients of the main group compared to the control group. A comparison of the standard treatment of venous ulcers and the treatment method using PDT for the entire period of treatment showed that the use of PDT in the complex treatment of venous ulcers reduces the time for clearing ulcers by 1.75 times, accelerates the appearance of granulation tissue by 1.66 times, and accelerates healing by 1.87 times (p < 0.05).Discussion. The introduction of new medical technologies into clinical practice helps to improve the results of treatment of venous ulcers. The use of PDT in the treatment of venous ulcers has demonstrated high clinical effectiveness.Conclusion. The results of the study convincingly show that photodynamic therapy accelerates reparative processes in the ulcer, improves the state of the microbial background, and, accordingly, accelerates the rate of epithelization of the trophic ulcer.
Navigating Communication in Racially Concordant Care: Considerations for Medical Education
Authors: Anderson LaKesha N. , Taylor Taryn R. , Siwemuke Tylin , Rockich-Winston Nicole , White DeJuan , Wyatt Tasha R. 
Published: November 2024

Background and Objectives: Black/African American medical professionals and students engage in patient-centered communication in ways that are not yet described in medical education literature. The purpose of this paper is to explore the ways in which Black/African American attending physicians, residents, and medical students enact patient-centered communication while interacting with their Black/African American patients.
Methods: Forty-one Black/African American attending physicians, residents, and medical students were recruited through a snowball sample of the authors’ personal and professional networks. Participants engaged in semistructured interviews about their experiences of being Black in a predominantly White profession. Data were transcribed and analyzed using thematic analysis.
Results: Black/African American attending physicians, residents, and medical students used patient-centered communication when engaging with Black/African American patients. Rather than relying on physician-focused styles of communication, participants situated their communication within their shared cultural backgrounds and approached their patients as they would approach family members. Participants reported that by centering the patient, they could communicate in a way that reflects shared norms and understandings.
Conclusions: This study suggests that Black/African American attending physicians, residents, and medical students approach communication from a personal and familial space in an effort to disrupt conventional modes of provider-patient communication that do not center the patient or consider the patient’s cultural background.
Test de vulnerabilidad = Vulnerability test
Authors: Gómez Zavaglia Tristán 
Published: November 2024

El test de vulnerabilidad es una de las herramientas que poseen los distintos operadores del sistema jurídico para determinar en ciertas situaciones si corresponde o no ejercitar la tutela reforzada de la cual son acreedores estas personas o grupos. Los pronunciamientos de la Corte Interamericana de Derechos Humanos –compatibilizados con nuestra realidad socio-cultural y jurídica- son una guía indispensable para poder llevar adelante este cometido central.

ABSTRACT: The vulnerability test is one of the tools that the different operators of the legal system have to determine in certain situations whether or not it is appropriate to exercise the reinforced protection of which these persons or groups are creditors. The pronouncements of the Inter-AmericanCourt of Human Rights -made compatible with our socio-cultural and legal reality- are an essential guide to be able to carry out this central task.
Reflexiones sobre la tentativa en el derecho penal justinaneo = Reflections on attempt in justinaneo criminal law
Authors: Peretti Ávila Diego 
Published: November 2024

El presente trabajo tiene como objetivo principal el abordaje del problema de la tentativa de delitos en el Derecho Penal romano, correspondiente al periodo justinianeo. Existen opiniones encontradas entre los especialistas y estudiosos del Derecho Romano en cuanto a si este pueblo prodigioso pudo llegar a distinguir jurídicamente entre delito consumado y el instituto de la tentativa. Por nuestra parte, entendemos que, si no se puede hablar de un Derecho Penal Romano autónomo, mucho menos podemos referirnos a una teoría de la tentativa de delitos, lo que no quiere decir que los romanos no hayan podido llegar a diferenciar ciertas características propias de este instituto a partir de la noción de protección de la norma. Algo bastante parecido al germen de la noción de “bien jurídico protegido”.

ABSTRACT: The main objective of this paper is to address the problem of attempted crimes in Roman Criminal Law in the Justinian period. There are conflicting opinions among specialists and scientists of Roman Law as to whether this prodigious people was able to legally distinguish betweenthe consummated crime and the institute of criminal attempt. We hold that, if it is not possible to speak of an autonomous Roman Criminal Law, much less can we talk about an attempted crime theory, which does not mean that the Romans could not differentiate certain characteristics of this institute from the scope of protection of criminal law. It would be something quite similar to the germ of the notion of “legal protected good”.