bluuebunny/crossref_metadata_2025_split huggingface dataset:
Increased incidence of distal humeral fracture surgery and decreased incidence of respective corrective osteotomy among Finns aged 0 to 18 years between 1987 and 2016: A population-based study
Authors: Salonen A. , Niemi S. T. , Kannus P. , Laitakari E. , Mattila V. M. 
Published: July 2019

Purpose Previous studies on paediatric and adolescent distal humeral fractures have reported an increase in surgical treatment activity. This increase could be hypothesized to reduce the incidence of corrective osteotomies. The aim of this study was to determine the incidence and trends of the primary surgical treatment of distal humeral fractures and corrective osteotomies in children and adolescents. Methods All Finns 18 years of age or younger who underwent treatment for distal humeral fracture between 1987 and 2016 were included in this population-based study. Surgical treatment data were obtained from the National Hospital Discharge Register of Finland. In calculating annual surgery incidence rates, the annual mid-year populations were obtained from the Official Statistics Finland. Surgical treatment was categorized into four groups; reposition and casting, osteosynthesis, external fixation and corrective osteotomy. Results During the 30-year study period, 9017 surgical procedures were performed in Finland with the primary or secondary diagnosis code being a distal humeral fracture. Of these, 6961 (77.2%) were osteosynthesis and the incidence of osteosynthesis (per 100 000 person-years) increased fourfold from 8.2 in 1987 to 34.1 in 2016. In the same 30-year study period, the total number of corrective osteotomies was low (151) with annual variation from one to 16. The incidence of corrective osteotomies (per 100 000 person-years) decreased sevenfold from 0.7 to 0.1. Conclusion The incidence of surgical treatment with osteosynthesis in distal humeral fractures increased fourfold in Finland between 1987 and 2016. During the same time period, the number of corrective osteotomies diminished significantly. Level of Evidence IV
Asphyxia Caused by a Giant Fibrovascular Polyp of the Esophagus
Authors: Endara Santiago A. , Dávalos Gerardo A. , Yepez Ramiro J. , Luna Diego F. , Corral Fabián B. , Molina Gabriel A. , Cisneros W. Javier 
Published: July 2019

ABSTRACT
Fibrovascular polyps (FVPs) are rare, benign tumors of the esophagus; they usually appear as an intraluminal mass within the esophagus, which can grow and reach enormous sizes if left untreated. They can cause a variety of symptoms, from mild dysphagia to life-threatening asphyxia. Diagnosis is challenging because FVPs can resemble any respiratory condition, which can lead to misdiagnosis and potentially dangerous therapies. We present a 47-year-old man who suffered from recurrent episodes of odynophagia. This time he suffered an incident of severe asphyxia and loss of consciousness. After complementary examinations, an FVP was detected and successfully treated.
Severe Primary Sclerosing Cholangitis Biliary Stricture Managed With a Small-Caliber Cardiac Angioplasty Balloon: Looking Outside the Endoscopic Retrograde Cholangiopancreatography Toolbox
Authors: Simons-Linares C. Roberto , O'Shea Robert , Chahal Prabhleen 
Published: July 2019

ABSTRACT
Primary sclerosing cholangitis leads to biliary obstruction through a dominant biliary stricture. Endoscopic management of biliary strictures with balloon dilation is preferred over percutaneous radiological or surgical interventions. High-grade biliary strictures can be challenging to manage endoscopically because the traditional endoscopic retrograde cholangiopancreatography accessories fail to traverse these severely stenotic strictures. We describe a case of endoscopic management of a severe primary sclerosing cholangitis-related distal biliary stricture managed with a cardiac angioplasty balloon after failed attempts using the standard endoscopic retrograde cholangiopancreatography accessories and percutaneous radiological intervention.
Increasing Economic Burden in Hospitalized Patients With Cirrhosis: Analysis of a National Database
Authors: Desai Archita P. , Mohan Prashanthinie , Nokes Brandon , Sheth Deekksha , Knapp Shannon , Boustani Malaz , Chalasani Naga , Fallon Michael B. , Calhoun Elizabeth A. 
Published: July 2019

INTRODUCTION:
The prevalence of cirrhosis is increasing despite advances in therapeutics, and it remains an expensive medical condition. Studies examining the healthcare burden of inpatient cirrhosis-related care regardless of etiology, stage, or severity are lacking. This study aims to describe the current drivers of cost, length of stay (LOS), and mortality in hospitalized patients with cirrhosis.

METHODS:
Using the National Inpatient Sample (NIS) data from 2008 to 2014, we categorized admissions into decompensated cirrhosis (DC), compensated cirrhosis (CC), and NIS without cirrhosis. Descriptive statistics and regression analysis were used to analyze the association between patient characteristics, comorbidities, complications, and procedures with costs, LOS, and mortality in each group.

RESULTS:
The hospitalization costs for patients with cirrhosis increased 30.2% from 2008 to 2014 to $7.37 billion. Cirrhosis admissions increased by 36% and 24% in the DC and CC groups, respectively, compared with 7.7% decrease in the NIS without cirrhosis group. DC admissions contributed to 58.6% of total cirrhotic admissions by 2014. Procedures increased costs in both DC and CC groups by 15%–152%, with mechanical ventilation being associated with high cost increase and mortality increase. Complications are also key drivers of costs and LOS, with renal and infectious complications being associated with the highest increases in the DC group and infections and nonportal hypertensive gastrointestinal bleeding for the CC group.

DISCUSSION:
Economic burden of hospitalized patients with cirrhosis is increasing with more admissions and longer LOS in DC and CC groups. Important drivers include procedures and portal hypertensive and nonportal hypertensive complications.
Melacak Dampak Perubahan Iklim Terhadap Kondisi Makroekonomi dengan Teori Permainan Dinamis
Authors: Musthofa Muhammad Wakhid 
Published: July 2019

Makalah ini membahas tentang model matematika dampak perubahan iklim terhadap kondisi makroekonomi suatu negara. Dengan mengacu pada model pertumbuhan ekonomi endogen pada suatu negara, dengan fungsi output berbentuk fungsi Cobb-Douglas akan diturunkan model matematika yang mendeskripsikan dampak perubahan iklim terhadap kondisi makroekonomi suatu negara. Selanjutnya, akan dikonstruksikan pula fungsi ongkos yang berhubungan dengan model matematika yang telah diturunkan. Mengingat model matematika tersebut masih dalam bentuk sistem persamaan nonlinear, maka diperlukan proses linearisasi untuk menghasilkan model matematika yang linear sehingga memudahkan untuk dianalisis maupun diaplikasikan.
[This paper discusses the mathematical model of the impact of climate change on the macroeconomic conditions of a country. By referring to an endogenous economic growth model in a country, with the output function in the form of a Cobb-Douglas function, a mathematical model will be described that describes the effects of climate change on the macroeconomic conditions of a country. Furthermore, it will also construct cost functions related to mathematical models that have been derived. Considering that the mathematical model is still in the form of a nonlinear equation system, a linearisation process is needed to produce a linear mathematical model that makes it easy to analyze and apply.]
Value of NSE and S100 Protein of Kawasaki Disease with aseptic meningitis in Infant
Authors: Wang Jiangtao , Chen Shouhang , Wang Xiaoling , Gu Huiru , Liu Junli , Wang Xiaohong , Liu Liang 
Published: July 2019

AbstractThe cerebrospinal fluid content was examined for concentrations of S100 protein and neuron-specific enolase (NSE) in two diseases, Kawasaki disease (KD) with aseptic meningitis (1-3 months) and purulent meningitis (PM), to determine whether or not these measuremets could be used in early diagnosis. The content of cerebrospinal fluid S100 protein of KD with aseptic meningitis and PM were significantly higher than those in the control group. There was also a difference between KD and purulent meningitis (PM). The concentration of NSE was highest in the encephalitis group, which was statistically different from control group. However, there was no difference between the KD and control groups. The levels of S100 protein and NSE of KD with aseptic meningitis were lower than those in PM, indicating that the extent of neuronal damage is significantly lower than of the enchephalitis group. The area under the curve (AUCs) of the receiver operating characteristic (ROC) curve for S100 and NSE were both 0.972. The S100 threshold was 0.4315, the sensitivity was 92.1%, and the specificity was 100%, while the NSE threshold was 9.325, sensitivity 92.1%, and specificity 90%. The combined detection of NSE and S100 levels in the cerebrospinal fluid can be used for the differential diagnosis of KD with aseptic meningitis and purulent meningitis.
Endometriosis Pathoetiology and Pathophysiology: Roles of Vitamin A, Estrogen, Immunity, Adipocytes, Gut Microbiome and Melatonergic Pathway on Mitochondria Regulation
Authors: Anderson George 
Published: July 2019

AbstractEndometriosis is a common, often painful, condition that has significant implications for a woman’s fertility. Classically, endometriosis has been conceptualized as a local estrogen-mediated uterine condition driven by retrograde menstruation. However, recent work suggests that endometriosis may be a systemic condition modulated, if not driven, by prenatal processes. Although a diverse array of factors have been associated with endometriosis pathophysiology, recent data indicate that the low body mass index and decreased adipogenesis may be indicative of an early developmental etiology with alterations in metabolic function crucial to endometriosis pathoetiology.The present article reviews the data on the pathoetiology and pathophysiology of endometriosis, suggesting key roles for alterations in mitochondria functioning across a number of cell types and body systems, including the immune system and gut microbiome. These changes are importantly regulated by decreases in vitamin A and its retinoic acid metabolites as well as increases in mitochondria estrogen receptor-beta and the N-acetylserotonin/melatonin ratio across development. This has treatment and future research implications for this still poorly managed condition, as well as for the association of endometriosis with a number of cancers.
Global diversity and geography of planktonic marine fungi
Authors: Hassett Brandon T. , Vonnahme Tobias R. , Peng Xuefeng , Jones E.B. Gareth , Heuzé Céline 
Published: July 2019

Abstract
Growing interest in understanding the relevance of marine fungi to food webs, biogeochemical cycling, and biological patterns necessitates establishing a context for interpreting future findings. To help establish this context, we summarize the diversity of cultured and observed marine planktonic fungi from across the world. While exploring this diversity, we discovered that only half of the known marine fungal species have a publicly available DNA locus, which we hypothesize will likely hinder accurate high-throughput sequencing classification in the future, as it does currently. Still, we reprocessed >600 high-throughput datasets and analyzed 4.9 × 109 sequences (4.8 × 109 shotgun metagenomic reads and 1.0 × 108 amplicon sequences) and found that every fungal phylum is represented in the global marine planktonic mycobiome; however, this mycobiome is generally predominated by three phyla: the Ascomycota, Basidiomycota, and Chytridiomycota. We hypothesize that these three clades are the most abundant due to a combination of evolutionary histories, as well as physical processes that aid in their dispersal. We found that environments with atypical salinity regimes (>5 standard deviations from the global mean: Red Sea, Baltic Sea, sea ice) hosted higher proportions of the Chytridiomycota, relative to open oceans that are dominated by Dikarya. The Baltic Sea and Mediterranean Sea had the highest fungal richness of all areas explored. An analysis of similarity identified significant differences between oceanographic regions. There were no latitudinal gradients of marine fungal richness and diversity observed. As more high-throughput sequencing data become available, expanding the collection of reference loci and genomes will be essential to understanding the ecology of marine fungi.
Implementation of Improved Ship-Iceberg Classifier Using Deep Learning
Authors: Rane Ankita , Sangili Vadivel 
Published: July 2019

Abstract
The application of synthetic aperture radar (SAR) for ship and iceberg monitoring is important to carry out marine activities safely. The task of differentiating the two target classes, i.e. ship and iceberg, presents a challenge for operational scenarios. The dataset comprising SAR images of ship and iceberg poses a major challenge, as we are provided with a small number of labeled samples in the training set compared to a large number of unlabeled test samples. This paper proposes a semisupervised learning approach known as pseudolabeling to deal with the insufficient amount of training data. By adopting this approach, we make use of both labeled data (supervised learning) and unlabeled data (unsupervised learning) to build a robust convolutional neural network model that results in a superior binary classification performance of the proposed method.
Effect of bisphenol-A (BPA) on placental biomarkers for inflammation, neurodevelopment and oxidative stress
Authors: Arita Yuko , Park Hyeon Jeong , Cantillon Aisling , Getahun Darios , Menon Ramkumar , Peltier Morgan R. 
Published: July 2019

Abstract

Background
Bisphenol-A (BPA) is a widespread pollutant whose effects on pregnant women are poorly understood. Therefore, we investigated the effects of BPA on basal and bacteria-stimulated production of proinflammatory cytokines [interleukin (IL)-1β, tumor necrosis factor-α (TNF-α) and IL-6], anti-inflammatory mediators [soluble glycoprotein 130 (sgp) 130, heme oxidase-1 (HO-1) and IL-10] and biomarkers for neurodevelopment [brain-derived neurotrophic factor (BDNF)], and oxidative stress [8-isoprostane (8-IsoP)] by the placenta.

Methods
Placental explant cultures were treated with BPA (0–10,000 nM) in the presence or absence of 107 colony-forming unit (CFU)/mL heat-killed Escherichia coli for 24 h. Biomarker concentrations in conditioned medium were quantified by the enzyme-linked immunosorbent assay (ELISA).

Results
Under basal conditions, IL-1β and IL-6 production was enhanced by BPA in a dose-dependent manner. Sgp130, a soluble receptor that reduces IL-6 bioactivity, was suppressed by BPA at 1000–10,000 nM. BPA also enhanced BDNF production at 1000 and 10,000 nM, and 8-IsoP expression at 10 and 100 nM. For bacteria-treated cultures, BPA increased IL-6 production at 100 nM and reduced sgp130 at 1000 nM but had no effect on IL-1β, TNF-α, BDNF, HO-1, 8-IsoP or IL-10 production.

Conclusion
BPA may increase placental inflammation by promoting IL-1β and IL-6 but inhibiting sgp130. It may also disrupt oxidative balance and neurodevelopment by increasing 8-IsoP and BDNF production.
Crystal structure of 4-ethylpiperazine-1-carbothioic dithioperoxyanhydride, C14H26N4S4
Authors: Ayom Gwaza E. , Khan Malik D. , Zamisa Sizwe J. , Revaprasadu Neerish 
Published: July 2019

Abstract
C14H26N4S4, monoclinic, C2/c (no. 15), a = 16.9951(10) Å, b = 11.4397(7) Å, c = 9.7678(6) Å, β = 103.913(1)°, V = 1843.33(19) Å3, Z = 4, R
gt(F) = 0.0200, wR
ref(F
2) = 0.0553, T = 100(2) K.
Genome-wide identification, phylogeny and expression analysis of G6PC gene family in common carp, Cyprinus carpio
Authors: Liu Sijia , Tian Fei , Zhang Cunfang , Qiao Zhigang , Zhao Kai 
Published: July 2019

Abstract

Objective
The Glucose 6-phosphatase (G6Pase) catalytic subunit (G6PC) catalyzes glucose 6-phosphate (G6P) to inorganic phosphate and glucose, playing a critical role in endogenous energy supply. Here, the G6PC gene family was investigated and characterized in common carp (Cyprinus carpio).

Methods
Sequence alignment and phylogenetic analysis were performed using MEGA5. The HMM profiles, motif structure were analyzed using Pfam and MEME, respectively. Quantitative real-time PCR was used to test the expression profiles.

Results
Four assumptive members of G6PC family in common carp whole-genome sequence were identified as cg6pca.1, cg6pca.2a, cg6pca.2b and cg6pcb which were classified into g6pca and g6pcb subtypes, respectively. Evolutionary analysis revealed that cg6pca.2a and cg6pca.2b have a closer evolutionary relationship, and the same subtype members have higher homology among different species. A classical PAP2-glucose phosphates domain is found in four genes and were highly conserved. The expression patterns revealed that only cg6pca.2a elevated significantly after 12 and 24 h of both starvation and cold treatment (p < 0.05).

Conclusions
This study performed a comprehensive analysis of G6PC gene family in common carp. Moreover, cg6pca.2 may be the major functional gene in cold and fasting stress. And the transfactors, PLAG1 and Sox8, may be concerned with expression regulation of cg6pca.2.
Effects of a 4-Week Neuromuscular Training Program on Movement Competency During the Back-Squat Assessment in Pre– and Post–Peak Height Velocity Male Athletes
Authors: Dobbs Ian J. , Oliver Jon L. , Wong Megan A. , Moore Isabel S. , Myer Gregory D. , Lloyd Rhodri S. 
Published: July 2019

Abstract
Dobbs, IJ, Oliver, JL, Wong, MA, Moore, IS, Myer, GD, and Lloyd, RS. Effects of a 4-week neuromuscular training program on movement competency during the back-squat assessment in pre– and post–peak height velocity male athletes. J Strength Cond Res 35(10): 2698–2705, 2021—The back-squat assessment (BSA) is a novel movement screen to detect functional deficits; however, its sensitivity to detect meaningful changes in movement competency after exposure to short-term neuromuscular training remains unclear. Twenty-six pre– and 22 post–peak height velocity (PHV) males were divided into experimental (EXP) and control groups (CON) and performed the BSA before and after a twice weekly, 4-week neuromuscular training intervention. Intra-rater reliability was determined by rating both EXP group's baseline BSA on 3 separate sessions. Intraclass correlation coefficient (ICC) revealed very strong agreement for BSA total score in pre-PHV (ICC ≥ 0.81) and post-PHV (ICC ≥ 0.97) groups across all sessions, but systematic bias was evident in the pre-PHV group for sessions 1–2. Analysis of kappa values for BSA individual criteria showed greater variability for pre-PHV (K ≥ 0.31) than post-PHV (K ≥ 0.62) across sessions. At baseline, there were no differences in total score between the EXP and CON cohorts (p > 0.05). There were significant within-group improvements in total score for the EXP pre-PHV (5.0 to 3.0, effect size [ES] = 0.68) and post-PHV (2.0 to 1.0, ES = 0.82) cohorts, with no changes in total score for either CON groups (p > 0.05). Hip position was the criterion with the greatest improvement for both the EXP pre-PHV (12.0 to 7.0) and post-PHV (7.0 to 0.0) groups. The BSA seems to be a reliable screening tool for measuring movement competency in youth male athletes and was sensitive to adaptations in movement competency after neuromuscular training.
Determining the Corticospinal Responses to Single Bouts of Skill and Strength Training
Authors: Mason Joel , Frazer Ashlyn K. , Jaberzadeh Shapour , Ahtiainen Juha P. , Avela Janne , Rantalainen Timo , Leung Michael , Kidgell Dawson J. 
Published: July 2019

Abstract
Mason, J, Frazer, AK, Jaberzadeh, S, Ahtiainen, JP, Avela, J, Rantalainen, T, Leung, M, and Kidgell, DJ. Determining the corticospinal responses to single bouts of skill and strength training. J Strength Cond Res 33(9): 2299–2307, 2019—Neuroplastic changes in the primary motor cortex accompany performance improvements following motor practice. Recent evidence suggests that the corticospinal responses to strength and skill training are similar, following both a single session and repeated bouts of training, promoting discussion that strength training is a form of motor learning. However, these findings are limited by the lack of a light-load strength training group. Therefore, the aim of the current study was to determine whether a single session of heavy-load strength training, light-load strength training or skill training differentially modulates the corticospinal pathway. Transcranial magnetic stimulation was used to assess the excitatory and inhibitory circuitry of the motor cortex following a single session of skill training, and following a single session of light-load and heavy-load strength training. Following a single session of training, participants in all groups experienced comparable increases in corticospinal excitability (ranging from 38 to 46%, all p < 0.05); however, disparity was observed in the inhibitory responses. Corticospinal inhibition was reduced in all 3 single-sessions, although to a greater magnitude in the heavy-load and skill-training sessions (22 and 18% respectively, compared with 11% following light-load training, all p < 0.05). Short-interval intracortical inhibition was reduced immediately following single sessions of heavy-load strength training (40% p < 0.05) and skill training (47% p < 0.05), but remained unchanged the following light-load strength training session. It appears that the corticospinal responses to single sessions of different types of strength and skill training are task-dependent. These findings reinforce the notion that strength training, at least when heavily-loaded, can be considered a form of motor learning, potentially because of the sensory feedback involved.
Effects of Citrulline Malate and Beetroot Juice Supplementation on Blood Flow, Energy Metabolism, and Performance During Maximum Effort Leg Extension Exercise
Authors: Trexler Eric T. , Keith Dale S. , Schwartz Todd A. , Ryan Eric D. , Stoner Lee , Persky Adam M. , Smith-Ryan Abbie E. 
Published: July 2019

Abstract
Trexler, ET, Keith, DS, Schwartz, TA, Ryan, ED, Stoner, L, Persky, AM, and Smith-Ryan, AE. Effects of citrulline malate and beetroot juice supplementation on blood flow, energy metabolism, and performance during maximum effort leg extension exercise. J Strength Cond Res 33(9): 2321–2329, 2019—Citrulline malate (CitMal) and beetroot juice (BEET) are increasingly popular ergogenic aids, but few studies have rigorously investigated their effects on resistance exercise performance and underlying mechanisms. The current randomized, double-blind, crossover study evaluated the effects of CitMal and BEET supplementation on blood flow, metabolic efficiency, and performance during maximal isokinetic leg extension exercise. After familiarization, 27 recreationally active men (age: 22 ± 4 years) completed 3 visits in which subjects ingested a treatment beverage (CitMal [8 g], BEET [400-mg nitrate], or placebo [PLA]), followed by a 2-hour rest period, warm-up, and 5 sets of 30 concentric leg extensions. Before and after exercise, ultrasound was used to measure diameter (aDIAM) and blood flow (aBF) of the superficial femoral artery, along with cross-sectional area and echo intensity of the vastus lateralis. Plasma analytes (lactate, nitrate/nitrite [NOx], and urea nitrogen [BUN]) were also assessed at these times, and indirect calorimetry was used to measure energy expenditure and respiratory exchange ratio before and during exercise. Resting NOx values were higher in BEET (233.2 ± 1.1 μmol·L−1) compared with CitMal (15.3 ± 1.1, p < 0.0001) and PLA (13.4 ± 1.1, p < 0.0001). Postexercise NOx values, adjusted for resting differences, were higher in BEET (86.3 ± 1.2 μmol·L−1) than CitMal (21.3 ± 1.1, p < 0.0001) and PLA (18.1 ± 1.1, p < 0.0001). No other variables were affected by treatment (all p > 0.05). While BEET increased NOx, neither treatment was found to enhance performance, blood flow, metabolic efficiency, nor the hormonal response to leg extension exercise.