bluuebunny/crossref_metadata_2025_split huggingface dataset:
Biomechanical analysis of a magnesium plantar plate prototype system for the first tarsometatarsal joint fusion: a cadaveric study
Authors: Zhou Peng , Ribeiro Marx , Greven Johannes , Praster Maximilian , Seitz Jan-Marten , Habicht Simon , Hildebrand Frank , Balmayor Elizabeth R. , Lichte Philipp 
Published: November 2024

Abstract
Background
Titanium plantar plates have proven successful in the fixation of the first tarsometatarsal arthrodesis (TMT). However, a second surgery is typically needed for implant removal, and potential adverse effects, carried by the conventional implantations, are not uncommon. The purpose of this study was to determine whether a novel magnesium-based plantar plate system provides similar fusion stability to a titanium-based plantar plate system under various loading conditions.

Methods
Six matched-pair human cadaveric specimens underwent TMT fusions using either a magnesium plantar plate system prototype or a titanium plantar plate system. Specimens were cyclically loaded with a force ranging from 5 N to 50 N for 5,000 cycles, and displacement was recorded. Axial stiffness (N/mm) was calculated from load-displacement curves. Each specimen was loaded to failure at a rate of 5 mm/min, and the ultimate load was recorded.

Results
No significant difference was found in the vertical displacement between Ti group and Mg group after 100 cycles (2.4 ± 1.0 mm vs. 1.3 ± 1.4 mm, p = 0.196), 500 cycles (3.3 ± 1.3 mm vs. 1.7 ± 1.7 mm, p = 0.142), 1,000 cycles (3.7 ± 1.5 mm vs. 1.9 ± 1.9 mm, p = 0.128), 2,500 cycles (4.2 ± 1.7 mm vs. 2.3 ± 2.2 mm, p = 0.172) and 5,000 cycles (4.5 ± 1.8 mm vs. 2.3 ± 3.3 mm, p = 0.125), Additionally, no significant differences were observed in initial stiffness (53.1 ± 19.2 N/mm vs. 82.2 ± 53.9 N/mm, p = 0.257), final stiffness (90.6 ± 48.9 N/mm vs. 120.0 ± 48.3 N/mm, p = 0.319), or maximum load-to-failure (259.8 ± 98.2 N vs. 323.9 ± 134.9 N, p = 0.369).

Conclusions
Based on the performed biomechanical testing, the magnesium plantar plate system provides mechanical stability equivalent to the titanium plantar plate system in fixation for the first TMT joint fusion.
Support by telestroke networks is associated with increased intravenous thrombolysis and reduced hospital transfers: A german claims data analysis
Authors: Janßen Andreas , Pardey Nicolas , Zeidler Jan , Krauth Christian , Blaser Jochen , Oedingen Carina , Worthmann Hans 
Published: November 2024

Abstract
Background
Acute stroke treatment is time-critical. To provide qualified stroke care in areas without 24/7 availability of a stroke neurologist, the concept of teleneurology was established, which is based on remote video communication through telemedicine organized by telestroke networks. Data on the effectiveness and efficiency of stroke treatment via teleneurology is very scarce and is therefore partly questioned in the healthcare sector. The aim was to evaluate stroke care in hospitals with and without teleneurology in Northern Germany.

Methods
We conducted a retrospective case–control data analysis using health insurance claims data for the years 2018 to 2021. Based on pre-defined criteria, two models were defined and clinical as well as health economic parameters were compared. In model 1, we compared patients from hospitals with and without support by a telestroke network, while in model 2, we compared patients from hospitals with and without support by a telestroke network, including only districts without a certified stroke unit. Assessed parameters were age, length of stay, patients’ comorbidities, inpatient costs, reasons for discharge, qualified stroke care treatment according to operation and procedure codes (OPS) and intravenous thrombolysis (IVT) rates.

Results
Hospitals supported by a telestroke network improved their rate of stroke care according to OPS and increased more than three-fold their IVT rate (p = 0.042). In comparison, patients from hospitals with support by a telestroke network had a higher number and rate of qualified stroke care according to OPS (model 1: 73.6% vs 2.2%, p < 0.001 and model 2: 57.0% vs 3.8%, p < 0.001), higher rate of IVT (model 1: 9.5% vs. 0.0%, p = 0.027 and model 2: 10.3% vs 0.0%, p = 0.056) and a lower rate of secondary transfers to another hospital (model 1: 5.9% vs. 28.9%, p < 0.001 and model 2: 5.6% vs 30.1%, p < 0.001). Inpatient costs were lower in cases treated in hospitals with support by a telestroke network (model 1: 4,476€ vs. 5,549€, p = 0.03 and model 2: 4,374€ vs. 5,309€, p = 0.02). In multivariate analysis costs were independently associated with length of stay and patient transfer to another hospital but not with support by a telestroke network.

Conclusion
Hospitals with support by a telestroke network are associated with improved qualified stroke care resulting in higher rates of IVT and stroke care according to OPS codes as well as lower rates of onward transfers. Costs per patient were independently associated with transfer rates and length of hospital stay.
Routine use of patient-reported experience and outcome measures for children and young people: a scoping review
Authors: Alarilla Anne , Terrell Katharine , Kelly Paula , Chesters Heather , Gibson Faith , Oldham Geralyn , Sell Debbie , Davies Gwyneth , Wray Jo 
Published: November 2024

Abstract
Background
Patient-reported outcome measures (PROMs) measure people’s views of their health status whereas patient-reported experience measures (PREMs) are questionnaires measuring perceptions of their experience whilst receiving healthcare. PROMs/PREMs have the potential to enable children and young people (CYP) to be involved in decisions about their care and improve the quality of their care but it is not clear how often PROMs/PREMs are incorporated as part of standard care of CYP in the hospital setting. The aims of this scoping review were to understand the extent of the literature and map available evidence on the use, benefits, barriers and facilitators of PROMs/PREMs as part of standard care and treatment of CYP in hospitals.

Methods
The Joanna Briggs Institute review process was used to map existing evidence on the use of PROMs/PREMs in routine care of CYP in different hospital settings worldwide. Key search terms were developed and Ovid (Emcare, Embase MEDLINE, APA PsychInfo), Scopus and Web of Science were searched. Data were analysed using frequency counts and basic content analysis for thematic mapping according to the research questions. We undertook an initial search in February 2021 and updated this in April 2023.

Results
The search yielded 68,004 studies, 388 were eligible for full text review and 172 met the inclusion criteria. PROMs were more commonly used than PREMs in routine care of CYP in hospitals; these were mostly collected using electronic collection and concentrated in specific specialities, settings, contexts and countries. The findings mapped the use of PROMs/PREMs, including how data are applied in clinical practice and used for service development, but this was not consistently reported. There are specific challenges in the implementation of PROMs/PREMs in routine care of CYP that need to be considered.

Conclusion
PROMs/PREMs have the potential to improve care for CYP in hospital settings contributing to different aspects of care. A better understanding of their use, how results can be applied in clinical practice and contribute to service development will enable meaningful employment. The popularity of electronically collected and captured PROMS/PREMs warrants further investigation to enable their meaningful use in routine care of CYP.

Systematic review registration
Not pre-registered.
Identification of immune-related mitochondrial metabolic disorder genes in septic shock using bioinformatics and machine learning
Authors: Cui Yu-Hui , Wu Chun-Rong , Huang Li-Ou , Xu Dan , Tang Jian-Guo 
Published: November 2024

Abstract
Purpose
Mitochondria are involved in septic shock and inflammatory response syndrome, which severely affects the life security of patients. It is necessary to recognize and explore the immune-mitochondrial genes in septic shock.

Methods
The GSE57065 dataset was acquired from the Gene Expression Omnibus (GEO) database and filtered by limma and the weighted correlation network analysis (WGCNA) to identify mitochondrial-related differentially expressed genes (MitoDEGs) in septic shock. The function of MitoDEGs was analyzed using the Gene Ontology (GO) analysis, Kyoto Encyclopedia of Genes and Genomes (KEGG), and Gene Set Enrichment Analysis (GSEA), respectively. The Protein-Protein Interaction (PPI) network composed of MitoDEGs was established using Cytoscape. Support Vector Machine Recursive Feature Elimination (SVM-RFE), Random Forest (RF), and Least Absolute Shrinkage and Selection Operator (LASSO) were used to identify diagnostic MitoDEGs, which were validated using receiver operating characteristic (ROC) analysis and Quantitative Real-time Reverse Transcription Polymerase Chain Reaction (qRT-PCR). Furthermore, the infiltration of immunocytes was analyzed using CIBERSORT, and the correlation between diagnostic MitoDEGs and immunocytes was explored using Spearman.

Results
A total of 44 MitoDEGs were filtered, and functional enrichment analysis showed they were associated with mitochondrial function, and the PPI network had 457 nodes and 547 edges. Four diagnostic genes, MitoDEGs, PGS1, C6orf136, THEM4, and EPHX2, were identified by three machine learning algorithms, and qRT-PCR results obtained similar expression levels as bioinformatics analysis. Furthermore, the diagnostic model constructed by the diagnostic genes had fine diagnostic efficacy. Immunocyte infiltration analysis showed that activated immunocytes were abundant and correlated with hub genes, with neutrophils accounting for the largest proportion in septic shock.

Conclusions
In this study, we recognized four immune-mitochondrial key genes (PGS1, C6orf136, THEM4, and EPHX2) in septic shock and designed a novel gene diagnosis model that provided a new and meaningful way for the diagnosis of septic shock.
Role of pentoxifylline in neonatal hypoxic ischaemic encephalopathy: a systematic review of animal studies
Authors: Wong Florence , Rath Chandra , Gowda Bhanu B. , Patole Sanjay 
Published: November 2024

AbstractWe systematically reviewed the evidence from animal studies assessing the effects of pentoxifylline on neonatal hypoxic-ischemic encephalopathy (HIE). The PubMed, EMBASE, EMCARE, MEDLINE, Cochrane Library, and Google Scholar databases were searched for randomized and quasi randomized controlled trials (RCTs) in December 2023 to determine the effects of pentoxifylline in animal models of HIE. The quality of the included studies was assessed via the SYRCLE risk of bias (ROB) tool. The certainty of evidence was assessed via the GRADE methodology. All seven included studies (n = 248) involved a rat HIE model in which pentoxifylline (25–150 mg/kg) was administered intraperitoneally. The majority had unclear ROB. All the studies reported a protective effect of pentoxifylline on HIE-induced organ injury. Mortality was comparable at pentoxifylline doses between 25 and 75 mg/kg but higher at 150 mg/kg than in the control group. Three studies reported macroscopic changes in HIE-affected organs. There was a significant reduction in cerebral infarction (40 and 75 mg/kg), hippocampal atrophy, and visible gut injury (60 mg/kg). A significantly lower number of Caspase 3 immunoreactive cells and necrotic cells were observed at the 60 mg/kg dose, whereas the 100 mg/kg dose had a deleterious effect. Three other studies reported significantly reduced levels of proinflammatory markers including IL-6 and TNF-alpha. Current evidence (with low uncertainty) from a rat model suggests that pentoxifylline has the potential to improve mortality and attenuate organ injury following HIE. Adequately powered, well-designed human RCTs are needed to confirm our findings.
O Canto da SereIA: inovação ou ilusão tecnológica?
Authors: Campagnolli Juliana Narj ara Libório , Carvalho Lilian Linhares de , Athayde Caroline Cunha de Oliveira , Farias Frank Douglas Cruz de 
Published: November 2024

Informamos que as notas de ensino dos casos possuem acesso restrito e são exclusivas para docentes e instrutores vinculados à uma instituição acadêmica. Saiba mais.
Cooperative trajectory planning: principles for human-machine system design on trajectory level
Authors: Schneider Julian , Varga Balint , Hohmann Sören 
Published: November 2024

Abstract
This paper explores cooperative trajectory planning approaches within the context of human-machine shared control. In shared control research, it is typically assumed that the human and the automation use the same reference trajectory to stabilize the coupled system. However, this assumption is often incorrect, as they usually follow different trajectories, causing control conflicts at the action level that have not been widely researched. To address this, it is logical to extend shared control concepts to include human-machine interaction at the trajectory-level before action execution, resulting in a unified reference trajectory for both human and automation. This paper begins with a literature overview on approaches of cooperative trajectory planning. It then presents an approach of finding a joint trajectory by modelling cooperative trajectory planning as an agreement process. A generally valid system structure is proposed for this purpose. Finally, it proposes concepts to implement cooperative trajectory planning as an agreement process.
Autonomous vehicle eHMI communication modalities: pedestrian preferences in crossing scenarios
Authors: Kühnlenz Kolja , Kühnlenz Barbara 
Published: November 2024

Abstract
This paper presents results from a study on the impact of negative attitudes towards robots on pedestrians’ needs for technological communication capabilities of autonomous vehicles and preferred communication modalities. Further, the amount of prior information on autonomous vehicles given to test persons is varied. The study is realized in terms of an imagination scenario. Results show a significant dependency of the demand for communication of autonomous vehicles with pedestrians on the extent of negative attitudes towards robots as well as a general demand for such communication capabilities. Interestingly, these findings are independent of the amount of prior information. Differences of preferred communication modalities with respect to negative attitudes or prior information are not found. The results of this study emphasize the importance of vehicle-pedestrian communication, particularly, using multi-modal interfaces in future autonomous driving technology.
Towards equitable shared control
Authors: Carlson Tom 
Published: November 2024

Abstract
Shared human-machine control systems are critical to realising assistive technologies that empower users to enhance their level of independence, and quality of life. In this paper, we present an overview of the state-of-the-art in equitable shared control for assistive robotics, drawing upon examples from our own work, applied to both smart wheelchair applications and the brain-machine interface domain. In particular, we focus on three themes: personalised control optimisation; understanding interactions with the environment; and supporting users to maintain control authority. Through these concepts we demonstrate the potential of equitable shared control systems and argue for future research into more dynamic policies that continue to support users as their needs evolve in the long-term.
Towards human capability estimation to enhance human-robot team performance
Authors: Mandischer Nils , Mikelsons Lars 
Published: November 2024

Abstract
Skilled labor shortage is a prominent challenge in the world of work. Meanwhile, age-related disabilities or injury lead to at least temporary performance limitations, which make people unfit to work. Consequently, even less workers are available. By employing human-robot teams, the performance of these people may be restored. This requires a good artificial understanding of the human’s capabilities, as generic robot behavior is not feasible with the highly individualized manifestations of disability. We present an approach that allows the robot to autonomously assess human capabilities based on standards from occupational medicine. The method does not only indicate the presence/absence of capabilities, but gives them a discrete rating. This allows the robot to better define its own behavior as a mixture of supportive actions based on gaps in the detailed capabilities.
Coffee shop-naming practices in Shanghai
Authors: Liao Cecily Ran , Chan Brian Hok-Shing 
Published: November 2024

Abstract
This study examines the naming practices of 303 coffee shop brand names in Shanghai from the perspectives of language choice, linguistic form, and semantic content, which are integral considerations in the naming process. All the collected names were categorized for various characteristics across these three dimensions. The results identify a number of characteristics of the coffee shop names, namely, the dominance of non-Chinese languages, widespread nonstandard forms, and various semantic content themes, including evocative names, emphasis on shop ambiance, business description, inclusion of subcultural elements, personalized names, and the use of positive descriptors and markers of geographical location. A content analysis of these names reveals that coffee shops are typically constructed as exotic, modern, trendy places that are popular among young customers. More notably, coffee shop naming is a trans-spatial practice that transforms the coffee shops into multirole sites and serves as a semiotic assemblage conveying special meaning to patrons; that is, the shops not only serve coffee and other food and beverages but may also provide an exotic cultural atmosphere in which customers receive emotional and spiritual sustenance, interact with friends, and even have surreal experiences.
The novel quadratic phase Fourier S-transform and associated uncertainty principles in the quaternion setting
Authors: Gargouri Ameni 
Published: November 2024

Abstract
In this article, we propose a novel integral transform coined as quaternion quadratic phase S-transform (Q-QPST), which is an extension of the quadratic phase S-transform and study the uncertainty principles associated with the Q-QPST. The Q-QPST possesses some desirable characteristics that are absent in conventional time-frequency transforms, especially for dealing with the time-varying quaternion-valued signals. First, we propose the definition of Q-QPST and then we explore some mathematical properties of the of quaternion Q-QPST, including the linearity, modulation, shift, orthogonality relation, and reconstruction formula. Second, we derive the associated Heisenberg’s uncertainty inequality and the corresponding logarithmic version for Q-QPST. Finally, an illustrative example and some potential applications of the Q-QPST are introduced.
Chlorite-induced porosity evolution in multi-source tight sandstone reservoirs: A case study of the Shaximiao Formation in western Sichuan Basin
Authors: Liang Qingshao , Chen Chunyu 
Published: November 2024

Abstract
The Jurassic Shaximiao Formation in the Sichuan Basin represents a significant tight gas reservoir, exhibiting marked permeability variations between the southern and northern regions of western Sichuan. This study examines the reservoir characteristics of the Shaximiao Formation, with a focus on the evolution of sandstone porosity under bidirectional provenance conditions and the underlying causes of permeability variations. The insights derived from this research are critical for the effective exploration and development of tight sandstone gas reservoirs. Analysis of core samples and thin sections through X-ray diffraction, cathodoluminescence, scanning electron microscopy, and electron probe microanalysis reveals that the southern region predominantly consists of feldspathic and lithic sandstone, whereas the northern region is characterized by feldspathic lithic and lithic feldspathic sandstone. The average porosity and permeability in the southern region are 10.52% and 0.1334 × 10−3 μm2, respectively, while in the northern region, they are 9.74% and 0.5262 × 10−3 μm2. The primary reservoir spaces are intergranular primary pores and intragranular secondary dissolution pores. Compaction significantly reduces porosity, particularly in the northern region (23.94%) compared to the southern region (22.75%), primarily due to the presence of chlorite coatings. Cementation further reduces porosity, whereas dissolution processes enhance it, elucidating the similar porosity values but differing permeabilities between the regions.
Albizia ferruginea (Guill. & Perr.) Benth. leaf abates deregulation of P53, IRS, HsD17β2, FTO, and CYP11a genes in polycystic ovarian syndrome rat
Authors: Ogunlakin Akingbolabo Daniel , Meruwoma Meek Oyinlola , Ihiasota Princewill Obinna , Ojo Oluwafemi Adeleke , Adegoke Adeyemi Abdullahi , Akinwumi Idayat Adeola , Ambali Owoola Azeezat , Awosola Oyindamola Esther , Sonibare Mubo Adeola 
Published: November 2024

Abstract

Objectives
This study investigated the potential ameliorative effects of Albizia ferruginea leaves on letrozole-induced PCOS in Wistar rats.

Methods
PCOS was induced in 25 female Wistar rats by administering letrozole (1 mg/kg), followed by treatment with 100 and 250 mg/kg body weight A. ferruginea leaf methanolic extract, as well as 1 mg/kg body weight of Clomiphene citrate as standard.

Results
An acute toxicity study revealed a toxic dosage of 2,000 mg/kg for the plant extract. The A. ferruginea extract exhibited potent hydroxyl radical scavenging ability. Treatment with A. ferruginea leaf extract improved the irregular estrus cycle and hormonal imbalance. Additionally, the extract administration led to decreased testosterone and increased estradiol levels when compared to the untreated PCOS rat. Furthermore, methanol extract normalizes the levels of insulin receptor substrate (IRS), type 2 17-HSD (HsD17β2), P53, 11a-hydroxylase/17,20-desmolase (CYP11a), and fat mass and obesity-associated (FTO), genes in the cervix of PCOS rats.

Conclusions
Overall, A. ferruginea demonstrated beneficial properties on polycystic ovary circumstances in rats, presenting its potential as a promising treatment for PCOS.
Der sogenannte ontologische Gottesbeweis – Anselms Argument im Vergleich mit Descartes
Authors: Ringleben Joachim 
Published: November 2024

Zusammenfassung
Die folgenden Ausführungen haben ihre stringente Begründung in einer detaillierten Interpretation von Anselms Proslogion, die ich im Jahre 2000 vorgelegt habe.1 Diese neue Lesart des Anselmschen Argumentes kann hier nicht in extenso wiedergegeben werden; ich werde aber ihre wesentlichen Ergebnisse heranziehen, um von da aus das Verhältnis zum Gottesbeweis des Descartes zu beleuchten.2