bluuebunny/crossref_metadata_2025_split huggingface dataset:
Site‐level risk predictors of peri‐implantitis: A retrospective analysis
Authors: Kumar Purnima S. , Dabdoub Shareef M. , Hegde Rachna , Ranganathan Nanditha , Mariotti Angelo 
Published: March 2018

AbstractAimThe goal of the present investigation was to identify site‐level factors that might allow prognostication of individual implants in partially dentate patients with multiple non‐splinted restorations.MethodsWe analysed clinical and radiographic characteristics of 222 non‐splinted single implants in function for at least 5 years in 86 partially dentate individuals at the time of functional loading and at follow‐up, with the outcome variable being peri‐implantitis. Principal component analysis identified factors contributing to greatest variability and linear discriminant analysis coupled with Random Forest Classifier used to identify risk predictors.ResultsAfter controlling for patient‐level factors, the following characteristics were associated with significantly increased risk for peri‐implantitis: Periodontal disease on adjoining teeth at the time of restoration (Odds Ratio (OR): 8.0), implant placement at a depth of 6 mm or more in relation to the CEJ of adjacent tooth (OR: 8.5), asymmetric prosthesis (OR: 4.3), history of tooth loss due to periodontitis (OR: 2.4) and a mean baseline plaque index of 1.6 or more (OR: 7.9).ConclusionsOur findings suggest that a system that incorporates both subject level and implant‐level factors is required to effectively prognosticate the success of individual implants.
Impact of age at menarche on obesity and glycemic control in Japanese patients with type 2 diabetes: Fukuoka Diabetes Registry
Authors: Sumi Akiko , Iwase Masanori , Nakamura Udai , Fujii Hiroki , Ohkuma Toshiaki , Ide Hitoshi , Jodai‐Kitamura Tamaki , Komorita Yuji , Yoshinari Masahito , Kitazono Takanari 
Published: March 2018

AbstractAims/IntroductionA younger age at menarche is associated with obesity and type 2 diabetes in adult life. The impact of early‐onset menarche on obesity and glycemic control in type 2 diabetes has not been investigated. The present study examined the relationship between age at menarche and obesity and glycemic control in type 2 diabetes.Materials and MethodsA total of 2,133 patients with type 2 diabetes aged ≥20 years were divided into groups according to age at menarche (≤11, 12, 13, 14 and ≥15 years). A retrospective cohort study examined the association of menarcheal age with adiposity and hemoglobin A1c.ResultsAge at menarche was inversely associated with body mass index (BMI) and abdominal circumference (P < 0.001). Each 1‐year decrease in age at menarche was associated with a 0.25‐kg/m2 and 0.6‐cm increase in BMI and abdominal circumference, respectively, using a multivariate‐adjusted model. Odds ratios for obesity and abdominal obesity significantly increased in participants with age at menarche ≤11 years after multivariable adjustments when age at menarche of 13 years was used as the reference (odds ratio 1.95, 95% CI 1.33–2.88, odds ratio 1.95, 95% CI 1.32–2.87, respectively). Younger age at menarche was significantly associated with higher hemoglobin A1c (P < 0.001); however, the association was not statistically significant after adjusting for BMI.ConclusionsAge at menarche of ≤11 years was associated with obesity after adjusting for confounding factors, and poor glycemic control associated with high BMI in type 2 diabetes. Age at menarche should be considered during clinical assessments.
Cross‐sectional survey of biosimilar insulin utilization in Asia: The Joint Asia Diabetes Evaluation Program
Authors: Gani Linsey , Lau Eric , Luk Andrea , Sobrepena Leorino , Tran Quang Khanh , Kesavadev Jothydev , Jia Weiping , Yu Weinan , Tsang Chiu Chi , Mukhopadhyay Monojitketan , Jha Sujeet , Sheu Wayne , Ho Yoon Kun , Nguyen Thy Khue , Ozaki Risa , So Wing Yee , Kwan Christine , Fu Amy W C , Mirasol Roberto , Phatak Sanjeev Ratnakar , Kumar Kanakatte Mylariah Prasanna , Aravind Sosale , Janakiraman Hari , Chan Juliana C N ,   the JADE Collaborative Study Group
Published: March 2018

AbstractAims/IntroductionBiosimilar insulin can reduce treatment costs, although the extent of its use is largely unknown. We examined biosimilar insulin use and its associations with the quality of glycemic control using the Joint Asia Diabetes Evaluation register.Materials and MethodsWe carried out a cross‐sectional analysis in 81,531 patients with type 1 and type 2 diabetes enrolled into the Joint Asia Diabetes Evaluation Program from 2007 to 2014. All insulin related terms are extracted from the Joint Asia Diabetes Evaluation portal, and compared clinical profiles between biosimilar and originator insulin users. Multivariate analysis was performed to assess the association of biosimilar insulin compared with originator insulin with dosage, glycated hemoglobin and hypoglycemia events.ResultsAmongst 81,531 patients, 20.5% (n = 16,738) were insulin‐treated. In four countries with high use of biosimilar insulin, 4.7% (n = 719) of insulin users (n = 10,197) were treated with biosimilar insulin (India n = 507, 70.3%; the Philippines n = 90, 12.5%; China n = 62, 8.6%; Vietnam n = 60, 8.3%). Biosimilar insulin users were younger and had higher body mass index, glycated hemoglobin, insulin dosage and more frequent hypoglycemia than originator insulin users. These associations were non‐significant after adjustment for confounders. Only age, college education, diabetes education, lipid control, physical activity and history of cardiovascular complications were independently associated with these quality measures.ConclusionsBiosimilar insulin use is not uncommon in Asia. Data exclusion due to incomplete capturing of brand names suggests possibly higher use. The multiple determinants of the quality of glycemic control call for establishment of prospective cohorts and diabetes registers to monitor the safety and efficacy of different brands of biosimilar insulin and their impacts on clinical outcomes.
Reproductive compatibility among Mexican populations of Anastrepha obliqua: theoretical and management implications
Authors: Rull J. , Tadeo E. , Lasa R. , Díaz‐Fleischer F. , Arredondo J. , Aluja M. 
Published: March 2018

AbstractThe fraterculus species group, composed of 34 species in the genus Anastrepha (Diptera: Tephritidae), includes the fraterculus cryptic species complex formed by eight reproductively isolated morphotypes. A previous study revealed six genetic mitochondrial types of Anastrepha obliqua, suggesting the existence of a second cryptic species complex. However, marked discrepancies between nuclear and mitochondrial loci rather suggest incomplete lineage sorting or introgression between A. obliqua and A. fraterculus. Such hybridization could nevertheless result in reproductive isolation, an outcome that could affect efficacy of area‐wide management for the most important pest of mangos in America. Two mitochondrial types occur in Mexico, and the limits of a third one, encompassing Central American populations, have not been clearly established. Here, we tested reproductive compatibility among three A. obliqua populations from the Pacific and a population from the Gulf of Mexico. No evidence of pre‐zygotic isolation was found. Flies from the Atlantic mated randomly for equal duration with individuals from three Pacific populations. Homotypic and heterotypic crosses produced similar numbers of eggs, with heterotypic crosses of Pacific males and Atlantic females hatching in lower proportions. Larvae of all cross types developed equally in mangos and exhibited no sex ratio distortion of hybrid F1. The three mitochondrial types identified in Mexico and Central America do not appear to be cryptic species and can be managed using one single strain for the sterile insect technique.
Duration of antibiotic treatment after endoscopic ultrasound‐guided drainage of walled‐off pancreatic necrosis not affecting outcomes
Authors: Sahar Nadav , Kozarek Richard A , Kanji Zaheer S , Chihara Shingo , Gan Seng Ian , Gluck Michael , Larsen Michael , Ross Andrew S , Irani Shayan 
Published: March 2018

AbstractBackground and AimAlthough society guidelines recommend a short course of antibiotics after drainage of walled‐off necrosis (WON), the exact duration is unclear.MethodsThis is a retrospective review of patients with no prior antibiotic exposure who underwent dual‐modality drainage (DMD) for sterile WON from 2008 to 2017. Patients were grouped into short duration (SD, ≤5 days) versus long duration (LD, >5 days). The main outcome was the frequency of recurrent infections.ResultsSixty‐one patients (25 in the SD group and 36 in the LD group) were included. Patients in the two groups had comparable age, comorbidities, and severity of disease (P = 0.89). Patients in the SD group were treated with antibiotics for a median of 3 days compared with 8.5 days in the LD group. There were no differences in recurrent febrile episodes within 30 days of procedure—44% of SD group versus 39% of LD (P = 0.69). There was also no difference in time to resolution of WON (64 days for both groups, P = 0.72) or duration of hospitalization post‐DMD (SD 7.7 days versus LD 7.5 days, P = 0.42). Three cases of Clostridium difficile colitis were observed in the LD group.ConclusionsLonger course of antibiotics seems to have similar outcomes compared with shorter courses in patients with WON treated with DMD. Prolonged‐course therapy may predispose to secondary infections like C. difficile colitis. A randomized controlled trial is needed to evaluate the role and duration of peri‐procedural antibiotics after drainage of sterile WON.
The relationship between process use and stage of change for sugary drinks
Authors: Cook A. S. , O'Leary F. , Allman‐Farinelli M. 
Published: March 2018

AbstractBackgroundDecreasing sugar‐sweetened beverage consumption may reduce obesity and obesity‐related diseases. To better understand what processes could facilitate a reduction in sugary beverage intake, we examined the relationship between stage‐of‐change and use of 10 processes of change. Secondarily, reliability of the measure was assessed.MethodsA cross‐sectional study was conducted, using a newly developed stage‐of‐change and process of change questionnaire. Participants (n = 105; male, n = 28) were aged between 18 and 60 years. A one‐way analysis of variance, with Tukey's and Benjamini–Hochberg post hoc tests, was used to compare process use by stages. Paired t‐tests were used to compare total cognitive and total behavioural process use within each stage. Cronbach's α coefficient and mean inter‐item correlation was used to assess internal consistency. Reliability of repeated items was examined using kappa.ResultsCognitive and behavioural processes were used more in the contemplation/preparation and maintenance stages than in precontemplation (all P < 0.05). Compared to precontemplation, process use was significantly higher in contemplation/preparation for five individual processes, action for four processes and maintenance for five processes. The use of dramatic relief and self liberation was lower in maintenance than contemplation/preparation. Across the stages, the use of eight of the 10 processes differed. The use of consciousness raising, self re‐evaluation and self liberation differed between stages more frequently than other processes.ConclusionsThe use of many processes differed by stage and could be incorporated into programmes aiming to assist adults in reducing their consumption of sugary drinks.
Prospective Environmental Analyses of Emerging Technology: A Critique, a Proposed Methodology, and a Case Study on Incremental Sheet Forming
Authors: Cooper Daniel R. , Gutowski Timothy G. 
Published: March 2018

SummaryProspective environmental assessment of emerging technology is necessary in order to inform designers of beneficial changes early in a technology's development, and policy makers looking to fund projects and nudge manufacturers toward the most sustainable application of a technology. Existing analyses often have shortcomings such as failing to consider the environmental impacts in all stages of a product's life cycle; implicitly assuming that the emerging technology will be cost‐effective wherever it is technically viable; and assuming optimistic application scenarios that discontinue long‐established trends in human behavior. In this article, we propose a new approach, complementary to the prospective and anticipatory life cycle assessment literature, addressing the above concerns and attempting to make sense of the large uncertainties inherent in such analyses by using distributions to model all the inputs. The paper focuses on emerging manufacturing technologies, such as incremental sheet forming (ISF), but the issues examined are also applicable to new end‐use products, such as autonomous vehicles. This paper makes use of approaches (such as Bass modeling and product cannibalization considerations) familiar to those in the business community who anticipate market diffusion of a new technology and the effect on existing technology sales. The proposed methodology is demonstrated by estimating the potential environmental impacts in the U.S. car industry by 2030 of an emerging double‐sided ISF process. Energy and cost models of ISF and drawing are used to estimate potential mean savings of around 100 TJprimary and 60 million U.S. dollars per year by 2030.
The association between gait and physical fitness in adults with intellectual disabilities
Authors: Oppewal A. , Hilgenkamp T. I. M. 
Published: March 2018

AbstractBackgroundGait deviations are often seen in adults with intellectual disabilities (ID). Their low physical fitness levels may be associated with these deviations. Understanding the impact of fitness on gait in this population is important for developing interventions to improve gait. In a cross‐sectional study, we assessed the association between multiple physical fitness components and spatiotemporal gait parameters in adults with ID.MethodGait characteristics of 31 adults (42.77 ± 16.70 years) with ID without Down syndrome were assessed with the GAITRite at comfortable (CS) and fast speed (FS), along with fitness assessments (body composition, muscular endurance, strength, balance, Short Physical Performance Battery).ResultsAt CS, adults with ID with higher BMI and/or waist circumference spent more time in double support. At FS, those with better muscular endurance took steps faster, those with better balance took bigger steps and strides and those with better Short Physical Performance Battery scores took bigger steps and strides at higher velocity.ConclusionsBody composition was mostly associated with gait at CS, while the other physical fitness components were mostly associated with gait at FS. Better fitness may therefore be more important in more challenging conditions. These insights are useful for developing interventions to improve gait in adults with ID.
Extremely thin layer plastification for focused‐ion beam scanning electron microscopy: an improved method to study cell surfaces and organelles of cultured cells
Authors: VAN DONSELAAR E.G. , DORRESTEIJN B. , POPOV‐ČELEKETIĆ D. , VAN DE WETERING W.J. , VERRIPS T.C. , BOEKHOUT T. , SCHNEIJDENBERG C.T.W.M. , XENAKI A.T. , VAN DER KRIFT T.P. , MÜLLER W.H. 
Published: March 2018

SummarySince the recent boost in the usage of electron microscopy in life‐science research, there is a great need for new methods. Recently minimal resin embedding methods have been successfully introduced in the sample preparation for focused‐ion beam scanning electron microscopy (FIB‐SEM). In these methods several possibilities are given to remove as much resin as possible from the surface of cultured cells or multicellular organisms. Here we introduce an alternative way in the minimal resin embedding method to remove excess of resin from two widely different cell types by the use of Mascotte filter paper. Our goal in correlative light and electron microscopic studies of immunogold‐labelled breast cancer SKBR3 cells was to visualise gold‐labelled HER2 plasma membrane proteins as well as the intracellular structures of flat and round cells. We found a significant difference (p < 0.001) in the number of gold particles of selected cells per 0.6 m2 cell surface: on average a flat cell contained 2.46 ± 1.98 gold particles, and a round cell 5.66 ± 2.92 gold particles. Moreover, there was a clear difference in the subcellular organisation of these two cells. The round SKBR3 cell contained many organelles, such as mitochondria, Golgi and endoplasmic reticulum, when compared with flat SKBR3 cells. Our next goal was to visualise crosswall associated organelles, septal pore caps, of Rhizoctonia solani fungal cells by the combined use of a heavy metal staining and our extremely thin layer plastification (ETLP) method. At low magnifications this resulted into easily finding septa which appeared as bright crosswalls in the back‐scattered electron mode in the scanning electron microscope. Then, a septum was selected for FIB‐SEM. Cross‐sectioned views clearly revealed the perforate septal pore cap of R. solani next to other structures, such as mitochondria, endoplasmic reticulum, lipid bodies, dolipore septum, and the pore channel. As the ETLP method was applied on two widely different cell types, the use of the ETLP method will be beneficial to correlative studies of other cell model systems and multicellular organisms.
Integrating the fundamentals of care framework in baccalaureate nursing education: An example from a nursing school in Denmark
Authors: Voldbjerg Siri Lygum , Laugesen Britt , Bahnsen Iben Bøgh , Jørgensen Lone , Sørensen Ingrid Maria , Grønkjær Mette , Sørensen Erik Elgaard 
Published: March 2018

Aims and objectivesTo describe and discuss the process of integrating the Fundamentals of Care framework in a baccalaureate nursing education at a School of Nursing in Denmark.BackgroundNursing education plays an essential role in educating nurses to work within healthcare systems in which a demanding workload on nurses results in fundamental nursing care being left undone. Newly graduated nurses often lack knowledge and skills to meet the challenges of delivering fundamental care in clinical practice. To develop nursing students’ understanding of fundamental nursing, the conceptual Fundamentals of Care framework has been integrated in nursing education at a School of Nursing in Denmark.Design and methodsDiscursive paper using an adjusted descriptive case study design for describing and discussing the process of integrating the conceptual Fundamentals of Care Framework in nursing education.ResultsThe process of integrating the Fundamentals of Care framework is illuminated through a description of the context, in which the process occurs including the faculty members, lectures, case‐based work and simulation laboratory in nursing education. Based on this description, opportunities such as supporting a holistic approach to an evidence‐based integrative patient care and challenges such as scepticism among the faculty are discussed.ConclusionIt is suggested how integration of Fundamentals of Care Framework in lectures, case‐based work and simulation laboratory can make fundamental nursing care more explicit in nursing education, support critical thinking and underline the relevance of evidence‐based practice. The process relies on a supportive context, a well‐informed and engaged faculty, and continuous reflections on how the conceptual framework can be integrated.Relevance to clinical practiceIntegrating the Fundamentals of Care framework can support nursing students’ critical thinking and reflection on what fundamental nursing care is and requires and eventually educate nurses in providing evidence‐based fundamental nursing care.
Role of p38 MAPK in disease relapse and therapeutic resistance by maintenance of cancer stem cells in head and neck squamous cell carcinoma
Authors: Roy Shomereeta , Roy Souvick , Kar Madhabananda , Padhi Swatishree , Saha Arka , Anuja Kumari , Banerjee Birendranath 
Published: March 2018

AimThis study aimed to investigate the role of p38 MAPK in maintenance of cancer stem cell (CSC) phenotype, therapy resistance, and DNA damage repair and response in head and neck squamous cell carcinoma (HNSCC).MethodsIn this study, 104 HNSCC patients were included. Western blot, immunohistochemistry, and qPCR analysis were performed to investigate the expression level of p‐p38 and CSC markers in cut margin and tumor area of HNSCC patients. The expression level of p‐p38 and CSC markers was also evaluated in HNSCC cells with or without p38 inhibitor. Chemoresistance, wound healing capacity, and multicellular tumor spheroids (MCTS) formation capacity were evaluated in HNSCC‐derived cell lines with or without p38 inhibitor. In addition, DNA damage response and repair capacities were also evaluated in HNSCC cells after p38 inhibition using alkaline comet assay and γ‐H2AX immunostaining.ResultWe observed that recurrence could be associated with upregulated status of p‐p38 and p38α gene in cut margin area of HNSCC patients as compared to tumor region. p38‐inhibited cells showed significantly reduced expression of CSC markers, chemosensitivity toward cisplatin, reduced migration potential, and sphere‐forming ability along with increased apoptotic population after treatment with increasing concentration of cisplatin. p38‐inhibited cells also exhibited significantly increased comet olive tail moment and accumulation of γ‐H2AX, demonstrating increased DNA damage.ConclusionThis study demonstrated that p38 MAPK activation may play a role in therapeutic resistance and disease relapse in HNSCC by maintenance of CSCs phenotype.
Ginsenoside Rb1 inhibits autophagy through regulation of Rho/ROCK and PI3K/mTOR pathways in a pressure-overload heart failure rat model
Authors: Yang Tianrui , Miao Yunbo , Zhang Tong , Mu Ninghui , Ruan Libo , Duan Jinlan , Zhu Ying , Zhang Rongping 
Published: March 2018

Abstract

Objective
This study was designed to explore the relationship between ginsenoside Rb1 (Grb1) and high-load heart failure (HF) in rats.

Methods
The parameters of cardiac systolic function (left ventricular posterior wall thickness (LVPWT), left ventricular internal diastolic diameter (LVID), fraction shortening (FS) and mitral valves (MVs)) of rat hearts in each group were inspected by echocardiogram. The expressions of rat myocardial contractile proteins, autophagy-related proteins and the activation of Rho/ROCK and PI3K/mTOR pathways were detected by Western blot.

Key findings
LVPWT, FS, MVs and the expression of myocardial contractile proteins α-MHC, apoptosis-related proteins Bcl-2 and signalling pathway involved proteins pAkt and mTOR were significantly reduced in the HF, HF+5 mg/kg Grb1 (HF+Grb1-5) and HF+Grb1+arachidonic acid (AA) groups with LVID, β-MHC, cell apoptosis, cell autophagy and Rho/ROCK significantly increased compared with the control group, of which the tendency was contrary to the HF+20 mg/kg Grb1 (HF+Grb1-20) group compared with the HF group (P &lt; 0.05). In the HF+Grb1+AA group, there was no significant change in the above indexes compared with the HF group.

Conclusions
The results indicated that Grb1 can exert anti-HF function by inhibiting cardiomyocyte autophagy of rats through regulation of Rho/ROCK and PI3K/mTOR pathways.