bluuebunny/crossref_metadata_2025_split huggingface dataset:
Apoyo diagnóstico con ecografía en papilomas plantares: caso clínico
Authors: Grande del Arco Jessica 
Published: October 2019

Las verrugas cutáneas son tumores intraepidérmicos benignos de la piel con una variedad de manifestaciones incluyendo verrugas comunes (verrucae vulgaris), verrugas palmar y plantar (verrugas palmares y plantares), verrugas en mosaico, verrugas planas (verrugas planas) generalmente diagnosticado por su apariencia clínica aunque el diagnóstico definitivo depende del examen histopatológico.
La ecografía puede definir su extensión, ubicaciones exactas y patrones de flujo sanguíneo siendo extremadamente útil en casos difíciles, especialmente cuando los síntomas como el dolor persisten en el tiempo. También puede dar relevancia información prequirúrgica y, finalmente, puede proporcionar ideas importantes sobre las condiciones asociadas del pie.
Group Work as Applied to Organizations/Systems
Authors: Levine Talia Bar-Yoseph 
Published: October 2019

Abstract
In this reflective piece, the author gives an extended case presentation of Gestalt organizational work, wherein a business leader takes his organization through a period of difficult change. She demonstrates how the Gestalt “philosophy of being” can be applied as a tool for building teams in real-world situations, as well as help those teams cope with and adapt to change. The dialogical stance is shown to promote trust, resilience, and awareness in leaders and their teams undergoing organizational transformation. This case presentation manifests how seemingly inhuman and impossible situations can be managed compassionately through the application of sound Gestalt principles and methods.
Practice Patterns in Reporting Tertiary Grades at Radical Prostatectomy: Survey of a Large Group of Experienced Urologic Pathologists
Authors: Fine Samson W. , Meisels Debra L. , Vickers Andrew J. , Al-Ahmadie Hikmat , Chen Ying-Bei , Gopalan Anuradha , Sirintrapun S. Joseph , Tickoo Satish K. , Reuter Victor E. 
Published: October 2019

Context.—In prostate cancer, “tertiary” higher-grade patterns (TPs) have been associated with biochemical recurrence after radical prostatectomy.Objective.—To determine variation regarding definition and application of TPs.Design.—Online survey regarding TPs in a range of grading scenarios circulated to 105 experienced urologic pathologists.Results.—Among 95 respondents, 40 of 95 (42%) defined TPs as “third most common pattern” and 55 (58%) as “minor pattern/less than 5% of tumor.” In a tumor with pattern 3 and less than 5% pattern 4, of the 95 respondents, 35 (37%) assigned 3 + 3 = 6 with TP4, while 56 (59%) assigned 3 + 4 = 7. In a tumor with pattern 4 and less than 5% pattern 5, of the 95 respondents, 51 (54%) assigned 4 + 4 = 8 with TP5, while 43 (45%) assigned 4 + 5 = 9. Six scenarios were presented in which the order of most common patterns was 3, 4, and 5 (Group 1) or 4, 3, and 5 (Group 2) with varying percentages. In both groups, when pattern 5 was less than 5%, we found that 98% and 93% of respondents would assign 3 + 4 = 7 or 4 + 3 = 7 with TP5. In scenarios with 15% or 25% pattern 5, most respondents (70% and 80%, respectively) would include pattern 5 as the secondary grade, that is, 3 + 5 = 8 (Group 1) or 4 + 5 = 9 (Group 2). For 85 of 95 (89%), a TP would not impact Grade Group assignment.Conclusions.—This survey highlights substantial variation in practice patterns regarding definition and application of “tertiary” grading in radical prostatectomy specimens. High consistency was observed in 3 + 4 = 7/4 + 3 = 7 scenarios with truly minor pattern 5. These findings should inform future studies assessing the standardization and predictive value of “tertiary” patterns.
Effect of canopy cover on development of cedar (<i>Cedrela fissilis</i>) and aspects of damage caused by <i>Hypsipyla grandella</i> in agroforestry system
Authors: Borges Rafael , Boff Mari Inês Carissimi , Blassioni-Moraes Maria Carolina , Biscaro-Borges Camila , Mantovani Adelar 
Published: October 2019

Cedrela fissilis (Vell.) is an important wood species, native to South America. It is appreciated for its physical characteristics and, therefore, its native specimens are overexploited.Commercial cultivation initiatives have been continuously flawed as a result of the damage caused by mahogany shoot borer Hypsipyla grandella (Zeller, 1848).Planting under shaded sites has been one of the management methods used to reduce insect attacks. However, the reason why mahogany shoot borer does not attack shaded plants as often is still unknown. Therefore, the aim of this research was to find cultivation parameters that could combine proper plant development and low rate ofattacks by Hypsipyla grandella.For this purpose, increases in height and shoot diameter of cedar seedlings, planted in agroforestry systems, were monitored for the two first years. Three canopy cover rates, namely, 0-20%, 20-40% and 40-60%, were tested for plant development andfrequency of attacks byHypsipyla grandella. The adult population of the insect was monitored with semiochemicals throughout the experimental period, and two pheromonal blends and one food bait were tested. Field results showed that one of the pheromone blends was efficient in identifying small variations in the population of adult specimens. Regarding to the plant development, the treatment with the highest cover rate showed the lowest parameters compared to the intermediate cover. The frequency of attacks byHypsipyla grandella was greater in the treatment with the lowest cover (0-20%).The results suggest that in canopy cover, ranging from 20 to 40%, good rates of initial development of plants can be combined with low frequency of attack by Hypsipyla grandella.
HPLC-UV Standard Phenolic Constituents of African Bush Mango (Irvingia gabonensis) and Molecular Docking on Polyphenol Oxidases
Authors: Adeseko Catherine Joke , Sanni David Morakinyo , Salawu Sule Ola , Kade Ige Joseph , Fatoki Toluwase Hezekiah 
Published: October 2019

Introduction: Irvingia gabonensis belongs to the Irvingiaceae plant family and commonly known as the African bush mango, wild mango, Dika nut and Manguier sauvage. The fruits of I. gabonensis are edible and their use in traditional medicine has been reported for the treatment of diabetes, diarrhea, wound ulcer, hepatic disorder, microbial infections, and inflammatory pains.
Aim: This study aimed to identify the standard phenolic contents of I. gabonensis fruit pulp and peel extracts and investigate the bind energy on polyphenol oxidase in order to know why browning of I. gabonensis fruit is often rapidly occur and how to prevent it with suitable inhibitor in an industrial processing.
Results: The phenolics that were identified include ellagic acid, cinnamic acid, gallic acid, 3-friedelanone, lupeol, kaempferol, quercetin, alpha-curcumene and zingiberene. The two PPO from Solanum lycopersicum (PDB ID: 6HQI) and Mangifera indica (PDB: D2XZ13_model) have different binding energies across the ligands with highest score by 3-friedelanone (-14.3 and -16.1 kcal/mol respectively), followed by lupeol (-13.9 and -14.6 kcal/mol respectively). The differences in the binding energies across the plant PPOs could be due to variation in the amino acid composition and more importantly the amino acid residues that participate in the catalytic and allosteric activities
Conclusion: This study has shown the reason behind rapid browning that usually occur in I. gabonensis and more importantly, the need for effective edible inhibitors of PPO.
Anti-virulence Activity of Three Medicinal Plants: Cassia occidentalis L., Crossopteryx febrifuga (Afzel ex G. Don) Benth. and Zanthoxylum zanthoxyloides (Lam) Zep. and Timl
Authors: Ouedraogo Vincent , Compaoré Eli , Rouamba Ablassé , Compaoré Moussa , Kiendrebeogo Martin 
Published: October 2019

Aims: This current study was designated to assess the ability of Cassia occidentalis, Crossopteryx febrifuga and Zanthoxylum zanthoxyloides traditionally used for the treatment of infectious diseases, to reduce the production of virulence factors.
Place and Duration of Study: The study was conducted at the Laboratory of Applied Biochemistry and Chemistry (LABIOCA), University Ouaga 1 Pr Joseph KI-ZERBO between September 2018 to January 2019.
Methodology: Methanol extracts from C. occidentalis (leaves and stem), C. febrifuga (leaves and stem) and Z. zanthoxyloides (Stem bark) were used for the investigations. The reporter strain Pseudomonas aeruginosa PAO1 was used to measure the impact of extracts on elastase and pyocyanin production. Antioxidant activity was measured through 2,2-diphenyl-1-picrylhydrazyl (DPPH) assays.
Results: All extracts at the concentration of 100 µg/mL inhibited significantly the production of pyocyanin without affect negatively the growth of P. aeruginosa PAO1 with a reduction of 39%, 52% and 28% respectively for C. occidentalis, C. febrifuga and Z. zanthoxyloides. C. febrifuga showed the highest inhibition level on the production of elastase with a rate of 48%. The results demonstrated varying level of reduction of pyocyanin and elastase production in the reporter strain. Moreover, the antioxidant polyphenols evidenced are capable to reduce the oxidative stress induced by pyocyanin.
Conclusion: The antioxidant and anti-virulence properties of these medicinal plants could justify their traditional use in the treatment of infectious diseases.
Volatile Compounds Are Involved in Cellular Crosstalk and Upregulation
Authors: Serasanambati Mamatha , Broza Yoav Y. , Haick Hossam 
Published: October 2019

AbstractCell–cell cross talk is of great importance in cancer research due to its major role in proliferation, differentiation, migration, and influence on the apoptotic pathway. Different cell–cell communication mechanisms have come mainly from proteomic and genomic approaches. In this paper, a new route is reported for cross talk between cancer cells that occurs, even when they are far away from each other. Single‐cell and culture analysis shows that upregulation of cancer cells emits hundreds of volatile organic compounds (VOCs) into their headspace. Part of the VOCs remains without any change, disregarding the biological environment around it. The other part of the VOCs is exchanged between monocultures of the cells as well as between co‐cultures of the cells with no physical contact between them, leading to different changes in growth than when left on their own. The chemical nature and composition of these VOCs have been determined and are discussed herein. Cell‐to‐cell cross talk has the advantage of being suitable for transfer/diffusion over relatively long distances. It would thus be expected to serve as a shuttling pad toward the development of advanced approaches that could enable very early detection of cancer and/or monitoring of metastasis and related cancer therapy.
Advanced Antiscaling Interfacial Materials toward Highly Efficient Heat Energy Transfer
Authors: Meng Jingxin , Wang Shutao 
Published: October 2019

AbstractThe energy problem has been a matter of some concern worldwide over the past 20 years. On the opposite side of energy production, energy loss is another crucial problem of current energy due to the low efficiency of heat transfer from scale deposition. However, less attention has been paid on the further development of advanced antiscaling interfacial materials, which may provide promising ways to save energy by reducing scale fouling. Herein, the development of antiscaling strategies is summarized from the basic theories and fabrication methods to antiscaling interfacial materials with potential applications. First, the mechanism of scale formation and the corresponding effect on thermal conductivity are introduced. Second, the typical fabrication approaches of antiscaling interfacial materials are briefly described. Finally, the performance, potential applications, future challenges, and opportunities of the advanced antiscaling interfacial materials are comprehensively discussed.
Visualization of UV by Nanopatterned Down‐Shifting Materials Mimicking Human Retinal Cone Cells
Authors: Sohn Wonbae , Park Heeyeon , Yoo Gang Yeol , Lee Chiho , Park Sungnam , Kim Woong 
Published: October 2019

AbstractThe conversion of invisible ultraviolet (UV) light to visible light by down‐shifting (DS) materials has a variety of important applications in the fields of optoelectronics and photonics. The ability to control emission colors as a function of the wavelength of incident UV light would significantly advance scientific research and technological applications. A novel strategy for UV visualization is demonstrated that employs nanoimprint lithography combined with a sol–gel process. The principles of trichromacy of human vision are applied; three DS materials sensitive to three different ranges of UV light are nanopatterned to mimic the three types of cone cells in the human retina. Each DS material then emits a distinctive color that can be recognized by each type of cone cells for visualization. The nanopatterned structure significantly intensifies the light emission by Mie scattering and spatially separates the three DS materials, thereby minimizing unwanted optical interference among them. The deliberately designed triple‐nanopatterned DS materials exhibit various emission colors ranging from green, to orange, to pink depending on the wavelength of the incident UV light. The current work would contribute to the development of novel strategies for multicolor tunable emission that may lead to innovative applications.
Layered P2‐Type K0.44Ni0.22Mn0.78O2 as a High‐Performance Cathode for Potassium‐Ion Batteries
Authors: Zhang Xinyuan , Yang Yubo , Qu Xianlin , Wei Zhixuan , Sun Ge , Zheng Kun , Yu Haijun , Du Fei 
Published: October 2019

AbstractPotassium‐ion batteries (KIBs) are emerging as one of the most promising candidates for large‐scale energy storage owing to the natural abundance of the materials required for their fabrication and the fact that their intercalation mechanism is identical to that of lithium‐ion batteries. However, the larger ionic radius of K+ is likely to induce larger volume expansion and sluggish kinetics, resulting in low specific capacity and unsatisfactory cycle stability. A new Ni/Mn‐based layered oxide, P2‐type K0.44Ni0.22Mn0.78O2, is designed and synthesized. A cathode designed using this material delivers a high specific capacity of 125.5 mAh g−1 at 10 mA g−1, good cycle stability with capacity retention of 67% over 500 cycles and fast kinetic properties. In situ X‐ray diffraction recorded for the initial two cycles reveals single solid‐solution processes under P2‐type framework with small volume change of 1.5%. Moreover, a cathode electrolyte interphase layer is observed on the surface of the electrode after cycling with possible components of K2CO3, RCO2K, KOR, KF, etc. A full cell using K0.44Ni0.22Mn0.78O2 as the cathode and soft carbon as the anode also exhibits exceptional performance, with capacity retention of 90% over 500 cycles as well as superior rate performance. These findings suggest P2‐K0.44Ni0.22Mn0.78O2 is a promising candidate as a high‐performance cathode for KIBs.
Sensitive and Ultrabroadband Phototransistor Based on Two‐Dimensional Bi2O2Se Nanosheets
Authors: Tong Tong , Chen Yunfeng , Qin Shuchao , Li Weisheng , Zhang Junran , Zhu Chunhui , Zhang Chunchen , Yuan Xiao , Chen Xiaoqing , Nie Zhonghui , Wang Xinran , Hu Weida , Wang Fengqiu , Liu Wenqing , Wang Peng , Wang Xuefeng , Zhang Rong , Xu Yongbing 
Published: October 2019

AbstractBi2O2Se, a high‐mobility and air‐stable 2D material, has attracted substantial attention for application in integrated logic electronics and optoelectronics. However, achieving an overall high performance over a wide spectral range for Bi2O2Se‐based devices remains a challenge. A broadband phototransistor with high photoresponsivity (R) is reported that comprises high‐quality large‐area (≈180 µm) Bi2O2Se nanosheets synthesized via a modified chemical vapor deposition method with a face‐down configuration. The device covers the ultraviolet (UV), visible (Vis), and near‐infrared (NIR) wavelength ranges (360–1800 nm) at room temperature, exhibiting a maximum R of 108 696 A W−1 at 360 nm. Upon illumination at 405 nm, the external quantum efficiency, R, and detectivity (D*) of the device reach up to 1.5 × 107%, 50055 A W−1, and 8.2 × 1012 Jones, respectively, which is attributable to a combination of the photogating, photovoltaic, and photothermal effects. The devices reach a −3 dB bandwidth of 5.4 kHz, accounting for a fast rise time (τrise) of 32 µs. The high sensitivity, fast response time, and environmental stability achieved simultaneously in these 2D Bi2O2Se phototransistors are promising for high‐quality UV and IR imaging applications.
Validating a Predictive Structure–Property Relationship by Discovery of Novel Polymers which Reduce Bacterial Biofilm Formation
Authors: Dundas Adam A. , Sanni Olutoba , Dubern Jean‐Frédéric , Dimitrakis Georgios , Hook Andrew L. , Irvine Derek J. , Williams Paul , Alexander Morgan R. 
Published: October 2019

AbstractSynthetic materials are an everyday component of modern healthcare yet often fail routinely as a consequence of medical‐device‐centered infections. The incidence rate for catheter‐associated urinary tract infections is between 3% and 7% for each day of use, which means that infection is inevitable when resident for sufficient time. The O'Neill Review on antimicrobial resistance estimates that, left unchecked, ten million people will die annually from drug‐resistant infections by 2050. Development of biomaterials resistant to bacterial colonization can play an important role in reducing device‐associated infections. However, rational design of new biomaterials is hindered by the lack of quantitative structure–activity relationships (QSARs). Here, the development of a predictive QSAR is reported for bacterial biofilm formation on a range of polymers, using calculated molecular descriptors of monomer units to discover and exemplify novel, biofilm‐resistant (meth‐)acrylate‐based polymers. These predictions are validated successfully by the synthesis of new monomers which are polymerized to create coatings found to be resistant to biofilm formation by six different bacterial pathogens: Pseudomonas aeruginosa, Proteus mirabilis, Enterococcus faecalis, Klebsiella pneumoniae, Escherichia coli, and Staphylococcus aureus.
Dopant Segregation Boosting High‐Voltage Cyclability of Layered Cathode for Sodium Ion Batteries
Authors: Wang Kuan , Wan Hui , Yan Pengfei , Chen Xiao , Fu Junjie , Liu Zhixiao , Deng Huiqiu , Gao Fei , Sui Manling 
Published: October 2019

AbstractAs a widely used approach to modify a material's bulk properties, doping can effectively improve electrochemical properties and structural stability of various cathodes for rechargeable batteries, which usually empirically favors a uniform distribution of dopants. It is reported that dopant aggregation effectively boosts the cyclability of a Mg‐doped P2‐type layered cathode (Na0.67Ni0.33Mn0.67O2). Experimental characterization and calculation consistently reveal that randomly distributed Mg dopants tend to segregate into the Na‐layer during high‐voltage cycling, leading to the formation of high‐density precipitates. Intriguingly, such Mg‐enriched precipitates, acting as 3D network pillars, can further enhance a material's mechanical strength, suppress cracking, and consequently benefit cyclability. This work not only deepens the understanding on dopant evolution but also offers a conceptually new approach by utilizing precipitation strengthening design to counter cracking related degradation and improve high‐voltage cyclability of layered cathodes.
A Dynamic 3D Tumor Spheroid Chip Enables More Accurate Nanomedicine Uptake Evaluation
Authors: Zhuang Jialang , Zhang Jie , Wu Minhao , Zhang Yuanqing 
Published: October 2019

AbstractNanomedicine has brought great advances for drug delivery by improving the safety and efficacy of pharmaceuticals. However, many nanomaterials showing good distribution property in vitro often display poor cellular uptake during in vivo administration. Current cellular uptake research models are mainly based on the traditional 2D culture system, which is a single layer and static system, thus the results cannot accurately reflect the distribution of nanoparticles (NPs) in vivo. In the present study, a multiple tumor culture chip (MTC‐chip) is constructed to mimic solid tumor and dynamic fluid transport, in order to better study NPs penetration in vitro. Cellular uptake of mesoporous silica particles (MSNs) is evaluated using the 3D tumor spheroids on chip, and it is found that: 1) continuous administration results in larger MSNs penetration than transient administration at the same dose; 2) the size effect on cellular uptake is less significant than reported by previous in vitro studies; and 3) pretreatment with hyaluronidase (HAase) enhances the tumor penetration of large‐size MSNs.
High‐Resolution 3D Printing of Freeform, Transparent Displays in Ambient Air
Authors: An Hyeon Seok , Park Young‐Geun , Kim Kukjoo , Nam Yun Seok , Song Myoung Hoon , Park Jang‐Ung 
Published: October 2019

AbstractDirect 3D printing technologies to produce 3D optoelectronic architectures have been explored extensively over the last several years. Although commercially available 3D printing techniques are useful for many applications, their limits in printable materials, printing resolutions, or processing temperatures are significant challenges for structural optoelectronics in achieving fully 3D‐printed devices on 3D mechanical frames. Herein, the production of active optoelectronic devices with various form factors using a hybrid 3D printing process in ambient air is reported. This hybrid 3D printing system, which combines digital light processing for printing 3D mechanical architectures and a successive electrohydrodynamic jet for directly printing transparent pixels of organic light‐emitting diodes at room temperature, can create high‐resolution, transparent displays embedded inside arbitrarily shaped, 3D architectures in air. Also, the demonstration of a 3D‐printed, eyeglass‐type display for a wireless, augmented reality system is an example of another application. These results represent substantial progress in the development of next‐generation, freeform optoelectronics.
Genotype x Environmental Effects on Yielding Ability and Seed Chemical Composition of Industrial Hemp (Cannabis sativa L.) Varieties Grown in North Dakota, USA
Authors: Lan Yang , Zha Fengchao , Peckrul Allen , Hanson Bryan , Johnson Burton , Rao Jiajia , Chen Bingcan 
Published: October 2019

AbstractThe influence of growing conditions in North Dakota on grain yield and seed composition was evaluated for industrial hemp varieties (Cannabis sativa L.) grown in North Dakota, USA. Average grain yield across varieties was 2138 kg ha−1. Crude protein content of undehulled industrial hemp flour from 10 varieties ranged from 32.7% to 35.9%; and oil content ranged from 24.3% to 28.1%. All industrial hemp flours were excellent natural sources of iron (46.7%), manganese (169.1%), copper (29.0%), zinc (28.2%), phosphorus (41.0%), and magnesium (33.7%) on a per serving basis (30 g per serving) for percent recommended daily intake (% RDI). Oils from most of the varieties differed significantly for the fatty acid (FA) profile. The n6/n3 ratio ranged from 3.2 to 5.1. Principal component analysis (PCA) suggested that CFX‐2 and CRS‐1 grew well in North Dakota based on grain yield, flour, and oil quality. In this study, the chemical composition of flour was not influenced by crop year; but crop year did effect the nutritional mineral composition. These results may have important implications for the use of industrial hemp in food applications.