bluuebunny/crossref_metadata_2025_split huggingface dataset:
Synthesis of Isoquinoline from Benzimidates via Ru(II)‐Catalyzed C–H Alkylation/Annulations with Diazo Compounds
Authors: Borah Gongutri , Ramaiah Danaboyina , Patel Pitambar 
Published: October 2018

AbstractA Ru(II)‐catalyzed C–H alkylation/annulations of benzimidate with diazo compounds have been developed for the synthesis of functionalized isoquinoline. The reaction proceeds under mild condition and exhibit broad functional group tolerance. This strategy also provides a direct approach to isoquinolines and 3,4‐dihydrophenanthridin synthesis. Moreover, Ru(II)‐catalyzed C−H carbenoid functionalization of benzimidate with diazodiester is also demonstrated.
“Non‐Naked” Gold with Glucose Oxidase‐Like Activity: A Nanozyme for Tandem Catalysis
Authors: Zhang Haijiao , Liang Xin , Han Lei , Li Feng 
Published: October 2018

AbstractIt has been widely reported that “naked” gold nanoparticles (Au NPs) without protectors have glucose oxidase (GOx)‐like activity, and the use of protectors can inhibit the GOx‐like activity. Here, “non‐naked” Au NPs with GOx‐like activity are synthesized by using protein as protector. Although “naked” Au NPs have peroxidase‐like activity and GOx‐like activity, the optimal pH ranges of the both activities are obviously different. Fortunately, as‐synthesized “non‐naked” Au NPs show the dual enzyme‐like activities at the same pH. So, “non‐naked” Au NPs can be described as “tandem nanozyme.” As another bonus, the participation of protein protector can stabilize the GOx‐like activity and make Au NPs modifiable. Even though Au NPs are connected with graphene oxide (GO), the GOx‐like activity is still not changed. Further, Au NPs‐GO nanocomposites are applied on the one‐pot nonenzymatic glucose colorimetric detection. The “non‐naked” gold not only broadens the species of tandem nanozymes, but also facilitates the functionalization of nanozymes, which is promising for immunoassay, biosensor, and medical treatment.
Carbon‐Carbon and Carbon‐Heteroatom Bond Formation Reactions Using Unsaturated Carbon Compounds
Authors: Sultan Shaista , Shah Bhahwal Ali 
Published: October 2018

AbstractThe carbon‐carbon and carbon‐heteroatom bond formation reactions are considered as a fundamental tool in synthetic organic chemistry. They have been effectively utilized in the synthesis of medicinally significant molecules, agrochemicals and valuable compounds in material sciences. This has been primarily enabled by highly efficient protocols arising from divergent mechanistic pathways. In this personal account, we aim to discuss some recent advances in carbon‐carbon or carbon‐heteroatom bond formation reactions to which our group has actively contributed. More specifically, this record focuses on the use of unsaturated carbon compounds for the construction of C−C and C−X bonds.
Perfluorooctanoic acid disrupts gap junction intercellular communication and induces reactive oxygen species formation and apoptosis in mouse ovaries
Authors: López‐Arellano Patricia , López‐Arellano Keila , Luna Jaquelinne , Flores Diana , Jiménez‐Salazar Javier , Gavia Graciela , Teteltitla Mario , Rodríguez Juan José , Domínguez Alejandro , Casas Eduardo , Bahena Ivan , Betancourt Miguel , González Cristina , Ducolomb Yvonne , Bonilla Edmundo 
Published: October 2018

AbstractPerfluorooctanoic acid (PFOA) is a member of the perfluoroalkyl acid family of compounds. Due to the presence of strong carbon–fluorine bonds, it is practically nonbiodegradable and highly persistent in the environment. PFOA has been detected in the follicular fluid of women, and positively associated with reduced fecundability and infertility. However, there are no reports concerning the experimental evaluation of PFOA on oocyte toxicity in mammals. The aim of the present study was to determine if PFOA is able to induce oxidative stress in fetal ovaries and cause apoptosis in oocytes in vitro. In addition, since inhibition of the gap junction intercellular communication (GJIC) by PFOA has been demonstrated in liver cells in vivo and in vitro, the effect of PFOA on the GJIC between the oocyte and its supportive cumulus cells was studied. Results show that PFOA induced oocyte apoptosis and necrosis in vitro (medium lethal concentration, LC50 = 112.8 μM), as evaluated with Annexin‐V‐Alexa 508 in combination with BOBO‐1 staining. Reactive oxygen species (ROS) levels, as assessed by DCFH‐DA, increased significantly in fetal ovaries exposed to ¼ LC50 (28.2 μM, a noncytotoxic and relevant occupational exposure concentration) and LC50 PFOA ex vivo. This perfluorinated compound also caused the blockage of GJIC in cumulus cells‐oocyte complexes (COCs) obtained from female mice exposed in vivo, as evaluated by calcein transfer from cumulus cells to the oocyte. The ability of PFOA of disrupting the GJIC in COCs, generating ROS in the fetal ovary and causing apoptosis and necrosis in mammal's oocytes, might account for the reported association between increasing maternal plasma concentrations of PFOA with reduced fertility in women.
The phenomenon of lipid metabolism “cut” mutants
Authors: Zach Róbert , Převorovský Martin 
Published: October 2018

AbstractEvery cell cycle iteration culminates with the resolution of a mitotic nucleus into a pair of daughter nuclei, which are distributed between the two daughter cells. In the fission yeast Schizosaccharomyces pombe, the faithful division of a mitotic nucleus depends on unperturbed lipogenesis. Upon genetically or chemically induced perturbation of lipid anabolism, S. pombe cells fail to separate the two daughter nuclei and subsequently initiate lethal cytokinesis resulting in the so‐called “cut” terminal phenotype. Evidence supporting a critical role of lipid biogenesis in successful mitosis in S. pombe has been accumulating for almost two decades, but the exact mechanism explaining the reported observations had been elusive. Recently, several studies established a functional link between biosynthesis of structural phospholipids, nuclear membrane growth, and the fidelity of “closed” mitosis in S. pombe. These novel insights suggest a mechanistic explanation for the mitotic defects characteristic for some S. pombe mutants deficient in lipid anabolism and extend our knowledge of metabolic modulation within the context of the cell cycle. In this review, we cover the essential role of lipogenesis in “closed” mitosis, focusing mainly on S. pombe as a model system.
Dynamic stress intensity factors of an interfacial crack in orthotropic elastic strips under impact loading conditions
Authors: Singh Anuwedita , Mishra P. K. , Das S. 
Published: October 2018

AbstractThe present article deals with the investigation of elasto‐dynamic response of a finite crack under normal and shear impact loading situated at the interface of two semi‐infinite orthotropic strips. Laplace and Fourier Integral transforms are employed to reduce the transient problem to the solution of a pair of dual integral equations in the Laplace transform plane which are solved using iterations in the low frequency domain. The analytical expressions of stress intensity factors of the crack at the interface problem are found. To determine time dependence of the parameters, these equations are inverted to yield the dynamic stress intensity factors for some fiber‐reinforced orthotropic composite materials using Bellman method and the method given by H. Dubner and J. Abate. The results are depicted through graphs for different particular cases.
The Power of Microdata: An Introduction
Authors: Crato Nuno , Paruolo Paolo 
Published: October 2018

AbstractPublic organisations collect, supervise and keep track of extremely varied and extensive types of data. Modern technologies and better-organised civil lives have greatly facilitated the collection and custody of these data with a minute granularity and a scale previously unknown. This allows for a much more detailed and sound knowledge of economies and societies. Action should be taken to use these data for a better, easier and more cost-effective evaluation of policies while safeguarding confidentiality of data. At a moment of increasing attention to the efficacy of public spending, it is more important than ever to be able to learn what effects policy measures have on citizens’ lives and societies.
The Use of Administrative Data to Evaluate the Impact of Active Labor Market Policies: The Case of the Italian Liste di Mobilità
Authors: Rettore Enrico , Trivellato Ugo 
Published: October 2018

AbstractAdministrative data are a valuable source of information in several ways for the design of an impact evaluation. Conditional on providing the information required for the evaluation, they feature major advantages: they cover the whole (sub)population of reference for their administrative purposes, and not just a sample of individuals; very often they extend over long time periods; they are not susceptible to the typical measurement errors of survey data; and, finally, they are free of charge. The case of the Italian Liste di Mobilità, an Active Labor Market Policy (ALPM) to handle collective redundancies, illustrates how much empirical labor economics can benefit from having access to this kind of data. The accessibility of administrative archives for scientific purposes is a critical issue, as the history of this scheme demonstrates.
Negative Home Equity and Job Mobility
Authors: Morescalchi Andrea , van Veldhuizen Sander , Voogt Bart , Vogt Benedikt 
Published: October 2018

AbstractThis chapter investigates the impact of negative home equity on job mobility. Panel fixed-effects estimation is carried out by making use of a Dutch administrative data set for the period 2006–2011. Endogeneity of home equity is taken into account by considering homeowners who fall underwater because of an exogenous price decline. They are compared with homeowners with positive home equity. Negative home equity has a moderate negative effect on the probability of changing jobs. If a household plunges into negative home equity, the head of the household is about 5.2% less likely to change jobs.
Long-Term Effects of a Social Intervention for Vulnerable Youth: A Register-Based Study
Authors: Arendt Jacob Nielsen , Verner Mette 
Published: October 2018

AbstractThis chapter provides new evidence on the effects of multisystemic therapy (MST), which is a social intervention for youth with conduct disorder problems. New data are provided on young people receiving MST in the years 2007–2011. Register data enable the construction of a comparison group of youth who are receiving alternative social treatments but who have similar parental characteristics and a similar life-cycle profile of previous social interventions and health-care use. It is found that MST participants are more likely than similar youth in alternative interventions to take primary school exams, and fewer MST participants with previous convictions are placed outside their homes. However, MST participants have lower upper secondary education completion rates and lower employment rates, are more dependent upon welfare income, and are more often convicted of crimes.
Designing Evaluation of Modern Apprenticeships in Scotland
Authors: Bajgar Matej , Criscuolo Chiara 
Published: October 2018

AbstractThis chapter outlines how the impacts of a major vocational training programme can be evaluated with the use of linked administrative and survey data. To do so, it presents a strategy for future evaluations of Modern Apprenticeships in Scotland. Drawing on lessons from the existing literature, it describes the options and preferred choices for examined outcomes, data sources and evaluation approaches. It argues that future evaluations should focus mainly on individual employment and wages, and on firm productivity outcomes; they should rely mainly on existing administrative data and use two distinct control groups, consisting of non-participants and non-completers. The chapter also illustrates how the evaluator can use narrower control groups, matching techniques, regression analysis and changes over time to better identify causal effects.
Pay for Performance in Primary Care: The Use of Administrative Data by Health Economists
Authors: Santos Rita , Barsanti Sara , Seghieri Chiara 
Published: October 2018

AbstractThe purpose of this chapter is to report how researchers in health economics and management have benefited from the linkage of several administrative datasets to measure the performance and analyse pay for performance schemes in primary care (PC) in England and in Italy (Tuscany Region). The chapter firstly addresses pay for performance schemes at international level, focusing on performance indicators, incentive schemes and data sources. Secondly, it focuses on the English Quality and Outcomes Framework (QOF) and the Tuscany Region performance evaluation system (PES). In particular, it describes the impact of the QOF incentives to general practices (family medical surgeries) in improving chronic care conditions, measured through indicators of preventable emergency admissions. The chapter also describes how the PES for health care in Tuscany Region has been extended to the evaluation of primary care and discusses preliminary results in terms of improvements.
Access to European Statistical System Microdata
Authors: Bujnowska Aleksandra 
Published: October 2018

AbstractThe chapter presents the European microdata access system. This system allows eligible researchers to analyse detailed data transmitted to Eurostat by national statistical offices in the European Union. Eurostat is a single entry point of access to such data. Individual data collected by national statistical offices to produce official statistics are strictly confidential. The data are anonymised and further processed before they can be made available for scientific purposes. Statistical offices are legally obliged to protect information received from individual respondents. They use this information solely to produce official statistics. The entities collecting data for other purposes (e.g. administrative, commercial or health) fall into the scope of personal data protection legislation. Statistical confidentiality measures are stricter than those resulting from personal data protection measures.
Giving the International Scientific Community Access to German Labor Market Data: A Success Story
Authors: Müller Dana , Möller Joachim 
Published: October 2018

AbstractSocial security data are an important resource for labor market research. In Germany, the Institute for Employment Research (IAB) of the Federal Employment Agency is responsible for processing these data resources into microdata products and linking them to surveys on individuals and establishments. Since 2004, IAB’s standardized data products have been offered to external scholars by the Institute’s Research Data Center. The provision of data resources to the international scientific community is a great success story. The number of worldwide users is growing steadily. Furthermore, cooperation projects have significantly increased knowledge on the structures and processes of the German labor market. Today, the IAB is part of a worldwide network of top-tier labor market researchers and has substantially improved its evidence-based policy advice.
Hungary: A Case Study on Improving Access to Administrative Data in a Low-Trust Environment
Authors: Scharle Ágota 
Published: October 2018

AbstractHungary introduced a law ensuring access to anonymised personal data for research and policymaking in 2007. The law has forged a compromise between strict provisions on personal data protection and researchers’ needs for microdata that has passed the test of practical application. The Hungarian case may be a model for improving access to administrative data for research and policy analysis in a low-trust environment. The chapter explores stakeholder interests and the negotiation process leading to the new law and also highlights how particular features of the new law satisfied opponents while meeting the demands of data users.
In the Spirit of Oil: Unintended Flows and Leaky Lives in Northeastern Ecuador
Authors: Krøijer Stine 
Published: October 2018

AbstractThe chapter by Krøijer considers the devastating consequences of the penetration of the extractive frontier into indigenous territories in Ecuador. She examines the strategies followed by the Sieko-pai for dealing with the transformations to their world caused by decades of oil exploitation. Instead of assuming essences, Krøijer pursues the analytical implications of specific ontological enquiries about oil flows, and how indigenous communities make their lives in a world saturated by extractivism. Documenting the Sieko-pai’s similar considerations about the incorrect treatment of both oil and blood as potential disruptions of positive ‘flows’ between their territory‚ body‚ and powerful ‘others,’ she contributes to current debates around the ontological analogy between oil and the so-called blood of subterranean spirits. Krøijer describes how living with oil extraction hinges on and expresses the Sieko-pai’s flexible ability to deal with transformations and the leaky reality of resource enclaves.
Water as Resource and Being: Water Extractivism and Life Projects in Peru
Authors: Stensrud Astrid B. 
Published: October 2018

AbstractWhile most studies focus on the boom in oil, minerals, and logging, Stensrud’s chapter explores another form of extractivism, which is growing in importance: the extraction of economic value from the water that flows to infrastructural megaprojects, which are damming the water for agribusiness. Focusing on the implications of the Majes Irrigation Project (MIP) for Quechua-speaking farmers in Peru, and how they make claims to the water springing from the mountains, Stensrud analyses the conditions that make land claims in Majes possible. Their claims are connected to notions of belonging and ownership that emerge from particular ontological compositions of water, mountains, personhood, and earth-beings that are not deliberately invented as part of an indigenous strategy to stop extractivism. Rather, these compositions form part of relationships that are continuously nurtured as part of ongoing life projects that conflict with the extractivist and modernising project of colonising water by turning it into an economic resource.
The Silent ‘Cosmopolitics’ of Artefacts: Spectral Extractivism, Ownership and ‘Obedient’ Things in Cañaris (Peru)
Authors: Rivera Andía Juan Javier 
Published: October 2018

AbstractThe chapter by Rivera Andía examines the terms by which the Cañaris Quechua-speaking people of the Northern Peruvian highlands establish their relationship with the land in a context marked by a ghostly extractivism. Leaving open the possibility of a radically distinct multiplicity of an environment with whom humans relate in social terms that exceed modern conceptions of private property, he describes local practices and conceptions relating to the production, access, and administration of land. What emerges is an entity that is less ‘natural’ and ‘indigenous’ than what is usually the focus of Andean ethnographies: the Iglisya (Quechua term for Spanish iglesia, church). Clandestinely built of earth and plants by eighteenth-century Indians, this land- and child-temple does not only represent the land but constitutes it. Rivera Andía considers the material and ritual aspects of the human-land relationship that produces the Iglisya as a truly cosmopolitical device with which Cañarenses are able to contend on their own terms with the threat of extractivism.
Stories of Resistance: Translating Nature, Indigeneity, and Place in Mining Activism
Authors: Li Fabiana , Paredes Peñafiel Adriana Paola 
Published: October 2018

AbstractThe chapter by Li and Paredes Peñafiel explores the manifold interconnections between community-based resistance and national as well as international activist networks. They trace the organised opposition to a proposed mining project in Peru’s Northern Highlands (the Conga mine) and how local activism travels through documentaries, news media, lawsuits, and networks. Analysing the international reverberations of the conflict and activist efforts, they interrogate the emergence of key leaders—particularly women—and how they and media actors represent the conflict. These representations of environmental conflict in Peru also gain importance elsewhere, and the authors explore how they both travel and translate into a situation of increasing resistance to extraction in Rio Grande do Sul, Brazil. Local resistance thus reverberates and spreads and may challenge the logic of extractivism by opening up a space for alternative life-making projects that both transcend and communicate between connections to a local landscape.
Brief report: A qualitative evidence synthesis of the psychological processes of school‐based expressive writing interventions with adolescents
Authors: Doucet Marie‐Hélène , Farella Guzzo Maria , Groleau Danielle 
Published: October 2018

ABSTRACTIntroductionExpressive writing interventions consist of brief writing sessions on thoughts and emotions and are known to yield positive benefits on adolescents' mental health. However, the psychological mechanisms explaining these effects are not clear.MethodThis review explored the psychological processes underlying school‐based expressive writing interventions with adolescents. A thematic synthesis of qualitative research consisted of identifying, appraising and summarizing the qualitative evidence of eligible studies.ResultsOnly six of the 510 identified studies met the inclusion criteria of this review. Results provide some validation for cognitive‐processing, emotion‐regulation, and disinhibition as psychological mechanisms underlying school‐based expressive writing with adolescents.ConclusionsHowever, these conclusions are still preliminary because of the paucity of the qualitative evidence found, both in quantity and quality. We recommend that more rigorous and in‐depth qualitative research be undertaken to: 1) explore adolescents' subjective experience about the expressive writing intervention, using in‐depth individual interviews; 2) thoroughly assess the content of students' texts written during the intervention; and 3) document the process of expressive writing interventions through observational methods. The results of such investigations would support the development and implementation of school‐based expressive writing‐type of interventions adapted to adolescents.