bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analisis Pengelolaan Kas pada UMKM
Authors: Amaliyah Fitri , Yasmin Arifia , Hetika Hetika 
Published: November 2024

Effective cashflow management is very important for the continuity and growth of Micro, Small, and Medium Enterprises (MSMEs). With good cash management, it will be able to avoid liquidity problems, be able to make the right strategic decisions and ensure business continuity in the long term. The purpose of this study is to find out the cash management of Convection MSMEs in Tegal Regency. The data collection method in this study is using observation and interviews. Meanwhile, the sampling technique uses random sampling of 9 MSMEs in the Adiwerna District area. The results of the study found that the cash management carried out by Convection MSME owners in the Tegal Regency area is still very minimal. This can be seen from the fact that most MSME owners have not planned, monitored or controlled cash. Of the MSMEs that manage cash, most have not done cash planning. In addition, the monitoring carried out on cash by most MSME owners is only limited to recording cash receipts and cash expenditures in a simple way, namely recording in books alone is not in accordance with applicable accounting standards. Furthermore, the control carried out by MSMEs is also only limited to not giving too much receivables to customers and carrying out a strategy of providing discounts when their business experiences a decline in sales. This is due to the lack of financial literacy knowledge in managing their finances, especially in compiling financial reports
Mediasi Determinan Keberlanjutan Usaha Dengan Kinerja Pada Pelaku UMKM di Kota Bima
Authors: Pratiwi Aliah , Nurulrahmatiah Nafisah 
Published: November 2024

The purpose of this study is to determine the direct relationship between financial literacy, digital literacy and financial inclusion on the performance of MSMEs. As well as the indirect relationship between financial literacy, digital literacy and financial inclusion on the sustainability of MSMEs through performance. This research uses a quantitative approach method by distributing questionnaires. The population in this research is all MSMEs in Bima City. The sampling technique used is random sampling, namely random sampling based on a predetermined sample. The total sample was 100 respondents with a distribution of 20 respondents each in 5 sub-districts. The data analysis tool uses Smart PLS. The results of this research provide information that financial literacy, digital literacy and financial inclusion have an influence on the performance of MSMEs. Likewise, with indirect effects, the results show that financial literacy, digital literacy and financial inclusion influence the sustainability of MSMEs through performance.
Early mNGS testing for diagnose and prognostic prediction of early onset pneumonia among in-hospital cardiac arrest patients undergoing extracorporeal cardiopulmonary resuscitation
Authors: Guo Rui-ming , Li Xing-xing , Zhou Yi-heng , Liu Yi-juan , Li Jun , Fu Guo-wei , Zhao Hui , Zhang Xin , Zhao Yang-chao 
Published: November 2024

ObjectivesMetagenomic next-generation sequencing (mNGS) is emerging as a novel diagnostic technology for various infectious diseases; however, limited studies have investigated its application in etiological diagnosis of early onset pneumonia (EOP) among patients undergoing extracorporeal cardiopulmonary resuscitation (ECPR) following in-hospital cardiac arrest (IHCA), The clinical significance of early mNGS in predicting short-term prognosis of IHCA patients after ECPR remains unclear.MethodsThis retrospective study included 76 patients with IHCA who underwent ECPR at the First Affiliated Hospital of Zhengzhou University from January 2018 to December 2022. Baseline characteristics and etiological data of all patients during their hospitalization were collected and statistically analyzed. The primary outcome of this study was the diagnosis of EOP, while the secondary outcomes included successful extracorporeal membrane oxygenation (ECMO) weaning and survival at discharge. Additionally, the characteristics of bronchoalveolar lavage fluid (BALF) flora in these patients were compared by analyzing both mNGS results and culture results.ResultsMultivariate logistic regression were employed to analyze the predictors of ECMO weaning failure, mortality at discharge, and the incidence of EOP. Ultimately, patients with lower SOFA scores on admission [OR (95%CI): 1.447 (1.107-1.890), p=0.007] and those who underwent early mNGS testing within 48 hours after ECPR [OR (95%CI): 0.273 (0.086-0.865), p=0.027] demonstrated a higher probability of successful weaning from ECMO. Patients with higher SOFA scores on admission [OR (95%CI): 2.404 (1.422-4.064), p=0.001], and elevated lactate levels [OR (95%CI): 1.176 (1.017-1.361), p=0.029] exhibited an increased likelihood of mortality at discharge. Furthermore, early mNGS detection [OR (95%CI): 0.186 (0.035-0.979), p=0.047], and lower CRP levels (48h-7d after ECMO) [OR (95%CI):1.011 (1.003-1.019), p=0.006] were associated with a reduced incidence of EOP. In addition, the pathogens detected by mNGS within 48 hours after ECPR were mainly oral colonizing bacteria and viruses, and viruses were in the majority, while all BALF cultures were negative. In contrast, between 48 hours and 7 days after ECPR, BALF cultures were positive in all EOP patients.ConclusionsEarly mNGS testing to identify microbial flora facilitates timely adjustment of antibiotic regimens, thereby reducing the incidence of EOP and improving short-term prognosis in patients undergoing ECPR following IHCA.
Activation of MEK‐ERK‐c‐MYC signaling pathway promotes splenic M2-like macrophage polarization to inhibit PHcH-liver cirrhosis
Authors: Guihu Wang , Wei Dong , Hailong Zhang , Chongyu Zhang , Jin Sun , Mengchen Zhu , Jian Zhang , Rui Zhou , Song Ren , Chen Zhang , Xi Liu , Zongfang Li , An Jiang 
Published: November 2024

IntroductionPortal hypertension combined with hypersplenism (PHcH) is the main cause of hypocytosis and esophagogastric variceal hemorrhage in patients with liver cirrhosis. Activated macrophages that destroy excess blood cells are the main cause of hypersplenism, but the activating pathway is not very clear. This study aims to investigate the activation types of splenic macrophages and their activation mechanisms, to provide experimental evidence for the biological treatment of splenomegaly, and to find a strategy to improve liver fibrosis and inflammation by intervening in splenic immune cells. This study revealed the occurrence of M2-like polarization of macrophages and upregulation of c-Myc gene expression in the PH spleen.MethodsRNAseq, protein chip, western blot, and chip-seq were performed on macrophages and the in vitro MEK inhibitor rafametinib was used. Carbon tetrachloride and thioacetamide induced mouse cirrhosis models were separately constructed.Resultsc-Myc gene knockout in splenic macrophages reduced M2-like polarization and exacerbated liver fibrosis inflammation. c-Myc activated the MAPK signaling pathway and upregulated the expression of IL-4 and M2-like related genes in PH hypersplenism through the MEK-ERK-c-Myc axis. In addition, the c-Myc gene exerted anti-inflammatory effects by upregulating IL-4-mediated signal transduction to promote M2-like differentiation and anti-inflammatory cytokine secretion.ConclusionsActivation of MEK‐ERK‐c‐MYC signaling pathway promotes splenic M2-like macrophage polarization to inhibit PHcH-liver cirrhosis. Therefore, the induction of macrophage depolarization might represent a new therapeutic approach in the cure of PH hypersplenism, making c-Myc a potential candidate for macrophage polarization therapy.
GPER1 signaling restricts macrophage proliferation and accumulation in human hepatocellular carcinoma
Authors: Yang Yanyan , Wang Yongchun , Zou Hao , Li Zhixiong , Chen Weibai , Huang Zhijie , Weng Yulan , Yu Xingjuan , Xu Jing , Zheng Limin 
Published: November 2024

BackgroundSex hormones and their related receptors have been reported to impact the development and progression of tumors. However, their influence on the composition and function of the tumor microenvironment is not well understood. We aimed to investigate the influence of sex disparities on the proliferation and accumulation of macrophages, one of the major components of the tumor microenvironment, in hepatocellular carcinoma (HCC).MethodsImmunohistochemistry was applied to assess the density of immune cells in HCC tissues. The role of sex hormone related signaling in macrophage proliferation was determined by immunofluorescence and flow cytometry. The underlying regulatory mechanisms were examined with both in vitro experiments and murine HCC models.ResultsWe found higher levels of macrophage proliferation and density in tumor tissues from male patients compared to females. The expression of G protein–coupled estrogen receptor 1 (GPER1), a non-classical estrogen receptor, was significantly decreased in proliferating macrophages, and was inversely correlated with macrophage proliferation in HCC tumors. Activation of GPER1 signaling with a selective agonist G-1 suppressed macrophage proliferation by downregulating the MEK/ERK pathway. Additionally, G-1 treatment reduced PD-L1 expression on macrophages and delayed tumor growth in mice. Moreover, patients with a higher percentage of GPER1+ macrophages exhibited longer overall survival and recurrence-free survival compared to those with a lower level.ConclusionsThese findings reveal a novel role of GPER1 signaling in regulating macrophage proliferation and function in HCC tumors and may offer a potential strategy for designing therapies based on understanding sex-related disparities of patients.
FLAIR vascular hyperintensity is associated with functional outcome in patients with ischemic stroke receiving endovascular treatment: a meta-analysis
Authors: Wang Chunyan , Wang Chuanliu , Ni Yongjun 
Published: November 2024

BackgroundFluid-attenuated inversion recovery (FLAIR) vascular hyperintensity (FVH) might be useful for predicting and functional outcome in ischemic stroke patients after endovascular thrombectomy (EVT), but its clinical benefit remains controversial. Thus, this study aimed to evaluate the association of FVH on prognosis in ischemic stroke patients who received EVT.MethodsPubMed, Embase, Cochrane Library, Web of Science, and Wanfang databases were searched for potentially eligible studies published up to March 2024. Pooled standard mean difference (SMD), risk ratios (RR) with 95% confidence intervals (CI) were employed to assess the association of FVH on prognosis in ischemic stroke patients who received EVT. All statistical analyses were conducted using STATA 12.0 software.ResultsA total of 10 studies were included in our study. The results indicated that higher FVH score were associated with better prognosis (SMD: 0.80, 95% CI 0.63–0.97). Moreover, the presence of FVH was significant associated with better functional outcome in ischemic stroke patients who received EVT (RR: 0.68, 95% CI, 0.58–0.79).ConclusionThe current meta-analysis suggests that FVH is related the prognosis of ischemic stroke patients after EVT.
Development and validation of a nomogram to predict the survival and estimate surgical benefits for gastric cancer with liver metastasis receiving primary tumor resection
Authors: Su Rishun , Sun Xuezeng , Chen Songyao , Deng Guofei , Yin Songcheng , He Yulong , Hao Tengfei , Gu Liang , Zhang Changhua 
Published: November 2024

BackgroundSurgical treatment has been widely controversial for gastric cancer accompanied by liver metastasis (GCLM). This paper aims to develop and validate a nomogram to predict the survival and estimate surgical benefits for GCLM patients.MethodsA total of 616 GCLM patients from the Surveillance, Epidemiology, and End Results Program (SEER) database and 74 GCLM patients receiving primary tumor resection (PTR) from the Chinese center were included in this study. Patients from the SEER database were divided into training set (with PTR) (n=493) and non-operative set (without PTR) (n=123). Patients undergoing PTR from China were included as external validation set. Independent risk factors associated with the overall survival of GCLM patients undergoing PTR were identified in the training set via log-rank test and Cox regression analysis. Afterwards, a comprehensive model and corresponding nomogram were constructed and validated by validation set.ResultsThe survival of patients undergoing PTR (n=493) was longer than that without PTR (n=123) (log-rank test, p&lt;0.0001) in SEER cohort. T stage (HR=1.40, 95% CI=1.14, 1.73), differentiation grade (HR=1.47, 95% CI=1.17, 1.85), non-hepatic metastases (HR=1.69, 95% CI=1.29, 2.21), and adjuvant therapy (HR=0.34, 95% CI= 0.28, 0.42) were closely related with the survival of GCLM with PTR, and thus, a four-factor nomogram was established. However, GCLM patients receiving PTR in the high-risk subgroup (n=255) screened out by the nomogram did not have better survival outcomes compared with patients without PTR (n=123) (log-rank test, p=0.25).ConclusionsThe nomogram could predict survival of GCLM patients receiving PTR with acceptable accuracy. In addition, although PTR did improve the survival of whole GCLM patients, patients in the high-risk subgroup were unable to benefit from PTR, which could assist clinicians to make decisions for the treatment of GCLM.
Development and validation of a nomogram for predicting histologic subtypes of subpleural non-small cell lung cancer using ultrasound parameters and clinical data
Authors: Mao Feng , Shen Mengjun , Zhang Yi , Chen Hongwei , Cong Yang , Zhu Huiming , Tang Chunhong , Zhang Shengmin , Wang Yin 
Published: November 2024

AimsTo develop and validate an individualized nomogram for differentiating the histologic subtypes (adenocarcinoma and squamous cell carcinoma) of subpleural non-small cell lung cancer (NSCLC) based on ultrasound parameters and clinical data.MethodsThis study was conducted retrospectively between March 2018 and December 2019. Patients were randomly assigned to a development cohort (DC, n=179) and a validation cohort (VC, n=77). A total of 7 clinical parameters and 16 ultrasound parameters were collected. Least absolute shrinkage and selection operator regression analysis was employed to identify the most significant predictors utilizing a 10-fold cross-validation. The multivariate logistic regression model was applied to investigate the relevant factors. An individualized nomogram was then developed. Receiver operating characteristic (ROC) curve, calibration plot and decision curve analysis (DCA) were applied for model validation in both DC and VC.ResultsFollowing the final regression analysis, gender, serum carcinoembryonic antigen, lesion size and perfusion defect in contrast-enhanced ultrasound were entered into the nomogram. The model showed moderate predictive ability, with an area under the ROC curve of 0.867 for DC and 0.838 for VC. The calibration curves of the model showed good agreement between actual and predicted probabilities. The ROC and DCA curves demonstrated that the nomogram exhibited a good predictive performance.ConclusionWe developed a nomogram that can predict the histologic subtypes of subpleural NSCLC. Both internal and external validation revealed optimal discrimination and calibration, indicating that the nomogram may have clinical utility. This model has the potential to assist clinicians in making treatment recommendations.
Huyang Yangkun formula regulates the mitochondria pathway of ovarian granulosa cell apoptosis through FTO/m6A-P53 pathway
Authors: Li Yang , Wang Lingdi , Liu Jian , Nie Guangning , Yang Hongyan 
Published: November 2024

BackgroundPremature ovarian insufficiency (POI) presents a significant challenge to female reproductive health. The Huyang Yangkun Formula (HYF), a traditional Chinese medicinal formulation, has been utilized in clinical settings for the treatment of POI for over a decade. Nevertheless, the therapeutic application of HYF is considerably constrained by the lack of clarity regarding its underlying mechanism of action.MethodsThe experimental procedures entailed administering VCD to female Sprague-Dawley rats at a dosage of 160 mg/kg/day over a period of 15 days, succeeded by a 100-day treatment with HYF. Blood serum samples were collected and analyzed using ELISA to quantify the concentrations of Anti-Müllerian Hormone (AMH), Follicle-Stimulating Hormone (FSH), and Estradiol (E2). The levels of N6-methyladenosine (m6A) were assessed through Dot blot analysis and liquid chromatography-tandem mass spectrometry (LC-MS/MS). Western blotting was employed to validate the differential expression of m6A-related catalytic enzymes and apoptosis-related regulators, including BCL-2, BCL-XL, and MCL-1, which may be implicated in the effects of HYF. Certain shRNA-COV434 cell line was constructed for the exploration of molecular mechanism, and then the potential targets were finally verified by MeRIP-qPCR.ResultsHYF has been identified as having a significant influence on the development of residual ovarian follicles in rats with POI, especially during the initial stages. It was observed that HYF facilitates the progression of escaping antral follicles to full maturation. Additionally, HYF exhibited the capacity to enhance the proliferation of COV434, a human ovarian granulosa cell line, while concurrently inhibiting apoptosis within these cells. Notably, HYF treatment resulted in the downregulation of apoptotic proteins, including BCL-XL, cleaved-caspase 9, cleaved-caspase 3, and Bcl-2. Concurrently, m6A modification is implicated in the regulation of HYF. Both in vitro and in vivo studies indicate that FTO may play a role in the anti-apoptotic mechanisms mediated by m6A in ovarian granulosa cells influenced by HYF. Moreover, employing qPCR and MeRIP-qPCR techniques, P53 has been identified as the target gene for m6A modification mediated by FTO.ConclusionThese findings suggest that HYF holds promise as a potential treatment for POI and provide a more comprehensive understanding of the mechanism by which HYF operates, specifically its ability to prevent the BCL-2 mitochondrial apoptosis pathway mediated by P53 in ovarian granulosa cells of POI rats by regulating FTO/m6A-Tp53.
Exploring the role of TikTok for intersectionality marginalized groups: the case of Muslim female content creators in Germany
Authors: El Sayed Fatima , Hotait Nader 
Published: November 2024

IntroductionSocial media has become a central part of everyday life, providing spaces for communication, self-expression, and social mobilization. TikTok, specifically, has emerged as a prominent platform for marginalized groups, providing opportunities for activism and representation. However, research falls short in examining the specific role of TikTok for Muslim women in Germany who face intersecting forms of marginalization. This shortcoming reflects a broader lack of research on the experiences of marginalized groups within TikTok’s logics and affordances, and what functions the platform fulfills for these communities. Against this backdrop, this study examines TikTok’s role as a platform for Muslim female content creators in Germany and its broader implications for marginalized communities. Our research is guided by the following questions: (a) What are the main themes and topics that are being brought forward by Muslim women content creators on TikTok? (b) What technical affordances do they use to communicate their content? (c) What functions does TikTok fulfill for Muslim women as an intersectionally marginalized group?.MethodsWe analyze 320 videos from 32 public TikTok accounts identified through snowball sampling. Data collection includes automated web scraping, manual transcription, and qualitative coding. This allows us to identify main topics, video formats, and content types to answer our research questions.ResultsOur findings show that Muslim women produce diverse content on TikTok, ranging from beauty and lifestyle to religious education and social justice. They shape the platform’s functionalities through creative use, while TikTok’s algorithm and virality logic drive creators to blend entertainment with personal content. The hijab emerges as a unique issue, framed within both political and fashion discourses. Overall, TikTok functions as a “third space” where Muslim women challenge mainstream stereotypes and offer alternative interpretations of their identity. While TikTok provides empowerment and visibility, it also exposes Muslim women to hate speech and harassment. The platform provides tools to counter these issues, but the underlying social hierarchies often limit their visibility, making TikTok both a site of empowerment and vulnerability.DiscussionThis study highlights the need for further research into the role of social media for marginalized groups, particularly across platforms, gender, and religion.
How stress influences short video addiction in China: an extended compensatory internet use model
Authors: Hu Huiyuan , Huang Meilin 
Published: November 2024

IntroductionThe rise of short video applications has become a defining feature of modern digital media consumption, drawing increasing attention from researchers due to issues related to short video addiction. While earlier studies have examined the perceived stress as a cause of short video addiction, there is limited understanding of the potential mechanisms underlying the relationship between these two variables. Building on compensatory Internet use (CIU) theory, this study introduces an extended model (E-CIU) to explore how stress, compensatory motivations (i.e., social interaction and relaxing entertainment), and affective responses (i.e., immersion and attitude) relate to short video addiction. This study also examines differences between the age groups.MethodsData from 319 Chinese short video users were tested applying partial least squares structural equation modeling (PLS-SEM) and PLS-SEM multigroup analysis.ResultsFindings indicate that stress, immersion, and attitude each contribute positively to short video addiction. Stress is linked to both social interaction and relaxing entertainment. While both factors positively affect attitude toward short videos, only relaxing entertainment enhances immersion. Results confirmed the perceived stress indirectly influences short video addiction through a serial mediating pathway comprising motivations and affective responses. Moreover, the study shows that perceived stress influences social interaction, relaxing entertainment influences attitude and immersion, and social interaction influences immersion across all age groups. The study further identified variations in how different groups experience the relationship between stress and addiction, stress and relaxation, attitude and addiction, and immersion and addiction.DiscussionConsequently, this study enriches the understanding of the E-CIU as a new theoretical model of short video addiction. These insights offer practical recommendations for short video applications to address user engagement and addiction more effectively.