bluuebunny/crossref_metadata_2025_split huggingface dataset:
Activating Mutations in Pik3ca Contribute to Anal Carcinogenesis in the Presence or Absence of HPV-16 Oncogenes
Authors: Shin Myeong-Kyun , Payne Susan , Bilger Andrea , Matkowskyj Kristina A. , Carchman Evie , Meyer Dominique S. , Bentires-Alj Mohamed , Deming Dustin A. , Lambert Paul F. 
Published: December 2018

Abstract

Purpose:
Over 95% of human anal cancers are etiologically associated with high-risk HPVs, with HPV type 16 (HPV16) the genotype most commonly found. Activating mutations in the catalytic subunit of Phosphatidylinositol (3,4,5)-trisphosphate kinase (PI3K), encoded by the Pik3ca gene, are detected in approximately 20% of human anal cancers.
Experimental Design: We asked if common activating mutations in Pik3ca contribute to anal carcinogenesis using an established mouse model for anal carcinogenesis in which mice are topically treated with the chemical carcinogen 7,12-Dimethylbenz(a)anthracene (DMBA). Mice expressing in their anal epithelium one of two activating mutations in Pik3ca genes, Pik3caH1047R or Pik3caE545K, were monitored for anal carcinogenesis in the presence or absence of transgenes expressing the HPV16 E6 and E7 oncogenes.

Results:
Both mutant forms of Pik3ca increased susceptibility to anal carcinogenesis in the absence of HPV16 oncogenes, and cooperated with HPV16 oncogenes to induce the highest level and earliest onset of anal cancers. The combination of HPV16 oncogenes and Pik3ca mutations led to anal cancers even in the absence of treatment with DMBA. We further observed that the investigational mTOR1/2 dual inhibitor, TAK-228, significantly reduced the size of anal cancer-derived tumor spheroids in vitro and reduced the growth rates of anal cancer-derived tumor grafts in vivo.

Conclusions:
These data demonstrate that activating mutations in Pik3ca drive anal carcinogenesis together with HPV16 oncogenes, and that the PI3K/mTOR pathway is a relevant target for therapeutic intervention.
The Theodramatic Imagination: Spirit and Imagination in the Work of Kevin Vanhoozer
Authors: Bailey Justin Ariel 
Published: December 2018

Abstract
This article situates and evaluates the cultural hermeneutic method of theologian Kevin Vanhoozer. His “theodramatic imagination” sets forth a method for rightly interpreting both Scripture and culture. Fellow theologian William Dyrness criticizes Vanhoozer’s model as theoretical rather than theatrical, focused on extracted ideas instead of embedded imaginaries. The article argues that, although Dyrness’ critique misses its mark, the true disagreement is pneumatological in nature. In the view of the author, this is the real limitation for Vanhoozer’s method: he prepares us to recognize and respond to the Spirit at work in shaping the Church’s “theodramatic” imagination, but we are less equipped to recognize the same Spirit outside the walls of the church, where much of the drama of redemption is set. Constructively, this article develops Vanhoozer’s cultural hermeneutic with a stronger connection to the presence of the Holy Spirit in the wider world, employing an underdeveloped concept from Vanhoozer’s theology.
Street food in Maputo, Mozambique: Availability and nutritional value of homemade foods
Authors: Sousa Sofia , Gelormini Marcello , Damasceno Albertino , Lopes Simão A , Maló Sérgio , Chongole Célia , Muholove Paulino , Casal Susana , Pinho Olívia , Moreira Pedro , Lunet Nuno , Padrão Patrícia 
Published: December 2018

Background: A nutrition transition is occurring in the urban areas of developing countries, where street food makes an important contribution to daily food intake. Aim: We aimed to characterise street food offer in Maputo, Mozambique, and to evaluate the nutritional composition of the most common homemade foods. Methods: A cross-sectional study was conducted in 2014. Streets in the surroundings (500 m buffer) of randomly selected public transport stops in KaMpfumu district, Maputo, were canvassed to identify all street food vending sites ( n = 968). Information regarding vending site characteristics and the food offered was gathered through interview and observation. Samples ( n = 80) of the most common homemade foods were collected for laboratorial analysis. Results: Most street food vending sites identified were stationary (77.4%) and sold exclusively industrial food (51.9%). Frequency of fruit, beverages and food other than fruit was 24.5%, 32.5% and 73.9%, respectively. Fried cakes were the most energy-dense (430 kcal/100 g), and richest in fats (21.0g/100 g) and carbohydrates (53.4 g/100 g). The richest sources of protein were the stewed meat/fish/liver dishes (10.7–11.6 g/100 g). Fried cakes showed the lowest sodium and potassium content (90 mg/100 g and 81 mg/100 g, respectively) whereas hamburgers exhibited the highest content of those micronutrients (455 mg/100 g and 183 mg/100 g, respectively). Stewed liver dishes presented the highest sodium/potassium ratio (11.95). Fried snacks presented the highest trans-fatty acid content (0.20 g/100 g). Conclusions: Street food in Maputo is abundant and scattered throughout the urban district, exhibiting high variability in the nutritional composition of homemade foods. Public health policies should be targeted to improve the street food offer, promoting nutrient-dense foods and the reduction of added salt.
Clinical manifestations and causes of gelsemium poisoning in Hong Kong from 2005 to 2017: Review of 33 cases
Authors: Chow Tin Yat Anthony , Ng Chun Ho Vember , Tse Man Li 
Published: December 2018

Background: Gelsemium elegans is an extremely toxic plant, but gelsemium poisoning is seldom reported in the English literature. Objectives: To evaluate the clinical manifestations and causes of gelsemium poisoning in Hong Kong. Methods: A retrospective review of gelsemium poisoning recorded by the Hong Kong Poison Information Centre from 2005 to 2017. Results: In total, 33 cases (55% female, median age 44 (interquartile range: 30–56)) were identified in 14 incidences. Consumption of contaminated Ficus hirta (五指毛桃) soup is the commonest cause (52%). Other causes include misidentification of herbs (12%), consumption of parasitic plant Cassytha filiformis (無根藤) (15%) and suicidal ingestion of Gelsemium elegans (斷腸草) (3%). Most patients (94%) had mild to moderate toxicity, with one fatal case and one severe case presented with coma and respiratory depression. All patients complained of dizziness (100%), followed by visual blurring (34%) and nausea (28%). More than half (53%) had ocular manifestations (e.g. visual blurring, ptosis, nystagmus, diplopia) which are not commonly reported in other herbal poisoning. The time of symptom onset was early (median: 50 min (interquartile range: 30–60)) and all occurred within 2 h after oral intake. Most patients (94%) recovered uneventfully with conservative treatment. Conclusion: Most gelsemium poisoning in Hong Kong was due to contamination or misidentification. Early-onset dizziness (<2 h) with ocular symptoms after herbs consumption highly suggests Gelsemium poisoning. Good supportive care, particularly respiratory support, is the mainstay of management. Early recognition and the corresponding preventive measures would be useful.
Cardiovascular stress biomarker assessment of middle-aged non-athlete marathon runners
Authors: Kosowski Michał , Młynarska Katarzyna , Chmura Jan , Kustrzycka-Kratochwil Dorota , Sukiennik-Kujawa Malgorzata , Todd John A , Jankowska Ewa A , Banasiak Waldemar , Reczuch Krzysztof , Ponikowski Piotr 
Published: December 2018

Background Cardiovascular safety of marathon running in recreational runners remains unclear. We set up this study to comprehensively evaluate the effects of a marathon run on the profile of cardiovascular stress biomarkers in connection with transthoracic echocardiography. Design and methods Thirty-three healthy male amateur runners, aged ≥50 years (mean age 57 ± 7) were enrolled. Venous blood samples were obtained before the marathon, just after the race, 2–4 and seven days after the marathon. Using novel single molecule counting technology we measured: plasma concentrations of high-sensitivity cardiac troponin I (hs-cTnI) and endothelin-1. N-terminal pro B-type natriuretic peptide was measured using electrochemiluminescence. Each participant had transthoracic echocardiography before and immediately after the race. Results We observed a sharp rise in the levels of all biomarkers after the race (all p < 0.01), which subsequently normalized after 2–4 days and stayed within normal range after seven days. Runners with intensive training programmes (>169 km/month, a median for the studied group) had lower hs-cTnI leak after the race (median 15.11 ng/ml and 31.2 ng/ml, respectively; p < 0.05). Neither transthoracic echocardiography measures of ventricles nor strain rates changed after the run. We observed a decrease in the left atrial volume index and increase in the maximal right atrial volumes (all p < 0.05). Changes in Doppler indices of diastolic function suggestive of alteration in left ventricular relaxation were observed. Conclusions Marathon run is associated with sharp and significant rises in the biomarkers of cardiovascular stress. The profile of these changes, however, along with echocardiographic parameters, does not suggest irreversible myocardial damage.
Do pathologists agree with each other on the histological assessment of pT1b oesophageal adenocarcinoma?
Authors: Gotink Annieke W , ten Kate Fiebo JC , Doukas Michael , Wijnhoven Bas PL , Bruno Marco J , Looijenga Leendert HJ , Koch Arjun D , Biermann Katharina 
Published: December 2018

BackgroundIn early (T1) oesophageal adenocarcinoma (OAC), the histological profile of an endoscopic resection specimen plays a pivotal role in the prediction of lymph node metastasis and the potential need for oesophagectomy with lymphadenectomy.ObjectiveTo evaluate the inter‐observer agreement of the histological assessment of submucosal (pT1b) OAC.MethodsSurgical and endoscopic resection specimens with pT1b OAC were independently reviewed by three gastrointestinal pathologists. Agreement was determined by intraclass correlation coefficient for continuous variables, and Fleiss' kappa (κ) for categorical variables. Bland–Altman plots of the submucosal invasion depth were made.ResultsEighty‐five resection specimens with pT1b OAC were evaluated. The agreement was good for differentiation grade (κ=0.77, 95% confidence interval (CI) 0.68–0.87), excellent for lymphovascular invasion (κ=0.88, 95% CI 0.76–1.00) and moderate for submucosal invasion depth using the Paris and Pragmatic classifications (κ=0.60, 95% CI 0.49–0.72 and κ=0.42, 95% CI 0.33–0.51, respectively). Systematic mean differences between pathologists were detected for the measurement of submucosal invasion depth, ranging from 297 µm to 602 µm.ConclusionsA substantial discordance was found between pathologists for the measurement of submucosal invasion depth in pT1b OAC. Differences may lead to an over‐ or underestimation of the lymph node metastasis risk, with grave implications for the treatment strategy. Review by a second gastrointestinal pathologist is recommended to improve differentiating between a favourable and an unfavourable histological profile.
Transient loss of detectable HIV-1 RNA following brentuximab vedotin anti-CD30 therapy for Hodgkin lymphoma
Authors: Wang Chia-Ching , Thanh Cassandra , Gibson Erica A. , Ball-Burack Maya , Hogan Louise E. , Descours Benjamin , Jones Norman , Carvidi Alexander B. , Munter Sadie , Bakkour Sonia , Busch Michael P. , Milush Jeffrey M. , Deeks Steven G. , Henrich Timothy J. 
Published: December 2018

Key Points
Anti-CD30 therapy for Hodgkin lymphoma led to transient loss of detectable CD4+ T-cell HIV RNA and a decrease in residual plasma viremia. Targeting nonviral markers expressed on HIV-1 transcriptionally active cells may lead to reduced measures of HIV-1 persistence.
Lag Time Between Evidence and Guidelines: Can Clinical Pathways Bridge the Gap?
Authors: Rodríguez-Lopéz Joshua L. , Ling Diane C. , Heron Dwight E. , Beriwal Sushil 
Published: December 2018

PURPOSE: The 2018 American Society for Radiation Oncology guidelines state that hypofractionated whole-breast irradiation (HF-WBI) may be used for early-stage breast cancer regardless of age, although evidence to support this became available years ago. Before guideline publication, we sought to change the practice pattern within an integrated, comprehensive radiation oncology network using clinical pathways. METHODS: The breast clinical pathway was amended in January 2016 to allow HF-WBI as a pathway-concordant option for women younger than 50 years of age. In December 2016, the pathway was amended to mandate HF-WBI as the only pathway-concordant option. Women younger than 50 years of age treated for stage 0 to IIA breast cancer, without irradiation of regional nodes, were included. Potential predictors of hypofractionation use were analyzed using binary logistic regression. RESULTS: We identified 305 patients treated between 2013 and 2017. From 2013 to December 2015, HF-WBI use was 4.2%. After the first and second amendments, use increased to 53.1% ( P < .001) and 96.5% ( P < .001), respectively. Before amendment 1, there was no difference in use of hypofractionation at academic (2.6%) versus community (4.7%) sites ( P = .568). After amendment 1, academic practices were more likely to use hypofractionation (72.0% v 44.6%; P = .026). After amendment 2, there was, again, no difference between academic (100.0%) and community (95.3%) practices ( P = .999). CONCLUSION: With implementation of a clinical pathway that mandated use of HF-WBI regardless of age, HF-WBI use for women younger than 50 years of age rapidly increased from 4.2% to greater than 95%. Clinical pathways effectively standardize patterns of care to reflect the most up-to-date clinical evidence, independently of guideline publication.
Predicting lithium treatment response in bipolar patients using gender-specific gene expression biomarkers and machine learning
Authors: Eugene Andy R. , Masiak Jolanta , Eugene Beata 
Published: December 2018

Background: We sought to test the hypothesis that transcriptome-level gene signatures are differentially expressed between male and female bipolar patients, prior to lithium treatment, in a patient cohort who later were clinically classified as lithium treatment responders. Methods: Gene expression study data was obtained from the Lithium Treatment-Moderate dose Use Study data accessed from the National Center for Biotechnology Information’s Gene Expression Omnibus via accession number GSE4548. Differential gene expression analysis was conducted using the Linear Models for Microarray and RNA-Seq (limma) package and the Decision Tree and Random Forest machine learning algorithms in R. Results: Using quantitative gene expression values reported from patient blood samples, the RBPMS2 and LILRA5 genes classify male lithium responders with an area under the receiver operator characteristic curve (AUROC) of 0.92 and the ABRACL, FHL3, and NBPF14 genes classify female lithium responders AUROC of 1. A Decision Tree rule for establishing male versus female samples, using gene expression values were found to be: if RPS4Y1 ≥ 9.643, patient is a male and if RPS4Y1 < 9.643, patient is female with a probability=100%. Conclusions: We developed a pre-treatment gender- and gene-expression-based predictive model selective for classifying male lithium responders with a sensitivity of 96% using 2-genes and female lithium responders with sensitivity=92% using 3-genes.
Usual care for mental health problems in children with epilepsy: A cohort study
Authors: Welch Alice , Shafran Roz , Heyman Isobel , Coughtrey Anna , Bennett Sophie 
Published: December 2018

Background: Epilepsy is one of the most common chronic paediatric conditions. Children and young people with epilepsy are at a significantly higher risk of developing mental health problems relative to the general population, yet the majority of these problems are unrecognised and under-treated in clinical practice. Although there is little epilepsy-specific guidance as to what interventions to use, researchers suggest there is no reason why clinicians should not be using the evidence base. Given the poor prognosis of untreated mental health difficulties, this cohort study sought to identify what psychological treatment young people with epilepsy with mental health needs receive in routine practice. Methods: Participants were children and young people aged 3 to 18 attending paediatric neurology clinics. The parents of those children who met threshold for impairing symptoms on the Strengths and Difficulties questionnaire were asked to complete the Development and Well-being Assessment (DAWBA), an online clinical assessment designed to generate psychiatric diagnoses. Participants who met clinical threshold for a disorder according to the DAWBA were provided with a bespoke measure asking questions regarding their experience with treatment for mental health support. Results: 16 of the 46 parents who completed the DAWBA reported that they had experienced previous or current support for their child’s mental health difficulties. The mental health support offered to families was highly variable, inadequate and often not clearly compliant with existing UK National Institute for Health and Clinical Excellence (NICE) guidelines for mental health treatment in children and young people. Conclusions: The present study demonstrates the inconsistency and inadequacy of mental health provision for children and young people with epilepsy. Future work should explore reasons for the treatments offered failing to adhere to existing guidance for mental health difficulties in children, as well as possible solutions to this.
Translocating Metropolitan Display Strategies in Nineteenth-Century Europe: Frederick Stibbert, Henri Moser, and their Orientalist Style Rooms
Authors: Giese Francine , Varela Braga Ariane 
Published: December 2018

Abstract
In the nineteenth century, the display of Islamic art and furniture was not only integrated into ethnographic collections and international exhibitions, but also formed an essential part of the home of amateurs as well as of the political, social, and cultural elites. Private collections accounted for an important step towards the valorization and reception of Islamic art in the west. This article examines the display strategies of collections located at the crossroads between private and public space by closely examining two style rooms integrated in private museums – the Stibbert collection in Florence, Italy, and the Moser collection in Neuhausen, near Schaffhausen, Switzerland. Both collectors had first-hand experience of the Orient due to their travels, with Stibbert focusing on al-Andalus and Moser on Central Asia, which inspired them to build up extensive art collections. The examples illustrate the importance of transnational relations for the establishment and display of collections that re-contextualized objects by presenting them within seemingly authentic oriental atmospheres specifically created for this purpose.
Book Reviews
Authors: Kargon Jeremy , Kezer Zeynep , McClary Richard Piran , Türker Deniz , Wick Alexis 
Published: December 2018

Abstract
HOMELAND: ZIONISM AS HOUSING REGIME, 1860–2011, YAEL ALLWEIL (2017) New York, NY: Routledge, 304 pp., 192 b/w illus., ISBN 978-1-13877-605-0, $115 (hardback)
SEIZING JERUSALEM: THE ARCHITECTURES OF UNILATERAL UNIFICATION, ALONA NITZAN-SHIFTAN (2017) Minneapolis, MN: University of Minnesota Press, 376 pp., 129 b/w illus., 8 colour plates, ISBN 978-0-81669-428-0, $39.95 (paperback)
VIOLENCE AND THE CITY IN THE MODERN MIDDLE EAST, EDITED BY NELIDA FUCCARO (2016) Stanford, CA: Stanford University Press, 312 pp., 8 maps, 16 b&w illus., ISBN 978-0-80479-752-8, $27.95 (paperback); ISBN 978-0-80479-584-5, $90.00 (hardback)
IN THE SHADOW OF THE CHURCH: THE BUILDING OF MOSQUES IN EARLY MEDIEVAL SYRIA, MATTIA GIUDETTI (2017) Leiden and Boston: Brill, xi + 211 pp., 72 ills., ISBN 978-9-00432-570-8, $155.00 (hardback)
MEDITERRANEAN ENCOUNTERS: ARTISTS BETWEEN EUROPE AND THE OTTOMAN EMPIRE, 1774–1839, ELISABETH A. FRASER (2017) University Park, PA: The Pennsylvania State University Press, 299 pp., 43 colour/98 b&w illus., ISBN 978-0-27107-320-0, $ 89.95 (hardback)
DISLOCATING THE ORIENT: BRITISH MAPS AND THE MAKING OF THE MIDDLE EAST, 1854–1921, DANIEL FOLIARD (2017) Chicago, IL: University of Chicago Press, 336 pp., 47 b/w illus., ISBN 978-0-22645-133-6, $60 (hardback)
Mujeres en un MOOC. Brecha, Vulnerabilidad y Marcas de Género. Reflexiones desde un estudio de caso cualitativo
Authors: Montes-Rodríguez Ramón , Herrada-Valverde Rosario-Isabel , Martínez-Rodríguez Juan-Bautista 
Published: December 2018

La formación online,y en concreto los MOOC, parecen estar revolucionando las concepciones educativas más tradicionales, generando nuevos paradigmas. Sin embargo, parte de los supuestos en que se fundamentan estos paradigmas suelen ser ciegos a las diferencias de género en el acceso y uso de las tecnologías. En este texto se indaga en cómo estos nuevos diseños de formación en línea, tras una concepción horizontal del aprendizaje, pueden estar actuando de forma discriminatoria hacia las mujeres. Mediante un estudio de caso de corte cualitativo se aporta información sobre las siguientes cuestiones desde una perspectiva de género: (1) qué dificultades muestran los participantes y cómo las muestran, (2) cómo difieren sus formas de compartir, (3) cómo gestionan el tiempo y (4) de qué forma actúan frente a un contexto de masividad. Mediante entrevistas semiestructuradas y técnicas de etnografía virtual, los resultados nos informan sobre cómo este curso está entendiendo y compaginando los distintos niveles de acceso y dominio tecnológico; sobre la existencia de una clara asimetría en función de género a la hora de compartir conocimientos e información; y sobre cómo la deslocalización y la flexibilidad temporal para realizar este tipo de formación puede conllevar dificultades añadidas para ellas.
Kontaminasi Tembaga pada Mugil dussumieri (Actinopterygii: Mugilidae, Forsskål, 1775) yang Ditangkap di Perairan Semarang, Indonesia
Authors: Suryono Chrisna Adhi , Susilo Endang Sri , Arinianzah Aldo Rizqi , Setyati Wilis Ari , Irwani Irwani , Suryono Suryono 
Published: December 2018

Contamination of Copper in Mugil dussumeri (Actinopterygii: Mugilidae, Forsskål, 1775) which was caught in Semarang waters, Indonesia The marine environment in Semarang waters are highly polluted by heavy metals such as copper (Cu). On the other side, these areas have become producers of fishery commodities such as mullet fish Mugil dussumieri. The aims of this study was to determine the heavy metal content of Cu in mullet fish during wet monsoon (December 2017 and February 2018). Atomic Absorption Spectrophotometer were used to analysis of Cu concentration in marine water and fish meat. The results show that the Cu content in marine water was not detected while in the meat of mullet fish during December 2017 and February 2018 were 0.66 ± 0.07 mg/kg and 0,604 ± 0.217 mg/kg, respectively. The results were still within the quality standard for maximum limit of Cu content allowed in seafood by FAO/WHO. Lingkungan perairan laut di sekitar Semarang berpeluang sangat tinggi untuk terpolusi logam berat tembaga. Di lain sisi perairan ini menjadi daerah produksi perikanan seperti ikan belanak Mugil dussumieri. Tujuan dari penelitian ini adalah untuk mengetahui kandungan logam Cu dalam daging ikan belanak yang ditangkap selama musim penghujan (Desember 2017 dan Februari 2018). Untuk mengetahui konsentrasi Cu dalam air laut dan ikan belanak digunakan Atomic Absorption Spectrophotometer. Hasil penelitian menunjukkan bahwa konsentrasi logam Cu selama bulan Desember 2017 adalah 0.66 ± 0.07/kg dan selama bulan Februari 0,604 ± 0.217 mg/kg, sedangkan konsentrasi Cu dalam air laut tidak terdeteksi. Hasil penelitian dapat disimpulkan bahwa kandungan Cu dalam ikan belanak masih berada pada konsentrasi yang diperbolehkan oleh FAO/WHO.