bluuebunny/crossref_metadata_2025_split huggingface dataset:
Associations between sexual satisfaction and function and the severity of lower urinary tract symptoms among men in a rural sub-Saharan African community
Authors: Macnab Andrew J. , Stothers Lynn , Berkowitz Jonathan , Elliott Stacy , Bajunirwe Francis 
Published: February 2019

Introduction: The recognized association between erectile dysfunction (ED) with lower urinary tract symptoms (LUTS) from high-income countries is unreported from Africa. Authentic figures on prevalence of ED and LUTS from Africa are scarce in the literature. This study was conducted to quantify sexual function and satisfaction among Ugandan men in relation to LUTS severity.
Methods: A convenience sample of men participating in a parallel, cross-sectional survey was used. The population, men >55 years living in Sheema district, Uganda, were recruited into two cohorts: those living in the community and those seeking clinic care due to bother from LUTS. This was to ensure inclusion of a full spectrum of LUTS. The instruments were the International Prostate Symptom Score (IPSS) to quantify LUTS and the Epstein Inventory (EI) to assess four measures of sexual functioning. Bivariate analysis compared community and clinic cohort participants, LUTS severity, and each sexual functioning item with two-sample t-tests for means and Chi-square tests of independence for categorical versions.
Results: Participants included 415 men (238 community and 177 clinic) at mean age of 67.5 years vs. 62.9 (p<0.001) with mean IPSS of 9.32 vs. 17.07 (p≤0.001). Lower mean satisfaction with sexual activity and frequency of erections occurred in the clinic cohort (p≤0.001). Overall, all four questions assessing dissatisfaction with sexual function were significantly correlated with worsening LUTS; sexual satisfaction and frequency of sexual drive were also influenced by age and low levels of education.
Conclusions: These are the first data describing the severity relationship between LUTS and ED in African men. Respondents reported dissatisfaction in the past year with the level of their sexual activity, frequency of sexual drive, ability to have erections, and sexual performance that related statistically to the severity of their LUTS.
The My-T study: Patient satisfaction and preference comparing topical and nasal testosterone therapies
Authors: Lee Jay , Brock Gerald , Barkin Jack , Bryson Nathan , Gronski Matthew A. , Ormsby Ross 
Published: February 2019

Introduction: Natesto®, testosterone nasal gel (TNG) is an intranasal testosterone therapy (TTh) used to restore testosterone levels and improve symptoms of hypogonadism. Treatment requires application two (bid) or three (tid) times daily. The Treatment Satisfaction Questionnaire for Medication (TSQM) and a Patient Preference and Use (PPU) Questionnaire were used to obtain patient feedback on the use of TNG and compare to experience with topical TTh.
Methods: The study enrolled 24 TTh-naive (TThN) and 93 TTh-experienced (TThE) hypogonadal men. Treatment lasted up to 120 days, with titration at day 90 to determine the most appropriate dose for restoration of testosterone levels (11 mg bid or tid). Patient satisfaction and symptom changes were measured at days 0, 30, 60, 90, and 120. The PPU Questionnaire was performed at study entry and study completion.
Results: Symptoms improved from baseline (30.6) to day 90 (35.1) (p<0.0001; +15%), consistent with testosterone replacement. TNG increased scores for effectiveness (+20%), convenience (+30%), and global satisfaction (+3%) as compared to their previous topical TTh. TThE patients reported ease of use, convenience, efficacy/effectiveness, and travel friendliness as “likes” of TNG therapy. Overall, 67.2% of patients agreed or strongly agreed that they preferred TNG over topical TTh and 59% sought a prescription to continue treatment with TNG.
Conclusions: Patients switching from topical TTh to TNG reported significant improvements in symptoms and patient satisfaction compared to their previous topical TTh. Patients also reported a significant improvement in convenience with TNG despite two to three times daily application. Preference, satisfaction, and convenience may translate to better treatment compliance.
Geregisseerd gebruik: praktische handvatten voor gecontroleerd gebruik bij verslaafden bij wie (duurzame) abstinentie geen reëel doel meer is
Authors: van Outsem Ron 
Published: February 2019

Directed Substance Use: practical guidelines for managed substance use in patients of Substance Use Disorders who are durably unable to attain any form of abstinence
In this article, a substance use management program is presented that is applicable to clients who lack any realistic prognosis of reaching any form of sustainable abstinence. The aim of this program is to optimize the client’s quality of life and safety, and to reduce the risk of criminal behavior. The concept of directed substance use is introduced and explained. Practical guidelines as to how directed substance use should be practiced are provided.
Complementarity as a Driver of Value in Business Intelligence and Analytics Adoption Processes
Authors: Moreno Valter , Vieira da Silva Felipe Elias Lobo , Ferreira Rodrigo , Filardi Fernando 
Published: March 2019

Objetivo: Os investimentos em Business Intelligence and Analytics (BIA) são cada vez mais essenciais para a competitividade das empresas. Apoiado na Visão Baseada em Recursos (VBR), este estudo analisou a implementação de um sistema de BIA no Banco Nacional de Desenvolvimento Econômico e Social (BNDES) para avaliar a geração de valor para a organização. Método: Coletamos dados qualitativos por meio de entrevistas, observação participante e em documentos internos e comunicações. A análise dos dados seguiu o processo usual de codificação, agregação e síntese, com auxílio do Atlas.ti, um software de análise de dados qualitativos. Originalidade: As abordagens tradicionais de avaliação de investimentos em Tecnologia da Informação (TI), especialmente no caso de sistemas de BIA, negligenciam a natureza dinâmica e as influências mútuas dos ativos e capacidades de TI e as capacidades sócio-organizacionais complementares, no processo de geração de valor para o negócio. Além disso, a Visão Baseada em Recursos tem sido pouco empregada no estudo do impacto de sistemas de BIA nas organizações. Resultados: Os resultados do estudo revelaram o papel fundamental desempenhado pelos recursos e capacidades organizacionais e de TI no processo de adoção de BIA, bem como a importância da dinâmica de complementaridade e seus resultados positivos. Contribuições teóricas: Nesta pesquisa, fornecemos evidências do potencial da VBR para elucidar as complexidades envolvidas no uso da TI para a geração de valor para o negócio sustentável, e, portanto, para explicar os diferentes resultados obtidos por organizações que adotam sistemas de BIA. Palavras-chave: Business Intelligence; Gestão de Tecnologia da Informação; Visão Baseada em Recursos; Valor de TI; Recursos Complementares.
Chia: Composição nutricional e benefícios para a saúde humana
Authors: Rocha Yana Maria Amaral , Da Silva Leonardo Patrick Enéas 
Published: March 2019

Objetivo: O objetivo deste estudo é descrever as principais caracterizações nutricionais da chia (Salvia hispanica L.) assim como os principais estudos clínicos, com significativo nível de evidência, que comprovem a recomendação de seu uso em humanos. Método: Foi realizada uma revisão bibliográfica através do banco de dados PUBMED de ensaios clínicos randomizados que utilizassem a Chia (Salvia hispanica) e desenvolvido um novo produto. Resultados: Pode-se observar a riqueza nutricional de sua composição e suas propriedades de hidratação uma percentagem considerável de mucilagem: 5-6% (m/m). Conclusão: O conjunto desses dados em humanos demonstram um potencial de uso da chia na dieta de forma a ajudar em distintos fatores associados as principais patologias que afetam a saúde humana na atualidade.
Safety and Tolerability of Lidocaine Infusions as a Component of Multimodal Postoperative Analgesia in Children
Authors: Lemming Katherine , Fang Gary , Buck Marcia L. 
Published: March 2019

OBJECTIVES Use of lidocaine as part of a multimodal approach to postoperative pain management has increased in adults; however, limited information is available regarding safety and tolerability in pediatrics. This study's primary objective was to evaluate the incidence of adverse effects related to lidocaine infusions in a sample of pediatric patients.
METHODS A retrospective analysis was conducted in pediatric patients receiving lidocaine infusion for the management of postoperative analgesia at the University of Virginia Health System.
RESULTS A total of 50 patients with 51 infusions were included in the final analysis. The median patient age was 14 years (range, 2–17 years). The most frequent surgeries were spinal fusion (30%), Nuss procedure for pectus excavatum (16%), and nephrectomy (6%). The mean ± SD starting rate was 13.6 ± 6.5 mcg/kg/min. The mean infusion rate during administration was 15.2 ± 6.3 mcg/kg/min, with 14.4 ± 6.2 mcg/kg/min at discontinuation. The mean length of therapy was 30.6 ± 22 hours. A total of 12 infusions (24%) were associated with adverse effects, primarily neurologic ones, including paresthesias in the upper extremities (10%) and visual disturbances (4%). The average time to onset was 16.2 ± 15.2 hours. Seven infusions were discontinued, whereas the remaining infusions resulted in either dose reduction or continuation without further incident. No patients experienced toxicity requiring treatment with lipid emulsion.
CONCLUSIONS In this sample, lidocaine was a well-tolerated addition to multimodal postoperative pain management in the pediatric population. Although adverse effects were common, they were mild and resolved with either dose reduction or discontinuation.
Telemedicin i akut patientbehandling – fra 112 opkald til akutafdeling
Authors: Raaber Nikolaj 
Published: February 2019

Afhandlingen undersøger ved tre interventionsstudier væsentlige problematikker i forhold til anvendelsen af telemedicinske løsninger med formål at optimere akutte patientforløb fra 112 opkald til modtagelsen af patienten i en akutafdeling. De tre telemedicinske modaliteter der blev anvendt er 1.) telekonsultation mellem ambulance og akutmedicinsk vagtcentral, 2.) transmission af prehospitale patientdata fra ambulancer til akutafdeling og 3.) visning geografisk informations system data for ambulancer i akutafdeling. Patientpopulationen spænder fra de potentielt mindst syge til de sværest syge og tilskadekomne og anvendelsen af telemedicin undersøges både kvantitativt og kvalitativt fra et rent sundhedsfagligt og organisatorisk perspektiv og fra patientperspektiv.
La compétence numérique de gestion des frontières sur les réseaux sociaux numériques : un capital culturel technologique à la Bourdieu
Authors: Ollier-Malaterre Ariane 
Published: March 2019

Certains réseaux sociaux numériques, comme Facebook, Twitter, Instagram ou Google+ par exemple, offrent la possibilité de se connecter à des contacts aussi bien professionnels que personnels, et de partager des informations (messages, photos, vidéos, etc.) relevant des deux domaines. Les cercles sociaux d’un individu, qui sont largement segmentés dans la vie courante, entrent ainsi en collision sur les réseaux sociaux numériques, avec des conséquences parfois très bénéfiques, et parfois très néfastes pour les relations interpersonnelles et pour les réputations professionnelles. Cet article propose une analyse conceptuelle de la gestion des frontières entre identités professionnelle et personnelle sur les réseaux sociaux numériques comme étant unecompétence numériqueet une forme decapital culturel technologiqueà la Bourdieu (1979). Dans un premier temps, l’article définit la gestion des frontières entre rôles et identités comme une compétence à part entière. Ensuite, il présente les spécificités des interactions médiées publiques sur les réseaux sociaux numériques par rapport aux interactions directes et aux interactions médiées privées ; ces spécificités impliquent que la compétence de gestion des frontières doit être transposée à la sphère numérique. L’article se poursuit en illustrant cette nouvelle compétence numérique par la présentation d’une typologie de quatre stratégies de gestion des frontières entre identités professionnelle et personnelle sur les réseaux sociaux numériques. Enfin, l’article analyse la compétence numérique de gestion des frontières en ligne comme une forme de capital culturel incorporé et, plus précisément, comme un capital culturel technologique qui agit en tant que capital symbolique permettant de construire et de développer le capital social d’un individu.
La formation continue numérisée face à ses discontinuités
Authors: Boboc Anca , Metzger Jean-Luc 
Published: March 2019

Dans un contexte caractérisé par la volonté d’accroître la responsabilisation individuelle des salariés dans l’acquisition et le maintien de leurs compétences professionnelles, l’utilisation du numérique apparaît aux yeux de certains décideurs comme une solution pertinente pour former leurs employés plus rapidement et en lien plus direct avec la stratégie des entreprises. Mais au-delà des principes séduisants, que montrent les expérimentations en cours ?
Pour apporter des éléments de réponse, nous nous appuyons dans cet article sur une enquête qualitative réalisée auprès des apprenants et des formateurs qui ont suivi — voire, pour certains, qui ont mis en place — une formation à distance entièrement numérisée (Corporate Open Online Courses ou COOC) au sein d’une grande entreprise. Nous pointons l’importance du taux d’abandon chez les apprenants, les difficultés des formateurs à exercer leur nouveau rôle d’animateur, et soulignons les discontinuités que la numérisation de la formation induit sur les espace-temps de travail et sur les interconnaissances professionnelles. Nous montrons également que ces discontinuités ont des effets différenciés sur les capacités d’apprentissage des salariés. Grâce à l’approche par les capacités d’Amartya Sen, nous interprétons ces constats en termes de facteurs de conversion (environnementaux, sociaux, individuels). Nous soutenons que c’est l’absence de ces trois catégories de facteurs qui explique, pour les apprenants et pour les formateurs, les discontinuités rencontrées et les inégalités dans la maîtrise des nouveaux dispositifs de formation. Enfin, nous esquissons des pistes pour repenser la numérisation de la formation continue, afin de réduire les risques d’inégalités sociales cristallisées autour de ce type de dispositifs technico-pédagogiques.
Mitochondrial complex activity in permeabilised cells of chronic fatigue syndrome patients using two cell types
Authors: Tomas Cara , Brown Audrey E. , Newton Julia L. , Elson Joanna L. 
Published: March 2019

Abnormalities in mitochondrial function have previously been shown in chronic fatigue syndrome (CFS) patients, implying that mitochondrial dysfunction may contribute to the pathogenesis of disease. This study builds on previous work showing that mitochondrial respiratory parameters are impaired in whole cells from CFS patients by investigating the activity of individual mitochondrial respiratory chain complexes. Two different cell types were used in these studies in order to assess individual complex activity locally in the skeletal muscle (myotubes) (n = 6) and systemically (peripheral blood mononuclear cells (PBMCs)) (controln = 6; CFSn = 13). Complex I, II and IV activity and respiratory activitysupported by fatty acid oxidation and glutaminolysis were measured usingextracellular flux analysis. Cells were permeabilised and combinations of substrates and inhibitors were added throughout the assays to allow states of mitochondrial respiration to be calculated and the activity of specific aspects of respiratory activity to be measured. Results showed there to be no significant differences in individual mitochondrial complex activity or respiratory activity supported by fatty acid oxidation or glutaminolysis between healthy control and CFS cohorts in either skeletal muscle (p ≥ 0.190) or PBMCs (p ≥ 0.065). This is the first study to use extracellular flux analysisto investigate individual mitochondrial complex activity in permeabilised cells in the context of CFS. The lack of difference in complex activity in CFS PBMCs suggests that the previously observed mitochondrial dysfunction in whole PBMCs is due to causes upstream of the mitochondrial respiratory chain.
Use of Next Generation Sequencing to study two cowpox virus outbreaks
Authors: Antwerpen Markus H. , Georgi Enrico , Nikolic Alexandra , Zoeller Gudrun , Wohlsein Peter , Baumgärtner Wolfgang , Peyrefitte Christophe , Charrel Remi , Meyer Hermann 
Published: March 2019

BackgroundBetween 2008 and 2011 about 40 cases of human cowpox were reported from Germany and France. Infections had been acquired via close contact to infected, young pet rats. An identical and unique sequence of the hemagglutinin gene was found in various cowpox virus (CPXV) isolates pointing to a common source of infection. In a second CPXV outbreak in cats in a small animal clinic in Germany in 2015, four out of five hospitalized cats showed identical hemagglutinin sequences and thus, a hospital-acquired transmission had been assumed. Next-Generation Sequencing was performed in order to re-investigate the outbreaks, as epidemiological data could not confirm all cases.MethodsHomogenates of lesion material from rats, cats and humans were cultivated in cell culture. The genomes of four virus isolates, nine CPXVs from our strain collections and from DNA of three paraffin-embedded lesion materials were determined by Next Generation Sequencing (NGS). For phylogenetic analyses a MAFFT-alignment was generated. A distance matrix based on concatenated SNPs was calculated and plotted as dendrogram using Unweighted Pair Group Method with Arithmetic mean (UPGMA) for visualization.ResultsAligning of about 200.000 nucleotides of 8 virus isolates associated with the pet rat outbreak revealed complete identity of six genomes, the remainder two genomes differed in as little as 3 SNPs. When comparing this dataset with four already published CPXV genomes also associated with the pet rat outbreak, again a maximum difference of 3 SNPs was found. The outbreak which lasted from 2008 till 2011 was indeed caused by a single strain which has maintained an extremely high level of clonality over 4 years. Aligning genomic sequences from four cases of feline cowpox revealed 3 identical sequences and one sequence which differed in 65 nucleotides. Although identical hemagglutinin sequences had been obtained from four hospitalized cats, genomic sequencing proved that a hospital-acquired transmission had occurred in only three cats.ConclusionAnalyzing the rather short sequence of the hemagglutinin gene is not sufficient to conduct molecular trace back analyses. Instead, whole genome sequencing is the method of choice which can even be applied to paraffin-embedded specimens.
Prevalence, Pattern and Correlates of Intimate Partner Violence among Married Men as Victims in Osogbo, Nigeria
Authors: Deborah Abiodun Adejoke , Olarewaju Sunday O. , Benjamin Abiodun Afolabi , Adunoye Adegbite Temilade 
Published: March 2019

Aim: The burden of intimate partner violence in men as victims is under explored in Nigeria and in the catchment area of the present study. The aim of this study was to determine the prevalence pattern and correlates of intimate partner violence among married men as victims in Osogbo metropolis.
Study Design: A descriptive cross-sectional study.
Place and Duration of Study: This study was carried out in Osogbo metropolis between October and December, 2017.
Methodology: The study was conducted among 300 consenting married men between the ages of 18 and 65 years in Osogbo metropolis. A multistage sampling technique was used. A questionnaire designed based on literature searches and also adapted from conflicts tactics scale was self-administered by the respondents. Data was entered into the computer and analysed using Statistical Package for Social Sciences (SPSS) version 21. Frequency distribution tables, charts and graphs were generated from variables while cross tabulation and test statistics were done where applicable. Chi square was used to compare rates, ratios and proportions while fisher’s exact test was used when cells had expected values less than 5. Logistic regression was used to avoid confounding effects. Level of significance was set with P-value less than .05.
Results: Majority of the respondents was currently in a monogamous relationship, employed and earns more than 1800 Naira minimum wage. More than half of the respondents had tertiary education and of Christian religion. The mean age of the respondents was 41.92±10.10 years. The prevalence of intimate partner violence was 31%, psychological abuse was 29.3%, physical abuse 14.7% while sexual abuse was 17%. The association between age of respondents, age of respondents’ wives, income less than wives’ and intimate partner violence was found to be statistically significant. Those whose wives were employed were 4.713 times more likely to have IPV and those who earn less than their wives’ were 2.442 times more likely to have IPV.
Conclusion: The prevalence of IPV was found to be high among married men. The results of this study have shown the burden of intimate partner violence among married men. This can serve as a baseline for planning intervention. This is also useful in providing part of a data base in Nigeria that may be important for advocating policy reviews.
Psychiatric pharmacist's role in overcoming barriers to clozapine use and improving management
Authors: Kelly Deanna L. , Love Raymond C. 
Published: March 2019

Abstract
Clozapine is an antipsychotic that exhibits superior efficacy and effectiveness for those with schizophrenia and other serious mental illness. However, its side-effect profile and administrative burdens present challenges to its use. In the United States, the medication is grossly underused even though it may improve outcomes and reduce costs. Current barriers to use include lack of prescriber knowledge and confidence, negative prescriber attitudes, special monitoring requirements, administrative factors, lack of clozapine on formularies, lack of support and infrastructure to use the medication within many health systems, and inadequate understanding or acknowledgement of clozapine prescribing and risks by policy makers and payers. Approaches using interprofessional models of care, which include pharmacists specializing in psychiatric care, can help meet the needs of patients receiving clozapine. This article lays out the big picture of barriers to clozapine and how psychiatric pharmacists could play a role in improving access.