bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Influence of Heat Acclimation and Hypohydration on Post-Weight-Loss Exercise Performance
Authors: Barley Oliver R. , Chapman Dale W. , Mavropalias Georgios , Abbiss Chris R. 
Published: May 2019

Purpose: To examine the influence of fluid intake on heat acclimation and the subsequent effects on exercise performance following acute hypohydration. Methods: Participants were randomly assigned to 1 of 2 groups, either able to consume water ad libitum (n = 10; age 23 [3] y, height 1.81 [0.09] m, body mass 87 [13] kg; HAW) or not allowed fluid (n = 10; age 26 [5] y, height 1.76 [0.05] m, body mass 79 [10] kg; HANW) throughout 12 × 1.5-h passive heat-acclimation sessions. Experimental trials were completed on 2 occasions before (2 baseline trials) and 1 following the heat-acclimation sessions. These sessions involved 3 h of passive heating (45°C, 38% relative humidity) to induce hypohydration followed by 3 h of ad libitum food and fluid intake after which participants performed a repeat sled-push test to assess physical performance. Urine and blood samples were collected before, immediately, and 3 h following hypohydration to assess hydration status. Mood was also assessed at the same time points. Results: No meaningful differences in physiological or performance variables were observed between HANW and HAW at any time point. Using pooled data, mean sprint speed was significantly (P < .001) faster following heat acclimation (4.6 [0.7] s compared with 5.1 [0.8] s). Furthermore, heat acclimation appeared to improve mood following hypohydration. Conclusions: Results suggest that passive heat-acclimation protocols may be effective at improving short-duration repeat-effort performance following acute hypohydration.
Ankle Sprains Risk Factors in a Sample of French Firefighters: A Preliminary Prospective Study
Authors: Vaulerin Jérôme , Chorin Frédéric , Emile Mélanie , d’Arripe-Longueville Fabienne , Colson Serge S. 
Published: May 2019

Context:Firefighters participating in mandatory physical exercise sessions are exposed to a high risk of ankle sprain injury. Although both physiological and psychological risk factors have been identified, few prospective studies considered the complex interaction of these factors in firefighters.Objective:To prospectively determine whether intrinsic physical risk factors and work-related environments predict ankle sprains occurring during on-duty physical exercise in firefighters during an 8-month follow-up period.Design:Prospective.Setting:Fire Department and Rescue Service.Participants:Thirty-nine firefighters were selected based on convenience sampling.Intervention:Participants performed physical tests and completed questionnaires.Main Outcome Measures:Lower Quarter Y-Balance Test, Weight-Bearing Lunge Test, anthropometric measures, postural stability, chronic ankle instability (Cumberland Ankle Instability Tool) scores, previous injuries, and perceived psychosocial work environment (Copenhagen Psychosocial Questionnaire [COPSOQ]).Results:During the follow-up, 9 firefighters sustained an injury. Lower Quarter Y-Balance Test and Weight-Bearing Lunge Test performances, Cumberland Ankle Instability Tool scores, history of previous ankle sprain, and specific dimensions of the COPSOQ significantly differed between injured and uninjured firefighters. Lower-limbs asymmetries of the Lower Quarter Y-Balance Test (ie, anterior, posteromedial, and posterolateral directions) and the Weight-Bearing Lunge Test were predictors of ankle sprains.Conclusions:These findings originally provide evidence that intrinsic factors mainly contribute to ankle sprains, although psychosocial work environment assessment could also characterize firefighters at risk.
Development and Validation of a Scale Assessing Test Anxiety in Physical Education
Authors: Danthony Sarah , Mascret Nicolas , Cury François 
Published: May 2019

Purpose: There is currently no scale assessing test anxiety in physical education (PE), despite the specificities of this class (e.g., body image, failure in front of peers). Accordingly, the aim of the present study was to develop a specific scale named the “Revised Test Anxiety and Regulatory Dimension of Anxiety in Physical Education” (RTAR-PE). Method: Self-report data were collected from 281 (Study 1) and 390 (Study 2) students in French schools (age range: 13–18 years). Results: Study 1 showed that the RTAR-PE scale has acceptable psychometric properties. Study 2 confirmed the results of Study 1 and showed the convergent, discriminant, and predictive validities of the scale. Gender differences were found, with girls showing higher PE test anxiety than boys. Discussion/Conclusion: The RTAR-PE is a newly available scale assessing the different facets of test anxiety in PE (worry, self-focus, bodily symptoms, somatic tension, and perceived control) considering the specificities of this class.
Environmental management for dengue control: a systematic review protocol
Authors: Mahmud Mohd Amierul Fikri , Abdul Mutalip Mohd Hatta , Lodz Noor Aliza , Muhammad Eida Nurhadzira , Yoep Norzawati , Hashim Mohd Hazrin , Paiwai Faizah , Rajarethinam Jayanthi , Aik Joel , Muhammad Nor Asiah 
Published: May 2019

IntroductionDengue is among the most important mosquito-borne diseases, with more than half of the world’s population at risk of infection in dengue endemic countries. Environmental management, which includes any activities that involve environmental modification, environmental manipulation and changes to human behaviour have been used to mitigate the risk of dengue transmission. In this protocol, we will integrate the data from various sources to assess the overall effect of environmental management on the incidence of dengue and other entomological indices.Methods and analysesWe will conduct a systematic review of intervention that assess the effect of environmental management on the incidence of dengue and/or entomological indices. We will include any studies that include intervention through environmental management for dengue control, involving environmental modification, environmental manipulation and changes to human behaviour. A comprehensive search will be performed in electronic databases PUBMED, CENTRAL, SCOPUS, Web of Science and relevant research websites such as PROPSERO, WHO ICTRP and ClinicalTrials.gov to identify studies that meet our inclusion criteria. A systematic approach to searching, screening, reviewing and data extraction will be applied based on Preferred Reporting Items for Systematic reviews and Meta-Analysis. Titles, abstract, keywords for eligibility will be examined independently by researchers. The quality of the included studies will be assessed using quality assessment tool for studies with diverse design and Cochrane risk of bias tool. The characteristics of the selected articles will be described based on the study design, types of intervention and outcomes of the study in various countries. These include the types of environmental management intervention methods and the effectiveness of the intervention in reducing dengue cases or incidence and impact on entomological indices.Ethics and disseminationWe will register this systematic review with the National Medical Research Register, Ministry of Health Malaysia. This protocol also had been registered with the PROSPERO. No ethical approval is necessary, as there will be no collection of primary data. The results will be disseminated though a peer-reviewed publication and conference presentation.Trial registration numberCRD42018092189.
Do hospital pressures change following rotavirus vaccine introduction? A retrospective database analysis in a large paediatric hospital in the UK
Authors: Heinsbroek Ellen , Hungerford Daniel , Cooke Richard P D , Chowdhury Margaret , Cargill James S , Bar-Zeev Naor , French Neil , Theodorou Eleni , Standaert Baudouin , Cunliffe Nigel A 
Published: May 2019

ObjectiveHospitals in the UK are under increasing clinical and financial pressures. Following introduction of childhood rotavirus vaccination in the UK in 2013, rotavirus gastroenteritis (RVGE) hospitalisations reduced significantly. We evaluated changes in ‘hospital pressures’ (demand on healthcare resources and staff) following rotavirus vaccine introduction in a paediatric setting in the UK.DesignRetrospective hospital database analysis between July 2007 and June 2015.SettingA large paediatric hospital providing primary, secondary and tertiary care in Merseyside, UK.ParticipantsHospital admissions aged <15 years. Outcomes were calculated for four different patient groups identified through diagnosis coding (International Classification of Disease, 10th edition) and/or laboratory confirmation: all admissions; any infection, acute gastroenteritis and RVGE.MethodsHospital pressures were compared before and after rotavirus vaccine introduction: these included bed occupancy, hospital-acquired infection rate, unplanned readmission rate and outlier rate (medical patients admitted to surgical wards due to lack of medical beds). Interrupted time-series analysis was used to evaluate changes in bed occupancy.ResultsThere were 116 871 admissions during the study period. Lower bed occupancy in the rotavirus season in the postvaccination period was observed for RVGE (−89%, 95% CI 73% to 95%), acute gastroenteritis (−63%, 95% CI 39% to 78%) and any infection (−23%, 95% CI 15% to 31%). No significant overall reduction in bed occupancy was observed (−4%, 95% CI −1% to 9%). No changes were observed for the other outcomes.ConclusionsRotavirus vaccine introduction was not associated with reduced hospital pressures. A reduction in RVGE hospitalisation without change in overall bed occupancy suggests that beds available were used for a different patient population, possibly reflecting a previously unmet need.Trials registration numberNCT03271593
Physician-identified barriers to and facilitators of shared decision-making in the Emergency Department: an exploratory analysis
Authors: Schoenfeld Elizabeth M , Goff Sarah L , Elia Tala R , Khordipour Errel R , Poronsky Kye E , Nault Kelly A , Lindenauer Peter K , Mazor Kathleen M 
Published: May 2019

ObjectivesShared decision-making (SDM) is receiving increasing attention in emergency medicine because of its potential to increase patient engagement and decrease unnecessary healthcare utilisation. This study sought to explore physician-identified barriers to and facilitators of SDM in the ED.MethodsWe conducted semistructured interviews with practising emergency physicians (EP) with the aim of understanding when and why EPs engage in SDM, and when and why they feel unable to engage in SDM. Interviews were transcribed verbatim and a three-member team coded all transcripts in an iterative fashion using a directed approach to qualitative content analysis. We identified emergent themes, and organised themes based on an integrative theoretical model that combined the theory of planned behaviour and social cognitive theory.ResultsFifteen EPs practising in the New England region of the USA were interviewed. Physicians described the following barriers: time constraints, clinical uncertainty, fear of a bad outcome, certain patient characteristics, lack of follow-up and other emotional and logistical stressors. They noted that risk stratification methods, the perception that SDM decreased liability and their own improving clinical skills facilitated their use of SDM. They also noted that the culture of the institution could play a role in discouraging or promoting SDM, and that patients could encourage SDM by specifically asking about alternatives.ConclusionsEPs face many barriers to using SDM. Some, such as lack of follow-up, are unique to the ED; others, such as the challenges of communicating uncertainty, may affect other providers. Many of the barriers to SDM are amenable to intervention, but may be of variable importance in different EDs. Further research should attempt to identify which barriers are most prevalent and most amenable to intervention, as well as capitalise on the facilitators noted.
IL23 induces IL23R recycling and amplifies innate receptor-induced signalling and cytokines in human macrophages, and the IBD-protective IL23R R381Q variant modulates these outcomes
Authors: Sun Rui , Hedl Matija , Abraham Clara 
Published: May 2019

ObjectiveThe interleukin (IL)23 pathway contributes to IBD pathogenesis and is being actively studied as a therapeutic target in patients with IBD. Unexpected outcomes in these therapeutic trials have highlighted the importance of understanding the cell types and mechanisms through which IL23 regulates immune outcomes. How IL23 regulates macrophage outcomes and the consequences of the IL23R R381Q IBD-protective variant on macrophages are not well defined; macrophages are key players in IBD pathogenesis and inflammation.DesignWe analysed protein and RNA expression, signalling and localisation in human monocyte-derived macrophages (MDMs) through western blot, ELISA, real-time PCR, flow cytometry, immunoprecipitation and microscopy.ResultsIL23R was critical for optimal levels of pattern-recognition receptor (PRR)-induced signalling and cytokines in human MDMs. In contrast to the coreceptor IL12Rβ1, IL23 induced dynamic IL23R cell surface regulation and this required clathrin and dynamin-mediated endocytosis and endocytic recycling-dependent pathways; these pathways were essential for IL23R-mediated outcomes. The IBD-protective IL23R R381Q variant showed distinct outcomes. Relative to IL23R R381, HeLa cells expressing IL23R Q381 showed decreased IL23R recycling and reduced assembly of IL23R Q381 with Janus kinase/signal transducer and activator of transcription pathway members. In MDMs from IL23R Q381 carriers, IL23R accumulated in late endosomes and lysosomes on IL23 treatment and cells demonstrated decreased IL23R- and PRR-induced signalling and cytokines relative to IL23R R381 MDMs.ConclusionMacrophage-mediated inflammatory pathways are key contributors to IBD pathogenesis, and we identify an autocrine/paracrine IL23 requirement in PRR-initiated human macrophage outcomes and in human intestinal myeloid cells, establish that IL23R undergoes ligand-induced recycling, define mechanisms regulating IL23R-induced signalling and determine how the IBD-protective IL23R R381Q variant modulates these processes.
CSF neurogranin as a neuronal damage marker in CJD: a comparative study with AD
Authors: Blennow Kaj , Diaz-Lucena Daniela , Zetterberg Henrik , Villar-Pique Anna , Karch Andre , Vidal Enric , Hermann Peter , Schmitz Matthias , Ferrer Abizanda Isidro , Zerr Inga , Llorens Franc 
Published: May 2019

ObjectiveTo investigate whether cerebrospinal fluid (CSF) neurogranin concentrations are altered in sporadic Creutzfeldt-Jakob disease (CJD), comparatively with Alzheimer’s disease (AD), and associated with neuronal degeneration in brain tissue.MethodsCSF neurogranin, total tau, neurofilament light (NFL) and 14-3-3 protein were measured in neurological controls (NCs, n=64), AD (n=46) and CJD (n=81). The accuracy of neurogranin discriminating the three diagnostic groups was evaluated. Correlations between neurogranin and neurodegeneration biomarkers, demographic, genetic and clinical data were assessed. Additionally, neurogranin expression in postmortem brain tissue was studied.ResultsCompared with NC, CSF neurogranin concentrations were increased in CJD (4.75 times of NC; p<0.001, area under curve (AUC), 0.96 (95% CI 0.93 to 0.99) and AD (1.94 times of NC; p<0.01, AUC 0.73, 95% CI 0.62 to 0.82), and were able to differentiate CJD from AD (p<0.001, AUC 0.85, 95% CI 0.78 to 0.92). CSF tau was increased in CJD (41 times of NC) and in AD (3.1 times of NC), both at p<0.001. In CJD, neurogranin positively correlated with tau (r=0.55, p<0.001) and was higher in 14-3-3-positivity (p<0.05), but showed no association with NFL (r=0.08, p=0.46). CJD-MM1/MV1 cases displayed higher neurogranin levels than VV2 cases. Neurogranin was increased at early CJD disease stages and was a good prognostic marker of survival time in CJD. In brain tissue, neurogranin was detected in the cytoplasm, membrane and postsynaptic density fractions of neurons, with reduced levels in AD, and more significantly in CJD, where they correlated with synaptic and axonal markers.ConclusionsNeurogranin is a new biomarker of prion pathogenesis with diagnostic and prognostic abilities, which reflects the degree of neuronal damage in brain tissue in a CJD subtype manner.
Neuroimaging selection for thrombectomy in pediatric stroke: a single-center experience
Authors: Lee Sarah , Heit Jeremy J , Albers Gregory W , Wintermark Max , Jiang Bin , Bernier Eric , Fischbein Nancy J , Mlynash Michael , Marks Michael P , Do Huy M , Dodd Robert L 
Published: May 2019

BackgroundThe extended time window for endovascular therapy in adult stroke represents an opportunity for stroke treatment in children for whom diagnosis may be delayed. However, selection criteria for pediatric thrombectomy has not been defined.MethodsWe performed a retrospective cohort study of patients aged <18 years presenting within 24 hours of acute large vessel occlusion. Patient consent was waived by our institutional IRB. Patient data derived from our institutional stroke database was compared between patients with good and poor outcome using Fisher’s exact test, t-test, or Mann-Whitney U-test.ResultsTwelve children were included: 8/12 (66.7%) were female, mean age 9.7±5.0 years, median National Institutes of Health Stroke Scale (NIHSS) 11.5 (IQR 10–14). Stroke etiology was cardioembolic in 75%, dissection in 16.7%, and cryptogenic in 8.3%. For 2/5 with perfusion imaging, Tmax >4 s appeared to better correlate with NIHSS. Nine patients (75%) were treated: seven underwent thrombectomy alone; one received IV alteplase and thrombectomy, and one received IV alteplase alone. Favorable outcome was achieved in 78% of treated patients versus 0% of untreated patients (P=0.018). All untreated patients had poor outcome, with death (n=2) or severe disability (n=1) at follow-up. Among treated patients, older children (12.8±2.9 vs 4.2±5.0 years, P=0.014) and children presenting as outpatient (100% vs 0%, P=0.028) appeared to have better outcomes.ConclusionsPerfusion imaging is feasible in pediatric stroke and may help identify salvageable tissue in extended time windows, though penumbral thresholds may differ from adult values. Further studies are needed to define criteria for thrombectomy in this unique population.
Neutrino mass matrix in a gauge group SU(2)L × U(1)e × U(1)μ × U(1)τ
Authors: Fayyazuddin  
Published: May 2019

The electroweak unification group [Formula: see text] in which each fermion multiplet has its own [Formula: see text] factor was proposed in 1986 to get the neutrino mass matrix. In this paper, the gauge group [Formula: see text] is restricted to lepton section only, leaving quark multiplets as in the Standard Model. In addition to lepton multiplets [Formula: see text], [Formula: see text] and [Formula: see text], there are three [Formula: see text] singlet right-handed neutrinos [Formula: see text]’s. With the breaking of [Formula: see text] to [Formula: see text], the right-handed neutrinos acquire heavy Majorana masses. Three heavy right-handed neutrinos [Formula: see text]’s are available to generate a [Formula: see text] nondiagonal neutrino mass matrix in terms of three Yukawa couplings [Formula: see text], [Formula: see text], [Formula: see text] of the Higgs scalar doublet to [Formula: see text], [Formula: see text], [Formula: see text] with [Formula: see text], [Formula: see text] and [Formula: see text], respectively. Three Yukawa couplings can be arranged and expressed in terms of masses [Formula: see text], [Formula: see text], [Formula: see text] in three different ways to obtain the results of interest for Case 1: [Formula: see text]; Case 2: [Formula: see text]; Case 3: [Formula: see text]. The results obtained for the three cases are compared with the experimental data from neutrino oscillations. Cases 1 and 2 are relevant for solar neutrino oscillations whereas Case 3 is relevant for atmospheric neutrino oscillations.
SIGKDD Impact Program 2018
Authors: Sosič Rok , Ghani Rayid , Leskovec Jure 
Published: May 2019

The SIGKDD Impact Program was established in 2017. As the SIGKDD community has expanded its reach dramati- cally over the past few years and the KDD conference has grown into a major global event, the aim for the social im- pact program is to focus the power of the community to- wards a broader positive societal impact.
The goal of this program was to support projects that pro- mote data science, increase its impact on society, and help the data science community. The project duration was lim- ited to one year. The total amount of funding provided by the SIGKDD Impact Program in 2018 was $250k, given as unrestricted gifts.
Projects funded in 2018 were required to present a mid- project update of their work and outcomes at the KDD 2018 conference in London in August 2018.
Diurnal repeated exercise promotes slow-wave activity and fast-sigma power during sleep with increase in body temperature: a human crossover trial
Authors: Aritake-Okada Sayaka , Tanabe Kosuke , Mochizuki Yoshiko , Ochiai Ryuji , Hibi Masanobu , Kozuma Kazuya , Katsuragi Yoshihisa , Ganeko Masashi , Takeda Noriko , Uchida Sunao 
Published: May 2019

The effects of exercise on sleep have been explored from various perspectives, but little is known about how the effects of acute exercise on sleep are produced through physiological functions. We used a protocol of multiple daytime sessions of moderate-intensity aerobic exercise and examined the subsequent effects on sleep structure, core body temperature (CBT), distal-proximal skin temperature gradient (DPG), and subjective parameters. Fourteen healthy men who did not exercise regularly were evaluated under the baseline (no exercise) and exercise conditions on a within-subject crossover basis. Under the exercise condition, each participant performed a 40-min aerobic workout at 40% of maximal oxygen intake, four times between morning and early evening. We observed a 33% increase in slow-wave sleep (SWS; P = 0.005), as well as increases in slow-wave activity (SWA; P = 0.026), the fast-sigma power/SWA ratio ( P = 0.005), and subjective sleep depth and restorativeness the following morning. Moreover, both CBT and the DPG increased during sleep after exercise ( P = 0.021 and P = 0.047, respectively). Regression analysis identified an increased nocturnal DPG during sleep after exercise as a factor in the increase in SWA. The fast-sigma/SWA ratio correlated with CBT. The performance of acute exercise promotes SWS with nocturnal elevation in the DPG. Both CBT and fast-sigma power may play a role in the specific physiological status of the body after exercise.NEW & NOTEWORTHY We used multiple daytime sessions of moderate-intensity aerobic exercise to examine the effects on the sleep structure, core body temperature (CBT), distal-proximal skin temperature gradient (DPG), and subjective parameters. Significant increases in slow-wave activity (SWA), CBT, DPG, fast-sigma power, and subjective parameters were observed during the night and the following morning. Nocturnal DPG is a factor in the increased SWA.