bluuebunny/crossref_metadata_2025_split huggingface dataset:
Arterial Properties as Determinants of Left Ventricular Mass and Fibrosis in Severe Aortic Stenosis: Findings From ACRIN PA 4008
Authors: Chirinos Julio A. , Akers Scott R. , Schelbert Erik , Snyder Bradley S. , Witschey Walter R. , Jacob Ron M. , Jamis‐Dow Carlos , Ansari Bilal , Lee Jonathan , Segers Patrick , Schnall Mitchell , Cavalcante João L. 
Published: December 2018

Background

The role of arterial load in severe aortic stenosis is increasingly recognized. However, patterns of pulsatile load and their implications in this population are unknown. We aimed to assess the relationship between the arterial properties and both (1) left ventricular remodeling and fibrosis and (2) the clinical course of patients with severe aortic stenosis undergoing aortic valve replacement (
AVR
).

Methods and Results

We enrolled 38 participants with symptomatic severe aortic stenosis scheduled to undergo surgical
AVR
. Aortic root characteristic impedance, wave reflections parameters (reflection magnitude, reflected wave transit time), and myocardial extracellular mass were measured with cardiac magnetic resonance imaging and arterial tonometry Cardiac magnetic resonance imaging was repeated at 6 months in 30 participants. A reduction in cellular mass (133.6 versus 113.9 g;
P
=0.002) but not extracellular mass (42.3 versus 40.6 g;
P
=0.67) was seen after
AVR
. Participants with higher extracellular mass exhibited greater reflection magnitude (0.68 versus 0.54;
P
=0.006) and lower aortic root characteristic impedance (56.3 versus 96.9 dynes/s per cm
5
;
P
=0.006). Reflection magnitude was a significant predictor of smaller improvement in the quality of life (Kansas City Cardiomyopathy Questionnaire score) after
AVR
(
R
=−0.51;
P
=0.0026). The 6‐minute walk distance at 6 months after
AVR
was positively correlated with the reflected wave transit time (
R
=0.52;
P
=0.01).

Conclusions

Consistent with animal studies, arterial wave reflections are associated with interstitial volume expansion in severe aortic stenosis and predict a smaller improvement in quality of life following
AVR
. Future trials should assess whether wave reflections represent a potential therapeutic target to mitigate myocardial interstitial remodeling and to improve the clinical status of this patient population.
eHealth Tools to Provide Structured Assistance for Atrial Fibrillation Screening, Management, and Guideline‐Recommended Therapy in Metropolitan General Practice: The AF‐SMART Study
Authors: Orchard Jessica , Neubeck Lis , Freedman Ben , Li Jialin , Webster Ruth , Zwar Nicholas , Gallagher Robyn , Ferguson Caleb , Lowres Nicole 
Published: December 2018

Background

This
eH
ealth implementation study aimed to evaluate strategies to promote opportunistic atrial fibrillation (
AF
) screening using electronic screening prompts and improve treatment using electronic decision support (
EDS
) software.

Methods and Results

An electronic screening prompt appeared whenever an eligible patient's (aged ≥65 years, no
AF
diagnosis) medical record was opened in participating general practices. General practitioners and practice nurses offered screening using a smartphone ECG, with validated
AF
algorithm. Guideline‐based
EDS
was provided to assist treatment decisions. Deidentified data were collected from practices using a data extraction tool. General practices (n=8) across Sydney, Australia, screened for a median of 6 months. A total of 1805 of 11 476 (16%) eligible patients who attended were screened (44% men, mean age 75.7 years). Screening identified 19 (1.1%) new cases of
AF
(mean age, 79 years; mean
CHA
2
DS
2
‐
VAS
c, 3.7; 53% men). General practitioners (n=30) performed 70% of all screenings (range 1–448 patients per general practitioner). The proportion of patients with AF who had
CHA
2
DS
2
‐
VAS
c ≥2 for men or ≥3 for women prescribed oral anticoagulants was higher for those diagnosed during the study: 15 of 18 (83%) for screen‐detected and 39 of 46 (85%) for clinically detected, compared with 933 of 1306 (71%) patients diagnosed before the study (
P
<0.001). The
EDS
was accessed 111 times for patients with
AF
and for 4 of 19 screen‐detected patients.

Conclusions

The
eH
ealth tools showed promise. Adherence to guideline‐based oral anticoagulant prescription was significantly higher in patients diagnosed during the study period, although the
EDS
was only used in a minority. While the proportion of eligible patients screened and
EDS
use was relatively low, further refinements may improve uptake in clinical practice.

Clinical Trial Registration

URL
:
www.anzctr.org.au
. Unique identifier:
ACTRN
12616000850471.
A Latent Variable Model Approach to PMI-based Word Embeddings
Authors: Arora Sanjeev , Li Yuanzhi , Liang Yingyu , Ma Tengyu , Risteski Andrej 
Published: December 2018

Semantic word embeddings represent the meaning of a word via a vector, and are created by diverse methods. Many use nonlinear operations on co-occurrence statistics, and have hand-tuned hyperparameters and reweighting methods. This paper proposes a new generative model, a dynamic version of the log-linear topic model of Mnih and Hinton (2007). The methodological novelty is to use the prior to compute closed form expressions for word statistics. This provides a theoretical justification for nonlinear models like PMI, word2vec, and GloVe, as well as some hyperparameter choices. It also helps explain why low-dimensional semantic embeddings contain linear algebraic structure that allows solution of word analogies, as shown by Mikolov et al. (2013a) and many subsequent papers. Experimental support is provided for the generative model assumptions, the most important of which is that latent word vectors are fairly uniformly dispersed in space.
Exploring Compositional Architectures and Word Vector Representations for Prepositional Phrase Attachment
Authors: Belinkov Yonatan , Lei Tao , Barzilay Regina , Globerson Amir 
Published: December 2018

Prepositional phrase (PP) attachment disambiguation is a known challenge in syntactic parsing. The lexical sparsity associated with PP attachments motivates research in word representations that can capture pertinent syntactic and semantic features of the word. One promising solution is to use word vectors induced from large amounts of raw text. However, state-of-the-art systems that employ such representations yield modest gains in PP attachment accuracy. In this paper, we show that word vector representations can yield significant PP attachment performance gains. This is achieved via a non-linear architecture that is discriminatively trained to maximize PP attachment accuracy. The architecture is initialized with word vectors trained from unlabeled data, and relearns those to maximize attachment accuracy. We obtain additional performance gains with alternative representations such as dependency-based word vectors. When tested on both English and Arabic datasets, our method outperforms both a strong SVM classifier and state-of-the-art parsers. For instance, we achieve 82.6% PP attachment accuracy on Arabic, while the Turbo and Charniak self-trained parsers obtain 76.7% and 80.8% respectively.
Accelerating studies on the ontogeny and morphological diversity in immature mites
Authors: ZHANG ZHI-QIANG 
Published: December 2018

Over 58,000 species of mites have been described (Zhang 2011; Liu et al. 2013). Most species of mites are known only as adults, although immature instars also present a diversity of characters and other information potentially useful for understanding mite taxonomy, phylogeny and biology. A recent overview of juvenile instars of oribatid mites (excluding Astigmata) shows that only about 8% of the known oribatid mites have one or more juvenile instars described (Norton & Ermilov 2014). A survey of papers published during the last three years (2015–2017) in five main acarological journals (Acarina, Acarologia, International Journal of Acarology, Persian Journal of Acarology, Systematic and Applied Acarology) and two other main zoological journals (Zootaxa and ZooKeys) with mite papers showed only 3% to 19% of these with descriptions of immatures, but among the 151 species included in these papers as many as 61% have full data on the ontogeny (Liu & Zhang 2018).
Triangulated perspectives on outcomes of pulmonary rehabilitation in patients with COPD: a qualitative study to inform a core outcome set
Authors: Souto-Miranda Sara , Marques Alda 
Published: December 2018

Introduction: Pulmonary rehabilitation implies a comprehensive assessment. Although several outcomes are commonly measured, those are selected mainly by health professionals and researchers, with the voice of patients and informal caregivers being minimally captured. Qualitative studies are fundamental to enhance our knowledge on perspectives of different stakeholders involved in pulmonary rehabilitation. Objective: This study aimed to explore the views of different stakeholders on outcomes of pulmonary rehabilitation, contributing to one of the stages of a core outcome set for pulmonary rehabilitation in patients with chronic obstructive pulmonary disease (COPD). Methods: Semi-structured interviews were conducted with 12 patients with COPD, 11 informal carers and 10 health professionals. Data were analysed with content analysis, followed by thematic analysis to gain deeper understanding of the different perspectives. Results: A total of 44 outcomes were identified, being the most reported ‘improving functional performance’ (67%) and ‘reducing and taking control over dyspnoea’ (64%). Five relevant themes across stakeholders were generated: having a healthy mind in a healthy body; I can(’t) do it; feeling fulfilled; knowing more, doing better and avoiding doctors and expenses. Although perspectives were mostly consensual, some outcomes were only valued by health professionals (e.g. pulmonary function) or by patients and informal carers (e.g. quality of sleep). Conclusion: Views of the different stakeholders on outcomes of pulmonary rehabilitation were similar although, some specificities existed. Comprehensive assessments are needed to reflect what is valued by the different stakeholders in pulmonary rehabilitation. This study contributed to a future core outcome set in this field.
Clinical and radiological outcomes of acetabular revision with the Delta Revision TT cup
Authors: Munegato Daniele , Bigoni Marco , Sotiri Romeo , Bruschetta Antongiulio , Omeljaniuk Robert J , Turati Marco , Andrea Rossi , Zatti Giovanni 
Published: December 2018

Introduction: This study evaluates mid-term results of acetabular revision using a hemispherical acetabular cup in Trabecular Titanium with a cage construct. Methods: We reviewed 36 acetabular revisions performed with the Delta Revision TT cup in 34 patients (mean age = 75, range: 45–92 years). Acetabular defect types (Paprosky classification) included (1) 2B ( n = 5), (2) 2C ( n = 7), (3) 3A ( n = 15), and (4) 3B ( n = 9). Morcellised bone allografts were used in 24 cases, and synthetic bone used in 11. Outcomes were evaluated using the Harris Hip Score (HHS), and the Verbal Rating Scale (VRS) for pain measurement. X-ray visualisation of cup position was used to discern signs of mobilisation and bone graft incorporation. Survivorship at post-revision follow-up (mean = 39.8; range 12–91.5 months) was calculated. Results: HHS increased from 40.5 to 87 ( p < 0.01). 68% of cases were pain free; by comparison, 32% had an average VRS score of 1.9 (range 1–3). The average cup inclination angle was 40.8° (30–52°) postoperatively, compared with 41.2° (30–52°) at follow-up; there were no signs of loosening or mobilisation. Centre of rotation was fully restored in 21 (58.3%) hips. According to Gie classification; bone graft incorporation grades were (1) 3 ( n = 21), (2) 2 ( n = 12) and (3) 1 ( n = 2). The survival rate was 100% for aseptic loosening and 91.7% for any cause of revision. Conclusions: The Delta Revision TT cup promises good clinical and radiographic results at short- to mid-term follow-up, with high rates of survival rate and bone integration.
Isolated Meniscal Suture. Follow Up and Return to Sports. Our experience
Authors: Jalil Andrés M. , Ferreyra Cristian A. , Balla Mauricio , Mancini Pablo S. , Borsani Gino 
Published: December 2018

The meniscal rupture is the lesion with the most frequent surgical indication of the knee. The meniscus intervenes in joint physiology in different ways: transmitting and distributing loads, joint lubrication, proprioception and, participating in joint stability. Meniscal resection has deleterious effects on the joint, rapidly causing degenerative changes and poor long-term results. You should try to preserve as much of the meniscus as possible, either with partial meniscectomies, or if the injury allows it, repair. Objectives: evaluate, in the short and medium term, athletes with meniscal injury, young adults, who underwent meniscal suture. The results were analyzed, trying to identify the linked variables. Methods: Retrospective, observational, descriptive study. In this case series, we evaluated 14 meniscal sutures. The Tegner Score and the Lysholm Test, both pre- and postsurgical, were used to assess the evolution of the patient and his return to sports activity at the time of medical discharge. Results: Meniscal suture: average number of points that was made in each meniscus was 3.5 stitches. The failure rate of 7%. The rest all returned to their pre-injury physical activity without pain. Improvement of the scores of Tegner and Lysholm. Conclusion: We can affirm that the meniscal suture presents a high percentage of healing with a minimum failure rate, and that the good results of the technique allow the patient to resume their competitive and recreational sports activities at the same pre-occupational level, with a high degree of satisfaction.
Plasma Agouti-Related Protein and Cortisol Levels in Cushing Disease: Evidence for the Regulation of Agouti-Related Protein by Glucocorticoids in Humans
Authors: Page-Wilson Gabrielle , Peters Jane B , Panigrahi Sunil K , Jacobs Thomas P , Korner Judith , Otten Marc , Bruce Jeffrey N , Wardlaw Sharon L 
Published: December 2018

AbstractContextGlucocorticoids regulate energy balance, in part by stimulating the orexigenic neuropeptide agouti-related protein (AgRP). AgRP neurons express glucocorticoid receptors, and glucocorticoids have been shown to stimulate AgRP gene expression in rodents.ObjectiveWe sought to determine whether there is a relationship between plasma AgRP and hypothalamic AgRP in rats and to evaluate the relationship between cortisol and plasma AgRP in humans.MethodsWe retrospectively evaluated plasma AgRP levels prior to transsphenoidal surgery in 31 patients with Cushing disease (CD) vs 31 sex- and body mass index–matched controls from a separate study. We then prospectively measured plasma AgRP, before and 6 to 12 months after surgery, in a subgroup of 13 patients with CD. Plasma and hypothalamic AgRP were measured in adrenalectomized rats with and without corticosterone replacement.ResultsPlasma AgRP was stimulated by corticosterone in rats and correlated with hypothalamic AgRP expression. Plasma AgRP levels were higher in patients with CD than in controls (139 ± 12.3 vs 54.2 ± 3.1 pg/mL; P &lt; 0.0001). Among patients with CD, mean 24-hour urine free cortisol (UFC) levels were 257 ± 39 μg/24 hours. Strong positive correlations were observed between plasma AgRP and UFC (r = 0.76; P &lt; 0.0001). In 11 of 13 patients demonstrating surgical cure, AgRP decreased from 126 ± 20.6 to 62.5 ± 8.0 pg/mL (P &lt; 0.05) postoperatively, in parallel with a decline in UFC.ConclusionsPlasma AgRP levels are elevated in CD, are tightly correlated with cortisol concentrations, and decline with surgical cure. These data support the regulation of AgRP by glucocorticoids in humans. AgRP’s role as a potential biomarker and as a mediator of the adverse metabolic consequences of CD deserves further study.
RIFUGI DEL BENE. RIFUGI DEL MALE. IL TENTATIVO DI SALVEZZA DI ANNA MARIA ORTESE.
Authors: Bubba Angela 
Published: December 2018

Una delle più grandi scrittrici del Novecento, Anna Maria Ortese, visse la tua intera esistenza all’insegna di una voluta distanza dal mondo, una lontananza che tuttavia non era una semplice estraneità da ciò che più la turbava, ma al contrario un punto di osservazione privilegiato da cui indagare e comprendere i nostri tempi. Non un nascondiglio ma un riparo attivo, un rifugio lucido e penetrante dove studiare il dolore della realtà. Seguendo le sue pubblicazioni, e privilegiando l’immagine del nativo americano, della natura e degli animali, emblemi massimi della sensibilità ortesiana, l’articolo esporrà i punti salienti della poetica dell’autrice, sempre tendente a recuperare i misteri del mondo, a scegliere un rifugio e all’interno di questo combattere, per la salvezza propria e altrui.
Development Strategy of National Microsatellite Industry: Case Study of Indonesia
Authors: Judianto Chusnul Tri , Harianto Harianto , Maulana Agus 
Published: December 2018

<p>Indonesia has larges archipelagic in the world, 13,466 islands with land area of 1,922,570 km<sup>2</sup> and water area of 3,257,483 km<sup>2</sup>. Controlling and monitoring the huge area of Indonesia using satellite technology is a possible way to do and self reliance of space technology is the way to maintain satellite data security. Remote sensing data, telematics and communication were needed for many applications for people and industry. Development of satellite technology for developing country can be done since the utility of the Mechanical and Electronic Miniaturization System (MEMS) and Component of The Self (COTS) meet the microsatellite basic technology requirement. Indonesia has experience on microsatellite research for surveillance, remote sensing, ships monitoring and science through National Institute of aeronautics and Space (LAPAN). Sustainability of the microsatellite technology mastery need support from government regulation, commercial cooperation with private company and collaboration research with university for space technology innovation. By using the SWOT and Quantitative Strategic Planning Matrix (QSPM) method, this research identify and analyze the alternative strategy from external and internal factors and selects the appropriate and precise strategy for developing the microsatellite industry. The research shows that standardization of satellite system, product, metod, human resources and financial support with new investor using Public Private Partnership schemes as well as utilization of international cooperation with other country are the entrance for space industry.</p><p> </p><p>Keywords: Microsatellite, COTS, MEMS, QSPM</p>
Technology-Based Startup: A Formula to Become Sustainable Company in Indonesia, A Case Study From UAVINDO Nusantara
Authors: Dzakiy Uruqul Nadhif 
Published: December 2018

<p>Beside technology-based startups are not many enough in Indonesia, they must have faced problems that make them hard to grow. Not many of them can sustain for a long time. UAVINDO Nusantara is an exception. The company that concern in Unmanned Aerial Vehicle (UAV) technology was founded in 2000 and can survive till now. It passed three periods (building trust, crisis, and rising up) before commits to be a solution provider company in aeronotics that concern in military market. Its change capability of organizational management, its innovation culture, and ability to become trusted company are characteristics for the company to become sustainable. Three factors that shape it like that ; leadership of its manager (director), learning culture inside the company, and ability to maintain its network.</p><p> </p>Keywords: UAVINDO Nusantara, technology-based startup, Indonesian company, sustainable company.
ANTIMICROBIAL ACTIVITY OF MEDICINAL PLANT EXTRACTS ANDROMEDA POLYFOLIA AND ALCHEMILLA SUBCRENATA
Authors: Живетьев (Zhivetyev) Максим (Maksim) Аркадьевич (Arkad'yevich) , Быбин (Bybin) Виктор (Viktor) Александрович (Aleksandrovich) , Кочерыгина (Kocherygina) Елена (Elena) Викторовна (Viktorovna) , Семенова (Semenova) Наталья (Natal'ya) Викторовна (Viktorovna) , Путилина (Putilina) Татьяна (Tat'yana) Егоровна (Egorovna) , Дударева (Dudareva) Любовь (Lyubov') Виссарионовна (Vissarionovna) , Граскова (Graskova) Ирина (Irina) Алексеевна (Аlekseevna) , Маркова (Markova) Юлия (Yuliya) Александровна (Aleksandrovna) 
Published: December 2018

Plants accumulate in their tissues powerful arsenal of protective substances necessary for survival in the face of abiotic environmental and in aggressive neighborhood with pathogenic bacteria and viruses. We examined the following kinds of medicinal plants: Alchemilla subcrenata and Polyfolia andromeda. Conducted chemical analyses of water and 40 and 70% alcohol extracts of these plants. The content of flavonoids was significantly greater in all ways of extraction of Alchemilla subcrenata compared to Andromeda polyfolia. To the extent the release of phenolic compounds and water-soluble sugars affected the presence of alcohol. From Andromeda polyfolia greater variety of phenolic compounds left in the water and 40% alcohol, and from Alchemilla subcrenata in 40% and 70% ethanol. Extracts compared on the effects on survival and biofilm formation of Escherichia coli XL1-Blue and Pectobacterium carotovorum. Found that extracts of plants studied have varying degrees of antimicrobial action. Alcohol extracts of Andromeda polyfolia suppressed the formation of biofilms of P. carotovorum and E. coli. All extracts of Alchemilla subcrenata stimulated bacterial growth and biofilm formation. The most effective proved to be 70% alcoholic extract of Alchemilla subcrenata.
PROPERTIES OF THE REFINER MECHANICAL PULP FROM FLAX SHIVE
Authors: Марченко (Marchenko) Роман (Roman) Александрович (Aleksandrovich) , Чендылова (Chendylova) Лариса (Larisa) Валерьевна (Valer'yevna) , Каретникова (Karetnikova) Наталья (Natal'ya) Викторовна (Viktorovna) , Пен (Pen) Роберт (Robert) Зусьевич (Zus'yevich) , Алашкевич (Alashkevich) Юрий (Yuriy) Давыдович (Davydovich) 
Published: December 2018

Flax shive is a large-tonnag by-product at the conversion linen in textile industry. The pulp from shive can be used as raw material for making to the paper-board production. The existing methods of delignification, because of difficulty of the technologi-cal cycle and of the ecological problems, reduce to minimum those economic advantages, which assume the low cost of the raw material. By that is conditioned interest to produce pulp without using of the chemicals.
Paper-make characteristics of the mixtures of waste-paper and rafiner mechanical pulp (RMP) from flax shive, hard wood, wheat straw were studied. The components ratio varied according to simplex-lattice plan of the experiment. The characteristic de-pendencies from composition of the mixtures are approximated by regression equation and are presentated as isolines in barycen-tric coordinates. It is determined that because of unsatisfactory strength properties RMP from flax shive can be not used, as inde-pendent fibrous half-finished product. Possible its using in mixture with waste-paper for produce of the product with the low re-quirements to the strength properties (for instance, some type of the sanitary-hygienic purpose paper).