bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prosthetic fungal infections
Authors: Sidhu M. S. , Cooper G. , Jenkins N. , Jeys L. , Parry M. , Stevenson J. D. 
Published: April 2019

Aims The aims of this study were to report the efficacy of revision surgery for patients with co-infective bacterial and fungal prosthetic joint infections (PJIs) presenting to a single institution, and to identify prognostic factors that would guide management. Patients and Methods A total of 1189 patients with a PJI were managed in our bone infection service between 2006 and 2015; 22 (1.85%) with co-infective bacterial and fungal PJI were included in the study. There were nine women and 13 men, with a mean age at the time of diagnosis of 64.5 years (47 to 83). Their mean BMI was 30.9 kg/m2 (24 to 42). We retrospectively reviewed the outcomes of these PJIs, after eight total hip arthroplasties and 14 total knee arthroplasties. The mean clinical follow-up was 4.1 years (1.4 to 8.8). Results The median number of risk factors for PJI was 5.5 (interquartile range (IQR) 3.25 to 7.25). All seven patients who initially underwent debridement and implant retention (DAIR) had a recurrent infection that led to a staged revision. All 22 patients underwent the first of a two-stage revision. None of the nine patients with negative tissue cultures at the second stage had a recurrent infection. The rate of recurrent infection was significantly higher in the presence of multidrug-resistant bacteria (p = 0.007), a higher C-reactive protein (CRP) at the time of presentation (p = 0.032), and a higher number of co-infective bacterial organisms (p = 0.041). The overall rate of eradication of infection after two and five years was 50% (95% confidence interval (CI) 32.9 to 75.9) and 38.9% (95% CI 22.6 to 67), respectively. Conclusion The risk of failure to eradicate infection with the requirement of amputation associated with this diagnosis is much higher than in patients with PJI without bacterial and fungal co-infection, and this risk is heightened when the fungal organism is joined by polymicrobial and multidrug-resistant bacterial organisms. Cite this article: Bone Joint J 2019;101-B:582–588.
Mapping the contact area of the patellofemoral joint
Authors: Clark D. , Stevens J. M. , Tortonese D. , Whitehouse M. R. , Simpson D. , Eldridge J. 
Published: April 2019

AimsThe aim of this study was to determine and compare the congruency of the articular surface contact area of the patellofemoral joint (PFJ) during both active and passive movement of the knee with the use of an MRI mapping technique in both the stable and unstable PFJ.Patients and MethodsA prospective case-control MRI imaging study of patients with a history of PFJ instability and a control group of volunteers without knee symptoms was performed. The PFJs were imaged with the use of an MRI scan during both passive and active movement from 0° through to 40° of flexion. The congruency through measurement of the contact surface area was mapped in 5-mm intervals on axial slices. In all, 40 patients were studied. The case group included 31 patients with symptomatic patellofemoral instability and the control group of nine asymptomatic volunteers. The ages were well matched between the case and control groups. The mean age was 25 years (16 to 42; sd 6.9) in the case group and 26 years (19 to 32; sd 5.1) in the control group. There were 19 female and 12 male patients in the case group.ResultsThe unstable PFJs were demonstrably less congruent than the stable PFJs throughout the range of knee movement. The greatest mean differences in congruency between unstable and stable PFJ’s were observed between 11° and 20° flexion (1.73 cm2vs 4.00 cm2; p < 0.005).ConclusionThe unstable PFJ is less congruent than the stable PFJ throughout the range of knee movement studied. This approach to mapping PFJ congruency produces a measurable outcome and will allow the assessment of pre- and postoperative results following surgical intervention. This may facilitate the design of new procedures for patients with PFJ instability. If a single axial series is to be obtained on MRI scan, the authors recommend 11° to 20° of tibiofemoral flexion, as this was shown to have the greatest difference in contact surface area between the case and control groups. Cite this article: Bone Joint J 2019;101-B:552–558.
Increasing Population (μ + λ)-CMA-ES with Centre and Elitism (IPOP!+)
Authors: Wineberg Mark , Opawale Samuel 
Published: April 2019

Elitism has previously been introduced to the CMA-ES family of algorithms, where the “’,’ selection operator is replaced by the “+” selection operator. Here we investigate in detailed the addition of elitism to IPOP. Furthermore, a new selection operator was added: the “!” operator (pronounced “bang” or “here”). This operator includes the results of ES recombination into the population for selection, unmodified by mutation, and evaluated separately. From the analysis, we noticed a remarkable improvement in the behavior of IPOP with or without elitism. Only one function (Levy) proved difficult when elitism was used. Under close examination, it was determined that for this function, the population under elitism converges prematurely, and stalled out. Currently we do not know what is the cause of this difference. Perhaps in the future this effect could be avoided or detected and remedial measures applied.
Stochastic Integer Waste Management Problem Solved by a Modified Progressive Hedging Algorithm
Authors: Malek Martin , Somplak Radovan , Popela Pavel , Kudela Jakub 
Published: April 2019

In this paper we describe a real-world large-scale stochastic integer waste-management decision making problem. The problem consists of choosing the optimal locations and capacities of new incineration plants, that will be used for the disposal of waste. To solve this problem, we implement a modied version of the progressive hedging algorithm. The presented case study with real-world data concerns the situation in the Czech Republic.
Including Containers with Dangerous Goods in the Multi-Port Master Bay Planning Problem
Authors: Kebedow Kiros Gebrearegawi , Oppen Johan 
Published: April 2019

In this paper we extend existing models for Master Bay Planning by handling containers holding dangerous goods, so-called IMO containers. Incompatible IMO containers must be separated from each other on board a vessel according to specic rules. These rules affect both Master Bay Planning and Slot Planning, which are the two planning problems normally handled in container stowage planning. Some research is doneto include IMO containers in Slot Planning, but, to the best of our knowledge, this is the rst time handling of IMO containers is included in Master Bay Planning. We present results from computational tests showing that our model can be solved to optimality, or near optimality, in reasonable time for realistically sized instances.
PENGANTAR
Authors: Redaksi Pengantar 
Published: April 2019

Assalamualaikum wr. wb.Jurnal Sosiologi Reflektif Volume 13 Nomor 1, Oktober 2018 ini mengkaji permasalahan sosial yang kompleks dalam perspektif sosiologis. Kajian ditulis dalam edisi ini mencakup: gender dan post feminisme, radikalisme dan terorisme, Islam Nusantara, Konflik dan Kajian Budaya di Era Milenial. M. Ali Sofyan menulis Islam dan Posfeminisme: Wajah Posfeminisme dalam Komodifikasi Agama di Media. Menurut penulis, perempuan dalam perspektif posfeminsime dilihat sebagai subjek merdeka. Freedom, gender equality dan representasi yang majemuk menjadi pijakan awal bagi perempuan posfeminisme. Soft Power yang dimiliki social media mengkontekstualisasikan agama (Islam) dalam sebuah metode baru. Agama (Islam) melakukan penyebaran paham termasuk (ke-perempuan-an) dengan metode baru, sehingga konsumsi agama bisa dinikmati setiap detik. Hasil penelitian menunjukan bahwa perspektif tersebut akhirnya dapat menjadikan muslimah berpartisipasi untuk mengatakan “saya cantik untuk saya sendiri”. Meskipun beberapa melihat bahwa mengkapitalisasikan agama merupakan kurang tepat, dalam hal ini komodifikasi agama ternyata dapat mendukung kebebasan perempuan.
KOMUNIKASI POLITIK DI ERA DIGITAL
Authors: Hasfi Nurul 
Published: April 2019

In the last two decades Internet has influenced aspects of human life including democracy. In Indonesian context, since the arrival of Internet in the last 1990s, it was creating new phenomenon known as online political communication. It dramatically have been changing the practice of traditional political communication mediated by convensional media. This article try to provide discussion theoretically and practically relating to the issue. Theoreticaly it explores of how internet has modified classical political communication theory; how new character of Internet has potential effect for producing better quality and quantity of political communication as well as how it has arised problematic issues on the process. Furthermore, this discussion briefly conclude that political communication in the future might never separate from this new medium. It may become most intriguing 'live laboratory' for researcher of the potential roles of the Internet in the political communication process.
A surgeon, a doctor and a baby – combining parenthood with a medical career
Authors: Herath Steven C. , Herath Esther 
Published: April 2019

AbstractDouble-physician couples being parents have been shown to face greater difficulties in combining their private and professional lives when compared to other couples. In the present study, we aimed to analyze how double-physician couples manage to arrange their roles in their private and professional lives and how compatible their individual idea of being a mother or a father is with their career as a physician. Fifteen couples being parents and consisting of either two surgeons or a surgeon and a nonsurgeon were asked to participate in a survey to determine the average maternity or paternity leave, the reduction of hours worked per week after the birth of a child, and the need for professional childcare and additional support in childcare from relatives or babysitters per week. Furthermore, the couples were asked to mark on a six-item Likert scale how compatible their professional life is with their idea of being parents. The average maternity or paternity leave was 13 ± 2 months per child and the mean reduction of hours worked per week was 30 ± 12%. The couples made use of professional childcare for 41 ± 6 h/week on average and needed additional support in childcare from relatives or babysitters for 5 ± 3 h/week. On the Likert scale from “completely incompatible (0)” to “perfectly compatible (5)”, the mean compatibility of professional and private lives was rated 2.5 ± 1.1. Becoming parents significantly influences the professional and private lives of double-physician couples. The relatively low compatibility of double-physician couples’ private and professional lives might lead to relevant work-home conflicts. Such conflicts have been proven to be associated with surgeons not recommending surgery as a career. Therefore, efforts should be made to improve the compatibility of parenthood and a medical career.
Alignment of Vertical and Inclined Jet Grout Columns for Waterproofing
Authors: Cheng Shih-Hao , Liao Hung-Jiun , Yamazaki Junichi , Wong Ricky K. N. , Iwakubo Takeshi 
Published: April 2019

Abstract
Good overlapping among jet grout columns is crucial for the success of waterproofing in the ground. Drilling alignment, column spacing, and diameter of jet grout columns are the controlling factors of good column overlapping. This study evaluated the drilling alignment of vertical and inclined jet grout columns using field-measured alignment data and statistical analysis. A three-dimensional (3-D) image of a jet-grouted mass was established by combining the measurement results of drilling alignment and jet grout column diameter from the trial test. The 3-D image was used to examine the overlapping of the jet grout columns and identify possible locations of windows (non-grouted zones) in the jet-grouted mass. Vertically drilled jet grout holes maintained excellent alignment, with an average estimated inclination angle of 0.43° and standard deviations of 0.11°. However, to avoid underground obstacles, inclined drilling is often required. An inclined drill jet grout hole can easily deviate from its designed drilling alignment because of gravity and result in poor overlapping and potential windows. The average estimated inclination angle and standard deviation of inclined drilling were approximately three times those of vertical drilling.
Analysis of Energy-Efficient Clustering Algorithms for Wireless Sensor Network (WSN)
Authors: Ranganathan Arun , Rangasamy Balamurugan 
Published: April 2019

Abstract
A Wireless Sensor Network (WSN) consists of a huge number of tiny, lesser-cost devices with higher sensing ranges, processing and transmitting abilities. Because the sensor nodes have restricted battery power, energy efficiency is a significant design problem. Clustering is a successful algorithm used to decrease energy usage and increase the lifetime of WSN. Clustering algorithms group similar nodes in independent clusters. Every cluster has at least one Cluster Head (CH). Nodes send packet information to particular CHs. CHs send information to the Base Station. The characteristics of the energy heterogeneity of WSNs must be measured when developing clustering protocols. The major objective of this article is to study a modern survey on several clustering protocols or algorithms reported in the literature on WSNs. The review article also presents a detailed survey of several clustering algorithms for solving energy efficiency problems in WSNs and also presents the issues and advantages of various clustering algorithms in WSNs. The traditional clustering algorithms are simulated broadly, and the results are compared with the existing algorithms to demonstrate their results in terms of network life, energy usage, and Packet Delivery Ratio.
Are soluble ST2 levels influenced by vitamin D and/or the seasons?
Authors: Francic Vito , Keppel Martin , Schwetz Verena , Trummer Christian , Pandis Marlene , Borzan Valentin , Grübler Martin R , Verheyen Nicolas D , Kleber Marcus E , Delgado Graciela , Moissl Angela P , Dieplinger Benjamin , März Winfried , Tomaschitz Andreas , Pilz Stefan , Obermayer-Pietsch Barbara 
Published: April 2019

ObjectiveCardiovascular disease manifestation and several associated surrogate markers, such as vitamin D, have shown substantial seasonal variation. A promising cardiovascular biomarker, soluble ST2 (sST2), has not been investigated in this regard – we therefore determined if systemic levels of sST2 are affected by seasonality and/or vitamin D in order to investigate their clinical interrelation and usability.DesignsST2 levels were measured in two cohorts involving hypertensive patients at cardiovascular risk, the Styrian Vitamin D Hypertension Trial (study A; RCT design, 8 weeks 2800 IU cholecalciferol daily) and the Ludwigshafen Risk and Cardiovascular Health Study (LURIC; study B; cross-sectional design).MethodsThe effects of a vitamin D intervention on sST2 levels were determined in study A using ANCOVA, while seasonality of sST2 levels was determined in study B using ANOVA.ResultsThe concentrations of sST2 remained unchanged by a vitamin D intervention in study A, with a mean treatment effect (95% confidence interval) of 0.1 (−0.6 to 0.8) ng/mL;P = 0.761), despite a rise in 25(OH)D (11.3 (9.2–13.5) ng/mL;P < 0.001) compared to placebo. In study B, seasonal variations were present in 25(OH)D levels in men and women with or without heart failure (P < 0.001 for all subgroups), while sST2 levels remained unaffected by the seasons in all subgroups.ConclusionsOur study provides the first evidence that systemic sST2 levels are not interrelated with vitamin D levels or influenced by the seasons in subjects at cardiovascular risk.
Prognostic significance of TERT promoter and BRAF mutations in TIR-4 and TIR-5 thyroid cytology
Authors: Censi Simona , Barollo Susi , Grespan Elisabetta , Watutantrige-Fernando Sara , Manso Jacopo , Iacobone Maurizio , Casal Ide Eric , Galuppini Francesca , Fassina Ambrogio , Bertazza Loris , Vianello Federica , Pennelli Gianmaria , Mian Caterina 
Published: April 2019

ObjectiveFollicular-derived thyroid cancers generally have a good prognosis, but in a minority of cases, they have an aggressive behavior and develop distant metastases, with an increase in the associated mortality. None of the prognostic markers currently available prior to surgery can identify such cases.MethodsTERTpromoter andBRAFgene mutations were examined in a series of 436 consecutive TIR-4 and TIR-5 nodes referred for surgery. Follow-up (median: 59 months, range: 7–293 months) was available for 384/423 patients with malignant nodes.ResultsTERTpromoter andBRAFmutations were detected in 20/436 (4.6%) and 257/434 thyroid nodules (59.2%), respectively. At the end of the follow-up, 318/384 patients (82.8%) had an excellent outcome, 48/384 (12.5%) had indeterminate response or biochemical persistence, 18/384 (4.7%) had a structural persistence or died from thyroid cancer.TERTpromoter mutations correlated with older age (P < 0.0001), larger tumor size (P = 0.0002), oxyntic and aggressive PTC variants (P = 0.01), higher tumor stages (P < 0.0001), distant metastases (<0.0001) and disease outcome (P < 0.0001). At multivariate analysis,TERTpromoter mutation was not an independent predictor of disease outcome.TERTpromoter mutation- (OR: 40.58; 95% CI: 3.06–539.04), and N1b lymph node metastases (OR: 40.16, 95% CI: 3.48–463.04) were independent predictors of distant metastases.BRAFmutation did not predict the outcome, and it correlated with a lower incidence of distant metastases (P = 0.0201).ConclusionsTERTpromoter mutation proved an independent predictor of distant metastases, giving clinicians the chance to identify many of the patients who warranted more aggressive initial treatment and closer follow-up.
Lietuvos ir Švedijos mokinių požiūris į vaiko teises mokymosi procese
Authors: Jonynienė Živilė , Teresevičienė Margarita 
Published: April 2019

Straipsnyje pristatomi 1998-1999 metais atliktos Lietuvos ir Švedijos mokinių apklausos, kuria buvo siekiama išsiaiškinti mokinių požiūrį į vaiko teisių mokykloje realijas, duomenys. Plačiau aptariami mokytojų ir mokinių lygiateisiškumo, mokinių emocinio ir fizinio saugumo mokykloje klausimai. Nustatyta, kad mokiniams labiausiai trūksta pagarbos jų nuomonei, galimybės būti su mylinčiais ir jais besirūpinančiais žmonėmis, jausmų saugumo.Švedijos moksleivių nuomone, problemiškiausias klausimas mokymosi procese yra jų teisė daryti įtaką sprendimams. Jie pageidauja užimti aktyvią poziciją - nori turėti sprendimo teisę, dalyvauti planuojant ugdymo turinį. Lietuvos mokiniams labiau rūpi tokios mokymosi sąlygos, kai užtikrinama pagarba jų nuomonei, fizinis ir emocinis saugumas, parama. Abiejų šalių mokiniams ypač svarbu, kad mokykloje būtų laikomasi žmogaus teisių ir jos gerbiamos.
Acute Iron Dextran Injection Increases Liver Weight and Reduces Glycerol Kinase Expression in Liver
Authors: Panigoro Ramdan , Ahmad Fadhal M. , Gamayani Uni , Anggraeni Neni , Widyastuti Rini , Ghozali Mohammad , Syamsunarno Mas Rizky A.A 
Published: April 2019

Iron is essential and needed in a very small amount. When iron exceeds normal need, metabolic alteration occurs, causing hepatosteatosis. The mechanism of iron inducing hepatosteatosis remains unclear. Glycerol kinase, the enzyme responsible in triglyceride synthesis initiation, is assumed to have a role in the pathomechanism of hepatosteatosis. This study aimed to investigate the gene expression of glycerol kinase in an acute iron overload condition. This study was conducted in Animal Laboratory Faculty of Medicine and Central Laboratory Universitas Padjadjaran from May to June 2017. Three groups of mice were divided by the dose of iron dextran injection (0, 0.1, 0.3 mg/day/mice). After 19 days, mice were terminated, liver weight was measured and glycerol kinase gene expression in the liver was determined by semi-qualitative PCR. Quantification of PCR result was calculated by ImageJ software. There was a significant change in liver weight of the mice in a dose-dependent manner of iron injection. The expression of glycerol kinase tended to decrease, but statistically insignificant. Acute iron dextran injection increases liver weight and tends to reduce glycerol kinase gene expression in mice liver.Keywords: Glycerol kinase, hepatosteatosis, iron overload Efek Zat Besi Dosis Tinggi Akut dalam Meningkatkan Berat Organ dan Menurunkan Ekspresi Gliserol Kinase HeparAbstrakZat besi merupakan nutrien esensial dan diperlukan dalam jumlah yang sangat kecil. Ketika kadar zat besi melebihi kadar normal dalam tubuh, terjadi perubahan metabolisme yang menyebabkan hepatosteatosis. Mekanisme zat besi dalam menyebabkan hepatosteatosis masih belum diketahui secara pasti. Gliserol kinase, enzim yang menginisiasi sintesis trigliserida, diduga berperan dalam patomekanisme hepatosteatosis. Penelitian ini bertujuan untuk meneliti ekspresi gen gliserol kinase pada hepar pada kondisi tinggi zat besi akut. Penelitian ini dilakukan di Laboratorium Hewan Fakultas Kedokteran dan Laboratorium Sentral Universitas Padjadjaran dari bulan Mei sampai dengan Juni 2017. Tiga kelompok mencit dibagi berdasarkan dosis injeksi iron dextran intraperitoneal (0, 0,1, 0,3 mg/hari/ekor). Setelah 19 hari, mencit diterminasi, berat hepar ditimbang dan ekspresi gen gliserol kinase diukur dengan metode semi-kualitatif PCR. Kuantifikasi hasil PCR dilakukan dengan menggunakan aplikasi ImageJ. Terdapat peningkatan berat hepar secara signifikan yang sejalan dengan dosis ijeksi zat besi. Ekspresi gen gliserol kinase cenderung menurun, meskipun secara statistik tidak signifikan. Keadaan tinggi kadar zat besi yang akut meningkatkan berat hepar dan cenderung menurunkan ekspresi gen gliserol kinase pada hepar mencit.Kata kunci: Gliserol kinase, hepatosteatosis, zat besi berlebih
Effect of Vitamin D deficiency in lower extremity and pulmonary venous thromboembolism
Authors: Dehghani Khatereh , Nowrouzi Aygin , Hossein Pourdavood Amir , Rahmanian Zhila 
Published: April 2019

Introduction: Vitamin D deficiency increases inflammation and dysfunction of pancreas betacells, resulting in atherosclerotic disorders, cerebrovascular disorder, and CVDs.
Methods: In the present cross-sectional study, vitamin D was evaluated in the plasma of 42 patients with lower extremity DVT or PE, as well as 42 healthy controls. Using the chemiluminescence assay, the plasma vitamin D levels were determined. After collection, the blood samples were examined within 60 minutes. Vitamin D levels were classified as sufficient, insufficient, and deficient (> 30 ng/mL, 20- 29 ng/mL, and < 20 ng/mL, respectively).
Results: The prevalence of deficiency in vitamin D was higher in the cases than the controls. The two groups were significantly different regarding vitamin D levels (p = 0.024). Based on the vitamin D classification, deficiency was reported in 30 (71.4%) patients and 18 (42.9%) controls.
Conclusion: Our findings indicated that VTE patients had lower concentration of vitamin D, and the correlation between VTE and vitamin D deficiency was confirmed.