bluuebunny/crossref_metadata_2025_split huggingface dataset:
Immersion‐enhanced fluid redistribution can prevent intradialytic hypotension: A prospective, randomized, crossover clinical trial
Authors: Doenyas‐Barak Keren , Garra Nedal , Beberashvili Ilia , Efrati Shai 
Published: February 2018

AbstractIntroduction: Intradialytic hypotension (IDH) is an important cause of morbidity and mortality among hemodialysis patients. We used an immersion model to evaluate the role of reduced effective circulating volume, and to examine whether facilitated refilling can prevent IDH.Methods: Ten male hemodialysis patients who had frequent episodes of IDH were randomized to a mid‐week “wet” or “dry” hemodialysis session, and subsequently underwent the other session in a crossover manner. The wet sessions were performed while immersed up to the neck in a 34 to 35°C bath, and the dry session was standard hemodialysis. Ultrafiltration goals were determined as the mean ultrafiltration during the 10 sessions preceding the first study session ± 10%.Findings: Mean ultrafiltration was similar for the wet and dry sessions (2.99 ± 0.64 kg vs. 2.96 ± 0.74 kg). Symptomatic hypotension did not develop in any of the patients during the wet session, compared to 4 (40%) during the dry session. Systolic blood pressure adjusted to ultrafiltration was stable during the wet session, 0.22 mmHg/15 min (95% CI −0.27 to 0.70), P = 0.38, and significantly decreased during the dry session, −0.68 mmHg/15 min (95%CI −1.24 to −0.11), P = 0.02. Diastolic blood pressure did not change during the sessions. Mean atrial natriuretic peptide significantly increased in the wet session, by 31.36 pgr/mL (95%CI 8.73–53.99), P = 0.007, and slightly and insignificantly decreased in the dry session, by 21.66 pgr/mL (95% CI −52.59 to 9.25), P = 0.167. Aldosterone blood levels did not change.Discussion: Reduced effective circulating volume is a major cause for IDH, which can be prevented using head‐out water immersion facilitated redistribution.
Clinical nursing and midwifery research in Latin American and Caribbean countries: A scoping review
Authors: Iribarren Sarah , Stonbraker Samantha , Larsen Brandon , Santos Islane , Faria Renata , Góes Fernanda S. N. , Binfa Lorena , Larson Elaine 
Published: February 2018

AbstractAimTo identify and describe published, nursing‐led and midwifery‐led, clinical research that has been conducted in Latin America and the Caribbean.BackgroundPeer‐reviewed published research may correspond to and elucidate country's realities, priorities, and needs.DesignA 6‐stage scoping review methodology was used to search scientific databases using an applied search strategy.Data SourcesFive databases were searched for articles published in English, Spanish, or Portuguese conducted in a Latin American or Caribbean country between January 1, 2006 and June 14, 2016.Review MethodsArticles were independently considered for inclusion by 2 researchers, data extracted, and study characteristics described.ResultsOf 6922 articles identified, 404 were included. The majority were conducted in Brazil (90.6%) followed by Chile (2.5%). Most were nurse‐led (95.8%) and were implemented in hospitals (48.6%). Studies frequently explored patient knowledge or characterized patient populations (61.3%) and commonly assessed chronic disease (19.3%) or maternity/child health outcomes (15.9%).ConclusionFindings revealed a large number of publications but an uneven geographical distribution of nurse‐led clinical research and an evident gap of midwifery‐related research in Latin America and the Caribbean. Results may be used to build research agendas to promote nursing and midwifery research capacity and further establish evidence‐based practice.
Human blood MAIT cell subsets defined using MR1 tetramers
Authors: Gherardin Nicholas A , Souter Michael NT , Koay Hui‐Fern , Mangas Kirstie M , Seemann Torsten , Stinear Timothy P , Eckle Sidonia BG , Berzins Stuart P , d'Udekem Yves , Konstantinov Igor E , Fairlie David P , Ritchie David S , Neeson Paul J , Pellicci Daniel G , Uldrich Adam P , McCluskey James , Godfrey Dale I 
Published: February 2018

AbstractMucosal‐associated invariant T (MAIT) cells represent up to 10% of circulating human T cells. They are usually defined using combinations of non‐lineage‐specific (surrogate) markers such as anti‐TRAV1‐2, CD161, IL‐18Rα and CD26. The development of MR1‐Ag tetramers now permits the specific identification of MAIT cells based on T‐cell receptor specificity. Here, we compare these approaches for identifying MAIT cells and show that surrogate markers are not always accurate in identifying these cells, particularly the CD4+ fraction. Moreover, while all MAIT cell subsets produced comparable levels of IFNγ, TNF and IL‐17A, the CD4+ population produced more IL‐2 than the other subsets. In a human ontogeny study, we show that the frequencies of most MR1 tetramer+ MAIT cells, with the exception of CD4+ MAIT cells, increased from birth to about 25 years of age and declined thereafter. We also demonstrate a positive association between the frequency of MAIT cells and other unconventional T cells including Natural Killer T (NKT) cells and Vδ2+ γδ T cells. Accordingly, this study demonstrates that MAIT cells are phenotypically and functionally diverse, that surrogate markers may not reliably identify all of these cells, and that their numbers are regulated in an age‐dependent manner and correlate with NKT and Vδ2+ γδ T cells.
Developmental endothelial locus‐1 (Del‐1) antagonizes Interleukin‐17‐mediated allergic asthma
Authors: Yan Shu , Chen Li , Zhao Qi , Liu Ya‐Nan , Hou Rui , Yu Jing , Zhang Hong 
Published: February 2018

AbstractInterleukin (IL)‐17 is a major contributor to the pathogenesis of allergic asthma. Developmental endothelial locus‐1 (Del‐1) is an endothelial cell‐secreted protein known to inhibit IL‐17 expression. However, little is known about the association between Del‐1 and IL‐17 in the pathogenesis of allergic asthma. Using bronchoalveolar lavage fluid (BALF) and peripheral blood samples collected from allergic asthmatic patients and controls, we explored the role of Del‐1 in relation to IL‐17 in allergic asthma. We found that the negative correlation between Del‐1 and IL‐17 was significant in BALF of allergic asthmatics. Del‐1 treatment inhibited the expression of IL‐17, the differentiation of IL‐17‐secreting leukocytes and associated cytokines. Contrarily, IL‐17 levels were increased after treatment with anti‐Del‐1 mAb. Consistent with this, Del‐1 treatment led to downregulation of IL‐5, CCL5 and IL‐4, thus reducing secretion of eosinophil cationic protein. Furthermore, Del‐1 significantly downregulated the expression of ICAM‐1 and may have the potential to reduce leukocyte transendothelial migration. Our data demonstrate that Del‐1 can negatively regulate IL‐17 and its proinflammatory function, thereby limiting airway inflammation in allergic asthmatics, and suggest Del‐1 as a potential candidate for prevention and treatment of allergic asthma.
The Use of Prior Information in Very Robust Regression for Fraud Detection
Authors: Riani Marco , Corbellini Aldo , Atkinson Anthony C. 
Published: February 2018

SummaryMisinvoicing is a major tool in fraud including money laundering. We develop a method of detecting the patterns of outliers that indicate systematic mis‐pricing. As the data only become available year by year, we develop a combination of very robust regression and the use of ‘cleaned’ prior information from earlier years, which leads to early and sharp indication of potentially fraudulent activity that can be passed to legal agencies to institute prosecution. As an example, we use yearly imports of a specific seafood into the European Union. This is only one of over one million annual data sets, each of which can currently potentially contain 336 observations. We provide a solution to the resulting big data problem, which requires analysis with the minimum of human intervention.
Burnout in ER nurses: Review of the literature and interview themes
Authors: Abellanoza Adrian , Provenzano‐Hass Nicolette , Gatchel Robert J. 
Published: February 2018

Burnout is especially disruptive among emergency room (ER) nurses. This report covers the influencing factors and outcomes related to burnout in ER nursing populations, with the goal of providing helpful information to a professional audience. The present article includes a literature review on burnout as it occurs in the ER. Interviews from a small sample of ER nurses (n = 5) are analyzed through a combination of deductive thematic analysis and computerized text analysis. Research from various related fields have been pooled together and briefly described. Experiences, comments, and recommendations concerning burnout collected from interviews seem to align with findings from empirical research, and recommendations given by interview nurses closely resemble the recommendations given by researchers. Sentiment analysis revealed a pattern of positive word use when the nurses discussed resources, and a pattern of negative word use when workload was discussed. A better understanding of burnout, both anecdotal and empirical, is valuable information for any professional who works in the ER. Many options exist for reducing or mitigating burnout, including interventions at the individual, team, and organizational levels. More involvement of ER nurses in burnout reduction strategies should be made a priority.
Effect of optical basicity on the stability of yttria‐stabilized zirconia in contact with molten oxy‐fluoride flux
Authors: Guo Jicheng , Villalon Thomas , Pal Uday , Basu Soumendra 
Published: February 2018

AbstractSolid oxide membrane (SOM) electrolysis process can produce high‐purity silicon from SiO2 dissolved in molten oxy‐fluoride flux at elevated temperatures. Yttria‐stabilized zirconia (YSZ), the preferred material for the oxygen‐conducting membrane for this application, is found to degrade over time upon exposure to the silica‐containing molten oxy‐fluoride flux. This YSZ degradation is caused by the acidity of the dissolved silica, especially when the optical basicity of the molten flux is lower than that of the yttria present in the YSZ membrane. To counteract this mismatch, the addition of CaO, a basic oxide, to the flux can adjust the optical basicity of the flux and successfully mitigate the YSZ membrane degradation. The detailed correlation between the rate of YSZ membrane degradation and the optical basicity of the flux is investigated by systematically testing a series of flux compositions. It is found that as the oxide optical basicity in the flux approaches that of the yttria in the YSZ, the degradation of the YSZ membrane is mitigated and essentially vanishes when the flux acidity with respected to the yttria is neutralized. This approach provides a guideline for eliminating membrane degradation during the production of silicon using the SOM electrolysis process.
Effect of thermal history on high‐valence chromium ion dissolution in merwinite (3CaO·MgO·2SiO2)
Authors: Suzuki Masanori , Umesaki Norimasa , Okajima Toshihiro , Tanaka Toshihiro 
Published: February 2018

AbstractSolubility and local structure of transmission elements in calcium silicate compounds has not been well understood. We investigate the local structure of chromium ions dissolved in merwinite (3CaO·MgO·2SiO2) of a monoclinic crystal structure. The acceptance of doping elements into merwinite has not been reported before. We found that chromium ions are soluble in merwinite in air and that chemical valence of the dissolved Cr ions varies with annealing temperature. The absorption edge in the x‐ray absorption near edge structure (XANES) of Cr‐doped merwinite indicated that octahedrally coordinated Cr3+ions were mainly formed when annealed at 1673 K in air. A pre‐edge peak was also detected, indicating the existence of tetrahedrally coordinated high‐valence Cr ions. Conversely, through annealing of merwinite at 1123 K in air, tetrahedrally coordinated Cr6+ions were found to be the main form of chromium. XANES spectra simulated by first‐principle calculations were used to explain the structural features in the observed spectra. We propose the coexistence of Cr3+ions in octahedral Mg2+sites and high‐valence Cr ions in tetrahedral Si4+sites. In addition, a change in the chromium ion oxidation state in tetrahedral coordination sites was suggested by XANES spectroscopy of Cr‐doped merwinite synthesized at 1673 K and reannealed at 1123 K.
A RAndomized Trial to compare the acute reconnection after pulmonary vein ISolation with Laser‐BalloON versus radiofrequency Ablation: RATISBONA trial
Authors: Ücer Ekrem , Janeczko Yvette , Seegers Joachim , Fredersdorf Sabine , Friemel Selina , Poschenrieder Florian , Maier Lars Siegfried , Jungbauer Carsten Gerald 
Published: February 2018

AbstractIntroductionDormant conduction and acute reconnection in the pulmonary veins (PV) during a PV isolation can be detected by performing an adenosine provocation test (APT). Visually guided laser balloon ablation (VGLB) creates deep transmural lesions, thus causing less acute reconnection. This study compared the acute PV reconnection rate after isolation with VGLB or with RF using an APT.Methods and resultsPatients with paroxysmal AF were randomized to PVI with the VGLB or RF ablation. Each PV underwent an APT at least 20 minutes after successful isolation with injection of 18 mg adenosine. Primary endpoint was the difference between the two ablation methods regarding acute PV reconnection rate detected with APT. A total of 50 patients were randomized into the study (25 VGLB). The basic characteristics and mean procedure time were not different between the two groups. Note that 96% of the 97 targeted PVs in the VGLB group and 98% of the 96 targeted PVs in the RF group could be isolated (P = 0.41). APT was performed at similar times (after 28 minutes in VGLB‐arm vs. after 31.5 minutes in RF‐arm; P = 0.12). Significantly less PVs were reconnected during APT in the VGLB group than in the RF group (10 PV [10.8%] vs. 29 PV [30.9%]; P = 0.001).ConclusionThe acute PV reconnection rate is significantly less after PVI with VGBL than with RF. The clinical significance of this apparently better procedural efficiency of the VGBL ablation should be assessed with new randomized studies looking at AF recurrence.
The association of nocturnal hypertension and nondipping blood pressure with treatment‐resistant hypertension: The Jackson Heart Study
Authors: Irvin Marguerite R. , Booth John N. , Sims Mario , Bress Adam P. , Abdalla Marwah , Shimbo Daichi , Calhoun David A. , Muntner Paul 
Published: February 2018

Apparent treatment‐resistant hypertension (aTRH), nocturnal hypertension, and nondipping blood pressure (BP) have shared risk factors. The authors studied the association between aTRH and nocturnal hypertension and aTRH and nondipping BP among 524 black Jackson Heart Study participants treated for hypertension. Nocturnal hypertension was defined by mean nighttime systolic BP ≥120 mm Hg or diastolic BP ≥70 mm Hg. Nondipping BP was defined by mean nighttime to daytime systolic BP ratio >0.90. aTRH was defined by mean clinic systolic BP ≥140 mm Hg and/or diastolic BP ≥90 mm Hg with three medication classes or treatment with four or more classes. The risk for developing aTRH associated with nondipping BP and nocturnal hypertension was estimated. After multivariable adjustment, participants with aTRH were more likely to have nocturnal hypertension (prevalence ratio, 1.20; 95% confidence interval, 1.03–1.39) and nondipping (prevalence ratio, 1.25; 95% confidence interval, 1.09–1.43). Over a median 7.3 years of follow‐up, nocturnal hypertension and nondipping BP at baseline were not associated with developing aTRH after adjustment.
Asymmetric sequential search under incomplete information
Authors: Minchuk Yizhaq , Sela Aner 
Published: February 2018

AbstractWe study a multistage sequential search model with n agents who compete for one job. The agents arrive sequentially, each one in a different stage. The agents' abilities, which are private information, are derived from heterogeneous distribution functions. In each stage, the designer chooses an ability threshold. If an agent has a higher ability than the threshold in the stage in which he arrives, he gets the job and the search is over. The agent's ability is not revealed when he wins the job and the designer has only an estimation of this ability according to the threshold placed by him. We analyze the optimal ability thresholds imposed by the designer who wishes to maximize the ability estimation of the agent who gets the job net of the search cost. We also investigate the relation between the optimal ability thresholds as well as the optimal order of agents in all stages according to the agents' distributions of abilities.
The Relevance of Circular Economy Practices to the Sustainable Development Goals
Authors: Schroeder Patrick , Anggraeni Kartika , Weber Uwe 
Published: February 2018

SummaryThis paper identifies the extent to which circular economy (CE) practices are relevant for the implementation of the Sustainable Development Goals (SDGs). The results of a literature review and a matching exercise to determine the relationship between CE practices and SDG targets show that CE practices, potentially, can contribute directly to achieving a significant number of SDG targets. The strongest relationships exist between CE practices and the targets of SDG 6 (Clean Water and Sanitation), SDG 7 (Affordable and Clean Energy), SDG 8 (Decent Work and Economic Growth), SDG 12 (Responsible Consumption and Production), and SDG 15 (Life on Land). The paper also explores synergies that can be created through CE practices among several of the SDG targets. Furthermore, it identifies several potential trade‐offs between targets for decent work, safe working environments, human health and current CE practices relating to recycling of municipal waste, e‐waste and wastewater, and provides suggestions how these can be overcome. The paper concludes that CE practices can be applied as a “toolbox” and specific implementation approaches for achieving a sizeable number of SDG targets. Further empirical research is necessary to determine which specific types of partnerships and means of implementation are required to apply CE practices in the SDG context.
Simultaneous measurement of quantum yield ratio and absorption ratio between acceptor and donor by linearly unmixing excitation–emission spectra
Authors: ZHANG C. , LIN F. , DU M. , QU W. , MAI Z. , QU J. , CHEN T. 
Published: February 2018

SummaryQuantum yield ratio (QA/QD) and absorption ratio (KA/KD) in all excitation wavelengths used between acceptor and donor are indispensable to quantitative fluorescence resonance energy transfer (FRET) measurement based on linearly unmixing excitation–emission spectra (ExEm‐spFRET). We here describe an approach to simultaneously measure QA/QD and KA/KD values by linearly unmixing the excitation–emission spectra of at least two different donor–acceptor tandem constructs with unknown FRET efficiency. To measure the QA/QD and KA/KD values of Venus (V) to Cerulean (C), we used a wide‐field fluorescence microscope to image living HepG2 cells separately expressing each of four different C–V tandem constructs at different emission wavelengths with 435 nm and 470 nm excitation respectively to obtain the corresponding excitation–emission spectrum (SDA). Every SDA was linearly unmixed into the contributions (weights) of three excitation–emission spectra of donor (WD) and acceptor (WA) as well as donor–acceptor sensitisation (WS). Plot of WS/WD versus WA/WD for the four C–V plasmids from at least 40 cells indicated a linear relationship with 1.865 of absolute intercept (QA/QD) and 0.273 of the reciprocal of slope (KA/KD), which was validated by quantitative FRET measurements adopting 1.865 of QA/QD and 0.273 of KA/KD for C32V, C5V, CVC and VCV constructs respectively in living HepG2 cells.
BALANCED VARIABLE ADDITION IN LINEAR MODELS
Authors: De Luca Giuseppe , Magnus Jan R. , Peracchi Franco 
Published: February 2018

AbstractThis paper studies what happens when we move from a short regression to a long regression in a setting where both regressions are subject to misspecification. In this setup, the least‐squares estimator in the long regression may have larger inconsistency than the least‐squares estimator in the short regression. We provide a simple interpretation for the comparison of the inconsistencies and study under which conditions the additional regressors in the long regression represent a “balanced addition” to the short regression.
A fetus coexisting with a complete hydatidiform mole with trisomy 9 of maternal origin
Authors: Kan Anita Sik Yau , Lau Elizabeth Tak Kwong , So Chun Hong , Chan Wan Pang , Wong Wing Cheuk , Lee Kam Cheong , Pertile Mark D. , Tang Mary Hoi Yin 
Published: February 2018

AbstractA complete hydatidiform mole (CHM) coexisting with a viable fetus is a rare finding in pregnancies. Accurate diagnosis often relies on ultrasonographic, histopathological and molecular techniques in the definite diagnosis. To the best of our knowledge, a liveborn fetus coexisting with CHM with trisomy 9 has not been described. The use of molecular genotyping and immunohistochemical laboratory investigations enabled the CHM to be fully characterized. Postzygotic diploidization of a triploid conception arising from dispermy is the proposed mechanism of its formation.
Microsatellite instability‐high endocervical serous carcinoma manifesting as pulmonary thromboembolism: A case report and review of the literature
Authors: Tsuge Shiori , Ueyama Chikara , Watanabe Kazuko , Nakamura Hiromi , Takeda Akihiro 
Published: February 2018

AbstractA 53‐year‐old obese woman was referred because of sudden onset of dyspnea and chronic vaginal bleeding. In addition to severe anemia, multiple pulmonary emboli were identified. Pelvic imaging showed an irregular‐shaped mass in the region of the endocervix extending to the lower uterine segment. After successful anticoagulant therapy, followed by placement of an inferior vena cava filter, transabdominal hysterectomy and bilateral salpingo‐oophorectomy were performed. An immunopathological study resulted in the diagnosis of endocervical serous carcinoma. After the identification of a high level of microsatellite instability (MSI), an immunohistochemical analysis of mismatch repair (MMR) proteins showed the isolated loss of PMS2. Germline testing of MMR genes showed no mutations, indicating that the high MSI had occurred as a result of sporadic isolated loss of the PMS2 gene expression.
Plasma N‐acylethanolamine and endocannabinoid levels in burning mouth syndrome: Potential role in disease pathogenesis
Authors: Barry Alison , O'Halloran Ken D. , McKenna Joseph P. , McCreary Christine , Harhen Brendan , Kerr Daniel M. , Finn David P. , Downer Eric J. 
Published: February 2018

ObjectiveThe objective was to measure endocannabinoid (eCB) ligands and non‐cannabinoid N‐acylethanolamine (NAE) molecules in plasma from individuals with burning mouth syndrome (BMS) and to determine whether plasma eCB/NAE levels correlated with pain, inflammation and depressive symptomatology in this cohort.Study DesignPlasma content of the eCBs, anandamide (AEA) and 2‐arachidonoyl‐glycerol (2‐AG), and the NAE molecules, palmitoylethanolamide (PEA) and oleoylethanolamide (OEA) were assessed in healthy subjects (n = 8) and in a cohort of newly diagnosed BMS patients (n = 9) using liquid chromatography‐tandem mass spectrometry. Plasma eCBs and NAE profiles were correlated with self‐rated oral cavity pain intensities, depressive symptomatology and plasma IL‐8 levels.ResultsPlasma levels of PEA, but not OEA, AEA or 2‐AG, were significantly elevated in patients with BMS, when compared to plasma from healthy individuals. Plasma PEA, OEA and AEA levels correlated with depressive symptomatology.ConclusionsThis is the first evidence to indicate that circulating eCB/NAE levels are altered in BMS.