bluuebunny/crossref_metadata_2025_split huggingface dataset:
Baseline incidence of adverse birth outcomes and infant influenza and pertussis hospitalisations prior to the introduction of influenza and pertussis vaccination in pregnancy: a data linkage study of 78 382 mother–infant pairs, Northern Territory, Australia, 1994–2015
Authors: McHugh L. , Andrews R.M. , Leckning B. , Snelling T. , Binks M.J. 
Published: July 2019

Abstract
We conducted probabilistic data linkage of three population datasets for the Northern Territory (NT), Australia, to describe the incidence of preterm births, stillbirths, low birthweight and small for gestational age (SGA) per 1000 NT births; and influenza and pertussis hospitalisations per 1 00 000 NT births in infants <7 months of age, in a pre-maternal vaccination era. The Perinatal Trends dataset (1994–2014) formed the cohort of 78 382 births. Aboriginal mother–infant pairs (37%) had disproportionately higher average annual rates (AR) for all adverse birth outcomes compared to their non-Aboriginal counterparts; rate ratios: preterm births 2.2 (AR 142.4 vs. 64.7); stillbirths 2.3 (AR 10.8 vs. 4.6); low birthweight 2.9 (AR 54 vs. 19); and SGA 1.7 (AR 187 vs. 111). Hospitalisation (2000–2015) and Immunisation Register datasets (1994–2015), showed that influenza hospitalisations (n = 53) and rates were 42.3 times higher in Aboriginal infants (AR 254 vs. 6); and that pertussis hospitalisations (n = 37) were 7.1 times higher in Aboriginal infants (AR 142.5 vs. 20.2) compared to non-Aboriginal infants. These baseline data are essential to assess the safety and effectiveness of influenza and pertussis vaccinations in pregnant women from the NT. Remote living Aboriginal women and infants stand to benefit the most from these vaccines.
Regulation of bodily parts: understanding bodily parts as a duplex
Authors: Nwabueze Remigius N. 
Published: July 2019

AbstractThe current law in England and Wales adopts a no-property approach to cadavers and separated bodily parts; paradoxically, it affords proprietary protection to tissue users at the expense of tissue sources. Non-proprietary frameworks hardly offer effective legal redress to tissue sources. Potentially, the law could offer tissue sources a mix of proprietary and non-proprietary remedies. Drawing from the work of the famous anthropologist, Marilyn Strathern, I argue that such a flexible and eclectic approach might be facilitated by the concept ofduplex, an analytical tool that promotes divergent thinking and paradoxical conceptions of a given issue. I argue that while the no-property rule reflects a duplex on bodily parts, the duplex is narrow and ought to be conceptualised more broadly to cover the claims of tissue sources.
An evaluation of predictors of dropout from an Emotional Coping Skills programme in a community mental health service
Authors: Raman Shalini , Richardson Thomas 
Published: July 2019

Abstract
Drop-out from mental health services is a significant problem, leading to inefficient use of resources and poorer outcomes for clients. Adapted dialectical behaviour therapy (DBT), often termed Emotional Coping Skills (ECS) programmes, show some of the highest rates of drop-out from therapy recorded in the literature. The present study aimed to add to the evidence base, by evaluating predictors of drop-out from an ECS programme in a UK-based Community Mental Health Team (CMHT). An existing data set of 49 clients, consisting of clients’ responses on a number of questionnaires, was evaluated for predictors of drop-out. Predictors of drop-out included symptom severity, substance use and client demographics. Independent-samples t-tests and chi-square cross tabs analyses revealed no significant differences between drop-outs and completers of therapy on any of the variables. This suggests that contrary to common assumptions and previous findings, clients using substances, who are highly anxious, or who experience a greater degree of emotion dysregulation, are not more likely to drop out from ECS programmes compared with other individuals. The clinical implications of these findings and future research are discussed within the wider context of the evidence base.

Key learning aims

(1)
To be familiar with common predictors of drop-out from psychological therapies, as indicated by the literature.

(2)
To understand the theories underlying factors that impact drop-out and the associated consequences for mental health services.

(3)
To understand the potential impact of staff assumptions of factors that affect drop-out on client retention.

(4)
To have an understanding of initiatives and strategies that may improve client-retention and engagement in services.
Earth's Bow Shock: A New Three‐Dimensional Asymmetric Model With Dipole Tilt Effects
Authors: Lu J. Y. , Zhou Y. , Ma X. , Wang M. , Kabin K. , Yuan H. Z. 
Published: July 2019

AbstractUsing the bow shock crossing events from four spacecraft: IMP 8, Geotail, Magion‐4, and Cluster 1, a new three‐dimensional asymmetric bow shock model is constructed. The model is parameterized by the solar wind dynamic pressure, the interplanetary magnetic field, magnetosonic Mach number, solar windβ, and the Earth's dipole tilt angle. It is shown that the shape and size of bow shock are both affected by the dipole tilt angle. The dipole tilt angle causes asymmetries in the meridional plane: (1) the bow shock subsolar standoff distance and the north‐south asymmetry increase with the dipole tilt angle; (2) as the dipole tilt angle increases, the shock flaring angle in the equatorial plane is slightly reduced, while in the meridional plane the flaring angle obviously decreases in Southern Hemisphere and keeps almost unchanged in the Northern Hemisphere. The flaring angle in the Northern Hemisphere is larger than in the Southern Hemisphere; (3) the effects of negative dipole tilt angle on shock flaring are just the opposite of those for positive tilt, and the effects of dipole tilt angle on the shape of the bow shock are north‐south symmetric. The model results are also validated by comparing with one previous empirical model and with observational crossings, and it is demonstrated that the new model is able to predict the observed crossings more accurately and can better describe the rotational asymmetry and north‐south asymmetry of the Earth's bow shock.
LES of Flow Through and Around a Finite Patch of Thin Plates
Authors: Gong Yiqing , Stoesser Thorsten , Mao Jingqiao , McSherry Richard 
Published: July 2019

AbstractLarge eddy simulations (LESs) are performed for turbulent flow through and around a porous patch of thin vertical plates at a plate Reynolds number of Rep=5,800. The plates are arranged in a staggered pattern, presenting an elliptical planform and mimicking streamwise‐oriented blades of emergent vegetation. The immersed boundary method is employed to explicitly resolve the interaction between flow and plates. Three flow cases, each with a different number of plates within the same planform area, that is, different patch density, are studied. The Reynolds number based on freestream velocity and plate length is the same in all cases. Inspection of the distribution of velocity and vorticity in the horizontal plane reveals that downstream plates are significantly impacted by the wakes from upstream plates. It is therefore proposed that the plates can be divided into two groups based on the local flow characteristics, which are a function of position within the patch: a free group and a wake group. This classification is subsequently used in the quantitative analysis of boundary layer development and drag force at plate scale. The thickness and character of the simulated boundary layers on the plates differ significantly from predictions based on analytical or empirical relationships, which is due to wake effects and the finite length of the plates. The simulations demonstrate the so‐called sheltering effect; that is, the drag forces acting on downstream plates (in the wake group) are significantly lower than those acting on upstream plates, a result of the lower approach flow speed. Although the front‐area‐to‐lateral‐area ratio of the plates is low (1/40), pressure drag is observed to be larger than friction drag for each plate. The ratio of pressure drag to the total drag at patch scale shows only very little dependence on the plate density of the patch.
Separation and Quantification of Ionospheric Convection Sources: 1. A New Technique
Authors: Reistad J. P. , Laundal K. M. , Østgaard N. , Ohma A. , Haaland S. , Oksavik K. , Milan S. E. 
Published: July 2019

AbstractThis paper describes a novel technique that allows separation and quantification of different sources of convection in the high‐latitude ionosphere. To represent the ionospheric convection electric field, we use the Spherical Elementary Convection Systems representation. We demonstrate how this technique can separate and quantify the contributions from different magnetospheric source regions to the overall ionospheric convection pattern. The technique is in particular useful for distinguishing the contributions of high‐latitude reconnection associated with lobe cells from the low‐latitude reconnection associated with Dungey two‐cell circulation. The results from the current paper are utilized in a companion paper (Reistad et al., 2019, https://doi.org/10.1029/2019JA026641) to quantify how the dipole tilt angle influences lobe convection cells. We also describe a relation bridging other representations of the ionospheric convection electric field or potential to the Spherical Elementary Convection Systems description, enabling a similar separation of convection sources from existing models.
WINDII Observations and WACCM‐X Simulations of High‐Latitude Winds Under Different Solar Radio Flux and Geomagnetic Disturbance Conditions
Authors: Liu Shushi , Shepherd Gordon G. , Chen Yongsheng , Shepherd Marianna G. , Bhutia Sangay 
Published: July 2019

AbstractThermospheric zonal winds at altitudes of 140 to 250 km are shown to reverse from eastward to strong westward between 100° and 200° in geographic longitude and 60°S to 70°S latitude in the Southern Hemisphere. The reversal also occurs at the same latitude in the Northern Hemisphere, but from 200° to 340° longitude. The phenomenon has been previously described as a “wind wall.” Observations by the Wind Imaging Interferometer (WINDII) on the National Aeronautics and Space Administration's Upper Atmosphere Research Satellite (UARS) and simulations by the Whole Atmosphere Community Climate Model with thermosphere and ionosphere extension (WACCM‐X) are utilized to explore the characteristics of what has been called a wind wall. In order to study the dependence on solar radio flux and geomagnetic activity, the relationships of the maximum zonal wind and F10.7 (the solar radio flux at 10.7 cm) and ap indices are investigated. The results show that WINDII observations and WACCM‐X simulations agree well in describing this wind signature. Moreover, the appearance of the wind wall is found to have a strong dependence on the solar radio flux and geomagnetic activity. In addition, WINDII winds have a stronger response to geomagnetic activity than WACCM‐X winds.
Climate Change Trends and Impacts on Vegetation Greening Over the Tibetan Plateau
Authors: Zhong Lei , Ma Yaoming , Xue Yongkang , Piao Shilong 
Published: July 2019

AbstractThe Tibetan Plateau (TP) is an ecologically fragile region that is sensitive to climate change. In the context of global climate change, the climate change trends of the TP and the vegetation dynamic response need to be investigated. Based on in situ meteorological data, Satellite Pour l'Observation de la Terre vegetation data, and Moderate Resolution Imaging Spectroradiometer land cover data, a comprehensive analysis was conducted to determine the trends of climate parameters in the TP region at different time scales (long term: 1960–2014; midterm: 1980–2014; short term 1999–2014). A consistent warming trend was observed for different temporal scales, while a warming slowdown was identified during 1999 and 2014. The warming rate was also shown to be much higher in the high‐altitude regions (>4,000 m), especially at midterm and short‐term time scales. A new cloud‐free time series of vegetation index data sets was reconstructed, and the vegetation density showed a general increasing trend along with a warming trend in the TP. The regions showing significant increases accounted for 7.63% of the total Tibetan territory. The major significant greening trend of the TP was mainly caused by climate factors. The reforestation projects may have played a minor role in the vegetation greening in specific regions of the TP. In addition, various vegetation types showed markedly different responses to climate changes. The grassland in semiarid regions, which accounted for 41.9% of the territory of the TP, was identified to be very sensitive to variations in both temperature and precipitation.
Single-cell biomagnifier for optical nanoscopes and nanotweezers
Authors: Li Yuchao , Liu Xiaoshuai , Li Baojun 
Published: July 2019

AbstractOptical microscopes and optical tweezers, which were invented to image and manipulate microscale objects, have revolutionized cellular and molecular biology. However, the optical resolution is hampered by the diffraction limit; thus, optical microscopes and optical tweezers cannot be directly used to image and manipulate nano-objects. The emerging plasmonic/photonic nanoscopes and nanotweezers can achieve nanometer resolution, but the high-index material structures will easily cause mechanical and photothermal damage to biospecimens. Here, we demonstrate subdiffraction-limit imaging and manipulation of nano-objects by a noninvasive device that was constructed by trapping a cell on a fiber tip. The trapped cell, acting as a biomagnifier, could magnify nanostructures with a resolution of 100 nm (λ/5.5) under white-light microscopy. The focus of the biomagnifier formed a nano-optical trap that allowed precise manipulation of an individual nanoparticle with a radius of 50 nm. This biomagnifier provides a high-precision tool for optical imaging, sensing, and assembly of bionanomaterials.
Halophilic microbial community compositional shift after a rare rainfall in the Atacama Desert
Authors: Uritskiy Gherman , Getsin Samantha , Munn Adam , Gomez-Silva Benito , Davila Alfonso , Glass Brian , Taylor James , DiRuggiero Jocelyne 
Published: July 2019

Abstract
Understanding the mechanisms underlying microbial resistance and resilience to perturbations is essential to predict the impact of climate change on Earth’s ecosystems. However, the resilience and adaptation mechanisms of microbial communities to natural perturbations remain relatively unexplored, particularly in extreme environments. The response of an extremophile community inhabiting halite (salt rocks) in the Atacama Desert to a catastrophic rainfall provided the opportunity to characterize and de-convolute the temporal response of a highly specialized community to a major disturbance. With shotgun metagenomic sequencing, we investigated the halite microbiome taxonomic composition and functional potential over a 4-year longitudinal study, uncovering the dynamics of the initial response and of the recovery of the community after a rainfall event. The observed changes can be recapitulated by two general modes of community shifts—a rapid Type 1 shift and a more gradual Type 2 adjustment. In the initial response, the community entered an unstable intermediate state after stochastic niche re-colonization, resulting in broad predicted protein adaptations to increased water availability. In contrast, during recovery, the community returned to its former functional potential by a gradual shift in abundances of the newly acquired taxa. The general characterization and proposed quantitation of these two modes of community response could potentially be applied to other ecosystems, providing a theoretical framework for prediction of taxonomic and functional flux following environmental changes.
Metabolomic signature of exposure and response to citalopram/escitalopram in depressed outpatients
Authors: Bhattacharyya Sudeepa , Ahmed Ahmed T. , Arnold Matthias , Liu Duan , Luo Chunqiao , Zhu Hongjie , Mahmoudiandehkordi Siamak , Neavin Drew , Louie Gregory , Dunlop Boadie W. , Frye Mark A. , Wang Liewei , Weinshilboum Richard M. , Krishnan Ranga R. , Rush A. John , Kaddurah-Daouk Rima 
Published: July 2019

AbstractMetabolomics provides valuable tools for the study of drug effects, unraveling the mechanism of action and variation in response due to treatment. In this study we used electrochemistry-based targeted metabolomics to gain insights into the mechanisms of action of escitalopram/citalopram focusing on a set of 31 metabolites from neurotransmitter-related pathways. Overall, 290 unipolar patients with major depressive disorder were profiled at baseline, after 4 and 8 weeks of drug treatment. The 17-item Hamilton Depression Rating Scale (HRSD17) scores gauged depressive symptom severity. More significant metabolic changes were found after 8 weeks than 4 weeks post baseline.Within the tryptophan pathway, we noted significant reductions in serotonin (5HT) and increases in indoles that are known to be influenced by human gut microbial cometabolism. 5HT, 5-hydroxyindoleacetate (5HIAA), and the ratio of 5HIAA/5HT showed significant correlations to temporal changes in HRSD17scores.In the tyrosine pathway, changes were observed in the end products of the catecholamines, 3-methoxy-4-hydroxyphenylethyleneglycol and vinylmandelic acid. Furthermore, two phenolic acids, 4-hydroxyphenylacetic acid and 4-hydroxybenzoic acid, produced through noncanconical pathways, were increased with drug exposure.In the purine pathway, significant reductions in hypoxanthine and xanthine levels were observed. Examination of metabolite interactions through differential partial correlation networks revealed changes in guanosine–homogentisic acid and methionine–tyrosine interactions associated with HRSD17. Genetic association studies using the ratios of these interacting pairs of metabolites highlighted two genetic loci harboring genes previously linked to depression, neurotransmission, or neurodegeneration. Overall, exposure to escitalopram/citalopram results in shifts in metabolism through noncanonical pathways, which suggest possible roles for the gut microbiome, oxidative stress, and inflammation-related mechanisms.
ATF3 promotes erastin-induced ferroptosis by suppressing system Xc–
Authors: Wang Liyuan , Liu Yichen , Du Tingting , Yang Heng , Lei Lei , Guo Mengqi , Ding Han-Fei , Zhang Junran , Wang Hongbo , Chen Xiaoguang , Yan Chunhong 
Published: July 2019

AbstractThe amino acid antiporter system Xc− is important for the synthesis of glutathione (GSH) that functions to prevent lipid peroxidation and protect cells from nonapoptotic, iron-dependent death (i.e., ferroptosis). While the activity of system Xc− often positively correlates with the expression level of its light chain encoded by SLC7A11, inhibition of system Xc− activity by small molecules (e.g., erastin) causes a decrease in the intracellular GSH level, leading to ferroptotic cell death. How system Xc− is regulated during ferroptosis remains largely unknown. Here we report that activating transcription factor 3 (ATF3), a common stress sensor, can promote ferroptosis induced by erastin. ATF3 suppressed system Xc−, depleted intracellular GSH, and thereby promoted lipid peroxidation induced by erastin. ATF3 achieved this activity through binding to the SLC7A11 promoter and repressing SLC7A11 expression in a p53-independent manner. These findings thus add ATF3 to a short list of proteins that can regulate system Xc− and promote ferroptosis repressed by this antiporter.
Dephosphorylation of HDAC4 by PP2A-Bδ unravels a new role for the HDAC4/MEF2 axis in myoblast fusion
Authors: Veloso Alexandra , Martin Maud , Bruyr Jonathan , O’Grady Tina , Deroanne Christophe , Mottet Denis , Twizere Jean-Claude , Cherrier Thomas , Dequiedt Franck 
Published: July 2019

AbstractMuscle formation is controlled by a number of key myogenic transcriptional regulators that govern stage-specific gene expression programs and act as terminal effectors of intracellular signaling pathways. To date, the role of phosphatases in the signaling cascades instructing muscle development remains poorly understood. Here, we show that a specific PP2A-B55δ holoenzyme is necessary for skeletal myogenesis. The primary role of PP2A-B55δ is to dephosphorylate histone deacetylase 4 (HDAC4) following myocyte differentiation and ensure repression of Myocyte enhancer factor 2D (MEF2D)-dependent gene expression programs during myogenic fusion. As a crucial HDAC4/MEF2D target gene that governs myocyte fusion, we identify ArgBP2, an upstream inhibitor of Abl, which itself is a repressor of CrkII signaling. Consequently, cells lacking PP2A-B55δ show upregulation of ArgBP2 and hyperactivation of CrkII downstream effectors, including Rac1 and FAK, precluding cytoskeletal and membrane rearrangements associated with myoblast fusion. Both in vitro and in zebrafish, loss-of-function of PP2A-B55δ severely impairs fusion of myocytes and formation of multinucleated muscle fibers, without affecting myoblast differentiation. Taken together, our results establish PP2A-B55δ as the first protein phosphatase to be involved in myoblast fusion and suggest that reversible phosphorylation of HDAC4 may coordinate differentiation and fusion events during myogenesis.
Systemically administered peptain-1 inhibits retinal ganglion cell death in animal models: implications for neuroprotection in glaucoma
Authors: Stankowska Dorota L. , Nam Mi-Hyun , Nahomi Rooban B. , Chaphalkar Renuka M. , Nandi Sandip K. , Fudala Rafal , Krishnamoorthy Raghu R. , Nagaraj Ram H. 
Published: July 2019

AbstractAxonal degeneration and death of retinal ganglion cells (RGCs) are the primary causes of vision loss in glaucoma. In this study, we evaluated the efficacy of a peptide (peptain-1) that exhibits robust chaperone and anti-apoptotic activities against RGC loss in two rodent models and in cultured RGCs. In cultures of rat primary RGCs and in rat retinal explants peptain-1 significantly decreased hypoxia-induced RGC loss when compared to a scrambled peptide. Intraperitoneally (i.p.) injected peptain-1 (conjugated to a Cy7 fluorophore) was detected in the retina indicative of its ability to cross the blood-retinal barrier. Peptain-1 treatment inhibited RGC loss in the retina of mice subjected to ischemia/reperfusion (I/R) injury. A reduction in anterograde axonal transport was also ameliorated by peptain-1 treatment in the retina of I/R injured mice. Furthermore, i.p. injections of peptain-1 significantly reduced RGC death and axonal loss and partially restored retinal mitochondrial cytochrome c oxidase subunit 6b2 (COX 6b2) levels in rats subjected to five weeks of elevated intraocular pressure. We conclude that i.p. injected peptain-1 gains access to the retina and protects both RGC somas and axons against the injury caused by I/R and ocular hypertension. Based on these findings, peptain-1 has the potential to be developed as an efficacious neuroprotective agent for the treatment of glaucoma.