bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hops bitter β‐acids have antibacterial effects against sinonasal Staphylococcus aureus but also induce sinonasal cilia and mitochondrial dysfunction
Authors: Kouakou Yobouet Ines , Thompson Joel C. , Tan Li Hui , Miller Zoey A. , Ma Ray Z. , Adappa Nithin D. , Palmer James N. , Cohen Noam A. , Lee Robert J. 
Published: November 2024

AbstractBackgroundRoutine prescription of antibiotics to treat chronic rhinosinusitis (CRS) exacerbations may contribute to the propagation of antibiotic resistance. Hops bitter β‐acids lupulone and colupulone possess potent antibacterial activities and, as T2R1, T2R14, and/or T2R40 agonists, may improve the impaired mucociliary clearance described in CRS patients. We investigated these molecules as alternative treatments to antibiotics in CRS management based on their antibacterial and T2Rs agonists properties.MethodsHuman nasal primary cells (HNECs) and RPMI2650 cells cultures were used as study models. T2Rs expression in cell culture models and human nasal tissue was assessed using immunofluorescence, quantitative PCR, and Western blot. We performed calcium imaging and cilia beat frequency experiments to investigate T2Rs activation in study models in response to lupulone and colupulone stimulations. Finally, we studied hops β‐acids cytotoxicity on cells using CellEvent, crystal violet, lactate dehydrogenase assays, immunofluorescence, and transepithelial electrical resistance assays.ResultsWe confirmed lupulone and colupulone potent antibacterial effect on CRS‐relevant methicillin‐resistant Staphylococcus aureus but found minimal impact on P. aeruginosa. We also report T2R1, T2R14 and T2R40 expression in HNECs and RPMI2650 cell cultures. Lupulone and colupulone induced an increase in cytosolic calcium that appeared dependent on T2Rs signaling. This response was accompanied by mitochondrial membrane depolarization, cellular energy stress, decreased cell proliferation, ciliostasis, and HNECs remodeling after a single exposure to lupulone at micromolar concentrations.ConclusionOur data suggest that hops β‐acids may not be beneficial as treatments in CRS patients and instead contribute to the disease by impairing cell health and further deteriorating the MCC.
ChatGPT for complex text evaluation tasks
Authors: Thelwall Mike 
Published: November 2024

AbstractChatGPT and other large language models (LLMs) have been successful at natural and computer language processing tasks with varying degrees of complexity. This brief communication summarizes the lessons learned from a series of investigations into its use for the complex text analysis task of research quality evaluation. In summary, ChatGPT is very good at understanding and carrying out complex text processing tasks in the sense of producing plausible responses with minimum input from the researcher. Nevertheless, its outputs require systematic testing to assess their value because they can be misleading. In contrast to simple tasks, the outputs from complex tasks are highly varied and better results can be obtained by repeating the prompts multiple times in different sessions and averaging the ChatGPT outputs. Varying ChatGPT's configuration parameters from their defaults does not seem to be useful, except for the length of the output requested.
Progress and Strategies of MOFs in Catalyzing Conversion Processes in Lithium‐Sulfur Batteries
Authors: Wang Yaru , Rao Xingyou , Pan Zhengdao , Zhao Yan , Zheng Yalong , Luo Yichao , Jiang Xinyu , Wu Yutong , Liu Xiang , Wang Zhoulu , Zhang Yi 
Published: November 2024

AbstractLithium‐sulfur (Li−S) batteries have attracted considerable attention due to their advantages, such as high specific capacity, high energy density, environmental friendliness, and low cost. However, the severe capacity fading caused by shuttle effect of polysulfide needs to be addressed before the practical application of Li−S batteries. Crystalline porous materials including MOFs have generated great interest in energy storage fields especially batteries, because the ordered porous frameworks can offer a fast‐ionic transportation. Nevertheless, the intrinsic low conductivity of MOFs limits their rapid development in lithium‐sulfur batteries. This review mainly discusses the latest research progress on MOF main materials in Li−S batteries. The working principle of Li−S batteries and the classical “adsorption‐catalysis‐conversion” strategy are briefly introduced. Specifically, three modification methods (non‐metal atom doping, single‐atom, and dual‐atom doping modifications) applied in MOF‐based materials are analyzed and summarized, along with their respective mechanisms and advantages and disadvantages. Ligand doping is an effective strategy that can regulate the structure and properties of MOFs, thereby enhancing their catalytic activity and adsorption capacity towards polysulfides. Through ligand doping, key parameters such as the pore size, surface charge, and active site density of MOFs can be controlled, thereby influencing the adsorption and conversion of polysulfides on MOFs surfaces. Furthermore, crucial insights for the rational design of advanced MOF‐based materials for lithium‐sulfur batteries and the exploration of the main challenges and future directions for their application were also discussed.
A comparison of isolated limb infusion/perfusion, immune checkpoint inhibitors, and intralesional therapy as first‐line treatment for patients with melanoma in‐transit metastases
Authors: DePalo Danielle K. , Dugan Michelle M. , Naqvi Syeda Mahrukh Hussnain , Ollila David W. , Hieken Tina J. , Block Matthew S. , van Houdt Winan J. , Wouters Michel W. J. M. , Reijers Sophie J. M. , Asher Nethanel , Broman Kristy K. , Duncan Zoey , Anderson Matilda , Gyorki David E. , Snow Hayden , Held Jenny , Farma Jeffrey M. , Vetto John T. , Hui Jane Y. C. , Kolbow Madison , Saw Robyn P. M. , Lo Serigne N. , Long Georgina V. , Thompson John F. , Kim Youngchul , Karapetyan Lilit , Ny Lars , van Akkooi Alexander C. J. , Olofsson Bagge Roger , Zager Jonathan S. 
Published: November 2024

AbstractBackgroundIsolated limb infusion and perfusion (ILI/ILP) has been a mainstay treatment for unresectable melanoma in‐transit metastases (ITM), but increased use of immune checkpoint inhibitors (ICI) and intralesional therapy (talimogene laherparepvec [TVEC]) introduced several different management options. This study compares first‐line ILI/ILP, ICI, and TVEC.MethodsRetrospective review from 12 international institutions included patients treated from 1990 to 2022 with first‐line ILI/ILP, ICI, or TVEC for unresectable melanoma ITM.ResultsA total of 551 patients were treated, with ILI/ILP (n = 356), ICI (n = 125), and TVEC (n = 70) with median follow‐up of 5.5 years. Tumor burden was highest with ILI/ILP and lowest with TVEC (p = .002). Breslow thickness was lowest with TVEC (p = .007). TVEC was mostly used in stage IIIB disease versus IIIC for ILI/ILP and ICI (p = .01). Using ICI as the reference category, TVEC had the highest odds of a complete response (CR) (odds ratio, 1.96; p = .029) and a longer local progression‐free survival (PFS) (hazard ratio [HR], 0.40; p = .003). ILI/ILP had shorter local PFS (HR, 1.72; p = .012), PFS (HR, 1.79; p < .001), distant metastasis‐free survival (DMFS) (HR, 1.75; p = .014), overall survival (HR, 1.82; p = .009), and melanoma‐specific survival (HR, 2.29; p = .004). Stage IIIB disease had longer DMFS (HR, 0.24; p < .001) compared to IIIC/D.ConclusionsTVEC as first‐line therapy for unresectable melanoma ITM was associated with superior CR rates and local PFS. Notably, TVEC was used in patients with a lower Breslow thickness, disease stage, and tumor burden. Therefore, when compared to ILI/ILP and ICI, TVEC should be considered as first‐line therapy for unresectable stage IIIB melanoma ITM with minimal tumor burden and lower Breslow thickness.
Targeting endoplasmic reticulum stress‐induced lymphatic dysfunction for mitigating bisphosphonate‐related osteonecrosis
Authors: Qin Ziyue , Xie Hanyu , Su Pengcheng , Song Zesheng , Xu Rongyao , Guo Songsong , Fu Yu , Zhang Ping , Jiang Hongbing 
Published: November 2024

AbstractBackgroundBisphosphonates (BPs) are the first‐line treatment to stop bone resorption in diseases, including osteoporosis, Paget's disease, multiple myeloma and bone metastases of cancer. However, BPs‐related osteonecrosis of the jaw (BRONJ), characterized by local inflammation and jawbone necrosis, is a severe intractable complication. The cumulative inflammatory burden often accompanies impaired lymphatic drainage, but its specific impact on BRONJ and the underlying mechanisms remain unclear.MethodsThe mouse BRONJ model was established to assess the integrity and drainage function of lymphatic vessels by tissue clearing techniques, injected indocyanine green lymphatic clearance assay, flow cytometry analysis and histopathological staining. RNA sequencing, metabolome analysis, transmission electron microscopy and Western blotting were utilized to analyze the impacts of Zoledronate acid (ZA) on endoplasmic reticulum stress (ERS) and function of lymphatic endothelial cells (LECs). By constructing Lyve1creERT; SIRT6f/f and Lyve1creERT; ATG5f/f mice, we evaluated the role of ERS‐induced LECs apoptosis in the progression of BRONJ. Additionally, we developed a nanoparticle‐loaded ZA and rapamycin (ZDPR) to enhance autophagy and evaluated its potential in mitigating BRONJ.ResultsThe mouse BRONJ model displayed impaired lymphatic drainage, accompanied by significant local inflammation and bone necrosis. The prolonged stimulation of ZA resulted in the extension of ERS and the inhibition of autophagy in LECs, ultimately leading to apoptosis. Mechanistically, ZA activated XBP1s through the NAD+/SIRT6 pathway, initiating ERS‐induced apoptosis in LECs. The conditional knockout mouse models demonstrated that the deletion of SIRT6 or ATG5 significantly worsened lymphatic drainage and inflammatory infiltration in BRONJ. Additionally, the innovative nanoparticle ZDPR alleviated ERS‐apoptosis in LECs and enhanced lymphatic function, facilitating inflammation resolution.ConclusionOur study has elucidated the role of the NAD+/SIRT6/XBP1s pathway in ERS‐induced apoptosis in ZA‐treated LECs, and further confirmed the therapeutic potential of ZDPR in restoring endothelial function and improving lymphatic drainage, thereby effectively mitigating BRONJ.Key points
Bisphosphonate‐induced lymphatic drainage impairment exacerbates bone necrosis.
Zoledronate acid triggers endoplasmic reticulum stress and apoptosis in lymphatic endothelial cells via the NAD+/SIRT6/XBP1s pathway.
Novel nanoparticle‐loaded Zoledronate acid and rapamycin enhances autophagy, restores lymphatic function, and mitigates bisphosphonates‐related osteonecrosis of the jaw progression.
The Prospect of Artificial Intelligence‐Supported Ethics Review
Authors: Nickel Philip J. 
Published: November 2024

ABSTRACTThe burden of research ethics review falls not just on researchers, but also on those who serve on research ethics committees (RECs). With the advent of automated text analysis and generative artificial intelligence (AI), it has recently become possible to teach AI models to support human judgment, for example, by highlighting relevant parts of a text and suggesting actionable precedents and explanations. It is time to consider how such tools might be used to support ethics review and oversight. This essay argues that with a suitable strategy of engagement, AI can be used in a variety of ways that genuinely support RECs to manage their workload and improve the quality of review. It would be wiser to take an active role in the development of AI tools for ethics review, rather than to adopt ad hoc tools after the fact.
Effects of Controlling Assist Robots to Follow Lumbar Load on Muscle Fatigue
Authors: Yoshida Yusuke , Kamezaki Takashi , Kushida Daisuke 
Published: November 2024

ABSTRACTWe developed an assist robot that changes its assist force in real time according to the lumbar load estimated from the load information on the hand measured using a hand sensor device and the posture information. Furthermore, using the developed assist robot, the effect of the load‐following control on muscle fatigue was verified. The load was set at 6 and 1 kgf, and the amount of muscle activity in the lumbar region was measured using a muscle potential sensor during continuous flexion–extension exercises. The central frequency of the power spectrum was calculated as muscle fatigue, and its time trend was obtained. For comparison, similar experiments were also conducted without an assistive robot and with an existing assistive robot. Consequently, when load‐following control was used, muscle fatigue was reduced compared with existing assist robots in which the assist force was excessive in relation to the load. This shows the importance of load‐following control that is necessary to control the assist force according to the load when the assist robot is worn during work in which the load changes in a complex manner.
Flow Resistance Coefficient Under Rigid Vegetation Coverage: An Experimental Study
Authors: Cai Zekang , Wang Jian , Xie Jiabo , Wang Chenfeng 
Published: November 2024

ABSTRACTRigid vegetation is prevalent in the Loess Plateau region. Most simulation studies assume that vegetation grows perpendicularly to the slope surface (BS), overlooking the influence of growth perpendicular to the horizontal plane (BH) on the slope flow resistance coefficient. Therefore, this study explores the effects of rigid vegetation on the slope flow resistance coefficient by conducting indoor simulated scouring experiments under different vegetation coverage (0–15.89%), two growth directions (BS and BH), four slopes (5°, 10°, 15° and 20°), and five flow rates (5, 10, 20, 30 and 40 L·min−1). The results showed that the resistance coefficient increased non‐linearly with vegetation coverage; however, the growth rate slowed with increasing slope at high coverage, showing a decreasing trend. The resistance coefficient under BS conditions was generally higher than that under BH conditions. As the coverage increased (0–15.89%), the resistance coefficient under BS conditions became 1.51–1.99, 1.1–1.26 and 1.52–1.59 times that under BH conditions. The resistance coefficient ratio negatively correlated with the flow rate and water depth and positively with the slope. Furthermore, the relationship between the Reynolds number (Re) and resistance coefficient under BS and BH conditions significantly differed, with a negative correlation under BS conditions and a positive one under BH conditions. The Froude number (Fr) exhibited a strong negative correlation with the resistance coefficient, and the impact became more significant as vegetation coverage increased. Through dimensional analysis and nonlinear fitting, a high‐precision resistance coefficient prediction model (adjR2 = 0.98, NSE = 0.99, RRMSE = 0.04) was developed, which provided theoretical support for engineering designs and enhancing soil and water conservation strategies on the Loess Plateau.
A contemporary simple risk score for prediction of severe acute kidney injury after heart transplantation
Authors: Zhu Shuangshuang , Qiao Weihua , Wang Yixuan , Zhou Ying , Xu Yin , Wang Shijie , Xia Tian , Wang Guohua , Chen Si , Shi Jiawei , Dong Nianguo 
Published: November 2024

AbstractBackgroundThe aim of this study was to develop a simple risk score to estimate severe acute kidney injury (AKI) risk based on a large contemporary heart transplantation (HT) cohort.MethodsFrom 1 January 2015 to 31 December 2021, all consecutive HT recipients in our institute were included and analysed for the occurrence of AKI within the first seven postoperative days. Patients transplanted between 2015 and 2019 comprised the derivation cohort, and those transplanted between 2020 and 2021 formed the validation cohort. The primary endpoint was severe AKI (AKI stages 2–3). The impact of severe AKI on 90 day mortality was also evaluated.ResultsOverall, 430 HT patients were included in the derivation cohort, and 108 were included in the validation cohort. Postoperative AKI occurred in 388 (72%) patients, including 162 (30%) severe AKI. The risk of 90 day mortality significantly increased in patients with severe‐AKI. Seven independent predictors of severe AKI were found in the derivation cohort, including recipients' body mass index, history of diabetes, anaemia, preoperative inotropes, estimated glomerular filtration rate, cardiopulmonary bypass duration and intraoperative red blood cell transfusion. The occurrence of severe AKI increased gradually from the lowest to the highest of the four risk score groups in the derivation and validation cohort. The scoring prediction model showed a highly acceptable discriminating power for severe‐AKI [C statistic: 0.76, 95% confidence interval (CI): 0.71–0.80 for derivation cohort; C statistic: 0.79, 95% CI: 0.71–0.89 for validation cohort].ConclusionsA contemporary simple risk score based on available variables from patients undergoing HT can accurately discriminate the risk of severe AKI.
Empowering Women to Lead Cybersecurity: The Effect of Female Executives on Disclosure Sentiment
Authors: Elnahass Marwa , Ahmed Yousry , Trinh Vu Quang 
Published: November 2024

ABSTRACTThis study investigates the impact of gender diversity (i.e., the presence of female executives on corporate boards) on the sentiment of cybersecurity information disclosure, including its likelihood, magnitude, and tone. We develop a unique dataset providing an extensive view of the development and evolution of cybersecurity‐related disclosure practices among prominent publicly traded US companies over a 19‐year period (2002–2020). We find strong evidence that female executives are more likely to disclose, and they report significantly more cybersecurity‐related information compared to their male counterparts. Additionally, female executives adopt a more conservative, uncertain, and litigious tone in their cybersecurity disclosures than male executives. The results also support the notion of a critical mass of female executives on the board and align with various theories, emphasising the importance of gender diversity in promoting high‐quality cybersecurity disclosure practices within firms. Furthermore, we examine several channels contributing to the heterogeneity of cybersecurity disclosures between female and male executives, and consider the effects of the black swan events (i.e., the financial crisis and the COVID‐19 pandemic).
The Moderating Roles of Economic Complexity in the Entrepreneurship‐Sustainable Environment Nexus for the Gulf Cooperation Council Economies
Authors: Dada James Temitope , Ajide Folorunsho Monsur , Arnaut Marina , Al‐Faryan Mamdouh Abdulaziz Saleh 
Published: November 2024

ABSTRACTThere are conflicting views on the effect of business and entrepreneurial activities on environmental degradation in developing economies. However, none of this study examines whether economic complexity can serve as a policy tool for mitigating the effect of entrepreneurial business activities on a sustainable environment. Economic complexity consists of the structural and economic transformation process from a simple production system to a more complex and innovation‐based one. It predicts the variations in income level and its impact on the choice of goods being produced in an economy. This study examines the moderating effect of economic complexity on the link between entrepreneurship and sustainable environment in Gulf Cooperation Council (GCC) countries from 2006 to 2020. It further examines the validity of the Entrepreneurial Environmental Kuznets Curve (EEKC). The study uses the Driscoll‐Kraay standard error fixed effect, Panels Corrected Standard Errors (PCSE), method of moment quantile regression and Dumitrescu–Hurlin causality that are robust to heteroscedasticity, cross‐sectional dependency and other pitfalls of least square estimating technique. The results validate the inverted U‐shaped EEKC hypothesis across all the quantiles. Economic complexity increases ecological degradation at the lower quantile levels, while it decreases environmental footprint at the upper quantiles. Furthermore, economic complexity moderates the detrimental impact of entrepreneurial activity on the environment at the higher quantiles. A two‐way relationship is established between entrepreneurial activity and the environment, while one one‐way connection from economic complexity to the environment was found. The study recommends that policymakers should encourage innovative rather than necessity entrepreneurs. Entrepreneurs should be encouraged to engage in business activities that are friendly toward preserving the ecological environment, and green innovative activities should be prioritised in their entrepreneurial activities.
Proposal for a new classification of intrauterine adhesions by sites
Authors: Lasmar Ricardo Bassil , Lasmar Bernardo Portugal , Haimovich Sergio , Pacheco Luis Alonso , Moawad Nash S. 
Published: November 2024

AbstractThe authors propose a new classification of intrauterine adhesions (IUAs) to facilitate understanding for both the gynecologist and the patient, documenting the location and characteristics of the adhesions in a single image. This tool significantly improves surgical planning and patient outcomes in the treatment of intrauterine adhesions. In addition, having a simple and consistent method of describing IUAs will facilitate longitudinal studies tracking the outcomes of various surgical techniques, adhesion barriers and the impact of hormonal treatment. The proposed new classification system may represent a significant advancement in the field of gynecology. Its adoption may facilitate and simplify the representation of intrauterine adhesion sites, allowing for better communication between doctors and more effective management of intrauterine adhesions.
Reducing Makespan and Enhancing Resource Usage in Cloud Computing With ESJFP Method: A New Dynamic Approach
Authors: Laha Jasobanta , Pattnaik Sabyasachi , Chaudhury Kumar Surjeet , Palai Gopinath 
Published: November 2024

ABSTRACTA well‐designed web‐based tool or application allows consumers to access on‐demand services on a pay‐per‐use basis via the internet in the cloud computing service paradigm. Cloud computing continues to be a leading technology trend, with a primary focus on optimizing and enhancing end‐user applications. The increasing challenge of meeting the diverse needs of clints for service providers is propelling the development of load scheduling algorithms. Some of the current scheduling algorithms used in cloud computing include First Come First Serve (FCFS), Shortest Job First (SJF) and Round Robin (RR). The response time and makespan—the interval between the start and end times of consecutive tasks on the same machine—are the two most crucial load balancing elements. Response time refers to the duration a server takes to respond to a client's request. Measured in milliseconds, this timer starts when a client sends a request and stops when the server sends its initial response. This study examines many load balancing methods and suggests improvements for cloud computing's Shortest Job First (SJF) methodology. To minimize makespan and maximize resource usage, we provide a solution that is Enhanced Shortest Job First with Priority (ESJFP) load scheduling algorithms. Under the ESJFP method, computers with more processing power are assigned the longest tasks with higher MIPS (million instructions per second) needs, while machines with lesser processing capacity are assigned the shortest jobs with lower MIPS requirements. By giving equal priority to all activities, this technique makes sure that neither high‐MIPS nor low‐MIPS jobs have to wait an extended period of time for resource allocation.