bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effectiveness of biofilm‐based wound care system on wound healing in chronic wounds
Authors: Mori Yukie , Nakagami Gojiro , Kitamura Aya , Minematsu Takeo , Kinoshita Mikio , Suga Hiraku , Kurita Masakazu , Hayashi Chieko , Kawasaki Akiko , Sanada Hiromi 
Published: May 2019

ABSTRACTA biofilm plays a crucial role in delaying wound healing. Sharp debridement, a possible effective method for eliminating biofilms, can only be applied to the wound with visible necrotic tissue; thus, no option has been available for eliminating biofilms that are not accompanied by necrotic tissue. Wound blotting was recently developed to visualize biofilm noninvasively and quickly, and ultrasonic debridement is available for biofilm removal. Therefore, the purpose of this study was to investigate the efficacy of “biofilm‐based wound care system (BWCS),” a combination of wound blotting as a point‐of‐care testing and ultrasonic debridement, for promoting wound healing. Firstly, the cross‐sectional study was conducted to examine the proportion of biofilm removal by ultrasonic debridement in pressure ulcers [Study 1]. Subsequently, the retrospective cohort study was conducted to examine the effectiveness of BWCS for healing of chronic wounds [Study 2]. The proportions of wound healing between wounds treated with BWCS and those with standard care in the home‐visiting clinic were compared by Kaplan–Meier curve, and the Cox proportional hazard modeling was used to assess the effect of BWCS on wound healing. In Study 1, the median of biofilm removal proportion was 38.9% (interquartile range, 12.9–68.0%) for pressure ulcers treated with standard care and 65.2% (41.1–78.8%) for those treated with ultrasonic debridement (p = 0.009). In Study 2, the proportion of wound healing within 90 days was significantly higher in wounds treated with BWCS than in those treated with standard care (p = 0.001). The adjusted hazard ratio of BWCS for wound healing was 4.5 (95% confidence interval, 1.3–15.0; p = 0.015). In conclusion, we demonstrated that our novel approach, BWCS, can be a promising therapeutic strategy for visualizing biofilms that are not accompanied by necrotic tissue and promoting healing in chronic wounds.
Molecular phylogeny of the Cyathocotylidae (Digenea, Diplostomoidea) necessitates systematic changes and reveals a history of host and environment switches
Authors: Achatz Tyler J. , Pulis Eric E. , Junker Kerstin , Binh Tran Thi , Snyder Scott D. , Tkach Vasyl V. 
Published: May 2019

AbstractThe Cyathocotylidae is a globally distributed family of digeneans parasitic as adults in fish, reptiles, birds and mammals in both freshwater and marine environments. Molecular phylogenetic analysis of interrelationships among cyathocotylids is lacking with only a few species included in previous studies. We used sequences of the nuclear 28S rRNA gene to examine phylogenetic affinities of 11 newly sequenced taxa of cyathocotylids and the closely related family Brauninidae collected from fish, reptiles, birds and dolphins from Australia, Southeast Asia, Europe, North America and South America. This is the first study to provide sequence data from adult cyathocotylids parasitic in fish and reptiles. Our analyses demonstrated that the members of the genus Braunina (family Brauninidae) belong to the Cyathocotylidae, placing the Brauninidae into synonymy with the Cyathocotylidae. In addition, our DNA sequences supported the presence of a second species in the currently monotypic Braunina. Our phylogeny revealed that Cyathocotyle spp. from crocodilians belong to a separate genus (Suchocyathocotyle, previously proposed as a subgenus) and subfamily (Suchocyathocotylinae subfam. n.). Morphological study of Gogatea serpentum indicum supported its elevation to species as Gogatea mehri. The phylogeny did not support Holostephanoides within the subfamily Cyathocotylinae; instead, Holostephanoides formed a strongly supported clade with members of the subfamily Szidatiinae (Gogatea and Neogogatea). Therefore, we transfer Holostephanoides into the Szidatiinae. DNA sequence data revealed the potential presence of cryptic species reported under the name Mesostephanus microbursa. Our phylogeny indicated at least two major host switching events in the evolutionary history of the subfamily Szidatiinae which likely resulted in the transition of these parasites from birds to fish and snakes. Likewise, the transition to dolphins by Braunina represents another major host switching event among the Cyathocotylidae. In addition, our phylogeny revealed more than a single transition between freshwater and marine environments demonstrated in our dataset by Braunina and some Mesostephanus.
Experimental Investigation of Convective Heat Transfer of Supercritical Pressure Hydrocarbon Fuel in a Horizontal Section of a Rotating U-Duct
Authors: Lu Zelong , Zhu Yinhai , Guo Yuxuan , Jiang Peixue 
Published: May 2019

Abstract
The experimental and numerical investigations of the heat transfer of supercritical pressure n-decane flowing through a pipe at various rotational speeds, mass flow rates, heat fluxes, and pressures, are presented. This pipe is 2 mm in diameter, 200 mm in length, with a radius of 0.328 m, and is parallel to the rotating axis. The wall temperature was measured at four positions around the periphery of the pipe at each of the five selected cross section along the pipe's length. Maximum convective heat transfer was observed at the outer edge of the horizontal section, while its corresponding minimum was observed at the inner edge. The heat transfers at the two sides of the channel were observed to be similar. The density and pressure differences between the outer and inner edges increased at increasing rotating speeds. However, the temperature difference between the outer and inner edges decreased with increased rotational speed mainly because of the increase of secondary flows in the section. The section's average convective heat transfer coefficient increased with an increase in the rotational speed, and its value at 1000 rpm was approximately twice than that at static conditions. The phenomenon of oscillation was observed near the exit of the horizontal section, and was caused by the flow and considerable property changes near the pseudo critical temperature. A computational fluid dynamics (CFD) model was developed using the real gas thermal properties and was coupled with the heat transferred owing to fuel flow. The predicted fuel and wall temperatures were in good agreement with the experimental data. A new local Nusselt number correlation of the heat transfer of n-decane in a rotating horizontal section was proposed.
The End of a Professional Sport Career: Ensuring a Positive Transition
Authors: Knights Sophie , Sherry Emma , Ruddock-Hudson Mandy , O’Halloran Paul 
Published: May 2019

The purpose of this research was to explore the experience of transition and life after sport in a group of retired professional athletes. A total of 45 retired athletes from three national football leagues took part in semistructured interviews. Two overarching themes emerged from the data analysis: (a) preparing for transition and planning for retirement and (b) supportive environment. For athletes in this study, four main factors were identified as critical to promoting a positive transition. The nature of the transition also directly affected athletes’ experience of retirement from sport and, thus, their experience of flourishing in life after sport. The majority of participants in this study indicated that they lacked support from their sporting club and governing bodies both during their transition and in retirement. Planning for retirement and preparing for the future positively affected their ability to flourish in retirement. Recommendations for sport managers and athlete support services are provided.
Ancient DNA reveals a multistep spread of the first herders into sub-Saharan Africa
Authors: Prendergast Mary E. , Lipson Mark , Sawchuk Elizabeth A. , Olalde Iñigo , Ogola Christine A. , Rohland Nadin , Sirak Kendra A. , Adamski Nicole , Bernardos Rebecca , Broomandkhoshbacht Nasreen , Callan Kimberly , Culleton Brendan J. , Eccles Laurie , Harper Thomas K. , Lawson Ann Marie , Mah Matthew , Oppenheimer Jonas , Stewardson Kristin , Zalzala Fatma , Ambrose Stanley H. , Ayodo George , Gates Henry Louis , Gidna Agness O. , Katongo Maggie , Kwekason Amandus , Mabulla Audax Z. P. , Mudenda George S. , Ndiema Emmanuel K. , Nelson Charles , Robertshaw Peter , Kennett Douglas J. , Manthi Fredrick K. , Reich David 
Published: May 2019

East African genetics and pastoralismThe origin and spread of domestic animals across the globe also affected the underlying genetic composition of human populations. In Africa, however, it has been difficult to identify the impact of interactions among migrating food producers and local hunter-gatherers. Prendergastet al.wanted to discern the timing and movement of husbandry and pastoralism and its effects on foraging communities in Africa. They sequenced 41 ancient eastern African human genomes from individuals that lived approximately 100 to 4000 years ago. Surprisingly, relatively little genetic mixture occurred at the same time as the spread of pastoralism.Science, this issue p.eaaw6275
Estimates of all cause mortality and cause specific mortality associated with proton pump inhibitors among US veterans: cohort study
Authors: Xie Yan , Bowe Benjamin , Yan Yan , Xian Hong , Li Tingting , Al-Aly Ziyad 
Published: May 2019

AbstractObjectiveTo estimate all cause mortality and cause specific mortality among patients taking proton pump inhibitors (PPIs).DesignLongitudinal observational cohort study.SettingUS Department of Veterans Affairs.ParticipantsNew users of PPIs (n=157 625) or H2 blockers (n=56 842).Main outcome measuresAll cause mortality and cause specific mortality associated with taking PPIs (values reported as number of attributable deaths per 1000 patients taking PPIs).ResultsThere were 45.20 excess deaths (95% confidence interval 28.20 to 61.40) per 1000 patients taking PPIs. Circulatory system diseases (number of attributable deaths per 1000 patients taking PPIs 17.47, 95% confidence interval 5.47 to 28.80), neoplasms (12.94, 1.24 to 24.28), infectious and parasitic diseases (4.20, 1.57 to 7.02), and genitourinary system diseases (6.25, 3.22 to 9.24) were associated with taking PPIs. There was a graded relation between cumulative duration of PPI exposure and the risk of all cause mortality and death due to circulatory system diseases, neoplasms, and genitourinary system diseases. Analyses of subcauses of death suggested that taking PPIs was associated with an excess mortality due to cardiovascular disease (15.48, 5.02 to 25.19) and chronic kidney disease (4.19, 1.56 to 6.58). Among patients without documented indication for acid suppression drugs (n=116 377), taking PPIs was associated with an excess mortality due to cardiovascular disease (22.91, 11.89 to 33.57), chronic kidney disease (4.74, 1.53 to 8.05), and upper gastrointestinal cancer (3.12, 0.91 to 5.44). Formal interaction analyses suggested that the risk of death due to these subcauses was not modified by a history of cardiovascular disease, chronic kidney disease, or upper gastrointestinal cancer. Taking PPIs was not associated with an excess burden of transportation related mortality and death due to peptic ulcer disease (as negative outcome controls).ConclusionsTaking PPIs is associated with a small excess of cause specific mortality including death due to cardiovascular disease, chronic kidney disease, and upper gastrointestinal cancer. The burden was also observed in patients without an indication for PPI use. Heightened vigilance in the use of PPI may be warranted.
Coeliac disease: no difference in milk and dairy products consumption in comparison with controls
Authors: Zingone Fabiana , Iovino Paola , Bucci Cristina , Ciacci Carolina 
Published: May 2019

BackgroundNutritional deficiencies are common in patients with coeliac disease and they can cause osteopenia among other associated diseases. Reduced consumption of milk and dairy products may play a major role in determining low bone mass in patients with coeliac disease.AimWe aimed to investigate milk and dairy products consumption in patients with coeliac disease compared with the general population.MethodsWe examined the average consumption of milk and dairy products and the reasons for not consuming them. An online survey was sent by email to patients with coeliac disease on a gluten-free diet and aged 18–75. Matched controls were selected among volunteers who responded to the survey posted on the public access sites. Differences in frequencies and means between the two groups were calculated using the χ2test and t-test, respectively. All tests were two-tailed with a significance level set at p<0.05.Results176 patients with coeliac disease and 528 controls participated in the study. We found that 22.2% of the patients with coeliac disease and 19.9% of controls did not drink fluid milk on a regular basis; lactose-free milk was preferred by 20.4% of the patients with coeliac disease and by 19% of controls (p=0.69). Only a minority of patients with coeliac disease contacted a doctor before having lactose-free milk, despite this being led by the presence of gastrointestinal symptoms. More patients with coeliac disease than the general population reported a breath test before avoiding milk and dairy products.ConclusionsThere is no significant difference between patients with coeliac disease and controls in regular milk consumption. Follow-up visits for patients with coeliac disease could avoid unnecessary dietary restrictions.
Parity and the use of folic acid supplementation during pregnancy
Authors: Sharman Moser Sarah , Rabinovitch Maayan , Rotem Ran , Koren Gideon , Shalev Varda , Chodick Gabriel 
Published: May 2019

ObjectiveFolic acid (FA) supplementation has long been recommended before and during pregnancy to reduce the risk of neural tube defects. Factors influencing adherence to FA supplementation have been extensively evaluated, but little is known on the effect of parity. This study comes to examine the association between parity and maternal use of FA prior to and during pregnancy.MethodsIn this retrospective population-based study, we identified mothers (N=228 555) of all children (N=578 204) born between the years 2000 and 2016 among members of a large health provider in Israel. Data on FA supplementation purchases were obtained from centralised medical databases.ResultsThe median (IQR) total dose of FA purchased 12 months prior to child birth among previously nulliparous women (120 mg, 48–240) was significantly (p<0.001) higher than the dose purchased by women with one (90 mg (39–202)) and two prior births (84 mg (36–182)). The dose was even lower in women for three or more prior births (75 mg (36–165)). Despite the overall increasing secular trend in FA purchases during the study period, the negative relationship with parity remained.ConclusionsAdherence to FA supplementation is negatively associated with parity. Women with increasing parity may be at higher risk for pregnancy complications associated with low FA levels. The results of this study may inform the design of interventions to specifically increase adherence to FA supplementations among multiparous women.
Seeking culturally safe care: a qualitative systematic review of the healthcare experiences of women and girls who have undergone female genital mutilation/cutting
Authors: Evans Catrin , Tweheyo Ritah , McGarry Julie , Eldridge Jeanette , Albert Juliet , Nkoyo Valentine , Higginbottom Gina Marie Awoko 
Published: May 2019

ObjectiveTo explore the experiences of accessing and receiving healthcare related to female genital mutilation/cutting (FGM/C) across the life course from the perspective of women and girls who have undergone FGM/C.DesignA systematic review of qualitative research studies using a thematic synthesis approach.MethodsInclusion criteria were qualitative studies (including grey literature) of any design, from Organisation for Economic Co-operation and Development (OECD) countries, of any date and any language. Sixteen electronic databases were searched from inception to December 2017, supplemented by reference list searching. Papers were screened, selected and quality-appraised by two reviewers using established tools from the Joanna Briggs Institute. NVivo software was used to extract study characteristics and code study findings. An inductive thematic synthesis approach was undertaken to identify descriptive themes and interpret these into higher order analytical constructs. Confidence in the review findings was assessed using Grading of Recommendations, Assessment, Development and Evaluations-Confidence in Evidence from Reviews of Qualitative Research (GRADE-CERQual).ResultsFifty-seven papers (from 55 distinct studies) from 14 different OECD countries were included (50% published within the last 8 years). One-third of studies focused exclusively on maternity care experiences, whereas others covered a range of foci. No studies reported explicitly on girls’ experiences or on experiences of health service-led safeguarding interventions. Only three studies addressed psychological care. The synthesis developed 17 descriptive themes, organised into 5 analytical constructs. These related to communication, access to care, experiences of cultural dissonance/integrity, disempowering care experiences and positive care encounters. The themes illuminate significant challenges to obtaining timely and holistic care (especially for deinfibulation), and highlight different ways in which women may experience care as disrespectful, unsafe and disempowering. Key elements of ‘culturally safe care’ are identified.ConclusionsThis review has highlighted key knowledge gaps, especially around (1) girls’/unmarried women’s experiences and (2) the impact of recent safeguarding interventions. There is an ongoing need for community engagement, service development and staff training.PROSPERO registration numberCRD420150300012015.
Systematic review and meta-analysis of clinical significance of autoantibodies for idiopathic pulmonary fibrosis
Authors: Kamiya Hiroyuki , Panlaqui Ogee Mer 
Published: May 2019

ObjectiveTo clarify clinical significance of the sole presence of autoantibodies for idiopathic pulmonary fibrosis (IPF) without any other symptoms or signs suggestive of autoimmune disease.DesignSystematic review and meta-analysisData sourcesMedline, EMBASE, Science Citation Index Expanded and Google Scholar were searched from 1 January 2002 through 12 February 2019.Eligibility criteria for selecting studiesPrimary studies addressing all-cause mortality and the development of a defined autoimmune disease for IPF with autoantibodies were included for the review.Data extraction and synthesisTwo reviewers extracted relevant data and assessed risk of bias independently. Meta-analysis was conducted using a random-effects model if three or more studies reported the same outcome for a certain autoantibody. The quality of evidence was assessed by the Grades of Recommendation, Assessment, Development and Evaluation system.ResultsOut of 4603 records retrieved nine studies were included in this review. All studies contained some risk of bias. Based on pooled data myeloperoxidase antineutrophil cytoplasmic antibody (MPO-ANCA) was significantly associated with microscopic polyangiitis incidence with risk ratio (RR) of 20.2 (95% CI: 7.22 to 56.4) and antinuclear antibody (ANA) was also significantly associated with the development of connective tissue diseases with RR of 7.11 (p=0.001) (10 cases in 157 patients with ANA) in one study. However, there was no significant association of autoantibodies with all-cause mortality aside from MPO-ANCA and proteinase 3-ANCA in one study each. MPO-ANCA was not demonstrated to be associated with all-cause mortality by meta-analysis. The quality of evidence was deemed as either low or very low.ConclusionsThe presence of autoantibodies such as MPO-ANCA and ANA was demonstrated to be associated with the development of some autoimmune diseases for patients with IPF although there was no difference of all-cause mortality. However, the results should be interpreted with caution due to low evidence level.PROSPERO registration numberCRD42017077336.
Mixed-methods feasibility study of blood pressure self-screening for hypertension detection
Authors: Tompson Alice , Fleming Susannah , Lee Mei-Man , Monahan Mark , Jowett Sue , McCartney David , Greenfield Sheila , Heneghan Carl , Ward Alison , Hobbs Richard , McManus Richard J 
Published: May 2019

ObjectiveTo assess the feasibility of using a blood pressure (BP) self-measurement kiosk—a solid-cuff sphygmomanometer combined with technology to integrate the BP readings into patient electronic medical records— to improve hypertension detection.DesignA concurrent mixed-methods feasibility study incorporating observational and qualitative interview components.SettingTwo English general practitioner (GP) surgeries.ParticipantsAdult patients registered at participating surgeries. Staff working at these sites.InterventionsBP self-measurement kiosks were placed in the waiting rooms for a 12-month period between 2015 and 2016 and compared with a 12-month control period prior to installation.Outcome measures(1) The number of patients using the kiosk and agreeing to transfer of their data into their electronic medical records; (2) the cost of using a kiosk compared with GP/practice nurse BP screening; (3) qualitative themes regarding use of the equipment.ResultsOut of 15 624 eligible patients, only 186 (1.2%, 95% CI 1.0% to 1.4%) successfully used the kiosk to directly transfer a BP reading into their medical record. For a considerable portion of the intervention period, no readings were transferred, possibly indicating technical problems with the transfer link. A comparison of costs suggests that at least 52.6% of eligible patients would need to self-screen in order to bring costs below that of screening by GPs and practice nurses. Qualitative interviews confirmed that both patients and staff experienced technical difficulties, and used alternative methods to enter BP results into the medical record.ConclusionsWhile interviewees were generally positive about checking BP in the waiting room, the electronic transfer system as tested was neither robust, effective nor likely to be a cost-effective approach, thus may not be appropriate for a primary care environment. Since most of the cost of a kiosk system lies in the transfer mechanism, a solid-cuff sphygmomanometer and manual entry of results may be a suitable alternative.