bluuebunny/crossref_metadata_2025_split huggingface dataset:
Time to plateau as a predictor of survival in newly diagnosed multiple myeloma
Authors: Mellors Patrick W. , Binder Moritz , Buadi Francis K. , Lacy Martha Q. , Gertz Morie A. , Dispenzieri Angela , Hayman Suzanne R. , Kapoor Prashant , Gonsalves Wilson I. , Hwa Yi L. , Fonder Amie , Hobbs Miriam , Kourelis Taxiarchis , Warsame Rahma , Zeldenrust Steven R. , Lust John A. , Leung Nelson , Go Ronald S. , Kyle Robert A. , Vincent Rajkumar S. , Kumar Shaji K. 
Published: April 2018

AbstractResponse rates in newly diagnosed multiple myeloma have improved dramatically with the introduction of highly effective novel therapies. However, survival in patients achieving optimal responses to initial treatment can vary significantly, and new prognostic indicators are required to improve risk stratification. We investigated the relationship between time to plateau (TPlat) and survival in 1099 newly diagnosed patients treated with novel agents at our institution from 2005 to 2015.TPlatwas defined as time from initiation of first‐line therapy to best response to first‐line therapy. The medianTPlatwas 4.9 months (0.7‐58.6) and plateau duration was 1.8 years (0.2‐11.0). Patients who required > 120 days to achieve a plateau had longer modified overall survival (mOS) and progression free survival (mPFS) calculated from a landmark of best response (P < .001 for both comparisons). Statistically significant improvement in mOS was retained in subgroup analysis based on age and whether patients received upfront autologous hematopoietic stem cell transplantation (ASCT) (P < .001 for all comparisons). Our results suggest that patients who respond more gradually to initial therapy (TPlat > 120 days) experience longer survival compared to more rapid responders. Patients with a prolongedTPlatcould represent an “ongoing responder” phenotype that portends a survival advantage independent of treatment with upfront ASCT, depth of response, and biologic markers such as ISS stage and cytogenetic risk.
The changing face of adult posttransplant lymphoproliferative disorder: Changes in histology between 1999 and 2013
Authors: Tsai Donald E. , Bagley Stephen , Reshef Ran , Shaked Abraham , Bloom Roy D. , Ahya Vivek , Goldberg Lee , Chung Albert , Debonera Fotini , Schuster Stephen J. , Huntington Scott F. 
Published: April 2018

AbstractPosttransplant lymphoproliferative disorder (PTLD) typically presents with either polymorphic or monomorphic histology. While both are the end result of immunosuppressive therapies, their origins are felt to be different with different prognoses and responsiveness to therapy, resulting in 2 different malignancies. We attempted to confirm reports suggesting that the relative frequency of these 2 histologies is shifting over time. We analyzed 3040 adult PTLD cases in the UNOS OPTN database from 1999 to 2013. Changes in PTLD cases over time were analyzed for histology, time from transplant to diagnosis, and patient EBV serostatus. We found that the relative proportion of polymorphic versus monomorphic histology has changed with an increase in the proportion of monomorphic cases with time (1999‐2003, 54.9% vs. 45.1%; 2004‐2008, 58.3% vs. 41.7%; 2009‐2013, 69.7% vs. 30.3%; P = <.001). The change is driven by a gradual increase in the number of monomorphic PTLD with a steady number of polymorphic PTLD. The change is most strongly seen in transplant recipients who were EBV serostatus positive at the time of transplant. Potential causes are changes in immunosuppressive regimens with increased tacrolimus use (P = .009) and increased survival among transplant patients leading to later occurrence of PTLD (P = .001) that have occurred during the time frame analyzed. As organ transplantation has evolved over time, PTLD has coevolved. These changes in histology have important implications regarding the origin and clinical management of PTLD.
“Respect for each gender”: Gender, equity and backlash in Australia's male health policy
Authors: Seymour Kate 
Published: April 2018

AbstractAustralia is one of the few countries which has specific health policies for boys/men and girls/women as distinct groups. In this article I present an analysis of the discourses of gender, equity and disadvantage drawn upon in Australia's men's health policy. Through comparison with the women's health policy, I show that a dual focus on the essential differences between men and women and the ways in which the health system has failed men contribute to an adversarial gender politics, positioning men and women as rivals with competing needs. Reflecting broader debates concerning the negative impact of societal change on boys/men, I argue that, in its current form, Australia's health policy both taps into and, crucially, legitimises backlash politics, enabling it to ‘pass’ as sound public policy.
Palladium‐Catalyzed Insertion of Isocyanides into the C−S Bonds of Heteroaryl Sulfides
Authors: Otsuka Shinya , Nogi Keisuke , Yorimitsu Hideki 
Published: April 2018

AbstractInsertion of tert‐butyl isocyanide into the C(sp2)−S bonds of heteroaryl sulfides is catalyzed by a palladium diphosphine complex. Thioimidates generated through this reaction could be readily hydrolyzed under acidic conditions to yield the corresponding thioesters, which are of synthetic use. This insertion is useful because starting heteroaryl sulfides were readily prepared by either conventional ways or through sulfur‐specific extended Pummerer reactions.
A General, Activator‐Free Palladium‐Catalyzed Synthesis of Arylacetic and Benzoic Acids from Formic Acid
Authors: Wang Lin , Neumann Helfried , Beller Matthias 
Published: April 2018

AbstractA new catalyst for the carboxylative synthesis of arylacetic and benzoic acids using formic acid (HCOOH) as the CO surrogate was developed. In an improvement over previous work, CO is generated in situ without the need for any additional activators. Key to success was the use of a specific system consisting of palladium acetate and 1,2‐bis((tert‐butyl(2‐pyridinyl)phosphinyl)methyl)benzene. The generality of this method is demonstrated by the synthesis of more than 30 carboxylic acids, including non‐steroidal anti‐inflammatory drugs (NSAIDs), under mild conditions in good yields.
Photomechanically Induced Magnetic Field Response by Controlling Molecular Orientation in 9‐Methylanthracene Microcrystals
Authors: Tong Fei , Xu Wenjing , Al‐Haidar Maram , Kitagawa Daichi , Al‐Kaysi Rabih O. , Bardeen Christopher J. 
Published: April 2018

AbstractA surfactant‐assisted seeded‐growth method is used to form single‐crystal platelets composed of 9‐methylanthracene with two different internal molecular orientations. The more stable form exhibits a photoinduced twisting, as observed previously for 9‐methylanthracene microribbons grown by the floating drop method. However, the newly discovered elongated hexagonal platelets undergo a photoinduced rolling‐up and unrolling. The ability of the rolled‐up cylindrical shape to trap superparamagnetic nanoparticles enables it to be carried along in a magnetic field gradient. The new photoinduced shape change, made possible by a novel surfactant‐assisted crystal growth method, opens up the possibility of using light to modulate the crystal translational motion.
Flame retardancy for cotton cellulose treated withH3PO3
Authors: Lee Hong Chan , Lee Shichoon 
Published: April 2018

ABSTRACTThe flame retardancy of cotton fabrics has been improved with treatment of phosphorous aqueous solution. In this study, cotton cellulose is treated with simple treatment and benign chemicals including an aqueous H3PO3solution dipping and heat annealing. The flame retardancy of the H3PO3treated cotton fabrics is enhanced to the degree that it is non‐flammable. Thermogravimetric analysis results show that the residue increased up to about 50% at 800 °C by the treatment. Scanning electron microscopy exhibit some disconnection of fibers and the fibers are fragile. X‐ray diffractometry reveal little damage to the crystalline structure of cellulose. Fourier transform infrared spectroscopy and X‐ray photoelectron spectroscopy show some portion of the added H3PO3reacted with cellulose components to be phosphorylated and dehydrated. The resulting data and analysis demonstrate that these dehydrated and phosphorylated moieties formed by treatment of phosphorous solution help accelerate the formation of char components, resulting in improved flame retardancy of cellulose materials. © 2018 Wiley Periodicals, Inc. J. Appl. Polym. Sci.2018,135, 46497.
Synthesis and performance measurement of environment‐friendly solidified dust suppressant for open pit coalmine
Authors: Zhang Haihan , Nie Wen , Liu Yanghao , Wang Hongkun , Jin Hu , Bao Qiu 
Published: April 2018

ABSTRACTIn this work, a new type of environment‐friendly solidified dust suppressant was developed to solve the dust pollution problem in open pit coalmines, coal bunkers, and so on. Natural polymer chitosan with excellent properties was chemically modified. Infrared spectroscopy was adopted to characterize the product. Using substitution rate as the evaluating indicator, the optimized mass ratio between monomer 3‐chloro‐2‐hydroxypropyl trimethyl ammonium chloride and chitosan, reaction temperature, reaction time, and pH were determined via single factor experiments. Combining the results of the four‐factor‐four‐level orthogonal experiment, the optimum reaction conditions A2B3C4D3 were obtained. The hardened film on the surface of coal powders was observed by high‐resolution scanning electron microscope. In addition, the water retention, solidification performance, and wind erosion resistance of the dust suppressant, as well as its influence on coal properties were measured. The results show that the synthesized dust suppressant demonstrates excellent properties and has good dust suppression effect. © 2018 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2018, 135, 46505.
Copolymers of poly(arylene sulfide sulfone)/poly(ether sulfone): Synthesis, structure, and rheology properties
Authors: Yan Guang‐Ming , Hu Quan , Zhang Gang , Ren Hao‐Hao , Lu Jie‐Hong , Yang Jie 
Published: April 2018

ABSTRACTIn order to overcome the poor flowability of poly(arylene sulfide sulfone) (PASS), we introduced ether bonds into the polymer main chain. A series poly(arylene ether sulfide sulfone) copolymers (PAESS) containing different proportion of ether bonds were synthesized with 4,4′‐dichlorodiphenyl sulfone (DCDPS), sodium sulfide (Na2S·xH2O), and 4,4′‐dihydroxydiphenyl ether (DHDPE). The copolymers were characterized by Fourier transform infrared (FTIR), 1H‐nuclear magnetic resonance (NMR), differential scanning calorimetry, dynamic mechanical analysis (DMA), and rheometer. The results of FTIR and 1H‐NMR indicate the copolymers are synthesized successfully. PAESS were found to have excellent thermal properties with glass transition temperature (Tg) of 175.7–219.1 °C and 5% weight lost temperature were all above 420 °C. The tensile and DMA test indicates that these resultant copolymers have good mechanical properties with tensile strength of 60 MPa and storage modulus of 1.5 GPa. From the results of rheology properties testing, we found that the melt stability and melt flowability of PASS were improved distinctly from 25,470 Pa s down to 355 Pa s with the incorporation of ether bonds. That will be quite beneficial to the processing of PASS, especially for the thermoforming of precision products. © 2018 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2018, 135, 46534.
Employment of ultrasonic waves for the preparation of PVA/TiO2‐BSA nanocomposites: Mechanical, thermal, and optical properties
Authors: Mallakpour Shadpour , Shamsaddinimotlagh Sima 
Published: April 2018

ABSTRACTThe goal of this project is to obtain poly(vinyl alcohol) (PVA)/TiO2‐bovine serum albumin (BSA) nanocomposite (NC) films in different weight percentages of modified TiO2. For this purpose, to prevent the accumulation of nanoparticles (NPs) in the PVA matrix, the surface of the TiO2 NPs was treated with the BSA molecules. To achieve this aim, ultrasonic waves were used as an environmentally friendly and green process that decrease the time of reactions, help better spreading of TiO2 NPs and maintain dimensions of TiO2 NPs in the nanoscale range. In the end, the features of the PVA/TiO2‐BSA NC films were considered with a variety of techniques. The Fourier transform infrared spectroscopy, energy dispersive X‐ray, and X‐ray diffraction showed that the BSA was well placed on the surface of TiO2 NPs. The thermal gravimetric analysis and UV‐visible results demonstrated that all the PVA/TiO2‐BSA NC films have better thermal and optical properties than the pure PVA. © 2018 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2018, 135, 46558.
The Cochlear Spiral Ganglion Neurons: The Auditory Portion of the VIII Nerve
Authors: Carricondo Francisco , Romero‐Gómez Bárbara 
Published: April 2018

ABSTRACTThe VIII nerve is formed by sensory neurons that innervate the inner ear, i.e., the vestibular and the auditory receptors. Neurons of the auditory portion, the cochlear afferent fibers that innervate the sensory hair cells of the organ of Corti, have their somas in the cochlear spiral ganglion where two types of neurons can be distinguished. Afferent Type‐I neurons are the 95% of the total population. Bipolar and myelinated fibers, each one innervates only one cochlear inner hair cell (IHC). In contrast, afferent Type‐II neurons are only the 5% of the spiral ganglion population. They are pseudounipolar and unmyelinated fibers and innervate the cochlear outer hair cells (OHC) so that one afferent Type‐II fiber contacts with multiple OHCs, but each OHC only receives one contact from one Type‐II neuron. Both types of VIII nerve fibers are glutamatergic, but these asymmetric innervations of the cochlear sensory cells could suggest that the IHC codifies the truly auditory message but the OHC only informs about mechanical aspects of the state of the organ of Corti. In fact, the central nervous system (CNS) has control over the information transmitted by the Type‐I neuron by means of axons from the superior olivary complex that innervate them to modulate, filter and/or inhibit the entry of auditory message to CNS. The aim of this paper is to review the current knowledge about the anatomy and physiology of the auditory portion of the VIII nerve. Anat Rec, 302:463–471, 2019. © 2018 Wiley Periodicals, Inc.
Cranial Pair I: The Olfactory Nerve
Authors: Crespo Carlos , Liberia Teresa , Blasco‐Ibáñez José Miguel , Nácher Juan , Varea Emilio 
Published: April 2018

ABSTRACTThe olfactory nerve constitutes the first cranial pair. Compared with other cranial nerves, it depicts some atypical features. First, the olfactory nerve does not form a unique bundle. The olfactory axons join other axons and form several small bundles or fascicles: the fila olfactoria. These fascicles leave the nasal cavity, pass through the lamina cribrosa of the ethmoid bone and enter the brain. The whole of these fascicles is what is known as the olfactory nerve. Second, the olfactory sensory neurons, whose axons integrate the olfactory nerve, connect the nasal cavity and the brain without any relay. Third, the olfactory nerve is composed by unmyelinated axons. Fourth, the olfactory nerve contains neither Schwann cells nor oligodendrocytes wrapping its axons. But it contains olfactory ensheathing glia, which is a type of glia unique to this nerve. Fifth, the olfactory axons participate in the circuitry of certain spherical structures of neuropil that are unique in the brain: the olfactory glomeruli. Sixth, the axons of the olfactory nerve are continuously replaced and their connections in the central nervous system are remodeled continuously. Therefore, the olfactory nerve is subject to lifelong plasticity. Finally seventh, the olfactory nerve can be a gateway for the direct entrance of viruses, neurotoxins and other xenobiotics to the brain. In the same way, it can be used as a portal of entry to the brain for therapeutic substances, bypassing the blood‐brain barrier. In this article, we analyze some features of the anatomy and physiology of the first cranial pair. Anat Rec, 302:405–427, 2019. © 2018 Wiley Periodicals, Inc.
The Human Laryngeal Innervation Revisited—The Role of the Neural Connections
Authors: Martín‐Oviedo Carlos , Maranillo Eva , Sañudo José Ramón , Pérez‐Lloret Pilar , Verdú Enrique , Martínez‐Guirado Tomas , Álvarez‐Montero Oscar , Gómez Martín‐Zarco Jose Manuel , Vázquez Teresa 
Published: April 2018

ABSTRACTIn spite that vascular inconvenients or immunological rejections have been solved in relation with larynx transplant, a successful functional reinnervation has not been achieved. Some studies have suggested that laryngeal nerve connection may contain motor fibers, which could explain unexpected evoked responses in electromyographic studies or the different positions adopted of the vocal folds after similar nerve lesions. Ten patients with unexpected evoked responses after laryngeal nerve stimulation were selected. All the patients underwent a total laryngectomy due to oncological causes. In every case, laryngeal nerve connections were observed. All of them were morphologic and histologic processed for choline‐acetyltransferase immunohistochemistry. The presence of motor axons in the nerve connections has been demonstrated, which would explain that the motor innervation to the laryngeal muscles could be dual through these variable connections. This also would justify the difficulty of carrying out laryngeal nerve reinnervation procedures. Anat Rec, 302:646–651, 2019. © 2018 Wiley Periodicals, Inc.
Neurovascular Relations of the Trigeminal Nerve in Asymptomatic Individuals Studied with High‐Resolution Three‐Dimensional Magnetic Resonance Imaging
Authors: Ruiz‐Juretschke Fernando , González‐Quarante LaíN H. , García‐Leal Roberto , Martínez de Vega Vicente 
Published: April 2018

ABSTRACTNeurovascular compression (NVC) is considered the main cause of classic trigeminal neuralgia (TN) and may be surgically addressed with microvascular decompression (MVD). Preoperative high‐resolution three‐dimensional magnetic resonance has proven a reliable tool to diagnose NVC in patients with refractory TN undergoing MVD. However, there is still scarce data regarding the rate, degree, and characteristics of neurovascular compression in asymptomatic individuals. This article describes the vascular relations of the trigeminal nerve in the cerebellopontine angle (CPA) in 100 subjects without known TN studied with 3.0T FIESTA (Fast Imaging Employing Steady‐state Acquisition) MRI sequence. A NVC was observed in 142 (71%) of the 200 nerves with a 75% rate of bilateral NVC. Of the nerves with NVC, 92.3% showed a mere contact (Grade 1) without distortion and 78% occurred at the cisternal segment. This most common vessel causing the NVC was a vein (66%) followed by the superior cerebellar artery (28%). No significant reduction in diameter suggesting atrophy was seen in the nerves with NVC. The results indicate a high rate of mild, distal and predominantly venous vascular contact with the trigeminal nerve at the CPA in asymptomatic individuals. This clearly contrasts with the usual pattern of NVC observed in TN that is generally a severe, proximal, and arterial compression. Knowledge about the frequent NVC in asymptomatic individuals and its features is essential for interpreting preoperative MRI in patients with refractory classical TN considered for surgery. Anat Rec, 302:639–645, 2019. © 2018 Wiley Periodicals, Inc.
Thermisch‐energetische Gebäudesimulation auf Basis eines Bauwerksinformationsmodells
Authors: Benz Alexander , Taraben Jakob , Lichtenheld Thomas , Morgenthal Guido , Völker Conrad 
Published: April 2018

AbstractFür eine Abschätzung des Heizwärmebedarfs von Gebäuden und Quartieren können thermisch‐energetische Simulationen eingesetzt werden. Grundlage dieser Simulationen sind geometrische und physikalische Gebäudemodelle. Die Erstellung des geometrischen Modells erfolgt in der Regel auf Basis von Bauplänen oder Vor‐Ort‐Begehungen, was mit einem großen Recherche‐ und Modellierungsaufwand verbunden ist. Spätere bauliche Veränderungen des Gebäudes müssen häufig manuell in das Modell eingearbeitet werden, was den Arbeitsaufwand zusätzlich erhöht. Das physikalische Modell stellt die Menge an Parametern und Randbedingungen dar, welche durch Materialeigenschaften, Lage und Umgebungseinflüsse gegeben sind. Die Verknüpfung beider Modelle wird innerhalb der entsprechenden Simulationssoftware realisiert und ist meist nicht in andere Softwareprodukte überführbar. Mithilfe des Building Information Modeling (BIM) können Simulationsdaten sowohl konsistent gespeichert als auch über Schnittstellen mit entsprechenden Anwendungen ausgetauscht werden. Hierfür wird eine Methode vorgestellt, die thermisch‐energetische Simulationen auf Basis des standardisierten Übergabeformats Industry Foundation Classes (IFC) inklusive anschließender Auswertungen ermöglicht. Dabei werden geometrische und physikalische Parameter direkt aus einem über den gesamten Lebenszyklus aktuellen Gebäudemodell extrahiert und an die Simulation übergeben. Dies beschleunigt den Simulationsprozess hinsichtlich der Gebäudemodellierung und nach späteren baulichen Veränderungen. Die erarbeitete Methode beruht hierbei auf einfachen Modellierungskonventionen bei der Erstellung des Bauwerksinformationsmodells und stellt eine vollständige Übertragbarkeit der Eingangs‐ und Ausgangswerte sicher.
Steroid‐Based Amphiphiles for Membrane Protein Study: The Importance of Alkyl Spacers for Protein Stability
Authors: Ehsan Muhammad , Das Manabendra , Stern Valerie , Du Yang , Mortensen Jonas S. , Hariharan Parameswaran , Byrne Bernadette , Loland Claus J. , Kobilka Brian K. , Guan Lan , Chae Pil Seok 
Published: April 2018

AbstractMembrane proteins allow effective communication between cells and organelles and their external environments. Maintaining membrane protein stability in a non‐native environment is the major bottleneck to their structural study. Detergents are widely used to extract membrane proteins from the membrane and to keep the extracted protein in a stable state for downstream characterisation. In this study, three sets of steroid‐based amphiphiles—glyco‐diosgenin analogues (GDNs) and steroid‐based pentasaccharides either lacking a linker (SPSs) or containing a linker (SPS‐Ls)—have been developed as new chemical tools for membrane protein research. These detergents were tested with three membrane proteins in order to characterise their ability to extract membrane proteins from the membrane and to stabilise membrane proteins long‐term. Some of the detergents, particularly the SPS‐Ls, displayed favourable behaviour with the tested membrane proteins. This result indicates the potential utility of these detergents as chemical tools for membrane protein structural study and a critical role of the simple alkyl spacer in determining detergent efficacy.