bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Effects of Special Patient Population Plasma on Pharmacokinetic Quantifications Using LC-MS/MS
Authors: Zhou Dongmei , Sun Lifang , Nguyen Mai , Yeh Li- Tain , Wilson David M. 
Published: October 2019

Background:
Clinical development of lesinurad, a selective uric acid reabsorption inhibitor,
required analysis of lesinurad in plasma from special patient populations.

Methods:
EMA and FDA bioanalytical method validation guidance have recommended studying matrix
effects on quantitation if samples from special patient populations are to be analyzed. In addition to
lesinurad (plasma protein binding 98.2%), the matrix effects from special population plasma on the
quantitation of verapamil (PPB 89.6%), allopurinol and oxypurinol (PPB negligible) were also investigated.

Results:
The plasma from special population patients had no matrix effects on the three quantification
methods with stable isotope labeled internal standard, protein precipitation extraction, and LC-MS/MS
detection. The validated lesinurad plasma quantification method was successfully applied for the pharmacokinetic
evaluations to support the clinical studies in renal impaired patients.

Conclusion:
Special population plasma did not affect quantitation of drugs with a wide range of
plasma protein binding levels in human plasma. With the confirmation that there is no impact on quantification
from the matrix, the bioanalytical method can be used to support the pharmacokinetic evaluations
for clinical studies in special populations.
Managing Acute Agitation and Psychotic Symptoms in the Emergency Department
Authors: Moukaddam Nidal , Choi Raymond , Tucci Veronica 
Published: October 2019

Background and goals:It is fairly common for adolescents with a presenting problem of acute agitation to present to the Emergency Department. These patients present challenges with respect to both differential diagnosis and management. Furthermore, with many adolescents having extended stays in emergency departments, it is important for ED physicians to have a basic familiarity with diagnosis and treatment.Method:In this paper, we present a primer on the conditions underlying acute agitation and review approaches to management in the emergency department.Discussion:Psychotic disorders, such as schizophrenia, are distinct from other conditions presenting with psychotic symptoms, which can range from depression to substance use to non-psychiatric medical conditions. Agitation, a state of excessive verbal and physical activity, can accompany any of these conditions. Unlike the case for adults, practice guidelines do not exist, and there is no fully agreed upon expert consensus yet. Emergency physicians should have a working knowledge of antipsychotic medications and need to consider pharmacological as well as non-pharmacological treatments for optimal management.
Embodied Cognition and Language Appropriation: Recycling with Difference by a Child with Congenital Deafblindness and Multiple Disability
Authors: Costain Kirsten , Souriau Jacques , Daelman Marlene 
Published: October 2019

This article uses microanalysis of a video case example of embodied cognition and language appropriation in a child with congenital deafblindness and multiple disability. The creative and generative nature of the child’s expressions are highlighted in this analysis in an exploration of the dialogical concept of recycling (Linell, 2010), in particular recycling with difference (Anward, 2004; 2014). The central notion of simulation in cognition is challenged here by highlighting the status of the child’s expressions as re-workings rather than representations or copies of the original interaction. The account of the micro-analysis of alignment in the case is linked to the cognitive-linguistic perspective of dialogic syntax with its key notions of parallelism, resonance and engagement.
https://doi.org/10.21827/jdbsc.5.32572
El deslizamiento de la identidad: entre política y subjetividad
Authors: Gutiérrez Castañeda Griselda 
Published: October 2019

Through the analyze of documentary Trazando Aleida. La historia de una búsqueda, which is an approach of the Mexican dirty war in the ’70s, through the experience of some victims, we have the opportunity to show the abundant possibilities of dialogue between cinema and philosophy, The approach to complex subjects in philosophy, usually is by means of systematical argumentative and critical constructions, while the cinematic part show with fragments of images, of parliaments, achieving condense these subjects. With this condensation could perform, social, subjectivity, political, and historical reality, playing with image, sound, interpretation, and creation. Therefore the philosophy could have a rich platform of reflection in dialogue with the cinema. The dialogue with this excellent documental, as a laboratory, some philosophical thesis acquiring density, thesis-like no-complete constitution of subjectivity, and the political conflict like the horizon of possibility/impossibility of identity process. This essay is an attempt to show that the density of arguments embody in life experience, and those become a profound and painful radical experience.
Reforma y Contrarreforma. El debate teológico en el umbral de la nueva ciencia
Authors: Velázquez Zaragoza Alejandra 
Published: October 2019

The theological debate that gave rise to the religious Reformation undertaken by Luther, extended to the epistemological problematic of the new science. The controversy between Reformers and Counter-reformers in the search for the correct reading of the Holy Scriptures -either from the sources or from the doctrine-, led to the rethinking of the problem of the criterion or norm of truth to establish the correct reading and the method of interpretation to reach the revealed truth of the sacred scriptures. The problem of the criterion not only had an impact on the religious sphere, when transferred to the field of natural philosophy, forced the impostors of the new science to take positions around its epistemic status: approximate truths (moral certainty) or absolute truths (metaphysical certainty). Here the above-mentioned panorama is exposed, to make clear the correlation between the theological and the epistemological querella that, in one of its main angles, can be stated as the opposition to authority, whether to the papal —like Luther— or to the tradition scholastic, in the manner of Galileo. In both cases it is required to go to the source: the sacred book or the one of nature.
La filosofía clásica alemana es obra de teólogos encubiertos: el protestantismo en la génesis del idealismo alemán
Authors: López Domínguez Virginia 
Published: October 2019

Schopenhauer and Nietzsche pointed out that the classical German Philosophy was the expression of a covert Theology. In fact, from Lessing to Hegel, through Kant, trough the Idealists and the Romantics, German philosophers and thinkers studied in protestant schools and seminaries, for the most part, of pietist orientation. This article shows the general characteristics of pietism and how it influenced the problems statement, the doctrines and ideas of some of these philosophers.
PROGRAM PENGEMBANGAN BUDAYA KEWIRAUSAHAAN BAGI MAHASISWA PERGURUAN TINGGI MELALUI KETERAMPILAN PERCETAKAN
Authors: Rubiyanto Rubino 
Published: October 2019

Untill predominate out-comes of the College are job seeker. Tochange the mind set them to become the job creator presumably need aneffort, stock purchasing and giving of capital entrepreneur. Therefore noits bad if the student FKIP to made as a professional teacher candidate,also given entrepreneur lecturer. This lecturer is programmed in anpackage: KWU in the field of offset printing skill. Target of this activity is:(a) develop the culture of entrepreneur in PT, (b) the student have thestock of science and skill of offset printing area, (c) student have theknowledge about trick of the trade, developing idea of effort, managingeffort, marketing strategy and obtain;get the capital employed, (d)student have the readiness of business. The target of this activity are 30student’s of FKIP in semester VI from various program. Lecturing methodcover the discourse, discussion, duty, question and answer, compilationof proposal business, seminar proposal, simulation and also practice inprinting office. Resistance met by execution KWU at the same time bylecturer fundamental so that execution entrepreneur delayed. Finally theenterpreur program are executed after even semester test 2006 finishing.Activity exterior for example; 1) piled up over by module entrepreneur,vision of business mission, career tuition, credit system of this effort; 2)piled up over by proposal business in group; 3) the expected after studentpass, 25 % participant earn the entrepreneur offset printing.
PAKOM PENGEMBANGAN RENCANA PELAKSANAAN PEMBELAJARAN (RPP) BERDASARKAN KURIKULUM 2013 DI PCM KECAMATAN MATESIH KARANGANYAR
Authors: Santoso Joko , Rahmawati Laili Etika , Muhroji Muhroji , Pradana Rizka Rahma , Untari Rina 
Published: October 2019

This public service has aim to give knowledge for the MIM’s teachers in Matesih subregency about the curriculum of 2013 paradigm, continued profession development, and the lesson plan development based on the curriculum of 2013. The strategies used to pursue the goals were: (1) discussion: in the beginning of the activities, all ofthe participants were seated in a room to get the knowledge of curriculum 2013 paradigm and the continued profession development. After the presentation delivered by the speaker has finished, the participants conducted the discussion with the speaker related to the knowledge which had not been understood yet; (2) the lesson planworkshop: after the discussion finished, the participants were divided into two groups. The division of the groups based on the class grade, they were class 1, 2, and 3 belonging to the first group while the class 4, 5, and 6 were belonging to the second group. Every group was guided by an instructure to give gudance for the participantsto understand the lesson plan format based on the curriculum of 2013 and asked to practice the lesson plaan arranging. The result of the competitive social service program (PAKOM) for the MIM’s teachers in Matesih subregency can be stated as successful. The indication was the target reached e.i. 100% of the teachers couldconstruct the lesson plan based on the curriculum of 2013.
Epidemiological Study of Hepatitis B, C and HIV Cases among the Foreigners Visiting Sulaimani City from 2013 Through 2016
Authors: Omer Mohammed Mohammed , Baram Hasan Asan , Bakir Maarouf Fenk 
Published: October 2019

Hepatitis B, C and HIV infections present a great public health problem worldwide. More than 350 million of world's populations have chronic HBV infection and near 1 million people are dying due to this infection each year. About 150-200 million of world's population have chronic HCV infection that leads to nearly 350 000 deaths annually. On the other hand HIV remains as a major global public health issue. In 2015, about 36.7 million people were living with HIV and 1.1 million people died of HIV related illnesses.
To find the prevalence of HB, HCV and HIV infection among the foreigners who visited Sulaimani city in 2013 through 2016 and evaluate the common risk factors in those who had a positive results in 2016. This study was conducted between 1stof January 2016 and 31st December 2016. A total number of 275,979 foreigners who were referred formally to the central laboratory- residency department in Sulaimani city for screening for (HBsAg, HCV Ab and HIV Ab) from 2013 through 2016 were analyzed and all the foreigners who visited Sulaimani city in 2016 were included with assessment of demographic data and risk factors among the positive cases. Among 275,979 foreigners who visited Sulaimani city from 2013 through 2016, theoverall prevalence of HBV infection was0.47%(1318 cases), HCV 0.01 %( 267 cases) and HIV 0.01 %( 30 cases). In 2016 the highest prevalence of HBV infection was among Syrians which was 2.5% while highest HCV prevalence was among Europeans 0.82%. Ages of the patients ranged between (18-65) years, 85.4% were males, 65.2% of males and 45.7% of females were married. Dental procedures, surgery, blood transfusion and family history were common risk factors.
HBV infection was highest among Syrian foreigners. While the highest HCV prevalence was among Europeans. An immediate action plan is needed to screen all Syrian refugees in our region for HBV, HCV and HIV to determine active infection and treat accordingly and also impose preventive measures to halt the spread of the infections.
Celluloid is Not a Signifier Any More
Authors: Štrajn Darko 
Published: October 2019

Nowadays art does not necessarily need to be militant or socially involved to be political since the categories of truth and reality are destroyed through the mediatic dissipation of notions of subjectivity and objectivity. Since the first obvious indications of the inception of the times of the “end of representation” – as Deleuze pointed out half a century ago – we have to deal with a widespread awareness about the persevering change of art and of reflections about art in the social framework of institutional and technological contexts. The analysis of interactions, starting with the invention of film/cinema, artistic practice and theory, including aesthetics, highlights the importance of the notions, categories and agencies of movement. The emergence of the so-called post-media epoch signals a new decisive change following the one, which was revealed as the overwhelming onset of mass culture. As the theoretical indecision about the features of an ongoing new change seems to be still dominant, the practice of art of any conceivable variety reflects basically the same indecision. The fact that ‘film’ is still the notion, which by and large means moving images, while digitalization made the material (celluloid) film obsolete, is an elementary metaphor of the process of the vanishing of signifiers, related to the notion of art. However, in a more complex term, the questions about the correlation between form and content are re-emerging in novel configurations as well as the epistemological and ontological problems of aesthetics, concerning the designations of objects of analysis.

Article received: May 17, 2019; Article accepted: July 6, 2019; Published online: October 15, 2019; Original scholarly paper
As the ‘Intellectual Subject’ of Artificial Intelligence – The Intrinsic Understanding of Artificial Intelligence on The Ideas of ‘Time’ and ‘Space’
Authors: Tianyu Shi 
Published: October 2019

Presupposing artificial intelligence (AI) is an ‘intellectual subject’ rather than merely a product of complex operation is a prerequisite to discussing how AI and human intelligence inherently understand time and space. This article argues that AI as an intellectual subject and human intelligence have their respective origins and connotations, and different intelligent characteristics also lead to the difference between them in the way of inherently understanding time and space; different inherent understandings of time and space and whether to think with time and space as an ‘object’ are the underlying differences between AI and human intelligence. Meanwhile, so far AI is unable to process space-time issues by means of ‘non-objectification’.

Article received: April 26, 2019; Article accepted: July 6, 2019; Published online: October 15, 2019; Original scholarly paper
Can AR Technologies Have an Impact on the Definition of Art?
Authors: Higashiguchi Yutaka 
Published: October 2019

AR seems to be one of the most advanced and near-future technologies that produce new experiences and values that have never been before. However, both AR and art have a common means of engaging the senses. Thus, the problem of where the borderline between AR and art exists should come into question. In order to consider how AR will have an influence on the definition and the significance of art, this study analyses real and fictional elements in AR and art. AR requires the physical field where sensory information mediated by computer is projected. Consequently, viewers perceive the mixed image of real things and those not existing before eyes, that is fiction. Art also needs a real environment where the fictional world is opened. Though art and AR have something in common, there are crucial differences between them. AR technologies include the firm aim of erasing fictional elements that remain as ever in spite of their accurate representation. On the other hand, art attempts to preserve a fictional area within the real world. From the comparison of AR and art, it will come to light that whether there is the frame or not plays an important role in deciding what is art or what is reality. While AR reduces fictionality from a multi-layered scene to enrich a real experience, art cuts fiction from a present scene to idealize the real world. In this way, they constitute a dialectical circle and mediate new reality through fictional images from the reverse direction.

Article received: April 5, 2019; Article accepted: July 6, 2019; Published online: October 15, 2019; Review article
Can Artworks by Artificial Intelligence be Artworks?
Authors: Park Yeonsook 
Published: October 2019

The thinking power of Homo sapiens made human beings the lord of all creation. The ability to reason is also the premise of human existence. We, however, now know that this is not confined only to human but to Artificial Intelligence. Over the history of humankind, human beings have attempted to create an immortal being that could surpass their abilities and complements their inferiorities. We are making something immortal and transcendent, which are different properties from our own. Artificial Intelligence may be able to evolve on its own like humans have been doing. As a kind of numerical being, humans are able to be omnipresent with the technology provided. This new kind of existence makes us think about and see things differently. Humans are attempting to create ‘beings’ that can generate art, take care of weak human beings, talk and discuss human issues, and even fall in love with humans. As our minds can run beyond the boundaries created by our body limitations, we would like to infuse our creativity into AI that might evolve from its original state. Similar to what Prometheus did, humans are attempting to share their legacy with another existence. Recently a research team from Rutgers University in New Jersey proposed a system named CAN: Creative Adversarial Networks for generating art with creative characteristics. The team demonstrated a realization of this system based on a novel, creative adversarial network. Their proposed system possesses the ability to produce novel artworks which make people believe human artists produced them. The data the team proposes proves that AI now attempts to do something considered as a creative activity. With this research, the definition of art should be reconsidered. Since the Fountain(1917) by Duchamp, open concepts toward artworks have been embraced by many artists and their colleagues. However, it is time to contemplate the new phase. When we regard something as artwork, should it be created, selected, and combined by human beings? Is it possible that the thing that is accepted as artwork by people can be art? This paper seeks to propose several opinions regarding these questions.

Article received: June 23, 2019; Article accepted: July 6, 2019; Published online: October 15, 2019; Review article
Monetary Symbolism: Art as a Deposit of Value
Authors: Vojvodić Balaž Violeta 
Published: October 2019

MONEY – a unit of account, a deposit of value, and a medium of exchange – formally evolved from grain, precious metal, cheap paper, to state-of-the-art digital accounting records managed by artificial intelligence. Although the economists of the 19th century believed in its neutrality, money is an ambiguous socio-economic phenomenon which serves as a political tool and a measure of value even if its own value is volatile. The stamp of authority marked the symbolization of money as a cultural artifact: the character of a ruler, a symbol, or an inscription on the coin came to be a signifier of value. Accordingly, the financial system raised artistic concerns when money began to be an abstraction, i.e., a symbolic paper which acquires legitimacy via social consensus and constructs its value on the underlying commodity or the performances of the economic system. Starting from the similarities between Artistic and Monetary simulacrum and the fact that artwork functions as a deposit of cultural and financial value, this paper will discuss the artistic use of monetary symbolism from the early examples of satirical prints in The Great Mirror of Folly (1720) triggered by the speculation with one of the first European official paper currencies, to Duchamp’s art experiments with the securities and contemporary art research practice based on financial aesthetics.

Article received: April 5, 2019; Article accepted: July 6, 2019; Published online: October 15, 2019; Original scholarly paper
Adapting the Dynamic, Recursive Model of Sport Injury to Concussion: An Individualized Approach to Concussion Prevention, Detection, Assessment, and Treatment
Authors: Schneider Kathryn J. , Emery Carolyn A. , Black Amanda , Yeates Keith O. , Debert Chantel T. , Lun Victor , Meeuwisse Willem H. 
Published: October 2019

Synopsis The risk factors of concussion may be categorized as intrinsic (internal factors specific to the individual) or extrinsic (external factors related to the environment or sport). Identifying these factors is part of an individualized, patient-centered approach to prevention, assessment, and management of concussion. In most cases, the symptoms of concussion resolve in the initial few days following the injury, and a strategy involving a gradual return to sport and school is recommended. When symptoms persist for longer than 7 to 10 days, a multifaceted interdisciplinary assessment to guide treatment is recommended. This article applies the dynamic, recursive model of sport injury to sport-related concussion and summarizes the process of individualized assessment and management following concussion in athletes of all ages, with a focus on physical rehabilitation. J Orthop Sports Phys Ther 2019;49(11):799–810. doi:10.2519/jospt.2019.8926
MORFOLOGI VEGETATIF JENIS POHON TENGKAWANG (Shorea spp) DI DESA MENSIAU KECAMATAN BATANG LUPAR KABUPATEN KAPUAS HULU
Authors: Riska . , Manurung Togar Fernando 
Published: October 2019

Tengkawang is a Shorea tree which includes in Dipterocarpacea family. This tree was the indigenous species of West Kalimantan, and mostly found in Kapuas Hulu Regency. Tengkawang seed which is the mascot of West Kalimantan Province was used to produce vegetable oil, chocolate, medicine, margarine, candles, and cosmetics. One of the villages which famous on Tengkawang products were Mensiau village which located in Batang Lupar sub district, Kapuas Hulu Regency. The objective of research was to inventory the diversity of Tengkawang tree in Mensiau village, Batang Lupar sub district, Kapuas Hulu Regency, and identification and made a description on morphology of Tengkawang tree. The research was conducted from May until August 2017. The methods used exploration on four lines in the forest of Mensiau village. The research found total individuals of Tengkawang tree was 1,689 trees. There were five types of Tengkawang, namely Shorea stenoptera, Shorea beccariana, Shorea pinanga, Shorea seminis and Shorea macrophylla. The local names of Tengkawang in Mensiau village were Engkabang Tungkul, Engkabang Rambai, Engkabang Trindak, and Engkabang Biasa. The total individuals of Shorea stenoptera was 408 tree, Shorea beccariana was 571 tree, Shorea pinanga was 370 tree, Shorea seminis was 186 tree and Shorea macrophylla was 154 tree. The efforts on conservation of Tengkawang tree in Mensiau village was needed because the forest in the village was suitable for the habitat of Tengkawang. Keywords : Kapuas Hulu, Shorea beccariana, Shorea macrophylla, Shorea pinanga, Shorea seminis, Shorea stenoptera, Tengkawang