bluuebunny/crossref_metadata_2025_split huggingface dataset:
Vertical Profiles of the Wave-Induced Airflow above Ocean Surface Waves
Authors: Grare Laurent , Lenain Luc , Melville W. Kendall 
Published: October 2018

AbstractAn analysis of coherent measurements of winds and waves from data collected during the ONR Southern California 2013 (SoCal2013) program from R/P FLIP off the coast of Southern California in November 2013 is presented. An array of ultrasonic anemometers mounted on a telescopic mast was deployed to resolve the vertical profile of the modulation of the marine atmospheric boundary layer by the waves. Spectral analysis of the data provides the wave-induced components of the wind velocity for various wind-wave conditions. Results show that the wave-induced fluctuations depend both on the spectral wave age and the normalized height , where c is the linear phase speed of the waves with wavenumber k and is the mean wind speed measured at the height z. The dependence on the spectral wave age expresses the sensitivity of the wave-induced airflow to the critical layer where . Across the critical layer, there is a significant change of both the amplitude and phase of the wave-induced fluctuations. Below the critical layer, the phase remains constant while the amplitude decays exponentially depending on the normalized height. Accounting for this double dependency, the nondimensionalization of the amplitude of the wave-induced fluctuations by the surface orbital velocity collapses all the data measured by the array of sonic anemometers, where a is the amplitude of the waves.
SAR156597 in idiopathic pulmonary fibrosis: a phase 2 placebo-controlled study (DRI11772)
Authors: Raghu Ganesh , Richeldi Luca , Crestani Bruno , Wung Peter , Bejuit Raphael , Esperet Corinne , Antoni Christian , Soubrane Christina 
Published: October 2018

A phase 2b trial (NCT02345070) was conducted to evaluate the efficacy and safety of two dose levels/regimens of SAR156597 (a bispecific IgG4 antibody that binds and neutralises both circulating interleukin-4 and interleukin-13), in comparison with placebo, administered to patients with idiopathic pulmonary fibrosis (IPF) over 52 weeks.DRI11772 was a multinational randomised double-blind placebo-controlled phase 2b trial. Patients aged >40 years with a documented diagnosis of IPF received SAR156597 200 mg once every week (QW), SAR156597 200 mg once every 2 weeks (Q2W) or placebo, over 52 weeks. The primary efficacy end-point was absolute change from baseline in forced vital capacity (FVC) % predicted at 52 weeks.Of 327 randomised patients, 325 received treatment with placebo (n=109), SAR156597 Q2W (n=108) or SAR156597 QW (n=108). The mean change from baseline in FVC % pred at 52 weeks was –5.8%, –5.2% and –6.3% for the placebo, Q2W and QW arms, respectively (Q2Wversusplacebo, p=0.59; QWversusplacebo, p=0.63). The safety profile observed in the three treatment arms was generally similar, although serious adverse events were more common in the QW arm than in the other arms.The DRI11772 study failed to demonstrate benefit of SAR156597 in the treatment of IPF.
Impact of Surveillance Imaging Modality on Survival After Recurrence in Patients With Favorable-Histology Wilms Tumor: A Report From the Children’s Oncology Group
Authors: Mullen Elizabeth A. , Chi Yueh-Yun , Hibbitts Emily , Anderson James R. , Steacy Katarina J. , Geller James I. , Green Daniel M. , Khanna Geetika , Malogolowkin Marcio H. , Grundy Paul E. , Fernandez Conrad V. , Dome Jeffrey S. 
Published: October 2018

Purpose The use of computed tomography (CT) for routine surveillance to detect recurrence in patients with Wilms tumor (WT) has increased in recent years. The utility of CT, despite increased risk and cost, to improve outcome for these patients is unknown. We conducted a retrospective analysis with patients enrolled in the fifth National Wilms Tumor Study (NWTS-5) to determine if surveillance with CT correlates with improved overall survival (OS) after recurrence compared with chest x-ray (CXR) and abdominal ultrasound (US). Patients and Methods Overall, 281 patients with recurrent unilateral favorable-histology WT were reviewed to assess how WT recurrence was detected: sign/symptoms (SS), surveillance imaging (SI) with CT scan, or SI with CXR/US. Results The estimated 5-year OS rate after relapse was 67% (95% CI, 61% to 72%). Twenty-five percent of recurrences were detected with SS; 48.5%, with CXR/US; and 26.5%, with CT. Patients with SS had a 5-year OS rate of 59% (95% CI, 46% to 72%) compared with 70% (95% CI, 63% to 77%; P = .23) for those detected by SI. Recurrences detected by CT had a shorter median time from diagnosis to recurrence (0.60 years) compared with SS (0.91 years) or CXR/US (0.86 years; P = .003). For recurrences detected by SI, more tumor foci at relapse ( P < .001) and size of the largest focus greater than 2 cm ( P = .02) were associated with inferior OS. However, there was no difference in OS after relapse when recurrence was detected by CT versus CXR/US (5-year OS rate, 65% v 73%; P = .20). Conclusion In patients with favorable-histology WT, elimination of CT scans from surveillance programs is unlikely to compromise survival but would result in substantial reduction in radiation exposure and health care costs.
Regulation of actin-based apical structures on epithelial cells
Authors: Pelaseyed Thaher , Bretscher Anthony 
Published: October 2018

ABSTRACT
Cells of transporting epithelia are characterized by the presence of abundant F-actin-based microvilli on their apical surfaces. Likewise, auditory hair cells have highly reproducible rows of apical stereocilia (giant microvilli) that convert mechanical sound into an electrical signal. Analysis of mutations in deaf patients has highlighted the critical components of tip links between stereocilia, and related structures that contribute to the organization of microvilli on epithelial cells have been found. Ezrin/radixin/moesin (ERM) proteins, which are activated by phosphorylation, provide a critical link between the plasma membrane and underlying actin cytoskeleton in surface structures. Here, we outline recent insights into how microvilli and stereocilia are built, and the roles of tip links. Furthermore, we highlight how ezrin is locally regulated by phosphorylation, and that this is necessary to maintain polarity. Localized phosphorylation is achieved through an intricate coincidence detection mechanism that requires the membrane lipid phosphatidylinositol 4,5-bisphosphate [PI(4,5)P2] and the apically localized ezrin kinase, lymphocyte-oriented kinase (LOK, also known as STK10) or Ste20-like kinase (SLK). We also discuss how ezrin-binding scaffolding proteins regulate microvilli and how, despite these significant advances, it remains to be discovered how the cell polarity program ultimately interfaces with these processes.
Patient-centric implementation of an electronic medication management system at a tertiary hospital in Western Sydney
Authors: Gunja Naren , Dunlop Ian , Vaghasiya Milan , Kuan Kevin , Poon Simon 
Published: October 2018

BackgroundTraditional implementations of electronic medication management (EMM) systems have involved two common formats – a ‘big bang’ approach on the day of go-live, or a phased ward-by-ward approach over months.ObjectiveTo describe the patient-centric roll-out, a novel implementation model in converting from paper to EMM.MethodThis model iteratively converted a large tertiary teaching hospital to electronic from paper medication charts, commencing the roll-out in the emergency department (ED). The tenet of ‘one patient, one chart’ was maintained with new patients commenced on EMM, while existing inpatients were maintained on paper charts until their discharge. In the second week, all other intake points commenced patients on EMM, and in the third week, all remaining patients were manually converted to EMM. The implementation was assessed with training completion rates, staff satisfaction surveys, focus group interviews and incident logs.ResultsAt go-live, 79% of doctors, 68% of nurses and 90% of pharmacists were trained in the EMM system. The ED converted to electronic prescribing within 24 hours; by day 20, all patients were on EMM. Two hundred and thirty issues were logged, none critical, of which 22 were escalated. Of the 51,063 medications administered, there were 13 EMM-related clinical incidents including three double dosing errors, none of which led to an adverse event or death. Overall, 77% of staff surveyed were satisfied with the EMM implementation.ConclusionsThe patient-centric roll-out model represents an innovative and safe approach with a single medication chart reducing transcription and improved medication safety for the patient and the organisation.
An Outside View: Illustrations to the 1926 Subscribers’ Edition of The Seven Pillars of Wisdom
Authors: Notfors Emma 
Published: October 2018

The use of illustrations in mass-produced travel narratives had become commonplace, if not to say accepted practice, by the early Twentieth Century. Advancements in printing technologies allowed such books to be experienced by readers as sensory environments constituted by textual imagery and the successive display of vantage points and objects of the illustrations. Printing techniques and aspects of the physical book contribute to this visual ecology, resulting in a readerly construction of an aesthetic environment drawing on the collective output of author, printers and illustrators. It is as just such an aesthetic environment that this article will seek to understand the 1926 subscribers’ edition of The Seven Pillars of Wisdom: A Triumph, T.E. Lawrence’s account of his role in the Arab Revolt during the First World War. In order to analyse how these decisions work together to form an aesthetic whole, this article will consider its context in terms of the development of photography as the dominant illustrative mode for travel literature before moving on to an analysis of Lawrence’s own use of this medium before engaging with elements such as layout, typography, decoration and, finally, a series of illustrations produced by Eric Kennington.
Intrinsic and Extrinsic Value for English Learning: Mediation Effects of Self-Efficacy in Chinese EFL Context
Authors: Ma Lihong , Du Xiaofeng , Liu Jian 
Published: October 2018

Abstract
The present study examined how students’ intrinsic and extrinsic value promotes their foreign language proficiency via the mediation effect of self-efficacy beliefs. A total of 1,036 Chinese eighth graders answered an English proficiency test and questionnaires assessing motivational beliefs. Structural equation modelling results with bootstrapping procedures revealed that intrinsic value can directly and indirectly influence foreign language proficiency via partial mediation effect of self-efficacy while extrinsic value can only directly influence foreign language proficiency with a small magnitude. Moreover, there is no gender difference in the mediation model. Our findings suggested that intrinsic value can help students improve foreign language proficiency by improving their self-efficacy beliefs. The findings contribute to the documents of self-determination theory and hold substantive theoretical and practical implications for foreign language teachers.
A Case Study on Elementary CSL Learners’ Reading Anxiety
Authors: Sun Xiaohui , Luo Shaoqian 
Published: October 2018

Abstract
This paper reports a case study that explores elementary learners’ reading anxiety over Chinese as a second language (CSL). Two elementary CSL learners were chosen as research participants. Lived experience descriptions, think-aloud, retrospective interviews, field observations, and research journal writings were used to investigate the sources of elementary CSL learners’ reading anxiety and the ways employed to reduce their reading anxiety. The data were analyzed by Moustakas’ (1994) data analysis procedures, Creswell’s (2007) three steps, and Bogdon & Biklen’s (1992) data analysis methods. Results show that elementary CSL learners do have reading anxiety in their reading process and the sources of the anxiety include cross-linguistic differences between English and Chinese expressions, lack of previous knowledge, difficult and complex vocabulary, wrong guesses, and comprehension difficulties. Both participants tried to use strategies such as guessing, looking up words, understanding two character words based on the meaning of each character, skipping and keeping reading, and using previous knowledge to predict the rest of the text to reduce their reading anxiety. The present study provides both theoretical and pedagogical implications in the field of CSL reading learning and teaching.
Oral English Skills of Chinese University Students in Describing Their Native Culture
Authors: Lin Meixiao 
Published: October 2018

AbstractThis paper addresses the issue of Chinese students’ oral English skills in talking about Chinese culture from the perspective of conversation analysis. To examine their performance in this regard, group discussion data in the classroom were collected for analysis. Their oral skills in talking about Chinese New Year and Christmas, a Western festival, were analyzed and compared to determine their oral performance in describing their native culture. Comments by two native English speakers on the students’ performance are used to complement the conversation analysis. The results indicate that, compared with their performance regarding Christmas, the students were able to express a wider range of cultural connotations about Chinese New Year in English, but they used significantly fewer correct culturally-loaded words and phrases, and switched to Chinese much more frequently, suggesting unsatisfactory oral skills in describing Chinese culture.
Saussurian biolinguistics? Bouchard’s offline brain systems and Sign Theory of Language
Authors: Feeney Andrew 
Published: October 2018

Abstract
This article examines Bouchard’s (e.g. Bouchard, D. 2010. From neurons to signs. In A. D. M. Smith, M. Schouwstra, B. de Boer & K. Smith (ed.), Proceedings of the 8th International conference on the evolution of language, 42–49. Singapore: World Scientific; Bouchard, D. 2013. The nature and origin of language. Oxford: Oxford University Press; Bouchard, D. 2015. Brain readiness and the nature of language. Frontiers in Psychology 6.) discussion of the nature of language as ‘Saussurian Biolinguistics.’ A fundamental assumption of Bouchard, that of the existence of the Saussurian sign as a psychologically real entity in language, is disputed and an alternative understanding of the semiotic function of language is stressed. The consequences of Bouchard’s adoption of double interface signs for the relation of language to thought are also discussed and it is argued that such an approach leads inexorably to a form of linguistic relativity, and that positing a language independent ‘mentalese’ resolves this problem. The proposed model of language evolution, in which Bouchard is sceptical of protolanguage, is challenged, as are his claims regarding the properties of the language faculty. Bouchard presents a theory of the cognitive underpinning of language, ‘Offline Brain Systems,’ which is inadequate in accounting for the unique properties of human cognition. Instead, a more insightful and explanatorily comprehensive theory is presented here: dual-processing and the Representational Hypothesis.
FGFR3-related hypochondroplasia: longitudinal growth in 57 children with the p.Asn540Lys mutation
Authors: Arenas María Alejandra , del Pino Mariana , Fano Virginia 
Published: October 2018

Abstract

Background
Children with hypochondroplasia (HCH), who have FGFR3 mutations c.1620C>A or c.1620C>G (p.Asn540Lys) appear to have a more severe phenotype than those with HCH without these mutations. We describe the change in height, leg length and body proportions in a retrospective cohort of children with HCH related-p.Asn540Lys mutation and we compared them with Argentine population.

Methods
Anthropometric measurements were initially taken and followed up by the same observer, with standardized techniques. Sitting height/height and head circumference/height ratio were calculated as a body disproportion indicator. In order to make a comparison with the Argentine population height average, centiles of height, leg length and body proportions were estimated by the LMS method.

Results
The sample consisted of 57 HCH children (29 males and 28 females) between the ages of 0–18 years. The median (interquartile range) number of measurements per child was 8 (4.3, 13) for height, 7 (4, 12) for sitting height and 7.5 (4, 12.8) for head circumference. Leg length increased from 17 cm at birth to approximately 54 cm in adolescents, 25 cm shorter than the leg length in non-HCH populations. Sitting height increased from 39 cm at birth to 81 cm in adolescents, 7 cm below mean in non-HCH adolescents. Mean (range) adult height were 143.6 cm (131–154.5) and 130.8 cm (124–138) for males and females, respectively.

Conclusions
The disharmonic growth between the less affected trunk and the severely affected limbs determine body disproportion in HCH.
A Low-Carbohydrate Ketogenic Diet Reduces Body Mass Without Compromising Performance in Powerlifting and Olympic Weightlifting Athletes
Authors: Greene David A. , Varley Benjamin J. , Hartwig Timothy B. , Chapman Phillip , Rigney Michael 
Published: October 2018

Abstract
Greene, DA, Varley, BJ, Hartwig, TB, Chapman, P, and Rigney, M. A low-carbohydrate ketogenic diet reduces body mass without compromising performance in powerlifting and Olympic weightlifting athletes. J Strength Cond Res 32(12): 3382–3391, 2018—Weight class athletes use weight-making strategies to compete in specific weight categories with an optimum power-to-weight ratio. There is evidence that low carbohydrate diets might offer specific advantages for weight reduction without the negative impact on strength and power previously hypothesized to accompany carbohydrate restriction. Therefore, the purpose of this study was to determine whether a low-carbohydrate ketogenic diet (LCKD) could be used as a weight reduction strategy for athletes competing in the weight class sports of powerlifting and Olympic weightlifting. Fourteen intermediate to elite competitive lifting athletes (age 34 ± 10.5, n = 5 female) consumed an ad libitum usual diet (UD) (>250 g daily intake of carbohydrates) and an ad libitum LCKD (≤50 g or ≤10% daily intake of carbohydrates) in random order, each for 3 months in a crossover design. Lifting performance, body composition, resting metabolic rate, blood glucose, and blood electrolytes were measured at baseline, 3 months, and 6 months. The LCKD phase resulted in significantly lower body mass (−3.26 kg, p = 0.038) and lean mass (−2.26 kg, p = 0.016) compared with the UD phase. Lean mass losses were not reflected in lifting performances that were not different between dietary phases. No other differences in primary or secondary outcome measures were found between dietary phases. Weight class athletes consuming an ad libitum LCKD decreased body mass and achieved lifting performances that were comparable with their UD. Coaches and athletes should consider using an LCKD to achieve targeted weight reduction goals for weight class sports.
Versiones y aversiones al paisaje andino (Siete últimos acercamientos desde la arquitectura)
Authors: Falconi José Luis , Infante Javiera 
Published: October 2018

Referencias:Canziani, José. (2009). Ciudad y territorio en los Andes. Lima: Fondo Editorial Pontificia Universidad Católica del Perú.Castellanos Schnitter, Patricia. (2003). Sert y Wiener en Colombia. La vivienda social en la aplicación del urbanismo moderno. Scripta Nova, VII(146). Recuperado de http://www.ub.edu/geocrit/sn/sn-146(035).htmClaghorn, Joseph; Orsini, Francesco Maria; Echeverri Restrepo, Carlos Alejandro y Werthmann, Christian. (2015). Rehabitar la Montaña: Strategies and processes for sustainable communities in the mountainous periphery of Medellín. Urbe. Revista Brasileira de Gestão Urbana (Brazilian Journal of Urban Management). Recuperado de http://www.scielo.br/pdf/urbe/2015nahead/2175-3369-urbe-2175-3369008001SE03.pdfColegio de Arquitectos del Perú. (2010). Una Aproximación a la obra del arquitecto Ernesto Gastelumendi Velarde. Lima: Autor.Crousse, Jean Pierre. (2016). El paisaje peruano. Lima: Fondo Editorial Pontificia Universidad Católica del Perú.De Soto, Hernando. (1992). El Otro Sendero. Buenos Aires: Editorial Sudamericana.Gorelik, Adrián. (2001). La grilla y el parque: espacio público y cultura urbana en Buenos Aires, 1887-1936. Buenos Aires: Universidad Nacional de Quilmes.Jackson, John Brinckerhoff. (2012). La necesidad de ruinas y otros ensayos (Trad. por Romy Hecht y Danilo Martic). Santiago: Ediciones ARQ.Melo, Jorge Orlando. (2017). Historia mínima de Colombia. Ciudad de México: Colegio de México.Ross, Patricio; Pérez de Arce, Mario y Viveros, Marta. (1982). Santiago: espacio urbano y paisaje. Santiago de Chile: Ediciones Universidad Católica de Chile.Serpar. (2014). Lomas de Lima: futuros parques de la ciudad. Lima: Autor.Von Humboldt, Alexander y Bonpland, Aimé. (1807). Ideen zu einer Geographie der Pflanzen usf. Tübingen: Bey F. G. Cotta.
Diabetes mellitus talaján kialakult osteomyelitis kezelése
Authors: Szabó Viktor Zoltán , Lázár György , Borda Béla , Lengyel Csaba , Várkonyi Tamás , Hódi Zoltán , Borda Bernadett 
Published: October 2018

Abstract: The authors summarize the medical history of a patient with impaired healing of a wound in the sole of foot. The 63-year-old male patient had a second-degree burn in the sole of the left foot as he stepped on the hot concrete after taking off his slipper. On admission to our department, local wound management had already been started, his wound showed no healing tendency. Bilateral X-ray was performed of his left leg, osteomyelitis was not confirmed, soft tissue drainage was applied, and bacterial culture from the wound confirmed methicillin-resistant Staphylococcus aureus infection. After soaking the leg in water, phlegmon developed on the dorsal part of the foot and the patient had septic fever. X-ray was repeated, and osteomyelitis was confirmed. Enucleation of the hallux of the left foot and metatarsal resection were performed. Wound dressing was exchanged and wound toilette was applied daily, insulin therapy was modified after consultation with a diabetologist. 7 months after the surgery, the wound was completely healed, carbohydrate metabolism of the patient was controlled. Our case draws attention to the importance of informing the patients of potential complications – in this case of the diabetic foot and its proper care. Treatment of ulcer of the lower leg requires multidisciplinary care, which means that the diabetologist and the surgeon has to cooperate in the care of these patients, carbohydrate metabolism should be balanced and regular wound care is necessary. Orv Hetil. 2018; 159(42): 1727–1730.