bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evolution of agriculture finance in India: a historical perspective
Authors: Bharti Nisha 
Published: May 2018

Purpose
Lack of access to finance is one of the major contributing to low profitability in agriculture. Various policy interventions were performed for promoting access to finance. However, access to finance always remained one of the biggest challenges to Indian policymakers. The purpose of this paper is to explore the policy interventions in the areas of agriculture finance.

Design/methodology/approach
This paper makes an attempt to explore the relation of earlier policy initiatives with the current microfinance industry as well. The data for the paper are collected from Reserve Bank of India Archive Museum at Pune. This Museum is having huge collection of archives of policy documents of the Indian financial sector and is one of its kinds in India.

Findings
The study concludes that many of the interventions of today were earlier experimented or proposed in the past but, due to some or the other reason those, interventions were not successful. The study concludes that if those interventions had been implemented that time, it would have taken India in one of the tops in the list of financial inclusion.

Originality/value
This paper is a unique in its feature as it has tried to link the evolution of agriculture finance and the microfinance industry of India as microfinance is an integral part of agricultural finance in India.
Locus of legitimacy and startup resource acquisition strategies
Authors: Yang Yi Ling , Lee Sungho , Kim Sahangsoon 
Published: May 2018

PurposeTheoretically, the paper aims to provide locus of legitimacy as a framework to not only introduce a multidimensional perspective on legitimacy but also expand the understanding about resource acquisition strategies of social enterprises. Empirically, the authors test the theoretical predictions by using cases from South Korea and Taiwan. Practically, the authors intend to assist chief executive officers (CEOs) of social enterprises in their effort to secure valuable resources and provide policy implications so that both South Korea and Taiwan learn from each other.Design/methodology/approachThe authors use case methods to find evidence of the proposed theoretical framework. The initial search for target companies showed that social enterprises in South Korea and Taiwan were ideal samples. In-person, email and phone interviews were conducted on CEOs, and archival data on institutional environments and various aspects of social enterprises were collected. Collected data were analyzed using the locus of legitimacy framework to find out how different emphasis on locus of legitimacy impacted critical decisions of social enterprise, such as human, financial and network resources.FindingsAs predicted in the locus of the legitimacy framework, the analyses confirmed that locus of legitimacy did explain critical decisions of social enterprises in South Korea and Taiwan. First, significant institutional forces existed, shaping social enterprises behavior. For example, Taiwanese Jinu showed that greater emphasis was given to internal legitimacy, while South Korean Sohwa was higher in external locus of legitimacy. Such differences systematically impacted choices made on resource acquisition strategies. Jinu showed a greater similarity to those of for-profit companies, aligning key decisions of resource acquisition strategies to achieve financial viability as a top priority. However, Sohwa, though financial performance was still important, put more emphasis on meeting institutional demands from South Korean Government.Originality/valueThis study is one of early studies that attempts to understand the structure of legitimacy faced by social enterprises. The authors argue that organizations can play a more proactive role in securing legitimacy. The authors believe that locus of legitimacy framework complements the existing understanding about legitimacy in institutional theory. By introducing a multidimensional perspective about legitimacy, the authors add additional explanations about how firms exposed to different institutional forces can have diverse alternatives in resource acquisition strategies.
Japanese government venture capital: what should we know?
Authors: Kirihata Tetsuya 
Published: May 2018

PurposeThe purpose of this paper is to discuss the implication of Japanese government venture capital (VC) policies for future research and to provide basis for policymakers and practitioners.Design/methodology/approachThis is an academic literature review of available peer-reviewed publications on government VC policies. This paper discusses and analyses the current state and issues of the Japanese government VC policies regarding three research questions: What do Japanese government VCs do? Do they contribute to their portfolios? and Do they contribute to the development of VC market?FindingsThere are mainly two findings in this paper: It is effective to establish a complementary relationship with private VCs for Japanese government VCs to contribute to their portfolios; Japanese government should simultaneously continue to make and review policies for the VC market, the stock market, the entrepreneur sector and the environment surrounding them by its strategic long-term commitment to contribute to the development of VC market and new technology-based firms in Japan.Originality/valueAs there are only a few studies on recently strengthened Japanese government VC policies, this paper provides an in-depth discussion on these Japanese VC policies, which can be used for future research and as a valuable resource for policymakers and practitioners.
Examining the effects of interorganizational learning on performance: a meta-analysis
Authors: Rajala Anni 
Published: May 2018

Purpose
Relationship learning is viewed as an important factor in enhancing competitiveness and an important determinant of profitability in relationships. Prior studies have acknowledged the positive effects of interorganizational learning on performance, but the performance measures applied have varied. The purpose of this study is to examine the relationship between interorganizational learning and different types of performance. The paper also goes beyond direct effects by investigating the moderating effects of different research designs.

Design/methodology/approach
This paper applies a meta-analytic approach to systematically analyze 21 independent studies (N = 4,618) to reveal the relationship between interorganizational learning and performance.

Findings
The findings indicate that interorganizational learning is an important predictor of performance, and that the effects of interorganizational learning on performance differ in magnitude under different research conditions.

Research limitations/implications
The paper focuses on interorganizational learning, and during the data collection, some related topics were excluded from the data search to retain the focus on learning.

Practical implications
The study evinces the breadth of the field of interorganizational learning and how different research designs affect research results. Moreover, this meta-analysis indicates the need for greater clarity when defining the concepts used in studies and for definitions of the concepts applied in the field of interorganizational learning to be unified.

Originality/value
This study is the first to meta-analytically synthesize literature on interorganizational learning. It also illuminates new perspectives for future studies within this field.
Factors affecting operation and maintenance cost of hotels
Authors: Ihsan Bakhter , Alshibani Adel 
Published: May 2018

Purpose
The purpose of this paper is to identify, assess, rank, and compare the most influencing factors in three-, four-, and five-star hotels in the Eastern Province in Saudi Arabia.

Design/methodology/approach
A combination of literature and interviewing of ten local experts have resulted in the identification of 46 factors. Through a web-based questionnaire survey, the identified factors were ranked. A total of 23 responses were gathered from the full population of the 47 hotels (14 five-star, 15 four-star and 18 three-star hotels) in the Eastern Province of Saudi Arabia. A reliable overall response rate of 50 percent was achieved.

Findings
The most important factors affecting the operating and maintenance cost of five-star hotels are “climatic conditions” followed by “availability of the materials,” “annual energy consumption rate,” and “efficient energy consuming equipment.” Regarding four-star hotels, those factors are “star rating of the hotel” followed by “customer satisfaction,” “occupancy rate,” and “efficient energy consuming equipment.” Finally, the top-ranked factors for three-star hotels are “climatic conditions” followed by “floor area,” “glass and non-glass façade,” and “occupancy rate.”

Research limitations/implications
The most important factors affecting the operating and maintenance cost of five-star hotels are “climatic conditions” followed by “availability of the materials,” “annual energy consumption rate,” and “efficient energy consuming equipment.” Regarding four-star hotels, those factors are “star rating of the hotel” chased by “customer satisfaction,” “occupancy rate,” and “efficient energy consuming equipment.” Finally, the top-ranked factors for three-star hotels are “climatic conditions” followed by “floor area,” “glass and non-glass façade,” and “occupancy rate.” The shared concern point between the respondents of all three groups of hotels is relevant to the energy department, which keeps the facility running.

Originality/value
This paper is original in the sense that the areas of knowledge and practice covered in the identified factors were distributed and not available in one source. The factors are derived from personal interviews with the selected operation and maintenance/engineering managers of all three classes of hotels, and from the relevant literature.
Bart's syndrome in a family affected three consecutive generations with mutation c.6007G>A in COL7A1
Authors: Chen Zhiming , Bu Wenbo , Feng Suying , Wang Hongsheng 
Published: May 2018

AbstractBart's syndrome (BS), characterized by aplasia cutis congenita (ACC, also called congenital localized absence of skin) and epidermolysis bullosa (EB), is diagnosed clinically based on the disorder's unique signs and symptoms. We report the case of a family, three members of which presented with ACC at birth and one had blisters on the mucous membranes. The patient was treated conservatively with topical antibacterial ointment and wet gauze dressing. Periodic follow up showed complete healing with minimal scarring. Whole‐exome sequencing confirmed a heterozygous mutation (rs121912832, c.6007G>A, p.G2003R) within exon 73 of COL7A1, which was confirmed by the only two genetic studies available, is suggested to be the molecular basis for the family's disorder. As a consequence, we suggest that c.6007G>A within exon 73 of COL7A1 could be a specific mutation for BS in antenatal screening. It is of great value to extend the genetic test among affected families and uncover the mechanism behind this unique syndrome.
S‐wave kinematics in acoustic transversely isotropic media with a vertical symmetry axis
Authors: Jin Song , Stovas Alexey 
Published: May 2018

ABSTRACTAcoustic transversely isotropic models are widely used in seismic exploration for P‐wave processing and analysis. In isotropic acoustic media only P‐wave can propagate, while in an acoustic transversely isotropic medium both P and S waves propagate. In this paper, we focus on kinematic properties of S‐wave in acoustic transversely isotropic media. We define new parameters better suited for S‐wave kinematics analysis. We also establish the travel time and relative geometrical spreading equations and analyse their properties. To illustrate the behaviour of the S‐wave in multi‐layered acoustic transversely isotropic media, we define the Dix‐type equations that are different from the ones widely used for the P‐wave propagation.
Simultaneous Determination of 13 Anticoagulant Rodenticidesin Human Blood by Liquid Chromatography–Tandem Mass Spectrometry and its Application in Three Poisoning Cases
Authors: Qiao Zheng , Xiang Ping , Shen Baohua , Shen Min , Yan Hui 
Published: May 2018

AbstractAnticoagulant rodenticides are widely used for rodent control around the world. A rapid and sensitive method was developed and validated for the simultaneous determination of 13 anticoagulant rodenticides (coumafuryl, pindone, valone, warfarin, coumatetralyl, coumachlor, diphacinone, dicumarol, chlorophacinone, bromadiolone, difenacoum, flocoumafen, and brodifacoum) in human blood by liquid chromatography–tandem mass spectrometry. After liquid–liquid extraction, the anticoagulant rodenticides were separated on an Eclipse Plus C18 column. Linearities were observed for each analyte in blood ranging from 0.5 to 50 ng/mL, with correlation coefficients over 0.99. The limits of detection ranged from 0.01 to 0.2 ng/mL, and the limits of quantification were 0.5 ng/mL for all analytes. The intraday and interday precisions were <15%, and accuracies ranged from 80.3% to 111.0%. This validated method with high sensitivity has been applied in three anticoagulant rodenticide poisoning cases and has been used successfully in monitoring blood concentrations for months.
Prevention of post‐sphincterotomy bleeding by proton pump inhibitor: A randomized controlled trial
Authors: Leung Wai K , But David YK , Wong Siu‐Yin , Tong Teresa SM , Liu Kevin SH , Cheung Ka‐Shing , Tsang Simon HY , Chok Kenneth SH , Poon Ronnie TP , Hung Ivan FN 
Published: May 2018

OBJECTIVEPost‐endoscopic sphincterotomy (EST) bleeding is one of the most frequent complications of endoscopic retrograde cholangiopancreatography (ERCP). Although the use of proton pump inhibitors (PPIs) reduces the risk of peptic ulcer bleeding, their role in preventing EST bleeding has not been evaluated. This study aimed to assess the use of pre‐emptive PPIs in patients undergoing EST.METHODSThis was an investigator‐initiated, open‐label, randomized study. Consecutive patients scheduled to undergo ERCP and EST were enrolled after excluding those who had previous EST or used acid‐suppression agents. Eligible patients were randomized to receive either PPI or standard care. The PPI group received intravenous esomeprazole 4 h before the EST and then every 12 h for 1 day, followed by high‐dose oral esomeprazole for 10 days. All patients were followed up for 30 days. The primary outcome was the proportion of patients with combined immediate and delayed overt post‐EST bleeding.RESULTSAltogether 125 patients (60 in the PPI arm and 65 in the standard care arm) who had undergone EST were analyzed. Immediate bleeding was noted in nine (15.0%) patients in the PPI group and four (6.2%) in the standard care group (P = 0.14). Overt delayed post‐EST bleeding was seen in two (3.3%) and five (7.7%) patients in PPI and standard care arms, respectively (P = 0.44). There were no significant differences in other outcomes, including a decrease in hemoglobin of >20 g/L, the need for blood transfusion, length of hospital stay and 30‐day mortality.CONCLUSIONPre‐emptive PPI did not reduce the risk of post‐EST bleeding.
Hydroxychloroquine retinal toxicity in two patients with dermatological conditions
Authors: Kowalski Tanya , Baker Christopher , Mack Heather G 
Published: May 2018

AbstractTwo patients with dermatological conditions developed retinal toxicity after treatment with hydroxychloroquine that exceeded dosing recommendations. There is no treatment for hydroxychloroquine retinal toxicity and associated visual loss, so appropriate monitoring is imperative. All members of a patient's multidisciplinary team should be aware of the ocular risks of hydroxychloroquine, the importance of dosing within recommended guidelines and appropriate monitoring in reducing the risk of visual loss.
Multifaceted Pharmacist‐led Interventions in the Hospital Setting: A Systematic Review
Authors: Skjøt‐Arkil Helene , Lundby Carina , Kjeldsen Lene Juel , Skovgårds Diana Mark , Almarsdóttir Anna Birna , Kjølhede Tue , Duedahl Tina Hoff , Pottegård Anton , Graabæk Trine 
Published: May 2018

AbstractClinical pharmacy services often comprise complex interventions. In this MiniReview, we conducted a systematic review aiming to evaluate the impact of multifaceted pharmacist‐led interventions in a hospital setting. We searched MEDLINE, Embase, Cochrane Library and CINAHL for peer‐reviewed articles published from 2006 to 1 March 2018. Controlled trials concerning hospitalized patients in any setting receiving patient‐related multifaceted pharmacist‐led interventions were considered. All types of outcome were accepted. Inclusion and data extraction were performed. Study characteristics were collected, and risk of bias assessment was conducted utilizing the Cochrane Risk of Bias tools. All stages were conducted by at least two independent reviewers. The review was registered in PROSPERO (CRD42017075808). A total of 11,896 publications were identified, and 28 publications were included. Of these, 17 were conducted in Europe. Six of the included publications were multi‐centre studies, and 16 were randomized trials. Usual care was the comparator. Significant results on quality of medication use were reported as positive in eleven studies (n = 18; 61%) and negative in one (n = 18, 6%). Hospital visits were reduced significantly in seven studies (n = 16; 44%). Four studies (n = 12; 33%) reported a positive significant effect on either length of stay or time to revisit, and one study reported a negative effect (n = 12; 6%). All studies investigating mortality (n = 6), patient‐reported outcome (n = 7) and cost‐effectiveness (n = 1) showed no significant results. This MiniReview indicates that multifaceted pharmacist‐led interventions in a hospital setting may improve the quality of medication use and reduce hospital visits and length of stay, while no effect was seen on mortality, patient‐reported outcome and cost‐effectiveness.
LW106, a novel indoleamine 2,3‐dioxygenase 1 inhibitor, suppresses tumour progression by limiting stroma‐immune crosstalk and cancer stem cell enrichment in tumour micro‐environment
Authors: Fu Rong , Zhang Yi‐Wei , Li Hong‐Mei , Lv Wen‐Cong , Zhao Li , Guo Qing‐Long , Lu Tao , Weiss Stephen J , Li Zhi‐Yu , Wu Zhao‐Qiu 
Published: May 2018

Background and PurposeIndoleamine 2,3‐dioxygenase 1 (IDO1) is emerging as an important new therapeutic target for treatment of malignant tumours characterized by dysregulated tryptophan metabolism. However, the antitumour efficacy of existing small‐molecule inhibitors of IDO1 is still unsatisfactory and the underlying mechanism remains largely undefined. Hence, we discovered a novel potent small‐molecule inhibitor of IDO1, LW106, and studied its antitumour effects and the underlying mechanisms in two tumour models.Experimental ApproachC57BL6 mice, athymic nude mice or Ido1−/− mice were inoculated with IDO1‐expressing and ‐nonexpressing tumour cells and treated with vehicle, epacadostat or increasing doses of LW106. Xenografted tumours, plasma, spleens and other vital organs were harvested and subjected to kynurenine/tryptophan measurement and flow cytometric, histological and immunohistochemical analyses.Key ResultsLW106 dose‐dependently inhibited the outgrowth of xenografted tumours that were inoculated in C57BL6 mice but not nude mice or Ido1−/− mice, showing a stronger antitumour efficacy than epacadostat, an existing IDO1 inhibitor. LW106 substantially elevated intratumoural infiltration of proliferative Teff cells, while reducing recruitment of proliferative Treg cells and non‐haematopoietic stromal cells such as endothelial cells and cancer‐associated fibroblasts. LW106 treatment resulted in a reduced subpopulation of cancer stem cells (CSCs) in xenografted tumours in which fewer proliferative/invasive tumour cells and more apoptotic tumour cells were observed.Conclusions and ImplicationsLW106 inhibits tumour outgrowth by limiting stroma‐immune crosstalk and CSC enrichment in the tumour micro‐environment. LW106 has potential as a immunotherapeutic agent for use in combination with immune checkpoint inhibitors and (or) chemotherapeutic drugs for cancer treatment.
Total factor productivity spillovers from trade reforms in India
Authors: Bos Marijke J. D. , Vannoorenberghe Gonzague 
Published: May 2018

AbstractIt is often argued that the positive effects of policies or institutional reforms on the productivity of firms are amplified by positive spillovers to other firms. In this paper, we use a comprehensive dataset of Indian manufacturing firms and employ spatial econometric techniques to estimate the strength of inter‐firm total factor productivity (TFP) spillovers within India following trade reforms. We use externally imposed tariff reductions as an exogenous source of variation in TFP (following Topalova and Khandelwal) and test for spillovers arising from observation, labour mobility and intermediate input use. We find no evidence of TFP spillovers between Indian manufacturing firms after trade liberalization on average. However, initially productive firms seem to benefit from TFP increases in other highly productive firms located in their vicinity.RésuméEffets de débordement via la productivité total des facteurs des réformes commerciales en Inde. On suggère souvent que les effets positifs des politiques ou réformes institutionnelles sur la productivité des firmes sont amplifiés par les effets positifs de débordement sur d’autres firmes. Dans ce mémoire, on utilise une base de données compréhensive de firmes manufacturières indiennes et des techniques économétriques spatiales pour calibrer la force de cet effet de débordement entre firmes via la productivité totale des facteurs (PTF) à l’intérieur de l’Inde à la suite de réformes commerciales. On utilise des réductions de tarifs imposées de l’extérieur comme source exogène de variation dans la PTF (suivant en cela Topalova et Khandelwal 2011) et on calibre les effets de débordement par observation, mobilité du travail, et utilisation d’inputs intermédiaires. On ne détecte aucun effet de débordement de la PTF entre les firmes manufacturières après la libéralisation du commerce en moyenne. Cependant les firmes initialement productives semblent bénéficier de l’accroissement de la PTF d’autres firmes productives dans les environs.