bluuebunny/crossref_metadata_2025_split huggingface dataset:
BeGuideWell: A prospective cross-sectional study analysing the awareness and opinions of nursing students in Poland on the usefulness of European Society of Cardiology guidelines in post-graduate education programme
Authors: Uchmanowicz Izabella , Wleklik Marta , Hill Loreena , Lisiak Magdalena , Chudiak Anna , Lomper Katarzyna , Lambrinou Ekaterini , Jennings Catriona , Fitzsimons Donna 
Published: May 2019

Background: The role of clinical guidelines is to provide patients with the best quality, evidence-based care. Nurses are actively involved in the development of the European Society of Cardiology guidelines. A number of the guidelines include specific recommendations relating to nursing duties and, hence, nurses require necessary knowledge and skills for their implementation. Inclusion of the guidelines in the curricula for university nursing programmes could facilitate their implementation to everyday practice. Aim: The purpose of this study was to determine the awareness and opinions of Polish nursing students who participated in a guideline-based Master of Science education programme about the usefulness of the European Society of Cardiology guidelines. Methods: A prospective and cross-sectional research design was used and Strengthening the Reporting of Observational studies in Epidemiology guidelines were followed. A total of 188 nursing students (mean age 31.18±10.41 years) who met the inclusion criteria were invited to complete the BeGuideWell survey. This instrument included 16 questions: five on participants’ demographics and 11 addressing the issues associated with the European Society of Cardiology guidelines. The Yates chi-squared test or Fisher exact test were used for statistical analysis. Results: The majority of students had become familiar with the diagnostics and treatment of acute and chronic heart failure. Nearly half of the students documented that they had never heard of the European Society of Cardiology guidelines before starting the Master of Science programme. Most students found the European Society of Cardiology guidelines helpful for their university education. Most respondents stated that the guidelines were useful in their everyday practice and believed that they contributed to better quality of patient care. Conclusions: Students can become more familiar with the European Society of Cardiology guidelines during the course of their post-graduate education, preparing them to implement the European Society of Cardiology guidelines in their everyday practice.
Different microbiological profiles between hip and knee prosthetic joint infections
Authors: Tsai Yifang , Chang Chih-Hsiang , Lin Yu-Chih , Lee Sheng-Hsun , Hsieh Pang-Hsin , Chang Yuhan 
Published: May 2019

Purpose: The study aims to analyze the demographics and microbiological profiles of hip and knee prosthetic joint infection (PJI) and to compare the microbiological differences between hip and knee PJI. Methods: We performed a retrospective study of all PJI cases between January 2006 and December 2014 at a referral medical center in Taiwan. Results: A total of 294 PJI cases were collected: 159 were identified as hip PJI and 135 as knee PJI. The most common causative pathogen was Staphylococcus aureus (78 cases, 27%), followed by coagulase-negative staphylococci (CoNS, 42 cases, 14%). Methicillin-resistant staphylococci (MRS) accounted for 21% of all PJI cases. Fungus and mycobacterium were only involved in 12 cases (4.1%) of all PJI cases. Polymicrobial pathogens, anaerobes, and enteric gram-negative bacilli (GNB) were more likely to occur in hip joint prostheses than in knee joint prostheses (22 vs. 6 cases, p = 0.006; 11 vs. 0 cases; p = 0.002; 20 vs. 6 cases; p = 0.014, respectively). Conclusion: The prevalence of polymicrobial pathogens, anaerobes, and enteric GNB was higher in the prosthetic hip infection than in the prosthetic knee infection. The high prevalence of MRS, including Methicillin-resistant (MR) S. aureus and MR-CoNS in PJI, may warrant the need for empiric antibiotic therapy with broader coverage while pending the culture result of PJI. Although fungal and mycobacterial PJI cases are rare, the incidence of these infections is relatively high in Taiwan. Fungus and mycobacterium should also be taken into consideration whenever a persistent PJI case is encountered.
A prospective randomized study comparing navigation versus conventional total knee arthroplasty
Authors: Selvanayagam Rajkumar , Kumar Vijay , Malhotra Rajesh , Srivastava Deep Narayan , Digge Vijay Kumar 
Published: May 2019

Background: Navigation is associated with improved accuracy in alignment. However, its influence on clinical outcome is inconclusive. The aim of this study was to compare the component alignment and functional outcome in patients undergoing navigation-assisted and conventional total knee replacement (TKR). Materials and method: A prospective randomized study consisting of two groups (group A and group B) was carried out. Group A consisted of patients undergoing TKR using conventional jig-based method, whereas group B consisted of patients undergoing TKR using computer navigation-assisted method. We measured and compared the coronal and sagittal plane alignment in X-ray and rotational alignment in computed tomography scan between both groups. Functional outcome was analysed using Knee Society Score (KSS) and Western Ontario and McMaster University scale (WOMAC) score. Results: A total of 50 patients were randomized into two groups A and B each with 25 patients. Navigation was associated with more accuracy in mechanical axis alignment ( p = 0.011) and femoral component rotation ( p = 0.033). The mean follow-up was 4.6 years (range 48–62 months). There was no statistically significant difference between the groups with respect to KSS and WOMAC score at the minimum follow-up of 4 years. Conclusion: We concluded that even though navigation-assisted system is associated with better accuracy, there was no difference in clinical outcome at an average follow-up of 4.6 years.
Characteristics of frontal plane lower limb movement during walking in patients with knee osteoarthritis of varying severity
Authors: Fukaya Takashi , Mutsuzaki Hirotaka , Nakano Wataru , Mori Koichi 
Published: May 2019

Purpose: This study aimed to investigate the effect of knee joint structural destruction on frontal plane hip and ankle joint kinematics and kinetics during the stance phase of walking in patients with differing severities of knee osteoarthritis (KOA). Methods: An early KOA group consisted of eight subjects with bilateral knee Kellgren–Lawrence (KL) scale scores of 1 or 2. An established KOA group comprised nine subjects (18 knees) with KL scores of 3 or 4. To measure walking, the data were obtained using the motion analysis system and force plates. From the ground reaction force data, the stance phase of gait was divided into five periods. Results: In the established KOA group, the hip joint was significantly abducted, and the knee joint had significantly greater varus positioning during the stance phase. In addition, in the established KOA group, a significant knee abductor moment was observed during the stance phase. In contrast, in the early KOA group, the ankle joint showed a significant inversion moment during the stance phase, but in the established KOA group, the ankle joint moment was very small. Conclusions: The structural destruction of the knee joint in the frontal plane in patients with the established KOA changes the movement of the hip and the moment of the ankle.
Association of anemia with sensorineural hearing loss: a systematic review and meta-analysis
Authors: Mohammed Shimel Hussien , Shab-Bidar Sakineh , Abuzerr Samer , Habtewold Tesfa Dejenie , Alizadeh Shahab , Djafarian Kurosh 
Published: May 2019

Abstract
Objective
Evidence shows that anemic individuals are at a higher risk of hearing loss. However, there is no systematic review and meta-analysis study. Thus, we aimed to meta-analyze the existing evidence on the association of iron deficiency anemia (IDA) with sensorineural hearing loss (SNHL). We searched PubMed, MEDLINE, Embase, Scopus, and Google Scholar from inception through October 30, 2017, for studies done on the association of the IDA with SNHL. Pooled odds ratio (OR) was calculated by random effect meta-analysis method. Heterogeneity was assessed by I2 metrics.

Result
Four studies, covering a total of 344,080 adults and children, were included. The odds of SNHL was higher by 55% in individuals with IDA, compared with individuals without IDA (OR = 1.55, 95% CI 1.17–2.06; P = 0.03). The age-specific ORs were 1.36 (95% CI 1.15–1.61; P = 0.27) and 3.67 (95% CI 1.72–7.84) for adults and children, respectively. IDA may be a contributing factor to hearing loss. Further studies are warranted, including whether IDA treatment reduces the risk of hearing loss. Meanwhile, hearing loss screening in anemic individuals, or vice versa, may represent an important consideration.
PROSPERO registration CRD42017082108
Improving Long-Term Outcomes of Youth With Lipid Abnormalities—Expanding the Role of Pediatric Endocrinologists
Authors: Ashraf Ambika P , Kohn Brenda , Wilson Don P 
Published: May 2019

Abstract

Context
There is a disturbingly high prevalence of dyslipidemia in youth. Although pediatric endocrinologists are aware of the substantial cardiovascular (CV) risk associated with monogenic disorders of lipid and lipoprotein metabolism, relatively few recognize the CV disease (CVD)-related morbidity and premature mortality incurred by common endocrine disorders associated with dyslipidemia, such as diabetes mellitus, growth hormone deficiency, congenital adrenal hyperplasia, and hypopituitarism.

Objective
In this article, we discuss the expanding role of pediatric endocrinologists in CV health and risk prevention.

Design
We reviewed available literature and summarized discussions with opinion leaders in pediatric endocrinology to accomplish the following: (i) provide an overview of this timely topic; (ii) identify opportunities for targeted education; and (iii) discuss ways of expanding clinical services to improve outcomes.

Results
In addition to well-known genetic disorders of lipid and lipoprotein metabolism, youth with common endocrine disorders, including type 1 and type 2 diabetes, would benefit from cholesterol screening and in some, early intervention, including use of lipid-lowering medications. Despite the growing need, the location and extent of services available to youth with dyslipidemia and the availability of providers with experience in treatment of dyslipidemia are largely unknown but likely inadequate to provide accessible, timely, and cost-effective intervention.

Conclusion
With a new awareness of opportunities to prevent premature CVD in youth, including those with common endocrine disorders and CVD-related events during adulthood, there is an urgent need for additional clinical services and targeted education of current as well as future pediatric endocrinologists.
Placental Sonic Hedgehog Pathway Regulates Fetal Growth via the IGF Axis in Preeclampsia
Authors: Takai Hiroshi , Kondoh Eiji , Mogami Haruta , Kawasaki Kaoru , Chigusa Yoshitsugu , Sato Mai , Kawamura Yosuke , Murakami Ryusuke , Matsumura Noriomi , Konishi Ikuo , Mandai Masaki 
Published: May 2019

Abstract

Context
Placental dysfunction is the underlying cause of common major disorders of pregnancy, such as fetal growth restriction and preeclampsia. However, the mechanisms of placental dysfunction are not entirely elucidated. We previously reported 10 reliable preeclampsia pathways based on multiple microarray data sets, among which was the sonic hedgehog (SHH) pathway. In this study, we describe the significant role of SHH signaling involved in placental development and fetal growth.

Design
The placental expression levels of surrogate markers of the SHH pathway, patched homolog 1 (PTCH1) and glioma-associated oncogene homolog (GLI) 2, were evaluated using quantitative real-time PCR, western blot analysis, and immunohistochemistry. We investigated the underlying mechanisms of the SHH pathway in trophoblast syncytialization, a critical process for placental development and maturation, using primary cytotrophoblasts. Moreover, the potential roles of placental SHH signaling in the regulation of the IGF axis were explored by pathway analysis of microarray data. Finally, the influence of SHH signaling on fetal growth was examined by placental administration of cyclopamine, an SHH pathway inhibitor, to pregnant mice.

Results
The SHH pathway was downregulated in preeclampsia placentas, and its activation was highly correlated with birth weight. Trophoblast syncytialization was modulated by noncanonical SHH–adenylate cyclase (ADCY) signaling rather than canonical SHH–GLI signaling. The IGF1 receptor pathway was regulated by both noncanonical SHH–ADCY signaling and canonical SHH–GLI signaling. Inhibition of placental SHH signaling significantly reduced fetal weight in mice.

Conclusion
Placental development and fetal growth were regulated through the SHH pathway via the IGF axis.
Exploring the Perspectives of Parents and Siblings Toward Future Planning for Individuals With Intellectual and Developmental Disabilities
Authors: Lee Chung eun , Burke Meghan M. , Stelter Claire R. 
Published: May 2019

Abstract
Parents often provide the bulk of caregiving supports for their adult offspring with intellectual and developmental disabilities (IDD). Given the longer lives of people with IDD, however, such caregiving roles may transition to siblings. Thus, it is critical to conduct future planning among family members (e.g., parents, siblings) to prepare for the transition of caregiving roles. To this end, we interviewed 10 parent-sibling dyads (N = 20) of people with IDD about long-term planning. Both parents and siblings reported family-related and systemic barriers to developing future plans. Siblings (unlike parents) reported wanting more communication among family members about planning. Implications for future research and practice are discussed.
Governance In Clusters: An Analysis From the Perspective of System Dynamics
Authors: Salume Paula karina , Guimaraes Liliane Oliveira , Rantisi Norma M. 
Published: May 2019

Objective: The present study analyzes how the relation between the contextual, structural and instrumental dimensions of governance influence the evolution of productive agglomerations in the segment of gems and jewel. Method: Qualitative-descriptive research was, therefore, undertaken, applying the multiple case study method on two clusters. Originality/Relevance: The research fills the gap found in the research on clustering and systems dynamics and with the prospect of obtaining more reliable results on the evolution of the cluster's trajectory. Regarding the systemic view of agglomerations, especially around the topic of governance, there seems to be space for a research that involves multiple variables.Results: In both cases, the existence of natural resources was fundamental for the flow of incentives from the public authorities and the support institutions, and for the definition of scope and cooperation, which resulted in positive results for the participants. Over time, it was seen that the perception of limited collective benefits on the part of the players and the weak coordination resulted in the formation of subgroups, with specific interests. Theoretical/methodological contributions: The study employs a system dynamics approach, that highlights a non-linear relation between elements of a system, since this approach has had limited application in existing studies on the governance dynamics of productive agglomerations. The empirical results confirm the influence of the dimensions of governance on the evolution of the agglomerations, demonstrated by the relationships between the elements that compose them, which can inform the construction of scenarios for designing and anticipating future trajectories of productive agglomerations.
Concessão de Crédito e Receita Financeira: Uma Ferramenta de Análise Econômico-Gerencial
Authors: De Amorim Gabriel 
Published: May 2019

Objetivo: Propor um modelo que analisa diversas variáveis consideradas pertinentes para a decisão, como tempo de recebimento, índice de inadimplência sobre vendas a prazo, inflação e/ou custo de capital total da empresa. Contexto/Realidade Investigada: Empresas de pequeno porte criadas a partir da necessidade de seus empreendedores, que se dedicam à gestão, muitas vezes, sem um projeto adequado à realidade do mercado no qual estão inseridos. Normalmente, para aumento no volume de vendas, essas empresas adotam vendas a crédito, sem o uso de intermediador. Diagnóstico/Situação-problema/Oportunidade: A imersão nesse cenário fez com que fosse necessária uma ferramenta para balizar a decisão de concessão ou não da carteira de créditos para empresas de gestão especializadas, cuja expertise permitisse assumir o gerenciamento dos clientes, concentrando os pequenos negócios a desenvolverem-se no seu core business, sem terem de se dedicarem a também analisarem a política de gestão de crédito. O modelo proposto analisa diversas variáveis consideradas pertinentes para a decisão, como tempo de recebimento, índice de inadimplência sobre vendas a prazo, inflação e/ou custo de capital total da empresa. Resultado: O resultado disso é inadimplência e dificuldade de honrar os compromissos assumidos cujo valor tem como decorrência que valores abaixo de 1, calculados, indicam melhores resultados líquidos (financeiros) com a manutenção da gestão própria. Já valores superiores a 1 indicam o melhor desempenho econômico-financeiro dos negócios com a concessão da gestão do capital para empresas especializadas. O modelo foi testado em simulações de fluxo de caixas e mostrou-se coerente em todas elas. Ademais, também é aplicável a quaisquer ramos de negócios.
Autoria nos Artigos Científicos: Por que a Ordem Importa aos Pesquisadores
Authors: Nassif Vânia Maria Jorge 
Published: May 2019

O exercício no papel de editora chefe da REGEPE tem trazido experiências e aprendizagens inusitadas. Ora por saber que há dificuldade da parte dos autores em acatarem a política editorial da revista, de aceitarem uma rejeição sem perder a esperança de que o artigo sempre pode ser melhorado, ora pela responsabilidade ao arbitrar o resultado de uma submissão.Do outro lado, encontramos desafios no contato com os avaliadores, pessoas fundamentais no processo de editoração e guardiões da qualidade técnica-científica de nossa publicação. Essa atividade oculta, missionária e voluntária, embora tenha uma relevância incalculável, tem se tornado mais difícil a cada dia, não pela indisponibilidade ou comodismo, mas pela sobrecarga que todos nós, professores e pesquisadores vivenciamos no cotidiano de nossas atividades profissionais.É inquestionável a pressão por publicação em periódicos de alto impacto a qual somos desafiados, em decorrência das avaliações dos programas e da demonstração da capacidade cientifica dos pesquisadores, que pode colocar em risco a empregabilidade...
MODAL SOSIAL DALAM MENUMBUHKAN DAN MENDIFUSIKAN INOVASI PERTANIAN HORTIKULTURA SEBAGAI BASIS PENGEMBANGAN EKONOMI LOKAL STUDI KASUS: KABUPATEN BANDUNG DAN BANDUNG BARAT
Authors: Tjokropandojo Dewi Sawitri , Aqmarini Ainna , Fiisabiilillah Dika Fajri 
Published: May 2019

Tulisan ini mengeksplorasi pengaruh modal sosial dalam menumbuhkan dan mendifusikan inovasi pertanian hortikultura sebagai basis pengembangan ekonomi lokal. Pendekatan studi yang digunakan adalah pendekatan studi kasus kualitatif, yang didukung oleh teknik analisis pencocokan pola hubungan teoritis dan pola hubungan empiris. Temuan studi ini menunjukkan bahwa modal sosial petani pada kegiatan ekonomi yang relatif lebih tinggi dibanding pada kegiatan sosial dapat menumbuhkan inovasi secara mandiri, lebih meluas dan perkembangannya lebih maju. Modal sosial petani yang relatif tinggi pada kegiatan ekonomi pun dapat mempermudah dan mempercepat proses difusi inovasi serta pendifusiannya berkembang lebih luas, tidak terbatas pada kelompok atau petani tertentu saja. Sementara itu, modal sosial masyarakat petani pada kegiatan sosial yang relatif lebih tinggi dibandingkan pada kegiatan ekonomi tidak menunjukkan adanya dorongan dalam menumbuhkan inovasi secara mandiri dan perkembangan inovasi. Karakteristik modal sosial tersebut juga tidak mempermudah pendifusian inovasi dan proses difusi hanya terjadi pada kelompok petani yang terbatas. Kesimpulannya adalah keberadaan Modal Sosial Petani yang tinggi pada kegiatan ekonomi merupakan kunci Keberlanjutan Pengembangan Ekonomi Lokal Berbasis Pertanian, melalui Pertumbuhan dan Difusi Inovasi Pertanian.
Ricci-flat and Einstein pseudoriemannian nilmanifolds
Authors: Conti Diego , Rossi Federico A. 
Published: May 2019

AbstractThis is partly an expository paper, where the authors’ work on pseudoriemannian Einstein metrics on nilpotent Lie groups is reviewed. A new criterion is given for the existence of a diagonal Einstein metric on a nice nilpotent Lie group. Classifications of special classes of Ricci-˛at metrics on nilpotent Lie groups of dimension [eight.tf] are obtained. Some related open questions are presented.
Silence as an Interlocutor in the Diaspora: Olumide Popoola’s this is not about sadness
Authors: Watkins Jamele 
Published: May 2019

Abstract
This article analyzes silences in the novella this is not about sadness. Using theories of community building by Fatima El-Tayeb, opacity from Édouard Glissant, and theories by Popoola herself, my work argues for the generative way silences function. Silence interweaves the text in community of women and PoCs who create healing and community in shared trauma. Further, the novella articulates diasporic space through language. The use of language is complimented by multiple silences; silences occur when recalling trauma. Violence against Black women looms as trauma occurs in and around the piece, but the novella rejects a narrative of trauma (considering even the title). The narrator continues to exert agency as she continues to narrate the story after her death; just because her life is over, the story is not over. In a novella centering around women, Popoola’s diasporic story also allows for silence; the novella rejects the notion that words are necessary. Featuring multiple narrators, this novella embodies the struggle of and for language as well its emergence in a relational community.
Narrative Constructions of Online Imagined Afro-diasporic Communities in Spain and Portugal
Authors: Borst Julia , González Danae Gallo 
Published: May 2019

Abstract
This article focuses on representative digital platforms created and coordinated by African and Afro-descendant people from Spain and Portugal. It argues that, by sharing and articulating mutual narratives online, these platforms act as spaces where Afro-diasporic communities are being imagined. To that effect, this paper not only builds on theoretical reflections on how Blackness and Afrodescendance are conceptualised on the internet. Adopting a cultural studies’ approach that offers an interpretation of selected posts, it deduces the main narratives displayed and the diverse identificational spaces intertwined in those narratives. In doing so, the paper shows that these platforms challenge biased perspectives on Afro-diasporic communities and, within the digital space, conceptualise alternative, decentred—national and transnational—communities of Afro-diasporic people that are based on shared experiences of displacement, exclusion, resistance and self-empowerment.