bluuebunny/crossref_metadata_2025_split huggingface dataset:
Utilising Text Mining to Determine Japanese Dental Hygiene Students' Perceptions of Dental Hygienists and Dentists
Authors: Susuga Mio , Takahashi Yasuyuki , Iguchi Asami , Motoi Shiho , Hasegawa Yuh 
Published: October 2024

ABSTRACTObjectivesThis longitudinal text‐mining study examines dental hygiene students' perceptions of dental hygienists and dentists at three different points in time during their training course. The null hypothesis of the study was that there would be no change in the dental hygiene students' perceptions of the dental hygienists and dentists over the course of 3 years.Materials and MethodsFirst‐year dental hygiene students participated in this study beginning with the academic year 2020. The questionnaires were conducted in 2020, 2021, and 2022. Participants were asked to write their perceptions of dental hygienists and dentists on the questionnaire sheets, and a quantitative text‐mining analysis was performed.ResultsInitially, 59 female students were assessed for enrollment in this study, and the overall participation rate was 88.1%. The first‐year students' perceptions of dental hygienists were “assist” and “beside” the dentist based on the co‐occurrence group, while in the second‐year, “cleaning” and “tooth” emerged in this group, and a new group of “cordinal‐listen‐story” materialised. In the third year, these groups merged into one group centered on “kind.” In the perceptions of dentists, the word “fear” was the most frequent before clinical training, while the frequency of the world “kind” increased after clinical training. The word “treat” was ranked third in the second year of curriculum and then first in the final year.ConclusionsThe null hypothesis was rejected. It can be concluded that if interactions between dental hygiene and dental students are systematically incorporated from early undergraduate education, clinical practice will be more meaningful and lead to stronger intraprofessional collaboration in future clinical practice.
Factors Associated With Transmission Across Three Waves of SARS‐CoV‐2 in a Prospective Community‐Based Study of Households With School‐Aged Children—Dane County, Wisconsin, 2020–2022
Authors: Sethi Ajay K. , Bell Cristalyne , Norton Derek , Goss Maureen D. , Barlow Shari , Chen Guanhua , Uzicanin Amra , Temte Jonathan L. 
Published: October 2024

ABSTRACTBackgroundHousehold transmission of SARS‐CoV‐2 is a driver of the ongoing COVID‐19 pandemic. Understanding factors that contribute to secondary infection risks (SIRs) can define changing trends and inform public health policies.MethodsThe ORegon CHild Absenteeism due to Respiratory Disease Study (ORCHARDS) prospectively monitors respiratory viruses within the Oregon School District (OSD) in southcentral Wisconsin. Households with students who had ≥ 2 respiratory symptoms were eligible and opted to participate in ORCHARDS. Between October 28, 2020, and May 16, 2022, all household members provided self‐collected nasal specimens on days 0, 7, and 14 for SARS‐CoV‐2 detection using real‐time reverse‐transcription‐polymerase chain reaction. We used logistic regression to investigate individual‐ and household‐level characteristics associated with SARS‐CoV‐2 transmission.ResultsOverall, 127 households comprising 572 individuals (48% female; 52% male; 0.4% nonbinary; 77% ≥ 18 years) had at least one detection of SARS‐CoV‐2. The overall SIR was 47% and decreased over time (pre‐Delta = 72% [95% CI: 58%–83%]; Delta = 51% [40%–63%]; and Omicron = 41% [36%–47%]). Odds of household transmission were 63% lower during the Omicron period compared with the pre‐Delta period (OR = 0.36 [95% CI: 0.13–0.94] p = 0.037). Greater household density (members/bedroom) was significantly associated with household transmission during the Omicron period (OR = 6.8, [2.19–21.37] p = 0.001). Index case age, illness severity, and individual symptoms were not significantly associated with odds of household transmission.ConclusionsGreater household density was associated with a higher risk of SARS‐CoV‐2 transmission, but the risk declined over time with subsequent variants. Interplay between variants, prior infection, and individual/household factors may identify modifiable factors (e.g., behavior and vaccination) to reduce future transmission risk.
Consumer‐Centric Supply Chain Management: A Literature Review, Framework, and Research Agenda
Authors: Baldi Benedetta , Confente Ilenia , Russo Ivan , Gaudenzi Barbara 
Published: October 2024

ABSTRACTThe dynamic landscape of consumer behavior is pressuring companies to adapt to rapidly evolving consumer expectations. The burgeoning interest in the supply chain management (SCM) literature toward consumer‐centric research is capturing the attention of scholars and sparking diverse calls to action. While a significant growth in SCM research has centered on consumers as the unit of analysis over the past decade, it remains necessary to improve understanding of how the role of consumers as actors within the supply chain dynamic has evolved. We aim to enhance consumer‐centric SCM research by conducting a systematic literature review that summarizes and synthesizes SCM studies that focus on consumers as the unit of analysis. Our review encompasses 174 articles from 16 leading journals. We bundle the literature based on two key trajectories: (i) major functions involved in SCM activities, and (ii) phases of the customer journey. To synthesize the literature, we develop a framework that encompasses the following elements: (i) factors influencing consumer‐centric SCM, (ii) resultant consumer‐related outcomes, and (iii) retail supply chain structures. Based on the literature review, we propose a research agenda that serves as a basis for advancing SCM research by identifying research questions that are relevant to scholars and practitioners.
Wearable smart glasses for first‐person video analysis to evaluate nursing skills: A pilot study with a mixed method design
Authors: Kim Sun Kyung , Lee Youngho , Hwang Hye Ri , Kim Oe Nam 
Published: October 2024

AbstractBackgroundComprehensive assessment of skills and performance are necessary to improve the quality of care in nursing education. Various factors pose challenges to accurate assessments, including high student–teacher ratio and observer bias.ObjectivesTo establish an assessment system based on first‐person video of smart glasses and validate its usability and feasibility.MethodsWe used two cameras (smart glasses for first‐person perspective and a web cam) to perform video analysis for skill and performance assessments. Usability tests were conducted using quantitative and qualitative questionnaires for the usefulness and acceptability of the current assessment system. Data from standardised checklists for three clinical nursing skills (intramuscular injection, endotracheal suction, and Levin tube feeding) were used to analyse the inter‐rater reliability in addition to Fleiss' Kappa coefficient analysis. A total of 22 participants (18 students and 4 reviewers) were recruited. They completed the study. Apart from physical discomfort component, the proposed smart glasses‐based first‐person video assessment system achieved good usability scores from both students and reviewers.Results and ConclusionsFleiss' Kappa values for individual items ranged from 0.450 to 0.808, with an overall average value of 0.592. Results of this study validated the potential of smart glasses‐based assessment system where a set of beneficial mechanisms may meaningfully support the formative learning process. However, issues regarding upgrading the device and need for guidelines for roles of raters and students still remain.
Caffeic acid inhibits Staphylococcus aureus‐induced endometritis through regulating AMPKα/mTOR/HIF‐1α signalling pathway
Authors: Cao Lu , Liu Junbao , Ye Cong , Hu Yubo , Qin Rui 
Published: October 2024

AbstractEndometritis is mostly caused by childbirth or postpartum uterine infection. It is one of the important reasons leading to female infertility. Caffeic acid (CA) and its derivatives are widely found in some foods and traditional Chinese medicine, and have biological activities such as antioxidant, free radical scavenging, anti‐inflammatory, and anti‐infection. In this study, we aimed to explore the effect of CA on Staphylococcus aureus‐induced endometritis. The contents of TNF‐α and IL‐1β were detected by ELISA in S. aureus‐induced endometritis model. Western blot assay was used to detect the expression of AMPKα/mTOR/HIF‐1α pathway related proteins and GPX4 expression. In addition, the concentrations of MDA, GSH, and iron were tested by the assay kits. Compared with the model group, CA treatment significantly alleviated S. aureus‐induced uterine injury, MPO activity, the contents of inflammatory factors TNF‐α and IL‐1β, and NF‐κB activation. Meanwhile, CA significantly inhibited S. aureus‐induced ferroptosis, as confirmed by decreased MDA and iron concentration and up‐regulated GPX4 expression and GSH level. Furthermore, CA attenuated S. aureus‐induced HIF‐1α and phosphorylated mTOR expression and increased phosphorylated AMPK expression. In conclusion, CA inhibits inflammation and ferroptosis by regulating AMPKα/mTOR/HIF‐1α signalling pathway to alleviate S. aureus‐induced endometritis in mice.
KRAS mutation promotes the colonization of Fusobacterium nucleatum in colorectal cancer by down‐regulating SERTAD4
Authors: Chen Yizhen , Zheng Yuanyuan , Liu Shaolin 
Published: October 2024

AbstractThis study explores and verifies potential molecular targets through which KRAS mutations regulate the colonization of Fusobacterium nucleatum (FN) in colorectal cancer (CRC). This study combined multiple bioinformatics methods and biological assays. Through The Cancer Genome Atlas, Gene Expression Omnibus, Human Protein Atlas, immunohistochemistry, and co‐culture assays, we further confirmed the differential expression of SERTAD4 in CRC. We delved deeper into examining how expression of SERTAD4 is linked with immune cell infiltration and the enrichment of potential pathways. Lastly, through bacterial phenotypic assays, we validated the function of SERTAD4. As a molecule associated with KRAS mutations and FN infection, the expression levels of SERTAD4 were downregulated in CRC. The diagnostic efficacy of SERTAD4 for CRC is not inferior to that of CEA. Low expression of SERTAD4 is associated with poorer overall survival in CRC. Correlation analysis found that increased expression of SERTAD4 is associated with various immune cell infiltrations and immune checkpoint genes. Finally, bacterial adhesion and invasion assays verify that SERTAD4 inhibits the adhesion and invasion abilities of FN in CRC. This study demonstrates that SERTAD4 exerts a protective role in CRC by inhibiting the colonization of FN.
Food choice and neural reward systems in adolescents with anorexia nervosa and atypical anorexia nervosa
Authors: Lloyd E. Caitlin , Posner Jonathan , Schebendach Janet , Muratore Alexandra F. , Hong Susie , Ojeda Jessica , Rafanello Elizabeth , Steinglass Joanna E. , Foerde Karin 
Published: October 2024

BackgroundAdolescence is a critical developmental period for the study of anorexia nervosa (AN), an illness characterized by extreme restriction of food intake. The maturation of the reward system during adolescence combined with recent neurobiological models of AN led to the hypothesis that early on in illness, restrictive food choices would be associated with activity in nucleus accumbens reward regions, rather than caudate regions identified among adults with AN.MethodsHealthy adolescents (HC, n = 41) and adolescents with AN or atypical AN (atypAN, n = 76) completed a Food Choice Task during fMRI scanning. Selection of high‐fat foods and choice‐related activation in nucleus accumbens and anterior caudate regions‐of‐interest (ROIs) were compared between individuals with AN/atypAN and HC. Associations were examined between choice‐related activation and choice preferences among the AN group. Exploratory analyses examined associations between choice‐related activation and psychological assessments among the patient group.ResultsAdolescents with AN or atypAN selected fewer high‐fat foods than HC (t = −5.92, p < .001). Counter to predictions, there were no significant group differences in choice‐related activation in the ROIs. Among individuals with AN or atypAN, choice‐related neural activity in the anterior caudate was significantly negatively associated with high‐fat food selections in the task (r = −.32, p = .024). In exploratory analyses, choice‐related anterior caudate activation was positively associated with psychological measures of illness severity among patients (p's < .05, uncorrected).ConclusionsIn this large cohort of adolescents with AN/atypAN, there was no evidence of altered reward system engagement during food choice. While there was no group difference in choice‐related caudate activation, the associations with choices and psychological measures continue to suggest that this neural region is implicated in illness. Longitudinal analyses will clarify whether neural variability relates to longer‐term course.
Efficacy of Subdermal Poly‐d,l‐Lactic Acid Injections for the Treatment of Melasma
Authors: Wan Jovian , Yi Kyu‐Ho 
Published: October 2024

ABSTRACTBackgroundMelasma is a chronic, recurrent skin disorder with limited long‐term treatment success using conventional therapies like hydroquinone and laser treatments, which primarily target epidermal components while leaving dermal aspects untreated.ObjectiveTo evaluate the efficacy and safety of poly‐d,l lactic acid (PDLLA) subdermal injections for treating moderate melasma.MethodsThree female patients (age range: 45–59 years) with Fitzpatrick skin types III and IV received three PDLLA injection sessions at 3‐week intervals. Treatment outcomes were assessed using the Melasma Area and Severity Index (MASI) and patient satisfaction scores at 12‐week follow‐up.ResultsAll patients showed significant MASI score improvements (reduction range: 3.60–6.30 points). Patient satisfaction ratings ranged from 3 to 4 out of 4. Temporary side effects included mild edema and bruising, resolving within 72 h.ConclusionsPDLLA subdermal injections showed promising results in melasma treatment, potentially due to its biostimulatory effects on collagen production and dermal remodeling. Further research, including histopathological analysis, is needed to confirm long‐term efficacy and safety, and understand underlying mechanisms.
Patient experiences of narcolepsy and idiopathic hypersomnia in the Nordics: a patient journey map
Authors: Vesinurm Märt , Dünweber Christina , Rimestad Jesper , Landtblom Anne‐Marie , Jennum Poul Jørgen 
Published: October 2024

SummaryCentral disorders of hypersomnolence (CDH) are chronic diseases that significantly impact the lives of affected individuals. We aimed to explore the perspectives of individuals with narcolepsy type 1 (NT1), narcolepsy type 2 (NT2), and idiopathic hypersomnia (IH), and the challenges they encounter in their daily lives and within the healthcare systems in the Nordics. Interviews with patients (N = 41) and healthcare professionals (n = 14) and a patient survey (n = 70) were conducted in 2022 in Denmark, Sweden, Finland, and Norway to develop a patient journey map that visualises the patient with CDH journey and provides insights into the difficulties faced by these individuals. The patient journey mapping approach was chosen to focus on the processes and experiences of patients, highlighting the challenges they confront. Our findings revealed that the process of receiving a CDH diagnosis, as well as subsequent misdiagnoses and treatment, can be protracted and burdensome. CDH diagnoses remain poorly understood by neurologists, general practitioners, and the public, resulting in adverse consequences, with patients reporting a mean (standard deviation [SD]) time from symptom onset to diagnosis of 8.4 (5.11) years and a mean (SD) of 5.5 (4.17) productive hours lost/day. The available non‐pharmaceutical support for patients with CDH, encompassing medical, psychological, educational, and professional assistance, was insufficient. The generalisability of the findings to one specific diagnosis is limited due to the collective analysis of the CDH. These findings are invaluable for identifying disruptions in the patient with CDH journeys and for designing improved pathways for those with NT1, NT2, and IH in the future.
Comparative Pharmacokinetics of Intravenous and Subcutaneous Omeprazole in Sheep and Goats
Authors: Serih Firas , Fadel Charbel , Łebkowska‐Wieruszewska Beata , Lisowski Andrzej , Poapolathep Amnart , Giorgi Mario 
Published: October 2024

ABSTRACTAbomasal ulcers are a challenge in animal farming, affecting health, welfare, and productivity. Omeprazole's (OPZ) efficacy in treating these ulcers is known, but data on its pharmacokinetics (PK) in adult goats and sheep are lacking. The purpose of this research was to investigate and contrast OPZ's PK in these animals following a single intravenous (IV, 1 mg/kg) and subcutaneous (SC, 2 mg/kg) doses. Sheep and goats had similar exposure levels for all administration routes, with no significant AUC(0‐∞)D variations. Half‐life was short in both species (sheep: 0.20 h; goats: 0.31 h). Goats had a higher volume of distribution after IV administration. Clearance was rapid, and extraction ratio values were high for both goats and sheep (43% and 30%, respectively). SC administration showed similarities in Cmax and Tmax values between species. Both goats and sheep had high bioavailability (about 80%) levels and comparable mean absorption times (MAT). Despite some PK parameters' variances, systemic exposure to OPZ is similar in sheep and goats. SC administration's high bioavailability suggests it as a convenient field application route. Further investigations are needed to understand OPZ's effectiveness in small ruminants with abomasal ulcers and improve dosing regimens for clinical use.
Developmental eye movement test results of Hebrew‐speaking children with cross‐linguistic comparisons
Authors: Ben‐Eli Hadas , Blique Hadas , Scheiman Mitchell , Eichler Rachel 
Published: October 2024

AbstractIntroduction and PurposeThe developmental eye movement (DEM) test is designed to assess saccadic eye movements and visual‐verbal automaticity in children. This study aimed to assess whether there is a need for independent DEM Hebrew norms and to compare DEM results for Hebrew‐speaking children with eight other language norms.MethodsThe DEM test was administered to 224 Hebrew‐speaking children aged 6–13 years who met the inclusion criteria and read the numbers in Hebrew. Test C of the DEM was performed twice, once from right (R) to left (L) and once from L to R, in random order. Age group and language comparisons, including vertical and horizontal reading speeds, errors and horizontal/vertical (H/V) ratios in both directions were analysed.ResultsThe participants were almost evenly distributed between the sexes (46.8% female). Statistically significant differences were found between age groups (6–9 and 10–13 years) for vertical and horizontal reading speeds and H/V ratios in both directions (p < 0.001). Older children, as compared to younger children, exhibited faster vertical and horizontal times, with fewer errors, as well as lower ratios (p < 0.001). No significant difference was noted between reading directions for horizontal time and H/V ratio within both age groups (6–9 year olds: p = 0.27 and p = 0.06; 10–13 year olds: p = 0.89 and p = 0.49, respectively). Comparison of DEM norms across languages showed significant differences, with post‐hoc analysis revealing specific language‐related variations. DEM results for Hebrew‐speaking children had similar outcomes to both original English and French values.ConclusionsThis study compared DEM results of Hebrew‐speaking children and scores across nine languages. DEM test values for Hebrew‐speaking children aligned with norms from other languages, particularly the French and original English norms, with consistent ratio scores. It is recommended for practitioners who test Hebrew‐speaking children to continue using the original English norms and to enable the children to read using their preferred reading direction.
Exploring the Combinatorial Effects of Collaborative Factors Leading to Higher Degree of Co‐Production
Authors: Wang Huanming , Zhang Sihan , Ran Bing 
Published: October 2024

ABSTRACTThis study investigates the collaborative factors conducive to co‐production in public services, utilizing Ansell and Gash's framework and fuzzy set qualitative comparative analysis (fsQCA) across 18 cases from the Collaborative Governance Case Database (CGCD). It identifies incentive as a necessary condition for co‐production, revealing three sufficient pathways to co‐production: managed, led, and self‐organized co‐production. The findings advance our understanding of the specific collaborative configurations that can achieve higher degree of co‐production, offering an “incentive‐structure‐behavior” framework and practical insights for policy makers seeking to enhance public service co‐production.
The Lipid Droplet Protein DHRS3 Is a Regulator of Melanoma Cell State
Authors: Johns Eleanor , Ma Yilun , Louphrasitthiphol Pakavarin , Peralta Christopher , Hunter Miranda V. , Raymond Jeremy H. , Molina Henrik , Goding Colin R. , White Richard M. 
Published: October 2024

ABSTRACTLipid droplets are fat storage organelles composed of a protein envelope and lipid‐rich core. Regulation of this protein envelope underlies differential lipid droplet formation and function. In melanoma, lipid droplet formation has been linked to tumor progression and metastasis, but it is unknown whether lipid droplet proteins play a role. To address this, we performed proteomic analysis of the lipid droplet envelope in melanoma. We found that lipid droplet proteins were differentially enriched in distinct melanoma states; from melanocytic to undifferentiated. DHRS3, which converts all‐trans‐retinal to all‐trans‐retinol, is upregulated in the MITFLO/undifferentiated/neural crest‐like melanoma cell state and reduced in the MITFHI/melanocytic state. Increased DHRS3 expression is sufficient to drive MITFHI/melanocytic cells to a more undifferentiated/invasive state. These changes are due to retinoic acid‐mediated regulation of melanocytic genes. Our data demonstrate that melanoma cell state can be regulated by expression of lipid droplet proteins which affect downstream retinoid signaling.