bluuebunny/crossref_metadata_2025_split huggingface dataset:
Psychometric Validation of the Role Function Restrictive Domain of the Migraine Specific Quality‐of‐Life Questionnaire Version 2.1 Electronic Patient‐Reported Outcome in Patients With Episodic and Chronic Migraine
Authors: Speck Rebecca M. , Shalhoub Huda , Wyrwich Kathleen W. , Yu Ren , Ayer David W. , Ford Janet , Bush Elizabeth N. , Lipton Richard B. 
Published: March 2019

ObjectivesTo assess the measurement properties of the Migraine‐Specific Quality of Life Questionnaire version 2.1 (MSQv2.1) electronic patient‐reported outcome (ePRO) Role Function‐Restrictive (RFR) domain to evaluate the functional impact of migraine in patients with episodic (EM) or chronic migraine (CM) enrolled in clinical trials.MethodsThe 7‐item MSQv2.1 ePRO RFR measures the functional impact of migraine on relationships with family and friends, leisure time, work or daily activities, productivity, concentration, tiredness, and energy. Measurement properties of the RFR were assessed using data from 2 EM (CGAG [n = 851] and CGAH [n = 909]) and 1 CM (CGAI [n = 1090]) Phase 3 galcanezumab clinical trials. Anchor‐ and distribution‐based analyses were utilized to derive a responder threshold for clinical interpretation of change over time. The Migraine Disability Assessment (MIDAS), Patient Global Impression of Severity (PGI‐S), Patient Global Impression of Improvement (PGI‐I), and migraine headache days (MHD) served as anchors. Responsiveness and responder threshold analyses were completed from baseline to the average of months 4‐6 for EM studies, and from baseline to month 3 for the CM study; timeframes selected were based on the primary endpoints in these studies.ResultsCronbach’s alpha values for internal consistency reliability were 0.93, 0.92, and 0.92, for CGAG, CGAH, and CGAI, respectively. Test–retest reliability intra‐class correlation coefficients were 0.82 and 0.84 for CGAG and CGAH, and 0.85 for CGAI in stable patients. Convergent validity was supported by moderate to strong correlations (≥0.30) between the RFR and both MIDAS and PGI‐S. Known‐groups validity was established between subgroups stratified by baseline PGI‐S and MHD (P < .05; δ = 0.35‐1.96). For the EM studies, anchor variables suggested a change of ≥25 points (equivalent to 9 points/state changes on raw scale) in the RFR was an appropriate threshold to interpret a treatment benefit. For the CM study a change of ≥17.14 points (6 points/state changes on raw scale) was an appropriate threshold. In all 3 studies, significantly (P < .01) more galcanezumab patients achieved the responder definition thresholds, as compared to placebo (odds ratios of 1.98, 2.45, 2.27, 2.44, 1.64, and 1.66 for the 120 and 240 mg arms in the CGAG, CGAH, and CGAI trials, respectively).ConclusionThe MSQv2.1 ePRO RFR has sufficient reliability, validity, responsiveness, and appropriate interpretation standards for use in EM and CM clinical trials to assess the functional impact of migraine.
Personalized therapy for Helicobacter pylori: CYP2C19 genotype effect on first‐line triple therapy
Authors: Arévalo Galvis Azucena , Trespalacios Rangel Alba Alicia , Otero Regino William 
Published: March 2019

AbstractBackgroundTriple therapy efficacy against Helicobacter pylori is low worldwide, and thus, alternatives must be sought to improve eradication. The aim of the present study was to determine CYP2C19 genetic polymorphism effect on H pylori eradication.MethodsA randomized, single‐blinded clinical trial including 133 participants was carried out. H pylori infection was confirmed by histologic and microbiologic test. Antibiotic susceptibility to amoxicillin and clarithromycin was performed. CYP2C19 polymorphisms *1, *2, and *3 were analyzed by real‐time PCR (Roche ®), and nested PCR for CYP2C19*17 polymorphisms. Participants were randomized into two groups for different H pylori therapies, one with standard omeprazole doses and another with omeprazole doses depending on CYP2C19 polymorphism. H pylori eradication was verified by stool antigen tests (Meridian ®).ResultsThe most common CYP2C19 polymorphism was *1/*1 in 54.9% of the participants followed by *17/*17 in 21.1%. Triple therapy efficacy with standard omeprazole doses versus personalized therapy based on CYP2C19 polymorphism by ITT analysis was 84% (95% CI: 0.73‐0.91) vs 92.2% (95% CI: 0.82‐0.97) (P = 0. 14), respectively. The efficacy by PP analysis was 92.1% (95% CI: 0.82‐0.97) vs 100% (95% CI: 0.92‐0.01) (P = 0.027), respectively.ConclusionsThe most frequent polymorphism was extensive PPI metabolizers (62.4%). Effectiveness of guided therapies by susceptibility test was good, yet they can be further improved by customized therapy based on CYP genotype. Therefore, high PPI (80 mg/d) doses are recommended for H pylori eradication therapies in Colombia.ClinicalTrials.gov ID: NCT03650543.
Clinicopathological evaluation of the programmed cell death 1 (PD1)/programmed cell death‐ligand 1 (PD‐L1) axis in post‐transplant lymphoproliferative disorders: association with Epstein–Barr virus, PD‐L1 copy number alterations, and outcome
Authors: Veloza Luis , Teixido Cristina , Castrejon Natalia , Climent Fina , Carrió Ana , Marginet Marta , Soldini Davide , González‐Farré Blanca , Ribera‐Cortada Inmaculada , Lopez‐Guillermo Armando , González‐Barca Eva , Sierra Adriana , Herrera Mileyka , Gómez Cándida , Garcia Adriana , Balagué Olga , Campo Elias , Martinez Antonio 
Published: March 2019

AimsThe clinical implications of the programmed cell death 1 (PD1)/programmed cell death‐ligand 1 (PD‐L1) axis in patients with post‐transplant lymphoproliferative disorders are largely unknown, and its association with Epstein–Barr virus (EBV) status and PD‐L1 copy number alterations (CNAs) has not been thoroughly studied.Methods and resultsPD1/PD‐L1 expression was studied in 50 adult post‐transplant lymphoproliferative disorders, and the correlations with PD‐L1 CNAs, EBV, clinicopathological features and outcome were evaluated. Thirty‐seven (74%) cases were classified as diffuse large B‐cell lymphoma (DLBCL), nine (18%) cases were classified as polymorphic, and four (8%) cases were classified as classic Hodgkin lymphoma. Thirty‐four cases were EBV‐positive, with 29 of 34 (85%) having latency II or III, and 15 of 34 (44%) having viral replication. PD‐L1 expression in tumour cells and tumour‐associated macrophages was observed in 30 (60%) and 37 (74%) cases, respectively. PD1 positivity was seen in 16 (32%) cases. PD‐L1 expression was associated with EBV with latency II or III (P = 0.001) and organ rejection (P = 0.04), and, in DLBCL, with non‐germinal centre type DLBCL (P < 0.001). Cases with PD‐L1‐positive tumour cells showed a higher number of PD‐L1 CNAs than PD‐L1‐negative cases (P = 0.001). Patients with EBV/latency III/replication and simultaneous PD‐L1 expression showed the worst overall survival (P < 0.001).ConclusionsThe PD1/PD‐L1 axis is deregulated in post‐transplant lymphoproliferative disorders, with frequent PD‐L1 expression and PD1 negativity. PD‐L1 expression is associated with EBV latency II or III and PD‐L1 CNAs, and probably reflects a proinflammatory tumour microenvironment. The combined analysis of EBV status and PD‐L1 expression may help to identify deeply immunosuppressed patients who can benefit from immune reconstitution approaches.
POSTPOSITIVISM AND THE LOGIC OF THE AVANT‐GARDE
Authors: GRIGORIEV SERGE 
Published: March 2019

ABSTRACTThe purpose of this article is to explore the conditions under which the postpositivist interest in rewriting or reinterpreting history could operate legitimately from a historical point of view. The first part of the article outlines and explains some of the key thematic elements of historical postpositivism. The second proceeds to investigate how these elements can be configured and related to each other within Arthur Danto's influential account of the development of contemporary art, and especially the avant‐garde. The intention is to acquire a sense of the working dynamics of postpositivist thought, so as to better understand its possible implications for the writing of history. In the concluding section an argument is proposed to the effect that, although the postpositivist interest in the rewriting of history can in principle be admitted as entirely legitimate, its legitimacy depends on introducing some substantive constraints on content, in addition to the formal considerations that postpositivist discourse generally tends to favor. It is further suggested that this constraint should take the form of a requirement on historical literacy whose meaning is, finally, elucidated by drawing a contrast with historical common sense.
FROM LEFT‐WING TO COMMUNIST MELANCHOLY: TRAVERSO'S WAGER
Authors: Plass Ulrich 
Published: March 2019

ABSTRACTEnzo Traverso's inspired book Left‐Wing Melancholia revisits iconic representations of revolutionary hopes and defeats not to draw up an inventory of what has been lost but rather to remind his readers that past defeats also contain the traces of unfulfilled possibilities. After the end of the Soviet Union and the global triumph of neoliberal capitalism, the communist utopian imagination of a classless society, Traverso suggests, can be reignited through memorial practices of resilient, resistant melancholy. Traverso's argument draws on Walter Benjamin's notions of materialist history, redemptive memory, and knowing melancholy. Yet the nameless vanquished masses to whom Benjamin's concept of history seeks to do justice remain marginal in Traverso's book. Instead, revolutionary defeat is cast in the tragic mold of succeeding by failing, a trope exemplified by figures such as Auguste Blanqui, Charles Péguy, or Daniel Bensaïd. In response to Traverso's reliance on the transhistorical category of the tragic, this essay argues for a more abstractly theoretical understanding of left‐wing melancholy as conditioned by historically specific class relations that constrain and challenge the engaged intellectual. Moreover, this essay questions Traverso's dualistic treatment of politically committed (Benjamin, Brecht, C. L. R. James) and elitist intellectuals (Adorno) and concludes that the concept of left‐wing melancholy must ultimately be interrogated against the backdrop of a lingering uncertainty about the relationship between theory and praxis that, as Adorno claims, one can already find in Karl Marx—an uncertainty that is hence inscribed into the history of any Marxist theory of revolution and history.
The accuracy of CBCT for the detection and diagnosis of vertical root fractures in vivo
Authors: Byakova S. F. , Novozhilova N. E. , Makeeva I. M. , Grachev V. I. , Kasatkina I. V. 
Published: March 2019

AbstractAimTo compare the in vivo accuracy of CBCT for the detection of fracture lines versus the diagnosis of vertical root fractures (VRFs) according to characteristic patterns of associated bone resorption.MethodologyEighty‐eight patients with symptoms typical of VRFs in root filled teeth, who underwent a CBCT examination and later had the teeth extracted, were divided into two groups: the fracture group (n = 65) and the control group (n = 23). Five blinded observers assessed the CBCT images in two sessions. During the first session, they were asked to state the diagnosis according to the CBCT and clinical data. During the second session after 2 weeks, they assessed only axial slices and were asked to detect a fracture line. The mean CBCT specificity, sensitivity, accuracy values and area under the receiver operating characteristic (AUROC) curve were calculated and compared using the Wilcoxon signed‐rank test.ResultsThe average sensitivity of CBCT for the diagnosis of VRFs was 0.84 ± 0.2. The accuracy and AUC values were 0.81 ± 0.08 and 0.84 ± 0.17, respectively. The sensitivity, accuracy and AUC values for the detection of VRFs were significantly lower: 0.17 ± 0.24 (P = 0.042), 0.54 ± 0.07 (P = 0.043), and 0.52 ± 0.09 (P = 0.043), respectively. The specificity of CBCT for the detection and diagnosis of VRFs did not differ significantly (P = 0.50).ConclusionCone‐beam computed tomography was helpful in VRF diagnosis even when it was not possible to visualize the fracture line.
Effect of apple cider vinegar agent on the microstructure, phase evolution, and magnetic properties of CoFe2O4 magnetic nanoparticles
Authors: Afshari Mohammad , Rouhani Isfahani Amir‐Reza , Hasani Saeed , Davar Fatemeh , Jahanbani Ardakani Khadijeh 
Published: March 2019

AbstractIn the present study, spinel structure CoFe2O4 nanoparticles were successfully synthesized by the sol‐gel auto‐combustion technique. The effect of apple cider vinegar (ACV) addition as an organic biocompatible agent on the size, morphology, and magnetic properties of CoFe2O4 nanoparticles was investigated in detail. The phase evolution, particle size, and lattice parameter changes of the synthesized phase have been estimated by using Rietveld structure refinement analysis of X‐ray powder diffraction data. Also, Fourier transform infrared spectra (FT‐IR) of the samples verified the presence of two expected bands correspond to tetrahedral and octahedral metal‐oxygen complexes within the spinel structure. Furthermore, microstructural observations revealed that ultrafine particles have a semi‐spherical morphology. It was shown that the particles size decreased from ~45 to ~17 nm with an increase in the amount of ACV. Magnetic properties were carried out by vibrating sample magnetometer (VSM) at room temperature. Both the saturation magnetization (Ms) and coercivity (Hc) were found to be significantly dependent on the crystallite size and the amount of ACV.
Maturity‐onset diabetes of the young type 5 uncovered during pregnancy with a long‐term diagnosis of type 1 diabetes
Authors: Deng Mingqun , Wang Xiaojing , Xiao Xinhua , Ping Fan 
Published: March 2019

AbstractWe report a case of missed diagnosis of maturity‐onset diabetes of the young type 5 uncovered during pregnancy with a previous diagnosis of type 1 diabetes. Maturity‐onset diabetes of the young type 5 cannot be excluded in early‐onset diabetes with positive islet‐related autoantibodies and type 1 diabetes‐prone human leukocyte antigen subtypes. Abdominal ultrasound should be used in all patients with pre‐gestational diabetes, and maturity‐onset diabetes of the young type 5 should be considered when renal abnormality is presented.
Na+/K+‐ATPase gene duplications in clitellate annelids are associated with freshwater colonization
Authors: Horn Kevin M. , Williams Bronwyn W. , Erséus Christer , Halanych Kenneth M. , Santos Scott R. , Creuzé des Châtelliers Michel , Anderson Frank E. 
Published: March 2019

AbstractMajor habitat transitions, such as those from marine to freshwater habitats or from aquatic to terrestrial habitats, have occurred infrequently in animal evolution and may represent a barrier to diversification. Identifying genomic events associated with these transitions can help us better understand mechanisms that allow animals to cross these barriers and diversify in new habitats. Study of the Capitella telata and Helobdella robusta genomes allows examination of one such habitat transition (marine to freshwater) in Annelida. Initial examination of these genomes indicated that the freshwater leech H. robusta contains many more copies (12) of the sodium–potassium pump alpha‐subunit (Na+/K+‐ATPase) gene than does the marine polychaete C. telata (2). The sodium–potassium pump plays a key role in maintenance of cellular ionic balance and osmoregulation, and Na+/K+‐ATPase duplications may have helped annelids invade and diversify in freshwater habitats. To assess whether the timing of Na+/K+‐ATPase duplications coincided with the marine‐to‐freshwater transition in Clitellata, we used transcriptomic data from 18 annelid taxa, along with the two genomes, to infer a species phylogeny and identified Na+/K+‐ATPase gene transcripts in order to infer the timing of gene duplication events using tree‐based methods. The inferred timing of Na+/K+‐ATPase duplication events is consistent with the timing of the initial marine‐to‐freshwater transition early in the history of clitellate annelids, supporting the hypothesis that gene duplications may have played a role in the annelid diversification into freshwater habitats.
Inter‐individual maternal care received and genotype interactions affect dopaminergic phenotypes in female rat offspring
Authors: Lauby Samantha C. , Chatterjee Diptendu , Pan Pauline , McGowan Patrick O. , Fleming Alison S. 
Published: March 2019

Rat mothers exhibit natural variations in care and can shape offspring adult behaviour and their maternal care by affecting the dopaminergic system. We explored whether genotype and gene × environment interactions are involved in these processes in nulliparous female offspring. We assessed maternal licking/grooming toward individual female pups during the first week postpartum and dopamine‐related behaviour of the offspring in adulthood. Behaviours explored included strategy shifting, impulsive action and sucrose preference. Single nucleotide polymorphisms in the dopamine receptor 2, dopamine transporter and catechol‐O‐methyltransferase genes were examined in relation to offspring behaviour and baseline dopamine turnover in select brain regions. Dopamine receptor 2 (RS107017253) variation moderated, or interacted with, the relationship between early‐life licking received and behaviour. Specifically, offspring with the A/A genotype showed a significant correlation between early‐life licking received and behaviour. Offspring with the A/G and G/G genotypes did not show this relationship. Dopamine transporter gene variation affected offspring behaviour regardless of early‐life licking received. Our findings suggest that genotype can directly affect dopamine‐related behaviours and alter the sensitivity of offspring to the maternal environment. This could be informative on how maternal care is transmitted between generations of female offspring.
Cajal‐Retzius neurons are required for the development of the human hippocampal fissure
Authors: Meyer Gundela , González‐Arnay Emilio , Moll Ute , Nemajerova Alice , Tissir Fadel , González‐Gómez Miriam 
Published: March 2019

AbstractCajal‐Retzius neurons (CRN) are the main source of Reelin in the marginal zone of the developing neocortex and hippocampus (HC). They also express the transcription factor p73 and are complemented by later‐appearing GABAergic Reelin+ interneurons. The human dorsal HC forms at gestational week 10 (GW10), when it develops a rudimentary Ammonic plate and incipient dentate migration, although the dorsal hippocampal fissure (HF) remains shallow and contains few CRN. The dorsal HC transforms into the indusium griseum (IG), concurrently with the rostro‐caudal appearance of the corpus callosum, by GW14–17. Dorsal and ventral HC merge at the site of the former caudal hem, which is located at the level of the future atrium of the lateral ventricle and closely connected with the choroid plexus. The ventral HC forms at GW11 in the temporal lobe. The ventral HF is wide open at GW14–16 and densely populated by large numbers of CRNs. These are in intimate contact with the meninges and meningeal blood vessels, suggesting signalling through diverse pathways. At GW17, the fissure deepens and begins to fuse, although it is still marked by p73/Reelin+ CRNs. The p73KO mouse illustrates the importance of p73 in CRN for HF formation. In the mutant, Tbr1/Reelin+ CRNs are born in the hem but do not leave it and subsequently disappear, so that the mutant cortex and HC lack CRN from the onset of corticogenesis. The HF is absent, which leads to profound architectonic alterations of the HC. To determine which p73 isoform is important for HF formation, isoform‐specific TAp73‐ and DeltaNp73‐deficient embryonic and early postnatal mice were examined. In both mutants, the number of CRNs was reduced, but each of their phenotypes was much milder than in the global p73KO mutant missing both isoforms. In the TAp73KO mice, the HF of the dorsal HC failed to form, but was present in the ventral HC. In the DeltaNp73KO mice, the HC had a mild patterning defect along with a shorter HF. Complex interactions between both isoforms in CRNs may contribute to their crucial activity in the developing brain.
The face of postural tachycardia syndrome – insights from a large cross‐sectional online community‐based survey
Authors: Shaw B. H. , Stiles L. E. , Bourne K. , Green E. A. , Shibao C. A. , Okamoto L. E. , Garland E. M. , Gamboa A. , Diedrich A. , Raj V. , Sheldon R. S. , Biaggioni I. , Robertson D. , Raj S. R. 
Published: March 2019

AbstractBackgroundPatients with postural tachycardia syndrome (POTS) experience chronic symptoms of orthostatic intolerance. There are minimal data detailing the demographics, clinical features and clinical course of this condition. This online, community‐based survey highlights patients’ experience with POTS. It consists of the largest sample of POTS patients reported to date.ObjectivesTo describe the demographics, past medical history, medications, treatments and diagnostic journey for patients living with POTS.MethodsPostural tachycardia syndrome patients completed an online, community‐based, cross‐sectional survey. Participants were excluded if they had not received a diagnosis of POTS from a physician. The questions focused on the patient experience and journey, rather than physiological responses.ResultsThe final analysis included 4835 participants. POTS predominantly affects white (93%) females (94%) of childbearing age, with approximately half developing symptoms in adolescence (mode 14 years). POTS is a chronic multisystem disorder involving a broad array of symptoms, with many patients diagnosed with comorbidities in addition to POTS. POTS patients often experience lengthy delays [median (interquartile range) 24 (6–72) months] and misdiagnosis, but the diagnostic delay is improving. POTS patients can present with a myriad of symptoms most commonly including lightheadedness (99%), tachycardia (97%), presyncope (94%), headache (94%) and difficulty concentrating (94%).ConclusionsThese data provide important insights into the background, clinical features and diagnostic journey of patients suffering from POTS. These data should serve as an essential step for moving forward with future studies aimed at early and accurate diagnoses of these patients leading to appropriate treatments for their symptoms.