bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hubungan Antara Paradigma Lingkungan Baru Dengan Perilaku Tanggung Jawab Lingkungan Siswa
Authors: Kaan Septika Augis Ulmi , Putrawan I Made , Miarsyah Mieke 
Published: February 2019

Responsible environmental behavior is the result of interaction between various factors. One of those factors is the new environmental paradigm. This study aims to determine the relation between the new environmental paradigm to responsible environmental behavior in high school students in Jakarta. The research was conducted at Jakarta State Senior High School 53 in the first semester of the 2017/2018 Academic Year. The method used is a survey method with correlational techniques. The sample used was 89 students of class XI MIA random sampling. Data was collected using new environmental paradigm instruments and responsible environmental behavior instruments. Data analysis was done by simple linear regression test to measure the magnitude of the relation using the Pearson Product Moment formula at the 5% significance level. The results of the study show that there is a positive and significant the relation between the new environmental paradigm to responsible environmental behavior. The correlation coefficient of this study is 0.276. The contribution of the new environmental paradigm variable to responsible environmental behavior variable is 7.6%. Therefore, the environmental paradigm has a role in improving student's responsible environmental behavior.
Keywords: new environmental paradigm, responsible environmental behavior, students.
Decadal Changes in Soil Organic Matter Due to Microaggregate and Hot Water Extractable Pools
Authors: Lambie Suzanne M. , Ghani Anwar , Mudge Paul L. , Stevenson Bryan A. 
Published: February 2019

Core Ideas
Hot water extractable and microaggregate C explained 60% of soil C change over time.
Hot water extractable and microaggregate N explained 47% of soil N change over time.
No significant soil order effects on changes in C and N in fractions.
Storage of C and N within aggregates is important for long‐term stabilization of soil organic matter (SOM). We investigated whether changes in C and N associated with physical soil fractions and the hot water extractable pool were correlated to changes in topsoil C and N over three decades. Archived soil samples from three soil orders collected from 46 sites across New Zealand were physically fractionated and the aggregate abundance (and C and N contents) of fractions determined; hot water extractable C (HWC) and hot water extractable N (HWN) were also measured. Together the change of C and N in hot water extractable SOM, microaggregate within macroaggregate, and free microaggregate fractions explained 60 and 47% of the change in whole soil C and N, respectively. Soil order was not a significant factor in the model suggesting that similar processes were operating in all three soil types. In summary, the development of strategies that enhance the storage of labile SOM and microaggregates could reverse the trend of loss of SOM and its associated ecosystems services.
A Test of Two Spatial Frameworks for Representing Spatial Patterns of Wetness in a Glacial Drift Watershed
Authors: Hofmeister K.L. , Nave L.E. , Riha S.J. , Schneider R.L. , Walter M.T. 
Published: February 2019

Core IdeasSoil moisture and water table position vary across ecosystems and parent materials.Ecosystem classifications and topographic wetness indices represent moisture status.Topographic wetness indices perform best in till rather than outwash soils.Including soil properties with topographic information improves moisture estimates.In forest ecosystems, soil water availability is an important indicator and driver of biogeochemical transformations, pedogenesis, and surface water–groundwater linkages. Given the importance of soil moisture and shallow groundwater to ecosystem processes, field measurements are critical. We investigated the spatial patterns and temporal dynamics of moisture conditions in a forested first‐order watershed in northern Michigan. We measured soil volumetric water content (VWC, %) and water table levels across a range of glacial parent materials and landforms. We also assessed the utility of using two different spatial frameworks (Landscape Ecosystem classification, Topographic Wetness Index) to represent spatial patterns of soil moisture and water table levels across the watershed. At the lowest landscape position (outwash‐lake plain swamp), saturation was perennial, with a median soil VWC of 53% and the water table 8 cm below ground surface. Among upland ecosystems, outwash landforms had consistently low VWC (16%) and showed no evidence of groundwater within 4 m of the surface; moraine ecosystems (till parent material) possessed mixed hydrologic conditions, with VWC ranging from 18 to 25% and water table levels 6 to 65 cm below the surface. In low‐variability dry or wet areas with relatively homogenous soils, larger ecosystem classification map units provide good representations of moisture conditions. In the more heterogeneous till soils, a finer‐scale spatial framework that accounts for local soil variation is optimal. A combination of both spatial frameworks is most appropriate for estimating moisture conditions in this glaciated landscape and can be used to identify biogeochemically important sites and to inform land management decisions.
Life, Movement, and Thought: Directions for Performance Philosophy and Practice as Research
Authors: Schultis Brian 
Published: February 2019

This essay addresses the common goals of but also the practical differences between the emerging fields of Performance Philosophy (PP) and Practice as Research (PaR). It does so by describing them both as interposing effective and affective action into the process of thinking and knowing, thereby resisting what Gilles Deleuze calls the Dogmatic Image of Thought. The dogmatic image is described as a directional movement based on Plato’s allegory of the cave, where those who would learn turn away from phenomenal becoming and move upward and outward towards eternal Truth. This movement travels from a static unknowing to a static knowledge. Both PP and PaR resist such movement by employing techniques which forestall arriving at either stasis. Through their developments, PP and PaR have come to concentrate on resisting one of these points of stasis or the other – with PP concentrating on avoiding static knowing, and PaR concentrating on finding the proper expression to avoid static unknowing, even while presenting its findings in forms that may appear ephemeral.
Thioredoxin, Glutathione and Related Molecules in Tumors of the Nervous System
Authors: Branco Vasco , Pimentel José , Brito Maria Alexandra , Carvalho Cristina 
Published: February 2019

Background:Central Nervous System (CNS) tumors have a poor survival prognosis due to their invasive and heterogeneous nature, in addition to the resistance to multiple treatments.Objective:In this paper, the main aspects of brain tumor biology and pathogenesis are reviewed both for primary tumors of the brain, (i.e., gliomas) and for metastasis from other malignant tumors, namely lung cancer, breast cancer and malignant melanoma which account for a high percentage of overall malignant brain tumors. We review the role of antioxidant systems, namely the thioredoxin and glutathione systems, in the genesis and/or progression of brain tumors.Methods:Although overexpression of Thioredoxin Reductase (TrxR) and Thioredoxin (Trx) is often linked to increased malignancy rate of brain tumors, and higher expression of Glutathione (GSH) and Glutathione S-Transferases (GST) are associated to resistance to therapy, several knowledge gaps still exist regarding for example, the role of Peroxiredoxins (Prx), and Glutaredoxins (Grx).Conclusion:Due to their central role in redox homeostasis and ROS scavenging, redox systems are potential targets for new antitumorals and examples of innovative therapeutics aiming at improving success rates in brain tumor treatment are discussed.
Ultrasound Assisted Synthesis of 3-(het)aryl Isocoumarin Derivatives and their in vitro Pharmacological Evaluation
Authors: Prasanna Gutta Lakshmi , Kumar Abbaraju V.D. Nagendra , Bharath Yarlagadda , Basaveswara Rao Mandava V. , Pal Manojit 
Published: February 2019

Background:
In view of numerous biological activities of 3-substituted isocoumarins a number
of analogues based on this scaffold were synthesized for their in vitro pharmacological evaluation.

Methods:
The syntheses of 3-substituted isocoumarins were carried out via a Pd/C-catalyzed Suzuki-
Miyaura coupling of 3-chloroisochromen-1-one with a range of boronic acid derivatives. This C-C bond
forming reaction was facilitated by ultrasound irradiation to afford the desired products in good yields. A
number of 3-(het)aryl isocoumarin derivatives were prepared by using this methodology and subsequently
tested for their TNF-α inhibitory properties in vitro followed by cytotoxicities via the MTT assay.

Results:
Several compounds showed inhibition of TNF-α with one compound showing an IC50 value
of 9.01±1.25 µM. Three compounds also showed promising cytotoxic properties against two cancer
cell lines with IC50 ~ 0.9-2.7 µM.

Conclusion:
The isocoumarin framework could be an effective template for the design and discovery
of new inhibitor of TNF-α for the potential treatment of related diseases.
Ameliorative Effect of Phosphodiesterase-5 Inhibitor in Rat Model of Vascular Dementia
Authors: Bhatia Pankaj , Singh Nirmal 
Published: February 2019

Introduction:Cerebral hypoperfusion has been considered as major risk factor for Vascular Dementia (VaD). The present study shows the potential of Tadalafil, a phosphodiesterase-5 inhibitor, in bilateral common carotid artery occlusion (BCCAo) induced VaD in rats.Materials and Methods:BCCAo procedure was performed under anesthesia in wistar rats to induce VaD. Morris Water-Maze (MWM) parameter was employed on 7th day post-surgery to determine learning and memory. Escape latency time, time spent in target quadrant, Path length and average swim speed taken as important parameters in MWM. Endothelial dysfunction was assessed in isolated aorta by observing endothelial dependent vasorelaxations and levels of serum nitrite. Various biochemical and histopathological estimations were also performed.Results:BCCAo produced significant impairment in endothelium dependent vasorelaxation and a decrease in serum nitrite levels indicating endothelial dysfunction. Further poor performance on MWM represents impairment of learning and memory. There was a significant rise in brain oxidative stress level (indicated by increase in brain thiobarbituric acid reactive species and decrease in reduced glutathione levels). Increase in brain acetylcholinesterase activity; brain myloperoxidase activity and brain neutrophil infiltration (as marker of inflammation) were also observed. Treatment of Tadalafil (5 & 10 mg/kg, p. o.)/Donepezil (0. 5 mg/kg, i.p., serving as standard) ameliorated BCCAo induced endothelial dysfunction; memory deficits; biochemical and histopathological changes in a significant manner.Conclusion:It may be concluded that Tadalafil has shown efficacy in rat model of BCCAo induced VaD and that phosphodiesterase-5 can be considered as an important therapeutic target for the treatment of VaD.
An iTRAQ Based Comparative Proteomic Profiling of ThermotolerantSaccharomyces cerevisiaeJRC6 in Response to High Temperature Fermentation
Authors: Choudhary Jairam , Singh Surender , Tiwari Rameshwar , Goel Renu , Nain Lata 
Published: February 2019

Background:Bioethanol derived from lignocellulosic biomass can supplement the ethanol supplies in a sustainable manner. However, the bioethanol production process is still not cost effective and researchers are looking for novel strategies like simultaneous saccharification fermentation to cut down the production cost. Thermotolerant yeast Saccharomyces cerevisiae JRC6 is reported to improve the fermentation efficiency under SSF. However, the mechanism of thermotolerance of the strain is unknown which is important for developing more robust yeast strains for simultaneous saccharification and fermentation.Objective:To identify proteomic changes responsible for imparting thermotolerance by iTRAQ based profiling of Saccharomyces cerevisiae JRC6 by growing at optimum (30°C) and high temperature (40°C). Methods: iTRAQ labeling followed by electrospray ionization based tandem mass spectrometry using SCIEX 5600 Triple-TOF Mass Spectrometer (MS).Methods:iTRAQ labeling followed by electrospray ionization based tandem mass spectrometry using SCIEX 5600 Triple-TOF Mass Spectrometer (MS).Results:A total of 582 proteins involved in heat shock, metabolism, biosynthesis, transport of biomolecules, cell division, etc. were identified. Cells grown at 40°C showed many-fold increase in the expression for many proteins involved in different functions specially biosynthesis, heat stress and metabolism. At 40°C heat shock proteins (78), prefoldin subunit (6), DNA binding protein SNT1, J type co-chaperone JAC1, elongation factor 1-β, glutathione synthase, malate synthase (2), purine biosynthesis protein ADE17, SSD1 protein, alcohol dehydrogenase 1, 3, 60S ribosomal protein L35-B, mitochondrial import protein MAS5 and many other proteins were significantly upregulated.Conclusion:The iTRAQ analysis revealed many heat shock proteins and heat stable alcohol dehydrogenases which can be exploited to develop a more robust yeast strain suitable for simultaneous saccharification and fermentation or consolidated bioprocessing.
Optimization of Crude Polysaccharides Extraction from Plantago ovata Forsk Seed by Response Surface Methodology
Authors: Sadeghi Ehsan , Mohammadi Reza , Shirgardoun Mohammad H. , Askari Fatemeh , Taghizadeh Masoumeh , Arjenaki Narges Omidi 
Published: February 2019

Background:Plantago ovata Forsk (Psyllium seed) is an annual plant of plantago genus. This plant widely grows in India and Iran. The Psyllium seed contains mucilage, protein, sugar, fat and tannins. Seed’s husk is a known source to extract hydrocolloid.Objective:The aim of this study was to optimize gum extraction from the Psyllium seed.Methods:The response surface methodology (RSM) was used to estimate the effect of independent variables on the extraction yield of Psyllium gum. The obtained experimental data were fitted to a second- order polynomial equation using multiple regression analysis and analyzed by appropriate statistical methods. A central composite design (CCD) was used for experimental design and analysis of the results to obtain the best possible combination of extraction temperature (X1= 60-80°C), extraction time (X2= 1-3 h), and the ratio of water to raw material (X3= 30-70%) for the maximum gum extraction.Results:Optimum extraction conditions were extraction temperature of 79°C, extraction time of 2.5 h, and the ratio of water to the raw material of 57%. The experimental extraction yield under optimal conditions was found to be 9 ± 0.25%, which was in agreement with the predicted value of 9.4%.Conclusion:This study showed that Psyllium gum can be used as a hydrocolloid source for pharmaceutical and food industry such as edible films for food packaging.
Computational Outlook of Marine Compounds as Anti-Cancer Representatives Targeting BCL-2 and Survivin
Authors: Shakeel Eram , Kumar Rajnish , Sharma Neha , Akhtar Salman , Ahmad Khan Mohd. Kalim , Lohani Mohtashim , Siddiqui Mohd. Haris 
Published: February 2019

<P>Introduction: The regulation of apoptosis via compounds originated from marine organisms signifies a new wave in the field of drug discovery. Marine organisms produce potent compounds as they hold the phenomenal diversity in chemical structures. The main focus of drug development is anticancer therapy.Methods:Expertise on manifold activities of compounds helps in the discovery of their derivatives for preclinical and clinical experiment that promotes improved activity of compounds for cancer patients.Results:These marine derived compounds stimulate apoptosis in cancer cells by targeting Bcl-2 and Survivin, highlighting the fact that instantaneous targeting of these proteins by novel derivatives results in efficacious and selective killing of cancer cells.Conclusion:Our study reports the identification of Aplysin and Haterumaimide J as Bcl-2 inhibitors and Cortistatin A as an inhibitor of survivin protein, from a sequential virtual screening approach.</P>
Single- and Multi-Step Image Enlargement for Medical Image Coding
Authors: Khosravi Mohammad Reza 
Published: February 2019

Background:
Some interpolators cannot be used in an image magnification problem in a freely scalable form.
For instance, when we want to magnify an image to a 16-time bigger scale, some interpolators have to do this process in
two steps including two 4-time magnification steps, however, some are able to do it directly.

Materials and Methods:
For generating data of this study, MATLAB as a simulator has been used. Bi-; Linear (BL) and
Cubic Convolution (CC) interpolators are the two applied re-samplers in the reconstruction of digital images.

Results:
Data shows that the performance of both free-size interpolators (BL and CC) is obviously different in both direct
and indirect pixel reconstruction.

Conclusion:
The acquired data shows a less error in the condition of direct interpolation. The relative results of experiments
are different from the type of core interpolators (BL and CC).
Analysis of Safety Outcomes in Chronic Hepatitis C Patients using Interferon-free Treatment: A Systematic Review of Case Reports
Authors: Ferreira Vinicius Lins , Leonart Leticia Paula , Rocca Ana Maria Della , Pontarolo Roberto 
Published: February 2019

Background:Second generation direct acting-antivirals are safe and effective treatments for chronic hepatitis C patients.Objective:We aimed to conduct a systematic review of case reports and case series to evaluate the safety of the drugs, highlighting a compilation of AE not previously reported in other reviews.Methods:The search was performed in four electronic databases and included only case reports and case series that evaluated interferon-free therapies and provided safety outcomes.Results:Initially 1,235 records were retrieved, and after screening 30 studies were included in the analysis (23 case reports and 7 case series). A total of 39 patients were included, receiving eight different interferon-free treatments. Nineteen patients discontinued treatment (only 8 of these achieved treatment response). Other 19 patients achieved SVR without discontinuation. Rare adverse events were observed, including breast hypertrophy, retinopathy and drug-induced infection. Some patients were in an advanced stage of the disease, and were therefore unable to withstand treatment due to the appearance of complications.Conclusion:In this sense, it is important to monitor the use of these drugs that can favor the appearance of serious AE. (PROSPERO registration number CRD42016051680).
Effect of a Physical Activity Program on Serum Biochemical Parameters among the Elderly Women
Authors: Motalebi Seyedeh Ameneh , Iranagh Jamileh Amirzadeh , Mohammadi Fatemeh 
Published: February 2019

Background:
The present study examined the efficacy of the walking program on biochemical
parameters among the elderly women.

Methods:
A total of one hundred elderly women participated in this randomized clinical trial study.
The intervention group attended a 24-week walking exercise meeting five times per week. The control
group continued with their routine activities. The subjects were assessed in Fasting blood glucose
(FBS) and lipid profile before and after 12 and 24 weeks of the program.

Results:
The mean age of the elderly participants in the study was 68.33 ± 4.55 years. The results of
repeated measures ANOVA showed a significant difference between the intervention and the control
group in FBS, total cholesterol, triglyceride, high-density lipoprotein cholesterol, and low-density
lipoprotein cholesterol after completing the program (for all p < 0.001).

Conclusion:
The low-cost physical activity intervention could be effective for reducing chronic vascular
disease risk factors among community-dwelling elderly women.
Antimicrobial Resistance and Presence of Class 1 Integrons Among Different Serotypes of Salmonella spp. Recovered From Children with Diarrhea in Tehran, Iran
Authors: Eshaghi Zadeh Seyedeh Hanieh , Fahimi Hossein , Fardsanei Fatemeh , Soltan Dallal Mohammad Mehdi 
Published: February 2019

Background:
Salmonellosis is a major food-borne disease worldwide. The increasing
prevalence of antimicrobial resistance among food-borne pathogens such as Salmonella spp. is
concerning.

Objective:
The main objective of this study is to identify class 1 integron genes and to determine
antibiotic resistance patterns among Salmonella isolates from children with diarrhea.

Methods:
A total of 30 Salmonella isolates were recovered from children with diarrhea. The isolates
were characterized for antimicrobial susceptibility and screened for the presence of class 1
integron genes (i.e. intI1, sulI1, and qacEΔ1).

Results:
The most prevalent serotype was Enteritidis 36.7%, followed by Paratyphi C (30%), and
Typhimurium (16.7%). The highest rates of antibiotic resistance were obtained for nalidixic acid
(53.3%), followed by streptomycin (40%), and tetracycline (36.7%). Regarding class 1 integrons,
36.7%, 26.7%, and 33.3% of the isolates carried intI1, SulI, and qacEΔ1, respectively, most of
which (81.8%) were multidrug-resistant (MDR). Statistical analysis revealed that the presence of
class 1 integron was significantly associated with resistance to streptomycin and tetracycline (p =
0.042). However, there was no association between class 1 integron and other antibiotics used in
this study (p > 0.05).

Conclusion:
The high frequency of integron class 1 gene in MDR Salmonella strains indicates
that these mobile genetic elements are versatile among different Salmonella serotypes, and associated
with reduced susceptibility to many antimicrobials.