bluuebunny/crossref_metadata_2025_split huggingface dataset:
Static output feedback control for discrete‐time hidden Markov jump systems against deception attacks
Authors: Su Lei , Ye Dan 
Published: September 2019

SummaryThis paper investigates the static output feedback control problem for Markov jump systems subject to asynchronous mode information and deception attacks. A hidden Markov model is employed to observe the unmeasurable system mode. In this case, the asynchronous phenomenon between the controller and the original system is depicted. By using the mode‐dependent Lyapunov function, a sufficient condition is established such that the resulting closed‐loop system is stochastically mean square exponentially ultimately bounded under randomly occurring deception attacks and external disturbance. Based on this condition, the asynchronous static output feedback controller is designed in view of linear matrix inequalities. Finally, the effectiveness and superiority of the presented method are elaborated via a numerical example and a practical example.
SO3Cu‐Carbon: A Novel Heterogeneous Catalyst for the Synthesis of β‐Hydroxy 1,2,3‐Triazoles by One Pot Cycloaddition Reaction
Authors: Rani G. Sandhya , Vijay Manneganti , Prabhavathi Devi Bethala L. A. 
Published: September 2019

AbstractA novel heterogeneous carbon‐based sulfonated copper (SO3Cu‐carbon) catalyst was developed for the first time and investigated its catalytic activity for the regioselective synthesis of β‐hydroxy 1,2,3‐triazoles by azide–alkyne cycloaddition in aqueous medium. The SO3Cu‐carbon catalyst was prepared by the modification of the glycerol‐based SO3H‐carbon catalyst on treatment with 10% aqueous CuCl2 solution under controlled conditions. Based on its physico‐chemical characteristics the structure of the catalyst is proposed as a polycyclic aromatic carbon attached with ‐SO3Cu, ‐COOCu and –OCu functionalities. The catalytic activity of the SO3Cu‐carbon catalyst was demonstrated for the one pot ‘click’ reaction of epoxide, sodium azide and terminal alkyne in water at 60 °C for the synthesis of β‐hydroxy 1,2,3‐triazoles in excellent yields (89‐94%) without any additives. The formation of the product proceeds in one pot through a mechanism that involves in situ generation of organic azide intermediate followed by rapid ring closure with alkynes. The catalyst was easily recovered by simple filtration and reused for 5 cycles without any leaching and deactivation thus exhibiting its excellent stability and reusability. Moreover, the cascade reaction was best performed in water at moderate temperature, rendering all the processes truly green.
Planar Anchoring of C70 Liquid Crystals Using a Covalent Organic Framework Template
Authors: Cui Daling , MacLeod Jennifer M. , Rosei Federico 
Published: September 2019

AbstractThe surface‐induced anchoring effect is a well‐developed technique to control the growth of liquid crystals (LCs). Nevertheless, a defined nanometer‐scale template has never been used to induce the anchored growth of LCs with molecular building units. Scanning tunneling microscopy results at the solid/liquid interface reveal that a 2D covalent organic framework (COF‐1) can offer an anchoring effect to template C70 molecules into forming several LC mesophases, which cannot be obtained under other conditions. Through comparison with the C60 system, a stepwise breakdown in ordering of C70 LC is observed. The process is described in terms of the effects of molecular anisotropy on the epitaxial growth of molecular crystals. The results suggest that using a surface‐confined template to anchor the initial layer of LC molecules can be a modular and potentially broadly applicable approach for organizing molecular mesogens into LCs.
Surface Plasmon Resonance–Enhanced Photoacoustic Imaging and Photothermal Therapy of Endogenous H2S‐Triggered Au@Cu2O
Authors: Tao Cheng , An Lu , Lin Jiaomin , Tian Qiwei , Yang Shiping 
Published: September 2019

AbstractSmart theranostics agents triggered by endogenous H2S with combined activated photoacoustic imaging and photothermal therapy can improve the diagnosis and treatment of colon cancer. However, the low theranostic performance of the current smart theranostics agents after the triggering step has limited their further application. In this work, the theranostic performance of endogenous H2S‐triggered Au@Cu2O for the diagnosis and treatment of colon cancer, which is generated from the localized surface plasmon resonance coupling effect between a noble metal (Au) and a semiconductor (Cu2O), is investigated. Compared with Cu2O, the prepared H2S‐triggered Au@Cu2O shows a significantly stronger absorption at the near‐infrared region, such as a ≈2.1 times change at 808 nm, giving a photothermal conversion efficiency increase of ≈1.2 times. More importantly, Au@Cu2O still exhibits good photoacoustic imaging contrast and photothermal properties for treatment of colon cancer in vivo even at very low injection doses. This work not only investigates an endogenous H2S‐triggered Au@Cu2O theranostic agent with enhanced theranostic performance for colon cancer but also provides a novel strategy for designing high‐performance theranostic agents.
Defect‐Enriched Nitrogen Doped–Graphene Quantum Dots Engineered NiCo2S4 Nanoarray as High‐Efficiency Bifunctional Catalyst for Flexible Zn‐Air Battery
Authors: Liu Wenwen , Ren Bohua , Zhang Wenyao , Zhang Maiwen , Li Gaoran , Xiao Meiling , Zhu Jianbing , Yu Aiping , Ricardez‐Sandoval Luis , Chen Zhongwei 
Published: September 2019

AbstractFlexible Zn‐air batteries have recently emerged as one of the key energy storage systems of wearable/portable electronic devices, drawing enormous attention due to the high theoretical energy density, flat working voltage, low cost, and excellent safety. However, the majority of the previously reported flexible Zn‐air batteries encounter problems such as sluggish oxygen reaction kinetics, inferior long‐term durability, and poor flexibility induced by the rigid nature of the air cathode, all of which severely hinder their practical applications. Herein, a defect‐enriched nitrogen doped–graphene quantum dots (N‐GQDs) engineered 3D NiCo2S4 nanoarray is developed by a facile chemical sulfuration and subsequent electrophoretic deposition process. The as‐fabricated N‐GQDs/NiCo2S4 nanoarray grown on carbon cloth as a flexible air cathode exhibits superior electrocatalytic activities toward both oxygen reduction reaction (ORR) and oxygen evolution reaction (OER), outstanding cycle stability (200 h at 20 mA cm−2), and excellent mechanical flexibility (without observable decay under various bending angles). These impressive enhancements in electrocatalytic performance are mainly attributed to bifunctional active sites within the N‐GQDs/NiCo2S4 catalyst and synergistic coupling effects between N‐GQDs and NiCo2S4. Density functional theory analysis further reveals that stronger OOH* dissociation adsorption at the interface between N‐GQDs and NiCo2S4 lowers the overpotential of both ORR and OER.
Creation of Nonspherical Microparticles through Osmosis‐Driven Arrested Coalescence of Microfluidic Emulsions
Authors: Feng Kai , Gao Ning , Zhang Wanlin , Zhou Kang , Dong Hao , Wang Peng , Tian Li , He Guokang , Li Guangtao 
Published: September 2019

AbstractDroplet‐based microfluidics enable the production of emulsions and microparticles with spherical shapes, but the high‐throughput fabrication of nonspherical emulsions and microparticles still remains challenging because interfacial tension plays a dominant role during preparation. Herein, ionic liquids (ILs) containing salts, which possess sufficient osmotic pressure to realize water transport and phase separation, are introduced as inner cores of oil‐in‐oil‐in‐water double emulsions and it is shown that nonspherical emulsions can be constructed by osmosis‐driven arrested coalescence of inner cores. Subsequently, ultraviolet polymerization of the nonspherical emulsions leads to nonspherical microparticles. By tailoring the number, composition, and size of inner cores as well as coalescence time, a variety of nonspherical shapes such as dumbbell, rod, spindle, snowman, tumbler, three‐pointed star, triangle, and scalene triangle are created. Importantly, benefitting from excellent solvency of ILs, this system can serve as a general platform to produce nonspherical microparticles made from different materials. Moreover, by controlling the osmotic pressure, programmed coalescence of inner cores in double emulsions is realizable, which indicates the potential to build microreactors. Thus, a simple and high‐throughput strategy to create nonspherical microparticles with arrested coalescence shapes is developed for the first time and can be further used to construct novel materials and microreactors.
Effects of Multiple Nonnative Fish on an Imperiled Cyprinid, Hornyhead Chub
Authors: Hickerson Brian T. , Maitland Bryan M. , Walters Annika W. 
Published: September 2019

AbstractNonnative fish can have substantial negative effects on the abundance and distribution of native fishes through predation and competition. Nonnative predators are of particular interest because they represent novel threats to native prey species that are not adapted to their presence. Prey species with limited distributions or population sizes may be particularly vulnerable to the effects of nonnative predators. In the Laramie River, four nonnative predators—Brown TroutSalmo trutta, Rainbow TroutOncorhynchus mykiss, Brook TroutSalvelinus fontinalis,and Smallmouth BassMicropterus dolomieuare present along with a state‐imperiled population of Hornyhead ChubNocomis biguttatus. The abundance of Hornyhead Chub has declined with increasing abundance of nonnative predators, with the probability of occurrence of Hornyhead Chub dropping drastically when Smallmouth Bass were present. All four nonnative species preyed on native cyprinids, but Smallmouth Bass relied most heavily on fish as a prey item. Isotopic niche overlap occurred between Hornyhead Chub and all of the nonnative predator species. Our results demonstrate that nonnative predators have the potential to negatively affect the abundance and distribution of Hornyhead Chub through the mechanisms of predation and competition, and predator identity is important in determining the extent of effects. Smallmouth Bass are a greater concern than nonnative salmonids because of their more piscivorous behavior, and their recent upstream expansion may be limiting the downstream distribution of Hornyhead Chub in the Laramie River.
Survey methodology for detecting eastern massasauga rattlesnakes in southern Michigan
Authors: Shaffer Stephanie A. , Roloff Gary J. , Campa Henry 
Published: September 2019

ABSTRACTThe U.S. Fish and Wildlife Service listed the eastern massasauga rattlesnake (Sistrurus catenatus catenatus) as threatened in 2016 under the 1973 Endangered Species Act. We tested a visual‐encounter survey method during 2016 to aid researchers and managers in successfully detecting massasaugas in occupied habitat in southern Michigan, USA. We conducted 54 surveys (paired, independent searchers) in 2‐ha areas occupied by telemetered massasaugas. Our detection process parameters included environmental conditions (air temperature, humidity, solar radiation, surface temperature, precipitation) and searcher characteristics (e.g., experience, time spent searching). We detected massasaugas on 11 of 54 surveys. Detection probability from the null model was 0.31; however, we found that time spent searching and minimum air temperature improved detection probability. Detection probability approached 1.00 as time searched by an individual exceeded 90 minutes and approached 0.80 on cooler mornings (12.8° C). Our findings provide survey protocol guidance to increase massasauga detections during visual encounter surveys, which offer useful information to help guide habitat management decisions. © 2019 The Wildlife Society.
Induced pluripotent stem cell macrophages present antigen to proinsulin-specific T cell receptors from donor-matched islet-infiltrating T cells in type 1 diabetes
Authors: Joshi Kriti , Elso Colleen , Motazedian Ali , Labonne Tanya , Schiesser Jacqueline V. , Cameron Fergus , Mannering Stuart I. , Elefanty Andrew G. , Stanley Edouard G. 
Published: September 2019

Abstract

Aims/hypothesis
Type 1 diabetes is an autoimmune disorder characterised by loss of insulin-producing beta cells of the pancreas. Progress in understanding the cellular and molecular mechanisms underlying the human disease has been hampered by a dearth of appropriate human experimental models. We previously reported the characterisation of islet-infiltrating CD4+ T cells from a deceased organ donor who had type 1 diabetes.

Methods
Induced pluripotent stem cell (iPSC) lines derived from the above donor were differentiated into CD14+ macrophages and tested for their capacity to present antigen to T cell receptors (TCRs) derived from islet-infiltrating CD4+ T cells from the same donor.

Results
The iPSC macrophages displayed typical macrophage morphology, surface markers (CD14, CD86, CD16 and CD11b) and were phagocytic. In response to IFNγ treatment, iPSC macrophages upregulated expression of HLA class II, a characteristic that correlated with their capacity to present epitopes derived from proinsulin C-peptide to a T cell line expressing TCRs derived from islet-infiltrating CD4+ T cells of the original donor. T cell activation was specifically blocked by anti-HLA-DQ antibodies but not by antibodies directed against HLA-DR.

Conclusions/interpretation
This study provides a proof of principle for the use of iPSC-derived immune cells for modelling key cellular interactions in human type 1 diabetes.
Adhesive-related warping of thin wooden bi-layers
Authors: Rindler Axel , Vay Oliver , Hansmann Christian , Konnerth Johannes 
Published: September 2019

Abstract
Warping of layered wood-based panels is still a challenging problem in the development of thin engineered wood products. Wood as an anisotropic and hydrophilic material tends to change its volume and mechanical properties with changing moisture content. Besides the wood components, also the mechanical properties of certain adhesives are sensitive to moisture changes. A moisture load onto the adhered wood is resulting in different stress and strain states between the adherends. It is expected that adhesives with different moisture-related properties participate differently to this interaction. To observe an adhesive-related warping, thin spruce/HDF (Picea abies and high-density fibreboard) bi-layers with identical material geometries were manufactured under laboratory conditions, using different wood adhesive systems, which are currently used in furniture and flooring industry [polyurethane (PUR), emulsion polymer isocyanate (EPI), polyvinyl acetate (PVAc), urea formaldehyde (UF) and ultra-low emitting formaldehyde amino adhesive (ULEF)]. The bi-layers were exposed to certain relative humidity conditions, and the resulting deformation was measured with a high-precision laser distance detector. Moisture-dependent warping of the bi-layers was obtained in relation to the used adhesive systems. As a result of the study, it can be shown that initial warping after panel manufacturing strongly depends on the adhesive curing characteristics and, especially, on the amount of water that is released into the wood adherend. For the post-setting panel warping, a differentiation into two adhesive groups became visible: rigid and flexible adhesives. Rigid adhesives (UF and ULEF) showed a higher degree of warping compared to the group of flexible adhesives (PUR, EPI and PVAc).
A prospective phase I multicentre randomized cross-over pharmacokinetic study to determine the effect of food on abiraterone pharmacokinetics
Authors: Lubberman Floor J. E. , Benoist Guillemette E. , Gerritsen Winald , Burger David M. , Mehra Niven , Hamberg Paul , van Oort Inge , van Erp Nielka P. 
Published: September 2019

Abstract

Purpose
Abiraterone acetate is used at a fixed oral dose of 1000 mg once daily (OD) taken fasted. By administering abiraterone acetate with food, a reduced dose can potentially be given while maintaining equivalent abiraterone exposure. Moreover, administering abiraterone acetate with a breakfast is considered more patient friendly. The aim of this study was to establish the bio-equivalent lower dose of abiraterone when taken with a continental breakfast (CB) compared to the standard intake of 1000 mg OD fasted.

Methods
In this phase I, randomized cross-over, multi-center study, abiraterone pharmacokinetics (PK) were evaluated in patients with metastatic castration-resistant prostate cancer who were treated for 14 days with 1000 mg abiraterone acetate taken fasted, followed by 14 days of treatment with 500 mg taken with a CB.

Results
14 patients were enrolled into the study, of whom 12 were eligible for PK analysis. The geometric mean ratio (GMR) (fed/fasted) was 0.88 (90% CI 0.73–1.07) for area-under-the-curve (AUC0–24h), 1.03 (90% CI 0.79–1.34) for Cmax and 0.81 (90% CI 0.60–1.10) for Ctrough, respectively. High inter-patient variability (> 50%) was found for all PK parameters under both intake conditions. Patients seemed to be slightly more satisfied about the intake of 500 mg abiraterone acetate when taken with a CB compared to 1000 mg fasted.

Conclusion
In conclusion, a bioequivalent lower dose of abiraterone taken with food could not be established in our study. Although based on the absence of a exposure–toxicity relationship, the strict bioequivalence margins as defined by the FDA guidelines could be applied more flexible for abiraterone. Information on the effect of food on abiraterone pharmacokinetics as presented in our study can be used for patients with difficulties taken their medication fasted.
Hyposmia as a marker of (non-)motor disease severity in Parkinson’s disease
Authors: Roos Dareia S. , Twisk Jos W. R. , Raijmakers Pieter G. H. M. , Doty Richard L. , Berendse Henk W. 
Published: September 2019

Abstract
The aim of this study was to evaluate the relationship of hyposmia in Parkinson’s disease (PD) with other motor and non-motor symptoms and with the degree of nigrostriatal dopaminergic cell loss. A total of 295 patients with a diagnosis of PD were included. Olfactory function was measured using the University of Pennsylvania Smell Identification Test (UPSIT). Motor symptoms were rated using the Unified Parkinson’s Disease Rating Scale motor subscale (UPDRS III). To evaluate other non-motor symptoms, we used the Mini-Mental State Examination (MMSE) as a measure of global cognitive function and validated questionnaires to assess sleep disturbances, psychiatric symptoms, and autonomic dysfunction. A linear regression model was used to calculate correlation coefficients between UPSIT score and motor and non-motor variables [for psychiatric symptoms a Poisson regression was performed]. In a subgroup of patients (n = 155) with a dopamine transporter (DaT) SPECT scan, a similar statistical analysis was performed, now including striatal DaT binding. In the regression models with correction for age, sex, disease duration, and multiple testing, all motor and non-motor symptoms were associated with UPSIT scores. In the subgroup of patients with a DaT-SPECT scan, there was a strong association between olfactory test scores and DaT binding in both putamen and caudate nucleus. Hyposmia in PD is associated with various motor and non-motor symptoms, like cognition, depression, anxiety, autonomic dysfunction and sleep disturbances, and with the degree of nigrostriatal dopaminergic cell loss. This finding adds further confirmation that hyposmia holds significant promise as a marker of disease progression.
Microstructural and histochemical analysis of aboveground organs of Centaurea cyanus used in herbal medicine
Authors: Haratym Weronika , Weryszko-Chmielewska Elżbieta , Konarska Agata 
Published: September 2019

Abstract
Centaurea cyanus L. is a valuable source of many different bioactive substances. It is used in herbal medicine, but the structure of its organs used as raw material and secretory tissues has been insufficiently examined. The aim of this paper was to investigate the microstructure of C. cyanus flowers, bracts, stems and leaves with particular emphasis on secretory structures. Moreover, the main classes of secondary metabolites present in the secretion were identified and the taxonomic value of some micromorphological and anatomical features was analysed. Histochemical, micromorphological and ultrastructural analyses of aboveground organs of C. cyanus were carried out using light, fluorescence, scanning and transmission electron microscopy. The analyses revealed the presence of petal papillae and a characteristic cuticular pattern on the petals, stamens and stylar hairs. There were four types of non-glandular trichomes on the bracts, leaves and stem surfaces. The epidermal cells of the bracts contained prismatic calcium oxalate crystals. Two kinds of secretory structures, i.e. glandular trichomes and ducts, were observed in the C. cyanus organs. The glandular trichomes were located on the bract and stem surfaces, and the ducts were detected in the leaves and stems. Ultrastructural analyses of the epithelium of the ducts showed the presence of strongly osmiophilic insoluble phenolic material in vacuoles as well as moderately osmiophilic insoluble lipidic material in elaioplasts and vesicles. The results of histochemical assays showed a heterogeneous nature of the duct secretion, which contained essential oil, lipids, flavonoids, tannins and terpenes containing steroids.
Performance of polarization-consistent vs. correlation-consistent basis sets for CCSD(T) prediction of water dimer interaction energy
Authors: Kupka Teobald , Buczek Aneta , Broda Małgorzata A. , Mnich Adrianna , Kar Tapas 
Published: September 2019

Abstract
Detailed study of Jensen’s polarization-consistent vs. Dunning’s correlation-consistent basis set families performance on the extrapolation of raw and counterpoise-corrected interaction energies of water dimer using coupled cluster with single, double, and perturbative correction for connected triple excitations (CCSD(T)) in the complete basis set (CBS) limit are reported. Both 3-parameter exponential and 2-parameter inverse-power fits vs. the cardinal number of basis set, as well as the number of basis functions were analyzed and compared with one of the most extensive CCSD(T) results reported recently. The obtained results for both Jensen- and Dunning-type basis sets underestimate raw interaction energy by less than 0.136 kcal/mol with respect to the reference value of − 4.98065 kcal/mol. The use of counterpoise correction further improves (closer to the reference value) interaction energy. Asymptotic convergence of 3-parameter fitted interaction energy with respect to both cardinal number of basis set and the number of basis functions are closer to the reference value at the CBS limit than other fitting approaches considered here. Separate fits of Hartree-Fock and correlation interaction energy with 3-parameter formula additionally improved the results, and the smallest CBS deviation from the reference value is about 0.001 kcal/mol (underestimated) for CCSD(T)/aug-cc-pVXZ calculations. However, Jensen’s basis set underestimates such value to 0.012 kcal/mol. No improvement was observed for using the number of basis functions instead of cardinal number for fitting.