bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effectiveness of Insulin Degludec in Thai Patients with Diabetes Mellitus: Real-World Evidence From a Specialized Diabetes Center
Authors: Thewjitcharoen Yotsapon , Yenseung Nalin , Malidaeng Areeya , Butadej Siriwan , Chotwanvirat Phawinpon , Krittiyawong Sirinate , Thammawiwat Chattip , Himathongkam Thep 
Published: October 2019

Abstract
Background Insulin degludec, an ultra-long-acting insulin analogue, has been available in Thailand since October 2016. Although clinical trial results revealed less hypoglycemia, data from real-world settings is limited especially in Asian patients. This study aimed to evaluate prospectively the real-world effectiveness, safety, quality of life (QOL) and patient satisfaction with insulin degludec among Thai patients with diabetes mellitus (DM).
Methods From October 2016 to September 2017, all patients who had started insulin degludec for at least 3 months were observed and evaluated at baseline, 3, 6, and 12 months. QOL was assessed using WHOQOL-BREF-THAI and level of satisfaction was measured by 7-point Likert scale. Glycemic fluctuation from paired iPro2 continuous glucose monitoring (CGM) obtained 4–6 weeks apart were also evaluated from a subset of patients with T1DM who switched from insulin glargine to insulin degludec.
Results A total of 55 patients (T2DM 76.4%, females 54.5%, mean age 57.1±16.1 years, duration of diabetes 16.7±8.8 years, BMI 27.3±5.5 kg/m2, baseline A1C 9.3±2.3%, median duration of treatment 8 months) were included in the study. In T1DM patients (n=13), the overall mean A1C reduction at 12 months was 0.5% with minimal weight gain of 0.9 kgs at 12 months. In T2DM patients (n=42), the overall mean A1C reduction at 12 months was 0.8% with minimal weight loss of 0.4 kgs at 12 months. The proportion of T1DM patients who could achieve optimal glycemic control increased slightly from 14.3 to 18.2% but the proportion of T2DM patients who could achieve optimal glycemic control increased from 30.8 to 53.8%. Patient satisfaction showed a sustained improvement throughout the duration of study. In four T1DM patients who had paired CGM data, insulin degludec provided greater reductions in glycemic variability endpoints with increased time-in-range when compared with previous insulin glargine.
Discussion Our data suggested that the effectiveness of insulin degludec was consistent with the results seen in clinical trials with lower risk of patients-reported hypoglycemia, and a significant improvement in glycemic control. Patients also reported higher treatment satisfaction. More long-term and cost-effectiveness data are needed to establish the role of this ultra-long-acting insulin in real-world settings.
New Perspectives for Modern Trauma Management – Lessons Learned from 25 Years FAST and 15 Years E-FAST
Authors: Osterwalder Joseph , Mathis Gebhard , Hoffmann Beatrice 
Published: October 2019

AbstractE-FAST (Extended-Focused Assessment with Sonography for Trauma) is now a widely utilized and internationally recognized standard exam in trauma care. It is highly accepted by emergency physicians and trauma surgeons alike. Thanks to the popularity of PoCUS (point-of-care ultrasound), it has continued to evolve over the last years and can now improve trauma diagnosis at all stages of the primary ABCDE. This review article summarizes key observations made over recent years and also highlights the extension of FAST into E-FAST in the context of PoCUS and CT developments for modern trauma management. Time has come to learn the lessons from 25 years of FAST and 15 years of E-FAST. We should redefine and position ultrasound in the primary ATLS survey (Advanced Trauma Life Support) on two levels: 1. Basic ATLS with new clinical questions, six additional abdominal image sections and one or more follow-up examinations depending on the clinical situation, and 2. Advanced ATLS with ultrasound applications for the entire trauma ABCDE.
Rheumatoide Arthritis und Unfallbegutachtung
Authors: Biehl Christoph , Rupp Markus , Schiefer Urs , Thaqif El Khassawna , Heiß Christian 
Published: October 2019

ZUSAMMENFASSUNGDank verbesserter Diagnostik und medikamentöser Therapie sind mehr Rheumapatienten berufstätig und dadurch auch in größerem Ausmaß von Berufs- und Wegeunfällen betroffen als noch vor einigen Jahren. Zur Abklärung der durch den Unfall verursachten Schädigung muss eine gutachterliche Prüfung auf Kausalität erfolgen. Durch eine inflammatorische Grunderkrankung hervorgerufene Veränderungen müssen als Mitursache einzeln geprüft und abgewogen werden. Das Wissen um die Beeinflussung systemischer Regelkreise und deren Auswirkungen auf ein mögliches Trauma sind für mit Gutachten Betraute eminent.
Auftragen, baden, essen
Authors: Bierbach Elvira 
Published: October 2019

SummaryHeilerden sind Peloide: Gesteinsgemische mit organischen und/oder mineralischen Anteilen, die entweder schon von Natur aus feinkörnig sind oder zerkleinert werden. Heilerden wirken vor allem über die enthaltenen Mineralstoffe und Spurenelemente sowie ihre Fähigkeit, Substanzen zu binden, Wärme zu speichern und nutzbringend abzugeben. Zu den häufig angewandten Heilerden gehören Lehm, Löss, Grüne Mineralerde, Fango, Moor und Torf sowie Schlick.
Brustkrebs beim Mann – die Sicht der beteiligten
Berufsgruppen auf die multiprofessionelle Versorgung einer seltenen
Erkrankung
Authors: Ernstmann Nicole , Midding Evamarie , Halbach Sarah , Würstlein Rachel , Weber Rainer , Christmann Sherin , Kowalski Christoph 
Published: October 2019

Zusammenfassung
Ziel der Studie Brustkrebs beim Mann ist eine seltene Erkrankung,
für die jedoch hochspezialisierte Versorgungsstrukturen zur Therapie des
Brustkrebses der Frau zur Verfügung stehen. Bislang ist unbekannt, ob
die Ausrichtung der Versorgungsstrukturen auf Frauen zu Defiziten in der
Versorgung der betroffenen Männer führt. Daher ist es das Ziel
der vorliegenden Untersuchung, mögliche Versorgungsdefizite aus der
Perspektive der beteiligten Professionen zu identifizieren.
Methodik Es wurden teilstandardisierte Leitfadeninterviews mit
n=23 Teilnehmer/innen sowie 2 Fokusgruppendiskussionen mit
n=7 bzw. n=9 Teilnehmer/innen durchgeführt. Die
Transkripte der Interviews und Fokusgruppendiskussionen wurden mittels
qualitativer Inhaltsanalyse mit MAXQDA ausgewertet.
Ergebnisse Einige Teilnehmer/innen sehen aufgrund des
Erfahrungsmangels eigene Unsicherheiten in der Versorgung von Männern
mit Brustkrebs. Häufig wird ein mangelndes Wissen bezüglich der
Zuständigkeiten und Behandlungsmöglichkeiten, z. B. bei
niedergelassenen Gynäkolog/innen, beklagt. Viele Befragte
empfinden eine mangelnde interdisziplinäre Zusammenarbeit, v. a. in der
Nachsorge. Einige Befragte sehen darüber hinaus einen Mangel an
spezialisierten Rehabilitationseinrichtungen für Männer mit
Brustkrebs.
Schlussfolgerung Männer mit Brustkrebs profitieren trotz der
Seltenheit der Erkrankung von den hochentwickelten Strukturen zur
Brustkrebsversorgung in Deutschland. Dennoch zeigen sich Versorgungsdefizite aus
der Sicht der behandelnden Professionen. Diese Datengrundlage kann in
Kombination mit der Perspektive der Betroffenen und weiteren
repräsentativen Daten dazu dienen, Praxis-Empfehlungen zur Verbesserung
der Versorgungsqualität des männlichen Brustkrebses zu
erarbeiten.
Lesbarkeit von Informationsmaterial in der
Geburtshilfe
Authors: Tegethoff Dorothea 
Published: October 2019

ZusammenfassungZeitgemäße Gesundheitsversorgung setzt voraus, dass die
Betroffenen autonome Entscheidungen über diagnostische und
therapeutische Maßnahmen treffen (Informed consent). Damit
Patient/innen Eingriffe und ihre Konsequenzen verstehen, muss
verständliches Informationsmaterial zur Verfügung stehen. Mit
verschiedenen Messinstrumenten (G-SMOG, Flesch-Index, Amstad-Formel, LIX) wurden
Aufklärungsbögen zum Kaiserschnitt, geburtshilflichen
Maßnahmen und Anästhesieverfahren auf ihre Lesbarkeit
untersucht. Als Vergleichsmaterial wurden leicht auffindbare Texte aus dem
Internet und anderes Informationsmaterial zum Thema Kaiserschnitt und
Anästhesieverfahren in der Geburtshilfe herangezogen. Die
Messinstrumente, die für die deutsche Sprache entwickelt wurden,
erwiesen sich als nützlich für das Screening der
Leseschwierigkeit. Es zeigt sich zudem, dass ein großer Teil der
untersuchten Texte schwierig oder sehr schwierig lesbar ist. Insbesondere die
Aufklärungsbögen liegen deutlich über den für
die Allgemeinbevölkerung lesbaren Werten. Es sollten erhebliche
Anstrengungen unternommen werden, um z. B. orientiert am
„Hamburger Verständlichkeitsmodell“ gut lesbare und
verständliche Informationsmaterialien zu erarbeiten.
Anesthesia Concerns in Child with Takayasu Arteritis for Catheterization Laboratory Intervention
Authors: Irpachi Kalpana , Sharan Sandeep , Karanjkar Ameya , Kapoor Poonam Malhotra 
Published: October 2019

AbstractTakayasu’s arteritis (pulse less disease) is a nonspecific chronic progressive panendarteritis affecting the large- and medium-sized arteries, involving the aorta and its main branches. Anesthesia for patients with Takayasu’s arteritis complicated by severe uncontrolled hypertension, end-organ dysfunction, stenosis of major blood vessels, and difficulties encountered in monitoring arterial blood pressure. We describe the anesthetic concerns of a child with Takayasu’s arteritis and severe hypertension refractory to medical treatment, presented with bilateral renal artery stenosis requiring urgent bilateral percutaneous renal angioplasty.
Sports-Related Pediatric Facial Trauma: Analysis of Facial Fracture Pattern and Concomitant Injuries
Authors: Dobitsch Andrew A. , Oleck Nicholas C. , Liu Farrah C. , Halsey Jordan N. , Hoppe Ian C. , Lee Edward S. , Granick Mark S. 
Published: October 2019

Abstract
Objective Sports-related injuries, such as facial fractures, are potentially debilitating and may lead to long-term functional and aesthetic deficits in a pediatric patient. In this study, we analyze sports-related facial fractures in the urban pediatric population in an effort to characterize patterns of injury and improve management strategies and outcomes.
Methods Retrospective chart review was performed for all facial fractures resulting from sports injuries in the pediatric population at a level-1 trauma center (University Hospital, Newark, NJ).
Results Seventeen pediatric patients were identified as having sustained a fracture of the facial skeleton due to sports injury. Mean age was 13.9 years old. A total of 29 fractures were identified. Most common fracture sites included the orbit (n = 12), mandible (n = 5), nasal bone (n = 5), and zygomaticomaxillary complex (n = 3). The most common concomitant injuries included skull fracture (n = 3), intracranial hemorrhage (n = 4), and traumatic brain injury (n = 4). One patient was intubated upon arrival to the emergency department. Hospital admission was required in 13 patients, 4 of which were admitted to an intensive care setting. Nine patients required operative intervention. Mean length of hospital stay was 2.4 days. No patients were expired.
Conclusions Sports-related facial fractures are potentially debilitating injuries in the pediatric population. Analysis of fracture pattern and concomitant injuries is imperative to develop effective management strategies and prevention techniques.
A 13-Year-Old Boy Who Has Kawasaki Disease Shock Syndrome Presents with Parotitis
Authors: Yozgat Yilmaz , Uzuner Selcuk , Demir Aysegul Dogan , Ogur Mustafa , Yozgat Can Yilmaz , Turel Ozden 
Published: October 2019

AbstractWe report a 13-year-old boy who (initially) had symptoms of toxic shock-like syndrome and mumps. Then, the patient was hospitalized in the pediatric intensive care unit (PICU) because of his ongoing hemodynamic instability (low blood pressure of 70/30 mm Hg and capillary refill time of > 4 seconds). During his stay in the PICU, the patient was treated with fluid resuscitation and vasoactive infusion and at the same time was diagnosed with Kawasaki disease shock syndrome (KDSS), when giant right coronary artery aneurysms were detected on echocardiographic examination. This case illustrates the risk of KDSS in patient who carries both parotitis and toxic shock-like syndrome. The clinicians should be cautious about detecting any types of coronary artery aneurysms in such patients. This is the first case of KDSS associated with parotitis reported in the literature.
Venous Thrombosis in Acquired Hemophilia: The Complex Management of Competing Pathologies
Authors: Chhabra Manu , Hii Zhen Wan Stephanie , Rajendran Joseph , Ponnudurai Kuperan , Fan Bingwen Eugene 
Published: October 2019

Abstract
Introduction Venous thrombosis is rare in the setting of factor VIII (FVIII) deficiency. Cases of deep vein thrombosis (DVT) have been described in hemophiliacs after recent major surgery, or in association with the administration of FVIII concentrate and activated prothrombin complex concentrates, but occurrence of spontaneous DVT is even more uncommon.
Aim We describe the challenging management of extensive DVT in a patient with acquired hemophilia A with concurrent hemorrhagic manifestations and review similar published cases.
Methods We summarize a series of 10 cases with the following demographics: 6 males and 4 females; median age at presentation of 65 (21–80); mean inhibitor titer of 68.5 Bethesda Units (BU 1.9 to BU 350).
Results Four cases were idiopathic and six had associated conditions (cancer [two cases], recent pregnancy [two cases], and recent surgery [two cases]). Three cases had an inferior vena cava filter inserted for acute lower limb DVT/pulmonary embolism. Inhibitor eradication was achieved with high-dose steroids with or without cyclophosphamide, and adjunct Rituximab administration was used in three cases. One patient received concurrent therapeutic plasma exchange (TPE). Inhibitor eradication was fastest with concurrent TPE at 6 days (range: 6–733 days). The 30-day survival was 90%.
Conclusions There was adequate response of inhibitors to immunosuppression with steroids and cyclophosphamide therapy. For more refractory disease, Rituximab is emerging as a beneficial and cost-effective adjunct with better rates of complete remission, and the threshold for its use may be lowered in this complex cohort with dual competing pathologies.
An artificial neural network approach in predicting career strand of incoming senior high school students
Authors: Nazareno A L , Lopez M J F , Gestiada G A , Martinez M P , Roxas-Villanueva R M 
Published: October 2019

Abstract
The K to 12 program has been implemented in the Philippines by the Department of Education which implicated an additional two years in the students’ basic education. These ancillary years allow senior high school students to take courses under the core curriculum and the track of choice. Each student must select one track to pursue that can equip him/her with skills to prepare for the future. Prediction of choice of career track in senior high school is advantageous for educational institutions since it gives insights that can help them develop vital programs beneficial for students’ learning in school. In this study, we applied artificial neural network (ANN) to predict the career strand based on the students’ grades in five major subjects. Different ANN models have been considered and compared. In training and testing the models, a sample of 293 student data information was used. The highest accuracy recorded among all the models was 74.1 %.
Stochastic Simulation of Yeast Cells and Its Colony Growth by Using Circular Granular Model for Cases of Growth and Birth Probabilities Depends on Position
Authors: Purwa Aji Dimas Praja , Aprianti Devi , Viridi Sparisoma 
Published: October 2019

Abstract
Until now, many studies were conducted on microorganisms in order to make the best use of them and prevent the loss. As a type of microorganism that is widely utilized by humans, the yeast has a simple single cell structure that can represent many other complex cell processes and generally has almost elliptical shapes making it easier to model for further investigation. In this study, we model yeast cells with two dimensional circular granular particles and the interaction between them are modeled by the force of gravity, normal force, and Stokes force. The growth and birth factor of yeast cells are modeled stochastic with the simulation is done by using javascript programming language. From the simulation results obtained, showing the growth of yeast cells in the colony has a behavior that is in accordance with the theory, which grows exponentially, as well as the growth of the size of the colony radius whose growth rate is half to the rate of growth of its number of cells.
Traffic flow simulation using agent-based model: A case of single lane with multiple traffic lights and input-output node
Authors: Viridi S , Dwitasari M , Takaendengan M , Sari KN , Pasaribu US 
Published: October 2019

Abstract
Vehicle is modeled as a point, which is moving along a closed trajectory. A small amount of time is defined as the time step, the smallest time difference, so that any time measurement is simply multiple of this value. Lowest positive velocity (but greater than zero) is where in the time step a vehicle advances its position for only a spatial step. Higher velocities and also the negative ones can be constructed from this value. Only a single lane is investigated in this work, where a vehicle must wait until there is an empy space in front of it before it can move forward. As pertubation several traffice lights are also installed in the trajectory. Number of vehicles stop at a stoplight or N
stop is observed.
Tortuosity and Percolation Probability on 3 Dimensional Rock Models with Different Model Sizes
Authors: Ramadhan FW , Fauzi U 
Published: October 2019

Abstract
Tortuosity, percolation probability and porosity are important rock parameters because all those things affect the fluid flow in rocks. In this study, 3-dimensional cube-shaped rock models were randomly generated with N × N × N size containing matrices and pores. Rock models were made with porosities ranging from 0.1 to 1 with increasing of value 0.1. The selected N is N = 5, 6, 7, 8, 9, 10, 25, 125 and for every N there are 10,000 random configurations. Then, tortuosity was calculated using a nearest-neighbor sites method with 6 neighboring sides. In addition, with the site percolation model, percolation probability was calculated by determining the comparison between the number of percolate configurations and the total number of configurations created. The results show that in large-size rock models, the average tortuosity will increase. Further, the percolation probability is zero at a small porosity and rises to 1 as the porosity increases. Moreover, the slope of the percolation probability curve will increase for the larger model. In other words, the larger the size of the model, the percolation threshold will become larger or more difficult to percolate for small porosity.
Report on Sky Brightness, Seeing, and Weather Measurements at Timau Observatory, East Nusa Tenggara
Authors: Akbar E I , Jatmiko A T P , Putra M , Nurzaman M Z , Mumpuni E S , Mandey D , Raharto M 
Published: October 2019

Abstract
In 2015, a joint collaboration project to build a new observatory in Mount Timau, East Nusa Tenggara was initiated between LAPAN, ITB, UNDANA, Kupang Regency and East Nusa Tenggara governments. The site selection is based on preliminary studies conducted on nearby location. This paper presents in situ measurements report on seeing, weather and sky brightness obtained on July 2018 using Differential Image Motion Monitor (DIMM) with 20 cm-telescope, Davis Vantage Vue automatic weather station, and Sky Quality Meter, respectively. Despite the high humidity and foggy condition on the afternoon, the site has good seeing condition with median of 0.93 arcsecond and sky brightness around 22.18 magnitude per arcsecond square after midnight.
In-Vitro Study of DNA Adduct 8-Hydroxy-2’-Deoxyguanosine Formation from 2’-Dexoyguanosine Exposure Against Benzo[a]pyrene and Ni(II) Compounds Through Fenton-Like Reactions
Authors: Farozy Ikko Haidar , Handayani Sri , Budiawan  , Dani Intan Cahaya 
Published: October 2019

Abstract
This research was performed to study the process of 8-hydroxy-2’-deoxyguanosine (8-OHdG) adduct formation as biomarker that used for early cancer detection in humans. This in-vitro study was conducted by reacting 2’-deoxyguanosine as one of the bases of DNA against benzo[a]pyrene (B[a]P) as xenobiotic, Ni(II), and H2O2, to study the effects of 2’- deoxyguanosine (2’-dG) exposure against xenobiotic through Fenton-like reaction. The reaction was incubated at 37°C for 18 hours in a shaker incubator. The reactions were varied at pH 7.4 and 8.4. The reaction products were then analyzed by using reverse phase HPLC with UV-Vis detector. The mobile phase used was a mixture of phosphate buffer and methanol with composition of 90:10. It was observed that exposure of 2’-dG against B[a]P and H2O2 and also B[a]P, Ni(II), and H2O2 both produced 8-OHdG. The higher 8-OHdG yield was obtained from the exposure of 2’-dG against B[a]P, Ni(II), and H2O2 compared to exposure against B[a]P and H2O2, which can be attributed to stronger effects from Fenton-like reaction. It was also observed that at similar exposure conditions, the 8-OHdG formation was higher at pH 7.4 compared to pH 8.4.
Synthesis of Fe3O4 nanoparticles for colour removal of printing ink solution
Authors: Jannah N R , Onggo D 
Published: October 2019

Abstract
Fe3O4 nanoparticles can be used as an adsorbent for colour removal of printing ink which contribute as a pollutant in wastewater. Fe3O4 was synthesized by coprecipitation method using FeCl3.6H2O and (NH4)2Fe(SO4)2.6H2O precursors dissolved in distilled water in mol ratio of Fe3+: Fe2+ = 2:1. NaOH solution was added slowly into the iron solution with continuous stirring for 60 minutes in Argon gas atmosphere. After drying, Fe3O4 nanoparticle product is obtained as black crystalline powder with an average particle size about 34 nm. The Fe3O4 nanoparticles (0.1 g) were able to remove blue, red, and yellow colour with percentage of adsorption about 97%, 94%, and 62% for 40 minutes contact time and 100 rpm of stirring speed, respectively. Fe3O4 nanoparticle can be separated from the printing ink solution by an external magnetic field.
Bayesian Quantile Regression Method to Construct the Low Birth Weight Model
Authors: Yanuar Ferra , Zetra Aidinil , Muharisa Catrin , Devianto Dodi , Putri Arrival Rince , Asdi Yudiantri 
Published: October 2019

Abstract
This study aims to implement Bayesian quantile regression method in constructing the model of Low Birth Weight. The data of Low Birth Weight is violated of nonnormal assumption for error terms. This study considers quantile regression approach and use Gibbs sampling algorithm from Bayesian method for fitting the quantile regression model. This study explores the performance of the asymmetric Laplace distribution for working likelihood in posterior estimation process. This study also compare the result of variable selection in quantile regression and Bayesian quantile regression for Low Birth Weight model. This study. proved that Bayesan quantile method produced better model than just quantile approach. Bayesian quantile method proved that it can handle the nonnormal problem although using moderate size of data.