bluuebunny/crossref_metadata_2025_split huggingface dataset:
A TPMS-based method for modeling porous scaffolds for bionic bone tissue engineering
Authors: Shi Jianping , Zhu Liya , Li Lan , Li Zongan , Yang Jiquan , Wang Xingsong 
Published: May 2018

AbstractIn the field of bone defect repair, gradient porous scaffolds have received increased attention because they provide a better environment for promoting tissue regeneration. In this study, we propose an effective method to generate bionic porous scaffolds based on the TPMS (triply periodic minimal surface) and SF (sigmoid function) methods. First, cortical bone morphological features (e.g., pore size and distribution) were determined for several regions of a rabbit femoral bone by analyzing CT-scans. A finite element method was used to evaluate the mechanical properties of the bone at these respective areas. These results were used to place different TPMS substructures into one scaffold domain with smooth transitions. The geometrical parameters of the scaffolds were optimized to match the elastic properties of a human bone. With this proposed method, a functional gradient porous scaffold could be designed and produced by an additive manufacturing method.
Synergistic effect of renalase and chronic kidney disease on endothelin-1 in patients with coronary artery disease ‒ a cross-sectional study
Authors: Li Yu-Hsuan , Sheu Wayne Huey-Herng , Lee Wen-Jane , Wang Jun -Sing , Fu Chia-Po , Liang Kae-Woei , Lee I-Te 
Published: May 2018

AbstractEndothelin-1 (ET-1) is associated with endothelial dysfunction and vasoconstriction. Increased circulating ET-1 levels are associated with long-term cardiovascular mortality. Renalase, released from kidney, metabolizes catecholamines and regulates blood pressure. An increase in circulating renalase levels has been reported in patients with chronic kidney disease (CKD) and is associated with coronary artery disease (CAD). We hypothesized the existence of a synergistic effect of serum renalase levels and CKD on ET-1 levels in patients with CAD. We evaluated 342 non-diabetic patients with established CAD. ET-1 and renalase levels were measured in all patients after an overnight fast. Patients with CKD had higher ET-1 (1.95 ± 0.77 vs. 1.62 ± 0.76 pg/ml, P < 0.001) and renalase levels (46.8 ± 17.1 vs. 33.9 ± 9.9 ng/ml, P < 0.001) than patients without CKD. Patients with both CKD and high renalase levels (>the median of 36.2 ng/ml) exhibited the highest serum ET-1 (P value for the trend <0.001). According to multivariate linear regression analysis, the combination of high serum renalase levels with CKD was a significant risk factor for increased serum ET-1 levels (regression coefficient = 0.297, 95% confidence interval = 0.063‒0.531, P = 0.013). In conclusion, our data suggest a synergistic effect of high serum renalase levels and CKD on increases in ET-1 levels in patients with established CAD.
Identifying Suicide Ideation and Suicidal Attempts in a Psychiatric Clinical Research Database using Natural Language Processing
Authors: Fernandes Andrea C. , Dutta Rina , Velupillai Sumithra , Sanyal Jyoti , Stewart Robert , Chandran David 
Published: May 2018

AbstractResearch into suicide prevention has been hampered by methodological limitations such as low sample size and recall bias. Recently, Natural Language Processing (NLP) strategies have been used with Electronic Health Records to increase information extraction from free text notes as well as structured fields concerning suicidality and this allows access to much larger cohorts than previously possible. This paper presents two novel NLP approaches – a rule-based approach to classify the presence of suicide ideation and a hybrid machine learning and rule-based approach to identify suicide attempts in a psychiatric clinical database. Good performance of the two classifiers in the evaluation study suggest they can be used to accurately detect mentions of suicide ideation and attempt within free-text documents in this psychiatric database. The novelty of the two approaches lies in the malleability of each classifier if a need to refine performance, or meet alternate classification requirements arises. The algorithms can also be adapted to fit infrastructures of other clinical datasets given sufficient clinical recording practice knowledge, without dependency on medical codes or additional data extraction of known risk factors to predict suicidal behaviour.
Growth of ‘W’ doped molybdenum disulfide on graphene transferred molybdenum substrate
Authors: Asokan Vijayshankar , Zhu Dancheng , Huang Wei , Wang Hulian , Gao Wandong , Zhang Ze , Jin Chuanhong 
Published: May 2018

AbstractIn the present study, a novel method has been carried out to grow tungsten (W) doped molybdenum disulfide (MoS2) on the graphene transferred TEM grid in a chemical vapor deposition (CVD) setup. Tungsten trioxide (WO3) has been used as a source for ‘W’ while ‘Mo’ has been derived from Mo based substrate. Different experimental parameters were used in this experiment. Higher gas flow rate decreases the size of the sample flake and on other side increases the dopant concentrations. The interaction mechanism between Mo, S, W and oxygen (O) have been explored. The influence of oxygen seems to be not avoidable completely which also imposes effective growth condition for the reaction of Mo with incoming sulfur atoms. The difference in the migration energies of Mo, WO3, S clusters on the graphene and the higher reactivity of Mo clusters over other possibly formed atomic clusters on the graphene leads to the growth of W doped MoS2 monolayers. Formation of MoS2 monolayer and the nature of edge doping of ‘W’ is explained well with the crystal model using underlying nucleation principles. We believe our result provide a special route to prepare W doped MoS2 on graphene substrate in the future.
Impact of UGT1A1 polymorphisms on Raltegravir and its glucuronide plasma concentrations in a cohort of HIV-1 infected patients
Authors: Belkhir Leïla , Seguin-Devaux Carole , Elens Laure , Pauly Caroline , Gengler Nicolas , Schneider Serge , Ruelle Jean , Haufroid Vincent , Vandercam Bernard 
Published: May 2018

AbstractThe aim of this study was to evaluate the effect of UGT1A1 polymorphisms on Raltegravir (RAL) and its metabolite RAL-glucuronide trough plasma concentrations ([RAL]plasma and [RAL-glu]plasma) and on the metabolic ratio (MR): [RAL-glu]plasma/[RAL]plasma. UGT1A1 genotyping was performed on 96 patients. 44% (n = 42) were homozygous UGT1A1*1/*1 while 50% (n = 48) and 6% (n = 6) were UGT1A1*28 and UGT1A1*36 carriers, respectively. The median concentration and interquartile range (IQR) of [RAL]plasma were 88.5 ng/ml (41.0–236), 168 ng/ml (85.8–318) and 92.5 ng/ml (36.4–316) for UGT1A1*1/*1, UGT1A1*28 and UGT1A1*36 carriers, respectively. Only the difference between UGT1A1*1/*1 and *28 carriers was statistically significant (p = 0.022). The median MR (IQR) were 5.8 (3–10), 2.9 (1.6–5.3) and 3.2 (1.7–5.9) for UGT1A1*1/*1, UGT1A1*28 and UGT1A1*36 carriers, respectively. Only the difference between UGT1A1*1/*1 and *28 carriers was statistically significant (p = 0.004) with an allele-dependent effect: UGT1A1*28 homozygous having lower MR than heterozygous carriers who show lower MR compared to *1/*1. Except for the sensation of fatigue, this PK effect did not correlate with clinical adverse events or biological abnormalities. In Conclusion, we demonstrate that UGT1A1*28 polymorphism has a significant impact on RAL metabolism: UGT1A1*28 carriers being characterized by higher [RAL]plasma and lower MR.
Co-regulation of photosynthetic capacity by nitrogen, phosphorus and magnesium in a subtropical Karst forest in China
Authors: Wang Jing , Wen Xuefa , Zhang Xinyu , Li Shenggong , Zhang Da-Yong 
Published: May 2018

AbstractLeaf photosynthetic capacity is mainly constrained by nitrogen (N) and phosphorus (P). Little attention has been given to the photosynthetic capacity of mature forests with high calcium (Ca) and magnesium (Mg) in the Karst critical zone. We measured light-saturated net photosynthesis (Asat), photosynthetic capacity (maximum carboxylation rate [Vcmax], and maximum electron transport rate [Jmax]) as well as leaf nutrient contents (N, P, Ca, Mg, potassium [K], and sodium [Na]), leaf mass per area (LMA), and leaf thickness (LT) in 63 dominant plants in a mature subtropical forest in the Karst critical zone in southwestern China. Compared with global data, plants showed higher Asat for a given level of P. Vcmax and Jmax were mainly co-regulated by N, P, Mg, and LT. The ratios of Vcmax to N or P, and Jmax to N or P were significantly positively related to Mg. We speculate that the photosynthetic capacity of Karst plants can be modified by Mg because Mg can enhance photosynthetic N and P use efficiency.
Three-Dimensional Printed Electrode and Its Novel Applications in Electronic Devices
Authors: Foo Chuan Yi , Lim Hong Ngee , Mahdi Mohd Adzir , Wahid Mohd Haniff , Huang Nay Ming 
Published: May 2018

AbstractThree-dimensional (3D) printing technology provides a novel approach to material fabrication for various applications because of its ability to create low-cost 3D printed platforms. In this study, a printable graphene-based conductive filament was employed to create a range of 3D printed electrodes (3DEs) using a commercial 3D printer. This printing technology provides a simplistic and low-cost approach, which eliminates the need for the ex-situ modification and post-treatment of the product. The conductive nature of the 3DEs provides numerous deposition platforms for electrochemical active nanomaterials such as graphene, polypyrrole, and cadmium sulfide, either through electrochemical or physical approaches. To provide proof-of-concept, these 3DEs were physiochemically and electrochemically evaluated and proficiently fabricated into a supercapacitor and photoelectrochemical sensor. The as-fabricated supercapacitor provided a good capacitance performance, with a specific capacitance of 98.37 Fg−1. In addition, these 3DEs were fabricated into a photoelectrochemical sensing platform. They had a photocurrent response that exceeded expectations (~724.1 μA) and a lower detection limit (0.05 μM) than an ITO/FTO glass electrode. By subsequently modifying the printing material and electrode architecture, this 3D printing approach could provide a facile and rapid manufacturing process for energy devices based on the conceptual design.
Long-term Outcome of Recoverable stents for Budd-Chiari syndrome Complicated with Inferior Vena Cava Thrombosis
Authors: Bi Yonghua , Chen Hongmei , Ding Penxu , Ren Jianzhuang , Han Xinwei 
Published: May 2018

AbstractThis study aimed to present long-term results of a 12-year patient follow-up of recoverable stents for BCS complicated by inferior vena cava (IVC) thrombosis. Forty consecutive patients with BCS complicated by IVC thrombosis were treated with recoverable stents. The median duration of symptoms was 24 months. Recoverable stents was placed after predilation of the obstructed IVC, and then agitation thrombolysis or catheter-directed thrombolysis of IVC was performed. The recoverable stents was removed eventually after thrombus disappeared. Clinical patency was defined as absence or improvement of symptoms. Patients were subsequently followed-up by color Doppler ultrasound. Recoverable stents placement, balloon angioplasty and thrombolysis were technically successful in all patients. Stents were successfully removed in 92.1% of patients. A few serious related complications including one acute pulmonary thromboembolism, one stent migration, and one failure retrieval stents occurred. The median follow-up was 43.7 months. The long-term results were satisfactory except 2 patients who presented with a restenosis or re-obstruction and underwent additional therapy. There were 5 deaths owing to pulmonary embolism or underlying malignant disease 0.4–101.8 months after the procedures, including one procedure-related death. In conclusion, Recoverable stents treatment is safe and effective for BCS complicated by IVC thrombosis, with a good long-term outcome.
PCSK9 inhibition with alirocumab reduces lipoprotein(a) levels in nonhuman primates by lowering apolipoprotein(a) production rate
Authors: Croyal Mikaël , Tran Thi-Thu-Trang , Blanchard Rose Hélène , Le Bail Jean-Christophe , Villard Elise F. , Poirier Bruno , Aguesse Audrey , Billon-Crossouard Stéphanie , Ramin-Mangata Stéphane , Blanchard Valentin , Nativel Brice , Chemello Kévin , Khantalin Ilya , Thedrez Aurélie , Janiak Philip , Krempf Michel , Boixel Christophe , Lambert Gilles , Guillot Etienne 
Published: May 2018

Therapeutic antibodies targeting proprotein convertase subtilisin kexin type 9 (PCSK9) (e.g. alirocumab) lower low-density lipoprotein cholesterol (LDL-C) and lipoprotein (a) [Lp(a)] levels in clinical trials. We recently showed that PCSK9 enhances apolipoprotein(a) [apo(a)] secretion from primary human hepatocytes but does not affect Lp(a) cellular uptake. Here, we aimed to determine how PCSK9 neutralization modulates Lp(a) levels in vivo.
Six nonhuman primates (NHP) were treated with alirocumab or a control antibody (IgG1) in a crossover protocol. After the lowering of lipids reached steady state, NHP received an intravenous injection of [2H3]-leucine, and blood samples were collected sequentially over 48 h. Enrichment of apolipoproteins in [2H3]-leucine was assessed by liquid chromatography–tandem mass spectrometry (LC–MS/MS). Kinetic parameters were calculated using numerical models with the SAAMII software. Compared with IgG1, alirocumab significantly reduced total cholesterol (TC) (−28%), LDL-C (−67%), Lp(a) (−56%), apolipoprotein B100 (apoB100) (−53%), and apo(a) (−53%). Alirocumab significantly increased the fractional catabolic rate of apoB100 (+29%) but not that of apo(a). Conversely, alirocumab sharply and significantly reduced the production rate (PR) of apo(a) (−42%), but not significantly that of apoB100, compared with IgG1, respectively.
In line with the observations made in human hepatocytes, the present kinetic study establishes that PCSK9 neutralization with alirocumab efficiently reduces circulating apoB100 and apo(a) levels by distinct mechanisms: apoB primarily by enhancing its catabolism and apo(a) primarily by lowering its production.
10 A/567 V normally off p‐GaN gate HEMT with high‐threshold voltage and low‐gate leakage current
Authors: Hao Ronghui , Wu Dongdong , Fu Kai , Song Liang , Chen Fu , Zhao Jie , Du Zhongkai , Zhang Bingliang , Wang Qilong , Yu Guohao , Cheng Kai , Cai Yong , Zhang Xinping , Zhang Baoshun 
Published: May 2018

Normally off p‐gallium nitride (GaN) gate high‐electron‐mobility transistors (HEMTs) on silicon substrate were fabricated with hydrogen plasma treatment technology, which features a high‐resistivity cap layer (HRCL) at the access region. With hydrogen plasma treatment at the access region, the normally off operation was obtained with a threshold voltage of +2.5 V based on the linear extrapolation of the transfer curve. The fabricated HRCL‐HEMT with a gate width of 49.7 mm exhibits a maximum drain current of 10 A at VGS = 8 V and a high off‐state breakdown voltage of 567 V at VGS = 0 V with substrate grounded. Meanwhile, the HRCL‐HEMT also shows low‐gate leakage current of 1.3 × 10−7 and 3.3 × 10−10 A/mm at VGS = 8 V and = −30 V, respectively. The positive threshold voltage, high drain current, high‐breakdown voltage and low‐gate leakage show the potential of HRCL‐HEMT for power switching applications.
Voltage slope‐based zero voltage switching detection method for wireless power transfer systems
Authors: Li Siqi , Shu Wenbin , Lu Sizhao 
Published: May 2018

A zero voltage switching (ZVS) detection method, which relies on the half‐bridge output voltage slopes during the MOSFET turn‐on and turn‐off transient processes, is proposed for the wireless power transfer (WPT) systems in this Letter. A voltage slope detection circuit and its active control method are also proposed to convert the nanosecond transient signal to a steady voltage level, which can be handled by the microcontroller easily. By having the information of the turn‐on and turn‐off voltage slopes, the state of ZVS can be evaluated to optimise the switching losses. A 500 kHz, three‐coil resonant WPT system is built in order to evaluate the performance of the proposed detection method. Experimental results show that the ZVS state can be detected effectively. Also, the turn‐off current can be controlled to a constant value to optimise the switching losses under the load and parameter variations.
Impedance matching theory to design an all‐optical AND gate
Authors: Mondal Haraprasad , Sen Mrinal , Prakash Chandra , Goswami Kamanashis , Sarma Champak Kumar 
Published: May 2018

An impedance matching theory‐based methodology is presented in this study for designing/optimising photonic crystal‐based all‐optical AND gate. A basic architecture for the AND gate is projected first, and thereafter the same is optimised utilising the proposed methodology. Performance of the AND gate is evaluated based on several metrics that are calculated using a finite‐difference‐time‐domain simulation. The optimised AND gate has exhibited a high extinction ratio in the order of 6.9 dB, within a very small footprint of . It also supports propagation of a high bit rate (≈1 Tb/S) and has a wide operational bandwidth (≈4 THz), which make the device suitable for different photonic integrated circuit applications.
A new approach to distant solar system object detection in large survey data sets
Authors: Perdelwitz V. , Völschow M. , Müller H. M. 
Published: May 2018

Context. The recently postulated existence of a giant ninth planet in our solar system has sparked search efforts for distant solar system objects (SSOs) both via new observations and archival data analysis. Due to the likely faintness of the object in the optical and infrared regime, it has so far eluded detection.
Aims. We set out to re-analyze data acquired by the Wide-Field Infrared Survey Explorer (WISE), an all-sky survey well suited for the detection of SSOs.
Methods. We present a new approach to SSO detection via parallactic fitting. Using the heliocentric distance as a fit parameter, our code transforms groups of three or more single-observation point sources to heliocentric coordinates under the assumption that all data stem from an object. The fact that the orbit of a distant SSO is approximately linear in heliocentric coordinates over long time-scales can be utilized to produce candidates, which can then be confirmed with follow-up observations.
Results. We demonstrate the feasibility of the approach by a posteriori detecting the outer SSO Makemake within WISE data. An all-sky search for Planet Nine yielded no detection.
Conclusions. While the postulated Planet Nine eluded detection by our algorithm, we tentatively predict that this new approach to moving-object analysis will enable the discovery of new distant SSOs that cannot be discovered by other algorithms. Especially in cases of sparse data observed over long time spans, our approach is unique and robust due to the use of only one fit parameter.
Solar barycentric dynamics from a new solar-planetary ephemeris
Authors: Cionco Rodolfo G. , Pavlov Dmitry A. 
Published: May 2018

Aims. The barycentric dynamics of the Sun has increasingly been attracting the attention of researchers from several fields, due to the idea that interactions between the Sun’s orbital motion and solar internal functioning could be possible. Existing high-precision ephemerides that have been used for that purpose do not include the effects of trans-Neptunian bodies, which cause a significant offset in the definition of the solar system’s barycentre. In addition, the majority of the dynamical parameters of the solar barycentric orbit are not routinely calculated according to these ephemerides or are not publicly available.
Methods. We developed a special version of the IAA RAS lunar–solar–planetary ephemerides, EPM2017H, to cover the whole Holocene and 1 kyr into the future. We studied the basic and derived (e.g., orbital torque) barycentric dynamical quantities of the Sun for that time span. A harmonic analysis (which involves an application of VSOP2013 and TOP2013 planetary theories) was performed on these parameters to obtain a physics-based interpretation of the main periodicities present in the solar barycentric movement.
Results. We present a high-precision solar barycentric orbit and derived dynamical parameters (using the solar system’s invariable plane as the reference plane), widely accessible for the whole Holocene and 1 kyr in the future. Several particularities and barycentric phenomena are presented and explained on dynamical bases. A comparison with the Jet Propulsion Laboratory DE431 ephemeris, whose main differences arise from the modelling of trans-Neptunian bodies, shows significant discrepancies in several parameters (i.e., not only limited to angular elements) related to the solar barycentric dynamics. In addition, we identify the main periodicities of the Sun’s barycentric movement and the main giant planets perturbations related to them.
Type Ia supernova Hubble diagram with near-infrared and optical observations
Authors: Stanishev V. , Goobar A. , Amanullah R. , Bassett B. , Fantaye Y. T. , Garnavich P. , Hlozek R. , Nordin J. , Okouma P. M. , Östman L. , Sako M. , Scalzo R. , Smith M. 
Published: May 2018

Context.Type Ia Supernovae (SNe Ia) have been used as standardizable candles in the optical wavelengths to measure distances with an accuracy of ~7% out to redshiftz~ 1.5. There is evidence that in the near-infrared (NIR) wavelengths SNe Ia are even better standard candles, however, NIR observations are much more time-consuming.Aims.We aim to test whether the NIR peak magnitudes could be accurately estimated with only a single observation obtained close to maximum light, provided that the time ofBband maximum, theB−Vcolor at maximum and the optical stretch parameter are known.Methods.We present multi-epochUBV RIand single-epochJandHphotometric observations of 16 SNe Ia in the redshift rangez= 0.037 − 0.183, doubling the leverage of the current SN Ia NIR Hubble diagram and the number of SNe beyond redshift 0.04. This sample was analyzed together with 102 NIR and 458 optical light curves (LCs) of normal SNe Ia from the literature.Results.The analysis of 45 NIR LCs with well-sampled first maximum shows that a single template accurately describes the LCs if its time axis is stretched with the optical stretch parameter. This allows us to estimate the peak NIR magnitudes of SNe with only few observations obtained within ten days fromB-band maximum. The NIR Hubble residuals show weak correlation with ΔM15and the color excessE(B−V), and for the first time we report a potential dependence on theJmax−Hmaxcolor. With these corrections, the intrinsic NIR luminosity scatter of SNe Ia is estimated to be ~0.10 mag, which is smaller than what can be derived for a similarly heterogeneous sample at optical wavelengths. Analysis of both NIR and optical data shows that the dust extinction in the host galaxies corresponds to a lowRV≃ 1.8–1.9.Conclusions.We conclude that SNe Ia are at least as good standard candles in the NIR as in the optical and are potentially less affected by systematic uncertainties. We extended the NIR SN Ia Hubble diagram to its nonlinear part atz~ 0.2 and confirmed that it is feasible to accomplish this result with very modest sampling of the NIR LCs, if complemented by well-sampled optical LCs. With future facilities it will be possible to extend the NIR Hubble diagram beyond redshiftz≃ 1, and our results suggest that the most efficient way to achieve this would be to obtain a single observation close to the NIR maximum.