bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pediatric ovarian angiosarcoma treated with systemic chemotherapy and cytoreductive surgery with heated intraperitoneal chemotherapy: Case report and review of therapy
Authors: Pariury Holly , Golden Carla , Huh Winston W. , Cham Elaine , Chung Taylor , Hayes‐Jordan Andrea 
Published: April 2019

AbstractOvarian angiosarcoma is a rare and aggressive vascular tumor, which has a 5‐year overall survival of less than 30% for patients with nonmetastatic disease and almost certain death within 1 year for those with metastasis. Here, we briefly review historical approaches to therapy and present a long‐term survivor in the case of an 11‐year‐old female with metastatic ovarian angiosarcoma. This is the second reported case to utilize heated intraperitoneal chemotherapy in the treatment of this disease. Our patient is currently alive and well 3 years after initial diagnosis, significantly longer than any reported case of advanced‐stage ovarian angiosarcoma.
One‐step deposition of nano‐Ag‐TiO2 coatings by atmospheric pressure plasma jet for water treatment: Application to trace pharmaceutical removal using solar photocatalysis
Authors: Peng Tao , Pulpytel Jerome , Horovitz Inna , Jaiswal Abhay Kumar , Avisar Dror , Mamane Hadas , Lalman Jerald Anthony , Arefi‐Khonsari Farzaneh 
Published: April 2019

AbstractIn this study, micrometer thick Ag‐TiO2 coatings were deposited in a single and facile step by spraying the precursor in an atmospheric pressure plasma jet with different concentrations of Ag nanoparticles. The homogenous distribution of Ag decreased the TiO
2 crystal size and increased the surface area. The coatings were characterized to be porous with an anatase phase with improved charge separation and visible light absorption. The photocatalytic activity of the materials was investigated for degrading rhodamine B using a white lamp as a screening method to optimize Ag‐TiO
2 coatings. Then the photodegradation of trace pharmaceutical compounds (TrPCs) was investigated by using a solar light simulator at the optimal condition of a TiO
2 coating with 0.4wt% Ag.
The structure of Trametes versicolor glutathione transferase Omega 3S bound to its conjugation product glutathionyl‐phenethylthiocarbamate reveals plasticity of its active site
Authors: Schwartz Mathieu , Perrot Thomas , Morel‐Rouhier Mélanie , Mulliert Guillermo , Gelhaye Eric , Didierjean Claude , Favier Frédérique 
Published: April 2019

Abstract
Trametes versicolor glutathione transferase Omega 3S (TvGSTO3S) catalyzes the conjugation of isothiocyanates (ITC) with glutathione (GSH). Previously, this isoform was investigated in depth both biochemically and structurally. Structural analysis of complexes revealed the presence of a GSH binding site (G site) and a deep hydrophobic binding site (H site) able to bind plant polyphenols. In the present study, crystals of apo TvGSTO3S were soaked with glutathionyl‐phenethylthiocarbamate, the product of the reaction between GSH and phenethyl isothiocyanate (PEITC). On the basis of this crystal structure, we show that the phenethyl moiety binds in a new site at loop β2‐α2 while the glutathionyl part exhibits a particular conformation that occupies both the G site and the entrance to the H site. This binding mode is allowed by a conformational change of the loop β2‐α2 at the enzyme active site. It forms a hydrophobic slit that stabilizes the phenethyl group at a distinct site from the previously described H site. Structural comparison of TvGSTO3S with drosophila DmGSTD2 suggests that this flexible loop could be the region that binds PEITC for both isoforms. These structural features are discussed in a catalytic context.
Electron‐deficient p‐benzoyl‐l‐phenylalanine derivatives increase covalent chemical capture yields for protein–protein interactions
Authors: Joiner Cassandra M. , Breen Meghan E. , Mapp Anna K. 
Published: April 2019

AbstractThe photoactivatable amino acid p‐benzoyl‐l‐phenylalanine (pBpa) has been used for the covalent capture of protein–protein interactions (PPIs) in vitro and in living cells. However, this technique often suffers from poor photocrosslinking yields due to the low reactivity of the active species. Here we demonstrate that the incorporation of halogenated pBpa analogs into proteins leads to increased crosslinking yields for protein–protein interactions. The analogs can be incorporated into live yeast and upon irradiation capture endogenous PPIs. Halogenated pBpas will extend the scope of PPIs that can be captured and expand the toolbox for mapping PPIs in their native environment.
Assessing noninferiority: Evaluating efficacy of a new treatment without complete data
Authors: Gao Ping , Odem‐Davis Katherine 
Published: April 2019

SummaryThe FDA released the final guidance on noninferiority trials in November 2016. In noninferiority trials, validity of the assessment of the efficacy of the test treatment depends on the control treatment's efficacy. Therefore, it is critically important that there be a reliable estimate of the control treatment effect—which is generally obtained from historical trials, and often assumed to hold in the current setting (the assay constancy assumption). Validating the constancy assumption requires clinical data, which are typically lacking. The guidance acknowledges that “lack of constancy can occur for many reasons.” We clarify the objectives of noninferiority trials. We conclude that correction for bias, rather than assay constancy, is critical to conducting valid noninferiority trials. We propose that assay constancy not be assumed and discounting or thresholds be used to address concern about loss of historical efficacy. Examples are provided for illustration.
A resilient consensus strategy of near‐optimal control for state‐saturated multiagent systems with round‐robin protocol
Authors: Yuan Yuan , Shi Min , Guo Lei , Yang Hongjiu 
Published: April 2019

SummaryIn this paper, the resilient consensus strategy design problem is investigated for the time‐varying state‐saturated multiagent systems (MASs). A round‐robin protocol is adopted to schedule the communication network among the MASs for the purpose of preventing the data from collision. In presence of the state‐saturation and gain perturbation phenomena, it is literally impossible to obtain the accurate value of the associate cost function, which describes the consensus performance. As an alternative, an upper bound is derived for the cost function to quantify the consensus performance. Then, the resilient consensus strategy is designed such that this upper bound can be minimized in an iterative manner. The sufficient condition is also provided to guarantee that the upper bound of the cost function exists as time goes to infinity. Finally, a numerical example is provided to illustrate the validity of the proposed methodology.
The association between executive functioning and parental stress and psychological distress is mediated by parental reflective functioning in mothers with substance use disorder
Authors: Håkansson Ulrika , Watten Reidulf G. , Söderström Kerstin , Øie Merete Glenne 
Published: April 2019

AbstractMothers with a substance use disorder (SUD) have been found to exhibit heightened experience of stress and deficits in executive functioning (EF) and in parental reflective functioning (PRF). Although experiences of stress, EF and PRF are important for caregiving capacities; no studies have explored associations between the phenomena in mothers with SUD. This study aimed to examine the association between EF (working memory, inhibition, and cognitive flexibility) and different forms of stress (parental stress, general life stress, and psychological distress) in 43 mothers with SUD with infants. We further aimed to investigate whether PRF had a mediating function between EF and the experience of stress. The mothers completed self‐report questionnaires regarding experiences of different types of stress, and we also used neuropsychological tests to assess EF and a semistructured interview to assess PRF. Results identified problems in EF were associated with higher parental stress and psychological distress but not with general life stress. Cognitive flexibility contributed uniquely to variance in parental stress, whereas working memory was a unique contributor to variance in psychological distress. PRF had a mediating function between EF and parental stress and between EF and psychological distress. Findings highlight the importance of considering individual differences in PRF when targeting EF in interventions trying to reduce the experience of parental stress and psychological distress in mothers with SUD.
The interplay of product and process in skunkworks identity work: An inductive model
Authors: Oliver David , Cole Benjamin M. 
Published: April 2019

Research SummaryThe success of skunkworks often involves nurturing an identity at odds with the parent firm, which may cause de‐identification with the firm and hamper reintegration of team members post‐project. This identity work could lead to market success but organizational failure as skunkworks' members distance themselves from the parent firm tasking the innovation. To explore the when and how of identity work throughout a skunkworks' lifecycle, we studied a skunkworks at an international consumer products company over a 35‐month research window and through post‐hoc interviews some 15 years later. Using a grounded theory approach, we documented the interplay between product (needs) and process (decisions) over the skunkworks' lifecycle, and constructed an inductive model providing important insight to the micro‐foundations of the identity‐based view of competitive advantage.
Managerial SummaryThis study examines how identity work unfolds over time in a skunkworks team created to spur breakthrough innovation. Such teams can develop a strong sense of identity that may in part involve opposition to the parent firm. While this can motivate the team to galvanize around the task at hand, such “othering” may cause de‐identification with the parent and hamper reintegration of team members after the skunkworks is dissolved. Thus, identity work within a skunkworks can lead to both market success and organizational failure. We ground our model in a 35‐month study of an international consumer products company, documenting the interplay between product (needs) and process (decisions) over the skunkworks' lifecycle. We provide prescriptions as to how to mitigate the possibility of these negative outcomes.
Amorphous Mn3O4 Nanocages with High‐Efficiency Charge Transfer for Enhancing Electro‐Optic Properties of Liquid Crystals
Authors: Ma Guanshui , Jia Binbin , Zhao Dongyu , Yang Zhao , Yu Jian , Liu Juzhe , Guo Lin 
Published: April 2019

AbstractImproving electro‐optic properties is essential for fabricating high‐quality liquid crystal displays. Herein, by doping amorphous Mn3O4 octahedral nanocages (a‐Mn3O4 ONCs) into a nematic liquid crystal (NLC) matrix E7, outstanding electro‐optic properties of the blend are successfully obtained. At a doping concentration of 0.03 wt%, the maximum decreases of threshold voltage (Vth) and saturation voltage (Vsat) are 34% and 31%, respectively, and the increase of contrast (Con) is 160%. This remarkable electro‐optic activity can be attributed to high‐efficiency charge transfer within the a‐Mn3O4 ONCs NLC system, caused by metastable electronic states of a‐Mn3O4 ONCs. To the best of our knowledge, such remarkable decreased electro‐optic activity is observed for the first time from doping amorphous semiconductors, which could provide a new pathway to develop excellent energy‐saving amorphous materials and improve their potential applications in electro‐optical devices.
Chemical Properties, Structural Properties, and Energy Storage Applications of Prussian Blue Analogues
Authors: Li Wei‐Jie , Han Chao , Cheng Gang , Chou Shu‐Lei , Liu Hua‐Kun , Dou Shi‐Xue 
Published: April 2019

AbstractPrussian blue analogues (PBAs, A2T[M(CN)6], A = Li, K, Na; T = Fe, Co, Ni, Mn, Cu, etc.; M = Fe, Mn, Co, etc.) are a large family of materials with an open framework structure. In recent years, they have been intensively investigated as active materials in the field of energy conversion and storage, such as for alkaline‐ion batteries (lithium‐ion, LIBs; sodium‐ion, NIB; and potassium‐ion, KIBs), and as electrochemical catalysts. Nevertheless, few review papers have focused on the intrinsic chemical and structural properties of Prussian blue (PB) and its analogues. In this Review, a comprehensive insight into the PBAs in terms of their structural and chemical properties, and the effects of these properties on their materials synthesis and corresponding performance is provided.
Key Aspects of Lithium Metal Anodes for Lithium Metal Batteries
Authors: Ghazi Zahid Ali , Sun Zhenhua , Sun Chengguo , Qi Fulai , An Baigang , Li Feng , Cheng Hui‐Ming 
Published: April 2019

AbstractRechargeable batteries are considered promising replacements for environmentally hazardous fossil fuel‐based energy technologies. High‐energy lithium‐metal batteries have received tremendous attention for use in portable electronic devices and electric vehicles. However, the low Coulombic efficiency, short life cycle, huge volume expansion, uncontrolled dendrite growth, and endless interfacial reactions of the metallic lithium anode are major obstacles in their commercialization. Extensive research efforts have been devoted to address these issues and significant progress has been made by tuning electrolyte chemistry, designing electrode frameworks, discovering nanotechnology‐based solutions, etc. This Review aims to provide a conceptual understanding of the current issues involved in using a lithium metal anode and to unveil its electrochemistry. The most recent advancements in lithium metal battery technology are outlined and suggestions for future research to develop a safe and stable lithium anode are presented.
Low-Dose Pesticide Mixture Induces Accelerated Mesenchymal Stem Cell Aging In Vitro
Authors: Leveque Xavier , Hochane Mazene , Geraldo Fanny , Dumont Solene , Gratas Catherine , Oliver Lisa , Gaignier Claire , Trichet Valérie , Layrolle Pierre , Heymann Dominique , Herault Olivier , Vallette François M. , Olivier Christophe 
Published: April 2019

Abstract
The general population is chronically exposed to multiple environmental contaminants such as pesticides. We have previously demonstrated that human mesenchymal stem cells (MSCs) exposed in vitro to low doses of a mixture of seven common pesticides showed a permanent phenotype modification with a specific induction of an oxidative stress-related senescence. Pesticide mixture also induced a shift in MSC differentiation toward adipogenesis. Thus, we hypothesized that common combination of pesticides may induce a premature cellular aging of adult MSCs. Our goal was to evaluate if the prolonged exposure to pesticide mixture could accelerate aging-related markers and in particular deteriorate the immunosuppressive properties of MSCs. MSCs exposed to pesticide mixture, under long-term culture and obtained from aging donor, were compared by bulk RNA sequencing analysis. Aging, senescence, and immunomodulatory markers were compared. The protein expression of cellular aging-associated metabolic markers and immune function of MSCs were analyzed. Functional analysis of the secretome impacts on immunomodulatory properties of MSCs was realized after 21 days' exposure to pesticide mixture. The RNA sequencing analysis of MSCs exposed to pesticide showed some similarities with cells from prolonged culture, but also with the MSCs of an aged donor. Changes in the metabolic markers MDH1, GOT and SIRT3, as well as an alteration in the modulation of active T cells and modifications in cytokine production are all associated with cellular aging. A modified functional profile was found with similarities to aging process. Stem Cells 2019;37:1083–1094
p53-TP53-Induced Glycolysis Regulator Mediated Glycolytic Suppression Attenuates DNA Damage and Genomic Instability in Fanconi Anemia Hematopoietic Stem Cells
Authors: Li Xue , Wu Limei , Zopp Morgan , Kopelov Shaina , Du Wei 
Published: April 2019

Abstract
Emerging evidence has shown that resting quiescent hematopoietic stem cells (HSCs) prefer to utilize anaerobic glycolysis rather than mitochondrial respiration for energy production. Compelling evidence has also revealed that altered metabolic energetics in HSCs underlies the onset of certain blood diseases; however, the mechanisms responsible for energetic reprogramming remain elusive. We recently found that Fanconi anemia (FA) HSCs in their resting state are more dependent on mitochondrial respiration for energy metabolism than on glycolysis. In the present study, we investigated the role of deficient glycolysis in FA HSC maintenance. We observed significantly reduced glucose consumption, lactate production, and ATP production in HSCs but not in the less primitive multipotent progenitors or restricted hematopoietic progenitors of Fanca−/− and Fancc−/− mice compared with that of wild-type mice, which was associated with an overactivated p53 and TP53-induced glycolysis regulator, the TIGAR-mediated metabolic axis. We utilized Fanca−/− HSCs deficient for p53 to show that the p53-TIGAR axis suppressed glycolysis in FA HSCs, leading to enhanced pentose phosphate pathway and cellular antioxidant function and, consequently, reduced DNA damage and attenuated HSC exhaustion. Furthermore, by using Fanca−/− HSCs carrying the separation-of-function mutant p53R172P transgene that selectively impairs the p53 function in apoptosis but not cell-cycle control, we demonstrated that the cell-cycle function of p53 was not required for glycolytic suppression in FA HSCs. Finally, ectopic expression of the glycolytic rate-limiting enzyme PFKFB3 specifically antagonized p53-TIGAR-mediated metabolic reprogramming in FA HSCs. Together, our results suggest that p53-TIGAR metabolic axis-mediated glycolytic suppression may play a compensatory role in attenuating DNA damage and proliferative exhaustion in FA HSCs. Stem Cells 2019;37:937–947
Use of Drones in Fishery Science
Authors: Harris J. Mason , Nelson James A. , Rieucau Guillaume , Broussard Whitney P. 
Published: April 2019

AbstractThe use of unmanned aircraft systems (UASs), commonly referred to as drones, has rapidly expanded across many scientific disciplines. Like other fields, fisheries research would benefit significantly from broader use of this emerging technology but has lagged behind other disciplines. Like the implementation of satellite and aircraft‐based remote sensing technology in previous decades brought a greater understanding of large‐scale spatial patterns and processes, UAS technology has the potential to put those tools in the hands of individual researchers, allowing implementation at finer spatial and temporal scales for a fraction of the cost. Our goal is to provide a “how‐to” for fisheries researchers interested in using UAS technology. We outline the necessary steps for any UAS project from choosing the appropriate platform and sensors to data acquisition and analysis. We also present the current ways in which UASs are being used in a fisheries research context as well as potential future research directions.
Reviewing benefits and costs of hydropower development evidence from the Lower Mekong River Basin
Authors: Intralawan Apisom , Smajgl Alex , McConnell William , Ahlquist Daniel B. , Ward John , Kramer Daniel B. 
Published: April 2019

In this paper, we examine the benefits and costs of hydropower development in the Mekong River Basin. We compare four major reports—the Mekong River Commission's (MRC's) Basin Development Plan Programme, Phase 2 (BDP2), the Strategic Environmental Assessment of Hydropower on the Mekong Mainstream (SEA), the Study on the Impacts of Mainstream Hydropower on the Mekong River (MDS), and the MRC's recent council study (CS)—in order to provide the basis for a comparative analysis of the major impact evaluation literature on mainstream dam construction in the Mekong River Basin for the period of 2010–2018. The primary objective of the review is to identify points of agreement, disagreement, inconsistency, and knowledge gaps. Both Mekong River Commission reports (BDP2 and CS) suggest extensive economic benefits for proposed hydropower development, whereas the SEA and MDS indicate that the net impact would be negative. The projected impacts of hydropower development on fisheries, sediment flows, and ecosystems vary widely both in economic and biophysical terms. However, all four reports point to decreased food security and loss of local livelihoods for millions of people as major concerns related to dam development. While considerable resources have been devoted to producing these important studies, the lack of standardization across reports, especially assumptions and methodologies for economic impacts, frustrates efforts at meaningful comparison of their findings and precludes the prospect of clear analytical outcomes or policy impacts.This article is categorized under:

Engineering Water > Planning Water
Human Water > Value of Water
Engineering Water > Methods
Neuromorphic vision: From sensors to event‐based algorithms
Authors: Lakshmi Annamalai , Chakraborty Anirban , Thakur Chetan S. 
Published: April 2019

Regardless of the marvels brought by the conventional frame‐based cameras, they have significant drawbacks due to their redundancy in data and temporal latency. This causes problem in applications where low‐latency transmission and high‐speed processing are mandatory. Proceeding along this line of thought, the neurobiological principles of the biological retina have been adapted to accomplish data sparsity and high dynamic range at the pixel level. These bio‐inspired neuromorphic vision sensors alleviate the more serious bottleneck of data redundancy by responding to changes in illumination rather than to illumination itself. This paper reviews in brief one such representative of neuromorphic sensors, the activity‐driven event‐based vision sensor, which mimics human eyes. Spatio‐temporal encoding of event data permits incorporation of time correlation in addition to spatial correlation in vision processing, which enables more robustness. Henceforth, the conventional vision algorithms have to be reformulated to adapt to this new generation vision sensor data. It involves design of algorithms for sparse, asynchronous, and accurately timed information. Theories and new researches have begun emerging recently in the domain of event‐based vision. The necessity to compile the vision research carried out in this sensor domain has turned out to be considerably more essential. Towards this, this paper reviews the state‐of‐the‐art event‐based vision algorithms by categorizing them into three major vision applications, object detection/recognition, object tracking, localization and mapping.This article is categorized under:
Technologies > Machine Learning
Therapie der akuten diabetischen Stoffwechselentgleisungen bei Erwachsenen (Update 2019)
Authors: Kaser Susanne , Sourij Harald , Clodi Martin , Schneeweiß Bruno , Laggner Anton N. , Luger Anton 
Published: April 2019

Zusammenfassung
Akute Stoffwechselentgleisungen können für Erwachsene in Abhängigkeit von ihrem Ausmaß lebensbedrohlich sein. Dementsprechend sind eine rasche umfassende Diagnostik und Therapie sowie eine enge Überwachung der Vitalparameter und Laborbefunde erforderlich. Bei der Therapie, die sich bei der ketoazidotischen (DKA) und hyperglykämisch-hyperosmolaren (HHS) Form nicht wesentlich unterscheidet, kommt dem Ausgleich des meist beträchtlichen Flüssigkeitsdefizits mit mehreren Litern einer physiologischen kristalloiden Lösung eine vorrangige Rolle zu. Bei den Elektrolyten ist insbesondere auf eine ausgeglichene Serum-Kalium-Konzentration zu achten. Normal-Insulin oder rasch wirksame Analoga können initial als i.v.-Bolus verabreicht werden, in der Folge jedoch kontinuierlich über einen Perfusor. Die Umstellung auf eine subkutane Insulintherapie soll erst bei ausgeglichenem Säure-Basen-Haushalt und zufriedenstellender Glykämie erfolgen.