bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of Malaria in the First Trimester of Pregnancy on Poor Maternal and Birth Outcomes in Benin
Authors: Accrombessi Manfred , Yovo Emmanuel , Fievet Nadine , Cottrell Gilles , Agbota Gino , Gartner Agnès , Martin-Prevel Yves , Vianou Bertin , Sossou Darius , Fanou-Fogny Nadia , Djossinou Diane , Massougbodji Achille , Cot Michel , Briand Valérie 
Published: December 2018

Abstract

Background
In sub-Saharan Africa, malaria in the first half of pregnancy is harmful for both the mother and her fetus. However, malaria in the first trimester of pregnancy, when women are usually not protected against malaria, has been little investigated. For the first time, we assessed the effects of malaria in the first trimester on maternal and birth outcomes using a preconceptional study design.

Methods
From June 2014 to March 2017, 1214 women of reproductive age were recruited and followed monthly until 411 became pregnant. The pregnant women were then followed from 5–6 weeks of gestation until delivery. Path analysis was used to assess the direct effect (ie, not mediated by malaria in the second or third trimester) of malaria in the first trimester on maternal anemia and poor birth outcomes. The cumulative effect of infections during pregnancy on the same outcomes was also evaluated.

Results
The prevalence of malaria infections in the first trimester was 21.8%. Malaria in the first trimester was significantly associated with maternal anemia in the third trimester (adjusted odds ratio 2.25, 95% confidence interval 1.11–4.55). While we did not find evidence of any direct effect of first trimester malaria infections on birth outcomes, their association with infections later in pregnancy tended to increase the risk of low birth weights.

Conclusions
Malaria infections in the first trimester were highly prevalent and have deleterious effects on maternal anemia. They highlight the need for additional preventive measures, starting in early pregnancy or even before conception.
The Role of Construal Level in Message Effects Research: A Review and Future Directions
Authors: Lee Stella Juhyun 
Published: December 2018

Abstract
Construal level theory is a recent psychological theory that examines the relationship between psychological distance and mental construal. However, the theory’s implications for message effects research requires more attention. Construal level theory can guide new hypotheses that test the persuasiveness of certain combinations of message features and tailoring messages to different individual orientations. This is possible as the theory may reveal underlying similarities across disparate message topics, design elements, and message processing styles. Core principles of construal level theory are explicated, and message effects research areas that may benefit from its propositions are reviewed and elaborated upon. Finally, caveats of applying the theory to message effects research and future directions are discussed.
Analysis of hidradenitis suppurativa–linked mutations in four genes and the effects of PSEN1-P242LfsX11 on cytokine and chemokine expression in macrophages
Authors: Li Airong , Peng Yang , Taiclet Lauren M , Tanzi Rudolph E 
Published: December 2018

Abstract
Hidradenitis suppurativa (HS), or acne inversa, is a chronic inflammatory skin disorder characterized clinically with acne-like lesions in apocrine gland–bearing skin, follicular occlusion and recurrent inflammation. Thirty-four unique mutations in patients with HS have been found in three genes encoding the γ-secretase complex: nicastrin (NCSTN), presenilin 1 (PSEN1), presenilin enhancer 2 (PSENEN) and in POGLUT1, an endoplasmic reticulum O-glucosyltransferase involved in Notch signaling. We have carried out a system review and have performed a functional analysis of the 34 unique reported HS-linked mutations in NCSTN, PSEN1, PSENEN and POGLUT1. We have also examined the effects of the HS-linked PSEN1-P242LfsX11 mutation on cytokine and chemokine expression in macrophages. Mutations in NCSTN are predicted to cause loss of function, to result in loss of transmembrane (TM) domain, to affect NCSTN substrate recruitment sites, to cause loss or creation of new ligand binging sites and to alter post-translational modifications and disulfide bonds. PSEN1-P242LfsX11 occurs at the opposite side of TM5 from Alzheimer’s disease–linked PSEN1 mutations. All of the PSENEN mutations occur on TM regions that are predicted to disrupt membrane function. POGLUT1 mutations lead to an early termination of protein synthesis and are predicted to affect ligand binding function. In addition, PSEN1-P242LfsX11 mediates cytokine and chemokine expression and prolongs tumor necrosis factor α production on the inflammatory processes in THP-1 cells and phorbol-12-myristate-13-acetate–differentiated macrophages in response to lipopolysaccharide stimulation. These in silico analyses are instructive for functional studies of the HS-linked mutations. The PSEN1-P242LfsX11 mutation mediates cytokine and chemokine expression in macrophages.
Evolution Equations for Non-Degenerate 2-Forms
Authors: He Weiyong 
Published: December 2018

AbstractIn this paper we introduce several geometric flows that evolve primarily non-degenerate 2-forms, with the motivation to develop a geometric flow to approach the existence of the symplectic forms on a compact manifold that supports a non-degenerate 2-form. In particular, we introduce $\mathrm{d}^{\ast }\mathrm{d}$-flow and $\mathrm{d}^{\ast }\mathrm{d}$-Ricci flow for a compatible pair $(\omega , J)$ of an almost Hermitian structure. We prove the short time existence and uniqueness of these flows with smooth initial data, and give some examples of long time existence and convergence.
Reduction Techniques for Young Femoral Neck Fractures
Authors: Halvorson Jason 
Published: December 2018

Summary:
Young femoral neck fractures remain challenging fractures to treat. Reduction has repeatedly been shown to be the single most important determinant of patient outcome, and treating surgeons should do all they can to achieve anatomic reduction because this is an outcome variable within the surgeon's control. Whether an open or closed reduction is performed, we hope to provide the reader with reduction strategies when faced with this difficult fracture pattern. In addition, we hope to review indications and techniques for using the various treatment implants/modalities that are currently available as they pertain to reduction and fixation.
Evolutionary games with environmental feedbacks
Authors: Tilman Andrew R. , Plotkin Joshua , Akçay Erol 
Published: December 2018

AbstractStrategic interactions form the basis for evolutionary game theory and often occur in dynamic environments. The various strategies employed in a population may alter the quality or state of the environment, which may in turn feedback to change the incentive structure of strategic interactions. This type of feedback is common in social-ecological systems, evolutionary-ecological systems, and even psychological-economic systems – where the state of the environment alters the dynamics of competing types, and vice versa. Here we develop a framework of “eco-evolutionary game theory” that permits the study of joint strategic and environmental dynamics, with feedbacks. We consider environments governed either by a renewable resource (e.g. common-pool harvesting) or a decaying resource (e.g. pollution byproducts). We show that the dynamics of strategies and the environment depend, crucially, on the incentives for individuals to lead or follow behavioral changes, and on the relative speed of environmental versus strategic change. Our analysis unites dynamical phenomena that occur in settings as diverse as human decision-making, plant nutrient acquisition, and resource harvesting. We discuss the implication of our results for fields ranging from ecology to economics.
Loss of Sarm1 non-autonomously protects Schwann cells from chemotoxicity
Authors: Tian Weili , Czopka Tim , López-Schier Hernán 
Published: December 2018

ABSTRACTThe obligate pro-degenerative protein Sarm1 is essential for Wallerian axon degeneration. Inhibition of Sarm1 has been proposed as a promising neuroprotective strategy with clinical relevance. Yet, the conditions that will most benefit from inhibiting Sarm1 remain undefined. Here we use genetics and pharmacology in zebrafish to show that systemic elimination of Sarm1 is glioprotective. Loss of Sarm1 does not affect macrophage recruitment to the wound microenvironment, focal injury resolution, or nerve repair. Unexpectedly, Sarm1 deficiency increases Schwann-cell resistance to toxicity by diverse chemotherapeutic agents after neuronal injury. Yet, synthetic degradation of Sarm1-deficient severed axons reversed this effect, suggesting that glioprotection is non-cell-autonomous. These findings anticipate that interventions aimed at inhibiting Sarm1 can counter heightened glial vulnerability to chemical stressors and may be an effective strategy to reduce chronic consequences of neurotrauma.
pcaExplorer: an R/Bioconductor package for interacting with RNA-seq principal components
Authors: Marini Federico , Binder Harald 
Published: December 2018

AbstractBackgroundPrincipal component analysis (PCA) is frequently useentirely written ind in genomics applications for quality assessment and exploratory analysis in high-dimensional data, such as RNA sequencing (RNA-seq) gene expression assays. Despite the availability of many software packages developed for this purpose, an interactive and comprehensive interface for performing these operations is lacking.ResultsWe developed the pcaExplorer software package to enhance commonly performed analysis steps with an interactive and user-friendly application, which provides state saving as well as the automated creation of reproducible reports. pcaExplorer is implemented in R using the Shiny framework and exploits data structures from the open-source Bioconductor project. Users can easily generate a wide variety of publication-ready graphs, while assessing the expression data in the different modules available, including a general overview, dimension reduction on samples and genes, as well as functional interpretation of the principal components.ConclusionpcaExplorer is distributed as an R package in the Bioconductor project (http://bioconductor.org/packages/pcaExplorer/), and is designed to assist a broad range of researchers in the critical step of interactive data exploration.
Resolving cell cycle speed in one snapshot with a live-cell fluorescent reporter
Authors: Eastman Anna E. , Chen Xinyue , Hu Xiao , Hartman Amaleah A. , Pearlman Morales Aria M. , Yang Cindy , Lu Jun , Kueh Hao Yuan , Guo Shangqin 
Published: December 2018

SummaryCell proliferation changes concomitantly with fate transitions during reprogramming, differentiation, regeneration, and oncogenesis. Methods to resolve cell cycle length heterogeneity in real-time are currently lacking. Here, we describe a genetically encoded fluorescent reporter that captures live cell cycle speed using a single measurement. This reporter is based on the color-changing Fluorescent Timer (FT) protein, which emits blue fluorescence when newly synthesized before maturing into a red fluorescent protein. We generated a mouse strain expressing an H2B-FT fusion reporter from a universally active locus, and demonstrate that faster-cycling cells can be distinguished from slower-cycling ones based on the intracellular fluorescence ratio between the FT’s blue and red states. Using this reporter, we reveal the native cell cycle speed distributions of fresh hematopoietic cells, and demonstrate its utility in analyzing cell proliferation in solid tissues. This system is broadly applicable for dissecting functional heterogeneity associated with cell cycle dynamics in complex tissues.
Estimating the built environment stock in Cape Verde
Authors: Lopes Jorge Pedro , Oliveira Rui Alexandre , Abreu Maria Isabel 
Published: December 2018

Purpose
The purpose of this paper is to present the estimates of the value of the built environment stock in Cape Verde, a Sub-Saharan African country that is scattered through ten relatively small islands.

Design/methodology/approach
It applies the perpetual inventory method in a long series of construction investment data at 1980 and 2007 constant prices published by the Cape Verde’s National Statistics Office.

Findings
The results show that the capital-output ratio is similar to those in the advanced industrial countries. The high value of this indicator suggests that the country should shift its focus from building new investment projects to managing the considerable amount of built stock.

Originality/value
The main originality of the paper comes from the use of different data sets from the National Statistical Office to construct the indicators of the construction industry activity in a comprehensive way.
MHD mixed convection of nanofluid due to an inner rotating cylinder in a 3D enclosure with a phase change material
Authors: Chamkha Ali J. , Selimefendigil Fatih 
Published: December 2018

Purpose
The purpose of this study is to numerically examine the mixed convection of CuO-water nanofluid due to a rotating inner hot circular cylinder in a 3D cubic enclosure with phase change material (PCM) attached to its vertical surface. Heat transfer and fluid flow characteristics were examined for various values of pertinent parameters.

Design/methodology/approach
Finite element method was used in the numerical simulation. Influence of various pertinent parameters such as Rayleigh number (between 10$^5$ and 10$^6$), Hartmann number (between 0 and 100), angular rotational speed of the cylinder (between −50 and 50), solid nanoparticle volume fraction (between 0 and 0.04) and PCM parameters (height-between 0.2H and 0.8H, thermal conductivity ratio- between 0.1 and 10) on the convective heat transfer characteristics are numerically studied.

Findings
It was observed that local heat transfer variations along the hot surface differ significantly for the cases with and without magnetic field where three distinct hot spots of peak Nusselt number are established when magnetic field is imposed. The average Nusselt number enhancement with the nanofluid at the highest particle volume fraction is 52.85 per cent at Hartmann number of 100, whereas its value is 39.76 per cent for the case in the absence of magnetic field. When the inner cylinder rotates, flow and thermal fields are affected within the cavity. The local heat transfer variations spread over the hot surface with cylinder rotation and 16.43 per cent of reduction in the average heat transfer is obtained with counter-clockwise rotation at 100 rad/sec. An enhancement in the PCM height and a reduction in the thermal conductivity of the PCM result in average heat transfer deterioration for the 3D cavity. The amount of the reduction is 43 per cent when the PCM height is increased from 0.2H to 0.8H, whereas 19.10 per cent enhancement in the heat transfer is achieved when thermal conductivity ratio (PCM) to the base fluid is increased from 0.1 to 10.

Originality/value
Such configurations can be designed for convection control, and in our case, various methods are available. Some of the investigated methods can be used in applications where magnetic field already exists. Convection control study in 3D cavity gives more realistic results as compared to 2D configurations, and results of the current investigation may be used for the design, optimization and flow control of many thermal applications involving magnetic field effects.
Supervisor support and turnover in hotels
Authors: Gordon Susan , Tang Chun-Hung (Hugo) , Day Jonathon , Adler Howard 
Published: December 2018

PurposeThis paper aims to examine whether employee subjective well-being acts as a mediator in the relationship between perceived supervisor support and turnover intention within the context of select-service hotels.Design/methodology/approachThe sample included hourly employees in select-service hotels in the Midwest USA. The significance of the relationships was assessed using regression, and both the Sobel test and bootstrapping methods were performed to test the mediating effect of subjective well-being on the relationship between perceived supervisor support and turnover intention.FindingsThe results confirm subjective well-being acted as a partial mediator in the relationship between supervisor support and turnover intention. Employees who perceive higher levels of support from their supervisors are less likely to leave their organizations. At the same time, supervisor support also positively affects subjective well-being, which reduces turnover intention.Practical implicationsActions by supervisors’ impact the well-being of their employees, which in turn may influence whether an employee stays with the organization. Organizations could use management training and employee feedback on supervisor support to improve employee support mechanisms. Organizations should also pay attention to improving employee subjective well-being beyond the work place. Improving the well-being of employees and supporting employees can help reduce turnover and may increase employee satisfaction, guest satisfaction and profits.Originality/valueThis study is the first to show that subjective well-being mediates the relationship between supervisor support and turnover intention; and one of the few within the hospitality context to examine the constructs of subjective well-being, supervisor support and turnover together.
The use of poly(amido)amine dendrimer in modification of cotton for improving dyeing properties of acid dye
Authors: Patil Ashwini A. , Maiti Saptarshi , Adivarekar Ravindra V. 
Published: December 2018

PurposeCotton being an anionic fiber can be dyed with direct, reactive, vat and sulfur dyes but cannot be dyed with acid dyes due to their chemical differences. But there are certain advantages of acid dyes like acid dyeing is the simplest method than the other classes of dyes; and it offers various intense and bright shades. So, the purpose of this paper is to focus on acid dyeing of cotton fabric after its chemical modification.Design/methodology/approachSuch modification of cotton fabric has been achieved using poly(amido)amine dendrimer (PAMAM) treatment. The current work is based on the synthesis of a full-generation PAMAM dendrimer (G0) and its application onto the cotton fabric for modifying the cotton substrate by the exhaust and padding method.FindingsThe treatment of the dendrimer on cotton fabric has been analyzed by Fourier transform infrared spectroscopy and scanning electron microscopy. The dyeing results in terms of color strength of the treated cotton fabrics are compared with those of conventional acid dyed silk fabric. The fastness assessments such as wash, light and rubbing fastnesses after dyeing of treated cotton fabrics are also performed and found to be satisfactory.Originality/valueThis paper can be used in the application of synthesized poly(amido)amine dendrimer in acid dyeing of cotton.
Impact of wash types and stitching parameters on shrinkage of knitwear made from pique fabric
Authors: Ramzan Muhammad Babar , Rasheed Abher , Ali Zulfiqar , Ahmad Sheraz , Naeem Muhammad Salman , Afzal Ali 
Published: December 2018

PurposeIn the field of knitwear, dimensional stability is assumed as a critical problem that affects the quality and salability of a product. Although much work has been done in this area with a focus on the factors affecting fabric shrinkage, however, there is a lack of work on knitwears with respect to their dimensional stability. The purpose of this paper is to investigate the impact of stitching parameters and wash types on the dimensional properties of knitwear.Design/methodology/approachThe crew-neck t-shirts were prepared by using pique knitted fabrics. Different sewing and finishing parameters were used that include stitch density, stitch type, stitching thread and wash type. The critical measurements of the selected garment are taken as output variables which are body width, sleeve length, body length and across shoulder. After laundering process, shrinkage percentage was calculated by using before-wash and after-wash measurements.FindingsThis study shows that the stitching parameters affect significantly on knitwear’s shrinkage. Thus, when patterns are being developed for the cutting of fabric, expected shrinkage, known as residual shrinkage, must be considered to avoid unexpected changes in garment shape.Originality/valueThis research will be useful for knitwear manufacturing industry.
Critical drivers (CDs) of value management adoption in the Nigerian construction industry
Authors: Ojo Lekan Damilola , Ogunsemi Deji Rufus 
Published: December 2018

PurposeThis paper aims to assess the drivers of value management (VM) in the Nigerian construction industry with a view to identify the critical ones through Delphi study.Design/methodology/approachA team of 15 carefully selected experts in VM were engaged in two rounds of Delphi survey, and the responses of the survey were analyzed with descriptive statistics (mean, standard deviation and mode). Kendall’s coefficient of concordance test and Chi-square (χ2) test were also used to test the level of consensus amongst the respondents at the two rounds of the survey to draw inference. Interrater agreement analysis and significant level analysis were further used to determine the criticality of critical drivers.FindingsThe critical drivers to VM adoption are adequate understanding of the benefits of VM, higher/postgraduate programme that teaches VM technique, professional’s previous experience with VM, collaboration of all construction professional bodies in Nigeria and VM training.Originality/valueThis paper used opinions of VM experts only to achieve the aim of this study as against the common survey method in which respondents who are not knowledgeable in the area of research might fill the questionnaire.
Cognitive absorption and behavioural intentions in virtual health communities
Authors: Mpinganjira Mercy 
Published: December 2018

PurposeThis paper aims to provide a conceptual model that elucidates the role of cognitive absorption in explaining behavioural intentions in virtual health communities.Design/methodology/approachData were collected from 361 contributing members of virtual health communities from Gauteng, South Africa, using a structured questionnaire. Structural equation modelling using AMOS software was used to analyse the data.FindingsThe findings show that cognitive absorption has a significant direct positive influence on content posters’ intentions to continue participating on virtual health community platforms. Cognitive absorption was also found to have an indirect influence on behavioural intentions through its influence on members’ attitude. It was also found to play a mediating role in the influence of perceived usefulness and behavioural intention.Research limitations/implicationsThe study shows the value of linking flow theory and the technology acceptance model to provide a comprehensive understanding of behavioural intentions in virtual health community forums.Practical implicationsManagers of virtual health communities need to pay attention to experiential aspects of their sites. Success in ensuring that community members are cognitively absorbed is key to the development of positive attitude and intentions towards virtual health community forums.Originality/valueVirtual health communities play a new and growing role in the way health-related information and support is offered and accessed by those in need. Despite their importance, not much research has been done to explain the role of consumer experience in member behavioural intentions on such forums. The study contributes to this understanding by demonstrating the value of cognitive absorption in directly explaining users’ attitude and behavioural intentions. The study also sheds light on the role played by cognitive absorption in explaining the influence of perceived usefulness on behavioural intentions.