bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association between J‐CTO score and long‐term target lesion revascularization rate after successful chronic total coronary occlusion angioplasty (from the J‐CTO Registry)
Authors: Abe Mitsuru , Morimoto Takeshi , Morino Yoshihiro , Tanaka Hiroyuki , Akao Masaharu , Hayashi Yasuhiko , Muramatsu Toshiya , Ochiai Masahiko , Noguchi Yuichi , Yumoto Kazuhiko , Shibata Yoshisato , Hiasa Yoshikazu , Doi Osamu , Yamashita Takehiro , Hinohara Tomoaki , Kadota Kazushige , Kimura Takeshi ,   For the J‐CTO Registry Investigators
Published: February 2019

AbstractObjectivesThe aim of this study was to evaluate the impact of the J‐CTO score on long‐term target lesion revascularization (TLR) after successful native chronic total occlusion (CTO)‐percutaneous coronary intervention (PCI).BackgroundWe previously reported that the J‐CTO score could be used to stratify the lesion complexity and procedural success rate in CTO lesions.MethodsWe evaluated the prognostic significance of a high J‐CTO score for long‐term TLR rate in the J‐CTO Registry.ResultsIn the 425 lesions of 408 patients who underwent successful CTO‐PCI during a median follow‐up of 63.0 (interquartile range: 21.2–72.9) months in the J‐CTO Registry, the cumulative incidence of TLR of lesions with a J‐CTO score ≥ 2 (n = 216) was significantly higher than in those with a J‐CTO score ≤ 1 (n = 209) (27.0 versus 19.4% at 5 years, respectively, P = 0.04). Among 323 lesions of 309 patients with a complete 5‐year follow‐up, the rate of TLR was 28% (n = 91). A J‐CTO score ≥ 2 was independently associated with a higher risk of TLR (odds ratio, 1.73; 95% confidence interval, 1.01–2.99, P = 0.048) even after adjustment for clinically relevant baseline factors.ConclusionsPatients with high J‐CTO score lesions had a higher 5‐year risk of TLR.
Feasibility and safety of jailed‐pressure wire technique using durable optical fiber pressure wire for intervention of coronary bifurcation lesions
Authors: Omori Hiroyuki , Kawase Yoshiaki , Hara Masahiko , Tanigaki Toru , Okamoto Shuuichi , Hirata Tetsuo , Kikuchi Jun , Ota Hideaki , Sobue Yoshihiro , Miyake Taiji , Kawamura Itta , Okubo Munenori , Kamiya Hiroki , Tsuchiya Kunihiko , Suzuki Takahiko , Pijls Nico H.J. , Matsuo Hitoshi 
Published: February 2019

AbstractObjectivesThe objective was to evaluate the safety, feasibility, and accuracy of the jailed‐pressure wire technique using a durable optical fiber‐based pressure wire with high‐pressure dilatation using a non‐compliant balloon after main vessel stenting.BackgroundFractional flow reserve (FFR) information can help interventionists determine whether they should treat a jailed‐side branch (SB). However, re‐crossing a pressure wire into a jailed‐SB is sometimes technically difficult.MethodsFifty‐one consecutive lesions from 48 patients who underwent the jailed‐pressure wire technique were retrospectively investigated. The primary endpoint was complication rate and secondary endpoints included success rate of FFR measurement, incidence of wire disruption, and final drift rate. The usability of FFR for percutaneous coronary intervention of coronary bifurcation lesion was also evaluated.ResultsMedian age of the patients was 69 years and 80.4% were men. The most frequent underlying disease was stable angina (70.6%) and 68.6% were type B2 lesions. Our main findings were: the procedure was performed successfully in all cases without any complications or wire disruption, FFR could be measured without significant final drift in 95.9% of cases, and FFR measurements helped interventionists determine whether to perform a final kissing balloon dilatation in 49.0% cases.ConclusionsThe jailed‐pressure wire technique using a durable optical fiber‐based pressure wire with high‐pressure post‐dilatation maneuver was safe, feasible, and accurate.
Culture‐negative group B streptococcal pericarditis: A case report and literature review of the diagnostic use of polymerase chain reaction
Authors: Tsushima Takahiro , Ishii Natsuko , Matsuzaka Suguru , Armitage Keith , Ohkusu Kiyofumi , Cammack Ivor , Yamada Akira , Mori Yuichiro , Sasaki Shunsuke , Hayashi Kentaro , Serizawa Yoshimoto 
Published: February 2019

Key Clinical MessageAlthough conventional microbiology cultures may be negative, polymerase chain reaction (PCR) can effectively identify both typical and atypical microorganisms. With careful interpretation, PCR could become the gold‐standard diagnostic test for culture‐negative bacterial pericarditis.
Myocardial infarction with simultaneous anterior and inferior ST‐segment elevation
Authors: Kristensen Anna Meta Dyrvig , Amin Sanaz , Byrne Christina , Pareek Manan 
Published: February 2019

Key Clinical MessageInfarction of the anterior myocardial wall results in anterior ST‐elevation. However, ST‐deviation may also appear inferiorly and may aid in localizing the culprit lesion.
Moth pheromone‐selective projection neurons with cell bodies in the antennal lobe lateral cluster exhibit diverse morphological and neurophysiological characteristics
Authors: Lee Seong‐Gyu , Celestino Christine Fogarty , Stagg Jeffrey , Kleineidam Christoph , Vickers Neil J. 
Published: February 2019

AbstractOlfactory projection neurons convey information from the insect antennal lobe (AL) to higher brain centers. Previous reports have demonstrated that pheromone‐responsive projection neurons with cell bodies in the moth medial cell cluster (mcPNs) predominantly have dendritic arborizations in the sexually dimorphic macroglomerular complex (MGC) and send an axon from the AL to the calyces of the mushroom body (CA) as well as the lateral horn (LH) of the protocerebrum via the medial AL tract. These neurons typically exhibit a narrow odor tuning range related to the restriction of their dendritic arbors within a single glomerulus (uniglomerular). In this study, we report on the diverse physiological and morphological properties of a group of pheromone‐responsive olfactory projection neurons with cell bodies in the AL lateral cell cluster (MGC lcPNs) of two closely related moth species. All pheromone‐responsive lcPNs appeared to exhibit “basket‐like” dendritic arborizations in two MGC compartments and made connections with various protocerebral targets including ventrolateral and superior neuropils via projections primarily through the lateral AL tract and to a lesser extent the mediolateral antennal lobe tract. Physiological characterization of MGC lcPNs also revealed a diversity of response profiles including those either enhanced by or reliant upon presentation of a pheromone blend. These responses manifested themselves as higher maximum firing rates and/or improved temporal resolution of pulsatile stimuli. MGC lcPNs therefore participate in conveying diverse olfactory information relating to qualitative and temporal facets of the pheromone stimulus to a more expansive number of protocerebral targets than their mcPN counterparts.
Gold Nanorattles with Intense Raman In Silica Nanoparticles (Nano‐IRIS) as Multimodal System for Imaging and Therapy
Authors: Ahlawat Monika , Sarkar Ankita , Roy Shounak , Jaiswal Amit 
Published: February 2019

AbstractHybrid colloids consisting of silica coated plasmonic core‐shell metal nanoparticles have driven progress in plethora of applications and are under intense investigation in diverse fields of research. In this regard, we have designed a multifunctional nanocomposite consisting of 1,4‐benzenedithiol (BDT) tagged gold nanorattles (Au‐NRT) as core embedded within a solid silica shell with an additional mesoporous silica shell coating forming an “IRIS” like morphology, referred to as Nano‐IRIS. The nanorattle structure with a solid gold octahedron core and porous cubic gold shell serves as an excellent SERS probe due to the presence of intrinsic electromagnetic (EM) hot‐spots. The intelligent design of incorporating a solid SiO2 layer in the core‐shell Nano‐IRIS structure helped in incorporating two different imaging functionalities, namely SERS and fluorescence‐based bioimaging into a single nanoplatform, thereby imparting a multimodal imaging attribute to Nano‐IRIS. The solid SiO2 layer not only helped in keeping the Raman reporter intact in the pores of AuNRT but also maintained the distance between the gold surface and the fluorescent drug Doxorubicin (DOX) encapsulated inside the mSiO2 layer to achieve fluorescence imaging without quenching. Additionally, Nano‐IRIS also emerged as a drug delivery system demonstrating highly efficient concentration dependent chemotherapy via ROS production and oxidative DNA damage.
Secure communication in cognitive radio networks with untrusted AF relays
Authors: Sharma Shashibhushan , Dhar Roy Sanjay , Kundu Sumit 
Published: February 2019

SummaryIn this paper, two underlay based cognitive cooperative radio networks, each with one secondary source (SS), one secondary destination (SD), N untrusted secondary amplify and forward relays (USAFRs), one primary transmitter, and one primary receiver (PU‐RX), are considered for evaluating the secrecy performance. The SS sends the information to the SD in two time slots via multiple USAFRs in the absence of direct link between SS and SD. In the first time slot, SS and SD transmit the message and jamming signal to multiple USAFRs, respectively. In the second slot, a selected USAFR amplifies and forwards the combined received signals to the SD. The transmit powers of the secondary nodes are chosen so as to maintain the overall interference at PU‐RX below a specified limit. The transmit power of a selected USAFR is derived using the harvested energy from the RF signals of SS and SD. Two network scenarios of eavesdropping by USAFRs are studied: in one case, all USAFRs eavesdrop; while in the second case, only the selected USAFR eavesdrops the message during forwarding of the signal and power is allocated to secondary nodes on the basis of outage threshold of primary network. We investigate the secrecy outage probability (SOP) in both of the networks under several physical parameters. Analytical framework for evaluating SOP for both the cases are given while SOP in single integration form is given for the second case. MATLAB simulation results are presented for both the cases.
Patterns of sexual size dimorphism in stingless bees: Testing Rensch’s rule and potential causes in highly eusocial bees (Hymenoptera: Apidae, Meliponini)
Authors: Quezada‐Euán José Javier G. , Sanabria‐Urbán Salomón , Smith Corey , Cueva del Castillo Raúl 
Published: February 2019

AbstractEusocial insects offer a unique opportunity to analyze the evolution of body size differences between sexes in relation to social environment. The workers, being sterile females, are not subject to selection for reproductive function providing a natural control for parsing the effects of selection on reproductive function (i.e., sexual and fecundity selection) from other kinds of natural selection. Patterns of sexual size dimorphism (SSD) and testing of Rensch's rule controlling for phylogenetic effects were analyzed in the Meliponini or stingless bees. Theory predicts that queens may exhibit higher selection for fecundity in eusocial taxa, but contrary to this, we found mixed patterns of SSD in Meliponini. Non‐Meliponaspecies generally have a female‐biased SSD, while all analyzed species ofMeliponashowed a male‐biased SSD, indicating that the direction and magnitude of the selective pressures do not operate in the same way for all members of this taxon. The phylogenetic regressions revealed that the rate of divergence has not differed between the two castes of females and the males, that is, stingless bees do not seem to follow Rensch's rule (a slope >1), adding this highly eusocial taxon to the various solitary insect taxa not conforming with it. Noteworthy, whenMeliponawas removed from the analysis, the phylogenetic regressions for the thorax width of males on queens had a slope significantly smaller than 1, suggesting that the evolutionary divergence has been larger in queens than males, and could be explained by stronger selection on female fecundity only in non‐Meliponaspecies. Our results in the stingless bees question the classical explanation of female‐biased SSD via fecundity and provide a first evidence of a more complex determination of SSD in highly eusocial species. We suggest that in highly eusocial taxa, additional selection mechanisms, possibly related to individual and colonial interests, could influence the evolution of environmentally determined traits such as body size.
Phenotypic and genetic diversity in aposematic Malagasy poison frogs (genus Mantella)
Authors: Klonoski Karina , Bi Ke , Rosenblum Erica Bree 
Published: February 2019

AbstractIntraspecific color variation has long fascinated evolutionary biologists. In species with bright warning coloration, phenotypic diversity is particularly compelling because many factors, including natural and sexual selection, contribute to intraspecific variation. To better understand the causes of dramatic phenotypic variation in Malagasy poison frogs, we quantified genetic structure and color and pattern variation across three closely related species, Mantella aurantiaca, Mantella crocea, and Mantella milotympanum. Although our restriction site‐associated DNA (RAD) sequencing approach identified clear genetic clusters, they do not align with current species designations, which has important conservation implications for these imperiled frogs. Moreover, our results suggest that levels of intraspecific color variation within this group have been overestimated, while species diversity has been underestimated. Within major genetic clusters, we observed distinct patterns of variation including: populations that are phenotypically similar yet genetically distinct, populations where phenotypic and genetic breaks coincide, and populations that are genetically similar but have high levels of within‐population phenotypic variation. We also detected admixture between two of the major genetic clusters. Our study suggests that several mechanisms—including hybridization, selection, and drift—are contributing to phenotypic diversity. Ultimately, our work underscores the need for a reevaluation of how polymorphic and polytypic populations and species are classified, especially in aposematic organisms.
Electrochemical Monitoring of Methotrexate Anticancer Drug in Human Blood Serum by Using in situ Solvothermal Synthesized Fe3O4/ITO Electrode
Authors: El‐Said Waleed A. , Abdel‐Rahman Mona A. , Sayed Eman M. , Abdel‐Wahab Aboel‐Magd A. 
Published: February 2019

AbstractHere, we reported on a one‐step fabrication of magnetite Fe3O4 nanoparticles/indium tin oxide (ITO) electrode based on the direct growing of Fe3O4 nanoparticles on the ITO surface by using a solvothermal process. The modified electrode was used as electrochemical methotrexate (MTX) biosensor with high sensitivity based on cyclic voltammetry and square wave voltammetry techniques. The results demonstrated a linear relationship between the MTX concentration and its oxidation current peak over a wide range from 10−5 to 10−14 mole/L with a limit of detection of 0.4×10−15 M based on the square wave voltammetry (SWV) technique. In addition, Fe3O4/ITO electrode showed a good capability for measuring very low concentrations of MTX drug dissolved in human serum solution. Also, Fe3O4/ITO electrode was used for detecting MTX in blood serum samples collected from patients after their treatment with MTX. The prepared electrode showed the higher sensitivity that higher than the Viva‐E instrument, which opens the door for developing a cheap, simple and higher sensitive MTX sensor.
Sensitive detection of hydroxymethylcytosine levels in normal and neoplastic cells and tissues
Authors: Krais Annette M. , Park Yoon Jung , Reifenberger Guido , Meister Michael , Plass Christoph , Schmeiser Heinz H. 
Published: February 2019

AbstractA new sensitive analytical method using capillary electrophoresis with laser induced fluorescence (CE‐LIF) was applied for the simultaneous detection of DNA methylation and hydroxymethylation levels in human cancers of different origin. DNA hydroxymethylation, measured as 5‐hydroxymethylcytosine (5hmC) levels, was decreased in gliomas with mutation in the isocitrate dehydrogenase 1 (IDH1) gene when compared to IDH1‐wildtype gliomas. Independent from IDH1 mutation, 5hmC levels were decreased in lung carcinomas when compared to normal lung tissue. Reduced DNA hydroxymethylation was also observed upon dedifferentiation in cultured murine embryonic fibroblasts. Our data show that reduced DNA hydroxymethylation is related to cellular dedifferentiation and can be detected in various types of cancers, independent from the IDH1 mutation status. Quantitative determination of altered 5hmC levels may therefore have potential as a biomarker linked to cellular differentiation and tumorigenesis.
Randomized trial of add‐on triheptanoin vs medium chain triglycerides in adults with refractory epilepsy
Authors: Borges Karin , Kaul Neha , Germaine Jack , Kwan Patrick , O'Brien Terence J. 
Published: February 2019

SummaryObjectiveTo investigate the feasibility, safety, and tolerability of add‐on treatment of the triglycerides of heptanoate (triheptanoin) vs the triglycerides of octanoate and decanoate (medium chain triglycerides [MCTs]) in adults with treatment‐refractory epilepsy.MethodsAfter an 8‐week prospective baseline period, people with drug‐resistant epilepsy were randomized in a double‐blind fashion to receive triheptanoin or MCTs. Treatment was titrated over 3 weeks to a maximum of 100 mL/d to be distributed over 3 meals and mixed into food, followed by 12‐week maintenance before tapering. The primary aims were to assess the following: (a) safety by comparing the number of intervention‐related adverse events with triheptanoin vs MCT treatment and (b) adherence, measured as a percentage of the prescribed treatment doses taken.ResultsThirty‐four people were randomized (17 to MCT and 17 to triheptanoin). There were no differences regarding (a) the number of participants completing the study (11 vs 9 participants), (b) the time until withdrawal, (c) the total number of adverse events or those potentially related to treatment, (d) median doses of oils taken (59 vs 55 mL/d, P = 0.59), or (e) change in seizure frequency (54% vs 102%, P = 0.13). Please note that people with focal unaware seizures were underrepresented in the triheptanoin treatment arm (P = 0.04). The most common adverse events were gastrointestinal disturbances (47% and 62.5% of participants). Five people taking on average 0.73 mL/kg body weight MCTs (0.64 mL/kg median) and one person taking 0.59 mL/kg triheptanoin showed >50% reduction in seizure frequency, specifically focal unaware seizures.SignificanceAdd‐on treatment with MCTs or triheptanoin was feasible, safe, and tolerated for 12 weeks in two‐thirds of people with treatment‐resistant epilepsy. Our results indicate a protective effect of MCTs on focal unaware seizures. This warrants further study.
Individual goal‐oriented cognitive rehabilitation to improve everyday functioning for people with early‐stage dementia: A multicentre randomised controlled trial (the GREAT trial)
Authors: Clare Linda , Kudlicka Aleksandra , Oyebode Jan R. , Jones Roy W. , Bayer Antony , Leroi Iracema , Kopelman Michael , James Ian A. , Culverwell Alison , Pool Jackie , Brand Andrew , Henderson Catherine , Hoare Zoe , Knapp Martin , Woods Bob 
Published: February 2019

ObjectivesTo determine whether individual goal‐oriented cognitive rehabilitation (CR) improves everyday functioning for people with mild‐to‐moderate dementia.Design and methodsParallel group multicentre single‐blind randomised controlled trial (RCT) comparing CR added to usual treatment (CR) with usual treatment alone (TAU) for people with an ICD‐10 diagnosis of Alzheimer, vascular or mixed dementia, and mild‐to‐moderate cognitive impairment (Mini‐Mental State Examination [MMSE] score ≥ 18), and with a family member willing to contribute. Participants allocated to CR received 10 weekly sessions over 3 months and four maintenance sessions over 6 months. Participants were followed up 3 and 9 months post randomisation by blinded researchers. The primary outcome was self‐reported goal attainment at 3 months. Secondary outcomes at 3 and 9 months included informant‐reported goal attainment, quality of life, mood, self‐efficacy, and cognition and study partner stress and quality of life.ResultsWe randomised (1:1) 475 people with dementia; 445 (CR = 281) were included in the intention to treat analysis at 3 months and 426 (CR = 208) at 9 months. At 3 months, there were statistically significant large positive effects for participant‐rated goal attainment (d = 0.97; 95% CI, 0.75‐1.19), corroborated by informant ratings (d = 1.11; 95% CI, 0.89‐1.34). These effects were maintained at 9 months for both participant (d = 0.94; 95% CI, 0.71‐1.17) and informant (d = 0.96; 95% CI, 0.73‐1.2) ratings. The observed gains related to goals directly targeted in the therapy. There were no significant differences in secondary outcomes.ConclusionsCR enables people with early‐stage dementia to improve their everyday functioning in relation to individual goals targeted in the therapy.
Incorporation of Core‐Twisted Perylene Bisimide Ligands into a Discrete Cp*Rh‐Based Molecular‐Rectangle via Coordination‐Driven Self‐Assembly
Authors: Zhang Le , Das Rajorshi , Han Ying‐Feng 
Published: February 2019

AbstractA tetranuclear metallarectangle (2) derived from dinuclear rhodium(III) building block [Cp*2Rh2(μ‐η2‐η2‐C2O4)]Cl2 and imidazole‐based perylene bisimide ditopic ligand (1) (1=2,9‐bis(4‐(1H‐imidazol‐1‐yl)phenyl)‐5,6,12,13‐tetrachloroanthra‐[2,1,9‐def:6,5,10‐d′e′f′]diisoquinoline‐1,3,8,10(2H,9H)‐tetraone) in presence of silver triflate is reported. The self‐assembled metallarectangle 2 is fully characterized by NMR, ESI‐MS, UV‐vis absorption, fluorescence emission spectroscopy and cyclic voltammetry. The X‐ray diffraction analysis reveals a twisted conformational geometry of metallarectangle 2 caused by essential steric demands of the two side‐by‐side chlorine atoms. In addition, the analyzed structure also elaborates the intermolecular electrostatic interactions between the electron‐deficient diimide moiety of 2 and the electron‐rich planar phenanthrene molecule.