bluuebunny/crossref_metadata_2025_split huggingface dataset:
„Das Hoffen lernen“
Authors: Novkovic Dominik 
Published: November 2024

Zusammenfassung
Angesichts der periodisch variierenden Aufmerksamkeit für die distinkten Formen devianten Verhaltens im Kindes- und Jugendalter weist die Sozialpädagogik in ihren praktischen Interventionsverfahren und Deutungsmustern ein gravierendes Defizit an theoretischer und methodologischer Fundierung auf. Insbesondere die penetrante Expansion psychotherapeutisch-biologistisch-organpathologischer Diagnosemuster in Kombination mit einem pharmalogischen Behandlungsrepertoire wird problematisiert. Kontrastiert wird die bildungs- und gesellschaftstheoretische Abstinenz Sozialer Arbeit/Sozialpädagogik durch die in Ernst Blochs dialektisch-materialistischer «Philosophie des Neuen» angelegte genetische Erkenntnismethodik, die es ermöglicht, Devianz als gesellschaftliches Verhältnis zu problematisieren und dem Leidensdruck konkreter Individuen in einem durch Verteilungskonflikte und (vertikale) soziale Ungleichheit strukturierten Klassensystem gerecht zu werden. Der Beitrag zielt dabei auf eine sozialpädagogische Relektüre der Theoriekonzeption von Ernst Bloch. Die (theorie-)systematische Neuverortung und Einbeziehung seiner Überlegungen in den Kontext der jüngeren ideologischen und fachpolitischen Auseinandersetzung mit dem Devianzphänomen eröffnet einen kritischen Verstehensprozess. Im Horizont der Bloch´schen „Philosophie des Neuen“ wird ein sozialwissenschaftliches Forschungsdesign skizziert, welches für die Ausbruchs- und Artikulationsversuche vulnerabler kindlicher Subjekte sensibilisiert und damit für ein tiefergehendes Verständnis von Devianz unentbehrlich ist. Darüber hinaus soll gezeigt werden, dass die dem Bloch´schen Denkansatz inhärente hermeneutische Vorgehensweise neue Sozialbildungen im Sinne einer Emanzipatorik des Neuen erschließt. Abschließend wird in Anlehnung an das Denken Ernst Blochs ein Vorschlag für eine Sozialpädagogik der Hoffnung im Kontext der Devianzthematik unterbreitet.
Krisenerfahrung, Hoffnung und der utopische Raum transformatorischer Bildung
Authors: Eppenstein Thomas 
Published: November 2024

Zusammenfassung
Im Anschluss an das Konzept transformatorischer Bildung werden Chancen und Limitationen von Krisenerfahrungen in Hinblick auf Veränderungen des Bildungsgeschehens und des jeweiligen Selbst- und Weltverständnisses im Spannungsverhältnis von Hoffnung, konkreter Utopie (Ernst Bloch) und Sinnlosigkeit (Jean Améry) reflektiert. Ob eine Rezeption des Bloch’schen Verständnisses von ‚Hoffnung‘ als Referenz für eine auf Veränderung ausgerichtete Bildungsphilosophie und Bildungspraxis tauglich ist, bleibt am Ende kontingent; Mit den Reflexionen Jean Améry‘s über die Stellung des Intellektuellen in Auschwitz wird an ein Szenario erinnert, in dem Bildung zu etwas ganz und gar Irrealem wird. Daraus resultiert eine Absage an idealistische Bildungskonzeptionen und zugleich die Begründung für Bildungsanstrengungen, sinnlose Krisenerfahrungen, die stattgefunden haben, zu erinnern und im kulturellen Gedächtnis zu verankern.
Mathematical modeling for the potential energy of the aminophenol derivative azomethine molecule via Bezier surfaces and fuzzy inference system
Authors: Ermiş Temel 
Published: November 2024

Abstract
In this study, we have managed to model the energy surface of the aminophenol derivative azomethine molecule mathematically depending on two torsion angles SC1(C9C10C12N14) and SC2(C2C1C6C11). For this purpose, firstly, discrete data obtained from Density Functional Theory calculations have been converted into continuous data with the help of the Fuzzy Inference System. Thus, it is possible to calculate energy values for untested data, which are very costly in terms of time to obtain with other methods/experiments. Then, the continuous and non-smooth surface obtained from the fuzzy inference system and representing the energy values of the molecule has been transformed into a differentiable surface with the help of Bezier surfaces. Thus, an objective function has been obtained in which global optimization methods based on the derivative (or gradient) operator could be used.
miRNA-novel-216 regulated fatty acid composition and progesterone synthesis in goat granulosa cells by targeting the TPD52
Authors: Jia Yuhang , Xu Qiao , Wang Peng , Liu Ziyi , Zhang Runan , Liu Kai , Ling Yinghui , Liu Yufang , Chu Mingxing 
Published: November 2024

In briefSteroid hormone secretion by granulosa cells in the ovary is regulated by lipid synthesis and metabolism. This study found that miR-novel-216 affects granulosa cell proliferation and free fatty acid content by regulating TPD52 expression, thereby increasing the reproductive hormone secretion and promoting polytocous trait in goats.AbstractGranulosa cells in the ovaries of livestock are crucial for secreting steroid hormones that regulate follicular development, with lipid synthesis and metabolism playing key roles in this process. The molecular mechanisms behind steroid hormone secretion regulated by fatty acid metabolism in goat granulosa cells have been unclear. Our previous transcriptome analysis of Yunshang black goat ovaries revealed that miR-novel-216, which had lower expression in high-fertility goats, might regulate granulosa cell function. We further investigated the role of miR-novel-216 by isolating and culturing goat granulosa cells in vitro and found that it inhibits cell proliferation, lipid accumulation and progesterone synthesis in goat granulosa cells. The qTar and miRanda analyses predicted TPD52 as a target of miR-novel-216, confirmed by dual luciferase and transfection assays. Previous studies have shown that progesterone synthesis in granulosa cells is closely related to free fatty acid composition. We investigated the effect of in vitro construction of TPD52 overexpression and interference plasmids on the free fatty acid content of goat granulosa cells using mass spectrometry sequencing. The results showed that the overexpression of TPD52 in goat granulosa cells significantly increased the free fatty acid content and promoted granulosa cell proliferation, lipid accumulation and progesterone synthesis, whereas the opposite was true for inhibition of TPD52. It was shown that miR-novel-216 affects granulosa cell proliferation and free fatty acid levels by regulating the expression of TPD52, which increases reproductive hormone secretion and promotes polytocous trait in goats. This provides a foundation for developing breeding strategies to improve goat fertility.
Tecnologías de Información y Comunicación en odontólogos docentes
Authors: Parra-Gálvez Katherine Fiorella 
Published: November 2024

Objetivo. Determinar la frecuencia de uso de las Tecnologías de Información y Comunicación (TIC) en docentes de odontología de una universidad pública. Métodos. Este estudio fue de tipo cuantitativo, observacional, descriptivo y de corte transversal. La muestra fue conformada por 67 docentes en labor de la Facultad de Odontología de la Universidad Nacional Mayor de San Marcos, quienes fueron seleccionados mediante el muestreo aleatorio estratificado. Dichos maestros respondieron a un formulario virtual tipo encuesta con una escala de Likert, cuyo contenido fue el cuestionario validado Uso de TIC. Resultados. Se obtuvo que el uso de las Tecnologías de Información y Comunicación fue en su mayoría alto con un 74.63%, y solo se presentó un caso de bajo uso de dicha variable en el sexo masculino y a la vez perteneciente al grupo docente que tenía de 31 a 40 años de experiencia. Conclusiones. Los catedráticos de odontología tienen una frecuencia de uso favorable de las Tecnologías de Información y Comunicación en su práctica docente.
Efecto del sexo y variación individual sobre respuestas de comportamiento y desempeño de bovinos Simbrah
Authors: Grajales-Cedeño Joseph , Vargas Reynaldo , Ríos-Moreno Alex , Androli Mayara , Cedeño Héctor , Saavedra Roberto 
Published: November 2024

The aim of this study was to evaluate the effect of sex and individual variation on the behavioural responses and performance of Simbrah bovines subjected to a habituation process to human interaction and exposure training. Nineteen animals were used (8 females and 11 males). Reactivity was assessed through points in the restraint cage (1-5), a score for cage exit speed (1-2), and body weight in five assessments over 86 days. Linear mixed models and the effect of individual variations were adopted through a linear regression for each animal, using the b coefficients to classify the animals as habituated, neutral and sensitized. The sex of the animal did not affect the reactivity in the restraint cage, or the cage exit speed (p>0.05); however, reactivity decreased from day 16 (p<0.05) in relation to day 0 in both reactivity scores. There were individual differences in reactivity in the restraint cage and in body weight. On this, 74% of the animals became accustomed to the handling procedure, 21% showed neutral responses in the restraint challenge and 5% were sensitized. In turn, all animals gained weight at different levels, with positive, significant b coefficients (p<0.05) and R2 >0.70. In conclusion, the process of habituation to human interaction and exposure training consistently reduced the reactivity of the animals, without altering their productive performance; however, individual differences must be considered during handling procedures.
Evaluación agronómica de <i>Tithonia diversifolia</i> (Hemsl.) A. Gray basado en criterio de corte con tiempo térmico
Authors: Angulo-Arizala Joaquín , Mahecha-Ledesma Liliana , Barragán-Hernández Wilson , Casas-Toro Nancy 
Published: November 2024

Se evaluó el desempeño agronómico en producción y calidad de forraje de Tithonia diversifolia basado en criterio de corte con tiempo térmico. Se emplearon setos forrajeros de la arbustiva con parcelas de monitoreo y se asignaron tratamientos corte a 75 d calendario y corte con 300, 340 y 380 °C/d, bajo un diseño de bloques completos al azar. Los tratamientos de aprovechamiento con base en tiempo térmico registraron mayor (p<0.05) producción de masa forrajera al igual que mayor rendimiento en oferta de materia orgánica y fibra detergente neutra (p<0.05), especialmente en cosechas con 300 y 340 °C/d. Los resultados indican que el aprovechamiento climáticamente inteligente permite un mejor desarrollo de la planta y aprovechamiento óptimo del material forrajero con fines de alimentación animal.
Inequities in Inpatient Pediatric Patient Safety Events by Category
Authors: Pantell Matthew S. , Karvonen Kayla L. , Porter Paige , Stotts James , Neuhaus John , Bekmezian Arpi 
Published: November 2024

OBJECTIVES
Few studies have analyzed potential inequities in both pediatric patient safety events (PSEs) and adverse events (AEs) - PSEs leading to harm - nor in PSEs by event type. We sought to examine potential inequities in rates of pediatric PSEs overall, by severity, and by category based on race and ethnicity, insurance payor, and language as measured using voluntary incident reports (IRs).

METHODS
We conducted a retrospective cohort study of pediatric hospitalizations between January 19, 2012 through December 31, 2019 at a US urban, tertiary care children’s hospital. Analyzing 85 458 hospitalizations, we compared PSEs overall, by severity, and by event category by race and ethnicity, insurance payor, and language using incident rate ratios (IRRs).

RESULTS
In models controlling for covariates, we found that hospitalizations of Latinx (IRR 1.17, 95% confidence interval [CI] 1.07−1.29), non-Latinx Black/African American (IRR 1.17, 95% CI 1.01−1.34), publicly insured (IRR 1.10, 95% CI 1.02−1.20), and nonprivately/nonpublicly insured (IRR 1.12, 95% CI 1.02−1.23) children had higher rates of PSEs compared with reference groups, but the association between language and PSEs was not significant. There were similar patterns among AEs, although only the association between hospitalizations of Latinx patients and AEs was significant. Medication, fluid, or blood and lines or tubes PSEs drove many inequities.

CONCLUSIONS
We found inequities in PSEs as recorded by IRs, suggesting differences in care related to race, ethnicity, and payor. Limitations include analysis of a single center, that event categories are unique to the institution analyzed, and the voluntary nature of IRs.
Free Immunoglobulin Light Chains in Patients With Myocarditis: a New Biomarker of Inflammation and Heart Failure
Authors: Blagova O. V. , Lutokhina Yu. A. , Kozhevnikova M. V. , Zheleznykh E. A. , Fedorova A. Yu. , Kogan E. A. 
Published: November 2024

Aim. To study the concentration of immunoglobulin free light chains (FLCs) in patients with myocarditis in comparison with non-inflammatory heart diseases, their relationship with inflammatory markers and the severity of chronic heart failure (CHF).Material and methods. This study included 77 patients (31 women, mean age 54.1±13.3 years): 41 patients with myocarditis verified by myocardial biopsy (n=18) or using a noninvasive diagnostic algorithm, 31 patients with noninflammatory CHF (comparison group), and 5 patients with monoclonal gammopathy identified during the study (4 of them were diagnosed with AL amyloidosis with heart damage). In the myocarditis group, CHF was diagnosed in 29 patients, mean stage IIA, functional class (FC) 2-3, with a mean left ventricular ejection fraction 43%. In the comparison group, patients had predominantly IIA stage, FC 2-3 CHF without systolic dysfunction. The blood concentration of kappa and lambda FLC types was measured with Cloneus S-FLC-K TIA Kit and Cloneus S-FLC–L TIA Kit. Concentrations were considered normal at FLC-kappa 4.84-14.20 mg/l, FLC-lambda 7.03-22.50 mg/l, and the FLC-kappa/lambda ratio 0.426-1.050.Results. Increased FLC concentrations were found in 58% of patients with myocarditis and in 77% of patients in the comparison group. The FLC-lambda concentration was significantly higher in the comparison group; there were no significant differences between the groups in FLC-kappa and their ratio. The closest significant correlations in both groups and the entire cohort were noted between FLCs of either type and CHF, as well as the requirement for loop diuretics (correlation coefficients, 0.60-0.90), independent on the severity of systolic dysfunction. Myocarditis patients also showed correlations of FLCs with the titer of antibodies to cardiomyocyte nuclear antigens, levels of C-reactive protein, leukocytes, neutrophils, erythrocyte sedimentation rate, and the concentration of N-terminal fragment of brain natriuretic peptide. In a subgroup of 10 myocarditis patients who were treated with immunosuppressants, FLCs of both types were significantly lower than in the comparison group; only with the persistence of severe CHF was an increase in FLCs noted.Conclusion. An increased FLC concentration can be considered as an important pathogenesis component that reflects both the specific mechanisms of myocarditis and the severity of CHF. In the absence of a statistically significant increase in general inflammatory markers in the blood of myocarditis patients, the measurement of FLCs can be used as an additional diagnostic marker and predictor of the decompensated variant of the course of myocarditis. However, the diagnostic and prognostic significance of FLC concentration in patients without CHF requires a further study.
The Present Situation and Suggestion of Seed Quarantine Certificate Number
Authors: Feng Yuchen 
Published: November 2024

<p>Shanghai is an important port of seed trade in China. In recent years, invisible dangers and unexpected problems of seed production have occurred. Important quarantine pests such as cucumber green mottle virus disease, melon bacterial fruit mottle disease and rice bacterial stripe disease have been found successivel. These diseases seriously affected the safety of agricultural production and brand construction in Shanghai.<sup>[4]</sup> The number of seed quarantine certificate is an important measure to ensure the hygeian production of seeds from the beginning, which is of far-reaching significance to reduce the risk of pest infestation's introduction and protect the trade of agricultural products. As far as Shanghai's policy is concerned, there is still a long way to go before achieving a truly global level. Popularizing relevant laws and regulations of seed quarantine certification are the crucial factor to enhance the security in the trading and producing process. In this paper, several problems existing in the seed quarantine certificate are discussed. Also proposing some countermeasures and suggestions, which will provide a direction for the future development of seed quarantine certificate number.</p>
Propagation of Hydraulic Fractures and Natural Fractures: The Bypassing Behavior in 3D Space
Authors: Wang Yunpeng , Chen Ming , Guo Tiankui , Wang Zhen , Qu Zhanqing , Zhang Bo 
Published: November 2024

Summary
The interaction between natural fractures (NFs) and hydraulic fractures (HFs) in 3D space poses significant challenges to numerical simulation. The interaction behaviors between HFs and NFs in 3D space include crossing, offset, stopping, and bypassing. Many existing numerical simulators are 2D, which inherently limits their ability to account for the vertical growth of fractures. Consequently, they are unable to model the bypassing behavior effectively.
In this paper, a mathematical model for the propagation of HFs and NFs in a naturally fractured reservoir is established. The displacement discontinuity method (DDM) is used to solve the rock deformation, while the finite difference method (FDM) is utilized to solve the fluid flow within fractures. The undirected graph structure is used to represent the complex fracture network, and a dynamic adjustment of grid connectivity method is implemented to describe the process by which HFs bypass NFs. By integrating with graphics processing unit (GPU) computing, an efficient 3D simulator for HFs and NFs propagation is developed. The accuracy is verified against analytical solutions and reference solutions. Subsequently, a series of numerical studies on the bypassing behavior are conducted. The primary findings are as follows: (1) The simulator can accurately capture the interactions between HFs and NFs in 3D space, including crossing, arresting, and bypassing behaviors. (2) The bypassing behavior is characterized by three distinct processes—intersection, height growth of HF, and bypassing. (3) During the intersection stage, both the injection pressure and maximum NF width increase. During the height growth stage, the pressure is relatively stable, while the maximum NF width continues to increase. These two stages together result in the “storage” phenomenon. Once the bypassing behavior occurs, both the pressure and the maximum NF width decrease sharply, leading to a “release” phenomenon. Additionally, the “storage” and “release” phenomena may impact proppant transport. (4) Given the presence of bypassing behavior, it is essential to consider the NFs in 3D fracture simulators. The simulator and its findings can provide valuable insights for field design.
WITHDRAWN: Values of Lymphocyte-Related Ratios in Predicting the Clinical Outcome of Acute Ischemic Stroke Patients Receiving Intravenous Thrombolysis Based on Different Etiologies
Authors: Li Yongyu , Chen Keyang , Wang Lu , Zhao Linhu , Lei Chunyan , Gu Yu , Zhu Xiaoyan , Deng Qionghua 
Published: November 2024

Abstract

The full text of this preprint has been withdrawn by the authors due to author disagreement with the posting of the preprint. Therefore, the authors do not wish this work to be cited as a reference. Questions should be directed to the corresponding author.
An Automatic Recognition of Indian Dish and Allergen Prediction Using DeepLearning
Authors: Kadam Viren , Thengade Anita , Gunjal Anita , Aher Jayashree 
Published: November 2024

Abstract

The research addresses the issue of image variability in practical settings by introducing a deep learning-based system for allergy prediction and Indian dish recognition. Food plays a big part in supporting a healthy lifestyle, which is becoming more and more popular globally. Recognizing the different types of food and the allergies that are in it is crucial. With the help of convolutional neural networks and visual transformers, the model can predict possible allergies and identify foods with accuracy, which is important for managing diet and raising awareness of allergens. Its uses are extensive in the food service, medical, and nutrition domains, providing workable answers for safer and better-informed nutritional selections in Indian food. Extensive analysis validates the model's effectiveness and potential influence on many sectors. In this study, various CNN architectures, including ResNet50, VGG16, VGG19, and a custom CNN, were employed for Indian Dish Recognition and Allergy Prediction. To enhance model accuracy, techniques such as image augmentation were integrated. While certain models showed promising results, reaching a maximum accuracy of 81%, others did not meet the desired expectations. To improve performance, Vision Transformers (ViTs) were employed, resulting in a remarkable accuracy of 92%.
Utilizing Echocardiography for Cardiotoxicity Detection in Breast and Colorectal Cancer Patients Undergoing Chemotherapy
Authors: Rezwani Abdullatif , Shekarchizadeh Masood , Najafian Jamshid , Massoudi Soraya , Zavar Reihaneh , Sadeghi masoumeh , Darakhshandeh Ali , Vafaei Zamaneh , Akhavan Ali , Khosravifarsani Mohammadreza , Ashrafi Farzaneh , Mehrzad Valiollah , Sharifi Mehran , Emami Mohammad Hassan , Esfahani Mansoureh Shekarchizadeh , Sarrafzadegan Nizal 
Published: November 2024

Abstract

Background
Chemotherapy-induced cardiotoxicity poses a significant challenge in the management of breast and colorectal cancer patients, necessitating early detection strategies to reduce adverse cardiac outcomes.
Methods
This prospective multicenter cohort study was conducted between 2019 and 2024 to assess the efficacy of echocardiography for cardiotoxicity detection in patients undergoing chemotherapy for breast and colorectal cancer. Comprehensive echocardiographic evaluations were performed at base-line before initiation of chemotherapy and at six-month intervals, with additional assessments at one, two-, and three-year intervals post-treatment initiation.
Results
The study encompassed 203 patients, classified into two groups: those diagnosed with cancer therapy-related cardiac dysfunction (CTRCD) (n = 30) and those without CTRCD (n = 173). There were no significant differences between two groups in terms of demographic factors, comorbidities, lifestyle factors, and cancer type. Patients undergoing treatment for colon cancer experience significant changes in diastolic function, left ventricular volume indices, left atrial dimensions, and right ventricular function (P-value < 0.05). Similarly, patients with breast cancer undergoing treatment exhibit alterations in left ventricular function and volumes (P-value < 0.05). Furthermore, our study reveals that the use of Trastuzumab in breast cancer patients is significantly associated with a higher incidence of CTRCD; however, no significant association was found for other chemotherapy regimen including 5-FU, Capecitabine, Oxaliplatin, Irinotecan, Adriamycin, Epirubicin, Pertuzumab, and Cyclophosphamide.
Conclusion
The observed changes in LVEF and E/e' ratio suggest potential impacts of cancer treatment on cardiac function, emphasizing the necessity of cardiac monitoring in these patients.