bluuebunny/crossref_metadata_2025_split huggingface dataset:
Residual disability after severe relapse in people with multiple sclerosis treated with disease-modifying therapy
Authors: Achiron Anat , Sarova-Pinhas Ida , Magalashvili David , Stern Yael , Gal Aviva , Dolev Mark , Menascu Shay , Harari Gil , Gurevich Michael 
Published: November 2018

Background: The rate of post-relapse residual disability in patients with relapsing–remitting multiple sclerosis (RRMS) treated with disease-modifying drugs (DMD) has not been studied. Objective: To assess relapse residual disability in DMD-treated RRMS patients. Methods: We followed DMD-treated RRMS patients presenting with acute relapse who received high-dose steroids. Increases in Expanded Disability Status Scale (EDSS) of at least 2.0, 1.0–1.5 or 0.5 were defined as severe, moderate or mild relapses, respectively. The proportions of patients with post-relapse residual disability defined as the failure to regain pre-relapse neurological status at 1, 4 and 12 months were evaluated. Results: Out of 1672 relapses in DMD-treated RRMS patients, 17% were severe. In patients who presented with a severe relapse, we observed post-relapse residual disability of at least 1.0 EDSS point in 60.1%, 55.9% and 48.2% of patients at 1, 2 and 12 months of follow-up, respectively. Post-relapse residual disability of at least 2.0 EDSS points was observed in 37.4%, 30.7% and 20.7% of patients after 1, 2 and 12 months, respectively. Conclusion: A high rate of incomplete recovery was seen 12 months following severe relapse among RRMS patients and may contribute to the accumulation of long-term disability.
The role of integrin β1 in the heterogeneity of human embryonic stem cells culture
Authors: Kallas-Kivi Ade , Trei Annika , Stepanjuk Artjom , Ruisu Katrin , Kask Keiu , Pooga Margus , Maimets Toivo 
Published: November 2018

ABSTRACT
The maintenance of the pluripotency of human embryonic stem (hES) cells requires special conditions for culturing. These conditions include specific growth factors containing media and extracellular matrix (ECM) or an appropriate substrate for adhesion. Interactions between the cells and ECM are mediated by integrins, which interact with the components of ECM in active conformation. This study focused on the characterisation of the role of integrin β1 in the adhesion, migration and differentiation of hES cells. Blocking integrin β1 abolished the adhesion of hES cells, decreasing their survival and pluripotency. This effect was in part rescued by the inhibition of RhoA signalling with Y-27632. The presence of Y-27632 increased the migration of hES cells and supported their differentiation into embryoid bodies. The differences in integrin β1 recycling in the phosphorylation of the myosin light chain and in the localisation of TSC2 were observed between the hES cells growing as a single-cell culture and in a colony. The hES cells at the centre and borders of the colony were found to have differences in their morphology, migration and signalling network activity. We concluded that the availability of integrin β1 was essential for the contraction, migration and differentiation ability of hES cells.
Odbiorca ma znaczenie, czyli jak snuć opowieść o historii powojennej Czechosłowacji
Authors: Czaplińska Joanna 
Published: November 2018

Artykuł dotyczy roli odbiorcy w kreowaniu świata przedstawionego przez pisarzy w dwóch odmiennych sytuacjach: pisarza krajowego oraz emigracyjnego. Jako przykład posłużyły trzy powieści: krajowa Báječná léta pod psa (1992) Michala Viewegha oraz emigracyjne Ledová tříšť (Treibeis, 1992) i Zjasněná noc (Verklärte Nacht, 1997) Libušy Moníkovej. Podczas analizy zastosowano metodologię Pascale Cassanovy, dzielącą literatury na dwie grupy: literatury „słabe” i „mocne” lub, stosowane zamiennie, „młe” i „duże”. Okoliczności, w których tworzy autor, determinują środki wyrazu, jakich używa: pisarz krajowy jest w bardziej osobistym kontakcie z czytelnikiem, używa skrótów myślowych, ironii czy metafor, natomiast pisarz emigracyjny jest zmuszony do wyjaśniania szczegółów dotyczącyh ich ojczyzny, co skutkuje stosowaniem w tekście niemal eseistycznych pasaży. Rozważania te doprowadziły do konkluzji, że dla Moníkovej pisanie jest aktem patriotyzmu, poprzez który pragnie zapoznać swych niemieckojęzycznych czytelników z historią swojej ojczyzny, dla Viewegha zaś pisanie jest aktem ekspresji.
Is Education for Using Humour in Nursing Needed? (Slovenian Case Study on Sociological and Ergonomic Aspects of the Impact of Humour on Nursing Professionals)
Authors: Goriup Jana , Stričević Jadranka , Sruk Vida 
Published: November 2018

Abstract
Introduction: Although there has been considerable discussion regarding the presence of therapeutic aspects of humour in the nurse educational programme and syllabus, little is known about the use of humour in the nurse - patient relationship and the needed topics in the Slovene educational system for nurses. From educational and medical perspectives, humour is anything that evokes laughter and it has been proven that laughter contributes to physical health. A sense of humour in nursing has a conformist, quantitative and productive importance which is manifested through the essential elements of humour: meta-communication sensitivity, personal affection for humour and emotional admissibility. As nurses spend a lot of time with patients, humour adds to the quality of their work as well as to the nurses’ satisfaction with their work with patients. The aim of this paper is to contribute to a better understanding of the significance of humour in nursing both for the employees and for the patients and to discuss humour within the framework of nursing profession in Slovenia. The specific objective of our study is to explore the attitudes of Slovenian nurses towards humour and their actual use of humour during their interaction with patients. Methods: For the purpose of this study, a quantitative research methodology was adopted. A questionnaire was used to collect data on the topic and a set of statistical analyses (frequency distribution method, the χ2 and Spearman rank correlation test) was performed on the data obtained. Results: Our study shows that Slovenian nurses are prone to the use of humour in their work and they welcome it as an integral part of their work with patients. We found that humour also enhances their sense of belonging to the nursing profession and serves as a tool for socialization. Discussion: Humour, employed in nursing can help overcome certain difficulties which nurses face in the workplace as they also try to fulfil some social objectives and get socialized via humour. These psychological-sociological features of humour stand out as cognitive and social benefits of the positive emotions of joy, the use of humour for social communication and their influence on the release of stress and coping, which draws from the ergonomics of humour as social interaction. Therefore, topics of humour in nurse education are required. Limitations: 279 Slovenian nurses with different levels of education participated in the study. Conclusions: Humour should be used by nurses since it is important in their professional interaction with patients. It can be used as a bridge between individuals and can serve as a means of individual's integration into groups, cultures and, consequently, into the society as a whole.
Towards 2019 and the Future
Authors: Brett Christopher 
Published: November 2018

Abstract
When I am asked, in a conversation, what I do, I tell them I am a chemist and, if they studied sciences in their final years at school, I may tell them about my activities in IUPAC. The reaction to the first ranges from highly favourable to sceptical, and to the second saying that what they have heard most about IUPAC is the Periodic Table of the Chemical Elements and nomenclature. This is symptomatic of the challenges that we all, as scientists working in the field of chemistry, face in order to demonstrate and disseminate the importance of chemical and related sciences. It is what made most of us start connecting with IUPAC, often through the contact from a colleague or through an IUPAC-endorsed workshop or conference.
Chemistry of Small Spaces
Authors: Kitagawa Susumu 
Published: November 2018

Abstract
The fundamental science of materials and life, which has greatly contributed to humanity, lies in atoms and molecules. For two centuries, chemistry focused on synthesizing molecules or “skeletons assembled from atoms.” This approach led to the development of various substances (pharmaceuticals, foods, dyes, pesticides, clothes, plastics, etc.). In the late 20th century, this concept evolved into supramolecular chemistry, where molecules were used as constituents and eventually led to the nanoscience field.
Selenium– and tellurium–nitrogen reagents
Authors: Chivers Tristram , Laitinen Risto S. 
Published: November 2018

Abstract
The reactivity of the chalcogen–nitrogen bond toward main-group element or transition-metal halides, as well as electrophilic and nucleophilic reagents, is the source of a variety of applications of Se–N and Te–N compounds in both inorganic or organic chemistry. The thermal lability of Se–N compounds also engenders useful transformations including the formation of radicals via homolytic Se–N bond cleavage. These aspects of Se–N and Te–N chemistry will be illustrated with examples from the reactions of the binary selenium nitride Se4N4, selenium–nitrogen halides [N(SeCln)2]+ (n = 1, 2), the synthons E(NSO)2 (E = Se, Te), chalcogen–nitrogen–silicon reagents, chalcogen(IV) diimides RN=E=NR, the triimidotellurite dianion [Te(NtBu)3]2−, chalcogen(II) amides and diamides E(NR2)2 (E = Se, Te; R = alkyl, SiMe3), and heterocyclic systems.
Performance and Health-Related Characteristics of Physically Active Males Using Marijuana
Authors: Lisano Jonathon K. , Smith Jeremy D. , Mathias Alissa B. , Christensen Matthew , Smoak Peter , Phillips Kristina T. , Quinn Colin J. , Stewart Laura K. 
Published: November 2018

Abstract
Lisano, JK, Smith, JD, Mathias, AB, Christensen, M, Smoak, P, Phillips, KT, Quinn, CJ, and Stewart, LK. Performance and health-related characteristics of physically active men using marijuana. J Strength Cond Res 33(6): 1659–1669, 2019—The influence of chronic marijuana use on the performance and health of physically active individuals has yet to be fully elucidated. The purpose of this study was to explore pulmonary function, aerobic and anaerobic fitness, strength, serum testosterone, cortisol, C-reactive protein (CRP), Δ-9-tetrahydrocannabinol (THC), 11-nor-9-carboxy-Δ-9-tetrahydrocannabinol (THC-COOH), and 11-hydroxy-Δ-9-tetrahydrocannabinol (THC-OH) concentrations in a physically active population either using or not using marijuana. Healthy, physically active males (N = 24) were compared based on their marijuana-use status: marijuana users (MU; n = 12) and nonusers (NU; n = 12). Statistical analysis (p = 0.05) revealed no difference between groups for age, body mass, body mass index, body fat, forced expiratory volume in 1 second percentage, Vo
2max, anaerobic power output, strength measures, testosterone, or cortisol concentrations. Although not statistically significant, MU showed a trend to fatigue to a greater percentage of absolute power output than NU from the beginning to the end of the Wingate Anaerobic Power Assessment (p = 0.08, effect size = 0.75). C-reactive protein in MU (1.76 ± 2.81 mg·L−1) and NU (0.86 ± 1.49 mg·L−1) was not significantly different (p = 0.60) but placed MU at moderate risk and NU at low risk for cardiovascular disease. Anaerobic fatigue was the only performance variable to show a trend for difference between groups. These results suggest that marijuana use in physically active males may not have significant effects on performance; however, it may be linked to elevated concentrations of CRP which place users at a higher risk for cardiovascular disease.
Verification of an Internal Close-Range Photogrammetry Approach for Volume Determination during Triaxial Testing
Authors: Salazar Sean E. , Miramontes Leah D. , Barnes Adam , Bernhardt-Barry Michelle L. , Coffman Richard A. 
Published: November 2018

AbstractAccurate strain and volume measurements are critical to phase relationships and strength determination for saturated and unsaturated soils. In recent years, laboratory-based photographic techniques of monitoring soil specimens have become more common. These techniques have been used to reconstruct 3-D models and to determine strain and volumetric changes of triaxial specimens. A new technique that used digital photographs of the soil specimen, captured from within a triaxial testing cell, was utilized. Photographs were processed using photogrammetric software to reconstruct 3-D models of the soil specimens at various times during the triaxial test. By placing camera equipment within the cell, the technique eliminated the need to account for optical distortions that were due to (1) refraction at the confining fluid–cell wall–atmosphere interface, (2) the curvature of the cylindrical cell wall, and (3) the pressure-induced deformation of the cell wall. Previously unreported results from sensitivity studies and accuracy assessments for the internal photogrammetry approach are documented herein. Furthermore, through undrained triaxial compression and extension tests, the viability of determining total and local strains, volume changes, and total volume at any stage of triaxial testing was demonstrated. By comparison with other volume-determination methods that are presented herein, including digital single-lens reflex camera photogrammetry, 3-D scanning, manual measurements, and water displacement techniques, a relative error of 0.13 % was assessed for the internal photogrammetric volume determination technique.
iProteinDB: An Integrative Database of Drosophila Post-translational Modifications
Authors: Hu Yanhui , Sopko Richelle , Chung Verena , Foos Marianna , Studer Romain A , Landry Sean D , Liu Daniel , Rabinow Leonard , Gnad Florian , Beltrao Pedro , Perrimon Norbert 
Published: November 2018

Abstract
Post-translational modification (PTM) serves as a regulatory mechanism for protein function, influencing their stability, interactions, activity and localization, and is critical in many signaling pathways. The best characterized PTM is phosphorylation, whereby a phosphate is added to an acceptor residue, most commonly serine, threonine and tyrosine in metazoans. As proteins are often phosphorylated at multiple sites, identifying those sites that are important for function is a challenging problem. Considering that any given phosphorylation site might be non-functional, prioritizing evolutionarily conserved phosphosites provides a general strategy to identify the putative functional sites. To facilitate the identification of conserved phosphosites, we generated a large-scale phosphoproteomics dataset from Drosophila embryos collected from six closely-related species. We built iProteinDB (https://www.flyrnai.org/tools/iproteindb/), a resource integrating these data with other high-throughput PTM datasets, including vertebrates, and manually curated information for Drosophila. At iProteinDB, scientists can view the PTM landscape for any Drosophila protein and identify predicted functional phosphosites based on a comparative analysis of data from closely-related Drosophila species. Further, iProteinDB enables comparison of PTM data from Drosophila to that of orthologous proteins from other model organisms, including human, mouse, rat, Xenopus tropicalis, Danio rerio, and Caenorhabditis elegans.
Diagnostic value of biochemical markers of bone metabolism in treatment of generalized periodontitis in patients with age-related osteoporosis
Authors: Fastovets O. O. , Masheiko I. V. , Peleshenko H. B. 
Published: November 2018

The topicality of the problem of periodontal diseases is due to their significant prevalence. The purpose of this work is to study the dynamics of markers of bone metabolism in the process of treatment of generalized periodontitis of the II–III levels of severity in patients with age-related osteoporosis and without osteoporotic changes in the skeleton. The examination and treatment of 104 patients, aged 63–78, equal ratio of men and women, was conducted. Among the selected patients, 49 persons had normal bone mineral density, while the remaining 55 had osteoporotic changes in the bone tissue of involutory genesis. All subjects were assessed for the following indicators ; mineral density of jaw bone tissue (BMD) according to the results of the computer tomography, the concentration of C-Propeptide of Type I Procollagen (CICP) in blood plasma, the activity of tartrate-resistant acid phosphatase (TRAP), bone alkaline phosphatase (BAP), osteocalcin, parathyroid hormone in blood serum, concentration of β-CrossLaps in urine, total calcium and inorganic phosphorus content in blood with calculation of the Ca/P index. It was established that in patients with periodontitis of the II–III degree there was a decrease in the BMD of the alveolar bone in comparison with the control values (P ˂ 0.05), whereas the presence of systemic osteopenia worsened the indices (P ˂ 0.001). The least osteoregenerative activity, which was characterized by the decrease in BAP, TRAP and CICP levels, was registered in patients with generalized periodontitis of the III degree on the background of age-related osteoporosis (P ˂ 0.05). In the patients with generalized periodontitis of the III degree of severity, at the beginning of treatment, a weak negative correlation was found between BMD and TRAP activity (r = –0.292, P < 0.05) and mean strength correlation – with β-CrossLaps in urine (r = –0.348, P < 0.01). The concentration of CICP positively correlated with the mineral density of bone tissue from the third month after the start of treatment (r = 0.312, P < 0.05). As a conclusion, the mineral density of alveolar bone in the process of treatment varies unevenly depending on the severity of generalized periodontitis and the character of osteoporotic changes in the skeleton. The biochemical markers of bone metabolism allow the balance of processes of bone resorption and formation to be determined in order to correct treatment of generalized periodontitis.
PERAN SEKTOR PERIKANAN PADA WILAYAH PESISIR PERBATASAN KALIMANTAN BARAT
Authors: Firdaus Maulana , Rahadian Rikrik 
Published: November 2018

ABSTRAKPembangunan wilayah pesisir perbatasan menjadi sebuah tantangan besar karena selalu identik dengan ketertinggalan. Sektor perikanan dianggap telah teruji dan mampu menjadi mesin pertumbuhan ekonomi. Penelitian ini bertujuan untuk mengetahui peranan sektor perikanan di wilayah perbatasan (Kalimantan Barat) Indonesia khususnya yang ada di Kabupaten Sambas. Pendekatan kebutuhan minimum dan analisis ”location quotient” digunakan dalam penelitian ini. Hasil analisis menunjukkan bahwa sektor perikanan di wilayah perbatasan Kalimantan Barat memiliki peranan yang besar. Besarnya peranan sektor perikanan ditunjukkan dengan nilai basis multiplier dari sektor perikanan sebesar1,09 dan nilai LQ sebesar 3,18. Pengembangan sektor perikanan di wilayah perbatasan memerlukan dukungan arah kebijakan dan infrastruktur sehingga sektor perikanan dapat menjadi sektor unggulandan penggerak pertumbuhan.The Role of Fisheres Sector in the Coastal Border Areas of West BorneoABSTRACTDevelopment of coastal border areas becomes a great challenge since it is identically the same with backwardness. Fisheries sector is considered capable to be the engine of economic growth. This study aims to identify the role of the fisheries sector in the border areas (West Borneo) of Indonesia particularly in Sambas district. The Minimum Requirement Approach (MRA) and Location Quotient (LQ) were used in this study. The analysis shows that fisheries sector in West Borneo border areas has asignificant role. It is indicated by the value of multiplier basis of the fishery sector in Sambas district of 1.09 and LQ of 3,18. Government policies and infrastructures are required to develop fisheries sector in the border areas in order to create a leading sector and economic trigger.
SIMULAÇÃO PARA DETERMINAÇÃO DAS ÉPOCAS DE SEMEADURA COM MENOR RISCO DE ESTRESSE HÍDRICO PARA O FEIJÃO NA REGIÃO CENTRAL DO RIO GRANDE DO SUL
Authors: Silva Joel Cordeiro da , Heldwein Arno Bernardo , Martins Fabrina Bolzan , Maass Guilherme Fabiano 
Published: November 2018

SIMULAÇÃO PARA DETERMINAÇÃO DAS ÉPOCAS DE SEMEADURA COM MENOR RISCO DE ESTRESSE HÍDRICO PARA O FEIJÃO NA REGIÃO CENTRAL DO RIO GRANDE DO SUL Joel Cordeiro da Silva, Arno Bernardo Heldwein, Fabrina Bolzan Martins, Guilherme Fabiano MaassDepartamento de Fitotecnia, Universidade Federal de Santa Maria, Centro de Ciências Rurais, Santa Maria, RS, joelcordeiro@mail.ufsm.br 1 RESUMO O objetivo deste trabalho foi determinar as épocas de semeadura com menor risco de ocorrência de estresse hídrico para a produção de feijão na região Central do Rio Grande do Sul. As deficiências e os excessos de água no solo foram determinados pelo cálculo do balanço hídrico diário do solo, simulando-se o desenvolvimento do feijoeiro em 29 épocas de semeadura, para cada ano dos dados coletados na Estação Climatológica principal de Santa Maria (lat: 29°43’23’’S, long: 53°43’15’’W e alt: 95m), desde agosto de 1968 até julho de 2004. Considerando-se que há maior risco de redução de rendimento, quando ocorre deficiência hídrica nos primeiros 20 dias da floração e quando ocorre excesso hídrico entre a semeadura e a emergência e entre 20 dias após o início da floração e a maturação fisiológica, constatou-se que as melhores épocas para a semeadura do feijoeiro na região central do Rio Grande do Sul são os períodos de 20/set e 01/out e entre 05 e 15 de fevereiro. UNITERMOS: balanço hídrico, Phaseolus vulgaris, função de distribuição de probabilidade, risco climático. SILVA , J. C. da; HELDWEIN, A. B.; MARTINS, F. B.; MAASS, G. F.SIMULATION TO DETERMINE SOWING SEASONS WITH SMALLEST RISK OF WATER STRESS FOR BEAN CROP IN THE CENTRAL REGION OFRIO GRANDEDOSUL STATE,BRAZIL 2 ABSTRACT The objective of this study was determine the sowing seasons with smallest risk of water stress for the bean production in the Central area of Rio Grande do Sul (RS) state, Brazil. The water balance of the soil was calculated to determine the deficiencies and surpluses of soil water for 29 growing seasons. Data were collected in a climatological station inSanta Maria, RS (lat: 29°43’23’’S, long: 53°43’15’’W and alt: 95m) from August of 1968 to July of 2004. Considering that the greatest risk of damage is when water deficiency takes place during the periods from sowing to germination and from the beginning of flowering to 20 days after and when water surplus takes place during the first 20 days of flowering, the results allowed to conclude that the recommended growing seasons are 20/Set to 01/Out and 05/Fev to 15/Fev. KEYWORDS: water balance, Phaseolus vulgaris, probability distribution function, climatic risk.