bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Effect of Viola Odorata L. Oil for Fever in Children: A Randomized Triple-blinded Placebo-controlled Clinical Trial
Authors: Tafazoli Vahid , Shahriari Mahdi , Heydari Mojtaba , Nikbakht Hosein Ali , Zarshenaas Mohammad M. , Nimrouzi Majid 
Published: July 2019

Introduction:
Finding non-systemic antipyretic option in cancer patients who simultaneously
receive several other drugs seems be logical. This study was designed to evaluate complementary therapy
with Viola odorata L. oil for fever control in febrile neutropenic children.

Methods and Materials:
In a randomized placebo controlled clinical trial, 41 febrile children were divided
into two groups. Children in the active drug group received viola oil (20 drops) to be rubbed on the
peripheral margin of the patient umbilicus. Primary outcome measure of the study was the mean axillary
temperature in the 30, 60, and 240 minutes after the intervention.

Results:
The mean temperature reduced significantly in the viola group after 30 minutes of administration
(p =0.005), while there was no significant change in the placebo group (p =1.00). The number of patients
who received paracetamol as the rescue treatment was significantly lower in the viola group than
that in the placebo group (5 vs. 17, p =0.001).

Conclusion:
The results of our study showed the safety and efficacy of complementary therapy with Viola
odorata L. oil for fever control in febrile neutropenic children during hospital course.
Airway Obstruction in a Cancer Patient: Is it Always Cancer?
Authors: Hinds Nicholas , Borah Amit , Morrow Kathy , Hoag Jeffrey , Abramian Emil 
Published: July 2019

:
Allergic Bronchopulmonary Aspergillosis (ABPA) is a common hypersensitivity to Aspergillus sp. that is well described in the literature. The populations most susceptible to developing this reaction are asthmatics and patients with cystic fibrosis (CF). The presenting symptoms can vary as ABPA is rarely described in otherwise normal individuals, however, in patients with an underlying familial predisposition to atopy, it can be seen. This case illustrates the importance of how ABPA can affect a patient who does not fit into a typical phenotypic profile.
A Prospective Study of the Clinical and Demographic Profile of Type 2 Diabetes Mellitus Patients Receiving Antidiabetic Drug Combinations
Authors: Gadgade Akash , Kudgi Ashok S. , Kamath Ashwin , Kamath Priyanka , Adhikari Prabha , Revappala Nishith S. , Hadigal Sanjay , Natarajan Srikant , Shenoy Nandita , Chowta Mukta N. 
Published: July 2019

Background:
The specific treatment recommendations for type 2 diabetes mellitus (T2DM)
differ based on a particular guideline. The goal of pharmacotherapy is to achieve the target HbA1c and
fasting and postprandial blood glucose levels to avoid disease complications.

Objective:
To evaluate the profile of T2DM patients on different antidiabetic treatment regimens and
the factors leading to dose escalation in these patients.

Methods:
A prospective descriptive study was conducted at Kasturba Medical College Hospital, Mangalore,
a tertiary care teaching hospital, over a period of one year. The study population comprised of
patients with T2DM for ≥5 years. The demographic and clinical data were collected during the baseline
and follow-up visits.

Results:
Of the 119 patients studied, 59.7% were males; 32.8% were ≥65 years of age. A significant
decrease in the fasting blood glucose (FBG) on follow-up was seen (p = 0.028) in patients on sulfonylurea
and metformin combination. A significant decrease in the glycated haemoglobin (HbA1c) was
seen in patients on sulfonylurea with metformin and pioglitazone (p = 0.011); sulfonylurea with metformin,
pioglitazone, and sitagliptin (p = 0.026); and metformin with insulin (p = 0.001). Patients who
received dose escalation had a longer duration of the disease (p = 0.042), higher FBG (p = 0.039) and
HbA1c (p = 0.05).

Conclusion:
A combination of metformin with sulfonylurea was the preferred first-line treatment; insulin
was added when HbA1c was >9. Patients who received dose escalation had a longer duration of
the disease and higher FBG and HbA1c.
Coenzyme Q10 Attenuates Cisplatin-induced Nephrotoxicity Through Counteracting Oxidative Stress and Inflammation
Authors: Bash Hala S. , Rabeea Ihsan S. 
Published: July 2019

Background:
Cisplatin is an anticancer drug used in the management of solid tumors,
however, dose-related nephrotoxicity is one of its major problems. Agents having antioxidants, antiinflammatory
and/or antiapoptotic activities may thus represent potential therapeutic options to avoid
cisplatin-induced nephrotoxicity. Among these agents, coenzyme Q10 has several pharmacological
properties including antioxidant, anti-inflammatory and/or anti-apoptotic effects.

Objective:
The current study aimed to examine whether coenzyme Q10 could attenuate cisplatininduced
nephrotoxicity or not.

Methods:
24 adult rats were randomly separated into three groups (8 rats per group). The first one
was the control group, rats receiving vehicle (olive oil) intraperitoneally. The second group was Cisplatin
treated group, rats were receiving 13 mg/kg of Cisplatin intraperitoneally as a single dose. The
third group (Cisplatin + Coenzyme Q10), rats were receiving 13 mg/kg as a single intraperitoneal dose
of Cisplatin and coenzyme Q10 daily for six consecutive days (10 mg/kg intraperitoneally).

Results:
Cisplatin caused significant increases in serum creatinine and severe histological lesions.
Cisplatin treated group also showed a significant elevation in renal malondialdehyde concentration as
a marker of oxidative stress; renal tumor necrosis factor-alpha concentration as a marker of inflammation;
and Kidney injury molecule -1 concentration. Coenzyme Q10 significantly attenuated cisplatininduced
nephrotoxicity through lowering serum creatinine and improving nephrotoxicity histological
scores. Coenzyme Q10 also significantly reduced the renal concentration of MDA, TNF-α and KIM-1
relative to cisplatin treated group.

Conclusions:
Coenzyme Q10 has a potential nephroprotective effect against cisplatin-induced nephrotoxicity
that was demonstrated by biochemical and histopathological analysis.
Development and Characterization of Glipizide Loaded Sustained Release Nanoparticles
Authors: Deshmukh Rutuja , Waghulde Mrunal , Mishra Satyendra , Naik Jitendra 
Published: July 2019

Background:Treating the disease like diabetes is essential due to its wide range of spreading and heredity issues. Glipizide is the commonly used drug for the treatment of diabetes. Glipizide loaded sustained release nanoparticles have been developed to avoid repeated dosing.Objective:The study aimed to develop glipizide-loaded sustained release nanoparticles and characterize them for different studies.Methods:The aim of the present study was to develop glipizide-loaded sustained release nanoparticles using different polymers by the solvent evaporation method. The polymers; Eudragit (RS 100) in combination with Polycaprolactone (PCL) were used to encapsulate glipizide. Optimization of all parameters was performed as per Design Expert software by utilizing a 32 full factorial design. The developed nanoparticles were characterized using Fourier transformed infrared spectroscopy, X-ray diffraction, scanning electron microscopy and in-vitro drug release study.Results:FE-SEM showed that the surface morphology of nanoparticles was smooth and spherical as well as in an oval shape. FTIR shows there is no interaction between polymers and drug. XRD results showed that the crystallinity of pure glipizide reduced from 89.5 to 56.7% when converted into sustained release nanoparticles formulation. Sustained drug release over the period of 12 h was observed due to well encapsulation of glipizide by the polymers.Conclusion:Glipizide loaded nanoparticles were developed with good encapsulation efficiency using a combination of two different biocompatible polymers. The drug release behavior showed that they can be used to develop the sustained release formulation to reduce the side effect caused by over drug uptake as compared to the conventional formulation.
Effeciency of Initial-I Stage Generalized Periodontitis Treatment Among Medical University Students According to Indicators of Oral Cavity Prooxidant-antioxidant System
Authors: Pavliuk Tetiana , Rozhko Mykola 
Published: July 2019

Periodontal diseases are one of the most important problems in dentistry, due to its very high dissemination. Inflammatory processes in periodontal tissues are more common among young people, which, in the future, without adequate treatment lead to irreversible changes in structure of cellular bone. This causes development of new effective therapeutic complexes aimed at eliminating etiopathogenetic factors development of periodontal tissues inflammatory diseases and the targeted influence on the pathological processes in these tissues.
The objective of the study was to analyze the efficiency of suggested initial-I stage generalized periodontitis treatment among second-year students of medical university.
Materials and methods. To achieve this goal, we examined and treated 50 students with initial-I stage of generalized periodontitis without somatic pathology, which were divided into two groups, depending on treatment method. First group included 25 students who received advanced treatment; second group included 25 students, who received usual treatment. Control group consisted of 20 clinically healthy students. The state of oral cavity prooxidant-antioxidant system was determined by the level of malone dialdehyde (MDA), diene conjugates (DK), superoxide dismutase (SOD) activity, glutathione-S-transferase (G-ST), and the activity of glutathione peroxidase (GPO).
Results and discussion. Periodontal diseases, namely, initial-I stage of GP, are accompanied by an imbalance of oral cavity prooxidant-antioxidant system indicators. This is confirmed by an increase number of MDA and DK (p<0.001), and a decrease in SOD, G-ST, GPO (p<0.001) compared to clinically healthy students.
Conclusions. The results of GP treatment in first group were significantly better in relation to the second one (p<0.05), indicating the effectiveness of the proposed advanced treatment of initial-I stage of GP.
Dynamics of Indicators of Structural and Functional State of the Heart in the Post-Infarction Period Depending on the Presence of Decompensated Heart Failure
Authors: Levandovska Khrystyna 
Published: July 2019

Echocardiographic indicators in decompensated heart failure demonstrate a high prevalence of structural and hemodynamic abnormalities. In the patients with decompensated heart failure in the early and late post-infarction period, echocardiographic indicators were found to significantly differ from those recorded in the patients without heart failure. Thus, reduced ejection fraction, increased end-diastolic volume and end-diastolic dimension indicate left ventricular systolic dysfunction and left ventricular cavity dilation. Since echocardiography of the heart and the pulmonary artery enables real-time estimation of cardiac filling, signs of systolic dysfunction and pulmonary congestion, it may serve as a predictor of decompensated heart failure development in the early and late post-infarction period.
The objective of the research was to determine the main echocardiographic indicators in terms of rapid monitoring of deterioration in the main parameters of left ventricular overload for early diagnosis of decompensated heart failure, as well as structural and geometric remodeling of left ventricular myocardium in the early and late post-infarction period.
Materials and methods. There were examined 160 patients with acute myocardial infarction. Depending on the development of decompensated heart failure in the early and late post-infarction period, the patients were divided into two subgroups being homogeneous by age and gender.
Results. The results obtained indicated significant hemodynamic changes in the patients with decompensated heart failure in the post-infarction period. They included significantly lower values of ejection fraction indicating left ventricular systolic dysfunction and the signs of left ventricular cavity dilation as evidenced by the increase in left ventricular end-diastolic volume and end-diastolic dimension. The tendency for an increase in left ventricular posterior wall thickness and interventricular septal thickness, as well as left ventricular myocardial mass, left ventricular myocardial mass index and left ventricular radius to wall thickness ratio indicated concentric left ventricular remodeling.
Conclusions. Modern management of patients with decompensated heart failure should be guided by an objective value of left ventricular ejection fraction as it plays a key role in selecting management strategy for this cohort of patients since a significant reduction in this parameter indicates cardiac decompensation. Pulmonary artery pressure and concentric left ventricular hypertrophy play a significant role in cardiac failure development as well.
Kemitraan lembaga swadaya masyarakat dalam rangka pemberdayaan ekonomi pada program sekolah lapangan kakao
Authors: Novianti Novianti , Suryono Yoyon , Fauziah Puji Yanti 
Published: July 2019

Penelitian bertujuan untuk mendeskripsikan implementasi program, bentuk kemitraan yang dilakukan LSM, pemberdayaan ekonomi yang terjadi, dan bentuk-bentuk pengembangan dalam rangka keberlanjutan pada program Sekolah Lapangan Kakao yang terjadi di kampung Kalifam. Penelitian menggunakan metode studi kasus, dengan pengumpulan data menggunakan wawancara kepada informan bersifat purposive sampling yakni peserta program yang adalah tokoh adat dan tokoh masyarakat, perwakilan LSM, dan mitra yang terlibat dalam program. Hasil penelitian menunjukkan bahwa implementasi program, mulai dari tujuan, proses dan hasil kegiatan dinilai baik; proses kemitraan juga yang dilakukan mendapat penilaian yang baik dari pihak-pihak yang terlibat yaitu LSM sebagai inisiator program, unsur-unsur masyarakat sebagai peserta program, gereja selaku motivator masyarakat dan Petugas Penyuluh Lapangan (PPL) selaku fasilitator; pemberdayaan ekonomi masyarakat belum sepenuhnya terjadi walaupun masyarakat telah berdaya di level pengetahuan dan keterampilan budidaya kakao; pengembangan program yang diharapkan mulai dari komitmen peserta terhadap keterampilan, proses pendampingan, kebun percontohan, dan pelatihan teknologi pengolahan hasil. Nongovernment organization’s partnership as part of economic empowerment on cacao’s farmer’s field school AbstractThe study aims to describe the implementation of the program, forms of partnership done by NGO, the economic empowerment, and other forms of development in the context of sustainability at Cocoa’s Farmer’s Field School program that took place in the Kalifam village. This qualitative research used the case study method; with data collection used the interview to the informant with the purposive sampling characteristic which are program’s participants: traditional and community leader, NGO’s representatives, and partners involved in the program. The results showed that the implementation of the program, ranging from the purpose, process and results of activities considered good; the partnership also conducted gets a good assessment of the parties involved, which are the NGO as the initiator of the program, the elements of society as a participant of the program, the church as a community motivator and PPL as a facilitator; economic empowerment has not fully occurred even though the community empowerment has been revealed in the level of knowledge and skills of cocoa cultivation; the program developments expected are start from the participants' commitment to the skills, process assistance, cacao’s model plantation, and the training of technology processing.
Efikasi diri mahasiswa pada perkuliahan kalkulus integral
Authors: Purnomo Mega Eriska Rosaria , Sari Christina Kartika , Rejeki Sri , Machromah Isnaeni Umi 
Published: July 2019

Penelitian kualitatif ini bertujuan untuk mendeskripsikan pofil efikasi diri mahasiswa pada perkuliahan Kalkulus Integral. Subjek penelitian adalah 43 mahasiswa Program Studi Teknik Industri Universitas Muhammadiyah Surakarta yang mengikuti perkuliahan Kalkulus Integral. Instrumen pengumpulan data terdiri dari angket efikasi diri serta pedoman wawancara. Subjek mengisi angket efikasi diri. Hasilnya adalah 2% mahasiswa memiliki efikasi diri sangat tinggi, 40% tinggi, 51% sedang, 7% memiliki efikasi diri rendah. Selanjutnya dipilih 6 mahasiswa, masing-masing 2 mahasiswa dengan efikasi diri tinggi, sedang, rendah untuk diwawancarai. Hasilnya yaitu mahasiswa dengan efikasi diri tinggi dan sedang tidak putus asa dalam menyelesaikan permasalahan Kalkulus Integral, sedangkan mahasiswa dengan efikasi diri rendah putus asa saat menghadapi permasalahan tersebut. Mahasiswa dengan tingkat efikasi diri tinggi, sedang, dan rendah belum mampu mempelajari materi sulit Kalkulus Integral secara mandiri. Akan tetapi, mereka mampu menyelesaikan tugas dan mengumpulkannya tepat waktu. Usaha belajar mereka belum optimal dengan berbagai macam penyebab sehingga mereka tidak yakin mampu mencapai prestasi belajar yang ditargetkan, terkecuali dua mahasiswa dengan efikasi diri tinggi dan sedang. Self-efficacy of university student in integral calculus course AbstractThis qualitative research aimed to describe students’ self-efficacy profile on Integral Calculus course. The subjects were 43 students of Industrial Engineering Department, Universitas Muhammadiyah Surakarta, who attended Integral Calculus course. The instruments used to data collecting were self-efficacy questionnaire and interview guidelines. The subjects were given self-efficacy questionnaire. The results showed that 2% of students had very high of self-efficacy, 40% high, 51% middle, the remaining 7% students had low self-efficacy. Six students were selected to be interviewed, consisted of 2 students with high, middle, and low self-efficacy. The interview results were students with high and middle self-efficacy were not give up to solve Integral Calculus problems, while students with low self-efficacy tend to desperate when solving the problems. Students with high, middle, and low self-efficacy levels had not been able to study the Integral Calculus difficult material independently. However, they were able to complete the task and collect it on time. Their learning efforts have not been optimal with a variety of causes so they were not confident for reaching optimum achievement, except two students with high and middle self efficacy level.
Pembelajaran bahasa Inggris for specific purposes
Authors: De Araujo Aniceto Jordao 
Published: July 2019

Penelitian ini bertujuan untuk mengungkapkan profil STM Negeri Dili Timor Leste, guru bahasa Inggris, dan pihak-pihak yang terkait dengan pembelajaran bahasa Inggris; dan proses pembelajaran bahasa Inggris for specific purposes. Metode penelitian ini adalah deskriptif kualitatif. Subjek penelitian ini adalah guru-guru bahasa Inggris, siswa/i kelas XI dan XII STM Negeri Dili serta dua orang penanggungjawab kurikulum dari Kementerian Pendidikan Timor Leste. Pengumpulan data melalui wawancara, observasi, dokumentasi, dan angket. Analisis data dengan klasifikasi data, transkripsi, verifikasi, dan kesimpulan. Hasil penelitian menunjukkan bahwa pembelajaran bahasa Inggrisfor specific purposes tidak didukung oleh (1) kemampuan sumber daya manusia dan kreativitas guru; (2) perangkat pembelajaran; (3) pelatihan bagi guru bahasa Inggris yang relevan; (4) peningkatan kesejahteraan dan kinerja; (5) budaya dan lingkungan dalam proses pembelajaran siswa. The learning of English for specific purposes AbstractThis study aims to reveal the profiles of STM Negeri Dili, Timor Leste, English teachers, and parties related to the English learning; and the English learning process for Specific Purposes. The study employed the qualitative descriptive method. The research subjects were English teachers, male and female students of Grades XI and XII of STM Negeri Dili, Timor Leste, and two people in charge of curriculum the Ministry of Education of Timor Leste. The data were collected by interview, observation, documentation, and a questionnaire. The data analysis through data classification, transcription, verification and conclusion drawing. The results of the study show that the learning of English for Specific Purposes is not supported by (1) the human resources’ competencies, teachers’ creativity; (2) learning kits; (3), the training for English teachers is relevant; (4) improvement of welfare and performance; (5) culture and environment in students’ learning.
Kalimat koordinatif dalam bahasa melayu serdang: Analisis x-bar
Authors: Ginanti Indira , Mulyadi Mulyadi 
Published: July 2019

Penelitian ini dilakukan untuk mendapatkan hasil dan data untuk mencari dan membedah kalimat koordinatif dalam bahasa Melayu Serdang (BMS) yang menggunakan teori X-bar. Penelitian ini juga bertujuan untuk membuktikan bahwa struktur dalam BMS dan bahasa Indonesia itu tidak berbeda. Baik berdasarkan pola kalimat maupun kontruksinya. Penelitian ini menggunakan metode padan yang memadankan antara bahasa Indonesia dan BMS. Jadi, dalam membedah struktur batin yang terdapat dalam BMS yang menggunakan teori X-bar itu disepadankan dengan bahasa Indonesia. Adapun objek kajian yang ditelaah adalah kalimat koordinatif. Kalimat koordinatif ini tentu memiliki konjungsi koordinatif di dalamnya. Konjungsi koordinatif itu ada bermacam-macam. Ada yang menggunakan kata “bahwa”, “sekiranya”, “tetapi, “dan”, dan konjungsi koordinatif lainnya. Konjungsi koordinatif dalam bahasa Indonesia tersebut disepadankan dengan konjungsi koordinatif dalam BMS. Adapun alat pembedah kalimat-kalimat tersebut dalam BMS adalah teori X-bar. Teori X-bar ini pertama kali ditemukan oleh Chomsky. Dalam teori X-bar, kategori leksikal sebuah kata itu menjadi inti dari frasa, klausa, ataupun kalimat. Kategori leksikal verba itu adalah inti dari frasa verba, nomina adalah inti dari frasa nomina, adjektiva adalah inti dari frasa adjektiva, infleksi adalah inti dari frasa infleksional. AbstractThis research was conducted to get the results and data to find and dissect the coordinative sentence in Serdang Malay Language (SML) by using the X-bar theory. This research also aims to prove that the structure in SML and Indonesian have no different. Both based on sentence patterns and their construction. This research uses a matching method that combines Indonesian language and SML. So, to prove the inner structure contained in SML that uses the X-bar theory, it is compared to Indonesian. The object of the research that was examined by the coordinative sentence. This coordinative sentence certainly has coordinative conjunctions in it. There are various coordinative conjunctions. Some use the words "that", "if", "but", "and", and other coordinative conjunctions. Coordinative conjunction in Indonesian is compared to coordinative conjunction in SML. The dissecting tool for these sentences in SML is the X-bar theory. This X-bar theory was first done by Chomsky. In X-bar theory, the lexical category of a word becomes the core of phrases, clauses, or sentences. The lexical category of verbs is the core of verb phrases, nouns are the core of noun phrases, the adjective is the core of the adjective phrase, inflection is the core of the inflectional phrase.