bluuebunny/crossref_metadata_2025_split huggingface dataset:
Statistical characterization of an urban dual‐polarized MIMO LMS channel
Authors: Nikolaidis Viktor , Moraitis Nektarios , Kanatas Athanasios G. 
Published: June 2018

SummaryThis paper presents a thorough statistical characterization of a dual‐polarized multiple‐input‐multiple‐output channel, based on a measurement campaign of 2 land mobile satellite link scenarios in urban environments. The received signal is decomposed into its large‐scale and small‐scale fading parts, which are separately evaluated and characterized. The large‐scale fading can be well approximated by the Lognormal distribution, whereas the small‐scale fading in line‐of‐sight condition can be characterized as a Rician channel with a strong direct component and high K‐factors. On the other hand, in nonline‐of‐sight cases, the fading can be approximated by Nakagami or Rician distribution with low K‐factors. The cross‐polar discrimination is found between 14.2 and 22.5 dB, whereas the cross‐polar isolation is found between 12.8 and 21 dB, respectively. Finally, assessing the diversity performance, applying the maximal ratio combining technique, it is found that the left‐hand circular polarized transmission outperforms the right‐hand circular polarized transmission, providing gains up to 2.5 dB, especially in nonline‐of‐sight cases. The low‐diversity gains indicate that beamforming would be preferable to be applied in the specific channel.
Ethoxy‐Ester Functionalized Imidazolium based Ionic Liquids for Lithium Ion Batteries
Authors: Nirmale Trupti , Khupse Nageshwar , Gore Rohitkumar , Ambekar Jalindar , Kulkarni Milind , Varma Anjanikumar , Kale Bharat 
Published: June 2018

AbstractEthoxy ester functionalized imidazolium and bis(tri fluoromethanesulfonyl)imide based ionic liquids (ILs) are synthesized and considered as electrolyte for lithium ion batteries. The series of ethoxy ester functionalized ionic liquids were chosen with increase in ethoxy unit from one to three, followed by polymeric units. These ionic liquids provide both ester and ethoxy groups as interaction sites for Li+ ions enhancing the Li+ ion transportation, resulting in ionic conductivity of 10−3 Scm−1 at 25 °C, which is of 103 factor higher than ethoxy containing polyethylene oxide solid polymer electrolyte. It's noteworthy that the conductivity increases as ethoxy units are increased from one to three units, followed by a decrease for the polymeric ethoxy unit. Electrochemical stability window of these ionic liquids improves as the ethoxy groups are added to imidazolium cation. The Li/LiFePO4 cell fabricated with [ME3AMIm][TFSI] electrolyte shows good initial discharge capacity of 98.5 mAhg−1 at 0.05 C‐rate at room temperature, which gradually decreases with cycling. Systematic investigation of electrode surfaces by using SEM and EDX shows deposition of passivation layers on their surfaces. Ionic liquids fabricated by this facile method provide a promising model system for understanding the molecular interactions in promoting the lithium‐ion conduction mechanism. The advantages and the limits associated to series of ionic liquid electrolytes are critically investigated.
Synthesis of γ‐Valerolactone from Levulinic Acid and Formic Acid over Mg‐Al Hydrotalcite Like Compound
Authors: Hussain SK. , Velisoju Vijay Kumar , Rajan N. Pethan , Kumar Balla Putra , Chary Komandur V. R. 
Published: June 2018

AbstractCatalytic transformation of levulinic acid (LA) with in situ hydrogen transfer from formic acid (FA) into γ‐valerolactone (GVL) was investigated over calcined Mg‐Al hydrotalcite catalysts under atmospheric N2 pressure. Several catalysts containing different Mg/Al mole ratio in between 1:4 to 7:1 were synthesized by co‐precipitation method. The catalytic performances of calcined Mg/Al hydrotalcite during LA hydrogenation were found to be much higher than pure magnesia (MgO) and physical mixture samples of MgO‐Al2O3. Pure MgO exhibited higher activity in the initial hours but a gradual deactivation was noticed during the course of reaction time. Under the optimised reaction conditions, the calcined Mg/Al hydrotalcite catalyst with Mg/Al ratio of 3:1 exhibited superior performance with high GVL selectivity of 98% and total conversion of LA till 10 h of reaction time. The synthesised catalysts were characterized by various spectroscopic and adsorption techniques. The catalytic activity results during hydrogenation are well supported by means of the findings of characterization of the catalysts.
Cobalt(I)‐Catalyzed Cycloaddition of Functionally Substituted Alkynes and 1,3‐Diynes to 1,3,5,7‐Cyclooctatetraene in the Synthesis of Bicyclo[4.2.2]deca‐2,4,7,9‐tetraenes
Authors: D'yakonov Vladimir A. , Kadikova Gulnara N. , Gazizullina Guzel F. , Dzhemilev Usein M. 
Published: June 2018

AbstractThe [6π+2π]‐cycloaddition of O‐, S‐, N‐, Hal‐, and Si‐containing alkynes and 1,3‐diynes to 1,3,5,7‐cyclooctatetraene was accomplished for the first time using a Co(acac)2‐based four‐component catalytic system [Co(acac)2/dppe/Zn/ZnI2] to give previously undescribed functionally substituted bicyclo[4.2.2]deca‐2,4,7,9‐tetraenes in 72–95% yields. These products are of interest as key monomers for the synthesis of natural and synthetic biologically active compounds.
Natural Product Inspired Topology Directed Synthesis of Hybrid Macrocyclic Compounds: A Simple Approach to Natural Product Analogues
Authors: Gade Narendar Reddy , Iqbal Javed 
Published: June 2018

AbstractHerein we report a new approach of designing natural product‐like macrolide analogues by combining the critical structural features of two different class of natural products. These critical structural features are structural motifs that are commonly present in each class of selected family of natural products. These molecules are synthesized by using Steglich esterification and ring‐closing metathesis as key reactions.
A parallel portfolio approach to configuration optimization for large software product lines
Authors: Shi Kai , Yu Huiqun , Guo Jianmei , Fan Guisheng , Yang Xingguang 
Published: June 2018

SummarySoftware product line (SPL) engineering demands for optimal or near‐optimal products that balance multiple often competing and conflicting objectives. A major challenge for large SPLs is to efficiently explore a huge space of various products and satisfy a large number of predefined constraints simultaneously. To improve the optimality and convergence speed, we propose a parallel portfolio approach, called IBEAPORT, which designs three algorithm variants by incorporating constraint solving into the indicator‐based evolutionary algorithm in different ways and performs these variants by utilizing parallelization techniques. Our approach utilizes the exploration capabilities of different algorithms and improves optimality as far as possible within a limited time budget. We evaluate our approach on five large‐scale real‐world SPLs. Empirical results demonstrate that our approach significantly outperforms the state of the art for all five SPLs on a quality indicator and a diversity indicator. Moreover, IBEAPORT quickly converges to a relatively stable hypervolume value even for the largest SPL with 6888 features.
Microaggressions and Social Class Identity in Higher Education and Student Affairs
Authors: Locke Leslie Ann , Trolian Teniell L. 
Published: June 2018

AbstractIn this chapter, we discuss microaggressions, or the everyday (and often unintended) incidents of discrimination that individuals from marginalized or underserved groups experience on college campuses as they relate to students’ social class identities—or simply, class‐based prejudices.
Reducing indwelling urinary catheter use through staged introduction of electronic clinical decision support in a multicenter hospital system
Authors: Youngerman Brett E. , Salmasian Hojjat , Carter Eileen J. , Loftus Michael L. , Perotte Rimma , Ross Barbara G. , Furuya E. Yoko , Green Robert A. , Vawdrey David K. 
Published: June 2018

ObjectiveTo integrate electronic clinical decision support tools into clinical practice and to evaluate the impact on indwelling urinary catheter (IUC) use and catheter-associated urinary tract infections (CAUTIs).Design, Setting, and ParticipantsThis 4-phase observational study included all inpatients at a multicampus, academic medical center between 2011 and 2015.InterventionsPhase 1 comprised best practices training and standardization of electronic documentation. Phase 2 comprised real-time electronic tracking of IUC duration. In phase 3, a triggered alert reminded clinicians of IUC duration. In phase 4, a new IUC order (1) introduced automated order expiration and (2) required consideration of alternatives and selection of an appropriate indication.ResultsOverall, 2,121 CAUTIs, 179,070 new catheters, 643,055 catheter days, and 2,186 reinsertions occurred in 3·85 million hospitalized patient days during the study period. The CAUTI rate per 10,000 patient days decreased incrementally in each phase from 9·06 in phase 1 to 1·65 in phase 4 (relative risk [RR], 0·182; 95% confidence interval [CI], 0·153–0·216; P<·001). New catheters per 1,000 patient days declined from 53·4 in phase 1 to 39·5 in phase 4 (RR, 0·740; 95% CI, 0·730; P<·001), and catheter days per 1,000 patient days decreased from 194·5 in phase 1 to 140·7 in phase 4 (RR, 0·723; 95% CI, 0·719–0·728; P<·001). The reinsertion rate declined from 3·66% in phase 1 to 3·25% in phase 4 (RR, 0·894; 95% CI, 0·834–0·959; P=·0017).ConclusionsThe phased introduction of decision support tools was associated with progressive declines in new catheters, total catheter days, and CAUTIs. Clinical decision support tools offer a viable and scalable intervention to target hospital-wide IUC use and hold promise for other quality improvement initiatives.
Advances and challenges in barcoding of microbes, parasites, and their vectors and reservoirs
Authors: MORAND SERGE 
Published: June 2018

SUMMARYDNA barcoding is now a common tool in parasitology and epidemiology, which require good methods for identification not only of parasites and pathogens but vectors and reservoirs. This special issue presents some advances and challenges in barcoding of microbes, parasites, and their vectors and reservoirs. DNA barcoding found new applications in disease ecology, conservation parasitology, environmental parasitology and in paleoparasitology. New technologies such as next-generation sequencing and matrix-assisted laser desorption–ionization time-of-flight have made it now possible to investigate large samples of specimens. By allowing the investigation of parasites at the interface between environment, biodiversity, animal and human health, barcoding and biobanking have important policy outcomes as well as ethics and legal implications. The special issue ‘Advances and challenges in the barcoding of parasites, vectors and reservoirs’ illustrates some recent advances and proposes new avenues for research in barcoding in parasitology.
Pentecostal Identity and Citizen Engagement in Sub-Saharan Africa: New Evidence from Zambia
Authors: Sperber Elizabeth , Hern Erin 
Published: June 2018

AbstractSince the 1980s, Pentecostal and other born again Christian movements have become increasingly prominent in the public spheres of many sub-Saharan African states. A dearth of reliable survey data has constrained investigation of the potential influence of these religious movements on political attitudes and participation. This article analyzes original survey data from Zambia, a majority-Christian nation. These data, from a stratified random sample of 1,500 Zambians, indicate that Pentecostals do in fact share partisan preferences and report higher levels of political interest and participation than other Christians. They are less likely, however, to contact elected officials—a finding that accords with ethnographic accounts of Pentecostal pastors as political interlocutors for their politically mobilized congregations. We further contextualize and explore the external validity of our findings using cross-national survey data collected by the Pew Forum (2010,N = 9,500). We conclude by underscoring the value of further survey research on religion and politics in the region.
Three‐Dimensional Magnetohydrodynamic Simulations of the Solar Wind Interaction With a Hyperfast‐Rotating Uranus
Authors: Griton L. , Pantellini F. , Meliani Z. 
Published: June 2018

AbstractWe present magnetohydrodynamic simulations of a fast‐rotating planetary magnetosphere reminiscent of the planet Uranus at solstice, that is, with the spin axis pointing to the Sun. We impose a 10 times faster rotation than for Uranus, in order to emphasize the effects of rotation on the magnetospheric tail without the need of an excessively large simulation domain while keeping the qualitative aspects of a supersonic magnetized solar wind interacting with a fast‐rotating magnetosphere. We find that a complex helical Alfvénic structure propagates downstream at a velocity exceeding the plasma velocity in the magnetosheath. Similarly, the reconnection regions, which mediate the interaction of the planetary magnetic field and the interplanetary magnetic field, do also form a helical structure with the same downstream velocity but a 2 times larger pitch. We speculate that the magnetic field of the helical structure connected to the interplanetary magnetic field asymptotically reduces the phase velocity of the helical structure toward the tailward velocity in the magnetosheath. For our simulations we use the MPI‐AMRVAC code which we enhanced with a time‐dependent background magnetic field in the splitting of the magnetic field.
Shergottite Northwest Africa 6963: A Pyroxene‐Cumulate Martian Gabbro
Authors: Filiberto Justin , Gross Juliane , Udry Arya , Trela Jarek , Wittmann Axel , Cannon Kevin M. , Penniston‐Dorland Sarah , Ash Richard , Hamilton Victoria E. , Meado Andrea L. , Carpenter Paul , Jolliff Brad , Ferré Eric C. 
Published: June 2018

AbstractNorthwest Africa (NWA) 6963 was found in Guelmim‐Es‐Semara, Morocco, and based on its bulk chemistry and oxygen isotopes, it was classified as a Martian meteorite. On the basis of a preliminary study of the textures and crystal sizes, it was resubclassified as a gabbroic shergottite because of the similarity with terrestrial and lunar gabbros. However, the previous work was not a quantitative investigation of NWA 6963; to supplement the original resubclassification and enable full comparison between this and other Martian samples; here we investigate the mineralogy, petrology, geochemistry, quantitative textural analyses, and spectral properties of gabbroic shergottite NWA 6963 to constrain its petrogenesis, including the depth of emplacement (i.e., base of a flow versus crustal intrusion). NWA 6963 is an enriched shergottite with similar mineralogy to the basaltic shergottites but importantly does not contain any fine‐grained mesostasis. Consistent with the mineralogy, the reflectance (visible/near‐infrared and thermal infrared) spectrum of powdered NWA 6963 is similar to other shergottites because they are all dominated by pyroxene, but its reflectance is distinct in terms of albedo and spectral contrast due to its gabbroic texture. NWA 6963 represents a partial cumulate gabbro that is associated with the basaltic shergottites. Therefore, NWA 6963 could represent a hypabyssal intrusive feeder dike system for the basaltic shergottites that erupted on the surface.
CDKN2A inhibits formation of homotypic cell-in-cell structures
Authors: Liang Jianqing , Fan Jie , Wang Manna , Niu Zubiao , Zhang Zhengrong , Yuan Long , Tai Yanhong , Chen Zhaolie , Song Santai , Wang Xiaoning , Liu Xiaoqing , Huang Hongyan , Sun Qiang 
Published: June 2018

AbstractCell-in-cell (CIC) structures, characterized by enclosure of one or more cells within another cell, were extensively documented in human cancers. Although elevated CIC formation was found in cancers with CDKN2A inactivation, a causal link between them remains to be established. We reported here that inhibiting CDKN2A expression effectively promoted homotypic CIC formation, whereas ectopic overexpression of p16INK4a or p14ARF, two proteins encoded by CDKN2A gene, significantly suppressed CIC formation in MCF7 cells. The regulation of CIC formation by CDKN2A was tightly correlated with subcellular redistribution of E-cadherin, F-actin rearrangement and reduced phosphorylation of myosin light chain 2 (p-MLC2), consistent with which, CDKN2A expression imparted cells winner/outer identity in competition assay. Moreover, CIC formation negatively correlates with p16INK4a expression in human breast cancers. Thus, our work identifies CDKN2A as the first tumor suppressor whose inactivation promotes homotypic CIC formation in human cancer cells.
XK-related protein 5 (XKR5) is a novel negative regulator of KIT/D816V-mediated transformation
Authors: Sun Jianmin , Thingholm Tine , Højrup Peter , Rönnstrand Lars 
Published: June 2018

AbstractIn order to investigate the molecular mechanisms by which the oncogenic mutant KIT/D816V causes transformation of cells, we investigated proteins that selectively bind KIT/D816V, but not wild-type KIT, as potential mediators of transformation. By mass spectrometry several proteins were identified, among them a previously uncharacterized protein denoted XKR5 (XK-related protein 5), which is related to the X Kell blood group proteins. We could demonstrate that interaction between XKR5 and KIT/D816V leads to phosphorylation of XKR5 at Tyr 369, Tyr487, and Tyr 543. Tyrosine phosphorylated XKR5 acts as a negative regulator of KIT signaling, which leads to downregulation of phosphorylation of ERK, AKT, and p38. This led to reduced proliferation and colony forming capacity in semi-solid medium. Taken together, our data demonstrate that XKR5 is a novel type of negative regulator of KIT-mediated transformation.
Involvement of Burkholderiaceae and sulfurous volatiles in disease-suppressive soils
Authors: Carrión Víctor J , Cordovez Viviane , Tyc Olaf , Etalo Desalegn W , de Bruijn Irene , de Jager Victor C L , Medema Marnix H , Eberl Leo , Raaijmakers Jos M 
Published: June 2018

Abstract
Disease-suppressive soils are ecosystems in which plants suffer less from root infections due to the activities of specific microbial consortia. The characteristics of soils suppressive to specific fungal root pathogens are comparable to those of adaptive immunity in animals, as reported by Raaijmakers and Mazzola (Science 352:1392–3, 2016), but the mechanisms and microbial species involved in the soil suppressiveness are largely unknown. Previous taxonomic and metatranscriptome analyses of a soil suppressive to the fungal root pathogen Rhizoctonia solani revealed that members of the Burkholderiaceae family were more abundant and more active in suppressive than in non-suppressive soils. Here, isolation, phylogeny, and soil bioassays revealed a significant disease-suppressive activity for representative isolates of Burkholderia pyrrocinia, Paraburkholderia caledonica, P. graminis, P. hospita, and P. terricola. In vitro antifungal activity was only observed for P. graminis. Comparative genomics and metabolite profiling further showed that the antifungal activity of P. graminis PHS1 was associated with the production of sulfurous volatile compounds encoded by genes not found in the other four genera. Site-directed mutagenesis of two of these genes, encoding a dimethyl sulfoxide reductase and a cysteine desulfurase, resulted in a loss of antifungal activity both in vitro and in situ. These results indicate that specific members of the Burkholderiaceae family contribute to soil suppressiveness via the production of sulfurous volatile compounds.
The art of building bone: emerging role of chondrocyte-to-osteoblast transdifferentiation in endochondral ossification
Authors: Aghajanian Patrick , Mohan Subburaman 
Published: June 2018

AbstractThere is a worldwide epidemic of skeletal diseases causing not only a public health issue but also accounting for a sizable portion of healthcare expenditures. The vertebrate skeleton is known to be formed by mesenchymal cells condensing into tissue elements (patterning phase) followed by their differentiation into cartilage (chondrocytes) or bone (osteoblasts) cells within the condensations. During the growth and remodeling phase, bone is formed directly via intramembranous ossification or through a cartilage to bone conversion via endochondral ossification routes. The canonical pathway of the endochondral bone formation process involves apoptosis of hypertrophic chondrocytes followed by vascular invasion that brings in osteoclast precursors to remove cartilage and osteoblast precursors to form bone. However, there is now an emerging role for chondrocyte-to-osteoblast transdifferentiation in the endochondral ossification process. Although the concept of “transdifferentiation” per se is not recent, new data using a variety of techniques to follow the fate of chondrocytes in different bones during embryonic and post-natal growth as well as during fracture repair in adults have identified three different models for chondrocyte-to-osteoblast transdifferentiation (direct transdifferentiation, dedifferentiation to redifferentiation, and chondrocyte to osteogenic precursor). This review focuses on the emerging models of chondrocyte-to-osteoblast transdifferentiation and their implications for the treatment of skeletal diseases as well as the possible signaling pathways that contribute to chondrocyte-to-osteoblast transdifferentiation processes.
Unsupervised clustering and epigenetic classification of single cells
Authors: Zamanighomi Mahdi , Lin Zhixiang , Daley Timothy , Chen Xi , Duren Zhana , Schep Alicia , Greenleaf William J. , Wong Wing Hung 
Published: June 2018

AbstractCharacterizing epigenetic heterogeneity at the cellular level is a critical problem in the modern genomics era. Assays such as single cell ATAC-seq (scATAC-seq) offer an opportunity to interrogate cellular level epigenetic heterogeneity through patterns of variability in open chromatin. However, these assays exhibit technical variability that complicates clear classification and cell type identification in heterogeneous populations. We present scABC, an R package for the unsupervised clustering of single-cell epigenetic data, to classify scATAC-seq data and discover regions of open chromatin specific to cell identity.
Label-free detection of hypoxia-induced extracellular vesicle secretion from MCF-7 cells
Authors: Kilic Tugba , Valinhas Ana Teresa De Sousa , Wall Ivan , Renaud Philippe , Carrara Sandro 
Published: June 2018

AbstractNanoscale extracellular vesicles (EVs) including exosomes (50–150 nm membrane particles) have emerged as promising cancer biomarkers due to the carried genetic information about the parental cells. However the sensitive detection of these vesicles remains a challenge. Here we present a label-free electrochemical sensor to measure the EVs secretion levels of hypoxic and normoxic MCF-7 cells. The sensor design includes two consecutive steps; i) Au electrode surface functionalization for anti-CD81 Antibody and ii) EVs capture. The label-free detection of EVs was done via Differential Pulse Voltammetry (DPV) and Electrochemical Impedance Spectroscopy (EIS). The working linear range for the sensor was 102–109EVs/ml with an LOD 77 EVs/mL and 379 EVs/ml for EIS and DPV based detection. A blood-abundant protein, RhD was used for the selectivity test. In order to assess the performance of the biosensor, the level of EVs secretion by the human breast cancer MCF-7 cell line was compared with enzyme-linked immunosorbent assays (ELISA) and Nanoparticle Tracking Analysis (NTA). Designed label-free electrochemical sensors utilized for quantification of EVs secretion enhancement due to CoCl2-induced hypoxia and 1.23 fold increase with respect to normoxic conditions was found.