bluuebunny/crossref_metadata_2025_split huggingface dataset:
Diagnostic performance of endoscopic ultrasound-guided fine-needle aspiration for cystic and non-cystic pancreatic neuroendocrine tumors
Authors: Dhaliwal Amaninder Jeet Singh , Strosberg Jonathan R. , Centeno Barbara A. , Vignesh Shivakumar 
Published: July 2019

Abstract
Background and study aims Pancreatic neuroendocrine tumors (P-NENs) are rare tumors with malignant potential. Endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) has been shown to be superior to other imaging methods in preoperative localization and diagnosis of P-NENs. The objective of this study was to describe the EUS features of non-metastatic cystic and non-cystic P-NENs seen at a referral center and to evaluate the performance of EUS-FNA in diagnosis of P-NENs.
Patients and methods All patients with histologically confirmed, non-metastatic P-NENs, which underwent EUS-FNA prior to surgical resection at the Moffitt Cancer Center between Jan 2005 and Dec 2012 were included. Clinical, endoscopic and pathologic information was abstracted from electronic medical records.
Results Thirty-nine patients, all with non-functional P-NENs, were included in this study. Thirteen tumors were cystic and 26 were solid. Among the cystic tumors, 50 % were partly cystic and partly solid, and 50 % were fully cystic. The cystic tumors were more commonly seen at the body/tail, and the solid tumors were more uniformly distributed. Fluid could be aspirated from 50 % of the cystic tumors, all with a carcinoembryonic antigen level < 192 ng/mL. With surgical pathology as the gold standard, overall sensitivity of EUS-FNA in diagnosing cystic tumors was 62.5 %, and for solid tumors, 95 % (P < 0.03).
Conclusions EUS-FNA is much more sensitive in diagnosing solid P-NENs than cystic PNETs. Our results indicate that EUS-FNA may have higher sensitivity for diagnosis of cystic P-NENs than the reported sensitivity of EUS-FNA for all pancreatic cystic tumors.
First Experience with Fluorescence in Pediatric Laparoscopy
Authors: Fernández-Bautista Beatriz , Mata David Peláez , Parente Alberto , Pérez-Caballero Ramón , De Agustín Juan Carlos 
Published: July 2019

Background The use of intraoperative fluorescence images with indocyanine green (ICG) has recently been described as an aid in decision-making during surgical procedures in adults.We present our first experiences with different laparoscopic procedures performed in children using ICG fluorescence images.
Material and Method We have used ICG fluorescence imaging technique in varicocele ligation, two nephrectomies, cholecystectomy, and one case of aortocoronary fistula closure. All procedures were performed through a minimally invasive approach. A high definition camera equipped with a visible infrared light source and gray-scale vision technology was used.After injection of ICG before or during the laparoscopic procedure, precise identification of vascular anatomy and bile duct architecture were easily identified. Fluorescence helped to assess blood flow from the spermatic vessels, define the variability of renal vascularization, and determine the precise location of the aortocoronary fistula. Biliary excretion of the ICG allowed the definition of the biliary tract.
Conclusion Fluorescein-assisted images allowed a clear definition of the anatomy and safe surgical maneuvers during surgical procedures. The ICG imaging system seems to be simple and safe. Larger and more specific studies are needed to confirm its applicability, expand its indications, and address its advantages and disadvantages.
Late Diagnosis of Complete Colonic and Rectal Duplication in a Girl with an Anorectal Malformation
Authors: AbouZeid Amr AbdelHamid , Mohammad Shaimaa Abdelsattar , Ibrahim Sherif Elhussiny , Fagelnor Anas , Zaki Ahmad 
Published: July 2019

AbstractComplete colonic duplication is rare, and usually occurs as a part of the caudal duplication syndrome. In such cases, the diagnosis is clinically evident by the presence of two ani arranged side by side in the perineum, which is commonly associated with duplication of the external genitalia as well (double phallus or double vestibule). In this report, we present a special case of anorectal anomaly that was associated with complete tubular colonic duplication. The diagnosis was initially missed due to the uncommon sagittal arrangement of duplicated rectum: one rectum was ending externally into the perineum by rectoperineal fistula, while the other was hidden by its internal termination into the vagina. Our final diagnosis for this case was a variant of anorectal anomaly in the female, which was associated with complete colonic duplication. One colon (which was in the free mesenteric border) terminated anteriorly into the vagina as a part of a “short common channel” cloaca, while the other colon terminated by rectoperineal fistula. Although the anomaly seems to be rather complex and confusing, yet our case was associated with an excellent outcome due to the benign type of anorectal anomalies (rectoperineal fistula and “short common channel” cloaca) and absence of significant sacral dysplasia; in addition to adequate identification of the abnormal anatomy by appropriate investigations and the staged approach for surgical reconstruction.
Web-Based Bioinformatics Predictors: Recommendations to Assess Lysosomal Cholesterol Trafficking Diseases-Related Genes
Authors: López de Frutos Laura , Cebolla Jorge J. , Irún Pilar , Köhler Ralf , Giraldo Pilar 
Published: July 2019

Introduction The growing number of genetic variants of unknown significance (VUS) and availability of several in silico prediction tools make the evaluation of potentially deleterious gene variants challenging.
Materials and Methods We evaluated several programs and software to determine the one that can predict the impact of genetic variants found in lysosomal storage disorders (LSDs) caused by defects in cholesterol trafficking best. We evaluated the sensitivity, specificity, accuracy, precision, and Matthew's correlation coefficient of the most common software.
Results Our findings showed that for exonic variants, only MutPred1 reached 100% accuracy and generated the best predictions (sensitivity and accuracy = 1.00), whereas intronic variants, SROOGLE or Human Splicing Finder (HSF) generated the best predictions (sensitivity = 1.00, and accuracy = 1.00).
Discussion Next-generation sequencing substantially increased the number of detected genetic variants, most of which were considered to be VUS, creating a need for accurate pathogenicity prediction. The focus of the present study is the importance of accurately predicting LSDs, with majority of previously unreported specific mutations.
Conclusion We found that the best prediction tool for the NPC1, NPC2, and LIPA variants was MutPred1 for exonic regions and HSF and SROOGLE for intronic regions and splice sites.
Translating Research into Agile Development (TRIAD): Development of Electronic Health Record Tools for Primary Care Settings
Authors: Clark K. D. , Woodson T. T. , Holden R. J. , Gunn R. , Cohen D. J. 
Published: July 2019

Objectives This article describes a method for developing electronic health record (EHR) tools for use in primary care settings.
Methods The “Translating Research into Agile Development” (TRIAD) method relies on the close collaboration of researchers, end users, and development teams. This five-step method for designing a tailored EHR tool includes (1) assessment, observation, and documentation; (2) structured engagement for collaboration and iterative data collection; (3) data distillation; (4) developmental feedback from clinical team members on high-priority EHR needs and input on design prototypes and EHR functionality; and (5) agile scrum sprint cycles for prototype development.
Results The TRIAD method was used to modify an existing EHR for behavioral health clinicians (BHCs) embedded with primary care teams, called the BH e-Suite. The structured engagement processes stimulated discussions on how best to automate BHC screening tools and provide goal tracking functionality over time. Data distillation procedures rendered technical documents, with information on workflow steps, tasks, and associated challenges. In the developmental feedback phase, BHCs gave input on screening assessments, scoring needs, and other functionality to inform prototype feature development. Six 2-week sprint cycles were conducted to address three domains of prototype development: assessment and documentation needs, information retrieval, and monitoring and tracking. The BH e-Suite tool resulted with eight new EHR features to accommodate BHCs' needs.
Conclusion The TRIAD method can be used to develop EHR functionality to address the evolving needs of health professionals in primary care and other settings. The BH e-Suite was developed through TRIAD and was found to be acceptable, easy to use, and improved care delivery during pilot testing. The BH e-Suite was later adopted by OCHIN Inc., which provided the tool to its 640 community health centers. This suggests that the TRIAD method is a promising research and development approach.
Anterograde Amnesia as a Manifestation of Acute Type A Aortic Dissection
Authors: Stöllberger Claudia , Koller Julia , Finsterer Josef , Schauer Dominic , Ehrlich Marek 
Published: July 2019

Objectives Memory impairment has been only rarely reported in association with acute aortic dissection type A. We report a patient with pure anterograde amnesia and memory impairment of contents occurring after the event, accompanying acute aortic dissection type A.
Case Report A previously healthy 53-year-old Caucasian male was admitted because of sudden chest pain after having lifted a heavy object. Clinical examination and electrocardiogram showed no abnormalities. Since blood tests showed leukocytosis, anemia, and elevated D-dimer level, either pulmonary embolism or aortic dissection was suspected; therefore, computed tomography was suggested. The patient seemed disoriented to time, and neurologic investigation confirmed that the patient was disoriented to time; short time memory was severely impaired and concentration was reduced. An amnestic episode with anterograde amnesia was diagnosed. Computed tomography showed type A aortic dissection. A supracoronary replacement of the ascending aorta was performed. The patient was discharged on the 7th postoperative day. Three months postoperatively, the patient is clinically stable; however, amnesia for the interval between pain onset and cardiac surgery persists.
Conclusions Transient amnesia, usually considered a benign syndrome, may be more common than generally recognized in aortic dissection. The suspicion for aortic dissection or other cardiovascular emergencies is substantiated when amnesia is associated with sudden onset of chest pain, leukocytosis, and elevated D-dimer levels. Computed tomography of the aorta with contrast medium is the imaging method of choice to confirm or exclude the diagnosis.
Arthroscopically Assisted Bone Grafting Reduces Union Time of Scaphoid Nonunions Compared to Percutaneous Screw Fixation Alone
Authors: Gvozdenovic Robert , Joergensen Rasmus Wejnold , Joerring Stig , Jensen Claus Hjort 
Published: July 2019

Purpose Minimally invasive techniques have been recommended in the treatment of painful but stable scaphoid nonunions. The purpose of this study was to determine if arthroscopically assisted bone grafting provided superior results in healing as compared to percutaneous screw fixation.
Materials and Methods One hundred sixty-four consecutive patients with scaphoid nonunions were retrospectively analyzed. One hundred forty-eight patients were treated with the open grafting techniques either with iliac or distal radius bone, leaving 16 patients treated with minimally invasive surgery. In the group treated percutaneously (n = 8), the time from injury to surgery was 2.5 months (range: 2–4 months) and it was 27.3 months (range: 3–180 months) in the arthroscopic group (n = 8). The mean age was 39 years (range: 20–66) in the percutaneous group and 22 years (range: 16–32) in the arthroscopic group. In all cases, the Mini Acutrak headless fully threaded compression screw was used. Healing was assessed clinically and radiographically at a minimum follow-up of 12 weeks, mean 7 months (range: 3–12 months). Data were calculated with two-tailed Mann–Whitney U test based on p-value of < 0.05 that was considered statistically significant.
Results We recorded no complications in any of the groups. Patients treated arthroscopically received cancellous bone grafting from the distal radius and all patients but one healed at a median of 7.8 weeks (range: 5–18 weeks). Seven patients in the percutaneous group healed at a mean of 10.5 weeks (range: 7–24 weeks), thus leaving one patient from each group without achieving union. Mann–Whitney U test showed the U value of 11, the critical value of U to be 13 (p < 0.05), thus significantly faster healing was observed in the arthroscopically treated group.
Conclusions Arthroscopically treated patients achieved faster healing despite shorter time to surgery in the percutaneous group. Local bone grafting is considered as the main reason for this outcome. Younger population in the arthroscopically treated group may have influenced the result.
Level of Evidence This is a Level III comparative study.
Stochastic geometry sensing and polarization in a lipid kinase–phosphatase competitive reaction
Authors: Hansen Scott D. , Huang William Y. C. , Lee Young Kwang , Bieling Peter , Christensen Sune M. , Groves Jay T. 
Published: July 2019

Significance
Spatial gradients of phosphatidylinositol phosphate (PIP) lipids in the cell membrane regulate a variety of cellular processes, including endocytosis, phagocytosis, and cell migration. The molecules that control these cellular processes must navigate a diverse range of geometric constraints, including membrane sheets, blebs, vesicles, and tubules. Stochastic geometry sensing provides a mechanism for controlling spatial patterning of molecules on cellular membranes, by exploiting differences in molecular copy number and kinetic asymmetries between opposing enzymatic reactions. The generality of the stochastic geometry-sensing mechanism suggests that such effects are likely to occur in cellular signaling systems.
Dialogical power negotiations in conflict mediation
Authors: Bijnen Emma van 
Published: July 2019

Abstract
In this study, mediator – party power dynamics in workplace disputes mediation dialogues are examined. Adopting
Gramsci’s concept of hegemony (e.g. 2005) and Foucault′s notion that power is not fixed
in dialogues, but constantly negotiated by participants (e.g. Foucault 1980), the
analyses show that the power dynamics shift in the mediation setting when mediators subordinate dominant parties and enforce their
own formalized power as procedural guides to design (Aakhus 2003, 2007) a favorable context for conflict resolution. When their procedural power is threatened, mediators
may use specific devices in their interventions that correlate with the four devices – interruption, enforcing explicitness, topic
control, and formulation – Fairclough (1989, 135–137) states can be used by dominant
participants to control weaker parties in dialogues.
Time tells a story
Authors: Abuarrah Sufyan 
Published: July 2019

AbstractThis study provides a synthesized perspective on the functions and ideological orientation of time adverbials as (re)situated in their socio-political contexts in five speeches by the Palestinian President Mahmoud Abbas at the UN. By analysing adverbials of truncated, extending, and fixed time references, the study reveals some systematic ideological formulations of conflict and resolution in the Palestinian political discourse. Adverbials of truncated and extending time are incongruous and generate a sense of interpretive dissonance. The truncated sense is embedded and more particular, thus counteracting the extending time which is established as more progressive, perseverant and consistent. This represents power asymmetries and different ideological orientations to conflict and resolution. Adverbials of fixed time, however, are transformative; they grant an end to a clash of ideologies due to the conflict between truncated and extending temporalities, and therefore resurrect a discourse that is based on equity and justice.
What makes a positive experience?
Authors: de la O Hernández-López María 
Published: July 2019

Abstract‘Sharing economy’ platforms such as Airbnb have recently given rise to new travel trends in which electronic word of mouth and interpersonal contact are central. This study examines 90 positive reviews, with a threefold objective: first, analyse what makes Airbnb a social platform; second, understand online/offline rapport enhancement prior to and during the Airbnb experience; and third, examine the main rapport enhancement strategies in users’ evaluations. The results show that while reviewers place great importance on transactional wants before the experience, during face-to-face contact sociality rights become more important. After the Airbnb experience, however, the main rapport strategies point to enhancing the addressee’s face, while identity is constantly co-constructed. The present study intends to bring to the fore the function of positive rapport in the Airbnb experience, in an online system in which the management of communicative skills may be the main tool for success – or failure.
Bacteria with natural chemotaxis towards methanol revealed by chemotaxis fishing technique
Authors: Tola Yosef Hamba , Fujitani Yoshiko , Tani Akio 
Published: July 2019

ABSTRACT
Motile bacteria often exhibit chemotaxis toward favorable compounds. However, the diversity of bacteria that are attracted to a given substance is largely unknown. This study aimed to reveal the diversity of bacteria with natural chemotaxis towards methanol. We tried to enrich environmental chemotactic bacteria using a glass capillary that is half-filled with methanol solidified with agarose as a trap (“chemotaxis fishing”). The pilot experiment using methanol-chemotactic Methylobacterium aquaticum strain 22A enriched the cells by 46-fold. The method was then applied to bacterial suspensions from paddy water and plants. Depending on the isolation sources and the methods of motility induction, methylotrophic bacteria were enriched 1.2–330-fold. The fished isolates belong to 32 species in 18 genera, mainly containing Acinetobacter, Methylobacterium and Pseudomonas species. Our chemotaxis fishing unveiled a part of diversity of the bacteria with natural chemotaxis towards methanol.
Design and Construction of Security Monitoring System for Optical Fibre Communications
Authors: Chyad Radhi M , Ali Alaa H , Khalef Nihaya H , Hamad Ahmed A , Mahmood Aseel I , Mahdi Bushra R , Rashid Wasfi H , Shaiee Noon K 
Published: July 2019

Abstract
Despite the fact that security monitoring system is high in communications using optical fibre, communications are still easy to be penetrated and information could be stolen. Companies have developed tools and equipment bugging and stealing data sent over optical fibre network, especially in those areas experiencing high loss of optical signal. Thus, it has become necessary to design and construct monitoring and warning system to avoid penetration or access to optical cable network. It is more convenient to install field application and control security system for optical cable communications that are parallel with the oil transportation pipeline. The project aims to sending a signal light with low-power ability and sensitivity by using Wavelengths Division Multiplexer (WDM), Dense Wavelengths Division Multiplexer (DWDM), and Optical Time Domain Reflect Meter (OTDR) as measurement and Optical Spectrum Analyser as a detector (OSA). The system is then used in monitoring oil and gas pipeline leakage or muggers and monitoring damage in the body of dams by adding fibre optics sensors. The sensors are to be distributed on the surface and connected with each other in the form of retinal rings to reach the receiving devices. It could also monitor ranges reaching to up about a hundred kilometres.
Graphene Effect on the Mechanical Properties of Poly (Ethylene Oxide)/ Graphene Oxide Nanocomposites Using Ultrasound Technique
Authors: Al-Bermany Ehssan , Qais Dhefaf , Al-Rubaye Shaymaa 
Published: July 2019

Abstract
Graphene is one of the most important materials that have attracted the attention of scientists and engineers because of its unique properties. Graphene oxide was used with different concentrations (0.5, 1, 1.5 and 2 wt%) that were mixed with high molecular weight polymer to prepare several models of PEO-GO nanocomposites using solution casting methods. Some of the properties of the samples, including the density, viscosity and ultrasonic velocity were measured using different technologies such as the ultrasound (US). The results showed a change and significant enhancements in these properties with the increase of graphene oxide concentrations in the matrix. Where, the viscosity increased up to 112.5 %, meanwhile the mechanical properties enhanced by 86.2 % and 719 % of ultrasonic velocity and bulk modules, respectively. Most of the mechanical properties were increased exponentially with the increase of GO concentrations. The results found that the best concentration of (GO) was (1.5 wt%) that greatly enhanced the mechanical properties in this study. SEM images presented a clear change in the fracture surface that showed a smooth surface and homogeneous dispersion of the GO nanosheets into the PEO matrix.
Structural and Optical Properties of Boron Doped Cadmium Oxide
Authors: Khadayeir Abdulhussain A , Hassan Ehssan S , Chiad Sami S , Habubi Nadir F , Abass Khalid H , Rahid Maher H , Mubarak Tahseen H , Dawod Mohamed O , Al-Baidhany Ismaeel A 
Published: July 2019

Abstract
Thin films of transparent and conductive CdO and B1,3)w% doped cadmium oxide (CdO: B) (1 and 3) wt %, have been deposited using chemical spray pyrolysis (CSP)) technique on glass substrate temperature of 300°C. Microstructural analysis indicates that X-ray diffraction study shows that the obtained films were polycrystalline. The preferred orientation was along the direction (200) and that the average crystallite size increases with the increasing B content. Morphological properties were studied, by scanning electron microscope (SEM) and atomic force microscopy (AFM) which reveals that the grains have a similar column shape. UV-visible transmission spectroscopy reveal that the prepared thin films are transparent in the visible range, The value of the optical band gap obtained shows a slight increase in its values from 2.43 eV to 2.45 eV as B concentration increasing.