bluuebunny/crossref_metadata_2025_split huggingface dataset:
De Participatieve Waarde Evaluatie: ervaringen met een nieuwe vorm van grootschalige burgerparticipatie
Authors: Mouter Niek , Beumer Mark 
Published: November 2024

The Participatory Value Evaluation: experiences with a new form of large-scale citizen participation
The Participatory Value Evaluation (the Dutch abbreviation is PWE for ‘Participatieve Waarde Evaluatie’) is a democratic innovation that has been applied more than 80 times in the Netherlands. The essence of a PWE is that residents take the place of a policymaker and give advice on policy dilemmas. This article determines the distinguishing elements of a PWE by comparing PWE with other methods such as the referendum and the citizens’ council. In addition, this article describes experiences with the PWE of policymakers and participants in nine cases. Policymakers appreciate that the PWEs provide concrete, usable insights. Because participants in the PWE experience the same dilemma as policymakers, their advice can be translated into policy more easily. Policymakers appreciate that a large and representative group participates in the PWE. This also includes constituents that they normally do not see at offline participation moments such as residents’ evenings. For example, people with a nuanced opinion (‘the silent middle’). Policymakers consider PWE to be an efficient citizen participation method and appreciate the focus that the design process of a PWE provides. Participants are generally very positive about their participation in the PWE. However, there is a group of participants who have a greater need to provide advice outside the policy options offered.
Gluren bij de buren: hoe waarderen Nederlandse en Vlaamse gemeenteraadsleden diverse vormen van burgerparticipatie?
Authors: Goutry Willem , De Smedt Nina , Wagenaar Charlotte 
Published: November 2024

Spying on the neighbours: how do Dutch and Flemish municipal councillors value various forms of citizen participation
In the Netherlands and Flanders (Belgium), the municipal council plays an important role in promoting various forms of citizen participation. It is therefore important to know how council members view different forms of participation. In this contribution, we mainly focus on two forms. On the one hand, we will look at deliberative forms, such as citizen panels and citizen summits, in which citizens discuss a specific theme and ultimately provide advice. On the other hand, we study aggregative forms, such as referendums, in which citizens can individually make their voices heard on a policy proposal through a vote. Both forms have the potential to strengthen democratic processes and increase citizen involvement, but the way in which they are deployed and followed up depends on political support. Our findings show that council members in the Netherlands and Flanders seem to have more support for deliberative forms of participation than for aggregative forms. This support translates into various advantages and disadvantages that municipal council members identify for both forms and which we link to democratic values: inclusion, citizenship, influence on policy, deliberation and legitimacy.
Patch Clamping in Combination with Fluorescence Is a Reliable Technique for Studying Pore-Forming Ion Channels
Authors: Pegas Teixeira Guilherme , Rocha Leandro , Xavier Faria Robson 
Published: November 2024

Ion channels play essential roles in the functional balance of cells, whether in the context of electrical balance or in the activation of signaling pathways for specific processes. Pore formation is a notable feature of several channels, such as P2X7R, TRPV1, TRPA1, connexins, pannexin−1, and Maxi-anion, which significantly increase the permeability of the plasma membrane, allowing high ionic conductance and molecular weights of up to 900–1000 Da. Exploring the biophysical and physicochemical properties of these receptors is an important way to better understand their physiological and pathological functions. To this end, the patch clamp electrophysiology technique and methods using cationic and anionic fluorescent dyes are used to study these channels, making it possible to estimate and quantify pore size, ionic conductance, and selectivity. Therefore, in this work, we address different pore-forming channels through electrophysiological and fluorescence investigations of the physical and chemical properties of these large conductance channels.
Business Ethics &amp; Promoting Sustainable Social Initiatives (Leadership, Culture and Social Responsibility)
Authors: Mohammed Dr. Zhehat Safar 
Published: November 2024

The aim of this thesis is to investigate the impact of transformational, transactional, and laissez-faire (Full Range Leadership Theory) and authentic leadership styles on corporate social responsibility (CSR) and organizational culture as a mediator variable in the relationships between them. Data were collected from 254 respondents in 12 investment corporations in 4 industries (oil and gas, construction, telecommunications, and foods) in Erbil-Kurdistan Region of Iraq. Both the MLQ and ALQ scales were used, and the statistical appropriateness of the EFA was examined for testing the theoretical model and proving the reliability of the study constructs. Multiple and simple linear regression analysis with ANOVA analysis of variance techniques was applied to examine the study hypotheses and verify the relationships among leadership styles, CSR, and organizational culture. The study's findings revealed that most of the behaviors of transformational and authentic leadership have a positive effect on the dimensions of CSR as well as the dimensions of organizational culture. Also, organizational culture dimensions showed a positive effect on the dimensions of CSR. While transactional leadership results showed most dimensions had a negative effect on the dimensions of CSR and a positive effect on the dimensions of organizational culture, laissez-faire results indicated a negative effect on all dimensions of CSR and a negative effect on all dimensions of organizational culture. The results of mediation indicated a partial mediation impact of organizational culture in the relationship between transformational and authentic leadership styles and CSR. Also, it was revealed that organizational culture had a full mediation in the relationship between transactional leadership, laissez-faire, and CSR. Lastly, the study concluded by offering several implications and recommendations for concerned parties and future research.
Sustrato congénito y destrucción multivalvular por Enterococcus Faecalis.
Authors: Barrio Nuñez Eduardo Fernando , López Mendoza Richard , Medina Juan , Macías Juan Pablo 
Published: November 2024

Introducción: La endocarditis infecciosa no tratada tiene una mortalidad cercana al 20%. Su incidencia ha aumento en los últimos años. Las cardiopatías congénitas del adulto cuya incidencia aumenta constantemente, constituyen un factor de riesgo permanente de endocarditis infecciosa. La epidemiología de los microorganismos causales en cardiopatías congénitas no difiere de la endocarditis adquirida. La endocarditis derecha es más frecuente en este grupo.
Caso clínico: Mujer de 58 años con hipertensión arterial y comunicación interventricular perimembranosa restrictiva. Presenta 1 mes de evolución de fiebre, asociada a extracción de 2 molares. Fue tratada con antiobioticoterapia oral en primera instancia y luego intravenosa. Durante la hospitalización se aisla Enterococcus Faecalis en hemocultivo. En las últimas 24 horas se asocia disnea de pequeños esfuerzos, con la presencia de un soplo holodiastólico a nivel aórtico y soplo hosistólico a nivel tricuspídeo. Con signos de congestión pulmonar, se realiza screening incial con ecocardiograma evidenciando insuficiencia aortica de grado severo y tricuspidea torrencial con presencia de vegetaciones a nivel aórtico y tricuspideo (>10 mm) por lo que se realiza ETE evidenciando abceso periaórtico(17x9 mm) requiriendo intervención quirúrgica emergente con doble reemplazo valvular aórtico y tricuspídeo con bioprótesis, intraoperatoriamente intercurre con bloqueo auriculoventricular completo que se prologa por 72 horas, por lo que se colocó un marcapaso Micra con evolución favorable.
Conclusiones: El implante transcateter del Marcapaso Micra (sistema sin cables) es una opción eficaz en pacientes con endocarditis infecciosa que han requerido reemplazo valvular urgente y han presentando trastornos de conducción con infección aún activa en sangre. La profilaxis antibiótica esta recomendada para pacientes con sustrato congénito que se someten a procedimientos dentales de riesgo alto. Dado el impacto de la infección relacionada con los dispositivos electrónicos implantables en la morbilidad, la mortalidad y el costo, estos hallazgos tienen una importancia clínica significativa.
The Effect of Service Quality on Patient Satisfaction at King Faisal Hospital in Saudi Arabia
Authors: Alabbas Anood Matooq , Alzahrani Faisal Essa , Alsulami Ahmed Amer , Almogati Mohammed Wasl , Alhutayrashi Yaseer Saeed , Althobaiti Abdulrahim Sharaf , Alotaibi Moshari Mansour , Alotaibi Mufreh Aali , Alofi Adil Saleh , Alsarawani Talal Meshal , Alotaibi Ahmed Nawwar , Allehyani Maher Mohammed , Allehyani Mamdouh Mohammed , Almatrafi Adil Fawzan , Alotaibi Abdullah Obaid , Almotairi Yaseer Marzoug , Almalki Hezam Safar , Alrefai Muhanna Salem , Aloufi Yousef Saeed , Algnawi Ali Sadag , Albaqami Abdulaziz Sultan 
Published: November 2024

The healthcare sector offers medical services to those in need of medical attention. Clinics, hospitals, and community health services are all part of the health services sector. One healthcare facility crucial to enhancing the general state of public health is the hospital. In the healthcare sector, achieving patient satisfaction depends heavily on service quality. As a result of the growing degree of competition, hospitals are becoming more conscious of how important it is to give their patients the highest caliber of care. Aim: to investigate the impact of Service Quality (SQ) on Patient Satisfaction (PSAT). Methodology: a quantitative cross-sectional correlational study, a convenience sample of 380 in-patients receiving treatment at a governmental hospital, King Faisal Hospital in Saudi Arabia. Data was collected by using two questionnaires: Service Quality (SQ) and patient satisfaction (PSAT) with data analysis conducted using Amoss26 and SPSS26. Conclusion: The findings revealed Service Quality (SQ) positively influenced patient satisfaction. Limitation: Since there are fewer studies on Service Quality (SQ) in the healthcare sector than in manufacturing industries, this research substantially contributes to existing literature and merits additional study. Furthermore, this research offers significant perspectives for managers in the healthcare industry about strategic planning and decision-making procedures.
Legitimidade ativa ad causam do sindicato como substituto processual
Authors: Bochi Igor 
Published: November 2024

As entidades sindicais têm como objetivos primordiais defender e representar os integrantes de sua categoria, atuando na tutela dos seus direitos também em juízo. Nesse contexto de ampla ou irrestrita legitimidade, objetiva-se estabelecer os balizadores de atuação judicial sindical, assim como verificar a possibilidade de limitação da substituição processual em casos pontuais ou em situações extremas. Utiliza-se, para tanto, o método de abordagem dedutivo, por meio de revisão bibliográfica e jurisprudencial, coletada de livros, periódicos, artigos acadêmicos e pesquisa jurisprudencial. Na primeira seção, abordam-se os direitos coletivos em sentido amplo, abrangendo os direitos difusos, coletivos em sentido estrito e individuais homogêneos. Na segunda seção, discorre-se acerca da legitimação, sobretudo no que concerne à legitimidade extraordinária e a substituição processual, com o enfoque na atuação sindical na defesa dos direitos coletivos em sentido amplo. Por fim, levanta-se uma hipótese de estreitamento formal da legitimidade sindical em casos com particularidades extremas. Conclui-se, por fim, amparado pelas decisões dos Tribunais superiores, que as entidades sindicais possuem ampla legitimidade para a postulação em juízo, como substitutos processuais dos integrantes da categoria que representam, tanto na defesa dos direitos coletivos em sentido amplo, quanto na defesa dos direitos individuais heterogêneos.
A CONVENÇÃO 190 DA OIT E SEU POTENCIAL EMANCIPATÓRIO
Authors: Cruz Alexandre Corrêa da 
Published: November 2024

A Convenção nº 190 da OIT (ORGANIZAÇÃO, 2019a), que versa sobre o combate ao assédio moral e sexual no mundo do trabalho, embora também tenha a finalidade de atender a Agenda 2030 da ONU para o desenvolvimento sustentável, ainda é muito desconhecida pelos juslaboralistas brasileiros e pelo ambiente jurídico em geral. O objetivo do artigo é proceder a uma análise jurídica panorâmica da norma convencional, destacando os seus aspectos emancipatórios, considerados assim aqueles indutores à transformação da realidade atual para um meio ambiente laboral livre de assédio ou discriminação. E, dessa forma, ao dar maior visibilidade ao tema, o artigo também almeja estimular estudos a respeito do combate ao assédio, inclusive acerca da possibilidade de internalização da norma cosmopolita no ordenamento jurídico interno. Quanto à metodologia, o tipo de pesquisa, no que concerne à sua natureza, é qualitativo e teórico, sendo que, em relação aos objetivos, é preponderantemente explicativo e exploratório, constituindo-se, quanto ao seu objeto, em uma pesquisa bibliográfica-documental.
Pretreating Mesenchymal Stem Cells with Cancer Conditioned‐Media or Proinflammatory Cytokines Changes the Tumor and Immune Targeting by Nanoghosts Derived from these Cells
Authors: Lupu‐Haber Yael , Bronshtein Tomer , Shalom‐Luxenburg Hagit , D'Atri Domenico , Oieni Jacopo , Kaneti Limor , Shagan Alona , Hamias Shani , Amram Liat , Kaneti Galoz , Cohen Anavy Noa , Machluf Marcelle 
Published: April 2019

AbstractNanoghosts (NGs) are nanovesicles reconstructed from the cytoplasmic membranes of mesenchymal stem cells (MSCs). By retaining MSC membranes, the NGs retain the ability of these cells to home in on multiple tumors, laying the foundations, thereby, for the development of a targeted drug delivery platform. The susceptibility of MSCs to functional changes, following their exposure to cytokines or cancer‐derived conditioned‐media (CM), presents the opportunity to modify the NGs by conditioning their source cells. This opportunity is investigated by comparing the membrane protein composition and the tumor uptake of NGs derived from naïve MSCs (N‐NG) against conditioned NGs made from MSCs pre‐treated with conditioned‐media (CM‐NG) or with a mix of the proinflammatory cytokines TNF‐α and IL‐1β (Cyto‐NG). CM‐NGs are found to be more targeted towards immune cells than Cyto‐ or N‐NGs, while Cyto‐NGs are the most tumor‐targeted ones, with similar immune‐targeting capacity as N‐NGs but with a higher affinity towards endothelial cells. Proteomic variations were wider in the CM‐NGs, with exceptionally higher levels of ICAM‐1 compared to N‐ and Cyto‐NGs. From a translational point of view, the data show that the tumor‐targeting ability of the NGs, and possibly that of other MSC‐derived extracellular vesicles, can be enhanced by simple conditioning of their source cells.
Impacts of weather, work rate, hydration, and clothing in heat‐related illness in California farmworkers
Authors: Vega‐Arroyo Alondra J. , Mitchell Diane C. , Castro Javier R. , Armitage Tracey L. , Tancredi Daniel J. , Bennett Deborah H. , Schenker Marc B. 
Published: April 2019

AbstractBackgroundThe primary aim of this study was to investigate the effects of work rate, hydration status, and clothing on core body temperature (CBT) on California farmworkers.MethodsTwo hundred and eighty‐seven farmworkers were recruited in Summer 2015, with 259 participants having sufficient data for analysis. We collected CBT, ambient temperature, work rate, body weight loss, and clothing worn by each participant throughout the work day and demographic data from a questionnaire.ResultsMultiple regression with CBT as the outcome was used to determine the adjusted associations between CBT, environmental heat load, and worker characteristics. The multivariate regression model showed statistically significant associations of CBT with work rate (β = .006, 95% CI [0.004, 0.009]) and wet‐bulb globe temperature (β = .03, 95% CI [0.017, 0.05]).ConclusionResults suggest that among our population workload is the primary modifiable risk factor for heat‐related illness. As expected, the ambient temperature was also associated with higher risk.
Säurefluoride in der Übergangsmetallkatalyse: Balance von Stabilität und Reaktivität
Authors: Blanchard Nicolas , Bizet Vincent 
Published: April 2019

AbstractMehrere aktuelle Studien befassen sich mit der einzigartigen Reaktivität von Säurefluoriden als exzellente Elektrophile in der Übergangsmetallkatalyse. Diese Spezies gehen eine oxidative Addition des Metalls in die C‐F‐Bindung ein, anschließend kann das CO entweder erhalten bleiben oder freigesetzt werden, was durch die Einstellung des Katalysesystems und der Reaktionsparameter gesteuert werden kann. Säurefluoride, die aus Carbonsäuren abgeleitet werden können, zeichnen sich durch eine gute Stabilität und hohe Reaktivität in einer großen Auswahl an Funktionalisierungen mit Nukleophilen aus. Sie bieten damit eine interessante Alternative zu den zugrundeliegenden Carbonsäurederivaten (Säurechloride, Ester, Amide, Säuren oder Aldehyde).
Acid Fluorides in Transition‐Metal Catalysis: A Good Balance between Stability and Reactivity
Authors: Blanchard Nicolas , Bizet Vincent 
Published: April 2019

AbstractSeveral recent reports outlined the singular reactivity of acid fluorides as excellent electrophiles in transition‐metal catalysis. These species undergo oxidative addition of the metal into the C−F bond; then, retention or release of the CO moiety can occur and be controlled by tuning the catalytic system and the reaction parameters. Acid fluorides, which can be derived from carboxylic acids, show good stability and high reactivity in a wide range of possible functionalizations with nucleophiles. Their use provides an interesting alternative to that of the parent carboxylic acid derivatives (acid chlorides, esters, amides, acids, or aldehydes).
Fabrication of superhydrophobic polylactide films with ultraviolet‐shielding properties
Authors: Seong Ki Woong , Ryu Yeon Sung , Kim Ick‐Soo , Kim Seong Hun 
Published: April 2019

ABSTRACTZnO is a useful material with stable physical and chemical properties for introducing surface roughness and UV‐blocking properties. However, to inhibit ZnO particles’ photocatalytic degradation of peripheral organic materials, we conducted layer‐by‐layer (LbL) deposition with poly(sodium 4‐styrenesulfonate) and poly(diallyl dimethyl ammonium chloride) to fabricate ZnO particles with an SiO2 shell with tetraethyl orthosilicate. Polylactide (PLA) films were prepared by compression molding and treated with a weak alkali solution for 0.5, 1.0, 1.5, and 2.0 h to induce hydroxyl and carboxyl groups. The LbL deposition of polyelectrolytes on the PLA film was performed to induce electrical interactions between the PLA films and ZnO composite particles. ZnO composite particles were deposited onto the surface of the PLA films with dip coating, and a stable superhydrophobic surface was developed after hexadecyl trimethoxysilane treatment via a reduction in the surface energy. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 47760.
Hydrolysis and thermal stability of partially hydrolyzed polyacrylamide in high‐salinity environments
Authors: Oliveira Priscila F. , Costa Josane A. , Oliveira Luis Fernando S. , Mota Letícia S. , de Oliveira Leonardo A. , Mansur Claudia R. E. 
Published: April 2019

ABSTRACTPartially hydrolyzed polyacrylamide (HPAM) is the water‐soluble polymer most often used in flooding applications in the petroleum industry. However, in aqueous solutions at high temperatures, HPAM undergoes hydrolysis of the lateral amide groups, and the presence of salts in the solution can lead to precipitation of this polymer. Therefore, a method was developed to monitor the thermal stability of HPAM solutions in different saline environments and varying temperatures. The proposed test method involved measurements of intrinsic viscosity as a function of time and determination of the degree of hydrolysis of the HPAM by elemental analysis. The results obtained indicated that the presence of divalent cations (Ca+2 and Mg+2) negatively influenced the intrinsic viscosity of the solutions and in some systems led to precocious precipitation of the polymer in environments with higher concentrations of these cations. The hydrolysis reaction of the amide groups to the acrylate groups of the HPAM chain was significantly affected by rising temperature: at 50 °C, hydrolysis occurred, but not as significantly as at 70, 85, 90, and 95 °C. Hydrolysis up to 84% was observed for solutions processed at 90 °C. The results also indicated limits of hardness for the brine at some temperatures: 1353 ppm for 95 °C and 2867 ppm for 70 °C. For brine containing 13,610 ppm or more of divalent cations, hydrolysis and precipitation of the polymer were not observed at 50 °C. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 47793.
Hierarchically Porous Carbons Derived from Metal–Organic Framework/Chitosan Composites for High‐Performance Supercapacitors
Authors: Zhong Shan , Kitta Mitsunori , Xu Qiang 
Published: April 2019

AbstractHierarchically porous carbon materials with high surface areas are promising candidates for energy storage and conversion. Herein, the facile synthesis of hierarchically porous carbons through the calcination of metal–organic framework (MOF)/chitosan composites is reported. The effects of the chitosan (CS) additive on the pore structure of the resultant carbons are discussed. The corresponding MOF/chitosan precursors could be readily converted into hierarchically porous carbons (NPC‐V, V=1, 2, 4, and 6) with much higher ratios of meso‐/macropore volume to micropore volume (Vmeso‐macro/Vmicro). The derived carbon NPC‐2 with the high ratio of Vmeso‐macro/Vmicro=1.47 demonstrates a high specific surface area of 2375 m2 g−1, and a high pore volume of 2.49 cm3 g−1, as well as a high graphitization degree, in comparison to its counterpart (NPC) without chitosan addition. These excellent features are favorable for rapid ion diffusion/transport, endowing NPC‐2 with enhanced electrochemical behavior as supercapacitor electrodes in a symmetric electrode system, corresponding to a high specific capacitance of 199.9 F g−1 in the aqueous electrolyte and good rate capability. Good cycling stability is also observed after 10 000 cycles.
Experiment and simulation on kinetic resolution of (R,S)‐2‐chloromandelic acid by enzymatic transesterification
Authors: Yuan Xin , Kang Shuangjian , Zhang Panliang , Xu Weifeng , Tang Kewen 
Published: April 2019

AbstractOptically pure 2‐chloromandelic acid (ClMA) is a very important chiral drug intermediate for synthesis of (S)‐clopidogrel, belonging to the platelet aggregation inhibitor. Enantioselective resolution of (R,S)‐2‐chloromandelic acid was carried out in organic solvent through irreversible transesterification catalyzed by lipase AK with vinyl acetate acting as the acyl donor. Effects of various conditions on enantioselectivity and activity of lipase were investigated, including organic solvents, temperature, water content, substrate ratio, enzyme loading, and reaction time. Based on homogeneous reaction and Ping‐Pong bi‐bi mechanism, a quantitative model was constructed to simulate and optimize the reaction process. Under the optimal conditions, excellent results were obtained with high conversion of (R)‐2‐ClMA (c
R, ≥98.85%) and large enantiomeric excess of substrate (ee
s, ≥98.15%). There is a good agreement between predicted values and experiment data, which indicates that the established method is a powerful tool for optimization of the enantioselective transesterification process for enantiomers separation.