bluuebunny/crossref_metadata_2025_split huggingface dataset:
Randomized, Phase III Trial of Mixed Formulation of Fosrolapitant and Palonosetron (HR20013) in Preventing Cisplatin-Based Highly Emetogenic Chemotherapy-Induced Nausea and Vomiting: PROFIT
Authors: Zhou Huaqiang , Zhao Yuanyuan , Zhang Mingjun , Yao Jun , Leng Shuang , Li Xiumin , Lin Li , Chen Jinping , Zhang Songnan , Qin Xia , Qin Zhiquan , Yi Tienan , Wang Ruoyu , Li Xiang , Yu Yan , Wang Zhenghua , Zheng Qinhong , Mei Jiazhuan , Zang Aimin , Li Na , Cao Fengjun , Cao Ke , Li Weiwei , Lu Yanda , Lin Dang , Zhou Yan , Yang Runxiang , Fang Wenfeng , Zhou Ningning , Yang Yunpeng , Zhang Yaxiong , Chen Gang , Zhou Ting , Yang Xue , Wang Huan , Wang Yujiao , Huang Yan , Zhang Li 
Published: December 2024

PURPOSE
Mixed formulation of fosrolapitant and palonosetron (PALO), HR20013, is a novel fixed-dose intravenous antiemetic combination that could simultaneously antagonize neurokinin-1 and 5-hydroxytryptamine-3 receptors. This study was designed to evaluate the efficacy and safety of HR20013 plus dexamethasone (DEX) versus fosaprepitant (FAPR) plus PALO + DEX for preventing chemotherapy-induced nausea and vomiting (CINV) in patients receiving highly emetogenic chemotherapy (HEC).

METHODS
This is a noninferiority study. Chemotherapy-naïve patients were randomly assigned 1:1 to receive HR20013 (day 1) or FAPR + PALO (day 1) before each cycle of cisplatin-based HEC (two cycles in total), together with oral DEX (day 1-4). The primary end point was overall (0-120 hours) complete response (CR; no vomiting/no rescue therapy) rate in cycle 1. The key secondary end point was CR rate at the beyond delayed phase (120-168 hours) in cycle 1.

RESULTS

Three hundred seventy-three patients were enrolled to receive HR20013 + DEX and 377 to FAPR + PALO + DEX. The overall CR rate in cycle 1 was 77.7% for HR20013 + DEX and 78.2% for FAPR + PALO + DEX (difference = –0.9% [95% CI, –6.7 to 5.0]; one-sided
P
< .01), demonstrating that HR20013 + DEX was noninferior to FAPR + PALO + DEX. The superiority of HR20013 + DEX over FAPR + PALO + DEX in CR rate at the beyond delayed phase in cycle 1 was not met (90.3%
v
86.5%; two-sided
P
= .11). In cycle 2, HR20013 + DEX showed greater proportions of patients reporting no impact on daily life at the delayed (24-120 hours) and beyond delayed phases compared with FAPR + PALO + DEX. The incidences of treatment-related adverse events were 35.7% during cycle 1 and 42.1% during entire study for HR20013 + DEX, versus 38.2% and 44.0% for FAPR + PALO + DEX.

CONCLUSION
HR20013 + DEX was noninferior to FAPR + PALO + DEX for preventing HEC-CINV and well tolerated, with the potential to reduce the impact of CINV on daily life.
Racial and Ethnic Disparities in Failure-to-Rescue After Postoperative Sepsis After Noncardiac Surgery
Authors: Laserna Andres , van Wijngaarden Edwin , Sun Eric C. , Li Yue , Nates Joseph L. , Glance Laurent G. 
Published: December 2024

BACKGROUND:
Sepsis disproportionately affects marginalized communities. This study aims to evaluate racial and ethnic disparities in failure-to-rescue (FTR) after postoperative sepsis.

METHODS:
This cross-sectional study used data from the American College of Surgeons National Surgical Quality Improvement Program for patients who underwent inpatient noncardiac surgery between 2018 and 2021. Patients were categorized as non-Hispanic White (hereafter, White), non-Hispanic Black (hereafter, Black), Asian, and Hispanic individuals. The association between (1) FTR after sepsis and (2) FTR after septic shock and race and ethnicity was evaluated using multivariable logistic regression. Failure-to-rescue was defined as 30-day mortality among patients who developed postoperative sepsis or postoperative septic shock.

RESULTS:
Among the 1388,977 patients (mean [SD] age 60.5 [16]); 783,056 (56.4%) were female, 1017,875 (73%) were White, 171,774 (12%) were Black, 138,457 (10%) were Hispanic, and 60,871 (4%) were Asian. Compared to White individuals, Black (adjusted odds ratio [aOR], 1.29; 95% CI, 1.23–1.35, P < .001) and Hispanic individuals (aOR, 1.15; 95% CI, 1.09–1.21, P < .001) were more likely to develop sepsis; Black individuals were more likely to develop septic shock (aOR, 1.28; 95% CI, 1.21–1.36; P < .001), and Asians were less likely to develop septic shock (aOR 0.84; 95% CI, 0.75–0.93, P = .002). Black individuals experienced lower rates of FTR after sepsis [Black: (aOR, 0.71; 95% CI, 0.54—0.94; P = .017), while Black (aOR, 0.93; 95% CI, 0.80–1.08; P = .35)], Hispanic (aOR, 0.87; 95% CI, 0.72–1.06; P = .16) and Asian Individuals (aOR, 1.06; 95% CI, 0.8–1.37; P = .67) experienced similar rates of FTR after septic shock compared to White individuals.

CONCLUSIONS:
Black and Hispanic individuals experienced higher rates of postoperative sepsis but did not experience higher rates of failure-to-rescue. Reducing inequity in surgical care should focus on efforts to prevent postoperative sepsis.
Bem-estar espiritual, satisfação com a vida e sintomas psicopatológicos em mulheres grávidas: estudo transversal
Authors: Martiniano Eli Carlos , Silva Natácia Élem Felix , Quirino Glauberto da Silva 
Published: December 2024

Objetivo: analisar a correlação do nível de bem-estar espiritual e satisfação com a vida com a presença de sintomas psicopatológicos em mulheres grávidas. Método: estudo transversal desenvolvido com 307 mulheres grávidas de Juazeiro do Norte, Ceará, Brasil. A coleta de dados foi realizada entre janeiro e outubro de 2019, com aplicação dos instrumentos Spiritual Health and Life-Orientation Measure, Brief Multidimensional Life Satisfaction Scale e Inventário Breve de Sintomas. Os dados foram analisados utilizando estatística descritiva e inferencial, com teste de correlação de Pearson, respeitando nível de significância de p<0,05. Resultados: o bem-estar espiritual nas dimensões ideal (-0,501) e real (-0,496) apresentaram moderada correlação negativa diante da presença de sintomas psicopatológicos (p<0,01). Houve moderada correlação negativa (-0,664) entre a satisfação com a vida e presença de sintomas psicopatológicos (p<0,01). Conclusão: a presença de sintomas psicopatológicos em mulheres grávidas correlaciona-se à diminuição do bem-estar espiritual e satisfação com a vida.
Spiritual care in Portuguese palliative care settings: a cross-sectional study
Authors: dos Santos Rita Sampaio , Domingues Tiago , Capelas Manuel Luís , Caldeira Sílvia 
Published: December 2024

Background: Spirituality is a core dimension of palliative care. However, Portuguese palliative care teams do not have many spiritual care resources. Methods: Cross-sectional and observational survey studies were used to characterise spiritual care resources in Portuguese palliative care teams based on a non-probabilistic convenience sampling. An electronic questionnaire was used for data collection. Results: A total of 150 responses were obtained. In 68.7% of the teams, there was no specific professional dedicated to spiritual care, although 68% of the participants considered that a spiritual assessment or intervention was a part of their role; 47.3% considered that their colleagues were reasonably prepared to develop a spiritual assessment or follow-up; for a patient, and 54.7% were considered to be reasonably involved. However, 50.0% did not consider themseleves to be competent at providing spiritual care. Most referred to not using any specific assessment tool or document (67.3%); 49.3% dedicated less than 10% of their time to specific education or training about spirituality. Conclusion: This study involved different professionals from multidisciplinary teams. Most recognised the importance of attending to the patient's spirituality and spiritual care. Results suggest that there is a need for specific training, resources and techniques to meet a patient's spiritual care needs at the end of life. This need may be similar in all teams, not just palliative care teams, to facilitate comparing indicators and promote the implementation of holistic care in palliative care.
“…but I know something’s not right here”: Exploring the diagnosis and disclosure experiences of persons living with ALS
Authors: Foldvari Kathleen M. , Stolee Paul , Neiterman Elena , Boscart Veronique , Tong Catherine 
Published: December 2024

Background
Amyotrophic Lateral Sclerosis (ALS), an incurable motor neuron disease, primarily affects those between the ages of 60–79, and has an approximate post-diagnosis life-expectancy of only two to five years. The condition has an unpredictable but ultimately terminal trajectory that poses challenges for patients, caregivers and healthcare providers. While the diagnosis and disclosure are critical periods for intervention and support, knowledge regarding the relational, communicational and psychodynamic forces that occur within the process of diagnostic disclosure is relatively limited.

Objectives
The purpose of this study was to explore the experiences of persons living with ALS in the diagnosis and disclosure of the condition, with the support of their caregivers.

Methods
We conducted a focus group and in-depth individual interviews with people living with ALS (n = 9), and caregivers (n = 9). The interviews were transcribed, cleaned, and anonymized, and then entered into NVivo 11 for thematic analysis.

Results
Participants discussed the diagnostic process, including inklings and subtle changes prior to diagnosis, attempts at self-diagnosis, and the lengthy assessment process. Time was also a consideration in the diagnostic disclosure process, in which participants shared how the disclosure was the product of longstanding conversations with their care providers. It was described as rarely a shock to finally have confirmation. Participants shared their information seeking strategies and needs for a diagnosis that, for them, typically came with insufficient information on the disease, prognosis, and next steps.

Significance
This project serves as a step in bridging the relevant gaps in our knowledge and understanding towards improved person-centered care practices in the diagnosis and disclosure of ALS.
Introduction of electronic death notification in Norway—Impact on diabetes mortality registration
Authors: Eng Hanna M. , Sveen Kari Anne , Fagerås Stephanie Jebsen , Strøm Marianne Sørlie , Diep Lien My , Juliusson Petur Benedikt , Alfsen G. Cecilie 
Published: December 2024

Introduction
We studied changes in death statistics by deaths from diabetes mellitus (DM) after introduction of mandatory online death certificate (DC) submission in Norway.

Materials and methods
Information on deaths with DM mentioned in the DCs from year 2017 (DCs submitted on paper) to 2022 (DCs submitted online) was collected from the Norwegian Cause of Death Registry (NCoDR), Sex, age, year of death and type of DC (paper (pDC) vs electronic (eDC)) was registered. In DCs with DM as underlying cause of death (UCOD), all codes (International classification of diseases, 10th revision (ICD-10)), their original position in the DC and place of death were collected. DM was classified as type-1, type-2 and other. Differences between 2017 and 2022 according to use of unspecified DM diagnoses, number of changed diagnoses after automated processing, correct positioning of UCOD in DC, total number of diagnoses, and use of ill- defined diagnoses were analyzed. Generalized linear models for binomial outcome with log link were used to fit mortality data and test differences between electronic and paper registration systems, two-sample t-test and linear regressions for analysis of differences in number of diagnoses.

Results
229 807 deaths were registered, including 3 864 DM deaths. Online DC submission increased from 0 in 2017 to 95% in 2022. In 2022, DCs with DM as UCOD showed significant less use of unspecified diabetes diagnoses (Relative risk,RR: 0.18, 95% confidence interval (CI): 0.14–0.22), reduced need for change of diagnoses after automated processing (RR: 0.52, CI: 0.46–0.59), reduced number of diagnoses (CI: -0.7 to -0.38), and less use of ill-defined diagnoses (RR: 0.83, CI: 0.71–0.97).

Conclusions
The introduction of online cause of death submission in Norway improved the quality of registration of deaths from diabetes.
Perceived clinical competence and its related factors among registered nurses employed at selected outpatient clinics in Egypt
Authors: Mohamed Rasha A. , Alharbi Mohammed Fayez J. , Aloufi Rahmah , Abraham Nisha , Taref Nagwa Nabeh , Bauomy Eman Samy , Alkalash Safa H. , Marzouk Marzouk M. , Almowafy Abeer A. 
Published: December 2024

Introduction
Nurses’ clinical competence is a significant concern in all healthcare settings due to the necessity of delivering high-quality patient care. Understanding and addressing the factors related to competence are crucial for promoting nurses’ clinical competence and ultimately improving patient outcomes. Producing and maintaining a skilled nursing workforce is essential to protect communities.

Aim
This study aimed to assess the level of self-evaluated clinical competence and its correlation with demographic and occupational variables among registered nurses employed at selected outpatient clinics in Egypt.

Materials and methods
The study utilized a descriptive cross-sectional design with a self-administered, two-part questionnaire that assessed participants’ demographic and occupational variables as well as perceived clinical competence in various healthcare settings. It took place at outpatient clinics of two governmental hospitals and five primary healthcare centers in Mansoura City, Egypt between January, and June 2023. A purposive sample of 450 nurses took part in this study.

Results
The average score of nurses’ clinical competence was 155.3±7.2 out of 230, indicating a “moderate level”. In terms of professional behaviors and general performance, the average score for clinical competence was 48.4±3.6 and 40.7±4.1 respectively. Additionally, the average score for clinical competence regarding core and advanced nursing skills were 43.4±3.0 and 22.8±1.5 respectively. Among the domains of clinical competence, the highest average score was associated with “professional behaviors” as it forms the backbone of nursing practice. There was a highly significant relationship between the average score of clinical competence and the participant’s age, sex, level of education, and years of clinical work experience (P<0.001).

Conclusion
Nurses perceived their level of clinical competence as moderate. To enhance nurses’ clinical competence, future studies and interventions should focus on promoting supportive work environments, providing ongoing education and training in advanced nursing skills, and the fostering development of critical thinking skills in nurses.

Recommendations
Healthcare organizations should implement educational interventions to enhance nurses’ clinical competence. These interventions should include continuous professional development opportunities, mentorship programs, inclusive training initiatives, and structured feedback mechanisms. These measures will help nurses stay up-to-date with the latest practices and technologies, create a supportive learning atmosphere, and address the unique needs and challenges faced by nurses of different genders and specialties.
Determinants of mortality among preterm neonates admitted at Wolaita Sodo University Comprehensive Specialized Hospital, southern Ethiopia: An unmatched case-control study
Authors: Bogale Alemu , Borko Ushula Deboch , Abreha Solomon , Balta Bargude 
Published: December 2024

Background
Preterm birth accounts about 1 million neonatal deaths worldwide and the second causes of both neonatal and under five-child mortality. From this preterm is the second leading cause of death and is steadily increased in low-income countries. In Ethiopia, Preterm neonatal death is the first and fourth cause of newborn and under-5 deaths, respectively. Although the general newborn mortality rate in the research area was 27 per 1000 neonates, but the preterm neonatal mortality rate and determinants were not previously well recognized. This study aimed to identify the Determinants of preterm neonatal mortality admitted to WSUCSH, with some variations from other studies carried out in in terms of the environment, hospital setting and the inclusion of additional factors.

Methods
An institution-based, unmatched case-control study was conducted from June 1–15, 2023 on preterm neonates who admitted to Wolaita Sodo University Comprehensive Specialized Hospital from July 1, 2020, to June 30, 2022. A total of 690 with 1:2 ratio (230 cases and 460 controls respectively) preterm neonate medical charts were used for data extraction using a pre-established tool. Data were checked for completeness and consistency, entered using Epi-Data V.4.6, and transported to SPSS version 26 for analysis. Multivariate logistic regression analysis was performed to identify the independent determinants of preterm neonate mortality at a p value of < 0.05 along with a 95% confidence interval (CI). Finally, the model fitness of the study was assessed using the Hosmer and Lemshow model fitness test.

Results
The preterm neonatal death rate was 10.9%. Hypothermia (AOR = 1.66, 95% CI:1.03–2.67), Sepsis (AOR = 3.35, 95% CI: 1.25 8.96), hypoglycemia (AOR = 2.85, 95% CI:1.09–7.44), Respiratory distress syndrome(RDS) (AOR = 7.21 95% CI:2.18–23.92), necrotizing enter colitis (AOR = 7.92, 95% CI:2.96–21.12) and neonates who stayed at hospital less than 7 days (AOR = 7.36, 95% CI:2.82,19.22) were predictors of preterm mortality.

Conclusion and recommendation
Preterm neonatal mortality in this setting is mainly related to sepsis, respiratory distress syndrome (RDS), necrotizing enter colitis (NEC), hypoglycemia, hypothermia, and brief hospital stay. Thus, it would be preferable to offer appropriate prevention measures and extra care for neonates who have those factors.
Subjetividades Contemporâneas, Corpo e Tempo: O que quer de nós uma Clínica Social?
Authors: Hoffmann Catharina 
Published: December 2024

Esse artigo apresenta a clínica social como objeto de debate dentro da perspectiva de que o corpo é seu campo de intervenção. Através de Revisão de Literatura, partimos da abordagem reichiana, abrindo-nos ao diálogo político com Michel Foucault, Gilles Deleuze e Félix Guattari sobre o desejo no campo social. Em seguida, apresentamos algumas narrativas sobre o corpo ao longo da história até os dias atuais para, então, num plano de imanência da clínica, trazer como resultados as contribuições de Gregório Baremblitt numa inusitada composição com as adaptações metodológicas apresentadas por Hector Fiorini através da Psicoterapia Breve. Arrematamos a discussão incluindo o fator tempo na clínica e a adequação dos corpos aos processos de aceleração e descartabilidade na contemporaneidade. Ao final, propomos um olhar para a Análise Bioenergética de Alexander Lowen como uma abordagem de resistência para viver o tempo do fluxo e das intensidades.
Comparison of Open Source SDN Controllers and Cloud Platforms in Terms of Performance, Stability, and Infrastructure Flexibility
Authors: Mycek Andrzej 
Published: December 2024

The IT industry is advancing rapidly, with virtually every branch of modern computing experiencing swift development. Concepts such as Cloud Computing and Artificial Intelligence no longer surprise anyone. Recently, Software Defined Networks (SDN) have been gaining significant popularity. This innovative approach to computer networks allows for greater flexibility and is, therefore, much more well-known in the world of cloud computing than in traditional network implementations. This paper introduces the concept of SDN and Network Functions Virtualization (NFV) and outlines all the challenges and security issues associated with the cloud environment. The dynamic nature of the IT landscape requires constant adaptation to emerging technologies, and SDN represents a noteworthy evolution in the realm of computer networking. Platforms such as SDN and open-source tools enabling the creation of private cloud environments such as OpenStack or OpenNebula were compared. At the same time, aspects like security, network performance, flexibility, and scalability were analyzed. Based on the prior analysis, a comprehensive cloud environment was built using the OpenStack solution and SDN - OpenDaylight was deployed. Additional tests conducted on the OpenStack cloud, both with and without SDN, demonstrated the superiority of SDN implementation in the cloud.
Wszyscy jesteśmy zdalnymi uczestnikami wojny. Analizy Jeana Baudrillarda jako podstawa wytwarzania humanistycznego oporu wobec konfliktów militarnych
Authors: Ilnicki Rafał 
Published: December 2024

Jean Baudrillard presents provocative thesis that not only soldiers are participants in war but also people watching television are hostages to the ongoing military conflicts. The article will adress the genesis of this thesis based on the Baudrillard’s idea of virtuality of war that prevents from real war of happing, while at the same time obviously real war is taking place. This paradoxical situation will be the basis for both acknowledgment and criticism of Baudrillard’s interpretation of war. The main point of criticism is that Baudrillard erases people and at the same time is providing sophisticated analysis of people involved at different stateges of military conflicts. This leads to a lot of inconsistencies in Baudrillards thought. At the same time time Baudrillard refers to the humanistic goal of uncovering the real meaning of war behind what media create as illusion but this intelelectual perspective lacks in acknowledging his own position as an author and the freedom to think and act of viewers-hostages of media spectacle of war. In article there will presented a way of overcoming this cricis of passive remote viewer toward engaged humanistic approach which is available to people but on the condidition that they will want it to be important perspective in their lives.
Eine Nachlese zu Oluf Krückmann, Neubabylonische Rechts- und Verwaltungstexte (TMH 2/3), Teil 1
Authors: Hackl Johannes 
Published: December 2024

Abstract
The article provides an overview of the history of the Hilprecht Collection at the Friedrich Schiller University Jena, with a particular focus on the period after 1926, i.e., the year when Hilprecht’s objects arrived in Jena. Special attention is given to the Neo-Babylonian texts of the collection, most of which were published in copy by Oluf Krückmann in TMH 2/3 in 1933.
Der Familienbrief PBS 1/2, 21
Authors: Zimmermann Lynn-Salammbô 
Published: December 2024

Abstract
The Kassite family letter PBS 1/2, 21 concerns a court procedure in which a female sender is involved. In this article I analyse the language and style of PBS 1/2, 21 with the help of “Speech Act Theory”, which shows that the female sender Rīšat-[...] had limited authority and justified her actions with elaborate quotations of men’s orders, thereby transferring responsibility for her actions to the men she quoted. Only four out of 331 Kassite letters from Nippur were sent by women. The other three Kassite letters from a female sender indicate that a woman named Inbi-ajjari held an influential position in the Nippurean administration and was involved in governance processes. Rīšat-[...]’s letter differs considerably from Inbi-ajjari’s letters. While Rīšat-[...]’s letter illuminates a woman’s societal role within a family, Inbi-ajjari’s bēlu letters illustrate the power of influential women outside their family structures.