bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mutation in the SLC29A3 Gene in an Egyptian Patient with H Syndrome: A Case Report and Review of Literature
Authors: El-Bassyouni Hala T. , Thomas Manal M. , Tosson Angie M.S. 
Published: October 2019

AbstractHistiocytosis-lymphadenopathy plus syndrome (H syndrome) is caused by mutations in the SLC29A3 gene that result in histiocytic infiltration of numerous organs. Patients suffering from this disorder can be easily mistaken for similar conditions such as Muckle–Wells syndrome. We present a 9.5-year-old boy, who is the offspring of a consanguineous marriage. He suffered from sensorineural hearing loss, dark hyperpigmented indurated dry areas on the medial thighs sparing the knees with hypertrichosis on the affected areas, and areas of hypopigmentation on the abdomen. The patient displayed mild dysmorphism including frontal bossing, synophrys, bilateral proptosis (with normal thyroid function), thick eyebrows, flat nose, long philtrum, and pectus excavatum. Formal intelligence testing showed that he was a slow learner. Laboratory findings included elevated serum amyloid-A, erythrocyte sedimentation rate, and total proteins in urine tests. Complete blood count showed mild microcytic hypochromic anemia. The molecular analysis was crucial to confirm the provisional clinical diagnosis. H syndrome is a rare autoinflammatory syndrome with pleiotropic manifestations that affect many organs and can be mistaken for other conditions. Our patient's description may expand the phenotype of H syndrome, as areas of hypopigmentation were observed on the abdomen. Molecular analysis of SLC29A3-related diseases is essential to highlight the variability and increase the awareness of H syndrome aiming for early diagnosis and proper treatment.
Anti-Factor Xa–Based Anticoagulation during Extracorporeal Membrane Oxygenation: Potential Problems and Possible Solutions
Authors: Ranucci Marco , Cotza Mauro , Isgrò Giuseppe , Carboni Giovanni , Ballotta Andrea , Baryshnikova Ekaterina ,   for the Surgical Clinical Outcome REsearch (SCORE) Group
Published: September 2019

AbstractChoices for monitoring of unfractionated heparin (UFH) anticoagulation in extracorporeal membrane oxygenation (ECMO) patients include activated clotting time, activated partial thromboplastin time, reaction times of viscoelastic tests, and anti-factor Xa activity (between 0.3 and 0.7 IU/mL). Recent studies propose the anti-factor Xa to be the gold standard for monitoring UFH anticoagulation in ECMO. However, many extraneous factors combined question the utility of anti-factor Xa as the sole method of monitoring of UFH effects in ECMO. Anti-factor Xa is a chromogenic assay, which may be biased by the frequently elevated values of bilirubin and free hemoglobin in ECMO patients. The test may alternatively underestimate UFH effects in cases of low antithrombin values. More importantly, the anti-factor Xa assay is a plasma-based test which does not take into account the role of platelets and fibrinogen in forming a stable clot. Thrombocytopenia and platelet dysfunction are common features in ECMO patients, and underestimating their role may lead to over-anticoagulation, should only anti-factor Xa guiding be used to adjust the UFH dose. Conversely, fibrinogen is an acute phase protein, and some patients may experience high levels of fibrinogen during the ECMO course. In this case, an UFH monitoring based on anti-factor Xa is insensitive to this condition, although it may potentially be associated with thrombotic complications. Finally, the generally suggested range of 0.3 to 0.7 IU/mL is a somewhat arbitrary estimate, based on the desired range for treating and preventing thrombotic events in non-ECMO patients. In conclusion, anti-factor Xa may offer useful information on the real effects of UFH only when combined with a whole blood test capable of assessing the relative contribution of platelets and fibrinogen to clot formation.
Evaluation of The Erosive Potential of Soft Drinks
Authors: Carvalho Sales-Peres Sílvia Helena de , Magalhães Ana Carolina , Andrade Moreira Machado Maria Aparecida de , Buzalaf Marília Afonso Rabelo 
Published: September 2019

ABSTRACTObjectives: This in vitro study evaluated the capability of different soft drinks (Coca-Cola® -C, Coca- Cola Light® -CL, Guaraná® -G, Pepsi Twist® -P and Sprite Light® -SL) to erode dental enamel, relating the percentage of superficial microhardness change (%SMHC) to concentrations of fluoride and phosphate, buffering capacity and pH of these drinks.Methods: The soft drinks were evaluated in respect to concentration of phosphate and fluoride spectrophotometrically using Fiske, Subarrow method and by specific electrode (Orion 9609), respectively. The pH and the buffering capacity were determined by glass electrode and by estimating of the volume of NaOH necessary to change the pH of the drink in one unit, respectively. One hundred specimens of bovine enamel were randomly assigned to 5 groups of 20 each. They were exposed to 4 cycles of demineralisation in the beverage and remineralisation in artificial saliva. The softening of enamel was evaluated by %SMHC.Results: The mean %SMHC was:C=77.27%, CL= 72.45%, SL=78.43%, G=66.65% and P=67.95%. Comparing the %SMHC promoted by 5 soft drinks, SL = C > CL > P = G (P<.05). There was not significant correlation between %SMHC and the other variables tested for the five drinks (P>>.05)Conclusions: The five soft drinks caused surface softening of enamel (erosion). In respect to the chemical variables tested, despite not statistically significant, the pH seems to have more influence on the erosive potential of these drinks. (Eur J Dent 2007;1:10-13)
Changeability of Oral Cavity Environment
Authors: Surdacka Anna , Strzykała Krystyna , Rydzewska Anna 
Published: September 2019

ABSTRACTObjectives: In dentistry, the results of in vivo studies on drugs, dental fillings or prostheses are routinely evaluated based on selected oral cavity environment parameters at specific time points. Such evaluation may be confounded by ongoing changes in the oral cavity environment induced by diet, drug use, stress and other factors. The study aimed to confirm oral cavity environment changeability.Methods: 24 healthy individuals aged 20–30 had their oral cavity environment prepared by having professional hygiene procedures performed and caries lesions filled. Baseline examination and the examination two years afterwards, evaluated clinical and laboratory parameters of oral cavity environment. Caries incidence was determined based on DMFT and DMFS values, oral cavity hygiene on Plaque Index (acc. Silness & Löe) and Hygiene Index (acc. O`Leary), and the gingival status on Gingival Index (acc. Löe & Silness) and Gingival Bleeding Index (acc. Ainamo & Bay). Saliva osmolarity, pH and concentrations of Ca2+, Pi, Na+, Cl-, total protein, albumins, F- and Sr2+ were determined.Results: The results confirmed ongoing changeability of the oral cavity environment. After 2 years of the study reduction in oral cavity hygiene parameters PLI and HI (P<0.1), and gingival indices as well as lower saliva concentration of Ca2+ (P<.001), Pi (P<.06), K+ (P<.04), Sr2+ (P<.03), Na+ (P<.1), against the baseline values, were observed. Total protein and albumin saliva concentrations were also significantly lower.Conclusion: Physiological oral cavity environment is subject to constant, individually different, changes which should be considered when analysing studies that employ oral cavity environment parameters. (Eur J Dent 2007;1:14-17)
Marginal Integrity of CAD/CAM
Fixed Partial Dentures
Authors: Rosentritt Martin , Behr Michael , Kolbeck Carola , Handel Gerhard 
Published: September 2019

ABSTRACTObjectives: Computer-aided design (CAD) and manufacturing (CAM) allows the milling of high strength zirconia fixed partial dentures (FPD), however bonding to an inert ZrO2 ceramic surface may effect the marginal integrity of the FPDs. The aim of this investigation was to evaluate the marginal adaptation of zirconia FPDs at the interfaces between zirconia, cement, and tooth.Methods: Methods: 32 3-unit FPDs were fabricated of the CAD/CAM Y-TZP zirconia (Lava, 3M Espe, Germany) according to the manufacturers’ instructions. Resin cements with corresponding primer and bonding systems were used to lute the FPDs: Compolute/EBS multi (3M Espe, Germany), Panavia F/ED (Kuraray, Japan), Variolink 2/Syntac classic (Ivoclar-Vivadent, FL) and RelyX Unicem/without treatment (3M Espe, Germany). Au-alloy FPDs (BioPontostar, Bego, Germany) were cemented with RelyX Unicem and Harvard (Harvard, Germany) as the control. Marginal adaptation was evaluated with scanning electron microscopy using replica specimen before and after artificial aging. After aging, microleakage tests were performed with fuchsine solution. The interfaces between cement-tooth and cement-FPD were examined.Results: At the interfaces (cement-tooth and cement-FPD), the systems showed a 95% or higher perfect margin before and after aging. Only Variolink2/Syntac had a marginal adaptation, lower than a 70% perfect margin. Generally, the fuchsine penetration was below 20%, only BioPontstar/Harvard and Lava/Variolink2 showed penetration results between 80% and 100%.Conclusion: The success of the adhesive cementation of zirconia FPDs depends on the cement system. Under the conditions of this study, zirconia FPDs showed good to sufficient marginal integrity in combination with Panavia/ED, Compolute/EBS and RelyX Unicem. (Eur J Dent 2007;1:25-30)
Osteosarcoma: A Case Report
Authors: Yeşilovaa Esra , Akgünlü Faruk , Dolanmazc Doğan , Yaşar Füsun , Şenere Sevgi 
Published: September 2019

ABSTRACTAlthough osteosarcoma of the head and neck is a relatively rare disease, it is a highly malignant bone tumor. Diagnosis of the tumor is important especially in early stages for improving prognosis. The patients with orofacial pain firstly prefer to go to dentists. Such kind of pain may be associated with an oral or maxillofacial cancer. The dentists must be careful for evaluating the clinical and radiologic clues. These clues determine the biopsy necessity, type and management plan. The aim of this case presentation is to emphasize the importance of dentists on diagnosis and prognosis of oral malignancies. (Eur J Dent 2007;1:60-63)
Prevalence of Malocclusion Among
Adolescents In Central Anatolia
Authors: Gelgör İbrahim Erhan , Karaman İhya Ali , Ercan Ertuğrul 
Published: September 2019

ABSTRACTObjectives: The objective of this study was to describe the prevalence of malocclusion in a population of Central Anatolian adolescents in relation to gender.Methods: The sample comprised 2329 teenagers (1125 boys and 1204 girls), aged between 12 and 17 years (mean age: 14.6 yrs). Occlusal anteroposterior relationships were assessed using the Angle classification. Other variables examined were overjet, overbite, crowding, midline diastema, posterior crossbite, and scissors bite.Results:The results showed that about 10.1% of the subjects had normal occlusions, 34.9% of the subjects had Class I malocclusions, 40.0% had Class II Division 1 malocclusions, 4.7% had Class II Division 2 malocclusions and 10.3% had Class III malocclusions. Over 53.5% had normal overbites, and 18.3%, 14.4%, 5.6%, and 8.2% had increased, reduced, edge-to-edge or anterior open bite values, respectively. Overjet relationship was normal in 58.9%, increased in 25.1%, reversed in 10.4%, and edge-to-edge in 5.6%. A posterior crossbite registered in 9.5% and scissors bite in 0.3%. Anterior crowding was present in 65.2% of the sample and midline diastema in 7.0%. No clear gender differences were noted, except for normal overbite (most frequent in girls, P>.001) and increased overbite (most frequent in boys, P>.05)Conclusions: Class II Division 1 malocclusion is the most prevalent occlusal pattern among the Central Anatolian adolescents and the high values (25.1% and 18.3%) of increased overjet and overbite were a reflection of the high prevalence of Class II malocclusion. (Eur J Dent 2007;1:125-131)
The Effect of ABO Blood Types on Periodontal Status
Authors: Demir Turgut , Tezel Adnan , Orbak Recep , Eltas Abubekir , Kara Cankat , Kavrut Fahri 
Published: September 2019

ABSTRACTObjectives: The purpose of the present study was to determine whether there was a relationship between periodontal diseases and ABO blood groups.Methods: This epidemiological study was carried out on 1351 subjects who were randomly selected from individuals referred to the Faculty of Dentistry clinics for periodontal treatment or for other reasons regarding dental health. The study based on periodontal condition, blood group, and medical history. The subjects were divided into three groups as those with gingivitis, periodontitis, and the healthy ones. The effects of blood subgroups on periodontal health, gingivitis and periodontitis were investigated separately.Results: A relatively higher percentage of A group patients was found in gingivitis group and relatively higher percentage of O group patients was found in periodontitis group. A significant relationship was also determined between Rh factor and gingivitis.Conclusions: ABO blood subgroups and Rh factor may constitute a risk factor on the development of periodontal disease. However, long-term studies are needed to make a more comprehensive assessment of the effects of ABO group on periodontal diseases. (Eur J Dent 2007;1:139-143)
Color Stability of Silicone or Acrylic
Denture Liners: An in Vitro Investigation
Authors: Ergun Gulfem , Nagas Isil Cekic 
Published: September 2019

ABSTRACTObjectives: The aim of this study was to compare the color stability of three acrylic based hard liners (Ufi gel hard, Dura-Liner II, Tokuso Rebase) and two silicone based soft liners (Ufi gel permanent, Molloplast B) by using the colorimeter.Methods: Sixty disc-shaped samples, with uniform size of 10 mm diameter and 2 mm in thickness were fabricated for each material. Thirty samples were made as control group in distilled water and the remaining thirty samples were weathered in accelerated aging chamber. Color measurements were made before and after distilled water and aging. Data were statistically analyzed using nonparametric Kruskal-Wallis and Mann-Whitney U tests.Results: Data showed that there are significant differences among materials in both after distilled water and aging treatments (P>.001). These results indicated that the most discolored liner material was Dura Liner II after aging (ΔE*=16.30) and the least discolored material was Ufi gel permanent after distilled water (ΔE*=0.41).Conclusions: Based on the results of this study, silicone based liner materials are considered to be more color stable than acrylic based liner materials. (Eur J Dent 2007;1:144-151)
Detection of Enterococcus faecalis in Necrotic Teeth Root Canals by Culture and Polymerase Chain Reaction Methods
Authors: COGULU Dilsah , UZEL Atac , ONCAG Ozant , AKSOY Semiha d , ERONAT Cemal 
Published: September 2019

ABSTRACTObjectives: The aim of this study was to investigate the presence of Enterococcus faecalis in
endodontic infections in both deciduous and permanent teeth by culture and polymerase chain
reaction (PCR) methods.Methods: A total of 145 children aged 5-13 years old were involved in this study. The presence of E. faecalis in necrotic deciduous and permanent teeth root canals was studied using culture and polymerase chain reaction methods.Results: Among 145 molar teeth, 57% (n=83) presented necrotic asymptomatic pulp tissues and were included in this study. Culture and PCR methods detected the test species in 18 and 22 of 83 teeth involved, respectively. E. faecalis was cultured from 8 (18%) of 45 necrotic deciduous teeth and from 10 (26%) of 38 necrotic permanent teeth. PCR detection identified the target species in 10 (22%) and 12 (32%) of necrotic deciduous and permanent teeth respectively. Statistically significant difference in the presence of E. faecalis in deciduous and permanent teeth was found by culture and PCR methods (P=0.03 and 0.02, respectively). The difference in the presence of E. faecalis between two different methods was not statistically significant (P>.05).Conclusions: The results of the present study confirm that both culture and PCR methods are sensitive to detect E. faecalis in root canals. (Eur J Dent 2007;1:216-221)
Progression of non-cavitated lesions in dentin through a nonsurgical approach: a preliminary 12-month clinical observation
Authors: Silva da Silveira Ana Daniela , Dutra Borges Boniek Castillo , Varela Hugo de Almeida , Lima Kenio Costa de , Assunção Pinheiro Isauremi Vieira de 
Published: October 2019

ABSTRACTObjective: Considering the minimally invasive approach to dentistry, the scientific community has focused on non-invasive treatments for caries lesions. The aim of this study was to evaluate the efficacy of a nonsurgical approach to arrest occlusal non-cavitated dentin lesions through glass ionomer sealing.Methods: In this controlled clinical trial, 51 teeth with clinically non-cavitated occlusal caries radiographically located beneath the enamel-dentine junction (radiolucent area) were selected among patients presenting a moderate to high risk of caries. The teeth were randomly divided into two groups: an experimental group receiving an application of Vidrion-R (SS White) glass ionomer and a control group not submitted to any clinical intervention. Caries progression was monitored by clinical and radiographic examination at 4-monthly intervals over a period of one year. In addition, marginal integrity of the sealant was evaluated in the experimental group.Results: Clinical examination showed no statistical difference between the groups (P=.13). On the other hand, sealed teeth presented lower caries progression when analyzed by radiographic examination (P=.004).Conclusion: A glass ionomer sealant over non-cavitated occlusal caries lesions in dentin may not be sufficiently effective in arresting their progression. (Eur J Dent 2012;6:34-42)
Efficiency of caries risk assessment in young adults using Cariogram
Authors: Celik Esra Uzer , Gokay Necmi , Ates Mustafa 
Published: October 2019

ABSTRACTObjectives: The aims of this study were to: (1) evaluate the caries risk in young adults using Cariogram and (2) compare the efficiency of Cariogram with the regression risk models created using the same variables in Cariogram by examining the actual caries progression over a 2-year period.Methods: The aims of this study were to: (1) evaluate the caries risk in young adults using Cariogram and (2) compare the efficiency of Cariogram with the regression risk models created using the same variables in Cariogram by examining the actual caries progression over a 2-year period.Results: Diet frequency, plaque amount and secretion rate were significantly associated with caries increment (P<.05). Cariogram and the regression risk models explained the caries formation at a higher rate than single-variables. However, the regression risk model developed by diet frequency, plaque amount and secretion rate explained the caries formation similar to Cariogram, while the other regression model developed by all variables used in Cariogram explained the caries formation at a higher rate than this computer program.Conclusions: Cariogram is effective and can be used for caries risk assessment instead of single variables; however, it is possible to deve
An unusual presentation of generalized aggressive periodontitis with multiple impacted supernumerary teeth
Authors: Salman Arif , Meethil Archana 
Published: October 2019

ABSTRACTAggressive periodontitis is a rare condition that progresses rapidly but affects only a small percentage of population. Most of the cases are familial. The presence of supernumerary teeth is also rather rare and often familial. Therefore, a concomitant presentation of aggressive periodontitis and supernumerary teeth in an individual has generated a great interest among clinicians. Here, we report a rare nonsyndromic case of generalized aggressive periodontitis with multiple impacted supernumerary teeth. (Eur J Dent 2012;6:335-339)
Local alliances and rivalries shape near-repeat terror activity of al-Qaeda, ISIS, and insurgents
Authors: Chuang Yao-Li , Ben-Asher Noam , D’Orsogna Maria R. 
Published: October 2019

Significance
We examine near-repeat activity patterns of al-Qaeda, ISIS, and local insurgents, whereby a first terrorist attack temporarily increases the likelihood of a second one by the same group. We observe heightened near-repeat activity for all organizations in six geographic clusters and quantify the effect to persist within 20 km and 4 to 10 weeks after the first event. Near-reaction patterns, where two distinct groups react to each other’s activities, depend on the adversarial, neutral, or collaborative relationship between parties at the local level. We find no evidence of outbidding, whereas terrorist and state activities mutually reinforce one another. Our results may be useful for counterterrorism decision making and strategic resource allocation; near-repeat patterns may offer insight into local power structures.
Laminar specific fMRI reveals directed interactions in distributed networks during language processing
Authors: Sharoh Daniel , van Mourik Tim , Bains Lauren J. , Segaert Katrien , Weber Kirsten , Hagoort Peter , Norris David G. 
Published: October 2019

Significance
Laminar resolution, functional MRI (lfMRI) is a noninvasive technique with the potential to distinguish top-down and bottom-up signal contributions on the basis of laminar specific interactions between distal regions. Hitherto, lfMRI could not be demonstrated for either whole-brain distributed networks or for complex cognitive tasks. We show that lfMRI can reveal whole-brain directed networks during word reading. We identify distinct, language-critical regions based on their association with the top-down signal stream and establish lfMRI for the noninvasive assessment of directed connectivity during task performance.
Engineering the stereoisomeric structure of seed oil to mimic human milk fat
Authors: van Erp Harrie , Bryant Fiona M. , Martin-Moreno Jose , Michaelson Louise V. , Bhutada Govindprasad , Eastmond Peter J. 
Published: October 2019

Significance
In human milk fat, saturated fatty acids are esterified to the middle position on the glycerol backbone giving the triacylglycerol molecules an unusual stereochemistry that assists nutrient absorption in the infant gut. However, the fat used in most infant formulas is derived from plants, which esterify saturated fatty acids to the outer positions. Here, we have engineered the metabolism of an oilseed plant so that it accumulates triacylglycerol with more than 70% of the saturated fatty acid palmitate in the middle position, thereby mimicking human milk fat stereoisomeric structure. Applying this technology to oilseed crops (or oleaginous microorganisms) might provide a source of human milk fat substitute for infant nutrition.
A general constitutive model for dense, fine-particle suspensions validated in many geometries
Authors: Baumgarten Aaron S. , Kamrin Ken 
Published: September 2019

Significance
Shear-thickening suspensions display peculiar phenomena, exhibiting solid-like and fluid-like behaviors at the same volume fraction. These materials have puzzled researchers since the 1930s and have seen renewed interest due to advances in computational and experimental methods as well as new infrastructural and military applications that might exploit these behaviors. We introduce a continuum model for shear-thickening suspensions, which correctly predicts realistic 3D flows including transient and inhomogeneous cases. Our approach builds the microscopic physics of particle repulsion into a framework for general fluid–grain mixtures, bridging to the fields of geomechanics and granular rheology. Using a material point method routine, we provide a robust model implementation and demonstrate the method’s broader utility for a variety of fluid-particle flow problems.