bluuebunny/crossref_metadata_2025_split huggingface dataset:
New physics implication of Higgs precision measurements
Authors: Chen Ning , Gu Jiayin , Han Tao , Li Honglei , Liu Zhen , Song Huayang , Su Shufang , Su Wei , Wu Yongcheng , Yang Jin Min 
Published: May 2019

Studying the properties of the Higgs boson can be an important window to explore the physics beyond the Standard Model (SM). In this work, we present studies on the implications of the Higgs precision measurements at future Higgs Factories. We perform a global fit to various Higgs search channels to obtain the 95% C.L. constraints on the model parameter spaces of two-Higgs Doublet Model (2HDM) and Minimal Supersymmetric Standard Model (MSSM). In the 2HDM, we analyze tree-level effects as well as one-loop contributions from the heavy Higgs bosons. The strong constraints on [Formula: see text], heavy Higgs masses and their mass splitting are complementary to direct search of the LHC as well as possible future [Formula: see text] pole precision measurements. For the MSSM, we study both the Higgs couplings and mass precisions. The constraints on the CP-odd Higgs mass [Formula: see text] and stop mass scale [Formula: see text] can be complementary to the direct search of HL-LHC. We also compare the sensitivity of various future Higgs factories, namely, Circular Electron Positron Collider (CEPC), Future Circular Collider (FCC)-ee and International Linear Collider (ILC).
Safety, Efficacy, and Biomarker Analysis of Pyrotinib in Combination with Capecitabine in HER2-Positive Metastatic Breast Cancer Patients: A Phase I Clinical Trial
Authors: Li Qiao , Guan Xiuwen , Chen Shanshan , Yi Zongbi , Lan Bo , Xing Puyuan , Fan Ying , Wang Jiayu , Luo Yang , Yuan Peng , Cai Ruigang , Zhang Pin , Li Qing , Zhong Dafang , Zhang Yifan , Zou Jianjun , Zhu Xiaoyu , Ma Fei , Xu Binghe 
Published: May 2019

Abstract

Purpose:
This phase I study assessed the safety, tolerability, MTD, pharmacokinetics, antitumor activity, and predictive biomarkers of pyrotinib, an irreversible pan-ErbB inhibitor, in combination with capecitabine in patients with HER2-positive metastatic breast cancer (MBC).

Patients and Methods:
Patients received oral pyrotinib 160 mg, 240 mg, 320 mg, or 400 mg once daily continually plus capecitabine 1,000 mg/m2 twice daily on days 1 to 14 of a 21-day cycle. Pharmacokinetic blood samples were collected on days 1 and 14. Next-generation sequencing was performed on circulating tumor DNA to probe for predictive biomarkers.

Results:
A total of 28 patients were enrolled, 22 patients were treated at the two top-level doses. Among 17 (60.7%) trastuzumab-pretreated patients, 11 received trastuzumab for metastatic disease and 6 received adjuvant trastuzumab. No dose-limited toxicity was observed. Grade 3 treatment-related adverse events (AE) occurred in 12 (42.9%) patients; anemia (14.3%) and diarrhea (10.7%) were the most common grade 3 AEs. The overall response rate (ORR) was 78.6% [95% confidence interval (CI): 59.0%–91.7%], and the clinical benefit rate was 85.7% (95% CI: 67.3%–96.0%). The median progression-free survival (PFS) was 22.1 months (95% CI: 9.0–26.2 months). ORR was 70.6% (12/17) in trastuzumab-pretreated patients and 90.9% (10/11) in trastuzumab-naïve patients. Analysis of all genetic alterations in HER2-related signaling network in baseline blood samples suggested that multiple genetic alterations were significantly associated with poorer PFS compared with none or one genetic alteration (median, 16.8 vs. 29.9 months, P = 0.006).

Conclusions:
In a population largely naïve to HER2-targeted therapy, pyrotinib in combination with capecitabine was well-tolerated and demonstrates promising antitumor activity in patients with HER2-positive MBC.
Serine/Arginine–Rich Splicing Factor 3 Modulates the Alternative Splicing of Cytoplasmic Polyadenylation Element Binding Protein 2
Authors: DeLigio James T. , Stevens Shaun C. , Nazario-Muñoz Gina S. , MacKnight H. Patrick , Doe Keli K. , Chalfant Charles E. , Park Margaret A. 
Published: May 2019

Abstract

Triple negative breast cancer (TNBC) has an unusually low 5-year survival rate linked to higher metastatic rates. Our laboratory recently delineated a role for the alternative RNA splicing (AS) of cytoplasmic polyadenylation element binding protein 2 (CPEB2), via inclusion/exclusion of exon 4, in the metastasis of TNBC. In these studies, the mechanism governing the inclusion/exclusion of exon 4 was examined. Specifically, the RNA trans-factor, SRSF3, was found to be explicitly associated with CPEB2 exon 4. A SRSF3 consensus sequence was identified in exon 4, and mutation of this sequence abolished the association of SRSF3. The expression of SRSF3 was upregulated in TNBC cells upon the acquisition of anoikis resistance correlating with a reduction in the CPEB2A/B ratio. Importantly, downregulation of SRSF3 in these cells by siRNA induced the exclusion of exon 4 in cells increasing the ratio of CPEB2A (exon 4 excluded) to CPEB2B (exon 4 included). Downregulation of SRSF3 also reversed the CPEB2A/B ratio of a wild-type CPEB2 exon 4 minigene and endogenous CPEB2 pre-mRNA, but not a mutant CPEB2 minigene with the SRSF3 RNA cis-element ablated. SRSF3 downregulation ablated the anoikis resistance of TNBC cells, which was “rescued” by ectopic expression of CPEB2B. Finally, analysis of The Cancer Genome Atlas database showed a positive relationship between SRSF3 expression and lower CPEB2A/B ratios in aggressive breast cancers.

Implications:
These findings demonstrate that SRSF3 modulates CPEB2 AS to induce the expression of the CPEB2B isoform that drives TNBC phenotypes correlating with aggressive human breast cancer.

Visual Overview:
http://mcr.aacrjournals.org/content/molcanres/17/9/1920/F1.large.jpg.
Differential Clinical Profiles, Exercise Responses, and Outcomes Associated With Existing HFpEF Definitions
Authors: Ho Jennifer E. , Zern Emily K. , Wooster Luke , Bailey Cole S. , Cunningham Thomas , Eisman Aaron S. , Hardin Kathryn M. , Zampierollo Giovanna A. , Jarolim Petr , Pappagianopoulos Paul P. , Malhotra Rajeev , Nayor Matthew , Lewis Gregory D. 
Published: May 2019

Background:
Heart failure with preserved ejection fraction (HFpEF) is common, yet there is currently no consensus on how to define HFpEF according to various society and clinical trial criteria. How clinical and hemodynamic profiles of patients vary across definitions is unclear. We sought to determine clinical characteristics, as well as physiologic and prognostic implications of applying various criteria to define HFpEF.

Methods:
We examined consecutive patients with chronic exertional dyspnea (New York Heart Association class II to IV) and ejection fraction ≥50% referred for comprehensive cardiopulmonary exercise testing with invasive hemodynamic monitoring. We applied societal and clinical trial HFpEF definitions and compared clinical profiles, exercise responses, and cardiovascular outcomes.

Results:

Of 461 patients (age 58±15 years, 62% women), 416 met American College of Cardiology/American Heart Association (ACC/AHA), 205 met European Society of Cardiology (ESC), and 55 met Heart Failure Society of America (HFSA) criteria for HFpEF. Clinical profiles and exercise capacity varied across definitions, with peak oxygen uptake of 16.2±5.2 (ACC/AHA), 14.1±4.2 (ESC), and 12.7±3.1 mL·kg
-1
·min
-1
(HFSA). A total of 243 patients had hemodynamic evidence of HFpEF (abnormal rest or exercise filling pressures), of whom 222 met ACC/AHA, 161 met ESC, and 41 met HFSA criteria. Over a mean follow-up of 3.8 years, the incidence of cardiovascular outcomes ranged from 75 (ACC/AHA) to 298 events per 1000 person-years (HFSA). Application of clinical trial definitions of HFpEF similarly resulted in distinct patient classification and prognostication.

Conclusions:
Use of different HFpEF classifications variably enriches for future cardiovascular events, but at the expense of not including up to 85% of individuals with physiologic evidence of HFpEF. Comprehensive phenotyping of patients with suspected heart failure highlights the limitations and heterogeneity of current HFpEF definitions and may help to refine HFpEF subgrouping to test therapeutic interventions.
Pulse Wave Velocities Derived From Cuff Ambulatory Pulse Wave Analysis
Authors: Schwartz Joseph E. , Feig Peter U. , Izzo Joseph L. 
Published: May 2019

Pulse wave velocity (PWV), a measure of arterial stiffness, is an independent risk factor for cardiovascular morbidity and mortality. We investigated the relationship of ambulatory brachial cuff-based oscillometric PWV (oPWV) to 2 known correlates: age and brachial systolic blood pressure (SBP). In 234 participants in the Masked Hypertension Study, we analyzed 7284 validated hourly ambulatory SBP and oPWV readings using the Mobil-O-Graph monitor, which uses a proprietary pulse wave analysis algorithm to determine oPWV. Carotid-femoral PWV (cfPWV) was also measured. Mixed linear models were developed to estimate oPWV from age and ambulatory SBP. Participants were 34% male, with mean (SD) age 52.8 (9.9) years, SBP 123.8 (18.4) mm Hg, and oPWV 7.6 (1.3) m/s and cfPWV of 7.7 (1.7) m/s. The relationship of oPWV to age and SBP is given below:
Age uniquely accounted for an estimated 75% of the total variation of oPWV, whereas SBP uniquely accounted for 20%; these findings were confirmed in an external validation dataset. Together, age and SBP accounted for 99.1% of the total variance of oPWV but (only) 40.2% of the variance of cfPWV. The correlation between oPWV and cfPWV was 0.58 but was only 0.11 after controlling for age and SBP. We conclude that the Mobil-O-Graph’s oPWV is nearly completely explained by age and SBP and its relationship to cfPWV is because of their shared associations with age and SBP. Other hemodynamic variables derived from oscillometric pulse wave analysis may be useful and deserve additional scrutiny.
Cossacks and Sturgeons: Fisheries, Colonization, and Science around the Aral Sea (1873-1906)
Authors: Pianciola Niccolò 
Published: May 2019

AbstractThe article addresses the managing of Aral Sea fisheries by the Tsarist administration, and the making of a colonial frontier inhabited by exiled Ural Cossack, Qaraqalpaq, Qazaq, Russian, and Ukrainian fishermen. By comparing the different power relations between Cossacks and the local population on the Ural River and in the Aral Sea region, it shows how they shaped fisheries management regulations and their effectiveness. It also investigates the conditions of production of scientific knowledge on the Aral Sea ecosystem and what role it played in governance decision-making. By drafting a series of fishing regulations and by examining the balance between humans and aquatic animals, scientists oriented the Tsarist government’s decisions on how to manage both the fisheries and the populations that exploited them. At the same time, members of a specific social group, the exiled Ural Cossacks, functioned as mediators between the imperial state and an ecosystem undergoing colonization.
The Grand Canal in Republican China
Authors: Ye Shirley 
Published: May 2019

AbstractSince the late imperial era, Yellow River floods have endangered the environmental equilibrium of North China, including parts of the Grand Canal. The Republican government’s response to water disasters reflected the influence of global networks and institutions of expertise. By turning to an American company for infrastructure work on the Grand Canal, Chinese government officials placed their faith in global science and finance to renew a domestic symbol of state power. The project failed; nonetheless the efforts to restore the waterways and provide relief reveal the entangled humanitarian, corporate, and educational interests of modern China’s state building and environmental management.
On-Campus Animal-Assisted Therapy Events
Authors: McArthur Alisa D. , Syrnyk Corinne 
Published: May 2019

Abstract
Post-secondary students are experiencing more stress than ever before. In an attempt to help alleviate some of this stress, animal-assisted therapy (AAT) events were held on the campus of a small liberal arts institution just prior to final exams in the Fall and Winter terms. All students were invited to mingle with dogs and handlers from a local AAT advocacy group. In Study 1, students were surveyed following the events held in the Fall and Winter and self-reported an improved mood as a result of the events as well as being extremely satisfied with the experience. Similarly, Study 2, held in the subsequent Fall, replicated the findings from Study 1. In addition, the Brief Mood Inspection Scale, administered before and after the event, found students’ mood improved on all three subscales. The implications for future research to fully assess the impact of such events on students are discussed.
The “Supplementary” Historian? Li Zhao’s Guo shi bu as Mid-Tang Political and Social Critique
Authors: Shields Anna M. 
Published: May 2019

This article examines the Tang dynasty anecdote collection Guo shi bu 國史補 (Supplement to the History of the State), compiled by Li Zhao 李肇 (?-after 827) in part as a critique of imperial government and elite social mores of the early decades of the ninth century. A quantitative analysis of topic frequency and distribution in the collection reveals Li Zhao’s techniques for depicting the corruption or political brilliance of the reigns of Tang emperors, as well as his admiration of powerful aristocratic clans, and his disdain for social climbing, perspectives that likely stemmed from his experiences as an official in Xianzong’s court and his elite family background. Understanding the organization, underlying themes, and structure of individual anecdotes of the Guo shi bu allows us to see the ways that anecdotes and “miscellaneous” histories ultimately shaped official accounts of the Tang dynasty. Cet article examine la collection d’anecdotes d’époque Tang Guo shi bu 國史補 (supplément à l’histoire de l’Etat) compilée par Li Zhao 李肇 (?-après 827), et la considère en partie comme une critique du gouvernement impérial et des mœurs des élites au début du ixe siècle. Une analyse quantitative des thèmes traités, dans leur fréquence et leur répartition au sein de l’ouvrage permet de révéler les techniques mises en œuvre par Li Zhao pour décrire la corruption ou le rayonnement politique des règnes des empereurs Tang successifs, son admiration pour les grands clans aristocratiques, et son dédain pour les parvenus et l’ascension sociale. Li hérite certainement cette vision de son expérience en tant que fonctionnaire à la cour de Xianzong ainsi que de son ascendance au sein des élites. Une telle compréhension de l’organisation du Guo shi bu, de ses thèmes sous-jacents et de la structure des anecdotes prises individuellement nous permet de mieux saisir comment les anecdotes et les miscellanées ont fini par déterminer le contenu des histoires officielles de la dynastie des Tang.
Reflections on Earth's Insights from an East Asianist
Authors: Tucker Mary Evelyn 
Published: May 2019

AbstractCallicott's Earth's Insights is a remarkable survey of resources from the world's religions for formulating a global ethics. He mentions, in particular, the rich symbolic and conceptual resources available from East Asia. This paper supports such an assertion and develops more fully the teachings of Japanese Shingon Buddhism which helped to foster a deep identity with the natural world by means of ritual. Moreover, the paper suggests that the literary and artistic resources of Japanese culture are also important sources for further exploration.
Das Ungeschehene
Authors: Iyer Arun 
Published: May 2019

Abstract
This paper aims to explicate what Heidegger means by das Ungeschehene (the un-happened), revealing the significance of this concept in providing us with a novel way of understanding and relating to the historical past. Taking recourse to ga 38, it will show that this concept has to be understood in connection with Heidegger’s very specific way of understanding what was (das Gewesene) not as that which has simply elapsed and passed away (das Vergangene) but as that which continues to abide and bear upon the present. It will clarify that the un-happened is neither the same as that which did happen nor the same as that which did not happen. Through a concrete discussion of a specific period in India’s colonial history, it will establish how the un-happened occupies a unique place between what happened and what did not happen, making it very different from a counterfactual.
Heidegger’s Reassessment of Metaphysica Specialis and the Status of Metontological Inquiry in the Late Marburg Period
Authors: Reichl Pavel 
Published: May 2019

Abstract
This article examines the development of Heidegger’s thought directly following Being and Time, a period that is significant both in its own right and in its capacity to shed light on the problems driving Heidegger’s later works. I assess Crowell’s thesis that Heidegger’s aim was to develop a metontology along the lines of a pre-critical metaphysica specialis based on a reassessment of Kant’s transcendental dialectic. I show that such a reading misrepresents the nature of Heidegger’s project in this period and argue that Heidegger was instead attempting to develop a distinctively critical metaphysics in a post-Kantian vein.
Sermons as Practical and Linguistic Performances: Insights from Theory and History
Authors: Tayob Abdulkader 
Published: May 2019

Abstract
Sermons lend themselves to ambiguous identification in the study of religions. On the one hand, they are easily recognisable practices, delivered on particular days of the week, or when special occasions or needs arise. They are usually given in clearly defined places at clearly defined times. They are given by designated or recognized individuals that vary according to the respective religious traditions. On the other hand, sermons are speech performances that may and often do vary from one occasion to the next. While prone to a certain formalism, sermon speech acts are open to variation from time to time, and from preacher to preacher. To extend the possibilities offered by sermons for reflection and analysis, I explore some of the theoretical insights suggested for sermons in ritual studies and from the history of sermons within religious traditions. There is no consensus within ritual studies, but there are some useful ideas and suggestions that cover and extend the practices and speech acts that constitute sermons. More significantly, I found the longue durée of the sermon in the Abrahamic traditions of Judaism, Christianity, and Islam to be more resourceful. The historical view of the sermon in comparable religious traditions brings forth enduring elements such as reading texts, employing rhetoric, producing effects (including affect), signifying and challenging authority, and marking time and space. More than the theoretical models for rituals from anthropology and religious studies, this historical perspective brings out the value of the practices and speech elements that constitute sermons.
Hebräischer Buchdruck zwischen Hofjuden-Mäzenatentum und christlicher Zensur Wie die Harzstadt Blankenburg nicht zum jüdischen Publikationsort wurde
Authors: Strobach Berndt 
Published: May 2019

AbstractIn a petty German principality around 1700, an influential Court Jew wants a traditional Hebrew commentary published. The printer he commissions moves shop and starts printing, not aware of severe clerical censorship. With part of the job done he has to move to another location hoping for a more liberal policy there. Within the absolutist system the episode highlights the opportunities and the limits of Court Jew's influence, as well as the prince's wavering between the prospect of profiting from a new trade and the fear of risking covert un-Christian propaganda.
Das deutsche Quäkertum in der Frühen Neuzeit Ein grundsätzlicher Beitrag zur Pietismusforschung
Authors: Bernet Claus 
Published: May 2019

AbstractQuakerism is the first Anglo-American religion that has gained ground in Germany, especially in the north, in the second half of the 17th century. Contrary to older church historiography, this was not a marginal phenomenon. Rather, stable congregations developed, as did a Europe-wide network of missionary work and a differentiated culture of polemic writings. These points of encounter allowed the Quakers to establish contact with supporters of Böhme and radical pietists while at the same time enabling an Antiquakeriana campaign against them. At the center of this study lies the question for the religious-historical positioning of Quakerism. The author argues that due to impulses of extra-ecclesiastical pietism, positions arose that transgressed Christianity's frame of reference. Therefore the reference to the early modern understanding of esoterism has proven especially useful.
The Work of Code Switching
Authors: Krasas Jackie 
Published: May 2019

Abstract
Although the term “code switching” arose in linguistic contexts, its meaning has broadened to include shifting the use of language, interactions, appearance, and the body in all areas of social life. Uncritical applications of the concept render invisible the normative nature and power dynamics along familiar dimensions of social inequality such as gender and race. “Whiteness” and “maleness” often become cast as the neutral standards against which all else is judged and are rarely revealed as the social constructions that they are. The result is the call for non-dominant groups to assimilate. In employment, we see this call for assimilation often under the guise of “soft skills,” with particular reference made to the needs of a postindustrial service-oriented labor market. Cast in terms of skill, the heightened demand for code switching in employment promises to reproduce and even intensify existing labor market inequalities along the lines of gender and race.
Power Play
Authors: Simmons K. Merinda 
Published: May 2019

Abstract
This essay examines how the rhetoric of recovery and reclamation functions in scholarly projects that aim to switch traditional or historical narrative codes. After describing the discourse on “post-blackness” as an example of how prefixes serve as problematic stabilizers in academe, I will offer a few moments in recent popular commemorative culture – especially the events that recognized desegregation at the University of Alabama – as narrative sites where the limitations of recovery work become apparent.
Theo-political Discourse and Rock ’n’ Roll in the Reagan Era
Authors: Trost Theodore Louis 
Published: May 2019

Abstract
Part of an ongoing study of religious rhetoric in politics and art, this essay identifies some of the uses to which theological language has been put in academic discourses about human relationships as they are ethically and politically constructed. It reviews the “Reagan Era” (1980–1988) in the United States through the works of certain songwriters who use theological language to critique the dominant politics of the era.