bluuebunny/crossref_metadata_2025_split huggingface dataset:
Elevated plasma triglycerides and growth rate are early indicators of reproductive status in post-spawning female steelhead trout (Oncorhynchus mykiss)
Authors: Jenkins Laura E , Pierce Andrew L , Graham Neil D , Medeiros Lea R , Hatch Douglas R , Nagler James J 
Published: June 2019

Abstract
Many iteroparous fishes spawn after skipping one or more yearly cycles, which impacts recruitment estimates used for fisheries management and conservation. The physiological mechanisms underlying the development of consecutive and skip spawning life histories in fishes are not well understood. In salmonids, lipid energy reserves and/or growth are thought to regulate the initiation of reproductive maturation during a critical period ~1 year prior to spawning. The fasting spawning migration of summer-run steelhead trout (Oncorhynchus mykiss) results in significant depletion of energy reserves during the proposed critical period for repeat spawning. To determine whether and when lipid energy reserves and growth influence repeat spawning, measures of lipid energy reserves, growth rate and reproductive development were tracked in female steelhead trout from first to second spawning as a consecutive or skip spawner in captivity. Plasma triglyceride (TG) levels and growth rate were elevated by 10 weeks after spawning in reproductive (i.e. consecutive spawning) versus non-reproductive (i.e. skip spawning) individuals. Muscle lipid (ML) levels, condition factor and plasma estradiol levels increased at later time points. The early differences in plasma TG levels and increases in growth rate are attributable to differential rates of feeding and assimilation between the groups following spawning. A year after spawning, plasma TG levels, MLs and growth rate decreased in consecutive spawners, attributable to transfer of lipid reserves into the ovary. During the year prior to second spawning, energy reserves and plasma estradiol levels were higher in reproductive skip spawners versus consecutive spawners, reflecting the energy deficit after first spawning. These results suggest that the decision to initiate ovarian recrudescence occurs by 10 weeks after first spawning and are consistent with the differences in energy reserves acquired following spawning being a consequence of that decision. This information will increase the success of conservation projects reconditioning post-spawning summer-run steelhead trout.
Identification of the Klambothrips myopori (Thysanoptera: Phlaeothripidae) Predator Complex in California
Authors: Shogren C J , Paine T D 
Published: June 2019

Abstract
To identify the predator complex of the invasive thrips, Klambothrips myopori, on its ornamental host plant Myoporum laetum, field surveys were conducted at three sites in southern California over the period of 1 y. Five insect orders and five spider families were represented in the survey. Although the most abundant groups differed among collection sites, syrphid larvae, anthocorids, Chrysoperla spp., Franklinothrips orizabensis Johansen (Thysanoptera: Aeolothripidae), and one spider family (Salticidae) were all collected at each site. Based on the field surveys, Orius spp. and Chrysoperla spp. were identified as possible key natural enemies of K. myopori. Laboratory studies were then conducted to determine the consumption rates of Orius insidiosus Say (Hemiptera: Anthocoridae) and Chrysoperla rufilabris Burmeister (Neuroptera: Chrysopidae) at constant densities of K. myopori and to define the functional responses of the predators. Both predators consumed more second-instar larvae than other prey stages. Orius insidious displayed a type II functional response, while C. rufilabris displayed both type II and type III depending on prey stage. Generally speaking, O. insidiosus and C. rufilabris consumed a higher proportion of prey at lower pest densities, implying that in an augmentative control program using these commercially available natural enemies, predators could be released early in the year when host plants begin to flush and thrips populations are low to suppress population growth.
Sex-related differences in catheter ablation of atrial fibrillation: a systematic review and meta-analysis
Authors: Cheng Xiaocheng , Hu Qiongwen , Gao Lei , Liu Jian , Qin Shu , Zhang Dongying 
Published: June 2019

Abstract

Aims
The sex-related differences in the clinical outcomes of rhythm and safety after catheter ablation remain unclear. The purpose of this study was to compare the clinical outcomes of catheter ablation for atrial fibrillation (AF) in women and men.

Methods and results
The Medline and EMBASE databases were searched for published articles up to December 2018. Studies that met our predefined inclusion criteria were included. The primary endpoints were freedom from AF/atrial tachycardia (AT) recurrence, stroke/transient ischaemic attack (TIA), and all-cause mortality. After literature search and detailed assessment, 19 observational studies (151 370 patients; 34% women) were identified. Our analyses showed that the rate of freedom from AF/AT recurrence was lower in women than men at the 2.4-year follow-up [odds ratio (OR): 0.75, 95% confidence interval (CI) 0.69–0.81; P < 0.0001]. Moreover, women had an increased risk of stroke/TIA (OR: 1.42, 95% CI 1.21–1.67; P < 0.0001) and all-cause mortality (OR: 1.53, 95% CI 1.02–2.28; P = 0.04). Nevertheless, for the endpoint of all-cause mortality, there was no significant difference between the two genders in the subgroup of prospective studies (OR: 1.19, 95% CI 0.69–2.05; P = 0.53). Additionally, women were more likely to experience major complications compared with men (pericardial effusion/tamponade, major bleeding requiring transfusion, and pacemaker implantation).

Conclusions
Women who underwent catheter ablation of AF might experience lower efficacy and a higher risk of stroke/TIA and major complications than men. The reasons for these sex-related differences need to be further studied.
Mycobacterium bovis BCG promotes IL-10 expression by establishing a SYK/PKCα/β positive autoregulatory loop that sustains STAT3 activation
Authors: Villaseñor Tomás , Madrid-Paulino Edgardo , Maldonado-Bravo Rafael , Pérez-Martínez Leonor , Pedraza-Alva Gustavo 
Published: June 2019

ABSTRACT
Mycobacterium ensures its survival inside macrophages and long-term infection by subverting the innate and adaptive immune response through the modulation of cytokine gene expression profiles. Different Mycobacterium species promote the expression of TGFβ and IL-10, which, at the early stages of infection, block the formation of the phagolysosome, thereby securing mycobacterial survival upon phagocytosis, and at later stages, antagonize IFNγ production and functions. Despite the key role of IL-10 in mycobacterium infection, the signal transduction pathways leading to IL-10 expression in infected macrophages are poorly understood. Here, we report that Mycobacterium bovis BCG promotes IL-10 expression and cytokine production by establishing a SYK/PKCα/β positive feedback loop that leads to STAT3 activation.
The Population Structure of Pseudomonas aeruginosa Is Characterized by Genetic Isolation of exoU+ and exoS+ Lineages
Authors: Ozer Egon A , Nnah Ekpeno , Didelot Xavier , Whitaker Rachel J , Hauser Alan R 
Published: June 2019

AbstractThe diversification of microbial populations may be driven by many factors including adaptation to distinct ecological niches and barriers to recombination. We examined the population structure of the bacterial pathogen Pseudomonas aeruginosa by analyzing whole-genome sequences of 739 isolates from diverse sources. We confirmed that the population structure of P. aeruginosa consists of two major groups (referred to as Groups A and B) and at least two minor groups (Groups C1 and C2). Evidence for frequent intragroup but limited intergroup recombination in the core genome was observed, consistent with sexual isolation of the groups. Likewise, accessory genome analysis demonstrated more gene flow within Groups A and B than between these groups, and a few accessory genomic elements were nearly specific to one or the other group. In particular, the exoS gene was highly overrepresented in Group A compared with Group B isolates (99.4% vs. 1.1%) and the exoU gene was highly overrepresented in Group B compared with Group A isolates (95.2% vs. 1.8%). The exoS and exoU genes encode effector proteins secreted by the P. aeruginosa type III secretion system. Together these results suggest that the major P. aeruginosa groups defined in part by the exoS and exoU genes are divergent from each other, and that these groups are genetically isolated and may be ecologically distinct. Although both groups were globally distributed and caused human infections, certain groups predominated in some clinical contexts.
Structure of the Séchilienne unstable slope from large-scale three-dimensional electrical tomography using a Resistivity Distributed Automated System (R-DAS)
Authors: Lajaunie M , Gance J , Nevers P , Malet J-P , Bertrand C , Garin T , Ferhat G 
Published: June 2019

SUMMARY
This work presents a 3-D resistivity model of the Séchilienne unstable slope acquired with a network of portable resistivimeters in summer 2017. The instrumentation consisted in distributed measuring systems (IRIS Instruments FullWaver) to measure the spatial variations of electrical potential. 23 V-FullWaver receivers with two 50 m dipoles have been deployed over an area of circa 2 km2; the current was injected between a fixed remote electrode and a mobile electrode grounded successively at 30 locations. The data uncertainty has been evaluated in relation to the accuracy of electrodes positioning. The software package BERT (Boundless Electrical Resistivity Tomography) is used to invert the apparent resistivity and model the complex data set providing the first 3-D resistivity model of the slope. Stability tests and synthetic tests are realized to assess the interpretability of the inverted models. The 3-D resistivity model is interpreted up to a depth of 500 m; it allows identifying resistive and conductive anomalies related to the main geological and hydrogeological structures shaping the slope. The high fracturation of the rock in the most active zone of the landslide appears as a resistive anomaly where the highest resistivity values are located close to the faults. A major drain formed by a fault in the unaltered micaschist is identified through the discharge of a perched aquifer along the conductive zone producing an important conductive anomaly contrasting with the unaltered micaschist.
Combined analysis of keratinocyte cancers identifies novel genome-wide loci
Authors: Liyanage Upekha E , Law Matthew H , Han Xikun , An Jiyuan , Ong Jue-Sheng , Gharahkhani Puya , Gordon Scott , Neale Rachel E , Olsen Catherine M ,   23andMe Research Team, MacGregor Stuart , Whiteman David C 
Published: June 2019

Abstract
The keratinocyte cancers (KC), basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) are the most common cancers in fair-skinned people. KC treatment represents the second highest cancer healthcare expenditure in Australia. Increasing our understanding of the genetic architecture of KC may provide new avenues for prevention and treatment. We first conducted a series of genome-wide association studies (GWAS) of KC across three European ancestry datasets from Australia, Europe and USA, and used linkage disequilibrium (LD) Score regression (LDSC) to estimate their pairwise genetic correlations. We employed a multiple-trait approach to map genes across the combined set of KC GWAS (total N = 47 742 cases, 634 413 controls). We also performed meta-analyses of BCC and SCC separately to identify trait specific loci. We found substantial genetic correlations (generally 0.5–1) between BCC and SCC suggesting overlapping genetic risk variants. The multiple trait combined KC GWAS identified 63 independent genome-wide significant loci, 29 of which were novel. Individual separate meta-analyses of BCC and SCC identified an additional 13 novel loci not found in the combined KC analysis. Three new loci were implicated using gene-based tests. New loci included common variants in BRCA2 (distinct to known rare high penetrance cancer risk variants), and in CTLA4, a target of immunotherapy in melanoma. We found shared and trait specific genetic contributions to BCC and SCC. Considering both, we identified a total of 79 independent risk loci, 45 of which are novel.
Statutory rights and de facto constitutional supremacy in Hong Kong?
Authors: Yap Po Jen , Chung Francis 
Published: June 2019

Abstract
Fundamental rights in the Hong Kong Special Administrative Region (Hong Kong) are protected in its Basic Law and the Hong Kong Bill of Rights Ordinance (BORO). The Hong Kong Basic Law enshrines most of the BORO rights, thereby expressly conferring constitutional status on these rights. But there are a number of BORO rights that are not protected in the Basic Law. This article analyzes the cases in which the Hong Kong judiciary has addressed disputes concerning three exclusive BORO rights: (i) the right to participate in public affairs; (ii) the right to a fair hearing in civil cases; and (iii) the prohibition against cruel, inhuman, or degrading treatment or punishment. We will also explain how the courts have conferred de facto constitutional supremacy on all these statutory rights, while simultaneously providing significant leeway and decisional space for the government to craft a considered response in their remedial legislation, thereby promoting a constitutional dialogue between the judiciary and the government on rights-protection in Hong Kong.
Discs large homolog 1 regulates B-cell proliferation and antibody production
Authors: Dong Xuejiao , Li Xinxin , Liu Ce , Xu Kun , Shi Yi , Liu Wanli 
Published: June 2019

Abstract
Antibody production results from B-cell activation and proliferation upon antigen binding. Discs large homolog 1 (Dlg1), a scaffold protein from the membrane-associated guanylate kinase family, has been shown to regulate the antigen receptor signaling and cell polarity in lymphocytes; however, the physiological function of Dlg1 in humoral responses is not completely clear. Here, we addressed this question using a conditional knockout (KO) mouse model with Dlg1 deficiency in different B-cell subsets by crossing dlg1fl/fl mice with either mb1cre/+ or aicdacre/+ mice, respectively. In both mouse models, we observed that Dlg1 deficiency in B cells (Dlg1-KO B cells) led to obvious hyper-antibody responses upon immunization, the effect of which was more obvious in antigen-recall responses. Mechanistically, we found that Dlg1-KO B cells exhibited hyper-proliferation compared with wild-type B cells upon antigen stimulation, suggesting that the hyper-antibody responses are likely induced by the hyper-proliferation of Dlg1-KO B cells. Indeed, further studies demonstrated that Dlg1 deficiency in B cells led to the down-regulation of a tumor suppressor, FoxO1. Thus, all these results reveal an unexpected function of Dlg1 in restraining hyper-antibody responses through the inhibition of FoxO1 and thus antigen-binding-induced proliferation in B cells.
Methyl Benzoate as a Putative Alternative, Environmentally Friendly Fumigant for the Control of Stored Product Insects
Authors: Morrison William R , Larson Nicholas L , Brabec Daniel , Zhang Aijun 
Published: June 2019

Abstract
Historically, stored product insect pest management has been based around the use of methyl bromide and phosphine as fumigants. However, methyl bromide has been phased out for structural fumigations, and there is increasing worldwide insecticide resistance to phosphine. One potential alternative, environmentally friendly option is the use of methyl benzoate (MBe), which is considered a food safe compound. In this study, we evaluated the direct and sublethal effects of MBe exposure on the survivorship and mobility of four stored product species with diverse life histories, including Rhyzopertha dominica, Tribolium castaneum, Sitophilus zeamais, and Trogoderma variabile. Sets of insects were exposed to a control, low, or high MBe concentrations in flasks with or without food for 24 or 72 h in the laboratory. Furthermore, we assessed phosphine exposure under similar conditions. Overall, R. dominica was the most susceptible to MBe exposure, followed by T. castaneum. By contrast, S. zeamais and T. variabile were relatively unaffected by MBe exposure. Exposure to MBe induced multiple-fold decreases in the total distance moved and velocity of adults still considered alive or affected after assays. By comparison, phosphine effectively killed all individuals of all species. Our data suggest that while MBe was effective for R. dominica, it was not competitive in comparison to phosphine for controlling susceptible strains of these species at the specified experimental conditions.
Mechanisms behind strong strata behaviour in high longwall mining face-ends under shallow covers
Authors: Zhu Weibing , Qi Xiangrui , Ju Jinfeng , Xu Jingmin 
Published: June 2019

Abstract
Safe and efficient mining of shallow coal seams relies on the understanding and effective control of strata behaviour. Field measurements, theoretical analysis and numerical simulations are presented in this study to investigate the mechanism behind abnormal strata behaviour, such as roof collapse and severe roadway deformation, that occurs in high longwall face-ends under shallow cover. We observed that coal pillars with two sides being mined out become unstable when the cover depth exceeds a certain value. The instability of the coal pillar can alter the fracture line of the overlying strata, triggering a reversed rotation of the ‘curved triangle blocks’ that form after the breakage of the overlying main roof. The revolving blocks apply stress on the roof strata directly above the longwall face-end, resulting in roof collapse. The collapse of both the coal pillars and the roof also leads to the advancement and increase of the overlying abutment pressure, which further causes severe roadway deformation in front of the working face. The strong strata behaviour that occurs in high longwall face-ends with shallow cover is presented in this study and countermeasures are proposed, such as widening or strengthening the coal pillar, or implementing destress blasting. The countermeasures we proposed and the results of our analyses may facilitate the safe mining of shallow coal seams with similar problems in the future, and may improve the safety and efficient working of coal mines.
CEP3 levels affect starvation-related growth responses of the primary root
Authors: Delay Christina , Chapman Kelly , Taleski Michael , Wang Yaowei , Tyagi Sonika , Xiong Yan , Imin Nijat , Djordjevic Michael A 
Published: June 2019

AbstractCEPs (C-TERMINALLY ENCODED PEPTIDEs) inhibit Arabidopsis primary root growth by unknown mechanisms. We investigated how CEP3 levels control primary root growth. CEP3 peptide application decreased cell division, S-phase cell number, root meristematic cell number, and meristem zone (MZ) size in a dose- and CEP RECEPTOR1-dependent manner. Grafting showed that CEP3-dependent growth inhibition requires root and shoot CEPR1. CEP3 induced mitotic quiescence in MZ cells significantly faster than that induced by nutrient limitation alone. CEP3 also inhibited the restoration of S-phase to mitotically quiescence cells by nutrient resupply without quantitatively reducing TARGET OF RAPAMYCIN (TOR) kinase activity. In contrast, cep3-1 had an increased meristem size and S-phase cell number under nitrogen (N)-limited conditions, but not under N-sufficient conditions. Furthermore, cep3-1 meristematic cells remained in S-phase longer than wild-type cells during a sustained carbon (C) and N limitation. RNA sequencing showed that CEP3 peptide down-regulated genes involved in S-phase entry, cell wall and ribosome biogenesis, DNA replication, and meristem expansion, and up-regulated genes involved in catabolic processes and proteins and peptides that negatively control meristem expansion and root growth. Many of these genes were reciprocally regulated in cep3-1. The results suggest that raising CEP3 induces starvation-related responses that curtail primary root growth under severe nutrient limitation.
Taking the path computably traveled
Authors: Franklin Johanna N Y , Turetsky Dan 
Published: June 2019

Abstract
We define a real $A$ to be low for paths in Baire space (or Cantor space) if every $\varPi ^0_1$ class with an $A$-computable element has a computable element. We prove that lowness for paths in Baire space and lowness for paths in Cantor space are equivalent and, furthermore, that these notions are also equivalent to lowness for isomorphism.
The study of unclassified B[e] stars and candidates in the Galaxy and Magellanic Clouds†
Authors: Condori C A H , Borges Fernandes M , Kraus M , Panoglou D , Guerrero C A 
Published: June 2019

ABSTRACT
We investigated 12 unclassified B[e] stars or candidates, 8 from the Galaxy, 2 from the Large Magellanic Cloud (LMC), and 2 from the Small Magellanic Cloud (SMC). Based on the analysis of high-resolution spectroscopic (FEROS) and photometric data, we confirmed the presence of the B[e] phenomenon for all objects of our sample, except for one (IRAS 07455-3143). We derived their effective temperature, spectral type, luminosity class, interstellar extinction and, using the distances from Gaia DR2, we obtained their bolometric magnitude, luminosity, and radius. Modelling of the forbidden lines present in the FEROS spectra revealed information about the kinematics and geometry of the circumstellar medium of these objects. In addition, we analysed the light curves of four stars, finding their most probable periods. The evolutionary stage of 11 stars of our sample is suggested from their position on the HR diagram, taking into account evolutionary tracks of stars with solar, LMC, and SMC metallicities. As results, we identified B and B[e] supergiants, B[e] stars probably at the main sequence or close to its end, post-AGB and HAeB[e] candidates, and A[e] stars in the main sequence or in the pre-main sequence. However, our most remarkable results are the identification of the third A[e] supergiant (ARDB 54, the first one in the LMC), and of an ‘LBV impostor’ in the SMC (LHA 115-N82).
A joint ALMA–Bolocam–Planck SZ study of the pressure distribution in RX J1347.5−1145
Authors: Di Mascolo Luca , Churazov Eugene , Mroczkowski Tony 
Published: June 2019

ABSTRACT
We report the joint analysis of single-dish and interferometric observations of the Sunyaev–Zeldovich (SZ) effect from the galaxy cluster RX J1347.5−1145. We have developed a parametric fitting procedure that uses native imaging and visibility data, and tested it using the rich data sets from ALMA, Bolocam, and Planck available for this object. RX J1347.5−1145 is a very hot and luminous cluster showing signatures of a merger. Previous X-ray-motivated SZ studies have highlighted the presence of an excess SZ signal south-east of the X-ray peak, which was generally interpreted as a strong shock-induced pressure perturbation. Our model, when centred at the X-ray peak, confirms this. However, the presence of two almost equally bright giant elliptical galaxies separated by ∼100 kpc makes the choice of the cluster centre ambiguous, and allows for considerable freedom in modelling the structure of the galaxy cluster. For instance, we have shown that the SZ signal can be well described by a single smooth ellipsoidal generalized Navarro–Frenk–White profile, where the best-fitting centroid is located between the two brightest cluster galaxies. This leads to a considerably weaker excess SZ signal from the south-eastern substructure. Further, the most prominent features seen in the X-ray can be explained as predominantly isobaric structures, alleviating the need for highly supersonic velocities, although overpressurized regions associated with the moving subhaloes are still present in our model.