bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of IL-8 on survival after TARE in HCC: a comprehensive investigation and external validation from the SORAMIC trial
Authors: Schindler Aaron , Fischer Janett , Beeskow Anne-Bettina , Lincke Thomas , Ebel Sebastian , Seehofer Daniel , Denecke Timm , Veelken Rhea , Sabri Osama , Öcal Osman , Seidensticker Max , Berg Thomas , van Bömmel Florian 
Published: November 2024

Abstract
Purpose
In the treatment of hepatocellular carcinoma (HCC) with transarterial radioembolization (TARE), identifying reliable biomarkers for predicting survival outcomes remains a critical challenge. We aimed to address this gap by investigating the significance of serum cytokines associated with inflammation as potential biomarkers for the selection of patients for TARE.

Methods
Our retrospective study involved 161 patients diagnosed with HCC who underwent Y90 radioembolization at our medical center between 2010 and 2020. Serum samples from a subset of 78 patients were retrospectively analyzed to determine the concentrations of pro-inflammatory cytokines. The results from the prospective SORAMIC trial were used for independent validation.

Results
With a median overall survival of 36 weeks (range 4-436), our study showed the strongest correlation between 12-week survival and IL-8 levels before treatment (p < 0.001), while other relevant interleukins, interferon-α2, INF-γ, TNF-α and MCP-1 were not associated with survival. IL-8 levels below the cut-off of 190 pg/mL were significantly associated with increased 12-week and 24-week survival, with hazard ratios of 19.01 (95% CI: 2.29-157.89) and 2.57 (95% CI: 1.05–6.31), respectively (p = 0.006 and p = 0.039, respectively). In the adjusted multivariate analysis, the 190 pg/mL cut-off for IL-8 remained independently associated with 12- (p = 0.011) and 24-week survival (p = 0.039). Similarly, the SORAMIC population showed a strong association between IL-8 levels and 36-week survival (p = 0.03).

Conclusion
Our study emphasizes the pivotal role of IL-8 as a valuable parameter, demonstrating its potential for predicting treatment outcomes and assessing liver function in patients with HCC undergoing TARE. The robustness of these findings warrants further validation.
Homozygosity for a hypomorphic mutation in frizzled class receptor 5 causes syndromic ocular coloboma with microcornea in humans
Authors: Cortés-González Vianney , Rodriguez-Morales Miguel , Ataliotis Paris , Mayer Claudine , Plaisancié Julie , Chassaing Nicolas , Lee Hane , Rozet Jean-Michel , Cavodeassi Florencia , Fares Taie Lucas 
Published: November 2024

AbstractOcular coloboma (OC) is a congenital disorder caused by the incomplete closure of the embryonic ocular fissure. OC can present as a simple anomaly or, in more complex forms, be associated with additional ocular abnormalities. It can occur in isolation or as part of a broader syndrome, exhibiting considerable genetic heterogeneity. Diagnostic yield for OC remains below 30%, indicating the need for further genetic exploration. Mutations in the Wnt receptor FZD5, which is expressed throughout eye development, have been linked to both isolated and complex forms of coloboma. These mutations often result in a dominant-negative effect, where the mutated FZD5 protein disrupts WNT signaling by sequestering WNT ligands. Here, we describe a case of syndromic bilateral OC with additional features such as microcornea, bone developmental anomalies, and mild intellectual disability. Whole exome sequencing revealed a homozygous rare missense variant in FZD5. Consistent with a loss-of-function effect, overexpressing of fzd5 mRNA harboring the missense variant in zebrafish embryos does not influence embryonic development, whereas overexpression of wild-type fzd5 mRNA results in body axis duplications. However, in vitro TOPFlash assays revealed that the missense variant only caused partial loss-of-function, behaving as a hypomorphic mutation. We further showed that the mutant protein still localized to the cell membrane and maintained proper conformation when modeled in silico, suggesting that the impairment lies in signal transduction. This hypothesis is further supported by the fact that the variant affects a highly conserved amino acid known to be crucial for protein-protein interactions.
Changes to virus taxonomy and the ICTV Statutes ratified by the International Committee on Taxonomy of Viruses (2024)
Authors: Simmonds Peter , Adriaenssens Evelien M. , Lefkowitz Elliot J. , Oksanen Hanna M. , Siddell Stuart G. , Zerbini Francisco Murilo , Alfenas-Zerbini Poliane , Aylward Frank O. , Dempsey Donald M. , Dutilh Bas E. , Freitas-Astúa Juliana , García María Laura , Hendrickson R. Curtis , Hughes Holly R. , Junglen Sandra , Krupovic Mart , Kuhn Jens H. , Lambert Amy J. , Łobocka Małgorzata , Mushegian Arcady R. , Penzes Judit , Muñoz Alejandro Reyes , Robertson David L. , Roux Simon , Rubino Luisa , Sabanadzovic Sead , Smith Donald B. , Suzuki Nobuhiro , Turner Dann , Van Doorslaer Koenraad , Vandamme Anne-Mieke , Varsani Arvind 
Published: November 2024

AbstractThis article reports changes to virus taxonomy and taxon nomenclature that were approved and ratified by the International Committee on Taxonomy of Viruses (ICTV) in April 2024. The entire ICTV membership was invited to vote on 203 taxonomic proposals that had been approved by the ICTV Executive Committee (EC) in July 2023 at the 55th EC meeting in Jena, Germany, or in the second EC vote in November 2023. All proposals were ratified by online vote. Taxonomic additions include one new phylum (Ambiviricota), one new class, nine new orders, three new suborders, 51 new families, 18 new subfamilies, 820 new genera, and 3547 new species (excluding taxa that have been abolished). Proposals to complete the process of species name replacement to the binomial (genus + species epithet) format were ratified. Currently, a total of 14,690 virus species have been established.
Comparison and parametric study of characteristics of eleven types of anisotropic woods based on the behaviour of Lamb wave propagation
Authors: Zhang Bo , Othmani Cherif , Takali Farid 
Published: November 2024

Abstract
Knowledge in advance of the nine orthotropic independent elastic constants (C

ij
) of the wood medium is essential for evaluating its mechanical properties. The most prominent technique to retrieve C

ij
is the ultrasonic testing technique. This technique uses guided waves that can propagate through the material under test. Accordingly, it is worth noting that the numerical modelling of the phase and group velocities of guided waves is an unavoidable preliminary step before experimentally producing guided wave modes. Therefore, the main goal of the present work is to numerically calculate the phase velocity, group velocity and the relevant optimal incidence angles of Lamb waves in anisotropic wood that can be used as a numerical parametric study for any future experimental setup. Here, Lamb dispersion curves are calculated for eleven types of woods, where the Legendre polynomial method is employed to solve the wave equations. Moreover, the optimal incidence angle for each Lamb mode is calculated according to the Snell–Descartes law. By calculating out the three parameters of phase velocity, group velocity and optimal incidence angle of Lamb modes in eleven types of anisotropic woods, we hope to fast-track the researchers in considering the present work to facilitate their experimental measurements.
The alien and invasive plant species that may be a future conservation threat to the Lesotho Afro-alpine Drakensberg area
Authors: Mokotjomela Thabiso Michael , Vukeya Loyd Rodney , Mbele Thembelihle Joyce , Matsokane King , Munyai Tenda , Ntloko Bokang Richard , Monyatsi Mohau Peter 
Published: November 2024

AbstractIn this study, we documented and compared similarities of the alien plant species richness between South Africa represented by three provinces: Free State (FS), Eastern Cape (EC), and KwaZulu-Natal (KZN), and Lesotho—an important water source area for southern Africa. We tested the prediction that alien plant species in Lesotho are a subset of South Africa’s species partly because of the short geographical distances between the provinces and Lesotho, and environmental similarity. Overall, 7124 records containing 1040 individual alien plant species belonging to 147 families were documented. South Africa had significantly greater alien plant species records than Lesotho. Of 147 plant families, 44 were represented in both countries, and 101 families did not occur in Lesotho. Against the study prediction, the Geraniaceae and Orobanchaceae families occurred in Lesotho but not in three provinces. KwaZulu-Natal had a significantly greater number of species than Lesotho but not the other provinces, and 49% of species in three provinces originated from the Americas (i.e. South and North), Europe, and Asia. A similar pattern was observed in Lesotho. Woody and herbaceous alien plants, habitat transformers, dominated three provinces, while herbaceous species dominated Lesotho. The 62% of 1040 alien species were not listed in the South African national regulations, indicating their negative impacts are also unknown in the study region. Plant nurseries were a dominant species dispersal pathway in South Africa, while home gardens were prominent in Lesotho. We conclude that invasive plant species constitute a future threat to the Lesotho Drakensberg highlands water catchments and recommend prioritising their management and improving cross-border biosecurity between Lesotho and South Africa.
Volume of hepatoid component and intratumor M2 macrophages predict prognosis in patients with hepatoid adenocarcinoma of the stomach
Authors: Taniguchi Yoshiaki , Kiyozawa Daisuke , Kohashi Kenichi , Kawatoko Shinichiro , Yamamoto Takeo , Torisu Takehiro , Yoshizumi Tomoharu , Nakamura Masafumi , Kitazono Takanari , Oda Yoshinao 
Published: November 2024

Abstract
Background
Hepatoid adenocarcinoma of the stomach (HAS), a subtype of gastric cancer (GC), includes multiple tumor components, such as enteroblastic and tubular adenocarcinoma components. However, which component mostly contributes to the aggressive behavior of HAS remains unclear. Moreover, the role of tumor-associated macrophages (TAMs) has not been explored in HAS. This study evaluated the clinical significance of the proportion of the hepatoid component within the tumor, CD163 + macrophages, and macrophage colony-stimulating factor-1 (CSF-1) in HAS.

Methods
In total, 56 cases of primary HAS were analyzed. In each case, hepatoid (HC), enteroblastic (EC), and tubular (TC) components were identified, and the ratio of HC to the entire tumor (hepatoid component ratio, HCR) was assessed to examine the correlation between HCR and clinicopathological features. Immunohistochemical staining for CD163 and CSF-1 was performed, and differences in immunohistochemical results among the three tumor components were analyzed. In each tumor component, the prognostic impact of CD163 and CSF-1 was examined.

Results
A high HCR was associated with worse overall survival (OS). CD163 + TAMs and CSF-1 immunoreactivity score in HC were significantly higher than those in the other components. High infiltration of CD163 + TAMs and a high CSF-1 immunoreactivity score in HC were associated with an aggressive course and worse OS. Multivariate analysis revealed the proportion of HC in HAS as an independent prognostic factor (HR = 3.176, p = 0.006).

Conclusions
The HCR and CD163 + TAMs may be useful prognostic predictors, and TAMs may be novel therapeutic targets of HAS.
Dollarization in Ecuador: 2000–2024
Authors: Connolly Michael B. 
Published: November 2024

AbstractThis paper adopts a Markowitz inspired treatment of uncertainty in inflation and the exchange rate in analyzing the dollarization of Ecuador in 2000. The adoption of the U.S. dollar set a fixed price of foreign (and domestic) currency of one, with zero nominal return and zero variance. Dollarization thus stabilized inflation, guaranteed convertibility in foreign trade and resuscitated the stock exchange in Quito. The dollar served the role of the risk-free asset, save for the risk of U.S. inflation. However, in over 20 years, Ecuador has paid seigniorage to the U.S. Treasury of an accumulated $20 billion in outside money, dollar currency and coin. In 2023, we estimate an operational expense in terms of new seigniorage and the inflationary tax of slightly more than 1% of its GDP. Yet Ecuador has stabilized prices and grown more rapidly, coincidently, by 1.2%.
Three Rival Versions of Markets and the Common Good: Spontaneous, Instituted, and Civil
Authors: Hoipkemier Mark 
Published: November 2024

AbstractHow do markets principally contribute to society, and do they all contribute in the same ways? The logic of common and private goods provides much-needed clarity in grappling with the constitution and contribution of markets. The root challenge of the market is that impersonal private exchange cannot directly promote any common goods, so it appears only capable of promoting the flourishing of society “by accident,” as it were. As responses, the “spontaneous” approach regards both markets and politics as unintended orders of private ends, while a “instituted” model subordinates thin exchange to the thick communal goals of sustaining politics, and the “civil” economy claims that market exchange is itself a form of fraternal solidarity around common goods. All three rival models capture some exchange contexts, but none works for all markets. I advocate a meta stance of “market pluralism,” acknowledging that different markets’ moral architectures could match any of the three models, in line with empirical findings that different industries and market systems vary significantly in their modes of coordination, human relations, and major objectives.
Institutionalizing Sustainability: The Role of Multiple Logics in B Corp Course Integration
Authors: Lähteenkorva Maija 
Published: November 2024

AbstractSustainability has gained increased importance in business schools, yet its full institutionalization within the curricula remains challenging. To address this gap, business schools are increasingly collaborating with alternative organizations, such as B Corporations. However, the factors driving the integration of these B Corp courses into the curricula are not well understood. This study employs an institutional logic approach to examine in what way institutional logics coexist and shape the integration of B Corp courses within business school curricula. A qualitative analysis of 31 U.S. business schools revealed how the coexistence and hybridization of industry, social institution, and sustainability logic shape B Corp course framing, implementation, and perception. Industry logic drives career readiness and market alignment, social institution logic emphasizes community engagement and ethical responsibility, and sustainability logic promotes long-term impact and transformative education. This research contributes to the discourse on sustainability in business education by illustrating how multiple institutional logics can coexist constructively, offering a model for enhancing the effectiveness of sustainability initiatives in higher education.
Application of iron oxide and its composites containing carbon nanoparticles to the solution of environmental problems
Authors: Nakashima Satoru 
Published: November 2024

AbstractThe radioactive materials and the secondary waste after a nuclear power plant accident pose a big environmental problem. The nontoxic iron oxide and iron oxyhydroxide, and their composites with carbon materials were applied to solve the problem. Coal oxide produced by modified Brodie method using coal, NaOH, and γ-Fe2O3 were treated by a hydrothermal process. When the diluted dispersion mixture was treated with SrCl2, the composite particles were attracted to a magnet. On the other hand, the composite without SrCl2 was not attracted. This means only the SrCl2-adsorbed composite can be recovered by a magnet. Hematite doped with various amounts of Nb was synthesized. Its catalytic activities for photo-Fenton reaction were investigated for degradation of methylene blue (MB) in the presence of H2O2 under visible light. Nb-doped hematite calcined at 600 ºC produced smaller particles and showed higher catalytic activity than those calcined at 700 ºC. It was shown that the sample with higher Nb doping showed a better catalytic activity, i.e., the sample with 40 atomic percent of Nb calcined at 600 ºC has the highest catalytic activity. The hematite with 7.4 atomic percent of Nb calcined at 600 ºC showed unique characteristics since it has rapid decomposition rate of MB as well as ferrimagnetic-like characteristics, which makes it separable by a magnet. The polymorphism of iron(III) oxyhydroxide was controlled by adding acetic acid, ethylenediamine, and citric acid. The lepidocrocite obtained by adding the additive of citric acid resulted in the presence of citric acid in the particles and revealed a large specific surface area and negative Zeta potential, which showed an extremely high catalytic activity of MB decomposition for photo-Fenton reaction.
From itinerary to map, with “urban villagers” in the Romanian novel. A literary cartography
Authors: Bako Alina 
Published: November 2024

AbstractThe present study has as its starting point a theoretical framework contained in the Neohelicon Journal previous numbers, to which recent studies relating literature and space are added, not from a common, geographical perspective, but demonstrating that the evolution of the novel is observed through the narrative analysis of the itinerary and the map. The case studies are taken from Romanian prose, the common point being the reference to space: Ion Ghica’s, A Journey from Bucharest to Iași before 1848, Duiliu Zamfirescu Love in the Countryside, Nicolae Rădulescu-Niger’s On the Azure Coast. A Winter in Menton in 1914, Camil Petrescu’s The Last Night of Love, the First Night of War and Hortensia Papadat-Bengescu’s The Disheveled Maidens. Our approach observes the interactions between rural and urban areas, their coexistence, and the inevitable presence of the “urban villager” who is connected to the functioning of the entire society, not only Romanian, but especially the “insular” or “peninsular” one, in the terms of Fernando Cabo Aseguinolaza.
Stopping criteria for nonlinear variational problems: iterative approach
Authors: Kamdem Jules Djoko , Sayah Toni 
Published: November 2024

AbstractIn this paper, we present and study a stopping criteria based on a priori error estimate for nonlinear variational problems. We show that for nonlinear variational problems, the a priori error estimate is divided into two sub errors namely: the discretization error and the linearization error. We then used that representation to devise a stopping criteria that help to reduce the computational time. The methodology is applied to three problems and the numerical results demonstrate the superiority of the new approach.
Marcuse, Capitalism, and the One-Dimensional Student
Authors: Oskay Filiz , Ballard W. Walker 
Published: November 2024

Abstract
Drawing on critical theorist Herbert Marcuse’s analysis of modern technological society in his 1964 book, One-Dimensional Man, this article argues that the forces of one-dimensionality that characterize citizens under capitalism have necessarily found their way into schools, leading to what we see as an epidemic of the one-dimensional student. Where other scholars have focused on the impacts of capitalism on schooling and possible structural reform efforts through educational policy, this analysis takes seriously the role of the individual in overcoming an all too easy tendency toward one-dimensional thinking. Applying Marcuse’s fundamental concepts of one-dimensionality, the authors point to the ways in which schools and society actively teach and promote one-dimensionality. Through this application of Marcuse to the field of education, the authors uncover the subtle ways that schools shape the consciousness of students, and in doing so perpetuate one-dimensional society. The article concludes with a number of solutions that reassess educational aims to be more in tune with the sharpening of critical consciousness, or what Marcuse calls negative thinking, for the sake of freedom of self and society.
A putative hemicellulose gene promoter drives high levels of expression in guard cells and stem epidermis of poplar and highlights hormone regulation of cell wall formation
Authors: Wang Dan , Coleman Heather D. 
Published: November 2024

AbstractForest trees generate substantial quantities of organic carbon, recognized as a renewable and economically viable resource for applications in bioenergy and industry. This study specifically focuses on xylan, a major hemicellulose component in poplar, and on the role of PtrPARVUS2—a member of the glycosyltransferase 8 family genes involved in xylan biosynthesis. PtrPARVUS2 is hypothesized to exhibit tissue-specific activity, and here we assessed its promoter via bioinformatic analysis, revealing motifs associated with responsiveness to hormones including Gibberellic Acid (GA), Methyl Jasmonate (MeJA), Auxin, and Abscisic Acid (ABA), among others. Treatment with hormones, including ABA, 1-naphthaleneacetic acid, a synthetic auxin, MeJA, and GA, demonstrated a swift inhibition of PtrPARVUS2 transcription. Analysis of expression patterns in wildtype trees indicated heightened expression in vascular tissues, particularly the bark. Transgenic lines expressing Enhanced Green Fluorescent Protein and β-glucuronidase under the control of the PtrPARVUS2 promoter confirmed tissue-specific activity, particularly in guard cells, stem epidermis, and developing xylem. These results offer understanding into the potential functions of PtrPARVUS2 in terms of phytohormone response and the formation of guard cell walls. The investigation introduces a valuable promoter for specific biotechnological applications in guard cells and stem epidermal cells. Additional research is required to elucidate the precise regulatory mechanisms of PtrPARVUS2 in the future.
Integrating historical approaches of university ecosystems: reviewing the literature streams and future directions
Authors: Marchant-Pérez Paula , Ferreira João J. 
Published: November 2024

AbstractIt is practically consensual that universities contribute to economic and social growth; therefore, they nowadays need to play a more active role in answering the changing needs of society. In addition, universities hold the potential to promote regional innovation through their influence over the ecosystems they participate in. This article aims to identify, analyse and integrate the historical approaches of university ecosystems and university roles through a systematic literature review. The findings identify four different periods: (i) University-Industry collaboration (until 2000); (ii) changing the university model into a triple-helix model (2001–2010); (iii) from the triple to the quadruple-helix model in the knowledge society (2011–2020); and (iv) ecosystem complexity and the Neo Triple-Helix Model (from 2021). The study contributes to the literature on universities and the ecosystem by providing a unified perspective on the importance of the university’s role in the economic and social growth of the knowledge business and the evolution of the ecosystem. These results provide an overview of the trends in university ecosystems, including an integrative framework, research themes, and research questions able to guide future studies.