bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Hermeneutics of Silk: China and the Fabric of Christendom according to Martino Martini and the Early Modern Jesuit “Accommodationists”
Authors: Yeh Alice 
Published: April 2019

AbstractAs Jesuit missionaries in seventeenth-century China struggled to translate Christian theology into Chinese terms and categories, they embarked on a project of purifying the “political” from the “superstitious.” Their project was structured by the unmentionable: the proscribed luxury of silk robes that facilitated the encounters between the missionaries and the native elite they most sought to convert. This article examines the manifold functions of silk and the problem of “accommodation” by turning to theBrevis relatio de numero et qualitate Christianorum apud Sinas(“Brief report on the number and quality of Christians in China”), a booklet authored by the Jesuit missionary Martino Martini (1614–1661). Written for European circulation, theBrevis relatiotouted the triumphs of the mission by incorporating the conceptual imaginary of “China” into the cosmo-political confines of the Euro-Christian world. This article shows how the basic Christian metaphor of horticultural fruitfulness was used to interpret silk and sericulture as material evidence that the Chinese mission field prefigured and promised, both spiritually and commercially, a profitable harvest.
Attracting skilled labour to the North: Migration loss and policy implications across Russia’s diverse Arctic regions
Authors: Khoreva Ol’ga , Konchakov Roman , Leonard Carol Scott , Tamitskiy Aleksandr , Zaikov Konstantin 
Published: April 2019

AbstractThis paper identifies education, skills training and improved social infrastructure as key development issues to address population decline in regions of steady out-migration from the Russian Arctic. Migration flows have mostly stabilised after the sharp and unexpectedly large population decline in the Arctic in the 1990s, during the transition to a market economy. However, the trends set in motion during that collapse, including falling general levels of education, declining size of all but the largest cities, and ageing of the populace, are becoming more serious for some regions, even where government resettlement programmes exist. As young professionals continue to leave, resettling compatriots and hiring shift labour may contribute to the vitality of more resilient regions, for example, Krasnoyarsk and Yamalo-Nenets. However, the European part of the Russian Arctic, despite its critical importance to commerce and to military security, and despite assistance programmes and subsidies, is conforming more to the ageing, less productive contours of neighbouring Arctic states on the periphery of Europe.
Water Use Dynamics in Double Cropping of Rainfed Upland Rice and Irrigated Melons Produced Under Drought‐Prone Tropical Conditions
Authors: Morillas L. , Hund S. V. , Johnson M. S. 
Published: April 2019

AbstractAgricultural expansion and intensification is occurring in seasonally dry regions of Central America, while droughts are intensifying due to increasing water demand and climatic change. Empirical measurements of water consumption of major crops in this region are scarce but crucial to assess agricultural water use dynamics in the light of increasing regional water conflicts. We empirically quantify total crop water use (CWU) and water footprints (WFs) of rainfed upland rice (wet season) and groundwater‐irrigated melons (dry season) grown sequentially as a double cropping system, one of the major cropping systems in the seasonally dry province of Guanacaste in northwestern Costa Rica. Data for this study cover 2 years and were measured with a state‐of‐the‐art eddy covariance water and carbon flux station. Upland rice only consumed green water (CWUgreen = 383 L/m2), while melons only consumed blue water (CWUblue = 177 L/m2). Irrigation was found to be 1.5 times larger than the actual melon water consumption, with better irrigation efficiencies than reported for melon farms in Brazil but slightly inferior to farms in Spain. Melon WFblue was 79 m3/t, a much lower value than global and regional estimates reported but similar to values reported for melons produced in Brazil or Spain. Upland rice WFgreen (681 m3/t) was reported for the first time and was proven to be much lower than flood irrigated‐rice WFblue‐green. Our results demonstrated lower overall water demand for upland rice‐melon double crop compared to the two other major monocultures of the region (flood‐irrigated rice and irrigated sugar cane).
Thank You to Our 2018 Peer Reviewers
Authors: Filippelli Gabriel , Colwell Rita , Anenberg Susan C. , Balbus John M. , Ceccarelli Daniela , Hudson‐Edwards Karen , Jutla Antarpreet , Miao Chiyuan , Sandifer Paul A. , Vengosh Avner 
Published: April 2019

AbstractPublic trust in science, effective science communication, and rapid and constructive response to authors about their submissions are of paramount importance to the scientific enterprise and indeed to society itself. This is really at the heart of peer review—providing thoughtful insights into both the scientific quality and importance of work, and also how it is communicated to other scientists and increasingly to a broader audience. Very few opportunities exist to acknowledge the mostly anonymous process of peer review, especially given the huge increase in review requests and the relatively mechanical nature of online reviewing platforms. We continue to be humbled by the time, effort, and careful insights that our colleagues share with each other through the process of peer review. In 2018, GeoHealth benefited from more than 83 reviews provided by 53 of our peers for papers submitted to the journal. Thank you all for your awesome efforts toward advancing geohealth now and for the future.
Androgen receptor regulates ASS1P3/miR-34a-5p/ASS1 signaling to promote renal cell carcinoma cell growth
Authors: Wang Kefeng , Sun Yin , Guo Changcheng , Liu Tao , Fei Xiang , Chang Chawnshang 
Published: April 2019

AbstractRecent studies have demonstrated that the androgen receptor (AR) could play important roles to promote renal cell carcinoma (RCC) cell proliferation, and other studies have also indicated that suppressing the argininosuccinate synthase 1 (ASS1) could promote proliferation of various tumors. The potential of AR promoting cell proliferation in RCC via altering ASS1, however, remains unclear. Here we found that the expression of ASS1 was lower in RCC tissues than in adjacent normal renal tissues, and a lower ASS1 expression was linked to a worse prognosis in RCC patients. Mechanism dissection showed that AR could decrease ASS1 expression to promote RCC cell proliferation via ASS1P3, a pseudogene of ASS1. The results of RIP assay and AGO2 assay revealed that AR could bind ASS1P3 to increase RCC cell proliferation via altering miR-34a-5p function, which could bind to the 3′UTR of ASS1 to suppress its protein expression. ASS1P3 could function as a miRNA decoy for miR-34a-5p to regulate ASS1 in RCC. Preclinical study also supports the in vitro data. Together, these results demonstrated that ASS1P3 could function as a competing endogenous RNA to suppress RCC cell progression, and targeting this newly identified AR-mediated ASS1P3/miR-34a-5p/ASS1 signaling might help in blocking proliferation.
H3K27M induces defective chromatin spread of PRC2-mediated repressive H3K27me2/me3 and is essential for glioma tumorigenesis
Authors: Harutyunyan Ashot S. , Krug Brian , Chen Haifen , Papillon-Cavanagh Simon , Zeinieh Michele , De Jay Nicolas , Deshmukh Shriya , Chen Carol C. L. , Belle Jad , Mikael Leonie G. , Marchione Dylan M. , Li Rui , Nikbakht Hamid , Hu Bo , Cagnone Gael , Cheung Warren A. , Mohammadnia Abdulshakour , Bechet Denise , Faury Damien , McConechy Melissa K , Pathania Manav , Jain Siddhant U. , Ellezam Benjamin , Weil Alexander G. , Montpetit Alexandre , Salomoni Paolo , Pastinen Tomi , Lu Chao , Lewis Peter W. , Garcia Benjamin A. , Kleinman Claudia L. , Jabado Nada , Majewski Jacek 
Published: April 2019

AbstractLys-27-Met mutations in histone 3 genes (H3K27M) characterize a subgroup of deadly gliomas and decrease genome-wide H3K27 trimethylation. Here we use primary H3K27M tumor lines and isogenic CRISPR-edited controls to assess H3K27M effects in vitro and in vivo. We find that whereas H3K27me3 and H3K27me2 are normally deposited by PRC2 across broad regions, their deposition is severely reduced in H3.3K27M cells. H3K27me3 is unable to spread from large unmethylated CpG islands, while H3K27me2 can be deposited outside these PRC2 high-affinity sites but to levels corresponding to H3K27me3 deposition in wild-type cells. Our findings indicate that PRC2 recruitment and propagation on chromatin are seemingly unaffected by K27M, which mostly impairs spread of the repressive marks it catalyzes, especially H3K27me3. Genome-wide loss of H3K27me3 and me2 deposition has limited transcriptomic consequences, preferentially affecting lowly-expressed genes regulating neurogenesis. Removal of H3K27M restores H3K27me2/me3 spread, impairs cell proliferation, and completely abolishes their capacity to form tumors in mice.
Foliar-feeding insects acquire microbiomes from the soil rather than the host plant
Authors: Hannula S. Emilia , Zhu Feng , Heinen Robin , Bezemer T. Martijn 
Published: April 2019

AbstractMicrobiomes of soils and plants are linked, but how this affects microbiomes of aboveground herbivorous insects is unknown. We first generated plant-conditioned soils in field plots, then reared leaf-feeding caterpillars on dandelion grown in these soils, and then assessed whether the microbiomes of the caterpillars were attributed to the conditioned soil microbiomes or the dandelion microbiome. Microbiomes of caterpillars kept on intact plants differed from those of caterpillars fed detached leaves collected from plants growing in the same soil. Microbiomes of caterpillars reared on detached leaves were relatively simple and resembled leaf microbiomes, while those of caterpillars from intact plants were more diverse and resembled soil microbiomes. Plant-mediated changes in soil microbiomes were not reflected in the phytobiome but were detected in caterpillar microbiomes, however, only when kept on intact plants. Our results imply that insect microbiomes depend on soil microbiomes, and that effects of plants on soil microbiomes can be transmitted to aboveground insects feeding later on other plants.
Genome-scale Capture C promoter interactions implicate effector genes at GWAS loci for bone mineral density
Authors: Chesi Alessandra , Wagley Yadav , Johnson Matthew E. , Manduchi Elisabetta , Su Chun , Lu Sumei , Leonard Michelle E. , Hodge Kenyaita M. , Pippin James A. , Hankenson Kurt D. , Wells Andrew D. , Grant Struan F. A. 
Published: April 2019

AbstractOsteoporosis is a devastating disease with an essential genetic component. GWAS have discovered genetic signals robustly associated with bone mineral density (BMD), but not the precise localization of effector genes. Here, we carry out physical and direct variant to gene mapping in human mesenchymal progenitor cell-derived osteoblasts employing a massively parallel, high resolution Capture C based method in order to simultaneously characterize the genome-wide interactions of all human promoters. By intersecting our Capture C and ATAC-seq data, we observe consistent contacts between candidate causal variants and putative target gene promoters in open chromatin for ~ 17% of the 273 BMD loci investigated. Knockdown of two novel implicated genes, ING3 at ‘CPED1-WNT16’ and EPDR1 at ‘STARD3NL’, inhibits osteoblastogenesis, while promoting adipogenesis. This approach therefore aids target discovery in osteoporosis, here on the example of two relevant genes involved in the fate determination of mesenchymal progenitors, and can be applied to other common genetic diseases.
Metabolic potential of uncultured bacteria and archaea associated with petroleum seepage in deep-sea sediments
Authors: Dong Xiyang , Greening Chris , Rattray Jayne E. , Chakraborty Anirban , Chuvochina Maria , Mayumi Daisuke , Dolfing Jan , Li Carmen , Brooks James M. , Bernard Bernie B. , Groves Ryan A. , Lewis Ian A. , Hubert Casey R. J. 
Published: April 2019

AbstractThe lack of microbial genomes and isolates from the deep seabed means that very little is known about the ecology of this vast habitat. Here, we investigate energy and carbon acquisition strategies of microbial communities from three deep seabed petroleum seeps (3 km water depth) in the Eastern Gulf of Mexico. Shotgun metagenomic analysis reveals that each sediment harbors diverse communities of chemoheterotrophs and chemolithotrophs. We recovered 82 metagenome-assembled genomes affiliated with 21 different archaeal and bacterial phyla. Multiple genomes encode enzymes for anaerobic oxidation of aliphatic and aromatic compounds, including those of candidate phyla Aerophobetes, Aminicenantes, TA06 and Bathyarchaeota. Microbial interactions are predicted to be driven by acetate and molecular hydrogen. These findings are supported by sediment geochemistry, metabolomics, and thermodynamic modelling. Overall, we infer that deep-sea sediments experiencing thermogenic hydrocarbon inputs harbor phylogenetically and functionally diverse communities potentially sustained through anaerobic hydrocarbon, acetate and hydrogen metabolism.
Self-organization of Plk4 regulates symmetry breaking in centriole duplication
Authors: Yamamoto Shohei , Kitagawa Daiju 
Published: April 2019

AbstractDuring centriole duplication, a single daughter centriole is formed next to the mother centriole. The molecular mechanism that determines a single duplication site remains a long-standing question. Here, we show that intrinsic self-organization of Plk4 is implicated in symmetry breaking in the process of centriole duplication. We demonstrate that Plk4 has an ability to phase-separate into condensates via an intrinsically disordered linker and that the condensation properties of Plk4 are regulated by autophosphorylation. Consistently, the dissociation dynamics of centriolar Plk4 are controlled by autophosphorylation. We further found that autophosphorylated Plk4 is already distributed as a single focus around the mother centriole before the initiation of procentriole formation, and is subsequently targeted for STIL-HsSAS6 loading. Perturbation of Plk4 self-organization affects the asymmetry of centriolar Plk4 distribution and proper centriole duplication. Overall, we propose that the spatial pattern formation of Plk4 is a determinant of a single duplication site per mother centriole.
Integrating temporal and spatial control of electronic transitions for bright multiphoton upconversion
Authors: Sun Tianying , Li Yuhua , Ho Wai Lok , Zhu Qi , Chen Xian , Jin Limin , Zhu Haomiao , Huang Bolong , Lin Jun , Little Brent E. , Chu Sai Tak , Wang Feng 
Published: April 2019

AbstractThe applications of lanthanide-doped upconversion nanomaterials are limited by unsatisfactory brightness currently. Herein, a general strategy is proposed for boosting the upconversion efficiency in Er3+ ions, based on combined use of a core−shell nanostructured host and an integrated optical waveguide circuit excitation platform. A NaErF4@NaYF4 core−shell nanoparticle is constructed to host the upconversion process for minimizing non-radiative dissipation of excitation energy by surface quenchers. Furthermore, an integrated optical microring resonator is designed to promote absorption of excitation light by the nanoparticles, which alleviates quenching of excited states due to cross-relaxation and phonon-assisted energy transfer. As a result, multiphoton upconversion emission with a large anti-Stokes shift (greater than 1150 nm) and a high energy conversion efficiency (over 5.0%) is achieved under excitation at 1550 nm. These advances in controlling photon upconversion offer exciting opportunities for important photonics applications.
Estrogen receptor variants in ER-positive basal-type breast cancers responding to therapy like ER-negative breast cancers
Authors: Groenendijk Floris H. , Treece Tina , Yoder Erin , Baron Paul , Beitsch Peter , Audeh William , Dinjens Winand N. M. , Bernards Rene , Whitworth Pat 
Published: April 2019

AbstractImmunohistochemically ER-positive HER2-negative (ER+HER2−) breast cancers are classified clinically as Luminal-type. We showed previously that molecular subtyping using the 80-gene signature (80-GS) reclassified a subset of ER+HER2− tumors to molecular Basal-type. We report here that molecular reclassification is associated with expression of dominant-negative ER variants and evaluate response to neoadjuvant therapy and outcome in the prospective neoadjuvant NBRST study (NCT01479101). The 80-GS reclassified 91 of 694 (13.1%) immunohistochemically Luminal-type tumors to molecular Basal-type. Importantly, all 91 discordant tumors were classified as high-risk, whereas only 66.9% of ER+/Luminal-type tumors were classified at high-risk for disease recurrence (i.e., Luminal B) (P < 0.001). ER variant mRNA (ER∆3, ER∆7, and ERα-36) analysis performed on 84 ER+/Basal tumors and 48 ER+/Luminal B control tumors revealed that total ER mRNA was significantly lower in ER+/Basal tumors. The relative expression of ER∆7/total ER was significantly higher in ER+/Basal tumors compared to ER+/Luminal B tumors (P < 0.001). ER+/Basal patients had similar pathological complete response (pCR) rates following neoadjuvant chemotherapy as ER−/Basal patients (34.3 vs. 37.6%), and much higher than ER+/Luminal A or B patients (2.3 and 5.8%, respectively). Furthermore, 3-year distant metastasis-free interval (DMFI) for ER+/Basal patients was 65.8%, significantly lower than 96.3 and 88.9% for ER+/Luminal A and B patients, respectively, (log-rank P < 0.001). Significantly lower total ER mRNA and increased relative ER∆7 dominant-negative variant expression provides a rationale why ER+/Basal breast cancers are molecularly ER-negative. Identification of this substantial subset of patients is clinically relevant because of the higher pCR rate to neoadjuvant chemotherapy and correlation with clinical outcome.
Strong hopping induced Dzyaloshinskii–Moriya interaction and skyrmions in elemental cobalt
Authors: Luo Hu-Bin , Zhang Hong-Bin , Liu J. Ping 
Published: April 2019

AbstractThe Dzyaloshinskii–Moriya interaction (DMI) is well known to favor a chiral rotation of the magnetic moments, which accounts for the emergence of the skyrmions. The DMI is a combined effect of spin–orbit coupling with broken inversion symmetry in magnets. Most of the noncentrosymmetric magnetic materials that bear skyrmions involve nonmagnetic elements. This work shows that strong DMIs exist in elemental cobalt with a β-Mn-type metastable structure. The variation of DMI among different cobalt pairs largely follows the variation of hopping magnitude in which p electrons play an important role. Although the DMIs between different atomic pairs partly cancels with each other, the net interaction is sufficient to result in a left-handed Bloch-type spiral. Spin dynamics simulation shows that a critical magnetic field of 2.9 T stabilizes skyrmions at 0 K.
Amorphous FeZr metal for multi-functional sensor in electronic skin
Authors: Jung Minhyun , Lee Eunha , Kim Dongseuk , Kim Kyungkwan , Yun Changjin , Lee Hyangsook , Kim Heegoo , Rhie Kungwon , Jeon Sanghun 
Published: April 2019

AbstractThe composition of an amorphous metal, which is well known for having no slip plane or slip direction, can be tailored for enhanced strength and a lower Young’s modulus under mechanical stress. Unlike crystalline metals, elastic amorphous metals can, in principle, be used as a flexible electrode in soft, wearable electronics. A metal with a lattice structure absorbs external energy, which causes structural deformations, while an amorphous metal does not absorb energy. Therefore, amorphous metals have excellent mechanical properties that can overcome the limitations of crystalline metals. However, voids inside such metals are easily formed according to Thornton’s model, which results in the formation of mesoporous (10–50 nm) rods due to the spatial separation of metal atoms. We eliminated the porosity in amorphous metals by controlling the kinetic energy of sputtered metal atoms and ions. Optimized Fe33Zr67 has an amorphous structure with a strength of 2.88 GPa and a Young’s modulus of 76.6 GPa. With this amorphous metal, we fabricated a stretchable and multi-functional sensor for electronic skin that enables the detection of pressure, temperature and light and also serves as a heater. In this work, we demonstrate the feasibility of the amorphous metal Fe33Zr67 in soft electronics for use in various industrial applications.
Permittivity of ex vivo healthy and diseased murine skeletal muscle from 10 kHz to 1 MHz
Authors: Nagy J. A. , DiDonato C. J. , Rutkove S. B. , Sanchez B. 
Published: April 2019

AbstractA better understanding of the permittivity property of skeletal muscle is essential for the development of new diagnostic tools and approaches for neuromuscular evaluation. However, there remain important knowledge gaps in our understanding of this property in healthy and diseased skeletal muscle, which hinder its translation into clinical application. Here, we report the permittivity of gastrocnemius muscle in healthy wild type mice and murine models of spinal muscular atrophy, muscular dystrophy, diabetes, amyotrophic lateral sclerosis and in a model of myofiber hypertrophy. Data were measured ex vivo from 10 kHz to 1 MHz using the four-electrode impedance technique. Additional quantitative histology information were obtained. Ultimately, the normative data reported will offer the scientific community the opportunity to develop more accurate models for the validation and prediction of experimental observations in both pre-clinical and clinical neuromuscular disease research.
High-resolution global urban growth projection based on multiple applications of the SLEUTH urban growth model
Authors: Zhou Yuerong , Varquez Alvin C. G. , Kanda Manabu 
Published: April 2019

AbstractAs urban population is forecast to exceed 60% of the world’s population by 2050, urban growth can be expected. However, research on spatial projections of urban growth at a global scale are limited. We constructed a framework to project global urban growth based on the SLEUTH urban growth model and a database with a resolution of 30 arc-seconds containing urban growth probabilities from 2020 to 2050. Using the historical distribution of the global population from LandScanTM as a proxy for urban land cover, the SLEUTH model was calibrated for the period from 2000 to 2013. This model simulates urban growth using two layers of 50 arc-minutes grids encompassing global urban regions. While varying growth rates are observed in each urban area, the global urban cover is forecast to reach 1.7 × 106 km2 by 2050, which is approximately 1.4 times that of the year 2012. A global urban growth database is essential for future environmental planning and assessments, as well as numerical investigations of future urban climates.