bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cash cycle: A cross‐country analysis
Authors: Jalal Abu , Khaksari Shahriar 
Published: April 2019

AbstractWe study the cross‐country differences in the cash cycles of companies and find a negative relation between a country's development and the cash cycles of its corporations. The ability of companies to obtain raw materials on credit and to better manage inventory plays significant roles in shortening the cash cycle. Various country‐specific factors affect cash cycles. Firms with shorter cash cycles invest more in R&D and participate in more acquisitions. They also have a higher valuation and lower leverage. Overall, our findings indicate a close relation between a company's working capital management, its valuation, and the country's level of development.
Effect of PVP on gas‐sensing properties of ZnO micro/nanostructure materials in SDS‐PVP composite
Authors: Chen Hiaxia , Yu Hai , Cui Shu , Liu Chengyou 
Published: April 2019

AbstractZnO is often used as gas sensor. In order to increase the sensitivity of the sensors, many methods are used to change the gas‐sensing properties. In this paper, ZnO was synthesized by hydrothermal method using Zn (NO3)2 as a zinc source. Sodium lauryl sulfate (SDS) and polyvinylpyrrolidone (PVP) were added into the system to control microstructure and surface morphology of ZnO nanoparticles. The SDS was kept constant, and the PVP was changed. The morphology and composite were investigated by field emission scanning electron microscopy and X‐ray diffraction. The chemical valence of the elements was determined by X‐ray photoelectron spectroscopy. The sensing properties were investigated at different PVP components. It is found that ZnO has a red zinc structure. When the mSDS:mPVP = 1:1, the sensing sensitivity is best. The mechanism of equivalent matching structure optimization performance is proposed.
Two novel ANK1 loss‐of‐function mutations in Chinese families with hereditary spherocytosis
Authors: Hao Lili , Li Shanshan , Ma Duan , Chen Shiyu , Zhang Bowen , Xiao Deyong , Zhang Jin , Jiang Nan , Jiang Shayi , Ma Jing 
Published: April 2019

AbstractHereditary spherocytosis (HS) is the most common inherited haemolytic anaemia disorder. ANK1 mutations account for most HS cases, but pathogenicity analysis and functional research have not been widely performed for these mutations. In this study, in order to confirm diagnosis, gene mutation was screened in two unrelated Chinese families with HS by a next‐generation sequencing (NGS) panel and then confirmed by Sanger sequencing. Two novel heterozygous mutations (c.C841T, p.R281X and c.T290G, p.L97R) of the ANK1 gene were identified in the two families respectively. Then, the pathogenicity of the two new mutations and two previously reported ANK1 mutations (c.C648G, p.Y216X and c.G424T, p.E142X) were studied by in vitro experiments. The four mutations increased the osmotic fragility of cells, reduced the stabilities of ANK1 proteins and prevented the protein from localizing to the plasma membrane and interacting with SPTB and SLC4A1. We classified these four mutations into disease‐causing mutations for HS. Thus, conducting the same mutation test and providing genetic counselling for the two families were meaningful and significant. Moreover, the identification of two novel mutations enriches the ANK1 mutation database, especially in China.
The integration of new nurse practitioners into care of older adults: A survey study
Authors: Henni Silje Havrevold , Kirkevold Marit , Antypas Konstantinos , Foss Christina 
Published: April 2019

AbstractAims and objectivesTo assess Norwegian advanced geriatric nurses’ (AGNs) use of their knowledge and skills, and factors that may influence AGNs’ opportunities to use their knowledge and skills to reach their full potential.BackgroundDespite the need for nurses with advanced knowledge and skill in the care of older adults, the introduction of new advanced nursing roles has been challenging. Countries in the process of establishing advanced roles need to monitor and identify possible implementation issues.DesignA cross‐sectional descriptive survey.MethodsWe invited the total population of AGNs in Norway (n = 26) and some of their colleagues (n = 465) to answer an online questionnaire. Twenty‐three (88.5%) of the AGNs and 195 (42.0%) of the invited colleagues completed and submitted the questionnaires. The data were analysed with descriptive statistics. STROBE guidelines were used in reporting this study.ResultsOf the AGNs, 16 (69.6%) used their knowledge and skills to their full potential when providing direct care. However, a minority used their knowledge and skills to their full potential when proving indirect care (n = 11, 47.8%), teaching/supervision (n = 11, 47.8%) and coordination (n = 5, 21.8%). A total of 47 (24.1%) colleagues experienced the AGNs’ scope of practice as completely clear, and 52 (26.6%) collaborated with the AGNs several times a week. Of the colleagues, 131 (67.2%) considered the AGNs’ role and scope of practice contributed positively to a high degree to health service for older adults.ConclusionThe results indicate the need for greater focus on organisational adjustment for the AGNs to utilise their knowledge and skills to their full potential.Relevance to clinical practiceThere is a need for greater focus on organisational adjustment to integrate AGNs at the workplace, as complete integration may improve the AGNs’ use of their knowledge and skills.
Using two models of workplace facilitation to create conditions for development of a person‐centred culture: A participatory action research study
Authors: Hardiman Michele , Dewing Jan 
Published: April 2019

AbstractAims and objectivesTo examine facilitation in workplace learning where nurses are focused on creating person‐centred cultures; to provide a framework for novice and proficient facilitators/practitioners to learn in and from their own workplaces and practices; and to provide the conditions where practitioners can gain an understanding of the culture and context within their own workplace.BackgroundEvidence suggests that person‐centred cultures depend on purposeful, facilitated practice‐based learning activities. For person‐centredness to become more meaningful to nursing leaders in their daily work, focus must be placed on their acquisition and use of facilitation skills. The facilitation framework “Critical Companionship” remains an exemplar in the development of expert facilitation skills. Two sequential facilitation models were developed as “steps” towards Critical Companionship, as a framework for novice and proficient facilitators and practitioners to learn in and from their own workplaces and practices.Design and MethodsThis research, situated in a critical social science paradigm, drew on participatory action research to devise, explore and refine two facilitation models: Critical Allies and Critical Friends. The researcher adopted an insider approach to work with five nursing leaders, which was subsequently reported using the EQUATOR guidelines on best practice in reporting of participatory action research.ResultsThe results show the complexity of enabling facilitation within the workplace. Four themes and twelve subthemes emerged from the data that describe the attributes needed to facilitate workplace learning and reveal that managers can have an active role in enabling person‐centred culture development.ConclusionsThis research adds to the body of knowledge on developing person‐centred culture. It offers practical stepping stones for novice and proficient facilitators to enable embodiment of the skills necessary to facilitate learning in person‐centred cultures. The models offer a workplace‐friendly pathway with practical methods and further contribute to our understanding of how we create person‐centred cultures.Relevance to clinical practiceFacilitation of practice development and workplace learning remains the most effective methods to develop person‐centred cultures. This research introduces a pathway for clinical leaders/managers to become facilitators with their own teams, maximising the impact on the culture where care is delivered.
Developing and Piloting a School‐Based Online Adolescent Student‐Athlete Concussion Surveillance System
Authors: Shendell Derek G. , Gonzalez Lauren , Listwan Tracy A. , Pancella Joseph , Blackborow Mary , Boyd Joanna 
Published: April 2019

ABSTRACTBACKGROUNDDespite increased awareness of concussions, epidemiologic surveillance efforts have been scarce, especially among adolescents. This project, which was developed with school stakeholders (certified athletic trainers [ATCs], nurses, athletic directors), piloted a public secondary school‐based online surveillance tool for interscholastic and intramural sports and physical education‐related concussions in New Jersey during 2014‐2017 school years (SY).METHODSParticipating public high schools (5 within 4 districts) and career‐technical‐vocational education districts (2 with 5 campuses) completed forms anonymously online via PsychData within 5 days.RESULTSThere were 208 concussions reported, 115 in 2015‐2016 SY and 93 in 2016‐2017 SY. In fall 2015, 86 concussions were reported, including 16 from summer preseason. In fall 2016, 56 concussions were reported; 3 occurred during preseason. There were 7 concussions reported in winter 2016 and 16 in winter 2017. Twenty‐two concussions were reported in spring of both 2016 and 2017. Most online forms were completed in <10 minutes, usually using either desktop computers or tablets/iPads. School nurses followed by ATCs were primary sources of data entered online, usually by ATCs.CONCLUSIONSCooperation of nurses and ATCs at participating schools suggested online surveillance was valued and viable. Data inform future concussion prevention education and ongoing injury surveillance.
Lexicon for multiparameter texture assessment of snack and snack‐like foods in English, Spanish, Chinese, and Hindi
Authors: Kumar Rajesh , Chambers Edgar 
Published: April 2019

AbstractSnack food is an important part of human life across the world, in part, due to its convenience, availability, and of course its sensory qualities. Because texture is such a critical aspect of snack foods, a lexicon applicable to various processed and unprocessed snack foods (e.g., crackers, chips, vegetables, yogurt, etc.) is needed. This study also investigated how textures are experienced by vision, hand tactile, lip feel, first bite, multiple bite, and in throat swallowing. This study developed a texture lexicon for various snack foods. Eighty‐five different food products from eight countries around the world were used to create an initial lexicon. The highly trained panel used descriptive analysis techniques to identify 76 texture attributes and develop definitions, techniques, and references for product evaluation. Fifty of the products then were selected and evaluated for intensities using references. Principal component analysis of the data shows that the developed terms differentiated the products. K‐means cluster analysis was done to find the existing clusters between attributes, and correlation analysis used to find the highest correlated and uncorrelated attributes. The article presents attributes, definitions and techniques in English, Hindi, Mandarin Chinese, and Spanish.Practical applicationThe texture lexicon developed in this study for various snack foods can be useful for researchers and food manufacturers to identify and describe similarities and differences present in textures of foods to help with product development and assessment of snack categories in various countries. The lexicon can serve as a tool for texture evaluation for correlating descriptive data, consumer preferences and conduct studies with same standards applicable to wide range of products.
Clinical and diagnostic evaluation of intraocular expulsion of a corneal epithelial inclusion cyst in a dog
Authors: Heller Amanda R. , DiFazio Matthew R. , Espinheira Gomes Filipe , Ledbetter Eric C. 
Published: April 2019

AbstractCase description: An 8‐year‐old spayed female mixed‐breed dog was presented for evaluation of an axial, raised, vascularized, lightly pigmented 3 mm diameter corneal lesion affecting the left eye (OS) that was present since adoption three years prior to presentation. The presumed cyst ruptured into the anterior chamber 5 months following initial presentation with progressive extrusion of intralesional contents into the anterior chamber. High‐frequency ultrasound and in vivo confocal microscopy revealed minimal normal stroma posterior to the corneal lesion. Due to the lack of stroma, a deep anterior lamellar keratoplasty (DALK) was attempted using the viscodissection technique. While separating the stroma from Descemet's membrane, a tear in the membrane was observed, and the procedure was converted to a penetrating keratoplasty (PK). The mass was excised en bloc, and a frozen corneal allograft and conjunctival pedicle graft were utilized to restore corneal thickness. The extruded material was irrigated out of the anterior chamber and submitted for culture and cytology. There was no growth on aerobic, anaerobic, or fungal cultures, and cytology revealed mixed neutrophilic and macrophagic inflammation with keratinizing squamous epithelium. Histopathology identified the mass to be a corneal epithelial inclusion cyst lined with well‐differentiated stratified squamous epithelium. The dog is doing well 10 months post‐operatively with no signs of recurrence along with good comfort and vision.
Dissection Versus Incubation: The Within-Subject Effects of Product Dissection Activities on Design Variety
Authors: Starkey Elizabeth M. , Alzayed Mohammad Alsager , Hunter Samuel , Miller Scarlett R. 
Published: April 2019

AbstractProduct dissection is a popular educational tool in engineering design due to its ability to help students understand a product, provide inspiration for new design ideas, and aid in product redesign. While prior research has investigated how dissecting a product before idea generation impacts the creative output of the ideation session, these studies failed to look at the types of ideas generated before dissection or how the type of product dissected impacts this. Thus, the goal of the current study was to examine how product dissection impacts the solution space explored by students. Fifty-five undergraduate engineering students participated in the experiment; 40 participants virtually dissected a product, while the remaining 15 completed a personality test. The results of the study highlight that students explored new types of ideas during the second ideation session for all conditions and at all levels, with students having the biggest increase in embodiment variety when they dissected analogically far products. Overall, there were no differences in design variety between students in the dissection condition and the incubation condition. This study highlights how incubation can impact design variety and calls for further investigation of the interaction between product dissection and incubation.
Performance Analyses and Evaluation of Co2 and N2 as Coolants in a Recuperated Brayton Gas Turbine Cycle for a Generation IV Nuclear Reactor Power Plant
Authors: Osigwe Emmanuel O. , Gad-Briggs Arnold , Nikolaidis Theoklis , Pilidis Pericles , Sampath Suresh 
Published: April 2019

Abstract
As demands for clean and sustainable energy renew interests in nuclear power to meet future energy demands, generation IV nuclear reactors are seen as having the potential to provide the improvements required for nuclear power generation. However, for their benefits to be fully realized, it is important to explore the performance of the reactors when coupled to different configurations of closed-cycle gas turbine power conversion systems. The configurations provide variation in performance due to different working fluids over a range of operating pressures and temperatures. The objective of this paper is to undertake analyses at the design and off-design conditions in combination with a recuperated closed-cycle gas turbine and comparing the influence of carbon dioxide and nitrogen as the working fluid in the cycle. The analysis is demonstrated using an in-house tool, which was developed by the authors. The results show that the choice of working fluid controls the range of cycle operating pressures, temperatures, and overall performance of the power plant due to the thermodynamic and heat properties of the fluids. The performance results favored the nitrogen working fluid over CO2 due to the behavior CO2 below its critical conditions. The analyses intend to aid the development of cycles for generation IV nuclear power plants (NPPs) specifically gas-cooled fast reactors (GFRs) and very high-temperature reactors (VHTRs).
Repeatability of choroidal thickness measurements with Spectralis OCT images
Authors: Lau Jason K , Cheung Sin Wan , Collins Michael J , Cho Pauline 
Published: April 2019

ObjectiveTo investigate the repeatability of choroidal thickness measurements determined from enhanced depth imaging optical coherence tomography (EDI-OCT) images of eyes after wearing single-vision spectacles (SV) and orthokeratology (ortho-k) lenses.Methods and analysisTwo EDI-OCT images of 40 children (SV: 20, ortho-k: 20) taken at a single visit were analysed twice. Subjects in the ortho-k group had been wearing ortho-k for 1–4 weeks. The choroidal thickness was determined from each image using a graph theory-based software and, where appropriate, manual correction of choroidal boundaries was undertaken by an experienced examiner.ResultsThe mean (±SD) choroidal thickness was 227.3±42.2 µm for the SV subjects and 251.1±54.4 µm for the ortho-k subjects. The interimage differences in choroidal thickness were −0.99±3.54 and −1.14±5.03 µm for the SV and ortho-k subjects, respectively, and the limits of agreement were +5.96 to −7.93 and +8.72 to −11.00 µm, respectively.ConclusionThe coefficients of repeatability of choroidal thickness measurements from two EDI-OCT images taken at a single visit were 7.08 µm (SV) and 10.06 µm (ortho-k), suggesting that a change in choroidal thickness of less than 10 µm may not indicate a real change resulting from ortho-k lens wear.
The Physics of Cancer
Authors: White Forest M. , Gatenby Robert A. , Fischbach Claudia 
Published: April 2019

Abstract
While often described as a “disease of the genes,” cancer is, in fact, a complex dynamic system in which evolving cells both affect and are affected by the physical properties of their environment. About 10 years ago, after a number of multidisciplinary workshops and meetings, the NCI leadership embarked on a bold program to systematically integrate physical sciences into cancer biology and treatment through formation of the Physical Sciences-Oncology Network (PS-ON). Here, we highlight key areas in which the two disciplines have been successfully integrated and lessons learned from the first decade of the PS-ON experiment.
Mogamulizumab Treatment Elicits Autoantibodies Attacking the Skin in Patients with Adult T-Cell Leukemia-Lymphoma
Authors: Suzuki Yui , Saito Masato , Ishii Toshihiko , Urakawa Itaru , Matsumoto Asuka , Masaki Ayako , Ito Asahi , Kusumoto Shigeru , Suzuki Susumu , Hiura Masanori , Takahashi Takeshi , Morita Akimichi , Inagaki Hiroshi , Iida Shinsuke , Ishida Takashi 
Published: April 2019

Abstract

Purpose:
The anti-CCR4 mAb, mogamulizumab, offers therapeutic benefit to patients with adult T-cell leukemia-lymphoma (ATL), but skin-related adverse events (AE) such as erythema multiforme occur frequently. The purpose of this study was to determine the mechanisms by which mogamulizumab causes skin-related AEs in patients with ATL.

Experimental Design:
We investigated whether autoantibodies were present in patients’ sera using flow cytometry to determine binding to keratinocytes and melanocytes (n = 17), and immunofluorescence analysis of tissue sections. We analyzed the IgM heavy chain repertoire in peripheral blood mononuclear cells before and after mogamulizumab or other chemotherapy by next-generation sequencing (NGS; n = 16).

Results:
Autoantibodies recognizing human keratinocytes or melanocytes were found in the sera of 6 of 8 patients suffering from mogamulizumab-induced erythema multiforme. In one patient, complement-dependent cytotoxicity (CDC) mediated by autoantibodies against keratinocytes or melanocytes was proportionally related to the severity of the erythema multiforme. The presence of autoantibodies in the epidermis was confirmed in all biopsy specimens of mogamulizumab-induced erythema multiforme (n = 12). Furthermore, colocalization of autoantibodies and C1q, suggesting the activation of CDC, was observed in 67% (8/12). In contrast, no autoantibody or C1q was found in ATL tumor skin lesions (n = 13). Consistent with these findings, NGS demonstrated that IgM germline genes had newly emerged and expanded, resulting in IgM repertoire skewing at the time of erythema multiforme.

Conclusions:
Mogamulizumab elicits autoantibodies playing an important role in skin-related AEs, possibly associated with regulatory T-cell depletion. This is the first report demonstrating the presence of skin-directed autoantibodies after mogamulizumab treatment.
Impact of a Pre-Operative Exercise Intervention on Breast Cancer Proliferation and Gene Expression: Results from the Pre-Operative Health and Body (PreHAB) Study
Authors: Ligibel Jennifer A. , Dillon Deborah , Giobbie-Hurder Anita , McTiernan Anne , Frank Elizabeth , Cornwell MacIntosh , Pun Matthew , Campbell Nancy , Dowling Ryan J.O. , Chang Martin C. , Tolaney Sara , Chagpar Anees B. , Yung Rachel L. , Freedman Rachel A. , Dominici Laura S. , Golshan Mehra , Rhei Esther , Taneja Krishan , Huang Ying , Brown Myles , Winer Eric P. , Jeselsohn Rinath , Irwin Melinda L. 
Published: April 2019

Abstract

Purpose:
Exercise after breast cancer diagnosis is associated with lower cancer-specific mortality, but the biological mechanisms through which exercise impacts breast cancer are not fully understood. The Pre-Operative Health and Body (PreHAB) Study was a randomized window-of-opportunity trial designed to test the impact of exercise on Ki-67, gene expression, and other biomarkers in women with breast cancer.

Experimental Design:
Inactive women with newly diagnosed breast cancer were randomized to an exercise intervention or mind–body control group, and participated in the study between enrollment and surgery (mean 29.3 days). Tumor and serum were collected at baseline and surgery.

Results:
Forty-nine women were randomized (27 exercise, 22 control). At baseline, mean age was 52.6, body mass index was 30.2 kg/m2, and exercise was 49 minutes/week. Exercise participants significantly increased exercise versus controls (203 vs. 23 minutes/week, P &lt; 0.0001). There were no differences in changes of expression of Ki-67, insulin receptor, and cleaved caspase-3 in exercise participants versus controls. KEGG pathway analysis demonstrated significant upregulation of 18 unique pathways between the baseline biopsy and surgical excision in exercise participants and none in control participants (q &lt; 0.1). Top-ranked pathways included several implicated in immunity and inflammation. Exploratory analysis of tumor immune infiltrates demonstrated a trend toward a decrease in FOXP3+ cells in exercise versus control participants over the intervention period (P = 0.08).

Conclusions:
A window-of-opportunity exercise intervention did not impact proliferation but led to alterations in gene expression in breast tumors, suggesting that exercise may have a direct effect on breast cancer.
See related commentary by Koelwyn and Jones, p. 5179