bluuebunny/crossref_metadata_2025_split huggingface dataset:
The effect of intrinsic and extrinsic goals on work performance
Authors: Zhang Ying , Zhang Jian , Li Jingjing 
Published: May 2018

PurposeBased on the goal content theory (GCT), the purpose of this paper is to focus on the essence of goals and examine the associations between different work goal contents (intrinsic and extrinsic goals) and work performance.Design/methodology/approachThe data were collected from 279 employees and their immediate supervisors, and the theoretical hypotheses were tested by correlation and hierarchal regression analyses.FindingsThe results of the analyses showed that intrinsic goal content positively predicted task performance, dedicative performance, interpersonal performance, and adaptive performance and that extrinsic goal content positively predicted the task performance and adaptive performance; intrinsic goals were also found to enhance the relationship between extrinsic goals and task performance.Originality/valueThe contribution of the current study is that it explores whether both extrinsic goals and intrinsic goals can contribute to predicting work performance. Moreover, different from previous studies that focus on discussing the separate effects of intrinsic and extrinsic goals on outcomes, the authors aim to study the interaction effect between these goals, which enriches GCT.
Graduate student writing: Complexity in literature reviews
Authors: Badenhorst Cecile M. 
Published: May 2018

PurposeThe purpose of this study is to explore Master’s students’ literature reviews to better understand the literacies required for engaging in complexity in this genre and to inform graduate student pedagogy.Design/methodology/approachIn this qualitative study, data were collected in the form of student literature review papers (23 drafts and 23 final versions) from students attending a research seminar course in an all-course Master’s program. All papers were analyzed for citations patterns, genre awareness and levels of complexity.FindingsResults highlight the nature of complexity in this genre – that this complexity is underpinned by discursive issues such as “truth”, “claims” or “facts” that often mislead novice academic writers, and recognizing that knowledge contested in academic contexts is important to understanding and teaching students about complexity in writing.Originality/valueOne of the most challenging writing tasks graduate students face, is the literature review. Literature reviews require sophisticated conceptual maneuverings. Despite being analytical in nature, many students find it difficult to engage with the layers of complexity required in this genre. How do we make the complexity in literature reviews more visible and accessible? The argument in this paper is that understanding the nature of complexity in literature reviews can enhance writing processes and intentional explicit pedagogy.
The strange case of dating apps at a gay resort: hyper-local and virtual-physical leisure
Authors: Vorobjovas-Pinta Oskaras , Dalla-Fontana Isaac Jonathan 
Published: May 2018

PurposeThe purpose of this paper is to report novel information about the use of gay apps by the patrons of an exclusively gay resort in Queensland, Australia. This novel research environment facilitates an understanding of the embeddedness of gay dating apps within contemporary gay culture and community and the spatial reorientation that comes alongside the juxtaposition of physical and digital geographies.Design/methodology/approachAn ethnographic study was conducted at the resort, and qualitative data presented here are drawn from semi-structured interviews with 27 gay-identifying male patrons of the resort. Critical ethnography provided beneficial access to situated perspectives and realities.FindingsThese data indicate that gay apps remain a pervasive way of making connections, even in an environment where common homosexuality is a reasonable expectation and where open self-expression is permitted and even encouraged. This complicates assumptions that gay apps’ emergence was in response to a need for privacy or anonymity for lesbian, gay, bisexual and transgender (LGBT) people in wider, straight society.Originality/valueThis paper reports the results of an ethnographic survey conducted in a highly novel research environment and particularly seeks to address divergent experiences of social and cultural change by LGBT people, including generational divides. It has value in demonstrating clear differences, ambiguities and mixed implications of gay apps and their relationship with changing LGBT spaces.
Degradation of amyloid β peptide by neprilysin expressed from Borna disease virus vector
Authors: Sakai Madoka , Ueda Sakiho , Daito Takuji , Asada‐Utsugi Megumi , Komatsu Yumiko , Kinoshita Ayae , Maki Takakuni , Kuzuya Akira , Takahashi Ryosuke , Makino Akiko , Tomonaga Keizo 
Published: May 2018

ABSTRACTAccumulation of amyloid β (Aβ40 and Aβ42) in the brain is a characteristic of Alzheimer disease (AD). Because neprilysin (NEP) is a major Aβ‐degrading enzyme, NEP delivery in the brain is a promising gene therapy for AD. Borna disease virus (BoDV) vector enables long‐term transduction of foreign genes in the central nerve system. Here, the proteolytic ability of NEP transduced by the BoDV vector was evaluated and it was found that the amounts of Aβ40 and Aβ42 decreased significantly, suggesting that NEP expressed from the BoDV vector is functional in that it degrades Aβ.
‘If I can walk that far’: space and embodiment in stories of illness and recovery
Authors: Heavey Emily 
Published: May 2018

AbstractIllness and recovery transform embodied experience, and transform the experience of space. Space, in turn, is a valuable resource in the telling of an illness narrative. Starting from a phenomenological perspective that takes the body to be the centre of experience, and hence of selfhood and storytelling, this article offers an argument for and an approach to analysing space as a narrative resource in stories about illness and recovery. Using a case study of one woman's stories about her amputation, it demonstrates how both narrated space and narrating space can be used as devices to structure the narrative and position its characters and interlocutors to construct the narrator's embodied experiences and identities. The article reveals intersections between embodied experience, space, and narrative identity construction, offering a new way of attending to illness narratives and a new way of engaging with narrative space.
Retracted: The heterogeneous effect of diversity: Ascriptive identities, class and redistribution in developed democracies
Authors: YAKTER ALON 
Published: May 2018

AbstractRetraction Statement: Alon Yakter, The heterogeneous effect of diversity: Ascriptive identities, class and redistribution in developed democracies, European Journal of Political Research 2019, 58(1), 12283 (https://ejpr.onlinelibrary.wiley.com/doi/10.1111/1475-6765.12283). The above article, published online on 17 May 2018 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the journal Editor in Chief Emiliano Grossman, and John Wiley & Sons Ltd. This action has been agreed due to an error at the publishers which caused a duplicate of the article to be published on 8 February 2019. The correct version of the article is to be found at: ‘The heterogeneous effect of diversity: Ascriptive identities, class and redistribution in developed democracies’ by Alon Yakter (https://doi.org/10.1111/1475-6765.12315).
The reverse remodeling response to sacubitril/valsartan therapy in heart failure with reduced ejection fraction
Authors: Martens Pieter , Beliën Hanne , Dupont Matthias , Vandervoort Pieter , Mullens Wilfried 
Published: May 2018

SummaryBackgroundMajor classes of medical therapy for heart failure with reduced ejection fraction (HFrEF) induce reverse remodeling. The revere remodeling response to sacubitril/valsartan remains unstudied.MethodsWe performed a single‐center, prospective assessor‐blinded study to determine the reverse remodeling response of sacubitril/valsartan therapy in HFrEF patients with a class I indication (New York heart Association [NYHA]‐class II‐IV, Left ventricular ejection fraction [LVEF] < 35%, optimal dose with Renin‐Angiotensin‐System‐Blocker [RAS‐blocker]). Doses of sacubitril/valsartan were optimized to individual tolerance. Echocardiographic images were assessed offline by 2 investigators blinded to both the clinical data and timing of echocardiograms.ResultsOne‐hundred‐twenty‐five HFrEF patients (66 ± 10 years) were prospectively included. The amount of RAS‐blocker before and after switch to sacubitril/valsartan was similar(P = .290), indicating individual optimal dosing of sacubitril/valsartan. Over a median(IQR) follow‐up of 118(77‐160) days after initiation of sacubitril/valsartan, LVEF improved (29.6 ± 6% vs 34.8 ± 6%; P < .001) and Left ventricular end‐systolic (LVESV) and end‐diastolic volume (LVEDV) decreased (LVESV; 147 ± 57 mL vs 129 ± 55 mL; P < .001 and LVEDV; 206 ± 71 mL vs197 ± 72 mL; P = .027). Volumetric remodeling was associated with a reduction in the degree of mitral regurgitation (1.59 ± 1.0 vs 1.11 ± 0.8; P < .001; [scale from 0‐4]). Metrics of diastolic function improved; including a drop in the E/A‐wave ratio (1.75 ± 1.13 vs 1.38 ± 0.88; P = .002) and diastolic filling time (% of cycle length) prolonged (48 ± 9% vs 52 ± 1%; P = .005). The percent of patients with a restrictive mitral filling pattern dropped from 47% to 23% (P = .004). A dose‐dependent effect was noted for changes in LVEF (P < .001) and LVESV (P = .031), with higher doses of sacubitril/valsartan leading to more reverse remodeling.ConclusionSwitching therapy in eligible HFrEF patients from a RAS‐blocker to sacubitril/valsartan induces beneficial reverse remodeling of both metrics of systolic as diastolic function.
Pregnancy, parity and periodontal disease
Authors: Morelli EL , Broadbent JM , Leichter JW , Thomson WM 
Published: May 2018

AbstractMany women believe that their dental condition deteriorated during pregnancy or as a result of having children. Epidemiological studies have reported an association between higher parity and tooth loss, and higher parity and periodontal attachment loss. Several possible explanations for this association exist. First, hormonal changes during pregnancy affect the immune response to bacterial plaque and drive vascular and gingival changes that may contribute to heightened gingival inflammation. These changes are transient, without irreversible loss of periodontal attachment, and post‐partum resolution can be expected for most women. For women with destructive periodontal disease, the effects of pregnancy and parity are unclear. Second, it is also plausible that parity and socioeconomic position (SEP) have shared risk factors, increasing the incidence of disease or influencing its management. Education, one aspect of SEP, is an important determining factor for women's fertility rate, with a gradient of fewer children with higher educational attainment. Higher levels of education are also favourably associated with behaviours conducive to oral health, and a lower incidence of damaging health behaviours. Thus, the potential for confounding is considerable. This review examines the literature on the association between pregnancy, parity and periodontal health, and explores sociobehavioural mechanisms for the observed association.
Looking into the eye of patients with chronic obstructive pulmonary disease: an opportunity for better microvascular profiling of these complex patients
Authors: Vaes Anouk W. , Spruit Martijn A. , Theunis Jan , Goswami Nandu , Vanfleteren Lowie E. , Franssen Frits M.E. , Wouters Emiel F.M. , De Boever Patrick 
Published: May 2018

AbstractChronic obstructive pulmonary disease (COPD) is a complex disease with many patients suffering from cardiovascular comorbidity. However, cardiovascular diseases remain often undiagnosed in COPD. Assessment of the retinal microvasculature can provide value in cardiovascular profiling of these patients. Retinal microvascular assessment carried out via a noninvasive eye exam represents an easy to use tool when examining patients with COPD. The purpose of this review was to provide an overview of studies assessing structural and functional changes in the retinal microvasculature of patients with COPD. Findings demonstrated that structural and functional microvascular changes were more common and severe in COPD patients as compared to non‐COPD controls, although few retinal investigations have been performed in patients with COPD. As cardiovascular comorbidities are highly prevalent in COPD, we advocate more research to investigate the value of an eye exam for microvascular phenotyping of COPD patients.
Umbilical resection during laparoscopic surgery for urachal remnants
Authors: Maemoto Ryo , Matsuo Susumu , Sugimoto Shinichi , Tokuka Atsuo 
Published: May 2018

AbstractIntroductionBecause urachal remnants are rare, no standard therapeutic guidelines have been established for this lesion. In recent years, laparoscopic surgery (LS) has been performed by many surgeons and urologists to treat urachal remnants. The prevention of postoperative umbilical infection and late malignant transformation are major issues in the treatment of urachal remnants. Adequate resection of the urachal epithelial tissue is required, and therefore, umbilical resection (UR) is performed. We retrospectively assessed the feasibility of this modality for urachal remnants by examining cases we have experienced as well as 210 Japanese surgical cases found through literature review.MethodsFrom January 1998 to March 2016, we experienced 14 operative cases of urachal remnants who underwent LS at Shimane Prefectural Central Hospital. We examined the types of urachal remnants and patients’ ages, symptoms, surgical methods, and pathological findings.ResultsWe performed UR in 6 of these 14 LS patients to achieve appropriate resection of the urachal epithelial tissue. The main indication for UR was a long history of preoperative therapies for umbilical infection. The average observation period after the operation was 3.95 years, and no patients developed recurrent umbilical infection or cancer. No patients complained about the aesthetic outcome after umbilicoplasty.ConclusionWe recommend that UR with LS be performed for urachal remnants to prevent any recurrent umbilical infection or malignant transformation in the future.
Vitrification for bovine embryos with low‐quality grade
Authors: Tajimi Hiroshi , Yamazaki Tsugumi , Oike Syoko , Yoshida Tatsuyuki , Okada Konosuke , Kuwayama Masashige , Ushijima Hitoshi 
Published: May 2018

AbstractThis study was conducted to examine the utility of vitrification for bovine embryos with low‐quality grade, and simple cryoprotectants dilution method for practitioners. In Experiment 1, survival of frozen embryos was compared with that of vitrified embryos using minimum volume cooling (MVC). Then, vitrified embryos were used to confirm the optimum sucrose concentration in Experiment 2. The survival rates of embryos that had been vitrified following diluted cryoprotectants with the one‐step in‐straw method were compared with those of fresh control embryos in Experiment 3. Frozen‐thawed or vitrified‐warmed blastocysts were cultured with TCM‐199 supplemented with 100 μmol/L beta‐mercaptoethanol +5% fetal bovine serum at 38.5°C in an atmosphere of 5% CO2 in air, their survival after 24 hr were compared. The development to term of fair quality in vivo embryos after vitrification was examined in Experiment 4. Results show that survival rates of frozen‐thawed embryos were lower (p < .05) than that of vitrified‐warmed ones. When vitrified embryos were warmed in 0.3 mol/L sucrose in straws, their survival rate was 100%. The total cell numbers of vitrified‐warmed embryos were comparable to those of fresh control embryos. The six calves from 13 vitrified embryos were delivered in Experiment 4. These results indicate that MVC vitrification following one‐step cryoprotectants dilution is utilized to preserve low‐quality bovine embryos.
Semi-Parametric Methods of Handling Missing Data in Mortal Cohorts Under Non-Ignorable Missingness
Authors: Wen Lan , Seaman Shaun R. 
Published: May 2018

Summary
We propose semi-parametric methods to model cohort data where repeated outcomes may be missing due to death and non-ignorable dropout. Our focus is to obtain inference about the cohort composed of those who are still alive at any time point (partly conditional inference). We propose: i) an inverse probability weighted method that upweights observed subjects to represent subjects who are still alive but are not observed; ii) an outcome regression method that replaces missing outcomes of subjects who are alive with their conditional mean outcomes given past observed data; and iii) an augmented inverse probability method that combines the previous two methods and is double robust against model misspecification. These methods are described for both monotone and non-monotone missing data patterns, and are applied to a cohort of elderly adults from the Health and Retirement Study. Sensitivity analysis to departures from the assumption that missingness at some visit t is independent of the outcome at visit t given past observed data and time of death is used in the data application.
Detection of Multiple Perturbations in Multi-Omics Biological Networks
Authors: Griffin Paula J. , Zhang Yuqing , Johnson William Evan , Kolaczyk Eric D. 
Published: May 2018

Summary
Cellular mechanism-of-action is of fundamental concern in many biological studies. It is of particular interest for identifying the cause of disease and learning the way in which treatments act against disease. However, pinpointing such mechanisms is difficult, due to the fact that small perturbations to the cell can have wide-ranging downstream effects. Given a snapshot of cellular activity, it can be challenging to tell where a disturbance originated. The presence of an ever-greater variety of high-throughput biological data offers an opportunity to examine cellular behavior from multiple angles, but also presents the statistical challenge of how to effectively analyze data from multiple sources. In this setting, we propose a method for mechanism-of-action inference by extending network filtering to multi-attribute data. We first estimate a joint Gaussian graphical model across multiple data types using penalized regression and filter for network effects. We then apply a set of likelihood ratio tests to identify the most likely site of the original perturbation. In addition, we propose a conditional testing procedure to allow for detection of multiple perturbations. We demonstrate this methodology on paired gene expression and methylation data from The Cancer Genome Atlas (TCGA).
How can we expand active surveillance criteria in patients with low‐ and intermediate‐risk prostate cancer without increasing the risk of misclassification? Development of a novel risk calculator
Authors: Gandaglia Giorgio , van den Bergh Roderick C.N. , Tilki Derya , Fossati Nicola , Ost Piet , Surcel Christian I. , Sooriakumaran Prasanna , Tsaur Igor , Valerio Massimo , Kretschmer Alexander , Zaffuto Emanuele , Salomon Laurent , Montorsi Francesco , Graefen Markus , van der Poel Henk , de la Taille Alexandre , Briganti Alberto , Ploussard Guillaume ,   the European Association of Urology Young Academic Urologists Working Party on Prostate Cancer (EAU‐YAUWP)
Published: May 2018

ObjectiveTo develop a novel tool to increase the number of patients with prostate cancer eligible for active surveillance (AS) without increasing the risk of unfavourable pathological features (i.e., misclassification) at radical prostatectomy (RP).Patients and MethodsOverall, 16 049 patients with low‐ or intermediate‐risk prostate cancer treated with RP were identified. Misclassification was defined as non‐organ confined or grade group ≥3 disease at RP. The coefficients of a logistic regression model predicting misclassification were used to develop a risk score. We then performed a systematic analysis of different thresholds to discriminate between patients with or without unfavourable disease and we compared it to available AS criteria.ResultsOverall, 5289 (33.0%) patients had unfavourable disease. At multivariable analyses, PSA level, clinical stage, biopsy grade group, the number of positive cores, and PSA density were associated with the risk of unfavourable disease (all P < 0.001). The Prostate Cancer Research International: Active Surveillance (PRIAS) criteria were associated with a lower risk of misclassification (13%) compared to other criteria. Overall, 3303 (20.6%) patients were eligible according to the PRIAS protocol. The adoption of an 18% threshold according to the risk score increased the proportion of eligible patients from 20.6% to 29.4% without increasing the risk of misclassification as compared to the PRIAS criteria.ConclusionsThe use of a novel risk score for AS selection would result in an absolute increase of 10% in the number of patients eligible for this approach without increasing the risk of misclassification.
Usefulness of real‐time three‐dimensional ultrasonography in percutaneous nephrostomy: an animal study
Authors: Hongzhang Hong , Xiaojuan Qin , Shengwei Zhang , Feixiang Xiang , Yujie Xu , Haibing Xiao , Gallina Kazobinka , Wen Ju , Fuqing Zeng , Xiaoping Zhang , Mingyue Ding , Huageng Liang , Xuming Zhang 
Published: May 2018

ObjectivesTo evaluate the effect of real‐time three‐dimensional (3D) ultrasonography (US) in guiding percutaneous nephrostomy (PCN).Materials and MethodsA hydronephrosis model was devised in which the ureters of 16 beagles were obstructed. The beagles were divided equally into groups 1 and 2. In group 1, the PCN was performed using real‐time 3D US guidance, while in group 2 the PCN was guided using two‐dimensional (2D) US. Visualization of the needle tract, length of puncture time and number of puncture times were recorded for the two groups.ResultsIn group 1, score for visualization of the needle tract, length of puncture time and number of puncture times were 3, 7.3 ± 3.1 s and one time, respectively. In group 2, the respective results were 1.4 ± 0.5, 21.4 ± 5.8 s and 2.1 ± 0.6 times. The visualization of needle tract in group 1 was superior to that in group 2, and length of puncture time and number of puncture times were both lower in group 1 than in group 2.ConclusionsReal‐time 3D US‐guided PCN is superior to 2D US‐guided PCN in terms of visualization of needle tract and the targeted pelvicalyceal system, leading to quick puncture. Real‐time 3D US‐guided puncture of the kidney holds great promise for clinical implementation in PCN.
Extending the scope of amantadine drug by incorporation of phenolic azo Schiff bases as potent selective inhibitors of carbonic anhydrase II, drug‐likeness and binding analysis
Authors: Channar Pervaiz A. , Saeed Aamer , Shahzad Danish , Larik Fayaz Ali , Hassan Mubashir , Raza Hussain , Abbas Qamar , Seo Sung‐Yum 
Published: May 2018

A series of Amantadine‐based azo Schiff base dyes 6a–6e have been synthesized and characterized by 1H NMR and 13C NMR and evaluated for their in vitro carbonic anhydrase II inhibition activity and antioxidant activity. All of the synthesized showed excellent carbonic inhibition. Compound 6b was found to be the most potent derivative in the series, and the IC50 of 6b was found to be 0.0849 ± 0.00245 μm (standard Acetazolamide IC50 = 0.9975 ± 0.049 μm). The binding interactions of the most active analogs were confirmed through molecular docking studies. Docking studies showed 6b is interacting by making two hydrogen bonds w at His93 and Ser1 residues, respectively. All compounds showed a good drug score and followed Lipinski's rule. In summary, our studies have shown that these amantadine‐derived phenolic azo Schiff base derivatives are a new class of carbonic anhydrase II inhibitors.