bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cryoprecipitate Usage and Cost at a Tertiary Care Hospital Between 2010 and 2017
Authors: Serei Virian , Wong Cecilia , Tenorio Grace 
Published: September 2019

Abstract

Introduction
Cryoprecipitate (CRYO), a blood product prepared from FFP, is rich in fibrinogen, von Willebrand’s factor, and factors VIII and XIII. ​The major indication for CRYO transfusion is fibrinogen deficiency with increased risk of bleeding when fibrinogen is <100 mg/dL, a transfusion trigger rarely followed by the house staff or other clinicians. To limit wastage, Transfusion Services issue them as pools of five individual CRYO units. The use of CRYO at Robert Wood Johnson University Hospital (RWJUH) has significantly risen since 2010, so we conducted a study to identify the factors leading to increased CRYO transfusions.

Methods
Data on CRYO transfusions from 2010 to 2017 were obtained and analyzed for trends in overall usage and by nursing unit/departments. Cost-analysis was performed to determine the cost of CRYO usage.

Conclusion
Overall, CRYO usage has risen since 2010, with a sharp increase between 2015 and 2017 attributed to increased transfusions in the operating room (OR), surgical intensive care unit, and hematology-oncology units. There was a sixfold rise in transfusions in the hematology-oncology units. During this time, the lower limit of the fibrinogen reference range decreased from 234 to 190 mg/dL along with a drop in the number of trauma alerts. Values less than the lower reference range were used as the transfusion trigger by some overzealous hematology fellows. Cost-analysis showed that RWJUH lost 75% revenue per patient based on Medicare reimbursement despite efforts to limit wastage and lowering purchasing cost per unit by changing to a new blood supplier. The major determinants of intensified CRYO transfusions at RWJUH are (1) changes in the fibrinogen reference range concomitant with enhanced awareness, monitoring, and early treatment of hypofibrinogenemia, particularly in hematology-oncology units and (2) the complexity of surgical procedures (ie, VAD procedures) requiring more CRYO transfusions rather than the number of trauma alerts.
Correlating Transfusion Medicine In-Service Examination Scores With Outcomes of the American Board of Pathology Transfusion Medicine Subspecialty Certifying Examination
Authors: Peedin Alexis R , Genzen Jonathan R , Karp Julie K 
Published: September 2019

Abstract

Objectives
The Transfusion Medicine In-Service Examination (TMISE) is offered twice a year to transfusion medicine (TM) fellows. We examined the relationship between TMISE scores and outcomes of the American Board of Pathology (ABP) TM subspecialty certifying examination (TM boards).

Methods
TM fellowship programs were contacted to provide anonymous data about TM fellows, their scores on TMISE, and outcome of TM boards.

Results
Of 48 TM fellowship programs contacted, 24 (50%) responded with data for 170 fellows. Average TMISE score of fellows who passed their first TM boards attempt was 71.3, while the average TMISE score of fellows who failed their first TM boards attempt was 64.3 (P = .009).

Conclusions
TMISE scores correlated with passing TM boards on the first attempt. Fellows who took the TM boards the same year that they graduated from TM fellowship had a significantly higher first-time pass rate than fellows who delayed taking TM boards.
An Exploration of the Impact of Non-Dependent Parental Drinking on Children
Authors: Bryant Lucy , MacKintosh Anne Marie , Bauld Linda 
Published: September 2019

ABSTRACT

Aims
To examine the impact of non-dependent parental drinking on UK children aged 10–17.

Methods
Cross-sectional survey of UK parents and their children in 2017 (administered to one parent in a household, then their child, totaling 997 adults and 997 children), providing linked data on parental drinking from parent and child perspectives. The survey included measures of parents’ alcohol consumption and drinking motivations (both reported by parents) and children’s exposure to their parent’s drinking patterns and children’s experiences of negative outcomes following their parent’s drinking (both reported by children), plus sociodemographic measures.

Results
Logistic regression analysis indicates a significant positive association between parental consumption level and children reporting experiencing negative outcomes. Witnessing a parent tipsy or drunk and having a parent who reported predominantly negative drinking motives were also associated with increased likelihood of children reporting experiencing negative outcomes. Age was also associated, with older children less likely to report experiencing negative outcomes following their parent’s drinking.

Conclusions
Findings suggest levels of and motivations for parental drinking, as well as exposure to a parent tipsy or drunk, all influence children’s likelihood of experiencing negative outcomes.
A novel molecular representation with BiGRU neural networks for learning atom
Authors: Lin Xuan , Quan Zhe , Wang Zhi-Jie , Huang Huang , Zeng Xiangxiang 
Published: September 2019

Abstract
Molecular representations play critical roles in researching drug design and properties, and effective methods are beneficial to assisting in the calculation of molecules and solving related problem in drug discovery. In previous years, most of the traditional molecular representations are based on hand-crafted features and rely heavily on biological experimentations, which are often costly and time consuming. However, recent researches achieve promising results using machine learning on various domains. In this article, we present a novel method named Smi2Vec-BiGRU that is designed for learning atoms and solving the single- and multitask binary classification problems in the field of drug discovery, which are the basic and also key problems in this field. Specifically, our approach transforms the molecule data in the SMILES format into a set of sample vectors and then feeds them into the bidirectional gated recurrent unit neural networks for training, which learns low-dimensional vector representations for molecular drug. We conduct extensive experiments on several widely used benchmarks including Tox21, SIDER and ClinTox. The experimental results show that our approach can achieve state-of-the-art performance on these benchmarking datasets, demonstrating the feasibility and competitiveness of our proposed approach.
Regional Variation of Bitter Taste and Aftertaste in Humans
Authors: Higgins Molly J , Hayes John E 
Published: September 2019

Abstract
Despite widespread and persistent myths of a tongue map, all 5 prototypical taste qualities are sensed over the entire tongue. However, modern psychophysical data also suggest there may be more nuanced differences in suprathreshold intensity across oral loci, especially for bitterness. Here, we test whether bitter stimuli matched for whole-mouth intensity differ in perceived intensity across regions of the oral cavity in 2 experiments. Experiment 1 consisted of a whole-mouth sip and spit approach and Experiment 2 consisted of a spatial taste test using cotton swabs. In Experiment 1, participants (n = 63) rated overall intensity of 3 bitter solutions at 5 different loci (front, middle, back of tongue; roof of mouth; and lip). Temporal effects were explored using in-mouth and aftertaste ratings. In Experiment 2, participants (n = 48) rated the intensity of quinine and Tetralone solutions after solutions were painted on fungiform, circumvallate, and foliate papillae with a swab. After the spatial taste test, participants completed a questionnaire on self-reported beer intake. Analysis of variance results of both experiments show a significant locus by stimulus interaction, suggesting different bitterants were perceived differently across the various loci. This result was apparently driven by low-intensity ratings for Tetralone on the anterior tongue. Aftertaste ratings in Experiment 1 also revealed significant temporal effects: ratings on the anterior tongue decreased for all bitterants and ratings for quinine decreased at all loci. Reasons for these effects are not known but may suggest differential expression of bitter taste receptors or differences in bitter agonist-receptor binding affinity across tongue regions.
Transcriptomic Analysis and High-dimensional Phenotypic Mapping of Mononuclear Phagocytes in Mesenteric Lymph Nodes Reveal Differences Between Ulcerative Colitis and Crohn’s Disease
Authors: Chapuy Laurence , Bsat Marwa , Rubio Manuel , Harvey François , Motta Vinicius , Schwenter Frank , Wassef Ramses , Richard Carole , Deslandres Colette , Nguyen Bich N , Soucy Geneviève , Hacohen Nir , Fritz Jorge , Villani Alexandra-Chloé , Mehta Heena , Sarfati Marika 
Published: September 2019

Abstract

Background and Aims
Crohn’s disease [CD] and ulcerative colitis [UC] are distinct forms of inflammatory bowel disease. Heterogeneity of HLA-DR+SIRPα + mononuclear phagocytes [MNPs], including macrophages [MΦ], monocyte-derived [Mono] cells, and dendritic cells [DCs], was reported in gut tissue but not yet investigated in mesenteric lymph nodes [MLNs] of IBD patients. We here compared the phenotype, function, and molecular profile of HLA-DR+SIRPα + MNPs in CD and UC MLNs.

Methods
Cell distribution, morphology, immune function, and transcriptomic [bulk RNAseq] and high-dimensional protein expression profiles [CyTOF] of HLA-DR+SIRPα + MNPs were examined in MLNs of UC [n = 14], CD [n = 35], and non-IBD [n = 12] patients.

Results
Elevated frequencies of CD14+CD64+CD163+ [Mono/MΦ-like] MNPs displaying monocyte/MΦ morphology and phagocytic function were a distinct feature of UC MLNs. In CD, the proportion of CD14-CD64-CD163- [DC-like] cells was augmented relative to Mono/MΦ-like cells; DC-like cells drove naïve T cell proliferation, Th1 polarisation, and Th17 TCM plasticity. Gene expression profile corroborated the nature of DC-like cells, best represented by BTLA, SERPINF, IGJ and, of Mono/MΦ-like cells, defined by CD163, MARCO, MAFB, CD300E, S100A9 expression. CyTOF analysis showed that CD123+ plasmacytoid cells predominated over conventional DCs in DC-like cells. Four CD163+ clusters were revealed in Mono/MΦ-like cells, two of which were enriched in MARCO-CD68dimHLA-DRdim monocyte-like cells and MARCOhiCD68hiHLA-DRhi Mɸ, whose proportion increased in UC relative to CD.

Conclusions
Defining the landscape of MNPs in MLNs provided evidence for expansion of CD163+ Mono/MΦ-like cells in UC only, highlighting a distinction between UC and CD, and thus the potential contribution of monocyte-like cells in driving colitis.
Non-pigmented rapidly growing mycobacteria smooth and rough colony phenotypes pathogenicity evaluated usingin vitroand experimental models
Authors: García-Coca Marta , Aguilera-Correa John-Jairo , Ibáñez-Apesteguía Arancha , Rodríguez-Sevilla Graciela , Romera-García David , Mahíllo-Fernández Ignacio , Reina Gabriel , Fernández-Alonso Mirian , Leiva José , Muñoz-Egea María-Carmen , Del Pozo José Luis , Esteban Jaime 
Published: September 2019

ABSTRACTNon-pigmented rapidly growing mycobacteria (NPRGM) are widely distributed in water, soil and animals. It has been observed an increasing importance of NPRGM related-infections, particularly due to the high antimicrobial resistance. NPRGM have rough and smooth colony phenotypes, and several studies have showed that rough colony variants are more virulent than smooth ones. However, other studies have failed to validate this observation. In this study, we have performed two models, invitro and in vivo, in order to assess the different pathogenicity of these two phenotypes. We used collection and clinical strains of Mycobacteriumabscessus, Mycobacterium fortuitum and Mycobacteriumchelonae. On the invitro model (macrophages), phagocytosis was higher for M. abscessus and M. fortuitum rough colony variant strains when compared to smooth colony variants. However, we did not find differences with colonial variants of M. chelonae. Survival of Galleriamellonella larvae in the experimental model was lower for M. abscessus and M. fortuitum rough colony variants when compared with larvae infected with smooth colony variants. We did not find differences in larvae infected with M. chelonae.Results of our in vivo study correlated well with the experimental model. This fact could have implications on the interpretation of the clinical significance of the NPRGM isolate colonial variants.
A Question of Norton–Sullivan in the Analytic Case
Authors: Wang Jian , Yang Hui 
Published: September 2019

Abstract
In 1996, A. Norton and D. Sullivan asked the following question: If $f:\mathbb{T}^2\rightarrow \mathbb{T}^2$ is a diffeomorphism, $h:\mathbb{T}^2\rightarrow \mathbb{T}^2$ is a continuous map homotopic to the identity, and $h f=T_{\rho } h$, where $\rho \in \mathbb{R}^2$ is a totally irrational vector and $T_{\rho }:\mathbb{T}^2\rightarrow \mathbb{T}^2,\, z\mapsto z+\rho $ is a translation, are there natural geometric conditions (e.g., smoothness) on $f$ that force $h$ to be a homeomorphism? In [ 22], the 1st author and Z. Zhang gave a negative answer to the above question in the $C^{\infty }$ category: in general, not even the infinite smoothness condition can force $h$ to be a homeomorphism. In this article, we give a negative answer in the $C^{\omega }$ category (see also [ 22, Question 3]): we construct a real analytic conservative and minimal totally irrational pseudo-rotation of $\mathbb{T}^2$ that is semi-conjugate to a translation but not conjugate to a translation.
A Lethal Aerosol Exposure Model of Nipah Virus Strain Bangladesh in African Green Monkeys
Authors: Prasad Abhishek N , Agans Krystle N , Sivasubramani Satheesh K , Geisbert Joan B , Borisevich Viktoriya , Mire Chad E , Lawrence William S , Fenton Karla A , Geisbert Thomas W 
Published: September 2019

AbstractThe high case-fatality rates and potential for use as a biological weapon make Nipah virus (NiV) a significant public health concern. Previous studies assessing the pathogenic potential of NiV delivered by the aerosol route in African green monkeys (AGMs) used the Malaysia strain (NiVM), which has caused lower instances of respiratory illness and person-to-person transmission during human outbreaks than the Bangladesh strain (NiVB). Accordingly, we developed a small particle aerosol model of NiVB infection in AGMs. Consistent with other mucosal AGM models of NiVB infection, we achieved uniform lethality and disease pathogenesis reflective of that observed in humans.
Arctic Security, Territory, Population: Canadian Sovereignty and the International
Authors: Salter Mark B 
Published: September 2019

AbstractCanada's policies to assert and maintain sovereignty over the High Arctic illuminate both the analytical leverage and blind spots of Foucault's influential Security, Territory, Population (2007) schema for understanding modern governmentality. Governmental logics of security, sovereignty, and biopolitics are contemporaneous and concomitant. The Arctic case demonstrates clearly that the Canadian state messily uses whatever governmental tools are in its grasp to manage the Inuit and claim territorial sovereignty over the High North. But, the case of Canadian High Arctic policies also illustrates the limitations of Foucault's schema. First, the Security, Territory, Population framework has no theorization of the international. In this article I show the simultaneous implementation of Canadian security-, territorial-, and population-oriented policies over the High Arctic. Next, I present the international catalysts that prompt and condition these polices and their specifically settler-colonial tenor. Finally, in line with the Foucauldian imperative to support the “resurrection of subjugated knowledges” (Foucault 2003, 7), I conclude by offering some of the Inuit ways of resisting and reshaping these policies, proving how the Inuit shaped Canadian Arctic sovereignty as much as Canadian Arctic sovereignty policies shaped the Inuit.
Derivation and validation of a machine learning record linkage algorithm between emergency medical services and the emergency department
Authors: Redfield Colby , Tlimat Abdulhakim , Halpern Yoni , Schoenfeld David W , Ullman Edward , Sontag David A , Nathanson Larry A , Horng Steven 
Published: September 2019

AbstractObjectiveLinking emergency medical services (EMS) electronic patient care reports (ePCRs) to emergency department (ED) records can provide clinicians access to vital information that can alter management. It can also create rich databases for research and quality improvement. Unfortunately, previous attempts at ePCR and ED record linkage have had limited success. In this study, we use supervised machine learning to derive and validate an automated record linkage algorithm between EMS ePCRs and ED records.Materials and MethodsAll consecutive ePCRs from a single EMS provider between June 2013 and June 2015 were included. A primary reviewer matched ePCRs to a list of ED patients to create a gold standard. Age, gender, last name, first name, social security number, and date of birth were extracted. Data were randomly split into 80% training and 20% test datasets. We derived missing indicators, identical indicators, edit distances, and percent differences. A multivariate logistic regression model was trained using 5-fold cross-validation, using label k-fold, L2 regularization, and class reweighting.ResultsA total of 14 032 ePCRs were included in the study. Interrater reliability between the primary and secondary reviewer had a kappa of 0.9. The algorithm had a sensitivity of 99.4%, a positive predictive value of 99.9%, and an area under the receiver-operating characteristic curve of 0.99 in both the training and test datasets. Date-of-birth match had the highest odds ratio of 16.9, followed by last name match (10.6). Social security number match had an odds ratio of 3.8.ConclusionsWe were able to successfully derive and validate a record linkage algorithm from a single EMS ePCR provider to our hospital EMR.
Gene expression profiling of the bone trabecula in patients with osteonecrosis of the femoral head by RNA sequencing
Authors: Bai Haobo , Chen Tingmei , Lu Qian , Zhu Weiwen , Zhang Jian 
Published: September 2019

Abstract
Early diagnosis and treatment of osteonecrosis of the femoral head (ONFH) is challenging. Bone trabecula play a vital role in the severity and progression of ONFH. In the present study, the investigators used gene expression profiling of bone trabecula to investigate gene alterations in ONFH patients. Osteonecrotic bone trabecula (ONBT) such as necrosis, fibrosis, and lacuna were confirmed by histological examination in the patients. The adjacent ‘normal’ bone trabecula (ANBT) did not show any pathological changes. Gene sequencing data revealed that although ANBT showed no significant histological changes, alteration of mRNA profiling in ANBT was observed, similar to that in ONBT. Our results indicated that the alteration of mRNA profiling in ANBT may cause normal bone tissue to develop into necrotic bone. RNA-seq data indicated that 2,297 differentially abundant mRNAs were found in the ONBT group (1,032 upregulated and 1,265 downregulated) and 1,523 differentially abundant mRNAs in the ANBT group (744 upregulated and 799 downregulated) compared with the healthy control group. Gene ontology (GO) enrichment analysis suggested that fatty acid metabolism and degradation were the main zones enriched with differentially expressed genes (DEG). Kyoto encyclopedia of genes and genomes (KEGG) pathway enrichment analysis indicated that peroxisome proliferator-activated receptor γ (PPAR-γ) pathway was the most significantly regulated pathway. Lipocalin-2 (LCN2), an osteoblast-enriched secreted protein, was significantly decreased in ONBT suggesting that downregulation of LCN2 might affect lipid metabolism and lead to hyperlipidemia, and thus promote pathogenesis of ONFH.
The End of Enlightened Environmental Law?
Authors: Preston Brian J 
Published: September 2019

Abstract
The rise of populism threatens enlightened environmental law. In an age where ignorance is seen as a virtue, not a vice, environmental laws risk regression. No longer are debates about environmental problems driven by opinions founded on evidence, scientific method and reason. Instead, these debates, and how the law should address them, are driven by differing ways of viewing the world. Populists play on cultural biases and intuitive reasoning, personalise politics and use seductive slogans to distort the reality of environmental problems. As we become further estranged from our natural environment, people no longer can verify or deny these populist claims. This comment examines some of the ways populism has taken hold of environmental governance and how it might be addressed.
Quality factor estimation based on the peak frequency shift method using a robust Fourier transform to VSP data
Authors: Sandoval Rómulo , Paredes José L , Vivas Flor A 
Published: September 2019

AbstractQuality factor estimation (Q estimation) of vertical seismic profile (VSP) data are necessary for the process referred to as inverse Q-filtering, which is used, in turn, to improve the resolution of seismic signals. In general, the performances of Q estimation methods, based on the standard Fourier transform, are severely degraded in the presence of heavy-tailed distributed noise. In particular, these methods require a bandwidth detection which is difficult to estimate due to instabilities caused by outliers or gross errors, leading to an incorrect Q estimation. In this paper, an improvement of the Q-factor estimation based on the peak frequency shift method is proposed, where the signal spectrum is obtained using a robust transform algorithm. More precisely, the robust transform method assumes that the perturbations that contaminate the signal of interest can be characterized as random samples following a zero-mean Laplacian distribution, leading to the weighted median as the optimal operator for determining each transform coefficient. The proposed method is validated on synthetic datasets using different levels of noise and its performance is compared to those yielded by various methods based on the standard Fourier transform. Furthermore, a non-Gaussianity test is performed in order to characterize the noise distribution in real data. From the non-Gaussianity test, it can be observed that the underlying noise is better characterized using a Laplacian statistical model, and therefore, the proposed method is a suitable approach for computing the Q factor. Finally, the proposed methodology is applied to estimate the Q factors of real VSP data.
Theorizing the Temporal Exception: The Importance of the Present for the Study of War
Authors: McIntosh Christopher 
Published: September 2019

AbstractDespite an increasing focus on the importance of temporality, time, and timing in international relations (IR) and security studies, there has been relatively less movement toward thinking about the temporal present as a conceptual area of inquiry. This article argues that taking the present seriously as a concept, method, and theoretical area of analysis offers unique value for the study of war. Paying attention to the manner in which the present time of war (wartime) is sociopolitically articulated as a space of temporal exception exposes how it is understood as diverging from representations of politics, past and future. It also foregrounds war's irreducible temporal dimension and exposes the relational bases of wartime's apparent universality. This article uses a close reading of Clausewitz's On War (1832) as generative dialogue and illustrative example, showing how an awareness of the importance of temporal dynamics—particularly, the concept of the present—is both valuable and workable in the study of war. A temporal imaginary of war centered on what Hutchings calls the “heterotemporal” present enhances inquiry into contemporary political violence, the ontology of war, and the emergent attributes of collective violence.