bluuebunny/crossref_metadata_2025_split huggingface dataset:
Coronary calcinosis and psychological distress association, by the data from ESSE-RF study in Kemerovskaya Region
Authors: Sumin A. N. , Raikh О. I. , Kokov A. N. , Indukaeva E. V. , Artamonova G. V. 
Published: November 2018

Aim. To evaluate the association of coronary arteries calcinosis with personality type D, by ESSE-RF (Epidemiology of cardiovascular diseases and risk factors in various regions of Russian Federation) trial data in Kemerovskaya Oblast.Material and methods. The study has been done under the framework of ESSE-RF trial. Standard protocol was updated with personality type assessment by DS-14 questionnaire. All patients underwent quantitative assessment of coronary calcinosis with multispiral computed tomography. The data package was analyzed with Agatstone method. Two groups of patients collected: group 1 (n=231) with type D personality, and group 2 with non-D (n=1379).Results. With the evaluation of calcium index (CaI) there were significant differences in groups: 689,3+53,7 in type D patients and 546,5+47 with none (p=0,048). Moderate and severe CaI was higher in type D patients — 10,3% and 12,5% vs 5,8% and 2,9%, respectively (p=0,043 and p=0,011). Highest differences in CaI in the left coronary artery, exactly in the left anterior descending, were 189,1+12,5 in type D vs 155,6+16,7 in non-type D (p=0,011), and circumflex artery — 121,7+30,6 vs 63,8+21,7 (p=0,032). With the logistic regression, the most influencing on moderate and severe CaI were age — hazard ratio (HR) 1,07-2,14 (p=0,023), diabetes — HR 1,32; 95% CI 1,09-1,62 (p=0,032), type D personality — HR 1,42; 95% CI 1,12-1,82 (p=0,023), coronary heart disease — HR 1,12; 95% CI 1,01-1,21 (p=0,034). By the multifactorial analysis, as independent predictors of moderate and severe CI remained such parameters as coronary heart disease — HR 1,24 95% CI 1,01-1,53 (р=0,04), diabetes — HR 1,28; 95% CI 1,80-3,24 (р=0,02) and type D — HR 1,49; 95% CI 2,01-2,29 (р=0,01).Conclusion. Screening for the influence of type D personality is worthy in persons with subclinical coronary arteries lesion to conduct on-time preventive events.
The relationship and interinfluence of aspects of therapy safety and compliance in patients with cardiovascular diseases (by the data from outpatient registry “PROFILE”)
Authors: Lukina Yu. V. , Dmitrieva N. A. , Kutishenko N. P. , Kiseleva N. V. , Martsevich S. Yu. 
Published: November 2018

Aim.To study the relationship and interinfluence of aspects of therapy safety and compliance in patients with chronic cardiovascular diseases (CVD) and their risk factors in the framework of outpatient prospective register “PROFIL”.Material and methods.The register method, enriched by two original questionnaires evaluating some safety pharmacotherapy guides and compliance, was used. We also practiced 8-item Morisky Medication Adherence Scale (MMAS-8) to assess overall compliance. The survey was undertook from September 1, 2017 to May 31, 2018. All together 167 of 177 people completed the questionnaires, 162 questionnaires of 80 women and 82 men were analyzed. The mean age of patients was 67,2±11,1 years. One hundred thirty participants answered all the questions of MMAS-8.Results.We determined that 46 (28,4%) of 162 patients had various adverse events (AE) of pharmacotherapy in history, half of patients (54,3) denied the presence of AE, other participants find difficult to answer this question. According to the data of original questionnaire, almost all patients (n=158, 97,5%) were given medical recommendations for taking medications. Also 145 (91,7%) of 158 patients noted that they were taking the prescribed drugs, but only 117 patients follow blindly recommendations, 13 people did not take drugs. According to the results of MMAS-8, 77 (59,2%) people did not follow recommendations, and 53 patients fully followed them. Regular visits to the attending physician and informing the patient by the doctor, including about AE, significantly increased overall compliance (p<0,05). No significant relationship was found between the number of drugs taken and AE. Patients who had no previous AE, rarely did not follow recommendations (13%), among patients with registered AE there were more cases of low compliance (27,5%, (p=0,044)). In patients who changed the dosage of medication on their own or cancel it, AE were observed more frequently (p<0,0001). The absence of AE in a patient fivefold increases the chances that he will follow recommendations — odds ratio: 5,2, 95% confidence interval: 1,2; 22,9 (p=0,028).Conclusion. Robust relationship and interinfluence of aspects of therapy safety and compliance, confirmed by the results of the study, determine advanced directions: optimizing the doctor-patient relationship, increasing patient awareness, rational drug use and etc. The lack of ways for obtaining of reliable and complete information about safety indicators and comliance in clinical practice is an important factor preventing the solution of the problem.
Antihypertension drugs in prevention of cognition disorder and dementia: focus on calcium channel blockers and diuretics
Authors: Ostroumova O. D. , Chernyaeva M. S. 
Published: November 2018

Arterial hypertension is associated with elevated risk of cognition decline and vascular dementia development, as the Alzheimer disease development. Therefore, antihypertension therapy might be of preventive value. The review is focused on literary data that witness on, despite controversial, evidence of cerebroprotective action of the range of antihypertension medications. Especially, dihydropyridine calcium antagonists, diuretics and some blockers of renin-angiotensin-aldosterone system. These act not only via blood pressure decrease, but due to additional specific neuroprotective mechanisms. This makes it to consider calcium antagonists and diuretics as a major component of systemic hypertension management, incl. elderly and senile patients, aiming to prevent cognition decline and dementia of various types development.Nitrendipine, among the calcium channels antagonists, and indapamide among diuretics have acquired the broadest evidence that points on their cerebroprotective properties.
Normal Stress Analysis In an Infinite Elastic Body With A Locally Curved Carbon Nanotube
Authors: ŞİMŞEK ALAN Kadriye 
Published: November 2018

Bu çalışmada, yerel eğrilikli
karbon nanotüp içeren tek yönlü lifli kompozit malzemelerde normal gerime
dağılımına ait sonuçlar ikinci yaklaşıma kadar elde edildi ve elde edilen
sonuçlar analiz edildi. Problem çözümü için sınır formu pertürbasyon yöntemi
kullanıldı. Araştırmalar parçalı homojen cisim modeli çerçevesinde elastisite
teorisinin üç boyutlu geometrik nonlineer kesin denklemleri kullanılarak
yapıldı. Kompozitteki karbon nanotüplerin yoğunluğu düşük kabul edildi ve
karbon nanotüpler arasındaki etkileşim ihmal edildi. Normal gerilme dağılımı
ile ilgili çok sayıda sonuç bulundu ve parametrelerinin bu gerilme dağılımına
etkisi analiz edildi.
La prosodia en el derecho romano antiguo: la prosa rítmica de la ley de las doce tablas
Authors: Campos Vargas Henry Ernesto 
Published: November 2018

Este artículo estudia algunas características particulares en la prosodia de la <em>Lex Duodecim Tabularum.</em> En la exposición, se considera si algunos versos saturnios o quadrati están presentes en esta importante ley. Finalmente, se muestra cómo las cláusulas rítmicas influyeron en este código.
CONCEPT OF MARDANA: A REVIEW
Authors: Hussain Gazala 
Published: November 2018

Rasashastra is a branch of Ayurveda pharmaceutics that deals with preparation of formulations using mineral, metals, marine drugs, gemstones, etc. It is a branch that has mercury as its center. Many processing types have been mentioned in Indian alchemy, most of the processes mentioned are for making Parada develops lohavada and dehavada property. There are also procedures and samskaras mentioned to potentiate the formulations or drugs. One such samskara (process) is mardana samskara that is used as a purification procedure of Parada as well as a bhavana for preparing Khalviya yogas (preparation made in mortar and pestle).
Keywords: Rasashastra, Mardana, shodhana, processes
DIFFERENTIAL EFFECT OF PURIFIED QUERCETIN AND ITS DERIVATIVES FROM IN VITRO CELL SUSPENSION CULTURES OF CAESALPINIA PULCHERRIMA SW. AGAINST SELECTED CANCER CELL LINES AND ITS MODE OF ACTION
Authors: Aswathy JM , Murukan Greeshma , Lawarence Bosco , Murugan K 
Published: November 2018

Tribal people use the floral extract of Caesalpinia pulcherrima to cure liver, stomach and skin prone disorders in traditional Indian medicine. This study aimed to evaluate the effect of purified quercetin and its derivatives from in vitro cell suspension cultures of C. pulcherrima Sw. against SW 480, HeLa, MCF-7 and MCF 10A cell lines and its mode of action. Standard protocol was developed for callus induction using leaf explants. Cytotoxic effect was evaluated against SW 480, HeLa, MCF-7 and MCF 10A cells by MTT assay. Apoptosis was evaluated via Hoechst analysis, flow cytometry, mitochondrial membrane potential and caspase 3 and 9 expression. 2, 4-D (2.5 mg/l), BAP (2.5 mg/l) + kin (1 mg/ml) was effective for remarkable callus induction. Further, cell suspension culture was established. Effect of elicitors on cell suspension culture was also carried. Sucrose, ABA and salicylic acid (SA) at different concentrations influenced cell biomass and quercetin synthesis. Cells cultured on the medium fortified with 45 g/L sucrose without ABA/SA showed the highest quercetin content (16.5 mg/g). Quercetin was purified, fractionated by HPLC-DAD and was further analyzed by NMR revealed a major fraction of quercetin (3, 5, 7, 3’, 4’-pentahydroxyflavon). Insignificant cytotoxicity was noticed in SW 480, HeLa, MCF 10A when compared to MCF-7 cell lines exposed to different concentrations of purified quercetin for 24- 48 h. Similarly, the apoptosis by nuclei staining using Hoechst 33258 revealed a concentration dependent effect on MCF 7 cells only. This was further substantiated by caspase-9 and 3 induction and mitochondrial depolarization as revealed by flow cytometry. Overall, the results showed that quercetin and its derivatives induced effective apoptosis on MCF-7 cells. Quercetin isolated from the in vitro cell suspension culture of C. pulcherrima showed significant cytotoxicity and apoptotic activity towards MCF-7 cell lines as compared to other cell lines.
Keywords: Caesalpinia pulcherrima; quercetins; suspension culture; cytotoxicity; apoptotic.
A COMPARATIVE STUDY ON MONOTHERAPY AND COMBINATION THERAPY OF PANTOPRAZOLE WITH PREGABALIN AGAINST SURGICAL ESOPHAGITIS
Authors: Afrin Rafat , Sangeet Sangeet , Tripathy Surendra 
Published: November 2018

The objective of this study was to evaluate the effect of pantoprazole and pregabalin on experimental esophagitis in albino rats. The groups of rats fasted for 24 hours and were subjected to pylorus and forestomach ligation. Rats of different groups received normal saline (3 ml/kg, po; sham control), pantoprazole (30 mg/kg, po), pregabalin (30 mg/kg, po) and their combinations along with a parallel toxic control group. Animals were sacrificed after 8 h and evaluated for the gastric pH, total acidity, free acidity and esophagitis index. The morphological changes were scrutinized by digital microscopy. The beneficial effect of pantoprazole and pregabalin against GERD could be attributed to the anti-secretory action of pantoprazole and reduction in the tracheal lower esophageal sphincter release rate by pregabalin. Combination therapy of gamma-aminobutyric acid derivative promotes proton pump inhibitor based healing of reflux esophagitis in animal model.
Keywords: Esophagitis, Pantoprazole, Pregabalin, Pylorus ligation, Gamma-aminobutyric acid.
STRESS MANAGEMENT TECHNIQUE FOR ATHLETES DURING SPORTS: A CRITICAL REVIEW
Authors: Bhadauriya Brajendra , Tripathi Rajesh 
Published: November 2018

Stressors have a major influence upon mood, our sense of well-being, behavior, and health. Acute stress responses in young, healthy individuals may be adaptive and typically do not impose a health burden. However, if the threat is unremitting, particularly in older or unhealthy individuals, the long-term effects of stressors can damage health. This paper attempts to look at the strategies for sports coaches in managing stressful situations in sports competitions. This paper therefore, writes in the introduction, the concepts of stress, competition based stress, management, stress management in sports, stress in sports psychology. The paper also examines the sources of stress. It looks critically at the levels of stress in competitive sports. The relationship between psychosocial stressors and disease is affected by the nature, number, and persistence of the stressors as well as by the individual’s biological vulnerability (i.e., genetics, constitutional factors), psychosocial resources, and learned patterns of coping. Psychosocial interventions have proven useful for treating stress-related disorders and may influence the course of chronic diseases. The paper also highlights some specific stress management strategies which sports coaches have to employ to aid excellent performance in sports competition. It also identifies the educational implications of stress management in sports competitions.
Keywords: Psychosocial stressors, Stress responses, Sports, psychosocial interventions, Stressor interactions, Stress management.
USE OF THE PHARMACEUTICAL CARE PROGRAM IN THE MANAGEMENT OF PATIENTS WITH TYPE 2 DIABETES MELLITUS IN DHULE CIVIL HOSPITAL
Authors: Mujawar Tabrej , Patil Prakash Hiraman 
Published: November 2018

Aim & Objective: The study was planned to evaluate the effectiveness of pharmaceutical care on the control of medical parameters, such as Fasting plasma glucose, Glycosylated hemoglobin (HbA1c) and BMI also to evaluate drug therapy problems in patients with type 2 diabetes mellitus. Setting: the study was conducted at SBHGM College, Civil Hospital in Dhule MS.
Research design and Methods: A prospective, Open label and randomized control study was conducted with 200 type 2 diabetes patients with glycosylated haemoglobin of higher than 7.5%, they were divided into two groups: (I) control group without pharmaceutical care program (n=100), and (II) pharmaceutical care program (intervention) group (n=100).They were monitored for 3 consecutive visits. Patients in the control group received usual medical care, but patients in the intervention group received both standard medical care and pharmaceutical care.
Results: At the end of the study, a statistically significant fall was observed in the glycemic levels, BMI of patients in the intervention group as a small reduction, which is statistically not significant, was observed in the control group. Additionally, the follow-up of the intervention group by a pharmacist contributed to the resolution of 118 drug therapy problems identified.
Conclusion: pharmaceutical care program provide by pharmacist to patients with type 2 diabetes mellitus can give up measurable improvements in the glycemic control, BMI & resolute of drug therapy problems and improvements in the adherence to antidiabetic medication.
Keywords: Type 2 Diabetes mellitus, Pharmaceutical care program, and Fasting plasma glucose, Glycosylated hemoglobin (HbA1c) and Body mass index (BMI).
LONG-TERM INCIDENCE OF CERVICAL CANCER IN WOMEN WITH HUMAN IMMUNODEFICIENCY VIRUS
Authors: Golden Subhash Kumar Mishra , Vishnoi Nidhi 
Published: November 2018

Background: The objective of this study was to estimate the incidence of invasive cervical cancer (ICC) in women with human immunodeficiency virus (HIV) and compare it with the incidence in HIV-uninfected women.
Methods: In a cohort study of HIV-infected and uninfected women who had Papanicolaou tests obtained every 6 months, pathology reports were retrieved for women who had biopsy results or a self report of ICC. Histology was reviewed when reports confirmed ICC. Incidence rates were calculated and compared with those in HIV-negative women.
Results: After a median follow-up of 10.3 years, 3 ICCs were confirmed in HIV-seropositive women, and none were confirmed in HIV-seronegative women. The ICC incidence rate was not found to be associated significantly with HIV status (HIV-negative women [0 of 100,000 person-years] vs HIV-positive women [21.4 of 100,000 person-years]; P = .59). A calculated incidence rate ratio standardized to expected results from the Surveillance Epidemiology and End Results database that was restricted to HIV-infected Women’s Interagency HIV Study participants was 1.32 (95% confidence interval, 0.27-3.85; P = 0.80).
Conclusions: Among women with HIV in a prospective study that incorporated cervical cancer prevention measures, the incidence of ICC was not significantly higher than that in a comparison group of HIV-negative women.
Keywords: Cervical Cancer, Human Immunodeficiency Virus, Women, Cancer Prevention.
DESIGN AND IN VITRO EVALUATION OF EXTENDED RELEASE TABLET OF NATEGLINIDE
Authors: MAHAJAN NILESH M , Wanaskar Kalyanee , Bhutada Yogesh , Thenge Raju , Adhao Vaibhav 
Published: November 2018

The aim of present study is to formulate and evaluate extended release matrix tablet of Nateglinide by direct compression method using different polymer like HPMC K4 and HPMC K15. Matrix tablet of nateglidine were prepared in combination with the polymer HPMC K4, HPMC K15, along with the excipients and the formulations were evaluated for tablet properties and in vitro drug release studies. Nateglinide matrix tablet prepared by using polymer such as HPMC K4 and HPMC K15, it was found that HPMC K15 having higher viscosity as compare to HPMC K4 therefore different concentration of polymer were studied to extend the drug release up to 12 h. The tablets of Nateglinide prepared by direct compression had acceptable physical characteristics and satisfactory drug release. The study demonstrated that as far as the formulations were concerned, the selected polymers proved to have an acceptable flexibility in terms of in-vitro release profile. In present the study the percent drug release for optimize batch was found to 94.62%. Hence it can be conclude that Nateglinide extended release matrix tablet can prepared by using HPMC. The swollen tablet also maintains its physical integrity during the drug release study
Keywords: Tablet, in-vitro drug release, Nateglinide, HPMC
Membangun Struktur Realtime Database Firebase Untuk Aplikasi Monitoring Pergerakan Group Wisatawan
Authors: Sudiartha I Ketut Gede , Indrayana I Nyoman Eddy , Suasnawa I Wayan 
Published: November 2018

Penelitian ini fokus pada merancang dan membuat struktur realtime database firebase untuk aplikasi monitoring pergerakan wisatawan. Firebase merupakan salah satu cloud database yang memang didesain untuk cloud application. Database Firebase mengutamakan waktu akses data. Aplikasi ini berbasis android yang melibatkan banyak user didalamnya. Sehingga membutuhkan struktur database yang kokoh untuk menopang aplikasi ini supaya dapat berjalan secara optimal. Data yang disimpan di sisi server adalah data latitude dan longitude dari posisi wisatawan. Data posisi latitude dan longitude ini diperoleh dari Satelite GPS melalui permintaan posisi dari masing – masing smartphone wisatawan. Aktor utama dalam aplikasi ini adalah tour leader(guide) dan anggota group wisatawan (guest). Database yang dibangun melibatkan 2 node besar yaitu node “Guide” dan node “ChatGroup” dimana sebelumnya telah melalui proses perataan struktur database. Proses pembuatan struktur model data firebase, juga perlu memperhatikan bagaimana data tersebut disajikan dalam antar muka user sehingga waktu akses data menjadi lebih optimal.
Determining the Some Heavy Metal Content of Pinus sylvestris Needles and Soil in the Urban Forest by the Side of the Road
Authors: ÇOMAKLI Emre , BİNGÖL Mehmet Semih , ÇOMAKLI Tuğba 
Published: November 2018

One of the significant factors having a role in
plant development is elements. Decrease in quantities of some elements results
in plant nutrition disorders while increase of them might do harm to plant.
Apart from that, there are elements that affect plants in terms of toxic effect.
They are mostly heavy metals. Heavy metals with industrial-based and
transportation-based pollutants have an impact on natural environment. It is
clear that plants are affected by environmental factors, too. Heavy metal
pollution in soil is also one of the significant environmental problems. It has
a big influence on human and animal health via food chain. Hence, it is quite
vital to recognize the type and the amount of heavy metal as well as reasons
causing accumulation in the sense of plant development and soil health.

In this sense, the aim of the present research
is to determine the effects based on heavy metals especially vehicle-driven on
plants and soil by using scotch pine needles and soil samples. In the study, it
is confirmed that heavy metal accumulation is too much by the side of the road
where there is a traffic density while the accumulation rate is getting lower
and lower as you step into woods.
IMPROVEMENT OF AWARENESS AND ASPECT OF COMMUNITY PARTICIPATION IN ENVIRONMENTAL MANAGEMENT AND CLIMATE CHANGE ADAPTATION BY ECO-MOSQUE
Authors: Auvaria Shinfi Wazna 
Published: November 2018

Climate change and environmental pollution are some of the current environmental issues of global concern. One in six people died in 2015 due to environmental pollution. Climate change that occurs can be seen from the recent number of rainy season shift and extreme natural disasters. IPCC’s fifth Assessment report says that there are 95% chance of human activity in the last 50 years is the trigger of climate change. Some means to achieve SDG’s targets and solving environmental problems are increasing awareness and aspects of community participation in the settlement, including adaptation and mitigation of climate change. Some countries with a majority of the population of Muslims, there is Authentic Islamic Environmental Movement. One of the adapted program is EcoMosque as one of the ways to increase awareness and to increase aspects of community participation in overcoming environmental problems in Indonesia. EcoMosque is very possible to be done in Indonesia because supported by the majority of Islamic’s population which is very potential in the implementation
ANALISIS DAMPAK ENSO (EL-NINO SOUTHERN OSCILLATION) TERHADAP TINGKAT KEKERINGAN UNTUK TANAMAN PANGAN DAN PALAWIJA (STUDI KASUS : SULAWESI SELATAN)
Authors: Sugiarto Yon , Kurniawan Dori 
Published: November 2018

<p>Weather and climate variability is a long-term weather changes that are characterized by fluctuations and deviations from normal conditions. One possible cause is the ENSO (El-Nino Southern Oscillation) which affected in drought events. This research was conducted to determine and analyze the level of drought in South Sulawesi due to the influence of ENSO and compare the production of food crops and secondary food crops in normal years and ENSO.<br />Drought index is calculated based on the Palmer method by using data of rainfall, air temperature and soil moisture as input. Based on the calculations using the method of Palmer drought index, the regions with monsoon rain patterns have a range of values between -22.71 drought until 18:23, Equatorial patterns ranging from -4.03 to 5:07, and on local patterns ranged<br />from -8.57 until 10:07. Verification test results on the drought index of crop production data showed that each ENSO event is always followed by a decline in rice production, especially of rice fields. Food crop production generally tends to increase at each ENSO event because most crops are plants that are resistant to drought, particularly local varieties that have adapted well to their environment. Thus, the drought caused by the influence of ENSO can affect the production of food crops and secondary food crops.</p>