bluuebunny/crossref_metadata_2025_split huggingface dataset:
Unlocking Potential: Analyzing the Content, Style, Structure, and Interactivity of Mesonets as Operational Dashboards
Authors: Olivas Savannah , Sutton Jeannette , Olson Micki 
Published: November 2024

Abstract
Emergency managers need data and information to make life-saving decisions on behalf of the public. Operational dashboards, if designed appropriately, can provide this information in a central location and reduce cognitive demands during decision-making. Mesonet websites can serve as a type of operational dashboard that has the potential to provide the meteorological data necessary for emergency managers to make decisions. In this study, we use quantitative content analysis to examine the content, style, structure, and interactivity of 18 Mesonet websites from across the contiguous United States. We find that Mesonet websites vary in the type and amount of content they include. For website style, we find that Mesonet websites primarily present their content with maps and data filters. We find that the structure of the website content was consistent across websites. Finally, we find that most Mesonet websites lacked interactivity, or visual feedback, which inhibits ease of use. We discuss extensions for future work.

Significance Statement
This study captures the content, style, structure, and interactivity of Mesonet websites when they are used as operational dashboards to support weather-related decision-making. Weather dashboards have the potential to support decision-makers of all types during severe weather events by providing all critical information in one place. With this streamlined approach, decision-making is made more efficient, as gathering information from multiple sources is no longer necessary. Mesonet dashboards provide a valuable context to analyze the content, style, and structure of webpages that can be useful for users. Through this work, we hope to identify the design principles and trends present in these dashboards, providing a basis for future research and efforts to improve design, user experience, and accessibility.
Uncommon Yet Critical: A Case Report of Bilateral Haemorrhagic Thalamic Infarction in a Febrile Infant
Authors: Ebinesh A  , Ashta Aanchal , Krishna Ganesh , Pradhan Gaurav Shanker , Saxena Swarna , Saifi Alfa Shamim 
Published: November 2024

Background: Cerebral venous thrombosis (CVT) is a rare form of stroke in infants and young children, with multifactorial causation and a poor prognosis. Bilateral haemorrhagic thalamic infarction secondary to deep CVT is an extremely rare presentation. Case report: We report the case of a 12-month-old infant with bilateral haemorrhagic thalamic infarction secondary to deep CVT, presenting with fever and seizures. The infant was initially diagnosed with acute meningoencephalitis of viral aetiology and treated accordingly. However, the patient had a sudden clinical deterioration. Neuroimaging revealed deep CVT with bilateral haemorrhagic thalamic infarction. Anticoagulant therapy in conjunction with physiotherapy was initiated and the infant gradually improved and was discharged. Conclusion: CVT is a rare form of stroke in infants and young children, with multifactorial causation and poor prognosis. Our case highlights the importance of careful evaluation of cerebral venous drainage on routine neuroimaging in infants with fever and seizures, especially in those who do not respond to standard treatment for meningoencephalitis. Synopsis: Here we report a unique and challenging case of deep cerebral venous thrombosis with haemorrhagic infarction of bilateral thalami mimicking viral encephalitis in an infant with acute febrile encephalopathy.
Analyse des conditions à l’utilisation de l’évaluation réaliste par des équipes de promotion de la santé : résultats d’une étude de cas multiples en région bruxelloise (Belgique)
Authors: Malengreaux Ségolène , Doumont Dominique , Lambert Anne-Sophie , Aujoulat Isabelle 
Published: November 2024

Introduction : L’évaluation réaliste est de plus en plus plébiscitée dans le champ de la promotion de la santé. Pourtant, cette démarche d’évaluation est encore très peu utilisée par, ou même avec, des équipes de terrain, ce qui vient limiter sa portée pour les pratiques de terrain. Notre étude propose d’explorer les conditions favorables à la pratique de l’évaluation réaliste par des équipes de promotion de la santé. Méthodes : Cette étude s’inscrit dans le cadre d’une étude de cas multiples impliquant une chercheuse et quatre équipes de promotion de la santé en Région de Bruxelles-Capitale. Des données qualitatives ont été collectées tout au long de l’expérimentation de l’évaluation réaliste de projets de promotion de la santé avec les quatre équipes bruxelloises. Résultats : Nos résultats montrent l’intérêt de l’évaluation réaliste pour orienter les pratiques évaluatives des acteurs de terrain vers des pratiques favorables à la réflexivité. Ils montrent aussi les difficultés rencontrées et les ressources sur lesquelles s’appuyer pour les surmonter. Quatre conditions sont ainsi mises en évidence pour mener une évaluation réaliste de manière participative et capacitante. Conclusion : Notre étude encourage à envisager de nouveaux repères pour une pratique pragmatique de l’évaluation réaliste dans le champ de la promotion de la santé, axée sur la participation et la capacitation des parties prenantes.
Impact of Brief Lactation Rotation in Residency on Decision to Refer for Lactation Support
Authors: Kindred Megan M. , Barta Kelsie R. 
Published: November 2024

Introduction: Breastfeeding challenges may be difficult to address within the constraints of a typical well-child visit. A team-based approach, including lactation consultants, can reduce physician workload, increase breastfeeding self-efficacy, and increase patient satisfaction. Continuity of care issues, including absent or delayed referrals, hinder patient access to skilled lactation support. Objectives: To examine the post-residency referral patterns of physicians to lactation consultants among physicians who did or did not participate in a brief outpatient lactation rotation at an academic lactation clinic during residency. Methods: A cross-sectional online survey of physicians who completed residency programs in pediatrics, family medicine, or medicine-pediatrics between 2013 and 2022 was conducted using REDCap; 46 valid responses were received. Results: Respondents who participated in a brief outpatient lactation rotation during residency refer patients to lactation consultants with significantly higher frequency than those who did not complete the rotation. Among those with lactation consultants in their geographic area, this relationship remained significant even when adjusting for residency type, gender, experience with an inpatient lactation consultant, and infant feeding attitudes using multiple linear regression. Conclusions: An outpatient lactation rotation during medical residency may increase the likelihood of referring to a lactation consultant in post-residency practice, which can improve breastfeeding outcomes.
Qigong and Tai Chi for ME/CFS: A Systematic Review of Randomized Controlled Trials
Authors: Markwart Michaela , Felsenstein Donna , Mehta Darshan H. , Sethi Samreen , Tsuchiyose Erika , Lydson Melis , Yeh Gloria Y. , Hall Daniel L. 
Published: November 2024

Objective Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a chronic and debilitating illness with symptoms such as post-exertional malaise and cognitive dysfunction that can be challenging for patients to manage independently. Randomized controlled trials (RCTs) have examined mind-body and psychological approaches that teach patients coping skills for mitigating ME/CFS symptoms, including emerging literature on Qigong or Tai Chi instruction programs. This systematic review aims to summarize the characteristics of these trials and highlight potential areas for future optimization and refinement. Methods Ovid MEDLINE, Embase.com, Web of Science Core Collection, Cochrane CENTRAL, PsycINFO via Ovid, and ClinicalTrials.gov were searched in April 2023 using controlled vocabulary and keywords for the following eligibility criteria: Sample (ME/CFS), Design (RCT), Behavioral Intervention (mind-body or psychological interventions). Data extraction and reporting followed Cochrane and Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Results “Qigong” and “Tai Chi” yielded 142 and 80 abstracts, respectively. Of the 222 abstracts, full texts were available for 5 RCTs of Qigong ( k = 5; N = 481). Notably, no trials of Tai Chi utilized a randomized control design. Among the 5 Qigong RCTs, the publication range was from 2012 to 2023. Details regarding intervention components and effects were summarized. Qigong intervention sessions (median = 12, mode = 10, 12) tended to last between 1-2 hours and occur across 5-12 weeks (median = 7, mode = 5). The Qigong interventions were all delivered in groups and incorporated at-home practice. Daily practice was a requirement ( k = 4) or an advisement ( k = 1). Patient-reported outcomes suggest an emerging evidence base for diffuse benefits on physical and emotional health outcomes. Conclusions Qigong interventions are promising, yet relatively understudied, in improving ME/CFS symptom severity and frequency. Future trials must implement standardized eligibility criteria for ME/CFS history, integrate Qigong or Tai Chi with other empirically supported mind-body and psychological practices, and assess long-term resiliency outcomes relevant to ME/CFS survivorship.
Respiratory support and bronchopulmonary dysplasia in infants born at 22–26 weeks gestation in Sweden, 2004–2007 and 2014–2016
Authors: Löfberg Linn , Abrahamsson Thomas , Björklund Lars J. , Hellström Westas Lena , Farooqi Aijaz , Domellöf Magnus , Ådén Ulrika , Gadsbøll Christian , Källén Karin , Ley David , Normann Erik , Sävman Karin , Elfvin Anders , Håkansson Stellan , Norman Mikael , Sindelar Richard , Serenius Fredrik , Um-Bergström Petra 
Published: November 2024

BackgroundOur aim was to evaluate if increased survival and new ventilation strategies were accompanied by a changed incidence of bronchopulmonary dysplasia (BPD) in Sweden over a decade.MethodsData from two Swedish population-based studies of live-born infants with gestational age (GA) 22–26 weeks, born during 2004–2007 (n=702) and 2014–2016 (n=885), were compared for survival, any BPD, moderate BPD and severe BPD and the composite outcomes of any BPD or death and severe BPD or death at 36 weeks postmenstrual age (PMA). Ventilation strategies and interventions were analysed. Any BPD was defined as the use of supplemental oxygen or any respiratory support at 36 weeks PMA, moderate BPD as nasal cannula with <30% oxygen and severe BPD as ≥30% oxygen, continuous positive airway pressure (CPAP) or mechanical ventilation.ResultsSurvival to 36 weeks PMA increased from 72% to 81% (p<0.001). Total days on mechanical ventilation increased from a median of 9 to 16 days (p<0.001). High-flow nasal cannula (HFNC) was introduced between the cohorts, and days of CPAP and HFNC increased from 44 to 50 days (p<0.001). Any BPD was unchanged at 65%versus68%. Moderate BPD increased from 37% to 47% (p=0.003), while the incidence of severe BPD decreased from 28% to 23% (p<0.046). Severe BPD or death decreased from 48% to 37% (p<0.001), while any BPD or death remained unchanged at 74%versus75%.ConclusionEven though an increased survival of infants born at 22–26 weeks GA was accompanied by an increased duration of invasive and non-invasive respiratory support, the incidence of any BPD remained unchanged, while severe BPD decreased in infants alive at 36 weeks PMA.
Relationship between age, sex, geography and incidence of nontuberculous mycobacteria in Denmark from 1991–2022
Authors: Dahl Victor N. , Pedersen Andreas A. , van Ingen Jakko , Andersen Aase B. , Lillebaek Troels , Wejse Christian M. 
Published: November 2024

ObjectivesTo investigate age, sex, and geographical differences in nontuberculous mycobacteria (NTM) incidence in Denmark.MethodsA nationwide register-based study of all patients with NTM isolates in Denmark from 1991 through 2022 based on centralised microbiological data from The International Reference Laboratory of Mycobacteriology, Statens Serum Institut, Copenhagen, Denmark. A Poisson regression model was used to calculate incidence rates (IRs) and rate ratios (IRRs).Results4123 patients had NTM isolated for the first time. Their median age was 59 years (Interquartile range 33–72), which increased over time. Males were younger than females. The proportion of female patients increased significantly over time. The type of NTM and patient age were closely associated. Pulmonary NTM isolation was increasingly common with higher age, while extra-pulmonary NTM isolation was mainly seen in small children. Pulmonary NTM IRs were almost twice as high for females in 2008–2022 compared to 1991–2007 (IRR 1.9, 95% confidence interval [CI] 1.7–2.1, p<0.001), with increases mainly seen in older age groups. The increase was less pronounced for males (IRR 1.3, 95%CI 1.1–1.4, p<0.001). There were considerable geographical differences, with age- and sex-adjusted NTM IRs being 10–40% higher in countryside, provincial, and catchment municipalities than in the capital.ConclusionAge, sex, and geography are essential determinants in NTM epidemiology. We found that rates of pulmonary NTM have been increasing, particularly in older females, while changes for males were less pronounced. Finally, we observed considerable geographical differences in NTM IRs in Denmark, with higher rates in less populated municipalities.
Lung recruitment maneouvres strategies in paediatric intensive care units across Europe
Authors: Poletto Elisa , Daverio Marco , Blokpoel Robert George Theodoor , Brigiari Gloria , Gregori Dario , Pons-Odena Marti , Tosoni Alvise 
Published: November 2024

IntroductionIn severe paediatric acute respiratory distress syndrome (PARDS)Lung Recruitment Manoeuvres(LRMs) may be applied to improve oxygenation, but their application is still controversial. The aim of this survey is to report what the current practice is across European PICUs.MethodsOnline survey distributed to PICUs in 19 European countries targeting paediatric intensivists, nurses and respiratory therapists. One reply per unit was allowed.Results151 PICUs out of 276 (54.8%) responded. Of those, 75.9% have more than 300 admissions per year and 45.1% are Extracorporeal Membrane Oxygenation (ECMO) centres. LRMs are employed in 78.9% of surveyed PICUs. Twenty-three out of 105 (21.9%) PICUs have a standardised protocol. LRM are mainly performed by physicians (99%), supported by nurses (38.4%) and/or respiratory therapists (11.5%). The main reported contraindications are air leak (86.7%), hemodynamic instability (75.2%) and intracranial hypertension (63.8%).Staircase Recruitment Manoeuvres (SRMs) are the most commonly (69.5%) practiced LRM while sustained Inflation (SI) is used in 44.8% of PICUs, alone or in addition to SRMs. The success of LRMs is measured through oxygenation improvement (Oxygenation Index or PaO2/FiO2). Profound hypotension is the most reported complication (49.5%), while 35.2% did not report any complication. Lack of familiarity is the main obstacle to the application of LRMs (67.9%).ConclusionsTo our best knowledge this is the first survey providing an overview of current LRMs application among European PICUs. Practise is diverse among countries and PICUs. Further research is necessary to build stronger evidence to support a more standard application of LRMs.
Upregulation of ENAH by a PI3K/AKT/β-catenin cascade promotes oral cancer cell migration and growth via an ITGB5/Src axis
Authors: Chan Xiu-Ya , Chang Kai-Ping , Yang Chia-Yu , Liu Chiao-Rou , Hung Chu-Mi , Huang Chun-Chueh , Liu Hao-Ping , Wu Chih-Ching 
Published: November 2024

Abstract
Background
Oral cancer accounts for 2% of cancer-related deaths globally, with over 90% of cases being oral cavity squamous cell carcinomas (OSCCs). Approximately 50% of patients with OSCC succumb to the disease within 5 years, primarily due to the advanced stage at which it is typically diagnosed. This underscores an urgent need to identify proteins related to OSCC progression to develop effective diagnostic and therapeutic strategies.

Methods
To identify OSCC progression-related proteins, we conducted integrated proteome and transcriptome analyses on cancer tissues from patients and patient-derived xenograft (PDX) model mice. We investigated the role of protein-enabled homolog (ENAH), identified as an OSCC progression-associated protein, through proliferation, transwell migration, and invasion assays in OSCC cells. The mechanisms underlying ENAH-mediated functions were elucidated using gene knockdown and ectopic expression techniques in OSCC cells.

Results
ENAH was identified as a candidate associated with OSCC progression based on integrated analyses, which showed increased ENAH levels in primary OSCC tissues compared with adjacent noncancerous counterparts, and sustained overexpression in the cancer tissues of PDX models. We confirmed that level of ENAH is increased in OSCC tissues and that its elevated expression correlates with poorer survival rates in patients with OSCC. Furthermore, the upregulation of ENAH in OSCC cells results from the activation of the GSK3β/β-catenin axis by the EGFR/PI3K/AKT cascade. ENAH expression enhances cell proliferation and mobility by upregulating integrin β5 in oral cancer cells.

Conclusions
The upregulation of ENAH through a PI3K/AKT/β-catenin signaling cascade enhances oral cancer cell migration and growth via the ITGB5/Src axis. These findings offer a new interpretation of the ENAH function in the OSCC progression and provide crucial information for developing new OSCC treatment strategies.
Chromosome level assemblies of Nakaseomyces (Candida) bracarensis uncover two distinct clades and define its adhesin repertoire
Authors: Marcet-Houben Marina , Księżopolska Ewa , Gabaldón Toni 
Published: November 2024

Abstract
Background
The Nakaseomyces clade is formed by at least nine described species among which three can be pathogenic to humans, namely Nakaseomyces glabratus (Candida glabrata), the second most-common cause of candidiasis worldwide, and two rarer emerging pathogens: Nakaseomyces (Candida) nivarensis and Nakaseomyces (Candida) bracarensis. Early comparative genomics analyses identified parallel expansions of subtelomeric adhesin genes in N. glabratus and N. nivarensis/bracarensis, and suggested possible links with the emergence of the virulence potential in these species. However, as shown for N. glabratus, the proper assessment of subtelomeric genes is hindered by the use of incomplete assemblies and reliance on a single isolate.

Results
Here we sequenced seven N. bracarensis isolates and reconstructed chromosome level assemblies of two divergent strains. We show that N. bracarensis isolates belong to two diverging clades that have slightly different genomic structures. We identified the set of encoded adhesins in the two complete assemblies, and uncovered the presence of a novel adhesin motif, found mainly in N. bracarensis. Our analysis revealed a larger adhesin content in N. bracarensis than previously reported, and similar in size to that of N. glabratus. We confirm the independent adhesin expansion in these two species, which could relate to their different levels of virulence.

Conclusion
N. bracarensis clinical isolates belong to at least two differentiated clades. We describe a novel repeat motif found in N. bracarensis adhesins, which helps in their identification. Adhesins underwent independent expansions in N. glabratus and N. bracarensis, leading to repertoires that are qualitatively different but quantitatively similar. Given that adhesins are considered virulence factors, some of the observed differences could contribute to variations in virulence capabilities between N. glabratus and N. bracarensis.
Multiple skin abscesses due to Nocardia neocaledoniensis: a case report and literature review
Authors: Wang Jun , Chen Taigui , Peng Shijie , Li Lianbao , Wang Liling , Li Jun , He Wei 
Published: November 2024

AbstractN. neocaledoniensis is a very rare infectious pathogen that causes human disease, particularly in immunocompromised individuals. In this case report, we describe the successful diagnosis of N. neocaledoniensis in a patient confirmed by mNGS and the treatment of multiple skin abscesses due to N. neocaledoniensis infection. mNGS is an important diagnostic method complementary to routine bacterial culture and identification methods, especially for rare, novel, co-infected pathogens, and pathogens that are difficult to culture. This report may provide a reference for the clinical treatment and diagnosis of N. neocaledoniensis infection in humans.
Use of biomarkers of metals to improve prediction performance of cardiovascular disease mortality
Authors: Fansler Samuel D. , Bakulski Kelly M. , Park Sung Kyun , Walker Erika , Wang Xin 
Published: November 2024

Abstract
Background
Whether including additional environmental risk factors improves cardiovascular disease (CVD) prediction is unclear. We attempted to improve CVD mortality prediction performance beyond traditional CVD risk factors by additionally using metals measured in the urine and blood and with statistical machine learning methods.

Methods
Our sample included 7,085 U.S. adults aged 40 years or older from the National Health and Nutrition Examination Survey 2003–2004 through 2015–2016, linked with the National Death Index through December 31, 2019. Data were randomly split into a 50/50 training dataset used to construct CVD mortality prediction models (n = 3542) and testing dataset used as validation to assess prediction performance (n = 3543). Relative to the traditional risk factors (age, sex, race/ethnicity, smoking status, systolic blood pressure, total and high-density lipoprotein cholesterol, hypertension, and diabetes), we compared models with an additional 17 blood and urinary metal concentrations. To build the prediction models, we used Cox proportional hazards, elastic-net (ENET) penalized Cox, and random survival forest methods.

Results
420 participants died from CVD with 8.8 mean years of follow-up. Blood lead, cadmium, and mercury were associated (p < 0.005) with CVD mortality. Including these blood metals in a Cox model, initially containing only traditional risk factors, raised the C-index from 0.845 to 0.847. Additionally, the Net Reclassification Index showed that 23% of participants received a more accurate risk prediction. Further inclusion of urinary metals improved risk reclassification but not risk discrimination.

Conclusions
Incorporating blood metals slightly improved CVD mortality risk discrimination, while blood and urinary metals enhanced risk reclassification, highlighting their potential utility in improving cardiovascular risk assessments.