bluuebunny/crossref_metadata_2025_split huggingface dataset:
(249) SHORTER DURATION OF POSTOP IPP INFLATION FOLLOWING MANUAL MODELING MAY LEAD TO CURVATURE REGRESSION
Authors: Gross BL , Gross MS , Madden-Fuentes RJ 
Published: December 2024

Abstract

Introduction
Patients with concomitant erectile dysfunction (ED) and PD are best served by insertion of an inflatable penile prosthesis (IPP) in order to adequately treat both conditions. We elect to leave the IPP inflated postoperatively to maintain curvature reduction improvements, but the ideal duration of postoperative inflation for this purpose has not been determined. There is also little data regarding how the duration of postoperative IPP inflation may affect penile curvature.

Objective
The primary objective was to evaluate how the duration of post-operative IPP inflation may impact changes in penile curvature.

Methods
All IPP patients with known preoperative penile curvature undergoing IPP placement by a single surgeon from January 2017 to June 2023 were included in this IRB-approved (IRB 00031589) retrospective series. All patients received a 3-piece Coloplast Titan Touch IPP (Coloplast, Minneapolis, MN, USA). Goniometer was used to assess curvature during preoperative intracavernosal injection and duplex Doppler ultrasound. All patients followed a standard postoperative follow-up protocol of visits at 2 weeks, 6 weeks and 6 months, although some were also seen sooner than anticipated or with additional unplanned follow-up. Our practice is to leave the device partially (to 60-70%) inflated for2 weeks postoperatively and perform device teaching at 6 weeks postoperatively if feasible. Patients who cannot tolerate device inflation due to pain or other extenuating circumstances are deflated earlier than two weeks. The change in penile curvature, as determined by goniometry at various timepoints, was evaluated relative to the duration of IPP inflation postoperatively.

Results
Sixty-one patients were included. The average preoperative penile curvature was 40° ± 16° (0° to 80°). At the time of surgery, all IPPs were left inflated on average 11 ± 5.2 days with device deflation at &lt;2 weeks for 31.3% patients (n = 19) and at ≥2 weeks for 68.9% patients (n = 42). There was no curvature regression for either group at 2 weeks or 6 months; however, both groups had a subset of patients with worsened curvature at 6 weeks. Penile curvature was worse at 6 weeks for 26.3% (n = 5) of patients with a shorter IPP inflation period compared to 12.8% (n = 5) of patients with device inflation of at least two weeks.

Conclusions
Patients with IPP deflation &lt;2 weeks had a higher incidence of curvature regression 6 weeks postoperatively compared to patients with IPP deflation ≥2 weeks. Curvature did not regress while device was inflated or between the 6 week and 6 month postoperative visits. Additional studies are needed to elucidate the optimal timeframe for, and degree of, IPP inflation to avoid postoperative penile curvature regression.

Disclosure
Any of the authors act as a consultant, employee or shareholder of an industry for: Coloplast, MenMD.
(251) ATYPICAL HORMONAL PROFILE AND POST-TREATMENT SEXUAL HEALTH CHALLENGES IN A YOUNG PATIENT WITH NON-SEMINOMATOUS TESTICULAR GERM CELL CARCINOMA
Authors: Souza L , Sousa L , Freire M , Moura D , Araujo F , Barretto N 
Published: December 2024

Abstract

Introduction
Non-seminomatous testicular germ cell carcinoma (NSTGCC) is a complex pathological entity known for its aggressiveness and metastatic potential, primarily affecting young men. The association of this tumor with specific hormonal changes, such as abnormal testosterone levels, underscores the importance of detailed evaluations in these patients.

Objective
To describe a case of a young patient who exhibited an atypical hormonal profile with elevated testosterone levels before a surgical intervention for NSTGCC, but post-treatment, despite normal testosterone levels, reported abnormal sexual quality of life.

Methods
This case study involved a detailed review of the patient’s medical history, physical examinations, laboratory analyses of hormones (Testosterone, LH, FSH), imaging (testicular ultrasound), and histopathological findings from the tumor after a left unilateral radical orchiectomy. Additionally, a literature review was conducted to compare these findings with existing reports, focusing on NSTGCC and its association with hormonal changes, as well as clinical management post-oncological treatment.

Results
Before surgical intervention, the patient exhibited an atypical hormonal profile with elevated testosterone levels (1556.51 ng/dL) and suppressed LH and FSH, without using exogenous testosterone. Post-orchiectomy and chemotherapy, LH and FSH levels normalized, and testosterone levels decreased to normal (495.0 ng/dL). Post-treatment, the patient experienced normal testosterone levels but reported erectile dysfunction and a significant reduction in quality of life. Considering the patient prior sperm cryopreservation and the urgent need to address changes in his sexual health, treatment with exogenous testosterone (deposteron 200 mg, one intramuscular ampoule every 14 days) was initiated. The patient now reports improved sexual quality of life and satisfaction with the therapeutic effects.

Conclusions
This case highlights the complexity of NSTGCC and the critical role of monitoring hormonal levels before and after treatment. The normalization of hormonal levels post-treatment underscores the necessity for individualized management, as these results do not always correlate with the patient’s quality of life, thereby optimizing therapeutic and prognostic outcomes. It also emphasizes the need for further studies on the clinical management of NSTGCC patients to enhance existing procedures and improve their quality of life and psychosocial well-being.

Disclosure
No.
(270) WORLDWIDE INTEREST IN TESTOSTERONE REPLACEMENT THERAPY
Authors: Lumbiganon S , Hammad M , Abou Chawareb E , Azad B , Miller J , Lee J , Yafi F 
Published: December 2024

Abstract

Introduction
Testosterone replacement therapy (TRT) has garnered substantial attention in recent years as a potential solution to various health concerns associated with low testosterone levels. TRT addresses symptoms ranging from low energy and libido to muscle loss and mood disturbances. Interest in TRT varies across different geographical regions, and comprehending these distinctions may assist healthcare providers in tailoring the appropriate use of TRT.

Objective
This study aims to assess global interest in testosterone replacement therapy and explore its correlation with available health-related and socioeconomic data.

Methods
Google Trends was employed to gauge online-based public interest in TRT. The data from various countries were ranked and compared using correlation statistics with health-related and socioeconomic data from the World Health Organization and the World Bank.

Results
Interest in TRT, as indicated by Google Trends, has experienced a consistent increase over the past five years. The top five countries with the highest levels of interest were the United States, Australia, Canada, New Zealand, and the United Kingdom, respectively. Positive correlations were identified between the rank of TRT interest for each country and government healthcare expenditure (R = 0.517, 95%CI; 0.211, 0.731) as well as gross domestic product per capita (R = 0.581, 95%CI; 0.286, 0.776). However, there was no significant correlation between TRT interest and population life expectancy (R = 0.229, 95%CI −0.130, 0.535), the percentage of the population with internet accessibility (R = 0.225, 95%CI; −0.102, 0.555), density of medical doctors per population (R = 0.096, 95%CI; −0.261, 0.430), or the WHO universal health coverage index (R = 0.314, 95%CI; −0.039, 0.598).

Conclusions
The analysis reveals a rising trend of interest in TRT, particularly in countries with higher GDP and greater government healthcare expenditure. This heightened interest may be attributed to improved economic status and increased healthcare spending. These findings can inform healthcare policy implementation based on each country’s income level and facilitate the monitoring of inappropriate TRT usage within individual countries.

Disclosure
No.
(282) IN THE EYES OF PATIENTS COMPLAINING OF PREMATURE EJACULATION, WHAT ARE THE NORMAL INTRAVAGINAL EJACULATION LATENCY TIME (IELT) AND EXPECTED IELT?
Authors: Wang C , Colonnello E , Sansone A , Zhang H , Zhu D , Jannini EA , Zhang Y 
Published: December 2024

Abstract

Introduction
Although the normal intravaginal ejaculation latency time (NIELT) in the eyes of patients with premature ejaculation (PE) and expected intravaginal ejaculation latency time (EIELT) are critically influential in the treatment of patients with PE, there is a significant dearth of exploratory research on these clinical parameters among patients with PE.

Objective
To explore the NIELT and EIELT of patients with PE, understand why patients with PE perceive such a long IELT as normal, and identify factors associated with EIELT.

Methods
We recruited both patients with PE and controls and administered questionnaires to gather data relevant to the research objectives.

Results
A total of 592 individuals (mean age 29.6 ± 6.2) were included in the study, comprising 466 patients with PE (mean age 28.3 ± 5.4) and 126 controls without PE (mean age 34.6 ± 6.5). The actual perceived IELT (PIELT), NIELT, and EIELT of patients with PE were 1.0 (1.0–2.0), 14.0 (10.0–15.0), and 15.0 (10.0–20.0), respectively, with a p-value &lt;0.001. Among patients with PE, 51.3% expressed a NIELT &gt;10 minutes, identical to the EIELT in a higher percentage (59.4%). Reasons why patients with PE perceived such long IELT as normal included self-perception (42.5%), online sources (21.0%), advice from friends (11.4%), information from sexual partners (8.2%), exposure to pornography (7.5%), and other sources (9.4%). Among various factors, NIELT accounted for the greatest extent of variability in EIELT (beta = 0.817, P &lt; 0.001).

Conclusions
Patients with PE often have excessively high expectations regarding IELT, primarily due to their insufficient understanding of IELT. Sexual health care providers should provide comprehensive sexual education to patients with PE and strive to normalize their expectations of IELT, thereby enhancing their satisfaction with treatments, which is still a significant problem in PE management. Furthermore, the dissemination of these research findings to the public can promote a correct understanding of IELT, aligning people’s expectations with reality and mitigating sexual disappointment.

Disclosure
Any of the authors act as a consultant, employee or shareholder of an industry for: EAJ is or has been paid consultant and/or paid speaker for Bayer, Ibsa, Menarini, Otsuka, Pfizer, Viatris.
(304) CORRELATION BETWEEN PENILE STRETCH LENGTH AND ERECT LENGTH OF VIETNAMESE MEN: A PROSPECTIVE STUDY
Authors: Ho P , Nguyen AT , Pham TMH , Nguyen THT , Pham MN , Nguyen THH 
Published: December 2024

Abstract

Introduction
Erect penis length plays an important role in the sexual confidence and sexual life of men. However, there was some difficulty in measuring the exact erection length while doing the clinical examination. Men who come for examination at our hospital in Vietnam are diverse in ages, geographical areas, and occupations. Clinical examination of male genitalia includes the penis and testicles as the two most important components. During the penile examination, assessment of the patient’s penis length at the time of examination reflects characteristics related to fertility and sexual function and contributes to diagnosis and prognosis. Moreover, there have not been many studies on penis size that fully evaluate measurements of flaccid, stretched, and erection. There were some studies about the average erect penile length in Europe and America, but there are have been no study studies in Vietnamese in recent years. In clinical practice, we also use stretch penile length to evaluate the erection length indirectly, but is there a correlation between them in the Asian men group or our report Vietnamese men?

Objective
To determine the correlation between penile length measured when stretched and erection.

Methods
Three hundred eight men who visited our hospital in Hanoi, Viet Nam were involved in our study between December 2022 and December 2023. The age, geographical areas, and occupations of the subjects were recorded. Penile measurements (flaccid, erect length, stretched length) were predominantly taken by one investigator using a tape measure and the same measurement technique. STATA version 17.0 was used for statistical evaluation of the results. Results were evaluated using descriptive statistics and Pearson correlation analysis between penile flaccid, erect length, stretched length parameters, p value less than 0.05 was considered significant.

Results
The mean age of the subjects was 28 (range: 15-55) years. Men from big urban areas (Ha Noi, Hai Phong, Ho Chi Minh City) had the most visits (29,9%). Nearly 3% of participants had circumcision. It accounted for 55,2% of freelancers and businessmen who were consulted. The mean penile length in flaccid, stretched and erection states were 9.41 ± 1.75 cm, 12.75 ± 1.73 cm, and 13.43 ± 1.53 cm, respectively. Mean penile length were not significantly different between ages, geographical area, and occupation (p &gt; 0.05). There was a positive correlation between stretch length and erection length (r = 0.73, p &lt; 0.05); with the equation of erect length = 13.34 + 0.01x stretched length.

Conclusions
Our study provides fully evaluate measurements of flaccid, stretched, and erection in Vietnamese men and there was a positive correlation between stretch length and erection length. So we suggest using stretch penile length to evaluate erection length in our clinical practice.

Disclosure
No.
Contribution of the main contaminating materials during pig slaughter to the microbial numbers on carcasses
Authors: Tholen Janna , Upmann Matthias 
Published: December 2024

Abstract
During pig slaughter, contaminants such as intestinal and stomach contents, bile, tubular rail fat, and reddish foam from the respiratory tract frequently appear on carcasses, potentially compromising meat safety. This study examined the impact of these contaminants on the bacterial loads of pig carcasses, using total bacterial counts and Enterobacteriaceae counts as hygiene indicators. Examination of the substances as such showed that intestinal and stomach contents were particularly conspicuous to undermine the carcase hygiene due to total bacterial counts of ∼6.0 log10 CFU g−1 (intestinal content) and 5.5 log10 CFU g−1 (stomach content). Tubular rail fat showed varying contamination levels, from low (3.1 log10 CFU g−1) to high (6.4 log10 CFU g−1). The reddish foam had moderate contamination (4.3 log10 CFU g−1). Enterobacteriaceae levels mirrored these results at a lower level. Subsequently, a comparative study analysing bacterial levels in contaminated and in noncontaminated pork rind regions was performed. Even small amounts of intestinal and stomach contents led to significant increases in total bacterial counts of up to 3 log10 CFU cm−² and in Enterobacteriaceae counts (up to 5 log10 CFU cm−²). Other contaminants did not significantly raise bacterial levels: their total viable counts around 3.5 log10 CFU cm−² were similar to those of uncontaminated carcass areas. Nevertheless, they should be removed before further processing.
Modulation of physiological functions and metabolome of Vibrio alginolyticus by quorum-regulatory sRNA, Qrr1
Authors: Zhao Yanni , Wu Ruobing , Wu Xuan , Zhou Ningning , Ren Jiamin , Liu Wang , Yu Rui , Zhang Senhu , Yang Jinfang , Li Hua , Liu Huan 
Published: December 2024

Abstract
Vibrio alginolyticus, the causative agent of aquatic vertebrates and invertebrates, can cause severe infections (e.g. septicemia, gill necrosis, and surface ulcers) and high mortality in aquatic organisms, leading to serious economic losses in global aquaculture. Small non-coding RNAs (sRNAs), emerging modulators of gene expression, played vital regulatory roles in virulence, pathogenicity, and physiological metabolism of bacteria. In this work, the modulation of physiological functions and metabolome of V. alginolyticus by the quorum-regulatory sRNA, Qrr1, was figured out. We found that the deletion of qrr1 induced significant cell shape elongation. Meanwhile, Qrr1 could inhibit the production of alkaline serine protease by weakening the expression of main regulator LuxR in the quorum sensing (QS) system. Moreover, the untargeted metabolomics and lipidomics approaches showed that most of nucleotides, organic acids, carbohydrates, and lipidome (both lipid content and category) were significantly altered in response to the qrr1 deletion. Spearman correlation analysis demonstrated that most of the intermediates involved in glutamate metabolism, sphingolipid metabolism, and glycerolipid metabolism displayed high correlations with cell virulence factors. These findings illuminate the mechanism of bacterial virulence regulation and further exploit potential therapeutic targets for virulence prevention in V. alginolyticus.
Introduction
Authors: Derham Rory 
Published: December 2024

Abstract
This chapter introduces the key concept of set-off. Despite the difficulty of a comprehensive definition without reference to the various forms it takes, a set-off is generally defined as the setting of money cross-claims against each other to produce a balance. Additionally, set-off provides a defence to an action, although, depending on the form of set-off, the issue need not arise in that context. The chapter then elaborates on the importance of set-off that revolves around insolvency, counterclaims, costs, third party interests, and arbitration. It then details the forms of set-off and civil procedures rules as per the Civil Procedure Rules 1998
Mutuality: Introduction
Authors: Derham Rory 
Published: December 2024

Abstract
This chapter provides an overview of mutuality. It highlights that, under the Statutes of Set-off, there must be mutuality for both insolvency set-off and set-off. Essentially, mutuality does not require that the claims should arise at the same time, nor that there should be any connection between them. However, claims may have a different nature since the notion of mutuality conveys reciprocity instead of correspondence. Additionally, mutuality needs commensurable cross-demands between the same parties and that they are held in the same capacity, right, or interest. The chapter examines the general principles of equitable interests and the correlation of mutuality to set-off under the Statutes of Set-off.
Mutuality: Same Right
Authors: Derham Rory 
Published: December 2024

Abstract
This chapter explains the requirement that the demands be held in the same right in the case of insolvency set-off. It cites that each of the parties to a proposed set-off must be both personally liable to the other and the beneficial owner of a cross-demand against the other. The Statutes of Set-off contemplate mutuality as reference to the legal title of the debts. However, equity may allow a set-off by analogy with the Statues if there is mutuality in equity but not in law. The chapter considers the requirement of mutuality in correlation with personal capacities, trustees in bankruptcy, and the effect of company liquidation.
Combination of Bank Accounts
Authors: Derham Rory 
Published: December 2024

Abstract
This chapter discusses the circumstances wherein a customer has more than one account with a bank. It highlights the bank’s power to combine, or consolidate, the accounts and proceed on the basis that there is only one debt for the balance. Combination is important if the bank is suspicious of the customer’s solvency because it provides the bank with a means to obtain the benefit of the account in credit, by setting it against the debit account before the customer dissipates the credit balance. The chapter then provides an overview of the nature of the right of combination. It also considers the criticisms surrounding the combination since it was considered to be inconsistent with many of the features of bank accounts.
Chemically peculiar stars as members of open clusters
Authors: Faltová N , Jadlovský D , Kueß L , Labaj M , Mesarč M , Mondal P , Neumannová K , Paunzen E , Prišegen M , Ramezani T , Supíková J , Svačinková K , Szász G , Vítková M , Xia C 
Published: December 2024

ABSTRACT
The chemically peculiar (CP) stars of the upper main sequence are excellent astrophysical laboratories to test the diffusion, mass-loss, rotational mixing, and pulsation in the (non-)presence of a stable local magnetic field. These processes are time-dependent. The age estimation of Galactic field stars suffers from several limitations. Therefore, studying members of star clusters overcomes these difficulties. We matched the most recently published catalogues of star clusters and CP stars. For the matching, we used the newest Gaia Data Release. We also used the $\Delta$a photometry tool to further distinguish between the CP subgroups. We found 595 CP stars in 408 star clusters of all ages. Furthermore, we report on misclassified metallic line stars (Am or CP1) and objects with no CP classification. The distribution of magnetic and non-magnetic CP stars on the main sequence seems different. We do not detect very young and very old CP stars showing rotationally induced variability. CP members of star clusters help to study all relevant processes responsible for this phenomenon in more detail. Still, a larger sample is desired to put tighter constraints on models.
Metallicity of RR Lyrae stars from the Gaia Data Release 3 catalogue computed with Machine Learning algorithms
Authors: Muraveva Tatiana , Giannetti Andrea , Clementini Gisella , Garofalo Alessia , Monti Lorenzo 
Published: December 2024

ABSTRACT
We present new $P -\phi _{31}-{\rm [Fe/H]}$ and $P -\phi _{31}- A_2 - {\rm [Fe/H]}$ relations for fundamental mode (RRab) and first-overtone mode (RRc) RR Lyrae stars (RRLs), respectively. The relations were calibrated based on pulsation periods and Fourier parameters of the RRL light curves in the GaiaG-band published in the Gaia Data Release 3 (DR3), and accurate spectroscopically measured metallicities available in the literature. We apply the feature selection algorithm to identify the most relevant parameters for the determination of metallicity. To fit the relations, we used the Bayesian approach, which allowed us to carefully take into account uncertainties in various parameters and the intrinsic scatter of the relations. The root mean squared errors of the predicted metallicity values in the training samples are 0.28 and 0.21 dex for RRab and RRc stars, respectively, comparable with the typical uncertainty of low/intermediate resolution spectroscopic metallicity measurements. We applied the new relations to measure individual metallicities and distances to $\sim$134 000 RRLs from the Gaia DR3 catalogue, as well as mean metallicities and distances to 38 Milky Way globular clusters. We also estimate the mean metallicity and distance to the Large Magellanic Cloud and Small Magellanic Cloud: ${\rm [Fe/H]_{LMC} = -1.63\pm 0.36}$ and $\mu _{\rm LMC}=18.55\pm 0.18$ mag, and ${\rm [Fe/H]_{SMC}=-1.86\pm 0.36}$ dex and $\mu _{\rm SMC}=19.01\pm 0.17$ mag, respectively, in excellent agreement with previous measurements.