bluuebunny/crossref_metadata_2025_split huggingface dataset:
One‐year clinical outcomes and multislice computed tomography angiographic results following implantation of theNeoVas bioresorbable sirolimus‐eluting scaffold in patients with single de novo coronary artery lesions
Authors: Wang Xiao‐Zeng , Zhang Yao‐Jun , Fu Guo‐Sheng , Jing Quan‐Min , Xu Bo , Han Ya‐Ling 
Published: February 2018

AbstractBackgroundTremendous efforts have been made to establish the concept of vascular restoration therapy with a fully bioresorbable scaffold for coronary artery disease. With an improved scaffold design and technologies, the novel NeoVas scaffold has shown promising clinical performance at 6 months follow‐up.ObjectiveThe aim of this study was to investigate the 1 year clinical outcomes and multislice computed tomography (MSCT) angiographic results after implantation of the NeoVas scaffold in patients with single de novo coronary artery lesions.MethodsThe NeoVas first‐in‐man study was a prospective, two‐center, single‐arm study enrolling 31 patients who were eligible for the treatment. The composite endpoint of target lesion failure (TLF)—defined as cardiac death, target vessel myocardial infarction, and clinically indicated target lesion revascularization (TLR)—was assessed. Of the 31 patients scheduled for 1 year clinical follow‐up, 29 patients received MSCT examinations.ResultsAt 1 year follow‐up, there was only 1 (3.2%) TLF, attributed to 1 patient who suffered ischemia‐driven TLR at 181 days postprocedure. No cardiac deaths or scaffold thrombosis were observed. MSCT analysis demonstrated excellent vessel patency, with a median in‐scaffold lumen area of 10.6 mm2(interquartile range [IQR]: 8.2–11.7 mm2) and a minimal lumen diameter of 2.7 mm (IQR: 2.4–3.0 mm).ConclusionsThis study demonstrated the safety and efficacy of the NeoVas scaffold for patients with single de novo coronary artery lesions at 1 year of follow‐up. Noninvasive MSCT data confirmed vessel patency and the maintenance of vessel dimensions following implantation of the NeoVas bioresorbable sirolimus‐eluting scaffold.
Direct Production of Iso‐Paraffins from Syngas over Hierarchical Cobalt‐ZSM‐5 Nanocomposites Synthetized by using Carbon Nanotubes as Sacrificial Templates
Authors: Flores Camila , Batalha Nuno , Ordomsky Vitaly V. , Zholobenko Vladimir L. , Baaziz Walid , Marcilio Nilson R. , Khodakov Andrei Y. 
Published: February 2018

AbstractThis paper focuses on the effect of synthesis conditions on the structure of cobalt‐ZSM‐5 zeolites and the localization, dispersion, and reducibility of cobalt species and their catalytic performance in Fischer–Tropsch synthesis. The zeolite catalysts were prepared by using carbon nanotubes as sacrificial templates. Addition of pristine carbon nanotubes resulted only in a slight increase in the zeolite mesoporosity, whereas the presence of carbon nanotubes impregnated with cobalt drastically modified the zeolite morphology and texture. The zeolite mesoporous volume increased by 3–4 times. The catalysts prepared by using cobalt‐impregnated carbon nanotubes as templates showed 5–8 times higher Fischer–Tropsch reaction rates normalized by reducible cobalt compared with the catalysts prepared by conventional impregnation. Higher selectivity to isomerized branched hydrocarbons on these zeolites was attributed to the enhanced diffusion favoring removal of isomerized products and avoiding their cracking.
Pluronic‐Conjugated Enzyme Cascade for In Situ Oxidation in Biphasic Media
Authors: Wang Zheyu , Xu Weina , Fu Zhongwang , Jiang Guoqiang , Wu Jianzhong , Liu Zheng 
Published: February 2018

AbstractA Pluronic‐conjugated enzyme cascade was synthesized for catalyzing oxidation reactions using hydrogen peroxide (H2O2) as the oxidant. The synthesis started with encapsulating enzymes in the micelles of aldehyde‐functionalized Pluronic (PL) containing bovine serum albumin (BSA). Schiff‐base bonds formed between the amine groups of proteins and the aldehyde groups of the PL, which were reduced to a more stable form, resulting in enzyme–PL conjugates. The effects of operation parameters on the conjugate yield were examined using glucose oxidase (GOx) and horseradish peroxidase (HRP) as examples. The co‐localization of GOx and HRP was confirmed by Förster resonance energy transfer (FRET), from which the average distance between GOx and HRP was interpreted as 6.1 nm. The proximity effect was confirmed by adding a high concentration of catalase (CAT) to a solution of GOx–HRP–PL to catalyze the oxidation of ABTS. The GOx–HRP–PL conjugate was readily solubilized in organic solvents such as dimethyl sulfoxide, methanol or chloroform. Phenol oxidation with GOx–HRP–PL in dimethyl sulfoxide/water biphasic media was conducted using glucose as the substrate to generate H2O2 in situ. The multiple enzyme conjugate provided a 1.3‐fold higher removal rate compared to their native counterparts in free form. The GOx–HRP–PL conjugate could be readily recovered by centrifugation at 4 °C and 90 % of the initial activity remained after 10 cycles.
Ultrapermeable Nickel–Cobalt–Manganese/Alumina Inverse Opal as a Coke‐Tolerant and Pressure‐Drop‐Free Catalyst for the Dry Reforming of Methane
Authors: Kim Won Yong , Lee Byung Jun , Park Hunmin , Choi Yo Han , Kim Ju Hun , Lee Jae Sung 
Published: February 2018

AbstractAn inverse opal‐structured Ni‐Co‐Mn/Al2O3 catalyst with ultrahigh permeability was prepared by a sol–gel method templated by poly(methyl methacrylate) opal‐structured nanospheres. This catalyst exhibited excellent coke tolerance and a negligible reactor pressure drop in the dry reforming of methane. The highly permeable, unique macroporous structure allowed facile mass transport, which not only reduced the amount of coke deposition but also enhanced coke tolerance. Therefore, invariant CO2/CH4 conversions despite substantial coke formation were observed.
Synthesis of a Novel Type of 2,3′‐BIMs via Platinum‐Catalysed Reaction of Indolylallenes with Indoles
Authors: Cooper Lisa , Alonso José Miguel , Eagling Louise , Newson Helen , Herath Sachini , Thomson Christopher , Lister Andrew , Howsham Catherine , Cox Brian , Muñoz María Paz 
Published: February 2018

AbstractOptimisation, scope and mechanism of the platinum‐catalysed addition of indoles to indolylallenes is reported here to give 2,3′‐BIMs with a novel core structure very relevant for pharmaceutical industry. The reaction is modulated by the electronic properties of the substituents on both indoles, with the 2,3′‐BIMs favoured when electron donating groups are present. Although simple at first, a complex mechanism has been uncovered that explains the different behaviour of these systems with platinum when compared with other metals (e.g. gold). Detailed labelling studies have shown Pt‐catalysed 6‐endo‐trig cyclisation of the indollylallene as the first step of the reaction and the involvement of two cyclic vinyl‐platinum intermediates in equilibrium through a platinum carbene, as the key intermediates of the catalytic cycle towards the second nucleophilic attack and formation of the BIMs.
Effects of C‐Related Dangling Bonds and Functional Groups on the Fluorescent and Electrochemiluminescent Properties of Carbon‐Based Dots
Authors: Wang Min , Sun Ruifen , Wang Qian , Chen Lichan , Hou Linxi , Chi Yuwu , Lu Chun Hua , Fu Fengfu , Dong Yongqiang 
Published: February 2018

AbstractSingle‐layer carbon‐based dots (SCDs) were chosen as a model to investigate the effect of the C‐related dangling bonds with spin S=1/2 and functional groups on the electrochemiluminescent (ECL) and fluorescent (FL) properties of CDs. The C‐related dangling bonds and functional groups of SCDs were tuned by chemical reduction with NaBH4. There have several main findings via investigating the ECL and FL properties of SCDs before and after the chemical reduction. First, the FL and ECL of CDs are highly dependent on their concentration, and luminescent resonance energy transfer is observed in ECL studies when the concentration of CDs is high. Second, the ECL activity of CDs is greatly enhanced as the C‐related dangling bonds increase, proving that the ECL of CDs originates from the C‐related dangling bonds. Third, the FL of CDs is the synthesis of the inner FL originated from the contained isolated sp2 units and the defect FL from the C‐related dangling bonds. The inner FL of CDs is enhanced greatly by removing the carboxyl groups, while the defect FL is increased slightly due to the increased C‐related dangling bonds. We believe this study would promote our understanding in the ECL and FL mechanisms of CDs, advancing the applications of CDs based on their ECL and FL properties.
Racial disparities in preoperative chemotherapy use in gastric cancer patients in the United States: Analysis of the National Cancer Data Base, 2006‐2014
Authors: Ikoma Naruhiko , Cormier Janice N. , Feig Barry , Du Xianglin L. , Yamal Jose‐Miguel , Hofstetter Wayne , Das Prajnan , Ajani Jaffer A. , Roland Christina L. , Fournier Keith , Royal Richard , Mansfield Paul , Badgwell Brian D. 
Published: February 2018

BACKGROUNDNo studies have investigated whether race/ethnicity is associated with the recommended use of preoperative chemotherapy or subsequent outcomes in gastric cancer. To determine whether there is such an association, analyses of patients with gastric cancer in the National Cancer Data Base (NCDB) were performed.METHODSPatients with clinical T2‐4bN0‐1M0 gastric adenocarcinoma, as defined by the eighth edition of the American Joint Committee on Cancer staging manual, who underwent gastrectomy from 2006 to 2014 were identified from the NCDB. Multiple logistic regression was conducted to examine factors associated with preoperative chemotherapy use.RESULTSThis study identified 16,945 patients who met the criteria, and 8286 of these patients (49%) underwent preoperative chemotherapy. The use of preoperative chemotherapy remarkably increased over the study period, from 34% in 2006 to 65% in 2014. Preoperative chemotherapy was more commonly used for cardia tumors than noncardia tumors (83% vs 44% in 2014). In a multivariable analysis, races and ethnicities other than non‐Hispanic (NH) white race were associated with less frequent use of preoperative chemotherapy in comparison with NH whites after adjustments for social, tumor, and hospital factors. The insurance status and the education level mediated an enhanced effect of racial/ethnic disparities in preoperative chemotherapy use. The use of preoperative chemotherapy and radiation therapy was associated with reduced racial/ethnic disparities in overall survival.CONCLUSIONSRacial/ethnic disparities in the use of preoperative chemotherapy and in outcomes exist among patients with gastric cancer in the United States. Efforts to improve the access to high‐quality cancer care in minority groups may reduce racial disparities in gastric cancer in the United States. Cancer 2018;124:998‐1007. © 2018 American Cancer Society.
Color appearance of afterimages compared to the chromatic adaptation to illumination
Authors: Phuangsuwan Chanprapha , Ikeda Mitsuo , Mepean Janjira 
Published: February 2018

AbstractThe color appearance of negative afterimages was measured by the elementary color naming method, and the results were compared with those obtained by the two‐room technique. Twenty adapting stimuli were presented on a display sequentially. Subjects first assessed the color appearance of the stimuli. After looking at the adapting stimulus for 10 seconds, the subjects assessed color of the afterimage. Apparent hue of the afterimage was in general not opponent color to the adapting color. The relation between the adapting stimuli and the afterimages was analyzed by the angle difference Δθ, when apparent hues are expressed by the angles of the points on the polar diagram of the opponent color theory. The relation relationship of Δθ to the angle of the adapting color θing was quite similar to the results obtained by the two‐room technique, implying that the chromatic adaptation shown by the afterimage also occurs in the brain rather than in the retina.
Pharmacokinetic Evaluation of Two Nicotine Patches in Smokers
Authors: Rasmussen Scott , Horkan Kathleen Halabuk , Kotler Mitchell 
Published: February 2018

AbstractSmoking continues to be a major preventable cause of early mortality worldwide, and nicotine replacement therapy has been demonstrated to increase rates of abstinence among smokers attempting to quit. Nicotine transdermal systems (also known as nicotine patches) attach to the skin via an adhesive layer composed of a mixture of different‐molecular‐weight polyisobutylenes (PIBs) in a specific ratio. This randomized, single‐dose, 2‐treatment, crossover pharmacokinetic (PK) trial assessed the bioequivalence of nicotine patches including a replacement PIB adhesive (test) compared with the PIB adhesive historically used on marketed patches (reference). The test and reference patches were bioequivalent, as determined by the PK parameters of Cmax and AUC0–t. In addition, the parameters Tmax and t1/2 did not significantly differ between the 2 patches, supporting the bioequivalence finding from the primary analysis. The tolerability profiles of the patches containing the replacement and previously used PIB adhesives were similar; application‐site adverse events did not significantly differ between test and reference patches. Overall, these data establish the bioequivalence of the nicotine patch with the replacement PIB adhesive formulation and the previously utilized PIB adhesive formulation.
Identifying Different Halogen‐/Hydrogen‐Bonding Interaction Modes in Binary Systems that Contain an Acetate Ionic Liquid and Various Halobenzenes
Authors: Xu Jing , Zhou Yu , Deng Geng , Ashraf Hamad , Yu Zhi‐Wu 
Published: February 2018

AbstractElucidation of the nature of noncovalent interactions between ionic liquids (ILs) and halogenated molecules is of particular importance for both fundamental research and drug development. Herein, the noncovalent interactions between 1‐butyl‐3‐methyl‐imidazolium acetate and three halobenzenes C6F5X (X=I, Br, H) were investigated. The iodine derivative shows the strongest interaction with the IL, followed by C6F5Br and C6F5H. As indicated by the positive/negative peaks and “multi/two‐state” phenomena in the excess IR spectra, combined with DFT calculations, various interaction modes were differentiated. Three complexes, namely anion–C6F5I, anion–2 C6F5I, and ion‐pair–C6F5I in the IL–C6F5I system were identified, whereas only ion‐pair–C6F5Br/C6F5H complexes, together with self‐associates, were found in the other two systems. A possible reason for the behavior of the IL–C6F5I system could be that the iodine‐based halogen‐bonding interactions in the system are strong enough to break interactions between the IL cations and anions. This might make C6F5I a good co‐solvent to regulate the properties of acetate‐based ILs.
Square partition‐based node scheduling algorithm for wireless passive sensor networks
Authors: Lu Xu , Chen Rongjun , Liu Jun , Cheng Lianglun 
Published: February 2018

SummaryWireless passive sensor networks play an important role in solving the energy limitation of nodes in the Internet of Things, and node scheduling is a significant method used to improve the energy utilization of nodes. In this work, an unused energy model based on analyzing the energy consumption characteristics of passive nodes is proposed because no unified model of passive sensor nodes is reported in previous studies. A rapid square partition clustering method is proposed according to the analysis of the relation between the sensing and communication radii of nodes, and the secondary grouping and node scheduling in each cluster are implemented to ensure the coverage rate of networks. Experimental results show that the state distribution of nodes in the proposed algorithm is favorable. The performance of the proposed algorithm is significantly affected by the P ratio between the working and charging powers of nodes. When the value of P is less than 100, the network coverage and connectivity rate are maintained at more than 95% and 90%, respectively, and are both higher than the existing algorithm.
Ten‐year weight gain is associated with elevated fasting insulin levels and precedes glucose elevation
Authors: Pennings Nicholas , Jaber Johnny , Ahiawodzi Peter 
Published: February 2018

AbstractBackgroundNumerous studies have examined the relationship between endogenous insulin and weight change with mixed results. This study examined the relationship between fasting insulin levels, insulin resistance (IR), and 10‐year weight change by glycaemic stage.MethodsUsing data from the US National Health and Nutrition Examination Survey 2011‐2014, 3840 participants were divided into 6 groups based on fasting glucose and fasting insulin levels. Fasting insulin concentrations were dichotomized into <25th percentile (normal) and ≥25th percentile (elevated). Ten‐year weight change associated with fasting insulin was assessed by glycaemic stage.ResultsAverage weight change over a 10‐year period was higher in individuals with elevated insulin levels compared to the first quartile (1.40 lbs. vs 11.12 lbs, P < .0001). Across all groups, a 1 μU increase in fasting insulin levels resulted in a 0.52‐pound increase in weight (P < .0001). Similarly, an increase in HOMA‐IR was associated with increase in weight (1.32 lbs per IR unit, P < .0001). Marginal increases in weight were most pronounced in the normal insulin groups compared to elevated insulin groups and diminished as glycaemic stage progressed.ConclusionsElevated fasting insulin level was positively associated with weight gain. The impact of fasting insulin and IR on weight gain preceded hyperglycaemia and diminished as glycaemic stage progressed.
Physiological and pathological characterization of capsaicin‐induced reversible nerve degeneration and hyperalgesia
Authors: Chiang H. , Chang K.‐C. , Kan H.‐W. , Wu S.‐W. , Tseng M.‐T. , Hsueh H.‐W. , Lin Y.‐H. , Chao C.‐C. , Hsieh S.‐T. 
Published: February 2018

AbstractBackgroundThe study aimed to investigate the physiology, psychophysics, pathology and their relationship in reversible nociceptive nerve degeneration, and the physiology of acute hyperalgesia.MethodsWe enrolled 15 normal subjects to investigate intraepidermal nerve fibre (IENF) density, contact heat‐evoked potential (CHEP) and thermal thresholds during the capsaicin‐induced skin nerve degeneration–regeneration; and CHEP and thermal thresholds at capsaicin‐induced acute hyperalgesia.ResultsAfter 2‐week capsaicin treatment, IENF density of skin was markedly reduced with reduced amplitude and prolonged latency of CHEP, and increased warm and heat pain thresholds. The time courses of skin nerve regeneration and reversal of physiology and psychophysics were different: IENF density was still lower at 10 weeks after capsaicin treatment than that at baseline, whereas CHEP amplitude and warm threshold became normalized within 3 weeks after capsaicin treatment. Although CHEP amplitude and IENF density were best correlated in a multiple linear regression model, a one‐phase exponential association model showed better fit than a simple linear one, that is in the regeneration phase, the slope of the regression line between CHEP amplitude and IENF density was steeper in the subgroup with lower IENF densities than in the one with higher IENF densities. During capsaicin‐induced hyperalgesia, recordable rate of CHEP to 43 °C heat stimulation was higher with enhanced CHEP amplitude and pain perception compared to baseline.ConclusionsThere were differential restoration of IENF density, CHEP and thermal thresholds, and changed CHEP–IENF relationships during skin reinnervation. CHEP can be a physiological signature of acute hyperalgesia.SignificanceThese observations suggested the relationship between nociceptive nerve terminals and brain responses to thermal stimuli changed during different degree of skin denervation, and CHEP to low‐intensity heat stimulus can reflect the physiology of hyperalgesia.
Latest advances in the extraction and determination of saffron apocarotenoids
Authors: Kyriakoudi Anastasia , Z. Tsimidou Maria 
Published: February 2018

AbstractSaffron, the dried red stigmas of Crocus sativus L. plant, is the most expensive spice in the world. It is highly valued not only for the color and flavor that exerts to various foods and drinks but also for its functional properties. Various classes of apocarotenoids such as crocetin sugar esters, picrocrocin and safranal are responsible for these characteristics. In the present review, the evolution of the methods proposed by the ISO standard for extraction and determination of saffron apocarotenoids since 1980 is presented in parallel to other approaches proposed by various scientists to overcome limitations of the standard. Moreover, the latest advances regarding applications of novel extraction techniques and powerful analytical tools that require limited or no sample preparation are critically discussed.
A single‐cell analysis reveals multiple roles of oligodendroglial lineage cells during post‐ischemic regeneration
Authors: Valny Martin , Honsa Pavel , Waloschkova Eliska , Matuskova Hana , Kriska Jan , Kirdajova Denisa , Androvic Peter , Valihrach Lukas , Kubista Mikael , Anderova Miroslava 
Published: February 2018

AbstractNG2 cells represent precursors of oligodendrocytes under physiological conditions; however, following cerebral ischemia they play an important role in glial scar formation. Here, we compared the expression profiles of oligodendroglial lineage cells, after focal cerebral ischemia (FCI) and in Alzheimer's‐like pathology using transgenic mice, which enables genetic fate‐mapping of Cspg4‐positive NG2 cells and their progeny, based on the expression of red fluorescent protein tdTomato. tdTomato‐positive cells possessed the expression profile of NG2 cells and oligodendrocytes; however, based on the expression of cell type‐specific genes, we were able to distinguish between them. To shed light on the changes in the expression patterns caused by FCI, we employed self‐organizing Kohonen maps, enabling the division of NG2 cells and oligodendrocytes into subpopulations based on similarities in the expression profiles of individual cells. We identified three subpopulations of NG2 cells emerging after FCI: proliferative; astrocyte‐like and oligodendrocyte‐like NG2 cells; such phenotypes were further confirmed by immunohistochemistry. Oligodendrocytes themselves formed four subpopulations, which reflected the process of oligodendrocytes maturation. Finally, we used 5‐ethynyl‐2′ deoxyuridine (EdU) labeling to reveal that NG2 cells can differentiate directly into reactive astrocytes without preceding proliferation. In contrast, in Alzheimer's‐like pathology we failed to identify these subpopulations. Collectively, here we identified several yet unknown differences between the expression profiles of NG2 cells and oligodendrocytes, and characterized specific genes contributing to oligodendrocyte maturation and phenotypical changes of NG2 cells after FCI. Moreover, our results suggest that, unlike in Alzheimer's‐like pathology, NG2 cells acquire a multipotent phenotype following FCI.