bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mit Hirn, Herz – und ganz viel Humor
Authors: Schlich Melanie 
Published: November 2018

ZusammenfassungWas ist Humor? Warum lachen wir? Hat überhaupt jeder Mensch Humor? Und wie kann
man Humor als Copingstrategie nutzen? Antworten darauf liefert unser
Interventionskoffer, in dem wir Ihnen das Konzept einer Humorgruppe für
psychiatrische Patienten vorstellen.
Akut – und dann?
Authors: Weisbrod Sabine 
Published: November 2018

ZusammenfassungIm neunten Teil unserer Serie geht es um einen Patienten, der sich in suizidaler
Absicht immer wieder selbst verletzt, pflegerische und therapeutische Angebote
auf der Akutstation jedoch ablehnt. Lesen Sie, wie das Pflegeteam es schafft,
mithilfe der systemischen Fallbesprechung neue Perspektiven zu entwickeln, um
dem Patienten zu helfen. Auch hier möchten wir Sie wieder einladen, sich selbst
in die verschiedenen Rollen hineinzuversetzen. Fallen Ihnen weitere Lösungswege
ein? Dann schreiben Sie uns an psych.pflegeheute@thieme.de.
Early Prognostic Value of High-Sensitivity Troponin T after Coronary Artery Bypass Grafting
Authors: Machado Mauricio Nassau , Rodrigues Fernando Bruetto , Grigolo Ingrid Hellen , Sabbag Amália Tieco Rocha , Silva Osvaldo Lourenço , Maia Lilia Nigro , Nakazone Marcelo Arruda 
Published: November 2018

Abstract
Background Periprocedural myocardial injury after coronary artery bypass grafting (CABG) may affect the patient's prognosis and may be due to a different set of factors beyond the atherosclerotic plaque instability. Considering the challenges in the diagnosis of myocardial injury after CABG, the aim of this study was to determine the association between postoperative early elevation of high-sensitivity troponin T (hsTnT) and all-cause 30-day mortality after CABG.
Methods We enrolled 600 consecutive patients who underwent CABG. The hsTnT value was measured immediately before surgery and in the morning of the first postoperative day.
Results The baseline hsTnT was 13 ng/L (7–26 ng/L) and 273 patients (45.7%) had baseline hsTnT above the 99th percentile/upper reference limit (URL) (14 ng/L). The median for hsTnT at first postoperative day was 235 ng/L (152–425 ng/L). We calculated the postoperative hsTnT ratio to URL for each patient, representing the number of times exceeding the URL (hsTnT value divided by 14 ng/L). The multivariate analysis by Cox proportional hazard model revealed that age (years) (hazard ratio [HR] = 1.13, 95% confidence interval [CI]: 1.07–1.20; p < 0.001) and postoperative hsTnT ratio to URL (per 10-fold increase) (HR = 1.06, 95% CI: 1.04–1.08; p < 0.001) were independent predictors of all-cause 30-day mortality after CABG.
Conclusion In our series, age and higher postoperative hsTnT levels were independent and reliable predictors of all-cause 30-day mortality after CABG.
Sutureless versus Stented Bioprostheses for Aortic Valve Replacement: The Randomized PERSIST-AVR Study Design
Authors: Lorusso Roberto , Folliguet Thierry , Shrestha Malakh , Meuris Bart , Kappetein Arie Pieter , Roselli Eric , Klersy Catherine , Nozza Michele , Verhees Luc , Larracas Cristina , Goisis Giovanni , Fischlein Theodor 
Published: November 2018

Abstract
Introduction Sutureless biological valves for surgical aortic valve replacement (SAVR), characterized by the absence of anchoring sutures at the aortic annulus, are gaining popularity because of ease and reproducibility of implant, shorter operating times, and enhancement of minimally invasive approaches. The stentless configuration of the sutureless valve was designed to achieve optimal hemodynamic performance.
Materials and Methods PERSIST-AVR (PERceval Sutureless Implant versus STandard Aortic Valve Replacement) is a prospective, randomized, adaptive, open-label, international, postmarket trial (NCT02673697). The primary objective of the trial is to assess the safety and efficacy of the Perceval (LivaNova, London, UK) sutureless bioprosthesis among patients undergoing SAVR in the presence of severe aortic stenosis to demonstrate the noninferiority of Perceval as compared with standard sutured stented bioprosthetic aortic valve as an isolated procedure or combined with coronary artery bypass grafting. Sample size will be determined adaptively through interim analyses performed by an Independent Statistical Unit till a maximum of 1,234 patients, enrolled at ∼60 sites in countries where the device is commercially available. Patients will be followed up for 5 years after implant. The primary end point is the number of patients free from major adverse cardiac and cerebrovascular-related events at 1 year. Additional secondary outcomes will be assessed up to 5 years.
Discussion PERSIST-AVR is the first prospective, randomized study comparing in-hospital and postdischarge outcomes in a robust population of patients undergoing SAVR with either the Perceval sutureless bioprosthesis or a conventional sutured stented bioprosthesis up to 5 years.
The acquisition of Spanish passives: The Comparison Between Subject Experiencer Versus Actional Verbs and Direct Aspectual Semantic Evidence for the Adjectival Interpretation
Authors: Oliva Jesús , Wexler Kenneth 
Published: November 2018

We test the maturational/adjectival analysis theory of development of passives in Spanish. Children perform less well on psychological passives than on actional passives. Since Borer and Wexler (1987), the most prominent hypothesis is that this difference is due to children’s use of an adjectival interpretation of passives. Spanish passives are aux + participle, with different auxiliaries for verbal/adjectival. In Experiment 1, children perform better on actional than on psychological passives. Experiment 2, using the method of Gavarró and Parramon (2017), tests the eventive/stative interpretation of passives directly. As predicted, children often recover an incorrect stative interpretation for verbal passives. Strikingly, the non-commonsensical prediction of the theory that there is a negative correlation between adult-like performance in the theta-role and aspect experiments is confirmed.
CCQM-K120 (Carbon dioxide at background and urban level)
Authors: Flores Edgar , Viallon Joële , Choteau Tiphaine , Moussay Philippe , Idrees Faraz , Wielgosz Robert I , Lee Jeongsoon , Zalewska Ewelina , Nieuwenkamp Gerard , Veen Adriaan van der , Konopelko L A , Kustikov Y A , Kolobova A V , Chubchenko Y K , Efremova O V , Zhe BI , Zhou Zeyi , Zhou Zeyi , Rhoderick George C , Hodge Joseph T , Shimosaka Takuya , Aoki Nobuyuki , Hall Brad , Brewer Paul , Cieciora Dariusz , Sega Michela , Macé Tatiana , Fükő Judit , Nagyné Szilágyi Zsófia , Büki Tamás , Jozela Mudalo I , Ntsasa Napo G , Leshabane Nompumelelo , Tshilongo James , Johri Prabha , Tarhan Tanil 
Published: November 2018

CCQM-K120.a comparison involves preparing standards of carbon dioxide in air which are fit for purpose for the atmospheric monitoring community, with stringent requirements on matrix composition and measurement uncertainty of the CO2 mole fraction. This represents an analytical challenge and is therefore considered as a Track C comparison. The comparison will underpin CMC claims for CO2 in air for standards and calibrations services for the atmospheric monitoring community, matrix matched to real air, over the mole fraction range of 250 μmol/mol to 520 μmol/mol.
CCQM-K120.b comparison tests core skills and competencies required in gravimetric preparation, analytical certification and purity analysis. It is considered as a Track A comparison. It will underpin CO2 in air and nitrogen claims in a mole fraction range starting at the smallest participant's reported expanded uncertainty and ending at 500 mmol/mol. Participants successful in this comparison may use their result in the flexible scheme and underpin claims for all core mixtures
This study has involved a comparison at the BIPM of a suite of 44 gas standards prepared by each of the participating laboratories. Fourteen laboratories took part in both comparisons (CCQM-K120.a, CCQM-K120.b) and just one solely in the CCQM-K120.b comparison.
The standards were sent to the BIPM where the comparison measurements were performed. Two measurement methods were used to compare the standards, to ensure no measurement method dependant bias: GC-FID and FTIR spectroscopic analysis corrected for isotopic variation in the CO2 gases, measured at the BIPM using absorption laser spectroscopy. Following the advice of the CCQM Gas Analysis Working Group, results from the FTIR method were used to calculate the key comparison reference values.
KEY WORDS FOR SEARCH
FTIR, CO2, GC-FID, Carbon dioxide at background level, Carbon dioxide at urban level, Delta Ray, CO2 gas standards

Main text

To reach the main text of this paper, click on Final Report. Note that this text is that which appears in Appendix B of the BIPM key comparison database kcdb.bipm.org/.
The final report has been peer-reviewed and approved for publication by the CCQM, according to the provisions of the CIPM Mutual Recognition Arrangement (CIPM MRA).
Validation of electron microscopy initial models via small angle X-ray scattering curves
Authors: Jiménez Amaya , Jonic Slavica , Majtner Tomas , Otón Joaquín , Vilas Jose Luis , Maluenda David , Mota Javier , Ramírez-Aportela Erney , Martínez Marta , Rancel Yaiza , Segura Joan , Sánchez-García Ruben , Melero Roberto , del Cano Laura , Conesa Pablo , Skjaerven Lars , Marabini Roberto , Carazo Jose M , Sorzano Carlos Oscar S 
Published: November 2018

Abstract

Motivation
Cryo electron microscopy (EM) is currently one of the main tools to reveal the structural information of biological macromolecules. The re-construction of three-dimensional (3D) maps is typically carried out following an iterative process that requires an initial estimation of the 3D map to be refined in subsequent steps. Therefore, its determination is key in the quality of the final results, and there are cases in which it is still an open issue in single particle analysis (SPA). Small angle X-ray scattering (SAXS) is a well-known technique applied to structural biology. It is useful from small nanostructures up to macromolecular ensembles for its ability to obtain low resolution information of the biological sample measuring its X-ray scattering curve. These curves, together with further analysis, are able to yield information on the sizes, shapes and structures of the analyzed particles.

Results
In this paper, we show how the low resolution structural information revealed by SAXS is very useful for the validation of EM initial 3D models in SPA, helping the following refinement process to obtain more accurate 3D structures. For this purpose, we approximate the initial map by pseudo-atoms and predict the SAXS curve expected for this pseudo-atomic structure. The match between the predicted and experimental SAXS curves is considered as a good sign of the correctness of the EM initial map.

Availability and implementation
The algorithm is freely available as part of the Scipion 1.2 software at http://scipion.i2pc.es/.
PPaxe: easy extraction of protein occurrence and interactions from the scientific literature
Authors: Castillo-Lara S , Abril J F 
Published: November 2018

Abstract

Motivation
Protein–protein interactions (PPIs) are very important to build models for understanding many biological processes. Although several databases hold many of these interactions, exploring them, selecting those relevant for a given subject and contextualizing them can be a difficult task for researchers. Extracting PPIs directly from the scientific literature can be very helpful for providing such context, as the sentences describing these interactions may give insights to researchers in helpful ways.

Results
We have developed PPaxe, a python module and a web application that allows users to extract PPIs and protein occurrence from a given set of PubMed and PubMedCentral articles. It presents the results of the analysis in different ways to help researchers export, filter and analyze the results easily.

Availability and implementation
PPaxe web demo is freely available at https://compgen.bio.ub.edu/PPaxe. All the software can be downloaded from https://compgen.bio.ub.edu/PPaxe/download, including a command-line version and docker containers for an easy installation.

Supplementary information
Supplementary data are available at Bioinformatics online.
Performance of Stool-testing Recommendations for Acute Gastroenteritis When Used to Identify Children With 9 Potential Bacterial Enteropathogens
Authors: Tarr Gillian A M , Chui Linda , Lee Bonita E , Pang Xiao-Li , Ali Samina , Nettel-Aguirre Alberto , Vanderkooi Otto G , Berenger Byron M , Dickinson James , Tarr Phillip I , Drews Steven , MacDonald Judy , Kim Kelly , Freedman Stephen B 
Published: November 2018

AbstractBackgroundThe ability to identify bacterial pathogens that necessitate specific clinical management or public health action in children with acute gastroenteritis is crucial to patient care and public health. However, existing stool-testing guidelines offer inconsistent recommendations, and their performance characteristics are unknown. We evaluated 6 leading gastroenteritis guidelines (eg, those of the Centers for Disease Control and Prevention and Infectious Disease Society of America) that recommend when to test children’s stool for bacterial enteropathogens.MethodsVia 2 emergency departments in Alberta, Canada, we enrolled 2447 children &lt;18 years old who presented with ≥3 episodes of diarrhea and/or vomiting in a 24-hour period. All participants were tested for 9 bacterial enteropathogens: Aeromonas, Campylobacter, Escherichia coli O157, other Shiga toxin–producing E. coli, enterotoxigenic E. coli, Salmonella, Shigella, Vibrio, and Yersinia. Patient data gathered at the index visit were used to determine whether guidelines would recommend testing. Sensitivity and specificity to recommend testing for children with bacterial enteropathogens were calculated for each guideline.ResultsOutcome data were available for 2391 (97.7%) participants, and 6% (144/2391) of participants tested positive for a bacterial enteropathogen. Guideline sensitivity ranged from 25.8% (95% confidence interval [CI] 18.7–33.0%) to 66.9% (95% CI 59.3–74.6%), and varied for individual pathogens. Guideline specificity for all bacterial enteropathogens ranged from 63.6% (95% CI 61.6–65.6%) to 96.5% (95% CI 95.7–97.2%).ConclusionsNo guideline provided optimally balanced performance. The most sensitive guidelines missed one-third of cases and would drastically increase testing volumes. The most specific guidelines missed almost 75% of cases.
TUBA1A mutations identified in lissencephaly patients dominantly disrupt neuronal migration and impair dynein activity
Authors: Aiken Jayne , Moore Jeffrey K , Bates Emily A 
Published: November 2018

Abstract
The microtubule cytoskeleton supports diverse cellular morphogenesis and migration processes during brain development. Mutations in tubulin genes are associated with severe human brain malformations known as ‘tubulinopathies’; however, it is not understood how molecular-level changes in microtubule subunits lead to brain malformations. In this study, we demonstrate that missense mutations affecting arginine at position 402 (R402) of TUBA1A α-tubulin selectively impair dynein motor activity and severely and dominantly disrupt cortical neuronal migration. TUBA1A is the most commonly affected tubulin gene in tubulinopathy patients, and mutations altering R402 account for 30% of all reported TUBA1A mutations. We show for the first time that ectopic expression of TUBA1A-R402C and TUBA1A-R402H patient alleles is sufficient to dominantly disrupt cortical neuronal migration in the developing mouse brain, strongly supporting a causal role in the pathology of brain malformation. To isolate the precise molecular impact of R402 mutations, we generated analogous R402C and R402H mutations in budding yeast α-tubulin, which exhibit a simplified microtubule cytoskeleton. We find that R402 mutant tubulins assemble into microtubules that support normal kinesin motor activity but fail to support the activity of dynein motors. Importantly, the level of dynein impairment scales with the expression level of the mutant in the cell, suggesting a ‘poisoning’ mechanism in which R402 mutant α-tubulin acts dominantly by populating microtubules with defective binding sites for dynein. Based on our results, we propose a new model for the molecular pathology of tubulinopathies that may also extend to other tubulin-related neuropathies.
Welfare regimes modify the association of disadvantaged adult-life socioeconomic circumstances with self-rated health in old age
Authors: Sieber Stefan , Cheval Boris , Orsholits Dan , Van der Linden Bernadette W , Guessous Idris , Gabriel Rainer , Kliegel Matthias , Aartsen Marja J , Boisgontier Matthieu P , Courvoisier Delphine , Burton-Jeangros Claudine , Cullati Stéphane 
Published: November 2018

Abstract

Background
Welfare regimes in Europe modify individuals’ socioeconomic trajectories over their life-course, and, ultimately, the link between socioeconomic circumstances (SECs) and health. This paper aimed to assess whether the associations between life-course SECs (early-life, young adult-life, middle-age and old-age) and risk of poor self-rated health (SRH) trajectories in old age are modified by welfare regimes (Scandinavian [SC], Bismarckian [BM], Southern European [SE], Eastern European [EE]).

Methods
We used data from the longitudinal SHARE survey. Early-life SECs consisted of four indicators of living conditions at age 10. Young adult-life, middle-age, and old-age SECs indicators were education, main occupation and satisfaction with household income, respectively. The association of life-course SECs with poor SRH trajectories was analysed by confounder-adjusted multilevel logistic regression models stratified by welfare regime. We included 24 011 participants (3626 in SC, 10 256 in BM, 6891 in SE, 3238 in EE) aged 50 to 96 years from 13 European countries.

Results
The risk of poor SRH increased gradually with early-life SECs from most advantaged to most disadvantaged. The addition of adult-life SECs differentially attenuated the association of early-life SECs and SRH at older age across regimes: education attenuated the association only in SC and SE regimes and occupation only in SC and BM regimes; satisfaction with household income attenuated the association across regimes.

Conclusions
Early-life SECs have a long-lasting effect on SRH in all welfare regimes. Adult-life SECs attenuated this influence differently across welfare regimes.
A systematic review of the effects of implementing clinical pathways supported by health information technologies
Authors: Neame Matthew T , Chacko Jerry , Surace Anna E , Sinha Ian P , Hawcutt Daniel B 
Published: November 2018

AbstractObjectiveHealth information technology (HIT) interventions include electronic patient records, prescribing, and ordering systems. Clinical pathways are multidisciplinary plans of care that enable the delivery of evidence-based healthcare. Our objective was to systematically review the effects of implementing HIT-supported clinical pathways.Materials and MethodsA systematic review protocol was developed including Medline, Embase, and CENTRAL database searches. We recorded data relating to study design, participants, intervention, and outcome characteristics and formally assessed risk of bias.ResultsForty-four studies involving more than 270 000 patients were included. Investigation methodologies included before-after (n = 16, 36.4%), noncomparative (n = 14, 31.8%), interrupted time series (n = 5, 11.4%), retrospective cohort (n = 4, 9.1%), cluster randomized (n = 2, 4.5%), controlled before-after (n = 1, 2.3%), prospective case-control (n = 1, 2.3%), and prospective cohort (n = 1, 2.3%) study designs. Clinical decision support (n = 25, 56.8%), modified electronic documentation (n = 23, 52.3%), and computerized provider order entry (n = 23, 52.3%) were the most frequently utilized HIT interventions. The majority of studies (n = 38, 86.4%) reported benefits associated with HIT-supported pathways. These included reported improvements in objectively measured patient outcomes (n = 15, 34.1%), quality of care (n = 29, 65.9%), and healthcare resource utilization (n = 10, n = 22.7%).DiscussionAlthough most studies reported improvements in outcomes, the strength of evidence was limited by the study designs that were utilized.ConclusionsOngoing evaluations of HIT-supported clinical pathways are justified but would benefit from study designs that report key outcomes (including adverse events) and minimize the risk of bias.
Identifying translational science through embeddings of controlled vocabularies
Authors: Ke Qing 
Published: November 2018

Abstract

Objective
Translational science aims at “translating” basic scientific discoveries into clinical applications. The identification of translational science has practicality such as evaluating the effectiveness of investments made into large programs like the Clinical and Translational Science Awards. Despite several proposed methods that group publications—the primary unit of research output—into some categories, we still lack a quantitative way to place articles onto the full, continuous spectrum from basic research to clinical medicine.

Materials and Methods
I learn vector representations of controlled vocabularies assigned to Medline articles to obtain a translational axis that points from basic science to clinical medicine. The projected position of a term on the translational axis, expressed by a continuous quantity, indicates the term’s “appliedness.” The position of an article, determined by the average location over its terms, quantifies the degree of its appliedness, which I term the level score.

Results
I validate the present method by comparing with previous techniques, showing excellent agreement yet uncovering significant variations of scores of articles in previously defined categories. The measure allows us to characterize the standing of journals, disciplines, and the entire biomedical literature along the basic-applied spectrum. Analysis on large-scale citation network reveals 2 main findings. First, direct citations mainly occurred between articles with similar scores. Second, shortest paths are more likely ended up with an article closer to the basic end of the spectrum, regardless of where the starting article is on the spectrum.

Conclusions
The proposed method provides a quantitative way to identify translational science.
The Genomic Landscape of Mucinous Breast Cancer
Authors: Pareja Fresia , Lee Ju Youn , Brown David N , Piscuoglio Salvatore , Gularte-Mérida Rodrigo , Selenica Pier , Da Cruz Paula Arnaud , Arunachalam Sasi , Kumar Rahul , Geyer Felipe C , Silveira Catarina , da Silva Edaise M , Li Anqi , Marchiò Caterina , Ng Charlotte K Y , Mariani Odette , Fuhrmann Laetitia , Wen Hannah Y , Norton Larry , Vincent-Salomon Anne , Brogi Edi , Reis-Filho Jorge S , Weigelt Britta 
Published: November 2018

Abstract
Mucinous carcinoma of the breast (MCB) is a rare histologic form of estrogen receptor (ER)-positive/HER2-negative breast cancer (BC) characterized by tumor cells floating in lakes of mucin. We assessed the genomic landscape of 32 MCBs by whole-exome sequencing and/or RNA-sequencing. GATA3 (23.8%), KMT2C (19.0%), and MAP3K1 (14.3%) were the most frequently mutated genes in pure MCBs. In addition, two recurrent but not pathognomonic fusion genes, OAZ1-CSNK1G2 and RFC4-LPP, were detected in 3/31 (9.7%) and 2/31 (6.5%) samples, respectively. Compared with ER-positive/HER2-negative common forms of BC, MCBs displayed lower PIK3CA and TP53 mutation rates and fewer concurrent 1q gains and 16q losses. Clonal decomposition analysis of the mucinous and ductal components independently microdissected from five mixed MCBs revealed that they are clonally related and evolve following clonal selection or parallel evolution. Our findings indicate that MCB represents a genetically distinct ER-positive/HER2-negative form of BC.