bluuebunny/crossref_metadata_2025_split huggingface dataset:
‘You Decide’: Relationship-Based Knowledge and Parents’ Participation in High-Risk Child Protection Crisis Interventions
Authors: Saar-Heiman Yuval , Krumer-Nevo Michal 
Published: June 2019

AbstractIn the scholarly writing on child protection, there is a broad consensus regarding the importance of parents’ participation in knowledge-production processes. However, there is limited research on the conditions required to make parental participation possible in high-risk crisis situations. In particular, there is a dearth of writing that takes into consideration the context of poverty that influences families’ lives and the power imbalances between social workers and parents that are evident in these processes. Through a case illustration of a high-risk crisis situation in the Israeli child protection system, this article examines the potential contribution of a developing critical paradigm—the Poverty-Aware Paradigm—to the promotion of parents’ participation in high-risk crisis situations. Specifically, it points to ‘relationship-based knowledge’ as an organizing axis for knowledge production, and to its derivative, ‘dialogue on power/knowledge’, as a useful practice in child protection interventions. The case analysis reveals three distinguishing features of this dialogue: (i) the social worker holds a dialectic stance regarding knowledge; (ii) the social worker and the parents negotiate their interpretations; and (iii) the social worker shares common hopes and worries with the parents.
Dynamic functional connectivity changes associated with dementia in Parkinson’s disease
Authors: Fiorenzato Eleonora , Strafella Antonio P , Kim Jinhee , Schifano Roberta , Weis Luca , Antonini Angelo , Biundo Roberta 
Published: June 2019

AbstractDynamic functional connectivity captures temporal variations of functional connectivity during MRI acquisition and it may be a suitable method to detect cognitive changes in Parkinson’s disease. In this study, we evaluated 118 patients with Parkinson’s disease matched for age, sex and education with 35 healthy control subjects. Patients with Parkinson’s disease were classified with normal cognition (n = 52), mild cognitive impairment (n = 46), and dementia (n = 20) based on an extensive neuropsychological evaluation. Resting state functional MRI and a sliding-window approach were used to study the dynamic functional connectivity. Dynamic analysis suggested two distinct connectivity ‘States’ across the entire group: a more frequent, segregated brain state characterized by the predominance of within-network connections, State I, and a less frequent, integrated state with strongly connected functional internetwork components, State II. In Parkinson’s disease, State I occurred 13.89% more often than in healthy control subjects, paralleled by a proportional reduction of State II. Parkinson’s disease subgroups analyses showed the segregated state occurred more frequently in Parkinson’s disease dementia than in mild cognitive impairment and normal cognition groups. Further, patients with Parkinson’s disease dementia dwelled significantly longer in the segregated State I, and showed a significant lower number of transitions to the strongly interconnected State II compared to the other subgroups. Our study indicates that dementia in Parkinson’s disease is characterized by altered temporal properties in dynamic connectivity. In addition, our results show that increased dwell time in the segregated state and reduced number of transitions between states are associated with presence of dementia in Parkinson’s disease. Further studies on dynamic functional connectivity changes could help to better understand the progressive dysfunction of networks between Parkinson’s disease cognitive states.
CDEK: Clinical Drug Experience Knowledgebase
Authors: Griesenauer Rebekah H , Schillebeeckx Constantino , Kinch Michael S 
Published: June 2019

Abstract
The Clinical Drug Experience Knowledgebase (CDEK) is a database and web platform of active pharmaceutical ingredients with evidence of clinical testing as well as the organizations involved in their research and development. CDEK was curated by disambiguating intervention and organization names from ClinicalTrials.gov and cross-referencing these entries with other prominent drug databases. Approximately 43% of active pharmaceutical ingredients in the CDEK database were sourced from ClinicalTrials.gov and cannot be found in any other prominent compound-oriented database. The contents of CDEK are structured around three pillars: active pharmaceutical ingredients (n = 22 292), clinical trials (n = 127 223) and organizations (n = 24 728). The envisioned use of the CDEK is to support the investigation of many aspects of drug development, including discovery, repurposing opportunities, chemo- and bio-informatics, clinical and translational research and regulatory sciences.
Gravitational field calculation in spherical coordinates using variable densities in depth
Authors: Soler Santiago R , Pesce Agustina , Gimenez Mario E , Uieda Leonardo 
Published: June 2019

SUMMARYWe present a new methodology to compute the gravitational fields generated by tesseroids (spherical prisms) whose density varies with depth according to an arbitrary continuous function. It approximates the gravitational fields through the Gauss–Legendre Quadrature along with two discretization algorithms that automatically control its accuracy by adaptively dividing the tesseroid into smaller ones. The first one is a preexisting 2-D adaptive discretization algorithm that reduces the errors due to the distance between the tesseroid and the computation point. The second is a new density-based discretization algorithm that decreases the errors introduced by the variation of the density function with depth. The amount of divisions made by each algorithm is indirectly controlled by two parameters: the distance-size ratio and the delta ratio. We have obtained analytical solutions for a spherical shell with radially variable density and compared them to the results of the numerical model for linear, exponential, and sinusoidal density functions. The heavily oscillating density functions are intended only to test the algorithm to its limits and not to emulate a real world case. These comparisons allowed us to obtain optimal values for the distance-size and delta ratios that yield an accuracy of 0.1 per cent of the analytical solutions. The resulting optimal values of distance-size ratio for the gravitational potential and its gradient are 1 and 2.5, respectively. The density-based discretization algorithm produces no discretizations in the linear density case, but a delta ratio of 0.1 is needed for the exponential and most sinusoidal density functions. These values can be extrapolated to cover most common use cases, which are simpler than oscillating density profiles. However, the distance-size and delta ratios can be configured by the user to increase the accuracy of the results at the expense of computational speed. Finally, we apply this new methodology to model the Neuquén Basin, a foreland basin in Argentina with a maximum depth of over 5000 m, using an exponential density function.
Recent advances in novel therapies for lipid disorders
Authors: Tirronen Annakaisa , Hokkanen Krista , Vuorio Taina , Ylä-Herttuala Seppo 
Published: June 2019

Abstract
The prevalence of lipid disorders is alarmingly increasing in the Western world. They are the result of either primary causes, such as unhealthy lifestyle choices or inherited risk factors, or secondary causes like other diseases or medication. Atypical changes in the synthesis, processing and catabolism of lipoprotein particles may lead to severe hypercholesterolemia, hypertriglyceridemia or elevated Lp(a). Although cholesterol-lowering drugs are the most prescribed medications, not all patients achieve guideline recommended cholesterol levels with the current treatment options, emphasising the need for new therapies. Also, some lipid disorders do not have any treatment options but rely only on stringent dietary restriction. Patients with untreated lipid disorders carry a severe risk of cardiovascular disease, diabetes, non-alcoholic fatty liver disease and pancreatitis among others. To achieve better treatment outcome, novel selective gene expression and epigenetic targeting therapies are constantly being developed. Therapeutic innovations employing targeted RNA technology utilise small interfering RNAs, antisense oligonucleotides, long non-coding RNAs and microRNAs to regulate target protein production whereas viral gene therapy provides functional therapeutic genes and CRISPR/Cas technology relies on gene editing and transcriptional regulation. In this review, we will discuss the latest advances in clinical trials for novel lipid-lowering therapies and potential new targets in pre-clinical phase.
Outcomes of left atrial appendage occlusion using the AtriClip device: a systematic review
Authors: Toale Conor , Fitzmaurice Gerard J , Eaton Donna , Lyne Jonathan , Redmond Karen C 
Published: June 2019

AbstractAtrial fibrillation increases lifetime stroke risk. The left atrial appendage (LAA) is thought to be the source of embolic strokes in up to 90% of cases, and occlusion of the LAA may be safer than the alternative of oral anticoagulation. Occlusion devices, such as the AtriClipTM (AtriCure, Mason, OH, USA) enable safe and reproducible epicardial clipping of the LAA. A systematic review was performed in May 2018, based on the Preferred Reporting Items for Systematic Reviews and Meta-analyses guidelines, using the keyword ‘AtriClip’. A total of 68 papers were identified and reviewed; 11 studies were included. Data including demographics, medical history intervention(s) performed, periprocedural outcomes and follow-up were assessed and analysed. A total of 922 patients were identified. LAA occlusion was achieved in 902 out of 922 patients (97.8%). No device-related adverse events were reported across the studies. The reported incidence of stroke or transient ischaemic attack post-clip placement ranged from 0.2 to 1.5/100 patient-years. Four hundred and seventy-seven of 798 patients (59.7%) had ceased anticoagulation on follow-up. The AtriClip device is safe and effective in the management of patients with atrial fibrillation, either as an adjunct in patients undergoing cardiac surgery or as a stand-alone thoracoscopic procedure.
Are younger cohorts in the USA and England ageing better?
Authors: de la Fuente Javier , Caballero Francisco Félix , Verdes Emese , Rodríguez-Artalejo Fernando , Cabello María , de la Torre-Luque Alejandro , Sánchez-Niubó Albert , María Haro Josep , Ayuso-Mateos José Luis , Chatterji Somnath 
Published: June 2019

Abstract

Background
Whether worldwide increases in life expectancy are accompanied by a better health status is still a debate. People age differently, and there is a need to disentangle whether healthy-ageing pathways can be shaped by cohort effects. This study aims to analyse trends in health status in two large nationally representative samples of older adults from England and the USA.

Methods
The sample comprised 55 684 participants from the first seven waves of the English Longitudinal Study of Ageing (ELSA), and the first 11 waves of the Health and Retirement Study (HRS). A common latent health score based on Bayesian multilevel item response theory was used. Two Bayesian mixed-effects multilevel models were used to assess cohort effects on health in ELSA and HRS separately, controlling for the effect of household wealth and educational attainment.

Results
Similar ageing trends were found in ELSA (β = –0.311; p &lt; 0.001) and HRS (β = –0.393; p &lt; 0.001). The level of education moderated the life-course effect on health in both ELSA (β = –0.082; p &lt; 0.05) and HRS (β = –0.084; p &lt; 0.05). A birth-year effect was found for those belonging to the highest quintiles of household wealth in both ELSA (β = 0.125; p &lt; 0.001) and HRS (β = 0.170; p &lt; 0.001).

Conclusions
Health inequalities have increased in recent cohorts, with the wealthiest participants presenting a better health status in both the USA and English populations. Actions to promote health in the ageing population should consider the increasing inequality scenario, not only by applying highly effective interventions, but also by making them accessible to all members of society.
Local and Nonlocal Singular Liouville Equations in Euclidean Spaces
Authors: Hyder Ali , Mancini Gabriele , Martinazzi Luca 
Published: June 2019

AbstractWe study the metrics of constant $Q$-curvature in the Euclidean space with a prescribed singularity at the origin, namely solutions to the equation $$\begin{equation*} (-\Delta)^{\frac{n}{2}}w=e^{nw}-c\delta_{0} \ \textrm{on}\ {\mathbb{R}}^n, \end{equation*}$$under a finite volume condition. We analyze the asymptotic behavior at infinity and the existence of solutions for every $n\ge 3$ also in a supercritical regime. Finally, we state some open problems.
Compartmentalization of a Multidrug-Resistant Cytomegalovirus UL54 Mutant in a Stem Cell Transplant Recipient with Encephalitis
Authors: Piret Jocelyne , Schibler Manuel , Pham Van Dung , Hantz Sébastien , Giannotti Federica , Masouridi-Levrat Stavroula , Kaiser Laurent , Goyette Nathalie , Alain Sophie , Shi Rong , Boivin Guy 
Published: June 2019

AbstractWe report a case of cytomegalovirus encephalitis in a hematopoietic stem cell transplant recipient. A previously uncharacterized V787E mutation in UL54 was identified in cerebrospinal fluid but not plasma specimens. For the V787E recombinant virus, the half maximal effective concentrations for ganciclovir, foscarnet, and cidofovir were 8.6-, 3.4- and 2.9-fold higher than for wild-type virus, and the replicative capacity was lower. The introduction of a bulkier and negatively charged glutamate residue at position 787 could destabilize the finger domain of UL54 DNA polymerase. Viral genotyping of cerebrospinal fluid is warranted in subjects with cytomegalovirus encephalitis, owing to the low penetration of antivirals in this compartment.
Combination of MexAB-OprM overexpression and mutations in efflux regulators, PBPs and chaperone proteins is responsible for ceftazidime/avibactam resistance in Pseudomonas aeruginosa clinical isolates from US hospitals
Authors: Castanheira Mariana , Doyle Timothy B , Smith Caitlin J , Mendes Rodrigo E , Sader Helio S 
Published: June 2019

AbstractObjectivesTo evaluate ceftazidime/avibactam resistance mechanisms among Pseudomonas aeruginosa clinical isolates and compare with isolates susceptible to this combination.MethodsDuring 2015, 2548 P. aeruginosa isolates were collected in 106 US hospitals and 46 (1.8%) were resistant to ceftazidime/avibactam. These isolates were matched with 109 ceftazidime/avibactam-susceptible isolates resistant to other antipseudomonal agents and were evaluated for the presence of β-lactam resistance mechanisms using WGS analysis and quantitative real-time PCR. Results were analysed using logistic regression comparing the isolate groups to understand the mechanisms of ceftazidime/avibactam resistance.ResultsTwo isolates carried the MBLs blaVIM-1 and blaVIM-2 and another three had unique alterations or deletions in the chromosomal AmpC Ω-loop associated with ceftazidime/avibactam resistance. Overexpression of mexA (+27.4%), disruptions in ampP (+21.7%), mexR (+17.1%) and mexZ (+14.6%) and alterations in ctpA (+13.0%), dnaK (+17.8%) and ftsI (+20.8%) were significantly more prevalent among ceftazidime/avibactam-resistant isolates when compared with their susceptible counterparts independently or in combination. The combination of dnaK alterations and mexA overexpression was more common among ceftazidime/avibactam-resistant by 82×; mexR disruptions and mexA overexpression by 45×; and other two- or three-genotype interactions that included alterations/disruptions in dnaK, ftsI, nalD, mexR, mexZ and mexA overexpression by 6.5× to 34×.ConclusionsResistance to ceftazidime/avibactam among P. aeruginosa clinical isolates has been shown to be a complex interplay of resistance mechanisms that can affect ceftazidime and/or avibactam and some similar findings were reported in laboratory isolates exposed to ceftazidime ± avibactam.
Pedigree-Based Estimation of Reproductive Value
Authors: Hunter Darren C , Pemberton Josephine M , Pilkington Jill G , Morrissey Michael B 
Published: June 2019

AbstractHow successful an individual or cohort is, in terms of their genetic contribution to the future population, is encapsulated in the concept of reproductive value, and is crucial for understanding selection and evolution. Long-term studies of pedigreed populations offer the opportunity to estimate reproductive values directly. However, the degree to which genetic contributions, as defined by a pedigree, may converge on their long-run values within the time frames of available data sets, such that they may be interpreted as estimates of reproductive value, is unclear. We develop a system for pedigree-based calculation of the expected genetic representation that both individuals and cohorts make to the population in the years following their birth. We apply this system to inference of individual and cohort reproductive values in Soay sheep (Ovis aries) from St Kilda, Outer Hebrides. We observe that these genetic contributions appear to become relatively stable within modest time frames. As such, it may be reasonable to consider pedigree-based calculations of genetic contributions to future generations as estimates of reproductive value. This approach and the knowledge that the estimates can stabilize within decades should offer new opportunities to analyze data from pedigreed wild populations, which will be of value to many fields within evolutionary biology and demography.
Local semi-analytic models of magnetic flux transport in protoplanetary discs
Authors: Leung Philip K C , Ogilvie Gordon I 
Published: June 2019

Abstract
The evolution of a large-scale poloidal magnetic field in an accretion disc is an important problem because it determines the launching of winds and the feasibility of the magnetorotational instability to generate turbulence or channel flows. Recent studies, both semi-analytical calculations and numerical simulations, have highlighted the crucial role non-ideal magnetohydrodynamic effects (Ohmic resistivity, Hall drift, and ambipolar diffusion), relevant in the protoplanetary disc context, might play in magnetic flux evolution in the disc. We investigate the flux transport in discs through the use of two 1D semi-analytic models in the vertical direction, exploring regimes where different physical source terms and effects dominate. The governing equations for both models are derived by performing an asymptotic expansion in the limit of a thin disc, with the different regimes isolated through setting the relative order of the leading terms between variables. Flux transport rates and vertical structure profiles are calculated for a range of diffusivities and disc magnetizations. We found that Ohmic and ambipolar diffusivities drive radially outward flux transport with an outwardly inclined field. A wind outflow drives inward flux transport, which is significantly enhanced in the presence of Hall drift in the positive polarity case, $\eta _\mathrm{ H} (\boldsymbol{B}_\mathrm{ z} \cdot \boldsymbol{\Omega }) \gt 0$, an effect which has only been briefly noted before. Coupled only with outward inclination, the Hall effect reduces the flux transport given by a background Ohmic and/or ambipolar diffusivity, but drives no flux transport when it is the only non-ideal effect present.
Monodehydroascorbate Reductase Plays a Role in the Tolerance of Chlamydomonas reinhardtii to Photooxidative Stress
Authors: Yeh Hui-Ling , Lin Tsen-Hung , Chen Chi-Chih , Cheng Tian-Xing , Chang Hsin-Yang , Lee Tse-Min 
Published: June 2019

AbstractMonodehydroascorbate reductase (MDAR; EC 1.6.5.4) is one of the key enzymes in the conversion of oxidized ascorbate (AsA) back to reduced AsA in plants. This study investigated the role of MDAR in the tolerance of Chlamydomonas reinhardtii P.A. Dangeard to photooxidative stress by overexpression and downregulation of the CrMDAR1 gene. For overexpression of CrMDAR1 driven by a HSP70A:RBCS2 fusion promoter, the cells survived under very high-intensity light stress (VHL, 1,800 μmolï¿½m−2ï¿½s−1), while the survival of CC-400 and vector only control (vector without insert) cells decreased for 1.5 h under VHL stress. VHL increased lipid peroxidation of CC-400 but did not alter lipid peroxidation in CrMDAR1 overexpression lines. Additionally, overexpression of CrMDAR1 showed an increase in viability, CrMDAR1 transcript abundance, enzyme activity and the AsA: dehydroascorbate (DHA) ratio. Next, MDAR was downregulated to examine the essential role of MDAR under high light condition (HL, 1,400 μmolï¿½m−2ï¿½s−1). The CrMDAR1 knockdown amiRNA line exhibited a low MDAR transcript abundance and enzyme activity and the survival decreased under HL conditions. Additionally, HL illumination decreased CrMDAR1 transcript abundance, enzyme activity and AsA:DHA ratio of CrMDAR1-downregulation amiRNA lines. Methyl viologen (an O2ï¿½− generator), H2O2 and NaCl treatment could induce an increase in CrMDAR1 transcript level. It represents reactive oxygen species are one of the factor inducing CrMDAR1 gene expression. In conclusion, MDAR plays a role in the tolerance of Chlamydomonas cells to photooxidative stress.
Sleep and timing of death by suicide among U.S. Veterans 2006–2015: analysis of the American Time Use Survey and the National Violent Death Reporting System
Authors: McCarthy Michaela S , Hoffmire Claire , Brenner Lisa A , Nazem Sarra 
Published: June 2019

AbstractStudy ObjectivesSuicide is a top public health priority, and U.S. Veterans are recognized to be at particularly elevated risk. Sleep disturbances are an independent risk factor for suicide; recent empirical data suggest that nocturnal wakefulness may be a key mechanism underlying this association. Given higher rates of sleep disturbances among U.S. Veterans compared with civilians, we examined associations between nocturnal wakefulness and timing of death by suicide in U.S. Veterans and civilians to determine whether temporal suicide patterns differed.MethodsThe American Time Use Survey and the National Violent Death Reporting System were analyzed (2006–2015) to determine whether sleep and temporal suicide patterns differed between age-stratified groups (18–39, 40–64, and ≥65) of U.S. Veterans and civilians. Observed temporal suicide patterns were reported and standardized incidence ratios (SIRs) calculated to compare the percentage of suicides observed with those expected, given the proportion of the population awake, across clock hours.ResultsThe raw proportion of Veteran suicides peaks between the hours of 1000–1200; however, the peak prevalence of suicide after accounting for the population awake is between 0000 and 0300 hr (p < .00001, ϕ = .88). The highest SIR was at midnight; U.S. Veterans were eight times more likely to die by suicide than expected given the population awake (SIR = 8.17; 95% CI = 7.45–8.94).ConclusionsNocturnal wakefulness is associated with increased risk for suicide in U.S. Veterans. Overall patterns of observed suicides by clock hour were similar between U.S. Veterans and civilians. However, Veteran-specific SIRs suggest differences in magnitude of risk by clock hour across age groups. Future research examining female and Post-9/11 U.S. Veterans is warranted.
IV Chaucer
Authors: Twu Krista Sue-Lo , Simon-Jones Lindsey , Pitard Derrick 
Published: June 2019

AbstractThis chapter has six sections: 1. General; 2. The Canterbury Tales; 3. Troilus and Criseyde; 4. The Legend of Good Women; 5. Other Works; 6. Reception. Sections 1(a) and 1(b) are by Lindsey Simon-Jones; section 1(c) is by Krista Sue-Lo Twu; section 2 is by Krista Sue-Lo Twu; sections 3 and 5 are by Derrick Pitard; sections 4 and 6 are by Lindsey Simon-Jones.