bluuebunny/crossref_metadata_2025_split huggingface dataset:
Is the Transplantation of Elderly and DCD Donors in Low MELD Recipients Justified: An Intent-to-treat Analysis
Authors: Malik Tahir H. , Keeney Emma , Jang Anna , Hafeez Muhammad Saad , McDonald Malcolm F. , Goff Cameron , Anand Adrish , Allam Anthony , Mitrani Robert , Cholankeril George , O’Mahony Christine , Cotton Ronald , Galvan Thao N. , Goss John A. , Rana Abbas A. 
Published: November 2024

Background.
Thousands of people die or are removed from the liver transplant waitlist because of deterioration. One major challenge is the donor shortage. Increasing extended criteria donor (ECD) allograft usage can address this. We assessed whether transplanting ECD allografts provides a survival benefit versus remaining on the waitlist for standard allocation.

Methods.
A retrospective analysis of 132 073 liver transplant recipients from 2002 to 2020 via the United National Organ Sharing database was performed. Three survival analyses were performed on model end-stage liver disease (MELD) score inclusive ranges: 8–9, 10–15, and 16–18. Within each analysis, cohorts were divided into “transplanted” or the corresponding “intent-to-treat (ITT)” category. The transplanted cohort was separated into 2 definitions of ECD allografts: donations after circulatory death and donations from donors older than 70 y, along with all-other allografts. Ten-year survival was compared between the 3 transplanted groups and the ITT group.

Results.
When adjusted for covariates, multivariable Cox proportional hazards regression analyses demonstrated that both ECD allografts and all-other allografts had better survival as compared with the ITT cohorts in each of separate analyses for MELD range 10–15 and MELD range 16–18 (P < 0.05).

Conclusions.
In patients with MELD scores as low as 10, there is a survival benefit to using ECD allografts compared with those followed on an ITT basis.
Values, Preferences, and Risk Tolerance of People Waitlisted for a Kidney Transplant Regarding Potential Deceased Donor Organ Profiles: A Systematic Review
Authors: Cutting Rachel B. , Muscat Danielle M. , Patel Pinika , De La Mata Nicole L. , Irish Georgina L. , Wyld Melanie , White Sarah , Webster Angela C. 
Published: November 2024

Background.
Incorporating the views of people waitlisted for a kidney transplant is important when clinicians consider any donor kidney offer.

Methods.
We conducted a systematic review of quantitative and qualitative studies in adult patients on, or under assessment for, the kidney waitlist. We focused on views of extended criteria, increased viral (blood-borne virus), or increased cancer risk in deceased donor kidneys. We systematically searched databases and conference proceedings until April 2024, excluding studies of children, case reports, and commentaries. Studies were appraised using the Johanna Briggs Institute checklists and synthesized using a convergent segregated approach, incorporating narrative and thematic methods.

Results.
We included 25 studies (2630 participants) comprising quantitative surveys, questionnaires, conjoint analysis, and discrete choice experiments (n = 16; 64%) and qualitative semi-structured, in-depth interviews and focus groups (n = 9; 36%). Most studies were from the United States (n = 19; 76%) and focused on extended criteria and increased viral risk donors (n = 24; 96%), with one study considering general risks (4%). None focused on increased cancer-risk donors. We identified 4 themes and 2 subthemes: (1) I want to be free from dialysis, (2) I do not want more health problems, (3) I might not get another chance, (4) I desire shared decision-making but feel powerless to contribute, (4a) I need more information about my health status, prognosis and the transplant process, and (4b) I need more information about donor risk factors.

Conclusions.
Waitlist patients desired information and involvement in decision-making, yet individual prognoses were not fully understood. Integrating shared decision-making from pre- to post-offer will increase knowledge and enhance treatment satisfaction.
Gummatous mitral valve endocarditis from tertiary syphilis
Authors: George Nisha , Pan Daniel , Sze Shirley , Williams Caroline , El-Dean Zein , Zlocha Victor , Webb Elizabeth , Pareek Manish 
Published: November 2024

A 50-year old Romanian gentleman presented with fever, myalgia and 30kg weight loss. He was treated for syphilis previously, after acquiring it from his ex-wife 16 years ago. On examination, there was a pansystolic murmur in the axilla, and the patient had an ataxic gait. Blood tests showed raised inflammatory markers. However, standard investigations for infective endocarditis, including multiple blood cultures, serological titres for fastidious organisms and antibody tests were negative.

CT of the chest, abdomen and pelvis demonstrated hepatosplenomegaly with multiple splenic infarcts. MRI of the head with contrast showed multiple punctate enhancement in the bilateral hemispheres with leptomeningeal enhancement. Transthoracic echocardiogram demonstrated large vegetation leading to severe mitral regurgitation. Serum treponemal antibodies were positive; TPPA was positive at 1:1280 and RPR: 1:4 Treponemal IgM was negative; lumbar puncture syphilis serology was negative. The patient was treated with an extensive period of intravenous antibiotics, in addition to a prosthetic metallic valve replacement, where unusual ragged calcified valvular tissue was observed.

Tertiary syphilis is a difficult diagnosis to confirm, since it can often be indolent and occur in areas of the body where they may go unnoticed. In our case, a diagnosis of syphilitic endocarditis was made from a combination of the history, an initial increase in size of the lesion following antibiotic therapy and observation of likely gumma on the mitral valve during surgery. In such cases, surgery in addition to optimal antimicrobial therapy is necessary for effective treatment.
Reconstructing 3D Spatial Structures of RNA-Tomography Transcriptomes by Tensor Factorization
Authors: Song Tianci , Nguyen Quoc , Kuang Rui 
Published: November 2024

AbstractCells are structurally organized in complex tissues. Mapping the organization of the cells requires reliable 3D molecular profiling. Technologies based on microdissections of tissues provide deep RNA sequencing of orthographically arranged cryosections of a tissue such that the full 3D spatial structure can be reconstructed from deeply sequenced transcriptomes in three views projected like a 3D tomography. In this work, we introduce a method, TFacTomo, to learn a Tensor Factorization for RNA Tomography data from cryosections for constructing 3D spatially resolved gene expressions. TFacTomo combines tensor factorization with a loss function supervised by collapsing the tensor entries to match the gene expressions and tissue mask in each cryosection. To incorporate spatial and functional prior, a regularization by a product graph of the PPI network and spatial graphs is also introduced. In the experiments, TFacTomo is applied to two simulation datasets constructed from a 3D ST mouse brain dataset and a 3D ST human heart dataset, and two RNA Tomography datasets, one from zebrafish embryo and the other from mouse olfactory mucosa. In the simulation, TFacTomo significantly outperforms the benchmark method IPF in the accuracy of predicting the ground-truth gene expressions in the ST datasets based on the projected 1D spatial gene expressions of three orthographic views. In the two RNA Tomography datasets, TFacTomo detects 3D spatial expressions of several marker genes that are consistent with the developmental or functional regions in comparison to staining images. Visual comparisons also suggest that TFacTomo detects more focused regions than the state-of-the-art method.
The assessment of therapeutic autophagy inhibition in NF1 mutated tumor cells
Authors: Zahedi Shadi , Baird-Daniel Eliza , Williams Kyle B. , Williams Rory L. , Morin Andrew , Crespo Michelle , Bratbak Emil , Jones Kendra , Vibhakar Rajeev , Foreman Nicolas K. , Largaespada David A. , Mulcahy Levy Jean 
Published: November 2024

AbstractMAPK pathway activation is found across central nervous system tumors. Neurofibromin 1 (NF1) protein is a GTPase-activating protein and tumor suppressor that negatively regulates RAS protein activity. A NF1 loss of function mutation results in MAPK pathway upregulation and is associated with pediatric gliomas. We previously demonstrated autophagy inhibition improves tumor response to BRAF inhibition. Here we investigate the role of autophagy in NF1 cells in the presence or absence of MEK inhibition (MEKi). NF1 wild type (WT) and NF1 knockout (KO) (HSC1λ, immortalized human Schwann) cells were evaluated. NF1 loss was confirmed, and cell growth was monitored by Incucyte. MAPK/ERK pathway upregulation and autophagy were evaluated via Western blot analysis and RAS pull-down. Effects of MEKi, autophagy inhibition (pharmacologic and genetic), and combination therapy were evaluated via short- and long-term growth assays. NF1 KO cells exhibited MAPK pathway upregulation and increased growth. Additionally, NF KO cells demonstrated increased autophagic activity. Loss of NF1 resulted in increased sensitivity to MEKi and autophagy inhibition alone and in combination. We also demonstrate that the autophagy inhibitor chloroquine (CQ) can improve MEKi sensitivity in a patient harboring a somatic mutation of NF1. This combination is currently being evaluated in clinical trial (NCT04201457).
Light Harvesting Complex II Resists Non-Bilayer Lipid-Induced Polymorphism in Plant Thylakoid Membranes via Lipid Redistribution
Authors: Garg Avinash , Debnath Ananya 
Published: November 2024

AbstractThe plant thylakoid membrane hosting the light-harvesting complex (LHCII) is the site of oxygenic photosynthesis. Contrary to the earlier consensus of a protein-driven single lamellar phase of the thylakoid despite containing 40% non-bilayer-forming lipids, recent experiments confirm the polymorphic state of the functional thylakoid. What, then, is the origin of this polymorphism, and what factors control it? The current Letter addresses the question using a total of 617.8μs long coarse-grained simulations of thylakoids with and without LHCII and varying concentrations of non-bilayer lipids using Martini-2.2 and 3.0 at 323 K. The LHCII redistributes the non-bilayer lipids into its annular region, increases the bending modulus and the stalk formation free energy, reduces the non-zero mean curvature propensity, and resists the polymorphism these lipids promote. The thermodynamic trade-off between non-bilayer lipids and LHCII dictates the degree of nanoscopic curvature leading to the polymorphism crucial for non-photochemical quenching under excess heat conditions.Graphical TOC Entry
The influence of institutional context in the relationship between green management, perceived barriers to sustainability and innovation performance in SMEs
Authors: Rojas-Cabezas Germán , Mora-Esquivel Ronald , Márquez Nicolas , Chacón-Espejo Susana , Nocetti-Núñez Victor , Leiva Juan Carlos 
Published: November 2024

PurposeThis study examines the relationships between green management, perceived barriers to sustainability and innovation performance in Latin American SMEs and how formal and informal institutional factors influence these relationships.Design/methodology/approachThe study used a dataset collected by Iberoamerican small and medium-sized enterprises (SMEs) Observatory in 2022 and included 15 country-specific indicators for Latin American countries published in international data sources to address the formal and informal institutional contexts. Accordingly, the final sample comprises 11,319 SME observations from 16 countries. The analysis involved three phases. First, an R-Type Exploratory Factor Analysis (EFA). Second, a cluster analysis. Third, a testing of the mediation theoretical model between the groups identified in the second study. To this purpose, the analysis included a multigroup analysis for covariance structure by three-stage procedures conducting structural equation modeling (SEM).FindingsThe results revealed that both formal institutions (such as government policies and regulations) and informal institutions (such as social norms and cultural values) have a positive impact of green management practices on innovative outcomes in SMEs. However, the magnitude of this impact varies depending on the level of country-specific performance of the context. Additionally, the perceived barriers to sustainability do not play an intermediary role in this relationship within both institutional contexts. However, the effect of perceived barriers to sustainability on SMEs' innovation performance is diminished in the informal institutional context.Originality/valueThese conclusions provide valuable insights for policymakers seeking to promote sustainable development in Latin America, highlighting the importance of institutional support in fostering SMEs' adoption of ecological practices.
The role of organizational learning capabilities in mediating the impact of workplace happiness on organizational citizenship behavior
Authors: Goel Preeti , Singh Animesh 
Published: November 2024

Purpose
This study explores the role of organizational learning capabilities in mediating the relationship between workplace happiness and organizational citizenship behavior, investigating whether the organization’s ability to foster a learning environment enhances this relationship.

Design/methodology/approach
This study synthesizes the existing research and theoretical framework and explains the mechanism through which organizational learning capabilities plays a mediating role between workplace happiness and organizational citizenship behavior.

Findings
The workplace happiness influences organizational citizenship behavior, and the organizational learning capabilities act as a mediating link between workplace happiness and citizenship behavior, suggesting that a supportive learning culture can amplify the positive effects of workplace happiness on employees’ voluntary, proactive behaviors.

Originality/value
This research emphasizes the importance of developing learning-oriented organizational practices to leverage the benefits of employee happiness, ultimately contributing to enhanced citizenship behavior and organizational effectiveness.
Utilization of technology-enhanced learning tools for sustainable skills acquisition and graduate employability in tertiary institutions in Nigeria
Authors: Ohanu Ifeanyi Benedict , Nwandu Lilian Ogechi , Okadi Ashagwu Ojang , Orji Chibueze Tobias , Ejiofor Toochukwu Eleazar , Chukwuone Chiamaka Adaobi , Ibezim Nnenna Ekpereka , Osinem Emmanuel Chukwugozie 
Published: November 2024

PurposeThe purpose of this study is to explore the key technology-enhanced learning (TEL) tools vocational and technical education (VTE) teachers should learn to promote sustainable skills acquisition and graduate employability, the experiences of VTE teachers about TEL tools and the extent of the relationship between years of teaching experience and the experiences of VTE teachers about TEL tools.Design/methodology/approachThe sample for the study is 318 teachers from 6 tertiary institutions that offer the majority of VTE programs in Nigeria. The instrument for data collection was developed by the researchers and was validated by five experts. The overall reliability index of the instrument is 0.81.FindingsThe study found that in order to use TEL tools, VTE teachers must learn effective instructional delivery and found the experiences of VTE teachers with TEL tools as well as the relationship between teachers' years of experience and experiences of VTE teachers about TEL tools. Also, the study found that access to TEL tools mediates the relationship between VTE teachers' utilization of TEL tools and their performance in utilization of TEL tools.Originality/valueVTE teachers need to learn how to use TEL tools for effective online instructional delivery during and post-emergency situations.
Influence of perceived service quality on word-of-mouth: the mediating role of brand trust and student satisfaction
Authors: Tessema Dagnu Haile , Yesilada Figen , Aghaei Iman , Ahmed Japheth Nuhu 
Published: November 2024

PurposeThe primary purpose of this research is to examine the influence of perceived service quality (PSQ) on word-of-mouth (WOM) directly and through the mediating role of brand trust (BTR) and student satisfaction (SAT) at private universities located in the Turkish Republic of Northern Cyprus (TRNC).Design/methodology/approachA structured questionnaire and convenience sampling were utilized to collect data from 350 students enrolled in selected private universities in the TRNC. Data analysis was conducted using SmartPLS 4.FindingsThis study found that PSQ has a significant influence on WOM. BTR and SAT have a direct and significant effect on WOM. We also found that BTR and SAT mediate the link between PSQ and WOM.Practical implicationsThese findings can serve as a guide for university administration to enhance the quality of services offered to students, as well as to enhance existing policies and procedures.Originality/valueThis paper’s originality lies in the use of cognitive-affective behavioural (CAB) to support the relationship between student perceptions of service quality, brand trust, student satisfaction and WOM.
COVID-19 outbreak and stock price volatility: does ESO have a moderating effect? Evidence from France
Authors: Garfatta Riadh , Zorgati Imen , Talbi Najoua 
Published: November 2024

Purpose
The purpose of this paper is twofold. First, it attempts to examine the impact of covid-19 outbreak on the volatility of stock prices, and then it investigates the moderating role of employee stock ownership on this relationship.

Design/methodology/approach
The study sample includes 108 French companies from the CAC All-Tradable index observed quarterly over a period from the first quarter of 2020 to the fourth quarter of 2022. The GMM estimator of the system in the context of dynamic panel data is used.

Findings
The findings show a positive impact of covid-19 pandemic on stock price volatility. Furthermore, the employee stock ownership has a negative moderating effect on the volatility-Covid-19 relationship. These results suggest that in times of crisis, investors have more confidence in companies with employee stock ownership plans than in those without.

Research limitations/implications
These findings have strong implications for investors and provide guidance for regulators and policymakers. Indeed, companies with greater employee stock ownership (ESO) can better withstand the volatility induced by Covid-19. This highlights the beneficial role of employee involvement in a company’s governance, providing an interesting perspective on risk management and financial stability during times of crisis such as the current pandemic.

Originality/value
The present study is an extension of the existing literature from two perspectives. Firstly, it examines the impact of the covid-19 pandemic on the volatility of stock prices of companies in all sectors, except the financial sector. Secondly, it aims to investigate the moderating effect of ESO on this relationship, which is the major contribution of this work. Indeed, to our knowledge, no study has examined the moderating role of ESO on Covid-volatility relationship, although such a moderating effect is theoretically presumed to exist.
Play alone or play together? A comparative study of single- and multi-person interactions in virtual tourism
Authors: Zhong Lina , Zhu Mengyao , Li Meiling , Morrison Alastair M. , Yang Liyu 
Published: November 2024

Purpose
This paper aims to compare the differences between single- and multi-person interactions in virtual tourism, underpinned by the stimulus-organism-response (S-O-R) framework and media richness theory (MRT).

Design/methodology/approach
In this study, quantitative data gathered from questionnaires applied to 558 individuals was analyzed by using partial least squares structural equation modeling. The moderating role of interaction type was tested through multigroup analysis (MGA).

Findings
The results showed that vividness positively influenced telepresence, perceived attractiveness and authentic experiences; telepresence positively affected authentic experiences and perceived attractiveness; and authentic experiences and perceived attractiveness positively impacted willingness to visit in both interaction groups. A difference was detected between the two groups in that perceptions of media vividness were more easily transformed into a willingness to visit through telepresence in the multi-person interaction group. Interaction type moderated the effect of vividness on telepresence. The vividness of the media had a more significant effect on telepresence among those who participated in virtual tourism together.

Originality/value
In this study, a model was developed to explain how media vividness affected willingness to visit by considering the relationships between telepresence, authentic experiences and perceived attractiveness in virtual reality, as well as the social interaction aspect.
Revolutionizing smart textiles: a comprehensive review of conductive ink printing for sustainable and adaptive wearable applications
Authors: Dutta Sudev , Dogra Sudhanshu , Sharma Sumit 
Published: November 2024

Purpose
The demand of species monitoring for the benefit of various sectors such as industrial, medicinal and ecological has surged rapidly in the recent past. Therefore, the purpose of this paper is to articulate the major developments in synthesizing conductive inks for the structurization of miniaturized as well as disposable or reusable electrochemical equipments.

Design/methodology/approach
This section is not applicable to a review paper.

Findings
Numerous times the need for the use point becomes significant for achieving accurate as well as swift quantification. As an alternate, the wearable and effectual reuseable electrochemical sensors are being practiced. The technique of fabricating devices using conductive inks encompasses novelty, as it provides flexibility in designing the electrodes. The increase in the popularity of inks development is governed by its features of simplicity, reduced cost and waste generation, high production and eco-friendly engineering procedures. Further, the electrochemistry aspects of conductive inks highlighting the importance of their compounds and binders has also been discussed emphasizing on the conductive materials.

Originality/value
This paper is an original review work. This paper will be helpful for manufacturers/researchers from smart wearable textile sector in envisaging innovative developing techniques of sensors as well as biosensors through conductive inks.