bluuebunny/crossref_metadata_2025_split huggingface dataset:
COMPARATIVE EFFECTIVENESS AND SAFETY BETWEEN AMPHOTERICIN B LIPID-FORMULATIONS: A SYSTEMATIC REVIEW
Authors: Grazziotin Luiza Raquel , Moreira Leila Beltrami , Ferreira Maria Angelica Pires 
Published: June 2018

Objectives:It is not yet established the advantages between amphotericin B lipid complex (ABLC) and liposomal (L-AmB) in patients with invasive fungal infections refractory to usual doses of conventional AmB (d-AmB), previous renal impairment, or unacceptable d-AmB renal toxicity. This systematic review aims to compare ABLC and L-AmB effectiveness and safety outcomes in these subgroups of patients.Methods:The search was performed on Medline, Cochrane Library, EMBASE, and LILACS databases. Inclusion criteria: treatment comparing L-AmB with ABLC; patients who had (i) refractory infection after being treated with d-AmB, (ii) previous renal impairment, or (iii) unacceptable d-AmB toxicity. Two investigators independently screened the search results, assessed trial quality, and extracted data. A total of 1,054 articles were identified in the literature. Among those, eleven were selected for full-text reading and five met the inclusion criteria.Results:The five articles included reported on four separate observational studies. Overall, no significant difference was found in clinical relevant outcomes as new-onset dialysis, length of hospital stay, or mortality when comparing both lipid formulations. The studies reported a trend toward lower nephrotoxicity in patients treated with L-AmB. However, the results were imprecise and heterogeneous and the studies presented important methodological biases.Conclusions:The studies included in this systematic review pointed toward less nephrotoxicity events in the L-AmB group. However, due to low quality of evidence and no statistically significant differences in other clinical relevant outcomes, there is no definitive evidence of overall superiority in effectiveness or safety outcomes regarding one lipid formulation or another in this population subgroup.
The Birth of an Imperial Location: Comparative Perspectives on Western Colonialism in China
Authors: NUZZO LUIGI 
Published: June 2018

AbstractThe thematic horizon within which this article takes place is the colonial expansion of the Western powers in China between the nineteenth and the twentieth centuries. Focusing on the foundation of the British, French and American concessions in Tianjin, it aims to reconstruct the Western strategies of colonial governance and the role played by law in the process of production of a new social space. Opened as a treaty port in 1860, Tianjin is the only Chinese city where up to nine foreign concessions coexisted, becoming a complex, hybrid space (in)between East and West, defined by social practices, symbolic representations, and legal categories, which does not coincide simply with the area defined by the entity as a state, nation, or city.
Latent trajectories of alcohol use from early adolescence to young adulthood: Interaction effects between 5-HTTLPR and parenting quality and gender differences
Authors: Su Jinni , Supple Andrew J. , Leerkes Esther M. , Kuo Sally I-Chun 
Published: June 2018

AbstractUsing a large and nationally representative sample, we examined how adolescents’ 5-HTTLPR genotype and perceived parenting quality independently and interactively associated with trajectories of alcohol use from early adolescence to young adulthood and whether/how gender may moderate these associations. The sample for this study included 13,749 adolescents (53.3% female; 56.3% non-Hispanic White, 21.5% Black, 16.0% Hispanic, and 6.1% Asian) followed prospectively from adolescence to young adulthood. Using growth mixture modeling, we identified four distinct trajectories of alcohol use (i.e., persistent heavy alcohol use, developmentally limited alcohol use, late-onset heavy alcohol use, and non/light alcohol use). Results indicated that the short allele of 5-HTTLPR was associated with higher risk of membership in the persistent and the late-onset heavy alcohol use trajectories. Parenting quality was associated with lower likelihoods of following the persistent heavy and the developmentally limited alcohol use trajectories but was not associated with risk of membership for the late-onset heavy drinking trajectory. 5-HTTLPR interacted with parenting quality to predict membership in the persistent heavy alcohol use trajectory for males but not for females. Findings highlighted the importance of considering the heterogeneity in trajectories of alcohol use across development and gender in the study of Gene Environment interactions in alcohol use.
Niche specialization in Bromus tectorum seed bank pathogens
Authors: Meyer Susan E. , Beckstead Julie , Allen Phil S. 
Published: June 2018

AbstractNiche theory predicts that when two species exhibit major niche overlap, one will eventually be eliminated through competitive exclusion. Thus, some degree of niche specialization is required to facilitate coexistence. We examined whether two important seed bank pathogens on the invasive winter annual grass Bromus tectorum (cheatgrass, downy brome) exhibit niche specialization. These pathogens utilize seed resources in complementary ways. Pyrenophora semeniperda is specialized to attack dormant seeds. It penetrates directly through the seed coverings. Hyphae ramify first through the endosperm and then throughout the seed. Seed death results as the embryo is consumed. In contrast, the Fusarium seed rot pathogen (Fusarium sp.) is specialized to attack non-dormant seeds in the early stages of germination. It cannot penetrate seed coverings directly. Instead, it responds to a cue emanating from the radicle end with directional hyphal growth and subsequent penetration at the point of radicle emergence, causing seed death. Non-dormant seeds usually escape P. semeniperda through germination even if infected because it develops more slowly than Fusarium. When water stress slows non-dormant seed germination, both P. semeniperda and Fusarium can attack and cause seed mortality more effectively. The Fusarium seed rot pathogen can sometimes reach epidemic levels and may result in B. tectorum stand failure (‘die-off’). Stands usually re-establish from the persistent seed bank, but if P. semeniperda has also reached high levels and eliminated the seed bank, a die-off can persist indefinitely.
A thermodynamic limit constrains complexity and primitive social function
Authors: Gerrish Philip J , Ferreira Claudia P 
Published: June 2018

AbstractThe evolutionary trend toward increasing complexity and social function is ultimately the result of natural selection's paradoxical tendency to foster cooperation through competition. Cooperating populations ranging from complex societies to somatic tissue are constantly under attack, however, by non-cooperating mutants or transformants, called ‘cheaters’. Structure in these populations promotes the formation of cooperating clusters whose competitive superiority can alone be sufficient to thwart outgrowths of cheaters and thereby maintain cooperation. But we find that when cheaters appear too frequently – exceeding a threshold mutation or transformation rate – their scattered outgrowths infiltrate and break up cooperating clusters, resulting in a cascading loss of social cohesiveness, a switch to net positive selection for cheaters and ultimately in the loss of cooperation. Our findings imply that a critically low mutation rate had to be achieved (perhaps through the advent of proofreading and repair mechanisms) before complex cooperative functions, such as those required for multicellularity and social behaviour, could have evolved and persisted. When mutation rate in our model is also allowed to evolve, the threshold is crossed spontaneously after thousands of generations, at which point cheaters rapidly invade. Probing extrapolations of these findings suggest: (1) in somatic tissue, it is neither social retro-evolution alone nor mutation rate evolution alone but the interplay between these two that ultimately leads to oncogenic transitions; the rate of this coevolution might thereby provide an indicator of lifespan of species, terrestrial or not; (2) the likelihood that extraterrestrial life can be expected to be multicellular and social should be affected by ultraviolet and other mutagenic factors.
Veiled Politics: Experiences with Discrimination among Muslim Americans
Authors: Dana Karam , Lajevardi Nazita , Oskooii Kassra A.R. , Walker Hannah L. 
Published: June 2018

AbstractAnecdotal evidence suggests that Muslim American women who wear the hijab may be particularly vulnerable to the experiences of stigmatization because the hijab represents one of the most obvious and dominant markers of “otherness.” Yet, extant research has surprisingly neglected to systematically examine how such external markers of difference can increase perceptions of discrimination. Drawing from two nationally representative datasets, we examine perceived discrimination among Muslim Americans, and find that veiled women report experiencing both societal and institutional discrimination at much higher rates than their counterparts. In fact, our findings show that the hijab is one of the most important predictors of self-reported discrimination amongallMuslim Americans. Interestingly, however, we also find that men are more likely than women to perceive discrimination once we account for the role of the hijab. Our analysis makes an important contribution to existing research by highlighting the unique experiences of a religious minority group and identifies one important and previously underexplored mechanism by which individuals may be targeted for discrimination—the hijab.
76–81 GHz LTCC antenna for an automotive miniature radar frontend
Authors: Sickinger Frank , Weissbrodt Ernst , Vossiek Martin 
Published: June 2018

AbstractFor a fully 360° detection around a vehicle, novel automotive radar system concepts consist of up to eight radar sensors. The existing sensor-mounting areas, such as front grill or bumper corners would no longer be sufficient. Therefore, additional mounting positions such as B-pillars and side skirts have to be considered, where the radar can observe the side area of the vehicle. However, these new mounting positions usually offer significantly less space, than the established mounting areas. The solution is, to build separate miniature radar frontends that can be placed all over the vehicle and are connected to one central signal processing and power supply unit. Investigations for a miniature radar frontend have been done, based on RF360 low loss non-shrinkage low-temperature cofired ceramic (LTCC) substrate. For the automotive radar band (76–81 GHz), an array antenna has been simulated, manufactured, and the radiation pattern has been measured. A first sensor with a miniature radar frontend based on an LTCC multilayer has been designed and manufactured.
Long‐Term Trends in Tropical (10°N–15°N) Middle Atmosphere (40–110 km) CO2 Cooling
Authors: Ramesh K. , Sridharan S. 
Published: June 2018

AbstractLong‐term trends in middle atmosphere (~40–100 km; here extended up to 110 km), 15 μm carbon dioxide (CO2) cooling rates, and their responses to solar cycle (SC), quasi‐biennial oscillation, and El Niño‐Southern Oscillation are investigated over Indian tropical region (10°N–15°N) using TIMED‐SABER (Thermosphere Ionosphere Mesosphere Energetics and Dynamics‐Sounding of the Atmosphere using Broadband Emission Radiometry) observations during 2002–2015 (23–24 SCs). The CO2 cooling directly depends on temperature so that higher temperature causes more infrared emission from CO2 at 15 μm band and thus provides larger CO2 cooling. The 15 μm CO2 cooling trends are relatively smaller below ~70–80 km, and their amplitude increases above this height. The trends are positive between ~40 and ~62 km peaking at ~47 km (0.06 ± 0.014 K/day/decade) and negative at ~63–74 and ~79–84 km. Further the positive trends increase sharply above ~84 km at the rate of ~0.1–3.0 K/day/decade between 85 and 110 km. The CO2 cooling response to SC, El Niño‐Southern Oscillation, and quasi‐biennial oscillation is smaller below ~70–75 and stronger above this height. The 15 μm CO2 heating exhibits semiannual variation with ~0.1–0.8 K/day during equinoxes between ~70 and 77 km. In addition, the increase in CO2 cooling significantly influences the background temperature and thereby ozone concentration, neutral number density and layer thickness (width) in the stratosphere and mesosphere.
An intriguing relationship between the cyclic diguanylate signaling system and horizontal gene transfer
Authors: Madsen Jonas S , Hylling Ole , Jacquiod Samuel , Pécastaings Sophia , Hansen Lars H , Riber Leise , Vestergaard Gisle , Sørensen Søren J 
Published: June 2018

Abstract
The second messenger cyclic diguanylate (c-di-GMP) is ubiquitously used by bacteria to modulate and shift between different phenotypes including motility, biofilm formation and virulence. Here we show that c-di-GMP-associated genes are widespread on plasmids and that enzymes that synthesize or degrade c-di-GMP are preferentially encoded on transmissible plasmids. Additionally, expression of enzymes that synthesize c-di-GMP was found to increase both biofilm formation and, interestingly, conjugative plasmid transfer rates.
Hedgehog signalling in the tumourigenesis and metastasis of osteosarcoma, and its potential value in the clinical therapy of osteosarcoma
Authors: Yao Zhihong , Han Lei , Chen Yongbin , He Fei , Sun Bin , kamar Santosh , Zhang Ya , Yang Yihao , Wang Cao , Yang Zuozhang 
Published: June 2018

AbstractThe Hedgehog (Hh) signalling pathway is involved in cell differentiation, growth and tissue polarity. This pathway is also involved in the progression and invasion of various human cancers. Osteosarcoma, a subtype of bone cancer, is commonly seen in children and adolescents. Typically, pulmonary osteosarcoma metastases are especially difficult to control. In the present paper, we summarise recent studies on the regulation of osteosarcoma progression and metastasis by downregulating Hh signalling. We also summarise the crosstalk between the Hh pathway and other cancer-related pathways in the tumourigenesis of various cancers. We further summarise and highlight the therapeutic value of potential inhibitors of Hh signalling in the clinical therapy of human cancers.
Glaucocalyxin A exerts anticancer effect on osteosarcoma by inhibiting GLI1 nuclear translocation via regulating PI3K/Akt pathway
Authors: Zhu Jianwei , Sun Yang , Lu Ying , Jiang Xiubo , Ma Bo , Yu Lisha , Zhang Jie , Dong Xiaochen , Zhang Qi 
Published: June 2018

AbstractOsteosarcoma, the most common malignant bone tumor with recurring disease or lung metastases, has become one of the leading causes of death in humans. In the current study, we made an investigation on the anticancer effect of glaucocalyxin A, a bioactive ent-kauranoid diterpenoid isolated from Rabdosia japonica var., and unraveled the underlying mechanisms. Here, we found that Glaucocalyxin A inhibited the cell viability of numerous osteosarcoma cells. Our results showed that Glaucocalyxin A exerted the pro-apoptotic effect on human osteosarcoma cells, MG-63 and HOS cells. Glaucocalyxin A induced apoptosis by mitochondrial apoptotic pathway through several steps including increasing the Bax/Bcl-2 ratio, triggering the intracellular reactive oxygen species (ROS) generation, reducing mitochondrial membrane potential (MMP), and inducing cleavage of caspase-9 and caspase-3. We demonstrated that Glaucocalyxin A induced apoptosis via inhibiting Five-zinc finger Glis 1 (GLI1) activation by overexpression and knockdown of GLI1 in vitro. We also found that Glaucocalyxin A inhibited GLI1 activation via regulating phosphatidylinositol 3 kinase/protein kinase B (PI3K/Akt) signaling pathway. We further confirmed our findings by using PI3K activator and inhibitor to verify the inhibitory effect of Glaucocalyxin A on PI3K/Akt/GLI1 pathway. Moreover, our in vivo study revealed that glaucocalyxin A possessed a remarkable antitumor effect with no toxicity in the xenograft model inoculated with HOS tumor through the same mechanisms as in vitro. In conclusion, our results suggested that Glaucocalyxin A induced apoptosis in osteosarcoma by inhibiting nuclear translocation of GLI1 via regulating PI3K/Akt signaling pathway. Thus, Glaucocalyxin A might be a potential candidate for human osteosarcoma in the future.
Placental exosome-mediated Bta-miR-499-Lin28B/let-7 axis regulates inflammatory bias during early pregnancy
Authors: Zhao Gan , Yang Chao , Yang Jing , Liu Pei , Jiang Kangfeng , Shaukat Aftab , Wu Haichong , Deng Ganzhen 
Published: June 2018

AbstractAbnormal inflammatory bias in the maternal-fetal interface leads to reproductive failure in mammals. Placental exosomes are involved in maternal-fetal communication during pregnancy. However, whether the placenta or fetus is involved in regulating the balance of uterine local inflammation through exosomes remains unclear, and the mechanism must be further explored. Here we demonstrated that placenta-specific exosomes are abundant in the peripheral blood of dairy cows during early pregnancy and selectively load miRNAs, such as bta-miR-499. In vitro, placental exosome-derived bta-miR-499 inhibits the activation of NF-κB via the Lin28B/let-7 axis, thus repressing LPS-induced inflammation in bovine endometrial epithelial (BEND) cells. Subsequently, inhibition of mmu-miR-499 leads to an impaired balance of inflammation at the maternal-fetal interface in vivo, resulting in an increased risk of pregnancy failure due to placental loss and fetal growth restriction. Thus, our data demonstrate that placental exosomal miR-499 may be a critical immune regulator in the regulation of the inflammation balance at the maternal-fetal interface in the early gestation of dairy cows and other mammals.
Increased levels of the long noncoding RNA, HOXA-AS3, promote proliferation of A549 cells
Authors: Zhang Hongyue , Liu Ying , Yan Lixin , Zhang Min , Yu Xiufeng , Du Wei , Wang Siqi , Li Qiaozhi , Chen He , Zhang Yafeng , Sun Hanliang , Tang Zhidong , Zhu Daling 
Published: June 2018

AbstractMany long noncoding RNAs (lncRNAs) have been identified as powerful regulators of lung adenocarcinoma (LAD). However, the role of HOXA-AS3, a novel lncRNA, in LAD is largely unknown. In this study, we showed that HOXA-AS3 was significantly upregulated in LAD tissues and A549 cells. After knockdown of HOXA-AS3, cell proliferation, migration, and invasion were inhibited. Xenografts derived from A549 cells transfected with shRNA/HOXA-AS3 had significantly lower tumor weights and smaller tumor volumes. We also demonstrated that HOXA-AS3 increased HOXA6 mRNA stability by forming an RNA duplex. In addition, HOXA6 promoted cell proliferation, migration, and invasion in vitro. Using a RNA pull-down assay, we found that HOXA-AS3 bonded with NF110, which regulated the cell localization of HOXA-AS3. Moreover, histone acetylation was involved in upregulation of HOXA-AS3. These results demonstrate that HOXA-AS3 was activated in LAD and supported cancer cell progression. Therefore, inhibition of HOXA-AS3 could be an effective targeted therapy for patients with LAD.
Mitochondrial Lon sequesters and stabilizes p53 in the matrix to restrain apoptosis under oxidative stress via its chaperone activity
Authors: Sung Ya-Ju , Kao Ting-Yu , Kuo Cheng-Liang , Fan Chi-Chen , Cheng An Ning , Fang Wei-Cheng , Chou Han-Yu , Lo Yu-Kang , Chen Chung-Hsing , Jiang Shih Sheng , Chang I-Shou , Hsu Chun-Hua , Lee Jin-Ching , Lee Alan Yueh-Luen 
Published: June 2018

AbstractMitochondrial Lon is a multi-function matrix protease with chaperone activity. However, little literature has been undertaken into detailed investigations on how Lon regulates apoptosis through its chaperone activity. Accumulating evidences indicate that various stresses induce transportation of p53 to mitochondria and activate apoptosis in a transcription-independent manner. Here we found that increased Lon interacts with p53 in mitochondrial matrix and restrains the apoptosis induced by p53 under oxidative stress by rescuing the loss of mitochondrial membrane potential (Δψm) and the release of cytochrome C and SMAC/Diablo. Increased chaperone Lon hampers the transcription-dependent apoptotic function of p53 by reducing the mRNA expression of p53 target genes. The ATPase mutant (K529R) of chaperone Lon decreases the interaction with p53 and fails to inhibit apoptosis. Furthermore, the chaperone activity of Lon is important for mitochondrial p53 accumulation in an mtHsp70-dependent manner, which is also important to prevent the cytosolic distribution of p53 from proteasome-dependent degradation. These results indicate that the chaperone activity of Lon is important to bind with mitochondrial p53 by which increased Lon suppresses the apoptotic function of p53 under oxidative stress. Furthermore, mitochondrial Lon-mtHsp70 increases the stability/level of p53 through trafficking and retaining p53 in mitochondrial matrix and preventing the pool of cytosolic p53 from proteasome-dependent degradation in vitro and in clinic.
Inhibition of ANO1/TMEM16A induces apoptosis in human prostate carcinoma cells by activating TNF-α signaling
Authors: Song Yan , Gao Jian , Guan Lizhao , Chen Xiaoling , Gao Jianjun , Wang KeWei 
Published: June 2018

AbstractOverexpression of the Ca2+-activated chloride channel ANO1/TMEM16A is implicated in tumorigenesis, and inhibition of ANO1 overexpression suppresses xenograft tumor growth and invasiveness. However, the underlying molecular mechanism for ANO1 inhibition in suppression of tumorigenesis remains unknown. Here, we show that silencing or inhibition of endogenous ANO1 inhibits cell growth, induces apoptosis and upregulates TNF-α expression in prostate cancer PC-3 cells. Enhancement of TNF-α signaling by ANO1 knockdown leads to upregulation of phosphorylated Fas-associated protein with death domain and caspase activation. Furthermore, silencing of ANO1 inhibits growth of PC-3 xenograft tumors in nude mice and induces apoptosis in tumors via upregulation of TNF-α signaling. Taken together, our findings provide mechanistic insight into promoting apoptosis in prostate cancer cells by ANO1 inhibition through upregulation of TNF-α signaling.