bluuebunny/crossref_metadata_2025_split huggingface dataset:
Treatment of Psoriasis in the Setting of Excessive Alcohol Intake: From the Medical Board of the National Psoriasis Foundation
Authors: Pugliese Douglas J. , Gottlieb Alice B. , Hsu Sylvia , Korman Neil J. , Lebwohl Mark G. , Young Melodie , Bebo Bruce F. , Blauvelt Andrew , Van Voorhees Abby S. ,   for the National Psoriasis Foundation
Published: April 2018

A task force of the National Psoriasis Foundation Medical Board was convened to evaluate treatment options for psoriasis in the setting of excessive alcohol intake. Consensus on treatment algorithms was achieved. Background Psoriasis is a chronic, inflammatory, multisystem disease in which alcohol abuse is higher than in the general population. Alcohol may exacerbate psoriasis and can complicate the choices for therapy given the potential for the combined toxicity of ethanol and treatment. Evidence-based data to guide clinicians in managing these challenging patients are quite limited. Objective Our aim was to create treatment recommendations to help dermatologists manage patients with psoriasis in the setting of excessive alcohol intake. Methods A literature review was conducted to examine treatment options for psoriasis in the setting of excessive alcohol consumption. Results Treatment should be dictated by the severity of disease and any patient comorbidities. First-line choices for extensive disease include phototherapy with narrowband ultraviolet B and photochemotherapy with psoralen plus ultraviolet A, as well as the tumor necrosis factor-alpha inhibitors adalimumab and infliximab. Second-line choices are acitretin, alefacept, cyclosporine, etanercept, and ustekinumab. A third-line choice would be methotrexate. Physicians should be vigilant to check liver function tests regularly. Limitations There are few studies examining treatment options for psoriasis in the setting of excessive alcohol consumption. Thus, these recommendations are based on experience and expert opinions. Conclusion Management of psoriasis in the setting of excessive alcohol consumption requires a thorough understanding of the treatment options that are available. Therapy should be based on the extent of the disease balanced with patients' underlying comorbidities.
Psoriasis Patient–Physician Interactions
Authors: Uhlenhake Elizabeth E. , Feldman Steven R. , Kurkowski David 
Published: April 2018

Background Psoriasis patients are too frequently dissatisfied with the doctor–patient relationship. Purpose To explore how psoriasis patients and dermatologists view the doctor–patient relationship. Methods Separate discussion groups were held in which physicians and patients discussing their thoughts on interactions between psoriasis patients and their physicians. Four groups of six to eight dermatologists discussed patient expectations, observed psoriasis patients as they discussed their views on office visits, and finally discussed the patient encounter after observing the patient dialogues. Results Patients desired more information, quick treatments, clear therapeutic expectations, and recognition of emotional burden. After viewing patient discussions, dermatologists noted that patients often do not receive or internalize adequate information and therefore need further explanation of treatment regimens to increase compliance and patient satisfaction. Conclusions Dermatologists and patients had different impressions of key issues in the psoriasis patient–physician encounter. Patients' needs may be better met by providing more information on psoriasis treatments, even when the information may not change the treatment plan, and by providing information in writing.
Naphthalan Oil in the Treatment of Psoriasis and Psoriatic Arthritis
Authors: Krnjevic-Pezic Gordana , Alajbeg Ivan , Maricić Goran , Pašić Aida , Ćurković Božidar , Ceović Romana , Kostović Krešimir 
Published: April 2018

Background Naphthalan is a specific form of medicinal earth oil, and a number of subtypes are used in topical therapy for psoriasis and psoriatic arthritis. In the present study, yellow naphthalan oil that is enriched with steranes but that has a reduced content of polyaromatics was used. Objective The aim of the study was to assess the effect of naphthalan on psoriatic skin lesions, on painful and swollen joints, and on functional status of patients with psoriatic arthritis. Methods The study included 28 patients with chronic stationary psoriasis (psoriasis vulgaris) and 12 patients with psoriatic arthritis. Results In the psoriasis vulgaris study arm, the mean ± SD Psoriasis Area and Severity Index score was 23.1 ± 7.5 at baseline; it was 7.95 ± 4.08 after 3 weeks of naphthalan treatment. In the majority of patients, naphthalan treatment reduced articular pain and edema and improved mobility of affected joints. Conclusion Naphthalan provides efficacious therapy in the management of mild to moderate psoriasis and psoriatic arthritis.
Biomarkers to Diagnose Early Arthritis in Patients with Psoriasis
Authors: Grace Chiu Ya-Hui , Ritchlin Christopher T. 
Published: April 2018

Background Psoriatic arthritis is a potentially destructive, inflammatory joint disease that affects 20% to 30% of patients with psoriasis. Psoriasis precedes the onset of joint inflammation by approximately 10 years, providing a unique opportunity to intervene and prevent or delay onset of musculoskeletal manifestations. The emergence of sensitive imaging modalities and cellular biomarkers may facilitate early identification of patients with psoriasis who have subclinical joint disease and might help stratify patients with an early onset of arthritis. Methods The translational studies described herein are focused on the development of cellular biomarkers identified with flow cytometry and cell culture techniques in patients with psoriasis and psoriatic arthritis. Results and Conclusion The combination of power Doppler ultrasound imaging and cellular biomarkers (ie, CD16 and dendritic cell specific transmembrane protein) to diagnose early psoriatic arthritis and to stratify patients with established psoriatic arthritis provides a new opportunity to optimize treatment outcomes in this potentially disabling disease.
Survey of Psoriasis Patient Awareness of Metabolic Syndrome Co-Morbidities
Authors: Adelzadeh Lily , Vangala Sitaram , Chiu Melvin W. 
Published: April 2018

Background Psoriasis patients are thought to be at increased risk of having metabolic syndrome. Objective To investigate if psoriasis patients are aware of their condition's association with metabolic syndrome, and whether they have been educated about and screened for metabolic syndrome by their dermatologists. Methods Written surveys distributed to psoriasis patients at a National Psoriasis Foundation fundraising event. Results Of 49 patients who completed the survey, 16 (32.7%), 17 (34.7%), 16 (32.7%), 20 (40.8%), and 16 (32.7%) were aware of the link between psoriasis and diabetes, hypertension, dyslipidemia, obesity, and myocardial infarction, respectively. Only 4.7% to 32.6% of the respondents reported being educated about the link between psoriasis and metabolic syndrome, and 19.6% to 39.1% reported having been screened by their dermatologist for metabolic syndrome components. Limitations Patients may not remember or be aware they are being taught or screened for metabolic syndrome. Conclusion: The majority of psoriasis patients in this survey were unaware of the association of psoriasis with metabolic syndrome and reported infrequent teaching and screening by their dermatologists.
Patient Perspectives on Psoriasis Management: U.S. Results of the Population-Based Multinational Assessment of Psoriasis and Psoriatic Arthritis Survey
Authors: Lebwohl Mark G. , Kavanaugh Arthur , Armstrong April W. , Van Voorhees Abby S. , Kalb Robert E. 
Published: April 2018

Background Psoriasis and psoriatic arthritis are associated with a high disease burden, underdiagnosis, and undertreatment. Objective To further understand unmet needs in patients with psoriasis and psoriatic arthritis. Methods The population-based Multinational Assessment of Psoriasis and Psoriatic Arthritis (MAPP) survey included psoriasis and/or psoriatic arthritis patients selected by list-assisted random digit dialing. We report results from the United States. Results 52,926 households in the United States were screened; 1,005 adults completed the survey. Of these, 73.1% of patients reported a psoriasis diagnosis alone and 26.9% reported psoriatic arthritis (with/without a separate psoriasis diagnosis). Approximately 22% of patients reported no current treatment; <10% of psoriasis and 50% of psoriatic arthritis patients were receiving systemic therapy. Perceived treatment burden, safety and tolerability concerns, and lack of effectiveness were commonly reported as reasons for treatment dissatisfaction and discontinuation. Conclusions Psoriasis and psoriatic arthritis remain undertreated in the United States, marked by high treatment dissatisfaction and discontinuation.
Safety and Efficacy of Combining Biologic with Nonbiologic Therapies for Moderate to Severe Psoriasis: A Review
Authors: Patel Viraat , Levin Ethan , Sorenson Eric , Malakouti Mona , Koo John Y.M. 
Published: April 2018

Background Some psoriasis patients respond inadequately to monotherapy and require combination therapy. Combining a biologic and nonbiologic agent may provide improvement. Objective To review the efficacy and safety of combination treatment with biologic and nonbiologic agents in the treatment of moderate to severe plaque psoriasis. Methods We searched Pubmed for English-language publications evaluating combination treatment with biologic and nonbiologic therapies through June 2014. Results Etancercept was the most commonly used biologic followed by ustekinumab, adalimumab, and infliximab. The majority of nonbiologic therapies reported were narrowband UVB (NBUVB) and methotrexate. Most cases reported increased efficacy with combination therapy with serious adverse events occurring in less than 3% of patients. Conclusion Combination biologic plus nonbiologic therapy, especially NBUVB with biologics is a viable clinical strategy in the treatment of psoriasis patients unresponsive to monotherapy, despite limitations in the data available. However, the long-term impact of these combinations has yet to be determined.
How I treat T-cell chronic active Epstein-Barr virus disease
Authors: Bollard Catherine M. , Cohen Jeffrey I. 
Published: April 2018

Abstract
T-cell chronic active Epstein-Barr virus (CAEBV) is a rare disease in which EBV is present predominantly in T cells that infiltrate the tissues; patients have high levels of EBV in the blood. If untreated, patients often develop liver failure, hemophagocytic lymphohistiocytosis, coronary artery aneurysms, EBV infiltrating T cells impairing organ function, or T-cell lymphomas refractory to treatment. At present, hematopoietic stem-cell transplantation is the only curative therapy, and it is critical to make a proper diagnosis and initiate transplantation before the disease progresses to an irreversible stage. Specific medications such as high-dose systemic corticosteroids or ganciclovir combined with either histone deacetylase inhibitors or bortezomib may temporarily reduce systemic toxicity associated with T-cell CAEBV and allow the patient time to receive a transplant. Relapses of the disease after transplantation have also occurred, and the use of donor-derived virus-specific T cells may help to treat these relapses.
Randomized phase 2 trial of monthly vitamin D to prevent respiratory complications in children with sickle cell disease
Authors: Lee Margaret T. , Kattan Meyer , Fennoy Ilene , Arpadi Stephen M. , Miller Rachel L. , Cremers Serge , McMahon Donald J. , Nieves Jeri W. , Brittenham Gary M. 
Published: April 2018

Key PointsAnnual rates of respiratory illness in sickle cell disease decreased by >50% during the second year of monthly doses of oral vitamin D3. Reduction in rates was similar with high-dose (100 000 IU/mo) and standard-dose (12 000 IU/mo) treatment.
Ασύμμετρη ισχύς, ευρωπαϊκή ολοκλήρωση και εθνική κυριαρχία: Η περίπτωση της ευρωζώνης
Authors: Μαρής Γεώργιος 
Published: April 2018

Κύριος σκοπός αυτής της μελέτης είναι να προσφέρει μια διαφορετική ερμηνεία της διαδικασίας της ευρωπαϊκής ολοκλήρωσης, με την παράθεση ενός εναλλακτικού προτύπου συστηματικής εξέτασης του φαινομένου στο οποίο τονίζεται η σημασία της ασυμμετρίας ως προσδιοριστικού της παράγοντα. Εξετάζεται κυρίως πως η ανάπτυξη ασύμμετρων δυναμικών σχέσεων ανάμεσα στους κύριους δρώντες επηρεάζει τη διαδικασία της ευρωπαϊκής ολοκλήρωσης. Στο ιδιότυπο σύστημα της Ευρωπαϊκής Ένωσης η ασυμμετρία αποκτά τελείως διαφορετικά χαρακτηριστικά σε σχέση με την ασυμμετρία που παρατηρείται στο διεθνές πλαίσιο, συνθήκη η οποία αλλάζει τη φύση της ενοποιητικής διαδικασίας και του προτύπου διακυβέρνησης. Η σημασία της ασυμμετρίας γίνεται εντονότερη στην τρέχουσα περίοδο στην οποία η διαχείριση των ποικίλων κρίσεων και προκλήσεων που αντιμετωπίζει η ΕΕ αποτελεί πεδίο έντονου προβληματισμού και αντιπαράθεσης.
Hospital Readmissions in Patients with Cirrhosis: A Systematic Review
Authors: Orman Eric S. , Ghabril Marwan , Emmett Thomas W. , Chalasani Naga 
Published: April 2018

BACKGROUNDHospital readmission is a significant problem for patients with complex chronic illnesses such as liver cirrhosis.PURPOSEWe aimed to describe the range of readmission risk in patients with cirrhosis and the impact of the model for end‐stage liver disease (MELD) score.DATA SOURCESWe conducted a systematic review of studies identified in Ovid MEDLINE, PubMed, EMBASE, CINAHL, the Cochrane Library, Scopus, Google Scholar, and ClinicalTrials.gov from 2000 to May 2017.STUDY SELECTIONWe examined studies that reported early readmissions (up to 90 days) in patients with cirrhosis. Studies were excluded if they did not examine the association between readmission and at least 1 variable or intervention.DATA EXTRACTIONTwo reviewers independently extracted data on study design, setting, population, interventions, comparisons, and detailed information on readmissions.DATA SYNTHESISOf the 1363 records reviewed, 26 studies met the inclusion and exclusion criteria. Of these studies, 21 were retrospective, and there was significant variation in the inclusion and exclusion criteria. The pooled estimate of 30‐day readmissions was 26%(95% confidence interval [CI], 22%‐30%). Few studies examined readmission preventability or the relationship between readmissions and social determinants of health. Reasons for readmission were highly variable. An increased MELD score was associated with readmissions in most studies. Readmission was associated with increased mortality.CONCLUSIONHospital readmissions frequently occur in patients with cirrhosis and are associated with liver disease severity. The impact of functional and social factors on readmissions is unclear.
Conocimiento experto y autorregulación en adultos mayores jubilados profesionales y no profesionales
Authors: Krzemien Deisy , Richard´s María M , Biscarra María Ayelén 
Published: April 2018

Si bien se han investigado variables psicosociales implicadas en la adaptación posjubilatoria, existe escaso interés en el factor del conocimiento experto. Este estudio propone comparar las metas de vida a partir del retiro jubilatorio en adultos mayores profesionales y no profesionales, y analizar la relación entre el conocimiento experto y las estrategias de autorregulación, con el fin de contrastar empíricamente el modelo del Grupo de Berlín. Se utilizó un diseño correlacional transversal en una muestra de 258 jubilados distribuidos en dos grupos: profesionales y no profesionales. Se hallaron diferencias en la selección de metas entre ambos grupos y se evidenció que el conocimiento experto se relacionó con un mayor uso de estrategias de optimización y compensación. El grupo no profesional utilizó la estrategia compensación en mayor medida, y el grupo profesional presentó un desempeño significativamente mayor en conocimiento experto. Los datos obtenidos sirven al diseño de programas de asistencia prejubilatoria.
Learning from Online Social Ties
Authors: Zhang Yuchi , Godes David 
Published: April 2018

We ask whether online opinions impact consumers’ decision quality and assess whether this impact occurs immediately or requires one to undergo learning first. We focus on a setting where consumers have multiple learning experiences using opinions from both uni- and bidirectional network ties. This allows us to investigate the impact of learning from both weak and strong ties. We find that, with sufficient experience, having more ties may lead to better decisions. However, the dynamic effects are dependent on the strength of the tie. Additional strong ties (operationalized as bidirectional links) lead to immediate positive effects on decision quality. However, additional weak ties (unidirectional, follower relationships) initially lead to lower decision quality. We find beneficial learning effects, however: adding more weak ties improves decision quality once one has sufficient experience in the community. Indeed, more-experienced consumers receive, ultimately, higher positive effects on decision quality from weak ties compared with strong ties. We interpret this as demonstrating that one needs to learn the norms of a new community before using the available information to improve decisions.Data and the online appendix are available at https://doi.org/10.1287/mksc.2017.1076 .
FLP-18 Functions through the G-Protein-Coupled Receptors NPR-1 and NPR-4 to Modulate Reversal Length inCaenorhabditis elegans
Authors: Bhardwaj Ashwani , Thapliyal Saurabh , Dahiya Yogesh , Babu Kavita 
Published: April 2018

Animal behavior is critically dependent on the activity of neuropeptides. Reversals, one of the most conspicuous behaviors inCaenorhabditis elegans, plays an important role in determining the navigation strategy of the animal. Our experiments on hermaphroditeC. elegansshow the involvement of a neuropeptide FLP-18 in modulating reversal length in these hermaphrodites. We show that FLP-18 controls the reversal length by regulating the activity of AVA interneurons through the G-protein-coupled neuropeptide receptors, NPR-4 and NPR-1. We go on to show that the site of action of these receptors is the AVA interneuron for NPR-4 and the ASE sensory neurons for NPR-1. We further show that mutants in the neuropeptide,flp-18, and its receptors show increased reversal lengths. Consistent with the behavioral data, calcium levels in the AVA neuron of freely reversingC. eleganswere significantly higher and persisted for longer durations inflp-18,npr-1,npr-4, andnpr-1 npr-4genetic backgrounds compared with wild-type control animals. Finally, we show that increasing FLP-18 levels through genetic and physiological manipulations causes shorter reversal lengths. Together, our analysis suggests that the FLP-18/NPR-1/NPR-4 signaling is a pivotal point in the regulation of reversal length under varied genetic and environmental conditions.SIGNIFICANCE STATEMENTIn this study, we elucidate the circuit and molecular machinery required for normal reversal behavior in hermaphroditeCaenorhabditis elegans. We delineate the circuit and the neuropeptide receptors required for maintaining reversal length inC. elegans. Our work sheds light on the importance of a single neuropeptide, FLP-18, and how change in levels in this one peptide could allow the animal to change the length of its reversal, thereby modulating how theC. elegansexplores its environment. We also go on to show that FLP-18 functions to maintain reversal length through the neuropeptide receptors NPR-4 and NPR-1. Our study will allow for a better understanding of the complete repertoire of behaviors shown by freely moving animals as they explore their environment.
A comparative, population-based analysis of pituitary incidentalomas vs clinically manifesting sellar masses
Authors: Vaninetti Nadine M , Clarke David B , Zwicker Deborah A , Yip Churn-Ern , Tugwell Barna , Doucette Steve , Theriault Chris , Aldahmani Khaled , Imran Syed Ali 
Published: April 2018

Purpose
Sellar masses may present either with clinical manifestations of mass effect/hormonal dysfunction (CMSM) or incidentally on imaging (pituitary incidentaloma (PI)). This novel population-based study compares these two entities.

Methods
Retrospective analysis of all patients within a provincial pituitary registry between January 2006 and June 2014.

Results
Nine hundred and three patients were included (681 CMSM, 222 PI). CMSM mainly presented with secondary hormone deficiencies (SHDs) or stalk compression (29.7%), whereas PIs were found in association with neurological complaints (34.2%) (P < 0.0001). PIs were more likely to be macroadenomas (70.7 vs 49.9%; P < 0.0001). The commonest pathologies among CMSM were prolactinomas (39.8%) and non-functioning adenomas (NFAs) (50%) in PI (P < 0.0001). SHDs were present in 41.3% CMSM and 31.1% PI patients (P < 0.0001) and visual field deficit in 24.2 and 29.3%, respectively (P = 0.16). CMSM were more likely to require surgery (62.9%) than PI (35.8%) (P < 0.0005). The commonest surgical indications were impaired vision and radiological evidence of optic nerve compression. Over a follow-up period of 5.7 years for CMSM and 5.0 years for PI, tumour growth/recurrence occurred in 7.8% of surgically treated CMSM and 2.6% without surgery and PI, 0 and 4.9%, respectively (P = 1.0). There were no significant differences in the risk of new-onset SHD in CMSM vs PI in those who underwent surgery (P = 0.7) and those who were followed without surgery (P = 0.58).

Conclusions
This novel study compares the long-term trends of PI with CMSM, highlighting the need for comprehensive baseline and long-term radiological and hormonal evaluations in both entities.
Cross-cultural Differences Experienced during Hajj: A Case Study of Acehnese Hajj
Authors: Bustamam-Ahmad Kamaruzzaman , Zakaria Rahmi 
Published: April 2018

The cross-cultural differences experienced by pilgrims during the world’s largest religious ritual, ḥajj, have yet to be explored. It is worthwhile to investigate this issue from an Indonesian perspective. This study uses a phenomenological approach to examine cross-cultural differences experienced by Acehnese pilgrims during ḥajj. The perceptions of Acehnese who have never been to Mecca (‘villagers’) and Acehnese who stayed in Saudi Arabia and its neighbouring countries (‘stayers’) were also probed. The findings show that the pilgrims experienced cross-cultural differences in verbal communication, body movement, physical appearance and dress, the use of space, time, touch, voice, and smell. Cross-culturally, the pilgrims have a different perspective to villagers and stayers. The pilgrims expressed culture shock, while the villagers’ perceptions were primarily shaped by imagined and unverified stories, and the stayers understood their pilgrimage through their long experiences of residing in Arab countries.DOI: 10.15408/sdi.v25i1.5356