bluuebunny/crossref_metadata_2025_split huggingface dataset:
Traditional Chinese medicine understanding of ulcerative colitis
Authors: Huang Teng , Chen Junlu , Zhang Lina , Hao Bin 
Published: February 2019

In recent years，the incidence of ulcerative colitis has been increasing both at home and abroad，therefore，more and more attention has been paid to its recognition and treatment. The pathogenesis of the disease is still unclear in modern medicine，we can discuss from the Chinese medical and hope to better understand ulcerative colitis.
Keywords: Ulcerative colitis; traditiona Chinese medical; Discuss
Tuberculosis’ Total Health care system and patient side diagnosis and Treatment Delay and Associated Factors Among Pulmonary Tuberculosis Patients At Hadiya Zone Public Health Facilities, Southern Ethiopia.
Authors: Getahun Gedeyon , Beyene Tilahun , Abebe Lakew 
Published: February 2019

Background: Delay in TB treatment is significant to both disease prognoses at the individual level and within the community. Even though studies conducted in TB treatment delay there is result inconsistencies due to differences in culture, environment and infrastructure.
Objective: the aim of the study is to assess the tuberculosis treatment Delay and associated factor among pulmonary tuberculosis patients.
Method: Facility based cross sectional study triangulated by Qualitative study was employed on 340 PTB patients in Hadiya zone public health facilities. Three woredas and health facilities were selected by Simple random sampling method. DOTS user at the beginning of data collection was consecutively recruited in to the study until the intended sample size was fulfilled. Multivariable binary Logistic regression was used. A P-value < 0.05 at 95 % CI was considered statistical significance between dependent and predictors variables.
Result: Among 340 PTB patients enrolled in the study, of which 49.1% experienced patient delay, 30% health system delay and 49.8% total delay. Unable to read and write, Poor knowledge of TB (AOR 3.96, 95% CI (2.28 6.86), self-treatment (AOR: 2, 95% CI (1.14, 3.93), financial constraint (AOR: 2.092, 95% CI (1.11, 3.945) , Visiting two or more health care providers (AOR: 3.40, 95% CI (1.910 – 6.07), prolonged referral (AOR: 3.004, 95% CI (1.59, 5.67) were independent predictors of delay.
Conclusion: Nearly half of the total delay was contributed by patient delay. Unable to read and write, Poor knowledge of TB, self-treatment, financial constraints, prolonged referral, several visit of health care provider of two or more and ever used other drugs rather than Anti-TB drugs were found to have association with patient delay and health system delay.
Keywords: Tuberculosis treatment delay, PTB, patient delay and health system delay, Hadiya zone, Ethiopia.
Formulation development of methylprednisolone dispersible tablets using quality by design approach
Authors: Nandhini J , Rajalakshmi AN 
Published: February 2019

The objective of this study was to enhance the solubility of Methylprednisolone by choosing micronized form of drug and to enhance patient compliance by formulating it as dispersible tablets using quality by design (QbD) approach. Dispersible tablets of Methylprednisolone were developed by 23 factorial design. In this study independent variables were concentrations of MCC 102, CCS and Magnesium stearate and dependent variables were disintegration time, hardness and dissolution. The resulting data was fitted into Design Expert Software (Trial Version) and analyzed statistically using analysis of variance (ANOVA). The response surface plots were generated to determine the influence of concentration of MCC 102, CCS and magnesium stearate on responses. The tablets were prepared by direct compression method by choosing micronized form of drug and formulations were evaluated for the standard of dispersible tablets. Results showed that no significant drug-polymer interactions in FTIR studies. According to QbD suggestion the formulation O1 (Desirability- 0.73) with MCC-38mg, CCS-3.5mg and magnesium stearate-2.5mg was formulated and evaluated. The disintegration time was found to be 69 seconds, hardness was found to be 64N and in vitro dissolution with in 30minutes. Optimized O1 formulation was within the limits of standards of dispersible tablets with increased water solubility and better patient compliance. Stability study on optimized O1 formulation showed that there is no significant changes during study period. Thus, O1 formulation was found to be stable. The study indicates that formulation of Methylprednisolone dispersible tablets by using QbD approach is a promising formulation development method.
Keywords: Dispersible tablets, Methylprednisolone, Direct compression, Quality by Design and ANOVA.
Peptide-based Drug Delivery for Curing Cancer
Authors: Huang Wenzhe 
Published: February 2019

Peptides have numerous advantages as the chains help treat cancer, tumor and several complex diseases. The review details on the different structures of peptides that can ensure actual and efficient delivery of therapy to tumor and cancer cases. The co-delivery system mainly aims to improve the therapeutic delivery process regarding manufacturing, targeting, and impact.
Keywords: Nanotechnology, Peptide-based Drug Delivery, cancer
Polyherbal Formulation Concept for Synergic Action: A Review
Authors: Karole Sarita , Shrivastava Sarika , Thomas Shefali , Soni Bhawana , Khan Shifa , Dubey Julekha , Dubey Shashi P. , Khan Nushrat , Jain Deepak Kumar 
Published: February 2019

Formulations restrain 2 or more than 2 herbs are called polyherbal formulation. Drug formulation in Ayurveda is based on 2 principles: Use as a single drug and use of more than one drug. The last is known as polyherbal formulation. The idea of polyherbalism is peculiar to Ayurveda even though it is tricky to explain in term of modern parameters. The Ayurvedic literature Sarangdhar Samhita tinted the idea of polyherbalism to attain greater therapeutic efficacy. Polyherbal formulation has been used all around the earth due to its medicinal and therapeutic application. It has also recognized as polyherbal therapy or herb-herb combination. The active phytochemical constituents of individual plants are inadequate to attain the desirable therapeutic effects. When polyherbal and herbo-mineral formulations combining the multiple herbs in a meticulous ratio, it will give an enhanced therapeutic effect and decrease the toxicity. The active constituents used from individual plant are inadequate to provide attractive pharmacological action. There are evidences that crude plant extracts often have greater potency rather than isolated constituents. In traditional medicine whole plants or mixtures of plants are used rather than isolated compounds. Due to synergism, polyherbalism confers some benefits which are not accessible in single herbal formulations. Polyherbal formulations express high effectiveness in numerous diseases with safe high dose. Based on the nature of the interaction, there are 2 mechanisms on how synergism acts (i.e., pharmacodynamics and pharmacokinetic). In words of pharmacokinetic synergism, the capacity of herb to ease the absorption, distribution, metabolism and elimination of the other herbs is focused. Pharmacodynamics synergism on the other hand, studies the synergistic effect when active constituents with similar therapeutic activity are targeted by diverse mechanism of action. The present review encompasses all the significant features of polyherbal formulation.
Keywords: Polyherbal formulation, Ayurveda, Active constituents, Pharmacodynamics, pharmacokinetic
Extraction and wound healing potential of Nerium Indicum M, Artocarpus Heterophyllus Lam, Murraya Koenigii L, Punica Granatum L on albino rats using burn wound model
Authors: Shukla Renuka , Kashaw Varsha 
Published: February 2019

Objective: The objective of present work was to extract the active constituents and evaluate the wound healing potential of Nerium indicum, Artocarpus heterophyllus, Murraya koenigii, Punica granatum on albino rats using burn wound model. Poly-herbal ointment and gel formulation was developed and compare with the extract of all plants. These plants has shown anti-asthmatic, anti-diabetic, anti-inflammatory, anti-microbial, anti-leukemic, anti-mycobacterial, antibacterial, antioxidant, antiulcer, antiviral, anticancer, antimalarial, anti-inflammatory and wound healing properties. Materials and Methods: Solvent extraction method has been utilized for the separation of the active constituents of interest by using 70% ethanol as a solvent. Poly-herbal ointment and gel formulations has been prepared by mixing the extract of Nerium Indicum, Artocarpus heterophyllus, Murraya koenigii and Punica granatum in different ratio with the ointment base (10-15%) contains PEG and for gel formulation Carbapol-940 base (10-15%). Burn wound model of albino rats has been utilized for the assessment of wound healing potential of the plant extract as well as developed formulations. Results and Conclusion: The studies on burn wound healing model reveals that F2 poly-herbal ointment formulation show better burn wound healing potential in comparison to all other formulations, F-1 ointment formulation as well as extracts of all plants. There was no mortality observed in the tenure of study. Discussion: These data has indicated that ointment and gel poly-herbal formulation of Nerium Indicum, Artocarpus Heterophyllus, Murraya Koenigii and Punica Granatum has been utilized for wound healing purpose and it is safer for topical application. No toxicity and mortality has been observed during the experimental tenure.
Keywords: Wound healing, Nerium indicum, Murraya koenigii, Punica granatum, Artocarpus heterophyllus, burn wound model.
Knowledge regarding Hepatitis B among staff nurses
Authors: Augustine Anitta , George Anumol , Aswathy T.P. , Nithyashree B. V , Rodrigues Devina E 
Published: February 2019

Hospital is a place to get cured from the suffering. Among the members of health team the nurses spend most of their time at the bed side and they are usually considered as angels at the mission of comforting patients. Hepatitis B is a potentially life-threatening viral infection caused by Hepatitis B virus. It can create both acute and chronic diseases and, deemed as a major and serious health problem in the developing countries like India. Materials and methods: The descriptive survey approach adopted in the study aimed to assess the knowledge regarding Hepatitis B infection and its prevention among staff nurses. Self administered structured knowledge questionnaire was developed on the basis of objectives of the study by reviewing the literature of relevant topics and discussion with experts. Result: The data obtained from 100 staff nurses indicated that majority of the subjects (61%) were in the age group of 21-28 years, 84% were females and 16 % males. More than half of the subjects (55%) were with B. Sc qualification 63% were having 1-5 year experience and 62% of subjects were having monthly income between Rs 10,001-20,000. Only 36% of the subjects acquired information from college/friends. Distribution of staff nurses according to their knowledge showed that 86% had adequate knowledge, 12% had moderate knowledge, and 2%had poor knowledge. Conclusion: Nurses have major role in preventive aspect than in curative aspects Nurse through the scientific knowledge and skills are able to collect the data from public. The study results will help the investigators as well as the public to update their knowledge by organizing education programme.
Keywords: Hepatitis B, Prevention, Staff nurses.
Quality by Design: A new practice for production of pharmaceutical products
Authors: Malik Anuj , Gochhayat Gourab , Alam Md Shamshir , Kumar Manish , Pal Preeti , Singh Raj , Saini Vipin 
Published: February 2019

This is the advanced approach for development of pharmaceutical product with full range and specified limits of variables during procurements, storage and manufacturing process with a qualification, at desired level of quality within the limits of low and higher values of variables to ensures the Pharmaceutical product Quality by design (QbD) of manufacturing a finished product. The Quality by Design is depicted and a portion of its components recognized and process parameters with quality characteristics are identified for every unit activity. Advantages, openings and steps engaged with Quality by Design of Pharmaceutical items are depicted. The point of the pharmaceutical advancement is to plan a quality item and it’s assembling procedure to reliably convey the proposed execution of the item. Quality can't be tried into items however quality ought to be worked in by outline. It incorporates the Quality target item profile, basic quality traits and key parts of Quality by Design. It likewise gives correlation between item quality by end item testing and item quality by Quality by Design. The establishment of Quality by Design is ICH Guidelines. It depends on the ICH Guidelines Q8 for pharmaceutical improvement, Q9 for quality hazard administration, Q10 for pharmaceutical quality frameworks. It moreover gives utilization of Quality by Design in pharmaceutical improvement and assembling of pharmaceuticals.
Keywords: Quality by Design, Design Space, Target Product Quality Profile, Critical Quality Attributes
An overview about Hedychium spicatum: a review
Authors: Rasool Shafiqa , Maqbool Mudasir 
Published: February 2019

The Indian Himalayan Region (IHR) serves as tremendous repository of plant biodiversity which is derived from extreme altitudinal gradients and phenomenal geographic provinces and has been proved as the richest reservoir of medicinal plants and aromatic plants. The lavish range of plant biodiversity in IHR is supported by various landscape features that provide myriad of habitats. Hedychium spicatum Buch-Ham (Zingiberaceae), commonly known as spiked ginger lily, is found in the entire Himalayan region. Rhizome contains about 4% of essential oil and its phytochemical investigations have shown the presence of a variety of terpenoids (monoterpenoids, sesquiterpenoids and diterpenoids).Traditionally, the rhizomes are used in the treatment of respiratory disorders, fevers, tranquilizer, hypotensive, antispasmodic, CNS depressant, analgesic, anti-inflammatory, antimicrobial, antioxidant, antifungal, pediculicidal and cytotoxic activities. The family Zingiberaceae well known for its immense medicinal values is distributed widely throughout the tropics, particularly in Southeast Asia. Zingiberaceae family is an important natural resource that provides many useful products for food, spices, medicines, dyes, perfume and aesthetics. Ethnobiologically, H. spicatum is not commonly popular throughout the Indian Himalayan region, but multifarious uses are practised specifically in different regions. In this review, we will briefly explain about the various multi-faceted aspects about Hedychium spicatum.
Keywords: Hedychium spicatum, Chemical composition, Rhizomes, Zingiberaceae.
Fast Pattern Discovery in Healthcare Data Using Graphics Processors
Authors: Rao Naseem , Tanweer Safdar 
Published: February 2019

The mobile medical diagnosis and health monitoring system helps in managing the various chronic diseases like asthma, blood pressure and heart diseases etc. in consultation with the remotely available physicians by initiating the emergency call automatically on the physician’s mobile phone and providing the on-line vital medical parameters captured by the body area sensor network of the patient. We observed that a GPU based solution can outperform a CPU based solution by more than 30% in terms of speed up, while giving same accuracy of results, divided among healthy, normal and unhealthy patients. Finally, key parameter to model our health care data likestandard deviations of {1, 0.5, 0.5}, means of {(1, 1), (0, 0), (-1,-1)} are used to study healthy persons and unhealthy patients.
Keywords: Healthcare ; GPU; EEG; PCG; datastructure
INTERRELATION OF ALLELIC VARIANTS OF HEMOSTASIS SYSTEM GENES ON THE DEVELOPMENT AND COURSE OF LUPUS NEPHRITIS
Authors: Borisov E. N. , Ivanitsky L. V. , Samokhodskaya L. M. , Krasnova T. N. , Pavlikova E. P. , Kamalov A. A. 
Published: February 2019

THE AIM: to evaluate the effect of allelic variations in the hemostatic system genes on the development and course of lupus nephritis. PATIENTS AND METHODS. The study analyzed 100 patients with SLE Caucasians. 80 women and 20 men aged 16 to 73 years (mean age 37, ± 14 years). The duration of observation was for 73 patients over 5 years, for 18 – from 1 year to 5 years and for 9 – less than 1 year A rise in the level of creatinine in the blood above or equal to 2 mg / dl was considered a significant sign of impaired renal function. RESULTS. Among the patients included in the study, kidney damage was detected in 61 people (61%). In 33 of them (54.1%), a variant of renal pathology was observed according to the type of rapidly progressive lupus nephritis (BPVN). In patients with BH, mutations in the MTHFR (C677T) gene were statistically significantly more frequent (p = 0.033). The OR for the mutant genotype is 6.146 with 95% CI from 1.692 to 22.326. In patients with PWHD, mutations in the MTHFR (C677T) gene were statistically significantly more frequent (p = 0.031). The OR for the mutant genotype is 1.625 with 95% CI from 1.034 to 4.771. The five-year renal survival in carriers of the mutant allele of the MTHFR gene (C677T) is statistically significantly lower (72.8%) than in patients without this mutation (81.9%) (p = 0.027). Ten-year renal survival in carriers of the mutant allele of the MTHFR gene (C677T) is statistically significantly less (55.6%) than in patients without this mutation (70.5%) (p = 0.016). In patients with BH, mutations in the PAI-1 gene (4G / 5G 675) were statistically significantly more frequent (p = 0.046). OR for mutant genotype – 1.766 with 95% CI from 1.061 to 4.758. CONCLUSION. The mutant alleles of the MTHFR (C677T) and PAI-1 (4G / 5G 675) genes are likely to be associated with the development of BH. Polymorphism of the MTHFR gene (C677T) is associated with an unfavorable course of HH.
DETERMINING OF MONOCLONAL GAMMOPATHY IN NEPHROLOGICAL PATIENTS
Authors: Lysenko L. B. , Chebotareva N. V. , Mrykhin N. N. , Rameev V. V. , Androsova T. V. , Varshavsky V. V. , Kogarko I. N. , Roshchupkina S. V. 
Published: February 2019

BACKGROUND. Мonoclonal gammopathy (MG) is not only the state preceding of hematological neoplasms, but also associated with non- hematological diseases, in particular damage of kidneys. Earlier diagnosis of MG represents an important area in treating patients with renal diseases associated with MG. THE AIM: To determine the frequency of MG among therapeutic and nephrological patients for optimization of methods of their diagnosis and treatment. PATIENTS AND METHODS: In common, 11392 patients were analyzed within 4 years (2013-2016). The standard clinical examination was conducted. Method of an electrophoresis of proteins of serum of blood and the 24-hour urine, method of immunofixation of proteins of serum and urine, and method of free light chains definition in serum (Freelite) were used for MG identification. RESULTS: MG is diagnosed in 174 of 11392 patients: 49 % of men and 51 % of women aged from 18 up to 85 years. MG was found 2.1 times more often in nephrological patient than in patients of therapeutic departments. Among patients of this group, AL-amyloidosis with kidney involvement was diagnosed in 41 %, cryoglobulinemic glomerulonephritis – in 18 %, chronic glomerulonephritis – in 35 %, also there was small number of patients with light chain disease and cast-nephropathy. 86 % of nephrological patients had less than 5 g/l of monoclonal protein that corresponds oligo secretory MG, and at 46 % from them – less than 1 g/l, other 10 % had MG of 5-10 g/l, and only in 4.42 % of patients MG more 10g/l was defined. CONCLUSION: We conclude that MG, especially oligo secretory form, play a significant role in pathogenesis of renal damage. It is important to apply sensitive methods – immunofixation of proteins and method «Freelite» for nephrological patients.
Relationship of Ferritin Levels of Pregnant Women Who Had Fe Deficiency Anemia with Ferritin Levels and APGAR of the Neonates
Authors: Zuliyana Zuliyana , Yanwirasti Yanwirasti , Sri Yanti Roza 
Published: February 2019

Iron deficiency anemia in pregnant women can have a negative impact on the baby, such as placental development, low birth weight, prematurity, baby health, hypoxia, decreased immune status, possibility of having physiological disorders and infant growth. The aim of this study was to determine the relationship of ferritin levels of pregnant women who had Fe deficiency anemia with ferritin levels and Apgarof the neonates.This was a cross sectional study in the population of pregnant women who had Fe deficiency anemia and neonates who met the inclusion criteria taken by consecutive sampling technique in the working area of Lubuk Buaya Health Center, Ambacang Health Center and Ikur Koto Health Center. Examination of ferritin levels was carried out in the Biomedical Laboratory of Faculty of Medicine, Andalas University using ELISA method. Data were analyzed by Pearson Test and Mann-Whitney Test. The results of this study showed there was no significant relationship between maternal ferritin levels on neonatal ferritin r = 0.248, p = 0.204. It also showed that there was no relationship between maternal ferritin levels on APGAR p value = 0.199 and there was a significant relationship between neonatal ferritin levels on APGAR p value = 0.002. The conclusion of this study is that there was a positive relationship between maternal ferritin levels with neonatal ferritin levels, there was no significant relationship between maternal ferritin levels and APGAR score, there is a significant relationship betweenneonatal ferritin levels with APGAR score. By improving nutrition, socioeconomic, qualitative antenatal care, early referral of risky cases and iron supplementation can reduce the incidence of anemia.
Pengaruh Dukungan Kelompok Keluarga Sesama Penderita (family peer-led support group) terhadap Pencegahan Relaps Penderita Skizofrenia di Kabupaten Sleman, Yogyakarta
Authors: Ghofur Abdul 
Published: February 2019

Background. Psychoeducation conducted by professionals, not fully able to overcome the problems faced by families. Therefore, continuity of services at the community level has not run continuously and focused its efforts on empowering families in optimizing the role and function according to development tasks. Objectives. This study aims to determine the influence of the family support group of fellow patients (family peer-led support group) on the prevention of schizophrenia’s relapse. Method. This research method using a quasi-experimental design with pre and post control group. A sample of 36 families who have a schizophrenic patient who lived in Community Health Centres Godean I and Gamping II in Sleman district, which is divided into 18-person family in the treatment group and 18 families in the control group. Technics sampling with randomized control trials. Results. While indicators of relapse using the Positive and Negative Syndrome Scale (PANSS) before the intervention in the treatment group had a mean ± SD of 25.06 ± 11.79 after intervention mean ± SD of 24.28 ± 11.09; while the control group mean ± SD of 19.83 ± 5.38, after intervention mean ± SD of 27.61 ± 9.97. Based on bivariate analysis showed mean ± SD of 0.36 ± 6.40 (t: -2.112; Sig α (<0.05): 0.042; 95% CI: -16.788 to -0.322). Conclusion. Support family group of fellow patient (family peer-led support group) can reduce the risk of schizophrenia’s relapse.