bluuebunny/crossref_metadata_2025_split huggingface dataset:
Immunosuppressive Immature Myeloid Cell Generation Is Controlled by Glutamine Metabolism in Human Cancer
Authors: Wu Wen-Chao , Sun Hong-Wei , Chen Jing , OuYang Han-Yue , Yu Xing-Juan , Chen Hai-Tian , Shuang Ze-Yu , Shi Ming , Wang Zilian , Zheng Limin 
Published: August 2019

Abstract
Tumor-associated myeloid cells are one of the prominent components of solid tumors, serving as major immune regulators for the tumor microenvironment (TME) and an obstacle for immune-checkpoint blocking (ICB) therapy. However, it remains unclear how metabolic processes regulate the generation of suppressive myeloid cells in the TME. Here, we found that hematopoietic precursor cells are enriched in the tissues of several types of human cancer and can differentiate into immature myeloid cells (IMC). Tumor-infiltrating IMCs are highly immunosuppressive, glycolytic, and proliferative, as indicated by high levels of M-CSFR, Glut1, and Ki67. To elucidate the role of metabolism in regulating the generation of IMCs, we induced suppressive IMCs from hematopoietic precursor cells with GM-CSF and G-CSF in vitro. We found that the generation of suppressive IMCs was accompanied by increased glycolysis, but not affected by glucose deprivation due to alternative catabolism. Generation of IMCs relied on glutaminolysis, regardless of glucose availability. Glutamine metabolism not only supported the expansion of IMCs with glutamine-derived α-ketoglutarate but also regulated the suppressive capacity through the glutamate–NMDA receptor axis. Moreover, inhibition of glutaminase GLS1 enhanced the therapeutic efficacy of anti–PD-L1 treatment, with reduced arginase 1+ myeloid cells, increased CD8+, IFNγ+ and granzyme B+ T cells, and delayed tumor growth in an ICB-resistant mouse model. Our work identified a novel regulatory mechanism of glutamine metabolism in controlling the generation of suppressive IMCs in the TME.
Increase in Surface Friction Dominates the Observed Surface Wind Speed Decline during 1973–2014 in the Northern Hemisphere Lands
Authors: Zhang Zhengtai , Wang Kaicun , Chen Deliang , Li Jianping , Dickinson Robert 
Published: August 2019

AbstractDuring 1973–2014, a reduction trend in the observed surface wind speed (10 m) in the Northern Hemisphere lands has been widely reported; this reduction is referred to as “global stilling.” The primary determining factors of global stilling include atmospheric circulation, turbulent friction, and surface friction when ignoring the vertical influencing factors. Most of the existing studies on the attribution of global stilling do not take changing surface friction into account. In addition, there are other changes in the climate system, such as aerosol loading, which could have an impact on atmospheric circulation, but are not included in the majority of current models either. Here, we developed a novel approach based on modeled winds calculated from sea level pressure observations and applied the method to approximately 4000 weather stations in the Northern Hemisphere lands from 1973 to 2014 to attribute the stilling in the three factors. In our methods, we neglected the vertical influencing factors on surface wind speed but took the aerosols’ changes on atmospheric circulation and gradual urbanization effect on surface wind speed into account. We found that atmospheric circulation has dictated the monthly variation in surface wind speed during the past four decades. However, the increased surface friction dominates the long-term declining trend of wind stilling. Our studies had uncertainties while neglecting the influence of vertical factors on surface wind stilling, despite most of the existing studies showing their effect was minor compared to the three factors explored in our study.
Why Does Global Warming Weaken the Gulf Stream but Intensify the Kuroshio?
Authors: Chen Changlin , Wang Guihua , Xie Shang-Ping , Liu Wei 
Published: August 2019

ABSTRACT
The Kuroshio and Gulf Stream, the subtropical western boundary currents of the North Pacific and North Atlantic, play important roles in meridional heat transport and ocean–atmosphere interaction processes. Using a multimodel ensemble of future projections, we show that a warmer climate intensifies the upper-layer Kuroshio, in contrast to the previously documented slowdown of the Gulf Stream. Our ocean general circulation model experiments show that the sea surface warming, not the wind change, is the dominant forcing that causes the upper-layer Kuroshio to intensify in a warming climate. Forced by the sea surface warming, ocean subduction and advection processes result in a stronger warming to the east of the Kuroshio than to the west, which increases the isopycnal slope across the Kuroshio, and hence intensifies the Kuroshio. In the North Atlantic, the Gulf Stream slows down as part of the Atlantic meridional overturning circulation (AMOC) response to surface salinity decrease in the high latitudes under global warming. The distinct responses of the Gulf Stream and Kuroshio to climate warming are accompanied by different regional patterns of sea level rise. While the sea level rise accelerates along the northeastern U.S. coast as the AMOC weakens, it remains close to the global mean rate along the East Asian coast as the intensifying Kuroshio is associated with the enhanced sea level rise offshore in the North Pacific subtropical gyre.
Generation and Propagation of Near-Inertial Waves in a Baroclinic Current on the Tasmanian Shelf
Authors: Schlosser Tamara L. , Jones Nicole L. , Bluteau Cynthia E. , Alford Matthew H. , Ivey Gregory N. , Lucas Andrew J. 
Published: August 2019

AbstractNear-inertial waves (NIWs) are often an energetic component of the internal wave field on windy continental shelves. The effect of baroclinic geostrophic currents, which introduce both relative vorticity and baroclinicity, on NIWs is not well understood. Relative vorticity affects the resonant frequency feff, while both relative vorticity and baroclinicity modify the minimum wave frequency of freely propagating waves ωmin. On a windy and narrow shelf, we observed wind-forced oscillations that generated NIWs where feff was less than the Coriolis frequency f. If everywhere feff > f then NIWs were generated where ωmin < f and feff was smallest. The background current not only affected the location of generation, but also the NIWs’ propagation direction. The estimated NIW energy fluxes show that NIWs propagated predominantly toward the equator because ωmin > f on the continental slope for the entire sample period. In addition to being laterally trapped on the shelf, we observed vertically trapped and intensified NIWs that had a frequency ω within the anomalously low-frequency band (i.e., ωmin < ω < feff), which only exists if the baroclinicity is nonzero. We observed two periods when ωmin < f on the shelf, but the relative vorticity was positive (i.e., feff > f) for one of these periods. The process of NIW propagation remained consistent with the local ωmin, and not feff, emphasizing the importance of baroclinicity on the NIW dynamics. We conclude that windy shelves with baroclinic background currents are likely to have energetic NIWs, but the current and seabed will adjust the spatial distribution and energetics of these NIWs.
The Critical Role of Communities of Practice and Peer Learning in Scaling Hydroclimatic Information Adoption
Authors: Page Rebecca , Dilling Lisa 
Published: August 2019

Abstract
Significant effort has been put into advancing the use and usability of information products to support adaptation to drought and climate variability, particularly for the water supply sector. Evidence and experience show that advancing the usability of information through processes such as coproduction is time consuming for both providers and users of information. One challenge for boundary organizations and researchers interested in enhancing the usability of their information is how such processes might “scale” to all the potential organizations and individual managers that might possibly be able to benefit from improved climate information. This paper examines information use preferences and practices specifically among managers of small water systems in the Upper Colorado River basin, with an eye toward identifying new opportunities to effectively scale information usability and uptake among all water managers—regardless of location or capacity—in a resource-constrained world. We find that boundary organizations and other usable science efforts would benefit from capitalizing on the communities of practice that bind water managers together. Specifically, strategic engagement with larger, well-respected water systems as early adopters, supporting dissemination of successes and experiences with new information products among a broader community of water managers, and increasing well-respected water systems’ capacity to engage directly with rural systems may all serve as useful strategies to promote widespread distribution, access, and adoption of information.
Effects of Fatigue on Balance Recovery From Unexpected Trips
Authors: Qu Xingda , Xie Yongxun , Hu Xinyao , Zhang Hongbo 
Published: August 2019

Objective The objective was to examine how physical fatigue and mental fatigue affected balance recovery from unexpected trips. Background Trips are the leading cause for occupational falls that are a multifactorial problem. Recognizing risk factors is the first step in accident control. Fatigue is one of the most common task-related risk factors for occupational falls. Fatigue typically can be divided into physical fatigue and mental fatigue, both of which are common in occupational settings. Method One hundred eight young volunteers participated in the experiment. They were evenly divided into three groups: no fatigue group, physical fatigue group, and mental fatigue group. Each participant performed four walking trials on a linear walkway at their self-selected normal speed. The first three trials were normal walking trials. A trip was induced to participants in the fourth walking trial using a metal pole. Balance recovery from unexpected trips was characterized by trunk flexion and first recovery step measures. Results Recovery step length was smaller and maximum trunk flexion became larger in the mental fatigue group compared with those in the no fatigue group. Physical fatigue did not significantly affect trunk flexion and first recovery step measures. Conclusion Mental fatigue increased the likelihood of loss of balance. Thus, mental fatigue could be a risk factor for trips and falls. To prevent trip-related falls, interventions should be adopted to prevent prolonged exposures to cognitively demanding activities in occupational settings.
Explanatory models of mental illness among family caregivers of persons in psychiatric rehabilitation services: A pilot study
Authors: Mathews Manila , Bhola Poornima , Herbert Hesi , Chaturvedi Santosh K 
Published: August 2019

Background: Understanding the explanatory models of family caregivers is particularly important in interdependent contexts like India, where they often play a significant role in the help-seeking behaviours, treatment decision-making and long-term care of those diagnosed with mental illness. Aims: This study was planned to explore the diversity of explanatory models among family caregivers at a centre for recovery-oriented rehabilitation services in South India. Methods: The sample for this study included 60 family caregivers of patients referred to Psychiatric Rehabilitation Services within a tertiary-care hospital for mental health and neurosciences. Bart’s Explanatory Model Inventory, including a semi-structured interview and a checklist, assessed the family caregivers’ explanatory model of distress on five domains: identity, cause, timeline, consequences and control/cure/treatment. Results: The results indicated the coexistence of multiple causal explanatory models including psychosocial, supernatural, situational and behavioural contributors. While 36.7% of the caregivers displayed two explanatory models, 33.3% of the caregivers held three explanatory models and 16.6% of the caregivers endorsed four explanatory models. Caregivers shared their concerns about varied consequences of mental illness but less than half of them were aware of the name of the psychiatric disorder. While they accessed various forms of treatments and adjunctive supports such as prayer, medication was the most frequently used treatment method. Conclusions: The findings have implications for collaborative goal setting in recovery-oriented services for persons with mental illness and their families.
Association of Midlife Hypertension with Late‐Life Hearing Loss
Authors: Reed Nicholas S. , Huddle Matthew G. , Betz Joshua , Power Melinda C. , Pankow James S. , Gottesman Rebecca , Richey Sharrett A. , Mosley Thomas H. , Lin Frank R. , Deal Jennifer A. 
Published: August 2019

ObjectiveTo investigate the association of midlife hypertension with late‐life hearing impairment.Study DesignData from the Atherosclerosis Risk in Communities study, an ongoing prospective longitudinal population‐based study (baseline, 1987‐1989).SettingWashington County, Maryland, research field site.Subjects and MethodsSubjects included 248 community‐dwelling men and women aged 67 to 89 years in 2013. Systolic blood pressure (SBP) and diastolic blood pressure were measured at each of 5 study visits from 1987‐1989 to 2013. Hypertension was defined by elevated systolic or diastolic blood pressure or antihypertensive medication use. A 4‐frequency (0.5‐4 kHz) better‐hearing ear pure tone average in decibels hearing loss (dB HL) was calculated from pure tone audiometry measured in 2013. A cutoff of 40 dB HL was used to indicate clinically significant moderate to severe hearing impairment. Hearing thresholds at 5 frequencies (0.5‐8 kHz) were also considered separately.ResultsForty‐seven participants (19%) had hypertension at baseline (1987‐1989), as opposed to 183 (74%) in 2013. The SBP association with late‐life pure tone average differed by the time of measurement, with SBP measured at earlier visits associated with poorer hearing; the difference in pure tone average per 10–mm Hg SBP measured was 1.43 dB HL (95% CI, 0.32‐2.53) at baseline versus −0.43 dB HL (95% CI, −1.41 to 0.55) in 2013. Baseline hypertension was associated with higher thresholds (poorer hearing) at 4 frequencies (1, 2, 4, 8 kHz).ConclusionMidlife SBP was associated with poorer hearing measured 25 years later. Further analysis into the longitudinal relationship between hypertension and hearing impairment is warranted.
Effect of Concussions on the Performance of Running Backs and Wide Receivers in the National Football League
Authors: Jildeh Toufic R. , Okoroha Kelechi R. , Taylor Kevin A. , Buckley Patrick , Mehta Samir , Mehran Nima , Moutzouros Vasilios 
Published: August 2019

Background: Concussion injuries are common in professional football players; however, their effect on player performance remains unclear. Purpose: To quantify the effect of concussions on the performance of running backs and wide receivers in professional football players. Study Design: Cohort study; Level of evidence, 3. Methods: Concussion data from the National Football League were collected for a period of 4 seasons (2012-2015) for running backs and wide receivers. Age, experience, position, time to return to play, yearly total yards, and touchdowns were recorded. A power rating (total yards divided by 10 plus touchdowns multiplied by 6) was calculated for each player’s injury season as well as for the 3 seasons before and after their respective injury. A control group of running backs and wide receivers without an identified concussion injury who competed in the 2012 season was assembled for comparison. Player performance up to 3 seasons before and after the injury season was examined to assess acute and longitudinal changes in player performance. Results: A total of 38 eligible running backs and wide receivers sustained a concussion during the study period. Thirty-four (89%) players were able to return to competition in the same season, missing an average of 1.5 ± 0.9 games; the remaining 4 players returned in the subsequent season. Power ratings for concussed players were similar to those of controls throughout the study period. Concussed players did not suffer an individual performance decline upon returning within the same season. Furthermore, no significant difference in change of power rating was observed in concussed players in the acute (±1 year from injury; −1.2 ± 4.8 vs –1.1 ± 3.9, P = .199) or chronic (±3 years from injury; –3.6 ± 8.0 vs –3.0 ± 4.5, P = .219) setting compared with controls. All concussed players successfully returned to competition in either the index or next season. Conclusion: A high rate of National Football League running backs and wide receivers are able to return to play after a concussion injury. These players were found to perform at a similar level in both the acute and long-term period after concussion.
Characteristics and safety of tattoos in patients with systemic lupus erythematosus
Authors: Sabio J M , Betolaza S De , Vargas-Hitos J A 
Published: August 2019

Objective The objective of this study was to determine the safety of tattoos in patients with systemic lupus erythematosus (SLE). Methods Patients ( N = 147; ≤55 years; 92% women) were asked if they had tattoos. The characteristics of the tattoos and the immediate complications were investigated and compared with those of a matched control group. We examined retrospectively after the tattoo was completed whether there had been flare-ups or increased organ damage (Systemic Lupus International Collaborating Clinics/American Collage of Rheumatology Damage Index (SDI)). Finally, we compared the SLE-related characteristics of patients with and without tattoos. Results Twenty-eight patients (19%, 26 women, median (interquartile range) age 33 (25–42) years, 65 tattoos in total) had ≥1 tattoo. At the time the tattoo was done the median (interquartile range) SLEDAI and SDI were 2 (0–2) and 0 (0–1), respectively. The characteristics of the tattoos were similar to those of controls. No patients experienced acute complications. After a median follow-up of 17 (12–20) months (3 (2–4) visits/year) four patients had five mild-to-moderate flare-ups. The median time between the tattoo and the flare-up was 9 (6–14) months. No increase in SDI was observed. The SLE-related characteristics of patients with and without tattoos were similar. Conclusion Tattoos seem to be safe in SLE patients with inactive or low active disease.
Decision-Making in Cleft-Related Surgery: A Qualitative Analysis of Patients and Caregivers
Authors: Bennett Katelyn G. , Patterson Annie K. , Schafer Kylie , Haase Madeleine , Ranganathan Kavitha , Carlozzi Noelle , Vercler Christian J. , Kasten Steven J. , Buchman Steven R. , Waljee Jennifer F. 
Published: August 2019

Objective: Preference-sensitive surgical decisions merit shared decision-making, as decision engagement can reduce decisional conflict and regret. Elective cleft-related procedures are often preference sensitive, and therefore, we sought to better understand decision-making in this population. Design: Semistructured interviews were conducted to elicit qualitative data. A hierarchical codebook was developed through an iterative process in preparation for thematic analysis. Thematic analysis was performed to examine differences between patients and caregivers. Setting: Multidisciplinary cleft clinic at a tertiary care center. Participants: Patients with cleft lip aged 8 and older (n = 31) and their caregivers (n = 31) were purposively sampled. Inability to converse in English, intellectual disability, or syndromic diagnoses resulted in exclusion. Main Outcome Measures: Preferences surrounding surgical decision-making identified during thematic analysis. Results: Mean patient age was 12.7 (standard deviation: 3.1). Most had unilateral cleft lip and palate (43.8%). Three themes emerged: Insufficient Understanding of Facial Difference and Treatment, Diversity of Surgical Indications, and Barriers to Patient Autonomy. Almost half of caregivers believed their children understood their clefts, but most of these children failed to provide information about their cleft. Although many patients and caregivers acknowledged that surgery addressed function and/or appearance, patients and caregivers exhibited differences regarding the necessity of surgery. Furthermore, a large proportion of patients believed their opinions mattered in decisions, but less than half of caregivers agreed. Conclusions: Patients with clefts desire to participate in surgical decisions but have limited understanding of their facial difference and surgical indications. Cleft surgeons must educate patients and facilitate shared decision-making.
Tourism and Foreign Direct Investment Inflows in Sri Lanka
Authors: Ravinthirakumaran K. , Selvanathan E. A. , Selvanathan S. , Singh T. 
Published: August 2019

This article examines the relationship between tourism and foreign direct investment (FDI) and the factors that enhance tourism in Sri Lanka using data over the years 1978–2015, under a vector autoregressive framework. The results reveal that there is a significant long-run equilibrium relationship between tourism, and a number of variables such as FDI, exchange rate, tourism price and civil war of the country. The results also reveal that there exist unidirectional causal relationships from FDI to tourism and tourism price to tourism, in both the long run and the short run. In light of this finding, it is recommended that Sri Lanka should introduce policies that would increase FDI inflows into the tourism industry and maintain a competitive tourism price to attract more tourist arrivals. JEL: C32, F19, F41, O53
The effect of the delay between injury and surgery on mortality, morbidity, and complications in craniospinal gunshot wounding
Authors: Sertbaş İdris , Karatay Mete 
Published: August 2019

Introduction The effect of the surgical approach and the duration between the trauma and surgery on the complications, morbidity, and mortality in cranial and spinal penetrating gunshot injuries are investigated. Methods Evaluation of 63 patients from the Libyan civil war who were referred to the İstanbul Yeni Yüzyıl University Gaziosmanpaşa Hospital neurosurgery clinic for the treatment and surgery between 2015 and 2017. Results Complications such as meningitis, superficial infection, and abscess developed in 31% of the patients who underwent surgery within the initial 24 h, 58% of the patients who underwent surgery between 24 and 72 h and in all patients who underwent surgery after 72 h. While an improvement was seen in all 14 patients who had preoperative paresis and underwent surgery within 24 h or between 24 and 72 h, only one of the six patients who had paresis and underwent surgery after 72 h improved. One of the patients who underwent surgery within 24 h, three of those who underwent surgery between 24 and 72 h, and four of those who underwent surgery after 72 h died. Conclusion The complications, morbidity, and mortality increase with a prolonged duration between the injury and surgery after craniospinal gunshot wounding.