bluuebunny/crossref_metadata_2025_split huggingface dataset:
Interleukin-6 selectively induces drug metabolism to potentiate the genotoxicity of dietary carcinogens in mammary cells
Authors: Malik Durr-e-shahwar , David Rhiannon M. , Gooderham Nigel J. 
Published: September 2019

AbstractBreast cancer is the most commonly diagnosed malignancy in females, the etiology being multifactorial and includes the role of lifestyle exposure to DNA-damaging chemicals such as dietary carcinogens benzo (a) pyrene (BaP) and 2-amino-1-methyl-6-phenylimidazo [4, 5-b] pyridine (PhIP). Both compounds require cytochrome P450 (CYP)-mediated metabolic activation to DNA-damaging species, and both induce transcriptional responses through the nuclear receptors Aryl hydrocarbon receptor (AhR) and estrogen receptor α (ERα). BaP and PhIP are mammary carcinogens in rodents. Clinically, circulating IL-6 expression is linked with poor prognosis of cancer and 35% of the deaths in breast cancer are linked with inflammation. The objective of this work was to investigate the molecular toxicology and local activation of BaP and PhIP in the presence of IL-6. Our laboratory has previously reported that miR27b can regulate CYP1B1 expression in colorectal cells, here we have investigated if this mechanism is working in mammary cell models, MCF-7 and MDA-MB-231 cells. Treatment (24 h) of cells with BaP (10 nM-10 µM) and PhIP (100 nM-100 µM) significantly induced genetic damage (micronuclei formation) in a dose-dependent manner in both cell lines. This effect was potentiated in the presence of human IL-6 at concentrations reported to be expressed in clinical breast cancer. On its own, IL-6 treatment failed to induce micronuclei frequency above the control levels in these cells. Compared to BaP or PhIP treatment alone, IL-6 plus BaP or PhIP selectively induced CYP1B1 significantly in both cell lines. Additionally, miR27b expression was downregulated by IL-6 treatments and transfection with miR27b inhibitor confirmed that miR27b is a regulator of CYP1B1 in both cell lines. These data show that BaP- and PhIP-induced DNA damage in mammary cells is potentiated by the inflammatory cytokine IL-6 and that inflammation-induced CYP expression, specifically CYP1B1 via miR27b, is responsible for this effect.
Systematic comparison of post-column isotope dilution using LC-CO-IRMS with qNMR for amino acid purity determination
Authors: Dunn Philip J. H. , Malinovsky Dmitry , Achtar Eli , Clarkson Cailean , Goenaga-Infante Heidi 
Published: September 2019

Abstract
Determination of the purity of a substance traceable to the International System of Units (SI) is important for the production of reference materials affording traceability in quantitative measurements. Post-column isotope dilution using liquid chromatography-chemical oxidation-isotope ratio mass spectrometry (ID-LC-CO-IRMS) has previously been suggested as a means to determine the purity of organic compounds; however, the lack of an uncertainty budget has prevented assessment of the utility this approach until now. In this work, the previously published ID-LC-CO-IRMS methods have not only been improved by direct gravimetric determination of the mass flow of 13C-labelled spike but also a comprehensive uncertainty budget has been established. This enabled direct comparison of the well-characterised ID-LC-CO-IRMS method to quantitative nuclear magnetic resonance spectroscopy (qNMR) for purity determination using valine as the model compound. The ID-LC-CO-IRMS and qNMR methods provided results that were in agreement within the associated measurement uncertainty for the purity of a sample of valine of (97.1 ± 4.7)% and (99.64 ± 0.20)%, respectively (expanded uncertainties, k = 2). The magnitude of the measurement uncertainty for ID-LC-CO-IRMS determination of valine purity precludes the use of this method for determination of purity by direct analysis of the main component in the majority of situations; however, a mass balance approach is expected to result in significantly improved measurement uncertainty.
Needle Tract Implantation Following Fine‐Needle Aspiration of Thyroid Cancer
Authors: Hayashi Toshitetsu , Hirokawa Mitsuyoshi , Higuchi Miyoko , Kudo Takumi , Ito Yasuhiro , Miyauchi Akira 
Published: September 2019

AbstractBackgroundNeedle tract implantation (NTI) can occur after thyroid fine‐needle aspiration cytology (FNAC). To date, no studies enrolling a large number of patients and studying the cumulative incidence (CI) of NTI have been published. This study analyzed the clinicopathological features of NTI and calculated the CI.MethodsA total of 11,745 patients who underwent first FNAC, resection for thyroid carcinomas and related lymph node metastases, and postoperative ultrasonography in Kuma Hospital between 2006 and 2017 were evaluated. NTI was defined as macroscopically visible and/or sonographically detected recurrent tumors at the sites of the previous aspiration. Lymphovascular invasion and/or nodal metastasis were excluded.ResultsWe found 22 NTI‐THY (originated from aspiration of thyroid tumors) and 8 NTI‐LN (originating from lymph nodes) cases with CI of 0.15% and 0.37%, and 0.37% and 0.58% at 5 and 10 years after FNAC, respectively. A large percentage (53%) of cases are presented as more aggressive histologic subtypes than their original tumors. Of these NTI patients, 4 (12.1%) died of disease and 10 (33.3%) developed distant metastases but remained alive with stable disease, three (9.1%) developed local recurrences, and the remaining 15 (10%) were free of recurrence.ConclusionsWe demonstrated for the first time the CI and detailed clinicopathological features of thyroid NTI associated with possible histological transformation. Despite the low CI, the risk of death and distant metastases increase manifold in NTI patients than that in patients without recurrence. Therefore, NTI could be an important prognostic variable and impact patient survival.
Anterolateral thigh free flap in reconstruction of lateral skull base defects after oncological resection
Authors: Trojanowski Piotr , Szymański Marcin , Trojanowska Agnieszka , Andrzejczak Adrian , Szczepanek Dariusz , Klatka Janusz 
Published: September 2019

Abstract

Purpose
Evaluation of the utility of the free anterolateral thigh flap reconstruction of the defects resulting from radical temporal bone resection in the management of lateral skull base malignancies in a single institution.

Methods
An analysis of 17 en bloc subtotal petrosectomies for removal of malignant tumours was performed. There were 12 squamous cell carcinomas, 4 basal cell carcinomas and 1 adenoid cystic carcinoma. The tumours were staged with the University of Pittsburgh TNM system. In all patients, the lateral temporal bone with the preservation of the petrous apex and carotid artery was performed. All patients had parotid gland resection. The post-resection defect was reconstructed with an ALT free flap.

Results
Tumour radical resection and defect reconstruction with an ALT flap was achieved in all patients without intraoperative complications. The transplants were harvested as fasciocutaneous flaps, 11 perfused by musculocutaneous and 6 by septocutaneous perforators. The ALT flaps had a mean pedicle length of 8 cm (6–12 cm), and the flap size ranged between 6 × 15 cm and 15 × 30 cm. The flaps were supplied by nine facial, five occipital and three maxillary arteries. Recipient-site veins included eight internal jugular, seven facial, one retromandibular and one external jugular vein. All arterial pedicles were anastomosed in an end-to-end manner. The veins were anastomosed with interrupted sutures and in 11 cases with Synovis-Coupler® devices. All the flap transfers were performed successfully. Three patients experienced postoperative complications.

Conclusions
The ALT flap proved to be effective for covering large temporal skull base defects resulting from the radical removal of temporal bone malignancies. The functional and cosmetic results were acceptable with a low complication rate.
What goes up must come down: insights from studies on descending controls acting on spinal pain processing
Authors: Lockwood Stevie , Dickenson Anthony H. 
Published: September 2019

AbstractDescending controls link higher processing of noxious signals to modulation of spinal cord responses to their noxious inputs. It has become possible to study one key inhibitory system in animals and humans using one painful stimulus to attenuate another distant response and so eliciting diffuse noxious inhibitory controls (DNIC) or the human counterpart, conditioned pain modulation (CPM). Here, we discuss the neuronal pathways in both species, their pharmacology and examine changes in descending controls with a focus on osteoarthritis. We will also discuss the opposing descending facilitatory system. Strong parallels between DNIC and CPM emphasize the possibility of forward and reverse translation.
Analysis of the quinoa genome reveals conservation and divergence of the flowering pathways
Authors: Golicz Agnieszka A. , Steinfort Ursula , Arya Hina , Singh Mohan B. , Bhalla Prem L. 
Published: September 2019

Abstract
Quinoa (Chenopodium quinoa Willd.) is a grain crop grown in the Andes renowned as a highly nutritious plant exhibiting tolerance to abiotic stress such as drought, cold and high salinity. Quinoa grows across a range of latitudes corresponding to differing day lengths, suggesting regional adaptations of flowering regulation. Improved understanding and subsequent modification of the flowering process, including flowering time, ensuring high yields, is one of the key factors behind expansion of cultivation zones and goals of the crop improvement programs worldwide. However, our understanding of the molecular basis of flower initiation and development in quinoa is limited. Here, we use a computational approach to perform genome-wide identification and analysis of 611 orthologues of the Arabidopsis thaliana flowering genes. Conservation of the genes belonging to the photoperiod, gibberellin and autonomous pathways was observed, while orthologues of the key genes found in the vernalisation pathway (FRI, FLC) were absent from the quinoa genome. Our analysis indicated that on average each Arabidopsis flowering gene has two orthologous copies in quinoa. Several genes including orthologues of MIF1, FT and TSF were identified as homologue-rich genes in quinoa. We also identified 459 quinoa-specific genes uniquely expressed in the flower and/or meristem, with no known orthologues in other species. The genes identified provide a resource and framework for further studies of flowering in quinoa and related species. It will serve as valuable resource for plant biologists, crop physiologists and breeders to facilitate further research and establishment of modern breeding programs for quinoa.
The impact of body size changes on recurrence risk depends on age and estrogen receptor status in primary breast cancer
Authors: Tryggvadottir Helga , Ygland Rödström Maria , Markkula Andrea , Kenéz Xuyian , Isaksson Karolin , Borgquist Signe , Jernström Helena 
Published: September 2019

Abstract

Purpose
To investigate the prognostic impact of body size changes during the first postoperative year in breast cancer.

Methods
A cohort of 1,317 primary breast cancer patients included in Sweden (2002–2014) underwent body size measurements at the preoperative and 1-year visits (n = 1,178). Landmark survival analyses were used to investigate how postoperative weight gain or loss (> 5%) or change in waist–hip ratio (WHR) categories (≤ 0.85 or > 0.85) impact prognosis.

Results
Median age at inclusion was 61 years and body mass index 25.1 kg/m2. After a median follow-up of 5.0 years from inclusion, 165 recurrences and 77 deaths occurred. Weight gain (17.0%) conferred over twofold recurrence risk only in patients < 50 years (Pinteraction = 0.033). Weight loss (8.6%) was only associated with a poor prognosis in patients ≥ 70 years, but not after restriction analysis. Weight change did not impact prognosis in patients 50 to < 70 years. Changes between WHR categories were associated with differential recurrence risk depending on estrogen receptor (ER) status (Pinteraction = 0.007), with higher recurrence risk in patients with ER+ tumors and lower recurrence risk with ER− tumors.

Conclusion
Both changes in terms of weight and WHR category yielded independent prognostic information. Further research is imperative before recommending weight loss for all overweight breast cancer patients.
Routine Cognitive Behavioural Therapy for Anxiety and Depression is More Effective at Repairing Symptoms of Psychopathology than Enhancing Wellbeing
Authors: Widnall Emily , Price Alice , Trompetter Hester , Dunn Barnaby D. 
Published: September 2019

AbstractThe primary focus of classic cognitive behavioural therapy (CBT) for depression and anxiety is on decreasing symptoms of psychopathology. However, there is increasing recognition that it is also important to enhance wellbeing during therapy. This study investigates the extent to which classic CBT for anxiety and depression leads to symptom relief versus wellbeing enhancement, analysing routine outcomes in patients receiving CBT in high intensity Improving Access to Psychological Therapy (IAPT) Services in the UK. At intake, there were marked symptoms of anxiety and depression (a majority of participants scoring in the severe range) and deficits in wellbeing (a majority of participants classified as languishing, relative to general population normative data). CBT was more effective at reducing symptoms of anxiety and depression than repairing wellbeing. As a result, at the end of treatment, a greater proportion of participants met recovery criteria for anxiety and depression than had moved from languishing into average or flourishing levels of wellbeing. Given the importance of wellbeing to client definitions of recovery, the present results suggest a greater emphasis should be placed on enhancing wellbeing in classic CBT.
On the Use of Electromagnetics for Earth Imaging of the Polar Regions
Authors: Hill Graham J. 
Published: September 2019

Abstract
The polar regions are host to fundamental unresolved challenges in Earth studies. The nature of these regions necessitates the use of geophysics to address these issues, with electromagnetic and, in particular, magnetotelluric studies finding favour and being applied over a number of different scales. The unique geography and climatic conditions of the polar regions means collecting magnetotelluric data at high latitudes, which presents challenges not typically encountered and may result in significant measurement errors. (1) The very high contact resistance between electrodes and the surficial snow and ice cover (commonly MΩ) can interfere with the electric field measurement. This is overcome by using custom-designed amplifiers placed at the active electrodes to buffer their high impedance contacts. (2) The proximity to the geomagnetic poles requires verification of the fundamental assumption in magnetotellurics that the magnetic source field is a vertically propagating, horizontally polarised plane wave. Behaviour of the polar electro-jet must be assessed to identify increased activity (high energy periods) that create strong current systems and may generate non-planar contributions. (3) The generation of ‘blizstatic’, localised random electric fields caused by the spin drift of moving charged snow and ice particles that produce significant noise in the electric fields during periods of strong winds. At wind speeds above ~ 10 m s−1, the effect of the distortion created by the moving snow is broad-band. Station occupation times need to be of sufficient length to ensure data are collected when wind speed is low. (4) Working on glaciated terrain introduces additional safety challenges, e.g., weather, crevasse hazards, etc. Inclusion of a mountaineer in the team, both during the site location planning and onsite operations, allows these hazards to be properly managed. Examples spanning studies covering development and application of novel electromagnetic approaches for the polar regions as well as results from studies addressing a variety of differing geologic questions are presented. Electromagnetic studies focusing on near-surface hydrologic systems, glacial and ice sheet dynamics, as well as large-scale volcanic and tectonic problems are discussed providing an overview of the use of electromagnetic methods to investigate fundamental questions in solid earth studies that have both been completed and are currently ongoing in polar regions.
Truth Diagrams Versus Extant Notations for Propositional Logic
Authors: Cheng Peter C.-H. 
Published: September 2019

Abstract
Truth diagrams (TDs) are introduced as a novel graphical representation for propositional logic (PL). To demonstrate their epistemic efficacy a set of 28 concepts are proposed that any comprehensive representation for PL should encompass. TDs address all the criteria whereas seven other existing representations for PL only provide partial coverage. These existing representations are: the linear formula notation, truth tables, a PL specific interpretation of Venn Diagrams, Frege’s conceptual notation, diagrams from Wittgenstein’s Tractatus, Pierce’s alpha graphs and Gardner’s shuttle diagrams. The comparison of the representations succeeds in distinguishing ideas that are fundamental to PL from features of common PL representations that are somewhat arbitrary.
Rhythmic Features of Movement Synchrony for Bonding Individuals in Dyadic Interaction
Authors: Fujiwara Ken , Kimura Masanori , Daibo Ikuo 
Published: September 2019

AbstractThis study examined ways in which rhythmic features of movement contribute to bonding between individuals. Though previous studies have described synchrony as a form of social glue, this research extends those findings to consider the impact of fast versus slow tempo on movement synchrony. This two-part experiment examined dyadic interactions as they occurred between same-sex strangers (Study 1) and friends (Study 2). Participants were video-recorded as they engaged in 5- or 6-min chats, and synchrony was evaluated using wavelet transform via calculations of cross-wavelet coherence. Study 1 employed regression commonality analysis and hierarchical linear modeling and found that among various frequency bands, rapport between individuals was positively associated with synchrony under 0.025 Hz (i.e., slower than once every 40 s) and 0.5–1.5 Hz (i.e., once every 0.67–2 s). On the contrary, Study 2 determined that synchrony of 0.5–1.5 Hz was not impactful among friend dyads and only predictive of the motivation to cultivate a friendly relationship during interactions with strangers. These results indicate the existence of a distinctive rhythm for bonding individuals, and the role of pre-existing friendship as a moderator of the bonding effect of synchrony. However, the role of relative phase (i.e., timing of movement; same versus opposite timing) remains unclear, as the ratio of in- and anti-phase patterning had no significant influence on perceived rapport and motivation to develop relationships. On the basis of the research results, a theoretical contribution is proposed to the study of interpersonal coordination.
The future is not always open
Authors: Grant James D. E. , Kunzinger Michael , Sämann Clemens , Steinbauer Roland 
Published: September 2019

AbstractWe demonstrate the breakdown of several fundamentals of Lorentzian causality theory in low regularity. Most notably, chronological futures (defined naturally using locally Lipschitz curves) may be non-open and may differ from the corresponding sets defined via piecewise$$C^1$$C1-curves. By refining the notion of a causal bubble from Chruściel and Grant (Class Quantum Gravity 29(14):145001, 2012), we characterize spacetimes for which such phenomena can occur, and also relate these to the possibility of deforming causal curves of positive length into timelike curves (push-up). The phenomena described here are, in particular, relevant for recent synthetic approaches to low-regularity Lorentzian geometry where, in the absence of a differentiable structure, causality has to be based on locally Lipschitz curves.
On the Whittle estimator for linear random noise spectral density parameter in continuous-time nonlinear regression models
Authors: Ivanov A. V. , Leonenko N. N. , Orlovskyi I. V. 
Published: September 2019

Abstract
A continuous-time nonlinear regression model with Lévy-driven linear noise process is considered. Sufficient conditions of consistency and asymptotic normality of the Whittle estimator for the parameter of spectral density of the noise are obtained in the paper.
Approaches and Alternatives to the Wealth Index to Measure Socioeconomic Status Using Survey Data: A Critical Interpretive Synthesis
Authors: Poirier Mathieu J. P. , Grépin Karen A. , Grignon Michel 
Published: September 2019

Abstract
Monitoring progress towards the Sustainable Development Goals by 2030 requires the global community to disaggregate targets along socio-economic lines, but little has been published critically analyzing the appropriateness of wealth indices to measure socioeconomic status in low- and middle-income countries. This critical interpretive synthesis analyzes the appropriateness of wealth indices for measuring social health inequalities and provides an overview of alternative methods to calculate wealth indices using data captured in standardized household surveys. Our aggregation of all published associations of wealth indices indicates a mean Spearman’s rho of 0.42 and 0.55 with income and consumption, respectively. Context-specific factors such as country development level may affect the concordance of health and educational outcomes with wealth indices and urban–rural disparities can be more pronounced using wealth indices compared to income or consumption. Synthesis of potential future uses of wealth indices suggests that it is possible to quantify wealth inequality using household assets, that the index can be used to study SES across national boundaries, and that technological innovations may soon change how asset wealth is measured. Finally, a review of alternative approaches to constructing household asset indices suggests lack of evidence of superiority for count measures, item response theory, and Mokken scale analysis, but points to evidence-based advantages for multiple correspondence analysis, polychoric PCA and predicted income. In sum, wealth indices are an equally valid, but distinct measure of household SES from income and consumption measures, and more research is needed into their potential applications for international health inequality measurement.
Bonding or Bridging? Volunteering Among the Members of Six Thriving Evangelical Congregations in the Netherlands
Authors: Vermeer Paul , Scheepers Peer 
Published: September 2019

Abstract
The rise of conservative religion in the West threatens the enduring positive contribution of religion to civil society, if conservative churches, as often assumed, indeed generate more bonding than bridging social capital. Against this background, this study explores the civic engagement of evangelicals in the Netherlands. Two research questions are addressed: (1) To what extent are Dutch evangelicals more involved in religious than non-religious volunteering as compared to mainline Christians and non-church members? and (2) Which decisive factors determine the religious and non-religious volunteering of Dutch evangelicals as compared to mainline Christians and non-church members? Results show that these orthodox Christians are more involved in religious than in non-religious volunteering. Their religious volunteering is determined by their church attendance, Bible reading and social embeddedness in their congregation, while their non-religious volunteering is impeded by their mono-religious orientation and social embeddedness in their congregation and by the volunteering of their parents.