bluuebunny/crossref_metadata_2025_split huggingface dataset:
Self- and Parent-Reported Fatigue 7 Years After Severe Childhood Traumatic Brain Injury: Results of the Traumatisme Grave de l'Enfant Prospective Longitudinal Study
Authors: Câmara-Costa Hugo , Francillette Leila , Opatowski Marion , Toure Hanna , Brugel Dominique , Laurent-Vannier Anne , Meyer Philippe , Dellatolas Georges , Watier Laurence , Chevignard Mathilde 
Published: July 2019

Objective:
To investigate presence of and factors associated with self- and parent-reported fatigue 7 years after severe childhood traumatic brain injury (TBI) in the prospective longitudinal study TGE (Traumatisme Grave de l'Enfant—severe childhood trauma).

Methods:
Self-reports and/or parent reports on the Multidimensional Fatigue Scale were collected for 38 participants (aged 7-22 years) 7 years after severe childhood TBI, and 33 controls matched for age, gender, and parental educational level. The data collected included sociodemographic characteristics, age at injury and injury severity scores, overall disability (Glasgow Outcome Scale Extended), intellectual outcome (Wechsler scales), and questionnaires assessing executive functions, health-related quality of life, behavior, and participation.

Results:
Fatigue levels were significantly worse in the TBI than in the control group, especially for cognitive fatigue. Correlations of reported fatigue with age at injury, gender, TBI severity, and intellectual ability were moderate and often not significant. Fatigue was significantly associated with overall level of disability (Glasgow Outcome Scale Extended) and with all questionnaires completed by the same informant.

Conclusion:
High levels of fatigue were reported by 30% to 50% of patients 7 years after a severe childhood TBI. Reported fatigue explained more than 60% of the variance of reported health-related quality of life by the same informant (patient or parent).
Antiphospholipid syndrome in pediatric patients
Authors: Tarango Cristina , Palumbo Joseph S. 
Published: July 2019

Purpose of review
The purpose of this review is to summarize the diagnosis and management of the antiphospholipid syndrome (APS) in children.

Recent findings
APS is a rare, acquired autoimmune systemic disease that can result in significant morbidity in children related to vascular thrombosis. The diagnosis and management of APS in children can be challenging due to a lack of validated diagnostic criteria and the rarity of the disease. In addition, many healthy children have transient circulating antiphospholipid antibodies without thrombotic complications. Nevertheless, epidemiological studies suggest that APS represents a greater relative proportion of thrombotic disease in children than it does in adults. Management of pediatric APS is largely inferred from adult data despite unique characteristics of pediatric APS. The current recommendations include long-term anticoagulation, which can be problematic in young, active individuals. There is little data on potential benefits of nonantithrombotic therapy in the management of pediatric APS.

Summary
Data on pediatric APS are limited, but evidence suggests that using current available diagnostic testing is valuable and, until further evidence is available, treating thrombotic complications with heparins or warfarin should be standard of care.
Recent advances in inherited platelet disorders
Authors: Pluthero Fred G. , Kahr Walter H.A. 
Published: July 2019

Purpose of review
The increasing use of high throughput sequencing and genomic analysis has facilitated the discovery of new causes of inherited platelet disorders. Studies of these disorders and their respective mouse models have been central to understanding their biology, and also in revealing new aspects of platelet function and production. This review covers recent contributions to the identification of genes, proteins and variants associated with inherited platelet defects, and highlights how these studies have provided insights into platelet development and function.

Recent findings
Novel genes recently implicated in human platelet dysfunction include the galactose metabolism enzyme UDP-galactose-4-epimerase in macrothrombocytopenia, and erythropoietin-producing hepatoma-amplified sequence receptor transmembrane tyrosine kinase EPHB2 in a severe bleeding disorder with deficiencies in platelet agonist response and granule secretion. Recent studies of disease-associated variants established or clarified roles in platelet function and/or production for the membrane receptor G6b-B, the FYN-binding protein FYB1/ADAP, the RAS guanyl-releasing protein RASGRP2/CalDAG-GEFI and the receptor-like protein tyrosine phosphatase PTPRJ/CD148. Studies of genes associated with platelet disorders advanced understanding of the cellular roles of neurobeachin-like 2, as well as several genes influenced by the transcription regulator RUNT-related transcription factor 1 (RUNX1), including NOTCH4.

Summary
The molecular bases of many hereditary platelet disorders have been elucidated by the application of recent advances in cell imaging and manipulation, genomics and protein function analysis. These techniques have also aided the detection of new disorders, and enabled studies of disease-associated genes and variants to enhance understanding of platelet development and function.
Developing a Process for Criteria-Led Discharge
Authors: Lees-Deutsch Liz , Jackson Julia , Balaji Ariyur , Topping Annie 
Published: July 2019

Background:
Criteria-led discharge (CLD) is an approach for maximizing bed capacity by expediting patient discharge.

Problem:
In acute medicine settings, patients commonly have multiple medical problems, which render single care pathway and clinical protocols of limited use. CLD offers potential, but little evidence exists about how to best implement it in these contexts.

Approach:
Retrospective case note analysis generated characteristics from patients' discharge plans to design a criterion-based framework to aid patient selection for CLD. These criteria were hypothetically tested on patient case notes (n = 50).

Outcomes:
CLD was identified as suitable (n = 27) and unsuitable (n = 23) from 50 case notes. Interrater agreement was 86% between 3 reviewers.

Conclusions:
This review has provided greater understanding of the complexity of discharge in acute medicine settings. Implementing CLD to optimize timeliness of patient discharge might offer a solution for selected patients.
Implementing and Evaluating the Impact of a Nurse-Led Oral Care Initiative
Authors: Castillo Dora H. , Smith Daniel J. , Rosenfeld Peri 
Published: July 2019

Background:
Nursing interventions in oral hygiene have been shown to be important for health promotion and illness prevention. This medical center advanced a registered nurse (RN)-led oral health initiative to introduce and standardize oral care practices.

Problem:
To examine the impact of the oral health initiative, we conducted an evaluation of documentation trends among RNs and the effect of the initiative on patients' oral health during hospitalization.

Approach:
We used a single-group pretest-posttest design and drew a sample of all inpatients who were admitted to the medical center from October 1 through December 31, 2017.

Outcomes:
Of the 13 303 patients admitted, the empirical evidence demonstrates 99.5% compliance in documentation at admission and discharge. Among 13 237 patients, there was improvement in patients' oral health during hospitalization (−0.03, P < .001), especially those initially assessed with moderate or severe dysfunction.

Conclusions:
The oral health initiative standardized assessment and care practices that have improved outcomes in patients' oral hygiene.
Methods and Processes Used to Collect Pressure Injury Risk and Prevention Measures in the National Database of Nursing Quality Indicators® (NDNQI®)
Authors: Waugh Shirley Moore , Bergquist-Beringer Sandra 
Published: July 2019

Background:
Previous research found that reliability estimates for chart-extracted quality of care data vary.

Purpose:
The purpose was to examine methods and processes used to gather data on the National Database of Nursing Quality Indicators (NDNQI) pressure injury (PI) risk and prevention measures to identify factors that may influence their reliability.

Methods:
Study participants (N = 120) from 36 hospitals completed a 35-item online survey. Included were the NDNQI PI Survey Team member with the most experience and/or skill in patient record review from each hospital (n = 36) and 84 other NDNQI PI Survey Team members.

Results:
In general, participants followed NDNQI PI data collection guidelines. However, deviations were noted such as 60 (50%) participants collected PI data on units where they work, and 92 (76.7%) determined whether moisture management was performed by direct observation of patients rather than chart documentation.

Conclusions:
Findings provide insight on how to improve the reliability of hospital-acquired PI risk and prevention measures that includes clarification of the data collection guidelines.
The Association Between Child Abuse and Emotional and Behavioral Problems in Chinese School-Aged Boys With Attention Deficit Hyperactivity Disorder
Authors: Zou Shaohong , Yu Wenwen , Liang Sixiang , Ma Xiaojuan , Li Dazhi , Bian Yanhui , Zhang Yong 
Published: July 2019

Abstract
The aim of our study was to investigate the relationship between child abuse and emotional and behavioral problems in Chinese school-aged boys with attention deficit hyperactivity disorder (ADHD). Forty-eight school-aged boys with ADHD and 77 male healthy controls completed the final assessments that included the Child Behavior Checklist, the Barratt Impulsiveness Scale Version 11, the Screen for Child Anxiety Related Disorders, the Depression Self-Rating Scale for Children, and the Childhood Trauma Questionnaire, Short Form. Our findings showed that child abuse could associate with the behavioral problems in ADHD. Regression analysis further showed that child abuse (especially emotional abuse and physical abuse), adverse living conditions, and school anxiety significantly could be contributors to behavioral problems in boys with ADHD. Our study indicated that child abuse may be associated with the behavioral problems in Chinese school-aged boys with ADHD.
Positive Predictive Values of Lumbar Spine Magnetic Resonance Imaging Findings for Provocative Discography
Authors: Chelala Lydia , Trent Graham , Waldrop Greer , Dagher Azar P. , Reinig James W. 
Published: July 2019

Purpose
The purpose of this study was to calculate the positive predictive value (PPV) of lumbar spine magnetic resonance imaging (MRI) findings for a painful disc using provocative discography.

Materials and Methods
Lumbar spine discography records and prediscography MRIs of 736 patients (2457 discs) who underwent discography for diagnostic purposes from 2003 to 2007 were retrospectively reviewed in an Institutional Review Board–exempt and Health Insurance Portability and Accountability Act–compliant protocol. Each level was identified as having high-intensity zone (HIZ) disc, disc protrusion, disc extrusion, or combination (any herniation type), disc bulge, disc degeneration, and spondylolisthesis. Statistical analysis used a 2 × 2 contingency table of significant discography results for each of the MRI variables to calculate P value and PPV with a confidence interval from a binomial distribution.

Results
An HIZ disc has a PPV of 0.71 (0.65–0.76, P = 4.31E − 44) for a provocative discography. A disc protrusion has a PPV of 0.79 (0.73–0.83, P = 2.68E − 53). A disc extrusion has a PPV of 0.93 (0.79–0.98, P = 1.34E − 14), a bulge of 0.43 (0.37–0.48, P = 0.002), and a degenerative disc of 0.32 (0.28–0.35, P = 0.08), and spondylolisthesis has a PPV of 0.67 (0.59–0.73, P = 1.70E − 20). A herniation of either type (extrusion or protrusion) has a PPV of 0.80 (0.75–0.84, P = 5.86E − 69).

Conclusions
Disc herniations and HIZ discs have high predictive value in identifying a pain generator. An extruded disc herniation has the highest PPV for discogenic pain.
Nivolumab-Induced Pneumonitis in Patient With Metastatic Melanoma Showing Complete Remission on 18F-FDG PET/CT
Authors: Razzouk-Cadet Micheline , Picard Alexandra , Grangeon-Chapon Caroline , Lacour Jean-Philippe , Montaudié Henri 
Published: July 2019

Abstract
A 49-year-old patient with metastatic melanoma was treated with nivolumab (Opdivo). An early 18F-FDG PET/CT after 2 cycles showed a progressive metabolic disease. A 4-month optimal follow-up 18F-FDG PET/CT showed a complete metabolic response. The treatment was stopped after 22 cycles because of immunotherapy-related pneumonitis. After discontinuation of treatment, PET/CT examinations demonstrated a metabolic complete remission during 2 years. The metabolic pattern on early PET was suggestive of pseudoprogression, which is a rare phenomenon reflecting an activation of inflammatory cells within the tumor microenvironment causing lesions to increase in size and to accumulate FDG until a sufficient immune response is developed.
Incidental Finding of Acute Lymphocytic Leukemia in a Prostate-Specific Membrane Antigen PET/CT
Authors: Acksteiner Christian , Sounness Brett 
Published: July 2019

Abstract
PSMA PET/CT is known to show uptake in various benign and malignant processes. The following PSMA PET/CT was performed for prostate carcinoma staging (Gleason 3 + 4 left apex; PSA 5.8). It shows incidental diffuse PSMA marrow uptake, not typical for prostate metastatic disease. No treatment had been commenced at the time of the scan. Serology and bone marrow biopsy showed B-cell acute lymphocytic leukemia. Focal PSMA uptake in the right ischium was correlated with a T1 hypointense lesion on a previous MRI and was convincing for a skeletal metastasis. Alternative diagnoses in diffuse skeletal PSMA uptake need therefore to be considered.
18F-Fluorocholine PET/CT in the Prediction of Molecular Subtypes and Prognosis for Gliomas
Authors: García Vicente Ana María , Pérez-Beteta Julian , Amo-Salas Mariano , Pena Pardo Francisco José , Villena Martín Maikal , Sandoval Valencia Hernán , Mollejo Villanueva Manuela , Barbella Rosa , Klein Zampaña Christoph José , Borrás Moreno José María , Soriano Castrejón Ángel María , Pérez-García Víctor Manuel 
Published: July 2019

Aim
To study the association of metabolic features of 18F-fluorocholine in gliomas with histopathological and molecular parameters, progression-free survival (PFS) and overall survival (OS).

Methods
Prospective multicenter and nonrandomized study (Functional and Metabolic Glioma Analysis). Patients underwent a basal 18F-fluorocholine PET/CT and were included after histological confirmation of glioma. Histological and molecular profile was assessed: grade, Ki-67, isocitrate dehydrogenase status and 1p/19q codeletion. Patients underwent standard treatment after surgery or biopsy, depending on their clinical situation. Overall survival and PFS were obtained after follow-up. After tumor segmentation of PET images, SUV and volume-based variables, sphericity, surface, coefficient of variation, and multilesionality were obtained. Relations of metabolic variables with histological, molecular profile and prognosis were evaluated using Pearson χ2 and t test. Receiver operator caracteristic curves were used to obtain the cutoff of PET variables. Survival analysis was performed using Kaplan-Meier and Cox regression analysis.

Results
Forty-five patients were assessed; 38 were diagnosed as having high-grade gliomas. Significant differences of SUV-based variables with isocitrate dehydrogenase status, tumor grade, and Ki-67 were found. Tumor grade, Ki-67, SUVmax, and SUVmean were related to progression. Kaplan-Meier analysis revealed significant associations of SUVmax, SUVmean, and multilesionaly with OS and PFS. SUVmean, sphericity, and multilesionality were independent predictors of OS and PFS in Cox regression analysis.

Conclusions
Metabolic information obtained from 18F-fluorocholine PET of patients with glioma may be useful in the prediction of tumor biology and patient prognosis.
68Ga-DOTATATE Uptake in Pancreatic Metastasis of Renal Cell Carcinoma Mimicking Pancreatic Neuroendocrine Tumor
Authors: Soydal Cigdem , Nak Demet , Araz Mine , Demirkazik Ahmet , Kucuk Nuriye Ozlem 
Published: July 2019

Abstract
A 61-year-old man, with a history of prior clear cell renal cell carcinoma in remission, was referred to 68Ga-DOTATATE PET/CT for the further evaluation of pancreatic tail mass. 68Ga-DOTATATE PET/CT showed pathologically intense uptake on the pancreatic mass; subsequent biopsy of the pancreatic mass confirmed the diagnosis of clear cell renal cell carcinoma metastasis. 68Ga-DOTATATE uptake is not specific for neuroendocrine tumors. In the presence of prior malignancy, it should be kept in mind that malignancies apart from neuroendocrine tumors express somatostatin receptors, and they can show 68Ga-DOTATATE uptake.
Brain 123I-FP-CIT SPECT of a Holmes Tremor Due to Midbrain Pilocytic Astrocytoma
Authors: Louarn Nicolas , Kharroubi Dris , Fourquet Aloÿse , Vidailhet Marie , Kas Aurélie 
Published: July 2019

Abstract
A 24-year-old woman with an unresectable right mesencephalic pilocytic astrocytoma was treated with stereotaxic radiation therapy. Three months after a radiation therapy–induced bleeding, she presented a severe disabling low frequency rest and kinetic tremor involving the left upper limb, associated with dystonia, and a Holmes tremor was suspected. Thereby, we performed a 123I-FP-CIT SPECT (DATSCAN) that revealed a normal distribution of radiotracer over the left striatum, whereas no binding was seen in the right caudate and putamen. This pattern was consistent with a right severe nigrostriatal dopaminergic denervation due to an ipsilateral red nucleus injury.
Heat-Damaged Red Blood Cell Scintigraphy in Helping Interpretation of 68Ga-DOTATATE PET/CT
Authors: Wen Zhe , Edwards Kevin W. , States Lisa J. , Zhuang Hongming 
Published: July 2019

Abstract

68Ga-DOTATATE PET/CT was performed to determine the cause of endogenous Cushing syndrome in a 10-year-old boy whose MRI studies did not reveal pituitary or adrenal gland abnormality. The PET/CT images demonstrated an intense activity in a small soft tissue nodule in the left upper abdomen where splenules are commonly located. Heat-damaged 99mTc-labeled red blood cell imaging showed that this soft tissue nodule did not have increased red blood cell activity, which indicated that this lesion was a true somatostatin receptor–rich lesion. The pathology result following surgical resection of the lesion confirmed adrenocorticotropic hormone–producing neuroendocrine tumor.
Incidental Finding of Benign Trichilemmal Cysts on 99mTc-Octreotide Scan
Authors: Neshandar Asli Isa , Norouzi Ghazal 
Published: July 2019

Abstract
A 63-year-old woman with neuroendocrine carcinoma of the colon was referred to our department for staging with 99mTc-octreotide scan. Two focal, highly intense, superficial lesions were detected in patient's scalp and paralumbar region, medial to the right kidney. Pathology correlation was recommended, revealing them both to be benign trichilemmal cysts. This unexpected finding strengthens the hypothesis of Merkel cell carcinoma and trichilemmal cysts originating from pluripotent stem cells of adnexal epithelium, making a neuroendocrine differentiation for the latter plausible.
Virtual Surgical Planning and One-Stage Treatment of Active Hemimandibular Hyperplasia
Authors: Diniz Jiordanne Araújo , Siqueira Allancardi dos Santos , Torres Luiz Henrique Soares , Faro Tatiane Fonseca , Rodrigues Ewerton Daniel Rocha , Laureano Filho José Rodrigues 
Published: July 2019

Abstract
Hemimandibular hyperplasia was first described in 1836 by Adams as a disorder that causes condylar hyperplasia, deforming facial asymmetry and has an unknown etiology. The objective of this study was to report a patient with surgical correction through orthognathic surgery and high condilectomy for the treatment of hemimandibular hyperplasia. The patient complained of pain and cracking in the right temporomandibular joint region and was dissatisfied with the aesthetic appearance of the face. Virtual planning was done for bimaxillary orthognathic surgery and preparation of prototyped surgical guides. Stereolithographic models were used for the preparation of the acrylic guides of the osteotomies for the high condilectomy and the contour of the mandibular base. Orthognathic surgery resulted in the maxillary repositioning with correction of the inclination of the occlusal plane, reduction of the height of the ramus and right mandibular body and class I dental attachment. Mandibular contour osteotomy was performed with acrylic guide in the basilar. The condilectomy was performed by endaural access. In 2-year follow-up, there are no signs of recurrence.
Effect of Alveolar Bone Grafting on Health Quality in Patients With Cleft Lip and Palate
Authors: Sancak Kevser , Eren Hakan , Altug Ayse Tuba , Tezuner Aysegul Mine 
Published: July 2019

Introduction:
This study aimed to explore the effect of alveolar bone grafting on the clinical outcomes, health quality, and satisfaction in patients with cleft lip and palate.

Materials and Methods:
Questionnaire review study was done to patients who underwent secondary alveolar bone grafting retrospectively. This study included 28 patients who underwent secondary alveolar bone grafting by harvesting graft from the anterior iliac crest, excluding one, in Oral and Maxillofacial Department, Faculty of Dentistry, Ankara University, Turkey, during the period from January 2012 to March 2016. All patients were operated using the same technique and by the same surgical team. Patients were interviewed to fill Short-Form Health Survey (SF-12) and Postsurgical Patient Satisfaction Questionnaire (PSPSQ) 6 months postoperatively. The questionnaires were used to assess the relationship between health quality and patient satisfaction. Also, grafted sites were evaluated with respect to fistula, presence of cleft palate.

Results:
The sample consisted of 28 patients (19 females and 9 males), including 13 with bilateral clefts and 15 with unilateral clefts. The mean Physical Component Summary (PCS) and Mental Component Summary (MCS) of SF-12 scores were 54.5718 and 44.6436, respectively. The mean PSPSQ score was 36.7368. PCS scores were found to be significantly correlated with the PSPSQ scores (P ≤0.05). No correlation was found between MCS and PSPSQ scores (P >0.05). A precise and good planned surgery resulted in good satisfaction among patients with cleft lip and palate who underwent alveolar bone grafting. The patient satisfaction was correlated with the success of the operation.
Dietetic assessment and intervention in lung cancer
Authors: Phillips Iain , Hug Adele , Allan Lindsey , Ezhil Veni 
Published: July 2019

Purpose of review
Systemic therapy for lung cancer is increasing in intensity and duration. European nutrition guidelines suggest screening for weight loss and malnutrition, however acknowledges there is a lack of evidence. We discuss current data round this issue and identify opportunities for further research.

Recent findings
International guidelines now exist to aid the definition of weight loss in cancer, including cachexia, sarcopenia and malnutrition. These allow consistent definition of overlapping, but distinct clinical syndromes. Nutritional status can be assessed in a range of ways including questionnaires, functional assessments, blood markers, physical activity, weight and BMI. Weight loss is commonly associated with a proinflammatory state. Future treatment is likely to be a combination of dietetic support and pharmacological treatment of cachexia.

Summary
There is a paucity of data on dietetic intervention. It is potentially quick, inexpensive and patient specific, using a holistic approach to aid patients who are malnourished or at risk of malnutrition. Lung cancer-related weight loss is common, further strategies are needed to effectively assess and intervene. Dietetic intervention has the potential to improve patients’ quality of life and outcomes.