bluuebunny/crossref_metadata_2025_split huggingface dataset:
Multilevel regulation of RUVBL2 expression predicts poor prognosis in hepatocellular carcinoma
Authors: Yan Tao , Liu Fang , Gao Jiajia , Lu Haizhen , Cai Jianqiang , Zhao Xiaohang , Sun Yulin 
Published: September 2019

Abstract

Background
Hepatocellular carcinoma (HCC) is the second-most lethal cancer worldwide with a complex pathogenesis. RuvB-like 2 (RUVBL2) was previously found to contribute to hepatocarcinogenesis. However, its expression, regulation and clinical significance have not been systematically evaluated in a large number of clinical samples.

Methods
Here, we performed a comprehensive analysis of RUVBL2 based on multiple datasets from 371 liver cancer patients of The Cancer Genome Atlas (TCGA) and on immunohistochemical staining in 153 subjects. In addition, the aberrant signaling pathways caused by RUVBL2 overexpression were investigated.

Results
We demonstrated that promoter hypomethylation, copy number gain, MYC amplification and CTNNB1 mutation were all responsible for RUVBL2 overexpression in HCC. High levels of RUVBL2 mRNA were associated with shorter recurrence-free survival time (RFS) but not overall survival time (OS). Furthermore, RUVBL2 protein was overexpressed in the nucleus and cytoplasm of HCC samples. Univariate and multivariate survival analyses showed that strong nuclear and cytoplasmic staining of RUVBL2 independently predicted worse OS and RFS with a 2.03-fold and a 1.71-fold increase in the hazard ratio, respectively. High levels of RUVBL2 promoted carcinogenesis through the heat shock protein 90 (HSP90)-Cell Division Cycle 37 (CDC37), AKT serine/threonine kinase (AKT) and mitogen-activated protein kinase (ERK/MAPK) pathways.

Conclusion
The deregulation of RUVBL2 in HCC is influenced at the genomic, epigenetic and transcriptional levels. Our findings highlight the potential roles of RUVBL2 as a promising prognostic marker as well as a therapeutic target for HCC.
Generalized k-fractional integral inequalities associated with $(\alpha ,m)$-convex functions
Authors: Kang S. M. , Farid G. , Waseem M. , Ullah S. , Nazeer W. , Mehmood S. 
Published: September 2019

Abstract
This research investigates bounds of the sum of left-sided and right-sided fractional integrals in a compact form. These bounds are established by using $(\alpha ,m)$
(
α
,
m
)
-convex functions. The results of this paper also have connection with some known and already published results (Dragomir and Agarwal in Appl. Math. Lett. 11(5):91–95, 1998; Farid in J. Anal. 2018, https://doi.org/10.1007/s41478-0079-4; Farid et al. in Mathematics 2018(6):248, 2018). Moreover, the investigated results are applied to the end points as well as the mid point of the domain and some interesting consequences have been obtained.
Enabling architecture based Co-Simulation of complex Smart Grid applications
Authors: Binder Christoph , Fischinger Michael , Altenhuber Lukas , Draxler Dieter , Lastro Goran , Neureiter Christian 
Published: September 2019

AbstractThe integration of decentralized prosumers into current energy systems leads to continuously increasing complexity in today‘s popular term of the Smart Grid. Since conventional engineering methods reach their limits when dealing with the challenges in developing such systems, model-driven approaches like Domain Specific Systems Engineering (DSSE) gain significant importance. Contributing to the agile development of such a System of Systems (SoS), the application of the DSSE approach is furthermore supported by the introduction of the Smart Grid Architecture Model (SGAM) and Mosaik. However, with both concepts being individual methodologies, their interconnection is missing specifications. Therefore, this paper proposes the development of an interface between architecting and simulating a complex Smart Grid. To achieve this, the concepts of SGAM and Mosaik are analyzed in the first place in order to set up a suitable architectural model of an energy system and the corresponding simulation scenario. Subsequently, the applicability of the present approach is demonstrated by utilizing an excerpt of a real-world case study, the charging behavior of an Electric Vehicle (EV).
Forecasting cross-border power transmission capacities in Central Western Europe using artificial neural networks
Authors: Abdel-Khalek Hazem , Schäfer Mirko , Vásquez Raquel , Unnewehr Jan Frederick , Weidlich Anke 
Published: September 2019

AbstractFlow-based Market Coupling (FBMC) provides welfare gains from cross-border electricity trading by efficiently providing coupling capacity between bidding zones. In the coupled markets of Central Western Europe, common regulations define the FBMC methods, but transmission system operators keep some degrees of freedom in parts of the capacity calculation. Besides, many influencing factors define the flow-based capacity domain, making it difficult to fundamentally model the capacity calculation and to derive reliable forecasts from it. In light of this challenge, the given contribution reports findings from the attempt to model the capacity domain in FBMC by applying Artificial Neural Networks (ANN). As target values, the Maximum Bilateral Exchanges (MAXBEX) have been chosen. Only publicly available data has been used as inputs to make the approach reproducible for any market participant. It is observed that the forecast derived from the ANN yields similar results to a simple carry-forward method for a one-hour forecast, whereas for a longer-term forecast, up to twelve hours ahead, the network outperforms this trivial approach. Nevertheless, the overall low accuracy of the prediction strongly suggests that a more detailed understanding of the structure and evolution of the flow-based capacity domain and its relation to the underlying market and infrastructure characteristics is needed to allow market participants to derive robust forecasts of FMBC parameters.
UTS2B Defines a Novel Enteroendocrine Cell Population and Regulates GLP-1 Secretion Through SSTR5 in Male Mice
Authors: Tang Cong , Ksiazek Iwona , Siccardi Noemie , Gapp Berangere , Weber Delphine , Wirsching Johann , Beck Valerie , Reist Matthias , Gaudet Laurent , Stuber Nathalie , Surber Sabrina Silvia , Mao Xiaohong , Nicholson Thomas B , Carbone Walter , Beibel Martin , Roma Guglielmo , Gubser Keller Caroline , Bassilana Frederic 
Published: September 2019

AbstractThe gut-pancreas axis plays a key role in the regulation of glucose homeostasis and may be therapeutically exploited to treat not only type 2 diabetes but also hypoglycemia and hyperinsulinemia. We identify a novel enteroendocrine cell type expressing the peptide hormone urotensin 2B (UTS2B). UTS2B inhibits glucagon-like peptide-1 (GLP-1) secretion in mouse intestinal crypts and organoids, not by signaling through its cognate receptor UTS2R but through the activation of the somatostatin receptor (SSTR) 5. Circulating UTS2B concentrations in mice are physiologically regulated during starvation, further linking this peptide hormone to metabolism. Furthermore, administration of UTS2B to starved mice demonstrates that it is capable of regulating blood glucose and plasma concentrations of GLP-1 and insulin in vivo. Altogether, our results identify a novel cellular source of UTS2B in the gut, which acts in a paracrine manner to regulate GLP-1 secretion through SSTR5. These findings uncover a fine-tuning mechanism mediated by a ligand-receptor pair in the regulation of gut hormone secretion, which can potentially be exploited to correct metabolic unbalance caused by overactivation of the gut-pancreas axis.
Identification of matrix physicochemical properties required for renal epithelial cell tubulogenesis by using synthetic hydrogels
Authors: Cruz-Acuña Ricardo , Mulero-Russe Adriana , Clark Amy Y. , Zent Roy , García Andrés J. 
Published: September 2019

ABSTRACT
Synthetic hydrogels with controlled physicochemical matrix properties serve as powerful in vitro tools to dissect cell–extracellular matrix (ECM) interactions that regulate epithelial morphogenesis in 3D microenvironments. In addition, these fully defined matrices overcome the lot-to-lot variability of naturally derived materials and have provided insights into the formation of rudimentary epithelial organs. Therefore, we engineered a fully defined synthetic hydrogel with independent control over proteolytic degradation, mechanical properties, and adhesive ligand type and density to study the impact of ECM properties on epithelial tubulogenesis for inner medullary collecting duct (IMCD) cells. Protease sensitivity of the synthetic material for membrane-type matrix metalloproteinase-1 (MT1-MMP, also known as MMP14) was required for tubulogenesis. Additionally, a defined range of matrix elasticity and presentation of RGD adhesive peptide at a threshold level of 2 mM ligand density were required for epithelial tubulogenesis. Finally, we demonstrated that the engineered hydrogel supported organization of epithelial tubules with a lumen and secreted laminin. This synthetic hydrogel serves as a platform that supports epithelial tubular morphogenetic programs and can be tuned to identify ECM biophysical and biochemical properties required for epithelial tubulogenesis.
Reversible solidification of fission yeast cytoplasm after prolonged nutrient starvation
Authors: Heimlicher Maria B. , Bächler Mirjam , Liu Minghua , Ibeneche-Nnewihe Chieze , Florin Ernst-Ludwig , Hoenger Andreas , Brunner Damian 
Published: September 2019

ABSTRACT
Cells depend on a highly ordered organisation of their content and must develop strategies to maintain the anisotropic distribution of organelles during periods of nutrient shortage. One of these strategies is to solidify the cytoplasm, which was observed in bacteria and yeast cells with acutely interrupted energy production. Here, we describe a different type of cytoplasm solidification fission yeast cells switch to, after having run out of nutrients during multiple days in culture. It provides the most profound reversible cytoplasmic solidification of yeast cells described to date. Our data exclude the previously proposed mechanisms for cytoplasm solidification in yeasts and suggest a mechanism that immobilises cellular components in a size-dependent manner. We provide experimental evidence that, in addition to time, cells use intrinsic nutrients and energy sources to reach this state. Such cytoplasmic solidification may provide a robust means to protect cellular architecture in dormant cells.
Discovery of aspirin-triggered eicosanoid-like mediators in a Drosophila metainflammation blood tumor model
Authors: Panettieri Silvio , Paddibhatla Indira , Chou Jennifer , Rajwani Roma , Moore Rebecca S. , Goncharuk Tamara , John George , Govind Shubha 
Published: September 2019

ABSTRACT
Epidemiologic studies have linked the use of aspirin to a decline in chronic inflammation that underlies many human diseases, including some cancers. Aspirin reduces the levels of cyclooxygenase-mediated pro-inflammatory prostaglandins, promotes the production of pro-resolution molecules, and triggers the production of anti-inflammatory electrophilic mono-oxygenated (EFOX) lipid mediators. We investigated the effects of aspirin in fruit fly models of chronic inflammation. Ectopic Toll/NF-κB and JAK/STAT signaling in mutant D. melanogaster results in overproliferation of hematopoietic blood progenitors resulting in the formation of granuloma-like tumors. Ectopic JAK-STAT signaling also leads to metabolic inflammation. We report that aspirin-treated mutant flies experience reduction in metabolic inflammation, mitosis, ectopic immune signaling, and macrophage infiltration. Moreover, these flies synthesize 13-HODE, and aspirin triggers 13-oxoODE (13-EFOX-L2) production. Providing the precursor of 13-HODE, linoleic acid, or performing targeted knockdown of the transcription factor STAT in inflammatory blood cells, boosts 13-EFOX-L2 levels while decreasing metabolic inflammation. Thus, hematopoietic cells regulate metabolic inflammation in flies, and their effects can be reversed by pharmaceutical or dietary intervention, suggesting deep phylogenetic conservation in the ability of animals to resolve inflammation and repair tissue damage. These findings can help identify novel treatment targets in humans.
Selection and application of coils in temporomandibular joint MRI
Authors: Sun Qi , Dong Min-jun , Tao Xiao-feng , Jiang Meng-da , Yang Chi 
Published: September 2019

Objective: To compare and evaluate the signal-to-noise ratio (SNR) and the contrast-to-noise ratio (CNR) values between a 15-channel phased array head coil and 6-channel dS Flex M surface coil in the MRI of temporomandibular joint. Methods: 300 patients were randomly assigned to two groups: 150 patients were examined by using a 15-channel phased array head coil and the other 150 patients were scanned by using a 6-channel dS Flex M surface coil. All of the data were set in the same 6 regions of interest including the temporal lobe, condyle neck, lateral pterygoid muscle, parotid gland, the adipose area and an area of the background noise）. SNR and CNR values were measured respectively. Results: The numerical variation law of SNR and CNR values measured in regionsof interest of each group was similar, although different coils were used. There were statistically significant differences of SNR values in all of the oblique sagittal (OSag) proton density-weighted imaging, the part of OSag T 2 weighted image (T 2WI) except for SNR4 and SNR5. and oblique coronal (OCor) T 2WI sequence except for SNR2. On the contrary, SNR4 and SNR5 values in the OCor T 2WI and SNR5 values in OSag T 2WI sequences by using the surface coil were higher than those by using the head coil. There were no statistically significant intergroup differences of CNR values in OSag proton density-weighted imaging sequence except CNR1 and in OSag T 2WI sequence except CNR5. But, statistically significant differences of all the values in the OCor T 2WI sequence except for CNR1 were observed. Conclusion: Both the phased array head coil and dS Flex M surface coil can be used for temporomandibular joint MRI.
Solitary plasmacytoma of maxillofacial bones: correlation of CT features with pathological findings
Authors: Liu Yu , Li Kaicheng 
Published: September 2019

Objective: To explore the CT features of solitary plasmacytoma (SP) of maxillofacial bones and correlation with pathological findings. Methods and materials: We retrospectively reviewed the clinical, CT and pathological features of SP in the maxillofacial bones. 16 patients with clinically and histologically proven SP of maxillofacial bones were involved. They were aged from 27 to 79 years old (median 55.5 years old), and included 12 males and 4 females (males vs females: 3:1). All patients performed CT examination, in whom 13 patients underwent enhanced scanning and 3 plain scanning. The CT images were assessed for lesion location, size (maximum diameter), shape (round, oval and irregular), boundary (defined and illdefined), bone changes (bone destruction, residual bone, sclerotic margin and periosteal reaction), density of soft tissue mass and enhancement manifestations, and invasion of adjacent structures. Results: 13 patients suffered from SP in the mandible, 2 in the zygoma, and 1 in the maxilla and hard palate. The maximum diameter of lesions ranged from 2.4 to 8.2 cm (mean 3.93 ± 1.435 cm). Most lesions were founded as a solitary osteolytic lesions (15/16, 93.75%) with round or ovoid shape (13/16, 81.25%), smooth margin (16/16, 100%) and defined boundary (16/16, 100%) in bone marrow. They destroyed bone cortex (15/16, 93.75%) and had residual bone (10/16, 62.5%), without sclerosis margin (15/16, 93.75%) and periosteal reaction (14/16, 87.5%). They easily formed soft tissue masses (16/16, 100%) and invade adjacent anatomical structures (15/16, 93.75%). The density of lesions was usually uniform (12/16, 75%) with strong enhancement. There was a significant difference in CT values between plain and enhanced scanning [50.75 ± 9.140 Hounfield unit (HU) vs 101.0 ± 28.830 HU; p < 0.001), with the mean difference of CT values 50.25 HU. Conclusions: SP is predominant in the mandible of elderly male patients. A solitary, round or ovoid, well-defined, osteolytic, invasive mass in bone marrow, which destroys bone cortex, has residual bone, no sclerosis margin and periosteal reaction, and shows strong enhancement, is suggestive of this diagnosis.
Discovery of novel plasma biomarker ratios to discriminate traumatic brain injury
Authors: Chen Michelle , Soosaipillai Antoninus , Fraser Douglas D. , Diamandis Eleftherios P. 
Published: September 2019

Background: Traumatic brain injury (TBI) is a major cause of death and disability. Despite increased awareness, reliable biomarkers are urgently needed to aid in all forms of traumatic brain injury diagnosis and prognosis. Methods: Here, we aim to assess the diagnostic utility of known and novel TBI biomarkers in a pilot patient cohort of severe TBI (sTBI) patients and healthy controls. We analyzed concentrations of S100 calcium binding protein B (S100B), neuron specific enolase (NSE), human kallikrein 6 (hK6) and prostaglandin D2 synthase (PGDS) using ELISA immunoassays. Results: Plasma levels of hK6 and PGDS were significantly lower in sTBI compared with controls, while S100B and NSE were significantly higher. Furthermore, we show that ratios of NSE and S100B with hK6 and PGDS may be able to determine the presence of sTBI better than single markers alone. Conclusions: The findings presented here represent a starting point for future validation, where biomarker ratios can be tested in independent TBI cohorts.
Interobserver reliability of Diméglio and Pirani score and their subcomponents in the evaluation of idiopathic clubfoot in a clinical setting: A need for improved scoring systems
Authors: Bettuzzi C. , Abati C. N. , Salvatori G. , Zanardi A. , Lampasi M. 
Published: September 2019

Purpose Diméglio (DimS) and Pirani (PirS) scores are the most commonly used scoring systems for evaluation of clubfoot, with many centres performing both. Interobserver reliability of their global score has been rated high in a few studies, but agreement of their subcomponents has been poorly investigated. The aim of the study was to assess interrater reliability of global scores and of items in a clinical setting and to analyse overlapping features of the two scores. Methods Fifty-six consecutive idiopathic clubfeet undergoing correction using the Ponseti method were independently evaluated at each casting session by two trained paediatric orthopaedic surgeons using both scores. Interobserver reliability of collected data was analysed; a kappa coefficient > 0.60 was considered adequate. Results For DimS and PirS, the Pearson correlation coefficients were 0.87 and 0.91 (p < .0001) respectively, and kappa coefficients were 0.23 and 0.31. Among subcomponents, kappa values were rated > 0.60 only for equinus and curvature of lateral border in PirS; muscular abnormality in DimS was rated 0.74 but a high prevalence index (0.94) indicated influence of scarce prevalence of this feature. All other items showed k < 0.60 and were considered to be improved. For overlapping features: posterior and medial crease showed similar agreement in the two systems, items describing equinus and midfoot adduction were much more reliable in PirS than in DimS. Conclusions In a clinical setting, despite a high correlation of evaluations for total scores, the interobserver agreement of DimS and PirS was not adequate and only a few items were substantially reliable. Simultaneous use of two scores seemed redundant and some overlapping features showed different reliability according to criterion or scale used. Future scoring systems should improve these limitations. Level of Evidence Level I – Diagnostic studies
Falas entrecruzadas, o viés feminista na produção midiática de Clarice Lispector
Authors: Nunes Aparecida Maria 
Published: September 2019

O artigo analisa a produção acadêmica de Clarice Lispector publicada na revista A Época de 1941, bem como as narrativas que compõem a página “Entre Mulheres”, do tabloide Comício de 1952. É possível reconhecer nesses textos a preocupação da escritora com os papéis femininos e a influência de Simone de Beauvoir em seu pensamento, ao divulgar, de forma velada, trechos que traduz de Le Deuxième Sexe.
PALAVRAS-CHAVE: Clarice Lispector. Feminismo. A Época. Comício. Simone de Beauvoir.

ABSTRACT
The article analyzes the academic production of Clarice Lispector published in the magazine A Época of 1941, as well as the narratives that compose the page "Entre Mulheres", of the tabloid Comício of 1952. It is possible to recognize in these texts the concern of the writer with the feminine roles and the influence of Simone de Beauvoir in her thought, by disseminating, in a veiling way, excerpts that translates from Le Deuxième Sexe.
KEYWORDS: Clarice Lispector. Feminism. A Época. Comício. Simone de Beauvoir.
Automated design process for hybrid regression modeling with a one-class SVM
Authors: Böhland Moritz , Doneit Wolfgang , Gröll Lutz , Mikut Ralf , Reischl Markus 
Published: September 2019

Abstract
The accuracy of many regression models suffers from inhomogeneous data coverage. Models loose accuracy because they are unable to locally adapt the model complexity. This article develops and evaluates an automated design process for the generation of hybrid regression models from arbitrary submodels. For the first time, these submodels are weighted by a One-Class Support Vector Machine, taking local data coverage into account. Compared to reference regression models, the newly developed hybrid models achieve significant better results in nine out of ten benchmark datasets. To enable straightforward usage in data science, an implementation is integrated in the open source MATLAB toolbox SciXMiner.
Fahrstreifenerkennung mit Deep Learning für automatisierte Fahrfunktionen
Authors: Schmidt Manuel , Krüger Martin , Lienke Christian , Oeljeklaus Malte , Nattermann Till , Mohamed Manoj , Hoffmann Frank , Bertram Torsten 
Published: September 2019

Zusammenfassung
Der vorliegende Beitrag untersucht die Erkennung benachbarter Fahrstreifen auf Grundlage von Kamerabildern. Hierbei wird sowohl die Anzahl befahrbarer Fahrstreifen als auch deren Verlauf innerhalb eines festgelegten Bereichs vor dem Fahrzeug bildbasiert geschätzt. Die Erkennung erfolgt durch Convolutional Neural Networks. Der Beitrag bewertet die Güte der Schätzung und Genauigkeit der Fahrstreifenerkennung. Zur Interpretation der Entscheidungen werden die durch das neuronale Netz gelernten Merkmale und Zwischenrepräsentationen visualisiert.
Fuzzy tissue detection for real-time focal control in corneal confocal microscopy
Authors: Bartschat Andreas , Allgeier Stephan , Scherr Tim , Stegmaier Johannes , Bohn Sebastian , Reichert Klaus-Martin , Kuijper Arjan , Reischl Markus , Stachs Oliver , Köhler Bernd , Mikut Ralf 
Published: September 2019

AbstractCorneal confocal laser scanning microscopy is a promising method forin vivoinvestigation of cellular structures, e. g., of nerve fibers in the sub-basal nerve plexus. During recording, even slight displacements of the focal plane lead to images of adjacent tissue layers. In this work, we propose a closed-loop control of the focal plane. To detect and evaluate the visible tissues, we utilize the Bag of Visual Words approach to implement a customizable image processing pipeline for real-time applications. Furthermore, we show that the proposed model can be trained with small classification datasets and can be applied as a segmentation method. The proposed control loop, including tissue detection, is implemented in a proof-of-concept setup and shows promising results in a first evaluation with a human subject.