bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of occupation-based interventions in patients with haematopoietic malignancies undergoing chemotherapy: A pilot randomised controlled trial
Authors: Sagari Akira , Ikio Yuta , Imamura Nobuko , Deguchi Kayoko , Sakai Toko , Tabira Takayuki , Higashi Toshio 
Published: December 2018

Background/objective Chemotherapy for cancer negatively affects activities of daily living and quality of life. This study aimed to validate and compare the efficacy of two different interventions in patients with haematopoietic malignancies undergoing chemotherapy: (1) occupation-based interventions, designed using the Aid for Decision-making in Occupation Choice (ADOC) (an iPAD application) and (2) impairment-based interventions. ADOC helps promote decision-making during activities and participation in occupation-based goal setting. The impairment-based intervention group served as the comparison group and underwent impairment-based interventions focusing on dysfunction. Methods In this single-blinded pilot randomised controlled trial, 19 participants received an occupation-based intervention (n = 9) or an impairment-based intervention (n = 10). The treatment period comprised two sessions. Recruitment, compliance and outcome completion rates were calculated for the study. Effect sizes were examined for outcomes regarding physical performance, instrumental activities of daily living and quality of life as evaluated by a blinded assessor. Results In this study, 24.8% (28/113) of the eligible patients with haematopoietic malignancies were enrolled, and 67.9% (19/28) of these were retained up to the post-assessment stage. Recruitment (25%) and compliance (68%) rates were satisfactory. The Functional Assessment of Cancer Therapy-General emotional well-being and total scores were significantly higher for the occupation-based intervention group than for the impairment-based intervention group (both p < 0.05; d = 0.54, d = 0.51, respectively). Other outcomes showed no significant differences. Conclusion Occupation-based interventions designed using the ADOC application were useful for patients with haematopoietic malignancies.
Ibrutinib for the treatment of Bing-Neel syndrome: a multicenter study
Authors: Castillo Jorge J. , Itchaki Gilad , Paludo Jonas , Varettoni Marzia , Buske Christian , Eyre Toby A. , Chavez Julio C. , Shain Kenneth H. , Issa Samar , Palomba M. Lia , Pasvolsky Oren , Simpson David , Talaulikar Dipti , Tam Constantine S. , Tedeschi Alessandra , Ansell Stephen M. , Nayak Lakshmi , Treon Steven P. 
Published: December 2018

AbstractThe treatment of patients with Bing-Neel syndrome (BNS) is not standardized. We included patients with Waldenström macroglobulinemia (WM) and a radiologic and/or cytologic diagnosis of BNS treated with ibrutinib monotherapy. Response assessment was based on criteria for BNS from the 8th International Workshop for WM. Survival from BNS diagnosis (BNS survival), survival from ibrutinib initiation to last follow-up or death (ibrutinib survival), and time from ibrutinib initiation to ibrutinib discontinuation for toxicity, progression, or death (event-free survival [EFS]) were estimated. Twenty-eight patients were included in our study. The median age at BNS diagnosis was 65 years. Ibrutinib was the first line of treatment for BNS in 39% of patients. Ibrutinib was administered orally at a dose of 560 and 420 mg once daily in 46% and 54% of patients, respectively; symptomatic and radiologic improvements were seen in 85% and 60% of patients within 3 months of therapy. At best response, 85% of patients had improvement or resolution of BNS symptoms, 83% had improvement or resolution of radiologic abnormalities, and 47% had cleared the disease in the cerebrospinal fluid. The 2-year EFS rate with ibrutinib was 80% (95% confidence interval [CI], 58%-91%), the 2-year ibrutinib survival rate was 81% (95% CI, 49%-94%), and the 5-year BNS survival rate was 86% (95% CI, 63%-95%). Ibrutinib therapy is effective in patients with BNS and should be considered as a treatment option in these patients.
Cardiorespiratory and Muscle Oxygenation Responses to Isokinetic Exercise in Chronic Obstructive Pulmonary Disease
Authors: RIBEIRO FERNANDA , OUESLATI FERID , SAEY DIDIER , LÉPINE PIERRE-ALEXIS , CHAMBAH SANA , COATS VALÉRIE , MALTAIS FRANÇOIS 
Published: December 2018

ABSTRACT

Purpose
This study aimed to describe cardiorespiratory, quadriceps oxygenation, and muscle fatigue responses during a one-legged quadriceps isokinetic endurance exercise in chronic obstructive pulmonary disease (COPD) and control subjects.

Methods
Fourteen patients with COPD and 14 control subjects performed a cardiopulmonary cycling exercise test to exhaustion to assess peak oxygen consumption (V˙O2peak), minute ventilation (V˙
E
peak), and heart rate (HRpeak). They also performed a quadriceps isokinetic endurance exercise consisting in 30 maximal knee extensions at 90°·s−1 with continuous monitoring of expired gases, cardiac output, and oxygenation of the quadriceps by near-infrared spectroscopy. Total muscle work and fatigue index were also quantified.

Results
The total muscle work developed during the quadriceps isokinetic endurance exercise was 2.25 ± 0.57 kJ in COPD and 3.12 ± 0.60 kJ in controls, P < 0.001. In absolute terms, there were no between-group differences in V˙O2, V˙
E, cardiac output, and HR at the end of quadriceps isokinetic endurance exercise. However, V˙
E and HR reported that a fraction of their respective peak values during cardiopulmonary cycling exercise test were higher in COPD (V˙
E/V˙
E
peak, 69% ± 3%; HR/HRpeak, 82% ± 15%) compared with controls (V˙
E/V˙
E
peak, 45% ± 2%; HR/HRpeak, 71% ± 13%), all P < 0.05. During quadriceps isokinetic endurance exercise, quadriceps deoxyhemoglobin increased by 47% ± 31% in patients versus 33% ± 41% in controls (P < 0.05 from rest values) with a significant between-group differences (P = 0.025). The fatigue index during the quadriceps exercise was higher in COPD compared with controls.

Conclusions
Although one-legged quadriceps isokinetic endurance exercise resulted in substantial central cardiorespiratory demands in COPD, this exercise was nevertheless associated with muscle overload as evidenced by muscle deoxygenation and higher muscle fatigue index in COPD compared with controls. These findings may have implications of the design of exercise training programs in COPD.
Validation of a Mobile Application Water Planning Tool for Road Race Event Organizers
Authors: CHEUVRONT SAMUEL N. , SOLLANEK KURT J. , FATTMAN KELLY , TROYANOS CHRIS 
Published: December 2018

ABSTRACTWater planning is an important risk management concern for road race event organizers.PurposeTo compare water and cup prediction outputs from a mobile application (app) planning tool against: 1) measured group sweat losses, 2) documented event water and cup usage, and 3) traditional mathematical planning solutions.MethodsGroup mean sweating rates (L·h−1) from 12 published outdoor running studies were each compared to 12 composite averages using the Road Race Water Planner© (RRWP) app. Estimated water (gallons) and cup (number) needs were also compared with documented usage at a large marathon event and to traditional mathematical solutions.ResultsThirteen group mean sweating rates from 286 runners were compared to composite RRWP estimates. Predicted sweating rate accuracy was 92% for RRWP and ranged from 0% to 69% for traditional mathematical solutions. The 2017 Boston marathon included 27,222 runners on a day averaging 21.5°C. Water and cup usage was 31,740 gallons and 1,036,003 cups, respectively. The RRWP estimates were 33,505 gallons and 1,072,160 cups, respectively. The difference in gallons expressed as liters was 0.236 L per person. For an approximately 4-h marathon, the difference per person as a rate was <60 mL·h−1. The difference in cups was a 3.5% error. All traditional solutions gave inferior estimates to RRWP due to large errors related to fluctuations in weather, as well as complications related to water station numbers.ConclusionsThe results of the RRWP analysis indicate that it can provide event organizers with a valid, quantitative way to narrow the uncertainties of water planning related to changes in participant numbers, race distance, and weather. “Rule of thumb” alternatives are also discussed.
Sex-Specific Longitudinal Modeling of Short-Term Power in 11- to 18-Year-Olds
Authors: ARMSTRONG NEIL , WELSMAN JO 
Published: December 2018

ABSTRACT

Purpose
To investigate, longitudinally, short-term power output in relation to sex and concurrent changes in age, body mass, fat-free mass (FFM), and maturity status.

Methods
Multiplicative multilevel modeling which enables the effects of variables to be partitioned concurrently within an allometric framework was used to analyze the peak power (PP) and mean power (MP) of 388 11- to 18-yr-olds. Multilevel models were founded on 763 (405 from boys; 358 from girls) determinations of PP and MP from Wingate anaerobic tests, supported by anthropometric measures and maturity status.

Results
In both sexes, PP and MP were significantly (P < 0.001) correlated with age, body mass, and FFM. After controlling for body mass, initial models showed positive effects for age on PP and MP, with negative effects for sex and a sex by age interaction. Sex-specific models showed maturity status to have no additional effect on either PP or MP once age and body mass had been controlled for. Skinfold thicknesses in addition to body mass to provide a surrogate for FFM, yielded a significantly (P < 0.05) better statistical fit in all models compared with those based on either body mass or FFM estimated from youth-specific skinfold equations. Models founded on estimated FFM provided a significantly (P < 0.05) better fit than those based on body mass.

Conclusions
With body mass controlled for boys’ PP and MP are higher than those of girls and sex differences increase with age from 11 to 18 yr. A multilevel modeling approach has showed that in both sexes the most powerful influences on short-term power output are concurrent changes in age and FFM as reflected by the combination of body mass and skinfold thicknesses.
Hub genes in a pan-cancer co-expression network show potential for predicting drug responses
Authors: Azuaje Francisco , Kaoma Tony , Jeanty Céline , Nazarov Petr V. , Muller Arnaud , Kim Sang-Yoon , Dittmar Gunnar , Golebiewska Anna , Niclou Simone P. 
Published: December 2018

Background: The topological analysis of networks extracted from different types of “omics” data is a useful strategy for characterizing biologically meaningful properties of the complex systems underlying these networks. In particular, the biological significance of highly connected genes in diverse molecular networks has been previously determined using data from several model organisms and phenotypes. Despite such insights, the predictive potential of candidate hubs in gene co-expression networks in the specific context of cancer-related drug experiments remains to be deeply investigated. The examination of such associations may offer opportunities for the accurate prediction of anticancer drug responses. Methods: Here, we address this problem by: a) analyzing a co-expression network obtained from thousands of cancer cell lines, b) detecting significant network hubs, and c) assessing their capacity to predict drug sensitivity using data from thousands of drug experiments. We investigated the prediction capability of those genes using a multiple linear regression model, independent datasets, comparisons with other models and our own in vitro experiments. Results: These analyses led to the identification of 47 hub genes, which are implicated in a diverse range of cancer-relevant processes and pathways. Overall, encouraging agreements between predicted and observed drug sensitivities were observed in public datasets, as well as in our in vitro validations for four glioblastoma cell lines and four drugs. To facilitate further research, we share our hub-based drug sensitivity prediction model as an online tool. Conclusions: Our research shows that co-expression network hubs are biologically interesting and exhibit potential for predicting drug responses in vitro. These findings motivate further investigations about the relevance and application of our unbiased discovery approach in pre-clinical, translationally-oriented research.
Arts-based interventions for hospitalised patients with cancer: a systematic literature review
Authors: Carswell Claire , Reid Joanne , Walsh Ian , Noble Helen 
Published: December 2018

Objective: This article examines the effects of visual arts-based interventions on hospitalised patients with cancer and explore how these interventions are implemented in a clinical setting. Methods: Electronic databases searched included: MEDLINE, EMBASE, CINAHL, PsycINFO and Scopus. The search terms used were ‘neoplasm’, ‘cancer’, and ‘visual arts’. Articles were excluded if the intervention was art therapy, or if the intervention was implemented outside the clinical setting. Results: The five research articles included were all set in bone marrow transplant units. A variety of outcomes were explored, including anxiety, depression and stress. While some statistically significant improvements were identified, there was a lack of consistency and rigour in methodology across the studies. Conclusion: The literature suggests that the provision of visual arts-based interventions during hospitalisation is a beneficial experience. However, there is a dearth of literature assessing the effectiveness of visual arts-based interventions for hospitalised patients with cancer; therefore, more research is needed to establish their impact.
Diagnosis and Monitoring of Acute Infections with Emphasis on the Novel Biomarker Human Neutrophil Lipocalin
Authors: Venge Per , Xu Shengyuan 
Published: December 2018

Abstract

Background
Acute infections affect all of us at least once or twice a year. Sometimes the infection prompts a visit to our doctor, and the question asked by the patient and the doctor is whether the infection should be treated with antibiotics or not. This is an important question because unnecessary prescription of antibiotics adds to the increasing problem of antibiotics resistance. Objective means to determine whether the infection is caused by bacteria or virus, therefore, are necessary tools for the doctor.

Content
White blood cell counts, C-reactive protein, and other acute-phase reactants in blood are important tools and are commonly used, but unfortunately lack in sensitivity and specificity. In this review we describe some novel biomarkers with increased clinical performance in this regard. The superior biomarker is human neutrophil lipocalin (HNL), a protein released from activated blood neutrophils. HNL may be measured in serum, plasma, or in whole blood after activation with a neutrophil activator. The diagnostic accuracy in the distinction between bacterial and viral acute infections was shown to be in the range of 90%–95% when measured in serum or activated whole blood.

Summary
A point-of-care assay for the measurement of HNL in whole blood is currently being developed, which will allow the diagnosis of acute infections within 5–10 min. For certain indications, HNL measurement may be complemented by 1 or 2 other biomarkers, which may increase the diagnostic discrimination between bacterial and viral infections even further.
Rethinking The Courage to Be for American Culture Today
Authors: Stenger Mary Ann 
Published: December 2018

Abstract
This essay compares the cultural context for The Courage to Be with the present American context and then assesses the extent to which Tillich’s analysis is helpful in understanding and/or addressing current challenges to faith and life. Two aspects of culture that need to be addressed today are 1) the importance of our human bodies in how we live and in how we relate to others and 2) issues of justice and power. People still experience the anxieties of fate and death, doubt and meaninglessness, and guilt and condemnation, but today there is less emphasis on guilt. For some groups, a fourth anxiety of injustice and oppression dominates. American culture today is polarized politically and religiously over basic values, with people gaining courage through belonging to particular groups much more than through the courage to be as oneself. Transcendent courage participates in the power of being-itself and grounds all forms of courage, providing a religious meaning to courage and to life.
Postglacial evolution of a small lake in the South Baltic coastal zone based on geochemical, pollen and subfossil Cladocera analysis
Authors: Niska Monika , Gadziszewska Joanna , Jonczak Jerzy , Florek Wacław , Kruczkowska Bogusława 
Published: December 2018

Abstract
The paper presents sedimentary records acquired as part of the research on the coastal cliff located between 221.3 and 221.4 km of the Slovincian (Słowinskie) Coast near Debina. Palynological and subfossil Cladocera analysis of sediments combined with geochemical data proves the existence of varying environmental conditions that occurred depending on the climate fluctuation. The Debina reservoir was formed in the Late Glacial period. Mud and gyttja were deposited in an initially cold proglacial lake. Species of Cladocera identified in this period indicate a deeper oligotrophic reservoir. The end of the Late Glacial cooling inhibited the development of fauna in the reservoir. Climate change at the beginning of the Holocene improved the habitat conditions in the Debina paleolake, which is reflected in the growth of zooplankton biodiversity and enrichment of the aquatic pollen content. We distinguished three phases that illustrate the evolution of the studied aquatic-mire ecosystem. In the following periods, the trophic level in the reservoir increased and significant water-level fluctuations led to periodic transformations of reservoirs into peat bogs. Gradually, the water-level lowering and the intensification of eolian processes led to terrestrialization of the paleolake.
Wind characteristics and wind energy assessment in the Barents Sea based on ERA-Interim reanalysis
Authors: Duan Chenglin , Wang Zhifeng , Dong Sheng , Zhenkun Liao 
Published: December 2018

Abstract
The basic analysis of long-term wind characteristics and wind energy resources in the Barents Sea was carried out from 1996 to 2015 based on the ERA-Interim reanalysis dataset from ECMWF. In recent years, it has been possible to exploit the wind power resources in the Barents Sea at the hub height due to the sea ice cover retreat in the northeast direction. Based on the NSDIC monthly sea ice concentration data, the entire Barents Sea has been partitioned into the ice-free zone and the ice zone. Spatial and temporal distributions of the mean monthly and annual wind speed and wind power density are presented in both zones. Seven points were selected at different locations in the ice-free zone so as to obtain and study the wind roses, the interannual wind power variation and the annual average net electric energy output. For extreme wind speed parameters, the Pearson type III distribution provides better fitness of annual speed extrema and the Gumbel distribution performs well with higher speeds at longer return periods.
Poetik des Realen
Authors: Dröse Astrid 
Published: December 2018

Abstract
This article explores the ›poetics of the real‹ in three contemporary texts that describe the siege of Magdeburg by Tilly’s troops in 1631: The most important chronicle of the century, Merian’s Theatrum Europaeum, Bogislaw von Chemnitz’ Koniglich Schwedischer in Teutschland gefuhrter Krieg, and finally Georg Greflinger’s carmen heroicum Der Deutschen Dreysig-Jahriger Krieg - the first poetic representation of the entire war from the perspective of a contemporary. Real experience, historical facts, and literary convention are intertwined, thus creating a space of conceptual tension. The article aims to demonstrate that Greflinger’s strategies of rhetorical emplotments are part of his historiographic poetics that make the catastrophes understandable to the recipient. In this way, the literary framing supports the representation of truth. A comparison with the two historiographical texts illustrates this claim.
Suhu Permukaan Laut Perairan Indonesia dan Hubungannya dengan Pemanasan Global
Authors: Syaifullah M. DJazim 
Published: December 2018

Analisis suhu permukaan laut / SPL (Sea Surface Temperature ̶ SST) telah dilakukan di perairan Indonesia untuk melihat hubungannya dengan pemanasan global. Data yang digunakan adalah data suhu permukaan laut (sumber : National Centers for Environmental Prediction, National Weather Service, NOAA) dalam bentuk grid format ASCII selama 32 tahun (1982 – 2014), dengan skala spasial 1o x 1o geografis dan skala temporal mingguan. Analisis dilakukan dengan dua cara yaitu analisis temporal dan spasial. Analisis temporal untuk melihat trend dari anomali suhu permukaan laut rerata beberapa wilayah tertentu, sedangkan analisis spasial untuk melihat wilayah mana yang mengalami kenaikan suhu permukaan laut dan sebaliknya. Hasil analisis menunjukkan bahwa selama lebih 32 tahun telah terjadi peningkatan suhu permukaan laut di wilayah Indonesia yang bervariasi. Kenaikan suhu permukaan laut (SPL) yang paling besar terjadi di laut Pasifik Barat di sebelah utara Papua. Secara umum dapat dilihat bahwa anomali SPL di wilayah Indonesia terbagi menjadi anomali positif dan negatif yang terpisah di belahan bumi bagian selatan dan belahan bumi bagian utara.
Studying the “Gnostic Bible”
Authors: Winter Franz 
Published: December 2018

In 1983, a book entitled El Pistis Sophia Develado (Pistis Sophia Unveiled) by the Colombian esoteric writer Samael Aun Weor, born Víctor Manuel Gómez Rodríguez (1917-1977), was published posthumously. It is considered a commentary to an important ancient Gnostic text, Pistis Sophia, that is read according to the Neo-Gnostic teachings of the author. This article provides insight into Weor's specific approach to this text and the "Procrustean bed" of interpretation he applied to it.