bluuebunny/crossref_metadata_2025_split huggingface dataset:
ANGKA BANDING LIPID DI INFARK MIOKARD
Authors: Kurniawan Liong Boy , Bahrun Uleng , ER Darmawaty 
Published: October 2018

Lipid profiles are used as the regular tests which performed to predict and evaluate the risk of coronary heart disease. The routine lipid tests include total cholesterol, LDL, HDL and triglyceride level. The total cholesterol/HDL and LDL/HDL ratio are often used as predictors of coronary heart disease. This study was performed to know the lipid level and ratio by comparing the condition in myocardial infarction patients and young adult controls and to observe the percentage of their lipid level and ratio exceeding the recommended optimal value. A retrospective study was performed using secondary data of 73 myocardial infarction patients, whom hospitalized in the Intensive Cardiac Care Unit Dr. Wahidin Sudirohusodo Hospital Makassar from June 2010 to July 2011 and 21 healthy young adult as controls. The mean level of the total cholesterol, LDL, HDL, triglyceride, ratio of total cholesterol/HDL and LDL/HDL of myocardial infarction patients are compared with the control subjects were 209.99±51.70 vs 151.42±27.90 mg/dL (p=0.000), 141.18±41.92 vs 76.76±20.45 mg/dL (p=0.000), 36.96±10.47 vs 47.05±8.24 mg/dL (p=0.000), 132.27±65.67 vs 142.14±54.93 mg/dL (p=0.155), 5.99±1.71 vs 3.26±0.59 (p=0.000) and 4.06±1.45 vs 1.66±0.44 (p=0.000), respectively. It was shown that the percentage of myocardial infarction patients with total cholesterol, LDL level, total cholesterol/HDL and LDL/HDL ratio exceeding recommended optimal value were 57.53%, 63.01%, 73.97% and 86.30%, respectively. The level of total cholesterol and LDL, ratio of total cholesterol/HDL and LDL/HDL in myocardial infarction patients were significantly higher, but the HDL level was lower compared to the control subjects. The percentage of myocardial infarction patients with LDL/HDL ratio exceeding recommended optimal value was higher than the other lipid levels and ratio. Therefore, it is concluded that the LDL/HDL ratio is better in predicting coronary heart disease than other routine lipid markers.
FUSI GEN BREAKPOINT CLUSTER REGION ABELSON KINASE (BCRABL) DAN UJI HEMATOLOGIS RUTIN
Authors: Prihatni Delita , Parwati Ida , Sumantri Rahmat , Roesli Rully MA. , Nafsi Nurizzatun 
Published: October 2018

Chronic myeloid leukemia (CML) is a type of Chronic myeloproliferative disorders in pluripotencial stem cell haematopoiesis cell disease caused by somatic mutation chromosomal translocation of the Abelson (ABL) and Breakpoint Cluster Region (BCR) genes on chromosomes 9 and 22. The Breakpoint Cluster Region Abelson Kinase (BCR-ABL) gene encodes different fusion transcripts of messenger Ribo Nucleic acid (m RNA)/type of fusion gene that vary in size depending on the breakpoint in the BCR gene. The majority of CMLcases have been shown to have either b3a2 or b2a2 fusion gene. This research is a preliminary study designed to know how to identify a quantification BCR-ABL gene and expression fusion of gene and its relation to routine haematological parameters. The researchers analyzed 12 adults who were positive using a quantification ratio BCR-ABL and Glucose-6-Phosphate Dehydrogenase (G6PDH) as a house keeping gene by real-time quantitative polymerase chain reaction (RQ PCR) of chronic phase of CML patients, qualitative of translocation of BCR-ABL gene by gel agarose and routine haematological tests by a haematologic analyzer. The average quantification ratio of BCRABL gene and G6PDH was 0.0881, 50% patients had b3a2 fusion gene, 41.6% had b2a2 dan 0.4% had e1a1. Fusion gene b3a2 showed a quantification ratio, haemoglobin level and leukocyte count higher compared to b2a2 fusion gene.
KELUARGA DISULFIT PROTEIN ISOMERASE ANGGOTA 4(PDIA4) DI KANKER PAYUDARA DENGAN METASTASIS
Authors: Lembar Stefanus , Bororing Sheella R. , Lilis Lilis 
Published: October 2018

Protein disulfide isomerase (PDI) is a member of thioredoxin superfamily that is secreted in the lumen of the endoplasmic reticulum (ER) in mammalian cells. PDI catalyzes disulfide bond formation, reduction, or isomerization of newly synthesized proteins in the lumen of the RE. PDIA4 is a member of the PDI family, which is also expressed in the mammary gland. Low expression of PDIA4 probably as a result of the stress of RE in hypoxic conditions. These conditions will enhance the ability of tumor cells in mammary tissue to divide aggressively and metastasize. A total of 61 breast cancer patients aged 23âˆ’90 years (60 women and 1 man) in Jakarta, Indonesia have participated in this study after signing the informed consent letter. The diagnosis of metastasis is confirmed by the examination of bone scanning. Measurement of PDIA4 concentration is performed by the quantitative enzyme-linked immunosorbent assay (ELISA) using a commercial kits. Based on the examination of the bone scanning, there were 23 (62.5%) subjects with metastatic and 38 (37.5%) subjects non-metastatic. The mean of age of the subjects with metastatic were significantly higher than non-metastatic subjects (p=0.028), which is 51.4 (45.9–56.8) and 44.2 (40.4–48.0). The median of PDIA4 concentrations in serum of subjects with metastatic, i.e. 7.7 (1.0–37.2) ng/ml was significantly lower than non-metastatic subjects (p=0.044), i.e. 9.4 (2.2–69. 6) ng/mL. The concentration of PDIA4 in serum of breast cancer patients with metastatic were significantly lower than non-metastatic patients. It shows that the concentration of PDIA4 have decreased in incidence of metastatic breast cancer.
KUMAN DAN UJI KEPEKAAN ANTIBIOTIK DI KAKI DIABETIK
Authors: Sutjahjo Ari 
Published: October 2018

The purpose of this study was to know the bacterial pattern causing foot infections in diabetes mellitus (DM) patients and the sensitivity test results of the bacteria against various antibiotics that have been set. This research was conducted as a retrospective study using medical records. The study was carried out on diabetic foot patients of all In-patient Wards, Department of Internal Medicine, Dr. Soetomo Hospital, who met the inclusion criteria between January 1, 2003 up to December 31, 2007. The stages were classified according to the Wagner - Merrit criteria. Laboratory and clinical data were taken from the medical records of the patients who were admitted. Infected diabetic foot was found in 30.9% of patients. The causative bacteria consisted of: Pseudomonas (20.3%), Streptococcus (15.25), Klebsiella (13.9%), E.coli (12.6%), Proteus (12.6%), and Staphylococcus (11.3%). The Imipenem antibiotic showed the highest sensitivity (99.2%), followed by Norfloxacin (98.8%), Meropenem (98.2%), Ofloxacin (97.7%) and Cefuroxime (95.3). In this study, it was found that the most resistancy was to Erythromycin (46.3%) followed by Chloramphenicol (44.2%), Ceftazidime (41.1%), Cefotaxime (36.6%) and Ciprofloxacin (33.5%). It can be concluded that most of the bacteria causing the diabetic foot infections were Gram-negative aerobic bacterias and the highest sensitivity was to Imipenem, Norfloxacin, Meropenem as well as Cefuroxime.
ACQUIRED Î²âˆ’THALASSEMIA IN CHILDREN WITH ACUTE LYMPHOBLASTIC LEUKEMIA (ALL)
Authors: Shanty Larasati Maria Christina , Rumiris Mangihut , Andarsini Mia Ratwita , Ugrasena I Dewa Gede , Permono Bambang 
Published: October 2018

Thalassemias are heterogeneous group of genetic disorders. Î²-thalassemia is existed due to impaired production of beta globins chains, which leads to a relative excess of alpha globin chains. The abnormalities of haemoglobin synthesis are usually inherited but may also arise as a secondary manifestation of another disease, most commonly haematological neoplasia. This article presenting two cases of acquired Î²-thalassemia in children with ALL focusing on the diagnosis and the possible relationship between the two haematological diseases. The first case is a four (4) year old boy with ALL-L1 type at maintenance phase of chemotherapy, he suffered from anaemia with Hb 8.0 g/dL, WBC 22,600/mm3 and platelets count of 200,000/mm3, peripheral blood smear revealed anisocytosis, polychromes, hypochromia, basophilic stippling, and normoblastocytes. The result of Hb electrophoresis of Hb A of 54.9%, Hb F of 29.4%, Hb E of 13.4% and Hb A2 of 2.3%. The patient was diagnosed as ALL-L1 type and Î²-thalassemia. The second case, is a 13 year old girl with remission ALL-L1 type after chemotherapy, she suffered from anaemia with Hb 6.7 g/dL, WBC 12,400/mm3, platelet count was 200,000/mm3, and peripheral blood smear obtained anisocytosis, hypochromia, normoblastocytes, myelocytes and basophilic stippling. The result of Hb electrophoresis are: Hb F 0.41%, Hb A1c 0.78%, Hb A2 2.95% with the conclusion of a Î²-thalassemia trait, this patient was diagnosed with ALL-L1 type remission + Î²-thalassemia trait. The case reviewers assume that acquired Î²-thalassemia which happened in those patients were the altered expression of globin chain which mechanism for this syndrome might be the acquisition of a mutation that affects RNA or proteins involved in Î²-globin gene regulation and resulting the reduction of the (Î±/Î²)-globin biosynthetic ratios, or/and associated with chemotherapy-inducement.
ANALISIS BEBAN KERJA DI INSTALASI LABORATORIUM
Authors: Kurniati Amiroh , Tahono Tahono 
Published: October 2018

Human resources (HR) planning is associated with an institution's strategic plan, so the study of the required number of support personnel is in line with the direction of business development planning of the Laboratory Installation Unit. WISN (work load indicator staff need) method is a calculation based on the analysis of health manpower needs of the workload (work load analysis) and is considered as the most accurate method to calculate labour requirements in short-term. Based on the results of the analysis of manpower needs at the Laboratory Installation of Lung Health of the Community Hall Surakarta, it is known that there is still a lack of a number of five (5) persons of the health laboratory staff. The persons still lacking consist of: one (1) laboratory person related to clinical pathology laboratory, one (1) laboratory person for smear microscopy laboratory, and still three (3) microbiology laboratory persons. These persons are needed to be able to carry out the activities for a good laboratory service, and quality which is in accordance with the related applicable standards.
PNEUMOCYSTIS PNEUMONIA (PCP) DI PENDERITA HIV DAN AIDS DENGAN KELAINAN PARU
Authors: Prasetyo R. Heru 
Published: October 2018

PCP is one of the most common opportunistic infection in HIV and AIDS patients. A definitive diagnosis of PCP in HIV and AIDS patients in Dr. Soetomo General Hospital Surabaya has not been previously done. A definitive diagnosis have the role in the therapy and to prevent the illness as well. PCP is diagnosed by using a microscope to indentify Pneumocystis jerovecii in the lung fluid or tisuue. The objective of this study was to know how to detect Pneumocystis jerovecii in the sputum samples and to know the determination of the prevalence of PCP in HIV and AIDS patients suffered with pulmonary symptom who were hospitalized in Dr. Soetomo General Hospital Surabaya. This research was carried out by a cross sectional study utilizing waste sputum samples from HIV and AIDS patients. The detection of Pneumocystis jerovecii used Giemsa stain. Six sputum samples among 18 sputum samples (33.33%) HIV and AIDS patients were Pneumocystis jerovecii positive. Based on this findings HIV and AIDS patients with pulmonary symptoms should be suspect having the possibility of PCP as opportunity infection in HIV and AIDS existed, and there for the detection of the Pneumocystis jerovecii in sputum sample must becoming routinelycarried out in the laboratory examination for HIV and AIDS patients which also suffering pulmonary symptom.
BAKTERI AEROB DAN BAKTERI PENYEBAB PENYAKIT DI neonATAL InTenSIve CARe unIT
Authors: Suriyanti Suriyanti , Handayani Irda , Rusli Benny 
Published: October 2018

Infectious diseases are still the main problem due to the potency of life threatening for neonates. Patients in the Neonatal Intensive Care Unit (NICU) are at risk for nosocomial infections resulting from the exposure to invasive procedures and medical equipments such as ventilator, catheter, Continuous Positive Airway Pressure (CPAP), incubator and antibiotics treatment. This study was aimed to know the related condition in NICU Dr. Wahidin Sudirohusodo Hospital Makassar by identification and determining the pathogenic bacteria colony counts of incubator and CPAP. The study design was a cross sectional method, by using incubator and CPAP as sample instruments, both equipments were sterilized at the NICU. The samples were collected and evaluated in July 2011. Samples were collected by usinga swab which was wiped to the instrument and put into Buffer Phosphate Saline (BPS); then diluted and put into Plate Count Agar (PCA) media for culture. The result of this study showed that there were no bacteria colony in the incubator, while in CPAP Acinetobacter calcoaceticus with bacteria colony count approximately 3.4í—102 CFU/m3 were found. The researchers concluded that the incubator was sterile to bacteria, however in the CPAP bacteria from the strain of Acinetobacter calcoaceticus were found
HUBUNGAN OKSIDA NITRAT DAN NILAI HISTOPATOLOGIS PADA ENDOTOKSEMIA
Authors: Sotianingsih Sotianingsih , Suharyo Suharyo , S Lisyani , HA Guntur 
Published: October 2018

Lipopolysaccharide (LPS) is an endotoxin from the outer membrane of Gram-negative bacteria, which has an important role in the occurrence of sepsis. Exposure to LPS will stimulate increase of nitric oxide (NO). Nitric oxide is a bioregulator of apoptosis and has some sepsis prognostic role of apoptosis regulators within the gastrointestinal cells. The objective of the study is to know if endotoxemia induces an increase in NO levels and histopathology scores as well as the existing relationship between them. This study is an observational intervention. The subjects were 48 male mice Balb/C, divided into 2 groups. The samples consisted of 24 tail as control group (group A) and 24 as treatment group (group B). The A group as well as the B group is divided into 4 subgroups according to the time of termination. The levels of NO were examined by Griess method. Histopathology score was examined by HE and read as a score of 0–5. There was a statistically significant difference between the mean NO in the treatment group with the control group at the termination of the group of 12h (p=0.009), 24h (p=0.015), 36h (p=0.014), 48h (p=0.002) and the whole group (p=0.0001), as well as between the mean histopathology score at the termination time of 12 h (p=0.0001), 24h (p=0.0001), 36h (p=0.0001), 48h (p=0465) and the whole group (p=0.0001). Increase in NO and histopathology scores in all groups of mice (r=0.527) showed a statistically significant correlation. NO levels and histopathology scores are increased during endotoxemia and thus have a significant correlation.
KADAR FIBRIN MONOMER DAN UKURAN INFARK DI STROK ISKEMIK AKUT
Authors: Kartini Ani , Arif Mansyur , Hardjoeno Hardjoeno 
Published: October 2018

Coagulation activation and thrombosis frequently exist in ischemic stroke, thrombus formation can be detected early by the presence of fibrin monomer. The purpose of this study was to know the correlation of fibrin monomer level with cerebral infarct size in acute ischemic stroke patients. This was a cross sectional study with a total of 39 samples. The fibrin monomer level was determined by immunoturbidimetry method using STA-Compact and the measurement of the infarct size was done by CT scan of the head using Broderick formula. The results of this study showed that the median level of fibrin monomer in acute ischemic stroke with nonlacunar infarct type and lacunar infarct type were 14.46 Î¼g/mL and 4.29 Î¼g/mL, respectively. Mann-Whitney test showed there was a significant difference of fibrin monomer levels between nonlacunar infarct type and the lacunar type, p=0.000. The cut-off point analysis result of the fibrin monomer level was 5.96 Î¼g/mL with a sensitivity of 88.9% and specificity of 76.4%, respectively. Spearman correlation test showed that fibrin monomer level was positively correlated with cerebral infarct volume in acute ischemic stroke (r=0.56, p=0.000). Based on this study, it can be concluded that fibrin monomer level can be used as a marker to predict the type of cerebral infarct and volume of acute ischemic stroke as well.
KADAR INTERLEUKIN-8 KANKER PAYUDARA
Authors: Juranah Juranah , Widaningsih Yuyun , Hamdani William , Pakasi Ruland DN , Bahrun Uleng 
Published: October 2018

Metastasis is the major cause of increased morbidity and mortality in breast cancer. Interleukin-8 has a contribution in the spread of the tumour cells. This study was aimed to know IL-8 levels in patients with metastasic and non metasatic breast cancer by analyzing. A cross sectional study was performed at the Dr. Wahidin Sudirohusodo, Ibnu Sina and Labuang Baji hospitals during September to December 2011. Laboratory examinations were done in the Research Centre of the Medical Faculty, University of Hasanuddin. Fiftysix (56) subjects with breast cancer were examined. The results showed that the levels of IL-8 in metastatic and non metastatic breast cancer were 13.73 pg/mL and 10.48 pg/mL respectively. Mann-Whitney test showed no significant difference of IL-8 level between them, (p=0.09). When the subjects were divided into early and advance stages, the mean levels of IL-8 were 8.035 pg/mL and 12.052 pg/mL, respectively, showing a significant difference by Mann-Whitney test (p=0.009). Based on this research, the level of IL-8 can be considered as a marker in predicting the prognosis of breast cancer. A further research in cohort studies which specific metastasis crawl method is advised by the researchers, these are suggested to allow the determination of the risk factors.
ST2 DI INFARK MIOKARD AKUT
Authors: Priyanto Hery , Nugraha Jusak , Edijanto SP 
Published: October 2018

Acute Myocardial Infarction (AMI) is a major problem threatening Indonesian inhabitants as well as in many countries. Each year AMI patients are increasing. ST2 is a novel cardiac marker for the diagnosis and prognosis of acute myocardial infarction. The purpose of this study was to know and find the diagnostic value of ST2 serum in patients with AMI. This cross sectional study was conducted on 46 patients who had chest pain as the main complaint in the Emergency Department, Dr. Soetomo Hospital, Surabaya between April 20 to July 20, 2013. The sera were examined for ST2, cTn-T, the diagnostic value was determined using the acute myocardial infarction clinical criteria according to the Universal Definition of Myocardial Infarction (2007) as the gold standard. The results of ST2 serum levels measurement showed a sensitivity of 83% and specificity of 70% at a cut-off value of ST2 16.64 ng/mL and AUC 0.878, p=0.000. The concordance examination between using cTn-T levels and ST2 was 48.1%. A significanct correlation was obtained with a correlation coefficient r=0.489, p=0.001 between the levels of cTn-T and ST2. Based on this study, the ST2 serum levels can be used for screeningto aid the diagnosis of acute myocardial infarction. However, there is a weak correlation and concordance between cTn-T with ST2. Thus, the researchers need a further study to determine the diagnostic value of ST2 for the detection of acute myocardial infarction.
Comparison of cryoballoon and radiofrequency ablation techniques for atrial fibrillation: a meta-analysis
Authors: Maltoni Susanna , Negro Antonella , Camerlingo Maria D. , Pecoraro Valentina , Sassone Biagio , Biffi Mauro , Boriani Giuseppe 
Published: October 2018

AimsTo perform an updated meta-analysis to assess efficacy, safety and technical performance of pulmonary vein isolation using cryoballoon or radiofrequency catheter ablation in patients with paroxysmal or persistent atrial fibrillation.MethodsIn June 2017, databases and websites were systematically searched for systematic reviews, randomized controlled trials and observational studies reporting data on efficacy, safety and technical performance outcomes at follow-up at least 12 months. Researchers independently assessed records’ eligibility, inclusion and methodological quality of included studies.ResultsSix randomized controlled trials and 25 observational studies – 11 853 patients were included. Studies on paroxysmal atrial fibrillation were 29 and included 11 635 patients. Meta-analysis results showed no difference between cryoballoon and radiofrequency in terms of recurrent atrial fibrillation [risk ratio 1.04, 95% confidence interval (CI) 0.98–1.10] or atrial tachyarrhythmias (risk ratio 1.04, 95% CI 1–1.08) and fluoroscopy time (mean difference −1.92 min, 95% CI −4.89 to 1.05). Cryoballoon ablation was associated with fewer reablations (risk ratio 0.79, 95% CI 0.64–0.98), lower incidence of pericardial effusion (risk ratio 0.52, 95% CI 0.31–0.89) and cardiac tamponade (risk ratio 0.33, 95% CI 0.18–0.62) and shorter total procedural time (mean difference −23.48 min, 95% CI −37.97; −9.02) but with higher incidence of phrenic nerve palsy (risk ratio 5.43, 95% CI 2.67–11.04). Prespecified subgroup analysis confirmed overall results as for freedom from atrial fibrillation and atrial tachyarrhythmias. Only two observational studies included patients with persistent atrial fibrillation, thus hindering any conclusion in this population.ConclusionIn patients with paroxysmal atrial fibrillation, cryoballoon and radiofrequency ablation produce similar results in terms of freedom from recurrent atrial fibrillation or atrial tachyarrhythmias but with a different safety profile, being cryoballoon ablation less associated with cardiac complications but more likely to cause phrenic nerve palsy.
N. RIANTIARNO, TEATER KOMA, DAN REFLEKSI POLITIK DALAM KARYA SASTRA
Authors: Harimansyah Ganjar 
Published: October 2018

This paper was originally the result of a research discussing the syntagm “politics in literature” which reflected a certain relationship between politics as a form of collective practice and literature as a historical regime of the art of writing. The phenomena of N. Riantiarnno as a litterateur, Teater Koma as a theatre institution and Trilogy of Cokroach Opera as a literature piece show a certain aesthetic and politics elements hidden inside the literatures as the reflection of society which is influenced by its history and politics state. On the other hand, the relation between litterateurs, the institution where they worked, the texts they created and the consuming societies indicates that the production and consumption of literature pieces are not separated from practical politics practice. AbstrakTulisan ini merupakan hasil penelitian yang berangkat dari sintagma "politik dalam karya sastra" yang merefleksikan hubungan tertentu antara politik sebagai bentuk praktik kolektif dan sastra sebagai rezim historis dari seni menulis. Penelitian ini menggunakan prinsip analisis isi kualitatif dalam kerangka analisis wacana kritis. Di dalam tulisan ini diungkapkan hubungan antara fenomena N. Riantiarno sebagai sastrawan, Teater Koma sebagai institusi teater, dan teks drama sebagai karya sastra memperlihatkan elemen estetik dan politik tertentu yang tersembunyi di dalam karya sastra sebagai refleksi masyarakat yang dipengaruhi kondisi sejarah dan politiknya. Di sisi lain, hubungan sastrawan, institusi tempat ia berkarya, teks yang dihasilkannya, dan masyarakat pengonsumsi karya tersebut memperlihatkan bahwa pemroduksian dan pengonsumsian sebuah karya sastra pun taklepas dari aspek politik praktis.