bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sexual and Reproductive Health Needs of Women with Polycystic Ovarian Syndrome: A Scoping Review and Narrative Synthesis
Authors: Kalhor Mehri , Mohammadi Eesa , Shahali Shadab , Amini Leila , Moghaddam-Banaem Lida 
Published: August 2019

Abstract
Background: Polycystic ovarian syndrome (PCOs) is one of the most common endocrine disorders in women throughout the world affecting their sexual/ reproductive health (SRH). Objective: This scoping review aims to identify SRH needs of women with PCOs
Methods: PubMed, SCOPUS, Google Scholar, MEDLINE, Science Direct, Ovid and the Cochrane Library were screened from 2000 to 2019. English or Persian peer reviewed and gray literature sources were included. In the primary search, 52 articles were obtained; and finally by narrative synthesis framework for quality assessment, and data analysis and synthesis 27 articles were analyzed.
Results: From the 27 selected articles, 9 main themes were obtained i.e.: Complications and problems affecting patients, Lifelong effect of PCOs on reproductive patterns , PCOs and adverse reproductive and pregnancy outcomes, Information needs and preferences of patients about health outcomes and their application for treatment and management of lifelong health outcomes, Financial burden of disease, The effect of PCOs on life experiences and quality of life of affected women, Sexual disorders, Psychological concerns and issues, Femininity feelings and roles
Conclusion: Comparison of the 9 themes developed in this study with SRH needs in women, revealed that some of the issues, such as psychological challenges, patients' femininity feelings and roles and financial burden of disease have been ignored in providing SRH services, and should be taken into consideration.
Prevalence of modern contraceptive utilization and associated factors among women of reproductive age from 36-49 years in Ethiopia
Authors: Asrat Dereje Zena , Achamyeleh Anemaw Asrat , Ayalew Agumas Fentahun 
Published: August 2019

Abstract
Background: One of the major problems in developing countries is the increasing growth of population which in fact is a serious threat for the global community. Modern Contraceptive use allows people to attain their desired number of children and determine the spacing of pregnancies. The main objective of this study is to assess the Prevalence of modern contraceptive utilization and associated factors among women of reproductive age from 36-49 years in Ethiopia.
Methodology: A community based, cross-sectional study was employed from January 1 to June 30, 2016, among women of reproductive age from 36-49 years in all regions of Ethiopia. A multi-stage sampling procedure was used to select 3260 study participants. A pretested structured questionnaire was used to collect data, and data collectors who had completed high school were involved in the data collection process. A bivariate, multivariable logistic regression model was fit and statistical significance was determined with odds ratios and 95 % confidence level. Before preceding data analysis, the necessary assumptions for the application of multiple logistic regressions was checked by Hosmer and Lemeshow Test through forward LR method.
Result: The overall modern contraceptive prevalence rate was found to be 17%. Being wealthy (Adjusted Odds Ratio=4.120 95%CI (2.853, 5.949), higher educated (Adjusted Odds Ratio =3.329, 95%CI (2.065, 5.368) and having more numbers of living children (Adjusted Odds Ratio =1.714, 95% (1.328, 2.212) was significantly associated with use of modern contraceptive methods.
Conclusion: The utilization of modern contraceptive method was low. Contraceptive utilization was associated with some socio-economic and socio-demographic factors like age, educational status, women wealth index and number of children. Therefore, expanding contraceptive services confers substantial benefits on women, their families and society. All stakeholders, including the Ethiopian government and the private sector, should increase their investment in modern contraceptive services
Keywords: modern Contraceptives use, Associated Factors and Women
The grapevine homeobox gene VvHB58 influences ovule and fruit development through multiple hormonal signaling pathways
Authors: Li Yunduan , Zhang Songlin , Dong Ruzhuang , Wang Li , Yao Jin , Nocker Steve van , Wang Xiping 
Published: August 2019

Abstract
Abstract
Background: Seedlessness is one of the most valuable traits in grapevine (Vitis vinifera), especially for the raisin and table grape industries. Previous transcriptome analyses of seed development in grape hybrids suggested that specific homeodomain transcription factors are involved in seed abortion in seedless cultivars. However, the molecular mechanism of homeobox gene regulating seed abortion is rarely reported.
Results: Here, we report that the grapevine VvHB58 gene, encoding a homeodomain-leucine zipper (HD-Zip I) transcription factor, participates in regulating fruit size and seed number. The VvHB58 gene was dramatically differentially expressed during seed development between seedless and seeded cultivars. Subcellular localization assays revealed that the VvHB58 protein was located in the nucleus. Transgenic expression of VvHB58 in tomato led to loss of apical dominance, a reduction in fruit pericarp expansion, reduced fruit size and seed number, and larger endosperm cells. Analysis of the sequence and cytosine methylation within the VvHB58 promoter indicated that the differential expression during seed development between seedless and seeded grapes may be caused by different transcriptional regulatory mechanisms rather than promoter DNA methylation. Measurements of five classic endogenous hormones and expression analysis of hormone-related genes between VvHB58 transgenic and nontransgenic control plants showed that expression of VvHB58 resulted in significant changes in auxin, gibberellin and ethylene signaling pathways. Additionally, several DNA methylation-related genes were expressed differentially during seed abortion in seedless and seeded grapes, suggesting hypomethylation during ovule development may be associated with seed abortion.
Conclusion: VvHB58 has a potential function in regulating fruit and seed development by impacting multiple hormonal pathways. These results expand understanding of homeodomain transcription factors and potential regulatory mechanism of seed development in grapevine, and provided insights into molecular breeding for seedless grapes.
Radiosurgery and fractionated stereotactic body radiotherapy for patients with lung oligometastases
Authors: Kalinauskaite Goda , Tinhofer Ingeborg , Kufeld Marcus , Kluge Anne Kathrin , Grün Arne , Budach Volker , Senger Carolin , Stromberger Carmen 
Published: August 2019

Abstract
Background

Patients with oligometastatic disease can potentially be cured by using an ablative therapy for all active lesions. Stereotactic body radiotherapy (SBRT) is a non-invasive treatment option that lately proved to be as effective and safe as surgery in treating lung metastases (LM). However, it is not clear which patients benefit most and what are the most suitable fractionation regimes. The aim of this study was to analyze treatment outcomes after single fraction radiosurgery (SFRS) and fractionated SBRT in patients with lung oligometastases and identify prognostic clinical features for better survival outcomes.

Methods

Fifty-two patients with 94 LM treated with SFRS or fSBRT (Cyberknife, Novalis) between 2010 and 2016 were analyzed. The characteristics of primary tumor, LM, treatment, toxicity profiles and outcomes were assessed. Kaplan-Meier and Cox regression analyses were used for estimation of local control (LC), overall survival (OS), progression free survival and distant metastases free survival (DMFS).

Results

Ninety-four LM in 52 patients were treated using SFRS/fSBRT with a median of 2 lesions per patient (range: 1–5). The median prescription dose for SFRS was 24 Gy (range: 17-26) compared to 48 Gy (range: 24-75) in 2-12 fractions in fSBRT. The median follow-up time was 21 months (range: 3-68). LC rates at 1 and 2 years for SFSR vs. fSBRT were 89% and 83% vs. 75% and 59%, respectively (p=0.026). LM treated with SFSR were significantly smaller (p=0.001). The 1 and 2-year OS rates for all patients were 84% and 71%, respectively. In univariate analysis treatment with SFRS, an interval of ≥ 12 months between diagnosis of LM and treatment, non-colorectal cancer histology and BED <100 Gy were significantly associated with better LC. However, none of these parameters remained significant in the multivariate Cox regression model. OS was significantly better in patients with negative lymph nodes (N0), Karnofsky performance status (KPS) > 70% and DMFS ≥ 12 months. There was no grade 3 acute or late toxicity.

Conclusions

We observed good LC and low toxicity rates after SFRS for small lung metastases. Long DMFS, good KPS and N0 predicted longer OS in patients with lung oligometastases.
Microbiome composition comparison in oral and atherosclerotic plaque from patients with and without periodontitis
Authors: Isoshima Daichi , Yamashiro Keisuke , Matsunaga Kazuyuki , Taniguchi Makoto , Matsubara Takehiro , Tomida Shuta , Ota Shinzo , Sato Michiyoshi , Shimoe Yutaka , Kohriyama Tatsuo , Zulema Arias , Omori Kazuhiro , Yamamoto Tadashi , Takashiba Shogo 
Published: August 2019

Abstract
Background

There is no conclusive evidence regarding a causal relationship between periodontitis and atherosclerosis. In this study, we examined the microbiome in the oral cavity and atheromatous plaques from atherosclerosis patients with or without periodontitis to investigate the role of oral bacteria in the formation of atheromatous plaques. We chose four patients with and without periodontitis, who had undergone carotid endarterectomy. Bacterial samples were extracted from saliva on the tongue surface, from periodontal pocket (during the oral examination), and from the atheromatous plaques. We investigated the general and oral conditions from each patient and performed next-generation sequencing analysis for all bacterial samples.

Results

There were no significant differences between both groups concerning general conditions. However, the microbiome patterns of the gingival pocket showed differences depending on the absence or presence of periodontitis, while those of the saliva were relatively similar. The microbiome pattern of the atheromatous plaques was entirely different from that in saliva present on the tongue surface and gingival pocket, and oral bacteria were seldom detected. However, the microbiome pattern in atheromatous plaques was different in the presence or absence of periodontitis.

Conclusion

These results indicated that oral bacteria did not affect the formation of atheromatous plaques directly. However, the metabolic products of microbiome or the host inflammatory response might indirectly influence the composition of atheromatous plaques.
House-hold contact tuberculosis screening adherence and associated factors among tuberculosis patients attending at Health facilities in Gondar town, Northwest, Ethiopia
Authors: Shiferaw Dessie Alemnew , Mekonnen Habtamu Sewunet , Abate Addisu Taye 
Published: August 2019

Abstract
Abstract
Background: Contacts of patients with tuberculosis have a substantial risk of developing the disease. Household contact screening has recently been recommended as a strategy to enhance case detection in high-burden countries but there is no enough information in Gondar Town regarding household contact screening practice among TB patients.
Objective: The aim of this study was to assess the magnitude of household contact screening adherence and associated factors among adult tuberculosis patients attending at health facilities in Gondar Town, Northwest Ethiopia.
Methods: An institution-based cross-sectional study was conducted from March 1 to 30, 2019 on 404 tuberculosis patients attending at health facilities in Gondar Town. Epi-Info version 7 for data entry and SPSS version 20 for data analysis were used. Descriptive statistics were carried out to illustrate the means, standard deviations, and frequencies of study variables. Bivariable and multivariable logistic regression analyses were used to identify variables having a significant association with the dependent variable.
Results: From 412 study populations, 404 participated with 98.06% response rate. The overall household contact TB screening adherence was 47.5% (95% CI: 43.1, 52.5). In the multivariable analysis, certificate and above educational level (AOR=2.83, 95% CI:1.40,5.67), sufficient knowledge on TB (AOR=8.26, 95% CI:4.34,15.71), satisfied patients with delivered health care service (AOR=3.26, 95% CI:1.58,6.76), health education given by health care worker (AOR=2.60, 95% CI:1.54,4.40),and HIV/AIDS co-infection (AOR=3.54, 95% CI:1.70,7.39), were factors associated with household contact TB screening adherence.
Conclusion: Compared to other previous studies, the current finding was high but it was low as compared with WHO and Ethiopian Ministry of Health recommendations (all persons having TB contact should be screened). Educational status, knowledge on TB, satisfaction with delivered health care service, health education given by HCWs about TB and HIV/AIDS co-infection were factors associated with household contact TB screening practice. Thus, strengthening household TB contact screening and educational programs regarding the risk of getting TB infection from household contacts is crucial.
Keywords: Contact screening, household, adherence, tuberculosis, Ethiopia
Expression of cytoglobin and PGC-1α is high during tail tissue regeneration of the house gecko (Hemidactylus platyurus)
Authors: Novianti Titta , Juniantito Vetnizah , Jusuf Ahmad Aulia , Arida Evy Ayu , Sadikin Mohamad , Jusman Sri Widia A. 
Published: August 2019

Abstract
Abstract
Background
Tissue regeneration is a process that need a high demand of oxygen and energy supply. Cytoglobin (Cygb) is a hexacoordinate globin superfamily that possesses strong oxygen-binding ability. Cygb also has a role in preventing cells from oxidative stress and carrying oxygen into the mitochondria. The production of energy for regeneration is associated with mitochondria, especially mitochondrial biogenesis. The peroxisome proliferator-activated receptor gamma coactivator (PGC-1α) is aprotein that plays an important role in regulating mitochondrial biogenesis. The house gecko (Hemidactylus platyurus) is a reptile with high ability for tissue regeneration in its tail. The house gecko was selected as the animal model for this research to analyse the role of Cygb which is associated with oxygen supply and PGC-1α that is related to energy production in tissue regeneration.
Results
The curve for the tail growth showed three different phases. Cygb mRNA was highly expressed during tissue regeneration. PGC-1α mRNA was expressed earlier than Cygb, with a lower expression but still higher than the control.
Conclusions
During the tail tissue regeneration process of the house gecko, the expression of Cygb and PGC-1α were dynamic and relatively higher than their expression observed in the control. Cygb and PGC-1α were suspected to have a significant role in the tissue regeneration process.
Achieving water security in peri-urban Yangon: exploring the local governance processes
Authors: Groot Rebecca , Bayrak Mucahid Mustafa 
Published: August 2019

Abstract
Many cities in the Global South lack the capacity to provide water security to their inhabitants. Peri-urban areas are especially vulnerable to water insecurity. This study concerns the impact of (good) governance on water security among formal and informal settlers residing in Hlaing Thar Yar Industrial Zone (HTIZ), a peri-urban area belonging to Yangon, Myanmar. Through employing mixed methods, we investigate the dynamics of water security by studying the governing processes which shape it on a local level. In HTIZ, various challenges related to water security come together. Our findings reveal that water security in HTIZ was achieved for the majority of the formal settlers, whereas this was not the case for the majority of the informal (riverbank) settlers. Although a well-organized needs-driven system of local water vendors supplied water to the local population there was a high risk of contamination by domestic pollution (e.g., Escherichia coli) and industrial effluent, in addition to the relatively high price of the water. The identified water insecurities were driven on an institutional level by the lack of capacity and priority given to supplying and protecting informal settlers. Absence of environmental monitoring and enforcement, and the perceptions of government officials further exacerbated water insecurity.
Determinants of water lobbying: irrigators' behavior in a water-stressed basin
Authors: Esteban Encarna , Dinar Ariel , Albiac José 
Published: August 2019

AbstractThe design and implementation of water policies to address scarcity problems are largely shaped by the behavior of interest groups and their ability to influence policymakers. Different and opposed interests of stakeholders regarding policies trigger water conflicts and, frequently, lead to the failure of the implemented regulation. Departing from political economy theory, we empirically estimate the determinants that affect the level of lobbying effort and effectiveness by water interest groups for influencing water policy. The findings are based on data collected by a survey administered among different irrigators' groups, in a water-stressed river basin (the Jucar River Basin in Spain) that vie to increase their water allocations. Our results demonstrate how lobbying effort depends on the involvement of the interest groups, the energies exerted to sway water authorities, and on the variation among the group members. Lobbying effectiveness is a function of the effort exerted. Furthermore, both functions depend on the intrinsic characteristics of the group's members. While the empirical results corroborate several main statements of the theory of lobbying and interest groups, some deviations based on the empirical application remain.
Advancing the Science of Recruitment for Family Caregivers: Focus Group and Delphi Methods
Authors: Hansen Dana , Petrinec Amy , Hebeshy Mona , Sheehan Denice , Drew Barbara L 
Published: August 2019

Background
Successful recruitment of participants is imperative to a rigorous study, and recruitment challenges are not new to researchers. Many researchers have used social media successfully to recruit study participants. However, challenges remain for effective online social media recruitment for some populations.

Objective
Using a multistep approach that included a focus group and Delphi method, researchers performed this study to gain expert advice regarding material development for social media recruitment and to test the recruitment material with the target population.

Methods
In the first phase, we conducted a focus group with 5 social media experts to identify critical elements for effective social media recruitment material. Utilizing the Delphi method with 5 family caregivers, we conducted the second phase to reach consensus regarding effective recruitment videos.

Results
Phase I utilized a focus group that resulted in identification of three barriers related to social media recruitment, including lack of staff and resources, issues with restrictive algorithms, and not standing out in the crowd. Phase II used the Delphi method. At the completion of Delphi Round 1, 5 Delphi participants received a summary of the analysis for feedback and agreement with our summary. Using data and recommendations from Round 1, researchers created two new recruitment videos with additions to improve trustworthiness and transparency, such as the university’s logo. In Round 2 of the Delphi method, consensus regarding the quality and trustworthiness of the recruitment videos reached 100%.

Conclusions
One of the primary challenges for family caregiver research is recruitment. Despite the broad adoption of social media marketing approaches, the effectiveness of online recruitment strategies needs further investigation.
Digitalization On Students Scoring System of SMPN 18 Bekasi
Authors: Haq Fesa Asy Syifa Nurul , Nuryuliani Nuryuliani 
Published: August 2019

Information technology has been supporting the development of school services in the world. But there are still many schools does not using the information technology at all - specially in Indonesia, for example at SMPN 18 Bekasi. As usually like another school they only using Ms. Word and Ms. Excel applications. That is make many differences output in format scoring and mistakes while filling score on the students report format. The application of academic information system in this research have developed using PHP, HTML and MySQL as programming language. It named SIADHEL, means Eighteen Academic Information System (Sistem Informasi Akademik Delapan Belas) . The aims of this project is to provide a good tools for students or their parents to receive the exactly, fast and accurate informations of their students scoring. Teachers can use an integrated and accurate tools as facility to provide data for the Principal to make new policies. This application could be opened by every browser platform, so it will make easier for the users to access the program wherever and anytime.
Toxicity Test for Evaluating Food Safety of New Edible Seaweeds, Enteromorpha sp. and Laurencia sp.
Authors: Isnansetyo Alim , Istiqomah Indah , Widaningroem Retno , Triyanto Triyanto , Safia Rina Anggraeni , Yosita Riesa , Helmiati Senny 
Published: August 2019

Seaweeds are potential foodstuff and source of bioactive substances that are very useful in the food and pharmaceutical industries. The objective of this study was to evaluate toxicity of aqueous extracts of seaweeds by Brine shrimp lethality test (BLT) and cytotoxicity test. The seaweeds used in this study were Enteromorpha sp. and Laurencia sp. collected from the Gunungkidul coastal line. The cytotoxicity test was performed against a normal cells line of Vero cells and a cancer cells line of HeLa cells. The cells lines were cultured in M119 medium with addition of 10% FBS and incubated at 37°C in CO2 incubator until confluent. Cells were harvested and cultured in 96 microplate with an initial density of 2x104 cells / 100 ml / well. The cells lines were treated with seaweed extracts at 24 hours after incubation. After additional 24 h incubation, the cell proliferation was observed by MTT method (3- [4,5-dimethylthiazol-2-yl] -2,5- diphenyltetrazolium bromide.The results showed that the two aqueous extract were not toxic in the BLT test, and did not exhibited any cytotoxicity activity against HeLa and Vero cells lines. Concentration-dependent cell proliferation was also not found. This results indicated that Enteromorpha sp. and Laurencia sp. extracts were no cytotoxic and might be consumed safely. These overall results suggested that the two seaweeds might be developed to be a new foodstuff for humans.