bluuebunny/crossref_metadata_2025_split huggingface dataset:
Species distribution modelling of Ornithodoros spp. in California with consideration of climate variation and identification of ASFV high-risk areas
Authors: Gonzalez-Crespo Carlos , Jourdan-Pineau Hélène , Patterson Laura , Pires Alda F. A. , Martínez-López Beatriz 
Published: November 2024

Abstract

Background
African swine fever virus (ASFV) is a highly contagious pathogen affecting domestic and wild pigs, with soft ticks (Ornithodoros spp.) acting as significant vectors. Understanding the distribution of Ornithodoros ticks in relation to environmental variables is crucial for anticipating ASFV transmission risk areas.
Methods
This study employed species distribution modeling (SDM) using MaxEnt and Random Forest algorithms to predict the suitable habitat of Ornithodoros coriaceus, O. hermsi, and O. parkeri in California under current and future climate scenarios (2061–2080). The SDMs incorporated climate, edaphic, topographic, and habitat variables, with models evaluated through 10-fold cross-validation using the Area Under the Curve (AUC).
Results
Key predictors included Isothermality (BIO3), Precipitation Seasonality (BIO15), and soil type (Entisols). The present habitat suitability for Ornithodoros spp. covered approximately 117,208 km², projected to increase by 6,869.5 km² under future conditions. The spatial co-occurrence analysis highlighted an overlap of approximately 37,242.75 km² between Ornithodoros spp. habitats and feral/domestic pig distributions, expanding to 39,213 km² under future scenarios.
Conclusions
Identifying high-risk areas for ASFV transmission through SDMs provides valuable insights for targeted surveillance and biosecurity measures. The study emphasizes the need for integrated vector-host management and proactive strategies to mitigate ASFV risk in California.
DNA Methylation Signature of a Lifestyle-based Resilience Index for Cognitive Health
Authors: Wang Lily , Zhang Wei , Lukacsovich David , Young Juan , Gomez Lissette , Schmidt Michael , Martin Eden , Kunkle Brian , Chen Xi , O’Shea Deirdre , Galvin James 
Published: November 2024

Abstract

Cognitive resilience (CR) contributes to the variability in risk for developing and progressing in Alzheimer's disease (AD) among individuals. Beyond genetics, recent studies highlight the critical role of lifestyle factors in enhancing CR and delaying cognitive decline. DNA methylation (DNAm), an epigenetic mechanism influenced by both genetic and environmental factors, including CR-related lifestyle factors, offers a promising pathway for understanding the biology of CR. We studied DNAm changes associated with the Resilience Index (RI), a composite measure of lifestyle factors, using blood samples from the Healthy Brain Initiative (HBI) cohort. After corrections for multiple comparisons, our analysis identified 19 CpGs and 24 differentially methylated regions significantly associated with the RI, adjusting for covariates age, sex, APOE ε4, and immune cell composition. The RI-associated methylation changes are significantly enriched in pathways related to lipid metabolism, synaptic plasticity, and neuroinflammation, and highlight the connection between cardiovascular health and cognitive function. By identifying RI-associated DNAm, our study provided an alternative approach to discovering future targets and treatment strategies for AD, complementary to the traditional approach of identifying disease-associated variants directly. Furthermore, we developed a Methylation-based Resilience Score (MRS) that successfully predicted future cognitive decline in an external dataset from the Alzheimer's Disease Neuroimaging Initiative (ADNI), even after accounting for age, sex, APOE ε4, years of education, baseline diagnosis, and baseline MMSE score. Our findings are particularly relevant for a better understanding of epigenetic architecture underlying cognitive resilience. Importantly, the significant association between baseline MRS and future cognitive decline demonstrated that DNAm could be a predictive marker for AD, laying the foundation for future studies on personalized AD prevention.
4D Printing of Hydrophobic API-Infused Alginate-Gelatin Porous Scaffolds Reinforced with TiO2 and β-TCP for Tissue Regeneration and Drug Delivery
Authors: Ramirez-Cedillo Erick , Urruela-Barrios Rodrigo , García-Avila Josué , Alvarez Alejandro J. , Ortega-Lara Wendy 
Published: November 2024

Abstract

Although scaffolds in tissue engineering and regenerative medicine have shown enhanced properties when loaded with pharmaceutical active ingredients (API), not many systematic methodologies have been developed allowing controllable loads and a low energy input, especially hydrophobic drugs. In this work, a novel approach to load 3D printed alginate/gelatin hydrogel scaffolds with a hydrophobic antiinflammatory is presented. The scaffold, made mainly of alginate biopolymer is non-toxic, biocompatible, and highly porous. Inside its porous structure, active pharmaceutical ingredients (API) can be easily loaded. Due to the alginate ease of gelation, microextrusion 3D printing was used to produce these hydrogels-based scaffolds. In addition to the API, TiO2 and beta-tricalcium phosphate (𝛽-TCP) were incorporated in the scaffold to create reinforced composite hydrogels. Rheological profiles of the emulsion-laden solutions before crosslinking were analyzed. FTIR, XRD, thermal analysis, and electron microscopy are used to measure porosity and analyze the ibuprofen crystal size. Mechanical properties of the hydrogels were also compared and analyzed against a reference hydrogel with just alginate/gelatin. Finally, drug release curves were developed. The results showed that the loaded composite hydrogels could be manufactured by 3D printing. The resulting crosslinked structures have a porosity from 25𝜇m to 50 𝜇m, and crystals of the API were formed inside those pores. Moreover, the composite hydrogels showed enhanced mechanical properties up to 65 MPa of elastic modulus. Drug delivery curves also showed dependence on the crystal size inside the porous structure. Overall, this approach enables the synthesis of a printable composite alginate solution, loaded with an API, and with adequate physical properties for tissue regeneration.
ЦЕННОСТИ УНИВЕРСИТЕТСКОЙ КУЛЬТУРЫСКВОЗЬ ПРИЗМУ ЧУВСТВ(по воспоминаниям воспитанников и профессоровИмператорского Харьковского университета)
Authors:  Ю.  Киселева 
Published: November 2024

Статья посвящена реконструкции ценностно-эмоционального репертуара университетской культуры на основе изучения мемуарного комплекса императорского Харьковского университета. Автор отстаивает тезис об органической связи ценностей и эмоций в мемуарном дискурсе. Характерные черты университетской культуры обуславливали специфические формы отбора и репрезентации эмоций в воспоминаниях, но в то же время эмоции играли ключевую роль в процессе формирования, сохранения и трансляции университетской культуры посредством мемуарного дис-курса. Делается вывод об оптимистическом характере культуры университетской корпорации в целом и необходимости осознанного использования ее ценностно-эмоционального потенциала.
The article is devoted to the reconstruction of the repertoire of values and emotions in university culture on the basis of analysing the body of memoir literature from the imperial Kharkov University. The author argues that there existed an organic relationship between values and emotions in the memoir discourse. On the one hand, the distinctive features of university culture were caused by specific forms of selecting and representing emotions in memoirs, but at the same time emotions played a seminal role in the process of formation, preservation and transmission of university culture through the memoir discourse. The author concludes that there existed an “optimistic imperative” in the culture of the university corporation as a whole and that its principles of employing values and emotions remain valid today.
ВИЛЬГЕЛЬМ ФОН ГУМБОЛЬДТ И БЕРЛИНСКИЙУНИВЕРСИТЕТ – НОВЫЙ ВЗГЛЯДНА ПРОИСХОЖДЕНИЕ «ГУМБОЛЬДТОВСКОГО МИФА»
Authors:  О.  Морозов 
Published: November 2024

В статье исследуются истоки «гумбольдтовского мифа». Автор опровергает сложившуюся в науке точку зрения, согласно которой миф возник во время празднований 100-летнего юбилея Берлинского университета в 1910 г., показывая, что она не подтверждается источниками. По мнению автора, «гумбольдтовский миф» возник до 1910 г. в сочинениях немецких философов и педагогов начала ХХ в. под влиянием записки Гумбольдта «О внутренней и внешней организации высших научных учреждений в Берлине». Юбилей же Берлинского университета следует считать только одним из способов фиксации и распространения мифа.
This article traces the origins of the Humboldt myth. It challenges the established view that the myth arose during the celebrations of the centenary of Berlin University in 1910, demonstrating that this view is not confirmed by sources. First, the article examines the speeches delivered by the participants in the 1910 jubilee celebrations and concludes that they could not have provided the basis for the Humboldt myth because they mention Humboldt no more frequently than the names of other prominent scientists, and the brief assessments of his activities are too vague to warrant judgements about his contribution to the development of higher education. Second, the article analyzes the works of German philosophers and educators of the early twentieth century and stresses that the sources of the Humboldt myth go back mainly to works written before 1910, had nothing to do with the centenary of Berlin University and were influenced by Humboldt’s note On the Internal and External Organization of the Higher Scientific Institutions in Berlin published in 1903. The article concludes that the traditional view of the origin of the Humboldt myth needs to be re-examined: the myth was born before 1910 and the centenary of Berlin University was only one channel for asserting and spreading it.
ЭМОЦИОНАЛЬНЫЙ РЕЖИМЭПОХИ ФОРСИРОВАННОЙ ИНДУСТРИАЛИЗАЦИИ(по материалам Магнитогорска)
Authors:  И.  Макарова 
Published: November 2024

В статье рассматривается эмоциональный режим, сформировавшийся в новом индустриальном центре в период форсированной индустриализации. История эмоций стала популярным направлением в мировой исторической науке, однако исследования в «эмоциональном ключе» преимущественно выстраиваются в широких хронологических и территориальных рамках. Автор предлагает конкретный пример изучения эмоционального сообщества на локальном материале и показывает, что мысли и чувства горожан стремились унифицировать в рамках концепции формирования «нового города», навязывая магнитогорцам определенный набор нормативных эмоций и официальных практик, а также выражающих их эмотивов, которые выступали опорой для существующего политического режима.
The article considers an emotional regime that developed in the new industrial center in the period of accelerated industrialization. Currently, the history of emotions is mainly oriented to extensive material from the point of view of the chronology and spatial extent. The author offers an example of the study of emotional communities at local material and believe,s which the thoughts and feelings of the citizens wanted to unify within the concept of formation of a "new city" and Magnitogorsk, impose a certain set of normative emotions and the official practices, as well as expressing their emotives, which acted as a support for an existing political regime.
БУРГУНДИЯ ПРОТИВ ФРАНЦИИРОЛЬ АКТОВОГО МАТЕРИАЛАВ КОНСТРУИРОВАНИИ ИДЕНТИЧНОСТИ
Authors: Е. Носова 
Published: November 2024

В статье анализируется несколько актов (акт о назначении рыцаря Луи Гаста на должность советника и камергера Карла, графа Шароле, будущего герцога Бургундского Карла Смелого; акт о пожаловании королем Франции Людовиком XI мемуаристу Филиппу де Коммину сеньорий Тальмон и прочих), которые позволяют дополнить сложившиеся в историографии на основе анализа нарративных источников представления о методах идеологического противостояния между Францией и Бургундским государством. Несмотря на то, что грамоты не содержат преамбул, в которых традиционно находили отражение политические концепции, они продолжают выполнять функцию формирования определенного взгляда на событие, которая в эпоху Нового времени перейдет к памфлетной литературе.
The article analyzes some acts (the act on the appointment of a knight Louis Gast as a councilor and chamberlain of Charles, Count of Charolais, the future Duke of Burgundy Charles the Bold, the act of granting the principality of Talmon and others to memoirist Philippes de Commines by the King of France Louis XI) that allow to complete the picture of identity construction existing in historiography based on the analysis of narrative sources. Despite the fact that the letters did not contain a preamble, which traditionally reflected the political concept, they retained the function of generating a certain view of the event, which would pass to the pamphlets in the Modern times.
ИСКУШЕНИЕ ТРАДИЦИЕЙ: САМОИДЕНТИФИКАЦИЯАВТОРОВ РАННИХ ДЕМОНОЛОГИЧЕСКИХ ТРАКТАТОВ
Authors:  Г.  Бакус 
Published: November 2024

Статья посвящена авторским стратегиям обоснования правомерности преследования за злонамеренное колдовство (maleficium) в демонологических трактатах конца XV в. – сочинениях Генриха Инститориса (Malleus Maleficarum, Der Nürnberger Hexenhammer) и Ульриха Молитора (De Laniis et Phitonices Mulieribus Teutonice Hexen vel vncholden). Созданные после скандала вокруг инквизиционного дознания Генриха Инститориса в Инсбруке, эти сочинения содержат интерпретации злонамеренного колдовства через отсылку к предшествующей книжной традиции. Описывая maleficium оба автора стремятся обозначить особый статус личного опыта в деле преследования ведьм, используя собственные сочинения для коммуникации со светскими и церковными властями.
The paper deals with justification strategies for the persecution witch in the late 15th century demonological treatises, such as Malleus Maleficarum, Der Nürnberger Hexenhammer by Heinrich Institoris and De Laniis et Phitonices Mulieribus Teutonice Hexen vel vncholden by Ulrich Molitor. Written after the Institoris’s scandal failure in Innsbruck witch trial, these books contained interpretations of the nature of harmful magic in connection with previous tradition of intellectual culture. Describing maleficium both authors tended to justify personal experience in the field of witch hunting and used their treatises as form of communication with secular and ecclesiastical authorities.
«ЭТНИЯ» И «НАЦИЯ» КАК КЛЮЧЕВЫЕ ПОНЯТИЯКОНЦЕПЦИИ ЭТНОСИМВОЛИЗМА
Authors:  С.  Кузнецова 
Published: November 2024

В статье рассматривается проблема связи между этническими сообществами прошлого и современными национальными идентичностями. Внимание уделено содержанию понятий «этния» и «нация» в концепции этносимволизма и их эволюции в контексте дискуссий о «естественном» и «сконструированном» или «инструментальном» характере наций.
The problem of relations between ethnic communities of the past and modern national identities is discussed. Definitions of "ethnie" and "nation" in the ethno-symbolist concept and their evolution in the context of discussions about the "natural" and "constructed" or "instrumental" character of nations are revealed.
Assessment of the germination potential of Myrtus communis (L.) based on seed size
Authors: Mansouri Lahouaria Mounia , Kheloufi Abdenour , Belatreche Rabah 
Published: November 2024

The woody fodder species Myrtus communis (L.) is commonly found in the forested areas of northeastern Algeria, thus helping to alleviate the goat husbandry shortage during the summer. This study aims to conserve the species and counteract its declining populations due to various biotic and abiotic factors. A specific objective of this study is to assess the correlation between seed size and germination vigor in M. communis, as well as emergence of seedlings. A sample of 15 M. communis individuals was selected, and 500 fruits were randomly collected in the vegetation of Jijel National Park (Jijel, northeast Algeria). One month after post-ripening, when fruit moisture content reached 25.2%, seeds were manually extracted from the fruits and categorized into three sizes (large, medium, and small). Then, 100 leaves, 100 intact fruits, and 100 seeds from each size category were measured and weighed. Various morphological characteristics were recorded, including leaf and fruit length and width, pulp weight, seed number, pulp-to-seed ratio, seed size, and moisture content. Seed germination and initial seedling growth were monitored weekly. Seeds of M. communis ranged in weight from 0.03 to 0.18 grams. In comparison with medium (1.5%) and small (0%) seeds, large seeds showed significantly higher germination rates (93%) after three weeks of sowing. Moreover, seedlings originating from large seeds grew vigorously, reaching a length of 10.9 cm. According to our findings, seed size in M. communis can affect seed germination and high-quality seedling establishment.
A Taxonomy and Archetypes of AI-Based Health Care Services: Qualitative Study
Authors: Blaß Marlene , Gimpel Henner , Karnebogen Philip 
Published: November 2024

Background
To cope with the enormous burdens placed on health care systems around the world, from the strains and stresses caused by longer life expectancy to the large-scale emergency relief actions required by pandemics like COVID-19, many health care companies have been using artificial intelligence (AI) to adapt their services. Nevertheless, conceptual insights into how AI has been transforming the health care sector are still few and far between. This study aims to provide an overarching structure with which to classify the various real-world phenomena. A clear and comprehensive taxonomy will provide consensus on AI-based health care service offerings and sharpen the view of their adoption in the health care sector.

Objective
The goal of this study is to identify the design characteristics of AI-based health care services.

Methods
We propose a multilayered taxonomy created in accordance with an established method of taxonomy development. In doing so, we applied 268 AI-based health care services, conducted a structured literature review, and then evaluated the resulting taxonomy. Finally, we performed a cluster analysis to identify the archetypes of AI-based health care services.

Results
We identified 4 critical perspectives: agents, data, AI, and health impact. Furthermore, a cluster analysis yielded 13 archetypes that demonstrate our taxonomy’s applicability.

Conclusions
This contribution to conceptual knowledge of AI-based health care services enables researchers as well as practitioners to analyze such services and improve their theory-led design.
A Prediction Model to Identify Clinically Relevant Medication Discrepancies at the Emergency Department (MED-REC Predictor): Development and Validation Study
Authors: Van De Sijpe Greet , Gijsen Matthias , Van der Linden Lorenz , Strouven Stephanie , Simons Eline , Martens Emily , Persan Nele , Grootaert Veerle , Foulon Veerle , Casteels Minne , Verelst Sandra , Vanbrabant Peter , De Winter Sabrina , Spriet Isabel 
Published: November 2024

Background
Many patients do not receive a comprehensive medication reconciliation, mostly owing to limited resources. We hence need an approach to identify those patients at the emergency department (ED) who are at increased risk for clinically relevant discrepancies.

Objective
The aim of our study was to develop and externally validate a prediction model to identify patients at risk for at least 1 clinically relevant medication discrepancy upon ED presentation.

Methods
A prospective, multicenter, observational study was conducted at the University Hospitals Leuven and General Hospital Sint-Jan Brugge-Oostende AV, Belgium. Medication histories were obtained from patients admitted to the ED between November 2017 and May 2022, and clinically relevant medication discrepancies were identified. Three distinct datasets were created for model development, temporal external validation, and geographic external validation. Multivariable logistic regression with backward stepwise selection was used to select the final model. The presence of at least 1 clinically relevant discrepancy was the dependent variable. The model was evaluated by measuring calibration, discrimination, classification, and net benefit.

Results
We included 824, 350, and 119 patients in the development, temporal validation, and geographic validation dataset, respectively. The final model contained 8 predictors, for example, age, residence before admission, number of drugs, and number of drugs of certain drug classes based on Anatomical Therapeutic Chemical coding. Temporal validation showed excellent calibration with a slope of 1.09 and an intercept of 0.18. Discrimination was moderate with a c-index (concordance index) of 0.67 (95% CI 0.61-0.73). In the geographic validation dataset, the calibration slope and intercept were 1.35 and 0.83, respectively, and the c-index was 0.68 (95% CI 0.58-0.78). The model showed net benefit over a range of clinically reasonable threshold probabilities and outperformed other selection criteria.

Conclusions
Our software-implemented prediction model shows moderate performance, outperforming random or typical selection criteria for medication reconciliation. Depending on available resources, the probability threshold can be customized to increase either the specificity or the sensitivity of the model.