bluuebunny/crossref_metadata_2025_split huggingface dataset:
N-terminal acetylation of transcription factor LIP induces immune therapy resistance via suppression of PD-L1 expression in non-small cell lung cancer
Authors: He Xiang , Liu Yongshuo , Gao Xing , Tang Feiyu , Tian Yuxi , Gong Siyuan , Shen Jia , Wang Aimin , Sun Lunquan , Wei Wensheng , Weng Liang 
Published: November 2024

BackgroundProgrammed death-1 (PD-1) checkpoint blockade has revolutionized cancer therapy, yet its clinical success is confined to a subset of patients, underscoring the urgent need to understand the molecular underpinnings of programmed cell death ligand 1 (PD-L1) expression to combat immunotherapy resistance.MethodsEmploying CRISPR/Cas9 screening, we identified key regulators of PD-L1 in non-small cell lung cancer (NSCLC) cells, focusing on the transcription factor CEBPB and its isoform liver-enriched inhibitory protein (LIP). Through chromatin immunoprecipitation (ChIP) and luciferase reporter assays, we explored the interaction between LIP and basic-helix-loop-helix E22 (BHLHE22) in controlling PD-L1 transcription. We also used immunofluorescence and NBD-CI assays to examine how N-terminal acetylation affects LIP’s subcellular localization. The impact of LIP on tumor growth was assessed via subcutaneous tumorigenicity assays, while immunohistochemistry and immunofluorescence were used to analyze LIP-induced alterations in the tumor immune microenvironment.ResultsOur research indicates that CEBPB, particularly its LIP isoform, significantly suppresses PD-L1 expression in NSCLC cells. This suppression is contingent on LIP’s N-terminal acetylation by the N-terminal acetyltransferase A complex, which facilitates LIP’s nuclear entry and interaction with BHLHE22. This interaction leads to the formation of a co-repressor complex at the PD-L1 promoter, effectively reducing PD-L1 expression and enhancing the tumor immune response.ConclusionsIdentifying CEBPB, especially the LIP isoform, as a pivotal regulator of PD-L1 expression sheds light on the mechanisms behind PD-1 blockade resistance in NSCLC. Our findings suggest that modulating LIP’s function or its molecular interactions might offer a novel approach to boosting the efficacy of immunotherapies.
NSAID exposure delays time-to-pregnancy in patients with spondyloarthritis: an analysis of the GR2 prospective cohort
Authors: Hamroun Sabrina , Couderc Marion , Flipo René-Marc , Sellam Jérémie , Richez Christophe , Dernis Emanuelle , Frazier Aline , Gossec Laure , Gervais Elisabeth , Marotte Hubert , Dunogeant Laetitia , Lukas Cédric , Deroux Alban , Guettrot-Imbert Gaëlle , Le Guern Véronique , Costedoat-Chalumeau Nathalie , Molto Anna 
Published: November 2024

BackgroundThe impact of disease activity and treatment on fertility outcomes in patients with spondyloarthritis (SpA) has been little explored. This study aimed to describe median time to pregnancy (TTP) in women with SpA and the factors influencing TTP in this population.MethodsThis prospective observational multicentre (63 centres) French cohort (GR2 study—NCT02450396) included consecutive women with a diagnosis of SpA (according to their rheumatologist) who wanted to become pregnant between 2015 and 2021. TTP (in months) was the main outcome criterion, prospectively calculated from the date of study inclusion to the date of conception. Data on demographics, disease characteristics, disease activity, severity and treatment were prospectively collected at inclusion and each year thereafter until pregnancy occurred. TTP and its associated factors were estimated by survival analysis (Shared Frailty Cox models), with a random centre effect and multiple imputation to address missing data.ResultsWe analysed 88 women included before conception. Among them, 56 (63.6%) became pregnant during follow-up. Median TTP was 16.1 (95% CI (12.2 to 25.3)) months. Mean preconceptional Bath Ankylosing Spondylitis Disease Activity Index at inclusion was 2.9 (±SD 2.1). Patients were treated with TNF inhibitors, non-steroidal anti-inflammatory drugs (NSAIDs), conventional synthetic disease-modifying antirheumatic drugs and glucocorticoids in 61 (69.3%), 23 (26.1%), 12 (13.6%) and 8 (9.1%) cases, respectively. The multivariate model found a significant association between TTP and age (HR) (per year) 1.22 95% CI (1.08 to 1.40); p<0.001) and the use of NSAIDs during preconception (HR 3.01 95% CI (2.15 to 3.85); p=0.01).ConclusionAge and NSAID use during preconception were significantly associated with a longer TTP, after adjustment for other confounding factors. These findings warrant caution in the use of NSAIDs in SpA patients trying to conceive.
Effects of employees living with an ‘arthritis’ on sickness absence and transitions out of employment: a comparative observational study in the UK
Authors: Whittaker William , Higgerson James , Eden Martin , Payne Katherine , Wilkie Ross , Verstappen Suzanne MM 
Published: November 2024

PurposeTo assess sickness absence and transitions from employment for employees with arthritis compared with employees without arthritis over time.MethodsWe use 10 waves of the UK Household Longitudinal Survey (2009–2019). The sample (n=38 928) comprises employees aged 50 years to state retirement age. Arthritis was self-reported and could refer to people with conditions under the umbrella term ‘inflammatory arthritis’ or osteoarthritis (hereafter ‘arthritis’). Weighted random-effects multivariable linear probability models were estimated for two employment-related measures (1) sickness absence and (2) transitions from employment to: (a) unemployment; (b) long-term sick; (c) early retirement. These were regressed against a variable for arthritis and confounding factors (age, socioeconomic job classification, employing sector, year and additional health conditions). Additional analyses examined an interaction between the variable arthritis and these factors to test whether the effect of arthritis differs between these groups.ResultsEmployees reporting having arthritis were more likely to have sickness absence (1.35 percentage points greater rate (95% CI (0.92, 1.78)) and to transition to long-term sick (0.79 percentage points (0.46, 1.13)) and early retirement (0.58 percentage points (0.05, 1.11)). No effect was found for transitions to unemployment. There was limited evidence that the effects of arthritis vary for employees in different socioeconomic classifications.ConclusionsEmployees living with arthritis have higher rates of sickness absence and greater rates of transitions from employment to long-term sick and early retirement. Further work could look at ways to quantify the implications for individuals, employers and the state and ways to alleviate the effects of living with arthritis on work participation.
A Preliminary Study of the Impact of Intensive Hand Therapy after Arthroscopic Partial Trapeziectomy with Suture-Button Suspensionplasty for Thumb Carpometacarpal Arthritis
Authors: YAMAWAKI Rie , NANKAKU Manabu , IKEGUCHI Ryosuke , MAEDA Akemi , NOGUCHI Takashi , MATSUDA Shuichi 
Published: November 2024

Background: Thumb carpometacarpal (CMC) arthritis is a painful and debilitating condition, which in severe cases may be treated by surgery. Previous studies have emphasised the importance of rehabilitation following surgery to achieve optimal results. This study aimed to investigate whether intensive hand therapy is effective in improving hand functions after arthroscopic partial trapeziectomy with suture-button (SB) suspensionplasty in patients with thumb CMC arthritis. Methods: This was a retrospective observational study that used non-randomised historical controls. Patients who underwent arthroscopic partial trapeziectomy with SB suspensionplasty were divided into two groups according to whether they had postoperative hand therapy or not (hand therapy group, n = 12; no hand therapy group, n = 11). CMC joint pain, range of motion (ROM), grip and pinch strength in the operative side and Quick Disability of the Arm, Shoulder and Hand (QuickDASH) score were compared before surgery and at the final follow-up for each group. Results: CMC joint pain, ROM and QuickDASH scores significantly improved following surgery, in both groups. Conversely, postoperative grip and pinch strength only increased significantly in the hand therapy group (grip strength: effect size = 0.36, pinch strength: effect size = 0.44). Conclusions: This study demonstrates that early-stage intensive hand therapy is an effective intervention after arthroscopic partial trapeziectomy with SB suspensionplasty, specifically for improving grip and pinch strength. Level of Evidence: Level III (Therapeutic)
Development vs. Rights
Authors: Florence P Sahana , Mishra Achyutananda 
Published: November 2024

Abstract
Human rights and environmental protections are often violated as a consequence of development activities. In addition to harming the environment, this increases the marginalisation of those who are already marginalised. The development paradigm that is based on the interests of the majority not only tends to retard the indigenous people but also renders them incapable of competing with the majority. For the indigenous people, development has always been a problem rather than a solution. Development initiatives under the umbrella of globalisation with a label of monotony, ignore the aspects of the diverse livelihoods of many indigenous peoples. The Niti Aayog proposed in its vision document, the Sustainable Development of Little Andaman, in 2021, that the island should be developed into a megacity by utilising its natural features and strategic location. The long-term objective is to develop the island into a major financial tourism hub that can rival Hong Kong and Singapore. This plan will, on the one hand, advance commerce, employment, and economic growth; on the other hand, environmental conservation issues will also arise. Concerns over this vision document have indeed been voiced by several academics, environmentalists, and conservationists due to issues with Onge indigenous rights, ecological fragility, and earthquake and tsunami susceptibility. In this context, the research article aims to study and analyse the proposed megacity project and its impact on the rights of Onge tribes and the environment.
China’s Research on China is Already Severely Self Semi-Colonialized
Authors: Huang Philip C. C. 
Published: November 2024

Abstract
In a global context, scholarly monographs occupy the most basic and important position in virtually all fields of scholarly endeavor, but China’s policy has been to discourage, even eliminate, the production of scholarly monographs, its intention being to make journal articles the fundamental literature in all fields of study. The result is that monographic studies of China have come to be dominated completely by foreign English-language works, with virtually no research by China’s own scholars. China needs urgently to emphasize once more weighty monographic studies of China in Chinese, to correct what amounts to a self-imposed colonialization of Chinese China studies.
Cross-Sectional Organizational-Level Survey Data on Civil Society Organizations in the Metropolitan Region of Vienna, Austria
Authors: Terzieva Berta , Maier Florentine , Meyer Michael , Burkart Christian 
Published: November 2024

Abstract
This article introduces a pioneering dataset from a survey of civil society organizations (cso s) in the metropolitan region of Vienna, Austria. The survey was conducted between October 2019 and December 2020 and provides a comprehensive overview of the current state of the civil society sector in Vienna. It comprises a representative sample of 358 cso s and an additional targeted sample of 235 large cso s. The anonymized dataset is stored at the Austrian Social Science Data Archive (aussda). It can be freely accessed after the end of the embargo period in May 2025. The survey includes more than 60 questions covering a wide range of topics, including organizational goals and activities, beneficiary and staff demographics, different forms of organizing and related practices, performance metrics, budgeting, funding sources, and collaborative efforts. The dataset is a valuable resource for scholars interested in studying the inner workings, relationships, and societal contributions of civil society organizations, and it appeals to a variety of scholarly debates.
Transhumanism, Disability, and Human Flourishing
Authors: Guo Rui 
Published: November 2024

Abstract
This paper examines radical enhancement and its presupposed concept of morphological freedom from the perspective of current disability studies, revealing the three basic tendencies of a transhumanist anthropology that overemphasizes human rationality, ignores bodiliness, and accentuates individualism, and pointing out that human flourishing is rooted in a pluralistic coexistence that embraces human vulnerability, which underpins the legal regulation of radical enhancement.
Perioperative Outcomes of Branchial Cleft Sinus Tract Excision in Pediatric Patients Without the Use of Intraoperative Dye
Authors: Habib Daniel R. S. , Jamal Naadir H. , Patel Kalpnaben , Wootten Christopher T. , Belcher Ryan H. 
Published: November 2024

Background: Branchial cleft cysts are pediatric congenital anomalies that can present as sinus tracts to the neck. Intraoperative methylene blue dye with fibrin glue has been suggested as an effective tool for tracking the tract’s depth to help definitively excise. In this large retrospective study of 118 patients spanning a decade, we aim to elucidate outcomes of branchial cleft anomaly excision without methylene blue dye. Methods: A retrospective review was conducted with patients who received branchial cleft anomaly (BCA) with sinus tract excision at Monroe Carrell Jr. Children’s Hospital from June 2012 to June 2022. We collected demographic variables, BCA characteristics, perioperative care variables (ie, prior drainage, imaging, and concurrent procedure), and perioperative outcomes (ie, intra- and post-operative complications). Median and interquartile range (IQR) were calculated for continuous demographic variables, and average and standard deviation (SD) were calculated for sinus tract length. Two-tailed Chi-square or Fisher’s exact tests were performed to compare categorical samples where applicable with a statistical significance threshold set a priori at P < .05, and multivariable logistic regression assessed significant associations. Results: The sample included 118 patients with an average tract length of 3.3 cm (SD = 1.7 cm). Incision/drainage was performed before definitive excision in 16 (13.6%) patients and was associated with age above the median (aOR = 5.29, 95% CI = 1.39-20.09, P = .015) and female sex (aOR = 3.81, 95% CI = 1.12-13.01, P = .032). Most patients (N = 85, 72.0%) did not receive imaging. Among 118 cases, 2 (1.7%) required return to the operating room for surgical site complications. No patients experienced intra-operative complications or tract recurrence necessitating revision surgery. Conclusion: Patients with branchial cleft sinus tracts that were surgically excised without intraoperative dye achieved definitive resection with no recurrence and limited post-operative complications. While not a direct comparison, these results suggest that using intraoperative dye may be associated with unnecessary costs without benefit in outcomes.
Approach to Different Features of Plastibell Ring Circumcision
Authors: Akhavizadegan Hamed , Afshar Kourosh , Aghamir Seyed Mohammad Kazem 
Published: November 2024

Introduction: In this review article, we aim to illustratively address abnormal and normal courses of Plastibell (a system designed to remove the correct amount of skin) circumcision. We searched 2 target databases, PubMed and Embase, for Plastibell ring circumcision and recruited photos from circumcised children with plasticbell rings. The ordinary postprocedure healing course may resemble abnormal situations such as infection and dehiscence. Conversely, adverse events are rarely noticed by parents. Thus, medical attention is sought when it is not needed and omitted when the specialist may require an intervention. Conclusion: Providing a pamphlet illustrating standard normal and abnormal features of plastic bell ring circumcision will decrease family stress, emergency referrals, and preventable complications in this standard procedure.
Let Alone to Listen: The Impact of Northern Territory Liquor Laws on Aboriginal Justice Outcomes
Authors: Negrine Joseph 
Published: November 2024

AbstractThis article tracks the development of liquor laws in the Northern Territory, considering their impacts on Aboriginal justice outcomes and possible areas for reform. Noting the putative trade-off between health and justice outcomes, it examines the Northern Territory National Emergency Response Act 2007 (Cth), the Stronger Futures in the Northern Territory Act 2012 (Cth) and the 2022–23 Liquor Act 2019 (NT) amendments. Under the most recent Liquor Act amendments, the sale, possession and consumption of alcohol remain restricted in prescribed areas, which must determine the future of their liquor laws by 28 February 2027. This article proposes that greater investment is required to support Aboriginal leadership throughout this decision-making process. Indeed, a central proposition of this article is that the failure to adequately consult Aboriginal communities has been a shared feature of all three laws, and a fundamental barrier to improving Aboriginal justice. Reflecting on the interaction between Aboriginal and non-Aboriginal legal systems, this article identifies issues in the current policies that risk replicating the shortcomings of previous laws, thereby failing to empower Aboriginal leadership or improve Aboriginal justice services.
The Regulation of Paid Parental Leave in Australia: Delivering Gendered Patterns of Care
Authors: Selvarajah Amanda Darshini 
Published: November 2024

AbstractKey changes to the Paid Parental Leave Act 2010 (Cth) (‘PPL Act’), which offers minimum wage payments to parents on parental leave, took effect in July 2023. These changes sought to improve the gender equal utilisation of parental leave. This article assesses these changes to that end. The article also explores the regulation of employer-funded parental leave policies, which has been under-researched to date, drawing upon recent Workplace Gender Equality Agency data and interviews with human resource professionals. The data reveals that employer-funded parental leave policies often provide higher levels of income replacement than the PPL Act but mirror many of the PPL Act’s features that discourage gender equal parenting. These findings highlight the need for further reform in the regulation of paid parental leave to increase take up amongst men. Such reform will require flexible parental leave policies with non-transferrable and generous entitlements for all parents with high levels of income replacement.
Ensuring Equitable Payment Options: A Legal Perspective on Banning ‘No Cash’ Policies in Australia
Authors: Chamorro-Courtland Christian 
Published: November 2024

AbstractThis article examines the legal case for banning ‘no cash’ policies at retailers in Australia, with a focus on fostering inclusivity for unbanked individuals and empowering consumers. The analysis explores three potential options for implementing such a prohibition: leveraging anti-discrimination laws, utilizing consumer protection laws or enacting new legislation. From a legal standpoint, the article argues that retailers should be mandated to accept cash when consumers seek to purchase essential goods and services. Drawing upon relevant legal frameworks, the article highlights the importance of protecting the rights of unbanked individuals and ensuring consumer choice. It explores the potential impacts on financial inclusion and consumer empowerment while considering the risks of financial crime. By delving into these considerations, this article aims to contribute to the ongoing discourse surrounding ‘no cash’ policies, offering insights and recommendations for policymakers and legal practitioners alike in their pursuit of a fair and inclusive society.
Mechanical versus bioprosthetic valve for aortic valve replacement in dialysis patients: Systematic review and individual patient data meta-analysis
Authors: Zoupas Ioannis , Loufopoulos Georgios , Tasoudis Panagiotis T. , Manaki Vasiliki , Namidis Iosif , Caranasos Thomas G. , Iliopoulos Dimitrios C. , Athanasiou Thanos 
Published: November 2024

ObjectiveThere is little evidence regarding the most beneficial choice between a mechanical and a bioprosthetic valve in the aortic position in dialysis patients. This meta-analysis compares the survival and freedom from reintervention rates between mechanical and bioprosthetic valves in patients on dialysis undergoing aortic valve replacement surgery.MethodsTwo databases were searched, and the systematic review was performed in accordance with the recommendations of the Preferred Reporting Items for Systematic Reviews and Meta-analyses statement. We conducted one-stage and two-stage meta-analysis with Kaplan–Meier-derived individual patient data and meta-analysis with random-effects model.ResultsEight studies were included, providing data about 1215 dialysis patients receiving mechanical valves and 1851 patients receiving bioprosthetic valves. During a mean follow-up of 43.1 months, overall survival rates were significantly improved in the mechanical valve group in comparison to the bioprosthetic one (hazard ratio [HR]: 0.76, 95% confidence interval [CI]: 0.69–0.84, p < 0.001). This was confirmed by the two-stage meta-analysis (HR: 0.72, 95% CI: 0.62–0.83, p = 0.00, I2= 17.79%). Regarding freedom from reintervention, no arm offered a statistically significant advantage, according to the two-stage generated analysis (HR: 1.025, 95% CI: 0.65–1.61, p = 0.914). Similarly, there was no evident superiority of a valve type for perioperative outcomes.ConclusionsMechanical valves are likely to be associated with a better survival outcome compared to bioprosthetic valves for patients on dialysis undergoing aortic valve replacement. However, freedom from reoperation rates and perioperative outcomes were comparable between the two valve types, with no arm exhibiting a statistically significant advantage.