bluuebunny/crossref_metadata_2025_split huggingface dataset:
Thickness‐Dependent Structural Stability and Anisotropy of Black Phosphorus
Authors: Li Qian , Huang Hao , Chen Zhongwei , Huang Xin , Deng Kerong , Luo Shuiping , Wang Zhongwu , Yu Xuefeng , Quan Zewei 
Published: January 2019

AbstractBlack phosphorus (BP) is emerging as a rising star in the post graphene nanomaterials, manifesting intriguing thickness‐dependent properties. However, there is little knowledge about the structural and mechanical stabilities of such BPs and their thickness dependence. Using high pressure technique, a comprehensive study was performed on the thickness‐dependent structural variations of BPs. It has been revealed from high pressure phase diagram that decrease of thickness enhances the structure stability of BPs, which is prominent between 71 and 13 nm. More importantly, an inhomogeneous distortion of the lamellar puckered structure is observed on these BPs, and the thinner ones exhibit enhanced anisotropic compressibility, with a rigid interlayer and zigzag structure and a relatively flexible armchair structure. This systematic study not only provides insights into thickness‐dependent structural nature of BPs but also lays foundation toward design and fabrication of BP‐based devices.
All‐Solid‐State Flexible Asymmetric Supercapacitors Fabricated by the Binder‐Free Hydrophilic Carbon Cloth@MnO2 and Hydrophilic Carbon Cloth@Polypyrrole Electrodes
Authors: Chen Zhiyuan , Zheng Luyao , Zhu Tao , Ma Zhihao , Yang Yongrui , Wei Chunding , Liu Lei , Gong Xiong 
Published: January 2019

AbstractSupercapacitors have attracted enormous attention for energy storage in both academic and industrial sectors in the past years. In this study, all‐solid‐state flexible asymmetric supercapacitors (ASCs) without any binder, incorporated with the hydrophilic carbon cloth (HCC) with MnO2 nanocomposite (HCC@MnO2) as the positive electrode, the HCC with polypyrrole (PPy) (HCC@PPy) as the negative electrode, and polyvinyl alcohol (PVA)–LiCl gel as both gel electrolyte and separator, are reported. The HCC@MnO2 and HCC@PPy electrodes are prepared by direct deposition of either MnO2 nanoparticles or PPy nanofilms on the HCC through a simple, facile, and controllable electrochemical deposition method, respectively. The HCC@MnO2 and HCC@PPy electrodes provide rich contact area for gel electrolyte, facilitating the rapid delivery of electrolyte ions, and also minimize the resistance of ASCs. As a result, all‐solid‐state flexible binder‐free HCC@MnO2//HCC@PPy ASCs exhibit a large operating voltage of 1.8 V, high energy density of 28.2 Wh kg−1 at the power density of 420.5 W kg−1, and excellent cycling stability (91.2% capacitance retention after 5000 cycles). The present study provides a facile, scalable, and efficient approach to fabricate all‐solid‐state ASCs with high electrochemical storage performance for flexible electronics.
Organic Memristor Utilizing Copper Phthalocyanine Nanowires with Infrared Response and Cation Regulating Properties
Authors: Lv Ziyu , Hu Qikun , Xu Zong‐Xiang , Wang Junjie , Chen Zhonghui , Wang Yan , Chen Meng , Zhou Kui , Zhou Ye , Han Su‐Ting 
Published: January 2019

AbstractCurrent organic memristive devices have been suffering from unstable performance, ambiguous mechanism, and poor NIR response, thus restricting their commercial translation. Here, a near‐infrared‐sensitive (NIR) organic memristive device with high stability based on solution‐processed copper phthalocyanine nanowires (N‐CuMe2Pc NWs) is first reported. Compared with uneven thermal evaporated N‐CuMe2Pc film, the N‐CuMe2Pc NWs film possesses a uniform 3D mesh structure, which attribute to the localized cationic migration, robust formation/rupture of conductive filament and subsequent improvement of reproducibility, thermal stability, and retention characteristics. Furthermore, operating voltage and OFF current can be readily regulated by NIR illumination due to strong NIR absorption of the well‐aligned edge‐to‐edge interconnected N‐CuMe2Pc NWs and tunable potential barrier formed between active layer and Ag electrode, which are further verified by absorption spectrum and Kelvin probe force microscope analysis, respectively. This study provides a generalized method for optimizing device performance and attaching phototunable properties of organic memristive memories. In addition, compared with pristine CuPc molecules with low solubility, limitation of thermal evaporation approach that is incompatible with scaling up is expected to overcome by the solution‐processed N‐CuMe2Pc NWs.
Highly Reversible and Rechargeable Safe Zn Batteries Based on a Triethyl Phosphate Electrolyte
Authors: Naveed Ahmad , Yang Huijun , Yang Jun , Nuli Yanna , Wang Jiulin 
Published: January 2019

AbstractZinc metal is an attractive anode material for next‐generation batteries. However, dendrite growth and limited Coulombic efficiency (CE) during cycling are the major roadblocks towards the widespread commercialization of batteries employing Zn anodes. In this work we report the novel adoption of triethyl phosphate (TEP) as a solvent and co‐solvent with aqueous electrolytes to obtain a highly stable and dendrite‐free Zn anode. Stable Zn plating/stripping for over 3000 h was obtained, accompanied by a CE of 99.68 %. SEM images of the Zn anodes revealed highly porous interconnected dendrite‐free Zn deposits. The electrolyte displayed good compatibility with both Zn anodes and potassium copper hexacyanoferrate (KCuHCf) cathodes for Zn ion batteries (ZIBs). The full cell showed a long cycling stability and high rate capability. The present work is a contribution towards cost‐effective and safe battery systems.
Synthesis of a bio‐based triazine derivative and its effects on flame retardancy of polypropylene composites
Authors: Ma Dong , Li Juan 
Published: January 2019

ABSTRACTA triazine derivative CC–Cy was synthesized using cytosine (Cy) and cyanuric chloride (CC). The CC–Cy was used as a charring agent and combined with ammonium polyphosphate (APP) to form an intumescent flame‐retardant (IFR) system. The IFR system was applied to improve the flame retardancy of polypropylene (PP). Moreover, bisphenol‐A bis(diphenyl phosphate) (BDP) was introduced in the IFR system to regulate the suitability between the IFR and PP. The results showed the PP containing 20 wt % APP and 5 wt % CC–Cy achieves the UL‐94 V‐2 rating. While the PP with 18 wt % APP/CC‐Cy (4:1) and 3 wt % BDP obtains the UL‐94 V‐0 rating indicating the improved flame‐retardant efficiency. Thermal degradation behaviors and char morphology both showed that the reactions between APP and CC–Cy promote the formation of char residues, and BDP works in gas phase to enhance the flame retardancy of PP composites. Thus, a synergistic IFR system based on APP, CC–Cy, and BDP is formed, which can protect PP from fire effectively. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2020, 137, 47367.
Asymmetric biphasic hydrophobic/hydrophilic poly(lactic acid)–polyvinyl alcohol meshes with moisture control and noncytotoxic effects for wound dressing applications
Authors: Ribba Laura , Tamayo Laura , Flores Marcos , Riveros Ana , Kogan Marcelo Javier , Cerda Enrique , Goyanes Silvia 
Published: January 2019

ABSTRACTA noncytotoxic film was developed in this work with asymmetric biphasic properties (hydrophilic/hydrophobic) that allow for gas exchange. Among its many biomedical applications, it could be applied as a wound dressing material where the absorption of exuded fluids and control of water loss is required simultaneously. Thin meshes were developed modifying one face of poly(lactic acid) (PLA) electrospun mats with polyvinyl alcohol (PVA) using a simple photografting methodology. The contact angle of the modified face of the film was 44° while that of the other face was the original value of 122°. The chemical modification was covalent, as confirmed by X‐ray photoelectron spectroscopy, stable over time and resistant to successive washing steps. Cytotoxic assays with fibroblast cells showed that PVA photo‐grafted onto PLA meshes present a high cell viability percentage. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 47369.
Metacognitive myopia and the overutilization of misleading advice
Authors: Fiedler Klaus , Hütter Mandy , Schott Malte , Kutzner Florian 
Published: January 2019

AbstractPrevious research on advice taking has explained the failure to exploit collective wisdom in terms of the egocentric underweighting of advice provided by independent others. The present research is concerned with an opposite and more radical source of irrational advice taking, namely, the failure to critically assess the validity of advice due to metacognitive myopia. Participants could use the advice of one or two experts when estimating health risks. They read sketches of the study samples that experts had drawn to estimate conditional probabilities (e.g., of HIV‐given drug addiction). Whether samples were valid or seriously biased, subsequent judgments were strongly affected by any advice (Experiment 1). Uncritical reliance on any advice persisted when participants were sensitized to the contrast of valid and invalid advice in a repeated measures design (Experiment 2), when participants themselves believed advice not to be valid (Experiment 3), and even after full debriefing about invalid advice (Experiment 4). Lay advice exerted a similar influence as expert advice (Experiment 5). Although these provocative results are independent of numeracy and consensus (Experiment 6), they highlight the impact of metacognitive myopia as an impediment of social rationality.
Fluorescence and absorption studies of DNA–Pd(II) complex interaction: Synthesis, spectroanalytical investigations and biological activities
Authors: Thakor Khyati P. , Lunagariya Miral V. , Bhatt Bhupesh S. , Patel Mohan N. 
Published: January 2019

AbstractNovel palladium(II) complexes (7a–7e) of substituted quinoline derivatives were synthesized. The complexes were characterized using various techniques such as thermogravimetric analysis (TGA), elemental analysis, conductance measurement, mass, absorption, infra‐red (IR), 1H NMR, 13C NMR and energy‐dispersive X‐ray spectroscopy (EDX). Complexes for herring sperm DNA (HS DNA) binding were explored and absorption titration and the binding constant (Kb) as well as Gibb's free energy were evaluated. Complex 7d exhibited the highest binding constant, therefore the thermodynamic parameters of 7d at different temperatures were evaluated. To support the results of the absorption titration, fluorescence titration, viscosity measurement and molecular docking studies were performed. The fluorescence quenching data as evaluated from Stern–Volmer equation were used to calculate KSV, Kf and the number of binding sites. The results of all these studies were in good agreement with the absorption study. DNA electrophoretic mobility was performed to explore the possible application of metal complexes as artificial metallonucleases. The antibacterial activity of the complexes was accessed against different pathogenic bacteria and cytotoxicity was measured using brine shrimp and S. pombe.
Acetyl Coenzyme A Analogues as Rationally Designed Inhibitors of Citrate Synthase
Authors: Bello Davide , Rubanu Maria Grazia , Bandaranayaka Nouchali , Götze Jan P. , Bühl Michael , O'Hagan David 
Published: January 2019

AbstractIn this study, we probed the inhibition of pig heart citrate synthase (E.C. 4.1.3.7) by synthesising seven analogues either designed to mimic the proposed enolate intermediate in this enzyme reaction or developed from historical inhibitors. The most potent inhibitor was fluorovinyl thioether 9 (Ki=4.3 μm), in which a fluorine replaces the oxygen atom of the enolate. A comparison of the potency of 9 with that of its non‐fluorinated vinyl thioether analogue 10 (Ki=68.3 μm) revealed a clear “fluorine effect” favouring 9 by an order of magnitude. The dethia analogues of 9 and 10 proved to be poor inhibitors. A methyl sulfoxide analogue was a moderate inhibitor (Ki=11.1 μm), thus suggesting hydrogen bonding interactions in the enolate site. Finally, E and Z propenoate thioether isomers were explored as conformationally constrained carboxylates, but these were not inhibitors. All compounds were prepared by the synthesis of the appropriate pantetheinyl diol and then assembly of the coenzyme A structure according to a three‐enzyme biotransformation protocol. A quantum mechanical study, modelling both inhibitors 9 and 10 into the active site indicated short CF⋅⋅⋅H contacts of ≈2.0 Å, consistent with fluorine making two stabilising hydrogen bonds, and mimicking an enolate rather than an enol intermediate. Computation also indicated that binding of 9 to citrate synthase increases the basicity of a key aspartic acid carboxylate, which becomes protonated.
A novel technique for coronary bifurcation intervention: Double rewire crush technique and its clinical outcomes after 2 years of follow‐up
Authors: Zhang Dong , He Yuan , Yan Ruohua , Yin Dong , Feng Lei , Xu Bo , Yang Yuejin , Zhu Chenggang , Dou Kefei 
Published: January 2019

AbstractObjectivesTo describe procedural details of the double rewire (DR) crush technique, a novel modified crush technique, and report the clinical outcomes of patients who underwent the procedure.BackgroundIn the management of complex bifurcation lesions, there is a need to use elective two‐stent techniques that stent the side branch (SB) before main vessel (MV) stenting and keep SB open.MethodsWe studied 48 patients with 49 bifurcation lesions who underwent percutaneous coronary intervention (PCI) using the DR‐crush technique between January and December 2013. Baseline, postprocedural, and follow‐up quantitative coronary angiographic analyses were performed. Procedural characteristics and clinical outcomes at follow‐up were assessed.ResultsMajority of the patients (60.4%, 29/48) had acute coronary syndrome. Most bifurcation lesions (77.6%, 38/49) were classified as Medina 1, 1, 1. Final kissing balloon inflation was successfully performed in all patients. After PCI, MV and SB of all patients had Thrombolysis In Myocardial Infarction 3 blood flow. None of the patients had MV or SB diameter stenosis ≥50% after PCI. At a mean follow‐up period of 2.4 years, target vessel revascularization occurred in 2.1% and myocardial infarction in 2.1%. No deaths occurred in this period.ConclusionsThe DR‐crush technique is feasible in coronary bifurcation stenting. Patients who underwent this procedure had relatively low incidence of adverse events. Larger studies are warranted for further confirmation of the findings.
Sulfur‐Rich Colloidal Nickel Sulfides as Bifunctional Catalyst for All‐Solid‐State, Flexible and Rechargeable Zn‐Air Batteries
Authors: Sumboja Afriyanti , Chen Jingwei , Ma Yuanyuan , Xu Yijie , Zong Yun , Lee Pooi See , Liu Zhaolin 
Published: January 2019

AbstractEarth‐abundant and high‐performance catalysts for oxygen evolution reaction (OER) and oxygen reduction reaction (ORR) are highly desirable in development of energy‐efficient rechargeable Zn‐air batteries. In this work, sulfur‐rich colloidal nickel sulfides (NiSx) are prepared as OER/ORR bifunctional catalysts via a two‐step hydrothermal process. The NiSx nanoparticles (NPs) with large surface area show high OER activity and excellent stability, as evidenced by low overpotential of 301 mV, small Tafel slope of 41 mV dec−1 and high stability over 20 h of chronopotentiometry test. Due to their sulfur‐rich nature (i. e. Ni3S4 and NiS2), the obtained NiSx also exhibit good ORR activity. The introduction of graphene oxide (GO) in the starting materials leads to the formation of a composite catalyst composed of conductive sulfur‐doped reduced graphene oxide (S‐rGO) and NiSx. A high ORR onset potential of 0.91 V (vs. RHE) is obtained from the sulfur‐rich NiSx NPs coupled with the S‐rGO which facilitates the electron‐transfer and furnishes the bifunctional catalytic activity. Rechargeable Zn‐air batteries with NiSx/S‐rGO bifunctional catalyst deliver stable charge and discharge voltages of 2.1 and 1.1 V over 590 cycles. Furthermore, all‐solid‐state and foldable Zn‐air batteries using pliable and robust air cathodes of NiSx/S‐rGO show similar voltage profile as their non‐foldable counterparts. The foldable batteries exhibit stable cycling performance for up to 120 discharge/charge cycles at either flat or folded state, proving their high electrochemical and mechanical stability.
Bioleaching von Rostasche der thermischen Abfallbehandlung im Jahreszyklus
Authors: Lewandowski Birgit , Knoll Thomas , Gärtner Tobias 
Published: January 2019

AbstractDas Recycling der Fraktion < 10 mm von Rostaschen der thermischen Abfallverwertung ist aus Gründen des Umweltschutzes zukünftig unumgänglich und zugleich ein Zugang zu Rohstoffen, die Deutschland bei der Versorgung unabhängiger machen können. Aufgrund der Inhomogenität von Rostaschen liefern Stichproben keine verlässlichen Gehaltsmittelwerte, weshalb nur eine Langzeitstudie mittels Rücklösung über das Potenzial Aufschluss gibt. Daher wird zur Einschätzung des Potenzials nicht die Konzentration der Rostasche herangezogen, sondern die Menge an Metallen (Al, Fe, Cu, Zn), die aus der Rostasche mittels Bioleaching gelöst werden kann.
Synthesis, Biological Evaluation, and Molecular Docking of Combretastatin and Colchicine Derivatives and their hCE1‐Activated Prodrugs as Antiviral Agents
Authors: Richter Michael , Boldescu Veaceslav , Graf Dominik , Streicher Felix , Dimoglo Anatoli , Bartenschlager Ralf , Klein Christian D. 
Published: January 2019

AbstractRecent studies indicate that tubulin can be a host factor for vector‐borne flaviviruses like dengue (DENV) and Zika (ZIKV), and inhibitors of tubulin polymerization such as colchicine have been demonstrated to decrease virus replication. However, toxicity limits the application of these compounds. Herein we report prodrugs based on combretastatin and colchicine derivatives that contain an ester cleavage site for human carboxylesterase, a highly abundant enzyme in monocytes and hepatocytes targeted by DENV. Relative to their parent compounds, the cytotoxicity of these prodrugs was reduced by several orders of magnitude. All synthesized prodrugs containing a leucine ester were hydrolyzed by the esterase in vitro. In contrast to previous reports, the phenylglycine esters were not cleaved by human carboxylesterase. The antiviral activity of combretastatin, colchicine, and selected prodrugs against DENV and ZIKV in cell culture was observed at low micromolar and sub‐micromolar concentrations. In addition, docking studies were performed to understand the binding mode of the studied compounds to tubulin.
Investigation of the Pentathiepin Functionality as an Inhibitor of Feline Immunodeficiency Virus (FIV) via a Potential Zinc Ejection Mechanism, as a Model for HIV Infection
Authors: Asquith Christopher R. M. , Laitinen Tuomo , Konstantinova Lidia S. , Tizzard Graham , Poso Antti , Rakitin Oleg A. , Hofmann‐Lehmann Regina , Hilton Stephen T. 
Published: January 2019

AbstractA small diverse library of pentathiepin derivatives were prepared to evaluate their efficacy against the nucleocapsid protein function of the feline immunodeficiency virus (FIV) as a model for HIV, using an in vitro cell culture approach. This study led to the development of nanomolar active compounds with low toxicity.
The concomitant use of tyrosine kinase inhibitors and proton pump inhibitors: Prevalence, predictors, and impact on survival and discontinuation of therapy in older adults with cancer
Authors: Sharma Manvi , Holmes Holly M. , Mehta Hemalkumar B. , Chen Hua , Aparasu Rajender R. , Shih Ya‐Chen T. , Giordano Sharon H. , Johnson Michael L. 
Published: January 2019

BackgroundThe concomitant use of tyrosine kinase inhibitors (TKIs) and proton pump inhibitors (PPIs) is a significant concern because of potential drug‐drug interaction that reduces TKI absorption, thus potentially reducing the effectiveness of TKIs. The objective of this study was to evaluate the prevalence and predictors of concomitant TKI‐PPI receipt and its impact on survival and therapy discontinuation in older adults with cancer.MethodsThis retrospective study used linked Surveillance, Epidemiology, and End Results‐Medicare data for the years 2007 through 2012. In total, 12,538 patients with lung cancer, renal cell cancer, chronic myelogenous leukemia, liver cancer, or pancreatic cancer were included. The primary exposure variable was concomitant receipt of TKI‐PPI, defined as at least 30 days of PPI use in the first 90 days from the start of the TKI (exposure period). The outcomes measured were overall survival and discontinuation of therapy in 90 days and 1 year after the end of the exposure period. Cox proportional‐hazards regression with inverse probability of treatment weighting was used to evaluate the association between exposure and outcome.ResultsThe overall prevalence of TKI‐PPI receipt was 22.7%. Predictors that were associated with increased use included polypharmacy and prior PPI receipt. TKI‐PPI use decreased survival in 90 days (hazard ratio, 1.16; 95% confidence interval, 1.05‐1.28) and in 1 year (hazard ratio, 1.10; 95% confidence interval, 1.04‐1.18) but was not associated with discontinuation.ConclusionsNearly 1 in 4 older adults with cancer who receive TKIs also receive PPIs concomitantly, and concomitant use is associated with an increased risk of death. Concerted efforts to manage medications are needed to identify and reduce the receipt of PPIs when TKIs are initiated.
No Effect of Plazomicin on the Pharmacokinetics of Metformin in Healthy Subjects
Authors: Choi Taylor , Komirenko Allison S. , Riddle Valerie , Kim Aryun , Dhuria Shyeilla V. 
Published: January 2019

AbstractPlazomicin is an aminoglycoside that was engineered to overcome aminoglycoside‐modifying enzymes, which are the most common aminoglycoside resistance mechanism in Enterobacteriaceae. Because plazomicin is predominantly eliminated via renal pathways, an in vitro study was conducted to determine whether plazomicin inhibits the organic cation transporter 2 (OCT2) and the multidrug and toxin extrusion (MATE1 and MATE2‐K) transporters, using metformin as a probe substrate. Plazomicin inhibited OCT2, MATE1, and MATE2‐K transporters with half‐maximal inhibition of the transporter values of 5120, 1300, and 338 µg/mL, respectively. To determine whether this in vitro inhibition translates in vivo, an open‐label, randomized, 2‐period, 2‐treatment crossover study (NCT03270553) was carried out in healthy subjects (N = 16), who received a single oral dose of metformin 850 mg alone and in combination with a single intravenous infusion of plazomicin 15 mg/kg. Geometric least‐squares mean ratios of the test treatment (combination) vs the reference treatment (metformin alone) and 90% confidence intervals were within the equivalence interval of 80% to 125% (peak plasma concentration, 104.5 [95.1–114.9]; area under the plasma concentration–time curve from time zero to time of last quantifiable concentration, 103.7 [93.5–115.0]; area under the plasma concentration–time curve from time zero to infinity, 104.0 [94.2–114.8]). The results demonstrate that there is no clinically significant drug‐drug interaction resulting from coadministration of single doses of intravenous plazomicin 15 mg/kg and oral metformin 850 mg in healthy subjects. Coadministration of plazomicin and metformin was well tolerated in healthy subjects.