bluuebunny/crossref_metadata_2025_split huggingface dataset:
Circulating miR-103a-3p and miR-660-5p are associated with bone parameters in patients with controlled acromegaly
Authors: Valassi Elena , García-Giralt Natalia , Malouf Jorge , Crespo Iris , Llauger Jaume , Díez-Pérez Adolfo , Webb Susan M 
Published: January 2019

Background
Biochemical control of GH/IGF-I excess in acromegaly (ACRO) is associated with persistent impairment of trabecular microstructure leading to increased risk of vertebral fractures. Circulating miRNAs modulate the activity of osteoblasts and osteoclasts, and may be potential biomarkers of osteoporosis.

Aims
Identify differentially expressed miRNAs in the serum of patients with controlled ACRO vs controls and correlate miRNA levels with both biochemical and structural bone parameters.

Patients and methods
Twenty-seven patients with controlled ACRO (11 males, 16 females; mean age, 48 ± 5 years; BMI, 28 ± 4 kg/m2) and 27 age-, gender- and BMI-matched controls were recruited. Areal BMD at lumbar spine and femur, and trabecular bone score were assessed; volumetric BMD was measured by quantitative computed tomography QCT-Pro (Mindways). Twenty miRNAs, chosen by their putative role in bone, were quantified in serum using real-time qPCR.

Results
In ACRO patients, miR-103a-3p and miR-191-5p were found overexpressed, whereas miR-660-5p was underexpressed (P < 0.001). miR-103a-3p levels were negatively associated with both trabecular vBMD at trochanter and serum osteoprotegerin concentrations (P < 0.05) and positively with vitamin D concentrations (P < 0.01) and total cross-sectional area of the femoral neck (P < 0.05). miR-660-5p levels were correlated with both trabecular vBMD at trochanter and OPG concentrations (P < 0.05), but were negatively associated with vitamin D levels (P < 0.05). A negative correlation between miR-103-a-3p and miR-660-5p was found in both groups (P < 0.001).

Conclusions
Circulating miR-103a-3p and miR-660-5p are differentially expressed in controlled ACRO patients and associated with bone structural parameters. miRNAs may be one of the mechanisms involved in the pathogenesis of bone disease and could be used as biomarkers in ACRO patients.
Parent-Adolescent Agreement About Adolescents’ Suicidal Thoughts
Authors: Jones Jason D. , Boyd Rhonda C. , Calkins Monica E. , Ahmed Annisa , Moore Tyler M. , Barzilay Ran , Benton Tami D. , Gur Raquel E. 
Published: January 2019

OBJECTIVES:
To examine agreement between parent and adolescent reports of adolescents’ suicidal thoughts and explore demographic and clinical factors associated with agreement in a large community sample.

METHODS:
Participants included 5137 adolescents 11 to 17 years old (52.1% girls; 43.0% racial minority) and a collateral informant (97.2% parent or stepparent) from the Philadelphia Neurodevelopmental Cohort. Families were recruited from a large pediatric health care network. Adolescents and parents completed a clinical interview that included questions about adolescents’ lifetime suicidal thoughts.

RESULTS:
Agreement was moderate for thoughts of killing self (κ = 0.466) and low for thoughts of death or dying (κ = 0.171). Discrepancies stemmed from both parental unawareness of suicidal thoughts reported by adolescents and adolescent denial of suicidal thoughts reported by parents. Fifty percent of parents were unaware of adolescents’ thoughts of killing themselves, and 75.6% of parents were unaware of adolescents’ recurrent thoughts of death. Forty-eight percent of adolescents denied thoughts of killing themselves, and 67.5% of adolescents denied thoughts of death reported by parents. Several demographic (eg, age) and clinical (eg, treatment history) characteristics were associated with agreement.

CONCLUSIONS:
Early identification and intervention hinge on reliable and valid assessment of suicide risk. The high prevalence of parental unawareness and adolescent denial of suicidal thoughts found in this study suggests that many adolescents at risk for suicide may go undetected. These findings have important clinical implications for pediatric settings, including the need for a multi-informant approach to suicide screening and a personalized approach to assessment based on empirically derived risk factors for unawareness and denial.
LISTS OF VOCATIONAL EDUCATION PROGRAMMES: STATUS AND POSSIBLE WAYS OF MODERNISATION
Authors: Blinov V. I. , Kurteeva L. N. , Sazonov B. A. 
Published: January 2019

Introduction. The liberalisation of state educational standards and the provision of greater autonomy for educational institutions in the formation of educational programmes indicate the need for development of a new classification system for Russian education, which should become common for all types of professional educational programmes, including additional training programmes.The aim of the publication was to discuss the status and possible ways to modernise the system of classification of educational programmes in Russian vocational education, taking into account the prospects of its development and the constant replenishment of the registers of professional standards and qualifications.Methodology and research methods. In the course of the study, a retrospective analysis of the development of the classification system of professional educational programmes was used, during which the best Russian and foreign practices were compared.Results. The features of the current lists of professions and specialties of secondary vocational education and areas of improvement in accordance with modern requirements of the system of classification of professional educational programmes used in these lists were considered. For updated lists, a new composition of enlarged groups of the classification system of vocational education programs has been proposed, coupled with a list of areas of professional activity of the register of professional standards of the Ministry of Labour of Russia. Scientific novelty. For the first time, it is proposed to refuse classifiers that are strictly tied to the lists of professions, specialties and training areas approved by the Ministry of Education and Science, which formally copy these lists. Combining the classification systems of vocational education programmes and areas of professional activity will allow an adequate comparison of statistical information on training in the education system with their actual use in the labour market.Practical significance. The introduction of the proposed classification system allows us more fully to take into account data on the training of specialists in the Russian system of vocational education, to reflect this data as accurately as possible in national and international educational statistics and to correlate them with employment indicators in various sectors of the economy and production.
Strategic Aspects of Intellectual Property Management in the Fashion Industry
Authors: Khvorostyanaya A. S. 
Published: January 2019

Purpose:in the present study, the author aims to analyze the strategic aspects of intellectual activity in the fashion industry and to develop recommendations for the formation of an intellectual property management system in this sector of the economy.Methods:the study is based on the use of a set of methods of theoretical and economic analysis, including analysis and synthesis, the method of description, the method of formal logic.Results:to achieve the purpose of the study, the author has solved the following tasks: 1) considered the key objects of intellectual property of the fashion industry, which are of strategic importance for the activities of companies in this field; 2) justified the strategic need for targeted management of intangible assets in the industry; 3) clarified the problem of intellectual property management and proposed recommendations for the formation of an appropriate strategic management system in the fashion industry.Conclusions and Relevance:it is very important for fashion industry companies to explore their competitive advantages for successful existence in the context of increasing international competition. Competitive advantages for this field of activity are mainly expressed in intangible assets. The main strategic objects of intellectual property of enterprises of the industry are commercial product, brand and technical innovations.The author analyzes the practices of companies in this sector of the economy in terms of situations involving to the use of objects of their intellectual property. It was revealed that the main strategic priority of managing the intellectual property of an enterprise today is the protection, preservation and development of intangible assets as a strategic resource needed to increase competitiveness, as well as the economic and information security of an enterprise. In this regard, the author proposed a strategic framework for building an intellectual property management system as a specific functional area of the centralized strategic management of the company. The study of the strategic aspects of intangible assets and the formation of the intellectual property management system is of scientific and practical interest for the development of effective strategies for the development of companies in the fashion industry.
Regional development programming
Authors: Komkov N. I. , Lazarev A. A. , Romantsov V. S. 
Published: January 2019

Purpose: the purpose of the article is to study the features of regional development in terms of the need to take them into account in the formation of development strategies. The revealed features are the level of development, potential, geographical location, etc. These features are displayed in the strategy of formation of development projects in the region.Methods: the methodological basis for the formation of prospects for the development of the region is the methodology of program-target management to solve the problems of development of complex hierarchical systems. The main elements of this methodology are the basis for programming development processes in the space "forecast-strategy-program-project".Results: the results of the study are to determine the stages of programming the sequence of regional development, finding ways and conditions for the transition between the stages and intermediate goals of development, the formation and selection of development projects. To overcome the contradictions in the formation of the composition of the objectives of the development of projects in a hierarchical system: “macro level – the level of regions – the level of municipalities”, the top priority rule is used over the following. There is also the possibility of adding a lower level of own goals and projects, in accordance with the interests of a particular region and municipality. The task of project selection is one of the most important. Its importance lies not only in the required and available financial resources, but also in shaping the structure of the objective function of each region, adequate to the development goals. Fragments of the scheme of programming of development of the Astrakhan region are given.Conclusions and Relevance: the current external conditions for the development of the domestic economy dictate the need for the full use of domestic resources and the capabilities of the scientific and technological potential to ensure the competitiveness of Russia. This implies a critical attitude towards the development prospects, which are formed without taking into account the national interests of our country. The complexity of strategy formation is due to the hierarchical structure of the country's economy and the difference in interests in the system “macro level – meso level – micro level”. The basis of the proposed approach to development programming is the formation of strategic forecasts. The authors proposed a sequence of actions for programming the formation and selection of development projects at the regional level, as well as a possible list of promising development goals for the region. The analysis of the peculiarities of the development of the regions showed their considerable heterogeneity, which is important to take into account when forming promising strategies. The proposed scheme for the formation of regional development strategies and the mathematical model of project selection are illustrated by the example of one of the municipalities of the Astrakhan region.
Contemporary Condition and Tendencies of the Civil Aviation's Development in Russia
Authors: Kaparulin D. L. 
Published: January 2019

Purpose:taking to attention exclusive role of air transport concerning necessity of providing the conditions for normal function of state economy and to satisfy the demands of population, the author put the purpose to analyze the modern condition of the Russian civil aviation development and to propose innovative arrangements in the field of modernization it's material-technical base future development and using.Methods:the author uses the system approach to perform this research; results of the scientific research of the other specialists in the problem; structure and function analysis; the theory of competitor's struggle for market; complex analyses of statistics and expert evaluations methods.Results:the system critical analyses of the modern condition of the Russian civil aviation material-technical base development is performed and innovative arrangements in the field of modernization Russian civil aviation material-technical base future development and using are proposed.Conclusions and Relevance:Russian civil aviation is the single one among all another universal types of transport reached growth of all basic technic-economical indexes for last several years. Due to keeping such positive tendencies and guaranteeing modernization Russian civil aviation material-technical base future development and using on the base of innovative technologies state assistance is necessary in the field of increasing taxes, fuel prices and rent fees for using main productive funds.
Tax Investment Incentives: Worldwide Experience and Russian Practice
Authors: Vyakina I. V. 
Published: January 2019

Purpose:the main purpose of the work is research of the applying foreign tax experience to stimulate investment in the Russian business environment, taking into account the special role of the tax system in the national economy, it can be as both a factor in creating threats of the economic security and a resource for its provision. To achieve this goal in the article you must accomplish the following tasks: to perform systematization and critical analysis of theories, empirical research and foreign experience in applying tax incentives to attract investments; to identify the features of the tax relations of the state and business and features of the use of tax incentives in the Russian business environment.Methods:methods of systematic, logical and comparative analysis of the scientific literature were used, an analysis of descriptive statistics was carried out taking into account the assessment of hierarchical and correlation dependencies between empirical data.Results:numerous empirical and theoretical studies on the effectiveness of tax incentives as a tool to increase the investment attractiveness of a territory contain extremely contradictory conclusions. The effectiveness of the application of tax benefits differs depending on the conditions of doing business in the jurisdiction. There is no consensus about the effectiveness of tax benefits, the findings of scientists differ depending on the countries and methods. However, despite numerous criticisms, tax incentives remain a popular policy tool for attracting investment in developed, transitional and developing countries.Conclusions and Relevance:tax relations are essentially multidimensional, complex, and their social, political and legal content is initially conflicting, which determines the need to find a balance between the interests of the state and business. The effectiveness of their practical application to attract investment in the Russian reality is increasing in combination with other non-tax factors, such as business conditions, infrastructure, management quality and institutional environment.
Influence of Bacteriophage Infections of Microbiota on the Expression of alpha-synuclein in the Rat Intestinal Wall
Authors: Sergeev V. G. , Tanaeva M. S. , Sergeeva T. N. , Chuchkov V. M. 
Published: January 2019

The aim of the study was to identify the effect of bacteriophage microbiota infection on the expression of alpha-synuclein (A-syn) in rat small intestinal wall cells.Material and methods. The work was performed on Wistar rats, which once a day rectally injected a cocktail of bacteriophages against pathogenic bacteria or sterile saline (control). Various parts of the small intestine were frozen on dry ice, and cryostat sections were prepared to immunohistochemically investigation the localization of A-syn in the cells of the intestinal wall after 10 days of experiment.Results. A significant quantitative increase of immunopositive to A-syn lymphocytes and an increase in the expression of this protein in the neurons of the intermuscular and submucous nerve plexuses were detected.Conclusion. Bacteriophage infection of the microbiota has a pronounced effect on the expression of alpha synuclein in lymphocytes and neurons localized in the wall of the small intestine.
Changes in thickness of cortex and its layers in the posterior lobe of the cerebellum in postnatal ontogenesis
Authors: Tsekhmistrenko T. A. , Klochkova S. V. , Mazloev A. B. , Nikityuk D. B. , Obukhov D. K. 
Published: January 2019

Objective– the study of age-related changes in the thickness of the cortex and its layers in the posterior lobe of the cerebellum of children.Material and methods.The work is performed on postmortem material (62 cerebellum), obtained from children aged from birth to 12 years who died as a result of injuries without brain damage. Using computer morphometry on the painted method Nissle frontal histological sections of cortex, taken in region right and left posterior quadrangular lobules (H VI) on top of the folia of cerebellum, was measured the cortical thickness and the thickness of molecular and granular layers. Analysis of quantitative data was performed at annual intervals.Results. The posterior lobe of the cerebellum the increase in the thickness of the cortex in the left hemisphere occurs in two stages: from birth to 1 year and then to 2 years, in the right hemisphere in three stages: from birth to 1 year, and 2 and 7 years. Right-sided asymmetry of the thickness of the cerebellar cortex observed in infants and children 7 years of age, thickness of granular layer in infants and children 9 years. Left-hand asymmetry is specific to cortical thickness and its molecular layer in children 12 months.Conclusion. The thickness of the cerebellar cortex and its layers in the area of the lobule H VI increases during early childhood, and in the right hemisphere also during the first childhood. Reducing the diameter of the cortex and layer in the posterior lobe of the cerebellum of children from birth to 12 years of age are not detected.
Overexpression of Semaphorin-3A and Semaphorin-4D in the Peripheral Blood from Newly Diagnosed Patients with Chronic Lymphocytic Leukemia
Authors: Parsa Somayeh , Sharifzadeh Sedigheh , Monabati Ahmad , Seyyedi Noorossadat , Ranjbaran Reza , Baghbani Mohammad Reza , Nemati Maryam , Jafarzadeh Abdollah 
Published: January 2019

Background: Semaphorins play prominent roles in physiological and pathological processes such as vascular development, tumor growth and immune responses. Semaphorins have different roles in various kinds of cancers, but there is no study concerning their expression in the chronic lymphocytic leukemia (CLL). This study aimed to assess the SEMA3A, SEMA4A and SEMA4D expression in patients with CLL.
Materials and Methods: Peripheral blood specimens were collected from 30 newly-diagnosed untreated patients with CLL and 30 healthy subjects as a control group. The SEMA3A, SEMA4A and SEMA4D expression was determined by real-time PCR method.
Results: The fold change expression of SEMA3A and SEMA4D was 7.58 ± 2.66 and 3.20 ± 0.99 in patients with CLL, and was 1.01 ± 0.31 and 1.00 ± 0.27 in healthy subjects, respectively. The CLL patients expressed higher amounts of SEMA3A and SEMA4D in comparison with healthy subjects (P<0.02 and P<0.03, respectively). The fold change expression of SEMA3A in patients with stage II (11.12 ± 5.35) was also higher than patients with stage I (4.49 ± 1.61, P<0.05). No significant difference was also observed in the expression of SEMA4A and SEMA4D between patients with stage I and stage II CLL. In both CLL and control groups, the fold change expression of SEMA3A was higher in men than in women (P<0.03 and P<0.02, respectively).
Conclusion: The results of the study indicated elevated expression of the SEMA3A and SEMA4D in patients with CLL. The SEMA3A expression was influenced by tumor stage and gender of participants.
Pengembangan Kurikulum Terintegrasi DI Sekolah/Madrasah
Authors: Rahman Khalid 
Published: January 2019

<span><em>The procedures and attributes are must fulfilled to integrated curriculum </em><span><em>development of schools or madrasah that consist: (1) the concept of </em><span><em>integrated curriculum development is conducted at SMAN 10 Malang, </em><span><em>consists of the integrated conception of vision and mission, institutional</em><br /><span><em>integration, the integration of curriculum and learning by models that </em><span><em>are suitable to within single disciplines, across several disciplines, and </em><span><em>inside the mind of the learner; (2) planning of integrated curriculum </em><span><em>that is used the rational-interaction model, and deductive rational model </em><span><em>to divide roles between the principal of school and the teachers, and to</em><br /><span><em>organize educational components that are supporting the integrated </em><span><em>curriculum development; (3) implementation for integrated curriculum </em><span><em>is carried out with the learning process in classroom, that prioritize the </em><span><em>methods of problem solving, project methods, teaching units, inquiry, </em><span><em>discovery, thematic approach, media of learning and sources of learning</em><br /><span><em>that are varied; (4) evaluation for integrated curriculum is conducted </em><span><em>with control function and supervision by the principal, while the teachers </em><span><em>assess students that is based on three domains, namely cognitive, affective </em><span><em>and psychomotor, then all of domains are manifested to form of test </em><span><em>instruments and non-test.</em><br /><span><strong>keywords: </strong><span><em>Curriculum Development, Integrated Curriculum</em></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span><br /><br class="Apple-interchange-newline" /></span></span>
Penyegaran Pendidikan Islam ; Wacana Redevinisi Dan Dekonstruksi
Authors: Fatahillah Faizal Rois 
Published: January 2019

<span><em>The Development of Islamic Education requires strong and detail </em><span><em>epistemology that can only be resulted from complete understanding </em><span><em>about classical inheritance about Islamic Education and then combined </em><span><em>with detail understanding about issue and challenge that faced by Islamic </em><span><em>Education at present and future. In this context, a scholar of Islamic</em><br /><span><em>education requires to know classical inheritance about Islamic Education </em><span><em>in his major well, and then mapping and searching the relevance to the </em><span><em>condition of Islamic Education at the present and future.</em><br /><span><strong>keywords: </strong><span><em>Islamic Education, Redivinisi, Deconstruction.</em></span></span></span></span></span></span></span></span><br /><br class="Apple-interchange-newline" /></span></span>