bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of growing environment on the antioxidant activity of recultivated pea seedlings (Pisum sativum L.)
Authors: Tsuruoka Yuki , Hosoya Takahiro 
Published: November 2024

AbstractPea seedlings (Pisum sativum L.) are young pea plants with the potential for sustainable cultivation; these plants are cost‐effective and provide high nutritional value. Although numerous studies have explored the nutritional content and functionality of pea seedlings, a few reports exist on the regrowth of pea seedlings after the initial harvest of their edible parts. Hence, this study aimed to elucidate the effect of the growing environment during recultivation on the properties and functionalities of pea seedlings. The non‐edible parts of commercially acquired pea seedlings were recultivated in three different environments: (1) indoors under sunlight during the day, (2) indoors with only artificial fluorescent light, and (3) in a dark room. The edible parts of the recultivated seedlings were extracted with methanol, and the antioxidant activities of the extracts were evaluated using the 2,2‐diphenyl‐1‐picrylhydrazyl radical scavenging assay. Plants grown in environment 1 exhibited the highest antioxidant activity. The antioxidant components of pea seedlings were identified to be kaempferol glycoside (1), quercetin glycoside (3), and their respective p‐coumaroyl acylated glycosides (2 and 4). This determination was made by separating the components via liquid chromatography–mass spectrometry using activity as an indicator. An analysis of these components across the studied environments revealed that the isolated quantities of components 2 and 4 were 2.7‐ and 6.2‐fold greater, respectively, from the plants recultivated in environment 1 than those recultivated in environment 2. This study highlights the importance of the recultivation environment on the production of plant functional components.
High‐flow nasal cannula for stabilisation of very premature infants: A prospective observational study
Authors: Jonáš Klára , Lamberská Tereza , Nguyen Truong An , Kudrna Petr , Plavka Richard 
Published: November 2024

AbstractAimTo assess the feasibility, safety and efficacy of using a high‐flow nasal cannula (HFNC) for stabilising very preterm infants after birth.MethodsA prospective observational study included preterm infants born at 28 + 0 to 31 + 6 weeks' gestation between February 2021 and December 2022 at the General University Hospital in Prague. Following delayed cord clamping, HFNC was administered at a flow rate of 8 L/min through the infants' nostrils. Criteria for switching to continuous positive airway pressure (CPAP) or positive pressure ventilation (PPV) included persistent bradycardia in the first few minutes or low saturation of oxygen (SpO2) after 5 min, respectively.ResultsOf the 65 infants enrolled in the study, 56 (86%) were successfully stabilised exclusively using HFNC while 7 (11%) required PPV. Additionally, 52 (80%) infants achieved SpO2 > 80% at 5 min, and 54 (83%) infants were successfully treated with HFNC within the first 3 h of life.ConclusionThe primary use of HFNC seems to be an appropriate alternative to CPAP for the stabilisation of very premature infants after birth and subsequent transfer to the NICU. A randomised trial comparing HFNC and CPAP in the delivery room will enable to answer the questions raised in this study.
A Nomogram for Predicting Recurrence in Stage I Non‐Small Cell Lung Cancer
Authors: Bian Rongrong , Zhao Feng , Peng Bo , Zhang Jin , Mao Qixing , Wang Lin , Chen Qiang 
Published: November 2024

ABSTRACTBackgroundEarly‐stage non–small cell lung cancer (NSCLC) is being diagnosed increasingly, and in 30% of diagnosed patients, recurrence will develop within 5 years. Thus, it is urgent to identify recurrence‐related markers to optimize the management of patient‐tailored therapeutics.MethodsThe eligible datasets were downloaded from TCGA and GEO. In the discovery phase, two algorithms, least absolute shrinkage and selector operation and support vector machine‐recursive feature elimination, were used to identify candidate genes. The recurrence‐associated signature was developed by penalized Cox regression. The nomogram was constructed and further tested via other independent cohorts.ResultsIn this retrospective study, 14 eligible datasets and 7 published signatures were included. A 13‐gene based signature was generated by penalized Cox regression categorized training cohort into high‐risk and low‐risk subgroups (HR = 8.873, 95% CI: 4.228–18.480 p < 0.001). Furthermore, a nomogram integrating the recurrence‐related signature, age, and histology was developed to predict the recurrence‐free survival in the training cohort, which performed well in the two external validation cohorts (concordance index: 0.737, 95% CI: 0.732–0.742, p < 0.001; 0.666, 95% CI: 0.650–0.682, p < 0.001; 0.651, 95% CI: 0.637–0.665, p < 0.001, respectively). The nomogram was further performed well in the Jiangsu cohort enrolled 163 patients (HR = 2.723, 95% CI: 1.526–4.859, p = 0.001). Post‐operative adjuvant therapy achieved evaluated disease‐free survival in high and intermediate risk groups (HR = 4.791, 95% CI: 1.081–21.231, p = 0.039).ConclusionsThe proposed nomogram is a promising tool for estimating recurrence‐free survival in stage I NSCLC, which might have tremendous value in management of early stage NSCLC and guiding adjuvant therapy strategies.
Lessons lost: Lack of requirements for post‐project evaluation and reporting is hindering evidence‐based conservation
Authors: Caruana Alex , Muir Matthew , White Thomas B. , Jones Julia P. G. 
Published: November 2024

AbstractFor conservation to be based on evidence, the outcomes of conservation actions need to be shared. The European Union (EU) is a major funder of conservation action in Europe through the well‐studied LIFE program. Less well‐known, but also funding substantial conservation action, is the European Regional Development Fund (ERDF). Through a systematic review of conservation projects funded by LIFE and ERDF, we identify substantial expenditure on biodiversity conservation (€1300 M and €760 M between 2014 and 2024 respectively). We explore the extent to which LIFE and ERDF contribute to building an evidence base about the effectiveness of conservation actions. There were differences between LIFE and ERDF in the extent to which documentation about the project was publicly available (89% and 26% respectively), and large differences in whether any form of project evaluation was available (63% and 5% respectively). A possible explanation for these results is differing funder requirements regarding the monitoring and reporting of project implementation and outcomes. We explore funder requirements across a sample of other conservation funders and suggest how changes could incentivize higher quality sharing of project outcomes. This would expand the evidence base needed to improve the effectiveness of conservation actions.
Development of soil spectroscopy models for the Western Highveld region, South Africa: Why do we need local data?
Authors: Kock Anru‐Louis , Ramphisa‐Nghondzweni Prudence Dimakatso , Van Zijl George 
Published: November 2024

AbstractThe increasing global demand for sustainable agriculture requires accurate and efficient soil analysis methods. Conventional laboratory techniques are often time‐consuming, costly and environmentally damaging. To address this challenge, we developed and validated locally calibrated mid‐infrared (MIR) spectroscopy models for predicting key soil properties pH, phosphorus (P) and exchangeable cations in soil samples from South Africa's Western Highveld region, using a dataset of 979 soil samples and machine learning algorithms Cubist, partial least squares regression (PLSR) and random forest (RF). A subset of spectra was also submitted to the newly developed Open Soil Spectral Library's (OSSL) prediction models to determine whether global prediction models could be used for local soil property prediction. Accurate predictions for pH, calcium (Ca) and magnesium (Mg), with coefficient of determination (R2) values exceeding 0.76 were obtained with the local calibration algorithms. The predictions for P, potassium (K) and sodium (Na) did not meet the requirements for reliability. Soil spectroscopic prediction models calibrated with local soils outperformed the corresponding global prediction models considered. The OSSL prediction results were inaccurate, with a RPIQ <1, and consistently underpredicted all soil properties. Furthermore, the OSSL collection of prediction models does not include a pH (KCl) model, the routinely used pH measurement method in South Africa. These findings highlight the importance of local calibration for accurate soil property prediction and underscore the need for regional representation in global spectral libraries. This research serves as the first local calibration of MIR spectroscopy models for the Western Highveld region of South Africa and provides a foundation for future local soil property inference model development. It also serves as a potential starting point for a comprehensive South African soil spectral library that can be contributed to global spectral libraries.
Comparison of metrics to reveal the role of soil fauna in soil health assessment in peat meadow restoration
Authors: Mioulet Charlie , Schrama Maarten , Berg Matty P. , Hannula S. Emilia 
Published: November 2024

AbstractUnderstanding the nuances of soil health is more important than ever to improve the quality and sustainability of agroecosystems. However, it is poorly understood how the variety of metrics currently in use to evaluate soil health relate to each other, and in what situations their use is not sensitive enough to indicate environmental changes. The use of faunal co‐occurrence networks is a novel, potentially valuable tool that has hitherto received little attention in the context of soil health. Here, we used a meadow land‐use intensity gradient to compare the response of a number of soil community metrics, including chemical and ecological indicators as well as faunal co‐occurrence network parameters. Our findings indicate that the examined metrics displayed distinct, often contrasting patterns to one another, and that network analysis detected patterns that strongly aligned with the land‐use effects. This pattern was qualitatively different from patterns arising from traditionally used metrics. The soils with conventional farming, that is, the least regenerative land‐use, generally scored well in traditionally used metrics, including C:N ratio, faunal abundance and the ratio of Acari to Collembola. Regenerative farming was comparable with conventional farming in all conventional metrics—however, network analysis revealed that the soil faunal communities under regenerative farming had the highest species connectivity out of all research areas potentially due to grazing increasing the connectivity of faunal networks. Overall, these results suggest that network analyses are best suited to capture subtle land‐use intensity differences while traditional metrics performed well in big changes. While more research is needed to better interpret soil faunal co‐occurrence networks, our findings imply that it could be a useful method to provide further insight in aspects of soil health.
The Potential for Experimental Evolution to Uncover Trade‐Offs Associated With Anthropogenic and Climate Change Adaptation
Authors: Griffiths Joanna S. , Sasaki Matthew , Neylan Isabelle P. , Kelly Morgan W. 
Published: November 2024

ABSTRACTEvolutionary responses to climate change may incur trade‐offs due to energetic constraints and mechanistic limitations, which are both influenced by environmental context. Adaptation to one stressor may result in life history trade‐offs, canalization of phenotypic plasticity, and the inability to tolerate other stressors, among other potential costs. While trade‐offs incurred during adaptation are difficult to detect in natural populations, experimental evolution can provide important insights by measuring correlated responses to selection as populations adapt to changing environments. However, studies testing for trade‐offs have generally lagged behind the growth in the use of experimental evolution in climate change studies. We argue that the important insights generated by the few studies that have tested for trade‐offs make a strong case for including these types of measurements in future studies of climate adaptation. For example, there is emerging consensus from experimental evolution studies that tolerance and tolerance plasticity trade‐offs are an often‐observed outcome of adaptation to anthropogenic change. In recent years, these types of studies have been strengthened by the use of sequencing of experimental populations, which provides promising new avenues for understanding the molecular mechanisms underlying observed phenotypic trade‐offs.
Frailty in kidney transplant recipients
Authors: Uchida Junji , Iwai Tomoaki , Machida Yuichi 
Published: November 2024

AbstractKidney transplantation is the treatment of choice even for the elderly, as it improves quality of life and life expectancy, lowering the financial burden to the health care system compared to dialysis therapy. In Japan, kidney transplant recipients have become older due to the shift in demographics. Compared to community‐dwelling elderly adults, elderly kidney transplant recipients undergoing immunosuppressive therapy have a higher risk of age‐related outcomes including hospital readmissions, infections, dementia, malignancies, and fractures. In frailty, patients become vulnerable to adverse events after stressors due to a lack of physiologic reserve. Although it is often associated with aging, frailty can also occur in younger individuals with certain chronic illnesses or conditions including chronic kidney disease. Limited compensatory mechanisms result in functional impairment and adverse health outcomes, such as disability, falls, decreased mobility, hospitalization, and death. Although kidney transplant recipients can restore their kidney function after transplantation, most of them still have chronic kidney disease, as well as a gradual decline in graft function as a result of chronic allograft nephropathy. Wait‐listed candidates for kidney transplantation with frailty are more likely to experience wait‐list removal or death. Frailty at the time of transplantation is associated with complications after kidney transplantation such as delayed graft function, longer hospital stays, rehospitalizations, immunosuppression intolerance, surgical complications, and death. Nevertheless, kidney transplantation can be a viable intervention for frailty in dialysis patients.
Relationships Among Growth Mindset, Turnover Tendency, Workplace Adaptability and Essentials of Magnetism of New Nurses: A Moderated Mediation Model
Authors: Xue Youru , Zhang Wei , Wang Jing , Zhu Yating , Li Dan , Sun Jingxian , Gao Li , Zhang Yanyan 
Published: November 2024

ABSTRACTAimsThe study objective was to examine the mediating and moderating effects of workplace adaptability and essentials of magnetism, respectively, on the relationship between having a growth mindset and turnover tendency among new Chinese nurses.DesignThis was a descriptive, cross‐sectional study.MethodsThe sample was selected through a multistage sampling method. A random sampling methodology was employed, with the selected regions comprising Heilongjiang, Beijing, Tianjin and Shandong Provinces. A total of 407 new nurses were selected from hospitals in these regions from March to May 2023 via convenience sampling. Multigroup path analysis was employed to test the mediating and moderating effects.ResultsHaving a growth mindset was negatively associated with turnover tendency and positively associated with workplace adaptability. Workplace adaptability had a negative effect on job turnover tendency. Essentials of magnetism had a moderating effect on the association between workplace adaptability and turnover tendency.ConclusionsWorkplace adaptability plays a mediating role in the relationship between having a growth mindset and turnover tendency. Essentials of magnetism play a moderating role in the relationship between workplace adaptability and turnover tendency. These findings provide some theoretical evidence that nursing managers can use to prevent turnover behaviour in new nurses.ImplicationsThe findings provide confirmatory support for the mediating and moderating effect of workplace adaptability and essentials of magnetism, respectively, on the relationship between having a growth mindset and turnover tendency among new Chinese nurses. Different measures are needed to reduce turnover tendencies to improve the growth mindset of nurses, adaptability and the hospital environment.Reporting MethodWe have adhered to the transparent reporting of evaluations with quantitative design statements and the corresponding checklist was followed.Patient or Public ContributionsNo patient or public involvement.
Nurses' Perceptions of Organisational Attractiveness and Related Factors in Health Care: A Mixed Methods Systematic Review
Authors: Karjalainen Kirsi , Makkonen Marjo , Kuha Suvi , Kanste Outi 
Published: November 2024

ABSTRACTAimTo identify and integrate the best evidence on nurses' perceptions of organisational attractiveness and related factors in health care.DesignA mixed methods systematic review.MethodsThe review followed the Joanna Briggs Institute Mixed Methods Systematic Review methodology and a convergent segregated approach which involved separate qualitative and quantitative syntheses followed by integration in a narrative form.Data SourcesA systematic search was conducted in August 2023 with no time or geographical limits in CINAHL, PubMed, Finnish database Medic, Scopus, ProQuest, Web of Science, MedNar and EBSCO databases. Studies published in English, Finnish and Swedish were included.ResultsEleven studies (three qualitative, eight quantitative) were identified and studied further. The results indicated that key themes of organisational attractiveness in health care were the dimensions of patient and professional work well‐being, opportunities for professional growth and the responsibilities of the organisation.ConclusionsPatient and work well‐being for nurses have a considerable effect on organisational attractiveness. Organisations play a notable role in enabling nurses' professional growth. Responsibilities of the organisation extend to higher political decision‐making as well as to managers of the healthcare organisations. Organisational attractiveness covers the entire organisation, its patients, professionals and managers. Enhancing multi‐professional cooperation, implementing effective management practices and branding of the organisation can contribute to increased organisational attractiveness.Implications for Practice and ResearchOrganisations should consider nurses' wishes, develop strategies to improve competencies, leverage social media to develop their brand, extend the orientation to all levels of the organisation and increase interdepartmental and external collaboration. Future research on organisational attractiveness is necessary in health care and the views of healthcare professionals on a wider scale.Reporting MethodThe Preferred Reporting Items for Systematic Reviews and Meta‐Analyses guidelines were used when reporting the results.Patient or Public ContributionThere was no patient or public contribution.Trial and Protocol RegistrationThe protocol was registered in the PROSPERO database of the National Institute of Health Research (CRD42023451680).
Long‐term effects of sirolimus treatment for slow‐flow vascular malformations: Real‐world evidence from the French observational multicentre SIROLO study
Authors: Maillet Cécilia , Boccara Olivia , Mallet Stéphanie , Bessis Didier , Labrèze Christine , Mary‐Prey Sorilla , Guibaud Laurent , Bisdorff Annouk , Dompmartin Anne , Mazereeuw‐Hautier Juliette , Chiaverini Christine , Hubiche Thomas , Bonniaud Bertille , Degrugillier‐Chopinet Caroline , Bursztejn Anne‐Claire , Aubert Hélène , Severino Maella , Leducq Sophie , Tardieu Mathilde , Joly Aline , Boulouis Grégoire , Le Touze Anne , Paré Arnaud , Tavernier Elsa , Maruani Annabel 
Published: November 2024

AbstractRationaleSirolimus is a treatment for slow‐flow vascular malformations (SFVMs). However, the long‐term management remains challenging.ObjectivesThe SIROLO study assessed the long‐term effects and real‐life management of oral sirolimus for SFVMs by investigating data from 15 French tertiary centres for vascular anomalies.MethodsParticipants were retrospectively included if they had a SFVM that was being/had been treated with sirolimus for at least 3 years in total. Data were collected on treatment goals when initiating sirolimus, investigator‐reported efficacy, safety, dosages and treatment withdrawal.ResultsThe cohort involved 67 patients with various SFVM entities (mean [±SD] age 19.6 ± 12.5 years, 35 children, 52.2%). We found a heterogeneity of predefined treatment goals, the most frequent being cessation of pain. The investigators considered that sirolimus had persistent efficacy for bleeding, ulceration and pain but only slight efficacy for reducing volume. It was reported to be well‐tolerated, although serious adverse events (mainly infections and also two ovarian cysts) were reported in 6 patients (9.0%) and required definitive sirolimus discontinuation for one. Overall, 11 patients (16.4%) had at least one temporary withdrawal period, leading to symptom recurrence and sirolimus resumption at a mean of 6.4 ± 9.6 months. The mean sirolimus concentration was 6.4 ± 3.7 ng/mL during the first 6 months and decreased over time (mean concentration during the last 6 months: 4.2 ± 3.2 ng/mL), probably to target the minimal efficient dosage. Eight patients (11.9%) switched to alpelisib because of insufficient efficacy of sirolimus.ConclusionThis real‐life study gives answers to frequent questions patients and parents ask before sirolimus initiation for SFVMs, such as persistence of efficacy over time, long‐term side effects and time to recurrence in case of withdrawal.
Frailty integration in medical specialties: Current evidence and suggested strategies from the Clin‐STAR frailty interest group
Authors: Singh Namrata , Faye Adam S. , Abidi Maheen Z. , Grant Shakira J. , DuMontier Clark , Iyer Anand S. , Jain Nelia , Kochar Bharati , Lieber Sarah B. , Litke Rachel , Loewenthal Julia V. , Masters Mary Clare , Nanna Michael G. , Robison Raele Donetha , Sattui Sebastian E. , Sheshadri Anoop , Shi Sandra M. , Sherman Andrea N. , Walston Jeremy D. , Wysham Katherine D. , Orkaby Ariela R. 
Published: November 2024

AbstractFrailty is a syndrome that can inform clinical treatments and interventions for older adults. Although implementation of frailty across medical subspecialties has the potential to improve care for the aging population, its uptake has been heterogenous. While frailty assessment is highly integrated into certain medical subspecialties, other subspecialties have only recently begun to consider frailty in the context of patient care. In order to advance the field of frailty‐informed care, we aim to detail what is known about frailty within the subspecialties of internal medicine. In doing so, we highlight cross‐disciplinary approaches that can enhance our understanding of frailty, focusing on ways to improve the implementation of frailty measures, as well as develop potential interventional strategies to mitigate frailty within these subspecialties. This has important implications for the clinical care of the aging population and can help guide future research.