bluuebunny/crossref_metadata_2025_split huggingface dataset:
Features and functioning of Data Abstraction Assistant, a software application for data abstraction during systematic reviews
Authors: Jap Jens , Saldanha Ian J. , Smith Bryant T. , Lau Joseph , Schmid Christopher H. , Li Tianjing ,   on behalf of the Data Abstraction Assistant Investigators
Published: October 2018

IntroductionDuring systematic reviews, data abstraction is labor‐ and time‐intensive and error‐prone. Existing data abstraction systems do not track specific locations and contexts of abstracted information. To address this limitation, we developed a software application, the Data Abstraction Assistant (DAA) and surveyed early users about their experience using DAA.Features of DAAWe designed DAA to encompass three essential features: (1) a platform for indicating the source of abstracted information, (2) compatibility with a variety of data abstraction systems, and (3) user‐friendliness.How DAA functionsDAA (1) converts source documents from PDF to HTML format (to enable tracking of source of abstracted information), (2) transmits the HTML to the data abstraction system, and (3) displays the HTML in an area adjacent to the data abstraction form in the data abstraction system. The data abstractor can mark locations on the HTML that DAA associates with items on the data abstraction form.Experiences of early users of DAAWhen we surveyed 52 early users of DAA, 83% reported that using DAA was either very or somewhat easy; 71% are very or somewhat likely to use DAA in the future; and 87% are very or somewhat likely to recommend that others use DAA in the future.DiscussionDAA, a user‐friendly software for linking abstracted data with their exact source, is likely to be a very useful tool in the toolbox of systematic reviewers. DAA facilitates verification of abstracted data and provides an audit trail that is crucial for reproducible research.
Trimeric Supra‐Amphiphile with Diverse Lamellar Self‐Assemblies
Authors: Li Jun , Li Hui , Wang Jie , Jiang Hongshi , Yao Chenzhong , Wang Gaofeng , Ma Huixuan , Shi Lijuan 
Published: October 2018

AbstractA new kind of trimeric supra‐amphiphile [M‐4‐M‐4‐M][DBS]3 that exhibits diverse self‐assembly behaviours was fabricated through ion exchange between linear tricationic imidazolium chloride ([M‐4‐M‐4‐M]Cl3) and sodium dodecyl benzene sulfonate (SDBS). Micelles are spontaneously transformed into unilamellar vesicles at a quite low concentration (1.5 mM), and then evolved to multilamellar vesicles and planar bilayers successively with a further increase in the concentration of [M‐4‐M‐4‐M][DBS]3 in the absence of any additives. The presence of π‐π stacking interactions has been proved to promote the lamellar arrangement of the supra‐amphiphile. With increasing temperatures, [M‐4‐M‐4‐M][DBS]3 exhibits interesting “clouding” and phase separation in the La phase, behaving like common nonionic surfactants. Chain‐like aggregates are formed in the bottom phase, which are probably induced by the hierarchical assembly of vesicles. This work provides useful insights into the role of weak interactions in the fabrication and self‐assembly of oligomeric supra‐amphiphiles, and paves a way to enrich the structures and functions of self‐assemblies.
Synthesis, Surface Properties, and Antibacterial Activity of Novel Ester‐Containing Cationic Silicone Surfactants and Their Utilization as Fabric‐Finishing Agents
Authors: Wei Yuan , Zheng Cheng , Zhang Zhenqiang , Zeng Zhaowen , Mao Taoyan , Long Shikang , Ling Hui 
Published: October 2018

AbstractIn this study, a series of cationic silicone surfactants SiQCnCl containing ester groups and double long‐chain alkyls (n = 9, 11, 13, 15, and 17) were synthesized by microwave irradiation and characterized using infrared Fourier transform (FTIR), 1H nuclear magnetic resonance (1H NMR), and thermogravimetric analysis (TGA). Surface activity and adsorption of these surfactants were investigated by measuring the equilibrium surface tension. The critical micelle concentration (CMC) decreased with increasing alkyl length of SiQCnCl at 25 °C and so did the corresponding surface tension at the CMC (γCMC). The aggregation behavior in aqueous solutions was also investigated systemically through transmission electron microscopy (TEM) and dynamic light scattering (DLS). Spherical or ellipsoidal‐like aggregates with diameters ranging from 300 to 900 nm were observed. It is also shown that the cationic silicone surfactants exhibit certain antibacterial properties against Staphylococcus aureus but slightly poor to Escherichia coli. The morphological structure of SiQC15Cl‐treated cotton fabrics was observed using scanning electron microscopy (SEM), which showed that the surface became neat and smooth. What is more, the finished cotton fabrics maintained some antibacterial properties with improved softness, which may provide a more comfortable and healthy lifestyle. This work may also be helpful to the design and application of functional cationic silicone surfactants.
DHA rich algae oil delivered by O/W or gelled emulsions: strategies to increase its bioaccessibility
Authors: Gayoso Lucía , Ansorena Diana , Astiasarán Iciar 
Published: October 2018

AbstractBACKGROUNDThe bioaccessibility of bioactive compounds for functional food deserves evaluation. An in vitro gastrointestinal digestion model was applied to provide information about the extent of lipid hydrolysis, oxidative stability and bioaccessibility of algae oil (42% of docosahexaenoic acid; DHA), comparing three lipid delivery systems: bulk oil, soy protein stabilized O/W emulsion and carrageenan gelled emulsion.RESULTSLipid digestion kinetics was slightly influenced by the delivery systems. Nevertheless, at the end of intestinal digestion, lipolysis in the three samples ranged between 49% and 52%, showing a partial oil digestion. Lipid oxidation, measured by malondialdehyde, was significantly lower (P < 0.01) in both emulsified oils after intestinal digestion compared to the bulk oil. Bioaccessibility of DHA was 58%, 71% and 84% for bulk oil, O/W emulsion and gelled emulsion, respectively.CONCLUSIONThese results suggest that both emulsified delivery systems used in the present study enhanced the solubilization of free fatty acids, in particular omega‐3 fatty acids, and therefore their potential intestinal absorption. © 2018 Society of Chemical Industry
Effects of dietary marigold extract on lutein content, yolk color and fatty acid profile of omega‐3 eggs
Authors: Grčević Manuela , Kralik Zlata , Kralik Gordana , Galović Olivera 
Published: October 2018

AbstractBACKGROUNDLutein is a plant pigment very important for eye health in humans. Its bioavailability in humans is better from egg yolk than from dietary supplements. The aim of this research was to determine the influence of lutein (marigold extract powder) supplemented to laying hens' feed rich in omega‐3 fatty acids on the content of lutein, fatty acid profile in egg yolks and yolk color. The diets that contained 5% of oils as a source of omega‐3 fatty acids were supplemented with 0, 1 and 2 g kg−1 of marigold powder.RESULTSThe best enrichment of eggs with lutein was achieved by supplementing 2 g marigold kg−1 of feed. Yolk color was significantly intensified (P < 0.001) by supplementing 1 g marigold kg−1 of feed. The content of total saturated fatty acids, monounsaturated fatty acids and n‐6 polyunsaturated fatty acids (PUFA) remained unchanged, whereas the content of total n‐3 PUFA (P = 0.017) and docosahexaenoic acid (P < 0.001) was higher in the group with 2 g marigold kg−1 of feed. This group also had the most favorable ratio of n‐6:n‐3 PUFA.CONCLUSIONResults of this research showed that addition of marigold powder to laying hens' feed significantly increased egg lutein content and yolk color, and altered the fatty acid profile in yolk. Eggs with increased lutein content and a favorable profile of fatty acids are a good source of these ingredients in human nutrition. © 2018 Society of Chemical Industry
Full‐color multi‐plane optical see‐through head‐mounted display for augmented reality applications
Authors: Liu Shuxin , Li Yan , Zhou Pengcheng , Chen Quanming , Li Sida , Liu Yueda , Wang Yunfeng , Su Yikai 
Published: October 2018

AbstractBased on fast‐response polymer‐stabilized liquid crystal scattering shutters, we designed a full‐color multi‐plane optical see‐through head‐mounted display for augmented reality applications. Red, green, and blue light‐emitting diodes (LEDs) are used to illuminate a digital micromirror device in time sequence to create a full‐color 3D scene. A quasi‐collimated image projection source, with a large depth of focus, was designed, in order to ensure sharp pictures projected on different polymer‐stabilized liquid crystal films at different depth. Our system provides high‐quality full‐color images with correct depth information and thus solves the accommodation–vergence conflict problem. A proof‐of‐concept binocular full‐color two‐plane optical see‐through head‐mounted display prototype is demonstrated.
Dynamic tongue reconstruction with innervated gracilis musculocutaneos flap after total glossectomy
Authors: Righini Stefano , Festa Bianca Maria , Bonanno Maria Chiara , Colombo Valeria , Luca Nicola 
Published: October 2018

ObjectiveAdvanced tongue cancer treated with total glossectomy with laryngeal preservation (TGLP) has a high risk of severe postoperative morbidity due to the loss of swallowing and articulation ability. The purpose of our work is to highlight the potential of the innervated gracilis musculocutaneous flap (IGMF) to permit a good quality of life in patients after undergoing this kind of surgery, particularly when associated with an adequate rehabilitation course.MethodsWe are presenting a cohort of 15 patients with T3 or T4 tongue cancer treated with TGLP and dynamic reconstruction with IGMF between 1998 and 2016. Functional outcome data were collected employing flexible endoscopic examination of swallowing, as well as swallowing and speech tests and questionnaires. Our reconstructive procedure was compared with different techniques described in the literature.ResultsIn 13 out of 15 patients, a positive functional outcome was recorded, defined as the achievement of an adequate swallowing and speech ability. In two patients, the lack of success was caused by the flap's necrosis and death from early pulmonary metastasis. Of 13 patients, 12 were still alive after 2 years. Ten patients regained an independent feeding by mouth for normal food, whereas three patients continued percutaneous endoscopic gastrotomy supplementation. After 40 months, all 13 patients displayed a moderately intelligible speech capability.ConclusionAlthough TGLP can have devastating morbid effects, an appropriate dynamic reconstruction—along with an adequate course of rehabilitation—can provide good swallowing and articulation outcomes, which permit a satisfactory long‐term quality of life.Level of Evidence4 Laryngoscope, 129:76–81, 2019
Objective and subjective hyposalivation after treatment for head and neck cancer: Long‐term outcomes
Authors: Likhterov Ilya , Ru Meng , Ganz Cindy , Urken Mark L. , Chai Raymond , Okay Devin , Liu Jerry , Stewart Robert , Culliney Bruce , Palacios Daisy , Lazarus Cathy L. 
Published: October 2018

Objectives/HypothesisThis study examined saliva weight over time and its association with diet and patient‐rated swallowing, dry mouth, sticky saliva, and dysgeusia quality of life in head and neck cancer (HNCA) patients treated with surgery plus adjuvant chemoradiotherapy (CRT), or primary CRT.Study DesignProspective cohort study in an outpatient HNCA center setting.MethodsPatients were seen pretreatment, and 1, 3, 6, 12, 24, and 36 + months post‐treatment. All had newly diagnosed oral, oropharynx, nasopharynx, larynx/hypopharynx cancer from 2010 to 2016 and were to undergo surgery + CRT or primary CRT. Stimulated saliva weight was assessed with the Saxon test. Diet, eating, dry mouth, and dysgeusia quality of life were assessed and correlated with saliva weight, treatment modality, and tumor site.ResultsSaliva weight decreased the most within the first 3 months across treatment groups, except for the surgery + CRT group, which continued to decline. Similar trends were seen by tumor site. Performance Status Scale (PSS) Normalcy of Diet and all quality‐of‐life scores declined following treatment. The European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Head and Neck‐35 (EORTC QLQ‐H&N35); Eating Assessment Tool (EAT‐10); M. D. Anderson Dysphagia Inventory (MDADI) Composite, Global, and subdomain scores; and PSS Diet were significantly correlated with saliva weight.ConclusionsSaliva weight worsened post‐treatment across groups and tumor site, with improvement by 36 + months. Saliva weight correlated with diet, eating quality of life and perception of dysgeusia across time points. Despite dose‐sparing intensity‐modulated radiation therapy, newer technologies are needed to preserve saliva production and maintain higher quality of life.Level of Evidence2b Laryngoscope, 128:2732–2739, 2018
Height is an independent risk factor for postintubation laryngeal injury
Authors: Katsantonis Nicolas‐George , Kabagambe Edmond K. , Wootten Christopher T. , Ely E. Wesley , Francis David O. , Gelbard Alexander 
Published: October 2018

Objectives/HypothesisIntubation is an essential component of intensive care, yet it does have potential complications. Posterior glottic stenosis (PGS) is among the most severe sequela. Risk factors are poorly understood. One hypothesis is that large endotracheal tubes (ETTs) in smaller airways may increase risk. Because tracheal diameter is proportional to height, we designed a case‐control study to evaluate the association between intensive care unit (ICU)‐patient height (proxy for tracheal diameter) and their risk of postintubation PGS.Study DesignRetrospective case‐control studyMethodsAmong patients who underwent intubation in an ICU at a single tertiary care medical center between 2001 and 2015, a convenience sample of all patients with confirmed PGS (cases) were enrolled. Cases were matched 1:1 by age, sex, and race with intubated non‐PGS controls chosen from the same population of ventilated patients. Data on height, weight, comorbidities, size of ETT, and duration of intubation were abstracted from the medical record. Multivariate models were used to test the association between patient height and risk of PGS development.ResultsIn all, 106 PGS cases (mean age 48.9 years, 50.7% female, 79.2% Caucasian) were identified; 77 met inclusion criteria. Compared to matched controls, cases were significantly shorter (mean 166 cm vs. 173 cm, P = .001). Height and PGS showed an inverse relationship in multivariate models. Specifically, odds of PGS decreased 9% (95% confidence interval: 0.01%‐16%) for each centimeter increase in height.ConclusionsShorter height is independently associated with increased odds of having PGS. Further work should consider whether height should be incorporated into ETT selection algorithms.Level of Evidence3b Laryngoscope, 128:2811–2814, 2018
A systematic review of simulated laryngotracheal reconstruction animal models
Authors: Milner Thomas D. , Okhovat Saleh , Clement William A. , Wynne David M. , Kunanandam Thushitha 
Published: October 2018

ObjectivesReview of the literature to identify practical, high‐fidelity, commercially available animal models for simulation training and surgical skills maintenance in laryngotracheal reconstruction (LTR).MethodsA systematic review of PubMed and Embase databases was conducted independently by two authors, according to Preferred Reporting Items for Systematic Reviews and Meta‐Analyses guidelines. Search terms included “laryngotracheal reconstruction,” “laryngotracheoplasty,” “pig and larynx,” “sheep and larynx,” and “rabbit and larynx.” Articles were then assessed, identifying model cost and availability, model validation, feasibility as a training tool, and verisimilitude to pediatric LTR.ResultsIn total, 79 articles were considered suitable for inclusion in the study, incorporating both in vitro and in vivo models. Models utilized included rabbit (n = 69), pig (n = 7), sheep (n = 1), and goat (n = 2). The rabbit model was similar in size to the neonate, but differences in laryngeal anatomy and cartilage texture made graft insertion difficult. The anatomy of the pig, sheep, and goat larynges more closely resembled the pediatric patient, allowing improved grafting, but corresponded more in size to that of an older child. Commercial availability of the pig and sheep was considered greatest, and was reflected in cost. None of the animal models identified in the literature have been validated as a simulation tool.ConclusionsThe rabbit, sheep and pig models seemed to demonstrate the greatest potential for use as advanced pediatric airway surgery simulation models, with the rabbit model being most utilized in the literature. However, as yet there have been no models formally validated as a simulation training tool. Laryngoscope, 129:235–243, 2019
Pediatric Rhinoplasty: A national surgical quality improvement program analysis
Authors: Kamil Rebecca J. , Roxbury Christopher , Boss Emily 
Published: October 2018

ObjectivesRhinoplasty is commonly performed in children with congenital anomalies and resultant nasal deformity causing airway obstruction. Little is known regarding patient factors or perioperative sequelae. We define demographic characteristics and perioperative complications for children undergoing rhinoplasty within a large national cohort.Study DesignRetrospective cohort study of children aged ≤ 18 years undergoing rhinoplasty utilizing data from the 2012 to 2015 American College of Surgeons National Surgery Quality Improvement Program‐Pediatric public use file.MethodsAll children who underwent rhinoplasty were identified. Postoperative complications were defined as 30‐day postoperative infection, unplanned readmission and reoperation, and death. Multivariate logistic regression was used to identify predictors of complications. Subgroup analysis was performed based on child age (age < 5 years vs. 5–13 years vs. ≥ 14 years).ResultsOf 1,378 children undergoing rhinoplasty, 21(1.52%) children experienced complications, with the most common being unplanned readmission. Younger children were more likely to experience complications (3.79% aged < 5 years vs. 0.66% aged ≥ 14 years; P = 0.001). Using multivariate logistic regression analysis, we observed a 61% decreased odds of complication with each age group (odds ratio 0.39, 95% confidence interval 0.19, 0.77; P = 0.007). Younger children were more likely to be male (56.2% male aged < 5 years vs. 46.6% male aged ≥ 14 years; P = 0.011), have developmental delay (11.7% aged < 5 years vs. 3.65% aged ≥ 14 years; P < 0.001), and have craniofacial abnormalities (73.2% aged < 5 years vs. 42.1% aged ≥ 14 years; P < 0.001).ConclusionChildren undergoing rhinoplasty experience few major complications, with the most common being unplanned readmission. Younger children are at greater risk and are more likely to be male with craniofacial abnormalities.Level of Evidence4 Laryngoscope, 129:494–499, 2019
Radiographic muscle invasion not a recurrence predictor in HPV‐associated oropharyngeal squamous cell carcinoma
Authors: Farzal Zainab , Du Eugenie , Yim Eunice , Mazul Angela , Zevallos Jose P. , Huang Benjamin Y. , Hackman Trevor G. 
Published: October 2018

ObjectiveTo determine whether muscle invasion evident on pretreatment imaging in p16 + oropharyngeal squamous cell carcinoma (OPSCC) correlates with recurrence.Study DesignRetrospective review.MethodsTwo‐hundred and seventy‐six patients with p16 + OPSCC treated at a tertiary referral center from 2003 to 2015 were analyzed. All scans were reviewed by a dedicated neuroradiologist with subspecialty expertise in head and neck imaging. Radiographic evidence of muscle invasion to the genioglossus, hyoglossus, medial pterygoid, and prevertebral muscles was analyzed. Local and regional recurrence rates were compared between the muscle invasion and no muscle invasion groups.ResultsOne hundred and ninety patients met inclusion criteria with adequate follow‐up data and pretreatment imaging. Patients were predominantly male (87.5% male) and smokers (65.6% smokers) with a mean age of 56.7 (standard deviation: 9.0 years). Most commonly invaded muscles in the muscle invasion group were hyoglossus (57.8%) and genioglossus (56.3%). There was no statistically significant difference in primary site or nodal recurrence between the combined group, including definite or possible muscle invasion and the group without muscle invasion (P = 0.205 and P = 0.569, respectively). Additionally, no statistically significant difference was present in recurrence‐free and disease‐specific survival between the two groups at 3‐ and 5‐year follow‐up (P > 0.05).ConclusionRadiographic evidence of muscle invasion does not appear to be a predictor of human papilloma virus (+) OPSCC recurrence. Additional studies are needed to validate our findings.Level of Evidence4 Laryngoscope, 129:871–876, 2019
Office‐based laryngology: Technical and visual optimization by patient‐positioning maneuvers
Authors: Ghodke Ameer , Farquhar Douglas R. , Buckmire Robert A. , Shah Rupali N. 
Published: October 2018

Objective/HypothesisTo qualitatively and quantitatively assess the effect of discrete head postures/maneuvers during flexible laryngoscopy on visualization of specific anatomical structures within the laryngopharynx.Study DesignProspective, observational study.MethodsFlexible laryngoscopy was performed on 18 sequential patients. Videos of the laryngopharynx were captured during the neutral head position and five discrete maneuvers: maximal sniffing, head extension, right turn, left turn, and chin down. Images were analyzed using ImageJ, and differences in the (normalized) anatomical areas of interest were examined with each maneuver (paired t test]. Covariates for surgeon, nostril, and gender were evaluated.ResultsThere was a significantly increased (P = 0.009) area of view of the anterior space (petiole of epiglottis/anterior laryngeal vestibule) with head extension. Right head turn led to a significantly increased view of the left pyriform sinus (P = 0.00001), whereas left head turn yielded an increased view of the right pyriform sinus (P = 0.0001). The right and left vocal fold/ventricle were better visualized during right head turn (with the scope traversing the right nostril) and left head turn (with the scope traversing the left nostril), respectively. Chin‐down posture achieved a more distal view of the airway more frequently than the other maneuvers.ConclusionThe anterior space (supraglottic larynx) may be best visualized and accessed with head extension. Right and left head turn improve visualization of the contralateral piriform sinus. Chin down provides improved airway visualization in a plurality of patients. Future studies examining maneuvers are warranted to create a catalog of validated techniques to optimize the efficacy of the office‐based proceduralist.Level of Evidence2 Laryngoscope, 129:330–334, 2019