bluuebunny/crossref_metadata_2025_split huggingface dataset:
Glutathione Effects on Liver Enzymes and Serum Electrolyte in Mice Exposed to 850–1900 MHz Mobile Phone Radiation
Authors: BINHAMBALI ABDULHAKEEM 
Published: December 2024

Abstract

Background
The widespread presence of electromagnetic fields (EMF) produced by modern technologies may pose a significant threat to animal health. Ionizing radiation, a byproduct of EMF exposure, has the potential to contribute to serious diseases, including cancer. This study examines the impact of chronic exposure to 900-1800 MHz GSM-EMF-induced electromagnetic radiation on liver enzymes and serum electrolytes in mice, and the potential mitigating effects of exogenous glutathione (GSH) administration. Thirty-five adult male mice were randomly divided into seven groups and exposed to various modes of mobile phone radiation for five weeks, with or without GSH administration. Liver enzymes, Alkaline phosphates (ALP), Alanine transaminase (ALT) , Aspartate aminotransferase (AST) and, serum electrolytes, sodium, potassium and bicarbonate were analyzed.
Result
Results showed significant increases in ALP levels in the Silent, Ringtone + GSH, and Silent + GSH groups compared to control group, while ALT and AST levels remained largely unchanged with the exception of some groups across the experimental cohorts. Serum electrolyte concentrations did not significantly differ across the control group. Our study found that chronic mobile phone radiation exposure in mice generally does not significantly affect liver enzyme levels or serum electrolyte concentrations. However, certain combinations with GSH administration notably increased some biochemical markers like ALP, ALT, and AST levels.
Conclusions
Our study concluded that chronic mobile phone radiation had no significant impact on liver enzymes or serum electrolytes in mice. However, glutathione administration in combination with radiation increased liver enzyme levels, suggesting a potential role in oxidative stress mitigation. Further research is needed to explore these findings.
Evaluating Financial Performance of Commercial Banks Applying CAMEL Model: Evidence From Private Commercial Banks of Ethiopia
Authors: Yimer Mitku Malede 
Published: December 2024

Abstract

The study were mainly aimed to evaluated the financial performance of six purposely selected private commercial banks of Ethiopia for the period 2014-2018 applying camel model. Secondary data had been sourced from annual reports of these considered private banks. finding of the study reveal that, leverage ratio correlated significantly & negatively with capital to assets ratio (financial performance). In this regard, private commercial banks of Ethiopia found as highly leveraged but sound liquidity position. What is more, the study showed that, capital adequacy, asset quality, earning ability and managerial efficiency had no impact on private commercial banks’ financial performance. On the other hand, the liquidity position of these banks were found to be significant variable. More over, this study indicated that, selected banks financial performance found as healthy for the period a study considered. Finally, a researcher suggest, the findings of this study shall be helpful to the management of selected banks in making appropriate managerial decisions.
I-SVVS: Integrative stochastic variational variable selection to explore joint patterns of multi-omics microbiome data
Authors: Dang Tung , Fuji Yushiro , Kumaishi Kie , Usui Erika , Kobori Shungo , Sato Takumi , Toda Yusuke , Sakurai Kengo , Yamasaki Yuji , Tsujimoto Hisashi , Hirai Masami Yokota , Ichihashi Yasunori , Iwata Hiroyoshi 
Published: December 2024

Abstract

High-dimensional multi-omics microbiome data plays an important role in elucidating microbial communities’ interactions with their hosts and environment in critical diseases and ecological changes. Although Bayesian clustering methods have recently been used for the integrated analysis of multi-omics data, no method designed to analyze multi-omics microbiome data has been proposed. In this study, we propose a novel framework called integrative stochastic variational variable selection (I-SVVS), which is an extension of stochastic variational variable selection for high-dimensional microbiome data. The I-SVVS approach addresses a specific Bayesian mixture model for each type of omics data, such as an infinite Dirichlet multinomial mixture model for microbiome data and an infinite Gaussian mixture model for metabolomic data. This approach is expected to reduce the computational time of the clustering process and improve the accuracy of the clustering results. Additionally, I-SVVS identifies a critical set of representative variables in multi-omics microbiome data. Three datasets from soybean, mice, and humans (each set integrated microbiome and metabolome) were used to demonstrate the potential of I-SVVS. The results indicate that I-SVVS achieved improved accuracy and faster computation compared to existing methods across all test datasets. It effectively identified key microbiome species and metabolites characterizing each cluster. For instance, the computational analysis of soybean dataset, including 377 samples with 16,943 microbiome species and 265 metabolome features, was completed in 2.18 hours using I-SVVS, compared to 2.35 days with Clusternomics and 1.12 days with iClusterPlus. The software for this analysis, written in Python, is freely available at https://github.com/tungtokyo1108/I-SVVS.
Optimizing the operation of series and parallel reservoirs using the neutrosophic environment: A case study of the Karun watershed
Authors: Rezai Seyyed Ebrahim , Sharafati Ahmad , Edalatpanah Seyyed Ahmad , Jamali Saeed 
Published: December 2024

ABSTRACT
In this paper, neutrosophic inference is used for the first time as a new Fuzzy Set Theory generalization to improve the operation of series and parallel dam reservoirs. A case study was conducted on the problem of parallel and series use of multiple and multi-purpose reservoirs in the dams of the Karun watershed (Iran). The problem of optimizing the operations of dam reservoirs with the objective function of minimizing the shortages and maximizing the production of hydropower is modeled and solved using training data. The optimization results are applied to model the problem in ANFIS, the behavior of the system in the Neutrosophic environment is infered by ANFIS. Finally, the conventional operation method, and the ANFIS method was compared with Neutrosophic inference by Fuzzy performance criteria. The results showed that the proposed neutrosophic inference model can highly infer dam reservoir system behavior. This method has achieved higher fuzzy reliability, higher fuzzy resilience, and lower fuzzy vulnerability indices, resulting in higher fuzzy sustainability. It has improved the objective functions by 80 and 40 percent in the training data and by 67 and 36 percent in the test data, respectively, compared to the Operation Rule Curve and ANFIS.
Assessment of in vitro dynamics of pathogenic environmental Acanthamoeba T4 and T9 genotypes isolated from three recreational lakes in Klang Valley, Malaysia over the HaCaT cell monolayer
Authors: Halim Rohaya Abdul , Halim Hasseri , Hussain Rosnani Hanim Mohd , Aazmi Shafiq , Khan Naveed Ahmed , Siddiqui Ruqaiyyah , Anuar Tengku Shahrul 
Published: December 2024

ABSTRACT

Free-living amoebae of the genus Acanthamoeba are causative agents of keratitis and amoebic encephalitis. They are widely found in various ecological environments. Therefore, the present study brings results that can help to better understand the genotypes of the environmental isolates and their pathogenicity. This study procured 26 Acanthamoeba isolates from three recreational lakes in 2022. Polymerase chain reaction amplification was performed on positive Acanthamoeba samples. The thermotolerance, osmotolerance, and cytopathogenicity in human keratinocyte (HaCaT) cells of the samples were also evaluated. The phylogenetic analysis demonstrated that 12 isolates were of genotype T4, two (T9), six (T17), four (T8), and one each from T5 and T11. The thermo- and osmotolerance assays indicated that eight Acanthamoeba samples were potentially pathogenic. Two T4 and one T9 genotype also recorded 33-, 42-, and 133-kDa serine-type proteases, respectively. The HaCaT cell monolayer revealed that three T4 and one T9 samples achieved cytopathic effects within the 50–100% range, hence significantly cytotoxic. The lactate dehydrogenase secretion results demonstrated that three (T4) and one (T9) sample exhibited exceptional toxicity (over 40%) compared to the other samples. The responses of Acanthamoeba members with similar genotypes to pathogenicity indicator assays varied considerably, rendering correlation of pathogenicity with specific genotypes challenging.
Początki psychologii prenatalnej. Stanislav Grof i jego matryce perinatalne – przejaw geniuszu czy manowce nauki?
Authors: Lichtenberg-Kokoszka Emilia 
Published: December 2024

Stanislav Grof i jego koncepcje niemal nieznane w Polsce, na świecie cieszą się sporą, choć niejednoznaczną, sławą. Jako jeden z pionierów psychologii prenatalnej, a równocześnie współtwórca psychologii transpersonalnej, lekarz, psychiatra i terapeuta, łączy on w swoich teoriach elementy biograficzne z mistycznymi i transpersonalnymi. Niniejszy artykuł stanowi próbę przybliżenia stworzonej przez niego koncepcji matryc perinatalnych oraz kontrowersji powstałych wokół jego teorii. Działanie takie wydaje się zasadne zwłaszcza w kontekście tego, że koncepcje Grofa często stanowią podstawę kolejnych teorii oraz metod terapeutycznych, które nie wskazują na ich pierwotne pochodzenie, a wiele jego twierdzeń przedostało się do wiedzy naukowej i potocznej, kształtując w istotny sposób opinię na temat okresu okołoporodowego.
The Impact of the COVID-19 Pandemic on Syphilis: A Retrospective Study among the Ege University HIV Cohort
Authors: Acet Oguzhan , Dirik Sukru , Pullukcu Husnu , Tasbakan Meltem , Gokengin Deniz 
Published: December 2024

Introduction/Objective:
The SARS-CoV-2 pandemic has led to significant changes in
the lives, habits, and frequency of hospital admissions of People Living with HIV (PLWH). However,
information is limited on the changes in the sexual behavior of these individuals and the resulting
Sexually Transmitted Infections (STIs). This study aimed to determine the trends in
syphilis among the Ege University HIV cohort before and during the pandemic.

Methods:
All PLWH who presented to the HIV outpatient clinic of Ege University Faculty of
Medicine, Department of Infectious Diseases and Clinical Microbiology, for HIV care for the first
time between January 1st, 2008 and October 1st, 2022, and whose laboratory results for syphilis
were available, were reviewed. Those presenting between January 1st, 2008, and March 11th, 2020,
were defined as the pre-pandemic (group A) cases, and those presenting between March 12th,
2020, and October 1st, 2022, were defined as the pandemic period (group B) cases. Clinical and
laboratory information about the cases was obtained retrospectively from medical records.

Results:
The number of PLWH who presented to the clinic for a first visit with a new HIV diagnosis
or follow-up between the specified dates was 1283 (956 group A, 327 group B). Overall, 155
(%12.1) PLWH were diagnosed with syphilis. A total of 204 syphilis episodes occurred during
6,173 Person-years of Follow-up (PYFU). Of these episodes, 86 (42.1%) were diagnosed in the
pre-pandemic period, and 118 (57.8%) during the pandemic. The number of episodes during the
pandemic was significantly higher in group A than in the pre-pandemic period (3.47 per 100 PYFU
and 2.57 per 100 PYFU, respectively; p=0.0434). When comparing the number of episodes
during the pandemic period, compared to group A, group B members had a significantly higher
number of syphilis episodes during the pandemic (3.47 and 7.81 per 100 PYFU, respectively;
p<.001).

Conclusion:
This study shows that syphilis rates remained high during the pandemic. Healthcare
providers are recommended to prepare PLWH for potential emergencies to be encountered in the
future and repeatedly remind them to use prevention in all high-risk circumstances.
The Role of Long Non-coding RNA ZFAS1 in Gliomagenesis: A Scoping Review
Authors: Amiruddin Engku Maryam Afifah Engku Omar , Rahman Amirah Abdul , Usoff Muhammad Fawwaz Mohd , Kadir Siti Hamimah Sheikh Abdul , Ibrahim Kamariah , Osman Nora Julianna 
Published: December 2024

Background:
Non-coding RNA species play important roles in biological mechanisms that
regulate glioma initiation and progression. Recently, evidence suggested that ZNFX1 antisense RNA
1 (ZFAS1) has the ability to act as an oncogene or tumour suppressor, and so plays critical regulatory
functions in the development and progression of many types of cancers such as lung, renal and hepatocarcinoma.
The roles of ZFAS1 in glioma cancer are still unclear, and there are numerous potential
pathways to explore.

Objective:
The aim of this scoping review is to provide an overview of the role of ZFAS1 in gliomagenesis,
outline existing research on its mechanisms in glioma, and identify any knowledge gaps.

Method:
A literature search was carried out using Scopus, PubMed, and Web of Science (WoS) using
a specified search string, and the data gathered was discussed and reported.

Results:
This scoping review comprised five original research papers that study ZFAS1 and its roles
in gliomagenesis. ZFAS1 was found to be highly upregulated in glioma. and overall survival was
revealed to be significantly associated with ZFAS1 status and regulated via several pathways and
interactions, such as miRNA signalling, Epithelial to Mesenchymal transition (EMT) and Notch
signalling pathway. Furthermore, ZFAS1 knockdown decreased cell proliferation, migration, and
invasion while promoting cell death, implying that ZFAS1 is involved in glioma cancer progression.

Conclusion:
The evaluation of their diagnostic importance and therapeutic potential may aid in the
development of novel therapies for glioma cancer.
Phenolic Compounds and Antioxidant Activity in Monovarietal Red Wines from Lazio Cultivars: A Chemometric Evaluation
Authors: Vinci Giuliana , Prencipe Sabrina Antonia , Renzo Matteo Di , Ruggeri Marco , Campana Paola , Tarola Anna Maria 
Published: December 2024

Background:
Antioxidant activity is currently one of the most significant characteristics
of red wines, mainly attributable to phenolic components, that enhance health-promoting
effects. To this purpose, it is necessary to implement simple, and reliable analytical methods
for evaluating such bioactive compounds in wines according to their background.

Objective:
This research aims to characterize the phenolic and antioxidant activity of 48 commercial
monovarietal red wines produced from eight native Lazio cultivars (“Cesanese del
Piglio”, “Cesanese di Olevano Romano”, “Cesanese da Castel Franco”, “Olivella del
Frusinate”, “Nostrano”, “Syrah”, “Merlot”, and “Nero Buono”), according to different winemaking
techniques and vintage.

Methods:
The characterization was carried out through the chromatographic determination of
anthocyanins (HPLC-PDA), spectrophotometric assays for total phenolic content (TPC), total
flavonoid content (TFC), total phenolic acid content (TPAC), and antioxidant activity (AA)
through ABTS, and DPPH assays, coupled with chemometric tools (Principal Component
Analysis and Cluster Analysis).

Results:
The quantitative determination of phenolic compounds showed significant (p > 0.05)
differences according to wine cultivars. Wine belonging to ‘Syrah’, ‘Nero Buono’, ‘Cesanese
del Piglio’ and ‘Cesanese di Olevano Romano’ cultivars showed the highest TPC (2.673 –
4.094; 1.963 – 3.859, 2.104 – 3.794, and 2.668 – 3.549 mg GAE/L, respectively), as well as the
highest TFC and TPAC.

Conclusion:
In addition, wines sharing cold maceration (i.e., COR and CP samples) resulted in
the highest total anthocyanidin content with a variable malvidin and cyanidin distribution percentage;
as well as younger wines (2019) showed the highest TPC and anthocyanidins content.
In these regards, the natural groupings among samples obtained by chemometrics reinforce the
influence of cultivar origin, the wine-making process, as well as wine aging on phenolic content
and compositions, thus acting as fingerprints for specific grape cultivars.
Perivascular Epithelial Cell Tumor of the Stomach Diagnosed Preoperatively by Endoscopic Ultrasound-Guided Fine-Needle Aspiration
Authors: Wang Limei , Zhang Jing 
Published: December 2024

Introduction:
Perivascular Epithelioid Cell tumor (PEComa) is a rare mesenchymal neoplasm characterized by the co-expression of melanocytic and myoid
markers. While PEComas can arise in diverse anatomical sites, gastric PEComas are exceedingly rare, with merely nine cases documented in the
extant literature.

Case Presentation:
Herein, we have presented a case of gastric PEComa in a 65-year-old male patient who exhibited a 3-year history of epigastric pain, with notable
exacerbation in the two months prior to diagnosis. For the initial evaluation of the patient's condition, Endoscopic Ultrasound-guided Fine Needle
Aspiration (EUS-FNA) and Computed Tomography (CT) were employed, which enabled a preoperative diagnosis. Radiological assessment
demonstrated a neoplasm exhibiting heterogeneous arterial enhancement, persistent delayed enhancement, and distinct margins. Subsequent to
diagnosis, the patient underwent surgical resection and has maintained a disease-free status for one year postoperatively. This case report highlights
the crucial role of EUS-FNA in facilitating preoperative histological diagnosis and optimizing surgical planning for gastric PEComa.

Conclusion:
This case constitutes the tenth documented instance of gastric PEComa in the global literature. In this case, EUS-FNA facilitated a preoperative
histopathological diagnosis, thereby enabling precise surgical planning. An accurate preoperative diagnosis is crucial for devising an optimal
treatment strategy.
A 17-Years Follow-up of Occupational Radiation Doses in an Interventional Cardiology Department
Authors: Kostova-Lefterova Desislava , Mateev Hristo , Aleksandrov Aleksandar , Ivanova Elena , Vladimirov Georgi , Bankova Aleksandra , Simeonov Filip , Stanev Stefan 
Published: December 2024

Introduction:
Various studies have demonstrated large variations in the annual occupational exposure of medical personnel working in interventional cardiology
departments, ranging from 0.1 mSv to exceeding the annual effective occupational dose limit of 20 mSv.

Purpose:
The purpose of this study was to investigate the 17-year dynamics in the personal dosimetry records of the medical staff in one interventional
cardiology department in Bulgaria.

Methods:
The study was performed between 2007 and 2023 and included 31 interventional cardiologists. For each of them, data from all individual
dosimetry control reports were analysed. The number and complexity of interventional procedures were analysed on an annual basis. A total
number of 39639 procedures performed over 17 consecutive years were classified and analysed.

Results:
The results have suggested that when a newly formed team gains clinical experience, the focus shifts towards optimizing radiation exposure to
patients, and it has been observed to change from 40 Gy.cm2 in 2009 to 14.8 Gy.cm2 in 2023 for diagnostic and from 146 Gy.cm2 in 2009 to 51.2
Gy.cm2 in 2023 for interventional procedures, and from 19.5 mSv/year under the lead apron in 2012 and 3.7 mSv/year in 2023 for one of the
interventional cardiologists among the medical staff. The optimization process in the department has been found to be slow but consistent, starting
with the routine application of basic methods to reduce the likelihood of skin injury. Any practical implementation of a methodology or process
requires periodic training to raise awareness of the topic and the use of different strategies to put it into practice. Most of the reported values from
individual dosimetry monitoring have been found to be in the range below 4 mSv/year, consistent with the summarised results from other studies.

Conclusion:
The radiation protection awareness program introduced in 2014 has been found to result in between a 2- and 6-fold reduction in individual
effective doses for some staff members and a 2-fold reduction in typical patient doses.
Luminescent and Scintillation Properties of LiLu(PO3)4:Pr3+Nanophosphor
Authors: Horchani-Naifer Karima 
Published: December 2024

Background:
Recent advancements in luminescent materials have drawn significant interest
due to their wide-ranging applications in radiation detection, lighting, and display technologies.
Praseodymium-doped phosphates, in particular, have shown promise because of their unique
luminescent and scintillation properties.

Objective:
This study aims to synthesize, characterize, and evaluate the luminescent and scintillation
properties of praseodymium-doped polyphosphate LiLu(PO3)4, focusing on the potential applications
of these materials.

Methods:
LiLu(PO3)4:Pr3+ microcrystals were synthesized using the flux method, while nanocrystals
were produced via the coprecipitation technique. The synthesized polyphosphates were characterized
using X-ray diffraction (XRD), scanning electron microscopy (SEM), and photoluminescence
(PL) spectroscopy.

Results:
LiLu(PO3)4:Pr3+ crystals were found to crystallize in the monoclinic C2/c space group
with specific lattice parameters. The structural analysis revealed that the basic units are helical ribbons
of (PO3)n formed by corner-sharing PO4 tetrahedra, with LuO8 dodecahedra and LiO4 tetrahedra
forming linear chains. The incorporation of praseodymium ions resulted in the observation of
both ultraviolet and visible luminescence under X-ray and laser excitations. UV emission, originating
from 4f-5d → 4f2 transitions, exhibited a very fast lifetime (τ4f-5d = 3 ns), while visible emission
from transitions within the Pr3+ 4f2 ground configuration showed a short decay time of approximately
100 ns.

Conclusion:
The scintillation properties of LiLu(PO3)4:Pr3+ demonstrated promising results, indicating
their potential for various high-performance applications, including solid-state lighting, bioimaging,
and radiation detection.
Effect of Azadirachta indica Leaf Extract on the Toxicity Induced by Ethyl Methanesulphonate (EMS) in the Third Instar Larvae of Transgenic Dro-sophila melanogaster (hsp70-lacZ) Bg9
Authors: Ansari Samra Zaki , Varshney Himanshi , Gaur Kajal , Subhan Iqra , Fatima Javeria , Ara Gulshan , Siddique Yasir Hasan 
Published: December 2024

Background:
Neem, known for its medicinal benefits, such as anti-inflammatory, antioxidant, and anti-cancer properties, can serve as a complementary or al-ternative treatment. Research has also indicated that neem extracts lessen the harmful ef-fects of the chemotherapy drug cisplatin on healthy cells while still preserving its ability to target cancer cells effectively. Different parts of the Neem tree, such as leaves, bark, fruit, flowers, oil, and gum, have been traditionally used in herbal medicine for treating various health conditions, including cancer, hypertension, heart disease, and diabetes.

Objective:
The effect of neem extract was studied on the Ethyl methanesulphonate (EMS) (an anti-cancerous drug)-induced toxicity in the third instar larvae of transgenic Drosophi-la melanogaster (hsp70-lacZ) Bg9.

Methods:
The third instar larvae were exposed to 25 μM of EMS alone and along with 4×10-3g/ml, 8×10-3g/ml, 12×10-3g/ml, and 16×10-3g/ml of neem extract (NE) mixed in diet for 24 hrs.

Results:
A significant increase in toxicity was observed in the larvae exposed to 25 μM of EMS. A dose-dependent significant decrease in the toxic effects was observed in the lar-vae exposed to various doses of neem extract. The GCMS analysis of the neem extract showed the presence of Phytol and α-tocopherol as major compounds.

Conclusion:
The reduction in the toxicity induced by EMS is mainly attributed to phytol and α-tocopherol.

conclusion:
The reduction in the toxicity induced by EMS is mainly attributed to phytol and α-tocopherol.