bluuebunny/crossref_metadata_2025_split huggingface dataset:
Determination of Phenolic Contents by HPLC, and Antioxidant, Antimicrobial, Antityrosinase, and Anticholinesterase Activities of Psephellus huber-morathii
Authors: Korkmaz Nuriye , Sener Sıla Ozlem , Balturk Nuray , Kanbolat Seyda , Badem Merve , Aliyazicioglu Rezzan , Ozgen Ufuk , Kandemir Ali , Karaoglu Sengul Alpay 
Published: March 2019

The goal of our study was to examine of antioxidant, antimicrobial, anticholinesterase activities, and phenolic composition of Psephellus huber-morathii. The antioxidant activities of extracts have been assessed by Ferric reducing antioxidant power (FRAP), cupric reducing antioxidant capacity (CUPRAC), and 2,2-diphenylpicrylhydrazyl (DPPH) radical scavenging. Phenolic constituents were measured using reverse phase-high performance liquid chromatography (RP-HPLC), and antimicrobial activity was investigated using the agar well diffusion method. Total phenolic content, FRAP, and CUPRAC results of aqueous extract have been better than methanolic extract, except for DPPH activity. Benzoic acid, and p-coumaric acid as major phenolic compounds were specified. Methanolic extract was especially effective against all microorganisms tested except for Yersinia pseudotuberculosis. The methanolic extract have been displayed inhibitory effect on tyrosinase. All extracts have been exhibited lower acetylcholinesterase, and butyrylcholinesterase inhibitory activities than galantamine. P. huber-morathii can be considered in the food, and drug industries due to antioxidant capacity and antimicrobial activities of the species. It can be potential source as anti-browning agents because of its average tyrosinase inhibitory activity.
Geographic Disparities in Gynecologic Oncology Clinical Trial Availability in the US
Authors: Boland Mary Regina , Tubridy Elizabeth , Solorzano Sebastian Spataro , Simpkins Fiona , Smith Anna Jo Bodurtha , Ko Emily M. 
Published: November 2024

ImportanceDisparities in minoritized racial and ethnic populations’ participation in gynecologic cancer clinical trials are well documented despite the high rates of endometrial cancer in these populations. Geographic proximity to trials is a critical component to ensure equitable trial access.ObjectiveTo characterize the geographic distribution of gynecological cancer trials across the US and identify disparities.Design, Setting, and ParticipantsThis study is a cross-sectional analysis of trials first posted on ClinicalTrials.gov from January 1, 2013, through January 10, 2024. This study involved a state-level analysis of clinical trials located in the US. Enrollment criteria of clinical trials for ovarian, uterine, cervical, endometrial, vaginal and/or vulvar, and other gynecological cancers were reviewed to exclude nongynecological cancers (1643 trials) or noninvasive gynecological conditions (224 trials).ExposureThe number of gynecological trials per 100 000 persons in each state.Main Outcomes and MeasuresA state-level analysis was performed to determine whether gynecologic cancer clinical trial availability in the US is associated with other state-level characteristics to identify areas of increased need. Census data, state-level total population size, percentage of non-Hispanic White persons, and the Federal Emergency Management Agency expected annual loss per state as a measure of social vulnerability were aggregated. The association between these variables and the number of gynecological trials per 100 000 persons was measured using Spearman rank correlation.ResultsOf the 1561 invasive gynecological cancer trials that met the inclusion criteria, most cancer trials were ovarian (911 trials [58.4%]), followed by cervical (438 trials [28.1%]), and endometrial (385 trials [24.7%]). Predominantly minoritized population–serving states (ie, those with &amp;lt;50% non-Hispanic White persons) had fewer than 4 trials per 100 000 persons, but this was not significant nationally (ρ = 0.20; 95% CI, −0.08 to 0.45; P = .16). States with higher Federal Emergency Management Agency expected annual loss had lower numbers of gynecological trials per 100 000 persons, which was significant nationally (ρ = −0.53; 95% CI, −0.70 to −0.29; P &amp;lt; .001).Conclusions and RelevanceIn this cross-sectional study of female gynecological cancer trials by state, states with particularly high economic vulnerability and minoritized populations had low clinical trial availability. Further efforts are needed to address disparities identified in this study to ensure equitable trial access.
Electrically Generated Exciton Polaritons with Spin On‐Demand
Authors: Wang Yutao , Adamo Giorgio , Ha Son Tung , Tian Jingyi , Soci Cesare 
Published: November 2024

AbstractGeneration and manipulation of exciton polaritons with controllable spin could deeply impact spintronic applications, quantum simulations, and quantum information processing, but is inherently challenging due to the charge neutrality of the polariton and the device complexity it requires. Here, electrical generation of spin‐polarized exciton polaritons in a monolithic dielectric perovskite metasurface embedded in a light‐emitting transistor is demonstrated. A finely tailored interplay of in‐ and out‐of‐plane symmetry breaking of the metasurface allows to lift the spin degeneracy through the polaritonic Rashba effect, yielding high spin purity with normalized Stokes parameter of S3 ≈ 0.8. Leveraging on spin‐momentum locking, the unique metatransistor device architecture enables electrical control of spin and directionality of the polaritonic emission. Here, the development of compact and tunable spintronic devices is advanced and an important step toward the realization of electrically pumped inversionless spin‐lasers is represented.
Deciphering the Causes of the Rapid Electroluminescence Loss in Blue Quantum Dot Light‐Emitting Devices
Authors: Azadinia Mohsen , Aziz Hany 
Published: November 2024

AbstractElectroluminescence (EL) loss mechanisms in quantum dot light‐emitting devices (QLEDs), especially blue (B) emitting ones, remain unclear. Here, it is identified that – aside from some partially reversible deterioration in the photoluminescence quantum yield (PLQY) of the quantum dots‐emissive layer (QDs‐EML) – the rapid EL loss in B‐QLEDs is caused mainly by an increase in electron leakage‐across the hole transport layer (HTL) and a subsequent damage to the hole injection layer (HIL), resulting in a deterioration in hole supply to the QDs EML. EL and PL measurements on devices with marking layers (MLs) placed in different locations uncover that electron supply to the QDs‐EML is easier than hole supply in B‐QLEDs in general, causing the electron (e)/hole (h) to be >1 and significant electron leakage to the HIL, even in fresh devices. Under electrical stress, this electron leakage increases further, causing the charge imbalance in the QDs‐EML to deteriorate further and more electrons to reach the HIL. The selective peel‐off‐and‐rebuilt experiment verifies the HIL changes and the role of electrons in inducing them. Modified devices with reduced electron supply show 30X longer EL lifetime, proving the role of excess electrons in the rapid EL loss in B‐QLEDs.
Self‐Healing COCu‐Tac Hydrogel Enhances iNSCs Transplantation for Spinal Cord Injury by Promoting Mitophagy via the FKBP52/AKT Pathway
Authors: Tian Zhenming , Hu Han‐Jian , Chan Chun Cheung , Hu Tian , Cai Chaoyang , Li Hong , Rong Limin , Jiang Gang‐Biao , Liu Bin 
Published: November 2024

AbstractIn the realm of neural regeneration post‐spinal cord injury, hydrogel scaffolds carrying induced neural stem cells (iNSCs) have demonstrated significant potential. However, challenges such as graft rejection and dysfunction caused by mitochondrial damage persist after transplantation, presenting formidable barriers. Tacrolimus, known for its dual role as an immunosuppressant and promoter of neural regeneration, holds the potential for enhancing iNSC transplantation. However, systemic administration of tacrolimus often comes with severe side effects. This study pioneers the development of a self‐healing hydrogel with sustained‐release tacrolimus (COCu‐Tac), tailored specifically for iNSC transplantation after spinal cord injury. This research reveals that the sustained release of tacrolimus enhances axonal growth and improves mitochondrial quality control in iNSCs and neurons. Further analysis shows that tacrolimus targets FKBP52 rather than FKBP51, enhancing mitophagy via the FKBP52/AKT pathway. This advanced system demonstrates significant efficacy in promoting neural regeneration and restoring motor function following spinal cord injury.
ZFP36 Regulates Vascular Smooth Muscle Contraction and Maintains Blood Pressure
Authors: Cui Xiuru , Wang Yawei , Lu Hanlin , Wang Lei , Xie Xianwei , Zhang Shenghao , Kovarik Pavel , Li Shuijie , Liu Shanshan , Zhang Qunye , Yang Jianmin , Zhang Cheng , Tian Jinwei , Liu Yan , Zhang Wencheng 
Published: November 2024

AbstractHypertension remains a major risk factor for cardiovascular diseases, but the underlying mechanisms are not well understood. Zinc finger protein 36 (ZFP36) is an RNA‐binding protein that regulates mRNA stability by binding to adenylate‐uridylate‐rich elements in the mRNA 3′‐untranslated region. This study reveals that ZFP36 expression is highly elevated in the arteries of hypertensive patients and rodents. In cultured vascular smooth muscle cell (VSMC), angiotensin II (AngII) activates poly (ADP‐ribose) polymerases1 (PARP1) to stimulate Zfp36 expression at the transcriptional level. VSMC‐specific ZFP36 deletion reduces vessel contractility and blood pressure levels in mice. Mechanistically, ZFP36 regulates G protein‐coupled receptors (GPCRs)‐mediated increases in intracellular calcium levels through impairing the mRNA stability of regulator of G protein signaling 2 (RGS2). Moreover, the VSMC‐specific ZFP36 deficiency attenuates AngII‐induced hypertension and vascular remodeling in mice. AAV‐mediated ZFP36 knockdown ameliorates spontaneous hypertension in rats. These findings elucidate that ZFP36 plays an important role in the regulation of smooth muscle contraction and blood pressure through modulating RGS2 expression. ZFP36 inhibition may represent a new therapeutic strategy for the treatment of hypertension.
Tubular MYDGF Slows Progression of Chronic Kidney Disease by Maintaining Mitochondrial Homeostasis
Authors: Liu Xiaohan , Zhang Yang , Wang Youzhao , Yang Yujie , Qiao Zhe , Zhan Ping , Jin Huiying , Xu Qianqian , Tang Wei , Sun Yu , Zhang Yan , Yi Fan , Liu Min 
Published: November 2024

AbstractMitochondrial dysfunction is a key event driving the maladaptive repair of tubular epithelial cells during the transition from acute kidney injury to chronic kidney disease (CKD). Therefore, identifying potential targets involved in mitochondrial dysfunction in tubular epithelial cells is clinically important. Myeloid‐derived growth factor (MYDGF), a novel secreted protein, plays important roles in multiple cardiovascular diseases, but the function of MYDGF in tubular epithelial cells remains unknown. In the present study, it is found that MYDGF expression is significantly reduced in the cortex of the kidney, especially in the proximal tubules, from mice with CKD. Notably, lower expression of MYDGF is observed in tubules from patients with CKD and the level of MYDGF correlated with key factors related to kidney fibrosis and estimated glomerular filtration rate (eGFR) in patients with CKD. Tubule‐specific deletion of Mydgf exacerbates kidney injury in mice with CKD; however, Mydgf overexpression attenuates kidney fibrosis by remodeling mitochondrial homeostasis in tubular epithelial cells. Mechanistically, renal tubular MYDGF positively regulates the expression of isocitrate dehydrogenase 2 (IDH2), restores mitochondrial homeostasis, and slows CKD progression. Thus, this study indicates that MYDGF derived from tubules may be an effective therapeutic strategy for patients with CKD.
Engineering Magnetic Heterostructures with Synergistic Regulation of Charge‐Transfer and Spin‐Ordering for Enhanced Water Oxidation
Authors: Hao Chongyan , Wu Yang , Zheng Xiaobo , Du Yumeng , Fan Yameng , Pang Weikong , Tadich Anton , Zhang Shujun , Frauenheim Thomas , Ma Tianyi , Li Xiaoning , Cheng Zhenxiang 
Published: November 2024

AbstractThe design of heterojunctions offers a crucial solution for energy conversion and storage challenges, but current research predominantly focuses on charge transfer benefits, often neglecting spin attribute regulation despite the increasing recognition of spin‐sensitivity in many chemical reactions. In this study, a novel magnetic heterostructure, CoFe2O4@CoFeMo3O8, is designed to simultaneously modulate charge and spin characteristics, and systematically elucidated their synergistic impact on the oxygen evolution reaction (OER). Experimental results and density functional theory calculations confirmed that the magnetic heterostructure exhibits both charge transfer and spin polarization. It is found that the charge‐transfer behavior enhances conductivity and adsorption ability through band structure regulation. Meanwhile, magnetically polarized electrons promote triplet O2 generation and accelerate electron transport via spin‐selective pathways. Moreover, the heterostructure's effective response to external alternating magnetic fields further amplifies the spin‐dependent effect and introduces a magnetothermal effect, locally heating the active sites through spin flip, thereby boosting catalytic activity. Consequently, the OER activity of the magnetic heterostructure is improved by 83.8 times at 1.5 V compared to its individual components. This magnetic heterojunction strategy presents a promising avenue for advanced catalysis through synergistic regulating of charge‐transfer and spin‐ordering.
Incorporation of Lewis basic sites into Zn‐pyrazolate frameworks for efficient methane/nitrogen separation
Authors: Liu Jiaqi , Miao Jiafeng , Ma Lulu , Li Jinping , Li Jing , Wang Hao 
Published: November 2024

AbstractThe separation of methane (CH4) and nitrogen (N2) in coalbed methane (CBM) is a crucial process to produce methane as a clean energy source. Given the similar physicochemical properties of the two gases, efficient adsorptive separation of CH4 and N2 has stringent requirements on the pore chemistry and geometry of the adsorbents. In this study, we report two Zn‐pyrazolates frameworks, HIAM‐213 and HIAM‐214, which possess Lewis basic sites that exhibit precise recognition of CH4 over N2. The capability of these compounds in extracting CH4 from binary CH4/N2 mixtures has been confirmed through column breakthrough measurements, demonstrating a high recovery rate under mild regeneration conditions. Grand canonical Monte Carlo simulations and in situ Fourier transform infrared spectroscopy experiments provide insights into the selective adsorption mechanism by revealing stronger interactions between CH4 and Lewis acid sites.
Elucidating Confinement and Microenvironment of Ru Clusters Stably Confined in MFI Zeolite for Efficient Propane Oxidation
Authors: Wang Jingjing , Jiang Zeyu , Xu Hengyue , Li Xinzhe , Jian Yanfei , Xia Lianghui , Su Pei , Liu Qiyuan , Chai Shouning , Ma Mudi , Amedlous Abdallah , Barreau Mathias , Hao Zhengping , Yu Jiaguo , He Chi 
Published: November 2024

AbstractAchieving active and stable heterogeneous catalysts by encapsulating noble metal species within zeolites is highly promising for high utilization and cost efficiency in thermal and environmental catalytic reactions. Ru, considered an economical noble metal alternative with comparable performance, faces great challenges within MFI‐type microporous zeolites due to its high cohesive energy and mobility. Herein, an innovative strategy was explored that couples hydrothermal in situ ligand protection with stepwise calcination in a flowing atmosphere to embed ultrasmall Ru clusters anchored at K+‐healed silanol sites (≡Si−Ruδ+−O−K complexes) within 10‐membered ring sinusoidal channels of MFI. Comprehensive experiments and theoretical calculations unveiled that the interplay between confined Ru clusters and MFI induces local strain in MFI, creating a unique catalytic microenvironment around the Ru clusters. This synergy interaction enhances alkane deep oxidation as the confined Ru clusters and the MFI microenvironment collectively pre‐activate C3H8 and O2, facilitate the cleavage of C−H and C−C bonds at low temperatures. Notably, the stable geometric and electronic properties of the confined Ru show exceptional thermal stability up to 1000 °C, rivaling fresh catalysts. These findings shed vital methodological and mechanistic insights for developing efficacious heterogeneous catalysts for thermal catalysis.
Ethane Triggered Gate‐Opening in a Flexible‐Robust Metal‐Organic Framework for Ultra‐High Purity Ethylene Purification
Authors: Zhang Lu , Yu Bin , Wang Meng , Chen Yang , Wang Yong , Sun Lin‐Bing , Zhang Yue‐Biao , Zhang Zhenjie , Li Jinping , Li Libo 
Published: November 2024

AbstractPriority recognition separation of inert and larger ethane molecules from high‐concentration ethylene mixtures instead of the traditional thermodynamic or size sieving strategy is a fundamental challenge. Herein, we report ethane triggered gate‐opening in the flexible‐robust metal‐organic framework Zn(ad)(min), the 3‐methylisonicotinic acid ligand can spin as a flexible gate when adsorbing the cross‐section well‐matched ethane molecule, achieving an unprecedented ethane adsorption capacity (62.6 cm3 g−1) and ethane/ethylene uptake ratio (3.34) under low‐pressure region (0.1 bar and 298 K). The ethane‐induced structural transition behavior has been uncovered by a collaboration of single‐crystal X‐ray diffraction, in situ variable pressure X‐ray diffraction and theoretical calculations, elucidating the synergetic mechanism of cross‐section matching and multiple supramolecular interactions within the tailor‐made pore channels. Dynamic breakthrough experiments have revealed the outstanding separation performance of Zn(ad)(min) during the production of ultra‐high purity ethylene (>99.995 %) with a productivity of up to 39.2 L/kg under ambient conditions.
H Induced Metal‐Insulation Transition Boosts the Stability of High Temperature Polymer Electrolyte Membrane Fuel Cells
Authors: Lin Liguang , Cai Zhiwei , Niu Yuanfei , Wu Yujie , Wang Jingjing , Li Miaoyu , Li Dong , Wang Tehua , Wang Zhengbang , Tao Li , Wang Shuangyin 
Published: November 2024

AbstractHigh temperature polymer electrolyte membrane fuel cells (HT‐PEMFCs) have garnered significant attention due to their expanded range of hydrogen sources and simplified management systems. However, the frequent start‐up and shut‐down (SU/SD) caused fuel starvation operation condition seriously deteriorates the performance and lifetime of the fuel cell. In this manuscript, VO2 was incorporated in the anode to restrain fuel starvation of the electrode. Under the operation condition, the insulative VO2 would reversibly transform into metallic HxVO2 by intercalating hydrogen, and HxVO2 can automatically release hydrogen, which could act as the hydrogen buffer and suppress reverse‐current degradation. After the hydrogen release, the generated insulating VO2 would prevent the side reactions during fuel starvation. Compared to the traditional Pt anode, the electrode with VO2 showed much higher output power and greatly improved durability after fuel starvation. This work demonstrates the in situ reversible hydrogen storage/release‐controlled metal‐insulator phase transition strategy to enhance the durability of fuel cells.
Skeletal Nitrogen Functionalization of Isostructural 2D Conjugated MOFs for Enhancement of the Dual‐Ion Storage Capacity
Authors: Sporrer Lukas , Guo Quanquan , Li Xiaodong , Wrzesinska‐Lashkova Angelika , Reichmayr Fanny , Fu Shuai , Wang Hai I. , Bonn Mischa , Li Xiangyu , Laval‐Schmidt Paul‐Alexander , Wang Mingchao , Lu Yang , Vaynzof Yana , Yu Minghao , Feng Xinliang , Dong Renhao 
Published: November 2024

AbstractTwo‐dimensional conjugated metal–organic frameworks (2D c‐MOFs) are emerging as promising electrode materials for electrochemical energy storage devices. However, a viable path to realize superior dual‐ion storage in 2D c‐MOFs has remained elusive. Here, we report the synthesis of Cu2(Nx−OHPTP) 2D c‐MOFs (x=0,1,2; OHPTP=octahydroxyphenanthrotriphenylene) with precise aromatic carbon‐nitrogen arrangements, based on the π‐conjugated OHPTP ligand incorporated with one or two nitrogen atoms. The skeletal nitrogen modification in Cu2(Nx−OHPTP) allows the synergistic introduction of additional redox sites, and thus substantially favors the unique dual‐ion adsorption capacity. Consequently, the Cu2(N2−OHPTP) cathode exhibits a largely enhanced electrochemical performance for dual‐ion storage (i.e., Li+ and Cl‐) with a high specific capacity of 53.8 mAh g−1, which is twice that of Cu2(N0−OHPTP) and 1.3 times that of Cu2(N1−OHPTP). Furthermore, the Cu2(N2−OHPTP) electrode displays a favorable rate performance of 52 % and good cycling stability of 96 % after 1000 cycles. We identify N‐centered redox sites as additional Li+ adsorption sites by combining ex situ and in situ spectroscopy measurements and theoretical calculations. In addition, calculations underline the synergistic enhancement of the Cl− adsorption energy by about 1.0 eV at the more electron‐poor CuO4 linkages after N‐incorporation. This work paves the way for the precise design of 2D c‐MOFs with superior electrochemical properties, advancing their application in dual‐ion storage applications.
Transmembrane Delivery of an Aryl Azopyrazole Photo‐switchable Ion Transporter Relay
Authors: Grählert Elin , Langton Matthew J. 
Published: November 2024

AbstractStimuli‐responsive synthetic ionophores allow for spatial and temporal control over ion transport, with promise for applications in targeted therapy. Relay transporters have emerged as a new class of ion transporters ‐ these are anchored carriers that sit in both leaflets of the bilayer and mediate transport across the membrane by passing ions between them. The relays are themselves membrane impermeable, and so must be incorporated into the membrane during vesicle preparation. Here we show that relay transporters can be delivered to both sides of the membrane of vesicles using a synthetic flippase. By incorporating an aryl azopyrazole photo‐switch into the movable arm of the relay transporters the ion transport activity can be very efficiently and reversibly switched between off and on states. This control is achieved by extension and contraction of their movable arms via photo‐isomerization of the central aryl azopyrazole moiety, hence modulating the ability of the relays to pass ions across the membrane.