bluuebunny/crossref_metadata_2025_split huggingface dataset:
Adjuvant Trastuzumab Therapy: Can We Balance Efficacy and Safety?
Authors: Barron Carly C. , Tyagi Nidhi Kumar , Alhussein Muhammad Mustafa , Mukherjee Som D. , Ellis Peter M. , Dhesy-Thind Sukhbinder , Leong Darryl P. 
Published: July 2019

Abstract
Trastuzumab is an effective treatment for HER2-positive breast cancer. Current guidelines recommend withholding trastuzumab in patients experiencing a significant asymptomatic decline in left ventricular function. In this commentary, we discuss the survival benefits afforded by trastuzumab juxtaposed against the risk of trastuzumab-mediated cardiotoxicity. It is not known whether the net benefit of continuing trastuzumab in the setting of mild cardiotoxicity outweighs the associated risks. We describe a potential approach undertaken by our group, and others, and call for a randomized trial.
Women Watering Basil Plants: New Insights into a Spanish Moroccan Folktale
Authors: Duque Adriano 
Published: July 2019

This paper examines the Spanish song «Princesita que riega la albahaca» and compares it with other Moroccan versions of the folk tale. Although loosely based on the encounter between King Solomon and Queen Sheba, the story incorporates a series of elements from different folk traditions, while insisting on the motif of the husband-seeking maiden. Drawing on the motifs of the garden or the mother, the essay examines how the protagonist of the story uses the metaphor of the Basil plant to articulate relations of exogamy and to question social assumptions regarding the role of women and their social constraints.

El presente artículo examina la canción en español "Princesita que riega la albahaca" y la contrasta con otras versiones marroquíes del cuento. Aun basándose relativamente en el encuentro entre el rey Salomón y la reina de Saba, la historia incorpora una serie de elementos de diferentes tradiciones populares al tiempo que insiste en el motivo de la doncella que busca marido.A partir de los motivos del jardín o de la madre, el ensayo examina cómo el protagonista de la historia utiliza la metáfora de la planta de albahaca para articular relaciones de exogamia y para cuestionar los presupuestos sobre el papel de las mujeres y sus limitaciones en sociedad.
Preliminary characterization of the dominant baroclinic modes of a tropical Andean reservoir during a dry period
Authors: Posada-Bedoya Andrés , Gómez-Giraldo Andrés , Román Botero Ricardo 
Published: July 2019

A partir de datos de campo y un modelo numérico simple, se investigaron las ondas internas escala de cuenco en un embalse tropical andino durante un período seco. La estructura y el período de las oscilaciones baroclínicas observadas, se infirieron a partir del análisis espectral de las series de temperatura medidas y de los desplazamientos verticales de las isotermas asociadas. El modo de oscilación dominante identificado a partir de los datos de campo constaba de dos capas que oscilaban con velocidades verticales y fases contrarias (modo V2), y con un período de 24 h. Los modos baroclínicos verticales teóricos del embalse se estimaron a partir de un eigenmodelo simple, el cual predijo el período y la estructura vertical del modo dominante identificado a partir de las observaciones, indicando también que las oscilaciones de la velocidad horizontal en cada capa estaban en fase (modo V2H1) y con un período natural cercano a 24 h. El forzamiento del viento mostró una variabilidad periódica con un período dominante cercano a las 24 h, por lo que concluimos que el modo V2H1 fue el dominante durante el período analizado y sometido a excitación por resonancia con el forzamiento diurno del viento. Se modeló el embalse como un sistema lineal masa-resorte, amortiguado y forzado, con el fin de estimar la relación de amortiguamiento de las oscilaciones baroclínicas, y se obtuvieron oscilaciones subamortiguadas con una tasa de amortiguamiento similar a la reportada en otros lagos alrededor del mundo. También se investigó el potencial del modo V2H1 en la generación vertical de turbulencia debido a inestabilidades cortantes usando el número de Richardson del gradiente, y encontramos que la producción de turbulencia era baja. Por último, se discuten aquí la estructura vertical de la fase en las oscilaciones de las ondas internas y las potenciales implicaciones del campo de ondas internas en la ecología del embalse. © 2019. Acad. Colomb. Cienc. Ex. Fis. Nat.
Dickkopf-1 and Amphiregulin as Novel Biomarkers and Potential Therapeutic Targets in Hepatocellular Carcinoma
Authors: Awad Abeer E. , Ebrahim Mohamed A. , Eissa Laila A. , El-Shishtawy Mamdouh M. 
Published: July 2019

Background: Hepatocellular carcinoma (HCC) is a highly fatal tumor which represents a major health problem worldwide. Due to asymptomatic nature of HCC, most patients present with the progressive stage of disease, so, unfortunately, there are no effective therapies. Existing techniques for HCC surveillance and diagnosis lack the required accuracy. Therefore, searching for new diagnostic and/or therapeutic tools could improve patient survival. This study aimed to estimate the diagnostic role of Dickkopf-1 (DKK1) and amphiregulin (AREG) and to find out their correlation with different clinicopathological parameters in HCC patients.
Materials and Methods: Serum levels of DKK1 and AREG in 55 HCC patients, 20 cirrhotic patients, and 15 healthy subjects as control group were measured using the ELISA technique.
Results: Both of DKK1 and AREG showed a significant increase in the HCC group compared to cirrhotic and healthy groups. DKK1 at a cutoff point of 8.92 ng/ml showed that the area under the curve (AUC) was 0.826 with 87.3% sensitivity and 82.9% specificity. DKK1 showed a significant correlation with tumor size, liver dysfunction, and poor performance status in HCC patients. AREG at a cutoff point of 8.74 pg/ml showed a sensitivity of 74.5% but low specificity (47.1%). AREG showed a significant correlation with portal vein thrombosis and tumor metastasis in HCC patients.
Conclusion: Serum DKK1 could be a diagnostic biomarker for HCC. Both of DKK1 and AREG may play significant roles in tumor progression and may offer promising therapeutic targets in HCC patients.
SUPPORTING LOCATION FACTORS TOWARDS SALAK AGROINDUSTRIAL DEVELOPMENT IN SLEMAN AGROPOLITAN DISTRICT
Authors: Azhari Abimanyu Putra , Kusumastuti Kusumastuti , Andini Isti 
Published: July 2019

<p><em>Agropolitanconsept is developed as critics of industrial development failure in several Asian development countries which caused by high urbanization, unequal incomeand depletion of resources (Friedmann and Douglass, 1975). This consept also emphasize in agroindustrial development as part of successful agropolitan. Slemanagropolitan district has developed competitive commodites such as salak which can be process to high value products. AfterSlemanAgropolitan District established, the agroindustrial development still has not give the contribution for it. Many industries have limited quantity and there is no connection among other industries, so the industries just walked by itself. Many of them do not observe the important thing on their development, like location. Location has an important role for sustaining agroindustrial development. </em></p><p><em>Based on this issues, the research goal is the achievement value of supporting location factors to salakagroindustrial development in SlemanAgropolitan District. The method is scoring analysis in every location factors variable in agroindustrial development to find the value achivement of supporting location factors.</em></p><p><em>The result of this research, location factors have strongly support for salakagroindustrial development in SlemanAgropolitan District. Raw identified through origin, distance and how to gather the raw has value 96,4% which means strongly support. Labour identified through quantity, origin and distance has value 66,9% which means support. Market identified through origin, distance and how to distribute has value 90,6% which means strongly support. Transportation/accesibility identified through road, transportation cost and time has value 84,2% which means strongly support. Land identified through topography and disasten vulnerability has value 97,5% which means strongly support for agroindustrial development.</em></p><p><em> </em></p><p><strong><em>Keywords:</em></strong><em>agropolitan, agroindustrial development, location factor</em><em></em></p>
THE CORRELATION BETWEEN LANDUSE CHANGES WITH ROAD DENSITY IN URBAN FRINGE SOUTH SURAKARTA
Authors: Putri Dewangga Megaloka , Nurhadi Kuswanto , Rini Erma Fitria 
Published: July 2019

<em>From time to time the poplulation growth effect on the needs-of-lands. The growth of the city affect the changes of the sub-urban in a phisycal and activities. It arises as a result from the need-for-land that already not able to be fullfiled by the city Itself. Eventually, lands in the sub-urban transformed which previously dominated by non-built-up land turn into built-up land. The movements from sub-urban to city also increased. The feeder roads between sub-urban and the city gets more dense. The study aims to review developments on the land use and density of roads in the period of time between 2010 Until 2016 and the correlation between land use development and density of roads. This research is using deductive method and ordinal regression analysis techniques. The datas that be used are primary data obtained through field observation and secondary data through study documents. The result shows the correlation between the land use development and density urban roads in the South urban fringe in the Surakarta city</em>
La precipitación geomorfológica como elemento clave en el modelado del paisaje mediterráneo
Authors: Sillero Medina Jose Antonio , Hueso Gonzalez Paloma , Ruiz Sinoga José Damián 
Published: July 2019

El incremento de la frecuencia de la torrencialidad en ámbitos mediterráneos es una cuestión preocupante y no solo desde el punto de vista hidrogeomorfológico, sino también desde el humano, socioeconómico e infraestructural. La definición del umbral de torrencialidad es clave para determinar la peligrosidad de un territorio determinado. En este estudio ajustamos diferentes clasificaciones de torrencialidad con los problemas e impactos identificados en dos áreas mediterráneas contrastadas de la provincia de Málaga, una de ellas caracterizada por un clima mediterráneo subhúmedo (Guadalhorce), y otra por un clima mediterráneo seco-semiárido (Axarquía). A partir del análisis de los datos pluviométricos de 18 observatorios (Red SAIH), los resultados determinan una escasa recurrencia de los eventos torrenciales predefinidos (>100 mm 24 h-1; >60 mm h-1), razón por la que proponemos el uso de un nuevo umbral de torrencialidad de menor duración, pero mucha más elevada intensidad (>10 mm 10 min-1), debido a que son muchos los episodios producidos por debajo de los umbrales anteriores, pero con consecuencias territoriales, como hemos constatado en el análisis mediático. La precipitación que se ajusta a este criterio ha sido definida como “precipitación geomorfológica” por su elevada capacidad de generar alteraciones en los componentes superficiales del territorio. Este tipo de precipitación presenta en ambos ambientes una alta recurrencia, un periodo de retorno prácticamente anual y una elevada erosividad.
Effect of caudal ketamine on minimum local anesthetic concentration of ropivacaine in children: A prospective randomized trial
Authors: Wang Huai-Zhen , Wang Ling-Yu , Liang Hui-Hong , Fan Yan-Ting , Song Xing-Rong , She Ying-Jun 
Published: July 2019

Abstract
Background

Caudal ketamine has been shown to provide an effective and prolonged post-operative analgesia with few adverse effects. However, the effect of caudal ketamine on the efficacy of ropivacaine for intra-operative analgesia is unclear.

Methods

One hundred and sixty-nine children were randomized to five groups: Group C (caudal ropivacaine only), Group K0.25 (caudal ropivacaine plus 0.25 mg/kg ketamine), Group K0.5 (caudal ropivacaine plus 0.5 mg/kg ketamine), Group K0.75 (caudal ropivacaine plus 0.75 mg/kg ketamine), and Group K1.0 (caudal ropivacaine plus 1.0 mg/kg ketamine). The primary outcome was the minimum local anesthetic concentration (MLAC) of ropivacaine with/without ketamine for caudal block.

Results

The MLAC values of ropivacaine were 0.128% (0.028%) in the control group, 0.112% (0.021%) in Group K0.25, 0.112% (0.018%) in Group K0.5, 0.110% (0.019%) in Group K0.75, and 0.110% (0.020%) in Group K1.0. There were no significant differences among the five groups for the MLAC values (p=0.11). During the post-operative period the mean durations of analgesia were 270, 381, 430, 494, and 591 min in the control, K0.25, K0. 5, K0.75, and K1.0 groups respectively, which shown significant differences among the five groups (p<0.05).

Conclusions

Adding caudal ketamine to ropivacaine prolong the duration of post-operative analgesia; however, it does not decrease the MLAC of caudal ropivacaine for intra-operative analgesia in children.
Indications for adjuvant chemotherapy in patients with AJCC (7th ed.) stage IIa T3N0M0 and T1N2M0 gastric cancer – an east and west, multicenter study
Authors: Huang Ze-Ning , Desiderio Jacopo , Chen Qi-Yue , Zheng Chao-Hui , Li Ping , Xie Jian-Wei , Wang Jia-Bin , Lin Jian-Xian , Lu Jun , Cao Long-Long , Lin Mi , Tu Ru-Hong , Lin Ju-Li , Zheng Hua-Long , Huang Chang-Ming 
Published: July 2019

Abstract
Purpose

To determine the ideal indications of adjuvant chemotherapy(AC) in patients with stage IIa gastric cancer (T3N0M0 and T1N2M0) according to the 7th American Joint Committee on Cancer (AJCC) .

Method

1593 gastric cancer patients with T3N0M0 or T1N2M0 stage were identified from Surveillance, Epidemiology,and End Results(SEER) database in 1988.1-2012.12. Cox multiple regression, nomogram and decision curve was used.External validation was performed using database from Fujian Medical University Union Hospital(FJUUH)(n = 241) and Italy IMIGASTRIC center(n = 45).

Results

Cox multiple regression analysis showed that the risk factors that affected OS in Patients with AC were age > 65 years old, T1N2M0, LN dissection number ≤ 15, tumor size > 20 mm, and non-adenocarcinoma. Then a nomogram was constructed to predict 5-year OS and divided patients into a high-benefit from AC (points ≤ 188) or a low-benefit (points > 188) according to a recursive partitioning analysis.OS was significantly higher for the high-benefit patients in the SEER database and the FJUUH dataset than in the non-AC patients (Log-rank < 0.05), and there was no significant difference in OS between low-benefit patients and non-AC patients among the three centers (Log-rank = 0.154, 0.470, and 0.434, respectively). The decision curve indicated that the best clinical effect can be obtained when the threshold probability is 0-92%.

Conclusion

Regarding the controversy over whether T3N0M0 and T1N2M0 gastric cancer patients should be treated with AC, this study presents a predictive model that provides concise and accurate indications. These data show that high-benefit patients should receive AC.
Patients’ Perspectives of the Health Worker-patient Relationship in Cape Coast Metropolis, Ghana
Authors: Asamoah Kofi Tekyi , Appiah-Brempong Emmanuel , VAMPERE HASEHNI 
Published: July 2019

Abstract
Objective:
The importance of good interactions between health workers and patients cannot be over-emphasised. It calms troubled patients and allows them access to all pertinent information to ensure good health. However, some patients are harshly treated, compelling them to withhold sensitive and relevant information whiles others are given very little education on preventive health practices, hampering their preventive health practice. This study aimed to assess the health worker-patient relationship from the patients’ perspective and its effect on preventive health practices in the Cape Coast Metropolis, Ghana.
Results:
About 70% of patients were satisfied with how they are related to in hospital as 93.8% were allowed to express themselves freely without interruption by the doctor, though 22.7% believed they were not examined by the doctor. 53.1% of the participants were given explanations of their ailments, with 64.4% receiving information on how to prevent complications and recurrences. 70.7% left the consultation with a sense of control over personal health events. Below 50% were educated on intervention procedures, treatment regimens and side effects of their drugs. Generally, patients showed satisfaction with their interactions with health workers.
Evaluating occurrence of contaminants of emerging concerns in MF/RO treatment of primary effluent for water reuse – Pilot study
Authors: Farrokh Shad Mojtaba , Juby Graham J. G. , Delagah Saied , Sharbatmaleki Mohamadali 
Published: July 2019

Abstract
This study experimented with the novel approach of using a microfiltration (MF) and reverse osmosis (RO) treatment train to treat the effluent of a primary settling tank at the Inland Empire Utility Agency in Chino, CA. The pilot used polyvinylidene fluoride hollow-fiber MF modules as pretreatment for an RO skid, which used Hydranautics ESPA2 membranes in a two-stage configuration with a feed capacity of 6 gallon per minute (gpm). In this pilot configuration, researchers monitored the removal of 38 most prevalent contaminants of emerging concerns (CECs) through the MF/RO process. To investigate how operating the RO process at two fixed recovery rates of 55% and 80% would affect the performance of the MF/RO membranes, researchers applied different fluxes (8, 10, 12 and 14 gal/d/ft2 (gfd)) and evaluated the removal of CECs in 1-stage and 2-stage RO configurations. The occurrence of CECs in the MF influent, MF effluent, RO permeate, and RO concentrate were analyzed and studied. In the first phase (1-stage the RO process), flux of 14 gfd showed a better rejection value of inorganics (95.2%) when compared with those of other fluxes. Meanwhile, in the second phase (2-stage RO process), flux of 12 gfd showed a better rejection of inorganics (93.7%) when compared with those of other fluxes. Although concentrations of CECs slightly decreased in the RO permeate as the flux has increased, statistical analysis showed no significant differences between different fluxes in terms of CEC rejection.
Quinone-modified metal-organic frameworks MIL-101(Fe) as heterogeneous catalysts of persulfate activation for degradation of aqueous organic pollutants
Authors: Guo Huaisu , Guo Weilin , Liu Yang , Ren Xiaohua 
Published: July 2019

Abstract
In this work, quinone-modified metal-organic framework MIL-101(Fe)(Q-MIL-101(Fe)), as a novel heterogeneous Fenton-like catalyst, was synthesized for the activation of persulfate (PS) to remove bisphenol A (BPA). The synthetic Q-MIL-101(Fe) was characterized via X-ray diffraction, scanning electron microscope, Fourier transform infrared, electrochemical impedance spectroscopy, cyclic voltammetry and X-ray photoelectron spectroscopy. As compared to the pure MIL-101(Fe), Q-MIL-101(Fe) displayed better catalytic activity and reusability. The results manifested that the Q-MIL-101(Fe) kept quinone units, which successfully promoted the redox cycling of Fe3+/Fe2+ and enhanced the removal efficiency. In addition, the reaction factors of Q-MIL-101(Fe) were studied (e.g. pH, catalyst dosage, PS concentration and temperature), showing that the optimum conditions were [catalyst] = 0.2 g/L, [BPA] = 60 mg/L, [PS] = 4 mmol/L, pH = 6.79, temperature = 25 °C. On the basis of these findings, the probable mechanism on the heterogeneous activation of PS by Q-MIL-101(Fe) was proposed.
El fenómeno de los food trucks en la ciudad de Barranquilla, ¿éxito, fracaso o una simple moda?
Authors: Lama-Acosta Alex José , Ucros-Berrio Martha Cecilia , Silva-Guerra Harold 
Published: July 2019

Hablar de los food trucks hoy en día en Barranquilla, es casi como hablar del pasado, debido a la particularidad que caracteriza a los Barranquilleros de tomar hasta la comida como algo de moda, así como a todas las cosas que giraron en torno al fenómeno de los food trucks en la ciudad. Al no poder movilizarse libremente por las calles, debido a las restricciones de ley, el negocio de los food trucks se trasladó a las plazas de comidas de food trucks, parqueaderos habilitados para vender comida, en las cuales los precios del arriendo por metro cuadrado superaba considerablemente el precio de un arriendo en un centro comercial y el cual exigía una prima de ingreso alta para ingresar; sin garantizar un número de clientes por día y sin darle a los propietarios la libertad de vender lo que ellos querían, pues si en la plaza ya había un negocio de pizza no podía haber otro de pizza. Además, no resultaba nada fácil para personas sin experiencia y con poco capital operar en un espacio de 2x2, era un modelo que estaba destinado al fracaso.
An Intergenerational Information and Communications Technology Learning Project to Improve Digital Skills: User Satisfaction Evaluation
Authors: López Seguí Francesc , de San Pedro Marc , Aumatell Verges Eva , Simó Algado Salvador , Garcia Cuyàs Francesc 
Published: July 2019

Background
“Digital Partners” is an intergenerational information and communications technology learning project carried out in the municipalities of Vic and Centelles (Catalonia) from April to May 2018. Within the framework of the introduction of community service as a subject in secondary education, the Centre for Health and Social Studies (University of Vic) created a training space with 38 intergenerational partners (aged 14-15 years and >65 years), with the aim of improving the senior users’ digital skills in terms of use of smartphones and tablets, thus helping reduce the digital divide in the territory.

Objective
The aim of this paper is to evaluate the satisfaction of both junior and senior participants toward the intervention and to explore its main drivers.

Methods
Participants who volunteered to participate in the study were interviewed. Quantitative and qualitative data gathered in paper-based ad hoc surveys were used to assess participants’ satisfaction.

Results
The experience shows a broad satisfaction of both junior and senior users. The project’s strengths include the format of working in couples; randomly pairing individuals by operating system; the ability to practice with the device itself; individuals’ free choice to decide what they wish to learn, develop, or practice; and the availability of voluntary practice material that facilitates communication and learning. With regard to aspects that could be improved, there is a need to review the timetabling flexibility of meetings to avoid hurrying the elderly and to extend the project’s duration, if necessary.

Conclusions
This activity can serve to create mutual learning through the use of mobile devices and generate security and motivation on the part of the seniors, thus reducing the digital divide and improving social inclusion.