bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development of a 50K SNP array for whole-genome analysis and its application in the genetic localization of eggplant (Solanum melongena L.) fruit shape
Authors: Yu Chuying , Yang Qihong , Li Weiliu , Jiang Yaqin , Gan Guiyun , Cai Liangyu , Li Xinchun , Li Zhiqiang , Li Wenjia , Zou Min , Yang Yang , Wang Yikui 
Published: November 2024

IntroductionCurrent eggplant variety breeding is still mainly based on conventional methods, and there remains a lack of effective molecular breeding systems for complex traits controlled by multiple genes, such as yield and quality. To accelerate the research progress of eggplant genetics and molecular breeding, it is necessary to implement a genome-based breeding strategy.MethodsTherefore, in this study, a SNP array containing 50K liquid-phase probes was designed on the basis of the resequencing data of 577 eggplants.ResultsThe developed 50K liquid-phase probes were used to perform targeted capture sequencing on 12 eggplant lines, and the efficiency of probe capture exceeded 99.25%. Principal component, phylogenetic, and population structure analyses divided the 577 eggplants into 7 subgroups, and statistical analysis was performed on the fruit shape and color of the materials in the different subgroups. Further analysis of the geographical distribution of 428 Chinese eggplant materials revealed that the geographical regions of different subgroups were similar. The 50K SNP liquid-phase array was used to perform bulked- segregant analysis combined with whole-genome resequencing (BSA-seq) of fruit shape in the F2 population, which consisted of 1435 lines constructed with E421 as the maternal parent and 145 as the paternal parent. The BSA-seq data were located in the 78444173−84449348 interval on chromosome 3, with a size of 6 Mb, which was narrowed to 712.6 kb through fine mapping. Further sequence alignment and expression analysis revealed SmIQD14 as a candidate gene controlling eggplant fruit shape. The 50K SNP liquid-phase array can be widely used in future eggplant molecular breeding research.
The neural basis underlying the association between parents’ socioeconomic status and depressive symptoms among college students
Authors: Xiao Yao , Jiang Xinting , Li Yuan , Mao Yu , Zhou Duyi 
Published: November 2024

ObjectiveDepression is increasingly prevalent among adolescents, with parents’ socioeconomic status (SES) serving as significant predictors. Understanding the link between parents’ SES and college students’ depressive symptoms is of paramount concern. However, the neural basis linking the association between parents’ SES and students’ depressive symptoms still remains to be explored. In order to address this issue, this study aims to investigate the relationship between parents’ SES and students’ depressive symptoms, and the role of brain functional connectivity (FC) pattern in this relationship.MethodsIn this study, a total of 363 college students without a history of mental or neurological disorders underwent depressive symptoms assessment and resting-state functional magnetic resonance imaging scans. We used a connectome-based predictive modeling (CPM) approach to identify neural biomarkers of depressive symptoms.ResultsThe results indicate that there is a negative correlation between parents’ SES and students’ depression tendencies (Father’s education level and SDS: r  = −0.119, p &lt; 0.05; Mother’s education level and SDS: r  = −0.117, p &lt; 0.05), suggesting that students whose parents have a higher educational level are less likely to suffer from depression. Furthermore, a FC pattern that can significantly predict depressive symptoms outside of the body was identified (r  = 0.13, p &lt; 0.005), with most of the FCs belonging to the default mode network (DMN) and ventral attention network (VAN). Additionally, the FC pattern associated with depressive symptoms mediate the relationship between parents’ SES and depressive symptoms.ConclusionTherefore, we believe that improving the education levels of parents may have a practical effect in reducing depressive symptoms among adolescents.
Association of the neutrophil-to-platelet ratio with response to electroconvulsive therapy in adolescents with major depressive disorder
Authors: Geng Dandan , Wang Wenxin , Du Ning , Niwenahisemo Lisa Cynthia , Xu Heyan , Wang Yuna , Kuang Li 
Published: November 2024

BackgroundMajor depressive disorder (MDD) is one of the most serious mental disorders affecting adolescents worldwide. Electroconvulsive therapy (ECT) is widely acknowledged as a first-line treatment for severe depression, but the clinical response varies. Neutrophils and platelets are both related to the progression of MDD. The aim of this study was to investigate the correlation between the neutrophil-to-platelet ratio (NPR) during the acute phase and the effectiveness of ECT treatment.MethodsA total of 138 adolescent MDD patients who received ECT were included in the study. Neutrophil and platelet levels were obtained upon admission. At the same time, treatment response was the primary outcome measure, defined as a reduction of ≥ 50% in the HAMD-17 score from baseline to treatment endpoint, and the secondary outcome measure was remission of depression, defined as a HAMD-17 score ≤ 7.ResultsAfter receiving ECT, 103(74.6%) of all patients responded to treatment and 72(52.2%) achieved remission. Non-responders/non-remitters to ECT tended to have higher levels of NPR at baseline compared to ECT responders/remitters [Non-responder: 3.4 (2.5-4.8) vs 2.7 (2.2-3.5), P = 0.002; Non-remitter: 0.014 (0.011-0.017) vs 0.011 (0.008-0.015), P = 0.03]. In multiple logistic regression, high NPR (≥ 0.014) remained independently associated with ECT non-response/non-remission after adjusting for confounding factors [Non-responder: OR = 4.911, 95% CI (2.052 - 11.754), P &lt; 0.001; Non-remitter: OR = 2.704, 95% CI (1.262 - 5.796), P = 0.011].ConclusionHigh NPR correlates with poor ECT efficacy in adolescents with MDD, particularly among female and overweight patients.
A bibliometric analysis of mental health among high school students
Authors: Song Shilong , Yu Wenbing , Li Shuoqi , Sun Wenze , Fu Jiannan , Cheng Qi 
Published: November 2024

BackgroundIn recent years, with the increase in academic pressure and changes in social environment, especially after the outbreak of COVID-19, there has been a significant impact on the mental health of high school students. This trend, which is concerning, requires a systematic bibliometric analysis to develop effective preventive and remedial measures.ObjectiveThis study aims to identify and analysis the research hotspots, frontiers and emerging trends in the field of high school students’ mental health over the past two decades using CiteSpace software. These findings provide important insights that can shape future research agendas and guide targeted interventions to improve the mental health outcomes of this vulnerable group.MethodsThis study utilized the Web of Science Core Collection database as its data source to retrieve literature pertaining to high school students’ mental health from January 1, 2004, to January 1, 2023. The initial search yielded 1,764 relevant documents. After manually screening to exclude duplicates, conference proceedings, announcements, and irrelevant documents, a total of 1,748 relevant documents were retained. The research employed the CiteSpace 6.2.R4 tool to evaluate various bibliometric indicators of the included literature, including statistics on institutional and author publication volumes, as well as co-citation analysis.ResultsA total of 1,748 English-language documents were retrieved, showing an upward trend in publications on high school students’ mental health from 2004 to 2024. The research hotspots primarily focus on COVID-19 pandemic, depression, bullying, substance abuse, sexual behavior, Physical Education and their relationships with the mental health of high school students. Future research trends may focus on studies investigating the relationships between the use of electronic cigarettes, sleep disorders, internet addiction, and the mental health of high school students.ConclusionIn addition to the six major research hotspots of COVID-19 pandemic, Depression and stress, Suicidal ideation, Bullying, Sexual behavior and Physical education. Researches should pay more attention to the use of electronic cigarettes, sleep disorders, and Internet addiction among high school students.
Between compulsions and contagions: examining the protective role of OCD against COVID-19 in a large cohort study
Authors: Avni Chen , Sinai Dana , Toren Paz 
Published: November 2024

IntroductionSince the onset of the COVID-19 pandemic in 2020, a significant body of research has explored the impact of the virus and its preventative measures on mental health among individuals with OCD. However, to our knowledge, no study has been conducted to test whether the very behaviors considered symptomatic of OCD inadvertently offer a protective shield against COVID-19 infection.MethodsThis retrospective cohort study utilized the electronic health record database of Israel’s largest healthcare provider, Clalit Health Services (CHS), to compare patients with and without recorded OCD diagnoses in terms of the number of COVID-19 tests taken, hospitalizations, vaccination rates, and infection rates during and after different pandemic waves.ResultsThe OCD group had a slightly higher rate of positive COVID-19 tests compared to the control group (p&lt;0.001), but only since the easing of restrictions after the end of the fifth wave. The OCD group was also more likely to receive a third dose of the COVID-19 vaccine (p&lt;0.001).DiscussionOur findings suggest that OCD may not confer protection against COVID-19 and may even be associated with slightly higher infection rates, particularly in the post-restrictions period.
Mixed-methods formative evaluation of implementing an adapted suicide prevention treatment: Dialectical Behavior Therapy Skills Groups in the Veterans Health Administration
Authors: Decker Suzanne E. , Kroll-Desrosiers Aimee , Mattocks Kristin , Aunon Frances M. , Galliford Elizabeth , Doran Neal , Baird Scarlett , Rielage Jennifer K. , Ridley Josephine , Bannister Jenny , Giovannelli Thorayya S. , Landes Sara J. , Goodman Marianne , Walker Lorrie , DeRycke Eric , Shriver Chris , Spana Ethan , Honsberger Mark , Brown Hannah , Demirelli Stacey , Shest Elena , Martino Steve 
Published: November 2024

BackgroundPreventing veteran suicide requires addressing mechanisms driving suicidal behavior, such as emotion dysregulation. Dialectical Behavior Therapy Skills Groups (DBT-SG) are well established for reducing emotion dysregulation, improving coping skills, and in some studies, reducing suicide attempt, but will require implementation support to deliver DBT-SG and to test its effectiveness within the Veterans Health Administration (VHA).MethodsWe conducted a mixed-method developmental formative evaluation of DBT-SG at four VHA medical centers, guided by the Integrated Promoting Action on Research Implementation in Health Services (i-PARIHS) framework, as part of a hybrid effectiveness-implementation trial (Clinical trials ID, NCT05000749).ResultsQuantitative Organizational Reasons for Change Assessment data (n = 30 VHA staff) and qualitative data (n = 35 VHA staff) were merged, compared, and triangulated. Quantitative and qualitative data largely converged, showing favorable views of evidence supporting DBT-SG and strong enthusiasm for its potential to reduce veteran suicide attempt. Staff noted DBT-SG’s broad applicability to veterans. Staff were less optimistic about the inner context supporting DBT-SG implementation, commenting on how limited staffing could be a barrier despite leadership wanting to support suicide prevention.ConclusionsImplementation barriers to DBT-SG at VHA include limited staffing, despite staff enthusiasm. The next phase of this project will evaluate DBT-SG effectiveness in a randomized controlled trial.Clinical trials registrationhttps://clinicaltrials.gov/study/NCT05000749, identifier NCT05000749.
Association between oral health-related behaviors and quality of life of adolescents among three provinces in Northwest China
Authors: Hu Xiao , Wang Can , Gao Jianghong , Tian Jiangang , Li Lingling , Li Zhige , Guo Kaixin , Huang Ruizhe 
Published: November 2024

ObjectiveTo assess the oral health-related quality of life (OHRQoL) of adolescents in Northwest China, and to explore the relationship between sociodemographic characteristics, oral health-related behaviors and OHRQoL.MethodsA cross-sectional survey of adolescents aged 12–15 years in Shaanxi, Gansu province and Ningxia Hui Autonomous Region of Northwest China was conducted by stratified cluster random sampling. Oral examinations were performed with World Health Organization (WHO) standards, and the condition of crowns and periodontal was recorded. Adolescents' oral health-related behaviors and OHRQoL were collected by questionnaire. Chi-square test and binary logistic regression analysis were used to examine the relationship.ResultsA total of 7,648 subjects were included. The prevalence of low OHRQoL which defined as a score higher than 0, was 83.8%. A low OHRQoL was most prevalent in Gansu Province and least prevalent in Shaanxi Province. Younger (OR = 0.73, CI = 0.60–0.87), female (OR = 1.27, CI = 1.11–1.44), rural (OR = 1.44, CI = 1.21–1.72), and mother with less education (OR = 0.69, CI = 0.60–0.81) all showed statistically significant influence on teenagers' OHRQoL. From a behavior perspective, teens' OHRQoL was correlated with their frequency of sugar consumption (OR = 1.72, CI = 1.41–2.10), dental appointment rate (OR = 1.29, CI = 1.064–1.57), self-assessment of oral health (OR = 3.09, CI = 2.29–4.19), DMFT index (OR = 1.19, CI = 1.04–1.37), number of teeth calculus (OR = 1.20, CI = 1.01–1.43), and dental trauma (OR = 0.47, CI = 0.39–0.57) over the previous year; however, brushing their teeth was not statistically significant.ConclusionsGenerally speaking, oral health-related behaviors—such as eating more sugary foods and scheduling dental appointments within the last year—have a significant negative impact on the quality of life of adolescents in Northwest China. Female, and adolescents from families with low educational backgrounds are more likely to be affected by such behaviors in their daily lives.
A dyadic analysis of family adaptation among breast cancer patients and their spouses based on the framework of family stress coping theory
Authors: Ding Zhangyi , Fan Yarong , Zhong Gaoxiang , Zhang Xinmiao , Li Xichen , Qiao Yan , Cui Huixia 
Published: November 2024

BackgroundThe active coping strategies of family members can help breast cancer patients better handle the crisis, and family adaptation is a manifestation of the family's active coping with the crisis. In the study of breast cancer, a disease that predominantly affects women, we explored the influence of spouses on patients' family adaptation. This aspect has not been explored in previous studies.PurposeIn recent years, with the development of family stress coping theory, cancer coping styles have shifted from an individual focus to a whole-family approach. This shift has the potential to help families of cancer patients adapt to the crisis. This study aimed to explore the correlation between dyadic coping, family adaptation, and benefit finding in couples with breast cancer.MethodsUsing convenience sampling, the study included 325 pairs consisting of breast cancer patients and their spouses who attended breast surgery, oncology, and chemotherapy sessions between April and November 2023. The survey utilized the General Information Questionnaire for patients and spouses, the Dyadic Coping Scale, the Benefit Finding Scale, and the Family Adaptability and Cohesion Evaluation Scales. Data analysis was conducted using SPSS 25.0 and Amos 24.0 software.ResultsIn the actor effect of dyadic coping on family adaptation, the benefit finding of patients and their spouses played a mediating role. Regarding the partner effect (B = 0.019, 95% CI = 0.003–0.045, P &lt; 0.05), the dyadic coping of spouses indirectly affected the family adaptation of patients through the benefit findings of patients. The patient's dyadic coping can directly affect the spouse's family adaptation. The spouse's dyadic coping can influence the patient's benefit finding.ConclusionThere is a partial interaction between breast cancer patients and their spouses' dyadic coping, benefit finding, and family adaptation. Therefore, clinical staff should promptly identify patients and spouses with poor coping abilities and provide them with positive psychological interventions to enhance the dyadic coping abilities of both partners and assist them in overcoming the problems encountered during the treatment process, ultimately helping them better cope with family crises.
Participation of teenagers with vision or motor impairments in leisure activities: a qualitative study
Authors: Veldhorst Carlijn , Wijnen Marjolein , Kef Sabina , Vervloed Mathijs P. J. , Steenbergen Bert 
Published: November 2024

PurposeParticipation in everyday life activities is important for the development of children and is an important topic in rehabilitation practices. This qualitative study aimed to unveil the perspectives and experiences of teenagers with vision impairments (VIs) or motor impairments (MIs) regarding their participation in leisure activities.Materials and methods13 teenagers with VIs and 12 teenagers with MIs (age range: 11–15 years) participated in this study. Data were collected using semi-structured interviews. Verbatim transcripts were analyzed following the steps of the phenomenological approach.ResultsA total of 623 significant statements were identified and assigned to 221 meaning units. Finally, 13 themes emerged. Teenagers with VIs and MIs shared many experiences and perspectives regarding participation in leisure activities.ConclusionsTeenagers reported that they can sufficiently indicate what they experience as pleasant and sufficient considering their participation, as well as the challenges they encountered, such as their impairment, limited transport possibilities, or concerns from parents. Overall, teenagers with VIs or MIs were generally satisfied with the degree and frequency of their participation in leisure activities and felt sufficiently involved.
Exploring the relationship between website quality and equity in living donor kidney transplant
Authors: McElroy Lisa M. , Obayemi Joy E. , Shaw Brian I. , Park Christine , Caddell Keenan , Davis LaShara A. , DePasquale Nicole , Mohottige Dinushika , Boulware L. Ebony 
Published: November 2024

BackgroundHealth system websites are important resources to guide health care decisions and may be useful tools to improve racial equity in access to living donor kidney transplant (LDKT).MethodsWe performed a cross-sectional study of adult LDKT programs in the United States. We created an assessment tool for website quality across three domains: accessibility (access to LDKT specific information from the transplant center website), readability (ease of reading and clarity), and educational content (appropriateness and presentation of information, LDKT-specific content, program-specific characteristics, and adherence to equity-centered principles of web design).ResultsAmong the 185 transplant center websites reviewed, only 14.6% of LDKT sites could be accessed directly from the transplant center webpage. The median suitability assessment of materials (SAM)—a validated measure of website content for chronic kidney disease (CKD)—was 45 out of 86 (IQR 4) and the median Flesch-Kincaid grade level and ease score were 9.1 (IQR 0.8) on a scale of 0–18 and 51.2 (IQR 5) on a scale of 0–100, respectively.ConclusionThese results indicate that LDKT websites are currently not available, accessible, and understandable for many potential transplant candidates and donors. Optimizing the content and design of transplant center websites may be a promising and effective strategy for improving equity in access to LDKT.
Fluid balance of female para hockey players during simulated competition
Authors: Gavel Erica H. , Rae Samantha , Logan-Sprenger Heather M. 
Published: November 2024

PurposeThe purpose of this study was to characterize the hydration habits and fluid balance of female para-ice hockey players.MethodsFifteen players [5 defense (D), 8 forwards (F), and 2 goalies (G)] volunteered to participate in the study (age: 26.3 ± 10.9 y; ht:155 ± 11 cm; arm length: 65 ± 8 cm; leg length: 88 ± 11 cm; trunk length: 66 ± 14 cm). Players were weighed pre- and postgame, while fluid intake and individual playing time (PT) was monitored throughout the game.ResultsOn average, athletes arrived hydrated to the game (USG 1.019 ± 0.006) with 40% of players arriving dehydrated (USG &gt;1.020). Mean playing time for forwards was 11:47–28:49 min:s (18:52 ± 5:48 min:s) and for defence 13:10–18:24 min:s (15:10 ± 2.05 min:s). Sweat loss was 0.96 ± 0.64 L (0.10–2.50 L) which exceeded net fluid intake (0.61 ± 0.37 L). Mean BM loss was 0.44 ± 0.9% (−2.1 to +0.9%) with 4 of 15 players (2 D, 1 F, 1 G) losing between 1.4 and 2.1% BM. Players preferred to drink water during the game compared to a carbohydrate electrolyte solution.Conclusion60% of athletes arrived hydrated to the game and drank enough fluid to prevent a BM loss &lt;1%. Of note is that 40% of players arrived at the arena mildly dehydrated based on USG, and despite abundant opportunities to drink fluid during the game, 25% of players lost &gt;1.3% BM due to sweat loss which may compromise physical and cognitive performance.
Cardiac cement embolism and asymptomatic pulmonary embolism caused by percutaneous vertebroplasty for osteoporotic vertebral fracture: a case report
Authors: Yang Yang , Fei Qi , Long Gong Qian , Bo Wu , Jun Feng Ye , Rong Zhang , Kui Huang 
Published: November 2024

BackgroundAs society ages, the incidence of osteoporotic vertebral compression fractures steadily rises. Procedures like percutaneous kyphoplasty (PKP) and percutaneous vertebroplasty (PVP) have proven effective in significantly relieving pain in patients with these fractures. While PKP and PVP are minimally invasive, complications can still occur. However, most complications are not clinically significant, with cement leakage being the most common.Case presentationWe present the case of a patient with an osteoporotic vertebral compression fracture who underwent percutaneous kyphoplasty (PKP) and percutaneous vertebroplasty (PVP). On the night following the procedure, the patient experienced transient discomfort in the chest, which resolved on its own. A chest CT scan the next day revealed a 5 cm arc-shaped high-density shadow near the right atrium, along with multiple high-density lung spots. After consulting with cardiothoracic surgery, interventional vascular surgery, and radiology experts, and discussing options with the patient and their family, a thoracotomy was recommended to remove the bone cement from the heart. However, the attempt was unsuccessful. Despite this, the patient made a good recovery and was successfully discharged.ConclusionsVascular leakage of bone cement is a potentially life-threatening complication of PKP/PVP, and it warrants careful attention.