bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development and content validity of the Abilitator – a self-report questionnaire on work ability and functioning aimed at the population in a weak labour market position
Authors: Wikström Miia , Anttila Heidi , Savinainen Minna , Kouvonen Anne , Joensuu Matti 
Published: October 2019

Abstract
Background The unemployed have lower work ability and poorer health than the employed. This situation deteriorates when unemployment continues. The long-term unemployed often have co-morbidities and face many other challenges. This increases the need for a multidimensional assessment of work ability and functioning in different service settings. In this study, we describe the development and analyse the content validity of the Abilitator, a self-report questionnaire on work ability and functioning for those in a weak labour market position. Methods The Abilitator was developed in 2014–2017. Its construct was assessed by the members of academic expert panels (n=30), practical expert panels of service actors (n=700) and target group clients (n=28). The structure and the content of the questionnaire was co-developed in 29 workshops and adjusted twice based on the expert panels’ feedback. The Abilitator was also implemented among target group clients (n=3360) in different services and projects. During its development the Abilitator was linked to the International Classification of Functioning, Disability and Health (ICF). The content validation process followed the guidelines recommended by the Consensus-based Standards for the selection of health Measurement Instruments (COSMIN) panel. Results The construct of the Abilitator combines the multidimensional and bio-psycho-social models of work ability and functioning. It also includes aspects of social inclusion and employability. It evaluates social, psychological, cognitive and physical functioning, and the ability to cope with everyday life. The content of these concepts was validated by the academic and practical expert panels. The Abilitator’s 79 ICF codes covered 50% of the Generic, 73% of the Brief Vocational Rehabilitation, and 17% of the Minimal Environmental ICF Core Sets. When compared with the Work Ability Index (WAI) and the World Health Organization Disability Assessment Schedule (WHODAS 2.0), the direct equivalences of the ICF codes were 29% and 39%, respectively. Conclusions The Abilitator covers the relevant aspects sufficiently comprehensively to enable the assessment of the overall work ability and functioning of the population with weak position in the labour market.
Caring Behavior And Associated Factors Among Nurses Working In Jimma University Specialized Hospital, Oromia, South West Ethiopia, 2019
Authors: Oluma Adugna , Abadiga Muktar 
Published: October 2019

Abstract
ABSTRACTBACK GROUND: Caring behaviors are actions concerned with the wellbeing of the patients such as sensitivity, comforting, attentive listening, honest and nonjudgmental acceptance. Nurses have an opportunity to convey caring and feeling being cared through their behavior. Behavior associated with caring has a paramount role in linking nursing interaction to the client in experiences but, the concept is ambiguous and elusive toward different scholars to reach on common understanding which is a myth in dealing with caring behavior. Only a few studies have been done on the caring behavior and associated factors globally, and there is a limitation of study done in Ethiopia particularly in this study area. Therefore; the purpose of this study was to assess caring behavior and its associated factors among nurses working in Jimma University specialized hospital, southwest Ethiopia.METHODS: The institutional-based cross-sectional study design was conducted on a sample of 224 nurses working in Jimma university specialized hospital from March 20-April 20, 2019. Data were collected by self-administered questionnaire. Descriptive statistics including frequency table, mean, standard deviation and percentage were employed. Bivariate and multiple linear regression analysis was used with regression coefficient (β), coefficient of the determinant (R²), CI 95% and p<0.05 were used for statistical significance.RESULTS: The overall proportion of nurses caring behavior was 80.3% which was mostly measured in terms of professional –technical (82.9%) and psychosocial (81.3%) dimension. Job satisfaction as personal satisfaction (beta=1.12, p=0.00), professional satisfaction, (beta=1.07, p=0.00), joint participation in caring process (beta=0.58, p=0.00,) satisfaction with nurse management (beta=0.85, p=00) were significantly associated with caring behavior.CONCLUSION: The proportion of nurses who had a high perception of caring behavior was found to be lower. Thus, all predictors have their own effect on enhancing job satisfaction, improving and creating conducive management and working environment to increase caring behavior. Further comparative studies involving a multidisciplinary and patient point of view were recommended.KEYWORDS: Caring, Caring behavior, Nurses, Jimma, Ethiopia
UTILIZATION AND ASSOCIATED FACTORS OF EMERGENCY CONTRACEPTION AMONG WOMEN SEEKING ABORTION SERVICES IN HEALTH INSTITUTIONS OF DESSIE TOWN, NORTH EAST ETHIOPIA,2018
Authors: Feleke Asres Eshetie , Nigussie Tewdros Seyoum , Debele Tibeb Zena 
Published: October 2019

Abstract
Objective

The aim of the study was to assess utilization and associated factors of emergency contraception among women seeking abortion services in Health Institutions of Dessie Town, North East Ethiopia, 2018.Results

Among the interviewed 784 women 400(51%) utilized emergency contraception. Women’s age [AOR: 2.10, (95% CI 1.200, 3.671)], residence [AOR: 2.02 (95% CI1.273, 3.218], marital status [AOR: 1.71, (95%CI: 1.176, 2.485)], knowledge of emergency contraception [AOR: 5.66, (95%CI: 3.976,8.070)], and attitude towards emergency contraception [AOR: 2.75(95%CI: 1.946, 3.881)] were significantly associated factors with the utilization of emergency contraceptives. The emphasis of health education on emergency contraceptives shall focus on those women who are from the rural area, older and married women.
Integrated analysis of miRNA-seq and mRNA-seq reveals immune related miRNA-mRNA regulation network in the DHAV-3-infected duckling liver
Authors: Wu Fengyao , Lu Fengying , Fan Xin , Chao Jin , Liu Chuanmin , Pan Qunxing , Sun Huawei , Zhang Xiaofei 
Published: October 2019

Abstract
Background: Duck hepatitis A virus type 3 (DHAV-3) is one of the most harmful pathogens in the duck industry. However, the molecular mechanism underlying DHAV-3 infection in ducklings is remain poorly understood. To elucidate the genetic regulatory network for miRNA-mRNA and the signaling pathways involved in DHAV-3 infection in ducklings, we conducted global miRNA and mRNA expression profiling of duckling liver tissues infected with lethal DHAV-3 using high-throughput sequencing. Results: We found 156 differentially expressed miRNAs (DEMs) and 7717 differentially expressed miRNAs (DEGs) between mock-infected and DHAV-3-infected duckling livers. A total of 19,606 miRNA-mRNA pairs with negatively correlated expression patterns were identified in miRNA-mRNA networks constructed on the basis of these DEMs and DEGs. Moreover, immune-related pathways including the cytokine-cytokine receptor interaction, apoptosis, Toll-like receptor, Jak-STAT, and RIG-I-like receptor signaling pathway were significantly enriched through analyzing functions of mRNAs in the network in response to DHAV-3 infection. Besides, apl-miR-32-5p, apl-miR-125-5p, apl-miR-128-3p, apl-miR-460-5p, and novel-m0012-3p were identified as potential regulators in the immune-related signaling pathways during the DHAV-3 infection. Conclusions: To our knowledge, this is the first report on integrated analysis of miRNA-seq and mRNA-seq in DHAV-3-infected ducklings. The results indicated the important roles of miRNAs in regulating immune response genes and revealed the immune related miRNA-mRNA regulation network in the DHAV-3-infected duckling liver. Our findings may provide valuable information to further investigate the roles of miRNAs and their target genes in DHAV-3 replication and pathogenesis; additionally, they may offer clues for further understanding host-virus interactions.
Transcriptomic dynamics changes in development of carmine radish (Raphanus sativus L.) fleshy roots using RNA-seq method
Authors: Gao Jian , Luo Mao , Liu Yi , Chen Fabo , Peng Hua , Li Wenbo 
Published: October 2019

Abstract
Radish ( Raphanus sativus L.), belonging to biennial root vegetable crop of Brassicaceae family, is an economically important vegetable crop with an edible taproot. Recently, most of differential expressed genes associating with anthocyanin biosynthesis have been identified in most of important fruit crops. However, transcriptome analysis of anthocyanin biosynthesis and expression of anthocyanin biosynthesis related genes in ‘Hongxin’ radish have not been fully investigated. Here, based on results from HPLC analysis, young fleshy roots obtained from the dynamics development stage of fleshy roots in carmine radish ‘Hongxin 1’ was used for RNA-Seq, including fleshy roots from seedling stage (SS), initial expansion (IE), full-expansion (FE), bolting stage (BS), initial flowering stage (IFS); full-bloom stage (FBS) and podding stage (PS). Subsequently, the putative candidate genes involved in the dynamics development stage of fleshy roots in carmine radish were identified. After that, DGE (differential gene expression) profile analysis was used to identify the pupative transcripts, compared with fleshy roots from seedling stage (SS). In addition, co-modulated DEGs (Common DEGs in the dynamic growing stages of fleshyroot in carmine radish) were also identified, from which most DGEs were more likely to participate in anthocyanin biosynthesis, including two transcription factors RsMYB and Rs RZFP . In addition, some related proteins e.g. RsCHS , RsDFR , RsANS , RsF’3H , RsF3GGT1 , Rs3AT1 , glutathione S-transferase F12, RsUFGT78D2-like and RsUDGT-75C1-like were significantly contributed to the regulatory mechanism during anthocyanin synthesis in the development stage of fleshy roots. Furthermore, GO terms comprised of “anthocyanin-containing compound biosynthetic process” and “anthocyanin-containing compound metabolic process” were commonly overrepresented in the other dynamics growing stages of fleshy roots after initial expansion of fleshy roots. Moreover, these results indicated that five significantly enrichment pathways of DEG were identified for the dynamics growing stages of fleshy roots in carmine radish, including Flavonoid biosynthesis, Flavone and flavonol biosynthesis, Diterpenoid biosynthesis, Anthocyanin biosynthesis, as well as Benzoxazinoid biosynthesis. These results will expand our understanding of complex molecular mechanism of the putative candidate genes involved in the dynamics development stage of fleshyroot in carmine radish.
Evaluating the effects of an exercise program (Staying UpRight) for older adults in long-term care on rates of falls: study protocol for a randomised controlled trial
Authors: Taylor Lynne , Parsons John , Taylor Denise , Binns Elizabeth , Lord Sue , Edlin Richard , Rochester Lynn , Din Silvia Del , Klenk Jochen , Buckley Christopher , Cavadino Alana , Moyes Simon A , Kerse Ngaire 
Published: October 2019

Abstract
BackgroundFalls are two to four times more frequent amongst long-term care (LTC) than community-dwelling older adults and have deleterious consequences. It is hypothesized that a progressive exercise program targeting balance and strength will reduce falls rates when compared to a seated exercise program and do so cost effectively.Methods/DesignThis is a single blind, parallel-group, randomized controlled trial with blinded assessment of outcome and intention-to-treat analysis. LTC residents (age ≥65 years) will be recruited from LTC facilities in New Zealand. Participants (n= 528 total; with a 1:1 allocation ratio) will be randomly assigned to either a novel exercise program (Staying UpRight), comprising strength and balance exercises designed specifically for LTC and acceptable to people with dementia, (intervention group) or a seated exercise program (control group). The intervention and control group classes will be delivered for 1 hour twice weekly over 1 year. The primary outcome is rate of falls (per 1000 person years) within the intervention period.Secondary outcomes will be risk of falling (the proportion of fallers per group), falls rate relative to activity exposure, hospitalisation for fall-related injury, change in gait variability, volume and patterns of ambulatory activity and change in physical performance assessed at baseline, 6 and 12 months. Cost effectiveness will be examined using intervention and health service costs. The trial commenced recruitment on 31 November 2018.DiscussionThis study evaluates the efficacy and cost effectiveness of a progressive strength and balance exercise program for aged-care residents to reduce falls. The outcomes will aid development of evidenced-based exercise programs for this vulnerable population.Trial registrationAustralian New Zealand Clinical Trials Registry ACTRN12618001827224. Registered on November 9 2018; Universal trial number U1111-1217-7148
Positive deviance for dual-method promotion among women in Uganda: Study protocol for a cluster randomized controlled trial
Authors: Kosugi Hodaka , Shibanuma Akira , Kiriya Junko , Ong Ken Ing Cherng , Mucunguzi Stephen , Muzoora Conrad , Jimba Masamine 
Published: October 2019

Abstract
Background Dual-method use is known as the most reliable protection against unintended pregnancies and sexually transmitted infections, including HIV. However, it is not commonly used in sub-Sharan Africa, especially among women using highly effective contraceptives. This article describes a protocol to evaluate the effect of an intervention formulated under the positive deviance approach for promoting dual-method use in Uganda.Methods One hundred women will be interviewed using a structured questionnaire to find those practicing dual-method use. Then, in-depth interviews will be conducted with all women using dual-method and ten women using only highly effective contraceptives to identify their unique practice. Then, a cluster randomized controlled trial will be conducted to examine the effect of an intervention formulated under the positive deviance approach on dual-method uptake and adherence. Twenty health facilities will be randomized to an intervention or control arm, and 480 women will be enrolled in each group. The participants will be followed up for eight months.Discussion This trial focuses on women who already adapted dual-method use and identifies their unique solutions to promote dual-method use. This trial could tackle barriers for dual-method use, which expert outsiders may fail to recognize, by analyzing and promulgating their unique behaviors. This study could provide evidence that the positive deviance approach can address unintended pregnancies and sexually transmitted infections as well as other health problems which usual approaches have failed to address.
College Students Responding to the Chinese version of Cardiff Fertility Knowledge Scale Show Deficiencies in Their Awareness: A cross-sectional survey in Hunan, China
Authors: Zhou Yanhui , Wang Ting , Cui Yanhui , Chen Mingzhu , Fu Jingxia , Luo Yang 
Published: October 2019

Abstract
Background: The worldwide total fertility rate has declined, and the age pattern of childbearing and marriage has changed markedly. This trend has affected the social and economic development, especially fertility health. Previous studies indicated that incorrect perceptions of fertility can influence the fertility choice, and postponing parenthood is associated with an increase risk of higher maternal age in direction of more pregnancy-related complications. However, little is known in China, which has a low total fertility rate. Hence, understanding the knowledge about fertility is greatly needed. The aim was to investigate the knowledge about fertility issues among college students, the related influence factors, the way of acquiring fertility knowledge, the relationship between fertility knowledge and fertility intention. Methods : An online cross-sectional survey among Chinese college students was conducted in Hunan province from March to April in 2018. A total of 867 college students from three comprehensive universities responded to a poster invitation utilizing the Chinese version of the Cardiff Fertility Knowledge Scale (CFKS-C). Results: The average percent correct score on the CFKS-C was 49.86% (SD=20.817), with greater knowledge significantly related to living in a city district, currently having a stable relationship, majoring in medicine/health, the year 4 or above of study, and intention to have children (all p ＜0.05). The lowest score was “having a healthy lifestyle makes you fertile (false)”, the highest score was “a woman is less fertile after the age of 36 years (true)”. And then, 81.88% participants said that they would like to have children, the average score of the importance of childbearing was 6.34 (SD=2.714), female’s score was lower than male’s ( p =0.001). A small positive relationship was observed between the CFKS-C and the importance of childbearing ( r =0.074, p =0.035). Respondents said they gained most of their knowledge from the media and internet (41.36%) and schools (38.25%). Conclusion: The college students have a modest level of fertility knowledge, a relatively low intention to have a child, and deficiencies in fertility health education. Key words: Fertility knowledge; Fertility intention; Childbearing; College students; Awareness;
Trends in the incidence of diabetes mellitus: results from the Global Burden of Disease Study 2017 and implications for diabetes mellitus prevention
Authors: Liu Jinli , Ren Zhen-Hu , Qiang Hua , Wu Jine , Shen Mingwang , Zhang Lei , Lyu Jun 
Published: October 2019

Abstract
Backgroud:Diabetes mellitus is a common chronic disease and a severe public health issue. The incidence trends for type 1 diabetes (TIDM) and type 2 diabetes (T2DM) have rarely been studied on a global scale. We aimed to determine the temporal and geographical trends of diabetes globally. Methods:We collected detailed information on diabetes during 1990-2017 based on the 2017 Global Burden of Disease Study and calculated the estimated annual percentage changes (EAPCs) in age-standardized incidence rate (ASR) of diabetes mellitus according to sex, region, and disease type. Results:The incidence of diabetes mellitus increased by 102.9% worldwide, from 11,303,084 cases in 1990 to 22,935,630 cases in 2017, while the ASR increased from 233.6 per 100,000 person-year (py) to 284.6 per 100,000py [EAPC=0.87, 95% confidence interval (CI):0.79,0.96]. The global ASRs of T1DM and T2DM demonstrated significantly increasing trends during 1990-2017, with EAPC of 0.34(95% CI:0.30,0.39) and 0.89 (95% CI:0.80,0.97), respectively. The incidence trends also varied considerably by regions and countries. The increase in ASR was largest in high-SDI regions (EAPC=1.05, 95% CI:0.92,1.17) and smallest in low-SDI regions (EAPC=0.79, 95% CI:0.71,0.88).The EAPC of diabetes mellitus showed a declining trend in countries with a high human development index (HDI). Conclusions: Diabetes mellitus is a worldwide public health problem. Both the number of cases and ASR of diabetes mellitus increased significantly during 1990-2017 worldwide, but the temporal trends varied markedly across regions and countries.In addition, the ASR of T1DM differed with latitude and the farther away from the equator, the higher the ASR in 2017.
The Reduction in CD8+PD1+ T Cells in Liver Histological Tissue is Related to Pegylated IFN-α Therapy Outcomes in Chronic Hepatitis B Patients
Authors: Liu Ruyu , Chen Yanhui , Guo Jiang , Li Minghui , Lu Yao , Zhang Lu , Shen Ge , Wu Shuling , Chang Min , Hu Leiping , Hao Hongxiao , Zhang Henghui , Xie Yao 
Published: October 2019

Abstract
Background and Aim Antiviral therapy for patients with immune-active chronic hepatitis B (CHB) should be adopted to decrease the risk of liver-related complications. While antiviral therapy outcomes of PEG-IFN-α vary in different CHB patients. We aimed to identify the factors influencing antiviral therapy outcomes in CHB patients who received PEG-IFN-α therapy.Methods Thirty-two CHB patients who received PEG-IFN-α therapy were enrolled in this study. All of the patients underwent two liver biopsies at baseline and 6 months later. CD8 + T cells, CD4 + T cells, CD68 + mononuclear cells, and PD-1 levels in 64 liver biopsy specimens were tested via immunofluorescence.Results CD8 + T cells in 32 CHB patients’ liver tissue significantly decreased after 6 months of PEG-IFN-α therapy (p<0.01). CD8 + PD1 + T cells significantly decreased after 6 months of PEG-IFN-α treatment in the FIER (fibrosis and inflammation response with HBeAg seroconversion) group (p<0.05), while CD8 + PD1 - T cells had no significant difference. However, in the FIENR (no fibrosis and inflammation response and HBeAg seroconversion) group, CD8 + PD1 - T cells significantly decreased after 6 months of PEG-IFN-α treatment (p<0.05), while CD8 + PD1 + T cells had no significant difference. CD68 + mononuclear cells at baseline were higher in the FIRENR (fibrosis and inflammation response without HBeAg seroconversion) group than the FIENR (no fibrosis and inflammation response and HBeAg seroconversion) group.Conclusions The reduction in CD8 + PD1 + T cells in liver tissue was critical for patients who responded to PEG-IFN-α therapy. High levels of CD68 + mononuclear cells at baseline might be associated with fibrosis and inflammation response to PEG-IFN-α therapy.
Preoperative use of alpha-1 receptor blockers in male patients undergoing extracorporeal shock wave lithotripsy for a ureteral calculus: a retrospective cohort study
Authors: Yoshioka Takashi , Omae Kenji , Kawada Tatsushi , Inoue Yosuke , Sugimoto Morito , Oeda Tadashi , Uehara Shinya , Araki Motoo , Fukuhara Shunichi 
Published: October 2019

Abstract
Purpose To characterize the preoperative use of alpha-1 adrenergic receptor (AR) blockers and investigate its impact on the outcome of single-session extracorporeal shock wave lithotripsy (SWL) for a ureteral calculus in male patients. Methods We conducted a retrospective single-center cohort study involving 193 patients who underwent SWL for a single ureteral calculus between 2006 and 2016. We reviewed their medical records to obtain the data on the preoperative use of alpha-1 AR blocker and, if any, the reason for the prescription. The primary outcome was treatment success after single-session SWL, defined as complete stone clearance or residual fragments <4 mm in size by X-ray imaging. We performed a multivariable logistic regression analysis adjusting for clinically important confounders to examine the association between preoperative use of alpha-1 AR blockers and the treatment success of SWL. We further analyzed this association according to the reason for the prescription. Results Among the 193 patients, 15 (7.8%) were taking an alpha-1 AR blocker preoperatively with 8 (4.1%) for medical expulsive therapy (MET) and 7 (3.7%) for the treatment of benign prostatic hypertrophy (BPH). A multivariate analysis showed that the preoperative use of alpha-1 AR blocker was a significant negative predictor for treatment success of SWL (adjusted odds ratio [aOR] 0.17; 95% confidence intervals [CI], 0.04–0.74). Moreover, the use of alpha-1 AR blocker for MET, but not for BPH, was associated with lower rate of successful treatment (aOR 0.14 and 0.23; 95% CI, 0.02-0.90 and 0.03-1.97, respectively). Conclusions Our findings suggest that the preoperative use of alpha-1 AR blocker, especially for MET, was a negative predictor for treatment success of SWL in male patients with a single ureteral calculus. Clinicians should pay more attention to the preoperative drug use in determining an appropriate stone therapy modality.