bluuebunny/crossref_metadata_2025_split huggingface dataset:
Anti‐epidermal growth factor receptor therapy concurrently with induction chemotherapy in locoregionally advanced nasopharyngeal carcinoma
Authors: Peng Hao , Tang Ling‐Long , Liu Xu , Chen Lei , Li Wen‐Fei , Mao Yan‐Ping , Zhang Yuan , Liu Li‐Zhi , Tian Li , Guo Ying , Sun Ying , Ma Jun 
Published: March 2018

Little is known about the efficacy and toxicity of anti‐epidermal growth factor receptor therapy concurrently with induction chemotherapy (IC) in locoregionally advanced nasopharyngeal carcinoma (LA‐NPC). The present study aimed to address this question. We identified 2848 patients with newly diagnosed LA‐NPC receiving IC between January 2012 and May 2015. The propensity score matching (PSM) method was used to balance various factors and to match patients. Survival outcomes and toxicities between different groups were compared. In total, 596 patients were selected at a 1:3 ratio, with 149 in the IC + CTX/NTZ group and 447 in the IC alone group. The 3‐year disease‐free survival, overall survival, distant metastasis‐free survival and locoregional relapse‐free survival rates for IC + CTX/NTZ vs IC alone were 84.3% vs 75.2% (P = .059), 94.0% vs 87.9% (P = .053), 88.0% vs 84.9% (P = .412) and 93.3% vs 88.2% (P = .242). Multivariate analysis established a treatment group (IC vs IC + CTX/NTZ) as a prognostic predictor for DFS (hazard ratio [HR], 1.497; 95% confidence interval [CI], 1.016‐2.206; P = .041) and OS (HR, 1.984; 95%, CI, 1.023‐3.848; P = .043). Grade 3‐4 skin reaction (15.4% vs 0.4%, P < .001) and mucositis (10.1% vs 2.7%, P < .001) were more common in the IC + CTX/NTZ group than that in the IC alone group. Our findings suggested that CTX/NTZ in combination with IC may be a more effective and promising strategy for patients with LA‐NPC treated with intensity‐modulated radiotherapy.
Synthesis and effect of a new Terbium gibberellic complex on the histopathological alteration induced by Gibberellic acid on liver and kidney of mice Mus musculus
Authors: Seleem Amin A. , Hussein Belal H. M. 
Published: March 2018

The objective of this study was to synthesize Gibberellic lanthanide complex and evaluate its biological activity to reduce the Gibberellic acid toxicity on liver and kidney. The new bis(Gibberellic)‐nitro‐terbium(III) complex was characterized by different analytical methods: elemental analyses, UV–Vis, molar ratio, fluorescence, FT‐IR, and TGA‐DTA measurements. Thirty newborns were classified into three groups control, Gibberellic acid, and Terbium gibberellic acid complex. Livers and kidneys of studied groups proceed for general histology and immunohistochemical staining of Cyr61, cytochrome C, and TNFR2. From the absorption titration measurements, the binding constants of DNA with Tb(III)‐(GA)2 complex and free ligand were found to be 3.9 × 104 and 2.1 × 103 m−1, respectively, with the stoichiometry of 1:1. Hypochromism was observed from the absorption titration experiment which indicates the intercalation of Tb(III)‐(GA)2 complex between the base pairs of DNA. Gibberellic acid‐treated group showed alteration in the histological picture of livers and kidneys that accompanied with the reduction in the expression of Cyr61, cyt C, and TNFR2. The amelioration was observed in Gibberellic acid complex with Terbium group. The study concluded that Terbium gibberellic complex is less dangerous effects than Gibberellic acid alone.
Discovery of novel pyrrolopyrimidine/pyrazolopyrimidine derivatives bearing 1,2,3‐triazole moiety as c‐Met kinase inhibitors
Authors: Wang Linxiao , Liu Xiaobo , Duan Yongli , Li Xiaojing , Zhao Bingbing , Wang Caolin , Xiao Zhen , Zheng Pengwu , Tang Qidong , Zhu Wufu 
Published: March 2018

Six series of pyrrolo[2,3‐d]pyrimidine and pyrazolo[3,4‐d]pyrimidine derivatives bearing 1,2,3‐triazole moiety were designed and synthesized, and some bio‐evaluation was also carried out. As a result, four points can be summarized: Firstly, some of compounds exhibited excellent cytotoxicity activity and selectivity with the IC50 values in single‐digit μm level. In particular, the most promising compound 16d showed equal activity to lead compound foretinib against A549, HepG2, and MCF‐7 cell lines, with the IC50 values of 4.79 ± 0.82, 2.03 ± 0.39, and 2.90 ± 0.43 μm, respectively. Secondly, the SARs and docking studies indicated that the in vitro antitumor activity of pyrrolo[2,3‐d]pyrimidine derivatives bearing 1,2,3‐triazole moiety was superior to the pyrazolo[3,4‐d]pyrimidine derivatives bearing 1,2,3‐triazole moiety. Thirdly, three selected compounds (16d, 18d, and 20d) were further evaluated for inhibitory activity against the c‐Met kinase, and the 16d could inhibit the c‐Met kinase selectively by experiments of enzyme‐based selectivity. What is more, 16d could induce apoptosis of HepG2 cells and inhibitor the cell cycle of HepG2 on G2/M phase by acridine orange staining and cell cycle experiments, respectively.
Parenting style impacts cognitive and behavioural outcomes of former preterm infants: A systematic review
Authors: Neel M. L. M. , Stark A. R. , Maitre N. L. 
Published: March 2018

AbstractWe sought to evaluate published evidence in aggregate regarding the impact of parenting style on the cognitive and behavioural outcomes of former preterm infants. We searched 5 databases using germane MeSH terms. Parenting style was defined as any descriptor of parenting using ≥2 dimensions on published parenting axes. We evaluated studies for quality of evidence and strength of recommendations using standardized tools and categorized summative recommendations by parenting axis and child outcome. Twenty‐seven articles met our inclusion criteria. Parental responsivity is the only parenting axis strongly associated with both improved child cognition and behaviour. Parental demandingness is associated only with improved child cognition, and parental warmth and rejection are associated only with child behaviour. Parental coercion is not associated with subsequent child outcomes. Parental responsivity may be essential in optimizing neurodevelopment in former preterm infants. More targeted studies are needed to inform this relationship and identify opportunities for intervention.
“Not such a kid thing anymore”: Young adults' perspectives on transfer from paediatric to adult cardiology care
Authors: Catena G. , Rempel G. R. , Kovacs A. H. , Rankin K. N. , Muhll I. V. , Mackie A. S. 
Published: March 2018

AbstractBackgroundTransfer of adolescents with congenital heart disease from paediatric cardiology providers to specialized adult congenital heart disease (ACHD) care providers is becoming a standard practice. However, some paediatric cardiologists continue to provide care for their patients into adult life. Little is known about the perspectives of young adult patients who have been transferred to ACHD clinics versus those who continue to receive their cardiology care in paediatric settings.MethodsContent and thematic analysis of structured telephone interviews with 21 young adults age 18–25 (13 transferred to ACHD clinic and 8 who had not transferred) was conducted to identify similarities and differences in patient characteristics of those in ACHD versus paediatric settings.ResultsThere were no appreciable differences in gender, age, heart disease type, and independence between those transferred to ACHD care versus those not transferred. Participants in both groups were aware of differences between the paediatric and ACHD care settings and providers, with some favouring the familiarity offered by the paediatric setting and providers. Participants had varying views on parental involvement in their care; most of them had attended clinic appointments on their own. Those who had transferred to ACHD care acknowledged that it would take time to adjust to new relationships. Positive perspectives on actual or anticipated transfer to ACHD care included a growing sense of autonomy and responsibility, as well as access to reproductive information relevant to ACHD patients.ConclusionsThe absence of patient characteristics distinguishing those in ACHD care versus those still followed in paediatric care suggests that system, provider, and parent factors, rather than patient factors, may account for patients' perspectives on transfer to ACHD care.
Comparing Meta‐analysis and Individual Person Data Analysis Using Raw Data on Children's Understanding of Equivalence
Authors: Hornburg Caroline Byrd , Wang Lijuan , McNeil Nicole M. 
Published: March 2018

A prevailing theory of mathematical problem solving predicts that children will be less accurate solving a + b = c + __ problems versus a + b = __ + c. However, this has never been tested directly. Because of low base rates, information combined from multiple studies can help improve estimation accuracy and precision. This study compared meta‐analysis and individual person data (IPD) analysis using raw data from 14 studies (N = 1,414; ns = 30–232; Mage reported = 8;7). Substantive results challenge the prevailing theory. Methodological results demonstrate the advantages of using meta‐analysis and IPD over single‐study analysis. Moreover, IPD can be more powerful than meta‐regression for detecting between‐study moderation effects.
Worse Health‐Related Quality of Life at long‐term follow‐up in patients with Cushing's disease than patients with cortisol producing adenoma. Data from the ERCUSYN
Authors: Valassi Elena , Feelders Richard , Maiter Dominique , Chanson Philippe , Yaneva Maria , Reincke Martin , Krsek Michal , Tóth Miklós , Webb Susan M. , Santos Alicia , Paiva Isabel , Komerdus Irina , Droste Michael , Tabarin Antoine , Strasburger Christian J , Franz Holger , Trainer Peter J , Newell‐Price John , Wass John AH , Papakokkinou Eleni , Ragnarsson Oskar ,   the ERCUSYN Study Group
Published: March 2018

SummaryObjectiveHypercortisolism in Cushing's syndrome (CS) is associated with impaired health‐related quality of life (HRQoL), which may persist despite remission. We used the data entered into the European Registry on Cushing's syndrome (ERCUSYN) to evaluate if patients with CS of pituitary origin (PIT‐CS) have worse HRQoL, both before and after treatment than patients with adrenal causes (ADR‐CS).MethodsData from 595 patients (492 women; 83%) who completed the CushingQoL and/or EQ‐5D questionnaires at baseline and/or following treatment were analysed.ResultsAt baseline, HRQoL did not differ between PIT‐CS (n = 293) and ADR‐CS (n = 120) on both EuroQoL and CushingQoL. Total CushingQoL score in PIT‐CS and ADR‐CS was 41 ± 18 and 44 ± 20, respectively (P = .7). At long‐time follow‐up (>1 year after treatment) total CushingQoL score was however lower in PIT‐CS than ADR‐CS (56 ± 20 vs 62 ± 23; P = .045). In a regression analysis, after adjustment for baseline age, gender, remission status, duration of active CS, glucocorticoid dependency and follow‐up time, no association was observed between aetiology and HRQoL. Remission was associated with better total CushingQoL score (P < .001), and older age at diagnosis with worse total score (P = .01). Depression at diagnosis was associated with worse total CushingQoL score at the last follow‐up (P < .001).ConclusionPIT‐CS patients had poorer HRQoL than ADR‐CS at long‐term follow‐up, despite similar baseline scoring. After adjusting for remission status, no interaetiology differences in HRQoL scoring were found. Age and presence of depression at diagnosis of CS may be potential predictors of worse HRQoL regardless of CS aetiology.
Clinical and esthetic outcome with immediate insertion and provisionalization with or without connective tissue grafting in presence of mucogingival recessions: A retrospective analysis with follow‐up between 1 and 8 years
Authors: Noelken Robert , Moergel Maximilian , Pausch Tobias , Kunkel Martin , Wagner Wilfried 
Published: March 2018

AbstractBackgroundRecessions following immediate implant insertion are frequently reported in the literature. Data regarding implant installation in presence of mucogingival recessions are rare.PurposeThis study observes soft tissue level changes following immediate implant insertion and provisionalization of implants with or without connective tissue grafts in the anterior maxilla in patients with initial mucogingival recession within a follow‐up period between one and eight years.Materials and MethodsTwenty‐six patients with marginal gingival recessions, which were designated for extraction and immediate implant insertion in the anterior zone of the maxilla (13‐23), were included. Out of a larger group of immediate implants only single tooth replacements with 1 to 3 mm recession and a pre‐ and post‐op CB‐CT were selected. Facial bone deficiencies were grafted flaplessly with autologous bone in all sites. In a group of 13 patients the recessions (mean 2.3 ± 0.7 mm, range 1.0‐3.0 mm) were grafted additionally by connective tissue (ABG + CTG), in the remaining 13 patients no soft tissue grafting (mean recession 1.8 ± 0.6 mm, range 1.0‐3.0 mm) was performed (ABG). The marginal hard and soft tissue level, the width of the keratinized mucosa, the PES, and implant success were evaluated.ResultsAfter a mean follow‐up period of 45 months the recessions were significantly reduced in the ABG group from 1.8 to 0.9 mm. The improvement was even more pronounced in the ABG + CTG group (from 2.3 to 0.5 mm). The PES improved significantly in both groups. At final examination all implants were still in function. Within the observational period, in 5 of 13 implants a marginal bone loss of more than 1 mm was noticed in the ABG, but in none of the ABG + CTG group.ConclusionsThese clinical results provide evidence that immediate implant placement might improve the facial soft tissue level. This was more evident in cases with a greater recession and an additional treatment with connective tissue grafts.
Peri‐implant parameters, tumor necrosis factor‐alpha, and interleukin‐1 beta levels in vaping individuals
Authors: Al‐Aali Khulud A. , Alrabiah Mohammed , ArRejaie Aws S. , Abduljabbar Tariq , Vohra Fahim , Akram Zohaib 
Published: March 2018

AbstractBackgroundTo the author's knowledge, there has been no study that has assessed clinical, radiographic, and immunological peri‐implant parameters among individuals vaping e‐cigarette (e‐cig).PurposeThis pilot study aimed to compare clinical and radiographic peri‐implant parameters and levels of tumor necrosis factor alpha (TNF‐α) and interleukin (IL)‐1β levels among individuals vaping e‐cigs and never smoker (NS).Materials and MethodsForty‐seven individuals vaping e‐cigs (group‐1) and 45 NS (group‐2) were included. Demographic and implant‐related data were collected using a structured baseline questionnaire. Peri‐implant plaque index (PI), bleeding on probing (BOP), and probing depth (PD) were recorded and peri‐implant bone loss (PIBL) were assessed using standardized digital radiographs. Enzyme‐linked immunosorbent assay was used to assess the levels of TNF‐α and IL‐1β in peri‐implant sulcular fluid.ResultsBleeding on probing showed statistically significantly higher values in group‐2 patients as compared to group‐1 patients (P < .01). Probing depth ≥ 4 mm and PIBL was statistically significantly higher in group‐1 patients as compared to group‐2 patients (P < .05). Mean concentrations of TNF‐α (P < .001) and IL‐1β (P < .01) were statistically significantly increased in individuals in group 1 as compared with group 2. A significant positive correlations were found between TNF‐α levels and BOP (P = .024) and PIBL (P = .016); and significant positive correlation was found between IL‐1β and PIBL (P = .018) in group 1, respectively.ConclusionsClinical and radiographic peri‐implant parameters are compromised among vaping individuals. Increased levels of proinflammatory cytokines in peri‐implant sulcular fluid may suggest greater local inflammatory response in vaping individuals for peri‐implant inflammation.
Guided maxillary sinus floor elevation using deproteinized bovine bone versus graftless Schneiderian membrane elevation with simultaneous implant placement: Randomized clinical trial
Authors: Fouad Waleed , Osman Ahmed , Atef Mohammed , Hakam Maha 
Published: March 2018

AbstractObjectiveThe aim of this study is to evaluate the analytical difference between the use of xenograft (control group) and graftless tenting (test group) technique after sinus lift procedure with simultaneous implant placement.Materials and methodsSeventeen patients and 20 sinuses where operated for sinus lift procedures using lateral window approach with simultaneous implant placement. Deproteinized bovine bone (Xenograft) was used as a filling material in control group while nongrafted sinus lifting was performed in the test group. Multislice CT was obtained preoperatively and CBCT were obtained immediately postoperative and 6 months after operation. Osstell readings were taken at the time of implant placement and implant exposure (6 months)ResultsMean bone height gain in the xenograft group was 8.59 ± 0.74 while that of the tenting group was 4.85 ± 0.5 and it was statistically significant (P < .05). Mean bone density values in the xenograft group was 375.59 ± 49.38 while that of the tenting group was 269.08 ± 16.27 and it was statistically significant (P < .05). Mean ISQ values for the xenograft group was 78.3 ± 5.08 while that of the tenting group was 74 ± 3.19 and it was statistically significant (P < .05).ConclusionsWithin the limitation of this study, sinus lift procedures with simultaneous implant placement using xenograft as a filling material or graftless technique are considered reliable procedures, however, the use of xenograft provide better results in all aspects regarding (bone height gain, bone density, and implant stability).
Long‐term outcome of surgical treatment of peri‐implantitis. A 2‐11‐year retrospective study
Authors: Berglundh Tord , Wennström Jan L. , Lindhe Jan 
Published: March 2018

AbstractObjectiveTo assess long‐term clinical and radiological outcomes of surgical treatment of peri‐implantitis.Material and methodsFiles and radiographs from 50 patients who had received surgical treatment for peri‐implantitis were analyzed. Data on clinical characteristics prior to surgical therapy and at latest follow‐up were obtained. In each radiograph, the marginal bone level was assessed at the mesial and distal aspects of the affected implants. The treatment included oral hygiene instruction, professional supra‐mucosal instrumentation, and surgical therapy aiming at pocket elimination. Following flap elevation and removal of inflamed tissue, the affected implant was cleaned using gauze soaked in saline. Calculus was removed. When indicated, osseous re‐contouring was carried out to facilitate pocket elimination. Flaps were adjusted, sutured, and compressed to the crestal bone. Supportive therapy including oral hygiene control was provided with 4‐month intervals.ResultsTreatment was effective in resolving the inflammatory condition as documented by marked reduction in peri‐implant probing depth and bleeding on probing scores together with crestal bone level preservation. Treatment outcome was significantly better at implants with non‐modified surfaces than at implants with modified surfaces. The probability of an implant to exhibit no further bone loss or bone gain after treatment was high if the peri‐implant mucosa at the site presented with shallow pockets and the absence of bleeding on probing at follow‐up.ConclusionsThe results of the study revealed that (i) surgical treatment of peri‐implantitis was effective in the long‐term, (ii) outcome was better at implants with non‐modified than with modified surfaces, and (iii) preservation of crestal bone support was consistent with healthy peri‐implant tissue conditions.
Functional outcome and service engagement in major depressive disorder with psychotic features: comparisons with schizophrenia, schizoaffective disorder and bipolar disorder in a 6‐year follow‐up of the Cavan‐Monaghan First Episode Psychosis Study (CAMFEPS)
Authors: Kingston Tara , Scully Paul J. , Browne David J. , Baldwin Patrizia A. , Kinsella Anthony , O'Callaghan Eadbhard , Russell Vincent , Waddington John L. 
Published: March 2018

SummaryObjectiveWhile long‐term outcome following a first psychotic episode is well studied in schizophrenia (SZ), schizoaffective disorder (SA), and bipolar disorder (BD), major depressive disorder with psychotic features (MDDP) has received less investigation. This study compares MDDP with SZ, SA, and BD at 6‐year follow‐up.MethodsAt 6 years after a first psychotic episode, follow‐up data on psychopathology, functioning, quality of life, and service engagement were obtained for 27 cases of MDDP in comparison to 60 SZ, 27 SA, and 35 BD.ResultsPositive psychotic symptoms were less prominent in MDDP and BD than in SZ and SA. Negative symptoms, impaired functioning, and reduction in objectively determined quality of life were less prominent in MDDP and BD, intermediate in SA and most prominent in SZ. However, subjectively determined quality of life was indistinguishable across diagnoses. Service engagement was highest for MDDP, intermediate for SA and BD, and lowest for SZ.ConclusionsAt 6‐year follow‐up, these diagnoses are characterized by quantitative rather than qualitative differences in psychopathology, functionality, quality of life, and service engagement, with considerable overlap between them. These findings suggest that MDDP should join SZ, SA, and BD in a milieu of psychosis that transcends arbitrary boundaries.
Hearing aids in patients with vestibular schwannoma: Interest of the auditory brainstem responses
Authors: Reffet K. , Lescanne E. , Bobillier C. , Aussedat C. , Bakhos D. 
Published: March 2018

ObjectiveHearing loss subsequent to a unilateral vestibular schwannoma (VS) has an impact on the social life of non‐operated patients. We investigated the utility of auditory brainstem responses (ABRs) for predicting the results of auditory rehabilitation in such patients.DesignProspective study.SettingUniversity tertiary medical centre.ParticipantsWe collected the demographic, audiometric, ABR and imaging data of non‐operated patients with unilateral VS. A hearing aid trial was performed over 1 month. We assessed auditory performance following the auditory rehabilitation according to the ABR results. Patients with distinct waves (I, III and V) were included in the “distinct ABR” group and patients with no ABR were included in the “desynchronised ABR” group. Main outcome measures: Following the trial, audiometric performance and quality of life were evaluated with the Glasgow Benefit Inventory (GBI).Subjects and MethodWe collected the demographic, audiometric, ABR and imaging data of non‐operated patients with unilateral VS. A hearing aid trial was performed over 1 month. Following the trial, audiometric performance and quality of life were evaluated with the Glasgow Benefit Inventory (GBI). We assessed auditory performance following the auditory rehabilitation according to the ABR results. Patients with distinct waves (I, III and V) were included in the “distinct ABR” group and patients with no ABR were included in the “desynchronised ABR” group.ResultsIn total, 25 patients were included in this prospective study; 15 in the “distinct ABR” group and 10 in the “desynchronised ABR” group. The speech recognition threshold (SRT, P < .0001; W = −120) and speech discrimination score (P = .0005; W = 78) were significantly improved in the aided vs unaided conditions. These improvements were not observed in the “desynchronised ABR” group for the SRT (P = .48; W = −10) and word recognition score (P = .06; W = 15). Ninety‐three per cent of the patients in the “distinct ABR” group kept significantly (P = .04) the hearing aids following the trial compared to 20% in the “desynchronised ABR” group.ConclusionsAuditory brainstem responses can help to predict the auditory performance following auditory rehabilitation in unilateral non‐operated VS patients.