bluuebunny/crossref_metadata_2025_split huggingface dataset:
Coping, stress, and negative childhood experiences: The link to psychopathology, self‐harm, and suicidal behavior
Authors: McLafferty Margaret , Armour Cherie , Bunting Brendan , Ennis Edel , Lapsley Coral , Murray Elaine , O'Neill Siobhan 
Published: June 2019

AbstractEarly life experiences, such as childhood adversities or poor parenting practices, can impact on the ability to cope with stressors across the lifespan. Furthermore, poor coping skills can lead to the development of mental illnesses, self‐harm, and suicidal behavior. This study aimed to examine demographic differences in stress levels and to determine if those who had endured negative childhood experiences would be more likely to develop psychological problems and display suicidal behavior when current stress levels were accounted for. The study also explored the link between coping and mental health problems. Finally, it aimed to predict risk and protective factors related to good coping skills. The study utilized data obtained from the Ulster University Student Wellbeing Study, conducted across four university campuses in Northern Ireland in 2015 (n = 716) as part of the World Health Organization World Mental Health (WMH) International College Student Initiative. Mental health problems and early childhood experiences were examined using questions adapted from the WMH Composite International Diagnostic Interview, with self‐harm and suicidal behavior measured using the Self‐Injurious Thoughts and Behaviors Interview (SITBI). Females, non‐heterosexuals, and older students experienced more current stress. When current stress levels were high, childhood adversities and parental overcontrol and overindulgence were related to higher rates of mental health problems, self‐harm, and suicidal behavior. Poor coping skills were associated with negative mental health outcomes. Social support and good emotion‐regulation strategies were related to effective coping, while parental overcontrol and overindulgence, female gender, and younger age were related to poorer coping. The study highlights the importance of developing good coping skills to deal with life stressors, thereby minimizing the risk of psychological problems and suicidal behavior. The findings provide support for initiatives to help parents improve their parenting skills and other programs to help young people cope with stress, and to develop social networks and adaptive emotion‐regulation strategies.
Production of antimicrobial silver nanoparticles modified by alkanethiol self‐assembled monolayers by direct current atmospheric pressure glow discharge generated in contact with a flowing liquid anode
Authors: Dzimitrowicz Anna , Krychowiak‐Masnicka Marta , Pohl Pawel , Krolicka Aleksandra , Cyganowski Piotr , Jermakowicz‐Bartkowiak Dorota , Jamroz Piotr 
Published: June 2019

AbstractDirect current atmospheric pressure glow discharge (dc‐APGD) generated in contact with a flowing liquid anode (FLA) is used for continuous synthesis of size‐defined silver nanoparticles (AgNPs) modified by a (11‐mercaptoundecyl)‐N,N,N‐trimethylammonium chloride (TMA) alkanethiol self‐assembled monolayer. The impact of the operating parameters (concentration of Ag(I) ions, solution flow rate, discharge current) on the size of TMA‐AgNPs is examined. Design of experiments along with response surface methodology reveals that it is possible to obtain size‐defined TMA‐AgNPs, the smallest being 1.21 ± 0.80 nm. Furthermore, the reactive species involved in formation of TMA‐AgNPs are identified using optical emission spectrometry. TMA‐AgNPs are characterized by several other experimental techniques, which confirm production of approximately spherical, well‐dispersed TMA‐AgNPs. Additionally, attenuated total reflection Fourier transform infrared spectroscopy and UV/Vis absorption spectrophotometry confirmed that the surface of Ag nanostructures is covered by TMA. TMA‐AgNPs display antimicrobial activity toward multiple human pathogens (Escherichia coli, Staphylococcus aureus, and Candida albicans) with minimal bactericidal concentrations or minimal fungicidal concentrations of 3.90 ± 0.15, 7.79 ± 0.30, and 3.90 ± 0.15 mg/L, respectively.
Strengths and limitations of Bacillus thuringiensis galleriae for managing Japanese beetle (Popillia japonica) adults and grubs with caveats for cross‐order activity to monarch butterfly (Danaus plexippus) larvae
Authors: Redmond Carl T , Wallis Lindsey , Geis Matthew , Williamson R Chris , Potter Daniel A 
Published: June 2019

AbstractBACKGROUNDTarget‐selective biopesticides are needed to facilitate integrated pest and pollinator management in urban landscapes and gardens. Bacillus thuringiensis galleriae, strain SDS‐502 (Btg), recently registered in the USA and Canada, produces Cry8Da protein active against scarab beetles. We evaluated Btg formulations for managing the Japanese beetle [Popillia japonica Newman (JB)], a polyphagous invasive pest, including residual spray effectiveness for reducing adult feeding on Rosa and Tilia spp., and granular formulations for early‐ or late‐curative control of root‐feeding grubs in turfgrass. We also tested for cross‐order activity to monarch butterfly (Danaus plexippus L.) larvae and other non‐target insects.RESULTSField‐weathered Btg residues reduced JB feeding on foliage for 3–14 days. Most beetles were still flight‐capable after 24 h confinement with Btg‐treated leaves. Granular Btg failed to control early‐ or late‐instar JB grubs in soils under several turfgrass species at multiple field sites. In three trials, feeding on Btg‐sprayed milkweed resulted in 97–100% mortality of early instar monarchs, with symptoms of B. thuringiensis pathogenesis. Fall armyworms (Spodoptera frugiperda (J.E. Smith)) fed Btg‐treated grass had reduced body mass, but there were no adverse effects on lady beetle larvae preying on Btg‐sprayed aphids or on the aphids themselves.CONCLUSIONThis study supports efficacy of Btg strain SDS‐502 for reducing defoliation by adult JB in urban landscape settings. Granular formulations, however, failed to control JB grubs in turfgrass soils. Btg should not be used in gardens with larval host plants of the monarch butterfly or other non‐pest Lepidoptera, especially species of conservation concern. © 2019 Society of Chemical Industry
Stable Intracerebral Transplantation of Neural Stem Cells for the Treatment of Paralysis Due to Ischemic Stroke
Authors: Zhang Guangzhu , Li Ying , Reuss James L. , Liu Nan , Wu Cuiying , Li Jingpo , Xu Shuangshuang , Wang Feng , Hazel Thomas G. , Cunningham Miles , Zhang Hongtian , Dai Yiwu , Hong Peng , Zhang Ping , He Jianghong , Feng Huiru , Lu Xiangdong , Ulmer John L. , Johe Karl K. , Xu Ruxiang 
Published: June 2019

Abstract
NSI-566 is a stable, primary adherent neural stem cell line derived from a single human fetal spinal cord and expanded epigenetically with no genetic modification. This cell line is being tested in clinical trials in the U.S. for treatment of amyotrophic lateral sclerosis and spinal cord injury. In a single-site, phase I study, we evaluated the feasibility and safety of NSI-566 transplantation for the treatment of hemiparesis due to chronic motor stroke and determined the maximum tolerated dose for future trials. Three cohorts (n = 3 per cohort) were transplanted with one-time intracerebral injections of 1.2 × 107, 2.4 × 107, or 7.2 × 107 cells. Immunosuppression therapy with tacrolimus was maintained for 28 days. All subjects had sustained chronic motor strokes, verified by magnetic resonance imaging (MRI), initiated between 5 and 24 months prior to surgery with modified Rankin Scores [MRSs] of 2, 3, or 4 and Fugl-Meyer Motor Scores of 55 or less. At the 12-month visit, the mean Fugl-Meyer Motor Score (FMMS, total score of 100) for the nine participants showed 16 points of improvement (p = .0078), the mean MRS showed 0.8 points of improvement (p = .031), and the mean National Institutes of Health Stroke Scale showed 3.1 points of improvement (p = .020). For six participants who were followed up for 24 months, these mean changes remained stable. The treatment was well tolerated at all doses. Longitudinal MRI studies showed evidence indicating cavity-filling by new neural tissue formation in all nine patients. Although this was a small, one-arm study of feasibility, the results are encouraging to warrant further studies. Stem Cells Translational Medicine 2019;8:999–1007
Carbon Dots, Unconventional Preparation Strategies, and Applications Beyond Photoluminescence
Authors: Tian Xue‐Tao , Yin Xue‐Bo 
Published: June 2019

AbstractCarbon dots (C‐dots) are generally separated into graphene quantum dots (GQDs) and carbon nanodots (CNDs) based on their respective top‐down and bottom‐up preparation processes. However, GQDs can be prepared by carbonization of small‐molecule precursors as revealed with unconventional preparation strategies. Thus, it is their structures rather than their precursors and preparation strategy that govern whether C‐dots are GQDs or CNDs. Here, the composites, structure, and electronic properties of C‐dots are discussed. C‐dots generally consist of a graphite‐like core and amorphous oxygen‐containing shell. When graphite becomes C‐dots, its conduction and valence bands are separated, and the quantum confinement effect appears. Combined with the light‐harvesting ability inherited from graphite, electrons in the core of C‐dots are transferred from conduction to valence bands, leading to electron–hole pair formation upon light excitation. The photoexcitation activities, such as photovoltaic conversion, photocatalysis, and photodynamic therapy, are influenced by the electronic properties of the core. Different to the semiconductor properties of core, the C‐dot shell is electrochemically active, leading to electrochemiluminescence (ECL). The oxygen‐containing groups in shell can conjugate to functional species for use in imaging and therapy. The applications of C‐dots beyond photoluminescence, including ECL, solar photovoltaics, photocatalysis, and theranostics, are reviewed.
Treatment of petrochemical wastewater and produced water from oil and gas
Authors: Wei Xinchao , Zhang Shicheng , Han Yuexin , Wolfe Frederick Andrew 
Published: June 2019

AbstractWastewater in petrochemical processes and produced water from oil and gas production remain a challenge for the industry to minimize their impact on the environment. Recent research and development of treatment technologies for petrochemical wastewater and produced water from oil and gas industries published in 2018 were summarized in this annual review. Great efforts and progresses were made in various treatment options, including membrane processes, advanced oxidation, biological systems, adsorption, coagulation, and combined processes.Practitioner points

Treatment technologies for petrochemical wastewater are reviewed.

Research development in produced water from oil and gas industries is summarized.

Reviewed technologies include traditional, advanced, and innovative processes.
A comparative analysis of digital forensic readiness models using CFRaaS as a baseline
Authors: Kebande Victor Rigworo , Venter Hein S. 
Published: June 2019

AbstractDigital forensic readiness (DFR) aims at maximizing the potential of conducting a digital forensic investigation while minimizing the cost of conducting postevent processes when a potential security incident is detected. Conducting digital forensic investigation (DFI) process and changing the functionality of software architectures and/or infrastructures while conducting these processes is a costly exercise; however, the availability of DFR processes can shorten and save the cost of these processes. A comparative analysis of the DFR process models is given that makes a strict comparison with the cloud forensic readiness as a service (CFRaaS) model. The main reason the CFRaaS model has been used as a basis for comparison is because it has been constructed by modifying the functionality of initially considered malicious botnets to allow the removal of potential digital evidence from the cloud without changing the architecture or the infrastructure of the cloud while conducting digital forensic processes. It is worth to note that the CFRaaS processes have been carefully developed based on the guidelines of ISO/IEC 27043:2015 international standards for information technology, security techniques, incident investigation principles and processes. Nevertheless, additional postevent response processes have also been incorporated in the CFRaaS like the reconstruction of the events and the Incident Response Procedures processes. The outcome of the comparison has shown promising results worth exploring.This article is categorized under:

Digital and Multimedia Science > Cloud Forensics
Digital and Multimedia Science > Cyber Threat Intelligence
MoDigital and Multimedia Science > Forensic Visualization
Use of magnetic fields and nanoparticles to trigger drug release and improve tumor targeting
Authors: Liu Jessica F. , Jang Bian , Issadore David , Tsourkas Andrew 
Published: June 2019

AbstractDrug delivery strategies aim to maximize a drug's therapeutic index by increasing the concentration of drug at target sites while minimizing delivery to off‐target tissues. Because biological tissues are minimally responsive to magnetic fields, there has been a great deal of interest in using magnetic nanoparticles in combination with applied magnetic fields to selectively control the accumulation and release of drug in target tissues while minimizing the impact on surrounding tissue. In particular, spatially variant magnetic fields have been used to encourage accumulation of drug‐loaded magnetic nanoparticles at target sites, while time‐variant magnetic fields have been used to induce drug release from thermally sensitive nanocarriers. In this review, we discuss nanoparticle formulations and approaches that have been developed for magnetic targeting and/or magnetically induced drug release, as well as ongoing challenges in using magnetism for therapeutic applications.This article is categorized under:

Diagnostic Tools > in vivo Nanodiagnostics and Imaging
Therapeutic Approaches and Drug Discovery > Emerging Technologies
Therapeutic Approaches and Drug Discovery > Nanomedicine for Oncologic Disease
Master integrals for the NNLO virtual corrections to $$ q\overline{q}\to t\overline{t} $$ scattering in QCD: the non-planar graphs
Authors: Di Vita Stefano , Gehrmann Thomas , Laporta Stefano , Mastrolia Pierpaolo , Primo Amedeo , Schubert Ulrich 
Published: June 2019

AbstractWe complete the analytic evaluation of the master integrals for the two-loop non-planar box diagrams contributing to the top-pair production in the quark-initiated channel, at next-to-next-to-leading order in QCD. The integrals are determined from their differential equations, which are cast into a canonical form using the Magnus exponential. The analytic expressions of the Laurent series coefficients of the integrals are expressed as combinations of generalized polylogarithms, which we validate with several numerical checks. We discuss the analytic continuation of the planar and the non-planar master integrals, which contribute toq q→ttin QCD, as well as to the companion QED scattering processesee→ μμ andeμ →eμ.
Proposal of a Useful Surrogate Endpoint of the Overall Survival in Patients Undergoing Pulmonary Metastasectomy: The Time to Local Therapy Failure
Authors: Kanzaki Ryu , Kanou Takashi , Ose Naoko , Funaki Soichiro , Minami Masato , Tajima Testuya , Fujii Makoto , Ohno Yuko , Shintani Yasushi 
Published: June 2019

AbstractBackgroundA recent study demonstrated remarkable discrepancy between the relapse‐free survival (RFS) and overall survival (OS) after pulmonary metastasectomy (PM) in the current era. As the RFS may not be a suitable parameter after PM, a more suitable parameter is needed for PM as a surrogate marker for OS.MethodsA total of 134 consecutive patients who underwent PM were retrospectively analyzed. In the present study, we introduced a new endpoint, time to local treatment failure (TLTF). This endpoint was defined as the time interval between the first PM and the first untreatable recurrence by local treatment with curative intent or death due to any cause. We analyzed the correlation between the RFS and OS and between the TLTF and OS to validate whether or not the TLTF is a better parameter than the RFS after PM.ResultsThus far, 78 patients have experienced relapse. Of these, 37 patients (47%) underwent local therapy with curative intent, 29 of whom are alive without local treatment failure. The 5‐year OS, RFS and TLTF were 70.9%, 36.5%, and 57.6%, respectively. The concordance proportions for the RFS and OS and for the TLTF and OS were 0.634 and 0.851 for all patients, respectively. The Spearman's rank correlation coefficient for the RFS and OS was 0.639, while that for the TLTF and OS was 0.875.ConclusionsThe TLTF may be a good surrogate parameter for the OS after PM in the current era.
Anticancer activity of a novel methylated analogue of L-mimosine against an in vitro model of human malignant melanoma
Authors: Kyriakou Sotiris , Mitsiogianni Melina , Mantso Theodora , Cheung William , Todryk Stephen , Veuger Stephany , Pappa Aglaia , Tetard David , Panayiotidis Mihalis I. 
Published: June 2019

SummaryThe anticancer activity of a series of novel synthesized, hydroxypyridone-based metal chelators (analogues of L-mimosine) was evaluated in an in vitro model of melanoma consisting of malignant melanoma (A375), non-melanoma epidermoid carcinoma (A431) and immortalized non-malignant keratinocyte (HaCaT) cells. More specifically, we have demonstrated that the L-enantiomer of a methylated analogue of L-mimosine (compound 22) can exert a potent anticancer effect in A375 cells when compared to either A431 or HaCaT cells. Moreover, we have demonstrated that this analogue has the ability to i) promote increased generation of reactive oxygen species (ROS), ii) activate both intrinsic and extrinsic apoptosis and iii) induce perturbations in cell cycle growth arrest. Our data highlights the potential of compound 22 to act as a promising therapeutic agent against an in vitro model of human malignant melanoma.
How to diagnose and treat benign headaches
Authors: Rowe Brian H. , Villa-Roel Cristina , Krebs Lynette D. 
Published: June 2019

A 19-year-old female, university student with a long-standing history of migraine headaches presented to the emergency department (ED) with a 36-hour history of gradual onset of left-sided headache, preceded by visual aura. She stated that her headache was worse than usual and now associated with nausea, vomiting, and photophobia, despite use of oral ibuprofen. On examination, she was afebrile, her SaO2 = 98% on room air, her pulse was 110 beats/minute, and she was breathing 20 breaths/minute. She received a Canadian Triage and Acuity Scale score of 2 due to her pain score of 8/10 on a Visual Analogue Scale (VAS). Her neurological examination was normal and her neck was supple with full range of motion. She was a non-smoker, infrequent cannabis user, and her last menstrual period was normal.
Non-Invasive CPAP Ventilation in Acute Carbon Monoxide Poisoning
Authors: Idil Hasan , Unek Orkun 
Published: June 2019

AbstractOxygen is the main treatment of carbon monoxide (CO) poisoning. In two simultaneous cases, the efficacy of conventional and continuous positive airway pressure (CPAP)-administered oxygen therapy was compared. A 63-year-old man and his 58-year-old wife were brought to the emergency department with complaints of dizziness, headache, and nausea. The man had a history of congestive heart failure and additionally had shortness of breath. Initial carboxyhemoglobin (COHb) values were 26% in the male patient and 24% in his wife. For the female patient, oxygen therapy was performed with a reservoir balloon mask; a CPAP device was used for the male patient. The COHb levels decreased below five percent after approximately two hours in the male patient and at the end of five hours in his wife. In follow-up, symptomatic relief was achieved in both patients and no additional complications were observed. According to our experience, CPAP ventilation can be a new and effective method for oxygen therapy in CO poisoning.
Psychotherapists’ reports of technique use when treating anxiety disorders: factors associated with specific technique use
Authors: Parker Zachary J. , Waller Glenn 
Published: June 2019

AbstractCognitive behavioural therapy (CBT) is the most efficacious and effective psychological intervention for treating anxiety disorders. Behavioural techniques, in particular exposure-based techniques, are fundamental to positive outcomes. However, research suggests that these techniques are either not used or are under-used when treating anxiety disorders. This study assesses therapists’ reported use of CBT techniques in the treatment of anxiety disorders, and explores which therapist variables influence technique use. A total of 173 CBT therapists completed measures on their demographics, routine therapy practices in treating anxiety disorders, and internal states (e.g. self-esteem). These data were analysed to see how often therapists employed particular techniques and the correlates of the use of those techniques. Behavioural techniques (e.g. exposure) were the least utilized set of core CBT skills, being used less often than non-CBT techniques. The under-utilization of these key techniques was associated with greater levels of increased inhibitory anxiety amongst therapists. Supervision and therapists’ self-esteem were both positively associated with the use of non-CBT techniques. While this study established what CBT therapists purport to use in routine practice with anxious populations, further research is needed to assess the association between adherence (or lack thereof) and client outcomes, and the factors that drive non-adherence.Key learning aimsAs a result of reading this paper, the reader should:
(1)Learn about what psychotherapists report as occurring in routine care for individuals with anxiety and related disorders.(2)Know the potential therapist traits that influence the use of CBT techniques.(3)Gain knowledge to help explain to clients why previous therapy may not have been effective.(4)Develop a richer understanding of what factors may influence their own therapeutic practice.