bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessing the Effects of Palm Oil Consumption on Life Expectancy, Metabolic Markers, and Oxidative Stress in Drosophila melanogaster
Authors: da Silva Gustavo Felipe , Rodrigues Nathane Rosa , Boligon Aline Augusti , Ávila Eduardo , da Rosa Silva Luan , Franco Jeferson Luis , Posser Thaís 
Published: November 2024

ABSTRACTPalm oil is the world's second most consumed vegetable oil, sourced from the tropical palm tree Elaeis guineensis. Its consumption has been associated with a higher incidence of cardiovascular disease, largely due to its elevated palmitic acid content, however those studies are contradictory and inconclusive. Wishing to contribute to this issue, the present study aims to investigate the molecular and toxicological effects of this oil and the involvement of oxidative stress, given its role in metabolic dysfunctions using Drosophila melanogaster. This study examines survival rates, and locomotor performance, oxidative status by analysis of lipid peroxidation, ROS formation, thiol levels and antioxidant enzyme activity, and metabolic parameters such as cholesterol and triglycerides, glucose, trehalose and glycogen levels. Exposure to palm oil concentrations of 10% and 30% resulted in a shortened lifespan, reduced locomotor performance, and increased lipid peroxidation, with lower thiol levels and antioxidant enzyme modulation. Cholesterol levels was increased whereas energetic fuels as glucose and glycogen and trehalose were decreased mainly after 10 days of exposure. These findings underscore the detrimental effects of high‐fat diets containing palm oil on lifespan, antioxidant defenses, and metabolism in Drosophila melanogaster. This data highlights the potential risk associated with the habitual consumption of palm oil in the daily diet by population, particularly concerning cardiovascular health and metabolic function.
Proton‐conducting γ‐sulfopropyl Acrylate Tethered Halato‐Telechelic PVDF Membranes for Vanadium Redox Flow Batteries
Authors: Sharma Jeet , Améduri Bruno , Kulshrestha Vaibhav 
Published: November 2024

AbstractAdvanced fluorinated proton‐conducting membrane are dominating functional macromolecules due to their high performance in electrochemical energy devices. However, the co‐ion leakage and low power densities still proposes a challenge. Herein, a novel functionally tailored polyvinylidene fluoride‐co‐(γ)‐sulfopropyl acrylate (PVDF‐g‐SA) based proton‐conducting membrane is prepared for vanadium redox flow batteries (VRFBs). The approach introduces a facile guideline to design halato‐telechelic −SO3H architectures by tethering γ‐sulfopropyl acrylate onto dehydrofluorinated PVDF. The optimized PVDF‐g‐SA‐15 exhibits proton conductivity (κmH+) of 17 mS cm−1 (akin Nafion: ~19 mS cm−1) and retained 87 % and >95 % of its properties in Fenton's reagent and 3 M H2SO4, respectively. In VRFB device, the PVDF‐g‐SA‐15 shows ∼98 % capacity utilization outperforming Nafion‐117 (∼85 %). Moreover, bearing dense ionic orientation (viz AFM phases), the potential drop rate is ~2× lower for PVDF‐g‐SA‐15 (1.4×10−3 V min−1) than that of Nafion‐117 (2.6×10−3 V min−1). Operational endurance is evaluated fit for 150 mA cm−2 showing maximum coulombic, energy and voltage efficiencies of >98 %, ∼78 %, ∼80 %, respectively. Further investigation for ~200 cycles infer excellent durability with ∼95 % property retention. Additionally, the PVDF‐g‐SA‐15 can deliver ~20 % higher power density than Nafion‐117 does. Thus, the revealed alternate membrane holds promising utility in VRFB applications.
Quantifying the Site Heterogeneities of Non‐Uniform Catalysts Using QuantEXAFS
Authors: Rana Rachita , Hong Jiyun , Hoffman Adam S. , Werghi Baraa , Bare Simon R. , Kulkarni Ambarish R. 
Published: November 2024

AbstractWe present the Multi‐site (MS) QuantEXAFS approach, designed to model the EXAFS data from samples containing an element in different local bonding geometries. Building upon our QuantEXAFS method, which maps experimental extended X‐ray absorption fine structures (EXAFS) data to DFT‐optimized structures, MS‐QuantEXAFS introduces the key capability to probe fractional contributions of multiple sites that may be present in an experimental sample. Specifically, we demonstrate effectiveness of this technique by investigating mixed samples containing known fractions of site‐isolated subsurface Pt/MgO with Pt nanoparticles uniformly supported on MgO. The ‘site‐fractions’ obtained through MS‐QuantEXAFS closely match (i. e., ±6%) the known fractions of the physically mixed samples. This approach has been generalized to other oxides, and thus represents an important advance in quantifying the speciation of non‐uniform catalyst samples.
Engineering and Evaluating Vascularized Organotypic Spheroids On‐Chip
Authors: Tronolone James J. , Mohamed Nadin , Chaftari Christopher P. , Sun Yuxiang , Mathur Tanmay , Jain Abhishek 
Published: November 2024

AbstractOrganotypic spheroids are evolving as a mainstream in vitro modeling platform, but it is crucial to integrate vascular tissue and perfusion for maintaining their longevity, stability, and physiological relevance. Current vascularization methods remain underdeveloped, and several protocols are poorly reproducible and are limited to use by a few select groups who have designed these methods. To achieve standardization, we offer a step‐by‐step guide to vascularize organotypic spheroids in case studies of pancreatic islets and cancer spheroids. Our systematic approach spans microfluidic chip design, spheroid fabrication, and vascularization techniques (vasculogenesis and angiogenesis) while describing critical tissue engineering methods. We also include additional insights and operating guidelines within our protocols that characterize and quantitate these models with molecular assays as well as our integrated computational algorithms of mass transport through formed capillary vessels. These protocols contribute to establishing reproducibility, standardization, and enhanced adoption by other contemporary organ‐chip researchers, who want to engineer vascularized organoid‐based microphysiological platforms. © 2024 Wiley Periodicals LLC.Basic Protocol 1: Design and fabrication of microfluidic chips for vascularized spheroidsBasic Protocol 2: Organotypic spheroid fabricationBasic Protocol 3: Vascularized spheroids on‐chipBasic Protocol 4: Functionality assaysSupport Protocol 1: Cell CultureSupport Protocol 2: Immunocytochemistry
To what extent is the banking sector devoted to sustainability? A bibliometric and content analysis
Authors: Santiago Moises Flavia , Carvalho Marly Monteiro de 
Published: November 2024

AbstractThis research explores the diverse scenario of sustainability in the banking sector, aiming to comprehensively map the existing literature on the subject. It uses a comprehensive literature review methodology, applying bibliometric and content analysis techniques. Based on an analysis of 142 papers, the study traces the trajectory of sustainability in the banking sector, identifying key challenges and unresolved issues. The study not only offers insights into the interplay of sustainable practices but also sheds light on the internal struggles within the banking sector to integrate environmental, social, and governance practices into daily operations. The findings reveal that the main topics related to banking sustainability are sustainability reporting, banking performance, and customer loyalty. Additionally, the research examines the definitions of essential constructs, such as sustainable banking and finance, green banking and finance, exploring overlaps and distinctive characteristics. The findings provide valuable contributions to research by pinpointing critical literature gaps and offering practical insights into a broader sustainability agenda, including its primary challenges.
Design, Synthesis, and Biological Activities Evaluation of Type I FLT3 Inhibitors for the Treatment of Acute Myeloid Leukemia
Authors: Yang Jin , Zhang Yan , Li Yue‐Chu , Wang Qing‐Xin , Zhang Meng‐Yuan , Xu Yu‐Jing , Wang Jing‐Jing , Liang Xiao‐Ting , Jing Xiao‐Long , Zhou Shuang‐Shuang , Li Qing‐Qing , Wang Zi‐Xuan , Zhou Yun , Qiao Nuo , Wei Tian‐Hua , Ding Ning , Xue Xin , Yu Yan‐Cheng , Wang Xiao‐Long , Sun Shan‐Liang , Dai Wei‐Chen , Li Nian‐Guang , Shi Zhi‐Hao 
Published: November 2024

ABSTRACTThe abnormal overexpression of FLT3 kinase is intimately associated with pathogenesis of acute myeloid leukemia (AML), positioning FLT3 inhibitors as pivotal therapeutic agents. Despite the availability of three FDA‐approved FLT3 inhibitors, their clinical utility is hampered by resistance stemming from tyrosine kinase domain (TKD) mutations. Through an integrative analysis of case studies, we identified a potential advantage of type I FLT3 inhibitors in overcoming TKD mutation‐induced resistance. Structure–activity relationships (SAR) analysis indicated that FW‐1 exhibited over 50% inhibition against FLT3 at a concentration of 1 μM and demonstrated potent activity against AML cell lines MV4‐11 (IC50 = 2.68 μM) and MOLM‐13 (IC50 = 1.03 μM). In our cellular mechanistic studies, FW‐1 also effectively induced apoptosis by arresting cell cycle progression in the G0/G1 phase. This study introduces FW‐1 as a promising lead for type I FLT3 inhibitor, warranting further optimization.
P−F Bond Activation of Organophosphates by [(iPrPNHP)Mn(CO)2]+
Authors: Prejanò Mario , Toscano Marirosa , Marino Tiziana 
Published: November 2024

AbstractOrganophosphate compounds (OPC) are chemical species with a broad range of applications from agricultural to medicinal chemistry, which however rose sadly to the fore for their use as chemical weapons worldwide. Several efforts are therefore carried out to contrast their toxic effects or to repurpose OPC for chemical synthesis. In this regard, metal‐containing systems, like metal‐organic frameworks or complexes, represent a valid solution for the treatments of OPC in a number of fields. Our work has been inspired by the recent findings concerning the reactivity of (iPrPNHP)Mn(CO)2(OH) (1) complex with P−F bond containing organophosphate compounds. We, in particular, have investigated three different OPC, which are diisopropylfluorophosphate (a), isopropylfluorophosphoric acid (b) and fluorophosphoric acid (c), extending the complex 1 reactivity to the nerve gas sarin (sa). The reaction concerns the leaving of fluoride from OPC, to produce relative defluorinated phosphates and the (iPrPNHP)Mn(CO)2(F) complex. Analysis of the calculations revealed that the reaction is favored from both thermodynamic and kinetical points of view for a substrate. Our results are in agreement with the available experimental data and represent a further confirmation of versatility of such metal‐complex to interact with P−F containing toxic agents.
Dynamic Instability Mechanism and Stress Staged Evolution of Gob‐Side Entry During Cross‐Fault Mining for Thick Coal Seam
Authors: Liu Xuesheng , Gao Yudong , Shi Zhihan , Li Xuebin , Pei Hongxi , Zhang Yu , Fan Deyuan 
Published: November 2024

ABSTRACTDuring cross‐fault mining, the stress concentration in the surrounding rock of thick coal seam gob‐side entry was prone to dynamic disasters. Based on the in‐site geological conditions of the No. 6305 coal face of the Xinjulong coal mine, a FLAC3D numerical simulation model was established to research the failure and stress staged evolution of coal pillar in the gob‐side entry during cross‐fault mining. By analyzing the relation of surrounding rock structure, the mechanical models of different stages during cross‐fault mining were established. Furthermore, the mechanical mechanism of coal pillars' dynamic instability under the influence of fault activation was revealed, and the mechanical criterion n was given. The control technology of ‘asymmetric strengthening support + roof cutting and pressure relief’ was proposed and designed. Field practice showed that the maximum roof‐to‐floor and two‐side displacements of the gob‐side entry are 249.3 mm and 150.4 mm, and the force of anchor cable is 184.2 kN. This research provided theoretical guidance and reference for the stability control of roadways within the influence range of fault under deep mining conditions.
Charting the Future of Assessments
Authors: Kyllonen Patrick , Sevak Amit , Ober Teresa , Choi Ikkyu , Sparks Jesse , Fishtein Daniel 
Published: November 2024

Assessment refers to a broad array of approaches for measuring or evaluating a person's (or group of persons') skills, behaviors, dispositions, or other attributes. Assessments range from standardized tests used in admissions, employee selection, licensure examinations, and domestic and international large‐scale assessments of cognitive and behavioral skills to formative K–12 classroom curricular assessments. The various types of assessments are used for a wide variety of purposes, but they also have many common elements, such as standards for their reliability, validity, and fairness—even classroom assessments have standards.
We believe the future of assessment will involve a shift in emphasis on what skills will be measured, innovations in how we go about measuring them, the use of advanced technologies for test operations, and an expansion in the value and kinds of information that test takers will receive from taking the assessment.In this paper, we argue and provide evidence for our belief that the future of assessment contains challenges but is promising. The challenges include risks associated with security and exposure of personal data, test score bias, and inappropriate test uses, all of which may be exacerbated by the growing infiltration of artificial intelligence (AI) into our lives. The promise is increasing opportunities for testing to help individuals achieve their education and career goals and contribute to well‐being and overall quality of life. To help achieve this promise we focus on the evidence‐based science of measurement in education and workplace learning, a theme throughout this paper.
Wildland Urban Interface Codes in the USA: Comparison Between the Codes From the International Code Council and the State of California
Authors: Hirschler Marcelo M. 
Published: November 2024

ABSTRACTTwo organizations in the United States have developed codes to protect against the hazards associated with wildfires: the International Code Council (ICC; a private not‐for‐profit organization) and the state of California. Both codes contain strict requirements that, when put into effect, do significantly improve fire safety. The ICC code (IWUIC) has been adopted (either as issued or with amendments) by several states in the USA while the California code (CA Chapter 7A) applies only in that state. There are many similarities between both sets of codes but there are also some clear differences. The most important difference is that CA Chapter 7A allows wood that has not been treated with fire retardants (untreated wood) to be used on decks and walls, while the IWUIC requires the use of materials with improved fire performance for those applications. On the other hand, there are also requirements in CA Chapter 7A that are more conducive to fire safety than the equivalent ones in the IWUIC. One example is the fact that CA Chapter 7A does not permit the use of coated wood materials, in view of the act that all wildland applications involve exterior use and that coatings on wood materials have been shown to be susceptible to suffer fire performance degradation when exposed to weather; IWUIC is silent on that issue, meaning that the use of coated wood materials is not prohibited. The two codes (in the USA only) will be compared and contrasted in this work with respect to delivering improved fire safety.
Multi‐Parameter Investigation of Cretaceous to Palaeocene Sedimentary Sequences in the Anambra and Niger Delta Basins, Nigeria: Organic Matter Characterisation, Palynofacies and Implications for Palaeoclimate and Sea‐Level Changes
Authors: Omietimi Erepamo J. , Lenhardt Nils , Yang Renchao , Götz Annette E. , Edegbai Aitalokhai J. , Bumby Adam J. 
Published: November 2024

ABSTRACTThe Anambra Basin of Nigeria, part of the larger West and Central African Rift System (WCARS) across Africa, contains primarily Cretaceous to Palaeocene shallow to marginal marine and freshwater sedimentary deposits. The organic‐rich deposits of the Cretaceous Nkporo and Mamu formations within the Anambra Basin and the Palaeocene Imo Formation of the Niger Delta Basin constitute important conventional source rocks. Despite its economic significance, research on organic matter characterisation, palynofacies, sea‐level fluctuations, palaeoclimate, hydrogeography, basin restriction, palaeobathymetry and the factors controlling organic matter preservation remains largely undocumented. The here presented new inorganic and organic geochemical and organic petrography data of the Cretaceous to Palaeocene deposits serve to refine the regional interpretation at a basinal scale and within the supra‐regional context of the WCARS. Geochemical palaeotemperature proxies suggest a warm and humid tropical palaeoclimate during the Late Cretaceous within the study area. Furthermore, the measured TOC values indicate poor to very good organic content. Palynofacies analysis revealed high abundances of opaque and translucent phytoclasts and low amounts of palynomorphs with negligible amorphous organic matter (AOM) in the studied mudrocks. Two palynofacies groups suggest shallow‐marine conditions in a proximal shelf setting and a heterolithic oxic basin. The palynofacies of the upper Imo Formation reveal higher percentages of dinoflagellate cysts during the early highstand phase, with equidimensional, opaque phytoclasts representing the maximum flooding phase, accompanied by warmer conditions. Additionally, abundant terrestrial phytoclasts, Deltoidospora spp., Classopollis spp. and geochemical indicators collectively indicate warm tropical climatic conditions consistent with geochemical interpretations. The palaeobathymetry reconstructions suggest a shallow seaway during the Upper Cretaceous in the Anambra Basin.
Modelling Groundwater Hydrological Drought and Its Recovery Given Natural and Anthropogenic Scenarios in South America
Authors: Vega‐Briones Jorge , Sutanudjaja Edwin H. , de Jong Steven , Wanders Niko 
Published: November 2024

ABSTRACTChanges in groundwater recharge are a major concern in areas where increasing irrigated agriculture evidences unsustainable groundwater withdrawals despite low precipitation. This is worsening due to the increasing groundwater demand, which has intensified the magnitude of the hydrological drought by 10%–500%. Globally, 69% of groundwater abstraction is used for agriculture. Hence, South America is expected to face an unprecedented hydrological drought over the next 30 years due to rising agricultural withdrawals. Furthermore, attributing groundwater decline to groundwater pumping is an ongoing challenge (including scientific and technical/modelling challenges) that needs to be robustly addressed. To better understand the influence of anthropogenic water consumption on hydrological drought, with a particular emphasis on how irrigated agriculture impacts groundwater, we compared coupled and non‐coupled versions of PCR‐GLOBWB2.0 with MODFLOW regarding model selection and scenario comparison. We presented a natural and human scenario to understand the effects of hydrological drought on groundwater depletion and recovery. Using scenario comparison, the spatial patterns of human impact on the water cycle are identified by comparing groundwater flows, drought characteristics, and drought recovery. These impacted areas may help to understand their effects on human consumption, food security, and ecosystem demands.
A Cutting‐Edge Hybrid Deep Learning Technique with Low Rank Approximation for Attacks Classification on IoT Traffic Data
Authors: Sharma Ankita , Rani Shalli 
Published: November 2024

ABSTRACTNetwork security is experiencing huge challenges as network attacks on traffic data become more frequent and sophisticated. In this paper, we employ hybrid deep learning models and low‐rank approximation to present a novel method for multi‐label categorization of network assaults on traffic data. Our suggested solution, LR‐CNN‐MLP, consists of three models a multi‐layer perceptron (MLP), a hybrid convolutional neural network (CNN), and a low‐rank approximation model. While the CNN and MLP models extract features and categorize data, respectively, the low‐rank approximation model reduces the input's dimensionality. Overall, by combining hybrid models and low‐rank approximation, our proposed LR‐CNN‐MLP approach provides a promising solution for multi‐label categorization of network attacks on traffic data. LR‐CNN‐MLP achieves the highest results of performance metrics such as 0.944 precision, 0.979 recall, 0.961 F1‐score and 98.17 accuracy.
Literacy in everyday life: How bilingual college students repurposed and adapted literacy spaces
Authors: Foran Timothy M. 
Published: November 2024

AbstractThis study aims to understand how bilingual college students constructed literacy spaces across their lives rather than an in‐school/out‐of‐school dichotomy. Drawing on Lefebvre's (1991) spatial triad as a lens to examine the participants' spatial literacy practices, the findings show that some participants repurposed planned spaces into literacy ones while others relied on the planned aspect of space. Furthermore, adapting spatial literacy practices to meet life and semester demands significantly impacted the participants' ability to compose college essays. This study has implications for college writing instructors because it shows that students' literacy spaces are contingent on the social production of space beyond the physical classroom and calls for a greater emphasis on the role of space in college.
Laboratory Biochemical and Hematological Parameters: Early Predictive Biomarkers for Diagnosing Hepatitis C Virus Infection
Authors: Bagheri Saeede , Fard Ghazaleh Behrouzian , Talkhi Nasrin , Rashidi Zadeh Davoud , Mobarra Naser , Mousavinezhad Seyedmahdi , Khamse Fatemeh Mirzaeian , Hosseini Bafghi Mahdi 
Published: November 2024

ABSTRACTBackgroundHepatitis C virus (HCV) infection is a worldwide concern, causing liver damage and necessitating early detection to prevent its spread. Studies indicate that evaluating changes in biochemical and hematological parameters, which serve as suitable predictors of inflammation, can be a reasonable method for diagnosing hepatitis C infection.MethodsThis study analyzed 100 samples from high‐risk patients positively identified via quantitative real‐time PCR (qPCR). Anti‐HCV titers, biochemical and inflammatory tests, and complete blood cell counts (CBCs) were performed for these individuals. Additionally, 100 HCV‐negative individuals with normal laboratory results were selected as the control group. Receiver operating characteristic (ROC) curves were plotted to determine the cutoff values of the laboratory parameters.ResultsAccording to the findings, the age, average white blood cell (WBC) count, platelet‐to‐lymphocyte ratio (PLR), erythrocyte sedimentation rate (ESR), C‐reactive protein (CRP), lactate dehydrogenase (LDH), total bilirubin (TBIL), direct bilirubin (DBIL), alkaline phosphatase (ALP), serum glutamic‐pyruvic transaminase (SGPT), and ferritin levels were significantly higher in HCV patients. On the other hand, red blood cell (RBC) counts, neutrophils, lymphocytes, hemoglobin‐to‐platelet ratio (HPR), and iron (Fe) levels were significantly lower in the case group compared to those in the control group (p < 0.05). Furthermore, the ROC curve analysis revealed that lymphocyte count, neutrophil count, and PLR were very strong predictors for hepatitis C infection (p < 0.0001, AUC = 1).ConclusionThe study highlights significant biochemical and hematological differences between HCV patients and healthy subjects. These biomarkers are crucial for early diagnosis, potentially preventing liver damage and reducing HCV transmission.