bluuebunny/crossref_metadata_2025_split huggingface dataset:
Anterior Insular Cortex is Critical for the Propensity to Relapse Following Punishment-Imposed Abstinence of Alcohol Seeking
Authors: Campbell Erin J. , Flanagan Jeremy P.M. , Walker Leigh C. , Hill Mitchell K.R.I. , Marchant Nathan J. , Lawrence Andrew J. 
Published: December 2018

Humans with alcohol use disorder typically abstain because of the negative consequences associated with excessive drinking, and exposure to contexts previously associated with alcohol use can trigger relapse. We used a rat model that captures a characteristic of this human condition: namely voluntary abstinence from alcohol use because of contingent punishment. There is substantial variability in the propensity to relapse following extended periods of abstinence, and this is a critical feature preventing the successful treatment of alcohol use disorder. Here we examined relapse following acute or prolonged abstinence. In male alcohol preferring P rats, we found an increased propensity to relapse in Context B, the punishment context after prolonged abstinence. Next, we found that neither alcohol intake history nor the motivational strength of alcohol predicted the propensity to relapse. We next examined the putative circuitry of context-induced relapse to alcohol seeking following prolonged abstinence using Fos as a marker of neuronal activation. The anterior insular cortex (AI) was the only brain region examined where Fos expression correlated with alcohol seeking behavior in Context B after prolonged abstinence. Finally, we used local infusion of GABAAand GABABreceptor agonists (muscimol + baclofen) to show a causal role of the AI in context-induced relapse in Context B, the punishment context after prolonged abstinence. Our results show that there is substantial individual variability in the propensity to relapse in the punishment-associated context after prolonged abstinence, and this is mediated by activity in the AI.SIGNIFICANCE STATEMENTA key feature of alcohol use disorder is that sufferers show an enduring propensity to relapse throughout their lifetime. Relapse typically occurs despite the knowledge of adverse consequences including health complications or relationship breakdowns. Here we use a recently developed rodent model that recapitulates this behavior. After an extended period of abstinence, relapse propensity is markedly increased in the “adverse consequence” environment, akin to humans with alcohol use disorder relapsing in the face of adversity. From a circuitry perspective, we demonstrate a causal role of the anterior insular cortex in relapse to alcohol seeking after extended abstinence following punishment imposed voluntary cessation of alcohol use.
EMPLOYEE INNOVATION RESILIENCE: A PROPOSAL FOR MULTIDIMENSIONAL CONSTRUCT
Authors: Aslan Gonca , Araza Aylin 
Published: December 2018

As being one of the prominent phenomenon in ecology, engineering and pyschology studies for more than thirty years, resilience has started to gain attraction and attention in management and organization fields in the last decade. The concept is accepted as an antidote of invulnerability (Weick, 1993), adaptive functioning against risk hazards (Rutter, 1987) and ability to cope with multiple changes (Boyd and Folke, 2012). Resilience is either defined as set of available and accessible behaviors over time that reflects growth (Ungar; 2010,2011) or as the maintenance of positive adjustment under challenging conditions (Vogus and Sutcliffe, 2007), it fosters the strenght and the survival of the organism. Resilience could be accepted in its infancy in management and organization studies, however, it has a grand potential to understand how employees in organizations endure ongoing changes, challenges and uncertainty that reveal through innovation and its potential effects on innovation performance. Due to lack of any measurement scale in employee innovation resilience, in this study,,we aim at proposing a model that presents innovation resilience as a second order multidimensional construct that consists of three dimensions and three sub-dimensions of each observable variables.
YENİ KAMU YÖNETİMİ VE KÜRESEL YÖNETİŞİM KAPSAMINDA TÜRKİYE’DE KALKINMA GAZETECİLİĞİ
Authors: SARAY Gülsen , KOFOĞLU Taner 
Published: December 2018

The purpose of this study is to examine the press within the framework of 'development journalism', a kind of journalism which is responsible for informing the public about the administrative changes and transformation processes experienced by the country, by considering the implementation of ‘new public management’ concept in Turkey within the domain of the ‘global governance’ and ‘globalization’ phenomenon affecting the nation states. It was assumed in the design of the study that long or short term social problems could only be observed in a time tunnel and that the dense break points were spread over time. When some anti-systematic tendencies are examined in the historical process, it can be seen that the order settled in the administrative area can be suddenly reversed by causal relation. Issues in the background of the current problems in Turkey, has been characterized by a feature of uncertainty under the influence of populist politics that have been exhibited over time by different governments coming to power since the cold war. There are many reasons for the historical background of some of the disruptions seen in the administrative application practices of the new public administration approach. These include the late arrival of modernism to Turkey; followed by dependence on international aid programs under the US and EU; being a party to international economic and military agreements; the time required to adapt the definitions of internal law to domestic law; informing citizens about the change and assimilating the transformation. There fore the relations between 'administration and the media' have been tried to be handled in connection with the global order. In many non-Western countries, utilitarian practices of the new governance conception that developed after the abandonment of open or hidden colonial practices have also created an impact on the development of journalism and the differentiation of journalism genres. 'Development journalism' has played an important role in reflecting public administrative changes in Turkey to the public, which was never subjected to colonial rule by the West. In this study, only a descriptive situation is detected. It is expected to be useful for studies on the ‘administration’ and the media relations to be carried out later, during the change and transformation process of Turkey to a presidential system. 'Governance’ and media relations are handled together within the scope of new public administration practices and ‘global governance’ concept, which makes this work original.
The Genetic Basis of Mutation Rate Variation in Yeast
Authors: Gou Liangke , Bloom Joshua S , Kruglyak Leonid 
Published: December 2018

Abstract
Mutations are the root source of genetic variation and underlie the process of evolution. Although the rates at which mutations occur vary considerably between species, little is known about differences within species, or the genetic and molecular basis of these differences. Here, we leveraged the power of the yeast Saccharomyces cerevisiae as a model system to uncover natural genetic variants that underlie variation in mutation rate. We developed a high-throughput fluctuation assay and used it to quantify mutation rates in seven natural yeast isolates and in 1040 segregant progeny from a cross between BY, a laboratory strain, and RM, a wine strain. We observed that mutation rate varies among yeast strains and is heritable (H2 = 0.49). We performed linkage mapping in the segregants and identified four quantitative trait loci underlying mutation rate variation in the cross. We fine-mapped two quantitative trait loci to the underlying causal genes, RAD5 and MKT1, that contribute to mutation rate variation. These genes also underlie sensitivity to the DNA-damaging agents 4NQO and MMS, suggesting a connection between spontaneous mutation rate and mutagen sensitivity.
Ovarian Dysgerminoma with Metastases in Supraclavicular Lymph Nodes Diagnosed in a 16-year-old Girl: Clinical Case and Literature Review
Authors: Maldžiūtė Diana , Rukauskaitė Vilma , Trainavičius Kęstutis 
Published: December 2018

[full article, abstract in English; abstract in Lithuanian]
Background
Tumors of children reproductive system are rare, the most frequent among them is ovarian tumor. The most frequent histological type of ovarian tumor in girls and adolescents is germ cell tumor, with dysgerminoma being the most frequent of all. Symptoms are very non-specific, this is why these tumors are often diagnosed late. Dysgerminoma is a malignant tumor, thus if not treated, it may be potentially lethal.
Case report
We present a 16-year old patient, who has come to Vilnius University Hospital Santaros Klinikos, Children’s unit, due to a sudden emergence of a growth above the left clavicle. The girl did not have any other specific complaints. Huge hard growth was founded during palpation of the abdomen. After the cancer marker test (alfa-fetoprotein – 1,9 kU/L, beta-human chorionic gonadotropin – 1231.0 U/L; lactate dehydrogenase – 2721.0 U/L; Ca125 – 665.8 kU/L), pelvic ultrasound examination, computed tomography and histological evaluation of the supraclavicular mass, dysgerminoma of the right ovary FIGO stage IV was diagnosed. The patient was treated with laparotomic oophorectomy and chemotherapy before and after surgery. Treatment was successful as 100% of tumor cells necrosis was achieved.
Conclusions
Girls and adolescents should be suspect to ovarian masses if they complains about abdominal pain, a growth in the abdominal area, disruptions of menstrual cycle or signs of premature puberty. Early diagnosis and treatment of ovarian dysgerminoma have a very good recovery rate in girls and adolescent.
Pengembangan Model Pencegahan Anak-Anak Terminal dari Kekerasan Sosial dengan Pendekatan Berbasis Kekuatan dan Kewirausahaan Sosial
Authors: Wibowo Hery 
Published: December 2018

Social violence is an issue that is always present throughout the life of human civilization. Social violence comes very close to human life in various domains of life. One thing to note from social violence is its potential to make children (and other young people) are victims and perpetrators of violence themselves socially. Social Welfare, actually has several approaches, perspectives and instruments to interact with issues of social violence. However, it is less often discussed in the scientiﬁ c writing. This paper attempts to model the handling of violence through social welfare income and social entrepreneurship. Keywords: kekerasan sosial, pendekatan kesejahteraan, social entrepreneurship.
El compromiso con la racionalidad en el enfoque pragmadialéctico
Authors: Hoyos Morales Jorge Iván 
Published: December 2018

El presente artículo aborda el tópico ‘racionalidad’ en la versión estándar del enfoque pragmadialéctico (PD) de argumentación, que pretende superar la dicotomía, entre los aspectos normativo y descriptivo, existente en los estudios sobre argumentación. Se señala que la pragmadialéctica asume ciertos postulados popperianos al conceptualizar su noción de racionalidad, y dado que también incluye elementos de filósofos como Searle y Grice, se indaga si las ideas de racionalidad de estos filósofos están presentes en el compromiso con la racionalidad de los pragmadialécticos. Por otra parte se da cuenta de algunos nexos entre el pensamiento aristotélico y los tres filósofos señalados con el fin de aclarar la concepción que tienen los pragmadialécticos acerca de la racionalidad, estimulando así un regreso enriquecedor a las fuentes de la argumentación.
Wielowymiarowa analiza statystyczna w badaniach rynku kapitałowego
Authors: Budny Katarzyna , Tatar Jan 
Published: December 2018

In their previous work, the authors have presented an approach to describing and researching multivariate probability distributions that departs from the standard. In this paper, the new tools that resulted have been used to research and analyse selected two-, three- and fourth-dimension random vectors that have appeared on the Polish capital market. Coordinates of these vectors are stock market indices: WIG, WIG-20, WIG-Banks, WIG-Fuels and profitability of these indices. Using market data for the period 4/1/16–7/7/17, the following estimators of parameters of analysed distributions were calculated and interpreted: expected value, total variance, total standard deviation, skewness coefficient, norm of the skewness coefficient, square of the skewness coefficient, kurtosis and excess coefficient. In order to overview and compare, for each vector a covariance matrix and a matrix of correlation coefficients are indicated. The following characteristics of marginal distributions are also used: expected value, variance, standard deviation, skewness coefficient, kurtosis and excess coefficient. For each pair of financial random vectors researched, the estimator of the square of correlation coefficient was also calculated, as that is one of the possible measures of their dependence.
Commercialisation of Pickering Emulsions
Authors: Rodrigues Jhonny 
Published: December 2018

This event, hosted by the Royal Society of Chemistry, was held at Burlington House, London, UK, on 23rd November 2017. There was a good attendance with 55 delegates from academia and industry, mainly from the UK. A brief overview of some of the presentations is described here to give a flavour of recent progress in this area.
The first session was called ‘Control of Pickering Emulsions’. Professor Bernard P. Binks (University of Hull, UK) reviewed the fundamentals of solid-stabilised emulsions with the use of inorganic silica particles, whereas Professor Steven P. Armes (University of Sheffield, UK) extended the topic with the use of polymer particles.
Política migratoria y seguridad en Argentina hoy: ¿el paradigma de derechos humanos en jaque?/ Migration policy and security in Argentina today: human rights paradigm in jeopardy?
Authors: Penchaszadeh Ana Paula , García Lila Emilse 
Published: December 2018

Este artículo tiene por objetivo abordar los recientes cambios operados en la política migratoria argentina, con especial énfasis en las modificaciones introducidas por el Decreto de Necesidad y Urgencia (DNU) 70 (de enero de 2017), con vistas a iluminar los vínculos actuales entre migraciones, derechos humanos y seguridad. El caso argentino resulta de especial interés porque la Ley Migratoria vigente desde 2004 incorpora importantes estándares de derechos humanos, que deberían funcionar como límite al avance de ciertas prerrogativas soberanas del Estado en nombre la seguridad. Las distintas medidas adoptadas por el Gobierno de la alianza Cambiemos, desde su llegada al poder en 2015, se basaron en una vinculación directa entre migración y criminalidad, dirigida a reinscribir la política migratoria en el terreno de la seguridad y a enfatizar el control, en detrimento de la integración de las personas migrantes. Creemos que el DNU 70 tiene un carácter ejemplar para el análisis específico de las paradojas que entraña la criminalización de las migraciones, con el consecuente avance de la excepcionalidad soberana, en un contexto normativo de reconocimiento de los derechos humanos. Sobre estas tensiones versa el presente artículo, con la expectativa de que este caso pueda alumbrar otros similares.
Abstract
The goal of this paper is to address recent changes over Argentine migration policy, particularly reforms introduced by the Necessity and Urgency Decree (Decreto de Necesidad y Urgencia-DNU) 70, issued by the executive branch in January 2017, to highlight the current links between migrations, human rights and security. Argentina’s case is of the most importance given that its Migration Law (from 2004) has recognized the highest standards on human rights, which should limit certain actions of the State taken in the name of security. Measures adopted by Cambiemos government (a right based coalition that won in 2015) are based on a direct linkage between migration and criminality, intended to rewrite migration policy in the field of security to emphasize control, instead of social integration of migrants. In this frame, we believe DNU 70 set an example that allows analyzing the paradox encompasses in the criminalization of migrations, with consequences such as more exceptionalism in sovereignty, even though in a context of general recognition of human rights. This article goes about these tensions expecting Argentina’s case may illuminate others.
De la era de la migración al siglo de la seguridad: el surgimiento de “políticas de control con rostro (in)humano”/ From the age of migration to the century of security: the emergence of ‘control policy with a (in)human face’
Authors: Ramírez Jaques 
Published: December 2018

Si bien el discurso oficial, aceptado prácticamente por todos los Estados, habla de una migración “regular, ordenada y segura”, lo cual ha quedado sellado en el Pacto Global de las Migraciones, la movilidad humana contemporánea difiere mucho del deseo de los gobernantes, tanto en el perfil como en las vías utilizadas para llegar al destino. El presente artículo pasa revista a algunos “paisajes migratorios” en varios lugares del planeta, que han tenido como correlato la respuesta estatal de mayores controles, apelando al discurso de la soberanía nacional. Se plantea la tesis de que en esta nueva etapa del neoliberalismo estamos presenciando el surgimiento de políticas de control con rostro (in)humano de carácter neofascista, sobre todo con el ascenso al poder de Gobiernos nacionalistas y de extrema derecha, que impulsan y practican la xenofobia, el racismo y la aporofobia. Esto ha resultado en un incremento de la deportación, judicialización de la migración, expulsión, confinamiento, construcción de muros, extorsiones, secuestros, desapariciones, tortura y muerte.
Abstract
Although the official discourse, accepted practically by all the States, speaks of a "regular, orderly and safe" migration, which has been sealed in the Global Compact for Migration, contemporary human mobility differs greatly from the desire of the rulers both in the profile and in the routes used to reach destination. This article reviews a number of 'migratory landscapes' in several places on the planet that have had as a correlate the State´s response to greater controls, appealing to the discourse of national sovereignty. The following thesis is proposed: that in this new stage of neoliberalism we are witnessing the emergence of control policy with an (in) human face of neo-fascist character, especially with the rise to power of nationalist and far-right governments that promote and practice xenophobia, racism and aporophobia. This has resulted in increased deportation, judicialization of migration, expulsion, confinement, construction of walls, extortion, kidnapping, disappearances, torture and death.
THE ROLE OF ORTHOSTATIC TEST IN PROGNOSIS OF ARTERIAL HYPERTENSION DEVELOPMENT IN YOUNG ADULTS
Authors: Sklyannaya E. V. 
Published: December 2018

The aimof this study was to assess the role of orthostatic test in prognosis of arterial hypertension (AH) in young adults.Materials and methods.842 young adults 20–29 years old with the level of blood pressure (BP) <140/90 mm Hg were enrolled in a prospective study. Active orthostatic test was performed. Observation period was 5 years. After that 2 groups were assigned according to BP level: group 1 – with AH (BP level >140/90 mm Hg), group 2 – with normal BP level (<140/90 mm Hg).Results.Physiological type of orthostatic reaction was found in 542 persons (64.4 %), primary hypersympathicotonic type – in 79 (9.4 %), secondary hypersympathicotonic – in 93 (11.1 %), hyposympathicotonic – in 94 (11.2 %), sympathicoasthenic – in 34 (4.0 %). 78 persons were withdrawn from the study for different reasons during observation period. AH was diagnosed in 144 (18.8 %) persons (group 1), normal BP – in 620 (81.2 %) participants (group 2). In group 1 hypersympathicotonic response to orthostatic test was observed in 102 (70.8 %) persons, in group 2 – in 47 (7.6 %) participants (р <0,001). By the results of univariate logistic regression analysis male sex (OR 10.8; 95 % CI 7.6–15.3), body mass index >25 kg/m2 (OR 7.2; 95 % CI 5.7–9.1), smoking (OR 5.6; 95 % CI 4.5–7.0), high normal BP (OR 10.7; 95 % CI 6.9–14.5) and hypersympathicotonic orthostatic response (OR 13.6; 95 % CI 10.0–18.7) were significant risk factors of AH. By the results of multivariate analysis body mass index >25 kg/m2, high normal BP and hypersympathicotonic orthostatic response were independent risk factors.Conclusion.Hypersympathicotonic orthostatic response with increased body mass index and high normal BP are the risk factors of AH development during next 5 years in young adults. It is reasonable to use orthostatic test in assessing the risk of AH development in young people.
Medical rehabilitation of patients with urinary incontinence
Authors: Satybaldyev Sh. R. , Satybaldyeva E. Sh. , Evdokimov V. V. 
Published: December 2018

The study objectiveis to evaluate the effectiveness of physiotherapy, therapeutic gymnastics and psychotherapy in the medical rehabilitation of patients with different types of urinary incontinence (UI).Materials and methods.In the departments of urology of the Kyrgyz Research Institute of Balneology and Rehabilitation were treated 164 patients with UI. Patients were divided into groups depending on the type of treatment: 132 patients were included in the treated group (UI developed as a complication of prostatectomy in 90 of them, as a complication of chronic cystitis – in 42), who used drug therapy and rehabilitation complexes. In 32 patients, only traditional drug therapy was performed, they formed a comparison group.Results.There was a significant improvement in the clinical characteristics: the severity of pain, frequent urination, UI decreased after rehabilitation treatment by 1.5–2.0 points, after traditional treatment – by 0.3–0.8 points. The average number of UI episodes decreased by 48 % compared to the baseline, the volume of urination increased by 37 %. Urination rate decreased by 55 %. The clinical effect of rehabilitation complexes was confirmed by subjective sensations recorded in the SF-36 questionnaire.Conclusion.Complex influence (the differentiated application of physiotherapy, physiotherapy in combination with psychotherapy, electrostimulation and magnetotherapy) caused high clinical level of rehabilitation.
Peculiarities of physical and sexual development of boys in the onset of puberty in different ecologo-geographical regions of the Republic of Dagestan
Authors: Kamalov K. G. , Gazimagomedov G. A. , Magomedova I. M. 
Published: December 2018

The study objectiveis to compare the characteristics of physical and sexual development of boys aged 11–13 years living in different ecological and geographical areas of the Republic of Dagestan and to determine the effect of chronic iodine deficiency on the onset of puberty.Materials and methods. In a lowland area containing 11 districts, 501 subjects were examined; in a mountain area containing 17 districts, 325 subjects were examined; in a submontane area containing 7 districts, 274 subjects were examined. In total, 1100 boys aged 11–13 years were randomly selected.Results.Physical development of the boys was mostly characterized as normal but with a clear tendency toward lower values, especially in the submontane districts. In boys living in the areas with severe iodine deficiency, delayed onset of puberty was observed 3.2 times more frequently than in their counterparts living in the districts with mild iodine deficiency. Total fraction of boys with signs of delayed sexual development was 38.5 %, and they mostly lived in the submontane area.Conclusion.Emerging in Russia tendency toward lowered characteristics of physical development of boys is observed in the Republic of Dagestan. This confirms the negative effect of chronic iodine deficiency on sexual development of boys which manifests through delayed sexual maturity.