bluuebunny/crossref_metadata_2025_split huggingface dataset:
A review of Karl Maton, Susan Hood & Suellen Shay (eds.), Knowledge Building: Educational Studies in Legitimation Code Theory, Abingdon and New York: Routledge, 2016. xvii + 264 pp., US$160.00 (hbk)
Authors: Liu Yan , Yu Hui 
Published: October 2018

AbstractAs educational linguistic researchers, we seek to explore the relations between language, society, knowledge and education. This current volume appeals to us since its efforts coincide with our research interest. It addresses two weaknesses commonly found in research into education and society: knowledge blindness and segmentalism. Part I demonstrates reflexively how LCT as an explanatory framework could be applied to overcome segmentalism. Part II applies LCT to six studies through uncovering the underlying principles of knowledge practice. Part III includes an architectural glossary. We conclude by discussing the strengths and insufficiencies of the volume. Despite the insufficiencies, this volume will prove to be a lasting inspiration for readers of different fields.
Androgen Receptor and ALDH1 Expression Among Internationally Diverse Patient Populations
Authors: Jiagge Evelyn , Jibril Aisha Souleiman , Davis Melissa , Murga-Zamalloa Carlos , Kleer Celina G. , Gyan Kofi , Divine George , Hoenerhoff Mark , Bensenhave Jessica , Awuah Baffour , Oppong Joseph , Adjei Ernest , Salem Barbara , Toy Kathy , Merajver Sofia , Wicha Max , Newman Lisa 
Published: October 2018

Purpose Population-based incidence rates of breast cancers that are negative for estrogen receptor (ER), progesterone receptor, and human epidermal growth factor receptor 2/ neu (triple-negative breast cancer [TNBC]) are higher among African American (AA) compared with white American (WA) women, and TNBC prevalence is elevated among selected populations of African patients. The extent to which TNBC risk is related to East African versus West African ancestry, and whether these associations extend to expression of other biomarkers, is uncertain. Methods We used immunohistochemistry to evaluate estrogen receptor, progesterone receptor, human epidermal growth factor receptor 2/ neu, androgen receptor and aldehyde dehydrogenase 1 (ALDH1) expression among WA (n = 153), AA (n = 76), Ethiopian (Eth)/East African (n = 90), and Ghanaian (Gh)/West African (n = 286) patients with breast cancer through an institutional review board–approved international research program. Results Mean age at diagnosis was 43, 49, 60, and 57 years for the Eth, Gh, AA, and WA patients, respectively. TNBC frequency was higher for AA and Gh patients (41% and 54%, respectively) compared with WA and Eth patients (23% and 15%, respectively; P < .001) Frequency of ALDH1 positivity was higher for AA and Gh patients (32% and 36%, respectively) compared with WA and Eth patients (23% and 17%, respectively; P = .007). Significant differences were observed for distribution of androgen receptor positivity: 71%, 55%, 42%, and 50% for the WA, AA, Gh, and Eth patients, respectively ( P = .008). Conclusion Extent of African ancestry seems to be associated with particular breast cancer phenotypes. West African ancestry correlates with increased risk of TNBC and breast cancers that are positive for ALDH1.
The Adrenal Clock Prevents Aberrant Light-Induced Alterations in Circadian Glucocorticoid Rhythms
Authors: Engeland William C , Massman Logan , Mishra Shubhendu , Yoder J Marina , Leng Sining , Pignatti Emanuele , Piper Mary E , Carlone Diana L , Breault David T , Kofuji Paulo 
Published: October 2018

Abstract
The glucocorticoid (GC) rhythm is entrained to light-dark (LD) cycles via a molecular clock in the suprachiasmatic nucleus (SCN) and is maintained by an adrenal clock synchronized by SCN-dependent signals. Targeted deletion of the core clock gene Bmal1 can disrupt adrenal clock function. The requirement of the adrenal clock to stabilize the circadian GC rhythm during exposure to aberrant LD cycles was determined using novel aldosterone synthase (AS)Cre/+::Bmal1Fl/Fl mice in which Bmal1 deletion occurred during postnatal adrenal transdifferentiation. To examine whether adrenal Bmal1 deletion results in loss of the adrenal clock, mice were crossed with mPER2::Luciferase (mPER2Luc/+) mice. Adrenals from ASCre/+::Bmal1+/+::PER2Luc/+ [control (CTRL)] mice show mPER2Luc rhythms ex vivo, whereas slices from ASCre/+::Bmal1Fl/Fl::PER2Luc/+ [knockout (KO)] mice show dampened rhythms. To monitor corticosterone rhythmicity, mice were implanted with subcutaneous microdialysis probes and sampled at 60-minute intervals for up to 3 days under 12:12-hour [τ (T) 24] LD or 3.5:3.5-hour (T7) LD cycles. Corticosterone rhythms were entrained to T24 LD in CTRL and KO mice. Under T7 LD, circadian corticosterone rhythms persisted in most CTRL mice but not KO mice. Hyperadrenocorticism also was observed in KO mice under T7 LD, reflected by increased corticosterone peak amplitude, total daily corticosterone, and responses to ACTH. Analysis of dysregulated adrenal genes in KO mice exposed to aberrant light identified candidates involved in cholesterol metabolism and trafficking, including steroidogenic acute regulatory protein, which could increase steroidogenesis. Our results show that the adrenal clock functions to buffer steroidogenic responses to aberrant light and stabilize circadian GC rhythmicity.
A New Multisystem Disorder Caused by the Gαs Mutation p.F376V
Authors: Biebermann Heike , Kleinau Gunnar , Schnabel Dirk , Bockenhauer Detlef , Wilson Louise C , Tully Ian , Kiff Sarah , Scheerer Patrick , Reyes Monica , Paisdzior Sarah , Gregory John W , Allgrove Jeremy , Krude Heiko , Mannstadt Michael , Gardella Thomas J , Dattani Mehul , Jüppner Harald , Grüters Annette 
Published: October 2018

Abstract

Context
The α subunit of the stimulatory G protein (Gαs) links numerous receptors to adenylyl cyclase. Gαs, encoded by GNAS, is expressed predominantly from the maternal allele in certain tissues. Thus, maternal heterozygous loss-of-function mutations cause hormonal resistance, as in pseudohypoparathyroidism type Ia, whereas somatic gain-of-function mutations cause hormone-independent endocrine stimulation, as in McCune-Albright syndrome.

Objective
We report two unrelated boys presenting with a new combination of clinical findings that suggest both gain and loss of Gαs function.

Design and Setting
Clinical features were studied and sequencing of GNAS was performed. Signaling capacities of wild-type and mutant Gαs were determined in the presence of different G protein–coupled receptors (GPCRs) under basal and agonist-stimulated conditions.

Results
Both unrelated patients presented with unexplained hyponatremia in infancy, followed by severe early onset gonadotrophin-independent precocious puberty and skeletal abnormalities. An identical heterozygous de novo variant (c.1136T&gt;G; p.F376V) was found on the maternal GNAS allele in both patients; this resulted in a clinical phenotype that differed from known Gαs-related diseases and suggested gain of function at the vasopressin 2 receptor (V2R) and lutropin/choriogonadotropin receptor (LHCGR), yet increased serum PTH concentrations indicative of impaired proximal tubular PTH1 receptor (PTH1R) function. In vitro studies demonstrated that Gαs-F376V enhanced ligand-independent signaling at the PTH1R, LHCGR, and V2R and, at the same time, blunted ligand-dependent responses. Structural homology modeling suggested mutation-induced modifications at the C-terminal α5 helix of Gαs that are relevant for interaction with GPCRs and signal transduction.

Conclusions
The Gαs p.F376V mutation causes a previously unrecognized multisystem disorder.
A unified GenomeSpace recipe to identify essential genes and associated subnetworks from Genome-Scale CRISPR-Cas9 knockout screens
Authors: Carlin Daniel E. , Kim Forrest , Ideker Trey , Mesirov Jill P. 
Published: October 2018

We present a unified GenomeSpace recipe that combines the results of a high throughput CRISPR genetic screen and a biological network to return a subnetwork that suggests a mechanistic explanation of the screen’s results. The explanatory subnetwork is found by network propagation, a popular systems biology approach. We demonstrate our pipeline on an alpha toxin screen, revealing a subnetwork that is both highly interconnected and highly enriched for hits in the screen.
Potensi Metabolit Sekunder Asal Bakteri Endofit dalam Menekan Pertumbuhan Miselium Ganoderma boninense
Authors: Widiantini Fitri , Nasahi Ceppy , Yulia Endah , Noviyawati Serly 
Published: October 2018

Potency of Endophytic Bacterial Secondary Metabolite to Inhibit Mycelium Growth of Ganoderma boninense Endophytic bacteria have a close relationship with their host plants. The bacteria are living inside their host without causing any symptom. Endophytic bacteria are well known for their ability to produce compounds that can be used to protect plants from deleterious microorganisms. The research was conducted to determine the ability of endophytic bacteria in producing antifungal compounds that are able to suppress the growth of Ganoderma boninense, a causal agent of basal stem rot disease of oil palm. Previously isolated endophytic bacteria were grown on international streptomyces project 2 (ISP2) liquid medium and incubated at rotary evaporator at 120 rpm for 10 days. The supernatant was separated from bacterial cells and tested against G. boninense using well diffusion agar method. The results showed that endophytic bacteria isolate of BEK6, BEK7, BEK9 and BEK10 were able to produce antifungal compound against G. boninense. Microscopic observation demonstrated G. boninense mycelia alteration following secondary metabolite application.
Deteksi Cepat Fusarium sp. pada Benih Kedelai Menggunakan Metode Spektroskopi Fluoresens
Authors: Pujiarto Djoko , Soekarno Bonny Poernomo Wahyu , Maddu Akhiruddin 
Published: October 2018

Rapid Detection Method for Fusarium sp. on Soybean Seed Using Fluorescence Spectroscopy MethodSeed borne pathogens play an important role as source of inoculum for disease in the field. Seed health testing is applied in order to prevent risks caused by seed borne pathogen. Fluorescence spectroscopy is a potential technology to be used as detection method for seed borne pathogen. Research was conducted to develop rapid detection protocol for seed borne pathogenic fungus by fluorescence spectroscopy method. The result showed that fluorescence spectroscopy could detect fluorescence emission of metabolite of Fusarium sp. after soybean seeds were incubated for 24 hr. Metabolite of Fusarium sp. produced cyan fluorescent at peak wavelength emission 504 nm when excited to violet light (405 nm). Fusarium sp. displayed typical fluorescence emission spectra which differ from fluorescence emission spectra of growth medium potato dextrose broth (PDB) (502 nm). It was evidenced that fluorescence spectroscopy method can be used to detect pathogenic seed borne fungi.
REALISASI TUJUAN PENGELOLAAN ZAKAT BERDASARKAN UNDANG-UNDANG NO. 23 TAHUN 2011 MELALUI PROGRAM ZAKAT COMMUNITY DEVELOPMENT (ZCD) PADA MASYARAKAT DESA SINDANGLAKA KABUPATEN CIANJUR
Authors: Solihah Cucu , Mulyadi M. Budi 
Published: October 2018

Keberhasilan zakat sangat ditentukan dari realisasi pendayagunaan zakat melalui program zakat community development (ZCD) Sehubungan dengan hal tersebut, maka permasalahan dalam penelitian ini difokuskan pada realisasi tujuan pengelolaan zakat berdasarkan Undang-Undang No. 23 Tahun 2011 melalui program Zakat Community Development (ZCD) pada masyarakat Desa Sindanglaka .Kabupaten Cianjur dan mengukur tingkat keberhasilan program melalui modal usaha bergulir zakat produktif terhadap kesejahteraan masyarakat. Penelitian ini menggunakan pendekatan yuridis normatif berupa analisis deskriptif. Sumber data yang digunakan adalah data primer yang berupa wawancara dengan pengurus BAZNAS Kabupaten Cianjur juga masyarakat penerima program. Zakat community development (ZCD) memberi pengaruh bagi masyarakat miskin pedesaan untuk melakukan usaha dari modal zakat Produktif dan merubah status mustahik (penerima Zakat) menjadi munfik (pemberi zakat) sehingga zakat mampu menanggulangi permasalahan kemiskinan dan meningkatkan kesejahteraan.
Update on effects of cleaning agents on allergy and asthma
Authors: Prasad Shivonne , Lipszyc Joshua C. , Tarlo Susan M. 
Published: October 2018

Background: Cleaning and disinfecting agents are widely used in modern life, in homes, schools, public places, and workplaces as well as in recreational facilities such as swimming pools. Use has been for sanitizing purposes and to assist in reduction of infection as well as for deodorizing purposes. However, adverse respiratory effects have been associated with use of cleaning products ranging from effects in infancy and early childhood up to adults at home and work. Methods: This review summarizes recent published literature on the effects of cleaning agents used pre-natally, in childhood and adult life, at home, work, and in swimming pools. Results: Several studies have indicated that there is an increased risk of developing asthma among adults with frequent exposure to cleaning products at work and in the home. Potential mechanisms include sensitization and respiratory irritant effects. Exposure to irritant chlorine by-products from swimming pools have also been associated with respiratory effects and increased risk of asthma. Potential effects from maternal exposures to cleaning products on infants, and effects on early childhood atopy are less clear. Conclusions: Exposure to cleaning agents increases relative risks of asthma among workers, and adults using these agents in the home. Risks are also increased with exposure to chlorinated by-products from swimming pools, both in adults and children. Further studies are needed to understand the mechanisms of these associations.
Noncoercive resonant (p,2)-equations with concave terms
Authors: Papageorgiou Nikolaos S. , Zhang Chao 
Published: October 2018

AbstractWe consider a nonlinear Dirichlet problem driven by the sum of ap-Laplace and a Laplacian (a(p,2){(p,2)}-equation). The reaction exhibits the competing effects of a parametric concave term plus a Caratheodory perturbation which is resonant with respect to the principle eigenvalue of the Dirichletp-Laplacian. Using variational methods together with truncation and comparison techniques and Morse theory (critical groups), we show that for all small values of the parameter, the problem has as least six nontrivial smooth solutions all with sign information (two positive, two negative and two nodal (sign changing)).
Large platelet size is associated with poor outcome in patients with metastatic pancreatic cancer
Authors: Lembeck Anna L. , Posch Florian , Klocker Eva V. , Szkandera Joanna , Schlick Konstantin , Stojakovic Tatjana , Kornprat Peter , Lackner Caroline , Gerger Armin , Stoeger Herbert , Stotz Michael , Pichler Martin 
Published: October 2018

Abstract

Background
Platelets are a major cellular component of blood and their interaction with cancer cells is well-established to influence cancer progression and metastases. The physical size of platelets may have a critical impact on the interaction with cancer cells. In this study, we explored the potential prognostic role of platelet size measured by the determination of the mean platetlet volume (MPV) in patients with pancreatic ductal adenocarcinoma (PDAC).

Methods
Data from 527 patients with PDAC diagnosed and treated between 2004 and 2015 at a single center were evaluated retrospectively. Associations between MPV and baseline covariates were assessed with Wilcoxon’s rank-sum tests, χ2-tests, and Fisher’s exact tests. Median follow-up was estimated with a reverse Kaplan-Meier estimator according to Schemper and Smith. Analysis of time-to-death was performed with Kaplan-Meier estimators, log-rank tests and uni- and multivariable Cox proportional hazards models.

Results
The median MPV was 10.5 femto liter (fL) [9.8–11.3], ranged from 5.9 to 17.7 fL. A large platelet volume was associated with high-grade G3/4 tumors (p=0.004) and worse overall survival (OS) in patients with metastatic disease in univariable analysis (hazard ratio [HR] per fL increase in MPV=1.13 [95% CI: 1.04–1.23, p=0.005]). In multivariable analysis of metatatic PDAC patients, the adverse association between large platelets and a higher risk-of-death prevailed (adjusted HR per doubling of MPV=2.00; 95% CI: 1.10–3.62, p=0.02).

Conclusions
Large platelets represent a negative prognostic factor and add an independent prognostic information to well-established factors in PDAC patients. MPV should be considered for future individual risk assessment in patients with stage IV PDAC.
Locally compact groups with totally disconnected space of subgroups
Authors: Hamrouni Hatem , Kadri Bilel 
Published: October 2018

Abstract
The closed subsets

ℱ
⁢

(
X
)

{\mathcal{F}(X)}

of any topological space can be given a topology, called the
Chabauty–Fell topology, in which

ℱ
⁢

(
X
)

{\mathcal{F}(X)}

is quasi-compact. If X is a locally
compact space, then

ℱ
⁢

(
X
)

{\mathcal{F}(X)}

is Hausdorff. If

X
=
G

{X=G}

is a locally compact group, then
the subset

𝒮
⁢
𝒰
⁢
ℬ
⁢

(
G
)

{\mathcal{S\kern-0.853583ptU\kern-0.569055ptB}(G)}

of closed subgroups is closed in

ℱ
⁢

(
G
)

{\mathcal{F}(G)}

, and the set of closed subgroups
inherits its own compact topology, called the
Chabauty topology.
We develop some of the important properties of this topology. More precisely,
the results contained in this paper deal with the following
question: Given a locally compact topological group, when is

ℱ
⁢

(
G
)

{\mathcal{F}(G)}

(resp.

𝒮
⁢
𝒰
⁢
ℬ
⁢

(
G
)

{\mathcal{S\kern-0.853583ptU\kern-0.569055ptB}(G)}

) a totally disconnected space?
Conjugacy classes of centralizers in unitary groups
Authors: Bhunia Sushil , Singh Anupam 
Published: October 2018

Abstract
Let G be a group. Two elements

x
,
y

∈
G

{x,y\in G}

are said to be in the same z-class if their centralizers in G are conjugate within G. Consider

𝔽

{\mathbb{F}}

a perfect field of characteristic

≠
2

{\neq 2}

, which has a non-trivial Galois automorphism of order 2. Further, suppose that the fixed field

𝔽
0

{\mathbb{F}_{0}}

has the property that it has only finitely many field extensions of any finite degree. In this paper, we prove that the number of z-classes in the unitary group over such fields is finite. Further, we count the number of z-classes in the finite unitary group

U
n

⁢

(
q
)

{{\mathrm{U}}_{n}(q)}

, and prove that this number is the same as that of

GL
n

⁢

(
q
)

{{\mathrm{GL}}_{n}(q)}

when

q
>
n

{q>n}

.
Prevalence of overweight and obesity and anthropometric reference centiles for Albanian children and adolescents living in four Balkan nation-states
Authors: Tarp Jakob , Jarani Juel , Muca Florian , Spahi Andi , Grøntved Anders 
Published: October 2018

Abstract

Background
The extent of the obesity epidemic among youth is an important public health statistic which provides an indication of the future burden of non-communicable diseases. Many developing countries, including Albania, do not have systematic and repeated monitoring systems in operation.

Methods
The Balkan Survey of Inactivity in Children study is a population-based cross-sectional survey including Albanian children living in the four Balkan nation-states of Albania, Kosovo, FYR Macedonia and Montenegro. In total, 19,850 children from 49 schools were approached. The LMS method was used to provide body mass index (BMI), height, weight and waist circumference reference centiles for boys and girls. The World Health Organisation (WHO) and International Obesity Task Force (IOTF) age- and sex-specific BMI cut-points were applied to evaluate adiposity levels.

Results
A sample of 18,460 participants aged 6–16 years old was available for creation of the BMI for age and sex reference centiles. The prevalence of overweight (including obesity) in the full sample was 21% (95% CI: 20%–21%) according to IOTF cut-off points and 28% (95% CI: 28%–29%) at WHO cut-off points. Overweight/obesity levels where higher in boys than in girls irrespective of the cut-off points applied (p<0.001). Noticeable between-country differences were observed with a prevalence of overweight/obesity of 40% (95% CI: 38%–42%) in Montenegro but only 20% (95% CI: 19%–21%) in Kosovo (WHO cut-off points).

Conclusions
Overweight/obesity is highly prevalent in Albanian children and adolescents. The apparent sex and country differences may inform public health actions.
An Attempt to Position the German Political Parties on a Tree for 2013 and 2017
Authors: Prisner Erich 
Published: October 2018

Abstract
We try to calculate the position of the six largest German political parties to each other in 2013 and 2017, based on data of Wahl-O-Mat, a German Voting Advice Application. Different to other existing approaches, we do not try to locate these parties in an Euclidean space, but rather on topological trees (with the straight line, the usual left-right model, being the simplest one). This approach has the advantage that – different to two- or higher dimensional spaces – our model allows betweenness information, keeping the parties linearly ordered at least at parts of the tree, with possible conclusions about center or periphery of the political landscape, and possible coalitions. We do not focus primarily on distance but after the topological model is found, we attempt to approximate these distances, in a second step.
Increasing the fermentation efficiency of Lactobacillus paracasei ssp. paracasei MIUG BL6 in a rye flour sourdough
Authors: Cotârleţ Mihaela , Maftei Nicoleta Maricica , Bahrim Gabriela Elena 
Published: October 2018

Abstract

Background
The present study reports the optimization of the biotechnological conditions in order to improve the lactic acid fermentation process, in a rye flour medium by using Lactobacillus paracasei ssp. paracasei strain, coded MIUG BL6, as a starter culture.

Materials and methods
A sequential statistical methodology, comprised of Plackett-Burman experimental design, central composite design and response surface methodology, was applied to enhance the lactic acid fermentation productivity.

Results and discussion
Among the tested parameters, the milk powder and KH2PO4 concentration and also the time of fermentation were identified as the most significant variables that influence the fermentation process. The optimum levels of these significant parameters were determined as follows: 4.21% milk powder, 0.30% KH2PO4 and 48 h of fermentation that induced an increase of 1.6 fold of the acidity, compared to the fermentation conducted under the non-optimized conditions. Also, under these optimized fermentation conditions, a good rate of cell multiplication of 10.19 log N/N0 was achieved.
Hydrothermal growth mechanism of SnO2 nanorods in aqueous HCl
Authors: Leidich Patrick , Mondeshki Mihail , Barton Bastian , Kolb Ute , Panthöfer Martin , Tremel Wolfgang 
Published: October 2018

Abstract
Rutile-type nanorods of SnO2 were obtained in a one-pot hydrothermal synthesis starting from SnCl4·5H2O and HCl in a temperature range between 200 and 240°C. Although the nanorods are polydisperse, the average length of the nanorods could be adjusted from 13 to 65 nm by varying of the reaction temperature. The resulting anisotropic nanocrystals were characterized using powder X-ray diffraction (PXRD), (high resolution-) transmission electron microscopy (HR-TEM), and selected area electron diffraction (SAED). The particle growth proceeds via a dissolution-recrystallization process with soluble [SnCl5(H2O)]− intermediates, as confirmed by PXRD, Raman spectroscopy, and magic angle spinning nuclear magnetic resonance (MAS-NMR).