bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparative modulation of lncRNAs in wild-type and rag1-heterozygous mutant zebrafish exposed to immune challenge with spring viraemia of carp virus (SVCV)
Authors: Valenzuela-Muñoz Valentina , Pereiro Patricia , Álvarez-Rodríguez Margarita , Gallardo-Escárate Cristian , Figueras Antonio , Novoa Beatriz 
Published: October 2019

AbstractAlthough the modulation of immune-related genes after viral infection has been widely described in vertebrates, the potential implications of non-coding RNAs (ncRNAs), especially long non-coding RNAs (lncRNAs), in immunity are still a nascent research field. The model species zebrafish could serve as a useful organism for studying the functionality of lncRNAs due to the numerous advantages of this teleost, including the existence of numerous mutant lines. In this work, we conducted a whole-transcriptome analysis of wild-type (WT) and heterozygousrag1mutant (rag1+/−) zebrafish after infection with the pathogen spring viraemia of carp virus (SVCV). WT andrag1+/−zebrafish were infected with SVCV for 24 h. Kidney samples were sampled from infected and uninfected fish for transcriptome sequencing. From a total of 198,540 contigs, 12,165 putative lncRNAs were identified in zebrafish. Most of the putative lncRNAs were shared by the two zebrafish lines. However, by comparing the lncRNA profiles induced after SVCV infection in WT andrag1+/−fish, most of the lncRNAs that were significantly induced after viral challenge were exclusive to each line, reflecting a highly differential response to the virus. Analysis of the neighboring genes of lncRNAs that were exclusively modulated in WT revealed high representation of metabolism-related terms, whereas those fromrag1+/−fish showed enrichment in terms related to the adaptive immune response, among others. On the other hand, genes involved in numerous antiviral processes surrounded commonly modulated lncRNAs, as expected. These results clearly indicate that after SVCV infection in zebrafish, the expression of an array of lncRNAs with functions in different aspects of immunity is induced.
Binding to medium and long chain fatty acyls is a common property of HEAT and ARM repeat modules
Authors: Li Tie-Mei , Coan John P. , Krajewski Krzysztof , Zhang Lichao , Elias Joshua E. , Strahl Brian D. , Gozani Or , Chua Katrin F. 
Published: October 2019

AbstractCovalent post-translational modification (PTM) of proteins with acyl groups of various carbon chain-lengths regulates diverse biological processes ranging from chromatin dynamics to subcellular localization. While the YEATS domain has been found to be a prominent reader of acetylation and other short acyl modifications, whether additional acyl-lysine reader domains exist, particularly for longer carbon chains, is unclear. Here, we employed a quantitative proteomic approach using various modified peptide baits to identify reader proteins of various acyl modifications. We discovered that proteins harboring HEAT and ARM repeats bind to lysine myristoylated peptides. Recombinant HEAT and ARM repeats bind to myristoylated peptides independent of the peptide sequence or the position of the myristoyl group. Indeed, HEAT and ARM repeats bind directly to medium- and long-chain free fatty acids (MCFA and LCFA). Lipidomic experiments suggest that MCFAs and LCFAs interact with HEAT and ARM repeat proteins in mammalian cells. Finally, treatment of cells with exogenous MCFAs and inhibitors of MCFA-CoA synthases increase the transactivation activity of the ARM repeat protein β-catenin. Taken together, our results suggest an unappreciated role for fatty acids in the regulation of proteins harboring HEAT or ARM repeats.
The impact of patient sex on intensive care unit admission: a blinded randomized survey
Authors: Zettersten Erik , Jäderling Gabriella , Larsson Emma , Bell Max 
Published: October 2019

AbstractThe gender distribution in intensive care units is consistently found to be around 60% men and 40% women. This might be medically sound. Our main purpose with this study was to investigate if physicians admit men and women to the intensive care unit equally. We sought to answer this question using a blinded randomized survey study. We used an online survey tool, with a hyperlink on European society of intensive care medicine webpage. Responders were randomized to either a critical care case Jane or a critical care case John, otherwise identical. The responders were asked if they would admit Jane/John to an intensive care unit, yes or no. Possible differences in admittance rate on the basis of the gender of the patient were analysed. In addition, we analysed if the gender of the responder affected admittance rate, regardless of the gender of the patient. 70.1% of the responders randomized to the John case opted to admit, vs. 68.3% of the responders randomized to the Jane case, p = 0.341. Regardless the gender of the patient, 70.1% of male responders opted to admit the patient, vs. 69.7% of female responders, p = 0.886. In this blinded randomized multicentre survey study, we could not demonstrate any difference in willingness to admit a patient to ICU, solely based on the gender of the patient. Patient gender as a factor for ICU admittance. A blinded randomized survey.
Lässt sich eine dauerhafte Katheterversorgung bei geriatrischen Patienten mit Harnverhalt oder chronischer Harnretention durch eine 180-W-XPS-Greenlight-Lasertherapie der Prostata vermeiden?
Authors: Knoblauch Matilda , Wiedemann Andreas , Heppner Hans-Jürgen 
Published: October 2019

Zusammenfassung
Hintergrund Geriatrische, multimorbide, immobile Patienten erhalten nach Harnverhalt oder bei signifikanter Restharnbildung häufig einen suprapubischen Katheter (SPK) auf Lebenszeit. Eine transurethrale Prostataoperation erscheint bei diesen Patienten einerseits zu risikoreich, andererseits wird die Chance auf die Restitution der Spontanmiktion als gering erachtet.
Methode Es wurde bei 48 Patienten aus dem Zeitraum von 1/2015 und 6/2016, die ursprünglich einen SPK als lebenslange Harnableitung erhalten sollten und bei denen zusätzlich eine 180-Watt-XPS™-Greenlight-Laserung vorgenommen wurde, eine retrospektive Analyse vorgenommen. Geklärt werden sollte, wie oft und wann eine spätere Entfernung des SPKs möglich war und welche Einflussfaktoren die erfolgreiche spätere Entfernung vorhersagen.
Ergebnisse Die untersuchten Patienten mit einem mittleren Alter von 75,46 Jahren hatten bei Aufnahme einen ISAR-Punktwert von 2,5 (0 – 6). Dies weist auf einen geriatrischen Handlungsbedarf hin. Die Patienten wiesen im Mittel 7,676 Diagnosen lt. Entlassungsbrief (2 – 27) und 14,85 Diagnosen (1 – 27) lt. DRG-Datensatz auf. Sie nahmen 6,77 Medikamente ein (0 – 14). Das mittlere Restharnvolumen betrug 600 (300 – 2 800) ml, das mittlere Prostatavolumen betrug 38 ccm (35 – 75 ccm). Bei 63,2 % dieser Patienten war nach einer mittleren Zeit von 52,39 Tagen (3 – 365) die Entfernung des simultan angelegten suprapubischen Katheters unter ambulanten Bedingungen möglich. Faktoren, die die erfolgreiche spätere Katheterentfernung vorhersagten, waren „geriatrische Gesichtspunkte“ wie der ISAR-Punktwert bei Aufnahme (p = 0,001), die Anzahl der Diagnosen im Entlassungsbrief (p = 0,023) und im DRG-Datensatz (p = 0,002), die Anzahl der Medikamente im Entlassungsbrief (p = 0,015), der Hilfebedarf (p = 0,001) und der Unterbringungsstatus im Heim (p = 0,008). Jede zusätzliche Medikation über den Mittelwert von 6,77 Substanzen hinaus verschlechterte die Chance auf eine erfolgreiche Katheterentfernung um 50 %).
Schlussfolgerung Bei 63,2 % der ursprünglich nur für eine suprapubische Katheteranlage vorgesehenen Patienten konnte eine simultan durchgeführte 180-Watt-XPS-Greenlight-Laserung der Prostata die lebenslange Katheteranlage vermeiden. Dies hat positive Einflüsse auf die Lebensqualität, die Vermeidung von Katheterkomplikationen und nicht zuletzt die entstehenden Kosten. Faktoren, die die erfolgreiche Katheterentfernung vorhersagen, sind entgegen der Erwartung nicht urologische Messwerte wie Restharnvolumen oder Prostatagröße, sondern geriatrische Aspekte wie der ISAR-Score, die Multimorbidität oder Multimedikation. Diese sollten in eine entsprechende Therapieentscheidung Eingang finden.
Time Trends in Prevalence of Anemia in Preschool Children in India
Authors: Kalaivani K. , Ramachandran Prema 
Published: October 2019

Abstract
Introduction Anemia is a major public health problem in Indian children. India introduced iron-folic acid supplementation for preschool children in the 1970s. In 1990, the component of detection and treatment of anemia was added. It is important to assess the impact of these programs on the prevalence of anemia in preschool children.
Materials and Methods Prevalence of anemia in preschool children at the national and state level was tabulated from National Family Health Survey (NFHS) 2, 3, and 4 national and state reports. Raw data from NFHS 2, 3, 4; District Level Household Survey (DLHS) 2 and 4; and Annual Health Survey and its Clinical Anthropometric and Biochemical component (AHS CAB) were analyzed to find out the changes in mean Hb, prevalence of anemia, and frequency distribution of Hb.
Results Compared with NFHS 2, there was a 5% increase in prevalence of anemia, 0.3 g/dL fall in mean Hb levels, and a small shift to the left in frequency distribution of Hb levels in NFHS 3. There was a 10% reduction in prevalence of anemia in NFHS 4 as compared with NFHS 3. Comparison between DLHS 2, DLHS 4, and AHS CAB showed that there was a 15 to 20% reduction in prevalence of anemia, approximately 1 g/dL increase in mean Hb and a shift to the right in distribution of Hb levels.
Conclusion There has been some improvement in Hb levels in preschool children in the last decade, but prevalence of anemia continues to be very high. Effective implementation of the comprehensive package of interventions recommended in National Iron Plus Initiative (NIPI) guidelines is urgently needed to achieve rapid and sustained reduction in anemia.
The Experiences of Medical Graduates to Peer Teaching in a Large Group
Authors: Dixit Shilpi G. , Singh Brijendra , Potaliya Pushpa , Ghatak Surajit 
Published: October 2019

AbstractMedical education is persisting to be chiefly structured around faculty authority and didactic lectures. This upholds idiosyncratic spirited milieu rather than the two-way ones desirable for the relevance in current clinical practice. The present study was set to refurbish the at hand scenario by the assimilation of active learning strategy as seminars in human anatomy curriculum of medical undergraduate program. The underlying purpose of this study was to evaluate the inclusion of varied modalities of active learning stratagem. The aim was also to construct an interactive two-way classroom prospects for thorough understanding, conceptualizing, problem solving, and utilizing student oriented presentations to elucidate multifarious subject concepts in an easy and de novo approach. The study was conducted on First Professional MBBS students in the Department of Anatomy at the Institute by a seminar activity for active comprehension followed by student feedback. A qualitative and quantitative analysis was done where close-ended questions were concerned with the usefulness of the activity and significant aspects related to the understanding of anatomy. The scores for student feedback were graded in a five-point Likert's scale. The institutional experience of facilitators of this tertiary care institution and their efforts in successful implementation of seminar activity have set an example and responsibility for the medical educators all over the globe to use more and more of such instructional approaches.
Superintegrability of the Dunkl–Coulomb problem in three-dimensions
Authors: Ghazouani Sami , Insaf Sboui 
Published: October 2019

Abstract
The superintegrability of the Dunkl–Coulomb model in three-dimensions is studied. The symmetry operators generalizing the Runge–Lenz vector operator are given. Together with the Dunkl angular momentum operators and reflection operators they generate the symmetry algebra of the Dunkl–Coulomb Hamiltonian which is a deformation of

by reflections for bound states and is a deformation of

by reflections for positive energy states. The spectrum of the Hamiltonian is derived algebraically using this symmetry algebra. The analog of the functional relation between the Coulomb Hamiltonian, Runge–Lenz operator and the angular momentum is given.
Production of methanol from biogas using methanotrophs for the application in a microbial fuel cell
Authors: Kumar Alok , Ramanathan Anand 
Published: October 2019

Abstract
Methane is available in abundance as natural and renewable gas. Methane-rich biogas has low power density so cannot be considered as a good substrate for the microbial fuel cell. The power density of methane-rich biogas can be increased by its conversion to methanol. Two-step strategy has been followed for the production of methanol from methane-rich biogas and its utilization in a microbial fuel cell. Methanol production using methanotrophs is an attractive way for the valorisation of waste-derived biogas. Besides this, methanotrophs have been used in converting the methane-rich biogas into a variety of bioproducts which include single cell protein, polyhydroxyalkanoate bioplastics, biodiesel, extracellular polysaccharides, propylene oxide, and human health supplements. This paper focusses on the biological conversion of methanol in which solid-state anaerobic digestate can be used for the isolation of methanotrophic bacterium. A fresh isolate possesses the characteristics which resembled to constrained methanotrophs from the methylocaldum genus. This freshly new isolated methanotroph evolved on purified methane or biogas and successful production of methanol is accomplished from the biogas. This study also deals with the effect of formate and various inhibitors of methanol dehydrogenase for the biological conversion of methanol and where the formate act as an electron donor. But isolate produced methanol without any electron donor with the help of phosphate. Moreover, isolate also produced methanol without methanol dehydrogenase inhibitor by the use of formate. The maximum quantity of methanol consists of an optimum quantity of formate and phosphate as a growth medium. This study reveals an efficient conversion of methanol from biogas using solid-state anaerobic digestate. The produced methanol will not go for the purification process and can be used directly in a microbial fuel cell for the power generation purpose.
Development of computer aided modelling and optimization of microwave pyrolysis of biomass by using aspen plus
Authors: Dineshkumar M , Shrikar Banagiri , Ramanathan Anand 
Published: October 2019

Abstract
Biomass energy is nowadays recognized as a potential source which constitutes the main portion of expected renewable energy supplies in the future. Biomass resources such as municipal solid waste, agricultural residue food processing industry waste, energy crops are a common type of renewable energy source and it help to produce energy, chemicals, and fuels. The useful energy recovered from biomass can be effectively utilized by a bio-energy conversion technique known as pyrolysis. Pyrolysis is considered as a kind of thermo-chemical conversion technique of waste material in the inert atmosphere to harvest biochar, syn-gas and bio fuel. Bio fuel harvest from forestry biomass through the microwave pyrolysis technology has been significantly attracting attention in the renewable energy sector over recent years. This is because of fact that microwave pyrolysis can possibly reduce greenhouse gases and contribute to energy security. A simulation model of pyrolysis process is developed by using a software called advanced system for process engineering it is basically a simulation tool for computer-aided energy modelling. This software is used to optimize and analyse the efficiency of the process involved in pyrolysis and to increase the output product yield such as bio-oil, syn-gas, and biochar with respect to the function of input parameters such as pyrolysis temperature and physio-chemical character of the biomasses. The ASPEN PLUS simulation is carried out using four different variety of biomasses namely Acacia Nilotica, Calophyllum inophyllum seed, rice husk, and Bael shell. The simulation results demonstrate that Calophyllum inophyllum seed is best suited for bio-oil production through microwave pyrolysis as it contains low moisture content and higher cellulose. The obtained bio-oil yield is up to 48% can be found from this non-edible biomass.
Numerical study of natural convection in flat receiver with and without secondary reflector for solar parabolic dish system
Authors: Natarajan Sendhil kumar , Raviteja B , Sri Harshavardhan D , Hari Prasath G , Suraparaju Subbarama Kousik 
Published: October 2019

Abstract
The sustainability of our eco system is under threat due to frequent use of the fossil fuels. Due to the rapid depletion of the conventional energy sources and oil crisis, there is a great shift towards renewable energy sources. In the realm of renewable sources of energy, solar energy plays an impeccable role because of its abundance and dominance over the other sources. Therefore, efforts are being made to replace our existing conventional fuels with renewable energy sources. In this context, flow simulation and heat transfer are performed for the flat receiver with and without secondary reflector of solar parabolic dish collector is presented. A two-dimensional (2-D) model is used to investigate the approximate estimation of the natural convection heat loss from the actual geometry of the receiver for solar dish concentrator system. The Nusselt number correlations are proposed separately and compared for both receiver with secondary reflector (WSR) and without secondary reflector (WOSR) using power law and asymptotic computational fluid dynamics technique.
Performance assessment of a sustainable Solar Air Heater (SAH) by using different profiles of absorber plates
Authors: Rajesh Singuru , Vinay Kumar Vandrasi , Sai Ram Jana 
Published: October 2019

Abstract
The main objective of solar air heater (SAH) is to make use of the solar potential for heating air and this is used for drying, crops, fishes, wet grains during post harvesting, space heating and in greenhouses. SAH is a black body which has less emissivity and high heat absorbing capacity. The air enters into the collector gets heated with addition of solar radiation. The collector is placed at an angle due to which the natural draught occurs. The main advantage of this type of air heater is compactness, maintenance, easy to assemble and dissemble. In this work a SAH is examined with the use of different materials, sizes and shapes (like plane, rugged) of absorber plates with optimum tilt angle for better thermal storage performance and greater efficiency.
Design and analysis of power convertors for electric vehicle applications
Authors: Babu Safare Sudeep , Kumar Chary S Shiva , Abdullah Syed Muhammad , Elangovan D , Thundil Karuppa Raj R 
Published: October 2019

AbstractThe surge in the cost of fuels can be accounted as a major trigger which leads to the advent of hybrid vehicles. The hybrid electric vehicles are in the reckoning to address the dangers of the exponential increase in contamination of air and global warming associated with greenhouse gases. A vehicle that is a combination of reversible storage devices like batteries and main energy sources (oil or gas) [1]. A HEV emanates reduced emission from its IC engine when compared to a pure petrol car of the same size. In the context of Hybrid Electric Vehicle, the DC-DC power converters are the electronic devices that condition the source voltage of one level to the output voltage of another level of different DC voltage based on the application provided for the electric vehicle for charging and discharging modes. The need for these power converters arises from the different voltage ratings of the hardware equipment being used. These converters acting importance due to the fact that they are efficient, easy to design and cost effective in the Hybrid electric vehicle application. The paper presents the modelling, design and simulation of buck converter the bidirectional converter based on the transmission line of powertrain of electric vehicle application. The aim is to obtain from a stable input voltage to the output voltage which is lower with high frequency and minimum ripple with specified fixed frequency in the buck operation. In bidirectional converter, the voltage stepdown is required while charging the battery while step up is needed while providing power to the motor from the battery. The design of the above-mentioned converters is performed using the standard method present in the literature. The simulation is done on PowerSim 8.0. The waveforms for the voltage and current for inductor, capacitor and the diode is also obtained. It is found that the simulation results of the voltages are in close agreement with the analytical calculations.
Research on Arc Voltage Distance-Regulating System for TIG Welding Robot
Authors: Sun Xuan , Wang Zhiyong , Li Yingjun , Ai Changsheng 
Published: October 2019

AbstractIn order to meet the demand of TIG welding robot for high precision and high real time, this paper presents the arc voltage distance-regulating system using expert controller. By precisely controlling the distance between the tungsten electrode and the welding seam, the arc voltage is precisely controlled, and the closed-loop control of arc voltage is realized. The simulation and experiment of MATLAB show that the arc voltage distance-regulating system’s arc voltage control accuracy is 18±0.8V(6±0.32mm), which meets the precision requirements of welding robot’s arc voltage control and significantly improves the welding quality.
Failure Test Optimization Method of Silicon Pressure Sensor Based on Zero Failure Data
Authors: Zuo Lei , Sun Hongkai 
Published: October 2019

Abstract
With the increasing reliability of the silicon pressure sensor, the phenomenon of zero-failure data often appears in the reliability test. This paper studies the optimal confidence limit method and distribution curve method to obtain the confidence coefficient-α and the constant-c(c>1) for the reliability analysis of zero-failure data of silicon pressure sensor, subsequently, the two methods were tested in different groups, by analyzing the influence of the number of test groups on the prediction analysis results, the optimal number of groups for the reliability prediction test of the silicon pressure sensor was obtained. The simulation results show that the best prediction results can be obtained when the confidence coefficient-α ∈ [0.3,0.6], c ∈ [4-6] and the number of groups is 10 to 13. This method improves the accuracy of failure rate estimation and reliability test efficiency with limited samples.