bluuebunny/crossref_metadata_2025_split huggingface dataset:
Optical and UV studies of type Ia supernovae SN 2009ig and SN 2012cg
Authors: Chakradhari N K , Sahu D K , Anupama G C 
Published: May 2019

Abstract
We present an extensive optical–ultraviolet photometry and analysis of a series of optical spectra of type Ia supernovae SN 2009ig and SN 2012cg. The observations range from −15 to +185 d for SN 2009ig and from −14 to 316 d for SN 2012cg, with respect to maximum light in B band. Both SN 2009ig and SN 2012cg exhibit similar properties. They have similar decline rate parameter (Δm15(B)true = 0.92 ± 0.04 for SN 2009ig and 0.93 ± 0.06 for SN 2012cg) and B band peak absolute magnitude (−19.45 ± 0.40 mag for SN 2009ig and −19.50 ± 0.31 mag for SN 2012cg). Their early spectra show high-velocity features in Si ii and Ca ii lines. The strong Fe iii, Si iii, and weak Si ii λ5972 line during pre-maximum phase are indicative of hot photosphere. The post-maximum velocity evolution shows a plateau like phase with velocities ∼13 000 km s−1 for SN 2009ig and ∼10 000 km s−1 for SN 2012cg. Both events show spectral evolution similar to normal SNe Ia and fall in LVG and Core Normal subgroup. Both have smaller strength ratio [$\cal R$(Si ii) = 0.17 for SN 2009ig and 0.20 for SN 2012cg] consistent with smaller Δm15(B). Peak bolometric luminosities ($\log L_\text{bol}^\text{max}$) of these events are estimated as 43.17 ± 0.16 and 43.24 ± 0.11 erg s−1 suggesting that 0.60 ± 0.20 M⊙ of 56Ni was synthesized in the explosion of SN 2009ig and 0.72 ± 0.31 M⊙ in SN 2012cg.
Ground-based follow-up observations of TRAPPIST-1 transits in the near-infrared
Authors: Burdanov A Y , Lederer S M , Gillon M , Delrez L , Ducrot E , de Wit J , Jehin E , Triaud A H M J , Lidman C , Spitler L , Demory B-O , Queloz D , Van Grootel V 
Published: May 2019

Abstract
The TRAPPIST-1 planetary system is a favourable target for the atmospheric characterization of temperate earth-sized exoplanets by means of transmission spectroscopy with the forthcoming James Webb Space Telescope (JWST). A possible obstacle to this technique could come from the photospheric heterogeneity of the host star that could affect planetary signatures in the transit transmission spectra. To constrain further this possibility, we gathered an extensive photometric data set of 25 TRAPPIST-1 transits observed in the near-IR J band (1.2 μm) with the UKIRT and the AAT, and in the NB2090 band (2.1 μm) with the VLT during the period 2015–18. In our analysis of these data, we used a special strategy aiming to ensure uniformity in our measurements and robustness in our conclusions. We reach a photometric precision of 0.003 (RMS of the residuals), and we detect no significant temporal variations of transit depths of TRAPPIST-1 b, c, e, and g over the period of 3 yr. The few transit depths measured for planets d and f hint towards some level of variability, but more measurements will be required for confirmation. Our depth measurements for planets b and c disagree with the stellar contamination spectra originating from the possible existence of bright spots of temperature 4500 K. We report updated transmission spectra for the six inner planets of the system which are globally flat for planets b and g and some structures are seen for planets c, d, e, and f.
YZ Phoenicis: a very short period K-type contact binary with variation of the O’Connell effect and orbital period change
Authors: Sarotsakulchai Thawicharat , Qian Sheng-Bang , Soonthornthum Boonrucksar , Zhou Xiao , Zhang Jia , Li Lin-Jia , Reichart Daniel E , Haislip Joshua B , Kouprianov Vladimir V , Poshyachinda Saran 
Published: May 2019

Abstract
YZ Phe is a very short-period contact binary (Sp. = K2 V) with an orbital period of 0.2347 d near the short period limit (0.22 d). We present the complete light curves which photometric data were obtained from the 60 cm telescope of PROMPT-8 at CTIO in Chile during 2016 June to October and 2017 August. The photometric solutions were determined by using the Wilson & Devinney code and the results reveal that YZ Phe is a W-subtype shallow contact binary ($f\sim 10\,$, q = 2.635, or 1/q = 0.379 for W subtype) with rotational motion of a large hot spot on the more massive component, showing a strong O’Connell effect with variation of maxima in photometric time series at period of 4.20 yr and stellar cycle at period of 1.28 yr. By compiling all available eclipse times, the result shows a long-term period decrease at a rate of dP/dt = −2.64(±0.02) × 10−8 d yr−1, superimposed on a cyclic variation (A3 = 0.0081 d and P3 = 40.76 yr). This variation cannot be explained by the Applegate mechanism. Thus, the cyclic change may be interpreted as the light-travel time effect via the presence of a cool third body. Based on photometric solutions, the third light was detected as $2\,$ of the total light in V and I bands. These results support the existence of a third body. The long-term period decrease can be explained by mass transfer from the more massive component ($M_2 \sim 0.74\, M_{\odot }$) to the less massive one ($M_1 \sim 0.28\, M_{\odot }$) or plus angular momentum loss (AML) via magnetic braking. With 1/q &lt; 0.4 and long-term period decrease, all factors suggest that YZ Phe is on the AML-controlled state and its fill-out factor will increase, as well as the system evolving into a deeper normal contact binary.
PD-1+CXCR5−CD4+T cells are correlated with the severity of systemic lupus erythematosus
Authors: Lin Jin , Yu Ye , Ma Jilin , Ren Chunyun , Chen Weiqian 
Published: May 2019

Abstract

Objectives
PD-1+CXCR5−CD4+T peripheral helper (Tph) cells, a recently identified T cell subset, are proven to promote B cell responses and antibody production in rheumatoid arthritis, but their role in the pathogenesis of SLE is unknown. We explored the role of Tph in lupus disease development.

Methods
This cohort study included 68 patients with SLE and 41 age- and sex-matched healthy individuals. The frequency of PD-1+CXCR5−CD4+T cells was analysed in peripheral blood by flow cytometry. Inducible T-cell costimulator, CD38, MHC-II, IL-21, CXCR3 and CCR6 expression were measured in Tph cells. Comparisons between the two groups were performed, and correlations between Tph cells and other parameters were investigated.

Results
We revealed a markedly expanded population of Tph cells (8.31 ± 5.45 vs 2.86 ± 1.31%, P < 0.0001) in the circulation of patients with SLE (n = 68), compared with healthy controls (n = 41). Tph cells were much higher in the active group than in the inactive group (14.21 ± 5.21 vs 5.49 ± 2.52%, P < 0.0001). Tph cells were significantly associated with SLEDAI score (r = 0.802), ESR (r = 0.415), IgG (r = 0.434), C3 (r = −0.543), C4 (r = −0.518) and IL-21 level (r = 0.628), and ANA titre (r = 0.272). Furthermore, Tph cells were much higher in lupus patients with arthritis, nephritis, rash, alopecia, pleuritis, pericarditis and haematological involvement. Tph cells were associated with CD138+/CD19+ plasma cells (r = 0.518). Furthermore, MHC-II, inducible T-cell costimulator, CD38, and IL-21 expression were all higher in Tph cells from SLE patients compared with healthy controls. CXCR3+CCR6−Tph (Tph1) cells were expanded in the SLE patients.

Conclusion
Our data show that relative number of Tph cells is correlated with disease measures in patients with SLE, suggesting an important role in lupus disease development.
Interactions of Dichlorodiphenyltrichloroethane (DDT) and Dichlorodiphenyldichloroethylene (DDE) With Skeletal Muscle Ryanodine Receptor Type 1
Authors: Truong Kim M , Cherednichenko Gennady , Pessah Isaac N 
Published: May 2019

Abstract
Dichlorodiphenyltrichloroethane (DDT) and its metabolite dichlorodiphenyldichloroethylene (DDE) are ubiquitous in the environment and detected in tissues of living organisms. Although DDT owes its insecticidal activity to impeding closure of voltage-gated sodium channels, it mediates toxicity in mammals by acting as an endocrine disruptor (ED). Numerous studies demonstrate DDT/DDE to be EDs, but studies examining muscle-specific effects mediated by nonhormonal receptors in mammals are lacking. Therefore, we investigated whether o,p′-DDT, p,p′-DDT, o,p′-DDE, and p,p′-DDE (DDx, collectively) alter the function of ryanodine receptor type 1 (RyR1), a protein critical for skeletal muscle excitation-contraction coupling and muscle health. DDx (0.01–10 µM) elicited concentration-dependent increases in [3H]ryanodine ([3H]Ry) binding to RyR1 with o,p′-DDE showing highest potency and efficacy. DDx also showed sex differences in [3H]Ry-binding efficacy toward RyR1, where [3H]Ry-binding in female muscle preparations was greater than male counterparts. Measurements of Ca2+ transport across sarcoplasmic reticulum (SR) membrane vesicles further confirmed DDx can selectively engage with RyR1 to cause Ca2+ efflux from SR stores. DDx also disrupts RyR1-signaling in HEK293T cells stably expressing RyR1 (HEK-RyR1). Pretreatment with DDx (0.1–10 µM) for 100 s, 12 h, or 24 h significantly sensitized Ca2+-efflux triggered by RyR agonist caffeine in a concentration-dependent manner. o,p′-DDE (24 h; 1 µM) significantly increased Ca2+-transient amplitude from electrically stimulated mouse myotubes compared with control and displayed abnormal fatigability. In conclusion, our study demonstrates DDx can directly interact and modulate RyR1 conformation, thereby altering SR Ca2+-dynamics and sensitize RyR1-expressing cells to RyR1 activators, which may ultimately contribute to long-term impairments in muscle health.
Prenatal Exposure to Bisphenol A, E, and S Induces Transgenerational Effects on Female Reproductive Functions in Mice
Authors: Shi Mingxin , Whorton Allison E , Sekulovski Nikola , MacLean James A , Hayashi Kanako 
Published: May 2019

Abstract
This study was performed to examine the transgenerational effects of bisphenol (BP) A analogs, BPE, and BPS on female reproductive functions using mice as a model. CD-1 mice (F0) were orally exposed to control treatment (corn oil), BPA, BPE, or BPS (0.5 or 50 µg/kg/day) from gestational day 7 (the presence of vaginal plug = 1) to birth. Mice from F1 and F2 offspring were used to generate F3 females. Prenatal exposure to BPA, BPE, and BPS accelerated the onset of puberty and exhibited abnormal estrous cyclicity in F3 females, and those females exhibited mating difficulties starting at 6 months of age. Various fertility problems including reduced pregnancy rates, parturition, and nursing issues were also observed starting at 6 months, which worsened at 9 months. The levels of serum estradiol-17β were elevated by BPA or BPS exposure at the age of 6 months, whereas testosterone levels were not affected. The dysregulated expression of steroidogenic enzymes was observed in the ovary at 3 or 6 months of age by BPE or BPS exposure. However, BPA, BPE, and BPS exposure did not affect neonatal follicular development such as germ cell nest breakdown or follicle numbers in the ovary on postnatal day 4. These results suggest that prenatal exposure to BPA analogs, BPE and BPS, have transgenerational effects on female reproductive functions in mice.
Management trends for postcatheterization femoral artery pseudoaneurysms
Authors: Madia Carol 
Published: May 2019

ABSTRACT
Femoral artery pseudoaneurysm is the most common complication of femoral artery access. Since the 1990s, use of femoral artery access has increased along with cardiac and peripheral interventions. Conservative management with observation is an option for some patients with femoral artery pseudoaneurysms. Open surgical repair was the mainstay of therapy before 1990 but was replaced by ultrasound-guided compression, which in turn has been replaced by ultrasound-guided thrombin injection because of its high success rate and low rate of complications. This article describes femoral artery pseudoaneurysms and their management.
How to recognize caffeine overdose
Authors: Carreon Christian “CJ” , Parsh Bridget 
Published: May 2019

Abstract:
Caffeine is the most widely consumed stimulant in the world and can offer a variety of benefits when consumed in moderation. But consuming caffeine in extremely high amounts can lead to an overdose. This article examines how nurses can recognize the signs and symptoms of caffeine overdose and educate patients on how to prevent this common problem.
Positive End-expiratory Pressure and Postoperative Atelectasis
Authors: Östberg Erland , Thorisson Arnar , Enlund Mats , Zetterström Henrik , Hedenstierna Göran , Edmark Lennart 
Published: May 2019

Abstract

Editor’s Perspective

What We Already Know about This Topic

What This Article Tells Us That Is New

Background
Positive end-expiratory pressure (PEEP) increases lung volume and protects against alveolar collapse during anesthesia. During emergence, safety preoxygenation preparatory to extubation makes the lung susceptible to gas absorption and alveolar collapse, especially in dependent regions being kept open by PEEP. We hypothesized that withdrawing PEEP before starting emergence preoxygenation would limit postoperative atelectasis formation.

Methods
This was a randomized controlled evaluator-blinded trial in 30 healthy patients undergoing nonabdominal surgery under general anesthesia and mechanical ventilation with PEEP 7 or 9 cm H2O depending on body mass index. A computed tomography scan at the end of surgery assessed baseline atelectasis. The study subjects were thereafter allocated to either maintained PEEP (n = 16) or zero PEEP (n = 14) during emergence preoxygenation. The primary outcome was change in atelectasis area as evaluated by a second computed tomography scan 30 min after extubation. Oxygenation was assessed by arterial blood gases.

Results
Baseline atelectasis was small and increased modestly during awakening, with no statistically significant difference between groups. With PEEP applied during awakening, the increase in atelectasis area was median (range) 1.6 (−1.1 to 12.3) cm2 and without PEEP 2.3 (−1.6 to 7.8) cm2. The difference was 0.7 cm2 (95% CI, −0.8 to 2.9 cm2; P = 0.400). Postoperative atelectasis for all patients was median 5.2 cm2 (95% CI, 4.3 to 5.7 cm2), corresponding to median 2.5% of the total lung area (95% CI, 2.0 to 3.0%). Postoperative oxygenation was unchanged in both groups when compared to oxygenation in the preoperative awake state.

Conclusions
Withdrawing PEEP before emergence preoxygenation does not reduce atelectasis formation after nonabdominal surgery. Despite using 100% oxygen during awakening, postoperative atelectasis is small and does not affect oxygenation, possibly conditional on an open lung during anesthesia, as achieved by intraoperative PEEP.
Risk Factors for Postoperative Distal Adding-on in Lenke Type 1B and 1C and its Influence on Residual Lumbar Curve
Authors: Fujii Takeshi , Daimon Kenshi , Fujita Nobuyuki , Yagi Mitsuru , Michikawa Takehiro , Hosogane Naobumi , Nagoshi Narihito , Tsuji Osahiko , Kaneko Shinjiro , Tsuji Takashi , Nakamura Masaya , Matsumoto Morio , Watanabe Kota 
Published: May 2019

Background:
Distal adding-on (DA) in adolescent idiopathic scoliosis is a radiographic complication that can negatively affect clinical results. However, the risk factors for DA and the influences of DA on the residual lumbar curves have not been fully elucidated in Lenke type 1B and 1C curves. The objective of this study was to investigate risk factors for postoperative DA in Lenke type 1B and 1C curves, and the influence of DA on residual lumbar curves.

Methods:
We retrospectively evaluated 46 adolescent idiopathic scoliosis patients with Lenke type 1B or 1C curves who underwent posterior correction and fusion surgery with selective thoracic fusion. Patients were grouped according to the presence or absence of DA on radiographs at the 2-year follow-up. We compared coronal radiographic parameters between the 2 groups, including the Cobb angle, L4 tilt angle, apical translation, and relative positions of the end vertebra (EV), stable vertebra (SV), neutral vertebra (NV), and last touching vertebra (LTV) to the lower instrumented vertebra (LIV).

Results:
DA was present in 11 patients (24%) at the 2-year follow-up, and the mean LIV-EV, LIV-NV, LIV-SV, and LIV-LTV relative positions were significantly smaller in the DA than in the non-DA group. Preoperative radiographic parameters were similar between the 2 groups, including the mean L4 tilt angle (non-DA, −8±4 degrees; DA, −7±4 degrees). At the 2-year follow-up, the mean apical translation of the lumbar curve was smaller in the DA group (non-DA, −16±8 mm; DA, −7±11 mm) and the mean L4 tilt angle was significantly more horizontalized (non-DA, −8±4 degrees; DA, −1±5 degrees). Multivariate analysis showed that the number of levels between the LIV and LTV (LIV-LTV) was significantly associated with DA.

Conclusions:
A LIV at or cranial to the LTV was a significant risk factor for postoperative DA in Lenke type 1B and 1C curves. Spontaneous correction of the residual lumbar curve was superior in patients with DA.

Level of Evidence:
Level III.
Repair of Pars Interarticularis Defect Utilizing a Pedicle and Laminar Screw Construct: A Technique Discussion and Case Series
Authors: Snowden Ryan , Sasso Rick 
Published: May 2019

Introduction:
Lumbar isthmic spondylolysis is a common disorder in young adults and adolescents. Following failure of nonoperative measures, multiple nonfusion techniques have been described to repair the spondylotic defect with varying results. Recently a new pedicle screw-laminar screw construct has been described and found comparable to other pedicle screw constructs in biomechanical testing. We describe the use of the pedicle screw-lamina screw constructs using image guidance and 3-dimensional imaging in the surgical management of isthmic spondylolysis. We also present a case series of patients undergoing treatment of isthmic spondylolysis. All patients undergoing pedicle screw-laminar screw pars repair construct from 2012 to 2017 by the senior author.

Materials and Methods:
All patients undergoing pedicle screw-laminar screw pars repair by the senior author from 2012 to 2017 were included. Patients were excluded for spondylolisthesis, disc degeneration at the level of spondylolysis, advanced age (>25), evidence of nerve root compression or significant signs of degenerative osteoarthritis. All patients failed a standardized course of nonoperative treatment before surgery. Patients were followed until full, pain-free activity had resumed. Six patients successfully underwent pedicle screw-laminar screw pars repair using intraoperative computed tomography guidance. There were no intraoperative or postoperative complications. All patients returned to full athletic activity at an average of 5.17 months. Final radiographs showed complete or near complete resolution of the defect in all cases. We are the first to describe the use of the pedicle screw-lamina screw constructs using image guidance and 3-dimensional imaging in the surgical management of isthmic spondylolisthesis in a clinical situation. The combination of pedicle screw and laminar screw provides a construct with robust fixation while allowing for ample bone grafting surface area. Furthermore, the utilization of intraoperative navigations provides an added measure of safety when placing both screws.
Case Study: Periumbilical Pain in a 14-Year-Old Male
Authors: Donahue Hannah , Koonce Robin 
Published: May 2019

Abstract
This is a “Name the Diagnosis” for a 14-year-old male adolescent who presented with periumbilical pain. On ultrasound, he was noted to have intussusception. Because of his age, further imaging was performed to determine the lead point for his intussusception. During surgery, he was found to have a Meckel's diverticulum, which was acting as the lead point.
Is the evidence strong enough for acupuncture ameliorates clinical symptoms in patients with amyotrophic lateral sclerosis
Authors: Liao Qun , Li Zunjiang , Zeng Hai , Feng Xiaocong , Huang Wei , Fu Chuying , Liang Xiaolin , Li Tian 
Published: May 2019

Abstract

Background:
Amyotrophic lateral sclerosis (ALS) is the most common form of motor neuron diseases. Until now, it lacks effective drugs for its treatment, and the median survival time of ALS is reported as only 20 to 48 months after the onset of symptoms. Acupuncture served as part of traditional Chinese therapy, has been widely applied to clinical practice for patients with ALS but lacks studies to verify its efficacy. This study provides a protocol of systematic review, with which we will comprehensively verify the effects of acupuncture on ALS with evidence-based studies.

Methods:
The eligible studies will be collected from 4 English databases (the MEDLINE via PubMed, the Cochrane Library, EMBASE, the Web of Science, and Ovid database), and 4 Chinese databases (China Science and Technology Journal Database, Chinese Biomedical Literature Database, Wan-fang Database, China National Knowledge Infrastructure) from October 2000 to October 2022. The primary outcome measure is the change in amyotrophic lateral sclerosis functional rating scale-revised (ALSFRS-R) scores. We will use RevMan V.5.3 software to calculate the data synthesis and will conduct meta-analysis based on the collected data.

Results:
The primary outcome measure is the change in ALSFRS-R scores, and secondary outcome measures included changes in forced vital capacity, grasping power, pinch strength, modified Norris Scale, ALS assessment questionnaire-40, and time to activity of daily living-independent will be measured and comprehensively assessed to evaluate the effect of acupuncture on ALS from this systematic review and meta-analysis.

Conclusion:
The systematic review and meta-analysis will assess the effect of acupuncture in the treatment of ALS with up-to-date clinical evidence.

PROSPERO registration number:
PROSPERO CRD 42019124785.
Long non-coding RNA antisense non-coding RNA in the INK4 locus expression correlates with increased disease risk, severity, and inflammation of allergic rhinitis
Authors: Qian Xiaoqiong , Shi Song , Zhang Guijuan 
Published: May 2019

Abstract
The aim of the current study was to investigate the expression of long non-coding RNA (lncRNA) antisense non-coding RNA in the INK4 locus (ANRIL) in allergic rhinitis (AR) patients, and to further explore the association of lncRNA ANRIL expression with AR risk, severity, and inflammation.
In this case-control study, 96 AR patients and 96 non-atopic obstructive snoring patients who underwent adenoid surgery were consecutively recruited. Disease severity of AR patients was assessed via individual nasal symptom score (INSS) and total nasal symptom score (TNSS). Nasal mucosa samples were collected from AR patients and controls, then lncRNA ANRIL and inflammatory cytokine levels were assessed via quantitative polymerase chain reaction.
LncRNA ANRIL expression was increased in AR patients (3.605 [1.763–4.981]) compared with controls (1.183 [0.438–2.985]), and it well distinguished AR patients from controls with an area under curve of 0.746 (95% CI: 0.679–0.814). Correlation analyses revealed that lncRNA ANRIL expression was positively associated with itching score and congestion score, while it was not associated with nasal rhinorrhea score or sneezing score. Besides, lncRNA ANRIL was also positively correlated with TNSS, tumor necrosis factor α, interleukin (IL)-4, IL-6, IL-13, and IL-17, while negatively associated with IL-10 and interferon-γ. And no association of lncRNA ANRIL expression with IL-1β, IL-5, or IL-8 expression was discovered.
LncRNA ANRIL expression correlates with increased AR risk, severity, and inflammation, implying that lncRNA ANRIL might be involved in the pathogenesis of AR.