bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Increase in Nutritional Status by Fermented Milk Supplement on Elementary School Children from Fisherman's Village in Bantul, Yogyakarta Province of Indonesia
Authors: Kesetyaningsih Tri Wulandari , Orbayinah Salmah , Suryani Lilis 
Published: August 2018

Abstract: Probiotics drinks, containing Lactobacillus, were rapidly developed because of its benefit to the health. The bacteria reduced the pathogenic microorganism growth such as virus, fungi, and protozoa. The nutritional status is influenced by food intake, immunity and infection. The children of fisherman’s village are included in the insecure nutrition group because of the low social economic status and healthy living behavior. The aim of this research was to know the influence of daily consumption of probiotics in fermented milk to the nutrition status in elementary school children. This research is quasi-experimental with pretest-posttest control group design. Subjects of 95 elementary school children were divided into 2 groups: 62 children as treatment group and 33 children as control group. Determination of nutritional status is based on anthropometry according to CDC 2000 (BMI-age) growth-chart; and the biochemistry parameter consist of the level of serum total protein, albumin, blood urea nitrogen (BUN), urine creatinine and hemoglobin. Determination of serum total protein and BUN were carried out by Microkjeldahl method, hemoglobine by cyanmet hemoglobin method, albumin by dye-binding method, and creatinine level by Jaffe reaction method. The infection status was determined by anamnesis and laboratory examination of feces which was conducted to find the parasite in the stool. Of sixty five ml fermented milk, that contains of 6.5 x 109 Lactobacillus shirota strain, was consumed every day in 37 days. The data was analyzed by Wilcoxon test for nonparametric data and paired T-test for parametric data. The result shows that after the treatment, it increased the nutritional status athropometrically from underweight to normal (12.9%) and overweight to normal (3.23%). In biochemically, it increased the total protein level from 6,111 to 6,705 mg/dL (p=0,001) and decreased the BUN from 42,709 to 41,127 mg/dL (p=0,004) significantly eventhough it was in normal range. The conclusion is that consuming fermented milk for 37 days in children is proven to enhance the nutritional status both by anthropometric and biochemistry parameter. Keywords: probiotic, nutritional status, Lactobacillus, fermented milk supplement
The Relationship of Infectious Diseases History and Mother Factors to Under Red Line Among Toddler
Authors: Musafaah Musafaah , Fajriannor Muhammad 
Published: August 2018

Abstract: Nutrition under the red line is a state of severe nutritional deficiency caused by low consumption of energy and protein from daily food. Sungai Tiung is the village that has the highest number of children under five with under red line (BGM) from other villages in the working area of Rawat Inap Cempaka Health Center. This study aims to know the relationship of infectious diseases history and mother factors to under red line (BGM) among toddler in Sungai Tiung. This research uses cross-sectional design. The samples are 90 respondents. Sampling used purposive sampling. The independent variables are a history of infectious disease, knowledge, education, and mother care pattern. The dependent variable is under red line (BGM). The instrument in this study used questionaire and Kartu Menuju Sehat (KMS). The result showed that there is a relationship history of infectious diseases with BGM (p-value = 0.03). The results also showed no relationship of knowledge (p-value = 0.12), education (p-value = 0.75) and mother care pattern (p-value = 0.32) with BGM. There is a relationship history of infectious diseases with BGM. So that, there should be efforts to prevent infectious diseases in toddler. Keywords : under red line, toddler, infectious diseases
Effect of Anti-Tuberculosis Multi Drug Resistance Regimen on Hematological Lung Tuberculosis Patients Profile with Multi Drug Resistance
Authors: Putra Pradana Maulana 
Published: August 2018

Abstract: ATD administration of tuberculosis in combination and duration often causes multi drug resistance (MDR) ATD due to discontinuation of treatment. Reported hematologic abnormal changes due to ATD. This study investigated hematological changes before and during MDR therapy of MDR TB patients in Tuberculosis MDR RSUD Ulin Banjarmasin from September to December 2017. The study population was patients treated in TB MDR Poly and selected samples with a time-limiting method. Inclusion and exclusion criteria were MDR-TB patients detected by Gene Xpert® examination, treated <30 days, between 18 and 65 years of age, HIV negative, as well as identification and laboratory data recorded in the complete medical record. 17 samples collected by hematological parameters were collected. There were significant changes in hemoglobin, hematocrit, platelets, RDW-CV, MCV, eosinophils, lymphocytes, granulocytes, and monocytes after treatment. It was concluded that MDR regimen ATD did not cause anemia and thrombocytopenia. There was also no significant change in WBC even though the count of the species changed significantly Keywords: Tubeculosis, Multi Drug Resistency (MDR), Anti Tuberculosis Drugs (ATD), profil hematologis
Peroneal Nerve Function and Knee Stability after Resection Giant Cell Tumour of Proximal Fibula, A Serial Case
Authors: Mustaqim Warih Anggoro , Isma Satria Pandu Persada , Irsan Istan Irmansyah 
Published: August 2018

Abstract: Giant-cell Tumour (GCT ) is a benign Tumour, locally aggressive neoplasm which is composed of sheets of neoplastic oviod mononuclear cells uniformly distributed large, osteoclast like giant cell. Incidence GCT of proximal fibula is rare. Peroneal nerve function and stability of knee joint must be considered at the proximal fibula GCT. In 2017 we found three cases of GCT of the proximal fibula in the outpatient clinic Saiful Anwar General Hospital. All three of these patients had a confirmed GCT of proximal fibula which planned for Tumour resection, peroneal nerve presevation and LCL ligament reconstruction. This is study of three patients with GCT of proximal fibula was confirm with Clinical Pathological Confrence (CPC). All of patient had presented of lump, slowly growing pain in lateral side of knee, limping when they walk and numbness in dorsal side of foot. One patient cannot dorsoflexion of ankle. We evaluated a peroneal nerve function and stability of knee after operation and one year after resection of tumour. All patient had occurred peroneal nerve lesion with no instability of knee post operatively. Two patient had complaint with numbness in dorsal side of foot and weakness ankle dorsoflexion and after one year both of patient had improved ankle dorsoflexion but still numbness in dorsal side of foot. One patient still complaining numbness in dorsal side of foot and weakness ankle dorsoflexion post operation and one year after operation. There is no LCL ligament instability in all of patient post operation and one year after operation. The peroneal nerve function and LCL ligament stability must consider when facing benign tumours in proximal fibula such as giant cell tumour proximal fibula. These resections result in an unavoidable loss of knee stability because of resecting the lateral collateral ligament (LCL) insertion site on the fibular head. Based on the literature, the incidence rate of postoperative peroneal nerve palsy ranges from 3% to 57%. Giant cell tumour in proximal fibula is rare and require wide excision with intraarticular resection of the proximal tibioﬁbular join. We must consider about peroneal nerve function and LCL ligament stability during resection of GCT proximal fibula. Keywords: Giant Cell Tumour Proximal Fibula, Peroneal Nerve function, LCL Ligament stability
Real-Time Whole-Body Imitation by Humanoid Robots and Task-Oriented Teleoperation Using an Analytical Mapping Method and Quantitative Evaluation
Authors: Zhang Zhijun , Niu Yaru , Yan Ziyi , Lin Shuyang 
Published: August 2018

Due to the limitations on the capabilities of current robots regarding task learning and performance,
imitation is an efficient social learning approach that endows a robot with the ability to transmit and reproduce human postures, actions, behaviors, etc., as a human does.
Stable whole-body imitation and task-oriented teleoperation via imitation are challenging issues.
In this paper, a novel comprehensive and unrestricted real-time whole-body imitation system for humanoid robots is designed and developed. To map human motions to a robot, an analytical method called geometrical analysis based on link vectors and virtual joints (GA-LVVJ) is proposed. In addition, a real-time locomotion method is employed to realize a natural mode of operation. To achieve safe mode switching, a filter strategy is proposed. Then, two quantitative vector-set-based methods of similarity evaluation focusing on the whole body and local links, called the Whole-Body-Focused (WBF) method and the Local-Link-Focused (LLF) method, respectively, are proposed and compared. Two experiments conducted to verify the effectiveness of the proposed methods and system are reported. Specifically, the first experiment validates the good stability and similarity features of our system, and the second experiment verifies the effectiveness with which complicated tasks can be executed. At last, an imitation learning mechanism in which the joint angles of demonstrators are mapped by GA-LVVJ is presented and developed to extend the proposed system.
Insights into the Drug Repositioning Applied to the Alzheimer's Disease Treatment and Future Perspectives
Authors: de Castro Alexandre A. , da Cunha Elaine F.F. , Pereira Ander F. , Soares Flavia V. , Leal Daniel H.S. , Kuca Kamil , Ramalho Teodorico C. 
Published: August 2018

Introduction:
Alzheimer's disease is known to be a chronic disease, with an estimated prevalence
of about 10-30%, considering the population over 60 years of age. Most patients with this disorder
(> 95%) present the sporadic form, being characterized by a late onset (80-90 years of age), and it is the
consequence of the failure to clear the amyloid-β (Aβ) peptide from the interstices of the brain. Significant
numbers of genetic risk factors for the sporadic disease have been researched. Some existing drugs
for Alzheimer's disease provide symptomatic benefit for up to 12 months, but there are no approved disease-
modifying therapies. In this line, a complementary strategy based on repositioning drugs which are
approved for the treatment of other disorders could be interesting. It is noteworthy the fact that some
clinical trials indicate that several classes of drugs own potent and beneficial effects on the Alzheimer's
disease treatment. In this present work, we present the details and evaluation of these alternative treatments.
It has highlighted several compounds with relevant evidence for this purpose, which deserves
further investigation to clarify optimal treatment conditions in the clinical trials of patients with Alzheimer's
disease.
Dabigatran Reversal with Idarucizumab in an Emergency Lumbar Puncture: A Case Report
Authors: Spagnolello Ornella , Letteri Federica , Falcou Anne , Cipollone Lorena , De Michele Manuela , Bertazzoni Giuliano , Toni Danilo 
Published: August 2018

Introduction:
The widespread use of direct oral anticoagulants (DOACs) has been
increasing the conditions in which emergency physicians are forced to rapidly reverse anticoagulation
in case of life-threatening bleeding or need of urgent surgery or invasive procedures.

The recent approval of Idarucizumab, a humanized monoclonal antibody fragment (Fab), offered the
opportunity to rapidly and safely neutralize the anticoagulant effect of Dabigatran. However, real-world
experience of its effective use in different emergency setting is now required. Lumbar Puncture (LP) is
recognized as an invasive procedure at major bleeding risk and is, therefore, contraindicated in anticoagulated
patients.

Conclusion:
We report a successful use of Idarucizumab in an emergency LP of a young woman with a
possible diagnosis of encephalitis and a previous history of venous thromboembolism on long-term
treatment with Dabigatran 150 mg twice a day.
Prevention of Infection in Adults Receiving Intravenous Antibiotic Treatment via Indwelling Central Venous Access Devices
Authors: Puri Basant K. , Derham Anne , Monro Jean A. 
Published: August 2018

Background:
The use of indwelling Central Venous Access Devices (CVADs) is associated
with the development of bloodstream infections. When CVADs are used to administer systemic
antibiotics, particularly second- or higher-generation cephalosporins, there is a particular risk of developing
Clostridium difficile infection. The overall bloodstream infection rate is estimated to be
around 1.74 per 1000 Central Venous Catheter (CVC)-days.

Objective:
We hypothesised that daily oral administration of the anion-binding resin colestyramine
(cholestyramine) would help prevent infections in those receiving intravenous antibiotic treatment via
CVADs.

Method:
A small case series is described of adult patients who received regular intravenous antibiotic
treatment (ceftriaxone, daptomycin or vancomycin) for up to 40 weeks via indwelling CVADs; this
represented a total of 357 CVC-days. In addition to following well-established strategies to prevent C.
difficile infection, during the course of the intravenous antibiotic treatment the patients also received
daily oral supplementation with 4 g colestyramine.

Results:
There were no untoward infectious events. In particular, none of the patients developed any
symptoms or signs of C. difficile infection, whereas approximately one case of a bloodstream infection
would have been expected.

Conclusion:
It is suggested that oral colestyramine supplementation may help prevent such infection
through its ability to bind C. difficile toxin A (TcdA) and C. difficile toxin B (TcdB); these toxins are
able to gain entry into host cells through receptor-mediated endocytosis, while anti-toxin antibody
responses to TcdA and TcdB have been shown to induce protection against C. difficile infection
sequelae.
Novel Tetrahydrobenzo [b] Thiophene Compounds Exhibit Anticancer Activity through Enhancing Apoptosis and Inhibiting Tyrosine Kinase
Authors: El-Metwally Souad A. , Khalil Ali K. , El-Naggar Abeer M. , El-Sayed Wael M. 
Published: August 2018

Background:
Developing new chemotherapeutic agents with molecular targets, larger margin of
safety against normal cells and low cost is the target many scientists try to achieve.

Objective:
The present study was undertaken to investigate the anticancer activity of a novel series of thiophene
compounds and the molecular mechanisms associated.

Method:
A series of novel heterocyclic compounds including pyrimidine derivatives (2, 3, 4, 5 8, 11, 12, 13, 14,
and 15), thiophene derivatives (6, 7, and 10) and oxoisothiazolidine derivative (9) was synthesized from 4,5,6,7-
tetrahydrobenzo[b] thiophene (1). The newly synthesized derivatives along with the parent compound were
evaluated for their anticancer activity against human HepG2, MCF7 and HCT116 cell lines and compared to
doxorubicin as a reference drug.

Results:
Compound 7 was very selective in targeting only the colon cells. Compounds 1, 5, and 12 showed
strong cytotoxic activities against the 3 cell lines at 6-16 µM without any apparent toxicity to the normal fibroblasts
WI-38. They had DNA affinity at 29-36 µM. The three compounds enhanced apoptosis to varying degrees
elevating the expression of Bax, caspase 9 and caspase 3 in HepG2. Compound 5 was the most potent analogue
and was superior to the standard drug used in upregulating the apoptotic genes and inhibiting tyrosine kinase at
1 µM. The IC50 value for compound 5 against TK was 296 nM.

Conclusion:
Taken together, this study presents some thiophene scaffolds as auspicious hits for further optimization
as specific antiproliferative agents against cancer cells and promising tyrosine kinase inhibitors at nanomolar
concentrations.
Effects of Exercise and Ferulic Acid on Alpha Synuclein and Neuroprotective Heat Shock Protein 70 in An Experimental Model of Parkinsonism Disease
Authors: Askar Mona H. , Hussein Abdelaziz M. , Al-Basiony Soheir F. , Meseha Refka K. , Metias Emile F. , Salama Mohamed M. , Antar Ashraf , El-Sayed Aya 
Published: August 2018

Background & Objective: This study investigated the effects of ferulic acid (FR), muscle exercise (Ex) and combination of them on rotenone (Rot)-induced Parkinson disease (PD) in mice as well as their underlying mechanisms. </P><P> Method: 56 male C57BL/6 mice were allocated into 8 equal groups, 1) Normal control (CTL), 2) FR (mice received FR at 20 mg/kg/day), 3) Ex (mice received swimming Ex) and 4) Ex + FR (mice received FR and Ex), 5) Rot (mice received Rot 3 mg/Kg i.p. for 70 days), 6) ROT+ FR (mice received Rot + FR at 20 mg/kg/day), 7) ROT+ Ex (mice received Rot + swimming Ex) and 8) ROT+ Ex + FR (mice received Rot + FR and Ex). ROT group showed significant impairment in motor performance and significant reduction in tyrosine hydroxylase (TH) density and Hsp70 expression (p< 0.05) with Lewy bodies (alpha synuclein) aggregates in corpus striatum. Also, ROT+FR, ROT+EX and ROT + Ex+ FR groups showed significant improvement in behavioral and biochemical changes, however the effect of FR alone was more potent than Ex alone (p< 0.05) and addition of Ex to FR caused no more significant improvement than FR alone.Conclusion:We concluded that, FR and Ex improved the motor performance in rotenone-induced PD rodent model which might be due to increased Hsp70 expression and TH density in corpus striatum and combination of both did not offer more protection than FR alone.
Autophagy and Mitochondria: Targets in Neurodegenerative Disorders
Authors: Kumar Ashutosh , Dhawan Amruta , Kadam Alknanda , Shinde Akshada 
Published: August 2018

Background & Objective: Cellular physiology and energy metabolism are maintained by
the constant supply of energy furnished by the powerhouses of the cell called mitochondria. Cellular
homeostasis depends on the timely clearance of damaged cellular organelles and proteins via pathways
including autophagy. Mitochondria and mitochondrial autophagy play a vital role in cellular health and
failure of these pathways can have a devastating effect on cellular homeostasis. Amongst the various cell
types, neuronal cells are more vulnerable to bioenergetic depletion since most of their functions critically
depend on the availability of energy derived from mitochondrial metabolism, thus making neurodegenerative
disorders an obstinate issue. Research in the past few decades has shown that these neurodegenerative
disorders are associated with mitochondrial dysfunction and compromised mitophagy leading to
accumulation of protein aggregates which ultimately culminate in neurodegeneration.

Conclusion:
Thus, targeting mitochondria and autophagy-related proteins and enzymes in neurodegenerative
disorders may open the avenues for potential targets for discovering effective therapies.
Here, we review the involvement of mitochondrial and autophagy dysfunction in neurodegenerative
disorders specifically focusing on Alzheimer’s, Parkinson’s and Huntington’s disease.
F.E.M. Stress-Investigation of Scolios Apex
Authors: Daghighi A. , Tropp H. , Dahlström N. , Klarbring A. 
Published: August 2018

Background:In scoliosis, kypholordos and wedge properties of the vertebrae should be involved in determining how stress is distributed in the vertebral column. The impact is logically expected to be maximal at the apex.Aim:To introduce an algorithm for constructing artificial geometric models of the vertebral column from DICOM stacks, with the ultimate aim to obtain a formalized way to create simplistic models, which enhance and focus on wedge properties and relative tilting.Material/Methods:Our procedure requires parameter extraction from DICOM image-stacks (with PACS,IDS-7), mechanical FEM-modelling (with Matlab and Comsol). As a test implementation, models were constructed for five patients with thoracal idiopathic scoliosis with varying apex rotation. For a selection of load states, we calculated a response variable which is based upon distortion energy.Results:For the test implementation, pairwise t-tests show that our response variable is non-trivial and that it is chiefly sensitive to the transversal stresses (transversal stresses where of main interest to us, as opposed to the case of additional shear stresses, due to the lack of explicit surrounding tissue and ligaments in our model). Also, a pairwise t-test did not show a difference (n = 25, p-value≈0.084) between the cases of isotropic and orthotropic material modeling.Conclusion:A step-by-step description is given for a procedure of constructing artificial geometric models from chest CT DICOM-stacks, such that the models are appropriate for semi-global stress-analysis, where the focus is on the wedge properties and relative tilting. The method is inappropriate for analyses where the local roughness and irregularities of surfaces are wanted features. A test application hints that one particular load state possibly has a high correlation to a certain response variable (based upon distortion energy distribution on a surface of the apex), however, the number of patients is too small to draw any statistical conclusions.
Minimum Delay Congestion Control in Differentiated Service Communication Networks
Authors: Khodhair Saadi Alobaidi , Naghmash Majid S. , Abduljabbar Riyadh Bassil , Ahmed ALRawi Ali Amer 
Published: August 2018

Introduction:This paper presents a minimum delay congestion control in differentiated Service communication networks. The premium and ordinary passage services based fluid flow theory is used to build the suggested structure in high efficient manage. The established system is capable to adeptly manage both the physical network resource limitations and indefinite time delay related to networking system structure.Methods:The effectiveness of the suggested congestion controller system is demonstrated with mathematical consequences in formal framework by using modified sliding controller (MSMC) techniques. This technique provides high utilization and less delay after adapting the state feedbacks controllers with sliding mode controller. The Quality of Service (QoS) requirements in term of effective and dynamic regulation of network resources have been achieved in the existing design.Results:The capacity and bandwidth limitations are considered as a restriction on the input of network. The results of this approach are developed and compared with a conventional design.