bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparison between blood and non-blood cardioplegia in tetralogy of Fallot
Authors: Romolo Harvey , Hernisa Latifa , Fakhri Dicky , Rachmat Jusuf , Dwi Mulia Dina , Rahmat Budi 
Published: December 2018

Background Cardioplegia is an integral part of myocardial protection. The superiority of blood cardioplegia in adult patients has been reported. However, this is yet to be studied in cyanotic pediatric patients. Methods A randomized open-label trial was conducted in 70 patients with tetralogy of Fallot. They were divided into two groups: 35 patients had crystalloid cardioplegia (controls), and 35 had blood cardioplegia. Lactate and coronary oxygen extraction in arterial blood and the coronary sinus were measured immediately after cessation of cardiopulmonary bypass, 15 and 30 min later. Postoperative mortality, major adverse cardiac events, mechanical ventilation time, inotrope administration, arrhythmias, right ventricular function, intensive care unit and hospital length of stay were observed. Results There were no significant differences in clinical outcomes or lactate levels. There was a significant difference in coronary oxygen extraction immediately and 15 min after cessation of cardiopulmonary bypass ( p = 0.038, p = 0.015). Conclusion Blood cardioplegia gave a better postoperative oxygen extraction value but there were no differences in myocardial damage or clinical outcome between the two groups.
Fundamental clinical skills of adult cardiopulmonary bypass: results of the 2017 national survey
Authors: Searles Bruce , Darling Edward , Riley Jeffrey , Wiles Jason R. 
Published: December 2018

Introduction: Training students to become entry-level perfusionists requires evaluation and assessment of their clinical skills. While our professional organizations have compiled resources which identify the profession’s knowledge base and categorical skills applied to clinical practice, these resources are lacking the necessary detail to develop validated clinical assessment rubrics. Therefore, the purpose of this project is to identify, through expert opinion, the detailed fundamental skills necessary to perform adult cardiopulmonary bypass (CPB). Methods: We define a fundamental skill based upon frequency of use and risk of harm. A skill that experts report is conducted in >50% of their CPB cases – and, if not properly conducted, can cause harm, is deemed a fundamental skill. To identify these skills, a 73-question survey was developed and posted on PerfList and PerfMail from May 2017 to July 2017. Results: The results from 261 respondents were analyzed. The demographics of the participants were representative of the workforce. Twenty skills were surveyed and all 20 met the criteria to be identified as a fundamental skill. Data regarding the actions, assessments and behaviors that may be associated with fundamental skills were also identified. Conclusions: Based upon this survey data, we have identified that there is consensus within our profession regarding the fundamental skills of adult CPB and a core body of actions, assessments and behaviors that experts perform when conducting these skills. This information may be incorporated into the entry-level educational process to inform curricula and design valid assessment rubrics.
Impacts of Real Depreciation and Appreciation on Aggregate Output in Taiwan
Authors: Hsing Yu 
Published: December 2018

Extending the IS-MP-AS model, this article finds that real depreciation helped to raise real gross domestic product (GDP) during 1999.Q1-2010.Q2 whereas real appreciation helped to increase real GDP during 2010.Q3-2016.Q4. In addition, a lower world real interest rate, a higher stock price, a higher real oil price or a lower expected inflation would increase real GDP. More deficit spending as a percent of GDP does not affect real GDP.JEL Classification: F41, E62
Bibliometric and Textual Analysis of Historical Patterns in Maternal–Infant Health and Nursing Issues in The Canadian NurseJournal, 1905–2015
Authors: Marcellus Lenora 
Published: December 2018

Study background Journals are key learning mechanisms for nursing organizations. Analysis of publications provides opportunities to explore influences, priorities, and perspectives of nurses over time. Purpose To identify historical trends in maternal–infant health and nursing practice. Methods Historical bibliometric and content analysis of articles in The Canadian Nurse, 1905–2015. Six hundred sixty-eight lead publications in the journal were identified. Data were extracted on authorship, writing style, geographical distribution, and language, and content themes were determined. Results Five hundred twenty-five publications were written by nurses, and 272 came from the Ontario and Quebec. Nine key content areas were identified, including changing families, women’s bodies, prenatal care, birth care, postpartum care, when things go wrong, and keeping babies healthy. The number of maternal–infant publications in this national journal has been decreasing since the emergence of specialty journals. Conclusion Advances in perinatal nursing practice over the past 115 years in Canada reflect emerging scientific developments and evolving social values. These articles traced the medicalization and reclamation of pregnancy and childbirth, the shifting role of nurses in relation to other health and social care providers, and the impact of determinants of health on the well-being of mothers, infants, and families.
Prevalence of Deep Vein Thrombosis in Low-Risk Patients After Elective Foot and Ankle Surgery
Authors: Sullivan Martin , Eusebio Ilian Dominiq , Haigh Kristin , Panti Juan Paulo , Omari Abdullah , Hang Jacqueline R. 
Published: December 2018

Background: The evidence regarding the prevalence of deep vein thrombosis (DVT) after foot and ankle surgery in elective patients that need to be 6 weeks non–weight bearing postoperatively is incomplete and has limitations. Methods: The prevalence of DVT in 114 procedures involving the hindfoot and midfoot was determined using ultrasonographic surveillance at 2 and 6 weeks after surgery. Results: The prevalence of DVT was observed to be 25.4%. The majority (68.9%) of DVTs were diagnosed at the ultrasonographic scan performed 2 weeks postoperatively. The remainder (31.1%) of DVTs were diagnosed at the 6-week postoperative ultrasonographic scan. At least 75% of the patients who had early and late DVT had no clinical symptoms or signs of DVT. The prevalence of DVT in clinically detectable patients was 6%. The average age of patients with early DVT was 62.2 years, significantly higher compared to those who had no DVT. The mean tourniquet time for patients with early DVT was 68.1 minutes, significantly higher compared to those without DVT. All DVTs detected were distal to the popliteal vein. Conclusions: The prevalence of clinically silent DVT was significantly higher than was previously thought. We believe this increased rate is directly attributable to the use of ultrasonographic surveillance postsurgery both at 2 and 6 weeks. The risk of DVT continued after the 2-week visit, and 30% of the DVTs were detected at the ultrasonographic scan at 6 weeks. Level of Evidence: Level II, prospective cohort.
Supination External Rotational Ankle Fracture Injury Pattern Correlation With Regional Bone Density
Authors: Warner Stephen J. , Gausden Elizabeth B. , Levack Ashley E. , Lorich Dean G. 
Published: December 2018

Background: Rotational ankle fractures can present with an array of possible osseous and ligamentous injury combinations in reliable anatomic locations. What accounts for these different injury patterns and whether specific patient and injury factors underlie the different injury patterns is unclear. The purpose of this study was to determine whether causative factors exist that could account for the various injury patterns seen with rotational ankle fractures. Methods: A registry of operatively treated supination external rotation stage IV (SER IV) ankle fractures was used to identify patients. Computed tomography imaging was used to calculate regional bone density by using average Hounsfield unit measurements on axial images from the distal tibia and fibula. Patients were grouped into those with no posterior or medial malleolar fracture (equivalent group), those with either a posterior or medial malleolus fracture (bimalleolar group), and those with both posterior and medial malleolar fractures (trimalleolar group). Sixty-seven patients met inclusion criteria. Results: Regional bone density at the ankle, as measured with Hounsfield units, was significantly higher in the equivalent group (371) than in the bimalleolar group (271, P < .0001) and trimalleolar group (228, P < .0001). Logistic regression analyses identified regional bone density as a significant predictor of a medial malleolus fracture ( P = .002) and of a posterior malleolus fracture ( P = .005). Conclusion: In our cohort of SER IV ankle fractures, regional bone density at the ankle significantly correlated with the presence and number of malleolar fractures compared with ligamentous ruptures. Treating surgeons can use this information to anticipate bone quality during operative fixation based on ankle fracture injury pattern. In addition, the presence of a trimalleolar ankle fracture was a significant indicator of poor bone quality and may represent the first clinical sign of abnormal bone metabolism in many patients. Level of Evidence: Level III, prognostic retrospective cohort study.
Prevalence and impact of self‐reported irritable bowel symptoms in the general population
Authors: Van den Houte K , Carbone F , Pannemans J , Corsetti M , Fischler B , Piessevaux H , Tack J 
Published: December 2018

Background and aimsThe symptom‐based diagnostic criteria for irritable bowel syndrome (IBS) have recently been revised in the Rome IV consensus. On the other hand, with rising public awareness of IBS, self‐diagnosis and self‐management is also increasing. We compared the prevalence and impact of Rome IV‐based IBS vs self‐diagnosed IBS in the general population.MethodsAn internet panel filled out an online survey on bowel symptoms and their impact on health care utilization and daily activities.ResultsA representative internet panel of 1012 individuals completed the online survey. Bowel symptoms were present in 68.6% of the population. Of these, 21% consulted a physician for these symptoms in the last year and 42% earlier. Rome IV IBS criteria were fulfilled by 5.5%, and these were younger and more likely to be female. In this subset, 37% had consulted a physician for IBS symptoms in the preceding year and 29% had done so earlier. A colonoscopy had been performed in 22%. Based on a brief description, 17.6% of the population self‐identified as suffering from IBS (p < 0.001 compared to Rome IV IBS prevalence), and these were more likely to be female. Concordance with the Rome IV criteria was only 25%, but except for a lower reporting of pain, the symptom pattern, severity, impact on daily life, inability to work and health care utilization were similar to the Rome IV group. A total of 134 days of absence from work were attributed to bowel symptoms in those self‐reporting with IBS.ConclusionIn the general population, bowel symptoms are highly prevalent, and the self‐reported “IBS” is three times more prevalent than according to Rome IV criteria. Self‐reported IBS is associated with a similar impact on health care utilization and quality of life but a higher impact on absence from work.
RETRACTED ARTICLE: SIRT6 drives epithelial-to-mesenchymal transition and metastasis in non-small cell lung cancer via snail-dependent transrepression of KLF4
Authors: Li Ziming , Huang Jia , Shen Shengping , Ding Zhenping , Luo Qingquan , Chen Zhiwei , Lu Shun 
Published: December 2018

Abstract
Background
Epithelial-to-mesenchymal transition (EMT) contributes to the invasion and metastasis of epithelial tumors. Sirtuin 6 (SIRT6), an NAD-dependent deacetylase, is known to promote metastasis of non-small cell lung cancer (NSCLC).

Methods
In this work, we determined the role of SIRT6 in the EMT of NSCLC cells and identified the key EMT-related genes involved in the oncogenic activity of SIRT6.

Results
We report that depletion of SIRT6 inhibits transforming growth factor-β1 (TGF-β1)-induced EMT in A549 and H1299 NSCLC cells, which is rescued by ectopic expression of SIRT6. Knockdown of SIRT6 leads to a reduction in Snail protein without affecting the mRNA level. Immunoprecipitation experiments demonstrate a physical association between SIRT6 and Snail. SIRT6 deacetylates Snail and prevents its proteasomal degradation. Silencing of Snail blunts SIRT6-induced NSCLC cell migration and invasion, while overexpression of Snail restores the invasion and EMT in SIRT6-depleted NSCLC cells. SIRT6 depletion leads to an upregulation of kruppel-like factor 4 (KLF4) and reduced Snail binding to the promoter of Klf4 in NSCLC cells. Knockdown of KLF4 rescues the invasive capacity in SIRT6-depleted NSCLC cells. Conversely, co-expression of KLF4 impairs SIRT6-induced aggressive behavior. In vivo data further demonstrate that SIRT6-induced NSCLC metastasis is antagonized by overexpression of KLF4.

Conclusions
These findings provide mechanistic insights into the pro-metastatic activity of SIRT6 and highlight the role of the SIRT6/Snail/KLF4 axis in regulating EMT and invasion of NSCLC cells.
A curative‐intent endoscopic surgery for postradiation nasopharyngeal necrosis in patients with nasopharyngeal carcinoma
Authors: Zou Xiong , Wang Shun‐Lan , Liu You‐Ping , Liu Yan‐Ling , Zou Ru‐Hai , Zhang Yi‐Nuan , You Rui , Yang Qi , Xie Yu‐Long , Lin Mei , Huang Pei‐Yu , Jiang Rou , Zhang Meng‐Xia , Qian Chao‐Nan , Mai Hai‐Qiang , Guo Ling , Hong Ming‐Huang , Chen Ming‐Yuan 
Published: December 2018

AbstractBackgroundPostradiation nasopharyngeal necrosis (PRNN) is a severe complication after radiotherapy in patients with nasopharyngeal carcinoma (NPC), which can severely affect the quality of life and threaten the patient's life. Only 13.4%–28.6% of patients can be cured by traditional repeated endoscopic debridement. Here, we introduced an innovative curative‐intent endoscopic surgery for PRNN patients and evaluated its clinical efficacy.MethodsClinical data of 72 PRNN patients who underwent radical endoscopic necrectomy, followed by reconstruction using a posterior pedicle nasal septum and floor mucoperiosteum flap were analyzed to determine the efficacy of this surgery. The endpoints were complete re‐epithelialization of the nasopharyngeal defect, relief of headache, and overall survival (OS).ResultsAll surgeries were successfully performed without any severe postoperative complications or death. The median value of numeric rating scales of pain decreased from 8 before surgery to 0 after surgery (P < 0.001). Fifty‐one patients (70.8%) achieved complete re‐epithelialization of the nasopharyngeal defect. The number of cycles of radiotherapy (odds ratio [OR], 7.254; 95% confidence interval [CI] 1.035–50.821; P = 0.046), postoperative pathological result (OR, 34.087; 95% CI 3.168–366.746; P = 0.004), and survival status of flap (OR, 261.179; 95% CI 17.176–3971.599; P < 0.001) were independent risk factors of re‐epithelialization of the nasopharyngeal defects. Postoperative pathological result (hazard ratio [HR], 5.018; 95% CI 1.970–12.782; P = 0.001) was an independent prognostic factor for OS. The 2‐year OS rate of the entire cohort was 77.9%.ConclusionCurative‐intent endoscopic necrectomy followed by construction using the posterior pedicle nasal septum and floor mucoperiosteum flap is a novel, safe, and effective treatment of PRNN in patients with NPC.
On the Nature of Human Persons and the Resurrection of the Body
Authors: Goetz Stewart 
Published: December 2018

In this paper, I respond to Joshua Mugg and James T. Turner, Jr's claim that the doctrine of the resurrection requires the numerical sameness of ante- and post-mortem bodies. I argue that they have not shown that Scripture teaches this view and, therefore, that animalism, as opposed to substance dualism, does not offer a superior explanation for the necessity of the resurrection .
The effect of plate design, bridging span, and fracture healing on the performance of high tibial osteotomy plates
Authors: MacLeod A. R. , Serrancoli G. , Fregly B. J. , Toms A. D. , Gill H. S. 
Published: December 2018

Objectives Opening wedge high tibial osteotomy (HTO) is an established surgical procedure for the treatment of early-stage knee arthritis. Other than infection, the majority of complications are related to mechanical factors – in particular, stimulation of healing at the osteotomy site. This study used finite element (FE) analysis to investigate the effect of plate design and bridging span on interfragmentary movement (IFM) and the influence of fracture healing on plate stress and potential failure. Materials and Methods A 10° opening wedge HTO was created in a composite tibia. Imaging and strain gauge data were used to create and validate FE models. Models of an intact tibia and a tibia implanted with a custom HTO plate using two different bridging spans were validated against experimental data. Physiological muscle forces and different stages of osteotomy gap healing simulating up to six weeks postoperatively were then incorporated. Predictions of plate stress and IFM for the custom plate were compared against predictions for an industry standard plate (TomoFix). Results For both plate types, long spans increased IFM but did not substantially alter peak plate stress. The custom plate increased axial and shear IFM values by up to 24% and 47%, respectively, compared with the TomoFix. In all cases, a callus stiffness of 528 MPa was required to reduce plate stress below the fatigue strength of titanium alloy. Conclusion We demonstrate that larger bridging spans in opening wedge HTO increase IFM without substantially increasing plate stress. The results indicate, however, that callus healing is required to prevent fatigue failure. Cite this article: A. R. MacLeod, G. Serrancoli, B. J. Fregly, A. D. Toms, H. S. Gill. The effect of plate design, bridging span, and fracture healing on the performance of high tibial osteotomy plates: An experimental and finite element study. Bone Joint Res 2018;7:639–649. DOI: 10.1302/2046-3758.712.BJR-2018-0035.R1.
Docking studies of tetra substituted pyrazolone derivatives as potential antiviral agents
Authors: Achuthanandhan Jyothi , Lakshmanan Baskar 
Published: December 2018

In an attempt to find potential antiviral agents, a series of pyrazolones (PA1-PA6&Â PC1-PC6)Â were designed and evaluated for theirÂ Â DENVNS5 (RNA-dependent RNA polymerase) inhibitory activity. Molecular docking studies of all the designed compounds into the binding site ofÂ DENVNS5 (PDB Code: 4C11) were performed to gain a comprehensive understanding into rational binding modes. These compounds were also screened forÂ in silicoÂ drug-likeliness properties on the basis of the absorption, distribution, metabolism and excretion (ADME) prediction. Among all the synthesized compounds, analogueÂ Â PA6showed superior inhibitory activity against RNA dependent RNA polymerase.Â SARÂ Â study indicated that the presence of an electron withdrawing substitution on pyrazolone derivatives significantly improves its binding interaction with the protein.Results of ADME prediction revealed that most of these compounds showedÂ in silicoÂ drug-likeliness.
Estimating the Impact of Ride-Hailing App Company Entry on Public Transportation Use in Major US Urban Areas
Authors: Nelson Erik , Sadowsky Nicole 
Published: December 2018

Abstract
Since 2011, the private ride-hailing (RH) app companies Uber and Lyft have expanded into more and more US urban areas. We use a dynamic entry event study to examine the impact of Uber and Lyft’s entry on public transportation (PT) use in the United States’ largest urban areas. In most cases, entry into urban areas was staggered: Uber entered first, followed several months later by Lyft. We generally find that PT use increased in the representative urban area, all else equal, immediately following first RH app company entry. However, this spike in PT use largely disappeared following the entry of the second RH app company. Slightly different RH app company–PT use relationships emerge when we estimate the PT use model over various subsets of urban areas and PT modes.
Phylogenetic analysis of Aquilaria Lam. (Thymelaeaceae) based on DNA barcoding
Authors: Feng Tingting , Li Qiwei , Wang Yesheng , Qiu Simin , He Mengling , Zhang Weimin , Dong Jun , Zhu Shuang 
Published: December 2018

Abstract

Aquilaria Lam. is an important group of trees that produce agarwood, which is widely used for manufacturing medicine, perfumes and incense. The members of the genus Aquilaria are close to being extinct due to illegal harvesting and are now protected in many countries. In this study, five DNA barcodes [internal transcribed spacer (ITS), maturase K (matK), psbA-trnH, ribulose bisphosphate carboxylase (rbcL) and trnL-trnF] and their combinations were evaluated for the discrimination of the major (16 out of 21) species of Aquilaria based on three criteria: sequence variation, genetic distances and the discrimination ability. In addition, we attempted to determine the phylogenetic relationship between Aquilaria and Gyrinops species using three phylogenetic analysis methods. We observed that the combination barcode ITS+trnL-trnF had a good discrimination ability based on the best match and best close match methods, provided more genetic information, and clearly indicated the comprehensive phylogenetic relationship between most Aquilaria and Gyrinops species. Considering the overall performance of these barcodes, the ITS+trnL-trnF is a suitable barcode for the identification of Aquilaria species.
Towards better UV-blocking and antioxidant performance of varnish via additives based on lignin and its colloids
Authors: Tan Shanyuan , Liu Di , Qian Yong , Wang Jingyu , Huang Jinhao , Yi Conghua , Qiu Xueqing , Qin Yanlin 
Published: December 2018

Abstract
Organosolv lignin (OL) extracted from pine wood was self-assembled into uniform nanocolloidal spheres (OLCS) in acetone/water and blended with varnish for better UV-blocking and antioxidant performance. The UV transmittance of the varnish with 1% OL was lower than that of a commercial varnish containing synthetic UVA and UVB blocker. Samples coated with OL-based varnish and UV irradiated for 100 h showed 84 and 69% less color change, respectively, compared to that of pure and commercial varnishes. Due to the higher surface area and better compatibility, the varnish blended with 1% OLCS showed better UV-blocking and photostability than those based on 1% OL additive. The color change of varnish was not perceptible. The lignin-based additives significantly enhanced the hardness and adhesion performance of the varnish and had little influence on the esthetic appearance of the samples. The hardness and modulus of elasticity of varnish increased by 61 and 36%, respectively, in the presence of 1% OLCS. The possible enhancement mechanism was explained by molecular interaction forces.