bluuebunny/crossref_metadata_2025_split huggingface dataset:
Corporate social responsibility against workers?
Authors: Séhier Clément 
Published: January 2019

Purpose
This paper aims to investigate to what extent and for which reasons the codes of conduct and social audits of multinational corporations (MNCs) have failed to change practices within Chinese factories. A special attention is given to the social compliance initiatives (SCIs) and multi-stakeholder initiatives (MSIs) which did not overcome the main obstacles of the compliance approach.

Design/methodology/approach
This research is based on a fieldwork in China, including 36 semi-constructed interviews with practitioners involved in corporate social responsibility (CSR), participant observation in the CSR programme of the International Labour Organisation office in Beijing and several visits of factories involved in CSR programmes. Secondary sources are used to estimate the distribution of value added along global value chains (GVCs).

Findings
The codes of conduct and social audits tend to reproduce the domination of MNCs within GVCs. This paper highlights some obstacles – and opportunities – for CSR appropriate to the Chinese context.

Research limitations/implications
Only a few MNCs agreed to meet the author and speak openly. No one allowed the author to visit their suppliers’ factories.

Practical implications
The findings of this study suggest that the most widespread approach to CSR by MNCs is flawed. More attention should be given to specific institutional contexts and to workers’ participation.

Originality/value
CSR discourse and practices in China are put in the context of GVCs and in the transformation of Chinese industry and labour relations. This method allows going beyond a case study approach. Instrumentations of several SCIs and MSIs are also analysed in detail.
Comprehensive DNA barcodes for species identification and discovery of cryptic diversity in mayfly larvae from South Korea: Implications for freshwater ecosystem biomonitoring
Authors: Suh Kyong In , Hwang Jeong Mi , Bae Yeon Jae , Kang Ji Hyoun 
Published: January 2019

AbstractDNA barcoding of aquatic macroinvertebrates holds much promise as a tool for taxonomic research and for providing baseline reference for phylogenetic analysis and aquatic ecosystem biomonitoring. We obtained 112 novel sequences of the barcode region of the mitochondrial DNA cytochrome c oxidase subunit I gene representing 11 families, 25 genera, and 43 species of mayfly (Insecta: Ephemeroptera) from South Korea. No species shared barcode sequences and all can be identified with barcodes with a possible exception of some species. Minimum levels of interspecific genetic distances ranged from 6.7 to 32.9% (mean: 23.7%), whereas average levels of intraspecific divergence was 3.7%. The latter value was inflated by the presence of very high divergences within some taxa. In fact, approximately 33.3% (15/45) of the species included two or more haplotype clusters showing greater than 5.0% sequence divergence and some values were as high as 32.9%. Many of the species with high intraspecific divergences are para‐ or polyphyletic and represent the possibility of species complexes. Our study suggests that type or topotype specimens should be sequenced to identify accurate barcoding clusters with morphological species concepts and also to determine the status of currently synonymized species.
Diverse human leukocyte antigen association of type 1 diabetes in north India
Authors: Kumar Neeraj , Mehra Narinder K. , Kanga Uma , Kaur Gurvinder , Tandon Nikhil , Chuzho Neihenuo , Mishra Gunja , Neolia Shekhar C. 
Published: January 2019

AbstractBackgroundType 1 diabetes (T1D) is a complex disease, with involvement of various susceptibility genes. Human leukocyte antigen (HLA) on chromosome 6p21 is major susceptibility region. This study examined genetic association of HLA genes with T1D.MethodsThe study recruited 259 T1D patients and 706 controls from north India. PCR‐SSP and LiPA were used to type HLA Class I and II alleles.ResultsAt HLA Class I locus, HLA‐A*02, A*26, B*08 and B*50 were significantly increased in patients vs controls (39.8% vs 28.9% [Bonferroni‐corrected P {Pc} = 0.032], 24.7% vs 9.6% [Pc = 4.83 × 10−8], 37.2% vs 15.7% [Pc = 1.92 × 10−9], and 19.4% vs 5.5% [Pc = 4.62 × 10−9], respectively). Similarly, in Class II region, DRB1*03 showed a strong positive association with T1D (78.7% vs 17.5% in controls; P = 1.02 × 10−9). Association of DRB1*04 with T1D (28.3% vs 15.5% in controls; Pc = 3.86 × 10−4) was not independent of DRB1*03. Negative associations were found between T1D and DRB1*07, *11, *13, and *15 (13.8% vs 26.1% in controls [Pc = 0.00175], 3.9% vs 16.9% in controls [Pc = 6.55× 10−6], 5.5% vs 21.6% in controls [Pc = 2.51 × 10−7], and 16.9% vs 43.9% in controls [Pc = 9.94× 10−10], respectively). Compared with controls, patients had significantly higher haplotype frequencies of A*26‐B*08‐DRB1*03‐DQA1*05‐DQB1*02 (10.43% vs 1.96%; P = 7.62 × 10−11), A*02‐B*50‐DRB1*03‐DQA1*05‐DQB1*02 (6.1% vs 0.71%; P = 2.19 × 10−10), A*24‐B*08‐DRB1*03‐DQA1*05‐DQB1*02 (4.72% vs 0.8%; P = 5.4 × 10−7), A*02‐B*08‐DRB1*03‐DQA1*05‐DQB1*02 (2.36% vs 0.18%; P = 3.6 × 10−5), and A*33‐B*58‐DRB1*03‐DQA1*05‐DQB1*02 (4.33% vs 1.25%; P = 0.00019).ConclusionsIn north India, T1D is independently associated only with HLA‐DRB1*03 haplotypes, and is negatively associated with DRB1*07, *11, *13, and *15.
Fusarium equiseti is associated with the wilt and dieback of Aquilaria malaccensis in Northeast India
Authors: Pandey Shailesh , Rishi R Raja , Jayaraj RSC , Giri Krishna , Kumar Rajesh , Pandey Amit , Juwantha Ranjana , Madaan Sheeba , Bhandari Maneesh S. 
Published: January 2019

AbstractAquilaria malaccensis, categorized by IUCN as globally vulnerable, is in high demand in the Middle East and Asian markets for its unique resinous agarwood. In August 2015, symptoms of dieback were observed on A. malaccensis trees planted in the Medicinal and Aromatic Plant Garden, Panbari, Golaghat of the Assam Forest Department. The entire crowns of 70 trees showed complete leaf loss and severe dieback. Rotting at the collar region and of roots was also observed. Isolation from the infected roots consistently yielded Fusarium equiseti identified following standard laboratory procedures and analysis of the internal transcribed spacer (ITS) sequence of the ribosomal DNA. Symptoms of wilt, dieback and root rot were observed on 5‐month‐old Aquilaria seedlings 25 days after inoculation with the isolated fungus. This paper is the first report of F. equiseti causing wilt and dieback of A. malaccensis.
Individual differences in attentional capability are linked to creative decision making
Authors: Hüttermann Stefanie , Memmert Daniel , Nerb Josef 
Published: January 2019

AbstractThere is a link between visual attention and creativity concerning the generation of rare and flexible decisions/solutions. However, the relationship between individual differences in attentional capability and creative decision making has not yet been investigated in detail. The current study scrutinized this link in a sport‐specific divergent thinking task including videos of real game situations and compared performances between football players being divided into two different expertise levels (expert and amateur football players). We conducted a multiple linear regression analysis to assess whether attentional capability along the attentional focus’ meridians (horizontal, vertical, diagonal) and participants’ expertise level predict creative decision making. The attentional capability along the horizontal meridian of participants’ attentional focus and participants’ expertise level emerged as positive predictors. The findings provide evidence of a relationship between football players’ spatial distribution of attention that match the demands of their sport and an expertise advantage in sport‐specific creative decision making. Implications are not only important for sports, but also for all areas in which spatial attention is required in order to generate unusual solutions.
HMGA1 in cancer: Cancer classification by location
Authors: Wang Yuhong , Hu Lin , Zheng Yushuang , Guo Lingchuan 
Published: January 2019

AbstractThe high mobility group A1 (HMGA1) gene plays an important role in numerous malignant cancers. HMGA1 is an oncofoetal gene, and we have a certain understanding of the biological function of HMGA1 based on its activities in various neoplasms. As an architectural transcription factor, HMGA1 remodels the chromatin structure and promotes the interaction between transcriptional regulatory proteins and DNA in different cancers. Through analysis of the molecular mechanism of HMGA1 and clinical studies, emerging evidence indicates that HMGA1 promotes the occurrence and metastasis of cancer. Within a similar location or the same genetic background, the function and role of HMGA1 may have certain similarities. In this paper, to characterize HMGA1 comprehensively, research on various types of tumours is discussed to further understanding of the function and mechanism of HMGA1. The findings provide a more reliable basis for classifying HMGA1 function according to the tumour location. In this review, we summarize recent studies related to HMGA1, including its structure and oncogenic properties, its major functions in each cancer, its upstream and downstream regulation associated with the tumourigenesis and metastasis of cancer, and its potential as a biomarker for clinical diagnosis of cancer.
Platform competition: Betfair and the UK market for sports betting
Authors: Casadesus‐Masanell Ramon , Campbell Neil 
Published: January 2019

AbstractWe examine two episodes of strategic interaction in the UK betting industry: (a) Betfair (an entrant multisided platform, or MSP) versus Flutter (also an MSP), and (b) Betfair versus traditional bookmakers. We find that although Betfair was an underfunded second mover in the betting exchange space, it was able to attract punters at a much faster rate than the better‐funded first mover, Flutter. Moreover, while Betfair and traditional bookmakers competed aggressively for market share, they also developed a highly complementary relationship that favored all parties. We discuss implications for research in the economics and management of MSPs. Specifically, we argue that the literature would benefit from work that endogenizes platform design and that considers the possible competitive and cooperative interactions between the business models of traditional incumbents and those of potential innovative MSP entrants.
Maltoporin (LamB protein) contributes to the virulence and adhesion of Aeromonas veronii TH0426
Authors: Yang Bintong , Zhang Dongxing , Wu Tonglei , Zhang Zhiqiang , Raza Sayed Haidar Abbas , Schreurs Nicola , Zhang Lei , Yang Guilian , Wang Chunfeng , Qian Aidong , Kang Yuanhuan , Shan Xiaofeng 
Published: January 2019

AbstractAeromonas veronii is one of the main pathogens causing freshwater fish sepsis and ulcer syndrome. More and more cases have shown that it has become an important zoonotic and aquatic agent. In this study, a A. veronii TH0426 mutant strain (ΔlamB) with an in‐frame deletion removed nucleotides 10–1,296 of the lamB gene was firstly constructed to investigate its functions. The results showed that the LD50 value of the mutant ΔlamB to zebrafish and mice was 13.7‐fold and 5.6‐fold higher than those of the wild‐type strain, respectively. The toxicity of wild‐type strain to EPC cells was 2.1‐fold and threefold higher than those of ∆lamB when infected for 1 and 2 hr. Furthermore, the ability of biofilm formation and the adhesion and invasion to EPC cells of ∆lamB significantly decreased for 5.6‐fold and 1.8‐fold separately. In addition, motility detection result indicated that ∆lamB lost the swimming ability. The results of flagellar staining and TEM demonstrated that the flagella of ∆lamB were shed. In general, the deletion of lamB gene caused a significant decrease in the virulence and adhesion of A. veronii TH0426, and it can be known that the lamB gene of A. veronii plays a crucial role in the pathogenesis.
Assessing the safety of beta‐blocker therapy in cirrhosis patients with ascites: A meta‐analysis
Authors: Wong Robert J. , Robinson Ann , Ginzberg Dina , Gomes Chantal , Liu Benny , Bhuket Taft 
Published: January 2019

AbstractBackground & AimsBeta‐blocker therapy is effective at reducing risks of variceal bleeding. However, beta‐blockers may detrimentally exacerbate the underlying haemodynamic changes in cirrhosis. A systematic review and meta‐analysis was performed to evaluate impact of beta‐blockers on all‐cause mortality among cirrhosis patients with ascites.MethodsA literature search identified studies that evaluated beta‐blocker vs no beta‐blocker therapy in cirrhosis patients with ascites. The primary outcome was all‐cause mortality with subcohort analysis of patients with refractory or severe ascites. Quality of observational studies was assessed with Newcastle‐Ottawa Scale and overall certainty of the evidence was assessed using Grading of Recommendations Assessment, Development and Evaluation (GRADE) system.ResultsEight observational studies, representing 3627 cirrhosis patients with ascites (1630 treated with beta‐blockers and 1997 not treated), were included. Pooled all‐cause mortality was 38.6% in beta‐blocker group vs 42.2% in no beta‐blocker group (RR 0.93, 95% CI 0.77‐1.13, χ2 = 54.03, I2 = 87%). Subcohort analysis of cirrhosis patients with refractory or severe ascites demonstrated 33.3% mortality in beta‐blocker group vs 32.1% in no beta‐blocker group (RR 0.99, 95% CI 0.70‐1.40, χ2 = 32.99, and I2 = 82%). Three studies were good quality and five studies were fair quality. GRADE rating was ‘very low’ certainty of evidence, given concern for bias and inconsistency stemming from significant heterogeneity.ConclusionNo significant increase in all‐cause mortality was observed in cirrhosis patients with ascites treated with beta‐blockers. However, given the low certainty of the evidence, high quality prospective studies are needed.
Mechanical stress induced S100A7 expression in human dental pulp cells to augment osteoclast differentiation
Authors: Charoenpong Hataichanok , Osathanon Thanaphum , Pavasant Prasit , Limjeerajarus Nuttapol , Keawprachum Boonrit , Limjeerajarus Chalida N. , Cheewinthamrongrod Vipaporn , Palaga Tanapat , Lertchirakarn Veera , Ritprajak Patcharee 
Published: January 2019

AbstractObjectivesMechanical injury of dental pulp leads to root resorption by osteoclasts/odontoclasts. S100 proteins have been demonstrated to be involved in inflammatory processes and bone remodeling. This study aimed to investigate the effect of mechanical stress on S100A7 expression by human dental pulp cells (HDPCs) and the effect of S100A7 proteins on osteoclast differentiation.Materials and MethodsIsolated HDPCs were stimulated with compressive loading (2 and 6 hr), or shear loading (2, 6, and 16 hr). S100 mRNA expression and S100A7 protein levels were determined by real‐time PCR and ELISA, respectively. Osteoclast differentiation was analyzed using primary human monocytes. The differentiation and activity of osteoclasts were examined by TRAcP staining and dentine resorption. In addition, the expression of S100A7 was analyzed in pulp tissues obtained from orthodontically treated teeth.ResultsCompressive and shear mechanical stress significantly upregulated both mRNA and protein level of S100A7. Dental pulp tissues from orthodontically treated teeth exhibited higher S100A7mRNA levels compared to non‐treated control teeth. S100A7 promoted osteoclast differentiation by primary human monocytes. Moreover, S100A7 significantly enhanced dentine resorption by these cells.ConclusionsMechanical stress induced expression of S100A7 by human dental pulp cells and this may promote root resorption by inducing osteoclast differentiation and activity.
Evaluation of aprepitant and fosaprepitant in pediatric patients
Authors: Saito Yoshimasa , Kumamoto Tadashi , Arima Takamichi , Shirakawa Nami , Ishimaru Sae , Sonoda Tomoko , Nakajima Miho , Sugiyama Masanaka , Arakawa Ayumu , Hashimoto Hironobu , Makino Yoshinori , Ogawa Chitose , Yamaguchi Masakazu 
Published: January 2019

AbstractBackgroundSingle‐dose i.v. fosaprepitant has been approved as an alternative to 3 day oral aprepitant, a neurokinin‐1 receptor antagonist, and improves prevention of chemotherapy‐induced nausea and vomiting (CINV). Because fosaprepitant has shown similar efficacy to aprepitant in adult patients only, this study compared the efficacy and safety of aprepitant and fosaprepitant in pediatric patients.MethodsChildren younger than 18 years who received aprepitant or fosaprepitant to manage CINV between January 2015 and March 2018 at the National Cancer Center Hospital (Tokyo) were recruited to this study. The primary endpoint was complete response (CR; no vomiting/rescue medication) between 0 and 120 h after the start of chemotherapy. Secondary endpoints were safety based on the frequency of severe adverse events, and evaluation of patient characteristics as risk factors (effect of age and sex).ResultsA total of 125 chemotherapy cycles were evaluated. In the aprepitant group, CR was observed in 36 of 80 treatment cycles (45.0%), whereas in the fosaprepitant group, it was observed in 19 of 45 cycles (42.2%; P = 0.852). No treatment‐related severe adverse events were observed in either group. The number of non‐CR was greater than that of CR in patients aged 6–14 years. The difference in CR rate between male and female patients was not statistically significant (47.1% vs 40.0%, respectively; P = 0.471).ConclusionsAprepitant and fosaprepitant were safely used and may be equally useful for pediatric patients receiving highly emetogenic chemotherapy. CR rate may be associated with patient age.
Dissecting through the metallogenic potentials of Precambrian granitoids: case studies from the Bastar and Eastern Dharwar Cratons, India
Authors: Pandit Dinesh , Bhattacharya Sourabh , Panigrahi Mruganka K. 
Published: January 2019

Abstract
The Malanjkhand granodiorite in the Bastar Craton hosts a major copper (+ molybdenum) deposit. It represents a Precambrian granite–ore system lacking in key morphological features of porphyry-type deposits but is comparable as a chemical package with a distinct mode of evolution of the magmatic-hydrothermal system. Mineral chemistry of biotite and apatite along with bulk geochemical data constrain critical parameters such as initial water and halogen contents of the magma. Evolution of the magmatic-hydrothermal fluid has been envisaged with available thermobarometric data. A quantitative ore genetic model in terms of efficiency of removal of metals and resultant mineralization in terms of quantity of metals has been attempted for the Malanjkhand deposit. The Eastern Dharwar Craton witnessed prolific granitic activities in multiple phases during the Late Archean and are spatially close to auriferous schist belts. Against a widely held view of a single metamorphogenic origin of metal and ore fluid, a granite–gold connection can be visualized for the auriferous schist belts of the Eastern Dharwar Craton through comparison of fluid characteristics in the granitoid and ore regimes and mineral chemical constraints. Although a quantitative genetic link between the granitoid and gold would need more data, a magmatic component of the ore fluid could be established based on the available information.
CD38-Driven Mitochondrial Trafficking Promotes Bioenergetic Plasticity in Multiple Myeloma
Authors: Marlein Christopher R. , Piddock Rachel E. , Mistry Jayna J. , Zaitseva Lyubov , Hellmich Charlotte , Horton Rebecca H. , Zhou Zhigang , Auger Martin J. , Bowles Kristian M. , Rushworth Stuart A. 
Published: January 2019

AbstractMetabolic adjustments are necessary for the initiation, proliferation, and spread of cancer cells. Although mitochondria have been shown to move to cancer cells from their microenvironment, the metabolic consequences of this phenomenon have yet to be fully elucidated. Here, we report that multiple myeloma cells use mitochondrial-based metabolism as well as glycolysis when located within the bone marrow microenvironment. The reliance of multiple myeloma cells on oxidative phosphorylation was caused by intercellular mitochondrial transfer to multiple myeloma cells from neighboring nonmalignant bone marrow stromal cells. This mitochondrial transfer occurred through tumor-derived tunneling nanotubes (TNT). Moreover, shRNA-mediated knockdown of CD38 inhibits mitochondrial transfer and TNT formation in vitro and blocks mitochondrial transfer and improves animal survival in vivo. This study describes a potential treatment strategy to inhibit mitochondrial transfer for clinical benefit and scientifically expands the understanding of the functional effects of mitochondrial transfer on tumor metabolism.Significance:Multiple myeloma relies on both oxidative phosphorylation and glycolysis following acquisition of mitochondria from its bone marrow microenvironment.See related commentary by Boise and Shanmugam, p. 2102
p53-Suppressed Oncogene TET1 Prevents Cellular Aging in Lung Cancer
Authors: Filipczak Piotr T. , Leng Shuguang , Tellez Carmen S. , Do Kieu C. , Grimes Marcie J. , Thomas Cynthia L. , Walton-Filipczak Stephanie R. , Picchi Maria A. , Belinsky Steven A. 
Published: January 2019

Abstract

The role of transcriptional regulator ten-eleven translocation methylcytosine dioxygenease 1 (TET1) has not been well characterized in lung cancer. Here we show that TET1 is overexpressed in adenocarcinoma and squamous cell carcinomas. TET1 knockdown reduced cell growth in vitro and in vivo and induced transcriptome reprogramming independent of its demethylating activity to affect key cancer signaling pathways. Wild-type p53 bound the TET1 promoter to suppress transcription, while p53 transversion mutations were most strongly associated with high TET1 expression. Knockdown of TET1 in p53-mutant cell lines induced senescence through a program involving generalized genomic instability manifested by DNA single- and double-strand breaks and induction of p21 that was synergistic with cisplatin and doxorubicin. These data identify TET1 as an oncogene in lung cancer whose gain of function via loss of p53 may be exploited through targeted therapy–induced senescence.

Significance:
These studies identify TET1 as an oncogene in lung cancer whose gain of function following loss of p53 may be exploited by targeted therapy–induced senescence.
See related commentary by Kondo, p. 1751