bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association Between Intravenous Thrombolysis and Anaphylaxis Among Medicare Beneficiaries With Acute Ischemic Stroke
Authors: Lerario Mackenzie P. , Grotta James C. , Merkler Alexander E. , Omran Setareh Salehi , Chen Monica L. , Parikh Neal S. , Yaghi Shadi , Murthy Santosh , Navi Babak B. , Kamel Hooman 
Published: September 2019

Background and Purpose—
Allergic reactions, including anaphylaxis, can sometimes occur after intravenous thrombolysis in patients with acute ischemic stroke. However, it remains unclear whether patients with stroke who receive thrombolytic agents face a higher risk of anaphylaxis than those who do not receive thrombolytics.

Methods—

We performed a retrospective cohort study using inpatient and outpatient claims between 2008 and 2015 from a nationally representative 5% sample of Medicare beneficiaries. We included patients who were ≥65 years old and hospitalized with acute ischemic stroke, defined by validated
International Classification of Diseases, Ninth Revision, Clinical Modification
diagnosis codes. Our exposure was treated with an intravenous thrombolytic agent during the index hospitalization (
International Classification of Diseases, Ninth Revision, Clinical Modification
code 99.10). Our primary outcome was anaphylaxis, defined using an accepted
International Classification of Diseases, Ninth Revision, Clinical Modification
code algorithm (989.5, 995.0-4, 995.6x, E905, E905.3, E905.5, or E905.8-9). A secondary outcome was anaphylactic shock (995.0 or 995.6x). Multiple logistic regression was used to evaluate the association between intravenous thrombolysis and anaphylaxis after adjustment for demographics, vascular risk factors, the Charlson comorbidity index, exposure to intravenous contrast dye, treatment with mechanical thrombectomy, and history of allergic reactions.

Results—
Among 66 989 patients with stroke, the 3176 (4.7%) who underwent intravenous thrombolysis more often had atrial fibrillation (47.7% versus 37.4%) and more often received intravenous contrast dye (44.3% versus 21.9%) but were otherwise similar in terms of demographics and comorbidities. Anaphylaxis developed in 17 (0.54%; 95% CI, 0.31%–0.86%) patients who received intravenous thrombolysis versus 45 (0.07%; 95% CI, 0.05%–0.09%) who did not. After adjustment for demographics, comorbidities, contrast dye, mechanical thrombectomy, and history of allergies, there was a significant association between receipt of intravenous thrombolysis and anaphylaxis (odds ratio, 7.8; 95% CI, 4.3–13.9). We found a similar association for anaphylactic shock.

Conclusions—
Although a rare occurrence, the risk of anaphylaxis among patients with acute ischemic stroke was significantly higher among those who received intravenous thrombolysis.
Two “Mothers” in 5 Ezra 2:1-32
Authors: Bergren Theodore A. 
Published: September 2019

Abstract
The early Christian apocryphon 5 Ezra (2 Esdras) 2:1-32 describes two distinct but unidentified “mothers.” The first (2:1-7) is desolate, forlorn, and consigned to “destruction”; the second (2:15-32) is encouraged, glorified, and triumphant.
It is generally recognized that the first “mother” represents the city of Jerusalem, “Mother Jerusalem.” The identity of and literary/thematic inspiration(s) behind the second “mother,” however, are uncertain.
The main thesis of this paper is that the “mother” in 2:15-32 represents the Christian church, “Mother Church.” The primary evidence for this identification is the remarkable thematic and verbal parallels between 5 Ezra’s descriptions of the “mother” and the characterizations of “Mother Church” in the writings of Cyprian.
Furthermore, the writings of Zeno of Verona and Lactantius contain lists of Christian ecclesiastical “works of mercy” that are close to 5 Ezra 2:20-22.
Our findings suggest that 5 Ezra is a post-250 Latin composition of North African origin.
Unpacking Recipes and Communicating Experience: The Ervarenissen of Simon Eikelenberg (1663-1738) and the Art of Painting
Authors: Hagendijk Thijs 
Published: September 2019

Abstract
This article argues that in the early modern period, epistemic genres were transformed to suit new purposes. Modelled on the experimental essay form used by proponents of the New Sciences, the Dutch polymath and painter Simon Eikelenberg (1663-1738) wrote down ervarenissen to document how painting materials such as varnishes were prepared. Recipes have been identified as the ubiquitous vehicles for written know-how in the early modern period, yet authors continuously searched for new ways to unpack the ineffable dimensions of know-how in text. This article explores the ervarenissen as an alternative communicative strategy. Eikelenberg appropriated the experimental essay to create expressive instructions. He emphasized the specificity and idiosyncrasy of an act of making, tried to establish a sympathetic relationship with his readers, and showed how vulnerability, failure and improvisation belong to the workshop.
The Effect of Drifter GPS Errors on Estimates of Submesoscale Vorticity
Authors: Spydell Matthew S. , Feddersen Falk , Macmahan Jamie 
Published: September 2019

AbstractDifferential kinematic flow properties (DKP), such as vertical vorticity, have been estimated from surface drifters. However, previous DKP error estimates were a posteriori and did not include correlated errors across drifters. To accurately estimate submesoscale (≤1 km) DKPs from drifters, errors must be better understood. Here, the a priori vorticity standard error is derived that depends upon the number of drifters in the cluster, the drifter cluster major and minor axes lengths, the instrument velocity error, and the cross-drifter error correlation. Two stationary GPS experiments, with zero vorticity, were performed at separations of O(101–103) m to understand vorticity error and test the derivation using 1 Hz position differences and Doppler shift velocities. Vorticity errors of ±5f (where f is the local Coriolis parameter)were found for ≈40 m separations. The frequency-dependent velocity variances and GPS-to-GPS correlations are quantified. Vorticity estimated with a “blended” velocity has reduced error. The stationary vorticity error can be well predicted given velocity error, correlation, and minor axis length. Vorticity error analysis is applied to submesoscale-sampling in situ GPS drifters near Point Sal, California. The derivation predicts when large high-frequency vorticity fluctuations (indicating noise) occur. Previously, cluster area or ellipticity were used as criteria to distinguish error. We show that the drifter cluster minor axis (narrowness) is a key time-dependent factor affecting vorticity error, and even for velocity errors <0.004 m s−1, the vorticity error exceeds ±5f when cluster minor axis <50 m. These results will aid submesoscale drifter deployment planning.
Bias Correction of Tropical Cyclone Parameters in the ECMWF Ensemble Prediction System in Australia
Authors: Aijaz Saima , Kepert Jeffrey D. , Ye Hua , Huang Zhendong , Hawksford Alister 
Published: September 2019

Abstract
Global ensemble prediction systems have considerable ability to predict tropical cyclone (TC) formation and subsequent evolution. However, because of their relatively coarse resolution, their predictions of intensity and structure are biased. The biases arise mainly from underestimated intensities and enlarged radii, in particular the radius of maximum winds. This paper describes a method to reduce this limitation by bias correcting TCs in the ECMWF Ensemble Prediction System (ECMWF-EPS) for a region northwest of Australia. A bias-corrected TC system will provide more accurate forecasts of TC-generated wind and waves to the oil and gas industry, which operates a large number of offshore facilities in the region. It will also enable improvements in response decisions for weather sensitive operations that affect downtime and safety risks. The bias-correction technique uses a multivariate linear regression method to bias correct storm intensity and structure. Special strategies are used to maintain ensemble spread after bias correction and to predict the radius of maximum winds using a climatological relationship based on wind intensity and storm latitude. The system was trained on the Australian best track TC data and the ECMWF-EPS TC data from two cyclone seasons. The system inserts corrected vortices into the original surface wind and pressure fields, which are then used to estimate wind exceedance probabilities, and to drive a wave model. The bias-corrected system has shown an overall skill improvement over the uncorrected ECMWF-EPS for all TC intensity and structure parameters with the most significant gains for the maximum wind speed prediction. The system has been operational at the Australian Bureau of Meteorology since November 2016.
Hypoactivity in the Paraterminal Gyrus Following Bilateral Anterior Capsulotomy
Authors: Hurwitz Trevor A. , Honey Christopher R. , McLeod Kevin R. , Poologaindran Anujan , Kuan Annie J. 
Published: September 2019

Objective:Bilateral anterior capsulotomy (BAC) is one of the ablative neurosurgical procedures used to treat major depressive disorder or obsessive-compulsive disorder when all other therapies fail. Tristolysis, a reduction in sadness, is the most striking clinical effect of BAC and is seen in the first 1 to 2 weeks after surgery. This retrospective study measured regional cerebral blood flow (rCBF) following surgery to identify which cortical regions were impacted and could account for this clinical effect.Methods:All patients had their capsulotomies done in Vancouver by the same team. Pre- and postoperative single-photon emission computed tomography perfusion scans were analyzed for 10 patients with major depressive disorder and 3 with obsessive-compulsive disorder. rCBF was measured semiquantitatively by calculating the ratio between an identified region of interest and a whole brain reference area.Results:Decreased rCBF was found in the paraterminal gyri. Increased rCBF was found in the dorsolateral prefrontal cortices and in the left lateral temporal lobe.Conclusions:BAC causes hypoactivity in the paraterminal gyri and is the most likely explanation for its tristolytic effect, suggesting that the paraterminal gyrus is the limbic cortical locus for the emotion of sadness. Increased activity in the dorsolateral prefrontal cortices may be occurring via connectional diaschisis, and suppression by overactive paraterminal gyri during depression may account for some of the neurocognitive deficits observed during depressive episodes.
Nationwide Results on Chronic Pain After Bilateral Transabdominal Preperitoneal Inguinal Hernia Repair
Authors: Johansen N. , Vyrdal C. D. , Bisgaard T. 
Published: September 2019

Background: Majority of studies on chronic postoperative inguinal pain has described the occurrence after unilateral inguinal hernia repair. Endo-laparoscopic repair, for example, laparoscopic transabdominal preperitoneal inguinal hernia repair, has been recommended for primary bilateral symptomatic inguinal hernias, although the literature on chronic postoperative inguinal pain among this type of patients is limited. The present study analyzed chronic postoperative inguinal pain following bilateral transabdominal preperitoneal inguinal hernia repair. Methods: Nationwide consecutive patients who underwent bilateral transabdominal preperitoneal inguinal hernia repair (July 2012–June 2013) were recruited from the Danish Inguinal Hernia Database and cross-checked with hospital files and the National Patient Registry. A prospective follow-up was performed with a standardized postal questionnaire including questions on functional performance status assessed by a modified version of the Activity Assessment Scale. The primary outcome was incidence of chronic postoperative inguinal pain defined as moderate to severe pain-related impairment of everyday activities. Pain was registered according to the two individual groin areas. Furthermore, the overall incidence of chronic postoperative inguinal pain per operated inguinal hernia was calculated. Intensity of experienced pain (Activity Assessment Scale score) was compared between patients reporting pain from one versus both groin areas. Results: In total, 209 patients (418 hernia repairs) were analyzed (questionnaire response rate 83%). The median follow-up time was 27 months (22–34 months). In total, 27 of 209 patients (13%) complained of chronic postoperative inguinal pain from either one ( n = 17) or both ( n = 10) groin areas after bilateral transabdominal preperitoneal inguinal hernia repair. The incidence of chronic inguinal pain per operated hernia was 9%. The intensity of impairment due to pain (Activity Assessment Scale score) did not differ significantly between patients with chronic postoperative inguinal pain in one (19%) versus both sides (30%), p = 0.056. Conclusion: Bilateral transabdominal preperitoneal inguinal hernia repair for symptomatic inguinal hernias was related to a high incidence (13%) of chronic postoperative inguinal pain and decreased functional performance status.
Mediated effects of insomnia, psychological distress and medication adherence in the association of eHealth literacy and cardiac events among Iranian older patients with heart failure: a longitudinal study
Authors: Lin Chung-Ying , Ganji Maryam , Griffiths Mark D , Bravell Marie Ernsth , Broström Anders , Pakpour Amir H 
Published: September 2019

Background: Given the importance of improving health for patients with heart failure, the present study examined the temporal associations between eHealth literacy, insomnia, psychological distress, medication adherence, quality of life and cardiac events among older patients with heart failure. Methods: With a longitudinal design older patients with echocardiography verified heart failure ( N=468; 50.4% New York Heart Association class II, mean age 69.3±7.3 years; 238 men) in need of cardiac care at seven Iranian university outpatient clinics went through clinical examinations and completed the following questionnaires at baseline: eHealth literacy scale (eHEALS, assessing eHealth literacy); 5-item medication adherence report scale (MARS-5, assessing medication adherence); Minnesota living with heart failure questionnaire (MLHFQ, assessing quality of life); insomnia severity index (ISI, assessing insomnia); and hospital anxiety and depression scale (HADS, assessing psychological distress). All the patients completed the ISI and HADS again 3 months later; and the MARS-5 6 months later. Also, their cardiac events were collected 18 months later. Three mediation models were then conducted. Results: eHealth literacy had direct and indirect effects (through insomnia and psychological distress) on medication adherence and quality of life. Moreover, eHealth literacy had protecting effects on cardiac events (hazard ratio (HR) 0.53; 95% confidence interval (CI) 0.37, 0.65) through the mediators of insomnia (HR 0.19; 95% CI 0.15, 0.26), psychological distress (HR 0.08; 95% CI 0.05, 0.12) and medication adherence (HR 0.05; 95% CI 0.04, 0.08). Conclusion: As eHealth literacy was a protector for patients with heart failure, healthcare providers may plan effective programmes to improve eHealth literacy for the population. Additional benefits of improving eHealth literacy in heart failure may be decreased insomnia and psychological distress, improved quality of life, as well as decreased cardiovascular events.
Impact of intravenous thrombolysis on functional outcome in patients with mild ischemic stroke without large vessel occlusion or rapidly improving symptoms
Authors: Haeberlin Marcellina Isabelle , Held Ulrike , Baumgartner Ralf W , Georgiadis Dimitrios , Valko Philipp O 
Published: September 2019

Background Optimal treatment strategy in patients with mild ischemic stroke remains uncertain. While functional dependency or death has been reported in up to one-third of non-thrombolyzed mild ischemic stroke patients, intravenous thrombolysis is currently not recommended in this patient group. Emerging evidence suggests two risk factors—rapid early improvement and large vessel occlusion—as main associates of unfavorable outcome in mild ischemic stroke patients not undergoing intravenous thrombolysis. Aims To analyze natural course as well as safety and three-month outcome of intravenous thrombolysis in mild ischemic stroke without rapid early improvement or large vessel occlusion. Methods Mild ischemic stroke was defined by a National Institute of Health Stroke Scale score ≤6. We used the modified Rankin Scale (mRS) to compare three-month functional outcome in 370 consecutive mild ischemic stroke patients without early rapid improvement and without large vessel occlusion, who either underwent intravenous thrombolysis (n = 108) or received best medical treatment (n = 262). Results Favorable outcome (mRS ≤ 1) was common in both groups (intravenous thrombolysis: 91%; no intravenous thrombolysis: 90%). Although intravenous thrombolysis use was independently associated with a higher risk of asymptomatic hemorrhagic transformation (OR = 4.62, p = 0.002), intravenous thrombolysis appeared as an independent predictor of mRS = 0 at three months (OR = 3.33, p < 0.0001). Conclusions Mild ischemic stroke patients without rapidly improving symptoms and without large vessel occlusion have a high chance of favorable three-month outcome, irrespective of treatment type. Patients receiving intravenous thrombolysis, however, more often achieved complete remission of symptoms, which particularly in mild ischemic stroke may constitute a meaningful endpoint.
Trends in Alveolar Bone Grafting and the Use of Recombinant Bone Morphogenetic Protein (RhBMP) in the United States
Authors: Kanack Melissa , Krasnoff Chloe , Daly Lauren , Laurence Vincent , Jaffurs Daniel 
Published: September 2019

Objectives: To gather information about current practices and assess the opinions, preferences, and clinical knowledge of surgeons who perform alveolar bone grafts. In addition, surgical training differences in correlation to techniques and outcomes are evaluated. Methods: A survey with both multiple choice and narrative answers regarding surgeons’ practices for alveolar bone grafting was designed and sent via email to members of the American Cleft Palate/Craniofacial Association (ACPA) identified as general craniofacial or oral maxillofacial surgeons. Responses were collected via an anonymous online survey tool. Participants: Members (336) of ACPA identified as craniofacial or oral-maxillofacial surgeons were contacted, and 62 responses were recorded. Results: The majority of survey respondents were oral-maxillofacial surgeons in practice for more than 15 years. 98.4% of respondents had used iliac crest and at least one additional source for grafting, while only 52.7% had performed grafting using recombinant bone morphogenetic protein (RhBMP). 82% used cone beam CT as their evaluation of choice for graft assessment and the majority (62.9%) waited more than 8 weeks postoperatively to image. Chi-square analysis demonstrated significantly longer time in practice for practitioners without craniofacial fellowship training. Conclusions: The results of this study demonstrate that there remains significant variation in alveolar bone grafting practices among surgeons. While some consensus exists, new innovations and technologies will require continued evaluation of surgical practices and outcomes. Long-term follow-up studies are needed especially with regard to the use of RhBMP in alveolar clefts.
Synergistically Enhanced Inhibitory Effects of Pullulan Nanoparticle-Mediated Co-Delivery of Lovastatin and Doxorubicin to Triple-Negative Breast Cancer Cells
Authors: Wu Di , Chen Yao , Wen Shun , Wen Yi , Wang Rong , Zhang Qiuting , Qin Ge , Yi Huimei , Wu Mi , Lu Lu , Tao Xiaojun , Deng Xiyun 
Published: September 2019

Abstract
Triple-negative breast cancer (TNBC) is a subtype of breast cancer that is prone to drug resistance and difficult to treat. In this study, we grafted water-soluble pullulan with lovastatin (LV) to develop a novel amphiphilic conjugate, pullulan-encapsulated LV (PLV). The PLV conjugate was synthesized with three different ratios of pullulan to LV and characterized by Fourier transform infrared (FTIR). The degree of substitution (DS) of LV in terms of molar ratio was 7.87%, 3.58%, and 3.06% for PLV (1/2), PLV (1/3), and PLV (1/4), respectively, by proton NMR analysis. We selected the PLV (1/2) conjugate to prepare doxorubicin (DXR)-loaded PLV nanoparticles (PLV/DXR NPs) because of its superior properties. The average size and zeta potential for PLV (1/2) NPs were 177.6 nm and − 11.66 mV, respectively, determined by dynamic light scattering, and those for PLV/DXR NPs were 225.6 nm and − 10.51 mV, respectively. In vitro drug release profiling showed that PLV/DXR NPs sustainably released DXR within 72 h, which was more robust at pH 5.4 (97.90%) than pH 7.4 (76.15%). In the cytotoxicity study, PLV/DXR NPs showed greater inhibition of proliferation of TNBC MDA-MB-231 than non-TNBC MDA-MB-453 cells (IC50 0.60 vs 11.05 μM). FITC-loaded PLV/DXR NPs were prepared to investigate cellular uptake: both cell lines showed a time-dependent uptake of NPs, but the number of NPs entering MDA-MB-231 cells was greater than that entering the MDA-MB-453 cells. Pullulan-based NP co-delivery of LV and DXR could efficiently inhibit TNBC cells, which may help in designing a powerful drug delivery system for treating TNBC.
Within-task variability on standardized language tests predicts autism spectrum disorder: a pilot study of the Response Dispersion Index
Authors: Hare-Harris Abby E. , Mitchel Marissa W. , Myers Scott M. , Mitchel Aaron D. , King Brian R. , Ruocco Brittany G. , Martin Christa Lese , Flax Judy F. , Brzustowicz Linda M. 
Published: September 2019

Abstract

Background
Qualitatively atypical language development characterized by non-sequential skill acquisition within a developmental domain, which has been called developmental deviance or difference, is a common characteristic of autism spectrum disorder (ASD). We developed the Response Dispersion Index (RDI), a measure of this phenomenon based on intra-subtest scatter of item responses on standardized psychometric assessments, to assess the within-task variability among individuals with language impairment (LI) and/or ASD.

Methods
Standard clinical assessments of language were administered to 502 individuals from the New Jersey Language and Autism Genetics Study (NJLAGS) cohort. Participants were divided into four diagnostic groups: unaffected, ASD-only, LI-only, and ASD + LI. For each language measure, RDI was defined as the product of the total number of test items and the sum of the weight (based on item difficulty) of test items missed. Group differences in RDI were assessed, and the relationship between RDI and ASD diagnosis among individuals with LI was investigated for each language assessment.

Results
Although standard scores were unable to distinguish the LI-only and ASD/ASD + LI groups, the ASD/ASD + LI groups had higher RDI scores compared to LI-only group across all measures of expressive, pragmatic, and metalinguistic language. RDI was positively correlated with quantitative ASD traits across all subgroups and was an effective predictor of ASD diagnosis among individuals with LI.

Conclusions
The RDI is an effective quantitative metric of developmental deviance/difference that correlates with ASD traits, supporting previous associations between ASD and non-sequential skill acquisition. The RDI can be adapted to other clinical measures to investigate the degree of difference that is not captured by standard performance summary scores.