bluuebunny/crossref_metadata_2025_split huggingface dataset:
Natural History of Recurrent Alcohol‐Related Cirrhosis After Liver Transplantation: Fast and Furious
Authors: Erard‐Poinsot Domitille , Dharancy Sébastien , Hilleret Marie‐Noëlle , Faure Stéphanie , Lamblin Géraldine , Chambon‐Augoyard Christine , Donnadieu‐Rigole Hélène , Lassailly Guillaume , Boillot Olivier , Ursic‐Bedoya José , Guillaud Olivier , Leroy Vincent , Pageaux Georges‐Philippe , Dumortier Jérôme 
Published: September 2019

Alcohol‐related liver disease (ALD) is one of the main indications for liver transplantation (LT). Severe alcohol relapse can rapidly lead to recurrent alcohol‐related cirrhosis (RAC) for the graft. The aim of this study was to describe the natural history of RAC and the overall survival after LT and after an RAC diagnosis. From 1992 to 2012, 812 patients underwent primary LT for ALD in 5 French transplant centers. All patients with severe alcohol relapse and an RAC diagnosis on the graft were included. The diagnosis of cirrhosis was based on the analysis of liver biopsy or on the association of clinical, biological, radiological, and/or endoscopic features of cirrhosis. RAC was diagnosed in 57/162 patients (35.2%) with severe alcohol relapse, and 31 (54.4%) of those patients had at least 1 episode of liver decompensation. The main types of decompensation were ascites (70.9%), jaundice (58.0%), and hepatic encephalopathy (9.6%). The cumulative probability of decompensation was 23.8% at 5 years, 50.1% at 10 years, and 69.9% at 15 years after LT. During the follow‐up, 36 (63.2%) patients died, the main cause of death being liver failure (61.1%). After diagnosis of cirrhosis, the survival rate was 66.3% at 1 year, 37.8% at 5 years, and 20.6% at 10 years. In conclusion, RAC is associated with a high risk of liver decompensation and a poor prognosis. Prevention of severe alcohol relapse after LT is a major goal to improve patient survival.
Hypotrichosis with juvenile macular dystrophy: Combination of whole‐genome sequencing and genome‐wide homozygosity mapping identifies a large deletion in CDH3 initially undetected by whole‐exome sequencing—A lesson from next‐generation sequencing
Authors: Saeidian Amir Hossein , Vahidnezhad Hassan , Youssefian Leila , Sotudeh Soheila , Sargazi Meisam , Zeinali Sirous , Uitto Jouni 
Published: September 2019

AbstractBackgroundHypotrichosis with juvenile macular dystrophy (HJMD) is an autosomal recessive disorder characterized by abnormal growth of scalp hair and juvenile macular degeneration leading to blindness. We have explored the genetic basis of HJMD in a large consanguineous family with 12 affected patients, 1–76 years of age, with characteristic phenotypes.MethodsWe first applied genome‐wide homozygosity mapping to 10 affected individuals for linkage analysis to identify the genomic region of the defective gene. All affected individuals shared a 7.2 Mb region of homozygosity on chromosome 16q21‐22.3, which harbored 298 genes, including CDH3, previously associated with HJMD. However, whole‐exome sequencing (WES) failed to identify the causative mutation in CDH3.ResultsFurther investigation revealed a missense variant in a gene closely linked to CDH3 (1.4 Mb distance: FHOD1: c.1306A>G, p.Arg436Gly). This variant was homozygous in all affected individuals and heterozygous in 18 out of 19 obligate carriers. While this variant was found by bioinformatics predictions to be likely pathogenic, a knock‐in mouse for this variant, made by the CRISPR/Cas, showed no disease phenotype. However, using whole‐genome sequencing (WGS), we were able to identify a novel Alu recombination‐mediated deletion in CDH3:c.del161‐811_246 + 1,044.ConclusionWGS was able to identify a deep intronic deletion mutation, not detected by WES.
Novel ELN mutation in a Japanese family with a severe form of supravalvular aortic stenosis
Authors: Sugiyama Kaori , Horigome Hitoshi , Lin Lisheng , Murakami Takashi , Shiono Junko , Yamashiro Yoshito , Matsuura Hiroyuki , Yoda Hitoshi , Yanagisawa Hiromi 
Published: September 2019

AbstractBackgroundSupravalvular aortic stenosis (SVAS) is one of the congenital cardiovascular diseases characterized by stenosis of the aorta. The stenotic lesions occur anywhere above the aortic valve in the aortic tree as well as pulmonary arteries and eventually leads to circulatory failure. The disease gene has been identified on the elastin gene (ELN) and two types of SVAS have been categorized; a familial type and an isolated type with the de novo mutation.MethodsFluorescent In situ hybridization (FISH) analysis and gene sequencing were performed in a two‐generation family in which severe form of SVAS was diagnosed.ResultsNone of the patients tested showed microdeletion of ELN, LIMK1, and D7S613. A novel nonsense mutation of ELN (c.160G>T (p.(Gly54*)), RNA not analyzed) was found in exon 3 in three members; two of them died suddenly due to rapid progression of SVAS with possible arrhythmia in early infancy. A point mutation in the 5’ untranslated region, which was previously suggested to be associated with SVAS, did not co‐segregate with the SVAS phenotype and found to be SNPs.ConclusionOur report shows a broad spectrum of clinical features in family members sharing the identical mutations, suggesting a potential contribution of modifier gene(s) or interactions with environmental factors.
Bariatric Surgery Among Medicare Subgroups: Short‐ and Long‐Term Outcomes
Authors: Walker Elizaveta , Elman Miriam , Takemoto Erin E. , Fennern Erin , Mitchell James E. , Pories Walter J. , Ahmed Bestoun , Pomp Alfons , Wolfe Bruce M. 
Published: September 2019

ObjectiveThis study sought to examine weight change, postoperative adverse events, and related outcomes of interest among age‐qualified (AQ) and disability‐qualified (DQ) Medicare recipients compared with non‐Medicare (NM) patients undergoing an initial bariatric procedure.MethodsThe Longitudinal Assessment of Bariatric Surgery (LABS‐2) is an observational cohort study of 2,458 adults who underwent Roux‐en‐Y gastric bypass (RYGB) or laparoscopic adjustable gastric banding (LAGB) bariatric surgery. Weight, percentage body fat, functional status, and comorbidities, as well as postoperative adverse events, were assessed at baseline and annually for 5 years. The 1,943 participants who reported insurance type were categorized into the following groups: AQ, DQ, or NM.ResultsThe median preoperative BMI ranged from 45 to 48 kg/m2 across groups. For RYGB, 5‐year BMI loss was approximately 30% for all groups, and for LAGB, BMI loss was 12% to 15%. Diabetes remission after 5 years was also similar across groups within procedure types (RYGB: 33%‐40%; LAGB: 13%‐19%). The frequency of adverse events after RYGB ranged from 4.1% for NM participants to 6.7% for DQ participants. After LAGB, there were no adverse events for the AQ group, whereas 3% of DQ participants and 1.8% of NM participants had at least one adverse event.ConclusionsMedicare participants experienced substantial BMI loss and diabetes remission, with a frequency of adverse events similar to that of NM participants.
Synapse impairment associated with enhanced apoptosis in post‐traumatic stress disorder
Authors: Chen Xinzhao , Jiang Yifan , Wang Jiayu , Liu Yishu , Xiao Menglei , Song Congshan , Bai Yu , Yinuo Han Nancy , Han Fang 
Published: September 2019

AbstractSynapse impairment is associated with post‐traumatic stress disorder (PTSD), which is characterized by enhanced apoptosis in the hippocampus, amygdala, and other brain regions. However, there are no detailed studies on the relationship between apoptosis and synaptic connectivity in PTSD. In this review, we discuss results from various studies describing the synaptic changes observed in the PTSD brain. A decreased number of dendrites/spines or increased number of immature spines in the hippocampus, medial prefrontal cortex, and other brain regions has been reported. Studies on axon guidance, myelination, and the cytoskeleton suggest that PTSD may involve axon overgrowth and overbranching. Apoptosis affects synapse formation; low levels of caspase maintain the balance between growth cone attraction and repulsion and inhibit axon elongation. PTSD enhances neuronal apoptosis through caspase activation, which disrupts the balance between growth cone attraction and repulsion and alters growth cone trajectory, leading to axon mistargeting. Meanwhile, caspase activation induces dendritic pruning and dendrite degeneration. These events contribute to the formation of fewer and aberrant synapses, which is associated with enhanced apoptosis in PTSD.
Recent advances in traumatic brain injury
Authors: Khellaf Abdelhakim , Khan Danyal Zaman , Helmy Adel 
Published: September 2019

Abstract
Traumatic brain injury (TBI) is the most common cause of death and disability in those aged under 40 years in the UK. Higher rates of morbidity and mortality are seen in low-income and middle-income countries making it a global health challenge. There has been a secular trend towards reduced incidence of severe TBI in the first world, driven by public health interventions such as seatbelt legislation, helmet use, and workplace health and safety regulations. This has paralleled improved outcomes following TBI delivered in a large part by the widespread establishment of specialised neurointensive care. This update will focus on three key areas of advances in TBI management and research in moderate and severe TBI: refining neurointensive care protocolized therapies, the recent evidence base for decompressive craniectomy and novel pharmacological therapies. In each section, we review the developing evidence base as well as exploring future trajectories of TBI research.
Erythropoietic responses to a series of repeated maximal dynamic and static apnoeas in elite and non-breath-hold divers
Authors: Elia Antonis , Barlow Matthew J. , Deighton Kevin , Wilson Oliver J. , O’Hara John P. 
Published: September 2019

Abstract

Purpose
Serum erythropoietin (EPO) concentration is increased following static apnoea-induced hypoxia. However, the acute erythropoietic responses to a series of dynamic apnoeas in non-divers (ND) or elite breath-hold divers (EBHD) are unknown.

Methods
Participants were stratified into EBHD (n = 8), ND (n = 10) and control (n = 8) groups. On two separate occasions, EBHD and ND performed a series of five maximal dynamic apnoeas (DYN) or two sets of five maximal static apnoeas (STA). Control performed a static eupnoeic (STE) protocol to control against any effects of water immersion and diurnal variation on EPO. Peripheral oxygen saturation (SpO2) levels were monitored up to 30 s post each maximal effort. Blood samples were collected at 30, 90, and 180 min after each protocol for EPO, haemoglobin and haematocrit concentrations.

Results
No between group differences were observed at baseline (p > 0.05). For EBHD and ND, mean end-apnoea SpO2 was lower in DYN (EBHD, 62 ± 10%, p = 0.024; ND, 85 ± 6%; p = 0.020) than STA (EBHD, 76 ± 7%; ND, 96 ± 1%) and control (98 ± 1%) protocols. EBHD attained lower end-apnoeic SpO2 during DYN and STA than ND (p < 0.001). Serum EPO increased from baseline following the DYN protocol in EBHD only (EBHD, p < 0.001; ND, p = 0.622). EBHD EPO increased from baseline (6.85 ± 0.9mlU/mL) by 60% at 30 min (10.82 ± 2.5mlU/mL, p = 0.017) and 63% at 180 min (10.87 ± 2.1mlU/mL, p = 0.024). Serum EPO did not change after the STA (EBHD, p = 0.534; ND, p = 0.850) and STE (p = 0.056) protocols. There was a significant negative correlation (r = − 0.49, p = 0.003) between end-apnoeic SpO2 and peak post-apnoeic serum EPO concentrations.

Conclusions
The novel findings demonstrate that circulating EPO is only increased after DYN in EBHD. This may relate to the greater hypoxemia achieved by EBHD during the DYN.
The functional microscopic neuroanatomy of the human subthalamic nucleus
Authors: Alkemade Anneke , de Hollander Gilles , Miletic Steven , Keuken Max C. , Balesar Rawien , de Boer Onno , Swaab Dick F. , Forstmann Birte U. 
Published: September 2019

AbstractThe subthalamic nucleus (STN) is successfully used as a surgical target for deep brain stimulation in the treatment of movement disorders. Interestingly, the internal structure of the STN is still incompletely understood. The objective of the present study was to investigate three-dimensional (3D) immunoreactivity patterns for 12 individual protein markers for GABA-ergic, serotonergic, dopaminergic as well as glutamatergic signaling. We analyzed the immunoreactivity using optical densities and created a 3D reconstruction of seven postmortem human STNs. Quantitative modeling of the reconstructed 3D immunoreactivity patterns revealed that the applied protein markers show a gradient distribution in the STN. These gradients were predominantly organized along the ventromedial to dorsolateral axis of the STN. The results are of particular interest in view of the theoretical underpinning for surgical targeting, which is based on a tripartite distribution of cognitive, limbic and motor function in the STN.
Comparative morphology and allometry of select extant cryptodiran turtle kidneys
Authors: Thigpen Christopher , Best Logan , Camarata Troy 
Published: September 2019

AbstractReptile, avian, and mammalian species all possess a metanephric kidney to maintain fluid homeostasis. The physiology of the kidney is intimately related to tissue organization and gross morphology, which is dependent upon organ size, animal habitat, and body plan. Reptiles have significant variations in body plan and as a result have differences in visceral organ placement and morphology. One organ that appears to show great morphological variation is the reptilian kidney found in Crocodylia, Testudines, and Squamata (Sauria and Ophidia). However, limited research has been conducted to evaluate and compare kidney morphology in reptiles and more specifically, in turtles. Here we have examined multiple cryptodiran turtle species from the families Chelydridae, Emydidae, Kinosternidae, and Trionychidae. Detailed descriptions of kidney morphology along with comparative allometry are provided. Significant differences in external renal morphology were found between and within turtle families as well as differences in scaling of kidney mass with body mass. Our study provides a foundation for understanding differences in organ development and tissue architecture as well as potential differences in physiology.
Deterministic Dynamic Matching in O(1) Update Time
Authors: Bhattacharya Sayan , Chakrabarty Deeparnab , Henzinger Monika 
Published: September 2019

Abstract
We consider the problems of maintaining an approximate maximum matching and an approximate minimum vertex cover in a dynamic graph undergoing a sequence of edge insertions/deletions. Starting with the seminal work of Onak and Rubinfeld (in: Proceedings of the ACM symposium on theory of computing (STOC), 2010), this problem has received significant attention in recent years. Very recently, extending the framework of Baswana et al. (in: Proceedings of the IEEE symposium on foundations of computer science (FOCS), 2011) , Solomon (in: Proceedings of the IEEE symposium on foundations of computer science (FOCS), 2016) gave a randomized dynamic algorithm for this problem that has an approximation ratio of 2 and an amortized update time of O(1) with high probability. This algorithm requires the assumption of an oblivious adversary, meaning that the future sequence of edge insertions/deletions in the graph cannot depend in any way on the algorithm’s past output. A natural way to remove the assumption on oblivious adversary is to give a deterministic dynamic algorithm for the same problem in O(1) update time. In this paper, we resolve this question. We present a new deterministic fully dynamic algorithm that maintains a O(1)-approximate minimum vertex cover and maximum fractional matching, with an amortized update time of O(1). Previously, the best deterministic algorithm for this problem was due to Bhattacharya et al. (in: Proceedings of the ACM-SIAM symposium on discrete algorithms (SODA), 2015); it had an approximation ratio of $$(2+\varepsilon )$$(2+ε) and an amortized update time of $$O(\log n/\varepsilon ^2)$$O(logn/ε2). Our result can be generalized to give a fully dynamic $$O(f^3)$$O(f3)-approximate algorithm with $$O(f^2)$$O(f2) amortized update time for the hypergraph vertex cover and fractional hypergraph matching problem, where every hyperedge has at most f vertices.
Expansion Speed as a Generic Measure of Spread for Alien Species
Authors: Sandvik Hanno 
Published: September 2019

Abstract
The ecological impact of alien species is a function of the area colonised. Impact assessments of alien species are thus incomplete unless they take the spatial component of invasion processes into account. This paper describes a measure, termed expansion speed, that quantifies the speed with which a species increases its spatial presence in an assessment area. It is based on the area of occupancy (AOO) and can be estimated from grid occupancies. Expansion speed is defined as the yearly increase in the radius of a coherent circle having the same area as the AOO, irrespective of whether the increase is due to natural dispersal or anthropogenic transport. Two methods for estimating expansion speed are presented: one that requires several years of spatio-temporal observation data and explicitly takes detection rates into account; and one that can be used under a situation with sparse data. Using simulations and real-world data from natural history collections, it is shown that the method provides a good fit to observational datasets. Expansion speed has several valuable properties. Being based on AOO, it is an intuitive measure; as it only requires occupancy data, it is comparatively easy to estimate; and because it is a quantitative and generic measure, it increases the testability and comparability of impact assessments of alien species.
The best wildflowers for wild bees
Authors: Nichols Rachel N. , Goulson Dave , Holland John M. 
Published: September 2019

AbstractGovernmental agri-environment schemes (AES) aim to improve pollinator abundance and diversity on farmland by sowing wildflower seed mixes. These often contain high proportions of Fabaceae, particularlyTrifolium(clovers), which are attractive to some bumblebee species, but not to most of the ~ 240 solitary bee species in the UK. Here we identify wildflowers that are attractive to a greater range of wild bee species. Forty-five wildflower species being farmed for commercial seed production on a single farm were surveyed for native bees. Bee walks were conducted through discrete wildflower areas from April until August in 2018. The results indicate that including a range of Apiaceae, Asteraceae, and Geraniaceae in seed mixes would cater for a wide diversity of bee species. A total of 14 wildflower species across nine families attracted 37 out of the 40 bee species recorded on the farm, and accounted for 99.7% of all visitations. Only two of these 14 species are included in current AES pollinator mixes. Unexpectedly, few visits were made by bumblebees toTrifoliumspp. (0.5%), despite their being considered an important food source for bumblebees, whileAnthyllis vulnerariaandGeranium pratensewere highly attractive. For solitary bees,Crepis capillaris,Sinapsis arvensis,Convolvulus arvensisandChaerophyllum temulumwere amongst the best performing species, none of which are usually included in sown flower mixes. We suggest that the standard ‘pollinator’ mixes used in AES might be updated to include some of these wildflower species, and trialled as seed mixes on farmland.
Radionuclide extraction with different ionic liquids
Authors: Scheiflinger Florian , Habibi Marzieh , Zeynolabedini Elham , Plessl Christof , Wallner Gabriele 
Published: September 2019

Abstract
10 ionic liquids based on 3 different cations and 5 anions were investigated for radionuclide extraction from aqueous solutions. While uranium and 210Po were extracted with satisfying yields irrespective of the feed solution pH, 234Th, 226Ra and 210Pb extraction yields were rather low. The contact time necessary for near to complete extraction was determined as well as the conditions for successful back-extraction. The loading capacities of the ionic liquids for uranium were very high and depended on the uranyl counter-ion. From the leaching of the ionic liquids into the aqueous phase the predominant extraction mechanisms were derived.
Rhaponticin as an anti-inflammatory component of rhubarb: a minireview of the current state of the art and prospects for future research
Authors: Kolodziejczyk-Czepas Joanna , Czepas Jan 
Published: September 2019

AbstractRhaponticin (3,3′,5-trihydroxy-4′-methoxystilbene 3-O-β-d-glucoside; synonym–rhapontin), is a stilbene compound, mainly found in various species of rhubarb (RheumL.). The aglycone, rhapontigenin, is thought to be the biologically active form of rhaponticin. As a component of rhubarb, rhaponticin may be present in the human diet both in foods and dietary supplements. Although promising reports have been published on the various activities of rhaponticin (see: antioxidant, estrogenic, antithrombotic, anticancer and anti-inflammatory actions), no comprehensive review exists of its anti-inflammatory properties. Therefore, the aim of the present work is to summarize the existing evidence of the anti-inflammatory properties of rhaponticin and provide a prospective insight into research on this stilbenoid.
Is choice blindness a case of self-ignorance?
Authors: Bortolotti Lisa , Sullivan-Bissett Ema 
Published: September 2019

AbstractWhen subject to the choice-blindness effect, an agent gives reasons for making choice B, moments after making the alternative choice A. Choice blindness has been studied in a variety of contexts, from consumer choice and aesthetic judgement to moral and political attitudes. The pervasiveness and robustness of the effect is regarded as powerful evidence of self-ignorance. Here we compare two interpretations of choice blindness. On the choice error interpretation, when the agent gives reasons she is in fact wrong about what her choice is. On the choice change interpretation, when the agent gives reasons she is right about what her choice is, but she does not realise that her choice has changed. In this paper, we spell out the implications of the two interpretations of the choice-blindness effect for self-ignorance claims and offer some reasons to prefer choice change to choice error.