bluuebunny/crossref_metadata_2025_split huggingface dataset:
Risk Factors for Major Early Adverse Events Related to Cardiac Catheterization in Children and Young Adults With Pulmonary Hypertension: An Analysis of Data From the IMPACT (Improving Adult and Congenital Treatment) Registry
Authors: O'Byrne Michael L. , Kennedy Kevin F. , Kanter Joshua P. , Berger John T. , Glatz Andrew C. 
Published: March 2018

Background

Cardiac catheterization is the gold standard for assessment and follow‐up of patients with pulmonary hypertension (
PH
). To date, there are limited data about the factors that influence the risk of catastrophic adverse events after catheterization in this population.

Methods and Results

A retrospective multicenter cohort study was performed to measure risk of catastrophic adverse outcomes after catheterization in children and young adults with
PH
and identify risk factors for these outcomes. All catheterizations in children and young adults, aged 0 to 21 years, with
PH
at hospitals submitting data to the IMPACT (Improving Adult and Congenital Treatment) registry between January 1, 2011, and December 31, 2015, were studied. Using mixed‐effects multivariable regression, we assessed the association between prespecified subject‐, procedure‐, and center‐level covariates and the risk of death, cardiac arrest, or mechanical circulatory support during or after cardiac catheterization. A total of 8111 procedures performed in 7729 subjects at 77 centers were studied. The observed risk of the composite outcome was 1.4%, and the risk of death before discharge was 5.2%. Catheterization in prematurely born neonates and nonpremature infants was associated with increased risk of catastrophic adverse event, as was precatheterization treatment with inotropes and lower systemic arterial saturation. Secondary analyses demonstrated the following: (1) increasing volumes of catheterization in patients with PH were associated with reduced risk of composite outcome (odds ratio, 0.8 per 10 procedures;
P
=0.002) and (2) increasing pulmonary vascular resistance and pulmonary artery pressures were associated with increased risk (
P<
0.0001 for both).

Conclusions

Young patients with PH are a high‐risk population for diagnostic and interventional cardiac catheterization. Hospital experience with
PH
is associated with reduced risk, independent of total catheterization case volume.
Description of three species of Eurypon Gray, 1867 (Raspailiidae: Demospongiae: Porifera) from the Western Atlantic and a name to replace the the secondary homonym Eurypon topsenti
Authors: CAVALCANTI THAYNÃ , SANTOS GEORGE GARCIA , PINHEIRO ULISSES 
Published: March 2018

Eurypon Gray, 1867 comprises 49 valid species distributed worldwide, and in an extensive bathymetric range. Three Eurypon species are known for Brazil, all endemic from the Northeast region. Here, we describe three new species of Eurypon. Two of which are recorded from shallow waters (down to 100 m) off Pernambuco and Paraíba States, and one species is from deep waters (157 m) off Rio Grande do Norte State. Eurypon oxychaetum sp. nov. has large subtylostyles (1025–2125 µm, length), styles, two categories of acanthostyles and oxychaetes; Eurypon potiguaris sp. nov. has large tylostyles (1000–2315 µm, length), two categories of acanthostyles, and thin oxeas; Eurypon verticillatum sp. nov. is a blue sponge with exclusive verticillate acanthostyles. The new species were compared with all other Atlantic species of the genus. A replacement name for the secondary homonym Eurypon topsenti is proposed: Eurypon pulitzeri nom. nov. The presence of verticillate acanthostyles and oxychaetes spicules are reported for the first time in Table 1 genus.
ENSO Influence on TRMM Tropical Oceanic Precipitation Characteristics and Rain Rates
Authors: Henderson David S. , Kummerow Christian D. , Berg Wesley 
Published: March 2018

AbstractDiscrepancies between Tropical Rainfall Measuring Mission (TRMM) Microwave Imager (TMI) and Precipitation Radar (PR) oceanic rainfall retrievals are prevalent between El Niño and La Niña conditions with TMI exhibiting systematic shifts in precipitation. To investigate the causality of this relationship, this paper focuses on the evolution of precipitation organization between El Niño and La Niña and their impacts on TRMM precipitation. The results indicate that discrepancies are related to shifts from isolated deep convection during La Niña toward organized precipitation during El Niño with the largest variability occurring in the Pacific basins. During El Niño, organized systems are more frequent, have increased areal coverage of stratiform rainfall, and penetrate deeper into the troposphere compared to La Niña. The increased stratiform raining fraction leads to larger increases in TMI rain rates than PR rain rate retrievals. Reanalysis and water vapor data from the Atmospheric Infrared Sounder (AIRS) indicate that organized systems are aided by midtropospheric moisture increases accompanied by increased convective frequency. During La Niña, tropical rainfall is dominated by isolated deep convection due to drier midtropospheric conditions and strong mid- and upper-level zonal wind shear. To examine tropical rainfall–sea surface temperature relations, regime-based bias corrections derived using ground validation (GV) measurements are applied to the TRMM rain estimates. The robust connection with GV-derived biases and oceanic precipitation leads to a reduction in TMI-PR regional differences and tropics-wide precipitation anomalies. The improved agreement between PR and TMI estimates yields positive responses of precipitation to tropical SSTs of 10% °C−1 and 17% °C−1, respectively, consistent with 15% °C−1 from the Global Precipitation Climatology Project (GPCP).
Predicting Monsoon Intraseasonal Precipitation using a Low-Order Nonlinear Stochastic Model
Authors: Chen Nan , Majda Andrew J. , Sabeerali C. T. , Ajayamohan R. S. 
Published: March 2018

Abstract
The authors assess the predictability of large-scale monsoon intraseasonal oscillations (MISOs) as measured by precipitation. An advanced nonlinear data analysis technique, nonlinear Laplacian spectral analysis (NLSA), is applied to the daily precipitation data, resulting in two spatial modes associated with the MISO. The large-scale MISO patterns are predicted in two steps. First, a physics-constrained low-order nonlinear stochastic model is developed to predict the highly intermittent time series of these two MISO modes. The model involves two observed MISO variables and two hidden variables that characterize the strong intermittency and random oscillations in the MISO time series. It is shown that the precipitation MISO indices can be skillfully predicted from 20 to 50 days in advance. Second, an effective and practical spatiotemporal reconstruction algorithm is designed, which overcomes the fundamental difficulty in most data decomposition techniques with lagged embedding that requires extra information in the future beyond the predicted range of the time series. The predicted spatiotemporal patterns often have comparable skill to the MISO indices. One of the main advantages of the proposed model is that a short (3 year) training period is sufficient to describe the essential characteristics of the MISO and retain skillful predictions. In addition, both model statistics and prediction skill indicate that outgoing longwave radiation is an accurate proxy for precipitation in describing the MISO. Notably, the length of the lagged embedding window used in NLSA is crucial in capturing the main features and assessing the predictability of MISOs.
Ridges, Seamounts, Troughs, and Bowls: Topographic Control of the Dianeutral Circulation in the Abyssal Ocean
Authors: Holmes Ryan M. , de Lavergne Casimir , McDougall Trevor J. 
Published: March 2018

AbstractIn situ observations obtained over the last several decades have shown that the intensity of turbulent mixing in the abyssal ocean is enhanced toward the seafloor. Consequently, a new paradigm has emerged whereby dianeutral downwelling dominates in the ocean interior and dianeutral upwelling only occurs within thin bottom boundary layers. This study shows that when mixing is bottom intensified the net abyssal dianeutral transports and the stratification can depend on subtle features of the seafloor geometry. Under an assumption of depth-independent net dianeutral upwelling, small changes in the curvature of the seafloor can result in interior stratification that is bottom intensified, uniform, or surface intensified. Further, when the net dianeutral transport is allowed to vary in the vertical, changes in the seafloor slope and bathymetric contour length with height can drive lateral exchange between the boundary layer and interior, with particularly strong lateral outflows predicted at the crests of midocean ridges. Finally, using a realistic neutral density climatology the authors suggest that the increase in the perimeter of abyssal neutral density surfaces with height drives much of the dianeutral upwelling at depths greater than 4 km, while the increase in the slope of the seafloor at shallower depths acts to oppose upwelling. These results add to a growing body of literature highlighting the key control of seafloor geometry on the abyssal overturning circulation.
Evaluation of the NCEP Climate Forecast System and Its Downscaling for Seasonal Rainfall Prediction over Vietnam
Authors: Phan-Van Tan , Nguyen-Xuan Thanh , Van Nguyen Hiep , Laux Patrick , Pham-Thanh Ha , Ngo-Duc Thanh 
Published: March 2018

Abstract
This study investigates the ability to apply National Centers for Environmental Prediction (NCEP) Climate Forecast System (CFS) products and their downscaling by using the Regional Climate Model version 4.2 (RegCM4.2) on seasonal rainfall forecasts over Vietnam. First, the CFS hindcasts (CFS_Rfc) from 1982 to 2009 are used to assess the ability of the CFS to predict the overall circulation and precipitation patterns at forecast lead times of up to 6 months. Second, the operational CFS forecasts (CFS_Ope) and its RegCM4.2 downscaling (RegCM_CFS) for the period 2012–14 are used to derive seasonal rainfall forecasts over Vietnam. The CFS_Rfc and CFS_Ope are validated against the ECMWF interim reanalysis, the Global Precipitation Climatology Centre (GPCC) analyzed rainfall, and observations from 150 meteorological stations across Vietnam. The results show that the CFS_Rfc can capture the seasonal variability of the Asian monsoon circulation and rainfall distribution. The higher-resolution RegCM_CFS product is advantageous over the raw CFS in specific climatic subregions during the transitional, dry, and rainy seasons, particularly in the northern part of Vietnam in January and in the country’s central highlands during July.
What about the men? Gender parity in occupational therapy
Authors: Beagan Brenda L. , Fredericks Erin 
Published: March 2018

Background. Gender parity is frequently raised as an equity issue in occupational therapy, with strategies proposed to recruit more men. Purpose. This article explores whether this is a legitimate equity concern. Key Issues. Most employment is gender segregated; when gender balances change, the field either re-genders feminine or creates gender-segregated internal divisions. Men avoid feminized jobs because they pay less and hold less social status. They are a “step down” for men. In such jobs, men are disproportionately pushed into management positions, with better pay, more prestige, and less hands-on care. Equity issues concern structural barriers to success in particular employment fields. Though they may feel discomfort in a feminized field, men do not face structural barriers in occupational therapy. Implications. Broader challenges to traditional gender norms are needed, but there is no evidence that gender parity is an equity concern or that recruitment targeting masculinity would make a difference.
Rhythms of the Heart: An interprofessional community health collaboration to increase cardiovascular health knowledge
Authors: Omelchenko Kira L , Hall Carrie A , Gainey Melissa E , Olson Gayle E 
Published: March 2018

Objectives: Cardiovascular health continues to be a leading cause of morbidity and mortality in the USA. An interprofessional collaborative team comprising university faculty and undergraduate students developed and presented a community outreach event to provide education and health screening to a diverse group of local residents. Design: An event entitled Rhythms of the Heart was planned and implemented to reach community members. Setting: The event took place on the campus of a private college in Central Florida, USA. Methods: Clinical services, including health screening for blood pressure and body fat, were provided, along with information on the benefits of smoking cessation, physical activity, weight management, healthy diet alternatives and stress reduction. Local community resources and educational materials were supplied to event participants. Results: The event attracted approximately 275 guests. An analysis of feedback from attendees indicated a greater appreciation of music to enhance one’s understanding of cardiovascular health. Students and attendees perceived the Rhythms of the Heart concert as ‘smart and creative’, ‘cleverly conceived’ and ‘well thought out’. Conclusion: This interprofessional outreach event provided a novel means by which to undertake community education and health screening.
Addition of an educational programme for primary caregivers to rehabilitation improves self-care and mobility in children with cerebral palsy: a randomized controlled trial
Authors: Saquetto Micheli Bernardone , de Santana Bispo Adriana , da Silva Barreto Camila , Gonçalves Katiuce Almeida , Queiroz Rodrigo Santos , da Silva Cássio Magalhães , Gomes Neto Mansueto 
Published: March 2018

Objective: To assess whether the addition of an education programme for primary caregivers to rehabilitation improves daily functioning in children with cerebral palsy. Design: A randomized, single-blind, controlled study. Setting: This study was conducted in a rehabilitation centre in Salvador, Brazil. Participants: A total of 63 boys and girls with cerebral palsy, at 1–12 years of age, with Gross Motor Function Classification Systems I–V, were randomly assigned to two groups: educational programme for primary caregivers and conventional rehabilitation ( n = 29) or conventional rehabilitation alone ( n = 31). Intervention: Each group received 12 sessions of 30 minutes of conventional rehabilitation and 12 sessions of 45 minutes to intervention group. Measurements: Gross Motor Function Classification System, Gross Motor Function Measure and daily functioning with the Pediatric Evaluation of Disability Inventory were assessed by a blinded assessor. The clinical outcomes were obtained at the completion of treatment (12 weeks). Results: Of the 63 patients included, 60 (mean ± SD age: 4.6 ± 2.74 years) completed the protocol. The combined education and rehabilitation, as compared with conventional rehabilitation alone, yielded significantly greater benefit in the self-care domain of the Functional Skills Scale (mean change 1.74 versus 5; P = 0.001), self-care (mean change 5.52 versus 13.99; P = 0.017) and the mobility domain of the Caregiver Assistance Scale of Pediatric Evaluation of Disability Inventory (mean change 0.87 versus 17.88; P = 0.002). Conclusion: Self-care and mobility improved in children with cerebral palsy with the addition to conventional rehabilitation of an educational programme for primary caregivers.
Who cares for the carers at hospital discharge at the end of life? A qualitative study of current practice in discharge planning and the potential value of using The Carer Support Needs Assessment Tool (CSNAT) Approach
Authors: Ewing Gail , Austin Lynn , Jones Debra , Grande Gunn 
Published: March 2018

Background: Carer factors prevent patients achieving timely and appropriate hospital discharge. There is a lack of research into interventions to support carers at hospital discharge. Aim: To explore whether and how family carers are currently supported during patient discharge at end of life; to assess perceived benefits, acceptability and feasibility of using The Carer Support Needs Assessment Tool (CSNAT) Approach in the hospital setting to support carers. Design: Qualitative. Setting/participants: Three National Health Service Trusts in England: focus groups with 40 hospital and community-based practitioners and 22 carer interviews about experiences of carer support during hospital discharge and views of The CSNAT Approach. Two workshops brought together 14 practitioners and five carers to discuss implementation issues. Framework analysis was conducted. Results: Current barriers to supporting carers at hospital discharge were an organisational focus on patients’ needs, what practitioners perceived as carers’ often ‘unrealistic expectations’ of end-of-life caregiving at home and lack of awareness of patients’ end-of-life situation. The CSNAT Approach was viewed as enabling carer support and addressing difficulties of discussing the realities of supporting someone at home towards end of life. Implementation in hospital required organisational considerations of practitioner workload and training. To enhance carer support, a two-stage process of assessment and support (hospital with community follow-up) was suggested using the CSNAT as a carer-held record to manage the transition. Conclusion: This study identifies a novel intervention, which expands the focus of discharge planning to include assessment of carers’ support needs at transition, potentially preventing breakdown of care at home and patient readmissions to hospital.
Liraglutide prevents metabolic side-effects and improves recognition and working memory during antipsychotic treatment in rats
Authors: Babic Ilijana , Gorak Ashleigh , Engel Martin , Sellers Dominic , Else Paul , Osborne Ashleigh L , Pai Nagesh , Huang Xu-Feng , Nealon Jessica , Weston-Green Katrina 
Published: March 2018

Background: Antipsychotic drugs (APDs), olanzapine and clozapine, do not effectively address the cognitive symptoms of schizophrenia and can cause serious metabolic side-effects. Liraglutide is a synthetic glucagon-like peptide-1 (GLP-1) receptor agonist with anti-obesity and neuroprotective properties. The aim of this study was to examine whether liraglutide prevents weight gain/hyperglycaemia side-effects and cognitive deficits when co-administered from the commencement of olanzapine and clozapine treatment. Methods: Rats were administered olanzapine (2 mg/kg, three times daily (t.i.d.)), clozapine (12 mg/kg, t.i.d.), liraglutide (0.2 mg/kg, twice daily (b.i.d.)), olanzapine + liraglutide co-treatment, clozapine + liraglutide co-treatment or vehicle (Control) ( n = 12/group, 6 weeks). Recognition and working memory were examined using Novel Object Recognition (NOR) and T-Maze tests. Body weight, food intake, adiposity, locomotor activity and glucose tolerance were examined. Results: Liraglutide co-treatment prevented olanzapine- and clozapine-induced reductions in the NOR test discrimination ratio ( p < 0.001). Olanzapine, but not clozapine, reduced correct entries in the T-Maze test ( p < 0.05 versus Control) while liraglutide prevented this deficit. Liraglutide reduced olanzapine-induced weight gain and adiposity. Olanzapine significantly decreased voluntary locomotor activity and liraglutide co-treatment partially reversed this effect. Liraglutide improved clozapine-induced glucose intolerance. Conclusion: Liraglutide co-treatment improved aspects of cognition, prevented obesity side-effects of olanzapine, and the hyperglycaemia caused by clozapine, when administered from the start of APD treatment. The results demonstrate a potential treatment for individuals at a high risk of experiencing adverse effects of APDs.
Dose reduction of risperidone and olanzapine can improve cognitive function and negative symptoms in stable schizophrenic patients: A single-blinded, 52-week, randomized controlled study
Authors: Zhou Yanling , Li Guannan , Li Dan , Cui Hongmei , Ning Yuping 
Published: March 2018

Background: The long-term effects of dose reduction of atypical antipsychotics on cognitive function and symptomatology in stable patients with schizophrenia remain unclear. We sought to determine the change in cognitive function and symptomatology after reducing risperidone or olanzapine dosage in stable schizophrenic patients. Methods: Seventy-five stabilized schizophrenic patients prescribed risperidone (≥4 mg/day) or olanzapine (≥10 mg/day) were randomly divided into a dose-reduction group ( n=37) and a maintenance group ( n=38). For the dose-reduction group, the dose of antipsychotics was reduced by 50%; for the maintenance group, the dose remained unchanged throughout the whole study. The Positive and Negative Syndrome Scale, Negative Symptom Assessment-16, Rating Scale for Extrapyramidal Side Effects, and Measurement and Treatment Research to Improve Cognition in Schizophrenia (MATRICS) Consensus Cognitive Battery were measured at baseline, 12, 28, and 52 weeks. Linear mixed models were performed to compare the Positive and Negative Syndrome Scale, Negative Symptom Assessment-16, Rating Scale for Extrapyramidal Side Effects and MATRICS Consensus Cognitive Battery scores between groups. Results: The linear mixed model showed significant time by group interactions on the Positive and Negative Syndrome Scale negative symptoms, Negative Symptom Assessment-16, Rating Scale for Extrapyramidal Side Effects, speed of processing, attention/vigilance, working memory and total score of MATRICS Consensus Cognitive Battery (all p<0.05). Post hoc analyses showed significant improvement in Positive and Negative Syndrome Scale negative subscale, Negative Symptom Assessment-16, Rating Scale for Extrapyramidal Side Effects, speed of processing, working memory and total score of MATRICS Consensus Cognitive Battery for the dose reduction group compared with those for the maintenance group (all p<0.05). Conclusions: This study indicated that a risperidone or olanzapine dose reduction of 50% may not lead to more severe symptomatology but can improve speed of processing, working memory and negative symptoms in patients with stabilized schizophrenia.
19 mm Sized Bileaflet Valve Prostheses’ flow Field Investigated by Bidimensional Laser Doppler Anemometry (part I: Velocity Profiles)
Authors: Barbaro V. , Grigioni M. , Daniele C. , D'avenio G. , Boccanera G. 
Published: March 2018

The investigation of the flow field downstream of a cardiac valve prosthesis is a well established task. In particular turbulence generation is of interest if damage to blood costituents is to be assessed. Several prosthetic valve flow studies are available in literature but they generally concern large-sized prostheses. The FDA draft guidance requires the study of the maximum Reynolds number conditions for a cardiac valve model to assess the worst case in turbulence by chosing both the minimum valve diameter and a high cardiac output value as protocol set up. Within the framework of a national research project regarding the characterization of cardiovascular endoprostheses, the Laboratory of Biomedical Engineering is currently conducting an in-depth study of turbulence generated downstream of bileaflet cardiac valves. Four models of 19 mm sized bileaflet valve prostheses, namely St Jude Medical HP, Edwards Tekna, Sorin Bicarbon, and CarboMedics, were studied in aortic position. The prostheses were selected for the nominal annulus diameter reported by the manufacturers without any assessment of the valve sizing method. The hemodynamic function was investigated using a bidimensional LDA system. Results concern velocity profiles during the peak flow systolic phase, at high cardiac output regime, highlighting the different flow field features downstream of the four small-sized cardiac valves.