bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fertility counseling before cancer treatment and subsequent reproductive concerns among female adolescent and young adult cancer survivors
Authors: Young Katie , Shliakhtsitsava Ksenya , Natarajan Loki , Myers Emily , Dietz Andrew C. , Gorman Jessica R. , Martínez María Elena , Whitcomb Brian W. , Su H. Irene 
Published: November 2018

BackgroundFertility counseling before cancer treatment has been advocated by clinical guidelines, though little is known about its long‐term impact on the unique reproductive concerns of female adolescent and young adult (AYA) cancer survivors. The goal of this study was to measure the association between fertility counseling by fertility specialists before cancer treatment and subsequent reproductive concerns.MethodA cross‐sectional analysis was performed among 747 AYA survivors aged 18‐40 years who had been recruited from cancer registries and physician and advocacy group referrals between 2015 and 2017. Participants self‐reported information on past fertility counseling at cancer diagnosis, cancer type and treatment, and current reproductive concerns, as measured using the multidimensional Reproductive Concerns After Cancer scale. Multivariable log‐binomial regression models tested associations between fertility counseling and reproductive concerns.ResultsThe mean age of the cohort was 33.0 years (standard deviation, 5.1 years), and the mean period since diagnosis was 7.7 years (standard deviation, 5.0 years). Seventy‐three percent of participants were white, and 24% were Hispanic. Fertility counseling was reported by 19% of survivors; moderate to high overall reproductive concerns were reported by 44% of participants. In adjusted analysis, fertility counseling was significantly associated with moderate to high reproductive concerns (risk ratio, 1.22; 95% confidence interval, 1.02‐1.45) and not modified by exposure to fertility‐threatening treatments (Pinteraction = .23).ConclusionA large proportion of AYA cancer survivors across cancer types and treatment exposures reported moderate to high reproductive concerns, suggesting that there is a need to address these cancer‐specific reproductive health concerns after treatment. Higher concerns, even with counseling, suggests the need to improve the quality of fertility counseling throughout the cancer continuum.
Analyzing the impact of news trends on research publications and scientific collaboration networks
Authors: J P Nivash , Babu L.D. Dhinesh 
Published: November 2018

SummaryScientific collaboration plays a vital role in generating novel ideas and innovative research progress among the researchers. Similarly, news diffusion also has an important role among the research communities. Though the collaboration networks have made an impact in scientific activities and attracted the attention of scientific communities, no work so far analyzed the cause which can determine the future research publications. The objective of this paper is to study influence of news trends on scientific collaboration and research publications. For this purpose, we have collected the top technological news trends and applied the LDA model to identify top research keywords from the articles. The results show that the news trends play a significant role on scientific collaborations and innovative research progress. It is found that the researchers identify their research gap, make future collaborations and does interdisciplinary research. Our results highlight the important role of diffusion of news, which influence the young researchers to generate novel ideas and tend to collaborate more with different scientific communities.
National population‐based data on the incidence, prevalence, and psychiatric comorbidity of eating disorders in Taiwanese adolescents and young adults
Authors: Tsai Meng‐Che , Gan Shu‐Ting , Lee Chih‐Ting , Liang Yi‐Lin , Lee Lan‐Ting , Lin Sheng‐Hsiang 
Published: November 2018

AbstractObjectiveNationwide data on eating disorders (EDs) among East Asian populations are scarce. This study aimed to estimate the prevalence, incidence, and psychiatric comorbidities of EDs in Taiwan.MethodDrawing from the National Health Research Institute database, we identified the study subjects aged 11–34 years who received an ED diagnosis during ambulatory visits or hospitalization from 2001 to 2012. We analyzed the subjects by age and gender. Diagnoses for comorbid psychiatric disorders were entered in the analysis only if they occurred within 1 year before or after the ED diagnosis date. Rates were age‐ and sex‐adjusted to the average population within the study period.ResultsThe estimated mean annual incidence was approximately 11.11 (95% CI 10.51–11.72) per 100,000 residents, and the 1 year prevalence was 20.87 (95% CI 20.05–21.70) per 100,000 residents, with evidence of female predominance (female/male ratio = 10.95, 95% CI = 8.97–13.36). Incidence and prevalence peaked at ages 20–24 in females and at ages 25–29 in males. Both rates nearly doubled within a decade. Specifically, the anorexia nervosa trend recently stabilized in females and decreased in males, while that for bulimia nervosa increased in both females and males. The most common comorbid diagnoses were anxiety (53%) and major depressive disorders (22%).DiscussionThe incidence and prevalence of EDs were lower in Taiwan than in Western countries. However, these rates were rapidly rising, notably in males. The majority of Taiwanese ED patients also received a diagnosis for various psychiatric comorbidities, a finding worthy of clinical attention.
Far infrared‐assisted removal of extraction solvent for capillary electrophoretic determination of the bioactive constituents in Plumula Nelumbinis
Authors: Wan Danjing , Han Yu , Li Farui , Mao Hua , Chen Gang 
Published: November 2018

AbstractFar infrared radiation was employed in the rapid removal of the solvents in the extracts of Plumula Nelumbinis and standard mixture solutions to prevent the interference of the solvent peaks toward their capillary electrophoretic measurements. The sample solutions in small vials were exposed to far infrared ray at 60°C for 3 min to remove solvent. The dried samples in the vials were each dissolved into running buffer with the aid of ultrasonication for capillary electrophoresis analysis. The far infrared‐assisted solvent removal approach was sucessfully applied in the rapid determination of neferine, liensinine, isoliensinine, rutin and hyperoside in Plumula Nelumbinis. The five analytes could be well separated within 12 min in a 40 cm long fused silica capillary at a separation voltage of 12 kV in a 50 mM borate buffer (pH 9.2). The results indicated that the interferences of the solvent peaks in the capillary electropherograms of the herbal drugs were eliminated completely.
Use of surgical sealant in the prevention of pharyngocutaneous fistula after total laryngectomy
Authors: Stephenson Kate A. , Pandey Sarita , Lubbe Darlene E. , Fagan Johannes J. 
Published: November 2018

AbstractBackgroundPharyngocutaneous fistula is a major wound complication of total laryngectomy. Surgical sealants may be used to increase the strength and/or integrity of surgical repairs. The purpose of this study was to present our evaluation of the feasibility and utility of the application of sealant to the pharyngeal repair with the aim of reducing pharyngocutaneous fistula incidence.MethodsThis was a prospective single‐blind randomized controlled study; patients undergoing primary total laryngectomy for advanced carcinoma of the larynx were randomized into control and treatment (albumin‐polyaldehyde sealant applied to pharyngeal repair) groups. Relevant patient, disease, and management‐related factors were recorded.ResultsForty‐five patients were included (23 controls and 22 who received treatments). No difference in the incidence of pharyngocutaneous fistula was observed between the 2 groups. No treatment‐related complications occurred.ConclusionFeasibility of application of an albumin‐polyaldehyde surgical sealant to the pharyngeal repair was demonstrated, however, a pharyngocutaneous fistula‐preventative effect was not observed. Larger animal and clinical studies are encouraged to clarify this finding.
Public‐private partnership (PPP) development: Toward building a PPP framework for healthy eating
Authors: De Pinho Campos Katia , Cohen Joanna E. , Gastaldo Denise , Jadad Alejandro R. 
Published: November 2018

SummaryPublic‐private partnerships (PPPs) in public health have gained great attention in the global health literature over the last two decades. Evidence suggests that PPPs could contribute to mitigating complex health problems. There is, however, limited knowledge about the process and specific conditions in which PPPs for healthy eating, in particular, can be developed successfully. To address this gap, this article first summarizes the literature, and second, using qualitative content analysis, identifies factors deemed to influence the process of building PPPs for healthy eating. The literature search was undertaken in two stages. The first stage focused on PPPs in public health to understand what constitutes a PPP, and the types and characteristics of PPPs. The second stage sought empirical examples and conceptual papers related to PPPs for healthy eating to identify critical elements that could facilitate or hinder partnerships between the government and the food industry. The search yielded 38 articles on PPPs in public health and 20 on PPPs for healthy eating. The analysis generated 23 individual elements that have the potential to influence a successful process of building PPPs for healthy eating (eg, endorsement from an individual champion, equal representation from partner organizations on board committees). The analysis also yielded five factors that appeared to well‐represent the 23 individual elements of PPP formation: motivation, enablers, governance, benefits, and barriers. These results constitute an important step to understand critical factors involved in the formation of PPPs in public health and should inform additional empirical research to validate them.
Pollutant footprint analysis for wastewater management in textile dye houses processing different fabrics
Authors: Sözen Seval , Dulkadiroglu Hakan , Begum Yucel Ayse , Insel Guclu , Orhon Derin 
Published: November 2018

AbstractBACKGROUNDThis study investigated the water and pollution footprints of a dye house, which processed cotton knits, polyester (PES) knits and PES‐viscose woven fabrics. Experimental evaluation was carried out for each processing sequence. Variations in wastewater flow and quality were established as a function of the production program in the plant. A model evaluation of wastewater dynamics was performed and defined specifications of an appropriate treatment scheme.RESULTSThe plant was operated with a capacity of 4300 t year−1 of fabric, which generated a wastewater flow of 403 500 m3 year−1 and a COD load of 675 t year−1. The overall wastewater footprint of the plant was computed as 91 m3 t−1 and the COD footprint as 160 kg t−1 of fabric. Depending on the fabric type, results indicated expected changes in wastewater flow between 600 and 1750 m3 day−1; in COD load between 1470 and 2260 kg day−1 and in COD concentration between 1290 and 3400 mg L−1.CONCLUSIONA model simulation structured upon COD fractionation and related process kinetics revealed partial removal of slowly biodegradable COD, coupled with high residual COD, which would by‐pass treatment. Resulting biodegradation characteristics necessitated an extended aeration system, which could also enable partial breakdown of residual COD. Effluent COD could be reduced to 220–320 mg L−1 with this wastewater management strategy. © 2018 Society of Chemical Industry
Targeting regulation of cyclin dependent kinase 9 as a novel therapeutic strategy in synovial sarcoma
Authors: Li Xiaoyang , Seebacher Nicole A. , Xiao Tao , Hornicek Francis J. , Duan Zhenfeng 
Published: November 2018

ABSTRACTSynovial sarcomas hold a low genomic complexity, making it distinct from other types of soft‐tissue sarcomas. Many studies focused on targeting the SS18‐SSX fusion protein, which presents in over 90% of human synovial sarcomas. This protein acts as an oncogenic promoter in the tumorigenesis of synovial sarcomas, making it an ideal therapeutic target. However, to date there have been no effective strategies targeting SS18‐SSX for the treatment of synovial sarcomas. Therefore, it is an urgent need to identify alternative therapeutic targets. More recently, CDK9, a protein involved in RNA transcription regulation, has been investigated for its role in the pathogenesis of cancer. However, the expression and function of CDK9 in synovial sarcomas remains to be elucidated. In the present study, we found that CDK9 was to be largely localized to the cell nucleus, and highly expressed in all tested human synovial sarcoma cell lines and over 90% of human sarcoma tissue microarray samples. High‐CDK9 expression was associated with a poorer patient prognosis of human sarcomas. Inhibition of CDK9, with either siRNA or a CDK9 inhibitor, prevented synovial sarcoma cell growth and proliferation in a dose‐dependent manner. This was also accompanied with a reduction in the phosphorylation of RNA polymerase II and an increase in the expression of anti‐apoptotic proteins. Moreover, CDK9 inhibition decreased sarcoma cell spheroid formation and cell motility. Collectively, these findings highlight the importance of CDK9 in human synovial sarcoma cell growth and proliferation. Therefore, CDK9 may represent a promising target for the treatment of synovial sarcomas. © 2018 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 37:510–521, 2019.
Two compartment pharmacokinetic model describes the intra‐articular delivery and retention of rhprg4 following ACL transection in the Yucatan mini pig
Authors: Hurtig Mark , Zaghoul Iman , Sheardown Heather , Schmidt Tannin A. , Liu Lina , Zhang Ling , Elsaid Khaled A. , Jay Gregory D. 
Published: November 2018

ABSTRACTTreatment of the injured joint with rhPRG4 is based on recent observations that inflammation diminishes expression of native PRG4. Re‐establishing lubrication between pressurized and sliding cartilage surfaces during locomotion promotes the nascent expression of PRG4 and thus intra‐articular (IA) treatment strategies should be supported by pharmacokinetic evidence establishing the residence time of rhPRG4. A total of 21 Yucatan minipigs weighing ∼55 kg each received 4 mg of 131I‐rhPRG4 delivered by IA injection 5 days following surgical ACL transection. Animals were sequentially euthanized following IA rhPRG4 at 10 min (time zero), 24, 72 h, 6, 13 and 20 days later. The decay of the 131I‐rhPRG4 was measured relative to a non‐injected aliquot and normalized to the weight of cartilage samples, menisci and synovium, and known cartilage volumes from each compartment surface obtained from representative Yucatan minipig knees. Decay of 131I‐rhPRG4 from joint tissues best fit a two‐compartment model with an α half‐life (t1/2α) of 11.28 h and β half‐life (t1/2β) of 4.81 days. The tibial and femoral cartilage, meniscii, and synovium retained 7.7% of dose at 24 h. High concentrations of rhPRG4 were found in synovial fluid (SF) that was non‐aspiratable and resided on the articular surfaces, removable by irrigation, at 10 min following 131I‐rhPRG4 injection. Synovial fluid K21 exceeded K12 and SF t1/2β was 28 days indicating SF is the reservoir for rhPRG4 following IA injection. Clinical Significance: rhPRG4 following IA delivery in a traumatized joint populates articular surfaces for a considerable period and may promote the native expression of PRG4. © 2018 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 37:386–396, 2019.
Pseudospin‐Mediated Optical Spin–Spin Interaction in Nonlinear Photonic Graphene
Authors: Guan Chunying , Shi Jinhui , Liu Jianlong , Liu Hongchao , Li Ping , Ye Weimin , Zhang Shuang 
Published: November 2018

AbstractDynamic manipulation of the spin of photons is important for many applications ranging from optical sensing to optical information processing. In the past, the study on controlling the spin of light has focused on chiral materials, three‐dimensional structures lacking any mirror symmetries. However, the complexity of fabrication of such structures has hindered their practical applications. In this work, the dynamic switching of optical chirality in two‐dimensional honeycomb photonic crystal—the so‐called photonic graphene is explored. In particular, optical spin–spin interaction mediated by the pseudospin states of the photonic graphene is proposed. A circularly polarized pumping beam can lift the degeneracy at the Dirac cones, leading to chiral responses for a probe beam incident along the direction of the Dirac points. Interestingly, the chirality is determined by the both the valley index and the spin of the pumping beam. The proposed nonlinear photonic graphene offers a new route to manipulate valley‐ and spin‐dependent phenomena in 2D photonic systems.
Homogeneous B1+ for bilateral breast imaging at 7 T using a five dipole transmit array merged with a high density receive loop array
Authors: Krikken Erwin , Steensma Bart R. , Voogt Ingmar J. , Luijten Peter R. , Klomp Dennis W.J. , Raaijmakers Alexander J.E. , Wijnen Jannie P. 
Published: November 2018

To explore the use of five meandering dipole antennas in a multi‐transmit setup, combined with a high density receive array for breast imaging at 7 T for improved penetration depth and more homogeneous B1 field. Five meandering dipole antennas and 30 receiver loops were positioned on two cups around the breasts. Finite difference time domain simulations were performed to evaluate RF safety limits of the transmit setup. Scattering parameters of the transmit setup and coupling between the antennas and the detuned loops were measured. In vivo parallel imaging performance was investigated for various acceleration factors. After RF shimming, a B1 map, a T1‐weighted image, and a T2‐weighted image were acquired to assess B1 efficiency, uniformity in contrast weighting, and imaging performance in clinical applications. The maximum achievable local SAR10g value was 7.0 W/kg for 5 × 1 W accepted power. The dipoles were tuned and matched to a maximum reflection of −11.8 dB, and a maximum inter‐element coupling of −14.2 dB. The maximum coupling between the antennas and the receive loops was −18.2 dB and the mean noise correlation for the 30 receive loops 7.83 ± 8.69%. In vivo measurements showed an increased field of view, which reached to the axilla, and a high transmit efficiency. This coil enabled the acquisition of T1‐weighted images with a high spatial resolution of 0.7 mm3 isotropic and T2‐weighted spin echo images with uniformly weighted contrast.
A new biometric: In utero growth curves for metacarpal and phalangeal lengths reveal an embryonic patterning ratio
Authors: Rao Rashmi , Gornbein Jeffrey , Afshar Yalda , Platt Lawrence D. , DeVore Greggory R. , Krakow Deborah 
Published: November 2018

AbstractObjectivesThe objectives of this study are to develop gestational age‐specific growth curves for fetal third metacarpal and phalangeal lengths and to determine if fetal hand proportion is established in utero.MethodsThis prospective cross‐sectional study used 2D ultrasound across gestational ages 12 to 39 weeks to evaluate the third fetal metacarpal and phalangeal measurements. Gestational age‐specific reference growth curves were developed. Associations between continuous variables were assessed using Spearman correlations (rs) and restricted cubic splines. A nonlinear biologic regression model was used to predict metacarpal and phalangeal lengths as a function of gestational age. Measurements derived from five cases of thanatophoric dysplasia were used to determine if brachydactyly could be objectified.ResultsFetal metacarpal and phalangeal lengths are highly correlated across gestational age (rs = 0.96, P < 0.001). The mean fetal metacarpal to phalangeal ratio is constant from gestational age 15 to 39 weeks (rs = −0.07, P = 0.49). Third‐digit metacarpal and phalangeal lengths in thanatophoric dysplasia showed brachydactyly in all cases (5/5), and none of the cases (0/5) demonstrated a normal metacarpal to phalangeal ratio of 0.49.ConclusionWe present gestational age‐specific reference growth curves for fetal third metacarpal and phalangeal lengths, which may be used to detect brachydactyly. We demonstrate a prenatal metacarpal to phalangeal ratio of 1:2.
Risdiplam distributes and increases SMN protein in both the central nervous system and peripheral organs
Authors: Poirier Agnès , Weetall Marla , Heinig Katja , Bucheli Franz , Schoenlein Kerstin , Alsenz Jochem , Bassett Simon , Ullah Mohammed , Senn Claudia , Ratni Hasane , Naryshkin Nikolai , Paushkin Sergey , Mueller Lutz 
Published: November 2018

AbstractSpinal muscular atrophy (SMA) is a rare, inherited neuromuscular disease caused by deletion and/or mutation of the Survival of Motor Neuron 1 (SMN1) gene. A second gene, SMN2, produces low levels of functional SMN protein that are insufficient to fully compensate for the lack of SMN1. Risdiplam (RG7916; RO7034067) is an orally administered, small‐molecule SMN2 pre‐mRNA splicing modifier that distributes into the central nervous system (CNS) and peripheral tissues. To further explore risdiplam distribution, we assessed in vitro characteristics and in vivo drug levels and effect of risdiplam on SMN protein expression in different tissues in animal models. Total drug levels were similar in plasma, muscle, and brain of mice (n = 90), rats (n = 148), and monkeys (n = 24). As expected mechanistically based on its high passive permeability and not being a human multidrug resistance protein 1 substrate, risdiplam CSF levels reflected free compound concentration in plasma in monkeys. Tissue distribution remained unchanged when monkeys received risdiplam once daily for 39 weeks. A parallel dose‐dependent increase in SMN protein levels was seen in CNS and peripheral tissues in two SMA mouse models dosed with risdiplam. These in vitro and in vivo preclinical data strongly suggest that functional SMN protein increases seen in patients’ blood following risdiplam treatment should reflect similar increases in functional SMN protein in the CNS, muscle, and other peripheral tissues.
Mixed effects of landscape complexity and insecticide use on ladybeetle abundance in wheat fields
Authors: Yang Long , Zhang Qian , Liu Bing , Zeng Yingda , Pan Yunfei , Li Minlong , Lu Yanhui 
Published: November 2018

AbstractBACKGROUNDAlthough the abundance of insect natural enemies in crop fields may be influenced by the surrounding landscape and local field management, particularly insecticide use at the local scale, few studies have examined these factors simultaneously. In this study, we investigated the effects of landscape context and insecticide use in local fields on ladybeetle abundance in wheat fields in northern China.RESULTSWoodlots and fallow land were the most important landscape variables enhancing ladybeetle abundance. We used the cumulative percentage of these land types to characterize landscape complexity. Comparing the change in ladybeetle abundance in wheat fields within different landscapes and with different in‐field insecticide regimes, we found that although more complex landscapes enhanced ladybeetle abundance, the negative effects of insecticide use on ladybeetle populations were not offset by landscape complexity. Additionally, the positive effects of more complex landscapes on ladybeetle abundance were not significant in wheat fields subjected to high insecticide use.CONCLUSIONLadybeetle abundance is enhanced by landscape complexity, but this is modified by insecticide use in local fields. Within‐field efforts to maximize the conservation biological control of pests to improve crop yield should take into account the influence of the surrounding landscape. © 2018 Society of Chemical Industry