bluuebunny/crossref_metadata_2025_split huggingface dataset:
Participation Disenchants: How Online Political Participation Decreases Online Political Efficacy in China
Authors: Bogs Anton 
Published: December 2024

ABSTRACTExisting literature largely agrees that authoritarian regimes establish channels for political participation to gather valuable information on citizens' anti‐regime sentiments and policy preferences and to supervise lower‐level bureaucrats and firms. However, we lack knowledge of how citizens—key actors behind this informational function—actually experience these channels. I investigate citizens' experiences in the context of online political participation in China, drawing on survey data and online fieldwork. I find evidence suggesting that initial online political participation significantly decreases feelings of online political efficacy through a “disenchantment” process in which participating citizens gather sobering first‐hand experience and subsequently lower their assessment of the regime's responsiveness. On this basis, I develop a theory of an “information‐propaganda trade‐off” that authoritarian regimes face: to obtain more information, authoritarian regimes can encourage more citizens to participate. Once citizens participate, however, they grow disillusioned, and the regime's propaganda becomes less convincing.
Exhaustion Disorder in Primary Care: A Comparison With Major Depressive Disorder and Adjustment Disorder
Authors: Sennerstam Victoria , Hedman‐Lagerlöf Erik , Nilsonne Gustav , Lekander Mats , Rück Christian , Wallert John , Axelsson Erland , Lindsäter Elin 
Published: December 2024

ABSTRACTExhaustion disorder (ED) was introduced to the Swedish version of the International Classification of Diseases, 10th edition (ICD‐10) 2005. Primarily characterized by general fatigue and cognitive deficits, ED has become one of the most common mental health diagnoses in Sweden. Little is still known regarding the discriminative validity of the ED diagnosis and how it relates to other diagnostic constructs. The study aimed to investigate the discriminative validity of ED compared with two similar diagnoses, major depressive disorder (MDD) and adjustment disorder (AD). Using data from a sample of patients with a principal diagnosis of either ED (n = 352), MDD (n = 99), or AD (n = 302), we compared demographic and clinical variables and scores on self‐report symptom scales. Results showed that ED patients were of a higher age and had a higher frequency of sickness absence than MDD and AD patients. There was a substantial overlap of symptoms between ED and MDD, only differing on two of nine self‐report symptom scales, with ED patients rating lower work ability d = −0.37 and alcohol consumption d = −0.57. Compared with AD patients, ED patients reported more severe symptoms in every symptom domain. Given the prevalent use of ED diagnosis, its diagnostic validity and clinical usefulness merit further attention.
A bioassay of crop response to fertilizer nutrients in soils from a chronosequence of reclaimed natural gas pipeline rights‐of‐way
Authors: Muitire Clemence , Zvomuya Francis , Amarakoon Inoka , Adesanya Theresa , Mante Afua 
Published: December 2024

AbstractConstruction of underground pipelines on cropland impacts the soil ecosystem, resulting in crop yield losses persisting for several years after right‐of‐way (ROW) reclamation. Information on whether higher than recommended fertilizer application rates could improve productivity of reclaimed ROWs is scarce. The objective of this growth room bioassay was to determine the productivity response of a chronosequence of reclaimed ROW soils to differential fertilizer rates. Bulk soil samples were collected from the 0 to 20 cm soil layer on two ROWs of different ages (i.e., time since reclamation, TSR). The experiment was laid out in a completely randomized design with a 3 × 3 factorial treatment structure with three replications per treatment. The factors were TSR (4 and 10 year plus undisturbed (off‐ROW) sites) and fertilizer application rates (no fertilizer (Check); recommended rate (100%) of nitrogen (N), phosphorus (P), potassium (K), and sulphur (S); and 150% of the recommended N, P, K, and S rates). The recommended nutrient rates produced 66% lower canola dry matter yield (DMY) and 45% lower wheat DMY in the 4‐year ROW soil relative to the off‐ROW soil. Increasing the rate to 150% of the recommended rate significantly increased canola and wheat DMY in the 4‐year ROW soil to levels similar to those in the off‐ROW soil receiving the recommended rate. Nitrogen uptake by canola and wheat was 30%–45% lower, while P uptake was 40%–55% lower in the ROW soils than in the off‐ROW soil. These results indicate incomplete recovery of the ROW soils within at least the first 4 year following completion of reclamation. However, crop yields were not significantly different between the 10 year ROW and the off‐ROW at 100% fertilizer rate suggesting that productivity had been restored to off‐ROW levels by year 10 following reclamation. Findings from this study will contribute towards the formulation of strategies for improving the productivity of reclaimed ROWs on cropland.
Advancing nature‐based solutions through enhanced soil health monitoring in the United Kingdom
Authors: Giuliani Licida M. , Warner Emily , Campbell Grant A. , Lynch John , Smith Alison C. , Smith Pete 
Published: December 2024

AbstractSoil health is a critical component of nature‐based solutions (NbS), underpinning ecosystem multifunctionality and resilience by supporting biodiversity, improving carbon sequestration and storage, regulating water flow and enhancing plant productivity. For this reason, NbS often aim to protect soil health and restore degraded soil. Robust monitoring of soil health is needed to adaptively manage NbS projects, identify best practices and minimize trade‐offs between goals, but soil assessment is often underrepresented in NbS monitoring programmes. This paper examines challenges and opportunities in selecting suitable soil health metrics. We find that standardization can facilitate widespread monitoring of soil health, with benefits for stakeholders and user groups. However, standardization brings key challenges, including the complexity and local variability of soil systems and the diverse priorities, skills and resources of stakeholders. To address this, we propose a flexible, interdisciplinary approach combining soil science, ecology and socio‐economic insights. We introduce an interactive tool to help users select suitable soil and biodiversity metrics, which are context and scale‐specific, and suggest avenues for future research. We conclude that integrating soil health into NbS through new and improved monitoring approaches, newly available datasets, supportive policies and stakeholder collaboration can enhance the resilience and effectiveness of NbS, contributing significantly to global sustainability goals.
“Are my blood products coming?”: Implementation of a novel blood product tracker in the electronic health record system
Authors: Chai Tina , Hartzell Connor , Winstead Randy , Krokosky Kirk , Atchison Kaycie , Mueller Angela , Hall Erika , Wanderer Jonathan P. , Andrews Jennifer 
Published: December 2024

AbstractBackgroundBlood transfusions are the most common procedure performed in American hospitals. The steps required for blood product delivery are often misunderstood by providers, leading to numerous phone calls to the blood bank requesting order status. Distracting calls can lengthen turnaround time, especially during blood product or staff shortages. We sought a tool to address these questions and reduce distraction. This study highlights a novel blood tracker tool implemented in the electronic health record (EHR) that allows providers to see their blood order's status.Study Design and MethodsWith a multidisciplinary team of healthcare professionals, we constructed a user‐friendly blood tracker highly visible in our EHR. It shows the status of a blood product in real time from “order printed” to “preparing” to “on its way.” We surveyed blood bank technologists to determine if call volume and distraction changed.ResultsWe counted the number of views per month as a surrogate of usage. The blood tracker was viewed 109,626 times per month on average from January through December 2023. The fraction of technologists who received 21 or more calls per shift decreased by 47%.DiscussionWe successfully constructed and implemented a novel blood tracker into our EHR that relays the status of a blood product. It is a highly viewed piece of information in our EHR and decreases blood bank call volume as reported by blood bank technologists. Its success demonstrates that closed‐loop communication between the lab and providers regarding blood products is beneficial within our organization and potentially others.
Localised apolipoprotein A‐I amyloidosis arising in a fibroadnexal hamartoma in a dog
Authors: Murakami Tomoaki , Owaku Kenta , Kobayashi Natsumi , Itoh Yoshiyuki , Hisada Miki , Craig Linden E. 
Published: December 2024

AbstractCanine apolipoprotein A‐I (ApoA‐I) amyloidosis has only been reported as an age‐related pulmonary vascular condition. In this report, the authors identified cutaneous ApoA‐I amyloidosis within a fibroadnexal hamartoma in a dog. Based on proteomic analysis using mass spectrometry, the mechanism of ApoA‐I amyloidogenesis is discussed.
Numerical Assessment of an Aerodynamic Probe to Enable Short Focal Length Laser Diagnostics in High Temperature Supersonic Flows Based on Flow Disturbance
Authors: Lasala Ignacio , McKelvy Aubrey , Braun James , Paniagua Guillermo , Choquet Etienne , Andre Thierry , Falempin Francois 
Published: December 2024

Abstract
This article evaluates the use of an actively cooled aerodynamic probe body with integrated optics to perform short focal length laser diagnostics within high-temperature, high-supersonic flows. A novel probe with a “ship's bow” shape and an open cycle cooling scheme ending in a matrix of effusion holes is presented. The flow around the probe is studied numerically using 3D steady Reynolds-averaged Navier–Stokes (RANS) simulations at Mach 6, with freestream total conditions of 1700 K and 44.2 bar. The laser trajectory is calculated using the ray propagation equation to ensure that it deviates minimally while going through regions of gradients in refractive index. The location and shape of the detached shock formed ahead of the probe is extracted, and the minimum focal length achievable for measurement of the undisturbed flow field is determined. The sensitivity of the bow shock shape to changes in cooling pressure between 1.33 and 1.835 bar and to blocked holes has been computed. Finally, the flow through the effusion system of the probe is tested experimentally, ensuring its proper operation, and checking the consistency of the effusion boundary conditions used in the numerical study.
The gE/gI complex is necessary for kinesin-1 recruitment during alphaherpesvirus egress from neurons
Authors: Diwaker Drishya , Kim DongHo , Cordova-Martinez Dylann , Pujari Nivedita , Jordan Bryen A. , Smith Gregory A. , Wilson Duncan W. 
Published: December 2024

ABSTRACT

Following reactivation of a latent alphaherpesvirus infection, viral particles are assembled in neuronal cell bodies, trafficked anterogradely within axons to nerve termini, and spread to adjacent epithelial cells. The virally encoded membrane proteins US9p and the glycoprotein heterodimer gE/gI of pseudorabies virus (PRV) and herpes simplex virus type 1 (HSV-1) play critical roles in anterograde spread, likely as a tripartite gE/gI-US9p complex. Two kinesin motors, kinesin-1 and kinesin-3, are implicated in the egress of these viruses, but how gE/gI-US9p coordinates their activities is poorly understood. Here, we report that PRV, in addition to associating with the kinesin-3 motor KIF1A, recruits the neuronal kinesin-1 isoforms KIF5A and KIF5C, but not the broadly expressed isoform KIF5B, during egress from differentiated CAD neurons. Similarly, in the axons of dorsal root ganglia (DRG)-derived sensory neurons, PRV colocalized with KIF5C but not KIF5B. In differentiated CAD cells, the association of KIF1A with egressing PRV was dependent upon US9p, whereas the recruitment of KIF5 isoforms required gE/gI. Consistent with these findings, the number of PRV particles trafficking within CAD neurites and the axons of DRG neurons increased when kinesin-1 motor activity was upregulated by hyperacetylating microtubules using trichostatin A (TSA) or tubacin, and this enhanced trafficking depended upon the presence of gE/gI. We propose that, following its recruitment by US9p, KIF1A delivers PRV particles to a location where KIF5 motors are subsequently added by a gE/gI-dependent mechanism. KIF5A/C isoforms then serve to traffic viral particles along axons, resulting in characteristic recrudescent infection.

IMPORTANCE
Alphaherpesviruses include important human and veterinary pathogens that share a unique propensity to establish life-long latent infections in the peripheral nervous system. Upon reactivation, these viruses navigate back to body surfaces and transmit to new hosts. In this study, we demonstrate that the virus gE/gI-US9p membrane complex routes virus particles down this complex neuronal egress pathway by coordinating their association with multiple kinesin microtubule motors.
Genome sequences of four novel
Endozoicomonas
strains associated with a tropical octocoral in a long-term aquarium facility
Authors: Marques Matilde , da Silva Daniela M.G. , Santos Elsa , Baylina Núria , Peixoto Raquel , Kyrpides Nikos C. , Woyke Tanja , Whitman William B. , Keller-Costa Tina , Costa Rodrigo 
Published: December 2024

ABSTRACT

We report the genome sequences of four
Endozoicomonas
sp. strains isolated from the octocoral
Litophyton
maintained long term at an aquarium facility. Our analysis reveals the coding potential for versatile polysaccharide metabolism; Type II, III, IV, and VI secretion systems; and the biosynthesis of novel ribosomally synthesized and post-translationally modified peptides.
Transition from neonatal to paediatric intensive care of very preterm-born children: a cohort study of children born between 2013 and 2018 in England and Wales
Authors: van Hasselt Tim J , Newman Suzy , Kanthimathinathan Hari Krishnan , Davis Peter J , Draper Elizabeth S , Gale Chris , Battersby Cheryl , Seaton Sarah E 
Published: December 2024

ObjectiveFollowing very preterm birth, some children require ongoing intensive care after the neonatal period and transition directly from neonatal units (NNUs) to paediatric intensive care units (PICUs) around term-corrected age.We aimed to understand, at a national level, characteristics and outcomes of children born very preterm who transitioned directly from NNUs to PICUs.DesignRetrospective cohort study, using data linkage of National Neonatal Research Database, Paediatric Intensive Care Audit Network and Office for National Statistics datasets.SettingAll NNUs and PICUs in England and Wales.PatientsChildren born <32 gestational weeks between 1 January 2013 and 31 December 2018, admitted to NNUs, and who transitioned directly to PICU without return to NNU at ≥36 weeks corrected gestation age were included.Main outcome measuresMortality, length of PICU stay, invasive ventilation in PICU (including via tracheostomy), PICU readmission until 2 years of age.ResultsDirect NNU-to-PICU transitions occurred in 276 babies during the study period. An increasing yearly trend was observed: 36 transitions of babies born in 2013, 65 in 2018.Of this cohort, 22% of children died before their second birthday, 59% of survivors had ≥1 PICU readmission, 33% of children had long stays in PICU (≥28 days) and 25% received tracheostomy ventilation.ConclusionsAn increasing number of very preterm children require ongoing intensive care at the end of their neonatal stay, with high rates of mortality and morbidity. Multidisciplinary involvement and planning around the time of transition from NNU to PICU, informed by national guidance, may be beneficial.
Glucosinolate profiling in Cleome gynandra L. aerial parts based on two extraction methods
Authors: Mano Jonas , Dicko Cedric , Ouédraogo Jean Claude W. , Bonzi-Coulibaly Yvonne L. 
Published: December 2024

Glucosinolates and their degradation products from Cleome gynandra L. are known for their beneficial effects in traditional medical use. As part of daily nutrient intake, the areal parts of this herb are cooked and consumed, whereas the residual water from boiling is discarded. However, it may contain valuable bioactive metabolites. Therefore, we focus our investigations on Cleome gynandra L. for the presence of glucosinolates using two extraction methods (conventional and unconventional) and according to the physiological stage of growth of the plant. The results showed that glucosinolate contents expressed in mg of glucocapparin/g dry matter (mg/g) differed quantitatively according to the extraction method and physiological development stage. Glucocapparin content was 8.24 mg/g dry matter for the methanolic extract (conventional method) compared to 5.01 mg/g dry matter for the aqueous extract at the fruiting stage of the plants. LC-MS and 1H NMR analysis confirmed the identity of the major glucosinolate as glucocapparin. Quantification revealed the same variation trend in glucosinolate content according to the physiological stage of plant growth with the two extraction methods, i.e., 2.58, 4.74, and 5.01 mg glucocapparin/g dry matter for aqueous extracts (unconventional method) and according to the vegetative, flowering, and fruiting stages, respectively. However, it appears that aqueous extracts (cooking wastewater) obtained from areal parts of Cleome gynandra L. could constitute enriched extracts in glucosinolates from Cleome gynandra L. for phytoprotective applications from the fruiting stage.
Simple approximate model for pion masses
Authors: Lindqwister Ulf J. 
Published: December 2024

Abstract
Closed expressions for the masses of the charged and neutral pions are derived based on a simple approximate model for electrostatic screening when a proton is located adjacent to a neutron. The estimated mass values agree to a few percent of experimentally measured values. The electric dipole moment of the deuteron is also estimated based on the phenomenological toy model used here.
Diagnostic Efficacy of Vibration‐Controlled Transient Elastography in Patients With Metabolic Dysfunction–Associated Liver Disease and Chronic Hepatitis B
Authors: Liu Yaoyu , Huang Zhizhen , Lan Xinya , Jia Min , Zheng Xiaoting , Hu Min , Luo Huiying , Zhang Luyun , Li Xuejing , Chen Shaodong , Li Yunru , Liang Huiqing 
Published: December 2024

Aim of the Study: HBV‐infected individuals are also presenting with MASLD. However, the value of VCTE for detecting hepatic fibrosis and steatosis in CHB patients concurrent with MASLD is unclear. In patients with combined CHB and MASLD, we intend to assess the diagnostic efficacy of VCTE in determining the extent of fibrosis and steatosis.Methods: This retrospective study involved 368 patients diagnosed with chronic HBV infection combined with MASLD who received liver biopsy and VCTE at Xiamen City Traditional Chinese Medicine Hospital from June 2018 to June 2023. The cutoff values for liver stiffness measurement (LSM) and controlled attenuation parameter (CAP) were determined via the use of the cross‐validated area under the receiver operating characteristic (AUROC) curve analyses to identify pairwise fibrosis stage and grade, respectively. The diagnostic statistics were calculated with a 90% fixed sensitivity and 90% specificity.Results: An AUROC of 0.86 (95% CI: 0.76–0.95) was determined by a LSM cutoff value of 11.25 to identify patients with cirrhosis. Patients have the following values: sensitivity, 0.79; specificity, 0.90; PPV, 0.89; and NPV, 0.81. An AUROC of 0.84 (95% CI: 0.76–0.95) was determined by a CAP cutoff value of 313 to identify patients with severe steatotic liver. Patients have the following values: sensitivity, 0.86; specificity, 0.82; PPV, 0.82; and NPV, 0.85.Conclusion:In this investigation of adult patients diagnosed with CHB with MASLD, VCTE demonstrated a robust capability to differentiate cirrhosis and severe steatotic liver.
Abstract A003: In vitro anticancer activities of some organoplatinum (IV) derivatives
Authors: Howard William A. 
Published: December 2024

Abstract
Recent investigations into organoplatinum (IV) complexes as potential anticancer agents have shown considerable promise. Unlike cisplatin, these compounds are more stable in physiological environments and generally exhibit fewer side effects. Additionally, chelating aromatic ancillary ligands have been found to enhance the intercalation of metal-based agents into tumor DNA. This study aimed to synthesize novel organoplatinum (IV) complexes with chelating aromatic ligands and evaluate their anticancer efficacy through in vitro assays. Five complexes were synthesized: [Pt(CH3)2X2{2,2’-bipyridine-4,4’-R2}] (X = Br, I; R = H, CO2H) and [{Pt(CH3)3}2(μ-I)2(μ-adenine)]. These were characterized by single crystal X-ray diffraction and assessed for anticancer activity. The MTT assays indicated that the [Pt(CH3)2X2{2,2’-bipyridine}] complexes were more cytotoxic to the ZR-75-1 human breast cancer cell line than cisplatin, with LC50 values of 6.1 µM for X = I, 11.5 µM for X = Br, compared to 16.4 µM for cisplatin. Furthermore, the sulforhodamine B assays conducted by the National Cancer Institute's Developmental Therapeutics Program revealed that [Pt(CH3)3}2(μ-I)2(μ-adenine)] was highly effective against various cancer cell lines. Notably, it showed an LC50 value of 5.20 µM against the glioblastoma multiforme SF-539 cell line, whereas cisplatin and temozolomide had LC50 values exceeding 100 µM. Similarly, [Pt(CH3)3}2(μ-I)2(μ-adenine)] had an LC50 value of 5.99 µM against the renal carcinoma RXF-393 cell line, with cisplatin and cabozantinib showing LC50 values above 100 µM. While these results highlight the superior cytotoxicity of the tested organoplatinum (IV) complexes, further research and development are required before these compounds can be considered for commercial use as chemotherapy drugs.
Citation Format: William A. Howard. In vitro anticancer activities of some organoplatinum (IV) derivatives [abstract]. In: Proceedings of the AACR Special Conference in Cancer Research: Optimizing Therapeutic Efficacy and Tolerability through Cancer Chemistry; 2024 Dec 9-11; Toronto, Ontario, Canada. Philadelphia (PA): AACR; Mol Cancer Ther 2024;23(12_Suppl):Abstract nr A003
Abstract IA018: Pan-RAF-MEK molecular glue NST-628 is a potent and brain-penetrant inhibitor of the RAS-MAPK pathway
Authors: Hoeflich Klaus P. 
Published: December 2024

Abstract
Alterations in the RAS-MAPK signaling cascade are common across multiple solid tumor types and is a driver for many cancers. NST-628 is a potent pan-RAF-MEK molecular glue that prevents phosphorylation and activation of MEK by RAF, overcoming the limitations of traditional RAS-MAPK inhibitors and leading to deep durable inhibition of the pathway. Cellular, biochemical, and structural analysis of RAF-MEK complexes show that NST-628 engages all isoforms of RAF, including ARAF, and prevents the formation of BRAF-CRAF heterodimers, a differentiated mechanism from all current RAF inhibitors. With a potent and durable inhibition of the RAF-MEK signaling complex as well as high intrinsic permeability into the brain, NST-628 demonstrates broad efficacy in cellular and patient-derived tumor models harboring diverse MAPK pathway alterations, including orthotopic intracranial models. Given a mechanism differentiated from previous therapies targeting RAF or MEK catalytic activity, NST-628 is positioned to make an impact clinically in an areas of unmet patient need.
Citation Format: Klaus P. Hoeflich. Pan-RAF-MEK molecular glue NST-628 is a potent and brain-penetrant inhibitor of the RAS-MAPK pathway [abstract]. In: Proceedings of the AACR Special Conference in Cancer Research: Optimizing Therapeutic Efficacy and Tolerability through Cancer Chemistry; 2024 Dec 9-11; Toronto, Ontario, Canada. Philadelphia (PA): AACR; Mol Cancer Ther 2024;23(12_Suppl):Abstract nr IA018.