bluuebunny/crossref_metadata_2025_split huggingface dataset:
Characteristics and clinical significance of magnetic resonance imaging manifestations of cerebral small vessel disease in acute period of ischemic stroke
Authors: Kayleva N A , Kulesh A A , Gorst N Kh , Bykova A Yu , Drobakha V E , Shestakov V V 
Published: August 2018

Aim. To characterize magnetic-resonance imaging manifestations of cerebral small vessel disease in patients in acute period of ischemic stroke and to study their clinical significance.
Methods. 56 patients in acute period of ischemic stroke and 10 subjects without stroke and cognitive impairment were examined. Magnetic-resonance tomography of the brain was performed to all patients and healthy subjects to assess the quantity of lacunes, perivascular spaces, leukoaraiosis and cerebral microbleeds. Based on analysis of 4 neurovisual markers of cerebral small vessel disease, an integral scale was developed. The obtained results were evaluated in association with a wide spectrum of clinical data.
Results. Patients in acute period of ischemic stroke are characterized by higher quantitative expression of certain markers of cerebral small vessel disease in comparison with healthy age-matched subjects. A correlation between neuroimaging markers of cerebral small vessel disease and patients` age, severity and etiology of the stroke was observed. Total expression of cerebral small vessel disease, assessed using the integral score turned out to be higher in the group of stroke than in healthy elderly persons. High rates of certain markers of cerebral small vessel disease and integral scale score are associated with low mobility of patients, neurological deficiency and dependence in daily activities on discharge.
Conclusion. In patients in acute period of ischemic stroke, higher expression of certain markers of cerebral small vessel disease and their total evidence were revealed in comparison with healthy people; total indicator of cerebral small vessel disease expression is associated with neurological and functional outcome of acute period of stroke.
Influence of various treatment methods on the content of cytokines in saliva of patients with chronic sialadenitis
Authors: Aliev S Z 
Published: August 2018

Aim. Study of the main cytokines (interleukin-1β and -2, interferon γ) in the mixed saliva from patients with chronic sialadenitis on the basic and comprehensive treatment dynamically.
Methods. During the period of 2014 to 2017 we performed examination and treatment of patients with salivary gland diseases. Out of them we defined a group with chronic non-specific sialadenitis including 45 patients seen in the clinic in exacerbation. Patients in the comparison group received basic treatment. Patients in the study group additionally to conventional treatment were administered local immunotherapy. Measurement of cytokine levels in the oral fluid was performed in 45 patients with chronic sialadenitis in exacerbation and in 10 practically healthy subjects.
Results. The level of interleukin-1β in saliva was found to be significantly increased before treatment (p <0.05). After the treatment interleukin-1β level in saliva decreased in both groups but most significantly this parameter decreased in the study group. After including local immunocorrection into the treatment complex dynamic decrease of interleukin-2 to 14.7±0.4 pg/ml was registered, which apparently is associated with stabilization of immune processes in the oral cavity. After the treatment conducted according to traditional scheme in the comparison group the level of interferon γ in saliva increased to 7.2±0.2 pg/ml which is 1.1 times higher than before treatment.
Conclusion. In patients with chronic sialadenitis in exacerbation the level of interleukin-1β statistically significantly increases by 1. times (p <0.05), interleukin 2 - by 2.1 times (p <0.05) and the level of interferon γ decreases by 1.4 times (p <0.05) which is indicative of immunological signs of inflammatory reaction; use of local immunocorrection leads to more prominent decrease of interleukin-1β (by 20.3 vs 16.2% in comparison group; p <0.05), interleukin-2 (by 38.8 vs 26.6%; p <0.05) and increase of interferon γ (by 21.2 vs 12.5% in comparison group; p <0.05).
Anemia of chronic diseases in patients with dilated and ischemic cardiomyopathy
Authors: Chepurnaya A N , Nikulicheva V I , Zagidullin I M , Lekhmus T Yu , Rakhmatullina A R , Demkina L S 
Published: August 2018

Aim. To estimate the effect of anemia of chronic diseases on the processes of cardiovascular system remodeling in patients with dilated cardiomyopathy and ischemic cardiomyopathy.
Methods. The study included 27 patients with dilated cardiomyopathy with anemia, 19 with dilated cardiomyopathy without anemia, 11 with ischemic cardiomyopathy with anemia, 34 with ischemic cardiomyopathy without anemia, and 30 healthy individuals. In these comparison groups, peripheral blood, mean corpuscular hemoglobin and mean cell hemoglobin concentration, reticulocytes, serum iron and ferritin were examined. Electrocardiography, echocardiography, scintigraphy and coronary angiography were performed.
Results. In all groups identical signs of chronic heart failure class 3 and 4 were found to be predominant, which was confirmed by a significant decrease of blood pressure, stroke volume, ejection fraction, increase of end systolic and diastolic volumes and sizes, as well as left and right atrial size. Patients with dilated and ischemic cardiomyopathy with anemia had decreased hemoglobin, number of erythrocytes and platelets, positive correlation between hemoglobin and serum iron (r=0.49, p=0.000), red blood cells and ferritin (r=0.61, p=0.000), negative correlation between hemoglobin and ferritin (r=-0.51, p=0.02). In ischemic cardiomyopathy with anemia positive correlation was found between hemoglobin and serum iron (r=0.54, p=0.000), erythrocytes and ferritin (r=0.49, p=0.03), negative correlation - between hemoglobin and ferritin (r=0.54, p=0.03).
Conclusion. In patients with dilated and ischemic cardiomyopathy no significant effect of anemia of chronic diseases on heart remodeling processes was revealed.
Comparative measurement of concentration of lithium, circulating immune complexes and complement activity in blood and lymph in experimental anaphylactic shock and Arthus phenomenon
Authors: Alieva T R 
Published: August 2018

Aim. Comparative measurement of concentration of lithium, circulating immune complexes and complement activity in animals’ blood and lymph in experimental anaphylactic shock and Arthus phenomenon.
Methods. Experiments were conducted on 27 chinchilla rabbits in double series. The studied values of lithium, concentration of circulating immune complexes and complement activity in intact animals were used as controls.
Results. On day 7 of sensibilisation before anaphylactic shock the titer of complement components in the blood decreased by 1.4 times (p <0.001) compared to parameters of intact animals, at the stage of anaphylactic shock sharp decrease of its concentration to undetermined values was observed (p <0.001). The blood concentration of circulating immune complexes increased by 4.4 times, and at the stage of anaphylactic shock (day 21) its increase by 7.1 times was observed (p <0.001). Lithium concentration decreased to 0.03 mmol/L at the stage of anaphylactic shock (p <0.001). In Arthus phenomenon at the stage of sensibilisation (day 5) the blood complement titer decreased by 1.1 times (p <0.001), during resolution period - by 10.1 times (p <0.001). The blood concentration of circulating immune complexes increased by 4.5 times (p <0.001) at the stage of sensibilisation (day 5), and at the stage of Arthus phenomenon - by 11.8 times compared to intact animals (p <0.001).
Conclusion. The concentration of circulating immune complexes increases in anaphylactic and immunocomplex reactions, besides, more significantly in Arthus phenomenon (23 r.u. in anaphylactic shock versus 38.1 r.u. in Arthus phenomenon); lithium concentration in anaphylactic shock decreases by 5.2 times which is indicative of inhibitory action of this microelement in allergic reactions.
Comparison of registration parameters of angiotensin converting enzyme inhibitors and angiotensin II receptor blockers in different countries
Authors: Garaeva A F , Ziganshin A U , Ziganshina L E 
Published: August 2018

Aim. Conduction of quantitative and qualitative analysis of registration parameters of medications of two groups - angiotensin converting enzyme inhibitors and angiotensin II receptor blockers in Russian Federation compared to those of leading drug regulators.
Methods. The whole list of currently existing angiotensin converting enzyme inhibitors and angiotensin II receptor blockers according to international Anatomical Therapeutic Chemical Classification of drugs was analyzed by quantitative and qualitative characteristics in four national drug regulators: State drug register of the Russian Federation, American drug regulator - Food and Drug Administration, European Medicines Agency, and Australian drug regulator - Therapeutic Goods Administration.
Results. It was found that by the number of registered international nonproprietary names and by the number of trade names in the group of angiotensin converting enzyme inhibitors the leading position is taken by State drug registry of the RF, and in the group of angiotensin II receptor blockers Therapeutic Goods Administration is leading. On the territory of Russian Federation among angiotensin converting enzyme inhibitors, lisinopril, captopril, perindopril and enalapril are registered in the highest numbers of trade names, and among angiotensin II receptor blockers - losartan and valsartan. The example of the best practice is presented by European Medicines Agency with the lowest number of registered international nonproprietary and trade names. The qualitative analysis of registration parameters of angiotensin converting enzyme inhibitors and angiotensin II receptor blockers (accepted indications) revealed that in RF the highest number of indications for both angiotensin converting enzyme inhibitors and angiotensin II receptor blockers is accepted compared to those of the leading drug regulators. The example of the best practice by this criterion is presented by the European regulator - European Medicines Agency. Based on the understanding that all international nonproprietary names in every analyzed pharmacological group are medications of the «me too» category, the decrease of the number of registration positions by national regulator and thorough analysis of evidence of effects are recommended when approving indications.
Conclusion. In the official state drug registry of RF compared to three foreign drug regulators, the highest number of international nonproprietary names and trade names of angiotensin converting enzyme inhibitors are presented as well as indications for both angiotensin converting enzyme inhibitors and angiotensin II receptor blockers.
Laparoscopic inguinal hernia repair without fixation
Authors: Tarasenko S V , Bogomolov A Yu , Natal'skiy A A , Zaytsev O V , Peskov O D , Kadykova O A , Mokrova A V 
Published: August 2018

Aim. Comparison of the immediate and long-term results of laparoscopic inguinal hernia repair with and without mesh implant fixation.
Methods. The study included 145 patients over 18 years of both genders with inguinal hernias, including those with relapse after auto-hernioplasty. Patients underwent transabdominal preperitoneal hernioplasty with the application of mesh implant. Patients were randomly divided into two groups matched by age, sex and the type of hernias. In group 1 (n=71) patients underwent laparoscopic hernia repair without fixation, which in case of a direct inguinal hernia was supplemented with transverse fascia endoloop plication; and in group 2 (n=74) - laparoscopic hernioplasty using hernia stapler and/or endocorporal suture.
Results. The duration of surgical intervention in compared groups did not differ significantly (p=0.92), there was no recurrence of hernia in either group. The patients of group 1 had less pain syndrome in the early postoperative period, which was expressed in a significantly lower need for narcotic analgesics in terms of the equivalent amount of morphine (p=0.03) and shorter duration of hospital stay (p=0.5). Advantages of laparoscopic hernioplasty without fixation are the following: (1) intensity of pain syndrome in patients operated by this method is less than in patients operated by the traditional method, during both the first 24 hours after the surgery (p=0.45) and on day 5 (p=0.69); (2) there is no need to purchase foreign-made devices (hernia staplers) and self-locking endoprostheses.
Conclusion. The long-term and immediate results of laparoscopic inguinal hernia repair without mesh implant fixation are not inferior to the traditional methods of implant application; besides, the studied method has a raw of advantages.
Anti‐Dam Protests in India: Examining the Profile of the Sardar Sarovar Dam
Authors: Ranjan Amit 
Published: August 2018

AbstractAlmost all protests against large dams in India have failed to stop the construction of the respective projects. The latest one is protest against the Sardar Sarovar Dam. Ignoring the demands of the protestors, the height of the Sardar Sarovar Dam has been increased, and in 2017, finally, the 138.68 m high dam was inaugurated by the Indian Prime Minister, Narendra Modi. The construction of the Sardar Sarovar Dam has caused submergence of a large area of land and has displaced many people in the Narmada basin. Due to the impact on local communities, the Narmada Bachao Andolan has been leading peaceful protest against the Sardar Sarovar Dam since the 1980s. In addition to the debates on construction of the Sardar Sarovar Dam is the issue of resettlement and rehabilitation of the people and families affected by it. Protestors and activists allege that the people and families affected have not been properly compensated, resettled, and rehabilitated by the government. This paper critically examines the evolution of the Sardar Sarovar Dam, the impact it has on the people and land in its command area, and the history of protest and activism relating to the dam.
Knowledge Management and Integrated Water Resource Management—Types of Knowledge and Key Considerations
Authors: Delfau Karen 
Published: August 2018

AbstractKnowledge sharing and transfer in the field of Integrated Water Resource Management, on a global scale, can be improved with an understanding of cultural considerations, technical opportunities, and constraints, and the theory underpinning knowledge management. This paper explores existing literature and applies a human centered design approach (customer journey mapping) to collect data. Fourteen semi‐structured interviews with practitioners across the Asia Pacific region provide a basis to understand knowledge management barriers, breakthroughs, and outcomes to support improved knowledge sharing and transfer among water management practitioners. Findings identify a set of areas of needed knowledge, demonstrate that virtual means of knowledge sharing and connection are best supplemented with face‐to‐face interaction, and argue for a facilitated approach to best achieve success. The research conducted in this study serves to support the development of a global community of practice for water management practitioners to better support integrated water management outcomes.
REMINERALIZING THERAPY WITH TOOTH MOUSSE AND PASTE PLUS
Authors: Леонтьева Е. , Leontieva E.Y. , Ткачук О. , Tkachuk O. , Нектаревская И. , Nektarevskaya I. 
Published: August 2018

<p>Dental caries is still one of the main diseases dealt with by dentistry, and its diagnosis, prophylaxis and treatment occupy the leading place in therapeutical dentistry. the range of products applied in remineralizing therapy is quite wide. the authors of this article study gc tooth mousse and gc mi paste plus as being the most effective for control over tooth hard tissue de- and remineralization process.</p><p> </p>
OCCUPATIONAL HAZARD OF WORK AS A DENTIST. PSYCHOPHYSIOLOGICAL FACTOR
Authors: Ожгихина Н. , Ozhgihina N. , Ожгихина Ж.Э. , Ozhgihina J. 
Published: August 2018

<p>Occupational hazard is labor factor with an adverse effect on the health of the doctor. psychophysiological factors include prolonged standing or sitting, static load on the hands and eyestrain. completed questionnaires 40 dentists. wrong position of the doctor at work leads to disorders of the musculoskeletal system. most doctors deteriorated vision while working as a dentist. this is due to the fact that almost none of them make eye exercises and does not comply with proper work and rest. some dentists have a change of fingers and hands, work-related dental instruments.</p><p> </p>
MODERN METHODS OF PREVENTION AND TREAT- MENT OF POSTOPERATIVE HYPERESTHESIA IN PROSTHODONTICS. REVIEW
Authors: Жолудев С. , Zholudev S. , Димитрова Ю. , Dimitrova U. 
Published: August 2018

<p>Based on the study of modern literature the methods of prevention and treatment of hyperesthesia after the abutment teeth preparation are presented.</p><p> </p>
PRECANCEROUS LESIONS IN STRUCTURE OF ORAL MUCOSA DISEASES (ACCORDING TO MEDICAL ADVISORY DATA)
Authors: Гилева О. , Gileva O. , Либик Т. , Libik T. , Позднякова А. , Pozdnyakova A. , Сатюкова Л. , Satyukova L. 
Published: August 2018

<p>The study presents the results of the research on the structure, local and systemic risk factors, peculiarities of the clinical manifestation, quality of primary diagnosis of precancerous oral mucosa lesions and red border of the lip. The high percentage of diagnostic errors and lack of oncological awareness of dentists, as well as the necessity of inclusion of precancer early detection techniques are noted. </p>
FORECASTING, FEATURES OF CLINIC AND TREATMENT OF A SYSTEM HYPOPLASIA OF THE SECOND TEETH COMPLICATED BY CARIOUS PROCESS
Authors: Луницына Ю. , Lunitsyna J. , Токмакова С. , Tokmakova S. , Плешакова Т. , Pleshakova T. , Косилова А. , Kosilova A. , Осколкова Д. , Oskolkova D. 
Published: August 2018

<p>In article the characteristic of various clinical forms of a hypoplasia of enamel is given; clinical cases of a hypoplasia of enamel of the teeth complicated by carious process are described, treatment methods are given.</p>
FEATURES OF ANTIVIRAL IMMUNITY IN PATIENTS WITH DAMAGE TO THE AUTONOMIC ПАРАСИМПТИЧЕСКИХ NODES OF THE HEAD
Authors: Николаева А. , Nikolaeva A. , Журавлев В. , Zhuravlev V. , Базарный В. , Bazarnyy V. 
Published: August 2018

<p>The immune status at 33 patients with defeat of vegetative parasympathetic knots of a virus etiology at the age from 27 till 64 years is investigated. From them the 19th woman and 15 men. The obtained data compared to indicators of healthy people. Patients addressed on neurostomatologic reception in versatile stomatologic policlinic of the Ural State Medical Academy on chair of surgical stomatology For the first time the structural analysis of a condition of various factors of antiviral protection is studied and carried out and the most significant disorders of immunity taking into account clinical data at patients with defeat of vegetative parasympathetic knots of a virus etiology are allocated, at the majority of patients immunological signs of a secondary immunoscarce condition with violations in humoral and cellular links of immunity, hyper reactance and insufficiency of systems of specific and nonspecific cytotoxicity.</p>
EXPERIENCE AND PERSPECTIVES OF BIOLOGICALLY INERT MATERIALS AND HIGH TECH AT THE STAGES OF THE COMPREHENSIVE TREATMENT OF PATIENTS WITH DEFECTS OF THE MANDIBLE
Authors: Асташина Н. , Astashina N. , Рапекта С. , Rapekta S. , Каченюк М. , Kachenyuk M. , Рогожников Г. , Rogozhnikov G. , Казаков С. , Kazakov S. 
Published: August 2018

<p>This article presents the results of treatment of patients with defects of the lower jaw. The possibilities and effectiveness of biologically inert materials – carbon composite «uglekon-m» (project carbulat) and titanium alloys on the stages of the complex treatment of patients with defects of the lower jaw.</p>A new implant system for replacing a defect of the lower jaw and plastic temporomandibular joint. When evaluating the characteristics of the basic implant system studied bond strength titanium element having carbon composite material. It was determined that the maximum strength of the titanium compound and the carbon component is observed at a sintering temperature of 1200°c. The study of the morphology of the transition layer shows that there is a tight abutment titanium particles to the carbon composite material, between the bundles no trace organizations.
LABORATORY EXAMINATION OF THE DIFFERENCES OF THE SECRETORY IMMUNE SYSTEM OF PATIENTS WITH ACUTE AND CHRONIC HERPES VIRUS INFECTION
Authors: Базарный В. , Bazarnyu V. , Журавлев В. , Zhuravlev V. , Мандра Ю. , Mandra Y. , Николаева А. , Nikolaeva A. , Ваневская Е. , Vanevskaya E. , Полушина Л. , Polushina L. 
Published: August 2018

Scientific evidence on the secretory immunity of the oral mucosa in herpetic infections and their impact on the clinical features of the disease are mixed. The purpose of our study isimmunological comparison of patients with acute and chronic herpes infection. Our clinical and laboratory examination was based on 33 patients with acute exacerbation of chronic recurrent herpetic stomatitis, 35 patients with head ganglionitis herpes viral etiology and 26 persons of the control group. The results indicate big violations of secretory immunity of patients with herpes infection (decreased IF-a in typical viral ganlionitis and elevated LF – for recurrent stomatitis).
ORGANIZATIONAL ASPECTS INFORMATIVITY MEDICAL EXAMINATION IN DAILY PRACTICE BY DENTIST
Authors: Шакуров В. , Shakurov V. 
Published: August 2018

<p>the article written by a scientific-journalistic style reflects the personal experience and observation of the author. «dental inspect» is a very important medical procedure. the article proposes an alternative approach and the way a kind of optimization of the technology for low-budget agencies dental profile. performing overview of many of the regulatory documents, the author tries to re-engage the attention of the colleagues to the versatility of an important stage of medical activities, which for various reasons cannot always be interpreted unambiguously in practice.</p>
CONSERVATIVE TREATMENT EXPERIENCE SEVERE PERIODONTITIS USING MODERN METHODS DESTRUCTION OF BIOFILM AND TECHNOLOGY PLASMOLIFTING
Authors: Буляков Р. , Bulyakov R. , Сабитова Р. , Sabitova R. , Гуляева О. , Gulyaeva O. 
Published: August 2018

<p>With the purpose of search of new effective methods of non-surgical treatment of chronic generalized severe periodontitis we carried out a complex conservative treatment of 27 patients, includes in addition to the standard therapy following combination: hardware remo val subgingival bio films and t e chnology Plasmolifting.</p><p>The absence of clinical signs of inflammation, stable level values hygienic indexes for the whole observation period and the reduction of the depth of periodontal pockets, confirmed the high efficiency of conservative therapy of severe periodontitis, developed by our therapeutic complex.</p>