bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dysfunctional endothelial progenitor cells in patients with Hodgkin’s lymphoma in complete remission
Authors: Wiessman Maya , Leshem Dorit , Yeshurun Moshe , Yavin Hagai , Iakobishvilli Zaza , Raanani Pia , Kornowski Ran , Lev Eli I. , Vaturi Mordehay 
Published: December 2018

AbstractBackgroundPatients with a history of Hodgkin's lymphoma (HL) are at increased long‐term risk of cardiovascular morbidity and mortality. Studies report an association between the pathophysiology of coronary artery disease (CAD) and levels of circulating endothelial progenitor cells (EPC), which play an essential role in vascular injury repair. The aim of the present study was to investigate the potential involvement of abnormal EPC level or function in the CAD risk of survivors of HL in remission.MethodsEPCs were isolated from peripheral blood samples drawn from 4 groups of patients aged 20‐50 years with no history of CAD: 17 patients with HL who had been in complete remission for at least 2 years, four newly diagnosed patients with HL before treatment, 28 patients with diabetes all attending a tertiary medical center, and 16 healthy individuals. Levels of EPC surface markers were measured by flow cytometry, and EPC function was evaluated by the number of colony‐forming units (CFUs) and MTT assay.ResultsLevels of circulating CD34(+)/VEGFR2(+) and CD133(+)/VEGFR2(+) were significantly higher in the newly diagnosed untreated patients with HL compared to the patients with HL in remission (P = 0.03 and P = 0.005, respectively), in the patients in remission compared to the patients with diabetes (P = 0.011 and P < 0.001, respectively), and in the patients in remission compared to the healthy individuals (P = 0.08 and P = 0.003, respectively). The analysis of cell viability and the number of colony‐forming units in the patients with HL in remission yielded significant differences from the healthy group (P = 0.005 and P < 0.001, respectively) but not from either the newly diagnosed patients with HL or the diabetic patients.ConclusionsThese results suggest that patients in complete remission of HL for at least 2 years have an abnormal EPC profile characterized by high circulating levels but attenuated function.
Hydrothermal Synthesis of a Novel Double‐Sided Nanobrush Co3O4 Catalyst and Its Catalytic Performance for Benzene Oxidation
Authors: Ma Xiuyun , Yu Xiaolin , Yang Xueqin , Lin Mengya , Ge Maofa 
Published: December 2018

AbstractA double‐sided nanobrush Co3O4 (Co3O4−B) catalyst was successfully prepared by a hydrothermal method for the first time, and Co3O4 rods (Co3O4−R), Co3O4 hexagonal plates (Co3O4−H) and Co3O4 double‐sided helianthus discs (Co3O4−D) were also synthesized through tuning the water/ethanol ratio. Among all of the as‐prepared catalysts, the Co3O4−B catalyst exhibited the best catalytic activity for benzene oxidation. The excellent catalytic performance could be attributed to the surface abundance Co3+ species, good low‐temperature reducibility and high number of lattice defects with substantial active oxygen species, which resulted from the unique structure of the double‐sided nanobrush. The stability and water tolerance tests demonstrated that the Co3O4−B catalyst displays excellent stability for benzene combustion, and the deactivation caused by water vapor is also reversible. It is concluded that the unique structure of the catalysts plays a crucial role in determining its catalytic oxidation performance.
Black Phosphorus Cytotoxicity Assessments Pitfalls: Advantages and Disadvantages of Metabolic and Morphological Assays
Authors: Fojtů Michaela , Balvan Jan , Raudenská Martina , Vičar Tomáš , Bouša Daniel , Sofer Zdeněk , Masařík Michal , Pumera Martin 
Published: December 2018

AbstractBlack phosphorus (BP) belongs to a group of 2D nanomaterials and nowadays attracts constantly increasing attention. Parallel to the growing utilization of BP nanomaterial increase also the requirements for the thorough comprehension of its potential impact on human and animal health. The aim of this study was to compare and discuss five assays commonly used for the cytotoxicity assessments of nanomaterials with a special focus on BP nanoparticles. A comprehensive survey of factors and pitfalls is provided that should be accounted for when assessing their toxicity and pointed to their inconsistency. BP might introduce various levels of interference during toxicity assessments depending on its concentration applied. More importantly, the BP toxicity evaluation was found to be influenced by the nature of assay chosen. These are based on different principles and do not have to assess all the cellular events equally. A commercial assay based on the measurement of protease activity was identified to be the most suitable for the BP toxicity assessment. Further, the benefit of time‐lapse quantitative phase imaging for nanomaterial toxicity evaluation was highlighted. Unlike the conventional assessments it provides real‐time analysis of the processes accompanying BP administration and enables to understand them deeper and in the context.
A Metal‐Organic‐Framework‐Derived g‐C3N4/α‐Fe2O3 Hybrid for Enhanced Visible‐Light‐Driven Photocatalytic Hydrogen Evolution
Authors: Liu Jing , Zhao Xiuxia , Jing Peng , Shi Wei , Cheng Peng 
Published: December 2018

AbstractAs one of the most efficient systems for photocatalytic hydrogen evolution, the Z‐Scheme system, consisting of different semiconductors with a reversible donor–acceptor pair, has attracted great attention. Considering the non‐toxicity and low cost of photocatalysts, a series of g‐C3N4/α‐Fe2O3 hybrids were rationally constructed based on the Z‐Scheme mechanism for the first time, using a metal‐organic framework template approach that can fine tune the compositions and properties of the hybrids. An optimized hybrid, g‐C3N4/α‐Fe2O3‐2, exhibited prominent photocatalytic water splitting performance with a visible light response. Under irradiation of visible light (λ>420 nm), the hybrid shows a high durability and superior hydrogen production rate of 2066.2 μmol g−1 h−1 from water splitting, which is approximately three times greater than that of bulk g‐C3N4 because of the effective separation of photo‐excited charge carriers by two narrow band gap semiconductors, tightly coupled with the Z‐Scheme structural feature.
Competing Crystallization between Lanthanide and Actinide in Acidic Solution Leading to Their Efficient Separation
Authors: Yin Xuemiao , Wang Yaxing , Li Xiaoyan , Xie Jian , Silver Mark A. , Chen Lanhua , Sheng Daopeng , Ji Guoxun , Chai Zhifang , Wang Shuao 
Published: December 2018

Summary of main observation and conclusionWe present a new method for generating europium oxalate compounds by decomposing of N‐methyl 2‐pyrrolidone in HNO3 media. The reaction exhibits high selectivity towards Eu3+ over UO22+, which suggests that these conditions could be applied to a selective crystallization based separation system for trivalent lanthanides and hexavalent actinides.
Enabling internal methods in passive optical network architecture for next generation OFDM‐PON supporting radio‐over‐fiber
Authors: Kishanlal M. Samayaraj Murali , Jawahar A. 
Published: December 2018

SummaryIn this study, it is focused on designing a novel architecture for Next Generation Orthogonal Frequency Division Multiplexing (NG‐OFDM), for Passive Optical Networks (PON). This is called as NGOF‐ROFPON (Next generation Optical Fiber – Radio over Fiber PON). In order to improve the efficiency in providing a seamless data transmission and to extend it to all terrains, the Radio‐Over‐Fiber (ROF) transmissions is applied among base stations and remote antennas. For a better decision making on the NGOF‐ROFPON, a simulation‐based experiment is carried out on both OFDM (Orthogonal Frequency Division Multiplexing) and its RF (Radio Frequency) output signals quality performance at receiver side is compared. By analyzing the system parameters in the simulation results collaboratively in optical broadband OFDM and RF OFDM over PON the best performance for a PON architecture is decided as a optimum method to the PON for next generation and referred as NGOF‐ROFPON. Moreover, from the simulation results, by selecting the best modulation technique, the spreading of the signal due to the downstream and upstream process is controlled and such signals are used in various frequency‐based RF signals over various distances in single mode fiber PON.
Room‐Temperature Synthesis of Germanium Oxide Nanofilaments and Their Potential Use as Luminescent Self‐Cleaning Surfaces
Authors: Saddiqi Naeem‐ul‐Hasan , Patra Debabrata , Seeger Stefan 
Published: December 2018

AbstractGermanium oxide nanofilaments (GNFs) have been synthesized under ambient conditions from the gas phase using germanium tetrachloride as a precursor. Non‐crystalline GNFs synthesized by this procedure are 1–10 μm in length and 80–110 nm in diameter applying Droplet Assisted Growth and Shaping (DAGS) Chemistry. The relative humidity has been adjusted at various values in order to demonstrate the crucial role of humidity in the gas phase for the nanofilament synthesis. The novel GNFs show a strong luminescence emission in the ultra‐violet and light blue region. In addition, a self‐cleaning and superhydrophobic properties could be introduced in the luminescent GNF nanofilaments by simple treatment with silane molecules.
3D Mapping of Gas Physisorption for the Spatial Characterisation of Nanoporous Materials
Authors: Joss Lisa , Pini Ronny 
Published: December 2018

AbstractNanoporous materials used in industrial applications (e. g., catalysis and separations) draw their functionality from properties at the nanoscale (1–10 Å). When shaped into a technical form these solids reveal spatial variations in the same properties over much larger length scales (1 μm–1 cm). The multiscale characterization of these systems is impaired by the trade‐off between sample size and image resolution that is bound to the use of most imaging techniques. We show here the application of X‐ray computed tomography for the non‐invasive spatial characterization of a zeolite/activated carbon adsorbent bed across three orders of magnitude in scale. Through the unique combination of gas adsorption isotherms measured locally and their interpretation by physisorption analysis, we determine three‐dimensional maps of the specific surface area and micropore volume. We further use machine learning to identify and locate the materials within the packed bed. This novel ability to reveal the extent of heterogeneity in technical porous solids will enable a deeper understanding of their function in industrial reactors. Such developments are essential towards bridging the gap between material research and process design.
Minimal residual disease and log‐reduction of plasma cells are associated with superior response after double autologous stem cell transplant in younger patients with multiple myeloma
Authors: Rossi Giovanni , Falcone Antonietta Pia , Minervini Maria Marta , De Cillis Giovanni Pio , De Waure Chiara , Sisti Leuconoe Grazia , Giambra Vincenzo , Valente Daniela , Chiello Vincenzo , Scalzulli Potito Rosario , Carella Angelo Michele , Cascavilla Nicola 
Published: December 2018

BackgroundOptimization of chemotherapy regimens in the treatment of multiple myeloma (MM) has led to increase the frequency of cases with complete response (CR). Nonetheless, many MM patients still experience relapse, suggesting that CR represents a suboptimal response criteria, and that new therapeutic strategies are needed after single transplant. However, the role of double autologous stem cell transplant (ASCT) as new adjunctive strategy remains to be elucidated. Indeed, we investigated the role of minimal residual disease (MRD) and log‐reduction of plasma cells (PCs) as predictors of outcome and in quantifying the degree of tumor reduction after any ASCT.MethodsMRD and log‐reduction were assessed by a six‐color flow cytometry (FC) at different time‐points: post induction, post first‐, and post‐second ASCT.ResultsA significant difference was evidenced among the three time points for both log‐reduction (P < 0.001) and MRD (P = 0.005). MRD levels after double ASCT were lower than MRD levels achieved after single ASCT (P = 0.005) and after induction (P < 0.001). Frequency of MRD positive patients after double ASCT was significantly lower rather than after the first ASCT (P = 0.008) and after induction (P = 0.004). Interestingly, a significant reduction of PFS was observed in patients with an unfavorable‐risk cytogenetic (P < 0.001) and patients with MRD over 0.01% (P = 0.001) as well as log‐reduction lower than 2.57 (P = 0.018) after double ASCT.ConclusionsOur results show that a better clearance of myeloma cells is observed after the double ASCT, and a longer PFS is associated with a lower MRD. © 2018 International Clinical Cytometry Society
Valence matters: An electrophysiological study on how emotions influence cognitive performance in children
Authors: Abdul Rahman Aishah , Wiebe Sandra A. 
Published: December 2018

AbstractEmotional stimuli have been found to influence cognitive performance in children, but it is not clear whether this effect varies with the cognitive demands of the task. In this study, we examined how emotional expressions influenced cognitive performance and event‐related potentials (ERPs) in early and middle childhood under varying cognitive control demands. Two groups of children (4.5–6.0 and 7.0–8.5 years) completed a modified flanker task where the stimuli were faces displaying task‐irrelevant emotional expressions. Emotional influence varied depending on emotional valence: Accuracy was greater for happy targets, while response time and N2 latency were longer for angry targets. In younger children only, angry targets elicited a larger late frontal negativity. Cognitive control demands did not modulate the effect of emotions on behavioral performance or ERPs, contrasting with findings in adults. Findings are discussed in relation to the dual competition model and previous work demonstrating a positivity bias in children.
Identification of the parasitoid community associated with an outbreaking gall wasp,Zapatella davisae, and their relative abundances in New England and Long Island, New York
Authors: Davis Monica J. , Andersen Jeremy C. , Elkinton Joseph 
Published: December 2018

AbstractGall wasps (Hymenoptera: Cynipidae) are phytophagous insects that often go unnoticed; however, when they are introduced to a new area or released from their natural enemies, they have the capacity to outbreak and cause extensive foliar damage. One such outbreaking pest,Zapatella davisae(Cynipidae: Cynipini), causes significant damage and mortality to black oak,Quercus velutina, in the northeastern United States. In this study, we aimed to identify the parasitoid community associated withZ. davisae, compare differences in percent parasitism ofZ. davisaein Cape Cod and Long Island, and determine which parasitoid species contribute most to parasitism in each region. From both locations, we reared parasitoids, identified morphological groups, analyzed percent parasitism rates for each group, and used DNA barcoding to provide species‐level identifications. On Long Island, there was nearly 100% parasitism in 2015 followed by a near total collapse of the population in 2016. In contrast, parasitism rates were lower and remained consistent on Cape Cod between 2015 and 2016, which may explain the greater canopy damage observed in that region. Species of Sycophila were the dominant parasitoids, with one speciesSycophilanr.novascotiaerepresenting ~65% of reared parasitoids from Long Island, and two species ofSycophila(S. nr. novascotiaeandS. foliatae) with near equal representations on Cape Cod. In order to manage an insect pest, it is important to understand factors that influence its mortality and survival. An understanding of how these infestations progress overtime can help predict the impact that newer infestations in Nantucket, MA, and coastal Rhode Island will have on black oak populations and will aid in the management of this rapidly spreading gall wasp pest.
Genesis of the Zhunsujihua porphyry Mo deposit in the Erenhot‐East Ujimqin metallogenic belt, Inner Mongolia, China: Evidence from geology, fluid inclusions, and isotope systematics
Authors: He Lin‐Yang , Wang Yin‐Hong , Liu Jia‐Jun , He Ming‐Yue , Yao Yuan , Xian Xue‐Chen 
Published: December 2018

The newly discovered Zhunsujihua porphyry Mo deposit is located in the south‐western part of the Great Hingan Range, north‐east China. Molybdenum mineralization generally presents as veins or disseminations hosted in granitic intrusions, and multiple‐stage hydrothermal activity has resulted in potassic, phyllic, and sericitic alteration. The mineralization process can be divided into four stages, that is, quartz–K‐feldspar ± pyrite veinlets in stage I, quartz–molybdenite veinlets in stage II, quartz–polymetallic sulfide veinlets in stage III, and barren quartz–calcite veins in stage IV. Four types of fluid inclusions can be distinguished by petrography in hydrothermal quartz, including liquid‐rich two‐phase, vapour‐rich two‐phase, pure gaseous, and pure liquid inclusions, but quartz in stage I contains all types of fluid inclusions. The homogenization temperatures in quartz of stages I, II, III, and IV vary from 300°C to 520°C, 230°C to 410°C, 170°C to 260°C, and 136°C to 227°C, with salinities of 4.18–13.30 wt.% NaCl equiv., 2.07–11.10 wt.% NaCl equiv., 1.74–8.95 wt.% NaCl equiv., and 0.70–5.71 wt.% NaCl equiv., respectively. The ore‐forming fluids in this deposit are characterized by high temperature and intermediate to low salinity belonging to an H2O–NaCl system. δ18Oquartz values of quartz from stages I to IV range from +5.5‰ to +10.1‰, with the calculated δ18Ofluid values ranging from –6.7‰ to +6.3‰, and the δD values of fluid inclusion waters in quartz ranging from –118‰ to –102‰. The δ34S values of pyrite and molybdenite from different ore stages range from 3.8‰ to 6.8‰ with an average of 5.1‰. Pyrite and molybdenite samples in the deposit have 206Pb/204Pb ratios of 18.394 to 18.766, 207Pb/204Pb ratios of 15.580 to 15.694, and 208Pb/204Pb ratios of 38.309 to 38.942. All these observations reveal that the hydrothermal fluids of the Zhunsujihua porphyry Mo deposit have a dominantly magmatic signature with an input of meteoric water during the carbonate stage, and the ore‐forming components (metal and sulfur) were sourced from a greater magmatic source and some upper crustal materials.
Clinical significance and peculiarities of succinate dehydrogenase B and hypoxia inducible factor 1α expression in parasympathetic versus sympathetic paragangliomas
Authors: Bernardo‐Castiñeira Cristóbal , Sáenz‐de‐Santa‐María Inés , Valdés Nuria , Astudillo Aurora , Balbín Milagros , Pitiot Ana S. , Jiménez‐Fonseca Paula , Scola Bartolomé , Tena Isabel , Molina‐Garrido María‐José , Sevilla María‐Agustina , Beristein Elena , Forga Lluís , Villabona Carles , Oriola Josep , Halperin Irene , Suarez Carlos , Chiara María‐Dolores 
Published: December 2018

AbstractBackgroundSuccinate dehydrogenase subunit B (SDHB) immunohistochemistry was considered a valuable tool to identify patients with inherited paraganglioma/pheochromocytoma (PGL/PCC). However, previous studies jointly analyzed 2 related but clinically distinct entities, parasympathetic head and neck paragangliomas (HNPGLs) and sympathetic PCCs/PGLs. Additionally, a role for hypoxia inducible factor‐1α (HIF‐1α) as a biomarker for succinate dehydrogenase (SDHx)‐mutated tumors has not been studied. Here, we evaluated the utility of SDHB/HIF‐1α proteins in HNPGLs and PCCs/PGLs as clinically useful biomarkers.MethodsThe SDHB/succinate dehydrogenase subunit A (SDHA)/HIF‐1α immunohistochemistry analysis was performed in 158 genetically defined patients.ResultsSimilarly to PCCs/PGLs, SDHB immune‐negativity correlated with SDHx‐mutations in HNPGLs (P < .0001). The HIF‐1α stabilization was associated with SDHx‐mutations in HNPGLs (P = .020), not in PCCs/PGLs (P = .319). However, 25% of SDHx‐HNPGLs lacked HIF‐1α positive cells.ConclusionAs in PCCs/PGLs, SDHB immunohistochemistry in HNPGLs is a valuable method for identification of candidates for SDHx‐genetic testing. On the contrary, although SDHx mutations may favor HIF‐1α stabilization in HNPGLs, this is not a clinically useful biomarker.
Serum matrix metalloproteinase 8 and tissue inhibitor of metalloproteinase 1: Potential markers for malignant transformation of recurrent respiratory papillomatosis and for prognosis of laryngeal cancer
Authors: Pakkanen Pihla P. , Aaltonen Leena‐Maija , Sorsa Timo A. , Tervahartiala Taina I. , Hagström Jaana K. , Ilmarinen Taru T. 
Published: December 2018

AbstractBackgroundBiomarkers that could predict malignant transformation of recurrent respiratory papillomatosis (RRP) would be useful in patient follow‐up. We investigated whether serum matrix metalloproteinase 8 (MMP‐8) and tissue inhibitor of metalloproteinase 1 (TIMP‐1) could predict malignant transformation of RRP and whether they associate with survival in laryngeal squamous cell carcinoma (LSCC) without preexisting RRP.MethodsWe analyzed serum MMP‐8 (S‐MMP‐8) and serum TIMP‐1 (s‐TIMP‐1) in 114 patients: 55 were treated for RRP and 59 for LSCC without preexisting RRP. Five patients with RRP developed LSCC during follow‐up.ResultsElevated S‐MMP‐8 level in RRP was associated with malignant transformation (P = .01). Compared to patients with RRP, S‐MMP‐8 in patients with LSCC was significantly higher (P < .001). Increased S‐TIMP‐1 level in LSCC was associated with poor overall survival (P = .02) and recurrence‐free survival (P = .05).ConclusionIn RRP, high S‐MMP‐8 may predict malignant transformation. In LSCC, elevated S‐TIMP‐1 is connected to poor survival.
Nonmelanoma skin cancer of the head and neck region in solid organ transplant recipients
Authors: Ritter Amit , Bachar Gideon , Feinmesser Raphael , Shpitzer Thomas , Popovtzer Aron , Rabinovics Naomi 
Published: December 2018

AbstractBackgroundNonmelanoma skin cancers (NMSC) are the most common malignancies in solid organ recipients. We investigated the incidence, clinical features, and outcome of solid organ recipients with NMSC of the head and neck.MethodsA retrospective chart review was conducted for solid organ recipients who were treated from 1992 to 2015 and who developed NMSC of the head and neck.ResultsOf 3339 organ recipients, 259 patients developed 697 head and neck NMSC. Squamous cell carcinoma was the most common malignancy (55%). The overall 5‐year and 10‐year survival was 68% and 45%. Kidney recipients had better survival outcome than other organ recipients (10 vs 7 years). Advanced‐stage cancers (10%), aggressive patterns of tumors (21%), and treatment with Prograf and Cellcept were associated with increased disease‐specific mortality.ConclusionSolid organ transplant increases the risk of NMSC of the head and neck. Aggressive tumors decrease patient survival and warrant more decisive and multidisciplinary approach.