bluuebunny/crossref_metadata_2025_split huggingface dataset:
Vaccination: a look at the social representations of Brazilian children
Authors: de Gaspi Suelen , Magalhães Júnior Carlos Alberto de Oliveira , Tracana Rosa Branca , Schneider Eduarda Maria , Carvalho Graça S. 
Published: December 2024

IntroductionThe pandemic caused by COVID-19 has accentuated the debate on the need for vaccination and called into question the need to increasingly bring this topic, which is widely disseminated in the scientific world, to school classes at all schooling phases. In this scenario, science education plays a key role in disseminating knowledge about the importance of vaccination and the impacting factors of a lack of immunization. In order to better understand this movement, it is necessary to understand the representations of individuals as a way of broadening paths to change this scenario.ObjectivesThis study aimed to identify and analyse Brazilian primary school children’s social representations of vaccination.MethodsUsing the free word recall technique, the term “vaccination” was applied to evoke children’s ideas. The analysis of co-occurrences of evocations permitted us to identify their representations’ centrality.ResultsThe results showed that the centralizing elements guiding these children’s social representations were “needle,” “pain,” and “health center.”ConclusionThese results show the need to prevent the phobia of needles that arises in the first vaccination experiences and reinforce the importance of discussing the subject of vaccination in science teaching. This issue is even more critical, given the spread and impact of “fake news” on social media. There is an increasing need to emphasize the importance of vaccination, not only as a factor of individual protection but also as a commitment to collective health. This study also showed that the school, as usual, must become an ally in tackling this reality with children and their families.
Availability of eye health interventions in basic schools in a Ghanaian municipality
Authors: Adzaho Christopher Senyo , Appiah-Brempong Emmanuel , Acheampong Princess Ruhama , Ekutor Ernest 
Published: December 2024

IntroductionGlobally, 19 to 22 million children are visually impaired. A huge number of children therefore will not be able to learn effectively even if the best educational institutions are made available to them. This ultimately leaves a potential negative effect on their quality of life, educational opportunities and livelihoods. School health programs (SHPs) present a unique opportunity to provide comprehensive eye health services to children. This study assessed the availability of School Eye Health Programs (SEHPs) in a municipality in Ghana.Design and methodsIn a cross-sectional study, semi-structured questionnaires and interview guides were used to collect data from 60 head teachers, 17 school health coordinators, and 7 key health workers.ResultsNo school in the municipality had a comprehensive SEHP being implemented. However, over 60% of schools had at some point introduced at least one component of SEHP, mainly Vitamin A supplementation and vision screening. Community and Public Health Nurses are the commonly used human resource for such programs. There were no available guidelines for program implementation and no systems in place for ensuring follow-up visits and provision of spectacles to those with refractive errors. Key barriers identified included the lack of financial resources and adequately trained personnel.ConclusionComprehensive school eye health programs are unavailable in the study area and there is an urgent need for their implementation to avert the potential adverse effects of vision impairment on the education of children.
Energy efficiency and system complexity analysis of CNN based hybrid precoding for cell-free massive MIMO under terahertz communication
Authors: Abose Tadele A. , Mekonen Yitbarek A. , Assefa Binyam G. , Gudeta Naol W. 
Published: December 2024

The integration of terahertz (THz) communication with cell-free massive multiple-input multiple-output (CFMM) systems presents a promising strategy to enhance energy efficiency and reduce system complexity in future wireless networks. However, this integration faces significant challenges, such as dynamic and unpredictable channel behavior. Traditional channel estimation techniques are inadequate for handling these dynamic conditions. To address these issues, a convolutional neural network (CNN)-based hybrid precoding scheme is proposed for CFMM systems operating at THz frequencies. This method leverages CNN to predict optimal precoding weights, significantly improving the adaptability of hybrid precoding. The CNN-based model not only mitigates pilot contamination (PC) but also enhances channel estimation by capturing temporal and spatial dynamics. Simulation results indicate that the CNN-based approach achieves superior energy efficiency and lower system complexity compared to conventional techniques. At a signal-to-noise ratio (SNR) of 30 dB, it achieves 1.2 bits per joule and reduces system complexity to 1,400 FLOPs, demonstrating better scalability and resource optimization. These findings highlight the potential of CNN-based hybrid precoding to revolutionize THz communication in next-generation wireless networks by optimizing energy efficiency and system complexity.
Comparison of 6 cycles of isatuximab with lenalidomide, bortezomib and dexamethasone (I-VRd) versus 3 cycles of I-VRd followed by one cycle of high-dose melphalan in newly diagnosed low-risk multiple myeloma. Protocol for a multicenter, prospective, randomized, phase II clinical trial (ELIAS-Trial)
Authors: Leitner Theo , Shumilov Evgenii , Schwitlick Christina , Koch Raphael , Hamm Franziska , Högner Marion , Bassermann Florian , Weisel Katja , Einsele Hermann , Kortüm Martin , Rasche Leo , Görner Martin , Wegehenkel Kai , Knop Stefan , Krönke Jan , Nogai Axel , König Inke R. , Vens Maren , Horn Kay , von Bubnoff Nikolas , Khandanpour Cyrus 
Published: December 2024

Newly diagnosed multiple myeloma patients who are eligible for transplant usually receive several induction cycles of therapy, followed by one or two cycles of high-dose melphalan and autologous stem cell transfusion. In myeloma patients, high-dose melphalan improves overall survival and progression-free survival. However, melphalan exposure increases the risk of secondary malignancies and may lead to the transformation of residual myeloma cells into more aggressive clones, which may accelerate relapse. It remains to be determined whether low-risk patients also derive additional benefit from high-dose melphalan therapy compared with less toxic regimens. Here we publish the study protocol of a multicenter, interventional, controlled, randomized, prospective and open-label phase II trial to investigate whether patients with a low-risk profile (R-ISS stage I, characterized by a low tumor burden and the absence of negative cytogenetic findings or elevated LDH levels) and a standard-risk gene expression profile (using the SKY92 GEP assay) can be sufficiently treated with intensified consolidation regimens without prior high-dose melphalan chemotherapy. The primary objective is to assess whether three cycles of isatuximab, bortezomib, lenalidomide and dexamethasone (I-VRd) followed by stem cell apheresis and three additional cycles of I-VRd will result in a non-inferior rate of complete remission (CR) combined with MRD-negativity at week 40 after the start of induction therapy compared to three cycles of I-VRd followed by standard of care treatment (such as stem cell apheresis, high-dose melphalan, and autologous stem cell transplantation). We hypothesize that this approach could reduce toxicity, cost of treatment and the likelihood of the development of a more malignant plasma cell clone, while improving overall survival (OS) and progression-free survival (PFS) in newly diagnosed low risk myeloma patients.EU Trial Number2022-500453-16-00, https://clinicaltrials.gov/study/NCT05665140, identifier NCT05665140. Registration Date: 21.07.2022.
Rotations of teeth—a systematic review
Authors: Parthiban Ramya , Kailasam Vignesh , Venkatasamy Nivetha Shree 
Published: December 2024

BackgroundRotations are frequently evaluated through various assessment methods of crowding and arch dimension, with relatively few studies discussing the extent or direction of rotations and even fewer addressing the reliability of such assessments. This systematic review aims to comprehensively analyze existing classification systems for rotated teeth and assess rotation in anterior and posterior teeth, its clinical applicability, and its impact on retention and relapse.Search methodsTwo investigators conducted a comprehensive search in six databases, namely, PubMed, Scopus, Ovid, LILACS, Web of Science, and Cochrane CENTRAL, up to 28 March 2024. No specific start date was defined to ensure the inclusion of all relevant studies from the inception of each database, maximizing the comprehensiveness of our review. The search criteria included retrospective studies and the inclusion criteria were patients who were assessed for rotation in any age group. The exclusion criteria were patients who had undergone orthodontic treatment, who had fractured restorations or crowns, or who had any other tooth anomaly.Data collection and analysisIn total, 10 studies satisfying the inclusion criteria were included and 9 provided quantitative outcomes for the rotation of various teeth, while the remaining study offered qualitative results. The risk of bias assessment was performed with the help of the Newcastle–Ottawa quality assessment tool.ResultsThe skeletal Class II and Class III groups exhibited similar average positions of the first molar. Upper molar rotation was primarily observed in dental Class II patients, with a higher mesial rotation angle of 78.6°. Only one study measured the rotation for all permanent teeth. Seven studies used the mid-palatal raphe as the reference line for measuring molar rotation. No gender differences were found. It was found that there was no statistical significance in the mean values of molar rotation for the right and left sides as well as the maxillary and mandibular arches. The incisors demonstrated the highest degree of rotation (7.4°–20.2°), while the premolars and canines exhibited a slightly lower degree of rotation (3.3°–9.2°). In contrast, the molars displayed the lowest degree of rotation (0.8°–7.4°).ConclusionAfter reviewing all the studies, it was found that there is no adequate classification system to assess the rotation of anterior teeth and mandibular teeth. A universally accepted classification of tooth rotation, including a common reference line, is needed. The existing systems for posterior teeth need to be standardized and have a clinical utility to be widely accepted.Systematic Review Registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42024524654, PROSPERO (CRD42024524654).
Vascular reconstructions in living donor kidney transplantation: a single-center experience over the last 17 years
Authors: Roth Nadina , Kalteis Manfred , Krause Axel , Rösch Christiane Sophie , Huber Jürgen , Enkner Wolfgang , Haller Maria , Cejka Daniel , Függer Reinhold , Biebl Matthias 
Published: December 2024

IntroductionIn living donor kidney transplantation (LDKT), vascular anastomosis is more difficult due to missing arterial patches and shorter renal veins. The surgical challenge is even more demanding in kidneys with multiple arteries. Although renal transplantation is feasible in most cases of complex donor vascular anatomy and similar results compared with standard LDKT are reported, the discussion on potentially increased complication rates and graft function continues. This prompted us to review our results of LDKT with multiple renal artery (MRA) grafts with a special concentration on complications and long-term function.Patients and methodsWe reviewed the records of all LDKT in our center from the beginning of the program in 2005 until 2022 for arterial vascular reconstructions. The cohort was divided into two groups: transplantation with vascular reconstruction (VR) and standard transplantation. These groups were compared for operative parameters and short- and long-term results.ResultsFrom 2005 to 2022, 211 LDKT were completed in our unit. In 32 (15.2%), a VR was performed, including single ostium side-to-side anastomosis, end-to-side anastomosis, patch reconstruction, and vein interposition. There was no significant difference in operative time (169 min vs. 180 min; p = 0.118) and time for anastomosis (28 min vs. 26 min; p = 0.59) between both groups. Postoperative complications (5.7% vs. 7.4%; p = 0.72) were not significantly different. During the follow-up period (110 months, range 10–204), the risk of organ loss was comparable after VR (13.625% vs. 11.56% p = 0.69).ConclusionIn LDKT, arterial vascular reconstructions for kidneys with MRA provide similar results compared to grafts with a single renal artery (SRA). Short- and long-term results are comparable with standard procedures.
Serum symmetric dimethylarginine concentrations in enalapril- or telmisartan-treated dogs with proteinuric chronic kidney disease
Authors: Nasr Amirah , Lourenço Bianca N. , Coleman Amanda E. , Bartges Joseph W. 
Published: December 2024

IntroductionRenin-angiotensin-aldosterone system inhibition (RAASi) reduces intraglomerular pressure and is a standard therapy for dogs with proteinuric chronic kidney disease (CKD). RAASi can acutely decrease glomerular filtration rate (GFR); however, its effects on the marker of GFR serum symmetric dimethylarginine (SDMA) concentration in dogs have not been specifically evaluated. The objective of this study was to evaluate changes, relative to pretreatment values, in serum SDMA concentrations in dogs with proteinuric CKD receiving RAASi therapy.MethodsThis retrospective study used banked samples from 29 dogs with proteinuric CKD treated with enalapril (0.5 mg/kg PO q12h; n = 16) or telmisartan (1 mg/kg PO q24h; n = 13) alone (n = 22) or in combination with amlodipine if severely hypertensive (n = 7). Serum SDMA, creatinine, and urea nitrogen (SUN) concentrations were measured before and 7 and 30 days after starting RAASi. Percentage and absolute changes in these biomarkers were calculated for each dog and time point. A linear mixed model was used to test whether changes significantly differed from zero (α &lt; 0.05).ResultsOverall, mean ± SEM Day 7 and 30 percentage change in SDMA were  − 4.8 ± 3.6% and  − 3.2 ± 3.4%, respectively; in creatinine were 7.4 ± 3.3% and 3.0 ± 3.1%, respectively; and in SUN were 22.1 ± 6.8% and 16.7 ± 6.2%, respectively. Mean changes varied according to whether all dogs, those on RAASi alone, or those co-treated with amlodipine were evaluated. In dogs receiving RAASi alone, at day 7, there were significant mean percentual increases in creatinine (9%; p = 0.023) and SUN (23%; p = 0.005), but SDMA was unchanged. In dogs co-treated with amlodipine, a significant absolute decrease in mean SDMA (−2.29 μg/dL; p = 0.026) occurred at days 7 and 30, while mean creatinine was unchanged and mean SUN increased.DiscussionProteinuric dogs receiving RAASi had low-magnitude changes in serum SDMA and creatinine, and moderate-magnitude changes in SUN concentrations. The direction of change in SDMA did not consistently match that of creatinine and SUN.
Evaluation of Selected Folk Herbs on the Fertility of Sprague Dawley Male Rats: Biochemical, Histological, and Molecular Investigations
Authors: Khalaf Rana R. , Khazaal Salma , Abouzeinab Noura S. , Khalil Mahmoud I. 
Published: December 2024

Scientists have shown great interest in traditional plant extracts, particularly Lepidium sativum (LS), Origanum majorana (OM), Ferula hermonis (FH), and Eruca sativa (ES), which are frequ ently used to improve health. Recently, attention has been directed toward their influence on spermatogenesis and male fertility. Hence, the objective of this study was to explore their impact on male rats’ fertility. Antioxidant activity and total phenolic content (TPC) were determined, along with the identification and quantification of phenolic compounds. Oral administration of aqueous extracts was performed individually or as a mixture (MIX) at a dose of 100 mg/kg in 28 male Sprague Dawley rats over a 60-day period. Organ weight, sex hormone concentrations, sperm parameters, oxidative stress markers, histological and morphometric analysis, and protein expression levels were investigated. OM and MIX showed the highest TPC and antioxidant activities, and MIX possessed the highest polyphenolic constituents. Elevated serum testosterone, epididymal sperm concentration, testes glutathione levels, and histomorphometric parameters were manifested in all groups, especially in MIX. MIX group also displayed elevated levels of vimentin, protein kinase B, and mTOR expression in the testes, complemented by declined expression of Phosphatase and Tensin Homolog (PTEN). In conclusion, these findings propose that these extracts, especially MIX followed by OM, enhance fertility by stimulating spermatogenesis.
Why pelletizing hops? A comparison of physical-chemical properties between powder and pellets
Authors: Ceola Duan , Savaris Ricardo Francalacci 
Published: December 2024

Why was the work done: The use of pellets was introduced as a method to reduce volume and increase shelf-life of hop plants (Humulus lupulus). There is no evidence that pellets retain better hop qualities compared to powder. The objective of this study was to compare the physical-chemical properties of hops in flower, powder, and pellet forms. How was the work done: Hop species (Cascade, Northern Brewer, and Comet) were analyzed in triplicate using chromatography, conductometric titration, steam distillation, and gravimetry, for essential oil content, alpha-acid percentage, and humidity, respectively. What are the main findings: A consistent reduction in essential oil content, alpha-acid percentage, and humidity was observed as the degree of hop processing increased from flower to powder to pellet. (p<0.0001, ANOVA and Tukey's post hoc test). Why is the work important: These results provide evidence that the pelleting process reduces key compounds like essential oils and alpha acids that contribute to hop quality for beer production when compared to the powder presentation. Eliminating the pelleting process could potentially reduce some production costs associated with hop processing. Pelleting requires additional equipment and energy, which contributes to overall production expenses.
МЕТОДИКА ПРОПОРЦИОНАЛЬНЫХ СЛОЕВ ПРИ КОМПЛЕКСНОЙ ИНТЕРПРЕТАЦИИ СЕЙСМИЧЕСКИХ И СКВАЖИННЫХ ДАННЫХ
Authors: И.А. Селетков , Д.А. Белышев 
Published: December 2024

Атрибутный анализ является одним из устоявшихся подходов при комплексной интерпретации сейсмических и скважинных данных, а также при прогнозе фильтрационно-емкостных свойств (ФЕС) геологического разреза. Однако наряду со своими преимуществами обладает и рядом неопределенностей. Одна из них – это неоднозначность корректного определения временного окна для расчета сейсмических атрибутов. В статье предлагается подход автоматизированного варианта методики пропорциональных слоев, который позволяет автоматически перебирать все возможные варианты временных окон для расчета атрибутов и по критерию наилучшего коэффициента корреляции между прогнозным параметром и сейсмическим атрибутом выбирать оптимальное решение для прогноза с использованием одномерной линейной регрессии. Предлагаемый подход продемонстрирован на реальном сейсмическом проекте.
Attribute analysis is one of the well-established approaches for the complex interpretation of seismic and borehole data and the prediction of the properties of a geological section. However, along with its advantages, it also has a number of uncertainties. One of them is the ambiguity of correctly defining the time window for calculating seismic attributes. The article proposes an approach of an automated version of the proportional layers technique, which allows you to automatically sort through all possible time windows for calculating attributes and, according to the criterion of the best correlation coefficient between the forecast parameter and the seismic attribute, choose the optimal solution for forecasting using one-dimensional linear regression. The proposed approach is demonstrated on a real seismic project.
ИЗУЧЕНИЕ МЕЖСКВАЖИННОГО ПРОСТРАНСТВА С ПОМОЩЬЮ АТРИБУТНОГО АНАЛИЗА СЕЙСМИЧЕСКИХ ДАННЫХ И МАШИННОГО ОБУЧЕНИЯ НА ПРИМЕРЕ МЕСТОРОЖДЕНИЯ В НЕНЕЦКОМ АВТОНОМНОМ ОКРУГЕ
Authors: И.С. Заключнов , И.С. Путилов 
Published: December 2024

Рассмотрены результаты изучения межскважинного пространства пермских терригенных отложений на примере газонефтяного месторождения в Ненецком автономном округе (НАО) с применением современных интерпретационных инструментов. Определение зависимостей между сейсмическими атрибутами и значениями эффективных толщин выполнялось с помощью современных математических алгоритмов. Особенности строения речной палеосети и тектоники определены с помощью спектральной декомпозиции и усовершенствованного атрибута когерентности.
The article considers the results of studying the inter-well space of Permian terrigenous deposits on the example of a gas and oil field in the Nenets Autonomous Okrug (NAO) using modern interpretation tools. The aim of the work is to find dependencies between seismic attributes and values of effective thicknesses using modern mathematical algorithms and to emphasize the tectonics and structural features of the river paleo valley.
ПОДАВЛЕНИЕ ПОМЕХ ГЕОЛОГИЧЕСКОЙ ПРИРОДЫ ПРИ ТРАНСФОРМАЦИИ РЕГИОНАЛЬНЫХ АНОМАЛИЙ СИЛЫ ТЯЖЕСТИ
Authors: А.С. Долгаль , В.И. Костицын , П.Н. Новикова , Н.В. Рыжов , В.В. Хохлова 
Published: December 2024

Рассматривается методика трансформации гравитационного поля больших территорий с использованием эквивалентных источников (точечных масс). Предлагается предварительное геологическое редуцирование аномалий Буге с использованием глобальной модели строения земной коры CRUST1. Для определения эффективной плотности моделируемых слоев проводится решение линейной обратной задачи гравиметрии. С целью минимизации краевых эффектов используется двухуровенная аппроксимационная конструкция с разрежением сети задания значений поля за пределами площади исследований. Приведен пример применения данной методики трансформации с подавлением геологических помех в пределах листа О-40 (Пермь), ограниченного координатами 56–60° с.ш., 54–60° в.д.
A method for transforming the gravitational field of large territories using equivalent sources (point masses) is considered. A preliminary geological reduction of the Bouguer anomalies is proposed using the global model of the crustal structure CRUST1. To determine the effective density of the simulated layers, a linear inverse gravimetry problem is solved. In order to minimize edge effects, a two-level approximation structure is used with rarefaction of field values outside the study area. An application example of this transformation technique with the suppression of geological noise within map sheet O-40 (Perm) within the coordinates 56°–60° N, 54°–60° E is given.