bluuebunny/crossref_metadata_2025_split huggingface dataset:
p120-catenin regulates WNT signaling and EMT in the mouse embryo
Authors: Hernández-Martínez Rocío , Ramkumar Nitya , Anderson Kathryn V. 
Published: August 2019

Significancep120-catenin, an armadillo-repeat protein, regulates the stability of classical cadherins, but its cellular functions in vivo remain unclear. Here, we show that genetic deletion ofp120-cateninin the mouse embryo causes developmental arrest at midgestation with a bifurcation of the posterior body axis. This morphological defect is associated with an expanded primitive streak, p53-dependent cell death, and abnormal mesoderm migration. The expanded primitive streak inp120-cateninmutants is caused by ectopic activation of the canonical WNT signaling pathway, and the bifurcation of the axis is associated with accumulation of mesoderm cells that migrate without direction. The functions of p120-catenin in the early mouse embryo are likely to be important during other developmental epithelial-to-mesenchymal transitions (EMTs) and in tumor metastasis.
Disruption of IRE1α through its kinase domain attenuates multiple myeloma
Authors: Harnoss Jonathan M. , Le Thomas Adrien , Shemorry Anna , Marsters Scot A. , Lawrence David A. , Lu Min , Chen Yung-Chia Ariel , Qing Jing , Totpal Klara , Kan David , Segal Ehud , Merchant Mark , Reichelt Mike , Ackerly Wallweber Heidi , Wang Weiru , Clark Kevin , Kaufman Susan , Beresini Maureen H. , Laing Steven T. , Sandoval Wendy , Lorenzo Maria , Wu Jiansheng , Ly Justin , De Bruyn Tom , Heidersbach Amy , Haley Benjamin , Gogineni Alvin , Weimer Robby M. , Lee Dong , Braun Marie-Gabrielle , Rudolph Joachim , VanWyngarden Michael J. , Sherbenou Daniel W. , Gomez-Bougie Patricia , Amiot Martine , Acosta-Alvear Diego , Walter Peter , Ashkenazi Avi 
Published: August 2019

Significance
Multiple myeloma (MM) is a lethal malignancy arising from plasma cells. MM cells experience endoplasmic reticulum (ER) stress due to immunoglobulin hyperproduction. The ER-resident sensor IRE1α mitigates ER stress by expanding protein-folding and secretion capacity, while supporting proteasomal degradation of ER misfolded proteins. IRE1α elaborates these functions by deploying a cytoplasmic kinase–RNase module to activate the transcription factor XBP1s. Although IRE1α has been implicated in MM, its validity as a potential therapeutic target—particularly as a kinase—has been unclear. Using genetic and pharmacologic disruption, we demonstrate that the IRE1α–XBP1s pathway is critical for MM tumor growth. We further show that the kinase domain of IRE1α is an effective and safe potential small-molecule target for MM therapy.
Numerical prediction of hill charts of Francis turbines
Authors: Nordvik Andreas , Iliev Igor , Trivedi Chirag , Gunnar Dahlhaug Ole 
Published: August 2019

Abstract
This present work compares numerically predicted hill chart to experimental measurements of a Francis turbine. The main objective is to create a model for recreating hill charts using computational fluid dynamics (CFD). Accurate prediction of hill charts are useful in the design stage of production and may result in a more efficient runner. The primary focus is the prediction of efficiency and investigation of possible simplifications without loss in accuracy. By using steady-state simulations, preliminary tests were made on four different meshes, and two different turbulence models, namely the standard k – ε model and the shear stress transport model. Simplifications of geometry have been tested to investigate if the simulation time can be reduced without sacrificing accuracy. Numerical simulations of 132 operating points were carried out. The efficiency was predicted with the maximal difference from measured values of 6.93%.
Regression classifier in adaptive technical vision system
Authors: Shmyrin A , Mishachev N , Kavygin V , Kuznetsov A 
Published: August 2019

Abstract
The article deals with the problem of constructing a classifier for a set of n physical objects encoded by vectors of the space

ℝ
N

. In this well-known problem of pattern recognition, we are interested in the case when the number of factors N is much larger than the number of training vectors. As a classifier we use a linear homogeneous function

f
:

ℝ
N

→

ℝ
1

. It is assumed that for each object with the number i there is a cluster set

K
^

I

⊂

ℝ
N

consisting of Ki
training vectors corresponding to the observations of this object, for example, a set of its digitized photographs. In the case when

N
≫
K
=

K
1

+
⋯
+

K
n

a linear homogeneous classifier, as a rule, exists. We describe the algorithm for constructing the classifier and discuss the properties of this algorithm.
3D modelling of angular spindle’s head for machining centre
Authors: Krol O , Sokolov V 
Published: August 2019

Abstract
The unified design of the angular spindle head of the machining centre for drilling-milling and boring type is considered. Three-dimensional modeling of the angular head assembly in CAD KOMPAS-3D is performed using a specialized application “Shafts and 3D mechanical transmissions” including a three-dimensional representation of the machining centre kinematic scheme. The photorealistic visualization module Artisan Rendering, which is integrated into the KOMPAS-3D CAD contour, was used to create presentations and promote this construction to the machine tool industry. A two-stage procedure for analyzing the structure by the stiffness criterion is proposed: at the early stages of the design by the matrix initial parameters method; at the stage of the working project by the finite element method in the APM FEM module. The procedure for determining the stress-strain state of the angular head spindle with end mills realized.
Nonlinear simulation of electrohydraulic drive for technological equipment
Authors: Sokolov V , Krol O , Stepanova O 
Published: August 2019

Abstract
The problem of nonlinear simulation of the dynamic characteristics of the electrohydraulic servo drives with throttle regulation for technological equipment is considered. The mathematical model for investigation of the nonstationary work processes in the drives has developed. The model adapted for drives of the technological equipment, built using standard modules, in particular, an electrohydraulic amplifier and a hydraulic cylinder. The estimation of the basic parameters of the mathematical model is carried out using the technical certificate data of the drive devices. The recommendations are given on setting initial data for numerical simulation. For numerical integration of the nonlinear mathematical model of the nonstationary work processes software was developed in the environment of the MATLAB. In addition to the integration subroutine, the software includes a source data file, a control program and a subroutine for calculating the right parts of the system of ordinary differential equations. The example of the calculation of the dynamic characteristics for the electrohydraulic servo drive with throttle regulation is presented.
Application of computer simulation models in the study of the impact of data buffering on the quality of control in network systems
Authors: Abramov G V , Avcinov I A , Emelyanov A E , Sukhanova N V 
Published: August 2019

Abstract
The work focuses on the computer simulation modeling of the control system with the network channel of information transmission. We have studied the impact of data buffering on the quality of control for the systems with a limited volume buffer for data packets. It has been expected that the data packet transmission over the network channel for the quantization period is carried out with a given probability. If the data packet from the digital sensor is not transmitted in one quantization tact to the controller, it is placed in the sensor buffer. During data is transmitted over the channel, all packets from the sensor buffer are transmitted to the controller buffer. The controller processes incoming data from the buffer sequentially-one packet per quantization tact. To simulate such situations, it was proposed to use the appropriate developed random processes. The novelty of the developed simulation model lies in the fact that in the basis for the development of this model is accepted the modeling of the time gap of the information flow of data. Simulation of the network control system operation was carried out in the environment Simulink of Matlab system.
Numerical study of cyclic adsorption processes of air oxygen enrichment in dynamics
Authors: Akulinin E I , Golubyatnikov O O , Dvoretsky D S , Dvoretsky S I 
Published: August 2019

AbstractThe paper discusses the results of numerical analysis of the properties and modes of the adsorption air separation process and oxygen concentration with purity of ∼90% carried out in a double-adsorber PSA unit with a 13X granular zeolite adsorbent with capacity of up to 2 l/min. Calculation experiments have been performed using the developed mathematical model and the influence of perturbations (temperature, composition and pressure of atmospheric air) on the dynamics of the process, the unit performance, the extraction degree and oxygen purity has been investigated. It has been established that the most effective control action is the pressure at the compressor outlet, the increase in which from 2 to 6×105Pa leads to the increase in the extraction degree and oxygen concentration on average by ∼57% and ∼12 vol.% respectively.
Mathematical modeling of deformations of flexible threads under their dynamic loading in the zone of material plasticity
Authors: Tarasov D , Konovalov V , Zaitsev V , Rodionov Yu 
Published: August 2019

Abstract
The object of study is a vertical flexible thread rotating at some distance around a vertical axis with a lateral load. The calculation is made for the dynamic load condition in the form of centrifugal forces depending on the displacement of the thread from the initial position. The geometric and physical nonlinearity of the flexible threads is taken into account. The proposed method is based on the theory of mathematical modeling using differential and integral calculus of functions of one and several variables as well as on the theory of resistance of materials. A method of the nonlinear calculation of the stress-strain state of flexible threads, taking into account the real properties of materials is proposed. The text of the calculation in the computer program MatchCAD for calculations of the thread, its deformation and tension was theoretically described and developed. The calculation results corresponded to the results obtained by the finite element method (the discrepancy is about 1%). The implementation of the method makes it possible to study the operation of structures outside the conditions of elastic work of the material. The comparative results of modeling inertia loaded rotating threads with linear properties of changes in their strength properties and in the case of nonlinearity of their properties are presented.
Modeling of the droplet surface dried on a solid substrate
Authors: Pakhomov A , Gatapova N , Pakhomova Y 
Published: August 2019

Abstract
The paper presents an approach to modeling the surface of a liquid droplet lying on a solid substrate. Receiving the real shape of the droplet surface plays an important role in modeling the process of drying droplets of liquid dispersed systems on solid diffusion-impermeable substrates. This relates to the strong influence of the characteristics of the droplet surface on the values of the coefficients of heat and mass transfer and the value of the surface area of evaporation. A description of the experimental setup for determining the characteristic parameters of the droplet surface is presented. The formulation and solution to the problem of mathematical modeling of the shape of the droplet’s surface, depending on the wetting angle of the liquid-substrate system, surface tension and droplet parameters, are given. The incorrectness of the assumption about the shape of a droplet as an element of a sphere segment is shown. Some results of visualization of the surface of a droplet for various wettability conditions are presented.
Experimental plant for studying hydrodynamics and heat and mass exchange processes in packing contact devices
Authors: Merentsov N A , Persidskiy A V , Topilin M V , Lebedev V N , Balashov V A , Golovanchikov A B 
Published: August 2019

Abstract
The paper provides a description of the developed experimental plant for studying hydrodynamic and heat and mass exchange processes in packing devices of all kinds of configuration, examples of the obtained data and original classification methods for processing experimental data. The authors describe hydrodynamic characteristics allowing carrying out classification studies and obtaining the necessary data to complete the developed methods for calculating mass exchange devices: the retaining capacity of packing devices at liquid and gas phases in particular. The authors provide the criteria function X=f(Rem) which gives a direction for industrial application of packing contact devises. The function is based on the analysis and generalization of the experimental data obtained in express studies of single-phase filtration curves. The paper also covers an example of the experimental data of the response function in case of recognizing flow structures of contact phases which allow obtaining necessary data to complete the developed diffusion models of mass exchange processes and implement calculations of mass exchange packing with a high precision.
Simulation of the process of rectification with the account of longitudinal diffusion
Authors: Golovanchikov A B , Prokhorenko N A , Shibitova N V , Romanenko M D , Zalipayeva O A 
Published: August 2019

Abstract
Based on the differential equations of material balance and mass transfer, taking into account the longitudinal mixing of the boiling solution, the formulas of the working lines of the reinforcing and exhaustive parts of the packed distillation column, the concentration profiles along the nozzle height, and the algorithm for calculating the height of the nozzle are proposed.The equations of the working lines of the reinforcing and exhaustive parts of the distillation column are analytically derived, taking into account the longitudinal diffusion, which, when the longitudinal diffusion number or the longitudinal diffusion coefficient, is transformed into the known equations of the working lines for the flow patterns of ideal displacement in both phases. Analytically, on the basis of the differential equations of material balance, the equations of working lines and mass transfer in a rectifying column for binary mixtures with allowance for longitudinal diffusion are derived. It is shown that in its absence, when the flow structure for both phases corresponds to an ideal displacement, that is, the Peclet number of longitudinal diffusion, and the longitudinal diffusion coefficient itself, the resulting equations of working lines and mass transfer become known equations for the reinforcing and exhaustive parts of the column. Comparative examples of calculations for typical structures of the ideal displacement flow and for derived equations that take into account longitudinal diffusion for the binary mixture “ethyl alcohol-ethyl alcohol” are given.
Parametrization and manufacturing of a combined electrode tool using additive technologies and modern computer-aided design systems
Authors: Suvorov A 
Published: August 2019

Abstract
The research is aimed at modernizing the technology of designing and manufacturing an electrode instrument for electrical processing methods in order to reduce costs in terms of experimental design and individual production. In this regard, the article is aimed at disclosing the possibilities of using modern computer-aided design tools and rapid prototyping technology for the manufacture of a complex profile tool for individual and experimental production. The materials of the article are of practical value for enterprises of the machine-building complex, as they allow making changes in the technology of designing and manufacturing electrode tools for electrical processing methods and using modern computer-aided design systems and additive technologies that reduce the cost and increase the variability of its application.
Simulation images of external objects in a virtual simulator for training human-machine systems operators
Authors: Alekseev V , Lakomov D , Shishkin A , Al Maamari G , Nasraoui M 
Published: August 2019

Abstract
The article presents the results of a study of the contour analysis algorithm developed by the authors for automatic recognition of objects in an image with their subsequent modeling in virtual simulators for training human-computer systems operators. The main distinctive feature of the developed contour analysis algorithm is the use of image convolution in four directions and the tracing procedure, which makes it possible to more accurately search for the contour of objects compared to other algorithms of this type. The results of the study of the algorithm are given. Based on this study, recommendations on the choice of the parameters of the algorithm are given. As a result of the analysis of three-dimensional modeling methods, it was concluded that for the effective implementation of three-dimensional graphics in virtual simulators for training human-machine system operators, it is advisable to use an algorithm for contour image analysis of external objects.
Algorithm for the boundary detection of dental crowns for 3D dental model segmentation
Authors: Pupykina A A , Ochepovsky A V , Gushchina O M , Nasonov D A 
Published: August 2019

Abstract
This paper presents the segmentation algorithm on the 3D digital dental model for separating individual dental crown using fuzzy multi criteria analysis and Visualization Toolkit (VTK). The aim is to apply the algorithm in the 3D aligner development software package. The digital dental model is produced by 3D scanner in STL format and dental crown contour is calculated based two control points defined by user. Fussy multi criteria analysis with pairwise comparison of the mesh points aims to select a points subset that define the boundary between the dental crown and the jawbone. VTK provides ease of use computer graphics algorithms and visualisation tools. The result has shown that the proposed approach can successfully separate dental crown on the 3D digital dental model.
Ar-powered educational application based upon convolutional neural network
Authors: Gushchina O M , Ochepovsky A V , Rogova N N , Pupykina A A 
Published: August 2019

Abstract
This research aims to justify the importance of using convolutional neural networks (CNN) in AR-powered educational applications to provide the learning process with impressive visualization of studied objects. Demonstration of the developed application proves neural network to be its basic part that allows for high-quality accuracy of object localization and image recognition in AR systems. As these systems provide a more informative and impressive way of learning, the application can be used for data mining and big data analysis disciplines to demonstrate real-time operation of localization, clustering and segmentation algorithms.
The calculation of the impedance of biological tissue on the model of Yamamoto in the process of galvanic effects
Authors: Gorbunov A , Gromov Y , Egorov V 
Published: August 2019

Abstract
The purpose of this work is to improve the accuracy of research related to the work in the field of modeling and measurement of galvanic processes in biological tissues under the influence of electric current. For this purpose, we propose a refined equivalent electrical model of biotissue and an algorithm for numerical determination of its components.
An Evaluation Graph of Hourly Rainfall Estimation in Malang
Authors: Putra R M , Kurniawan A , Rangga I A , Ryan M , Endarwin  , Luthfi A 
Published: August 2019

Abstract
Satellite-based rainfall estimation is evolving rapidly. Most studies use data, which is spatially fine, but poorly regarding time. On the other hand, availability of verification data is also quite rare. This study used Hillman Form B report that was corrected by ME-48 from Malang Climatological Station. 2009-2016 IR1 satellite data were used in hourly temporal resolution (only less than 3% data missing). Four estimation methods were compared: Auto Estimator, CST, mCST, and Quantile Analysis Equation. Data processing was carried out using Python and R statistic as a quality control. The analysis was done by creating a graph that combines False Alarm and Miss Information for each rainfall intensity. Binary transformation was done for enabling information to be plotted. All rainfall estimation methods have a high false alarm (more than 74% at 1 mm) but quite low miss (less than 0.03%). By taking into account its error pattern, satellite data can be used in rainfall observation. The Quantile equation is slightly superior to other methods. This study is relatively inexpensive to be duplicated so it can be used as an evaluation tool for rainfall estimation best practice for Meteorological and Climatological Agency’s network.
Chemical Composition of Fine Particulate Matter from Peat Forest Fires at Palangka Raya and Its Dispersion using HYSPLIT
Authors: Lestiani D D , Santoso M , Kurniawati S , Sari D K , Kusmartini I , Manurung A , Riadi A 
Published: August 2019

Abstract
An air quality monitoring was conducted to investigate the chemical characteristics of particulate emissions in peat forest fires at Palangka Raya, Indonesia during 2012 where a peat forest fire episode occurred. Aerosol samples were collected at Palangka Raya where represents a sub urban site downwind of the peat forest fires. The samples were collected using Gent stacked filter unit sampler. The sampler provides two size fractions: coarse (2.5-10 μm equivalent aerodynamic diameters EAD) and fine (<2.5 μm EAD). Black carbon (BC) was measured using Smoke Stain Reflectometer, and elemental compositions were analyzed using X-ray Fluorescence (XRF). The concentrations of PM2.5 during a haze episode were significantly different about seven to eight times higher when compared to the concentrations in non-haze conditions. The major components of PM2.5 in peat smoke haze consist of sulphur, biomass burning component (BC, K), and crustal components (Al, Fe, Si). The sulphur mainly comes from the peat as it is the earliest stage of transition from compressed plant growth to the formation of coal. The dispersion pattern to show the effect of wind direction using the Hybrid Single Particle Lagrangian Integrated Trajectory Model (HYSPLIT) simulation was also applied.
Unveiling of the SST gradient over the South China Sea and its possible relationship to the Asian precipitation
Authors: Vaid B H 
Published: August 2019

Abstract
The present study examines the Sea Surface Temperature (SST) variations over the South China Sea (SCS) using the National Oceanic and Atmospheric Administration (NOAA) SST daily datasets for the period 1988–2009. In the SST over the South China Sea (SCS), a north-west versus south-east SST gradient (hereafter gra-SCS SST) is revealed. This SST gradient is seen to be induced by the distinct wind anomaly along with fresh water flux changes. The slope difference between the gra-SCS SST before and after 1999 is observed to be statistically significantly different than zero at a 95% confidence level. A decreasing/increasing trend in the gra-SCS SST is revealed before/after 1999. Besides, it is found that the gra-SCS SST characterizes the Asian monsoon variability by inducing cross equatorial monsoon flow towards the Asian Continent. In addition, we established the role of the gra-SCS SST in the Asian monsoon by computing causation based on the information flow concept between the gra-SCS SST and traditional monsoon indices, which pronounces that former impact the later. Based on the present corollary, we suggest that the gra-SCS SST should be considered as an important parameter in the climate studies as it is meticulously related to the precipitation over Asia.