bluuebunny/crossref_metadata_2025_split huggingface dataset:
Systematic large-scale meta-analysis identifies miRNA-429/200a/b and miRNA-141/200c clusters as biomarkers for necrotizing enterocolitis in newborn
Authors: Liu Hong , Wang Yi-Biao 
Published: August 2019

Abstract
Necrotizing enterocolitis (NEC) is a critical neonatal disease with a high mortality. The possibility that miRNAs may play an important role in NEC has raised great attention. Hence, the present study identified biomarkers that affected NEC in newborn progression through miRNA and gene expression profile analysis. miRNA chip GSE68054 and gene chip GSE46619 of NEC in newborn were analyzed to screen out differentially expressed miRNA and differentially expressed genes (DEGs). Next, target genes of differentially expressed miRNA were predicted, and differentially expressed miRNA-DEG regulatory network was constructed to select key miRNAs. After gene ontology and kyoto encyclopedia of genes and genomes enrichment analysis on target genes of key miRNAs, the target genes enriched in pathways were extracted to establish differentially expressed miRNA-DEG-disease gene network for gene interaction analysis. Targetting relationship between miRNAs and target genes was verified. A total of 15 miRNAs were differentially expressed in NEC in newborn, amongst which miR-429/200a/b and miR-141/200c clusters were poorly expressed and might play a significant role in NEC in newborn. Besides, target genes of miR-429/200a/b and miR-141/200c clusters were enriched in 11 signaling pathways. Vascular endothelial growth factor (VEGFA), E-selectin (SELE), kinase insert domain receptor (KDR), fms-related tyrosine kinase 1 (FLT1), and hepatocyte growth factor (HGF) were highly expressed in NEC in newborn, which were negatively regulated by miR-429/200a/b and miR-141/200c clusters and shared close association with disease genes. miR-429/200a/b and miR-141/200c clusters are poorly expressed while their target genes (VEGFA, SELE, KDR, FLT1, and HGF) are highly expressed in NEC in newborn, which might be identified as important biomarkers for this disease.
Tips and Tricks in Contrast-Enhanced Ultrasound (CEUS) for the Characterization and Detection of Liver Malignancies
Authors: Schellhaas Barbara , Strobel Deike 
Published: August 2019

AbstractContrast-enhanced ultrasound (CEUS) has a high diagnostic accuracy in the assessment of focal liver lesions. Clinical context (presence of liver cirrhosis, history of other malignancy versus incidental finding) is crucial for the correct interpretation of CEUS findings. CEUS has to be preceded by structured anamnesis and clinical examination as well as accurate B-mode sonography. Metastases are the most common malignant liver lesions in a non-cirrhotic liver. According to their contrast enhancement in the arterial phase, metastases are categorized as hyper- and hypo-vascular metastases. A common feature of all metastatic lesions is washout of the contrast agent in the portal venous or late phase. In the context of liver cirrhosis, > 95 % of focal liver lesions are hepatocellular carcinomas (HCCs). HCCs typically show arterial phase hyperenhancement, followed by mild and gradual contrast washout occurring very late in the late phase. For intrahepatic cholangiocellular carcinoma (ICC), the pattern of contrast enhancement in the arterial phase can vary. However, all ICCs typically show early and pronounced washout. Other liver malignancies like lymphoma, angiosarcoma, epithelioid hemangioendothelioma and others are very rare. Except for the contrast washout seen in all liver malignancies, they do not display pathognomonic enhancement patterns upon CEUS. Thus, biopsy is indispensable for definite diagnosis of the tumor entity. Furthermore, CEUS is used for the detection of metastases and therapeutic monitoring after local ablative procedures. The examination procedure differs slightly depending on the specific indication (characterization, detection).
Long-term follow-up after multiple plastic stenting for refractory pancreatic duct strictures in chronic pancreatitis
Authors: Tringali Andrea , Bove Vincenzo , Vadalà di Prampero Salvatore F. , Boškoski Ivo , Familiari Pietro , Perri Vincenzo , Costamagna Guido 
Published: August 2019

Abstract
Background Dominant pancreatic duct strictures in chronic pancreatitis are often managed by endoscopic placement of a single plastic stent. Insertion of multiple plastic stents (MPS) has been proven to be effective in managing refractory strictures, but data are still limited. The aim of this study was to investigate the efficacy and long-term results of MPS to dilate pancreatic duct strictures in chronic pancreatitis.
Methods 48 patients (34 men; mean age 44 years) with chronic pancreatitis and a single pancreatic stent through a refractory stricture in the pancreatic head underwent the following protocol: 1) removal of the single pancreatic stent; 2) balloon dilation of the stricture; 3) insertion of the maximum number of stents; 4) stent removal after 6 – 12 months.
Results The median number of pancreatic plastic stents placed was 3 (diameter 7 – 11.5 Fr, length 3 – 7 cm). Five patients (10.4 %) had persistent strictures after MPS removal. During a mean follow-up of 9.5 years (0.3 – 15.5 years) after stent removal, 74.4 % (32/43) of the patients were asymptomatic, and 25.6 % (11/43) experienced pancreatitis recurrence or pancreatic type pain after a mean time of 26.4 months (8/43, 18.6 % underwent plug extraction without evidence of stricture recurrence; 3/43, 7.0 % had stricture recurrence). No major complications were recorded.
Conclusion Endoscopic multiple plastic stenting of chronic pancreatitis-related pancreatic duct strictures showed satisfactory long-term results, with the option of re-treatment. This procedure can be considered an important therapeutic alternative for painful pancreatic duct strictures located in the head of the pancreas in the setting of chronic pancreatitis.
Vitalstoffmangel trotz Nahrungsüberfluss
Authors: Schmidt Edmund , Schmidt Nathalie 
Published: August 2019

ZusammenfassungVitalstoffmangel trotz Nahrungsüberfluss – das heutige Nahrungsangebot ist vielfältig wie nie. Trotzdem treten Vitalstoffmängel auf, mit gesundheitlichen Folgen. Gründe dafür sind u. a. die Verarbeitung und Zubereitung der Nahrungsmittel, Umwelteinflüsse, Vitalstoffverluste durch lange Transportwege und Lagerung, qualitative Unterschiede in der Tierhaltung und nicht zuletzt Ernährungsgewohnheiten und Lebensstil.Anhand wichtiger Vitalstoffe wird die Bedeutung einer ausreichenden Versorgung evident. Die Begleitung durch einen Therapeuten bei Vitalstoffmängeln ist ratsam, um bestmögliche Therapieerfolge zu erzielen und Überdosierungen, wie sie bei der Selbstbehandlung nicht selten vorkommen, zu vermeiden.
Clip-assisted endoscopic cyanoacrylate injection for gastric varices with a gastrorenal shunt: a multicenter study
Authors: Zhang Mingyan , Li Ping , Mou Haijun , Shi Yongjun , Tuo Biguang , Jin Suyun , Sun Ruonan , Wang Guangchuan , Ma Jiali , Zhang Chunqing 
Published: August 2019

Abstract
Background The aim of this study was to evaluate the safety and efficacy of clip-assisted endoscopic cyanoacrylate injection for gastric varices with a gastrorenal shunt.
Methods Records were reviewed of patients with gastric varices and concomitant gastrorenal shunts who underwent clip-assisted endoscopic cyanoacrylate injection at three tertiary centers between April 2016 and October 2018. The assessed outcomes were technical success rate, eradication of gastric varices, cyanoacrylate embolization, and all-cause rebleeding.
Results A total of 61 patients were analyzed. The procedure was successful in all patients (100 %). Gastric varices were eradicated in 30 of 33 patients (90.9 %) according to contrast-enhanced computed tomography re-examination within 1 month after the procedure. No symptoms or signs of cyanoacrylate embolization related to the procedure were observed. Four patients (6.6 %) were lost to follow-up. All-cause rebleeding occurred in 13/57 patients (22.8 %) during a median follow-up period of 225 days (interquartile range 114 – 507 days).
Conclusions Clip-assisted endoscopic cyanoacrylate injection appeared to be a safe procedure that was convenient and efficacious in the treatment of gastric varices with concomitant gastrorenal shunt.
Lysophosphatidylcholine is a Major Component of Platelet Microvesicles Promoting Platelet Activation and Reporting Atherosclerotic Plaque Instability
Authors: Diehl Philipp , Nienaber Frederik , Zaldivia Maria T. K. , Stamm Johannes , Siegel Patrick M. , Mellett Natalie A. , Wessinger Marius , Wang Xiaowei , McFadyen James D. , Bassler Nicole , Puetz Gerhard , Htun Nay M. , Braig David , Habersberger Jonathon , Helbing Thomas , Eisenhardt Steffen U. , Fuller Maria , Bode Christoph , Meikle Peter J. , Chen Yung Chih , Peter Karlheinz 
Published: August 2019

Background Microvesicles (MVs) are small cell-derived vesicles, which are mainly released by activated cells. They are part of a communication network delivering biomolecules, for example, inflammatory molecules, via the blood circulation to remote cells in the body. Platelet-derived MVs are known to induce vascular inflammation. Research on the mediators and mechanisms of their inflammatory effects has attracted major interest. We hypothesize that specific lipids are the mediators of vascular inflammation caused by platelet-derived MVs.
Methods and Results Liquid chromatography electrospray ionization–tandem mass spectrometry was used for lipid profiling of platelet-derived MVs. Lysophosphatidylcholine (LPC) was found to be a major component of platelet-derived MVs. Investigating the direct effects of LPC, we found that it induces platelet activation, spreading, migration and aggregation as well as formation of inflammatory platelet–monocyte aggregates. We show for the first time that platelets express the LPC receptor G2AR, which mediates LPC-induced platelet activation. In a mouse model of atherosclerotic plaque instability/rupture, circulating LPC was detected as a surrogate marker of plaque instability. These findings were confirmed by matrix-assisted laser desorption ionization imaging, which showed that the LPC concentration of human plaques was highest in vulnerable plaque regions.
Conclusion LPC is a major component of platelet-derived MVs and via its interaction with G2AR on platelets contributes to platelet activation, spreading, migration and aggregation and ultimately to vascular inflammation. Circulating LPC reports on atherosclerotic plaque instability in mice and is significantly increased in unstable areas of atherosclerotic plaques in both mice and humans, linking LPC to plaque instability.
Diagnostic Testing in Central Nervous System Infection
Authors: Kanjilal Sanjat , Cho Tracey A. , Piantadosi Anne 
Published: August 2019

AbstractPatients with central nervous system (CNS) infection experience very high levels of morbidity and mortality, in part because of the many challenges inherent to the diagnosis of CNS infection and identification of a causative pathogen. The clinical presentation of CNS infection is nonspecific, so clinicians must often order and interpret many diagnostic tests in parallel. This can be a daunting task given the large number of potential pathogens and the availability of different testing modalities. Here, we review traditional diagnostic techniques including Gram stain and culture, serology, and polymerase chain reaction (PCR). We highlight which of these are recommended for the pathogens most commonly tested among U.S. patients with suspected CNS infection. Finally, we describe the newer broad-range diagnostic approaches, multiplex PCR and metagenomic sequencing, which are increasingly used in clinical practice.
Gross Anatomy of the Heart of Pampas Deer (Ozotoceros bezoarticus, Linnaeus 1758)
Authors: Vazquez Noelia , Dos Santos Dellis , Pérez William , Artigas Rody , Sorriba Victoria 
Published: August 2019

AbstractThe pampas deer belongs to the Cervidae family (Artiodactyla order). It used to be a common and abundant species that had a wide distribution. However, at the end of the 19th century, the populations were decimated. In general, the hearts of mammals share many similarities, but size, shape, position, vessel organization and branching can vary among species. The objective of the present study was to describe the macroscopic morphology, topography and irrigation of the heart of the pampas deer. The anatomical study was conducted with 20 animals that had died of natural causes. The animals were studied by simple dissection. All animals had colored latex injected into one of the common carotid arteries to facilitate the visualization. The position of the heart, with a 45° axis, the presence of a double sternopericardial ligament, and the bilateral cardiac circulation were some of the notable findings.
Imaging of Intracranial Infections
Authors: Abdalkader Mohamad , Xie Juliana , Cervantes-Arslanian Anna , Takahashi Courtney , Mian Asim Z. 
Published: August 2019

Central nervous system (CNS) infections are a major source of morbidity and mortality despite the remarkable progress in prevention and treatment of infectious disease. Because of the difficulty of direct tissue sampling, imaging plays a crucial role in detecting, diagnosing, and monitoring the therapeutic response of CNS infections. An accurate diagnosis in CNS infections is especially rewarding, given the availability of potential effective antimicrobials.Bacterial, viral, fungal, and parasitic infections may affect the brain and/or its meningeal coverings, and can be characterized by a variety of radiological patterns that help narrow the differential diagnoses and eventually tailor the optimal management.This review addresses the typical imaging findings of intracranial infectious diseases in both immunocompetent and immunocompromised patients.
Platelet-Rich Plasma: Principles and Applications in Plastic Surgery
Authors: Abu-Ghname Amjed , Perdanasari Aurelia Trisliana , Davis Matthew J. , Reece Edward M. 
Published: August 2019

AbstractPlatelet-rich plasma (PRP) is an autogenously harvested liquid platelet concentrate extracted from a patient's peripheral blood that contains higher than baseline concentrations of growth factors and cytokines. This innovative new technology has demonstrated great promise in the field of plastic surgery, and its use has been evaluated in several clinical settings including wound healing, hair restoration, and skin rejuvenation. The goal of this article is to explain the biology behind PRP and to review the basic principles involved in its preparation. This will be followed by a discussion of some clinical applications of PRP in both aesthetic and reconstructive plastic surgery.
Principles and Applications of Fat Grafting in Plastic Surgery
Authors: Abu-Ghname Amjed , Perdanasari Aurelia Trisliana , Reece Edward M. 
Published: August 2019

AbstractAutologous fat transplantation has become increasingly popular in recent years. Its biocompatable properties and availability made it a widely used treatment modality for soft tissue augmentation and volume replacement in both reconstructive and aesthetic plastic surgery. Multiple protocols and clinical applications have been described in the literature, with wide variations in the harvesting, processing, and injection techniques. In this review, the authors will discuss the basic principles and clinical applications of fat grafting in plastic and reconstructive surgery. The article will then conclude with a discussion of fat grafting limitations as well as potential future applications, giving the reader a well-rounded understanding of autologous fat transfer.
Cancer-Associated Thrombosis: A Two-Way Street
Authors: Sharma Bal Krishan , Flick Matthew J. , Palumbo Joseph S. 
Published: August 2019

AbstractPathological activation of the coagulation system occurs with virtually all forms of cancer, particularly epithelial malignancies. Accordingly, thrombosis is one of the most common comorbidities associated with cancer. Indeed, cancer-associated thromboembolism is the second leading cause of death for cancer patients, second only to the cancer itself. The identification of specific molecular mechanisms whereby tumor cells activate the coagulation system and drive thrombosis has been an active area of investigation for several decades. Studies in animal models and human trials have revealed that there is a bidirectional relationship between coagulation factor activity and cancer, whereby the pathological hemostatic system activation associated with cancer not only promotes thromboembolism but also drives progression of the malignancy. Numerous studies indicate that factors up and down the clotting cascade can contribute to various stages of cancer, including tumorigenesis, primary tumor growth, and metastasis. Although there are some mechanistic points of commonality, there are also clearly context-dependent contributions of coagulation components to cancer progression dependent on the type of cancer and stage of disease. It is also notable that in some instances, coagulation factors appear to contribute to cancer progression independently of their traditional roles in hemostasis and thrombosis. Here, the authors review the current state of the field with regard to hemostatic factor-driven cancer pathogenesis.
Level of Physical Activity on the Body Image of Young Women
Authors: Santana Katielly , Ferraz Almir de França , Dias André Rodrigues Lourenço , Rodrigues Rosilene Andrade Silva , Pasa Camila , Fett Waléria Christiane Rezende , Viana Michell Vetoracci , Figueira Aylton , Fett Carlos Alexandre 
Published: August 2019

AbstractPhysical exercise has the ability to alter the measurements of the body related to esthetic. The objective of the present study was to compare the body image and body esthetic between two groups of women with different levels of physical activity. We evaluated 79 women who were divided into 2 groups: 39 women with low or moderate levels of physical activity, and 40 women with high levels of physical activity according to the International Physical Activity Questionnaire (IPAQ). Anthropometric and body composition measurements were taken using the InBody S10 multifrequency device (InBody Co., Eonju-ro, Gangnam-gu, Seoul, South Korea). The scale of silhouettes, which is composed of 9 engravings of body images, was used to verify the body image, as well as the Portuguese version of the Body Shape Questionnaire (BSQ) validated for university students. The group of evaluators was composed of twenty physical education professionals of both sexes, ten male and ten female. The group with low/moderate levels of physical activity, as expected, showed a lower amount (minutes per week) of physical activity of mild, moderate and vigorous intensity when compared with the group with high levels of physical activity (p < 0.05), and they also had a higher ratio of fat mass (FM) per height squared (p = 0.047). The BSQ questionnaire scores, the current and ideal silhouettes, as well as body image dissatisfaction, were not different between the groups (p > 0.05). The overall body esthetic score, attributed only by the male and only by the female evaluators, did not differ significantly (p > 0.05). We concluded that the level of physical activity did not influence the body image and body esthetic of the women.
Constructing a corpus-informed list of Arabic formulaic sequences (ArFSs) for language pedagogy and technology
Authors: Alghamdi Ayman , Atwell Eric 
Published: August 2019

AbstractThis study aims to construct a corpus-informed list of Arabic Formulaic Sequences (ArFSs) for use in language pedagogy (LP) and Natural Language Processing (NLP) applications. A hybrid mixed methods model was adopted for extracting ArFSs from a corpus, that combined automatic and manual extracting methods, based on well-established quantitative and qualitative criteria that are relevant from the perspective of LP and NLP. The pedagogical implications of this list are examined to facilitate the inclusion of ArFSs in the process of learning and teaching Arabic, particularly for non-native speakers. The computational implications of the ArFSs list are related to the key role of the ArFSs as a novel language resource in the improvement of various Arabic NLP tasks.
Density of Clouded Leopard (Neofelis nebulosa) in Gunung Basor-Stong Utara Forest Reserve, Kelantan, Malaysia
Authors: Hamirul Shah Ab Razak Muhamad , Hambali Kamarul , Anis Amaludin Nazahatul , Eh Rak Aweng , Hanisah Abdul Malek Nur 
Published: August 2019

Abstract
To date, much of the information on the clouded leopard study were more focus on Sunda clouded leopard. With the advance of technology, the use of camera trap had enhanced the opportunity for all researchers to study more deeply on species of interest in more intensely larger scale and cost benefit. This paper presents the density estimate of clouded leopard in Gunung Basor-Stong Utara Forest Complex (GB-SUFC). A total of 19 individuals of clouded leopard (14 males, 5 unknown) had been identified. Based on the spatial explicit capture-recapture model (SECR). The estimate density of the clouded leopard in GB-SUFC was (D^±SE) 1.15±0.35 adult clouded leopard/100km2. Results from this study will serve as an important baseline on the population density of clouded leopard in GB-SUFC and provides more information on clouded leopard population and ecology especially in Peninsular Malaysia and could also potentially guide and assist the authorities in formulating crucial conservation plans for this threatened species.
Annotated checklist of odonates (Insecta: Odonata) in Sungai Bantang Recreational Forest, Bekok, Johor, Malaysia
Authors: Abdul Aziz M A A , Mohamed M 
Published: August 2019

Abstract
A total of 34 species of odonates, including 17 species of dragonflies (Anisoptera) belonging to 2 families, and 15 species of damselflies (Zygoptera) belonging to 8 families were collected and recorded from Hutan Lipur Sungai Bantang in January, May and July 2017. From the suborder Anisoptera, Libellulidae is the most dominant family with 15 species and from the suborder Zygoptera, the richest family were Chlorocyphidae, Euphaeidae and Platycnemididae, each with three species respectively. A detailed list of odonates recorded from Hutan Lipur Sungai Bantang is presented. The result forms a baseline data of odonate fauna in this forest reserve useful in the monitoring of water quality of rivers found in the forest reserves in the future.
Optimization of Sunnah Food-Based Cookies Formulation
Authors: Hakimi Abdul Khairi Amir , Kormin Faridah , Alyani Zainol Abidin Nurul , Aini Fatihah Anuar Nur , Shafawati Mohd Shafiie Nor 
Published: August 2019

Abstract
Iron deficiency may occur to any individual but it was a major concern for pregnant woman. Loss of blood during maternal bleeding may lead to iron deficiency and this situation shoud be avoided for pregnant woman. Sunnah cookies is rich in iron and other minerals which help to boost iron content in the body. The aim of this study was to optimize the formulation of cookies enrich with Sunnah food such as raisins, dates, honey and figs. The value-added cookie samples were prepared in twenty-four formulations and the combination was through the application of Simplex-centroid mixture design by Design Expert. Mineral and proximate value were determined by using Atomic Absorption Spectrophotometer while sensory evaluation was measured in terms of nine dependent variables by 60 untrained panelists using 9-point hedonic scale. Results showed that the combination of 64% of honey and 36% of figs gave the highest desirability value of 0.692. The value of iron, magnesium and zinc were 9.04, 164.58 and 27.38 mg/kg respectively. However, sensory evaluation revealed that sample cookies number 753 (the highest quality score of acceptability in terms of taste, texture, odor, sweetness, sourness and overall acceptability.