bluuebunny/crossref_metadata_2025_split huggingface dataset:
Abnormal cranium development in children and adolescents affected by syndromes or diseases associated with neurodysfunction: a retrospective analysis
Authors: Guzik Agnieszka , Perenc Lidia , Drużbicki Mariusz , Podgórska-Bednarz Justyna 
Published: August 2019

Abstract
Background: Microcephaly and macrocephaly are cranial growth defects and at the same time clinical symptoms. There are two assessment criteria, one applied in dysmorphology and the other conventionally used in clinical practice. Which one should be used on a daily basis and what is the relationship between microcephaly or macrocephaly and the syndromes or diseases associated with neurodysfunction?. The study was designed to investigate the associations between abnormal cranium development (head size) and diseases or syndromes linked with neurodysfunction, based on essential data collected upon admission of the patients to the Neurological Rehabilitation Ward for Children and Adolescents. Methods: Retrospective analysis took into account 327 children and adolescents with medical conditions associated with neurodysfunction. In order to identify the subgroups of subjects with microcephaly, normal head size, and macrocephaly two assessment criteria were applied, one system commonly used in clinical practice and the other – applied in dysmorphology. To enable assessment based on all the above criteria, z-score for head circumference (z-score hc) was computed for each study participant. Normative values published earlier were used as reference.Results: The subjects were divided into seven subgroups – six with diseases/syndromes usually associated with encephalopathy (90.2%), and one with diseases commonly occurring without encephalopathy, i.e. neuromuscular disorders (9.8%). The findings showed more/less common co-occurrence of as well as statistically significant relationships between: the size of the head - dysmorphology classification (hc), and diseases or syndromes associated with neurodysfunction (p=0.026), classification with regard to etiopathogenesis, presence and character of encephalopathy (p=0.010), epilepsy (p<0.001), hypothyroidism p=0.024, Cp=0.105); and the size of the head - traditional classification (hc) and entities or syndromes associated with neurodysfunction (p<0.001), classification with regard to etiopathogenesis, presence and character of encephalopathy (p<0.001), encephalopathy in neural tube defects (p=0.004, Cp=0.564), type of spasticity (p=0.034, Cp=0.211), epilepsy (p<0.001), as well as hypothyroidism (p<0.001).Conclusions: Children and adolescents with syndromes or diseases associated with neurodysfunction present abnormal cranium development (head size) and are found with microcephaly co-occurring with epilepsy and hypothyroidism. It was shown that the traditional classification enabled identification of a greater number of relationships, therefore it should be used in the daily practice.
Interventional effect of off-label use of alprostadil lipid microsphere injection in neurosurgical patients: a before-after study
Authors: luo hongli , Fan Qingze , Zhang Lunhui , Zhong Meng , Dong Limei 
Published: August 2019

Abstract
Background

As adjuvant drug, alprostadil lipid microsphere injection (Lipo-PGE1) is one of the highest-selling classes of drugs in China in recent years and the off-label use of Lipo-PGE1 is very common. To investigate the situation of the use of alprostadil lipid microsphere injection (Lipo-PGE1) and evaluate the clinical and economic impacts of administrative intervention in reducing inappropriate use of Lipo-PGE1 in neurosurgical patients in a Chinese tertiary hospital. Methods: A self-control study before and after an intervention of patients receiving Lipo-PGE1 was performed in the Department of Neurosurgery of the Affiliated Hospital of Southwest Medical University. Administrative interventions were implemented from January to December 2018, including reducing the volume of procurement of Lipo-PGE1, judging the rationality of medical records, establishing reward and punishment mechanism. The effects of administrative interventions on utilization and expenditure of Lipo-PGE1 were analyzed. Then patients admitted from January to December 2017 and from January to December 2018 were randomized extracted and then served as the pre-intervention and the post-intervention group for appropriateness analysis. Results: Administrative interventions significantly decreased prescribing rate (49.98% vs 22.49%), utilization (22311DDDs vs 8334 DDDs), drug use density (43.52 DDDs/TID vs 15.84 DDDs/TID), total cost (3.58 million CNY vs 1.30 million CNY) and average cost (2025.04 CNY vs 1466.49 CNY) of Lipo-PGE1 for all patients in neurosurgery. After administrative interventions, the rate in the use of no indications for Lipo-PGE1 and in the cases of inappropriate drug dose, frequency, menstruum type, combination and contraindications significantly decreased in cases collected (P < 0.05 or P < 0.001), yet the percentage of cases adhering to all the criteria was zero. Moreover, significant reductions were found in the average usage quantity (P=0.008), mean cost (P<0.001) and mean duration (P < 0.001) of Lipo-PGE1. Conclusion: As adjuvant drug, the off-label use of Lipo-PGE1 is very common in neurosurgery. The results from simple administrative intervention are unsatisfied. Combination of administrative intervention and clinical pharmacist real-time intervention should be introduced.
Challenges and factors associated with poor glycemic control among type 2 diabetes mellitus patients at Nekemte referral hospital, western Ethiopia: cross-sectional study
Authors: Fekadu Ginenus , Bula Kejela , Bayisa Getu 
Published: August 2019

Abstract
Background: Diabetes is increasing at an alarming rate throughout the world and about 80% of diabetics’ lives in developing countries. Similar to the rest of sub Saharan African countries, Ethiopia is experiencing significant burden of diabetes with increased prevalence, complications and mortality as well as life threatening disabilities. Reasons for poor glycemic control in type 2 diabetes are complex and multivariable. Hence, this study was aimed to identify challenges and factors associated with poor glycemic control among type 2 diabetes patients.
Method: A hospital based cross sectional study was conducted on type 2 diabetic patients attending diabetic clinic of Nekemte Referral Hospital (NRH) from February 1 to April 30, 2018. Fasting blood glucose of last three clinic visits were obtained and the mean fasting blood glucose measurements was used to determine the level of glycemic control. Analysis included both descriptive and inferential statistics with SPSS version 20.0. Predictor variable with P< 0.05 was considered statistically significant.
Result: Out of the total 228 included type 2 diabetes mellitus (DM) patients, 51.8% were males. The mean age of participants was 43±12.4 years and 154(67.5%) were found not following their general dietary program correctly. Nearly one third, 73(32%) of participants never attended diabetic education and 52(22.8%) of the patients had greater than 10 years’ duration on treatment. The majority, 148(64.9%) of patients had poor blood glucose control. Age range of 40-60 years (AOR=2.01, 95% CI 0.04-0.06, P=0.044), being illiterate (AOR = 3.12, 95 % CI 1.52-8.50, P=0.001), having informal education only (AOR=2.28, 95% CI 2.14-32.60, P=0.024), longer duration of diabetes treatment (>10 years) (AOR = 3.94, 95 % CI 1.51-27.83, P=0.012), inadequate physical exercise (AOR = 3.19, 95 % CI 1.05-19.84, P=0.019), smoking (AOR = 4.51, 95 % CI 0.00-0.50, p=0.022) were independent predictors of poor glycemic control up on a multivariable logistic regression analysis.
Conclusion: Nearly two third of patients had poorly controlled diabetes. Age, exercise, level of education, duration of the treatment and smoking were significantly associated with poor glycemic control. Health facilities should provide continuous education as well as barriers of glycemic control should be explored with further research.
DESEMPENHO AGRONÔMICO DE CULTIVARES DE ALFACE SOB ADUBAÇÃO ORGÂNICA EM SEROPÉDICA, RJ
Authors: Goulart Rafael Guthier Tavares , Dos Santos Carlos Antônio , De Oliveira Cristiana Maia , Costa Evandro Silva Pereira , De Oliveira Felipe Alves , Andrade Nairim Fidêncio de , Do Carmo Margarida Goréte Ferreira 
Published: August 2019

O objetivo do presente trabalho foi avaliar o efeito da aplicação de bokashi, esterco bovino, e da combinação entre estes, sobre o crescimento e produtividade de nove cultivares de alface (Lactuca sativa L.) nas condições de Seropédica-RJ. O ensaio foi realizado em condições de campo no período de setembro a outubro de 2017. Utilizaram-se como tratamentos quatro tipos de adubação, sendo: bokashi (0,5 kg/m2); mistura de bokashi com esterco bovino (0,250 kg/m2 +1,0 kg/m2, respectivamente); adubação com esterco bovino (2,0 kg/m2) e testemunha, em combinação com nove cultivares de alface (Babá de Verão, Elisa, Mimosa, Grande Rapids, Camila, Sabrina, Grande Lagos, Regina, e Quatro Estações). O delineamento experimental adotado foi blocos ao acaso em esquema de parcelas subdividas, sendo, as diferentes fontes de adubação (parcelas) e cultivares (subparcelas), com quatro repetições. Avaliaram-se o diâmetro da cabeça (cm), biomassa fresca da cabeça (g planta-1), número de folhas e produtividade estimada (ton.ha-1). Não houve efeito significativo da interação adubação x cultivar sobre as variáveis analisadas. As cultivares Grandes Lagos e Grandes Rapids apresentaram maior produção de biomassa fresca da cabeça e produtividade que as demais. A alface respondeu positivamente a adubação orgânica e o composto bokashi foi o que proporcionou melhores ganhos em crescimento e produtividade para a cultura. A utilização de esterco bovino também produziu bons resultados no desempenho da cultura representando mais uma possibilidade a ser utilizada pelo produtor.
PARÂMETROS DE CRESCIMENTO E CURVA DE ABSORÇÃO DE NUTRIENTES DE MUDAS DE MOGNO AFRICANO COM E SEM SOLUÇÃO NUTRITIVA
Authors: Smiderle Oscar José , Souza Aline Das Graças , Chagas Edvan Alves , Alves Marcia Souza , Fagundes Paulo Roberto O. 
Published: August 2019

O objetivo deste trabalho foi determinar parâmetros de crescimento e a curva de absorção de nutrientes de mudas Khaya senegalensis com e sem solução nutritiva. O delineamento experimental utilizado foi de parcelas subdivididas no tempo, dispostas em delineamento inteiramente casualizado, com quatro repetições. Dois tratamentos dispostos nas parcelas foram representados com e sem solução nutritiva e, nas subparcelas, os tratamentos foram representados por seis épocas de avaliação (0, 60, 80, 100, 120 e 140 dias após o transplantio). Foram avaliados os parâmetros: altura das mudas, diâmetro de caule, massa seca da parte aérea, radicular e total, relação massa seca da parte aérea/massa seca de raiz e índice de Dickson bem como a curva de absorçãode N, P, K, Ca, Mg e S na parte aérea e radicular. Mudas de Khaya senegalensis cultivadas com adição de solução nutritiva expressaram maior crescimento em altura e bem como o diâmetro de caule coleto e índice de qualidade de Dickson, resultando em maior vigor das mudas.
CARBONO LÁBIL E FRAÇÕES OXIDÁVEIS DE CARBONO EM SOLOS CULTIVADOS SOB DIFERENTES FORMAS DE USO E MANEJO
Authors: De Oliveira Taine Pereira , Ensinas Simone Cândido , Barbosa Giselle Feliciani , Nanzer Marina Chiquito , Barreta Paulo Gabriel Vechetin , Silva Maiara Fernada Garcia , Queiroz Gustavo Reis Silva dos Santos , Do Prado Eber Augusto Ferreira 
Published: August 2019

O presente trabalho teve como objetivo quantificar e comparar os teores e estoques de carbono lábil e carbono nas frações F1, F2 e F3 da matéria orgânica do solo em um Neossolo Quartzarênico sob diferentes usos e manejos. Foram coletadas amostras de solo nas camadas 0-10, 10-20 e 20-30 cm nas áreas de: vegetação nativa de Cerrado, seringueira solteira (Hevea brasiliensis), seringueira consorciada com abacaxi (Ananas comosus), pastagem de Brachiaria sp., com 30 anos, pastagem de Brachiaria brizanta cv. Marandu com 3 anos e área cultivada com amendoim em sistema de preparo convencional. As diferentes formas de uso e manejo do solo influenciaram os teores e estoques de carbono lábil e as frações oxidáveis da matéria orgânica do solo. O sistema de preparo convencional proporciona menores teores de carbono lábil no solo. A utilização do solo com pastagens proporciona incrementos nos teores e estoques de carbono nas frações mais recalcitrantes da matéria orgânica do solo.
La fenomenología del espíritu y su posibilidad de acceso al reino de la ética. Un primer acercamiento a la Filosofía del derecho de G. W. F. Hegel
Authors: Ávila Martínez Alexánder 
Published: August 2019

El presente artículo quiere mostrar una primera aproximación ala filosofía del derecho de G. W. F. Hegel. La aproximación se realiza através de la Fenomenología del espíritu y tiene como objetivo mostrar que el mundo de la ética se origina en el espíritu subjetivo. Al interior de tal proceso, se abordan siguiendo la dialéctica tres momentos: en el primero se estudia la dialéctica de mutuo reconocimiento entre autoconciencias, en el segundo se muestra la dialéctica del amo y del esclavo y sus repercusiones en las relaciones de poder, y en el tercero, a partir de la razón se muestra cómo con la aparición de la ley que examina leyes se abre un escenario para la eticidad y para el espíritu objetivo. El artículo pretende dar solución a la cuestión: ¿Qué elementos de la Fenomenología del espíritu relacionados con el reino de la ética, se muestran importantes para la comprensión de la Filosofía del derecho de Hegel? La solución a tal hipótesis intentará resolverse con la utilización del método dialéctico y tomando como referente teórico principal la Fenomenología del espíritu de G. F. W Hegel, y como referentes secundarios Génesis y estructura de la Fenomenología del espíritu de Hegel de J. Hyppolite y La dialéctica del amo y del esclavo en Hegel de A. Kojéve.
Production Technology for Oat Protein with Advanced Physicochemical, Functional, and Technological Properties
Authors: Каширских Егор , Kashirskich Egor , Бабич Ольга , Babich Olga , Кригер Ольга , Kriger Olga 
Published: August 2019

The current intensive industrialization has changed the food preferences of consumers. As a result, there is a growing demand for high-grade high-nutritional meat and dairy products, which, in its turn, triggered an increase in the demand for grain crops and led to higher animal feed prices. All these affected the price and quality of the finished product, since farms are trying to stay profitable. As a consequence, the high cost of animal proteins make producers look for other sources of protein with similar qualities. Common oat (Avena sativa L.) remains the most cultivated species. Oats are a source of high-quality protein with an optimal amino acid balance. The paper features a oat protein technology (Avena sativa). The research defined the parameters of the protein extraction process. For acid and alkaline methods, the following optimum parameters were revealed: temperature – 40 ± 2°C, hydraulic module – 1:10, time – 90 minutes, active acidity of the acid extraction – 2.0 units, active acidity of alkaline extraction
–	9.0 units. The authors managed to obtain protein substances with the molecular weight > 50 kDa. The optimal parameters of ultrafiltration of the protein extract were as follows: pore diameter = 100 kDa at pH 8.0 and 0.5 MPa. The ultrafiltration conducted under these conditions showed that the content of high molecular fractions (globulins and albumins) increased from 39.12% to 55.15% for the extract obtained by alkaline method, whereas the content of low molecular weight fractions (prolamins and glutelins) decreased from 60.88% to 44.85%. Ultrafiltration of protein extracts obtained by alkaline and acidic methods made it possible to concentrate protein fractions with a molecular weight ≥ 50 kDa. When a 10% aqueous solution of succinic acid was used as a precipitator, the protein precipitation degree equaled 89.3%. The paper introduces a new oat protein purification method. The optimal multiplicity of purification by RP-HPLC was 4 purification cycles. For the alkaline extract, the total content of high molecular weight fractions (50.0–120.0 kDa) was 72.7% and the total content of low molecular weight fractions (15.0–49.0 kDa) was 27.3%. For the acid extract, the total content of high molecular weight fractions was 72.9%, while the content of low molecular weight fractions was 27.1%. Oat proteins obtained by alkaline and acid extraction demonstrated a high foaming ability (148–177%) at pH = 6.0–9.0, as well as a good fat and water retention capacity. The oat proteins were found to have a high content of protein and essential amino acids similar to animal proteins. A comparative analysis showed that oat protein can act as an alternative substitute for animal proteins.
ŻYCIE I TWÓRCZOŚĆ WŁADIMIRA KORWIN-PIOTROWSKIEGO
Authors: Venclova Tomas , Dubyk Halyna 
Published: August 2019

“Life and Writings of Vladimir Krowin-piotrowski”The paper presents a profile of Vladimir Krowin-Piotrowski, a significant twentieth century poet, now forgotten. He is known mostly to researchers of the emigre literature, as he played a key role in the short lived flourishing of ‘Russian Berlin’, when he was part of the inner circle of Vladimir Nabokov.
Детерминанты социально-политической активности современной молодежи
Authors: Усова Наталия 
Published: August 2019

Introduction. This paper presents a hierarchical model of socio-political activity of contemporary youth based on the system-diachronic approach. The author developed and tested a new diagnostic tool for measuring the degree of activity, intentionality, and destructiveness in subjects of social, public, and political life – a questionnaire on young people’s socio-political activity.
Methods. The study employed qualitative and quantitative data collection methods, standardized questionnaires, and inventories. The data collected were processed using content analysis and secondary mathematical and statistical analysis.
Results. Age, income, education level, professional activity, patriotic consciousness, absence of political infantilism, absence of achievement and power motivations, satisfaction with living conditions, dissatisfaction with leisure sphere and partner relationships, and focusing on emotions together determine the transition from socio-political passivity to socio-political activity. The transition from a destructive form of socio-political activity to a constructive one is determined by dominance of values ​​of individualism and individualistic orientation, consumption in leisure, low confidence in authorities, high power motivation, absence of affiliation motivation, high satisfaction with education and professional activity, emotional stress caused by living conditions and social climate, and certain behavioral strategies, including repression, suppression, and use of sedatives. The transition from an unintentional socio-political activity to an intentional one is associated with reflection, socio-political competence, political socialization, high achievement and power motivations, dissatisfaction with leisure sphere and professional activity in the absence of emotional stress caused by living conditions, and a high propensity to plan.
Discussion. Various combinations of determinants form the types of subjects of socio-political activity who are characterized by different correlations among the degree of activity, intentionality, and of the constructiveness of its manifestations. This thesis enabled the author to describe characteristics of different types of young people’s socio-political activity.
Factores que influyen en la adopción de innovaciones en productores de naranja en Ãlamo, Veracruz
Authors: Mercado Escamilla Fidelia , Ayala Garay Alma Velia , Flores Trejo Arturo , Oble Vergara Evelia , Almaguer Vargas Gustavo 
Published: August 2019

En Veracruz, los rendimientos por unidad de superficie se hanÂ mantenido prácticamente estables por más de 34 años y al determinarÂ los factores que influyen en esto se encontró que ladeficiente adopción de innovaciones es lo más importante. ConÂ la finalidad de mejorar dicha adopción se aplicó una encuestaÂ de línea base inicial a 100 citricultores de diez localidades. PosteriormenteÂ se brindó extensionismo integral durante un añoÂ mediante el uso de bitácoras de seguimiento y al terminar seÂ aplicó la encuesta de línea base final. Se logró incrementar laadopción de innovaciones tecnológicas en 30.5 % en promedio,Â ya que se mejoraron la fertilización y control de plagas yÂ enfermedades, principalmente. Para determinar factores queinfluyen en la adopción de innovaciones se generaron modelosÂ de regresión simple, utilizando como variable dependienteÂ el incremento en el índice de adopción de innovaciones y comovariables independientes los atributos específicos del productorÂ y de sus unidades de producción. El factor que tuvo correlaciónÂ significativa con el índice de adopción de innovaciones fue elingreso del productor. Los factores como edad, años de experienciaÂ y escolaridad no influyeron en la toma de decisiones paraÂ adoptar tecnologías.
Prevalensi hiperpigmentasi gingiva pada pasien perokok di klinik periodonsia RSGM FKG Unpad
Authors: Faruchy Annisa Ghea , Komara Ira , Pribadi Indra Mustika Setia 
Published: August 2019

Pendahuluan: Hiperpigmentasi gingiva merupakan pewarnaan pada gingiva berupa warna kecoklatan atau kehitaman berbentuk unit soliter atau pita bersambung yang berasal dari granula melanin yang diproduksi oleh sel-sel melanoblas, yang dapat disebabkan oleh faktor endogen dan faktor eksogen. Salah satu penyebab terjadinya hiperpigmentasi gingiva adalah merokok. Penelitian ini bertujuan untuk mengetahui prevalensi hiperpigmentasi gingiva pada pasien perokok di klinik Periodonsia RSGM FKG Unpad. Metode: Penelitian ini menggunakan metode deskriptif potong lintang dengan jumlah sampel sebanyak 49 orang. Subjek penelitian yang memenuhi kriteria ditanya beberapa pertanyaan mengenai kebiasaan merokoknya kemudian diperiksa keadaan gingivanya dan ditentukan klasifikasi hiperpigmentasi gingivanya bedasarkan klasifikasi Hedin. Hasil: Hasil penelitian ini menunjukkan sebagian besar subjek penelitian mengkonsumsi rokok 1-10 batang per hari dan telah merokok lebih dari 10 tahun. Jenis rokok yang banyak dikonsumsi oleh subjek dalam penelitian ini adalah rokok kretek. Nilai hiperpigmentasi gingiva dengan jumlah terbanyak adalah 4, dan jumlah terkecil adalah 0. Simpulan: prevalensi hiperpigmentasi gingiva pada pasien perokok di klinik Periodonsia RSGM FKG Unpad adalah 89,8%.Kata Kunci: Prevalensi, hiperpigmentasi gingiva, perokok
СТАЊЕ ПРЕМЈЕРА НА ТЕРИТОРИЈИ ОПШТИНЕ ЗВОРНИК
Authors: Andrić Marija , Marinković Goran 
Published: August 2019

У раду је дат кратак опис рада три Подручне јединице: Зворник, Билећа и Мркоњић Град. Акценат је стављен на Подручну јединицу у Зворнику. Описана је анализа стања катастра као и одржавање истог. Подручне јединице у РС теже успостављању катастра непокретности, јер се још увијек води двојна евиденција. Примарни циљ истраживања је утврђивање квалитета старог премјера и његова употребљивост у савременом условима.