bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of Microleakage in Posterior Nanocomposite Restorations with Adhesive Liners
Authors: Reyal Sandeep , Gupta Ashu , Singh Bhanu 
Published: October 2018

AbstractMicroleakage is the clinically detectable passage of bacteria, fluids, molecules or ions between a cavity wall and the restorative materials applied to it. This study was conducted to evaluate and compare the microleakage in Class II nanocomposite restorations, with resin-modified glass ionomer liner(group I), nanofilled flowable composite liner(group II) & without liner(group III). Thirty six non carious upper premolar teeth extracted for orthodontic purposes were selected. Standard class II cavities were prepared. The teeth were then randomly & equally divided into three groups with 12 teeth in each group. The teeth were subjected to thermocycling. After that apex of each tooth was sealed with acrylic resin and the teeth were painted with two coats of nail varnish, except for the area of 2 mm from the periphery of the restorations. The coated teeth were immersed in buffered (Ph 7) 0.5% methylene blue dye for 48 hours. Teeth were sectioned & observed under stereomicroscope of 10X magnification. At gingival level, Group I exhibited slightly lesser microleakage than group II but was not statistically significant. Group I showed no significant difference between microleakage at occlusal and gingival level (Z=1.732; P=0.083). However, in Group II and Group III, there was significantly greater microleakage at the gingival level (Z= 2.162 and 3.162; P=0.002 and 0.002, respectively). Both resin-modified glass ionomer and flowable composite can be used as liners under nano composite restorations as reduction in microleakage was comparable.
A Life Saving Tooth Extraction
Authors: Chhabra Vandana , Chhabra Ajay , Aggarwal Girish 
Published: October 2018

AbstractDentoalveolar surgery is accompanied by a number of complications, one of these is bleeding. The majority of patients who bleed after extractions do not have any underlying haematological disorders and generally have had extractions previously without complications, suggesting a purely local factor in the occurrence of haemorrhage; e.g, local infection, traumatic surgery and noncompliance to postoperative instructions. Here we report a case of 14 year old female patient who reported to our department for ortho extraction and after atraumatic tooth extraction the blood continued to ooze for hours. All the local measures failed to control the oozing. Dengue has become a global problem since the second world war. No antiviral drugs or vaccine has been invented so far. The range of the disease appears to be expanding possibly due to climate change.
Psychological Implications in Parents of Cleft Lip and Palate Children
Authors: Behal Roobal , Khan Asif , Utreja Ashok 
Published: October 2018

Abstract
Objective: To determine quality of life of parents of children with cleft lip and palate and to compare it with parents of non cleft lip and palate children. Method: World Health Organisation Quality of Life (Bref, Field Trial version,1996) for parents of children with cleft lip and palate. Total of 40 parents were questioned, 20 were parents of CLP chidren and the other 20 were parents of non cleft children. Results: The scores of quality of life for parents of the cleft children were significantly lower than the parents of non-cleft children. Conclusion: The parents of children with clefts had a lower Quality of Life score as compared to the parents of children with no clefts.
Free Gingival Autograft for Augmentation of Keratinized Tissue and Stabilization of Gingival Recession - 2 Case Reports
Authors: Gupta Hemant , Aggarwal Sangeeta , Singla Ruby , Kochhar Sumit , Kaur Sukhvinder 
Published: October 2018

AbstractIn the current practice of periodontics, clinicians are faced with the challenge of not only addressing biological and functional problems present in the periodontium, but also providing therapy that results in acceptable aesthetics. The presence of mucogingival problems and gingival recession around anterior, highly visible teeth exemplifies a situation in which a treatment modality that addresses both biological and aesthetic demands is required from the therapist. Periodontal plastic surgery procedures are performed to resolve these mucogingival problems. This paper presents two cases of gingival recession (Miller's class I and class II) successfully treated with complete root coverage by free gingival autografts.
Estimation of Vertical Dimension of Occlusion in Edentuleous Patients Using Cephalometric Analysis
Authors: Batra Ritu , Kalra Sanjay , Bansal Ajay , Nerula Siddharth , Dang Rajat 
Published: October 2018

Abstract“The best of friends fall out with time and so do teeth.”Thus, there is a need to replace the lost teeth and the supporting structures for the patient's social demands and functional rehabilitation. Prosthetic treatment with complete dentures is a very common treatment modality; the biggest challenge in its fabrication is to duplicate the normal vertical dimension. Failure can be avoided by completing the treatment without changing the vertical dimension and obtaining an optimal facial proportion. There are many methods to record VD. Radiographic cephalometry has been used as a diagnostic tool in Prosthodontics for over five decades and numerous authors, like Ricketts (1981), McNamara (1984) and Slavicek (1984) developed and computerized these techniques to co-relate and record VD in patients. However cephalometric analysis can help to visualize skeletal and facial proportion relation. The present study was done to use the lateral radiographs with cephalometric analysis, as it could be a simple, non-technique sensitive, non-invasive and atraumatic way to determine VD for complete denture patients and also to compare physiologic methods (swallowing/phonetics) with cephalometric method to record lower facial height.
Treatment of Early-Onset Hip Osteoarthritis in Young Patients
Authors: Brown Timothy , Miniaci Anthony , Westermann Robert , Day Molly 
Published: October 2018

AbstractPain and debilitating symptoms due to hip osteoarthritis (OA) can significantly compromise quality of life in young, active patients. The management of the young adult with hip OA presents a unique set of challenges, with symptoms that originate from a variety of underlying hip pathologies, and patient age spanning from youth through middle age. Early options for hip OA include nonoperative treatment with anti-inflammatory medications, physical therapy, and injections. For patients with structural hip abnormalities (femoroacetabular impingement or dysplasia), arthroscopy or reconstructive osteotomy are acceptable treatment options. In advanced disease, joint-preserving techniques are often ineffective, and patients may require joint resurfacing or replacement. The treatment strategies for early hip OA continues to evolve with the development of new and refined surgical techniques, especially in the setting of underlying hip pathology, and a growing popularity of utilizing biologic agents. The purpose of this manuscript is to review current conservative and surgical management and to describe an algorithm for treatment of early-onset hip OA.
The Association between Maternal Height, Body Mass Index, and Perinatal Outcomes
Authors: Marshall Nicole , Biel Frances , Boone-Heinonen Janne , Dukhovny Dmitry , Caughey Aaron , Snowden Jonathan 
Published: October 2018

Objective To test the hypothesis that maternal height is associated with adverse perinatal outcomes, controlling for and stratified by maternal body mass index (BMI).
Study Design This was a retrospective cohort study of all births in California between 2007 and 2010 (n = 1,775,984). Maternal height was categorized into quintiles, with lowest quintile (≤20%) representing shorter stature and the uppermost quintile (≥80%) representing taller stature. Outcomes included gestational diabetes mellitus (GDM), preeclampsia, cesarean, preterm birth (PTB), macrosomia, and low birth weight (LBW). We calculated height/outcome associations among BMI categories, and BMI/outcome associations among height categories, using various multivariable logistic regression models.
Results Taller women were less likely to have GDM, nulliparous cesarean, PTB, and LBW; these associations were similar across maternal BMI categories and persisted after multivariable adjustment. In contrast, when stratified by maternal height, the associations between maternal BMI and birth outcomes varied by specific outcomes, for example, the association between morbid obesity (compared with normal or overweight) and the risk of GDM was weaker among shorter women (adjusted odds ratio [aOR], 95% confidence interval [CI]: 3.48, 3.28–3.69) than taller women (aOR, 95% CI: 4.42, 4.19–4.66).
Conclusion Maternal height is strongly associated with altered perinatal risk even after accounting for variations in complications by BMI.
Politics and the Popular in British Music Theatre of the Vietnam
Era
Authors: Adlington Robert 
Published: October 2018

AbstractBritish music-theatre works of the 1960s and early 1970s largely avoided direct
engagement with contemporary political topics. Intriguing in this light is
Michael Hall’s recent proposition that Brecht’s music theatre set
the terms for younger British composers’ experiments with the genre.
Brecht proved a complicated model, however, because of composers’
anxieties about music’s capability to convey sociopolitical messages, and
their reluctance to accord popular music a progressive function. The
entanglement of Vietnam War activism and rock music forms the backdrop for
analyses of two works that do address Vietnam directly: Anthony Gilbert’s
The Scene-Machine and George Newson’s
Arena (both 1971) – both of which also pass pointed
comment on different popular-music traditions. Both works highlight the
difficulty in emulating Brecht’s model in an era when the concept of
‘the political’ was being significantly redefined, and the
cultural gap between activist cadres and the wider population was
unprecedentedly visible.
Age‐specific response of skeletal muscle extracellular matrix to acute resistance exercise: A pilot study
Authors: Wessner Barbara , Liebensteiner Michael , Nachbauer Werner , Csapo Robert 
Published: October 2018

AbstractThe extracellular matrix (ECM) plays an essential role in the development, growth and repair of skeletal muscles and serves to transmit contractile force. However, its regulation is poorly understood. This study investigates the age‐specificity of the effects of acute resistance exercise on ECM gene expression. To this purpose, five young (YM, 23.8 ± 2.2 yrs.) and 5 elderly (EM, 66.8 ± 4.1 yrs.) men performed one session of unilateral leg press and leg extension exercises. Six hours post‐exercise, biopsies were taken from the vastus lateralis muscles of both legs. A PCR array was used to profile the expression of 84 ECM‐related genes, of which 6 were validated by qPCR. The PCR array found 9 and 4 ECM‐associated genes to be selectively altered (>1.5‐fold change) in YM or EM only. Four further genes were upregulated in YM but downregulated in EM. Of the 6 genes validated on individual samples MMP9 expression increased in YM (9.7‐fold) and decreased (0.2‐fold) in EM. MMP15 was downregulated in EM only (0.6‐fold). A significant correlation between leg extension 1 RM and changes in COL7A1 expression (ρ = 0.71) suggests a potential influence of fitness levels. In conclusion, acute resistance exercise affects ECM gene expression at least partly in an age‐specific manner. The altered expression of genes encoding matrix metalloproteinases (MMP3, MMP9, MMP15) highlights the role of remodelling processes in the response to an acute bout of resistance exercise. Larger studies are required to verify the age‐associated differences in gene expression profiles and establish their functional implications.
sRNAPrimerDB: comprehensive primer design and search web service for small non-coding RNAs
Authors: Xie Shengsong , Zhu Qin , Qu Wubin , Xu Zhong , Liu Xiangdong , Li Xinyun , Li Shijun , Ma Wubin , Miao Yiliang , Zhang Lisheng , Du Xiaoyong , Dong Wuzi , Li Haiwei , Zhao Changzhi , Wang Yunlong , Fang Yaping , Zhao Shuhong 
Published: October 2018

Abstract

Motivation
Small non-coding RNAs (ncRNAs), especially microRNAs (miRNAs) and piwi-interacting RNAs (piRNAs), play key roles in many biological processes. However, only a few tools can be used to develop the optimal primer or probe design for the expression profile of small ncRNAs. Here, we developed sRNAPrimerDB, the first automated primer designing and query web service for small ncRNAs.

Results
The primer online designing module of sRNAPrimerDB is composed of primer design algorithms and quality evaluation of the polymerase chain reaction (PCR) primer. Five types of primers, namely, generic or specific reverse transcription primers, specific PCR primers pairs, TaqMan probe, double-hairpin probe and hybridization probe for different small ncRNA detection methods, can be designed and searched using this service. The quality of PCR primers is further evaluated using melting temperature, primer dimer, hairpin structure and specificity. Moreover, the sequence and size of each amplicon are also provided for the subsequent experiment verification. At present, 531 306 and 2 941 669 primer pairs exist across 223 species for miRNAs and piRNAs, respectively, according to sRNAPrimerDB. Several primers designed by sRNAPrimerDB are further successfully validated by subsequent experiments.

Availability and implementation
sRNAPrimerDB is a valuable platform that can be used to detect small ncRNAs. This module can be publicly accessible at http://www.srnaprimerdb.com or http://123.57.239.141.

Supplementary information
Supplementary data are available at Bioinformatics online.
Sparse relative risk regression models
Authors: Wit Ernst C , Augugliaro Luigi , Pazira Hassan , González Javier , Abegaz Fentaw 
Published: October 2018

SummaryClinical studies where patients are routinely screened for many genomic features are becoming more routine. In principle, this holds the promise of being able to find genomic signatures for a particular disease. In particular, cancer survival is thought to be closely linked to the genomic constitution of the tumor. Discovering such signatures will be useful in the diagnosis of the patient, may be used for treatment decisions and, perhaps, even the development of new treatments. However, genomic data are typically noisy and high-dimensional, not rarely outstripping the number of patients included in the study. Regularized survival models have been proposed to deal with such scenarios. These methods typically induce sparsity by means of a coincidental match of the geometry of the convex likelihood and a (near) non-convex regularizer. The disadvantages of such methods are that they are typically non-invariant to scale changes of the covariates, they struggle with highly correlated covariates, and they have a practical problem of determining the amount of regularization. In this article, we propose an extension of the differential geometric least angle regression method for sparse inference in relative risk regression models. A software implementation of our method is available on github (https://github.com/LuigiAugugliaro/dgcox).
Neural Dynamics of Reward-Induced Response Activation and Inhibition
Authors: Wang Lihui , Chang Wenshuo , Krebs Ruth M , Boehler C Nico , Theeuwes Jan , Zhou Xiaolin 
Published: October 2018

AbstractReward-predictive stimuli can increase an automatic response tendency, which needs to be counteracted by effortful response inhibition when this tendency is inappropriate for the current task. Here we investigated how the human brain implements this dynamic process by adopting a reward-modulated Simon task while acquiring EEG and fMRI data in separate sessions. In the Simon task, a lateral target stimulus triggers an automatic response tendency of the spatially corresponding hand, which needs to be overcome if the activated hand is opposite to what the task requires, thereby delaying the response. We associated high or low reward with different targets, the location of which could be congruent or incongruent with the correct response hand. High-reward targets elicited larger Simon effects than low-reward targets, suggesting an increase in the automatic response tendency induced by the stimulus location. This tendency was accompanied by modulations of the lateralized readiness potential over the motor cortex, and was inhibited soon after if the high-reward targets were incongruent with the correct response hand. Moreover, this process was accompanied by enhanced theta oscillations in medial frontal cortex and enhanced activity in a frontobasal ganglia network. With dynamical causal modeling, we further demonstrated that the connection from presupplementary motor area (pre-SMA) to right inferior frontal cortex (rIFC) played a crucial role in modulating the reward-modulated response inhibition. Our results support a dynamic neural model of reward-induced response activation and inhibition, and shed light on the neural communication between reward and cognitive control in generating adaptive behaviors.
Tenascin-C accelerates adverse ventricular remodelling after myocardial infarction by modulating macrophage polarization
Authors: Kimura Taizo , Tajiri Kazuko , Sato Akira , Sakai Satoshi , Wang Zheng , Yoshida Toshimichi , Uede Toshimitsu , Hiroe Michiaki , Aonuma Kazutaka , Ieda Masaki , Imanaka-Yoshida Kyoko 
Published: October 2018

Abstract

Aims
Tenascin-C (TN-C) is an extracellular matrix protein undetected in the normal adult heart, but expressed in several heart diseases associated with inflammation. We previously reported that serum TN-C levels of myocardial infarction (MI) patients were elevated during the acute stage, and that patients with high peak TN-C levels were at high risk of left ventricular (LV) remodelling and poor outcome, suggesting that TN-C could play a significant role in the progression of ventricular remodelling. However, the detailed molecular mechanisms associated with this process remain unknown. We aimed to elucidate the role and underlying mechanisms associated with TN-C in adverse remodelling after MI.

Methods and results
MI was induced by permanent ligation of the coronary artery of TN-C knockout (TN-C-KO) and wild type (WT) mice. In WT mice, TN-C was expressed at the borders between intact and necrotic areas, with a peak at 3 days post-MI and observed in the immediate vicinity of infiltrating macrophages. TN-C-KO mice were protected from ventricular adverse remodelling as evidenced by a higher LV ejection fraction as compared with WT mice (19.0 ± 6.3% vs. 10.6 ± 4.4%; P < 0.001) at 3 months post-MI. During the acute phase, flow-cytometric analyses showed a decrease in F4/80+CD206lowCD45+ M1 macrophages and an increase in F4/80+CD206highCD45+ M2 macrophages in the TN-C-KO heart. To clarify the role of TN-C on macrophage polarization, we examined the direct effect of TN-C on bone marrow-derived macrophages in culture, observing that TN-C promoted macrophage shifting into an M1 phenotype via Toll-like receptor 4 (TLR4). Under M2-skewing conditions, TN-C suppressed the expression of interferon regulatory factor 4, a key transcription factor that controls M2-macrophage polarization, via TLR4, thereby inhibiting M2 polarization.

Conclusion
These results suggested that TN-C accelerates LV remodelling after MI, at least in part, by modulating M1/M2-macrophage polarization.
Relative resistance to breaking of Pinus taeda and Pinus palustris
Authors: Garms Cory , Dean Thomas J 
Published: October 2018

AbstractPatterns from hurricane damage indicate that longleaf pine is more windfirm than loblolly pine. Tree windfirmess has been attributed to many factors including species and material properties like wood strength and stiffness. Because longleaf pine wood is stronger and stiffer than loblolly pine wood, this study used static winching methodology to see if these properties account for differences in wind firmness by measuring bending force required to break stems (MMAX). Stress–strain diagrams were constructed for pulled trees to explore how they behave under increasing loads. Based on these diagrams, living trees appear to act as linear elastic materials as they experience increasing static lateral stress. As expected, longleaf pine stems were stiffer than loblolly pine wood in situ based on Young’s modulus of elasticity. Tree basal area was the best predictor of MMAX for both species, however, species had no significant effect on the maximum bending moment required to break tree stems of a given basal area for these trees under these conditions. The stiffness of the stems was higher for longleaf than loblolly as indicated by the modulus of elasticity, but the strength of the stems as indicated by the modulus of rupture was not significantly different between the species. Differences in the volumetric density of foliage, however, were consistent with the observed differences in stem failure between the species. For trees with the same diameter, loblolly pine had higher values of leaf area per unit crown length than longleaf pine.
Kit-independent mast cell adhesion mediated by Notch
Authors: Murata Akihiko , Hikosaka Mari , Yoshino Miya , Zhou Lan , Hayashi Shin-Ichi 
Published: October 2018

AbstractKit/CD117 plays a crucial role in the cell–cell and cell–matrix adhesion of mammalian mast cells (MCs); however, it is unclear whether other adhesion molecule(s) perform important roles in the adhesion of MCs. In the present study, we show a novel Kit-independent adhesion mechanism of mouse cultured MCs mediated by Notch family members. On stromal cells transduced with each Notch ligand gene, Kit and its signaling become dispensable for the entire adhesion process of MCs from tethering to spreading. The Notch-mediated spreading of adherent MCs involves the activation of signaling via phosphatidylinositol 3-kinases and mitogen-activated protein kinases, similar to Kit-mediated spreading. Despite the activation of the same signaling pathways, while Kit supports the adhesion and survival of MCs, Notch only supports adhesion. Thus, Notch family members are specialized adhesion molecules for MCs that effectively replace the adhesion function of Kit in order to support the interaction of MCs with the surrounding cellular microenvironments.
Epidemiology, Biology, Treatment, and Prevention of Ductal Carcinoma In Situ (DCIS)
Authors: Punglia Rinaa S , Bifolck Kaitlyn , Golshan Mehra , Lehman Constance , Collins Laura , Polyak Kornelia , Mittendorf Elizabeth , Garber Judy , Hwang Shelley E , Schnitt Stuart J , Partridge Ann H , King Tari A 
Published: October 2018

Abstract
Ductal carcinoma in situ (DCIS) is a highly heterogeneous disease. It presents in a variety of ways and may or may not progress to invasive cancer, which poses challenges for both diagnosis and treatment. On May 15, 2017, the Dana-Farber/Harvard Cancer Center hosted a retreat for over 80 breast specialists including medical oncologists, surgical oncologists, radiation oncologists, radiologists, pathologists, physician assistants, nurses, nurse practitioners, researchers, and patient advocates to discuss the state of the science, treatment challenges, and key questions relating to DCIS. Speakers and attendees were encouraged to explore opportunities for future collaboration and research to improve our understanding and clinical management of this disease. Participants were from Dana-Farber Cancer Institute, Brigham and Women’s Hospital, Massachusetts General Hospital, Beth Israel Deaconess Medical Center, Duke University Medical Center, and MD Anderson Cancer Center. The discussion focused on three main themes: epidemiology, detection, and pathology; state of the science including the biology of DCIS and potential novel treatment approaches; and risk perceptions, communication, and decision-making. Here we summarize the proceedings from this event.