bluuebunny/crossref_metadata_2025_split huggingface dataset:
Post-transcriptional regulation of miRNA-15a and miRNA-15b on VEGFR gene and deer antler cell proliferation
Authors: Liu Mingxiao , Han Xiangyu , Cui Dongming , Yan Yuduo , Li Lu , Hu Wei 
Published: November 2018

Abstract

Background
Deer antler is the only regenerative organ in mammals, the regeneration of antler is not only the regeneration of bone tissue, but also accompanied by the regeneration of nerves, blood vessels and so on. The purpose of the current study was to explore the effect of miRNA-15a and miRNA-15b on the regulation of sika deer vascular endothelial growth factor receptor (VEGFR) during rapid antler growth.

Materials and methods
The VEGFR 3′-UTR was analyzed by bioinformatics software to identify the highly matched miRNAs. After transfected with miRNA mimics, the expression of selected miRNAs were measured by RT-qPCR and the relative expression level of VEGFR protein was detected by Western Blot. Dual-luciferase activity assay was used to determine the target relationship between VEGFR and miRNAs. The cartilage cell proliferation and telomerase activity were measured by MTT kit and TRAP assay, respectively.

Results
The VEGFR 3′-UTR contains a binding site for miRNA-15a and miRNA-15b. Over-expression of miRNA-15a and miRNA-15b, which significantly reduced the expression level of VEGFR protein, inhibited the proliferation of cartilage cells, and decreased the telomerase activity of cartilage cells in vitro.

Conclusion
miRNA-15a and miRNA-15b represent novel regulatory factors of VEGFR expression in deer antler.
Synthesis of CdSe/ZnS@HPU-2 composites for highly sensitive and multicolor florescence response to Fe3+
Authors: Li Huijun , He Yaling , Li Qingqing , Xu Zhouqing , Wang Yan , Wang Yuan 
Published: November 2018

Abstract
A composite material based dual-emission probe for Fe3+ was prepared by the hybridization of a three-dimensional framework with CdSe/ZnS quantum dots (QDs)-doped silica nanoparticles. The obtained probe showed characteristic fluorescence emissions of CdSe/ZnS QDs (red) and Cd-metal-organic framework (MOF, blue) under a single exciation wavelength. Upon the detection of Fe3+, only the fluorescence of Cd-MOF was quenched, whereas the red fluorescence of CdSe/ZnS QDs particles was mostly reserved. Consequently, the variation of the two fluorescence intensity ratios displays a continuous color change from blue to red upon exposure to different amounts of Fe3+ ions, which can be easily observed under a UV lamp.
Synthesis and Characterization of BaAl2O4 Catalyst and its Photocatalytic Activity Towards Degradation of Methylene Blue Dye
Authors: Wang Shifa , Gao Huajing , Fang Leiming , Wei Yong , Li Yanwu , Lei Li 
Published: November 2018

Abstract
Hexagonal BaAl2O4 catalyst has been prepared using a gamma-ray irradiation assisted polyacrylamide gel method. The catalysts synthesized at different calcining temperatures were analyzed to insight into their effects on the structural, crystalline, surface morphology, color, optical, fluorescence and photocatalytic properties of the hexagonal BaAl2O4 catalyst. Increasing the calcining temperature has obvious influences on the crystallinity, color, optical properties and the formation of the hexagonal BaAl2O4 catalyst. The optical energy gap (Eg) value of the hexagonal BaAl2O4 catalyst increases with the increasing of calcining temperature. TEM image of the pure hexagonal BaAl2O4 catalyst shows a morphology of flake structure and aggregation. Raman spectroscopy of the pure hexagonal BaAl2O4 catalyst exhibits four luminescent background peaks at 400, 415, 428 and 445 nm mainly due to the oxygen vacancies (VO), Ba vacancies (VBa) and some color centers exists in the BaAl2O4 sample. A comparison of photocatalytic activity among samples for degradation of methylene blue (MB) dye indicates that the pure hexagonal BaAl2O4 catalyst exhibits highest photocatalytic activity under the irradiation of both visible and ultraviolet light. Based on the fluorescence experiment, electrochemical and active species tests, the high photocatalytic activity of the pure hexagonal BaAl2O4 catalyst to be related to hole (h+) and hydroxyl radical (⋅OH) and also to the defects in the sample.
Evaluating the Rutting Resistance of Wearing Course Mixtures with Different Fine Aggregate Sources Using the Indirect Tensile Strength Test
Authors: Tran Nhat Thanh , Takahashi Osamu 
Published: November 2018

Abstract
The aim of this experimental study was to determine if the indirect tensile (IDT) strength test results for Marshall cylindrical specimens are associated with a laboratory evaluation parameter for the rutting resistance of wearing course hot mix asphalt (HMA) mixtures. We investigated a wide range of HMA mixtures with various aggregate gradations; the specimens consisted of seven Vietnamese and six Indonesian HMA mixtures with a 12.5-mm nominal maximum particle size. Three different fine aggregates from two sources (natural sand and manufactured screening) were used to fabricate these HMA specimens. Wheel tracking tests were also conducted to verify the validity of the IDT strength test as a potential indicator of rutting resistance in HMA mixtures. The experimental results showed that the IDT strength test using Marshall cylindrical specimens has potential applications for evaluating rutting resistance, regardless of aggregate source. The study also explored the effects of fine aggregate on the resistance of HMA mixtures to permanent deformation. Overall, fine aggregate significantly influenced the rutting resistance of mixtures when the aggregate gradations were controlled to achieve the same gradations. In contrast, fine aggregates with different gradations were not strongly associated with the rutting resistance of HMA mixtures.
Deflective Whiteness: White Rhetoric and Racial Fabrication
Authors: Noel Hannah 
Published: November 2018

This article focuses on the ways that minority identity politics are co-opted, decontextualized, and used by those invested in white supremacy and white identity politics to further their own racial project in seemingly benign, everyday cross-media discourse. This pattern of discourse, which the author terms “deflective whiteness,” deflects the fear, discomfort, and aggression that those invested in white supremacy feel when confronted with systemic racism and inequity. This fear and discomfort are transposed onto individuals linked with identity-based social movements, who are then faulted for causing a social disruption. The vantage point of deflective whiteness deliberately avoids recognizing the mission or goals of the social movement, and the resulting decontextualized chastisement is categorized as “common sense.” In the process, the original protest against white supremacy and its effects is ignored and overshadowed by a colorblind critique of those invested in identity politics as weak, unpatriotic, and naïve.
The ENRICH Project: Blurring the Borders between Community and the Ivory Tower
Authors: Waldron Ingrid R. G. 
Published: November 2018

In the spring of 2012, the author agreed to direct a project on environmental racism in Nova Scotia after meeting with Dave Ron, a social and environmental activist who had been involved for some time in the Save Lincolnville Campaign, a community-led initiative for the removal of the landfill near the African Nova Scotian community of Lincolnville. Thirsty for a new challenge that had the potential to effect real change in racially marginalized communities, she understood that the significance of the project lay in its uniqueness: few, if any, studies exist that examine environmental racism in both the Indigenous and Black communities in Canada. Given the dearth of research on environmental racism in Nova Scotia, particularly from the perspectives of these two communities, the project serves as a kind of case study for telling a particular kind of story situated in the Nova Scotian context and, in many cases, in the larger Canadian context.That project, which was later titled the Environmental Noxiousness, Racial Inequities and Community Health (ENRICH) Project, is a community-based academic study of the socioeconomic and health effects of environmental racism in African Nova Scotian and Mi’kmaw communities. From its inception, the mission of the ENRICH Project has been to employ an interdisciplinary, multi-methodological approach that bridges the academy and community to support ongoing and new efforts by Mi’kmaw and African Nova Scotian peoples to address the social, economic, political, and health effects of disproportionate pollution in their communities.
Effect of hearing aid on balance
Authors: ŞAHİN Hasan , KARAMAN Hanifi 
Published: November 2018

Aim:
The aim of this study was to investigate the effects of hearing aid usage on
balance system in individuals older than 60 years of age who use hearing aid
due to presbiacusia.Materials and Methods: Individuals (&gt;60 years of age) with at least 25 dB
age-related sensorineural hearing loss in both ears and who were given
bilateral hearing aid for 3 months were included to our study. The data
obtained by evaluating balance system with cVEMP and Romberg on foam test prior
to the usage of hearing aid and 3 months after individuals used bilateral
hearing aid (without device condition) were compared. Results: While P1-N1 responses were not taken from 21 of the tested ears, they
were taken from 39 of the tested ears. Even though remarkable improvement was
found in Romberg on foam test done after 3-month usage of hearing aid
(p=0.001), no significant change was observed in cVEMP findings (p&gt;0.05)
other than the N1 latencies (p=0.03).

Conclusion: With the usage of hearing aid due to
presciacusia, an increase is seen in the ability of keeping balance parallel
with the increase in auditory inputs.
CURRENT TREND OF RESISTANT FOR THE COMMONLY PRESCRIBED NEW FLUOROQUINOLONES AMONG HOSPITALISED PATIENTS IN SANA'A, YEMEN
Authors: Alyahawi Ali , Alkaf Ali , Alnosary Taha 
Published: November 2018

The new fluoroquinolones have demonstrated enhanced activity against the most common bacteria involved in lower respiratory tract infection (LRTI). Moxifloxacin is the most commonly prescribed respiratory flouroquinolone drug in Yemen. Pneumonia is a major and an on-going public health problem globally. With the widely use of fluoroquinolones in the clinical practice, the potential for developing resistance has become a concern. The aim of present study was to determine the trend of moxifloxacin resistant and the distribution of resistant for different sample types among hospitalised patients in Sana'a, Yemen. The study was performed at a private hospital in Sana’a, Yemen. The records were taken from the microbiology department for hospitalised patients. Moxifloxacin susceptibility samples were collected from January, 2017 to December, 2017. The moxifloxacin susceptibility was studied against several isolates. Full ethical clearance was obtained from the qualified authorities who approved the study design. All data were analyzed using SPSS Statistics version 21. Out of 927 sample isolates, 580 (62.6%) were moxifloxacin resistant isolates and only 30.1% were sensitive. The Escherichia coli was observed in 24.4% of total sample isolates, followed by Pseudomonas aeruginosa (12.1%). From the study findings, 44.8% of total sample was isolated from sputum cultures.There was a statistically significant difference between bacteria type and culture results (P-value < 0.001). Moreover, 96.2% of Acinetobacter species and all Acinetobacter baumannii isolates were moxifloxacin resistant. The study findings reported that 70.4% of Escherichia coli isolates were resistant for moxifloaxin, followed by methicillin resistant staphylococcus aureus (64.7%), Klebsiella pneumonia (60.6%), and Pseudomonas aeruginosa (46.4%). However, 86.1% of staphylococcus aureus isolates were moxifloxacin resistant. Results in this study showed that there was high significantly relationship between culture results and sample type (P-value< 0.001). Also 44.8% of sample isolates were from sputum cultures. Moreover, 74.2% of sputum cultures isolates were moxifloxacin resistant. There was a statistically significant difference between culture results with age groups (P-value = 0.02). Also 64.1% of males had moxifloxacin resistant and 36.9% of isolate resistant were aged > 60 years. This study reveals that varieties of pathogens are responsible for LRTI and moxifloxacin resistance has become a great public health issue. The possibility of reducing resistance by controlling the use of antibiotics is a reasonable approach. Inappropriate and irrational drug usage should be avoided. This study may help the government’s regulatory authority to develop a policy about rational prescription of antibiotics to minimize resistance of new antibiotics and also to ensure the maximum safety to the health of patients.
PHYTOCHEMICAL SCREENING AND IN VITRO ANTIOXIDANT AND ANTI-DIABETIC POTENTIALS OF PERSEA AMERICANA MILL. (LAURACEAE) FRUIT EXTRACT
Authors: Rao US Mahadeva 
Published: November 2018

Diabetes mellitus (DM) is a metabolic disorder characterized by insulin resistance and pancreatic β-cell dysfunction and the management of blood glucose level is an important strategy in the control of the disease and complications associated with it. Therefore, components that cause uptake of glucose from the bloodstream and inhibitors of carbohydrate hydrolyzing enzymes can be useful in treatment of DM and medicinal plants are often used to achieve this aim. Avocado fruit is rich in phytochemicals necessary for treatment of DM. The purpose of this study was to investigate the inhibitory effect of Persea americana fruit extracts on α-amylase and α-glucosidase enzymes. The percentage yield, phytochemical screening (both qualitative and quantitative), in vitro antioxidant and anti-diabeticassays, and kinetic studies were performed with different solvent extracts of Avocado fruit pulp. Results: Avocado hadgreat and promising potential as pharmaceutical agent, particularly to be developed as anti-diabetic through the inhibition of α-glucosidase and α- amylase enzymes. In vitro studies of the antioxidant activity of the fruit extract gaveanevidence and strong biochemical rationale of their therapeutic potential. The fruit extract of P. americana may play an important role in the development of nutraceuticals and also in the management of oxidative stress induced DM.
COMPARATIVE ANALYSIS OF THE PHYTOCHEMICAL COMPOSITIONS OF LEAF, STEM-BARK AND ROOT OF AZADIRACHTA INDICA (NEEM)
Authors: ON. Nwali , A. Idoko , JE Okolie , E Ezeh , PO Ugwudike , ON Rita , MO Ezenwali , IA Odo , PN Ani , SO Okolie 
Published: November 2018

Plant chemicals abound in different parts of plants, in different compositions. Thus, the comparative screening of the leaf, stem-bark and root of Azadirachta Indica becomes imperative. The presence of nine phytochemicals which include; Alkaloids, Flavonoids, Saponins, Glycosides, Phenols, Steroids, Tannins, Reducing sugars and Anthraquinones, and the quantity of alkaloids, flavonoids, saponins, tannins and glycoside in the leaf, stem-bark and root of Azadirachta indica were investigated. The plant parts were collected from a plantation grown in Okpotegu Echara, Ikwo Local Government Area of Ebonyi State, Nigeria. Plant samples were air dried at room temperature, ground into uniform powder, sieved, bottled and labeled, ready for physico – chemical analysis. Results of the investigation revealed that anthraquinones were beyond detection limits in all the plant parts tested in both ethanol and aqueous extracts. Alkaloids were not detectable in leaf, stem-bark and root samples of aqueous extract. Glycosides were not detectable in leaf sample of ethanol and aqueous extracts. Quantitatively, the phytochemical compositions of each part showed higher concentrations of Alkaloids in the leaf, stem-bark and root (11.63%, 4.93% and 3.79%), compared to flavonoids (2.19%, 2.72% and 0.92%), saponins (0.70%, 1.12% and 0.44%), tannins (0.33 mg/100, 0.50mg/100 and 0.17mg/100) and glycosides (0.23%, 0.27% and 0.19%), respectively. Obviously, except for the higher percentage (11.63%) of alkaloids in the leaf, the phytochemicals in the stem-bark are higher as shown by the results, which could support the reason that the bark is preferably chewed commonly together with the stem as chew stick for its germicidal and antifungal action.
THE EFFECT OF TRAFFIC FACTORS AND TECHNOLOGY FACTORS ON CHRONOLOGICAL DELAY OF EMERGENCY (115) ON THE BESIDES OF INJURED PEOPLE IN BOYER AHMAD CITY IN 2017
Authors: Sadat Seyed Ehsan , Barzabad Parviz Aghayii , Asl Iravan Masoudi 
Published: November 2018

The aim of this study is to investigate traffic factors and technology factors on chronological delay of emergency (115) on the besides of injured people in Boyer Ahmad city in 2017. The research method of this investigation from the point of view related to target is operational and according to nature is descriptive-analytic. The target population is users of 115 emergency services of Boyer Ahmad city from the first of March to August2017. On the basis of the similar statistics of the first six months of 2016, 2240 people have used emergency services of Boyer Ahmad city that on the basis of Krejcie and Morgan table, 100 people will be chosen as statistical sample. In this study, data has been gathered by using researcher made questionnaire. At first, needed data has been achieved by responses to questionnaires and then study variables have been tested and analyzed by using SPSS statistical software and statistical methods in two sections of descriptive and perceptive. The results of the study indicated that there is a meaningful relation between environmental, relational and traffic factors and also between technological factors and 115 emergency delay on the patient’s beside in Boyer Ahmad city (p>0.05). As, the meaningfulness level and correlation coefficient between studied variables with 115 emergency delay respectively are: traffic factors (P=0.001, r=0.73), technology factors (P=0.001, r=0.62). So, research hypothesis is verified.
Effect of high-fat-fructose diet on synaptic plasticity in hippocampus and lipid profile of blood serum of rat: pharmacological possibilities of affecting risk factors
Authors: Micháliková D. , Kaprinay B. Tyukos , Lipták B. , Švík K. , Slovák L. , Sotníková R. , Bezek Š. , Gáspárová Z. 
Published: November 2018

Abstract
The aim of this study was to determine pharmacological possibilities of influencing the risk factors of metabolic syndrome (MetS). Hypertriacylglycerolemic (HTG) rats fed with high-fat-fructose diet (HFFD) were used as a model of the MetS. Wistar rats fed with standard diet were used as negative control group. HTG rats fed with HFFD for 8 weeks were used as positive control group. The effects of atorvastatin and SMe1EC2 were tested. The compounds were administered to the HTG rats after 5 weeks of HFFD, once a day for 3 weeks. After 8 weeks, the blood serum lipid profile and electrophysiology of neurotransmission in hippocampal sections were evaluated in vitro. SMe1EC2 and atorvastatin had a significant effect on total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-cholesterol) and atorvastatin had a significant effect on triacylglycerols (TGs). SMe1EC2 improved the long-term potentiation (LTP) course in the hippocampus.
Analysis of Long-Term Measured Exterior Air Temperature in Zilina
Authors: Jurasova Daniela 
Published: November 2018

Abstract
The climate change assumes nowadays on significance. Weather data may be available on various time scales – long-term, minutes, hours, days, periods, years. Measurements of air temperature are realized for a long time. Data in Slovakia are available from few weather stations of Slovak Hydrometeorological Institute (SHMI). For long-term and wide-ranging measurement of various parameters this can be complicated and expensive. This paper is focused on temperature measurement near the experimental laboratory. Estimation of daily, monthly and yearly mean temperatures is done in different ways. Results from experimental temperature measurement, in a way of selection of unusual extremes are presented. Shorter recording intervals describe the temperature courses in a more pertinent way.
Superoxide dismutase isoenzymes gene expression in peripheral blood mononuclear cells in patients with coronary artery disease
Authors: Ninić Ana , Bogavac-Stanojević Nataša , Sopić Miron , Munjas Jelena , Kotur-Stevuljević Jelena , Miljković Milica , Gojković Tamara , Kalimanovska-Oštrić Dimitra , Spasojević-Kalimanovska Vesna 
Published: November 2018

SummaryBackgroundCoronary artery disease (CAD) is one of the most important causes of mortality and morbidity in wide world population. Dyslipidemia, inflammation and oxidative stress may contribute to disruption of endothelium structure and function, atherosclerosis and CAD. Our study was aimed to determine whether Cu/Zn superoxide dismutase (Cu/Zn SOD) and Mn superoxide dismutase (Mn SOD) gene expression could be modulated by oxidative stress in CAD patients.MethodsThis study included 77 CAD patients and 31 apparently healthy persons. Serum lipid levels, high sensitivity C-reactive protein (hsCRP), total antioxidant status (TAS) and thiobarbituric acid-reacting substances (TBARS) were measured. SOD isoenzymes gene expression was determined in peripheral blood mononuclear cells using quantitative polymerase chain reaction.ResultsMn SOD messenger ribonucleic acid (mRNA) levels were significantly lower in CAD patients than in controls (p=0.011), while Cu/Zn SOD mRNA levels did not change significantly between tested groups (p=0.091). We found significantly lower high-density lipoprotein-cholesterol (HDL-c) (p<0.001) and TAS (p<0.001) levels and significantly higher hsCRP (p=0.002) and TBARS (p<0.001) in CAD patients than in controls. There were significant positive correlations between TAS and Mn SOD mRNA (ρ=0.243, p=0.020) and TAS and Cu/Zn SOD mRNA (r=0.359, p<0.001). TBARS negatively correlated only with Cu/Zn SOD mRNA (ρ=-0.215, p=0.040). TAS levels remained independent predictor for Mn SOD mRNA levels (OR=2.995, p=0.034).ConclusionsResults of this study showed that Mn SOD gene expression were decreased in CAD patients compared to controls and can be modulated by non-enzymatic antioxidant status in blood.
Genetic changes in pigeon paramyxovirus type-1 induced by serial passages in chickens and microscopic lesions caused by the virus in various avian hosts
Authors: Olszewska-Tomczyk Monika , Dolka Izabella , Świętoń Edyta , Śmietanka Krzysztof 
Published: November 2018

Abstract

Introduction: Genotype VI of avian avulavirus 1 (AAvV-1) has pigeons and doves as its reservoir and is often termed pigeon paramyxovirus type-1 (PPMV-1). The pathogenesis of PPMV-1 infections in poultry is largely obscure. It is known that PPMV-1 requires a series of passages in chickens before it becomes adapted to gallinaceous poultry.

Material and Methods: Changes in the genome of PPMV-1 were analysed after serial passages in specific pathogen free (SPF) chickens, using high-throughput sequencing. Additionally, histopathological lesions induced by PPMV-1 in experimentally inoculated pigeons, chickens, and turkeys were evaluated.

Results: Following six passages of PPMV-1 in chickens, 10 nonsynonymous substitutions were found including one (in the NP protein) which dominated the genetic pool of viral quasispecies. Histopathological changes induced by the post-passage PPMV-1 strain were more prominent than changes wrought by the pre-passaged PPMV-1 strain and the lesions were most intense in pigeons followed by chickens and turkeys.

Conclusion: PPMV-1 is highly adapted to pigeons and passaging through chickens results in the acquisition of novel amino acids in the polymerase complex, which may alter the pathogenic potential of the virus.