bluuebunny/crossref_metadata_2025_split huggingface dataset:
Abstract 4144502:
Comparing Readmission Rates and Exercise Capacity Following Left Ventricular Assistive Device Placement With and Without Post-Operative Inpatient Rehabilitation
Authors: Cuenant Lauren , Raja Junaid , Tiozzo Eduard , Pontee Nicole 
Published: November 2024

Introduction:
Patients with heart failure may undergo mechanical assistive device placement as a bridge to heart transplantation or for destination therapy. Thereafter, patients may be discharged home or admitted to inpatient rehabilitation.

Research Question:
We hypothesized that within 8 months, patients admitted to inpatient rehabilitation (IR) would have fewer readmissions and greater exercise capacity compared to patients discharged home following left ventricular assistive device (LVAD) placement.

Aim:
The readmission rates and exercise capacity of patients admitted to (IR) were compared to those discharged home within 8 months of (LVAD) placement.

Methods:
Readmission rates, impairment percentages (IP) (determined by Activity Measure for Post-Acute Care scores) and walking distance after (LVAD) placement between March 1
st
, 2020 to November 30
th
, 2022 were collected via retrospective chart review at Jackson Memorial Hospital.

Adults with heart failure and heart assistive device (ICD10 code Z95.811), discharged home or admitted to the Christine E. Lynn Rehabilitation Center for at least 7 consecutive days within 8 months were included. Patients who were noncompliant, expired, transferred, or unable to ambulate were excluded. 24 patients were admitted to rehab, and 16 were discharged home. Statistical significance was denoted at the 0.05 level using the Mann-Whitney U Test.

Results:
There was a higher proportion of females in the rehab group (45.8%) and males in the no rehab group (93.8%) (p=0.02). The groups were otherwise comparable.

Average (IP) at hospital discharge was higher for the rehab group (51.79%, SD 17.65) compared to the no rehab group (14.20%, SD 18.93) (p<.001). Average post-(LVAD) walking distance (feet) at hospital discharge was higher for the no rehab group (305, SD 206.72) compared to the rehab group (127.73, SD 132.11) (p=0.005). Within 8 months, there was no significant difference between groups.
Average readmissions were higher for the no rehab group (1.375, SD 0.957) compared to the rehab group (0.958, SD 1.49) (p= 0.059), but was not statistically significant.

Conclusions:
Patients with greater (IP) and shorter walking distances were admitted to rehab and became functionally comparable to the no rehab group by 8 months. Though readmission rates were lower for the rehab group, this was not statistically significant. Additional studies are warranted to evaluate the impact of (IR) following (LVAD) placement.
Abstract 4145857: The effect of homebase exercise training on single ventricle heart (SVH) function, exercise performance, body composition and quality of Life in children and adolescents living with a Fontan circulation
Authors: Ng Li Yen , McMahon Colin , James Adam 
Published: November 2024

Objectives:
Fontan patients have impaired exercise capacity. Exercise training has been shown to improve exercise performance. We aim to determine the effect of exercise training on SVH function, and its correlation with exercise capacity, body composition and self-reported QOL.

Methods:
31 paediatric Fontan patients were prospectively recruited to complete 3x30 minute homebased HIIT sessions per week for 20 weeks. Baseline physical activity levels, including structured sports participation, daily step-counts and active-zone-minutes (AZM) were recorded by accelerometer (Fitbit inspire3). Patients were considered active if they met 2 of the 3 criteria:

1/Structured sports training ≥ 2 per week (moderate-vigorous intensity >30 minutes)
2/Daily steps ≥ 10k
3/AZM ≥60 minutes per day
Bio-impedance-analysis, cardiopulmonary exercise tests, echocardiography including deformation imaging and PedQL questionnaires were performed at baseline and upon completion.

Results:
28 participants completed the programme. 86% had good compliance (completed >45/60 sessions). 17 male (60.7%), mean age 14.3±2.03 years, 14 LV-dominant, 14 non-LV dominant (9RV, 5BiV). No serious adverse events reported.

The exercise duration improved from 7.56±2.6 to 9.16±2.5 minutes, p<0.001 and peak workload from 110±43.6 to 129±45.8 watts, p<0.001. Indexed oxygen consumption (VO
2
/kg peak) improved from 30.9±7.1 to 32.2±7ml/min/kg, p=0.003 and oxygen pulse, O
2
pulse
peak
from 9.1±2.6 to 9.7±3 mL/beat, p<0.001. Submaximal analysis showed normal %predicted VO2 (>40%) and improvement of O
2
pulse, p=0.024.

LV systolic function showed improved MAPSE from 1.65±0.2 to 1.86±0.2, p=0.017, and improved apical rotation from 2.3±3.8 to 5.9±3.1, p=0.043. RV systolic function showed improved TAPSE of 1.4±0.2 to 1.6±0.3, p=0.032 and FAC of 44±5.6% to 49±10.5%, p=0.170.
Self-reported QOL scores were higher in Fontan children who were physically active at baseline, with a downward trend noted when poor compliance was evident (Child’s QOL V3.0 91.21±0.7 to 86.1±5.2, p=0.018 (Table 2).
Although no significant change in body composition, a higher appendicular skeletal muscle mass, SMMa% and lower body fat% were noted pre and post exercise training in the active Fontan group (Table 3),

Conclusions:
We observed significant improvements in both the submaximal and peak exercise performance in paediatric Exercise training associated with improvement of single ventricle longitudinal systolic function and ventricular mechanics.
Abstract 4147602: The Paradox Role of Sirtuin 6 In Coronary Microvascular Function under Metabolic Stress
Authors: Wang Yang , Enrick Molly , Gadd James , Nagy Blessing , Ogunmiluyi Iyanuoluwa , Yin Liya 
Published: November 2024

Coronary microvascular dysfunction (CMD), which is associated with diabetic cardiomyopathy, Takotsubo cardiomyopathy, andheart failure with preserved ejection fraction (HFpEF), is understudied. CMD is characterized by impaired endothelial-dependent vasodilation, but detailed mechanisms have yet to be elucidated.
Nuclear Sirtuin 6 (SIRT6) plays essential roles in gene transcriptional, stress tolerance, DNA repair, inflammation, and aging. SIRT6 is strongly associated with cardiovascular pathologies, but how SIRT6 regulates endothelial metabolisms and homeostasis under metabolic stress and the underlying mechanism remains poorly understood. It might be because global Sirt6 knockout mice are perinatally lethal caused by hypoglycemia, suggesting the essential role of SIRT6 in glucose metabolism.

In our preliminary studies, we generated inducible global Sirt6 knockout mice by crossing with Sirt6 f/f mice with CAG-cre (Sirt6
f/f, CAG
), and mice were viable with normal glucose levels. However, they showed impaired endothelial-dependent dilation (EDD) and impaired coronary flow reserve (CFR), an index clinically used to diagnose CMD. It suggests that deletion of Sirt6 might cause EC dysfunction because Sirt6 is reported to protect EC from premature senescence and oxidative stress by sustaining high eNOS levels. Surprisingly, when we studied non-inducible Sirt6 endothelial-specific knockout (Sirt6
f/f, tie-2 cre
) and inducible Sirt6 endothelial-specific knockout (Sirt6 f/f,
Cdh5-cre/ERT2
) and wild-type (WT) mice, Sirt6
f/f, Tie-2
and Sirt6
f/f, Cadh5
mice do not phenocopy the inducible global SIRT6 knockout mice, they had normal EDD and CFR. When the mice were fed a high fat and high sugar (HFHS) diet, the Sirt6
f/f, Tie-2
and Sirt6
f/f, Cadh5
had impaired EDD, suggesting Sirt 6 functioned differently in the mice fed with chow diet or HFHS diet.

We hypothesize Sirt 6 deficiency causes coronary endothelial dysfunction and contributes to CMD; activating Sirt6 will ameliorate CMD. EDD was assessed using myography (DMT). Myocardial blood flow (MBF) was measured by Doppler. Our preliminary data show that the mediator of coronary vasodilation switched from NO to H
2
O
2
in the Sirt6 knockout mice with impaired EDD. Interestingly, when the mice fed on HFHS were treated with Sirt 6 activator MDL-800, the coronary microvascular function was improved, and the blood glucose level was decreased. The underlying mechanism and the pathways involved will be elucidated.
‘Obligatory Relegation’, ‘Willing Translation’, or ‘Unreserved Declaration’? The Place of Religious Ideas in Public Square Deliberation
Authors: Fong Edmung 
Published: November 2024

Abstract
This paper describes three basic positions that have been held in relation to the place of religious ideas and reasons in public square deliberation by outlining the arguments of major representatives of each position. The three positions are: ‘obligatory relegation’ (Robert Audi); ‘willing translation’ (John Rawls and Jürgen Habermas), and ‘unreserved declaration’ (Nicholas Wolterstorff and Charles Taylor). I conclude by offering an observation from the survey. Even as the question of the place of religious ideas in public square deliberation can be approached from either broader domains of the secularisation/post-secularisation of societies or the essence of liberal democracy, it is not the domain itself but rather specific conceptions of key ideas or notions within each domain that push the representatives to take the position that they do.
Planting Seeds in a New Land
Authors: Greene Alexander M. 
Published: November 2024

Abstract
Around 1,000 Hmong refugees arrived in French Guiana in the late 1970s to found two agricultural communities. They were members of an emerging global diaspora of survivors fleeing the violence of the Laotian Civil War. From the perspective of the French government, the relocation became linked with the contemporaneous “Plan Vert” to develop the agricultural potential of the overseas territories. At that time, a significant percentage of the produce consumed in French Guiana was imported from Suriname. Within a few decades, government support helped the Hmong communities of Cacao and Javouhey to develop into critically important agricultural producers. Today they supply more than half of French Guiana’s produce, which has helped to eliminate dependence on imports from Suriname. In the early 2010s, the Surinamese government collaborated with Hmong leaders from French Guiana to bring a new wave of Hmong immigrants from Laos to Suriname. Their project, mirroring that of the French government nearly 40 years before, was to reinvigorate the agricultural sector by reclaiming land abandoned during the Surinamese Interior War of 1986–92. These waves of Hmong agricultural immigration are part of a long and ongoing history of displacements and mobilizations of groups of people by colonial and postcolonial governments in the Guianas. At the same time, the ongoing success of Hmong communities in the Guianas cannot be wholly attributed to government support: it is as much due to the dynamism and initiative of the Hmong themselves.
1. The Onomasticon with and without yahu Names
Authors: Hornkohl Aaron D. 
Published: November 2024

The chapter examines the evolution of Hebrew onomastics, with special focus on the use of Yahwistic names (names containing the divine element Yhwh) in the Bible. Apparently early biblical texts, like the books of the Torah, Joshua, Judges, and Samuel, contain very few Yahwistic names, in contrast to monarchic and post-exilic periods, where such names are prominent. Th absence of Yahwistic names in Genesis–Samuel suggests that they reliably reflect pre-monarchic naming traditions in which yahu names had yet to become common. One may thus hypothesise three stages in yahu naming practices: pre-monarchic rarity; widespread use of names ending in the long form -yahu during the Divided Monarchy; and ascendancy of names ending in the short form -yah in post-exilic times.
Scholars debate the significance of these patterns, with some suggesting that the Torah and other pre-monarchic texts preserve naming conventions from before 900 BCE. This challenges certain versions of the dating of Pentateuchal sources in the framework of the Documentary Hypothesis, which propose later dating for certain sources, and, to a lesser extent, the dominant dichotomous theory concerning BH linguistic periodisation. Despite the lack of direct extrabiblical Hebrew evidence from the pre-monarchic period, the absence of Yahwistic names in biblical texts depicting pre-monarchic times finds indirect confirmation in contemporary Mesopotamian and other ancient Near Eastern writings, supporting the idea that the Hebrew naming traditions found in Genesis–Samuel, which differ from those of the later monarchic and post-exilic periods, are authentically representative of pre-monarchic times.
4. Construct מְאַת versus Absolute מֵאָה
Authors: Hornkohl Aaron D. 
Published: November 2024

The cardinal numeral ‘hundred’ in ancient Hebrew presents two distinct forms: construct מְאַת and absolute מֵאָה. Their usage is not random, as evidenced by the distribution in biblical and extrabiblical texts. In Iron Age II epigraphic Hebrew, the construct form appears in a single instance, whereas the Masoretic Text (MT) shows a notable difference in the ratio of construct to absolute forms, with the construct outnumbering the absolute in the Pentateuch (27:5), but being less common in other parts of the MT (3:48). The analysis reveals that certain nouns only co-occur with one of the forms, and among the nouns that appear with both, the overall ratio is relatively balanced at 26:21, although the Torah significantly favours the construct.
The examination of various sources, including the Dead Sea Scrolls (DSS), Samaritan Pentateuch (SP), and Rabbinic Hebrew (RH), further elucidates the evolution of these forms. Due to harmonistic tendencies, the SP shows a higher occurrence of the construct form than the MT, while RH exhibits a strong preference for the absolute form. Notably, RH seldom uses the construct outside of direct allusion to Biblical Hebrew. The diachronic data indicates that while both forms were used in Classical Biblical Hebrew, the construct form fell out of favour in later sources. The linguistic distinction between the Torah and the rest of the Hebrew Bible also emerges as a significant observation, revealing a preference for the construct in the Torah that is not mirrored in other texts, highlighting the unique characteristics of the linguistic context in which the Torah was composed or, at the very least, the conservatism of its linguistic tradition.
7. 1CPL ונ ְ חַנ versus ונ ְ חַנ ֲ א
Authors: Hornkohl Aaron D. 
Published: November 2024

In Biblical Hebrew (BH), there are three notable forms of the first-person plural independent subject pronoun: standard אֲנַחְנוּ and non-standard נַחְנוּ and אנו. Each of the forms finds support beyond BH, whether in other forms of ancient Hebrew or cognate languages. Additionally, the development of two of these forms is the subject of an interesting linguistic debate, with differing opinions on whether אֲנַחְנוּ or נַחְנוּ is the more archaic form, reflecting varying theories on their historical usage and evolution.
The evidence suggests that while נַחְנוּ may be older, אֲנַחְנוּ became established as the standard form in Classical Biblical Hebrew (CBH). The fact that the Tiberian Pentateuch preserves minority cases of נַחְנוּ (in quoted speech), matching the only form found in Iron Age II Hebrew epigraphy, whereas the rest of CBH, along with the Samaritan Pentateuch, consistently resorts to אֲנַחְנוּ is taken here as evidence of sub-chronolects. Analysis of the purported sources of the Pentateuch indicates that all sources primarily employ the standard form, with instances of נַחְנוּ appearing mostly in the J and P sources.
9. FPL -ן versus - הָנ
Authors: Hornkohl Aaron D. 
Published: November 2024

The text discusses the prevalence and characteristics of the feminine plural (FPL) verbal suffix forms in ancient Hebrew. The dominant form across various ancient Hebrew sources, including the Tiberian biblical tradition and the Mishna, is vowel-final -נה. However, there exists a minority alternative, consonant-final -ן, whose presence and distribution within the biblical text, especially in the Masoretic tradition, is explored.
The analysis also presents statistical data illustrating the distribution of these forms in the Tiberian biblical tradition. It shows that vowel-final spellings dominate overall, while consonant-final forms are particularly concentrated in the Pentateuch. The text posits that these forms may reflect historical linguistic diversity in Hebrew that later evolved into a standardisation favouring vowel-final morphology. It suggests that the differing frequencies of consonant-final forms in the Torah compared to other biblical texts could indicate a preservation of older linguistic characteristics. The chapter concludes by raising questions about the implications of such morphological variation for theories of literary formation and textual transmission.
12. Orthography
Authors: Hornkohl Aaron D. 
Published: November 2024

The chapter explores the orthography of the Tiberian Torah in relation to other biblical texts, emphasising the linguistic and diachronic distinctiveness of the written component within the Masoretic tradition. It argues that while features discussed in chapters 8–11 might be viewed as purely orthographic peculiarities, they are better understood as linguistic differences. But even so, the distinctive defective orthography of the Torah, especially when compared to the more plene orthography in the rest of the Masoretic Bible, suggests that the spelling conventions of the Torah are conservative and may reflect an earlier stage of the Hebrew language. The presence of secondary developments in orthography raises questions about the authenticity and reliability of these conventions, but there remains a possibility of discerning meaningful early data amidst these changes.
The text further delves into various examples of pre-Tiberian and proto-Tiberian orthography, drawing evidence from biblical manuscripts, including the Dead Sea Scrolls, which illustrate more defective spellings than the Masoretic Text. Studies on the orthographic distinctiveness of the Tiberian Torah reveal that its conservative defectiveness correlates with early spelling conventions, particularly in Priestly material. While some scholars argue that orthographic variations can be attributed to secondary processes, the overall findings suggest that the orthographic conservatism of the Torah may be indicative of its antiquity. The distinction between the orthography of the Torah and the Former Prophets suggests a nuanced interplay of diachronic developments within the Hebrew Bible, highlighting the complex relationship between language, orthography, and textual transmission.
Fibromyalgia, mood disorders and chronic damage are the main determinants of worse quality of life in systemic lupus erythematosus patients: Results from a cross-sectional analysis
Authors: Ceccarelli Fulvia , Ciancarella Claudia , Pirone Carmelo , Natalucci Francesco , Picciariello Licia , Garufi Cristina , Mancuso Silvia , Truglia Simona , Spinelli Francesca Romana , Alessandri Cristiano , Cont Fabrizio 
Published: November 2024

Objective As suggested by the EULAR recommendations, a comprehensive management of Systemic Lupus Erythematosus (SLE) should include the evaluation of disease activity, chronic damage, and quality of life (QoL). QoL is significantly impaired in SLE patients, even in those achieving a state of remission, suggesting the possible contribution of other factors. Thus, in the present study we aimed at analyzing QoL in a large SLE cohort by using LupusQoL, and at identifying the main determinant of poorer QoL. Methods We conducted a cross-sectional study by including consecutive SLE patients diagnosed according to the 2019 ACR/EULAR criteria. Clinical, laboratory and therapeutical data were collected. Disease activity was assessed by SLEDAI-2k, while chronic damage by the SLICC Damage Index (SDI). The diagnosis of fibromyalgia was made in accordance with the ACR criteria (2016). At the time of the enrollment, all patients completed the following questionnaires: LupusQoL to assess quality of life and hospital anxiety and depression scale (HADS) for anxiety and depression. Results Our analysis included 237 SLE patients [92.4% female, median age 46 years (IQR 19.5), median disease duration 156.8 months (IQR 180.6)]. At the time of enrollment, we found a mean SLEDAI-2k of 1.7 (DS 2.4); 104 patients (43.9%) had chronic damage, with a mean SDI value of 0.8 (DS 1.3). Patients diagnosed with fibromyalgia were 69 (29.1%); moreover, HADS questionnaire identified a condition of anxiety and depression in 112 (47.3%) and 94 (39.7%) patients, respectively. The most compromised domain in the LupusQoL resulted “fatigue”, followed by “burden to others”. Patients with SDI ≥ 1 showed lower quality of life than patients without chronic damage, as demonstrated by significantly lower values in all items of the LupusQoL ( p < .01). Furthermore, significantly lower values in all the LupusQoL domains were observed in patients with fibromyalgia, anxiety and depression, in comparison to those patients without these manifestations ( p < .0001). No association was demonstrated between QoL and disease activity. Finally, the linear regression analysis confirmed mood disorders, in particular depression, and fibromyalgia as the main determinants of worse quality of life in our cohort. Conclusions The present study demonstrated the influence of different factors in the quality of life of SLE patients. In particular, the presence of mood disorders, fibromyalgia and chronic damage resulted the main determinants of poorer QoL. This evidence reinforces the need for a comprehensive patient care.
Interdisciplinary Rheumatoid Arthritis Research and Patient Care: An Introduction and Critique of the Biopsychosocial Model of Disease Experience in Rheumatoid Arthritis
Authors: McGarrity-Yoder Maureen , Insel Kathleen , Crane Tracy , Pace Thaddeus 
Published: November 2024

Introduction: Rheumatoid arthritis (RA), a debilitating autoimmune disease, affects approximately 78 million people globally. RA is often managed solely by rheumatology providers, but an interdisciplinary approach to RA may be the key to improving health equity and outcomes. An interdisciplinary model is an important step towards this goal. The Biopsychosocial Model of Disease Experience in RA (BDRA) is a conceptual approach that considers individual disease determinants in interdisciplinary research and care. Objective: To introduce and critique the evidence-based, interdisciplinary BDRA. Methods: Engel’s Biopsychosocial Model of Health (BMH) and the Revised Symptom Management Conceptual Model (RSMCM) were blended in the BDRA. A literature search of articles published prior to December 2021 was completed using “disease exacerbation,” “disease improvement,” and “disease activity” in RA. Results were categorized as biological, psychological, and social determinants of disease activity in RA. These biopsychosocial factors alter biological function and result in the individual RA experience. Model development and critique were completed using guidelines established by Walker and Avant. Conclusion: The BDRA is a visual depiction of RA biopsychosocial factors, disease activity, and individual experience. This model can guide interdisciplinary research and patient care, in efforts to improve RA health equity and rates of sustained remission.