bluuebunny/crossref_metadata_2025_split huggingface dataset:
Influence of Tibial Component Position on Altered Kinematics Following Total Ankle Arthroplasty During Simulated Gait
Authors: Saito Guilherme , Sturnick Daniel , Deland Jonathan , Ellis Scott , Demetracopoulos Constantine 
Published: September 2018

Category: Ankle Arthritis Introduction/Purpose: Correct positioning of total ankle arthroplasty (TAA) implants has been associated with superior clinical outcomes. Furthermore, biomechanical studies have demonstrated that poor alignment of the components may lead to early component wear, compromising the longevity of the prosthesis. Malpositioning of TAA implants affects ligament engagement patterns and joint contact mechanics, possibly leading to altered joint kinematics. However, the correlation between implant position and ankle joint motion is still unclear. The objective of this study was to assess the effect of tibial component position on ankle kinematics following TAA during simulated gait. Methods: Eight mid-tibia cadaveric specimens were utilized in this IRB approved study. The stance phase of gait was simulated both pre- and post-TAA in each specimen using a six-degree of freedom robotic platform. Ground reaction forces and tibial kinematic from in vivo data were replicated while physiologic tendon force profiles were applied to each extrinsic ankle tendons by linear actuators instrumented. Ankle kinematics was measured from reflective markers attached to bones via surgical pins. TAAs were completed using a common fixed-bearing total ankle system following the manufacturer recommended protocol (Salto Talaris, Integra LifeSciences). Using reconstructed CT data, 3D tibial component position relative to a standard ankle joint reference was characterized (Figure 1A). The effect of tibial component position on absolute differences in ankle kinematics (pre – post TAA) was assessed using linear regression with a level of significance set to p = 0.05. Results: Differences in ankle joint kinematics were only identified in the transverse plane, where internal talar rotation was significantly increased following TAA compared to the native condition (Figure 1B). The medial position of TAA tibial components was found to be positively associated with increased internal talar rotation (Figure 1C; β = 1.861 degrees/mm, R2 = 0.72, p = 0.008). No other measurements of tibial component position (anterior-posterior/inferior-superior position, sagittal/frontal/transverse plane angle) were found to be significantly associated with altered ankle kinematics following TAA (All β < 0.1 and p > 0.05). Conclusion: This study suggests that medial positioning of the tibial implant affects ankle kinematics. During operative procedures the tibial component is usually positioned in order to preserve bone stock of the medial and lateral malleolus. However, little attention is given to the position of the implant in relation to the center of the tibial axis. This finding could have clinical implications for techniques implemented during surgical procedures and for the development of new instrumentation systems.
Concentrated Bone Marrow Aspirate May Decrease Postoperative Cystic Occurrence Rate in Autologous Osteochondral Transplantation for Osteochondral Lesions of the Talus
Authors: Shimozono Yoshiharu , Hurley Eoghan , Kennedy John 
Published: September 2018

Category: Ankle Introduction/Purpose: Autologous Osteochondral Transplantation (AOT) provides excellent clinical outcomes for osteochondral lesions of the talus (OLT), however, there is concern regarding the presence of cysts at the bone interface. The presence of subchondral bone cysts has been previously shown to be correlated with graft failure, and high rates of postoperative subchondral cysts formation of up to 75% at short-term follow-up have been reported. Concentrated bone marrow aspirate (CBMA) may have the potential to improve integration between the graft and native articular cartilage and bone, and may reduce interface cyst production. The purpose of this study was to clarify the efficacy of CBMA in AOT as compared with AOT alone, regarding the presence of postoperative cyst formation, postoperative functional outcomes and magnetic resonance imaging (MRI) outcomes. Methods: Patients who underwent AOT between 2004 and 2008 were retrospectively assessed at a minimum of 5-year follow-up. Twenty-eight patients were treated with AOT and CBMA (AOT/CBMA group) and 26 patients were treated with AOT alone (AOT alone group). Clinical outcomes were evaluated using the Foot and Ankle Outcome Scores (FAOS) and Short-Form 12 (SF-12) preoperatively and at final follow-up. Postoperative MRI was evaluated with the modified Magnetic Resonance Observation of Cartilage Repair Tissue (MOCART) scoring system. Cystic formation was evaluated on postoperative MRI, and cyst diameter and cyst location were assessed. Results: Fifty-four of 59 eligible patients were included. Of those, 28 patients were treated with AOT and CBMA and 26 patients were treated with AOT alone. The mean FAOS and SF-12 significantly improved in both AOT/CBMA and AOT alone groups, but there were no statistical differences between groups in FAOS (80.6 vs 75.4, p = 0.217) and SF-12 (71.1 vs 69.2, p = 0.694) at final follow-up. Additionally, there was no difference in the mean MOCART Score (80.4 vs 84.3, p = 0.484). However, AOT/CBMA did result in a statistically lower rate of cyst formation (46.4% vs 76.9%, p = 0.022) (Table 1). No statistical differences were found between groups in cyst location and cyst diameter (table 1). Conclusion: CBMA reduced the postoperative cystic occurrence rate in patients treated with AOT, although CBMA did not result in significant differences in functional outcomes nor MOCART score in patients who underwent AOT.
The Presence and Degree of Bone Marrow Edema Influence on Midterm Clinical Outcome Following Microfracture for Osteochondral Lesions of the Talus
Authors: Shimozono Yoshiharu , Hurley Eoghan , Kennedy John 
Published: September 2018

Category: Ankle Introduction/Purpose: Subchondral bone marrow edema (BME) has been associated with articular cartilage loss, with the potential to be a negative prognostic indicator for clinical outcome following microfracture. However, no single study has investigated the influence of BME on clinical outcome following microfracture for osteochondral lesions of the talus (OLT) at mid-term follow-up. The purpose of this study was to clarify the influence of postoperative subchondral BME on the clinical outcome in patients treated with microfracture for OLT at both short- and mid-term. Methods: Patients who underwent microfracture between 2008 and 2013 were assessed at 2- and 4-year postoperative follow-up. BME was evaluated using magnetic resonance imaging (MRI), and the presence of subchondral BME was determined with fat-suppressed T2-weighted sequences. BME was graded on a 0-3 scale based on the relation to total talar volume as follows: 0, no BME; 1, <25% of talar volume; 2, 25%<, >50% of talar volume; 3, >50% of talar vome. Clinical outcomes were evaluated using the Foot and Ankle Outcome Scores (FAOS). The influence of postoperative subchondral BME on the clinical outcomes were evaluated as following; 1) the FAOS between the BME and the no BME groups were compared at 2 and 4 years post surgery, 2) the FAOS based on the BME grades were compared at each time point, and 3) correlation between the FAOS and BME grade was evaluated at each time point. Results: Forty-three (83%) of 52 eligible patients were included. No significant differences were found in FAOS between BME and no BME groups at 2-year follow-up (p=0.109), but there was a significant difference at 4-year follow-up (p = 0.041). A significant difference was found among BME grades at 4-year follow-up (p=0.035) (Table 1). A post hoc analysis showed significant differences between grade 0 and 2, 0 and 3, and 1 and 3 (p=0.041, 0.037 and 0.048, respectively). In addition, at 4-years follow-up, a significant correlation was noted between FAOS and BME grade (r= -0.453, p = 0.003) (Table 1), but not at 2-years (r = -0.212, p = 0.178). Seventy-four percent of patients still had subchondral BME at 4-year follow-up after microfracture for OLT. Conclusion: Patients with the presence of subchondral BME at mid-term follow-up after microfracture for OLT had worse clinical outcomes than those without subchondral BME. In addition, the degree of subchondral BME at mid-term follow-up was correlated with clinical outcome. However, in the short-term follow-up, there were no significant differences in clinical outcomes based on both the presence and degree of BME. The current study suggests that BME at short-term follow-up is a normal physiologic reaction. However, BME at mid-term following microfracture for OLT may be pathological, and is related to poorer clinical outcomes.
The Effect of Fibular Osteotomy on Talus Position in Supramalleolar Osteotomy
Authors: Sung Ki-Sun , Kim Dae-Wook 
Published: September 2018

Category: Ankle Arthritis Introduction/Purpose: A supramalleolar osteotomy (SMO) creates angulation and translation of the ankle joint. However, when the fibular osteotomy was not performed, the amount of shifting of the osteotomized fragment might be limited by the fibula. We use three different radiographic parameters to evaluate the extent of lateral translation of the talus in coronal plane after SMO with or without fibular osteotomy. Methods: Forty-two patients (44 cases) that were followed for more than 6 months after SMO with or without fibular osteotomy were retrospectively reviewed. Their mean (range) age and mean follow-up period were 55.6 years (24–74 years) and 19.9 months (6–84 months), respectively. The American Orthopedic Foot and Ankle Society (AOFAS) Ankle Hindfoot score was used for clinical evaluation of the patients. The radiological evaluations included tibial anterior surface (TAS) angle, tibial lateral surface (TLS) angle, talar tilt (TT) angle, tibiocrural (TC) angle, tibio-talar center (TTC) angle, talar center migration (TCM), talar translation ratio (TTR), and Takakura stage. We compared the improvements of the clinical and radiographic parameters between the two groups according to fibular osteotomy, and we assessed the types of complications after surgery. Results: The improvement of the AOFAS Ankle Hindfoot score was 29.9 ± 17.4 in the fibular osteotomy(FO) group and 26.1 ± 13.8 in the fibular preservation (FP) group, without significant difference between the two groups (p = 0.481). The FO group showed a significant improvement in Takakura stage, TAS angle, TT angle, TC angle, TTC angle, TCM, and TTR. No postoperative complication was found in the FO group, but one metal failure was observed in the FP group. Conclusion: Fibular osteotomy showed more satisfactory lateral translation of the talus after SMO and decreased Takakura stage, although the AOFAS Ankle Hindfoot score was not significantly different. Therefore, SMO with fibular osteotomy could result in better radiological parameters in coronal plane for varus ankle osteoarthritis.
Fresh Allograft Replacement for Osteochondral Lesions of the Talus
Authors: Adams Samuel , Allen Nicholas , Nunley James , Easley Mark 
Published: September 2018

Category: Basic Sciences/Biologics Introduction/Purpose: Large osteochondral lesion of the talus (OLT) can be difficult to treat. Although many treatment options exist, fresh osteochondral allograft transplantation has demonstrated promise as the primary treatment for OLTs with substantial cartilage and bone involvement as well as a secondary treatment option after failure of other cartilage repair techniques. Fresh osteochondral allografts are size-matched from organ donors and, in theory, have healthy articular cartilage and bone. However, the quality of allograft cartilage and bone has never been examined with respect to the OLT cartilage and bone being replaced. The purpose of this study was to perform a matched comparison of the cartilage and bone from patients OLTs to the fresh osteochondral allograft replacement. Methods: Discarded intact osteochondral specimens were collected from 8 patients undergoing surgery for an OLT. The specimens included the excised OLT and a portion of the fresh allograft replacement that the same patient received at the time of surgery. Histologic analysis was performed. The safranin-o histology was then scored using the International Cartilage Repair Society (ICRS) histopathology grading and staging system. In this system the grade determines cartilage and bone destruction on a scale of 0 to 6.5, the stage determines the percentage of involvement in the specimen on a scale of 0 to 4, and the total score is the grade multiplied by the stage. The surface roughness was also compared between the OLT and allograft cartilage using ImageJ software (NIH). Paired t-tests were performed on the ICRS grade, stage, and total score, and surface roughness comparing the OLTs and allografts. Significance was set at p<0.05. Results: Gross histological inspection of the samples demonstrated cartilage erosion and subchondral bone destruction in the OLTs. In constrast, the osteochondral allografts demonstrated intact cartilage surface and normal subchondral bone in the allografts (Figure 1). The ICRS grade, stage, and total score were significantly higher in the implanted allografts compared to the resected OLTs (Figure 2); indicating better cartilage and bone morphology for the allografts compared to the OLTs. In fact, the mean grade and stage for the allograft samples were both less than a score of 1 which corresponds to healthy cartilage and bone with less than 10% surface fibrillations. Moreover, the surface roughness of the allograft cartilage was significantly smoother than the OLT cartilage. Conclusion: This is the first study to demonstrate that the use of fresh allograft transplantation for the treatment of OLTs replaces the damaged cartilage and bone with normal or near normal cartilage and bone. The replacement of damaged cartilage and subchondral bone with normal or near normal cartilage and bone may be the reason for improved pain relief and functional outcomes after fresh allograft transplantation for OLTs.
Radiological outcome from Tight-RopeTM fixation for acute syndesmotic injury
Authors: Bae Su-Young , Chung Hyung Jin , Lee Jung-Hwan , Shin Woo-Jin , Junseok Lee 
Published: September 2018

Category: Trauma Introduction/Purpose: The reduction and maintenance of tibiofibular joint is essential in the treatment of syndesmotic ankle injury. Tight-RopeTM (Arthrex, Naples, FL, USA) has been used recently but suspected in terms of tightening and sustaining power in spite of biomechanical results. We aimed to assess fixation-tightness and delayed syndesmotic widening after rehabilitation in syndesmotic injuries treated with Tight-RopeTM comparing with conventional screws. Methods: 62 consecutive patients with acute syndesmotic injury were retrospectively reviewed. They were divided into 28 cases of Tight-RopeTM(TR) group and 34 cases of conventional screw fixation(Screw) group. We divided them into subgroups along the fixation methods such as 2 screws, 1 screw, TR only, and TR combined with screw. We analyzed syndesmotic widening by percentage. We measured tibiofibular clear space(TFCS) and tibiofibular overlap(TFOL). Tibiofibular clear space ratio and tibiofibular overlap ratio is measured as a ratio of tibiofibular clear space and tibiofibular overlap to the width of talar dome at preoperative, immediate postoperative, 3 months, and last (one year) visit time points and measured as a percentage of each measured value on the injured side to that on the contralateral side at the respective time points. The independent t-test and paired t-test were used for statistical analysis. Results: Mean TFCS ratio at each time point was 145.7±43.8%, 80.6±29.3%, 95.2±32.5%, and 96.3±31.1% in TR group and 126.2±42.6%, 73.9±22.6%, 104.8±59.2%, 106.4±35.0% in screw group. There were no statistical differences between groups in all 4 time points, no meaningful difference between subgroups. TFCS widening at 3 months in TR was less than screw group but no statistical significance. The TFCS was significantly tightened postoperatively then widened at 3 months and no meaningful change until last visit on both group. Mean TFOL ratio at each point was 51.84±43.6%, 119.2±36.7%, 110.7±44.5%, 96.8±27.7% in TR and 65.7±34.5%, 110.8±36.6%, 114.2±45.6%, 102.4±37.8% in screw group. There was no statistical difference between groups and subgroups. The overlap was increased postoperatively and no change between every sequential time points until last visit. Conclusion: The Tight-RopeTM fixation has a similar tightening and sustaining power compared to conventional screws and it was determined that the sustaining capacity did not decreased with time. Tight-RopeTM fixation can be effective treatment because it enables effective fixation, early weight-bearing and rehabilitation after surgery, and maintaining device for longer time in severe injury.
Realignment osteotomy in fibular malunion
Authors: Barg Alexej , Wiewiorski Martin , Valderrabano Victor 
Published: September 2018

Category: Ankle Arthritis Introduction/Purpose: The incidence of fibula fractures continues to increase. The exact incidence of distal fibula malunions after fibular reconstructions is not known, but incidence up to 33% is described in the literature. The most frequent malunions of the fibula are shortening and malrotation, resulting in the widening of the ankle mortise and talar instability. It has been demonstrated that substantial fibular displacement may substantially increase the contact pressures in the ankle joint. Therefore distal fibular malunion is a risk factor for development of posttraumatic ankle osteoarthritis. The objectives of this study were to (1) describe our treatment algorithm and surgical technique in patients with posttraumatic fibula malunions; (2) determine intra- and postoperative complications rates, (3) to describe mid-term clinical and radiological outcomes and quality of life. Methods: 21 consecutive patients (12 male, 9 female, mean age 42 years) with symptomatic fibular malunions were included into this prospective study. The initial injury was Weber B and C fracture in 7 and 14 ankles. The mean time between the injury and reconstructive surgery was 17.5 months. In all patients a z-shaped osteotomy of the fibula was performed to achieve the appropriate length/rotation of the fibula. Fixation was performed using a plate. If necessary, supramalleolar and inframalleolar deformities were corrected by supramalleolar tibial and calcaneal osteotomies, respectively. Prior to the osteotomies an anterior ankle arthroscopy was performed in all patients. All patients were evaluated pre- and postoperatively (mean follow-up 5.6 years). Radiological outcomes were assessed using standardized weight-bearing radiographs. Clinical outcomes were assessed using visual analogue scale (VAS), American Orthopaedic Foot and Ankle Society (AOFAS) hindfoot scale, SF-36 questionnaire. Results: There were no intraoperative complications. In two patients early wound healing problems were observed, and resolved with i.v. antibiotics. Osseous healing was observed in all ankles within 10 weeks after surgery. The length and rotation of the fibula was improved in all patients, according to Weber criteria. All patients experienced significant pain relief (VAS: 6.5 ± 1.1 to 1.1 ± 0.9, P < 0.001) and functional improvement (AOFAS hindfoot scale: 47.1 ± 14.5 to 85.0 ± 7.5, P < 0.001; ROM:37° ± 6° to 45° ± 5°, P < 0.001). The SF-36 score also significantly increased in all 8 subgroups. In 11 patients hardware was removed due a discomfort after a mean of 11.7 months (range 7.2 – 22.8). Conclusion: A z-shaped osteotomy is an efficient and successful method to restore fibula length and rotation in patients with posttraumatic malunion. Our findings in this series of 19 ankles confirm that this realignment surgery results in significant pain relief and functional improvement.
Patient Knowledge Regarding Radiation Exposure from Orthopaedic Foot and Ankle Imaging
Authors: Bohl Daniel , Manning Blaine , Holmes George , Lee Simon , Lin Johnny , Hamid Kamran 
Published: September 2018

Category: Other Introduction/Purpose: Foot and ankle surgeons routinely prescribe diagnostic imaging that exposes patients to potentially harmful ionizing radiation. The purpose of this study is to characterize patients’ knowledge regarding radiation exposure associated with common forms of foot and ankle imaging. Methods: A survey was administered to all new patients prior to their first foot and ankle clinic appointments. Patients were asked to compare the amount of harmful radiation associated with chest x-rays to that associated with various types of foot and ankle imaging. Results were tabulated and compared to actual values of radiation exposure from the published literature. Results: A total of 890 patients were invited to participate, of whom 791 (88.9%) completed the survey. The majority of patients believed that a foot x-ray, an ankle x-ray, a “low dose” CT scan of the foot and ankle (alluding to cone-beam CT), and a traditional CT scan of the foot and ankle all contain similar amounts of harmful ionizing radiation to a chest x-ray (Table 1). This is in contrast to the published literature, which suggests that foot x-rays, ankle x-rays, cone beam CT scans of the foot and ankle, and traditional CT scans of the foot and ankle expose patients to 0.006, 0.006, 0.127, and 0.833 chest x-rays worth of radiation. Conclusion: The results of the present study suggest that patients greatly over-estimate the amount of harmful ionizing radiation associated with plain film and cone-beam CT scans of the foot and ankle. Interestingly, their estimates of radiation associated with traditional CT scans of the foot and ankle were relatively accurate. Results suggest that patients may benefit from increased counseling by surgeons regarding the relatively low risk of radiation exposure associated with plain film and cone-beam CT imaging of the foot and ankle.
Authorship and Citations in Foot and Ankle International from 1980-2017
Authors: Bohl Daniel , Wakefield Connor , He Emily , Movassaghi Kamran , Holmes George , Lin Johnny , Hamid Kamran , Lee Simon 
Published: September 2018

Category: Other Introduction/Purpose: Orthopaedic foot and ankle surgery is a young and rapidly evolving orthopaedic subspecialty. Little is known regarding the authors contributing to the field. The purpose of this study is to characterize the demographics of the authors publishing foot and ankle research since the inception of the research journal of the American Orthopaedic Foot and Ankle Society. Methods: All publications in the journal Foot and Ankle International between 1980 and 2017 were reviewed. Papers were characterized in terms of number of authors, number of institutions, and number of references. The first and corresponding authors were also characterized in terms of country of origin, gender, and degree qualification. Each of these characteristics was tested for trends over time. Results: In total, 5,323 publications were reviewed, including 4,297 research articles, 367 case reports, 262 editorials, 159 letters, and 121 technique tips. The mean number of authors per paper increased from 2.3 during the 1980s to 4.3 during the 2010s (p<0.001). The percent of publications with female first authors increased from 4.9% during the 1980s to 13.2% during the 2010s (p<0.001). The country of origin shifted markedly away from the United States during the 1980s towards Europe and other countries during the 2010s (Figure 1). Podiatrists consisted of 1.3% of first authors and 1.4% of corresponding authors—these proportions did not meaningfully change over time (p>0.05). The mean number of references to other work increased from 13.8 during the 1980s to 24.4 during the 2010s (p<0.001). Conclusion: The authors of the foot and ankle literature have changed markedly over the past 4 decades. Most notably, there have been shifts towards female and international authorship. The number of authors per paper has also nearly doubled over time. Such trends are likely to continue as the field of foot and ankle grows.