bluuebunny/crossref_metadata_2025_split huggingface dataset:
Epidemiology and Survival of Systemic Sclerosis-Systemic Lupus Erythematosus Overlap Syndrome
Authors: Alharbi Samar , Ahmad Zareen , Bookman Arthur A. , Touma Zahi , Sanchez-Guerrero Jorge , Mitsakakis Nicholas , Johnson Sindhu R. 
Published: July 2018

Objective.Systemic sclerosis (SSc) may overlap with systemic lupus erythematous (SLE). Little is known about the epidemiology, clinical characteristics, and survival of SSc-SLE overlap. We evaluated the prevalence of SSc-SLE overlap and differences in SSc characteristics, and compared survival with SSc without SLE.Methods.A cohort study was conducted including subjects who fulfilled the American College of Rheumatology (ACR)/European League Against Rheumatism classification criteria for SSc and/or the ACR criteria for SLE. The primary outcome was time from diagnosis to all-cause mortality. Survival was evaluated using Kaplan-Meier and Cox proportional hazard models.Results.We identified 1252 subjects (SSc: n = 1166, SSc-SLE: n = 86) with an SSc-SLE prevalence of 6.8%. Those with SSc-SLE were younger at diagnosis (37.9 yrs vs 47.9 yrs, p < 0.001), more frequently East Asian (5.5% vs 20%) or South Asian (5.1% vs 12%), had lupus anticoagulant (6% vs 0.3%, p < 0.001), anticardiolipin antibody (6% vs 0.9%, p < 0.001), and pulmonary arterial hypertension (PAH; 52% vs 31%, p < 0.001). Those with SSc-SLE less frequently had calcinosis (13% vs 27%, p = 0.007), telangiectasia (49% vs 75%, p < 0.001), and diffuse subtype (12% vs 35%, p < 0.001). There were no significant differences in the occurrence of renal crisis (7% vs 7%), interstitial lung disease (ILD; 41% vs 34%), and digital ulcers (38% vs 32%). Those with SSc-SLE had better median survival time (26.1 vs 22.4 yrs), but this was not statistically significant (log-rank p = 0.06). Female sex and diffuse subtype attenuated survival differences between groups (HR 1.07, 95% CI 0.67–1.67).Conclusion.Patients with SSc-SLE are younger at diagnosis, more frequently have PAH, and less frequently have cutaneous manifestations of SSc. They should be monitored for ILD, renal crisis, and digital ulcers.
Cardiovascular Disease Prevention in Rheumatoid Arthritis: Compliance with Diabetes Screening Guidelines
Authors: Schmidt Timothy J. , Aviña-Zubieta J. Antonio , Sayre Eric C. , Abrahamowicz Michal , Esdaile John M. , Lacaille Diane 
Published: July 2018

Objective.To evaluate compliance with diabetes screening guidelines for cardiovascular disease (CVD) prevention in rheumatoid arthritis (RA) compared to the general population.Methods.We conducted the first longitudinal study of a population-based RA cohort including all prevalent RA cases in British Columbia between 1996 and 2006 and followed until 2010, with matched general population comparators. Using administrative data, we measured compliance with general population guidelines [i.e., testing plasma glucose (PG) at least once every 3 years after age 45] after excluding individuals with previous diabetes. Followup was divided into 3-year eligibility periods. Compliance was measured as the proportion of periods with ≥ 1 PG test performed. OR (95% CI) of compliance in RA (vs general population) was calculated using generalized estimating equation models, adjusting for age and sex. Mean compliance rate per patient was also calculated and compared using the Mann-Whitney U test.Results.Analysis included 22,624 individuals with RA, contributing 48,724 three-year eligibility periods; and 22,579 people in a general population group, contributing 51,081 three-year eligibility periods. PG was measured in 72.3% (SD 37%) of the eligible time periods in the RA sample and in 70.4% (SD 38%) for the general population (OR 1.05, 95% CI 1.02–1.09, p < 0.0001). RA individuals met recommended screening guidelines in 71.4% of their eligible periods, compared to 70.6% (p < 0.001). Screening improved over time in RA relative to the general population. Family physicians ordered nearly all the PG tests.Conclusion.Compliance with general population guidelines for diabetes screening in RA was suboptimal, with little difference relative to the general population, despite a higher risk of CVD and diabetes.
Preconceptional Cardiovascular Health and Pregnancy Outcomes in Women with Systemic Lupus Erythematosus
Authors: Eudy Amanda M. , Siega-Riz Anna Maria , Engel Stephanie M. , Franceschini Nora , Howard Annie Green , Clowse Megan E.B. , Petri Michelle 
Published: July 2018

Objective.To estimate the effects of preconceptional cardiovascular (CV) health, measured by American Heart Association (AHA) guidelines, on pregnancy outcomes in women with systemic lupus erythematosus (SLE).Methods.The study included patients in the Hopkins Lupus Pregnancy Cohort. Body mass index (BMI), total cholesterol, and blood pressure (BP) in the most recent clinic visit prior to conception or first trimester were used to determine CV health (ideal, intermediate, or poor health) based on AHA definitions. Outcomes included preterm birth, gestational age at birth, and small for gestational age (SGA). Multivariable linear and logistic regression models with generalized estimating equations estimated the association of each CV health factor and outcome.Results.The analysis included 309 live births. There were 95 preterm births (31%), and of the 293 pregnancies with birth weights, 18% were SGA. Ideal BMI, total cholesterol, and BP were reported in 56%, 85%, and 51% of pregnancies, respectively. Intermediate BMI was associated with decreased odds of SGA (OR 0.26, 95% CI 0.11–0.63), adjusted for race and prednisone use. Intermediate/poor total cholesterol was associated with increased odds of preterm birth (OR 2.21, 95% CI 1.06–4.62). Intermediate/poor BP was associated with decreased gestational age at birth (β −0.96, 95% CI −1.62 to −0.29).Conclusion.Poor/intermediate preconception CV health affects pregnancy outcomes of preterm birth and SGA infants among women with SLE. Efforts to maintain BMI, total cholesterol, and BP within the recommended ideal range prior to pregnancy is important to improve pregnancy outcomes in women with SLE.
Risk Factors for Future Scleroderma Renal Crisis at Systemic Sclerosis Diagnosis
Authors: Gordon Sarah M. , Stitt Rodger S. , Nee Robert , Bailey Wayne T. , Little Dustin J. , Knight Kendral R. , Hughes James B. , Edison Jess D. , Olson Stephen W. 
Published: July 2018

Objective.Systemic sclerosis (SSc) is a disease of autoimmunity, fibrosis, and vasculopathy. Scleroderma renal crisis (SRC) is one of the most severe complications. Corticosteroid exposure, presence of anti-RNA polymerase III antibodies (ARA), skin thickness, and significant tendon friction rubs are among the known risk factors at SSc diagnosis for developing future SRC. Identification of additional clinical characteristics and laboratory findings could expand and improve the risk profile for future SRC at SSc diagnosis.Methods.In this retrospective cohort study of the entire military electronic medical record between 2005 and 2016, we compared the demographics, clinical characteristics, and laboratory results at SSc diagnosis for 31 cases who developed SRC after SSc diagnosis to 322 SSc without SRC disease controls.Results.After adjustment for potential confounding variables, at SSc diagnosis these conditions were all associated with future SRC: proteinuria (p < 0.001; OR 183, 95% CI 19.1–1750), anemia (p = 0.001; OR 9.9, 95% CI 2.7–36.2), hypertension (p < 0.001; OR 13.1, 95% CI 4.7–36.6), chronic kidney disease (p = 0.008; OR 20.7, 95% CI 2.2–190.7), elevated erythrocyte sedimentation rate (p < 0.001; OR 14.3, 95% CI 4.8–43.0), thrombocytopenia (p = 0.03; OR 7.0, 95% CI 1.2–42.7), hypothyroidism (p = 0.01; OR 2.8, 95% CI 1.2–6.7), Anti-Ro antibody seropositivity (p = 0.003; OR 3.9, 95% CI 1.6–9.8), and ARA (p = 0.02; OR 4.1, 95% CI 1.2–13.8). Three or more of these risk factors present at SSc diagnosis was sensitive (77%) and highly specific (97%) for future SRC. No SSc without SRC disease controls had ≥ 4 risk factors.Conclusion.In this SSc cohort, we present a panel of risk factors for future SRC. These patients may benefit from close observation of blood pressure, proteinuria, and estimated glomerular filtration rate, for earlier SRC identification and intervention. Future prospective therapeutic studies could focus specifically on this high-risk population.
Whole Exome Sequencing in Early-onset Systemic Lupus Erythematosus
Authors: Batu Ezgi Deniz , Koşukcu Can , Taşkıran Ekim , Sahin Sezgin , Akman Sema , Sözeri Betül , Ünsal Erbil , Bilginer Yelda , Kasapcopur Ozgur , Alikaşifoğlu Mehmet , Ozen Seza 
Published: July 2018

Objective.Systemic lupus erythematosus (SLE) is a multisystem autoimmune disorder. Early-onset, familial, and/or syndromic SLE may reveal monogenic pathologies. The aim of this study was to examine genetic associations in patients with early-onset or familial SLE.Methods.We enrolled 7 SLE cases (from different families) with disease onset ≤ 5 years of age and family history consistent with an autosomal recessive inheritance. Whole exome sequencing (WES) was performed in 6 index cases. Suspected variants were confirmed by Sanger sequencing. We did not perform WES in 1 patient who had features similar to the first 3 cases; only the exons ofC1QA, C1QB,andC1QCwere screened with Sanger sequencing.Results.We demonstrated 2 novel and 3 previously reported variants in genes associated with SLE: a homozygous non-sense alteration (c.622C>T/p.Gln208Ter) inC1QAin 2 patients; homozygous non-sense alteration (c.79C>T/p.Gln27Ter) inC1QCin 1 (novel variant); homozygous missense alteration (c.100G>A/p.Gly34Arg) inC1QCin 1; homozygous missense alteration (c.1945G>C/p.Ala649Pro) inC1Sin 1 (novel variant); and homozygous frameshift alteration (c.289_290delAC/p.Thr97Ilefs*2) inDNASE1L3in 1 patient. Further, in 1 patient, we determined a strong candidate variant inHDAC7(histone decetylase 7).Conclusion.Five patients had homozygous alterations in genes coding early complement proteins. This may lead to decreased clearance of apoptotic bodies. One patient hadDNASE1L3variant, which functions in the clearance of self-antigens. In 1 patient, we determined a novel gene that may be important in SLE pathogenesis. We suggest that monogenic causes/associations should be sought in early-onset and/or familial SLE.
Clinical and Laboratory Characteristics and Mortality in Korean Patients with Systemic Sclerosis: A Nationwide Multicenter Retrospective Cohort Study
Authors: Moon Ki Won , Lee Shin-Seok , Lee Yun Jong , Jun Jae-Bum , Yoo Su-Jin , Ju Ji Hyeon , Chang Sung Hae , Choi In Ah , Kang Tae Young , Lee Eun Bong , Lee Seung-Geun 
Published: July 2018

Objective.We aimed to investigate demographic and clinical features and predictors of mortality in Korean patients with systemic sclerosis (SSc).Methods.We performed a retrospective multicenter medical chart review in Korean patients diagnosed with SSc from 1986 to 2016 at 11 university hospitals representing each geographic area of Korea. SSc patients were defined according to the American College of Rheumatology preliminary classification criteria and subtyped as limited cutaneous (lcSSc) or diffuse cutaneous (dcSSc) SSc.Results.We enrolled 751 patients (female, 86.7%; mean age at diagnosis, 48.9 yrs). The most common organ involvement was interstitial lung disease (52.7%), followed by gastroesophageal reflux disease (32.9%) and pulmonary arterial hypertension (13.6%). Patients with lcSSc were more common than those with dcSSc (64.8 vs 35.2%), whereas anti-Scl-70 and anticentromere antibody positivity were identified in 302 (42.5%) and 175 (25.5%) patients, respectively. In the 46 (6.1%) patients who developed a malignancy, lung cancer (23.9%) was the most common diagnosis, followed by gastric (13%) and breast cancer (13%). During the study period, 57 (7.6%) patients died, and the 5- and 10-year survival rates were 94% and 87%, respectively. Increased age at diagnosis, cardiovascular involvement, and anti-Scl-70 antibody positivity were significant predictors of death.Conclusion.Clinical manifestations and survival rates in Korean SSc patients are similar to those of other populations. However, the prevalence of anti-Scl-70 antibody is higher in Korean SSc patients compared with whites, while the prevalence of anticentromere antibody is lower.
Primary and Secondary Fibromyalgia Are The Same: The Universality of Polysymptomatic Distress
Authors: Wolfe Frederick , Walitt Brian , Rasker Johannes J. , Häuser Winfried 
Published: July 2018

Objective.Polysymptomatic distress (PSD) is the underlying metric of fibromyalgia (FM), and levels of PSD can identify criteria-positive FM with > 90% accuracy. We used levels of the PSD scale to test whether symptom levels in primary FM (PFM) and secondary FM (SFM) were the same and whether symptoms were equivalent in persons not meeting FM criteria.Methods.We studied 1525 patients with a clinical diagnosis of FM and 12,037 patients with rheumatoid arthritis (RA). We used regression models to compare patients with potential and actual PFM to RA patients with potential and actual SFM for 17 key clinical variables.Results.When controlled for PSD values, the widespread pain index, symptom severity scale, and pain, global, quality of life, and physical and mental component scores were essentially the same or only slightly different in PFM and SFM. Health Assessment Questionnaire-Disability Index scores were slightly higher in SFM (0.21 units), as was the painful joint count (1.6 joints). Overall, higher PSD scores were associated with more severe symptoms or abnormal status. PSD scores in patients not satisfying FM criteria and in patients satisfying criteria operated similarly.Conclusion.PFM and SFM are equivalent regarding symptom burden. PSD scores are more informative about severity and severity within diagnosis than dichotomization into FM/non-FM. Studies of FM versus “healthy individuals,” or FM versus other diseases, are inherently defective, while studies of FM and PSD in RA offer the opportunity to have meaningful comparison groups, because there are no readily available unbiased appropriate controls for PFM.
Tongue Atrophy in Sjögren Syndrome Patients with Mucosa-associated Lymphoid Tissue Lymphoma: Autoimmune Epithelitis beyond the Epithelial Cells of Salivary Glands?
Authors: Zampeli Evangelia , Kalogirou Eleni-Marina , Piperi Evangelia , Mavragani Clio P. , Moutsopoulos Haralampos M. 
Published: July 2018

Objective.Primary Sjögren syndrome (pSS), an autoimmune epithelitis, bears the risk of evolving to non-Hodgkin lymphoma and most frequently to the mucosa-associated lymphoid tissue (MALT) subtype. Based on the observation that pSS patients with MALT present a more atrophic and more intensely fissured tongue, we aimed to semiquantify severity of tongue atrophy and clinically assess lingual appearance in pSS patients with and without MALT, and investigate whether tongue atrophy and fissured appearance could serve as clinical indicators/signs of MALT.Methods.A blinded complete oral examination was performed in pSS patients with and without MALT. Tongue atrophy was scored using a semiquantified atrophy score. Clinical and laboratory variables were recorded for all patients.Results.After excluding pSS patients with oral candidiasis, iron deficiency, and megaloblastic anemia, 19 pSS patients with salivary MALT were matched 1:3 for age, sex, and disease duration with 57 pSS patients without MALT. The pSS-MALT patients had increased prevalence of salivary gland enlargement, lymphadenopathy, monoclonal gammopathy, rheumatoid factor positivity, higher focus and Tarpley scores in the minor salivary gland biopsy, and hyposalivation, compared to the pSS non-MALT patients. A significantly higher prevalence of tongue atrophy (68% vs 30%, p = 0.006) and fissured tongue (89% vs 33%, p < 0.001) was observed in the former group. Multivariate analysis showed that fissured tongue appearance, hyposalivation, and lymphadenopathy associate independently with salivary MALT in pSS.Conclusion.These results suggest that pSS patients with lymphoid malignancy exhibit a more atrophic and more fissured tongue. This particular clinical tongue appearance can serve as an additional clinical sign for salivary MALT lymphoma in pSS patients.
Les premiers échos du pronunciamiento de 1820 dans la presse parisienne
Authors: Nagy Laurent 
Published: July 2018

Qualifié de « révolte prétorienne » par les uns ou de « soulèvement national » par les autres, le mouvement militaire de Las Cabezas de San Juan du 1er janvier 1820 se colore en France de la teinte politique des différents journaux d’opinion. Avec une promptitude extraordinaire, à un moment de très grande conflictualité politique, les publicistes imposent les affaires d’Espagne dans les débats français.Cet article, limité dans le temps aux trois mois d’incertitude concernant l’issue de l’insurrection et confiné à l’espace de la presse quotidienne parisienne, vise avant tout à revenir sur la perception immédiate d’un événement transnational. Il s’arrête aussi sur la manière dont certains titres, au détriment de la réalité des faits, s’approprient les péripéties survenues en Andalousie pour mieux agir sur l’opinion publique française.
Geographic Trends in the Orthopedic Surgery Residency Match
Authors: Cox Ryan M. , Sobel Andrew D. , Biercevicz Alison , Eberson Craig P. , Mulcahey Mary K. 
Published: July 2018

ABSTRACT

Background
Residency program location may be an important factor for orthopedic surgery residency applicants. More than half of residents locate their practice near the site of their training, and surgical specialties (eg, otolaryngology, plastic surgery, and general surgery) have shown geographic patterns in their residency matches.

Objective
We analyzed geographic trends in the orthopedic surgery Match.

Methods
Hometown, undergraduate institution, and medical school “preresidency locations” of all allopathic, nonmilitary, orthopedic surgery residents were recorded from program websites for the 2015–2016 academic year. Program and preresidency locations were coded according to state and US census division. Statistical analysis was used to investigate associations between residency program locations and preresidency locations.

Results
Of 2662 residents in the study, 1220 of 2614 (47%), 536 of 1329 (40%), and 308 of 744 (41%) matched into the same division as their medical school, undergraduate institution, and hometown, respectively. There were significant differences among divisions (P &lt; .001). Also, 817 of 2662 (31%), 319 of 1329 (24%), and 200 of 770 (26%) residents matched in the same state as their medical school, undergraduate institution, and hometown, respectively, with significant differences between states for medical school (P &lt; .0001) and undergraduate institution (P &lt; .0001), but not hometown (P = .22). Overall, 21% of residents (538 of 2612) matched at the program affiliated with their medical school.

Conclusions
There is an association among hometown, undergraduate institution, and medical school for the training program location in which orthopedic surgery residents match, with variability in locations matched at state and census division levels.
Quantification of peroxynitric acid and peroxyacyl nitrates using an ethane-based thermal dissociation peroxy radical chemical amplification cavity ring-down spectrometer
Authors: Taha Youssef M. , Saowapon Matthew T. , Assad Faisal V. , Ye Connie Z. , Chen Xining , Garner Natasha M. , Osthoff Hans D. 
Published: July 2018

Abstract. Peroxy and peroxyacyl nitrates (PNs and PANs) are important trace gas constituents of the troposphere which are challenging to quantify by differential thermal dissociation with NO2 detection in polluted (i.e., high-NOx) environments. In this paper, a thermal dissociation peroxy radical chemical amplification cavity ring-down spectrometer (TD-PERCA-CRDS) for sensitive and selective quantification of total peroxynitrates (ΣPN  =  ΣRO2NO2) and of total peroxyacyl nitrates (ΣPAN  =  ΣRC(O)O2NO2) is described. The instrument features multiple detection channels to monitor the NO2 background and the ROx ( =  HO2 + RO2 + ΣRO2) radicals generated by TD of ΣPN and/or ΣPAN. Chemical amplification is achieved through the addition of 0.6 ppm NO and 1.6 % C2H6 to the inlet. The instrument's performance was evaluated using peroxynitric acid (PNA) and peroxyacetic or peroxypropionic nitric anhydride (PAN or PPN) as representative examples of ΣPN and ΣPAN, respectively, whose abundances were verified by iodide chemical ionization mass spectrometry (CIMS). The amplification factor or chain length increases with temperature up to 69 ± 5 and decreases with analyte concentration and relative humidity (RH). At inlet temperatures above 120 and 250 °C, respectively, PNA and ΣPAN fully dissociated, though their TD profiles partially overlap. Furthermore, interference from ozone (O3) was observed at temperatures above 150 °C, rationalized by its partial dissociation to O atoms which react with C2H6 to form C2H5 and OH radicals. Quantification of PNA and ΣPAN in laboratory-generated mixtures containing O3 was achieved by simultaneously monitoring the TD-PERCA responses in multiple parallel CRDS channels set to different temperatures in the 60 to 130 °C range. The (1 s, 2σ) limit of detection (LOD) of TD-PERCA-CRDS is 6.8 pptv for PNA and 2.6 pptv for ΣPAN and significantly lower than TD-CRDS without chemical amplification. The feasibility of TD-PERCA-CRDS for ambient air measurements is discussed.
Effect of essential oils of Lamiaceae plants on the Rhizopus spp.
Authors: Tančinová Dana , Mašková Zuzana , Denisa Foltinová Denisa , Štefániková Jana , Árvay Július 
Published: July 2018

The aim of this study was to evaluate the fungicidal effect of eleven essential oils against six isolates of the genus Rhizopus. Isolates were obtained from various moldy foods (chestnut, bread, strawberry, nectarine, blackberry and cherry tomatoes). The essential oils used in this study were extracts of basil (Oscimum basilicum L.), hyssop (Hyssopus officinalis L.), lavender (Lavandula angustifolia MILLER.), marjoram (Origanum majorana L.), mint (Mentha piperita L.), oregano (Origanum vulgare L.), rosemary (Rosmarinus officinalis L.), sage (Salvia officinalis L.), summer savory (Satureja hortensis L.), thyme (Thymus vulgaris L.) and wild thyme (Thymus serpyllum L.). Semi-quantitative composition of the essential oil samples was determined by gas chromatography coupled with mass spectrometry (GC-MS). The GC-MS analyses of the essential oils led to identification of 139 compounds, of which 49 were presented in ≥1% amount in at least one essential oil. The antifungal activity of essential oils against the Rhizopus spp. was determined, using micro-atmosphere method (0.625 μL.ml-1 of air), during 7 days. Seven essential oils: thyme, mint, summer savory, lavender, marjoram, oregano and wild thyme completely inhibited the growth of all isolates. Other essential oils have different effects on the growth of isolates. Basil essential oil stimulated growth of two isolates on the second day of cultivation. The growth of other isolates was, by contrast, inhibited by this essential oil in the same time of cultivation. Hyssop essential oil completely inhibited growth of two isolates, other 4 isolates were inhibited to fourth day of cultivation. In conclusion, certain essential oils are highly effective in vapour phase and can be used in another test of their antifungal activity and could be used in control of Rhizopus spp. or other fungal pathogens.