bluuebunny/crossref_metadata_2025_split huggingface dataset:
Historical state stability and economic development in Europe
Authors: Harish S.P. , Paik Christopher 
Published: July 2019

AbstractIn this paper, we show that state stability exhibits a persistent and robust non-monotonic relationship with economic development. Based on observations in Europe spanning from 1 to 2000 AD, regions that have historically experienced either short- or long-duration state rule on average lag behind in their local wealth today, while those that have experienced medium-duration state rule fare better. These findings support the argument that both an absence as well as an excess of state stability are bad for economic development. State instability hinders investment for growth, while too much stability is likely indicative of elite capture and subsequent stagnation of innovation.
Associations between negative life experiences and the mental health of trans and gender diverse young people in Australia: findings from Trans Pathways
Authors: Strauss Penelope , Cook Angus , Winter Sam , Watson Vanessa , Wright Toussaint Dani , Lin Ashleigh 
Published: July 2019

AbstractBackgroundTrans and gender diverse (TGD) young people worldwide experience high rates of poor mental health; however, these rates were unknown in Australia. In addition, how negative life events affect the mental health of TGD young people has been largely unexplored.MethodsThis paper reports on novel mental health findings of Trans Pathways, the largest study ever conducted in Australia with trans (transgender) and gender diverse young people (N = 859; aged 14–25 years). The study was an anonymous online cross-sectional survey undertaken in 2016. Logistic and linear regression models were used to test associations between mental health outcomes and negative life experiences.ResultsTGD young people in Australia experience high levels of mental distress, including self-harming (79.7%), suicidal thoughts (82.4%), and attempting suicide (48.1%). Three in four participants had been diagnosed with depression and/or anxiety (74.6% and 72.2%, respectively). Many TGD young people had been exposed to negative experiences such as peer rejection (89.0%), precarious accommodation (22.0%), bullying (74.0%), and discrimination (68.9%). Most poor mental health outcomes were associated with negative experiences. The strongest associations were found for precarious accommodation and issues within educational settings. For example, participants with a prior suicide attempt were almost six times more likely to have experienced issues with accommodation, including homelessness.ConclusionsThe current results highlight the urgent need for better mental health care and provide insight into areas for targeted mental health interventions. These findings are pertinent for clinicians working with trans young people and wider society.
Is motivated submaximization good enough for God?
Authors: KRAAY KLAAS J. 
Published: July 2019

AbstractIn a recent article (Kraay 2013), I argued that some prominent responses to two important arguments for atheism invokedivine satisficing– and that the coherence and propriety of this notion have not been established. Chris Tucker (2016) agrees with my evaluation of divine satisficing, but disagrees with my exegesis of these responses. He argues that they should be understood as invokingmotivated submaximizationinstead. After reviewing the dialectical situation to date, I assess whether motivated submaximization can be deployed in such a way as to defeat these arguments for atheism. I argue that it's far from clear that it can.
Do Deltas Along the Crustal Dichotomy Boundary of Mars in the Gale Crater Region Record a Northern Ocean?
Authors: Rivera‐Hernández Frances , Palucis Marisa C. 
Published: July 2019

AbstractDeltaic deposits mapped along the Martian crustal dichotomy boundary scarp have been suggested to delineate an ancient ocean in the northern lowlands of Mars. Using recently acquired orbital data, we have expanded the dichotomy delta inventory and performed an updated analysis of delta front elevations, a proxy for paleo‐water levels. Our analysis focused near Gale crater, home of the Curiosity rover. We found that delta front elevations vary by approximately 2,400 m, but these elevation variations do not correspond to modeled deformation from true polar wander or Tharsis. Locally, delta front elevations vary by ≤60 m, and using present‐day topography, they correspond to distinct enclosed basins. We infer that these deltas formed in paleo‐lakes up to approximately 13,000 km2 and approximately 0.4 km deep, perhaps coeval with paleo‐lakes in Gale. Our results suggest that a northern ocean is not needed to explain the deltaic deposits in the Gale crater region.
Ionospheric Cold Ions Detected by MMS Behind Dipolarization Fronts
Authors: Xu Y. , Fu H. S. , Norgren C. , Toledo‐Redondo S. , Liu C. M. , Dong X. C. 
Published: July 2019

AbstractTraditionally, dipolarization front (DF) is a discontinuity at the leading edge of the high‐speed plasma jets, separating hot tenuous plasma from the denser ambient plasma. The particles behind the DF are usually hot population resulting from various heating and acceleration processes therein. Here, using Magnetospheric Multiscale (MMS) observations, we report that cold ions of ionospheric origin can be found behind the DFs. These cold ions move along the reconnected magnetic field lines directly from lobe during substorm, forming counter‐streaming cold ion flows behind the DFs. We find that cold ionospheric ions, as an additional population behind the DF, could increase ion density by ~50%. This indicates that the cold ions can change the gradients in the plasma density, such as the density‐driven instabilities near the DFs, and further affect the DF dynamics.
The SRCIN1/p140Cap adaptor protein negatively regulates the aggressiveness of neuroblastoma
Authors: Grasso Silvia , Cangelosi Davide , Chapelle Jennifer , Alzona Melissa , Centonze Giorgia , Lamolinara Alessia , Salemme Vincenzo , Angelini Costanza , Morellato Alessandro , Saglietto Andrea , Bianchi Federico Tommaso , Cabodi Sara , Salaroglio Iris Chiara , Fusella Federica , Ognibene Marzia , Iezzi Manuela , Pezzolo Annalisa , Poli Valeria , Di Cunto Ferdinando , Eva Alessandra , Riganti Chiara , Varesio Luigi , Turco Emilia , Defilippi Paola 
Published: July 2019

AbstractNeuroblastoma is the most common extra-cranial pediatric solid tumor, responsible for 13–15% of pediatric cancer death. Its intrinsic heterogeneity makes it difficult to target for successful therapy. The adaptor protein p140Cap/SRCIN1 negatively regulates tumor cell features and limits breast cancer progression. This study wish to assess if p140Cap is a key biological determinant of neuroblastoma outcome. RNAseq profiles of a large cohort of neuroblastoma patients show that SRCIN1 mRNA levels are an independent risk factor inversely correlated to disease aggressiveness. In high-risk patients, CGH+SNP microarray analysis of primary neuroblastoma identifies SRCIN1 as frequently altered by hemizygous deletion, copy-neutral loss of heterozygosity, or disruption. Functional experiments show that p140Cap negatively regulates Src and STAT3 signaling, affects anchorage-independent growth and migration, in vivo tumor growth and spontaneous lung metastasis formation. p140Cap also increases sensitivity of neuroblastoma cells to doxorubicin and etoposide treatment, as well as to a combined treatment with chemotherapy drugs and Src inhibitors. Our functional findings point to a causal role of p140Cap in curbing the aggressiveness of neuroblastoma, due to its ability to impinge on specific molecular pathways, and to sensitize cells to therapeutic treatment. This study provides the first evidence that the SRCIN1/p140Cap adaptor protein is a key player in neuroblastoma as a new independent prognostic marker for patient outcome and treatment. Altogether, these data highlight the potential clinical impact of SRCIN1/p140Cap expression in neuroblastoma tumors, in terms of reducing cytotoxic effects of chemotherapy, one of the main issues for pediatric tumor treatment.
PGRN acts as a novel regulator of mitochondrial homeostasis by facilitating mitophagy and mitochondrial biogenesis to prevent podocyte injury in diabetic nephropathy
Authors: Zhou Di , Zhou Meng , Wang Ziying , Fu Yi , Jia Meng , Wang Xiaojie , Liu Min , Zhang Yan , Sun Yu , Lu Yi , Tang Wei , Yi Fan 
Published: July 2019

AbstractMitochondrial dysfunction is considered as a key mediator in the pathogenesis of diabetic nephropathy (DN). Therapeutic strategies targeting mitochondrial dysfunction hold considerable promise for the treatment of DN. In this study, we investigated the role of progranulin (PGRN), a secreted glycoprotein, in mediating mitochondrial homeostasis and its therapeutic potential in DN. We found that the level of PGRN was significantly reduced in the kidney from STZ-induced diabetic mice and patients with biopsy-proven DN compared with healthy controls. In DN model, PGRN-deficient mice aggravated podocyte injury and proteinuria versus wild-type mice. Functionally, PGRN deficiency exacerbated mitochondrial damage and dysfunction in podocytes from diabetic mice. In vitro, treatment with recombinant human PGRN (rPGRN) attenuated high glucose-induced mitochondrial dysfunction in podocytes accompanied by enhanced mitochondrial biogenesis and mitophagy. Inhibition of mitophagy disturbed the protective effects of PGRN in high glucose-induced podocytotoxicity. Mechanistically, we demonstrated that PGRN maintained mitochondrial homeostasis via PGRN-Sirt1-PGC-1α/FoxO1 signaling-mediated mitochondrial biogenesis and mitophagy. Finally, we provided direct evidence for therapeutic potential of PGRN in mice with DN. This study provides new insights into the novel role of PGRN in maintaining mitochondrial homeostasis, suggesting that PGRN may be an innovative therapeutic strategy for treating patients with DN.
Avenanthramide-C prevents noise- and drug-induced hearing loss while protecting auditory hair cells from oxidative stress
Authors: Umugire Alphonse , Lee Sungsu , Kim Dami , Choi Munyoung , Kim Hyung-Seok , Cho Hyong-Ho 
Published: July 2019

AbstractNoise exposure or ototoxic drugs instigate various types of damage to the cochlea, resulting in hearing loss (HL). While the incidence of HL is growing continuously, there are, so far, no adequate drugs to prevent or treat HL. Avenanthramide (AVN), a natural product extracted from oats, has been reported to possess anti-oxidant/inflammatory properties, and protect several types of cells. In this study, we investigated whether AVN-C can protect auditory hair cells, and preserve hearing from noise trauma and ototoxic drugs. Wild-type C57BL/6 mice were used to generate several HL models. Serum and perilymphatic fluid samples were analyzed using mass spectrophotometry to detect AVN-C. AVN-C crossed the blood-labyrinth barrier, and was detected in the perilymph after systemic injection. Pretreatment by AVN-C 24 h before exposure to temporary threshold shift noise contributed to the preserving hearing. Moreover, in the case of permanent threshold shift, AVN-C provided significant protection from noise. AVN-C also strongly protected against deterioration in hearing due to kanamycin and furosemide (K + F). According to the results of our scanning electron microscopy analysis, many outer hair cells (OHCs) were destroyed by noise trauma, while AVN-C prevented these losses. OHC loss due to K + F was even more severe, even affecting the apex. Strikingly, AVN-C treatment maintained OHCs at a level comparable to normal cochlea. AVN-C reduced the dichlorofluorescin (DCF)-positive population in gentamicin-treated HEI-OC1 in vitro. The expressions of TNF-a, BAK, IL-1b, and Bcl-2 were attenuated by AVN-C, revealing its antioxidant effects. The results of this study show that AVN-C crosses the blood-labyrinth barrier and provide a significant protection against noise- and drug-induced ototoxicity. Hence, AVN-C is a good candidate for future therapy aimed at protecting against sensorineural HL.
The cryo-electron microscopy supramolecular structure of the bacterial stressosome unveils its mechanism of activation
Authors: Williams Allison H. , Redzej Adam , Rolhion Nathalie , Costa Tiago R. D. , Rifflet Aline , Waksman Gabriel , Cossart Pascale 
Published: July 2019

AbstractHow the stressosome, the epicenter of the stress response in bacteria, transmits stress signals from the environment has remained elusive. The stressosome consists of multiple copies of three proteins RsbR, RsbS and RsbT, a kinase that is important for its activation. Using cryo-electron microscopy, we determined the atomic organization of theListeria monocytogenesstressosome at 3.38 Å resolution. RsbR and RsbS are organized in a 60-protomers truncated icosahedron. A key phosphorylation site on RsbR (T209) is partially hidden by an RsbR flexible loop, whose “open” or “closed” position could modulate stressosome activity. Interaction between three glutamic acids in the N-terminal domain of RsbR and the membrane-bound mini-protein Prli42 is essential forListeriasurvival to stress. Together, our data provide the atomic model of the stressosome core and highlight a loop important for stressosome activation, paving the way towards elucidating the mechanism of signal transduction by the stressosome in bacteria.
FLOTROP, a massive contribution to plant diversity data for open ecosystems in northern tropical Africa
Authors: Taugourdeau Simon , Daget Philippe , Chatelain Cyrille , Mathieu Daniel , Juanes Xavier , Huguenin Johann , Ickowicz Alexandre 
Published: July 2019

AbstractThe FLOTROP dataset contains numerous plant observations (around 340,000 occurrences) in northern tropical Africa (from the 5th to 25th parallel north) in open ecosystems (savannah and steppe). They were collected by multiple collectors between 1920 and 2012 and were managed by Philippe Daget. These observations are probably the most important and unique source of plant distribution over the Sahel area. The data are now available in the Global Biodiversity Information Facility, Tela Botanica website, and as maps in the African Plant Database. For the overall area involved, this dataset has increased by 40% the data available in the GBIF. For some countries between the 15th and 21st parallel north, the FLOTROP dataset has increased available occurrences 10-fold compared to the data existing in the GBIF.
Radiation emission in laser-wakefields driven by structured laser pulses with orbital angular momentum
Authors: Luís Martins Joana , Vieira Jorge , Ferri Julien , Fülöp Tünde 
Published: July 2019

AbstractHigh-intensity X-ray sources are invaluable tools, enabling experiments at the forefront of our understanding of materials science, chemistry, biology, and physics. Laser-plasma electron accelerators are sources of high-intensity X-rays, as electrons accelerated in wakefields emit short-wavelength radiation due to betatron oscillations. While applications such as phasecontrast imaging with these betatron sources have already been demonstrated, others would require higher photon number and would benefit from increased tunability. In this paper we demonstrate, through detailed 3D simulations, a novel configuration for a laser-wakefield betatron source that increases the energy of the X-ray emission and also provides increased flexibility in the tuning of the X-ray photon energy. This is made by combining two Laguerre-Gaussian pulses with non-zero net orbital angular momentum, leading to a rotation of the intensity pattern, and hence, of the driven wakefields. The helical motion driven by the laser rotation is found to dominate the radiation emission, rather than the betatron oscillations. Moreover, the radius of this helical motion can be controlled through the laser spot size and orbital angular momentum indexes, meaning that the radiation can be tuned fully independently of the plasma parameters.
Spectral changes associated with transmission of OLED emission through human skin
Authors: Yambem Soniya D. , Brooks-Richards Trent L. , Forrestal David P. , Kielar Marcin , Sah Pankaj , Pandey Ajay K. , Woodruff Maria A. 
Published: July 2019

AbstractA recent and emerging application of organic light emitting diodes (OLEDs) is in wearable technologies as they are flexible, stretchable and have uniform illumination over a large area. In such applications, transmission of OLED emission through skin is an important part and therefore, understanding spectral changes associated with transmission of OLED emission through human skin is crucial. Here, we report results on transmission of OLED emission through human skin samples for yellow and red emitting OLEDs. We found that the intensity of transmitted light varies depending on the site from where the skin samples are taken. Additionally, we show that the amount of transmitted light reduces by ~ 35–40% when edge emissions from the OLEDs are blocked by a mask exposing only the light emitting area of the OLED. Further, the emission/electroluminescence spectra of the OLEDs widen significantly upon passing through skin and the full width at half maximum increases by >20 nm and >15 nm for yellow and red OLEDs, respectively. For comparison, emission profile and intensities of transmitted light for yellow and red inorganic LEDs are also presented. Our results are highly relevant for the rapidly expanding area of non-invasive wearable technologies that use organic optoelectronic devices for sensing.
An Innovative Platform Merging Elemental Analysis and Ftir Imaging for Breast Tissue Analysis
Authors: Ali Mohamed H. M. , Rakib Fazle , Al-Saad Khalid , Al-Saady Rafif , Goormaghtigh Erik 
Published: July 2019

AbstractHistopathology and immunohistology remain the gold standard for breast cancer diagnostic. Yet, these approaches do not usually provide a sufficiently detailed characterization of the pathology. The purpose of this work is to demonstrate for the first time that elemental analysis and Fourier transform infrared spectroscopy microscopic examination of breast tissue sections can be merged into one dataset to provide a single set of markers based on both organic molecules and inorganic trace elements. For illustrating the method, 6 mammary tissue sections were used. Fourier transform infrared (FTIR) spectroscopy images reported a fingerprint of the organic molecules present in the tissue section and laser ablation elemental analysis (LA-ICP-MS) images brought inorganic element profiles. The 6 tissue sections provided 31 106 and 150,000 spectra for FTIR and LA-ICP-MS spectra respectively. The results bring the proof of concept that breast tissue can be analyzed simultaneously by FTIR spectroscopy and laser ablation elemental analysis (LA-ICP-MS) to provide in both case reasonably high resolution images. We show how to bring the images obtained by the two methods to a same spatial resolution and how to use image registration to analyze the data originating from both techniques as one block of data. We finally demonstrates the elemental analysis is orthogonal to all FTIR markers as no significant correlation is found between FTIR and LA-ICP-MS data. Combining FTIR and LA-ICP-MS imaging becomes possible, providing two orthogonal methods which can bring an unprecedented diversity of information on the tissue. This opens a new avenue of tissue section analyses providing unprecedented diagnostic potential.
Improving species distribution models of zoonotic marine parasites
Authors: Alt Katharina G. , Kochmann Judith , Klimpel Sven , Cunze Sarah 
Published: July 2019

AbstractEnvironmental niche modelling is an acclaimed method for estimating species’ present or future distributions. However, in marine environments the assembly of representative data from reliable and unbiased occurrences is challenging. Here, we aimed to model the environmental niche and distribution of marine, parasitic nematodes from the Pseudoterranova decipiens complex using the software Maxent. The distribution of these potentially zoonotic species is of interest, because they infect the muscle tissue of host species targeted by fisheries. To achieve the best possible model, we used two different approaches. The land distance (LD) model was based on abiotic data, whereas the definitive host distance (DHD) model included species-specific biotic data. To assess whether DHD is a suitable descriptor for Pseudoterranova spp., the niches of the parasites and their respective definitive hosts were analysed using ecospat. The performance of LD and DHD was compared based on the variables’ contribution to the model. The DHD-model clearly outperformed the LD-model. While the LD-model gave an estimate of the parasites’ niches, it only showed the potential distribution. The DHD-model produced an estimate of the species’ realised distribution and indicated that biotic variables can help to improve the modelling of data-poor, marine species.
The AMPK system of salmonid fishes was expanded through genome duplication and is regulated by growth and immune status in muscle
Authors: Causey Dwight R. , Kim Jin-Hyoung , Devlin Robert H. , Martin Samuel A. M. , Macqueen Daniel J. 
Published: July 2019

Abstract5′adenosine monophosphate-activated protein kinase (AMPK) is a master regulator of energy homeostasis in eukaryotes. This study identified expansions in the AMPK-α, -β and -γ families of salmonid fishes due to a history of genome duplication events, including five novel salmonid-specific AMPK subunit gene paralogue pairs. We tested the hypothesis that the expanded AMPK gene system of salmonids is transcriptionally regulated by growth and immunological status. As a model, we studied immune-stimulated coho salmon (Oncorhynchus kisutch) from three experiment groups sharing the same genetic background, but showing highly-divergent growth rates and nutritional status. Specifically, we compared wild-type and GH-transgenic fish, the latter achieving either enhanced or wild-type growth rate via ration manipulation. Transcript levels for the fifteen unique salmonid AMPK subunit genes were quantified in skeletal muscle after stimulation with bacterial or viral mimics to alter immune status. These analyses revealed a constitutive up-regulation of several AMPK-α and -γ subunit-encoding genes in GH-transgenic fish achieving accelerated growth. Further, immune stimulation caused a decrease in the expression of several AMPK subunit-encoding genes in GH-transgenic fish specifically. The dynamic expression responses observed suggest a role for the AMPK system in balancing energetic investment into muscle growth according to immunological status in salmonid fishes.
Targeting DNAJB9, a novel ER luminal co-chaperone, to rescue ΔF508-CFTR
Authors: Huang Yunjie , Arora Kavisha , Mun Kyu Shik , Yang Fanmuyi , Moon ChangSuk , Yarlagadda Sunitha , Jegga Anil , Weaver Timothy , Naren Anjaparavanda P. 
Published: July 2019

AbstractThe molecular mechanism of Endoplasmic Reticulum-associated degradation (ERAD) of Cystic fibrosis transmembrane-conductance regulator (CFTR) is largely unknown. Particularly, it is unknown what ER luminal factor(s) are involved in ERAD. Herein, we used ProtoArray to identify an ER luminal co-chaperone, DNAJB9, which can directly interact with CFTR. For both WT- and ΔF508 (deletion of phenylalanine at position 508, the most common CF-causing mutant)-CFTR, knockdown of DNAJB9 by siRNA increased their expression levels on the cell surface and, consequently, upregulated their function. Furthermore, genetic ablation of DNAJB9 in WT mice increased CFTR expression and enhanced CFTR-dependent fluid secretion in enteroids. Importantly, DNAJB9 deficiency upregulated enteroids’ fluid secretion in CF mice (homozygous for ΔF508), and silencing one allele of DNAJB9 is sufficient to rescue ΔF508-CFTR in vitro and in vivo, suggesting that DNAJB9 may be a rate-limiting factor in CFTR ERAD pathway. Our studies identified the first ER luminal co-chaperone involved in CFTR ERAD, and DNAJB9 could be a novel therapeutic target for CF.