bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparison of conformal radiotherapy, intensity-modulated radiotherapy and tomotherapy irradiation techniques in prostate cancers
Authors: Tuğrul Taylan , Olacak Nezahat , Köylü Murat 
Published: February 2019

AbstractAimThe aim of this study is to compare three-dimensional conformal radiotherapy (3D-CRT), intensity-modulated radiotherapy (IMRT) and tomotherapy techniques used in the treatment of prostate cancer with target and critical organ doses to be included.Materials and MethodsThe target dose was studied with 4-and 6-field 3D-CRT, 7-field IMRT and tomotherapy techniques used to treat ten patients for prostate cancer and the dose volume histograms of critical organs were analyzed. The same target volumes, critical organs doses prescribed and treatment times for the three techniques were compared. Total dose of 76 Gy was given using 6 MV and 18 MV for 3D-CRT, 6 MV for IMRT and tomotherapy techniques.ResultsWhen we compare the three techniques, for rectum V35(p:0·001), V65(p:0·001), D50(p:0·020) and D25(p:0·002), for bladder V50(p:0·027), V65(p:0·006), V100(p:0·006) and for femoral head, the V50(p:0·001) dose was found to be significantly different and more favourable in the tomotherapy technique. Significant differences were found with IMRT planning in 50% of bladder volume (p:0·002). There is no significant difference between the three techniques for doses of 100% volume of rectum and 25% of volume of bladder. The minimum dose that healthy tissue received which was outside the tumour volume was investigated.FindingsDoses to critical organs were lower using the tomotherapy technique. However, the minimum doses that healthy tissue received were higher for the tomotherapy technique. When the beam on times were compared for all three techniques, a significant difference was found in favor of tomotherapy.
No beneficial effects of resveratrol supplementation on atherogenic risk factors in patients with nonalcoholic fatty liver disease
Authors: Farzin L. , Asghari S. , Rafraf M. , Asghari-Jafarabadi M. , Shirmohammadi M. 
Published: February 2019

Abstract. Introduction: Cardiovascular disease (CVD) accounts as a major cause of mortality among patients with nonalcoholic fatty liver disease (NAFLD). Resveratrol, a natural polyphenol compound, is known for its antioxidant and antiatherogenic properties and is purported to be beneficial in decreasing CVD risk factors in NAFLD patients. Objectives: This study aimed to investigate the effects of resveratrol on atherogenic risk factors in patients with NAFLD. Methods: This randomized, double-blind, placebo-controlled clinical trial was performed on 50 patients with NAFLD aged 20-60 years. Subjects were randomly assigned to receive a daily dose of 600 mg resveratrol (n = 25) or placebo (n = 25) for 12 wk. Serum liver enzymes, lipid profile and atherogenic indices, blood pressure and anthropometric values were assessed pre and post-treatment. Results: Resveratrol supplementation reduced body weight (from 88.75 ± 11.41 to 87.54 ± 11.18 kg, P = 0.005) and BMI (from 31.00 ± 3.16 to 30.60 ± 3.26 kg/m², P = 0.01) significantly compared to the placebo group. A significant reduction in waist circumference was observed within resveratrol group (from 102.70 ± 7.68 to 101.39 ± 7.62 cm, P = 0.02). There were no significant changes in lipid profile (ox-LDL, ApoA1 and ApoB), serum atherogenic indices (LDL-C/HDL-C, ApoB/ApoA1, ox-LDL/ApoB, LDL-C/ox-LDL and AIP), liver enzymes (AST, ALT, ALP and GGT), hip circumference, waist-to-hip ratio and blood pressure in either group (P > 0.05 for all). Conclusion: These findings indicated that resveratrol supplementation in dose and duration used in this study did not affect most of the CVD risk factors in NAFLD patients. Further studies are warranted to explain more effects of resveratrol on CVD complications of NAFLD. Registration ID in IRCT: IRCT201511233664N16
Triggering of the Mw 7.2 Hawaii Earthquake of 4 May 2018 by a Dike Intrusion
Authors: Chen Kejie , Smith Jonathan D. , Avouac Jean‐Philippe , Liu Zhen , Song Y. Tony , Gualandi Adriano 
Published: February 2019

AbstractA Mw 7.2 earthquake struck the south flank of Kilauea, Hawaii, on 4 May 2018, following a period of volcanic unrest. To investigate its relationship with the stress changes induced by prior tectonic and magmatic activity, we model the coseismic slip distribution, preintrusion deformation, and dike intrusion using geodetic, seismic, and tsunami observations. The décollement beneath the south flank was creeping seaward by ~25 cm/year. Diking started on 20 April and led to fissure eruption on 3 May. The magmatic activity and creep resulted in an onshore U‐shaped zone of stress unloading, fringed by an off‐shore zone of stress buildup that apparently guided the 2018 rupture. It takes only 20 to 35 years at the preintrusion rate to accumulate a moment deficit equivalent to the moment that was released in 2018. This event falls short of balancing the moment budget since the 1975 Mw 7.7 earthquake.
Magma Reservoir Below Laguna del Maule Volcanic Field, Chile, Imaged With Surface‐Wave Tomography
Authors: Wespestad Crystal E. , Thurber Clifford H. , Andersen Nathan L. , Singer Brad S. , Cardona Carlos , Zeng Xiangfang , Bennington Ninfa L. , Keranen Katie , Peterson Dana E. , Cordell Darcy , Unsworth Martyn , Miller Craig , Williams‐Jones Glyn 
Published: February 2019

AbstractThe Laguna del Maule (LdM) volcanic field comprises the greatest concentration of postglacial rhyolite in the Andes and includes the products of ~40 km3 of explosive and effusive eruptions. Recent observations at LdM by interferometric synthetic aperture radar and global navigation satellite system geodesy have revealed inflation at rates exceeding 20 cm/year since 2007, capturing an ongoing period of growth of a potentially large upper crustal magma reservoir. Moreover, magnetotelluric and gravity studies indicate the presence of fluids and/or partial melt in the upper crust near the center of inflation. Petrologic observations imply repeated, rapid extraction of rhyolitic melt from crystal mush stored at depths of 4–6 km during at least the past 26 ka. We utilize multiple types of surface‐wave observations to constrain the location and geometry of low‐velocity domains beneath LdM. We present a three‐dimensional shear‐wave velocity model that delineates a ~450‐km3 shallow magma reservoir ~2 to 8 km below surface with an average melt fraction of ~5%. Interpretation of the seismic tomography in light of existing gravity, magnetotelluric, and geodetic observations supports this model and reveals variations in melt content and a deeper magma system feeding the shallow reservoir in greater detail than any of the geophysical methods alone. Geophysical imaging of the LdM magma system today is consistent with the petrologic inferences of the reservoir structure and growth during the past 20–60 kyr. Taken together with the ongoing unrest, a future rhyolite eruption of at least the scale of those common during the Holocene is a reasonable possibility.
Modeling the Seasonal Cycle of Iron and Carbon Fluxes in the Amundsen Sea Polynya, Antarctica
Authors: St‐Laurent P. , Yager P. L. , Sherrell R. M. , Oliver H. , Dinniman M. S. , Stammerjohn S. E. 
Published: February 2019

AbstractThe Amundsen Sea Polynya (ASP) is distinguished by having the highest net primary production per unit area in the coastal Antarctic. Recent studies have related this high productivity to the presence of fast‐melting ice shelves, but the mechanisms involved are not well understood. In this study we describe the first numerical model of the ASP to represent explicitly the ocean‐ice interactions, nitrogen and iron cycles, and the coastal circulation at high resolution. The study focuses on the seasonal cycle of iron and carbon, and the results are broadly consistent with field observations collected during the summer of 2010–2011. The simulated biogeochemical cycle is strongly controlled by light availability(dictated by sea ice, phytoplankton self‐shading, and variable sunlight). The micronutrient iron exhibits strong seasonality, where scavenging by biogenic particles and remineralization play large compensating roles. Lateral fluxes of iron are also important to the iron budget, and our results confirm the key role played by inputs of dissolved iron from the buoyancy‐driven circulation of melting ice shelf cavities (the “meltwater pump”). The model suggests that westward flowing coastal circulation plays two important roles: it provides additional iron to the ASP and it collects particulate organic matter generated by the bloom and transports it to the west of the ASP. As a result, maps of vertical particulate organic matter fluxes show highest fluxes in shelf regions located west of the productive central ASP. Overall, these model results improve our mechanistic understanding of the ASP bloom, while suggesting testable hypotheses for future field efforts.
Increased 5-HT2C receptor editing predisposes to PTSD-like behaviors and alters BDNF and cytokines signaling
Authors: Règue Mathilde , Poilbout Corinne , Martin Vincent , Franc Bernard , Lanfumey Laurence , Mongeau Raymond 
Published: February 2019

AbstractPost-traumatic stress disorder (PTSD) is a trauma- and stress-related disorder with dysregulated fear responses and neurobiological impairments, notably at neurotrophic and inflammation levels. Understanding the mechanisms underlying this disease is crucial to develop PTSD models that meet behavioral and neurobiological validity criteria as well as innovative therapeutic approaches. Serotonin 2C receptors (5-HT2CR) are known for their important role in anxiety, and mice having only the fully edited VGV isoform of 5-HT2CR, which thereby overexpressed brain 5-HT2CR, are of special interest to study PTSD predisposition. Innate and conditioned fear-related behaviors were assessed in VGV and wild-type mice. mRNA expression of brain-derived neurotrophic factor (BDNF), tissue-plasminogen activator (tPA), and pro-inflammatory cytokines (IL-6, IL-1β, and calcineurin) were measured by qRT-PCR. The effect of acute and chronic paroxetine was evaluated on both behavior and gene expression. VGV mice displayed greater fear expression, extensive fear extinction deficits, and fear generalization. Paroxetine restored fear extinction in VGV mice when administered acutely and decreased innate fear and fear generalization when administered chronically. In parallel, Bdnf, tPA, and pro-inflammatory cytokines mRNA levels were dysregulated in VGV mice. Bdnf and tPA mRNA expression was decreased in the hippocampus but increased in the amygdala, and chronic paroxetine normalized Bdnf mRNA levels both in the amygdala and the hippocampus. Amygdalar calcineurin mRNA level in VGV mice was also normalized by chronic paroxetine. VGV-transgenic mice displayed behavioral and neurobiological features that could be accessory to the investigation of PTSD and its treatment. Furthermore, these data point out to the role of 5-HT2CR in neuroplasticity and neuroinflammation.
Long non-coding RNA Irm enhances myogenic differentiation by interacting with MEF2D
Authors: Sui Yutong , Han Yu , Zhao Xingyu , Li Dongsong , Li Guangyu 
Published: February 2019

AbstractRecent studies suggest important roles for long non-coding RNAs as essential regulators of myogenic differentiation. Here, we report that lncRNA Irm is upregulated during myogenesis. Functional analyses show that the overexpression of Irm enhances myogenic differentiation, whereas the inhibition of Irm has completely opposite effects in vitro. Notably, the inhibition of Irm blocks damage-induced muscle regeneration in vivo. Mechanistically, Irm regulates the expression of myogenic genes by directly binding to MEF2D, which in turn promotes the assembly of MyoD/MEF2D on the regulatory elements of target genes. Collectively, we have identified a novel lncRNA that interacts with MEF2D to regulate myogenesis.
Earth system models underestimate carbon fixation by plants in the high latitudes
Authors: Winkler Alexander J. , Myneni Ranga B. , Alexandrov Georgii A. , Brovkin Victor 
Published: February 2019

AbstractMost Earth system models agree that land will continue to store carbon due to the physiological effects of rising CO2 concentration and climatic changes favoring plant growth in temperature-limited regions. But they largely disagree on the amount of carbon uptake. The historical CO2 increase has resulted in enhanced photosynthetic carbon fixation (Gross Primary Production, GPP), as can be evidenced from atmospheric CO2 concentration and satellite leaf area index measurements. Here, we use leaf area sensitivity to ambient CO2 from the past 36 years of satellite measurements to obtain an Emergent Constraint (EC) estimate of GPP enhancement in the northern high latitudes at two-times the pre-industrial CO2 concentration (3.4 ± 0.2 Pg C yr−1). We derive three independent comparable estimates from CO2 measurements and atmospheric inversions. Our EC estimate is 60% larger than the conventionally used multi-model average (44% higher at the global scale). This suggests that most models largely underestimate photosynthetic carbon fixation and therefore likely overestimate future atmospheric CO2 abundance and ensuing climate change, though not proportionately.
Kondo-like phonon scattering in thermoelectric clathrates
Authors: Ikeda M. S. , Euchner H. , Yan X. , Tomeš P. , Prokofiev A. , Prochaska L. , Lientschnig G. , Svagera R. , Hartmann S. , Gati E. , Lang M. , Paschen S. 
Published: February 2019

AbstractCrystalline solids are generally known as excellent heat conductors, amorphous materials or glasses as thermal insulators. It has thus come as a surprise that certain crystal structures defy this paradigm. A prominent example are type-I clathrates and other materials with guest-host structures. They sustain low-energy Einstein-like modes in their phonon spectra, but are also prone to various types of disorder and phonon-electron scattering and thus the mechanism responsible for their ultralow thermal conductivities has remained elusive. Our thermodynamic and transport measurements on various clathrate single crystal series and their comparison with ab initio simulations reveal an all phononic Kondo effect as origin. This insight devises design strategies to further suppress the thermal conductivity of clathrates and other related materials classes, with relevance for thermoelectric waste heat recovery and, more generally, phononic applications. It may also trigger theoretical work on strong correlation effects in phonon systems.
Extreme slow growth as alternative strategy to survive deep starvation in bacteria
Authors: Gray Declan A. , Dugar Gaurav , Gamba Pamela , Strahl Henrik , Jonker Martijs J. , Hamoen Leendert W. 
Published: February 2019

AbstractBacteria can become dormant or form spores when they are starved for nutrients. Here, we find that non-sporulating Bacillus subtilis cells can survive deep starvation conditions for many months. During this period, cells adopt an almost coccoid shape and become tolerant to antibiotics. Unexpectedly, these cells appear to be metabolically active and show a transcriptome profile very different from that of stationary phase cells. We show that these starved cells are not dormant but are growing and dividing, albeit with a doubling time close to 4 days. Very low nutrient levels, comparable to 10,000-fold diluted lysogeny broth (LB), are sufficient to sustain this growth. This extreme slow growth, which we propose to call ‘oligotrophic growth state’, provides an alternative strategy for B. subtilis to endure nutrient depletion and environmental stresses. Further work is warranted to test whether this state can be found in other bacterial species to survive deep starvation conditions.
Defining the structural basis for human alloantibody binding to human leukocyte antigen allele HLA-A*11:01
Authors: Gu Yue , Wong Yee Hwa , Liew Chong Wai , Chan Conrad E. Z. , Murali Tanusya M. , Yap Jiawei , Too Chien Tei , Purushotorman Kiren , Hamidinia Maryam , El Sahili Abbas , Goh Angeline T. H. , Teo Rachel Z. C. , Wood Kathryn J. , Hanson Brendon J. , Gascoigne Nicholas R. J. , Lescar Julien , Vathsala Anantharaman , MacAry Paul A. 
Published: February 2019

AbstractOur understanding of the conformational and electrostatic determinants that underlie targeting of human leukocyte antigens (HLA) by anti-HLA alloantibodies is principally based upon in silico modelling. Here we provide a biochemical/biophysical and functional characterization of a human monoclonal alloantibody specific for a common HLA type, HLA-A*11:01. We present a 2.4 Å resolution map of the binding interface of this antibody on HLA-A*11:01 and compare the structural determinants with those utilized by T-cell receptor (TCR), killer-cell immunoglobulin-like receptor (KIR) and CD8 on the same molecule. These data provide a mechanistic insight into the paratope−epitope relationship between an alloantibody and its target HLA molecule in a biological context where other immune receptors are concomitantly engaged. This has important implications for our interpretation of serologic binding patterns of anti-HLA antibodies in sensitized individuals and thus, for the biology of human alloresponses.
A systematic study on the influence of thermodynamic asymmetry of 5′-ends of siRNA duplexes in relation to their silencing potency
Authors: Lisowiec-Wąchnicka Jolanta , Bartyś Natalia , Pasternak Anna 
Published: February 2019

AbstractsiRNA molecules possess high potential as molecular tools and can be used as effective therapeutics in humans. One of the key steps in the action of these molecules is the choice of antisense strand by the RNA-induced silencing complex (RISC). To explain this process, we verified the theory which states that antisense strand selection is based on the thermodynamically less stable 5′ end of siRNA. Based on the studies presented herein, we observed that for the tested siRNA duplexes, the difference in the thermodynamic stability of the terminal, penultimate and pre-penultimate pairs in the duplex siRNA is not the dominant factor in antisense strand selection. We found that both strands in each tested siRNA molecule are used as an antisense strand. The introduction of modified nucleotides, whose impact on the thermodynamic stability of siRNA duplexes was studied, results in changes in antisense strand selection by the RISC complex. The presence of a modified residue often caused predominant selection of only one antisense strand which is at variance with the theory of siRNA strand bias.
Effects of bleaching-associated mass coral mortality on reef structural complexity across a gradient of local disturbance
Authors: Magel Jennifer M. T. , Burns John H. R. , Gates Ruth D. , Baum Julia K. 
Published: February 2019

AbstractStructural complexity underpins the ecological functioning of coral reefs. However, rising ocean temperatures and associated coral bleaching threaten the structural integrity of these important ecosystems. Despite the increased frequency of coral bleaching events, few studies to date have examined changes in three-dimensional (3D) reef structural complexity following severe bleaching. The influence of local stressors on reef complexity also remains poorly understood. In the wake of the 2015-2016 El Niño-induced mass coral bleaching event, we quantified the effects of severe heat stress on 3D reef structural complexity across a gradient of local human disturbance. Using Structure-from-Motion photogrammetry we created 3D reconstructions of permanent reef plots and observed substantial declines in reef structural complexity, measured as surface rugosity and terrain ruggedness, and a detectable loss of habitat volume one year after the bleaching event. 3D reef complexity also declined with increasing levels of human disturbance, and with decreasing densities of branching and massive corals. These findings improve our understanding of the effects of local and global stressors on the structural foundation of coral reef ecosystems. In the face of accelerating climate change, mitigating local stressors may increase reef structural complexity, thereby heightening reef resilience to future bleaching events.
A clean fuel cookstove is associated with improved lung function: Effect modification by age and secondhand tobacco smoke exposure
Authors: Mazumder Sarmila , Lee Alison , Dube Brinda , Mehra Divya , Khaing Phue , Taneja Sunita , Yan Beizhan , Chillrud Steven N. , Bhandari Nita , D’Armiento Jeanine M. 
Published: February 2019

AbstractHousehold air pollution (HAP) secondary to the burning of solid fuels is a major risk factor for the development of COPD. Our study seeks to examine the impact of a clean cookstove, liquid petroleum gas (LPG), on respiratory outcomes. Women (n = 200) from neighboring Indian communities, one cooking with LPG and one with biomass, were enrolled. Spirometry was performed. Relationships between primary cooking fuel and spirometry measures, as raw values, Global Lung Initiative (GLI) percent predicted (pp), and GLI z-scores, were examined using linear regression. Effect modification by age was explored. Women were young (average age 33.3 years), with low education (median 5.0 years), and the majority had multiple sources of air pollution exposures. Overall, the lung function in both groups was poor [FEV1 z-score median −2.05, IQR (−2.64, −1.41). Biomass was associated with lower FEV1/FVC (raw values −7.0, p = 0.04; GLI pp −7.62, p = 0.05, and z-score −0.86, p = 0.05) and FEF25–75 (GLI pp −25.78, p = 0.05, z-score −1.24, p = 0.05), after adjusting for confounders. Increasing impairment in lung function with age was found among biomass users (p-interaction = 0.01). In conclusion, use of a clean fuel cookstove may improve lung function. These findings have broad implications for research and public policy.
Acoustoelasticity Analysis of Transient Waves for Non-Invasive In Vivo Assessment of Urinary Bladder
Authors: Bayat Mahdi , Adabi Saba , Kumar Viksit , Gregory Adriana , Webb Jeremy , Denis Max , Kim Baehyung , Singh Aparna , Mynderse Lance , Husmann Douglas , Alizad Azra , Fatemi Mostafa 
Published: February 2019

AbstractA non-invasive method for measurement of the bladder wall nonlinear elastic behavior is presented. The method is based on acoustoelasticity modeling of the elasticity changes in bladder tissue modulus at different volumetric strain levels. At each volume, tissue strain is obtained from the real-time ultrasound images. Using acoustic radiation force, a transient Lamb wave is excited on the bladder wall and instantaneous modulus of shear elasticity is obtained from the 2-D Fourier analysis of the spatial-temporal dispersion maps. Measured elasticity and strain data are then used in an acoustoelasticity formulation to obtain the third order elastic coefficient, referred to as nonlinearity parameter A, and initial resting elasticity μ0. The method was tested in ex vivo porcine bladder samples (N = 9) before and after treatment with formalin. The estimated nonlinearity parameter, A, was significantly higher in the treated samples compared to intact (p < 0.00062). The proposed method was also applied on 16 patients with neurogenic bladders (10 compliant and 6 non-compliant subjects). The estimated nonlinearity parameter A was significantly higher in the non-compliant cases compared to the compliant (p < 0.0293). These preliminary results promise a new method for non-invasive evaluation of the bladder tissue nonlinearity which may serve as a new diagnostic and prognostic biomarker for management of the patients with neurogenic bladders.