bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tell it to Me Straight: The Benefits (and Struggles) of a Consumer‐driven Assessment Process
Authors: Kaufman Joy S. , Abraczinskas Michelle , Salusky Ida S. 
Published: August 2019

AbstractCommunity‐based Participatory Research (CBPR), where consumers participate in the design and execution of an evaluation, holds promise for increasing the validity and usefulness of evaluations of services. However, there is no literature comparing methods and outcomes of studies conducted by professional evaluators with those conducted through a consumer‐driven evaluation process. We attempt to fill this gap by presenting the methods and results from a qualitative evaluation conducted by professional evaluators along with one conducted by a team of consumer researchers who engaged in a CBPR process. This paper includes: (a) methods, and findings that emerged from these evaluations each tasked with examining similar issues within the same community; (b) description of the process used to train the team of consumer researchers whose economic and educational backgrounds are different than most evaluators; and (c) lessons learned about how to prepare for and work with common barriers to implementing a CBPR evaluation.
Photoenzymatic Approaches in Organic Synthesis
Authors: Chen Jie , Guan Zhi , He Yan‐Hong 
Published: August 2019

AbstractAs a green yet challenging field, photoenzymatic catalysis has sprung up in the past few years but mainly in the context of photocatalytic in situ regeneration of cofactors to facilitate enzymes’ native functions. In addition to this, some unprecedented chemical transformations have recently been achieved via novel pathways wherein many important products are obtained in satisfactory yields, sometimes even with excellent enantioselectivity. In this review, we highlight the latest advances of photoenzymatic approaches in organic synthesis, however, photocatalytic in situ regeneration of cofactors for enzymes is not included.
Rh(III)‐Catalyzed Direct C−H Cyanation of Arenes with p‐Toluenesulfonyl Cyanide
Authors: Liu Mingliang , You Erli , Cao Weiguo , Shi Jingjing 
Published: August 2019

AbstractHere an efficient and versatile method for cyanation using p‐toluenesulfonyl cyanide as a safe “CN” source under Rh(III)‐catalysis has been successfully developed. The reaction tolerates various functional groups and allows the synthesis of a wide range of (hetero)aryl nitriles in moderate to good yield.
Nickel‐Catalyzed Conversion of Enol Triflates into Alkenyl Halides
Authors: Hofstra Julie L. , Poremba Kelsey E. , Shimozono Alex M. , Reisman Sarah E. 
Published: August 2019

AbstractA Ni‐catalyzed halogenation of enol triflates was developed and it enables the synthesis of a broad range of alkenyl iodides, bromides, and chlorides under mild reaction conditions. The reaction utilizes inexpensive, bench‐stable Ni(OAc)2⋅4 H2O as a precatalyst and proceeds at room temperature in the presence of sub‐stoichiometric Zn and either 1,5‐cyclooctadiene or 4‐(N,N‐dimethylamino)pyridine.
Water hammer vibrations in pressurized water distribution system: Conceptual development of dynamic model and validation
Authors: Sankaranarayanan S  , Sivakumaran N  , Radhakrishnan T K  , Swaminathan G  
Published: August 2019

AbstractIn this paper, the dynamical behavior of water hammer (WH) caused vibrations by valve failures, and the corresponding impact of the vibrations over the water distribution system (WDS) is discussed. The existing mathematical model of WH is represented by partial Differential Equation (PDE) format, which is not compatible with the WDS model represented through Ordinary Differential Equation (ODE). The existing PDE model does not account the rate of change of valve dynamics. Thus, to overcome the abovementioned intricacies, the PDE is converted to a set of ordinary differential equations, and the valve coefficient is incorporated in the model. The WDS that is considered in this context has storage tank in every consumer node too, with regulating valves at the terminal ends of the pipelines. Various modes of pipeline valve failures are created, and the corresponding effects propagating throughout the WDS are studied in control aspects. The corresponding mathematical model in each mode of operations are also obtained. The simulation studies show the uncertainties induced by WH that interrupts the nominal operation of the WDS.
Microwave devulcanization of ground tire rubber and applicability in SBR compounds
Authors: Simon Dániel Ábel , Pirityi Dávid , Tamás‐Bényei Péter , Bárány Tamás 
Published: August 2019

ABSTRACTRubber recycling is a major environmental challenge, as their covalently crosslinked structure makes it impossible to reprocess via conventional polymer processing technologies. Devulcanization of rubber waste, whereby crosslinks are selectively broken, may provide a solution, as it allows it to be remolded into new shapes. We used two types of ground tire rubbers (GTRs) for this study; mechanically ground and waterjet‐milled GTRs with different particle sizes. First, we revealed the effects of GTR particle size on the devulcanization process. We examined the sol content of the samples before and after devulcanization with two different microwave ovens, a power‐controlled conventional one, and a temperature‐controlled laboratory oven. In the latter one, heating rate and maximum temperature were controlled. We studied the effects of temperature, atmosphere in which the rubber was treated, heating rate, and holding time at maximum temperature. We prepared styrene‐butadiene rubber‐based rubber compounds containing GTR and optimally devulcanized GTR (dGTR_WJ). The physical and mechanical properties of the samples were assessed. The results indicate that both GTR_WJ and dGTR_WJ have an accelerating and a mildly softening effect on curing and dGTR_WJ has a less significant negative effect on mechanical properties: 15 phr GTR_WJ has the same effect as 45 phr dGTR_WJ. © 2019 The Authors. Journal of Applied Polymer Science published by Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2020, 137, 48351.
Evaluation of physicochemical, thermomechanical, and structural properties of chickpea flour composite films reinforced with crystalline nanocellulose
Authors: Maftoonazad Neda , Badii Fojan , Mohamed Amal , Ramaswamy Hosahalli 
Published: August 2019

ABSTRACTChickpea flour–crystalline nano‐cellulose (CNC) composite films were prepared using chickpea flour as the film forming material, glycerol as the plasticizer and 2.5 to 10% CNC as reinforcement supplement. Mechanical properties of the composite films increased with an increase in the CNC content up to 5%. By inclusion of CNC up to 10%, the storage modulus of chickpea flour matrix increased by an order of magnitude from 7.3 to 86.4 MPa. The storage modulus of all samples, on the other hand, decreased as temperature increased. The Tg values measured by dynamic mechanical analysis (DMA) and differential scanning calorimetry (DSC) were shifted toward higher temperatures by the addition of CNC. The creep resistance of chickpea flour films increased again up to 5% added CNC, and strain sweep tests confirmed the extension of linear viscoelastic region. X‐ ray diffraction (XRD) confirmed a positive correlation between the degree of crystallinity of chickpea flour composties and CNC content. FTIR spectroscopy confirmed the molecular interaction between chickpea flour, glycerol and CNC. SEM results revealed agglomeration in the structure of the film with the addition of CNC beyond 5% and diminishing of surface homogeneity, while decreasing the pore size of chickpea flour matrix. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2020, 137, 48389.
New microsatellite markers for Xerophyta dasylirioides (Velloziaceae), an endemic species on Malagasy inselbergs
Authors: Rexroth Juliane , Krebes Lukas , Wöhrmann Tina , Harpke Dörte , Rabarimanarivo Marina , Phillipson Peter , Weising Kurt , Porembski Stefan 
Published: August 2019

PremiseMicrosatellite markers were developed for Xerophyta dasylirioides (Velloziaceae), a species endemic to the Malagasy inselbergs, to explore the impact of its island‐like distribution on genetic diversity and gene flow.Methods and ResultsA total of 7110 perfect microsatellite loci were recovered by shotgun sequencing on an Illumina MiSeq platform. Primer pairs were designed for 40 arbitrarily selected loci. Fifteen primer pairs that generated distinct PCR products were used to genotype 80 individuals of X. dasylirioides from three inselberg populations. All markers were polymorphic, revealing two to 17 alleles in the overall sampling. Levels of observed and expected heterozygosity per locus ranged from zero to 1.000 and from zero to 0.850, respectively. Success rates of cross‐amplification in 10 additional species of Xerophyta (X. croatii, X. decaryi, X. isaloensis, X. labatii, X. lewisiae, X. pinifolia, X. retinervis, X. setosa, X. spekei, X. tulearensis) ranged from zero to 70%.ConclusionsFifteen newly developed microsatellite markers provide a toolkit for assessing population genetic parameters of X. dasylirioides in its unique island‐like habitats.
Design, synthesis, and molecular docking studies of novel pyrazolyl 2‐aminopyrimidine derivatives as HSP90 inhibitors
Authors: Mettu Akhila , Talla Venu , Bajaj Deepti Madanlal , Subhashini Naikal James Prameela 
Published: August 2019

AbstractA series of novel pyrazolyl 2‐aminopyrimidine derivatives (7a‐t) were designed based on scaffold hopping techniques, synthesized and biologically evaluated for their HSP90 inhibition and anticancer activity. Several compounds exhibited potent HSP90 inhibition with IC50 values less than that of the reference standard 17‐AAG (1.25 µM). The most potent compound 7t displayed excellent HSP90 inhibition with an IC50 of 20 nM and in vitro antiproliferative potential against three cancer cell lines (IC50 < 5 µM). 7t also induced dose dependent degradation of client proteins (pHER2 and pERK1/2) in Western blot analysis. Several structural features of 7p‐t oriented the molecules to retain all the essential binding interactions with HSP90, as observed by rationalized docking studies. Therefore, the para‐nitrophenyl ring on the central pyrazole ring along with the 2‐amino group on the pyrimidine ring are the crucial features in the development of novel HSP90 inhibitors based on this scaffold for targeted anticancer therapy.
Cheating: One common morality for gains and losses but two components of morality itself
Authors: Markiewicz Łukasz , Czupryna Marcin 
Published: August 2019

AbstractPrevious studies show that decision makers (DMs) lie more to avoid a loss than achieve a gain. Two compelling mechanisms might explain this observation. One assumes that lying is a risky activity and relates to the shape of the monetary value function described by prospect theory, which assumes (a) increased risk taking for loss frames and (b) an asymmetry between the perceived values of losses and gains. The other relates to the importance of self‐esteem functions as expressed in self‐concept maintenance models, self‐esteem issues being weighed against monetary issues. This alternative explanation assumes that a loss frame serves as a factor lowering moral considerations. We report an experimental study presenting sets of lotteries to DMs, once in a moral context and once in a traditional probabilistic context. The results show that DMs take less risk when lotteries are presented in a moral context. It is also shown that DMs take more risk for losses than gains, this holding for both the moral and probabilistic contexts. This latter result suggests that loss/gain asymmetry can be completely explained by prospect theory factors, and framing makes no difference to the valuing of moral considerations.
Comparative study of two cephalosporin antibiotics binding to calf thymus DNA by multispectroscopy, electrochemistry, and molecular docking
Authors: Huang Sheng‐Chao , Cheng Li‐Yang , Yang Jing , Hu Yan‐Jun 
Published: August 2019

AbstractThe over‐use of antibiotics has caused a number of problems such as contamination of antibiotic residues and virus resistance, and therefore has attracted global attention. In this study, spectroscopic techniques and molecular docking were employed to predict conformational changes and binding interaction between two cephalosporins (cefaclor and cefixime) and calf thymus DNA (ctDNA). Fluorescence and UV–vis spectra suggested that static quenching was predominant and cephalosporin bound to the groove region of ctDNA. Binding parameters calculated by the Stern–Volmer and Scatchard equations showed that cephalosporin bound to ctDNA with a binding affinity in the order of 103 L mol−1. Thermodynamic parameters further indicated that the reaction was a spontaneous process driven by enthalpy and entropy, and that the main binding force was an electrostatic force. The effects of iodide, denaturant, thermal denaturation and pH on a cephalosporin–Hoechst–DNA complex were also studied, and the results confirmed that cephalosporin bound to the groove area of DNA. Finally, these results were further confirmed by molecular docking and electrochemical studies.
Clinical relevance of ticagrelor monotherapy following 1‐month dual antiplatelet therapy after bifurcation percutaneous coronary intervention: Insight from GLOBAL LEADERS trial
Authors: Kogame Norihiro , Chichareon Ply , De Wilder Kenneth , Takahashi Kuniaki , Modolo Rodrigo , Chang Chun Chin , Tomaniak Mariusz , Komiyama Hidenori , Chieffo Alaide , Colombo Antonio , Garg Scot , Louvard Yves , Jüni Peter , G. Steg Philippe , Hamm Christian , Vranckx Pascal , Valgimigli Marco , Windecker Stephan , Stoll Hans‐Peter , Onuma Yoshinobu , Janssens Luc , Serruys Patrick W. 
Published: August 2019

AbstractBackgroundThe aim of this study was to investigate the impact of ticagrelor monotherapy following 1‐month dual antiplatelet therapy (DAPT) after percutaneous coronary intervention (PCI) for bifurcation lesions.MethodsGLOBAL LEADERS was a randomized, superiority, all‐comers trial comparing 1‐month DAPT with ticagrelor and aspirin followed by 23‐month ticagrelor monotherapy (experimental treatment) with standard 12‐month DAPT followed by 12‐month aspirin monotherapy (reference treatment) in patients treated with a biolimus A9‐eluting stent. The primary endpoint was a composite of all‐cause death or new Q‐wave myocardial infarction (MI) at 2 years.ResultsAmong the 15,845 patients included in this subgroup analysis, 2,498 patients (15.8%) underwent PCI for at least one bifurcation lesion. The incidence of the primary endpoint was similar between the bifurcation and nonbifurcation groups (4.7 vs. 4.0%, p = .083). The experimental treatment had no significant effect on the primary endpoint according to the presence/absence of a bifurcation lesion (bifurcation: hazard ratio [HR]: 0.74, 95% confidence interval [CI]: 0.51–1.07; nonbifurcation: HR: 0.90, 95% CI: 0.76–1.07, p for interaction = .343), but was associated with significant reduction in definite or probable stent thrombosis (p for interaction = .022) and significant excess of stroke (p for interaction = .018) when compared with the reference treatment.ConclusionsAfter PCI for bifurcation lesions using 1‐month of DAPT followed by ticagrelor monotherapy for 23 months did not demonstrate explicit benefit regarding all‐cause death or new Q‐wave MI as in the overall trial.
Percutaneous coronary intervention and in‐hospital outcomes in patients with leukemia: a nationwide analysis
Authors: Potts Jessica , Mohamed Mohamed O. , Lopez Mattei Juan C. , Iliescu Cezar A. , Konopleva Marina , Rashid Muhammad , Bagur Rodrigo , Mamas Mamas A. 
Published: August 2019

AbstractObjectivesTo examine the association between current leukemia diagnosis and in‐hospital clinical outcomes in patients undergoing percutaneous coronary intervention (PCI) in the United States.BackgroundLeukemia is the most common hematological malignancy and is associated with an increased risk of thrombotic and bleeding complications in patients undergoing PCI. There are limited data around clinical outcomes of leukemia patients undergoing PCI.MethodsWe used the National Inpatient Sample to investigate the outcomes of leukemia patients undergoing PCI between 2004 and 2014. Patients were then subdivided into diagnoses of acute myeloid leukemia (AML) or chronic myeloid leukemia and acute lymphoid leukemia or chronic lymphoid leukemia (CLL). Multiple logistic regressions were used to study the association of a leukemia diagnosis with in‐hospital outcomes: mortality, bleeding, vascular and cardiac complications, and stroke.ResultsThere were 6,561,445 records of patients who underwent PCI during the study time, of which 15,789 patients had a diagnosis of leukemia. The most common leukemia subtype was CLL accounting for 75% of the cohort (n = 10,800). After multivariable adjustment, a leukemia diagnosis was associated with significantly increased odds of in‐hospital mortality (odds ratio [OR]: 1.41; 95% confidence interval [CI]: [1.11–1.79]) and bleeding (OR: 1.87; 95% CI: [1.56–2.09]), whereas patients with AML had a fivefold increase of in‐hospital mortality (OR: 5.38; 95% CI: [2.94–9.76]).ConclusionsPatients with current diagnosis of leukemia are at increased risk of procedure‐related complications following PCI. A multidisciplinary approach is needed among interventional cardiologists, oncologists, and hematologists to minimize procedural complications and improve outcomes in this high‐risk cohort.
Anisotropic Nanoporous Nickel Obtained through the Chemical Dealloying of Y2Ni7 for the Comprehension of Anode Surface Chemistry of Ni‐MH Batteries
Authors: Madern Nicolas , Monnier Judith , Cachet‐Vivier Christine , Zhang Junxian , Bastide Stéphane , Paul‐Boncour Valérie , Latroche Michel 
Published: August 2019

AbstractFor the first time, the nickel layer formed during the corrosion of intermetallic alloys with a stacked structure has been isolated. This nickel layer has been produced by chemical dealloying of Y2Ni7 through a corrosion process in alkaline medium. This anisotropic and nanoporous phase has been fully characterized regarding its morphology, chemical and structural properties, as well as its electrochemical behavior. The metallic phase is made of interconnected nanocrystalline cubic nickel, showing preferential orientation and nanopores. A cavity microelectrode has been used in addition to classical methods using bulk electrodes for electrochemical investigations of the layer. This full characterization is of primary importance to better understand the behavior of metallic anodes in Ni‐MH batteries upon cycling and to ensure a longer lifetime.
Dual Binding Mode of Metallacarborane Produces a Robust Shield on Proteins
Authors: Fuentes Isabel , Pujols Jordi , Viñas Clara , Ventura Salvador , Teixidor Francesc 
Published: August 2019

AbstractAn inorganic sandwich molecule, Na[Co(C2B9H11)2], able to produce vesicles through self‐assembly and known to produce strong dihydrogen‐bond interactions with amine groups is capable of interacting with proteins. This dual non‐bonding ability of Na[Co(C2B9H11)2] is what makes this molecule unique: it can be firmly anchored to a protein surface and is capable of extending over it. To prove this, the widely available bovine serum albumin (BSA), which has many pendant amino groups in its structure, has been taken as the model protein. It has been found that around 100 molecules of Na[Co(C2B9H11)2] preserve the native structure of BSA, while endorsing it with a significantly increased stability with respect to chemical‐ and thermal‐induced denaturation due to efficient encapsulation. The advantages of this encapsulation technique are two‐fold; the first is its simplicity as it relies on the anchoring capacity of Na[Co(C2B9H11)2] to the surface of the protein through the amine‐containing residues and the second is its self‐assembling capacity allowing it to spread across the surface. The dense shield of protection offered by Na[Co(C2B9H11)2] has been demonstrated by the inhibition of BSA pseudo‐esterase activity, which indicates that the inorganic corset around BSA protects its reactive surface residues, thereby preventing their acetylation.
Performance of an artificial intelligence algorithm for reporting urine cytopathology
Authors: Sanghvi Adit B. , Allen Erastus Z. , Callenberg Keith M. , Pantanowitz Liron 
Published: August 2019

BackgroundUnlike Papanicolaou tests, there are no commercially available computer‐assisted automated screening systems for urine specimens. Despite The Paris System for Reporting Urinary Cytology, there still is poor interobserver agreement with urine cytology and many cases in which a definitive diagnosis cannot be made. In the current study, the authors have reported on the development of an image algorithm that applies computational methods to digitized liquid‐based urine cytology slides.MethodsA total of 2405 archival ThinPrep glass slides, including voided and instrumented urine cytology cases, were digitized. A deep learning computational pipeline with multiple tiers of convolutional neural network models was developed for processing whole slide images (WSIs) and predicting diagnoses. The algorithm was validated using a separate test data set comprised of consecutive cases encountered in routine clinical practice.ResultsThere were 1.9 million urothelial cells analyzed. An average of 5400 urothelial cells were identified in each WSI. The algorithm achieved an area under the curve of 0.88 (95% CI, 0.83‐0.93). Using the optimal operating point, the algorithm's sensitivity was 79.5% (95% CI, 64.7%‐90.2%) and the specificity was 84.5% (95% CI, 81.6%‐87.1%) for high‐grade urothelial carcinoma.ConclusionsThe authors successfully developed a computational algorithm capable of accurately analyzing WSIs of urine cytology cases. Compared with prior studies, this effort used a much larger data set, exploited whole slide–level and not just cell‐level features, and used a cell gallery to display the algorithm's output for easy end‐user review. This algorithm provides computer‐assisted interpretation of urine cytology cases, akin to the machine learning technology currently used for automated Papanicolaou test screening.
Detection of Organic Vapors Using Tamm Mode Based Devices Built from Mesoporous Oxide Thin Films
Authors: Sansierra M. Constanza , Morrone Josefina , Cornacchiulo Franco , Fuertes M. Cecilia , Angelomé Paula C. 
Published: August 2019

AbstractIn this work, Tamm mode based devices were synthesized using mesoporous thin films as building blocks. Several systems were designed and built, based on silicon and titanium mesoporous oxides obtained through amphiphilic molecules templating approach. The devices were evaluated for organic vapor detection and the obtained results demonstrate that the developed Tamm devices can be used for such purpose. Distributed Bragg reflectors (DBRs) were also synthesized and evaluated as a comparison. In both cases, the detection of organic vapors is possible thanks to capillary condensation inside the well‐ordered and accessible porosity that give rise to equivalent results to the ones obtained for the detection of liquids. Both kinds of devices behave in a similar way, but the figure of merit for the Tamm mode based ones is between two and three times larger due to the smaller width of the sensitive band. Moreover, it was demonstrated that the response time of the sensor is less than 80 s in all tested cases. In addition, such parameter clearly depends on both the physicochemical characteristics of the solvents (in particular, boiling temperature and vapor pressure) and the characteristics of the sensor itself. The results presented in this work represent a proof of concept towards the production of robust and reusable detection devices based on the combination of functional mesoporous thin films and the Tamm mode.