bluuebunny/crossref_metadata_2025_split huggingface dataset:
A GESTÃO LOGÍSTICA DE ARMAZENAGEM E SUAS RELAÇÕES COM A VERTICALIZAÇÃO E TERCEIRIZAÇÃO NA EMPRESA
Authors: Dalongaro Roberto Carlos , Feijó Moura Révis Cetiano , Lopes Alceu de Oliveira , Lucca Luiz Lorimar , Wesz Luis Fernando Peixoto 
Published: March 2018

<p>Este trabalho pretende abordar alguns aspectos relacionados aos conceitos e às operações observados na verticalização e na terceirização da armazenagem e distribuição de produtos. Apresenta-se os centros de distribuição (CDs), como elemento de estudo. Ao longo do trabalho, são caracterizados diversos pontos relevantes: a importância da armazenagem na logística, conceitos e funções básicas dos CDs, vantagens em sua adoção. Por último, é apresentado um panorama do comparativo entre investir na verticalização da logística ou terceirizar a armazenagem e a distribuição dos produtos. Os objetivos principais do presente trabalho é analisar os aspectos relevantes da terceirização e verticalização dos serviços logísticos, como também estimar uma receita gerada pelo investimento em um CD dentro do processo de verticalização da logística. Com isso se explora também a seguinte problemática. Com base na temática de estudo proposta. É possível que uma empresa de eletrodomésticos recupere o valor investido em um centro de distribuição com 05 anos de operação? A armazenagem possui um aspecto de elevada consideração no processo de negócios junto ao mercado, pois assimila uma parcela significativa dos custos logísticos na cadeia de suprimentos.</p><p><strong> </strong></p><p><strong> </strong></p><p><strong>Palavras-chaves: </strong>Logística, Armazenagem, Verticalização, Terceirização. <strong> </strong></p>
ESTRATÉGIAS PARA GESTÃO DE PESSOAS, CAPACIDADES DINÂMICAS E AS REDES DE COOPERAÇÃO INTERORGANIZACIONAIS
Authors: Da Fonseca Capssa Lima Sausen Juliana , Viana Cardoso Vanilson , Marlene Seide Froemming Lurdes , Luís Allebrandt Sérgio , Adelar Mueller Airton 
Published: March 2018

<p>Gestão estratégica de pessoas, capacidades dinâmicas e redes interorganizacionais de cooperação são temáticas contemporâneas e emergentes nas áreas de gestão estratégica e de estudos organizacionais. Desta forma, o artigo utilizou como metodologia pesquisa bibliográfica em livros, artigos em revista e em endereço eletrônico, com o objetivo de discutir as relações epistemológicas e metodológicas destas três temáticas. Conclui-se que gestão estratégica de pessoas, capacidades dinâmicas e redes interorganizacionais de cooperação estão bastante relacionadas entre si e que, se bem planejadas e integradas, contribuem para o desenvolvimento e a sustentabilidade das organizações e das pessoas envolvidas nas relações de cooperação no cenário competitivo dos ambientes corporativos. Para fins de aprofundamento dos estudos e de aplicação empírica, sugere-se estudos de caso envolvendo a sistematização das três temáticas.</p><p> </p>
Equilibrium Analysis of Desiccated Zone Growth during Radio-Frequency Heating
Authors: Irani Mazda , Saeedfar Amin 
Published: March 2018

Abstract
SAGD is an energy-intensive process with large amount of greenhouse gas (GHG) emissions and required water treatment. One option to reduce emissions and water is to use electromagnetic (EM) heating in either the induction (medium frequency) or radio frequency (RF) ranges. Since the early 1970s, research into the use of RF energy to effectively heat heavy oil reservoirs has led to incremental technology advancements. Since 2009, the Effective Solvent Extraction Incorporating Electromagnetic Heating (ESEIEH™, pronounced "easy") consortium suggested a process named similarly that dielectric heating of oil sand is combined with the injection of a solvent such as propane or butane to reduce bitumen viscosity. In January 2012, the mine face test was declared a success and confirmed the ability to generate, propagate, and distribute electromagnetic heat in an oil sand formation. Phase II of ESEIEH™ exploring scaled pilot tests with horizontal antenna in Suncor’s Dover facility is under developing. To distribute electromagnetic heating into the reservoir creation of desiccated zone and its controlled growth is a key. Since the reservoir is an electrically lossy environment, the growth of desiccated zone as a lossless medium helps the electromagnetic fields to propagate deeper into the formation and associated heating is also further developed within the reservoir. The water will continue to vaporize and move away from the "flashed or desiccated zone" at a rate which diminishes with time. Eventually it reaches the equilibrium condition that it cannot grow with given delivered RF power from the radiating antenna. In this study, the desiccated zone extension at its equilibrium is calculated on the basis of this concept to prevent the zone from collapsing. In this process, water should vaporize and leaks into reservoir to create the flow rate normal to the desiccated zone surface that pushes the water back and grow the zone. Another highlight on this study is to provide the solution for RF-heating avoiding the Lambert’s law or plane-wave assumption. Lambert’s law is (only) accurate and valid in guided-microwave structures or when the EM radiating source is far from the receiving load (relative to the wavelength), such as in optical regime or in telecommunication applications. Although, for heating applications, the maximum energy dissipation of RF waves takes place in the near-field region and not in the far-field region, hence, Lambert’s law does not give a correct solution in these cases. As a result of this study minimum required power is a function of reservoir mobility or in-situ water relative permeability. If efficiency of antenna is not high enough and reservoir mobility is greater than 10-3 then the RF power transmission system could not deliver enough energy to grow the desiccated zone.
Impact of climate change on the blue water footprint of agriculture on a regional scale
Authors: Huang Huiping , Han Yuping , Jia Dongdong 
Published: March 2018

Abstract
In the case study of Tangshan city, Hebei Province, China, this paper analyzes the temporal change of the blue agricultural water footprint (WF) during 1991–2016 and discusses the applicability of different climate change models during 2017–2050. Results show effective rainfall, wind speed and maximum temperature are leading factors influencing the blue agricultural WF. Relative error analysis indicates that the HadGEM2-ES model is the most applicable for climate change projections in the period of 2017–2050. Agricultural blue WF is about 1.8 billion m3 in RCP2.6, RCP4.5 and RCP8.5 emission scenarios, which is almost equal to the average value during 1991–2016.
Bioassays and In Silico Methods in the Identification of Human DNA Topoisomerase IIα Inhibitors
Authors: Bergant Kaja , Janezic Matej , Perdih Andrej 
Published: March 2018

Background:
The family of DNA topoisomerases comprises a group of enzymes
that catalyse the induction of topological changes to DNA. These enzymes play a role in the
cell replication machinery and are, therefore, important targets for anticancer drugs - with human
DNA topoisomerase IIα being one of the most prominent. Active compounds targeting
this enzyme are classified into two groups with diverse mechanisms of action: DNA poisons
act by stabilizing a covalent cleavage complex between DNA and the topoisomerase enzyme,
transforming it into a cellular toxin, while the second diverse group of catalytic inhibitors,
provides novel inhibition avenues for tackling this enzyme due to frequent occurrence of side
effects observed during the DNA poison therapy.

Methods:
Based on a comprehensive literature search we present an overview of available
bioassays and in silico methods in the identification of human DNA topoisomerase IIα inhibitors.

Results and Conclusion:
A comprehensive outline of the available methods and approaches
that explore in detail the in vitro mechanistic and functional aspects of the topoisomerase IIα
inhibition of both topo IIα inhibitor groups is presented. The utilized in vitro cell-based assays
and in vivo studies to further explore the validated topo IIα inhibitors in subsequent preclinical
stages of the drug discovery are discussed. The potential of in silico methods in topoisomerase
IIα inhibitor discovery is outlined. A list of practical guidelines was compiled to aid new as
well experienced researchers in how to optimally approach the design of targeted inhibitors
and validation in the preclinical drug development stages.
Acyclovir in the Treatment of Herpes Viruses – A Review
Authors: Kłysik Katarzyna , Pietraszek Aneta , Karewicz Anna , Nowakowska Maria 
Published: March 2018

Background:
Herpes Simplex (HSV) viruses are widely spread, highly contagious
human pathogens. The statistics indicate that 50-90% of adults worldwide are seropositive for
these viruses, mainly HSV-1 and HSV-2. The primary infection results in the appearance of
watery blisters (cold sores) on the skin, lips, tongue, buccal mucosa or genitals. The ocular
infection is the major cause of corneal blindness in the Western World. Once the HSV virus
enters human body, it cannot be completely eradicated because HSV viruses are able to
change into their latent form which can survive the treatment. The viron resides in trigeminal
ganglia of the host, who becomes vulnerable to the reoccurrence of the disease during the
whole lifespan. The neurotropic and neuro-invasive properties of HSV are responsible for
neurodegenerative illnesses, such as Alzheimer's disease. Acyclovir and its analogues, being
the inhibitors of the viral DNA replication, are the only approved medicines for HSV infection
therapies.

Objective:
The current paper presents the up-to-date overview of the important pharmacological
features of acyclovir, its analogues and their delivery systems including the mechanism of
action, routes of administration, absorption and metabolism, as well as side effects of the therapy.

Conclusion:
Acyclovir remains the gold standard in the treatment of herpes virus infections,
mainly due to the emerging of the new delivery systems improving considerably its bioavailability.
The analogues of acyclovir, especially their esters, characterized by significantly
higher bioavailability and safety, may gradually replace acyclovir in selected applications.
Apoptin, A Versatile Protein with Selective Antitumor Activity
Authors: Castro Jessica , Ribo Marc , Benito Antoni , Vilanova Maria 
Published: March 2018

Background:
Research in the field of antitumor chemotherapeutics pursues a key issue, drug
selectivity for cancer cells. In the last 20 years, a group of proteins has attracted scientific interest as
cancer chemotherapeutics due to their ability to specifically kill cancer cells while leaving normal cells
undamaged. One of these proteins is apoptin.

Methods:
In this study, the recent available literature regarding cell death mechanisms induced by
apoptin has been reviewed. Delivering this drug to tumor cells is a challenge because it spontaneously
forms soluble non-covalent aggregates. This led us to include in this review the different approaches for
obtaining the maximum efficiency of apoptin entry to cancer cells.

Results:
This review provides an up-to-date summary of the mechanisms by which apoptin induces selective
apoptosis in tumor cells while leaving normal cells undamaged. It highlights the relationship between
the apoptosis mechanism induced by this protein and its functional motifs. Apoptin has been described
as an intrinsically disordered protein, which explains its ability to interact with multiple partners
and affect multiple pathways inside the cell. Characterization of the different partners and pathways induced
by apoptin has begun to shed light on the molecular basis of apoptin’s tumor-selective cytotoxicity.

Conclusion:
The findings confirm the interest in apoptin as a potentially safe antitumor drug. Research
still needed to be conducted to find an effective way to deliver apoptin for use in clinics.
Biotechnological Production of Pharmaceuticals and Biopharmaceuticals in Plant Cell and Organ Cultures
Authors: Hidalgo Diego , Sanchez Raul , Lalaleo Liliana , Bonfill Mercedes , Corchete Purificacion , Palazon Javier 
Published: March 2018

Background:
Plant biofactories are biotechnological platforms based on plant cell and organ
cultures used for the production of pharmaceuticals and biopharmaceuticals, although to date only a few of
these systems have successfully been implemented at an industrial level. Metabolic engineering is possibly
the most straightforward strategy to boost pharmaceutical production in plant biofactories, but social opposition
to the use of GMOs means empirical approaches are still being used.
<P><P>
Plant secondary metabolism involves thousands of different enzymes, some of which catalyze specific
reactions, giving one product from a particular substrate, whereas others can yield multiple products from
the same substrate. This trait opens plant cell biofactories to new applications, in which the natural metabolic
machinery of plants can be harnessed for the bioconversion of phytochemicals or even the production
of new bioactive compounds. Synthetic biological pipelines involving the bioconversion of natural
substrates into products with a high market value may be established by the heterologous expression of
target metabolic genes in model plants.
<P><P>
Objective: To summarize the state of the art of plant biofactories and their applications for the pipeline
production of cosme-, pharma- and biopharmaceuticals.
<P><P>
Results: In order to demonstrate the great potential of plant biofactories for multiple applications in the
biotechnological production of pharmaceuticals and biopharmaceuticals, this review broadly covers the
following: plant biofactories based on cell and hairy root cultures; secondary metabolite production;
biotransformation reactions; metabolic engineering tools applied in plant biofactories; and biopharmaceutical
production.
Plant-produced Recombinant Influenza A Vaccines Based on the M2e Peptide
Authors: Mardanova Eugenia S. , Ravin Nikolai V. 
Published: March 2018

Background:
Influenza is a widely distributed infection that almost annually causes seasonal epidemics.
The current egg-based platforms for influenza vaccine production are facing a number of challenges and are
failing to satisfy the global demand in the case of pandemics due to the long production time. Recombinant vaccines
are an alternative that can be quickly produced in high quantities in standard expression systems.

Methods:
: Plants may become a promising biofactory for the large-scale production of recombinant proteins due
to low cost, scalability, and safety. Plant-based expression systems have been used to produce recombinant vaccines
against influenza based on two targets; the major surface antigen hemagglutinin and the transmembrane
protein M2.
<P>
Results: Different forms of recombinant hemagglutinin were successfully expressed in plants, and some plantproduced
vaccines based on hemagglutinin were successfully tested in clinical trials. However, these vaccines
remain strain specific, while the highly conserved extracellular domain of the M2 protein (M2e) could be used for
the development of a universal influenza vaccine. In this review, the state of the art in developing plant-produced
influenza vaccines based on M2e is presented and placed in perspective. A number of strategies to produce M2e
in an immunogenic form in plants have been reported, including its presentation on the surface of plant viruses or
virus-like particles formed by capsid proteins, linkage to bacterial flagellin, and targeting to protein bodies.

Conclusion:
Some M2e-based vaccine candidates were produced at high levels (up to 1 mg/g of fresh plant tissue)
and were shown to be capable of stimulating broad-range protective immunity.
Hypnotic Effect of Portulaca oleracea on Pentobarbital-Induced Sleep in Mice
Authors: Hamedi Shokouhsadat , Forouzanfar Fatemeh , Rakhshandeh Hassan , Arian Amirali 
Published: March 2018

Objective:
In Iranian Traditional Medicine, the herbs with cold and wet temperament can help
to improve insomnia. Portulaca oleracea has a cold and wet temperament, so the present study was carried
out to investigate the sleep-prolonging effect of Portulaca oleracea.

Methods:
This work was an experimental study on mice which were randomly divided into these
groups: saline (control); Diazepam: positive control); hydro-alcoholic extract of Portulaca oleracea
(12.5, 25, 50, 75 and 100 mg/kg) by Soxhlet apparatus and maceration; in the effective (dose25 mg/kg),
different fractions of extract were tested. Ethyl acetate fraction (EAF:); N hexane fraction (n-HF); water
fraction (WF). All the test compounds were injected intraperitoneally (IP) 30 minutes before pentobarbital
administration (30 mg/kg). Duration and latency of pentobarbital-induced sleep were recorded. Also,
LD50 of Portulaca oleracea extract was determined and the possible neurotoxicity of the extract was
tested on neural PC12 cells. Besides, 30 min after administration of hydroalcoholic extract (HAE) motor
coordination (rota-rod test) was assessed.

Results:
HAE increased the duration of pentobarbital-induced sleep at doses of 25, 50, 75 and 100
mg/kg. The hypnotic effect of HAE was comparable to that induced by diazepam. Similarly, WF, EAF,
and NHF at 25 mg/kg could increase sleep duration. The sleep latency was decreased by HAE and NHF
but not by WF and EAF. The LD50 value for HAE was found to be 4.8 g/Kg. HAE and its fractions did
not show neurotoxic effect in cultured PC12-cell line, also HAE did not affect the animals performance
on the rotarod test.

Conclusion:
The present data demonstrated that Portulaca oleracea potentiates sleeping behaviors. The
main components responsible for the hypnotic effects of this plant is most likely a non-polar agents
which is found in NHF. Isolation of the active constituents may yield a novel sedative drug.
Brassica Nigra: Ethopharmacological Review of a Routinely Used Condiment
Authors: Agrawal Surendra , Yallatikar Tapasya , Gurjar Pravina 
Published: March 2018

Background:
Brassica nigra belonging to the family Brassicaceae (syn – black mustard)
comprises of dried seeds and is widely cultivated in Mediterranean region and various other countries
like India and Europe. The Plant is neither reported in any official book nor reported systematically
for pharmacological effects.

Methods:
We undertook a structured search of all the official books including pharmacopoeias and
ayurvedic textbooks. The data was collected, sorted and compiled to bring the chemical constituents
and uses of B. nigra.

Results:
B. nigra contains glycosinolates which undergoes hydrolysis in the presence of myrosinase
enzyme yields allyl isothiocyante. The bitter taste and pungent odor is due to the isothiocyanates.
B. Nigra shows various activities that are medically important such as anticancer, anti-bacterial, antifungal,
anti-helminthic, protection against renal and hepatic toxicity and can also be used in diabetes
treatment. Black mustards are also used in cardiovascular and neurological disorders.

Conclusion:
The present review explores the historical background including the macroscopic and
microscopic characteristics, chemical constituents, pharmacological action, various evaluation
parameters, formulations and uses of black mustard.
Skin Spotting Variation Associated with Biometric and Reproductive Parameters in Naturalized Populations of Rainbow Trout, Oncorhynchus mykiss, from Southern Chile
Authors: Colihueque Nelson , Estay Francisco Javier , Yáñez Miguel 
Published: March 2018

Background:Skin pigmentation in fish is involved in various biological processes. In salmonids, the interactions of skin spottiness with biometric and reproductive parameters are mostly unknown, especially in naturalized populations influenced by different ecological factors.Objective:To associate skin spottiness variation with biometric and reproductive parameters in broodstocks of naturalized rainbow trout populations from southern Chile.Method:The number of dark spots below the lateral line was assessed in male and female broodstocks of rainbow trout from two reproductive seasons, years 2007 and 2012, and then this dataset was associated with biometric and reproductive parameters of the same individuals, using multivariate data analysis in the form of stepwise forward multiple regression.Results:Male body weight from year 2007 had a significant negative influence on the number of dark spots below the lateral line (P< 0.01), while the reproductive variables egg diameter and spawning time of females from years 2007 and 2012, respectively, had a significant positive influence on this parameter (P< 0.01).Conclusion:Our results indicate that there are male biometric parameters with a significant negative influence on skin spottiness. Our data also reveal that some reproductive parameters have a positive influence on skin spottiness. The identification of these reproductive parameters related to spottiness variation would reflect the reproductive quality of female broodstocks living in natural environments.
Application of the Risk‐Based Early Warning Method in a Fracture‐Karst Water Source, North China
Authors: Guo Yongli , Wu Qing , Li Changsuo , Zhao Zhenhua , Sun Bin , He Shiyi , Jiang Guanghui , Zhai Yuanzheng , Guo Fang 
Published: March 2018

ABSTRACT: The paper proposes a risk‐based early warning considering characteristics of fracture‐karst aquifer in North China and applied it in a super‐large fracture‐karst water source. Groundwater vulnerability, types of land use, water abundance, transmissivity and spatial temporal variation of groundwater quality were chosen as indexes of the method. Weights of factors were obtained by using AHP method based on relative importance of factors, maps of factors were zoned by GIS, early warning map was conducted based on extension theory with the help of GIS, ENVI+IDL. The early warning map fused five factors very well, serious and tremendous warning areas are mainly located in northwest and east with high or relatively high transmissivity and groundwater pollutant loading, and obviously deteriorated or deteriorated trend of petroleum. The early warning map warns people where more attention should be paid, and the paper guides decision making to take appropriate protection actions in different warning levels areas.
Liquid‐Gas Mass Transfer of Volatile Substances in an Energy Dissipating Structure
Authors: Matias Natércia , Ferreira Filipa , Matos José Saldanha , Nielsen Asbjørn Haaning , Vollertsen Jes 
Published: March 2018

ABSTRACT: Mass transfer of a range of volatile substances was studied under highly turbulent conditions. The applied setup mimicked drop structures, where the release of volatile organic carbons likely occurs at a high rate. The experiments covered several substances in a range of resistances from residing entirely in the liquid film to being fully in the gas film. The two‐film theory yielded a good prediction of the whole measured range. This allowed the experimental validation of a method where two reference substances are applied, to determine the transfer of any other substance ‐ independently of where its resistance to mass transfer resides. One finding was that the range of dimensionless Henry's constants, where both films contributed by more than 5%, was 0.0027 to 1.05, which is over five times higher than the accepted rule of thumb (0.0005–0.18). Another finding was that the ratio between the liquid and the gas film mass transfer coefficients of the reference substances was similar for the two drop configurations studied. If this holds true over a wider range of configurations, such a ratio constitutes a valuable shortcut to the current practice of ignoring gas film resistance in the estimation of mass transfer rates.