bluuebunny/crossref_metadata_2025_split huggingface dataset:
Models for management of innovative activities on industrial enterprise
Authors: Volkova Violetta N. , Kudriavtceva Arina S. 
Published: August 2018

Innovations were the source of development of all spheres of life activities at all times. At present, the management of any organization is greatly influenced by the active development of innovative technologies of the third and fourth industrial revolutions. At the same time, innovative technologies can have both positive and negative effects. Therefore, when managing innovation activities of an enterprise, the requirements for thoroughness of their analysis are increased. It is necessary to make decisions about the expediency of choosing innovations for a particular enterprise (organization), taking into account the utility and consequences of implementation, to choose models that allow to take into account the specifics of a particular situation, the nature of innovations, their correspondence to the profile, resource and scientific and technical potential of the enterprise, market requirements, stages of the life cycle of the production technology, industries of the enterprise.The paper aims to substantiation of the models for management of innovative activity of the industrial enterprise.To realize the goal, a short analysis of modern technological innovations is carried out, recommended in the works of J. Rifkin [19, 20], K. Schwab [24] and the “Strategy of the Information Society Development in the Russian Federation for 2017–2030”. Based on this analysis, innovations are selected that can be used to develop a particular enterprise, and then models are proposed for more thorough evaluation and selection of innovations.The article briefly analyzes the technological innovations of the third and fourth industrial revolutions and suggests models for comparative analysis and selection of innovations.When developing models of analysis and selecting innovative technologies for specific enterprises and organizations, it is proposed to use methods of system analysis that are combined on the basis of an approach based on a step-by-step limitation of the domain of acceptable solutions and a gradual formalization of the model for selecting innovations.The analysis of innovative technologies and the proposed models are useful for the educational process of the university. The research was carried out on the example of the shipbuilding enterprise of Joint-Stock Company “Admiralteyskie Verfi”.
Management of Erectile Dysfunction: An Under-Recognition of Hypertension
Authors: Koroglu Gokhan , Kaya-Sezginer Ecem , Yilmaz-Oral Didem , Gur Serap 
Published: August 2018

Background:
Erectile dysfunction (ED) affects 30 million men in the US with a decrease in quality of
life. Thirty percent of hypertensive men suffer from ED.

Objective:
This review will debate the interplay between hypertension and ED, discovering novel insights
concerning hypertension-linked ED, as well as the influence of antihypertensive medications on patients with ED.

Method:
Total number of records screened from PubMed yielded by the search which performed from January
2000 - June 2018.

Results:
Hypertension can cause ED as a consequence of high blood pressure or antihypertensive treatment. Both
hypertension and ED have endothelial dysfunction as a common base mechanism, which can lead to an increase
in vascular smooth muscle contraction. Also, some phosphodiesterase (PDE)-5 inhibitors used to treat ED can
recover blood pressure.

Conclusion:
Understanding of common mechanisms involved in ED accompanied with hypertension and the
research on antihypertensive drugs that impact ED will bring important approaches for identifying novel therapeutic
strategies that will improve quality of life in patients with these conditions.
Phenolic Composition and Antifungal Effect of Costus cf. arabicus L Against Yeast of the Candida Genus
Authors: Dos Santos Antonia Thassya Lucas , Machado Antonio Júdson Targino , De Freitas Maria Audilene , De Menezes Irwin Rose Alencar , Coutinho Henrique Douglas Melo , Da Cunha Francisco Assis Bezerra , De Lima E Souza Djair Dos Santos , Boligon Aline Augusti , De Oliveira Adeliana Silva , De Alencar Silva Andressa , Morais-Braga Maria Flaviana Bezerra 
Published: August 2018

Background:
The emergence of fungal resistance to commercial drugs has been observed,
and because of that, research with natural products have been performed with the aim of
obtaining bioactive compounds.

Objective:
Evaluate the chemical composition and antifungal activity of the ethanolic extract of
Costus cf. arabicus L leaves (EECAL) over strains of the genus Candida, as well as its inhibitory
potential over yeast virulence.

Methods:
The composition of EECAL was analyzed through High Performance Liquid Chromatography
(HPLC). The Minimum Inhibitory Concentration (MIC) was determined by broth microdilution
using spectrophotometer readings and the Minimal Fungicidal Concentration (MFC) was investigated.
The reading data of the MIC was used to trace a cellular growth curve and calculate the
Inhibitory Concentration for 50% of the cells (IC50) of the extract and fluconazole. The effect over
the yeast morphology was verified using wet-chamber microculture and visualized through optical
microscopy (40x).

Results:
HPLC detected the presence of flavonoids and phenolic acids. The extract presented fungistatic
effect (MIC of 8.192 µg/mL). The IC50 of the extract and fluconazole varied between 4,008.7 to
5,116.8 µg/mL and 44.0 to 83.1 µg/mL, respectively. The extract inhibited the formation of hyphae
at MICx2 against CA LM 77. For the CA INCQS 40006, the inhibition was verified at MIC/2. In the
CT LM 23 and CT INCQS 40042 strains the presence of hyphae was considered absent at the MIC.

Conclusion:
The extract presented antifungal action on cell growth at elevated concentrations and
an inhibitory effect of dimorphism in the tested Candida species.
Synthesis, Antioxidant and Antiurease Activities of Some New 5,6- dichloro-2-(4-fluorobenzyl)-1H-benzimidazole Derivatives Containing Furan, Oxadiazole, Triazole and Thiadiazole Moieties
Authors: Bektas Hakan , Albay Canan , Menteşe Emre , Sokmen Bahar Bilgin , Kurt Zafer , Şen Dilem 
Published: August 2018

Background:Benzimidazoles and its derivatives have been attracting interest for many years because of their biological activities. Benzimidazoles containing different heterocyclic moieties have wide range of biological activities such as antimicrobial, antioxidant, anticancer, antiviral, etc.Methods:In this study, some benzimidazole derivatives containing furan, oxadiazole, triazole and thiadiazole moieties have been synthesized and then evaluated for their antioxidant and antiurease activities.Results:The results showed that all the tested benzimidazoles indicated remarkable urease inhibitory potentials with IC50 values ranging between 0.303±0.03 to 0.591±0.08 µM.Conclusion:In conclusion, synthesized benzimidazole derivatives showed good antioxidant and antiurease activities. Heterocyclic groups on benzimidazole nucleus enhance the activities.
An Integrated-OFFT Model for the Prediction of Protein Secondary Structure Class
Authors: Panda Bishnupriya , Majhi Babita , Thakur Abhimanyu 
Published: August 2018

Background:
Proteins are the utmost multi-purpose macromolecules, which play a crucial
function in many aspects of biological processes. For a long time, sequence arrangement of amino acid
has been utilized for the prediction of protein secondary structure. Besides, in major methods for the
prediction of protein secondary structure class, the impact of Gaussian noise on sequence representation
of amino acids has not been considered until now; which is one of the important constraints for the
functionality of a protein.
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Methods: In the present research, the prediction of protein secondary structure class was accomplished
by integrated application of Stockwell transformation and Amino Acid Composition (AAC), on equivalent
Electron-ion Interaction Potential (EIIP) representation of raw amino acid sequence. The introduced
method was evaluated by using 4 benchmark datasets of low sequence homology, namely PDB25, 498,
277, and 204. Furthermore, random forest algorithm together with the out-of-bag error estimate and
Support Vector Machine (SVM), using k-fold cross validation demonstrated high feature representation
potential of our reported approach.

Results:
The overall prediction accuracy for PDB25, 498, 277, and 204 datasets with randomforest classifier
was 92.5%, 94.79%, 92.45%, and 88.04% respectively, whereas with SVM, the results were
84.66%, 95.32%, 89.29%, and 84.37% respectively.

An integrated-order-function-frequency-time (OFFT) model has been proposed for the
prediction of protein secondary structure class. For the first time, we reported the effect of Gaussian
noise on the prediction accuracy of protein secondary structure class and proposed a robust integrated-
OFFT model, which is effectively noise resistant.
Quality by Design Based Method Development for Simultaneous Estimation of Montelukast Sodium and Theophylline in Tablet Dosage Form
Authors: Shah Kunti Abhishek , Parmar Vijaykumar Kunvarji 
Published: August 2018

Background:
Analytical Quality by design (AQbD) is one of the upcoming regulatory
requirements in the field of pharmaceutical analysis for the development of reliable and robust
analytical methods. Montelukast sodium and theophylline available in tablet dosage forms are used widely
for the treatment of airway disorders. Liquid chromatographic methods for estimation of the drugs are
reported but those chromatographic methods developed by the AQbD approach are not available.

Methods:
A systematic design of experiments has been employed to develop a liquid chromatographic
method for simultaneous estimation of montelukast sodium and theophylline. Critical process
parameters are defined and optimization of methanol content in mobile phase, the concentration of
trifluoroacetic acid and flow rate was employed within the framework of the full factorial design. The
statistical analysis of the experimental data for critical quality attributes namely tailing factor of both the
drugs and resolution was performed.

Results:
A multi-dimensional design space for the critical process parameters was obtained. The
optimal chromatographic separation of the two API was achieved using C18 (250mm×4.6mm, 5µm)
column as stationary phase and mobile phase composed of acetonitrile, trifluoroacetic acid (TFA)
(0.2%v/v in water) and methanol in the ratio of 25:15:60 (v/v/v) at flow rate of 1.0 ml min-1. The
influence of the CPP was evaluated by various data tables for example, analysis of variance and lack of
fit. Interpretation of various plots obtained from the experimental data such as predicted vs. actual,
predicted vs. run, pareto chart, perturbation plot and contour plot provided the information on the
manner in which each factor affects the critical quality attributes.

Conclusion:
A design space generated by design of experiments is an evidence for the robustness of the
method. The assay results show the applicability of the method for analysis of commercially available
tablets.
Effect of Neuroinflammation on ABC Transporters: Possible Contribution to Refractory Epilepsy
Authors: Deng Xiaolin , Xie Yangmei , Chen Yinghui 
Published: August 2018

Background & Objective: Epilepsy is a common and serious chronic neurological disorder
that is mainly treated with antiepileptic drugs. Although current antiepileptic drugs used in clinical
practice have advanced to the third generation, approximately one-third of patients are refractory to
these treatments. More efficacious treatments for refractory epilepsy are therefore needed. A better
understanding of the mechanism underlying refractory epilepsy is likely to facilitate the development
of a more effective therapy. The abnormal expression and/or dysfunction of efflux transporters, particularly
ABC transporters, might contribute to certain cases of refractory epilepsy. Inflammation in
the brain has recently been shown to regulate the expression and/or function of ABC transporters in
the cerebral vascular endothelial cells and glia of the blood-brain barrier by activating intracellular
signalling pathways.

Conclusion:
Therefore, in this review, we will briefly summarize recent research advances regarding
the possible role of neuroinflammation in regulating ABC transporter expression in epilepsy.
Kumaraswamy Distribution and Random Extrema
Authors: Kozubowski Tomasz J. , Podgórski Krzysztof 
Published: August 2018

Objective:We provide a new stochastic representation for a Kumaraswamy random variable with arbitrary non-negative parameters. The representation is in terms of maxima and minima of independent distributed standard uniform components and extends a similar representation for integer-valued parameters.Result:The result is further extended for generalized classes of distributions obtained from a “base” distribution functionFviz.G(x) =H(F(x)), whereHis the CDF of Kumaraswamy distribution.
Kinetic Behaviour of Skin Pigmentation Inhibitory Activity of some Selected Nigerian Medicinal Plants and Other Related Antioxidant Properties
Authors: Popoola Olugbenga K. , Faleye Francis J. , Olabiyi Folorunso A. , Ayodele Olajide 
Published: August 2018

Background:
Over exposure to Ultra Violet (UV) radiation is one of the most significant
external stress-inducing factors resulting into occurrence of skin pigmentation among others in human
body. The biological implication of such disorders is not only limited to premature skin aging
and cancer, but also resulted into economic loss of perishable agricultural products.

Methods:
Methanol extracts of ten (10) medicinal plants with skin health traditional history were selected
for this study. The biological profile of the extracts was assessed in an in-vitro system using
colorimetric assays: tyrosinase inhibition, Ferric-ion Reducing Antioxidant Power (FRAP), Trolox
Equivalent Absorbance Capacity (TEAC) and Fe II-induced microsomal lipid peroxidation.

Results:
Representative of asteraceae such as Laggera pterodonta (S3); Ageratum conyzoides (S4)
and Chromolaena odorata (S5), while Euphorbia convoluloides (S8) were found to possess good anti-
tyrosinase activity (IC50 = 177.50; 125.08; 167.58; 161.92) μg/ml respectively, in which the rate of
formation of dopachrome proceeded via pseudo second order kinetic using the Largergren model.
Other notable inhibition of oxidative stress displayed by the methanol extracts includes S7 (FRAP =
1905.12 ± 2.85 µM AAE/g); S1 & S6 (TEAC = 2163.48 ± 2.80; 1044.35 ± 28.99) µM TE/g, while
S7 & S9 showed highest inhibitory activities on Fe II-induced microsomal lipid peroxidation (IC50 =
33.625; 35.125) µg/ml, respectively in competitive manner to that of the commercial anti-oxidant
EGCG (IC50 = 36.250 µg/ml).

Conclusion:
The outcome of the biological properties of the selected plant extracts in this study
suggested the existence of relationship between the traditional claims and the scientific data therein.
LoWVR: Low Overhead Watermark based Vehicle Revocation Scheme in VANET
Authors: Mondal Atanu , Mitra Sulata 
Published: August 2018

Background and Objective:
The inter-vehicle communication is a potential issue for improving
road safety, detecting traffic accidents, etc. in vehicular ad hoc network. The communication
among the vehicles in VANET must be protected from the dissemination of message by unauthorized
vehicles and the alteration of the message by misbehaving vehicles.

Methods:
In this paper, a low overhead digital watermark based vehicle revocation scheme is proposed.
The sender vehicle generates a message and a random number after observing an event. It generates
a deformed version of the generated message and message digest, and concatenates them. The
watermark bits are generated by the sender vehicle from its unique identification and the random
number. The sender vehicle embeds the watermark bits in the concatenated form of the message digest
and deformed version of the generated message, and broadcasts the embedded message for its
neighbours. The neighbour vehicles extract the required information from the received embedded
message to verify the authentication of the sender vehicle and to identify whether the sender vehicle is
an alteration attacker. It revokes unauthentic vehicles and vehicles that are identified as alteration attacker
from vehicular ad-hoc network without any dependency on the trusted third party. The cracking
probability and cracking time are used to measure the robustness of the scheme. The cracking probability
and cracking time are measured to set the design guideline regarding the size of the watermark.
The qualitative performance of the scheme is measured in terms of storage, communication and computation
overhead. The significant reduction of all such overheads is observed by comparing the qualitative
performance of the proposed scheme with two existing schemes.

Conclusion and Results:
Thus, the proposed scheme is a low overhead solution of securing vehicular
ad hoc network. Performance of the scheme is also studied quantitatively in terms of the time of verifying
vehicle authentication at the receiving end, delay in message dissemination at the sending end
and delay in message reception at the receiving end. The quantitative performance is also compared
with two of the existing schemes.
Morphological dimorphism varies across the endemic Xantus’ hummingbird (Hylocharis xantusii) genetic populations in the Baja California Peninsula
Authors: González-Rubio Sanvicente Cristina , García-de León Francisco J. , Rodríguez-Estrella Ricardo 
Published: August 2018

Morphological dimorphism traits play an important role in our understanding of species evolution. In birds, sexual dimorphism occurs in a number of characteristics, such as body and shape size, wing and bill morphology. Hylocharis xantusii is the only hummingbird species endemic to the Baja California Peninsula, Mexico that has adapted to xeric conditions, associated to oases regions, and displays a sexual dimorphism on color pattern. We quantified morphological variation between males and females to determine whether morphological traits have a significant contribution to sexual dimorphism, and we analyzed if differences in morphological patterns among genetic populations of Xantus’ hummingbird existed. A morphological dimorphism was found in four of six traits analyzed, males were bigger in size (total length) with larger wings (wing chord and tail length) and wider bills (bill width). Differences in morphological traits of genetic populations were found. Individuals of southern population were in average smaller than central and northern populations while individuals from central populations had larger bills and wing chords. Northern populations had longer tails and wider bills. The results indicated that populations and sex are independent to morphological differences in Xantus’ hummingbird. The best fitted GLM shows that the altitude and oasis location related to the genetic population correctly explains the differences in tail, wing chord and bill width traits of hummingbirds along the Baja California Peninsula. We suggest that local conditions related to environmental heterogeneity and oases distribution are promoting levels of morphological differentiation. Genetic populations were already known to be result of their evolutionary history, of the phylogeographic pattern. Sexual dimorphism on morphological traits observed in H. xantusii is related in first place to ecological differences among oases, and second, related to mating and social behavior.
Composición de la dieta de Sceloporus horridus horridus (Sauria: Phrynosomatidae) en bosque tropical caducifolio, México
Authors: Castro-Franco Rubén , Bustos-Zagal María Guadalupe , Trujillo-Jiménez Patricia 
Published: August 2018

Se estudió la composición de la dieta de una población de lagartijas de Sceloporus horridus horridus del centro de Morelos, México. Se analizó la diversidad del alimento, la variación entre las estaciones húmeda y seca del año, y el traslape de la dieta entre hembras y machos. Los datos fueron comparados con los de otras poblaciones de Jalisco y Puebla, México. La dieta estuvo formada por 18 grupos de insectos, donde destacan por su valor de importancia los coleópteros (69.3%), hemípteros (68.0%), formícidos (38.7%) y larvas (37.3%). Hubo variación en la frecuencia de ocurrencia y en el porcentaje de consumo de alimento entre los periodos de lluvias y secas. Un ANOVA para comparar la dieta entre hembras (H´ = 2.14) y machos (H´ = 2.08) mostró diferencias significativas entre los dos sexos. Se concluye que en lo general la dieta de la población estudiada es similar a la observada en otras poblaciones de esta especie.
Una nueva especie del género Guillarmodia (Mollusca: Gastropoda: Pulmonata: Spiraxidae) del noreste de México
Authors: Correa-Sandoval Alfonso , Barrientos-Lozano Ludivina , Strenth Ned E. 
Published: August 2018

Un nuevo caracol terrestre, Guillarmodia (Guillarmodia) marcelae n. sp. Correa-Sandoval, Barrientos -Lozano & Strenth es descrita para las montañas de la Sierra Los Soldados, región del estado de Tamaulipas en el noreste de México. Esta nueva especie difiere de otras especies regionales de Guillarmodia por su tamaño pequeño y distintivas estriaciones subsuturales. Se incluye información del hábitat de la especie y de la distribución geográfica de especies relacionadas
Uso de microhábitats, actividad diaria y dieta de Dendrobates truncatus (cope, 1861) (Anura: Dendrobatidae) en bosque seco tropical del norte de Colombia
Authors: Posso-Peláez Carolina , Blanco-Torres Argelina , Gutiérrez-Moreno Luis C. 
Published: August 2018

Se estudió el uso de microhábitats, actividad diaria y dieta de tres poblaciones de Dendrobates truncatus en el bosque seco tropical de tierras bajas del Caribe colombiano, mediante la utilización del método de encuentro visual y captura manual. El estudio se realizó entre los meses de marzo y noviembre, durante los tres períodos climáticos del año: seco, lluvias menores y lluvias mayores. Se identificaron y muestrearon siete microhábitats usados por esta especie, la actividad se midió a través de la relación número de individuos/hora en cuatro horarios diarios. Se examinaron los contenidos estomacales de los anuros y se aplicó el método de análisis porcentual. D. truncatus presenta mayor actividad en la mañana (8:00 – 10:00) y final de la tarde (16:00 – 18:00) y usa siete tipos de microhábitats, preferentemente los de cobertura boscosa y con altos valores de humedad. Presenta preferencia marcada por el consumo de hormigas, especialmente la familia Myrmicinae y el género Pheidole. Estos resultados sugieren que la conservación de relictos de bosque seco tropical y el desarrollo de estrategias de rehabilitación del mismo se constituyen en elementos fundamentales para la supervivencia de esta especie.