bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prolonged diabetic ketoacidosis associated with canagliflozin
Authors: Sloan Gordon , Kakoudaki Tania , Ranjan Nishant 
Published: June 2018

Summary
We report a case of a 63-year-old man who developed diabetic ketoacidosis (DKA) associated with canagliflozin, a sodium glucose co-transporter 2 (SGLT-2) inhibitor. He presented acutely unwell with a silent myocardial infarction, diverticulitis and DKA with a minimally raised blood glucose level. Standard therapy for DKA was initiated. Despite this, ketonaemia persisted for a total of 12 days after discontinuation of canagliflozin. Glucosuria lasting for several days despite discontinuation of the medications is a recognised phenomenon. However, this is the longest duration of ketonaemia to be reported. The cause of prolonged SGLT-2 inhibition remains uncertain. Deviation from the normal DKA treatment protocol and use of personalised regimens may be required in order to prevent relapse into ketoacidosis while avoiding hypoglycaemia in those that develop this condition.

Learning points:

Diabetic ketoacidosis (DKA) may develop in the presence of lower-than-expected blood glucose levels in patients treated with a sodium glucose co-transporter 2 (SGLT-2) inhibitor.

Certain individuals prescribed with SGLT-2 inhibitors may be more at risk of DKA, for example, those with a low beta cell function reserve, excessive alcohol consumption and a low carbohydrate diet.

In order to reduce the risk of SGLT-2 inhibitor-associated DKA, all patients must be carefully selected before prescription of the medication and appropriately educated.

Increased serum ketone levels and glucosuria have been reported to persist for several days despite discontinuation of their SGLT-2 inhibitor.

Physicians should consider individualised treatment regimens for subjects with prolonged DKA in the presence of SGLT-2 inhibition.
False-positive findings on 6-[18F]fluor-l-3,4-dihydroxyphenylalanine PET (18F-FDOPA-PET) performed for imaging of neuroendocrine tumors
Authors: Berends Annika M A , Kerstens Michiel N , Bolt Janne W , Links Thera P , Korpershoek Esther , de Krijger Ronald R , Walenkamp Annemiek M E , Noordzij Walter , van Etten Boudewijn , Kats-Ugurlu Gursah , Brouwers Adrienne H , van der Horst-Schrivers Anouk N A 
Published: June 2018

Background/aimPET with 6-[18F]fluor-l-3,4-dihydroxyphenylalanine (18F-FDOPA) has been shown to be a useful imaging tool with a high sensitivity for the visualization of neuroendocrine tumors (NETs).18F-FDOPA uptake in tumors other than NETs has been suggested previously, but data on this phenomenon are limited. We therefore studied the non-physiological, false-positive uptake of18F-FDOPA in a large population of patients with a NET or with a high clinical suspicion of harboring a NET.Patients and methodsRetrospective single-center study among adult patients in whom18F-FDOPA PET scintigraphy was performed between January 2004 and December 2014. The original scan report was compared with the original pathology report corresponding with the18F-FDOPA PET-positive lesion. In case this was inconsistent with the diagnosis of a NET, both the scan and the pathology slides were reassessed. Specimens of these non-NET tissues were immunohistochemically stained for AADC.Results107018F-FDOPA PET scans from 705 patients were evaluated. Focal or multiple18F-FDOPA-avid lesions were described in 70918F-FDOPA PET scans (66%). Histology of these18F-FDOPA PET-positive lesions was present in 508 (72%) cases. In seven cases, the histopathology was not compatible with NET but showed squamous cell carcinoma of the cervix, multiple myeloma (two cases), hepatocellular carcinoma, Schwannoma, adrenocortical carcinoma and a skeletal myxoid chondrosarcoma, with positive immunohistochemical staining for AADC in 67%.ConclusionsPathological uptake of18F-FDOPA does not always indicate the presence of a NET. The possibility of18F-FDOPA uptake by tumor types other than NETs, although rare, should be considered.
Association of metabolic syndrome and level of hs-CRP, Lp(a), and serum ferritin in young Asian patients (≤45 years) with acute myocardial infarction
Authors: Ramesh Gadepalli , Sai Nyayapathi Venkata Balakrishna , Gururaj Pramod , Bhupal Reddy , Patel Nilesh 
Published: June 2018

Aims
This study was aimed to determine the levels of hs-CRP, serum ferritin, and Lp(a) and to study the prevalence of metabolic syndrome (MetS) in young patients (≤45 years) with and without acute myocardial infarction (AMI).

Methods
This was a cross-sectional, case–control study conducted at a tertiary care center in India. Equal number of patients with matched age and sex (n = 51) were included in case group (with AMI) and in control group (without AMI). Subjects were assessed for the presence of MetS as per modified ATP III criteria. The hs-CRP, Lp(a), and serum ferritin were also measured.

Results
The prevalence of MetS was found to be 62.74% in case group, whereas 33.33% in control group with decreased HDL level as the most prevalent parameter. The hs-CRP level was found to be 15.35 ± 8.27 mg/dl in case group and 1.85 ± 1.05 mg/dl in control group and Lp(a) was 33.84 ± 23.69 mg/dl in case group and 19.68 ± 10.39 mg/dl in control group. No significant difference was observed in the serum ferritin level in case (264.2 ± 40.6 ng/dl) and control (225.51 ± 45.35 ng/dl) groups.

Conclusion
From this study, we can conclude that the assessment of these novel risk factors [hs-CRP, Lp(a), and MetS] may be used for the risk estimation and can help to prevent future mortality and morbidity due to CVD.
İLK DEFA ETKİLEŞİMLİ TAHTA KULLANAN ÖĞRETMENLERİN ALGILARININ İNCELENMESİ
Authors: ALTUN Taner , GÜLAY Ahmet , SİYAMBAŞ MAZLUM Pembe Başak 
Published: June 2018

Nitel yaklaşıma sahip olan bu durum çalışmasında, ilk defa
etkileşimli tahta kullanılan bir okuldaki öğretmenlerin buna ilişkin
algılarının belirlenmesi amaçlanmıştır. Araştırmanın çalışma grubunu, Rize ilinde
bir okulda çalışan yedisi sınıf ve yedisi branş olmak üzere toplam on dört
öğretmen oluşturmuştur. Veriler, yarı yapılandırılmış görüşme tekniği ile
toplanmıştır. Elde edilen veriler temel düzey ve içerik analizi ile analiz
edilmiştir. Araştırma sonucunda etkileşimli tahta kullanımına ilişkin
öğretmenlerin yarısının görüşünün olumlu ve diğer yarısının olumsuz olduğu
belirlenmiştir. Araştırmada öğretmenlerin etkileşimli tahta kullanımına ilişkin
hizmet içi eğitimi yetersiz buldukları görülmüştür. Araştırmada katılımcıların
büyük bölümünün öğrenme sürecinde etkileşimli tahta kullanımına devam edilmesi
beklentisinde oldukları belirlenmiştir. Araştırma sonuçlarına dayalı olarak
etkileşimli tahtaya ilişkin alt yapının bir an önce tamamlanması, etkileşimli
tahta kullanımına yönelik hizmet içi eğitimlerin süre ve uygulama yönünden
geliştirilmesi, öğrenme sürecinde etkileşimli tahta kullanırken önceden gerekli
hazırlık ve planlamanın yapılması önerilerinde bulunulmuştur.
İLAHİYAT FAKÜLTESİ ÖĞRENCİLERİNİN YAZ OKULUYLA İLGİLİ GÖRÜŞLERİ (AİBU İLAHİYAT FAKÜLTESİ ÖRNEĞİ)
Authors: ÖZ Ayhan , SANCAK Seyid 
Published: June 2018

Bu çalışmanın amacı İlahiyat
Fakültesi öğrencilerinin üniversitelerimizde gittikçe yaygınlaşan yaz
okullarından ders almalarının temel sebeplerini ve bu uygulamayla ilgili
görüşlerini tespit etmektir. Araştırmada nicel tarama modeli kullanılmış,
veriler betimsel ve ilişkisel analize tabi tutulmuştur. Sonuçta öğrencilerin
yaz okulunda ders almalarının temel sebebinin son sınıf ders yoğunluğu azaltmak
ve alttan kalan dersleri vermek olduğu, yaz okulunu bir fırsat olarak
gördükleri ve kaldırılmasına sıcak bakmadıkları tespit edilmiştir. Bununla
birlikte yaz okulunda güz ve yaz dönemindeki motivasyonu bulmakta
zorlandıkları, yazın ders almaktan sıkıldıkları, yaz okulunun verimliliği
noktasında da kafaların kısmen karışık olduğu gözlenmiştir. Ayrıca yaz okulunun
öğrencilerde kolay ders geçme ve kolay yüksek not alma hususlarında kısmi bir
beklenti oluşturduğu ve bu beklentinin erkek öğrencilerde kız öğrencilere göre
anlamlı düzeyde daha yüksek olduğu da tespit edilmiştir. Yaz okulunun devam
etmesinin öğrenci için faydalı bir uygulama olduğu, ancak derslerin
verimliliğini ve öğrenci motivasyonunu arttırmak için öğrenciyi aktif kılacak
bir sürecin işletilmesinin gerekliliği değerlendirilmiştir.

&nbsp;
ÖĞRETMEN ADAYLARININ KİŞİSEL KARARSIZLIK VE ELEŞTİREL DÜŞÜNME MOTİVASYONLARI
Authors: TUNCEL Meriç , YILDIZ Sevilay , YILDIZ Kaya , YAVUZ Ramazan 
Published: June 2018

Bu
araştırmanın temel amacı, öğretmen adaylarının
kişisel kararsızlık düzeyleri ile eleştirel düşünme motivasyonlarını tespit
etmek ve öğretmen adaylarının kişisel kararsızlık düzeyleri ile eleştirel
düşünme motivasyonları arasında ilişki olup olmadığını belirlemektir. Araştırmada ilişkisel
tarama modellerinden açıklayıcı ilişkisel desen kullanılmıştır. Araştırmanın çalışma grubunu, Türkiye’nin Kuzey Batısında
bulunan bir üniversitenin Eğitim Fakültesi 2016-2017 akademik yılı güz
döneminde öğrenim gören 417 son sınıf öğretmen adayı oluşturmuştur. Araştırmada
şu sonuçlara ulaşılmıştır. Araştırmaya dahil olan öğretmen adaylarının karar alırken
araştırma yaptıkları ve aceleci davranmadıkları;
eleştirel düşünme motivasyonları beklenti, değer/yararlılık ve değer/bedel alt
boyutlarında “katılıyorum”; değer, değer/başarı ve değer/içsel değer-ilgi
değeri “kesinlikle katılıyorum” seçeneklerinde yığılma göstermektedir. Kişisel
Kararsızlık Ölçeği’nin aceleci karasızlık alt boyutu ile Eleştirel Düşünme
Motivasyonu Ölçeği’nin değer ve değer/yararlılık alt boyutları arasında negatif
orta düzeyde anlamlı; diğer alt boyutları arasında yine negatif düşük düzeyde
anlamlı ilişki görülmektedir.

&nbsp;
BİYOLOJİ ÖĞRETMEN DÖNÜTLERİNİN BİÇİMLENDİRMEYE YÖNELİK ÖLÇME DEĞERLENDİRME AÇISINDAN İNCELENMESİ
Authors: BAYRAK Naci , DOĞAN Salih 
Published: June 2018

Bu çalışmanın amacı; biyoloji
öğretmenlerinin öğrencilerine verdikleri sözlü ve yazılı dönütleri
biçimlendirmeye yönelik ölçme değerlendirme açısından tip ve nitelik olarak
incelemektir. Bu amaçla Erzurum ilinde görev yapan 32 biyoloji öğretmeni ile
yürütülen çalışmada veriler nitel araştırma yaklaşımı çerçevesinde görüşme
yöntemi ile toplamıştır. Toplanan verilerden dönüt tiplerini ve niteliğinin
belirlenmesinde içerik analizi kullanılmıştır. Araştırma bulguları
öğretmenlerin daha çok değerlendirici dönütü kullandıklarını, betimleyici
dönütü etkin bir şekilde kullanmadıklarını, dönütlerinde öğrencilerine hataları
ve giderme yolları hakkında bilgi sunma konusunda problem yaşadıklarını, akran
değerlendirmesi gibi öğrencilerin birbirini değerlendirip dönüt verecekleri
yöntemleri pek tercih edemediklerini göstermiştir. Bu sorunların en önemli
nedeni öğretmenlerin betimleyici dönütlerle ilgili yeterli bilgi sahibi
olmamaları olarak değerlendirilmektedir. Çalışmanın sonunda öğretmenlerin dönüt
kullanımı konusunda bilgi, beceri ve yeterliliklerini artırması yönünde
önerilerde bulunulmuştur.
Do We Appear to Be a Profession Chasing Its Tail? Non-Social Work Major Perceptions
Authors: Zosky Diane 
Published: June 2018

The profession of social work has recently completed its centennial celebration, yet it still remains a profession with an identity struggle. Could the internal struggles experienced within the profession have a negative effect on young people who are selecting career pursuits? An investigation was undertaken at a medium-sized university assessing the perceptions held by non-social-work majors about the social work profession and the social work major.
Results demonstrated that the social work major was perceived to be as difficult as other majors and social work students were perceived to be as intelligent as other students. Social work careers were perceived to be more challenging than other occupations. The results highlighted some confusion regarding intensity of the curricular requirements for social work and the difference between social work and sociology or psychology. The struggle for professional identity did not seem to negatively affect perceptions regarding social work for this sample of students.
Comparison of laboratory and imaging methods associated with bone metabolism in patients with or without renal failure under the age of 45 years with elevated parathyroid hormone levels
Authors: PEYNİRCİ Hande , ERSOY Canan , GÜRSOY Vildan , GİRGİN Ayten , AŞIK Mehmet Ali , GÜLTEPE Ahmet , ÖZKAYA Güven , ISIKTAS SAYILAR Emel , ERSOY Alpaslan 
Published: June 2018

Objectives: Although bone biopsy is
considered the gold standard for the definitive diagnosis of renal
osteodystrophy; it is not suitable for routine clinical practice due to its
invasive nature. The present
study was aimed to evaluate and compare the
bone mineral status using dual energy
X-ray absorptiometry of patients with
or without chronic kidney disease in young population with elevated parathyroid hormone
levels. Methods: This was a single center, cross-sectional,
retrospective study conducted in patients younger than 45 years of age. The study was performed in the outpatient clinic of a
university hospital. Patients
with elevated parathyroid hormone levels were included. Results: Among them, 29 had renal insufficiency, 158 had normal
renal function. Measured bone mineral
density with dual energy X-ray absorptiometry
and laboratory values were collected from patient files. The primary end point was to assess the efficiacy of dual
energy X-ray absorptiometry in patients with or without renal failure. Except
Z score at Ward’s triangle, all of the T and Z scores at lomber, femur neck, trochanteric, and
intertrochanteric areas were found significantly lower in
patients with chronic kidney disease compared to those without
(p &lt; 0.001).
Conclusion: Dual energy X-ray absorptiometry seemed to be a
reliable method for detection of osteoporosis in premenopausal female and male
patients younger than 45 years of age with or without renal
failure with elevated parathyroid hormone levels.
PANDANGAN ISLAM TENTANG KEDUDUKAN HAM BAGI NON MUSLIM: Pendekatan Fiqh Politik
Authors: Muzakki Akhmad 
Published: June 2018

<p>The concept of human rights is the result of cultural ingredients that are not based on the principle of religion, so it is anthropocentric, that is focused only on the human itself. Even in the secular West's view, human rights are the expression of human freedom irrespective of God's provisions, religion, morals or metaphysical obligations. In contrast to the Islamic view, that human rights and even human beings are God's grace and will come back later. Based on this, human rights in Islam are theocentric, that is aimed at and sourced from God. Islam places human rights as a consequence of the obligation to God. Externally, the Islamic state is totally separate from other non-Islamic communities. Internally, the Islamic state is an ummah and a group of people united with one another by the ties of Islamic (Islamic) equality. States can not impose restrictive measures and diminish their rights altogether.</p><p> </p><p>Konsep HAM adalah hasil ramuan budaya yang tidak berpijak pada prinsip agama, maka ia bersifat antroposentris, yakni terfokus hanya pada manusia itu sendiri. Bahkan dalam pandangan Barat sekuler, HAM adalah ekspresi kebebasan manusia yang terlepas dari ketentuan Tuhan, agama, moral atau kewajiban metafisika. Berbeda dengan pandangan Islam, bahwa HAM bahkan wujud manusia sekalipun adalah anugerah Tuhan dan kepada-Nya kelak akan kembali. Berdasarkan ini, HAM dalam Islam bersifat teosentris, yakni bertujuan untuk dan bersumber dari Tuhan. Islam menempatkan HAM sebagai kosekuensi dari pelaksanaan kewajiban terhadap Allah. Secara eksternal, negara Islam sama sekali terpisah dari komunitas lain bukan Islam. Secara internal, negara Islam adalah suatu ummah dan sekumpulan orang-orang yang dipersatukan antara satu dengan yang lain oleh ikatan persamaan agama { Islam ). Negara tidak dapat mengadakan tindakan pembatasan dan pengurangan hak-hak mereka walau sedikitpun.</p><p> </p><p> </p>
PERAN PERGURUAN TINGGI AGAMA ISLAM NEGERI (PTAIN) DALAM MEMASUKI ERA KOMPETISI GLOBAL
Authors: Ghofir Abdul 
Published: June 2018

<p>Along the time, it seems the mission of this da'wah is no longer can be maintained, because it is not in accordance with the development and current demands. Besides, the mission of dakwah does not has a significant meaning to the surrounding community. That is, with the existence of IAIN (with its branch faculty) circumstances on the surrounding community does not necessarily become more qualified, either social, moral and spiritual. Even in some areas, existence of IAIN does not provide significant resonance to the community. The presence and absence of IAIN, has no impact directly or indirectly to the public. On the contrary, some areas where there is no IAIN might have a better condition morally and spiritually.</p><p> </p><p>Seiring dengan perjalanan waktu, nampaknya misi dakwah ini tidak lagi bisa dipertahankan, karena tidak sesuai dengan perkembangan dan tuntutan jaman. Disamping juga, misi dakwah ini temyata tidak mempunyai makna yang signifikan kepada masyarakat sekitar. Artinya, dengan keberadaan IAIN (dengan fakultas cabangnya) keadaan secara masyarakat sekitar tidak serta merta menjadi lebih berkualitas, baik sosial, moral dan spiritual. Bahkan di beberapa daerah, keberadaan IAIN tidak memberikan resonansi yang signifikan terhadap masyarakat sek:itamya. Ada dan tidak adanya IAIN, tidak memberikan dampak langsung maupun tidak langsung terbadap masyarakat Demikian juga sebaliknya, beberapa daerah yang kebetulan tidak ditempati IAIN (fakultas cabangnya) bukan berarti secara moral dan spiritual lebih jelek dari yang ditempati IAIN.</p>
Los impresos poblanos efímeros. Una mirada a “Tertulia de pulquería”, de José A. Arrieta, 1851
Authors: Rojas Rendón María José Patricia 
Published: June 2018

<p>La pintura con escenas costumbristas realizada por José Agustín Arrieta no se limitó a mostrar una mirada documental. “Tertulia de pulquería” se presenta como ejemplo de una construcción visual, que abre la posibilidad de ser entendida a través del proceso habitual de mirar a “la clase peligrosa”. El presente artículo analizará el cuadro de Arrieta a partir de un recurso significativo: la prensa efímera e “inmoral” poblana de 1851 –representada en el cuadro- y la forma en que se vinculó con el sector “peligroso”. El trabajo propondrá una lectura política y social de “Tertulia de pulquería” que permita conocer las circunstancias donde el pintor ejecutó la obra. Las hojas impresas representadas son elementos fundamentales que proponen una visión negativa en la que el artista tomó distancia y denunció un malestar vivido en el año 1851 en Puebla. Este estudio pone énfasis en la importancia de la búsqueda y el análisis de las fuentes primarias obtenidas en los archivos y hemerotecas locales.</p>
Costal Osteochondral Autograft for Advanced Osteochondritis Dissecans of the Humeral Capitellum in Adolescent and Young Adult Athletes
Authors: Sato Kazuki , Iwamoto Takuji , Matsumura Noboru , Suzuki Taku , Nishiwaki Yuji , Oka Yoshinori , Nakamura Toshiyasu 
Published: June 2018

Background:
Costal osteochondral grafting is a technique to achieve anatomical and biological repair of articular defects. Some small series of clinical applications of this procedure for advanced osteochondritis dissecans of the humeral capitellum, with short-term follow-up, have been reported; however, longer-term outcomes remain unclear. The purpose of this study was to clarify longer-term clinical outcomes of costal osteochondral autografts in the treatment of advanced osteochondritis dissecans of the humeral capitellum.

Methods:
Seventy-two patients with an osteochondral defect of the humeral capitellum were treated with costal osteochondral autograft and followed for a minimum of 3 years (mean follow-up, 57 months; range, 36 to 147 months). The mean patient age was 14.3 years. Clinical outcomes, including elbow range of motion, Timmerman and Andrews clinical rating score, donor-site morbidity, responses to a questionnaire regarding a return to sporting activities, and radiographic findings, were evaluated.

Results:
The mean elbow range of extension/flexion increased significantly, from −21°/122° preoperatively to −4°/136° postoperatively (p < 0.001). The mean clinical rating score improved significantly, from 101 to 190 by the latest follow-up (p < 0.001). The overall clinical score-based assessment was excellent for 60 patients, good for 9, and fair for 3. Seventy of the 72 patients returned to their original sport. The remaining 2 patients had changed sporting activities before surgery and did not return to baseball, despite satisfactory clinical results.

Conclusions:
Costal osteochondral autograft successfully achieved anatomical and biological reconstruction in the treatment of advanced osteochondritis dissecans of the humeral capitellum.

Level of Evidence:
Therapeutic Level IV. See Instructions for Authors for a complete description of levels of evidence.
Vancomycin-Loaded Polymethylmethacrylate Spacers Fail to Eradicate Periprosthetic Joint Infection in a Clinically Representative Mouse Model
Authors: Carli Alberto V. , Bhimani Samrath , Yang Xu , de Mesy Bentley Karen L. , Ross F. Patrick , Bostrom Mathias P.G. 
Published: June 2018

Background:Periprosthetic joint infection (PJI) remains a devastating complication following total joint arthroplasty. Current animal models of PJI do not effectively recreate the clinical condition and thus provide limited help in understanding why treatments fail. We developed a mouse model of the first-stage surgery of a 2-stage revision for PJI involving a 3-dimensionally printed Ti-6Al-4V implant and a mouse-sized cement spacer that elutes vancomycin.Methods:Vancomycin was mixed with polymethylmethacrylate (PMMA) cement and inserted into custom-made mouse-sized spacer molds. Twenty C57BL/6 mice received a proximal tibial implant and an intra-articular injection of 3 × 105colony-forming units ofStaphylococcus aureusXen36. At 2 weeks, 9 mice underwent irrigation and debridement of the leg with revision of the implant to an articulating vancomycin-loaded PMMA spacer. Postoperatively, mice underwent radiography and serum inflammatory-marker measurements. Following euthanasia of the mice at 6 weeks, bone and soft tissues were homogenized to quantify bacteria within periprosthetic tissues. Implants and articulating spacers were either sonicated to quantify adherent bacteria or examined under scanning electron microscopy (SEM) to characterize the biofilm.Results:Vancomycin-loaded PMMA spacers eluted vancomycin for ≤144 hours and retained antimicrobial activity. Control mice had elevated levels of inflammatory markers, radiographic evidence of septic loosening of the implant, and osseous destruction. Mice treated with a vancomycin-loaded PMMA spacer had significantly lower levels of inflammatory markers (p < 0.01), preserved tibial bone, and no intra-articular purulence. Retrieved vancomycin-loaded spacers exhibited significantly lower bacterial counts compared with implants (p < 0.001). However, bacterial counts in periprosthetic tissue did not significantly differ between the groups. SEM identifiedS. aureusencased within biofilm on control implants, while vancomycin-loaded spacers contained no bacteria.Conclusions:This animal model is a clinically representative model of PJI treatment. The results suggest that the antimicrobial effects of PMMA spacers are tightly confined to the articular space and must be utilized in conjunction with thorough tissue debridement and systemic antibiotics.Clinical Relevance:These data provide what we believe to be the first insight into the effect of antibiotic-loaded cement spacers in a clinically relevant animal model and justify the adjunctive use of intravenous antibiotics when performing a 2-stage revision for PJI.