bluuebunny/crossref_metadata_2025_split huggingface dataset:
Gossypetin Inhibits Solar-UV Induced Cutaneous Basal Cell Carcinoma Through Direct Inhibiting PBK/TOPK Protein Kinase
Authors: Wang Lijuan , Zhang Zixi , Ge Rui , Zhang Jian , Liu Wenli , Mou Kuanhou , Lv Shemin , Mu Xin 
Published: March 2019

Background:Skin photoaging, skin inflammation and skin cancer are related with excessive exposure to solar UV. PDZ-binding kinase/T-LAK cell-originated protein kinase (PBK/TOPK), a member of the serine/threonine protein kinase, which regulates the signaling cascades of p38 mitogen-activated protein kinase (p38 MAPK) and extracellular signal regulated kinase 1/2 (ERK1/2). PBK/TOPK plays a significant role in solar-UV-induced cutaneous basal cell carcinoma (BCC), and targeting PBK/TOPK can be supposed to treat and prevent cutaneous BCC.Methods:The pathological feature and the expression level of PBK/TOPK in cutaneous BCC tissues of human were studied in clinical samples. SUV-induced the phosphorylation of p38 MAPK and ERK1/2 were demonstrated ex vivo. Moreover, the interaction between Gossypetin and PBK/TOPK were detected by in vitro kinase assay and Microscale thermophoresis (MST) assay. Furthermore, the effect of Gossypetin to solar UV-induced the activity of PBK/TOPK were detected ex vivo and in vivo.Results:The clinical samples showed that the expression levels of PBK/TOPK, phosphor-p38 MAPK and phosphor- ERK1/2 were up-regulated in cutaneous BCC tissues of human. The expression of phosphor-p38 MAPK or phosphor-ERK1/2 increased in a dose and time dependent manner after solar UV treatment in HaCaT cells. MTT cytotoxicity assay results showed that Gossypetin has no effect on HaCaT cells. In vitro kinase assay and MST assay results showed that Gossypetin bound with PBK/TOPK and suppressed PBK/TOPK activity. Ex vivo results showed Gossypetin inhibited solar UV-induced phosphorylation of PBK/TOPK, p38 MAPK, ERK1/2 and H2AX by suppressing PBK/TOPK activity. In vivo test results indicated that Gossypetin suppressed solar UV-induced increase of PBK/TOPK, phosphor-p38 MAPK, phosphor-ERK1/2 and phosphor- H2AX in SKH-1 hairless mice.Conclusion:Our data demonstrated that Gossypetin can alleviate solar-UV-induced cutaneous BCC by blocking PBK/TOPK, and Gossypetin could be a remarkable agent for treating solar-UV induced cutaneous basal cell carcinoma.
Manifestations in the Oral Mucosa of Erythromelalgia. A Case Report
Authors: López-Valverde Nansi , López-Valverde Antonio , Ramírez Juan M , Gómez de Diego Rafael 
Published: March 2019

Introduction:Erythromelalgia or erythermalgia, is a peripheral paroxysmal vascular disease of the distal extremities, although it can also affect the face, ears and knees. It is characterized by increased skin temperature, erythema and intermittent episodes of burning pain. Likewise, it can also be characterized by lesions of the oral mucosa.Case report:Here we present the case of a 6-year old female with EM presenting ulcerative and scaly lesions in the oral cavity and whitish linear branching ulcerative lesions on the tongue. Fabry disease and rheumatoid conditions were ruled out and there were no mutations in SCN9A gene. Treatment with voltage-gated sodium channel blockers (oxcarbacepine-Trileptal®) and anticonvulsants (Perampanel-Fycompa®) did not improve pain symptoms, however, performing moderate physical activity, use of comfortable footwear, and local application of cold resulted in the restoration of patient´s quality of lifeConclusion:To our knowledge, this report described for the first time, the successful treatment of ulcerative lesions of the oral mucosa in Erythromelalgia. We believe that the treatments described here (exercise, comfortable footwear and local application of cold) could improve the quality of life of Erythromelalgia patients.
Keintiman Komunikasi Manusia dan Komputer dalam Film “Her”
Authors: Monggilo Zainuddin Muda Z 
Published: March 2019

The problem of the research was how the communication intimacy showed in the story of “Her” film. The purpose was to describe the tendency of communication intimacy between human and computer in “Her” film. The film was selected because of its unique and interesting concept and story ideas as well as the series of achievements that have achieved in terms of quality and the advantages of worldwide sales. The sample was 28 sequences with a focus on the sequences contained interactions between Theodore and Samantha as the two main characters. Data were collected through observation, documentation, and literature study with quantitative content analysis method. The research was limited to the manifest function of the research object. The results showed that: (i). The most dominant of communication intimacy in the film was the intimacy at the level of stabilization (56%), followed by affective (19.5%), orientation and exploration (9.8%), and depenetration (4.9%), (ii). The most dominant of communication intimacy featured in the film was an intensive communication (22%), and followed by personal topic (stabilization) (17%), confirmation status (15%), and personal topic (exploration) (10%).Keywords: Communication Intimacy, Computer Technology, Quantitative Content Analysis, “Her” Film
Pengaruh Mediasi dari Perceived Responsibilty terhadap Hubungan antara Obedience Pressure dan Budgetary Slack
Authors: Tantri Sakina Nusarifa 
Published: March 2019

This study aims to examine the mediating effect of perceived responsibility on the association between obedience pressure and budgetary slack. The questionnaires were distributed in a survey conducted on 100 participants who are living in Indonesia and involved in the companies budget recommendation. The statistical analysis was performed using SEM. The result of this study showed that obedience pressure has a positive significant effect on budgetary slack and negatively affects perceived responsibility, while perceived responsibility has a negative significant effect on budgetary slack. Further analysis on mediating variable showed that perceived responsibility partially mediated the relationship between obedience pressure and budgetary slack. Keyword: obedience pressure, budgetary slack, perceived responsibility, mediating variable, SEM
El desafío de la relación de trabajo: la tensión de la subordinación y la (des)regulación.
Authors: Arellano Ortiz Pablo 
Published: March 2019

<p>En el presente artículo se reflexiona en torno al derecho del trabajo toando como punto de partida la función protectora de la relación que tiene el mismo en cuanto al trabajo, máxime si se consideran las fuerzas de producción. El análisis revisa la subordinación desde los fenómenos actuales: el mercado laboral como la <em>gigeconomy </em>y los empleos atípicos.<em></em>Asimismo se estudia la tendencia a la desregulación como un factor importante, sosteniendo que los fenómenos que se examinan no degradan el valor de la subordinación como criterio de determinación de la relación de trabajo.</p>
Combate a la corrupción y sociedad
Authors: Ackerman John M. 
Published: March 2019

<p>En 2016, se hizo un intento por reconfigurar el sistema de vigilancia y control del gasto público. Se aprobó una nueva Ley General del Sistema Nacional Anticorrupción (LGSNA), con el objetivo de articular las diferentes partes del enorme rompecabezas que existe en la materia, también se aprobó una nueva Ley General de Responsabilidades Administrativas y una nueva Ley Orgánica del Tribunal Federal de Justicia Administrativa. Adicionalmente, la reforma al artículo 102 constitucional transformó la Procuraduría General de la República en una Fiscalía General de la República con plena autonomía legal del Ejecutivo Federal. El ensayo actual inicia con una reflexión crítica sobre algunas de las reformas recientes y después propone algunas acciones que nos permitirían construir un Sistema Nacional de Transparencia, Fiscalización y Rendición de Cuentas que realmente sirva.</p><div> </div>
Analysis of Financial Inclusion Toward Poverty and Income Inequality
Authors: Zia Ikrima Zaleda , Prasetyo P. Eko 
Published: March 2019

The objective of this study is to analyze the relationship and the influence of financial inclusion toward poverty alleviation and income inequality in Indonesia. The analysis methods in this study were Index Inclusion and regression-correlation of panel data. The variable of financial inclusion was obtained from Index of Financial Inclusion (IFI) value measured by dimensions; banking penetration, banking services availability, and the use of banking services. The data was time series from 2014-2016 and cross section from 33 provinces in Indonesia obtained from Bank Indonesia, Financial Service Authority, and Central Bureau Statistics. The results showed; (1) most provinces in Indonesia had moderate financial inclusion level, (2) financial inclusion had a negative and significant relationship and influence toward poverty. (3) financial inclusion had a positive and not significant relationship with income inequality, but it had a negative and significant influence toward income inequality. It means that financial inclusion can reduce poverty, but it has not been able to reduce the economic gap of society well.
KAJIAN BEBAN PENCEMARAN LIMBAH CAIR DENGAN PARAMETER BOD DAN DO DARI AREA PERMUKIMAN DI SUNGAI CITEPUS
Authors: Pradiko Hary , Yustiani Yonik Meilawati , Santika Santika 
Published: March 2019

Sungai Citepus merupakan sungai yang mengalir melalui daerah Barat kota Bandung dengan berbagai kegiatan masyarakatnya, antara lain permukiman padat/ kegiatan penduduk sehari-hari seperti MCK, home industri atau industri kecil, sehingga sungai Citepus juga merupakan tempat yang potensi untuk pembuangan air limbah dari kegiatan tersebut. Dalam penelitian ini menggunakan metode analisis kualitas air sungai, berdasarkan kualitas indikator pencemaran di Sungai Citepus yang telah dilakukan pada musim hujan. Pengambilan sampel air dilakukan secara sesaat/grab, pengambilan sampel dilakukan di 5 titik pengamatan dimulai di daerah hulu (jl.Dr.Setiabudhi) sampai hilir (Jl.Caringin).Tingkat pencemaran air sungai ditentukan berdasarkan parameter kualitas air BOD dan DO. Persamaan yang digunakan adalah Teori Streeter – Phelps. Dari hasil perhitungan diperoleh bagian hulu sungai kadar BOD-nya antara 6,8 – 7,2 mg/l dan kadar DO 8,4 mg/l. dan dibagian hilir sungai kadar BOD-nya antara 7,0 – 7,5 mg/l dan kadar DO 0,5 – 0,9 mg/l. Berdasarkan hasil diatas maka kondisi sungai dibadian hulu kadar BOD di daerah ini telah melebihi ambang batas (tercemar), tetapi nilai DO sesuai dengan ambang batas, begitu juga dengan bagian hilir sungai nilai BOD telah melewati ambang batas (tercemar) dan kadar DO dibawah ambang batas, menurut SK Gubernur Jawa Barat N0.39 Tahun 2001 yaitu nilai BOD sebesar 6 mg/l dan DO sebesar >3 mg/l.
The Impact of Cognitive and Metacognitive Strategies on Iranian EFL Bilingual versus Monolingual Learners Reading Comprehension ability
Authors: Samadi Fatemeh , Maghsoudi Mojtaba , AzizMohammadi Fatemeh 
Published: March 2019

This study attempts to measure the effect of the implementation of cognitive and metacognitive reading strategies on reading ability of second year high school students who were bilinguals and monolinguals. In order to address these issues, a quantitative study was conducted on 193 EFL bilingual and monolingual students who were randomly selected from some high schools of Markazi province (Arak and Farahan ) . To meet the mentioned aims, subjects were given English proficiency test, reading comprehension test, cognitive and metacognitive strategies questionnaire By utilizing t-test and ANOVA revealed that there would be statistically significant differences between the above-mentioned subjects as follows:
1-There wasn't meaningful difference between female bilingual and female monolingual learners in using cognitive and metacognitive strategies .
2- There was meaningful difference between male bilingual and male monolingual learners in using cognitive and metacognitive strategies .
3- Gender didn't have significant effect on using cognitive and metacognitive strategies in EFL learners reading comprehension ability.
The study of pro as an empty category in Azeri Turkish language
Authors: Nezhad Mohammad Reza Pahlavan , Habibi Mozhghan 
Published: March 2019

This paper examines the pro-drop parameter in Azeri Turkish. First, some basic concepts and theories in terms of Chomsky's generative grammar school and principles and parameters theory are introduced. Then some theoretical background on the subject of Persian and Turkish languages are briefly presented. Next part is about explanation and description of pro features and some evidence and samples of Italian and Persian and Azeri Turkish languages and the last section deals with the results of this study. After giving and comparing evidence of these three languages we conclude that is that Azeri Turkish is a pro-drop language which allows subject to drop and establishes pro as a null subject (an empty category) in the position of subject and object can also be removed in some instances and proarb is established in the position of object.
STUDY OF PERCEPTIONS AND THE ROLE OF ESP TEACHERS ABOUT EFFECTIVENESS OF ESP COURSES IN LANGUAGE TEACHER EDUCATION DURING PRE-AND IN-SERVICE TEACHING PRACTICE
Authors: Artishedar Nesa , Najafi Fatemeh , Najafi Fatemeh , Najafi Fatemeh , Bijani Houman , Bijani Houman , Bijani Houman 
Published: March 2019

It is believed that the time that the undergraduate students register in Teacher Education Program they have an extensive amount of experience, but English for specific purpose (ESP) teachersor pre-service ESP teachers are regarded as valuable resources for recognizing attitudes or perceptions of effectiveness of ESP teachers whose classless are taught by them. Pre-service teachers surely have several specific perceptions about their future career and the effectiveness of ESP teachers whose classes are being taught by them during practice teaching. If ESP teachers are asked the question why do you want to be anESP teacher? They may have different responses such as: I want to be an ESP teacher because I have a very good image of my teachers during my school period or I want to be a ESP teacher because I would like to follow the methods and procedures of effective teaching that my university teachers did during teaching specific courses. However, some might have an opposite perception. Anyway, this study tries to compare the perceptions of ESP teachers before (pre-service) and after (in-service) teaching period.
Reading in Arabic Orthography: The influence of Short Vowels on Reading Accuracy and Comprehension of Poor and Normal Arabic Readers
Authors: Rabia Salim Abu , Salfeety Abedalhakeem 
Published: March 2019

Research conducted on strategies aimed at improving reading skills and comprehension among Arabic readers (Abu Rabia, 1997, 1998) reported on the contribution, of the addition of short vowels to Arabic texts, to both the acquisition of proper reading skills during early childhood, and to better reading comprehension among all ages. The findings were considered controversial. Such a determination can have important implications for both local and national educational policies seeking the improvement of reading skills and comprehension among Arabic readers of all ages. In this study, 60 native Arabic speakers, 12 years old were sampled from school in northern Israel. They were divided into two equal groups of 30 normal and 30 poor readers, based on their average grade point average in the Arabic Language subject. The results indicated that the vocalization of Arabic texts significantly improved both reading accuracy and comprehension among all participants, whether normal or weaker readers. Further, despite the very noticeable difference between reading abilities among the two groups (regular and weak readers) at the outset, on the average we found that the addition of short vowels helped both groups acquire basic reading skills. The findings indicated that the use of vocalized texts helps readers achieve higher reading comprehension levels among all types of readers.
The Professional Competence Formation of High School Students based on the System Approach.
Authors: Yessekeshova Maral , Gulnur Isakova , Gulzhakhar Seilkhan , Gulnar Kaltayeva , Botagoz Bermukhambetova 
Published: March 2019

This study addresses the issue of implementing a system approach during the higher school specialists preparation, which effectively leads to their professional competence formation. The study results of higher education teachers professional difficulties in the interaction with the educational process participants are presented. The training technology on the system approach basis creates conditions for the learning process participants’ activities systemic organization, as well as for the system thinking skills and the system approach developing in cognitive, practical and other ongoing and forthcoming activities. An important factor in the future specialists’ professional competence formation is an indicative basis formation for their future professional activity. The professional competence structure and components characteristic are given. Examples are also presented, that demonstrate the professional competence formation implementation with a focus on current society needs. There is a description of the students’ considerable professional competence increase after its formation methods correction.
Moderation and Modernism in India’s Nuclear Policy: Post 1974 Era
Authors: Singh Dr. Rajkumar , Kumari Hemlata 
Published: March 2019

India, after its first nuclear explosion in 1974 moved to modernize and moderate nuclear policy as security environment in the region deteriorated further due to China, pursuing a strategy of containing India by using Pakistan as a surrogate, had supplied technology nuclear materials andwarhead designs for the Pakistani bomb. Clearly with Chinese help Pakistani detonated six nuclear devices as follow up of India’s repeat detonation in the second week of May 1998. This development changed the security environment in South Asia forever and this time India convinced the international community that it would not become a destabilising nuclear force in the international system. Thus, in the post-1998 era India adopted two concepts, (i) No first use for attack or war and (ii) Credible minimum deterrence. As a step further in the direction India also signed with the US a nuclear deal under which it agreed to separate its civil and military nuclear facilities under international safeguard and supervision. The paper analyses the evolution of India’s nuclear capability in regional and global contexts.
Epidemiology of coronary abnormalities of discharge and branching and their clinical significance
Authors: Abbasov E. F. , Manafov S. S. , Abdullayev F. Z. , Abbasov F. E. , Akhundova A. G. 
Published: March 2019

Purpose.Until the mid-20th century they could be discovered only during autopsy, it means after death. With the introduction of coronary angiography it become possible to find them in a living person. Later on, new modalities such as computed tomography (CT) and magnetic resonance imaging (MRI) enhanced futher our abilities. It is very important to discover coronary anomalies in a living person, because some of them could lead to sudden cardiac death (SCD). In fact, coronary artery anomalies are the second main cause of the SCD in young athletes. Another importance is driven by the fact, that some of them could lead to lifethreatening complications during cardiac surgery when unknown before the operation.Methods.We prospectively reviewed all coronary angiography films from 2011 to 2016 in our center. Coronary anomalies were reviewed and classified by two independent experienced operators. Patients with congenital heart disease and coronary fistulas were excluded.Results.Out of 5055 patients 148 (2.9%) had coronary artery anomalies of origin and distribution. Those were 120 men (81.1%) and 28 women (18.9%) with an age range between 29 to 88 years. The three most common anomalies were myocardial bridge (48.7%), separate origin of the conus branch (13.5%) and separate origin of the LAD and LCX (8.1%).Conclusion.In our study we found more or less the same types and incidence rates of coronary artery anomalies as in the world literature. We had apparently higher rates of myocardial bridges, compared to average number on angiography studies, but very close to authopsy study rates.
Urgent surgery – the role of computed tomography
Authors: Arablinskiy A. V. , Rumer V. B. 
Published: March 2019

Introduction.Acute abdomen is a complex condition that demands urgent diagnostics and treatment.The proposeof the study based on data we got in the Radiology Department of S.P. Botkin Municipal Clinical Hospital is to evaluate the role of computed tomography in acute abdomen diagnostics.Materials and methods. 637 acute abdomen patient`s data were retrospectively analyzed, provided in the term from January 2017 to January 2018. The average age was 53 years old, from 18 to 98 y.o. Male to female ratio was 1:1,51, male – 383, female – 254. Inclusion criteria was acute abdomen clinical presentation.Results.The most frequently seen conditions were ileus – 226 cases (35.5%), acute pancreatitis/pancreonecrosis – 185 cases (29%), ureteral occlusion with stones – 83 cases (13%), blunt abdominal trauma – 57 cases (9%), renal abscesses and inflammation diseases – 56 cases (9%). Liver abscesses – 13 cases (2%), mesenteric ischemia – 10 cases (1.5%), acute appendicitis – 4 (0,5%), aortic dissection – 2 cases (0,3%), hollow viscus perforation – 1 case (0.2%).Conclusion.CT with high accuracy and in a short time identify the reason of acute abdomen in all shown cases that highly improve the quality of medical management.
METACOGNITIVE SKILLS IN MATHEMATICS PROBLEM SOLVING
Authors: Lestari Wahyu , Pratama Loviga Deni , Jailani Jailani 
Published: March 2019

This study is a descriptive qualitative approach. The purpose of this study was to describe level metacognitive skills of students in solving the problem solving test item based on indicators that had been compiled. Metacognitive skills in this study form planning, monitoring, reflection aspect. Data analysis aimed to describe the students’ metacognitive skills. Then, the researcher categorized the students’ metacognitive skills into reflective use, strategic use, aware use, and tacit use. The data collection methods in this study were documentation, test, and interview. From 40 student spread across many Junior High Schools in Jember district, 8 students are found to be able reading and writing of what was known (P-1), determining solving strategies (P-2), Using rules (M-1), and monitoring carefully (M-2), thus classified as having metacognitive skills into aware use. Furthermore, 20 students are able to perform (P-1), (P-2), planning intermediate results (P-3), (M-1), (M-2), able to correct mistake (M-3), and Reflecting achievement of the objectives (R-1), thus classified as having metacognitive skills into strategic use. Furthermore, 12 students are able to perform (P-1), (P-2), (P-3), (M-1), (M-2), (M-3), (R-1), do wareness on the application/use of strategies (R-2), analyze the text/formula (R-3), choosing intentionally the representation (R-4), thus classified as having metacognitive skills into reflective use