bluuebunny/crossref_metadata_2025_split huggingface dataset:
Neurofilament light chain plasma levels in major depressive disorder: a brief research report
Authors: Fernández-Pereira Carlos , Fernández-Ceballos María de los Ángeles , Olivares José Manuel , Prieto-González José M. , Agís-Balboa Roberto Carlos 
Published: November 2024

IntroductionPeripheral neurofilament light chain (NfL) reflect neuronal and axonal damage. Most studies have been focused on NfL cerebrospinal fluid measures since peripheral levels were difficult to detect. However, with recent advent of single molecule array (SIMOA) technology, NfL is now detectable peripherally at small concentrations (pg/ml). In neurodegenerative disorders, NfL peripheral levels have been found significantly elevated compared against psychiatric disorders. However, there is still controversy of whether NfL peripheral levels might be altered in psychiatric disorders like major depressive disorder (MDD) when compared against a normal population.MethodsWe have measured NfL plasma levels by using single molecule array (SIMOA) technology in a Spanish small cohort of MDD patients (n = 15) and a HC group (n = 15). We have used subjective scales to estimate depression severity (HDRS), anhedonia (SAAS), the general cognitive state (MMSE) and episodic memory (FCSRT) in MDD patients.ResultsWe have not detected a significant alteration in NfL plasma levels in MDD patients when compared against the HC subjects (U = 97, p-value = 0.532). Moreover, we have not detected any significant correlation between NfL plasma levels with any subjective scales. The only parameter that significantly and positively correlated with NfL plasma levels was age in both MDD and HC.DiscussionSignificant alteration in NfL plasma levels in MDD patients might reflect neurobiological changes behind the predisposition to develop future neurodegenerative disorders such as Alzheimer’s or Parkinson’s diseases for which depression represents a risk factor. However, whether there is an increase in NfL due to MDD regardless of the ageing process is still a matter of debate.
Unraveling the relationships among pandemic fear, cyberchondria, and alexithymia after China’s exit from the zero-COVID policy: insights from a multi-center network analysis
Authors: Li Yuan , Li Jie , Zhou Chunfen , Huang Chuanya , Luo Biru , Hu Yanling , Huang Xi , Fang Jinbo 
Published: November 2024

ObjectiveChina’s abrupt exit from the zero-COVID policy in late 2022 led to a rapid surge in infections, overwhelming healthcare systems and exposing healthcare providers to intensified psychological pressures. This sudden shift exacerbated pandemic-related psychological issues, including fear, health anxiety, and emotional processing difficulties. This study aimed to unravel the relationships among pandemic fear, cyberchondria, and alexithymia following China’s exit from the zero-COVID policy.MethodsA multi-center cross-sectional survey was conducted among 4088 nurses from 43 public hospitals in China. The web-based survey comprised the Fear of COVID-19 Scale, Cyberchondria Severity Scale, and Toronto Alexithymia Scale. Network analysis was employed to explore the interconnections and identify central components within these psychological and behavioral constructs.ResultsThe analysis revealed a dense network with predominantly positive connections. Specific aspects of cyberchondria and pandemic fear exhibited the highest strength centrality, indicating their critical influence. The externally oriented thinking dimension of alexithymia emerged as a crucial bridge node, linking pandemic fear and cyberchondria. The network structure demonstrated consistency across diverse educational backgrounds and career stages.ConclusionThese findings highlight the need for targeted interventions focusing on key network components, particularly externally oriented thinking, to disrupt the detrimental cycle of pandemic fear and cyberchondria. Healthcare organizations should promote balanced objective fact-focused and problem-solving approaches while also fostering skills in emotional awareness and expression, thereby mitigating the risk of maladaptive pandemic fear responses and dysfunctional online health information-seeking behaviors.
Elevated remnant cholesterol and the risk of prevalent major depressive disorder: a nationwide population-based study
Authors: Tao Shiyi , Yu Lintong , Li Jun , Wu Ji , Yang Deshuang , Huang Xuanchun , Xue Tiantian 
Published: November 2024

BackgroundRemnant cholesterol (RC) has received increasing attention due to its association with a variety of diseases. However, comprehensive population-based studies elucidating the relationship between RC and major depressive disorder (MDD) are limited. The current study aimed to determine the association between RC and MDD in US adults.MethodsCross-sectional data of US adults with complete RC and depression information were obtained from the National Health and Nutrition Examination Survey (NHANES) 2005-2018. MDD was evaluated using the Patient Health Questionnaire (PHQ-9). Multivariate logistic regression, sensitivity analysis, and spline smoothing plot method were conducted to explore the relationship between RC and depression. The cut-off point was calculated using recursive partitioning analysis when segmenting effects emerged. The area under the receiver operating characteristic (ROC) curve (AUC), calibration curve, Hosmer-Lemeshow test, the decision curve analysis (DCA), and clinical impact curve (CIC) were employed to evaluate the performance of RC in identifying MDD. Subgroup analyses and interaction tests were performed to explore whether the association was stable in different populations.ResultsA total of 9,173 participants were enrolled and participants in the higher RC quartile tended to have a higher PHQ-9 score and prevalence of MDD. In the fully adjusted model, a positive association between RC and PHQ-9 score and MDD was both observed (β=0.54, 95% CI 0.26~0.82; OR=1.43, 95% CI 1.15~1.78). Participants in the highest RC quartile had a 0.42-unit higher PHQ-9 score (β=0.42, 95% CI 0.15~0.69) and a significantly 32% higher risk of MDD than those in the lowest RC quartile (OR=1.32, 95% CI 1.05~1.66). Spline smoothing plot analysis further confirmed the positive and non-linear association between RC and PHQ-9 and MDD. ROC analysis (AUC=0.762), the Hosmer-Lemeshow test (χ2 = 6.258, P=0.618), and calibration curve all indicated a high performance and goodness-of-fit of the multivariate model. DCA and CIC analysis similarly demonstrated a positive overall net benefit and clinical impact for the model. Subgroup analyses and interaction tests suggested that the relationship between RC and depression remained stable across subgroups and was unaffected by other factors other than diabetes, hypertension, or hyperlipidemia.ConclusionAn elevated RC is associated with a higher risk of prevalent MDD among US adults, especially in those with diabetes, hypertension, or hyperlipidemia. The present results suggested that the management of RC levels and comorbidities may contribute to alleviating the occurrence of MDD.
Cardiovascular, perceptual, and performance responses to single- vs. multi-chambered blood flow restriction cuffs
Authors: Rolnick Nicholas , de Queiros Victor S. , Moghaddam Masoud , Peikon Evan , Taylor Susannah , Watson Samantha , Ruffhead Campbell , Zupnik Sean , Werner Tim 
Published: November 2024

IntroductionThis study aimed to investigate the impact of the blood flow restriction bladder type (single- [SC-BFR] vs. multi-chambered [MC-BFR]) on exercise performance, cardiovascular responses, and perceptual experiences with exercise sessions incorporating multiple sets to volitional failure in a randomized, crossover experimental design.MethodsTwenty-seven healthy, physically active participants (age: 22.6 ± 5.7; weight: 74.3 ± 15.8 kg; height: 171.7 ± 7.7 cm; BMI: 25.0 ± 4.1 kg/m2; ∼93% reported regular resistance training within 6 months; 11 females) randomly performed exercise to failure (4× sets to failure, 20% 1RM, 1 min rest between sets) in each of three conditions: SC-BFR (using the Delfi Personalized Tourniquet Device inflated to 60% limb occlusion pressure), MC-BFR (using the B Strong Cuffs inflated to 300 mmHg according to manufacturer recommendations), and N-BFR (no BFR control).ResultsSC-BFR blunted post-exercise increases in carotid-femoral pulse wave velocity (p = 0.328) (+3.3%) whereas the other conditions showed elevations (MC-BFR +11.8% [p = 0.041], N-BFR +9.3% [p = 0.012]). Discomfort was lower in N-BFR compared to SC-BFR (p &lt; 0.001) and MC-BFR (p = 0.035) but all displayed similar exertion (p = 0.176). Median total repetitions achieved were significantly less in SC-BFR (57 [25–75th percentile: 47–65) than MC-BFR (76 [63–91] (p = 0.043) and N-BFR [106 (97–148)] p = 0.005). Per set repetition volumes were similar on set 1 between SC-BFR (p &lt; 0.001) and MC-BFR (p = 0.001) and were lower than N-BFR (p ≤ 0.001) whereas in sets 2–4, MC-BFR performed similar number of repetitions as N-BFR (p = 0.984–1.000).ConclusionBladder design of a BFR cuff has an impact on the acute responses to exercise if applied according to recommended application guidelines, as SC-BFR impacts performance to a greater degree and mitigates post-exercise arterial stiffness responses compared to MC-BFR and N-BFR while both BFR conditions display greater levels of discomfort compared to N-BFR.
Clinical Trial RegistrationNCT06276673.
Development of a multiplex real-time PCR for the simultaneous detection of monkeypox virus clades I, II, and goatpox virus
Authors: Lin Yongqiang , Guo Zijing , Chen Jinsong , Zhang Xianwen , Zhou Long , Li Yanmin , Zhang Zhidong 
Published: November 2024

IntroductionMonkeypox virus (MPXV) hosts are of multiple species, with a risk of cross-species transmission. This phenomenon poses a threat to unreported affected domestic animals and increases the risk to human public health. Clinical diagnostics continue to face challenges regarding specificity among poxviruses. The need for a rapid and precise assay to differentiate between MPXV clades I and II, as well as goatpox virus (GTPV) is essential for enhancing our capacity for disease prevention, control, and epidemiological investigation.MethodsTo address this need, we have successfully developed a multiplex real-time PCR assay targeting MPXV D14L gene for clade I, MPXV D18L gene for clade II, and GTPV RPO30 gene, which can simultaneously detect MPXV clades I and II as well as GTPV.ResultsThe developed assay demonstrated high sensitivity, with limits of detection at 207.83 copies/reaction for MPXV clade I, 252.07 copies/reaction for MPXV clade II, and 208.72 copies/reaction for GTPV. Importantly, there was no cross-reactivity with other non-pox viruses which infect goats. The assay exhibited excellent repeatability, with coefficients of variation (CV%) for intra-assay and inter-assay ranging from 0.17% to 0.89% and 0.58% to 1.09%, respectively.DiscussionThis assay can serve as a vital resource to safeguard against the MPXV epidemic posing a threat to the life safety of goats, to mitigate potential risks to the sheep farming industry, and to prevent the transmission of MPXV to humans through sheep, which could act as a potential transmission vector for infection.
ULTRASOUND GUIDED MAXIMAL SAFE RESECTION OF MALIGNANT BRAIN TUMORS
Authors: Petrescu George E.D. , Sirbu Octavian , Gorgan Radu M. 
Published: November 2024

Introduction
Intraoperative ultrasound (IOUS) is a non-invasive technique that is increasingly used in neurosurgery, especially in oncological pathology. The main advantage consists of offering a real time image and can help localize the lesion and guide the extent of resection.

Material and Methods
We describe our experience at Bagdasar-Arseni Clinical Emergency Hospital from a prospectively maintained database of malignant CNS tumors where IOUS was used over the past three years.

Results
Intraoperative ultrasound (IOUS) was routinely employed in the resection of brain tumors, proving helpful not only in localizing the lesion but also in determining the extent of resection. This was particularly useful for diffuse infiltrative lesions such as gliomas. Moreover, in patients with multiple metastases, where the neuronavigation system was limited due to brain shift following the resection of one lesion, IOUS was very efficient in determining the location.

Conclusion
Intraoperative ultrasound is a widely adopted technique in neurosurgery, aiding neurosurgeons achieve maximal safe resection of brain and spinal tumors. Its main advantages include quick, real-time image acquisition, compensation for brain shift, and integration with neuronavigation systems. The most significant limitation, however, is the relatively long learning curve associated with mastering the technique.
Abnormal Stock Market Returns to Business Model Extension Announcements: Value Drivers & Moderators
Authors: Werner Thiemo , Hoffmann Werner 
Published: November 2024

The value-creation potential of business model extensions (BME) in incumbent companies remains a subject of ongoing debate and is currently not substantiated by market-value focused empirical research. Especially the moderating role of economic uncertainty and the interplay with traditional product-industry diversification have not been empirically examined. This study aims to close that gap. We utilize an event study setup to measure the value-creating effect of BME and its moderators. Using a unique dataset of joint ventures in the high-tech industry industry, we measure the effects of BME and its moderators on abnormal stock market returns. Our findings indicate that BME leads to higher abnormal stock market returns. This effect is further amplified under company-level, industry-level, and macroeconomic uncertainty. Additionally, we discover that, under these uncertainties, combinations of BME and product-industry diversification are value-creating, whereas product-industry diversification alone tends to be value-destroying.
Entrepreneurial Leadership Development in the Digital Age
Authors: Joaquim Anafilipa , Figueiredo Paula 
Published: November 2024

During the second half of the 21st century, academia has presented different studies to conceptualize entrepreneurial leadership without academic consensus.Although leadership and entrepreneurship are distinct, the literature has come to understand their similarities (Harrison et al., 2020). Despite the large number of publications, the characteristics of a leader should be based on an entrepreneurial profile, mainly to gain competitive differentiation for companies through the productivity of their human capital (Addy et al., 2024). Over the last century, the business world has undergone several transformations intrinsically linked to innovations and developments in Information and Communication Technologies. Over the last few decades, the installed business park has changed in computerization and automation, making it necessary to equip human resources with ICT-related tools and knowledge. This and several generations cooperating in companies have brought new challenges to leadership (Figueiredo and Joaquim, 2023). However, in contemporary times, the business sector has to acknowledge the challenges inherent in meeting ESG indicators to respond to the SDGs, forcing leaders to equip themselves with entrepreneurial skills to involve, motivate, and create strategies for promoting innovation and retaining talent (Addy et al., 2024). According to Omeihe et al. (2023), “the role of entrepreneurial leadership in enhancing positive business outcomes” (2023, p. 1), but the authors also acknowledge that leaders should embrace several attributes and skills to implement this new leadership perspective. The entrepreneur concept has gained new topics to discuss and internalize, including ICT and the sustainable domains paradigms regarding the ESG indicators and the SDG goals. This article aims to understand the challenges and competencies needed to conceptualize entrepreneurial leadership by critically reviewing the existing literature and linking it to the inherent needs of ESG and SDG goals; it seems to be the only way to understand and internalize the processes and procedures involved in entrepreneurial leadership in the digital age.
Mapping the Landscape of Team Roles: A Cluster Analysis of Key Authors
Authors: Dočekal Vít 
Published: November 2024

This paper is a continuation of the presentation of results from a systematic literature review aimed at identifying key authors in the field of team roles and grouping them into clusters of interconnected authors. It aims to define clusters of authors focusing on team roles. The results of this work can serve to facilitate future researchers' orientation to the different typologies of team roles. The defined clusters can also be used by practitioners in the field due to the clarity of studies describing team roles. The methodology utilized in this study involved a systematic literature review followed by an analysis of author relationships through systematic literature mapping. As described by Soaita et al (2020), systematic literature mapping is considered a valuable tool for comprehensively understanding the structure of a specific topic. Following the guidelines proposed by Kuckartz and Rädiker (2019) for conducting a literature review based on literature search, we proceeded through the described phases. The obtained results have brought about surprising insights, particularly the strongly developed cluster around J. E. Mathieu. The cluster centred around S. K. Parker is also interesting in terms of its gradual linking pattern, where authors build upon each other's work gradually. The presented results serve as an initial exploratory input for further research on theories, concepts and models of typologies and taxonomies. The groups of approaches to team roles depicted in this study clarify the
The Role of Awareness and Level of Digital Literacy in Creating Entrepreneurial Intentions of Generation Z Women
Authors: Lemańska-Majdzik Anna , Okręglicka Małgorzata 
Published: November 2024

Currently, modern market conditions for the development of entrepreneurship are extremely uncertain and highly turbulent. The speed and intensity of changes in the business environment make starting your own business a high risk. Entrepreneurial intentions play a particularly interesting role in the decision-making process to start your own business. The literature review indicates that the factors influencing intentions include the abilities and skills of future entrepreneurs, including their level of digital skills and competence. Knowledge of digital technologies enables future entrepreneurs to access reliable and up-to-date information and increases the opportunities for continuous learning. Digital literacy facilitates effective communication and collaboration between businesses. These competencies help to understand the implications of using digital technologies and support the use of digital tools in company management. The aim of the paper is to identify the awareness and digital literacy that influence the entrepreneurial intentions of Generation Z women. The study conducted in 2024 is based on the results of research on a group of 193 Polish women, representatives of Generation Z. An original survey questionnaire was used to collect the data. An original survey questionnaire was used to collect the data. The analysis based on the data showed the level of digital literacy of Polish Generation Z women and which of them influence the level of entrepreneurial intentions. The novelty of the paper is the indication of areas of knowledge regarding digital skills that determine the entrepreneurial intentions of Polish Generation Z women.
What is the Role of Social Capital in the Innovation Creation Process? Evidence from the European Union
Authors: Akça Emrah Eray , Bayraktar Murat 
Published: November 2024

This study empirically analyzes whether social capital has any role in shaping the innovation creation process in 25 members of the European Union over the period 2013-2021. In this context, the innovation model is constructed utilizing balanced panel data and hierarchically estimated with the Poisson Pseudo Maximum Likelihood (PPML) method which is the most appropriate method since the model includes some negative values and count data. The finding strongly supports the encouraging effect of social capital on innovation since it is statistically significant and positive in all model specifications. Besides, the innovation creation process is positively associated with human development, research and development expenditure, population, government effectiveness, and income per capita. When comparatively evaluated estimation results, human development, and social capital lead to forth in terms of contributing more innovation creation process. As a core result of the study, social capital may be considered the workhorse for the innovation creation process since it promotes better coordination of activities through improved interpersonal interactions, increased community trust, and vision-sharing, leading to increased market efficiency and decreased costs. Therefore, it is recommended that these countries develop strategies to enhance their social capital and implement policies to increase especially in bridging and linking social capital, which generates a competitive advantage over their rivals.
Analisis Perlakuan Akuntansi Musyarakah Berdasarkan PSAK Syariah 106 di BMT UGT Nusantara Wongsorejo Kabupaten Banyuwangi
Authors: Lestari Fira Maidina , Zakiyah Makhshushi 
Published: November 2024

BMT UGT Nusantara Wongsorejo Kabupaten Banyuwangi dengan beberapa produk yang sudah ada memerlukan standar akuntansi yang berdasarkan prinisip syariah untuk menjalankan sistem dalam melayani masyarakat dan meningkatkan kepercayaan Masyarakat. Penelitian ini bertujuan untuk mendeskripsikan perlakuan akuntansi musyarakah berdasarkan PSAK106 di BMT UGT Nusantara Wongsorejo, Penelitian ini dikategorikan sebagai penelitian lapangan dengan pendekatan kualitatif. Berdasarkan hasil penelitian, bahwa perlakuan musyarakah di BMT UGT Nusantara yang berisi tentang: pertama, Pengakuan akuntansi terhadap pembiayaan musyarakah masih belum sepenuhnya sesuai dengan PSAK 106. Kedua, Pengukuran akuntansi pembiayaan musyarakah telah sesuai dengan PSAK 106. Ketiga, Penyajian akuntansi musyarakah tidak sesuai dengan PSAK 106 karena kas yang diberikan kepada nasabah disajikan sebagai pembiayaan musyarakah. Keempat, Pengungkapan akuntansi terhadap pembiayaan musyarakah tidak dapat dianalisis karena pihak BMT tidak membuat catatan atas laporan