bluuebunny/crossref_metadata_2025_split huggingface dataset:
Intranasal Nanovaccine Confers Homo‐ and Hetero‐Subtypic Influenza Protection
Authors: Qi Mi , Zhang Xian‐En , Sun Xianxun , Zhang Xiaowei , Yao Yanfeng , Liu Siling , Chen Ze , Li Wei , Zhang Zhiping , Chen Jianjun , Cui Zongqiang 
Published: February 2018

AbstractCross‐protective and non‐invasively administered vaccines are attractive and highly desired for the control of influenza. Self‐assembling nanotechnology provides an opportunity for the development of vaccines with superior performance. In this study, an intranasal nanovaccine is developed targeting the conserved ectodomain of influenza matrix protein 2(M2e). 3‐sequential repeats of M2e (3M2e) is presented on the self‐assembling recombinant human heavy chain ferritin (rHF) cage to form the 3M2e‐rHF nanoparticle. Intranasal vaccination with 3M2e‐rHF nanoparticles in the absence of an adjuvant induces robust immune responses, including high titers of sera M2e‐specific IgG antibodies, T‐cell immune responses, and mucosal secretory‐IgA antibodies in mice. The 3M2e‐rHF nanoparticles also confer complete protection against a lethal infection of homo‐subtypic H1N1 and hetero‐subtypic H9N2 virus. An analysis of the mechanism of protection underlying the intranasal immunization with the 3M2e‐rHF nanoparticle indicates that M2e‐specific mucosal secretory‐IgA and T‐cell immune responses may play critical roles in the prevention of infection. The results suggest that the 3M2e‐rHF nanoparticle is a promising, needle‐free, intranasally administered, cross‐protective influenza vaccine. The use of self‐assembling nanovaccines could be an ideal strategy for developing vaccines with characteristics such as high immunogenicity, cross‐protection, and convenient administration, as well as being economical and suitable for large‐scale production.
Long‐Term Survival and Prognostic Factors of Pulmonary Metastasectomy in Liver Cancer: A Systematic Review and Meta‐Analysis
Authors: Wang Chong , Yang Lei , Liang Zikun , Liu Yaodong , Liu Shuku 
Published: February 2018

AbstractBackgroundLung is the most common extrahepatic metastatic organ of liver cancer. Surgical resection is a common local treatment for pulmonary metastasis. But the long‐term prognosis of pulmonary metastasectomy varies greatly due to the small sample size and different results of previous studies. Therefore, we conducted this meta‐analysis to evaluate the combined 5‐year overall survival (OS) rate and prognostic factors after pulmonary metastasectomy in liver cancer.MethodsKey words such as liver cancer pulmonary metastasis and metastasectomy were retrieved firstly in PubMed, Cochrane Library, Embase and Chinese Wanfang databases. Eligible studies were identified by manual searches. Each included study should report 5‐year OS rate and/or prognostic factors of pulmonary metastasectomy. Newcastle–Ottawa Scale was used for quality assessment, and heterogeneity was estimated by I2. We calculated the combined 5‐year survival rates and determined the prognostic factors for OS by the hazard ratios (HR) and number of events.ResultsSeventeen cohort studies with a total of 513 patients were included in this meta‐analysis. The combined 5‐year survival rates after pulmonary metastasectomy were 33% [95% confidence interval (95% CI) 29–37%]. The poor prognostic factors were disease‐free interval (DFI) < 12 months (HR = 2.421 95% CI 1.384 4.236) and existence of cirrhosis (HR = 1.936 95% CI 1.031 3.636).ConclusionThe 5‐year OS rate of patients with pulmonary metastasectomy after resection of primary liver cancer is 33%. DFI < 12 months and existence of cirrhosis are probably poor prognostic factors.
Fast and accurate quantitative organic acid analysis with LC‐QTOF/MS facilitates screening of patients for inborn errors of metabolism
Authors: Körver‐Keularts Irene M. L. W. , Wang Ping , Waterval Huub W. A. H. , Kluijtmans Leo A. J. , Wevers Ron A. , Langhans Claus‐Dieter , Scott Camilla , Habets Daphna D. J. , Bierau Jörgen 
Published: February 2018

AbstractSince organic acid analysis in urine with gaschromatography‐mass spectrometry (GC‐MS) is a time‐consuming technique, we developed a new liquid chromatography‐quadrupole time‐of‐flight mass spectrometry (LC‐QTOF/MS) method to replace the classical analysis for diagnosis of inborn errors of metabolism (IEM). Sample preparation is simple and experimental time short. Targeted mass extraction and automatic calculation of z‐scores generated profiles characteristic for the IEMs in our panel consisting of 71 biomarkers for defects in amino acids, neurotransmitters, fatty acids, purine, and pyrimidine metabolism as well as other disorders. In addition, four medication‐related metabolites were included in the panel. The method was validated to meet Dutch NEN‐EN‐ISO 15189 standards. Cross validation of 24 organic acids from 28 urine samples of the ERNDIM scheme showed superiority of the UPLC‐QTOF/MS method over the GC‐MS method. We applied our method to 99 patient urine samples with 32 different IEMs, and 88 control samples. All IEMs were unambiguously established/diagnosed using this new QTOF method by evaluation of the panel of 71 biomarkers. In conclusion, we present a LC‐QTOF/MS method for fast and accurate quantitative organic acid analysis which facilitates screening of patients for IEMs. Extension of the panel of metabolites is easy which makes this application a promising technique in metabolic diagnostics/laboratories.
The effect of parental style on bullying and cyber bullying behaviors and the mediating role of peer attachment relationships: A longitudinal study
Authors: Charalampous Kyriakos , Demetriou Constantina , Tricha Loukia , Ioannou Myria , Georgiou Stelios , Nikiforou Militsa , Stavrinides Panayiotis 
Published: February 2018

ABSTRACTThe purpose of the present study was the examination of the longitudinal effect of parental style on short‐term changes in conventional and cyber forms of bullying/victimization, and the investigation of the mediating role of peer attachment relationships on this effect. The participants were 861 children and adolescents (52% girls, Mage = 11.72 years) attending Cyprus public institutions. Students provided information during three measurement points. There was a six and a 12 week interval among the three measurement points, respectively. The findings of the study indicated that parenting seems to be a significant predictor of all forms of bullying/victimization, conventional and cyber, in early adolescents, even when accounting for bullying/victimization levels eighteen weeks back. More importantly, results showed that the effect of parental style on bullying forms was mediated by peer attachment relationships. Results are discussed in the light of theoretical and practical implications.
Periodontal prosthesis in contemporary dentistry
Authors: Liu Chiun‐Lin Steven 
Published: February 2018

AbstractIn the last 5 decades, the developments of osseointegrated titanium implants (since 1965) have led to the success of contemporary dentistry. Endosseous implant‐supported restorations delivered in accordance with the traditional Branemark protocol have proven to be highly predictable. Today, implants are becoming increasingly common in dental care and provide more therapeutic options, but treatment planning and the sequencing of therapy are critical in implant‐assisted and implant‐supported cases. Implant prostheses give patients and dentists more options in treatment planning, but also present challenging decisions regarding implant surgery. In essence, the emerging thought is that teeth are expendable, as we now have implants to solve these problems. The fact that peri‐implantitis is no simple problem to treat does not seem to affect many who hold that thought. In this article, the authors explain how to properly apply the periodontal prosthesis philosophy, concepts, principles, and techniques in contemporary dentistry. (This article is an update from the article was published in 2005) [1].
Migração do fio de Kirschner após o tratamento da luxação acromioclavicular para o ombro contralateral – relato de caso
Authors: Palauro Fabiano , Stirma Guilherme , Secundino Armando , Riffel Gabriel , Baracho Filipe , Dau Leonardo 
Published: February 2018

ResumoO uso dos fios metálicos, denominados fios de Kirschner, é um método de fixação simples e eficaz para a correção de fraturas e luxações do ombro na cirurgia ortopédica. Uma das possíveis complicações é a migração do fio durante o acompanhamento pós-operatório. Os autores apresentam um caso de um paciente masculino de 48 anos, administrador, que sofreu uma queda de mesmo nível com trauma em ombro direito durante uma partida de futebol. Atendido em um hospital de referência de ortopedia e traumatologia, foi diagnosticada luxação acromioclavicular grau V. Quatro dias após o trauma, fez-se o tratamento cirúrgico da luxação acromioclavicular com amarrilhos com fios de âncora, transferência do ligamento coracoacromial e fixação com fio de Kirchner do acrômio à clavícula. No retorno, 12 dias após o procedimento cirúrgico, identificou-se a migração do fio de Kirschner do bordo do acrômio. Apesar de orientado a se submeter a cirurgia para remoção do fio, o paciente se recusou. Nove meses após o tratamento cirúrgico, o paciente apresentou dores no ombro esquerdo (lado contralateral), dificuldade para mobilizar o ombro, equimose e saliência. Foram feitas radiografias bilaterais e foi constatado que o fio de Kirschner, originalmente no ombro direito, estava no ombro contralateral. Fez-se então cirurgia para remoção do implante, com sucesso.
Tratamento de fraturas patológicas tumorais diafisárias do úmero com haste intramedular rígida bloqueada estática – Experiência de 22 anos
Authors: Moura Diogo Lino , Alves Filipe , Fonseca Rúben , Freitas João , Casanova José 
Published: February 2018

Resumo
Objetivo Estudo retrospectivo observacional em pacientes submetidos à fixação com haste intramedular de fratura patológica tumoral consumada ou iminente da diáfise do úmero em contexto de doença tumoral disseminada ao longo de 22 anos na mesma instituição.
Métodos Amostra com 82 pacientes e 86 fixações do úmero com haste intramedular rígida bloqueada estática não fresada anterógrada ou retrógrada.
Resultados Os tumores primários mais prevalentes foram carcinoma da mama (30,49%), mieloma múltiplo (24,39%), adenocarcinoma do pulmão (8,54%) e carcinoma das células renais (6,10%). O tempo médio de intervenção cirúrgica para fixação com haste foi 90,16 ± 42,98 minutos (40-135). Todos os pacientes referiram melhoria das queixas álgicas no nível do braço e velicou-se melhoria do score MSTS médio de 26% no pré-operatório para 72,6% na avaliação efetuada nos pacientes ainda vivos aos três meses de pós-operatório. A taxa de sobrevivência aos três meses após a cirurgia foi de 69,50%, 56,10% aos seis meses, 26,70% em um ano e 11,90% em dois anos. Nenhuma das mortes decorreu da cirurgia ou de complicações dela. Apenas se registaram quatro complicações relacionadas com a cirurgia, uma intraoperatória e três tardias, corresponderam a risco de complicações de 4,65%.
Conclusão O uso de haste intramedular não fresada estática bloqueada (anterógrado ou retrógrado) no úmero é um método rápido, seguro, eficaz e com baixa morbilidade no tratamento das fraturas patológicas da diáfise umeral, garante fixação estável do braço e consequentemente melhora a funcionalidade e a qualidade de vida desses pacientes durante a sua curta expectativa de vida.
Changing contribution of peak velocity events to annual velocities following a multi-decadal slowdown at White Glacier
Authors: Thomson Laura I. , Copland Luke 
Published: February 2018

ABSTRACTAs the focus of intensive glaciological studies in the 1960–70s, White Glacier on Axel Heiberg Island, Canada, has played an important role in understanding the dynamics of mostly-cold polythermal glaciers in the high Arctic. In this study, we examine the magnitude, duration and timing of peak velocity events in the summers of 2013–15 using continuous dual-frequency GPS observations, and compare them with similar measurements made in 1968. Summer speed-up events in 1968 and 2014, in which ice velocities reached 200% above winter values, were found to occur in conjunction with formation and drainage of an ice-marginal lake. Despite thinning of the glacier by >20 m and a decrease in annual surface velocities of 15–35% since the 1960s, the relative magnitude and duration of these peak events has increased, particularly at lower elevations, in comparison with the observations at the same locations many decades ago. Given the long-term slowdown of the glacier, the relative contribution of summer displacement to the net annual motion has therefore increased significantly, with summer motion over the span of <2 months now accounting for nearly half of the total annual displacement.
Review of implementation strategies to change healthcare provider behaviour in the emergency department
Authors: de Wit Kerstin , Curran Janet , Thoma Brent , Dowling Shawn , Lang Eddy , Kuljic Nebojsa , Perry Jeffrey J. , Morrison Laurie 
Published: February 2018

AbstractObjectivesAdvances in emergency medicine research can be slow to make their way into clinical care, and implementing a new evidence-based intervention can be challenging in the emergency department. The Canadian Association of Emergency Physicians (CAEP) Knowledge Translation Symposium working group set out to produce recommendations for best practice in the implementation of a new science in Canadian emergency departments.MethodsA systematic review of implementation strategies to change health care provider behaviour in the emergency department was conducted simultaneously with a national survey of emergency physician experience. We summarized our findings into a list of draft recommendations that were presented at the national CAEP Conference 2017 and further refined based on feedback through social media strategies.ResultsWe produced 10 recommendations for implementing new evidence-based interventions in the emergency department, which cover identifying a practice gap, evaluating the evidence, planning the intervention strategy, monitoring, providing feedback during implementation, and desired qualities of future implementation research.ConclusionsWe present recommendations to guide future emergency department implementation initiatives. There is a need for robust and well-designed implementation research to guide future emergency department implementation initiatives.
A DIRECT PROOF OF SCHWICHTENBERG’S BAR RECURSION CLOSURE THEOREM
Authors: OLIVA PAULO , STEILA SILVIA 
Published: February 2018

AbstractIn [12], Schwichtenberg showed that the System T definable functionals are closed under a rule-like version Spector’s bar recursion of lowest type levels 0 and 1. More precisely, if the functional Y which controls the stopping condition of Spector’s bar recursor is T-definable, then the corresponding bar recursion of type levels 0 and 1 is already T-definable. Schwichtenberg’s original proof, however, relies on a detour through Tait’s infinitary terms and the correspondence between ordinal recursion for $\alpha < {\varepsilon _0}$ and primitive recursion over finite types. This detour makes it hard to calculate on given concrete system T input, what the corresponding system T output would look like. In this paper we present an alternative (more direct) proof based on an explicit construction which we prove correct via a suitably defined logical relation. We show through an example how this gives a straightforward mechanism for converting bar recursive definitions into T-definitions under the conditions of Schwichtenberg’s theorem. Finally, with the explicit construction we can also easily state a sharper result: if Y is in the fragment Ti then terms built from $BR^{\mathbb{N},\sigma } $ for this particular Y are definable in the fragment ${T_{i + {\rm{max}}\left\{ {1,{\rm{level}}\left( \sigma \right)} \right\} + 2}}$.
Estimating the number of pulses in a mass extinction
Authors: Wang Steve C. , Zhong Ling 
Published: February 2018

AbstractThe Signor-Lipps effect states that even a sudden mass extinction will invariably appear gradual in the fossil record, due to incomplete fossil preservation. Most previous work on the Signor–Lipps effect has focused on testing whether taxa in a mass extinction went extinct simultaneously or gradually. However, many authors have proposed scenarios in which taxa went extinct in distinct pulses. Little methodology has been developed for quantifying characteristics of such pulsed extinction events. Here we introduce a method for estimating the number of pulses in a mass extinction, based on the positions of fossil occurrences in a stratigraphic section. Rather than using a hypothesis test and assuming simultaneous extinction as the default, we reframe the question by asking what number of pulses best explains the observed fossil record.Using a two-step algorithm, we are able to estimate not just the number of extinction pulses but also a confidence level or posterior probability for each possible number of pulses. In the first step, we find the maximum likelihood estimate for each possible number of pulses. In the second step, we calculate the Akaike information criterion and Bayesian information criterion weights for each possible number of pulses, and then apply ak-nearest neighbor classifier to these weights. This method gives us a vector of confidence levels for the number of extinction pulses—for instance, we might be 80% confident that there was a single extinction pulse, 15% confident that there were two pulses, and 5% confident that there were three pulses. Equivalently, we can state that we are 95% confident that the number of extinction pulses is one or two. Using simulation studies, we show that the method performs well in a variety of situations, although it has difficulty in the case of decreasing fossil recovery potential, and it is most effective for small numbers of pulses unless the sample size is large. We demonstrate the method using a data set of Late Cretaceous ammonites.
Carbon-isotope stratigraphy of the uppermost Cambrian in eastern Laurentia: implications for global correlation
Authors: AZMY KAREM 
Published: February 2018

AbstractThe δ13C profile from an interval of the Martin Point section in western Newfoundland (Canada) spans the upper Furongian (uppermost Cambrian). The interval (~90 m) is a part of the Green Point Formation of the Cow Head Group and consists of the Martin Point (lower) and the Broom Point (upper) members. It is formed of slope marine carbonates alternating with shales (rhythmites) and conglomeratic interbeds. The preservation of the investigated micritic carbonates was meticulously evaluated by multiple petrographic and geochemical screening tools. The δ13C and δ18O values (−0.5 ± 0.8 ‰VPDB and −7.1 ± 0.3 ‰VPDB, respectively) exhibit insignificant correlation (R2= 0.002) and similarly the correlation of δ13C values with their Sr and Mn counterparts, which supports the preservation of at least near-primary δ13C signatures that can be utilized to construct a reliable high-resolution carbon-isotope profile for global correlations.The δ13C profile exhibits two main negative excursions, a lower broad excursion (~3 ‰) that reaches its maximum at ~70 m below the Martin Point / Broom Point members boundary and an upper narrow excursion (~2.5 ‰) immediately below the same boundary. The lower excursion can be correlated with the global latest Furongian HERB event (TOCE), which is also recognized in the C-isotope profile of the GSSP boundary section at Green Point whereas the upper excursion matches with that of the Cambrian‒Ordovician boundary in the same section. The peak of the HERB δ13C excursion is correlated with positive shifts on the Th/U and Ni profiles (redox and productivity proxies).
Do patients with p16-positive oropharyngeal squamous cell carcinoma get more bone metastasis than p16-negative patients?
Authors: Harris A S , Thomas R G , Passant C D 
Published: February 2018

AbstractBackground:Oropharyngeal squamous cell carcinoma is thought to rarely metastasise to bone. This study hypothesised that in p16-positive disease there is a significant incidence of bony metastasis.Methods:This was an ambispective cohort review. All patients with oropharyngeal squamous cell carcinoma diagnosed and treated at one centre were included.Results:A total of 180 consecutive patients were identified over 5 years. Fifteen patients were excluded because of lack of p16 status, none of whom had bony metastasis. The final analysis included 165 patients: 48 (29.09 per cent) in the p16-negative group and 117 (70.91 per cent) in the p16-positive group. Ten patients (8.55 per cent) in the p16-positive group developed bony metastasis, compared with zero in the p16-negative group; this difference was statistically significant (p = 0.036).Conclusion:Expression of p16 was associated with an increased incidence in bony metastasis in this cohort. This is the first study to explore this specific question.
Microbiology and antimicrobial susceptibility of otitis externa: a changing pattern of antimicrobial resistance
Authors: Heward E , Cullen M , Hobson J 
Published: February 2018

AbstractObjective:Otitis externa is a common presentation to secondary care otolaryngology clinics. Despite this, few studies have investigated the microbiology and antimicrobial resistance of otitis externa. This study aimed to examine these issues.Methods:Analysis identified 302 swabs taken from 217 patients (100 male, 117 female), between 1 January 2015 and 30 March 2016, at our rapid access otolaryngology clinic.Results:In total, 315 organisms were isolated; the most frequent was Pseudomonas aeruginosa (31.1 per cent), followed by candida species (22.9 per cent) and Staphylococcus aureus (11.7 per cent). P aeruginosa was sensitive to ciprofloxacin in 97.7 per cent of cases and to gentamicin in 78.4 per cent.Conclusion:Compared with studies worldwide, the relative proportions of different organisms causing otitis externa and the patterns of antimicrobial resistance differ. Increasing resistance of P aeruginosa to aminoglycosides demonstrates a changing pattern of antimicrobial resistance that has not been previously reported. Reassuringly, quinolone antibiotics remain highly effective when treating P aeruginosa.
Integrating collaborative governance theory with the Advocacy Coalition Framework
Authors: Koebele Elizabeth A. 
Published: February 2018

AbstractAs collaborative governance processes continue to grow in popularity, practitioners and policy scholars alike can benefit from the development of methods to better analyse and evaluate them. This article develops one such method by demonstrating how collaborative governance theory can be integrated with the Advocacy Coalition Framework (ACF) to better explain coalition dynamics, policy-oriented learning and policy change in collaborative contexts. I offer three theoretical propositions that suggest alternate relationships among ACF variables under collaborative governance arrangements and illustrate these propositions using interview data from an original case study of a collaborative governance process in Colorado, USA. The integration of collaborative governance theory with the ACF improves its application in collaborative contexts and provides new theoretical insights into the study and practice of collaborative governance.