bluuebunny/crossref_metadata_2025_split huggingface dataset:
Role of Magnetic Resonance Imaging in the Diagnosis of Fetal Brain Anomalies
Authors: Resta Mariachiara , Dicuonzo Franca , Resta Maurizio 
Published: February 2018

ABSTRACT
Prenatal Ultrasonagraphy (US) is the mainstay modality to diagnose fetal abnormalities especially in early pregnancy. Fetal Magnetic Resonance Imaging (MRI) is a useful tool to confirm and to characterize a pathology that is suspected on US, especially in the detection of central nervous system pathologies. The use of ultrafast imaging tecniques gives additional importantant informations and optimal imaging quality, despite fetal motion, in clinical practice.
Diffusion Weighted Imaging (DWI), Diffusion Tensor Imaging (DTI), MR Spetroscopy and Functional studies have potential applications in the fetal brain imaging. Fetal MRI could recognize, in contradistinction to US, the development of fetal brain, the multilayered appearance of the cerebral parenchyma, the timing of sulci development and the myelination.
The most common indications for fetal MRI are ventriculomegaly, midline anomalies, malformations of cerebral cortical development, posterior fossa anomalies, suspected haemorraghic-ischemic lesions, tumors.
Fetal MRI is a safe and powerful complement to US for clinical management and prognostication.

How to cite this article
Resta M, Dicuonzo F, Resta M. Role of Magnetic Resonance Imaging in the Diagnosis of Fetal Brain Anomalies. Donald School J Ultrasound Obstet Gynecol 2017;11(4):328-340.
Transesophageal Echocardiographic Diagnosis and Imaging of Cardiac Situs and Malposition
Authors: Puri Goverdhan D , Ganesh Kumar M , Ganesan Rajarajan 
Published: February 2018

ABSTRACT
Dextrocardia (DC) is a rare cardiac anomaly that can be associated with other congenital abnormalities. Transesophageal echocardiographic imaging for evaluating these patients requires modification of the omniplane angle from the standard angles used. We describe the imaging technique in this condition when it is associated with situs solitus (SS) and situs inversus.

How to cite this article
Kumar MG, Ganesan R, Puri GD. Transesophageal Echocardiographic Diagnosis and Imaging of Cardiac Situs and Malposition. J Perioper Echocardiogr 2017;5(2):64-69.
Evaluation of statistical methods for quantifying fractal scaling in water-quality time series with irregular sampling
Authors: Zhang Qian , Harman Ciaran J. , Kirchner James W. 
Published: February 2018

Abstract. River water-quality time series often exhibit fractal scaling, which here refers to autocorrelation that decays as a power law over some range of scales. Fractal scaling presents challenges to the identification of deterministic trends because (1) fractal scaling has the potential to lead to false inference about the statistical significance of trends and (2) the abundance of irregularly spaced data in water-quality monitoring networks complicates efforts to quantify fractal scaling. Traditional methods for estimating fractal scaling – in the form of spectral slope (β) or other equivalent scaling parameters (e.g., Hurst exponent) – are generally inapplicable to irregularly sampled data. Here we consider two types of estimation approaches for irregularly sampled data and evaluate their performance using synthetic time series. These time series were generated such that (1) they exhibit a wide range of prescribed fractal scaling behaviors, ranging from white noise (β  =  0) to Brown noise (β  =  2) and (2) their sampling gap intervals mimic the sampling irregularity (as quantified by both the skewness and mean of gap-interval lengths) in real water-quality data. The results suggest that none of the existing methods fully account for the effects of sampling irregularity on β estimation. First, the results illustrate the danger of using interpolation for gap filling when examining autocorrelation, as the interpolation methods consistently underestimate or overestimate β under a wide range of prescribed β values and gap distributions. Second, the widely used Lomb–Scargle spectral method also consistently underestimates β. A previously published modified form, using only the lowest 5 % of the frequencies for spectral slope estimation, has very poor precision, although the overall bias is small. Third, a recent wavelet-based method, coupled with an aliasing filter, generally has the smallest bias and root-mean-squared error among all methods for a wide range of prescribed β values and gap distributions. The aliasing method, however, does not itself account for sampling irregularity, and this introduces some bias in the result. Nonetheless, the wavelet method is recommended for estimating β in irregular time series until improved methods are developed. Finally, all methods' performances depend strongly on the sampling irregularity, highlighting that the accuracy and precision of each method are data specific. Accurately quantifying the strength of fractal scaling in irregular water-quality time series remains an unresolved challenge for the hydrologic community and for other disciplines that must grapple with irregular sampling.
Inflammatory cell populations in early neuroinflammation in the core and peri-ischemic lesions of rat brain after transient focal cerebral ischemia: A morphometric study
Authors: Horvath Emoke , Oradan Alex , Chiriac Liviu , Dobreanu Minodora , Nagy Előd-Ernő , Hutanu Adina 
Published: February 2018

Background and Objective: Clinical and experimental observations emphasize the role of inflammation as a direct risk factor for stroke. To better characterize the inflammation, we have conducted a detailed histological analysis of the inflammatory cell population after transient middle cerebral artery occlusion in a rat model.
Methods: Fifteen adult Wistar male rats were divided randomly into test (n=10) and sham (n=5) groups. In the ischemic group, transient focal cerebral ischemia was induced with an intraluminal filament technique. Histologic lesions of the ischemic core and the surrounding penumbra zone were evaluated, based on a complex algorithm. Representative morphological changes in the core and the penumbra zone were compared. Immunohistochemistry was performed for leukocytes markers (CD15, CD68, CD3), leukocyte-released effectors (MMP-9 and COX-2), and FXIII (possibly involved in microglia and macrophage activation)
Results: Neuronal vacuolation and degeneration were significantly more in the core lesion, whereas cellular edema and inflammatory infiltrate were increased in the penumbra. CD68, CD3, FXIII and Cox-2 expression were significantly higher in the penumbra than in the core (p=0.026; p=0.006; p=0.002; and p<0.001).
Discussion: In the rat model of middle cerebral artery occlusion, inflammatory mechanisms, microglia/macrophage cells, and T-lymphocytes likely play an important role in the penumbra. The deterioration of neurons is less in the penumbra than in the core. Appreciation of the role of the inflammatory cells and mechanisms involved in stroke might lead to measures to inhibit the injury and save brain volume.
Understanding D-Ribose and Mitochondrial Function
Authors: Mahoney Diane E. , Hiebert John B. , Thimmesch Amanda , Pierce John T. , Vacek James L. , Clancy Richard L. , Sauer Andrew J. , Pierce Janet D. 
Published: February 2018

Mitochondria are important organelles referred to as cellular powerhouses for their unique properties of cellular energy production. With many pathologic conditions and aging, mitochondrial function declines, and there is a reduction in the production of adenosine triphosphate. The energy carrying molecule generated by cellular respiration and by pentose phosphate pathway, an alternative pathway of glucose metabolism. D-ribose is a naturally occurring monosaccharide found in the cells and particularly in the mitochondria is essential in energy production. Without sufficient energy, cells cannot maintain integrity and function. Supplemental D-ribose has been shown to improve cellular processes when there is mitochondrial dysfunction. When individuals take supplemental D-ribose, it can bypass part of the pentose pathway to produce D-ribose-5-phosphate for the production of energy. In this article, we review how energy is produced by cellular respiration, the pentose pathway, and the use of supplemental D-ribose.
An observational study on risk of secondary cancers in chronic myeloid leukemia patients in the TKI era in the United States
Authors: Kumar Vivek , Garg Mohit , Chaudhary Neha , Chandra Abhinav Binod 
Published: February 2018

IntroductionThe treatment with tyrosine kinase inhibitors (TKIs) has drastically improved the outcome of chronic myeloid leukemia (CML) patients. This study was conducted to examine the risk of secondary cancers (SCs) in the CML patients who were diagnosed and treated in the TKI era in the United States.MethodsThe surveillance epidemiology and end results (SEER) database was used to identify CML patients who were diagnosed and received treatment during January 2002–December 2014. Standardized incidence ratios (SIRs) and absolute excess risks (AER) were calculated.ResultsOverall, 511 SCs (excluding acute leukemia) developed in 9,200 CML patients followed for 38,433 person-years. The risk of developing SCs in the CML patients was 30% higher than the age, sex and race matched standard population (SIR 1.30, 95% CI: 1.2–1.40;p< 0.001). The SIRs for CLL (SIR 3.4, 95% CI: 2–5.5;p< 0.001), thyroid (SIR 2.2, 95% CI: 1.2–3.5;p< 0.001), small intestine (SIR 3.1, 95% CI: 1.1–7;p= 0.004), gingiva (SIR 3.7, 95% CI: 1.2–8.7;p= 0.002), stomach (SIR 2.1, 95% CI: 1.1–3.5;p= 0.005), lung (SIR 1.4, 95% CI: 1.1–1.7;p= 0.006) and prostate (SIR 1.3, 95% CI: 1.02–1.6;p= 0.026) cancer among CML patients were significantly higher than the general population. The risk of SCs was higher irrespective of age and it was highest in the period 2–12 months after the diagnosis of CML. The risk of SCs in women was similar to that of the general population.ConclusionCML patients diagnosed and treated in the TKI era in the United States are at an increased risk of developing a second malignancy. The increased risk of SCs in the early period after CML diagnosis suggests that the risk of SCs may be increased due to the factors other than TKIs treatment.
Compiling and Mapping Global Permeability of the Unconsolidated and Consolidated Earth: GLobal HYdrogeology MaPS 2.0 (GLHYMPS 2.0)
Authors: Huscroft Jordan , Gleeson Tom , Hartmann Jens , Börker Janine 
Published: February 2018

AbstractThe spatial distribution of subsurface parameters such as permeability are increasingly relevant for regional to global climate, land surface, and hydrologic models that are integrating groundwater dynamics and interactions. Despite the large fraction of unconsolidated sediments on Earth's surface with a wide range of permeability values, current global, high‐resolution permeability maps distinguish solely fine‐grained and coarse‐grained unconsolidated sediments. Representative permeability values are derived for a wide variety of unconsolidated sediments and applied to a new global map of unconsolidated sediments to produce the first geologically constrained, two‐layer global map of shallower and deeper permeability. The new mean logarithmic permeability of the Earth's surface is −12.7 ± 1.7 m2 being 1 order of magnitude higher than that derived from previous maps, which is consistent with the dominance of the coarser sediments. The new data set will benefit a variety of scientific applications including the next generation of climate, land surface, and hydrology models at regional to global scales.
Evidence for Diverse Biogeochemical Drivers of Boreal Forest New Particle Formation
Authors: Lawler Michael J. , Rissanen Matti P. , Ehn Mikael , Mauldin R. Lee , Sarnela Nina , Sipilä Mikko , Smith James N. 
Published: February 2018

AbstractNew particle formation (NPF) is an important contributor to particle number in many locations, but the chemical drivers for this process are not well understood. Daytime NPF events occur regularly in the springtime Finnish boreal forest and strongly impact aerosol abundance. In April 2014 size‐resolved chemical measurements of ambient nanoparticles were made using the Time‐of‐Flight Thermal Desorption Chemical ionization Mass Spectrometer and we report results from two NPF events. While growth overall was dominated by terpene oxidation products, newly formed 20–70 nm particles showed enhancement in apparent alkanoic acids. The events occurred on days with rapid transport of marine air, which correlated with low background aerosol loading and higher gas phase methanesulfonic acid levels. These results are broadly consistent with previous studies on Nordic NPF but indicate that further attention should be given to the sources and role of non‐terpenoid organics and the possible contribution of transported marine compounds in this process.
Constraints on Transient Viscoelastic Rheology of the Asthenosphere From Seasonal Deformation
Authors: Chanard Kristel , Fleitout Luce , Calais Eric , Barbot Sylvain , Avouac Jean‐Philippe 
Published: February 2018

AbstractWe discuss the constraints on short‐term asthenospheric viscosity provided by seasonal deformation of the Earth. We use data from 195 globally distributed continuous Global Navigation Satellite System stations. Surface loading is derived from the Gravity Recovery and Climate Experiment and used as an input to predict geodetic displacements. We compute Green's functions for surface displacements for a purely elastic spherical reference Earth model and for viscoelastic Earth models. We show that a range of transient viscoelastic rheologies derived to explain the early phase of postseismic deformation may induce a detectable effect on the phase and amplitude of horizontal displacements induced by seasonal loading at long wavelengths (1,300–4,000 km). By comparing predicted and observed seasonal horizontal motion, we conclude that transient asthenospheric viscosity cannot be lower than 5 × 1017 Pa.s, suggesting that low values of transient asthenospheric viscosities reported in some postseismic studies cannot hold for the seasonal deformation global average.
A “Geodetic Gap” in the Calabrian Arc: Evidence for a Locked Subduction Megathrust?
Authors: Carafa M. M. C. , Kastelic V. , Bird P. , Maesano F. E. , Valensise G. 
Published: February 2018

AbstractSubduction of old Ionian seafloor beneath the Calabrian Arc (southern Italy) is the geological process with the greatest mass flux in the central Mediterranean, yet its seismogenic behavior is largely obscured. No unambiguous evidence of subduction‐related earthquakes exists in historical times, and local GPS velocities indicate very low strain rates. Nevertheless, the region hosted some of the deadliest normal‐faulting earthquakes of the entire Mediterranean basin. We show that the low strain rates recorded in southern Calabria can be reconciled with the regional vigorous seismic moment release by assuming high interseismic coupling but low seismic coupling of the subduction interface. The alternative scenario of steadily creeping subduction cannot be ruled out but requires the historical seismicity record to be dismissed as unrepresentative. We refer to the peculiar spatial pattern of short‐term strain rates in southern Calabria as a “geodetic gap” resulting from destructive interference between upper‐plate extension and temporary compression due to locking along the subduction interface. Seismic hazard modelers must understand that within such gaps, the long‐term seismic hazard is greater than that suggested by the low geodetic strain rates.
Physical Explanation of Archie's Porosity Exponent in Granular Materials: A Process‐Based, Pore‐Scale Numerical Study
Authors: Niu Qifei , Zhang Chi 
Published: February 2018

AbstractThe empirical Archie's law has been widely used in geosciences and engineering to explain the measured electrical resistivity of many geological materials, but its physical basis has not been fully understood yet. In this study, we use a pore‐scale numerical approach combining discrete element‐finite difference methods to study Archie's porosity exponent m of granular materials over a wide porosity range. Numerical results reveal that at dilute states (e.g., porosity ϕ > ~65%), m is exclusively related to the particle shape and orientation. As the porosity decreases, the electric flow in pore space concentrates progressively near particle contacts and m increases continuously in response to the intensified nonuniformity of the local electrical field. It is also found that the increase in m is universally correlated with the volume fraction of pore throats for all the samples regardless of their particle shapes, particle size range, and porosities.
Origin of Methane and Sources of High Concentrations in Los Angeles Groundwater
Authors: Kulongoski J. T. , McMahon P. B. , Land M. , Wright M. T. , Johnson T. A. , Landon M. K. 
Published: February 2018

AbstractIn 2014, samples from 37 monitoring wells at 17 locations, within or near oil fields, and one site >5 km from oil fields, in the Los Angeles Basin, California, were analyzed for dissolved hydrocarbon gas isotopes and abundances. The wells sample a variety of depths of an aquifer system composed of unconsolidated and semiconsolidated sediments under various conditions of confinement. Concentrations of methane in groundwater samples ranged from 0.002 to 150 mg/L—some of the highest concentrations reported in a densely populated urban area. The δ13C and δ2H of the methane ranged from −80.8 to −45.5 per mil (‰) and −249.8 to −134.9‰, respectively, and, along with oxidation‐reduction processes, helped to identify the origin of methane as microbial methanogenesis and CO2 reduction as its main formation pathway. The distribution of methane concentrations and isotopes is consistent with the high concentrations of methane in Los Angeles Basin groundwater originating from relatively shallow microbial production in anoxic or suboxic conditions. Source of the methane is the aquifer sediments rather than the upward migration or leakage of thermogenic methane associated with oil fields in the basin.
Relative Influence of Timing and Accumulation of Snow on Alpine Land Surface Phenology
Authors: Xie Jing , Kneubühler Mathias , Garonna Irene , de Jong Rogier , Notarnicola Claudia , De Gregorio Ludovica , Schaepman Michael E. 
Published: February 2018

AbstractTiming and accumulation of snow are among the most important phenomena influencing land surface phenology in mountainous ecosystems. However, our knowledge on their influence on alpine land surface phenology is still limited, and much remains unclear as to which snow metrics are most relevant for studying this interaction. In this study, we analyzed five snow and phenology metrics, namely, timing (snow cover duration (SCD) and last snow day), accumulation of snow (mean snow water equivalent, SWEm), and mountain land surface phenology (start of season and length of season) in the Swiss Alps during the period 2003–2014. We examined elevational and regional variations in the relationships between snow and alpine land surface phenology metrics using multiple linear regression and relative weight analyses and subsequently identified the snow metrics that showed strongest associations with variations in alpine land surface phenology of natural vegetation types. We found that the relationships between snow and phenology metrics were pronounced in high‐elevational regions and alpine natural grassland and sparsely vegetated areas. Start of season was influenced primarily by SCD, secondarily by SWEm, while length of season was equally affected by SCD and SWEm across different elevational bands. We conclude that SCD plays the most significant role compared to other snow metrics. Future variations of snow cover and accumulation are likely to influence alpine ecosystems, for instance, their species composition due to changes in the potential growing season. Also, their spatial distribution may change as a response to the new environmental conditions if these prove persistent.
Necromass as a Limited Source of Energy for Microorganisms in Marine Sediments
Authors: Bradley James A. , Amend Jan P. , LaRowe Douglas E. 
Published: February 2018

AbstractThe in situ production of necromass and its role as a power source in sustaining heterotrophic microorganisms in marine sediments has never been quantified. Here we quantify the power availability from necromass oxidation to living microorganisms buried in marine sediments over millions of years, first in the oligotrophic South Pacific Gyre (SPG) and second on a global scale. We calculate that power from autochthonously produced necromass in the upper meter of sediment underlying SPG provides only a small fraction (~0.02%) of the maintenance power demand of the living community (1.9 × 10−19 W cell−1). Power from necromass oxidation diminishes considerably with increasing sediment depth (and thus sediment age). Alternatively, the oxidation of allochthonous organic matter, and of radiolytic H2, provides power equivalent to or in excess of the maintenance demands of living microorganisms at SPG. On a global scale, necromass may support the maintenance power demand of 2 to 13% of the microbial community in relatively young sediments (<10,000 years) when it is oxidized with SO42− and O2, respectively. However, in older sediments, the power supplied by necromass is negligible (<0.01%). Nevertheless, the oxidation of a single dead cell per year provides sufficient power to support the maintenance demands of dozens to thousands of cells in low‐energy marine sediments. This raises the possibility that the production and oxidation of necromass may provide a mechanism for non‐growing microorganisms to endure unfavorable, low‐energy settings over geological timescales.
Seasonal Surface Loading Helps Constrain Short‐Term Viscosity of the Asthenosphere
Authors: Clarke Peter J. 
Published: February 2018

AbstractEarth materials may display a range of rheological behaviors at different depths and over different timescales. The situation is particularly complex for postseismic relaxation in the uppermost mantle and lower crust, where it can be difficult to distinguish widespread viscous behavior from earthquake afterslip or localized deformation in shear zones over timescales of weeks to decades. By analyzing geodetic observations of seasonal surface mass loads and Earth's surface deformation in response, Chanard et al. (2018, https://doi.org/10.1002/2017GL076451) have established a globally averaged lower bound of 5 × 1017 Pa s for the transient viscosity of a Burgers‐rheology asthenosphere. This implies that lower viscosities inferred by some studies of postseismic relaxation must result from local departures from this global value, or be an artifact of additional afterslip or shear zone deformation.
Peptide Amphiphile Nanostructures for Targeting of Atherosclerotic Plaque and Drug Delivery
Authors: So Miranda M. , Mansukhani Neel A. , Peters Erica B. , Albaghdadi Mazen S. , Wang Zheng , Rubert Pérez Charles M. , Kibbe Melina R. , Stupp Samuel I. 
Published: February 2018

AbstractCoassembled peptide amphiphile nanofibers designed to target atherosclerotic plaque and enhance cholesterol efflux are shown to encapsulate and deliver a liver X receptor agonist to increase efflux from murine macrophages in vitro. Fluorescence microscopy reveals that the nanofibers, which display an apolipoprotein‐mimetic peptide, localize at plaque sites in low density lipoprotein receptor knockout (LDLR KO) mice with or without the encapsulated molecule, while nanofibers displaying a scrambled, nontargeting peptide sequence do not demonstrate comparable binding. These results show that nanofibers functionalized with apolipoprotein‐mimetic peptides may be effective vehicles for intravascular targeted drug delivery to treat atherosclerosis.