bluuebunny/crossref_metadata_2025_split huggingface dataset:
Improved treatment satisfaction in patients with type 2 diabetes treated with once‐weekly semaglutide in the SUSTAIN trials
Authors: Jendle Johan , Birkenfeld Andreas L. , Polonsky William H. , Silver Robert , Uusinarkaus Kari , Hansen Thomas , Håkan‐Bloch Jonas , Tadayon Sayeh , Davies Melanie J. 
Published: June 2019

AbstractAimTo investigate treatment satisfaction with semaglutide, a once‐weekly glucagon‐like peptide‐1 receptor agonist, versus placebo/active comparators in the SUSTAIN clinical trial programme.MethodsIn SUSTAIN 2–5 and 7, the Diabetes Treatment Satisfaction Questionnaire was used to evaluate patient‐perceived treatment satisfaction, hyperglycaemia and hypoglycaemia. Post hoc subgroup analyses were conducted to explore the effects of gastrointestinal adverse events (GI AEs), weight loss (≥5%) or achieving glycaemic (HbA1c < 7%) targets on treatment satisfaction.ResultsOverall treatment satisfaction increased from baseline to end of treatment with all treatments across trials. Improvements were significantly greater with semaglutide versus comparators/placebo in SUSTAIN 2–5 (all P < 0.05), and generally greater in patients who achieved versus did not achieve weight loss and glycaemic targets, often with greater improvements with semaglutide 1.0 mg versus comparator/placebo in both weight loss groups. In SUSTAIN 7, improvements in overall treatment satisfaction were generally similar between semaglutide and dulaglutide, irrespective of weight loss or glycaemic control. In SUSTAIN 7, changes in overall treatment satisfaction score were generally lower in patients with versus without GI AEs at week 16 (except dulaglutide 0.75 mg), but similar by week 40. Perceived hyperglycaemia was significantly reduced from baseline to end of treatment with semaglutide versus all comparators/placebo (all P < 0.05). No differences between treatments were observed for perceived hypoglycaemia.ConclusionsSemaglutide was associated with significantly greater (SUSTAIN 2–5) or similar (SUSTAIN 7) improvements in overall treatment satisfaction versus comparators/placebo. Improvements in overall treatment satisfaction were generally greater in patients achieving versus not achieving treatment targets.
Clinicaltrials.gov: NCT01930188 (SUSTAIN 2), NCT01885208 (SUSTAIN 3), NCT02128932 (SUSTAIN 4), NCT02305381 (SUSTAIN 5) and NCT02648204 (SUSTAIN 7).EudraCT: 2012–004827‐19 (SUSTAIN 2), 2012–004826‐92 (SUSTAIN 3), 2013–004392‐12 (SUSTAIN 4), 2013–004502‐26 (SUSTAIN 5) and 2014–005375‐91 (SUSTAIN 7).
Native valve endocarditis due to Candida albicans in two children: Two new case reports
Authors: Guner Gizem , Bal Zumrut Sahbudak , Dogan Eser , Umit Zuhal , Levent Erturk , Hilmioglu Polat Suleyha , Ozkinay Ferda , Kurugol Zafer 
Published: June 2019

AbstractCandida endocarditis (CE) is a rare and serious complication of candidemia. Using current diagnostic tools a confirmed diagnosis is often delayed and outcomes remain poor. The majority of new cases occur following cardiac valvular surgery, and/or in patients with the following risk factors: intravenous drug use, cancer chemotherapy, prolonged presence of central venous catheters, and prior history of bacterial endocarditis. It is not a common complication in non‐neutropenic patients particularly with the absence of a prosthetic valve, and very few reports in the literature are available. Attempting to add to the limited data, 211 candidemia episodes from 172 nonneutropenic pediatric cases between January 2008 and December 2017 were evaluated. All patients were considered asymptomatic for underlying heart disease. However, 2 (0.9%) patients with a central venous catheter were determined as having endocarditis following echocardiography.
First report of the lacebug Corythauma ayyari (Drake) (Hemiptera: Tingidae) on Jasminum grandiflorum L. and Jasminum sambac (L.) from Syria
Authors: Zeity M. , Ali A. Y. 
Published: June 2019

AbstractIn Syria, defoliation was noted on several Jasminum grandiflorum and Jasminum sambac plants in various gardens in Latakia City and countryside in 2017. Subsequently, several male and female specimens of a lacebug insect were collected from the white jasmine, Jasminum grandiflorum, planted in the garden of the Latakia Center for Agricultural Research during 2018. Collected material was examined and identified as Corythauma ayyari (Drake). Infestation by this insect is considered by the authors to cause the defoliation of jasmine plants in Latakia City and it is reported to occur in Syria for the first time.
Combined impacts of warming and salinisation on trophic interactions and mortality of a specialist ephemeral wetland predator
Authors: Cuthbert Ross N. , Weyl Olaf L. F. , Wasserman Ryan J. , Dick Jaimie T. A. , Froneman P. William , Callaghan Amanda , Dalu Tatenda 
Published: June 2019

AbstractWetlands are of enormous importance for biodiversity globally but are under increasing risk from multiple stressors driven by ongoing anthropogenic environmental change. As the trophic structure and dynamics of ephemeral wetlands are poorly understood, it is difficult to predict how these biodiverse ecosystems will be impacted by global change. In particular, warming and salinisation are projected to have profound impacts on these wetlands in future.The present study examined the combined effects of warming and salinisation on species interaction strengths and mortality rates for two ephemeral wetland species. Using an ephemeral pond specialist copepod,Lovenula rayneraeSuárez‐Morales, Wasserman, & Dalu, (2015) as a model predator species, we applied a functional response approach to derive warming and salinisation effects on trophic interactions with a prey species. Furthermore, the effects of a salinisation gradient on mortality rates of adult copepods were quantified.The predatory copepod exhibited typeIIfunctional responses towards larvalCulex pipiensmosquito prey, owing to high predation rates at low prey densities. Increased temperatures generally resulted in greater predator feeding rates, whilst increased salinities reduced consumption. However, the effects of temperature and salinity interacted: temperature effects on functional responses were suppressed under heightened salinities. Substantial mortality was observed in both male and female adultL. rayneraeat salinity levels exceeding 10 parts per thousand.Warming and salinisation substantially altered interaction strengths in ephemeral wetland ecosystems, with implications for ecosystem function and stability. Furthermore, we demonstrated salinisation thresholds for mortality in an ephemeral wetland specialist, showing that salinisation may threaten the persistence of endemic species. The ongoing effects of warming and salinisation may therefore interact to alter trophic dynamics and species composition in ephemeral wetlands. These stressors should be considered synergistically within management practices.
Loss of CELF6 RNA binding protein impairs cocaine conditioned place preference and contextual fear conditioning
Authors: Maloney Susan E. , Rieger Michael A. , Al‐Hasani Ream , Bruchas Michael R. , Wozniak David F. , Dougherty Joseph D. 
Published: June 2019

AbstractIn addition to gene expression differences in distinct cell types, there is substantial post‐transcriptional regulation driven in part by RNA binding proteins (RBPs). Loss‐of‐function RBP mutations have been associated with neurodevelopmental disorders, such as Fragile‐X syndrome and syndromic autism. Work performed in animal models to elucidate the influence of neurodevelopmental disorder‐associated RBPs on distinct behaviors has showed a connection between normal post‐transcriptional regulation and conditioned learning. We previously reported cognitive inflexibility in a mouse model null for the RBP CUG‐BP, Elav‐like factor 6 (CELF6), which we also found to be associated with human autism. Specifically, these mice failed to potentiate exploratory hole‐poking behavior in response to familiarization to a rewarding stimuli. Characterization of Celf6 gene expression showed high levels in monoaminergic populations such as the dopaminergic midbrain populations. To better understand the underlying behavioral disruption mediating the resistance to change exploratory behavior in the holeboard task, we tested three hypotheses: Does Celf6 loss lead to global restricted patterns of behavior, failure of immediate response to reward or failure to alter behavior in response to reward (conditioning). We found the acute response to reward was intact, yet Celf6 mutant mice exhibited impaired conditioned learning to both reward and aversive stimuli. Thus, we found that the resistance to change by the Celf6 mutant in the holeboard was most parsimoniously explained as a failure of conditioning, as the mice had blunted responses even to potent rewarding stimuli such as cocaine. These findings further support the role of RBPs in conditioned learning.
Wildfire refugia in forests: Severe fire weather and drought mute the influence of topography and fuel age
Authors: Collins Luke , Bennett Andrew F. , Leonard Steve W. J. , Penman Trent D. 
Published: June 2019

AbstractWildfire refugia (unburnt patches within large wildfires) are important for the persistence of fire‐sensitive species across forested landscapes globally. A key challenge is to identify the factors that determine the distribution of fire refugia across space and time. In particular, determining the relative influence of climatic and landscape factors is important in order to understand likely changes in the distribution of wildfire refugia under future climates. Here, we examine the relative effect of weather (i.e. fire weather, drought severity) and landscape features (i.e. topography, fuel age, vegetation type) on the occurrence of fire refugia across 26 large wildfires in south‐eastern Australia. Fire weather and drought severity were the primary drivers of the occurrence of fire refugia, moderating the effect of landscape attributes. Unburnt patches rarely occurred under ‘severe’ fire weather, irrespective of drought severity, topography, fuels or vegetation community. The influence of drought severity and landscape factors played out most strongly under ‘moderate’ fire weather. In mesic forests, fire refugia were linked to variables that affect fuel moisture, whereby the occurrence of unburnt patches decreased with increasing drought conditions and were associated with more mesic topographic locations (i.e. gullies, pole‐facing aspects) and vegetation communities (i.e. closed‐forest). In dry forest, the occurrence of refugia was responsive to fuel age, being associated with recently burnt areas (<5 years since fire). Overall, these results show that increased severity of fire weather and increased drought conditions, both predicted under future climate scenarios, are likely to lead to a reduction of wildfire refugia across forests of southern Australia. Protection of topographic areas able to provide long‐term fire refugia will be an important step towards maintaining the ecological integrity of forests under future climate change.
Environmental variability shapes evolution, plasticity and biogeographic responses to climate change
Authors: Buckley Lauren B. , Kingsolver Joel G. 
Published: June 2019

AbstractAimWe examine how environmental variability at seasonal and interannual time‐scales influences evolutionary trajectories and the role of plasticity in response to recent and future climate change at biogeographic scales. We investigate the interplay of selection pressures at chronic (performance) and acute (thermal stress) time‐scales.LocationColorado, USA.Time period1950–2099.Major taxa studiedA montane butterfly, clouded sulphur (Colias eriphyle W.H. Edwards, 1876).MethodsWe leverage field and laboratory data to construct phenotype‐based models that predict fitness and evolutionary responses to recent and future climate change. Our focal phenotype, wing solar absorptivity, responds plastically to developmental (pupal) temperatures and determines adult fitness via its influence on body temperature.ResultsWe project that phenology accelerates with decreasing elevation and climate change, but gradients in pupal and adult temperature with climate change are modest. Fitness of the first generation is predicted to decrease at low elevations and increase at high elevations with warming. Elevational clines in optimal wing absorptivity shift towards lower absorptivities with warming. We project that temporal shifts from selection for wing darkening (to extend flight time) to selection for wing lightening (to avoid overheating) in some cool, montane locations will ultimately impose fitness costs.Main conclusionsOur analysis suggests that shifts in the balance of selection between acute and chronic responses to environmental variation will alter biogeographic responses to climate change. Evolutionary lags may ultimately confer greater sensitivity to climate change, but plasticity can reduce evolutionary lags by facilitating trait evolution.
Expanding the clinical spectrum of dermal hyperneury: report of nine new cases and a review of the literature
Authors: Ieremia Eleni , Marušić Zlatko , Mudaliar Vivek , Kelly Susan , Gonzalvo Rodriguez Pablo , McNiff Jennifer M , LeBoit Philip E , Calonje Eduardo 
Published: June 2019

AimsDermal hyperneury is defined as the hypertrophy of small nerves in the dermis. It has been described in a variety of settings. We present a series of nine new cases with a distinctive clinical presentation and review the existing literature. The aim of the study was to summarise the clinical, histopathological and immunohistochemical findings in a case series of dermal hyperneury with unique clinical presentation.Methods and resultsNine cases were identified from the referral practice of one of the authors. Clinical characteristics, including demographic details, were collated. The histopathological features and novel immunohistochemical findings were analysed. Four cases presented with multiple skin lesions. Clinical evaluation revealed no associated syndromic stigmata. The histology in all cases was that of dermal hyperneury. Immunohistochemistry for phosphatase and tensin homologue (PTEN) and RET was supportive of the lack of syndromic association.ConclusionThe presentation of dermal hyperneury with multiple cutaneous lesions and no syndromic associations is distinctive, and no study with PTEN and RET immunohistochemistry has previously been reported. Comparisons with recent reports of multiple non‐syndromic mucocutaneous neuromas are discussed.
Sleep duration and bedtime in preschool‐age children with obesity: Relation to BMI and diet following a weight management intervention
Authors: Simon Stacey L. , Goetz Amy R. , Meier Maxene , Brinton John , Zion Cynthia , Stark Lori J. 
Published: June 2019

SummaryBackgroundSleep duration is associated with obesity in preschoolers. Weight‐management interventions may be an opportunity to incorporate sleep health recommendations.ObjectivesTo examine changes in sleep in preschool‐age children with obesity following a family‐based weight‐management intervention (Learning about Activity and Understanding Nutrition for Child Health [LAUNCH]) compared with motivational interviewing and standard care conditions. Additionally, we examined associations between sleep with body mass index (BMI) z score (BMIz) and diet.MethodsOne hundred fifty‐one children (4.6 ± 0.93 y) completed baseline (pretreatment) and posttreatment (week 24) assessments, including anthropometrics, 24‐hour dietary recalls, and a 7‐day sleep diary. Analysis of variance (ANOVA) and chi‐squared tests compared sleep variables between groups; linear regression models examined effects of sleep on BMIz and dietary intake at posttreatment, controlling for baseline values.ResultsBedtime and sleep duration were not significantly different between treatment groups from baseline to posttreatment. After adjusting for baseline sleep, earlier bedtime was associated with lower BMIz (95% CI, 0.00‐0.04; .03), intake of added sugars (95% CI, 0.70‐4.32; .007), and sweet/dessert food servings (95% CI, 0.00‐0.19; .04) at posttreatment. Longer night‐time sleep duration was associated with fewer added sugars at posttreatment, adjusting for baseline sleep (95% CI, −3.79 to −0.35; .02).ConclusionsMore comprehensive sleep intervention incorporated into weight‐management intervention may be necessary to promote positive changes for preschoolers with obesity. A focus on earlier bedtime and longer sleep duration appears to be important given associations between sleep duration and bedtime with BMIz and dietary intake.
Making Space, Offering Voice
Authors: Spies Miriam 
Published: June 2019

AbstractBy looking closely at the biblical narrative of the man born blind (John 9:1‐41), this article raises how Jesus enables and promotes the participation and, even more so, the leadership of people with disabilities in God’s transformative mission in the church and the world. Through examining each scene in the story through a disability lens, this article aims to challenge the church on how it views leaders with disabilities in God's mission, making space for our voices and our witness as disciples of Christ.
People with Disabilities – In Order to Belong, They Need to Be Missed!
Authors: Naudé John 
Published: June 2019

AbstractPeople with disabilities are often excluded within our churches: Why is that so? This paper will explore why disabled people are not missed within our churches as a mission group and as a member of the body of Christ. It will also explore why the fact that they are not missed makes them feel like they do not belong in the church. The paper will conclude with what people with disabilities have to offer the church, and what the church can positively do to help them feel like they belong through our mission and inclusion of them into the full ministry of the church.
The benefit of native uniqueness in a local red cattle breed from Northern Germany
Authors: Schäler Jonas , Hinrichs Dirk , Thaller Georg 
Published: June 2019

AbstractDuring last decades, native uniqueness decreased in local livestock breeds due to the introgression of high‐yielding breeds. Recovery of native uniqueness became important because of conservation aspects regarding native genetic diversity and native traits. Thereby the expectation exists, that the relation between native uniqueness and genetic gain is contradictory. The aim of this study was to explore the influence of native uniqueness on performance traits and the total merit index in a local red cattle breed from Northern Germany. Data contained a pedigree file of 178,255 Red Dual‐Purpose cattle, 809 target genotypes and 3,581 reference genotypes from introgressed breeds. Native genetic contributions were tested for correlation with performance traits of milk yield, longevity, foundation, somatic cells, fertility and maternal calving and the total merit index. The study revealed that native uniqueness is favourably related to longevity (0.16), foundation (0.23), and somatic cells (0.08), and the total merit index (0.10). Selection on native uniqueness could probably lead to an increased longevity, udder health and genetic gain of the Red Dual‐Purpose cattle. Moreover, it was shown that the Red Dual‐Purpose cattle was not upgraded through introgression of high‐yielding breeds.
Metabolic signature associated with parameters of the complete blood count in apparently healthy individuals
Authors: Masuch Annette , Budde Kathrin , Kastenmüller Gabi , Artati Anna , Adamski Jerzy , Völzke Henry , Nauck Matthias , Pietzner Maik 
Published: June 2019

AbstractMetabolomics studies now approach large sample sizes and the health characterization of the study population often include complete blood count (CBC) results. Upon careful interpretation the CBC aids diagnosis and provides insight into the health status of the patient within a clinical setting. Uncovering metabolic signatures associated with parameters of the CBC in apparently healthy individuals may facilitate interpretation of metabolomics studies in general and related to diseases. For this purpose 879 subjects from the population‐based Study of Health in Pomerania (SHIP)‐TREND were included. Using metabolomics data resulting from mass‐spectrometry based measurements in plasma samples associations of specific CBC parameters with metabolites were determined by linear regression models. In total, 118 metabolites significantly associated with at least one of the CBC parameters. Strongest associations were observed with metabolites of heme degradation and energy production/consumption. Inverse association seen with mean corpuscular volume and mean corpuscular haemoglobin comprised metabolites potentially related to kidney function. The presently identified metabolic signatures are likely derived from the general function and formation/elimination of blood cells. The wealth of associated metabolites strongly argues to consider CBC in the interpretation of metabolomics studies, in particular if mutual effects on those parameters by the disease of interest are known.
Antecedents of attachment states of mind in normative‐risk and high‐risk caregiving: cross‐race and cross‐sex generalizability in two longitudinal studies
Authors: Haltigan John D. , Roisman Glenn I. , Groh Ashley M. , Holland Ashley S. , Booth‐LaForce Cathryn , Rogosch Fred A. , Cicchetti Dante 
Published: June 2019

BackgroundLongitudinal investigations of relatively large typical‐risk (e.g., Booth‐LaForce & Roisman, 2014) and higher‐risk samples (e.g., Raby et al., 2017; Roisman et al., 2017) have produced evidence consistent with the claim that attachment states of mind in adolescence and young adulthood, as measured by the Adult Attachment Interview (AAI), are associated with the quality of caregiving experienced during childhood. None of these studies, however, has examined whether such associations are consistent across sex and/or race, as would be expected in light of the sensitivity hypothesis of attachment theory.MethodsWe examine whether sex or race moderates previously reported links between caregiving and AAI states of mind in two longitudinal studies (pooled N = 1,058) in which caregiving was measured either within (i.e., observed [in]sensitive care) or outside (i.e., childhood maltreatment) of the normative range of caregiving experiences.ResultsHierarchical moderated regression analyses in both longitudinal cohorts provided evidence that maternal insensitivity and experiences of maltreatment were prospectively associated with dismissing and preoccupied states of mind in adolescence, as hypothesized. Moreover, these associations were generally comparable in magnitude for African American and White/non‐Hispanic participants and were not conditional on participants’ biological sex.ConclusionsBoth maternal insensitivity and the experience of maltreatment increased risk for insecure attachment states of mind in adolescence. Moreover, our analyses provided little evidence that either participant race or participant sex assigned at birth moderated these nontrivial associations between measures of the quality of experienced caregiving and insecure attachment states of mind in adolescence. These findings provide support for the sensitivity hypothesis of attachment theory and inform the cultural universality hypothesis of attachment processes.