bluuebunny/crossref_metadata_2025_split huggingface dataset:
QUALITY MANAGEMENT SYSTEM OF A PHARMACEUTICAL ORGANIZATION: CRITERIA AND IMPLEMENTATION
Authors: Klimenkova A. A. , Geller L. N. , Skripko A. A. , Gravchenko L. A. , Fedorenko N. V. 
Published: July 2019

The aim of the study is a theoretical justification and development of a mechanism for the implementation of quality management systems (QMS) in the activities of retail trade in pharmaceutical products.Materials and methods. The study is based on the analysis of scientific literature data and Analytical Normative Documents regulating various aspects of QMS functioning in pharmaceutical organizations. Methods of documentary content analysis of international and national ISO standards, Series 9000, were used as the basis for the development and implementation of QMS organizations despite the type of their activities.Results. In the course of the study, the organization of the production process has been studied and the main production (business-) operations of seven structural subdivisions of “Apteka-Alex” LLC in Angarsk have been analyzed. The basic principles of QMS functioning are set forth and the author’s methodology for its development for retail trade in pharmaceutical products has been presented, taking into account the specifics of the organizational structure and production activities of pharmacy organizations. The mechanisms and successive stages of the QMS implementation have been specified and given grounds for. In accordance with the requirements of GOST R ISO 9000:2015, the definitions and classification of the main production operations (business processes) of the studied pharmacies have been made up. In addition, the list of mandatory (core) and basic standard operating procedures (SOPs), detailing the main production (business-) processes, has been made up, and an algorithm for developing and testing SOPs has been outlined.Conclusion. The results of the study allowed us to justify and propose a step-by-step methods of QMS implementation into the work of pharmaceutical organizations in the retail sector. The first results of the approbation and use of the developed methodology show that it contributes to the rational construction and functioning of the QMS, in accordance with the requirements of the existing standards, as well as the optimization of administrative management of all production (business-) processes.
Coreia Aguda Generalizada, Distonia e Calcificações Cerebrais: A Propósito de um Caso Clínico
Authors: Ramos-Lopes Joana , Brás Ana , Morgadinho Ana , Moreira Fradique 
Published: July 2019

A calcificação dos núcleos da base, ou síndrome de Fahr, pode ser secundária a variadas doenças, nomeadamente as que cursam com envolvimento da paratiróide. Distúrbios do movimento são achados clínicos comuns, mas a coreia é observada em menos de 20% dos casos e a distonia apenas em 8%. Apresentamos o caso de um homem de 49 anos com antecedentes de tiroidectomia, admitido no serviço de urgência com coreia aguda generalizada e distonia focal dolorosa dos pés, cujo estudo laboratorial revelava hipocalcémia e rabdomiólise e a tomografia computorizada crânio-encefálica mostrava calcificações parenquimatosas extensas com envolvimento dos núcleos da base. A alargada investigação complementar permitiu fazer o diagnóstico de síndrome de Fahr secundária a hipoparatiroidismo iatrogénico. Após estabilização da calcémia, a evolução clínica foi favorável com resolução dos sintomasneurológicos. A hipocalcémia deve ser investigada e corrigida depois de tiroidectomias, dada a irreversibilidade das calcificações intracerebrais e as potenciais consequências neurológicas e sistémicas.
Uso dos Registos Clínicos Eletrónicos para Investigação: Novos Desafios Éticos e Soluções Possíveis
Authors: Meneses-Oliveira Carlos 
Published: July 2019

Alguns investigadores entendem que as Comissões de Ética para a Saúde são um bloqueio aos estudos clínicos observacionais. No que toca aos estudos retrospetivos há quem proponha resolver este problema tratando os Dados Pessoais de Saúde como dados administrativos simples na posse do Estado e há quem interprete o novo Regulamento Geral de Proteção de Dados (União Europeia) 2016/679 de forma menos garantista que a Lei nº 21/2014, de 16 de abril (sobre a Investigação Clínica), resultando em ambos os casos na presunção que o silêncio do participante constitui consentimento, mesmo se ninguém tentar sequer informá-lo do novo usodos seus dados. Estas soluções colidem com garantias éticas de proteção dos direitos dos doentes. Propomos uma alternativa ética a estas propostas.
Penentuan Kadar Logam B3 Dalam Pupuk Cair Dengan Metode Analisis Aktivasi Neutron (AAN)
Authors: Mulwandari Meike , Supriadi Harry , Fajarwati Febi Indah 
Published: July 2019

Telah dilakukan penentuan kadar logam B3 dalam sampel pupuk cair dengan Metode Analisis Aktivasi Neutron (AAN). Metode ini dilakukan dengan proses penembakan sinar gamma pada selongsong-selongsong yang sudah dipersiapkan. Selongsong yang terdiri dari sampel, standar dan blanko dimasukkan dalam Reaktor Kartini untuk diiradiasi dengan menggunakan sumber neutron (fluks neutron 5,85 . 1010 n cm-2 s-1) pada fasilitasi radiasi Lazy Susan selama 2 x 6 jam dengan daya 100 kW. Setelah itu dilakukan pendinginan sesuai dengan waktu paruh suatu unsur. Kemudian dilakukan pencacahan dengan menggunakan detektor HPGe pada umur menengah dan umur panjang. Berdasarkan hasil analisis secara kualitatif pada umur menengah mengandung unsur-unsur logam B3 seperti Sm, Ce, La, U, Th, Cd, K, As, Br dan Na untuk standar sedangkan unsur-unsur logam B3 yang terkandung didalam sampel 1, sampel 2 dan blanko yaitu Sm, Ce, La, Th, As, Br, K dan Na. Berdasarkan hasil analisis kualitatif pada umur panjang terdapat unsur-unsur logam B3 seperti Cr, Cs, Fe, Zn dan Co pada standar. Pada sampel 1 terdapat unsur-unsur logam Cr, Fe, Zn dan Co. Pada sampel 2 terdapat unsur-unsur logam Fe, Zn dan Co sedangkan pada blanko hanya terdapat unsur logam Cr. Hasil analisis kuantitatif pada umur menengah diperoleh unsur yang paling banyak yaitu unsur K dengan kadar sebesar 44121,6370 ± 948,966 dan presisi 2,1508%. Sedangkan unsur yang paling sedikit yaitu unsur Sm diperoleh nilai kadar sebesar 0,0190 ± 0,003 dan presisi 14,3074%. Adapun hasil analisis kuantitatif pada umur panjang diperoleh unsur yang paling banyak yaitu unsur Zn dengan kadar sebesar 267,1754 ± 7,384 dan presisi 2,7638%. Sedangkan unsur yang paling sedikit yaitu unsur Cr diperoleh nilai kadar sebesar 0,2250 ± 0,270 dan presisi 0,1215%.
Meningkatkan Kreativitas Anak Melalui Kegiatan Bermain Warna (Penelitian Tindakan Kelas pada Anak Kelompok B di RA Muslimat NU 107 Khodijah Kramat Duduksampeyan)
Authors: Adhani Dwi Nurhayati , Hanifah Nina , Hasanah Imro’atun 
Published: July 2019

Children not need social emotional, language, motoric, moral development but alsoneed creativity development. Creativity is ability to produce something new. This study aims to determine creativity development between playing (with coconut pulp). . This research is done by collecting data from various ways that is observation, interview, documentation. The result of this study can be conclude that in RA Muslimat NU 107 Duduk Sampeyan improvement when using playing with coconut pulp. From the results of this study, it can be appealed to early childhood educators to apply byplaying coconut pulp to improve the creativity of children.
Meningkatkan Kemampuan Berkomunikasi Anak Melalui Metode Cerita Bergambar pada PAUD Kelompok B
Authors: Syukur Abdul , Tefanai Meo Melianus 
Published: July 2019

The aim of this research is to improve the communication skills of children through the method of pictorial stories applied to group B ECD Gemilang in the District of Maulafa, Kota Kupang. This is a type of Classroom Action Research that consists of four stages in each cycle, they are: planning, implementation, observation and reflection. The main focus of this research is to improve children's skills and ability to communicate through this pictorial story method. Nineteen children have been included in this study and the data has been collected through observation and tests. The results show that the average score of pre-cycle is 37.57%, the one of the first cycle is 57.89% and 100% is the average score achieved in the second cycle. Looking at these results, it can be stated that using pictorial stories in a learning process can improve children’s communication skills and ability.
Peningkatan Kreatifitas Melalui Funcooking pada Kelompok A RA Az Zahra Kebayoran Baru Jakarta Selatan
Authors: Lestari Dwi Puji 
Published: July 2019

<p class="Default">The purpose of this research is how to increase creativity through fun cooking in group A RA Az Zahra Kebayoran Baru South Jakarta. This study was carried out in 4-5 years old group A children of 16 children. This research is an action research with Kemmis and Taggart model which consists of 4 stages namely (plan, action, observation and reflection). This study consisted of 2 cycles, with each cycle as many as 8 meetings. Data collection techniques are using observation, field notes, and documentation. Data analysis uses quantitative and qualitative. Quantitative data analysis is carried out with statistical descriptions to compare pre cycles to cycles II. The stages of qualitative analysis are data reduction, data display and verification. The results showed that there was an increase in creativity through the method of fun cooking. The results of the study in cycle I, and cycle II, the results of which increased significantly from before the action only 37.5% of the number of children in the class increased to 81% in cycle 2. The average value of the percentage in the pre-action was 33.20%; cycle 1 is 59.76% and cycle 2 is 84.375%. The increase from cycle 1 to cycle 2 reached 24.615%.<strong></strong></p><pre> </pre>
A single-center retrospective observational cohort study on postoperative pain management: better with single or continuous doses of opiates or acetaminophen?
Authors: Tennichi Takashi , Taniguchi Takumi 
Published: July 2019

Abstract
Background: Proper pain management after cardiac surgery is essential for the prevention of postoperative complications, and several protocols have been proposed in this regard. The continuous administration of an opioid is a common approach now because it allows for more prolonged post-surgical analgesic effects. However, this method has several problems, such as the incidence of protracted delirium, nausea, and vomiting. The present study aims to evaluate the effects of two opioid administration methods on postoperative pain management and other clinical outcomes after cardiac surgery.
Methods: This is a retrospective observational cohort study that enrolled 184 adult patients who underwent elective cardiac surgery. After ICU admission, patients were divided into two groups: 101 patients who received a single administration of fentanyl (25 mg boluses and a 30 min lockout time) and an administration of acetaminophen (l5 mg kg-1 and a 6 hour lockout time) [group S] and 83 patients who underwent continuous administration of fentanyl (25 mg hour-1 with 35 mg boluses and a 30 min lockout time) and an administration of acetaminophen (l5 mg kg-1 and a 6 hour lockout time) [group C]. For all patients, the Intensive Care Delirium Screening Checklist (ICDSC) scores were measured soon after extubation (0 hours) and 12, 24, and 36 hours later. Similarly, for all patients, NRS scores were also quickly measured after extubation (0 hours) and 8, 16, and 24 hours later.
Results: ICDSC scores in group S were significantly lower than those in group C 0 and 12 hours after extubation (p < 0.001). However, ICDSC scores 24 and 36 hours post extubation did not differ significantly between the two groups. NRS scores did not differ significantly between the two groups until 24 hours after extubation.
Conclusions: Compared with single administration of fentanyl with acute administration of acetaminophen, continuous administration of postoperative fentanyl with acute administration of acetaminophen may lead to increased risk for postoperative delirium. Therefore, acute administration of fentanyl may be preferable for continuous use in postoperative cardiac surgery patients.
MAGINITUDE AND ASSOCIATED FACTORS OF DEPRESSION AMONG HYPERTENSIVE PATIENTS ATTENDING TREATMENT FOLLOW UP IN CHRONIC OPD AT HAWASSA UNIVERSITY COMPREHENSIVE SPECIALIZED HOSPITAL, HAWASSA, SOUTHERN ETHIOPIA
Authors: Gebre Bereket Beyene , Deribe Bedilu , Abeto Mintesnot 
Published: July 2019

Abstract
ABSTRACT
Objective: The aim of this study was to assess the magnitude and factors associated with depression among Hypertensive patients attending treatment follow up in chronic OPD at Hawassa University comprehensive Specialized Hospital (HUCSH) from March to May, 2019.
Result: The magnitudes of depression among Hypertension (HPN) patients were found to be 73 (24.7%). The independent predictors were Sex 2.6(1.16, 5.83), Age 11.2(2.98, 42), educational status, Social support 2.55 (1.09, 5.94), family history of depression 7.12(1.48, 34.26), hypertension 7.57(2.67, 21.44) and medication adherence 11.6(4.23, 31.78). So, continuous health information dissemination at different level regard to factors affecting them should be given. Strengthen a referral linkage with psychiatric unit for psycho behavioral therapy will bring good clinical outcome. Besides, controlling hypertension was crucial to bring good clinical outcome.
Key words: depression, magnitude, associate factor, patient health questionnaire (PHQ-9).
FACTORS ASSOCIATED WITH ALCOHOL USE DISORDER AMONG PEOPLE LIVING WITH HIV/AIDS ATTENDING ART CLINIC, MIZAN TEP UNIVERISTY TEACHING HOSPITAL, SOUTH WEST ETHIOPIA
Authors: Gebre Bereket Beyene 
Published: July 2019

Abstract
Abstract
Objective: To assess the magnitude of alcohol use and factors among HIV/AIDS positive adults visiting ART clinic at Mizan Tep university Teaching Hospital (MTUTH), Southern Ethiopia from October 2017 to December 2017.
Result: A total of 332 participants were enrolled in the study with the prevalence of alcohol use disorder (AUD) of 18.4%. Factors associated with alcohol use disorder were sex AOR=3.48 (95%CI: 1.27, 9.59), cigarette smoking AOR=5.12(95%CI:4.02,8.61), “Khat” chewing AOR=3.23(95%CI: 2.06,6.89),and CD4 count of 0-200 AOR = 19.49 (95% CI:1.74 ,218.4).
Key words:-Magnitude, Alcohol use disorder, factors.
Screening differentially expressed genes of pancreatic cancer between Mongolian and Han people using bioinformatics technology
Authors: Xu Jiasheng , Liao Kaili , FU ZHONGHUA , XIONG ZHENFANG 
Published: July 2019

Abstract
Objective

To screen and analyze differentially expressed genes in pancreatic carcinoma tissues taken from Mongolian and Han patients by Affymetrix Genechip. Methods: Pancreatic ductal cell carcinoma tissues were collected from the Mongolian and Han patients undergoing resection in the Second Affiliated Hospital of Nanchang University during March 2015 to May 2018 and the total RNA was extracted. Differentially expressed genes were selected from the total RNA qualified by Nanodrop 2000 and Agilent 2100 using Affymetrix and a cartogram was drawn; The gene ontology (GO) analysis and Pathway analysis were used for the collection and analysis of biological information of these differentially expressed genes. Finally, some differentially expressed genes were verified by real-time PCR.

Results

Through the microarray analysis of gene expression, 970 differentially expressed genes were detected by comparing pancreatic cancer tissue samples between Mongolian and Han patients. A total of 257 genes were significantly up-regulated in pancreatic cancer tissue samples in Mongolian patients;while a total of 713 genes were down-regulated. In the Gene Ontology database, 815 differentially expressed genes were identified with clear GO classification, and CPB1 gene had the highest multiple of differential expression (difference multiple: 31.76). The Pathway analysis detected 28 signaling pathways that included these differentially expressed genes, involving a total of 178 genes. Among these pathways, the enrichment of differentially expressed genes in the FAK signaling pathway was the highest and COL11A1 gene had the highest multiple difference (multiple difference: 5.02). The expressions of differentially expressed genes CPB1, COL11A1、ITGA4、BIRC3、PAK4、CPA1、CLPS、PIK3CG and HLA-DPA1 determined by real-time PCR were consistent with the results of gene chip analysis.

Conclusions

The results of microarray analysis of gene expression profiles showed that there are a large number of differentially expressed genes in pancreatic cancer tissue samples compared between Mongolian and Han populations. These genes are closely related to the proliferation, differentiation, invasion and metastasis and multi-drug resistance of pancreatic cancer and are involved in the regulation of multiple important signaling pathways in organisms.
Immunohistochemical expression of Cyclin D1 among Sudanese patients diagnosed with benign and malignant prostatic lesions
Authors: Ahmed Eiman Siddig , Elnour Lubna S. , Hassan Rowa , Siddig Emmanuel Edwar , Chacko Mintu Elsa , Ali Eman Taha , Mohamed Mona A. , Munir Abdalla , Muneer Mohamed S. , Mohamed Nouh Saad , Edris Ali Mahmoud Mohammed 
Published: July 2019

Abstract
Objectives: Prostate cancer (PC) is common cancer worldwide. Several markers have been developed to differentiate between benign prostatic hyperplasia (BPH) from PC. A descriptive retrospective hospital-based study aimed at determining the expression of Cyclin D1 in BPH and PC. the study took place at different histopathology laboratories in Khartoum state, Sudan, from December 2016 to January 2019. Formalin-fixed paraffin-embedded blocks were sectioned and fixed in 3-aminopropyltriethoxysilane coated slides incubated into primary antibody for Cyclin D1. The assessment of immunoreactivity of Cyclin D1 of each section was done using the Gleason scoring system.
Results: A total of 153 males’ prostate sections included in this study, of them, 120 (78.4%) were PC, and 33 (21.6%) were BPH. Their age ranged from 45 to 88 years, mean age was 66.19 ± 8.599. 142 (92.8%) did not have a family history of PC, while 11 (7.2%) patients reported having a family history. The Gleason scoring showed a total of 81 (52.9%) patients with high-grade and 39 (25.5%) with low-grade. 118 (97.5%) patients had PC showed positive results for Cyclin D1, while BPH was 3 (2.5%). P value < 0.001. Cyclin D1 staining was associated with high-grade Gleason score and perineural invasion, P value 0.001.
PERBANDINGAN RERATA KADAR HbA1c PADA PASIEN DIABETES MELITUS DENGAN NEUROPATI DAN TANPA NEUROPATI SENSORI MOTOR
Authors: Tanhardjo Jerry , Pinzon Rizaldy Taslim , Sari Lisa Kurnia 
Published: July 2019

Latar Belakang: Neuropati diabetika/polineuropati diabetika ditandai munculnya kehilangan fungsi saraf secara progresif. Komplikasi ini terjadi pada 50% pasien dengan DM tipe 1 dan 2. Kadar HbA1c dapat menggambarkan rata-rata kadar glukosa dalam darah selama 2-3 bulan terakhir. Pemeriksaan ini penting pengelolaan pasien DM dalam jangka panjang dan pasien DM dengan perubahan gula darah yang dramatis setiap harinya. Penelitian sebelumnya mengenai HbA1c dan neuropati masih belum jelas.
Tujuan: Penelitian ini bertujuan untuk membandingkan rerata kadar HbA1c pada pasien DM dengan neuropati dan tanpa neuropati sensori motor.
Metodologi: Penelitian ini adalah penelitian potong lintang. Penelitian dilakukan di RS Bethesda, Yogyakarta. Pengambilan sampel dengan metode consecutive sampling, dengan jumlah sampel sebanyak 64 sampel. Semua sampel dilakukan screening neuropati sensori motor menggunakan Diabetic Neuropathy Examination, Diabetic Neuropathy Symptom, dan Monofilament Test. Sampel terbagi menjadi 2 kelompok : DM Neuropati (DMN) dan DM Tidak Neuropati (DMTN); masing-masing kelompok terdiri dari 32 sampel.
Hasil: Hasil penelitian pada 64 sampel menunjukkan bahwa kelompok DMN memiliki rerata kadar HbA1c (% ; mean ± SD) lebih tinggi dibandingkan kelompok DMTN (9,61 ± 2,60 Vs. 9,05 ± 2,35). Hasil analisis data menggunakan uji Chi-Square menunjukkan tidak terdapat hubungan bermakna antara rerata kadar HbA1c terhadap neuropati (p = 0,368). Pada penelitian ini didapatkan durasi DM menunjukkan hubungan bermakna terhadap neuropati (p = 0,006).
Kesimpulan: Rerata kadar HbA1c ditemukan lebih tinggi pada pasien DM dengan neuropati sensori motor dibandingkan pada pasien DM tidak neuropati sensori motor, namun secara statistik tidak signifikan.
How much data is required for a robust and reliable wastewater characterization?
Authors: Yang Cheng , Barrott Wendy , Busch Andrea , Mehrotra Anna , Madden Jane , Daigger Glen T. 
Published: July 2019

Abstract
Water resource recovery facility (WRRF) modeling requires robust and reliable characterization of the wastewater to be treated. Poor characterization can lead to unreliable model predictions, which can have significant economic consequences when models are used to make important facility upgrade/expansion and operational decisions. Current wastewater characterization practice often involves a limited number of relatively short-duration intensive campaigns. On-going work at the Great Lakes Water Authority (GLWA) WRRF, serving 3.1 million residents in Southeast Michigan, provided an opportunity to conduct more detailed wastewater characterization over an annual cycle. The collection system includes a significant combined sewer component, and the WRRF provides primary and secondary treatment (high purity oxygen activated sludge) and phosphorus removal via ferric chloride addition. Detailed wastewater fractionation was conducted weekly over a one-year period. Daily conventional secondary influent and process operational data from that same period were used to evaluate the efficiency of various wastewater characterization strategies on the bioreactor mixed liquor volatile suspended solids (MLVSS) concentration calculated using an International Water Association (IWA) Activated Sludge Model Number 1 (ASM1) with minor modifications. An adaptive strategy consisting of a series of short-duration characterization campaigns, used to assess model fit for its intended purpose and continued until a robust and reliable model result, is recommended. Periods of unusual plant influent and/or operational conditions should be identified, and data from these periods potentially excluded from the analysis. Sufficient data should also be collected to identify periods when poor model structure, rather than wastewater characterization, leads to poor fit of the model to actual data.
A Review on Adenocarpus mannii; a Main Species of the Genus Adenocarpus
Authors: Nganou Blaise K. , Selvaraj Jubie , Tane Pierre , Nchiozem Alex , Simo Ingrid , MVNL Chaitanya , Palanisamy Dhanabal 
Published: July 2019

:
The fabaceae are rooted in rosaceae pods known as "vegetables" by the early botanists.
They are the third family of angiosperms which includes 642 genus divided into about
18,000 species. The fabaceae family is known as the most important family of the ecosystem
as it is indispensable in medicine, agriculture, industry and livestock. The Adenocarpus genus
has about 50 species that are frequently found in tropical regions of Northern Africa, the
southern part of West Europe and in the central and southern Italy. They are used in traditional
medicine for the treatment of several diseases: such as microbial infections, leprosy,
scabies, acne, malaria and other plants species are used in agriculture as insecticidal properties.
Mainly Adenocarpus mannii species is well represented in the tropical regions of North
Africa. It occurs in Angola, Mozambique, Malawi, Guinea, South Africa, Tanzania, and Burundi.
In Cameroon, it is encountered in South West Region and West Region. Previous phytochemical
studies led to the isolation of several classes of compounds such as flavonoids,
alkaloids and triterpenes. Several studies report the phytochemical studies on genus Adenocarpus
and chemotaxonomic markers of species of this genus. Herein, we outline all the botanical,
pharmacological and phytochemical aspects of Adenocarpus mannii. A brief introduction
about fabaceae and the genus Adenocarpus has also been included.