bluuebunny/crossref_metadata_2025_split huggingface dataset:
IN VIVO OBSERVATION OF RETINAL VASCULAR DEPOSITS USING ADAPTIVE OPTICS IMAGING IN FABRY DISEASE
Authors: Sodi Andrea , Germain Dominique P. , Bacherini Daniela , Finocchio Lucia , Pacini Bianca , Marziali Elisa , Lenzetti Chiara , Tanini Ilaria , Koraichi Fairouz , Coriat Caroline , Nencini Patrizia , Olivotto Iacopo , Virgili Gianni , Rizzo Stanislao , Paques Michel 
Published: September 2019

Purpose:
To report a novel finding in patients with Fabry disease, that is, the observation by adaptive optics ophthalmoscopy of intracellular lipidic deposits in retinal vessels.

Methods:
Observational two-center case series. Eighteen patients with genetically proven Fabry disease underwent flood-illumination adaptive optics ophthalmoscopy imaging (rtx1; Imagine Eyes, Orsay, France) of retinal vessels.

Results:
Fourteen patients (78% of all patients; 7 of the 10 women and 7 of the 8 men) showed paravascular punctuate or linear opacities in both eyes. In the least-affected patients, these were seen only in the wall of precapillary arterioles as discrete spots of 5 µm to 10 µm large, whereas in those more severely affected, capillaries and first-order vessels were also involved with diffuse opacification of the wall. These deposits sometime showed a striated pattern, suggesting colocalization with vascular smooth muscle cells.

Conclusion:
Adaptive optics ophthalmoscopy of retinal vessels may be of interest for patients with Fabry disease, providing noninvasive, gradable evaluation of microvascular involvement.
Historical approaches for hospitality and tourism research
Authors: MacKenzie Niall G. , Pittaki Zoi , Wong Nicholas 
Published: September 2019

Purpose
This paper aims to show how historical approaches can better inform understanding of hospitality and tourism research. Recent work in business and management has posited the value of historical research and narrative frameworks to explicate business phenomena – here the authors propose an approach to hospitality and tourism studies could be similarly beneficial.

Design/methodology/approach
Three principal historical approaches are proposed: systematic study of historical archives, oral histories and biography and prosopography. The paper further proposes that such work should be aligned to Andrews and Burke’s framework of the 5Cs: context, change over time, causality, complexity and contingency to help situate research appropriately and effectively.

Findings
This paper suggests that historical methods can prove particularly useful in hospitality and tourism research by testing, extending and creating theory that is empirically informed and socially situated. The analysis put forward shows that undertaking historical work set against the framework of the 5Cs of historical research offers the potential for wider and deeper understandings of hospitality and tourism research by revealing temporal and historical dynamics in the field that may hitherto be unseen or insufficiently explored.

Originality/value
Much of the existing work on the benefits of historical approaches in business and management has focussed on the why or the what. This paper focuses on the how, articulating how historical approaches offer significant potential to aid the understanding of hospitality and tourism research.
Exploring health and wellbeing in prison: a peer research approach
Authors: Perrett Stephanie E. , Gray Benjamin J. , G. L. , E. D. , Brooks Neville J. 
Published: September 2019

Purpose
Those in prison have expert knowledge of issues affecting their health and wellbeing. The purpose of this paper is to report on work undertaken with male prisoners. This paper presents learning and findings from the process of engaging imprisoned men as peer researchers.

Design/methodology/approach
The peer researcher approach offers an emic perspective to understand the experience of being in prison. The authors established the peer research role as an educational initiative at a long-stay prison in Wales, UK to determine the feasibility of engaging imprisoned men as peer researchers. Focus groups, interviews and questionnaires were used by the peer researchers to identify the health and wellbeing concerns of men in prison.

Findings
The project positively demonstrated the feasibility of engaging imprisoned men as peer researchers. Four recurring themes affecting health and wellbeing for men in a prison vulnerable persons unit were identified: communication, safety, respect and emotional needs. Themes were inextricably linked demonstrating the complex relationships between prison and health.

Originality/value
This was the first prison peer-research project to take place in Wales, UK. It demonstrates the value men in prison can play in developing the evidence base around health and wellbeing in prison, contributing to changes within the prison to improve health and wellbeing for all.
Relative advantage of interactive electronic banking adoption by premium customers
Authors: Chan Chun Kwong , Fang Yulin , Li Huifang 
Published: September 2019

Purpose
The purpose of this paper is to develop a nuanced understanding of premium customers’ intent to adopt an interactive electronic channel (IEC) and the moderating role of social capital on perceived relative advantage (RA) in adoption.

Design/methodology/approach
Study findings are based on a field survey that investigates the launching of an IEC by a leading international bank in Hong Kong.

Findings
Among social capital dimensions, cognitive capital significantly weakens the relationship between efficacy of information acquisition and IEC adoption, while relational capital enhances the relationship between trust and adoption.

Research limitations/implications
This paper provides a theoretical lens based on social capital theory for evaluating the moderating effects of social capital on the relationship between RA and IEC adoption by premium customers in the banking industry.

Practical implications
Findings provide insights for the practice of banks when trying to deliver financial services via an IEC to the premium customer segment.

Originality/value
This research extends the channel choice theory to the context of banking channel adoption of premium customers; provides a better understanding of the IEC and its adoption in the more complex setting of financial consultation services; and offers insights for a better understanding of fragmented findings on the relationships between adoption intention and its antecedents in response to calls for studies on contingent factors.
Strategic capabilities for managing risks in supply chains: current state and research futurities
Authors: C.R. Vishnu , Sridharan R. , Gunasekaran Angappa , Ram Kumar P.N. 
Published: September 2019

PurposeThe purpose of this paper is to investigate the distinction and relationships between the significant strategic capabilities for managing risks in supply chains. This intersectional review exposes a substantial conceptual contradiction between the perspectives reported by various researchers. Further, the current paper classifies the literature into four categories according to the broad objectives investigated by the research papers.Design/methodology/approachInitially, a bibliometric analysis aligned with the concepts of a systematic literature review is conducted followed by a descriptive review focusing on models and methods. The software called BibExcel is utilized to extract and analyze the bibliographic information in a textual form from the research articles associated with strategic capabilities of the logistics sector. The results are exported to the software known as Gephi to visualize keyword co-occurrence analysis as networks. A well-structured descriptive review is also conducted to identify avenues for future research.FindingsDespite conventional supply chain capabilities like efficiency and effectiveness, eight significant strategic capabilities of supply chains for managing risks are identified from the literature. These capabilities with positive connotations include flexibility, reliability, resilience, robustness, agility, adaptability, alignment and responsiveness. Considering the vast literature on flexibility/reliability along with its numerous dimensions and scope, the authors found that resilience, robustness, agility, adaptability, alignment and effectiveness are achievable through flexibility/reliability. Accordingly, it is appropriate to state reliability and flexibility as supply chain capabilities to achieve the other six supply chain competencies. Furthermore, the entire literature in this domain can be classified into four genres according to the addressed objectives, namely, concept development/validation, capability assessment, network design and performance evaluation.Research limitations/implicationsThe information revealed from the keyword co-occurrence analysis along with the research implications provided in the penultimate section will assist budding researchers in framing novel and promising research objectives. Supply chain administrators and policymakers can utilize the literature classification and the notable references provided in this review for locating potential methods for assessing supply chain strategic capabilities, designing the supply chain and evaluating the performance of the supply chain.Originality/valueAn integrated bibliometric and descriptive literature review procedure is utilized in this paper. Furthermore, this critical review is the first work on comprehensively mapping the research relationships among various strategic capabilities required for mitigating supply chain risks.
The Humanitarian Supply Chain Assessment Tool (HumSCAT)
Authors: Banomyong Ruth , Julagasigorn Puthipong , Varadejsatitwong Paitoon , Piboonrungroj Pairach 
Published: September 2019

Purpose
An understanding of the “AS-IS” stage of a relief operation is the basis for further action in humanitarian supply chain management. The purpose of this paper is to develop a toolbox called the Humanitarian Supply Chain Assessment Tool (HumSCAT). This toolbox is comprised of a set of basic tools which can be classified into each phase of disaster relief.

Design/methodology/approach
The HumSCAT is proposed by paralleling frequently used tools in commercial supply chains with the objectives and characteristics of relief phases. A case study was used to validate the HumSCAT along with six tools provided in the preparation phase.

Findings
The HumSCAT consists of seven tools in the preparation phase, nine tools in the response phase and ten tools in the recovery phase. The case study illustrates how to use the HumSCAT and the six tools. The latter were found to be useful for improving the relief chain.

Research limitations/implications
The list of tools is not exclusive. Other tools might be applicable as long as they meet the objectives and characteristics of the phase. A tool should be adjusted accordingly to the contexts. Tools in other phases should be validated in future research.

Practical implications
The HumSCAT may serve as a reference toolbox for practitioners. Its output can be used for further designing of the “TO-BE” status of humanitarian relief chains.

Originality/value
The HumSCAT is proposed as a toolbox for academics and practitioners involved in humanitarian supply chains.
Dual solutions of a micropolar nanofluid flow with radiative heat mass transfer over stretching/shrinking sheet using spectral quasilinearization method
Authors: Magodora Mangwiro , Mondal Hiranmoy , Sibanda Precious 
Published: September 2019

Purpose
The purpose of this paper is to focus on the application of Chebyshev spectral collocation methodology with Gauss Lobatto grid points to micropolar fluid over a stretching or shrinking surface. Radiation, thermophoresis and nanoparticle Brownian motion are considered. The results have attainable scientific and technological applications in systems involving stretchable materials.

Design/methodology/approach
The model equations governing the flow are transformed into non-linear ordinary differential equations which are then reworked into linear form using the Newton-based quasilinearization method (SQLM). Spectral collocation is then used to solve the resulting linearised system of equations.

Findings
The validity of the model is established using error analysis. The velocity, temperature, micro-rotation, skin friction and couple stress parameters are conferred diagrammatically and analysed in detail.

Originality/value
The study obtains numerical explanations for rapidly convergent solutions using the spectral quasilinearization method. Convergence of the numerical solutions was monitored using the residual error analysis. The influence of radiation, heat and mass parameters on the flow are depicted graphically and analysed. The study is an extension on the work by Zheng et al. (2012) and therefore the novelty is that the authors tend to take into account nanoparticles, Brownian motion and thermophoresis in the flow of a micropolar fluid.
Modification of the cyclopropyl moiety of abacavir provides insight into the structure activity relationship between HLA‐B*57:01 binding and T‐cell activation
Authors: Thomson Paul J. , Illing Patricia T. , Farrell John , Alhaidari Mohammad , Bell Catherine C. , Berry Neil , O’Neill Paul M. , Purcell Anthony W. , Park Kevin B. , Naisbitt Dean J. 
Published: September 2019

AbstractBackgroundAbacavir is associated with hypersensitivity reactions in individuals positive for the HLA‐B*57:01 allele. The drug binds within the peptide binding groove of HLA‐B*57:01 altering peptides displayed on the cell surface. Presentation of these HLA‐abacavir‐peptide complexes to T‐cells is hypothesized to trigger a CD8+ T‐cell response underpinning the hypersensitivity. Thus, the aim of this study was to explore the relationship between the structure of abacavir with HLA‐B*57:01 binding and the CD8+ T‐cell activation.MethodsSeventeen abacavir analogues were synthesized and cytokine secretion from abacavir/abacavir analogue‐responsive CD8+ T‐cell clones was measured using IFN‐γ ELIspot. In silico docking studies were undertaken to assess the predicted binding poses of the abacavir analogues within the HLA‐B*57:01 peptide binding groove. In parallel, the effect of selected abacavir analogues on the repertoire of self‐peptides presented by cellular HLA‐B*57:01 was characterized using mass spectrometry.ResultsAbacavir and ten analogues stimulated CD8+ T‐cell IFN‐γ release. Molecular docking of analogues that retained antiviral activity demonstrated a relationship between predicted HLA‐B*57:01 binding orientations and the ability to induce a T‐cell response. Analogues that stimulated T‐cells displayed a perturbation of the natural peptides displayed by HLA‐B*57:01. The antigen‐specific CD8+ T‐cell response was dependent on the enantiomeric form of abacavir at both cyclopropyl and cyclopentyl regions.ConclusionAlteration of the chemical constitution of abacavir generates analogues that retain a degree of pharmacological activity, but have variable ability to activate T‐cells. Modelling and immunopeptidome analysis delineate how drug HLA‐B*57:01 binding and peptide display by antigen presenting cells relate to the activation of CD8+ T‐cells.
NanoSr – A New Carbonate Microanalytical Reference Material for In Situ Strontium Isotope Analysis
Authors: Weber Michael , Lugli Federico , Hattendorf Bodo , Scholz Denis , Mertz‐Kraus Regina , Guinoiseau Damien , Jochum Klaus Peter 
Published: September 2019

The in situ measurement of Sr isotopes in carbonates by MC‐ICP‐MS is limited by the availability of suitable microanalytical reference materials (RMs), which match the samples of interest. Whereas several well‐characterised carbonate reference materials for Sr mass fractions > 1000 µg g−1 are available, there is a lack of well‐characterised carbonate microanalytical RMs with lower Sr mass fractions. Here, we present a new synthetic carbonate nanopowder RM with a Sr mass fraction of ca. 500 µg g−1 suitable for microanalytical Sr isotope research (‘NanoSr’). NanoSr was analysed by both solution‐based and in situ techniques. Element mass fractions were determined using EPMA (Ca mass fraction), as well as laser ablation and solution ICP‐MS in different laboratories. The 87Sr/86Sr ratio was determined by well‐established bulk methods for Sr isotope measurements and is 0.70756 ± 0.00003 (2s). The Sr isotope microhomogeneity of the material was determined by LA‐MC‐ICP‐MS, which resulted in 87Sr/86Sr ratios of 0.70753 ± 0.00007 (2s) and 0.70757 ± 0.00006 (2s), respectively, in agreement with the solution data within uncertainties. Thus, this new reference material is well suited to monitor and correct microanalytical Sr isotope measurements of low‐Sr, low‐REE carbonate samples. NanoSr is available from the corresponding author.
Spinal glycinergic and gamma‐aminobutyric acid‐ergic neurons inhibit the micturition reflex after electrical stimulation of the perineum in rats with pelvic venous congestion
Authors: Sugaya Kimio , Nishijima Saori , Kadekawa Katsumi , Noguchi Katsuhiko , Ueda Tomoyuki , Yamamoto Hideyuki 
Published: September 2019

ObjectivesTo examine whether electrical stimulation of the perineum inhibited urinary frequency in rats with pelvic venous congestion, and whether electrical stimulation influences spinal glycinergic/gamma‐aminobutyric acid‐ergic neurons.MethodsBilateral common iliac veins and bilateral uterine veins were ligated to create pelvic venous congestion rats. At 4 weeks after ligation, cystometry was carried out before and after electrical stimulation with/without intrathecal injection of strychnine (a glycine receptor antagonist) and/or bicuculline (a gamma‐aminobutyric acid type A receptor antagonist). In addition, measurement of amino acid levels in the lumbosacral cord was carried out with/without electrical stimulation, and cystometry was carried out after oral administration of glycine.ResultsContinuous cystometry showed that the interval between bladder contractions was shorter in pelvic venous congestion rats than in sham rats. Electrical stimulation did not change cystometric parameters in sham rats, but the interval between bladder contractions was increased by electrical stimulation in pelvic venous congestion rats. Electrical stimulation increased the levels of glutamic acid, glycine, gamma‐aminobutyric acid, and taurine in the lumbosacral cord of pelvic venous congestion rats. Intrathecal strychnine abolished the effects of electrical stimulation in pelvic venous congestion rats, and intrathecal administration of both strychnine and bicuculline shortened the interval between bladder contractions more than before electrical stimulation. Oral administration of glycine (3%) to pelvic venous congestion rats increased bladder capacity.ConclusionsElectrical stimulation of the perineum inhibits urinary frequency mainly through activation of spinal glycinergic neurons, and partly through activation of gamma‐aminobutyric acid‐ergic neurons in a rat model of pelvic venous congestion.
Ureteric stents: Overview of current clinical applications and economic implications
Authors: Sali Gaurav Mohan , Joshi Hrishikesh B 
Published: September 2019

AbstractUreteric stents are one of the most crucial tools used for various clinical conditions in the urological field. Placement of a ureteric stent, for short‐ or long‐term use, remains one of the commonest urological interventional procedures. In the past few decades, ureteral stents have undergone notable technological advancements. However, an ideal stent without significant side‐effects is yet to be engineered. Indwelling ureteric stents are often accompanied by physical distress to the patient and clinical complications, such as bacterial adhesion, encrustation, malpositioning, stent fracture and forgotten stent syndrome, that influence patients’ health‐related quality of life. In the market, different stent types are available, designed to reduce infections, and improve patient symptoms and tolerance. In this review, we have emphasized the recent developments that have taken place in stent design, size, materials and coating. This overview looks at current practices and problems related to stents, along with clinical and economic considerations. Few trial studies have been enumerated in the context of utilization of a ureteral stent symptom questionnaire and various stent models to compare their effects in patients.
Musical anhedonia and rewards of music listening: current advances and a proposed model
Authors: Belfi Amy M. , Loui Psyche 
Published: September 2019

AbstractMusic frequently elicits intense emotional responses, a phenomenon that has been scrutinized from multiple disciplines that span the sciences and arts. While most people enjoy music and find it rewarding, there is substantial individual variability in the experience and degree of music‐induced reward. Here, we review current work on the neural substrates of hedonic responses to music. In particular, we focus the present review on specific musical anhedonia, a selective lack of pleasure from music. Based on evidence from neuroimaging, neuropsychology, and brain stimulation studies, we derive a neuroanatomical model of the experience of pleasure during music listening. Our model posits that hedonic responses to music are the result of connectivity between structures involved in auditory perception as a predictive process, and those involved in the brain's dopaminergic reward system. We conclude with open questions and implications of this model for future research on why humans appreciate music.
A genome‐wide CRISPR screen identifies FBXO42 involvement in resistance toward MEK inhibition in NRAS‐mutant melanoma
Authors: Nagler Adi , Vredevoogd David W. , Alon Michal , Cheng Phil F. , Trabish Sophie , Kalaora Shelly , Arafeh Rand , Goldin Victoria , Levesque Mitchell P. , Peeper Daniel S. , Samuels Yardena 
Published: September 2019

AbstractNRAS mutations are the most common alterations among RAS isoforms in cutaneous melanoma, with patients harboring these aggressive tumors having a poor prognosis and low survival rate. The main line of treatment for these patients is MAPK pathway‐targeted therapies, such as MEK inhibitors, but, unfortunately, the response to these inhibitors is variable due to tumor resistance. Identifying genetic modifiers involved in resistance toward MEK‐targeted therapy may assist in the development of new therapeutic strategies, enhancing treatment response and patient survival. Our whole‐genome CRISPR‐Cas9 knockout screen identified the target Kelch domain‐containing F‐Box protein 42 (FBXO42) as a factor involved in NRAS‐mutant melanoma‐acquired resistance to the MEK1/2 inhibitor trametinib. We further show that FBXO42, an E3 ubiquitin ligase, is involved in the TAK1 signaling pathway, possibly prompting an increase in active P38. In addition, we demonstrate that combining trametinib with the TAK1 inhibitor, takinib, is a far more efficient treatment than trametinib alone in NRAS‐mutant melanoma cells. Our findings thus show a new pathway involved in NRAS‐mutant melanoma resistance and provide new opportunities for novel therapeutic options.