bluuebunny/crossref_metadata_2025_split huggingface dataset:
Relationship between rosacea and dietary factors: A multicenter retrospective case–control survey
Authors: Yuan Xin , Huang Xin , Wang Ben , Huang Yin‐xue , Zhang Yi‐ya , Tang Yan , Yang Jin‐yan , Chen Qi , Jian Dan , Xie Hong‐fu , Shi Wei , Li Ji 
Published: January 2019

AbstractAlthough patients with rosacea often consult dermatologists for dietary factors that might be related to their skin disorders, few studies have been conducted to research the relationship between rosacea and dietary factors. The purpose of this study was to evaluate the potential relationship between rosacea and diet among the large Chinese population with rosacea, which would provide dietary guidelines for patients with rosacea. A multicenter case–control study was conducted. The feeding frequency 2 years before the occurrence of rosacea was collected by standardized questionnaires. Multiple logistic regression analysis was used to calculate risks related to the diet. One thousand three hundred and forty‐seven patients with rosacea and 1290 controls were enrolled in our study. We found that high‐frequency intake of fatty food and tea presented a positive correlation with rosacea, while high‐frequency dairy product intake showed significant negative correlation with rosacea. Sweet food, coffee and spicy food appeared to be independent of any subset of rosacea in our study. However, high‐frequency dairy product intake showed a borderline beneficial effect on rosacea severity. We further analyzed the correlation between diet and the subtype of rosacea. We found that high‐frequency fatty intake was associated with erythematotelangiectatic rosacea (ETR) and phymatous rosacea, while high‐frequency tea intake was only associated with ETR. In addition, high‐frequency dairy product intake showed negative correlations with ETR and papulopustular rosacea. Rosacea is associated with some dietary factors, and our study is valuable in establishing dietary guidelines to prevent and improve rosacea.
Changes in the soil meso‐ and micro‐fauna community under the impacts of exotic Ambrosia artemisiifolia
Authors: Qin Zhong , Xie Jun F. , Quan Guo M. , Zhang Jia E. , Mao Dan J. , Wang Jia X. 
Published: January 2019

AbstractSuccessful establishment of invasive plant species may exert important effects on soil organisms and processes. To investigate the response of the soil meso‐ and micro‐fauna community to Ambrosia artemisiifolia L. invasion and its age of colonization, samples were collected from three different depths in sites with and without the presence of A. artemisiifolia during the period of October, 2009 to July, 2010. Soil fauna were grouped into four categories, that is, Nematoda, Acarina, Collembola and other meso‐ and micro‐fauna species. Seasonal changes in abundance and distribution patterns in relation to soil biochemical properties were then compared and examined. In general, invasion of A. artemisiifolia into native plants significantly increased the soil fauna densities, especially nematodes. Effects of invasion on soil fauna groups were seasonally variable with density peaking in autumn. Short‐term invasion of A. artemisiifolia could weaken accumulation of soil fauna groups in the top layer. Vertical distribution of soil meso‐ and micro‐fauna communities changed seasonally with the trend of remarkable upward migrations in the period from winter, summer to spring and autumn, though the degrees of upward migration in the invaded and noninvaded sites differed among the fauna groups. Responses of soil fauna communities may be associated with the enhancement of soil nutrient conditions and microbial activities in the presence of A. artemisiifolia. That is, the colonization of A. artemisiifolia, irrespective of colonization age, may exert an important influence on soil meso‐ and micro‐fauna community over time and thus may be beneficial to its successful colonization.
The effect of administration mode onCAHPSsurvey response rates and results: A comparison of mail and web‐based approaches
Authors: Fowler Floyd J. , Cosenza Carol , Cripps Lauren A. , Edgman‐Levitan Susan , Cleary Paul D. 
Published: January 2019

ObjectiveThe objective of this study was to compare response rates, respondents' characteristics, and substantive results forCAHPSsurveys administered using web and mail protocols.Data SourcesPatients who had one or more primary care visits in the preceding 6 months.Study Design/Data Collection MethodsPatients for whom primary care practices had email addresses were randomized to one of four survey administration protocols: web via a portal invitation; web via an email invitation; combination of web and mail; and mail only. Another sample of patients without known email addresses was surveyed by mail. Samples of nonrespondents to the Internet and mail protocols were surveyed by telephone.Principal FindingsResponse rates to surveys administered using the Internet protocols were lower than for the surveys administered by mail (20 percent vs over 40 percent). However, characteristics of respondents and survey answers were very similar across protocols. Respondents without email addresses were older, less educated, and more likely to be male than those with email addresses, and there were a few differences in their responses. There was little evidence of nonresponse bias in either the mail or web protocols.ConclusionIn this well‐educated patient population, web protocols had lower response rates, but substantive results very similar to those from mail protocols.
A 1‐year perspective on goal‐directed therapy in elderly with hip fracture: Secondary outcomes
Authors: Bartha Erzsebet , Davidson Thomas , Berg Hans E. , Kalman Sigridur 
Published: January 2019

BackgroundWe have previously reported inconclusive results from a randomized controlled trial in elderly with hip‐fracture comparing intra‐operative goal‐directed therapy with routine fluid treatment. Now we aimed to describe and compare secondary outcomes at 4 months and 1 year follow‐up and to analyze the cost‐effectiveness.MethodsPatients with hip fracture (age ≥70) were randomized for GDT or routine fluid treatment (RFT). The secondary outcomes were long‐term survival, complications, number of hospital readmissions, and quality of life (EQ‐5D) changes. Additionally, cost effectiveness was analyzed by an analytic tool which combines the clinical effectiveness, quality of life changes and costs.ResultsPatient data (GDT n = 74; RFT n = 75) were analyzed on an intention to treat basis. Statistically significant differences (GDT vs RFT) were not found considering survival (RR 0.76, 95%CI 0.45‐1.28) and complications (RR 0.68, 95% CI 0.4‐1.10) at 12 months. No statistically significant difference was found between hospital readmissions and quality of life changes.ConclusionThe statistical uncertainty of risk reduction of negative outcomes and the large variability of the collected data indicate the need of further research in large sample sizes. To enable future health economic evaluation for decision support surrounding implementation of GDT, we suggest adding patient‐oriented outcomes in future trials.
No association between Helicobacter pylori infection and gastrointestinal complaints in a large cohort of symptomatic children
Authors: Chobot Agata , Porębska Jolanta , Krzywicka Agnieszka , Żabka Alicja , Bąk‐Drabik Katarzyna , Pieniążek Wojciech , Dubik Andrzej , Adamczyk Piotr , Kwiecień Jarosław 
Published: January 2019

AbstractAimThis Polish study estimated the prevalence of the Helicobacter pylori infection in symptomatic children aged 3–18 and investigated its association with gastrointestinal complaints.MethodsWe prospectively enrolled 1984 children (54% female) with a mean age of 9.5 ± 4.1 years, from Silesia, Poland, for the Good Diagnosis Treatment Life screening programme from 2009 to 2016. They underwent a 13C‐isotope‐labelled urea breath test (UBT) to assess their Helicobacter pylori status, making this the biggest Polish study to use this approach. Further analysis included parental‐reported gastrointestinal symptoms and standard deviation scores (SDS) of anthropometric measurements.ResultsThe Helicobacter pylori infection was identified in 220 (11%) children (48% female) and was independent of age and sex. The frequency of symptoms did not differ between Helicobacter positive and negative children (all p > 0.05). Children with a positive UBT result had a lower body mass SDS (−0.41 ± 0.98 versus −0.26 ± 1.01, p = 0.04) and height SDS (−0.45 ± 1.34 versus −0.23 ± 1.27, p = 0.02), but similar body mass index SDS.ConclusionWe found a low prevalence of Helicobacter pylori in symptomatic children, and positive UBT results were not associated with symptoms that suggested Helicobacter pylori infections. Our findings support the 2017 European and North American guidelines for Helicobacter infections in children.
Impaired butyrate absorption in the proximal colon, low serum butyrate and diminished central effects of butyrate on blood pressure in spontaneously hypertensive rats
Authors: Yang Tao , Magee Kacy L. , Colon‐Perez Luis M. , Larkin Riley , Liao Yan‐Shin , Balazic Eliza , Cowart Jonathan R. , Arocha Rebeca , Redler Ty , Febo Marcelo , Vickroy Thomas , Martyniuk Christopher J. , Reznikov Leah R. , Zubcevic Jasenka 
Published: January 2019

AbstractAimButyrate is a major gut microbiota‐derived metabolite. Reduced butyrate‐producing bacteria has been reported in the spontaneously hypertensive rat (SHR), a model of hypertension characterized by dysfunctional autonomic nervous system and gut dysbiosis. Here, we demonstrate a potential mechanism for butyrate in blood pressure regulation.MethodsHigh‐performance liquid chromatography and liquid chromatography‐mass spectrometry were performed to measure butyrate levels in feces and serum. Ussing chamber determined butyrate transport in colon ex vivo. Real‐time PCR and immunohistochemistry evaluated expression of butyrate transporter, Slc5a8, in the colon. Mean arterial blood pressure was measured in catheterized anesthetized rats before and after a single butyrate intracerebroventricular injection. Activity of cardioregulatory brain regions was determined by functional magnetic resonance imaging to derive neural effects of butyrate.ResultsIn the SHR, we demonstrated elevated butyrate levels in cecal content, but diminished butyrate levels in circulation, possibly due to reduced expression of Slc5a8 transporter in the colon. In addition, we observed lower expression levels of butyrate‐sensing receptors in the hypothalamus of SHR, likely leading to the reduced effects of centrally administered butyrate on blood pressure in the SHR. Functional magnetic resonance imaging revealed reduced activation of cardioregulatory brain regions following central administration of butyrate in the SHR compared to control.ConclusionWe demonstrated a reduced availability of serum butyrate in the SHR, possibly due to diminished colonic absorption. Reduced expression of butyrate‐sensing receptors in the SHR hypothalamus may explain the reduced central responsiveness to butyrate, indicating microbial butyrate may play a role in blood pressure regulation.
Re‐examining the reciprocal effects model of self‐concept, self‐efficacy, and academic achievement in a comparison of the Cross‐Lagged Panel and Random‐Intercept Cross‐Lagged Panel frameworks
Authors: Burns Richard A. , Crisp Dimity A. , Burns Robert B. 
Published: January 2019

BackgroundThe cross‐lagged panel (regression) model (CLPM) is the usual framework of choice to test the longitudinal reciprocal effects between self‐concept and achievement. Criticisms of the CLPM are that causal paths are over‐estimated as they fail to discriminate between‐ and within‐person variation. The random‐intercept cross‐lagged panel model (RI‐CLPM) is one alternative that extends the CLPM by partialling out between‐person variance.AimsWe compare analyses from a CLPM and a RI‐CLPM which examine the reciprocal relationships between self‐concept, self‐efficacy, and achievement and determine the extent CLPM estimates are inflated by between‐person variance.Sample(s)Participants (n = 314) were first‐year undergraduate psychology students recruited as part of the STudent Engagement with Education and Learning (STEEL) project.MethodsParticipants completed measures of self‐efficacy and self‐concept prior to completing fortnightly quiz assessments.ResultsCross‐Lagged Panel (regression) Model estimates are likely over‐estimated in comparison with RI‐CLPM estimates. Cross‐Lagged Panel (regression) Model analyses identified a reciprocal effects relationship between self‐concept and achievement, confirming established literature. In RI‐CLPM analyses, these effects were attenuated and a skill development association between achievement and self‐concept was supported. A reciprocal relationship between self‐efficacy and achievement was supported. Better model fit was reported for the RI‐CLPM analyses.ConclusionsPrior findings relating to the reciprocal effects of self‐concept and achievement need to be reconsidered. Whilst such a relationship was supported in a CLPM analysis in this study, within an RI‐CLPM framework, only achievement predicted self‐concept. However, in both CLPM and RI‐CLPM models a reciprocal effects model of self‐efficacy and achievement was supported.
Altered expression of metabolic pathways in CLL detected by unlabelled quantitative mass spectrometry analysis
Authors: Thurgood Lauren A. , Dwyer Eveline S. , Lower Karen M. , Chataway Tim K. , Kuss Bryone J. 
Published: January 2019

SummaryChronic lymphocytic leukaemia (CLL) remains the most common incurable malignancy of B cells in the western world. Patient outcomes are heterogeneous and can be difficult to predict with current prognostic markers. Here, we used a quantitative label‐free proteomic technique to ascertain differences in the B‐cell proteome from healthy donors and CLL patients with either mutated (M‐CLL) or unmutated (UM‐CLL) IGHV to identify new prognostic markers. In peripheral B‐CLL cells, 349 (22%) proteins were differentially expressed between normal B cells and B‐CLL cells and 189 (12%) were differentially expressed between M‐CLL and UM‐CLL. We also examined the proteome of proliferating CLL cells in the lymph nodes, and identified 76 (~8%) differentially expressed proteins between healthy and CLL lymph nodes. B‐CLL cells show over‐expression of proteins involved in lipid and cholesterol metabolism. A comprehensive lipidomic analysis highlighted large differences in glycolipids and sphingolipids. A shift was observed from the pro‐apoptotic lipid ceramide towards the anti‐apoptotic/chemoresistant lipid, glucosylceramide, which was more evident in patients with aggressive disease (UM‐CLL). This study details a novel quantitative proteomic technique applied for the first time to primary patient samples in CLL and highlights that primary CLL lymphocytes display markers of a metabolic shift towards lipid synthesis and breakdown.
Signalling by hydrogen sulfide and polysulfides via protein S‐sulfuration
Authors: Kimura Hideo 
Published: January 2019

Hydrogen sulfide (H2S) is a signalling molecule that regulates neuronal transmission, vascular tone, cytoprotection, inflammatory responses, angiogenesis, and oxygen sensing. Some of these functions have recently been ascribed to its oxidized form polysulfides (H2Sn), which can be produced by 3‐mercaptopyruvate sulfurtransferase (MPST), also known as a H2S‐producing enzyme. H2Sn activate ion channels, tumour suppressors, transcription factors, and protein kinases. H2Sn S‐sulfurate (S‐sulfhydrate) cysteine residues of these target proteins to modify their activity by inducing conformational changes through the formation of a disulfide bridge between the two cysteine residues involved. The chemical interaction between H2S and NO also generates H2Sn, which may be a chemical entity that exerts the synergistic effect of H2S and NO. MPST also produces redox regulators cysteine persulfide (CysSSH), GSH persulfide (GSSH), and persulfurated proteins. In addition to MPST, haemoproteins such as haemoglobin, myoglobin, neuroglobin, and catalase as well as SOD can produce H2Sn, and sulfide quinone oxidoreductase and cysteinyl tRNA synthetase can make GSSH and CysSSH. This review focuses on the recent progress in the study of the production and physiological roles of these persulfurated and polysulfurated molecules.Linked ArticlesThis article is part of a themed section on Hydrogen Sulfide in Biology & Medicine. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v177.4/issuetoc
REV7 confers radioresistance of esophagus squamous cell carcinoma by recruiting PRDX2
Authors: Gu Cheng , Luo Judong , Lu Xujing , Tang Yiting , Ma Yan , Yun Yifei , Cao Jianping , Cao Juhua , Huang Zeyu , Zhou Xifa , Zhang Shuyu 
Published: January 2019

Radiotherapy has been widely used for the clinical management of esophageal squamous cell carcinoma. However, radioresistance remains a serious concern that prevents the efficacy of esophageal squamous cell carcinoma (ESCC) radiotherapy. REV7, the structural subunit of eukaryotic DNA polymerase ζ, has multiple functions in bypassing DNA damage and modulating mitotic arrest in human cell lines. However, the expression and molecular function of REV7 in ESCC progression remains unclear. In this study, we first examined the expression of REV7 in clinical ESCC samples, and we found higher expression of REV7 in ESCC tissues compared to matched adjacent or normal tissues. Knockdown of REV7 resulted in decreased colony formation and increased apoptosis in irradiated Eca‐109 and TE‐1 cells coupled with decreased tumor weight in a xenograft nude mouse model postirradiation. Conversely, overexpression of REV7 resulted in radioresistance in vitro and in vivo. Moreover, silencing of REV7 induced increased reactive oxygen species levels postirradiation. Proteomic analysis of REV7‐interacting proteins revealed that REV7 interacted with peroxiredoxin 2 (PRDX2), a well‐known antioxidant protein. Existence of REV7‐PRDX2 complex and its augmentation postirradiation were further validated by immunoprecipitation and immunofluorescence assays. REV7 knockdown significantly disrupted the presence of nuclear PRDX2 postirradiation, which resulted in oxidative stress. REV7‐PRDX2 complex also assembled onto DNA double‐strand breaks, whereas REV7 knockdown evidently increased double‐strand breaks that were unmerged by PRDX2. Taken together, the present study sheds light on REV7‐modulated radiosensitivity through interacting with PRDX2, which provides a novel target for ESCC radiotherapy.
Longitudinal analysis to better characterize Asthma‐COPD overlap syndrome: Findings from an adult asthma cohort in Korea (COREA)
Authors: Park So‐Young , Jung Heewon , Kim Jung‐Hyun , Seo Bomi , Kwon Oh Young , Choi Sungkyoung , Oh Bermseok , Kwon Hyouk‐Soo , Cho You Sook , Moon Hee‐Bom , Won Sungho , Park Taesung , Kim Tae‐Bum 
Published: January 2019

SummaryBackgroundAsthma‐chronic obstructive pulmonary disease (COPD) overlap syndrome (ACOS), which has received much attention, has not been unanimously defined.ObjectiveIn this study, we tried to demonstrate that longitudinally defined ACOS is more useful in the real world than blending patients with asthma and COPD.MethodsThe study patients had undergone two consecutive pulmonary function tests measured at least 3 months apart (n = 1889). We selected the patients who had positive bronchodilator response or methacholine provocation tests (n = 959). Next, we defined ACOS as a patient with a persistent airflow obstruction [forced expiratory volume in 1 second (FEV1)/forced vital capacity <0.7] that was identified twice consecutively by an interval of at least 3 months (n = 228).ResultsThe proportions of patients who were older, male and smokers were significantly higher, and baseline lung function was lower in patients with ACOS. In the longitudinal analysis, the mean change in lung function was high, and a greater decline in FEV1 was observed in patients with ACOS. In addition, we compared ACOS and severe asthma, and we also performed a cluster analysis and compared the results with our definition of ACOS. According to our definition, ACOS is an independent subtype with distinctive characteristics. Finally, a genome‐wide association study (GWAS) was performed to identify genetic variations associated with ACOS, but no significant single nucleotide polymorphisms were identified.ConclusionOur findings suggest that ACOS should be defined longitudinally and considered as an independent subgroup distinguished by inherited environmental factors rather than as a genetically distinct independent group.
Insulin resistance is associated with hirsutism in unselected reproductive‐aged women
Authors: Song Do Kyeong , Lee Hyejin , Hong Young Sun , Sung Yeon‐Ah 
Published: January 2019

SummaryObjectiveHirsutism affects 5%‐10% of reproductive‐aged women worldwide and exhibits clinical importance as a cutaneous manifestation of underlying hyperandrogenism. Racial and genetic factors play roles in manifestation of hirsutism, and the prevalence of hirsutism seems to be low in East Asians. However, the reference value of the modified Ferriman‐Gallwey (mFG) score to diagnose hirsutism and the prevalence of hirsutism have not been determined in Korean populations to date. We aimed to investigate the distribution of the mFG score and establish its reference value for defining hirsutism and to examine its relationship with metabolic and reproductive traits in reproductive‐aged Korean women.Design, patients and measurementsWe enrolled 2139 female volunteers of reproductive age (15‐39 years). We recorded mFG scores from 0 to 4 on 9 different body locations (upper lip, chin, chest, arm, upper abdomen, lower abdomen, upper back, lower back and thighs). Hirsutism was defined as >95th percentile of mFG score. In addition, a 75‐g oral glucose tolerance test was performed, and the homoeostasis model assessment of insulin resistance (HOMA‐IR) was calculated.ResultsThe mFG values of the 50th, 75th, 90th and 95th percentiles were 0, 1, 4 and 6, respectively. Therefore, the mFG score was indicative of hirsutism when the score was 6 or greater, which represents the 95th percentile. In the correlation analysis, total testosterone, free testosterone, fasting plasma insulin and HOMA‐IR were positively correlated with mFG score (all Ps <0.05). Multiple linear regression analysis revealed that HOMA‐IR (β = 0.081) was positively associated with mFG score after adjustments for age, body mass index, total testosterone and the number of menses per year (P < 0.001).ConclusionsIn conclusion, setting the 95th percentile of the mFG score as normal, the reference value to define hirsutism was 6 in reproductive‐aged Korean women. HOMA‐IR was positively associated with the mFG score even after adjustment for biochemical hyperandrogenism.