bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Geodiversidade como atratividade turística nos Parques Nacionais brasileiros e Parques Estaduais dos Estados do Paraná e Pernambuco / Geodiversity as a touristic attraction at the Brazilian National Parks (...)
Authors: Manosso Fernando César , Moreira Jasmine Cardozo , Silva Junior Edvaldo Dias da 
Published: June 2018

A natureza constitui uma estrutura complexa de elementos físicos, químicos e biológicos que, combinados entre si, podem formar paisagens com elevado valor cênico, sobretudo em Unidades de Conservação. Tais paisagens atraem turistas que realizam diferentes atividades, ao buscar o conhecimento, o contato, a interação ou a interpretação da natureza. Considerando que os atrativos turísticos podem possuir um conteúdo principal que motiva a visitação, esse trabalho tem como objetivo analisar os atrativos existentes nos Parques Nacionais brasileiros e Parques Estaduais dos Estados do Paraná e Pernambuco e quantificar os atrativos a partir de uma classificação entre conteúdos associados a geodiversidade, a biodiversidade e aos aspectos históricos e culturais. Foram utilizados dados do Guia Philips de Parques Nacionais (2003) e os atrativos foram separados nas categorias citadas anteriormente. A metodologia englobou também visitas a algumas das UCs, levantamentos bibliográficos sobre turismo em áreas naturais, geodiversidade e geoturismo. Conclui-se que o principal conteúdo do atrativo ou o elemento principal da paisagem envolvida nas unidades de conservação avaliadas é destacado, em todas as regiões, pela geodiversidade como atração principal, seja por um motivo cênico, científico ou exótico. Palavras-Chave: Geodiversidade, geoturismo, atratividade turística e parques nacionais. AbstractNature is a complex structure of physical, chemical and biological aspects, which combined can form landscapes with high scenic value, especially in protected areas. Such landscapes attract tourists engaged in different activities, to seek knowledge, contact, interaction or interpretation of nature. Considering that the tourist attractions can have a key content that motivates the visitation, this study aims to analyze the existing attractions in the National Parks and State Parks of the Brazilian states of Paraná (South Region) and Pernambuco (Northeast Region) and quantify the atractive a classification of content associated with geodiversity, biodiversity and historical and cultural aspects. Data were utilized from the Philips National Parks Guide (2003), and the attractions were separated in the categories listed above. The methodology also encompassed visits to some of the Protected Areas, bibliographic surveys on tourism in natural areas, geodiversity and geotourism. It is concluded that geodiversity is the most common group of elements presented in the analyzed protected areas, with the exception of the State Parks of Pernambuco. Keywords: Geodiversity, Geotourism, touristic attraction and National Parks.
Políticas de fomento à leitura e ações para a participação da pessoa com deficiência visual em Uberaba-MG
Authors: Pereira Dulceana , Carvalho Luciana Beatriz de Oliveira Bar 
Published: June 2018

Este artigo se trata de uma pesquisa documental e bibliográfica, cuja proposta foi avaliar o impacto das políticas de fomento à leitura, o Programa Nacional de Incentivo à Leitura (PROLER) e a inclusão de alunos com deficiência visual nas unidades de ensino do município de Uberaba-MG a partir da busca e identificação de projetos relacionados ao PROLER em Projetos Políticos Pedagógicos (PPP) de dez escolas municipais de Uberaba e conhecer como se dá a participação das pessoas com deficiência visual nessas ações de incentivo à leitura. Entende-se que a compreensão da Inclusão precisa ser abordada como política pública, devendo nortear a construção e a compreensão histórica de seus avanços e entraves. Autores como Jambeiro, Borges e Barros (2006), Libâneo (2001), Mantoan (2006) e Vasconcellos (2000) foram utilizados como referencial teórico deste artigo. Como resultados, foram encontradas ações isoladas, ora sobre a inclusão por meio das tecnologias para o deficiente visual, ora sobre práticas de leitura por meio de experiências exitosas em pontos isolados. Os PPPs pesquisados mostraram ações de leitura sem a participação direta das ações do comitê Vale do Rio Grande, sediado por Uberaba. Ressalta-se a necessidade de maiores estudos para que a população, os gestores e demais órgãos públicos possam respeitar as diferenças e compreender as reais necessidades da pessoa com deficiência, garantindo assim sua autonomia nos diversos espaços da sociedade. Palavras-chave: Deficiência Visual. PROLER. Projeto Político Pedagógico.
Læreres kompetenceudvikling - ud fra knowledge-of-practice
Authors: Møller Hanne , Skott Charlotte Krog 
Published: June 2018

Resume
For at kunne skelne mellem tiltag til lærerudvikling har Cochran-Smith og Lytle udviklet tre grundforståelser af forholdet mellem læreres viden og deres praksis. En af disse, Knowledge-of-practice, er udgangspunkt for artiklen, idet vi med Lektionsstudier eksemplificerer potentialerne ved at benytte tiltag inden for denne grundforståelse. I Japan benyttes lektionsstudier i alle fag, mens tiltaget i Vesten overvejende bruges i matematikfaget og med et fagdidaktisk fokus. Ud fra en case om lektionsstudier i danskfaget argumenterer vi for, at tiltag som lektionsstudier giver lærere mulighed for at udforske og løse problemstillinger i deres undervisningspraksis fra et samtidigt alment og fagdidaktisk perspektiv.

Abstract
To be able to differentiate between approaches to teachers’ professional development, Cochran-Smith and Lytle have developed three conceptions of the relationships between teachers’ knowledge and their practice. One of these, Knowledge-of-practice, is the basis for this article, as we use Lesson studies to exemplify the potentials of approaches within this conceptualization. In Japan, Lesson studies are used in all subjects, whereas in the West the approach predominantly is used in Mathematics and with a focus on pedagogical content knowledge. Based on a lesson study case in the subject of Danish, we argue that approaches as lesson study provide teachers the possibility to research and solve teaching problems with a focus simultaneously on pedagogical knowledge and pedagogical content knowledge.
Searching clinical trial registries in interventional physical therapy systematic reviews: A Pilot Cross-sectional Analysis
Authors: Abou Khzam Alaa 
Published: June 2018

Background. Studies with positive findings are more likely to be published compared to those with negative findings. Therefore the latter studies are often disregarded in systematic reviews. This causes an overestimation of a treatment effect size which leads to a misinterpretation of the evidence. Searching clinical trial registries in systematic reviews is a useful source to retrieve unpublished clinical trials leading to the reduction of publication bias. Previous studies in the literature reported inconsistent searching of clinical trial registries in systematic reviews published in several medical fields. Searching clinical trial registries in physical therapy is still unknown. The aim of this cross-sectional analysis is to evaluate the extent of clinical trial registry searching in physical therapy interventional systematic reviews.
Methods. Systematic reviews published between January 2017 and January 2018 were retrieved from five reputable physical therapy journals. Interventional systematic reviews that were coherent with the inclusion criteria were included in the analysis.
Results. The search yielded 40 systematic reviews. Among these 19 were interventional systematic reviews as well as being consistent with the inclusion criteria and thus were considered for the analysis. After reviewing their search methodology, only two reviews (10.5%) reported searching at least one clinical trial registry.
Discussion. The results of this study suggest poor searching of clinical trial registries in physical therapy systematic reviews. Due to the limitations of this study, further research analyzing large samples of interventional physical therapy systematic reviews is required.
Flexible Artificial Synaptic Devices Based on Collagen from Fish Protein with Spike‐Timing‐Dependent Plasticity
Authors: Raeis‐Hosseini Niloufar , Park Youngjun , Lee Jang‐Sik 
Published: June 2018

AbstractNeuromorphic and cognitive computing with a capability of analyzing complicated information is explored as a new paradigm of intelligent systems. An implementation of a renewable material as an essential building block of an artificial synaptic device is suggested and a flexible and transparent synaptic device based on collagen extracted from fish skin is demonstrated. This device exhibits essential synaptic behaviors including analog memory characteristics, excitatory postsynaptic current, and paired‐pulse facilitation as short‐term plasticity. The brain‐inspired electronic synapse undergoes incremental potentiation and depression when flat or bent. The device emulates spike‐timing‐dependent plasticity when stimulated by engineered pre‐ and post‐neuron spikes with the appropriate time difference between the imposed pulses. The proposed synaptic device has the advantage of being biocompatible owing to use of Mg electrodes and collagen as a naturally abundant protein. This device has a potential to be used in flexible and implantable neuromorphic systems in the future.
Bioinspired Multifunctional Hybrid Hydrogel Promotes Wound Healing
Authors: Chen Guopu , Yu Yunru , Wu Xiuwen , Wang Gefei , Ren Jianan , Zhao Yuanjin 
Published: June 2018

AbstractInspired by the coordinated multiple healing mechanism of the organism, a four‐armed benzaldehyde‐terminated polyethylene glycol and dodecyl‐modified chitosan hybrid hydrogel with vascular endothelial growth factor (VEGF) encapsulation are presented for efficient and versatile wound healing. The hybrid hydrogel is formed through the reversible Schiff base and possesses self‐healing capability. As the dodecyl tails can insert themselves into and be anchored onto the lipid bilayer of the cell membrane, the hybrid hydrogel has outstanding tissue adhesion, blood cell coagulation and hemostasis, anti‐infection, and cell recruitment functions. Moreover, by loading in and controllably releasing VEGF from the hybrid hydrogel, the processes of cell proliferation and tissue remodeling in the wound bed can be significantly improved. Based on an in vivo study of the multifunctional hybrid hydrogel, it is demonstrated that acute tissue injuries such as vessel bleeding and liver bleeding can be repaired immediately because of the outstanding adhesion and hemostasis features of the hydrogel. Moreover, the chronic wound‐healing process of an infectious full‐thickness skin defect model can also be significantly enhanced by promoting angiogenesis, collagen deposition, macrophage polarization, and granulation tissue formation. Thus, this multifunctional hybrid hydrogel is potentially valuable for clinical applications.
Core–Satellite Mesoporous Silica–Gold Nanotheranostics for Biological Stimuli Triggered Multimodal Cancer Therapy
Authors: Jin Ronghua , Liu Zhongning , Bai Yongkang , Zhou Yongsheng , Gooding J. Justin , Chen Xin 
Published: June 2018

AbstractA core–satellite nanotheranostic agent with pH‐dependent photothermal properties, pH‐triggered drug release, and H2O2‐induced catalytic generation of radical medicine is fabricated to give a selective and effective tumor medicine with three modes of action. The nanocomplex (core–satellite mesoporous silica–gold nanocomposite) consists of amino‐group‐functionalized mesoporous silica nanoparticles (MSN‐NH2) linked to L‐cysteine‐derivatized gold nanoparticles (AuNPs‐Cys) with bridging ferrous iron (Fe2+) ions. The AuNPs‐Cys serve as both removable caps that control drug release (doxorubicin) and stimuli‐responsive agents for selective photothermal therapy. Drug release and photothermal therapy are initiated by the cleavage of Fe2+ coordination bonds at low pH and the spontaneous aggregation of the dissociated AuNPs‐Cys. In addition, the Fe2+ is able to catalyze the decomposition of hydrogen peroxide abundant in cancer cells by a Fenton‐like reaction to generate high‐concentration hydroxyl radicals (·OH), which then causes cell damage. This system requires two tumor microenvironment conditions (low pH and considerable amounts of H2O2) to trigger the three therapeutic actions. In vivo data from mouse models show that a tumor can be completely inhibited after two weeks of treatment with the combined chemo‐photothermal method; the data directly demonstrate the efficiency of the MSN–Fe–AuNPs for tumor therapy.
A Conductive Nanowire‐Mesh Biosensor for Ultrasensitive Detection of Serum C‐Reactive Protein in Melanoma
Authors: Lin Zuan‐Tao , Li Yaxi , Gu Jianhua , Wang Huie , Zhu Zhuan , Hong Xia , Zhang Zijing , Lu Qinqin , Qiu Jingyi , Wang Xifan , Bao Jiming , Wu Tianfu 
Published: June 2018

AbstractDetection of extracutaneous melanoma is still challenging and is of importance in improving survival rate. In this report, an ultrasensitive biosensor is constructed where a C‐reactive protein (CRP) aptamers based molecular recognition core and a conductive polypyrrole (PPy) nanowire mesh based signal amplifier are developed. The conductive PPy nanowire (less than 10 nm in diameter) mesh architecture is uniformly dispersed within polymeric matrix via template‐free in situ synthesis. Serum CRP levels are quantitatively analyzed through monitoring the conductance change caused by polymeric network shrinkage upon the aptamer‐CRP binding. The limit of detection (LOD) of the polymeric sensor for human CRP sample can reach 7.85 × 10−19m. This CRP‐specific biosensor and a commercial CRP enzyme‐linked immunosorbent assay (ELISA) kit are used to perform side‐by‐side measurement of serum CRP in melanoma patients. The results indicate that this conductive polymeric senor is highly sensitive and selective in accurately discriminating melanoma patients from healthy controls using serum CRP as a biomarker, which is further validated by a commercial human CRP ELISA kit. Collectively, this novel ultrasensitive nanowire‐based polymeric biosensor may hold promise in biomarker detection and diagnosis of cancer.
Rational Design of Catalytic Centers in Crystalline Frameworks
Authors: Tu Wenguang , Xu You , Yin Shengming , Xu Rong 
Published: June 2018

AbstractCrystalline frameworks including primarily metal organic frameworks (MOF) and covalent organic frameworks (COF) have received much attention in the field of heterogeneous catalysts recently. Beyond providing large surface area and spatial confinement, these crystalline frameworks can be designed to either directly act as or influence the catalytic sites at molecular level. This approach offers a unique advantage to gain deeper insights of structure–activity correlations in solid materials, leading to new guiding principles for rational design of advanced solid catalysts for potential important applications related to energy and fine chemical synthesis. In this review, recent key progress achieved in designing MOF‐ and COF‐based molecular solid catalysts and the mechanistic understanding of the catalytic centers and associated reaction pathways are summarized. The state‐of‐the‐art rational design of MOF‐ and COF‐based solid catalysts in this review is grouped into seven different areas: (i) metalated linkers, (ii) metalated moieties anchored on linkers, (iii) organic moieties anchored on linkers, (iv) encapsulated single sites in pores, and (v) metal‐mode‐based active sites in MOFs. Along with this, some attention is paid to theoretical studies about the reaction mechanisms. Finally, technical challenges and possible solutions in applying these catalysts for practical applications are also presented.
Natriierung von Aromaten und Heteroaromaten im kontinuierlichen Durchfluss
Authors: Weidmann Niels , Ketels Marthe , Knochel Paul 
Published: June 2018

AbstractDie erste Natriierung von (Hetero)Aromaten im kontinuierlichen Durchfluss unter Verwendung von NaDA (Natriumdiisopropylamid) in Me2EtN wird beschrieben. Das beschriebene Protokoll ermöglicht die Natriierung von funktionalisierten Arylen und Heteroarylen, die sich bei Reaktionen im Kolben zersetzen. Die resultierenden Natrium‐(Hetero)Aromaten reagieren umgehend mit verschiedenen Elektrophilen, z. B. Ketonen, Aldehyden, Isocyanaten, Alkylbromiden und Disulfiden zu den gewünschten funktionalisierten (Hetero)Aromaten in hohen Ausbeuten. Eine Skalierung ist ohne weitere Optimierung möglich.
Ortsspezifische Funktionalisierung von Affimeren für die DNA‐PAINT‐Mikroskopie
Authors: Schlichthaerle Thomas , Eklund Alexandra S. , Schueder Florian , Strauss Maximilian T. , Tiede Christian , Curd Alistair , Ries Jonas , Peckham Michelle , Tomlinson Darren C. , Jungmann Ralf 
Published: June 2018

AbstractSuperauflösende Mikroskopie ermöglicht Bildgebung weit unterhalb des klassischen Beugungslimits von Licht. Technisch gesehen erreichen aktuelle Methoden sogar eine räumliche Auflösung auf Einzelmolekülebene. Dieser beeindruckende Erfolg kann jedoch nicht einfach auf die Bildgebung von zellulären Komponenten übertragen werden, da Sonden, die zur Markierung von Molekülen verwendet werden, entweder durch deren Größe (Antikörper) oder wegen begrenzter Verfügbarkeit limitiert sind (Nanokörper, Aptamere, genetisch‐kodierende Marker). In dieser Arbeit kombinieren wir kürzlich entwickelte Affimer‐Reagenzien mit einer ortsspezifischen DNA‐Funktionalisierung, um eine Färbung mit anschließender Bildgebung durch DNA‐PAINT zu erreichen. Hierfür benutzen wir ein Aktin‐bindendes Affimer. Diese kleinen, mit DNA konjugierten Affinitätsmarker könnten eine zukünftige Lösung für superauflösende Bildgebung mit hoher Multiplexkapazität darstellen.
Preparation of Ag‐doped g‐C3N4 Nano Sheet Decorated Magnetic γ‐Fe2O3@SiO2 Core–Shell Hollow Spheres through a Novel Hydrothermal Procedure: Investigation of the Catalytic activity for A3, KA2 Coupling Reactions and [3 + 2] Cycloaddition
Authors: Sadjadi Samahe , Malmir Masoumeh , Heravi Majid M. 
Published: June 2018

Taking advantageous of both g‐C3N4 and magnetic core‐shell hollow spheres, for the first time a heterogeneous and magnetically separable hybrid system was prepared through a novel and simple hydrothermal procedure and used for immobilization of bio‐synthesized Ag(0) nanoparticles. The hybrid system was fully characterized by using SEM/EDS, FTIR, VSM, TEM, XRD, TGA, DTGA, ICP‐AES, BET and elemental mapping analysis. The catalytic utility of the obtained system, h‐Fe2O3@SiO2/g‐C3N4/Ag, for promoting ultrasonic‐assisted A3, KA2 coupling reactions and [3 + 2] cycloaddition has been confirmed. The results established that the catalyst could efficiently catalyze the reaction to afford the corresponding products in high yields in short reaction times. The reusability study confirmed that the catalyst could be recovered and reused for at least five reaction runs with only slight loss of the catalytic activity. The hot filtration test also proved low silver leaching, indicating the heterogeneous nature of the catalysis.
Live imaging flow bioreactor for the simulation of articular cartilage regeneration after treatment with bioactive hydrogel
Authors: Bar Assaf , Ruvinov Emil , Cohen Smadar 
Published: June 2018

AbstractOsteochondral defects (OCDs) are conditions affecting both cartilage and the underlying bone. Since cartilage is not spontaneously regenerated, our group has recently developed a strategy of injecting bioactive alginate hydrogel into the defect for promoting endogenous regeneration of cartilage via presentation of affinity‐bound transforming growth factor β1 (TGF‐β1). As in vivo model systems often provide only limited insights as for the mechanism behind regeneration processes, here we describe a novel flow bioreactor for the in vitro modeling of the OCD microenvironment, designed to promote cell recruitment from the simulated bone marrow compartment into the hydrogel, under physiological flow conditions. Computational fluid dynamics modeling confirmed that the bioreactor operates in a relevant slow‐flowing regime. Using a chemotaxis assay, it was shown that TGF‐β1 does not affect human mesenchymal stem cell (hMSC) chemotaxis in 2D culture. Accessible through live imaging, the bioreactor enabled monitoring and discrimination between erosion rates and profiles of different alginate hydrogel compositions, using green fluorescent protein‐expressing cells. Mathematical modeling of the erosion front progress kinetics predicted the erosion rate in the bioreactor up to 7 days postoperation. Using quantitative real‐time polymerase chain reaction of early chondrogenic markers, the onset of chondrogenic differentiation in hMSCs was detected after 7 days in the bioreactor. In conclusion, the designed bioreactor presents multiple attributes, making it an optimal device for mechanistical studies, serving as an investigational tool for the screening of other biomaterial‐based, tissue engineering strategies.
Metabolic engineering of Saccharomyces cerevisiae for production of fatty acid–derived hydrocarbons
Authors: Zhang Yiming , Nielsen Jens , Liu Zihe 
Published: June 2018

AbstractFatty acid–derived hydrocarbons attract increasing attention as biofuels due to their immiscibility with water, high‐energy content, low freezing point, and high compatibility with existing refineries and end‐user infrastructures. Yeast Saccharomyces cerevisiae has advantages for production of fatty acid–derived hydrocarbons as its native routes toward fatty acid synthesis involve only a few reactions that allow more efficient conversion of carbon substrates. Here we describe major biosynthetic pathways of fatty acid–derived hydrocarbons in yeast, and summarize key metabolic engineering strategies, including enhancing precursor supply, eliminating competing pathways, and expressing heterologous pathways. With recent advances in yeast production of fatty acid–derived hydrocarbons, our review identifies key research challenges and opportunities for future optimization, and concludes with perspectives and outlooks for further research directions.