bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical evaluation of the efficacy and safety of the use of vagilac to treat bacterial vaginosis in pregnancy
Authors: Novikova S. V. , Logutova L. S. , Ignatyeva M. A. 
Published: September 2018

Objective: evaluation of the efficacy and safety of the use of probiotic Vagilac® in the prevention and treatment of vaginal dysbiosis in pregnancy.Material and methods: 140 pregnant women admitted to the Obstetric Probationary Ward of Moscow Regional Research Institute of Obstetrics and Gynecology of the Ministry of Health of Moscow at 36–39 weeks of gestation were examined and treated. All patients underwent complex clinical and laboratory examination. The patients were divided into 2 groups: I – 60 pregnant women with the established diagnosis of «bacterial vaginosis» (BV) and II – 80 pregnant women, who received antibacterial therapy due to exacerbation of infectious extragenital diseases. Of 140 pregnant women, 100 (60 from Group I and 40 from Group II) received oral probiotic Vagilac® for 10–14 days before delivery: 60 women to treat bacterial vaginosis, and 40 to prevent vaginal dysbiosis against the background of systemic antibiotic therapy. The remaining 40 pregnant women from Group II did not receive the probiotic, for which reason the second group was divided into two subgroups (IIa and IIb).Results: the drug has proved itself as a probiotic that is capable to restore vaginal microflora after various disorders, maintain and keep a healthy balance of bacteria that normally live in the vagina, prevent any disorders associated with antibiotic therapy. During vaginal delivery, traumatic injuries of the birth canal tissues were more common in patients who did not receive Vagilac®. The newborns who were born by the mothers who received Vagilac®, had no manifestations of severe forms of infectious and inflammatory diseases.The conclusion. The conducted studies showed that the treatment of bacterial vaginosis in pregnant women with probiotic Vagilak® was effective, did not adversely affect the fetus/child; in the group with and without BV no candidiasis vulvaginitis was detected.
Effect of omeprazole on the hypotensive efficacy of amlodipine depending on the genetic characteristics of patients
Authors: Dorofeeva M. N. , Sizova Zh. M. , Shikh E. V. , Lapidus N. I. , Ryzhikova K. A. , Denisenko N. P. , Grishina E. A. , Sychev D. A. 
Published: September 2018

Features of anti-hypertensive therapy amlodipiny at patients with the arterial hypertonia (AH) with comorbid pathology – kislotozavisimy diseases (KZZ), accepting омепразол, depending on genetic features of the patient are studied and analysed. It is shown that a certain genetic polymorphism of an isoenzyme of P450 3A4 cytochrome can shift a metabolism of an omeprazol towards P450 3A4 cytochrome and promote more expressed oppression of activity of this enzyme. Depending on rate of a metabolism at the sick AG and KZZ receiving a combination of an amlodipin and an omeprazol various anti-hypertensive effect of an amlodipin can be observed. Reliable differences in dynamics of indicators of daily monitoring of the arterial blood pressure (ABP) at sick AG - slow metabolizator and sick AG – fast and intermediate metabolizator are received. Decrease of the activity of an isoenzyme of P450 3A4 cytochrome at patients - slow metabolizator leads to retardation of a metabolism of an amlodipin and, as a result, to rising of its concentration in a blood plasma that is clinically shown by more expressed anti-hypertensive effect.
Organization of pharmacological support of patients with rare diseases in moscow as exemplified by pulmonary arterial hypertension
Authors: Zhuravleva M. V. , Lebedeva A. Yu. 
Published: September 2018

Orphan diseases are life-threatening, chronic, progressive and leading to a reduction in life expectancy or disability conditions. Patients with rare diseases are one of the vulnerable population groups, which is caused by several factors, such as insufficient awareness of practitioners about such diseases, complicated and lengthy diagnosis, and imperfection of legal environment in the area of pharmacological support of orphan diseases, when only 24 orphan diseases (List-24) are determined, which are treated at the expense of the RF subjects.Imperfection of federal orphan diseases legislation is shown on the example of providing patients with PAH-specific therapy: only idiopathic form of pulmonary hypertension is included in the federal List-24, there is no well-established mechanism of pharmacological support for patients with chronic thromboembolic pulmonary hypertension (CTEPH) that is not included in the List-24. The article describes the successful experience in providing patients with orphan diseases, regardless of the inclusion of nosology in List-24 in Moscow, through the creation and implementation of the transparent medical and pharmacological support regulation for patients with orthopaedic diseases, which settled the timely process of provision of patients with the necessary therapy. As a result, patients with CTEPH also have access to existing pathogenetic treatment that can prolong life and improve the quality of life of such patients.
А new drug in the complex therapy of diabetes mellitus. Post-registration experience in patients with type 1 and type 2 diabetes mellitus
Authors: Vorob'yev S. V. , Petrovskaya E. U. , Kuz'menko N. A. , Khripun I. A. 
Published: September 2018

Diabetes mellitus (DM), due to its high incidence and prevalence, presents an urgent problem for the scientific community, which requires new ways of treating and preventing complications. Existing hypoglycemic treatment approaches do not always contribute to the achievement of glycaemic targets.Objective. Study of Subetta-based therapy for patients with DM 1 and DM 2 in real-life clinical practice.Materials and methods. The program involved 71 patients with DM 1 and 289 patients with DM 2, HbA1c ≥ 7.0%, who took Subetta in combination therapy of diabetes. The duration of the program was 12 weeks. The laboratory examination included the determination of the level of HbA1c, fasting plasma glucose.Results. The administration of Subetta in complex therapy of DM 1 and DM 2 led to a significant reduction in HbA1c from 9.2 ± 1.85 to 8.13 ± 1.29 mmol/L and from 8.62 ± 1.54 to 7.49 ± 1.1 mmol/L, respectively (p<0.0001), reduction of fasting blood glucose from 9.33 to 7.65 mmol/l and from 9.25 to 7.08 mmol/l, respectively (p<0.0001). The effectiveness of therapy is highly appreciated by patients and physicians. The use of Subetta was not accompanied by the development of hypoglycemia and other adverse effects.Conclusion. In real-life clinical practice, use of new locally developed antidiabetic drug Subetta demonstrated a significant decrease of HbA1c and fasting blood glucose, with no episodes of hypoglycemia in patients with DM 1 and DM 2.
Evaluation of the effect of taurine on the course of coronary artery disease associated with diabetes of the 2nd type, in patients undergoing coronary revascularization
Authors: Svarovskaya A. V. , Garganeeva A. A. 
Published: September 2018

The aimwas to study the effect of taurine in the complex therapy of patients with coronary artery disease associated with type 2 diabetes mellitus (DM2) who underwent coronary revascularization.Material and methods. Examined 53 patients with coronary artery disease associated with type 2 diabetes, after undergoing endovascular revascularization of the myocardium, which were distributed in 2 groups. The 1st group included 30 patients who received, in addition to basic therapy, taurine at a dose of 500 mg 2 times a day. In group 2 (n = 23) – patients who received only basic therapy of ischemic heart disease and diabetes. Body mass index, waist and hip volume, as well as physical tolerance by means of Bicycle ergometry and 6-minute walk test were evaluated. Indicators of carbohydrate and lipid metabolism wer e determined, insulin resistance index was calculated.Results. At the end of 16-week therapy, physical tolerance according toVEM in group 1 increased by 29.67% (p<0.01), in group 2-by 9.14% (p>0.05). The distance during the 6-minute walk test was significantly increased in both groups: by 34.37% and by 25.80%, respectively. Patients of group 1 had a significant decrease in BMI by 11.52%, postprandial glucose level by 19.38% (p = 0.018), insulin by 18.90%, glyca ted hemoglobin (HbA1c) by 13.21%, insulin resistance index by 17.65%, triglyceride by 14.14% (p<0.05), low density lipoprotein cholesterol by 16.05% (p<0.01).), aspartate aminotransferases and alanine aminotransferases – by 27.75% and 16.52%, respectively.Conclusion. Sup plement taurine standard therapy of coronary heart disease associated with type 2 diabetes mellitus, in patients who have undergone endovascular myocardial revascularization, has a positive effect on the performance of carbohydrate and lipid metabolism, reduces body weight, improves physical performance.
The 1930-s Unrealized Projects on Development of Gorky City (Nizhny Novgorod)
Authors: Orelskaya Olga V. 
Published: September 2018

The article deals with little-known unrealized projects shaping the image of the socialist Gorky city, its river panoramas, squares and highways in accordance with the first Soviet master plan of 1935-1937, made by the creative collective of Leningrad Giprogor, under theleadership of N.A. Solofnenko. The development of the master plan of alarge city was based on the principles of reconstruction of the General plan of Moscow in 1935. The architecture of a post-avant-garde epoch allowed to clearly demonstrate the architectural searches of the period, identify their characteristics, their mistakes and achievements.
A radical reconstruction of an ancient city assumed a demolition of historic buildings. Instead of the lost town­planning dominants - churches that adorned the river facades of the city for many centuries, architects offered new high-rise accents in the form of monumental public buildings. Projects with classical compositions of central squares contributed to the formation of a fundamentally new image of the city. The tendencies of monumentalism appeared under the influence of well-known projects of accomplishment and organization of urban spaces in the capital cities - Moscow and Leningrad. This was an important phase of the new appeal to historicism, namely the development of the classics, which began in the mid 1930-ies and ended in the mid-1950s Archival photographs of 1930-ies complement the history of Russian Soviet architecture and urban planning and disclose the concept of the planned ambitious reforms.
Theoretical Models of Modern Suburban Recreational Complexes
Authors: Bolyaeva Ksenia O. 
Published: September 2018

The article discusses aspects of the formation of theoretical models of modern suburban recreational complexes (SRC). The recreational environment is defined as result of interaction, interpenetration and mutual addition of three complex factors: recreational activity, recreational resources and recreational structures. Definition of SRC as the local system of recreational suburban formations of various functional profiles consisting of recreational structures is given. SRC is distinguished by taxonomic and typological features. The taxonomic feature determines the position of the SRC in the scale of rank of the recreational formations system. The typological feature indicates qualitative differences in the recreational formations of a single taxonomic rank.
The analysis of examples of completed SRC allows us to distinguish the basic theoretical models of modern SRC, depending on thelocation of the recreation object. Specific features of the formation of a specialized recreational layout of the SRC are revealed: closed, half-closed, half-open and open. SRC of the closed type contain the full list of necessary rooms for performance of recreational function and don't demand connection with recreational facilities of the region. SRC of half-closed type perform one dominating recreational function with partial use of recreational resources of the area. SRC of half-open type assumes only auxiliary recreational group and operate recreational resources of the area to perform the main recreational function. SRC of open type assume only placement and incidental service and are completely focused on recreational resources of the area.
The specificity of contemporary types of SRC is the position of the main recreation object relative to the SRC itself. The object of recreation within the SRC is formed by a specialized recreational group, which sets the orientation of the SRC.
The Role of Technological Structures in the Formation of Agglomerations
Authors: Mazaev Grigory V. , Mazaev Anton G. , Verkhovikh Elena Y. 
Published: September 2018

The article on the example of the city of Yekaterinburg and a number of other industrial cities of the Middle Urals shows the role and influence of the technological structures of different generations on the formation of the planning structure of large and largest industrial cities. The development of Ekaterinburg's planning has been shown, since the 18th century, the process of the formation of agglomeration around it since the 30s of the XX century has been considered.

The article also considered the agglomeration effect, which develops in the planning of industrial cities when they create enterprises of III and IV technoLogicaL structures. Under his action, the planning system of the "city-agglomeration" is formed, as a specific form of development of the largest city. The authors for the first time proposed this new concept in urban planning theory, which makes it possible to characterize the development of a spatially distributed city with a set of reLativeLy isoLated parts, which in this particuLar case is manifested through the so-called system of socialist cities. The role of these socialist cities in the formation of a "city- agglomeration" is considered, the phenomenon of local self­identification of their inhabitants is shown, which consider their isolated region as a territorial entity existing separately from the central planning area, which is identified by the inhabitants of the "metropolitan city" with the notion of "city".
The phenomenon of the withdrawal of industrial sites mainly from the central planning zones of the largest industrial cities is considered. The conditions for the development of the agglomeration effect for thelargest cities are determined, this effect was classified in the Scheme of the appearance of agglomeration effect in city planning. The final conclusion is made that the phenomenon of formation of a "city-agglomeration" should be taken into account in the development of master plans of industrial cities as a potential opportunity for the development of their planning structures, which affects the development of transport and social infrastructures.
Determinan Penyakit Asma pada Pekerja Usia Produktif di Indonesia, Riset Kesehatan Dasar 2013
Authors: Tana Lusianawaty 
Published: September 2018

AbstractAsthma is one of the chronic respiratory diseases that often leads to decrease of productivity, loss ofincome and unemployment, as well as psychosocial and financial problems. The objective of the researchwas to identify the determinants of asthma of productive age workers in Indonesia using Basic HealthResearch (Riskesdas 2013). Sampling criteria were workers aged 15-64 years across the country. Thedata were analyzed by complex sample with significance level of 0.05 and 95% confidence intervals.Samples that met the criteria were 405.984 people. Determinants of asthma were areas of residence,age, education, nutritional status, smoking, illumination sources, sex, occupation, ownership index,residence location, slum neighborhood, physical activity, and fuel type usage. (OR adj 1.1-2.1 p≤0.01).The proportion of asthma in eastern region of Indonesia and Java-Bali region were 2.05 and 1.75 higherthan Sumatra region respectively. Less nutritional status had asthma proportion of 1.5 times higher thannormal. Improving nutritional status and increasing knowledge about healthy lifestyle should be done asan effort to reduce the occurrence of asthma.Key words: workers, asthma, Indonesia, Riskesdas 2013

AbstrakAsma merupakan masalah kesehatan di semua Negara dan salah satu penyakit saluran pernapasankronik yang sering mengakibatkan turunnya produktifitas, hilangnya pendapatan income dan pekerjaan,serta menimbulkan masalah psikososial dan keuangan. Tujuan analisis lanjut menentukan determinanpenyakit asma pada pekerja usia produktif di Indonesia, menggunakan data Riskesdas Tahun 2013.Kriteria sampel: berusia 15-64 tahun dan status bekerja. Variabel yang di analisis meliputi asma,karakteristik individu, perilaku, dan tempat tinggal. Analisis data menggunakan kompleks sampel,tingkat kemaknaan ≤0,05 dan confidence interval 95%. Jumlah sampel sesuai kriteria 405.984 orang.Determinan asma adalah kawasan tempat tinggal, umur, pendidikan, status gizi, merokok, sumberpenerangan, jenis kelamin, pekerjaan utama, indeks kepemilikan, lokasi tempat tinggal, lingkungankumuh, aktivitas fisik, dan jenis bahan bakar. (ORadj 1,1-2,1 p≤0,01). Persentase asma lebih tinggi diKawasan Timur Indonesia 2,05 kali dan Jawa-Bali 1,75 kali dibandingkan Sumatera, pada status gizikurang 1,5 kali dibandingkan normal, umur 55-64 tahun 1,5 kali dibandingkan umur 15-24 tahun, padapendidikan rendah 1,5 kali dibandingkan pendidikan tinggi. Perbaikan status gizi dan peningkatanpengetahuan tentang hidup sehat perlu dilakukan sebagai upaya menurunkan kejadian asma.Kata kunci: pekerja, asma, Indonesia, Riskesdas 2013
Regional Differentiation of Farm Profitability in Poland during 2006-2014
Authors: Nowak Anna , Kijek Tomasz 
Published: September 2018

Abstract
Subject and purpose of work: The aim of the study is to assess the regional differentiation of the average level of farm income and to answer the question of whether during 2006-2014 there was a tendency towards convergence in this area. Materials and methods: The spatial scope of research included four FADN agricultural regions, whereas the time span covered the years 2006-2014. The numerical data used for the analyses were sourced from standard FADN results. The assessment of convergence was carried out using the coefficient of variation (sigma convergence) and the relative index of changes in the regions compared to the country (beta convergence). Results: The conducted research indicates the existence of regional disproportions in terms of average income level and average labour profitability on farms. The highest average income was achieved throughout all the years covered by research in the region of Pomerania and Masuria, and the lowest one in Lesser Poland and Carpathian Foothills. The research demonstrates that during 2006-2014 there was no convergence in the average level of income and average labour profitability of farms in the FADN regions. Conclusions: Convergence is a long-term process, so the research should be treated as an initial examination of the regional differentiation of the income situation of farms.
Multi- and In-Stabilities in Gas Partitioning Between Nanoporous Materials and Rubber Balloons
Authors: Simon Cory , carraro carlo 
Published: September 2018

In the two-balloon experiment, two rubber balloons are connected and allowed to exchange gas. Owing to the non-monotonic relationship between the radius of the balloon and the pressure of gas inside of it, the two-balloon system presents multi- and in-stabilities.Herein, we consider a two-adsorbent system, where two different adsorbents are allowed to exchange gas. We show that, for rigid adsorbents, the thermodynamic equilibrium state is unique.Then, we consider an adsorbent-balloon system, where an adsorbent exchanges gas with a rubber balloon. This system can exhibit multiple states at thermodynamic equilibrium-- two (meta)stable and one unstable. The size of the balloon, pressure of gas in the balloon, and partitioning of gas between the adsorbent and the balloon differ among the equilibrium states. Temperature changes and the addition/removal of gas into/from the adsorbent-balloon system can induce catastrophe bifurcations and show hysteresis. Furthermore, the adsorbent-balloon system exhibits a critical temperature where, when approached from below, the discrepancy of balloon size between the two (meta)stable states decreases and, beyond, bistability is impossible.Practically, our findings preclude multiple partitions of adsorbed gas in rigid mixed-linker metal-organic frameworks and may inspire new soft actuator and sensor designs.
A Lei do Teto e seus possíveis reflexos nas unidades de informação
Authors: Cunha Murilo Bastos da 
Published: September 2018

O editorial comenta os possíveis efeitos da nova legislação brasileira, denominada Lei do Teto de Gastos, nas unidades de informação (bibliotecas, arquivos e museus). Além disso, são comentados os artigos incluídos no primeiro número de 2018 da Revista Ibero-Americana de Ciência da Informação.
Métricas para Dados Governamentais Abertos
Authors: Silva Patrícia Nascimento , Pinheiro Marta Macedo Kerr 
Published: September 2018

Os empreendimentos de dados abertos iniciados em 2009 trouxeram um novo contexto sobre o reuso de Dados Governamentais Abertos (DGA). As informações do governo são fonte para diversos produtos de informação e seu potencial, ainda pouco explorado, tem sido cada vez mais valorizado pelos cidadãos, empresas e pelos próprios governos. Esta pesquisa exploratória, com abordagem qualitativa, tem o objetivo de realizar uma revisão de literatura para investigar a experiência de outros países com relação a métricas, indicadores e modelos para avaliar os DGA disponibilizados. As métricas podem ser utilizadas pelos consumidores e principalmente pelos produtores de DGA para avaliar o retorno do investimento e dos esforços relativos Ã abertura de dados. As métricas apresentadas foram: Metric for Releasing Open Data, Open Data Maturity Model, OpenGovB e a Norma UNE 178301. Conclui-se que as métricas, apesar de possuírem muitas variáveis de avaliação, não estabelecem uma clareza em sua definição, nem justificam os percentuais e pontos atribuídos a cada variável. Porém, como ainda são instrumentos recentes, sua utilização poderá conduzir a um maior grau de maturidade. Além dos governos se beneficiarem do uso dessas métricas, elas poderão ser utilizadas e adaptadas a outros países e contextos da sociedade.
Avaliação e enriquecimento semântico de ontologia com base na comparação a um corpus: um estudo de caso no domínio da agricultura
Authors: Araújo Webert Júnio , Lima Gercina Ângela de 
Published: September 2018

Este estudo é resultado da dissertação de mestrado que apresenta uma pesquisa sobre avaliação de ontologia. O objetivo norteador foi avaliar uma ontologia de domínio por meio de uma proposta de avaliação baseada na comparação a um corpus de texto e a partir da avaliação propor o enriquecimento semântico. A ontologia que se propôs avaliar neste trabalho foi desenvolvida no âmbito da EMBRAPA Campinas, denomina-se OntoAgroHidro e representa o impacto das mudanças climáticas na agricultura e nos recursos hídricos. A metodologia da pesquisa se respaldou em uma proposta de avaliação de ontologias desenvolvida por Brewster et al. (2004), que foi adaptada para o contexto do estudo e possui quatro etapas: 1) definição das questões de competência; 2) seleção da coleção de documentos que compõe o corpus para avaliação da ontologia; 3) seleção das expressões relacionadas aos conceitos das questões de competência; 4) avaliação e inclusão das expressões na ontologia. Os resultados demonstraram que a ontologia avaliada apresentou um percentual de aproximadamente 70% dos conceitos do corpus selecionado para avaliação. Os resultados também indicaram particularidades na representação de conceitos pela OntoAgroHidro. Conclui que a avaliação de ontologia aplicada foi satisfatória, pois permitiu identificar vários pontos de melhoria na ontologia avaliada.