bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nano‐sensor Based on MoS2 Nanosheet mixed with Au quantum dot: Role of Layer Number and Temperature
Authors: Lou Xue , Zhang Li‐quan , Liu Qing‐hui , Wang Ying‐hui , Yao Lian‐Fei , Wang Yan‐ting , Kang Zhi‐hui , Zhou Qiang , Zhang Han‐Zhuang 
Published: December 2018

AbstractThe performance of nano‐sensor based on MoS2 nanosheet mixed with Au particle is tested based electrochemical test involving cyclic voltammogram and impedance spectroscopy, where the FeIII(CN)63−/FeII(CN)64− and dopamine (DA) are chosen as research object to verify the role of layer number of MoS2 nanosheet and the temperature. The electrochemical test shows the Au nanoparticle would improve the electron exchange reaction occurring on the electrode. In the solution of FeIII(CN)63−/FeII(CN)64−, the electrode reaction follows
, where increasing the layer number of MoS2 nanosheet would restrict the reaction. In the DA system, the reaction of
occurs on the electrode and increasing the layer number of MoS2 nanosheet would facilitate the reaction. The difference as mentioned above is assigned to the energy level shift originated from variance of layer number of MoS2 nanosheet and the changing of reaction mechanism. In addition, temperature would mainly facilitate the kinetics of electron exchange reaction, which is assigned to the diffusion acceleration of DA molecule. Simultaneously, the desorption process of reactant in the electrolyte would enhance. The role of layer number of MoS2 nanosheet and the temperature is clarified with the thermodynamic and kinetic properties of electron exchange reaction based on MoS2 nanosheet, which would improve the understanding of nano‐sensor based on MoS2 nanosheet.
Electrochemical Sensing Platform Based on Nano‐Perovskite/Glycine/Carbon Composite for Amlodipine and Ascorbic Acid Drugs
Authors: Atta Nada F. , El‐Ads Ekram H. , Galal Ahmed , Galal Aya E. 
Published: December 2018

AbstractPeople suffered from essential hypertension have increased oxidative stress. Thus, adding vitamin C to their medical therapy resulted in decreasing the oxidative stress and increasing the antioxidant status. This may prevent further vascular damage due to the oxidative stress, leading to a better diagnosis in critical hypertension patients. A novel sensor was fabricated based on NdFeO3nano‐perovskite/glycine/carbon nanotubes modified carbon paste electrode in presence of sodium dodecyl sulfate; GLNFCNTCP‐SDS for electrochemical sensing and simultaneous determination of antihypertensive and antioxidant drugs, Amlodipine (AML) and ascorbic acid. The developed nanocomposite showed interactive characteristics of all the modifiers as high conductivity, enhanced surface area, surface fouling resistance and stability. This leads to accelerated electron transfer rate and increased current response of electro‐oxidation of AML by 8.3 folds compared to unmodified electrode. The method validity was investigated successfully by the quantitative analysis of AML in human urine samples and Norvasc tablets with acceptable recovery results. The featured merits of the proposed composite in the analysis of AML in human urine samples were; wide concentration range of 0.003 μmol L−1to 200 μmol L−1, sensitivity of 113.2 μA/μmol L−1, detection limit of 0.704 nmol L−1, and quantification limit of 2.35 nmol L−1.
Construction and Electrochemical Property Studies of DNA Duplexes Tethered to Gold Electrode via Au−C Bond
Authors: Zhang Meng , Chen Jia , Pi Xiaomei , Deng Chunyan , Xiang Juan 
Published: December 2018

AbstractEffective linkage of DNA onto metal surfaces plays a crucial role in the applications of DNA as electrochemical recognition, signal output and amplification devices for gene and protein detections, specific analyte recognitions, catalysis, and so on. Here we report a promising and operationally simple approach for the construction of double‐stranded DNA‐linked Au interface via Au−C bond (RdsDNA‐C−Au), upon efficient in situ cleavage of trimethylsilyl end group of 4‐[(trimethylsilyl) ethynyl] benzoic acid and subsequent dehydration condensation between NH2‐modified DNA and benzoic acid. Due to the introduction of large conjugated π group (4‐carboxyphenylethynyl) as the “bridge bond”, the conductivity of the RdsDNA‐C−Au interface is greatly improved. As a result, under commonly used DNA packing density (>0.5 pmol cm−2), the surface‐confined electron transfer at the interface is simply mediated by the stacked‐bases of dsDNA, independent of the orientation of dsDNA (tethered to the electrode at 5′‐ or 3′‐end). Also, compared to the traditional RdsDNA‐S−Au interface via alkanethiol linker, the RdsDNA‐C−Au interface displays more sensitive electrochemical response and excellent stability. Due to the better stability, conductivity and simple electron transfer mechanism, the RdsDNA‐C−Au interface is anticipated to be widely used in electrochemistry‐involved molecular recognitions, gene and protein detections with higher sensitivity and accuracy.
An Amorphous MnO2/Lithiated NiO Nanosheet Array as an Efficient Bifunctional Electrocatalyst for Iron Molten Air Batteries
Authors: Liu Shuzhi , Gao Shengyao , Cui Baochen , Xiang Wei , Liu Xianjun , Han Wei , Zhang Jianhua 
Published: December 2018

Iron molten air battery is considered one of the promising batteries in next‐generation energy storage due to high theoretical specific energy density, cost efficiency, and environment‐friendly merits. Herein, an amorphous MnO2/lithiated NiO nanosheet array is grown directly on a highly conductive nickel foam substrate to use as a bifunctional electrocatalyst in iron molten air batteries. The advantages of the nanosheet array structure are having more highly exposed active sites for electrochemical reactions, as well as a conductive stable 3D framework for allowing barrier‐free diffusion and transport of ions and oxygen gas. As a result, the amorphous MnO2/lithiated NiO nanosheet array exhibits a promising catalytic activity for oxygen evolution reaction and oxygen reduction reaction with a voltage gap of only 0.29 V. The as‐assembled iron molten air battery shows an impressive rechargeability with the highest coulombic efficiency of nearly 100% through 200 cycles with an average discharge potential of ≈1.14 V at 500 °C. Moreover, the cell has a high rate response up to 6.7 C with a discharge voltage of above 0.9 V. The study achieves critical advances for iron molten air batteries without the use of precious metals in contrast with previous results using the Pd‐based catalyst.
Automated Solid‐Phase Microextraction GC‐MS/MS Method for Quantification of Volatile Limonene Oxidation Products in Encapsulated Orange Oil
Authors: Emberger Matthew E. , Lin Jianming , Pika Jana , Christ Ingo , Eigenbrodt Bryan 
Published: December 2018

AbstractLimonene, widely present in consumer products, is prone to oxidation and leads to the formation of undesirable reaction products. A solid‐phase microextraction (SPME) GC‐MS/MS method was developed for the quantification of volatile limonene oxidation products, in encapsulated oil samples, by the optimization of MS parameters and SPME sampling conditions including fibre coating, temperature and time. The detection limit of the method reached 10 to 15 ppb for the limonene oxides, and less than 5 ppb for carvone and carveol isomers. Standard addition calibration was utilized to compensate for matrix effects of the encapsulation, flavouring, and to optimize the accuracy and versatility of this method. Sample throughput and precision of the method were improved through in‐line automated SPME sample preparation. The popularity of limonene as a flavouring compound in many consumer products, allows this method to be adapted to quantify different levels of volatile limonene oxidation products in encapsulated matrices.
Effect of ice water pretreatment on the quality of Pacific White Shrimps (Litopenaeus vannamei)
Authors: Xu Nan , Shi Wenzheng , Wang Xichang , Wang Zhihe 
Published: December 2018

AbstractPacific White Shrimps (Litopenaeus vannamei) are an aquaculture species with global importance. For the purpose of this paper, the quality shelling process of Pacific White Shrimps, freshly harvested from farms and stored in a mixture ice water up to 24 hr, was investigated. Both the differences and correlations between the indexes such as peeling time, shrimp yield, chromatic aberration, texture, K value, TBA value, and microstructure were compared and analyzed. The optimal shell peeling time of Pacific White Shrimps was determined by ice water treatment for 8 hr. The shell peeling time was 1.77 min, the elasticity of the shrimp was 0.51 mm, the hardness was 2,124.58 g, K value was 1.33%, and TBA value was 0.004 mg/100 g. Both the smell and color of the shelled shrimp were normal. This study aims to endorse the mechanical shelling of Pacific White Shrimps.
Nd and Sr isotopic composition of ancient iron‐made artifacts and ores from northwest Russia
Authors: Felitsyn Sergey B. , Alfimova Nadezhda A. , Bogomolov Eugene 
Published: December 2018

AbstractIron‐made artifacts from northwest Russia, including nails, arrowheads, and brackets used in the 13th–19th centuries, have a wide range of Sr and Nd isotopic composition (87Sr/86Sr = 0.710–0.737 and 143Nd/144Nd = 0.5115–0.5124). Authigenic iron ore sites mined in the region from 10th to 19th centuries preserve a similar range of isotopic compositions, suggesting artifacts retain the Sr and Nd signatures of their parent ores. Analyses of the ores also reveal two broad regions distinguished by their isotopic compositions, with the Precambrian Baltic craton in the northern part of the region having very radiogenic Sr and unradiogenic Nd isotopic compositions (87Sr/86Sr >0.7177 and 143Nd/144Nd <0.5119) compared with ores from the Paleozoic sedimentary cover of the East European platform to the south. The recognition of distinct geochemical provinces permits identification of the broad regions from which the various ores were mined, and demonstrates the utility of applying radiogenic isotopic analyses to artifacts and their potential geologic sources.
Geotechnical challenges during the construction of the Albabstieg Tunnel in prediction and construction
Authors: Wunderle Maximilian , Abele Matthias 
Published: December 2018

AbstractThe construction of the Albabstieg Tunnel on the Wendlingen–Ulm railway line had to overcome several geotechnical challenges. For the filling of the ground replacement body as a foundation for the slab track from recycled tunnel excavation material, it turned out that the Jurassic limestones are only conditionally suitable as a qualified fill material. The aggregates processed on site can only be used as fill material if cement stabilised. Beside the main issue of karst investigation, above ground by means of geophysical methods and underground using a conventional drilling grid, two longer sections of pipe screens had to be constructed: in the area of an unsealed landfill intersected by the tunnel cross‐section and in the area of shallow overburden in the Lehrer Tal. Tunnelling under a residential area with historic cellars had to be accompanied by an intensive monitoring of blasting due to highly variable rock strength. Low‐emission tunnelling could only be achieved with additional measures of blasting optimization. With the interdisciplinary co‐operation between client, geotechnical consultant, designer and contractor, these special challenges were successfully overcome and the construction works were completed within cost and schedule.
Image‐based discontinuity identification
Authors: Buyer Andreas , Pischinger Gerald , Schubert Wulf 
Published: December 2018

AbstractKnowledge about the joint network is important in rock engineering. It controls the stability and strength of blocky rock masses. Thus, the joint network is mapped in more or less detail, regarding the specifications. To do so, different methods have evolved over the years. One of these methods is digital mapping, based on the visual and spatial appearance of the distinct joints. This mapping usually is done by an experienced geologist. However, the trend in digital mapping is towards a supervised but mainly autonomous identification of discontinuities. One aspect of this automated process is the recognition of joints in digital outcrop images by their optical attributes. This contribution presents a density based joint plane detection. By the combination of a vector based joint plane detection and a pixel based joint trace detection, not only joints, but also the foliation in the investigated tunnel face could be extracted very accurately. The approach represents the current state of research and further improvements are to be expected.
Smarter Tunnelling
Authors: Füllenbach Christel 
Published: December 2018

AbstractSafety, time and costs belong to the most important influencing factors in tunnelling. The Smarter Tunnelling concept can positively influence these factors by speeding up work processes, avoiding limited safety zones and saving time and money. Smarter tunnelling not only describes the use of machines that are remotely monitored, but also the integration of an entire intelligent system into a tunnelling project. For this purpose, all machines used have to communicate with each other and with a central data processing unit. To implement this digitization and automation in tunnelling projects, networking with intelligent sensors and actuators as well as special software are used. In order to achieve a trimming of work processes at the same time, it is necessary to streamline data processing through IT solutions. This paper presents the Epiroc solutions, which have been specially developed for the tunnel construction sector.
Selecting appropriate focal species for assessing the risk to birds from newly drilled pesticide-treated winter cereal fields in France
Authors: Bonneris Emmanuelle , Gao Zhenglei , Prosser Amanda , Barfknecht Ralf 
Published: December 2018

Abstract

Identifying focal bird species appropriate to the situation in which a plant protection product is used is important for refined risk assessment (EFSA 2009). We analyzed the results of extensive field observations of newly drilled cereal fields in France in autumn over 2 seasons to determine real bird focal species. In 2011, birds were observed before and after drilling on wheat and barley fields drilled with imidacloprid-treated seeds (i.e., “treatment” fields) or seeds treated with compounds other than imidacloprid (i.e., “alternative treatment” fields). Bird abundance, species richness, and diversity were significantly higher in wheat fields than barley fields; these findings led us to monitor only wheat fields in 2012. Statistical analyses did not show a significant effect of the drilling itself or between the treatment fields and the alternative treatment fields on the number and type of bird species. These results led to the pooling of 2011 data on all fields for focal species determination. Similarly, all bird monitoring data generated in 2012 before and after drilling were pooled and analyzed. Rules for determination of candidate focal species detailed in the EFSA (2009) guidance were followed. Carrion crow, wood pigeon, gray partridge, skylark, common starling, and pied wagtail were the bird species most frequently observed on wheat fields. This list of candidate species was processed to determine the most relevant focal species according to the method of Dietzen et al. (2014); this process resulted in the selection of skylark, gray partridge, wood pigeon, and pied wagtail as focal species to assess risks to birds for pesticides applied during drilling of winter cereals in France (September through November). Integr Environ Assess Manag 2019;00:000–000. © 2018 The Authors. Integrated Environmental Assessment and Management published by Wiley Periodicals, Inc. on behalf of Society of Environmental Toxicology & Chemistry (SETAC)
Retracted: MicroRNA‐21 contributes to high glucose–induced fibrosis in peritoneal mesothelial cells in rat models by activation of the Ras–MAPK signaling pathway via Sprouty‐1
Authors: Gao Qing , Xu Lin , Yang Qian , Guan Tian‐Jun 
Published: December 2018

AbstractPeritoneal fibrosis remains to be one of the most severe causes of failure in continuous peritoneal dialysis. The current study cultured peritoneal mesothelial cells in high glucose to stimulate the environment of peritoneal fibrosis model in rats, and investigate whether microRNA‐21 (miR‐21) targeting Sprouty‐1 affects high glucose–induced fibrosis in peritoneal mesothelial cells via the rennin angiotensin system (Ras)–mitogen‐activated protein kinase (MAPK) signaling pathway, as well as potential mechanisms. Peritoneal tissues in fibrosis rats were collected to extract peritoneal mesothelial cells, which, after in vitro culture, were transfected with a series of mimic or inhibitor of miR‐21, or the small interfering RNA (siRNA) against Sprouty‐1. Reverse‐transcription quantitative polymerase chain reaction and western blot analyses were performed to determine the levels of related genes or proteins. MTT assay and flow cytometry were conducted to observe the cell viability and cell apoptosis of peritoneal mesothelial cells. Dual‐luciferase reporter gene assay revealed that Sprouty‐1 is the target gene of miR‐21. Peritoneal fibrosis manifested with elevated miR‐21, extracellular‐signal‐regulated kinase (ERK), c‐Jun NH2‐terminal protein kinase (JNK), RAS and p38MAPK but reduced Sprouty‐1. Cells transfected with miR‐21 mimic exhibited decreased Sprouty‐1 expressions, but increased levels of ERK, JNK, RAS, and p38MAPK. As for cellular process, miR‐21 mimic or siRNA against Sprouty‐1 exposure reduced cell viability, which resulted in more cells arrested at the G1 stage, and induced apoptosis. In contrast, miR‐21 inhibitor exposure was observed to have induced effects on peritoneal mesothelial cells. These key findings provide evidence that miR‐21 inhibits Sprouty‐1 to promote the progression of fibrosis in peritoneal mesothelial cells by activating the Ras–MAPK signaling pathway.
Membrane‐tethered Notch1 exhibits oncogenic property via activation of EGFR–PI3K–AKT pathway in oral squamous cell carcinoma
Authors: Zheng Yang , Wang Zhao , Xiong Xianbin , Zhong Yi , Zhang Wei , Dong Yibo , Li Jialiang , Zhu Zaiou , Zhang Wei , Wu Heming , Gu Wenyi , Wu Yunong , Wang Xiang , Song Xiaomeng 
Published: December 2018

AbstractNotch proteins are highly conserved cell surface receptors which play essential roles in cellular differentiation, proliferation, and apoptotic events at all stages of development. Recently, NOTCH1 mutations have been extensively observed in oral squamous cell carcinoma (OSCC) and are hinted to be Notch1‐inactivating mutations. However, little is known about the biological effect of these reported mutations in OSCC. To mimic the inactivation of Notch1 due to inappropriate mutations and to determine the potential mechanisms, we utilized wild‐type Notch1 vectors (Notch1WT) or mutant Notch1 vectors (Notch1V1754L) to transfect into OSCC cell lines. Membrane‐tethered Notch1 induced by mutation was analyzed by immunofluorescence staining. γ‐Secretase inhibitor PF‐03084014 was utilized to determine the phenotype in the absence of endogenous Notch1 activation. Here we demonstrated that membrane‐tethered Notch1 inactivated the canonical Notch1 signaling and oncogenic phenotypes were identified by promoting cell proliferation and invasion and by inducing epithelial‐to‐mesenchymal transition in cells. The γ‐secretase inhibitor PF‐03084014 also showed distinct oncogenic property after treatment. Importantly, both membrane‐tethered Notch1 and PF‐03084014 inhibitor activated the epidermal growth factor receptor (EGFR)–phosphoinositide 3‐kinase (PI3K)–protein kinase B (AKT) signaling pathway, which has been confirmed as an overwhelming modulator in OSCC. This was the first time that we clearly simulated the mutated Notch1 activities and determined the oncogenic phenotypes of membrane‐tethered Notch1. Compared with wild‐type Notch1, membrane‐tethered Notch1 was strongly associated with activated EGFR–PI3K–AKT signaling pathway.
Challenges facing antiangiogenesis therapy: The significant role of hypoxia‐inducible factor and MET in development of resistance to anti‐vascular endothelial growth factor‐targeted therapies
Authors: Mahdi Ali , Darvishi Behrad , Majidzadeh‐A Keivan , Salehi Malihe , Farahmand Leila 
Published: December 2018

AbstractIt is now fully recognized that along with multiple physiological functions, angiogenesis is also involved in the fundamental process and pathobiology of several disorders including cancer. Recent studies have fully established the role of angiogenesis in cancer progression as well as invasion and metastasis. Consequently, many therapeutic agents such as monoclonal antibodies targeting angiogenesis pathway have been introduced in clinic with the hope for improving the outcomes of cancer therapy. Bevacizumab (Avastin®) was the first anti‐vascular endothelial growth factor (VEGF) targeting monoclonal antibody developed with this purpose and soon received its accelerated US Food and Drug Administration (FDA) approval for treatment of patients with metastatic breast cancer in 2008. However, the failure to meet expecting results in different follow‐up studies, forced FDA to remove bevacizumab approval for metastatic breast cancer. Investigations have now revealed that while suppressing VEGF pathway initially decreases tumor progression rate and vasculature density, activation of several interrelated pathways and signaling molecules following VEGF blockade compensate the insufficiency of VEGF and initially blocked angiogenesis, explaining in part the failure observed with bevacizumab single therapy. In present review, we introduce some of the main pathways and signaling molecules involved in angiogenesis and then propose how their interconnection may result in development of resistance to bevacizumab.
Let‐7e enhances the radiosensitivity of colorectal cancer cells by directly targeting insulin‐like growth factor 1 receptor
Authors: Samadi Pouria , Afshar Saeid , Amini Razieh , Najafi Rezvan , Mahdavinezhad Ali , Sedighi Pashaki Abdolazim , Gholami Mohammad Hadi , Saidijam Massoud 
Published: December 2018

AbstractAbnormal expression of various microRNAs (miRNAs), as regulators of biological signaling pathways, has a strong association with cancer resistance to chemotherapy and radiotherapy. The let‐7 family of miRNAs as tumor suppressors have shown to be downregulated in different types of human malignancies including colorectal cancer (CRC). However, the biological function of let‐7 members in the processes of resistance to radiation in CRC has not yet been completely elucidated. Insulin‐like growth factor 1 receptor (IGF‐1R) signaling pathway is amplified in CRC and leads to its progression, development, and also radiation resistance. So, it seems like an attractive target for anticancer therapy. In this study, by using bioinformatics analysis, it has been revealed that IGF‐1R is a direct target of the let‐7e member. Consistent with this, we identified that increased levels of let‐7e in CRC cells reduced IGF‐1R protein level and subsequently its downstream signaling pathways, which resulted in the G1 cell cycle arrest and a significant reduction in the proliferation, survival and also resistance to radiation of CRC cells. Altogether, these results suggested that let‐7e by targeting the IGF‐1R signaling pathway might serve as therapeutics in anticancer therapy.