bluuebunny/crossref_metadata_2025_split huggingface dataset:
Learning to “brave up”: Collaboration, agency, and authority in multicultural, multilingual, and radically inclusive classrooms
Authors: Dover Alison G. , Rodriguez-Valls Fernando 
Published: October 2018

The Summer Language Academy (SLA) is an innovative and intensive summer program for high-school aged newcomers/new Americans, English learners, and emergent bilinguals, as well as for teachers working with them. In the SLA, students and educators collaboratively explore questions of identity, language, and culture through high-interest texts, arts-based curriculum, and redefinition of teaching and learning as reciprocally shared endeavors. In this article, we examine SLA implementation and impact in two neighboring districts, focusing on the opportunities and tensions that arise when new and veteran educators are challenged to increase their consciousness and capacity regarding multicultural, multilingual, and radically inclusive teaching.
Análise da evolução dos parâmetros de dimensionamento de reservatórios em concreto: estudo de caso
Authors: Corrêa Patricia Da Rosa Dorneles , Girardi Ricardo 
Published: October 2018

Reservatório de concreto é uma unidade hidráulica de acumulação e passagem da água que deve ter uma vida útil para cumprir a função para qual foi projetado. Para tanto, é essencial que a estrutura apresente estanqueidade, que é possível quando o projeto e execução respeitem características como resistência à compressão do concreto, cobrimento mínimo de armadura, relação água/cimento, adequada impermeabilização da estrutura. Não ocorrendo tais características, o concreto pode deteriorar e a armadura ficar sujeita à corrosão, quando a água reservada possuir cloretos, sulfatos em altos teores e baixo pH, entrando em contato com o concreto através de poros ou fissuras. A partir do método indutivo, com a análise documental, o presente estudo objetivou uma análise histórica da atual NBR 6118, desde 1940, e as Portarias do Ministério da Saúde sobre uso de cloro e sulfato, a fim relacionar os parâmetros usados no projeto dos reservatórios com a degradação dessas estruturas. O estudo de dezenove reservatórios de concreto, dentro de um horizonte de trinta e nove anos, demonstrou inicialmente que os parâmetros de projeto de norma e parâmetros físico químicos evoluíram a favor da segurança dessas estruturas. E finalmente, para o dimensionamento dos reservatórios não foram respeitadas as características de projeto, favorecendo o início da corrosão nas armaduras.
Prediction of RNA Pseudoknotted Secondary Structure using Stochastic Context Free Grammars (SCFG)1
Authors: García Rafael 
Published: October 2018

Pseudoknots are a frequent RNA structure that assumes essential roles for varied biocatalyst cell’s functions. One of the most challenging fields in bioinformatics is the prediction of this secondary structure based on the base-pair sequence that dictates it. Previously, a model adapted from computational linguistics – Stochastic Context Free Grammars (SCFG) – has been used to predict RNA secondary structure. However, to this date the SCFG approach impose a prohibitive complexity cost [O(n4)] when they are applied to the prediction of pseudoknots, mainly because a context-sensitive grammar is formally required to analyze them. Other hybrids approaches (energy maximization) give a O(n3)complexity in the best case, besides having several restrictions in the maximum length of the sequence for practical analysis.
Here we introduce a novel algorithm, based on pattern matching techniques, that uses a sequential approximation strategy to solve the original problem. This algorithm not only reduces the complexity to O(n2logn), but also widens the maximum length of the sequence, as well as the capacity of analyzing several pseudoknots simultaneously.
Development and Evaluation of a Global Burnout Index Derived from the Use of the Copenhagen Burnout Inventory in Portuguese Physicians
Authors: Lapa Teresa , Carvalho Sérgio , Viana Joaquim , Ferreira Pedro Lopes , Pinto-Gouveia José , Belo-Cabete Adriana 
Published: October 2018

Introduction: The Copenhagen Burnout Inventory was developed to overcome what some authors have proposed as potential limitations of existing burnout measures. Specifically, the Copenhagen Burnout Inventory measures the main component of burnout (i.e. exhaustion) in three domains: personal-, work- and patient-related. Additionally, some authors have argued the necessity to have available a global burnout index.Material and Methods: This study followed a cross-sectional design in a sample of Portuguese physicians (n = 1348). A confirmatory factor analyses was conducted and the Copenhagen Burnout Inventory´s three-factor structure was tested. In addition, a model with a 2nd order factor was tested with the goal of achieving a one-factor structure that would allow a global burnout index.Results: The confirmatory factor analyses showed a good model fit for both the three-factor and one-factor model, having the latter a significant better fit. The Copenhagen Burnout Inventory showed good psychometric properties for both structures, with good reliability according to Chronbach`s alphas and average variance extracted between factors. The Copenhagen Burnout Inventory I was statistically and positively correlated with depression, anxiety and stress symptoms, as well as rumination, and negatively correlated with life satisfaction.Discussion: The current study shows that the Copenhagen Burnout Inventory is a psychometrically valid measure of burnout in Portuguese physicians, and contributes with an instrument able to produce a global index of burnout. This measure provides comprehensive information on different dimensions associated with the development of burnout, as well as presents a global burnout score. Results show that participants who had more burnout also presented higher levels of depressive, anxiety and stress symptoms, as well as present more ruminative thinking, and less life satisfaction.Conclusion: The Copenhagen Burnout Inventory is a psychometrically valid measure of burnout that allows for exploratory studies on the overall level of exhaustion, thus making it possible the comparison between groups in a way that is not restricted to occupation specific aspects.
Tendências Epidemiológicas das Fraturas do Fémur Proximal na População Idosa em Portugal
Authors: Silva João , Linhares Daniela , Ferreira Mariana , Amorim Nélson , Neves Nuno , Pinto Rui 
Published: October 2018

Introdução: As fraturas do fémur proximal representam um problema de saúde pública nas sociedades industrializadas. São escassos os estudos sobre a incidência destas fraturas em Portugal. O objectivo deste estudo foi analisar e interpretar as tendências epidemiológicas das fraturas do fémur proximal, na população idosa em Portugal, no período de 2005 a 2013.Material e Métodos: Estudo transversal incluindo todos os doentes com idade igual ou superior a 65 anos admitidos por fratura do fémur proximal em hospitais portugueses pertencentes ao serviço nacional de saúde com recurso aos dados do registo nacional da administração central do sistema de saúde.Resultados: Foram incluídos 101 436 doentes. Observou-se um aumento progressivo no número de internamentos por ano ao longo do período analisado. A idade média à admissão foi de 79,32 (± 12.33) anos apresentando um aumento progressivo e significativo ao longo do período analisado (p < 0,001). Dos doentes, 74.5% eram do sexo feminino (p < 0,001). Apresentavam idade média à admissão significativamente superior, quer globalmente, quer em cada ano em estudo (p < 0,001). A incidência ajustada à idade (≥ 65 anos) foi de 597 fraturas / ano / 100 000 habitantes. Verificou-se um aumento na incidência de fraturas do fémur proximal de 508,49 (2005) para 628,39 fraturas por 100 000 pessoas / ano (2013). No sexo feminino o aumento foi de 616,78 para 762,88 e no masculino de 339,95 para 419,06.Discussão: Este é o primeiro estudo a avaliar e interpretar as tendências epidemiológicas das fraturas do fémur proximal em doentes admitidos nos hospitais do Serviço Nacional de Saúde em Portugal incluindo apenas indivíduos com idade igual ou superior a 65 anos.Conclusão: O número absoluto de fraturas do fémur proximal em Portugal mostrou uma tendência de aumento entre 2005 - 2013, afetando uma percentagem significativa da população portuguesa com mais de 65 anos de idade. Tendem a ocorrer mais comummente no sexo feminino e em indivíduos progressivamente mais velhos.
Case Report: Medical Aspect, Growth, and Quality of Life in Children with 46,XX Testicular Disorder of Sex Development (DSD)
Authors: Rochmah Nur , Faizi Muhammad , Andriani Irwina Rahma , Pasulu Soraya Salle 
Published: October 2018

46,XX testicular disorder of sexual development (DSD) is characterized by male phenotype with 46,XX karyotype. The incidence rate is 1:25,000 in male newborn. Infants with ambiguous external genitals will be confronted with issue of gender assigment and may result in a stressful condition in the parents. Since gender assignment is inevitable, several factors should be considered in DSD management. The management approach for children born with DSD is individualized and multidisciplinary. Gender assignment aims to facilitate the patient to obtain the best quality of life. Adaptation of children with 46,XX testicular DSD as a determinant of quality of life is also influenced by psychological and family conditions. The purpose of this report was to observe medical growth and development aspects of the child with 46,XX terticular DSD as indicated by the aspects of growth and development, and health related quality of life, as well as the influential aspects. PA, 18 months, was diagnosed with 46,XX testicular DSD. The patient routinely visited to endocrinology clinic, urologic surgery, and child psychiatry clinic from the age of 6 months. The parents decided to raise patient as male. The patient had undergone surgery for hypospadias correction, hormone injections, child growth monitoring, and psychological monitoring (medical records of Dr. Soetomo Hospital, Surabaya in 2015). Management should consider individual and multidiciplinary accompaniment of the patient and parents, the importance of group support, and follow-up to adulthood, as well as possible longterm outcomes that will occur in the future so that the patients and the parents need to be prepared.
Performance of silver-coated red soil nanocomposites in water disinfection
Authors: Mahmoudi Ebrahim , Moeinpour Farid 
Published: October 2018

Abstract
The present research studied the anti-bacterial effect of silver-coated red soil nanoparticles on Gram-negative bacteria Escherichia coli (E. coli) from water. The effects of disinfectant concentration (0.02, 0.05 and 0.1 g/mL), contact time (10, 20 and 30 minutes) and bacteria number (102, 104 and 106 CFU/mL) have been also investigated. To obtain important factors, the interactions between factors and optimal experimental design in surface response method were used based on Box-Behnken design. According to the research findings, the system is efficient in eliminating E. coli. The results showed that E. coli elimination efficiency intensified through increasing the amount of disinfectant from 0.02 to 0.1 g/mL. Expanding contact time from 10 minutes to 30 minutes also heightened the E. coli elimination rate. R2 for E. coli elimination is 0.9956 indicating a good agreement between model experimental data and forecasting data.
Pharmacological Management of Chronic Obstructive Lung Disease (COPD). Evidence from a Real-World Perspective - Part 2
Authors: Kisialiou Aliaksei , Prinzi Giulia , Lamonaca Palma , Cardaci Vittorio , Tomino Carlo , Fini Massimo , Bonassi Stefano , Russo Patrizia 
Published: October 2018

Background:
We report a comprehensive overview of current COPD therapies from a
real-world experience.

Objective:
Critically review the opportunities and the challenges occurring in the real-world treatment
of COPD.

Methods:
This is a review that also report results from COPD patients treated with standardized
therapy including pulmonary rehabilitation (Real World Data – RWD).

Conclusion:
Comprehensive assessment of COPD management requires strategies able to evaluate
efficacy and usefulness in a real-world population, that take into account the interaction between
experience and academic training, research, adherence to guidelines and judgments in order to plan
the appropriate and optimum use of available strategies.
Rho-kinase (ROCK) Inhibitors - A Neuroprotective Therapeutic Paradigm with a Focus on Ocular Utility
Authors: Abbhi Vasudha , Piplani Poonam 
Published: October 2018

Background:
Glaucoma is a progressive optic neuropathy causing visual impairment
and Retinal Ganglionic Cells (RGCs) death gradually posing a need for neuroprotective
strategies to minimize the loss of RGCs and visual field. It is recognized as a multifactorial
disease, Intraocular Pressure (IOP) being the foremost risk factor. ROCK inhibitors have been
probed for various possible indications, such as myocardial ischemia, hypertension, kidney
diseases. Their role in neuroprotection and neuronal regeneration has been suggested to be of
value in the treatment of neurological diseases, like spinal-cord injury, Alzheimer’s disease
and multiple sclerosis but recently Rho-associated Kinase inhibitors have been recognized as
potential antiglaucoma agents.

Evidence Synthesis:
Rho-Kinase is a serine/threonine kinase with a kinase domain which is
constitutively active and is involved in the regulation of smooth muscle contraction and stress
fibre formation. Two isoforms of Rho-Kinase, ROCK-I (ROCK β) and ROCK-II (ROCK α)
have been identified. ROCK II plays a pathophysiological role in glaucoma and hence the inhibitors
of ROCK may be beneficial to ameliorate the vision loss. These inhibitors decrease
the intraocular pressure in the glaucomatous eye by increasing the aqueous humour outflow
through the trabecular meshwork pathway. They also act as anti-scarring agents and hence
prevent post-operative scarring after the glaucoma filtration surgery. Their major role involves
axon regeneration by increasing the optic nerve blood flow which may be useful in
treating the damaged optic neurons. These drugs act directly on the neurons in the central visual
pathway, interrupting the RGC apoptosis and therefore serve as a novel pharmacological
approach for glaucoma neuroprotection.

Conclusion:
Based on the results of high-throughput screening, several Rho kinase inhibitors
have been designed and developed comprising of diverse scaffolds exhibiting Rho kinase inhibitory
activity from micromolar to subnanomolar ranges. This diversity in the scaffolds with
inhibitory potential against the kinase and their SAR development will be intricated in the
present review. Ripasudil is the only Rho kinase inhibitor marketed to date for the treatment
of glaucoma. Another ROCK inhibitor AR-13324 has recently passed the clinical trials
whereas AMA0076, K115, PG324, Y39983 and RKI-983 are still under trials. In view of this,
a detailed and updated account of ROCK II inhibitors as the next generation therapeutic
agents for glaucoma will be discussed in this review.
Nutraceuticals and Diet-based Phytochemicals in Type 2 Diabetes Mellitus: From Whole Food to Components with Defined Roles and Mechanisms
Authors: Onaolapo Adejoke Yetunde , Onaolapo Olakunle James 
Published: October 2018

Background:Over the past decades, the development and use of an array of prescription medications have considerably improved the clinical management of type 2 diabetes mellitus and the quality of life of patients. However, as our knowledge of the associated risk factors and approaches to its management increases, the increasing roles of diet and the composition of the diet in the etiology and successful management of diabetes mellitus are being illuminated. Presently, a lot of attention is being given to nutraceuticals and certain phytochemicals that are integral parts of the human diet. It is believed that a clearer understanding of their roles may be crucial to ‘non-invasive’ or minimallyintrusive management, with regards to daily living of patients. In this review, an overview of nutraceutical components and phytochemicals that may be of benefit, or had been known to be beneficial in diabetes mellitus is given. Also, how the roles of such dietary components are evolving in the management of this disorder is highlighted. Lastly, the obstacles that need to be overcome before nutraceuticals can be considered as options for the clinical management of diabetes mellitus areconsidered.Conclusion:Despite studies that demonstrate their efficacy, no nutraceutical or food-derived compound has been formally adopted as a direct replacement for any class of antidiabetic drugs.
3D-QSAR and Molecular Docking Studies on Design Anti-Prostate Cancer Curcumin Analogues
Authors: Meng Xi , Cui Lianhua , Song Fucheng , Luan Mingyuan , Ji Junjie , Si Hongzong , Duan Yunbo , Zhai Honglin 
Published: October 2018

Background:Prostate cancer is one of the most common tumors in the world and the fifth leading cause of male cancer death. Although the treatment of localized androgen-dependent prostate cancer has been successful, the efficacy of androgen-independent metastatic disease is limited. Curcumin, a natural product, has been found to inhibit the proliferation of prostate cancer cells.Objective:To design curcumin analogs with higher biological activity and lower toxicity and side effects for the treatment of prostate cancer.Methods:In this study, the three dimensional-quantitative structure activity relationship (3DQSAR) and molecular docking studies were performed on 34 curcumin analogs as anti-prostate cancer compounds. We introduced OSIRIS Property Explorer to predict drug-related properties of newly designed compounds.Results:The optimum CoMSIA model exhibited statistically significant results: the cross-validated correlation coefficient q2 is 0.540 and non-cross-validated R2 value is 0.984. The external predictive correlation coefficient Rext 2 is 0.792. The information of structure-activity relationship can be obtained from the CoMSIA contour maps. In addition, the molecular docking study of the compounds for 3ZK6 as the protein target revealed important interactions between active compounds and amino acids.Conclusion:Compound 28i may be a new type of anti-prostate cancer drug with higher biological activity and more promising development.
MALDI MS Analysis to Investigate the Lipid Composition of Sperm
Authors: Engel Kathrin M. , Jakop Ulrike , Müller Karin , Grunewald Sonja , Paasch Uwe , Schiller Jürgen 
Published: October 2018

Background:
The sperm plasma membrane meets the requirements of sperm transit
through the female genital tract and subsequent fertilization. Commonly, the (phospho)lipid composition
of sperm is characterized by tremendous amounts of highly unsaturated fatty acyl residues such
as docosahexaenoic and docosapentaenoic acid. While human sperm contain almost exclusively diacyl
lipids, many animal sperm additionally contain significant amounts of ether lipids such as alkylacyl-
and alkenyl-acyl lipids (plasmalogens).

Hypothesis/Objective:
It is suggested that deviations from the typical lipid composition are indicative
of pathological changes. Therefore, simple methods to elucidate the sperm lipid composition are essential.

Method:
Matrix-assisted laser desorption and ionization (MALDI) mass spectrometry (MS) is a fast
and simple method. Since the selection of the most suitable matrix is a crucial step in MALDI MS,
this topic will be highlighted. It will also be shown that MALDI MS can be easily combined with
thin-layer chromatography to overcome ion suppression effects.

Results:
The lipid composition of sperm from different species can be elucidated by MALDI MS.
However, different matrix compounds have to be used to record positive and negative ion mass spectra.
Since some sperm (glyco)lipids are characterized by the presence of sulfate residues which suppress
the detection of less acidic lipids in the negative ion mode, previous separation is often necessary.
It will be also emphasized that plasmalogens can be easily identified by either enzymatic digestion
or treatment with acids.

Conclusion:
MALDI MS is a reliable method to obtain sperm lipid fingerprints in a simple and convenient
way.
An Overview of EEG Seizure Detection Units and Identifying their Complexity- A Review
Authors: Rajendran T. , Sridhar K.P. 
Published: October 2018

Objective:
In everyday life, more and more people suffer from various diseases. To prefer
the best medicine for them, an exact diagnosis is to be done. For example, the Epilepsy patients
encounter many challenges because they must take precautionary measures to protect themselves
from injury during a sudden occurrence of seizures.

Materials and Methods:
The investigations of epilepsy can be made analysing Electroencephalogram
(EEG) motions to break down the conduct of the cerebrum amid seizures. To find the exact
seizure frame in EEG signal is difficult and the overall analysis results is tedious in terms of human
error.

Results:
Hence, there is a need for automatic detection, exact prediction, and classification of
EEG waves. Similarly, another potential utilization of EEG signal investigation is in the prediction
of epileptic seizures before they occur. This step relieves the patients of anxiety and empowers
their guardians.

Conclusion:
In this study, we first concentrated on seizure discovery and classification issue. Secondly,
some bits of knowledge on the complications involved in seizure-management are mentioned.
Finally, some suggestions are listed with seizure classifications.
How Does Plasma Activated Media Treatment Differ From Direct Cold Plasma Treatment?
Authors: Attri Pankaj , Park Ji Hoon , Ali Anser , Choi Eun Ha 
Published: October 2018

Objective: The aim of the paper is to investigate the optimum condition for generation of Plasma
Activated Media (PAM), where it can deactivate the cancer cells while minimum damage for normal cells.
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Background: Over past few years, cold atmospheric Plasma-Activated Media (PAM) have shown its promising
application in plasma medicine for treatment of cancer. PAM has a tremendous ability for selective anti-cancer
capacity in vitro and in vivo.

Methods:
We have analyzed the radicals in air using the optical emission spectroscopy and in culture media
using chemical analysis. Further, we have tested the toxicity of PAM using MTT assay.

Results:
We observed that more cancer cell death is for the Ar plasma followed by the Ar-N2 plasma, and the
least cell death was observed for the Ar-O2 plasma at all treatment times both by direct treatment and through
PAM treatment. The concentration of the RNS species is high for Ar-N2 plasma in gas as well as inside the
culture media compared to that for pure Ar plasma. However, the difference is significantly less between the Ar
plasma treatments and the Ar-N2 plasma treatments, showing that ROS is the main factor contributing to cell
death.

Conclusion:
Among all three feeding gas plasmas the best system is Ar-O2 plasma for direct treatments towards
the cancer cells. In addition, the best system for PAM preparation is Ar-N2 at low time treatments (1 min and 2
min) because it has no effect on normal cells, but kills the cancer cells.