bluuebunny/crossref_metadata_2025_split huggingface dataset:
The role of tourniquet in myomectomy: an observational study
Authors: Sanyal Urmi , Ghosh Shilpa , P. B. Hiremath , Hiremath Reshma 
Published: March 2019

Background: Leimymoma is one of the commonest benign tumours encountered in women during the reproductive age. One quarter of these women may be symptomatic. When surgical management is indicated, myomectomy may be considered as the procedure of choice. Myomectomy can be complicated by severe intraoperative haemorrhage. One of the methods to reduce blood loss during myomectomy is the mechanical application of tourniquet.Methods: A prospective observational single arm study was done with 24 women who underwent open myomectomy to determine the utility of tourniquet in reducing blood loss during the procedure. Women of reproductive age group, having symptomatic fibroid, not responding to medical therapy, not completed their family and with total uterine size not exceeding 20 weeks were included in the study while those with pregnancy, concomitant adenomyosis, cervical or broad ligament fibroid, bleeding diathesis were excluded. The 7-French pediatric feeding tube was used as tourniquet. Our primary end point was intra-operative blood loss. Secondary outcome measures included operative morbidity and blood transfusion rates.Results: It was seen that application of the tourniquet considerably reduced the amount of blood loss and made resection of the myoma much easier. 83.3% patients had a blood loss less than 200ml and the rest between 200ml and 400ml. For majority of the patients (75%) the postoperative change of PCV was between 1 and 2%.Conclusions: The infant feeding tube form of tourniquet is cheap, safe, readily available, effectively reduces blood loss during myomectomy while not adding to the complications due to the operation.
HELLP syndrome, a difficult diagnosis: a case report
Authors: Pradhan Shweta , Bhattacharjee Somen 
Published: March 2019

HELLP is an acronym that refers to a syndrome characterized by Haemolysis with a microangiopathic blood smear, Elevated Liver enzymes, and a Low Platelet count. Recent studies suggested that some women will develop HELLP without the manifestations of classical symptoms. Authors present the case of a 22-year-old normotensive primigravida who went into severe thrombocytopenia and haemolysis leading to DIC, finally the diagnosis of normotensive HELLP syndrome was made. Present case report attempts to illustrate the diagnostic dilemma that a clinician faces in diagnosing an atypical presentation of HELLP syndrome. Management of jaundice during pregnancy especially in third trimester remains a dilemma for the obstetrician because of its varied aetiology, unpredictable prognosis and guarded perinatal outcome. Authors therefore recommend a rational stepwise approach toward the diagnosis of HELLP syndrome and its atypical presentation.
Extramedullary hematopoiesis in ovary: a rare presentation of CML
Authors: Agarwal Akriti , Gokhale Asha Niranjan 
Published: March 2019

Extramedullary hematopoiesis (EMH) is a rare phenomenon, and represents infiltration and proliferation of myeloid, erythroid, and megakaryocytic cells in non-bone marrow sites. Extramedullary hematopoiesis (EMH) is normal during fetal life, but after birth, the presence of EMH is considered to be abnormal. EMH has been associated with CML (chronic myeloid leukaemia). Lymph node is the most common site of involvement, other sites being the abdomen (liver, spleen) and thorax (bone, mediastinum) but very rarely in the gynecological tract. Here authors report a case of a 20-year young female, a known case of CML who presented with abdominal pain with hemoperitonium, with negative urine pregnancy test. Initially hemorrhagic corpus luteal cyst was thought to be the cause of hemoperitonium and patient was taken for surgery wherein histopathology confirmed the diagnosis of extra medullary hematopoiesis of ovary. Women with CML when presents with hemoperitoneum, extramedullary hematopoiesis should be a differential diagnosis apart from rupture ectopic and other causes of spontaneous hemoperitoneum. Patient was started on imatinib after diagnosis and is doing well.
A clinical study on the presentation and management of liver abscess in eastern Uttar Pradesh and evaluation of a low cost technique of percutaneous catheter drainage
Authors: Kumar Gupta Amit , Kumar Yogesh , Soni Annanya 
Published: March 2019

Background: The objective of the study was to assess the outcome of various modalities of treatment and evaluation of a low cost technique of percutaneous catheter drainage of liver abscess.Methods: A prospective study of patients with liver abscess was conducted in a tertiary care centre over a period of one year. Since the cost of commercially available catheter (pig tail type) for image guided percutaneous drainage of liver abscess is quite high (approx Rs 800) and considering the fact that a considerable population in eastern Uttar Pradesh is poverty stricken, this study includes an evaluation of low cost technique of percutaneous drainage of liver abscess as a pilot project. In the present study K-90 was used as “low cost drainage” and compared with pig tail catheter drainage.Results: Total 34 patients with liver abscess were enrolled in the study. 31 cases were male and 3 cases were female. 34 cases were subjected to catheter drainage (pig tail catheter, K-90) yielding varying quantities of pus from 300 ml to 2200 ml, depending on the size of the abscess. 15 out of 34 patients underwent tube drainage (K-90) by our innovative trochar cannula system using 5 mm laparoscopic metal trochar.Conclusions: Although, compared to pig tail drainage, K-90 tube drainage is associated with more number of minor complication and prolonged hospital stay, however looking to the advantages and greatly reduced cost its use is probably justified.
Polymorphic locus rs652438 of the MMP12 gene is associated with the development of hypertension in women
Authors: Moskalenko M. I. , Ponomarenko I. V. , Polonikov A. V. , Churnosov M. I. 
Published: March 2019

Objective.To study the association of polymorphic loci rs243865 MMP2, rs17577 MMP9, rs652438 MMP12 with the development of arterial hypertension (HTN) in women of the Central Chernozem Region of Russia.Design and methods.A total of 584 women were examined: 375 HTN patients and 209 controls. Analysis of the polymorphic loci of metallоproteinases was performed using real-time polymerase-chain reaction (PСR). Statistical analysis was carried оut using software “STATISTICA for Windows 10.0”. The prediсtive value of the non-synоnymous single nucleotide polymorphism (SNP) wаs estimatеd using the Sorting Tolerant From Intоlerant software (http://sift.jcvi.org/). The regulatorу potential of polymоrphic loci was analyzеd in the HaplоReg software (v4.1) (http://archive.brоаdinstitute.оrg). The effect of SNP on gene expression was studied using thе data of the Genоtype-Tissue Expressiоn project (http://www.gtexportal.оrg/).Results.We found an association of the locus rs652438 MMP12 with the occurrence of HTN in women. Polymorphic variant G (odds ratio (OR) = 1,86, 95 % confdence interval (CI) = 1,02–3,45, p = 0,04) and genotype GA (OR = 2,04, 95 % CI = 1,06–3,98, p = 0,03) of rs652438 are associated with the high risk of HTN development. The genotype AA rs652438 demonstrates a protective effect regarding the risk of HTN occurrence (OR = 0,50, 95% CI = 0,26–0,95, p = 0,03). We assume that the epigenetic effects of rs652438 MMP12 underlie the identifed associations. The locus rs652438 MMP12 is nsSNP and has a SIFT Score = 0,01. This polymоrphism is lоcated in histоnes regiоn marking prоmoters (H3K9 ас) and enhаncers (H3K4me1, H3K27 ас). The locus is in linkage disequilibrium (r 2 = 0,95) with SNP that affect the expression level of the MMP12 gene
The Effect of Assertiveness Psychoeducation Program on Increasing the Assertiveness of University Students
Authors: PARMAKSIZ İzzet 
Published: March 2019

This study examined whether or not the
psychoeducation program, which was revised by field experts for university
students with low assertiveness level, increased participants’
assertiveness. The study was designed
using pretest, posttest and follow-up test. In order to compare the effect of
the program, the study employed the experimental model in which a control group
was formed. The study group consisted of a total of 16 students who were
attending a university’s vocational school in Central Anatolia during the
academic year of 2017-2018. There were eight students in the experimental group,
and eight in the control group. The participants were selected on a volunteer
basis. Developed by Voltan-Acar and Öğretmen (2007) to measure the
assertiveness levels of university students, Voltan-Acar Assertiveness
Inventory was used to collect the study data. The difference between the
assertiveness levels of the participants in the experimental and control group
was examined. Mann-Whitney U-test was
used for different groups to analyze the differences between groups. Wilcoxon
signed ranks test was employed to analyze the change within the same group. At
the end of the study, there was a significant increase in the assertiveness
levels of the participants in the psychoeducation program. This training will
contribute to theoretical and practical studies and to field experts in the
field of assertiveness and social skills acquisition. It will also encourage
future studies on assertiveness.
Genetic background of Meniere’s disease
Authors: Szyfter Krzysztof , Gawęcki Wojciech , Szyfter Witold 
Published: March 2019

Meniere’s disease (MD) as an inner ear disorder including such symptoms as recurrent vertigo attacks, tinnitus, fluctuating or progressive sensorineural hearing loss. Its relatively frequent familial incidence implicates a genetic background. An autosomal dominant inheritance was commonly observed with a few exceptions. It was established that Meniere’s disease is not a monogenic disorder. Instead a group of genes of genomic and mitochondrial genes was established as determinants of hearing loss. Another group of genes was associated with inner ear (vestibulum, labyrinth, endolymph) alterations followed by dizziness and tinnitus. Altogether, many studies suggest a multigenic interaction to predispose to develop Meniere’s disease.
The characteristic of dietary supplementation among elderly women
Authors: Wojciak Rafal Wojciech , Cisek-Woźniak Angelika , Tomczak Ewa 
Published: March 2019

Aim. There is a growing awareness in Polish society, that a healthy lifestyle and proper nutrition have positively affected in old age. This effect influences the increasing consumption of dietary supplements to improve the health, however sometimes in an uncontrolled way. Taking above together the aim of this preliminary study was to assess the prevalence of the use of dietary supplements in elderly women.Material and Methods. The study was conducted on 95 elderly women aged 65 to 89 years. The participants were asked to complete a questionnaire about their physical activity as well as medicines and supplements intake.Results. Based on the questionnaire, it can be concluded that supplementation was common among the tested group. The most frequently seniors used preparations to assist the circulatory system and diet supplements. They also took this, supporting the work of the intestine, to assist urinary tract and the work of heart. The decision to start of supplementation was most often taken under the influence of television advertisements, pharmacy worker as well as from friends. There were statistically differences in presented results between studying populations according to their age. Conclusions. Important and essential is education of older people, concerning the appropriate use of dietary supplements, to make supplementation safe and distinct improvement in health.
Mass spectrometry analysis of redox forms of High-Mobility Group Box-1 Protein in cerebrospinal fluid: initial experience.
Authors: Światły Agata , Wąsik Norbert , Hajduk Joanna , Matuszewska Eliza , Dereziński Paweł , Sokół Bartosz , Jankowski Roman , Kokot Zenon , Matysiak Jan 
Published: March 2019

Introduction. High-mobility group box 1 (HMGB1) is an alarmin with proinflammatory potential determined by redox status of the cysteines at position 23 and 45. It may also play a role as a biomarker in biological fluids. The aim of this study was the identification of different HMGB1 redox forms in cerebrospinal fluid (CSF) obtained from subarachnoid hemorrhage patients.
Material and Methods. 6 CSF samples were collected from aneurysmal subarachnoid haemorrhage patients. Commercially available HMGB1 isoforms served as a positive control. Immunoprecipitation and electrophoretic isolation of HMGB1 protein were performed, then both CSF and control were analyzed using mass spectrometry technique. To distinguish between fully reduced (thiol group at C23 and C45) and disulfide (disulfide bond connecting C23 and C45) HMGB1 forms, top-down sequencing of the spectra was performed.
Results. Top-down sequencing analysis allowed to distinguish between HMGB1 isoforms only in commercially available standard without preceding immunoprecipitation and electrophoresis. MALDI spectra differ i.e. on the fully reduced HMGB1 spectrum fragmentation occurs before and beyond C22, which is not present on the disulfide HMGB1 spectrum. Analysis of HMGB1 isolated from CSF obtained from subarachnoid hemorrhage patients gave no results.
Conclusions. Top-down sequencing enables to distinguish between redox forms of HMGB1. Electrophoresis and tryptic digestion cannot precede mass spectrometry analysis of redox forms of HMGB1 due to the reduction of disulfide bonds during these processes. Preferred method of isolation of HMGB1 for direct analysis using top-down sequencing mustn’t include protein digestion or degradation.
Force decay of intermaxillary orthodontic elastics: in vitro study
Authors: Kardach Hubert , Olszewska Aneta , Firlej Ewa , Bogdanowicz Agnieszka , Golusińska-Kardach Ewelina , Szponar-Żurowska Anna , Biedziak Barbara 
Published: March 2019

Introduction. Orthodontic elastics are widely used in orthodontic treatment. It’s been proved that they have advantages such as low cost, ease of use, but also disadvantages, mainly force decay in time and increased entrapment of biofilm. Amount of the force is of extreme significance. This force can be altered by physical or chemical factors. Material and Methods. Latex elastics in 3 different diameters were selected for this study. Each elastic was stretched and placed on hooks that are at specified distances that equal 3 times the diameter of each elastic. The forces produced by stretching was measured using tension gauge and the measurement were taken at specific time intervals of 0h, 3h, 12h, 24h. The same process was repeated for elastics in dry and artificial environment. Results. Elastics in the dry environment showed progressive force decay cause by stretching over time. Just after 3 hours force decay between 6,07% and 8,75% was observed. The biggest loss of force between 13,61 — 16,13 % was measured after 24 hours. Compared to the dry environment, an even more significant force decay was observed in the artificial saliva. After first 3 hours force loss was between 4,99% — 9,22%. The biggest force decay was observed after 24 hours and it was 5 % higher compared to dry environment. Conclusions. 1) The artificial saliva environment and time of exposure to it, have a negative effect on the properties of elastomeric. 2) To maintain the effective orthodontic strength of elastics, they should be replaced every 12 hours.
Skin necrosis after SUPERknee procedure – typical versus modified surgical approach
Authors: Shadi Milud , Janusz Piotr , Koczewski Paweł , Walczak Michał , Kraśny Joanna , Kotwicki Tomasz 
Published: March 2019

Introduction. SUPERknee procedure (SK) is a treatment for complex knee instability in children with congenital deformations. Due to wide surgical approach and long time of surgery (ST) the skin around the knee is in risk of ischemic necrosis (SN) or healing complications (HC). Aim. The purpose of the study is to compare incidence of SN in SK using typical and modified approach.Material and Methods. Sixteen patients underwent SK since 2015 till 2016, in mean age 8.1 (4.3–12.7) y.o. In 8 cases SK and in 8 SK combined with SUPERhip (SK+SH) was performed. In 6 patients (3 SK and 3 SK+SH) the approach was performed from one incision (OIA). In 10 patients (5 SK and 5 SK+SH) a modified approach was performed, involving additional skin incision (DIA). The occurrence of SN, ST and risk factors of HC were evaluated. Results. SN appeared in 2 cases treated with OIA (33%). There was no SN in DIA (0%). With this number of patients the difference was below level of significance, p = 0.1250, OR = 11.7. In one patient treated with SK+SH area of SN was 17.5 cm2. In the other patient treated with SK 35 cm2. Mean ST in SK was 3.4h (2.5–4.0) and in SK+SH 4.6h (4.0–5.5). ST of the surgery with OIA was 4.1h (2.5–5.5) and in DIA 3.7h (3.0–4.5), p = 0.4746. No additional risk factor relevant to SN was found.
Keywords: SUPERknee, SUPERhip, super knee, super hip, healing complications, skin necrosis.
A thousand words about the cardiopulmonary exercise test in respiratory system diseases
Authors: Tarchalski Jacek , Piorunek Tomasz , Guzik Przemysław 
Published: March 2019

The cardiopulmonary exercise test (CPET) is designed to measure some physiological variables related to the function of the cardiovascular and respiratory systems during exercise. Usually, the CPET is performed either on a treadmill or a cycle ergometer. In this mini‑review, we describe a set of parameters which are most commonly used to quantify CPET. We also summarize clinical indications for this test and interpretation of the obtained results in patients with respiratory system diseases. The CPET, if made appropriately, may deliver valuable information helpful in the diagnosis, e.g., of unexplained dyspnea, and prognosis, e.g., in chronic obturatory pulmonary disease, pulmonary hypertension, or interstitial lung diseases.
A Geomechanics-Coupled Embedded Discrete Fracture Model and its Application in Geothermal Reservoir Simulation
Authors: Yu Xiangyu , Winterfeld Philip , Wang Shihao , Wang Cong , Wang Lei , Wu Yu-shu 
Published: March 2019

Abstract
Geomechanics plays an essential role in fluid/heat flow by affecting hydraulic parameters. This influence could be amplified when fractures exist in the system because fracture aperture is highly sensitive to stresses. Coupled fluid/heat flow and geomechanics model is considerably important in simulating thermal-hydrologic-mechanical process, such as geothermal reservoir development. At the same time, due to the rock matrix shrinkage or expansion, thermal stress exerted on fracture surface remolds the aperture significantly and should be incorporated in modeling heat related process.
In this study, a coupled fluid/heat flow and geomechanics model, TOUGH2-THM, was developed based on the parallel framework of TOUGH2-CSM, with stress tensor components as primary variables. This modification is aiming on computing normal stresses on discrete fracture surface such that fracture related parameters can be fully coupled with geomechanical model. Embedded discrete fracture model was also improved to be compatible with the geomechanical coupling. Both of TOUGH2-THM and modified EDFM were validated for further application.
A geothermal reservoir simulation is conducted by the newly developed model, demonstrating the capability of this program to perform coupled modeling. It is also concluded that geomechanics and especially temperature alteration induced stress could affect fluid/heat flow in fracture and rock matrix. Thus, production efficiency could be impacted as well. The thermal stress generated by temperature reduction could enhance the fracture permeability in orders of magnitude. Various scenarios of injection temperature were modeled and compared. It can be observed that geothermal reservoir development is negatively influenced by geomechanical (and thermal) effect on fractures. The coupled model is helpful to improve the simulation accuracy.
Salt, Cold, and Drought Stress on Einkorn and Bread Wheat during Germination
Authors: ZENCİRCİ Nusret , ULUKAN Hakan , ORDU Bülent , ASLAN Didem , MUTLU Hakan Tahiri , ÖRGEÇ Mehmet 
Published: March 2019

Climate
changes prompt salt, cold, and drought stresses especially during early crop
growth stages. The damages during germination in wheat may even destroy whole
crop. Here, 12 bread and 10 einkorn wheats entries were distressed under salt,
cold and drought. Germination rate and
germination power, coleoptile, shoot length, root length, shoot to root length
ratio, root fresh and dry weight and root fresh to dry weight ratio were
quantified under six salt, cold, drought stresses and one control. After ANOVA
and LSD discriminated the entries, stress tolerance indices differentiated six
tolerant and six susceptible entries. MANOVA, Pillai’s Trace and Wilks’ Lambda
tests finalized the stress testing. Shoot and root length, root fresh and dry
weight highly differed under salt, cold and drought. Bayraktar-2000 well
tolerated salt, drought, salt-drought and salt-cold-drought; Gerek-79 salt,
salt-drought, salt-cold-drought; Momtchil salt, cold and salt-cold-drought;
İkizce-96 salt, drought and salt-drought. Einkorn Population 14 was susceptible
to all stresses except cold and salt-cold; Population 15 to salt, salt-drought
and salt-cold-drought; Population 11 to salt, drought, salt-drought and salt-cold-drought.
These stresses sharply decreased shoot and root length, root fresh and root dry
weight. The higher % decreases under salt, cold and drought were in shoot
(59.72, 63.25 and 23.17) and root length (32.91, 51.77 and 34.69), root fresh
(44.32, 49.11 and 38.88) and root dry weight (21.63, 42.14 and 41.97).
Moreover, Pillai’s trace and Wilks’ Lambda tests differentiated both characters
and entries (P &lt; 0.01). In conclusion, Momtchil, Gerek-79, Bayraktar-2000,
Populations 5, 6, and 1 are well endorsed against triple seedling stresses.
Stage-discharge estimation in compound open channels with composite roughness
Authors: Kavousizadeh Amirreza , Maghrebi Mahmoud F. , Ahmadi Arash 
Published: March 2019

Abstract
Determination of stage-discharge relationships in natural rivers is extremely important in flood control projects. The importance of rating curves in rivers and the difficulty of its establishment show the need for simpler and more precise methods. Determination of rating curves in compound channels, especially with composite roughness, has proved to be difficult because of significant variations in hydraulic parameters from the main channel to the floodplains. In the current paper, a new approach that is based on the concept of the cross-sectional isovel contours is introduced for estimation of the stage-discharge curves in compound channels. The multivariate Newton's method is applied to the difference between the observed and estimated data to optimize the exponent values of the governing parameters. The proposed method is verified by comparing predictions obtained by using it with some experimental datasets. For compound channels with composite roughness, the stage-discharge curves obtained by the proposed method are more accurate than those obtained by using available conventional methods.