bluuebunny/crossref_metadata_2025_split huggingface dataset:
Enrichments of Metals, Including Methylmercury, in Sewage Spills in South Carolina, USA
Authors: Emmons Alison M. , Bizimis Michael , Lang Susan Q. , Stangler William , Geidel Gwendelyn , Baalousha Mohammed , Wanamaker Emma , Rothenberg Sarah E. 
Published: July 2018

Exposure to microbial pathogens is the primary concern of sanitary sewer overflows; however, sewage spills may also be a significant source of toxic metals, including methylmercury (MeHg). Between November 2015 and January 2017, after Hurricane Joaquin, surface water samples were collected routinely from three creeks in Columbia, SC. Routine sampling coincided with six sewage spills. Total mercury (THg) and MeHg (unfiltered and filtered) and 32 other metals (filtered) were measured. Compared with surface water samples, THg (unfiltered and filtered), MeHg (unfiltered), and 19 other metals were significantly higher in sewage spills (all log10–transformed) (two‐tailed t test, p < 0.05 for all, n = 38–42). Toxic weighting factors were applied to 18 metals, including THg and MeHg, in samples collected directly from sewage spills (n = 3–4) and a wastewater outfall (n = 5). On average, sewage was 18.2 and 12.0 times more toxic for THg and MeHg, respectively, and 1.75 times more toxic for all 18 metals, compared to treated effluent from the wastewater outfall. Results suggest sewage spills were a source of inorganic Hg, MeHg, and other metals to the receiving waters and may potentially contribute to water quality impairments.Core Ideas
Sewage spills were a significant source of methylmercury (MeHg) to surface waters.
Sewage spills were a significant source of 19 (of 32) other metals, including copper.
Sewage was 1.75 times more toxic for 18 metals than treated wastewater.
Receiving waters are impaired due to copper and fish tissue MeHg.
Frequent sewage spills may contribute to water quality impairments.
Soil Phosphatase Activities across a Liming Gradient under Long‐Term Managements in Kenya
Authors: Margenot Andrew J. , Sommer Rolf , Parikh Sanjai J. 
Published: July 2018

Core Ideas
We investigated liming in soil mesocosms from 11‐yr managements: no input, mineral N+P, and manure.
There were minor or no changes in labile inorganic P, labile organic P, and microbial biomass P.
Changes in the activity of different phosphatases following liming depended on management.
Liming decreased acid phosphomonoesterase/phosphodiesterase across management systems.
Liming can impact the enzymatic component of soil P cycling in the short term.
Changes in the biological drivers of soil P cycling could contribute to improving P availability in weathered soils after liming. The effect of liming on P cycling was evaluated for a Rhodic Kandiudox in western Kenya under no fertilization (UNF), mineral N + P (MIN), and manure (ORG). Ca(OH)2 was applied at six rates in soil mesocosms to establish a pH gradient (4.7–6.4). Labile inorganic P (Pi) increased by ≤1.2 μg g–1 in response to lime and labile organic P (Po) was weakly affected. In MIN, microbial biomass P (Pmic) decreased at ≥6.0 Mg ha–1 (–24%). Liming changed phosphatase activity depending on the management and phosphatase type but did not reflect commonly proposed pH optima of phosphatases. In UNF and MIN, acid phosphomonoesterase activity decreased with pH, and alkaline phosphomonoesterase and phosphodiesterase activity showed minor changes. Liming under ORG altered activity by up to +16% for acid phosphomonoesterase, –16% for alkaline phosphomonoesterase, and +36% for phosphodiesterase. Similar trends were observed for Pmic–normalized activity, including decreased acid phosphomonoesterase under UNF and increased phosphodiesterase under ORG. Pmic–normalized acid phosphomonoesterase activity under ORG was unaffected by liming whereas Pmic–normalized phosphodiesterase activity exhibited a marked decrease under UNF. Across managements, the acid phosphomonoesterase/phosphodiesterase activity ratio peaked at pH 5.0 and decreased thereafter. Despite management‐induced differences in soil P availability, consistent changes in phosphatase activity ratios indicate a short‐term impact of lime on the enzymatic component of P cycling, which could translate to longer‐term changes in Po mineralization and available P.
Electrochemical Analysis of Antipsychotics
Authors: Karadurmus Leyla , Kır Duru , Kurbanoglu Sevinc , Ozkan Sibel A. 
Published: July 2018

Introduction:Schizophrenia is seizures accompanied by severe psychotic symptoms, and a steady state of continuation in the form of periods of stagnation. Antipsychotics are now the basis of treatment for schizophrenia and there is no other molecule that is antipsychotic priority in treatment. Antipsychotics can be classified into two groups; dopamine receptor antagonists such as promazine, fluphenazine etc. and serotonin-dopamine antagonists including risperidone, olanzapine, ziprasidone, aripiprazole etc.Materials and Methods:Electrochemical methods have been used for the determination of antipsychotic agent just as used in the determination of many drug agents. Nearly all of the antipsychotics are electroactive and can be analyzed by electrochemical methods. Electroanalytical methods offer generally high sensitivity, are compatible with modern techniques, have low cost, low requirements, and compact design. Among the most commonly used types, there are cyclic voltammetry, differential pulse voltammetry, square wave voltammetry and linear sweep voltammetry.Conclusion:The aim of this review is to evaluate the main line and the advantages and uses of electroanalytical methods that employed for the determination of antipsychotic medication agents used in schizophrenia. Moreover, applications of the methods to pharmaceutical analysis of Antipsychotics upto- date is also summarized in a table.
EFEK ANTIMIKROBA EKSTRAK ETANOL DAUN PEPAYA (CARICA PAPAYA L) TERHADAP SHIGELLA DYSENTERIAE SECARA IN VITRO DENGAN METODE DILUSI TABUNG DAN DILUSI AGAR
Authors: Ristya Hertanti Senja , Suswati Irma , Setiawan Indra 
Published: July 2018

Efek Antimikroba Ekstrak Etanol Daun Pepaya (Carica papaya, L.) terhadap Shigella dysenteriae secara In Vitro dengan Metode Dilusi Tabung dan Dilusi Agar. Daun pepaya merupakan salah satu tanaman yang mengandung zat aktif, terdiri dari asam organic dan fitosterol, alkaloid, saponin, flavonoid, tannin, dan polifenol berfungsi sebagai antimikroba terhadap bakteri, salah satunya adalah Shigella dysenteriae. Tujuan untuk membuktikan efek antimikroba ekstrak etanol daun pepaya terhadap pertumbuhan bakteri Shigella dysenteriae secara in vitro. Penelitian memakai rancangan true experiments dengan menggunakan Post Test Only Control. Konsentrasi ekstrak daun pepaya yang digunakan adalah 5%, 10%, 15%, 20%, 25%,30% dan 2 kontrol (kontrol bahan dan kontrol kuman). Analisa data menggunakan one way ANOVA, korelasi, dan regresi. Hasil: Nilai KBM (Kadar Bunuh Minimal) pada konsentrasi 30% Hasil uji one way ANOVA menunjukkan adanya perbedaan yang sangat signifikan antar perlakuan (p=0,004). Semakintinggi konsentrasi ekstrak etanol daun pepaya, semakin besar kemampuan menghambat dan membunuh bakteri Shigella dysenteriae (r=-0,472). Pemberian konsentrasi ekstrak etanol daun pepaya berpengaruh terhadap penurunan jumlah koloni bakteri Shigella dysenteriae per ml (106) (R2= 22,3%). Nilai KHM (Kadar Hambat Minimal)pada konsentrasi 10%. Hasil uji one way ANOVA (p=0,066), pada uji korelasi (r=-0,564) dan pada uji regresi didapatkan (R2= 31,9%). Kesimpulan: Ekstrak etanol daun pepaya memiliki efek antimikroba terhadap pertumbuhan koloni Shigella dysenteriae.Kata kunci: Ekstrak etanol daun pepaya, Shigelladysenteriae, KBM, KHM
PENGARUHPEMBERIAN EKSTRAK KUNYIT (CURCUMA LONGA) TERHADAP EKSPRESI SEL GOBLETPADA KONJUNGTIVA TIKUS (RATTUS NOVERGICUS) YANG DIINDUKSI OVALBUMIN
Authors: Puspitasari Wenna , NurHasan Yuliono , Nelasari Halida 
Published: July 2018

ABSTRAKKonjungtivitis merupakan sutau peradangan konjungtiva yang ditandai dengan dilatasi pembuluh darah sehingga konjungtiva menjadi hiperemi, edema dan dapat disertai adanya discharge.Curcuminmerupakanbahanaktifdarikunyit yang memilikimanfaatsebagai anti alergi.Penelitian ini bertujuan untuk mengetahuipengaruhpemberianekstrakkunyit (Curcuma longa) terhadapekspresisel goblet padakonjungtivatikus yang diinduksi ovalbumin. PenelitianinimerupakanpenelitianTrue experimentaldenganpost test only group design. Sampeldibagidalamempatkelompokperlakuan yang diberiekstrakkunyitdengandosismasing-masing 35 mg/200grBB, 70 mg/200grBB, 140 mg/200grBB secaraippadaharike 15 dan 18 satu jam sebelumpemberian ovalbumin sertasatukelompokkontrolpositif yang hanyadiberi ovalbumin padaharike 0,7,15 dan 18. Analisis data menggunakanOnewayAnova, bonferonni, kolerasidanregresi.Ekstrakkunyitdapatmenurunkanjumlahsel goblet secarabermakna (ANOVA p=0,000). Terdapathasilujiregresi linier sebesar 70,0%. Dosis minimal yang menunjukkanefeksignifikanadalah 70 mg/kgBB.Ekstrakkunyitberpengaruhterhadappenurunanjumlahsel goblet padakonjungtivatikus (Rattusnorvegicus) yang diinduksi ovalbumin Kata kunci :KonjungtivitisAlergi, Kurkumin, Ovalbumin
PENGARUH PEMBERIAN RHODAMIN B PERORAL SUBAKUT TERHADAP PERUBAHAN KETINGGIAN MUKOSA GASTER TIKUS PUTIH GALUR WISTAR (Rattus norvegicus Strain Wistar)
Authors: Anjasmara Pravangesta Anggit , Romdhoni Muhammad Fadhol , Purbowati Mustika Ratnaningsih 
Published: July 2018

Latar Belakang : Rhodamin B merupakan zat pewarna sintetis yang digunakan untuk pewarna tekstil, namun banyak disalahgunakan sebagai zat pewarna makanan. Hal ini sangat berbahaya bagi kesehatan karena Rhodamin B mengandung zat kimia yang berbahaya dan reaktif. Jika di konsumi dalam jangka panjang maka akan menyebabkan iritasi saluran cerna dan mengakibatkan gastritis.Tujuan : Mengetahui pengaruh pemberian Rhodamin B peroral subakut terhadap perubahan ketinggian mukosa gaster tikus wistar.Metode : Penelitian ini merupakan penelitian eksperimental dengan rancangan post test only with control design. Sampel berupa 24 tikus wistar jantan yang memenuhi kriteria inklusi dan eksklusi, kemudian diadaptasi dan dibagi secara acak menjadi 4 kelompok. K merupakan kelompok kontrol hanya diberikan makanan dan minuman standar. P1 diberi Rhodamin B peroral 3,5mg/kgBB, P2 diberi Rhodamin B peroral 7mg/kgBB, P3 diberi Rhodamin B peroral 14mg/kgBB. Setelah 30 hari dilakukan terminasi dan diambil organ gaster untuk dibuat preparat histopatologi.Hasil : Rerata ketinggian mukosa gaster pada kelompok K=987,054µm; P1=732,170µm; P2=587,187µm; P3=525,967µm. Hasil uji One Way Anova didapatkan perbedaan ketinggian mukosa pada semua kelompok (P < 0,05) dan uji Post Hoc menggunakan uji LSD didapatkan perbedaan yang bermakna pada K-P1 (P=0,009), K-P2 (P=0,000), K-P3 (P=0,000), P1-P3 (P=0,025). Tetapi tidak terdapat perbedaan bermakna pada P1-P2 (P=0,103) dan P2-P3 (P=0,479). Uji korelasi Spearman didapatkan hubungan negatif yang sangat kuat antara pemberian Rhodamin B dosis bertingkat terhadap perubahan ketinggian mukosa gaster (r=-0,781).Kesimpulan : Pemberian Rhodamin B peroral subakut berpengaruh terhadap perubahan ketinggian mukosa gaster tikus wistar. Semakin tinggi dosis yang diberikan, semakin rendah ketinggian mukosa gaster. Kata Kunci : rhodamin b, ketinggian mukosa gaster, peroral
DISTRIBUSI KASUS KEMATIAN AKIBAT ASFIKSIA DI MALANG RAYA YANG DIPERIKSA DI INSTALASI KEDOKTERAN FORENSIK RSSA TAHUN 2006-2007
Authors: Tasmono H 
Published: July 2018

Kematian akibat Asfiksia dapat disebabkan oleh kejadian ke celakaan, bunuh diri atau pemb unuhan. Yang sering menimbulkan permasalahan adalah kejadian gantung diri apakah akibat bunuh diri atau pembunuhan. Dari beberapa data di beberapa pusat pendidikan kedokteran didapatkan bahwa kejadian as fiksia terbanyak akibat gantung diri kar ena bunuh diri. Pada penelitian Retrospektif ini dilakukan pendataan dan anal isa selama tahun 2006-2007 tentang ju mlah kejadian gantung diri insiden tentang jenis kelamin, umur serta lokasi kejadian. Dari pendataan tersebut didapat kan jumlah kejadian tahun 2006 sebanyak 14 kasus, tahun 2007 seban yak 16 kasus dengan kematian terbanyak akibat gantung diri ( hanging ) dibandingkan dengan burking suffocation maupun penyakit. Pada hanging ( 56% ) korban jenis kelamin laki-laki lebih banyak daripada wanita ( 59% : 41% ) dengan usia terbanyak 31 - 40 tahun yang kedua usia 11 – 20 tahun, sedangkan lokasi kejadian terbanyak di Kabupaten Malang. Kata kunci : Asfiksia, gantung diri ( hanging ).
HUBUNGAN ANTARA BERATNYA MANIFESTASI DERMATITIS ATOPIK DENGAN TINGGINYA SKALA KEPRIBAD IAN CEMAS PADA TES MMPI PADA PENDERITA DERMATITIS ATOPIK WANITA DI RSUD DR. SOETOMO
Authors: Indrawanto Iwan Sis 
Published: July 2018

Dermatitis Atopic, a kind of chronic skin disease that happens a lot in the world, tend to be increased in number and relatively difficult to treat. Most of them appear along with another atop ic condition such as Hay and asthma. The cause is not clearly un derstood yet. It’s thought to be the combination of genetics and environment. Many says that ther e’s emotional factor involved. It’s not the cause of the disease but it worsen or triggers the relaps. People of Dermatitis Atopic with anxious kind of personality have prone to relaps e easier than those who are not. This study figured out whether the degree of Dermatitits Atopic manifestation is correlated with the score o f anxious scale on MMPI of the Dermatitis Atopic female patien ts in Dr. Soetomo Public Hospital Surabaya. The method was analytical study with cr oss sectional approach, started from Juli 2009 until Desember 2009. The datas was taken from policlinics of Skin and Venereal Desease Department of Dr. Sutomo Pu blic Hospital Surabaya. Fivety three samples were taken, while 7 of them were failed due to high invalid MMPI score. The result showed that there was significant correlation between the degree of Dermatitits Atopic manifestation with the score of anxious scale on MMPI of the Dermatitis Atopic female pati ents. The correlation was medium to high. Keywords: Dermatitis Atopic, Anxious Personality, MMPI
MODEL DIAGNOSTIK STROKE BERDASARKAN GEJALA KLINIS
Authors: Bahrudin Mochamad 
Published: July 2018

Abstrak Latar belakang, Stroke menimbulkan masalah besar karena menyebabkan kecacatan dan kematian. Tujauan , Mengetahui profil gejala klinis dominan guna menentukan model diagnosa stroke berdasarkan gejala klinis. Metode, Penelitian dilakukan di RSU Haji Surabaya, RSU jombang dan RSU dr. Soetoma Surabaya, dilakukan secara deskriptif analitik dengan metode cross sectional dan didapatkan sampel penelitian 171 penderita stroke sesuai kriteria inklusi dan eklusi yang ditetapkan. Hasil penelitian, Pasien stroke iskemik 59,1%, stroke perdarahan 40,9%). 4 Gejala klinik dominan ( kesadaran menurun, sakit kepala, tekanan darah systole >=180 dan muntah) mengarah pada stroke perdarahan, dengan test Chi-Square didapatkan hasil yang significant P= 0,000 . Kesimpulan, Pasien stroke dengan 4,3, gejala klinik dominan mengarah ke stroke perdarahan sedang tanpa, 1 dan 2 gejala klinik dominan mengarah ke stroke Iskemik. Kata kunci : stroke, Model Diagnosis Stroke, Gejala klinik dominan.
JUS BELIMBING MANIS (Averrhoa carambola L.) SEBAGAI HEPATOPROTEKTOR PADATIKUS PUTIH (Rattus novergicus strain wistar) YANG DIINDUKSI ANTITUBERKULOSIS RIFAMPISIN DAN ISONIAZID
Authors: Devi Iralawati Antia , Hermayanti Diah , Syafitri Fathiyah 
Published: July 2018

Latar Belakang: Rifampisin dan isoniazid merupakan obat yang direkomendasikan dalam pengobatan Tuberkulosis yang memiliki efek samping hepatotoksisitas. Jus belimbing manis diduga mempunyai efek hepatoprotektor karena mengandung flavonoid, tanin, dan vitamin C. Tujuan: Membuktikan efek hepatoprotektor jus belimbing manis terhadap penurunan kadar SGOT, SGPT, dan MDA tikus putih jantan yang diinduksi rifampisin dan isoniazid. Metode: Eksperimental, Post Test Only Control Group Design. Sampel dibagi 5 kelompok perlakuan. Kontrol negatif, kontrol positif diberi rifampisin dan isoniazid masing-masing 200 mg/KgBB/hari, dan 3 kelompok perlakuan yang diberi rifampisin, isoniazid, dan jus belimbing manis dengan dosis 4 ml/hari, 8 ml/hari, 12 ml/hari selama 14 hari. Data dianalisis dengan uji One-Way ANOVA, uji korelasi, dan uji regresi. Hasil Penelitian dan Diskusi: Analisa statistik dilakukan untuk masing-masing variabel dependent SGOT, SGPT, dan MDA. Uji One-Way ANOVA Sig 0,000<p(0,05) menunjukkanadanya perbedaan yang bermakna antar perlakuan. Uji korelasi Sig 0,000< p(0,05) dengan koefisien sebesar -0,827 dan -0,852, dan -0,555 mempunyai korelasi yang sangat kuat, yaitu semakin tinggi dosis jus belimbing manis maka semakin rendah kadar SGOT dan SGPT. Hasil uji regresi menunjukkan jus belimbing manis berpengaruh terhadap penurunan kadar SGOT , SGPT, dan MDA sebesar 68,4%, 72,6%, dan 27,9%. Dosis jus belimbing manis 12 ml/hari merupakan dosis optimal untuk menurunkan kadar SGOT dan SGPT. Kesimpulan: Jus belimbing manis memiliki efek hepatoprotektor terhadap penurunan kadar SGOT, SGPT, dan MDA tikus putih jantan yang diinduksi rifampisin dan isoniazid.Kata Kunci: Jus belimbing manis (Averrhoa carambola L.), hepatoprotektor, antituberkulosis
Le problème des opioïdes
Authors: Levine Mitch 
Published: July 2018

Au Congrès annuel de la SCMI tenu récemment à Toronto, la séance plénière s’intitulait « La crise des opioïdes en Amérique du Nord ». Ce sujet en est un de grande importance pour les internistes. En effet, dans nos cliniques ou à l’hôpital, nous rencontrons fréquemment des patients qui ont des problèmes de dépendance aux opioïdes et nous nous devons d’avoir une stratégie médicale judicieuse et empreinte de compassion pour prendre en charge ces situations. C’est aussi pour nous l’occasion de contribuer à prévenir un problème qui débute souvent par une prescription médicale.
Late Presentation of Disseminated Bacillus Calmette-Guerin infection in an Immunocompetent Male: a Case Report
Authors: Captan Virgil Vasile , Dokouhaki Pouneh , Solez Kim , Szkotak Artur , Morales Fraulein 
Published: July 2018

Intravesical administration of Bacillus Calmette-Guerin (BCG) is a cornerstone of adjuvant treatment for low-grade urothelial carcinoma. Complications from administration are relatively rare and generally evident within one month. Systemic BCG infections are typically diagnosed within 14 days post BCG administration; however, cases have been reported of infections being diagnosed as late as 17 years after treatment. Here, we describe the unusual case of a 55-year-old immunocompetent male who was diagnosed with disseminated BCG infection 3 years after initial adjuvant treatment for urothelial carcinoma.
Résumé
L'administration intravésicale de Bacillus Calmette-Guerin (BCG) est la pierre angulaire du traitement adjuvant du carcinome urothéliales de faible teneur. Les complications de l'administration sont relativement rares et généralement évidentes dans un délai d'un mois. Les infections systémiques du BCG sont généralement diagnostiquées dans les 14 jours après l'administration du BCG; Toutefois, des cas ont été signalés d'infections diagnostiquées aussi tard que 17 ans après le traitement. Ici, nous décrivons le cas inhabituel d'un mâle immunocompétents de 55 ans qui a été diagnostiqué avec une infection de BCG disséminée 3 ans après le traitement adjuvant initial pour le carcinome urothéliales.
Integrating the Health of Socially Vulnerable Populations into Residency Programs.
Authors: Rannelli Luke , Tang Karen , Kachra Rahim , Desy Janeve , Fabreau Gabriel 
Published: July 2018

In Canada, growing disparities in health disproportionally affect socially vulnerable populations. The Royal College of Physician and Surgeons of Canada has attempted to incorporate health equity for socially vulnerable populations within the competency training objectives set forth for internal medicine (IM) residents. However, trainee exposure to these populations beyond inpatient contact in tertiary care hospitals has not traditionally been a requirement of IM training. At the University of Calgary, we have developed a four-week clinical rotation that aims to expose residents to social determinants for socially vulnerable populations.
To our knowledge this is the first clinical rotation within an IM program in Canada dedicated to exposing and educating residents on the broader care of socially vulnerable populations. Our goal is to train internists and subspecialists to gain the empathy, skills, and knowledge to better provide care for socially vulnerable populations and to advocate for health equity, throughout their careers.
Résumé
Au Canada, les disparités croissantes de santé affectent de manière disproportionnée les populations socialement vulnérables. Le Collège royal des médecins et chirurgiens du Canada a tenté d'intégrer l'équité en santé pour les populations socialement vulnérables dans les objectifs de formation aux compétences énoncés pour les résidents en médecine interne (GI). Toutefois, l'exposition des stagiaires à ces populations au-delà des contacts avec les patients hospitalisés dans les hôpitaux de soins tertiaires n'a pas toujours été une exigence de la formation en GI. À l'Université de Calgary, nous avons mis au point une rotation clinique de quatre semaines qui vise à exposer les résidents aux déterminants sociaux des populations socialement vulnérables.
À notre connaissance, il s'agit de la première rotation clinique au sein d'un programme de GI au Canada consacré à l'exposition et à l'éducation des résidents sur les soins plus larges des populations socialement vulnérables. Notre objectif est de former des internistes et des sous-spécialités pour acquérir l'empathie, les compétences et les connaissances pour mieux fournir des soins aux populations socialement vulnérables et pour plaider en faveur de l'équité en santé, tout au long de leur carrière.
Use of Rivaroxaban for Prophylaxis of Superficial Venous Thrombosis in Klippel-Trenaunay-Weber Syndrome
Authors: Qamar Hina , Wu Cynthia 
Published: July 2018

Klippel-Trenaunay-Weber syndrome (KTWS) is a congenital malformation syndrome involving blood and lymph vessels and disturbed bone and soft tissue growth. Complications of KTWS include deep-vein thrombosis, pulmonary embolism, gastrointestinal bleeding, and vascular (usually lymphatic) blebs within capillary malformations. We present a case of a young male patient with KTWS who presented with superficial venous thrombosis and microangiopathic hemolytic anemia in a presentation similar to disseminated intravascular coagulation. He was ultimately maintained on prophylactic rivaroxaban to prevent recurrent thrombotic events. We performed a literature search to identify similar cases and to summarize common presenting features and treatment modalities that were offered.
Résumé
Le syndrome de Klippel-Trenaunay-Weber (KTWS) est un syndrome de malformation congénitale impliquant le sang et les vaisseaux lymphatiques et les os perturbés et la croissance des tissus mous. Les complications de la KTWS comprennent la thrombose veineuse profonde, l'embolie pulmonaire, les saignements gastro-intestinaux et les bulles vasculaires (habituellement lymphatiques) dans les malformations capillaires. Nous présentons un cas d'un jeune patient mâle avec KTWS qui a présenté une thrombose veineuse superficielle et une anémie hémolytique microangiopathique dans une présentation semblable à la coagulation intravasculaire disséminée. Il a finalement été maintenu sur des rivaroxaban prophylactiques pour prévenir les épisodes récurrents de purpura. Nous avons effectué une recherche documentaire pour identifier des cas similaires et pour résumer les caractéristiques communes de présentation et les modalités de traitement qui ont été offerts.