bluuebunny/crossref_metadata_2025_split huggingface dataset:
Lineage tracing suggests that ovarian endosalpingiosis does not result from escape of oviductal epithelium
Authors: Wang Yisheng , Sessine Michael S , Zhai Yali , Tipton Courtney , McCool Kevin , Kuick Rork , Connolly Denise C , Fearon Eric R , Cho Kathleen R 
Published: May 2019

AbstractMost high‐grade serous carcinomas are thought to arise from Fallopian tube epithelium (FTE), but some likely arise outside of the tube, perhaps from ectopic tubal‐type epithelium known as endosalpingiosis. Importantly, the origin of endosalpingiosis is poorly understood. The proximity of the tubal fimbriae to the ovaries has led to the proposal that disruptions in the ovarian surface that occur during ovulation may allow detached FTE to implant in the ovary and form tubal‐type glands and cysts. An alternative model suggests that cells present in ectopic locations outside the Müllerian tract retain the capacity for multi‐lineage differentiation and can form glands with tubal‐type epithelium. We used double transgenic Ovgp1‐iCreERT2;R26RLSL‐eYFP mice, which express an eYFP reporter protein in OVGP1‐positive tissues following transient tamoxifen (TAM) treatment, to track the fate of oviductal epithelial cells. Cohorts of adult mice were given TAM to activate eYFP expression in oviductal epithelium, and ovaries were examined at time points ranging from 2 days to 12 months post‐TAM. To test whether superovulation might increase acquisition of endosalpingiosis, additional cohorts of TAM‐treated mice underwent up to five cycles of superovulation and ovaries were examined at 1, 6, and 12 months post‐TAM. Ovaries were sectioned in their entirety to identify endosalpingiosis. Immunohistochemical staining for PAX8, tubulin, OVGP1, and eYFP was employed to study endosalpingiosis lesions. Ovarian endosalpingiosis was identified in 14.2% of TAM‐treated adult mice. The endosalpingiotic inclusion glands and cysts were lined by secretory and ciliated cells and expressed PAX8, tubulin, OVGP1, and eYFP. Neither age nor superovulation was associated with a significant increase in endosalpingiosis. Endosalpingiosis was also occasionally present in the ovaries of pre‐pubertal mice. The findings imply that ovarian endosalpingiosis in the mouse does not likely arise as a consequence of detachment and implantation of tubal epithelium and other mechanisms may be relevant. © 2019 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
Mucormycosis diagnosed during induction chemotherapy in five pediatric patients with acute lymphoblastic leukemia
Authors: Aftandilian Catherine , Eguiguren Lourdes , Mathew Roshni , Messner Anna 
Published: May 2019

AbstractMucormycosis in pediatric oncology patients is a rare invasive fungal infection associated with significant morbidity and mortality. We describe five patients diagnosed with mucormycosis during induction chemotherapy for acute lymphoblastic leukemia at our institution. All of the patients in our series survived, some in spite of having disseminated disease. Most of the patients’ chemotherapy was modified with the aim of controlling their leukemia while minimizing immunosuppression until their fungal infection was under control. Although mucormycosis is frequently fatal, rapid diagnosis and a multidisciplinary approach can lead to excellent outcomes, even in patients undergoing intensive chemotherapy.
Safety profile of traditional Chinese herbal injection: An analysis of a spontaneous reporting system in China
Authors: Li Haona , Deng Jianxiong , Deng Lewen , Ren Xuequn , Xia Jielai 
Published: May 2019

AbstractPurposeAlthough a series of serious adverse events have continually raised concerns about the potential toxicity of traditional Chinese medicine injections (TCM injections), studies on this subject are still sparse. We conducted a descriptive analysis of a spontaneous reporting system in China to describe the safety profile of TCM injections.MethodsThe safety profile of TCM injections is described by descriptive analysis of 559 066 adverse reports collected from Guangdong Provincial Center for adverse drug reaction (ADR) Monitoring in China during 2003 to 2017.ResultsThe percentage of new or serious ADRs of TCM injections is much higher than average percentage of China's spontaneous reporting system (SRS) as a whole (48.70% vs <25%). Compared with conventional injections, TCM injections have a slightly lower percentage of serious ADRs (6.02% vs 6.72%) and much higher percentage of unknown (new) ADRs (46.74% vs 24.13%). The gender and age distribution for TCM injections are similar to conventional injections. The reporting rates of ADRs increased with age. Anaphylactic shock and anaphylactoid reaction are high‐risk ADRs for TCM injections and, anaphylactic shock is ranked number 1 in causing deaths (50.00%).ConclusionsThere are some differences and similarities on the safety profile between TCM injections and conventional injections. TCM injections have higher risk of adverse effects than any other dosage forms of TCM medications and higher percentage of new or serious adverse effects than conventional injections. A lot of work need to be done to clarify the huge amount of potential unknown adverse effects related to TCM injections.
Morphology and ionic conductivity relationship in silk/cellulose biocomposites
Authors: Blessing Bailey , Trout Cory , Morales Abneris , Rybacki Karleena , Love Stacy A , Lamoureux Guillaume , O'Malley Sean M , Hu Xiao , Salas‐de la Cruz David 
Published: May 2019

AbstractThe relationship between morphology and the ionic conductivity of polysaccharide–protein bio‐electrolyte membranes is explored in this study. Structural proteins and polysaccharides form hydrophobic and electrostatic interactions, and the resulting matrices can exhibit novel and useful properties. However, transforming these natural biomacromolecules from their native state to a more usable form is challenging. The structural, morphological, thermal, mechanical and electrical properties of biomaterials composed of microcrystalline cellulose and Bombyx mori silk when regenerated together using ionic liquids and various coagulation agents were investigated using a diverse set of techniques including Fourier transform infrared spectroscopy, SEM, TGA, DSC, X‐ray scattering, AFM‐based nanoindentation and dielectric relaxation spectroscopy. The surface topography of the films reveals morphological changes with varying coagulation agents and ionic liquids. It was found that the thermal and mechanical properties were dependent on intermolecular interactions dictated by the type of ionic liquid used during the coagulation process. X‐ray scattering provided information on how the cellulose crystallinity varied with coagulation agent. Specifically, samples coagulated with hydrogen peroxide showed an increase in cellulose crystallinity impacting properties such as elasticity, hardness and ionic conductivity of the biocomposites. In addition, the results revealed a strong correlation between β‐sheet content and ionic conductivity and cellulose crystallinity. The results provided evidence that the ionic conductivity is dependent on protein β‐sheet content and cellulose crystallinity. © 2019 Society of Chemical Industry
Electronic structure of GaP/Si(001) heterojunctions and the role of hydrogen passivation
Authors: Meidanshahi Reza Vatan , Zhang Chaomin , Zou Yongjie , Honsberg Christiana , Goodnick Stephen M. 
Published: May 2019

AbstractEpitaxially grown single crystal GaP on Si is of considerable interest due to being nearly lattice matched to Si, making it attractive for III‐V/Si solar cells. GaP has been used as a buffer layer for III‐V/Si solar cells and also in selective contact Si solar cells. The performance and functionality of such devices are strongly influenced by the presence of localized states at the GaP/Si interface. Here, we examine the electronic structure of GaP/Si(001) heterojunctions and the effect of hydrogen (H) passivation at the interface, in contrast to interface mixing, through density functional theory calculations. Our calculations show that due to the heterovalent mismatch nature of the GaP/Si interface, there is a high density of localized states at the abrupt GaP/Si interface due to the excess charge associated with heterovalent bonding, as reported elsewhere. We find that the addition of H leads to additional bonding at the interface, which mitigates the charge imbalance, and greatly reduces the density of localized states, leading to a nearly ideal heterojunction. A similar result is found with a completely intermixed interface (alternating cation and anion bonding) in terms of low interface state density. However, when the intermixing occurs through single‐layer or double‐layer terraces, the benefits of intermixing are lost and the interface state density reverts more to the abrupt interface case.
Toward Axonal System Biology: Genome Wide Views of Local mRNA Translation
Authors: Farias Joaquina , Sotelo José Roberto , Sotelo‐Silveira José 
Published: May 2019

AbstractNeurons present a highly polarized morphology, often displaying a significantly imbalanced distribution of the cytoplasm between the somatic and axonal domains. This imbalance requires cell‐specific mechanisms for the maintenance of the axoplasmic mass during development, neuronal homeostasis, and recovery after injury. Although it has been clearly demonstrated that axoplasmic transport contributes a large amount of proteins to the axons, local protein synthesis has been fully accepted as an important complementary source of proteins, which aids in the maintenance of the axoplasmic mass in both normal and regenerating conditions. This review analyzes and highlights the most important advances in the knowledge of the axonal transcriptome, translatome, and proteome at a genome‐wide scale. It is discussed how this knowledge has provided researchers with new insights regarding the involvement of local protein synthesis in many key neuronal functions. In addition, challenges, open questions, and methods currently available to study axonal mRNA localization and protein synthesis are addressed.
Geometric Quantum Computation with Shortcuts to Adiabaticity
Authors: Du Yanxiong , Liang Zhentao , Yan Hui , Zhu Shiliang 
Published: May 2019

AbstractRealization of a large‐scale quantum computation relies on fast and high‐fidelity quantum control. Geometric quantum control is thought to be a promising candidate for quantum computation which consolidates the robustness against both random noise (through the global geometrical feature) and systematic errors (through adiabatic characteristic). The adiabatic process of geometric control can be accelerated through an auxiliary Hamiltonian in different scenarios by means of shortcuts to adiabaticity (STA). Especially, the auxiliary Hamiltonian can be absorbed into the original interacting configuration in most of the cases, which allows STA to coalesce with the Abelian or the non‐Abelian geometric control. As a consequence, geometric quantum control can have an enhanced robustness against decoherence after speeding up by STA. Here, the recent theoretical and experimental advances in geometric quantum computation based on STA are reviewed.
Preparation of a Poly(ethylene glycol)‐Based Cross‐Linked Network from a Click Reaction for Enzyme Immobilization
Authors: Oktay Burcu , Demir Serap , Kayaman‐Apohan Nilhan 
Published: May 2019

AbstractIn this study, a polyethylene glycol (PEG)‐maleimide film was prepared by a thiol‐ene click reaction. The covalent immobilization of amylase was carried out onto the PEG‐maleimide based photo‐curable network via epoxy and C=O groups without any linker. The epoxy and carbonyl groups on the PEG backbone improved the affinity of the enzyme. The immobilization yield of amylase onto the film was 72.46%. The immobilization capacity was also determined as 313 mg/g. The thermal stability of amylase improved via covalent attachment. Immobilized amylase showed maximum activity at 40 °C and pH 6.5. The immobilized amylase continued to retain 66% of its initial activity after 30 days.
Thermochemical Conversion of Guaiacol in Aqueous Phase by Density Functional Theory
Authors: Agrawal Kushagra , Verma Anand M. , Kishore Nanda 
Published: May 2019

AbstractThe conversion of guaiacol to benzene, toluene and o‐cresol along with several important intermediates like phenol, catechol and others in aqueous phase has been theoretically studied under the framework of density functional theory (DFT). The bond dissociation energy (BDE) calculation has been performed on optimized structures of guaiacol, phenol and anisole; and accordingly several reaction pathways have been proposed. The thermochemical parameters like Gibb's free energy change and enthalpy change of the reactions have also been reported using M06‐2X functional. In BDE study of the three compounds, i. e., guaiacol, phenol and anisole, it is observed that the scission of H. at fifth carbon position of an aromatic ring is the highest energy demanding dissociation, whereas the cleavage of bond from the functional group attached to the aromatic ring has the least BDE. The formation of phenol from guaiacol is more likely to occur by simultaneous hydrogenation and demethoxylation of guaiacol amongst all proposed pathways in aqueous phase. Further, decomposition of phenol to benzene is likely to occur via direct dehydroxylation of phenol. The simultaneous hydrogenation and dehydroxylation of guaiacol in aqueous phase are most likely to produce anisole which can further be reduced to phenol by direct cleavage of methyl group followed by hydrogenation. Further, free energy change landscape shows the conversion of guaiacol to phenol to be kinetically most favourable conversion at low temperature and high pressure in the aqueous phase. Finally, the increase in temperature causes a decrease in Gibb's free energy change and enthalpy change of overall reactions, thereby increasing favourability of most of the reactions in aqueous phase. Furthermore, the comparison between gaseous and aqueous phase results have been made wherever applicable.
Graphene/Carbon Black Co‐modified Separator as Polysulfides Trapper for Li‐S Batteries
Authors: Zhang Kangming , Dai Liqin , Xie Lijing , Kong Qingqiang , Su Fangyuan , Liu Zhuo , Shi Jing , Liu Yanzhen , Chen Zhiwen , Chen Chengmeng 
Published: May 2019

AbstractLithium‐sulfur batteries are widely concerned because of their high energy density. However, its application is limited by the shuttle effect of polysulfides. In this work, the reduced graphene oxide/carbon black co‐modified separator is fabricated using the vacuum filtration method. The initial discharge specific capacity of lithium‐sulfur battery with reduced graphene oxide/carbon black (1:1) separator reaches 1014.5 mAh g−1 at 0.2 C and the capacity decay rate is only 0.17% per cycle, which shows excellent cycling stability. Furthermore, the capacity retention ratio is 75.47% at 1 C after 500 cycles. Particularly, it shows outstanding performance at high current density, and the specific capacity keeps at 612.2 mAh g−1 even at 5 C. The excellent electrochemical performance can be attributed to the physical adsorption of abundant pores and the chemical adsorption of hydroxyl functional group, providing strong capability for trap polysulfides. The co‐modified separator not only serves as trapper to inhibit the shuttle effect of polysulfides, but also acts as upper current collector for the reuse of captured polysulfides. This simple and controllable preparation method can be applied in the design of long‐cycle life and high power density of lithium‐sulfur batteries.
Hydrogenolysis of Biomass‐Derived 5‐Hydroxymethylfurfural to Produce 2,5‐Dimethylfuran Over Ru‐ZrO2‐MCM‐41 Catalyst
Authors: Raut Amol B. , Nanda Binita , Parida Kulamani M. , Bhanage Bhalchandra M. 
Published: May 2019

AbstractIn this work, an effective catalytic route for the selective hydrogenolysis of renewable biomass‐derived 5‐hydroxymethylfurfural (HMF) to high quality bio‐fuel 2,5‐dimethylfuran (DMF) was reported using Ru supported on ZrO2‐MCM‐41. The synthesized Ru supported on ZrO2‐MCM‐41 catalyst was characterized by different techniques such as XRD, BET surface area, XPS, SEM, TEM, EDX, TGA and TPD. Reaction parameters, like time, metal loading on ZrO2‐MCM‐41, catalyst loading, temperature, H2 pressure and solvent, were optimized for the conversion of HMF to DMF using prepared catalyst. The investigation performed in this study shows that Ru supported on ZrO2‐MCM‐41 is highly active and selective catalyst for effective transformation of the HMF into DMF in high yield and selectivity. With the use of 2 wt % Ru‐ZrO2‐MCM‐41 catalyst, 90% yield of DMF was obtained from HMF with very short reaction time of 1 h. The catalyst was recycled upto six time with slight decrease in yield after 4th cycle. A direct conversion of Fructose to DMF was also achieved in 53% yield using Amberlyst‐15 and 2%Ru‐ZrO2‐MCM‐41 combined catalyst in n‐butanol.
High Photocatalytic Performance of Pd/PdO‐Supported BiVO4 Nanoparticles for Rhodamine B Degradation under Visible LED Light Irradiation
Authors: Nguyen Trinh Duy , Cao Vu Dai , Nong Linh Xuan , Nguyen Vinh Huu , Bach Long Giang , Le Nhan Thi Hong , Luu Tuan Duy , Hong Seong Soo , Lim Kwon Taek , Vo Dai‐Viet N. 
Published: May 2019

AbstractPd/PdO‐decorated BiVO4 nanoparticles were prepared by two‐step router: (i) monoclinic scheelite BiVO4 nanoparticles were fabricated via the co‐precipitation process in the presence of urea; (ii) Pd/PdO was decorated BiVO4 surface by the combination of by precipitation method and annealing process. The as‐synthesized catalysts were characterized by X‐ray powder diffraction (XRD) analysis, Raman spectra, X‐ray photoelectron (XPS) spectra, UV‐visible diffuse reflectance (UV‐vis DRS) spectra, and photoluminescence (PL) spectroscopy. The photocatalytic performance of Pd/PdO‐decorated BiVO4 samples exhibited excellent photodegradation of rhodamine B as well as the OH• radical generation under LED light irradiation as a comparison with the bare BiVO4. This excellent outcome is due to the reduced electron/hole recombination of Pd/PdO‐decorated BiVO4 samples, which was confirmed by PL characterization. Therefore, the fabrication of semiconductors with a combination of noble metal/oxides are good candidates for enhancement of their photocatalytic performance.
M13 Virus‐Based Framework for High Fluorescence Enhancement
Authors: Huang Shengnan , Qi Jifa , deQuilettes Dane W. , Huang Mantao , Lin Ching‐Wei , Bardhan Neelkanth M. , Dang Xiangnan , Bulović Vladimir , Belcher Angela M. 
Published: May 2019

AbstractFluorescence imaging is a powerful tool for studying biologically relevant macromolecules, but its applicability is often limited by the fluorescent probe, which must demonstrate both high site‐specificity and emission efficiency. In this regard, M13 virus, a versatile biological scaffold, has previously been used to both assemble fluorophores on its viral capsid with molecular precision and to also target a variety of cells. Although M13‐fluorophore systems are highly selective, these complexes typically suffer from poor molecular detection limits due to low absorption cross‐sections and moderate quantum yields. To overcome these challenges, a coassembly of the M13 virus, cyanine 3 dye, and silver nanoparticles is developed to create a fluorescent tag capable of binding with molecular precision with high emissivity. Enhanced emission of cyanine 3 of up to 24‐fold is achieved by varying nanoparticle size and particle‐fluorophore separation. In addition, it is found that the fluorescence enhancement increases with increasing dye surface density on the viral capsid. Finally, this highly fluorescent probe is applied for in vitro staining of E. coli. These results demonstrate an inexpensive framework for achieving tuned fluorescence enhancements. The methodology developed in this work is potentially amendable to fluorescent detection of a wide range of M13/cell combinations.
Weight discordance and perinatal mortality in monoamniotic twin pregnancy: analysis of MONOMONO, NorSTAMP and STORK multiple‐pregnancy cohorts
Authors: Saccone G. , Khalil A. , Thilaganathan B. , Glinianaia S. V. , Berghella V. , D'Antonio F. ,   for the MONOMONO, NorSTAMP and STORK research collaboratives
Published: May 2019

ABSTRACTObjectivesThe primary objective was to quantify the risk of perinatal mortality in non‐anomalous monochorionic monoamniotic (MCMA) twin pregnancies complicated by birth‐weight (BW) discordance. The secondary objectives were to investigate the effect of inpatient vs outpatient fetal monitoring on the risk of mortality in weight‐discordant MCMA twin pregnancies, and to explore the predictive accuracy of BW discordance for perinatal mortality.MethodsThis analysis included data on 242 MCMA twin pregnancies (484 fetuses) from three major research collaboratives on twin pregnancy (MONOMONO, STORK and NorSTAMP). The primary outcomes were the risks of intrauterine (IUD), neonatal (NND) and perinatal (PND) death, according to weight discordance at birth from ≥ 10% to ≥ 30%. The secondary outcomes were the association of inpatient vs outpatient fetal monitoring with the risk of mortality in weight‐discordant pregnancies, and the accuracy of BW discordance in predicting mortality. Logistic regression and receiver‐operating‐characteristics‐curve analyses were used to analyze the data.ResultsThe risk of IUD was significantly increased in MCMA twin pregnancies with BW discordance ≥ 10% (odds ratio (OR), 2.2; 95% CI, 1.1–4.4; P = 0.022) and increased up to an OR of 4.4 (95% CI, 1.3–14.4; P = 0.001) in those with BW discordance ≥ 30%. This association remained significant on multivariate logistic regression analysis for BW‐discordance cut‐offs ≥ 20%. However, weight discordance had low predictive accuracy for mortality, with areas under the receiver‐operating‐characteristics curve of 0.60 (95% CI, 0.46–0.73), 0.52 (95% CI, 0.33–0.72) and 0.57 (95% CI, 0.45–0.68) for IUD, NND and PND, respectively. There was no difference in the risk of overall IUD, single IUD, double IUD, NND or PND between pregnancies managed as an inpatient compared with those managed as an outpatient, for any BW‐discordance cut‐off.ConclusionsMCMA twin pregnancies with BW discordance are at increased risk of fetal death, signaling a need for increased levels of monitoring. Despite this, the predictive accuracy for mortality is low; thus, detection of BW discordance alone should not trigger intervention, such as iatrogenic delivery. The current data do not demonstrate an advantage of inpatient over outpatient management in these cases. Copyright © 2019 ISUOG. Published by John Wiley & Sons Ltd.