bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Multicenter Cohort Study on DNA Methylation for Endometrial Cancer Detection in Cervical Scrapings
Authors: Ma Xiao , Chen Xiaojun , Liang Jing , Zhang Jingbo , Wu Qixi , Wang Dong , Huang Xianghua , Zi Dan , Chen Dexin , Wan Hua , Qu Li , Jiang Zhaoyun , Shao Wenyu , Sun Jie , Chang Luyuan , Liu Yunchao , Zhang Qin , Li Yanan , Ding Yani , Tang Biao , Zhao Fang , Zhao Hanqing , Cao Dongyan 
Published: November 2024

ABSTRACTBackgroundThe increasing incidence of endometrial cancer (EC) has highlighted the need for improved early detection methods. This study aimed to develop and validate a novel DNA methylation classifier, EMPap, for EC detection using cervical scrapings.MethodsEMPap incorporated the methylation status of BHLHE22 and CDO1, along with age and body mass index (BMI), into a logistic regression model to calculate the endometrial cancer methylation (EM) score for identifying EC in cervical scrapings. We enrolled 1297 patients with highly suspected EC, including 196 confirmed EC cases, and assessed the EMPap performance in detecting EC.ResultsEMPap demonstrated robust diagnostic accuracy, with an area under the curve of 0.93, sensitivity of 90.3%, and specificity of 89.3%. It effectively detected EC across various disease stages, grades, and histological subtypes, and consistently performed well across patient demographics and symptoms. EMPap correctly identified 87.5% of the type II ECs and 53.8% of premalignant lesions. Notably, compared with transvaginal ultrasonography (TVS) in patients with postmenopausal bleeding, EMPap exhibited superior sensitivity (100% vs. 82.0%) and specificity (85.2% vs. 38.5%). In asymptomatic postmenopausal women, EMPap maintained high sensitivity (89.5%) and negative predictive value (NPV) (98.3%).ConclusionsThis study demonstrated the potential of EMPap as an effective tool for EC detection. Despite the limited sample size, EMPap showed promise for identifying type II EC and detecting over 50% of premalignant lesions. As a DNA methylation classifier, EMPap can reduce unnecessary uterine interventions and improve diagnosis and outcomes.
The hidden emotions of therapists: An autoethnographic exploration of working with clients who self‐injure
Authors: Naxton Joanna 
Published: November 2024

AbstractIntroductionThis paper explores how working with clients who self‐injure generates significant emotional reactions in therapists, often difficult to manage. Drawing on my clinical experience as a researcher and counsellor, I provide an evocative autoethnographic account, highlighting hidden, forbidden or taboo feelings. The aim was to deepen understanding of therapists' emotional realities and contribute to the limited literature on this subject.MethodThrough journaling, sketching, metaphor and field notes, I detail personal experiences with clients who self‐injure. This autoethnography explores my emotions and reactions. A case vignette illustrates my experiences, promoting critical and empathic consideration of how therapist emotions are experienced.Data AnalysisI use autoethnographic methods to analyse the emotional impact and existential reflections of working with clients who self‐injure, employing layers of qualitative interpretation from various personal data sources.ResultsFindings reveal that working with clients who self‐injure forces me to confront my mortality, evoking deep existential reflections and intense emotions like vulnerability and fear. This disrupts my sense of immortality, highlighting my role's limitations and evoking shame and self‐doubt about my ability to alleviate suffering.Implications for PracticeThis paper advances research on self‐injury and emphasises autoethnography as a valuable avenue for counsellors engaging in research. Grounded in PhD study, this paper makes an original contribution to knowledge. Integrating discussions on mortality and emotional vulnerability into supervision and training is crucial, alongside comprehensive training that addresses emotional and unconscious issues. Accessible supervision fosters growth, reduces stigma and supports therapists working with clients who self‐injure.
Association Between Stress, Neuroinflammation, and Irritable Bowel Syndrome: The Positive Effects of Probiotic Therapy
Authors: Azarfarin Maryam , Moradikor Nasrollah , Matin Somaieh , Dadkhah Masoomeh 
Published: November 2024

ABSTRACTStress refers to an organism's response to environmental threats in normal condition to maintain homeostasis in the body. In addition, strong inflammatory reactions induced by the hypothalamic–pituitary–adrenal (HPA) axis under stress condition during a long time. Reciprocally, chronic stress can induce the irritable bowel syndrome (IBS) which is a well‐known gut disorder thereby play an important role in the promotion and pathophysiology of neuropsychiatric diseases. It has been demonstrated that leaky gut is a hallmark of IBS, leads to the entrance the microbiota into the bloodstream and consequent low‐grade systemic inflammation. In the current review, we will discuss the mechanisms by which stress can influence the risk and severity of IBS and its relationship with neuroinflammation. Also, the role of probiotics in IBS co‐existing with chronic stress conditions is highlighted.
Combination of bolus and continuous infusion of factor VIII in a patient with severe hemophilia A undergoing on‐pump coronary artery bypass graft surgery
Authors: Vander Zwaag Stanislaw , Brose Stefan , Fassl Jens 
Published: November 2024

Key Clinical MessagePatients with hemophilia A can safely undergo cardiac surgery. Combining continuous infusion and boluses of factor VIII is both safe and cost‐effective. Interdisciplinary approach and meticulous planning are crucial in the prevention of bleeding complications.
Exploring the dual role of endoplasmic reticulum stress in urological cancers: Implications for tumor progression and cell death interactions
Authors: Farahani Najma , Alimohammadi Mina , Raei Mehdi , Nabavi Noushin , Aref Amir Reza , Hushmandi Kiavash , Daneshi Salman , Razzaghi Alireza , Taheriazam Afshin , Hashemi Mehrdad 
Published: November 2024

AbstractThe endoplasmic reticulum (ER) is crucial for maintaining calcium balance, lipid biosynthesis, and protein folding. Disruptions in ER homeostasis, often due to the accumulation of misfolded or unfolded proteins, lead to ER stress, which plays a significant role in various diseases, especially cancer. Urological cancers, which account for high male mortality worldwide, pose a persistent challenge due to their incurability and tendency to develop drug resistance. Among the numerous dysregulated biological mechanisms, ER stress is a key factor in the progression and treatment response of these cancers. This review highlights the dual role of aberrant ER stress activation in urologic cancers, affecting both tumor growth and therapeutic outcomes. While ER stress can support tumor growth through pro‐survival autophagy, it primarily inhibits cancer progression via apoptosis and pro‐death autophagy. Interestingly, ER stress can paradoxically aid cancer progression through mechanisms such as exosome‐mediated immune evasion. Additionally, the review examines how pharmacological interventions, particularly with phytochemicals, can stimulate ER stress‐mediated tumor suppression. Key regulators, including PERK, IRE1α, and ATF6, are discussed for their roles in upregulating CHOP levels and triggering apoptosis. In conclusion, a deeper understanding of ER stress in urological cancers not only clarifies the complex interactions between cellular stress and cancer progression but also provides new opportunities for innovative therapeutic strategies.
Zinc Bioinspired Catalytic System for the Valorization of CO2 Into Cyclic Carbonates
Authors: Dias Hugo , Tuel Alain , Christ Lorraine 
Published: November 2024

AbstractCyclic organic carbonates are defined as key compounds for a sustainable chemical economy. Their synthesis from CO2 under mild conditions is a useful way to valorise this greenhouse gas as carbon source. Even if a wide range of catalysts were described to promote the carbon dioxide cycloaddition into epoxides, only few ones concern enzymatic systems. The zinc–l‐histidine active site of carbonic anhydrase inspired the present work, pointing out that the imidazole moiety of the amino acid ligand has a crucial role. An extensive study was undertaken to establish the structure–activity relationship of imidazole derivatives, zinc salts, and their respective catalytic activity in the CO2 cycloaddition reaction. The effect of aromatic, alkyl, or iodine substituents and their position in N‐heterocycles were highlighted. A synergic effect was noted when combining imidazole compounds with zinc salts. The optimization of reaction conditions emphasised the in situ ZnI2–1‐methylimidazole catalytic system, which is selective toward cyclic styrene carbonates and efficient under solvent‐free mild conditions (50 °C, atmospheric CO2 pressure). Once reusing tests confirmed the catalytic system robustness, the reaction scope was enlarged to several epoxides resulting in 84%–99% yields of their corresponding cyclic carbonates.
Pesticides and prostate cancer incidence and mortality: An environment‐wide association study
Authors: Soerensen Simon John Christoph , Lim David S. , Montez‐Rath Maria E. , Chertow Glenn M. , Chung Benjamin I. , Rehkopf David H. , Leppert John T. 
Published: November 2024

AbstractBackgroundProstate cancer is the most common cancer among men in the United States, yet modifiable risk factors remain elusive. In this study, the authors investigated the potential role of agricultural pesticide exposure in prostate cancer incidence and mortality.MethodsFor this environment‐wide association study (EWAS), linear regression was used to analyze county‐level associations between the annual use of 295 distinct pesticides (measured in kg per county) and prostate cancer incidence and mortality rates in the contiguous United States. Data were analyzed in two cohorts: 1997–2001 pesticide use with 2011–2015 outcomes (discovery) and 2002–2006 use with 2016–2020 outcomes (replication). The reported effect sizes highlight how a 1‐standard‐deviation increase in log‐transformed pesticide use (kg per county) corresponds to changes in incidence. Analyses were adjusted for county‐level demographics, agricultural data, and multiple testing.ResultsTwenty‐two pesticides showed consistent, direct associations with prostate cancer incidence across both cohorts. Of these, four pesticides were also associated with prostate cancer mortality. In the replication cohort, each 1‐standard‐deviation increase in log‐transformed pesticide use corresponded to incidence increases per 100,000 individuals (trifluralin, 6.56 [95% confidence interval (CI), 5.04–8.07]; cloransulam‐methyl, 6.18 [95% CI, 4.06–8.31]; diflufenzopyr, 3.20 [95% CI, 1.09–5.31]; and thiamethoxam, 2.82 [95% CI, 1.14–4.50]). Limitations included ecological study design, potential unmeasured confounding, and lack of individual‐level exposure data.ConclusionsThe results of this study suggest a potential link between certain pesticides and increased prostate cancer incidence and mortality. These findings warrant further investigation of these specific pesticides to confirm their role in prostate cancer risk and to develop potential public health interventions.
Effects of a culturally tailored patient navigation program on unmet supportive care needs in Hispanic/Latino cancer survivors: A randomized controlled trial
Authors: Noriega Esquives Blanca S. , Moreno Patricia I. , Munoz Edgar , Lad Thomas E. , Hollowell Courtney M. P. , Benzo Roberto M. , Ramirez Amelie G. , Penedo Frank J. 
Published: November 2024

AbstractBackgroundPatient navigation (PN) is a promising yet underused approach to address Hispanic/Latino (H/L) cancer survivors' unmet supportive care needs. The authors conducted a randomized trial to evaluate the effect of a culturally tailored PN program with the LIVESTRONG Foundation's Cancer Navigation Services (PN‐LCNS) on reducing unmet needs in H/L survivors.MethodsFrom 2012 to 2015 at two US sites, 288 H/L survivors diagnosed with breast, prostate, or colorectal cancer were randomized to a PN‐LCNS program or to standard PN. Participants assigned to the PN‐LCNS program received 3‐month PN services; access to phone‐based, bilingual, one‐on‐one support; and additional resources (i.e., guidebook, health journal, and care plan). Participants completed assessments at baseline and at 3, 9, and 15 months post‐baseline. The Supportive Care Needs Survey was used to assess unmet needs across five domains: psychological, health system and information, physical and daily living, patient care and support, and sexuality. Intervention effects were tested by using separate multilevel growth models for women and men.ResultsWomen randomized to the PN‐LCNS program, relative to those who received standard PN, had a statistically significant reduction in unmet needs (i.e., overall and for the health systems and information, physical and daily living, and patient care and support domains). Among men, younger age was associated with greater unmet needs at baseline. Prostate cancer survivors reported greater unmet sexual health needs compared with colorectal cancer survivors. There was no significant change in unmet needs among H/L men.ConclusionsA culturally tailored PN program can reduce unmet supportive care needs among H/L women cancer survivors. However, interventions specifically targeting unmet needs in H/L men and sexual health are still necessary (ClinicalTrials.gov identifier NCT02275754).Plain Language Summary

Hispanic/Latino (H/L) cancer survivors often report concerns or needs that are not adequately addressed by the health care team, which could be related to psychological, health system and information, patient care and support, physical and daily living, and sexuality issues.
In this randomized controlled trial of 288 H/L survivors diagnosed with breast, prostate, or colorectal cancer, women assigned to a culturally tailored patient navigation program experienced a reduction in unmet needs compared with those who received standard patient navigation.
H/L men did not experience a change in unmet needs.
Theoretical Insights into Ultrafast Separation of Photogenerated Charges in a Push‐Pull Polarized Molecular Triad
Authors: Szychta Kamil , Martyka Mikołaj , Jankowska Joanna 
Published: November 2024

AbstractHerein, we propose a purely‐organic donor‐acceptor (D−A) molecular triad, with a light‐absorbing polarized molecular wire (PMW) used as a central linkage, as a proof of concept for the possible future applications of the D‐PMW−A arrangement in molecular photovoltaics. This work builds upon our earlier study on the PMW unit itself, which proved to be highly promising for the ultrafast photogeneration of free charge carriers. Quantum‐chemical calculations performed for the D‐PMW−A triad at a semi‐empirical level of theory reveal a large electric dipole moment of the system, and show strong charge‐transfer (CT) character of its lowest‐energy excited electronic states, including the
, which favours efficient dissociation of an exciton initially formed upon the absorption of light. The confirmation for this effect was found with nonadiabatic molecular dynamics simulations, revealing an ultrafast relaxation from higher, bright excited states to
, completed on a subpicosecond timescale. The architecture of the proposed molecular triad enables its electronic coupling to the surrounding environment through chemical bonds, or noncovalent stacking interactions, which might open way for synthesis of a new class of D‐PMW−A efficient molecular organic photovoltaic materials.
Terminal Sliding Mode Control of Microgrid Inverter Systems
Authors: Wang Zixin , Xiu Chunbo , Cheng Yi , Li Baoquan 
Published: November 2024

ABSTRACTTo enhance the power quality of microgrid inverters and reduce the influence of changes in inductance parameters and external disturbances on the direct power control of the inverter system, a terminal sliding mode control strategy with a variable exponential power reaching law has been proposed. The designed new reaching law comprises a variable exponential term and an enhanced power term. The variable exponential term contains an arctangent function, and the power term coefficient is replaced by a function about the sliding mode. Therefore, the convergence rate can be adaptively adjusted based on different stages of the system, ensuring a faster rate of convergence throughout the process of approaching the sliding mode surface. To weaken the effects of changes in inductance parameters, a power disturbance observer is designed to estimate the internal disturbances induced by the filtered inductance in the system. Subsequently, a sliding mode control law containing disturbance observations is derived. Moreover, a variable exponential terminal sliding surface is designed to adjust the convergence rate of system errors on the sliding surface in stages, thereby enhancing the control performance of the system. The simulation results show that the new reaching law has faster convergence rate and better dynamic performance. The convergence speed of the system error can be accelerated by the designed variable exponential terminal sliding surface. The sliding mode control strategy with the variable exponential power reaching law is applicable to the power control system of three‐phase inverters in microgrids, thereby significantly enhancing the dynamic performance and robustness of the system.
A New Three‐Port DC–DC Converter: Analysis, Design, and Verification for Hybrid Energy Systems
Authors: Malik Muhammad Zeeshan , Zhang Shiqing , Chen Guang , Ali Amjad 
Published: November 2024

ABSTRACTA research study on the three‐port DC–DC converters is done in this article. The proposed converter is a power electronic unit with a low‐voltage, high‐voltage, and battery port. The power of the input ports can be transferred to the output port simultaneously and individually. In this converter, the power can flow bidirectional. In other words, the battery can be charged not only by the low‐voltage port but also by the returned energy from the high‐voltage port. Hence, the proposed converter can operate in step‐up and step‐down modes. Continuous input current, the low voltage stress on semiconductors, and the low count of the devices are other advantages of the converter. These features and the benefits mentioned above make the proposed converter proper for hybrid energy systems. This converter is analyzed in continuous conduction mode, resulting in mathematical equations. To validate these theoretical analyses, a laboratory scale of the converter performs at 50 kHz, 200 W, and 115 V.
Leakage Current Suppression and Balance Control of Neutral Point Potential for Three‐Level Inverter
Authors: Meng Ningning , Min Yongzhi , Shi Zhilong 
Published: November 2024

ABSTRACTNonisolated three‐level inverter has the problem of leakage current and neutral‐point (NP) potential imbalance in photovoltaic grid‐connected system. Therefore, a new subregional vector‐optimized modulation strategy is proposed, which can be adopted to achieve leakage current suppression and NP potential balance control in full power factor and the range of full modulation ratio. First, a system model is established for the three‐level grid‐connected inverter to analyze the mechanism of leakage current and the factors affecting the NP potential. Aiming at the shortcomings of existing modulation strategies, the three‐level space vector modulation region is redivided, and different voltage vector preselection methods are used in different modulation regions, reduced computing power. In addition, controlling the balance of NP potential, the effect of dead zone effect on the leakage current is further analyzed and improved on the basis of the proposed strategy. Finally, the proposed strategy is compared with the traditional space vector pulse width modulation strategy. The experimental results show that the proposed control strategy suppresses the leakage current below 300 mA and can effectively control the NP potential shift and eliminate the midpoint potential fluctuation. Meanwhile, the control strategy is low in computation and fast in seeking the optimum.
A Compact Planar MIMO Inverted‐F Antenna (PIFA) for Sub‐6 GHz 5G Communication and IoT Wireless Networks Applications
Authors: Babu K. Vasu , Sree Gorre Naga Jyothi , Das Sudipta , Ali Wael , Islam Tanvir , EL Ghzaoui Mohammed 
Published: November 2024

ABSTRACTA compact eight‐port MIMO structure containing planar inverted‐F antennas (PIFAs) as radiating elements is designed for 5G cellular communication applications within the sub‐6 GHz band. The proposed antenna consists of four radiating elements that are placed at four corners on the same plane of geometry. The overall dimension of the ground plane is considered to be 59 mm × 120 mm to make it convenient for modern smart mobile handsets. Each radiating element has 2‐feeding plates, which are situated perpendicular to each other in orientation to make the arrangement cross‐polarized, which in turn exploits polarization diversity as well as spatial diversity among the combination of different radiating elements. The patches are structured by embedding rectangular slots in a meandered shape, and the ground plane is configured by introducing rectangular slots and narrow metallic strips. The prototype of the prescribed MIMO PIFA model has been fabricated and experimentally tested. It shows multi‐band operations (3.27–3.37, 4.16–4.35, 4.93–5.06, and 5.47–5.68 GHz) within the sub‐6 GHz spectrum. The isolation among various patches is observed within the range of −35 dB to −42 dB. The peak gain reaches around 8.1 dBi. The designed MIMO PIFA exhibits superior diversity performance by producing ECC ≤ 0.0006, DG ≈ 10 dB, CCL < 0.20 bits/Hz/s, and MEG ≤ −3 dB. Furthermore, the specific absorption rate (SAR) is evaluated according to the standard values of fat, skin, and muscle at 3.3 GHz. The prescribed model maintains acceptable SAR values for 1‐g and 10‐g tissues, which makes it suitable for smartphone applications.
Potter Cove's Heavyweights: Estimation of Species' Interaction Strength of an Antarctic Food Web
Authors: Rodriguez Iara Diamela , Saravia Leonardo Ariel 
Published: November 2024

ABSTRACTIn the West Antarctic Peninsula, global warming has led to severe alterations in community composition, species distribution, and abundance over the last decades. Understanding the complex interplay between structure and stability of marine food webs is crucial for assessing ecosystem resilience, particularly in the context of ongoing environmental changes. In this study, we estimate the interaction strength within the Potter Cove (South Shetland Islands, Antarctica) food web to elucidate the roles of species in its structure and functioning. We use these estimates to calculate food web stability in response to perturbations, conducting sequential extinctions to quantify the importance of individual species based on changes in stability and food web fragmentation. We explore connections between interaction strength and key topological properties of the food web. Our findings reveal an asymmetric distribution of interaction strengths, with a prevalence of weak interactions and a few strong ones. Species exerting greater influence within the food web displayed higher degree and trophic similarity but occupied lower trophic levels and displayed lower omnivory levels (e.g., macroalgae and detritus). Extinction simulations revealed the key role of certain species, particularly amphipods and the black rockcod Notothenia coriiceps, as their removal led to significant changes in food web stability and network fragmentation. This study highlights the importance of considering species interaction strengths in assessing the stability of polar marine ecosystems. These insights have crucial implications for guiding monitoring and conservation strategies aimed at preserving the integrity of Antarctic marine ecosystems.