bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessing Social Sustainability Efficiency in European Countries: Focusing on Health and Well‐Being
Authors: Chien Hsiu‐Fang , Lu Liang‐Chun , Chiu Shih‐Yung , Lin Tai‐Yu , Chiu Yung‐Ho 
Published: December 2024

ABSTRACTThis study investigates the challenges of achieving social sustainability efficiency in European countries, especially in health and well‐being, under sustainable development goal 3 amid demographic aging pressures. Using an innovative modified circular dynamic three‐stage systematic network data envelopment analysis model, this research evaluates the influence of social protection investments on healthcare and well‐being systems. The findings reveal that Denmark, Estonia, France, and Germany demonstrate optimal efficiency, while Lithuania, Luxembourg, the Netherlands, and Slovenia require strategic improvements, particularly in healthcare efficiency. Policy recommendations underscore the need for enhanced healthcare technology, occupational safety, and adaptive strategies to support social sustainability across 24 countries from 2016 to 2020. This approach offers a comprehensive efficiency framework and actionable insights to guide future policy development to address European healthcare efficiency gaps.
Ru Active Centers Incorporated on Ce‐MOFs as an Efficient Heterogeneous Catalyst for Oxidation of Alkylarenes to Carbonyls
Authors: Zhao Ruibi , Wang Zhixian , Sun Hao , Chen Guozhu , Zhao Huaiqing 
Published: December 2024

AbstractIn recent years, the construction of the carbonyl group which can be extensively found in various important chemicals have attracted great interest of researchers. In this study, a strategy of coordination is employed to synthesize Ru‐UiO‐66‐NH2 (Ce) with uniformly dispersed Ru ions in UiO‐66‐NH2 (Ce) MOFs as an efficiently heterogenous catalyst for the catalytic oxidation of benzyl sp3 C─H bond to the carbonyl group in water. The characterized results indicate that the active Ru centers were successfully incorporated via the coordination with the amino group in UiO‐66‐NH2 (Ce) MOFs. This strategy could furnish more catalytic active sites to improve the catalytic performance of Ru‐UiO‐66‐NH2 (Ce). A series of alkylarenes could be efficiently oxidized to ketones with Ru‐UiO‐66‐NH2 (Ce) catalyst under mild conditions. Furthermore, the catalyst's recyclability demonstrated that its catalytic performance remained robust, with no significant loss in the catalytic activity observed after being recycled seven times.
Conductive Modification of Activated Carbon Fiber Cloths via Electrophoretic Deposition for Cathode in Lithium‐Ion Capacitor
Authors: Chen Xing , Yan Changyu , Chen Xue , Yang Cheng , Liu Yong , Liu Shujing , Song Chaoyu , Xin Zhiling , Zai Jiantao , Xu Miao 
Published: December 2024

AbstractWith the growing demand for high performance energy storage devices, the advanced manufacturing technology of electrodes, which is a crucial component, has become increasingly essential in academic research and industrial applications. Activated carbon fiber cloth (ACFC) is a promising candidate for lithium‐ion capacitor (LIC) electrodes due to its abundant internal space and pores. However, the wider application of ACFC is restricted by its inferior conductivity. The conventional coating process is costly in terms of both materials and time and is only applicable to surface treatment with limitations in treating shaped substrate such as ACFCs. To overcome the applications obstacles of ACFC in batteries and capacitors, we propose a novel strategy for modification that utilizes electrophoretic deposition (EPD) to deposit Super P onto the surface, thus enhancing its conductivity. After being deposited for 10 min at 80 V, the modified ACFC exhibited higher conductivity. When matched with Si@C anode, the assembled LIC demonstrates excellent initial specific areal capacitance (710 mF cm−2) and cycling retention, with 76.92% remaining after 100 cycles at a current density of 7 mA cm−2. When matched with Si@C anode, the assembled LIC demonstrates excellent initial specific areal capacitance (26.91 F g−1) and cycling retention, with 85.21% remaining after 100 cycles at a current density of 0.2 A g−1. This work showcases the potential of EPD technology in the realm of electrode preparation and offers insights for electrode manufacture in other systems.
Mixed Metal Oxide Heterojunction for High‐Performance Self‐Powered Ultraviolet Photodetection
Authors: Sun Simin , Li Wenhui , Zhang Yuan , Gao Qiyue , Zhang Nana , Qin Yuyang , Feng Wei 
Published: December 2024

AbstractThe field of photoelectrochemical‐type (PEC) ultraviolet (UV) photodetectors has witnessed swift progression due to their facile fabrication processes and self‐powered function. The realization of high‐performance and self‐powered PEC UV photodetectors is attractive and challenging. In this study, the application of ZnAl mixed metal oxide (MMO) heterojunctions in self‐powered PEC UV photodetectors is introduced for the first time. The MMO heterojunctions are composed of ZnO and ZnAl2O4, which provide a suitable band structure for accelerating the photogenerated carrier separation and transport, boosting UV photodetection. Irradiation of the self‐powered MMO PEC UV photodetectors with UV light (365 nm) results in a high responsivity of 46.82 mA W−1 and a fast response time of 18/35 ms. An impressive UV/visible rejection ratio of 1088.8 and excellent multi‐cycle stability are demonstrated, exceeding the most recently reported PEC UV photodetectors. Moreover, the MMO PEC UV photodetectors possess underwater optical communication capability, confirming promising potential for underwater optoelectronic devices. This study provides a new perspective on the development of high‐performance PEC UV photodetectors.
Transcending Systems Thinking: Critical Systems Integration and What's Love Got to Do With It
Authors: Klein Louis 
Published: December 2024

ABSTRACTSystems thinking is a promise of wholeness and agency. It appears as the right approach to meet the challenges of the Anthropocene. Yet, to keep its promise, systems thinking needs to critically review itself, the wholeness it integrates and the sense of agency it informs and forms. Transcending systems thinking is a continuous process of critical systems integration. Since the 1980s, this process of further integrating systems thinking in the mirror of complex (organisational) practice has been Mike Jacksons research agenda. Today, in the light of the demands of systems change vocalised by a young generation of activists and campaigners but more so in the mirror of research in metamorphic transformation, a next chapter of critical systems integration is due. Widening the gaze and revisiting its philosophical foundations, critical systems integration dissolves distinctions in a quest for meaning and purpose and transcends in a metamodern turn the axiological struggle of the critical school. Critical systems integration embraces a wider range of lived experiences allowing itself to include the formerly excluded. It finds its confluence in a shared understanding growing from co‐reflected lived experiences. In the Tamkeen experience of metamorphic transformation, systems thinking mirrors itself and the challenges of the generation systems change growing out of itself, from itself, into itself; and finally, it needs to answer the ultimate critical question: What's love got to do with it?
Resolving the early‐diverging clades of Loasaceae subfam. Loasoideae – Segregating the new genus Prosa from the Atacama Desert genus Huidobria
Authors: Acuña‐Castillo Rafael , Böhnert Tim , Jeiter Julius , Weigend Maximilian 
Published: December 2024

AbstractHuidobria, an enigmatic genus in the Loasaceae family, has long puzzled botanists due to its unclear phylogenetic position and morphological distinctiveness within Loasaceae. Focusing on its two species, H. chilensis and H. fruticosa, we employed the Angiosperms353 target probe set alongside a comprehensive morphological evaluation to resolve their taxonomic status. Our analyses revealed significant divergence in seed, leaf, and flower morphology, supported by phylogenetic data indicating long independent evolutionary histories. Huidobria fruticosa, in particular, shows no close relationship to H. chilensis or other extant Loasaceae genera. Consequently, we propose the segregation of H. fruticosa into the new genus Prosa, together with a comprehensive taxonomic revision of both species. A phylogenetic tree encompassing all genera of Loasaceae illuminates the evolutionary relationships within the family.
Correlators for pseudo Hermitian systems
Authors: Bai Yao , Feng Ting-Long , Kim Suro , Lee Cheng-Yang , Liu Lei-Hua , Zhao Wangping , Zhou Siyi 
Published: December 2024

Abstract
Pseudo-Hermitian system is a class of non-Hermitian system with Hamiltonian satisfying the condition η−1H†η = H. We develop the in-in and Schwinger Keldysh formalism to calculate cosmological correlators for pseudo-Hermitian systems. We study a model consists of massive symplectic fermions coupled to the primordial curvature perturbation. The three-point function for the primordial curvature perturbation is computed up to one-loop and compared to earlier work where the loop correction comes from a massive scalar boson. The two results differ by a minus sign. Therefore, the one loop correction to the three-point function cannot be used to distinguished scalar bosons and symplectic fermions. To conclude, we discuss possibilities where the scalar bosons and symplectic fermions may be distinguished.
MTSS1: beyond the integration of actin and membrane dynamics
Authors: Matskova Liudmila , Zheng Shixing , Kashuba Elena , Ernberg Ingemar , Aspenström Pontus 
Published: December 2024

AbstractMTSS1 is a ubiquitously expressed intracellular protein known mainly for its involvement in basic cellular processes, such as the regulation of actin organization and membrane architecture. MTSS1 has attracted much attention for its role as a tumor suppressor, being absent or expressed at reduced levels in advanced and metastasizing cancers. Occasionally, MTSS1 is, instead, upregulated in metastasis and, in some cases, even in primary tumors. In addition to these well-established functions of MTSS1 linked to its I-BAR- and WH2-domains, the protein is involved in modulating cell–cell contacts, cell differentiation, lipid metabolism, and vesicle formation and acts as a scaffolding protein for several E3 ubiquitin ligases. MTSS1 is classified as a housekeeping protein and is never mutated despite the several pathologic phenotypes linked to its dysregulation. Despite MTSS1’s involvement in fundamental signaling pathways, MTSS1 gene ablation is not ubiquitously lethal, although it affects embryonic development. Due to MTSS1´s involvement in many seemingly disparate processes, with many cases lacking mechanistic explanations, we found it timely to review the recent data on MTSS1’s role at the cellular level, as well as in health and disease, to direct further studies on this interesting multifunctional protein.
Shared and distinct changes in the molecular cargo of extracellular vesicles in different neurodegenerative diseases
Authors: Wiersema Anna F. , Rennenberg Alyssa , Smith Grace , Varderidou-Minasian Suzy , Pasterkamp R. Jeroen 
Published: December 2024

AbstractNeurodegenerative disorders such as Alzheimer’s disease (AD), amyotrophic lateral sclerosis (ALS) and Parkinson’s disease (PD) affect millions of people worldwide. Curative treatment for these neurodegenerative disorders is still lacking and therefore a further understanding of their cause and progression is urgently needed. Extracellular vesicles (EVs) are nanosized vesicles loaded with cargo, such as proteins and miRNAs, that are released by cells and play an important role in intercellular communication. Intercellular communication through EVs can contribute to the spread of pathological proteins, such as amyloid-beta and tau, or cause pathogenesis through other mechanisms. In addition, EVs may serve as potential biomarkers for diagnosis and for monitoring disease progression. In this review, we summarize and discuss recent advances in our understanding of the role of EVs in AD, ALS an PD with an emphasis on dysregulated cargo in each disease. We highlight shared dysregulated cargo between these diseases, discuss underlying pathways, and outline future implications for therapeutic strategies.
Arbeitsbelastung und psychische Gesundheit von Pflegekräften in Deutschland während der COVID-19-Pandemie – Ein Scoping-Review
Authors: Arndt Dagmar , Hering Thomas 
Published: December 2024

Zusammenfassung

Hintergrund
Im März 2023 existierte für Deutschland keine zusammenfassende Übersichtarbeit zu Arbeitsbelastung, Ressourcen, Beanspruchungsfolgen in der COVID-19-Pandemie für Pflegefachkräfte. Vor dem Hintergrund länderspezifischer Unterschiede hinsichtlich Pandemieverlauf/-management und Organisation des Gesundheitswesens soll eine gesonderte Betrachtung von Daten aus Deutschland erfolgen.

Methode
Eine systematische Datenbankrecherche (PubMed/Medline, PsycINFO) brachte 50 relevante Studien, die Eingang in das Scoping-Review fanden.

Ergebnisse
Die Studien basieren auf Querschnittdesigns, stammen zumeist aus dem Setting Klinik und dem ersten Pandemiejahr. Häufig untersuchte Belastungsfaktoren waren Arbeitsintensivierung, fehlende Schutzausrüstung, schnell wechselnde Regelungen, Kontakt zu COVID-19-Patienten, pandemiebezogene Sorgen/Ängste. Pandemiephasen- und settingspezifische Belastungskaskaden wurden deutlich. Häufig untersuchte psychische Beanspruchungen (u. a. Stresserleben, Angst, Depressivität, Burn-out, Berufs‑/Arbeitsplatzwechselabsichten) waren in Gruppen mit ungünstigeren Belastungswerten höher. Pflegende berichteten zumeist ungünstigere Merkmalsausprägungen als Mediziner. Soziale Unterstützung, Belohnung/Wertschätzung, Humor, Resilienz und Kohärenzgefühl erwiesen sich als Ressourcen.

Schlussfolgerung
In Vorbereitung auf weitere Pandemien und Krisen sollten präpandemisch vorliegende Belastungsfaktoren durch gezielte Maßnahmen abgebaut und relevante Ressourcen gestärkt werden. Pandemiespezifische Belastungsfaktoren sollten systematisch reflektiert, organisationsübergreifend Lösungen erarbeitet werden. Längsschnittstudien unter Nutzung validierter Instrumente sowie Interventionsstudien sollten zukünftig in den Fokus der Forschungsförderung fallen.
Safety of PSMA radioligand therapy in mCRPC patients with preexisting moderate to severe thrombocytopenia
Authors: Bastian Moritz B. , Sieben Maike , Blickle Arne , Burgard Caroline , Speicher Tilman , Bartholomä Mark , Schaefer-Schuler Andrea , Maus Stephan , Ezziddin Samer , Rosar Florian 
Published: December 2024

Abstract

Purpose
Aim of this study was to analyze the safety of prostate-specific membrane antigen radioligand therapy (PSMA-RLT) in patients with metastatic castration-resistant prostate cancer (mCRPC) with preexisting moderate to severe thrombocytopenia (CTCAE ≥ 2).

Materials and methods
Seventeen mCRPC patients with preexisting thrombocytopenia (platelet count < 75 × 109/L) were included in this study. Patients received a median of 3 cycles of [177Lu]Lu-PSMA-617 (range 1–6). The course of platelet cell count was closely monitored within and after the PSMA-RLT and analyzed statistically and according to CTCAE.

Results
No significant difference in platelet counts was observed between baseline and follow-up after each PSMA-RLT cycle: first cycle (54.18 ± 16.07 at baseline vs. 59.65 ± 39.16 at follow up [in × 109/L], p=  0.834), second cycle (58.56 ± 16.43 vs. 107.1 ± 56.44, p = 0.203), and third cycle (60.38 ± 16.57 vs. 132.1 ± 80.43, p = 0.148), respectively. Similarly, baseline and end of treatment values, irrespective of the number of administered cycles, did not reveal a significant difference (54.18 ± 16.07 vs. 72.06 ± 71.9, p = 0.741). After the end of therapy, irrespective of the number of administered cycles, 29.4% of patients remained stable in terms of CTCAE scoring, 41.2% changed to a higher score and 29.4% improved to a lower score. We observed no critical bleeding events due to thrombocytopenia.

Conclusion
Despite the common consideration of marked preexisting thrombocytopenia as a contraindication for RLT, this study indicates feasibility of PSMA-RLT in patients with preexisting thrombocytopenia of grade ≥ 2, as in our preliminary experience, there was no RLT-induced significant deterioration of platelet cell count. Thus, patients with thrombocytopenia should not be categorically excluded from receiving PSMA-RLT.
Vector-based navigation in desert ants: the significance of path-integration vectors
Authors: Voegeli Beatrice , Sommer Stefan , Knaden Markus , Wehner Rüdiger 
Published: December 2024

AbstractIn the longstanding discussion of whether insects, especially central place foragers such as bees and ants, use metric representations of their landmark surroundings (so-called “cognitive maps”), the ability to find novel shortcuts between familiar locations has been considered one of the most decisive proofs for the use of such maps. Here we show by channel-based field experiments that desert ants Cataglyphis can travel such shortcuts between locations (defined by memorized goal vectors) just on the basis of path integration. When trained to visit two spatially separated feeders A and B they later travel the hitherto novel route A→B. This behavior may originate from the interaction of goal vectors retrieved from long-term memory and the current vector computed by the continuously running path integrator. Based on former experiments, we further argue that path integration is a necessary requirement also for acquiring landmark information (in form of learned goal-directed views). This emphasizes the paramount importance of path integration in these central place foragers. Finally we hypothesize that the ant’s overall system of navigation consists in the optimal combination of path-integration vectors and view-based vectors, and thus handles and uses vectorial information without the need of constructing a “vector map”, in which vectors are linked to known places in the environment others than to the origin of all journeys, the nest.
Megameatus intact prepuce: a systematic review of surgical techniques and long-term outcomes
Authors: Elawad Abubakr , Haroon Ahmed , Ahmad Jamil , Alsbeti Jude , Cherigui Sami , Arar Seem , Chandrasekharam V. V. S. , Abbas Tariq O. 
Published: December 2024

AbstractMegameatus intact prepuce (MIP) presents with diverse phenotypes that complicate the management of this rare but complex hypospadias variant. Current data on optimal treatment methods and patient outcomes are sparse, unintegrated, and therefore challenging to implement clinically. A comprehensive systematic review of the existing literature on MIP was conducted according to PRISMA guidelines. Electronic databases including PubMed, Embase, and Scopus were searched for relevant articles published up to [2024]. Key aims were to assess the safety and efficacy of different surgical interventions, and synthesize corresponding outcomes reported in the literature. The search yielded 18 articles meeting the inclusion criteria, representing a total of 524 enrolled patients across multiple geographic regions. Diagnosis of MIP typically involves clinical examination, imaging studies, and urological evaluation. Surgical management options included preputial reconstruction, urethroplasty, and meatal advancement with glanuloplasty. Reported outcomes varied, with success rates ranging from [77.1–100%]. Long-term follow-up data on functional and cosmetic outcomes were limited. Megameatus intact prepuce presents diagnostic and management challenges due to low prevalence and variable presentation. This systematic review presents a current understanding of MIP diagnosis, surgical techniques, and patient outcomes. Future studies should assess the long-term functional outcomes of different surgical approaches, and investigate the underlying genetic and environmental factors contributing to the diverse clinical manifestations of MIP.
Identification of isoAsp7-Aβ as a major Aβ variant in Alzheimer’s disease, dementia with Lewy bodies and vascular dementia
Authors: Schrempel Sarah , Kottwitz Anna Katharina , Piechotta Anke , Gnoth Kathrin , Büschgens Luca , Hartlage-Rübsamen Maike , Morawski Markus , Schenk Mathias , Kleinschmidt Martin , Serrano Geidy E. , Beach Thomas G. , Rostagno Agueda , Ghiso Jorge , Heneka Michael T. , Walter Jochen , Wirths Oliver , Schilling Stephan , Roßner Steffen 
Published: December 2024

AbstractThe formation of amyloid-β (Aβ) aggregates in brain is a neuropathological hallmark of Alzheimer’s disease (AD). However, there is mounting evidence that Aβ also plays a pathogenic role in other types of dementia and that specific post-translational Aβ modifications contribute to its pathogenic profile. The objective of this study was to test the hypothesis that distinct types of dementia are characterized by specific patterns of post-translationally modified Aβ variants. We conducted a comparative analysis and quantified Aβ as well as Aβ with pyroglutamate (pGlu3-Aβ and pGlu11-Aβ), N-truncation (Aβ(4-X)), isoaspartate racemization (isoAsp7-Aβ and isoAsp27-Aβ), phosphorylation (pSer8-Aβ and pSer26-Aβ) or nitration (3NTyr10-Aβ) modification in post mortem human brain tissue from non-demented control subjects in comparison to tissue classified as pre-symptomatic AD (Pre-AD), AD, dementia with Lewy bodies and vascular dementia. Aβ modification-specific immunohistochemical labelings of brain sections from the posterior superior temporal gyrus were examined by machine learning-based segmentation protocols and immunoassay analyses in brain tissue after sequential Aβ extraction were carried out. Our findings revealed that AD cases displayed the highest concentrations of all Aβ variants followed by dementia with Lewy bodies, Pre-AD, vascular dementia and non-demented controls. With both analytical methods, we identified the isoAsp7-Aβ variant as a highly abundant Aβ form in all clinical conditions, followed by Aβ(4-X), pGlu3-Aβ, pGlu11-Aβ and pSer8-Aβ. These Aβ variants were detected in distinct plaque types of compact, coarse-grained, cored and diffuse morphologies and, with varying frequencies, in cerebral blood vessels. The 3NTyr10-Aβ, pSer26-Aβ and isoAsp27-Aβ variants were not found to be present in Aβ plaques but were detected intraneuronally. There was a strong positive correlation between isoAsp7-Aβ and Thal phase and a moderate negative correlation between isoAsp7-Aβ and performance on the Mini Mental State Examination. Furthermore, the abundance of all Aβ variants was highest in APOE 3/4 carriers. In aggregation assays, the isoAsp7-Aβ, pGlu3-Aβ and pGlu11-Aβ variants showed instant fibril formation without lag phase, whereas Aβ(4-X), pSer26-Aβ and isoAsp27-Aβ did not form fibrils. We conclude that targeting Aβ post-translational modifications, and in particular the highly abundant isoAsp7-Aβ variant, might be considered for diagnostic and therapeutic approaches in different types of dementia. Hence, our findings might have implications for current antibody-based therapies of AD.