bluuebunny/crossref_metadata_2025_split huggingface dataset:
Stability Analysis and Reinforcement Treatment of Open Pit Slope
Authors: Liu Yunqiu , Wang Xiaofei , Gao Jiaxing 
Published: June 2019

Abstract
The construction of mine surface facilities shall be carried out according to the scope of mining rights and ease of use. The underground mining of Shirengou Iron Mine uses filling method mining, and the filling station needs to be built on the surface. According to the design, it is constructed near the open pit. Based on the protection of the filling station system, the stability analysis of the open slope is needed. The failure mode of iron ore open slope is circular arc sliding failure mode. The calculation model of the stability analysis is calculated by the residual thrust method. The maximum residual thrust of the I-I section is 128.9 tons/meter, and the maximum residual thrust of the II-II section is 75.39 tons/meter. According to the calculation results, the safety measures such as slope dressing and masonry retaining wall are carried out on the open slope, and the grouting prestressed anchor cable is selected to reinforce the slope. The anchor cables are connected by reinforced concrete frame and beam, and the concrete is used. The beam acts as an anchor pier. In order to effectively consolidate the slope stability, the grouting method is combined to effectively treat the slope. After a series of slope reinforcement measures, the stability of the open slope and the safety of the filling station can be guaranteed.
Research Progress on Self-Healing and Repairing Technology of Asphalt Mixture Crack
Authors: Hui Jia , Gu Yunhui , Wang Tong , Jiang Ruinan , Zhu Baolin 
Published: June 2019

Abstract
The latest research results at home and abroad have comprehensively analyzed the self-healing and repairing technology of asphalt mixture, and introduced the self-healing mechanism of asphalt and self-healing behavior of asphalt. Active and passive healing methods are mainly discussed. Both methods can effectively enhance the healing properties of asphalt materials and achieve the purpose of repairing cracks and looseness of asphalt concrete pavement. The development of self-healing asphalt concrete technology at home and abroad is expounded, and the application significance and application prospect of the technology are analyzed. The conclusion is that the environmental and social benefits of self-healing asphalt concrete technology are outstanding, and the promotion is of great significance and good development prospects.
The Dynamic Mechanics Behavior on Triaxial Compression of the Recycled Aggregate Concrete
Authors: He Z. J. , Ding M. J. 
Published: June 2019

Abstract
The tests under triaxial compression states were conducted on recycled aggregate concrete (RAC) by different stress ratios (-0.1: -0.1: -1; -0.1: -0.25: -1; -0.1: -0.5: -1; -0.1: -0.75: -1; -0.1: -1: -1) at the strain rates of 10-5/s, 10-4/s, 10-3/s, and 10-2/s. This study was accomplished in the servo-hydraulic multi-axial testing system. The experimental phenomena and failure modes of recycled aggregate concrete under triaxial compression are described, the results of triaxial compressive strength of recycled aggregate concrete are presented, the effects of the strain rate and stress ratio on the triaxial compressive strength of recycled aggregate concrete are studied. This paper built a new dynamic strength criterion. The strength criterion describes the characteristics of structural RAC at different stress ratios and strain rates. The feature of the model is that it can consider the influence of strain rates.
Analysis’s Research Status of Reinforcement Technology of PP-Bands in Masonry Structures
Authors: Zhou Qiang , Min Quanhuan , Wu Shuang 
Published: June 2019

Abstract
Reinforcement with polypropylene bands is a newly arisen seismic technique. it can effectively improve the ultimate shear and flexural capacity and seismic performance of the structure, sudden collapse of whole structure can also be avoided, so it is especially suitable for the seismic reinforcement of rural masonry structures. In recent years, it has been gradually applied in the reinforcement and restoration of masonry structures. Based on the latest development of research, the influence of reinforcement with polypropylene bands (pp-bands) on the shear, flexural and seismic behavior of masonry structure were systematically introduced. The influence of the main reinforcement parameters such as mesh size, grid layout direction, connection mode, connection strength and mortar layer on the reinforcement effect were summarized. Deficiency of the current research and the key problems that need to be solved were pointed out. Through the study on research status of reinforcement technology of pp-bands in masonry structures, references for further research on the strengthening technology of pp-bands and the seismic reinforcement of rural masonry buildings in China were given.
Influence of Shield Propulsion on Longitudinal Soil Mass Near Subway Structure
Authors: Zhang Zhaoran , Guo Yixian , Jiao Weigang , Tong Wenjing 
Published: June 2019

Abstract
Metro construction has important significance to the safety of the structure, based on a line existing Beijing subway, with air shaft and station structure as the background, research on soil displacement near the existing structure. The results show that: (1)The shield to the main structure from about 28.8m-7.2m (except for the shield at the center line testing point), the displacement and the shield is the same direction, the displacement changes generally decrease from the surface to the deep level, the variation is in the range of 1-5mm, with a linear distribution; (2) The displacement direction is as same as shield direction from 7.2m-3.6m, the displacement increases continuously is in the range of 5-15mm, the displacement accord with normal distribution; (3) 1 times diameter range and the shield to the existing structure of 7.2m-3.6m range should be regarded as significant influence area in the process of shield construction. The displacement of soil increases with the approach of shield, the maximum displacement point appears at the center of shield or above the top of shield of 1m. The above results can provide reference for shield driving parameters.
Application and Effect of Underground Magnetic Fluid Detection Technology to Detect Groundwater of Highway Slope
Authors: Yang Chao , Wang Kai , Cao Yunjiang 
Published: June 2019

Abstract
The dynamic information such as water level, supply source and motion direction of groundwater in slope engineering have an important influence on the selection of water drainage project. It is important to quickly and effectively ascertain the groundwater information of slope engineering. The underground magnetic fluid detection technology uses the groundwater flow system to continuously cut the magnetic force lines in the geomagnetic field to form the underground magnetic fluid and then generate induced electromagnetic fields. The dynamic information of groundwater can be detected quickly and efficiently by testing the electromagnetic field. The application results of groundwater detection technology in Shang-San Expressway in Zhejiang province to K290 + 400 slope show that: the results of exploration are basically consistent with the results of underground magnetic fluid detection; and groundwater distribution of slope which is tested by underground magnetic fluid detection technology is reliable. The underground magnetic fluid detection technology provides a quick and effective means for groundwater exploration of slope engineering.
A Nation of Immigrants?
Authors: Minich Julie Avril 
Published: June 2019

AbstractWith US immigration policy seeming ever more brutal with each new headline, it becomes increasingly tempting to advocate for the rights of migrants and asylum seekers by presenting the current situation as extraordinary and questioning the legitimacy of the Trump administration’s border enforcement tactics. Jay Timothy Dolmage, Katherine Benton-Cohen, and Beth Lew-Williams, however, show that the contemporary moment is far from exceptional; rather, immigration restriction in North America has long mobilized exclusionary nativist logics and shifting constructions of legality. Timely without being ripped from the headlines, their latest books offer much-needed historical context for a current humanitarian crisis along with important lessons from previous crises.
Precise modelling and interpretation of bioactivities of ligands targeting G protein-coupled receptors
Authors: Wu Jiansheng , Liu Ben , Chan Wallace K B , Wu Weijian , Pang Tao , Hu Haifeng , Yan Shancheng , Ke Xiaoyan , Zhang Yang 
Published: June 2019

AbstractMotivationAccurate prediction and interpretation of ligand bioactivities are essential for virtual screening and drug discovery. Unfortunately, many important drug targets lack experimental data about the ligand bioactivities; this is particularly true for G protein-coupled receptors (GPCRs), which account for the targets of about a third of drugs currently on the market. Computational approaches with the potential of precise assessment of ligand bioactivities and determination of key substructural features which determine ligand bioactivities are needed to address this issue.ResultsA new method, SED, was proposed to predict ligand bioactivities and to recognize key substructures associated with GPCRs through the coupling of screening for Lasso of long extended-connectivity fingerprints (ECFPs) with deep neural network training. The SED pipeline contains three successive steps: (i) representation of long ECFPs for ligand molecules, (ii) feature selection by screening for Lasso of ECFPs and (iii) bioactivity prediction through a deep neural network regression model. The method was examined on a set of 16 representative GPCRs that cover most subfamilies of human GPCRs, where each has 300–5000 ligand associations. The results show that SED achieves excellent performance in modelling ligand bioactivities, especially for those in the GPCR datasets without sufficient ligand associations, where SED improved the baseline predictors by 12% in correlation coefficient (r2) and 19% in root mean square error. Detail data analyses suggest that the major advantage of SED lies on its ability to detect substructures from long ECFPs which significantly improves the predictive performance.Availability and implementationThe source code and datasets of SED are freely available at https://zhanglab.ccmb.med.umich.edu/SED/.Supplementary informationSupplementary data are available at Bioinformatics online.
CoCoScore: context-aware co-occurrence scoring for text mining applications using distant supervision
Authors: Junge Alexander , Jensen Lars Juhl 
Published: June 2019

Abstract

Motivation
Information extraction by mining the scientific literature is key to uncovering relations between biomedical entities. Most existing approaches based on natural language processing extract relations from single sentence-level co-mentions, ignoring co-occurrence statistics over the whole corpus. Existing approaches counting entity co-occurrences ignore the textual context of each co-occurrence.

Results
We propose a novel corpus-wide co-occurrence scoring approach to relation extraction that takes the textual context of each co-mention into account. Our method, called CoCoScore, scores the certainty of stating an association for each sentence that co-mentions two entities. CoCoScore is trained using distant supervision based on a gold-standard set of associations between entities of interest. Instead of requiring a manually annotated training corpus, co-mentions are labeled as positives/negatives according to their presence/absence in the gold standard. We show that CoCoScore outperforms previous approaches in identifying human disease–gene and tissue–gene associations as well as in identifying physical and functional protein–protein associations in different species. CoCoScore is a versatile text mining tool to uncover pairwise associations via co-occurrence mining, within and beyond biomedical applications.

Availability and implementation
CoCoScore is available at: https://github.com/JungeAlexander/cocoscore.

Supplementary information
Supplementary data are available at Bioinformatics online.
Polyamine-stimulation of arsenic-transformed keratinocytes
Authors: Alexander Eric T , Mariner Kelsey , Borodyanskaya Yelizaveta , Minton Allyson , Gilmour Susan K 
Published: June 2019

Abstract
Tumor promotion is strongly associated with inflammation and increased polyamine levels. Our understanding of relevant mechanisms responsible for arsenic-induced cancer remains limited. Previous studies suggest that arsenic targets and dysregulates stem cell populations that remain dormant in the skin until promoted to be recruited out of the bulge stem cell region, thus giving rise to skin tumors. In this study, we explored a possible mechanism by which increased keratinocyte polyamine biosynthesis promotes tumorsphere formation and invasiveness of arsenic-transformed HaCaT keratinocytes (As-HaCaT). Unlike parental HaCaT cells, As-HaCaT cells were tumorigenic in athymic nude mice, and the CD45negative epithelial tumor cells had enriched expression of Toll-Like Receptor 4 (TLR4), CD34 and CXCR4 as did As-HaCaT tumorsphere cultures compared to As-HaCaT monolayer cultures. Ornithine decarboxylase (ODC) overexpressing keratinocytes (Ker/ODC) release increased levels of the alarmin high mobility group box 1 (HMGB1). Ker/ODC conditioned medium (CM) stimulated As-HaCaT but not parental HaCaT tumorsphere formation, and this was inhibited by glycyrrhizin, an inhibitor of HMGB1, and by TAK242, an inhibitor of the HMGB1 receptor TLR4. Compared to parental HaCaT cells, As-HaCaT cells demonstrated greater invasiveness across a Matrigel-coated filter using either fibroblast CM or SDF-1α as chemoattractants. Addition of Ker/ODC CM or HMGB1 dramatically increased As-HaCaT invasiveness. Glycyrrhizin and TAK242 inhibited this Ker/ODC CM-stimulated invasion of As-HaCaT cells but not HaCaT cells. These results show that polyamine-dependent release of HMGB1 promotes the expansion of stem cell-like subpopulations in arsenic-transformed keratinocytes while also increasing their invasiveness, suggesting that polyamines may be a potential therapeutic target for the prevention and treatment of arsenic-initiated skin cancers.
STDP Forms Associations between Memory Traces in Networks of Spiking Neurons
Authors: Pokorny Christoph , Ison Matias J , Rao Arjun , Legenstein Robert , Papadimitriou Christos , Maass Wolfgang 
Published: June 2019

Abstract
Memory traces and associations between them are fundamental for cognitive brain function. Neuron recordings suggest that distributed assemblies of neurons in the brain serve as memory traces for spatial information, real-world items, and concepts. However, there is conflicting evidence regarding neural codes for associated memory traces. Some studies suggest the emergence of overlaps between assemblies during an association, while others suggest that the assemblies themselves remain largely unchanged and new assemblies emerge as neural codes for associated memory items. Here we study the emergence of neural codes for associated memory items in a generic computational model of recurrent networks of spiking neurons with a data-constrained rule for spike-timing-dependent plasticity. The model depends critically on 2 parameters, which control the excitability of neurons and the scale of initial synaptic weights. By modifying these 2 parameters, the model can reproduce both experimental data from the human brain on the fast formation of associations through emergent overlaps between assemblies, and rodent data where new neurons are recruited to encode the associated memories. Hence, our findings suggest that the brain can use both of these 2 neural codes for associations, and dynamically switch between them during consolidation.
Immune Reconstitution Inflammatory Syndrome as a Posttransplantation Complication in Primary Immunodeficiency With Disseminated Mycobacterium avium
Authors: Manion Maura , Dimitrova Dimana , Pei Luxin , Gea-Banacloche Juan , Zelazny Adrian , Lisco Andrea , Zerbe Christa , Freeman Alexandra F , Holland Steven M , Kanakry Christopher G , Kanakry Jennifer A , Sereti Irini 
Published: June 2019

Abstract
Patients with primary immunodeficiencies undergoing allogeneic hematopoietic cell transplantation (HCT) for difficult-to-control infections can experience immune reconstitution inflammatory syndrome (IRIS) following engraftment. In 3 patients with post-HCT IRIS related to mycobacterial infection, in vitro data demonstrate the emergence of pathogen-specific immune responses and a concomitant rise in plasma inflammatory markers.
Photosynthesis and Survival of Young Carpotroche brasiliensis Endl. (Achariaceae) Plants Subjected to Flooding
Authors: Queiroz-Alves Laize , Leal Adrielle , Dalmolin Ândrea Carla , Schaffer Bruce , Mielke Marcelo Schramm 
Published: June 2019

Abstract
Carpotroche brasiliensis is a native tree of the Brazilian Atlantic Forest with potential economic value for cultivation in agroforestry systems. We conducted an experiment to determine the photosynthetic and survival responses of young C. brasiliensis plants to electrochemical changes in flooded soils as an indication of their flood tolerance and potential for cultivation in flood-prone areas. Soil flooding decreases the reduction–oxidation potential (redox) potential (Eh), pH, and electrical conductivity (Ec) of the soil, with subsequent recovery of the pH and Ec. Decreases in Eh negatively affect net photosynthesis (A). In flooded soil, decreased A was associated with decreased stomatal conductance (gs) and after 21 days was also associated with decreases in the instantaneous carboxylation efficiency (A/Ci) and potential quantum yield of photosystem II (Fv/Fm). Although flooded C. brasiliensis seedlings developed morphological structures known to increase flood tolerance, this was not enough to prevent severe signs of flooding stress. After 21 days of flooding, flooded plants were unflooded, and 17 days after plants were removed from flood, 90 percent of the unflooded plants died. Our results demonstrate that young plants of C. brasiliensis are suitable for planting in agroforestry systems only in areas with well-drained soils.
Enrichment of G4DNA and a Large Inverted Repeat Coincide in the Mitochondrial Genomes of Termitomyces
Authors: Nieuwenhuis Mathijs , van de Peppel Lennart J J , Bakker Freek T , Zwaan Bas J , Aanen Duur K 
Published: June 2019

AbstractMitochondria retain their own genome, a hallmark of their bacterial ancestry. Mitochondrial genomes (mtDNA) are highly diverse in size, shape, and structure, despite their conserved function across most eukaryotes. Exploring extreme cases of mtDNA architecture can yield important information on fundamental aspects of genome biology. We discovered that the mitochondrial genomes of a basidiomycete fungus (Termitomyces spp.) contain an inverted repeat (IR), a duplicated region half the size of the complete genome. In addition, we found an abundance of sequences capable of forming G-quadruplexes (G4DNA); structures that can disrupt the double helical formation of DNA. G4DNA is implicated in replication fork stalling, double-stranded breaks, altered gene expression, recombination, and other effects. To determine whether this occurrence of IR and G4DNA was correlated within the genus Termitomyces, we reconstructed the mitochondrial genomes of 11 additional species including representatives of several closely related genera. We show that the mtDNA of all sampled species of Termitomyces and its sister group, represented by the species Tephrocybe rancida and Blastosporella zonata, are characterized by a large IR and enrichment of G4DNA. To determine whether high mitochondrial G4DNA content is common in fungi, we conducted the first broad survey of G4DNA content in fungal mtDNA, revealing it to be a highly variable trait. The results of this study provide important direction for future research on the function and evolution of G4DNA and organellar IRs.
Deleterious Mutation Accumulation in Arabidopsis thaliana Pollen Genes: A Role for a Recent Relaxation of Selection
Authors: Harrison Mark C , Mallon Eamonn B , Twell Dave , Hammond Robert L 
Published: June 2019

AbstractIn many studies, sex-related genes have been found to evolve rapidly. We therefore expect plant pollen genes to evolve faster than sporophytic genes. In addition, pollen genes are expressed as haploids which can itself facilitate rapid evolution because recessive advantageous and deleterious alleles are not masked by dominant alleles. However, this mechanism is less straightforward to apply in the model plant species Arabidopsis thaliana. For 1 Myr, A. thaliana has been self-compatible, a life history switch that has caused: a reduction in pollen competition, increased homozygosity, and a dilution of masking in diploid expressed, sporophytic genes. In this study, we have investigated the relative strength of selection on pollen genes compared with sporophytic genes in A. thaliana. We present two major findings: 1) before becoming self-compatible, positive selection was stronger on pollen genes than sporophytic genes for A. thaliana and 2) current polymorphism data indicate that selection is weaker on pollen genes compared with sporophytic genes. This weaker selection on pollen genes can in part be explained by their higher tissue specificity, which in outbreeding plants can be outweighed by the effects of haploid expression and pollen competition. These results indicate that since A. thaliana has become self-compatible, selection on pollen genes has become more relaxed. This has led to higher polymorphism levels and a higher build-up of deleterious mutations in pollen genes compared with sporophytic genes.
Decreased ACKR3 (CXCR7) function causes oculomotor synkinesis in mice and humans
Authors: Whitman Mary C , Miyake Noriko , Nguyen Elaine H , Bell Jessica L , Matos Ruiz Paola M , Chan Wai-Man , Di Gioia Silvio Alessandro , Mukherjee Nisha , Barry Brenda J , Bosley T M , Khan Arif O , Engle Elizabeth C 
Published: June 2019

Abstract
Oculomotor synkinesis is the involuntary movement of the eyes or eyelids with a voluntary attempt at a different movement. The chemokine receptor CXCR4 and its ligand CXCL12 regulate oculomotor nerve development; mice with loss of either molecule have oculomotor synkinesis. In a consanguineous family with congenital ptosis and elevation of the ptotic eyelid with ipsilateral abduction, we identified a co-segregating homozygous missense variant (c.772G>A) in ACKR3, which encodes an atypical chemokine receptor that binds CXCL12 and functions as a scavenger receptor, regulating levels of CXCL12 available for CXCR4 signaling. The mutant protein (p.V258M) is expressed and traffics to the cell surface but has a lower binding affinity for CXCL12. Mice with loss of Ackr3 have variable phenotypes that include misrouting of the oculomotor and abducens nerves. All embryos show oculomotor nerve misrouting, ranging from complete misprojection in the midbrain, to aberrant peripheral branching, to a thin nerve, which aberrantly innervates the lateral rectus (as seen in Duane syndrome). The abducens nerve phenotype ranges from complete absence, to aberrant projections within the orbit, to a normal trajectory. Loss of ACKR3 in the midbrain leads to downregulation of CXCR4 protein, consistent with reports that excess CXCL12 causes ligand-induced degradation of CXCR4. Correspondingly, excess CXCL12 applied to ex vivo oculomotor slices causes axon misrouting, similar to inhibition of CXCR4. Thus, ACKR3, through its regulation of CXCL12 levels, is an important regulator of axon guidance in the oculomotor system; complete loss causes oculomotor synkinesis in mice, while reduced function causes oculomotor synkinesis in humans.