bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pengaruh Debt To Assets Ratio dan Return On Assets Terhadap Harga Saham
Authors: Ayu Lestari Devanka Regina , Lestiningsih Amin Setio , Dewi Intan Kusuma 
Published: November 2024

Pademi Covid-19 telah memberikan dampak signifikan terhadap berbagai sektor, termasuk perekonomian dan khususnya sektor transportasi dan logistik di Indonesia. Dampak ini tercermin dalam penurunan pertumbuhan ekonomi negara dan penurunan pendapatan serta laba perusahaan transportasi dan logistik pada tahun 2020. Tujuan penelitian ini yaitu untuk mengetahui pengaruh dari Debt to Assets Ratio (DAR) dan Return On Assets (ROA) terhadap harga saham. Penelitian ini menggunakan metode kuantitatif dan menggunakan jenis data sekunder yang diperoleh dari website resmi IDX dan Britama. Pemilihan sampel menggunakan teknik purposive sampling, diperoleh 11 perusahaan dengan total data sebanyak 33 yang sesuai dengan kriteria. Hasil analisis pada penelitian ini menunjukkan bahwa secara parsial DAR berpengaruh terhadap harga saham, dan ROA tidak berpengaruh terhadap harga saham. Sedangkan secara simultan DAR dan ROA terdapat pengaruh yang signifikan terhadap harga saham. Kesimpulannya bahwa secara bersama-sama (simultan) Debt to Assets Ratio (DAR) dan Return On Assets (ROA) berpengaruh signifikan terhadap harga saham pada sektor transportasi dan logistik yang terdaftar di Bursa Efek Indonesia periode 2020-2022.
El papel del disclosure en los posts de los influencers en Instagram
Authors: Trelles Villanueva Alicia , Martín-Cárdaba Miguel Angel 
Published: November 2024

Introducción: Ante el creciente auge del marketing de influencers, cada vez son más las investigaciones que están prestando atención a los diferentes aspectos éticos y comunicativos de esta nueva forma de publicidad. En concreto, muchos estudios han comenzado a examinar el impacto del disclosure en los posts esponsorizados. Así, esta investigación tiene como objetivo realizar una revisión teórica comprehensiva acerca del impacto comunicativo que el disclosure tiene sobre los receptores de estos mensajes publicitarios. Metodología: Para ello, en la presente investigación se ha realizado una revisión bibliográfica de la literatura publicada hasta el momento sobre el disclosure y sus efectos. Resultados: Este concepto ayuda a proteger a la audiencia y a detectar la naturaleza comercial de estas comunicaciones pero suele tener un impacto negativo en su eficacia publicitaria. Discusión: Es necesario tener en cuenta qué otras variables influyen y moderan el impacto del disclosure en la percepción de los seguidores. Conclusiones: El revelar la relación comercial es un recurso necesario para proteger a las audiencias ante este tipo de publicidad. Se requiere avanzar en la investigación para poder entender la manera más eficaz de realizarlo para que beneficie a consumidores, influencers y marcas.
Factors influencing the income of people with cerebral palsy in India and the tax rate
Authors: Shiva Chetan 
Published: November 2024

This study will examine the determinants of income among individuals with Cerebral Palsy (CP) in India, as well as the implications for income tax. People with cerebral palsy may have limitations in their economic and social opportunities, which can be impacted by factors such as age, gender, type of cerebral palsy, education level, social status, and family wealth. The researcher suggests that the current income tax system is reducing the earnings of persons with cerebral palsy (CP) and proposes changes to the income tax system in the postmodern period. In essence, persons with CP experience limited income sources, and the increased income tax rate is worsening many problems. Hence, it is crucial to enact enhancements in the current income tax structure. The study will employ case studies of persons with cerebral palsy to advocate for tax rate modifications in the postmodern period. The study employs postmodernism and the philosophy of science as the theoretical frameworks for the investigation. The aforementioned frameworks will be utilized to examine and dismantle the notions of socioeconomic class, educational background, and kind of child protection, while recognizing the subjective nature of these elements.
The Dynamics of Gender Equality Minangkabau Cultural Perspective and Its Implications for Counseling
Authors: Silvianetri Silvianetri , Irman Irman 
Published: November 2024

Gender equality is a problem that often occurs globally, nationally and locally. This study aims to reveal data related to the dynamics of gender equality from the perspective of Minangkabau culture and its implications for counseling. The research uses a qualitative approach with respondents from all walks of life, especially ninik mamak, cadiak pandai, religious scholars, bundo kanduang and counselor. The data collection techniques in this study are interviews and observation. The research steps are: 1) data collecting, 2) data reduction, 3) data display, and 4) conlusion. To maintain the validity of the data, data triangulation was carried out, especially triangulation of respondents. The results of the research reveal that according to customary law women have gender equality with men in the Minang Realm, but in reality there is still a lot of violence against women. The violence is; sexual violence, physical violence, sychological violence and economic violence. The problem of gender equality is handled by competent experts. One of them is a counselor. The counseling formats used are individual, group and classical formats The results of this study are expected to be initial data for future researchers who have an interest in researching gender equality.
Deepfake Detection Using Machine Learning Techniques: A Scalable Solution for Media Integrity
Authors: Pratik Godase  , Sanket Pawar  , Rohan Dhengale  , Shavarsiddha Gurav  , Avinash Kapare  
Published: November 2024

The proliferation of deepfake technology has introduced unprecedented challenges to media integrity and public trust. Leveraging advanced machine learning techniques, this study proposes a scalable solution for detecting deepfake content in digital media. Our methodology employs convolutional neural networks (CNNs) to capture spatial inconsistencies and recurrent neural networks (RNNs) to analyze temporal patterns in video data, ensuring comprehensive detection capabilities. Utilizing publicly available deepfake datasets, the proposed framework demonstrates high accuracy and robustness against various forgery methods. The results highlight the model's potential to address real-world challenges, offering a reliable approach to identifying manipulated content across diverse platforms. This research not only contributes to the growing field of deepfake detection but also underscores the critical role of scalable and adaptable solutions in combating the misuse of AI-generated media. Future work will focus on enhancing model generalization across emerging deepfake generation techniques.
How I Work Smarter: A Qualitative Analysis of Emergency Physicians' Strategies for Clinical and Non-clinical Productivity
Authors: Azan Benjamin , Innes Marilyn E , Thoma Brent , Lin Michelle , Duyvendyk Alex Van , Poonja Zafrina , Chan Teresa M. 
Published: November 2024

<p><strong>Introduction </strong>Emergency physicians' (EP) clinical and professional non-clinical environments can be stressful and lead to burnout. However, some EPs thrive in these environments. To date, there is limited research investigating the strategies that successful EPs use to be maximally productive. </p>
<p><strong>Methods </strong>A snowball sampling technique was used to identify peer-nominated EPs who were, within their community of practice, subjectively felt to be successful and efficient. Participants answered a standardized set of questions addressing their efficiency patterns that were published as part of the "How I Work Smarter" blog series on the Academic Life in Emergency Medicine website. Two reviewers performed an inductive qualitative thematic analysis to code and summarize their responses and develop a thematic framework that described patterns of EP productivity. </p>
<p><strong>Results</strong> Two themes, communication and efficiency, were applicable in the clinical and non-clinical arenas. Location and environment was a major theme in the non-clinical arena. The themes task management and prioritization, tools for wellness, and motivators spanned both environments. Each theme included several strategies that were felt by the respondents to improve productivity and efficiency. </p>
<p><strong>Conclusion </strong>We described a thematic framework of productivity strategies for EPs that may increase productivity, improve work-life balance, and decrease burnout. EPs interested in increasing their efficiency both within and beyond the clinical area may consider adopting these strategies.</p>
Penerapan Sistem Pelayanan Pendaftaran Pasien Rawat Jalan di RSUD Waluyo Jati
Authors: Daroin Himmatul Faroha , Ikawati Fita Rusdian , Fitriyani Endang 
Published: November 2024

ABSTRACT The first service that is directly related to patients is the registration service. The quality of health services can be improved to achieve optimal health. The effectiveness of patient registration services is one of the main indicators of improving the quality of hospital services. Therefore, patient registration services in hospitals and the factors that influence them are of interest to researchers. Customers who receive fast service do not have to wait long, which indicates high quality service. Substandard service at the registration counter can contribute to low customer satisfaction.9 The outpatient registration process at each health facility varies within the service system based on the institution's internal policies. However, there are still several obstacles in the outpatient registration process at the hospital, and some patients still do not fully understand the procedure. This study aims to provide a comprehensive overview of the outpatient registration services at Waluyo Jati Kraksaan Regional Hospital. At RSUD Waluyo Jati Kraksaan, a qualitative research approach was used through a series of direct observations and interviews. This research reveals that the outpatient registration system at RSUD Waluyo Jati Kraksaan operates both directly and indirectly. Several problems arose during the service process, including patients forgetting to bring identification. Keywords: Registration, Service, Outpatient ABSTRAK Layanan pertama yang berhubungan langsung dengan pasien adalah layanan registrasi. Mutu pelayanan kesehatan dapat ditingkatkan untuk mencapai derajat kesehatan yang optimal. Efektivitas pelayanan registrasi pasien merupakan salah satu indikator utama peningkatan mutu pelayanan rumah sakit. Oleh karena itu pelayanan pendaftaran pasien di rumah sakit serta faktor-faktor yang mempengaruhinya menjadi menarik bagi peneliti. Pelanggan yang mendapat pelayanan cepat tidak perlu menunggu lama, yang menandakan pelayanan berkualitas tinggi. Pelayanan yang kurang lancar di loket pendaftaran dapat berkontribusi terhadap rendahnya kepuasan pelanggan.9 Proses pendaftaran rawat jalan di setiap fasilitas kesehatan berbeda-beda dalam sistem pelayanan berdasarkan kebijakan internal institusi. Namun, masih terdapat beberapa kendala dalam proses pendaftaran rawat jalan di rumah sakit, dan sebagian pasien masih belum memahami sepenuhnya prosedurnya. Penelitian ini bertujuan untuk memberikan gambaran menyeluruh mengenai pelayanan pendaftaran rawat jalan RSUD Waluyo Jati Kraksaan. Di RSUD Waluyo Jati Kraksaan, pendekatan penelitian kualitatif digunakan melalui serangkaian observasi langsung dan wawancara. Penelitian ini mengungkapkan bahwa sistem registrasi rawat jalan RSUD Waluyo Jati Kraksaan beroperasi baik secara langsung maupun tidak langsung. Beberapa permasalahan muncul selama proses pelayanan, antara lain pasien lupa membawa identitas. Kata Kunci: Pendaftaran, Pelayanan, Rawat Jalan
Assessment of the bioactivity of bioinspired magnesium oxide nanoparticles from the Azadirachta indica extract
Authors: Al-Harbi Laila M. , Ezzeldien Mohammed , Elhenawy Ahmed A. , Said Alaa Hassan 
Published: November 2024

Azadirachta indica (neem) extract was used to biologically synthesize magnesium oxide nanoparticles (MgO NPs). The synthesized NPs were characterized using X-ray diffraction (XRD), thermogravimetric analysis (TGA), transmission electron microscopy (TEM), scanning electron microscopy (SEM), Fourier-transform infrared (FTIR), and UV-vis spectroscopy. Antioxidant, anticancer, antibacterial, antidiabetic, and anti-inflammatory activities were analyzed for the synthesized MgO NPs and neem extract. The obtained results confirmed the synthesis of spherical magnesium oxide nanoparticles with an average particle size of 23 nm using XRD. The samples exhibited good thermal stability and high stability in biological media. Compared to the neem extract and chemically synthesized magnesium oxide nanoparticles, the bioinspired magnesium oxide nanoparticles showed considerable free radical scavenging activity, with an IC50 value of 69.03 μg/mL. In addition, they reflected high selectivity to liver hepatic cancer cells with an IC50 value of 94.85 μg/mL without inducing any damage to human umbilical vein endothelial cells. The antibacterial activity of the bioinspired magnesium oxide nanoparticles demonstrated comparable effectiveness in treating both Gram-positive and Gram-negative bacterial strains. Furthermore, the produced bioinspired magnesium oxide nanoparticles showed a high percentage of inhibition for both α-amylase and α-glucosidase enzymes with an IC50 value of 61. 53 and 50.6 μg/mL, respectively. In addition, the bioinspired magnesium oxide nanoparticles also showed a higher denaturation inhibition percentage with an IC50 value of 6.66 μg/mL, indicating strong anti-inflammatory action. These enhanced abilities usher in a new bioinspired magnesium oxide nanoparticle bio-application era. Consequently, further in vivo studies are needed to assess the kinetic properties of these nanoparticles.
Impact of confirmatory test results on subtype classification and biochemical outcome following unilateral adrenalectomy in patients with primary aldosteronism
Authors: Daneshpour Hediyeh , Brüdgam Denise , Stüfchen Isabel , Heinrich Daniel Alexander , Bidlingmaier Martin , Beuschlein Felix , Kürzinger Lydia , Williams Tracy Ann , Reincke Martin , Schneider Holger , Adolf Christian 
Published: November 2024

ContextPrimary aldosteronism (PA) is the most common form of endocrine hypertension. According to the Endocrine Society Practice Guidelines, the diagnosis of PA requires a pathological screening test result and non-suppressible aldosterone levels during confirmatory testing. Sequential testing with more than one confirmatory test may result in discordant test results.Objective and patientsWe investigated the association of discordant results of captopril challenge test (CCT) and saline infusion test (SIT) on patient subtype classification by adrenal vein sampling (AVS) and outcome in 111 consecutive patients from the German Conn’s Registry. Concordance was defined as non-suppressible aldosterone levels upon both tests, while discordance was defined as conflicting test results. Patients with unilateral disease were offered adrenalectomy (ADX). Biochemical and clinical outcomes were assessed using the PASO criteria.Results85 of 111 (77%) patients had concordant results of CCT and SIT. Although baseline characteristics were comparable between patients with concordant and discordant tests, the latter had significantly lower aldosterone levels after testing (CCT: 170 vs. 114pg/ml; SIT: 139 vs. 101pg/ml; p=0.004). In 35% of patients with discordant (n=9) and 46% of concordant test results (n=39), AVS suggested lateralized PA. In 36 of 48 cases ADX was performed. 86% of patients with discordant and 72% with concordant results had complete biochemical success.ConclusionThe use of two confirmatory tests in patients with PA results in discordant results in approximately 23% of cases. Patients having discordant confirmatory test results had a comparable rate of lateralized PA and underwent adrenalectomy with similar long-term outcome.
Whole mitochondrial genome analyses of Han population from Shandong of China using massively parallel sequencing
Authors: Zhang Jiashuo , Li XueBo , Chen Anqi , Ding Mingxia , Li Liangliang , Qi Yinghua , Ding Chunli , Cai Dawei , Zhang Suhua 
Published: November 2024

IntroductionMitochondrial DNA (mtDNA) has been extensively utilized in archeology, human evolutionary genetics, and forensic genetic for over three decades, primarily due to its maternal inheritance and relatively high mutation rate. The Chinese Han, the largest and most widely distributed ethnic group in China, have been the focus of numerous genetic studies. However, the forensic parameters and genetic structure of the Shandong Han, specifically in relation to the whole mitochondrial genome, remain undocumented.MethodsWe performed whole mitochondrial genome sequencing on 141 unrelated Han individuals from Shandong province using massively parallel sequencing.ResultsA total of 135 unique mtDNA haplotypes were identified, classified into 105 haplogroups, resulting in a haplotype diversity value of 0.9993. The discriminatory capacity of whole mitochondrial genome was calculated at 0.9574, compared to 0.8936 when only the control region was analyzed. The majority of the haplogroups observed were specific to East Asian lineages, including D4, D5 and F1. Population comparisons revealed that the modern Shandong Han share genetic connections with ancient populations from the Yellow River and West Liao River basins. Additionally, the Shandong Han may have integrated a significant number of maternal lineages from other regions during their development. The demographic expansion of the Shandong Han is estimated to have occurred approximately 9,000 years ago, corresponding to the Neolithic period, a time of significant cultural and technological development.DiscussionThe dataset generated in this study is available in the EMPOP database under the accession number EMP00886 and will serve as an important mtDNA reference for forensic casework in China. The study of whole mitochondrial genome based on the analysis of matrilineal genetic structure of the Shandong Han population can help to enrich the forensic mtDNA reference database in East Asia and provide reference for future archeology and forensic genetics research.
The close association of Muribaculum and PA (10:0/a-17:0) with the occurrence of pancreatic ductal adenocarcinoma and immunotherapy
Authors: Wang Enzhao , Ren Kuiwu , Wang Xiangyu , Du Sen , Gao Xiang , Niu Wang , Guan Chenyue , Liu Xue , Wu Panpan , Liu Chunlong , Yu Jiangtao , Song Kun 
Published: November 2024

BackgroundProgress in immunotherapy for pancreatic ductal adenocarcinoma (PDAC) has been slow, yet the relationship between microorganisms and metabolites is crucial to PDAC development. This study compares the biliary microbiota and metabolomic profiles of PDAC patients with those of benign pancreatic disease patients to investigate PDAC pathogenesis and its relationship with immunotherapy.MethodsA total of 27 patients were recruited, including 15 diagnosed with PDAC and 12 with benign pancreaticobiliary conditions, all of whom underwent surgical treatment. Intraoperative bile samples were collected and analyzed using 16S rRNA sequencing in conjunction with liquid chromatography-mass spectrometry (LC-MS). Multivariate statistical methods and correlation analyzes were employed to assess differences in microbial composition, structure, and function between malignant and benign pancreatic diseases. Additionally, a retrospective analysis was conducted on PDAC patients post-surgery regarding immunotherapy and its correlation with metabolic components.ResultsPDAC patients exhibited a significantly higher abundance of bile microbiota compared to controls, with notable differences in microbiota structure between the two groups (P &lt; 0.05). At the genus level, Muribaculum was markedly enriched in the bile of PDAC patients and was strongly correlated with phosphatidic acid (PA) (10:0/a-17:0). Both of these components, along with the tumor marker CA199, formulated a predictor of PDAC. Furthermore, PA (10:0/a-17:0) demonstrated a strong correlation with PDAC immunotherapy outcomes (Rho: 0.758; P=0.011).ConclusionThese findings suggest that the biliary microbiota and associated metabolites play a crucial role in the development of PDAC and may serve as potential predictive biomarkers and therapeutic targets for disease management.
Comparative skin transcriptome analysis as a potential tool to investigate intra- and inter-population differences in belugas
Authors: Unal Ebru , Singh Vijender , Suydam Robert , Goertz Caroline E. C. , Romano Tracy A. 
Published: November 2024

IntroductionAs long-lived top predators inhabiting the Arctic and subarctic, belugas are under threat of anthropogenic stressors including climate change, pollution, noise, and habitat degradation, which in turn can negatively affect their health and viability. There is currently a need for health indicators that can be easily collected and used to assess and monitor the response to stressors in whales. Comparative transcriptomics using skin tissue can be used to provide understanding of organismal responses to stressors at the cellular level.MethodsFor this study, intra- and inter-population comparisons were performed using the skin transcriptomes obtained from Bristol Bay (BB) belugas sampled in spring and late summer, and Eastern Chukchi Sea (ECS) belugas sampled in early summer in Alaska to investigate significantly differentially expressed genes over 2-fold change (padj&lt;0.05).ResultsBoth principal component and hierarchical clustering analysis showed separate clustering of ECS whales, with further clustering of BB whales based on season. Intra-population comparisons carried out between different sexes and age groups did not result in any significant changes. However, the samples collected in spring versus summer within BB stock resulted in 541 significantly regulated genes, with significant activation (z-score≥|2|) predictions in pathways related with extracellular matrix organization, collagen biosynthesis and degradation, wound healing and cytokine signaling, potentially suggesting epidermal changes occurring in preparation for the seasonal molt in BB whales. The inter-population comparisons performed separately for BB-Spring versus ECS and BB-Summer versus ECS resulted in 574 and 938 significantly regulated genes, respectively. The significantly enriched canonical pathways common to both comparisons suggest increased cell survival and host defense responses along with increased cellular maintenance and growth in BB whales, and increased inflammation in ECS whales.DiscussionThese changes observed could potentially be due to differences in molting, bias in hunting preferences and/or differences in environmental conditions during the time of sampling. Findings from this study suggest comparative skin transcriptomics as a useful tool towards understanding biologically relevant gene expression differences at different temporal and spatial scales among beluga stocks with potential to inform and contribute to conservation and recovery of endangered beluga stocks.