bluuebunny/crossref_metadata_2025_split huggingface dataset:
Acute fibrinous and organizing pneumonia associated to hematological malignancy: a case report
Authors: Pereira Filipa Ferreira , Santos Mario , Silva Margarida Freitas 
Published: May 2018

Background:
The acute fibrinoid and organizing pneumonia (AFOP) is an histopathological patern, characterized by the presence of intra-alveolar fibrin and organizing pneumonia. AFOP is an entity that can be either idiopathic or associated with several clinical conditions including infectious diseases, drug interactions, and cancer. No specific treatment exists for AFOP but an excellent response to the steroid therapy has been observed.

Case Presentation:
A 55-year-old man was admited to the hospital with pneumonia diagnosis. He did not respond to antibiotics, but an excellent response to steroids was observed. Lung biopsy was done that supported the diagnosis of AFOP. After discharge, bone marrow aspiration was repeated and the diagnosis of acute myeloid leukemia with myelodysplasia-related changes was confirmed. The patient started chemotherapy but after several infections and cerebrovascular complications, the patient passed away.

Conclusion:
AFOP is a rare entity associated with several diseases and often misdiagnosed as an infectious process. The diagnosis is based on histopathology and the treatment is based on steroids. Many questions still remain unanswered regarding this disease.
Revision of the crystal structure of “‘bis glycine’ squarate” [Tyagi et al., RSC Adv., 2016, 6, 24565]
Authors: Seidel Rüdiger W. 
Published: May 2018

The crystal structure of “‘bis glycine’ squarate”, recently published in RSC Advances [Tyagi et al., RSC Adv. 2016, 6, 24565], is revised. Re-refinement of the structure againstthe original X-ray diffraction data after correct placement of the donor hydrogen atoms proves that the compound is the previously reported diglycinium squarate [Aniola et al.,New J. Chem. 2014, 38, 3556].
Identification of Mi-1 homologs in various Solanum species
Authors: Carrera Pacheco Saskya Estefany , Chacón Acosta María Gabriela , Vallejo López María José , Jarrín Cornejo Francisco Javier , Oliva Pérez Ricardo Francisco , Proaño Karina Isabel 
Published: May 2018

In Ecuador, several solanaceous crops, including naranjilla (Solanum quitoense), are attacked by the nematode Meloidogyne sp. Resistant cultivars are not available and there is a need to identify potential sources of resistance that can be incorporated into breeding programs. The Mi-1 gene from S. peruvianum is known to confer resistance to Meloidogyne in tomato (S. lycopersicum).
In this study, 42 plant accessions of wild and cultivated Solanum species were screened to identify the presence of this gene, its diversification, expression, and evidence of gene recombination. The Mi-1 gene (exon 3) was identified in 34 accessions. Sixteen alleles were identified, that encode 15 different amino acid sequences, all of which encode NBS-LRR proteins and share 72-96 % homology with the tomato Mi-1 protein. The Mi-1 locus was highly polymorphic; most polymorphisms tend to accumulate in the NBS rather than in the LRR region. Genetic recombination was detected among the tomato and potato relate d sequences, but it was absent in the naranjilla group. Homologs identified expressed in both non-infected roots and leaves of some accessions, suggesting the constitutive expression of the gene.
Pengaruh Model Learning Cycle 5E Berbasis Eksperimen Terhadap Kemampuan Berpikir Kritis Fisika Peserta Didik Kelas XI SMAN 1 Gerung
Authors: Septiana I'in Senja , Harjono Ahmad , Hikmawati Hikmawati 
Published: May 2018

This research aims to determine the effect of experimental based learning cycle 5E model to the critical thinking ability of physics students class XI SMAN 1 Gerung. This research is a quasi experimental research with design called "untreated control group design with pretest and posttes". The population in this study is all students of class XI SMA Negeri 1 Gerung, and sampling technique using purposive sampling. There are two samples taken are class XI MIPA-3 as experiment class and XI MIPA-2 as control class. The data collection critical thinking ability using the technique to description of 6 questions. Based on the result, it is found that the average posttest of experimental critical thinking ability is 70,28 and control class is 62,39. The obtained data were first tested for normality and homogeneity. Both classes were normally distributed and homogeneous, followed by hypothesis testing using statistical test (t-test polled variance). The hypothetical test of critical thinking ability was obtained by ÃÂ of 3.38, of 1.99 at significant level of 0.05, because ÃÂ is greater than ÃÂ , H0 is rejected and Ha is accepted. The conclusion of this research, there is influence of experimental based learning cycle 5E model to the critical thinking ability of physics learners class XI SMAN 1 Gerung.
Which Risk Factors Causally Influence Dementia? A Systematic Review of Mendelian Randomization Studies
Authors: Kuźma Elżbieta , Hannon Eilis , Zhou Ang , Lourida Ilianna , Bethel Alison , Levine Deborah A. , Lunnon Katie , Thompson-Coon Jo , Hyppönen Elina , Llewellyn David J. 
Published: May 2018

Background: Numerous risk factors for dementia are well established, though the causal nature of these associations remains unclear. Objective: To systematically review Mendelian randomization (MR) studies investigating causal relationships between risk factors and global cognitive function or dementia. Methods: We searched five databases from inception to February 2017 and conducted citation searches including MR studies investigating the association between any risk factor and global cognitive function, all-cause dementia or dementia subtypes. Two reviewers independently assessed titles and abstracts, full-texts, and study quality. Results: We included 18 MR studies investigating education, lifestyle factors, cardiovascular factors and related biomarkers, diabetes related and other endocrine factors, and telomere length. Studies were of predominantly good quality, however eight received low ratings for sample size and statistical power. The most convincing causal evidence was found for an association of shorter telomeres with increased risk of Alzheimer’s disease (AD). Causal evidence was weaker for smoking quantity, vitamin D, homocysteine, systolic blood pressure, fasting glucose, insulin sensitivity, and high-density lipoprotein cholesterol. Well-replicated associations were not present for most exposures and we cannot fully discount survival and diagnostic bias, or the potential for pleiotropic effects. Conclusions: Genetic evidence supported a causal association between telomere length and AD, whereas limited evidence for other risk factors was largely inconclusive with tentative evidence for smoking quantity, vitamin D, homocysteine, and selected metabolic markers. The lack of stronger evidence for other risk factors may reflect insufficient statistical power. Larger well-designed MR studies would therefore help establish the causal status of these dementia risk factors.
Participation and the Role of Neuropsychological Functioning in Myotonic Dystrophy Type 1
Authors: Van Heugten Caroline , Meuleman Susan , Hellebrekers Danique , Kruitwagen-van Reenen Esther , Visser-Meily Johanna 
Published: May 2018

Background: Myotonic Dystrophy type 1 (DM1) is primarily a neuromuscular disease but can also have neuropsychological consequences (i.e.cognitive, emotional and behavioural) which can influence daily living and societal participation. Not much is known about the level of participation of DM1 patients and their relatives and the factors influencing participation. This information can guide the development of rehabilitation programs and identify those at risk of long-term participation problems. Objective: To investigate the level of participation of DM1 patients and their partners and the determinants. Methods: Cross-sectional study using the Utrecht Scale for Evaluation of Rehabilitation-Participation. Determinants were demographic, disease related, and neuropsychological characteristics. Spearman correlations and backward multiple regression analyses were performed. Results: Of the 66 DM1 participants, 54% reported severe fatigue and 47% apathy. Experienced participation restrictions were most prevalent in housekeeping (74%), sports (68%) and outdoor activities (55%). Participants were relatively satisfied with their level of participation, but dissatisfaction occurred mostly in housekeeping (58%), outdoor activities (55%), and sports (54%). Age and apathy were significant predictors of frequency of (R2 = 10.4) and restrictions in participation in the multivariate model (R2 = 14.4). Emotional functioning was the only significant predictor of satisfaction with participation (R2 = 23.8). Conclusions: A considerable number of DM1 patients have Central Nervous System-related problems such as fatigue and apathy in addition to neuromuscular restrictions. Risk factors for lower participation are age, apathy, and emotional problems. Physical as well as neuropsychological rehabilitation programs are recommended.
Evaluator Training and Reliability for SMA Global Nusinersen Trials
Authors: Glanzman Allan M. , Mazzone Elena S. , Young Sally Dunaway , Gee Richard , Rose Kristy , Mayhew Anna , Nelson Leslie , Yun Chris , Alexander Katie , Darras Basil T. , Zolkipli-Cunningham Zarazuela , Tennekoon Gihan , Day John W. , Finkel Richard S. , Mercuri Eugenio , De Vivo Darryl C. , Baldwin Ron , Bishop Kathie M. , Montes Jacqueline 
Published: May 2018

Background: Training methodology was established to optimize reliability of outcome measures in the nusinersen clinical trials. The Children’s Hospital of Philadelphia Infant Test of Neuromuscular Disorders (CHOP INTEND), Hammersmith Functional Motor Scale Expanded (HFMSE), and Revised Upper Limb (RULM) were primary or secondary outcomes. Methods: Video review, quarterly conference calls, and item scoring checks supported evaluator competence. Baseline and screening along with video review established intra and inter-rater reliability. Results: Inter and intra-rater reliability were both excellent. Intraclass correlation coefficients (ICC) ranged between 0.906–0.994 across initial training meetings and 0.824–0.996 across annual retraining meetings. This was similar for CHOP INTEND (ICC = 0.824–0.951), HFMSE (ICC = 0.981–0.996), and RULM (ICC = 0.966–0.990). Intra-rater reliability for the CHOP INTEND, HFMSE, and RULM were ICC = 0.895 (95% CI: 0.852–0.926; n = 116), ICC = 0.959 (95% CI: 0.942–0.971; n = 125), and ICC = 0.948 (95% CI: 0.927–0.963; n = 126) respectively. Conclusions: Rigorous evaluator training ensures reliability of assessment of subjects with spinal muscular atrophy (SMA) in multicenter international trials.
A similarity measure method combining location feature for mammogram retrieval
Authors: Wang Zhiqiong , Xin Junchang , Huang Yukun , Li Chen , Xu Ling , Li Yang , Zhang Hao , Gu Huizi , Qian Wei 
Published: May 2018

BACKGROUND: Breast cancer, the most common malignancy among women, has a high mortality rate in clinical practice. Early detection, diagnosis and treatment can reduce the mortalities of breast cancer greatly. The method of mammogram retrieval can help doctors to find the early breast lesions effectively and determine a reasonable feature set for image similarity measure. This will improve the accuracy effectively for mammogram retrieval. METHODS: This paper proposes a similarity measure method combining location feature for mammogram retrieval. Firstly, the images are pre-processed, the regions of interest are detected and the lesions are segmented in order to get the center point and radius of the lesions. Then, the method, namely Coherent Point Drift, is used for image registration with the pre-defined standard image. The center point and radius of the lesions after registration are obtained and the standard location feature of the image is constructed. This standard location feature can help figure out the location similarity between the image pair from the query image to each dataset image in the database. Next, the content feature of the image is extracted, including the Histogram of Oriented Gradients, the Edge Direction Histogram, the Local Binary Pattern and the Gray Level Histogram, and the image pair content similarity can be calculated using the Earth Mover’s Distance. Finally, the location similarity and content similarity are fused to form the image fusion similarity, and the specified number of the most similar images can be returned according to it. RESULTS: In the experiment, 440 mammograms, which are from Chinese women in Northeast China, are used as the database. When fusing 40% lesion location feature similarity and 60% content feature similarity, the results have obvious advantages. At this time, precision is 0.83, recall is 0.76, comprehensive indicator is 0.79, satisfaction is 96.0%, mean is 4.2 and variance is 17.7. CONCLUSIONS: The results show that the precision and recall of this method have obvious advantage, compared with the content-based image retrieval.
A 3 year old baby with wasp stings-induced multiorgan dysfunction
Authors: Ahmed Farzana , Raj Aftab Yusuf , Sayeed Ahmed , Hasan Zahidul , Kabir Muhammod Humayun 
Published: May 2018

This article has no abstract. The first 100 words appear below:A 3 year old healthy female baby had been stung with a swarm of wasps on her entire body while passing a coconut tree containing wasp nest at Chakoria, Cox’s Bazar. She developed severe pain and itching at the site of stings and swelling of the body within minutes. Immediately she was seen by a local physician and was treated with the injection of hydrocortisone and pheniramine maleate. On the following day, she gradually developed yellowish tint of the whole body (Figure 1), followed by passage of reddish scanty urine. For these reasons, she was referred to Chittagong Medical College and Hospital and was treated with injection cefotaxime, flucloxacillin, hydrocortisone and dopamine.
New Insights into the Formation of the Blue Main Sequence in NGC 1850
Authors: Yang Yujiao , Li Chengyuan , Deng Licai , Grijs Richard de , Milone Antonino P. 
Published: May 2018

Abstract
Recent discoveries of bimodal main sequences (MSs) associated with young clusters (with ages ≲1 Gyr) in the Magellanic Clouds have drawn a lot of attention. One of the prevailing formation scenarios attributes these split MSs to a bimodal distribution in stellar rotation rates, with most stars belonging to a rapidly rotating population. In this scenario, only a small fraction of stars populating a secondary blue sequence are slowly or non-rotating stars. Here, we focus on the blue MS in the young cluster NGC 1850. We compare the cumulative number fraction of the observed blue-MS stars to that of the high-mass-ratio binary systems at different radii. The cumulative distributions of both populations exhibit a clear anti-correlation, characterized by a highly significant Pearson coefficient of −0.97. Our observations are consistent with the possibility that blue-MS stars are low-mass-ratio binaries, and therefore their dynamical disruption is still ongoing. High-mass-ratio binaries, on the other hand, are more centrally concentrated.
A Search for H i Lyα Counterparts to Ultrafast X-Ray Outflows
Authors: Kriss Gerard A. , Lee Julia C. , Danehkar Ashkbiz 
Published: May 2018

Abstract
Prompted by the H i Lyα absorption associated with the X-ray ultrafast outflow at −17,300 km s−1 in the quasar PG 1211+143, we have searched archival UV spectra at the expected locations of H i Lyα absorption for a large sample of ultrafast outflows identified in XMM-Newton and Suzaku observations. Sixteen of the X-ray outflows have predicted H i Lyα wavelengths falling within the bandpass of spectra from either the Far Ultraviolet Spectroscopic Explorer or the Hubble Space Telescope, although none of the archival observations were simultaneous with the X-ray observations in which ultrafast X-ray outflows (UFOs) were detected. In our spectra broad features with FWHM of 1000 km s−1 have 2σ upper limits on the H i column density of generally ≲2 × 1013 cm−2. Using grids of photoionization models covering a broad range of spectral energy distributions (SEDs), we find that producing Fe xxvi Lyα X-ray absorption with equivalent widths >30 eV and associated H i Lyα absorption with

requires total absorbing column densities

and ionization parameters log ξ ≳ 3.7. Nevertheless, a wide range of SEDs would predict observable H i Lyα absorption if ionization parameters are only slightly below peak ionization fractions for Fe xxv and Fe xxvi. The lack of Lyα features in the archival UV spectra indicates that the UFOs have very high ionization parameters, that they have very hard UV-ionizing spectra, or that they were not present at the time of the UV spectral observations owing to variability.
Complex Lyα Profiles in Redshift 6.6 Ultraluminous Lyα Emitters*

†
Authors: Songaila A. , Hu E. M. , Barger A. J. , Cowie L. L. , Hasinger G. , Rosenwasser B. , Waters C. 
Published: May 2018

Abstract
We report on a search for ultraluminous Lyα-emitting galaxies (LAEs) at z = 6.6 using the NB921 filter on the Hyper Suprime-Cam on the Subaru telescope. We searched a 30 deg2 area around the north ecliptic pole, which we observed in broadband g′, r′, i′, z′, and y′ and narrowband NB816 and NB921, for sources with NB921 < 23.5 and z′-NB921 > 1.3. This corresponds to a selection of log L(Lyα) > 43.5 erg s−1. We followed up seven candidate LAEs (out of 13) with the Keck DEIMOS spectrograph and confirmed five z = 6.6 LAEs, one z = 6.6 AGN with a broad Lyα line and a strong red continuum, and one low-redshift ([O iii] 5007) galaxy. The five ultraluminous LAEs have wider line profiles than lower-luminosity LAEs, and one source, NEPLA4, has a complex line profile similar to that of COLA1. In combination with previous results, we show that the line profiles of the z = 6.6 ultraluminous LAEs are systematically different from those of lower-luminosity LAEs at this redshift. This result suggests that ultraluminous LAEs generate highly ionized regions of the intergalactic medium in their vicinity that allow the full Lyα profile of the galaxy—including any blue wings—to be visible. If this interpretation is correct, then ultraluminous LAEs offer a unique opportunity to determine the properties of the ionized zones around them, which will help in understanding the ionization of the z ∼ 7 intergalactic medium. A simple calculation gives a very rough estimate of 0.015 for the escape fraction of ionizing photons, but more sophisticated calculations are needed to fully characterize the uncertainties.
Combined Constraints on the Equation of State of Dense Neutron-rich Matter from Terrestrial Nuclear Experiments and Observations of Neutron Stars
Authors: Zhang Nai-Bo , Li Bao-An , Xu Jun 
Published: May 2018

Abstract
Within the parameter space of the equation of state (EOS) of dense neutron-rich matter limited by existing constraints mainly from terrestrial nuclear experiments, we investigate how the neutron star maximum mass M
max > 2.01 ± 0.04 M
⊙, radius 10.62 km < R
1.4 < 12.83 km and tidal deformability Λ1.4 ≤ 800 of canonical neutron stars together constrain the EOS of dense neutron-rich nucleonic matter. While the 3D parameter space of K
sym (curvature of nuclear symmetry energy), J
sym, and J
0 (skewness of the symmetry energy and EOS of symmetric nuclear matter, respectively) is narrowed down significantly by the observational constraints, more data are needed to pin down the individual values of K
sym, J
sym, and J
0. The J
0 largely controls the maximum mass of neutron stars. While the EOS with J
0 = 0 is sufficiently stiff to support neutron stars as massive as 2.37 M
⊙, supporting the hypothetical ones as massive as 2.74 M
⊙ (composite mass of GW170817) requires J
0 to be larger than its currently known maximum value of about 400 MeV and beyond the causality limit. The upper limit on the tidal deformability of Λ1.4 = 800 from the recent observation of GW170817 is found to provide upper limits on some EOS parameters consistent with but far less restrictive than the existing constraints of other observables studied.
Electron–Positron Pair Creation Close to a Black Hole Horizon: Redshifted Annihilation Line in the Emergent X-Ray Spectra of a Black Hole. I.
Authors: Laurent Philippe , Titarchuk Lev 
Published: May 2018

Abstract
We consider a Compton cloud (CC) surrounding a black hole (BH) in an accreting BH system, where electrons propagate with thermal and bulk velocities. In that cloud, soft (disk) photons may be upscattered off these energetic electrons and attain energies of several MeV. They could then create pairs due to photon–photon interactions. In this paper, we study the formation of the 511 keV annihilation line due to this photon–photon interaction, which results in the creation of electron–positron pairs, followed by the annihilation of the created positrons with the CC electrons. The appropriate conditions for annihilation-line generation take place very close to a BH horizon within (103–104)m cm from it, where m is the BH hole mass in solar units. As a result, the created annihilation line should be seen by the Earth observer as a blackbody bump, or the so-called reflection bump at energies around (511/20) (20/z) keV, where z ∼ 20 is a typical gravitational redshift experienced by the created annihilation-line photons when they emerge. This transient feature should occur in any accreting BH system, either galactic or extragalactic. Observational evidences for this feature in several galactic BH systems is detailed in an accompanying paper. An extended hard tail of the spectrum up to 1 MeV may also be formed due to X-ray photons upscattering off created pairs.
Increases to Inferred Rates of Planetesimal Accretion due to Thermohaline Mixing in Metal-accreting White Dwarfs
Authors: Bauer Evan B. , Bildsten Lars 
Published: May 2018

Abstract
Many isolated, old white dwarfs (WDs) show surprising evidence of metals in their photospheres. Given that the timescale for gravitational sedimentation is astronomically short, this is taken as evidence for ongoing accretion, likely of tidally disrupted planetesimals. The rate of such accretion,

, is important to constrain, and most modeling of this process relies on assuming an equilibrium between diffusive sedimentation and metal accretion supplied to the WD’s surface convective envelope. Building on the earlier work of Deal and collaborators, we show that high

models with only diffusive sedimentation are unstable to thermohaline mixing and that models that account for the enhanced mixing from the active thermohaline instability require larger accretion rates, sometimes reaching

to explain observed calcium abundances. We present results from a grid of MESA models that include both diffusion and thermohaline mixing. These results demonstrate that both mechanisms are essential for understanding metal pollution across the range of polluted WDs with hydrogen atmospheres. Another consequence of active thermohaline mixing is that the observed metal abundance ratios are identical to accreted material.