bluuebunny/crossref_metadata_2025_split huggingface dataset:
Orthotics and Prosthesis Management in Nicolaides-Baraitser Syndrome
Authors: Alsancak Serap , Güven Enver , Güner Senem , Özgün Ali Koray , Vasefnia Alireza 
Published: February 2025

ABSTRACT

Introduction
The research aimed to increase the quality of life in this rare disease by including orthotic and prosthetic treatment approaches, which are not found in the literature, in the treatment protocol of a child with Nicolaides-Baraitser syndrome (NCBRS) diagnosis who has multiple congenital anomalies. In addition to the anomalies seen in different parts of the body of the patient with NCBR, there are deformities and anomalies in the limbs. It was planned to design and produce the most suitable prosthesis and orthosis for the child by making clinical prosthetic and orthotic evaluations.

Method
Orthoses were produced using two different methods: traditional fabrication and 3D printing. Functional and satisfaction outcomes were measured.

Results
The Pediatric Balance Scale scores were 36 with the polypropylene knee-ankle-foot orthosis (PP-KAFO) and 30 with the 3D-printed knee-ankle-foot orthosis (3D-KAFO). The timed up and go (TUG) scores were 24.7 seconds with the PP-KAFO and 23.5 seconds with the 3D-KAFO. Pediatric Reach Test results showed similar forward reach for both devices, with slight differences in lateral reach directions. Stride length and stride time increased, while cadence and walking speed decreased with the PP-KAFO compared with the 3D-KAFO. According to the Quebec User Evaluation of Satisfaction with Assistive Technology (QUEST) survey, satisfaction levels ranged from “more or less satisfied” to “very satisfied,” with total satisfaction being equal for both KAFO conditions.

Conclusions
There is no difference between the 3D-printed orthosis and PP-KAFO in patient satisfaction with NCBRS in the functional tests.

Clinical Relevance
Orthoses produced with 3D printers can be used instead of orthoses produced using traditional methods. However, larger sample groups are needed.
Breastfeeding after gestational diabetes mellitus: maternal, milk and infant outcomes
Authors: Geddes Donna T. , Gridneva Zoya , Perrella Sharon L. 
Published: February 2025

Purpose of review
This review examines the complex relationship between gestational diabetes mellitus (GDM) and breastfeeding outcomes, integrating recent evidence on maternal health benefits, milk composition, and clinical support strategies. Understanding these relationships is important as GDM affects approximately 14% of pregnancies worldwide, with rates continuing to rise alongside increasing obesity and maternal age.

Recent findings
Women who breastfeed for longer periods after GDM show significant improvements in metabolic health, including reduced weight retention and better cardiometabolic profiles. While macronutrient content of breast milk appears preserved, significant differences exist in human milk oligosaccharides and milk fat globule membrane proteins. A previous history of predominant breastfeeding shows a 47% reduction in abnormal fasting glucose odds in subsequent pregnancies. Initial positive indications of personalized support programs, particularly during pregnancy, are emerging however evaluation in comparison to current evidence-based interventions is yet to be carried out. Lifestyle factors are known to reduce subsequent diabetes after a GDM and recent evidence suggests these are important in pregnancy and may improve breastfeeding outcomes.

Summary
Despite the challenges of delayed secretory activation and reduced milk supply in women with GDM, successful breastfeeding offers substantial health benefits. Healthcare providers could implement comprehensive, individualized support strategies beginning in pregnancy and extending through the postpartum period to optimize outcomes for both mother and infant.
Endoscopic submucosal dissection combined surgery for the treatment of ectopic gastric mucosa and ectopic pancreas in muscularis propria and serosal layer of the stomach: A rare case report and review of the literature
Authors: Chen Yindi , Cao Yanbing , Zhi Lingran , Huang Rui 
Published: February 2025

Rationale:
Ectopic gastric mucosa (EGM) and ectopic pancreas (EP) in the stomach is a rare congenital anomaly. No research on the coexistence of EGM and EP in the stomach has been found. However, several studies have shown canceration of EGM outside the stomach and EP. Active surgical treatment may be necessary. This paper introduces a new case of ectopic gastric mucosa and ectopic pancreas in muscularis propria and serosal layer of the stomach and which were ultimately removed by endoscopic submucosal dissection combined surgery.

Patient concerns:
The patient was a 25-year-old male. Upper gastrointestinal endoscopy showed a subepithelial lesion in gastric antrum.

Diagnoses:
Postoperative pathology confirmed a diagnosis of EGM and EP.

Interventions:
Enhanced computed tomography scan and endoscopic ultrasonography showed a submucosal tumor. Then endoscopic submucosal dissection was performed, during which a lesion was observed on the anterior wall of the stomach near the pylorus. This lesion invades the muscularis propria of the stomach and the large lesions near the pylorus may lead to pyloric obstruction. Considering these situations comprehensively, the patient ultimately underwent surgical resection of gastric lesion and partial gastrectomy.

Outcomes:
After 3 months of follow-up, the patient was recovering well and no recurrence of the lesion was found so far.

Lessons:
EGM along with EP in the stomach is a rare condition. Due to its rarity, there was a lack of sufficient data support for its treatment and prognosis. Due to the EGM and EP may become cancerous, clinical attention should be paid to it. In this study, we present a new case report of EGM along with EP in the stomach and review the existing literature to explore treatment options for it.
The efficacy of Shenyankangfu tablets in combination with valsartan in diabetic nephropathy: A systematic review and meta-analysis
Authors: Yang Yang , Zhang Xinyu , Yuan Yin , Wang Mengyang , Xue Yuqing , Wang Hongwu , Zhao Tieniu 
Published: February 2025

Background:
Diabetic nephropathy (DN) is the most prevalent and critical microvascular complication of diabetes mellitus, constituting a significant contributor to end-stage renal disease. Shenyankangfu tablets (SYKFP) are a pure traditional Chinese medicine compound. Current studies have shown that SYKFP combined with valsartan in the treatment of DN had therapeutic advantages. However, there is still a lack of systematic research. Therefore, meta-analysis was used to systematically evaluate the efficacy and safety of SYKFP combined with valsartan in treating DN and to provide evidence-based medical evidence for clinical application.

Methods:
CNKI, VIP, Wanfang, Chinese Biomedical Literature Service System, American Clinical Trial Registry, Embase, Web of Science, PubMed, and Cochrane Library databases were searched from the date of database establishment to August 2024. All randomized controlled trials of SYKFP in combination with valsartan for treating DN were collected, and the data of clinical trials that met the inclusion criteria were extracted. Meta-analysis was performed using Review Manager 5.4 and Stata 17.0.

Results:
Sixty-nine pieces of literature were retrieved, and 14 eligible randomized controlled trials were selected, with 1281 participants. The results of the meta-analysis showed that compared with valsartan alone in the treatment of DN, Shenyanangfu tablets combined with valsartan can improve the clinical efficacy rate (relative risk = 1.16, 95% CI [1.11, 1.22], P < .00001) and reduce blood creatinine (mean difference [MD] = −28.79, 95% CI [−31.16, −26.42], P < .00001), urea nitrogen (MD = −1.37, 95% CI [−1.52, −1.22], P < .00001), 24-hour urine protein quantification (MD = −0.59, 95% CI [−0.77, −0.40], P < .00001), fasting blood glucose (MD = −0.51, 95% CI [−0.77, −0.25], P = .0001) and the incidence of adverse events (relative risk = 0.74, 95% CI [0.43, 1.23], P = .24) were better than valsartan alone, and the difference was statistically significant.

Conclusion:
SYKFP combined with valsartan can improve the clinical treatment efficiency of DN. They can effectively reduce the occurrence of urea nitrogen, blood creatinine, 24-hour urine protein quantification, fasting blood glucose, and adverse events.
HLA genotyping in cardiac and other extrapulmonary manifestations of sarcoidosis
Authors: Şenay Ece Ünüvar , Korkmaz Celalettin , Zamani Ayşegül , Zamani Adil , Demirbaş Soner , Yildirim Mahmut Selman 
Published: February 2025

Background:
Although numerous candidate genes have been identified in studies investigating the role of genetics in sarcoidosis, the strongest association has been reported with the Major Histocompatibility Complex/Human Leucocyte Antigen (MHC/HLA) region. This study aimed to evaluate HLA polymorphism and assess its association with cardiac and other extrapulmonary involvement in sarcoidosis patients.

Methods:
The study included 67 patients diagnosed with sarcoidosis. A control group of 100 bone marrow donors, who had undergone HLA genotyping previously, was also included. Blood samples were collected from all participants for HLA gene polymorphism analysis. The differences in HLA genotypes were investigated between patients with and without cardiac and other extrapulmonary involvement, and between these groups and the control group.

Results:
Cardiac involvement, was present in 17.9% of the patients. The most frequently affected extrapulmonary organ was the skin (23.8%). HLA DQB103 and HLA DQB106 alleles were expressed more frequently in patients with only pulmonary involvement compared to those with extrapulmonary involvement. Conversely, HLA DQA101 was expressed more frequently in patients with extrapulmonary involvement. No statistically significant difference in the expression of HLA DRB1, HLA DQB1, and HLA DQA1 alleles was observed between sarcoidosis patients with and without cardiac involvement.

Conclusion:
Our findings suggest that HLA DQB103 and HLA DQB106 alleles might be protective against extrapulmonary organ involvement, while HLA DQA101 could be a risk factor. These findings may contribute to the prediction of treatment response and prognosis in sarcoidosis patients.
Acquired tracheoesophageal fistula in an adult due to mango endocarp: a case report
Authors: Sapkota Ranjan , Luitel Prajjwol , Rayamajhi Shivani , Pandey Anupama , Thapa Anjila 
Published: February 2025

Introduction and importance:
Tracheoesophageal fistulas (TEF) resulting from foreign body (FB) ingestion often present late, leading to delayed diagnosis. To the best of our knowledge, this is the first reported case of TEF caused by the accidental ingestion of a mango endocarp in the English literature.

Case presentation:
A 27-year-old female was referred for persistent cough for 4 months, following accidental ingestion of a mango endocarp. She initially complained of short-lived throat pain, foreign body sensation, and difficulty swallowing. At our facility, imaging revealed a TEF at the T1 vertebral level. Intraoperative localization was achieved with a bronchoscope and the fistulous tract was dissected and excised. The esophagus and trachea were repaired in two and one layers, respectively, and a sternohyoid flap was mobilized to buttress the repairs. She had a smooth recovery, with normal swallowing and voice preservation, and remains asymptomatic at 2 years.

Clinical discussion:
Although the majority of esophageal FBs are uncomplicated, delayed presentations can lead to severe complications like bleeding, perforation, or TEF. In our case, the initial symptoms of throat pain and mild dysphagia might have been the result of an initial laceration by the mango endocarp or impaction resulting in ulceration. The ulcer might have eroded deep into the trachea causing a fistula due to delay in seeking care.

Conclusion:
Mango endocarp ingestion can be a rare cause of TEF in adults and has to be considered in an appropriate setting.
Leveraging Media Monitoring to Inform Targeted Health Communications for Adolescents, Older Adults, and LGBTQ+ People
Authors: Bonnevie Erika , Smith Sierra , Kapur Maddie , Smyser Joe , Castrucci Brian C. 
Published: February 2025

Objective:
This manuscript assesses how media monitoring can guide the tailoring of public health communications for adolescents, older adults, and LGBTQ+ individuals, addressing their unique mental health challenges.

Design:
The study employed a thematic analysis of publicly available digital and social media data.

Setting:
Research was conducted using media monitoring platforms, with a focus on conversations relevant to specific groups within the United States.

Participants:
The dataset included millions of public posts relevant to mental health issues among adolescents, older adults, and LGBTQ+ communities, collected over a one-year period. Main Outcome Measures: Key themes and patterns within mental health discussions were identified.

Results:
Discussions around the “youth mental health crisis” were prominent, with 25% of adolescent-related posts reflecting this sentiment, often highlighting the impact of social media and academic pressures. For older adults, themes of loneliness and financial struggles were recurrent, with discussions showing a lack of practical support and resources. In LGBTQ+ conversations, there was an emphasis on the challenges of discrimination and identity-related misconceptions, with 28% of the mentions relating to mental health crises involving suicide or self-harm. These discussions underscored the critical need for inclusive and affirmative support tailored to the unique challenges faced by these groups.

Conclusions:
Media monitoring provides essential insights that can improve public health messaging by identifying trending mental health discussions and sentiments. By acknowledging and addressing the specific needs and challenges of specific population groups, public health communicators can develop more effective strategies that not only highlight problems but also offer clear, actionable solutions to promote better mental health outcomes and support. This approach is crucial for adapting health communications to the evolving landscape of media and public discourse, ensuring that messages are both relevant and supportive.
Outcomes of Kidney Transplantation From Donors on Renal Replacement Therapy
Authors: Goussous Naeem , Alghannam Karima , Than Peter A. , Wang Aileen X. , Chen Ling-Xin , Alexopoulos Sophoclis P. , Sageshima Junichiro , Perez Richard V. 
Published: February 2025

Background.
The increasing demand for organs has pushed transplant providers to expand kidney acceptance criteria. The use of kidneys from donors with AKI has been shown to provide good long-term graft survival. We aim to evaluate and compare the outcomes of deceased donor kidney transplantation from donors with acute kidney injury (AKI), either with or without renal replacement therapy (AKI-RRT) before donation.

Methods.
A single-center retrospective review of all patients who underwent deceased donor kidney transplantation from AKI donors between 2009 and 2020 was performed. AKI donors were defined on the basis of donor terminal creatinine ≥2.0 mg/dL or use of RRT before donation. We compared the outcomes of recipients receiving a kidney from a donor with AKI versus AKI-RRT. Data are presented as medians (interquartile ranges) and numbers (percentages).

Results.
Four hundred ninety-six patients were identified, of whom 300 (60.4%) were men with a median age of 57 y at transplantation. Thirty-nine patients received an AKI-RRT, whereas 457 received an AKI kidney. Donors in the AKI-RRT group were younger (28 versus 40), had less incidence of hypertension (15.3% versus 31.9%), and were more likely to be imported (94.9% versus 76.8%). There was a higher incidence of delayed graft function (72% versus 44%, P < 0.001) in the AKI-RRT group. Recipients in both groups had similar 90-d (100% versus 95.2%) and 1-y (100% versus 91.9%) graft survival. With a median follow-up of 5 y, there was no difference in death-censored graft survival in both groups (P = 0.83).

Conclusions.
Careful selection of kidneys from donors with AKI on RRT can be safely used for kidney transplantation with favorable clinical outcomes.
Nurses’ use of the five rights of medication administration in a comprehensive care unit: a best practice implementation project
Authors: Smith Jaclyn M. , Upchurch Linda 
Published: February 2025

Abstract

Introduction:
The “five rights” of medication administration are used by nurses daily to prevent patient medication errors. The five rights of medication administration are the right patient, drug, route, dose, and time. In the United States alone, between 7,000 and 9,000 medication administration errors occur annually. Internationally, medication errors are a leading cause of injury and harm.

Objectives:
This project aimed to improve compliance with medication administration rights in a comprehensive care unit among nurses in the acute care hospital setting.

Methods:
This project was conducted using an audit and feedback strategy, as recommended by the JBI Evidence Implementation Framework. Included in the project was the use of the JBI Practical Application of Clinical Evidence System (PACES) for pre- and post-audit data analysis and the JBI Getting Research into Practice (GRiP) approach to identify barriers, strategies, and outcomes. The project identified eight best practice criteria for medication administration to be used by nurses, including the five rights. After the baseline audit, barriers were identified, and educational interventions were implemented to improve adherence to best practices. A follow-up audit was conducted, and the results of both audits were compared.

Results:
In the baseline audit, two of the eight criteria, including checking the expiry date of medication and verbal identification of patient identifiers, were found to have lower adherence. Nursing staff education and visual reminders were implemented. A post-implementation audit was conducted, showing improved compliance with medication administration best practices.

Conclusions:
Staff education and visual reminders for best practices improved adherence to the five rights of medication administration. Annual competency training to reinforce best practices will prevent the incidence of medication errors, thereby maintaining quality and safety in patient care.

Spanish abstract:

http://links.lww.com/IJEBH/A321
Use of Electroconvulsive Therapy in a University Psychiatric Hospital in Brazil
Authors: Pereira-Soares Elaine Loureiro , Nascimento Antonio Leandro , dos Santos Gabriel Caetano , Horato Natia , Nardi Antonio Egidio 
Published: February 2025

Objectives
The aim of the study were to describe the practice of electroconvulsive therapy (ECT) at the Institute of Psychiatry (IPUB) of the Federal University of Rio de Janeiro (UFRJ) from 2015 to 2019 and to compare it with previous years at the same institute and with international practices.

Methods
Sociodemographic and epidemiological data, along with information on ECT and anesthetic techniques, were collected from the medical records of all patients who received ECT at IPUB-UFRJ between 2015 and 2019.

Results
A total of 238 patients underwent 4110 ECT sessions during the study period. A slight predominance of female patients (55.9%) was observed. Most patients were aged between 21 and 40 years (46.2%). Over half of the patients were outpatients (63.4%), with bipolar affective disorder being the most common diagnosis, accounting for 35.7% of ECT indications. Consent for ECT was obtained from all patients. Most treatments (85.2%) were conducted during the acute phase of illness. The average number of ECT sessions per patient was 5.4. All patients received anesthesia, and no deaths or severe complications related to ECT occurred. Monitoring cognitive effects and discharge criteria were the responsibility of the attending physician.

Conclusions
The practice of ECT at IPUB-UFRJ adhered to both local and international guidelines. There has been a notable shift in the utilization patterns of ECT at the institute compared to previous years. Standardized monitoring of cognitive effects and discharge criteria remains essential.
Antimicrobial resistance patterns of isolates from bloodstream infections at Jinja Regional Referral Hospital in Uganda
Authors: Lwigale Fahad 
Published: February 2025

Background:
Bloodstream infections (BSIs) are common acute syndromes of variable origin with high chances for extreme health effects including death. Empirical therapy is usually employed to manage the BSIs despite the high resistance to the antibacterial agents used including cefriaxone and/or metronindazole. This study determined the aetiologic agents responsible for bloodstream infections, their antimicrobial susceptibility patterns, and infection sources in Eastern-central Uganda.
Patients and methods:
This retrospective cross-sectional study involved analysis of data from all non-duplicate blood culture reports from 2019 to 2021. These were earlier generated using single set blood culture, conventional microbiology techniques and disc diffusion-based antimicrobial susceptibility testing (AST) guided by the Clinical and Laboratory Standards Institute (CLSI) guidelines. World Health Organization Network (WHONET) 2022 desktop software and Microsoft Excel were utilised for data analysis.
Results:
The 1364 reports showed a diagnostic yield of 6.8% (93/1364) and a 1.5%(21/1364) contamination rate. Overall, 37% and 13% of infections were hospital-acquired and community-acquired respectively. Most etiologic agents were Gram-positive bacteria dominated by Staphylococcus aureus 39/114 (34.2%). Polymicrobial growth existed in 4/1364(0.3%) cases. Staphylococcus aureus was mainly resistant to penicillin G (100%) and most susceptible to gentamicin (%S=74.1, 95% C.I:53.4-88.1). Escherichia coli and unspecified Coliforms together showed high resistance to ampicillin (87.5%) and third-generation cephalosporins (100%). The least resistance was to chloramphenicol and carbapenems.
Conclusion:
Staphylococcus aureus highly sensitive to gentamicin was the commonest cause of BSIs in this setting. Therefore, empirical management of suspected BSI cases in the region should include gentamicin. Use of Microbiology services including culture and sensitivity to guide targeted antimicrobial use and monitor resistance trends is required to strengthen antimicrobial stewardship.