bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of length of hospital stay on infection and readmission after minimally invasive hysterectomy
Authors: Schiff Lauren D. , Voltzke Kristin J. , Strassle Paula D. , Louie Michelle , Carey Erin T. 
Published: March 2019

AbstractObjectiveTo assess the effect of length of hospital stay on postoperative outcomes after minimally invasive hysterectomy.MethodsA retrospective cohort analysis was conducted of women who underwent minimally invasive hysterectomy (vaginal or laparoscopic) for benign conditions between January 1, 2014 and December 31, 2016, using the American College of Surgeons National Surgical Quality Improvement Program database. Patient information and 30‐day outcomes were compared using multivariable logistic regression after adjusting for patient demographics and medical and procedure variables.ResultsThe analysis included 31 347 patients. Women discharged the day after surgery were more likely to be African‐American, older, have prior abdominal surgery, and a higher ASA classification. Prevalence of organ space infection and readmissions were lower in the same day discharge group. No differences between same‐ and next‐day discharge were found for surgical site infection or urinary tract infection (adjusted odds ratios (aORs) 0.83 (95% [CI] 0.65–1.07; P=0.156) and 0.85 (95% CI 0.68–1.06; P=0.151), respectively). Same‐day hospital discharge was associated with a reduced chance of readmission (aOR=0.68, 95% CI 0.54–0.87; P=0.002).ConclusionSame‐day hospital discharge after minimally invasive hysterectomy lowered the risk of readmission and did not increase the risk of postoperative complications.
Expanding the Donor Pool With the Use of Extended Criteria Donation After Circulatory Death Livers
Authors: Mihaylov Plamen , Mangus Richard , Ekser Burcin , Cabrales Arianna , Timsina Lava , Fridell Jonathan , Lacerda Marco , Ghabril Marwan , Nephew Lauren , Chalasani Naga , Kubal Chandrashekhar A. 
Published: March 2019

Use of donation after circulatory death (DCD) donor livers for transplantation has remained cautious in the United States. The aim of this study was to demonstrate the expansion of a DCD liver transplantation (LT) program with the use of extended criteria donor (ECD) DCD livers. After institutional review board approval, 135 consecutive DCD LTs were retrospectively studied. ECD DCD livers were defined as those with 1 of the following factors: donor age >50 years, donor body mass index >35 kg/m2, donor functional warm ischemia time >30 minutes, and donor liver macrosteatosis >30%. An optimization protocol was introduced in July 2011 to improve outcomes of DCD LT, which included thrombolytic donor flush and efforts to minimize ischemia times. The impact of this protocol on outcomes was evaluated in terms of graft loss, ischemic cholangiopathy (IC), and change in DCD LT volume. Of 135 consecutive DCD LTs, 62 were ECD DCDs. In total, 24 ECD DCD LTs were performed before (era 1) and 38 after the institution of optimization protocol (era 2), accounting for an increase in the use of ECD DCD livers from 39% to 52%. Overall outcomes of ECD DCD LT improved in era 2, with a significantly lower incidence of IC (5% versus 17% in era 1; P = 0.03) and better 1‐year graft survival (93% versus 75% in era 1; P = 0.07). Survival outcomes for ECD DCD LT in era 2 were comparable to matched deceased donor LT. With the expansion of the DCD donor pool, the number of DCD LTs performed at our center gradually increased in era 2 to account for >20% of the center's LT volume. In conclusion, with the optimization of perioperative conditions, ECD DCD livers can be successfully transplanted to expand the donor pool for LT.
Evaluating the Association Between Tectonic Tremors and Earthquakes in Taiwan From 7 Years Catalogs
Authors: Peng Wei , Chen Kate Huihsuan , Toda Shinji 
Published: March 2019

AbstractKnowledge of what governs the interaction between slow‐ and fast‐slip earthquakes is essential to understanding the nature of the earthquake cycle. In southern Taiwan, four major earthquakes (2008Mw5.2 Taoyuan, 2010Mw6.4 Jiashian, 2012Mw5.9 Wutai, and 2016Mw6.4 Meinong events) that occurred near the active tremor areas provide a unique opportunity to analyze their spatiotemporal association. With the declustered tremor catalog built in this study, we were able to statistically evaluate the possible association between tremor and mainshock‐aftershock sequences in space and time. We found that close‐by mainshocks influences tremor's timing in a matter of less than 5 days by short‐term triggering, while the 2010ML6.4 Jiashian earthquake appears to be most responsible for such triggering. Assuming a low dip angle thrust faulting mechanism, tremors coincided with small static stress increases (8 kPa) in the 2010ML6.4 Jiashian earthquake. The other three major events, however, caused either negative or neglectable stress changes in the tremor zone. The different responses of the tremors can be explained by coseismic slip‐induced static stress change. In this complex tectonic region as a boundary between continental subduction and collision, the interaction between slow‐ and fast‐slip phenomena could be facilitated by a commonly high fluid pressure environment.
Commemorating Failure: Unsuccessful Rescue of Jews in German Film and Literature, 1945–1960*
Authors: Kabalek Kobi 
Published: March 2019

Abstract
Scholars have so far interpreted postwar depictions of Germans saving Jews from Nazi persecution mainly as apologetic references that allowed Germans to avoid addressing problematic aspects of their history. Yet although such portrayals appear in many postwar German accounts, depictions of successful rescues of Jews are relatively rare in literary and filmic works produced between 1945 and the early 1960s. This article argues that in presenting failed rescue of Jews, several German authors aimed to contribute to the re-education and moral transformation of the German population. The article’s first part shows that narratives of failed rescue were considered particularly useful for arousing Germans’ empathy with the Nazis’ Jewish victims. The article’s second part examines those works that went further and tailored stories of unsuccessful rescue to criticize Germans for not doing more to resist the regime. Although these works presented Germans as victims, as was common in many contemporaneous depictions, it would be misleading to view them merely as apologetic accounts. Rather, the widespread reluctance to commemorate the persecution of Jews urged several authors to retain the common image of Germans as victims in order to avoid alienating their audience. At the same time, using narratives of failed rescue, these writers and filmmakers explored new ways to allow Germans to speak about the Holocaust and reflect on their conduct. Attempts to both arouse a moral debate and avoid directly speaking about Germans’ collective responsibility might seem irreconcilable from today’s perspective, but not for Germans of the 1940s and 1950s.
Responding to Interpersonal Political Disagreement
Authors: Hopmann David Nicolas , Bjarnøe Camilla , Wonneberger Anke 
Published: March 2019

AbstractA key element of democracy is citizens exchanging viewpoints on political matters. Yet, we know little about how individuals respond to interpersonal political disagreement with peers: do they avoid it or yield, try to dominate others, or seek compromise? Based on two surveys with random assignment to different political statements, we study how individuals respond to interpersonal political disagreement on party choice and issue disagreement. The results from both surveys show that individuals are more likely to yield and dominate when the level of political disagreement is at a respectively low and high level. Citizens are more willing to seek compromise at low and moderate levels of disagreement, while avoiding is unrelated to the level of political disagreement.
Impact of Health Insurance on Stage at Cancer Diagnosis Among Adolescents and Young Adults
Authors: Keegan Theresa H M , Parsons Helen M , Chen Yi , Maguire Frances B , Morris Cyllene R , Parikh-Patel Arti , Kizer Kenneth W , Wun Ted 
Published: March 2019

Abstract

Background
Uninsured adolescents and young adults (AYAs) and those with publicly funded health insurance are more likely to be diagnosed with cancer at later stages. However, prior population-based studies have not distinguished between AYAs who were continuously uninsured from those who gained Medicaid coverage at the time of cancer diagnosis.

Methods
AYA patients (ages 15–39 years) with nine common cancers diagnosed from 2005 to 2014 were identified using California Cancer Registry data. This cohort was linked to California Medicaid enrollment files to determine continuous enrollment, discontinuous enrollment, or enrollment at diagnosis, with other types of insurance determined from registry data. Multivariable logistic regression was used to evaluate factors associated with later stages at diagnosis.

Results
The majority of 52 774 AYA cancer patients had private or military insurance (67.6%), followed by continuous Medicaid (12.4%), Medicaid at diagnosis (8.5%), discontinuous Medicaid (3.9%), other public insurance (1.6%), no insurance (2.9%), or unknown insurance (3.1%). Of the 13 069 with Medicaid insurance, 50.1% were continuously enrolled. Compared to those who were privately insured, AYAs who enrolled in Medicaid at diagnosis were 2.2–2.5 times more likely to be diagnosed with later stage disease, whereas AYAs discontinuously enrolled were 1.7–1.9 times and AYAs continuously enrolled were 1.4–1.5 times more likely to be diagnosed with later stage disease. Males, those residing in lower socioeconomic neighborhoods, and AYAs of Hispanic or black race and ethnicity (vs non-Hispanic white) were more likely to be diagnosed at a later stage, independent of insurance.

Conclusions
Our findings suggest that access to continuous medical insurance is important for decreasing the likelihood of late stage cancer diagnosis.
Transcription factors involved in the regulatory networks governing the Calvin–Benson–Bassham cycle
Authors: Wang Longxin , Xie Jianbo , Du Qingzhang , Song Fangyuan , Xiao Liang , Quan Mingyang , Zhang Deqiang 
Published: March 2019

Abstract
Transcription factors (TFs) play crucial roles in the regulation of photosynthesis; elucidating these roles will facilitate our understanding of photosynthesis and thus accelerate its improvement for enhancing crop yield. Promoter analysis of 52 nuclear-encoded Populus tomentosa Carr. genes involved in the Calvin–Benson–Bassham (CBB) cycle revealed 706 motifs and 326 potentially interacting TFs. A backward elimination random forest (BWERF) algorithm reduced the number of TFs to 40, involved in a three-layer gene regulatory network (GRN) including 46 photosynthesis genes (bottom layer), 25 TFs (second layer) and 15 TFs (top layer). Phenotype–genotype association identified 248 single-nucleotide polymorphisms (SNPs) within 72 genes associated with 11 photosynthesis traits. Of the regulatory pairs identified by the BWERF (202 pairs), 77 TF–target combinations harbored SNPs associated with the same trait, supporting similar mechanisms of phenotype modulation. We used expression quantitative trait nucleotide (eQTN) analysis to identify causal SNPs affecting gene expression, identifying 1851 eQTN signals for 50 eGenes (genes whose expressions are regulated by eQTNs). Distribution patterns identified 14 eQTNs from seven TFs associated with eight expression levels of their downstream targets (defined in the GRN), whereas seven TF–target pairs were also identified by phenotype–genotype associations. To further validate the roles of TFs at the metabolic level, we selected 6764 SNPs from 55 genes (identified by GRN–association or GRN–eQTN pairs or both) for metabolic association, identifying variants within 10 TFs affecting metabolic processes underlying the CBB cycle. Our study provides new insights into the photosynthesis pathway in poplar and may facilitate understanding of processes underlying photosynthesis improvement.
Clinical significance and sonographic evolution of enlarged abdominal lymph nodes in children
Authors: Quitadamo Paolo , Giannetti Eleonora , Andreozzi Marialuisa , Mancusi Valeria , Caprio Maria Grazia , Brambilla Andrea , Esposito Francesco , Vallone Gianfranco , Siani Paolo , Staiano Annamaria 
Published: March 2019

AbstractAimPaediatric evidence about the clinical implications of enlarged abdominal lymph nodes (EALN) is not univocal. The main purpose of our study was to evaluate the clinical significance and the morphological evolution of enlarged abdominal nodes in children with recurrent abdominal pain.MethodsAll children with recurrent abdominal pain diagnosed with EALN were enrolled at the involved centres between September 2017 and June 2018. Number, size, localisation, shape and architecture of nodes were accurately recorded along with clinical and laboratory data at enrolment and after three and six months.ResultsA total of 38 children were enrolled. After the six‐month study period, 58% of them had lymph nodes reduced in size, 13% had unchanged lymph nodes, and 29% had lymph nodes increased in size. Overall, we observed a gradual, albeit slight reduction in the average size of enlarged nodes over the six‐month period. The extent of size changes was not correlated with any clinical parameter.ConclusionOur data suggest that EALN are a non‐specific finding, which is not worth a change in the diagnostic and therapeutic management of children with abdominal pain.
Low resistivity zones at contacts of igneous intrusions emplaced in organic‐rich formations and their implications on fluid flow and petroleum systems: A case study in the northern Neuquén Basin, Argentina
Authors: Spacapan Juan Bautista , D´Odorico Alejandro , Palma Octavio , Galland Olivier , Senger Kim , Ruiz Remigio , Manceda Rene , Leanza Hector Armando 
Published: March 2019

AbstractIgneous sills and laccoliths emplaced in sedimentary basins may significantly impact petroleum systems, both positively and negatively. Igneous intrusions provide heat to maturate regionally immature organic‐rich host rocks, act as fractured reservoirs hosting commercial accumulations of hydrocarbons, and form structures affecting fluid flow and trapping at different scales. Nevertheless, the petrophysical implications of igneous intrusions on their host rock are poorly known. In this study, we analyse 200 wells in the Río Grande Valley oil field, Neuquén basin, Argentina, where the main reservoirs are in fractured igneous sills. This dataset represents a globally unique possibility to characterize the igneous–host rock interaction using both wireline logs and core material. We identify a systematic Contact Low Resistivity Zone (CLRsZ) at both the upper and lower contacts of the sills emplaced in the organic‐rich Vaca Muerta and Agrio Formations. We characterize the nature of these CLRsZ and their petrophysical properties by integrating resistivity and gamma ray well logs, petrographic analyses, petrophysical tests and geochemical analyses. The low resistivity signal of the CLRsZ is dominantly carried by massive‐sulphide deposits, mainly pyrite, observed both in the host rock and the chilled margin of the sills. Well log images and porosity‐permeability analysis on core plugs show that both the sills and their associated CLRsZ can act as carrier for fluid flow and reservoir for hydrocarbons storage. The thickness of the upper and lower CLRsZ correlates linearly with the thickness of the sill, and the volume of both the upper and lower CLRsZ represents ca. 40% with respect to the volume of their associated sill. The thickness of the CLRsZ represents ca. 13% of the thickness of contact aureole induced by the sills. In the CLRsZ, a great proportion of kerogen was transformed to hydrocarbon, so that CLRsZ were restricted to the innermost contact aureole of the sills. Our results show that the CLRsZ can have major implications on fluid flow and should be considered in reservoir models in volcanic basins hosting sills emplaced in organic‐rich formations.
Maternal IgG impairs the maturation of offspring intrathymic IL‐17‐producing γδT cells: Implications for murine and human allergies
Authors: de‐Oliveira Marília G. , Lira Aline A. L. , Sgnotto Fábio R. , Inoue Amanda H. S. , Santos Ludimila S. , Nakamatsu Bernardo Y. , Duarte Alberto J. S. , Leite‐de‐Moraes Maria , Victor Jefferson R. 
Published: March 2019

AbstractBackgroundThe precise mechanism involved in the acquisition of the IL‐17+ profile of γδT cells, the ligands responsible for this change, and whether this default is acquired during intrathymic maturation need to be elucidated.ObjectiveThis study aimed to evaluate whether IL‐17‐producing γδT cells are present in the airways of tolerant offspring from allergen‐sensitized mothers and the possible implication of maternal IgG in the generation of these cells.MethodsFemale mice were immunized or not, and the allergic response, frequency of γδT cell subsets and cytokine production of the offspring were analysed by flow cytometry. The effects of passive in vivo transfer of purified IgG were investigated in offspring. A translational approach was employed to analyse γδT cells in the thymus and PBMCs from humans.ResultsMaternal immunization reduced the frequency of spontaneous IL‐17‐producing γδT cells in the thymus, spleen and lung of offspring. This effect was mimicked by the in vivo treatment of females with purified IgG. IgG directly interacted with γδT cell membranes. The modulatory effect of human IgG on human infant intrathymic and adult peripheral γδT cells showed similarities to murine γδT cells, which is rarely reported in the literature.Conclusions & Clinical RelevanceTogether, our results reveal that IgG from potentially tolerant atopic mothers can influence offspring thymic IL‐17‐producing γδT cell maturation. Furthermore, we suggest that IgG is an unprecedented modulatory factor of murine and human γδT cells. These observations may support the future development of IgG‐based immunoregulatory therapeutic strategies.
Addition of analysis of KRAS mutation or immunohistochemistry with MUC1 and carcinoembryonic antigen improves the diagnostic performance of fine needle aspiration cytology for the diagnosis of pancreatic carcinoma
Authors: Gómez‐Peñaloza Catalina , Serrano‐Arévalo Mónica L. , Villegas‐González Lidia F. , Flores‐Hernández Lorena , Lino‐Silva Leonardo S. , Ruiz‐García Erika B. , Diaz‐Chávez José 
Published: March 2019

BackgroundPancreatic adenocarcinoma (PAC) is a health problem because of high lethality, increasing incidence and the absence of an early diagnosis. Biopsy by fine needle aspiration guided by endoscopic ultrasound has allowed obtaining tissue for cytopathological analysis, but there are several problems with their interpretation. We aimed to compare the diagnostic performance of the cytopathological analysis with the addition of either an immunohistochemical (IHC) panel or the KRAS mutation for the diagnosis of PAC.MethodsWe evaluated 62 pancreatic lesions by fine needle aspiration guided by endoscopic ultrasound, applying an IHC panel with mucin (MUC)‐1, MUC4, carcinoembryonic antigen (CEA) and p53. All cases also had a KRAS mutation determination. Three cytopathologists blinded to clinical data and the KRAS status reviewed the cytology independently. We calculated diagnostic performances for the cytology alone, cytology+IHC and cytology+KRAS to show the best method to diagnose PAC.ResultsFrom 62 samples, 50 (80.6%) were PAC and 12 benign lesions. The cytopathological analysis correctly interpreted 26 malignant and 12 non‐neoplastic cases (sensitivity 52%, specificity 100% and diagnostic accuracy 61.3%). The KRAS mutation was present in 88% of PAC. The cytology+ KRAS mutation increased the sensitivity by 10% and the diagnostic accuracy by 8%. The sensitivity increased by 2% adding either MUC1 or CEA to the cytology, and the diagnostic accuracy by 10 or 18%, respectively.ConclusionThe addition of IHC either with CEA or MUC1 improved the diagnostic performance of the cytology alone to diagnose PAC. The cytology + IHC evaluation was superior to the cytology + KRAS mutation to diagnose PAC.
A novel imaging flow cytometry method for the detection of histone H4 acetylation in myeloid cells
Authors: Uitrakul Suriyon , Hutton Claire , Veal Gareth J. , Jamieson David 
Published: March 2019

AbstractBackgroundThe histone deacetylase inhibitor (HDACI) valproic acid has been shown to inhibit the growth of multiple paediatric tumour types and is well tolerated in a childhood cancer setting. The current study was designed to develop a novel imaging flow cytometry method for the detection of histone H4 acetylation in white blood cells obtained from childhood cancer patients treated with valproic acid.Materials and methodsHL‐60 cells and whole blood samples from healthy volunteers were incubated with valproic acid (0‐8 mM) for 0‐24 hours, with additional blood samples collected from ependymoma patients receiving valproic acid on the SIOP Ependymoma II clinical trial. An imaging flow cytometry method was developed using an ImageStream®χ flow cytometer, collecting 100 000 images per sample following excitation of PE tagged acH4 antibody and DAPI.ResultsThe mean percentage of acH4‐positive cells increased to a greater extent than increases in mean and median fluorescence intensity following incubation with valproic acid. Comparable results were observed for in vitro and ex vivo experiments, and the assay was shown to be appropriate for clinical sample analysis. Myeloid cells exhibited a smaller proportion of acH4‐positive cells than the lymphoid population, but a greater fold increase above basal levels.ConclusionsThe percentage of acH4‐positive myeloid cells has the potential to be used as a robust pharmacodynamic biomarker for the measurement of acH4 for HDACIs. The developed assay is now being utilised in a clinical trial involving the treatment of childhood ependymoma patients with valproic acid.
Pine branch of Araucaria angustifolia in horse bronchi: A series of four cases
Authors: Barussi F. C. M. , Bastos F. Z. , Zenni L. , Camargo C. E. , Michelotto P. V. 
Published: March 2019

SummaryHorses at pasture are susceptible to the aspiration of foreign bodies. In Curitiba, southern Brazil, four horses of different breeds and ages were examined with regards to a persistent cough that lasted for several months, fetid breath, and no fever. The animals were referred for bronchoscopic examination performed under sedation and tracheobronchial topical anaesthesia. Bronchoscopies in all four horses revealed a pine branch of the species Araucaria angustifolia, native to southern Brazil, in the lumen of a third to fifth generation bronchus. Complete removal of the branch was possible in one case using a polypectomy loop inserted through the biopsy channel of the bronchoscope. In two cases, partial removal was possible. In one case the branch was adhered to the swollen mucosa and could not be extracted; this animal is being kept at pasture with intermittent antibiotic treatment as necessary. In conclusion, foreign bodies consisting of pine branches in the tracheobronchial tree of horses may be more common than currently recognised, as Araucaria genus is present in other countries and should be suspected in horses with chronic coughing associated with fetid breath and a history of reoccurrence following symptomatic treatments.