bluuebunny/crossref_metadata_2025_split huggingface dataset:
Infographic text as a tool for organizing Russian-language educational discourse
Authors: Deryabina S. A. , Dyakova T. A. , Strelchuk E. N. , Feizer Z. I. 
Published: November 2024

Importance. The significance of the subject matter arises from the potential for organizing effec tive foreign language communication based on contemporary methods of educational materials’ visual representation, one of which is infographic – a relevant, authentic material that presents in formation in a concise and comprehensible form, integrating verbal and non-verbal elements.Materials and Methods. The following methods are used: analysis of academic research on the infographic text application in teaching foreign languages and practical experience generalization with the use of such materials in Russian as a foreign language. The research materials included academic papers that provided methodological justification for the infographics use as well as infographic materials available online and personal experience gained from utilizing infographic texts within the educational process.Results and Discussion. Based on the material analysis results on the topic, it is concluded that there is a significant potential for using infographic text with supporting structures in Russian as a foreign language teaching. In this regard, the theoretical knowledge necessary for a teacher to or ganize productive speech activity in a foreign language is described: the main stages of organizing work with infographics, the requirements for the of infographics content are listed.Conclusions. Infographic texts are valuable methodological material in teaching foreign lan guages, around which a foreign language educational discourse is built. Methodically, the tradi tional pre-text, pre-text and post-text tasks for working with the educational text should be orga nized competently. Here, support structures are important, which stimulate speech activity, con tributing to the effective work organization on the oral and written speech production based on a given algorithm.
Elections to the Second State Duma and the Orthodox clergy (based on the materials of the secular press)
Authors: Kalyuzhnaya O. V. 
Published: November 2024

Importance. The issue of the Orthodox clergy involvement in elections to the State Duma of the Russian Empire continues to be one of the most challenging and under-researched. The purpose of the study is to examine the response of secular periodicals to the Orthodox clerics involvement in the elections for the Second State Duma.Materials and Methods. The subject of the study is the perception of representatives from various socio-political backgrounds regarding the Orthodox clergy involvement in elections to the State Duma as presented in Soviet periodicals. The research has been conducted using methods of con tent analysis, comparative analysis, and typology, based on materials from leading periodicals published in the Russian Empire, both party-affiliated and non-partisan.Results and Discussions. It is revealed how representatives of various public figures treated the Orthodox clergy participation in the elections to the State Duma. The following key points are highlighted, which are discussed in the periodical press: the clergy role in the political process, the clergy participation in the parties’ activities, the attitude of priest G.S. Petrov, the Orthodox clergy and the results of the elections to the State Duma.Conclusions. The Orthodox clergy is seen as a significant factor in the election campaign. For right-wing publications, the priests acted as their allies, with the help of which it is planned to bring as many monarchists as possible to the Duma. At the same time, some representatives of the right-wing press are against the participation of priests in the elections. For the Cadets, the Social Democrats and the periodicals close to them, the priests acted as agents of the political will of the bureaucracy, which sought to increase the number of conservative-minded deputies in the Duma.
Pedagogia de Paulo Freire e tecnologias digitais na educação
Authors: Vieira Márcia de Freitas 
Published: November 2024

Paulo Freire, o Patrono da Educação Brasileira, sempre fomentou o uso das tecnologias digitais na educação, reconhecendo as demandas da sociedade contemporânea e as potencialidades dos recursos tecnológicos. Este artigo busca refletir sobre como a pedagogia desenvolvida por Paulo Freire vem sendo incorporada nos estudos realizados pela Comunidade Brasileira de Informática na Educação, a partir de uma revisão sistemática de literatura das produções científicas publicadas na revista Tecnologias, Sociedade e Conhecimento e no Portal de publicações da Comissão Especial de Informática na Educação. Grande parte dos estudos preocupa-se com questões de cunho humanista, com a profundidade e extensão das relações humanas como essenciais à construção de uma pedagogia autônoma e problematizadora, com o pensar crítico do educando-educador, e com o caráter autônomo e crítico do aprendiz, entre outras questões intensamente defendidas por Freire.
Teachers’ digital competencies for effective AI integration in higher education in Oman
Authors: Khalil Hanan , Alsenaidi Said 
Published: November 2024

This study explores the competencies required by digital teachers to effectively leverage AI in fostering a future-ready classroom environment. It delves into competencies essential for teachers to harness the potential of AI. A descriptive analytical approach was employed to extract the required AI competency list and determine its importance. The study involved 26 teachers from the University of Technology and Applied Science in Oman. These participants were requested to complete a questionnaire designed to gather relevant data. The findings provide a comprehensive checklist of competencies necessary for seamless AI-enhanced teaching and serve as a valuable tool for training and guiding future digital teachers. The study revealed no significant differences in the perceived importance of AI competencies between teachers with less than 10 years of practical experience and those with 10 years or more of experience. This paper concludes that continuous professional development and targeted training are essential for all teachers to develop the necessary skills for an AI-enhanced education environment. Moreover, the study emphasizes the need for educational institutions to prioritize AI competency development in teacher training. Finally, it highlights the importance of a supportive infrastructure to help teachers stay updated with rapid AI advancement in education.
Housing quality and suitability and older people’s use of formal and unpaid care: a process of de-optimisation?
Authors: Brimblecombe Nicola , Cartagena-Farias Javiera , Hu Bo , Stevens Madeleine , Rajagopalan Jayeeta 
Published: November 2024

Abstract

Good quality, suitable housing is an important part of preventing care needs, supporting people with care needs, and improving older people’s lives. However, many older people live in housing which is of poor quality and unsuitable for their needs; this is unequally distributed. While there is a developing literature on supported housing and long-term care, this is rather less on non-specialist housing, the type in which the vast majority of older people live. Informed by social determinants frameworks and the behavioural model of health service use, our mixed methods study sought to understand the relationship between housing condition and older people’s use of formal care or help from family and friends. Methods comprised secondary analysis of quantitative data from a large representative sample, the English Longitudinal Study of Ageing (2012/2013 to 2018/2019), and semi-structured in-depth interviews with 72 people aged 65 and older with care needs and/or their unpaid carers living in five localities in England. We found that poor quality or unsuitable housing can affect use of formal and/or unpaid care in two ways – indirectly through increasing or precipitating care needs thus necessitating help from another person, and directly through being a barrier to receiving care. Poor housing acting as a barrier to care use can result in unmet need for support.
Impact of Intra-Aortic Balloon Counterpulsation in Open-Heart Surgery: A Multivariate Analysis of Retrospective Observational Data
Authors: Sharma Sagar , Nah Jie Hui , Siddarth Venkateswaran , Lai Haoxing , Liang Shen , Ong Zhi Xian , Wu Duoduo , Luo Haidong , Chang Guohao , Kang Giap Swee , Kofidis Theo , Sazzad Faizus 
Published: November 2024

Abstract

Background
The use of intraaortic balloon pump (IABP) effectively reduces left ventricular afterload and significantly increases coronary perfusion pressure by raising aortic diastolic pressure. This study examined the short and medium-term outcomes of 22,540 adult cardiac surgical patients requiring an IABP.
Methods
From 2009 to 2018, 1114 patients (4.94%) undergoing open-heart surgery at a single tertiary cardiac hospital received IABP support and were included in this retrospective study. They were categorized into pre-operative (Group A, n = 577), intra-operative (Group B, n = 475), and post-operative (Group C, n = 62) IABP insertion groups.
Results
Cardiogenic shock occurred in 11.2% of cases, mainly in Group A. Hemodynamic instability (38.8%) drove IABP use in Groups A and C, while difficulty weaning from CPB was the primary reason in Group C. The overall operative mortality rate was 10.9%, highest at 25.8% postoperatively. Multivariate analysis identified significant predictors of mortality: age (OR: 1.067, 95% CI: 1.041–1.094, p < .001), higher BMI (OR: 1.071, 95% CI: 1.017–1.128, p = 0.009), pulmonary hypertension (OR: 2.085, 95% CI: 1.302–3.341, p = 0.002), renal disease (OR: 2.780, 95% CI: 1.556–4.967, p < .001), and cardiogenic shock (OR: 3.684, 95% CI: 2.066–6.569, p < .001). Complications were more common in Group C, especially with renal disease. Average preoperative and postoperative stays were 4.0 ± 4.8 days and 15.2 ± 20.4 days, respectively, with no significant differences between groups.
Conclusion
IABP might offer safety for open-heart surgery, with longer hospital stays potentially associated with high-risk patients. Pre-operative IABP prophylaxis could be crucial in high-risk open-heart cases to reduce mortality.
Ovarian function measures in normogonadotropic anovulation and subclinical thyroid dysfunction: a prospective cohort study
Authors: Gawron Iwona , Baran Rafal , Jach Robert 
Published: November 2024

Abstract

Purpose: To compare ovarian function measures in euthyroid women with normogonadotropic anovulation in subclinical hypothyroidism (SCH) or thyroid autoimmunity (TAI) to those without thyroid dysfunction.
Design: A prospective open-label cohort study analyzed anti-Müllerian hormone (AMH), follicle-stimulating hormone (FSH), luteinizing hormone, estradiol and testosterone concentrations, ovarian volume, and polycystic ovarian morphology (PCOM) incidence between women with and without SCH or TAI in two study arms: polycystic ovary syndrome (PCOS) and hypothalamic-pituitary-ovarian dysfunction (HPOD).
Results: The prevalence of circulating thyroid peroxidase antibodies (TPOAb) was higher in the PCOS compared to the HPOD arm (p=0.006). No significant differences in the measured parameters were observed based on SCH or TAI status across the entire cohort or individual study arms, except for phenotype D of PCOS, where a greater volume (p=0.031) and higher incidence of physiological lesions (p=0.047) in the left ovary were noted in SCH, and phenotype A, where LH concentrations (p=0.038) were significantly higher in women without TAI. In the PCOS arm, thyroglobulin antibodies (TGAb) concentration correlated negatively with FSH (p=0.049) and positively with testosterone (p=0.012) concentrations, while in the HPOD arm, TPOAb and FSH concentrations were negatively correlated (p=0.028).
Conclusions: No clinically significant impact of SCH on ovarian function measures was demonstrated. Regarding TAI, significant correlations with still uncertain clinical significance were observed with FSH concentrations, both in PCOS and in HPOD. In view of the obtained results, the benefits of thyroxine supplementation to address menstrual irregularities and improve obstetric outcomes in the examined conditions, require support with clinical evidence.
Ascitic Shear Stress Activates GPCRs and Downregulates Mucin 15 to Promote Ovarian Cancer Malignancy
Authors: Mehta Geeta , Horst Eric , Cotter Liam , Bonini Mia , Novak Caymen , Treacher Nina , Zhang Yeye , Jackson Zoe , Narayanan Ishwarya Venkata , Wuchu Fulei , Nenwani Minal , Fischer Zachary , Sunshine Alec , Lin Zequan , Tran Linh , Nagrath Deepak , Ljungman Mats , Maturen Katherine , DiFeo Analisa , Nordsletten David 
Published: November 2024

Abstract

The accumulation of ascites in patients with ovarian cancer increases their risk of transcoelomic metastasis. Although common routes of peritoneal dissemination are known to follow distinct paths of circulating ascites, the mechanisms that initiate these currents and subsequent fluid shear stresses are not well understood. Here, we developed a patient-based, boundary-driven computational fluid dynamics model to predict an upper range of fluid shear stress generated by the accumulation of ascites. We show that ovarian cancer cells exposed to ascitic shear stresses display heightened G protein-coupled receptor mechanosignaling and the induction of an epithelial to mesenchymal-like transition through p38α mitogen-activated protein kinase and mucin 15 modulation. These findings along with a shear-induced immunomodulatory secretome position elevated shear stress as a protumoural signal. Together, this study suggests inhibition of the Gαq protein and restriction of ascites accumulation as maintenance strategies for overcoming mechanotransduction-mediated metastasis within the peritoneal cavity.
Single-cell transcriptomics reveals the landscape of esophageal squamous cell carcinoma after neoadjuvant chemoradiotherapy and the potential resistance role of LGALS1
Authors: Yan Qihang , Chang Wuguang , Li Zhenguo , Wong Wingshing , Gong Li , Liang Dachuan , Yang Jie , Dai Shuqin , Wang Junye 
Published: November 2024

Abstract

Background
Neoadjuvant chemoradiotherapy (neoCRT) remodels the tumor microenvironment in esophageal squamous cell carcinoma (ESCC). This study aimed to analyze the impact of neoCRT on the immune landscape of ESCC and identify potential resistance genes using single-cell RNA-seq (scRNA-seq).
Methods
We obtained scRNA-seq datasets of ESCC from the GEO database and evaluated changes in the number and function of key T cells and myeloid cells following neoCRT. Malignant epithelial cells were analyzed using inferCNV and subjected to differential analysis to identify potential drug-resistance genes. The gene LGALS1, implicated in drug resistance, was further investigated. The effects of short hairpin RNA knockdown of LGALS1 on cisplatin sensitivity were assessed both in vitro and in vivo. Additionally, potential resistance pathways were explored through a protein-protein interaction network and gene set enrichment analysis.
Results
NeoCRT treatment resulted in the activation of T cells and myeloid cells within the tumor microenvironment, enhancing the anti-tumor immune response and improving tumor cell eradication compared to the surgery group. However, neoCRT simultaneously increased LGALS1 expression in tumor cells, which contributed to the development of drug resistance. Mechanistically, LGALS1 overexpression was associated with increased platinum resistance, enhanced DNA repair, resistance to apoptosis and epithelial-mesenchymal transition.
Conclusion
scRNA-seq analysis revealed that neoCRT significantly alters the immune landscape of ESCC. While neoCRT activates T cells and myeloid cells to target tumor cells effectively, it also induces LGALS1 overexpression, which contributes to drug resistance and potential relapse.
Steering Drilling Wellbore Trajectory Prediction Based on the NOA-LSTM-FCNN Method
Authors: Gao Yi , Wang Na , Li Fei 
Published: November 2024

Abstract

Aiming at the problem that it is difficult to accurately predict wellbore trajectory under complex geological conditions, the NOA-LSTM-FCNN prediction method for steering drilling wellbore trajectory is proposed by combining nutcracker optimization algorithm (NOA), long short-term memory network (LSTM) and fully connected neural network (FCNN). This method adopts an LSTM layer to receive input data and capture long-term dependencies within the data, extracting important information. The FCNN layer performs nonlinear mapping on the output of the LSTM layer and further extracts relevant features to enhance prediction accuracy. NOA is employed for hyperparameter optimization of the LSTM-FCNN model. Through experimental validation, the proposed method has shown significant improvement in prediction accuracy and strong adaptability compared to traditional machine learning and deep learning methods. In addition, it applies to various types of wellbore trajectory data, effectively enhancing wellbore trajectory prediction capabilities under complex geological conditions.
Integrative morphological, phytochemical, and molecular identification of three invasive and medicinal Reynoutria species
Authors: Stafiniak Marta , Bielecka Monika , Kujawa Krzysztof , Jezierska-Domaradzaka Anna , Pencakowski Bartosz , Basiak Aleksander , Matkowski Adam , Nawrot-Hadzik Izabela 
Published: November 2024

Abstract

In Poland, knotweed is represented by three species – Reynoutria japonica Houtt., Reynoutria sachalinensis (F.Schmidt) Nakai, and a hybrid between two former species - Reynoutria x bohemica J. Chrtek & A. Chrtková. Brought to Europe as ornamental plants, R. japonica and R. sachalinensis began to appear outside of cultivation areas due to their impressive ability to propagate vegetatively by rhizome. Currently, all three are classified as highly invasive alien species. Rhizomes of R. japonica and R. sachalinensis are rich sources of biologically active compounds and have been used in traditional Chinese and Japanese medicine. However, only R. japonica is accepted as an herbal drug source in the pharmacopoeias (Polygoni cuspidati rhizoma et radix). There is no data on the medical use of Bohemian knotweed, but this hybrid species is frequently misidentified as R. japonica. Traditionally used morphological markers were, however, often reported as insufficient in raw material identification. Qualitative HPLC/DAD/ESI-HR-QTOF-MS analyses were used to determine the chemical composition of the collected Reynoutria samples. The UHPLC-QTOF-MS analysis revealed a total of 117 detected compounds belonging to carbohydrates, stilbenes, flavan-3-ols, procyanidins, anthraquinones, organic acids, and naphthalenes. Out of these, the abundance of 6 compounds was estimated quantitatively. Based on LC-MS data for 117 compounds, the cluster analysis dendrogram categorised the 15 accessions into two distinctive clusters, revealing unequivocal separation of the R. sachalinensis from other taxa representatives. This study intended to explore genetic identity, diversity, and population structure using sequence-related amplified polymorphisms (SRAP), and start codon targeted (SCoT) markers correlated with morphological traits and metabolic profiles in 15 collections of three knotweed taxa. Both the SCoT and the SRAP markers were located in the medium (0.1 to 0.25) or high (0.30 to 0.40) levels of PIC (polymorphic information content) and were considered as differentiating. Based on their polymorphic SRAP and SCoT fragments, the cluster analysis dendrogram categorized the 15 accessions into three distinctive clusters, closely referring to three knotweed taxa. The highest correlation between dendrograms was observed between genetic and morphological data, with values of 0.85 according to Baker’s methodology. Lower correlations were noted between genetics and metabolomics, and between morphology and metabolomics. The study suggests the effectiveness of morphological, phytochemical and molecular combinations employing SCoT and SRAP marker systems to assess the origin of plant material, and proves them useful for clarifying the population structure and assessing spread, diversity and evolution of the invasive species such as Reynoutria spp.
Comparative Analysis of Antifungal Properties and Metabolic Profiles in Seagrass Species from Rameshwaram Island, India
Authors: Ameen Hazeena M , Athira A S , Jayadev Ayona , Prasad Geena , Gayathri N P , Nair Deepa Indira 
Published: November 2024

Abstract

Seagrasses have gathered increasing attention due to their multifaceted ecological roles. Apart from their ecological significance, seagrasses have potent antifungal properties, indicating potential for diverse applications. The antifungal efficacy of methanolic extracts derived from five seagrass species (Cymodocea serrulata, Cymodocea rotundata, Halodule pinifolia, Halophila ovalis, and Syringodium isoetifolium) was assessed against selected pathogenic fungal strains using the agar well diffusion method. The methanolic extract from different seagrasses exhibited notable antifungal activity against Penicillium chrysogenum (Cymodocea serrulata- 19.5mm Halodule pinifolia- 19.9mm Halophila ovalis- 10.3mm Syringodium isoetifolium- 9.6mm). Least inhibition was noted to Candida albicans (Cymodocea serrulate - 4.6 mm, Cymodocea rotundata - 4.3mm and Halodule pinifolia - 6.5 mm). The findings show that methanolic extracts from seagrasses Cymodocea serrulata, Halodule pinifolia, and Enhalus acoroides at concentrations of 500µg and 1000µg exhibited remarkable inhibition of almost all pathogens under study. The samples exhibiting significant antifungal activity were subjected to metabolite profiling using GC-MS. A total of 23 compounds were identified in the methanolic extract of seagrass Cymodocea serrulata, while 25 compounds were detected in the methanolic extract of Halodule pinifolia. This study lays the groundwork for developing bioactive natural products with applications in phytosanitary practices, offering the additional advantages of environmental safety and economic viability. The ecology and the significance of seagrass ecosystems of Rameshwaram Islands is also shown in the manuscript.
Polysaccharide Lyase PL3.3 possibly potentiating Clostridium difficile clinical symptoms based on complete genome analysis of RT046/ST35 and RT012/ST54
Authors: Zhang Sen , Ma Wen , Zhang Xin , Cui Weitong , Liu Youhan , Tian Xuewen , Wang Qinglu , Luo Ying 
Published: November 2024

Abstract

Clostridium difficile has rapidly become a major cause of nosocomial infectious diarrhea worldwide due to the misuse of antibiotics. Our previous study confirmed that RT046/ST35 strain is associated with more severe clinical symptoms compared to RT012/ST54 strain. We conducted comprehensive genome identification of the RT046/ST35 and RT012/ST54 strains using whole-genome sequencing technology. The RT046/ST35 strain had a genome length of 7,869,254bp with a GC content of 29.49%. The original length of the RT012/ST54 strain was 7,499,568bp with a GC content of 29.64%. Additionally, we detected plasmid1 in the RT046/ST54 strain. We found that the RT046/ST35 strain had more genomic islands compared to the RT012/ST54 strain, and we identified polysaccharide lyase (PL) in the region around 2.2M. Furthermore, we discovered that the increased severity of clinical symptoms in the RT046/ST35 strain compared to the RT012/ST54 strain was unrelated to virulence factors and emphasized the potential crucial role of PL in RT046/ST35. There were almost no differences in eggNOG annotation and KEGG annotation between RT046/ST35 and RT012/ST54. RT046/ST35 had more mRNA processes in GO annotation. In conclusion, our study suggests that the core factor contributing to the more serious clinical symptoms of the RT046/ST35 strain compared to the RT012/ST54 strain is possibly PL.