bluuebunny/crossref_metadata_2025_split huggingface dataset:
Alliance for deep renovation in buildings. A step forward to the common European voluntary certification scheme
Authors: Zirngibl Johann , Mateo-Cecilia Carolina , Espigares-Correa Carlos 
Published: August 2019

The ALDREN project (ALliance for Deep RENovation in Buildings) is the extended development and the implementation of a common European Voluntary Certification Scheme (EVCS) for non-residential buildings based on the EPBD Art. 11 (9) and CEN / ISO standards. ALDREN is a coordination and support action (CSA). It focuses on existing tools and schemes (partly developed by the European Commission), on networking, standardization, awareness raising and communications.
The main goal of ALDREN is to encourage the construction sector value chain stakeholders to undertake deep renovation projects on their properties. Issuing completed and verified Energy Performance Certificates (EPC) before and after renovation, are to contribute to the development of innovative financial valuation of building assets and financing instruments (e.g. integrating loans with differentiated interest rates) and establishing business case for deep renovation to motivate private investment.
The core objectives of the ALDREN project are:
• To provide a harmonized European energy performance rating methodology based on the European Voluntary Certification Scheme (EVCS) verified by measurements to increase comparability, confidence and market uptake by standardized solutions (CEN/ISO standards) at European scale;
• To associate low energy renovation with high quality indoor environments to trigger renovation and to promote solutions supporting health and well-being;
• To align market recognition of high quality with enhanced building value and capacity building.
The ALDREN overarching outcome will be the infrastructure to enable market transformation for deep renovation and directly support the EU policies (EED, EPBD). Specific solutions and step-by-step renovation process will be integrated in a consistent, common way in a Building Renovation Passport (BRP). The ALDREN BRP will be aligned with the GABC (Global Alliance for Building and Construction) Building Passport initiative, seconded by DG Grow and DG Environment and with the current initiatives for residential buildings.
The non-residential sector (office buildings and hotels) is to be considered as a first step. To demonstrate the ALDREN approach , the upgraded EVCS will be implemented in pilot office buildings and hotels in different climates over the European territory. However, the ALDREN approach could be adapted to other market sectors, in a further development.
ALDREN renovation protocols may be used as individual modules in existing schemes or as standalone tool, being potentially overtaken by Member States of the European Union.
Energy retrofitting of a single-family house
Authors: Sánka Imrich , Petráš Dušan 
Published: August 2019

This article shows a real ongoing project called RenoActive, which is financed by company Velux. In cooperation with the company mentioned above an old single-family house was chosen to renovate. Three energy alternatives had been calculated: Standard, Comfort and Deluxe.
The thermal insulation system of the building is almost the same in all three alternatives. The alternatives mostly appear in the building services systems.
This article evaluates the energy consumption and investment differences between the alternatives.
Identification of the Retrofit Actions to Achieve Cost-Optimal and NZEB Levels for Residential Buildings in Istanbul Considering the Remaining Building Lifetime
Authors: Ganiç Sağlam Neşe , Yılmaz A. Zerrin , Corgnati Stefano P. 
Published: August 2019

Cost-optimal and nearly-zero energy building (NZEB) levels are two interrelated concepts identified for upgrading energy performance of buildings in Europe. In parallel, many research activities on retrofitting existing buildings in Turkey follow the methodology framework introduced by the European Commission. However, in Turkey, there is a process called “urban transformation” due to the earthquake risk, but the practice is based on new construction after demolishment of existing buildings. Especially in Istanbul, this process has been conducted rapidly. This specific aspect requires assessment of cost-optimal retrofit analyses considering the remaining lifespan of analysed buildings.
This study presents a cost-optimality assessment method for retrofitting towards NZEB in Turkey. The method integrates payback period and investment cost assessment to the methodology in order to obtain whole picture for retrofit alternatives. In the paper, suggested method is applied to a reference residential building in Istanbul. After the initial cost-optimal analyses, payback periods and initial investment costs for selected retrofit packages are assessed considering the future lifespan of the building. Together with these, possible subsidy opportunities are also investigated. Results show that, if the expected future lifespan is higher than 10 years, retrofit actions achieving 56.2kWh/m2y primary energy consumption level are considerable. Subsidies are beneficial to obtain reasonable initial investment costs.
An Approach to Improve Energy and Cost Performance of a Social Housing Archetype in Cold Climate Region
Authors: Yılmaz Yiğit , Yılmaz Burcu Çiğdem 
Published: August 2019

The importance of building energy performance has been substantially increasing in the last decades due to the global warming. Therefore, buildings within the existing stock and the new buildings are encouraged to achieve the energy performance restrictions and efficiency levels. In this context, a social housing archetype (Harct), which is constructed in each climate region of Turkey with a common design approach for temperate climate region, is evaluated as a base case to improve the energy performance for the cold climate region by the optimization of the life cycle cost (LCC). It is, namely, aimed to not only improve the energy performance of the archetype but also to ensure optimal cost efficiency as significant criterion.
It is focused to optimize the façades of the Harct in terms of window width, and optic and thermo-physical properties of the façade with determining the efficient insulation thickness level for exterior walls and efficient glazing types for windows. Firstly, façade design is analysed to find out the minimum and maximum windows’ widths to achieve the optimal window sizes. Secondly, optic and thermo-physical properties and cost data of the opaque and transparent façade elements have been designated among the market products in accordance with the current regulations. Energy model of the building has been run by Energy Plus simulation tool, in order to integrate it with GenOpt for optimization. Optimization was performed to carry out efficient frontier cases. The results were evaluated from life cycle cost (LCC) and energy efficiency point of view to highlight the cost optimal point
The Value of sustainability
Authors: Lewry Andy , Fisher James , Holden Matt 
Published: August 2019

As the market place becomes increasingly competitive and there is a need to be able to differentiate oneself as a high performer. Andrew Vaughan the CEO of Redevco stated‘Greening ourportfolio over the next two years is not only environmentally the right thing to do, it also makes soundbusiness sense.’Buildings built and/or managed to sustainability standards, such as BREEAM have been shown to minimise risk and generate maximum profit via:• High and continuous rental income;• Low operating & maintenance cost;• Low depreciation.UK valuers do not think we are paying a premium for green buildings but having to give a discount because the building is not performing well. This gives a convincing business case for new build where the certification process leads to a high-performance building.However, what about the existing building stock?Is the operational environmental performance of an asset reflected by its investment performance?This paper describes a new research project which aims to test the Hypothesis –Better operational performance in-use leads to improved investment performance of commercial offices. Improved operational performance goes “hand-in-hand” with environmental performance; where the performance can be illustrated by certification and labelling schemes.
Interlinking the effect of thermal mass and temperature control strategies in dwellings
Authors: Verbeke Stijn , Audenaert Amaryllis , Verhaert Ivan 
Published: August 2019

Exposed heavyweight constructions with a high specific heat capacity can dampen and delay transient heat flows in buildings. This paper explores the dynamic effects of various construction assemblies and explores the effect of different temperature control strategies in relation to the thermal mass. The thermal inertia of a building not only affects the pace of heating up a thermal zone, but also the temperature set-back that can be attained with an intermittent heating regime, and thus the setpoints of control regimes.
Based on a simulation study, it is demonstrated that the impact of the thermal mass on the heating demand of dwellings is rather limited in a temperate climate. Lightweight timber frame construction can display an annual heating energy demand of up to 6.6% higher compared to a heavy mass concrete and limestone construction in case of fixed thermostat setpoints. If a different control strategy with a highly intermittent thermostat schedule is implemented, the energy use of the lightweight construction can conversely have a lower heating energy expenditure, with a reduction of up to -4.5%. Modelling assumptions on the HVAC system capacity, the timing of the start-up moment of intermittent heating and the type of thermostat control – either based on air temperature or operative temperature – can have a significant influence on the simulation outcomes. Depending on the modelling assumptions and temperature control strategies implemented, the detailed dynamic simulations display that heavy mass buildings will not necessarily yield a lower heating demand as would be predicted by simplified monthly quasi-steady state calculations. In general, it is advocated that a better understanding of control strategies and resulting comfort sensations is required in building design and performance simulation.
Qualität und Struktur der ambulanten Versorgung von erwachsenen Patienten mit ADHS (Aufmerksamkeitsdefizit-/Hyperaktivitätsstörung)
Authors: Thome Johannes , Behnke Kerstin , Gleitz Markus , Steer Lydia , Weiher Martina , Hasford Joerg 
Published: August 2019

Zusammenfassung
Ziel der Studie Darstellung der Versorgungsrealität erwachsener ADHS-Patienten in der ambulanten Versorgung.
Methode Vollerhebung aller ambulanten GKV-Patienten ≥ 18 Jahre mit ICD-Code F90.0 für das Jahr 2012 im Freistaat Bayern.
Ergebnisse Die Diagnoseprävalenz betrug 0,1 %. Circa 30 % der Patienten erhielten nach Diagnosestellung ein für die Behandlung der ADHS im Erwachsenenalter zugelassenes Arzneimittel. Drei Viertel der medikamentös versorgten Patienten bekam die Verordnung von einem Facharzt für ZNS-Erkrankungen. Rund 50 % der Patienten erhielten auch psychotherapeutische Versorgung.
Schlussfolgerungen Da auch Hausärzte eine Rolle in der Versorgung von erwachsenen ADHS-Patienten spielen, sollte die Zusammenarbeit zwischen Fach- und Hausärzten sowie das Fortbildungsangebot verstärkt werden.
Update Therapie der ANCA-assoziierten Vaskulitiden
Authors: Holle Julia U. , Moosig Frank 
Published: August 2019

ZusammenfassungDieser Artikel gibt eine Übersicht über die aktuellen deutschen und europäischen Therapieempfehlungen zu den ANCA-assoziierten Vaskulitiden (AAV) sowie ein Update zu seither publizierten wichtigen Therapiestudien. Nach den deutschen und europäischen Empfehlungen erfolgt die Remissionsinduktion bei GPA/MPA mit organbedrohender Erkrankung mit Glucocorticoiden und Cycloposphamid oder Rituximab, bei nicht organbedrohender Erkrankung mit Glucocorticoiden und Methotrexat (MTX) oder Mycophenolat-Mofetil (MMF). Die kürzlich publizierte MYCYC-Studie unterstützt die Empfehlungen; sie zeigte eine Nicht-Unterlegenheit gegenüber i. v. Cyclosphamid bei GPA/MPA-Patienten mit nicht-organbedrohender und organbedrohender Erkrankung auf. Die remissionserhaltende Therapie soll mit niedrig-dosierten Glucocorticoiden sowie Azathioprin, MTX und Rituximab durchgeführt werden. Rituximab wurde Ende 2018 auf der Basis der MAINRITSAN-Studie als remissionserhaltende Therapie zugelassen und ist damit nun die formal einzige zur Remissionserhaltung zugelassene Therapie. Mehrere Studien zur untersuchten zudem die kurze Anwendung von Glucocorticoiden (z. B. durch additive Therapie mit Avacopan) in der Remissionsinduktion und das komplette Ausschleichen von Glucocorticoiden in der Remissionserhaltung. Die ersten Ergebnisse hierzu sind vielversprechend; Langzeitdaten stehen allerdings aus. Für die sehr viel seltenere EGPA liegen insgesamt deutlich weniger Studiendaten vor. Die Therapie wird jedoch im Wesentlichen nach den gleichen Prinzipien wie bei den anderen AAV durchgeführt. Neuerdings steht, in Deutschland für diese Indikation aber noch nicht zugelassen, eine Biologikatherapie mit dem Anti-IL-5-Antikörper Mepolizumab zur Verfügung.
Long-term Results of Conservative Therapy of Adolescent Idiopathic Scoliosis Using the Cheneau Brace
Authors: Weniger Carmen Dorothea , Fujak Albert , Hofner Benjamin , Fuchs Markus , Forst Raimund , Richter Richard Heinrich 
Published: August 2019

AbstractAdolescent idiopathic scoliosis is a disease of the growing skeleton. The goal in therapy is to decelerate or to prevent progression of the spinal curve. As part of a retrospective study the patient group of the scoliosis surgery from 1995–2016 was analysed according to the inclusion criteria of the Scoliosis research Society (SRS). 159 of 643 of the patients fullfilled the specific criteria. The assessment of effectiveness was based on the progression of the angle of curvature. If it was ≤5° it was judged positively. The therapy in accordance to Cheneau is a full-time bracing orthosis. Data from 159 patients – 136 fem. (85.5%), 23 male (14.5%) was analysed. The average age at the beginning of treatment was 13.3±1.7 years. The average duration was 3.47±1.2 years. The average Cobb-angle before treatment was 28.39°±9.44°. At the completion is was 27.7°±12.34°. Stabilisation of scoliosis (≤5°) was achieved for 136 of the patients (85.5%). The final follow-up showed a progression of the Cobb angel>5° in 23 cases, of which 19 had to undergo secondary surgery. The length of therapy had a positive influence (p=0.057) on the result. Brace treatment constitutes an effective method of therapy at curvatures between 20–40°. Short duration of therapy correlates with a expressively increased risk towards progression (p=0.057). The Cheneau brace treatment constitutes an effective treatment at curvature angles between 20–40°. The risk of progression can be reduced by a timely and correct identification.
Schwangerschaft bei chronisch-entzündlichen Darmerkrankungen
Authors: Roeb Elke 
Published: August 2019

ZUSAMMENFASSUNGDie höchsten gemeldeten Prävalenzraten für die chronisch-entzündlichen Darmerkrankungen (CED) Morbus Crohn und Colitis ulcerosa liegen aktuell in Europa. Etwa die Hälfte der Patienten sind Frauen und die meisten davon sind im reproduktionsfähigen Alter. Die Betreuung von schwangeren Patientinnen mit CED ist eine Herausforderung für interdisziplinäre Behandlungsteams. Die Auswirkungen der CED und ihrer Therapien auf Schwangerschaft, Neugeborene und Stillzeit sowie die Auswirkungen einer Schwangerschaft auf die CED und die Gesundheit der Mütter werden häufig mit Angst und Sorge betrachtet. Oft wird die Therapie bei Schwangerschaft und Stillzeit abgebrochen, ein signifikantes Risiko für eine Verschlechterung der Krankheitsaktivität und somit das größte bekannte Risiko für Schwangerschaft und Geburt. Frauen und Schwangere mit CED optimal zu betreuen erfordert eine interdisziplinäre Zusammenarbeit bei Diagnostik, Therapie und Prävention.
Mikrobiom und chronisch-entzündliche Darmerkrankungen
Authors: Klag Thomas , Wehkamp Jan 
Published: August 2019

ZUSAMMENFASSUNGDie Pathogenese chronisch-entzündlicher Darmerkrankungen ist durch genetische und Umweltfaktoren beeinflusst. Das Mikrobiom als Umweltfaktor der Darmbarriere steht zunehmend im Interesse der Forschung. Dieses Mikrobiom kann dabei nicht als eigenes Organsystem betrachtet werden, sondern wird durch die unspezifische Immunantwort des Darmepithels moduliert und gesteuert. Primäre und sekundäre Änderungen des Mikrobioms gehen fließend ineinander über und haben mögliche pathophysiologische und therapeutische Implikationen.
Atemwegsmanagement in Schwerelosigkeit
Authors: Hinkelbein Jochen , Schmitz Jan , Kerkhoff Steffen , Tochtermann Felix , Komorowski Matthieu , Neuhaus Christopher , Warnecke Tobias 
Published: August 2019

ZusammenfassungDas Ziel der vorliegenden Arbeit ist es, einen Überblick über den aktuellen Stand der Forschung zum Atemwegsmanagement in Schwerelosigkeit zu geben. Dafür wurde ein narratives Review von bisher publizierter Literatur über Atemwegsmanagement in (simulierter) Schwerelosigkeit erstellt. Mittels einer Suche in PubMed wurden 3 Originalarbeiten identifiziert, die das Atemwegsmanagement in Schwerelosigkeit untersucht haben. Alle 3 Studien wurden an menschlichen Modellen durchgeführt, 2 davon während Parabelflügen und eine Unterwasserstudie. Unter „Free-floating-Bedingungen“ war die Erfolgsrate zur Insertion eines supraglottischen Atemwegshilfsmittels (SGA) hervorragend (91–97 %). Die Erfolgsrate einer konventionellen Laryngoskopie war unter „Free-floating-Bedingungen” wesentlich schlechter und betrug 15–86 %. Die Sicherung des Atemwegs in Schwerelosigkeit scheint prinzipiell für eine Allgemeinanästhesie machbar. Hierbei ist es allerdings essenziell, dass der Anwender ausreichend gut trainiert ist und der Patient im Optimalfall fixiert ist. Die Verwendung eines SGA scheint in Schwerelosigkeit wesentlich einfacher zu sein.
Was hat die Ernährung mit der Wundheilung zu tun?
Authors: Renner R. , Erfurt-Berge C. 
Published: August 2019

ZusammenfassungBei einer Störung im Ablauf der Wundheilung kann es zu einem verzögerten oder fehlenden Wundverschluss kommen. Als ein möglicher Störfaktor gilt die Ernährung. Man muss zwischen quantitativer und qualitativer Mangelernährung unterscheiden. Gerade übergewichtige Patienten leiden oft an einer qualitativen Mangelernährung und Sarkopenie. Spezifische Erkrankungen machen eine entsprechende diätetische Nahrungsempfehlung notwendig. So findet man bei dialysepflichtigen Patienten, Dekubitus-Patienten und Ulcus cruris-Patienten oft einen Eiweißmangel. Auch niedrige Level an Vitamin C, Zink, Folsäure, Vitamin D oder Spurenelementen können die Wundheilung negativ beeinflussen. Größere prospektive Studien sollten klären, ob eine Substitution dieser Mangelzustände den gewünschten positiven Effekt auf die Wundheilung hat. Es erscheint aber sinnvoll, eine ausgewogene Ernährung und an die individuellen Ernährungsgewohnheiten angepasste Verbesserung der Aufnahme von Vitaminen, Spurenelementen und Eiweißen anzustreben.
Influence of Silybum Marianum on Morphine Addicted Rats, Biochemical Parameters and Molecular Simulation Studies on µ-Opioid Receptor
Authors: Malekshah Rahime Eshaghi , Khaleghian Ali 
Published: August 2019

AbstractThe present study aimed to investigate effects of medicinal plant (Silybum marianum) on the animals with treatment of morphine addiction compared to chemical drug (Naloxane). Also, this study was conducted to evaluate the role of Silybum marianum on factors of serum ALT, AST activities and activity of the antioxidant enzyme:superoxide dismutase (SOD) as well as the extent of lipid peroxidation of Morphine addicted rats.High performance liquid chromatography (HPLC) has been used to measure Morphine in the serum, enzymes functions well as lipid peroxidation of Morphine addicted animals. Results demonstrate treatment with S. Marianum for opium rats at dose 400 mg/kg led to a major reduction in serum morphine compared to Naloxane (400 mg/kg>200 mg/kg>100 mg/kg>Naloxane. The positive effect of dose-dependence on liver enzymes function (ALT and AST) in order of 400 mg/kg>Naloxane>200 mg/kg>100 mg/kg. Furthermore, the findings show that the malondialdehyde levels are increased in opium-treated animals. However, the extracts also demonstrate a significant reduction in the MDA levels compared to the control, 400 mg/kg>200 mg/kg>Naloxane>100 mg/kg. Increase of Silybum marianum extract in rats pretreated significantly elevated the activities of superoxide dismutase (SOD).At last, our data suggest that Silibinin as the main component found in Milk thistle is more selective toward µ-Opioid Receptor than Morphine and Naloxane as a narcotic receptor antagonist.
Behçet-Syndrom
Authors: Xenitidis Theodoros , Henes Joerg Christoph 
Published: August 2019

ZusammenfassungDas Behçet-Syndrom gehört zu den Vasculitiden variabler Gefäßgröße. Das klinische Bild ist sehr vielfältig und erfordert in der Regel eine interdisziplinäre Zusammenarbeit. Pathogenetisch scheint es eine Mittelstellung zwischen einer polygenetischen Autoinflammationserkrankung und einer autoimmunen Erkrankung einzunehmen. 2018 wurden neue EULAR-Empfehlungen herausgegeben. Die Therapie richtet sich nach der führenden Beteiligung der einzelnen Organe. Seit 2016 ist Adalimumab zugelassen für die Behandlung der hinteren Augenbeteiligung. Infliximab, Interferon a2a, Interleukin-1-Antagonisten und Apremilast können Therapiealternativen darstellen.
A Simple Retractor for Anterior Cervical Diskectomy
Authors: Eftekhar Behzad 
Published: August 2019

Abstract
Background The insertion of available cervical retractor systems is relatively complex for the limited exposure required for single-level anterior cervical diskectomy.
Objective To introduce a novel cervical retractor system and report the initial experience of its application.
Methods A simple retractor system was designed that is fixed to the vertebral body through Caspar pins. The design allows the retractor to move with the vertebrae during distraction via the traditional Caspar distractor system. The advantages and limitations of the device based on the initial experience are discussed.
Results The author has used the current version of the retractor on 32 single-level anterior cervical diskectomies. The insertion of the retractor is easy, and its application provides safe and satisfactory anterior cervical exposure. There have not been related complications, although transient dysphagia has not been prevented.
Conclusion This newly designed retractor system is simple and efficient for a single-level anterior cervical diskectomy, and its insertion is relatively easy.
Making a Good Hire
Authors: Gregory Laurel , Clark Deborah 
Published: August 2019

AbstractHiring the right employee is paramount to the success of any business. In 2019, with unemployment rates low and job openings high, hiring anyone might sound good. However, taking the time to find the right employee far outweighs the cost of replacing a bad or desperate hire. This article discusses the interviewing and onboarding process to shift the odds positively in the direction of making a lasting, good hire.