bluuebunny/crossref_metadata_2025_split huggingface dataset:
An adaptive memetic algorithm for feature selection using proximity graphs
Authors: Abu Zaher Amer , Berretta Regina , Noman Nasimul , Moscato Pablo 
Published: December 2018

AbstractWe propose a multivariate feature selection method that uses proximity graphs for assessing the quality of feature subsets. Initially, a complete graph is built, where nodes are the samples, and edge weights are calculated considering only the selected features. Next, a proximity graph is constructed on the basis of these weights and different fitness functions, calculated over the proximity graph, to evaluate the quality of the selected feature set. We propose an iterative methodology on the basis of a memetic algorithm for exploring the space of possible feature subsets aimed at maximizing a quality score. We designed multiple local search strategies, and we used an adaptive strategy for automatic balancing between the global and local search components of the memetic algorithm. The computational experiments were carried out using four well‐known data sets. We investigate the suitability of three different proximity graphs (minimum spanning tree, k‐nearest neighbors, and relative neighborhood graph) for the proposed approach. The selected features have been evaluated using a total of 49 classification methods from an open‐source data mining and machine learning package (WEKA). The computational results show that the proposed adaptive memetic algorithm can perform better than traditional genetic algorithms in finding more useful feature sets. Finally, we establish the competitiveness of our approach by comparing it with other well‐known feature selection methods.
Epidemiology and outcomes of dengue in kidney transplant recipients: A 20‐year retrospective analysis and comparative literature review
Authors: Pinsai Subencha , Kiertiburanakul Sasisopin , Watcharananan Siriorn P. , Kantachuvessiri Surasak , Boongird Sarinya , Bruminhent Jackrapong 
Published: December 2018

AbstractBackgroundKidney transplant (KT) recipients in dengue‐endemic areas are at risk of exposure. We investigated the epidemiology and outcomes from dengue inKTrecipients at our transplant center and conducted a literature review.Materials and methodsWe conducted a 20‐year retrospective study ofKTrecipients who were diagnosed with laboratory‐confirmed dengue from January 1997 to September 2017 according to the 2009 World Health Organization (WHO) classification. We analyzed clinical characteristics and treatment outcomes.ResultsThere were 13 (0.7%) dengue cases among 1917KTrecipients with a median age of 39 years (interquartile ranges [IQR], 22‐46); 54% were males. Cases occurred with a median onset of 24 months (IQR, 6‐122) afterKT. Dengue was diagnosed via dengueNS1 antigen (85%), IgM antibodies (38.5%), orRT‐PCR(15.4%). Patients were classified as having dengue without warning sign (30.8%), with warning sign (53.8%), or severe dengue (15.4%). All patients resolved without complications, except one had hemophagocytic lymphohistiocytosis. Ten (76.9%) patients experiencedeGFRreduction with a median of 13.7 mL/min/1.73 m2(IQR, 8.3‐20.5); eight (80%) had a full allograft function recovery.ConclusionsDengue inKTrecipients in endemic areas is uncommon. Although a transient decline in allograft function can occur, the overall clinical and allograft outcomes seem to be favorable.
Primary cutaneous vs secondary cutaneous follicular lymphomas: A comparative study focused on BCL2, CD10, and t(14;18) expression
Authors: Servitje Octavio , Climent Fina , Colomo Lluis , Ruiz Nuria , García‐Herrera Adriana , Gallardo Fernando , Mercadal Santiago , Pomares Helena , Muniesa Cristina , Martin‐Callizo Clara , Marcoval Joaquim , Rovira Roger , Estrach Teresa , Pujol Ramon M. 
Published: December 2018

BackgroundPrimary cutaneous follicular center‐cell lymphoma (PCFCL) is one of the most common types of cutaneous B‐cell lymphoma. Differences in immunohistochemical expression of BCL2 and CD10 antigens along with the presence of t(14:18) translocation in neoplastic cells have been postulated as relevant clues in differentiating PCFCL from cutaneous lesions secondary to a systemic follicular lymphoma (SCFL). The aim of this study is to evaluate the significance and usefulness of these parameters in a large series of patients.MethodsPatients with PCFCL and SCFL diagnosed at three university hospitals in Barcelona, from 2000 to 2015 were reviewed. Clinical, histopathological, immunophenotypical, genetic, and outcome parameters were analyzed.ResultsEighty‐one cases (59 PCFCL and 22 SCFL) were included. There were no significant differences between PCFCL and SCFL cases regarding clinical presentation, site of involvement, or predominant type of skin lesions. Most patients in both groups showed positivity for BCL2 and CD10, but strong expression of BCL2 and CD10 was associated with SCFL cases. Although more frequent in SCFL, a small proportion of PCFCL cases also showed the t(14:18) on FISH analysis.ConclusionThe intensity of BCL2 expression was found to be the single most valuable clue in differentiating PCFCL from SCFL cases on histopathological grounds.
Early clinical predictors of long‐term morbidity in major depressive disorder
Authors: Serra Giulia , Koukopoulos Athanasios , De Chiara Lavinia , Koukopoulos Alexia E. , Sani Gabriele , Tondo Leonardo , Girardi Paolo , Reginaldi Daniela , Baldessarini Ross J. 
Published: December 2018

AimsTo identify early clinical factors predictive of later morbidity in major depressive disorder (MDD).MethodsWe analysed factors associated with long‐term depressive morbidity (%‐time ill) between a first‐lifetime major depressive episode and last follow‐up of 116 adults diagnosed with DSM‐IV major depressive disorder. Bivariate comparisons were followed by multivariable linear regression modelling.ResultsThree factors were independently associated with an average of 25%‐time‐depressed over 17 years at risk: (a) agitated‐mixed, or psychotic features in initial major depressive episodes, (b) anxiety syndromes prior to a first‐lifetime major depressive episode, and (c) anxiety symptoms in childhood.ConclusionEarly anxiety symptoms and syndromes and agitated‐mixed or psychotic initial depressive episodes predicted more long‐term depressive morbidity in MDD.
Strategies to decrease social jetlag: Reducing evening blue light advances sleep and melatonin
Authors: Zerbini Giulia , Kantermann Thomas , Merrow Martha 
Published: December 2018

AbstractThe timing of sleep is under the control of the circadian clock, which uses light to entrain to the external light‐dark cycle. A combination of genetic, physiological and environmental factors produces individual differences in chronotype (entrained phase as manifest in sleep timing). A mismatch between circadian and societal (e.g., work) clocks leads to a condition called social jetlag, which is characterized by changing sleep times over work and free days and accumulation of sleep debt. Social jetlag, which is prevalent in late chronotypes, has been related to several health issues. One way to reduce social jetlag would be to advance the circadian clock via modifications of the light environment. We thus performed two intervention field studies to describe methods for decreasing social jetlag. One study decreased evening light exposure (via blue‐light‐blocking glasses) and the other used increased morning light (via the use of curtains). We measured behaviour as well as melatonin; the latter in order to validate that behaviour was consistent with this neuroendocrinological phase marker of the circadian clock. We found that a decrease in evening blue light exposure led to an advance in melatonin and sleep onset on workdays. Increased morning light exposure advanced neither melatonin secretion nor sleep timing. Neither protocol led to a significant change in social jetlag. Despite this, our findings show that controlling light exposure at home can be effective in advancing melatonin secretion and sleep, thereby helping late chronotypes to better cope with early social schedules.
Megapanorpa, a new genus with a single anal horn in males from Oriental China (Mecoptera: Panorpidae)
Authors: Wang Ji‐Shen , Hua Bao‐Zhen 
Published: December 2018

AbstractA new genus of Panorpidae, Megapanorpa gen. nov., is erected for five new species, Megapanorpa grandis sp. nov. (type species), M. absens sp. nov., M. gaokaii sp. nov., M. jiangorum sp. nov. and M. wanghongjiani sp. nov. This genus is similar to Cerapanorpa Gao et al., 2016 in a single anal horn on the sixth tergum of male, but can be differentiated from the latter by the following characters: the seventh abdominal segment of male is constricted and stalk‐like at base, the subgenital plate of female with a pair of lateral plates, and the medigynium of female with a concealed axis. Keys to genera of Panorpidae and species of Megapanorpa gen. nov. are presented. The morphology and function of anal horns in different genera and species have been discussed.
Effects of Self‐Discrepancy and Self‐Schema on Young Women's Body Image and Self‐Esteem after Media Image Exposure
Authors: Yu Ui‐Jeen , Jung Jaehee 
Published: December 2018

The purpose of this study was to examine how self‐discrepancy and self‐schema influence the effects of exposure to thin versus nonidealized model images on young women's body dissatisfaction, body anxiety, and self‐esteem as an antecedent and moderator. Female college students at a Midwestern university (n = 380) responded to a web‐based survey with stimuli that consisted of thin, nonidealized, and no model images in fashion ads. Results indicated appearance self‐discrepancy and self‐evaluative schema in appearance augmented body dissatisfaction and body anxiety, and decreased self‐esteem, whereas motivational schema in appearance reduced body anxiety and improved self‐esteem. There were no differences in body dissatisfaction, body anxiety, and self‐esteem from these three model stimuli. However, participants with higher appearance self‐discrepancy had greater body dissatisfaction and body anxiety when exposed to thin‐idealized model images rather than nonidealized model images. Self‐evaluative and motivational schema in appearance did not play a moderating role on the effects of exposure to thin versus nonidealized model images on body dissatisfaction, body anxiety, and self‐esteem. Appearance self‐discrepancy provides better insights for the effects of media on body image and self‐esteem than appearance self‐schema as a moderator.
Tamoxifen use correlates with increased risk of hip fractures in older women with breast cancer: A case–control study in Taiwan
Authors: Hung Shih‐Chang , Liao Kuan‐Fu , Hung Hung‐Chang , Lin Cheng‐Li , Lee Po‐Chang , Hung Shih‐Jung , Lai Shih‐Wei 
Published: December 2018

AimThis study aimed to evaluate the association between tamoxifen use and hip fractures in older women with breast cancer in Taiwan.MethodsWe carried out a retrospective nationwide case–control study using the database of the Taiwan National Health Insurance Program. A total of 762 female patients with breast cancer aged ≥65 years newly diagnosed with hip fractures from 2000 to 2011 were identified for inclusion in the study. Additionally, 7620 female patients with breast cancer aged ≥65 years without hip fractures were randomly selected as controls. Patients were defined as having used tamoxifen if they had an existing prescription for tamoxifen before the index date. Patients were defined as having never used tamoxifen if they had never been given a prescription for tamoxifen before the index date. We used an unconditional logistic regression model to calculate the odds ratio and 95% confidence interval for the association between tamoxifen use and risk of hip fractures.ResultsAfter adjustment for confounding variables, compared with patients who did not use tamoxifen, the adjusted odds ratio of hip fracture was 2.29 for those who had used tamoxifen (95% confidence interval 1.92, 2.72). Furthermore, adjusted odds ratios were 2.74 (95% confidence interval 2.19, 3.42) among patients with a cumulative duration of tamoxifen use of >3 years.ConclusionTamoxifen use is associated with increased risk of hip fractures among older women with breast cancer in Taiwan. Geriatr Gerontol Int 2019; 19: 56–60.
Effect of sonic versus manual supervised toothbrushing on both clinical and biochemical profiles of patients with desquamative gingivitis associated with oral lichen planus: A randomized controlled trial
Authors: Bianco Laura , Romano Federica , Maggiora Marina , Bongiovanni Loretta , Guzzi Nicoletta , Curmei Elena , Arduino Paolo Giacomo , Aimetti Mario 
Published: December 2018

AbstractObjectivesThe aim of this randomized, parallel‐design, clinical trial was to investigate the effectiveness of an intensive plaque control programme with sonic versus manual toothbrushing on clinical outcomes and gingival crevicular fluid (GCF) levels of matrix metalloproteinases (MMP) in desquamative gingivitis (DG) patients.MethodsA total of 32 patients affected by DG secondary to oral lichen planus (OLP) were consecutively recruited and randomly assigned to a test (n = 16) and control (n = 16) group. Both groups were enrolled in an intensive control programme comprising supragingival scaling and polishing, and brush‐specific instructions for a period of 8 weeks. The treatment of interest (test) was the use of a sonic‐powered toothbrush, and the standard treatment (control) was the utilization of a soft‐bristle manual toothbrush for twice‐daily home oral hygiene procedures. Periodontal parameters, patient‐centred outcomes, MMP‐1 and MMP‐9 GCF levels were evaluated at baseline and 8 weeks after starting the programme.ResultsThe plaque control programme resulted in statistically significant reduction in periodontal parameters with consequent improvement in the clinical features, painful symptoms and severity of DG lesions in both groups (all P < 0.001). When a sonic toothbrush was used, there was a more significant decrease in clinical indices, mucosal disease scores and GCF levels of MMP‐1 and MMP‐9.ConclusionsThis clinical trial reported the effectiveness of a combined protocol based on professional oral hygiene and supervised toothbrushing in OLP patients with DG. The daily use of a sonic toothbrush would seem to perform better in the short term.
CuO improved (Sn,Sb)O2 ceramic anodes for electrochemical advanced oxidation processes
Authors: Sánchez‐Rivera María‐José , Giner‐Sanz Juan José , Pérez‐Herranz Valentín , Mestre Sergio 
Published: December 2018

AbstractAntimony‐doped tin oxide electrodes with CuO as sintering aid are presented as an economical alternative to metal‐based electrodes, intended for the electrooxidation process of emerging and recalcitrant organic contaminants in wastewaters. The CuO proportion has been optimized to obtain densified electrodes with a mild thermal cycle (Tmax = 1200°C). One of the manufactured electrodes (97.8 mol.% of SnO2, 1.0 mol.% of Sb2O3, and 1.2 mol.% of CuO) was selected for electrochemical characterization from a physical and morphological analysis. The electrochemical behavior of the selected electrode showed that the addition of CuO as sintering aid widens the electrochemical window and increases the electrode “inactivity”, with respect to an (Sn, Sb)O2 electrode synthesized in the same conditions. In return, the (Sn,Sb,Cu)O2 electrode presents a significantly lower electrochemical rugosity factor. Moreover, the addition of CuO does not change the oxygen evolution reaction mechanism, but it modifies the kinetic parameters, leading to a larger accumulation of hydroxyl radicals. Consequently, the addition of CuO as sintering aid significantly improves the electrochemical properties of the electrode as an electrochemical advanced oxidation process anode with respect to the (Sn,Sb)O2 electrode, at the expense of worsening its electrochemical roughness factor. The results of the electrochemical characterization were confirmed by Norfloxacin degradation tests.
Dense phase carbon dioxide treatment of tomato juice: effect on physico‐chemical properties, phenolic composition, lycopene isomerisation and in vitro bioaccessibility
Authors: Zhao Wenting , Sun Yeting , Ma Yue , Zhao Xiaoyan 
Published: December 2018

SummaryThe effect of dense phase carbon dioxide (DP‐CO2) technology on tomato juice qualities was investigated. Results showed that DP‐CO2 treatment induced a significant decrease in pH and an increase in titratable acid. Flavour profile and apparent viscosity were more close to the control (untreated) as compared to the heat‐treated (95 °C for 20 min). Consumer acceptance test indicated that DP‐CO2 juices were more liked than the heat‐treated in flavour, taste and overall acceptability. DP‐CO2 treatments at 30 MPa for 40 and 60 min had positive effects on the content of phenolic compounds, including myricinic acid, ferulic acid, naringin and chlorogenic acid. A significant increase in the relative content of sum cis‐isomers was observed after DP‐CO2 treatment at 20 MPa. The in vitro lycopene bioaccessibility increased significantly after treatment at 20 MPa for 20, 40, 60 min as compared to the control and heat‐treated.
Co‐products of beef processing enhance non‐haem iron absorption in an in vitro digestion/caco‐2 cell model
Authors: O'Flaherty Elisabeth A. A. , Tsermoula Paraskevi , O'Neill Eileen E. , O'Brien Nora M. 
Published: December 2018

SummaryBeef processing produces high volumes of protein rich, low value, ‘waste’ co‐products such as offal. Beef improves uptake of low bioavailable non‐haem iron (found in vegetables, fortificants, supplements) and this effect is dubbed the ‘meat‐factor’, although the underlying mechanism is not fully understood. Here, we investigate whether bovine co‐products (kidney, lung, heart) not previously studied share this enhancing potential. This was determined by coupled in vitro digestion of co‐products and subsequent caco‐2 cell ferritin formation (an intracellular iron storage protein). In this study we show that bovine co‐products significantly increase caco‐2 cells’ response to non‐haem iron from infant rice cereal. The presence of these co‐products, (kidney, lung and heart), increased relative uptake (by 207.13%, 171.21%, 265.28%, respectively), to a greater extent than beef (30.23%). Our findings present a novel function for co‐products of beef processing that may have potential as food ingredients to improve non‐haem iron bioavailability, thus adding value.
The long‐term effect of previous dental treatment under general anaesthesia on children's dental fear and anxiety
Authors: Aldossari Ghadah S. , Aldosari Alanoud A. , Alasmari Amirah A. , Aldakheel Rwan M. , Al‐Natsha Reem R. , Aldossary Mohammed S. 
Published: December 2018

BackgroundDental treatment under general anaesthesia (DGA) is deemed to contribute to children's dental fear and anxiety (DFA), both in the short term and long term.ObjectiveTo compare DFA between children who had previous DGA and those who did not.MethodsA cross‐sectional survey included 5‐ to 12‐year‐old children who had undergone DGA (n = 43) and a control group who had not (n = 55). Questionnaires were completed by parents regarding sociodemographic and dental profiles. Children's Fear Survey Schedule‐Dental Subscale (CFSS‐DS) and the Modified Child Dental Anxiety Scale (faces) (MCDASf) were completed by children.ResultsThe mean age of the control group and the DGA group was 9.5 ± 1.7 and 8.8 ± 1.5 years old, respectively (P > 0.05). The time passed since DGA was experienced ranged between 1.2 and 6.9 years ago (mean: 4.2 ± 1.1 years). The mean CFSS‐DS and MCDASf scores for the DGA group (34.3 and 20.4, respectively) were significantly greater when compared to the control group (23.6 and 12.7, respectively) (P < 0.001).ConclusionChildren who experienced DGA are a high‐risk group for DFA several years after the procedure. The DGA status could be used for identifying anxious children to promote better behaviour management.
Induction of migration of periodontal ligament cells by selective regulation of integrin subunits
Authors: Kawamura Mari , Yamamoto Tadashi , Yamashiro Keisuke , Kochi Shinsuke , Yoshihara‐Hirata Chiaki , Ideguchi Hidetaka , Aoyagi Hiroaki , Omori Kazuhiro , Takashiba Shogo 
Published: December 2018

AbstractThe recruitment of tissue‐resident stem cells is important for wound regeneration. Periodontal ligament cells (PDL cells) are heterogeneous cell populations with stemness features that migrate into wound sites to regenerate periodontal fibres and neighbouring hard tissues. Cell migration is regulated by the local microenvironment, coordinated by growth factors and the extracellular matrix (ECM). Integrin‐mediated cell adhesion to the ECM provides essential signals for migration. We hypothesized that PDL cell migration could be enhanced by selective expression of integrins. The migration of primary cultured PDL cells was induced by platelet‐derived growth factor‐BB (PDGF‐BB). The effects of blocking specific integrins on migration and ECM adhesion were investigated based on the integrin expression profiles observed during migration. Up‐regulation of integrins α3, α5, and fibronectin was identified at distinct localizations in migrating PDL cells. Treatment with anti‐integrin α5 antibodies inhibited PDL cell migration. Treatment with anti‐integrin α3, α3‐blocking peptide, and α3 siRNA significantly enhanced cell migration, comparable to treatment with PDGF‐BB. Furthermore, integrin α3 inhibition preferentially enhanced adhesion to fibronectin via integrin α5. These findings indicate that PDL cell migration is reciprocally regulated by integrin α3‐mediated inhibition and α5‐mediated promotion. Thus, targeting integrin expression is a possible therapeutic strategy for periodontal regeneration.
Adverse events identified by the global trigger tool at a university hospital: A retrospective medical record review
Authors: Hu Qiaozhi , Wu Bin , Zhan Mei , Jia Weiguo , Huang Yimei , Xu Ting 
Published: December 2018

AbstractObjectivesThe purpose of this study was to describe the level, preventability and categories of adverse events (AEs) in Chinese geriatric patients identified by medical record review using the Global Trigger Tool. The applicability of the GTT was also assessed to explore possible modifications for trigger tools.MethodsThe study was conducted at a 4300‐bed tertiary teaching hospital. Twenty randomly‐selected medical records for patients over 60 were reviewed every 2 weeks from January 1 2015 to December 31st, 2015. We studied 480 medical records in total. Two trained specialists reviewed the presence of AEs using 43 triggers, and a physician reviewed and validated the findings. The outcome measures included the number of AEs per 1000 patient days, AEs per 100 admissions, the percentage of entries with at least 1 AE and AE categorisation. Also, we carried out a descriptive analysis of the suspected factors of AEs, such as age, gender, length of stay, surgery.ResultsA total of 610 AEs were detected in the 480 medical records reviewed, corresponding to 127 injuries per 100 admissions. The number of AEs per 1000 patient days was 22.43. AEs occurred at least once in 329 (68.54%) patients. The rate of care harms ranked highest of all AEs, followed by the rate of medication harms and surgical harms. Patients with a more extended hospital stay or surgery was more likely to experience AEs. However, there was a negative correlation between age and the rate of AEs.ConclusionThe Global Trigger Tool was a useful method for detecting the characteristics of AEs in geriatric patients in a Chinese tertiary teaching hospital. To improve patients’ safety, this tool should be incorporated into routine screening systems.