bluuebunny/crossref_metadata_2025_split huggingface dataset:
Utilization and Real-world Effectiveness of Tranexamic Use in Shoulder Arthroplasty: A Population-based Study
Authors: Anthony Shawn G. , Patterson Diana C. , Cagle Paul J. , Poeran Jashvant , Zubizarreta Nicole , Mazumdar Madhu , Galatz Leesa M. 
Published: April 2019

Introduction:
Tranexamic acid (TXA) is increasingly used to reduce blood loss in lower extremity arthroplasty, but limited data exist for its effectiveness in patients undergoing shoulder arthroplasty. We aimed to use national data to assess the frequency of use and effectiveness of TXA in patients undergoing shoulder arthroplasty.

Methods:
Using national claims data from patients undergoing shoulder arthroplasty (Premier Healthcare; 2010 to 2016; n = 82,512; 429 hospitals), we categorized patients according to whether they received perioperative TXA. Multilevel multivariable regression models measured associations between TXA and blood transfusion risk, combined complications (including thromboembolic events, acute renal failure, cerebral infarction, and acute myocardial infarction), and length and cost of hospitalization. Odds ratios (ORs) and 95% confidence intervals (CIs) are reported.

Results:
Overall, TXA was used in 12.8% (n = 10,582) of patients with a strong increasing trend. After adjustment for relevant covariates, TXA use (compared with no TXA use) was associated with a 36% decrease in transfusion risk (OR, 0.64; 95% CI, 0.52 to 0.77; P < 0.05) and a 35% decreased risk for combined complications (OR, 0.65; 95% CI, 0.50 to 0.83; P < 0.05). Moreover, TXA use was associated with 6.2% shorter hospital stay (95% CI, −8.0% to −4.4%; P < 0.05), whereas no difference was observed with the cost of hospitalization.

Conclusion:
In this first large-scale study assessing TXA use and effectiveness in patients undergoing shoulder arthroplasty, we found that although TXA utilization is still low, it is associated with a marked decrease in transfusion risk with no increases in complication risk. Effects on the length and cost of hospitalization appeared minor. Future studies should assess whether higher volumes of TXA utilization would translate into more gains on the length and cost of hospitalization.

Level of Evidence:
Level III
Variables tangibles e intangibles sobre productos y servicios: la creacción de itness application ‘punnett square’ (faps)
Authors: Addolorato S. 
Published: April 2019

La industria fitness y salud (H&F) siempre marcó más las variables tangibles de los productos antes de las intangibles. Hoy en día, en los modelos de negocios que funcionan, se ha demostrado como estas resultan increíblemente útiles. La aplicabilidad y usabilidad de recursos fitness (productos, servicios o soluciones mixtas) se planean sobre el innovador enfoque que define estas calidades más escondidas. Esta revisión de la literatura académica tiene el reto de evidenciar este ‘lado B’. La introducción de la herramienta nombrada Fitness Applications ‘Punnett Square’ (FAPS) ayudará a entender de forma mejor los recursos del sector fitness que siguen en continuo desarrollo. También, resultará aplicable a todos los profesionales del sector que utilizan equipos (físicos o menos) en su día a día en instalaciones deportivas. Bien para todo lo que ya está en posesión para aumentar los niveles de valoracción, tanto como para todas las elicciones frente a acciones futuras.
Health and fitness (H&F) industry has always highlighted product’s tangible variables over untouchable ones. Nowadays conspicuous market models are proving that these facets are increasingly required by international societies and contexts and are demonstrated to be incredibly useful. The applicability and usability of fitness resources (products, services or mixed solutions) depends upon a genuinely innovative approach to the definition of those hidden intangible variables. This literature analysis underline that also academic contributions focus more attention on ‘touchable’ variables, but it’s now the time for the ‘B side’. The introduced Fitness Applications ‘Punnett Square’ (FAPS) tool helps to better understand the ever-growing world of fitness industry resources. It is also direct applicable to all those sector professionals who operate in their daily-life facility routine, with the final goal to increase levels of assessment of H&F product and service knowledge, for what already own and for emergent choices or purchasing actions.
El efecto de la ansiedad en el tiempo de reacción de los estudiantes de Educación Física de la Universidad de Tabriz, Irán
Authors: Delir A. , Garehbagh M. 
Published: April 2019

El objetivo del presente estudio es investigar el efecto de la ansiedad y el tiempo de reacción en estudiantes de la Universidad de Tabriz. Participaron 48 estudiantes (24 mujeres y 24 hombres) de Educación Física de la Universidad de Tabriz. Los estudiantes fueron evaluados mediante el cuestionario de escala de Spielberger y la prueba del tiempo de reacción para determinar el nivel de ansiedad. El muestreo se realizó de manera aleatoria en estudiantes de Educación Física de la Universidad de Tabriz, con una edad de 22 ± 3 años. Después de comprobar la normalidad de los datos, a través del análisis de varianza, se analizaron dos factores (ansiedad y tiempo de reacción) en cada grupo para cada una de las variables individualmente. Los resultados indicaron que hubo una relación negativa entre la ansiedad-estado y el tiempo de reacción de las manos (r = 0.112, p = 0.398) y entre la ansiedad-rasgo y el tiempo de reacción simple de los pies (r = 0.209, p = 0.154). Además, hubo una relación positiva entre la ansiedad-estado y el tiempo de reacción simple de los pies (p = 0.0625, r = -0.072) y entre la ansiedad-rasgo y el tiempo de reacción de las manos (p = 0.874, r = -0.024). Los resultados de este estudio respaldan la hipótesis de la U invertida.
The objective of the present study is to investigate the effect of anxiety and reaction time in students of the University of Tabriz. 24 female and 24 male physical education students of Tabriz University responded to the Spielberger Scale Questionnaire and the Reaction Time Test to determine the level of anxiety. Sampling was conducted randomly from physical education students of Tabriz University with the age 22 ± 3. After ensuring that the data were normal, through the variance analysis, two in-group factors of anxiety and reaction time were analyzed for each of the variables individually. The results indicated that there was a negative relationship between state anxiety and choice reaction time of hands (r = 0.112, p = 0.398) and between trait anxiety and simple reaction time of feet (r = 0.209, p = 0.154). In addition, there was a positive relationship between state anxiety and simple reaction time of feet (p = 0.0625, r = -0.072) and between trait anxiety and choice reaction time of hands (p = 0.874, r = -0.024). The results of this study support the Inverted U hypothesis.
Enhancement of carbon monoxide concentration in atmosphere due to large scale forest fire of Uttarakhand
Authors: Thakur Jaya , Thever Prajesh , Gharai Biswadip , Sesha Sai MVR , Pamaraju VNRao 
Published: April 2019

The richly forested Indian state of Uttarakhand experienced widespread forest fires in April to May 2016. The current study examines dispersion of carbon monoxide (CO) from the source regions of forest fire to distant places, using the Lagrangian particle dispersion model, FLEXPART. Atmospheric Infrared Sounder (AIRS) observations revealed that CO columnar concentrations had increased by almost 28 percentage during 24 April to 02 May 2016 with respect to the previous non-burning period of April 2016 at Uttarakhand. It is also seen that there is considerable enhancement of 45 percentage in average columnar concentration of CO during the burning period, compared to that in the previous 5 years as observed by AIRS. In the present study, concentrations of CO at different pressure levels and columnar CO over Uttarakhand during the forest fire event have been simulated using FLEXPART. The area averaged profile of model derived CO has been compared with the profile from AIRS onboard Aqua. Comparison between model derived columnar CO and satellite observations shows good agreement with coefficient of correlation (r) approximately 0.91 over the burnt areas. Further analysis using FLEXPART reveals that the transport of pollutants is towards north-eastern and eastern regions from the locations of forest fire events. Model derived vertical distribution of CO over Tibet, which is situated at the north-east of Uttarakhand, shows significant increase of CO concentration at higher altitudes around 3 km from the mean sea level during the fire event. FLEXPART results show that the emissions from the Uttarakhand fires were transported to Tibet during the study period.
In vitro and in vivo Investigations of a Sudanese Honey in the Management of Dermatological Fungal Infections
Authors: Suliman Rasha Saad , Ali Heyam Saad , Husayn Abd Araheem , M. A. Elhaj Babiker , Suliman Rania 
Published: April 2019

Superficial fungal infections represented 17% of skin diseases in patients attending the outpatient clinic of Khartoum Hospital of Skin and Venereal Diseases.
The treatment of these infections usually involves the use of systemic drugs and/or topical well-tried preparations. All of the drugs carry a potential of adverse reactions, besides their relatively high cost. Honey, which is a natural product of the honeybee, is believed to be active against fungi. In this study, honey was used as topical treatment for six different clinical syndromes of superficial fungal infections.
The study, which was carried out at the outpatient clinic of Khartoum Hospital of Skin and Venereal Diseases, included 360 patients (210 males and 150 females) with skin, hair and nail infections. Patients, diagnosed by clinical examination and direct microscopy (KOH), were given honey to be applied on their lesions twice daily. Follow-up was made weekly by both clinical and laboratory evaluations. A complementary follow-up visit after 4 weeks of completion of treatment was needed in order to trace any clinical or mycological changes. Clinical and mycological cure showed some difference. Two hundred and sixty patients (72.4%) showed clinical cure associated with hyphal clearance on direct microscopy. Spores were not affected by honey, a direct cause of high relapse rate (42.3%). It is concluded that honey had a therapeutic effect on skin and scalp fungal infections but nail infection were not affected.
C−O coupling of Malonyl Peroxides with Enol Ethers via [5+2] Cycloaddition: Non‐Rubottom Oxidation
Authors: Vil' Vera A. , Gorlov Evgenii S. , Bityukov Oleg V. , Barsegyan Yana A. , Romanova Yulia E. , Merkulova Valentina M. , Terent'ev Alexander O. 
Published: April 2019

AbstractMalonyl peroxides act both as oxidants and reagents for C−O coupling in reactions with methyl and silyl enol ethers. In the proposed conditions, the oxidative C−O coupling of malonyl peroxides with enol ethers selectively proceeds, bypassing the traditional Rubottom hydroxylation of enol ethers by peroxides. It was observed that the oxidative [5+2] cycloaddition of malonyl peroxides and enol ethers is the key stage of the discovered process. Oxidative C−O coupling of silyl enol ethers leads to the formation of α‐acyloxyketones with a free carboxylic acid group. A specially developed preparative one‐pot procedure transforms ketones via silyl enol ethers formation and the following coupling into α‐acyloxyketones with yields 35–88%. The acid‐catalyzed coupling with methyl enol ethers gives remarkable products while retaining the easily oxidizable enol fragment. Furthermore, these molecules contain a free carboxylic acid group, thus these nontrivial products contain two usually incompatible acid and enol ether groups.magnified image
A Dual‐Ion Organic Symmetric Battery Constructed from Phenazine‐Based Artificial Bipolar Molecules
Authors: Dai Gaole , He Yan , Niu Zhihui , He Ping , Zhang Changkun , Zhao Yu , Zhang Xiaohong , Zhou Haoshen 
Published: April 2019

AbstractSymmetric batteries received an increasing research interest in the past few years because of their simplified fabrication process and reduced manufacturing cost. In this study, we propose the first dual‐ion organic symmetric cell based on a molecular anion of 4,4′‐(phenazine‐5,10‐diyl)dibenzoate. The alkali salt of 4,4′‐(phenazine‐5,10‐diyl)dibenzoate allows a facile transport of cations and large anions, and remains stable in both oxidized and reduced states. The large potential difference between phenazine and benzoate results in a high cell voltage of 2.5 V and an energy density of 127 Wh kg−1 at a current rate of 1 C. The introduction of bipolar organic materials may further consolidate the development of symmetric batteries that are fabricated from abundant elements and environmentally friendly materials.
Synthesis and Properties of Azide‐Functionalized Ionic Liquids as Attractive Hypergolic Fuels
Authors: Wang Zhenyuan , Pan Guangxing , Wang Binshen , Zhang Ling , Zhao Weiwei , Ma Xing , Zhang Jichuan , Zhang Jiaheng 
Published: April 2019

AbstractHypergolic ionic liquids (ILs) have shown a great promise as viable replacements for toxic and volatile hydrazine derivatives used as propellant fuels, and hence, have attracted increasing interest over the last decade. To take advantage of the reactivity and high energy density of the azido group, a family of low‐cost and easily prepared azide‐functionalized cation‐based ILs, including fuel‐rich anions, such as nitrate, dicyanamide, and nitrocyanamide anions, were synthesized and characterized. All the dicyanamide‐ and nitrocyanamide‐based ILs exhibited spontaneous combustion upon contact with 100 % HNO3. The densities of these hypergolic ILs varied in the range 1.11–1.29 g cm−3, and the density‐specific impulse, predicted based on Gaussian 09 calculations, was between 289.9 and 344.9 s g cm−3. The values of these two key physical properties are much higher than those of unsymmetrical dimethylhydrazine (UDMH). Among the studied compounds, compound IL‐3b, that is, 1‐(2‐azidoethyl)‐1‐methylpyrrolidin‐1‐ium dicyanamide, shows excellent integrated properties including the lowest viscosity (30.9 M Pa s), wide liquid operating range (−70 to 205 °C), shortest ignition‐delay time (7 ms) with 100 % HNO3, and superior density specific impulse (302.5 s g cm−3), suggesting promising applications with potential as bipropellant formulations.
Endovascular stenting for idiopathic intracranial hypertension with venous sinus stenosis
Authors: Liu Xinfeng , Di Hai , Wang Jun , Cao Xiangyu , Du Zhihua , Zhang Rongju , Yu Shengyuan , Li Baomin 
Published: April 2019

AbstractObjectivesIdiopathic intracranial hypertension (IIH) is characterized by elevated intracranial pressure of unknown etiology and venous sinus stenting may be an optional treatment. We aimed to evaluate the effects of venous sinus stenting on visual function, intracranial pressure, and trans‐stenotic pressure gradient of the patients with IIH and to determine effects of baseline BMI or weight changes on subjective vision outcome and intracranial pressure.MethodsFrom July 2009 to Aug 2016, 88 eligible patients with IIH and venous sinus stenosis who underwent stenting were retrospectively studied.ResultsIn this study, 67 women and 21 men were included with an average age of 39.01 (18–60) years. The average BMI was 26.75 kg/m2. Here, 66 (75.9%) patients had papilledema, 39 had impaired vision before stenting; 57 patients were followed‐up, 48 (84.2%) showed significant subjective improvement or recovery in visual acuity, 4 (7.0%) patients reported no significant change in visual functions, and 5 (8.8%) suffered permanent vision loss. The cerebrospinal fluid opening pressure and trans‐stenotic pressure gradient were significantly decreased postoperatively. Baseline BMI was associated with pre‐and postoperative trans‐stenotic pressure gradients, as well as changes in cerebrospinal fluid opening pressure. However, baseline BMI and body weight changes during follow‐up were not necessarily associated with subjective visual outcomes after stenting. Stenting efficacy was limited in patients with severe preoperative optic symptoms.ConclusionsVenous sinus stenting represented an effective treatment for resolving visual dysfunction and intracranial pressure associated with venous sinus stenosis. BMI seemed to be associated with intracranial pressure but not subjective visual outcomes after stenting.
Multistage continuous countercurrent diafiltration for formulation of monoclonal antibodies
Authors: Jabra Mario G. , Yehl Christopher J. , Zydney Andrew L. 
Published: April 2019

AbstractThere is growing interest in the development of fully integrated and continuous biomanufacturing processes for the production of monoclonal antibody products. A recent study has demonstrated the feasibility of using a two‐stage countercurrent diafiltration (DF) process for continuous product formulation, but this system did not provide sufficient levels of buffer exchange for most applications. The objective of this study was to design and test a three‐stage countercurrent DF system that could achieve at least 99.9% buffer exchange over 24 hr of continuous operation. Experimental data were obtained using concentrated solutions of human immunoglobulin G as a model protein, with the extent of vitamin B12 removal used to track the extent of DF. Pall Cadence™ inline concentrators with Delta 30 kD regenerated cellulose membranes were used in the three stages to achieve high conversion in a single pass. The three‐stage system showed stable operation with >99.9% vitamin B12 removal and a minimal increase in pressure over the full 24 hr. Modules were effectively cleaned using sodium hydroxide, with nearly complete recovery of water permeability. A simple economic analysis was presented that accounts for the trade‐offs between quantity of buffer used and membrane costs for this type of countercurrent staged DF process. The results provide important insights to the design and operation of a continuous process for antibody formulation.
NEAT1 promotes myocardial ischemia‐reperfusion injury via activating the MAPK signaling pathway
Authors: Du Xian‐Jin , Wei Jie , Tian Dan , Yan Chen , Hu Peng , Wu Xu , Yang Wenbin , Hu Xiaorong 
Published: April 2019

AbstractMyocardial ischemia‐reperfusion (IR) injury is a common cardiovascular problem, which remains a major cause of death in the world. Emerging evidence has suggested that long noncoding RNAs are crucial players in myocardial injury. However, the functional involvement of nuclear enriched abundant transcript 1 (NEAT1) in myocardial IR injury remains poorly investigated. Our study focused on the mechanism of NEAT1 in myocardial IR injury. Here, we reported a crucial role for NEAT1 in exacerbating cardiac IR injury. NEAT1 was greatly increased in myocardial IR injury mice models. As exhibited knockdown of NEAT1 resulted in attenuated myocardial IR injury in vivo. In addition, we found that NEAT1 was dramatically induced by hypoxia/reoxygenation in H9c2 cells. Lactate dehydrogenase (LDH), malondialdehyde, reactive oxygen species levels, and endoplasmic reticulum stress‐regulated cardiomyocyte apoptosis were inhibited by the downregulation of NEAT1. Here, it was shown that knockdown of NEAT1 was able to repress tumor necrosis factor‐α, interleukin‐1β, and IL‐6 expression. The silence of NEAT1 protected against IR injury via decreasing troponin levels, cardiocytes apoptosis, creatine kinase, and lactate LDH release in vivo. Meanwhile, the mitogen‐activated protein kinase (MAPK) signaling was involved in NEAT1‐mediated myocardial IR injury. In summary, our data indicated that NEAT1 contributed to myocardial IR injury via activating the MAPK pathway.
Activation of the STAT3/microRNA‐21 pathway participates in angiotensin II‐induced angiogenesis
Authors: Chen Li‐Yuan , Wang Xue , Qu Xiao‐Long , Pan Li‐Na , Wang Ze‐Yang , Lu Yong‐Hui , Hu Hou‐Yuan 
Published: April 2019

AbstractAngiotensin II (AngII) facilitates angiogenesis that is associated with the continuous progression of atherosclerotic plaques, but the underlying mechanisms are still not fully understood. Several microRNAs (miRNAs) have been shown to promote angiogenesis; however, whether miRNAs play a crucial role in AngII‐induced angiogenesis remains unclear. This study evaluated the functional involvement of miRNA‐21 (miR‐21) in the AngII‐mediated proangiogenic response in human microvascular endothelial cells (HMECs). We found that AngII exerted a proangiogenic role, indicated by the promotion of proliferation, migration, and tube formation in HMECs. Next, miR‐21 was found to be upregulated in AngII‐treated HMECs, and its specific inhibitor potently blocked the proangiogenic effects of AngII. Subsequently, we focused on the constitutive activation of STAT3 in the AngII‐mediated proangiogenic process. Bioinformatic analysis indicated that STAT3 acted as a transcription factor initiating miR‐21 expression, which was verified by ChIP‐PCR. A reporter assay further identified three functional binding sites of STAT3 in the miR‐21 promoter region. Moreover, phosphatase and tensin homolog (PTEN) was recognized as a target of miR‐21, and STAT3 inhibition restored AngII‐induced reduction in PTEN. Similarly, the STAT3/miR‐21 axis was shown to mediate AngII‐provoked angiogenesis in vivo, which was demonstrated by using the appropriate inhibitors. Our data suggest that AngII was involved in proangiogenic responses through miR‐21 upregulation and reduced PTEN expression, which was, at least in part, linked to STAT3 signaling. The present study provides novel insights into AngII‐induced angiogenesis and suggests potential treatment strategies for attenuating the progression of atherosclerotic lesions and preventing atherosclerosis complications.
The role of pretreatment prognostic nutritional index in esophageal cancer: A meta‐analysis
Authors: Xue Yibo , Zhou Xiang , Xue Lei , Zhou Ruhua , Luo Jinhua 
Published: April 2019

AbstractClinicopathological characteristics and prognosis of esophageal cancer (EC) patients with decreased prognostic nutritional index (PNI) have not been well investigated. So, we conducted this meta‐analysis. We performed comprehensive research in PubMed, Embase, and Cochrane databases. The effect size was hazard ratio (HR) with 95% confidence interval (CI) for overall survival (OS) and cancer‐specific survival (CSS). The pooled odds ratio (OR) with 95% CI were used to assess the association between PNI and clinicopathological features. A total of 3,425 EC patients were included in the present meta‐analysis. Male patients, advanced age, higher tumor stage, and lymph node metastases were associated with reduced PNI level (OR = 1.40, 95% CI: 1.10‐1.79; OR = 1.35, 95% CI: 1.10‐1.66; OR = 2.37, 95% CI: 1.91‐2.94; OR = 1.63, 95% CI: 1.04‐2.56). And, the EC patients with decreased PNI held a worse OS and CSS compared with those who carried a higher PNI (HR = 1.29, 95% CI: 1.10‐1.50; HR = 2.53, 95% CI: 1.15‐5.57). This meta‐analysis demonstrated PNI level was associated with tumor stage and lymph nodes metastases and was an independent prognostic factor in EC.