bluuebunny/crossref_metadata_2025_split huggingface dataset:
How do patients from South Asian backgrounds experience life on haemodialysis in the UK? A multicentre qualitative study
Authors: Sharma Shivani , King Madeline , Mooney Roisin , Davenport Andrew , Day Clara , Duncan Neill , Modi Kirit , Da Silva-Gane Maria , Wellsted David , Farrington Ken 
Published: May 2019

ObjectivesEnd-stage kidney disease disproportionately affects people of South Asian origin. This study aimed to uncover the lived experiences of this group of patients on centre-based haemodialysis (HD), the most prevalent dialysis modality.DesignThe study utilised a qualitative focus group methodology. Seven focus groups were conducted across four NHS Trusts in the UK including three in Gujarati and two each in Punjabi and Urdu. This provided an inclusive opportunity for South Asian patients to contribute in their language of origin. A total of 24 patients participated. Focus groups were facilitated by bilingual project workers and data were forward translated and analysed using thematic analysis.ResultsFour themes were identified. This included (1) ‘treatment imposition’, which comprised of the restrictive nature of HD, the effects of treatment and the feeling of being trapped in an endless process. (2) The ‘patient–clinician relationship’ centred around the impact of a perceived lack of staff time, and inadequacies in the quality of interactions. (3) ‘Coping strategies’ highlighted the role of cognitive reappraisal, living in the moment and family support networks in facilitating adjustment. (4) ‘Pursuit of transplantation’ included equating this form of treatment with restoring normality, alongside cultural factors limiting hopefulness for receiving an organ.ConclusionsIn general, the experiences of South Asian patients receiving HD were not unique to this ethnic group. We did find distinct issues in relation to interactions with healthcare professionals, views on access to transplantation and the importance of family support networks. The study provides useful insights which may help enhance culturally tailored renal care.
Prevalence and impact of clinical violence towards nursing students in Hong Kong: a cross-sectional study
Authors: Cheung Kin , Ching Shirley SY , Cheng Samuel Hung Nam , Ho Simone Sin Man 
Published: May 2019

ObjectivesStudies of violence towards nursing students (NSs) have been scattered mainly in the West and Middle East, but to date there have been no studies in Eastern countries. Differences in nursing education systems and cultures might have contributed to variations in incidences of clinical violence. The purpose of this study was to investigate the prevalence, associated factors and impact of clinical violence to NSs.MethodsThis was a cross-sectional survey study. Convenience sampling was used to recruit university NSs from March to June 2012 in classroom settings in Hong Kong. A valid and reliable questionnaire was used to collect the data. 1297 questionnaires were distributed and 1017 NSs completed questionnaires, with a response rate of 78.41%.ResultsOf the 1017 NSs, 37.3% (n=379) reported having experienced clinical violence during their nursing studies. The prevalence of verbal abuse (30.6%) was significantly greater than that of physical violence (16.5%). The perpetrators of verbal abuse were predominantly patients (66.8%), hospital staff (29.7%), university supervisors (13.4%) and patients’ relatives (13.2%). Patients (91.0%) were the greatest source of physically violent assaults. Compared with those who had experienced physical violence, the NSs who had experienced verbal abuse were more likely not to take action, and not to stop or report the incident, but were also more likely to tell their friends/families. Although the negative effects on emotions, clinical performance and the extent to which they were disturbed by the violence were significantly greater for verbal abuse than that for physical violence, their intention to leave the nursing profession after experiencing either verbal or physical violence was significantly higher after than before the experience (p<0.001).ConclusionsOur results found a moderately high prevalence of clinical violence among NSs. Provision and/or reinforcement of appropriate training about clinical violence in the nursing curricula is necessary.
Effectiveness of antitussives, anticholinergics or honey versus usual care in adults with uncomplicated acute bronchitis: a study protocol of an open randomised clinical trial in primary care
Authors: Cots Josep M , Moragas Ana , García-Sangenís Ana , Morros Rosa , Gomez-Lumbreras Ainhoa , Ouchi Dan , Monfà Ramon , Pera Helena , Pujol Jesus , Bayona Carolina , de la Poza-Abad Mariam , Llor Carl 
Published: May 2019

IntroductionDespite the frequent use of therapies in acute bronchitis, the evidence of their benefit is lacking, since only a few clinical trials have been published, with low sample sizes, poor methodological quality and mainly in children. The objective of this study is to compare the effectiveness of three symptomatic therapies (dextromethorphan, ipratropium or honey) associated with usual care and the usual care in adults with acute bronchitis.Methods and analysisThis will be a multicentre, pragmatic, parallel group, open randomised trial. Patients aged 18 or over with uncomplicated acute bronchitis, with cough for less than 3 weeks as the main symptom, scoring ≥4 in either daytime or nocturnal cough on a 7-point Likert scale, will be randomised to one of the following four groups: usual care, dextromethorphan 30 mg three times a day, ipratropium bromide inhaler 20 µg two puffs three times a day or honey 30 mg (a spoonful) three times a day, all taken for up to 14 days. The exclusion criteria will be pneumonia, criteria for hospital admission, pregnancy or lactation, concomitant pulmonary disease, associated significant comorbidity, allergy, intolerance or contraindication to any of the study drugs or admitted to a long-term residence. Sample: 668 patients. The primary outcome will be the number of days with moderate-to-severe cough. All patients will be given a paper-based symptom diary to be self-administered. A second visit will be scheduled at day 2 or 3 for assessing evolution, with two more visits at days 15 and 29 for clinical assessment, evaluation of adverse effects, re-attendance and complications. Patients still with symptoms at day 29 will be called 6 weeks after the baseline visit.Ethics and disseminationThe study has been approved by the Ethical Board of IDIAP Jordi Gol (reference number: AC18/002). The findings of this trial will be disseminated through research conferences and peer-review journals.Trial registration numberNCT03738917; Pre-results.
The effects of the size and structure on magnetic behavior of core/shell nanoparticles
Authors: Le Long V. , Le Vinh V. , Ho Quy Q. 
Published: May 2019

Molecular dynamics (MD) simulations have been employed to simulate the structure of Ni nanoparticles (NPs). These NPs consist of 500, 1372, 2916 and 5324 atoms. Various structures of these NPs, consisting of faced-centered cubic (fcc), hexagonal closed packed (hcp), icosahedral (ico) and amorphous states, have been simulated by changing the cooling rate from 2000 to 300 K. The models of mixed core/shell spin (1, 3/2) have been set based on the NPs. Monte Carlo (MC) simulation has been applied to investigate the magnetic behavior and phase diagrams of the models. We have found that the structure of the models plays important role on the characteristic phase diagrams. The effects of the atomic number as well as the exchange coupling J[Formula: see text]/J[Formula: see text] (J[Formula: see text] — the shell coupling and J[Formula: see text] — the core coupling) on the thermal and magnetic behaviors of the models have been presented and discussed. The phase diagrams in k[Formula: see text]T/J[Formula: see text]−J[Formula: see text]/J[Formula: see text] plane also have been observed by changing the structure and the number atoms of the models.
A comparative study of finite frequency scattering rate from Allen, Mitrović–Fiorucci, Shulga–Dolgov–Maksimov, Sharapov–Carbotte and memory function formalisms
Authors: Bhalla Pankaj , Singh Navinder 
Published: May 2019

We report a comparative study of scattering rates which are calculated using different formalisms such as [P. B. Allen, Phys. Rev. B 3, 305 (1971); S. V. Shulga, D. V. Dolgov and E. G. Maksimov, Physica C 178, 266 (1991); B. Mitrović and M. A. Fiorucci, Phys. Rev. B 31, 2694 (1985); S. G. Sharapov and J. P. Carbotte, Phys. Rev. B 72, 134506 (2005)] and memory function formalism (MemF) [H. Mori, Prog. Theor. Phys. 33, 423 (1965)]. An advantage of this study is that it sheds light on the physical assumptions used in these formalisms. In this context, we consider a case of electron–phonon interaction and discuss frequency- and temperature-dependent behavior of scattering rates. Further, a comparative study of scattering rate proceeds for distinct phonon density of states (PDOS) and electron density of states (EDOS). From the detailed analysis, we observe that the MemF is the most general one and others are based on restrictive assumptions as discussed in this work.
Effect of acute high-phosphate intake on muscle metaboreflex activation and vascular function
Authors: Stephens Brandi Y. , Kaur Jasdeep , Vranish Jennifer R. , Barbosa Thales C. , Blankenship Jeanette K. , Smith Scott A. , Fadel Paul J. 
Published: May 2019

Increased consumption of inorganic phosphate (Pi), an abundant ingredient in processed foods, has been associated with elevated cardiovascular disease risk; however, studies investigating underlying mechanisms are limited. Recently, high dietary Pi was shown to exaggerate the pressor response to static muscle contraction in rodents in part because of overactivation of metabolically sensitive skeletal muscle afferents. Whether acute high Pi consumption affects muscle metaboreflex activation in humans remains unknown. Furthermore, although acute high Pi consumption has been shown to impair vascular function in young healthy men, equivocal results have been reported. Therefore, we hypothesized that acute high Pi consumption augments mean arterial pressure (MAP) responses during muscle metaboreflex activation, impairs endothelial function, and increases arterial stiffness in young healthy men. Subjects performed 35% maximal voluntary contraction static handgrip (HG), followed by postexercise ischemia (PEI) to isolate muscle metaboreflex activation. Resting flow-mediated dilation (FMD) and arterial stiffness were assessed. Measures were made before (pre) and 60 min after (post) subjects consumed either a high-phosphate drink (2,000 mg phosphorus and 1,520 mg sodium) or a sodium drink (1,520 mg sodium; control). MAP responses during HG (preΔ = +23 ± 3 mmHg; postΔ = +21 ± 2 mmHg; P = 0.101) and PEI (preΔ = +21 ± 4 mmHg; postΔ = +18 ± 3 mmHg; P = 0.184) were similar before and after Pi consumption. In contrast, FMD was significantly attenuated following Pi (pre = 5.1 ± 0.5%; post = 3.5 ± 0.5%; P = 0.010), whereas arterial stiffness remained unchanged. There were no changes in any measured variable after control drink consumption. In summary, although the muscle metaboreflex remains unaffected following acute high Pi consumption in young healthy men, endothelial function is impaired. NEW & NOTEWORTHY This study was the first to investigate the influence of acute high-phosphate consumption on the pressor response during isometric handgrip and isolated muscle metaboreflex activation during postexercise ischemia in young healthy humans. We demonstrated that a single high dose of phosphate (2,000 mg) did not augment blood pressure in response to exercise or isolated muscle metaboreflex activation, but endothelial function was blunted in young healthy men.
Phosphorylation of SOCS1 Inhibits the SOCS1–p53 Tumor Suppressor Axis
Authors: Saint-Germain Emmanuelle , Mignacca Lian , Huot Geneviève , Acevedo Mariana , Moineau-Vallée Karine , Calabrese Viviane , Bourdeau Véronique , Rowell Marie-Camille , Ilangumaran Subburaj , Lessard Frédéric , Ferbeyre Gerardo 
Published: May 2019

Abstract

Expression of the suppressor of cytokine signaling-1 (SOCS1) is inactivated in hematopoietic and solid cancers by promoter methylation, miRNA-mediated silencing, and mutations. Paradoxically, SOCS1 is also overexpressed in many human cancers. We report here that the ability of SOCS1 to interact with p53 and regulate cellular senescence depends on a structural motif that includes tyrosine (Y)80 in the SH2 domain of SOCS1. Mutations in this motif are found at low frequency in some human cancers, and substitution of Y80 by a phosphomimetic residue inhibits p53–SOCS1 interaction and its functional consequences, including stimulation of p53 transcriptional activity, growth arrest, and cellular senescence. Mass spectrometry confirmed SOCS1 Y80 phosphorylation in cells, and a new mAb was generated to detect its presence in tissues by IHC. A tyrosine kinase library screen identified the SRC family as Y80-SOCS1 kinases. SRC family kinase inhibitors potentiated the SOCS1–p53 pathway and reinforced SOCS1-induced senescence. Samples from human lymphomas that often overexpress SOCS1 also displayed SRC family kinase activation, constitutive phosphorylation of SOCS1 on Y80, and SOCS1 cytoplasmic localization. Collectively, these results reveal a mechanism that inactivates the SOCS1–p53 senescence pathway and suggest that inhibition of SRC family kinases as personalized treatment in patients with lymphomas may be successful.

Significance:
These findings show that SOCS1 phosphorylation by the SRC family inhibits its tumor-suppressive activity, indicating that patients with increased SOCS1 phosphorylation may benefit from SRC family kinase inhibitors.
Retinoblastoma Loss in Cancer: Casting a Wider Net
Authors: Choudhury Atish D. , Beltran Himisha 
Published: May 2019

Abstract
Capturing both genomic and nongenomic mechanisms of retinoblastoma gene dysfunction has potential to improve risk stratification and patient selection for biomarker-driven therapy. A 186-gene expression signature is capable of identifying Rb loss across cancer types, providing a new framework for assessing Rb dysfunction based on transcriptome data.
See related article by Chen et al., p. 4290
Facing the Refugee Challenge in Europe: A Litmus Test for the European Union
Authors: Rizcallah Cecilia 
Published: May 2019

Abstract
According to mainstream discourse, the EU is facing a ‘refugee crisis’ due to a mass influx of asylum seekers, which is putting the Common European Asylum System (CEAS) under pressure. Although this article acknowledges that the CEAS is currently under pressure, it aims to take a different view from the assumption that the—admittedly significant—arrival of asylum seekers constitutes in itself a problem for the EU. It suggests that the problems encountered by the CEAS are rather symptomatic of a deeper gridlock resulting from this system’s lack of compliance with two main EU’s fundamental values, the respect of which constitutes the ‘fundamental premise’ of EU integration, namely solidarity and human rights. From both an historical and a legal perspective, the EU is indeed founded on a set of values comprising the respect of human rights and solidarity. The treaties further require their respect internally (i.e. Articles 2 and 6 TEU), but also vis-à-vis the rest of the world (i.e. Articles 3(5) and 21 TEU). However, the current responses to the arrival of asylum-seekers are, in several respects, in contradiction with these founding values. On the one hand, the internal management of the influx of refugees reveals a lack of solidarity and results in breaches of asylum-seekers’ fundamental rights. On the other, the EU’s asylum policy does not meet the requirement according to which the Union shall, in its relations with the wider world, uphold and promote these values. These observations lead us to believe that facing the refugee challenge constitutes, from a normative perspective at least, a litmus test for the EU at large. Indeed, the EU’s difficulties in dealing with the arrival of the asylum seekers—which have already been the subject of extensive research—appear to be the evidence of an identity crisis. The way the EU, hand in hand with its Member States, responds to this challenge thus amounts to a ‘decisively indicative test’ for its normative foundations that are a prerequisite for the viability of the entire undertaking, and, notably, of the principle of mutual trust.
Meaningful occupations of young adults with muscular dystrophy and other neuromuscular disorders
Authors: Lindsay Sally , Cagliostro Elaine , McAdam Laura 
Published: May 2019

Background. Youth with Duchenne muscular dystrophy (DMD) and other neuromuscular disorders are living well into adulthood and often need help engaging in meaningful occupations. Purpose. Our purpose was to explore enablers and barriers to engaging in meaningful occupations, from the perspectives of youth, parents, and practitioners. Method. This qualitative study involved 26 participants (11 parents, eight youth ages 19 to 28 [mean = 22.3 years], seven practitioners). Data were obtained from semistructured interviews and analyzed using an interpretive descriptive approach. Findings. Youth with DMD and neuromuscular disorders engage in meaningful occupations in a variety of ways. Occupational enablers were supports and accommodations and self-care skills and coping strategies, while occupational barriers involved societal expectations of a normative adulthood, discrimination and inaccessible environments, lack of supports and resources, medical challenges, fatigue, lack of motivation, and social isolation and depression. Implications. Practitioners should work to uncover what youth consider important and connect them to appropriate resources so they can engage in meaningful occupations.
Epidemiological study on hand, foot and mouth disease in Tongzhou District, Beijing, 2013–2017
Authors: Liu Xiao-Feng , Sun Xiu-Mei , Sun Xiao-Wei , Yang Yu-Qing , Huang Cong-Hui , Wen Han 
Published: May 2019

Objective To study the epidemiological characteristics of hand, foot and mouth disease (HFMD) in Tongzhou District, Beijing between 2013 and 2017. Methods Data on HFMD infections from 1 January 2013 to 31 December 2017 were collected from the Notifiable Infectious Diseases Reporting Information System and analysed. Serotyping of enteroviruses from samples from patients with HFMD was undertaken using reverse transcription–polymerase chain reaction. Results A total of 15 341 patients with HFMD were reported and 32 patients (0.2%) were classified as having severe HFMD. The annual mean incidence rate of HFMD was 219.3/100 000 of the general population. The incidence and case-severity rates of HFMD generally decreased between 2013 and 2017. In the floating migrant population, the incidence and cases-severity rates of HFMD were significantly higher than in the local population. The peak incidence and severity-case rates were at 2 years of age and > 90% of patients were ≤5 years. Enterovirus A71 and Coxsackievirus A16 were the predominant pathogens in 2013–2017. Conclusions During the 5-year period 2013–2017, the incidence rate and case-severity rate of HFMD generally decreased in Tongzhou District, Beijing. The floating migrant population and children ≤5 years of age were at the highest risk of HFMD.
Efficacy and safety of tofacitinib for the treatment of chronic plaque psoriasis: a systematic review and meta-analysis
Authors: Tian Fangyuan , Chen Zhaoyan , Xu Ting 
Published: May 2019

Background Tofacitinib is an oral Janus kinase (JAK) inhibitor that targets JAK1 and JAK3, and thus regulates immune response. Therefore, tofacitinib is used to treat immune-mediated inflammatory diseases such as chronic plaque psoriasis. The objective of this study was to systematically assess the efficacy and safety of tofacitinib in treating chronic plaque psoriasis. Objective To systematically review the efficacy and safety of tofacitinib in the treatment of chronic plaque psoriasis, we performed a meta-analysis to evaluate the efficacy and safety of tofacitinib in patients with chronic plaque psoriasis. Methods Databases including PubMed, Embase, and The Cochrane Library were searched for randomized controlled trials about the efficacy and safety of tofacitinib in treating chronic plaque psoriasis from inception to August 2017 (PROSPERO Code No: CRD42017076587). Results Six articles (seven randomized controlled trial studies) involving 3743 patients were included. The meta-analysis results showed that for efficacy, tofacitinib (5 mg or 10 mg) compared with placebo can significantly improve the Physician’s Global Assessment response, PASI75, and PASI90 after treatment. For safety, the incidence of adverse reactions was statistically significantly higher for tofacitinib compared with placebo. Conclusion Treatment of chronic plaque psoriasis with tofacitinib is effective, but there may be more adverse reactions.
Expression levels of cathepsin L and cystatin C in a hyperglycemic environment were associated with aortic aneurysm development in a mouse model
Authors: Liu Yang , Jiao Yang , He Yuxiang , Ding Xiangjiu , Su Qingbo , Zhao Yan , Jiang Jianjun 
Published: May 2019

Objectives Diabetes mellitus (DM) attenuates the development of aortic aneurysms (AA). This study investigated the expression of cathepsin L and cystatin C in a hyperglycemic environment, and the influence of these proteins on AA development. Methods Mice were divided into AA and DM+AA groups ( n=30 per group). DM was induced by injection of streptozotocin; AA was induced by injection of angiotensin II. Doppler examination was used to measure aortic diameter, and Weigert’s elastic stain was used to detect elastin degradation. Cathepsin L and cystatin C in aortic tissue were examined by western blotting, immunohistochemistry, and polymerase chain reaction. Results Aortic diameter in the DM+AA group was less than that in the AA group, and elastin fragmentation grade of the aortic wall was reduced in the DM+AA group. More cathepsin L-positive cells were observed in the AA group than in the DM+AA group; conversely, more cystatin C-positive cells were observed in the DM+AA group than in the AA group. Both protein and mRNA levels of cathepsin L and cystatin C showed similar trends to those observed in immunohistochemistry. Conclusions Expression levels of cathepsin L and cystatin C in a hyperglycemic environment were associated with AA development in a mouse model.