bluuebunny/crossref_metadata_2025_split huggingface dataset:
Oxidative Stress Parameters after Abdominal Hysterectomy and Their Relationships with Quality of Recovery
Authors: Jovanovic Danijela , Milovanovic Dragan R. , Jeremic Nevena , Nikolic Tamara , Stojic Isidora , Jakovljevic Vladimir , Vukovic Natalija 
Published: July 2018

Abstract
Study aimed to investigate relationship between oxidative stress markers and postoperative recovery in woman after abdominal hysterectomy, as well as to test the hypothesis that different analgesics differently influence redox status.
The quality of recovery was evaluated with a QoR-40 questionnaire in fifty-one patients who underwent abdominal hysterectomy, preoperatively and on the 1st, 2nd, 3rd postoperative days (POD1,2,3). Blood samples were collected at baseline (T0), 3 (T1), 24 (T2), 48 (T3) and 72 (T4) hours after surgery. Oxidative stress markers concentrations (TBARS, NO2
−, H2O2, O2
− ) as well as antioxidative enzymes (SOD, CAT, and GSH) were analyzed.
QoR-40 total score significantly declined on POD1 and POD2 and returned to baseline levels on POD3 (p<0.001). H2O2 levels significantly decreased from T0 to T3 and then, increased at T4 (p=0,011). Changes of TBARS and H2O2 from T0 to T3 showed significant and negative correlation (r=−0.303, p=0.046). There was no significant correlation between QoR-40 total score and any parameter of oxidative stress response (p>0.05). Changes in TBARS levels from T0 to T3 were statistically significant between the study subgroups primarily due to increase of the concentrations in patients receiving paracetamol (p=0.031). Patients age, duration of surgery and cigarette smoking status showed significant influcences on and association with some oxidative stress response markers (TBARS, O2
−, CAT) (p<0.05).
Women who underwent hysterectomy had significant changes of H2O2 and TBARS activity however, those changes were not associated with changes of QoR-40 total scores during recovery.
Measurement of skin conductance responses to evaluate procedural pain in the perioperative setting
Authors: Svalebjørg Morten , Storm Hanne , Olsen Roy Bjørkholt , Bugge Jan Frederik 
Published: July 2018

Abstract

Background and aims
The subjective nature of pain makes objective, quantitative measurements challenging. The current gold standard for evaluating pain is patient self-reporting using the numeric rating scale (NRS) or Visual Analog Scale. Skin conductance responses per second (SCR) measured in the palmar region reflect the emotional part of the autonomous nervous system. SCR ≥0.20 have been shown to indicate moderate or severe pain in the postoperative setting. We examined whether SCR can detect procedure-related pain before major surgery.

Methods
In 20 patients being prepared for major surgery SCR was recorded before and during arterial cannulation, after induction of anaesthesia, and on the first postoperative day. Self-reported pain was evaluated using NRS. NRS >3 was considered to represent moderate or severe pain.

Results
NRS was 0 [0–0] before arterial cannulation, increasing to 5 [3–6] during arterial cannulation (p<0.05). Before arterial cannulation SCR was 0.27 [0.20–0.27], increasing to 0.33 [0.30–0.37] during arterial cannulation (p<0.01). On the first postoperative day both SCR and reported pain indicated no more than mild pain, SCR 0.13 [0.00–0.20] and NRS 2.0 [0.5–2.0]. The sensitivity of SCR to indicate moderate or severe pain (NRS >3) was 0.93 (0.68–1.0) and specificity was 0.33 (0.25–0.35) when the cut-off established in the postoperative setting (SCR ≥0.20) was used on all data.

Conclusions
SCR increased during arterial cannulation. Before major surgery the SCR was above the threshold demonstrated to indicate pain in the postoperative setting, even without painful stimuli and no reported pain. Using the threshold established for postoperative pain, SCR cannot reliably discriminate between pain and other stressors before major surgery.

Implications
Before major surgery, the diagnosis of moderate or severe pain should not be made based on SCR ≥0.20.
Comorbidities in patients with non-functioning pituitary adenoma: influence of long-term growth hormone replacement
Authors: Hammarstrand Casper , Ragnarsson Oskar , Bengtsson Olivia , Bryngelsson Ing-Liss , Johannsson Gudmundur , Olsson Daniel S 
Published: July 2018

Background
Patients with hypopituitarism have an increased mortality. The aim of this study was to investigate comorbidities including cerebral infarction, type 2 diabetes mellitus (T2DM) and malignant tumors in patients with non-functioning pituitary adenomas (NFPA) with and without growth hormone replacement therapy (GHRT).

Methods
Observational cohort study in patients with NFPA within the western region of Sweden. Subjects were identified through the National Patient Registry and followed between 1987 and 2014. Patient records were reviewed and standardized incidence ratios (SIRs) with 95% CIs for comorbidities were calculated.

Results
In total, 426 patients were included, 206 with GHRT and 219 without. Median (range) follow-up time for patients with and without GHRT was 12.2 (0–24) and 8.2 (0–27) years, respectively. Mean ± s.d. BMI was 28.5 ± 4.5 and 26.5 ± 4.4 for patients with and without GHRT, respectively (P < 0.001). Incidence of cerebral infarction was increased (SIR: 1.39; 95% CI: 1.03–1.84; P = 0.032), with no difference between patients with and without GHRT. SIR for T2DM in patients not receiving GHRT was increased (1.65; 1.06–2.46; P = 0.018), whereas the incidence in patients receiving GHRT was not (0.99; 0.55–1.63; P = 0.99). The incidence of malignant tumors was not increased, either in patients with or without GHRT.

Conclusion
The incidence of cerebral infarction is increased in patients with NFPA irrespective of GHRT. Patients without GHRT had an increased risk of T2DM, whereas patients with GHRT had a normal incidence of T2DM, despite having higher BMI. Incidence of malignant tumors was not increased. Thus, long-term GHRT seems to be safe regarding risk of comorbidities.
Axonal Mitochondria Modulate Neuropeptide Secretion Through the Hypoxic Stress Response in Caenorhabditis elegans
Authors: Zhao Tongtong , Hao Yingsong , Kaplan Joshua M 
Published: July 2018

Abstract
Neurons are highly dependent on mitochondrial function, and mitochondrial damage has been implicated in many neurological and neurodegenerative diseases. Here we show that axonal mitochondria are necessary for neuropeptide secretion in Caenorhabditis elegans and that oxidative phosphorylation, but not mitochondrial calcium uptake, is required for secretion. Oxidative phosphorylation produces cellular ATP, reactive oxygen species, and consumes oxygen. Disrupting any of these functions could inhibit neuropeptide secretion. We show that blocking mitochondria transport into axons or decreasing mitochondrial function inhibits neuropeptide secretion through activation of the hypoxia inducible factor HIF-1. Our results suggest that axonal mitochondria modulate neuropeptide secretion by regulating transcriptional responses induced by metabolic stress.
Transgenerational Effects of Extended Dauer Diapause on Starvation Survival and Gene Expression Plasticity in Caenorhabditis elegans
Authors: Webster Amy K , Jordan James M , Hibshman Jonathan D , Chitrakar Rojin , Baugh L Ryan 
Published: July 2018

Abstract
Organisms respond to environmental conditions by altering gene expression; however, it is unclear if organisms retain epigenetic memory of their ancestors’ environmental conditions. Webster et al. assessed the descendants of two genetically identical...
Phenotypic plasticity is facilitated by epigenetic regulation, and remnants of such regulation may persist after plasticity-inducing cues are gone. However, the relationship between plasticity and transgenerational epigenetic memory is not understood. Dauer diapause in Caenorhabditis elegans provides an opportunity to determine how a plastic response to the early-life environment affects traits later in life and in subsequent generations. We report that, after extended diapause, postdauer worms initially exhibit reduced reproductive success and greater interindividual variation. In contrast, F3 progeny of postdauers display increased starvation resistance and lifespan, revealing potentially adaptive transgenerational effects. Transgenerational effects are dependent on the duration of diapause, indicating an effect of extended starvation. In agreement, RNA-seq demonstrates a transgenerational effect on nutrient-responsive genes. Further, postdauer F3 progeny exhibit reduced gene expression plasticity, suggesting a trade-off between plasticity and epigenetic memory. This work reveals complex effects of nutrient stress over different time scales in an animal that evolved to thrive in feast and famine.
Repertorio Americano: un aporte temprano a la gestión del conocimiento
Authors: Montero Bustabad Pedro 
Published: July 2018

Se analiza cómo la revista Repertorio Americano, con base en las actividades propias de la gestión del conocimiento definidas por Thomas Davenport, realizó una gestión del conocimiento en Latinoamérica. Ya a finales del siglo XX, la Biblioteca Electrónica Scriptorium de la Universidad Nacional es su heredera y facilita su revitalización al digitalizarla.
“Un pueblo”: menosprecio de corte y alabanza de aldea en la poesía de Agustín Acosta
Authors: Febles Jorge 
Published: July 2018

En este artículo se analiza el poema “El pueblo”, del libro La zafra (1926) del escritor cubano Agustín Acosta, en relación con la poesía pastoral y la poesía brucólica, así como la naturaleza, el campesino cubano, el naturalismo y el campo, entre otros aspectos.
Heterotaxy Syndrome and Intestinal Rotation Abnormalities
Authors: Ryerson Lindsay M. , Pharis Scott , Pockett Charissa , Soni Reeni , Fruitman Deborah , Guleserian Kristine J. , Nater Melissa , Raynor Stephen C , Mackie Andrew S. , Dicken Bryan 
Published: July 2018

BACKGROUND:
Infants with heterotaxy syndrome (HS) have abnormal lateralization of organs along the right-left body axis. Intestinal rotation abnormalities (IRAs) are a potential source of morbidity and mortality. For this study, our objective was to prospectively observe a cohort of infants with HS and determine the incidence and natural history of IRA.

METHODS:
Infants ≤6 months of age with HS were enrolled in this prospective observational study. Exclusion criteria were other congenital abnormalities that necessitated abdominal surgery. HS was defined as any arrangement of organs that was not situs solitus or situs inversus along with associated congenital heart disease. The investigation for IRA was at the discretion of each participating center.

RESULTS:
Infants were recruited from January 2012 to December 2016. Thirty-eight infants from 7 institutions were included; 22 infants had right isomerism and 16 infants had left isomerism. Twenty-nine infants (76%) were evaluated for IRAs; 21 of 29 evaluations (72%) were abnormal. Eight infants were investigated because of symptoms, and 21 infants were evaluated routinely. The median age at symptom presentation was 46 days (range: 5–171 days). Seven infants had a Ladd procedure; 4 were prophylactic, with 3 as part of a combined procedure, and 3 were emergent. No child suffered acute midgut volvulus over a median follow-up of 1.6 years (range: 0.06–4.93 years).

CONCLUSIONS:
IRAs are common in infants with HS. Infants with symptoms presented by 6 months of age. There was no failure of expectant management resulting in midgut volvulus during a median follow-up of 1.6 years.
Biallelic Expression of Mucin-1 in Autosomal Dominant Tubulointerstitial Kidney Disease: Implications for Nongenetic Disease Recognition
Authors: Knaup Karl X. , Hackenbeck Thomas , Popp Bernt , Stoeckert Johanna , Wenzel Andrea , Büttner-Herold Maike , Pfister Frederick , Schueler Markus , Seven Didem , May Annette M. , Halbritter Jan , Gröne Hermann-Josef , Reis André , Beck Bodo B. , Amann Kerstin , Ekici Arif B. , Wiesener Michael S. 
Published: July 2018

Background
Providing the correct diagnosis for patients with tubulointerstitial kidney disease and secondary degenerative disorders, such as hypertension, remains a challenge. The autosomal dominant tubulointerstitial kidney disease (ADTKD) subtype caused by MUC1 mutations (ADTKD-MUC1) is particularly difficult to diagnose, because the mutational hotspot is a complex repeat domain, inaccessible with routine sequencing techniques. Here, we further evaluated SNaPshot minisequencing as a technique for diagnosing ADTKD-MUC1 and assessed immunodetection of the disease-associated mucin 1 frameshift protein (MUC1-fs) as a nongenetic technique.

Methods
We re-evaluated detection of MUC1 mutations by targeted repeat enrichment and SNaPshot minisequencing by haplotype reconstruction via microsatellite analysis in three independent ADTKD-MUC1 families. Additionally, we generated rabbit polyclonal antibodies against MUC1-fs and evaluated immunodetection of wild-type and mutated allele products in human kidney biopsy specimens.

Results
The detection of MUC1 mutations by SNaPshot minisequencing was robust. Immunostaining with our MUC1-fs antibodies and an MUC1 antibody showed that both proteins are readily detectable in human ADTKD-MUC1 kidneys, with mucin 1 localized to the apical membrane and MUC1-fs abundantly distributed throughout the cytoplasm. Notably, immunohistochemical analysis of MUC1-fs expression in clinical kidney samples facilitated reliable prediction of the disease status of individual patients.

Conclusions
Diagnosing ADTKD-MUC1 by molecular genetics is possible, but it is technically demanding and labor intensive. However, immunohistochemistry on kidney biopsy specimens is feasible for nongenetic diagnosis of ADTKD-MUC1 and therefore, a valid method to select families for further diagnostics. Our data are compatible with the hypothesis that specific molecular effects of MUC1-fs underlie the pathogenesis of this disease.
Pengaruh Permainan Olahraga Tradisional Bebentengan terhadap Kemampuan Kelincahan Anak Usia 8-9 Tahun
Authors: Nuriman Ramdhan , Kusmaedi Nurlan , Yanto Sumardi 
Published: July 2018

Tujuan penelitian ini untuk mengetahui pengaruh olahraga tradisional bebentengan terhadap kemampuan kelincahan anak usia 8-9 tahun. Populasinya yaitu siswa kelas III pada tahun pelajaran 2013/2014 di SDN 1 Cibodas Kabupaten Bandung Barat, sampel yang digunakan 20 siswa. Menggunakan metode kuasi eksperimen yang dimulai dari observasi, pre-test, treatment, dan post-test. Penelitian ini dilakukan sebanyak delapan kali treatment berikut pretest dan postest. Terdapat kelompok eksperimen dan kelompok kontrol, pada kelompok eksperimen di berikan permainan olahraga tradisioanl bebentengan dan di berikan treatment latihan kelincahan, sedangkan pada kelompok kontrol tidak di berikan permainan olahraga tradisional. Instrumen penelitian berupa lembar kerja siswa dan lembar observasi. Pengolahan dan analisis data menggunakan Statistical Product for Social Science (SPSS) Serie 17. Dalam tahapannya, uji asumsi statistik sebagai berikut : Deskripsi Data, Uji Normalitas Data, Uji Homogenitas Data, Paired Sample T-Test. Ditunjukkan dari kelompok eksperimen adanya peningkatan rata-rata kelincahan sesudah melakukan post-test pada permainan olahraga tradisional bebentengan berdasarkan hipotesis yang telah teruji melalui uji paired sample t-test..
PENGEMBANGAN ALAT UKUR WAKTU REAKSI BERBASIS MICROCONTROLLER
Authors: Permatasari Niluh Ketut NIta , Rusdiana Agus , Ruhayati Yati 
Published: July 2018

Tujuan dalam penelitian ini ialah membuat alat pengukur waktu reaksi tangan berbasis microcontroller. Penelitian ini menggunakan metode Research and Development (R & D). Alat ini menggunakan 9 buah push button, microcontroller, LCD sebagai rangkaian utama. LED yang terdapat dalam push button akan memancarkan cahaya secara acak sebagai stimulus untuk direspon(tekan) lalu informasi dikirimkan ke microcontroller selaku otak pada alat ini untuk diolah dan kemudian ditampilkan pada LCD dalam bentuk timer dan banyaknya stimulus yang berhasil di tekan. Alat akan berhenti secara otomatis setelah 60 detik. Untuk menguji alat ini peneliti menggunakan 30 sampel yang dibagi menjadi 2 kelompok sampel masing-masing 15 orang laki-laki dan 15 orang perempuan. Sampel yang diambil merupakan mahasiswa Ilmu Keolahragaan Universitas Pendidikan Indonesia dengan menggunakan teknik random sampling. Hasil analisis uji coba menggunakan SPSS 18 dengan sub menu frequencies untuk uji deskriptif, One Sample Kolmogorov Smirnov Z untuk uji normalitas, dan Independen Sample t Test untuk uji homogenitas dan perbandingan. Hasil analisis didapat jika kelompok laki-laki dan perempuan tidak memiliki perbedaan yang signifikan. Alat ini memiliki nilai validitas sebesar 0,60 dan reliabilitas 0,624.
PENGEMBANGAN TEKNOLOGI ALAT PELONTAR BOLA TENIS MEJA BERBASIS MICROCONTROLLER
Authors: Syarifatunnisa , , Kusmaedi Nurlan , Rahayu Nur Indri 
Published: July 2018

Penelitian ini bertujuan untuk melakukan pengembangan teknologi alat pelontar bola tenis meja berbasis microcontroller. Pengembangan alat ini dilakukan peneliti agar alat yang dihasilkan lebih murah dari alat-alat yang ada dipasaran. Selain itu alat ini sudah menggunakan microcontroller dengan tipe arduino. Arduino merupakan sebuah platform elektonik yang open source, berbasis pada software dan hardware yang fleksibel dan mudah digunakan. Alat ini memiliki dua menu, diantaranya menu mode yang di dalamnya terdapat empat variasi yaitu easy, medium, hard dan expert kemudian di menu kontrol terdapat submenu forward spin, backward spin, slow normal, fast normal, kanan, tengah dan kiri. Sampel pada penelitian ini adalah 100 buah bola tenis meja yang di uji coba pada alat. Penelitian ini dilakukan untuk menguji validitas dan reabilitas alat. Metode penelitian yang digunakan adalah R&D dengan menggunakan validitas konstruk yaitu pendapat ahli sedangkan uji reabilitas menggunakan SPSS versi 22 yaitu reabillity scale dengan alpha cronbach. Hasil validasi mengungkapkan bahwa alat sudah layak untuk dikembangkan dan hasil uji reabilitas alat (kecepatan dan jarak) memiliki nilai α = 1.000 yang berarti sempurna.
CHARACTER BUILDING MAHASISWA MELALUI MKU PENDIDIKAN JASMANI
Authors: Meyviliano Alvi , Ugelta Surdiniaty 
Published: July 2018

Tujuan penelitian ini yaitu untuk mengetahui gambaran karakter mahasiswa yang mengikuti dan tidak mengikuti perkuliahan pendidikan jasmani dan olahraga. Metode penelitian yang digunakan yaitu metode deskriptif komparatif. Sampel penelitian yang digunakan sebanyak 27 orang dari mahasiswa dan mahasiswi IEKI angkatan 2016. Dengan menggunakan teknik intact group comparison, sampel dibagi dua kelompok. Instrumen penelitian yang di gunakan yaitu berupa angket atau kuesioner mengenai kepercayaan (trustworthinees), tanggung jawab (responsibillity), rasa hormat (respect), rasa adil (fairness), peduli (caring) dan sosial (citizenship). Berdasarkan hasil pengolahan data dan analisis data menggunakan Independent Sample T Test, nilai yang di peroleh untuk mahasiswa yang mengikuti perkuliahan pendidikan jasmani olahraga cukup tinggi, maka dari itu penulis mengambil kesimpulan sebagai berikut: terdapat perbedaan karakter mahasiswa yang dan yang tidak mengikuti mata kuliah umum pendidikan jasmani olahraga.
HUBUNGAN POWER OTOT LENGAN DAN KOORDINASI DENGAN KECEPATAN DAN KETEPATAN SMASH DALAM CABANG OLAHRAGA BULUTANGKIS
Authors: Hermansyah Reza , Imanudin Iman , Badruzaman , 
Published: July 2018

Penelitian ini dilatarbelakangi oleh pentingnya komponen-komponen kondisi fisik terhadap hasil kecepatan dan ketepatan smash dalam cabang olahraga bulutangkis diantaranya power otot lengan dan koordinasi. Tujuan dari penelitian ini untuk mengetahui hubungan antara power otot lengan dan koordinasi dengan hasil kecepatan dan ketepatan smash dalam cabang olahraga bulutangkis. Penelitian ini menggunakan metode deskriptif dengan teknik korelasional. Sampel yang digunakan dalam dalam penelitian ini adalah anggota UKM Bulutangkis UPI Bandung sebanyak 20 orang yang diambil dengan menggunakan teknik purposive sampling. Instrumen yang digunakan dalam penelitian ini adalah tes soft ball throw, tes lempar tangkap bola, dan tes kecepatan dan ketepatan smash. Menunjukkan terdapat hubungan power otot lengan dan koordinasi dengan kecepatan dan ketepatan smash. Dengan hasil penelitian power otot lengan dengan kecepatan smash adalah r = - 0.630, nilai sig. 0.003 < 0.05, dengan ketepatan smash = 0.493, nilai sig. 0.027 < 0.05, hasil penelitian koordinasi kecepatan smash adalah r = -0.461, nilai sig. 0.041 < 0.05, dengan ketepatan smash r = 0.615, nilai sig. 0.004 < 0.05, sedangkan hasil penelitian power otot lengan dan koordinasi secara bersamaan dengan kecepatan smash adalah r = 0.745, nilai sig. 0.001 < 0.05, dengan ketepatan smash r = 0.752, nilai sig. 0.001 < 0.05.
Upaya Meningkatkan Jumlah Waktu Aktif Belajar melalui Penerapan Pengajaran Peer Teaching dalam Pembelajaran Tennis
Authors: Suntoda Andi 
Published: July 2018

Penelitian ini bertujuan untuk memperbaiki proses belajar mengajar Tennis saat perkuliahan terkait Peningkatan Jumlah Waktu Aktif Belajarnya. Berdasarkan observasi awal menunjukkan bahwa penerapannya kurang dapat mengoptimalkan waktu pembelajaran yang tersedia. Metode Penelitian yang digunakan adalah Penelitian Tindakan Kelas (PTK) yang dilakukan dalam dua siklus melalui empat tahapan, yaitu: perencanaan, pelaksanaan, observasi dan refleksi. Subyek penelitiannya adalah mahasiswa PGSD Penjas yang mengambil mata kuliah Tennis Tahun Ajaran 2016/2017 di Semester Genap. Teknik pengumpulan data dilakukan dengan menggunakan observasi, catatan lapangan, dan catatan observer. Teknik analisis data yang digunakan adalah prosentase dari Jumlah Waktu Aktif Belajar di setiap tindakan dan siklusnya. Hasil rekapitulasi peningkatan waktu aktif belajar mahasiswa menunjukkan: Pada observasi awal, jumlah waktu aktivitas belajar mahasiswa menunjukkan sebesar 48%: siklus I tindakan 1 jumlah waktu sebesar 48,30%, siklus I tindakan 2 sebesar 52,50%, siklus I tindakan 3 (Pengulangan tindakan untuk perbaikan) sebesar 55,83%, siklus II tindakan 1 jumlah waktu aktivitas belajar mahasiswa sebesar 58,33%. Berdasarkan perkembangan hasil belajar tersebut, dapat disimpulkan bahwa Penerapan Peer Teaching dapat meningkatkan waktu aktif belajar mahasiswa PGSD Penjas dalam pembelajaran tennis
Aplikasi Program Kebugaran Daya Tahan Kardiovakular Berbasis Android
Authors: Putro Adi Ari , Suherman Adang , Sultoni Kuston 
Published: July 2018

Tujuan penelitian ini adalah merancang aplikasi android sebagai alat bantu program kebugaran daya tahan kardiovaskular. Aplikasi ini terdapat 3 fitur utama yaitu memberi edukasi tentang kebugaran, membantu dalam pengetesan VO2Max, dan membantu dalam pembuatan program latihan kebugaran daya tahan kardiovaskular secara otomatis. Penelitian ini menggunakan metode penelitian Research and Development yang dilakukan dalam enam tahap. Adapun tahap-tahap pengembangan yang dilakukan adalah: (1) Analisis Kebutuhan (2) Desain Aplikasi (3) Pengembangan Aplikasi (4) Produk Awal Apliaksi (5) Evaluasi (6) Produk Akhir. Subjek uji coba dalam penelitian ini adalah 40 anggota unit kegiatan mahasiswa di salah satu universitas. Hasil dari penelitian ini adalah terciptanya aplikasi GO FIT sebagai alat bantu program kebugaran daya tahan kardiovaskular. Kemudian didapat hasil analisis uji coba aplikasi menggunakan skala likert yang diproses melalui excel, kemudian didapat nilai persentase tingkat kelayakan sebesar 88,41 %.