bluuebunny/crossref_metadata_2025_split huggingface dataset:
Why medical tourists choose Turkey as a medical tourism destination?
Authors: Sag Ilhan , Zengul Ferhat Devrim 
Published: November 2018

Purpose
The purpose of this paper is to determine the relationships between the health tourists’ perceptions on decisive factors (i.e. experience, technological infrastructure, flight distance, legal and moral restrictions, touristic attractions, religious similarity, waiting time and price of health tourism) and Turkey as their choice of healthcare tourism destination.

Design/methodology/approach
The data for this empirical study were collected from 288 patients in Turkey, all of whom being health tourists from various countries. Descriptive statistics and Kruskal–Wallis difference tests were utilized for analyses.

Findings
Statistically significant differences were found among health tourists in regards to the geographical regions of their residence. These finding suggest that differences among health tourists in regards to the geographical regions of their residence contributed to the healthcare tourists’ behaviors and health tourism market segmentations in Turkey.

Research limitations/implications
Among the constraints of the study are the time and funding limitations coupled with the limitations on the scale development attempts in the health tourism literature and limitation and biases related to primary data collection. Despite all these limitations, by being the first study exploring the health tourism market segmentations in Turkey, this study contributes to the literature about the perceptions of health tourists and their reasons in choosing Turkey as a health tourism destination.

Practical implications
Determining the Turkey’s health tourism market segmentations will generate the positive effect on the target market which is currently heterogeneous for health tourism operators and intermediary institutions. Moreover, this knowledge would allow the target market to be divided into homogeneous groups, with different marketing mixes for each group. Homogenized groups exhibit unified purchasing behaviors for their needs. Therefore, it is very important for health tourism operators and intermediary institutions to know how the preferences of health tourists from different geographical regions vary.

Originality/value
The paper fulfills a need for advancing the knowledge on the decisive factors in determining Turkey as the health tourism destination by revealing perceptions of health tourists from various geographical regions. This information is very valuable for the Turkey’s healthcare tourism marketing managers who desire to implement the strategies to achieve competitive advantage in the global health tourism market.
Innovation network, technological learning and innovation performance of high-tech cluster enterprises
Authors: Pan Xiongfeng , Song Ma Lin , Zhang Jing , Zhou Guangyou 
Published: November 2018

PurposeThis paper aims to identify the influence of innovation network and technological learning on innovation performance of high-tech cluster enterprises.Design/methodology/approachUsing a questionnaire, data are collected from Dalian High-tech Industrial park in China. In addition, structural equation model is used to identify the influence of innovation network and technological learning on the innovation performance of high-tech cluster enterprise.FindingsThe findings of this study show that the centrality of network location and the strength of the network relationship have a direct positive effect on technology acquisition, technology digestion and technology exploit of high-tech cluster enterprises. Meanwhile, technology acquisition has a direct positive effect on technology digestion, technology digestion has a direct positive effect technology exploit, and technology exploit has a direct positive effect innovation performance of high-tech cluster enterprises.Practical implicationsTo improve innovation performance, high-tech cluster enterprises should not only nurture and optimize innovation networks but also improve technological learning ability.Originality/valueThis paper empirically supports the significant influence of innovation network and technological learning on innovation performance. While the results provide guidance for researchers and practitioners, it also adds value to innovation-related research.
When knowledge management matters: interplay between green human resources and eco-efficiency in the financial service industry
Authors: Moraes Silvana de Souza , Chiappetta Jabbour Charbel Jose , Battistelle Rosane A.G. , Rodrigues Jonny Mateus , Renwick Douglas S.W. , Foropon Cyril , Roubaud David 
Published: November 2018

Purpose
Drawing on the ability–motivation–opportunity theory applied to the greening of service industries, this paper aims to analyze the extent to which green human resource management plays a role in the adoption of eco-efficiency principles in the financial sector. Environmental knowledge management represents one of the key green human resource management components.

Design/methodology/approach
This study conducted a survey with 178 employees working within one of the largest financial banks in Brazil, which has been investing in eco-efficiency for more than ten years.

Findings
On the basis of structural equation modelling, this study has provided the following findings: Among all factors taken into consideration in this study, only environmental training positively influences eco-efficiency; training may be suffering owing to barriers associated with empowerment and teamwork; the eco-efficiency program of the studied company would get benefits if it provided more autonomy to employees; and finally, the eco-efficiency program of the studied bank could be more effective if connected with green teams.

Originality/value
To date, this is the first work that relates – with empirical evidence from Brazil – GHRM and eco-efficiency in the financial service industry.
Design-for-variety and operational performance
Authors: Boer Henrike , Boer Harry 
Published: November 2018

Purpose
Design-for-variety (DFV) practices aim to help manufacturers to manage and mitigate the negative impact of product variety on operational performance. Theory suggests that designing products according to DFV practices increases operational performance by allowing more efficient processing of products, capitalizing on commonalities and by supporting cross-functional and cross-boundary coordination through simplifying product designs. The purpose of this paper is to investigate the latter proposition, and especially the mediating role of internal, supplier and customer integration in the relationship between DFV and operational performance.

Design/methodology/approach
Data collected in 2014 among 702 manufacturers from 22 countries as part of the 6th International Manufacturing Strategy Survey are analyzed through mediated regression analysis using SPSS 25, AMOS and PROCESS v3.1 software.

Findings
DFV affects cost/speed, quality, delivery, flexibility and service performance positively. Except for the role of customer integration in the DFV-cost/speed relationship, internal, supplier and customer integration partially mediate the relationship between DFV and operational performance.

Practical implications
In addition to allowing a more efficient processing of products, the positive effect of DFV on performance is also explained by the fact that DFV practices support cross-functional and supply chain integration. These practices allow manufacturers to create a set of design rules easily understood and communicated within and across organizational boundaries.

Originality/value
While previous research tends to consider one DFV practice and limited sets of integration mechanisms and performance dimensions, this paper consolidates the most common DFV practices into one construct and encompasses the three forms of integration and six performance dimensions dominating the DFV literature.
Linking leader–follower proactive personality congruence to creativity
Authors: Roopak Kumar , Mishra Sushanta Kumar , Sikarwar Ekta 
Published: November 2018

PurposeDrawing from the literature on person–environment fit and proactive personality, the purpose of this paper is to empirically examine whether congruence between the proactive personality of a leader and his/her follower is facilitative/inhibitive of creativity of the follower.Design/methodology/approachData were collected in two waves from 355 followers and 36 corresponding leaders working in a large manufacturing company in India. Hypotheses were tested using polynomial regression analysis and response surface method.FindingsThe results indicate that leader–follower congruence in proactive personality is more likely to encourage followers’ creativity. Moreover, leader–follower congruence at higher levels of proactive personality showed higher levels of followers’ creativity than when dyads are congruent at lower levels.Practical implicationsFindings suggest that human resource management in organizations should consider matching leaders’ proactive personality with that of followers’ to foster employee creativity. This is critical from the perspective of recruitment and dyad formulation for jobs that demand creativity.Originality/valueResearch examining why and how congruence in personal characteristics between a leader and his/her follower foster followers’ creativity is at best scant. The study is a novel attempt to examine the effect of congruence in leader–follower proactive personalities on workplace creativity of the follower.
Risk of psychiatric disorders in rosacea: A nationwide, population‐based, cohort study in Taiwan
Authors: Hung Chih‐Tsung , Chiang Chien‐Ping , Chung Chi‐Hsiang , Tsao Chang‐Huei , Chien Wu‐Chien , Wang Wei‐Ming 
Published: November 2018

AbstractRosacea has been reported to be associated with psychiatric disorders. Nevertheless, a nationwide study of the relationship between rosacea and comorbid psychiatric diseases in an Asian population has not been conducted. The aim of this study was to clarify the role of rosacea in the various psychiatric disorders by using a nationwide database in Taiwan. Data were obtained from the National Health Insurance Research Database of Taiwan from 2000 to 2013. In total, 7881 patients with rosacea and 31 524 age‐ and sex‐matched controls were enrolled. Patients with rosacea tended to have more coexisting psychiatric disorders. After adjusting for age, sex, comorbidity and residence/regions, the adjusted hazard ratio (HR) of psychiatric disorders for patients with rosacea was 2.761 (95% CI = 2.650–2.877, P < 0.001). Among them, the highest adjusted HR are phobic disorder and obsessive–compulsive disorder of 7.841 (95% CI = 7.526–8.170, P < 0.001) and 6.389 (95% CI = 6.132–6.657, P < 0.001), respectively. The National Health Insurance Research Database of Taiwan does not include the information about rosacea subtypes, severity and laboratory parameters. In conclusion, rosacea is related to various psychiatric disorders. In addition to anxiety and depression, patients are also at increased risk of phobic disorder and obsessive–compulsive disorder.
Review and meta‐analysis found that prenatal folic acid was associated with a 58% reduction in autism but had no effect on mental and motor development
Authors: Iglesias Vázquez Lucía , Canals Josefa , Arija Victoria 
Published: November 2018

AbstractAimThe impact of prenatal folic acid on children's neurodevelopment and the risk of autism spectrum disorder (ASD) remain unclear and this review and meta‐analysis aimed to quantify any associations.MethodsWe systematically searched PubMed, Scopus and The Cochrane Library until June 2018 with no language restrictions. Standardised mean differences and odds ratio with 95% confidence intervals are used to describe any associations between folic acid and mental development, motor development and ASD.ResultsThe search strategy identified 647 papers and 16 were finally included in the meta‐analysis after the application of the exclusion criteria. These provided a total cohort size of 756 365 children aged 11 months to 15 years from 10 countries. The main finding was that prenatal use of folic acid was associated with a 58% reduction in the risk of ASD in children. We were surprised that better scores for mental development were associated with low prenatal exposure to folic acid.ConclusionAlthough the results should be interpreted with caution, they showed that routine prenatal supplements of folic acid were associated with significantly lower levels of ASD. Further studies are needed to reach a firm conclusion, given the multifactorial aetiology of neurodevelopment.
Na+/Ca2+ exchanger 1 is a key mechanosensitive molecule of the esophageal myenteric neurons
Authors: Dong Hui , Tang Bo , Jiang Yanfen , Mittal Ravinder K. 
Published: November 2018

AbstractAimOur earlier studies showed that mechanical stretch activates inhibitory motor neurons of the oesophagus; however, the underlying molecular mechanisms are unclear. Here, we sought to examine if Na+/Ca2+ exchanger 1 (NCX1) is responsible for the mechanosensitivity in the esophageal myenteric neurons (EMN) of rats and humans.MethodsThe function of NCX1 in primary culture of neurons was determined using calcium imaging, and mechanosensitivity was tested using osmotic stretch and direct mechanical stretch. Axial stretch‐induced relaxation of the lower esophageal sphincter (LES) was also studied in vivo in rats.ResultsThe expression and co‐localization of NCX1 with nNOS were identified in the EMN from both rats and humans. The extracellular Ca2+ entry caused by ATP through purinergic signalling in the rat EMN was significantly inhibited by selective NCX blockers. Removal of extracellular Na+ to activate the Ca2+ entry mode of NCX1 induced an increase in the cytoplasmic calcium ([Ca2+]cyt), which was attenuated by NCX blockers. Osmotic stretch and mechanical stretch‐induced [Ca2+]cyt signalling in the rat and human EMN were attenuated by NCX blockers as well as specific NCX1 knockdown. Osmotic stretch and mechanical stretch also induced [Ca2+]cyt signalling in the Chinese hamster ovary (CHO) cells with NCX1 over‐expression, which was attenuated by NCX blockers. Finally, NCX blockade inhibited axial stretch‐activated LES relaxation in vivo experiments in the rats.ConclusionsWe demonstrate a novel NCX1/Ca2+ pathway in the mechanosensitive neurons of rat and human oesophagus, which may provide a potential therapeutic target for the treatment of oesophageal motility disorders.
How do we identify people at high risk of Type 2 diabetes and help prevent the condition from developing?
Authors: Fagg J. , Valabhji J. 
Published: November 2018

AimsTo review the evidence regarding the identification of those at high risk of Type 2 diabetes and the conceptual and clinical criteria defining high risk, the prevention or delay of onset of Type 2 diabetes through lifestyle interventions, and the evolution of evidence from efficacy trials, through effectiveness trials in real‐world settings, to implementation programmes at scale.MethodThe wide scope of this review precluded a systematic approach, therefore, we present a narrative review that highlights key themes and contemporary developments, drawing on landmark studies, previous systematic and expert reviews, and previous meta‐analyses.ResultsWhile the diagnostic thresholds for Type 2 diabetes are accepted, international consensus on whether, and how, to classify those at high risk of Type 2 diabetes has not been achieved. There is ongoing debate about which laboratory test to use and each test's corresponding inclusion threshold, about where the balance of clinical benefits and harms sit when defining thresholds, and about how affordability of subsequent preventative interventions might influence the derivation of such thresholds within any particular population. A remarkable international effort has seen the evolution of interventions for those at high risk move from efficacy trials, through effectiveness trials, to implementation at scale, and the evidence supporting each stage is reviewed.ConclusionsTo achieve healthcare system sustainability, many countries are now focusing on disease prevention. To complement population‐level interventions that address the obesogenic environment, lifestyle interventions that empower individuals at high risk of Type 2 diabetes to modify this risk beneficially are now being implemented at scale.
Effects of livestock grazing on grassland carbon storage and release override impacts associated with global climate change
Authors: Zhou Guiyao , Luo Qin , Chen Yajie , He Miao , Zhou Lingyan , Frank Douglas , He Yanghui , Fu Yuling , Zhang Baocheng , Zhou Xuhui 
Published: November 2018

AbstractPredicting future carbon (C) dynamics in grassland ecosystems requires knowledge of how grazing and global climate change (e.g., warming, elevated CO2, increased precipitation, drought, and N fertilization) interact to influence C storage and release. Here, we synthesized data from 223 grassland studies to quantify the individual and interactive effects of herbivores and climate change on ecosystem C pools and soil respiration (Rs). Our results showed that grazing overrode global climate change factors in regulating grassland C storage and release (i.e., Rs). Specifically, grazing significantly decreased aboveground plant C pool (APCP), belowground plant C pool (BPCP), soil C pool (SCP), and Rs by 19.1%, 6.4%, 3.1%, and 4.6%, respectively, while overall effects of all global climate change factors increased APCP, BPCP, and Rs by 6.5%, 15.3%, and 3.4% but had no significant effect on SCP. However, the combined effects of grazing with global climate change factors also significantly decreased APCP, SCP, and Rs by 4.0%, 4.7%, and 2.7%, respectively but had no effect on BPCP. Most of the interactions between grazing and global climate change factors on APCP, BPCP, SCP, and Rs were additive instead of synergistic or antagonistic. Our findings highlight the dominant effects of grazing on C storage and Rs when compared with the suite of global climate change factors. Therefore, incorporating the dominant effect of herbivore grazing into Earth System Models is necessary to accurately predict climate–grassland feedbacks in the Anthropocene.
School lunch—Children’s space or teachers’ governmentality?
Authors: Fossgard Eldbjørg , Wergedahl Hege , Bjørkkjær Tormod , Holthe Asle 
Published: November 2018

AbstractThis article discusses social aspects of school lunches in Norway. How do 11‐year‐old students experience and perceive their packed lunches and lunch breaks and to what extent is the lunch break a space for children's sociality or an area for teachers’ governmentality? The study is based on 25 focus group discussions and drawing and writing assignments with 165 participants. A large proportion of the students expressed that they appreciated their packed lunches because they could decide for themselves what and how much to eat. Additionally, shortage of time and disturbance and noise in the classroom could ruin a good meal. The main issue that the students raised in relation to our question of sociality was with whom they could sit and eat their packed lunches. This finding underlines the importance of considering the emotional dimensions of eating and that commensal eating is not dependent on sharing the same food. The children experienced that the lunch break was governed by an adult agenda in which they had limited opportunities to create their own spaces.
Prophages in Salmonella enterica: a driving force in reshaping the genome and physiology of their bacterial host?
Authors: Wahl Astrid , Battesti Aurélia , Ansaldi Mireille 
Published: November 2018

SummaryThanks to the exponentially increasing number of publicly available bacterial genome sequences, one can now estimate the important contribution of integrated viral sequences to the diversity of bacterial genomes. Indeed, temperate bacteriophages are able to stably integrate the genome of their host through site‐specific recombination and transmit vertically to the host siblings. Lysogenic conversion has been long acknowledged to provide additional functions to the host, and particularly to bacterial pathogen genomes where prophages contribute important virulence factors. This review aims particularly at highlighting the current knowledge and questions about lysogeny in Salmonella genomes where functional prophages are abundant, and where genetic interactions between host and prophages are of particular importance for human health considerations.
NRT1.1B improves selenium concentrations in rice grains by facilitating selenomethinone translocation
Authors: Zhang Lianhe , Hu Bin , Deng Kun , Gao Xiaokai , Sun Guoxin , Zhang Zhengli , Li Peng , Wang Wei , Li Hua , Zhang Zhihua , Fu Zihao , Yang Jinyong , Gao Shaopei , Li Legong , Yu Feiyan , Li Youjun , Ling Hongqing , Chu Chengcai 
Published: November 2018

SummarySelenium (Se) is an essential trace element for humans and other animals, yet approximately one billion people worldwide suffer from Se deficiency. Rice is a staple food for over half of the world's population that is a major dietary source of Se. In paddy soils, rice roots mainly take up selenite. Se speciation analysis indicated that most of the selenite absorbed by rice is predominantly transformed into selenomethinone (SeMet) and retained in roots. However, the mechanism by which SeMet is transported in plants remains largely unknown. In this study, SeMet uptake was found to be an energy‐dependent symport process involving H+ transport, with neutral amino acids strongly inhibiting SeMet uptake. We further revealed that NRT1.1B, a member of rice peptide transporter (PTR) family which plays an important role in nitrate uptake and transport in rice, displays SeMet transport activity in yeast and Xenopus oocyte. The uptake rate of SeMet in the roots and its accumulation rate in the shoots of nrt1.1b mutant were significantly repressed. Conversely, the overexpression of NRT1.1B in rice significantly promoted SeMet translocation from roots to shoots, resulting in increased Se concentrations in shoots and rice grains. With vascular‐specific expression of NRT1.1B, the grain Se concentration was 1.83‐fold higher than that of wild type. These results strongly demonstrate that NRT1.1B holds great potential for the improvement of Se concentrations in grains by facilitating SeMet translocation, and the findings provide novel insight into breeding of Se‐enriched rice varieties.
Daily Maximum Erythemal Dose Rates in the Tropics
Authors: Silva Abel A. , Yamamoto Ana L. C. , Corrêa Marcelo P. 
Published: November 2018

AbstractThe maximum erythemal dose rate (EDRmax) at the Earth's surface tends to occur at local noon. However, clouds can make the timing of EDRmax significantly away from local noon. In fact, EDRmax and its time of occurrence depend mainly on the solar zenith angle at noon (SZAn), site's altitude, the total ozone column (TOC), cloud cover, cloud genera and aerosols. This work depicts the daily incidence of EDRmax for Belo Horizonte (19.92°S, 43.94°W, 858 m a.s.l.) in the Southern Hemisphere tropics for a period of five years (2005–2010). Daily values of EDRmax ranged from 0.063 W m−2 (1σ > 6.9%, Moderate UV‐Index of 3, winter) to 0.486 W m−2 (Extreme UVI of 19, summer). Indicative values of EDRmax for cloudless days were 0.336 W m−2 (summer, TOC = 258 Dobson Units), 0.311 W m−2 (fall, 260 DU), 0.253 W m−2 (spring, 274 DU) and 0.143 W m−2 (winter, 246 DU). Radiation enhancement events by clouds made EDRmax up to 45% higher than the reference EDRmax for cloudless summer skies at a time resolution of a few minutes. The main cloud genera to be associated with such events are Cumulus, Altocumulus, Altostratus and Stratocumulus. The EDR can also be significantly affected by aerosols, which attenuated on average 0.031 W m−2 (22%) of the erythemal UV in a case study at the site.