bluuebunny/crossref_metadata_2025_split huggingface dataset:
A laddering study of motivational complexities in mobile shopping
Authors: Park Ha Eun , Yap Sheau Fen Crystal , Makkar Marian 
Published: March 2019

Purpose
The purpose of this paper is to uncover the motivational tensions underlying mobile shopping (m-shopping) behaviours. The authors focus on consumer motivations and the pursuit of life end goals with respect to m-shopping.

Design/methodology/approach
Based on the means-end chain theory, hard-laddering approach was used to elicit associations between attributes, consequences and values from 251 online participants. Content analysis was used to develop a hierarchical value map “mapping” these associations to uncover underlying values for m-shopping.

Findings
Mobile shoppers are motivated by their self-actualisation needs (self-focused) and/or social needs (other-focused). Participants’ response contradictions reflected internal complexities and ambivalences during their purchasing decisions. Decisions are based on their concerns around security, time, technological or financial.

Practical implications
This study provides managerial insights into retail marketing and strategies. Marketers should consider creating user-friendly applications by researching the customer journey experience, heightening security measures and ensuring that added-value offers are clearly communicated to meet consumers’ personal values and motivations.

Originality/value
The paper presents an original conceptual contribution of personal values related to m-shopping as desires for self-empowerment, altruism and relationships with others, self-fulfilment and hedonism and possible consumer internal conflicts.
Normalizing covert surveillance: the subterranean world of policing
Authors: Loftus Bethan 
Published: March 2019

AbstractIn this article, I draw on data derived from an ethnographic field study of covert policing in the United Kingdom to demonstrate that the deployment of covert surveillance has become normalized, both in policing thought and operational practice. In a break with earlier patterns, the methods of covert surveillance are used extensively and are no longer regarded as a tactic of last resort. Covert policing is well anchored within organizational arrangements, empowered by a series of internal rationales mobilized to justify the expansion of covert tactics over and above more traditional, overt forms. The building of intrusive and exceptional policing practices within mundane contexts, I argue, is one of the ways the police have adapted to a broader policing environment characterized by public scepticism and distrust. Policing relies on the invisibility and low profile that comes with covert work, in order to govern contemporary concerns of crime and insecurity without the conflicts which can accompany – and trouble – overt policing practices. As mainstream policing becomes an increasingly extroverted enterprise, introverted forms of policing have come to the fore.
A scalable model of vegetation transitions using deep neural networks
Authors: Rammer Werner , Seidl Rupert 
Published: March 2019

Abstract

In times of rapid global change, anticipating vegetation changes and assessing their impacts is of key relevance to managers and policy makers. Yet, predicting vegetation dynamics often suffers from an inherent scale mismatch, with abundant data and process understanding being available at a fine spatial grain, but the relevance for decision‐making is increasing with spatial extent.

We present a novel approach for scaling vegetation dynamics (SVD), using deep learning to predict vegetation transitions. Vegetation is discretized into a large number (103–106) of potential states based on its structure, composition and functioning. Transition probabilities between states are estimated via a deep neural network (DNN) trained on observed or simulated vegetation transitions in combination with environmental variables. The impact of vegetation transitions on important ecological indicators is quantified by probabilistically linking attributes such as carbon storage and biodiversity to vegetation states.

Here, we describe the SVD approach and present results of applying the framework in a meta‐modelling context. We trained a DNN using simulations of a process‐based forest landscape model for a complex mountain forest landscape under different climate scenarios. Subsequently, we evaluated the ability of SVD to project long‐term vegetation dynamics and the resulting changes in forest carbon storage and biodiversity. SVD captured spatial (e.g. elevational gradients) and temporal (e.g. species succession) patterns of vegetation dynamics well, and responded realistically to changing environmental conditions. In addition, we tested the computational efficiency of the approach, highlighting the utility of SVD for country‐ to continental scale applications.

SVD is the—to our knowledge—first vegetation model harnessing deep neural networks. The approach has high predictive accuracy and is able to generalize well beyond training data. SVD was designed to run on widely available input data (e.g. vegetation states defined from remote sensing, gridded global climate datasets) and exceeds the computational performance of currently available highly optimized landscape models by three to four orders of magnitude. We conclude that SVD is a promising approach for combining detailed process knowledge on fine‐grained ecosystem processes with the increasingly available big ecological datasets for improved large‐scale projections of vegetation dynamics.
Dapsone‐ and nitroso dapsone‐specific activation of T cells from hypersensitive patients expressing the risk allele HLA‐B*13:01
Authors: Zhao Qing , Alhilali Khetam , Alzahrani Abdulaziz , Almutairi Mubarak , Amjad Juwaria , Liu Hong , Sun Yonghu , Sun Lele , Zhang Huimin , Meng Xiaoli , Gibson Andrew , Ogese Monday O. , Kevin Park B. , Liu Jianjun , Ostrov David A. , Zhang Furen , Naisbitt Dean J. 
Published: March 2019

AbstractBackgroundResearch into drug hypersensitivity associated with the expression of specific HLA alleles has focussed on the interaction between parent drug and the HLA with no attention given to reactive metabolites. For this reason, we have studied HLA‐B*13:01‐linked dapsone hypersensitivity to (a) explore whether the parent drug and/or nitroso metabolite activate T cells and (b) determine whether HLA‐B*13:01 is involved in the response.MethodsPeripheral blood mononuclear cells (PBMC) from six patients were cultured with dapsone and nitroso dapsone, and proliferative responses and IFN‐γ release were measured. Dapsone‐ and nitroso dapsone‐specific T‐cell clones were generated and phenotype, function, HLA allele restriction, and cross‐reactivity assessed. Dapsone intermediates were characterized by mass spectrometry.ResultsPeripheral blood mononuclear cells from six patients and cloned T cells proliferated and secreted Th1/2/22 cytokines when stimulated with dapsone (clones: n = 395; 80% CD4+ CXCR3hiCCR4hi, 20% CD8+CXCR3hiCCR4hiCCR6hiCCR9hiCCR10hi) and nitroso dapsone (clones: n = 399; 78% CD4+, 22% CD8+ with same chemokine receptor profile). CD4+ and CD8+ clones were HLA class II and class I restricted, respectively, and displayed three patterns of reactivity: compound specific, weakly cross‐reactive, and strongly cross‐reactive. Nitroso dapsone formed dimers in culture and was reduced to dapsone, providing a rationale for the cross‐reactivity. T‐cell responses to nitroso dapsone were dependent on the formation of a cysteine‐modified protein adduct, while dapsone interacted in a labile manner with antigen‐presenting cells. CD8+ clones displayed an HLA‐B*13:01‐restricted pattern of activation.ConclusionThese studies describe the phenotype and function of dapsone‐ and nitroso dapsone‐responsive CD4+ and CD8+ T cells from hypersensitive patients. Discovery of HLA‐B*13:01‐restricted CD8+ T‐cell responses indicates that drugs and their reactive metabolites participate in HLA allele‐linked forms of hypersensitivity.
Behavioural and physiological assessments of dimethyl trisulfide treatment for acute oral sodium cyanide poisoning
Authors: Rice Nathaniel C. , Rauscher Noah A. , Wilkins William L. , Lippner Dennean S. , Rockwood Gary A. , Myers Todd M. 
Published: March 2019

AbstractSodium cyanide (NaCN) is a commonly and widely used industrial and laboratory chemical that is highly toxic. Its availability and rapid harmful/lethal effects combine to make cyanide a potential foodborne/waterborne intentional‐poisoning hazard. Effective antidotes to cyanide poisoning are currently approved only for intravenous administration. Therefore, an effective cyanide antidote that can be administered intramuscularly in pre‐hospital and/or mass‐casualty settings is needed. Dimethyl trisulfide (DMTS) is a naturally occurring substance used as a flavour enhancer in foods. DMTS has shown antidotal efficacy in cyanide poisoning and is thought to act as both a sulphur donor and partial methaemoglobin inducer. In this study, an intramuscular injection of DMTS (6.25‐200 mg/kg) was given to rats 1 minute after an oral dose of NaCN (98.2 mg/kg; twice the median lethal dose) to test the antidotal efficacy and safety of DMTS treatment. Toxic signs and survival were examined along with behavioural function (up to 30 hour after ingestion) using a previously established operant behavioural model. A large range of DMTS doses (6.25‐100 mg/kg) increased survival after oral cyanide poisoning, and the lower DMTS doses (6.25‐25 mg/kg) also proved to be behaviourally and physiologically safe. Larger DMTS doses (50‐200 mg/kg) produced side effects (ie, inflammation and limping) that were more severe and protracted than those observed at lower DMTS doses. The 25 mg/kg DMTS proved to be the most efficacious (increasing survival from 20% to 75%) and also produced minimal side effects (eg, inflammation) that resolved within 24‐72 hour. Thus, DMTS shows promise as an intramuscularly administered cyanide antidote useful for prompt pre‐hospital or mass‐casualty emergency medical treatment.
Heat shock factor 1 in cancer‐associated fibroblasts is a potential prognostic factor and drives progression of oral squamous cell carcinoma
Authors: Wang Qiong , Zhang Yu‐Chao , Zhu Li‐Fang , Pan Lu , Yu Miao , Shen Wei‐Li , Li Bang , Zhang Wei , Liu Lai‐Kui 
Published: March 2019

Heat shock factor 1 (HSF1) is highly expressed in various malignancies and is a potential modulator of tumor progression. Emerging evidence suggests that HSF1 activation in stromal cells is closely related to poor patient prognosis. However, the role of HSF1 in oral squamous cell carcinoma (OSCC) remains elusive. We aimed to investigate the function of HSF1 in cancer‐associated fibroblasts (CAFs) of the tumor microenvironment (TME) and in tumor development. In the present study, we found that HSF1 was highly expressed in both CAFs and tumor cells, and was significantly correlated with poor prognosis and overall survival. Moreover, HSF1 overexpression in CAFs resulted in a fibroblast‐like phenotype of Cal27 cells, induced epithelial‐mesenchymal transition (EMT), and promoted proliferation, migration and invasion in Cal27 cells. HSF1 knockdown attenuated features of CAFs and reduced EMT, proliferation, migration and invasion in Cal27 cells. Furthermore, HSF1 in CAFs promoted tumor growth in nude mice. Taken together, these data suggest that HSF1 expression in CAFs drive OSCC progression, and could serve as an independent prognostic marker of patients with OSCC. Thus, HSF1 is a potent mediator of OSCC malignancy.
Targeting HOX/PBX dimer formation as a potential therapeutic option in esophageal squamous cell carcinoma
Authors: Shen Lu‐Yan , Zhou Ting , Du Ya‐Bing , Shi Qi , Chen Ke‐Neng 
Published: March 2019

Homeobox genes are known to be classic examples of the intimate relationship between embryogenesis and tumorigenesis, which are a family of transcriptional factors involved in determining cell identity during early development, and also dysregulated in many malignancies. Previously, HOXB7, HOXC6 and HOXC8 were found abnormally upregulated in esophageal squamous cell carcinoma (ESCC) tissues compared with normal mucosa and seen as poor prognostic predictors for ESCC patients, and were shown to promote cell proliferation and anti‐apoptosis in ESCC cells. These three HOX members have a high level of functional redundancy, making it difficult to target a single HOX gene. The aim of the present study was to explore whether ESCC cells are sensitive to HXR9 disrupting the interaction between multiple HOX proteins and their cofactor PBX, which is required for HOX functions. ESCC cell lines (KYSE70, KYSE150, KYSE450) were treated with HXR9 or CXR9, and coimmunoprecipitation and immunofluorescent colocalization were carried out to observe HOX/PBX dimer formation. To further investigate whether HXR9 disrupts the HOX pro‐oncogenic function, CCK‐8 assay and colony formation assay were carried out. Apoptosis was assessed by flow cytometry, and tumor growth in vivo was investigated in a xenograft model. RNA‐seq was used to study the transcriptome of HXR9‐treated cells. Results showed that HXR9 blocked HOX/PBX interaction, leading to subsequent transcription alteration of their potential target genes, which are involved in JAK‐signal transducer and activator of transcription (STAT) activation and apoptosis inducement. Meanwhile, HXR9 showed an antitumor phenotype, such as inhibiting cell proliferation, inducing cell apoptosis and significantly retarding tumor growth. Therefore, it is suggested that targeting HOX/PBX may be a novel effective treatment for ESCC.
Transanal total mesorectal excision: how are we doing so far?
Authors: Sparreboom C. L. , Komen N. , Rizopoulos D. , van Westreenen H. L. , Doornebosch P. G. , Dekker J. W. T. , Menon A. G. , Tuynman J. B. , Daams F. , Lips D. , van Grevenstein W. M. U. , Karsten T. M. , Lange J. F. , D'Hoore A. , Wolthuis A. M. 
Published: March 2019

AbstractAimThis subgroup analysis of a prospective multicentre cohort study aims to compare postoperative morbidity between transanal total mesorectal excision (TaTME) and laparoscopic total mesorectal excision (LaTME).MethodThe study was designed as a subgroup analysis of a prospective multicentre cohort study. Patients undergoing TaTME or LaTME for rectal cancer were selected. All patients were followed up until the first visit to the outpatient clinic after hospital discharge. Postoperative complications were classified according to the Clavien–Dindo classification and the comprehensive complication index (CCI). Propensity score matching was performed.ResultsIn total, 220 patients were selected from the overall prospective multicentre cohort study. After propensity score matching, 48 patients from each group were compared. The median tumour height for TaTME was 10.0 cm (6.0–10.8) and for LaTME was 9.5 cm (7.0–12.0) (P = 0.459). The duration of surgery and anaesthesia were both significantly longer for TaTME (221 vs 180 min, P < 0.001, and 264 vs 217 min, P < 0.001). TaTME was not converted to laparotomy whilst surgery in five patients undergoing LaTME was converted to laparotomy (0.0% vs 10.4%, P = 0.056). No statistically significant differences were observed for Clavien–Dindo classification, CCI, readmissions, reoperations and mortality.ConclusionThe study showed that TaTME is a safe and feasible approach for rectal cancer resection. This new technique obtained similar postoperative morbidity to LaTME.
Mental models for conservation research and practice
Authors: Moon Katie , Guerrero Angela M. , Adams Vanessa. M. , Biggs Duan , Blackman Deborah A. , Craven Luke , Dickinson Helen , Ross Helen 
Published: March 2019

AbstractConservation practice requires an understanding of complex social‐ecological processes of a system and the different meanings and values that people attach to them. Mental models research offers a suite of methods that can be used to reveal these understandings and how they might affect conservation outcomes. Mental models are representations in people's minds of how parts of the world work. We seek to demonstrate their value to conservation and assist practitioners and researchers in navigating the choices of methods available to elicit them. We begin by explaining some of the dominant applications of mental models in conservation: revealing individual assumptions about a system, developing a stakeholder‐based model of the system, and creating a shared pathway to conservation. We then provide a framework to “walk through” the stepwise decisions in mental models research, with a focus on diagram‐based methods. Finally, we discuss some of the limitations of mental models research and application that are important to consider. This work extends the use of mental models research in improving our ability to understand social‐ecological systems, creating a powerful set of tools to inform and shape conservation initiatives.
Randomized controlled study of the prediction of diminutive/small colorectal polyp histology using didactic versus computer‐based self‐learning module in gastroenterology trainees
Authors: Smith Samuel C. L. , Saltzman John , Shivaji Uday N. , Lethebe Brendan C. , Cannatelli Rosanna ,   The Birmingham Colonic Polyp Characterisation Group, Ghosh Subrata , Iacucci Marietta 
Published: March 2019

Background and AimThe aim of this randomized trial was to evaluate the performance of self‐training versus didactic training in order to increase the diagnostic accuracy of diminutive/small colonic polyp histological prediction by trainees.MethodsSixteen trainees reviewed 78 videos (48 iSCAN‐OE and 30 NBI) of diminutive/small polyps in a pretraining assessment. Trainees were randomized to receive computer‐based self‐learning (n = 8) or didactic training (n = 8) using identical teaching materials and videos. The same 78 videos, in a different randomized order, were assessed. The NICE (NBI International Colorectal Endoscopic) and SIMPLE (Simplified Identification Method for Polyp Labeling during Endoscopy) classification systems were used to classify diminutive/small polyps.ResultsA higher proportion of high‐confidence predictions of polyps was made by the self‐training group versus the didactic group using both the SIMPLE classification (77.1% [95% CI 73.4–80.3] vs 69.9% [95% CI 66.1–73.5%] [P = 0.005]) and the NICE classification (77% [95% CI 73.2–80.4%] vs 69.8% [95% CI 66–73.4%] [P = 0.006]). When using NICE, sensitivity of the self‐training group compared with the didactic group was 72% versus 83% (P = 0.0005), and the accuracy was 66.1% versus 69.1%. The training improved the confidence of participants and SIMPLE was preferred over NICE.ConclusionSelf‐learning for the prediction of diminutive/small polyp histology is a method of training that can achieve results similar to didactic training. Availability of adequate self‐learning teaching modules could enable widespread implementation of optical diagnosis in clinical practice.
The AppVox mobile application, a tool for speech and language training sessions
Authors: Rocha Tânia , Gonçalves Cirano , Fernandes Hugo , Reis Arsénio , Barroso João 
Published: March 2019

AbstractAppVox is a mobile application that provides support for children with speech and language impairments in their speech therapy sessions, while also allowing autonomous training at home. The application simulates a vocalizer with an audio stimulus feature, which can be used to train and amend the pronunciation of specific words through repetition. In this paper, we aim to present the development of the application as an assistive technology option, by adding new features to the vocalizer as well as assessing it as a usable option for daily training interaction for children with speech and language impairments. In this regard, we invited 15 children with speech and language impairments and 20 with no impairments to perform training activities with the application. Likewise, we asked three speech therapists and three usability experts to interact, assess, and give their feedback. In this assessment, we include the following parameters: successful conclusion of the training tasks (effectiveness); number of errors made, as well as number and type of difficulties found (efficiency); and the acceptance and level of comfort in completing the requested tasks (satisfaction). Overall, the results showed that children conclude the training tasks successfully and helped to improve their language and speech capabilities. Therapists and children gave positive feedback to the AppVox interface.
Psychological Well‐Being and Parent‐Child Relationship Quality in Relation to Child Autism: An Actor‐Partner Modeling Approach
Authors: Hickey Emily J. , Hartley Sigan L. , Papp Lauren 
Published: March 2019

Parents of children with autism spectrum disorder (ASD) often report poor psychological well‐being, including a high level of parenting stress and depressive symptoms. Little is known about the extent to which poor parent psychological well‐being alters the emotional quality of the parent‐child relationship in a context of child ASD. This study examined the association between actor (one's own) and partner (one's partner's) level of parenting stress and depressive symptoms and the emotional quality of the parent‐child relationship using a Five Minute Speech Sample (FMSS) in 150 families of children with ASD, aged 5–12 years (85.7% male). Mothers and fathers were aged 38.69 (SD = 5.62) and 40.76 (SD = 6.19), respectively; 76% of mothers and 68% of fathers had a college degree. Structural equation modeling, using Analysis of Moment Structures software, was used to test Actor‐Partner Interdependence Models. Results indicated that mother's level of parenting stress and depressive symptoms were associated with her own FMSS Warmth and Criticism toward the child with ASD 12 months later in negative and positive directions. Mother's level of parenting stress was also negatively associated with father's FMSS Warmth toward the child with ASD 12 months later. Finally, father's level of parenting stress was positively associated with his FMSS Criticism toward the child with ASD. Overall, findings indicate that the mother‐child and father‐child relationship are both impacted by parent psychological well‐being in families of children with ASD; however, actor effects are stronger for mothers and partner effects were only found for fathers. Implications for interventions are discussed.