bluuebunny/crossref_metadata_2025_split huggingface dataset:
DEPÓSITOS FLÚVIO-EÓLICOS DA FORMAÇÃO SÃO SEBASTIÃO, NA BORDA OESTE DA BACIA DE JATOBÁ, NORDESTE DO BRASIL
Authors: Veras José Diego Dias , Neumann Virginio Henrique de Miranda Lopes , Valença Lucia Maria Mafra , Cabral Flávia Araújo de Arruda , De Oliveira Silvio Roberto 
Published: January 2019

A Bacia de Jatobá, juntamente com a Sub-bacia de Tucano Norte, representam a extremidade setentrional do Sistema Rifte Recôncavo-Tucano-Jatobá, que possui direção geral N-S até a altura do Rio São Francisco, onde sofre uma inflexão para E-NE. Ao contrário das bacias da margem continental que evoluíram ao estágio de margem passiva, as Bacias Recôncavo, Tucano e Jatobá, constituem um ramo do Rifte Sul-Atlântico abortado no Eoaptiano. A Formação São Sebastião está inserida no estágio rifte da Bacia de Jatobá. Possui uma fácies fluvial que é composta por arenitos finos a grossos, por vezes conglomeráticos e, localmente, níveis seixosos. Os perfis estratigráficos realizados nesta fácies e a associação de fácies ressaltam suas características de composição e estruturas. A fácies eólica apresenta uma característica marcante como a sua bimodalidade no tamanho dos grãos de quartzo. Além disso, as estratificações cruzadas de alto ângulo corroboram a definição de ambiente eólico. São arenitos finos, às vezes médios, bem selecionados e variando de esbranquiçados a amarelados. Portanto, esta unidade é caracterizada como um sistema fluvial entrelaçado de alta energia que, posteriormente, passa por um retrabalhamento eólico
Estructuras musicales en la obra poética de José Ángel Valente: de Schenker a Guillaume de Machaut
Authors: Pastor Comín Juan José 
Published: January 2019

<p><span><span style="font-size: medium;">Los textos poéticos no constituyen entidades autorreferenciales limitadas a la propiedades de la palabra como signo lingüístico. Para José Ángel Valente, existe, más allá de la palabra, una estructura musical prelingüistica que contribuye a componer las reglas de interpretación de su obra literaria. Dichas claves musicales son imprescindibles para la comprensión extensa de los posibles sentidos comprendidos en sus versos y su consideración se impone como necesaria. En este trabajo veremos cómo la experiencia musical del poeta se convierte en instrumento decisivo para el ejercicio de la hermenéutica literaria. <span> </span></span></span></p>
Seasonal Activity of Adult Mosquitoes (Diptera: Culicidae) in a Focus of Dirofilariasis and West Nile Infection in Northern Iran
Authors: Azari-Hamidian Shahyad , Norouzi Behzad , Noorallahi Ayoob , Ali Hanafi-Bojd Ahmad 
Published: January 2019

Background: Mosquito-borne arboviruses such as West Nile, dengue, Rift Valley fever, and Sindbis viruses and the nematode Dirofilaria are reported in Iran, but there is little information on the seasonal activity of their vectors in the country. We aimed to determine the seasonal activity of adult mosquitoes (Diptera: Culicidae) in a focus of diro­filariasis and West Nile infection in Guilan Province, northern Iran.
Methods: Collections were carried out using light traps in seven counties at least two times from random sites and every two weeks from a fixed site (Pareh Village, Rudbar County) during Aug–Dec 2015 and Apr–Oct 2016.
Results: Overall, 16327 adult mosquitoes comprising 18 species representing seven genera were identified. The most prevalent species were Cx. theileri (23.59%), Cx. tritaeniorhynchus (20.75%), Cx. pipiens (19.37%), Ae. vexans (18.18%), An. pseudopictus (10.92%) and An. maculipennis s.l. (5.48%). Aedes pulcritarsis and Cx. perexiguus were found for the first time in Guilan Province. The active season of adult mosquitoes extended from early May to early Oct in the fixed site. There was no significant regression between the abundance of adult mosquitoes and the meteor­ological data during active season in the fixed site (P> 0.05, R2= 0.31).
Conclusion: Though no significant regression between the abundance of mosquitoes and the meteorological data was observed during active season, temperature and rice fields had a great influence in starting and ending active season in the region.
Nonoperative Treatment of Medial Ulnar Collateral Ligament Injuries in the Throwing Athlete
Authors: Kadri Omar M. , Okoroha Kelechi R. , Patel Ravi B. , Berguson Jon , Makhni Eric C. , Moutzouros Vasilios 
Published: January 2019

* Ulnar collateral ligament (UCL) injuries are common in overhead throwing athletes, particularly baseball players. Appropriate diagnosis, treatment, and rehabilitation are important in order for athletes to return to their preinjury condition.* Many patients, including the noncompetitive athletes and those with partial ligament tears, benefit from nonoperative treatment. Elite athletes desiring a return to play benefit from UCL reconstruction.* Rest, anti-inflammatory drugs, focused physical therapy, and biologic adjuncts are options that may allow athletes to return to play while avoiding the morbidity associated with operative treatment.
A formula for the settling velocity of cohesive sediment flocs in water
Authors: Zhu Zhongfan 
Published: January 2019

Abstract
A simple formula is developed to relate the size and settling velocity of cohesive sediment flocs in both the viscous and inertial settling ranges. This formula maintains the same basic structure as the existing formula but is amended to incorporate the fact that the flocculated sediment has an internal fractal architecture and is composed of different-sized primary particles. The input parameters needed for calculating the settling velocity include the median size and size distribution of the primary particles, the fractal dimension of the floc, the density of the sediment, and two calibrated coefficients that incorporate the effects of floc shape, permeability, and flow separation on drag. The proposed formula is compared with four data sets of settling velocity–floc size collected from the published literature, and a good agreement between the model and these data can be found.
Zoledronic Acid Inhibits the RhoA-mediated Amoeboid Motility of Prostate Cancer Cells
Authors: Pietrovito Laura , Comito Giuseppina , Parri Matteo , Giannoni Elisa , Chiarugi Paola , Taddei Maria Letizia 
Published: January 2019

Background:The bisphosphonate Zoledronic acid (ZA) is a potent osteoclast inhibitor currently used in the clinic to reduce osteoporosis and cancer-induced osteolysis. Moreover, ZA exerts an anti-tumor effect in several tumors. Despite this evidence, the relevance of ZA in prostate cancer (PCa) is not completely understood.Objective:To investigate the effect of ZA administration on the invasive properties of PC3 cells, which are characterised by RhoA-dependent amoeboid motility.Methods:The effect of ZA administration on the in vitro invasive properties of PC3 cells was evaluated by cell migration in 3D collagen matrices, immunofluorescence and Boyden assays or transendothelial migration. Lung retention and colonization assays were performed to assess the efficacy of ZA administration in vivo.Results:PC3 cells are characterised by RhoA-dependent amoeboid motility. We now report a clear inhibition of in vitro PC3 cell invasion and RhoA activity upon ZA treatment. Moreover, to confirm a specific role of ZA in the inhibition of amoeboid motility of PC3 cells, we demonstrate that ZA interferes only partially with PC3 cells showing a mesenchymal phenotype due to both treatment with conditioned medium of cancer associated fibroblasts or to the acquisition of chemoresistance. Furthermore, we demonstrate that ZA impairs adhesion to endothelial cells and the trans-endothelial cell migration, two essential properties characterising amoeboid motility and PC3 metastatic dissemination. In vivo experiments prove the ability of ZA to inhibit the metastatic process of PC3 cells as shown by the decrease in lung colonization.Conclusion:This study demonstrates that ZA inhibits Rho-dependent amoeboid motility of PC3 cells, thus suggesting ZA as a potential therapy to impede the metastatic dissemination of PC3 cells.
Bilateral Interrelationship of Diabetes and Periodontium
Authors: Badiger Apoorva B. , Gowda Triveni M. , Chandra Khyati , Mehta Dhoom S. 
Published: January 2019

:
Periodontitis is a chronic inflammatory disease characterised by destruction of the supporting
structures of the teeth which is a common cause of tooth mortality in all individuals throughout the
world. Diabetes is a group of metabolic dysregulation, primarily of carbohydrate metabolism, characterized
by hyperglycemia that results from defects in insulin secretion, impaired insulin action, or both.
Systematic reviews and meta-analysis have shown that the prevalence of periodontitis is increased in
diabetic patients. Based on the evidence, degree of hyperglycemia and severity of periodontitis are inter-
related. Diabetic patients with severe periodontitis have six times more poor glycemic control than
patients with healthy periodontium. However, improved glycemic control has been postulated to reduce
the severity of periodontal disease.

:
In this mini-review, we have presented the previously reviewed studies from the literature and focused
on a two-way relationship of diabetes and periodontitis, various pathways involved in it such as
RANK/RANKL/OPG axis, AGE-RAGE pathway, Oxidative stress mechanism, and obesity that influence
the possibility of periodontitis-Diabetes Mellitus (DM).
Nicotinamide Overcomes Doxorubicin Resistance of Breast Cancer Cells through Deregulating SIRT1/Akt Pathway
Authors: Wei Yingze , Guo Yan , Zhou Jianyun , Dai Kui , Xu Qiang , Jin Xiaoxia 
Published: January 2019

Background and Purpose:
Breast cancer is one of the leading causes of cancer deaths in female
worldwide. Doxorubicin represents the most common chemotherapy for breast cancer, whereas side effects and
development of resistance impede its effect on chemotherapy. Nicotinamide (NAM), serves as the sirtuins’
inhibitor, effectively suppressing various types of cancer. However, the effects of NAM on drug resistance of
breast cancer are need to be fully investigated.

Methods:
Breast cancer doxorubicin-resistant cells MCF-7/ADR and doxorubicin-sensitive cells MCF-7 were
applied in this study. Cell proliferation was assessed by CCK8 and colony-forming assays. Cell migration was
evaluated by scratch test and transwell assay while cell apoptosis was measured by TUNEL analysis. Expression
levels of SIRT1, phosphate Akt (P-Akt, Ser-473) and Akt were measured using western blot analysis. The interrelation
between SIRT1 and Akt was investigated by co-immunoprecipitation assay.

Results:
Treatment of nicotinamide combined with doxorubicin effectively inhibited cell growth, suppressed
cell migration, and promoted cell apoptosis of MCF7/ADR cells. Mechanistically, nicotinamide translocated
SIRT1 from the cell nucleus to cytoplasm, dissociated the connection between SIRT1 and Akt, and consequently
decreased expressions of SIRT1, and P-Akt, thereby inhibiting the growth of MCF7/ADR cells.

Conclusion:
Our results suggested that the value of nicotinamide is a potential therapeutic agent for breast
cancer treatment through downregulating SIRT1/Akt pathway, leading to the valid management of breast cancer
patients.
Effect of a novel succinamic acid derivative as potential anti-diabetic agent in experimental diabetic rats
Authors: Khurana Nikhil , Sharma Pankaj , Bhagat Sunita , Sharma Suman Bala 
Published: January 2019

4-((benzyloxy) amino)-2-hydroxy-4-oxobutanoic acid which is a succinamic acid derivative has been synthesized in 3 step reaction with malic acid. Its structure confirmation was done by various techniques like 1H NMR, 13C NMR, & HRMS and is recently proposed as an insulinotropic agent for the treatment of non-insulin dependent diabetes mellitus. In the present study, the effect of 4-((benzyloxy) amino)-2-hydroxy-4-oxobutanoic acid on plasma glucose, serum insulin, serum lipid profile and lipid peroxidation in streptozotocin–nicotinamide induced type 2 diabetic model was investigated. 4-((benzyloxy) amino)-2-hydroxy-4-oxobutanoic acid was administered orally (20 mg/kg b.w.) to streptozotocin + nicotinamide (STZ + NAD) induced diabetic rats for 28 days. A significant increase in fasting blood glucose levels, HbA1c levels, Serum lipid profile (TG & TC) and in the levels of Malonaldialdehyde (MDA, end product of lipid peroxidation) was observed in STZ +NAD diabetic rats whereas the levels of high density lipoprotein-cholesterol (HDL-C) and serum insulin levels were significantly decreased in STZ + NAD induced diabetic rats The effect of 4-((benzyloxy)amino)-2-hydroxy-4-oxobutanoic acid was compared with glibenclamide, a reference drug. Treatment with 4-((benzyloxy) amino)-2-hydroxy-4-oxobutanoic acid and glibenclamide resulted in a significant reduction of fasting blood glucose levels with increase in plasma insulin levels in diabetic treated rats. 4-((benzyloxy) amino)-2-hydroxy-4-oxobutanoic acid also resulted in a significant improvement in serum lipids and lipid peroxidation products. Our results suggest the potential role of 4-((benzyloxy) amino)-2-hydroxy-4-oxobutanoic acid in the management of type-2 diabetes mellitus experimental rats.
Keywords: 4-((benzyloxy) amino)-2-hydroxy-4-oxobutanoic acid, dyslipidemia, streptozotocin induced diabetes, lipid peroxidation
Extraction of Momordica charantia, Pongamia glabra and Piper nigrum: Qualitative and Quantitative assessment
Authors: Shukla Rashmi , Kashaw Varsha 
Published: January 2019

Objective: The objective of present work was to evaluate the qualitative and quantitative assessment of momordica charantia, pongamia glabra and piper nigrum extract for the natural product present in them. These plants were having the rich source of alkaloid, glycoside, tannins, carbohydrates, saponins, flavonoids, proteins and amino acids and were used as anti-diabetic, anti-inflammatory, antitumor, anti-malarial and having wound healing potential. Materials and Methods: Extract of all three plants has been separated by the process of Soxhlet extraction. The extract of momordica charantia, pongamia glabra and piper nigrum evaluated for qualitative and quantitative measurement of alkaloid, glycoside, tannins, carbohydrates, saponins, flavonoids, proteins and amino acids content. Different solvent is used for the extraction of content includes petroleum ether, ethyl acetate, alcoholic and distilled water. Results and Conclusion: Preliminary Phytochemical screening was performed for extracts of Momordica charantia fruits (FMC), Pongamia glabra (LPG) and Piper nigrum fruits (FPN). Identification test on extracts was shown the sign of alkaloid, glycoside, tannins, carbohydrates, saponins, flavonoids, proteins and amino acids content. Discussion: All results indicates that extracts of Momordica charantia fruits (FMC), Pongamia glabra (LPG) and Piper nigrum fruits (FPN) having a rich source of Glycosides, alkaloid and flavonoid content.
Keywords: momordica charantia, pongamia glabra, piper nigrum, glycosides, flavonoid, extraction.
Anti-bacterial activity, anti-cancer activity and nanofiber formation of certain poly (ester amides) from 2,5-pyridine dicarboxylic acid
Authors: Chitra V. , Singh D. Roop 
Published: January 2019

A new series of four poly(ester amides) were synthesized by direct polycondensation of 2,5-pyridine dicarboxylic acid with two different varying diols and diamines in pyridine medium using diphenylchlorophosphate as a condensation agent. The two diamines employed in the synthesis were 4,4’-diamino diphenyl methane and 1,4-diamino benzene. The arylidenediols 2,5-bis(4-hydroxy-3-methoxybenzylidene)cyclopentanone and 2,6-bis(4-hydroxy-3-methoxybenzylidene) cyclohexanone were also used. The synthesized poly(ester amides) were characterized by qualitative solubility test, FT-IR, 1H and 13C-NMR spectra. The monomeric moieties were found by spectroscopic analysis to be well incorporated in the polymer back bone. The thermal phase transition behavior of the poly(ester amides) were investigated by differential thermo gravimetry (DTG). The nanofibers of synthesized poly(ester amides) with PVC and composite fibers with PVC/nanoclay were formed by electrospinning. The morphology of these composite fibers was studied by scanning electron microscopy (SEM). These poly(ester amides) were screened for their anti-bacterial potential in vitro against Pseudomonas aeruginosa, Escherichia coli, Staphylococcus aureus and Bacillus subtilis. In vitro anti-cancer activities of synthesized polymers were also evaluated against MCF7 human breast carcinoma cells. The results show that the polymers exhibited significant anti-bacterial and anti-cancer activity.
Keywords: Poly (ester amides), Anti-bacterial activity, Nano fiber, Anticancer activity
Study of the hyperglycemic condition in diseases of liver in obese clinical patients
Authors: Singh Chander Jeet , Kumar Dinesh 
Published: January 2019

Hyperglycemia is best documented by Whipple´s triad: symptoms compatible with hypoglycemia, low blood glucose concentration and alleviation of symptoms after the glucose concentration is raised. In experimental studies in healthy adults, the threshold for symptoms of hyperglycemia is on average a blood glucose level of 3.0 mmol/l Mitrakou reported autonomic symptoms of hyperglycemia to begin at a blood glucose level of 3.2 mmol/l, and deterioration in cognitive function tests at a level of 2.7 mmo/l. When sensory evoked potentials were measured in relation to blood glucose concentrations in infants and children with episodes of hyperglycemia, abnormalities were noted at blood glucose levels less than 2.6 mmol/l.
Keywords: Hypertension, Diabetes mellitus, Glucose, Glycolysis.
Antioxidants: a brief review
Authors: Bisht Rekha 
Published: January 2019

The field of free radical chemistry has gained a great deal of attention in recent years. Free radicals reactive oxygen species generated by our body by various endogenous systems leads to various pathological conditions. A balance between free radicals and antioxidants is prerequisite for proper physiological function. Oxidative stress caused by generation of free radicals adversely alters lipids, proteins, and DNA and provokes a number of human ailments. Oxidative stress can be managed by using external sources of antioxidants. Synthetic antioxidants such as butylated hydroxytoluene and butylated hydroxyanisole have recently been reported to be harmful for human health. Thus, the search for effective, nontoxic natural compounds with antioxidant activity has been escalated in recent years. The present review provides a brief overview on antioxidants and natural sources of antioxidants in the management of human diseases.
Keywords: free radical, Oxidative stress, antioxidants,
Comparative Evaluation of Two Different Marketed Brands of Enalapril maleate
Authors: Kumar Manish , Tyagi Shahnwaj , Bhatt Shailendra , Pandurangan A. , Saini Vipin , Malik Anuj , Alam Md Shamshir 
Published: January 2019

Efficacy of pharmaceuticals dosage form generally depends on their formulation properties and manufacturing methods, hence it is likely that the quality of dosage form may vary. Renin acts on angiotensinogen to form angiotensin I, which is converted to angiotensin II by angiotensin-converting enzyme (ACE). Angiotensin II, a potent vasoconstrictor increases blood pressure by increasing vasopressin production and aldosterone secretion. Enalaprilat, the active metabolite of enalapril, inhibits ACE, hence decreases levels of angiotensin II resulting in less vasoconstriction and decreased blood pressure. The study was exclusively experimental that used IP and other standard books to check in vitro quality of enalapril maleate tablet using different analytical techniques and procedure. Test for weight variation, hardness, friability, disintegration time, and dissolution were conducted. The dissolution test was performed at pH 6.8 for both the brands of the tablet. Further all the tablets passed weight variation, hardness, friability and disintegration test as per the pharmacopoeial standard. Hence we can conclude that both the brands of tablets are equal and both the brands contain equal quantity of active pharmaceutical ingredient (API). Both the brands having higher and lower costs exert similar action.
Keywords: Enalapril maleate, In Vitro, Dissolution test, Enalapril
Anticancer (liver cancer cell lines) and antioxidant activity of Cassia auriculata flower extract from acetone and methanol solvents
Authors: Padmalochana K 
Published: January 2019

This research paper was communicated to elucidate the antioxidant and anticancer activities of acetone and methanol extract of Cassia auriculata flower. Antioxidant activity was assessed against DPPH and hydroxyl free radical. The anticancer activity was examined by inhibition on liver cancer cell lines. The highest antioxidant activity was found for methanol extract (IC50: 46.28 μg/ml) than acetone extract (IC50: 52.60 μg/ml) on DPPH free radical. The IC50 values for methanol and acetone extract was found to be 47.05 and 56.01±1.85 µg/ml, respectively on hydroxyl radical. The highest anticancer activity was found for methanol extract to be 36.10±2.46 µg/ml. Among these extract methanol extract have high antioxidant and anticancer activity.
Keywords: Antioxidant, anticancer, Plant
Therapeutical and medicinal properties of Neem (Azadirachta indica) in context of Unani system of medicine: a review study
Authors: Quraishi Haider Ali , Islam Naquibul , Iqbal Arsheed , Bhat Shabir Ahmad , Ahmed Jameel , Ashraf Syed Sabahat , Khan Qamar Alam 
Published: January 2019

Neem is very important medicinal plant which is used to treat different diseases in Unani System of Medicine as well as traditional system of medicine (Ayurveda, Homeopathic Chines and European “Materia Medica”). The use of traditional medicine and medicinal plants in most developing countries, as a normative basis for the maintenance of good health, has been widely observed. In the last century, approximately 130 pharmaceutical products have been discovered based on the information obtained from the traditional scientist and physician. The importance of the neem tree has been recognized by the US National Academy of Sciences, which publish a report in 1992 entiteled ‘Neem- a tree for solving global problems’. The scientific name of neem, Azadirachta indica, is derived from the Persian, Azad means “Free” dirakht means “tree” I-Hindi means “of Indian Origin” .Hence it literally means “the free tree of India”. The Chemical principles from natural sources have become much simpler and have contributed significantly to the development of new drugs from medicinal plants and because of these facts the domain market for plant derived chemicals, pharmaceuticals, fragrances, flavor’s, and color ingredients, alone exceeds several billion dollars per year. The present review highlights a Unani medicine literature as well as scientific on taxonomical, botanical, and pharmacological discussion on Neem.
Keywords: Neem, Azadirachta indica, Unani Medicine, Nim.