bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect Size Benchmarks for Response Elaboration Training: A Meta-Analysis
Authors: Bunker Lisa D. , Nessler Christina , Wambaugh Julie L. 
Published: July 2018

Purpose
With a number of single-case experimental design studies reporting the effects of treatment for response (and modified response) elaboration training (RET/M-RET), it is important to consolidate data over multiple participants to allow comparison within/between individuals and across similar treatments. The purpose of this study was to conduct a meta-analysis of single-case experimental design studies of RET/M-RET and to determine effect size (ES) benchmarks to allow comparison to “group” data.

Method
Database and bibliographical searches identified 20 investigations of RET/M-RET. Nine studies had sufficient experimental quality, compliance with the essential components of the RET protocol, and consistency in the dependent variable (i.e., accurate content production in response to picture stimuli) to be retained for the meta-analysis. Probe data for a total of 26 persons with aphasia (PWA) were extracted from published graphs (if raw data were not available) to calculate weighted ESs at the end of treatment and at follow-up for both treated and untreated stimuli. The first, second, and third quartiles of the distributions were used to serve at benchmarks for small, medium, and large effects.

Results
Nearly all participants demonstrated positive effects as a result of RET/M-RET, indicating an association with positive changes in content production for PWA. Small, medium, and large benchmarks are reported for treated items after treatment and at follow-up, as well as for untreated items after treatment and at follow-up.

Conclusions
With a larger sample of 26 participants, this analysis indicates that RET/M-RET are associated with positive changes in content production for PWA. ES benchmarks allow clinicians/researchers to compare an individual's performance across multiple applications of treatment to performance of other PWA and to other treatments with similar outcomes.
Interactive Storybook Reading Instruction for Preschoolers Who Are Deaf and Hard of Hearing: A Multiple Probe Across Behaviors Analysis
Authors: Trussell Jessica W. , Hasko Janna , Kane Joy , Amari Brittany , Brusehaber Alison 
Published: July 2018

Purpose
Interactive storybook reading (ISR) improves the picture labeling vocabulary of children who are deaf and hard of hearing (DHH). Vocabulary knowledge consistently predicts the later reading achievement of children who are DHH. In this study, ISR was modified to include teaching word meanings along with the vocabulary picture label.

Method
A multiple probe across behaviors single-case experimental design was implemented to determine the effects of ISR with word meaning instruction on picture labeling and word meaning knowledge of 6 preschoolers who are DHH and use spoken English. The student and teacher participants engaged in ISR for 15–20 min a day, 4 days a week for 3 weeks.

Results
A functional relation was established between ISR and the increase in the preschoolers' word labeling and meaning knowledge. The preschoolers' word knowledge was generalized and was maintained over time.

Conclusions
ISR may be an effective vocabulary labeling and word meaning instructional strategy for young children who are DHH and use spoken English. Teachers and related service providers who work with this population may want to implement ISR with word meaning in 1-to-1 or small groups to individualize the target vocabulary and maximize the benefit. Future researchers should replicate this to expand its generalizability to other subpopulations of children who are DHH.
Deciphering the oscillation spectrum of γ Doradus and SPB stars
Authors: Christophe S. , Ballot J. , Ouazzani R.-M. , Antoci V. , Salmon S. J. A. J. 
Published: July 2018

Context. The space-based Kepler mission provided four years of highly precise and almost uninterrupted photometry for hundreds of γ Doradus stars and tens of slowly pulsating B-type (SPB) stars, finally allowing us to apply asteroseismology to these gravity mode pulsators. Without rotation, gravity modes are equally spaced in period. This simple structure does not hold in rotating stars for which rotation needs to be taken into account to accurately interpret the oscillation spectrum.
Aims. We aim to develop a stellar-model-independent method to analyse and interpret the oscillation spectrum of γ Dor and SPB stars.
Methods. Within the traditional approximation of rotation, we highlight the possibility of recovering the equidistance of period spacings by stretching the pulsation periods. The stretching function depends on the degree and azimuthal order of gravity modes and the rotation rate of the star. In this new stretched space, the pulsation modes are regularly spaced by the stellar buoyancy radius.
Results. On the basis of this property, we implemented a method to search for these new regularities and simultaneously infer the rotation frequency and buoyancy radius. Tests on synthetic spectra computed with a non-perturbative approach show that we can retrieve these two parameters with reasonable accuracy along with the mode identification. In uniformly rotating models of a typical γ Dor star, and for the most observed prograde dipole modes, we show that the accuracy on the derived parameters is better than 5% on both the internal rotation rate and the buoyancy radius. Finally, we apply the method to two stars of the Kepler field, a γ Dor and an SPB, and compare our results with those of other existing methods.
Conclusions. We provide a stellar-model-independent method to obtain the near-core rotation rate, the buoyancy radius, and the mode identification from gravity-mode spectra of γ Dor and SPB stars.
Gaia Data Release 2
Authors: Mowlavi N. , Lecoeur-Taïbi I. , Lebzelter T. , Rimoldini L. , Lorenz D. , Audard M. , De Ridder J. , Eyer L. , Guy L. P. , Holl B. , Jevardat de Fombelle G. , Marchal O. , Nienartowicz K. , Regibo S. , Roelens M. , Sarro L. M. 
Published: July 2018

Context. Gaia Data Release 2 (DR2) provides a unique all-sky catalogue of 550 737 variable stars, of which 151 761 are long-period variable (LPV) candidates with G variability amplitudes larger than 0.2 mag (5–95% quantile range). About one-fifth of the LPV candidates are Mira candidates, the majority of the rest are semi-regular variable candidates. For each source, G, GBP, and GRP photometric time-series are published, together with some LPV-specific attributes for the subset of 89 617 candidates with periods in G longer than 60 days.
Aims. We describe this first Gaia catalogue of LPV candidates, give an overview of its content, and present various validation checks.
Methods. Various samples of LPVs were used to validate the catalogue: a sample of well-studied very bright LPVs with light curves from the American Association of Variable Star Observers that are partly contemporaneous with Gaia light curves, a sample of Gaia LPV candidates with good parallaxes, the All-Sky Automated Survey for Supernovae catalogue of LPVs, and the Optical Gravitational Lensing Experiment (OGLE) catalogues of LPVs towards the Magellanic Clouds and the Galactic bulge.
Results. The analyses of these samples show a good agreement between Gaia DR2 and literature periods. The same is globally true for bolometric corrections of M-type stars. The main contaminant of our DR2 catalogue comes from young stellar objects (YSOs) in the solar vicinity (within ~1 kpc), although their number in the whole catalogue is only at the percent level. A cautionary note is provided about parallax-dependent LPV attributes published in the catalogue.
Conclusions. This first Gaia catalogue of LPVs approximately doubles the number of known LPVs with amplitudes larger than 0.2 mag, despite the conservative candidate selection criteria that prioritise low contamination over high completeness, and despite the limited DR2 time coverage compared to the long periods characteristic of LPVs. It also contains a small set of YSO candidates, which offers the serendipitous opportunity to study these objects at an early stage of the Gaia data releases.
Massive Blutung aus infiziertem Punktionskanal
Authors: Krönung Gerhard 
Published: July 2018

ZusammenfassungEinzeitige autologe In-situ-Infektsanierungen sind in der Gefäßchirurgie nicht Standard. Der Erfahrene kann mit Einsatz dieser Methode aufwendigere Revisionen (z. B. extraanatomischer Bypass) oder komplikationsträchtige Alternativen (E-PTFE-Shunts, zentralvenöse Katheter) vermeiden.
Spondylitis – Spondylodiscitis – an Update
Authors: Bornemann Rahel , Rössler Philip , Jacobs Cornelius , Randau Thomas , Rommelspacher Yorck , Wirtz Dieter , Pflugmacher Robert 
Published: July 2018

ZusammenfassungDie Spondylodiszitis ist eine Infektion der Bandscheiben mit einer nachfolgenden Infektion der benachbarten Wirbelkörper. Hauptursache sind 3 Erregergruppen: Bakterien (pyogene Infektion), Tuberkuloseerreger und Pilze (granulomatöse Infektion) und Parasiten. Bei der pyogenen Spondylodiszitis dominieren meist Monoinfektionen mit Staphylococcus aureus bei einer Häufigkeit bis zu 80%. Die Letalität liegt bei der Spondylodiszitis bei 2 – 3%. Tuberkulöse Infektionen sind häufig mit Psoas- und paravertebralen Abszessen assoziiert. In bis zu 50% der Patienten werden neurologische Ausfälle registriert. Zur mikrobiologischen Diagnostik werden Blutkulturen für aerobe und anaerobe Keime eingesetzt. Die histologische Untersuchung führt jedoch signifikant häufiger zu einem positiven Erregernachweis. Hinsichtlich Genauigkeit ergibt sich eine deutliche Überlegenheit der 16S-rRNA-PCR im Vergleich zur mikrobiologischen Untersuchung von Gewebeproben. Das MRT zeigt eine hohe Sensitivität und Spezifität und ist daher den anderen radiologischen Methoden überlegen. Die Beseitigung der Infektion, die Verminderung der schmerzhaften Beschwerden sowie die Wiederherstellung und Bewahrung von Struktur bzw. Funktion der Wirbelsäule gelten als Hauptziele jeder Behandlungsmaßnahme. Eine standardisierte Antibiotikatherapie der Spondylodiszitis ist bisher nicht eindeutig definiert. Entscheidend sind der Erregernachweis und eine entsprechende gezielte Antibiotikatherapie. Die antibiotische Therapie sollte zunächst 2 – 4 Wochen intravenös verabreicht werden. Anschließend ist eine Umstellung auf eine orale Gabe für 6 – 12 Wochen vorzusehen. Beim Nachweis antibiotikaresistenter Infektionen mit neurologischen Ausfällen wird empfohlen, ein chirurgisches Vorgehen mit sorgfältigem Débridement und Instrumentation vorzunehmen sowie eine Nachbehandlung mit intravenös verabreichten Antibiotika über 3 Wochen mit anschließend 3-monatiger oraler Antibiotikabehandlung zu verordnen. Chirurgische Eingriffe sind indiziert bei neurologischen Defiziten, progressiver Zunahme spinaler Deformierungen, Versagen der konservativen Therapie mit unzureichender Schmerzlinderung und unsicherer Keimidentifizierung. Die Auswahl des Operationsverfahrens sollte hauptsächlich nach dem Ausmaß der Knochendestruktion, der Lokalisation und den individuellen Gegebenheiten bei den Patienten richten. Eine gute Prognose kann gestellt werden, wenn CRP und BSG in den ersten Wochen deutlich abfallen.
Telemedizin in der Nephrologie
Authors: Jahn Michael , Kopecky Jens , Meister Sven , Kribben Andreas , Koisar Karoline , Becker Stefan 
Published: July 2018

ZusammenfassungInnovative Ansätze in der Telemedizin haben das Potenzial, die Versorgung von Patienten in der Nephrologie effizienter und effektiver zu gestalten. Zum Einsatz
kommende Systeme sollten unabhängig von technischen Spezifizierungen Daten untereinander austauschen können und im Einklang mit Datenschutzvorgaben und der
ärztlichen Schweigepflicht sein.
Vermindertes Wachstum bei nierenkranken Kindern
Authors: Hartmann Lisa Maria 
Published: July 2018

ZusammenfassungEine chronische Niereninsuffizienz bedeutet für betroffene Kinder eine nicht unerhebliche Veränderung in ihrem jungen Leben – Dialysesitzungen, eine Umstellung ihrer Ernährung, die Einnahme von Medikamenten und schließlich auch einverzögertes Längenwachstum. Verschiedene, durch die Niereninsuffizienz bedingte Pathomechanismen verhindern, dass das vom Körper ausreichend produzierte Wachstumshormon an entsprechenden Stellen in richtiger Dosierung adäquat wirken kann. An dieser Stelle kann betroffenen Kindern eine Therapie mit dem Wachstumshormon helfen, das täglich über eine subkutane Injektion verabreicht wird. Diese Therapieoption bedeutet jedoch nicht nur Positives für die kleinen Patienten und deren Familien, sodass eine Therapieentscheidung mit allen Möglichkeiten, Risiken und Begleittherapien (Ernährungstherapie, medikamentöse Therapie des Säure-Basen-Haushaltes u. a.) zusammen mit den Familien getroffen werden muss.
An Unusual Case of Acute Thrombosis of Abdominal Aortic Aneurysm without Acute Limb Ischemia
Authors: Vasdekis Spyridon , Mastoraki Sotiria , Lazaris Andreas , Moulakakis Konstantinos 
Published: July 2018

AbstractAcute thrombosis of an abdominal aortic aneurysm (AAA) is a rare and often devastating complication with high morbidity and mortality. In some cases, however, it may be associated with a silent course without signs of acute limb ischemia. The aim of this report is to describe an unusual case of acute thrombosis of AAA without signs of acute limb ischemia. Preoperative anxiety, stress, and phobia for surgery may be factors predisposing to acute thrombosis of an AAA.
Genes Associated with Thoracic Aortic Aneurysm and Dissection: 2018 Update and Clinical Implications
Authors: Brownstein Adam , Kostiuk Valentyna , Ziganshin Bulat , Zafar Mohammad , Kuivaniemi Helena , Body Simon , Bale Allen , Elefteriades John 
Published: July 2018

AbstractThoracic aortic aneurysms, with an estimated prevalence in the general population of 1%, are potentially lethal, via rupture or dissection. Over the prior two decades, there has been an exponential increase in our understanding of the genetics of thoracic aortic aneurysm and/or dissection (TAAD). To date, 30 genes have been shown to be associated with the development of TAAD and ∼30% of individuals with nonsyndromic familial TAAD have a pathogenic mutation in one of these genes. This review represents the authors' yearly update summarizing the genes associated with TAAD, including implications for the surgical treatment of TAAD. Molecular genetics will continue to revolutionize the approach to patients afflicted with this devastating disease, permitting the application of genetically personalized aortic care.
Hemi-Cabrol Aortic Root Replacement in Complex Aortic Reconstructions
Authors: Dimarakis Ioannis , Kadir Isaac 
Published: July 2018

AbstractThe Cabrol aortic root replacement with subsequent modifications remains an extremely useful technique within the armamentarium of the aortic surgeon. The technical considerations detailed here allow for the uncompromised creation of a hemi-Cabrol anastomosis in complex aortic reconstructions.
Plasma and Platelet Lipid Composition and Platelet Aggregation by Arachidonic Acid in Women on the Pill
Authors: Sadurska B , Tacconi M T , di Minno G , Roncaglioni M C , Pangrazzi J , Donati M B , Bizzi A , Silver M J 
Published: July 2018

SummarySensitivity to induction of platelet aggregation by arachidonic acid (AA) and changes in plasma and platelet polyunsaturated fatty acid distribution were studied in seven women before and after six months of oral contraceptive (OC) treatment with a combination of d-norgestrel (0.25 mg) and ethinylestradiol (0.05 mg). Special interest was focused on AA because certain metabolites of this fatty acid induce platelets to aggregate and are considered to play a crucial role in thromboembolic processes.In plasma, AA concentrations increased slightly, but significantly, in both the free fatty acid (FFA) and phospholipid fractions; in platelets AA increased in the phospholipid and neutral lipid fractions. The threshold aggregating concentration (TAC) of AA was significantly reduced in platelets of women after six months of OC treatment (0.65 ± 0.08 versus 0.30 ±0.04 mM). This suggests that changes in platelet fatty acid composition may be associated with in vitro changes in platelet sensitivity to AA. Such changes may contribute to the thrombotic tendency associated with OC treatment.
A Survey of 215 Non-Hemophilic Patients with Inhibitors to Factor VIII
Authors: Green David , Lechner Klaus 
Published: July 2018

SummaryInformation was obtained by questionnaire about 215 nonhemophilic patients who developed inhibitors against factor VIII (antihemophilic factor). The majority of the patients were over 50 years of age, and approximately equal numbers of males and females were reported. Rheumatoid arthritis was present in 8% of the cases, 7% occurred during pregnancy or the post-partum period, and in several there was an association with allergy to penicillin, asthma, “auto-immune” diseases, or malignancy. In 46% of cases, no underlying disorders were identified. Major bleeding was observed in 87 % of patients, and in 22%, death was attributed either directly or indirectly to the presence of the inhibitor.In 11 of 31 patients receiving no therapy other than supportive transfusions of blood or factor VIII concentrate, the inhibitor disappeared after being present for an average duration of 14 months. Corticosteriods were thought to be effective in abolishing the inhibitor in 22 of 45 patients in whom these were the only drugs administered. Twenty-eight patients received azathioprine as well as corticosteriods; in 19, the inhibitor declined or disappeared during treatment. Finally, 80 patients were treated with cyclophosphamide; in 37 there was a favorable outcome. Inhibitors in children and post-partum patients were more likely to disappear spontaneously or with steroid therapy, whereas those in patients with rheumatoid arthritis or other “autoimmune” disorders required treatment with alkylating agents. However, before any specific therapy can be recommended for this disorder, prospective trials of potential therapeutic agents should be conducted in selected subgroups.
A Novel Missense Mutation in Two Families with Congenital Plasminogen Deficiency: Identification of an Ala675 to Thr675 Substitution
Authors: Mima N , Azuma H , Shigekiyo T , Saito S 
Published: July 2018

SummaryWe used a polymerase chain reaction (PCR) strategy and restriction fragment polymorphism analysis to evaluate all 19 exons of the plasminogen (PLG) gene in a Japanese patient with congenital PLG deficiency and her family members (family C). Sequence analysis following amplification of each exon and its flanking regions showed a single G to A transition in exon 17, resulting in the conversion of an Ala675 codon (GCT) to Thr675 codon (ACT). Since this mutation generates a new Mae III site, the Mae III digestion patterns of the PCR-amplified exon 17 fragments from each family member were analyzed. In all cases, the patterns correlated with the activities and antigen levels of plasma PLG in those members. The identical G to A transition in the same codon of exon 17 was detected by a Mae III digestion experiment in another proband and her family members with congenital PLG deficiency (family K). Furthermore, 20 normal individuals examined had no Mae III restriction site at this location. We conclude that a G to A transition in exon 17 is responsible for the congenital PLG deficiency inherited in these two Japanese families.
Probability of Recurrence of Thrombosis in Patients with and without Factor V Leiden
Authors: Rintelen C , Pabinger I , Knöbl P , Lechner K , Mannhatter Ch 
Published: July 2018

SummaryActivated protein C (APC) resistance is a common risk factor for venous thromboembolism and is associated with the replacement of Arg 506 by Gin in the factor V gene (factor V Leiden). We investigated the risk of recurrence of venous thromboembolism in APC resistant patients heterozygous and homozygous for FV Leiden and compared these patient groups with a group of patients, who had a history of venous thromboembolism, but had neither APC resistance nor the FV Leiden mutation. APC resistance was determined in frozen blood samples from patients with a history of venous thromboembolism, who were not receiving oral anticoagulant (OAC) treatment. The plasma samples were collected between 1984 and 1991. Twenty-one patients in whom APC resistance was found in the stored plasma samples were reinvestigated in 1994 (5 males, 16 females, median [m] age 49 years, range 21-71 years). Twenty-one sex and age matched patients with venous thromboembolism (5 males, 16 females, age m = 50 years, range 25-73 years) investigated during the same time period who had a normal APC resistance test served as a control group. Patients with APC resistance as well as controls were reinvestigated for the presence of FV Leiden by genetic analysis in 1994. Of the 21 APC resistant patients, 5 were homozygous and 16 heterozygous for FV Leiden. Before the study entry homozygous patients had a significantly higher recurrence rate (5/5 patients) compared to the control group, in heterozygous patients (9/16) and controls (9/21) the recurrence rate was not significantly different.The total observation time was 21 years in patients with homozygous FV Leiden, 83 years in patients with heterozygous FV Leiden and 108 years in controls, excluding the time when patients were on OAC treatment. During the observation time the recurrence rate was highest in patients with homozygous FV Leiden (9.5 % per patient per year), but was similar in patients with heterozygous FV Leiden (4.8% per patient per year) and controls (5% per patient per year). Two of five (40%) homozygous patients, 4/16 (25%) heterozygous and 5/21 (24%) controls had at least one recurrent event during the observation period. The probability for development of thrombosis in the Kaplan-Meyer-Plot analysis was not different between the three groups.Bearing limitations of our study in mind (retrospective design, relatively small patient number) we conclude that the risk of recurrence after a thromboembolic event is not higher in patients with heterozygous FV Leiden than in patients without this mutation. Thus, it appears that the identification of heterozygous FV Leiden mutation is not an indication for long-term OAC treatment. Also, long-term OAC treatment cannot generally be recommended for homozygous patients with a single thromboembolic event. More definitive conclusions will require larger prospective studies.
Aprotinin in Aortocoronary Bypass Surgery: Increased Risk of Vein-Graft Occlusion and Myocardial Infarction? Supportive Evidence from a Retrospective Study
Authors: van der Meer J , Hillege H L , Ascoop C A P L , Dunselman P H J M , Mulder B J M , van Ormmen G V A , Pfisterer M , van Gilst W H , Lie K I ,   For the CABADAS Research Group of the Interuniversity Cardiology institute of the Netherlands
Published: July 2018

SummaryTo assess the thrombotic risk of aprotinin in aortocoronary bypass surgery, we retrospectively analyzed the results of a trial, originally designed to compare the effects of one-year treatment with various antithrombotic drugs in the prevention of vein-graft occlusion. Graft patency at one year was assessed by angiography. Myocardial infarction, thromboembolism, major bleeding, and death were clinical endpoints. Of 948 randomized patients, 42 received aprotinin, all enrolled by one of the participating centres. Occlusion rates of distal anastomoses were 20.5% in the aprotinin group and 12.7% in the non-aprotinin group (p = 0.091). The proportions of patients with occluded grafts were 44.1% versus 26.3% (p = 0.029). Perioperative myocardial infarction occurred in 14.3% and 7.0%, respectively (p = 0.12). Mean postoperative blood loss was 451 ml in the aprotinin group compared with 1039 ml in the non-aprotinin group (p <0.0001). Mean transfusion requirements were 1.1 U versus 2.1 U of red blood cells (p = 0.004).Aprotinin decreases blood loss and transfusion requirement. Our data suggest that this benefit may be associated with a reduction of graft patency and an increased risk of myocardial infarction.