bluuebunny/crossref_metadata_2025_split huggingface dataset:
Structural-Controlled Synthesis of Highly Efficient Visible Light TiO2 Photocatalyst via One-Step Single-Mode Microwave Assisted Reaction
Authors: Kato Kunihiko , Xin Yunzi , Shirai Takashi 
Published: March 2019

AbstractTiO2 with different chemical structures are successfully synthesized via a one-step single-mode magnetic microwave (SMMW) assisted process, during where Ti selectively oxidizes in magnetic field under Ar-O2 mixed atmosphere. The chemical state and band structure of the as-prepared TiO2 are well-controlled by changing the volume fraction of O2 (φO2) during SMMW synthesis. Ti3+ self-doped TiO2 (TiO2−x, 0 < x < 2) is synthesized under lower φO2, while TiO2 with specific core/shell structure (TiO2+y core/TiO2−x-TiO2+z shell) is observed under higher φO2. The as-synthesized TiO2 with controlled structures show sufficient light absorption in visible region and quite narrow bandgap (2.05 eV∼), whose value can be also tuned by φO2 during SMMW synthesis. In addition, the synthesized TiO2 exhibits highly efficient photocatalytic performance towards the degradation of Rhodamine B under UV and visible light irradiation. The formation mechanism for different structural TiO2 can be attributed to the specific rapid heating and cooling dynamics induced by SMMW irradiation.
Comprehensive Experimental System for a Promising Model Organism Candidate for Marine Teleosts
Authors: Sakaguchi Keishi , Yoneda Michio , Sakai Noriyoshi , Nakashima Kanako , Kitano Hajime , Matsuyama Michiya 
Published: March 2019

AbstractA comprehensive experimental system for Japanese anchovy, a promising candidate model organism for marine teleosts, was established. Through the design of a rearing/spawning facility that controls the photoperiod and water temperature, one-cell eggs were continuously obtained shortly after spawning throughout the rearing period. The stages of eggs are indispensable for microinjection experiments, and we developed an efficient and robust microinjection system for the Japanese anchovy. Embryos injected with GFP mRNA showed strong whole-body GFP fluorescence and the survival rates of injected- and non-injected embryos were not significantly different, 87.5% (28 in 32 embryos) and 90.0% (45 in 50 embryos), respectively. We verified that the Tol2 transposon system, which mediates gene transfer in vertebrates, worked efficiently in the Japanese anchovy using the transient transgenesis protocol, with GFP or DsRed as the reporter gene. Finally, we confirmed that genome-editing technologies, namely Transcription Activator-Like Effector Nucleases (TALEN) and Clustered Regulatory Interspaced Short Palindromic Repeats (CRISPR)/Cas9, were applicable to the Japanese anchovy. In practice, specific gene-disrupted fishes were generated in the F1 generation. These results demonstrated the establishment of a basic, yet comprehensive, experimental system, which could be employed to undertake experiments using the Japanese anchovy as a model organism for marine teleost fish.
Nerve electrical stimulation enhances osseointegration of implants in the beagle
Authors: Zhou Ping , He Fei , Liu Bin , Wei Shicheng 
Published: March 2019

AbstractDental implantation has been the primary method for the treatment of tooth loss, but longer than 3 months healing times are generally required. Because immediate load implants are suitable only for certain categories of implant patients, it has value to develop a novel method to facilitate the implant-bone osseointegration process. Cylindrical titanium implants were implanted in the tooth sockets of beagles, and microelectrode stimulation of the sympathetic nerves in the infraorbital nerve was performed after implantation for 1 week. The authors found that one-sided nerve stimulation was shown to evoke consistent electric potential changes in both sides of the infraorbital nerves. Moreover, after 4 weeks of implantation, more new bone was clearly observed around the implants in the beagles that received electrical stimulation treatment than was observed in the control animals. Furthermore, a higher mineralization density was measured in the new peri-implant bone tissues of the stimulated beagles when compared to controls. These results demonstrate that the simple and safe physical method of microelectrode stimulation to sympathetic nerves can promote the formation of new bone and the osseointegration of implants. This technique is worth promoting and has the potential to reduce the healing time of dental implantation in future clinical cases.
Genetic divergence of native palms of Oenocarpus distichus considering biometric fruit variables
Authors: Mendes Gleidson Guilherme Caldas , de Gusmão Mônica Trindade Abreu , Martins Thales Guilherme Vaz , Rosado Renato Domiciano Silva , Sobrinho Rayanne Savina Alencar , Nunes Andrei Caíque Pires , Ribeiro Wellington Souto , Zanuncio José Cola 
Published: March 2019

AbstractOenocarpus distichus presents economic, ecological, and dietary potential for pulp market processed in natura. Germplasm conservation and genetic improvement depend on genetic divergence studies. The objective was to quantify genetic divergence in a native population of O. distichus genotypes based on fruit biometrics. The fruit length and width, fruit mass, pulp and seed, pulp and almond thickness, and pulp yield per fruit were evaluated. All fruit biometric characteristics of O. distichus palms show genetic variability. Genetic variations among genotypes are essential for predicting heredity and heterosis, which are essential for improving O. distichus production. Pulp yield and seed mass were negatively correlated. Almond thickness and pulp, seed mass and transverse diameter were positively correlated. Genetic distances between pair of genotypes ranged from 0.07 to 48.10 with three genetically distinct groups. The seed mass, almond thickness and transverse diameter contributed to genetic divergence. Heritability estimates the genetic control that can be obtained from O. distichus germplasm. Correlations between the variable pair reduce the evaluation effort and the resources to measure the genotype allocations in heterogeneous groups presenting high genetic variability. This makes it possible to select individuals for hybridization programs with F1 generation gains. Correlation and relative contribution networks, based on relationships graphical between fruit biometric characteristics, allow the variables selection with less effort and fewer measurements. O. distichus fruit biometric characters are efficient to quantify genetic divergence between genotypes.
Aircraft measurement campaign on summer cloud microphysical properties over the Tibetan Plateau
Authors: Chang Yi , Guo Xueliang , Tang Jie , Lu Guangxian 
Published: March 2019

AbstractWe reported the first aircraft campaign on summer cloud microphysical properties conducted in July of 2014 over the Tibetan Plateau during the third Tibetan Plateau Atmospheric Sciences Experiment (TIPEX-III), and demonstrated that the summer clouds over the Tibetan Plateau were primarily characterized as mixed-phase cumulus clouds induced by strong solar radiation heating. Moreover, the characteristic number concentration of cloud droplets (2~50 μm in diameter) in developing cumuli was around 10 cm−3, which was about 1~2 orders of magnitudes lower than other continent and ocean regions, and that for large drops (>50 μm in diameter) was around 10−3 cm−3, which was also lower than other regions. The droplet spectrum distributions (DSDs) of cloud drops were much wider than other regions, indicating that the cumulus clouds over the plateau could form precipitation easier than that in other regions. Ice microphysics was characterized as very active glaciation and riming processes with high supercooled water content, which caused the formation of high concentration of graupel particles in clouds. The findings of this study suggest that these unique cloud microphysical properties formed by the high topography and clean environment of the Tibetan Plateau could induce higher precipitation efficiency when airflow passed over the plateau, so that the plateau could act as a regional “water tower”.
Unterscheiden sich Kinder mit und ohne pragmatisch-kommunikative Defizite in ihrer Mediennutzung?
Authors: Ronniger Pola , Rennecke Lisa , Petermann Franz , Melzer Jessica 
Published: March 2019

Zusammenfassung
Hintergrund Die Studie befasst sich mit dem Konsum sprachförderlicher Medien (Hörbuch, Buch, Musik) von Kindern mit und ohne Defizite in den pragmatisch-kommunikativen Fähigkeiten.
Methode Es nahmen 104 Kinder im Alter von 48 – 71 Monaten (M = 59,80; SD = 6,71) teil. Anhand einer multivariaten Varianzanalyse wird die Elterneinschätzungen zum Medienkonsum von n = 43 auffälligen (Risikogruppe, RG) und n = 61 unauffälligen (Vergleichsgruppe, VG) Kindern verglichen. Für die Gruppeneinteilung wurden die Ergebnisse der Elterncheckliste (ECL) zur Erfassung der pragmatisch-kommunikativen Fähigkeiten des SET 3 – 5 berücksichtigt (PR ≥ 26 = unauffällig).
Ergebnisse Die RG nutzt Hörbücher/-spiele und Bücher im Durchschnitt signifikant kürzer als die VG.
Diskussion Die Ergebnisse deuten darauf hin, dass Kinder mit pragmatisch-kommunikativen Defiziten die als besonders sprachförderlich eingeschätzten Medien weniger nutzen.
Der Zusammenhang von Kieferorthopädie und Sprechauffälligkeiten
Authors: Riemekasten Sandra , Peter Birke , Fuchs Michael 
Published: March 2019

ZusammenfassungErkenntnisse aus der Kontrolle der Gebissentwicklung sind elementar für Ursachenfindung und Therapie von Zahn- und Kieferfehlstellungen, können jedoch ebenso durch diese bedingt sein. Dieser Artikel soll Grundlagen für die Diagnostik und Therapie solcher Störungen darlegen, das Grundwissen hierzu erweitern und eventuelle Wissenslücken auffüllen.
Can Automated Retrieval of Data from Emergency Department Physician Notes Enhance the Imaging Order Entry Process?
Authors: Rousseau Justin , Ip Ivan , Raja Ali , Valtchinov Vladimir , Cochon Laila , Schuur Jeremiah , Khorasani Ramin 
Published: March 2019

Background When a paucity of clinical information is communicated from ordering physicians to radiologists at the time of radiology order entry, suboptimal imaging interpretations and patient care may result.
Objectives Compare documentation of relevant clinical information in electronic health record (EHR) provider note to computed tomography (CT) order requisition, prior to ordering of head CT for emergency department (ED) patients presenting with headache.
Methods In this institutional review board-approved retrospective observational study performed between April 1, 2013 and September 30, 2014 at an adult quaternary academic hospital, we reviewed data from 666 consecutive ED encounters for patients with headaches who received head CT. The primary outcome was the number of concept unique identifiers (CUIs) relating to headache extracted via ontology-based natural language processing from the history of present illness (HPI) section in ED notes compared with the number of concepts obtained from the imaging order requisition.
Results Our analysis was conducted on cases where the HPI note section was completed prior to image order entry, which occurred in 23.1% (154/666) of encounters. For these 154 encounters, the number of CUIs specific to headache per note extracted from the HPI (median = 3, interquartile range [IQR]: 2–4) was significantly greater than the number of CUIs per encounter obtained from the imaging order requisition (median = 1, IQR: 1–2; Wilcoxon signed rank p < 0.0001). Extracted concepts from notes were distinct from order requisition indications in 92.9% (143/154) of cases.
Conclusion EHR provider notes are a valuable source of relevant clinical information at the time of imaging test ordering. Automated extraction of clinical information from notes to prepopulate imaging order requisitions may improve communication between ordering physicians and radiologists, enhance efficiency of ordering process by reducing redundant data entry, and may help improve clinical relevance of clinical decision support at the time of order entry, potentially reducing provider burnout from extraneous alerts.
Interventional Oncology in Immuno-Oncology Part 2: Transcatheter Therapies
Authors: Dendy Case Meaghan , Slovak Ryan , Raja Junaid , Kim Hyun S. 
Published: March 2019

AbstractThe use of transcatheter embolization in its various forms in interventional oncology has altered the treatment paradigms for multiple types of cancer. Though direct investigation of the immunologic effects of transcatheter treatments has been limited, research on radiation therapy can be extrapolated to better understand the potential effects of radioembolization and studies on the immune response to chemotherapy can potentially explain the immune response to hepatic artery infusion and chemoembolization. Utilization of newer systemic immunotherapies in combination with various transcatheter therapies also presents the potential for improving outcomes for multiple malignancies. This review will discuss the role of transcatheter therapies in stimulating an immune response as well as the potential these techniques have to enhance the effects of systemic immunotherapy.
Communities and regularities in the behavior of investment fund managers
Authors: Flori Andrea , Pammolli Fabio , Buldyrev Sergey V. , Regis Luca , Stanley H. Eugene 
Published: March 2019

Significance
This paper relies on a unique database of fund managers’ holdings to map their behavior across asset classes. We unravel the existence of stable and persistent communities. This paper characterizes three different main behavioral attitudes: conservative, reactive, and proactive. Macroeconomic shocks temporarily perturb the configuration of the system, altering the differences between communities. This paper represents a significant step forward in understanding how heuristics, attitudes, and routines shape the behavior of expert investors. It opens a research trajectory in the analysis of behavioral interdependencies in financial markets.
Multiplication of weak equivalence classes may be discontinuous
Authors: Bernshteyn Anton 
Published: March 2019

For a countably infinite group

Γ
\Gamma

, let

W

Γ

{\mathcal {W}}_{\Gamma }

denote the space of all weak equivalence classes of measure-preserving actions of

Γ

{\Gamma }

on atomless standard probability spaces, equipped with the compact metrizable topology introduced by Abért and Elek. There is a natural multiplication operation on

W

Γ

{\mathcal {W}}_{\Gamma }

(induced by taking products of actions) that makes

W

Γ

{\mathcal {W}}_{\Gamma }

an Abelian semigroup. Burton, Kechris, and Tamuz showed that if

Γ

{\Gamma }

is amenable, then

W

Γ

{\mathcal {W}}_{\Gamma }

is a topological semigroup; i.e., the product map

W

Γ

×

W

Γ

→

W

Γ

:
(

a

,

b

)
↦

a

×

b

{\mathcal {W}}_{\Gamma } \times {\mathcal {W}}_{\Gamma } \to {\mathcal {W}}_{\Gamma } \colon (\mathfrak {a}, \mathfrak {b}) \mapsto \mathfrak {a} \times \mathfrak {b}

is continuous. In contrast to that, we prove that if

Γ

{\Gamma }

is a Zariski dense subgroup of

S
L

d

(

Z

)

{\mathrm {SL}}_d({\mathbb {Z}})

for some

d
⩾
2

d \geqslant 2

(for instance, if

Γ

{\Gamma }

is a non-Abelian free group), then multiplication on

W

Γ

{\mathcal {W}}_{\Gamma }

is discontinuous, even when restricted to the subspace

F
W

Γ

{\mathcal {FW}}_{\Gamma }

of all free weak equivalence classes.
Predicting Early Mild Cognitive Impairment With Free Recall: The Primacy of Primacy
Authors: Talamonti Deborah , Koscik Rebecca , Johnson Sterling , Bruno Davide 
Published: March 2019

Abstract

Objectives
Serial position effects have been found to discriminate between normal and pathological aging, and to predict conversion from Mild Cognitive Impairment (MCI) to Alzheimer’s disease (AD). Different scoring methods have been used to estimate the accuracy of these predictions. In the current study, we investigated delayed primacy as predictor of progression to early MCI over established diagnostic memory methods. We also compared three serial position methods (regional, standard and delayed scores) to determine which measure is the most sensitive in differentiating between individuals who develop early MCI from a baseline of cognitively intact older adults.

Method
Data were analyzed with binary logistic regression and with receiver-operating characteristic (ROC). Baseline serial position scores were collected using the Rey’s Auditory Verbal Learning Test and used to predict conversion to early MCI. The diagnosis of early MCI was obtained through statistical algorithm and consequent consensus conference. One hundred and ninety-one participants were included in the analyses. All participants were aged 60 or above and cognitively intact at baseline.

Results
The binary logistic regression showed that delayed primacy was the only predictor of conversion to early MCI, when compared to total and delayed recall. ROC curves showed that delayed primacy was still the most sensitive predictor of progression to early MCI when compared to other serial position measures.

Conclusions
These findings are consistent with previous studies and support the hypothesis that delayed primacy may be a useful cognitive marker of early detection of neurodegeneration.
Liquid Formulation of AbobotulinumtoxinA: A 6-Month, Phase 3, Double-Blind, Randomized, Placebo-Controlled Study of a Single Treatment, Ready-to-Use Toxin for Moderate-to-Severe Glabellar Lines
Authors: Ascher Benjamin , Rzany Berthold , Kestemont Philippe , Hilton Said , Heckmann Marc , Bodokh Isaac , Noah Ernst Magnus , Boineau Dominique , Kerscher Martina , Volteau Magali , Le Berre Philippe , Picaut Philippe 
Published: March 2019

Abstract

Background
Safety and efficacy of botulinum toxin A for glabellar line (GL) treatment are well established. Currently approved formulations require reconstitution before injection.

Objectives
The authors sought to assess 6-month efficacy, safety, and patient satisfaction of new ready-to-use abobotulinumtoxinA solution for injection (ASI) in patients with moderate-to-severe GL at maximum frown.

Methods
The authors conducted a phase 3, double-blind, randomized, placebo-controlled trial (NCT02353871). Patients (N = 185) were randomized (2:1) to receive ASI 50 U or placebo. GL severity was evaluated at days 8, 15, 29, 57, 85, 113, 148, and 183 employing a 4-point scale for investigator’s live assessment (ILA) and subject's self-assessment (SSA). Primary endpoint was ILA of GL at maximum frown at day 29, and secondary endpoints were ILA and SSA of GL at maximum frown (all time points), patient satisfaction with GL appearance, time to onset, and duration of action.

Results
Responder rates were significantly higher for ASI vs placebo (88.3% vs 1.4%; P &lt; 0.0001) at day 29 by ILA and all time points by ILA (P &lt; 0.0001-0.0441) and SSA (P &lt; 0.0001-0.0036). Sixty percent of patients reported onset of treatment response on or before day 3 (P &lt; 0.0001 vs placebo), and in 5% of patients, efficacy by ILA lasted 6 months (day 183; P = 0.0441 vs placebo). Patient satisfaction rates were significantly higher for ASI vs placebo at all visits (P &lt; 0.0001). Safety was comparable with the known abobotulinumtoxinA profile.

Conclusions
ASI was significantly efficacious for improving moderate or severe GL vs placebo by investigator and patient assessment. ASI was associated with high patient satisfaction, a long duration of action, and comparable safety profile to abobotulinumtoxinA.

Level of Evidence: 1
Surgical Site Infections in Aesthetic Surgery
Authors: Kaoutzanis Christodoulos , Ganesh Kumar Nishant , Winocour Julian , Hood Keith , Higdon K Kye 
Published: March 2019

Abstract
Surgical site infections represent one of the most common postoperative complications in patients undergoing aesthetic surgery. As with other postoperative complications, the incidence of these infections may be influenced by many factors and varies depending on the specific operation performed. Understanding the risk factors for infection development is critical because careful patient selection and appropriate perioperative counseling will set the right expectations and can ultimately improve patient outcomes and satisfaction. Various perioperative prevention measures may also be employed to minimize the incidence of these infections. Once the infection occurs, prompt diagnosis will allow management of the infection and any associated complications in a timely manner to ensure patient safety, optimize the postoperative course, and avoid long-term sequelae.
ngsLD: evaluating linkage disequilibrium using genotype likelihoods
Authors: Fox Emma A , Wright Alison E , Fumagalli Matteo , Vieira Filipe G 
Published: March 2019

Abstract

Motivation
Linkage disequilibrium (LD) measures the correlation between genetic loci and is highly informative for association mapping and population genetics. As many studies rely on called genotypes for estimating LD, their results can be affected by data uncertainty, especially when employing a low read depth sequencing strategy. Furthermore, there is a manifest lack of tools for the analysis of large-scale, low-depth and short-read sequencing data from non-model organisms with limited sample sizes.

Results
ngsLD addresses these issues by estimating LD directly from genotype likelihoods in a fast, reliable and user-friendly implementation. This method makes use of the full information available from sequencing data and provides accurate estimates of linkage disequilibrium patterns compared with approaches based on genotype calling. We conducted a case study to investigate how LD decays over physical distance in two avian species.

Availability and implementation
The methods presented in this work were implemented in C/C and are freely available for non-commercial use from https://github.com/fgvieira/ngsLD.

Supplementary information
Supplementary data are available at Bioinformatics online.
ORE identifies extreme expression effects enriched for rare variants
Authors: Richter F , Hoffman G E , Manheimer K B , Patel N , Sharp A J , McKean D , Morton S U , DePalma S , Gorham J , Kitaygorodksy A , Porter G A , Giardini A , Shen Y , Chung W K , Seidman J G , Seidman C E , Schadt E E , Gelb B D 
Published: March 2019

Abstract

Motivation
Non-coding rare variants (RVs) may contribute to Mendelian disorders but have been challenging to study due to small sample sizes, genetic heterogeneity and uncertainty about relevant non-coding features. Previous studies identified RVs associated with expression outliers, but varying outlier definitions were employed and no comprehensive open-source software was developed.

Results
We developed Outlier-RV Enrichment (ORE) to identify biologically-meaningful non-coding RVs. We implemented ORE combining whole-genome sequencing and cardiac RNAseq from congenital heart defect patients from the Pediatric Cardiac Genomics Consortium and deceased adults from Genotype-Tissue Expression. Use of rank-based outliers maximized sensitivity while a most extreme outlier approach maximized specificity. Rarer variants had stronger associations, suggesting they are under negative selective pressure and providing a basis for investigating their contribution to Mendelian disorders.

Availability and implementation
ORE, source code, and documentation are available at https://pypi.python.org/pypi/ore under the MIT license.

Supplementary information
Supplementary data are available at Bioinformatics online.