bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical study of gefitinib maintenance therapy after concurrent radiotherapy and chemotherapy for locally advanced NSCLC with EGFR sensitive mutations.
Authors: Xin Ying 
Published: October 2019

87 Background: To investigate the value of Gefitinib, an epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI), in the maintenance therapy of locally advanced NSCLC after concurrent radiotherapy and chemotherapy. Methods: From Jan 2010 to Jan 2015, 166 patients with locally advanced NSCLC were treated in JCH. Total 86 patients with no progress after concurrent radiotherapy and chemotherapy were selected. Within 2 to 6 weeks after therapy, eligible patients received TKI (Gefitinib 250mg/day) or were observed for 1 year. If disease progresses or intolerable adverse reactions occur, the treatment should be discontinued. Chest and abdomen CT exam were performed 2 weeks before TKI treatment, and every 2 months thereafter. The same assessment techniques were used throughout the study. Therapeutic evaluation refers to the RECIST. SPSS 19.0 was used for data analysis and processing. Survival analysis was performed by Kaplan-Meier method. Results: In TKI drug group, CR 6 cases, PR 18 cases, SD 12 cases, PD 7 cases; in observation group, CR 3 cases, PR 11 cases, SD 13 cases, PD 16 cases. The CR + PR were 54.5% and 31.8% respectively, P = 0.031. The CR + PR + SD were 81.8% and 61.4% respectively, P = 0.033. The objective remission rate and disease control rate of TKI group were higher than those of observation group. The TTP in TKI group was 13.6 months (CI: 12.88-14.32 months) and that in observation group was 10.8 months (CI: 9.87-11.73 months), P = 0.001. The median OS of TKI group was 34.5 months (CI: 32.12-36.88 months) and that of observation group was 30.3 months (CI: 28.64-31.96 months), P = 0.029. Conclusions: 1. The objective remission rate and disease control rate of TKI group were higher than those of placebo group. 2. Ohitinib was not on the market in China at the time of this study and economic reason, so palliative chemotherapy was the main way to treat condition, and no third-generation TKI drugs were used. This may be one of the reasons why the total OS in this study was not long. 3. TKI drugs can improve the disease control rate and prolong the survival time of patients with locally advanced NSCLC after concurrent radiotherapy and chemotherapy, and have less side effects.
Preliminary results of endoscopic submucosal dissection in Vietnamese patients with gastric pre-neoplasia lesion.
Authors: Duc Canh Tran , Tuyet Bui Anh , Dat Pham Quoc , Chu Nguyen Van 
Published: October 2019

91 Background: Gastric cancer is in the top three most common cancers in Vietnam and the disease is mainly detected in late stage. There is a lack of evaluation of the pre-neoplasia stage of gastric cancer and selection an appropriate and effective treatment remains still in debate. Hence, the study aims to evaluate, for the first time, the safety and efficacy of the application of endoscopic submucosal dissection (ESD) technique on Vietnamese patients with pre-neoplasia lesion in stomach. Methods: We included all patients diagnosed with lower or high-grade gastric dysplasia and hopitalized in the Department of Endoscopic and Functional Exploration in K Hospital from March 2018 to June 2019. Eligible patients were applied by the ESD technique as the standard treatment. We evaluated the efficacy and safety of after the intervention of ESD by the neoplasia recurrence rate after 3 months and the occurrence of adverse events during and after the ESD procedure described in frequency and percentage. Results: During the investigational period, we chose 65 pre-neoplasia gastric patients for the application of ESD technique. The male/female ratio was 1.09 and the mean age of patients was 58.07 years. The duration of hospitalization was about 3 days. We found 57 patients (87.69%) with location of the lesions in pylorus. The average of tumor sizes was 20.46 mm. All patients were treated with curative en bloc resection and no case was found as failure. Out of 65 patients, we found 2 patients (3%) with bleeding complication, no perforation and other post-surgery complication were identified. The average of procedure time was short (67.53 minutes). The histopathological specimen results revealed that 20 patients (30.76%) were diagnosed as cancer and 40 patients (61.53%) were diagnosed as high-grade dysplasia, all patients had a margin negative after ESD. After 3 months of treatment, all patients have no pre-neoplastic recurrence. Conclusions: Our result showed that the ESD technique is relatively safe and effective for Vietnamese patients with pre-neoplasia at stomach.
Consolidation chemoradiation improves survival in responders to first-line chemotherapy (CT) in locally advanced GBC (LA-GBC).
Authors: Agrawal Sushma , Alam Md Nawed , Rastogi Neeraj , Das KJ Maria 
Published: October 2019

97 Background: CT is the standard of care in advanced GBC [LA-GBC and metastatic GBC (M-GBC)]. The survival rates with CT are better in LA-GBC than M-GBC. Should responders to CT with good performance status (PS) be offered consolidation chemo-radiation (cCTRT) to delay progression and improve survival? There is scarcity of literature on this approach in the literature. We present our experience with this approach in LA-GBC which presents in endemic proportions in this region. Methods: We reviewed the records of consecutive GBC patients over 3 year period (2014-2016) after ethics approval. Out of 550 patients, 145 were LA-GBC who were treated with radical intent. Patients with good PS and responders to CT (partial and stable disease) but unresectable, were treated with cCTRT. Radiotherapy was given to GB bed, peri-portal, common hepatic, coeliac, superior mesentric and para aortic lymph-nodes (upto L2 vertebra) upto a dose of 45-54 Gy in 25 to 28 fractions along with concurrent capecitabine @ 1250 mg/m2. Response to treatment was categorised according to RECIST criteria based on CECT abdomen. Treatment toxicity, OS and factors affecting OS were computed by Cox-Regression analysis. Results: Burden of disease was [T3 (55%), T4 (45%), N1 (30%), N2 (70%)]. 65% patients underwent CT alone and 35% received CT followed by cCTRT. 10 patients underwent Radical Surgery ( 6 after CT and 3 after cCTRT). The incidence of grade 2 toxicity were: gastritis (10%) and diarrhoea (5%). 65% patients achieved partial response (PR), 12% static disease (SD), 10% progressive disease (PD) and 13% were non-evaluable (NE) [ did not complete 6 cycles CT or lost to follow-up]. At a median follow-up of 8 months (IQR 5-15 months), the median OS was 9 months for all, 7 months with CT and 14 months with cCTRT arm (p=0.04).The median OS was 57 months for CR, 12 months for PR and SD, 7 months for PD and 5 months for NE (p=0.008). OS was 10 months for KPS >80 and 5 months for KPS <80 (p=0.008). Type of treatment and response to treatment were retained as independent prognostic factors affecting OS. Conclusions: CT followed by cCTRT doubles survival in responders with good PS. This innovative approach should be tested in a randomised study.
Systematic Approach to Selecting and Preparing a Medical Power of Attorney in the Gynecologic Oncology Center
Authors: Zhukovsky Donna S. , Soliman Pamela T. , Mathew Boby , Mills Sarah , Bodurka Diane , Frumovitz Michael , Meyer Larissa A. , Westin Shannon , Nowitz Marisa , Archie LaShan , Fenton Shauna , Lang Kai , Williams Janet L. , Boving Valentine , Bruera Eduardo 
Published: October 2019

PURPOSE: Advance care planning (ACP) supports national priorities of patient engagement, person-centered care, and safety. A systematic approach is uncommon in most care settings. Our institution offers all patients with cancer new to the institution an opportunity to select and prepare a medical decision maker (MDM) after social work counseling. The goals of this study were to determine the success of a systematic institutional process for selecting a prepared MDM. The primary objectives were that (1) 70% or more of new patients would have one or more documented social work ACP discussions by the third office visit within 4 months, and (2) there would be a two-fold increase in scanned medical power of attorney (MPOA) documents available in the electronic health record (EHR). The secondary objectives were (1) improved surrogate preparedness for medical decision making, and (2) to determine whether patients with metastatic disease demonstrated greater readiness for selection of an MDM than those with localized disease. MATERIALS AND METHODS: We conducted a retrospective chart review of consecutive gynecology oncology outpatients. RESULTS: Of 133 patients, 93 (70%) had metastatic disease. The median number of visits was two (one to three). Forty-seven patients (39.3%) met with social work by visit 3. Review of ACP notes suggested that most patients were in the early stages of selecting a prepared MDM. At visit 1, 39 (29.3%) reported having an advance directive document; 14 (10.5%) had an MPOA in the EHR. There was no increase by visit 3. Fewer patients with metastatic disease than those with localized cancer (32.3% v 67.5%; P = .001) had three visits; no other parameter, including presence of MPOA documents in the EHR, achieved statistical significance between groups. CONCLUSION: Current processes fail to engage patients in selecting and preparing an MDM.
The Use and Value of Social Information in Selective Selling of Exclusive Products
Authors: Momot Ruslan , Belavina Elena , Girotra Karan 
Published: October 2019

We consider the use and value of social-network information in selectively selling goods and services whose value derives from exclusive ownership among network connections or friends. Our model accommodates customers who are heterogeneous in their number of friends (degree) and their proclivity for social comparisons (conspicuity). Firms with information on either (or both) of these characteristics can use it to make the product selectively available and to personalize prices. We find that firms’ preferred customers are low degree and high conspicuity, with the conspicuity threshold nondecreasing in degree. Interestingly, although both degree and conspicuity levels are relevant to curating the desired customer base, we find that firms do not need conspicuity information to do so; its absence can be substituted by incentivizing customers to self-select. There is no such recourse for the absence of degree information. As a result, degree information is typically more valuable than conspicuity information. Our analysis suggests that there are two canonical categories of social information—less valuable “consonant” information on characteristics where firm and customer preferences are aligned and more valuable “competing” information where preferences are misaligned. Customers can be incentivized to act in a way that their actions are a perfect substitute for consonant information, making it less valuable. This paper was accepted by Gad Allon, operations management.
An Emotional Literacy Improvement (ELI) Program for EFL Teachers: Insiders’ Views
Authors: Eraldemir-Tuyan Seden 
Published: October 2019

<p>If the challenges of today's world are to be met, then there is a need to give more prominence to emotion in education, i.e. indulging the personal, emotional and spiritual aspects of teaching, and promoting the teachers’ social-emotional competencies along with the schooling influence. In this respect, structuring the contents of in-service programs has gained vital importance in all fields of education including English Language Teaching (ELT). This action research study involved 17 EFL instructors to enhance their emotional literacy regarding learning in self and in others and consequently develop behaviors that would be caused by finding out about emotional intelligence. Relatedly, it was aimed to set up a framework of a teacher development program that the instructors at a foreign language school at a state university in Turkey improve their emotional literacy skills and create opportunities to impart these skills to their students as well as to people in their personal lives. The article reports on the participants’ and the researcher’s views regarding the maturation of an emotional literacy improvement program for in-service professional development purposes in ELT context.</p>
Incidence of thyroid cancer and epidemiologic determinants of the condition: Role of ionizing radiation
Authors: Tronko N. D. , Boguslavsky V. P. , Prisyazhnyuk A. Ye. , Bolshova Ye. V. 
Published: October 2019

As a result of the Chernobyl accident, a significant part of Ukraine was contaminated with radionuclides. According to UNSCEAR, the activity of material released into the environment from the destroyed active zone of the reactor was about 50 MKi, among which the share of radionuclides of iodine, cesium and tellurium was 10-20%. Despite the fact that the prompt implementation of iodine prophylaxis made it possible to reduce the dose load on the thyroid gland, nevertheless, a significant part of the child and adult population received radiation doses of the thyroid gland, which pose a serious danger in the development of possible long-term oncological consequences. Based on dose calculations according to the most conservative model of single dose of radioactive iodine, the number of children living in the 8 most affected areas of Ukraine affected by iodine radionuclides and exposed to doses in excess of 200 cGy is estimated to be 12,000 or more, in the dose range up to 200 cGy - 79 500, up to 30 cGy - 38 000.
Available information on thyroid doses in Ukraines population, on the one hand, and information on the carcinogenic effects of this organs radiation, accumulated to date in the world, on the other hand, indicate the need for carefully planned epidemiological studies aimed at assessing the risk of this pathology in victims. At the same time, the effectiveness of such studies, and, consequently, the development of preventive measures to reduce the effects of radiation in the future, will largely depend on taking into account the characteristics of the epidemiological study of the role of the radiation factor in the development of thyroid cancer.
In connection with the foregoing, the aim of this work was to generalize the information accumulated to date in the world, reflecting deficiencies in the study of the epidemiology of radiation-induced thyroid cancer, as well as confirming the need for further development and improvement of these studies.
Workshop on «Essential» Phospholipids in the Treatment of Diabetes Mellitus and Dyslipidemias
Authors: Bespalova V. A. , Kundurovich M. 
Published: October 2019

A scientific and practical symposium Essential phospholipids in the treatment of diabetes mellitus and dyslipidemia organized by RON-PULENK RORER (Cologne, Germany) was held at the State Central Scientific Medical Library of the Ministry of Health of Russia.
The basic concept of the development of dyslipidemia (DLP) and the working classification of this metabolic state were presented in a report by Yu. A. Knyazev (Moscow). In the message K. Gundermann et al. (Cologne, Germany) the mechanism of action of essential phospholipids (EPL) at the molecular level, the level of insulin receptor and postreceptor interactions in cytomembranes, as well as in lipolytic and cholinesterizing enzyme systems was described.
The feasibility of using EPL preparations for the prevention of diabetic angiopathies (AP) by transplanting pancreatic incretory cell cultures, with conservative and surgical treatment of AP with the aim of stabilizing or even reversing the development of atherosclerotic vascular lesions, was substantiated in a report by A. A. Chirkin et al. (Vitebsk, Belarus). The results of the study of intravascular microcirculation in patients with diabetes with clinical signs of AP made it possible to evaluate lipostabil (a drug containing EPL and prescribed together with hypoglycemic agents) as an effective tool in the plasma-cell type of microcirculatory disorders in patients with diabetes aged 19 to 68 years (I. M Kakhnovsky et al., Moscow).
Under the influence of lipostabil forte, an increase in insulin sensitivity is possible (L. L. Vakhrusheva et al., Moscow), which underlies a decrease in the need for exogenous insulin and a tendency to normalize indicators of carbohydrate and fat metabolism, the level of counterinsulin hormones. 6 months after the start of lipostabil forte administration, an inhibition of AP progression was noted against the background of an adequate dose of insulin.
Schinus terebinthifolius essential oil and fractions in the control of Aedes aegypti
Authors: Bortolucci Wanessa de Campos , De Oliveira Herika Line Marko , Silva Eloísa Schineider , Campo Caio Franco de Araújo Almeida , Gonçalves José Eduardo , Piau Junior Ranulfo , Colauto Nelson Barros , Linde Giani Andrea , Gazim Zilda Cristiani 
Published: October 2019

Several technologies have been developed to control Aedes aegypti, mainly studies on isolated plant molecules. The Schinus terebinthifolius (Raddi) (Anacardiaceae), popularly known as pink pepper is a plant widely used in reforestation of degraded areas and its fruits are used as condiments. The objective of this work was to investigate the potential of essential oils (EOs) and fractions (FRs) obtained from fresh fruits and leaves of S. terebinthifolius. The EOs were obtained by hydrodistillation (2 hours), fractionated on a chromatographic column using as the stationary phase silica gel 60 (0.063-0.2mm), mobile phases: n-hexane, dichloromethane, ethyl acetate and methanol and chemically evaluated by gas chromatography coupled to mass spectrometer (GC/MS). EOs and FRs were tested against larvae of the third stage and pupae of Ae. aegypti by Immersion Test at concentrations ranging from 500.00 to 0.003 mg mL-1 (v/v). The hexane FRs obtained from fruits and leaves were the ones that showed the greatest activity on the larvae (LC99.9= 0.60 mg mL-1 and LC99.9 0.64 mg mL-1, respectively) and pupae (LC99,9 = 2.51 mg mL-1 and 2.61 mg mL-1, respectively). These results were confirmed by the anticholinesterase activity where the hexane (fruit and leaf) FRs presented the highest inhibitory potential on the acetylcholinesterase enzyme (0.156 mg mL-1 and 0.312 mg mL-1, respectively), suggesting the likely mechanism of action. The larvicidal potential can be explained by the presence of the major compounds bicyclogermacrene and germacrene D in the hexane FRs, indicating in this way that they may replace or even act in synergisms with conventional chemical larvicides. In this way the present study opens the field for new researches, aiming the development of products with the compounds bicyclogermacrene and germacrene D, as an alternative in the control of this culicide.
Organic matter and moringa leaf extract’s effects on the physiology and fruit quality of red seedless watermelon (Citrullus lanatus)
Authors: Dalorima Tahir , Khandaker Mohammad Moneruzzaman , Zakaria Abd Jamil , Mohd Khamsah Suryati , Sajili Mohammad Hailmi , Badaluddin Noor Afiza , Hasbullah Mohammed 
Published: October 2019

This study was designed to assess the effects of different types of organic matter on the quality and biochemical properties of red seedless watermelon. The research was a single factor experiment, which involved six (6) treatments and four (4) replications. Watermelon grown and harvested from five (5) different organic matter sources, namely; vermicompost (VC), poultry manure (PM), cow dung (CD), goat dung (GD), and moringa leaf extract (MLE), at the rates of 10 ton, 20 ton, 30 ton, 30 ton, and 3000 L ha-1, respectively, were used in this study. The results revealed that the treatment of vermicompost improved the chlorophyll content, chlorophyll fluorescence, stomatal conductance, internal carbon dioxide, net photosynthetic rate, fruit weight and mineral nutrient content of watermelon. The application of cow dung reduced the rind thickness and increased the TSS and antioxidant activity of the watermelon. The goat dung treatment significantly affected fruit size, juice content and the pH content of the watermelon’s fruit juice. The poultry manure (PM) and moringa extract (MLE) treatments resulted in the highest anthocyanin content of all the watermelon. Although all the organic matter, in their unique ways, improved the quality of red seedless watermelon, the study shows that the vermicompost application had better growth, yield and improvement in the quality of watermelon.
CARACTERIZAÇÃO DO GÊNERO STAND UP
Authors: Andrade Valdete , Ottoni Maria Aparecida Resende 
Published: October 2019

Neste estudo, temos como objetivo realizar a análise discursiva crítica de exemplares do gênero stand up, com base nos pressupostos da Análise de Discurso Crítica (ADC). Para tanto, selecionamos quatro apresentações de stand up, retirados de um corpus composto por vinte e oito (28) vídeos, publicados entre 2011 e 2015, e veiculados na internet pelo site do YouTube. Por meio do material empírico, o texto transcrito, buscamos relações dialéticas entre discurso e práticas sociais. Assim, adotamos a proposta de Fairclough (2003) de se analisar os modos pelos quais o discurso figura nas práticas sociais - modos de agir, de representar e de ser - articulados aos três significados - o acional, o representacional e o identificacional. O gênero em questãofoi analisado em termos de atividade, relações sociais e tecnologias da comunicação. Este estudo evidencia potencialidades da ADC, para a análise de gêneros, e se constitui em uma importante contribuição para esse campo teórico e, especialmente, para a caracterização de outros gêneros orais.