bluuebunny/crossref_metadata_2025_split huggingface dataset:
KONSEP KESEDERHANAAN DALAM BUDDHISME (THE CONCEPT OF MODERATION IN BUDDHISM )
Authors: Mohd Naaim Nor Atiqah , Awang Jaffary 
Published: November 2018

Buddhism is the oldest religion still in practice today. The arrival of the religion was a reaction against the oppression by the self-centred Brahmins. The founders of Buddhism were Kshatriyas (warriors) who suffered discrimination towards the lower-class citizens. Most of the religions ever existed in India long time ago are non-existent to date. However, the teachings of Buddha (Dhamma) persevere as a need to its followers up until today. For that reason, Buddha considers himself a religious teacher to propagate enlightenment and wellbeing for all mankind. Fundamentally, Buddha leads his followers to a normal life that is a life void of extremism such as denial of self-indulgence or total obedience to self-desire and self-dependence on a substance for the sake of pleasure. There is a variety of teachings of Buddha to his followers. One in particular is the concept of moderation. Therefore, this article will explain the concept of moderation by Buddha. The methodology used in this research is qualitative method by referring to library research from theses, journals, newspapers and books related to the research topic. Based on the research, the researcher noted that the concept of moderation comes in two aspects namely theoretical and practical aspects. The theoretical aspect recorded an explanation by Buddha on the Law of Dependent Origination known as patticasamuppada. Meanwhile the practical aspect centres around the Eight-Fold Path which has eight principles and has to be applied by every follower.
The Mosque Based Islamic Education In Guangzhou China
Authors: Basri Husen Hasan , Ta’rif Ta’rif 
Published: November 2018

This writing constitutes a research outcome regarding the Mosque based Islamic education in Guangzhou, China that aims at finding out the form of the mosque based Islamic education in relation to the implementation, student, teacher, material, means and facilities and financing. This research adopts an explorative qualitative approach with data collection through interview, site observation and documentation study. Through an observation against four mosques in Guangzhou, it is found a mosque role in the Islamic religion education. The Islamic religion education is conducted by its management and congregation of the mosque. The learning place is conducted in a building separated from the mosque although some of them conducts the learning process at their mosque. A material is regarding the Islamic basic teaching and Arabic language. The teacher comes from the management of the mosque itself who is Leader (Ahong). The students come from youth, teenagers and adult ore even elderly.
The Approach of Muhammad Farid Wajdi to the Validity of Prophethood of Muhammad (p.b.u.h) and His Role in Establsihing a Civilized Socity
Authors: Abdul Rahim Adibah 
Published: November 2018

This paper attempts to examine the approach of an Egyptian scholar, Muhammad Farid Wajdi, in his study of Prophet Muhammad (p.b.u.h). Compared to other studies on Prophet Muhammad (p.b.u.h) which are mostly historical and descriptive in nature, the approach of Wajdi is based on a scientific and rational method. Although Wajdi’s extensive writings are on various aspects of Prophet Muhammad (p.b.u.h), this paper focuses on his arguments on the validity of the prophethood and the revelation and role of the Prophet (p.b.u.h) in establishing a civilized society. The evaluation of the validity of prophethood is necessary to respond to the misrepresentation of Western orientalists of Prophet Muhammad (p.b.u.h) and their rejection of his prophethood. The role of the Prophet (p.b.u.h) in establishing a civilized society is also highlighted to invalidate the claim of the West that the Prophet’s role was only confined to the spiritual life of individuals, whilst disregarding the social, political and economic aspects. Based on his observations and evidences, it can be justifiably claimed that Wajdi is able to refute the misrepresentation of Islam, in general, and Prophet Muhammad (p.b.u.h), in particular.
Four weeks of exercise early in life reprograms adult skeletal muscle insulin resistance caused by a paternal high‐fat diet
Authors: Falcão‐Tebas Filippe , Kuang Jujiao , Arceri Chelsea , Kerris Jarrod P. , Andrikopoulos Sofianos , Marin Evelyn C. , McConell Glenn K. 
Published: November 2018

Key points
A paternal high‐fat diet/obesity before mating can negatively influence the metabolism of offspring.
Exercise only early in life has a remarkable effect with respect to reprogramming adult rat offspring exposed to detrimental insults before conception.
Exercise only early in life normalized adult whole body and muscle insulin resistance as a result of having a high‐fat fed/obese father.
Unlike the effects on the muscle, early exercise did not normalize the reduced adult pancreatic beta cell mass as a result of having a high‐fat fed/obese father.
Early‐life exercise training may be able to reprogram an individual whose father was obese, inducing long‐lasting beneficial effects on health.
AbstractA paternal high‐fat diet (HFD) impairs female rat offspring glucose tolerance, pancreatic morphology and insulin secretion. We examined whether only 4 weeks of exercise early in life could reprogram these negative effects. Male Sprague–Dawley rats consumed a HFD for 10 weeks before mating with chow‐fed dams. Female offspring remained sedentary or performed moderate intensity treadmill exercise (5 days week−1, 60 min day−1, 20 m min−1) from 5 to 9 weeks of age. Paternal HFD impaired (P < 0.05) adult offspring whole body insulin sensitivity (i.p. insulin sensitivity test), as well as skeletal muscle ex vivo insulin sensitivity and TBC1D4 phosphorylation. It also lowered β‐cell mass and reduced in vivo insulin secretion in response to an i.p. glucose tolerance test. Early‐life exercise in offspring reprogrammed the negative effects of a paternal HFD on whole body insulin sensitivity, skeletal muscle ex vivo insulin‐stimulated glucose uptake and TBC1D4 phosphorylation and also increased glucose transporter 4 protein. However, early exercise did not normalize the reduced pancreatic β‐cell mass or insulin secretion. In conclusion, only 4 weeks of exercise early in life in female rat offspring reprograms reductions in insulin sensitivity in adulthood caused by a paternal HFD without affecting pancreatic β‐cell mass or insulin secretion.
“Core Stability”: Should There Be a Bigger Focus on Foundational Skills in the Kinesiology Curriculum?
Authors: Braun Barry , Williams Nancy I. , Garber Carol Ewing , Hickey Matthew 
Published: November 2018

As the discipline of kinesiology ponders what should compose a kinesiology curriculum, it is worth considering the broad context. What is our responsibility to imbue students with values, viewpoint, and a vocabulary that facilitates their success in a context greater than our discipline? How do we decide what those things are (e.g., professional integrity, analytical thinking, cultural understanding, social responsibility, problem solving, leadership and engaged citizenship, effective communication, working collaboratively, preparation for lifelong learning)? How do we create a curriculum that provides sufficient understanding of disciplinary knowledge and critically important foundational skills? The purpose of this paper is to provide a jumping-off point for deeper discussion of what our students need most and how we can deliver it.
IND-Enabling Studies for a Clinical Trial to Genetically Program a Persistent Cancer-Targeted Immune System
Authors: Puig-Saus Cristina , Parisi Giulia , Garcia-Diaz Angel , Krystofinski Paige E. , Sandoval Salemiz , Zhang Ruixue , Champhekar Ameya S. , McCabe James , Cheung-Lau Gardenia C. , Truong Nhat A. , Vega-Crespo Agustin , Komenan Marie Desiles S. , Pang Jia , Macabali Mignonette H. , Saco Justin D. , Goodwin Jeffrey L. , Bolon Brad , Seet Christopher S. , Montel-Hagen Amelie , Crooks Gay M. , Hollis Roger P. , Campo-Fernandez Beatriz , Bischof Daniela , Cornetta Kenneth , Gschweng Eric H. , Adelson Celia , Nguyen Alexander , Yang Lili , Witte Owen N. , Baltimore David , Comin-Anduix Begonya , Kohn Donald B. , Wang Xiaoyan , Cabrera Paula , Kaplan-Lefko Paula J. , Berent-Maoz Beata , Ribas Antoni 
Published: November 2018

Abstract

Purpose:
To improve persistence of adoptively transferred T-cell receptor (TCR)–engineered T cells and durable clinical responses, we designed a clinical trial to transplant genetically-modified hematopoietic stem cells (HSCs) together with adoptive cell transfer of T cells both engineered to express an NY-ESO-1 TCR. Here, we report the preclinical studies performed to enable an investigational new drug (IND) application.

Experimental Design:
HSCs transduced with a lentiviral vector expressing NY-ESO-1 TCR and the PET reporter/suicide gene HSV1-sr39TK and T cells transduced with a retroviral vector expressing NY-ESO-1 TCR were coadministered to myelodepleted HLA-A2/Kb mice within a formal Good Laboratory Practice (GLP)–compliant study to demonstrate safety, persistence, and HSC differentiation into all blood lineages. Non-GLP experiments included assessment of transgene immunogenicity and in vitro viral insertion safety studies. Furthermore, Good Manufacturing Practice (GMP)–compliant cell production qualification runs were performed to establish the manufacturing protocols for clinical use.

Results:
TCR genetically modified and ex vivo–cultured HSCs differentiated into all blood subsets in vivo after HSC transplantation, and coadministration of TCR-transduced T cells did not result in increased toxicity. The expression of NY-ESO-1 TCR and sr39TK transgenes did not have a detrimental effect on gene-modified HSC's differentiation to all blood cell lineages. There was no evidence of genotoxicity induced by the lentiviral vector. GMP batches of clinical-grade transgenic cells produced during qualification runs had adequate stability and functionality.

Conclusions:
Coadministration of HSCs and T cells expressing an NY-ESO-1 TCR is safe in preclinical models. The results presented in this article led to the FDA approval of IND 17471.
Circulating Cytokines Predict Immune-Related Toxicity in Melanoma Patients Receiving Anti-PD-1–Based Immunotherapy
Authors: Lim Su Y. , Lee Jenny H. , Gide Tuba N. , Menzies Alexander M. , Guminski Alexander , Carlino Matteo S. , Breen Edmond J. , Yang Jean Y.H. , Ghazanfar Shila , Kefford Richard F. , Scolyer Richard A. , Long Georgina V. , Rizos Helen 
Published: November 2018

Abstract

Purpose:
Combination PD-1 and CTLA-4 inhibitor therapy has dramatically improved the survival of patients with advanced melanoma but is also associated with significant immune-related toxicities. This study sought to identify circulating cytokine biomarkers of treatment response and immune-related toxicity.

Experimental Design:
The expression of 65 cytokines was profiled longitudinally in 98 patients with melanoma treated with PD-1 inhibitors, alone or in combination with anti-CTLA-4, and in an independent validation cohort of 49 patients treated with combination anti-PD-1 and anti-CTLA-4. Cytokine expression was correlated with RECIST response and immune-related toxicity, defined as toxicity that warranted permanent discontinuation of treatment and administration of high-dose steroids.

Results:
Eleven cytokines were significantly upregulated in patients with severe immune-related toxicities at baseline (PRE) and early during treatment (EDT). The expression of these 11 cytokines was integrated into a single toxicity score, the CYTOX (cytokine toxicity) score, and the predictive utility of this score was confirmed in the discovery and validation cohorts. The AUC for the CYTOX score in the validation cohort was 0.68 at PRE [95% confidence interval (CI), 0.51–0.84; P = 0.037] and 0.70 at EDT (95% CI, 0.55–0.85; P = 0.017) using ROC analysis.

Conclusions:
The CYTOX score is predictive of severe immune-related toxicity in patients with melanoma treated with combination anti-CTLA-4 and anti-PD-1 immunotherapy. This score, which includes proinflammatory cytokines such as IL1a, IL2, and IFNα2, may help in the early management of severe, potentially life-threatening immune-related toxicity.
See related commentary by Johnson and Balko, p. 1452
Eastern Arctic Ocean Diapycnal Heat Fluxes through Large Double-Diffusive Steps
Authors: Polyakov Igor V. , Padman Laurie , Lenn Y.-D. , Pnyushkov Andrey , Rember Robert , Ivanov Vladimir V. 
Published: November 2018

AbstractThe diffusive layering (DL) form of double-diffusive convection cools the Atlantic Water (AW) as it circulates around the Arctic Ocean. Large DL steps, with heights of homogeneous layers often greater than 10 m, have been found above the AW core in the Eurasian Basin (EB) of the eastern Arctic. Within these DL staircases, heat and salt fluxes are determined by the mechanisms for vertical transport through the high-gradient regions (HGRs) between the homogeneous layers. These HGRs can be thick (up to 5 m and more) and are frequently complex, being composed of multiple small steps or continuous stratification. Microstructure data collected in the EB in 2007 and 2008 are used to estimate heat fluxes through large steps in three ways: using the measured dissipation rate in the large homogeneous layers; utilizing empirical flux laws based on the density ratio and temperature step across HGRs after scaling to account for the presence of multiple small DL interfaces within each HGR; and averaging estimates of heat fluxes computed separately for individual small interfaces (as laminar conductive fluxes), small convective layers (via dissipation rates within small DL layers), and turbulent patches (using dissipation rate and buoyancy) within each HGR. Diapycnal heat fluxes through HGRs evaluated by each method agree with each other and range from ~2 to ~8 W m−2, with an average flux of ~3–4 W m−2. These large fluxes confirm a critical role for the DL instability in cooling and thickening the AW layer as it circulates around the eastern Arctic Ocean.
64-multidetector CT anatomical assessment of the feline bronchial and pulmonary vascular structures
Authors: Panopoulos Ioannis , Auriemma Edoardo , Specchi Swan , Diana Alessia , Pietra Marco , Papastefanou Anastasia , Zini Eric , Cipone Mario 
Published: November 2018

Objectives The aim of the study was to provide a detailed anatomical study of the feline bronchial and vascular structures by using CT angiography (CTA). Methods Adult cats with no respiratory clinical signs were enrolled in a CTA protocol to provide an anatomical study of the thorax. The dimensions, number of branches and branching pattern (monopodial vs dichotomic) of both bronchial and pulmonary vascular structures were evaluated under positive inspiration apnoea. A linear generalised estimating equations analysis (Spearman’s rho) was used to identify statistical correlation between tracheal diameter, age and body weight of the cats. Results Fourteen cats met the inclusion criteria. The pulmonary arteries had larger diameters than the pulmonary veins, and the pulmonary veins had larger diameters than the bronchial structures. A higher number of segmental bronchial and pulmonary vascular branches was observed in the left caudal lung lobe than in the other lobes. The monopodial branching pattern of both bronchial and pulmonary vascular structures was predominant in all cats of our study (100%) in cranial, caudal and right middle lung lobes, while a dichotomic branching pattern of the bronchial and pulmonary vascular structures of the accessory lung lobe was seen in 13 cats (93%). Thirteen cats (93%) had three pulmonary vein ostia, and one cat (7%) also presented with an additional left intermediate pulmonary vein ostium. Variation in the number of segmental pulmonary vein branches was noted in the right caudal lung lobe. There was no statistical correlation between tracheal diameter, age and weight. Conclusions and relevance Architecture of the feline bronchovascularr structures belongs to a mixed type of monopodial and dichotomic branching pattern. In cats, the pulmonary venous drainage system predominately presents three pulmonary vein ostia. Variations in the type of formation and the number of branches of the pulmonary venous drainage system were noted.
Resection versus preservation of the middle turbinate in surgery for chronic rhinosinusitis with nasal polyposis: A randomized controlled trial
Authors: Hudon Marc-Antoine , Wright Erin D. , Fortin-Pellerin Etienne , Bussieres Marie 
Published: November 2018

Background Chronic rhinosinusitis (CRS) affects up to 16% of the population. When medical treatment fails, endoscopic sinus surgery (ESS) is considered. The value of resecting the middle turbinate to optimize surgical outcomes has been hypothesized but remains controversial and unproven. Whether the middle turbinate should be left in place or resected is controversial. Our objective is to determine if middle turbinectomy improves objective surgical outcomes after ESS. Methods Sixteen patients (15 men, 15 primary surgery) undergoing bilateral complete ESS for CRS with nasal polyposis were recruited. Nasal cavities were randomized so that middle turbinectomy was performed on one side while the middle turbinate was preserved on the other. Each participant acted as their own control. Nasal cavities were compared using Perioperative Sinus Endoscopy (POSE) and Lund-Kennedy (LKES) scores pre-operatively, and at 1, 3 and 6 months after ESS. Results were analyzed using Wilcoxon signed-rank test. Results Pre-operatively, the POSE (12.4 ± 2.9 vs 12.8 ± 2.6, p = 0.33, for the preserved side and the resected side, respectively) and LKES (5.0 ± 1.0 vs 4.8 ± 1.2, p = 0.33) scores were similar between sides. During follow up, resection was associated with more crusting at 1 month following ESS (1.0 ± 0.7 vs 0.4 ± 0.6, p = 0.02). There was a small, but statistically significant, difference between the nasal cavities at 3 months, where the resected side showed better endoscopic appearance (2.0 ± 2.2 vs 3.4 ± 2.8, p = 0.01). No difference was found at 6 months. Frontal sinus scores were similar between sides at 6 months (0.7 ± 0.5 vs 0.7 ± 0.5, p = 1.00). Conclusion Our results show no sustained objective endoscopic benefit of routine middle turbinectomy, at least within the first six postoperative months, in patients undergoing primary ESS for CRS with polyposis. Trial registration NCT, NCT02855931 . Registered 16 August 2016.
Estudio arqueoastronómico de dos santuarios ibéricos en abrigos rocosos: Cueva del Rey Moro (Ayora, Valencia) y Cueva Negra (Fortuna, Murcia)
Authors: Esteban César , Ocharan Ibarra José Ángel 
Published: November 2018

Presentamos un estudio arqueoastronómico de dos santuarios rupestres situados en abrigos rocosos, Cueva del Rey Moro y Cueva Negra. Cueva del Rey Moro es un santuario ibérico asociado al poblado de Castellar de Meca. Aunque descartamos resultados anteriores que proponían la orientación del núcleo del santuario hacia el ocaso del solsticio de verano, encontramos dos posibles marcadores de ocaso solar en el día mitad entre solsticios (fecha cercana al equinoccio) y en el solsticio de verano en sendos cerros del horizonte occidental. Cueva Negra fue un importante lugar de culto en época romana como atestiguan los tituli picti encontrados en su interior, aunque también se evidencia su uso cultual durante época ibérica. Nuestro estudio indica la existencia de un marcador muy preciso del día mitad entre solsticios sobre la ladera de la Sierra de Abanilla, aunque sin duda, el resultado más interesante es que el orto solar sobre la cumbre puntiaguda de dicha sierra, el pico Zulum, se produce, en la actualidad, el 27 de marzo, justamente la fecha del calendario juliano que se recoge en varias inscripciones de los tituli picti, y que podría corresponder con la festividad de la lavatio de la Magna Mater. Este espectacular orto pudo haberse utilizado como marcador de la fecha de la celebración principal del santuario romano si las inscripciones (al menos aquellas que muestran dicha fecha) hubieran sido realizadas durante el siglo III d.C., pues en ese siglo las fechas de los calendarios juliano y gregoriano actual coincidieron. Este resultado es consistente con los valores bajos de la horquilla de datación paleográfica propuesta para las inscripciones.
The historical dynamics of Kaaps – then and now
Authors: Kotzé Ernst 
Published: November 2018

In this contribution, the processes in the formation of language operating in the past and at present are discussed, and applied in particular to Kaaps. Concepts such as pidginisation and creolisation as mechanisms of renewal, and also as linguistic effects of social forces, are clarified, in addition to the often contentious process of standardisation. The focus will also fall on the important role of Cape Muslim Afrikaans as nuclear dialect of Kaaps, and Kaaps as the matrix dialect (or matrilect, for short) of Afrikaans. In addition, the historical value of Arabic Afrikaans (the written form of Cape Muslim Afrikaans from ca. 1815 to 1950), both as phonetic record and lexical documentation of the vocabulary of the speakers, are highlighted. Lastly, the historical and modern characteristics of Kaaps are scrutinised as a language variety in which both the timber rings of centuries gone by and the buds of new developments are in evidence.
Cicero Defining the Stoic Science of Divination
Authors: Hahmann Andree 
Published: November 2018

AbstractThis paper is devoted to the Stoic definition of divination as reported by Cicero. It proposes a novel reading that coherently combines the distinct versions offered inDe divinatione. Especially important is the proper understanding of the close relationship between providence, fate, and chance. I argue that the Stoic understanding of chance already contains a reference to divine will, which is why the Stoics can equally claim that divination is devoted to chance and providence. This sheds new light both on the Stoic science of divination and the systematic involvement of providence, fate, and divination in Stoic philosophy.
Multi-objective distance minimization problems – applications in technical systems
Authors: Mostaghim Sanaz , Steup Christoph , Zille Heiner 
Published: November 2018

Abstract
This article describes the Distance Minimisation Problem (DMP) from a metaheuristic optimisation point of view. The problem is motivated by real applications and can be used to test the performance of optimisation methods like Evolutionary Algorithms. After formally describing the problem and its extensions using different metrics or dynamics, we perform experiments with well-known metaheuristic methods to demonstrate the performance on various DMP instances. The results show that modern algorithms like NSGA-II and SMPSO can struggle with this kind of problem under certain conditions, especially when Manhattan distances are used. On the other hand, specialised methods like GRA lack diversity of solutions in some cases. This indicates that even modern and powerful metaheuristic algorithms need to be chosen with care and with the respective optimisation task in mind.