bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Many Uses of Anti-Money Laundering Regulation—Over Time and into the Future
Authors: Bergström Maria 
Published: March 2019

AbstractGiven the fast development of the field of AML Regulation, this Article aims to answer the following questions: First, how is money laundering dealt with and regulated on the EU level? Second, to which legal concerns do the chosen regulatory strategy give rise? Accordingly, this Article provides an overview of the various regulatory strategies in the global and EU regional AML Regime while at the same time points out some of the most pressing legal concerns in AML Regulation. These include the blurred line between administrative and criminal law measures and the protection of individual rights and fundamental freedoms including data protection and privacy issues in administrative and criminal law contexts respectively. Although briefly mentioning the global and international context, the focus of this Article is the EU regulatory action, its outcome and critique, and possible future.
Some Reflections on Dignity as an Alternative Legal Concept in Data Protection Regulation
Authors: de Hingh Anne 
Published: March 2019

AbstractAs the use of the Internet and online platforms grows, the scale of collecting and processing personal data and turnovers have increased correspondingly.1At the same time, public awareness about the Internet turning into a genuine profiling and advertisement machine, as well as a powerful surveillance instrument, grows. More people today are concerned about the ways in which public and private actors store and use private information. Many individuals note that they lose sight of the consequences once they give consent to the collection of their sometimes most intimate personal data. The Snowden revelations and the recent Facebook and Cambridge Analytica scandal have only reinforced this public awareness.Objections against these data processing practices cannot be explained as breaches of data protection or privacy regulation alone. In this Article, it is argued that recently passed regulations fail to solve the unease of data subjects as other, more fundamental values are at stake here. A different or complementary ethical and legal framework is needed to interpret this generally felt unease vis-à-vis current data practices and secondly to confront future developments on the data market. The concept of human dignity may be a helpful perspective in this respect. In the context of data processing, human dignity is generally interpreted in a quite specific manner, such as contributing to the empowerment and self-determination of autonomous individuals. It can be argued, however, that human dignity—in the context of the commodification and commoditization of online personal data—should be seen in a different, quite opposite, light. In sum, future regulation of privacy and data protection attention should shift towards more constraining dimensions of human dignity.
The Carles Puigdemont Case: Europe's Criminal Law in the Crisis of Confidence
Authors: Braum Stefan 
Published: March 2019

AbstractThe case of Carles Puigdemont underlines that European criminal law is in a crisis of confidence. The Higher Regional Court of Schleswig-Holstein has rejected a Spanish European arrest warrant for the criminal offence of rebellion because it lacks double criminality. It applied German law de lege artis without, however, questioning the European legal framework. The case would have provided an opportunity to refer the matter to the European Court of Justice for a preliminary ruling in order to further specify the European law criteria of double criminality. This would have been the adequate legal response to a politically explosive case. In the end, the Spanish judiciary sees itself disavowed and the system of the European arrest warrant called into question.
Determining the “Private Law” Nature: A Comparison Between Customary State Practice and Turkish Court Rulings
Authors: Gökçe Yasir 
Published: March 2019

AbstractThis Article uses a combination of doctrinal and comparative analyses to elucidate the most widely-used criteria according to which courts characterize an act as having a private-law nature. Further, this Article identifies the extent to which the Turkish State practice has embraced those criteria. To that end, this Article extracts two such widely-used criteria from patterns in customary State practice. In the end, the Article points out the extent to which those criteria are prevalent throughout the Turkish court rulings and concludes that Turkish caselaw is generally in alignment with the customary State practice in terms of the criteria used to determine a State act's private-law nature.
Re-Imagining the Cosmopolitan Constitution: A Comment on Alexander Somek'sThe Cosmopolitan Constitution
Authors: Dani Marco 
Published: March 2019

AbstractThis comment engages with Somek's account for the cosmopolitan constitution for two distinct purposes. It first builds on its inherent ambivalence to argue that hitherto Europe has experienced at least two different versions of the cosmopolitan constitution. Whereas in the formative period of the process of European integration, the cosmopolitan constitution manifested itself prevailingly in its more benign and democracy-enhancing political face, since the end of the 1970s it has developed a more controversial and democracy-inhibiting administrative profile. Secondly, the comment rejects as potentially regressive the proposal of redressing the biases inherent in the contemporary legal and political order by reviving the idea of a Machiavellian mixed constitution. To fulfill the promise of emancipation inspiring constitutionalism, the cosmopolitan constitution cannot segregate in separate institutions ordinary citizens and a market elite. Rather, the cosmopolitan constitution should be re-imagined with a view to reassert its original democracy-enhancing spirit and adapt it to the evolving circumstances of economic and political interdependence.
Geologic Analyses of the Causes of Morphological Variations in Lunar Craters Within the Simple‐to‐Complex Transition
Authors: Chandnani M. , Herrick R. R. , Kramer G. Y. 
Published: March 2019

AbstractThe diameter range of 15 to 20 km is within the transition from simple to complex impact craters located on the Moon. This range spans roughly a factor of 3 in impact energy for the same impactor speed, composition, and trajectory angle. We analyzed the global population of well‐preserved craters in this size range in order to assess the effects of target and impactor properties on crater shapes and morphologies. We observed that within this narrow diameter range, simple craters are confined to the highlands, and complex craters are more abundant in the mare. We found unusually deep craters around the highlands‐mare boundaries and favor the hypothesis that they form by impact cratering on high‐porosity terrain. We infer that target properties primarily contribute to the observed morphological variations in the craters. Simple crater formation is favored by a terrain that is more homogeneous in strength and topography, while transitional and complex crater formation is aided by heterogeneity in lithology, topography, or strength, or a combination of these parameters. Clearly visible impact melt deposits in a small percentage of simple craters, and two cases of craters differing in morphologies from their nearest neighbors in similar geologic settings, suggest that variation in impactor properties such as impact velocity and impactor size may have some role in causing morphological differences between similar‐sized craters.
Verification and rectification of cell type-specific splicing of a Seckel syndrome-associated ATR mutation using iPS cell model
Authors: Ichisima Jose , Suzuki Naoya M. , Samata Bumpei , Awaya Tomonari , Takahashi Jun , Hagiwara Masatoshi , Nakahata Tatsutoshi , Saito Megumu K. 
Published: March 2019

AbstractSeckel syndrome (SS) is a rare spectrum of congenital severe microcephaly and dwarfism. One SS-causative gene is Ataxia Telangiectasia and Rad3-Related Protein (ATR), and ATR (c.2101 A>G) mutation causes skipping of exon 9, resulting in a hypomorphic ATR defect. This mutation is considered the cause of an impaired response to DNA replication stress, the main function of ATR, contributing to the pathogenesis of microcephaly. However, the precise behavior and impact of this splicing defect in human neural progenitor cells (NPCs) is unclear. To address this, we established induced pluripotent stem cells (iPSCs) from fibroblasts carrying the ATR mutation and an isogenic ATR-corrected counterpart iPSC clone. SS-patient-derived iPSCs (SS-iPSCs) exhibited cell type-specific splicing; exon 9 was dominantly skipped in fibroblasts and iPSC-derived NPCs, but it was included in undifferentiated iPSCs and definitive endodermal cells. SS-iPSC-derived NPCs (SS-NPCs) showed distinct expression profiles from ATR non-mutated NPCs with negative enrichment of neuronal genesis-related gene sets. In SS-NPCs, abnormal mitotic spindles occurred more frequently than in gene-corrected counterparts, and the alignment of NPCs in the surface of the neurospheres was perturbed. Finally, we tested several splicing-modifying compounds and found that TG003, a CLK1 inhibitor, could pharmacologically rescue the exon 9 skipping in SS-NPCs. Treatment with TG003 restored the ATR kinase activity in SS-NPCs and decreased the frequency of abnormal mitotic events. In conclusion, our iPSC model revealed a novel effect of the ATR mutation in mitotic processes of NPCs and NPC-specific missplicing, accompanied by the recovery of neuronal defects using a splicing rectifier.
Integrating microsystems with metamaterials towards metadevices
Authors: Zhao Xiaoguang , Duan Guangwu , Li Aobo , Chen Chunxu , Zhang Xin 
Published: March 2019

AbstractElectromagnetic metamaterials, which are a major type of artificially engineered materials, have boosted the development of optical and photonic devices due to their unprecedented and controllable effective properties, including electric permittivity and magnetic permeability. Metamaterials consist of arrays of subwavelength unit cells, which are also known as meta-atoms. Importantly, the effective properties of metamaterials are mainly determined by the geometry of the constituting subwavelength unit cells rather than their chemical composition, enabling versatile designs of their electromagnetic properties. Recent research has mainly focused on reconfigurable, tunable, and nonlinear metamaterials towards the development of metamaterial devices, namely, metadevices, via integrating actuation mechanisms and quantum materials with meta-atoms. Microelectromechanical systems (MEMS), or microsystems, provide powerful platforms for the manipulation of the effective properties of metamaterials and the integration of abundant functions with metamaterials. In this review, we will introduce the fundamentals of metamaterials, approaches to integrate MEMS with metamaterials, functional metadevices from the synergy, and outlooks for metamaterial-enabled photonic devices.
Human colon cancer cells highly express myoferlin to maintain a fit mitochondrial network and escape p53-driven apoptosis
Authors: Rademaker Gilles , Costanza Brunella , Bellier Justine , Herfs Michael , Peiffer Raphaël , Agirman Ferman , Maloujahmoum Naïma , Habraken Yvette , Delvenne Philippe , Bellahcène Akeila , Castronovo Vincent , Peulen Olivier 
Published: March 2019

AbstractColon adenocarcinoma is the third most commonly diagnosed cancer and the second deadliest one. Metabolic reprogramming, described as an emerging hallmark of malignant cells, includes the predominant use of glycolysis to produce energy. Recent studies demonstrated that mitochondrial electron transport chain inhibitor reduced colon cancer tumour growth. Accumulating evidence show that myoferlin, a member of the ferlin family, is highly expressed in several cancer types, where it acts as a tumour promoter and participates in the metabolic rewiring towards oxidative metabolism. In this study, we showed that myoferlin expression in colon cancer lesions is associated with low patient survival and is higher than in non-tumoural adjacent tissue. Human colon cancer cells silenced for myoferlin exhibit a reduced oxidative phosphorylation activity associated with mitochondrial fission leading, ROS accumulation, decreased cell growth, and increased apoptosis. We observed the triggering of a DNA damage response culminating to a cell cycle arrest in wild-type p53 cells. The use of a p53 null cell line or a compound able to restore p53 activity (Prima-1) reverted the effects induced by myoferlin silencing, confirming the involvement of p53. The recent identification of a compound interacting with a myoferlin C2 domain and bearing anticancer potency identifies, together with our demonstration, this protein as a suitable new therapeutic target in colon cancer.
Forming global estimates of self-performance from local confidence
Authors: Rouault Marion , Dayan Peter , Fleming Stephen M. 
Published: March 2019

AbstractMetacognition, the ability to internally evaluate our own cognitive performance, is particularly useful since many real-life decisions lack immediate feedback. While most previous studies have focused on the construction of confidence at the level of single decisions, little is known about the formation of “global” self-performance estimates (SPEs) aggregated from multiple decisions. Here, we compare the formation of SPEs in the presence and absence of feedback, testing a hypothesis that local decision confidence supports the formation of SPEs when feedback is unavailable. We reveal that humans pervasively underestimate their performance in the absence of feedback, compared to a condition with full feedback, despite objective performance being unaffected. We find that fluctuations in confidence contribute to global SPEs over and above objective accuracy and reaction times. Our findings create a bridge between a computation of local confidence and global SPEs, and support a functional role for confidence in higher-order behavioral control.
Genome-wide association study in frontal fibrosing alopecia identifies four susceptibility loci including HLA-B*07:02
Authors: Tziotzios Christos , Petridis Christos , Dand Nick , Ainali Chrysanthi , Saklatvala Jake R. , Pullabhatla Venu , Onoufriadis Alexandros , Pramanik Rashida , Baudry David , Lee Sang Hyuck , Wood Kristie , Liu Lu , Seegobin Seth , Michelotti Gregory A. , Lwin Su M. , Christou Evangelos A. A. , Curtis Charles J. , de Rinaldis Emanuele , Saxena Alka , Holmes Susan , Harries Matthew , Palamaras Ioulios , Cunningham Fiona , Parkins Gregory , Kaur Manjit , Farrant Paul , McDonagh Andrew , Messenger Andrew , Jones Jennifer , Jolliffe Victoria , Ali Iaisha , Ardern-Jones Michael , Mitchell Charles , Burrows Nigel , Atkar Ravinder , Banfield Cedric , Alexandroff Anton , Champagne Caroline , Cooper Hywel L. , Vañó-Galván Sergio , Molina-Ruiz Ana Maria , Perez Nerea Ormaechea , Patel Girish K. , Macbeth Abby , Page Melanie , Bryden Alyson , Mowbray Megan , Wahie Shyamal , Armstrong Keith , Cooke Nicola , Goodfield Mark , Man Irene , de Berker David , Dunnill Giles , Takwale Anita , Rao Archana , Siah Tee-Wei , Sinclair Rodney , Wade Martin S. , Dlova Ncoza C. , Setterfield Jane , Lewis Fiona , Bhargava Kapil , Kirkpatrick Niall , Estivill Xavier , Stefanato Catherine M. , Flohr Carsten , Spector Timothy , Watt Fiona M. , Smith Catherine H. , Barker Jonathan N. , Fenton David A. , Simpson Michael A. , McGrath John A. 
Published: March 2019

AbstractFrontal fibrosing alopecia (FFA) is a recently described inflammatory and scarring type of hair loss affecting almost exclusively women. Despite a dramatic recent increase in incidence the aetiopathogenesis of FFA remains unknown. We undertake genome-wide association studies in females from a UK cohort, comprising 844 cases and 3,760 controls, a Spanish cohort of 172 cases and 385 controls, and perform statistical meta-analysis. We observe genome-wide significant association with FFA at four genomic loci: 2p22.2, 6p21.1, 8q24.22 and 15q2.1. Within the 6p21.1 locus, fine-mapping indicates that the association is driven by theHLA-B*07:02 allele. At 2p22.1, we implicate a putative causal missense variant inCYP1B1, encoding the homonymous xenobiotic- and hormone-processing enzyme. Transcriptomic analysis of affected scalp tissue highlights overrepresentation of transcripts encoding components of innate and adaptive immune response pathways. These findings provide insight into disease pathogenesis and characterise FFA as a genetically predisposed immuno-inflammatory disorder driven byHLA-B*07:02.
Analyzing machine learning models to accelerate generation of fundamental materials insights
Authors: Umehara Mitsutaro , Stein Helge S. , Guevarra Dan , Newhouse Paul F. , Boyd David A. , Gregoire John M. 
Published: March 2019

AbstractMachine learning for materials science envisions the acceleration of basic science research through automated identification of key data relationships to augment human interpretation and gain scientific understanding. A primary role of scientists is extraction of fundamental knowledge from data, and we demonstrate that this extraction can be accelerated using neural networks via analysis of the trained data model itself rather than its application as a prediction tool. Convolutional neural networks excel at modeling complex data relationships in multi-dimensional parameter spaces, such as that mapped by a combinatorial materials science experiment. Measuring a performance metric in a given materials space provides direct information about (locally) optimal materials but not the underlying materials science that gives rise to the variation in performance. By building a model that predicts performance (in this case photoelectrochemical power generation of a solar fuels photoanode) from materials parameters (in this case composition and Raman signal), subsequent analysis of gradients in the trained model reveals key data relationships that are not readily identified by human inspection or traditional statistical analyses. Human interpretation of these key relationships produces the desired fundamental understanding, demonstrating a framework in which machine learning accelerates data interpretation by leveraging the expertize of the human scientist. We also demonstrate the use of neural network gradient analysis to automate prediction of the directions in parameter space, such as the addition of specific alloying elements, that may increase performance by moving beyond the confines of existing data.
Automated measurements of greenhouse gases fluxes from tree stems and soils: magnitudes, patterns and drivers
Authors: Barba Josep , Poyatos Rafael , Vargas Rodrigo 
Published: March 2019

AbstractTree stems exchange CO2, CH4 and N2O with the atmosphere but the magnitudes, patterns and drivers of these greenhouse gas (GHG) fluxes remain poorly understood. Our understanding mainly comes from static-manual measurements, which provide limited information on the temporal variability and magnitude of these fluxes. We measured hourly CO2, CH4 and N2O fluxes at two stem heights and adjacent soils within an upland temperate forest. We analyzed diurnal and seasonal variability of fluxes and biophysical drivers (i.e., temperature, soil moisture, sap flux). Tree stems were a net source of CO2 (3.80 ± 0.18 µmol m−2 s−1; mean ± 95% CI) and CH4 (0.37 ± 0.18 nmol m−2 s−1), but a sink for N2O (−0.016 ± 0.008 nmol m−2 s−1). Time series analysis showed diurnal temporal correlations between these gases with temperature or sap flux for certain days. CO2 and CH4 showed a clear seasonal pattern explained by temperature, soil water content and sap flux. Relationships between stem, soil fluxes and their drivers suggest that CH4 for stem emissions could be partially produced belowground. High-frequency measurements demonstrate that: a) tree stems exchange GHGs with the atmosphere at multiple time scales; and b) are needed to better estimate fluxes magnitudes and understand underlying mechanisms of GHG stem emissions.
Synthesis of the extended phenacene molecules, [10]phenacene and [11]phenacene, and their performance in a field-effect transistor
Authors: Okamoto Hideki , Hamao Shino , Eguchi Ritsuko , Goto Hidenori , Takabayashi Yasuhiro , Yen Paul Yu-Hsiang , Liang Luo Uei , Chou Chia-Wei , Hoffmann Germar , Gohda Shin , Sugino Hisako , Liao Yen-Fa , Ishii Hirofumi , Kubozono Yoshihiro 
Published: March 2019

AbstractThe [10]phenacene and [11]phenacene molecules have been synthesized using a simple repetition of Wittig reactions followed by photocyclization. Sufficient amounts of [10]phenacene and [11]phenacene were obtained, and thin-film FETs using these molecules have been fabricated with SiO2 and ionic liquid gate dielectrics. These FETs operated in p-channel. The averaged measurements of field-effect mobility, <μ>, were 3.1(7) × 10−2 and 1.11(4) × 10−1 cm2 V−1 s−1, respectively, for [10]phenacene and [11]phenacene thin-film FETs with SiO2 gate dielectrics. Furthermore, [10]phenacene and [11]phenacene thin-film electric-double-layer (EDL) FETs with ionic liquid showed low-voltage p-channel FET properties, with <μ> values of 3(1) and 1(1) cm2 V−1 s−1, respectively. This study also discusses the future utility of the extremely extended π-network molecules [10]phenacene and [11]phenacene as the active layer of FET devices, based on the experimental results obtained.
Cytotoxicity profiling of deep eutectic solvents to human skin cells
Authors: Macário I. P. E. , Oliveira H. , Menezes A. C. , Ventura S. P. M. , Pereira J. L. , Gonçalves A. M. M. , Coutinho J. A. P. , Gonçalves F. J. M. 
Published: March 2019

AbstractThe tailor-made character of deep eutectic solvents (DES) turns them very attractive to be used in several applications, including in health-related areas such as pharmaceutical, nutraceutical, and cosmetic industries. However, although DES has been touted as “green” solvents, several works proved that their potential toxicity should not be neglected. Using the premise of DES applicability in the cosmetic and pharmaceutical sectors, we chose two cell lines to work as a skin model (keratinocytes HaCaT and tumor melanocytes MNT-1), to assess DES cytotoxicity. The effect of three different hydrogen bond acceptors (HBA) ([Chol]Cl, [N1111]Cl and [N4444]Cl) and three different hydrogen bond donors (HBD) (hexanoic and butanoic acid, ethylene glycol, 1-propanol and urea) were evaluated through a common viability assay (MTT assay). Results were promising since [Chol]Cl and [N1111]Cl- based DES showed good biocompatibility for the tested cells. [N4444]Cl-based DES, however, showed cytotoxicity for both cell lines, with the HBA being the driver of the toxicity. Interestingly, some compounds increased cell viability in the HaCaT cell line, namely [Chol]Cl, ethylene glycol, hexanoic acid, urea, and all [Chol]Cl and [N1111]Cl-based DES and should be considered as targets for future studies. These results highlight their possible use in cosmetic or pharmaceutical formulations.