bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identifying conserved molecular targets required for cell migration of glioblastoma cancer stem cells
Authors: Volovetz Josephine , Berezovsky Artem D. , Alban Tyler , Chen Yujun , Aranjuez George F. , Burtscher Ashley , Shibuya Kelly , Silver Daniel J. , Peterson John , Manor Danny , McDonald Jocelyn A. , Lathia Justin D. 
Published: June 2019

AbstractGlioblastoma (GBM) is the most prevalent primary malignant brain tumor and is associated with extensive tumor cell infiltration into the adjacent brain parenchyma. However, there are limited targeted therapies that address this disease hallmark. While the invasive capacity of self-renewing cancer stem cells (CSCs) and their non-CSC progeny has been investigated, the mode(s) of migration used by CSCs during invasion is currently unknown. Here we used time-lapse microscopy to evaluate the migratory behavior of CSCs, with a focus on identifying key regulators of migration. A head-to-head migration assay demonstrated that CSCs are more invasive than non-CSCs. Time-lapse live cell imaging further revealed that GBM patient-derived CSC models either migrate in a collective manner or in a single cell fashion. To uncover conserved molecular regulators responsible for collective cell invasion, we utilized the genetically tractableDrosophilaborder cell collective migration model. Candidates for functional studies were generated using results from a targetedDrosophilagenetic screen followed by gene expression analysis of the human homologs in GBM tumors and associated GBM patient prognosis. This strategy identified the highly conserved small GTPase, Rap1a, as a potential regulator of cell invasion. Alteration of Rap1a activity impaired the forward progress ofDrosophilaborder cells during development. Rap1a expression was elevated in GBM and associated with higher tumor grade. Functionally, the levels of activated Rap1a impacted CSC migration speed out of spheres onto extracellular matrix. The data presented here demonstrate that CSCs are more invasive than non-CSCs, are capable of both collective and single cell migration, and express conserved genes that are required for migration and invasion. Using this integrated approach, we identified a new role for Rap1a in the migration of GBM CSCs.
Signaling activated by nucleolar localised Notch4 Intracellular Domain underlies protection from genomic damage
Authors: Saini Neetu , Sarin Apurva 
Published: June 2019

AbstractThe assembly of signaling hierarchies and their spatiotemporal organization together, contribute to diverse signaling outcomes. This is evident in the Notch pathway, which regulates an array of cellular processes, despite a small number of core components. Here, we describe a Notch4 activated signaling cascade, dependent on the nucleolar localization of the Notch4 Intracellular Domain (NIC4), that protects cells from genotoxic damage. Localization was assessed by immune-staining for endogenous Notch4 and visualization by confocal microscopy, in breast cancer cell lines. Live-cell, imaging-based, biophysical analysis of NIC4-GFP expressing cells, indicated unhindered mobility between the nucleolus and nucleoplasm and a stable nucleolar pool of NIC4-GFP. RNAi-mediated ablations, coupled with analysis of recombinant forms of NIC4 with modifications of its nucleolar localization sequence, confirmed nucleolar localization and identified the nucleolar proteins, Nucleolin and Fibrillarin, as key intermediates in the NIC4-activated signaling cascade. The transcriptional control of ribosome biogenesis (47s and 45s pre-rRNA transcription), emerged as another unexpected consequence of the subcellular distribution of NIC4. Taken together, this study describes intrinsic features of NIC4 that confer spatial flexibility and expand the repertoire of Notch4 signaling.
Human Umbilical Cord blood monocytes, but not adult blood monocytes, rescue brain cells from hypoxic-ischemic injury: Mechanistic and therapeutic implications
Authors: Saha Arjun , Patel Sachit , Xu Li , Scotland Paula , Schwartzman Jonathan , Filiano Anthony J. , Kurtzberg Joanne , Balber Andrew E. 
Published: June 2019

AbstractCord blood (CB) mononuclear cells (MNC) are being tested in clinical trials to treat hypoxic-ischemic (HI) brain injuries. Although early results are encouraging, mechanisms underlying potential clinical benefits are not well understood. To explore these mechanisms further, we exposed mouse brain organotypic slice cultures to oxygen and glucose deprivation (OGD) and then treated the brain slices with cells from CB or adult peripheral blood (PB). We found that CB-MNCs protect neurons from OGD-induced death and reduced both microglial and astrocyte activation. PB-MNC failed to affect either outcome. The protective activities were largely mediated by factors secreted by CB-MNC, as direct cell-to-cell contact between the injured brain slices and CB cells was not essential. To determine if a specific subpopulation of CB-MNC are responsible for these protective activities, we depleted CB-MNC of various cell types and found that only removal of CB CD14+monocytes abolished neuroprotection. We also used positively selected subpopulations of CB-MNC and PB-MNC in this assay and demonstrated that purified CB-CD14+cells, but not CB-PB CD14+cells, efficiently protected neuronal cells from death and reduced glial activation following OGD. Gene expression microarray analysis demonstrated that compared to PB-CD14+monocytes, CB-CD14+monocytes over-expressed several secreted proteins with potential to protect neurons. Differential expression of five candidate effector molecules, chitinase 3-like protein-1, inhibin-A, interleukin-10, matrix metalloproteinase-9 and thrombospondin-1, were confirmed by western blotting, and immunofluorescence. These findings suggest that CD14+monocytes are a critical cell-type when treating HI with CB-MNC.
3D path planning, routing algorithms and routing protocols for unmanned air vehicles: a review
Authors: Ben Amarat Samia , Zong Peng 
Published: June 2019

Purpose
This paper aims to present a comprehensive review in major research areas of unmanned air vehicles (UAVs) navigation, i.e. three degree-of-freedom (3D) path planning, routing algorithm and routing protocols. The paper is further aimed to provide a meaningful comparison among these algorithms and methods and also intend to find the best ones for a particular application.

Design/methodology/approach
The major UAV navigation research areas are further classified into different categories based on methods and models. Each category is discussed in detail with updated research work done in that very domain. Performance evaluation criteria are defined separately for each category. Based on these criteria and research challenges, research questions are also proposed in this work and answered in discussion according to the presented literature review.

Findings
The research has found that conventional and node-based algorithms are a popular choice for path planning. Similarly, the graph-based methods are preferred for route planning and hybrid routing protocols are proved better in providing performance. The research has also found promising areas for future research directions, i.e. critical link method for UAV path planning and queuing theory as a routing algorithm for large UAV networks.

Originality/value
The proposed work is a first attempt to provide a comprehensive study on all research aspects of UAV navigation. In addition, a comparison of these methods, algorithms and techniques based on standard performance criteria is also presented the very first time.
Assessing disciplinary differences in information literacy teaching materials
Authors: Dreisiebner Stefan , Schlögl Christian 
Published: June 2019

PurposeThe purpose of this paper is to uncover similarities and differences among emphasized information literacy (IL) skills for the disciplines of political- and social sciences, economics, educational sciences, law sciences, mathematics, life sciences, history and German studies, based on an analysis of IL teaching materials.Design/methodology/approachEight issues of the German language publication seriesErfolgreich recherchieren(Succesful Research Strategies) are compared by using a structuring content analysis. The category system is based on the IL standards and performance indicators of the Association of College and Research Libraries (2000), extended with additional categories.FindingsThe results, first, suggest that the biggest similarities and differences among the disciplines are found concerning the determination of the nature and extent of the needed information, especially in the area of identifying potential sources of information. Second, some of the disciplines focus more on international sources, whereas others focus on country- and language-specific sources. Third, the criteria to define the appropriate retrieval system differ among the various disciplines. Fourth, approaches to narrow the search results differ among the various disciplines. Fifth, the critical evaluation of sources is addressed in all disciplines but relates to different contexts.Research limitations/implicationsThis approach only addresses one book per discipline out of a German language book series. Further research is needed.Originality/valueThis paper is unique in its approach and one of few papers on disciplinary differences in IL perception.
Academic achievement and mental health of left-behind children in rural China
Authors: Wang Lei , Zheng Yaojia , Li Guirong , Li Yanyan , Fang Zhenni , Abbey Cody , Rozelle Scott 
Published: June 2019

PurposeChina’s rapid pace of urbanization has resulted in millions of rural residents migrating from rural areas to urban areas for better job opportunities. Due to economic pressures and the nature of China’s demographic policies, many of these migrants have been forced to leave their children with relatives – typically paternal grandparents – at home in the countryside. Thus, while income for most migrant families has risen, a major unintended consequence of this labor movement has been the emergence of a potentially vulnerable sub-population of left-behind children (LBCs). The purpose of this paper is to examine the impacts of parental migration on both the academic performance and mental health of LBCs.Design/methodology/approachLongitudinal data were drawn from three waves of a panel survey that followed the same students and their families – including their migration behavior (i.e. whether both parents, one parent, no parent migrated) – between 2015 and 2016. The survey covers more than 33,000 students in one province of central China. The authors apply a student fixed-effects model that controls for both observable and unobservable confounding variables to explicate the causal effects of parental migration on the academic and mental health outcomes for LBC. The authors also employ these methods to test whether these effects differ by the type of migration or by gender of the child.FindingsThe authors found no overall impact of parental migration on either academic performance or mental health of LBCs, regardless of the type of migration behavior. The authors did find, however, that when the authors examined heterogeneous effects by gender (which was possible due to the large sample size), parental migration resulted in significantly higher anxiety levels for left-behind girls. The results suggest that parental migration affects left-behind boys and girls differently and that policymakers should take a more tailored approach to addressing the problems faced by LBCs.Originality/valueThe main contributions of this paper come from the large and representative sample, as well as the causal effects analysis of being left-behind on both academic performance and mental health. First, the paper uses comprehensive panel data from a representative and populous province in China, and the sample size is the largest one among LBC-related papers to the authors’ knowledge. Second, the paper separately examines the causal effects on the student outcomes of different migration strategies. Third, the paper analyzes the heterogeneous effects of different migration strategies on LBC gender. The authors believe that the paper makes a key contribution to the literature.
Data is different, and that’s why the world needs a new approach to governing cross-border data flows
Authors: Aaronson Susan Ariel 
Published: June 2019

Purpose
Companies, governments and individuals are using data to create new services such as apps, artificial intelligence (AI) and the Internet of Things (IoT). These data-driven services rely on large pools of data and a relatively unhindered flow of data across borders (few market access or governance barriers). The current approach to governing cross-border data flows through trade agreements and has not led to binding, universal or interoperable rules governing the use of data. The purpose of this article is to explain the new role of data in trade and to explain why data in trade is different from trade in other goods and services. We then suggest a new approach at the national and international levels.

Design/methodology/approach
The author uses a mixed methods approach to examine what the literature says about data as a traded good and or service, examines metaphors regarding the role of data in the economy, and then examines whether or not data is really “traded.”

Findings
Many countries do not know how to regulate data driven services. There is no consensus on what the appropriate regulatory environment looks like, nor is there a consensus on what are the barriers to cross-border data flows and what constitutes legitimate domestic regulation.

Originality/value
This is the first article to explain both the unique nature of data and the ineffectiveness of the trade system to address that distinctiveness.
Evaluating the quality of investment products: can expert judgment outsmart the market?
Authors: Šindelář Jiří , Svoboda Martin 
Published: June 2019

Purpose
This paper aims to deal with expert judgment and its predictive ability in the context of investment funds. The judgmental ratings awarder with a large set of experts was compared to a sample of the dynamic investment funds operating in Central and Eastern Europe with their objective performance, both past and future, relatively to the time of the forecast.

Design/methodology/approach
Data on the survey sample enabled the authors to evaluate both ex post judgmental validity, i.e. how the experts reflected the previous performance of funds, and ex ante predictive accuracy, i.e. how well their judgments estimated the future performance of the fund. For this purpose, logistic regression for past values estimations and linear model for future values estimations was used.

Findings
It was found that the experts (independent academicians, senior bank specialists and senior financial advisors) were only able to successfully reflect past annual returns of a five-year period, failing to reflect costs and annual volatility and, mainly, failing to predict any of the indicators on the same five-year horizon.

Practical implications
The outcomes of this paper confirm that expert judgment should be used with caution in the context of financial markets and mainly in situations when domain knowledge is applicable. Procedures incorporating judgmental evaluations, such as individual investment advice, should be thoroughly reviewed in terms of client value-added, to eliminate potential anchoring bias.

Originality/value
This paper sheds new light on the quality and nature of individual judgment produced by financial experts. These are prevalent in many situations influencing clients’ decision-making, be it financial advice or multiple product contests. As such, our findings underline the need of scepticism when these judgments are taken into account.
Nonlinear function estimation fuzzy system (NFEFS) as a novel statistical approach to estimate nanofluids’ thermal conductivity according to empirical data
Authors: Tian Zhe , Bagherzadeh Seyed Amin , Ghani Kamal , Karimipour Arash , Abdollahi Ali , Bahrami Mehrdad , Safaei Mohammad Reza 
Published: June 2019

Purpose
This paper aims to propose a new nonlinear function estimation fuzzy system as a novel statistical approach to estimate nanofluids’ thermal conductivity.

Design/methodology/approach
A fuzzy system having a product inference engine, a singleton fuzzifier, a center average defuzzifier and Gaussian membership functions is proposed for this purpose.

Findings
Results indicate that the proposed fuzzy system can predict the thermal conductivity of Al2O3/paraffin nanofluid with appropriate precision and generalization and it also outperforms the classic interpolation methods.

Originality/value
A new nonlinear function estimation fuzzy system was introduced as a novel statistical approach to estimate nanofluids’ thermal conductivity for the first time.
The impact of coaches’ ethical leadership behaviour on athletes’ voice and performance
Authors: White Stephanie , Rezania Davar 
Published: June 2019

PurposeEthics and leadership are ongoing topics in high performance sports. The purpose of this paper is to provide an insight into the relationship between coaches’ ethical leadership behaviour, as perceived by athletes, and its impact on student-athlete accountability, voice and performance.Design/methodology/approachThe paper examines the constructs of coaches’ ethical leadership behaviour, felt accountability and voice behaviour. The authors surveyed student-athletes from a variety of sports who compete in the Ontario University Athletics Regional Association. A total of 303 respondents (n=303) completed the survey. Partial least squares path modelling algorithm was utilised for testing hypotheses.FindingsThe results of the study indicate a significant relationship between a coach exhibiting ethical leadership behaviour and student-athlete voice behaviour and performance. Felt accountability mediates the effect of ethical leadership on voice and performance.Practical implicationsThis study provides support for the hypothesis that coaches who behave ethically and whose actions represent their words create an environment where a student-athlete feels accountable. This is a powerful concept as it can positively impact individual and team success. The findings suggest that one of the ways that coaches can impact athletes’ performance is to demonstrate and model ethical conduct, and reward ethical acts.Originality/valueThe paper examines how coaches’ ethical behaviour might impact individual processes of accountability, voice and performance. Second, the paper uses the construct of accountability to explain how coaches’ ethical leadership impacts student-athlete behaviour. The accountability literature indicates that followers’ behaviours can be understood as the consequences of his/her perceived accountability towards the leader.
Light‐level geolocator analyses: A user's guide
Authors: Lisovski Simeon , Bauer Silke , Briedis Martins , Davidson Sarah C. , Dhanjal‐Adams Kiran L. , Hallworth Michael T. , Karagicheva Julia , Meier Christoph M. , Merkel Benjamin , Ouwehand Janne , Pedersen Lykke , Rakhimberdiev Eldar , Roberto‐Charron Amélie , Seavy Nathaniel E. , Sumner Michael D. , Taylor Caz M. , Wotherspoon Simon J. , Bridge Eli S. 
Published: June 2019

Abstract

Light‐level geolocator tags use ambient light recordings to estimate the whereabouts of an individual over the time it carried the device. Over the past decade, these tags have emerged as an important tool and have been used extensively for tracking animal migrations, most commonly small birds.

Analysing geolocator data can be daunting to new and experienced scientists alike. Over the past decades, several methods with fundamental differences in the analytical approach have been developed to cope with the various caveats and the often complicated data.

Here, we explain the concepts behind the analyses of geolocator data and provide a practical guide for the common steps encompassing most analyses – annotation of twilights, calibration, estimating and refining locations, and extraction of movement patterns – describing good practices and common pitfalls for each step.

We discuss criteria for deciding whether or not geolocators can answer proposed research questions, provide guidance in choosing an appropriate analysis method and introduce key features of the newest open‐source analysis tools.

We provide advice for how to interpret and report results, highlighting parameters that should be reported in publications and included in data archiving.

Finally, we introduce a comprehensive supplementary online manual that applies the concepts to several datasets, demonstrates the use of open‐source analysis tools with step‐by‐step instructions and code and details our recommendations for interpreting, reporting and archiving.
Understanding cultural omnivores: social and political attitudes
Authors: Chan Tak Wing 
Published: June 2019

AbstractIn this paper, I use data from the British Household Panel Survey and Understanding Society to investigate the social and political attitudes of cultural omnivores. I report a threefold typology of cultural consumption in the domains of music and visual arts that is consistent with previous research. Then by linking data across the two panel surveys, I show that cultural omnivores have quite a distinctive profile of social attitudes. Specifically, omnivores are more trusting and risk‐taking. They hold more favourable views about the European Union, and they tend to eschew subnational identities. Omnivores are politically more engaged. But they are not more ‘class conscious’, nor are they particularly left‐wing or right‐wing on distributional issues. When asked what is important to the sense of who they are, the two most important status‐conferring attributes, that is, profession and education, are not more salient to omnivores than to others. But omnivores are more extravert and open to new experiences. Taken together, these results suggest that omnivorousness is an expression of cosmopolitan postmaterialism rather than a new form of distinction.
From ‘having’ to ‘being’: self‐worth and the current crisis of American society
Authors: Lamont Michèle 
Published: June 2019

AbstractWith growing inequality, the American dream is becoming less effective as a collective myth. With its focus on material success, competition and self‐reliance, the intensified diffusion of neoliberal scripts of the self is leading the upper‐middle class toward a mental health crisis while the working class and low‐income groups do not have the resources needed to live the dream. African Americans, Latinos and undocumented immigrants, who are presumed to lack self‐reliance, face more rigid boundaries. One possible way forward is broadening cultural membership by promoting new narratives of hope centered on a plurality of criteria of worth, ‘ordinary universalism’ and destigmatizing stigmatized groups.