bluuebunny/crossref_metadata_2025_split huggingface dataset:
Advanced Glycation End Products (AGEs), Receptor for AGEs, Diabetes, and Bone: Review of the Literature
Authors: Asadipooya Kamyar , Uy Edilfavia Mae 
Published: July 2019

AbstractDiabetes compromises bone cell metabolism and function, resulting in increased risk of fragility fracture. Advanced glycation end products (AGEs) interact with the receptor for AGEs (RAGE) and can make a meaningful contribution to bone cell metabolism and/or alter function. Searches in PubMed using the key words “advanced glycation end-product,” “RAGE,” “sRAGE,” “bone,” and “diabetes” were made to explain some of the clinical outcomes of diabetes in bone metabolism through the AGE–RAGE signaling pathway. All published clinical studies were included in tables. The AGE–RAGE signaling pathway participates in diabetic complications, including diabetic osteopathy. Some clinical results in diabetic patients, such as reduced bone density, suppressed bone turnover markers, and bone quality impairment, could be potentially due to AGE–RAGE signaling consequences. However, the AGE–RAGE signaling pathway has some helpful roles in the bone, including an increase in osteogenic function. Soluble RAGE (sRAGE), as a ligand decoy, may increase in either conditions of RAGE production or destruction, and then it cannot always reflect the AGE–RAGE signaling. Recombinant sRAGE can block the AGE–RAGE signaling pathway but is associated with some limitations, such as accessibility to AGEs, an increase in other RAGE ligands, and a long half-life (24 hours), which is associated with losing the beneficial effect of AGE/RAGE. As a result, sRAGE is not a helpful marker to assess activity of the RAGE signaling pathway. The recombinant sRAGE cannot be translated into clinical practice due to its limitations.
DrosophilaMon1 constitutes a novel node in the brain-gonad axis that is essential for female germline maturation
Authors: Dhiman Neena , Shweta Kumari , Tendulkar Shweta , Deshpande Girish , Ratnaparkhi Girish S. , Ratnaparkhi Anuradha 
Published: July 2019

ABSTRACTMonensin-sensitive 1 (Mon1) is an endocytic regulator that participates in the conversion of Rab5-positive early endosomes to Rab7-positive late endosomes. In Drosophila, loss of mon1 leads to sterility as the mon1 mutant females have extremely small ovaries with complete absence of late stage egg chambers – a phenotype reminiscent of mutations in the insulin pathway genes. Here, we show that expression of many Drosophila insulin-like peptides (ILPs) is reduced in mon1 mutants and feeding mon1 adults an insulin-rich diet can rescue the ovarian defects. Surprisingly, however, mon1 functions in the tyramine/octopaminergic neurons (OPNs) and not in the ovaries or the insulin-producing cells (IPCs). Consistently, knockdown of mon1 in only the OPNs is sufficient to mimic the ovarian phenotype, while expression of the gene in the OPNs alone can ‘rescue’ the mutant defect. Last, we have identified ilp3 and ilp5 as critical targets of mon1. This study thus identifies mon1 as a novel molecular player in the brain-gonad axis and underscores the significance of inter-organ systemic communication during development.
CXCL2 attenuates osteoblast differentiation by inhibiting the ERK1/2 signaling pathway
Authors: Yang Yang , Zhou Xinying , Li Yuejun , Chen Ajuan , Liang Wenquan , Liang Guojun , Huang Bin , Li Qingchu , Jin Dadi 
Published: July 2019

ABSTRACT
The C-X-C motif chemokine ligand 2 (CXCL2), a member of the CXC receptor ligand family, is involved in various immune and inflammatory processes, but its effect(s) on bone formation have not yet been reported. We report here that CXCL2 is enriched in bone marrow and show abundant expression of CXCL2 in osteoblasts of osteoporotic mice. CXCL2 neutralization within the bone marrow by using antibody alleviated bone loss in mice, indicating a negative role of CXCL2 in bone formation. In line with this, CXCL2 overexpression attenuated proliferation, as well as differentiation, of osteoblasts in vitro. By contrast, CXCL2 downregulation promoted osteoblast expansion and differentiation. Mechanistically, CXCL2 inhibits the ERK1/2 (MAPK3/1) signaling pathway in osteoblasts. Activation of ERK1/2 abolishes the inhibitory effect of CXCL2 in osteoblasts, whereas inactivation of ERK1/2 reverses the osteogenic role of CXCL2 inhibition. These results show that CXCL2 attenuates osteoblast differentiation through inhibition of the ERK1/2 signaling pathway. We demonstrate here that CXCL2 is a negative regulator of bone formation and clarify the responsible mechanisms. Therefore, pharmaceutical coordination of CXCL2 and of the pathways through which it is regulated in osteoblasts might be beneficial regarding bone formation.
Sociodemographic and clinical profile of patients with dual diagnosis living in Warsaw district Mokotow in comparison with participants in other European countries- results of the international, multicentre research project ISADORA.
Authors: Charzyńska Katarzyna , Sawicka Maryla , Osuchowska- Kościjańska Anna , Chądzyńska Małgorzata , Giguere Marta , Kasperek- Zimowska Beata , Bronowski Paweł 
Published: July 2019

CelCelem obecnego badania było porównanie profilu społeczno- demograficznego i klinicznego pacjentów z podwójną diagnozą leczonych w Warszawie z profilem pacjentów leczonych w innych ośrodkach w Europie.MetodaDo badania w Warszawie zakwalifikowano 50 kolejno przyjmowanych pacjentów, w całym programie badawczym uczestniczyło 352 pacjentów z 7 ośrodków w Europie. Rekrutacja odbywała się na całodobowych oddziałach ogólnopsychiatrycznych oraz całodobowych oddziałach leczenia podwójnych diagnoz. Dane zostały zebrane w trakcie jednorazowego wywiadu przy wykorzystaniu kwestionariuszy M.I.N.I i EuropAsi.WynikiZarówno w Warszawie, jak i w całej badanej populacji mężczyźni stanowili blisko 2/3 grupy. Pacjenci badani w Warszawie częściej mieszkali z bliskimi i pozostawali w trwałych związkach niż badani w innych ośrodkach. Zaburzenia depresyjne były najczęstszą diagnozą w grupie pacjentów leczonych w Warszawie i były rozpoznawane istotnie częściej, niż miało to miejsce w Tampere. Ponadto w tej grupie istotnie rzadziej, w porównaniu do pacjentów badanych w pozostałych ośrodkach, rozpoznawano nadużywanie przetworów konopi, a istotnie częściej- nadużywanie leków uspokajających.WnioskiRóżnice między ośrodkami dotyczące profilów społeczno- demograficznych i klinicznych pacjentów z podwójną diagnozą wynikały zarówno z uwarunkowań społeczno- kulturowych (np. dostępność substancji), jak i przyjętej metodologii badania.
Effectiveness of ketamine in depressed patients resistant to ECT or rTMS therapy.
Authors: Gosek Paweł , Chojnacka Magdalena , Święcicki Łukasz , Bieńkowski Przemysław 
Published: July 2019

CelW ostatnich latach opublikowano wiele opisów dotyczących możliwości uzyskania szybkiej i istotnej klinicznie poprawy stanu psychicznego u pacjentów z rozpoznaniem depresji po podaniu antagonisty receptorów N-metylo-D-asparaginowych (NMDA) - ketaminy. Większość badań dotyczy podania ketaminy pacjentom z depresją lekooporną, co jednak nie oznaczało oporności na leczenie elektrowstrząsowe. W niniejszej pracy prezentujemy serię 5 przypadków pacjentów opornych na różne metody leczenia biologicznego (w tym leczenie farmakologiczne, EW, rTMS) u których w warunkach naturalistycznych zastosowano ketaminę w subanestetycznej dawce 0,5 mg/kg. Zgodnie z wiedzą autorów tej pracy jest to pierwszy opisany przypadek leczenia ketaminą u pacjenta z depresją oporną na leczenie farmakologiczne i rTMS.MetodaW opisanej grupie u dwóch pacjentów rozpoznano depresję nawracającą, u jednego chorobę afektywną dwubiegunową, u dwóch kolejnych ciężki epizod depresji. Skuteczność i możliwe działania niepożądane monitorowano przy użyciu skal psychometrycznych, podobnie podstawowe parametry życiowe oraz zapis EKG w czasie wlewów ketaminy.WynikiW opisywanej grupie obserwowano przejściową poprawą stanu psychicznego, lecz efektywność leczenia była istotnie mniejsza niż wynikałoby to z dotychczasowych doniesień. Obserwowano dobrą tolerancję, przejściowe wahania ciśnienia tętniczego oraz przejściowe występowanie łagodnych objawów dysocjacyjnych. Nie w pełni satysfakcjonujące wyniki kuracji ketaminą mogą być związane z opornością na wcześniejsze próby leczenia biologicznego, współwystępowaniem objawów lęku i somatyzacji, lub heterogennością opisywanej grupy.WnioskiPrezentowane wyniki nie przemawiają za stosowaniem ketaminy w monoterapii w grupie pacjentów z depresją oporną na leczenie biologiczne
Methods of applying traction to unerupted maxillary incisors and safety considerations
Authors: Parker Kate , Acharya Priti , Collins Joanne M 
Published: July 2019

Unerupted maxillary incisors should be identified and managed promptly. When exposure and bonding of a gold chain to an unerupted tooth is indicated, there are multiple methods that can be used to apply traction to the tooth. This paper outlines the different methods available, their advantages and disadvantages and the important safety considerations. Treatment often utilizes small components which may pose an inhalation or ingestion risk if not used appropriately. CPD/Clinical Relevance: This article reviews the different methods available to align impacted upper incisors. It details the advantages and disadvantages of each method and highlights the associated safety considerations.
Nasal considerations with the Le Fort I osteotomy
Authors: McSwiney Timothy , Khan Sadaf , Dhariwal Daljit 
Published: July 2019

Orthognathic surgery involves the correction of severe dentofacial deformities through a combination of orthodontics, surgery and, occasionally, restorative dentistry. This procedure, when involving surgical movement of the maxilla, can lead to changes in the overlying nasal morphology. In this paper, the standard nasal assessment that is undertaken prior to a Le Fort I osteotomy is outlined along with the reported nasal changes seen following this procedure. In addition, the various risk factors associated with adverse nasal changes are considered, as are the management techniques adopted by clinicians to minimize these changes CPD/Clinical Relevance: Clinicians should be aware of the adverse nasal changes associated with the Le Fort I osteotomy.
The Appomattox Field: Norphlet Aeolian Sand Dune Reservoirs in the Deep-Water Gulf of Mexico
Authors: Godo Ted 
Published: July 2019

ABSTRACT
Exploration for oil in the Norphlet reservoir in the deep-water Gulf of Mexico began in 2003 at prospect Shiloh (DC269). The well found oil but not an economic volume. The second prospect, Vicksburg (DC353), was drilled in 2007. This well found a larger in-place volume of oil, but with an immovable solid hydrocarbon component within pore spaces, there was great uncertainty as to the potential producible volumes. Two subsequent wells (Fredericksburg [DC486] and Antietam [DC268]) were dry and had a very small amount of oil, respectively. Finally, in late 2009, the fifth well (Appomattox [MC392]) was a significant discovery of high-quality oil in a thick aeolian Norphlet sandstone.
Perla Field: The Largest Discovery Ever in Latin America
Authors: Castillo Veronica , Benkovics Laszlo , Cobos Carlos , Demuro Daniel , Franco Alejandro 
Published: July 2019

ABSTRACT
Perla gas field is a world-class giant and one of the most significant in Latin America in the last decade. The field was discovered in August 2009. It is the largest gas field in Latin America with approximately 17 trillion cubic feet (tcf) of gas in place, or 3.1 BBOE. The field, located in the shallow waters of the Gulf of Venezuela, was discovered, and is operated by Cardon IV S.A., a 50/50 joint operating company formed by Repsol and Eni.
The Perla discovery is important because it is a Play opener for the southern Caribbean domain, triggering a new exploration cycle in the region and proving a previously unknown Tertiary thermogenic petroleum system. The discovery well encountered a thick carbonate section (240 m [787 ft] thick) with excellent primary reservoir properties. The trap is a combination structural and stratigraphic, defined by a northwest–southeast trending asymmetric faulted structure and pinch-out of the carbonate reservoir rock to the north. The proven hydrocarbon column exceeds 350 m (1148 ft) and is in complete hydraulic continuity, and the structural-stratigraphic closure exceeds 100 km2 (39 mi2).
Breaking Barriers and Paradigms in Presalt Exploration: The Pão de Açúcar Discovery (Offshore Brazil)
Authors: de Luca Pedro Henrique Vieira , Matias Hugo , Carballo José , Sineva Diana , Pimentel Gustavo Antunes , Tritlla Jordi , Esteban Mateu , Loma Rubén , Alonso José Luis Algibez , Jiménez Ricardo Perona , Pontet Matthieu , Martinez Pedro Bonillo , Vega Victor 
Published: July 2019

ABSTRACT
Pão de Açúcar is certainly one of the most impressive and challenging hydrocarbon accumulations found in the prolific Campos Basin, offshore Brazil. This discovery opened a new frontier for exploration in Brazil’s ultradeep waters, in depths ranging from 2500 to 2900 m (8202 to 9514 ft). Pão de Açúcar is the third discovery made by a consortium integrated by Repsol Sinopec Brasil (operator), Statoil do Brasil, and Petrobras in the Concession BM-C-33, with estimated resources of 700 million bbl of light oil and 3 tcf of gas. This discovery is the result of the integrated work of a multidisciplinary international team using some of the most advanced technologies available today in the oil exploration industry in seismic imaging, drilling, formation evaluation, and fluid-rock sampling analysis. This discovery consists of a significant hydrocarbon column hosted within a unique reservoir made up of a variety of basic volcanic rocks overlain by pervasively silicified microbial carbonate platform/ramps, grading toward profundal lake facies. This chapter summarizes the main results of the exploration and ongoing appraisal work regarding this unique hydrocarbon accumulation, highlighting both the complexity of the discovered reservoirs and the operational and technical challenges faced, and still to overcome, before beginning production.
The Jubilee Field, Ghana: Opening the Late Cretaceous Play in the West African Transform Margin
Authors: Dailly Paul , Henderson Tracey , Kanschat Kathy , Lowry Phil , Sills Stephen 
Published: July 2019

ABSTRACT
The discovery of the Jubilee field in the Tano Basin of Ghana opened a new play in the deep water of the Atlantic transform margins. The field is a late Cretaceous combination structural-stratigraphic trap associated with topography created by the transform tectonics during the opening of the Atlantic. Prior to the drilling of the discovery well, the African transform margin had seen very little deep-water exploration with only nine wells drilled over a margin more than 2000 km (1243 mi) long. The field was discovered in June 2007 with the Mahogany 1 well, which encountered 98 m (322 ft) of high-quality oil pay in a Turonian-aged fan sequence trapped in a combination structural-stratigraphic trap. Subsequent to the discovery, accelerated appraisal and phased development resulted in first production in November 2010. The field is currently producing more than 100,000 BOPD and has a planned peak production of 120,000 BOPD. The discovery has resulted in an industry-wide exploration campaign of over 50 wells in the last 8 years. These have resulted in a number of additional discoveries and to date at least one additional development. This chapter describes the exploration play concept and the geology of the field.
The Windjammer Discovery: Play Opener for Offshore Mozambique and East Africa
Authors: Fletcher Tom 
Published: July 2019

ABSTRACT
The Windjammer prospect spud in late 2009, leading to the discovery of 190 trillion cubic feet (tcf) in the offshore region of the Rovuma Basin in northern Mozambique. The key reservoirs are composed of stacked submarine fan complexes from the Oligocene, Eocene, and Paleocene epochs of the lower Tertiary. The submarine fans form traps truncating against the leading edge of the Palma fold and thrust belt. The high-permeability reservoirs are thick, widespread, and very well connected, making them ideally suited for long-term natural gas production and liquid natural gas (LNG) exports. The massive amount of gas found offshore Rovuma has the potential to elevate Mozambique to the world’s third-largest exporter of natural gas.
The Jansz-Io Gas Field, Northwest Shelf Australia: A Giant Stratigraphic Trap
Authors: Jenkins C. C. , Duckett A. , Boyett B. A. , Glenton P. N. , Mills A. A. , Schapper M. C. , Williams M. A. , McPherson J. G. 
Published: July 2019

ABSTRACT
The Jansz-Io gas field is located in production licenses WA-36-L, WA-39-L, and WA-40-L within the Carnarvon Basin, northwest shelf, Australia. It is 70 km (43 mi) northwest of the Gorgon gas field, 140 km (87 mi) northwest of Barrow Island, and 250 km (155 mi) from Dampier on the northwest coast of Western Australia. Water depths vary from 1200 to 1400 m (3937 to 4593 ft) across the field.
The Jansz-Io gas field was discovered in 2000 by the Jansz-1 exploration well. A three-dimensional (3-D) seismic survey was acquired in 2004, and a further five wells were drilled between 2000 and 2009 to further delineate the field extent and size and characterize the resource to facilitate progress toward development.
The Jansz-Io hydrocarbon trap extends over 2000 km2 (772 mi2) with both structural (faulted anticline) and stratigraphic (reservoir pinch-out) components. The stratigraphic component of the trap is defined by the reservoir extent, which is limited by depositional downlap to the northwest, and erosional truncation by Upper Jurassic and Lower Cretaceous unconformities to the southeast.
The reservoir comprises muddy, bioturbated, predominantly very fine- to fine-grained sandstones deposited in a shallow-marine environment and is divided into two units. The upper wedge reservoir has 25 to 35% total porosity with 10 to 1000 md permeability, and the lower wedge reservoir has 15 to 25% porosity with 0.01 to 10 md permeability. Both reservoir units are expected to contribute gas during production.
The original gas in place (OGIP) for the Jansz-Io Oxfordian reservoir has a probabilistic range from 320 to 946 Gm3 (11 to 33 tcf), with a P50 value of 632 Gm3 (22 tcf). The ultimate recovered gas for the field will depend on both the development plan and the reservoir performance over field life. For the current 15-well development plan, the resource estimates range from 201 to 442 Gm3 (7 to 16 tcf).
The Jansz-Io gas field is a key part of the greater Gorgon liquified natural gas (LNG) project and will supply gas to the LNG plant that is being constructed on Barrow Island. The development concept includes subsea completions from three drill centers placed on the seafloor connected to a subsea production pipeline to carry gas to the LNG processing plant.
For the first stage of field development, 10 development wells were successfully drilled and completed during 2012 and 2014. The second drilling campaign is planned to commence after field start-up with the timing dependant on field performance.
Einführung in die fraktionale Flussschätzung in elektromagnetischen Aktoren
Authors: Seifert Robert , Steiert Christoph , Hofmann Wilfried , Röbenack Klaus 
Published: July 2019

Zusammenfassung
In diesem Artikel wird erstmalig ein neuartiger fraktionaler Flussschätzer vorgestellt, der das atypische Übertragungsverhalten zwischen dem messbaren Aktorstrom und der kraftproportialen Flussdichte über eine große Bandbreite mit hoher Genauigkeit abbilden kann. Am Beispiel einer Ringkernspule wird die gesamte Vorgehensweise von der Modellbildung über dessen Approximation und Diskretisierung bis zur hardwareseitigen Implementierung nachvollzogen. Die abschließenden Messungen zeigen das große Potential einer schätzerbasierten Flussdichteregelung für hochdynamische Aktoren und Magnetlager.
The use of LEGO Mindstorms to create a model of the surgical robot arm for the education of medical students
Authors: Rudnik Michał , Walecki Piotr Krzysztof 
Published: July 2019

Abstract
The aim of the work is to assess the use of LEGO-based robotics in the education of medical students. Training on specialized robotic surgery simulators is available only to a small group of specialists. The LEGO Mindstorms was used to create a model of the surgical robot arm. The model is controlled by a specially prepared panel created in the LabVIEW. The functionality of the model of a surgical robot arm allows people who have not been using these robots to become familiar with the basics of their operation. Medical students using the arm will be able to observe structural problems: the stiffness of construction, or its utility, the range of movements and its limitations, motion and force control using different robotic manipulators. The use of a modular computer programming language and a modular building platform problem in LEGO Education contributes to the development of critical thinking and problem solving, and these skills are useful to physicians during their work.
Dynamics of female labor force participation and welfare with multiple social reference groups
Authors: Pintea Mihaela 
Published: July 2019

Abstract
I develop a model with status concerns to analyze how different economic factors affect female labor participation and welfare, as well as average household incomes and wages. Reductions in the price of domestic goods and increases in female wages have positive effects on female participation. Increases in male wages have different effects on female participation depending on whether they affect female wages or not. Events that lead to increases in female participation are usually associated with decreases in the welfare of stay-at-home wives but are not necessarily associated with increases in welfare of working wives. Allowing for part-time work can lead to an increase in overall female labor force participation, but some women that would have worked full-time end up working part-time. If female wages are endogenous, an increase in male wages leads to an increase in the female participation rate even if it is not associated with a decrease in the gender wage gap. The positive feedback of increased female participation on their wages can lead to hysteresis of dual equilibria of high and low female labor force participation and a discontinuous transition between these equilibria.
Bioenergetics and translational metabolism: implications for genetics, physiology and precision medicine
Authors: Hill Bradford G. , Shiva Sruti , Ballinger Scott , Zhang Jianhua , Darley-Usmar Victor M. 
Published: July 2019

Abstract
It is now becoming clear that human metabolism is extremely plastic and varies substantially between healthy individuals. Understanding the biochemistry that underlies this physiology will enable personalized clinical interventions related to metabolism. Mitochondrial quality control and the detailed mechanisms of mitochondrial energy generation are central to understanding susceptibility to pathologies associated with aging including cancer, cardiac and neurodegenerative diseases. A precision medicine approach is also needed to evaluate the impact of exercise or caloric restriction on health. In this review, we discuss how technical advances in assessing mitochondrial genetics, cellular bioenergetics and metabolomics offer new insights into developing metabolism-based clinical tests and metabolotherapies. We discuss informatics approaches, which can define the bioenergetic-metabolite interactome and how this can help define healthy energetics. We propose that a personalized medicine approach that integrates metabolism and bioenergetics with physiologic parameters is central for understanding the pathophysiology of diseases with a metabolic etiology. New approaches that measure energetics and metabolomics from cells isolated from human blood or tissues can be of diagnostic and prognostic value to precision medicine. This is particularly significant with the development of new metabolotherapies, such as mitochondrial transplantation, which could help treat complex metabolic diseases.