bluuebunny/crossref_metadata_2025_split huggingface dataset:
Longitudinal Trends and Variation in Antipsychotic Use in Older Adults After Cardiac Surgery
Authors: Kim Dae Hyun , Mahesri Mufaddal , Bateman Brian T. , Huybrechts Krista F. , Inouye Sharon K. , Marcantonio Edward R. , Herzig Shoshana J. , Ely E. Wesley , Pisani Margaret A. , Levin Raisa , Avorn Jerry 
Published: August 2018

ObjectivesTo evaluate temporal trends and between‐hospital variation in off‐label antipsychotic medication (APM) use in older adults undergoing cardiac surgery.DesignRetrospective cohort study.SettingNational administrative database including 465 U.S. hospitals.ParticipantsIndividuals aged 65 and older without known indications for APMs who underwent cardiac surgery from 2004 to 2014 (N=293,212).MeasurementsPostoperative exposure to any APMs and potentially excessive dosing were examined. Hospital‐level APM prescribing intensity was defined as the proportion of individuals newly treated with APMs in the postoperative period.ResultsThe rate of APM use declined from 8.8% in 2004 to 6.2% in 2014 (p<.001). Use of haloperidol (parenteral 7.0% to 4.5%, p<.001; oral: 1.9% to 0.5%, p<.001), and risperidone (1.1% to 0.3%, p<.001) declined, whereas quetiapine use tripled (0.6% to 1.9%, p=.03). Hospital APM prescribing intensity varied widely, from 0.3% to 35.6%, across 465 hospitals. Treated individuals at higher‐prescribing hospitals were more likely to receive APMs on the day of discharge (highest vs lowest quintile: 15.1% vs 9.6%; p<.001) and for a longer duration (4.8 vs 3.7 days; p<.001) than those at lower‐prescribing hospitals. Delirium was the strongest risk factor for APM exposure (odds ratio=9.73, 95% confidence interval=9.02–10.5), whereas none of the hospital characteristics were significantly associated. The rate of potentially excessive dosing declined (60.7% to 44.9%, p<.001), and risk factors for potentially excessive dosing were similar to those for any APM exposure.ConclusionsOur findings suggest highly variable prescribing cultures and raise concerns about inappropriate use, highlighting the need for better evidence to guide APM prescribing in hospitalized older adults after cardiac surgery.
Facial angiofibromas treated by rapamycin 0.05% ointment and a combined laser therapy
Authors: Negosanti Francesca , Tengattini Vera , Gurioli Carlotta , Neri Iria 
Published: August 2018

SummaryBackgroundTuberous sclerosis is an autosomal dominant genodermatosis characterized by nonmalignant hamartomas in multiple organs. Facial angiofibromas are most commonly located on the face and have the potential to cause disfigurement. Facial disfigurement negatively affects the quality of life of patients and their families, often leading to negative psychosocial outcomes. Nowadays there are no treatment guidelines for facial angiofibromas but due to the progressive nature of facial angiofibromas a safe technique offering good results is needed.Objective and ResultsWe report the case of a 40‐year‐old female affected by tuberous sclerosis, whose facial angiofibromas were satisfactorily treated by rapamycin 0.05% ointment, and a combined laser therapy.
Pathomorphological criteria of use efficiency of resorbable and permanent implants in aesthetic medicine and cosmetic dermatology
Authors: Turkevych Marta , Turkevych Alexander , Kadjaya Albina , Gold Michael H. , Lotti Torello , Sulamanidze George 
Published: August 2018

SummaryBackgroundThe use of threads in aesthetic medicine is based on its ability to stimulate collagen production, which is claimed by the manufacturers, but this information has no basis at all, as no research has been carried out that would confirm the claimed information.AimsTo determine effectiveness of collagenogenesis as a result of setting of resorbing and permanent implants on the basis of study pathomorphological changes in the skin.MethodsThe studies were performed on 30 mature white male rats which were divided into two groups depending on the type of implanted threads.ResultsDependence between type of implantation thread (structure) and stimulation of collagenogenesis has been established.ConclusionsWhile studying morphological changes in the peri‐implant zone, it was found that in all groups of experimental rats, collagen with different term of biodegradation and in different quantities on various chronological stages is formed. It was established that collagenogenesis is stimulated unevenly, depending on the type of implantation thread (chemical composition and structure). On the 90th day of the experiment, the resorbing thread did not completely degrade, which does not contradict the information provided by the manufacturer about the period of disintegration (365 days), and the expediency of using these cosmetic threads in aesthetic dermatology for the purpose of prolonged lifting skin correction. The specificity of the structure of implant threads, namely, the form of a spring (AS), as a provocative factor for long‐term alteration, causes long‐term inflammatory response in tissues (90th day of the experiment).
Serum levels of human epididymis protein 4 are more stable than cancer antigen 125 in early and mid‐term pregnancy
Authors: Wang Zhiheng , Zhou Fangfang , Xiao Xirong , Ying Chunmei 
Published: August 2018

AbstractAimPrevious studies have shown serum human epididymis protein 4 (HE4) and cancer antigen 125 (CA125) levels could serve as predictive markers in the diagnosis of ovarian cancer. However, HE4 levels have been less well studied during pregnancy, especially in threatened abortion, while CA125 levels were fluctuated. Our study aimed to assess the stability of HE4 and CA125 levels through trimesters and in cases of threatened abortion.MethodsForty‐six nonpregnant women (control), 167 healthy pregnant women and 46 pregnant threatened abortion (TA; 8–12 weeks pregnancy) women who visited the Obstetrics and Gynecology Hospital of Fudan University from September to December 2017 were recruited. The healthy pregnant women group included 57 women in the first trimester (T1), 55 in the second (T2) and 55 in the third (T3). Serum levels of HE4 and CA125 were measured by electrochemiluminescent immunoassay.ResultsBoth HE4 and CA125 levels in the T3 group were significantly higher than in the control group (P < 0.001). There was no difference in HE4 between the control, T1 and T2 groups, while levels of CA125 in T1 group were elevated (P < 0.001). There was no difference in HE4 levels between the TA, control and T1 groups. However, the levels of CA125 in the TA group were much higher (P < 0.05).ConclusionThe level of HE4 was found to be more stable than that of CA125 in early and mid‐pregnancy and in cases of threatened abortion.
A nationwide survey on gynecologic endoscopic surgery in Japan, 2014–2016
Authors: Taniguchi Fuminori , Wada‐Hiraike Osamu , Hirata Tetsuya , Tajima Hiroto , Masuda Hirotaka , Kitade Mari , Kumakiri Jun , Uchiide Ichiro , Saito Juichiro , Kurose Keisuke , Takeshita Toshiyuki , Harada Tasuku ,   on behalf of the Surgical Outcome Research Committee in Japan Society of Gynecologic and Obstetric Endoscopy and Minimally Invasive Therapy (JSGOE)
Published: August 2018

AbstractAimSince 2014, Japan Society of Gynecologic and Obstetric Endoscopy and minimally invasive therapy (JSGOE) conducted a nationwide survey on gynecologic endoscopic surgery. We aimed to evaluate the current status and complications associated with endoscopic surgery by Japan gynecologic and obstetric endoscopy‐database registry system (JOE‐D).MethodsElectrical medical records concerning the endoscopic surgery were generated from the daily use of reporting system. The subjects were all patients who underwent gynecologic endoscopic surgery. In addition to assessment of actual numbers, diagnosis, and operative methods, adverse events were registered.ResultsTotal 203 970 patients performed laparoscopic, hysteroscopic and falloposcopic surgery for 3 years, 2014–2016. The numbers of endoscopic surgeries conducted in 2016 were increased more than 67 000, 13 000 or 450 cases, respectively. Incidence rates of complications involving these three types of surgeries in each year were approximately 3.1%. Incidences of intraoperative complications were relatively high in malignant diseases, laparoscopic‐assisted vaginal hysterectomy (LAVH) and myomectomy (LAM). In total laparoscopic hysterectomy/laparoscopic hysterectomy (TLH/LH) performed from 2014 to 2016, ureteral injury as intra and postoperative complication occurred in 0.35%. In the past 3 years, the rates of vascular injury, urinary tract, and bowel injury as intraoperative complications caused by laparoscopic surgery were approximately 0.1%. In the hysteroscopic surgery, the rates of total intra‐ and postoperative complications were 0.78%.ConclusionWe exhibited the current status by the nationwide survey of gynecologic endoscopic surgery all over Japan. Severe intra or postoperative complications were identified over the 3 years at a rate of 0.04%.
Primary breast cancer of the vulva: A case report and literature review
Authors: Al‐Mansouri Loma , Poursoltan Pirooz , Simons Mary , Muljono Anita , Boyages John 
Published: August 2018

AbstractAn elderly lady presented with a 2‐year history of intermittent vaginal bleeding and later the development of a vulvovaginal mass. A core biopsy histology specimen from the mass and the left inguinal lymph node was suggestive of metastatic adenocarcinoma of breast origin. No breast lesion was detected on mammography, and axillary nodes were negative. The histopathologic features and the expression of GATA3, cytokeratin (CK)7, mammaglobin staining and estrogen and progesterone receptors led to a diagnosis of breast cancer originating from the ectopic mammary tissue in the vulva. Given the rarity of these lesions, and the lack of standard treatment guidelines, the management of the patient was extrapolated from the established breast cancer treatment guidelines. Radiotherapy and chemotherapy followed by hormone therapy with aromatase inhibitor were administered to this patient in the metastatic setting with good palliation.
Adnexal torsion with normal ovary in the third trimester of a twin pregnancy: Case report and literature review
Authors: Ferrari Federico , Tisi Giancarlo , Forte Sara , Sartori Enrico , Odicino Franco 
Published: August 2018

AbstractManagement of adnexal torsion in a dichorionic diamniotic pregnancy at 32 weeks is presented. Adnexal torsion is a rare condition in pregnancy, particularly during late third trimester and with normal ovary and tube. The size of a twin uterus at late third trimester prevented a laparoscopic approach. A longitudinal laparotomic incision below the umbilicus permitted detorsion and fixation of the adnexa. To our knowledge, this is the first case reported in a late twin pregnancy.
Association between temporomandibular disorders and pubertal development: A systematic review
Authors: Song Yi Lin , Yap Adrian U. , Türp Jens C. 
Published: August 2018

SummaryThe aim of this systematic review (SR) was to determine the association between temporomandibular disorders (TMDs) and pubertal development. Due to the inadequacy of the conventional PICO (Population, Interventions, Comparisons and Outcome) format used for intervention‐based SRs, the Joanna Briggs Institute's guidelines for synthesising evidence related to associations with a focus on aetiology were adopted. A search of the PubMed and LIVIVO databases covering the period from January 1980 to May 2018 yielded four publications, which fulfilled the inclusion criteria. Analysis of articles based on the Pubertal Development Scale showed that TMD prevalence increases with pubertal development. Although no sex difference in TMD prevalence and diagnosis was observed, more females reported TMD anamnestic variables, including accounts of temporomandibular pain during pubertal maturity. The higher prevalence of depression and somatisation during pubertal development may contribute to more TMD symptom reporting in females. More prospective studies incorporating standardised methods for diagnosing TMDs and detecting comorbid psychosocial and somatic problems are desired to further elucidate the relationship between TMDs and pubertal development.
Pyrethroid and organophosphate pesticide resistance in field populations of horn fly in Brazil
Authors: Brito L. G. , Barbieri F. S. , Rocha R. B. , Santos A. P. L. , Silva R. R. , Ribeiro E. S. , Guerrero F. , Foil L. , Oliveira M. C. S. 
Published: August 2018

AbstractPesticides are used worldwide to control arthropod parasites in cattle herds. The indiscriminate and/or inappropriate use of pesticides without veterinary guidance is a reality in several countries of South America. Improper pesticide use increases the chances of contamination of food and the environment with chemical pesticides and their metabolites. Reduction of these contamination events is an increasing challenge for those involved in livestock production. The horn fly, Haematobia irritans (Linnaeus) (Diptera: Muscidae), is one of the most economically important parasites affecting cattle herds around the world. As such, horn fly control efforts are often required to promote the best productive performance of herds. Pesticide susceptibility bioassays revealed that pyrethroid resistance was widespread and reached high levels in horn fly populations in the Brazilian state of Rondônia. The knockdown resistance (kdr) sodium channel gene mutation was detected in all horn fly populations studied (n = 48), and the super kdr sodium channel gene mutation was found in all homozygous resistant kdr individuals (n = 204). Organophosphate resistance was not identified in any of the fly populations evaluated.
Intensive care nurse conceptions of well‐being: a prototype analysis
Authors: Jarden Rebecca J , Sandham Margaret , Siegert Richard J , Koziol‐McLain Jane 
Published: August 2018

ABSTRACTBackgroundAccurately conceptualizing intensive care nurse work well‐being is fundamental for successful engagement with workplace well‐being interventions. Little is currently known about intensive care nurse work well‐being.AimsThe study aimed to identify intensive care nurses' conceptions of work well‐being and ascertain whether the term ‘work well‐being’ is prototypically organized.MethodsThree linked studies conceptualize intensive care nurse well‐being. For study one, participants listed key features of work well‐being as free‐text responses. Study two measured whether there was prototypical organization of these responses. Study three sought to confirm the prototypical organization of the term ‘work well‐being’ through narrative ratings.ResultsA total of 82 New Zealand intensive care nurses were randomly allocated to the three studies; 65 participated. In study one (n = 23), the most frequently endorsed elements included: workload (n = 14), job satisfaction (n = 13) and support (n = 13). In study two (n = 25), the highest rated elements included: feeling valued, respect, support, work‐life balance and workplace culture. Elements of support, work‐life balance and workload were in the top five most frequently endorsed elements and were also rated in the top 12 most central. Overall, the ratings of centrality and number of endorsements were positively correlated (r = 0.35, P < 0.05). In study three (n = 17), nine participants selected the same rating across both narratives with no differentiation on the 11‐point scale and were excluded from analysis. The mean score for the central narrative was 7.88 and for the peripheral narrative was 7.38. Confirmatory analyses did not reach statistical significance.ConclusionsUnique conceptions of work well‐being were identified. Workload and work‐life balance were central characteristics. Feeling valued and experiencing respect and support were considered most important.Relevance to clinical practiceIntensive care nurse conceptions of work well‐being are fundamental for future measures of work well‐being and future interventional studies and initiatives.
Genomewide association analysis of salt tolerance in soybean [Glycine max (L.) Merr.]
Authors: Huang Lei , Zeng Ailan , Chen Pengyin , Wu Chengjun , Wang Dechun , Wen Zixiang 
Published: August 2018

AbstractSalinity is a common abiotic stress causing soybean [Glycine max (L.) Merr.] yield loss worldwide. The use of tolerant cultivars is an effective and economic approach to coping with this stress. Towards this, research is needed to identify salt‐tolerant germplasm and better understand the genetic and molecular basis of salt tolerance in soybean. The objectives of this study were to identify salt‐tolerant genotypes, to search for single‐nucleotide polymorphisms (SNPs) and QTLs associated with salt tolerance. A total of 192 diverse soybean lines and cultivars were screened for salt tolerance in the glasshouse based on visual leaf scorch scores after 15–18 days of 120 mM NaCl stress. These genotypes were further genotyped using the SoySNP50K iSelect BeadChip. Genomewide association mapping showed that 62 SNP markers representing six genomic regions on chromosomes (Chr.) 2, 3, 5, 6, 8 and 18, respectively, were significantly associated with salt tolerance (p < 0.001). A total of 52 SNP markers on Chr. 3 are mapped at or near the major salt tolerance QTL previously identified in S‐100 (Lee et al., 2014). Three SNPs on Chr. 18 map near the salt tolerance QTL previously identified in Nannong1138‐2 (Chen, Cui, Fu, Gai, & Yu, 2008). The other significant SNPs represent four putative minor QTLs for salt tolerance, newly identified in this study. The results above lay the foundation for fine mapping, cloning and molecular breeding for soybean salt tolerance.
Identification of quantitative trait loci for seed isoflavone concentration in soybean (Glycine max) against soybean cyst nematode stress
Authors: Carter Adam , Tenuta Albert , Rajcan Istvan , Welacky Tom , Woodrow Lorna , Eskandari Mehrzad 
Published: August 2018

AbstractIsoflavones are plant secondary metabolites produced in soybean (Glycine max), which provide plant defense against pathogens and are beneficial to human health. Soybean cyst nematode (SCN) is a major yield‐limiting pest in most soybean‐producing area across the world. Traits, seed isoflavones and SCN resistance are quantitative in nature, and their phenotypic evaluations are expensive. Quantitative trait loci (QTL) underlying the two traits will be helpful to develop SCN‐resistant lines with elevated isoflavones using marker‐assisted‐selection (MAS). This study aims to identify isoflavones and SCN‐related QTL in a soybean population consisting of 109 RILs, which was developed from a cross between two commercial soybean cultivars viz. ‘RCAT1004’ and ‘DH4202’ and grown in four non‐SCN and SCN‐infested fields during 2015 and 2016. While single marker ANOVA identified 10 QTL for isoflavones and five for SCN (p < 0.01), simple interval and multiple QTL mappings identified four QTL associated with isoflavones (LOD ≥ 2.2). These results contribute to a better understanding of the genetics of the two traits and provide molecular markers that can be used in MAS to facilitate developing SCN‐resistant soybeans with increased isoflavones.
When I hurt others, and when I get hurt: Integrating victim and perpetrator experiences of harm into a sense of moral agency
Authors: Pasupathi Monisha , Wainryb Cecilia 
Published: August 2018

AbstractIn a social world, occasionally we all will harm others, as well as be harmed. Previous research has focused largely on how perpetration and victimization events are distinct rather than on how they might be integrated with one another, jointly shaping moral agency. We report on an exploratory qualitative analysis of narratives about perpetration and victimization. Our sample included 30 participants divided evenly by gender and age (ages 11–12, 16–17, and 19–26). Our aims were: (a) to identify potential forms of integration in moral agency across perpetration and victimization; (b) to explore developmental paths in integration; and (c) to examine forms of integration that were not tied directly to the construction of moral agency. We found three frequent integration patterns: harm was similarly understandable in perpetrator and victim narratives; harm was similarly incomprehensible in perpetrator and victim narratives; and harm was understandable in perpetration narratives but incomprehensible in victim narratives. Other forms of integration suggestive of how diminished moral agency can be reclaimed via narrative also were identified.
A novel approach to developing organized multi‐speed evacuation plans
Authors: Li Xiang , Li Qiuping , Xu Xianrui , Xu Dong , Zhang Xihui 
Published: August 2018

AbstractCities are becoming more vulnerable to all kinds of hazards or events, especially with the unpredictable impacts of global climate change. All these trends provide an urgent need for the development of comprehensive and efficient contingency plans in urban spaces. Evacuation plans are important solutions to protect people from unforeseen effects of disasters. However, evacuees’ speed differences have been ignored or little considered among most of the existing research on developing organized evacuation plans. This article presents a novel approach to planning a multi‐speed evacuation. The objective is to minimize the whole network clearance time. Evacuees are grouped and each group is allocated a departure time and an evacuation route in order to minimize traffic conflicts. Three scheduling strategies and four priority rules are defined for determining the departure time of evacuation groups. Experiments based on a real‐world case have been conducted to validate the approach and compare the performance of these strategies and rules. The major conclusion is that, with the proposed approach, an evacuation plan can avoid traffic congestion and minimize the whole network clearance time, and the choice of scheduling strategies and priority rules should be based on practical evacuation objectives.
Effectiveness of the Mindfulness‐Based Stress Reduction Program on Blood Pressure: A Systematic Review of Literature
Authors: Solano López Ana L. 
Published: August 2018

AbstractBackgroundIn spite of the advances in hypertension prevention and treatment, there is a high percentage of people with elevated or uncontrolled blood pressure. New patient‐centered strategies are needed to support people managing their condition. A complementary behavioral treatment, the mindfulness‐based stress reduction (MBSR) program, needs to be evaluated for its potential to reduce blood pressure.AimsTo examine the literature on MBSR program effectiveness for blood pressure in adults with hypertension or elevated blood pressure.MethodsA systematic literature review of randomized control trials reporting the effectiveness of the MBSR program on systolic and diastolic blood pressure in people with hypertension or elevated blood pressure, published between 2012 and 2017 was conducted. Five databases were searched (PubMed, EMBASE, Web of Science, PsycINFO, and Cochrane Library). Data extraction and risk‐of‐bias assessment were performed.ResultsA total of five articles were included in the review. Most studies found a reduction in systolic and diastolic blood pressure between the intervention and control groups; however, this reduction was only observed in clinical blood pressure (in office settings) and not in ambulatory blood pressure (in out‐of‐office settings) measurements. Analysis within intervention groups suggests that MBSR program reduces clinical blood pressure measurements. Even though these reductions in blood pressure may be of clinical relevance, the findings should be interpreted with caution in view of the lack of studies and study limitations.Linking Evidence to ActionThe MBSR program is a promising behavioral complementary therapy to help people with hypertension lower their blood pressure through modifications in their lifestyle. More research is needed not only to identify the effectiveness of the MBSR program on blood pressure, but also to explore the mechanisms by which the program influences blood pressure.