bluuebunny/crossref_metadata_2025_split huggingface dataset:
Motivated to confront: How experiencing anger affects anchoring bias
Authors: Jung Heajung , Young Maia J 
Published: April 2019

AbstractPrior research has asserted that emotions affect anchoring bias in decision making through the emotion's certainty appraisal or through the emotion's action tendencies, but these prior studies investigate the role of each component—appraisal or action tendency—without accounting for potential effects of the other one. The current research investigates whether anger exerts a significant effect on anchoring bias by activating a desire to confront a potential anchor. Importantly, the studies compare the effect of anger versus disgust, emotions that differ in their action tendency but are similar in their certainty appraisal. In Study 1, participants completed an emotion induction task and then a negotiation task where the first offer from the negotiation partner served as a potential anchor. Anger led to more deviation from the anchor compared with disgust or neutral feelings. Subsequent studies provide evidence that the angry participants are less anchored when the anchor value comes from a more confrontable source (someone else vs. themselves in Study 2 and an out‐group member vs. an in‐group member in Study 3).
Fixed combination of oral NEPA (netupitant‐palonosetron) for the prevention of acute and delayed chemotherapy‐induced nausea and vomiting in patients receiving multiple cycles of chemotherapy: Efficacy data from 2 randomized, double‐blind phase III studies
Authors: Schwartzberg Lee , Karthaus Meinolf , Rossi Giorgia , Rizzi Giada , Borroni Maria E. , Rugo Hope S. , Jordan Karin , Hansen Vincent 
Published: April 2019

AbstractAimTo assess the efficacy of oral NEPA (netupitant‐palonosetron 300/0.50 mg) over multiple chemotherapy cycles.MethodsTwo randomized phase III studies evaluated a single dose of oral NEPA given on day 1 in chemotherapy‐naive patients receiving anthracycline‐cyclophosphamide (AC)–based (Study 1) or highly (HEC)/moderately (MEC) emetogenic chemotherapy (safety Study 2). Oral NEPA was compared with oral palonosetron 0.50 mg (Study 1) or oral aprepitant 125 mg day 1, 80 mg days 2‐3/palonosetron 0.50 mg (Study 2; no formal statistical comparisons). Oral dexamethasone was administered in all treatment groups. Complete response (CR; no emesis/no rescue medication), no emesis, and no significant nausea (NSN) rates during acute (0‐24 h) and delayed (>24‐120 h) phases of chemotherapy cycles 1‐4 in each study were evaluated.ResultsIn Study 1, 1450 patients received 5969 chemotherapy cycles; in Study 2, 412 patients received 1961 chemotherapy cycles. In each study, ≥75% of patients completed 4 or more cycles. In Study 1, oral NEPA was superior to palonosetron in preventing chemotherapy‐induced nausea and vomiting (CINV) in the acute and delayed phases of cycle 1, with higher rates of CR (all P < 0.05), no emesis (all P < 0.05), and NSN (delayed phase P < 0.05 cycles 1, 2, and 4) reported across 4 cycles. In Study 2, oral NEPA had numerically higher CR and NSN rates in the acute and delayed phases than aprepitant‐palonosetron in MEC/HEC patients.ConclusionOral NEPA was highly effective in preventing both acute and delayed CINV over multiple chemotherapy cycles of HEC, AC, and MEC regimens.Clinical trial registration numbersStudy 1, NCT01339260; Study 2, NCT01376297.
Exercise testing after chronic total coronary occlusion revascularization in patients with STEMI and a concurrent CTO: A subanalysis of the EXPLORE‐trial
Authors: van Veelen Anna , van Dongen Ivo M. , Elias Joëlle , Råmunddal Truls , Eriksen Erlend , van der Schaaf René J. , Claessen Bimmer E. P. M. , Postema Pieter G. , Henriques José P. S. 
Published: April 2019

AbstractObjectivesTo assess the effect of chronic total occlusion percutaneous coronary intervention (CTO PCI) on ventricular ectopy (VE) and symptomatology during exercise testing.BackgroundDuring exercise, the hypoxic myocardium in the CTO‐territory can act as a substrate for VE and could lead to anginal complaints.MethodsIn the EXPLORE‐trial, 302 ST‐segment elevation myocardial infarction (STEMI)‐patients were randomized to CTO PCI or no‐CTO PCI. For this sub‐study, we analyzed all available exercise electrocardiograms (X‐ECGs) at 4 months follow‐up on symptoms and electrocardiographic parameters.ResultsA total of 155 X‐ECGs were available, 80 in the CTO PCI group (51.6%) and 75 in the no‐CTO PCI group (48.4%). There were no differences regarding exercised time, achieved endurance, ST‐deviation nor maximum heart‐rate. The percentage of patients experiencing chest‐pain during exercise was lower in the CTO PCI group (0% vs. 8.5%, p = .03). Also, there was a trend towards a higher maximum systolic blood pressure (SBP, 185 mmHg vs. 175, p = .09). No difference in VE was found between randomization groups, but patients with successful CTO PCI had a higher frequency of VE, compared to failed and no‐CTO PCI (26% vs. 8%, p = .02). This did not result in higher frequencies of sustained ventricular arrhythmias or mortality.ConclusionIn conclusion, in STEMI‐patients, CTO PCI is associated with a small reduction of chest‐pain during exercise and tended to be associated with an increase of maximum SBP. The observation that successful CTO PCI was associated with more VE during exercise, compared with failed/no‐CTO PCI needs further exploration.
Perforated gastric carcinomatosis following invasive lobular cancer of the breast
Authors: De Gruttola Ivan , Adil Md Tanveer , D’Souza Lorraine , Jambulingam Periyathambi , Whitelaw Douglas 
Published: April 2019

Key Clinical MessageCurrent guidelines do not advocate a routine search for gastric metastasis in known patients of breast cancer. This makes it challenging to suspect them clinically as they progress over many years. Gastric carcinomatosis from primary invasive lobular cancer can perforate leading to life‐threatening abdominal emergency necessitating surgery.
A case report and focused literature review of d‐penicillamine and severe neutropenia: A serious toxicity from a seldom‐used drug
Authors: Pitman Stuart K. , Huynh Tony , Bjarnason Thorarinn A. , An Josiah , Malkhasyan Karen A. 
Published: April 2019

Key Clinical MessagePrescribing d‐penicillamine for Wilson's disease must be accompanied by vigilant monitoring, including a complete blood cell count with differential. For most, this should occur once or twice weekly during the first month of therapy and during periods of dose escalation, then every two weeks for six additional months, then monthly.
Catalytic Activation of Esterases by PEGylation for Polyester Synthesis
Authors: Noro Jennifer , Castro Tarsila G. , Gonçalves Filipa , Ribeiro Artur , Cavaco‐Paulo Artur , Silva Carla 
Published: April 2019

AbstractIn this work we explored PEGylation as an efficient strategy to improve esterase's catalytic performance. For this, we PEGylated three esterases, namely lipase from Candida antarctica B (CALB), lipase from Thermomyces lanuginosus (TL) and cutinase from Fusarium solani pisi (CUT) and evaluated their catalytic performance by using the biosynthesis of poly(ethylene glutarate) as model reaction. After PEGylation with a 5 kDa aldehyde‐PEG, CALB and cutinase revealed an increase of activity against p‐nitrophenyl butyrate hydrolysis (2‐fold of increase for CALB and 4‐fold of increase for cutinase). Unmodified and PEGylated lipase TL displayed however similar activity results. The polymerase activity of native and PEGylated esterases was also assessed. The data revealed a higher polymerase activity for the lipase TL and cutinase PEGylated forms (88 % conversion for PEG‐lipase TL and 34 % for PEG‐cutinase). Molecular dynamics were used to evaluate the effect of PEG on the geometry of the active site of enzymes with lid domain (TL and CALB). These studies corroborate the experimental data revealing a more open active site cavity for the PEGylated catalysts facilitating the catalysis.
Bridging the Green Gap: Metal–Organic Framework Heteromultilayers Assembled from Porphyrinic Linkers Identified by Using Computational Screening
Authors: Haldar Ritesh , Batra Kamal , Marschner Stefan Michael , Kuc Agnieszka B. , Zahn Stefan , Fischer Roland A. , Bräse Stefan , Heine Thomas , Wöll Christof 
Published: April 2019

AbstractIn organic photovoltaics, porphyrins (PPs) are among the most promising compounds owing to their large absorption cross‐section, wide spectral range, and stability. Nevertheless, a precise adjustment of absorption band positions to reach a full coverage of the so‐called green gap has not been achieved yet. We demonstrate that a tuning of the PP Q‐ and Soret bands can be carried out by using a computational approach for which substitution patterns are optimized in silico. The most promising candidate structures were then synthesized. The experimental UV/Vis data for the solvated compounds were in excellent agreement with the theoretical predictions. By attaching further functionalities, which allow the use of PP chromophores as linkers for the assembly of metal‐organic frameworks (MOFs), we were able to exploit packing effects resulting in pronounced redshifts, which allowed further optimization of the photophysical properties of PP assemblies. Finally, we use a layer‐by‐layer method to assemble the PP linkers into surface‐mounted MOFs (SURMOFs), thus obtaining high optical quality, homogeneous and crystalline multilayer films. Experimental results are in full accord with the calculations, demonstrating the huge potential of computational screening methods in tailoring MOF and SURMOF photophysical properties.
Corporate images and customer behavioral intentions in an environmentally certified context: Promoting environmental sustainability in the hospitality industry
Authors: Martínez Patricia , Herrero Ángel , Gómez‐López Raquel 
Published: April 2019

AbstractGrowing environmental awareness has made customers change their attitudes and increasingly demand that the hospitality industry provides products and services that are environmentally friendly. This sector faces increasing pressure to operate in a more ecofriendly manner given its negative influence on the natural environment. Extant research demonstrates that sustainable tourism can be promoted through environmental certifications. However, little attention has been paid to the relevance of customer perceptions about these schemes and their influence on customer behavioral intentions. So that, this study attempts to explore the conditions under which perceived green image leads to favorable customer behavioral intentions towards environmentally certified hotels by considering the mediating effects of functional and emotional images. A structured questionnaire was used to collect data from hotel customers in Spain. The results indicate that green image serves as a predictor of functional image, which in turn is linked to customer behavioral intentions. This shows that the evaluation of environmental issues influences the assessment of cognitive aspects, although not the direct evaluation of affective aspects. Consequently, green image associations directly influence the cognitive responses of consumers but not their emotions. Therefore, consumers will evaluate a hotel's functional image not only by considering traditional attributes but also by taking into account environmental issues. These findings suggest that hotel companies should work to develop a green positioning strategy developing products and services possessing both greenness and high‐value attributes.
Dynamic properties of strongly coupled dusty plasmas with particles of finite dimensions
Authors: Yerimbetova Lazzat T. , Davletov Askar E. , Arkhipov Yuriy V. , Tkachenko Igor M. 
Published: April 2019

AbstractThe aim of the present study is to determine the impact the finite size of dust particles has on the static and dynamic characteristics of the dust component of a plasma. Taking into account both the finite dimensions of dust grains and the plasma screening, a model expression is chosen for the interdust interaction potential. The static structure factor of dust particles is evaluated by iteratively solving the reference hypernetted‐chain approximation, which inherently contains the hard sphere model handled within the Percus–Yevick closure. The self‐consistent method of moments is then engaged to relate the static and dynamic structure factors by assuming that the second derivative of the dynamic structure factor with respect to the frequency vanishes at the origin. Thus, an analytical expression for the dynamic structure factor is validated over quite a broad domain of dusty plasma non‐ideality and grains packing fraction. The calculated spectrum of dust‐acoustic waves reveals the appearance of the roton minimum, which becomes less pronounced when the packing fraction of dust particles rises. It is also predicted that the wavenumber position of the roton minimum is de facto independent of the size of dust particles. New analytical expressions for the dust‐acoustic wave spectrum and decrement of damping are proposed and thoroughly checked.
Voltage balancing control based on gate signal delay in series connection of SiC‐MOSFET
Authors: Shingu Katsuya , Wada Keiji 
Published: April 2019

AbstractRecently, research and development of SiC power devices have been done, and SiC power devices have become commercially available. The SiC power devices are suitable for realizing to medium voltage applications. Since, the voltage rating of commercial power devices is limited to less than 1.2 kV, they should be connected in series to maintain a higher voltage rating. However parasitic parameters of these devices are not the same, and therefore the voltage sharing during turn‐off operations cannot be controlled. This article proposes a digital control for the voltage balancing of series connected SiC‐MOSFETs during turn‐off operations. In order to compensate the voltage unbalance conditions, this article presents a time‐adjustment gate‐drive circuit using a digital delay line; experimental results for the feedback control using a buck chopper circuit are also presented.
Associations between interoceptive sensitivity, intuitive eating, and body mass index in patients with anorexia nervosa and normal‐weight controls
Authors: Richard Anna , Meule Adrian , Georgii Claudio , Voderholzer Ulrich , Cuntz Ulrich , Wilhelm Frank H. , Blechert Jens 
Published: April 2019

AbstractReduced perception of bodily signals and low levels of intuitive eating have been reported in patients with anorexia nervosa (AN) compared with normal‐weight individuals. However, findings have been inconsistent and treatment progress might account for some of these inconsistencies. Thirty‐seven inpatients with AN and 39 normal‐weight controls completed a heartbeat perception task and the Intuitive Eating Scale–2. Patients with AN reported lower intuitive eating than controls, whereas interoceptive sensitivity did not differ between groups. Higher interoceptive sensitivity was related to higher intuitive eating across both groups. In patients with AN, both higher interoceptive sensitivity and intuitive eating correlated with the number of days in the hospital and with higher body mass index (BMI), when controlling for BMI at admission. These relationships suggest that interoceptive sensitivity and intuitive eating improve during treatment. Future research should determine whether these improvements promote weight gain or follow it.
Muffins enriched with dietary fiber from kimchi by‐product: Baking properties, physical–chemical properties, and consumer acceptance
Authors: Heo Yena , Kim Min‐Joo , Lee Jo‐Won , Moon BoKyung 
Published: April 2019

AbstractThis study aimed to evaluate the effects of dietary fiber from Chinese cabbage outer‐leaf powder, which is a main by‐product of kimchi, on the quality, texture properties, and sensory evaluation of muffins. The kimchi by‐product powder (KBP, 36.2% dietary fiber) was added at 1%–4% dietary fiber content, by replacing wheat flour (w/w basis). The physico‐chemical and sensory properties of the baked muffins were measured. The height and volume of the muffins decreased with the addition of KBP. Increasing the KBP content resulted in increased hardness and reduced chewiness. No significant difference was observed in the overall acceptance among the muffins, up to the 2% added dietary fiber group, and the positive effect of the incorporated KBP was also confirmed in the sensory evaluation. These results indicate that it is possible to produce functional muffins with increased dietary fiber content by adding KBP in place of flour.
Modification of barley dietary fiber through thermal treatments
Authors: Bader Ul Ain Huma , Saeed Farhan , Khan Muhammad Asif , Niaz Bushra , Rohi Madiha , Nasir Muhammad Adnan , Tufail Tabussam , Anbreen Friha , Anjum Faqir Muhammad 
Published: April 2019

AbstractThe current research was carried out to observe the effect of different thermal treatments on soluble and insoluble dietary fiber ratio to improve functional properties of barley. Two varieties of barley labeled as Haider‐93 and Jau‐87 were milled and then wet and dry heat‐treated. Soaking and then cooking of soaked and nonsoaked barley was performed. Untreated barley contained more insoluble dietary fiber (12.00–12.40 g/100g dm) than soluble dietary fiber (4.73–5.70 g/100g dm). Additionally, the modification of soluble (13.32%) and insoluble dietary fiber (8.79%) ratio through pressure cooking was nonsignificant while roasting showed significant results, that is, 53.91% increase in soluble dietary fiber and 8.79% decrease in insoluble dietary fiber. In phase II, cooking without soaking gave highest results, that is, 68.08% increase in soluble dietary fiber and 15.48% decrease in insoluble dietary fiber. Conclusively, among all treatments of phase I and II, the better results were shown by cooking without soaking.
Development of a Multiscale SOFC Model and Application to Axially‐Graded Electrode Design
Authors: Mastropasqua L. , Donazzi A. , Campanari S. 
Published: April 2019

AbstractA multiscale model is built to understand how microscale characteristics and the thermo‐chemical and electrochemical phenomena, occurring in the electrode and electrolyte assembly, may affect the overall performance of a solid oxide fuel cell (SOFC) stack. This study presents the integration of two‐dimensional finite volume models: a 1D microscale model and a 1D (or 2D) macroscale (channel/cell) model. The new tool is calibrated against the experimental data of a short‐stack via a numerical procedure aiming at the minimisation of the mean square deviation of the model from the measured data. Subsequently, the distribution of electrochemical active thickness in a state‐of‐the‐art solid oxide cell channel is calculated; the result is limited between 3% and 7% of the electrode thickness. An axially graded electrode is studied by changing the particle radii in order to locally control the triple phase boundary length distribution along the cell channel. The performances of a four‐section graded electrode is estimated in comparison to a reference non‐graded electrode. The average current density increases by approximately 6% in the short‐stack. If such a graded design was introduced into a state‐of‐the‐art cogeneration system, the extrapolation of these results suggests that a power output increase up to 13.5% is attainable.
The nonsense mutation MSH2 c.2152C>T shows a founder effect in Portuguese Lynch syndrome families
Authors: Pinheiro Manuela , Francisco Inês , Pinto Carla , Peixoto Ana , Veiga Isabel , Filipe Bruno , Santos Catarina , Maia Sofia , Silva João , Pinto Pedro , Santos Rui , Claro Isabel , Lage Pedro , Lopes Paula , Ferreira Sara , Rosa Isadora , Fonseca Ricardo , Rodrigues Paula , Henrique Rui , Chaves Paula , Pereira António Dias , Brandão Catarina , Albuquerque Cristina , Teixeira Manuel R. 
Published: April 2019

AbstractThe mutational spectrum of the MMR genes is highly heterogeneous, but specific mutations are observed at high frequencies in well‐defined populations or ethnic groups, due to founder effects. The MSH2 mutation c.2152C>T, p.(Gln718*), has occasionally been described in Lynch families worldwide, including in Portuguese Lynch syndrome families. During genetic testing for Lynch syndrome at the Portuguese Oncology Institutes of Porto and Lisbon, this mutation was identified in 28 seemingly unrelated families. In order to evaluate if this alteration is a founder mutation, haplotype analysis using microsatellite and SNP markers flanking the MSH2 gene was performed in the 28 probands and 87 family members. Additionally, the geographic origin of these families was evaluated and the age of the mutation estimated. Twelve different haplotypes were phased for 13 out of the 28 families and shared a conserved region of ∼3.6 Mb. Based on the mutation and recombination events observed in the microsatellite haplotypes and assuming a generation time of 25 years, the age estimate for the MSH2 mutation was 273 ± 64 years. The geographic origins of these families were mostly from the Northern region of Portugal. Concluding, these results suggest that the MSH2 c.2152C>T alteration is a founder mutation in Portugal with a relatively recent origin. Furthermore, its high proportion indicates that screening for this mutation as a first step, together with the previously reported Portuguese founder mutations, may be cost‐effective in genetic testing of Lynch syndrome suspects of Portuguese ancestry.
SSRI co‐medication with NOAC or VKA does not increase hospitalisation for bleeding: A retrospective nationwide cohort study in Austria 2010‐2015
Authors: Sheikh Rezaei Safoura , Mittlböck Martina , Reichardt Bertholdt , Wolzt Michael 
Published: April 2019

ObjectivesNon‐vitamin K oral anticoagulants (NOACs) or vitamin K antagonists (VKAs) are used for the prophylaxis and treatment of thromboembolic events. A potential drug–drug interaction and increased bleeding events have been reported with co‐medication of selective serotonin receptor inhibitors (SSRIs) and VKA. The aim of this study was to investigate the bleeding risk of a coprescription of NOAC or VKA with SSRI.MethodsPatients with prescription of NOAC or VKA and an antidepressant drug therapy (ADTx) were selected from the drug reimbursement database of 13 Austrian health insurance funds. For this cohort, hospital discharge diagnoses for gastrointestinal bleeding, cerebral haemorrhage, and bleeding anaemia between 2010 and 2015 were analysed.ResultsData were available from 50 196 female and 31 308 male patients. Among these, 892 patients had 987 hospitalisations with bleeding events. The most frequent bleeding cases were gastrointestinal bleedings with 588 events (59.6%), followed by cerebral haemorrhage with 344 (34.8%), and bleeding anaemia with 55 events (5.6%), respectively. The risk of bleeding events was similar between SSRI and other ADTx, when combined with oral anticoagulants (p = 0.51). Concomitant treatment of patients with SSRI or other ADTx and NOAC was associated with an increased bleeding risk compared with cotreatment with VKA (1.21, 95% CI: 1.05‐1.40; p = 0.0097).ConclusionCo‐medication of SSRI with VKA or NOAC has little if any impact on hospital discharge diagnoses for bleeding events compared with cotreatment of those anticoagulants with other antidepressant medications.