bluuebunny/crossref_metadata_2025_split huggingface dataset:
Inflammatory myofibroblastic lung tumor: its birth, its bleeding growth, its difficult diagnosis and its surgical end in a child
Authors: Pecoraro Luca , Clemente Maria , Tadiotto Elisa , Piacentini Giorgio , Pietrobelli Angelo , Degani Daniela 
Published: June 2018

Key Clinical MessageThe diagnosis of inflammatory myofibroblastic tumor is based on radiology and histology. The treatment is surgical, and the prognosis is good. For this reason, although this lung disease is rare, when a child show up at hospital with an unknown hemoptysis, this medical condition should not be underestimated.
Self‐Aggregation of a Naphthalene‐Monoimide Amphiphile and Its Charge‐Transfer‐Complex Driven Morphogenesis in Water
Authors: Ghosh Subhajit , Pramanik Bapan , Das Debapratim 
Published: June 2018

AbstractA detailed study on the self‐assembly of a naphthalene‐monoimide (NMI)‐containing amphiphile (A‐1) in aqueous medium is reported. The amphiphile forms micelles at a lower concentration and, with an increase in concentration, the micelles are transformed into vesicles. A detailed thermodynamic study reveals that the micelle‐to‐vesicle transformation is a spontaneous and entropy driven process. In the presence of an electron donor, 1,5‐dihydroxynaphthalene (DHN), the vesicles further transformed into tape‐like aggregates. A‐1 and DHN form a 1 : 1 charge‐transfer complex as shown from the ITC and absorption spectroscopic data. The charge‐transfer complexation was also found to be a thermodynamically favorable process. The tapes obtained from the charge‐transfer complexes were found to be more conductive that of the vesicles. Various spectroscopic, microscopic, ITC, XRD, and other techniques were utilized to reveal the underlying self‐assembly mechanism.
Pharmacokinetics, Safety, and Tolerability of the Novel Chymase Inhibitor BAY 1142524 in Healthy Male Volunteers
Authors: Kanefendt Friederike , Thuß Uwe , Becka Michael , Boxnick Stefanie , Berse Matthias , Schultz Armin , Otto Christiane 
Published: June 2018

AbstractThe orally available chymase inhibitor BAY 1142524 is currently being developed as a first‐in‐class treatment for left‐ventricular dysfunction after myocardial infarction. Results from 3 randomized, single‐center, phase 1 studies in healthy male volunteers examining the safety, tolerability, and pharmacokinetics of BAY 1142524 are summarized. In this first‐in‐human study, single oral doses of 1‐200 mg were administered in fasted state as liquid service formulation or immediate release (IR) tablets. The relative bioavailability and the effect of a high‐fat/high‐calorie meal were investigated at the 5‐mg dose. In a multiple‐dose escalation study, doses of 5‐50 mg twice daily and 100 mg once daily were given for 5 consecutive days. BAY 1142524 was safe and well tolerated and had no effects on heart rate or blood pressure compared with placebo. BAY 1142524 was absorbed with peak concentration 1‐3 hours after administration for IR tablets; it was eliminated from plasma with a terminal half‐life of 6.84‐12.0 hours after administration of liquid service formulation or IR tablets. Plasma exposures appeared to be dose‐linear, with a negligible food effect. There was only low accumulation of BAY 1142524 after multiple dosing. BAY 1142524 exhibited a pharmacokinetic profile allowing for once‐daily dosing. The absence of blood pressure effects after administration of BAY 1142524 supports the combination of this novel anti‐remodeling drug with existing standard of care in patients with left‐ventricular dysfunction after acute myocardial infarction.
Effect of Fe2O3 on steam gasification of subbituminous coal/woody biomass mixture
Authors: Shen Lingbo , Nakamura Ayano , Murakami Kenji 
Published: June 2018

AbstractThis study investigated the steam gasification of Indonesian Adaro coal and Japanese cedar mixed in a 1:1 ratio with the physical addition of 10 wt% Fe2O3 in 50 vol% H2O at ambient atmospheric pressure and 800°C for 1 h. The primary objective of this work was to examine the effectiveness of an iron catalyst on the interaction between Indonesian Adaro coal and Japanese cedar. The study demonstrated that the H2 evolution amount for co‐gasification of Japanese cedar and Adaro coal (with 1:1 ratio in weight) without a Fe catalyst was 100 mmol/g‐char. However, the H2 evolution amount for co‐gasification with the addition of Fe2O3 was 152 mmol/g‐char. The increase in the co‐gasification for H2 evolution was based on a change in the char structure during pyrolysis and gasification.
Visible light communication – An architectural perspective on the applications and data rate improvement strategies
Authors: Saadi Muhamamd , Ahmad Touqeer , Kamran Saleem M. , Wuttisittikulkij Lunchakorn 
Published: June 2018

AbstractDemand for bandwidth hungry applications and mobile services is pushing an unquenchable need for wireless capacity. Existing radio frequency networks are characterized by shared medium, inadequate spectrum, and restricted user capacity. Solid state lighting is modernizing indoor as well as outdoor illumination. The capability of quick switching of light emitting diode makes them superior to other lighting sources enabling simultaneous use as a communication and illumination device. Visible light communication (VLC) using light emitting diodes is an attractive approach for many networking scenarios and is considered as a complementary technology for future heterogeneous wireless networks.This article presents an architectural perspective on the applications and data rate improvement strategies. A wide range of VLC applications have been investigated, comparison has been drawn with radio frequency, and generalized network architecture is also proposed. Numerous applications of VLC are data rate intensive, so data rate improvement approaches have also been studied. At the end, a lucid conclusion is drawn about the applicability, acceptability, and utilization of VLC and co‐VLC–based systems.
‘No Evil is Without Good’: A Comparative Analysis of Pre‐pack Sales in the UK and the Netherlands
Authors: Kastrinou Alexandra , Vullings Stef 
Published: June 2018

AbstractIn the last decade or so, the pre‐pack has been widely endorsed as a significant rescue tool across a range of European jurisdictions. Although the seamless prepack can prove to be a very attractive method of affecting a corporate restructuring, a variety concerns nevertheless arise primarily due to the lack of transparency of the process. The aim of this article is to provide an overview of the pre‐pack process in two different jurisdictions commonly regarded as creditor‐friendly, namely, the UK and the Netherlands. In addition, the aim of the article is to offer a comparative analysis of the approach taken in these two jurisdictions towards the pre‐pack, with particular regard placed on the perspective of secured creditors. Copyright © 2018 INSOL International and John Wiley & Sons, Ltd.
Parallel Reorganizations under the Recast European Insolvency Regulation – Selected EU Law Issues
Authors: Richter Tomáš 
Published: June 2018

AbstractThe Recast European Insolvency Regulation (EIR) (Regulation 2015/848) repealed the rules in Articles 3(3) and 27 of the original EIR (Regulation 1346/2000) that required that secondary insolvency proceedings take the form of a liquidation (winding‐up). As a result, European debtors may now attempt to resolve their cross‐border insolvencies via parallel reorganization proceedings conducted both in the Member State of the debtor's centre of main interest and in one or more Member States in which the debtor possesses an establishment. This article aims to take account of the principal rules of the Recast EIR which, in addition to the national laws of the Member States involved, will regulate such attempts. Upon the review of these selected rules, the article concludes that, in principle, the Recast EIR provides EU debtors with a feasible cross‐border platform to reorganize in more than one Member State in parallel. However, the article finds that a particular rule central to the system of cross‐border insolvency under the EIR, namely, Article 45, which allows the multiple filing of claims in all proceedings conducted in respect of the debtor, has the potential to frustrate attempts at parallel reorganizations. This is particularly so where the cross‐filing rule combines with Member State law that is rigid as regards plan approval by creditor classes or minimum payouts to certain classes. Copyright © 2018 INSOL International and John Wiley & Sons, Ltd.
Luminescent Solar Concentrators Based on Aggregation Induced Emission
Authors: Pucci Andrea 
Published: June 2018

AbstractA promising path to cost‐effective photovoltaic (PV) systems is sunlight concentration. Over classical non‐imaging geometrical concentrators, luminescent solar concentrators (LSCs) possess several advantages: low cost and weight, elevated theoretical concentration factors and aptitude to efficiently working with diffuse light without tracking or cooling equipment. Although considerable progress has been made, current LSC‐PV systems attain low power conversion efficiencies due to critical processes that hinder their ability to deliver light to PV cells including fluorescence quenching due to dye aggregation. To overcome this issue, fluorophores with aggregation induced emission (AIEgens) have been proposed thanks to their high Stokes shift and quantum yield in the solid state. In this review, the current state of knowledge concerning the preparation of LSCs based on AIEgens is summarized with special reference on the strategy adopted aimed at increasing the absorption bandwidth while maximizing the solar collection.
Quality of life in celiac disease and the effect of gluten‐free diet
Authors: C Deepak , Berry Neha , Vaiphei Kim , Dhaka Narendra , Sinha Saroj K , Kochhar Rakesh 
Published: June 2018

Background and AimPatients with celiac disease (CD) have a poor health‐related quality of life (HR‐QOL). We assessed the QOL in patients with CD using both generic (SF‐12) and specific (CD‐QOL) questionnaires, and the effect of gluten‐free diet (GFD) on HR‐QOL.MethodsWe conducted a prospective follow‐up study based on consecutive patients of suspected CD between June 2014 and November 2015. After taking a detailed history, all patients were subjected to laboratory investigations (including complete blood count, biochemistry, and the IgA tTG antibody), followed by endoscopy and duodenal biopsies for histopathology. The HR‐QOL was assessed using SF‐12 and CD‐QOL questionnaires. Patients who were strictly adherent to GFD were re‐assessed at the end of 6 months for laboratory parameters and QOL.ResultsSixty adult patients of CD, with mean age of 28.85 ± 12.43 years, and a M:F ratio of 1.3:1, were enrolled in the study. The mean PCS (physical health composite scale score) and MCS (mental health composite scale score) at baseline were 37.20 ± 11.09 and 41.88 ± 8.39, which showed a statistically significant improvement after GFD to 50.30 ± 9.88 and 50.22 ± 9.04, respectively. Though there was no significant difference in the total CD‐QOL score after GFD, there was a significant improvement in the dysphoria and health‐concern subscales. We also found a negative correlation of the pre‐GFD symptom score (based on number of positive symptoms) with PCS and MCS and a positive correlation with the CD‐QOL score.ConclusionThis study has shown a reduced HR‐QOL in adult CD patients, which improves significantly on GFD, and is associated with a higher symptom number.
Design and methodology of a study on colorectal cancer in Johannesburg, South Africa
Authors: Bebington Brendan , Singh Elvira , Fabian June , Jan Kruger Christine , Prodehl Leanne , Surridge Daniel , Penny Clem , McNamara Lynne , Ruff Paul 
Published: June 2018

Background and AimCancer is one of the foremost causes of morbidity and mortality worldwide. Globally, colorectal cancer (CRC) is the third most diagnosed and fourth most important cause of cancer death. A total of 70% of all CRC‐related deaths occur in low‐ and middle‐income countries. In Sub‐Saharan Africa (SSA), estimating the burden of CRC is difficult. Only 27 of 43 SSA countries have formalized cancer registration systems; data quality is variable and national coverage rare.MethodsThis is a multidisciplinary, longitudinal cohort study started in January 2016. Patients >18 years with histologically confirmed primary adenocarcinoma of the colon and rectum, diagnosed within the previous 12 months, are eligible. Participants were assessed and were followed up for 3 years. Baseline information, including demographics, socioeconomic status, family history, medical and surgical non‐cancer‐related history, dietary history, colonoscopic findings, staging at presentation, treatment, and disease recurrence, is collected, as well as blood tests and histology results. Outcomes include disease recurrence (local and metastatic) and survival.Results and ConclusionThis study aims to describe the clinical presentation, management, and outcomes of adults with CRC in a multiethnic, urban South African population. It will be the first prospective study to describe clinical presentation, demographics, risk factors, treatment, and outcomes according to population group, from both private and state health‐care facilities in Johannesburg, South Africa. The results of this study will be relevant not only to South Africa but also to other SSA countries undergoing similar rates of rapid urbanization and epidemiological transition.
Osteoclast‐related markers in the hip joint fluid with subchondral insufficiency fracture of the femoral head
Authors: Kubo Yusuke , Motomura Goro , Ikemura Satoshi , Hatanaka Hiroyuki , Fukushi Jun‐ichi , Hamai Satoshi , Yamamoto Takuaki , Nakashima Yasuharu 
Published: June 2018

ABSTRACTSimilar to the radiological findings in rapidly destructive arthrosis of the hip joint (RDA), subchondral insufficiency fracture of the femoral head (SIF) can result in progressive femoral head collapse of unknown etiology. We thus examined the osteoclast activity of hip joint fluid in SIF with progressive collapse in comparison with that in RDA. Twenty‐nine hip joint fluid samples were obtained intraoperatively with whole femoral heads from 12 SIF patients and 17 RDA patients. SIF cases were classified into subgroups based on the presence of ≥2 mm collapse on preoperative radiographs: SIF with progressive collapse (n = 5) and SIF without progressive collapse (n = 7). The levels of tartrate‐resistant acid phosphatase (TRACP)‐5b, interleukin‐8, vascular endothelial growth factor (VEGF), and matrix metalloproteinase (MMP)‐9 were measured. The number of multinuclear giant cells at the subchondral region was histopathologically assessed using mid‐coronal slice of each femoral head specimen. The median levels of all markers and the median number of multinuclear giant cells in SIF with progressive collapse were significantly higher than those in SIF without progressive collapse, while there were no significant differences in SIF with progressive collapse versus RDA. Regression analysis showed that the number of multinuclear giant cells was positively correlated with the level of TRACP‐5b in joint fluid. The present study demonstrated the possible association of increased osteoclast activity with the existing condition of progressive collapse in SIF, which was quite similar to the findings in RDA, indicating that increased osteoclast activity may reflect the condition of progressive collapse in SIF as well as RDA. © 2018 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 36:2987–2995, 2018.
Analysis of salivary phenotypes of generalized aggressive and chronic periodontitis through nuclear magnetic resonance‐based metabolomics
Authors: Romano Federica , Meoni Gaia , Manavella Valeria , Baima Giacomo , Tenori Leonardo , Cacciatore Stefano , Aimetti Mario 
Published: June 2018

AbstractBackgroundRecent findings about the differential gene expression signature of periodontal lesions have raised the hypothesis of distinctive biological phenotypes expressed by generalized chronic periodontitis (GCP) and generalized aggressive periodontitis (GAgP) patients. Therefore, this cross‐sectional investigation was planned, primarily, to determine the ability of nuclear magnetic resonance (NMR) spectroscopic analysis of unstimulated whole saliva to discriminate GCP and GAgP disease‐specific metabolomic fingerprint and, secondarily, to assess potential metabolites discriminating periodontitis patients from periodontally healthy individuals (HI).MethodsNMR‐metabolomics spectra were acquired from salivary samples of patients with a clinical diagnosis of GCP (n = 33) or GAgP (n = 28) and from HI (n = 39). The clustering of HI, GCP, and GAgP patients was achieved by using a combination of the Principal Component Analysis and Canonical Correlation Analysis on the NMR profiles.ResultsThese analyses revealed a significant predictive accuracy discriminating HI from GCP, and discriminating HI from GAgP patients (both 81%). In contrast, the GAgP and GCP saliva samples seem to belong to the same metabolic space (60% predictive accuracy). Significantly lower levels (P < 0.05) of pyruvate, N‐acetyl groups and lactate and higher levels (P < 0.05) of proline, phenylalanine, and tyrosine were found in GCP and GAgP patients compared with HI.ConclusionsWithin the limitations of this study, CGP and GAgP metabolomic profiles were not unequivocally discriminated through a NMR‐based spectroscopic analysis of saliva.
A Comprehensive Comparison on Foam Behavior in the Presence of Light Oil and Heavy Oil
Authors: Pang Shishi , Pu Wanfen , Wang Chongyang 
Published: June 2018

AbstractCrude oil properties significantly affect foam behavior that is important to foam application in enhanced oil recovery. This study focused on the comparison on foam behavior in the presence of light oil and heavy oil. Foamability and foam stability, the bubble size, and the film thickness as well as the configuration of oil drops were fully investigated. Final results indicated that both the heavy oil and light oil increased the foamability of sodium dodecyl sulfate but decreased that of the amphoteric surfactant imidazoline. The positive effect of both light oil and heavy oil on foam stability was reconfirmed. However, heavy oil was more favorable to foam stability. The light oil may shorten the foam half‐life but prolong the foam drainage half‐life. The heavy oil was more effective in reducing the foam size and increasing the foam uniformity compared with light oil. According to the micrograph of foam, light oil was emulsified into quite small oil droplets, filling the plateau borders and lamellas. The heavy oil, in the form of far larger oil droplets, was mainly distributed in plateau borders only. The larger oil droplets resulted in the more stable foam, which was verified. Moreover, light oil (oil B) performed well in thickening the foam film, as did the heavy oil (oil A). But for the lightest oil (oil C), a thinning effect on the film was detected.
Phenolic and volatile compounds in Quercus humboldtii Bonpl. wood: effect of toasting with respect to oaks traditionally used in cooperage
Authors: Martínez‐Gil Ana , Cadahía Estrella , Fernández de Simón Brígida , Gutiérrez‐Gamboa Gastón , Nevares Ignacio , del Álamo‐Sanza María 
Published: June 2018

AbstractBACKGROUNDThe most frequent renewal of barrels of different origins and species is a current trend, but this demand does not match the current availability of wood. An alternative could be the use of Quercus humboldtii wood. However, there is little information about its composition. Because of this, the aim was to study low‐molecular‐weight phenols (LMWP), ellagitannins and volatile compounds in untoasted and toasted Q. humboldtii oak, and compare these with the species traditionally used in cooperage: Q. petraea (French and Romanian) and Q. alba (American).RESULTSThe LMWPs in Q. humboldtii were comparable to those in Q. petraea and Q. alba. Ellagitannin composition in Q. humboldtii was similar to that in Q. alba. The toasting process improved volatile composition, mainly in Q. humboldtii, presenting the highest concentration of several volatile compounds.CONCLUSIONThe results indicate that Q. humboldtii could be considered suitable for aging wine, although it is necessary to continue the study of this wood species to confirm its potential use in oenology. © 2018 Society of Chemical Industry
Cocoa bean husk: industrial source of antioxidant phenolic extract
Authors: Hernández‐Hernández Carolina , Morales‐Sillero Ana , Fernández‐Bolaños Juan , Bermúdez‐Oria Alejandra , Morales Alfonso Azpeitia , Rodríguez‐Gutiérrez Guillermo 
Published: June 2018

AbstractBACKGROUNDCocoa bean husk (CBH) is the principal by‐product of the cocoa industry and a significant agro‐industrial residue. In this study, using different hydrothermal treatments of CBH, it is shown that CBH is an important source of bioactive compounds, including theobromine, epicatechin and catechin.RESULTSTreatment over 150 °C significantly increased the yield of total and individual phenols and theobromine as well as the antioxidant capacity of the liquid fraction. A total of 52 different genotypes of CBH harvested in two seasons of production were analyzed. Overall, higher amounts of total phenols, theobromine and epigallocatechin were detected in samples from the 2015 season, while samples from 2014 had higher quantities of catechin and similar quantities of epicatechin.CONCLUSIONCBH treatment at 170 °C for 30 min produces an antioxidant‐rich extract high in phenols (55 mg g−1), sugars (220 mg g−1) and theobromine (56 mg g−1) that is suitable for applications in the food, cosmetic and nutraceutical industries. © 2018 Society of Chemical Industry
Electrochemotherapy pre‐treatment in primary squamous vulvar cancer. Our preliminary experience
Authors: Perrone Anna M. , Galuppi Andrea , Borghese Giulia , Corti Barbara , Ferioli Martina , Della Gatta Anna N. , Bovicelli Alessandro , Morganti Alessio G. , De Iaco Pierandrea 
Published: June 2018

Background and ObjectivesPrevious studies showed a local tumor control of 80% in patients with relapsed squamous cell vulvar cancer (V‐SCC) treated with electrochemotherapy. These results encouraged electrochemotherapy use as neo‐adjuvant treatment in V‐SCC. The objective of this study was to evaluate the effectiveness of electrochemotherapy in reducing tumor burden in V‐SCC.MethodsPatients with histological diagnosis of primary V‐SCC eligible for surgery were enrolled. Following accurate mapping of all the lesions, electrochemotherapy was performed. One month after electrochemotherapy clinical response was evaluated according to RECIST criteria and the type of surgery was confirmed or modified. Adjuvant therapies were prescribed depending on stage and pathological evaluation.ResultsWe report the results from nine patients treated with electrochemotherapy before surgery. The median age was 64 years (range 51‐81 years). Tumor response after electrochemotherapy was observed in seven patients (77.8%) with one CR and six PR, without complications. Tumor downsizing led to more conservative surgery in six patients (66.7%). At a median follow‐up of 8 months (range 2‐32 months) all patients were alive without disease.ConclusionsOur preliminary analysis suggests that ECT is a suitable treatment in patients with V‐SCC before surgery, reducing the tumor size and the surgical resection.