bluuebunny/crossref_metadata_2025_split huggingface dataset:
Interoperability of laboratory data in Switzerland – a spotlight on Bern
Authors: Dahlweid Fried-Michael , Kämpf Matthias , Leichtle Alexander 
Published: September 2018

Abstract
Laboratory data is a treasure chest for personalized medicine: it is – in general – electronically available, highly structured, quality controlled and indicative for many diseases. However, it is also a box with (probably more than) seven locks: laboratories use their own internal coding systems, results are reported in different languages (four official languages plus English with very distinct features in Switzerland), report formats are not uniform, standard nomenclature (e.g. Logical Observation Identifiers Names and Codes [LOINC]) is not routinely used and even these coding systems lack important information, including data, for example, about the specific “kit” used for testing or preanalytical procedures affecting the sample quality and result interpretability. Visualization of complex laboratory and reporting “-omics” data are additional challenges. Currently, there is no “passepartout” key for all these locks available, and also newer concepts such as Fast Health Interoperability Resources (FHIR) might not provide enough plasticity to unconditionally render laboratory data interoperable. In this short overview, we present current approaches in Switzerland with a specific focus on the exemplary Bernese implementations.
Properties of EPDM/PP thermoplastic vulcanizates produced by an intermeshing-type internal mixer comparing with a co-rotating twin-screw extruder
Authors: Teppinta Wattana , Junhasavasdikul Banja , Nithi-Uthai Nattapong 
Published: September 2018

Abstract
A unique technology for producing thermoplastic vulcanizate (TPV) has been developed using an intermeshing-type internal mixer (ITM). TPV produced by the ITM was compared with that produced using a co-rotating twin screw extruder (Co-TSE) to assess the former’s commercial possibilities. TPV, originating from ethylene-propylene-diene monomer (EPDM) and polypropylene (PP), was produced by both machines with equal filled volumes, same shear rate, and same specific mechanical energy. Results indicate that ITMs can be used to produce TPV with mechanical properties comparable to those of TPV produced by Co-TSE. TPV can be produced with a lower shear rate with ITM compared to Co-TSE. A long residence time can be maintained in the mixing chamber of the ITM, allowing high conversion of the cross-linking reaction and resulting in better elastic recovery properties due to the higher cross-linking density. However, this resulted in higher viscosity of TPV produced by ITM.
Conditional morphology in New York heritage Spanish: General and variable usage patterns
Authors: Viner Kevin Martillo 
Published: September 2018

AbstractThis paper analyzes the use of conditional morphology by second-generation Spanish speaking New Yorkers. We consider both overall usage patterns and variation, the latter exclusively in the apodosis of hypothetical utterances where three forms occur: the conditional, the subjunctive, and the indicative. The data are from semi-controlled sociolinguistic interviews with 26 Spanish-English second-generation bilingual participants from New York City. The participants stem from the six largest Spanish-speaking national origins in the city: Puerto Rican, Dominican, Cuban, Mexican, Colombian, and Ecuadorian. The findings show that conditional morphology is active in the grammars of these bilinguals, but variation does manifest between the three aforementioned forms in the apodosis. Furthermore, three of the 10 external variables identified for the investigation are found to be statistically significant in the cohort: level of English skill, level of education, and areal origin.
Creative Grammarians: Cognition, Language and Literature – An Exploratory Response
Authors: Schneck Peter 
Published: September 2018

Abstract
Any definition of creativity is a ‘machine’ which produces exactly those instances of creativity that follow the rules of the respective definition – so how does one escape the conundrum of defining individual creativity without turning it into a mere act of reproduction? One of the central tenets of the present volume is that Construction Grammar is particularly suited to bridge the gap between everyday linguistic creativity and highly professionalized and conventionalized forms of cultural reproduction, especially creative literature. While it appears to merely follow a trend in cognitive linguistics, which emerged and firmly established itself over the last three decades, and which emphasizes the creative potential of linguistic practices over and against the definition of language and speech as a rule-based system of engendering constraints, Construction Grammar insists on its ability to provide a most profitable interdisciplinary approach for the study of creativity and language – one that would also be able to embrace and empower the study of literary creativity.
Farklı anız yönetim sistemlerinin yakıt, kapasite yönünden karşılaştırılması ve doğrudan anıza ekim
Authors: KOLAY Betül , GÜRSOY Songül , AVŞAR Özlem , SESSİZ Abdullah 
Published: September 2018

Güneydoğu Anadolu Bölgesinde buğday
hasadından sonra tarlada kalan anız çiftçiler tarafından genellikle
yakılmaktadır. Bu çalışmada ülkemizde ve bölgemizde anız yakmanın neden olduğu
problemlerin azaltılması ve üreticilere uygun bir buğday hasat yönteminin
tavsiye edilebilmesi amaçlanmıştır. 2012 yılında yürütülen bu çalışma iki farklı
anız biçme yüksekliği ve beş farklı anız yönetim sisteminde
gerçekleştirilmiştir. Çalışmada yöntemlerin yakıt tüketimi, iş başarısı, tarla
yüzeyinde kalan anız miktarı incelenmiştir. Ayrıca uygulanan bu yöntemlerden
sonra hasat edilen alanlara mibzerle doğrudan anıza mercimek ekimi yapılmıştır.
Yöntemlerin mercimek bitkisinin tarla filiz çıkışına (TFÇ) olan etkisi incelenmiştir.
Sonuç olarak biçerdövere monte edilmiş sap parçalayıcı ile saman yapılarak
samanın biçerdöver tarafından çekilen tarım arabası ile tarladan
uzaklaştırıldığı uygulamada yakıt tüketimi en yüksek (29.41 L ha-1),
buğdayın biçerdöverle hasat edilip anızın tarlada bırakıldığı uygulamada iş
başarısı (1.85 ha h-1) ve tarladaki anız miktarı
(3716.43 kg ha-1) en yüksek bulunmuştur. En yüksek tarla
filiz çıkışı oranı da biçerdövere monte edilmiş sap parçalayıcı ile saman
yapılarak samanın biçerdöver tarafından çekilen tarım arabası ile tarladan
uzaklaştırıldığı uygulama (213.77 adet m-2) ile
biçerdövere monte edilmiş sap parçalayıcı ile saman yapılarak samanın tarla
yüzeyine dağıtıldığı (203.99 adet m-2) uygulamalarda elde
edilmiştir.
Special Issue on Active and Passive Vibration Damping in Machine Tools
Authors: Zaeh Michael F. 
Published: September 2018

Automation of machine tools has made them more productive, thereby providing an advantage for sustainability and the welfare of mankind. However, in many cases, the successful automation of machine tools requires the avoidance of self-excited chatter vibrations, resulting in a reliable stable state for cutting. Machine tool operators tend to use the machines close to their power thresholds, thereby unknowingly driving them toward the limits of their stability. Much progress has been made in the last few decades concerning the understanding and prediction of such vibrations, and this has led to improvements such as higher cutting rates and chip thicknesses.
Several countermeasures such as active and passive damping are available for avoiding chatter vibrations in machine tools. However, their industrial use is not common yet. In fact, the industry is somewhat unfamiliar with many of these countermeasures. The hesitant attitude of the machine tool builders to apply such countermeasures is a result of several factors: active and passive damping devices are additional system components that require design, tuning, and maintenance. Furthermore, they are associated with a risk of failure, resulting in additional down times of the machines. Additionally, if a machine requires such devices to achieve the desired specifications, the customer’s opinion regarding it can be negatively affected. This situation is challenging for machine tool builders, users, and academia as well. Therefore, we decided to dedicate a special issue of IJAT to this topic.
This special issue focuses on both active and passive damping measures, particularly the measures that are systematically designed and deliberately implemented to increase the chatter-free depth of cut in machine tools. The papers in this issue identify successful applications or at least a vision for them. Additionally, models demonstrating the effects of the chosen active or passive damping systems are presented. Some of these models can also be used to systematically select the parameters of the system. Some of the systems can be easily applied as low-cost patch-up solutions to improve the behaviors of the machines already in use.
I hope that this special issue delivers a valuable overview of the existing approaches to introduce additional damping in machine tools. I would like to sincerely thank all the authors for their dedication and the well written and illustrated manuscripts. I would also like to thank the reviewers for their efforts to ensure the quality of this issue. Finally, I am very thankful to IJAT for their immense cooperation and support. I wish you all the best and hope that you can benefit from the content of this special issue.
Special Issue on Progress of Manufacturing Technology
Authors: Yamada Keiji , Ohashi Kazuhito , Ishida Tohru , Sugino Tadanori 
Published: September 2018

First, we would like to express our sincere condolences to the victims of the landslides and floods caused by the torrential rain in Japan in July 2018. We were terribly grieved to hear about these disasters during the editing of this special issue of the International Journal of Automation Technology (IJAT), and we sincerely hope for the revival of the disaster-stricken areas.
This special issue focuses on the progress in manufacturing technologies for maximizing product quality and reducing costs, especially in the mechanical industry. Manufacturing technologies have been developing in order to meet the changes in social and economic environments such as progress in informatization, diverse needs, and increasing demands for a sustainable society. At present, engineers and researchers in the field of manufacturing are facing an unprecedented rapid change caused by the fourth industrial revolution. Therefore, research in this field is also expected to develop more than ever before.
This special issue of IJAT contains seven research papers on topics including shearing of metal sheets, machine tools and machining technology, precision dimensional measurement, and nanoimprinting process. Some of the papers, revised and extended at the editors’ request, were presented originally at the 9th International Conference on Leading Edge Manufacturing in 21st Century (LEM21), held in Hiroshima, Japan in 2017.
The editors thank the authors and reviewers for their comprehensive efforts in making this special issue possible, and hope that these articles will encourage further research on manufacturing technologies.
REQUIREMENTS FOR EFFICIENT PCR CLAMPING BY LOCKED NUCLEIC ACID OLIGONUCLEOTIES FOR SIMPLE AND SENSITIVE DETECTION OF SOMATIC MUTATIONS
Authors: Shamanin V. A. , Karpov I. V. , Pisareva E. E. , Gutkina N. I. , Kovalenko S. P. 
Published: September 2018

PCR clamping/wild-type blocking PCR with non-extendable locked nucleic acid (LNA) oligonucleotides is used for sensitive detection of somatic mutations in tumors. Various versions of the technique use different DNA polymerases and LNA oligonucleotides with and without additional phosphorothioate modifications. Here we studied requirements for successful PCR clamping with LNA oligonucleotides and Taq DNA polymerase for analysis of mutations in KRAS and BRAF genes by means of real-time PCR and Sanger sequencing. We found that addition of phosphorothioate linkages at the 5’-end of LNA oligonucleotide to protect from 5’- exonuclease activity of Taq DNA polymerase did not improve clamping. For most target sequences, efficient clamping was observed at melting temperature of LNA oligonucleotide 20‑25°C above annealing/extension temperature of the PCR with a 2-step protocol. Under such conditions, simple and sensitive detection of mutations in KRAS and BRAF genes was feasible using real-time PCR with TaqMan probes or Sanger sequencing.
COMPARATIVE ANALYSIS OF THE EXOSOMAL CARGO OF THE ESTROGEN-RESISTANT BREAST CANCER CELLS
Authors: Semina S. E. , Barlev N. A. , Mittenberg A. G. , Krasilnikov M. A. 
Published: September 2018

The exosomes involvement in the pathogenesis of tumors is based on their property to incorporate into the recipient cells resulting in the both genomic and epigenomic changes. Earlier we have shown that exosomes from different types of estrogen-independent breast cancer cells (MCF-7/T developed by long-term tamoxifen treatment, and MCF-7/M) developed by metformin treatment were able to transfer resistance to the parent MCF-7 cells. To elucidate the common features of the both types of resistant exosomes, the proteome and microRNA cargo of the control and both types of the resistant exosomes were analyzed. Totally, more than 400 proteins were identified in the exosome samples. Of these proteins, only two proteins, DMBT1 (Deleted in Malignant Brain Tumors 1) and THBS1 (Thrombospondin-1), were commonly expressed in the both resistant exosomes (less than 5% from total DEPs) demonstrating the unique protein composition of each type of the resistant exosomes. The comparative analysis of the miRNA differentially expressed in the both MCF-7/T and MCF-7/M resistant exosomes revealed 180 up-regulated and 202 down-regulated miRNAs. Among them, 4 up-regulated and 8 down-regulated miRNAs were associated with progression of hormonal resistance of breast tumors. The bioinformatical analysis of 4 up-regulated exosomal miRNAs revealed 2 miRNAs, mir- 101and mir-181b, which up-regulated PI3K signaling supporting the key role of PI3K/Akt in the development of the resistant phenotype of breast cancer cells.
Effect of Paclitaxel-Loaded PLGA Nanoparticles on MDA-MB Type Cell Lines: Apoptosis and Cytotoxicity Studies
Authors: Vijayan Venugopal , Shalini Krishnan , Yugesvaran V. , Yee Teh Hui , Balakrishnan Siventhiran , Palanimuthu Vasanth Raj 
Published: September 2018

Background:
Triple-Negative Breast Cancer is an aggressive type of breast cancer, which is not treatable
by chemotherapy drugs, due to the lack of Estrogen Receptor (ER), Progesterone Receptor (PR) expression
and Human Epidermal Growth Factor Receptor 2 (HER2) on the cell surface.

Objective:
The aim of this study was to compare the effect of paclitaxel loaded PLGA nanoparticle (PTX-NPs) on
the cytotoxicity and apoptosis of the different MDA-MB type of cell lines.

Method:
PTX-NPs were prepared by nanoprecipitation method and characterized earlier. The cytotoxicity of
PTX-NPs was evaluated by MTT and LDH assay, later apoptosis was calculated by flow cytometry analysis.

Results:
The prepared NP size of 317.5 nm and zetapontial of -12.7 mV showed drug release of 89.1 % at 48 h.
MDA-MB-231 type cell showed significant cytotoxicity by MTT method of 47.4 ± 1.2 % at 24 h, 34.6 ± 0.8 % at
48 h and 23.5 ± 0.5 % at 72 h and LDH method of 35.9 ± 1.5 % at 24 h, 25.4 ± 0.6 % at 48 h and 19.8 ± 2.2 % at
72 h with apoptosis of 47.3 ± 0.4 %.

Conclusion:
We have found that PTX-NPs showed the cytotoxic effect on all the MDA-MB cancer cell lines and
showed potent anticancer activities against MDA-MB-231 cell line via induction of apoptosis.
Design, Synthesis, In vitro Cytotoxic Activity Evaluation, and Study of Apoptosis Inducing Effect of New Styrylimidazo[1,2-a]Pyridines as Potent Anti-Breast Cancer Agents
Authors: Khalili Faeze , Akrami Sara , Safavi Malihe , Mohammadi-Khanaposhtani Maryam , Saeedi Mina , Ardestani Sussan K. , Larijani Bagher , Zonouzi Afsaneh , Tehrani Maliheh B. , Mahdavi Mohammad 
Published: September 2018

Background:
This paper reports synthesis, cytotoxic activity, and apoptosis inducing effect of a novel
series of styrylimidazo[1,2-a]pyridine derivatives.

Objective:
In this study, anti-cancer activity of novel styrylimidazo[1,2-a]pyridines was evaluated.

Methods:
Styrylimidazo[1,2-a]pyridine derivatives 4a-o were synthesized through a one-pot three-component reaction
of 2-aminopyridines, cinnamaldehydes, and isocyanides in high yield. All synthesized compounds 4a-o were
evaluated against breast cancer cell lines including MDA-MB-231, MCF-7, and T-47D using MTT assay. Apoptosis
was evaluated by acridine orange/ethidium bromide staining, cell cycle analysis, and TUNEL assay as the mechanism
of cell death.

Results:
Most of the synthesized compounds exhibited more potent cytotoxicity than standard drug, etoposide.
Induction of apoptosis by the most cytotoxic compounds 4f, 4g, 4j, 4n, and 4m was confirmed through mentioned
methods.

Conclusion:
In conclusion, these results confirmed the potency of styrylimidazo[1,2-a]pyridines for further drug
discovery developments in the field of anti-cancer agents.
Mild Cognitive Impairment and its Diagnosis to Progression to Dementia with Several Screening Measures
Authors: Sinha Avanika , Sinha Ambalika 
Published: September 2018

Background:Mild Cognitive Impairment (MCI) is the stage of an individual’s life in which there can be traced a slight amount of decline in cognitive functioning that comprised of memory and thinking skills. This decay in cognitive functioning does not affect the daily functioning of a patient’s life as it happens in the case of dementia.Objective:To review various forms of screening test measures to assess mild cognitive impairment and its extension towards the gradual onset towards the severe cognitive dysfunctioning such as dementia.Method:There are certain functional impairments that are identical to each other. As far as memory and thinking abilities are concerned, its range may vary from minimal to mild that remains quite unnoticed by the person.Results:Presently, the impact of medication is not so effective for MCI. Regular practices of exercises, mind activity and social involvement may help in decreasing risk of further cognitive function decline. Patients with MCI may carry greater risks of developing dementia as compared to the general population. The present paper discusses various intervention techniques and screening measures to mitigate the prevalence of MCI and to reduce progression of dementia.Conclusion:Prevalence of Mild Cognitive Impairment could be reduced with the primary administration of intervention strategies and technology in order to reduce its progression to dementia. The classification and categorization of MCI in getting broader and clear day by day. The expansion in the use of imaging techniques and other neurological intervention strategies may further enhance the detection of subjects with MCI.
REFORMA PSIQUIÁTRICA VERSUS SISTEMA DE JUSTIÇA CRIMINAL: A LUTA PELA EFETIVIDADE DOS DIREITOS HUMANOS AO LOUCO INFRATOR
Authors: De Deus Pereira Sarah Caroline 
Published: September 2018

Cuida-se de analisar as implicações da Lei n. 10.216/01, alcunhada por Lei da Reforma Psiquiátrica, no que se refere ao tratamento despendido ao louco infrator. Por conseguinte, evidenciar a problemática da aplicabilidade da política de saúde mental face ao pranteado modelo jurídico-terapêutico-punitivo-prisional dos Hospitais de Custódia e Tratamento Penitenciários (HCTPs). Neste raciocínio, se mostra evidente o conflito aos direitos humanos em face ao diploma legal em comento, por não se coadunarem com o sistema de justiça criminal brasileiro, sendo este ineficaz no tratamento do portador de transtorno mental que comete crime, em especial nos casos de psicopatia.Palavras-chave: Lei da Reforma Psiquiátrica; louco infrator; direitos humanos; justiça criminal; Direito Penal.AbstractTake care to analyze the implications of the Law 10.216/01, nicknamed by the Psychiatric Reform Law, as when handling the insane offender spent. By therefore highlight the issue of applicability of mental health policy in the face of model mourned Therapeutic legal punishment of prison-hospitals Custody and Correctional Treatment (HCTPs). In this reasoning, the conflict appears evident rights human face to the statute in comment, for not commensurate with the Brazilian criminal justice system, which is ineffective in the treatment of patients with mental disorder who commits a crime, especially in cases of psychopathy.Keywords: Psychiatric Reform Act; insane offenders, human rights, criminal justice, criminal law.
ONLINE MEDIA AS CONFLICT GENERATORS
Authors: Stamenković Ivana , Nikolić Miljana , Aleksić Dušan 
Published: September 2018

The media have always had great influence on the construction of attitudes and opinions of the public, thus it comes as no surprise that they constantly adjust to contemporary tides and the ways in which the public obtains information. Thanks to the popularity and possibilities offered by the Internet, the media were forced to converge towards online forms of reporting. Besides this, the Internet enabled the removal of state limits when it comes to informing, so the public can learn more easily about events from all over the world. In this way, mass-media communication gets new outlines while directing social tides on the global level. Although such a trend can be useful, it can also carry certain dangers. Therefore, the new media can become a platform for international conflicts and lead to possible interruption of good relations among states. Considering the fact that relations between Serbia and Croatia are characterised by a now concluded war, this paper examines the way in which the Serbian and the Croatian online media report on the relationship between the two states from the perspective of political relations, media presentations of each other, as well as how large the role of the modern media is in provoking new conflicts. Using a quantitative-qualitative analysis of the content, both the Serbian and the Croatian versions of the portal “24 hours” were analysed within the period from April 1 to April 30, 2017.
Los 68: movimientos estudiantiles y sociales en un emergente transnacionalismo y sus olas dentro del sistema-mundo. A manera de editorial
Authors: Bokser Misses-Liwerant Judit , Saracho López Con Federico José 
Published: September 2018

<p>El presente artículo estudia los movimientos de 1968 alrededor del mundo como muestra de incipientes procesos de globalización y un nuevo transnacionalismo en cuyos márgenes cambiantes los nuevos actores concatenaron agencia social y circuitos culturales para trascender las fronteras nacionales. A través del análisis de algunos de los casos más representativos, se estudia el hilvanado transnacional que se dio en 1968, a partir de la movilización estudiantil y los movimientos sociales que cuestionaron los regímenes políticos de diverso signo, así como su escasa capacidad de respuesta –cuando no represión– a las demandas por derechos civiles, por reformas democráticas y por el fin de la guerra. El examen de las convergencias y divergencias a nivel global, así como sus contradicciones no desatiende el análisis de los casos específicos. Junto al encuadre analítico, el artículo refiere, a su vez, a manera de editorial, a las colaboraciones que conforman este número especial de la Revista. El texto abre así un rico debate sobre 1968 como año fundacional.</p><p> </p>